bluuebunny/crossref_metadata_2025 huggingface dataset:
High School Football and Risk for Depression and Suicidality in Adulthood: Findings From a National Longitudinal Study
Authors: Iverson Grant L. , Terry Douglas P.
Published: February 2022

Background

There is growing public concern regarding the potential long-term effects of playing football on brain health, specifically that playing football before and during high school might cause damage to the brain that manifests years or decades later as depression or suicidality. This study examined if playing high school football was associated with increased lifetime risk for depression, suicidality over the past year, or depressed mood in the past week in men aged between their middle 30 s to early 40 s.

Methods

Publicly available data from the National Longitudinal Study of Adolescent to Adult Health were analyzed. This longitudinal, prospective cohort study sampled nationally representative U.S. youth starting in 1994–1995 (Wave I) and most recently in 2016–2018 (Wave V). A total of 3,147 boys participated in Wave I (median age = 15), of whom 1,805 were re-assessed during Wave V (median age = 38).

Results

Of the 1,762 men included in the study, 307 (17.4%) men reported being diagnosed with depression and 275 (15.6%) reported being diagnosed with an anxiety disorder or panic disorder at some point in their life. When comparing men who played high school football to those who did not, there were no differences in the proportions of the sample who had a lifetime diagnosis of depression, lifetime diagnosis of anxiety/panic disorders, suicidal ideation in the past year, psychological counseling in the past year, or current depressed mood. However, men who received psychological counseling and/or experienced suicidal ideation during adolescence were significantly more likely to report a lifetime history of depression, suicidal ideation in the past year, and current depressed mood.

Conclusion

Individuals who reported playing football during adolescence did not have an increased risk of depression or suicidal ideation when they were in their middle 30 s to early 40 s, but mental health problems during adolescence were associated with an increased risk for psychological health difficulties more than 20 years later.
Neural Correlates Predicting Lane-Keeping and Hazard Detection: An fMRI Study Featuring a Pedestrian-Rich Simulator Environment
Authors: Oba Kentaro , Hamada Koji , Tanabe-Ishibashi Azumi , Murase Fumihiko , Hirose Masaaki , Kawashima Ryuta , Sugiura Motoaki
Published: February 2022

Distracted attention is considered responsible for most car accidents, and many functional magnetic resonance imaging (fMRI) researchers have addressed its neural correlates using a car-driving simulator. Previous studies, however, have not directly addressed safe driving performance and did not place pedestrians in the simulator environment. In this fMRI study, we simulated a pedestrian-rich environment to explore the neural correlates of three types of safe driving performance: accurate lane-keeping during driving (driving accuracy), the braking response to a preceding car, and the braking response to a crossing pedestrian. Activation of the bilateral frontoparietal control network predicted high driving accuracy. On the other hand, activation of the left posterior and right anterior superior temporal sulci preceding a sudden pedestrian crossing predicted a slow braking response. The results suggest the involvement of different cognitive processes in different components of driving safety: the facilitatory effect of maintained attention on driving accuracy and the distracting effect of social–cognitive processes on the braking response to pedestrians.
Level of Orthographic Knowledge Helps to Reveal Automatic Predictions in Visual Word Processing
Authors: Huang Zehao , Yang Shimeng , Xue Licheng , Yang Hang , Lv Yating , Zhao Jing
Published: February 2022

The brain generates predictions about visual word forms to support efficient reading. The “interactive account” suggests that the predictions in visual word processing can be strategic or automatic (non-strategic). Strategic predictions are frequently demonstrated in studies that manipulated task demands, however, few studies have investigated automatic predictions. Orthographic knowledge varies greatly among individuals and it offers a unique opportunity in revealing automatic predictions. The present study grouped the participants by level of orthographic knowledge and recorded EEGs in a non-linguistic color matching task. The visual word-selective N170 response was much stronger to pseudo than to real characters in participants with low orthographic knowledge, but not in those with high orthographic knowledge. Previous work on predictive coding has demonstrated that N170 is a good index for prediction errors, i.e., the mismatches between predictions and visual inputs. The present findings provide unambiguous evidence that automatic predictions modulate the early stage of visual word processing.
Fermentation and Storage Characteristics of “Fuji” Apple Juice Using Lactobacillus acidophilus, Lactobacillus casei and Lactobacillus plantarum: Microbial Growth, Metabolism of Bioactives and in vitro Bioactivities
Authors: Yang Jie , Sun Yue , Gao Tengqi , Wu Yue , Sun Hao , Zhu Qingzheng , Liu Chunsheng , Zhou Chuang , Han Yongbin , Tao Yang
Published: February 2022

Fruit juices have been widely used as the substrates for probiotic delivery in non-dairy products. In this study, three lactic acid bacteria (LAB) strains, including Lactobacillus acidophilus, Lactobacillus casei and Lactobacillus plantarum, were selected to ferment apple juice. During 72-h of fermentation, these LAB strains grew well in the apple juice with significant increases in viable cell counts (from 7.5 log CFU/mL to 8.3 log CFU/mL) and lactic acid content (from 0 to 4.2 g/L), and a reduction of pH value (from 5.5 to around 3.8). In addition, the antioxidant and antibacterial capacities of fermented apple juice in vitro were significantly improved through the phenolic and organic acid metabolisms. After storage at 4°C for 30 days, the total amino acid content of fermented apple juice was significantly increased, although the viable cell counts and total phenolic content were decreased (p < 0.05). Furthermore, the stored fermented apple juices still possessed antibacterial and in vitro antioxidant activities. Overall, all the selected LAB strains could be suitable for apple juice fermentation and can effectively improve their biological activities.
Predictive Efficacy of Blood-Based Tumor Mutation Burden Assay for Immune Checkpoint Inhibitors Therapy in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis
Authors: Zhang Nan , Zhang Jinwei , Wang Guoqing , He Xin , Mi Yin , Cao Ying , Yu Xiaoxu
Published: February 2022

Background

In non-small cell lung cancer (NSCLC) patients treated by immune checkpoint inhibitors (ICIs), tumor mutation burden (TMB) has been found to have predictive potential for survival. When compared to TMB detection in tissue (tTMB), detecting TMB in the blood (bTMB) has practical advantages; yet, the results of various studies are conflicting. The question of whether bTMB can be utilized as a predictive biomarker is becoming increasingly contentious. To confirm the predictive efficacy of bTMB, researchers did a systematic review and meta-analysis to look into the relationship between ICIs and bTMB.

Method

From the inception to March 2021, Cochrane Library, PubMed, EMBASE and other databases were systematically searched. The predictive value of bTMB in ICIs, or the efficacy of ICIs against chemotherapy, was studied. The results were presented as pooled ratio rate (RR) and hazard ratio (HR) with 95% confidence intervals for the Objective response rate (ORR), progression-free survival (PFS), and overall survival (OS). Subgroup analysis, heterogeneity analyses, and sensitivity analysis were also performed.

Results

A total of 2,610 NSCLC patients were studied in seven trials. There were no significant differences in OS (HR = 1.09; 95% CI: 0.62–1.91, P = 0.774) or PFS (HR = 0.73; 95% CI: 0.20–2.65, P = 0.629) between high and low bTMB groups in the ICIs cohort. When ICIs were compared to chemotherapy, ICIs were found to enhance OS (HR = 0.74; 95% CI: 0.59–0.92, P = 0.006), but the improvement in PFS and ORR was only a numerical trend (PFS: HR = 0.83; 95% CI: 0.63–1.09, P = 0.173; ORR: RR = 0.92, 95% CI: 0.77–1.10, P = 0.372). NSCLC patients treated with ICIs in the high bTMB group had better survival benefits than chemotherapy patients in terms of OS (HR = 0.63; 95% CI: 0.51–0.76, P <0.001), PFS (HR = 0.63; 95% CI: 0.52–0.76, P <0.001), and ORR (RR = 1.86; 95% CI: 1.32–2.62, P <0.001), while in the low TMB group, the results were no different or even reversed (OS: HR = 0.89; 95% CI: 0.64–1.24, P = 0.485; PFS: HR = 1.21, 95% CI: 0.93–1.58, P = 0.154; ORR: RR = 0.68, 95% CI: 0.54–0.85, P = 0.001).

Conclusions

TMB could predict the enhanced survival benefit of NSCLC patients treated with ICIs; however the role of bTMB is limited at this stage. For NSCLC patients with high TMB, ICIc may be a better option than chemotherapy.
No Difference Among Inhaled Anesthetics on the Growth and Metastasis of Murine 4T1 Breast Cancers in a Mouse Model of Spontaneous Metastasis
Authors: Liu Qiuyue , Li Ru , Lin Jun
Published: February 2022

Objective: This study evaluates the effect of the commonly used inhaled anesthetics isoflurane, sevoflurane, and desflurane on the viability and migration of murine 4T1 breast cancer cells, the growth, and lung metastasis in a syngenetic model of spontaneous metastasis.

Methods: The murine 4T1 breast cancer cells were exposed to isoflurane (2%), sevoflurane (3.6%), or desflurane (10.3%) for 3 h. Cell viability was measured using the MTT assay. The migratory capacity of 4T1 cells was assessed using a scratch assay after 24 h incubation. Female balb/c mice were subjected to orthotopic implantation of 4T1 cells under anesthesia with one of the inhaled anesthetics: 2% isoflurane, 3.6% sevoflurane, or 10.3% desflurane. Subsequently, resection of primary tumors was performed under the identical anesthetic used during implantation for 3 h. Three weeks later, the mice were euthanized to harvest lungs for ex vivo bioluminescent imaging and histological analysis. Blood was collected for serum cytokine assays by ELISA.

Results: There was no difference in cell viability among isoflurane, sevoflurane, desflurane, and control groups (n = 180 for each group, P = 0.648). Sevoflurane but not isoflurane or desflurane significantly increased the migration of 4T1 cells compared to the control group (n = 18, P = 0.024). There was no difference in the growth of the orthotopically implanted primary tumors (n = 12 for the isoflurane group, n = 11 for the sevoflurane group, and for the desflurane group, P = 0.879). Surgical dissection of primary tumors in mice under anesthesia with isoflurane, sevoflurane, or desflurane led to no difference in lung metastasis following surgery (P = 0.789). No significant difference was observed among isoflurane, sevoflurane, and desflurane groups in the serum levels of IL-6 (P = 0.284), CCL-1 (P = 0.591), MCP-1 (P = 0.135), and VEGF (P = 0.354).

Conclusion: Our study demonstrated that sevoflurane increased the migration of 4T1 breast cancer cells in vitro. Inhaled anesthetics isoflurane, sevoflurane, and desflurane had no difference on the growth of primary tumor and the lung metastasis of 4T1 cells in the mouse model of spontaneous metastasis with surgical removal of primary tumors.
Effectiveness of Antiviral Therapy in Highly-Transmissible Variants of SARS-CoV-2: A Modeling and Simulation Study
Authors: Schöning Verena , Kern Charlotte , Chaccour Carlos , Hammann Felix
Published: February 2022

As of October 2021, neither established agents (e.g., hydroxychloroquine) nor experimental drugs have lived up to their initial promise as antiviral treatment against SARS-CoV-2 infection. While vaccines are being globally deployed, variants of concern (VOCs) are emerging with the potential for vaccine escape. VOCs are characterized by a higher within-host transmissibility, and this may alter their susceptibility to antiviral treatment. Here we describe a model to understand the effect of changes in within-host reproduction number R0, as proxy for transmissibility, of VOCs on the effectiveness of antiviral therapy with molnupiravir through modeling and simulation. Molnupiravir (EIDD-2801 or MK 4482) is an orally bioavailable antiviral drug inhibiting viral replication through lethal mutagenesis, ultimately leading to viral extinction. We simulated 800 mg molnupiravir treatment every 12 h for 5 days, with treatment initiated at different time points before and after infection. Modeled viral mutations range from 1.25 to 2-fold greater transmissibility than wild type, but also include putative co-adapted variants with lower transmissibility (0.75-fold). Antiviral efficacy was correlated with R0, making highly transmissible VOCs more sensitive to antiviral therapy. Total viral load was reduced by up to 70% in highly transmissible variants compared to 30% in wild type if treatment was started in the first 1–3 days post inoculation. Less transmissible variants appear less susceptible. Our findings suggest there may be a role for pre- or post-exposure prophylactic antiviral treatment in areas with presence of highly transmissible SARS-CoV-2 variants. Furthermore, clinical trials with borderline efficacious results should consider identifying VOCs and examine their impact in post-hoc analysis.
Effects of Fatigue on Postural Sway and Electromyography Modulation in Young Expert Acrobatic Gymnasts and Healthy Non-trained Controls During Unipedal Stance
Authors: da Silva Marcos Camargo , Silva Cristiano Rocha da , de Lima Felipe Fava , Lara Jéssica Rodriguez , Gustavson Jackson Paiva , Magalhães Fernando Henrique
Published: February 2022

This study investigated whether expert acrobatic gymnasts respond differentially than their non-trained counterparts during a single-legged stance task performed before and after a protocol designed to induce fatigue in the ankle plantarflexor muscles in terms of (a) postural steadiness and (b) electromyography (EMG) activation. We hypothesized that neuromuscular adaptation due to training would lead to different behavior of center of pressure (COP) and EMG quantifiers after fatigue. Twenty eight female volunteers (aged 11 to 24 years) formed two groups: expert acrobatic gymnastics athletes (GYN, n = 14) and age-matched non-gymnasts [control (CTRL), n = 14]. Fatigue of the ankle plantarflexors (dominant leg) was induced by a sustained posture (standing on the toes) until exhaustion. Traditional COP parameters (area, RMS, mean velocity, and power spectrum at low and high frequency ranges) were obtained with a force plate, and time and frequency-domain EMG parameters were obtained by surface electrodes positioned on the tibialis anterior, soleus, lateral gastrocnemius, medial gastrocnemius, vastus lateralis, biceps femoris, spinal erector and rectus abdominis muscles. The main results showed that fatigue induced a significant increase in postural oscillations in the ML axis (including RMS, velocity and frequency components of the power spectrum), with no significant effects in the AP axis. In terms of postural sway parameters (i.e., COP quantifiers), no superior balance stability was found for the GYN group as compared to CTRL, irrespective of the fatigue condition. On the other hand, the modulation of EMG parameters (in both time and frequency domains) indicated that expert acrobatic gymnastics athletes (as compared to healthy untrained matched controls) used different neuromuscular control strategies to keep their postures on single-legged quiet standing after the fatiguing protocol. The present results improve our knowledge of the mechanisms behind the interplay between fatigue and postural performance associated with the neuromuscular adaptations induced by sport practice. The design of gymnastics training might consider strategies aimed at improving the performance of specific muscles (i.e., tibialis anterior, soleus, biceps femoris, spinal erector) for which particular activation patterns were used by the acrobatic gymnastics to control single-legged quiet standing.
Culturable Bacterial Endophytes Associated With Shrubs Growing Along the Draw-Down Zone of Lake Bogoria, Kenya: Assessment of Antifungal Potential Against Fusarium solani and Induction of Bean Root Rot Protection
Authors: Mutungi Priscillar Mumo , Wekesa Vitalis Wafula , Onguso Justus , Kanga Erustus , Baleba Steve B. S. , Boga Hamadi Iddi
Published: February 2022

Vascular shrubs growing along the draw-down zones of saline lakes must develop adaptive mechanisms to cope with high salinity, erratic environmental conditions, and other biotic and abiotic stresses. Microbial endophytes from plants growing in these unique environments harbor diverse metabolic and genetic profiles that play an important role in plant growth, health, and survival under stressful conditions. A variety of bacterial endophytes have been isolated from salt tolerant plants but their potential applications in agriculture have not been fully explored. To further address this gap, the present study sought to isolate culturable bacterial endophytes from shrubs growing along the draw-down zone of Lake Bogoria, a saline alkaline lake, and examined their functional characteristics and potential in the biocontrol of the bean root rot pathogen, Fusarium solani. We collected shrubs growing within 5 m distance from the shoreline of Lake Bogoria and isolated 69 bacterial endophytes. The endophytic bacteria were affiliated to three different phyla (Firmicutes, Proteobacteria, and Actinobacteria) with a bias in the genera, Bacillus, and they showed no tissue or plant specificity. All selected isolates were positive for catalase enzyme grown in 1.5 M NaCl; three isolates (B23, B19, and B53) produced indole acetic acid (IAA) and only one isolate, B23 did not solubilize phosphate on Pikovskaya agar. Isolates, B19 and B53 exhibited more than 50% of mycelial inhibition in the dual culture assay and completely inhibited the germination of F. solani spores in co-culture assays while two isolates, B07 and B39 had delayed fungal spore germination after an overnight incubation. All isolates were able to establish endophytic association in the roots, stems, and leaves of been seedlings in both seed soaking and drenching methods. Colonization of bean seedlings by the bacterial endophytes, B19 and B53 resulted in the biocontrol of F. solani in planta, reduced disease severity and incidence, and significantly increased both root and shoot biomass compared to the control. Taxonomic identification using 16S rRNA revealed that the two isolates belong to Enterobacter hormaechei subsp., Xiangfangensis and Bacillus megaterium. Our results demonstrate the potential use of these two isolates in the biocontrol of the bean root rot pathogen, F. solani and plant growth promotion.
Premodern Confederacies: Balancing Strategic Collective Action and Local Autonomy
Authors: Birch Jennifer
Published: February 2022

A confederacy is generally understood to be a formal, institutionalized alliance of peoples who act in mutual support to achieve common ends. While the emergence and maintenance of early and pre-modern states have received tremendous scholarly attention in the social sciences, the same cannot be said for confederations. This paper examines common features of premodern confederacies as an initial effort towards developing a body of theory aimed at exploring and explaining confederacies, leagues, and other modes of collective and regional governance. The central thesis posed is that confederation was an ongoing political process that provided a means for a diverse range of political formations to achieve collective strategic goals at a distance without sacrificing autonomy. Selected case studies ranging from Pre-Columbian North America to Medieval Europe are explored to evaluate this position. The case studies show that confederacies were capable of integrating a diverse range of political formations, from tribes to kingdoms. The question of whether or not confederacies constitute ‘good government’ is considered and since the objective of a confederacy is generally not to govern, the answer depends on the political organization of its constituent parts.
Social Emotional Learning Competencies in Belize Children: Psychometric Validation Through Exploratory Structural Equation Modeling
Authors: Hinerman Krystal M. , Hull Darrell M. , Näslund-Hadley Emma I. , Mirzaei Rafe Mehri
Published: February 2022

In the nation of Belize, and in particular the south side of Belize City, the main metropolitan area of the nation, significant economic disparities have led to child and adolescent exposure to high rates of violent crime, gang activity, unsafe neighborhoods, sexual, and physical violence. Problems associated with poor Social-Emotional Character Development are especially prevalent among boys. Consequently, valid culture-relevant measures are required that identify problematic behavior for policy-based intervention and evaluation of educational programs designed to ameliorate this problem. The present study demonstrates the application of Exploratory Structural Equation Modeling to existing measures through the investigation of structural validity and generalizability of the Social-Emotional and Character Development Scale with a large sample of children from schools in Belize (N = 1,877, Ages 10–13). Exploratory structural equation modeling results demonstrate the original factor correlations were reduced, providing less biased estimates than confirmatory factor analysis (CFA). Moreover, a multi-group Exploratory Structural Equation Modeling analysis illuminates significant differences between latent factor scores of males and females for most factors. Using this newer factor analytic procedure, original factors are reconceptualized to better situate the Social Emotional Character Development Scales into the larger body of Social-Emotional Learning (SEL) competencies literature.
Collocation Use in EFL Learners’ Writing Across Multiple Language Proficiencies: A Corpus-Driven Study
Authors: Du Xiangtao , Afzaal Muhammad , Al Fadda Hind
Published: February 2022

The investigation of learners’ interlanguage could greatly contribute to the teaching of English as a foreign language and the development of teaching materials. The present study investigates the collocational profiles of large-scale written production by English learners with varied L1 backgrounds and different proficiency levels. Using the British National Corpus as reference corpus, learners’ collocation use was extracted by corpus query language and further identified by t-score via Python programming language. The collocation list consists of 2,501 make/take + noun (the direct object) collocations. Findings show that proficient learners tend to use collocations containing more semantically complicated and abstract noun elements for varied communication tasks. Moreover, advanced learners are inclined to use collocations comprised of more difficult and longer noun elements.
The Curvilinear Relationship Between Start-Up Age and Host Growth on Sharing Accommodation Platforms
Authors: Xu Zhen , Tang Li , Yu Xintao
Published: February 2022

The tourism and accommodation industry has long been a fertile field for digital entrepreneurial activities. However, sharing accommodation entrepreneurs have been ignored, whether in digital entrepreneurship or the sharing economy. This empirical study explored the relationship between start-up age and host growth based on the entrepreneurship learning theory to bridge the gap. In total, 348 hosts’ balanced panel data for 5 years were collected from the Airbnb platform. The results shown that (1) there was a curvilinear (inverted U-shaped) relationship between start-up age and host growth; (2) a critical primary growth strategy (product supply) significantly moderated the curvilinear relationship such that the inverted U-shaped relationship is less pronounced when the level of product supply is high. This study is helpful to understand digital entrepreneurs in the sharing accommodation and offers management suggestions for host growth.
Nexus Between Economic Efficiency, Healthcare, and Environmental Expenditures: A Perspective of BRI Countries
Authors: Hussain Zahid , Miao Cuifen , Zhao Zhihao , Wang Yingxuan
Published: February 2022

Public health and the environment are the most essential pillars, and play a vital role in the economy. In order to better public health, the economic and environmental atmosphere must be stable and clean, respectively. Thus, this paper emphasizes on nexus between economic, public health, and the environment. Therefore, the objective of this paper is whether healthcare and environmental expenditures affect economic efficiency and vice versa. So, this study evaluates the performance of the country's economic efficiency and investigates the effect of healthcare and environmental expenditures for 62 Belt and Road Initiative countries for the period from 1996 to 2020. Suitable input-output variables are employed under the framework of DEA-window and Malmquist Index Productivity, and Stochastic Frontier Analysis (SFA). In addition, this study estimates the relationship between economic efficiency, healthcare, and environmental expenditures by fixed and random effects models. Therefore, the analytical outcomes reveal that countries are economically efficient. On the contrary, SFA estimation concludes that countries are found to be inefficient, because higher variation is exists in efficiency change compared to technological efficiency change and total factor productivity change on average. In addition, it is worth notable that healthcare and environmental expenditures improve the country's economic efficiency. Furthermore, public health is also influenced by economic efficiency. Thus, this study suggests that countries should better utilize given resources and invest a specific portion of national income in order to improve economic efficiency.
Distributional Measures of Semantic Abstraction
Authors: Schulte im Walde Sabine , Frassinelli Diego
Published: February 2022

This article provides an in-depth study of distributional measures for distinguishing between degrees ofsemantic abstraction. Abstraction is considered a “central construct in cognitive science” (Barsalou, 2003) and a “process of information reduction that allows for efficient storage and retrieval of central knowledge” (Burgoon et al., 2013). Relying on the distributional hypothesis, computational studies have successfully exploited measures of contextual co-occurrence and neighbourhood density to distinguish between conceptual semantic categorisations. So far, these studies have modeled semantic abstraction across lexical-semantic tasks such as ambiguity; diachronic meaning changes; abstractness vs. concreteness; and hypernymy. Yet, the distributional approaches target different conceptual types of semantic relatedness, and as to our knowledge not much attention has been paid to apply, compare or analyse the computational abstraction measures across conceptual tasks. The current article suggests a novel perspective that exploits variants of distributional measures to investigate semantic abstraction in English in terms of the abstract–concrete dichotomy (e.g.,glory–banana) and in terms of the generality–specificity distinction (e.g.,animal–fish), in order to compare the strengths and weaknesses of the measures regarding categorisations of abstraction, and to determine and investigate conceptual differences.

In a series of experiments we identify reliable distributional measures for both instantiations of lexical-semantic abstraction and reach a precision higher than 0.7, but the measures clearly differ for the abstract–concrete vs. abstract–specific distinctions and for nouns vs. verbs. Overall, we identify two groups of measures, (i) frequency and word entropy when distinguishing between more and less abstract words in terms of the generality–specificity distinction, and (ii) neighbourhood density variants (especially target–context diversity) when distinguishing between more and less abstract words in terms of the abstract–concrete dichotomy. We conclude that more general words are used more often and are less surprising than more specific words, and that abstract words establish themselves empirically in semantically more diverse contexts than concrete words. Finally, our experiments once more point out that distributional models of conceptual categorisations need to take word classes and ambiguity into account: results for nouns vs. verbs differ in many respects, and ambiguity hinders fine-tuning empirical observations.
Experimental Study on the Bone Morphogenetic Protein 1-Modified Bone Marrow Mesenchymal Stem Cell Sheets to Promote Mandibular Distraction Osteogenesis
Authors: Su Zhong-Ping , Tian Lei , Shang Hong-Tao , Yang Yong , Lu Jin-Biao , Kang Yong-Jie , He Li-Sheng , Zhao Jin-Long
Published: February 2022

Objective

The present study aims to increase the concentration of genetically modified bone marrow mesenchymal stem cells (BMSCs) in the distraction osteogenesis (DO) interstitial space and induce the conversion of BMSCs to osteoblasts to improve the osteogenic efficiency in DO and shorten the treatment period.

Methods

Bone morphogenetic protein 1 (BMP-1) and green fluorescent protein (GFP) gene-modified cell sheets of BMSCs were constructed by tissue engineering. Thirty-six New Zealand white rabbits were randomly divided into three groups: group A (the blank control group), group B (the GFP group) with the injection of GFP gene-modified BMSC sheets into the DO gap, and group C (the BMP-1 group) with the injection of BMP-1 gene-modified BMSC sheets into the DO gap. Rabbits in all three groups were distracted for 5 days at a distraction rate of 2.0 mm/d, once/day. After distraction, the above-mentioned cell sheet suspension was injected into the distraction gap to observe osteogenesis, which was observed by gross specimen observation, micro-computed tomography (Micro-CT) scanning, and histomorphology.

Results

The gross specimen observation showed that all animals had smooth and continuous bone cortex in the distraction region with relatively high hardness. The osteogenesis quality or hardness was ranked from the highest to the lowest, as Group C > Group B > Group A. Micro-CT and histomorphological observation revealed that group C had better maturation and bone volume of the new bone in the DO region at weeks 3 and 6 than groups B and A.

Conclusion

BMP-1 gene-modified BMSC sheets could effectively promote the formation of new bone during rapid DO in the mandible, compensating for the poor osteogenesis caused by rapid distraction and providing a new approach to shorten the DO treatment period in clinical practice.
Urethral Stricture Formation Following Cuff Erosion of AMS Artificial Urinary Sphincter Devices: Implication for a Less Invasive Explantation Approach
Authors: Kuhlencord Katharina , Dahlem Roland , Vetterlein Malte W. , Abrams-Pompe Raisa S. , Maurer Valentin , Meyer Christian P. , Riechardt Silke , Fisch Margit , Ludwig Tim A. , Marks Phillip
Published: February 2022

Objectives

The objective of this study is to describe a standardized less invasive approach in patients with artificial urinary sphincter (AUS) explantation due to cuff erosion and analyze success and urethral stricture rates out of a prospective database. Evidence regarding complication management is sparse with heterogenous results revealing high risk of urethral stricture formation despite simultaneous urethroplasty in case of AUS explantation.

Patients and Methods

Data of all patients undergoing AUS implantation due to stress urinary incontinence (SUI) in our tertiary center were prospectively collected from 2009 to 2015. In case of cuff erosion, AUS explantation was carried out in an institutional standardized strategy without urethroplasty, urethral preparation or mobilization nor urethrorrhaphy. Transurethral and suprapubic catheters were inserted for 3 weeks followed by radiography of the urethra. Further follow-up (FU) consisted of pad test, uroflowmetry, postvoiding residual urine (PVR), and radiography. Primary endpoint was urethral stricture rate.

Results

Out of 235 patients after AUS implantation, 24 (10.2%) experienced cuff erosion with consecutive explantation and were available for analysis. Within a median FU of 18.7 months after AUS explantation, 2 patients (8.3%) developed a urethral stricture. The remaining 22 patients showed a median Qmax of 17 ml/s without suspicion of urethral stricture. Median time to reimplantation was 4 months (IQR 3-4).

Conclusion

We observed a considerably low stricture formation and could not prove an indication for primary urethroplasty nor delay in salvage SUI treatment possibilities. Therefore, the presented standardized less invasive explantation strategy with consequent urinary diversion seems to be safe and effective and might be recommended in case of AUS cuff erosion.
Artificial Urinary Sphincter Is Better Than Slings for Moderate Male Stress Urinary Incontinence With Acceptable Complication Rate: A Systematic Review and Meta-Analysis
Authors: Lin Lede , Sun Wenjin , Guo Xiaotong , Zhou Liang
Published: February 2022

Background

This meta-analysis aimed to compare the efficacy of artificial urinary sphincter (AUS) and slings for the treatment of moderate male stress urinary incontinence (SUI) based on existing data.

Methods

The study was in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. We searched the widely acknowledged database including PubMed, Embase (Ovid version), Medline (Ovid version), and Cochrane Central Register of Controlled Trials (till February 2021). Male patients with moderate SUI who underwent AUS or slings procedure over 18 years old and had been monitored with a mean follow-up time of at least 12 months were included. The primary outcome was success rate defined as daily pad use with 0–1 pad/d postoperatively. Articles with congruent outcomes were suitable for inclusion. The secondary outcome included complication rate of infection, erosion, acute urinary retention, and surgical revision.

Results

Five studies with a total of 509 patients (295 for slings and 214 for AUS) were recruited. The success rate was higher in AUS with an odds ratio (OR) = 0.57 (95% CI: 0.36–0.90). As for the overall complication rate, no significant difference was discovered between slings and AUS groups (OR = 1.06, 95% CI: 0.58–1.92, P = 0.86).

Conclusion

To conclude, AUS was better than slings for moderate male SUI treatment according to daily pad use with an acceptable complication rate. The slings also had clinical value and were options when aging male patients were AUS naive and refused inserted mechanical devices. High-quality pieces of evidence are needed to confirm the efficacy of AUS and slings in moderate male SUI.

Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=271203, identifier: CRD42021271203.
Self-Usage of antibiotics in medical and non-medical students of Islamabad and Rawalpindi
Authors:   Prime Institute of Health Sciences, Hashmi Najia Zainab , Nawaz Jannat ,   Riphah Rehabilitation Center, Sheraz Suman ,   Riphah College of Rehabilitation & Allied Health Sciences, Riphah International University, Islamabad, Razzaq Aisha ,   Riphah College of Rehabilitation & Allied Health Sciences, Riphah International University, Islamabad
Published: February 2022

Background: Self-usage of drugs is defined as the use of the drugs for the treatment of self-diagnosed signs or symptoms and the continued or intermittent use of the prescribed drug for the acute or chronic signs and symptoms. Use of self-medication is normally done when people or consumers don't think the need of visiting a doctor or it might be because they think that they can handle their symptoms on their own. Objective: To determine the practice and usage of antibiotics and its associated factors in medical and nonmedical students of Rawalpindi and Islamabad. Method: The comparative cross-sectional survey was conducted at medical and non-medical faculties of Riphah International University from February- July 2018, comprising students aged 20-30 years. Both genders were selected through non probability purposive sampling. A self-designed questionnaire was used to obtain the data. Data was analyzed through SPSS version 19. Results: Out of 926 students, practice of self-medication among medical students was higher 324 (35.0%) as compared to non-medical students 261 (28.2%). Practice of antibiotics in males was higher 348 (37.6%) as compared to females 237 (25.6%). Conclusion: The frequency of self-medication with antibiotics is higher in medical students particularly in male students.
Incidence and etiology of traumatic spinal cord injury in Khyber Pakhtunkhwa from 2010 to 2020: A cross-sectional study
Authors:   City University of Science and Information Technology, Peshawar, Jaffar Muhammad , Ayaz Mahnoor ,   Iqra National University, Peshawar, Haleem Farhan ,   City University of Science and Information Technology, Peshawar, Khan Fizah Mahnoor ,   Riphah College of Rehabilitation and Allied Health Sciences, Riphah International University, Islamabad Pakistan, Irfan Muhammad ,   City University of Science and Information Technology, Peshawar, Khalid Zohaib ,   City University of Science and Information Technology, Peshawar
Published: February 2022

Background: Spinal cord injury (SCI) is a traumatic occurrence that causes motor and sensory deficits for the rest of one's life. Despite many investigators' best attempts to establish genuine therapeutic interactions, traumatic SCI is a traumatic experience after which recovery of function is restricted. Quadriplegia occurs when an injury occurs above the first thoracic vertebra, so both the upper and lower limbs are paralyzed. However, if the lesion occurs below the first thoracic vertebra, paraplegia occurs, and the patient's condition can range from limited lower-limb mobility to total paralysis of both lower limbs. Objective: To determine the incidence rate and etiology of traumatic spinal cord injuries in Khyber Pakhtunkhwa from 2010 to 2020. Methods: This is a descriptive cross-sectional study, which was performed at different rehabilitation centers of KPK from September 2010 to November 2020. Patients with traumatic SCI between 2010 and 2020, who were residents of Khyber Pakhtunkhwa, were included while patients with other etiology of SCI or residents of other provinces were excluded from the study. Secondary data was collected through self-structured performa. Using SPSS version 23, the collected data was analyzed to obtain the collected data regarding our topic. Results: Total of 2022 patients were included in the study; their mean age was 33.3 years. Males were 1631 patients (80.6%), while females were 319 patients (19.3 %). Fall from the height (33.1 %) was the most common cause of SCI which was followed by RTA (26.8%) and firearm injury (FAI) (21.5 %) respectively. Thoracic (55.29 %) was the most common level injured. Complete injuries were 1588 (78.5 %) and incomplete ones were 429 (21.21 %). Most patients were from Peshawar District (20.7 %). Conclusion: This study concludes that fall from height was the main cause of Traumatic Spinal Cord Injury, followed by road traffic accidents and firearm injuries. Males were at higher risk of Traumatic Spinal Cord Injury.
Quantitative Lithiation Depth Profiling in Silicon Containing Anodes Investigated by Ion Beam Analysis
Authors: Möller Sören , Joo Hyunsang , Rasinski Marcin , Mann Markus , Figgemeier Egbert , Finsterbusch Martin
Published: February 2022

The localisation and quantitative analysis of lithium (Li) in battery materials, components, and full cells are scientifically highly relevant, yet challenging tasks. The methodical developments of MeV ion beam analysis (IBA) presented here open up new possibilities for simultaneous elemental quantification and localisation of light and heavy elements in Li and other batteries. It describes the technical prerequisites and limitations of using IBA to analyse and solve current challenges with the example of Li-ion and solid-state battery-related research and development. Here, nuclear reaction analysis and Rutherford backscattering spectrometry can provide spatial resolutions down to 70 nm and 1% accuracy. To demonstrate the new insights to be gained by IBA, SiOx-containing graphite anodes are lithiated to six states-of-charge (SoC) between 0–50%. The quantitative Li depth profiling of the anodes shows a linear increase of the Li concentration with SoC and a match of injected and detected Li-ions. This unambiguously proofs the electrochemical activity of Si. Already at 50% SoC, we derive C/Li = 5.4 (< LiC6) when neglecting Si, proving a relevant uptake of Li by the 8 atom % Si (C/Si ≈ 9) in the anode with Li/Si ≤ 1.8 in this case. Extrapolations to full lithiation show a maximum of Li/Si = 1.04 ± 0.05. The analysis reveals all element concentrations are constant over the anode thickness of 44 µm, except for a ~6-µm-thick separator-side surface layer. Here, the Li and Si concentrations are a factor 1.23 higher compared to the bulk for all SoC, indicating preferential Li binding to SiOx. These insights are so far not accessible with conventional analysis methods and are a first important step towards in-depth knowledge of quantitative Li distributions on the component level and a further application of IBA in the battery community.
Effectiveness of Whole-Body Vibration Combined with Multicomponent Training on the Risk of Falls and Quality of Life in Elderly Women with Osteoporosis: Study Protocol for a Randomized Controlled Clinical Trial
Authors: Souto Braz Rúbia Rayanne , Campos Shirley Lima , Villela Débora Wanderley , Antonino Gabriel Barreto , Araújo Batista Pâmella Karolline , Guerino Marcelo Renato , Rodrigues François Talles Medeiros , Pereira Alves Kennedy Freitas , Duarte João Victor Torres , de Andrade Silva Diana , Lima Daniel Florentino , da Silva Arthur Felipe Freire , de Oliveira Karla Cybele Vieira , dos Santos Edy Kattarine Dias , Leite Wagner Souza , de Lucena Larissa Coutinho , de Lima Ferreira Ana Paula , Monte-Silva Kátia , das Graças Rodrigues de Araújo Maria , Taiar Redha
Published: February 2022

Osteoporosis and the risk of falls increase the risk of fractures and events of falls. Prescriptions and programs for different forms of exercise have different impacts on the risk of falls, and exercises from multiple categories of whole-body vibration can be effective. This study aims to evaluate the effectiveness of whole-body vibration (WBV) protocol combined with multicomponent training (MCT) in elderly women with osteoporosis and their history of falls. Our proposal is a protocol for a randomized clinical trial, divided into two stages: First, development of a protocol for WVB combined with MCT for elderly women with osteoporosis and a history of falls, under the Guidelines of the American College of Sports Medicine, and following the recommendations of the Standard Protocol Items Recommendations for Interventional Trials (SPIRIT), and second, a randomized controlled clinical trial following the Consolidated Standards of Reporting Trials (CONSORT). This trial will have implications for the effectiveness of a vibration protocol combined with multicomponent exercise on the risk of falls and quality of life for older women with osteoporosis. We expect that adding full-body vibration to an exercise protocol will decrease the risk of falls and improve participants’ quality of life, as well as their strength, balance, and functional capacity.
An Image Encryption Scheme Based on Logistic Quantum Chaos
Authors: Wang Yu , Chen Liquan , Yu Kunliang , Gao Yuan , Ma Yang
Published: February 2022

This paper proposes an image encryption scheme based on logistic quantum chaos. Firstly, we use compressive sensing algorithms to compress plaintext images and quantum logistic and Hadamard matrix to generate the measurement matrix. Secondly, the improved flexible representation of the quantum images (FRQI) encoding method is utilized for encoding the compressed image. The pixel value scrambling operation of the encoded image is realized by rotating the qubit around the axis. Finally, the quantum pixel is encoded into the pixel value in the classical computer, and the bit-level diffusion and scrambling are performed on it. Numerical analysis and simulation results show that our proposed scheme has the large keyspace and strong key sensitivity. The proposed scheme can also resist standard attack methods such as differential attacks and statistical analysis.
Cost-Sensitive KNN Algorithm for Cancer Prediction Based on Entropy Analysis
Authors: Song Chaohong , Li Xinran
Published: February 2022

Early diagnosis of cancer is beneficial in the formulation of the best treatment plan; it can improve the survival rate and the quality of patient life. However, imaging detection and needle biopsy usually used not only find it difficult to effectively diagnose tumors at early stage, but also do great harm to the human body. Since the changes in a patient’s health status will cause changes in blood protein indexes, if cancer can be diagnosed by the changes in blood indexes in the early stage of cancer, it can not only conveniently track and detect the treatment process of cancer, but can also reduce the pain of patients and reduce the costs. In this paper, 39 serum protein markers were taken as research objects. The difference of the entropies of serum protein marker sequences in different types of patients was analyzed, and based on this, a cost-sensitive analysis model was established for the purpose of improving the accuracy of cancer recognition. The results showed that there were significant differences in entropy of different cancer patients, and the complexity of serum protein markers in normal people was higher than that in cancer patients. Although the dataset was rather imbalanced, containing 897 instances, including 799 normal instances, 44 liver cancer instances, and 54 ovarian cancer instances, the accuracy of our model still reached 95.21%. Other evaluation indicators were also stable and satisfactory; precision, recall, F1 and AUC reach 0.807, 0.833, 0.819 and 0.92, respectively. This study has certain theoretical and practical significance for cancer prediction and clinical application and can also provide a research basis for the intelligent medical treatment.
Effect of Manufacturing Inaccuracies on the Wake Past Asymmetric Airfoil by PIV
Authors: Duda Daniel , Yanovych Vitalii , Tsymbalyuk Volodymyr , Uruba Václav
Published: February 2022

The effect of manufacturing geometry deviations on the flow past a NACA 64(3)-618 asymmetric airfoil is studied. This airfoil is 3D printed according to the coordinates from a public database. An optical high-precision 3D scanner, GOM Atos, measures the difference from the idealized model. Based on this difference, another model is prepared with a physical output closer to the ideal model. The velocity in the near wake (0–0.4 chord) is measured by using the Particle Image Velocimetry (PIV) technique. This work compares the wakes past three airfoil realizations, which differ in their similarity to the original design (none of the realizations is identical to the original design). The chord-based Reynolds number ranges from 1.6×104 to 1.6×105. The ensemble average velocity is used for the determination of the wake width and for the rough estimation of the drag coefficient. The lift coefficient is measured directly by using force balance. We discuss the origin of turbulent kinetic energy in terms of anisotropy (at least in 2D) and the length-scales of fluctuations across the wake. The spatial power spectral density is shown. The autocorrelation function of the cross-stream velocity detects the regime of the von Karmán vortex street at lower velocities.