bluuebunny/crossref_metadata_2025 huggingface dataset:
Betaxolol as a Potent Inhibitor of NDM-1-Positive E. coli That Synergistically Enhances the Anti-Inflammatory Effect in Combination with Meropenem
Authors: Sun Jichao , Ren Shangjie , Yang Yaozu , Li Xiaoting , Zhang Xiuying
Published: August 2023

With significant human and economic losses, increasing bacterial resistance is a serious global threat to human life. Due to their high efficacy, broad spectrum, and cost-effectiveness, beta-lactams are widely used in the clinical management of bacterial infection. The emergence and wide spread of New Delhi metallo-β-lactamase (NDM-1), which can effectively inactivate β-lactams, has posed a challenge in the design of effective new antimicrobial treatments. Medicine repurposing is now an important tool in the development of new alternative medicines. We present a known glaucoma therapeutic, betaxolol (BET), which with a 50% inhibitory concentration (IC50) of 19.3 ± 0.9 μM significantly inhibits the hydrolytic activity of the NDM-1 enzyme and may represent a potential NDM-1 enzyme inhibitor. BET combined with meropenem (MEM) showed bactericidal synergism in vitro. The efficacy of BET was further evaluated against systemic bacterial infections in BALB/c mice. The results showed that BET+MEM decreased the numbers of leukocytes and inflammatory factors in peripheral blood, as well as the organ bacterial load and pathological damage. Molecular docking and kinetic simulations showed that BET can form hydrogen bonds and hydrophobic interactions directly with key amino acid residues in the NDM-1 active site. Thus, we demonstrated that BET inhibited NDM-1 by competitively binding to it and that it can be developed in combination with MEM as a new therapy for the management of infections caused by medicine-resistant bacteria.
Metabolomics: Perspectives on Clinical Employment in Autism Spectrum Disorder
Authors: Siracusano Martina , Arturi Lucrezia , Riccioni Assia , Noto Antonio , Mussap Michele , Mazzone Luigi
Published: August 2023

Precision medicine is imminent, and metabolomics is one of the main actors on stage. We summarize and discuss the current literature on the clinical application of metabolomic techniques as a possible tool to improve early diagnosis of autism spectrum disorder (ASD), to define clinical phenotypes and to identify co-occurring medical conditions. A review of the current literature was carried out after PubMed, Medline and Google Scholar were consulted. A total of 37 articles published in the period 2010–2022 was included. Selected studies involve as a whole 2079 individuals diagnosed with ASD (1625 males, 394 females; mean age of 10, 9 years), 51 with other psychiatric comorbidities (developmental delays), 182 at-risk individuals (siblings, those with genetic conditions) and 1530 healthy controls (TD). Metabolomics, reflecting the interplay between genetics and environment, represents an innovative and promising technique to approach ASD. The metabotype may mirror the clinical heterogeneity of an autistic condition; several metabolites can be expressions of dysregulated metabolic pathways thus liable of leading to clinical profiles. However, the employment of metabolomic analyses in clinical practice is far from being introduced, which means there is a need for further studies for the full transition of metabolomics from clinical research to clinical diagnostic routine.
Development of Indications for Endoscopic Spine Surgery: An Overview
Authors: Wirth Fernanda , Bergamaschi Esthael Cristina Querido Avelar , Forti Fábio da Silva , Bergamaschi João Paulo Machado
Published: August 2023

Endoscopic spine surgery (ESS) began more than 20 years ago as percutaneous endoscopic discectomy and has evolved to the present day. This technique offers many advantages, including a short hospital stay, minimal trauma and blood loss, the option of local or epidural anesthesia with sedation, a low rate of nosocomial infections, early recovery, and a quick return to work and daily activities. The success rate of this technique ranges from 83% to 90% in operated patients. This article aims to provide an overview of indications, versatility of the technique, advantages, contraindications and limitations, and also a reflection on the possible contraindications and limitations of the technique.
A Secure and Privacy-Preserving Blockchain-Based XAI-Justice System
Authors: Demertzis Konstantinos , Rantos Konstantinos , Magafas Lykourgos , Skianis Charalabos , Iliadis Lazaros
Published: August 2023

Pursuing “intelligent justice” necessitates an impartial, productive, and technologically driven methodology for judicial determinations. This scholarly composition proposes a framework that harnesses Artificial Intelligence (AI) innovations such as Natural Language Processing (NLP), ChatGPT, ontological alignment, and the semantic web, in conjunction with blockchain and privacy techniques, to examine, deduce, and proffer recommendations for the administration of justice. Specifically, through the integration of blockchain technology, the system affords a secure and transparent infrastructure for the management of legal documentation and transactions while preserving data confidentiality. Privacy approaches, including differential privacy and homomorphic encryption techniques, are further employed to safeguard sensitive data and uphold discretion. The advantages of the suggested framework encompass heightened efficiency and expediency, diminished error propensity, a more uniform approach to judicial determinations, and augmented security and privacy. Additionally, by utilizing explainable AI methodologies, the ethical and legal ramifications of deploying intelligent algorithms and blockchain technologies within the legal domain are scrupulously contemplated, ensuring a secure, efficient, and transparent justice system that concurrently protects sensitive information upholds privacy.
Crystal Structures of DNA Intercalating Agents Dipyrido[3,2-f:2′,3′-h]quinoxaline (dpq), (Benzo[i]dipyrido[3,2-a:2′,3′c]phenazine (dppn), and [Ir(ppy)2(dppn)][PF6] (Where Hppy = 2-Phenylpyridine)
Authors: James Marisa , Shevlin Madelyn R. , Green Thomas B. , Smart Megan M. , McMillen Colin D. , Pienkos Jared A.
Published: August 2023

Pyrazino-phenanthroline ligands are commonly used with transition metals as DNA intercalation agents. Herein, we report the characterization of two commonly utilized pyrazino-phenanthroline ligands, dipyrido[3,2-f:2′,3′-h]quinoxaline (dpq) and (benzo[i]dipyrido[3,2-a:2′,3′c]phenazine (dppn), by single-crystal X-ray diffraction. Additionally, the characterization of [Ir(ppy)2(dppn)][PF6], where Hppy = 2-phenylpyridine, by single-crystal X-ray diffraction is described. Both the dpq and dppn ligands crystallize as chloroform solvates where the chloroform molecule occupies the equivalent binding pocket of a metal in metal complexes of these ligands. These pyrazino-phenanthrolines are largely planar, with the dppn ligand displaying a slight twist. When the dppn ligand is coordinated to iridium(III), the dppn ligand on the resulting complex displays a significant degree of bending along the longitudinal direction of the ligand. This iridium (III) complex crystallizes as a CH2Cl2 and Et2O solvate and due to the volatility of these solvents these crystals are only stable for a few seconds outside of the mother liquor. The structures of the free ligands and the [Ir(ppy)2(dppn)][PF6] complex all display extensive π stacking interactions.
Enhancing the Tribo-Mechanical Performance of LDPE Nanocomposites Utilizing Low Loading Fraction Al2O3/SiC Hybrid Nanostructured Oxide Fillers
Authors: Alnaser Ibrahim A. , Fouly Ahmed , Aijaz Muhammad Omer , Mohammed Jabair A. , Elsheniti Mahmoud B. , Ragab Sameh A. , Abdo Hany S.
Published: August 2023

This research work highlights the tribomechanical investigations of using a low loading fraction of two ceramics combinations, Alumina (Al2O3) and Silicon Carbide (SiC) as reinforcement for Low-density Polyethylene (LDPE) matrix. The hybrid additives with different weight percentages (0.1 + 0.1, 0.25 + 0.25 and 0.5 + 0.5 wt%) were mixed with LDPE matrix and the degree of homogeneity was controlled using double-screw extruder prior to fabricating the composite samples via the injection molding machine. The nanoparticles fillers were characterized by field emission scanning electron microscope (FESEM), EDX and particle size analyzer to check its morphology, composition and size distribution. Thermogravimetric analyzer (TGA) and melting flow index (MFI) were performed for the fabricated nanocomposites samples. The mechanical properties of the nanocomposite were evaluated by performing tensile test, bending test and Shore-D hardness test, while the tribological performance was investigated using a ball on desk apparatus under different applied loads and sliding times. Moreover, in order to confirm the load-carrying capability of the composite, contact stresses was measured via finite element model using ANSYS software. The results show that the incorporation of low fraction hybrid ceramic nanoparticles can contributed positively in the tribological and mechanical properties. Based on the experimental results, the maximum improvement in the tensile strength was 5.38%, and 8.15% for hardness LDPE with 0.5 Al2O3 and 0.5 SiC, while the lowest coefficient of friction was noticed under normal load of 10 N, which was approximately 12.5% for the same composition. The novel approach of incorporating low fraction hybrid ceramic nanoparticles as reinforcement for LDPE matrix is investigated, highlighting their positive contributions to the tribological and mechanical properties of the resulting nanocomposites.
Prostate Biopsy in the Case of PIRADS 5—Is Systematic Biopsy Mandatory?
Authors: Malewski Wojciech , Milecki Tomasz , Szempliński Stanisław , Tayara Omar , Kuncman Łukasz , Kryst Piotr , Nyk Łukasz
Published: August 2023

Combining systematic biopsy (SB) with targeted biopsy (TB) in the case of a positive result from multiparametric magnetic resonance imaging (mpMRI) is a matter of debate. The Prostate Imaging Reporting and Data System (PIRADS) score of 5 indicates the highest probability of clinically significant prostate cancer (csPC) detection in TB. Potentially, omitting SB in the case of PIRADS 5 may have a marginal impact on the csPC detection rate. The aim of this study was to determine whether SB can be avoided in the case of PIRADS 5 and to identify potential factors allowing for performing TB only. This cohort study involved n = 225 patients with PIRADS 5 on mpMRI (PIRADS 2.0/2.1) who underwent transperineal or transrectal combined biopsy (CB). CsPC was diagnosed in 51.6% (n = 116/225) of cases. TB and SB resulted in the detection of csPC in 48% (n = 108/225) and 20.4% (n = 46/225) of cases, respectively (TB vs. SB, p < 0.001). When the TB was positive, SB detected csPC in n = 38 of the cases (38/108 = 35%). SB added to TB significantly improved csPC detection in 6.9% of cases in absolute terms (n = 8/116) (TB vs. CB, p = 0.008). The multivariate regression model proved that the significant predictors of csPC detection via SB were the densities of the prostate-specific antigen—PSAD > 0.17 ng/mL2 (OR = 4.038, 95%CI: 1.568–10.398); primary biopsy setting (OR = 2.818, 95%CI: 1.334–5.952); and abnormal digital rectal examination (DRE) (OR = 2.746, 95%CI: 1.328–5.678). In a primary biopsy setting (n = 103), SB detected 10% (n = 6/60) of the additional cases of csPC (p = 0.031), while in a repeat biopsy setting (n = 122), SB detected 3.5% (n = 2/56) of the additional cases of csPC (p = 0.5). In the case of PSAD > 0.17 ng/mL2 (n = 151), SB detected 7.4% (n = 7/95) of additional cases of csPC (p = 0.016), while in the case of PSAD < 0.17 ng/mL2 (n = 74), SB detected 4.8% (n = 1/21) of the additional cases of csPC (p = 1.0). The omission of SB had an impact on the csPC diagnosis rate in patients with PIRADS 5 score lesions. Patients who have already undergone prostate biopsy and those with low PSAD are at a lower risk of missing csPC when SB is avoided. However, performing TB only may result in missing other csPC foci located outside the index lesion, which can alter treatment decisions.
The Role of Early Serum Biomarkers and Clinical Rating Scales in the Prediction of Delayed Cerebral Ischaemia and Short-Term Outcome after Aneurysmal Subarachnoid Haemorrhage: Single Centre Experience
Authors: Burzyńska Małgorzata , Uryga Agnieszka , Woźniak Jowita , Załuski Rafał , Robba Chiara , Goździk Waldemar
Published: August 2023

Considering the variety of complications that arise after aneurysmal subarachnoid haemorrhage (aSAH) and the complex pathomechanism of delayed cerebral ischaemia (DCI), the task of predicting the outcome assumes a profound complexity. Therefore, there is a need to develop early predictive and decision-making models. This study explores the effect of serum biomarkers and clinical scales on patients’ outcomes and their interrelationship with DCI and systemic complications in aSAH. This was a retrospective analysis including aSAH patients admitted to the Wroclaw University Hospital (Wrocław, Poland) from 2011 to 2020. A good outcome was defined as a modified Rankin Scale (mRS) score of 0–2. The prediction of the development of DCI and poor outcome was conducted using logistic regression as a standard model (SM) and random forest as a machine learning method (ML). A cohort of 174 aSAH patients were included in the analysis. DCI was diagnosed in 79 (45%) patients. Significant differences between patients with poor vs. good outcome were determined from their levels of albumin (31 ± 7 vs. 35 ± 5 (g/L); p < 0.001), D-dimer (3.0 ± 4.5 vs. 1.5 ± 2.8 (ng/mL); p < 0.001), procalcitonin (0.2 ± 0.4 vs. 0.1 ± 0.1 (ng/mL); p < 0.001), and glucose (169 ± 69 vs. 137 ± 48 (nmol/L); p < 0.001). SM for DCI prediction included the Apache II scale (odds ratio [OD] 1.05; 95% confidence interval [CI] 1.00–1.09) and albumin level (OD 0.88; CI 0.82–0.95). ML demonstrated that low albumin level, high Apache II scale, increased D-dimer and procalcitonin levels had the highest predictive values for DCI. The integration of clinical parameters and scales with a panel of biomarkers may effectively facilitate the stratification of aSAH patients, identifying those at high risk of secondary complications and poor outcome.
Association between Locomotive Syndrome and Hearing Loss in Community-Dwelling Adults
Authors: Ito Sadayuki , Nakashima Hiroaki , Segi Naoki , Ouchida Jun , Ishizuka Shinya , Takegami Yasuhiko , Yoshida Tadao , Hasegawa Yukiharu , Imagama Shiro
Published: August 2023

The relationship between hearing and motor function as a function of aging is unclear. Therefore, we aimed to clarify the relationship between age-related hearing loss and locomotive syndrome. In total, 240 participants aged ≥40 years, whose hearing acuity and motor function had been measured, were included in this study. Patients with a hearing acuity of <35 dB and ≥35 dB were categorized into normal and low hearing acuity groups, respectively. Motor function was compared according to sex between the groups. Among men, those in the low hearing acuity group (51/100) were older, had a significantly slower walking speed, and had a higher prevalence of locomotive syndrome than those in the normal group. Among women, those in the low hearing group (14/140) were older and had a significantly slower gait speed than those in the normal group. The multivariate analysis showed that, in the low hearing acuity group, age and gait speed were risk factors in men, while age was the only risk factor in women. In conclusion, hearing loss was associated with walking speed. The association between hearing loss and locomotive syndrome was observed only in men. In the multivariate analysis, hearing loss was associated with walking speed only in men.
ASA Allergy and Desensitization Protocols in the Management of CAD: A Review of Literature
Authors: Verdoia Monica , Gioscia Rocco , Nardin Matteo , De Luca Giuseppe
Published: August 2023

Acetylsalicylic acid (ASA) hypersensitivity still represents one of the major deals for patients with atherosclerotic cardiovascular disease (ASHD), especially for those requiring percutaneous coronary interventions in the absence of validated alternative options. Despite symptoms after ASA administration being reported in 6–20% of cases, true ASA allergy only represents a minority of the patients, pointing to the importance of challenge tests and potential strategies for tolerance induction. ASA desensitization protocols were proposed several decades ago, with accumulating the literature on their use in patients undergoing PCI either for chronic disease or acute coronary syndromes. Nevertheless, the promising results of the studies and meta-analyses have not been validated so far by the support of large-scale randomized trials or unique indications from guidelines. Therefore, ASA desensitization is still largely unapplied, leaving the management of ASA hypersensitivity to the individualized approach of cardiologists.
Anti-ADAMTS13 Autoantibodies: From Pathophysiology to Prognostic Impact—A Review for Clinicians
Authors: Dainese Cristina , Valeri Federica , Bruno Benedetto , Borchiellini Alessandra
Published: August 2023

Thrombotic thrombocytopenic purpura (TTP) is a fatal disease in which platelet-rich microthrombi cause end-organ ischemia and damage. TTP is caused by markedly reduced ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) activity. ADAMTS13 autoantibodies (autoAbs) are the major cause of immune TTP (iTTP), determining ADAMTS13 deficiency. The pathophysiology of such autoAbs as well as their prognostic role are continuous objects of scientific studies in iTTP fields. This review aims to provide clinicians with the basic information and updates on autoAbs’ structure and function, how they are typically detected in the laboratory and their prognostic implications. This information could be useful in clinical practice and contribute to future research implementations on this specific topic.
Surface Modification Methods of Self-Cured Acrylic Resin Repaired with Resin Composite Using a Universal Adhesive
Authors: Klaisiri Awiruth , Maneenacarith Apichai , Krajangta Nantawan , Sukkee Alysha , Hardy Nannita Stephannie , Wutikhun Tuksadon , Supachartwong Chayaporn
Published: August 2023

This research study’s purpose was to evaluate the mechanical and chemical surface treatment methods for self-cured acrylic resin repaired with a resin composite employing a universal adhesive agent. Eighty self-cured acrylic resins were built and designed into eight groups of ten specimens and surface conditioned using sandblasting (SB) and/or with methylmethacrylate monomer (MMA) and/or universal adhesive (UA) as follows: Group 1, non-surface modified; Group 2, SB; Group 3, UA; Group 4, SB + UA; Group 5, MMA; Group 6, SB + MMA; Group 7, MMA + UA; Group 8, SB + MMA + UA. A template was put on the specimen center, and the pushed resin composites. Mechanical testing machinery was used to examine the samples’ shear bond strength (SBS) values. To examine failure patterns, the debonded specimen surfaces were examined using a scanning electron microscope. The one-way ANOVA method was used to evaluate these data, and Tukey’s test was used to determine the significance level (p < 0.05). The highest SBS was obtained in Group 8 (27.47 ± 2.15 MPa); however, it was statistically equivalent to Group 7 (25.85 ± 0.34 MPa). Group 1 (4.45 ± 0.46 MPa) had the lowest SBS, but it was not statistically significant compared to Group 2 (5.26 ± 0.92 MPa). High SBS values were frequently correlated with cohesive patterns. The application of MMA prior to UA is the best method for increasing the SBS between self-cured acrylic resin and resin composite interfaces. However, the use of SB is not significantly different from not using SB.
Current Advances in Bovine In Vitro Maturation and Embryo Production Using Different Antioxidants: A Review
Authors: Naspinska Roksana , Moreira da Silva Maria Helena , Moreira da Silva Fernando
Published: August 2023

In vitro maturation (IVM) is one of the most important steps in in vitro embryo production (IVEP). It is a complicated procedure in which nuclear and cytoplasmatic changes in oocytes appear. In order to carry out the in vitro maturation procedure correctly, it is necessary to provide the oocytes with as close to a natural (in vivo) environment as possible. Many factors contribute to the overall poor quality of in vitro-matured oocytes. One important factor may be oxidative stress (OS). The generation of oxidants, such as reactive oxygen species, is common under culture conditions. The solution for OC treatment and prevention is antioxidants. In the last 5 years, many studies have examined different antioxidants and their effects on in vitro maturation of oocytes and embryo production. The aim of this systematic review was to present the achievements of scientific research in the last five years, in which the effects of many antioxidants were tested on bovine oocyte maturation and embryo production.
Electron Microscopy (EM) Analysis of Collagen Fibers in the Peri-Implant Soft Tissues around Two Different Abutments
Authors: Covani Ugo , Giammarinaro Enrica , Di Pietro Natalia , Boncompagni Simona , Rastelli Giorgia , Romasco Tea , Velasco-Ortega Eugenio , Jimenez-Guerra Alvaro , Iezzi Giovanna , Piattelli Adriano , Marconcini Simone
Published: August 2023

The design of the implant prosthesis–abutment complex appears crucial for shaping healthy and stable peri-implant soft tissues. The aim of the present animal study was to compare two implants with different healing abutment geometries: a concave design (TEST) and a straight one (CTRL). Transmission electron microscopy (TEM) was used to quantify the three-dimensional topography and morphological properties of collagen at nanoscale resolution. 2 swine were included in the experiment and 6 implants per animal were randomly placed in the left or right hemimandible in either the physiologically mature bone present between the lower canine and first premolar or in the mandibular premolar area, within tooth extraction sites. Each CTRL implant was positioned across from its respective TEST implant on the other side of the jaw. After 12 weeks of healing, 8 specimens (4 CTRL and 4 TEST) were retrieved and prepared for histological and TEM analysis. The results showed a significantly higher percentage of area covered by collagen bundles and average bundle size in TEST implants, as well as a significant decrease in the number of longitudinally oriented bundles with respect to CTRL implants, which is potentially due to the larger size of TEST bundles. These data suggest that a concave transmucosal abutment design serves as a scaffold, favoring the deposition and growth of a well-organized peri-implant collagen structure over the implant platform in the early healing phase, also promoting the convergence of collagen fibers toward the abutment collar.
Online Estimation of Ship Dimensions by Combining Images with AIS Reports
Authors: Huang Zishuo , Hu Qinyou , Lu Lan , Mei Qiang , Yang Chun
Published: August 2023

Ship dimensions are an important component of static AIS information, and are a key factor in identifying the risks of ship collisions. We describe a method of extracting and correcting ship contour information using inland waterway surveillance video combined with AIS information that does not depend on ship dimension data. A lightweight object detection model was used to determine the ship’s position in an image. Dynamic AIS information was included to produce multigroup control points, solve the optimal homography matrix, and create a transformation model to map image coordinates onto water surface coordinates. A semantic segmentation DeepLabV3+ model was used to determine ship contours from the images, and the actual dimensions of the ship contours were calculated using homography matrix transformation. The mAP of the proposed object detection model and the MIoU of the semantic segmentation model were 86.73% and 91.07%, respectively. The calculation error of the ship length and width were 5.8% and 7.4%, respectively. These statistics indicate that the proposed method rapidly and accurately detected target ships in images, and that the model estimated ship dimensions within a reasonable range.
On the Definition of a Comprehensive Technology-Informed Accessibility Metric for Offshore Renewable Energy Site Selection
Authors: Konuk Erim-Bora , Centeno-Telleria Manu , Zarketa-Astigarraga Ander , Aizpurua Jose-Ignacio , Giorgi Giuseppe , Bracco Giovanni , Penalba Markel
Published: August 2023

Despite the important role of offshore renewable energies (OREs) in the energy transition, the economical viability is still unclear. Therefore, an appropriate site selection is crucial. Besides the energy potential, the impact of operation and maintenance (O&M) aspects on the location can be critical. Accessibility is one of the most relevant aspects for O&M, assessing the feasibility to access the ORE farm. However, traditional accessibility assessment metrics do not allow a comprehensive evaluation. Therefore, the present paper suggests a novel, technology-informed metric, incorporating the overall set of most critical aspects, i.e., metocean conditions, visibility due to sunlight and sea fog, system failures, and O&M logistics. Among the different aspects, limited visibility is shown to be highly relevant with a reduction of up to 60% in accessibility. The study assesses accessibility in five different locations across Europe. On the one hand, accessibility is shown to be less sensitive to long-term resource variations with a reduction of 5% in the last six decades. On the other hand, accessibility is overall shown to be inversely proportional to the energy potential, meaning that as the energy potential increases, accessibility is reduced, increasing downtime, reducing the energy generation and increasing the cost of energy. As a consequence, site selection should combine the energy potential and accessibility assessments, which is enabled by the technology-informed metric presented here.
A Phylogeographic Description of Histoplasma capsulatum in the United States
Authors: Bagal Ujwal R. , Gade Lalitha , Benedict Kaitlin , Howell Victoria , Christophe Natalie , Gibbons-Burgener Suzanne , Hallyburton Sara , Ireland Malia , McCracken Stephanie , Metobo Alison Keyser , Signs Kimberly , Warren Kimberly A. , Litvintseva Anastasia P. , Chow Nancy A.
Published: August 2023

Histoplasmosis is one of the most under-diagnosed and under-reported endemic mycoses in the United States. Histoplasma capsulatum is the causative agent of this disease. To date, molecular epidemiologic studies detailing the phylogeographic structure of H. capsulatum in the United States have been limited. We conducted genomic sequencing using isolates from histoplasmosis cases reported in the United States. We identified North American Clade 2 (NAm2) as the most prevalent clade in the country. Despite high intra-clade diversity, isolates from Minnesota and Michigan cases were predominately clustered by state. Future work incorporating environmental sampling and veterinary surveillance may further elucidate the molecular epidemiology of H. capsulatum in the United States and how genomic sequencing can be applied to the surveillance and outbreak investigation of histoplasmosis.
Nanoparticle-Based Treatment in Glioblastoma
Authors: Roque Diogo , Cruz Nuno , Ferreira Hugo Alexandre , Reis Catarina Pinto , Matela Nuno , Herculano-Carvalho Manuel , Cascão Rita , Faria Claudia C.
Published: August 2023

Glioblastoma (GB) is a malignant glioma associated with a mean overall survival of 12 to 18 months, even with optimal treatment, due to its high relapse rate and treatment resistance. The standardized first-line treatment consists of surgery, which allows for diagnosis and cytoreduction, followed by stereotactic fractionated radiotherapy and chemotherapy. Treatment failure can result from the poor passage of drugs through the blood–brain barrier (BBB). The development of novel and more effective therapeutic approaches is paramount to increasing the life expectancy of GB patients. Nanoparticle-based treatments include epitopes that are designed to interact with specialized transport systems, ultimately allowing the crossing of the BBB, increasing therapeutic efficacy, and reducing systemic toxicity and drug degradation. Polymeric nanoparticles have shown promising results in terms of precisely directing drugs to the brain with minimal systemic side effects. Various methods of drug delivery that pass through the BBB, such as the stereotactic injection of nanoparticles, are being actively tested in vitro and in vivo in animal models. A significant variety of pre-clinical studies with polymeric nanoparticles for the treatment of GB are being conducted, with only a few nanoparticle-based drug delivery systems to date having entered clinical trials. Pre-clinical studies are key to testing the safety and efficacy of these novel anticancer therapies and will hopefully facilitate the testing of the clinical validity of this promising treatment method. Here we review the recent literature concerning the most frequently reported types of nanoparticles for the treatment of GB.
Proposal for Perioperative Pharmacological Protocol for the Reduction in Early Complications in Orthorhinoseptoplasty: Five Years of Experience
Authors: Nocini Riccardo , Arietti Valerio , Barausse Eleonora , Torroni Lorena , Trotolo Alessandro , Sanna Giangiacomo
Published: August 2023

Septorhinoplasty is a crucial intervention in functional and aesthetic facial surgery. Although rare and usually manageable, complications could lead to disfiguring consequences. There is no universal protocol for perioperative management in the literature. The aim of this article is to analyze the surgical complications in patients who underwent open rhinoseptoplasty and were treated in the perioperative period with the standardized protocol used in our department, in order to propose it as a standardized protocol for a more global application. Methods: The patients included underwent rhinoplasty between 2017 and 2022 and were managed with the same treatment protocol. Perioperative and intraoperative data, as well as possible complications, were collected. Results: A total of 129 patients were included, 73% of which reported either mild or no complications. Abnormal scar healing was the most frequent complaint (9%), followed by edema (6.2%), nasal dyspnea (3.9%), infection (2.3%), and bleeding (2.3%). No severe complications were reported. Conclusions: Our protocol appears to be effective in minimizing complications such as infection and bleeding, although it is very difficult to compare the results with the literature.
A Novel Technique for Autograft Preparation Using Patient-Specific Instrumentation (PSI) Assistance in Total Hip Arthroplasty in Developmental Dysplasia of Hip (DDH)
Authors: Lin Chun-Ru , Chou Hsuan , Luo Chu-An , Chang Shu-Hao
Published: August 2023

Due to the change in the structure of the proximal femur and acetabulum in patients with developmental dysplasia of the hip, total hip arthroplasty (THA) was difficult to perform for surgeons. To elevate the acetabular coverage rate, we developed a technique in the use of a patient-specific instrumentation (PSI) graft in patients with developmental dysplasia of hip (DDH) undergoing surgery. This study aims to evaluate the peri-operative outcomes of THA with PSI graft in patients with DDH. This study recruited 6 patients suffering from Crowe I DDH with secondary Grade IV osteoarthritis. All the patients underwent THA with PSI graft performed by a well-experienced surgeon. Perioperative outcomes included surgical procedures, blood loss during operation, the volume of blood transfusion, length of hospitalization, complications, and the mean difference in hemoglobin levels before and after surgery. All the outcomes analyzed were assessed by mean and standard deviation. The average duration of the surgical procedure was found to be 221.17 min, with an SD of 19.65 min. The mean blood loss during the operation was 733.33 mL, with an SD of 355.90 mL. The mean length of hospital stay was calculated to be 6 days, with an SD of 0.89 days. Furthermore, the mean difference between the pre- and postoperative hemoglobin levels was 2.15, with an SD of 0.99. A total of three patients received 2 units of leukocyte-poor red blood cells (LPR) as an accepted blood transfusion. There were no reported complications observed during the admission and one month after the operation. This study reported the peri-operative outcomes in the patients with DDH who underwent THA with PSI graft. We found that THA with PSI graft would provide a safe procedure without significant complications. We assumed that the PSI graft in THA may increase the coverage rate of the acetabulum, which may increase the graft union rates. Further cohort studies and randomized controlled trials were needed to confirm our findings.
Interplay between CSR and the Digitalisation of Bulgarian Financial Enterprises: HRM Approach and Pandemic Evidence
Authors: Zahariev Andrey , Ivanova Petya , Zaharieva Galina , Slaveva Krasimira , Mihaylova Margarita , Todorova Tanya
Published: August 2023

The study presents the economic, managerial, and societal perspectives on corporate social responsibility (CSR) as a basis for adding value to enterprises. It investigates the interplay between the digitalisation of activities and the management of Bulgarian financial enterprises, with a focus on HRM and CSR initiatives in a pandemic situation. The study tests the hypothesis that, in pandemic conditions, the CSR of Bulgarian financial enterprises is positively correlated with the digitalisation of general and human resource management. To assess the level of engagement of financial enterprises with CSR causes during the pandemic, the study employs a methodology comprising descriptive statistics and ordinal regression. The main conclusion, based on a nationally representative survey of Bulgarian financial enterprises, is that banks and insurers that heavily invest in digitalisation have demonstrated a higher level of commitment to CSR causes during the COVID-19 pandemic, while conservative and less digitally advanced financial enterprises have had limited CSR activity. By adopting fintech and insurtech solutions directed towards societal needs, market demands, and customer satisfaction, financial enterprises increase their efficiency. Our analysis confirms the interplay between the digitalisation of financial enterprises and support for CSR causes.
Mapping and Analyses of Land Subsidence in Hengshui, China, Based on InSAR Observations
Authors: Li Man , Ge Daqing , Guo Xiaofang , Zhang Ling , Liu Bin , Wang Yan , Wu Qiong , Wan Xiangxing , Wang Yu
Published: August 2023

In this paper, we use interferometric synthetic aperture radar (InSAR) annual and time-series analysis of RADARSAT-2 SAR data, spanning from September 2011 to October 2022, to study the temporal–spatial characteristics of land subsidence in Hengshui, North China Plain. The data reveal two large-scale subsidence areas in Hengshui, individually located to the north of Hengshui city around the Hutuo River and to the east or south along the Fuyang, Suolu and Qingliang Rivers. The fastest subsidence arises after 2017, with the maximum rate exceeding 11 cm/year. We correlate the observed subsidence with the central table variation of groundwater depression, groundwater table variation of three confined aquifers, hydraulic head declines of three confined aquifers and the time-dependent total hydraulic head variation. We find a spatial consistency between land subsidence and groundwater depression or hydraulic head declines of three confined aquifers, and subsidence displacement and total hydraulic heads both manifest clear seasonal variability. This suggests that the subsidence is primarily caused by groundwater extraction for agricultural use. We also observe that the subsidence rates in Hengshui did not decrease but rather increased when the groundwater table significantly rose after September 2019. It is very likely that as a result of the occurrence of thick and widespread continuity of clay layers with high compressibility in the Quaternary deposit of Hengshui, a new preconsolidation head could be generated due to groundwater table drop, leading to the effective hydraulic head still existing in the aquitards even if the groundwater table rises in the aquifer systems.
How Does Land Monopoly Reduce Consumption Levels? Evidence from China
Authors: Cheng Jian , Zhao Jiangmeng
Published: August 2023

Understanding the intrinsic relationship between land monopoly and a low consumption rate is of great significance for optimizing the national economic structure and reforming the land system. However, existing studies of low consumption ignore the role of the land system. This study, therefore, theoretically analyzed how a monopolistic land supply system inhibits consumption and empirically tested the causal and influencing mechanisms using the mediated effects model and provincial panel data from 2000 to 2017 in China. The results are as follows: (1) land monopoly significantly reduces the final consumption rate; the results remain robust under different model settings. (2) A heterogeneity analysis indicated that the negative effect of land monopoly on consumption is greater in the central and western regions than in the eastern regions; economic catch-up and government intervention increase such harm as well. (3) Under the land monopoly system, most land income flows to the public sector and urban areas, reducing the share of private sector income and expanding the urban–rural income gap, thus limiting private consumption and total urban–rural consumption. (4) During the 2000-2019 period, the expansion of monopolistic land transfers caused an additional 1.98 percentage points of decline in the final consumption rate, contributing 23.41% of the decline in the final consumption rate. Our findings provide new insights into the causes of low consumption and suggest that economic rebalancing can be achieved by breaking land monopolies through land supply-side reforms and land marketization reforms.
Country Perspectives on Hay-Making Landscapes as Part of the European Agricultural Heritage
Authors: Kruse Alexandra , Špulerova Jana , Centeri Csaba , Eiter Sebastian , Ferrario Viviana , Jurgens Suzan , Kladnik Drago , Kučera Zdeněk , Marusca Teodor , Neculai Dragomir , Renes Hans , Sickel Hanne , Sigura Maurizia , Slámová Martina , Stensgaard Kari , Strasser Peter
Published: August 2023

This paper provides an overview of traditional hay-making structures and the related agricultural landscapes in Europe. The information was collected using a standardised questionnaire that was completed by experts from different countries. What all countries had in common was that hay production with its corresponding structures was widespread. However, the scope and importance differed among the countries today. We found differences in type and extent, in degree of awareness, and in the cultural meaning of hay-making structures. The differences were connected with built structures, as well as with other tangible and intangible aspects of cultural heritage. The distribution of the broad variety of hay-making-related structures, especially semipermanent ones, has changed throughout history, as well as the hay-making techniques, as a result of agrarian specialisation, land reclamation, and consolidation. Today, in some countries, the relevance of hay-making was mainly connected to horse keeping and landscape management (like in Germany and Hungary), while in others (like Slovakia and Slovenia), it was still predominantly used for cattle and sheep.
I Don’t Think You like Me: Examining Metaperceptions of Interpersonal Liking in Second Language Academic Interaction
Authors: Trofimovich Pavel , Lindberg Rachael , Bodea Anamaria , Le Thao-Nguyen Nina , Zheng Chaoqun , McDonough Kim
Published: August 2023

People often think about how they are perceived by others, but their perceptions (described as metaperceptions) are frequently off-target. Speakers communicating in their first language demonstrate a robust phenomenon, called the liking gap, where they consistently underestimate how much they are liked by their interlocutors. We extended this research to second language (L2) speakers to determine whether they demonstrate a similar negative bias and if it predicts willingness to engage in future interactions. We paired 76 English L2 university students with a previously unacquainted student to carry out a 10 min academic discussion task in English. After the conversation, students rated each other’s interpersonal liking, speaking skill, and interactional behavior, provided their metaperceptions for their partner’s ratings of the same dimensions, and assessed their willingness to engage in future interaction. We found a reliable interpersonal liking gap for all speakers, along with speaking skill and interaction behavior gaps for female speakers only. Only the female speakers (irrespective of their partner’s gender) seemed to factor metaperceptions into their willingness to engage in future communication. We discuss the implications of these initial findings and call for further work into the role of metaperception in L2 communication.
Aspectual se and Telicity in Heritage Spanish Bilinguals: The Effects of Lexical Access, Dominance, Age of Acquisition, and Patterns of Language Use
Authors: Martínez Vera Gabriel , López Otero Julio César , Sokolova Marina Y. , Cleveland Adam , Marshall Megan Tzeitel , Sánchez Liliana
Published: August 2023

While differences in the production and acceptability of aspectual inflectional morphology between Spanish–English heritage and monolingually raised speakers of Spanish have been argued to support incomplete acquisition approaches to heritage language acquisition, other approaches have argued that differences in access (e.g., lexical access) to representations for receptive and productive purposes are at the core of some of the unique characteristics of heritage language data. We investigate these issues by focusing on the effects of lexical access, dominance, age of acquisition and patterns of language use in heritage Spanish–English bilinguals. We study aspectual se in Spanish, which yields telic interpretations, in expressions such as María se comió la manzana ‘María ate the apple (completely)’ and Maria ate the apple (where completion may not be reached). Our results indicate that se generates telic interpretations for the heritage and monolingually raised group with no group effect. Heritage speakers showed no English effects in terms of lexical access, age of acquisition, patterns of language use or dominance. This suggests that the heritage group did not differ from their monolingually raised counterparts and showed no evidence of incomplete acquisition of telicity.
Unmasking the Hidden Danger: A Decade-Long Systematic Review of Case–Control Studies on Single Occupational Risks and Prostate Cancer
Authors: Ledda Caterina , Bracci Massimo , Spadafora Alba , Motta Giuseppe , Smecca Giuseppe , Catelan Dolores , Rapisarda Venerando
Published: August 2023

The present systematic review addresses the influence of occupational exposures on prostate cancer risk. Eleven studies were analyzed for a range of occupational exposures, including but not limited to firefighting, physical activity, night shift work, chemical exposure, and solar ultraviolet radiation. The results of the review reveal that firefighters exposed to harmful substances, individuals engaged in physically strenuous work, and workers with chronic night shift routines showed an increased likelihood of developing prostate cancer. Moreover, the review identified an increased risk associated with exposure to certain chemicals, including alkylphenolic compounds and benzene-related substances. The evidence underscores the importance of considering the cumulative effect of multiple risk factors in a comprehensive risk assessment. However, the conclusions indicate the necessity for further research to deepen these relationships and develop more effective strategies for the prevention of prostate cancer.
Quantitative Anatomical Studies in Neurosurgery: A Systematic and Critical Review of Research Methods
Authors: Agosti Edoardo , De Maria Lucio , Mattogno Pier Paolo , Della Pepa Giuseppe Maria , D’Onofrio Ginevra Federica , Fiorindi Alessandro , Lauretti Liverana , Olivi Alessandro , Fontanella Marco Maria , Doglietto Francesco
Published: August 2023

Background: The anatomy laboratory can provide the ideal setting for the preclinical phase of neurosurgical research. Our purpose is to comprehensively and critically review the preclinical anatomical quantification methods used in cranial neurosurgery. Methods: A systematic review was conducted following the PRISMA guidelines. The PubMed, Ovid MEDLINE, and Ovid EMBASE databases were searched, yielding 1667 papers. A statistical analysis was performed using R. Results: The included studies were published from 1996 to 2023. The risk of bias assessment indicated high-quality studies. Target exposure was the most studied feature (81.7%), mainly with area quantification (64.9%). The surgical corridor was quantified in 60.9% of studies, more commonly with the quantification of the angle of view (60%). Neuronavigation-based methods benefit from quantifying the surgical pyramid features that define a cranial neurosurgical approach and allowing post-dissection data analyses. Direct measurements might diminish the error that is inherent to navigation methods and are useful to collect a small amount of data. Conclusion: Quantifying neurosurgical approaches in the anatomy laboratory provides an objective assessment of the surgical corridor and target exposure. There is currently limited comparability among quantitative neurosurgical anatomy studies; sharing common research methods will provide comparable data that might also be investigated with artificial intelligence methods.
Automated Electrodermal Activity and Facial Expression Analysis for Continuous Pain Intensity Monitoring on the X-ITE Pain Database
Authors: Othman Ehsan , Werner Philipp , Saxen Frerk , Al-Hamadi Ayoub , Gruss Sascha , Walter Steffen
Published: August 2023

This study focuses on improving healthcare quality by introducing an automated system that continuously monitors patient pain intensity. The system analyzes the Electrodermal Activity (EDA) sensor modality modality, compares the results obtained from both EDA and facial expressions modalities, and late fuses EDA and facial expressions modalities. This work extends our previous studies of pain intensity monitoring via an expanded analysis of the two informative methods. The EDA sensor modality and facial expression analysis play a prominent role in pain recognition; the extracted features reflect the patient’s responses to different pain levels. Three different approaches were applied: Random Forest (RF) baseline methods, Long-Short Term Memory Network (LSTM), and LSTM with the sample-weighting method (LSTM-SW). Evaluation metrics included Micro average F1-score for classification and Mean Squared Error (MSE) and intraclass correlation coefficient (ICC [3, 1]) for both classification and regression. The results highlight the effectiveness of late fusion for EDA and facial expressions, particularly in almost balanced datasets (Micro average F1-score around 61%, ICC about 0.35). EDA regression models, particularly LSTM and LSTM-SW, showed superiority in imbalanced datasets and outperformed guessing (where the majority of votes indicate no pain) and baseline methods (RF indicates Random Forest classifier (RFc) and Random Forest regression (RFr)). In conclusion, by integrating both modalities or utilizing EDA, they can provide medical centers with reliable and valuable insights into patients’ pain experiences and responses.