bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Corporate Social Responsibility on Competitive Advantage: A Case of Newmont Ghana Limited
Authors: Adjei William Ohene
Published: September 2021

Corporate Social Responsibility has taken part in the operations of businesses, but there is a need for research on why CSR is and how advantageous it is for a firm in a competitive market. The paper investigated the use of CSR as a stronghold for firms in a competitive environment using Newmont Ghana Limited as a case study. The study further seeks to identify the impact of Newmont Ghana’s CSR activities and its impact on both the firm’s output and reputational image. These objectives are explored through the evaluation of the effect of Newmont Ghana’s CSR activities. Using a purposive and convenient sampling method, 120 questionnaires, both open and close-ended questions, were distributed to the employees of Newmont Ghana across all levels. The questionnaires were collected and analyzed. The outcome showed that corporate social responsibility gives Newmont Ghana an advantage in positioning and diminishing of competitive attack in the market. Also, the results showed that Newmont Ghana’s CSR activities have a positive impact on its reputation at both the local and national level. Also, CSR activities had a positive impact on its output as it draws in more investors and makes them perform better. The study recommended that firms should integrate CSR into their basic operations and to educate their employees on the firm’s social responsibilities, the general public should be educated on the different duties of all other actors, and the topic should be expanded to include all firms in the mining industry in Ghana and how they benefit from CSR.
Biological sulfate removal with low-cost carbon sources using cold-acclimated bacteria
Authors: Virpiranta Hanna , Taskila Sanna , Leiviskä Tiina , Vepsäläinen Jouko , Rämö Jaakko , Tanskanen Juha
Published: September 2021

The main goal of this study was to develop a cost-efficient biological method for the removal of sulfate from mining effluents in cold conditions. A consortium of cold-tolerant sulfate-reducing bacteria (SRB) was tested at 6 °C regarding the utilization of economically viable, low-cost carbon sources, i.e., whey, conditioned sewage sludge, and peat, in the removal of sulfate from synthetic mining water. Succinate was used as a reference carbon source. Of all the studied low-cost carbon sources, conditioned sewage sludge proved to be the most efficient. Nuclear magnetic resonance (NMR) spectroscopy revealed that sewage sludge contained propionic acid, which proved to be utilizable by SRB under cold conditions. Peat both adsorbed the sulfate and acted as a nutrient source in the sulfate reduction process. When whey was used as a carbon source, only a slight decrease in sulfate concentration was detected. Succinate was found to work in a truly predictable and efficient way as a carbon source in biological sulfate reduction, even at the lowest concentration tested. The use of conditioned sewage sludge increased the bacterial diversity in liquid cultivations significantly. However, the number of SRB was highest in the succinate cultivations.
Justice and sanitation well-being: an analysis of frameworks in the context of slippage, based on findings from Shravasti, Uttar Pradesh, India
Authors: Khare Kopal , Suresh Lavanya
Published: September 2021

Access to safe drinking water and adequate sanitation is considered as a basic human right. Swachh Bharat Mission – Gramin (Rural), launched by the Government of India in 2014, is hailed as an attempt towards that direction. On 2nd October 2019, India was declared free from open defecation, with rural households having full toilet coverage. However, despite Government claims, the existing literature indicates the presence of slippage: where households practice open defecation despite having access to toilets. Equating progress in sanitation interventions with mere toilet provision presents a partial assessment of sanitation. To address the gap, the ‘Sanitation Well-being’ framework, based on Amartya Sen's concept of justice, has been proposed. It identifies slippage as an outcome of various underlying factors across the sanitation life-cycle. The framework provides a lens to analyse existing frameworks and secondary data sets and finds that they do not capture the dynamism inherent in the sector. The efficacy of the framework has been tested in the rural district of Shravasti, Uttar Pradesh, India, through the rapid rural appraisal method. Through our investigation, we found that slippage exists in the field, and that the framework is a feasible instrument to assess sanitation as a comprehensive phenomenon.
Removing free-floating oil from water using cationic polymers/surfactant-modified silica
Authors: Ruksanti Anucha , Janhom Sorapong
Published: September 2021

The purpose of this work was to evaluate the efficiency of oil sorption of silica particles modified by three different types of cationic polymers and a cationic surfactant. Low-molecular-weight polyethyleneimine (LPEI), high-molecular-weight polyethyleneimine (HPEI), polydiallyldimethylammonium chloride (PDM), and cetyltrimethylammonium bromide (CTAB) were used to modify the silica particles and then compared their performances for oil removal. The scanning electron microscope and zeta potential measurements were used to analyze the surface characteristics of unmodified and modified silica particles. Adsorptions of motor oil and palm oil on the modified silica particles have been investigated under various parameters such as the silica particle size, the oil concentration, the polymer/surfactant concentrations, and the pH. The results have shown that the modified silica particles enhanced the oil sorption ability by approximately 10–20 times depending on the size of silica particles, pH, and the type of polymer/surfactant used when compared with the unmodified silica particles. The highest palm oil adsorption values of LPEI-silica, HPEI-silica, PDM-silica, CTAB-silica, and unmodified silica were 2.40, 2.10, 1.95, 1.50, and 0.15 g/gsilica, respectively. Moreover, the oil sorption of the modified silica particles was increased by approximately 30–50% for the smallest-sized silica particles.
Using data mining methods to improve discharge coefficient prediction in Piano Key and Labyrinth weirs
Authors: Majedi-Asl Mahdi , Fuladipanah Mehdi , Arun Venkat , Tripathi Ravi Prakash
Published: September 2021

As a remarkable parameter, the discharge coefficient (Cd) plays an important role in determining weirs' passing capacity. In this research work, the support vector machine (SVM) and the gene expression programming (GEP) algorithms were assessed to predict Cd of piano key weir (PKW), rectangular labyrinth weir (RLW), and trapezoidal labyrinth weir (TLW) with gathered experimental data set. Using dimensional analysis, various combinations of hydraulic and geometric non-dimensional parameters were extracted to perform simulation. The superior model for the SVM and the GEP predictor for PKW, RLW, and TLW included , and respectively. The results showed that both algorithms are potential in predicting discharge coefficient, but the coefficient of determination (RMSE, R2, Cd(DDR)max) illustrated the superiority of the GEP performance over the SVM. The results of the sensitivity analysis determined the highest effective parameters for PKW, RLW, and TLW in predicting discharge coefficients are , , and Fr respectively.
Investigating the role of the morphology of the Zn-Al LDH on the adsorption of humic acid from aqueous solutions
Authors: Khoshalhan Davoudli Hamid , Saadat Solmaz , Rahsepar Mansour , Azadi Fatemeh
Published: September 2021

Flake Zn-Al layered double hydroxides (FLDHs) and microspheres of LDH (MLDHs) were fabricated with a simple hydrothermal method to investigate the role of the morphology of Zn-Al LDH for humic acid (HA) adsorption from synthetic solutions and natural water. The effect of process variables, i.e. contact time, initial concentration of HA, pH, and competitive ions on the adsorption was investigated. HA removal mechanism was also studied. The two adsorbents exhibited different adsorption behaviors for HA in the presence and absence of background ions, which may be highly correlated with the various adsorption mechanisms involved. Comparison of the HA removal capacity of these two adsorbents implies the superior adsorption capability of FLDH for removal of HA from synthetic solutions (9.5 mg/g), while the adsorption capacity of MLDH was higher for natural organic matters present in natural water samples containing co-existing ions (8.9 mg/g). The pseudo-second-order kinetics model and Longmuir isotherm model could adequately interpret the HA adsorption process for the studied adsorbents. Both LDHs exhibited good regeneration and recycling abilities.
Cultura y literatura en los cuentos de Gabriel García Márquez
Authors: Müller Gesine , Navia Velasco Carmiña , Olaciregui Julio , Rey Sinning Édgar , Toro Hernán , Moreno Blanco Juan
Published: September 2021

Cultura y literatura en los cuentos de Gabriel García Márquez reúne seis ensayos sobre diferentes aspectos del género en que se reveló la genial escritura del nobel colombiano. Temas como la representación del afrocolombiano y la mujer, el trasfondo de la cultura magdalenense en las tramas narradas, la influencia de François Rabelais y la relación entre la oniromancia garciamarquiana y la amerindia son complementados con una novedosa clave de lectura que nos invita a reabrir Doce cuentos peregrinos para descubrir en ese libro la novela que no habíamos visto. Si bien alguna vez el autor dijo que escribía cuentos “para que no se me enfriara la mano”, la lectura de estos ensayos confirmará que la narrativa breve garciamarquiana no es para nada ensayo a pequeña escala de una escritura apurada y experimental. Todo lo contrario: su estudio detenido demuestra, si fuera necesario, que sus cuentos son piezas imprescindibles de la invención literaria de un país.
PERFIL DE MORTALIDADE MATERNA NA ÚLTIMA DÉCADA (2010 – 2019) NO ESTADO DA BAHIA
Authors: Souto Figueiredo Nepomuceno Ana Flávia , Souto Figueiredo Mariana , Santos de Jesus Veríssimo , Oliveira dos Santos Liz
Published: September 2021

Introdução: A mortalidade materna é um problema de saúde pública com elevada prevalência e que pode ser, na maioria dos casos, prevenida. As últimas décadas mostraram decréscimo nos índices, no entanto, nota-se que esse problema afeta principalmente regiões com maior vulnerabilidade social, dentre as quais destaca-se o nordeste brasileiro onde encontra-se o estado da Bahia. Objetivo: Analisar o perfil de mortalidade materna na última década no estado da Bahia. Metodologia: Trata-se de um estudo do tipo epidemiológico, transversal, retrospectivo e descritivo, tendo como base a análise secundária de informações disponíveis no Sistema de Informação sobre mortalidade (SIM) no período correspondente a 2010 a 2019 no estado da Bahia, Brasil. Resultados: No período estudado segundo o SIM, foram computados um total de 1313 óbitos maternos no estado da Bahia. A maioria das acometidas apresentava faixa etária de 30 a 39 anos (44,35%), com maior prevalência de pessoas não brancas (81,11%). Quanto à causa da morte, o estudo obteve predomínio de mortes por causas diretas (67,21%) que ocorreram de modo majoritário em ambiente hospitalar (90,17%). Conclusões: Observa-se por meio do presente estudo que a mortalidade materna na Bahia constitui-se como um importante agravo em saúde, o que demanda a elaboração de um conjunto de medidas a fim de garantir segurança às gestantes e puérperas do estado.

Palavras-Chave: Gravidez, Mortalidade Materna, Morte, Saúde da Mulher.
FATORES ASSOCIADOS AO NÃO USO DA PRÓTESE TOTAL INFERIOR E SEU IMPACTO EM IDOSOS BRASILEIROS
Authors: Silva de Miranda Ana Beatriz , Moreira Lima Camila , César Brigolini de Faria Júlio , De Pedro Netto Mendonça Beatriz , De Castro Braga Luciana , Pessôa Pereira Leite Fabíola , Melo Laércio Almeida de
Published: September 2021

Introdução: Grande parte dos idosos caracteriza a reabilitação com prótese total como satisfatória. Entretanto, alguns se mostram insatisfeitos devido a dificuldades com a adaptação, principalmente em relação a prótese total mandibular. Objetivo: Identificar a prevalência e os fatores associados ao não uso da prótese total inferior em idosos. Ademais, verificou-se o impacto do não uso dessa prótese na autopercepção de saúde bucal e na dificuldade de se alimentar. Método: Trata-se de um estudo de base populacional e transversal. Para a sua realização, foi utilizado a base de dados da última Pesquisa Nacional de Saúde realizada no Brasil. Inicialmente, o teste Qui-quadrado foi usado para a análise dos dados. Em seguida, uma análise multivariada do tipo regressão múltipla de Poisson foi realizada para o ajuste das razões de prevalência. Resultados:Participaram 4.582 idosos brasileiros, dos quais 27,1% não faziam uso da prótese total inferior. O não uso da prótese esteve associada aos idosos mais velhos (p=0,001), aos sem instrução (p=0,001), aos que não possuem plano de saúde (p=0,019), aos que fumam (p=0,012) e aos que não realizavam higiene bucal todos os dias (p<0,001). O não uso da prótese total inferior impactou em uma pior autopercepção de saúde bucal (p=0,001) e em maiores dificuldades de se alimentar (p<0,001). Conclusões: O não uso de prótese total inferior está associado a piores condições socioeconômicas e a um pior estilo de vida, fortemente ligado ao ato de fumar. Ademais, o não uso da prótese impacta negativamente na autopercepção de saúde bucal e na alimentação.
materialidade simondoniana e a questão da informação
Authors: Mostafa Solange Puntel , Amorim Igor Soares
Published: September 2021

A noção de informação cristalizou-se na área sob uma perspectiva da Teoria Matemática da Informação, sob o enfoque da comunicação, todavia, essa não é a única semântica possível. Gilbert Simondon utiliza o conceito de informação como elemento envolvido no processo de individuação. Em diálogo com a filosofia de Deleuze e as contribuições do pesquisador Faucher este ensaio explora a ontologia de Simondon a fim que recolocar o conceito de informação à Ciência da Informação. Para Simondon não há indivíduo físico, biológico, psíquico ou social sem informação. A informação implica o devir da e na matéria. Sob tal fundamentação, a Ciência da Informação realiza-se no ciclo virtual-intensivo-atual enquanto segue a materialidade que devém na medida em que se informa e se individualiza. À Ciência da Informação é aberta a possibilidade de pensar a informação enquanto força intensiva sobre um plano imanente.
Mediação via representação temática da informação
Authors: Junior Gerson Moreira Ramos , Gerlin Meri Nadia Marques
Published: September 2021

Objetivo: O presente artigo visa apresentar o processo de Representação Temática da Informação como via mediadora da informação. Intenta-se demonstrar confluências entre a pragmática biblioteconômica e os conceitos que fundamentam a Teoria do Agir Comunicativo, numa perspectiva de reorientação das ações de mediação da informação a partir da ação comunicativa orientada para o consenso linguístico para a superação da colonização do mundo da vida.
Método: Construímos esse caminho por meio de uma pesquisa bibliográfica, buscando em bases de dados da área da Ciência da Informação produções que discorrem sobre tais conceitos, aproximando as discussões sobre representação temática, enquanto elemento de mediação da informação, e a referencialidade teórica habermasiana como possibilidade para a construção de uma abordagem crítica que possibilite aos indivíduos interagirem com a informação, por um processo mediador da informação reorientado por uma razão comunicativa, instada num consenso linguístico aceito por uma comunidade de usuários.
Resultado: Apresentamos a representação temática da informação como via pela qual se perfaz a mediação da informação, associando o processo técnico da representação temática da informação à Teoria do Agir Comunicativo. Vislumbra-se, desta maneira, propor uma mediação da informação que busque o consenso linguístico e a interação, via agir comunicativo, em oposição à razão instrumentalizada pelo capital, reorientando as ações para uma tomada de consciência que leve os atores envolvidos nos processos informativos à superação da visão hegemônica do capital, por meio do uso da razão comunicativa, a partir da qual o consenso estabelecesse por uma linguagem que visa o entendimento comum no ambiente sistêmico das bibliotecas.
The Antioxidant Activity of Phenolic Compounds Isolated from the Bark
of Ryukyu Pine Trees (Pinus luchuensis Mayr.)
Authors: Takashi Hanagasaki , Shoei Teruya
Published: September 2021

Background:

Considering that many foreign tourists visit Okinawa, Japan, to purchase
cosmetic products, there is an urgent need to create cosmetic products native to Okinawa. As the
Ryukyu pine tree, which is endemic to Okinawa, has been used as a source of wood, investigating
the possible use of its bark is recommended. Using this natural resource from Okinawa would aid
in promoting the products of Okinawa’s unique brands. As a result, this study was designed to isolate
useful materials for cosmetic production. Therefore, fractionation was conducted based on a
few types of chromatographies, after which the extracted product of the Ryukyu pine tree (Pinus
luchuensis Mayr.) bark was analyzed, and its polyphenol contents were compared.

Methods:

Bark of the Ryukyu pine tree cultivated in the northern mountainous region of the Okinawa
Main Island was used for ASE extraction using ultrapure water at 130°C. DIAION HP20
with methanol and two HPLC fractionation types were subsequently used for phenolic compound
isolation.

Results:

ASE extraction and HP20 and HPLC fractionations resulted in an isolation of several compounds:
threo-1,2-bis-(4-hydroxy-3-methoxyphenyl)-propane-1,3-diol (compound 1; 0.03% w/w
of an ASE extract), erythro-1,2-bis-(4-hydroxy-3-methoxyphenyl)-propane-1,3-diol (compound 2;
0.03% w/w of an ASE extract), catechin (0.11% w/w of an ASE extract), and vanillin (0.31% w/w
of an ASE extract). In addition, the value of its antioxidant activity determined by the DPPH (2,2-
diphenyl-1-picrylhydrazyl) radical-scavenging capacity assay was 3.3 mmol-trolox eq./g, 2.6
mmol-trolox eq./g, 9.7 mmol-trolox eq./g and 0.7 mmol-trolox eq./g for compound 1, compound 2,
catechin, and vanillic acid, respectively.

Conclusion:

These phenolic compounds possess whitening and anti-aging potentials. Therefore,
the Ryukyu pine tree bark would be a useful raw material source for cosmetic production.
Serial Extraction Technique of Rich Antibacterial Compounds in Sargassum cristaefolium Using Different Solvents and Testing their Activity
Authors: Susilo Bambang , Rohim Abd. , Wahyu Midia Lestari
Published: September 2021

Background:

Sargassum cristaefolium, as one of the brown seaweeds locally found in
Indonesia, is extracted using the serial technique employing different solvents.

Methods:

S. cristaefolium powder (50 mesh) was extracted with three different solvents, including
hexane, ethyl acetate, and methanol. S. cristaefolium powder residue was dried prior to serial re-extraction
using different solvents. Three serial extracts were obtained and named as 1-stage extract,
2-stage extract, and 3-stage extract. Besides, a single-step extract (i.e., extraction using only
methanol) was produced to be compared with three serial extracts in antibacterial activity tests (against
E. coli and S. aureus). The three serial extracts were detected for their antibacterial compounds
using GC-MS, LC-HRMS, and FT-IR.

Results:

The 3-stage extract exhibited the highest extraction yield. On S. aureus, the inhibition
zone in all extracts was not significantly different. On E.coli, the highest inhibition zone
(5.42±0.14 mm) was of the 3-stage extract; indeed, it was higher than both antibiotic and a single-
step extract. Antibacterial compounds, such as phenol, 9-Tricosene(Z)-, palmitic acid, and
oleamide, were present in all extracts. Other antibacterial compound types, both the 1-stage and 2-stage
extracts, contained 7 types, whilst the 3-stage extract contained the most types (11 types). Particularly,
hexyl cinnamic aldehyde, betaine and several cinnamic aldehyde groups were detected only
in the 3-stage extract comprising the dominant area. The carboxylic acid groups were detected in
all extracts to confirm the fatty acid structure.

Conclusions:

The serial extraction technique could produce the 3-stage extract which exhibited the
strongest antibacterial activity and contained the richest antibacterial compounds.
Deep Neck Infections: Decisional Algorithm for Patients with Multiple
Spaces Involvement
Authors: Viola Pasquale , Ricciardiello Filippo , Mazzone Salvatore , Guggino Gianluca , Longo Giuseppe , Napolitano Alberto , Russo Giuseppe , Sequino Giulio , Oliva Flavia , Salomone Pasquale , Perrella Marco , Romano Giovanni Marco , Cinaglia Pietro , Abate Teresa , Gargiulo Maurizio , Pisani Davide , Chiarella Giuseppe
Published: September 2021

Background:

Deep Neck Infections (DNIs) spread along fascial planes and involve
neck spaces. Recently, their incidence has decreased due to the introduction of antibiotics; nevertheless,
complications related to DNIs are often life-threatening.

Objective:

The purpose of this article is focused on the identification of predisposing factors of these
complications, as well as on the development of a reliable therapeutic algorithm.

Method:

Sixty patients with DNIs were enrolled from 2006 to 2019 for a retrospective study. The
exclusion criteria for the present study were cellulitis, small abscesses responding to empiric or specific
antibiotic therapy, or involvement of only one deep neck space. During the analysis, the following
parameters of interest have been evaluated: gender, age, site of origin, pathways of spread,
comorbidities, clinical features, bacteriology data, type of surgical approach required, complications,
duration of hospitalization and mortality rate. On admission, microbial swab analysis was
performed.

Results:

Diabetes Mellitus (DM), Chronic Obstructive Pulmonary Disease (COPD), iron deficiency
anemia and the involvement of multiple spaces have been associated with a significantly higher
risk of developing complications. Most of our patients had polymicrobial infections. All patients
underwent surgical drainage. The complication rate had occurred in 56.6% of patients, while death
in 18.3%.

Conclusion:

DNIs represent a medical and surgical emergency with potentially serious complications;
thus, avoidance of diagnostic delay is mandatory. Our preliminary data suggest the importance
of evaluating the extent of infections because the involvement of multiple spaces requires
timely surgery due to the higher risk of complications and mortality.
Molecular and Metabolomic Investigation of Celecoxib Antiproliferative Activity in
Mono-and Combination Therapy against Breast Cancer Cell Models
Authors: Bardaweel Sanaa K. , Dahabiyeh Lina A. , Akileh Bushra M. , Shalabi Dana D. , AlHiary Afnan K. , Pawling Judy , Dennis James W. , Rahman Anas M. Abdel
Published: September 2021

Background:

Chronic inflammation plays a crucial role in the initiation, promotion, and invasion of tumors,
and thus the antiproliferative effects of numerous anti-inflammatory drugs have been frequently reported in the literature.
Upregulation of the pro-inflammatory enzyme cyclooxygenase-2 (COX-2) has been linked to various human
cancers, including breast cancer.

Objective:

This research aims to investigate the antiproliferative activity of different Non-steroidal anti-inflammatory
drugs (NSAIDs), including COX-2 selective and non-selective agents, against various breast cancer cell lines and to
elucidate possible molecular pathways involved in their activity.

Methods:

The antiproliferative and combined effects of NSAIDs with raloxifene were evaluated by MTT assay. Cell
migration was assessed using a wound-healing assay. The mechanism of cell death was determined using the Annexin
V-FITC/ propidium iodide staining flow cytometry method. A mass spectrometry-based targeted metabolomics approach
was used to profile the metabolomic changes induced in the T47d cells upon drug treatment.

Results:

Our results have demonstrated that celecoxib, a potent and selective COX-2 inhibitor, resulted in significant
antiproliferative activity against all examined breast cancer cell lines with IC50 values of 95.44, 49.50. and 97.70 μM
against MDA-MB-231, T47d, and MCF-7, respectively. Additionally, celecoxib exhibited a synergistic effect against
T47d cells combined with raloxifene, a selective estrogen receptor modulator. Interestingly, celecoxib treatment increased
cell apoptosis and resulted in substantial inhibition of cancer cell migration. In addition, the metabolomic analysis
suggests that celecoxib may have affected metabolites (n = 43) that are involved in several pathways, including the
tricarboxylic acid cycle, amino acids metabolism pathways, and energy production pathways in cancer cells.

Conclusion:

Celecoxib may possess potential therapeutic utility for breast cancer treatment as monotherapy or in combination
therapy. The reported metabolic changes taking place upon celecoxib treatment may shed light on possible
molecular targets mediating the antiproliferative activity of celecoxib in an independent manner of its COX-2 inhibition.
Analysis between Linagliptin and Azithromycin: In vitro and In vivo
Interaction Study
Authors: Sohel Md. Didaruzzaman , Asif Faisal , Mondal Tonmoy Kumar , Sumon Md. Helal Uddin , Kawsar Md. Hassan
Published: September 2021

Background:

Linagliptin is prescribed as a dipeptidyl peptidase-4 (DPP-4) inhibitor.
Azithromycin is specified as an antibiotic that binds with 23s rRNA of the 50s ribosomal subunit,
obstructing the microbial protein synthesis. Our study focuses on the drug-drug interactions of these
drugs.

Objective:

The purpose of the study is to understand the bioavailability and physicochemical approaches
of Linagliptin and Azithromycin interaction mediated through the strength and nature of
the complexation.

Methods:

The in vitro assessment of drug interaction was conducted using Ultraviolet-visible spectroscopy
(UV/VIS), Ultra-Performance Liquid Chromatography (UPLC), Fourier transform infrared
spectroscopy (FT-IR), and Differential scanning calorimetry (DSC), while the Oral Glucose
Tolerance Test (OGTT) was performed for the in vivo assessment of drug interaction in a mouse
model.

Results:

Mild variation in interaction was observed at different pH values at a specific temperature
by Job's and Ardon's equations. In UPLC, the drug mixture assessment showed that the area of Linagliptin
was 2013793, and the area of Azithromycin was 54631 in 50 mg/l. The height of Linagliptin
in the drug mixture was 579234, and that of Azithromycin was 11442. For Azithromycin,
the wavelength of 731.02 cm-1, 993.34 cm-1, 1379.10 cm-1, and 1718.58 cm-1 decreased in the mixture.
Also, for Linagliptin, the wavelength 1363.67 cm-1, 1473.62 cm-1, and 1718.58 cm-1 decreased
in the drug mixture. The melting endotherm was 125.55°C, melting normalized energy was -3.0
W/mg, and 225.75°C with melting normalized energy of -5.5 W/mg of the drug mixture as indicated
by DSC. In the OGTT test, the blood glucose level of Linagliptin decreased in the drug mixture
by 13.58 % and 57.25%.

Conclusion:

Hence, the concomitant administration of Linagliptin and Azithromycin simultaneously
might reduce the therapeutic effect of the drug complex.
An Overview on the Role of miR-451 in Lung Cancer: Diagnosis, Therapy,
and Prognosis
Authors: Soofiyani Saiedeh Razi , Hosseini Kamram , Soleimanian Alireza , Abkhooei Liela , Hoseini Akbar Mohammad , Tarhriz Vahideh , Ghasemnejad Tohid
Published: September 2021

:

MicroRNAs (miRNAs) are highly conserved non-coding RNAs involved in many physiological
processes such as cell proliferation, inhibition, development of apoptosis, differentiation,
suppression of tumorigenicity, and regulation of cell growth. The description of the alterations of
miRNA expression patterns in cancers will be helpful in recognizing biomarkers for early detection
and possible therapeutic intervention in the treatment of cancers. Recent studies have shown that
miR-451 is broadly dysregulated in lung cancer and is a crucial agent in lung tumor progression.
This review summarizes recent advances in the potential role of miR-451 in lung cancer diagnosis,
prognosis, and treatment and provides an insight into the potential use of miR-451 for the development
of advanced therapeutic methods in lung cancer.
An open label single arm prospective clinical study on
Vatagajankusharasa with Pippali Churna and Manjishta
Kwatha as Anupana in Viswachi (cervical spondylosis)
Authors: Gulfam Moh , Muttappa Totad , Bisht Neelam , L Vishnu M , Gopan Yadu
Published: September 2021

Background: Viswachi is one among the 80 Nanatmaja Vata Vyadhi. This disease affects the neck
and upper extremities with the signs and symptoms like Ruk, Stambha, Toda, Bahu Karmakshaya.
Vatagajankusha Rasa is a combination of Vyosha, Bhasmas, Vatsanabha, Karkatasringi, Haritaki etc. It
has Vatakaphahara, Vikasi, Vyavayi, Rasayana etc. properties. It is said to be effective in treating
Visawachi in 7 days if given along with Pippali Churna and Manjishta Kwatha. Aims and Objectives:
To evaluate the efficacy of Vatagajankusha Rasa with Pippali Churna and Manjishta Kwatha as
Anupana in the management of Viswachi (Cervical spondylosis). Methodology: Among 35 registered
patients, 30 completed the course of treatment. They were administered with Vatagajankusha Rasa 1
tablet (125 mg) after food with Anupana 3gm Pippali Churna and 15 ml Manjishta Kwatha twice daily
(morning and evening) for a period of 7 days. Nominal and ordinal data were analysed using non
parametric tests like McNemar and Wilcoxon’s signed rank tests respectively. Result: Assessment
parameters like Ruk, Toda, Sthambha and Bahukarma Kshya. There was statistically significant
improvement in the primary and secondary outcome measures (p less than 0.05 was observed). Conclusion:
Vatagajankusha Rasa with Pippali Churna and Manjishta Kwatha as Anupana is effective in the
management of Viswachi (Cervical spondylosis).
An observational study to evaluate the efficacy of
Agnikarma followed by Bastikarma in Gridhrasi
Authors: T Deepanjali , Goud Kiran M. , DM Shreyas
Published: September 2021

The current lifestyle is the basis for a plethora of diseases. Some are due to the Ahara and some due
to Vihara. Gridhrasi is one of the condition mainly lead down by Viharaja. Among the 80 Vataja
Nanatmja Vyadhi, Gridhrasi is one of the most common condition. It is a Ruja Pradhana Vatavyadhi
i.e., pain is the chief cause for visiting a doctor in most of patient histories, hence it is necessary to
adopt fast management for the same. Gridhrasi starts from Sphik Pradesha and gradually comes down
to Kati, Prista, Uru, Janu, Janga and Pada. Kevala Vataja and Vata Kaphaja are the two clinical
variations in the presentation of Gridhrasi. Snigdha Sweda, Virechana, Basti, Agnikarma and
Siravyadha are the Chikitsa mentioned in the classical literature. In the present study, Snigdha
Agnikarma followed by Erandamoola Niruha Basti has been adopted. Significant changes (p less than 0.01)
were noticed in the parameters of the study.
A Randomized Comparative Clinical Study to evaluate the effect of Bodhi Vruksha Twak Kashaya with Madhu and Guduchi Kashaya in the Management of Vatarakta with special reference to Gouty Arthritis
Authors: Bhavana K. M. , C Umesh , Sajjanar Neelakanta , G Gopala Krishna
Published: September 2021

Background: Vatarakta is a disease which is said to affect the population indulging in sedentary lifestyle. In today’s era the evolution of technology has reached a point where pretty much anything is available at the touch of a button. The lifestyle of today’s population is breeding ground for diseases like Vatarakta. Based on the causes, signs and symptoms, Vatarakta may be correlated to gouty arthritis in contemporary medicine. Gout affects about 2.1 million worldwide. Its prevalence is increasing; moreover it is a potential signal for unrecognized co-morbidities like obesity, diabetes mellitus, hypertension and renal diseases. In India the prevalence of gout is 2-6 per 1000. The purpose of this study is to explore and find out an effective, less expensive, easily available and well accepted drug with minimal or no complications for this dreadful condition. Materials and Methods: 40 patients diagnosed with Vatarakta w.s.r Gouty Arthritis were assigned randomly into 2 groups. Group A, were administered Bodhi Vruksha Twak Kashaya 50ml B.I.D with Madhu and Group B were administered Guduchi Kashaya 50ml B.I.D for a duration of 30 days. Assessment was done on day 0, day 15, day 30, and day 45. Observations and Results: In the present study Group A showed statistical significant results in all the parameters except for Sandhishotha and group B showed statistical significant result in Sandhishoola, Sandhidaha, Sparshasahaishnuta and uric acid levels. Conclusion: Overall result shows patients treated with Guduchi Kashaya showed better results than patients treated with Bodhi Vruksha Twak Kashaya with Madhu in Vatarakta with special reference to Gouty Arthritis.
An effect of Haridra and Laghu Dugdhika on Tamaka
Shwasa
Authors: Sharma R. R.
Published: September 2021

The fast and mechanical life with dust and pollution of today's era has kept the man away from the
normal regimen for sound health which ultimately gives rise to various diseases. The role of medicine
become in effective continuous use of medicines. Even the modern medicine has recognized the
important role but now Ayurvedic medicines has very effective.
Pharmaceutico - Analytical study of Trailokyamohana
Rasa
Authors: Kulkarni Pavan , Deshpande P. R.
Published: September 2021

Herbo-mineral formulations occupies significant seat in Ayurvedic pharmaceutics. Nearly 70%
formulations include combination of one or more metallic/mineral with several herbs which have
supporting role in treating the disease. Trailokyamohana Rasa is one of the herbo- mineral
formulation prepared by the Kupipakwa Rasayana method explained in the context of Prameha. The
present study deals with the preparation and analytical study of Trailokyamohana Rasa, a unique
formulation prepared by Antardhuma method of Kupipakwa Rasayana. The analysis of
Trailokyamohana Rasa showed 8.4pH, 1.36% loss on drying, 68.94% of total ash and 38.56% of acid
insoluble ash. X-RAY Diffraction Study of the sample revealed the peak of mercury which was in HgS
form. Peaks also showed traces of Calcium, Tin and sulphur which was crystalline in nature. AAS
analysis was done which revealed the traces of Calcium 16%, Tin as 7.56%, sulphur as 3.8%,
carbonate as 40.25% and loss on ignition was 49.30% and Hg level showed below 1 ppm. Peaks at
intervals showed the traces of Hg (Mercury), S (Sulphur). Second peaks showed the traces of
Ca(Calcium) and Sn (Tin). Some other components were found such as C (Carbon), O (Oxide), Na
(Sodium), Al (Aluminium), Si (Silicon), P (Phosphorus), Cl (Chlorine), K (Potassium), Fe (Iron), Cu
(Copper).
Rookshana Poorvaka Vamana Karma and Rookshana
Poorvaka Virechana Karma in the management of
Sthoulya vis-a-vis Obesity - Comparative Clinical Study
Authors: Kumar S Jagadesh , DM Shreyas , Goud Kiran M.
Published: September 2021

Obesity with its devastating consequences is a global health problem of this era. Presently Obesity in
India has reached epidemic proportions in the 21st century, with morbid Obesity affecting 5% of the
country’s population. The characteristic features of Obesity have close resemblance with Sthoulya in
Ayurveda. Sthoulya is one among Santharpanottha Vyadhi, one among the Ashta Nindita Purushas,
Kapha Nanatmaja Vyadhi and Dushta Medo Roga. Sthoulya being Bahudoshavasta and Mamsala,
Medhura and Bhuri Sleshma Vyadhi. Hence, considering the condition, a comparative study was
planned to compare the efficacy of Rookshana Poorvaka Vamana and Virechana Karma. The objective
criteria were assessed before and after treatment. The results was statistically highly significant within
the group, at the level of P value less than 0.001. Between the groups, Rookshana Poorvaka Vamana Karma
group showed better results in comparision of mean difference to that of Rookshana Poorvaka
Virechana Karma group.
An observational study on Nidana of Janusandhigata
Vata w.s.r to Knee Osteoarthritis
Authors: Shellgi Vishal Kumar
Published: September 2021

Ayurveda, the holistic life science aims at physical, social and spiritual well-being of an individual. As
age advances Vata Dosha increases in an individual. This increasing Vata triggers and accelerates
Dhatu Kshaya (depletion of tissues) and Bala Kshaya (reduction of strength). Sandhigata Vata is a
commonest disorder, occurs due to Dhatukshya. Vata Dosha plays a main role in the disease. Shoola
is the cardinal feature of this disease, associated with Sandhishotha with Vatapurnadrutisparsha.
Sandhigata Vata manifests when the deranged Vata lodges in joints. If the condition manifests in
Janusandhi, then it is called as Janu Sandhigata Vata. In modern science, Sandhigata Vata is corelated
with osteoarthritis (OA). Osteoarthritis is a chronic disorder of synovial joints in which there is
a progressive softening and disintegration of articular cartilage accompanied by the growth of
osteophytes. So here an effort was made in this study to understand the Nidana of Sandhigata Vata
especially Janu Sandhi w.s.r to osteoarthritis of knee joint in all dimensions.
Role of Sarvanga Udwartana and Takradhara in
Eka-Kushta w.s.r to Psoriasis - Observation Study
Authors: T Deepanjali , Goud Kiran M. , DM Shreyas
Published: September 2021

Eka-Kushta is one among the Kshudra Kushta presenting with Lakshanas like Aswedanam, Mahavastu
and Matsyashakalopama. It is of prime importance due to its chronicity and severity which involves a
larger extent of the body. This is often compared to Psoriasis. Psoriasis is one of the most common
dermatological conditions affecting both males and females upto 2% of world’s population. It is an
immune mediated disease characterized by erythematous, sharply demarcated papules and rounded
plaques covered by silvery micaceous scale which are variably pruritic. Traumatized areas, infections,
stress and medications like beta blockers, anti-malarial drugs may exacerbate psoriasis. Kushta, a
disease of Bahudosha, Bhuridosha and Saptakodravya Sangraha is to be treated by adopting repeated
Antah Parimarjana as well as Bahir Parimarjanachikitsa. The present study was aimed to assess the
efficacy of Bahir Parimarjana Chikitsa in the form Sarvangaudwarthana with Manjistha Choorna,
Triphala Choorna and Takradhara with Musta, Asandi, Amalaki Choorna. This is a clinical study
wherein 20 diagnosed Eka-Kushta patients of either sex were selected. The overall result in the study
revealed that there is statistically significant (p less than 0.001) improvement in patients after the treatment.
Role of Samyoga Viruddha Ahara in Kustha Vyadhi - An Observational Study
Authors: Deshmukh Raosaheb A.
Published: September 2021

Food plays a decisive role in development, sustain, reproduction and termination of life. Through centuries, Food has been recognized as an important factor for human beings, in health and diseased state. Viruddha Ahara is one potent causative factor for several diseases. Consumption of Viruddha Ahara gives rise to various disturbances of mild to violent nature and disease of acute to chronic nature including the eight Maharogas, genetic disturbances and even sometimes causes death of the person. To conduct on observational study to access the role of Samyoga Viruddha Ahara is one of the Nidana for manifestation of Kustha Vyadhi. In the present observational study were selected of total 50 patients was conducted at O.P.D, Patients were screened on the basis of specially prepared questionnaires format. On Observational study majority of patients i.e. 82% of patients were consumed Samyoga Viruddha Ahara majority of patients i.e. 58% were consuming Viruddha Ahara (Samyogaja Viruddha Ahara), 26% were doing Malamutra Vega Dharana, 16% were doing Vyayama after Bhojana and 36% patients were doing Diwaswapna.
Understanding the etiology of Arshas - An Observational Study
Authors: S Nikhil , Markande Geetha B. , Jain Prashanth
Published: September 2021

Lifestyle disorders are becoming the major cause of ill health and disability worldwide. Hemorrhoid is one such disease which makes human life miserable. Hemorrhoids is nothing but the varicosity of blood vessels found inside or around the bottom the rectum and anus. Age group of 45-65yrs, it is estimated that 50-85% of people around the world have hemorrhoids.[1] In India 75% of the population is estimated. Clinical features of hemorrhoid resembles with Arshas. In Ayurveda classics, there are detail information about the Aharaja (Anashana, Adhyashana), Viharaja (Ativyayama, Divaswapna), Manasika (Shoka, Krodha) and Agantujanidanas (Gudakharshana, Vastivibhrama) which are responsible for the manifestation of Arsha. Common symptoms are itching, burning sensation and pain in the region of Guda and finally bleeds.[2] Maintaining the health and providing the health is the main motto of Ayurveda. This ground incorporates usage of different remedies with focusing on Nidana Parivarjana. Thus understanding the Nidana Parivarjana is the prime importance. In this study an effort is done to identify the prime causative factors in deal to Arshas.
A comparative clinical study of the effect of Upanaha Sweda by using Kottamchukkadi Churna and Grihadhumadi Churna in Janusandhigata Vata w.s.r. to Osteoarthritis of Knee Joint
Authors: PK Reshmi , A Sudarshan , Chandran Jeejo
Published: September 2021

As per Ayurveda, Janusandhigata Vata is one among Vatavyadhi and can be compared with Osteoarthritis of Knee Joint in Modern Medicine with respect to the similarity of symptoms. Aims and Objectives: To evaluate and compare the effect of Grihadhumadi and Kottamchukkadi Upanaha in Janusandhigata Vata. Methods: Single blind randomized comparative clinical study allocated into 2 equal groups as A and B. Procedure: In Group A, Grihadhumadi Upanaha Sweda done for 7 days and in Group B, Kottamchukkadi Upanaha Sweda done for 7 days. Patients were examined as per the assessment criteria on 1st day before treatment, 8th day after completion of the treatment and 15th day as part of follow up. Observations and Results: Group A showed statistically highly significant effect in most of the criteria’s like Swelling, Stiffness, Tenderness, Visual Analogue Scale (VAS), Range Of Movements (ROM) and WOMAC INDEX. Group B showed statistically highly significant effect in Pain and Crepitation.
Effect of Phaltrikadi Kwatha in the management of Pandu in Children - An Open Clinical Trial
Authors: Kumar Vikas , Savanur Pankaja P.
Published: September 2021

Background: Pandu (Anemia) is one of the commonest and most prevalent diseases in Pediatric population in India. Drugs available in the market used for treating Anemia (Pandu) have untoward effects like constipation, non-palatability, intolerance, loss of appetite etc. It is today’s need to safely treat the Pandu (Anemia) in children with herbal preparations which are mentioned in many Ayurvedic Classics which are economical and safe. So Phalatrikadi Kwatha a formulation mentioned to be useful in the management of Pandu Roga was used in the present study. Aim and Objectives: Primary: To evaluate the efficacy of Phalatrikadi Kwatha in Pandu in children. Secondary: To evaluate the Efficacy of Phalatrikadi Kwatha in different Prakruti in Pandu in children. Methodology: This study was an interventional open labelled clinical trial and conducted on 30 diagnosed Patients of Pandu for a period of 30 days. Follow up was done on 10th, 20th, 30th days of study on the basis of subjective criteria and Hb% before treatment and after treatment. Results: Symptoms of Anemia and Hb% level were statistically analysed for any change before treatment, after treatment and during the follow up. Statistically significant changes (p less than 0.05) were observed in subjective (Dourbalyata, Aruchi) and objective (Hb%) parameters of Pandu Rogi. No significant difference was observed in different specific Dosha dominant Prakruti. Conclusion: Phalatrikadi Kwatha was found effective in the treatment of Pandu in children, thus showing significant results with respect to symptoms like Dourbalyata, Aruchi and increase in Hb%.
A comparative clinical study to access the role of Basti and Virechana Karma followed by Rasayana in post menopausal Asthikshaya (Osteoporosis)
Authors: Patil Deepa S. , A.S Prashanth
Published: September 2021

Rajonivrutti condition manifests in the end phase of Jarawastha; but its Samprapti begins from the Sandhikala of Madhyamawastha and Jarawastha due to Vatavruddi in womens reaching Rajonivrutti. Postmenopausal Asthikshaya is a disabling disease, which renders women a bedridden life. Here 40 subjects diagnosed with postmenopausal Asthikshaya fulfilling the inclusion criteria were selected for the study and randomly categorized intp two groups as group A and group B each consisting of 20 subjects. Group A received Amapachana with Hinguvachadivati, Yastimadhu Siddha Ksheerabasti administered in Yoga Basti schedule followed by Tritiyatriphala Rasayana. Group B received Amapachana with Hinguvachadivati, Sadhyosnehapana with Amrita Ghrita, Sarvanga Abyanga with Murchita Tilataila followed by Sarvanga Swedana and Sneha Virechana was admistered with Eranda Taila followed by Tritiyatriphala Rasayana was given. Tritiya Triphala Rasayana selected for the present study by adapting all the general principles of prevention and management of Asthikshaya and as it is a well known Rasayana.
A comparative clinical study on the cosmetic approach in Tarunyapidaka vis-a-vis Acne Vulgaris amongst female population through Shodhana Shamana and Lepa
Authors: A Sharanamma , A.S. Prashanth , Chavan S.G.
Published: September 2021

Tarunyapiadaka is one of the Kshudraroga and most common skin disorders. Ayurvedic medicine plays important role in the patients who are in deep depression due to disfiguration of face and Tarunyapidaka in the field of Cosmetiology. In the present study an effort has been made to formulate an effective, economic and simple remedy to help in the total cure and preventing of Tarunyapidaka. In the present study 40 Subjects diagnosed with Tarunyapidaka w.s.r to Acne Vulgaris fulfilling the Inclusion criteria were selected for study and randomly categorized into two groups as Group A and Group B each consisting of 20 subjects from OPD and IPD of department of PG studies in Kayachikitsa department of Ayurveda Mahavidhyalaya, Hubbali have been treated with Amapachana with Guduchi Churna. In group A Sadhyosnehapana with Panchatikta Ghrita. Sarvanga Abhyanga with Elaadi Taila followed by Sarvanga Swedana. And Sneha Virechana was administered with Trivruth Lehya. After Samsarjana Krama, Navaka Kashaya given as a Shamanoushadi along with Manjista with Madhu Lepa. In Group B Sadhyosnehapana with Panchatikta Ghrita. Sarvanga Abhyanga with Elaadi Taila followed by Sarvanga Swedana and Sneha Virechana was administered with Trivruth Lehya. After Samsarjana Krama, Gopanganadi Kashaya given as a Shamanoushadi along with Manjista with Madhu Lepa for 45 days to assess the clinical efficacy of Navaka Kashaya and Gopanganadi Kashaya. Significant changes in Subjective and Objective criteria were observed.