bluuebunny/crossref_metadata_2025 huggingface dataset:
LRP1B affects lung adenocarcinoma immunotherapy efficacy via ferroptosis
Authors: ke zihao , yu tao , zhang qi , chen ying , lu kaihua
Published: July 2023

Background Currently, the clinically used immune biomarkers for non-small cell lung cancer (NSCLC) are programmed death ligand 1 (PD-L1) and tumor mutation burden (TMB). However, they cannot accurately predict the effectiveness of immunotherapy. Identifying appropriate biomarkers that can differentiate between beneficiary groups is imperative. Methods We identified LRP1B as a potential biomarker for immunotherapy by analyzing clinical data, combined with bioinformatics analysis. The effects of LRP1B on ferroptosis were assessed using qRT-PCR, Western blotting, CCK-8 assay, and flow cytometry. The potential mechanism underlying the regulation of ferroptosis by LRP1B was elucidated using qRT-PCR, Western blotting, ChIP, and dual-luciferase reporter gene assays. Results Through the collection and analysis of clinical data, we had established that LRP1B mutation is a highly promising biomarker for immunotherapy. Bioinformatics analysis revealed significant differences in the expression levels of PD-L1 and TMB between patients with LRP1B mutation and wild-type patients in lung adenocarcinoma (LUAD), while in lung squamous cell carcinoma (LUSC), only the level of TMB showed a significant difference. Furthermore, we observed that patients with LRP1B mutation in LUAD had significantly higher levels of tumor-infiltrating lymphocytes (TILs), including CD4+T cells and M1 macrophages, than wild-type patients, whereas in LUSC, no such differences were detected. In addition, we found that patients with LRP1B mutation in LUAD had significantly prolonged progression-free survival (PFS) compared to wild-type patients, but no PFS benefit was observed in patients with LRP1B mutation in LUSC. These findings provided strong evidence that LRP1B mutation was a potential biomarker for immunotherapy in LUAD. Moreover, our in vivo experiments indicated that knockdown of LRP1B enhanced the efficacy of mPD-1, and mechanistic studies revealed that LRP1B regulated the sensitivity of cells to ferroptosis by modulating the expression of SLC7A11 through altering the phosphorylation level of STAT3. Importantly, LRP1B alterations also affected the sensitivity of cells to ferroptosis induced by IFN-γ. Further analysis revealed that LRP1B knockdown promoted immunotherapy in vivo. Conclusions Our results confirmed that LRP1B affected the efficacy of immunotherapy by modulating the sensitivity of NSCLC cells to ferroptosis.
Synergistic interaction of Artemisia cina n-hexanic extract and Tagetes lucida ethyl acetate extract on Haemonchus contortus
Authors: Santiago-Figueroa Itzel , González-Cortázar Manasés , Estrada-Flores Julieta Gertrudis , Cuéllar-Ordaz Jorge Alfredo , López-Arellano Maria Eugenia , González-Reyes Francisco Javier , Olmedo-Juárez Agustín , Piedrahita Rosa Isabel Higuera
Published: July 2023

The present study aimed to analyze the possible synergistic activity among the active extracts from Artemisia cina and Tagetes lucida combinations on the Haemonchus contortus nematode parasite of sheep. The work was carried out in vitro on eggs and infective larvae 3 of H. contortus. Also, the characterization of the extracts was made with HPLC. The results were analyzed with SAS 9.1 apply the anova and Tukey test, and the lethal concentration (LC) LC50 and LC90 were determined with regression analysis employed Proc Probit of SAS 9.1. Additionally, the FT was calculated with LC50 and LC90 to determine the synergistic effect. The results demonstrated high efficacy of the two plants studied on both nematode stages egg and larvae L3, as well as of their combinations in where the best inhibition hatch egg was obtained with 50/50% combination of each plant and the best larvae mortality were obtained with 25% A. cina and 75% T. lucida at 10 mg/ml, additionally this combination showed synergistic effect. In conclusion the two plants are an option as anthelmintic non pharmacological due to high bioactive effect and due to their synergistical response.
Correlations between microbiota-derived metabolites and cervical precancerous lesions in women with HPV
Authors: Shen Su , Zhao Shixian , Shan Jinjun , Ren Qingling
Published: July 2023

High-risk human papillomavirus (HR-HPV) causes cervical squamous intraepithelial lesions and cervical cancer; however, only a small group of people infected with HR-HPV will develop cervical precancerous lesions or cervical cancer. Current studies have shown that an imbalance in the cervicovaginal flora may be one of the factors for persistent HR-HPV infection. Cervicovaginal secretions are easily accessible and may be advantageous tools for diagnosing risks for cervical cancer. Thus, in this pilot study we collected 156 cervicovaginal secretions of women with HPV infection with precancerous cervical lesions to determine whether microflora-derived metabolites present in the secretion can be used for assessing the risk of cervical cancer in patients. We performed 16S rRNA sequencing and metabolomic analyses to identify changes in the cervicovaginal flora and its metabolites in patients with HPV infection with different grades of cervical lesions. We detected 164 common known metabolites in the three groups of samples. There are significant differences in the metabolic patterns of cervical lesion groups with different degrees, and multiple metabolites are significantly related to the vaginal flora. Among them, the content of metabolites such as taurine, guanine, and uric acid are significantly different in patients with persistent HR-HPV infection with different degrees of cervical lesions. Taurine is positively correlated with Weissella, and negatively correlated with Corynebacterium. Related. Which may involve 7 related metabolic pathways. Metabolites such as taurine, guanine, and uric acid are closely related to the activation of the human immune system. Cervical vaginal flora can regulate the synthesis and decomposition of amino acids, purines, and uric acid, and may play a major role in activating inflammation and the immune system. These metabolisms It is worthy of further research to assess the risk of HR-HPV infection progressing to cervical cancer.
The clinical characteristics of non-cystic fibrosis bronchiectasis patients with positive serum tumor markers: a retrospective study
Authors: Wang Xiaoyue , Wang Juan , He Siqi , Li Jing , Chen Xiaoting , Ma Tianyuan , Liu Lu , Zhang Lei , Bu Xiao-ning
Published: July 2023

Background
Serum tumor markers (STM), extensively used for the diagnosis, monitoring and prognostic assessment of tumors, can be increased in some non-malignant lung diseases. To date, there is a paucity of studies regarding the clinical characteristics of non-cystic fibrosis bronchiectasis patients with positive STMs.
Objective
To investigate the clinical characteristics and risk factors of bronchiectasis with one and multiple positive STMs.
Methods
The clinical data of 377 bronchiectasis patients was retrospectively collected from January 2017 to December 2019 from Beijing Chaoyang Hospital. Patients were divided into STM positive and STM negative group. According to the number of the positive STMs, the STM positive group was further subdivided into the single STM positive group and the ≥ 2 STMs positive group. The clinical characteristics are described and compared separately and the multivariate logistic regression analysis model was used to investigate the risk factors regarding the positive STMs.
Results
Patients in the STM positive group were older (P = 0.005), had a longer disease duration (P = 0.026), higher mMRC scores (P = 0.019) and developed higher fever (P = 0.027). Additionally, patients with positive STMs also had lower Albumin/Globulin Ratio (A/G), prealbumin (PAB) (P = 0.016, P = 0.043, respectively) and higher CRP, ESR and Fbg (P = 0.001, P = 0.002 and P < 0.001, respectively). ESR (OR 1.824, 95%CI 1.061–3.137; P = 0.030) and the number of affected lobes (OR 1.388, 95%CI 1.184–1.627; P < 0.001) were independently associated with one and two or more positive STMs in bronchiectasis patients.
Conclusion
The positive STM is associated with a higher inflammation status and severer radiologic manifestations in bronchiectasis patients.
Towards establishing a correlate of protection against shigellosis: assessing immunological endpoints across immune responses to the Shigella sonnei 1790GAHB GMMA investigational vaccine
Authors: Nakakana Usman , Conti Valentino , Rossi Omar , Clarkson Kirsten , Mancini Francesca , Sarakinou Eleanna , Callegaro Andrea , Ferruzzi Pietro , Acquaviva Alessandra , Arora Ashwani , Marchetti Elisa , Necchi Francesca , Frenck Robert , Martin Laura , Kaminski Robert , Podda Audino , Micoli Francesca
Published: July 2023

Shigella spp. are a leading bacterial cause of diarrhea. No widely licensed vaccines are available and there is no generally accepted correlate of protection. We tested a S. sonnei GMMA-based vaccine (1790GAHB) in a phase 2b, placebo-controlled, randomized, controlled human infection model study (NCT03527173) enrolling healthy US adults aged 18–50 years. We report analyses evaluating immune responses to vaccination, with the aim to identify correlates of risk for shigellosis among assessed immunomarkers. We found that 1790GAHB elicited S. sonnei lipopolysaccharide specific α4β7 + IgG and IgA secreting B cells which are likely homing to the gut, indicating the ability to induce a mucosal in addition to a systemic response, despite parenteral delivery. We were unable to establish or confirm threshold levels that predict vaccine efficacy facilitating the evaluation of vaccine candidates. However, serum anti-lipopolysaccharide IgG and bactericidal activity were identified as potential correlates of risk for shigellosis.
Correlation of glomerular mannose-binding lectin deposition with the clinicopathology and prognosis of PLA2R-associated membranous nephropathy
Authors: Pan Yan , Liu Lei , Zhang Jiqiang , Zhao Ruiping , Han Yuzhe , Chen Weidong
Published: July 2023

Mannose-binding lectin (MBL) and autoantibody IgG4 staining against the phospholipase A2 receptor (PLA2R)were correlated. To enquire into the pathogenic effect of MBL in IMN as well as its relevance to clinicopathology and prognosis.Patients with IMN in 2021–2022 at our hospital were divided into positive and negative groups based on glomerular MBL immunofluorescence results and anti-PLA2R antibody characterization, and their clinical, pathological and follow-up data were evaluated.Among 39 patients with IMN, the positive rates of glomerular MBL and IgG4 deposition and serum anti-PLA2R antibodies were 31 (79.5%), 37 (100%) and 26 (70.3%), respectively. There were no notable differences in clinical and pathological features between the MBL-positive and negative groups of patients, but there were differences in IgG4 expression in the renal tissues (p < 0.05). There were no notable differences in MBL deposition between IMN patients grouped qualitatively by blood PLA2R antibodies. Renal tissue MBL was highly expressed (79.5%) and C1q was lowly expressed (15.38%). Kaplan-Meier analysis of clinical remission was similar in both groups. In multivariate COX regression analysis adjusted for sex, age, serum anti-PLA2R antibody concentration and blood pressure, MBL deposition (HR, 0.776; 95% CI, 0.311–1.939; p = 0.587) was not associated with IMN remission in the MBL-negative compared with the positive group.Renal tissue MBL characterization correlates with IgG4 and anti-PLA2R antibodies are involved in the pathogenesis of IMN through the induction of complement activation by the complement agglutinin pathway. No significant clinical, pathological or prognostic differences between patients with positive and negative MBL deposits were found in the study.
Time to Failure Prediction of Rotating Machinery using Dynamic Feature Extraction and Gaussian Process Regression
Authors: Lee Wo Jae , Sutherland John W.
Published: July 2023

Recent advances in sensor technology and computing power allow for the generation/utilization of larger and more diverse sets of data. These developments enable the creation of data-driven models that can support real-time decision making. Such a decision aid can allow for predictive maintenance (PdM) to be undertaken on a much greater scale in manufacturing plants. PdM includes data-driven prognostics and health management (PHM). To enhance the performance of a prognostic model, one key task is to collect high-quality data, and in the past this has often involved using a feature extraction method to get meaningful information from a large noisy dataset. However, such methods may not handle noisy data well or address measurement errors adequately. Consequently, extracted features may not represent a degradation process suitably as a machine approaches a failure or fault. Also, effects of sensor types on the feature extraction and prediction model have not been much explored yet. To overcome this limitation, dynamic feature extraction is proposed to mitigate the effect of noisy statistical features in a monotonic trend by introducing a statistical penalty. Then, the features extracted through the method are used to construct a health indicator (HI). With the available historical HI values, a probabilistic regression model may be used to forecast the time to failure (TTF) of rotating machinery with uncertainty propagation. To validate the proposed method, acceleration data were collected from rotating machinery for several run-to-failure cases. The proposed method is demonstrated to provide excellent forecasts of TTF for both accelerometer types.
Occurrence of Emerging Mycotoxins in Chicken Feed and Eggs from Algeria
Authors: Laouni Chahinez , Hernández-Mesa Maykel , Messai Ahmed , Redouane-Salah Sara , Lara Francisco J. , Gámiz-Gracia Laura , García-Campaña Ana M.
Published: July 2023

Poultry farming has developed into one of Algeria's most productive agricultural indus-tries because of the growing demand for sources of protein among Algerian society. Laying hen feed consists mainly of cereals, which can be contaminated with molds and subsequently with their secondary metabolites known as mycotoxins. These later can pose a serious danger to the produc-tion and quality of eggs in the commercial layer industry. This work focuses on the detection of emerging mycotoxins, mainly enniatins (ENNs) and beauvericin (BEA), in poultry feed and eggs from different locations in Algeria. Two different QuEChERS-based extractions were established to extract ENNs and BEA from chicken feed and eggs. The determination of mycotoxins occurrence was achieved by a UHPLC-MS/MS method using 0.1% (v/v) formic acid in water and MeOH as mobile phase, an ESI interface operating in positive mode and a triple quadrupole mass spectrom-eter operating in MRM for the detection. Matrix-matched calibration curves were carried out for both matrices, obtaining good linearity (R2 > 0.99). The method performance was assessed in terms of extraction recovery (from 87% to 107%), matrix effect (from -47% to -86%), precision (RSD < 15%) and limits of quantitation (≤1.1 µg/kg for feed and ≤ 0.8 µg/kg for eggs). The analysis of 10 chicken feed samples and 35 egg samples showed that ENN B1 was the most common mycotoxin (i.e. found in 9 samples) with contamination levels ranging from 3.6 to 41.5 µg/kg, while BEA was detected only in one sample (12 µg/kg). However, eggs were not found to be contaminated with any my-cotoxin at the detection limit levels. Our findings indicate that the searched mycotoxins are present in traces in feed and absent in eggs. This can be explained by the application of mycotoxins binder. However, this does not put a stop on the conduction of additional research and ultimately setting regulations to prevent the occurrence of emerging mycotoxins.
Identification machine learning-based model of programmed cell-death patterns for investigating the immune microenvironment and prognosis of ovarian cancer patients after surgery and providing therapeutic strategies
Authors: Han Lei , Wang Fei , Chen Weiwei , Zhai Qingliang , Zhang Xianghui , Xu Huishu , Zhang Baolin , Wang Yanlin , An Jiajia , Pan Yitong
Published: July 2023

Background Ovarian cancer (OV) is a highly aggressive and often fatal disease that frequently goes undetected until it has already metastasized. The classic treatment for ovarian cancer involves surgery followed by chemotherapy. However, despite the effectiveness of surgery, relapse is still a common occurrence. Unfortunately, there is currently no ideal predictive model for the progression and drug sensitivity of postoperative ovarian cancer patients. Cell death patterns play an important role in tumor progression and have the potential to be used as indicators of postoperative OV prognosis and drug sensitivity. Materials and methods A total of 12 PCD patterns were employed to construct the model. Bulk transcriptome, single-cell transcriptome, genomics, and clinical information were collected from TCGA-OV, GSE9891, GSE26712, GSE49997 and GSE63885. In addition, single-cell transcriptome data GSE210347 was procured from the Gene Expression Omnibus (GEO) database for subsequent analysis. Results In this study, a programmed cell death index (PCDI) was established using an 8-gene signature with the help of a machine learning algorithm. The PCDI was validated in four independent datasets, and it was found that patients with high-PCDI had a worse prognosis after surgery in OV. The investigation also revealed that PCDI is associated with chemokines, interleukins, interferons, and checkpoint genes, as well as important components of the immune microenvironment, as determined through a comprehensive analysis of bulk and single-cell transcriptomes. In addition, we also found that patients with low-PCDI values may exhibit sensitivity to immunotherapy, while those with high PCDI values may display increased responsiveness to tyrosine kinase inhibitors. Conclusion This study provides new insights into the significance of programmed cell death (PCD) patterns in ovarian cancer patients following surgery. Through a comprehensive analysis of different cell death patterns, we have developed a novel PCD model that can effectively predict the clinical prognosis and drug sensitivity of OV patients post-surgery.
An epidemiological modeling framework to inform institutional-level response to infectious disease outbreaks: A Covid-19 case study
Authors: Rennert Lior , Ma Zichen
Published: July 2023

Institutions have an enhanced ability to implement tailored mitigation measures during infectious disease outbreaks. However, macro-level predictive models are inefficient for guiding institutional decision-making due to uncertainty in local-level model input parameters. We present an institutional-level modeling toolkit used to inform prediction, resource procurement and allocation, and policy implementation at Clemson University throughout the Covid-19 pandemic. Through incorporating real-time estimation of disease surveillance and epidemiological measures based on institutional data, we argue this approach helps minimize uncertainties in input parameters presented in the broader literature and increases prediction accuracy. We demonstrate this through case studies at Clemson and other university settings during the Omicron BA.1 and BA.4/BA.5 variant surges. The input parameters of our toolkit are easily adaptable to other institutional settings during future health emergencies. This methodological approach has potential to improve public health response through increasing the capability of institutions to make data-informed decisions that better prioritize the health and safety of their communities while minimizing operational disruptions.
Sensitivity of DNA double-strand break loci is coupled with spatial interaction density of chromatin
Authors: Chen Hebing , Xu Kang , Chen Bijia , Xie Qiu , Sun Yu , Xu Xiang , Wang Junting , Li Yaru , Hu Pengzhen , Yue Shutong , Yu Guoxian , Wang Jun , Li Hao , Bo Xiaochen
Published: July 2023

Background: DNA double-strand breaks, one of the most serious types of damage to the genome, are closely related to chromatin rearrangement and oncogene activation. However, the mechanisms of DSB formation and repair upon the genome are still unclear. Recent advances in chromatin conformation capture technology Hi-C enable clear identification of the relationship between chromatin 3D structure and DSBs. Nonetheless, how to interpret this relationship, especially the contribution to DSB formation at the level of TAD, remains poorly understood.
Results: Here, we classify the collected DSB data for systematic identification and annotation of these DSB loci from a multi-omics perspective, and construct a systematic framework for studying DSBs. In addition, we propose a model for TAD Density. TAD Density can well characterize the relationship between different TAD internal interaction densities and DSB occurrence. The dynamic changes of TAD Density tend to be associated with the enrichment of fragile regions of the genome or even essential genes. This relationship was explained by the ancient Chinese mythology “Journey to the West”. Furthermore, with TAD Density, we screened for genes associated with prognosis of tumor patients.
Conclusions: In conclusion, our study systematically compared and annotated DSB loci in terms of sequence features, epigenetic modifications, and the three-dimensional structure of chromatin. While validating the general pattern of DSBs, we propose a mechanism for chromatin interaction density within TAD to protect the genome from DSB damage.
The effect of weight-bearing conditions on toe joint angles in healthy volunteers using weight-bearing CT
Authors: Mens M. A. , Bouman C. M. B. , Dobbe J. G. G. , Bus S. A. , Nieuwdorp M. , Maas M. , Wellenberg R. H. H. , Streekstra G. J.
Published: July 2023

Purpose: To determine the effect of weight-bearing (WB) conditions on toe joint angles in healthy volunteers using WB and non-WB (nWB) CT images and to evaluate left and right foot differences.
Methods: In twenty healthy volunteers WB and nWB CT images of both feet were acquired. Bones of the forefoot were segmented and the respective bone models were used to calculate angles for the metatarsophalangeal and interphalangeal joints.
Results: Metatarsophalangeal joint (MTPJ) angles ranged between 6˚ and 40˚, proximal interphalangeal joint (PIPJ) angles between 0.5˚ and 54˚and distal interphalangeal joint (DIPJ) angles between 1˚ and 46˚.MTPJ angles were significantly smaller in WB compared to nWB conditions in the first four digits. The interphalangeal joint angles of the first digit was in WB conditions significantly larger. No left-right foot differences were found for toe joint angles.
Conclusion: Toe joint angles show a wide variety between healthy volunteers although the bilateral symmetry is high. MTPJ angles of the first to fourth toe are smaller under WB conditions, but do not change PIPJ and DIPJ angles compared to nWB conditions.
Does the Law Make Sense in Advancing Women’s Rights to Sexual and Reproductive Health in Uganda? Experiences from Eastern Uganda
Authors: Kagaha Alexander
Published: July 2023

This paper is based on an ethnographic investigation of experiences of abortion care delivery in eastern Uganda between August 2018- March 201 Advances on liberalization of the law on abortion as an avenue for advancement of women’s freedom and rights to sexual and reproductive health. However, findings from both public and private profit-making health facilities, indicate that: (i) Inside liberalized contexts, all aspects of life (including care practice, and the restrictive law on abortion), was evaluated in the image of the economy. The boundary between right and wrong, legal and illegal is replaced with instrumental viability based on the level of economic value. (ii) Abortion care delivery can no longer be universally interpreted. In profit making health facilities, provision of abortion care service was motivated by the desire for pecuniary interests and so, care was interpreted as a means towards financial goals. Healthcare delivery practice that can be considered to be inherently good without any qualification-were largely observed within publicly owned health facilities. The tension between the duty to serve and the desire to make profits undermine the ethic of duty to care. (iii) Abortion care involved use both allowed and prohibited medical technologies, whose choice and application were mediated through the desire for money. Use of medical technologies in panic triggered fear, resulting in increased risks injuries to patients and this also introduced maladaptive practices in care. Therefore, restrictive boundaries and regulation create dark zones in healthcare, which are difficult to monitor and regulate. Removal of legal restrictions is necessary to bring abortion care under full control and regulation health regulatory bodies.
Prenatal polycyclic aromatic hydrocarbon exposure and asthma at age 8-9 years in a multi-site longitudinal study
Authors: Sherris Allison R. , Loftus Christine T. , Szpiro Adam A. , Dearborn Logan , Hazlehurst Marnie F. , Carroll Kecia N. , Moore Paul E. , Adgent Margaret A. , Barrett Emily S. , Bush Nicole R. , Day Drew B. , Kannan Kurunthachalam , LeWinn Kaja Z. , Nguyen Ruby H.N. , Ni Yu , Riederer Anne M. , Robinson Morgan , Sathyanarayana Sheela , Zhao Qi , Karr Catherine J.
Published: July 2023

Background and aim: Studies suggest prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) may influence wheezing or asthma in preschool-aged children. However, the impact of prenatal PAH exposure on asthma and wheeze in middle childhood remain unclear. We investigated these associations in diverse participants from the ECHO PATHWAYS multi-cohort consortium.Methods We included 1,081 birth parent-child dyads across five U.S. cities. Maternal urinary mono-hydroxylated PAH metabolite concentrations (OH-PAH) were measured during mid-pregnancy. Asthma at age 8–9 years and wheezing trajectory across childhood were characterized by caregiver reported asthma diagnosis and asthma/wheeze symptoms. We used logistic and multinomial regression to estimate odds ratios of asthma and childhood wheezing trajectories associated with five individual OH-PAHs, adjusting for urine specific gravity, various maternal and child characteristics, study site, prenatal and postnatal smoke exposure, and birth year and season in single metabolite and mutually adjusted models. We used multiplicative interaction terms to evaluate effect modification by child sex and explored OH-PAH mixture effects through Weighted Quantile Sum regression.Results The prevalence of asthma in the study population was 10%. We found limited evidence of adverse associations between pregnancy OH-PAH concentrations and asthma or wheezing trajectories. We observed adverse associations between 1/9-hydroxyphenanthrene and asthma and persistent wheeze among girls, and evidence of inverse associations with asthma for 1-hydroxynathpthalene, which was stronger among boys, though tests for effect modification by child sex were not statistically.Conclusions In a large, multi-site cohort, we did not find strong evidence of an association between prenatal exposure to PAHs and child asthma at age 8–9 years, though some adverse associations were observed among girls.
Uniformization and collimation of a high-power blue EESLD
Authors: Gu Han , Luo SaiYu , Geng Xiang , Tang Xiao , Li Li
Published: July 2023

Delivering the highest power among the visible diodes, semiconductor lasers at 450 nm have been extensively applied in biomedical and micro-processing fields. However, the edge-emitting inherence that gives birth to the divergent and ununiform profile largely prohibits the practice due to the fiber coupling and pumping difficulty. To address these challenges, we propose and demonstrate a scheme that is both robust and cost-effective. A laser spot with 3×3 mm2 profile, 0.86 mrad divergence and 87.28% uniformity is experimentally achieved. Further simulation reveals that the coupling efficiency into a S460-HP single-mode fiber by a 20-mm focus-lens can reach 58.35%.
Remaining Useful Life Prediction of Lithium-ion Batteries using Particle Filter Algorithm in Communication Power Supply
Authors: Wu Zichen , Wang Yicheng , Zhang Yunxiang , Gu Bin , Xu Mi
Published: July 2023

With the development of communication technologies, the technology of power support, particularly the technology of lithium-ion batteries plays an important role in the communication area. The evaluation for the remaining useful life of lithium-ion batteries is a hot issue, to provide the maintenance plans and ensure the reliability and safety of system. In this paper, a method using particle filter algorithm for the remaining useful life prediction of lithium-ion batteries in communication power supply is carried out, and the comparisons of prediction effect with the least square method are investigated. From the results, it is clearly seen that the proposed particle filter algorithm presents a better prediction accuracy and stability than the least square method. In addition , the proposed particle filter algorithm presents a weak data dependence than the least square method. For a better prediction result, the number of data to be predicted by the proposed particle filter algorithm accounts about 55% of the total number of the cycle time, which is smaller than that accounts 70% by the least square method. This paper provides a technology support for the remaining useful life prediction of lithium-ion batteries.
Evaluation of growth and angiogenesis inhibition effect of Ritanserin on COX2 and EGFR in model of HT29 (colon cancer) incubation in nude mice
Authors: Hosseinzadeh Fatemeh , Ataee Ramin , Nasirikenar Mehrab , Kavoosian Saeid , Ghalehnoei Hossein , Mollaei Aghil , Fattahy Esamil
Published: July 2023

Background
. One of the most common cancers of the gastrointestinal tract is colorectal cancer, According to some studies, serotonin can play a proliferative role by stimulating the cAMP-dependent MAPK pathwayAlso there are some evidences about role of 5HT receptors in some cancers as gastrointestinal,breast and bladder and breast cancers .
Objective
According to these backgrounds,we have aimed to investigate the effect of 5HT2A receptor antagonist (ritanserin) on expression of apoptotic and angiogenesis factors as (Cox2 and EGFR) in an In vivo model in nude mice .
Methods
The drugs were injected into mice for 21 days, and intradermal tumor was induced by injecting 10,000,000(HT29) suspension of colorectal cell into the flank muscle of nude mice. Tumor size were examined macroscopically three times a week. After three weeks, the mice were killed and the tumor tissue was removed and the Real-time PCR method was used to evaluate the angiogenic genes of EGFR and COX2 expression. The DATA analyzed by Friedman test and One-way ANOVA and post TUKEY-TEST with 21 SPSS software with P value < 0.05
Results
In control group, there was no significant difference between tumor volumes on the three dates.( p-value = .166( and In Ritanserine-Cisplatin group, there was significant difference between tumor volumes on the three dates(p-value = 0.018)..And the difference between the first and third times.( p-value = 0.014.Also in Ritansern group, There is a significant difference between the first and third times,( p-value = 0.009). But there is no significant difference between the second and third times (p-value = 0.024).,The effect of ritanserin on the expression of inflammatory(Cox2) and angiogenesis(EGFR) factors in tumors have shown that expression of cox2 gene in cisplatin group has been increased (51/63 compared with control .Also ritanserin have increased this expression (11/31) compared with control(1/00) and this effect for cis-rit was more pronounced (70/71)and this effect for both ritanserin and rit-Cis was not significant compared with control.P > 0.05 .Also expression of EGFR as an angiogenic factor was increased by ritanserine (6.23) and combination of rit + cis had synergistic effect (36.28)
Conclusion
Our study has shown that Ritanserin as 5HT2A receptor antagonist has anti-tumor and anti-angiogenic effect in xenograft model in nude mice which some parts of its' effect could be through inhibition of COX2 as an inflammatory factor and EGFR as angiogenic factor .
Adipose Tissue Stromal Fraction Effect in the Treatment of Osteochondral Defects in Rabbits
Authors: DE OLIVEIRA ARIANE BARBOZA , MADEIRA MARINA CAZARINI , ROSADO ISABEL RODRIGUES , MARTIN IAN , BERTASSOLI BRUNO MACHADO , DE MACEDO SUZILAINE ALVES OLIVEIRA , MOTA FRANCISCO CLÁUDIO DANTAS , ALVES ENDRIGO GABELLINI LEONEL
Published: July 2023

Background:
This study aimed to evaluate the efficiency of stromal derived from adipose tissue in the treatment of osteochondral defects in rabbits. A total of 36 white New Zealand rabbits were used: 24 to perform an osteochondral defect in the trochlear groove of the joints and 12 to collect adipose tissue in the region of the adipose panicle, divided in three digestion times (30, 45 and 50 minutes). The groups were divided into negative control (C-), stromal fraction of adipose tissue (SFAT) and positive control (C+) with autogenous osteochondral graft.
Results:
Clinical, radiographic, macroscopic and histopathological evaluations showed that the therapeutic effects of the stromal fraction of adipose tissue minimized the degenerative signs of articular cartilage in the treatment of osteochondral defects in rabbits.
Conclusion:
The digestion time of 30 minutes was the best option for obtaining the stromal fraction from adipose tissue of rabbits and its use at the lesion site was satisfactory, without any immunological complications, indicating potential as an alternative for the treatment of osteochondral defects.
Academic Performance in Moderately and Late Preterm Children in the United States: Are They Catching Up?
Authors: Lock Nicole , DeBoer Mark , Scharf Rebecca , Miller Sarah
Published: July 2023

Objective: To determine whether preterm birth of 32-36 6/7 weeks gestation affected school performance from kindergarten through fifth grade.
Study Design: We assessed 14350 full-term infants and 1195 moderately and late preterm infants followed in the Early Childhood Longitudinal Study Kindergarten 2011 cohort for classroom performance in kindergarten-fifth grade. Multivariable regression was performed for comparisons, and data were weighted to be representative of the U.S. population.
Results: Children born late preterm had no significant difference in their academic scores or performance, while moderately preterm children had lower academic scores and teacher performance scores when compared to full-term children. Both moderately and late preterm children had higher odds of individualized education plan needs and had learning disability diagnoses.
Conclusions: Moderately preterm children have poor school performance compared to full-term children. Both moderately and late preterm children are at risk for learning disabilities and likely benefit from continued support and services to improve achievement throughout school.
Landscape Digital Gene: On the Logic of Landscape digitalization——a study of Nanxun Ancient Town, Zhejiang Province，China
Authors: SA Qier , Liu Yangyang , Shan Weilun , Wu Si
Published: July 2023

In recent years, the digitalization of ancient villages and towns has been iterated and updated with the development of technology, and a series of new experiences, new consumption and new scenes have become the new engine for the development of ancient towns. Ancient towns are an important branch of human cultural heritage. However, the digitalization of ancient towns has the problem of "emphasizing technology and neglecting culture" to some extent. Based on the theory of landscape gene, this paper puts forward the principles of cultural landscape digital gene and landscape digital gene. In the process of digital transformation of ancient towns, digital genes of cultural landscape should be identified from a new perspective of genetic attributes. In the process of digital transformation of ancient town, the digital gene of cultural landscape plays the role of decoder, realizing the process of "cultural decoding - cultural coding". Under this framework, the paper conducted an empirical study of Nanxun Ancient Town, Huzhou, China, a world Heritages listed ancient town, proposed a digital path for Nanxun Ancient Town according to the steps of landscape gene extraction, landscape digital gene generation and landscape digital transformation, and constructed the digital transformation path of Nanxun Ancient Town. The research aims to provide new ideas for the digitalization of scenic spots, especially the digitalization of cultural heritage, and put forward thoughts on the risk prevention of "digital destruction" of heritage scenic spots.
Properties of relativistic hot accretion flow around rotating black hole with radially varying viscosity
Authors: Singh Monu , Das Santabrata
Published: July 2023

We examine the effect of variable viscosity parameter ($\alpha$) in relativistic, low angular momentum advective accretion flow around rotating black holes. Following the recent simulation studies of magnetohydrodynamic disk that reveal the radial variation of $\alpha(r)$, we theoretically investigate the properties of the global transonic accretion flow considering a one-dimensional power law prescription of viscosity parameter as $\alpha(r) \propto r^{\theta}$, where the viscosity exponent $\theta$ is a constant. In doing so, we adopt the relativistic equation of state and solve the fluid equations that govern the flow motion inside the disk. We find that depending on the flow parameters, accretion flow experiences centrifugally supported shock transition and such shocked accretion solutions continue to exist for wide ranges of the flow energy, angular momentum, accretion rate and viscosity exponent, respectively. Due to shock compression, the hot and dense post-shock flow (hereafter PSC) can produce the high energy radiations after reprocessing the soft photons from the pre-shock flow via inverse Comptonization. Since PSC is usually described using shock radius ($r_s$), compression ratio ($R$) and shock strength ($S$), we study the role of $\theta$ in deciding $r_s$, $R$ and $S$, respectively. Moreover, we obtain the parameter space for shock and find that possibility of shock formation diminishes as $\theta$ is increased. Finally, we compute the limiting value of $\theta$ ($i.e., \theta^{\rm max}$) that admits shock and find that flow can sustain more viscosity when it accretes onto rapidly rotating ($a_{\rm k} \rightarrow 1$) black hole in comparison to weakly rotating ($a_{\rm k} \rightarrow 0$) black hole.
Preparation and characterization of biodegradable polylactic acid/poly (butyleneadipate- co-terephthalate) melt-blown nonwovens for oil-water separation
Authors: Yu JinShuo , Zhao Tao , Li Chentao , Pan Hongwei , Tan Zhiyong , Yang Huili , Zhang Huiliang
Published: July 2023

In this work, polylactic acid/poly (butylene adipate-co-terephthalate) (PLA/PBAT) melt-blown nonwovens with well oil-water separation properties were made with melt-blown technology. The thermal, crystalline, morphology, mechanical properties, wettability, and oil-water separation performance of the PLA/PBAT melt-blown nonwovens were thoroughly investigated. The result of DSC and WAXD show that PBAT promotes the movement of the PLA molecular chain and promotes crystallinity. With increasing the blending ratio of PBAT, the ΔHm and degree of crystallinity (Xc) of PLA were also enhanced from 38.1 to 55.1 J/g and from 1.5–15.5%, respectively, which were higher than neat PLA. Furthermore, PBAT increases the toughness and hydrophobic of the PLA melt-blown nonwovens. The elongation at break of PLA/PBAT 90/10 (53.3 ± 3.7%) was 12.3% higher than the neat PLA melt-blown nonwovens (41.0 ± 2.9%). The result of the research on the influence of the oil-water separation parameters and oil absorption experiments shows that the 90/10 PLA/PBAT melt-blown nonwoven exhibits the highest hydrophobic (water contact angle is 133.2o). Meanwhile, the maximum adsorption efficiency of cyclohexane of nonwovens reaches 5.18 g/g. The PLA/PBAT melt-blown nonwovens have excellent oil-water separation capability.
Giant retroperitoneal liposarcoma : a case report
Authors: Wei Feng , Ding Jun , Deng Lin
Published: July 2023

Background: Giant dedifferentiated liposarcoma in the abdomen is a rare and aggressive malignancy and poses significant challenges in clinical management.
Case presentation: A 48-year-old female presented with a sudden increase in abdominal size. Ultrasonography and MRI performed at our hospital revealed a massive abdominal mass with undetermined characteristics. The patient underwent a mass excision surgery at our hospital and had a good postoperative recovery. The pathological examination revealed dedifferentiated liposarcoma.
Conclusions: The sudden enlargement of an abdominal mass should raise our attention, as the treatment and diagnostic criteria for dedifferentiated liposarcoma pose challenges. It requires clinical doctors to pay close attention to the condition.
Thermal Plasma Spheroidization and Characterization of Stainless Steel Powders Using DC Plasma Technology
Authors: Galvagno Sergio , Iovane Pierpaolo , Borriello Carmela , Portofino Sabrina , Tammaro Loredana , Rametta Gabriella
Published: July 2023

The production of spherical powders has recently registered a boost due to the need of fabricating new printing materials for Additive Manufacturing applications, from polymers and resins to metals and ceramics. Among these materials, stainless steels powders play a leading role, since they are widely used in industry and everyday life; indeed, micron-sized spherical stainless-steel powders have specific characteristics and are considered as one of the best candidates for Additive Manufacturing systems and for the application in a wide range of sectors. In this paper, stainless steel 316L powders were used to explore and identify the best process parameters of a thermal plasma process able to produce spherical powders for Additive Manufacturing applications. X Ray Diffraction, Scanning Electron Microscopy and Flowability analysis were performed to characterize reagents and products. Powders with high circularity (> 0.8) and improved flowability (< 30 sec / 50g) were successfully obtained. The collected results were compared with data available in the literature to identify the potential use of the spherical produced powders.
Influenza-associated invasive aspergillosis in patients admitted to the intensive care unit in Sweden: A prospective multicentre cohort study
Authors: Krifors Anders , Blennow Ola , Påhlman Lisa I. , Gille-Johnson Patrik , Janols Helena , Lipcsey Miklos , Källman Jan , Tham Johan , Aspelund Anna Stjärne , Ljungquist Oskar , Hammarskjöld Fredrik , Hällgren Anita , De Geer Lina , Lemberg Marie , Petersson Johan , Castegren Markus
Published: July 2023

Purpose The purpose of this study was to prospectively investigate the incidence of influenza-associated pulmonary aspergillosis (IAPA) in influenza patients admitted to intensive care units in Sweden.Methods The study included consecutive adult patients with PCR-verified influenza A or B in 12 Swedish intensive care units (ICUs) over four influenza seasons. Patients were screened using serum galactomannan and β-d-glucan tests and fungal culture of a respiratory sample at inclusion and weekly during the ICU stay. Bronchoalveolar lavage was performed if clinically feasible. IAPA was classified according to recently proposed case definitions.Results The cohort included 55 patients; 42% were female, and the median age was 59 (IQR 48–71) years. All patients had at least one galactomannan test, β-d-glucan test and respiratory culture performed. Bronchoalveolar lavage was performed in 24 (44%) of the patients. Five (9%, 95% CI 3.8% − 20.4%) patients were classified as probable IAPA, of which four lacked classical risk factors. The overall ICU mortality was significantly higher among IAPA patients than non-IAPA patients (60% vs 8%, p = 0.01).Conclusion The study represents the first prospective investigation of IAPA incidence. The 9% incidence of IAPA confirms the increased risk of invasive pulmonary aspergillosis among influenza patients admitted to the ICU. Therefore, it appears reasonable to implement a screening protocol for the early diagnosis and treatment of IAPA in influenza patients receiving intensive care.Trial registration ClinicalTrials.gov NCT04172610, registered November 21, 2019
Synthesis and Its Urea Adsorption Capacity of Strong Acidic Hollow Nanoparticle
Authors: Huang Yiheng , Mou Youyou , Jiang Yifan , Li Maoyun , Yu Hong , Shen Jia-Wei , Guo Yong
Published: July 2023

To enhance the quality of life for dialysis patients while maintaining economic efficiency, the concept of a wearable artificial kidney was proposed and designed approximately two decades ago. However, the primary challenge in the development of a wearable artificial kidney is the adequate removal of urea from dialysate due to its chemical inertness under physiological conditions. Herein, a hollow polystyrene nanoparticle with sulfuric acid groups, named H-CPS-SO3H, was synthesized, which could efficiently adsorb urea. H-CPS-SO3H was produced in three steps. First, a core-shell polystyrene nanoparticle with a linear core and cross-linked shell was prepared using modified emulsion polymerization. Second, the core-shell nanoparticle was treated with DMF to create a hollow nanoparticle. Finally, the hollow nanoparticle was subjected to sulfuric acid treatment to produce H-CPS-SO3H, which was confirmed by both TEM and FTIR analysis. The urea adsorption capacity and kinetics of the as-synthesized H-CPS-SO3H were evaluated under a 30 mM urea concentration. Results indicated that H-CPS-SO3H had a urea absorption capacity of up to 1 mmol/g, which was achieved after only two hours of adsorption at 37 ℃. These findings demonstrated the high adsorption capacity and favorable adsorption kinetics of H-CPS-SO3H. Additionally, it was observed that the adsorption capacity first increased and then slightly decreased with the decrease of pH or the increase of solution volume, while the adsorption capacity sharply decreased with the increase of ionic strength. The results suggest that the prepared H-CPS-SO3H has promising application prospects in the field of wearable artificial kidney devices.
Intra-genus dysbiosis of Streptococcus in tonsillar microbiota is associated with host immune features in rheumatoid arthritis
Authors: Li Jing , Li Shenghui , Jin Jiayang , Guo Ruochun , Jin Yuebo , Zhong Yan , Xiang Xiaohong , Sun Xiaolin , Guo Jianping , Ye Hua , Xiao Wenjing , An Yuan , Zhang Xuan , Xia BinBin , Yang Rentao , Zhou Yuanjie , Wu Lijun , Qin Junjie , He Jing , Wang Jun , Li Zhanguo
Published: July 2023

Background
Palatine tonsils are mucosa-associated lymphoid organs that constantly engage in crosstalk with commensal microorganisms and the immune system. Focal infections at tonsils have been implicated in the pathogenesis of autoimmune diseases including rheumatoid arthritis (RA), but the underlying mechanisms through which tonsils contribute to host autoimmunity remain poorly defined.
Results
We identified a significant dysbiosis of tonsillar microbiota in RA patients, which was largely associated with disease activity. RA tonsillar microbiota was featured by an expansion of opportunistic pathogenic Streptococcus species including S. pyogenes, S. dysgalactiae and S. agalactiae, along with a contraction of numerous commensal Streptococcus members like S. salivarius. By defining a Streptococcus dysbiosis index, we found that RA patients, especially those without medication, were overrepresented in the Streptococcus dysbiotic set. Moreover, the intra-genus dysbiosis of Streptococcus in tonsillar microbiota was closely correlated with abnormal expression of circulating anti-streptolysin O, LPS-binding protein, soluble CD14, T helper 17 and natural killer cells. Finally, we demonstrated that the RA-deficient S. salivarius inhibited arthritis development and autoimmune responses.
Conclusions
Collectively, our study uncovers the functional link between host immune responses and tonsillar microbiota, and demonstrates that intra-genus dysbiosis of Streptococcus species contribute significantly to host autoimmunity.