bluuebunny/crossref_metadata_2025 huggingface dataset:
Boosting Fitness Costs Associated with Antibiotic Resistance in the Gut: On the Way to Biorestoration of Susceptible Populations
Authors: Baquero Fernando , Rodríguez-Beltrán Jerónimo , Coque Teresa M. , del Campo Rosa
Published: January 2024

The acquisition and expression of antibiotic resistance implies changes in bacterial cell physiology, imposing fitness costs. Many human opportunistic pathogenic bacteria, such as those causing urinary tract or bloodstream infections, colonize the gut. In this opinionated review, we will examine the various types of stress that these bacteria might suffer during their intestinal stay. These stresses, and their compensatory responses, probably have a fitness cost, which might be additive to the cost of expressing antibiotic resistance. Such an effect could result in a disadvantage relative to antibiotic susceptible populations that might replace the resistant ones. The opinion proposed in this paper is that the effect of these combinations of fitness costs should be tested in antibiotic resistant bacteria with susceptible ones as controls. This testing might provide opportunities to increase the bacterial gut stress boosting physiological biomolecules or using dietary interventions. This approach to reduce the burden of antibiotic-resistant populations certainly must be answered empirically. In the end, the battle against antibiotic resistance should be won by antibiotic-susceptible organisms. Let us help them prevail.
Advances in Sjögren’s Syndrome Dry Eye Diagnostics: Biomarkers and Biomolecules beyond Clinical Symptoms
Authors: Wu Kevin Y. , Serhan Olivia , Faucher Anne , Tran Simon D.
Published: January 2024

Sjögren’s syndrome dry eye (SSDE) is a subset of Sjögren’s syndrome marked by dry eye symptoms that is distinct from non-Sjögren’s syndrome dry eye (NSSDE). As SSDE can lead to severe complications, its early detection is imperative. However, the differentiation between SSDE and NSSDE remains challenging due to overlapping clinical manifestations. This review endeavors to give a concise overview of the classification, pathophysiology, clinical features and presentation, ocular and systemic complications, clinical diagnosis, and management of SSDE. Despite advancements, limitations in current diagnostic methods underscore the need for novel diagnostic modalities. Thus, the current review examines various diagnostic biomarkers utilized for SSDE identification, encompassing serum, salivary, and tear analyses. Recent advancements in proteomic research and exosomal biomarkers offer promising diagnostic potential. Through a comprehensive literature review spanning from 2016 to 2023, we highlight molecular insights and advanced diagnostic modalities that have the potential to enhance our understanding and diagnosis of SSDE.
Diverse Response to Local Pharmacological Blockade of Sirt1 Cleavage in Age-Induced versus Trauma-Induced Osteoarthritis Female Mice
Authors: Maatuf Yonathan H. , Marco Miya , Unger-Gelman Shani , Farhat Eli , Zobrab Anna , Roy Ankita , Kumar Ashish , Carmon Idan , Reich Eli , Dvir-Ginzberg Mona
Published: January 2024

Objective: Previous studies have shown that the cleavage of Sirt1 contributes to the development of osteoarthritis (OA). In fact, OA was effectively abrogated by the intra-articular (IA) administration of two compounds, one blocking Sirt1 cleavage (CA074me) and the other activating Sirt1 (SRT1720), using a post-traumatically induced model (PTOA) in young female mice. In this study, we attempted to understand if this local treatment is effective in preventing age-associated OA (AOA) progression and symptoms. Design: A group of 17-month-old female C57BL/6J mice were IA administered with CA074me and/or SRT1720 or their combination. Joint histopathological analysis and bone histomorphometry were carried out, with an assessment of knee mechanical hyperalgesia. A serum analysis for NT/CT Sirt1 was carried out along with immunohistochemistry for articular cartilage to detect p16INK4A or γH2A.X. Similarly, meniscal cartilage was monitored for Lef1 and Col1a1 deposition. The data were compared for young female mice subjected to post-traumatic OA (PTOA). Results: Similar to PTOA, combination-treated AOA exhibited improved knee hyperalgesia, yet structural improvements were undetected, corresponding to unchanged NT/CT Sirt1 serum levels. Both AOA and PTOA exhibited unchanged staining for nuclear p16INK4A or γH2A.X and lacked a correlation with OA severity. Contrarily to PTOA, the combination treatment with AOA did not exhibit a local reduction in the Lef1 and Col1 targets. Conclusions: When targeting Sirt1 cleavage, the PTOA and AOA models exhibited a similar pain response to the combination treatment; however, they displayed diverse structural outcomes for joint-related damage, related to Lef1-dependent signaling. Interestingly, nuclear p16INK4A was unaffected in both models, regardless of the treatment’s effectiveness. Finally, these findings highlight the variations in the responses between two highly researched OA preclinical models, reflecting OA pathophysiology heterogeneity and variations in gender-related drug-response mechanisms.
Evaluating the Impact of Benign Prostatic Hyperplasia Surgical Treatments on Sexual Health
Authors: Kaltsas Aris , Kratiras Zisis , Zachariou Athanasios , Dimitriadis Fotios , Sofikitis Nikolaos , Chrisofos Michael
Published: January 2024

Benign prostatic hyperplasia (BPH), a prevalent condition in older men, is often managed through various surgical interventions. This narrative review aims to explore the impact of these surgical treatments on sexual function, a critical aspect of patient quality of life often overlooked in BPH management. The methodology encompassed a thorough review of contemporary surgical techniques for BPH, including prostate resection, enucleation, vaporization, and minimally invasive therapies such as UroLift, Rezum, and Aquablation. Additionally, the focus was on patient-centered outcomes, with a special emphasis on sexual health following surgery. Findings reveal that, while surgical interventions effectively alleviate BPH symptoms, they often have significant repercussions in sexual function, including erectile and ejaculatory dysfunction. However, emerging techniques demonstrate potential in preserving sexual function, underscoring the need for patient-centric treatment approaches. The study highlights the complex interplay between BPH surgery and sexual health, with minimally invasive treatments showing promise in balancing symptom relief and sexual function preservation. In conclusion, the study advocates for an integrated, interdisciplinary approach to BPH treatment, emphasizing the importance of considering sexual health in therapeutic decision-making. This narrative review suggests a paradigm shift towards minimally invasive techniques could optimize patient outcomes, marrying symptom relief with quality-of-life considerations. The need for further research in this domain is evident, particularly in understanding long-term sexual health outcomes following different surgical interventions for BPH.
Perry Disease: Bench to Bedside Circulation and a Team Approach
Authors: Mishima Takayasu , Yuasa-Kawada Junichi , Fujioka Shinsuke , Tsuboi Yoshio
Published: January 2024

With technological applications, especially in genetic testing, new diseases have been discovered and new disease concepts have been proposed in recent years; however, the pathogenesis and treatment of these rare diseases are not as well established as those of common diseases. To demonstrate the importance of rare disease research, in this paper we focus on our research topic, Perry disease (Perry syndrome). Perry disease is a rare autosomal dominant neurodegenerative disorder clinically characterized by parkinsonism, depression/apathy, weight loss, and respiratory symptoms including central hypoventilation and central sleep apnea. The pathological classification of Perry disease falls under TAR DNA-binding protein 43 (TDP-43) proteinopathies. Patients with Perry disease exhibit DCTN1 mutations, which is the causative gene for the disease; they also show relatively uniform pathological and clinical features. This review summarizes recent findings regarding Perry disease from both basic and clinical perspectives. In addition, we describe technological innovations and outline future challenges and treatment prospects. We discuss the expansion of research from rare diseases to common diseases and the importance of collaboration between clinicians and researchers. Here, we highlight the importance of researching rare diseases as it contributes to a deeper understanding of more common diseases, thereby opening up new avenues for scientific exploration.
MicroRNAs as Potential Graft Rejection or Tolerance Biomarkers and Their Dilemma in Clinical Routines Behaving like Devilish, Angelic, or Frightening Elements
Authors: Legaz Isabel , Jimenez-Coll Víctor , González-López Rosana , Fernández-González Marina , Alegría-Marcos María José , Galián José Antonio , Botella Carmen , Moya-Quiles Rosa , Muro-Pérez Manuel , Minguela Alfredo , Llorente Santiago , Muro Manuel
Published: January 2024

Allograft rejection is a widespread complication in allograft recipients with chronic kidney disease. Undertreatment of subclinical and clinical rejection and later post-transplant problems are caused by an imperfect understanding of the mechanisms at play and a lack of adequate diagnostic tools. Many different biomarkers have been analyzed and proposed to detect and monitor these crucial events in transplant outcomes. In this sense, microRNAs may help diagnose rejection or tolerance and indicate appropriate treatment, especially in patients with chronic allograft rejection. As key epigenetic regulators of physiological homeostasis, microRNAs have therapeutic potential and may indicate allograft tolerance or rejection. However, more evidence and clinical validation are indispensable before microRNAs are ready for clinical prime time.
A Study on the Radiation Cooling Characteristics of Cerambycini Latreille
Authors: Xu Jie , Liu Delei
Published: January 2024

The severe climate and energy issues require more environmentally friendly and efficient cooling methods. Radiative cooling offers a cooling solution with significant advantages. However, current radiative cooling technologies focus primarily on seeking perfect materials to achieve complete wavelength absorption. However, numerous research studies have shown that achieving such a perfect scenario is not feasible. Here, inspired by the surface of the Cerambycini Latreille, the inherent mechanism of radiative cooling functionality in the unique structure of these hairs is revealed using effective medium theory and Finite Difference Time Domain (FDTD) optical simulation analysis. Through alkaline etching and template methods, a biomimetic radiative cooling film (BRCF) was successfully fabricated. The BRCF not only efficiently reflects solar radiation but also enhances absorption in the atmospheric window wavelength range. The radiative cooling mechanism proposed in this study and the BRCF presented here may inspire researchers to further explore the field of structural radiative cooling.
Learning Quadrupedal High-Speed Running on Uneven Terrain
Authors: Han Xinyu , Zhao Mingguo
Published: January 2024

Reinforcement learning (RL)-based controllers have been applied to the high-speed movement of quadruped robots on uneven terrains. The external disturbances increase as the robot moves faster on such terrains, affecting the stability of the robot. Many existing RL-based methods adopt higher control frequencies to respond quickly to the disturbance, which requires a significant computational cost. We propose a control framework that consists of an RL-based control policy updating at a low frequency and a model-based joint controller updating at a high frequency. Unlike previous methods, our policy outputs the control law for each joint, executed by the corresponding high-frequency joint controller to reduce the impact of external disturbances on the robot. We evaluated our method on various simulated terrains with height differences of up to 6 cm. We achieved a running motion of 1.8 m/s in the simulation using the Unitree A1 quadruped. The RL-based control policy updates at 50 Hz with a latency of 20 ms, while the model-based joint controller runs at 1000 Hz. The experimental results show that the proposed framework can overcome the latency caused by low-frequency updates, making it applicable for real-robot deployment.
Mainly Visual Aspects of Emotional Laterality in Cognitively Developed and Highly Social Mammals—A Systematic Review
Authors: Gainotti Guido
Published: January 2024

Several studies have shown that emotions are asymmetrically represented in the human brain and have proposed three main models (the ‘right hemisphere hypothesis’, the ‘approach-withdrawal hypothesis’ and the ‘valence hypothesis’) that give different accounts of this emotional laterality. Furthermore, in recent years, many investigations have suggested that a similar emotional laterality may also exist in different animal taxa. However, results of a previous systematic review of emotional laterality in non-human primates have shown that some of these studies might be criticized from the methodological point of view and support only in part the hypothesis of a continuum in emotional laterality across vertebrates. The aim of the present review therefore consisted in trying to expand this survey to other cognitively developed and highly social mammals, focusing attention on mainly visual aspects of emotional laterality, in studies conducted on the animal categories of horses, elephants, dolphins and whales. The 35 studies included in the review took into account three aspects of mainly visual emotional laterality, namely: (a) visual asymmetries for positive/familiar vs. negative/novel stimuli; (b) lateral position preference in mother–offspring or other affiliative interactions; (c) lateral position preference in antagonistic interactions. In agreement with data obtained from human studies that have evaluated comprehension or expression of emotions at the facial or vocal level, these results suggest that a general but graded right-hemisphere prevalence in the processing of emotions can be found at the visual level in cognitively developed non-primate social mammals. Some methodological problems and some implications of these results for human psychopathology are briefly discussed.
Association between Depressive Mood, Antidepressant Therapy and Neuropsychological Performances: Results from a Cross-Sectional Study on Elderly Patients
Authors: Belfiori Maristella , Salis Francesco , Demelas Giorgia , Mandas Antonella
Published: January 2024

Background: Currently, the global demographic landscape is undergoing a transformative shift towards an increasingly aging population. This leads to an increase in chronic pathologies, including depression and cognitive impairment. This study aimed to evaluate the association between depressive mood, whether in treatment or not, and cognitive capacities, assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Methods: This study included 259 subjects, aged 65 years or older, evaluated at the Geriatric Outpatient Service of the University Hospital of Monserrato, Cagliari, between July 2018 and May 2022, who experienced subjective depressive mood and/or cognitive deficits. Results: Only 25.1% of the sample showed no cognitive impairment on the RBANS. Education was a significant regressor of the RBANS Total Scale scores (p < 0.0001) and was negatively associated with mood deflection (r = −0.15, p = 0.0161). Subjects with depressive mood had more impaired attention and visuospatial/constructional abilities compared to untreated euthymic patients. Post-hoc analysis, conducted with the Conover test, showed that untreated euthymic patients (GDS-15 ≤ 5, group 2) had a higher score on the RBANS total scale than patients with mood deflection (GDS-15 > 5, group 1), and treated euthymic patients (GDS-15 ≤ 5, group 3). Finally, different logistic regression analyses revealed a significant negative coefficient for GDS as a regressor of the RBANS total scale (coefficient: −0.04, p = 0.0089), visuospatial/constructional abilities (coefficient: −0.03, p = 0.0009), language (coefficient: −0.05, p = 0.0140), and attention (coefficient: −0.05, p < 0.0001). Conclusions: Our analysis demonstrated that “naturally” euthymic people show better cognitive performances than people with depressive mood and subjects with acceptable mood due to antidepressants. Furthermore, the gender-based difference observed in the language domain suggests the potential utility of incorporating an alternative category for male patients in the Semantic Fluency test.
Brain Health and Cognition in Older Adults: Roadmap and Milestones towards the Implementation of Preventive Strategies
Authors: Pozzi Federico Emanuele , Remoli Giulia , Tremolizzo Lucio , Appollonio Ildebrando , Ferrarese Carlo , Cuffaro Luca
Published: January 2024

In this narrative review, we delve into the evolving concept of brain health, as recognized by the WHO, focusing on its intersection with cognitive decline. We emphasize the imperative need for preventive strategies, particularly in older adults. We describe the target population that might benefit the most from risk-based approaches—namely, people with subjective cognitive decline. Additionally, we consider universal prevention in cognitively unimpaired middle-aged and older adults. Delving into multidomain personalized preventive strategies, we report on empirical evidence surrounding modifiable risk factors and interventions crucial in mitigating cognitive decline. Next, we highlight the emergence of brain health services (BHS). We explain their proposed role in risk assessment, risk communication, and tailored interventions to reduce the risk of dementia. Commenting on ongoing BHS pilot experiences, we present the inception and framework of our own BHS in Monza, Italy, outlining its operational structure and care pathways. We emphasize the need for global collaboration and intensified research efforts to address the intricate determinants of brain health and their potential impact on healthcare systems worldwide.
The Use of Intraoperative Microvascular Doppler in Vascular Neurosurgery: Rationale and Results—A Systematic Review
Authors: Gulino Vincenzo , Brunasso Lara , Avallone Chiara , Campisi Benedetta Maria , Bonosi Lapo , Costanzo Roberta , Cammarata Emanuele , Sturiale Carmelo Lucio , Cordova Adriana , Iacopino Domenico Gerardo , Maugeri Rosario
Published: January 2024

Surgical treatment of neurovascular lesions like intracranial aneurysms, arteriovenous malformations and arteriovenous dural fistulas is still associated with high morbidity. Several recent studies are providing increasing insights into reliable tools to improve surgery and reduce complications. Inadvertent vessel compromise and incomplete occlusion of the lesion represent the most possible complications in neurovascular surgery. It is clear that direct visual examination alone does not allow to identify all instances of vessel compromise. Various modalities, including angiography, microvascular Doppler and neurophysiological studies, have been utilized for hemodynamics of flow vessels in proper clipping of the aneurysm or complete obliteration of the lesion. We intended to review the current knowledge about the intraoperative microvascular Doppler (iMDS) employment in the most updated literature, and explore the most recent implications not only in intracranial aneurysms but also in neurovascular lesions like arteriovenous malformations (AVMs) and arteriovenous dural fistulas (AVDFs). According to the PRISMA guidelines, systematic research in the most updated platform was performed in order to provide a complete overview about iMDS employment in neurovascular surgery. Twelve articles were included in the present paper and analyzed according to specific research areas. iMDS employment could represent a crucial tool to improve surgery in neurovascular lesions. The safety and effectiveness of the surgical treatment of neurovascular lesions like intracranial aneurysm and other neurovascular lesions like AVMs and AVDFs requires careful and accurate consideration regarding the assessment of anatomy and blood flow. Prognosis may depend on suboptimal or incomplete exclusion of the lesion.
Bidirectional Relationship between Positive Parenting Behavior and Children’s Self-Regulation: A Three-Wave Longitudinal Study
Authors: Wang Su , Gai Xiaosong
Published: January 2024

In this study, we used a cross-lagged design to explore the relationship between children’s self-regulation and positive parenting behaviors. Children aged 3 years (N = 84) were tested individually three times a year for their hot and cool self-regulation, while their parents’ positive parenting behaviors (warmth, structure, and autonomy support) were collected through questionnaires. In the structural equation panel model, bidirectional relations between children’s inhibitory control and parental positive parenting were found. Children’s inhibitory control and positive parenting predicted changes in each other for the first six months. Such a reciprocal relationship also existed between parental autonomy support and children’s inhibitory control. There was a cross-lagged effect between parental warmth and children’ inhibitory control rather than a simultaneous relation. Children’s inhibitory control positively predicted parental structural behaviors rather than vice versa. Children’s delayed waiting and positive parenting (autonomy support) were only positively correlated, rather than having a lagging effect. All the relationships faded over time.
Structural Performance and Design of Aluminum Claddings Subjected to Windborne Debris Impact
Authors: Hussain Iqrar , Aghdamy Sanam , Gunalan Shanmuganathan
Published: January 2024

Aluminum cladding panels have been used in some of the most iconic buildings around the world due to their durability, aesthetic appeal, and longevity. These panels play a critical role as the first line of defense against external forces such as wind and rain; therefore, the appropriateness of the design and resilience of aluminum cladding panels must be ensured. Previous researchers have conducted very minimal research on aluminum panels subjected to windborne debris impact. Their scope was limited to studying the response of panels when they are targeted at the center. The influence of various structural and load-related parameters on the response of such claddings has yet to be investigated. Furthermore, no design guidelines are readily available that engineers can use to predict the response of aluminum cladding panels when subjected to such loads considering various conditions (location of impact, projectile’s material, angle of impact, velocity of impact, unsupported length, and the geometry of the panels). The main aim of this paper was to develop some design guidelines that engineers can use to predict the response of aluminum cladding panels exposed to windborne debris impact. To achieve this, a series of parametric studies was conducted to generate a data bank. These parametric studies were performed with the help of a robust numerical model that has been validated with experimental results. The parametric sensitivity study revealed that the angle of impact was the most influential parameter, causing an 80% reduction in the peak impact force with a 50% decrease in the angle. The velocity, plate thickness, location of impact, and unsupported length also significantly influenced the panel’s response. The alloy type emerged as a dominant factor affecting the maximum and residual deflections. Regression equations were formulated based on the generated dataset to accurately predict the peak impact force, maximum central deflection, and residual deflection of solid aluminum cladding panels. The proposed prediction equations offer a better alternative to experimental testing.
Investigating the Influencing Factors of the Perception Experience of Historical Commercial Streets: A Case Study of Guangzhou’s Beijing Road Pedestrian Street
Authors: Xie Qian , Hu Linhui , Wu Jiye , Shan Qian , Li Weicong , Shen Kang
Published: January 2024

Given the complex interplay between economic and cultural–historical factors, this paper explores scene perception and its mechanism in individual and collective cognition of historical commercial streets. Based on a perception model constructed from scene theory, the study utilizes user scene experience feedback from Beijing Road, a commercial pedestrian street in Guangzhou. It conducts a systematic assessment using hierarchical analysis (AHP) across three dimensions: authenticity, theatricality, and legitimacy. The findings reveal the following: (1) according to visitors, traditional cuisine, cultural and creative arts, and Lingnan’s intangible cultural heritage received low ratings; (2) historical relics and traditional cuisine are dominant factors, highlighting public attention to cultural heritage, but the role of historical–cultural characteristics and festival activities is relatively marginalized; (3) cultural–historical relics and traditional cuisine are the leading factors that contribute to an authentic experience, while historical context and festival activities constitute secondary factors; (4) cultural landscapes and arts are central to theatrical experiences, with modern visual elements playing a lesser role; (5) diversified commercial formats and public services are the core factors influencing legitimacy experience, reflecting the role of market diversity and policy orientation in building consumer trust. The design of historical and cultural streets should prioritize the preferences of those experiencing them to promote cultural identity and historical continuity. Additionally, the synergy between commercial diversity and policy orientation should be strategically emphasized to form a business ecosystem supporting sustainable development. Future commercial street renewals should focus on the key role of visual narrative in shaping brand culture. This paper offers insights into the dynamic process of constructing scene experience from perspectives of spatial materialization and emotional empowerment to cultural identity, providing references for strategies in historical place renewal.
Field Investigation of Water Infiltration into a Three-Layer Capillary Barrier Landfill Cover System Using Local Soils and Construction Waste
Authors: Wu Yuedong , Ren Jincheng , Liu Jian
Published: January 2024

In response to the rapid urban expansion and the burgeoning number of landfill sites, managing water infiltration in these areas has become a critical challenge, especially in cities like Shenzhen, Hong Kong, and Singapore where traditional cover materials such as silt, clayey gravel, and sand are scarce. A three-layer (silt/gravelly sand/clay) capillary barrier cover system has been proposed to address this issue in humid climates. As an alternative to scarce traditional materials, using local soils and construction waste (CW) for this system presents a viable solution. However, the real-world performance of this adapted three-layer system, constructed with local soils and CW under natural rainfall conditions, remains to be fully evaluated. This paper presents a field test evaluating the water infiltration behavior of a three-layer capillary barrier landfill cover system under natural conditions. The tri-layered system is comprised of a 0.6 m loose local unscreened soil layer, covered by a 0.4 m CW layer and topped by a 0.8 m heavily compacted local screened soil layer. Monitoring findings reveal that, during the wet season, infiltration through the top two layers was staved off until the third rainfall, after which these layers retained moisture until 15 September 2016. The fluctuation in pore water pressure in the topmost layers showed each rainfall was contingent not only on the day’s precipitation but also the hydraulic state. Beyond the hydraulic state’s influence, a deeper tensiometer showed resulted in a diminished correlation between the surge in pore water pressure and daily rainfall. This declining correlation with depth can be attributed to the capillary effect and the reduced permeability of the screened soil layer. Rainfall patterns significantly affect percolation, with the combination of a short-duration, intense rainfall and prolonged weak rainfall resulting in a marked increase in percolation. In the foundational screened soil layer, the pore water pressure remained relatively low, with the cumulative percolation over six months (June to December) registering approximately 10 mm. These findings suggest a promising performance of the three-layer capillary barrier cover system, integrating local soils and CW, in the year of the study conducted in a humid environment.
Numerical Investigation of Thermal Energy Storage Systems for Collective Heating of Buildings
Authors: Ali Emad , Ajbar Abdelhamid , Lamrani Bilal
Published: January 2024

This study aims to investigate and identify the most effective thermal energy storage (TES) system configuration for the collective heating of buildings. It compares three TES technologies, i.e., sensible, latent, and cascade latent shell and tube storage, and examines their respective performances. A fast and accurate lumped thermal dynamic model to efficiently simulate TES system performances under different operation conditions is developed. The validation of this model’s accuracy is achieved by aligning numerical findings with data from prior experimental studies. Key findings indicated that the latent and cascade latent shell and tube storage systems demonstrate superior thermal energy storage capacities compared to the sensible configuration. Using a single-phase change material (PCM) tank increases the duration of constant thermal power storage by about 50%, and using a cascade PCM tank further enhances this duration by approximately 65% compared to the sensible TES case. Moreover, the study revealed that adjusting the PCM composition within the cascade TES significantly influenced both thermal power storage durations and pumping energy consumption. In summary, the recommended cascade PCM configuration for collective heating of buildings offers a balanced solution, ensuring prolonged stable thermal power production, elevated HTF outlet temperatures, and improved energy efficiency, presenting promising prospects for enhancing TES systems in district heating applications.
Transforming Zeolite Tuff and Cigarette Waste into Eco-Friendly Ceramic Bricks for Sustainable Construction
Authors: Ibrahim Jamal Eldin F. M. , Basyooni-M. Kabatas Mohamed A. , Móricz Ferenc , Kocserha István
Published: January 2024

The use of waste materials has gained attention as a sustainable approach in various industries. Cigarette waste, which is typically discarded as a non-recyclable material, poses a significant environmental challenge due to its toxicity and slow decomposition rate. However, by incorporating this waste into ceramic bricks, new approaches for waste management and resource utilization are explored. This research work provides a detailed evaluation of the possibility of utilizing natural zeolite tuff incorporated with cigarette waste to produce sustainable ceramic bricks. Uniform powders are produced by milling various combinations of zeolitic tuff and cigarette waste using a planetary ball mill. The substitution ratios ranged from 0% to 12% by weight of the zeolitic tuff, with increments of 2%. Ceramic discs were formed by dry pressing and then subjected to sintering at different heat treatment temperatures (950–1250 °C). The impact of the inclusion of cigarette waste on the microstructural and technical features of zeolite tuff-based ceramic bricks has been thoroughly investigated. The results of the experiments demonstrate that incorporating cigarette waste into the development of ceramic bricks leads to improved thermal insulation properties, with thermal conductivity ranging from 0.33 to 0.93 W/m·K. Additionally, these bricks exhibit a lighter weight in a range of 1.45 to 1.96 g/cm3. Although the inclusion of cigarette waste slightly reduces the compressive strength, with values ranging from 6.96 to 58.6 MPa, it still falls within the acceptable range specified by standards. The inclusion of cigarette waste into zeolite tuff is an innovative approach and sustainable practice for reducing energy consumption in buildings while simultaneously addressing the issue of waste disposal and pollution mitigation.
Carbon Emission Accounting during the Construction of Typical 500 kV Power Transmissions and Substations Using the Carbon Emission Factor Approach
Authors: Liu Ti , Wu Zhen , Chen Cong , Chen Huan , Zhou Hongyang
Published: January 2024

Carbon emission calculation during power transmission and substation construction provides valuable insights into the trend of carbon emissions and the development of low-carbon power grids. In this regard, this study divides the power transmission and substation construction process into production, transportation, and construction stages based on the sources of carbon emissions and employs a life cycle assessment to calculate the total carbon emissions using the carbon emission factor method for typical 500 kV projects. The results show that in the construction process the production stage contributes the most carbon emissions, with material and equipment production for power transmission accounting for 78% and 14% of the total emissions, respectively. The transportation and construction stage contribute 1% and 7% of the total emissions, respectively. For substations, material and equipment production contribute 67% and 30% of the total emissions, respectively. The transportation and construction phases contribute 1% and 2% of the total emissions. Through the qualitative and quantitative analysis of the carbon emission results, the construction scale and the topography and geology have significant impacts on carbon emissions from power transmission and substation projects. Finally, some targeted recommendations for carbon emission reduction for power transmissions and substations are proposed based on the influencing factors of each stage of the construction.
Study on Numerical Simulation of Arch Mechanism of Bridge Pile Foundation
Authors: Qu Zhanhui , Han Zemin , Tang Haoyu , Xu Jiangbo , Wang Heping , Liu Yifan
Published: January 2024

Bridges are situated in a complex area with geological conditions that are challenging for engineering. It has been observed that certain pile foundations of bridges have been uplifted to varying degrees by up to 309 mm. This has a significant impact on the bridge’s operation and driving safety. The causal mechanism of the bridge pile foundation arch is analyzed through a theoretical analysis and a Plaxis 3D (v.2013) finite element software simulation. The influence of the ground stress and goaf on the bridge pile foundation under different working conditions is studied. The findings indicate that the uplift of the bridge pile foundation due to an equivalent ground stress is the largest, reaching approximately 300 mm in the bridge valley area. Additionally, the uplift of the non-bridge area in the goaf is greater than that of the bridge pile foundation. These results suggest that ground stress is the primary cause of the arching of a bridge pile foundation.
Moment Redistribution in UHPC Continuous Beams Reinforced with High-Strength Steel Bars: Numerical Investigation and Prediction Model
Authors: Li Ling , Li Bei , Zheng Wenzhong
Published: January 2024

Considering moment redistribution in the design of ultra-high-performance concrete (UHPC) statically indeterminate structures can fully exploit the load-bearing potential of members, simplify reinforcement details, and save construction costs. Due to the excellent properties of ultra-high-performance concrete (UHPC) that distinguish it from conventional concrete, new characteristics of the moment redistribution manifest in UHPC structures. In this study, a finite element (FE) analytical model was developed to simulate and analyze the bending behavior and moment redistribution of UHPC continuous beams reinforced with high-strength steel bars. The simulation and test results exhibited excellent agreement with the experimental research. Based on the FE model, a fine analysis for nine simulated two-span UHPC continuous beams was conducted with a detailed discussion of the failure modes, load-displacement curves, variations of support reaction forces, tensile strains of steel bars, and the whole process of moment redistribution. Subsequently, the variation rules of moment redistribution in UHPC continuous beams were explored by an extensive parametric study of 108 simulated beams. The studied parameters included a neutral axis depth factor, concrete strength, yielding strength of reinforcement, beam depth, span–depth ratio, reinforcement ratio between the mid-span and intermediate support section, as well as load forms. According to the numerical results, new formulas for estimating the two-stage moment redistribution in UHPC continuous beams with high-strength reinforcement were established. Finally, a comparison of moment redistribution between normal concrete continuous beams and UHPC continuous beams was performed. It can be observed that the elastic moment distribution in UHPC continuous beams was comparatively smaller, while the plastic moment distribution was relatively larger than those of normal concrete continuous beams. Overall, the degree of the total moment distribution in UHPC structures was greater than that of normal concrete structures due to the high ductility of UHPC. The research in this study may provide a technical reference for the practical engineering of UHPC.
A Subpixel Concrete Crack Measurement Method Based on the Partial Area Effect
Authors: Zheng Jiayan , Liu Yan , Luo Renwei , Liu Haijing , Zhou Zhixiang , He Ji
Published: January 2024

To improve the accuracy of concrete crack measurement with a machine vision method in structural health monitoring and in technical status evaluation, a subpixel crack measurement method based on the partial area effect was proposed. (1) First, a pixelwise crack image segmentation method was established through a multi-step process of multi-threshold fusion and morphology operation, and a novel pixel degree crack width calculation method was developed with the extraction of the middle points, the center line and its normal, and the intersection of the center line normal and crack edges. (2) Then, a subpixel algorithm based on the partial area effect was introduced to locate vertical, horizontal, and oblique cracks in subpixel crack edges, and the subpixel crack width could be calculated along the crack center line pixelwise. (3) Finally, the proposed method was verified by indoor concrete beam crack measurement tests with a digital microscope, and the results show that the maximum relative errors of the subpixel width of the horizontal, vertical, and oblique straight cracks measured by the proposed method were 3.06%, 8.97%, and 5.16%, respectively. The absolute error of the crack length was less than 0.30 mm, and the measurement accuracy could reach 0.01 pixels. The subpixel crack measurement method provides a novel possible solution for structural health monitoring.
Experimental Investigation on the Rehabilitation of RC Flat Slabs Using CFRP Sheets to Enhance Punching Shear Capacity
Authors: Abdul Sahib Mohammed Qusay , Aghayari Reza , Moradi Mohammad Javad , Tahamouli Roudsari Mehrzad
Published: January 2024

In this paper, the feasibility of strengthening a flat column–slab connection within the carbon fiber reinforced polymer (CFRP) has been investigated through experimental study. The experimental program includes a set of nine reinforced concrete flat slab specimens. Three unaltered specimens served as control slabs, while an additional six samples were strengthened with various CFRP configurations to enhance their shear capacity. The strain distribution, ductility, punching shear resistance, stiffness, and crack formation were studied. The result of experimental studies showed that in the direct method of strengthening in which two layers of unidirectional CFRP sheets were employed in two opposite directions, the ultimate punching shear resistance improved by 64%, 44.7%, and 15.3%, with respect to the location of the column connection, as compared with the control specimens. In the case of using one layer of unidirectional CFRP strips, the punching shear resistance was enhanced by approximately 16% and 39%, considering the configuration of CFRP sheets and the amount of strengthened and adhesive layers used. Following the outcomes of this research, the application of CFRPs in improving the resistance capacity of flat slabs against the punching shear is considerable. The reported outcomes were compared with the latest provisions of ACI to show the efficiency of the presented strengthening. Finally, a parametric study was performed assuming different loading locations to assess the effect of the loading region on the response of RC slabs. Results indicate that approaching the loading location toward the RC slab supports results of an increase in the load-bearing capacity and a reduction in the ductility of the RC slab.
Assessment of CO2 Capture in FA/GGBS-Blended Cement Systems: From Cement Paste to Commercial Products
Authors: Liu Jingxian , Wu Yingyu , Qu Fulin , Zhao Hanbing , Su Yilin
Published: January 2024

The cement industry’s intricate production process, including kiln heating and fossil fuel use, contributes 5–8% of global CO2 emissions, marking it as a significant carbon emitter in construction. This study focuses on quantifying CO2 capture potential in blended cement systems through the utilisation of phenolphthalein and thermalgravimetric methodologies. Its primary objective is to assess the CO2 absorption capacity of these blended systems’ pastes. Initial evaluation involves calculating the carbon capture capacity within the paste, subsequently extended to estimate CO2 content in the resultant concrete products. The findings indicate that incorporating ground granulated blast-furnace slag (GGBS) or an ettringite-based expansive agent did not notably elevate carbonation depth, irrespective of their fineness. Conversely, the introduction of fly ash (FA) notably augmented the carbonation depth, leading to a substantial 36.4% rise in captured CO2 content. The observed distinctions in carbonation behaviour primarily stem from variances in pore structure, attributable to distinct hydration characteristics between GGBS and FA. Thermal analysis confirms the increased stabilisation of CO2 in FA blends, highlighting the crucial influence of material composition on carbonation and emission reduction. Incorporating both GGBS and FA notably diminishes binder emissions, constituting almost half of PC-concrete emissions. Initially, 60% GGBS shows lower emissions than 50% FA, but when considering CO2 capture, this emission dynamic significantly changes, emphasising the intricate influence of additives on emission patterns. This underscores the complexity of evaluating carbonation-induced emissions in cementitious systems.
Testing Adaptive Therapy Protocols Using Gemcitabine and Capecitabine in a Preclinical Model of Endocrine-Resistant Breast Cancer
Authors: Seyedi Sareh , Teo Ruthanne , Foster Luke , Saha Daniel , Mina Lida , Northfelt Donald , Anderson Karen S. , Shibata Darryl , Gatenby Robert , Cisneros Luis H. , Troan Brigid , Anderson Alexander R. A. , Maley Carlo C.
Published: January 2024

Adaptive therapy, an ecologically inspired approach to cancer treatment, aims to overcome resistance and reduce toxicity by leveraging competitive interactions between drug-sensitive and drug-resistant subclones, prioritizing patient survival and quality of life instead of killing the maximum number of cancer cells. In preparation for a clinical trial, we used endocrine-resistant MCF7 breast cancer to stimulate second-line therapy and tested adaptive therapy using capecitabine, gemcitabine, or their combination in a mouse xenograft model. Dose modulation adaptive therapy with capecitabine alone increased survival time relative to MTD but not statistically significantly (HR = 0.22, 95% CI = 0.043–1.1, p = 0.065). However, when we alternated the drugs in both dose modulation (HR = 0.11, 95% CI = 0.024–0.55, p = 0.007) and intermittent adaptive therapies, the survival time was significantly increased compared to high-dose combination therapy (HR = 0.07, 95% CI = 0.013–0.42, p = 0.003). Overall, the survival time increased with reduced dose for both single drugs (p < 0.01) and combined drugs (p < 0.001), resulting in tumors with fewer proliferation cells (p = 0.0026) and more apoptotic cells (p = 0.045) compared to high-dose therapy. Adaptive therapy favors slower-growing tumors and shows promise in two-drug alternating regimens instead of being combined.
MASLD and the Development of HCC: Pathogenesis and Therapeutic Challenges
Authors: Phoolchund Anju G. S. , Khakoo Salim I.
Published: January 2024

Metabolic-dysfunction-associated steatotic liver disease (MASLD, previously known as non-alcoholic fatty liver disease (NAFLD)) represents a rapidly increasing cause of chronic liver disease and hepatocellular carcinoma (HCC), mirroring increasing rates of obesity and metabolic syndrome in the Western world. MASLD-HCC can develop at an earlier stage of fibrosis compared to other causes of chronic liver disease, presenting challenges in how to risk-stratify patients to set up effective screening programmes. Therapeutic decision making for MASLD-HCC is also complicated by medical comorbidities and disease presentation at a later stage. The response to treatment, particularly immune checkpoint inhibitors, may vary by the aetiology of the disease, and, in the future, patient stratification will be key to optimizing the therapeutic pathways.
CYP26A1 Links WNT and Retinoic Acid Signaling: A Target to Differentiate ALDH+ Stem Cells in APC-Mutant CRC
Authors: Facey Caroline O. B. , Hunsu Victoria O. , Zhang Chi , Osmond Brian , Opdenaker Lynn M. , Boman Bruce M.
Published: January 2024

APC mutation is the main driving mechanism of CRC development and leads to constitutively activated WNT signaling, overpopulation of ALDH+ stem cells (SCs), and incomplete differentiation. We previously reported that retinoic acid (RA) receptors are selectively expressed in ALDH+ SCs, which provides a way to target cancer SCs with retinoids to induce differentiation. Hypotheses: A functional link exists between the WNT and RA pathways, and APC mutation generates a WNT:RA imbalance that decreases retinoid-induced differentiation and increases ALDH+ SCs. Accordingly, to restore parity in WNT:RA signaling, we induce wt-APC expression in APC-mutant CRC cells, and we assess the ability of all-trans retinoic acid (ATRA) to induce differentiation. We found that ATRA increased expression of the WNT target gene, CYP26A1, and inducing wt-APC reduced this expression by 50%. Thus, the RA and WNT pathways crosstalk to modulate CYP26A1, which metabolizes retinoids. Moreover, inducing wt-APC augments ATRA-induced cell differentiation by: (i) decreasing cell proliferation; (ii) suppressing ALDH1A1 expression; (iii) decreasing ALDH+ SCs; and (iv) increasing neuroendocrine cell differentiation. A novel CYP26A1-based network that links WNT and RA signaling was also identified by NanoString profiling/bioinformatics analysis. Furthermore, CYP26A1 inhibitors sensitized CRC cells to the anti-proliferative effect of drugs that downregulate WNT signaling. Notably, in wt-APC-CRCs, decreased CYP26A1 improved patient survival. These findings have strong potential for clinical translation.