bluuebunny/crossref_metadata_2025 huggingface dataset:
¿Hombres civilizados o indios salvajes? Representaciones sobre los llaneros en la segunda mitad del siglo XIX
Authors: Flórez López Simón
Published: May 2022

Este artículo se centra en analizar las representaciones sobre los llaneros, indígenas y pioneros encontradas en un variado grupo de fuentes y referencias, siendo el objetivo principal identificar sus puntos en común para elucidar la existencia de una “estructura mental” -la escala de civilización- como un medio para jerarquizar los grupos poblacionales de los Llanos Orientales. Se propone, también, un análisis de los posibles efectos que tuvo esta escala en la “realidad” de la región y sus habitantes, recogiendo los aportes de Pierre Bourdieu en lo referente al poder de la representación.
Sobre la historia de la educación: algunas aproximaciones y reflexiones historiográficas sobre las formas contemporáneas de investigar
Authors: Rojas Yacamán Sharon
Published: May 2022

En este ensayo se abordan cuatro libros sobre la historia de la educación escritos o reeditados desde el 2012. En la introducción se hace una breve referencia a la historiografía de la educación en Colombia desde la segunda mitad del siglo XX hasta el presente. En el desarrollo se exploran los puntos de convergencia y las distancias que hay entre las investigaciones en cuanto a los ejes temáticos, teóricos y metodológicos. Finalmente, se concluye brevemente a partir de los hallazgos del ejercicio. A lo largo del balance se sostiene que las investigaciones recientes están articuladas en términos metodológicos, en tanto que trabajan desde la propuesta genealógica y arqueológica de Michel Foucault.
Convenciones contra la cultura y prisiones historiográficas. Una discusión entre Sergio Mejía y las tesis de Germán Colmenares
Authors: Prada Daniela
Published: May 2022

Este artículo propone una discusión del artículo del historiador Sergio Mejía, “¿Qué hacer con las historias latinoamericanas del siglo XIX?”, escrito en memoria de Germán Colmenares, en el que el autor discute unas de las tesis más famosas de este autor sobre la historiografía del siglo XIX. Mi propósito es debatir la crítica que Mejía hace de la tesis de Colmenares que afirma que las historias hispanoamericanas del siglo XIX son convenciones contra la cultura. En ese sentido, y partiendo de los planteamientos de Colmenares y Mejía también discutiré las posibilidades que tiene la historiografía del siglo XIX tomando como ejemplo la producción de José Manuel Restrepo. Finalmente, recogeré la crítica que hizo Colmenares a los historiadores de su época frente al trato analítico que se le ha dado a la historiografía decimonónica. Así, concluiré que la crítica es aún vigente teniendo en cuenta que algunas de las estructuras actuales con las cuales leemos e identificamos los problemas históricos en la actualidad pueden estar convirtiéndose en nuevas prisiones historiográficas.
papel de la historiografía en la construcción del mito fundacional uruguayo entre 1880 y 1930
Authors: Valdés Santiago
Published: May 2022

El rol de la historiografía en los procesos de construcción nacional en América Latina fue (y es) determinante. En este sentido, indagar por las especificidades de su desenvolvimiento en los diferentes contextos nacionales es fundamental. Para contribuir a este tipo de indagaciones, este ensayo explora las siguientes preguntas refiriéndose al caso uruguayo a finales del siglo XIX: ¿De qué forma se presentó el mito fundacional de la República Oriental del Uruguay en la disciplina histórica durante el período 1880-1930? ¿Existe algún tipo de coherencia (o desacuerdo) entre los distintos relatos? ¿Qué motivos o situaciones particulares favorecieron esta situación? y ¿qué relación mantenía la disciplina histórica con la vida política del país a este respecto?
De los conceptos surgen historias: Koselleck y la Historia Conceptual
Authors: Arias Herrera Nicolás
Published: May 2022

El presente trabajo tiene como propósito exponer sucintamente los objetivos, métodos y retos que implican trabajar con el método de la Bregriffgeschichte o Historia Conceptual, propuesta por el historiador alemán Reinhart Koselleck. En primer lugar, se explican el significado y la importancia de la categoría “concepto” para esta escuela historiográfica. A continuación se exponen las consideraciones metodológicas sobre el trato de los conceptos en la historia, su relación con el tiempo histórico y con las meta-categorías que Koselleck propone en su análisis. Seguidamente se profundiza en la relación de la Historia Conceptual con la Historia Social, pues para Koselleck es fundamental entender cómo los conceptos se desarrollan en la vida práctica. Finalmente se considerará cómo ha sido la apropiación que América Latina ha hecho de esta propuesta investigativa, y cuáles son las limitantes epistemológicas que deben ser superadas en la Historia Conceptual.
Actuar y comprender: el significado del acontecimiento
Authors: Reyes Jacqueline
Published: May 2022

En el texto La condición humana, Hannah Arendt presenta la Historia como una narración sin autor, sin comienzo ni fin, sin otro protagonista que la humanidad abstracta. Los héroes en la Historia, quienes tienen la valentía de comunicar su yo más allá de la necesidad, actúan para obtener el brillo que solo da la mirada de los otros, para hacerse recuerdo, pero no pueden medir las consecuencias de su acción, que por definición es ilimitada e incalculable. El único autor de la Historia es el historiador, quién puede comprender el significado de la acción gracias a la luz del acontecimiento singular; por esto para Arendt la Historia es un ejercicio de comprensión y el historiador lejos de pretender ser un científico debe ser un hombre de acción.
Monitoring of Enzymatic Activity in the Gastrointestinal Tract of Black Sea Salmon (Salmo labrax Pallas, 1814)
Authors: Özel Osman Tolga , Ertürk Gürkan Selin
Published: May 2022

In this study, it was aimed to determine the activity of digestive enzymes at different time intervals after-feeding throughout the gastrointestinal tract of Black Sea salmon (Salmo labrax). The study was conducted at freshwater recirculating aquaculture systems (RAS). The fish were fed by hand up to satiation for 60 days with diets containing 46.25% protein and 14.90% lipid. The fish gastrointestinal tract including stomach, anterior (with pyloric caeca), middle and posterior sections were taken together at 45th minute, 3rd, 6th, 12th, 24th, 48th, 72nd, and 96th hours post-feeding. The tissues were were stored at -80°C until analyzed. In terms of digestive enzyme activity, at the end of the study, anterior and middle intestine sections had the highest level at 3rd-hour post-feeding. Similarly, pepsin, trypsin, and lipase in the stomach had the highest activity at 3rd-hour post-feeding. However, amylase in the stomach was the highest level at 45th minute and 3rd-hour post-feeding. At 3rd-hours post-feeding, the pepsin in the stomach, the trypsin, and lipase in the anterior section, and the amylase in the middle intestine had the highest levels. Moreover, the correlations between these enzymes were strong in the positive direction. Also, the difference in pepsin, trypsin, amylase, and lipase levels in the samples dissected at different time intervals after feeding was statistically significant. Our results revealed that stomach, anterior, middle, and posterior sections in the gastrointestinal tract of Black Sea salmon had enzyme activity in the different levels, and enzyme activity of these sections changed depending on time post-feeding.
Konsep Pelayanan Publik Pada Masa Adaptasi Kebiasaan Baru (New Normal) Pandemi Covid-19 Ditinjau Dari Perspektif Regulasi
Authors: Putri Ayu Endang , Nuriyatman Eko
Published: May 2022

Pelayanan publik adalah pemberian pelayanan atau melayani keperluan orang (masyarakat) yang mempunyai kepentingan sesuai dengan peraturan perundang-undangan yang berlaku dan tata cara yang telah ditetapkan. Penyelenggaraan pelayanan publik dilaksanakan oleh pemerintah sesuai dengan peraturan perundang-undangan dan instrumen regulasi yang berlaku. Artikel ini akan membahas bagaimana regulasi tentang  penyelenggaraan pelayanan publik pada masa pandemi Covid-19 diera new normal. penulisan artikel ini menggunakan metode penelitian yuridis normatif dengan menelaah peraturan perundang-undangan yang berkaitan dengan permasalahan yang sedang diamati. Kesimpulan dari artikel ini yaitu: Pertama, komponen standar pelayanan publik yang terdapat pada UU No. 25 Tahun 2009 tentang Pelayanan Publik harus dapat disesuaikan dengan kondisi new normal. kedua, pemerintah daerah harus menindaklanjuti keputusan pemerintah tingkat pusat yang menyangkut penyelenggaraan pelayanan publik diera new normal sebagai pedoman penyelenggaraan pelayanan publik di daerah masing-masing.
PELAKSANAAN FUNGSI PENYIARAN SEBAGAI IMPLEMENTASI KETERBUKAAN INFORMASI PUBLIK DI MASA PANDEMI COVID-19 OLEH TVRI STASIUN JAMBI
Authors: Arita Zaky , Rahmi Elita , Fitria Fitria
Published: May 2022

Penelitian ini bertujuan untuk mengetahui dan menganalisis bentuk dari pelaksanaan fungsi penyiaran sebgai implementasi keterbukaan informasi publik dalam penangan dan pencegahan COVID-19 di TVRI Stasiun Jambi. Metode penelitian yang digunakan dalam penelitian ini adalah yuridis empiris, yaitu suatu penelitian yang menujukkan adanya kesenjangan antara das sollen dan das sein (harapan dan kenyataan). Hasil dari penelitian ini adalah pelaksanaan keterbukaan informasi merupakan sebuah kewajiban bagi pemerintah, melalui TVRI Stasiun Jambi diharapkan pemerintah dapat memberikan keterbukaan informasi yang sudah diatur di dalam Undang-Undang Nomor 14 Tahun 2008 Tentang Keterbukaan Informasi. Di tengah pandemic COVID-19 yang melanda dunia termasuk Indonesia terkhusus Provinsi Jambi keterbukaan informasi merupakan sarana perwujudan good governance, keterbukaan informasi merupakan salah satu upaya penangan COVID-19 yang dapat dilakukan oleh pemerintah, melalu TVRI Stasiun Jambi pemerintah diharapkan dapat melakukan sosialisai terkait pencegahan penularan COVID-19 untuk mewujudkan keterbukaan informasi.
Keterbukaan Informasi Publik Dalam Pelayanan Administrasi Kependudukan Pada Dinas Kependudukan Dan Catatan Sipin Kota Jambi
Authors: Zulkarnain Iskandar , Zalia Maghfira Alissa
Published: May 2022

ABSTRAK

 

Penelitian ini bertujuan untuk mengetahui dan menganalisis mengenai keterbukaan informasi publik dalam pelayanan administrasi kependudukan pada Dinas Kependudukan dan Catatan Sipil Kota Jambi . Manfaat penulisan untuk memberikan pengetahuan tentang peran Dinas Kependudukan dan Catatan Sipil Kota Jambi mengenai kendala yg dialami terkait keterbukaan informasi publik dalam pelayanan administrasi kependudukan dan telah diatur dalam undang-undang nomor 14 tahun 2008 tentang keterbukaan informasi publik . Metode penelitian ini merupakan penelitian yuridis empiris sebagai dukungan data yang digunakan yaitu dari data skunder dan data primer dikumpulkan melalui keperpustakaan dan penelitian lapangan . Dari hasil penelitian dapat disimpulkan bahwa pemerintah Dinas Kependudukan dan Catatan Sipil Kota Jambi dalam menjalankan peran nya harus berdasarkan tugas dan fungsinya masih terdapat beberapa kendala yaitu karena adanya faktor seperti keluhan masyarakat tentang  permasalahan proses pembuatan produk layanan seperti akta kelahiran , KK , dan KTP Elektronik menjadi tidak optimal nya informasi yg diterima oleh masyarakat dan lama pembuatan nya memperlihatkan bahwa petugas Dinas Kependudukan dan Pencatatan Sipil Kota Jambi belum memberikan informasi yg jelas dan menyeluruh kepada masyarakat Kota Jambi.
Kualitas Pelayanan Pembuatan Surat Izin Mengemudi Dalam Penyelenggaraan Pelayanan Publik Di Kota Jambi
Authors: Yuhana Ersa , Budhiartie Arrie , Nuriyatman Eko
Published: May 2022

Penulisan artikel ini bertujuan untuk memaparkan tentang kualitas pelayanan pembuatan Surat Izin Mengemudi dalam penyelenggaraan pelayanan publik yang sering terjadi di berbagai daerah di Indonesia. Penelitian ini menggunakan metode Yuridis Empiris dan menggunakan data primer dan data sekunder dengan pendekatan analisis deskriptif. Adapun yang menjadi latar belakang penulisan ini terjadi dikarenakan masih banyak di temukannya pelayanan yang kurang maksimal dan bahkan masih banyak terdapat penyimpangan-penyimpangan yang di lakukan baik petugas itu sendiri maupun oleh masyarakatnya. Meskipun pemerintah telah merancang peraturan perundang-undangan terkait prosedur yang harus di taati oleh semua pihak, namun ternyata hal tersebut belum mampu mengatasi masalah yang terjadi. Beberapa permasalahan tersebut di sebabkan karena minimnya pengawasan, kurang ketatnya sistem pengendalian kinerja petugas dan lain sebagainya. Salah satu upaya yang dapat dilakukan yaitu dengan meningkatkan peran pemerintah dalam mengawasi penyelenggaraan pelayanan publik di bidang pembuatan Surat Izin Mengemudi serta didukung dengan cara menerapkan asas transparansi agar sistem dan prosedur penyelenggaraan pelayanan tersebut dapat di ketahui oleh seluruh lapisan masyarakat.
Implementasi Pengaturan Tata Ruang Kota Melalui Penerapan Izin Mendirikan Bangunan di Kota Jambi
Authors: Khairiyyah Annisa , Amir Latifah
Published: May 2022

Tulisan ini berjudul Implementasi Pengaturan Tata Ruang Kota Melalui Penerapan Izin Mendirikan Bangunan Di Kota Jambi. Adapun yang melatarbelakangi tulisan ini adalah beberapa permasalahan yakni pertama, penyimpangan tata ruang seperti pelanggaran tata ruang yang terjadi  di Kota Jambi salah satunya yaitu bangunan permanen yang berdiri tanpa Izin seperti Bangunan Rumah Sakit Rimbo Medika di Jalan Pattimura Simpang Rimbo Kota Jambi, yang dibangun tanpa mengantongi izin mendirikan bangunan. Selain itu dukungan terhadap pengembangan wilayah yang belum optimal. Oleh karena itu harus ada pengaturan lebih lanjut tentang Rencana Tata Ruang Wilayah Kota Jambi.   Serta dibutuhkan suatu komitmen dari Pemerintah Kota Jambi untuk mengatasi masalah-masalah tersebut dengan salah satunya melalui  peraturan daerah (Perda) yang mengatur fungsi tata ruang Kota Jambi. Permasalahan yang diangkat dalam penelitian ini antara lain tentang bagaimana bagaimana implementasi rencana tata ruang wilayah Kota Jambi yang dikonsepsikan melalui perizinan bangunan? Dan kedua bagaimana pengaturan pelaksanaanya berdasarkan peraturan perundang-undangan yang berlaku? Metode yang digunakan dalam tulisan ini adalah penelitian hukum normatif.
Penegakan Sanksi Dalam Penataan Ruang Guna Mewujudkan Pembangunan Yang Berkelanjutan Di Indonesia
Authors: Sri Rahayu Yunita , Hasimi Sri Ningsih , Zulkarnain Iskandar
Published: May 2022

Penegakan hukum dalam pelanggaran penaatan ruang merupakan hal yang sangat penting. Masalah yang sering kali ditemukan dalam rencana tata ruang ialah pada proses penegakan hukumnya, hal itu disebabkan oleh banyaknya pelanggaran-pelanggaran terhadap suatu penataan ruang yang dibiarkan begitu saja. Permasalahan dalam penelitian ini adalah bagaimana penegakan hukum tata ruang di Indonesia saat inidan bagaimana caranya mewujudkan penataan ruang yang berkelanjutan. Untuk mengkaji permasalahan yang ada, maka dalam penelitian ini menggunakan metode penelitian normatif. Hasil penelitian ini menyimpulkan bahwa berdasarkan UU PenataanRuang belum optimal dalam meminimalisir pelanggaran penataan ruang dikarenakan adanya potensi konflik antar wilayah, antarsektor, danantara masyarakat dengan pemerintah. Di sisi lain lemahnya penegakan hukum lingkungan serta kecenderungan sanksi yang ringan tidak menimbulkan efek penjeraan terhadap pelaku pelanggaran penaataan ruang, sehingga menyebabkan permasalahan terkait penataan ruang dan penegakan hukum nya tidak berjalan efektif. Seharusnya hokum lingkungan bekerja di dalam menyelamatkan, melindungi, melestarikan lingkungan hidup dan melindungi keberlangsungan kehidupan umat manusia dari kemungkinan kerusakan lingkungan hidup. Oleh karena itu perlunya pengaturan penataan ruang demi terwujudnya ketertiban dalam penyelenggaraan penataan ruang, adanya kepastian hokum dan keadilan bagi seluruh pemangku kepentingan yang harus dilakukan secara cermat, proporsional, dan komprehensip sehingga terwujud pembangunan yang berkelanjutan.
Modelo para asesorías interuniversitarias, basado en la propuesta de mediación pedagógica de Gutiérrez y Prieto
Authors: Peraza-Delgado Mercedes , Barboza-Robles Yansin
Published: May 2022

Este artículo presenta la experiencia de implementación de un modelo para la formación profesional superior basado en la propuesta teórica de mediación pedagógica de Gutiérrez y Prieto, en el Taller “Fundamentos de la producción de materiales didácticos escritos en un sistema de educación a distancia”. El propósito de la experiencia es promover el aprendizaje de adultos con una metodología participativa, en un ambiente dinámico y práctico. El modelo se valida en el 2018 con un grupo de 30 académicos de la Universidad de El Salvador (UES) con resultados positivos: se comprueba la utilidad de las secciones iniciales incluidas en el taller para motivar la participación, así como la utilidad para el aprendizaje de los temas y actividades del taller en la consecución de los objetivos.
Percepción de estudiantes universitarios acerca de la presencialidad en el aula y presencialidad remota durante la pandemia del COVID-19
Authors: Salas-Cabrera Jorge , Rojas-Garbanzo Marianela , Rojas-Valverde Daniel , Anchía-Umaña Irina
Published: May 2022

Este estudio cumple como propósito obtener la percepción del estudiantado de grado y posgrado de las carreras en ciencias del movimiento humano, acerca de la enseñanza, aprendizaje y la evaluación durante la pandemia COVID-19 relacionada con el virus SARS-CoV-2. En este estudio participan de manera voluntaria un total de 23 estudiantes (12 grado y 11 estudiantes de posgrado) con edades entre los 19 años y los 45 años. Con el fin de obtener el consentimiento informado de participación, se contacta al estudiantado por diferentes medios virtuales como redes sociales. Una vez se obtuvo la muestra a participar en la investigación, se procede enviar por correo electrónico el debido consentimiento y la entrevista semi estructurada para que sean completadas por las personas participantes. Esta entrevista fue diseñada por el investigador principal y analizada por criterio de expertos en pedagogía. Una vez que se obtuvo las respuestas se procede a sistematizarlas utilizando conglomerados según similitud temática para su análisis. Los resultados muestran que los estudiantes perciben un aprendizaje más significativo cuando están presentes en el aula. Adicionalmente, rescatan que la presencialidad remota facilita un mayor aprovechamiento del tiempo y recurso y rescatan su pertinencia en cursos con un alto componente teórico. Además, consideran que las evaluaciones deben enfocarse en la asignación de prácticas investigativas y no en la realización pruebas memorísticas. Con base en los resultados, se concluye que ante la eventualidad de la pandemia COVID-19, el estudiantado considera que la metodología de presencialidad remota puede ser una opción potencial para el desarrollo de componente teórico y utilizar las horas contacto presencial para el desarrollo de prácticas que le permitan vivenciar y poner en práctica su aprendizaje.
Synthesis of a novel polycerasoidol analogue with pan-PPAR agonism: anti-inflammatory effects and improvement of metabolic derangements in ob/ob mice
Authors: Marques Patrice , Villarroel Carlos , Collado Aida , Garcia Ainoha , Vila Laura , Duplan Isabelle , Hennuyer Nathalie , Garibotto Francisco , Enriz Ricardo , Dacquet Catherine , Staels Bart , Cortes Diego , Sanz Maria-Jesus , Cabedo Nuria
Published: May 2022

Background and Purpose: Selective peroxisome proliferator-activated
receptors (PPARs) are widely used to treat metabolic complications;
however, the limited effect of PPARα agonists on glucose metabolism and
the adverse effects associated with selective PPARγ activators have
stimulated the development of novel pan-PPAR agonists to treat metabolic
disorders. Here, we synthesised a new prenylated benzopyran (BP-2) and
evaluated its PPAR-activating properties, anti-inflammatory effects and
impact on metabolic derangements. Experimental Approach: BP-2 was used
in transactivation assays to evaluate its agonism to PPARα, PPARβ/δ and
PPARγ. A parallel-plate flow chamber was employed to investigate its
effects on TNFα-induced leucocyte-endothelium interactions, and flow
cytometry and immunofluorescence were used to determine its effects on
the expression of endothelial cell adhesion molecules (CAMs) and
chemokines and p38-MAPK/NF-κB activation. PPARs/RXRα interactions were
determined using a gene silencing approach. Analysis of its impact on
metabolic abnormalities and inflammation was performed in ob/ob mice.
Key Results: BP-2 displayed strong PPARα activity, with moderate and
weak activity against PPARβ/δ and PPARγ activity, respectfully. In
vitro, BP-2 reduced TNFα-induced endothelial ICAM-1, VCAM-1 and
fractalkine/CX3CL1 expression, suppressed mononuclear cell arrest via
PPARβ/δ-RXRα interactions and decreased p38-MAPK/NF-κB activation. In
vivo, BP-2 improved the circulating levels of glucose and triglycerides
in ob/ob mice, suppressed T-lymphocyte/macrophage infiltration and
proinflammatory markers in the liver and white adipose tissue, but
increased the expression of the M2-like macrophage marker CD206.
Conclusion and Implications: BP-2 emerges as a novel pan-PPAR lead
candidate to normalise glycaemia/triglyceridaemia and minimise
inflammation in metabolic disorders, likely preventing the development
of further cardiovascular complications.
OPTIMIZATION OF TOPICAL RAPAMYCIN: CHEMICAL, PHYSICAL AND MICROBIOLOGICAL STABILITY
Authors: Cortell-Fuster Clara , Martínez-Gómez María Amparo , Cercós-Lleti Ana Cristina , Climente-Martí Mónica
Published: May 2022

Introduction: topical rapamycin has been established as an effective and
safe therapy for facial angiofibromas in tuberous sclerosis. Different
formulations have been tested for this skin disease, most using an
ointment as a vehicle. Purpose: to improve the classical formulation of
topical rapamycin and to determine the validity period of the proposed
options based on chemical, physical and microbiological stability
studies. Methods: four different 0.4% rapamycin formulations were
prepared (ointment, emulsion, gel and liposomes). The stability studies
for each formulation were: chemical (extraction with lipophilic solvents
and high-performance liquid chromatography assay), physical (pH,
uniformity, extensibility, absence of crystals, absence of phase
separation and only for liposomal formulation was determined particle
size, zeta potential and encapsulation efficiency) and microbiological
(culture samples in blood-agar media) during 56 days. Results: only
liposomes were chemically, physically and microbiologically stable after
8 weeks. Ointment, emulsion and gel formulations lost their chemical and
physical stability before 56 days. Conclusions: this study describes a
new four formulations to improve the previously treatment for facial
angiofibromas in tuberous sclerosis. It also provides favorable
stability data only for liposomes. However, more dermokinetic and
clinical studies are needed to confirm that liposomes are most
appropriate to ensure effectiveness, safety and high patient
satisfaction.
Stability and Bifurcation analysis of SIR Model with Virus Mutation using Delay Differential Equation
Authors: kumar pankaj , Singh Raminder Pal
Published: May 2022

A mathematical examination of the SIR model under mutation is presented
in this paper, by integrating an incubation time lag and a general
nonlinear incidence rate. When the virus mutates, the recovered
population loss its immunity. A time lag gives for a grace period before
people become vulnerable once more. At the rate ‘c,’ they become
vulnerable, which is the recovery rate, depending upon their status at
(t-τau). The three-state variable are S (Susceptible population), I
(Infected population) and R (Recovered population). A non-zero
equilibrium point has been found. Stability and Directional analysis are
performed about this non zero equilibrium. Hopf-Bifurcation occurred
when the delay parameter τ goes beyond a critical point value.
Sensitivity analysis is performed by using direct method and Directional
analysis is performed by using K. R. Schneider, ‘Hassard, B. D.
[22]. Numerical simulation is done to support analytical results
using MATLAB.
“Aceclofenac Induced Toxic Epidermal Necrolysis: A Rare Case Report”
Authors: Singh Atmik , Pore Shraddha , Khade Asha , Sharma Mallika
Published: May 2022

Toxic Epidermal Necrolysis (TEN) is potentially life threatening
cutaneous disorder usually induced by drugs. Non steroidal
anti-inflammatory drugs (NSAIDS) are one of the common groups implicated
in drug induced TEN. Aceclofenac is a relatively new NSAID exhibiting
preferential cyclooxygenase-2 inhibition. It is widely used in
management of musculoskeletal disorders. This report describes TEN
induced by aceclofenac in a 58 year old female who self medicated
herself with higher dose of aceclofenac for knee joint pain.
A joint weighted power detector for Willie in two-hop covert communication system
Authors: Wan Zehan , Huang Ying , Lei Jing , Lai Ke , Huang Luying
Published: May 2022

In this letter, a joint weighted power detector (JWPD) based on maximum
a posterior probability (MAP) criteria is proposed for Willie aiming at
two-hop covert communication scenario, which is a near optimal detector.
Instead of only supervising one single phase, Willie combines the
observations of two phases to make joint decision in the proposed
scheme. The proposed scheme achieves lower probability of detection
error (PDE) than the existing single-phase-detector (SPD) scheme and
adding-power-directly-detector (APDD) scheme due to sufficient
utilization of the two-phases observations. Numerical results
demonstrate the benefit of our proposed scheme.
UHI in Fortaleza and trends on screen-level air temperature and humidity
Authors: Afrânio Coelho,
Published: May 2022

This is a generic template designed for submission
to Wiley Journals. Please consult your specific journal’s
author guidelines in order to confirm that your manuscript complies with
the journal’s requirements. Please replace this text with your abstract.

Keywords — keyword 1, keyword 2, keyword 3, keyword 4,
keyword 5, keyword 6, keyword 7
Editor’s response to “An Oversight Regarding the Club Cell?”
Authors: McColley Susanna
Published: May 2022

Pediatric Pulmonology strives to uphold the strongest ethical standards
in publishing and to serve our diverse, international community of
authors and readers with respect. We will be vigilant to prevent
recurrence of this and other out-of-date, harmful terminology.
Coliforms and antibiotic-resistant bacteria in water from rivers and wells at Curitibanos, Santa Catarina
Authors: Ribeiro Gabrielle França , Angelo Natalia Maria Martinazzo , Proença Júlia Elizabeth , Da Cruz Sonia Purin
Published: May 2022

The quality of water used for human consumption related to the absence of coliforms, which, which may cause diseases and exhibit antimicrobial resistance, a frequent issue in places with poor or non-existent environmental sanitation. The present study evaluated the concentrations of total and thermotolerant coliforms in rivers and wells in Curitibanos (SC), as well as the phenotypic resistance to four antibiotics (Ampicillin, Ampicillin+Sulbactam, Ciprofloxacin and Tetracycline), during four seasons of the year. Analysis of variance was performed and means were separated by the Scott-Knott test, at 5% error probability. In rivers, the highest values ​​of fecal coliforms were recorded in summer and winter, and resistance to ampicillin and ampicillin+sulbactam was higher in autumn, while resistance to tetracycline was more prevalent in summer. In the wells, the highest averages of fecal coliforms occurred in summer, autumn and winter, and the highest levels of resistance were observed against ampicillin, in autumn. Overall, rivers had more compromised water quality, compared to wells, emphasizing the need to preserve aquatic resources in order to decrease evolution of resistance to antibiotics and diseases and deaths cause by superbacteria that may be ingested with contaminated water.
1-LB: Trends in Incidence and Age at Diagnosis of Youth-Onset Type 2 Diabetes, 2002–2018—The SEARCH for Diabetes in Youth Study
Authors: SAUDER KATHERINE A. , WAGENKNECHT LYNNE E. , LIESE ANGELA D. , DABELEA DANA , MARCOVINA SANTICA M. , PIHOKER CATHERINE , REYNOLDS KRISTI , SHAH AMY S. , DOLAN LAWRENCE M. , BELLATORRE ANNA , LAWRENCE JEAN M. , DIVERS JASMIN , JENSEN ELIZABETH T.
Published: May 2022

The SEARCH study ascertained individuals with type 2 diabetes (T2D) diagnosed at <20 years of age at 5 study centers in the US from 2002 to 2018 and calculated annual incidence as number of cases divided by the population <20 years in the catchment area (∼5 million annually based on US Census or health-plan member counts) . We estimated incidence trends using a generalized autoregressive (2-year) moving average model. From annual incidence, we calculated peak age at T2D diagnosis overall population and within period, sex, race and ethnicity strata. Incidence increased from 2002-2009 to 2010-2018 (p<0.0001) ; however, the peak age at diagnosis did not change (16 years; Figure) . Across all years, the peak age at diagnosis was similar between females (16 years [95% CI 15-18]) and males (16 years [16-18]) . The peak age at diagnosis was younger for non-Hispanic Black youth (NHB; 13 years) , while similar for American Indian (AI) , Asian and Pacific Islander (API) , Hispanic (HISP) , and non-Hispanic White (NHW) youth (16 years; Figure) . These data indicate continued increases in T2D incidence across ages associated with the pubertal transition, with a rapid decline following the incidence peak. They also highlight an earlier T2D onset among NHB youth. These results highlight the need for pre-pubertal or early pubertal intervention to mitigate risk of youth-onset T2D.

Disclosure

K. A. Sauder: None. A. Bellatorre: None. J. M. Lawrence: None. J. Divers: None. E. T. Jensen: Consultant; Regeneron Pharmaceuticals Inc. L. E. Wagenknecht: None. A. D. Liese: None. D. Dabelea: None. S. M. Marcovina: None. C. Pihoker: None. K. Reynolds: Research Support; Amgen Inc., Merck & Co., Inc., Novartis Pharmaceuticals Corporation. A. S. Shah: None. L. M. Dolan: None.

Funding

Centers for Disease Control and Prevention and National Institutes of Health
1-OR: A Unique Adipocyte Progenitor Population Promotes Age-Related Adiposity
Authors: WANG QIONG (ANNABEL) , JIANG LEI , YANG XIA , WANG GUAN , LI GAOYAN
Published: May 2022

The average fat mass in adults increases dramatically with age, and older people often suffer from visceral obesity and related adverse metabolic disorders. Unfortunately, how aging leads to fat accumulation is poorly understood. It is known that fat cell (adipocyte) turnover is very low in young mice, similar to that in young humans. Here, we find that mice mimic age-related fat expansion in humans. In vivo lineage tracing shows that massive adipogenesis (the generation of new adipocytes) , especially in the visceral fat, is triggered during aging. Thus, in contrast to most types of adult stem cells that exhibit a reduced ability to proliferate and differentiate, the adipogenic potential of adipocyte progenitor cells (APCs) is unlocked by aging. In vivo transplantation and 3D imaging of transplants show that APCs in aged mice cell-autonomously gain high adipogenic capacity. Single-cell RNA sequencing analyses reveal that aging globally remodels APCs. Herein, we identify a novel committed preadipocyte population that is age-specific (CP-A) , existing both in mice and humans, with a global activation of proliferation and adipogenesis pathways. CP-A cells display high proliferation and adipogenesis activity, both in vivo and in vitro. LIFR serves as a functional maker of CP-A, which promotes CP-A proliferation. Together, these findings define a new fundamental mechanism involved in fat tissue aging and offer prospects for preventing and treating age-related metabolic disorders.

Disclosure

Q.Wang: None. L.Jiang: None. X.Yang: None. G.Wang: None. G.Li: None.

Funding

American Diabetes Association (1-19-JDF-023) ; National Institutes of Health R01AG063854, R01HD096152, and R01DK128907
1009-P: The Association between Patient Characteristics and the Efficacy of Remote Patient Monitoring and Messaging
Authors: FERSTAD JOHANNES , PRAHALAD PRIYA , MAAHS DAVID M. , FOX EMILY , JOHARI RAMESH , SCHEINKER DAVID
Published: May 2022

In the Pilot 4T study (n=135) , remote patient monitoring (RPM) was associated with improved time in range (TIR) and lower A1c. Measuring differences in how patients respond to messages from the care team is essential for the design of effective, personalized care models. We analyzed electronic health record (EHR) and continuous glucose monitor (CGM) data to estimate the week-over-week impact of RPM messages on patients’ TIR. We applied statistical clustering methods to divide patients who received messages into two groups based on their changes in TIR and compared the characteristics of these groups. Receiving a message was associated with a greater mean week-to-week improvement in TIR after a low-TIR week [4.9 percentage points (pp) after a message vs. 2.5pp without a message; p < 0.001]. A patient’s TIR improvement after receiving a message is greater on average if the same patient’s TIR improved following previous messages. We identified two groups of patients with significantly different responses to messages. The group with greater mean TIR improvement after messages contains a larger proportion of non-white, non-English speaking, and publicly insured patients. We found that messages were associated with different magnitudes of TIR improvement across two clusters of patients. Identifying patients who benefit more from RPM could facilitate the personalization of management strategies.

Disclosure

J.Ferstad: None. P.Prahalad: None. D.M.Maahs: Advisory Panel; Abbott Diabetes, Eli Lilly and Company, Medtronic, Novo Nordisk, Sanofi, Consultant; Aditx Therapeutics, Inc., Biospex. E.Fox: None. R.Johari: None. D.Scheinker: None.

Funding

Helmsley Charitable Trust, ISPAD-JDRF Fellowship,NIH R18DK122422,Stanford Diabetes Research Center,LPCH Auxiliaries,Stanford Maternal and Child Health Research Institute, The Stanford REDCap platform (http://redcap.stanford.edu) is developed and operated by Stanford Medicine Research IT team. The REDCap platform services at Stanford are subsidized by a) Stanford School of Medicine Research Office, and b) the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through grant UL1 TR001085.
1014-P: Characteristics Associated with Diabetes Device Use Before and During the Pandemic in Youth with T1D
Authors: CHEN CHARLOTTE , ADAM ATIF , OJUKWU SANDO , KAUSHAL TARA , TINSLEY LIANE J. , VOLKENING LISA K. , LAFFEL LORI M.
Published: May 2022

Introduction: The impact of the Covid-pandemic on diabetes device uptake and use in youth with T1D is unclear. We assessed demographic, diabetes, and SES characteristics associated with diabetes technology (pump, CGM) use in youth with T1D, aged ≤18 years, pre- and during the pandemic.

Methods: EHR provided ∼18 months of data pre- and during the pandemic. Pump and CGM use were defined as device use at ≥50% of visits. Geocoding provided census tract-specific SES measures from the 20American Community Survey. Logistic regression models analyzed the probability of device use vs. non-use in the pre- and pandemic periods by geocoded SES status, adjusted for age, gender, baseline A1c, and T1D duration.

Results: Pre-pandemic sample had 734 youth (male 49%, aged 13.8±3.3 years, T1D duration 7.3±3.4 years) ; pandemic sample had 800 youth (male 51%, aged 13.4±3.7 years, T1D duration 6.6±3.9 years) ; 689 were in both periods. Pre- and during pandemic, respectively, there were 25% and 22% device non-users; 19% and 21% pump only; 13% and 16% CGM only; 43% and 41% both. Pre-pandemic baseline A1c differed by the 4 device use groups: non-users 9.1±1.7%; pump 8.5±1.2%; CGM 8.2±1.2%; both 8.1±1.0%; p<.05.In both periods, the odds of device non-users starting a device were reduced in those from low-income tracts (≤$40,000) (pre: OR 0.60, 95%CI 0.40-0.91; during: OR 0.59, 95%CI 0.39-0.88; respectively, both p=.01) and low education tracts (≥30% high school or less) (pre: OR 0.57, 95%CI 0.39-0.85; during: OR 0.65, 95%CI 0.44-0.97; both p≤.03) . While the odds of CGM uptake were significantly reduced by ∼40% in presence of unfavorable census SES factors (p≤.01) , the odds of pump start were not (p≥.05) . Odds of uptake of both devices were significantly reduced by ∼45% in presence of unfavorable census SES factors (p≤.02) in both periods.

Conclusion: During the pandemic, there remained decreased uptake and less continued use of diabetes device in lower SES patients. Further work is needed to decrease the inequality gap.

Disclosure

C.Chen: None. A.Adam: None. S.Ojukwu: None. T.Kaushal: None. L.J.Tinsley: None. L.K.Volkening: None. L.M.Laffel: Advisory Panel; Medtronic, Roche Diabetes Care, Consultant; Boehringer Ingelheim International GmbH, Dexcom, Inc., Dompé, Insulet Corporation, Janssen Pharmaceuticals, Inc., Lilly Diabetes, Novo Nordisk, Provention Bio, Inc.

Funding

National Institutes of Health (P30DK036836,T32DK007260)
1023-P: Clusters of Depressive Symptoms and Glycemic Outcomes in Youth with Type 1 Diabetes (T1D)
Authors: SHAPIRA AMIT , VOLKENING LISA K. , LAFFEL LORI M.
Published: May 2022

Aim: Depression is a heterogeneous construct that includes various symptoms (e.g., cognitive, somatic) and is linked to worse diabetes outcomes. We examined the associations of depressive symptom clusters with glycemic outcomes using continuous glucose monitoring (CGM) data in youth with T1D.

Methods: Participants (N=120) provided blood samples for HbA1c, completed a validated survey for depressive symptoms (CES-DC) , and wore CGM for one week. CGM glucose metrics were derived: % time in range (TIR) 70-180 mg/dL; % time <70 mg/dL; % time >180 mg/dL; % time >250 mg/dL; mean glucose; and glucose variability (GCV) . CES-DC items were categorized as somatic, cognitive, anhedonic, and interpersonal for analyses.

Results: Youth (49% male) had a mean (±SD) age of 12.7±2.7 years, T1D duration 6.1±3.5 years, HbA1c 7.9±0.8%. Overall, higher total CES-DC score was associated with higher HbA1c (r=0.21, p=0.02) . In youth with HbA1c ≤8% (n=68) , there were no significant associations between depressive clusters and glycemic outcomes, but several significant associations emerged in youth with HbA1c >8% (n=52) . For those with HbA1c >8%, higher CES-DC total score was associated with higher HbA1c (r=0.55, p<0.0001) , greater % time >250 (r=0.29, p=0.03) , and higher mean glucose (r=0.33, p=0.02) . More symptoms on the cognitive and interpersonal clusters were associated with higher HbA1c (r=0.29, p=0.03; r=0.43, p=0.002, respectively) . More somatic symptoms were associated with greater % time >180 (r=0.34, p=0.01) , less % TIR (r=-0.34, p=0.01) , and higher mean glucose (r=0.31, p=0.03) .

Conclusions: In our sample of youth with T1D, associations between depressive symptoms and glucose varied according to overall glycemic control, with notable associations in youth with HbA1c >8%. Somatic depressive symptoms were especially related to uncontrolled glucose levels, highlighting the importance of targeting glucose TIR to reduce adverse physical complaints.

Disclosure

A.Shapira: None. L.K.Volkening: None. L.M.Laffel: Advisory Panel; Medtronic, Roche Diabetes Care, Consultant; Boehringer Ingelheim International GmbH, Dexcom, Inc., Dompé, Insulet Corporation, Janssen Pharmaceuticals, Inc., Lilly Diabetes, Novo Nordisk, Provention Bio, Inc.

Funding

T32DK007260, P30DK036836, R01DK089349
1026-P: Retrospective Analysis of Caregiver Health Management Competence during an Occupation Therapy Coaching Telehealth Intervention
Authors: SHIN JULIA , JEWELL VANESSA D. , QI YONGYUE , VALDEZ ANDREA D.
Published: May 2022

Occupation-based coaching is a collaborative, family-centered intervention which can empower caregivers of children with type 1 diabetes to establish independence with diabetes management. A RCT involving telehealth occupation-based coaching intervention was piloted with rural-dwelling caregivers with a child (2-12 years) diagnosed with type 1 diabetes. Ten caregivers received 1-hour weekly sessions across 12 weeks, which were digitally recorded and transcribed verbatim. Of the 12 sessions, two sessions/transcripts were randomly selected from each of the beginning, middle, and end phases per family. The average word count and rating at each phase were calculated and repeated measures ANOVA were used to evaluate how problem-solving progressed during the coaching sessions. Analyzing a total of 60 transcripts/sessions, we found that the percentage of parent mean word count increased significantly from 67.2 at the beginning to 67.9 at middle phase and then increased to 72.4 at the end (p=0.034) demonstrating a significant linear trend (p=0.019) . The percentage of interventionist word count significantly decreased from beginning to end phases (beginning: Mean=32.8, SD=15.0; middle: Mean=32.1, SD=17.8; end: Mean=27.6, SD=12.9, p=0.034) and showed significant linear trend (p=0.019) . Average rating on the Evidence of Independent Capacity Rating Scale where “A” indicates high level of independence and “C” indicates low level of independence from the interventionist improved significantly from a rating close to B and rating of B at the beginning and middle phases, respectively, and continued to improve to a rating close to A at the end phrase (p<0.001) ; significant linear trend of improvement was also noted (p<0.001) . Preliminary evidence suggests that occupation-based coaching supports rural-dwelling families to develop problem-solving skills and autonomy in caring for their child diagnosed with type 1 diabetes.

Disclosure

J.Shin: Research Support; Dexcom, Inc. V.D.Jewell: Research Support; Dexcom, Inc. Y.Qi: Research Support; Dexcom, Inc. A.D.Valdez: None.

Funding

Health Science Strategic Investment Faculty Development Grant, Creighton University
1027-P: Access to Telemedicine and the Number of Medical Visits Pre- and Post-Lockdown in Latin American Children with Type 1 Diabetes
Authors: HIRSCHLER VALERIA , PELICAND JULIE , SOBRERO ANGELA M. FIGUEROA , GONZALEZ DIANA S. , SCAIOLA EDIT R. , BOCCO PATRICIA , IBARCENA PAOLA M. PINTO , DEL AGUILA CARLOS M. , TRILLO CAROLINA ANDREA RAMIREZ , MAC AILÍN I. , LAPERTOSA SILIVA , MOLINARI CLAUDIA
Published: May 2022

Objective: To compare the number of medical visits during the 2020 lockdown with the previous two years (2018, 2019) and with post-lockdown (2021) in Latin American children with type 1 diabetes (T1DM) with and without telemedicine access.

Methods: Children with T1DM in 2018 from three Latin American countries and at least one consultation in 2018 were consecutively recruited between February and November 2021. The number of medical visits and telemedicine access were extracted from their medical records.

Results: 217 children (60.4% females) aged 13.1± 3.2 years with a duration of 6.1 ± 2.7 years of T1DM were evaluated. There was a higher prevalence of children with telemedicine access than those without (139 (64.1%) vs. 78 (35.9%) ; p<0.01) . The number of medical visits was significantly higher in children with than without telemedicine access in lockdown 2020 (7.02 vs. 2.61, respectively) and post-lockdown 2021 (5.36 vs. 1.91) . The number of medical visits during post-lockdown 2021 (5.33) was not significantly different than in 2018 (5.13) in those with telemedicine access. However, the number was significantly lower in those without access (1.91 in 2021 vs. 5.99 in 2018) .

Conclusion: the number of medical visits of Latin American children during post-lockdown returned to a similar number to pre-lockdown 2018 in children with telemedicine access, but not in those without access.

Disclosure

A.M. Figueroa Sobrero: None. D.S. Gonzalez: None. E.R. Scaiola: None. P. Bocco: None. P.M. Pinto Ibarcena: None. C.M. Del Aguila: None. A.I. Mac: None. S. Lapertosa: None.
103-LB: Comparison of Two Hyperglycemia Correction Scales in Hospitalized Patients with Diabetes Mellitus Type 2—CAPADOCIA 2 Trial
Authors: YEPES CARLOS A. , MORA JAVIER M. , MOSCOSO EVELYN , RODRÍGUEZ JORGE ALEJANDRO R. , LEÓN LAURA A. , GOMEZ JAVIER , BURITICÁ NATHALIE
Published: May 2022

Introduction: We evaluated the efficacy and safety of the recommended scheme by international guideline in 2012 (2012’s scheme) in comparison with a less aggressive scheme (2019’s scheme) proposed by Umpierrez et al.

Methods: A non-blinded randomized clinical study was conducted in which two short-time insulin schemes for hyperglycemic control (2012’s vs. 2019’s) were compared in hospitalized patients of Hospital Universitario Clínica San Rafael (HUCSR) in Bogotá Colombia in a period between october 2019 and february 2022.

Results: Totally, 91 patients joined the trial. There were no statically significant difference between the demographic characteristics and outcomes.

Conclusions: The two schemes are equally safe and efficient in our population and can be used interchangeably.

Disclosure

C. A. Yepes: Speaker’s Bureau; Medtronic, Novo Nordisk, Sanofi. J. M. Mora: None. E. Moscoso: None. J. R. Rodríguez: None. L. A. León: None. J. Gomez: None. N. Buriticá: None.
1030-P: Glycemic Control Two Years after Diagnosis in Children with Type 1 Diabetes In Kuwait
Authors: ALQAISI TAIBAH , ALSABER AHMAD R. , ALKANDARI HESSA , AL-ABDULRAZZAQ DALIA
Published: May 2022

Type 1 diabetes (T1D) in children is linked to a high risk of developing microvascular and macrovascular complications. HbA1c is an indicator for assessing long-term glycemic outcomes and a modifiable risk factor directly related to diabetes complications. The study aim was to describe glycemic outcomes of children with T1D at baseline and over a 2-year follow-up period post diagnosis as well as identify factors associated with optimal glycemic control. This retrospective cross-sectional study included patients (aged ≤14) with T1D registered in the Childhood Onset Diabetes electronic Registry (CODeR) between 2011-2017. Baseline data was retrieved through CODeR and follow-up data was retrieved by medical chart review. Optimal glycemic control was defined as HbA1c <7.5% per the International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines at the follow-up period. ANOVA, chi-square, and logistics regression analysis was used. A total of 799 patients (53% females) were included at baseline. Mean (SD) age at diagnosis was 7.70 (3.10) and mean (SD) HbA1c was 11.3% (2.3) . HbA1c was significantly different between females and males at baseline (11.6% vs. 10.9%; p<0.001) . In the follow-up period, 580 patients were included. Most patients achieved sub-optimal or high-risk compared to optimal glycemic control at follow-up (n=503, mean HbA1c 9.8% vs. n=77, mean HbA1c 6.9%; p<0.001) . Patients on CSII therapy were more likely to have better glycemic outcomes than patients on MDI therapy (OR = 4.86, 95% CI [1.66-14.2], p=0.004) . Height z-score was associated with poor glycemic control (OR = 1.24, 95% CI [1.017-1.515], p=0.034) . Most patients did not meet the glycemic control target defined by ISPAD, signaling a significant challenge faced by children with T1D in Kuwait. However, this study highlights the importance of making CSII therapy accessible. Individualized glycemic control goals may be needed to enhance diabetes management and care early at diagnosis.

Disclosure

T.Alqaisi: None. A.R.Alsaber: None. H.Alkandari: None. D.Al-abdulrazzaq: None.