bluuebunny/crossref_metadata_2025 huggingface dataset:
Shi-pi-xiao-ji formula suppresses hepatocellular carcinoma by reducing cellular stiffness through upregulation of acetyl-coA acetyltransferase 1
Authors: Jian Hui-Ying , Liang Zi-Cheng , Wen Huan , Zhang Zhen , Zeng Pu-Hua
Published: June 2024

BACKGROUND

Previous studies have shown that the Shi-pi-xiao-ji (SPXJ) herbal decoction formula is effective in suppressing hepatocellular carcinoma (HCC), but the underlying mechanisms are not known. Therefore, this study investigated whether the antitumor effects of the SPXJ formula in treating HCC were mediated by acetyl-coA acetyltransferase 1 (ACAT1)-regulated cellular stiffness. Through a series of experiments, we concluded that SPXJ inhibits the progression of HCC by upregulating the expression level of ACAT1, lowering the level of cholesterol in the cell membrane, and altering the cellular stiffness, which provides a new idea for the research of traditional Chinese medicine against HCC.

AIM

To investigate the anti-tumor effects of the SPXJ formula on the malignant progression of HCC.

METHODS

HCC cells were cultured in vitro with SPXJ-containing serum prepared by injecting SPXJ formula into wild-type mice. The apoptotic rate and proliferative, invasive, and migratory abilities of control and SPXJ-treated HCC cells were compared. Atomic force microscopy was used to determine the cell surface morphology and the Young’s modulus values of the control and SPXJ-treated HCC cells. Plasma membrane cholesterol levels in HCC cells were detected using the Amplex Red cholesterol detection kit. ACAT1 protein levels were estimated using western blotting.

RESULTS

Compared with the vehicle group, SPXJ serum considerably reduced proliferation of HCC cells, increased stiffness and apoptosis of HCC cells, inhibited migration and invasion of HCC cells, decreased plasma membrane cholesterol levels, and upregulated ACAT1 protein levels. However, treatment of HCC cells with the water-soluble cholesterol promoted proliferation, migration, and invasion of HCC cells as well as decreased cell stiffness and plasma membrane cholesterol levels, but did not alter the apoptotic rate and ACAT1 protein expression levels compared with the vehicle control.

CONCLUSION

SPXJ formula inhibited proliferation, invasion, and migration of HCC cells by decreasing plasma membrane cholesterol levels and altering cellular stiffness through upregulation of ACAT1 protein expression.
Testing the Bhaduri–Marglin model for the demand regime of Greece
Authors: Marsellou Emilia G.
Published: June 2024

This paper investigates the demand regime of the Greek economy for the period 1960–2017, using a Bhaduri/Marglin (1990) type macroeconomic demand-led model and applying the empirical methodology developed in Stockhammer et al. (2009). The analysis finds that Greece is another European economy with a wage-led demand regime, both domestically and as an open economy. Moreover, the analysis shows that the results are robust across different sample sizes, for the period 1960–2017, and the two sub-periods 1960–1989 and 1990–2017.
Bank credit, expected inflation rate, and financial dynamics
Authors: Watanabe Toshio
Published: June 2024

We investigate the effects of debt–capital ratio and expected inflation rate on the stability of the economy using a Minsky model and reconsidering Fisher’s debt-deflation theory. We have developed static and dynamic models that formalize an inflation-targeting policy. The static model reveals that an increase in the debt–capital ratio may negatively impact the profit rate and that the Fisher proposition is invalid. Our dynamic model indicates that the economy can become endogenously unstable. When the debt–capital ratio is high and the sensitivity of nominal wage rate to the profit rate is higher than that of bank lending, it may lead to debt-deflation. Finally, we demonstrate that the central bank alone can make only a limited contribution to economic stability.
The Effect of Learning Method and Self-Confidence on Student Learning Outcomes
Authors: Awaludin Asep , Ruhiat Yayat , Anriani Nurul , Suryadi Suryadi
Published: June 2024

Objective: This study examines the disparities in enhancing student learning outcomes based on learning methods and varying levels of student self-confidence, categorized as high, medium, and low. Method: This study employs quantitative methodologies utilizing quasi-experimental methods. The study uses a non-equivalent control group technique and follows a 2 x 3 two-way ANOVA factorial design. The study sample comprised 1000 students enrolled at the health Polytechnic Banten, an educational institution in Indonesia. The enormity of this scale requires the study to be divided into many portions due to the significant temporal and financial resources needed. Therefore, a sample size of 10.00% of the population was chosen. In addition, the researchers utilized a systematic random sampling method to determine the number of students involved in the study. Results:  The research findings can be classified into three main areas. Firstly, there were significant differences in student learning outcomes between those taught using STEM learning methods and those who received bedside teaching. Secondly, variations in student self-confidence levels (high, medium, and low) also resulted in differences in learning outcomes. Lastly, an interaction was observed between the learning methods and the levels of student self-confidence, which influenced the overall learning outcomes as measured by the average pre-test and post-test scores and questionnaires. Novelty: The novelty of this research was variations from previous research in terms of emphasis, subject, results, and combination of research variables. Previous research only concentrated on STEM methods and self-confidence to improve student learning outcomes. Previous research only examined one research variable: STEM, bedside teaching method, and self-confidence.
PHARMACOLOGICAL APPROACHES TO THE TREATMENT OF NONSPECIFIC BACK PAIN. REVIEW OF CLINICAL RECOMMENDATIONS
Authors: Ших Е.В. , Махова А.А. , Парфенов В.А.
Published: June 2024

Острая скелетно-мышечная боль (ОСМБ) в спине – одна из наиболее частых причин обращения за медицинской помощью. Ведение пациентов с ОСМБ – актуальная проблема современной медицины, так как ОСМБ служит причиной временной нетрудоспособности населения. Пациент с ОСМБ в спине должен быть информирован о доброкачественном характере заболевания, благоприятном прогнозе, целесообразности сохранять физическую активность и избегать постельного режима. Наибольшее применение в  лечении болевого синдрома в  спине получили нестероидные противовоспалительные препараты (НПВП). Также в комплексной терапии широко используют витамины, обладающие нейротропной активностью и  антиноцицептивным действием (В1, В6, В12). Исторически сложившаяся клиническая практика совместного назначения витаминов группы В и НПВП набирает все большую доказательную базу. На фоне комплексного применения НПВП и  препаратов, содержащих бенфотиамин, пиридоксин и  цианокобаламин, у  пациентов с  ОСМБ значительно снижается интенсивность боли и  уменьшается количество потребляемых анальгетиков, что  подтверждено клиническими исследованиями и  метаанализами. Использование двухступенчатой терапии вита‑ минными препаратами с переходом от инъекционных к таблетированным формам лечебных доз синергично действующих витаминов группы В способствует повышению эффективности фармакотерапии болевого синдрома, сокращению времени нетрудоспособности, удлинению безрецидивного периода и улучшению качества жизни пациента.

Acute musculoskeletal pain (AMSP) in the back is one of the most common reasons for seeking medical help. Management of patients with AMSP is an urgent problem of modern medicine, since AMSP causes temporary disability of the population. A  patient with AMSP in the back should be informed about the benign nature of the disease, a favorable prognosis, the advisability of maintaining physical activity and avoiding bed rest. Non-steroidal anti-inflammatory drugs (NSAIDs) are most widely used in the treatment of back pain. Vitamins with neurotropic activity and antinociceptive effects (B1, B6, B12) are also widely used in complex therapy. The historical clinical practice of co-prescribing B vitamins and NSAIDs is gaining increasing evidence base. With the combined use of NSAIDs and drugs containing benfotiamine, pyridoxine and cyanocobalamin, patients with AMSP significantly reduce pain intensity and reduce the amount of analgesics consumed, which is confirmed by clinical studies and meta-analyses. The use of two-stage therapy with vitamin preparations with a transition from injection to tablet forms of therapeutic doses of synergistically acting B vitamins helps to increase the effectiveness of pharmacotherapy for pain syndrome, reduce the time of disability, lengthen the relapse-free period and improve the patient’s quality of life.
Text mining of monologues by Waldorf and Montessori teacher trainers
Authors: Turós Mátyás
Published: June 2024

Using text-mining methods and a genealogical discourse analysis, our comparative study aims to explore the views of Waldorf and Montessori teacher trainers. The data was collected through structured interviews. The sample consists of eight respondents involved in Montessori teacher training and eight respondents involved in Waldorf teacher training (Ntotal = 16). Our research objective is to identify the lexical and narratological features, similarities and differences in the monologues of expert teachers with the aim of their interpretive evaluation. The literature review provides a brief summary of recent research on didactics and effectiveness, as well as some critiques of Montessori and Waldorf pedagogy
Microemulsion technology: Nanoparticle-based emulsion as a sustainable natural product formulation
Authors: Sembiring Mikael Ham , Arsyadi  , Riadi Taufik
Published: June 2024

Natural products refer to chemicals or compounds from living creatures occurring naturally in the environment. Natural commodities, such as spices, herbs, and medical remedies, are often used as additions. Natural products have many advantages, such as their environmentally sustainable nature, compatibility with the skin, affordability, and widespread availability. Nevertheless, developing natural products has several challenges, such as limited options for ingredients, functional limitations of natural substances, considerations about stability and preservation, consumer perceptions and expectations, and the variability in the composition of natural products. Microemulsions are prevalent emulsions that incorporate nanoparticles. A microemulsion is a homogeneous, transparent liquid consisting of oil, water, and a surfactant, often combined with a cosurfactant. The use of microemulsions has been extensively observed in many chemical and pharmacological applications owing to their unique attributes, such as a significant interfacial area, little interfacial tension, and the ability to solubilise and deliver hydrophobic substances. Therefore, the present review paper aims to comprehensively analyse microemulsion technology and its applications as an environmentally friendly formulation for natural products. Here, we propose strategies and research on microemulsions to overcome problems in natural product formulations.
The effects of saluang belum (Luvunga sarmentosa) root infusion on sperm motility, viability, and testicle histology in mice (Mus musculus)
Authors: Permatasari Silvani , Christin Sherina Natalia , Rahmatina Hairunnida , Adnyana I Gde Hary Eka
Published: June 2024

Background: Men's infertility is frequently caused by a decrease in sperm quality. Herbal medicine, which is relatively cheap and easy to obtain, can be used to treat this condition. People in Central Borneo frequently consume boiled Saluang Belum root (Luvunga sarmentosa). L. sarmentosa root has the potential to improve sperm quality.     
Objective: To investigate the effects of Saluang Belum root infusion on sperm cell survival and testicle histology in mice (Mus musculus).
Method: L. sarmentosa root was extracted using an infusion method, analysed and administered to mice at doses of 200 mg/kgBW, 400 mg/kgBW, and 600 mg/kgBW. Aquadest was used as a negative control for 15 days. On the 16th day, sperm motility and viability were assessed. The right testicles were removed and examined under a microscope at 100x and 400x magnification for five fields of view to examine mice testicle histology.    
Result: Infusion of L. sarmentosa contained triterpenoids, flavonoids, steroids, alkaloids, saponins, and phenols. Statistical tests of infused L. sarmentosa root on the motility, viability sperm and spermatogenic potentials of mice indicated that the doses of 200mg/kgBW, 400mg/kgBW, and 600mg/kgBW are significantly increased than control.    
Conclusion: L. sarmentosa root infusion increased sperm motility and viability, and the spermatogenic cells, as well as Leydig cells in mice.
Antidiabetic and antioxidant activity of Clitoria ternatea flower extracts and fractions on blood glucose and MDA in rats induced by alloxan
Authors: Utami Widyaningrum , Laksono Yunanto Dwi , Setiawibowo Syakira Nilam Farhana , Sunarsih Endang Sri , Wulandari Fitri , Rohana Evieta
Published: June 2024

Background: Clitoria ternatea, rich in anthocyanins with antioxidant properties, can help prevent oxidative stress and reduce complications associated with diabetes mellitus (DM).
Objective:  To investigate the antidiabetic and antioxidant properties of the ethanol extract and ethyl acetate fraction of Clitoria ternatea in rats induced by Alloxan.
Method: Ethanol extract from Clitoria ternatea was fractionated with ethyl acetate and then screened for phytochemicals using TLC. Antidiabetic and antioxidant activities were evaluated on alloxan-induced hyperglycemic rats at 150 mg/kgBW and 300 mg/kgBW, respectively.
Result: The Clitoria ternatea flower's ethanol extract and ethyl acetate fraction had a flavonoid content of 68.003±0.366 mg QE/g and 78.767±0.262 mg QE/g, respectively. The ethyl acetate fraction, administered at 300 mg/kg BW, showed a 45.5986 mg/dl reduction in blood glucose levels, not significantly different from the positive control (acarbose (p = 0.14). The ethyl acetate fraction showed a significant reduction of 76.5% in MDA levels, similar to quercetin as a positive control (p = 0.275).
Conclusion: Clitoria ternatea showed antidiabetic and antioxidant properties in alloxan-induced rats.
A network pharmacology-based approach to explore the potentials of Saluang belum (Luvunga sarmentosa) in the male human reproductive system
Authors: Permatasari Silvani , Toepak Erwin Prasetya , Irmawan Muhammad
Published: June 2024

Background: Saluang belum's root (Luvunga sarmentosa) is one of the local plants in Central Kalimantan and is used by the Dayaknese to increase sexual activity. In previous research, L. sarmentosa root extract compounds have been characterised, but the bioactivity of each on male fertility has not been studied.
Objective: To use bioinformatics to study the effects and mechanisms of molecular compounds of L. sarmentosa extract on the biological system of the male fertility complex.
Methods: Network pharmacology methods were used to determine target essentially functional proteins in biological system networks. The molecular mechanism of L. sarmentosa compound activity was analysed using molecular docking and dynamic simulation software such as Autodock 4 and MOE.
Result: The network pharmacology analysis showed that the Pregnane X receptor (PXR) protein contributed essentially to male reproductive biological functions. Based on the molecular docking simulations of PXR, 6-phenyl-3,4-dihydro-1H-1,4,5-benzotriazocin-2-one was the best. Pharmacological and toxicity parameters also showed that this compound had good characteristics. In addition, the molecular dynamics simulations showed that the best compounds could maintain complex interactions with PXR based on the resulting RMSD values.
Conclusion: The compound 6-phenyl-3,4-dihydro-1H-1,4,5-benzotriazocin-2-one had the most potential as a PXR inductor. This compound also had a better activity than the standard inductor.
Comparison of maceration and infundation towards antioxidant capacity of leaves aqueous extracts of balik angin (Alphitonia incana (Roxb.) Teijsm. & Binn. ex Kurz)
Authors: Ramadhan Hafiz , Susiani Eka Fitri , Forestryana Dyera , Raflianti Dinda , Azizah Haura Nur , Iedliany Faradilla
Published: June 2024

Background: Excessive exposure to free radicals can trigger various degenerative diseases. Therefore, external antioxidants are needed from nature. One plant with the potential as a natural antioxidant is Balik Angin (Alphitonia incana (Roxb.) Teijsm. & Binn. Ex Kurz).
Objective: This study aimed to determine the differences in the content of secondary metabolites and the antioxidant capacity of the aqueous extract of balik angin leaves from two different extractions.
Method: The extraction methods were maceration and infundation, followed by phytochemical screening to identify secondary metabolites. The antioxidant activity assay was carried out by UV-Vis spectrophotometry by measuring the absorbance of the sample reaction with CUPRAC and FRAP reagents.
Result: The phytochemical screening results of balik angin leaves infusion contained phenols, flavonoids, saponins, triterpenoids, and tannins, while the macerated extract obtained triterpenoids and tannins negatively. The quantitative assay showed the balik angin leaves infusion resulted in a powerful antioxidant category with EC50 values of 17.762 µg/mL and highly antioxidant content, which was 726 mg AAE/g extract compared to macerated aqueous extract antioxidant capacity with EC50 values of 44.719 µg/mL and 635 mg AAE/g extract antioxidant content.
Conclusion: The infused aqueous extract of balik angin leaves has the potential to be a powerful antioxidant compared to the maceration product.
Molecular docking and toxicity analysis of ribosome-inactivating protein and natural chemical compounds as promising antiretroviral candidates against HIV-1
Authors: Sembiring Mikael Ham , Pradana F. Josse Pasca , Putra Oktavian Arya , Tuba Syahrul
Published: June 2024

Background: HIV (human immunodeficiency virus) uses HIV-1 reverse transcriptase as the receptor to convert RNA into viral DNA. In addition, the CD4 receptor is also used by the virus to enter CD4+ T cells and subsequently replicate.
Objective: To screen several proteins in Indonesian plants for the potential to bind to the CD4 receptor.
Method: Molecular docking was carried out on Cluspro 2.0 specifically for protein to protein and MOE for protein to ligand.
Results: The protein ligands were Cinnamomin III, Agglutinin, PAP, PAP-S, Momordin I, MAP30, Beta-luffin, Luffaculin I, Cucurmosin, DAP, Dianthin-30, Bouganin, Maize, Ricin, Abrin, Balsamin, and the bond energy values  (Joules/kg.mol) were -602.8, -973.5, -511.3, -439.1, -532.2, -661.9, -487.0, -472.8, -530.9, -413.6, 444.1, -504.5, -617.2, -855.6, -883.9, -558.6, respectively. The best binding energy with CD4 was selected to identify the compound's molecule. These compounds were abrusin, abrusogenin, eicosadienoic acid, heneicosane, precatorine, and trigonelline, and the bond energy values (Joules/kg.mol) were -19.2158, -16.7057, -15.5155, -13.9632, -15.6119, and -9.2620, respectively. The toxicity test of abrusin was carried out against 18 targets, and two targets showed toxic activities.
Conclusion: The content of RIP and natural chemical compounds in Abrus precatorius seeds make them the best candidate for antiretroviral therapy against HIV-1.
Distribution of genetic polymorphism of the PTP1B gene in diabetes mellitus patients taking insulin therapy in Indonesia: A narrative review
Authors: Fakhruzain Nafrizal , Tuba Syahrul
Published: June 2024

Background: Diabetes mellitus is a metabolic disease directly related to the onset of hyperglycemia, which occurs due to abnormalities in insulin secretion, insulin action, or both. Protein Tyrosine Phosphatase 1B (PTP1B) from insulin receptor signal transduction has a role in the pathogenesis of diabetes mellitus.
Objective: To briefly present the distribution of genetic polymorphism of the PTP1B gene in diabetes mellitus patients taking insulin therapy.
Method: A narrative review was conducted by collecting scientific journals in English from several leading platforms, such as PubMed, CrossRef, and Google Scholar, published from 2012 to 2023.
Result: PTP1B can inhibit glucose transporter type 4 (GLUT4) activation in glucose uptake by cells, increasing glucose levels. The use of exogenous insulin becomes ineffective, and insulin resistance occurs. This study has limitations and needs additional prospective investigations to corroborate the findings.
Conclusion: In some studies, PTP1B gene polymorphism in diabetes mellitus patients strongly correlates with insulin therapy. PTP1B gene polymorphism can cause insulin resistance because PTP1B and GLUT4 have the opposite effect.
comicidade musical de Chiquinha Gonzaga e a ressonância com os palhaços cantores no Brasil
Authors: Tibúrcio Caísa
Published: June 2024

O presente estudo teve por objetivo tratar das possíveis relações entre a obra musical de Chiquinha Gonzaga e a musicalidade explorada por palhaços musicais. É sabido que no fim do século XIX e início do século XX, o Brasil vivia um contexto de multiplicidades evidentes e processos políticos emancipatórios o abolicionismo e a Proclamação da República, por exemplo. Apesar das expectativas hegemônicas do quadro político brasileiro, a contracena dos movimentos marginais evidenciava os artistas populares, os palhaços, e os poetas de calçada. Nesse contexto, Chiquinha Gonzaga desponta como uma das vozes mais representativas da arte nacional. Como viés metodológico, procedeu-se o cruzamento de dados documentais existentes na biografia de Chiquinha Gonzaga e em livros de pesquisadores das temáticas palhaçaria e circo brasileiro. Concluiu-se que a contribuição de Chiquinha Gonzaga, como mulher maxixeira, refletiu em uma comicidade musical fixada e amplamente divulgada pelos palhaços cantores nos circos, no circo- teatro e na crescente indústria fonográfica brasileira.
Folclorul Matematic. Probleme Populare
Authors: TATARU Ionel
Published: June 2024

In the people, from ancient ancestors, a certain species of turmoil of the mind of man interested in training the skill and plasticity of his thinking to solve problematic situations quite often attested in everyday life is practiced. Among them is quite often attested the popular problem related to the most varied and diverse everyday situations of man. Mathematical folklore is an immense wealth of the people of which folk problems constitute a small part. They are pearls, each of them constituting a part of the most precious quality of a people – its wisdom, which educates itself the finest side – impeccable logical thinking.
Pengaruh Celebrity Endorser, Electronic Word of Mouth, Content Marketing Tiktok terhadap Keputusan Pembelian Produk Scarlett Whitening
Authors: Maudy Calista Rizqy , Setyawati Christina Yanita
Published: June 2024

Scarlett Whitening is a company engaged in the beauty sector and has been officially established since 2017. The Scarlett Whitening company uses social media as a tool to market products and find out customer needs and wants. The aim of this research is to understand the influence of celebrity endorser, electronic word of mouth, content marketing TikTok towards purchase decision of Scarlett Whitening product. This research uses quantitative descriptive alongside with purposive sampling. This research the sample used was 97 people with an age range of 16-60 years. The researchers use SPSS version 26 to process the data, with multiple linear regression as the main method. Based on the result of the study, it is indicated that the electronic word of mouth and content marketing does not significantly influence Purchase decision, while the celebrity endorser has a significant effect on purchase decision of Scarlett Whitening product.Celebrity endorsers, electronic word of mouth and content marketing together can measure the dependent variable, namely purchasing decisions.
Tinjauan Literatur: Hubungan Stunting terhadap Keparahan Karies Gigi Sulung dan Kebersihan Rongga Mulut pada Anak Usia Sekolah Dasar
Authors: Fasya Safira
Published: June 2024

The purpose of this study was to analyze the effect of stunting on the severity of caries of deciduous teeth and the level of oral hygiene in children. Method: the systematic literature review taken from national journals and international journals is used. Results: From 10 selected journals there was a significant correlation between stunting children and the severity of dental caries in children. The effects of stunting in addition to impaired cognitive function also affect the severity of dental caries and oral hygiene. Children with malnutrition have higher dental caries than children with good nutrition. This is due to changes in salivary characteristics and salivary secretions to decrease causing cavities in the oral cavity. Saliva as a cleaning and anti-bacterial agent in the oral cavity. As a result of dental caries that causes pain, interferes with masticatory function and affects nutritional status. Conclusion: From various types of studies it is proven that children with stunting have various impacts on the growth and health condition of their teeth and mouth. It can be seen from the high incidence of caries in children and it is also found that there are changes in conditions in the oral cavity that cause a decrease in the rate of salivary flow.
RADIATION IN THE MICROWAVE RANGE AT PULSE ACCELERATORS WITH VIRTUAL CATHODE GENERATOR
Authors: Katrechko V.V. , Vinnikov D.V. , Manuilenko O.V. , Ozerov O.M. , Onishchenko I.N. , Tkachev V.I. , Yuferov V.B. , Marchenko S.V.
Published: June 2024

The energy and design parameters of some vircator systems are considered. Calculated cutoff frequencies for the main E and H modes of the DIN-2K accelerator waveguides with electron beam parameters: ~ 15 kA and ~ 185 kV. The characteristic frequencies of oscillations of the virtual cathode depending on the distance of the anode-cathode
gap were calculated. Experimentally obtained amplitude-frequency spectra (up to 6 GHz) in the far zone of electromagnetic radiation (Fraunhofer zone) for a horn antenna.
ASSESSMENT OF RADIOACTIVE AND CHEMICAL IMPURITIES IN PERTECHNETATE PRODUCED BY PHOTONUCLEAR TECHNOLOGY
Authors: Dikiy N.P. , Krasnoselskiy N.V. , Lyashko Yu.V. , Medvedeva O.P. , Medvedev D.V.
Published: June 2024

The results of the release of 99Mo of molybdenum foil irradiated at LAE with E = 22 MeV and I = 700 μA are presented. The technology of electrolytic deposition 99mTc with its subsequent conversion into a radiopharmaceutical – pertechnetate is considered. The content of chemical and radionuclide impurities in pertechnetate was monitored, as well as testing of the radiopharmaceutical with various carriers for the diagnosis of animal organs.
Challenges of Arabic – English Translation
Authors: Zafar Tojiyeva Zamira , Komilovich Ermatov Usmonjon
Published: June 2024

Arabic language is a rich language with a vast vocabulary, including terms that may not have direct equivalents in other languages. Translation is a field of contrastive linguistics since it is associated with at least two languages and their cultures. It is the process of conveying the text by transferring from one system of language to the other and often need to employ creative techniques to convey the richness of the original text in the translated version.  In this article the focus will be on the problems of translating from Arabic language or into Arabic and will give several solutions.
Cognitive Semantic Features of Phraseological Units Denoting Human Intellectual Abilities in English and Uzbek Language
Authors: Norboboyevna Gulchexra Tursunova
Published: June 2024

The exploration of phraseological units through a cognitive semantic lens has garnered significant attention, revealing insights into how language reflects underlying cognitive structures. This study builds upon existing research by examining English and Uzbek phraseological units related to human intellectual abilities. Drawing on cognitive linguistic theories, including conceptual metaphor and image schemas, the research aims to uncover the cognitive semantic features embedded in these units. A comprehensive analysis reveals that both English and Uzbek phraseological units utilize metaphorical extensions, metonymic representations, image schemas, and conceptual metaphors to convey intellectual concepts. However, cultural and linguistic factors shape the expression of cognitive semantic features. English may employ diverse metaphors spanning different sensory experiences, while Uzbek might focus more on visual and physical metaphors. Cultural nuances influence expressions like "swallowed a book" in English and "kitob yutgan" (swallowed a book) in Uzbek, reflecting unique cultural experiences and values regarding knowledge acquisition. The study underscores the importance of considering cultural and linguistic factors in understanding cognitive semantics across languages. By examining both universal cognitive schemas and culturally specific expressions, the research contributes to a deeper understanding of how human intellectual abilities are conceptualized and articulated through language.
Article RETRACTED due to manipulation by the authors The Hybrid Learning System With Project Based Learning: Can It Increase Creative Thinking Skill and Learning Motivation in Physical Education Learning?
Authors: Festiawan Rifqi , Sumanto Eko , Febriani Ayu Rizky , Permadi Asep Angga , Arifin Z. , Utomo Andri Wahyu , Nugroho Wildan Alfia , Pratama Kukuh Wahyudin
Published: June 2024

This research aims to determine the effect of hybrid learning using the project based learning method on creative thinking abilities and learning motivation. The research method is the true experimental research technique, utilizing The Randomized Pretest-Posttest Control Group Design. The population for this study included all students in Senior High School 1 Purwokerto, totaling 1015 students across 36 classes. Simple random sampling was employed to select a total sample of 112 students (n = 112, age = 17.1 ± 1.2 years). This research uses two instruments to obtain data, including 1) The Torrance Tests of Creative Thinking (TTCT) and 2) The Motivated Strategies for Learning Questionnaire (MSLQ). The data analysis used was the data normality test, data homogeneity test, paired t-test and independent t-test. The data used is normally distributed (sig=0.434) and homogeneous (sig=0.533), The research results show that the effect of Hybrid Learning with the Project Based Learning method on creative thinking skills and learning motivation (sig=0.000), control group (sig=0.002), and there is a significant difference in effect between the treatment group and the control group (sig=0.000). It can be concluded that 1) PjBL model has a favorable impact on students' critical thinking skills in physical education, 2) PjBL model positively influences learning motivation in physical education, and 3) PjBL model yields a more positive outcome compared to the direct teaching model in enhancing students' creative thinking skills in the context of physical education.
Keyword: Critical Thinking Skills, Hybrid Learning, Learning Motivation, Project Based learning
Juego Educativo "Pusaran Ular Tangga" En la mejora de las habilidades motrices fundamentales (FMS) de los alumnos de tercer curso de primaria (Educational Game "Pusaran Ular Tangga" To Improve Fundamental Motor Skill (FMS) of Grade 3 Elementary School Students)
Authors: Hadyansah Diky , Dimyati Dimyati , Ardiyanto Hermawan Hedi , Maulana Fadillah Hikmah , Rizkia Mulyana Fegie
Published: June 2024

La deficiencia de las Habilidades Motrices Fundamentales (HMB) entre los niños es una preocupación importante a la hora de promover la actividad física. La combinación de ejercicios estructurados y juegos estructurados es una medida eficaz para mejorar las Habilidades Motrices Fundamentales de los escolares. El objetivo de este estudio es determinar el efecto del juego educativo "Pusaran Ular Tangga" en las DPM de los alumnos de 3º de primaria. Este método de investigación es un método experimental con un diseño preprueba-postprueba de un solo grupo. Esta investigación se llevó a cabo en alumnos de 3er grado de primaria de la Regencia de Bandung Oeste con una muestra de 30 personas utilizando la técnica de muestreo total. Se midieron las habilidades motrices básicas mediante pruebas prácticas con el instrumento Test Of Groos Motor Skill - (TGMD 2) para edades comprendidas entre los 3 y los 10 años. Sobre la base de la prueba de Wilcoxon, se sabe que el valor de significación de 0,000 es menor que <0,05, se puede concluir que el juego educativo "Pusaran Ular Tangga" tiene un efecto en el aumento de la Habilidad Motora Fundamental de los alumnos de 3er grado de primaria. La diferencia en la mejora de la habilidad motriz fundamental entre antes y después del tratamiento es del 36%.
Palabras clave: Juegos educativos, Actividad física, Habilidades motrices fundamentales, Niños en edad escolar.
Abstract. The poor Fundamental Motor Skills (FMS) among children is an important concern in promoting physical activity. The combination of structured exercises and structured games is an effective measure to improve the Basic Motor Skills of school children. This study aims to determine the effect of educational game "Pusaran Ular Tangga" on FMS of 3rd grade students. This research method is an experimental method with Single-Group Pretest-Posttest Design. This research was conducted on grade 3 elementary school students in West Bandung Regency with a sample of 30 people using the total sampling technique. Measurement of Basic Motor Skills using practical tests measured by the Test Of Groos Motor Skill - (TGMD 2) instrument for ages 3-10 years. Based on the Wilcoxon test, it is known that the significance value of 0.000 is smaller than <0.05, it can be concluded that the educational game “Pusaran Ular Tangga” has an effect on increasing the Fundamental Motor Skill of grade 3 elementary school students. The difference in the improvement of Fundamental Motor Skill between before and after treatment is 36%.
Keywords: Educational Games, Physical Activity, Fundamental Motor Skills, School Age Children
How can bullying affect body image? A systematic review to understand the relationship between bul-lying, body image and eating disorders
Authors: Martínez-López María , Gil-Madrona Pedro , Montoya-Fernández Carlos , Gómez-Barreto Isabel María
Published: June 2024

Nowadays bullying has become one of the biggest challenges faced by teachers all around the world due to the consequences it has on the victims in the long and short term. The most common consequences expressed by bullying victims are anxiety, depression, socialization problems, lower self-esteem, and a negative perception of their body image. The negative perfection of body image has a very strong relationship with the development of eating disorders. Due to this fact, it is crucial to study the relationship that bullying and eating disorders might have. By using PRISMA model (Page et al., 2021) a systematic review to prove this relationship has been developed. After searching and analyzing different articles, the included sample and the instruments used, it was possible to conclude that being a victim of bullying is related with developing an eating disorder. For this reason, it is crucial to create prevention programs at schools that help teachers, parents and the different professionals to face both problems as it is essential to keep students safe inside and outside the classroom.
Keywords: Bullying; eating disorders; body image; systematic review; physical education; prevention.
Availability and Usage of Electrophysical Agents by Portuguese Physiotherapists: an online Survey
Authors: Paquete Manuel , Harry Leite Pedro , Bernardo Diana , Moreira Luís
Published: June 2024

Objective: The aim of this study is to describe the availability and usage of Electrophysical Agents (EPAs) by Portuguese Physiotherapists (PTs), and identify factors affecting its’ usage, such as PTs expertise, setting and autonomy.
Methods: A cross-sectional study was carried out between July and September 2018. Physiotherapists currently practicing in Portugal were invited to complete an online survey. The online survey included questions regarding the participants' practice, such as years of experience, rehabilitation autonomy, number of clients per hour, context and availability and use of EPAs. Results: From a total of 544 PTs that responded to the survey, 424 (78 %) used EPAs on their daily practice. The most common available EPAs are Transcutaneous Eletrical Nerve Stimulation (99%) and Ultasound (91%). When available, more than 80% of the participants reported using the different EPAs at least one time. All participants reported using the different EPAs more than 80%, when they are available. PTs expertise does not influence the selection of EPAs however, the autonomy and setting influenced the selection of almost of the different EPAs. Discussion: EPAs are commonly available and generally used by Portuguese PTs. PTs that works autonomously tend to use less EPAs. The EPAs selection seems to be dependent on the setting, number of clients per hour and autonomy.
Keywords: Electrophysical agents, Physiotherapy, usage, availability; TENS; US
Association of the MuRF-1/TRIM63 polymorphism with muscle injuries in professional soccer players
Authors: Silva Fagundes Leonardo Henrique , De Sousa Pinheiro Guilherme , Mendonça Pimenta Eduardo , Neves Amorim Carlos Eduardo , Pedra de Souza Renan , Teoldo da Costa Varley
Published: June 2024

Muscle injuries are one of the biggest medical problems in professional soccer. Evidence has suggested that genetic polymorphism is a mediating factor in physiological and structural alterations that can lead to muscle injury. The TRIM63 gene polymorphism may affect the MuRF-1 protein, which is vital in the regulation of muscle mass, and is differentially regulated by exercise mode, muscle contraction, and training status. However, central aspects of the relationship between genetic variations, the environment, and muscle injuries still need to be explained. This study aimed to investigate whether MuRF-1/TRIM63 (A/G, rs2275950) was associated with the occurrence of muscle injury in professional soccer players. Forty-six Brazilian soccer players were evaluated. Genomic DNA was extracted using blood samples and semi-structured interviews on muscle injuries were applied after two seasons (2021-2022). Fisher's exact test was used to verify if MuRF-1/TRIM63 was associated with muscle injuries. The MuRF-1/TRIM63 genotypes (c2 = 2.19; p = 0.292), the dominant model (c2 = 1.04; p = 0.299), and the recessive model (c2 = 1.94; p = 0.208) showed no association with muscle injuries in soccer players. Preliminary evidence suggests that this genetic polymorphism may not be a reliable biomarker of muscle injuries in Brazilian professional soccer players.
Keywords: Football; Genetic, Muscle injury, Performance, Single Nucleotide Polymorphism (SNP), Sport genomic.
Genealogy on Policies and Strategies of Physical Education for Elementary Schools in Indonesia
Authors: Sumarjono Sumarjono , Nopembri Soni , Yuliarto Hari
Published: June 2024

This paper delves into an examination of policies and strategies for physical education in elementary schools, with a specific focus on assessing their effectiveness and sustainability to enhance the overall quality of physical education. Employing a qualitative approach that involves a comprehensive review of relevant literature, the study aims to scrutinize and evaluate the impact of these policies and strategies. The findings highlight crucial elements essential for effective physical education, such as the development of a well-rounded curriculum, accurate assessment methods, continuous teacher training, institutional and governmental support, integration of modern technology, fostering community partnerships, and active involvement of parents. The conclusions drawn from this research underscore the critical importance of implementing robust policies and strategies to address the existing challenges in elementary school physical education. Furthermore, the study emphasizes the potential for significant improvements in the effectiveness and sustainability of physical education through the adoption and implementation of these measures, ultimately paving the way for a more holistic and beneficial educational experience for students.
Key words: policy, physical education, elementary school, sports strategy.
How is the stakeholder perspective for undergraduate nursing focused on sports nursing? : qualitative study in curriculum development
Authors: Yusuf Ah , Aditya Ronal Surya , Rahmatika Qory Tiffani , Sunaryo Eri Yanuar Akhmad Budi , Masfi Achmad , Afiani Nurma , Widjayanti Yhenti , Ramadhan Muhammad Putra , Evi Nurul , AlMutairi Reem Iafi , Razeeni Daifallah M. Al , Alruwaili Abdullah Saleh
Published: June 2024

Background: In the realm of sports nursing, emergent and innovative educational models are built upon the foundation of stakeholder engagement. Despite the fact that numerous studies have examined the stakeholder perspective in nursing, a greater number of studies have examined stakeholder perspectives in curricula that emphasize athletic nursing. Therefore, the objective of this study is to examine the viewpoints and concerns of relevant parties regarding the creation of a baccalaureate nursing program with a specific emphasis on sports nursing. Methods: A phenomenological study was conducted. This method combines descriptive features (Husserlian) and interpretive phenomenology (Gadamerian). Nineteen stakeholders participated in this study. The interview was ended when data saturation was reached, especially theme redundancy. Results: Three major themes were identified: (1) “Bridges” Which Combines Education And Work Context; (2) Stakeholder Engagement, Controversial Issues (3) Stakeholder Engagement, Structuring A Methodology. This finding shows that. Conclusion: The obligation of nursing education to align with current and future practice needs is emphasized, suggesting strategies such as curriculum mapping to bridge theoretical knowledge with clinical practice. Stakeholder engagement is crucial for successful education and professional development.
Keyword: Humans, Models, Educational, Stakeholder Participation, Curriculum, Education, Nursing, Health and Well-being, Quality Education
The Impact of Parental Support on Performance Achievement through Achievement Motivation in Elite Athletes in South Kalimantan, Indonesia: A Cross-Sectional Study with Structural Equation Modeling Analysis
Authors: Imtihansyah Rudi , Tomoliyus Tomoliyus , Sukamti Endang Rini , Fauzi Fauzi , Prabowo Trisnar Adi , Prayoga Hegen Dadang , Fitrianto Ari Tri , Amalia Bonita
Published: June 2024

This study aims to analyze the effect of parental support (PS) on performance achievement (PA) through achievement motivation (AM) in South Kalimantan province. Cross-sectional method was used in order to avoid errors and biases. The analysis used structural equation modeling (SEM) with the help of smart PLS. The sample was 120 athletes (67 men and 53 women); the characteristics (mean±SD) were as follows: aged 20.2±2.4, have 6.6±8.1 years of training experience, have 12.4±2.8 years of training, have 15.5±6.4 years of competition age, and have ten hours of training duration (five meetings a week). The types of sports included football, basketball, volleyball, athletics, swimming, boxing, tennis, pencak silat, gymnastics, and archery. The research instrument, in the form of a statement item presented as a questionnaire, was then distributed through Google Forms and has gone through the validation stage. The results showed that all items showed outer loading >0.7 and Cronbach’s alpha >0.9. The goodness of Fit (GoF) showed the value of Standardized Root Mean Square Residual (SRMR) was 0.061<0.08 or <0.10. Path analysis (P-Values) showed AM on PA was 0.000, PS on AM was 0.000, PS on PA was 0.002, and PS on PA through AM was 0.000. The results of this study are expected to add insight for a coach and athlete that it is important to involve parents in the context of achievement sports. The suggestion from the results of this study is to add more samples and develop relevant variables about the impact of parental support on athlete performance and achievement motivation.
Keywords: Parental Support, Achievement Motivation, Performance Achievement, Athlete
Features of institutional innovation management
Authors: Петросян Д.С. , Столярова А.Н. , Машин Д.В. , Боташева Л.С.
Published: June 2024

В статье проведена систематизация инноваций, уточнено понятие «институциональная инновация», определены основные понятия теории управления институциональными инновациями.

The article systematizes innovations, clarifies the concept of “institutional innovation”, defines the basic concepts of the theory of institutional innovation management.
Transformation processes in the Russian fuel and energy complex within the framework of the concept of sustainable development
Authors: Басиров М.Б.
Published: June 2024

В статье анализируются трансформационные процессы в российском топливно-энергетическом комплексе в рамках концепции устойчивого развития. Отмечается, что топливно-энергетический комплекс является пионером в России в вопросах внедрения принципов устойчивого развития и движения к углеродной нейтральности, так как ориентирован на экспорт своей продукции, в том числе в те страны, где устойчивое развитие и зеленая повестка играют важную роль. Для успешной конкуренции на мировом рынке энергоресурсов российские нефтегазовые и энергетические компании с середины 2000-х годов активно публикуют в открытом доступе экологические отчеты и отчеты об устойчивом развитии.

The article analyzes transformation processes in the Russian fuel and energy complex within the framework of the concept of sustainable development. It is noted that the fuel and energy complex is a pioneer in Russia in introducing the principles of sustainable development and the movement towards carbon neutrality, as it is focused on exporting its products, including to those countries where sustainable development and the green agenda play an important role. To successfully compete in the global energy market, Russian oil and gas and energy companies have been actively publishing environmental and sustainability reports in the public domain since the mid-2000s.
THE LAW-ENFORCEMENT ACTIVITY OF THE COURT IN AN ADVERSARIAL ADMINISTRATIVE PROCESS
Authors: Иванченко Е.А. , Воротилина Т.В. , Шульженко И.С.
Published: June 2024

Исследуя отдельные вопросы злоупотребления активной состязательностью, авторы статьи рассматривают институт состязательности в различных аспектах: как конституционный принцип, как вид процессуальной деятельности, как способ исследования доказательств и как форму доказывания в суде. Состязательность, таким образом, определяется в качестве унифицированного порядка и основополагающей организации, которыми может злоупотребить участвующая в процессе сторона в любом виде судопроизводства.

Examining individual issues of abuse of active competition, the authors consider the institution of competition in various aspects: as a constitutional principle, as a type of procedural activity, as a way of examining evidence and as a form of proof in court. Adversarial proceedings are thus defined as a unified order and fundamental organization that can be abused by a party involved in the process in any type of legal proceedings.