bluuebunny/crossref_metadata_2025 huggingface dataset:
O judeu na literatura para crianças e jovens. Uma leitura com História.
Authors: D'Alte Pedro
Published: July 2019

A diegese d’O caderno do avô Heinrich dá a conhecer uma personagem que migra por força da perseguição cultural e religiosa. Heinrich refugia-se, nos últimos anos da sua vida, em Portugal. A referência narrativa desperta, desde logo, a curiosidade pela possível relação entre a fé judaica e o espaço geográfico português. Por outro lado, sendo tão breve, a mesma oculta todo o tecido histórico que se entretece entre ‘Portugal’ e o ‘Judaísmo’2. Porque merecedor de atenção académica, o trabalho que aqui se apresenta pretende ler os imagótipos judaicos presentes em narrativas para jovens - em articulação com a historiografia portuguesa -, com o intuito de relembrar e de tornar visível este rico património histórico.
OLHARES E VOZES SOBRE A LITERATURA CONTEMPORÂNEA DE ANGOLA: LEITURAS DE MAYOMBE E NOITES DE VIGÍLIA
Authors: Ferreira Derneval Andrade , Dos Santos Adelino Pereira
Published: July 2019

Este artigo tem por objetivo apresentar reflexões e discussões sobre as narrativas Mayombe, de Pepetela, e Noites de Vigília, de Boaventura Cardoso, problematizando-as no sentido de buscar e construir respostas agenciadoras da nova realidade sociocultural dos angolanos, pós-independência de Angola. Assim, questões a respeito dos discursos sobre os romances, os itinerários espaciais percorridos pelos autores, narradores e personagens, palavras, expressões, gestos, e outras formas discursivas, como instrumentos de linguagem que cadenciam a consciência social, foram considerados elementos relevantes para que novos olhares e dizeres fossem construídos e reconstruídos. Uma primeira versão deste texto foi apresentada como parte de um capítulo da tese de doutorado em Estudos Étnicos e Africanos, de um dos autores deste trabalho, defendida em 2016.
Revisionismo ilustrado em A bela e a adormecida, de Neil Gaiman e Chris Riddell
Authors: Gomes João Pedro Fernandes
Published: July 2019

A bela e a adormecida, dos britânicos Neil Gaiman e Chris Riddell, é um livro ilustrado publicado em 2014 que se destaca ao reformular elementos de dois contos de fadas canônicos, Branca de Neve e A Bela Adormecida, integrando-os em um só. Faz isso propondo uma perspectiva revisionista, ressignificando elementos cristalizados e proporcionando um novo e mais crítico ângulo de análise (MARTINS, 2006). Este artigo usa os preceitos de Perry Nodelman (1988) para mostrar como o efeito revisionista pretendido pela obra se relaciona com as escolhas do ilustrador em relação ao texto-fonte. Percebemos que as imagens brincam com a expectativa do leitor ao destacarem elementos não usuais aos contos de fadas e subverterem convenções de livros ilustrados. As ilustrações agem, portanto, como potencializadoras do efeito revisionista presento no texto verbal, exercendo papel significativo para que a obra alcançasse tamanha notoriedade social e midiática.
A IMPORTÂNCIA DA LITERATURA INFANTIL NA COLETA DE DADOS E NA ESTIMULAÇÃO DE FALA INICIAL
Authors: Baia Maria de Fátima De Almeida
Published: July 2019

Neste estudo, apresentamos uma reflexão a respeito e relato do uso de literatura infantil na coleta de dados de desenvolvimento linguístico de crianças com desenvolvimento típico. Após apresentar a literatura sobre desenvolvimento da linguagem e sobre a literatura infantil, discutimos os métodos de coleta de dados infantis. Como leitor poderá ver, em geral, temos na literatura linguística regras de formato de transcrição, sem fazer menção às ferramentas utilizadas para a estimulação de fala da criança. Por essa razão e com intuito de mostrar a importância do uso desse tipo de literatura, apresentamos exemplos de sessões de coleta e estimulação de fala de crianças de dois a três anos do GEDEF, que ocorreram por meio da leitura e contação de estórias pelas crianças. No relato, descrevemos os aspectos linguísticos que foram trabalhados por meio de diferentes obras infantis.
A ESCRITA DE NARRATIVA NAS OBRAS DO PNLD DO ENSINO FUNDAMENTAL II: DESCRIÇÃO, ANÁLISE E PROPOSTAS
Authors: Gaignoux Aline De Azevedo
Published: July 2019

O eixo central da tese é explicitar como a produção de narrativas é trabalhada no Ensino Fundamental II, por meio da análise das obras do Programa Nacional do Livro Didático (PNLD) de 2017, abrangência até 2019, bem como comprovar a importância desse tipo de texto no amadurecimento da formação do sujeito escritor.
"Eles sempre têm um pouquinho de mágica”: o que dizem jovens leitores sobre o gênero literário conto de fadas
Authors: Ferreira da Rosa junior Paulo Ailton
Published: July 2019

Este artigo resulta de parte de uma pesquisa de mestrado em Educação realizada no âmbito do grupo História da Alfabetização, Leitura, Escrita e dos Livros Escolares (HISALES) vinculado ao Programa de Pós-graduação em Educação (PPGE) da Universidade Federal de Pelotas (UFPEL). Ele tem por objetivo analisar as declarações de sete jovens leitores reunidos em um grupo de discussão sobre contos de fadas, a fim de estabelecer aproximações e distanciamentos das suas concepções acerca deste gênero literário em relação ao que estudiosos do assunto postulam sobre ele. Pautam a discussão autores como Corso e Corso (2006), Coelho (2000) e Bettelheim (2014).
Bolsonaro, China and the Indo-Pacific: Challenges in Sight | Bolsonaro, China e o Indo-Pacífico: desafios à vista
Authors: Gabriel João Paulo Nicolini , Mandelbaum Henoch Gabriel , Sanches Siqueira Campos André , Carvalho Carlos Eduardo
Published: July 2019

This essay aims to focus on the initial perspectives about Brazil’s foreign policy and strategic thinking on how to cope with the rise of China’s economic and political might since the inauguration of Jair Bolsonaro’s administration. Bolsonaro demonstrates an interest in approach to the United States’ grievances against China. This paper advocate this strategy faces some hurdles: geographical and economic issues constrain countries such as Australia, India, and Japan to assume assertive instances against China, although they present uneasiness with the Chinese regional ambitions and Washington’s demands of a more active role in the Indo-Pacific. These countries compose with the United States the so-called Quadrilateral Security Dialogue, an initiative that seeks to facilitate their policy coordination towards the Indo-Pacific. However, Canberra, Tokyo, and New Delhi uphold a pragmatic strategy in order to maintain their special ties with the United States and to avoid skirmishes with Beijing.Keywords: Brazilian Foreign Policy; China; Indo-Pacific.RESUMOEste ensaio pretende focar nas perspectivas iniciais sobre a política externa e o pensamento estratégico do Brasil sobre como lidar com a ascensão do poder econômico e político da China desde a posse do governo de Jair Bolsonaro. Bolsonaro demonstra interesse em se aproximar das queixas dos Estados Unidos contra a China. Este artigo defende que essa estratégia enfrenta alguns obstáculos: questões geográficas e econômicas impedem que países como a Austrália, a Índia e o Japão assumam posições assertivas contra a China, embora apresentem desconforto com as ambições regionais chinesas e as exigências de Washington de um papel mais ativo no Indo-Pacífico. Esses países compõem, ao lado dos Estados Unidos, o chamado Diálogo Quadrilateral de Segurança, uma iniciativa que busca facilitar sua coordenação política em direção ao Indo-Pacífico. No entanto, Canberra, Tóquio e Nova Déli mantêm uma estratégia pragmática para manter seus laços especiais com os Estados Unidos e evitar confrontos com Pequim.Palavras-chave: Política Externa Brasileira; China; Indo-Pacífico.Recebido em: 11 fev.2019 | Aceito em: 2 mai.2019DOI: 0.12957/rmi.2019.40103
EDITORIAL
Authors: Karol Eduardo
Published: July 2019

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GESTÃO DEMOCRÁTICA E O PROCESSO DE EDUCAÇÃO INCLUSIVA: UMA RELAÇÃO POSSÍVEL?
Authors: Gonçalves Gomes Cintra Rosana Carla
Published: July 2019

Resumo: O artigo é  recorte da pesquisa que tem como investigação a relação da gestão democrática no processo de educação inclusiva. Discutimos no campo da Educação Especial na perspectiva da inclusão tecendo a seguinte problemática: qual a relação da gestão democrática no processo de educação inclusiva? Os procedimentos metodológicos  foram pesquisas em bancos de dissertações e teses no Brasil e análise do questionário intitulado “Inquérito para professores do Brasil que atuam na educação da infância e possuem crianças inclusas”. Como resultados, a dificuldade do trabalho escolar com a multiplicidade de sujeitos, dificuldades nas práticas e concepções  democráticas, tendo em vista a fragmentação do trabalho do professor.Palavras-chave: educação especial, inclusão, gestão democrática.
TEMPO DE INCERTEZAS: ELEMENTOS PARA UMA EDUCAÇÃO EMANCIPATÓRIA NA PERSPECTIVA DA TEORIA CRÍTICA DE T. W. ADORNO
Authors: Rocha Cleidson De Jesus
Published: July 2019

O presente ensaio discute a sensação de mal-estar enfrentada pela sociedade contemporâneo, resultante das frustrações de compartilhar uma mentalidade regressiva e pouco ilustrada, no sentido emancipatório.  Esse clima cultural geral é descrito por T. W. Adorno como uma regressão no tecido civilizatório e se manifesta aqui e acolá como um sintoma de que nem tudo está tão bem resolvido numa dada sociedade tecnologicamente avançada. Deste modo, o homem contemporâneo tornou-se vítima daquilo que ele mesmo provocou através de sua pretensão em dominar as coisas do mundo; regrediu em sua capacidade de ouvir e olhar a natureza como um todo repleto de mistérios nunca conhecidos plenamente. Diante deste quadro, o artigo apresenta as funções imperativas para a construção de uma autonomia democrática por meio de uma educação emancipatória, delineando o projeto educacional adorniano, que diz respeito aos esforços de investimento na formação crítica, que não premie a dor e que esclareça a respeito das possibilidades de que haja outras canalizações para a fúria represada das frustações cotidianas. Com este alerta, Adorno defende o seu principal projeto educaciconal: que Auschwitz não se repita.
Liver cancer
Authors: Peate Ian
Published: July 2019

To understand liver cancer and to provide care that is patient-centred, safe and effective, the healthcare assistant and the assistant practitioner (HCA and AP) need to know about the normal structure and function of the liver.

This article provides an overview and insight regarding primary liver cancer. A brief overview of the anatomy and physiology of the liver is provided, along with a discussion of liver cancer.

The signs and symptoms of the condition are described and treatment options discussed. The HCA and AP have a role to play as members of the multidisciplinary team who offer care to those people with liver cancer and their families.

A glossary of terms is provided, as well as multiple-choice questions to aid retention and recall, and 3 CPD reflective questions.
An overview of organ donation for support staff
Authors: Bleakley Gregory
Published: July 2019

The purpose of this article is to outline the importance of organ and tissue donation as a normal part of end-of-life care. Organ-donation statistics are presented, which highlight the need for more donors.

Many healthcare assistants (HCAs) and registered nurses are involved in the care of dying and deceased patients. This article intends to equip the HCA with knowledge of key terms and best practice concerning the organ- and tissue-donation process. Grief response is briefly explored and the importance of collaborative working is discussed. A framework for best practice is presented to enhance the likelihood of a positive donation outcome.
A neurological interpretation of crib-biting
Authors: Hale Catherine , Hemmings Andrew
Published: July 2019

Catherine Hale and Dr Andrew Hemmings discuss why we should change our views on horses that exhibit this behaviour
Imaging appearances of toxic and acquired metabolic encephalopathic disorders
Authors: Vamadevan Tharunniya , Howlett David , Filyridou Maria
Published: July 2019

Most imaging findings relating to toxic and acquired metabolic disorders follow a certain pattern with affinity to a specific topographic area, which can help narrow the differential diagnosis. This is especially useful when the clinical presentation can be variable and there is diagnostic uncertainty. Usually, there is bilateral symmetrical abnormality within the deep grey matter structures and the cerebral cortex because of the high metabolic activity and raised oxygen requirements in these areas. Magnetic resonance imaging, particularly diffusion weighted imaging and fluid-attenuated inversion recovery sequences, is very important in differentiating between various aetiologies in this group. Magnetic resonance imaging can be useful in demonstrating both acute and chronic damage, in evaluating treatment response and in disease prognostication. This pictorial review discusses the computed tomography and magnetic resonance imaging appearances of a spectrum of toxic and metabolic disorders observed in a district general hospital with reference to clinical presentation and imaging features that may allow diagnosis. This includes carbon monoxide poisoning, hypoglycaemia, non-ketotic hyperglycaemia, osmotic demyelination syndrome, posterior reversible encephalopathy syndrome, hypoxic ischaemic encephalopathy, the syndrome of delayed post-hypoxic leukoencephalopathy, hepatic encephalopathy and cocaine toxicity.
Combined PET/MRI in brain glioma imaging
Authors: Almansory Karar O , Fraioli Francesco
Published: July 2019

Gliomas are the most common primary brain tumours in children and adults, consisting of a heterogeneous group of neoplastic diseases arise from the supporting cells of the CNS (glial cells). Their histopathological and molecular characteristics vary considerably as do their management and prognosis. Conventional gadolinium-enhanced magnetic resonance imaging (MRI) is considered the primary imaging modality for initial work up and follow up of patients with gliomas, although it has some limitations, especially in differentiating high from low grade tumours and in distinguishing disease recurrence from post-therapy changes. Hybrid positron emission tomography (PET)/MRI is a relatively novel tool that combines MRI sequences with metabolic information from PET, and therefore different PET radiotracers, in a single scan. This article discusses the main advantages and disadvantages of combined PET/MRI compared to other conventional or more widely available imaging tools, such as MRI or combined positron emission tomography–computed tomography. The main uses of PET/MRI and the most commonly used PET radiotracers in providing diagnostic, prognostic and predictive information in patients with glioma are covered.
Caring for your migrant patients and providing for their needs
Authors: Crawshaw Alison , Hornigold Rachael , Mandal Sema , Campos-Matos Ines
Published: July 2019

Most migrants who come to the UK are young and healthy adults, but some have specific health needs that may be less familiar to health practitioners. This article describes migration patterns and highlights key points for migrant-sensitive care in general practice

The UK has a long history of migration and in 2018 an estimated 14% of the population were born overseas. As international migration and displacement continue to rise, understanding how to care for migrant patients is of increasing importance for health professionals. This article describes migration trends in the UK and suggests considerations for care relating to key aspects of migrant health in general practice, including migrants' entitlements to the NHS, immunisation, infectious disease surveillance, testing and treatment, mental health, human trafficking and sociocultural considerations. It also highlights useful resources.
Social prescribing in practice: community-centred approaches
Authors: Howarth Michelle , Burns Liz
Published: July 2019

More people are living longer with multimorbidities, many of which are handled in general practice. Michelle Howarth and Liz Burns highlight the contribution that general practice nurses can make to providing person-centred approaches to improving health and wellbeing

The NHS Long Term Plan recognised the need to understand that ’what matters to someone’ is not the same as ‘what's the matter with someone’. Conversations that focus on what is the matter with someone typically draw out the patient's needs, with assessment and care planning based on classic principles of pathogenesis and accompanying clinical solutions. Conversations that consider what matters to someone draw out a person's individual assets and what is important to them, with personalised care and support planning based on principles of salutogenesis and non-medical solutions, such as social prescribing. This article explores the pivotal role that practice nurses have in maximising their impact on personalised care and population health for all, including for people living with long-term physical and mental health conditions. It highlights the unique contribution that practice nurses can make in strengthening community-centred approaches to health and wellbeing in primary care.
General Practice Nurse Conference 2019
Authors: Brown Debbie
Published: July 2019

The GPN Conference, organised by Practice Nursing Editor-in-Chief Debbie Brown, hosted several speakers and discussed some of the most relevant issues facing the profession today, including leadership, sexual health and embracing Primary Care Networks
Analyzing risk factors for recurrence of developmental coxa vara after surgery
Authors: Bian Z. , Xu Y. J. , Guo Y. , Fu G. , Lyu X. M. , Wang Q. Q.
Published: July 2019

Purpose

To evaluate the risk factors for developmental coxa vara (DCV) recurrence following valgus osteotomy of the proximal femur.

Methods

We retrospectively reviewed records of 32 DCV patients (46 hips) treated surgically (2005 to 2012). Recurrence-related factors, including age at initial surgery, side, sex, fixation methods, diagnosis of coxa vara, premature capital femoral physeal closure and postoperative Hilgenreiner epiphyseal (HE) angle, head-shaft (HS) angle, medial femoral offset and posterior slope angle (PSA) were analyzed.

Results

At 4.7-year mean follow-up, 12 hip deformities recurred (26%). Postoperative HE angle > 41° and negative offset were statistically significant univariate and multivariate risk factors for the deformity recurrence. Increased PSA was common preoperatively, which accounted for 59% of hips. Postoperative PSA > 20° was associated with a high recurrence rate in the univariate analysis. Age was another univariate risk factor for the recurrence. Recurrence rate was 52% in the < 6.5-year age group versus 4% in the > 6.5-year age group. Other factors were not statistically significantly related to recurrence.

Conclusion

DCV is a 3D deformity. To prevent recurrence, HE angle should be restored to < 41° in the coronal plane. Sagittal malalignment (abnormal PSA) should be corrected concurrently, so that, the direction of surgical correction is along the true deformity plane. During valgus osteotomy, the distal fragment should be lateralized to maintain a normal mechanical axis.

Level of Evidence

IV
Whole-transcriptome sequencing of knee joint cartilage from osteoarthritis patients
Authors: Li H. , Yang H. H. , Sun Z. G. , Tang H. B. , Min J. K.
Published: July 2019

Objectives

The aim of this study was to provide a comprehensive understanding of alterations in messenger RNAs (mRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) in cartilage affected by osteoarthritis (OA).

Methods

The expression profiles of mRNAs, lncRNAs, and circRNAs in OA cartilage were assessed using whole-transcriptome sequencing. Bioinformatics analyses included prediction and reannotation of novel lncRNAs and circRNAs, their classification, and their placement into subgroups. Gene ontology and pathway analysis were performed to identify differentially expressed genes (DEGs), differentially expressed lncRNAs (DELs), and differentially expressed circRNAs (DECs). We focused on the overlap of DEGs and targets of DELs previously identified in seven high-throughput studies. The top ten DELs were verified by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) in articular chondrocytes, both in vitro and in vivo.

Results

In total, 739 mRNAs, 1152 lncRNAs, and 42 circRNAs were found to be differentially expressed in OA cartilage tissue. Among these, we identified 18 overlapping DEGs and targets of DELs, and the top ten DELs were screened by expression profile analysis as candidate OA-related genes. WISP2, ATF3, and CHI3L1 were significantly increased in both normal versus OA tissues and normal versus interleukin (IL)-1β-induced OA-like cell models, while ADAM12, PRELP, and ASPN were shown to be significantly decreased. Among the identified DELs, we observed higher expression of ENST00000453554 and MSTRG.99593.3, and lower expression of MSTRG.44186.2 and NONHSAT186094.1 in normal versus OA cells and tissues.

Conclusion

This study revealed expression patterns of coding and noncoding RNAs in OA cartilage, which added sets of genes and noncoding RNAs to the list of candidate diagnostic biomarkers and therapeutic agents for OA patients. Cite this article: H. Li, H. H. Yang, Z. G. Sun, H. B. Tang, J. K. Min. Whole-transcriptome sequencing of knee joint cartilage from osteoarthritis patients. Bone Joint Res 2019;8:290–303. DOI: 10.1302/2046-3758.87.BJR-2018-0297.R1.
РОССИЙСКИЙ И ЗАРУБЕЖНЫЙ ОПЫТ ПРИМЕНЕНИЯ ИНФОРМАЦИОННО-КОММУНИКАЦИОННЫХ ТЕХНОЛОГИЙ В РАБОТЕ НЕКОММЕРЧЕСКИХ ОРГАНИЗАЦИЙ
Authors: Косыгина Ксения Евгеньевна
Published: July 2019

Отличительной особенностью современного этапа развития общества является усиление влияния интернета и информационно-коммуникационных технологий на все сферы жизни. Деятельность некоммерческих организаций не является исключением. Настоящая статья посвящена исследованию вопросов применения информационно-коммуникационных технологий некоммерческими организациями (далее - НКО) в России и за рубежом. Приводятся результаты международного социологического опроса, обобщающего новейшие тенденции работы в цифровой среде НКО из 164 стран мира. Представлены результаты исследования по использованию Интернет-ресурсов российскими некоммерческими организациями на примере Вологодской области. Выявлено, что НКО в России существенно отстают от зарубежных коллег в использовании современных информационных ресурсов. В заключении к статье предложено несколько инструментов по эффективному применению информационно-коммуникационных технологий некоммерческими организациями.
МИГРАЦИОННЫЙ ПРОЦЕСС В УСЛОВИЯХ ГЛОБАЛИЗАЦИИ: ХАРАКТЕРНЫЕ ОСОБЕННОСТИ И ОСНОВНЫЕ ТЕНДЕНЦИИ
Authors: Ульмасов Рахмон Ульмасович
Published: July 2019

Исследуется процесс становления и развития международной миграции населения и демографии. Анализируется широкий спектр текущих и перспективных проблем миграции, взаимодействие в международных организациях. Важное место уделено вопросам возрастающего миграционного движения миллионов землян, современным закономерностям, которые его определяют, последствиям, которые влечет за собой международная миграция населения для республик Центральной Азии, какова должна быть миграционная политика на современном этапе.
FERTILITY PRESERVATION: Freezing of ovarian tissue and clinical opportunities
Authors: Yding Andersen C , Mamsen L S , Kristensen S G
Published: July 2019

Ovarian tissue cryopreservation (OTC) is mainly used for fertility preservation in girls and women facing a gonadotoxic treatment. If the woman subsequently becomes menopausal, the ovarian tissue may be transplanted to regain ovarian function, including fertility. The method was developed more than two decades ago and today thousands of women worldwide have undergone OTC. Fewer than 500 patients have had tissue transplanted and close to 100% of those regain ovarian function. Several technical aspects of OTC are now becoming more established, including high quantitative follicle survival, defining the size of the tissue resulting in optimal tissue revascularisation and follicle loss resulting from transport of ovarian tissue prior to freezing. We have used OTC to safeguard fertility in patients with genetic diseases, which for some diagnoses is purely experimental, as no transplantations is yet been performed. Usage of OTC beyond fertility is now also being considered; here, the endocrine function of follicles is the focus. It has been suggested that ovarian tissue stored in the reproductive years may be used to avoid premature ovarian insufficiency (POI) when there is a familial disposition or to postpone menopause in patients with an increased risk of osteoporosis or cardiovascular diseases. The benefit of OTC beyond fertility requires, however, actual clinical studies. The current review includes several recent technical aspects with contributions from Denmark building on some of the early work by Roger Gosden.
Characterization of dendritic cell (DC)-10 in recurrent miscarriage and recurrent implantation failure
Authors: Liu Su , Wei Hongxia , Li Yuye , Diao Lianghui , Lian Ruochun , Zhang Xu , Zeng Yong
Published: July 2019

During pregnancy, the maternal immune system must tolerate the persistence of semi-allogeneic fetus in the maternal tissue. Inadequate recognition of fetal antigens may lead to pregnancy complications, such as recurrent miscarriage (RM) and recurrent implantation failure (RIF). Dendritic cells (DCs) are key regulators of protective immune responses and the development and maintenance of tolerance. Regarding that DCs are important in the establishment of immune tolerance in human pregnancy, it would be important to study the microenvironment in which DCs reside or are activated may affect their functions toward tolerance rather than active immune response. IL-10 plays a critical role in the maintenance of normal pregnancy, and the increased production of IL-10 is associated with successful pregnancy. In this study, we provide an in-depth comparison of the phenotype and cytokine production by DC-10 and other DC subsets, such as iDC and mDC. CD14+ monocyte-derived DCs were differentiated in the presence of IL-10 (DC-10) in vitro from ten normal fertile controls, six RM women and seven RIF women, and characterized for relevant markers. DC-10 was characterized by relatively low expression of costimulatory molecule CD86, as well as MHC class II molecule HLA-DR, high expression of tolerance molecules HLA-G, ILT2, ILT4 and immunosuppressive cytokine IL-10, but produced little or no proinflammatory cytokines, such as TNF-α, IL-6 and IL-12p70. Our study provides a better understanding of the phenotypical properties of DC-10, which may participate in the complex orchestration that leads to maternal immune tolerance and homeostatic environment in human pregnancy.
TEORÍA BÁSICA Y APLICACIONES DE LAS PROPIEDADES EMERGENTES DE LA SOCIEDAD COMO UN SISTEMA COMPLEJO
Authors: Araujo Soria Sebastián
Published: July 2019

En este artículo presenta la teoría básica para estudiar las sociedades humanas como sistemas complejos. Se comienza por mostrar los axiomas de un sistema social así como las características generales de los sistemas complejos. La complejidad de los sistemas sociales se formaliza usando el concepto de la entropía no extensiva de Tsallis. Esta entropía se deduce a partir de la redefinición de la función logarítmica como el logaritmo-q. Con esta entropía se analizan las propiedades emergentes en la física de la sociedad usando un ejemplo de aplicación con datos del ingreso por hogares y la relación de la sociedad con todo el universo.
Analisis Psikomotorik Halus Siswa Ditinjau dari Keterampilan Menggambar Anak Usia Dasar SD
Authors: Rizqia Maulida , Iskandar Wahyu , Simangunsong Nurzakiah , Suyadi Suyadi
Published: July 2019

This article has a purpose to find out the development of the elementary student psychomotor which carried out in SDN Demangan, Yogyakarta. The development is related to the activity using fingers to do a variety of activities such as drawing. This research used descriptive qualitative method and to quest the data it used observation, interviews and documentation method by observing the development of the student psychomotor. The focus of this research is on finding: 1) how the development of the student psychomotor whether it is reached or not, 2) how the factors that affect the development of the student psychomotor, 3) how the solution to the development of the student psychomotor. The result are: 1) the development of the student psychomotor which is reached and not, it is marked by the coordination of nerve and well fingers movement, so the student obtains the result of the good drawing, 2) the factor that affects the development of the student psychomotor, there are two factors; internal and external. Internal factor is influenced from genetic factor and the external is from the surrounding environment to support the development, 3) the solution is to anticipate the problems of the development of the student psychomotor by seeking the training and giving guidance toward the student to motivate them achieving the development.Keywords: Development, psychomotor, children, elementary school
IMPLEMENTASI KEBIJAKAN MENTERI AGRARIA DAN TATA RUANG TENTANG PERCEPATAN PELAKSANAAN PENDAFTARAN TANAH SISTEMATIS LENGKAP DI KOTA BANDUNG
Authors: Hidayat Asep , Engkus Engkus , Afra. N Hasna
Published: July 2019

This research aims to know the strategy of the Government in the implementation of the programme of PTSL and to find out how big a success rate of Program execution PTSL in Bandung. The results showed that the Government strategy of Bandung Bandung in BPN through program implementation through the preparation of PTSL ripe includes socialization, the determination of the location, planning effort, and the establishment of the Committee ajudikasi acceleration, training and outreach. The success rate of execution of PTSL in Bandung from the target amount of the targeted land certificate 93,000 just 7,234 certificates or reached only 7.78% of the data that researchers get. This is caused by a number of working groups, the situation is not comparable with the volume so that the targets set in the achievement of the targets still not be met.
Feminisme Indonesia dalam Lintasan Sejarah
Authors: Aliyah Ida Hidayatul , Komariah Siti , Chotim Endah Ratnawaty
Published: July 2019

This article studies the opinion of Muslim feminists on Islam and women empowerment. Using Indonesian history as the reference of being colonized, analytically the writer shows how these cultural and political problems placed Indonesian Muslim women into a kind of continuing struggle of independence. Having a careful consideration of Indonesian history and culture, the writer’s final idea was that Islam has a meeting point with feminism. It is suggested, then, that based on Indonesian Muslim history it should be acknowledged that Islam is compatible with the idea of progress for women.
PENERIMAAN MASYARAKAT SEBAGAI HASIL SINERGI HUMAS DAN MEDIA MASSA
Authors: Sjoraida Diah Fatma , Rizal Edwin
Published: July 2019

Penelitian ini membahas bagaimana humas dari perusahaan energi dapat memanfaatkan media massa sehingga keberadaannya dapat diterima oleh masyarakat. Penelitian ini dilakukan di suatu desa di Kabupaten Bekasi yang merupakan daerah pertanian di pinggiran Kota Jakarta. Secara umum, penelitian ini mendasarkan pada metode deskriptif dan kualitatif. Hasil penelitian menunjukkan bahwa kehidupan sosial ekonomi di desa tersebut berubah namun masyarakat dapat menerimanya. Adapun faktor-faktor yang menyebabkan diterimanya perusahaan tersebut adalah karena pihak humas dari perusahaan tersebut sambil bekerja sama dengan pihak media massa melakukan strategi dengan meluncurkan program csr, menyerap tenaga kerja, dan penyadaran akan orientasi ke masa depan kepada masyarakat sekitar. Walaupun demikian, masyarakat masih mengeluhkan kenyamanan hidup di sekitar pabrik tersebut.
Demokrasi Sosial dalam Pemikiran Paul Feyerabend
Authors: Widarda Dodo
Published: July 2019

This article reevaluates Feyerabend’s thought in formatting social order based on his concept of Anything Goes. The discussion is a new challenge for social studies in the new circumstances and time. By taking Feyerabend’s books this study describes and analyzes the format of Feyerabend’s thought, what are being rejected by him, and what is being proposed by him in order to develop democracy in the community. By his effort, it is clear that Feyerabend places democracy as his fundamental reference for his idea of intellectual movement. Finally, this article contextualizes Feyerabend’s thought with what being happened in our time.
New analogues of the Filbert and Lilbert matrices via products of two k-tuples asymmetric entries
Authors: KILIÇ Emrah , ÖMÜR Neşe , KOPARAL Sibel
Published: July 2019

In this paper, we present new analogues of the Filbert and Lilbert matrices via products of two $k$-tuples asymmetric entries consist of the Fibonacci and Lucas numbers. We shall derive explicit formulae for their $LU$-decompositions and inverses. To prove the claimed results, we write all the identities to be proven in $q$-word and then use the celebrated Zeilberger algorithm to prove required $q$-identities.
Closing Editorial: Conversations in healthcare education
Authors: Marshall Stuart , Kiegaldie Debra
Published: July 2019

This article was migrated. The article was marked as recommended. The theme coincided with the 8thInternational Clinical Skills Conference held in Prato Italy, May 2019. The conference focused on putting the spotlight on conversations in healthcare and we were highly successful in achieving this aim by generating much discussion, debate and dialogue amongst our conference delegates. The conference is known for its informality, friendliness and ability to bring people together as a community of practice and this year was no exception. The conversations on twitter alone was unprecedented with over three million impressions over the period of the conference. This is a truly remarkable number given that the conference is limited to only 250 delegates because of the size of the venue. Whilst the conference did not generate as many paper submissions to MedEdPublish as we would have liked, the five papers submitted were noteworthy and included practical tips to use for teaching intrinsic skills to physicians (LaFleur et al., 2019), implementing a collaborative social media platform in obstetrics and gynaecology (O'Sullivan, Janssens and Warhurst, 2019) , and developing consultation skills for medical students (Andersson et al., 2019).Nevertheless, we believe this is the first experiment in true 360-degree scientific peer review. A system where manuscripts published on the journal's website before a conference can be explained in conference presentations, questions asked, discussed on social media and finally reviews published alongside the paper on the website. Such a model must surely be beneficial for disseminating new research and ensuring it is of the highest standard.Conversations in healthcare today continue to be of great importance to the future of clinical education and for developing health professionals with the skills needed for person-centred care and we look forward to continuing this work into the future.
Economic appraisal of hybrid solar–biomass thermophotovoltaic power generation
Authors: Hussain Choudhury Mohammad Iftekhar , Duffy Aidan , Norton Brian
Published: July 2019

The techno-economic parameters that influence the commercial deployment of hybrid thermophotovoltaic (TPV) solar power generation are determined using annual system simulations. It has been found that a TPV cell price of €5/cm2 or less together with a TPV operating temperature under 800°C is required for a hybrid solar–biomass TPV power plant to be economically competitive with the state-of-the-art hybrid solar–biomass Rankine cycle power plants.
Chloride resistance and binding capacity of cementitious materials containing high volumes of fly ash and slag
Authors: Fu Chuanqing , Ling Yifeng , Ye Hailong , Jin Xianyu
Published: July 2019

A systematic study on the chloride penetration resistance and binding capacity of cementitious materials containing varying proportions of low-calcium fly ash or blast-furnace slag is presented. The results show that a larger water/binder ratio of cementitious materials can enhance its binding capacity but reduce chloride resistance regardless of binder type. At a given water/binder ratio, the chloride-binding capacity of cementitious binder plays an important role in its chloride resistance in the saturated condition. Fly ash can improve the chloride resistance and binding capacity of cementitious binders with the gradual increase of fly ash replacement ratio up to 70%. However, slag-blended cementitious binder shows the highest chloride resistance and binding capacity when the slag replacement ratio is about 40%. A higher volume of slag can result in a decline of chloride resistance and binding capacity. In addition, the Freundlich isotherm provides the best fit for describing the chloride-binding capacity of cementitious materials, regardless of water/binder ratio and binder type.
GPRC5b Modulates Inflammatory Response in Glomerular Diseases via NF-κB Pathway
Authors: Zambrano Sonia , Möller-Hackbarth Katja , Li Xidan , Rodriguez Patricia Q. , Charrin Emmanuelle , Schwarz Angelina , Nyström Jenny , Wernerson Annika Östman , Lal Mark , Patrakka Jaakko
Published: July 2019

Significance Statement

Mechanisms regulating inflammatory response in glomeruli are poorly understood. In this study, the authors identify a novel G protein–coupled receptor (GPCR) that is highly enriched in podocytes, called Gprc5b. Gprc5b is upregulated in common human glomerular diseases, such as IgA nephropathy, lupus nephritis, and diabetic nephropathy. Studies in knockout animals and human podocytes grown in culture show that Gprc5b promotes glomerular inflammation via regulation of NF-κB pathway in podocytes. Upregulation of Gprc5b in human diseases suggests that this mechanism may play an important role in the pathogenesis of common glomerulopathies.

Background

Inflammatory processes play an important role in the pathogenesis of glomerulopathies. Finding novel ways to suppress glomerular inflammation may offer a new way to stop disease progression. However, the molecular mechanisms that initiate and drive inflammation in the glomerulus are still poorly understood.

Methods

We performed large-scale gene expression profiling of glomerulus-associated G protein–coupled receptors (GPCRs) to identify new potential therapeutic targets for glomerulopathies. The expression of Gprc5b in disease was analyzed using quantitative PCR and immunofluorescence, and by analyzing published microarray data sets. In vivo studies were carried out in a podocyte-specific Gprc5b knockout mouse line. Mechanistic studies were performed in cultured human podocytes.

Results

We identified an orphan GPCR, Gprc5b, as a novel gene highly enriched in podocytes that was significantly upregulated in common human glomerulopathies, including diabetic nephropathy, IgA nephropathy, and lupus nephritis. Similar upregulation of Gprc5b was detected in LPS-induced nephropathy in mice. Studies in podocyte-specific Gprc5b knockout mice showed that Gprc5b was not essential for normal development of the glomerular filtration barrier. However, knockout mice were partially protected from LPS-induced proteinuria and recruitment of inflammatory cells. Mechanistically, RNA sequencing in Gprc5b knockouts mice and experiments in cultured human podocytes showed that Gpr5cb regulated inflammatory response in podocytes via NF-κB signaling.

Conclusions

GPRC5b is a novel podocyte-specific receptor that regulates inflammatory response in the glomerulus by modulating the NF-κB signaling pathway. Upregulation of Gprc5b in human glomerulopathies suggests that it may play a role in their pathogenesis.
Hısn-ı Mansur Mütesellimi Abdi Ağa'nın Hısn-ı Mansur ve Behisni Kazalarındaki Vakıfları
Authors: TUNÇ Muhammet Nuri
Published: July 2019

Türk ve İslam devletlerinde toplumsal,
iktisadî ve hukukî yönleriyle önemli bir müessese olan vakıflar, Osmanlı
Devleti'nde de toplumsal, iktisadî ve hukukî hayatta önemli rol oynamıştır. Vakıflar
başta padişahlar olmak üzere hanedan üyeleri, yüksek rütbeli devlet adamları ve
toplumun zengin ve seçkin kişileri tarafından kurulmuştur. 16. yüzyılda Osmanlı
hâkimiyetine giren Adıyaman'da da Osmanlı genelinde olduğu gibi bey, paşa,
şeyh, ağa unvanlı toplumun zengin, güç sahibi ve seçkin kişileri tarafından birçok
vakıf kurulmuştur. Abdi Ağa'nın Adıyaman'da kurmuş olduğu vakıflar da bu duruma
güzel bir örnek teşkil eder. Bu çalışmada, Abdi Ağa'nın 18. yüzyıl sonlarında
Hısn-ı Mansur (Adıyaman) ve Behisni (Besni) kazalarında kurmuş olduğu vakıflar
ve bu vakıflara ait vakfiyeler incelenmiştir. Konunun daha iyi anlaşılması için
vakıf müessesesi ile ilgili birtakım bilgiler verildikten sonra Abdi Ağa'nın
yaptırmış olduğu mektep, medrese ve camilerdeki görevliler ve vakıflara ait
vakfiyeler hakkında bilgi verilmiştir.
The Effect of the Current Expected Credit Loss Standard (CECL) on the Timing and Comparability of Reserves
Authors: Chae Sarah , Sarama Robert F. , Vojtech Cindy M. , Wang James
Published: July 2019

CECL, the new credit loss provisioning standard, is intended to promote proactive provisioning as loan loss reserves must incorporate forward-looking assumptions. We study how one assumption-expectations about future house prices-affects the size and timing of provisions for residential mortgage portfolios. While provisions under CECL are generally less pro-cyclical compared to the incurred loss standard under various forecasts and measures of pro-cyclicality, CECL may complicate the comparability of provisions across banks and time. Market participants will need to disentangle the degree to which variation in provisions across firms is driven by underlying risk versus idiosyncratic differences in forecasting methods.
The Effects of Bank Capital Buffers on Bank Lending and Firm Activity: What Can We Learn from Five Years of Stress-Test Results?
Authors: Berrospide Jose M. , Edge Rochelle M.
Published: July 2019

We use bank-firm matched data from regulatory filings (FR Y-14) to study how the capital buffers that large U.S. banks must satisfy to "pass" the quantitative component of the Federal Reserve's CCAR stress tests impact banks’ C&I lending and firms' C&I loan volumes, overall debt, investment spending, and employment. We find that larger stress-test capital buffers lead to material reductions in bank C&I lending. A 1 p.p. larger capital buffer results in a 2 p.p. lower (four-quarter) growth rate of utilized loans and a 1½ p.p. lower growth rate of committed loans. The effects on firm loan volumes are larger, when we look at the loans that firms obtain from banks subject to stress tests. A firm that borrows from banks that on a weighted-average basis face a 1 p.p. larger stress-test capital buffer, experiences a 4 p.p. lower rate of growth in utilized loans and a 3 p.p. lower rate of growth of committed credit lines. However, when we consider firms’ overall debt volumes we find no impact of higher stress-test capital buffers, suggesting that firms can find other sources of credit to substitute for the reduction in loans that they face from banks subject to stress tests. We also find that firm investment and employment are largely unaffected by the capital buffers implied by stress tests. Because in the U.S. the consequences for banks of not meeting their stress-test capital buffers are similar to those of not satisfying an activated countercyclical capital buffer (CCyB), our findings are informative for the effects of the CCyB. Our results suggest that activating the CCyB in the U.S. would likely reduce the lending of the banks to which the CCyB applies, but would likely not impact the overall debt volumes, investment, and employment of the firms that borrow from these banks.
Application of Decision Tree Analysis for Supporting Tourism Policy Decision Making : Empirical Analysis of Tourism Development Policy Priorities
Authors:   The Tourism Sciences Society Of Korea, Park Gyung-Yeol , Lee Hyun-Ju
Published: July 2019

Tourism policy decision making is a series of processes to select the best policy alternatives by comparing and evaluating policy alternatives. The processes are complicated and it is not easy to explain and make them understood easily. Tourism policy decisions appear as priorities of policy alternatives, and various judgment criteria act compositely in the prioritization. This study empirically applied decision tree analysis as one of methods to support tourism policy decision making and presented the usefulness. To this end, decision tree analysis in the prioritization of tourism development policy was empirically analyzed. First, decision tree analysis is useful for understanding the processes and results of tourism policy decision making as it structurally presents and schematizes the processes and results. Second, decision tree analysis facilitates the understanding of major variables that affect the priorities of tourism policies and quantifies the results so that the degrees of effects can be identified. Third, it enables the comparison between observed values and predicted values in the prioritization in tourism policy decision making so that the results can be used as useful data in decision making if variables that facilitate comparison and judgment are clearly identified.
The Role of Storytelling Contents to Influence Place Attachment : The Case of Imperial Eunuchs’ Burial Ground in Mount Choan
Authors:   The Tourism Sciences Society Of Korea, Lee Ryang-Suk , Cho Mi-Hea
Published: July 2019

The conceptual definition and effect of storytelling contents are presented by identifying each construct of storytelling based of the existing literature reviews. In addition to the contents of storytelling applied to tourism resources, the effects of contents are theoretically and conceptually discussed. The purposes of this study are to investigate the relationships between the effects of contents and place attachment as well as between the components of storytelling and the effects of contents. Based on the theoretical bases of previous research, the components of storytelling are identified as creativity, descriptiveness, and metaphor. Also, the constructs of the contents effects are identified as image association, presence, understanding, and interesting. In the results of the research hypotheses, the creativity, descriptiveness, and metaphor of storytelling have significantly positive relationships with image association, presence, understanding, and interesting of contents effects. Finally, the mediating effects of contents effects excluding understanding are significantly related to storytelling and place attachment. In conclusion, the implications for storytelling contents are discussed for the marketing and promotion strategies.
How to Culture Human Bronchial Epithelial Cells as Airway Organoids v1
Authors: Technologies Stemcell
Published: July 2019

Human bronchial epithelial cells (HBECs) are typically cultured at the air-liquid interface (ALI) to functionally recapitulate the human airway. ALI cultures are formed by plating primary HBECs onto porous cell culture inserts and allowing the cells to achieve confluence prior to removing the culture medium from the apical surface of the cells. However, the requirement of porous culture inserts can limit the application of ALI culture to smaller scale experiments, thus largely precluding high-throughput drug screening of differentiated epithelial cultures. Alternatively, HBECs may be cultured and differentiated as spherical aggregates, providing a means for high-throughput study of the differentiated human airway. This protocol describes a method for the culture of differentiated HBECs as spherical structures known as broncospheres or airway organoids.