bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel genomic risk loci and improved prediction for treatment-resistant schizophrenia are revealed by leveraging polygenic overlap with body-mass index
Authors: O'Connell Kevin , Koch Elise , Lenk Hasan , Akkouh Ibrahim , Hindley Guy , Jaholkowski Piotr , Smith Robert , Holen Børge , Shadrin Alexey , Frei Oleksandr , Smeland Olav , Steen Nils Eiel , Dale Anders , Molden Espen , Djurovic Srdjan , Andreassen Ole
Published: October 2022

Treatment resistant schizophrenia (TRS) is characterized by repeated treatment failure with antipsychotics. A recent genome-wide association study (GWAS) of TRS showed a polygenic architecture, but no significant loci were identified. Clozapine is shown to be the superior drug in terms of clinical effect in TRS; at the same time it has a serious side effect profile, including weight gain. Here, we sought to increase power for genetic discovery and improve polygenic prediction of TRS, by leveraging genetic overlap with Body Mass Index (BMI). We analysed GWAS summary statistics for TRS and BMI applying the conditional false discovery rate (cFDR) framework. We observed cross-trait polygenic enrichment for TRS conditioned on associations with BMI. Leveraging this cross-trait enrichment, we identified 2 novel loci for TRS at cFDR < 0.01, suggesting a role of MAP2K1 and ZDBF2. Further, polygenic prediction based on the cFDR analysis explained more variance in TRS when compared to the standard TRS GWAS. These findings highlight putative molecular pathways which may distinguish TRS patients from treatment responsive patients. Moreover, these findings confirm that shared genetic mechanisms influence both TRS and BMI and provide new insights into the biological underpinnings of metabolic dysfunction and antipsychotic treatment.
New composite based on recycled dust wood for fast neutrons and gamma rays shielding
Authors: Elashmawy Mostafa M. , Abdelwahab Nesreen R. , Abdallah Noha
Published: October 2022

Composite with 6 different concentrations of Dust Wood, B2O3, and Styrene-Butadiene Rubber were prepared and tested for fast neutrons and gamma rays shielding using a narrow collimated beam from 241Am-Be and 137Cs sources respectively. Composite of 50% Dust Wood, 25% Styrene-Butadiene Rubber and 25% B2O3 is found to have the highest shielding effectiveness for both neutrons and gamma radiation. Results were then compared with those obtained theoretically for borated polyethylene at the same concentrations of boron. The new composite is found to be about 29% less effective for neutron shielding and about 15% more effective in case of gamma shielding. In a standard case study; door shielding in radiotherapy bunker; a thickness of 4.5 cm of the proposed composite could replace 3.2 cm of borated polyethylene (B = 5% wt). The new composite has two major advantages: first, it recycles Dust Wood as an unwanted waste, which helps protect the environment, and second, it provides a locally produced alternative to pricey BPE at a cost that is between 60% and 70% less than the average price worldwide.
Determination of Orbital Periastron and Apastron Points and Their Time Values on h+ and hX Gravitational Waveforms in Eccentric Binary Systems
Authors: Özçelik Hakan
Published: October 2022

In this study, we analyze the gravitational wave polarization h+ and h× waveforms according to the true and eccentric anomalies for a binary system with eccentricity. For such a binary system, using the h+ and h× waveforms according to the true and eccentric anomalies, we plot graphs according to different values of eccentricity e and show the locations of orbital periastron and apastron points on waveforms. In the next step, taking into account the orbital inclination angle i, argument of periastron ω0 and longitude of the ascending node Ω0, according to any observer, we derive h+ and h× waveforms more comprehensively with respect to the true anomaly of a binary system with eccentricity. As an example, we apply these latter derived expression to PSR B1534+12 and PSR B1913+16 binary pulsar systems. Using current data of these binary pulsar systems and the values of ω0 and Ω0 parameters through literature (and also used arbitrary values for these parameters), we obtain different h+ and h× waveforms. Finally, by using the h+ waveforms generated for these binary pulsar systems, we obtain the times for the periastron and apastron points and the time to arrive from the periastron to the apastron (t1) and the time arrive from the apastron to periastron (t2), and then we conclude the study by discussing these results.
Deformation characteristics, mechanisms, and dominant factors involved in rainfall-hydrodynamic pressure landslides: case study of the Sanmendong landslide in the Three Gorges Reservoir
Authors: Fan Zhihong , Wang Shimei , Wang Li , Guo Fei , Huang Junjie , Li Xiaowei
Published: October 2022

A 16-year surface macroscopic survey and GPS monitoring results from the Sanmendong landslide in the Three Gorges Reservoir Area have demonstrated that the deformation degree of the landslide is distinctly correlated with rainfall and fluctuations in reservoir levels. In this study, the seepage field and stability coefficient of Sanmendong landslide deformation under the conditions of rainfall were estimated, and fluctuations in the reservoir water level and their coupling effects were simulated and calculated, respectively. The simulation results revealed that as the water level rises, the seepage force is directed to the inside of the slope, thus creating conditions that bolster landslide stability. However, when the reservoir water level drops or rainfall occurs, the seepage force is directed to the outside of the slope, thereby hindering landslide stability. GPS monitoring data and the correlation between reservoir water level fluctuations, rainfall, and landslide deformation were further analyzed. The analysis revealed a positive correlation between rainfall and the displacement rate at monitoring point ZG361, with a high grey correlation degree (0.761). However, the correlation between the rate of fluctuating reservoir water levels and the displacement rate at monitoring point ZG361 was insignificant. The stability calculation demonstrated that under normal Three Gorges Reservoir operation, a decrease in water level only decreases the stability coefficient by < 1%, whereas the heavy rainfall process decreases the stability coefficient by > 10%. The above results prove that the rainfall is the primary driver governing Sanmendong landslide deformation.
WITHDRAWN: Investigating the miRNA of the Chinese herb Gecko on the cross-species regulation network of hepatocellular carcinoma
Authors: Li Zhaosheng , Zhao Jing , Tong Dongchang , Yi Chun , Deng Zhe , Huang Zhen , Wuang Yongli , Tian XueFei
Published: October 2022

Gecko is a traditional Chinese herb that has been extensively documented as a treatment for various illnesses, including cancer, for thousands of years in ancient Chinese literature. The development of Chinese medicinal preparations and the role of small molecule active ingredients in Chinese medicine have recently emerged as new research hotspots. However, the potential cross-species regulatory mechanisms of microRNAs (miRNAs) from Gecko components in hepatocellular carcinoma (HCC) are not fully understood. In this study, we isolated and extracted total RNA from Chinese herbal Gecko tablets after powdering and screened the Gecko miRNA expression dataset after high-throughput sequencing to compare with the survival-related differentially expressed miRNA dataset in human HCC to identify new Gecko and HCC survival-related miRNA-mRNA regulatory networks. The miR-100-5p, miR-99a-5p, and miR-101-3p were identified as critical miRNAs for the role of Geckos in human HCC. Stepwise prediction and validation, nine downstream mRNAs (EZH2, KPNA2, LMNB1, LRRC1, MRGBP, SMARCD1, STMN1, SUB1, and UBE2A) were found to be determined as key miRNAs interacting with essential genes that interact with each other. A miRNA-mRNA regulatory network consisting of these key genes was constructed, and GO, KEGG enrichment analysis indicated that these key mRNAs might be associated with the suppression and progression of hepatocellular carcinoma. Importantly, immune infiltration analysis showed that the miRNA network was significantly associated with the infiltration abundance of multiple immune cells. These findings suggest that Gecko miRNAs may inhibit HCC progression and treat HCC by targeting critical miRNA-mRNA networks for cross-species regulation. It also provides a reference for future research and new drug development.
Prevalence of Food Insecurity and Associated Factors Among Households in Waliso Town, Oromia, Ethiopia
Authors: Tulem Tariku Gurara , Ayana Mulatu
Published: October 2022

Background: -Food insecurity is one of the underlying causes of malnutrition. And it`s a condition where people don`t have access to adequate amounts of safe and nutritious food and don`t consume the food that they have to grow normally and conduct an active and healthy life. Recently, urban food insecurity is a top agenda in Ethiopia, as households prone to food insecurity are rising because of various factors. However most of studies conducted on household food insecurity in Ethiopia before were in rural. hence we have aimed to assess the prevalence of food insecurity and associated factors among households in Waliso town, Oromia, EthiopiaMethods:Community-based cross-sectional study design was used from 17/12/2021 to 16/01/2022 among randomly selected 397 households in Waliso town. Data collection was done using a structured questionnaire and data were entered using Epi Info 7 and exported to SPSS version 20 software for analysis. To identify factors associated with household food insecurity, multivariable binary logistic regression analyses were done. An adjusted odds ratio along with a 95% confidence interval were estimated to measure the strength of the association. In this study, the level of statistical significance was declared at p<0.05.Results:The prevalence of household food insecurity was 63.4% 95% CI (58.6%, 68.2%). Factors associated with household food insecurity were family sizes 4-5[(AOR=2.26, 95% CI:- (1.13, 4.53)] and family sizes 6+[(AOR=4.12, 95% CI:-(1.62, 10.52)], having dependents 1-2 [(AOR= 3.95, 95% CI:-(1.78, 8.8)], >3 dependents [(AOR=5.59, 95% CI:-(2.01, 15.54)], Household head employment status; unemployed [(AOR=4.23, 95%CI:-(1.47, 12.2)], self-employed [(AOR=2.6, 95% CI:- (1.09, 6.18)], wage laborer[(AOR=7.95, 95% CI:- (2.68, 23.56)], Households live in Kebele house[(AOR=3.39. 95% CI:- (1.63, 7.08)], live in a private rental house[(AOR=3.69 95% CI:-(1.87,7.27)], Wealth index (poor) [(AOR=3.0, 95% CI:- (1.42, 5.89)].Conclusion:Majority of households were food insecure in Waliso town. Households had large family sizes, multiple dependents, Employment in Informal sectors, low wealth Index (poor), and not owning a house were significantly associated with household food insecurity. Hence, the Woliso town Administration should alleviate factors associated with household food insecurity by employing multi-sectorial collaboration.
Reliability of respiratory-gated real-time two-dimensional cine incorporating deep learning reconstruction for the assessment of ventricular function in an adult population
Authors: Orii Makoto , Sone Misato , Osaki Takeshi , Kikuchi Kei , Sugawara Tsuyoshi , Zhu Xucheng , Janich Martin A. , Nozaki Atsushi , Yoshioka Kunihiro
Published: October 2022

This study aimed to assess the image quality and accuracy of respiratory-gated real-time two-dimensional (2D) cine incorporating deep learning reconstruction (DLR) for the quantification of biventricular volumes and function compared with those of the standard reference, that is, breath-hold 2D balanced steady-state free precession (bSSFP) cine, in an adult population. Twenty-four patients (15 men, mean age 50.7 ± 16.5 years) underwent cardiac magnetic resonance for clinical indications, and 2D DLR and bSSFP cine were acquired on the short-axis view. The image quality scores were based on three main criteria: blood-to-myocardial contrast, endocardial edge delineation, and presence of motion artifacts throughout the cardiac cycle. Biventricular end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), ejection fraction (EF), and left ventricular mass (LVM) were analyzed. The 2D DLR cine had significantly shorter scan time than bSSFP (41.0 ± 11.3 s vs. 327.6 ± 65.8 s; p < 0.0001). Despite an analysis of endocardial edge definition and motion artifacts showed significant impairment using DLR cine compared with bSSFP (p < 0.01), the two sequences demonstrated no significant difference in terms of biventricular EDV, ESV, SV, and EF (p > 0.05). Moreover, the linear regression yielded good agreement between the two techniques (r ≥ 0.76). However, the LVM was underestimated for DLR cine (109.8 ± 34.6 g) compared with that for bSSFP (116.2 ± 40.2 g; p = 0.0291). Respiratory-gated 2D DLR cine is a reliable technique that could be used in the evaluation of biventricular volumes and function in an adult population.
Application of Time Series Analysis to Supplier Selection Problem: A Problem of Multi-Objective Decision Making
Authors: Gupta Srikant , Gupta Neha , Kamal Murshid
Published: October 2022

In today’s competitive environment, markets have made the purchasing function an ever more necessary action in supply chain management while in the same manner the survival of a business, for the most part, depends largely on its supplier’s. An effective and efficient supplier can give a competitive edge to a business. In general, the supplier selection is a multi-objective decision-making problem that involves several quantitative and qualitative factors that helps in minimizing the net ordering cost, minimizing the transportation cost, and minimizing the late deliveries. If we look at the different circumstances of life, we cannot predict anything in advanced. Therefore, we have taken the case of ambiguity in input parameters. Interval type-2 trapezoidal fuzzy numbers have been used to present the ambiguity in the input parameters, and crisp equivalent form has been obtained by taking the expected value. We also have used exponential smoothing forecasting analysis for getting the specific demand for the product to avoid the losses of shortages. Finally, we have used an efficient fuzzy goal programming approach for obtaining the compromise solution. A numerical example has been given to illustrate the concepts of the proposed methodology.
Characterization of the transcriptional responses of Armillaria gallica 012m to GA3
Authors: Cao Yapu , Cai Guolei , Tian Menghua , Mo Haiying , Chen Xin , Li Zhihao , Ji Qiaolin , He Kaixiang , Du Gang , Yang Haiying
Published: October 2022

Gastrodia elata needs to establish a symbiotic relationship with Armillaria strains in order to obtain nutrients and energy. However, the signaling crosstalk between G. elata and Armillaria strains is still unclear. During our experiment, we found that the vegetative mycelium of Armillaria gallica 012m grew significantly better in the media containing gibberellic acid (GA3) than the blank control group (BK). In order to explore the response mechanism, we performed an RNA-sequencing experiment to profile the transcriptome changes of A. gallica 012m cultured in the medium with exogenous GA3. The transcriptome-guided differential expression genes (DEGs) analysis of GA3 and BK showed that a total of 1309 genes were differentially expressed, including 361 upregulated genes and 948 downregulated genes. Some of those DEGs correlated with biological process, including positive regulation of chromosome segregation, mitotic metaphase/anaphase transition, attachment of mitotic spindle microtubules to kinetochore, mitotic cytokinesis, and nuclear division. These analyses explained that GA3 actively promoted the growth of A. gallica to some extent. Further analysis of protein domain features showed that deduced polypeptide contained 49 candidate genes of GA receptor, and 28 of them expressed in our samples. We speculate that GA receptors exist in A. gallica 012m. Comparative studies of proteins showed that the postulated GA receptor domains of A. gallica 012m have a higher homologous correlation with fungi than others based on cluster analysis.
Ester-Functionalised Ferrocene based Polyvinylbenzyl Chloride Nanofibre as a Decyanidating Agent
Authors: Adesoji A. O. , Shotonwa I. O. , Tshentu Z. R. , Adewuyi S.
Published: October 2022

Diazotization-esterification mechanism was employed to synthesize 1-(2-pyridylazo)-2-naphthyl-bis(ƞ5-cyclopentadienyl)ironcarboxylate, FePNCp, [Fe(C5H5)(C5H4CO2C15H10N3)] which was further embedded on synthesized electrospun polyvinylbenzylchloride (ePVBC) to form a functionalized nanofibre composite of poly(ferrocenyl-l-(2-pyridylazo)-2-naphthylvinylbenzylchloride, (FePNCp-PVBC). FePNCp and ePVBC were characterized using spectroscopic (1H NMR, FT-IR, GC/MS, UV-vis) and scanning electronic microscopic techniques. The polymeric solution of PVBC was pumped via a spinneret at a flow rate of 1.2 mL/h with an applied 30 kV for nanofibres collection. The morphology of the functionalized nanofibre showed smooth fibrous and porous assembled structure with average particle size of 19.92 nm. Owing to the intrinsic properties of the newly produced material, it was applied in the entrapping of cyanide ions from an aqueous medium. Using a sorbent dosage of 0.01g in 8 mg/L CN− concentration, 92.2% decyanidation capacity was observed within 45 minutes for FePNCp-PVBC while 65.83% was obtained for the unfunctionalized ePVBC. The obvious improvement recorded by FePNCp-PVBC for the entrapment of CN− ions could be attributed to coordinative interaction between ferrocenyl molecule and cyanide ligand. By comparing with similar nanofibre materials, this new FePNCp-PVBC gave higher performance efficiency, thus could serve as a better alternative to cyanide detoxification.
Low-frequency variability enhancement of the midlatitude climate in an eddy-resolving, coupled ocean-atmosphere model. Part II: Mechanisms
Authors: Kurashina Ryosuke , Berloff Pavel
Published: October 2022

This paper investigates the spatial inhomogeneity of the time-averaged, quasigeostrophic, double-gyre circulation response to fixed, realistic, large-scale modes of wind-stress forcing. While the companion paper of this study focused on understanding the anatomy of the low-frequency midlatitude climate variability in the coupled configuration of the same model, this paper looked at understanding the nature of the wind-induced ocean gyre response in an ocean-only configuration of the same model. Our analysis revealed two time-averaged responses to an east-west dipole wind-stress curl anomaly in the ocean basin. Firstly, wind-stress anomalies in the western ocean basin led to changes in relative strength of the inertial recirculation zones and jet-axis tilt which is consistent with an advection-dominated, nonlinear adjustment of the ocean gyres to anomalous forcing. Secondly, wind-stress curl anomalies in the eastern ocean basin was found to induce a largely independent response involving meridional shifts of the eastward jet extension. The effects of time-averaged advection in this region were weak and the discovery of westward-propagating Rossby waves along the eastward jet revealed the response is more akin to a baroclinic Rossby wave adjustment.
Long-term outcomes of nasopharyngeal carcinoma by Epstein-Barr virus status in the Chinese population: a multicenter investigation
Authors: Xiong Yudi , Yuan Mengting , Liu Zhigang , Huang Jing , Bi Jianping , Pi Guoliang , Li Ying , Li Yanping , He Hanping , Verma Vivek , Tian Suqing , Han Guang
Published: October 2022

Background
Because the vast majority of nasopharyngeal carcinoma (NPC) in Chinese patients is a direct result of Epstein–Barr virus (EBV) infection, there is a dearth of data for EBV-negative patients in this population. This multicenter study sought to examine the clinical characteristics of this population and compare long-term outcomes with a propensity-matched (1:1.5) EBV-positive cohort.
Methods
NPC patients with known EBV status from four hospitals were collated (2013–2021). A logistic regression model was conducted to evaluate the relationship between patient characteristics and EBV status. The Kaplan–Meier method and Cox regression analysis were used to analyze survival data.
Results
This study analyzed 48 (40%) EBV-negative and 72(60%)EBV-positive patients. The median follow-up time was 63.5 months. Most EBV-negative NPC patients (77.1%) were diagnosed in the advanced stages, and no significant prognostic factors were discerned in this subpopulation. EBV-negative disease was more associated with the keratinizing subtype (18.8% vs. 1.4%, P < 0.05), whereas nearly all EBV-positive cases were non-keratinizing. Compared to EBV-negative NPC patients, EBV-positive NPC patients were more likely to develop local recurrence (9.7% vs. 0%, P = 0.026). There was no statistical difference in mortality (8.3% vs. 4.2%, P = 0.34) during the follow-up period.
Conclusions
These multicenter data suggest that in the Chinese population, EBV-negative disease have similar survival outcomes as EBV-positive cases, despite the increased local recurrence in the latter. Further work is required to corroborate these conclusions.
Trial registration:
retrospectively registered (Permit Number: LLHBCH2022YN-037). This retrospective study followed the principles of the Helsinki Declaration and was approved by the Ethics Committee of Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei, China.
A rapid plant regeneration system by using stem and leaf explants of Olea europea L. cv. Koroneiki; a multipurpose bioenergy tree
Authors: Khalid Laraib , Jamil Iqra , Sajid Zahoor Ahmad , Aftab Faheem
Published: October 2022

Olea europea L. cv. koroneiki is a multipurpose tree which belongs to family Oleaceae. Koroneiki is famous for its virgin oil production and suitable for high density growing system around the world. Being grafted and recalcitrant in nature, Koroneiki demands an efficient in vitro protocol for its propagation and conservation. The aim of the present study was to set up an efficient protocol for in vitro regeneration of this beneficial olive cultivar. Three different basal media, Murashige and Skoog (MS), Olive Medium (OM) and Woody Plant Medium (WPM) were tested for two types of explants, leaf and nodal segments for callus induction and shoot regeneration. To find out the best explant disinfestation method during this study, explants were soaked in detergent for 15 minutes with continuous agitation. After washing, explants were rinsed with 70% ethanol for 10 seconds and finally treated with 0.1% mercuric chloride for 3 minutes and rinsed 4–5 times with autoclaved distilled water under the laminar air flow cabinet considered as most suitable for cv. Koroneiki. Media were either used alone or supplemented with 6-benzylaminopurine (BAP) (8.8 and 17.7 µM) and zeatin (4.56 and 9.12 µM) to find out suitable PGR for callus induction and shoot proliferation. Maximum callus induction (70%) on nodal explants was observed on OM medium containing 9.12 µM zeatin + 17.7 µM BAP under both dark and light conditions. The WPM containing the combination of BAP and zeatin showed 67% callus induction under light by using nodal explants. However, in case of leaf explants, 50% callus induction response was observed under dark conditions, but no callus was observed under light. The OM supplemented with combination of BAP (17.7 µM) and zeatin (9.12 µM) induced highest shoot length (1.5) and maximum number of leaves (3.5). This study might helpful for commercial propagation of cv. Koroneiki at mass scale under in vitro conditions to fulfill the virgin oil demand for rapidly growing population.
Online interventions and virtual day centres for young people who use drugs – potential for harm reduction?
Authors: Sande Matej , Dekleva Bojan , Razpotnik Špela , Tadič Darja , Rozman Mija Marija Klemenčič , Pavel Jana Rapuš
Published: October 2022

Background
The methodological part of the large-scale study on the psychosocial distress of young people in Slovenia focused on vulnerable young people who use drugs and explored the potential of online interventions in harm reduction programmes. We looked at the needs of young people who, at the time of the research, were attending a virtual Discord day centre hosted by the DrogArt NGO or were involved in the organisation's other programmes. We explored young people's knowledge of online interventions, their satisfaction with them, and the opportunities they offer for harm reduction programmes.
Methods
The study used a qualitative methodology with a combination of deductive and inductive coding, and relied on framework analysis. 18 young people who had used drugs or had stopped using participated in the study. The inclusion criterion was a minimum age of 25 years. In-depth interviews were conducted with the young people, which lasted on average between one and a half and two hours.
Results
The study showed the potential of online interventions, specifically the virtual day centre, which provide a safe and relaxed space for young people in the sample to meet and talk, which is accessible and where they feel welcome. Online interventions have also enabled some of the sample to engage in the "offline" support types offered within the organisation. The main advantages of online interventions are seen by young people as being more "geographically" accessible and more available during the COVID-19 epidemic. Online support suits some people because they can leave sessions more quickly and it is more informal, while others prefer it because of specific problems or difficulties, such as social anxiety.
Conclusions
The results show the relatively high potential of online interventions in harm reduction programmes, as well as more broadly for young people with various psychosocial difficulties and who, for example, do not use drugs. These types of support allow quick contact with a professional or peer and facilitate contact with a support programme. Young people are still poorly informed about the support programmes available in Slovenia and would like more information. Thus, in addition to developing and upgrading the network of programmes, we need to focus on providing information to young people through channels that are close to them and can reach them.
A pan-cancer analysis of the oncogenic role of ribonucleotide reductase subunit M2 in human tumors
Authors: Wang Yong , Chen Rong , Zhang Jing , Zeng Peng
Published: October 2022

Although there is evidence that ribonucleotide reductase subunit M2 (RRM2) is associated with many cancers, no pan-cancer analysis is available. This study aims to explore the potential oncogenic role of RRM2 in pan-cancer based on the datasets of TCGA (The cancer genome atlas). RRM2 was highly expressed in most cancers and obvious correlation existed between RRM2 expression and prognosis of tumor patients. RRM2 expression was associated with infiltration level of diverse immune cell as well as endothelial cells, immune checkpoint, tumor mutational burden (TMB) and microsatellite instability (MSI). Moreover, the cell cycle pathway was involved in the functional mechanisms of RRM2. Our pan-cancer study provides a fairly comprehensive understanding of the oncogenic roles of RRM2 across different tumors.
Meiotic abnormalities in sugarcane (Saccharum spp.): Evidence for peri- and paracentric inversions
Authors: Oliveira Gleicy Kelly , Soares Nina Reis , Costa Zirlane Portugal , Almeida Carmelice Boff , Machado Raquel Moura , Mesquita Amanda Teixeira , Carneiro Monalisa Sampaio , Forni-Martins Eliana R. , Mondim Mateus , Vieira Maria Lucia Carneiro
Published: October 2022

The modern cultivars of sugarcane (Saccharum spp.) are highly polyploid and accumulate aneuploidies due to their history of domestication, genetic improvement and interspecific hybrid origin involving the domesticated sweet species S. officinarum ('noble cane') and the wild S. spontaneum, both with an evolutionary history of polyploidy. The first hybrids were backcrossed with S. officinarum, and selection from progenies in subsequent generations established the genetic basis of modern cultivars. Saccharum genome complexity has inspired several molecular studies that have elucidated aspects of sugarcane genome constitution, architecture and cytogenetics. Herein, we conducted a comparative analysis of the meiotic behavior of representatives of the parentals S. officinarum and S. spontaneum, and the commercial variety, SP80-3280. S. officinarum, an octoploid species, exhibited regular meiotic behavior. In contrast, S. spontaneum and SP80-3280 exhibited several abnormalities from metaphase I to the end of division. We reported and typified, for the first time, the occurrence of peri- and paracentric inversions. Using in-situ hybridization techniques, we were able to determine how pairing association occurred at diakinesis and, in particular, the chromosome composition of SP80-3280. Our findings have implications for sugarcane genetic mapping, genomics, and for studies on resynthesized polyploids.
Impact of Deccan Volcanism on Reorganization of the Indian plate kinematics
Authors: Bhagat Amarjeet Ramesh , Sangode S. J. , Dongre Ashish
Published: October 2022

Western Indian Ocean basin shows one of the most complex signatures of the ocean floor anomalies by juxtaposition of the rapidly evolving, multiple spreading ridges, subduction systems and microcontinental slivers. This study based on ocean floor magnetic anomalies, gravity gradient map, tomographic profiles and geometrical kinematic models reports a significant westward drift of the Central Indian Ridge (CIR) segments. Documented precisely between the latitudes 17°S and 21°S the drift is coincident with the Deccan volcanism at ~ 65 ± 2 Ma and we further explain its bearing on the Indian plate kinematics. The progressive stair-step trend of the ridge segments towards NE is marked by anomalous deflection to NW for a brief distance of ~ 217 km between these latitudes represented by the anomalies C30n-C29n. The observed length of the ridge segments moving NW at 17°S match the calculated NW drift rates of Indian plate (Bhagat et al., 2022). We infer that the NW drift and its restoration towards NE triggered short Plume Induced Subduction Initiation along the Amirante trench. Further a plume induced lithospheric tilt of the Indian plate (Sangode et al 2022) led to restoration of subduction along the Sunda trench at ~ 65 Ma imparting new slab pull force over the Indian subcontinent besides the NE trend for CIR. This episode resulted into anticlockwise rotation of the Indian plate along with accelerated drift rates due to vector addition of the plume push and the slab pull forces from Eurasian as well as Sunda subduction systems after 65 Ma. The Deccan eruption thus resulted in major geodynamic reorganization that altered the kinematics of Indian plate; and the signatures of which are well preserved over the ocean floor.
In silico bioprospecting of receptors for Doderlin: an antimicrobial peptide isolated from Lactobacillus acidophilus
Authors: Seif Elias Jorge Muniz , Icimoto Marcelo Yudi , Junior Pedro Ismael da Silva
Published: October 2022

Background
The emergence of resistant bacterial strains against traditional antibiotics and treatments increases each year. Doderlin is a cationic and amphiphilic peptide active against gram-positive, gram-negative and yeast stains. The aim of the present work was to identify potential receptors associated with the antimicrobial activity of Doderlin using in silico bioinformatics tools.
Methods
To search for potential targets of Doderlin, PharmMapper software was used. Molecular docking between Doderlin and the receptor was performed by PatchDock. Additional interaction and ligand site prediction for each receptor was performed by I-TASSER software.
Results
Those PDB, 1XDJ (11746), 1JMH (11046), 1YR3 (10578), and 1NG3 (10082), showed the highest dock score. Doderlin was found to be predicted/co-localized with A and B, enzymes accountable for nitrogenic bases.
Conclusion
The resulting receptor bioprospecting is highly correlated and suggests that Doderlin might act by interfering with DNA metabolism/production of bacteria, altering microorganism homeostasis and growth impairment.
Association between PTPN1 polymorphisms and obesity-related phenotypes in European adolescents: influence of physical activity
Authors: Salazar-Tortosa Diego F. , Labayen Idoia , González-Gross Marcela , Seral-Cortes Miguel , Moreno Luis A. , Zapico Augusto G. , Widhalm Kurt , Meirhaeghe Aline , Enard David , Ruiz Jonatan R
Published: October 2022

Background To study the associations ofProtein Tyrosine Phosphatase-N1(PTPN1) polymorphisms with obesity-related phenotypes in European adolescents, and the influence of physical activity on these relationships. Methods Five polymorphisms ofPTPN1were genotyped in 1,057 European adolescents (12–18 years old). We measured several phenotypes related to obesity, such as adiposity markers, and biochemical and clinical parameters. Physical activity was objectively measured by accelerometry. Results The T, A, T, T and G alleles of the rs6067472, rs10485614, rs2143511, rs6020608 and rs968701 polymorphisms, respectively, were associated with lower levels of obesity-related phenotypes (i.e., body mass index, body fat percentage, hip circumference, fat mass index, systolic blood pressure and leptin) in European adolescents. In addition, the TATTG haplotype was associated with lower body fat percentage and fat mass index compared to the AACCA haplotype. Finally, when physical activity levels were considered, alleles of the rs6067472, rs2143511, rs6020608 and rs968701 polymorphisms were only associated with lower adiposity in active adolescents. ConclusionsPTPN1polymorphisms were associated with adiposity in European adolescents. Specifically, alleles of these polymorphisms were associated with lower adiposity only in physically active adolescents. Therefore, meeting the recommendations of daily physical activity may reduce obesity risk by modulating the genetic predisposition to obesity.
A representação da Agroecologia - uma análise no site da EMATER-MG
Authors: MARIANO Glenio Martins de Lima , PEREIRA Adalgisa Jesus , Reis Janderson Damaceno dos
Published: October 2022

Este artigo, tem por objetivo, analisar as representações sociais construídas pelo site da Empresa de Assistência Técnica e Extensão Rural de Minas Gerais, Emater–MG sobre ações de Agroecologia realizadas no Estado. Assim, sopesará os signos que são relacionados à Agroecologia e ao que eles representam na extensão rural. Foram analisadas 5 edições do Relatório Social de atividades publicados no período de 2015 a 2019. Foram analisados os conteúdos das agendas anuais em Agroecologia, os quantitativos de atendimentos e prospecção temporal evolucionária. Analisou-se imagens e suas referências de significados e identificadas categorias de análises. O estudo demonstrou que a Agroecologia disseminada pela Emater–MG é transmitida para o público como sinônimo de modernidade, tecnologia, de modo a consolidar a representação positiva da agroecologia, no entanto sua expressividade diminuiu, visto que o tema deixou de fazer parte das agendas estratégicas da empresa.
Propiedades psicométricas de la Escala de Doble Estándar Sexual (DSS) en universitarios chilenos: sexo, actitudes de género y religiosidad
Authors: Díaz-Gutiérrez Camila , Pérez Beatriz , Concha-Salgado Andrés
Published: October 2022

Ante la ausencia de instrumentos en Chile para medir el fenómeno del Doble Estándar Sexual (SDS), el presente estudio tuvo como objetivo evaluar las propiedades psicométricas de la Escala de Doble Estándar Sexual (DSS). La muestra se compuso de 1.036 personas universitarias del centro y sur de Chile. El 61,1% (n = 633) fueron mujeres, la edad promedio fue de 20,4 años y un 31,7% (n = 259) se identificó como ateo o agnóstico. Mediante análisis factorial confirmatorio, la DSS obtuvo una estructura unidimensional en la muestra de estudio, un α Ordinal = 0,918, y evidencias de validez convergente y discriminante: a mayor puntuación en SDS, mayores actitudes estereotipadas sobre el género y menores actitudes trascendentes. Los participantes religiosos obtuvieron puntuaciones medias más altas en la DSS y los hombres obtuvieron puntajes de SDS significativamente mayores que los de las mujeres. Además, tanto en el caso de los hombres como en el de las mujeres, el grupo de participantes con actitudes estereotipadas extremas obtuvo puntuaciones significativamente más elevadas en DSS que el grupo participante con actitudes trascendentes extremas. Con base en la evidencia que asocia el SDS con el funcionamiento y satisfacción sexual, prácticas sexuales de riesgo, la agresión y victimización sexual, y la violencia en relaciones de pareja, la DSS se distingue como un aporte para el desarrollo de programas educativos sexoafectivos y la identificación de individuos y grupos de riesgo.
An Inconsistency Responding Scale for the Durand Adaptive Psychopathic Traits Questionnaire
Authors: Durand Guillaume
Published: October 2022

Careless and inconsistent responding is a common issue with self-reported instruments, observed in approximately 10% of respondents. The purpose of this study was to develop an Inconsistency Responding Scale (IRS) for the Durand Adaptive Psychopathic Traits Questionnaire (DAPTQ). First, a derivation sample (N = 525) was used to develop the IRS-DAPTQ, a scale generating a total score from the absolute difference of 12 pairs of items with high intra-correlation. Second, the validity of the IRS-DAPTQ was assessed using human (N = 943) and randomly generated (N = 1,000) data. The IRS-DAPTQ successfully differentiated human data from randomly generated data. The IRS-DAPTQ scores showed a negative association with conscientiousness and had higher specificity for a sample of the general population recruited online than for a sample of undergraduate students. These findings support the usefulness of the IRS-DAPTQ for identifying individuals displaying an inconsistent responding style.
The Influence of Different Types of Social Support in Caregivers of People with Dementia
Authors: Antelo Paula , Espinosa Pablo
Published: October 2022

Being a caregiver for a person with dementia has negative health consequences, like depression, stress, anxiety, and burden. Consequently, it is important that caregivers receive social support and social resources during the trajectory of the disease. This study analyzes how different types of social resources impact caregivers’ well-being. A cross-sectional sample of 260 caregivers was divided into groups, depending on the social resources they had access to. Namely, social media (N = 157), day-care centers (N = 40) or residential centers (N = 63).  Social support, isolation, burden, coping strategies, and satisfaction measures were administered to participants, and groups were compared using ANOVA and SEM models. Help-seeking and social support received through social resources predicted satisfaction and caregivers’ burden. Formal resources positively influence care providers and their absence diminishes the impact of social support on perceived burden. This research reflects the importance of formal resources in the lives of caregivers and the benefits they generate throughout the course of the pathology. Supporting caregivers and bringing the social resources closer to them indirectly improves the informal response offered to people with dementia.
Assessing Language Skills Using Diagnostic Classification Models: An Example Using a Language Instrument
Authors: Sideridis Georgios D. , Tsaousis Ioannis , Al-Harbi Khaleel
Published: October 2022

The primary purpose of the present study was to inform and illustrate, using examples, the use of Diagnostic Classification Models (DCMs) for the assessment of skills and competencies in cognition and academic achievement. A secondary purpose was to compare and contrast traditional and contemporary psychometrics for the measurement of skills and competencies. DCMs are described along the lines of other psychometric models within the Confirmatory Factor Analysis tradition, such as the bifactor model and the known mixture models that are utilized to classify individuals into subgroups. The inclusion of interaction terms and constraints along with its confirmatory nature enables DCMs to accurately assess the possession of skills and competencies. The above is illustrated using an empirical dataset from Saudi Arabia (n = 2,642), in which language skills are evaluated on how they conform to known levels of competency, based on the CEFR (Council of Europe, 2001) using the English Proficiency Test (EPT).
‘You Treated Me Like an Object, I Don’t Forgive You!’: The Effect of Dehumanization on Interpersonal Forgiveness from the Victim’s Perspective
Authors: Pica Gennaro , Fino Emanuele
Published: October 2022

Introduction. There is a gap in the literature on the impact of the perceptions of a victim of an offense upon their forgiveness towards the offender, particularly when those perceptions include dehumanization. Objectives. The present cross-sectional exploratory study aimed at examining whether the perceptions of being treated in a dehumanized fashion influences interpersonal forgiveness, avoidance, and revenge intentions of dehumanized victims towards the offender. Method. We recruited 149 individuals from the general population, who took part in an online task, consisting of remembering an offense they had been victim of and of a set of self-reported measures of dehumanization (uniqueness and nature), interpersonal forgiveness, avoidance, and revenge intentions. We used multiple linear regression to test the study’s hypotheses. Results. The perceived denial of the victims’ human uniqueness was not associated with the dependent variables, whereas the perceived denial of the victims’ human nature was significantly and negatively associated with interpersonal forgiveness and positively with avoidance and revenge intentions, after controlling for the effects of a set of known covariates. Conclusions. The results revealed a role for dehumanization (nature) in predicting the victims’ interpersonal forgiveness, avoidance, and revenge intentions. Implications for further research are discussed.
Optimal operation of a single unit in a pumping station based on a combination of orthogonal experiment and 0-1 integer programming algorithm
Authors: Wang Shiwen , Cheng Jilin , Zhu Bowen
Published: October 2022

The frequent start–stop scheme in the operation management of large pumping stations causes several problems, e.g., energy consumption and a potential safety hazard. We therefore established a mathematical model for the optimal operation of a large-scale pumping station considering the start-stop loss of machine. The objectives of the optimization model included electricity charges for a pumping station operation and the start-stop loss of a pumping station. The blade angle and start-stop scheme were taken into account as the double-decision variables, while the target water extraction (equality constraint), start-stop scheme, and power were the constraint conditions. A combination of an orthogonal experiment and a 0-1 integer programming algorithm was proposed to explore the optimal solution of the model. A real case of a single-unit pump station in China was applied to prove the effectiveness of the algorithm. The results showed that the optimization efficiency of the proposed algorithm was 4%–10% higher than that of the genetic algorithm. Additionally, the maximum optimization benefit was obtained when there were fewer than three start-stops during the operation process. The proposed algorithm provided a reference for similar complex nonlinear models.
Sushchnost' i poniatie effektivnosti deiatel'nosti organizatsii
Authors: Menovshchikova Alena Nikolaevna
Published: October 2022

The scientific article presents the results of the analysis of the definition of the theoretical characteristics, essence and concept of the economic category «the effectiveness of the organization's activities». Particular attention is paid to the concept of «economic efficiency» in assessing the activities of the enterprise. The relevance of determining the essence and concept of efficiency in the activities of the organization is that, thanks to the assessment of its indicators, the success of doing business is analyzed. It has been determined that the essence and characteristics of «the effectiveness of the organization» is defined as the degree of efficiency and effectiveness of the commercial activities of the enterprise.
The Effect of Phytohormonal Steroids in Combination with Succinic Acid on the Resistance of Hordeum Vulgare L. to Helminthosporium teres Sacc.
Authors: Manzhаlesаva Neli , Litvinovskaya Raisa P. , Poljanskaja Svetlana N. , Khripach Vladimir A.
Published: October 2022

Aim:

The aim of this investigation is study the BS effect on the growth of Helminthosporium teres Sacc. and to elucidate the protective effect of brassinosteroids and their tetrahemisuccinates on spring barley (Hordeum Vulgare L.) exposed to biotic stress caused by this phytopathogenic fungus.

Background:

Brassinosteroids and their tetrahemisuccinates are considered as protectors of the fungal infection caused by H.teres.

Objective:

Evaluation of the effect of brassinosteroids, their mixtures and conjugates with succinic acid against the pathogen H.teres, as well as in spring barley crops against a natural infectious background.

Methods:

The fungistatic activity of brassinosteroids and their tetrahemisuccinates was evaluated in relation to the phytopathogenic fungus H.teres. The effect of BS and their derivatives on the processes of adaptation of spring barley plants to the pathogen of net spotting of the phytopathogenic fungus H.teres was studied on a model pathosystem and in the agrocenosis.

Results:

A fungistatic activity of the synthesized substances was revealed, which consists in inhibiting the growth of the phytopathogenic fungus H.teres on a solid nutrient medium by 35-40%. Succinic acid can enhance the fungistatic effect of brassinosteroids, which is more noticeable when using conjugates with succinic acid than in mechanical mixtures. In field experiments, it was shown that the studied compounds and their mixtures applied as a single spraying in the beginning of tubing phase reduced the development of leaf spots caused by phytopathogenic fungi.

Conclusion:

The results obtained indicate that brassinosteroids with succinic acid both in the form of conjugates and mechanical mixtures show fungistatic activity.