bluuebunny/crossref_metadata_2025 huggingface dataset:
Late Cenozoic Evolution and Present Tectonic Setting of the Aegean–Hellenic Arc
Authors: Mantovani Enzo , Babbucci Daniele , Tamburelli Caterina , Viti Marcello
Published: February 2022

The Aegean–Hellenic arc is a deformed sector of a long heterogeneous orogenic system (Tethyan belt), constituted by an inner old metamorphic crystalline core flanked by younger chains of European and African affinity, running from the Anatolian to the Pelagonian zones. Due to the convergence between the Arabian promontory and the Eurasian continental domain, the Anatolian sector of that belt has undergone a westward extrusion, accommodated by oroclinal bending, at the expense of the surrounding low buoyancy domains. Since the late Miocene, when the Aegean Tethyan belt collided with the Adriatic continental promontory, the southward bowing of the Aegean–Hellenic sector accelerated, leading to the consumption of the Levantine and Ionian oceanic domains and to the formation of the Mediterranean Ridge accretionary complex. The peculiar distribution of extensional and compressional deformation in the Aegean zone has mainly been influenced by the different rheological behaviours of the mainly ductile inner core (Cyclades arc) and of the mainly brittle outer belt (Hellenic arc). The bowing of the inner belt developed without involving any major fragmentation, whereas the outer brittle belt underwent a major break in its most curved sector, which led to the separation of the eastern (Crete–Rhodes) and western (Peloponnesus) Hellenic sectors. After separation, these structures underwent different shortening patterns, respectively driven by the convergence between southwestern Anatolia and the Libyan continental promontory (Crete–Rhodes) and by the convergence between the Cycladic Arc and the Adriatic continental domain (Peloponnesus). A discussion is given about the compatibility of the observed deformation pattern with the main alternative geodynamic interpretations and with the Nubia–Eurasia relative motions so far proposed.
COVID-19 Vaccination-Related Sentiments Analysis: A Case Study Using Worldwide Twitter Dataset
Authors: Reshi Aijaz Ahmad , Rustam Furqan , Aljedaani Wajdi , Shafi Shabana , Alhossan Abdulaziz , Alrabiah Ziyad , Ahmad Ajaz , Alsuwailem Hessa , Almangour Thamer A. , Alshammari Musaad A. , Lee Ernesto , Ashraf Imran
Published: February 2022

COVID-19 pandemic has caused a global health crisis, resulting in endless efforts to reduce infections, fatalities, and therapies to mitigate its after-effects. Currently, large and fast-paced vaccination campaigns are in the process to reduce COVID-19 infection and fatality risks. Despite recommendations from governments and medical experts, people show conceptions and perceptions regarding vaccination risks and share their views on social media platforms. Such opinions can be analyzed to determine social trends and devise policies to increase vaccination acceptance. In this regard, this study proposes a methodology for analyzing the global perceptions and perspectives towards COVID-19 vaccination using a worldwide Twitter dataset. The study relies on two techniques to analyze the sentiments: natural language processing and machine learning. To evaluate the performance of the different lexicon-based methods, different machine and deep learning models are studied. In addition, for sentiment classification, the proposed ensemble model named long short-term memory-gated recurrent neural network (LSTM-GRNN) is a combination of LSTM, gated recurrent unit, and recurrent neural networks. Results suggest that the TextBlob shows better results as compared to VADER and AFINN. The proposed LSTM-GRNN shows superior performance with a 95% accuracy and outperforms both machine and deep learning models. Performance analysis with state-of-the-art models proves the significance of the LSTM-GRNN for sentiment analysis.
Treatment Resistance Risk in Patients with Newly Diagnosed Multiple Myeloma Is Associated with Blood Hypercoagulability: The ROADMAP-MM Study
Authors: Gerotziafas Grigorios T. , Fotiou Despina , Sergentanis Theodoros N. , Papageorgiou Loula , Fareed Jawed , Falanga Anna , Sabbah Michèle , Garderet Laurent , Terpos Evangelos , Elalamy Ismail , Van Dreden Patrick , Dimopoulos Meletios A.
Published: February 2022

Biomarkers of hypercoagulability are potential candidates for the evaluation of risk for primary treatment resistance in patients with newly diagnosed multiple myeloma (NDMM). This study aimed to identify the most clinically relevant biomarkers for the evaluation of treatment-resistance risk. NDMM patients (n = 144) were enrolled prior to treatment initiation. Response to treatment was assessed at 3 months. STA-Procoag-PPL®, factor VIIa factor V, antithrombin, fibrin monomers, soluble thrombomodulin (TM), free TFPI, D-Dimer, P-selectin, heparanase, and thrombin generation (Calibrated Automated Thrombogram® and PPP-Reagent®) were measured. In total, 23% (n = 33) of the patients showed a poor response/resistance to treatment (defined as stable disease, minor response, progressive disease). Poor response/treatment resistance was associated with longer Procoag-PPL® clotting time, higher Peak of thrombin, and higher D-Dimer levels. These biomarkers were included in a prognostic model derived via multivariate analysis. The model had 84% sensitivity and 59% specificity to identify patients at high risk of treatment resistance. The AUC of the ROC analysis for the model was 0.75. In conclusion, Procoag-PPL®, D-Dimer, and Peak of thrombin generation are clinically relevant for the identification of NDMM patients at risk for poor response to antimyeloma treatment. A prospective multicenter study is necessary for the validation of this new approach.
Tolerance Screening for Phytophthora capsici and Fusarium solani f. sp. cucurbitae in Cucurbita spp. and Gene Expression Responses in Mutant Families
Authors: Ayala-Doñas Alejandro , Gómez Pedro , de Cara-García Miguel
Published: February 2022

Cucurbita species can be affected by soil-borne pathogens, such as Phytopthora capsici and Fusarium solani f. sp. cucurbitae (Fsc). Diverse commercial and conserved lines of Cucurbita spp. were tested. C. pepo subsp. pepo genotypes showed the highest susceptibility to both pathogens. The tolerance to P. capsici and Fsc was then screened in a zucchini mutant population. Two M3 mutant lines (Cp107 and Cp116) with a high occurrence of tolerant individuals to Phytophthora capsici were obtained from a screening of 160 M2 mutant lines. The M3 lines presented higher tolerance than the background MUCU-16. Furthermore, in the inoculated samples, both mutants overexpressed CpDEF and expressed more CpPAL and CpChiIV than the susceptible control. It has been previously shown that this expression pattern could be associated with tolerance in the P. capsici - Cucurbita spp. pathosystem. The M3 lines obtained could be applied in breeding programs, as they are likely to be compatible with the highly susceptible C. pepo subsp. pepo genotype.
Web Architecture Affects the Functional Response of the Space Web-Builder Kochiura aulica against Trioza erytreae in the Laboratory
Authors: Félix-Oliveira Diogo , Pereira José Alberto , Benhadi-Marín Jacinto
Published: February 2022

The “citrus greening disease” or huanglongbing (HLB) is caused by the Gram-negative bacteria Candidatus Liberibacter spp. One vector of HLB, the African citrus psyllid Trioza erytreae (del Guercio, 1918), was recorded for the first time in 2014, in mainland Spain, and since then, it has spread throughout the Iberian Peninsula. Spiders could be natural enemies of T. erytreae. In this work, we assessed the potential of a model spider species, selected according to the most abundant guild in the field, as a natural enemy of T. erytreae. Theridiidae was the most successful family, capturing adults of T. erytreae in the field. Kochiura aulica (Theridiidae) was selected as a model for functional response assays in the laboratory. The effect of web-building plasticity on the functional response of K. aulica was investigated using two types of arena. The spiders developed tubular-like or branch-like webs according to the spatial constraints. The web architecture significantly shifted the trapping efficiency of K. aulica. Functional responses for tubular and branch webs were both Type-II, but more psyllid prey were captured and killed in the tubular webs than in branch webs. In addition, significantly more psyllids survived in branch-like webs. Our results suggest that web architecture is a key factor driving the number of captured adults of the psyllid. Space web builders could be successful natural enemies of T. erytreae, although further research is needed to clarify the influence of web-building plasticity on the functional response and trapping efficiency of spiders.
Nutrient Uptake and Yield of Chinese Cabbage (Brassica rapa L. Chinensis) Increased with Application of Macadamia Husk Compost
Authors: Maselesele Dembe , Ogola John B. O. , Murovhi Romeo N.
Published: February 2022

There is a dearth of information on the effect of macadamia husk compost (MHC) on the productivity of short-season, shallow-rooted annual crops. We assessed the response of yield and nutrient uptake of Chinese cabbage (Brassica rapa L. Chinensis) to MHC application. The treatments (zero control, inorganic fertilizer (100:60:60 kg NPK ha−1), and 15 and 30 t ha−1 MHC) were arranged in a randomized complete block design and replicated three times. Number of leaves, leaf area index, leaf biomass, and leaf nutrient concentration (N, P, K, Ca, Mg, Zn, Cu, Mn, and B) were determined at 28, 46, and 74 days after transplanting (DAT), and root length and root biomass were determined at 74 DAT. Inorganic fertilizer and MHC increased root biomass and root length with greater increases recorded at the higher MHC rates. Number of leaves, leaf area index, leaf biomass, and nutrient concentration were greater with application of inorganic fertilizer (28 DAT) and 30 t ha−1 (74 DAT) suggesting that the effect of organic soil amendments is more pronounced over the long run compared with inorganic fertilizers. The concentration of macronutrients in the leaf increased with application of MHC and inorganic fertilizer. Clearly, MHC may be beneficial in improving the leaf yield and nutrient uptake of Chinese cabbage in a loamy sand soil, but the effect varies with time of harvesting.
Arsenic Accumulation and Physiological Response of Three Leafy Vegetable Varieties to As Stress
Authors: Meng Yuan , Zhang Liang , Yao Zhi-Long , Ren Yi-Bin , Wang Lin-Quan , Ou Xiao-Bin
Published: February 2022

Arsenic (As) in leafy vegetables may harm humans. Herein, we assessed As accumulation in leafy vegetables and the associated physiological resistance mechanisms using soil pot and hydroponic experiments. Garland chrysanthemum (Chrysanthemum coronarium L.), spinach (Spinacia oleracea L.), and lettuce (Lactuca sativa L.) were tested, and the soil As safety threshold values of the tested leafy vegetables were 91.7, 76.2, and 80.7 mg kg−1, respectively, i.e., higher than the soil environmental quality standard of China. According to growth indicators and oxidative stress markers (malondialdehyde, the ratio of reduced glutathione to oxidized glutathione, and soluble protein), the order of As tolerance was: GC > SP > LE. The high tolerance of GC was due to the low transport factor of As from the roots to the shoots; the high activity of superoxide dismutase, glutathione peroxidase, and catalase; and the high content of phytochelatin in the roots. Results of this work shed light on the use of As-contaminated soils and plant tolerance of As stress.
Impact of Resource on Green Growth and Threshold Effect of International Trade Levels: Evidence from China
Authors: Liu Haiying , Guo Wenqi , Wang Yu , Wang Dianwu
Published: February 2022

International trade levels can change the relationship between resource endowments and green economic growth. Therefore, this study tested the resource curse hypothesis from the perspective of green growth in China using provincial-level panel data for 2005–2017. Energy conservation and environmental improvement were considered under green growth to further analyze the regional mechanism of the resource curse. A panel threshold model was used to identify the impact of import and export threshold effects on the transformation of this mechanism. The resource curse hypothesis was found to be valid nationwide; it hindered green economic growth mainly by impeding energy conservation and curbing environmental improvement. In terms of regional differences in green growth, resource endowment had a positive impact on the eastern region, a negative impact on the central region, and no effect on the western region. When the levels of import and export trade exceeded the threshold values, the resource curse effect was enhanced by reducing energy conservation and weakened by promoting environmental improvement, respectively. Therefore, the Chinese government should establish a more reasonable import and export trade structure, promote changes to the energy structure and green technological innovation, and reduce the negative impact of resource endowment on green growth.
Women Tell All: A Comparative Thematic Analysis of Women’s Perspectives on Two Brief Counseling Interventions for Intimate Partner Violence
Authors: Shayani Danielle R. , Danitz Sara B. , Low Stephanie K. , Hamilton Alison B. , Iverson Katherine M.
Published: February 2022

Background: Intimate partner violence (IPV) is a significant public health problem that is commonly experienced by women and associated with psychosocial health issues. Recovering from IPV through Strengths and Empowerment (RISE) is a brief, clinician-administered, variable-length (1–6 sessions), modular, individualized psychosocial counseling intervention developed for women experiencing IPV. We present qualitative feedback and quantitative helpfulness ratings from women patients of the Veterans Health Administration who completed a randomized clinical trial (RCT) comparing RISE to a clinician-administered advocacy-based Enhanced Care as Usual (ECAU; a single structured session consisting of psychoeducation, safety-planning, resources, and referrals). Methods: 58 participants (Mage = 39.21) completed post-intervention semi-structured qualitative interviews, including helpfulness ratings, at two follow-up assessments (10- and 14-weeks post-enrollment) to assess the acceptability, usefulness, and perceived fit of the interventions for women’s needs. Interviews were transcribed and analyzed using a hybrid deductive-inductive analytic approach. Results: While both the RISE and ECAU interventions were deemed helpful (interventions were rated as ‘highly helpful’ by 77% of RISE and 52% of ECAU participants), differences were identified in perceived impacts of the intervention, application of content, approach to patient-centeredness, and implementation recommendations. Conclusions: Findings shed light on women Veterans’ experiences and preferences for IPV psychosocial counseling interventions. Such knowledge can inform evidence-based, trauma-informed, and individualized care for women Veterans who experience IPV and may have relevance to other populations of women who experience IPV.
Forest Attendance in the Times of COVID-19—A Case Study on the Example of the Czech Republic
Authors: Jarský Vilém , Palátová Petra , Riedl Marcel , Zahradník Daniel , Rinn Radek , Hochmalová Miroslava
Published: February 2022

The COVID-19 pandemic affected people all over the world, including the Czech Republic (CZ). In the CZ, a number of measures were applied in 2020 to reduce the contact between people and their mobility. This article dealt with the importance of forests during the pandemic. Data from 2019 and 2020 were compared. The qualitative data were obtained from two nationwide surveys, the first focused on forest attendance and forest fruit collection (about 1000 respondents per year), the second on the motivation to visit the forests (about 3700 respondents per year). The quantitative data were obtained on the regional level by analysing data from mobility counters. The impact of government restrictions was assessed. Findings: (1) there was a significant increase in the number of people who frequently visited the forest in 2020; (2) in 2020, the amount of households that collected forest fruits increased and was the highest for the monitored period; (3) the increased forest attendance significantly corresponded to the government restrictions. The analysis confirmed the great importance of forests for the citizens and, at the same time, the increased pressure on the forests’ use—forest attendance and forest crops picking—(especially suburban ones) in times of COVID-19 restrictions.
Anorexia Nervosa, Body Image Perception and Virtual Reality Therapeutic Applications: State of the Art and Operational Proposal
Authors: Magrini Massimo , Curzio Olivia , Tampucci Marco , Donzelli Gabriele , Cori Liliana , Imiotti Maria Cristina , Maestro Sandra , Moroni Davide
Published: February 2022

Anorexia Nervosa (AN) patients exhibit distorted body representation. The purpose of this study was to explore studies that analyze virtual reality (VR) applications, related to body image issues, to propose a new tool in this field. We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, EMBASE, Scopus, and Web of Science databases were explored; the review included 25 studies. Research has increased over the last five years. The selected studies, clinical observational studies (n = 16), mostly concerning patients’ population with AN (n = 14) or eating disorders (EDs) diagnosis, presented multiple designs, populations involved, and procedures. Some of these studies included healthy control groups (n = 7). Studies on community sample populations were also selected if oriented toward clinical applications (n = 9). The VR technologies in the examined period (about 20 years) have evolved significantly, going from very complex and bulky systems, requiring very powerful computers, to agile systems. The advent of low-cost VR devices has given a big boost to research works. Moreover, the operational proposal that emerges from this work supports the use of biofeedback techniques aimed at evaluating the results of therapeutic interventions in the treatment of adolescent patients diagnosed with AN.
Attention-Deficit/Hyperactivity Disorder Symptoms, Sensation-Seeking, and Sensory Modulation Dysfunction in Substance Use Disorder: A Cross Sectional Two-Group Comparative Study
Authors: Assayag Naama , Berger Itai , Parush Shula , Mell Haim , Bar-Shalita Tami
Published: February 2022

Background: Attention-deficit/hyperactivity disorder (ADHD) and sensation-seeking, a trait characterized by risk-related behaviors, have been recognized as risk factors in substance use disorder (SUD). Though ADHD co-occurs with sensory modulation dysfunction (SMD), SMD has scarcely been explored in SUD. Thus, this study aimed to characterize ADHD symptomology, sensation-seeking, and SMD, as well as to explore their contribution to SUD likelihood. Methods: A cross sectional two-group comparative study including therapeutic community residents with SUD (n = 58; study group) and healthy individuals (n = 62; comparison group) applying the MOXO continuous performance test (MOXO-CPT) evaluating ADHD-related symptoms. In addition, participants completed the ADHD Self-Report Scale—Version 1.1 for ADHD screening; the Brief Sensation Seeking Scale quantifying risk-taking behaviors; and the Sensory Responsiveness Questionnaire-Intensity Scale for identifying SMD. Results: The study group demonstrated higher SMD incidence (53.57% vs. 14.52%) and lower performance in three MOXO-CPT indexes: Attention, Impulsivity, and Hyperactivity, but not in Timing, compared to the comparison group. Sensory over-responsiveness had the strongest relationship with SUD, indicating 27-times increased odds for SUD (95% CI = 5.965, 121.216; p ≤ 0.0001). A probability risk index is proposed. Conclusion: We found SMD with the strongest relation to SUD exceeding that of ADHD, thus contributing a new perspective for developing future therapeutic modalities. Our findings highlight the need to address SMD above and beyond ADHD symptomology throughout the SUD rehabilitation.
Effect of Humin and Chemical Factors on CO2-Fixing Acetogenesis and Methanogenesis
Authors: Ha Biec Nhu , Pham Duyen Minh , Kasai Takuya , Awata Takanori , Katayama Arata
Published: February 2022

Acetogenesis and methanogenesis have attracted attention as CO2-fixing reactions. Humin, a humic substance insoluble at any pH, has been found to assist CO2-fixing acetogenesis as the sole electron donor. Here, using two CO2-fixing consortia with acetogenic and methanogenic activities, the effect of various parameters on these activities was examined. One consortium utilized humin and hydrogen (H2) as electron donors for acetogenesis, either separately or simultaneously, but with a preference for the electron use from humin. The acetogenic activity was accelerated 14 times by FeS at 0.2 g/L as the optimal concentration, while being inhibited by MgSO4 at concentration above 0.02 g/L and by NaCl at concentrations higher than 6 g/L. Another consortium did not utilize humin but H2 as electron donor, suggesting that humin was not a universal electron donor for acetogenesis. For methanogenesis, both consortia did not utilize extracellular electrons from humin unless H2 was present. The methanogenesis was promoted by FeS at 0.2 g/L or higher concentrations, especially without humin, and with NaCl at 2 g/L or higher concentrations regardless of the presence of humin, while no significant effect was observed with MgSO4. Comparative sequence analysis of partial 16S rRNA genes suggested that minor groups were the humin-utilizing acetogens in the consortium dominated by Clostridia, while Methanobacterium was the methanogen utilizing humin with H2.
Bicycle Touring 480 km in Seven Days: Effects on Body Composition and Physical Fitness—A Case Study
Authors: Zúñiga-Moreno David , Amaro-Gahete Francisco J. , Chillón Palma
Published: February 2022

Bicycle touring as a modality of physical activity that involves whole-body cardiorespiratory and metabolic functions could be a potential strategy to improve body composition and cardiorespiratory fitness. Therefore, the aim of the current study was to investigate the effects of 7-days bicycle touring activity on body composition and physical fitness. A total of 13 individuals (three women) participated in this quasi-experimental study. The participants were evaluated at baseline and were tracked for up to 12 days after the intervention. The intervention consisted of a 480 km bicycle touring route performed over 8 days. Body weight and body composition (i.e., fat mass and lean mass) were assessed using a bioelectrical impedance analyser. Physical fitness was measured using the International Fitness Scale questionnaire. We conducted a repeated-measures analysis of variance to determine changes in body weight and body composition and paired sample t-tests to analyse changes in physical fitness. Significant differences in fat mass were observed between the baseline and both post-intervention (p = 0.003) and re-test values (p = 0.031). Significant differences were also noted in lean mass between the baseline and post-intervention values (p = 0.003), whereas no significant changes were observed when compared the baseline and re-test values (p = 0.178). Significant differences were obtained in cardiorespiratory fitness when comparing the baseline with the post-intervention values (p = 0.016), whereas no significant differences were noted in general fitness, muscular strength, speed/agility, and flexibility (all p > 0.05). In conclusion, a 7-day bicycle touring intervention can significantly reduce fat mass and increase lean mass and cardiorespiratory fitness in healthy individuals.
Effectiveness of Interventions Based on Pain Neuroscience Education on Pain and Psychosocial Variables for Osteoarthritis: A Systematic Review
Authors: Ordoñez-Mora Leidy Tatiana , Morales-Osorio Marco Antonio , Rosero Ilem D.
Published: February 2022

Osteoarthritis (OA) is the most common joint condition. It affects more than 300 million people worldwide, who suffer from pain and physical disability. Objective: To determine the results of cognitive educational interventions for pain management and psychosocial variables in adults with OA. Method: A systematic review was conducted based on searches in MEDLINE, OVID, LILACS, Scopus, PEDro, OTseeker, The Cochrane Library, EBSCO, and Google Scholar. The search strategy included the main terms neuroscience education and osteoarthritis, without any re-strictions with regard to dates or study type (PROSPERO register CRD42021222763). Results: We included four articles that implemented the intervention in 1–6 sessions, addressing concepts related to goal orientation and providing strategies for understanding pain. The results suggest that there is an improvement between the groups (PNE) when compared, but this cannot necessarily be attributed to pain neuroscience education (PNE), as small effect sizes for variables such as pain catastrophizing and kinesiophobia were observed. The response in the modulation of acute pain following the surgical procedure may produce a variation in the responses and this may be mediated by medications. Conclusion: The study revealed an improvement in favor of the groups managed with PNE, although more studies documenting the topic are warranted.
Dietary Quality, Sleep Quality and Muscle Mass Predicted Frailty among Chinese Postmenopausal Women in Malaysia
Authors: Chan Kai Sze , Chan Yoke Mun , Chin Yit Siew , Mohd Shariff Zalilah
Published: February 2022

The older adult population is growing faster than any age group, which increases their risk of frailty. Studies conducted among older adult are relatively scarce in Malaysia, especially among Chinese postmenopausal women, who have the longest life expectancy. Thus, the present study aimed to determine the prevalence of frailty and its associated factors among Chinese postmenopausal women. A total of 220 eligible respondents were recruited, with information on sociodemographic background, comorbidities, dietary intake and lifestyle behaviour were obtained using a structured questionnaire, while anthropometry indicators were assessed according to standard protocol. Fasting blood was withdrawn for the analysis of serum 25(OH)D. Multinomial logistic regression was used to determine factors that predict pre-frailty and frailty. Prevalence of pre-frailty and prevalence of frailty were 64.5 and 7.3%, respectively, and most of the respondents presented with weak handgrip strength. Pre-frailty was prevalent among the younger population. Dietary quality was unsatisfactory among the respondents, and the majority of them presented with a high percentage of body fat. An increased dietary quality index (DQI), poor sleep and low muscle mass were factors that contributed to frailty. In conclusion, nutritional factors should be considered in developing health-related policies and programs in reducing and delaying the onset of frailty.
Solid-State Fermentation of Chestnut Shells and Effect of Explanatory Variables in Predictive Saccharification Models
Authors: Pinto Paula A. , Bezerra Rui M. F. , Fraga Irene , Amaral Carla , Sampaio Ana , Dias Albino A.
Published: February 2022

In this study, chestnut shells (CNS), a recalcitrant and low-value agro-industrial waste obtained during the peeling of Castanea sativa fruits, were subjected to solid-state fermentation by six white-rot fungal strains (Irpex lacteus, Ganoderma resinaceum, Phlebia rufa, Bjerkandera adusta and two Trametes isolates). After being fermented, CNS was subjected to hydrolysis by a commercial enzymatic mix to evaluate the effect of fermentation in saccharification yield. After 48 h hydrolysis with 10 CMCase U mL−1 enzymatic mix, CNS fermented with both Trametes strains was recorded with higher saccharification yield (around 253 mg g−1 fermented CNS), representing 25% w/w increase in reducing sugars as compared to non-fermented controls. To clarify the relationships and general mechanisms of fungal fermentation and its impacts on substrate saccharification, the effects of some independent or explanatory variables in the production of reducing sugars were estimated by general predictive saccharification models. The variables considered were lignocellulolytic activities in fungal fermentation, CNS hydrolysis time, and concentration of enzymatic hydrolysis mix. Multiple linear regression analysis revealed a very high significant effect (p < 0.0001) of fungal laccase and xylanase activities in the saccharification models, thus proving the key potential of these enzymes in CNS solid-state fermentation.
The Effect of Problematic Social Media Use on Happiness among Adolescents: The Mediating Role of Lifestyle Habits
Authors: Zhang Jiewen , Marino Claudia , Canale Natale , Charrier Lorena , Lazzeri Giacomo , Nardone Paola , Vieno Alessio
Published: February 2022

Background: Although the relationship between problematic social media use (PSMU) and happiness has been already explored, less is known about the mechanisms that translate PSMU into lower happiness through lifestyle habits. Therefore, the current study focuses on the association between PSMU and happiness, exploring a mediating effect of lifestyle habits (e.g., difficulties in getting to sleep and frequency of physical activity) among Italian adolescents. Methods: A total of 58,976 Italian adolescents (mean age = 13.6, SD = 1.63; age range = 10.5–16.5; 49.4% females) were included. The pattern of relationships specified by the theoretical model was examined through path analysis. Results: Difficulties in getting to sleep (β = −0.037, p < 0.001) and frequency of physical activity (β = −0.012, p < 0.001) were mediators in the relationship between PSMU and happiness. Multi-group analyses across gender and age groups (11, 13, and 15 years old) showed that the chain mediating effect of the frequency of physical activity on the difficulties in getting to sleep was not significant for females but significant for males and for all of the three age groups. Overall, females and older ages were sensitive to the whole model. Conclusion: Along with difficulties in getting to sleep and the frequency of physical activity, lifestyle habits may contribute to the association between PSMU and happiness. We also recommend that future studies focus on PSMU in females and older adolescents, as they show more general sleep problems and reduced physical activity.
Validation and Psychometric Properties of the Polish Version of the Skin Picking Scale-Revised
Authors: Kłosowska Joanna , Prochwicz Katarzyna , Sznajder Dominika , Antosz-Rekucka Rachela , Tuleja Aleksandra , Dembińska Aleksandra , Snorrason Ivar
Published: February 2022

The Skin Picking Scale-Revised (SPS-R) is an 8-item self-report measure of skin picking behaviors. It includes two subscales related to skin picking symptom severity and picking-related impairments. The study aimed to assess the psychometric properties of the Polish version of the SPS-R in a sample of adults reporting skin picking. The sample of 764 participants was recruited from the general population through an online survey. Among them, 159 meet the criteria of pathological skin picking applied in the original SPS-R validation study, and 57 endorsed all of the DSM-5 criteria for excoriation disorder. The SPS-R was back-translated into Polish. Factor structure, reliability, convergent and divergent validity, and diagnostic accuracy were assessed. Confirmatory factor analyses revealed a two-factor structure of the scale. High internal consistency and convergent and divergent validity were confirmed for the total score as well as for the subscales. High prognostic ability of the SPS-R total score was also demonstrated using ROC analysis: ≥5 was accepted as an optimal cut-off point for distinguishing skin picking sufferers from healthy controls. The Polish version of the SPS-R shows good psychometric properties and appears to be a reliable measure of skin picking symptoms and picking-related impairment.
Headphone Audio in Training Systems or Systems That Convey Important Sound Information
Authors: Mlynski Rafal
Published: February 2022

In the work environment, miniature electroacoustic transducers are often used in communication, for the transmission of warning signals or during training. They can be used in headphones or mounted in personal protective equipment. It is often important to reproduce sounds accurately. The purpose of this work was to assess audio strips by comparing the frequency response of the signal in the electrical outputs of six common-purpose devices. Based on the risk of hearing damage, the level of noise exposure was assessed. The following headphones were investigated: low-budget closed-back, open-back for instant messengers, open-back for music, and in-ear. A head and torso simulator with a transfer function was used. The most uniform shape of the frequency response of the signal at the electrical outputs was found to be in smartphones. Sound cards integrated into laptop motherboards had highly unequal characteristics (up to 23 dB). In the case of one of the laptops, the upper range of the transmitted frequencies was limited to the 12,500 Hz band. An external sound card or wireless headphones can improve the situation. In the worst-case scenario, i.e., rock music, the listening time was limited to 2 h and 18 min.
Perceptions and Profiles of Young People Regarding Spa Tourism: A Comparative Study of Students from Granada and Aachen Universities
Authors: Pinos-Navarrete Aida , Abarca-Álvarez Francisco Javier , Maroto-Martos Juan Carlos
Published: February 2022

Spa tourism has undergone important changes in recent decades, actively embracing wellness and wellbeing. However, this transition is taking place in different ways in Europe, and this has led to varying perceptions of thermalism that have little to do with its original conception. The main aim of this study was to analyse current perceptions of spa tourism amongst university students, so as to identify profiles and compare the differences between two study cases: Granada (Spain) and Aachen (Germany). For this purpose, we applied a methodology that combines artificial intelligence techniques with questionnaires containing both quantitative and qualitative variables. This enabled us to identify and characterize a series of profiles, so as to acquire detailed knowledge of the perceptions of these students regarding spa tourism in Granada and Aachen. On the basis of the results, the interviewees were grouped together into seven profiles from which we deduced that young Germans from Aachen visit spas more frequently and have a more realistic perception of the thermal sector than young Spanish people from Granada. This situation could limit present and future demand for spas in southern Spain. With this in mind, in this paper we present an updated assessment of the demand for spas amongst university students, in order to design effective geomarketing strategies in two cities with long spa traditions.
Behavioral Patterns in Breaking Bad News Communication: An Ethnographic Study with Hematologists
Authors: Artioli Giovanna , Ghirotto Luca , Alquati Sara , Tanzi Silvia
Published: February 2022

Hematologists adequately disclosing bad news is a critical point precluding patient-centered communication. Specific courses on communication for hematologists seem to be rare, as well as research exploring their communicative skills and patterns. We aim at describing the hematologists’ behavior during difficult conversations to account for behavioral patterns in communication and provide new insights regarding teaching skills to communicate bad news. We employed a focused visual ethnography to answer the following research: “what are hematologists’ behavioral patterns in communicating bad news to patients and families?” The collected data included (1) video recordings, (2) observational field notes, (3) interviews with hematologists. The analysis highlighted four patterns: (1) a technical-defensive pattern, (2) an authoritative pattern, (3) a relational-recursive pattern, and (4) a compassionate sharing pattern. Hematologists seem to have difficulty expressing compassionate caring and empathetic comprehension. Communication skills remain a challenge for hematologists. The study of behavioral patterns can lead to increasingly targeted training interventions for this specific learner population.
The Fertility of a Concept: A Bibliometric Review of Human Flourishing
Authors: Cebral-Loureda Manuel , Tamés-Muñoz Enrique , Hernández-Baqueiro Alberto
Published: February 2022

Human flourishing is a thriving concept, whose use has greatly increased among academic researchers from a variety of fields, from the arts and humanities and psychology to the social and environmental sciences and economics. To better understand the concept’s success, this work proposes a bibliometric review, in which statistical methods and data mining were used to analyze 1829 documents, chosen from the Scopus database by searching the term “human flourishing”. Through cluster and network analyses, the study shows the concept’s evolution and composition, as well as its current tensions and trends, in which the predominantly psychological approach is being compensated with social concerns and the search for justice. Furthermore, the concept’s strong philosophical roots provide it with abstract richness and great fertility, which can be seen in keywords, such as virtue or eudaimonia. This bibliometric review proved to be useful for this type of study, despite the limitations imposed by the characteristics of the Scopus database itself.
Road Network Generalization Method Constrained by Residential Areas
Authors: Lyu Zheng , Sun Qun , Ma Jingzhen , Xu Qing , Li Yuanfu , Zhang Fubing
Published: February 2022

Residential areas and road networks have a strong geographical correlation. The development of a single geographical feature could destroy the geographical correlation. It is necessary to establish collaborative generalization models suitable for multiple features. However, existing road network generalization methods for mapping purposes do not fully consider residential areas. Compared with road networks, residential areas have a higher priority in cartographic generalization. In this regard, this study proposes a road network generalization method constrained by residential areas. First, the roads and settlements obtained from clustering residential areas were classified. Next, the importance of the settlements was evaluated and certain settlements were selected as the control features. Subsequently, a geographical network with the settlements as the nodes was built, and the traffic paths between adjacent settlements were searched. Finally, redundant paths between the settlements were simplified, and the visual continuity and topological connectivity were checked. The data of a 1:50,000 road network and residential areas were used as the experimental data. The experimental results demonstrated that the proposed method preserves the overall structure and relative density characteristics of the road network, as well as the geographical correlation between the road network and residential areas.
(Of) Indigenous Maps in the Amazon: For a Decolonial Cartography
Authors: Breda Thiara Vichiato
Published: February 2022

There are mappings of indigenous lands, mappings with indigenous participation, and mappings made by indigenous people, all of them resulting from cartographic intentions, mapping motives, and distinct meanings of spatiality. Starting from the questioning around the drives of the subject towards his search for knowledge of the space and its mapping, this article seeks to both identify the key points that these three types of mapping typically resemble and intersect, as well as to distinguish and debate them while highlighting maps made by indigenous people. This approach is based on interpretations of Mebêngôkre (Kayapó) and A’uwe (Xavante) mappings, seeking to understand them as a device of spatial organizations and representations. In doing so, we (re)position indigenous peoples as cartographer subjects who possess and produce cartographic/geographic knowledge while we question the Eurocentric legacy, expressed in an exclusivity of official/academic cartography.
Actions of Bisphenol A on Different Feto-Maternal Compartments Contributing to Preterm Birth
Authors: Vidal Manuel S. , Menon Ramkumar , Yu Gracia Fe B. , Amosco Melissa D.
Published: February 2022

Preterm birth remains to be one of the most prevalent obstetric complications worldwide. Since there are multiple etiological factors associated with this disease process, an integrative literature search in PubMed and Scopus databases on possible mechanism of action and effect of bisphenols on exposure on human or animal placental samples in preterm birth was conducted. From 2332 articles on initial literature search, 63 studies were included for full data extraction. Altogether, several pathways were shown to be possibly affected by bisphenols, leading to dysregulations in structural and endocrine foundation in the placenta, potential induction of senescence and failure of decidualization in the decidua, and possible propagation of inflammation in the fetal membranes. Combined, these actions may eventually counteract bisphenol-induced relaxation of the myometrium and promote contractility alongside fetal membrane weakening. In totality, these individual impairments in gestation-critical processes may lead to failure of maintenance of pregnancy, and thus effecting preterm birth.
Manipulating the Level of Sensorimotor Stimulation during LI-rTMS Can Improve Visual Circuit Reorganisation in Adult Ephrin-A2A5-/- Mice
Authors: Poh Eugenia Z. , Green Courtney , Agostinelli Luca , Penrose-Menz Marissa , Karl Ann-Kathrin , Harvey Alan R. , Rodger Jennifer
Published: February 2022

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that has the potential to treat a variety of neurologic and psychiatric disorders. The extent of rTMS-induced neuroplasticity may be dependent on a subject’s brain state at the time of stimulation. Chronic low intensity rTMS (LI-rTMS) has previously been shown to induce beneficial structural and functional reorganisation within the abnormal visual circuits of ephrin-A2A5-/- mice in ambient lighting. Here, we administered chronic LI-rTMS in adult ephrin-A2A5-/- mice either in a dark environment or concurrently with voluntary locomotion. One day after the last stimulation session, optokinetic responses were assessed and fluorescent tracers were injected to map corticotectal and geniculocortical projections. We found that LI-rTMS in either treatment condition refined the geniculocortical map. Corticotectal projections were improved in locomotion+LI-rTMS subjects, but not in dark + LI-rTMS and sham groups. Visuomotor behaviour was not improved in any condition. Our results suggest that the beneficial reorganisation of abnormal visual circuits by rTMS can be significantly influenced by simultaneous, ambient visual input and is enhanced by concomitant physical exercise. Furthermore, the observed pathway-specific effects suggest that regional molecular changes and/or the relative proximity of terminals to the induced electric fields influence the outcomes of LI-rTMS on abnormal circuitry.
Chronic Monocular Deprivation Reveals MMP9-Dependent and -Independent Aspects of Murine Visual System Plasticity
Authors: Murase Sachiko , Robertson Sarah E. , Lantz Crystal L. , Liu Ji , Winkowski Daniel E. , Quinlan Elizabeth M.
Published: February 2022

The deletion of matrix metalloproteinase MMP9 is combined here with chronic monocular deprivation (cMD) to identify the contributions of this proteinase to plasticity in the visual system. Calcium imaging of supragranular neurons of the binocular region of primary visual cortex (V1b) of wild-type mice revealed that cMD initiated at eye opening significantly decreased the strength of deprived-eye visual responses to all stimulus contrasts and spatial frequencies. cMD did not change the selectivity of V1b neurons for the spatial frequency, but orientation selectivity was higher in low spatial frequency-tuned neurons, and orientation and direction selectivity were lower in high spatial frequency-tuned neurons. Constitutive deletion of MMP9 did not impact the stimulus selectivity of V1b neurons, including ocular preference and tuning for spatial frequency, orientation, and direction. However, MMP9−/− mice were completely insensitive to plasticity engaged by cMD, such that the strength of the visual responses evoked by deprived-eye stimulation was maintained across all stimulus contrasts, orientations, directions, and spatial frequencies. Other forms of experience-dependent plasticity, including stimulus selective response potentiation, were normal in MMP9−/− mice. Thus, MMP9 activity is dispensable for many forms of activity-dependent plasticity in the mouse visual system, but is obligatory for the plasticity engaged by cMD.
Human-Computer Interaction in Digital Mental Health
Authors: Balcombe Luke , De Leo Diego
Published: February 2022

Human-computer interaction (HCI) has contributed to the design and development of some efficient, user-friendly, cost-effective, and adaptable digital mental health solutions. But HCI has not been well-combined into technological developments resulting in quality and safety concerns. Digital platforms and artificial intelligence (AI) have a good potential to improve prediction, identification, coordination, and treatment by mental health care and suicide prevention services. AI is driving web-based and smartphone apps; mostly it is used for self-help and guided cognitive behavioral therapy (CBT) for anxiety and depression. Interactive AI may help real-time screening and treatment in outdated, strained or lacking mental healthcare systems. The barriers for using AI in mental healthcare include accessibility, efficacy, reliability, usability, safety, security, ethics, suitable education and training, and socio-cultural adaptability. Apps, real-time machine learning algorithms, immersive technologies, and digital phenotyping are notable prospects. Generally, there is a need for faster and better human factors in combination with machine interaction and automation, higher levels of effectiveness evaluation and the application of blended, hybrid or stepped care in an adjunct approach. HCI modeling may assist in the design and development of usable applications, and to effectively recognize, acknowledge, and address the inequities of mental health care and suicide prevention and assist in the digital therapeutic alliance.
Bio-Wastes as Aggregates for Eco-Efficient Boards and Panels: Screening Tests of Physical Properties and Bio-Susceptibility
Authors: Cintura Eleonora , Faria Paulina , Duarte Marta , Nunes Lina
Published: February 2022

Screening tests were developed or adapted from RILEM recommendations, standards and past studies, and carried out to characterize some agro-industrial wastes and to assess their feasibility as aggregates for eco-efficient building composites. Spent coffee grounds, grape and olive press waste and hazelnut shells were used, as well as maritime pine chips as control material. Particle size distribution, loose bulk density, thermal conductivity and hygroscopicity properties were analysed. The selected bio-wastes did not show good thermal insulation properties if compared with some bio-wastes already studied and used for thermal insulation composites. Values of loose bulk density and thermal conductivity were between 325.6–550.5 kg/m3 and 0.078–0.107 W/(m·K); moisture buffering values higher than 2.0 g/(m2·%RH). Biological susceptibility to mould and termites were also tested, using not yet standardized methods. The low resistance to biological attack confirms one of the greatest drawbacks of using bio-wastes for building products. However, final products properties may be changed by adding other materials, pre-treatments of the wastes and the production process.