bluuebunny/crossref_metadata_2025 huggingface dataset:
Schistosomes from the Persian Gulf: phylogenetic relationships, host associations and life-cycle elucidation of Ornithobilharzia canaliculata (Rudolphi, 1819) Odhner, 1912
Authors: Khosravi Maral , Thieltges David W. , Shamseddin Jebreil , Georgieva Simona
Published: March 2022

Background
Avian schistosomes comprise a diverse and widespread group of trematodes known for their surprising ability to switch into new hosts and habitats. Their cercariae are the causative agents of the waterborne allergic disease cercarial dermatitis. There are 13 recognised genera of avian schistosomes with majority of the extant species with freshwater-based life-cycles. Despite the considerable research attention on avian schistosomes much less it is known about the diversity, geographical range and host associations of the marine representatives. Here, we provide novel data on the species diversity and host-parasite relationships of the marine schistosomes in respect to their intermediate gastropod host from the Persian Gulf.
Methods
A total of 1,745 horn snails of Pirenella cingulata (Gmelin), were examined during a survey from December 2019 to February 2020 from eight distinct locations along the coast of Iran. Partial sequences of the mitochondrial cytochrome c oxidase subunit 1 (cox1) and the nuclear 28S rRNA gene were generated for the schistosome isolates recovered and used for molecular identification and phylogenetic reconstruction.
Results
Our molecular analyses inferred from both molecular markers revealed presence of two schistosome species, Ornithobilharzia canaliculata (Rudolphi, 1819) Odhner, 1912 and a putative new species of Austrobilharzia Johnston, 1917. Molecular elucidation of the life-cycle of O. canaliculata was achieved for the first time via matching novel and published sequence data from adult and larval stages. This is the first record of Ornithobilharzia from the Persian Gulf and globally the first record of this genus in a potamidid snail host.
Conclusions
The present study provides new host and distribution records for major etiological agents of cercarial dermatitis and contributes important information on host-parasite relationships. Our study further highlights the importance of the molecular systematics in the assessment of schistosome diversity and calls for further surveys in order to reach a better understanding of the schistosome diversity and patterns of relationships among them, host associations, transmission strategies and distribution coverage.
Low acceptance of illness with inflammatory bowel disease tending to receive fecal microbiota transplantation
Authors: Liu Rong , Luo Fameng , Tao Dezhi , Luo Jincuo , Zhang Guimei , Wang Chenyang , Zhang Haiyan
Published: March 2022

Background
Fecal microbiota transplantation(FMT) can improve and reestablish the normal function of intestinal flora. It has been shown to have great potential in the treatment of inflammatory bowel disease(IBD).
Objective
To assess the current status and analyse the factors influencing the acceptance of FMT treatment in IBD patients.
Methods
IBD patients were recruited at the Inflammatory Bowel Disease Center in Yunnan Province, China. Participants voluntarily completed a self-designed questionnaire and a Chinese version of the Acceptance of illness Scale(AIS) test under the premise of informed consent, to assess their attitudes toward FMT and acceptance of illness.
Results
Of the 310 patients surveyed, 70.6% and 29.4% have diagnosed ulcerative colitis and Crohn's disease respectively. Less than half of IBD patients (43.55%) were willing to undergo FMT, 2.90% refused, and 53.55% were unsure about it.The most preferred routes of FMT among IBD patients were oral fecal capsules (50.97%) and colonoscopy (21.94%). In addition, prior knowledge of FMT (OR = 3.986, 95% CI: 2.304–6.896, P < 0.001), previous experience with FMT (OR = 12.505, 95% CI: 2.454–63.717, P = 0.002) and illness acceptance (OR = 0.951, 95% CI: 0.917–0.987. P = 0.029) were independent influences on the acceptance of FMT treatment in patients with IBD.
Conclusion
This study suggested that the acceptance of FMT treatment with IBD patients still needs to be improved, and the confidence of treatment may be enhanced by strengthening cognition and sharing the surrounding successful cases with FMT treatment. Furthermore, attention should also be paid to patients with low acceptance of illness with IBD patients, which may be a potential population for FMT treatment.
Intensification of CO2 absorption and desorption by metallic and non-metallic nanoparticles in bubble columns
Authors: zarei Fariba , Keshavarz Peyman
Published: March 2022

In this study, four different metallic and non-metallic nanoparticles including CuO, Fe3O4, ZnO and SiO2 were employed to improve CO2 absorption and desorption in MDEA-based nanofluid. CO2 absorption experiment with various nanofluids was done in a bubble column reactor at ambient temperature. Also, CO2 stripping experiments for all nanofluids were done at 60 and 70 oC. The influence of nanoparticles type, nanoparticle concentration, and the stability of nanoparticles were studied on both CO2 absorption and stripping. The obtained results revealed that Fe3O4 nanoparticles at 0.01 wt.% concentration had the best influence on CO2 absorption and it improved the CO2 loading up to 36%. Also, CO2 stripping experiments for all nanofluids were done at 60 and 70 oC. The desorption experiments illustrated that metallic nanoparticles can be more efficient in improving CO2 desorption. In CO2 desorption, the CuO nanoparticles at 0.05 wt.% had higher efficiency, and enhanced CO2 concentration at outlet gas phase up to 44.2 vol.% at 70 oC.
Level Of Physical Activity And Nutritional Status (Bmi): A Comparative Study Between Urban And Rural Adolescents In The Northern Region
Authors: ABUBAKARI ABDULAI , YUSSIF RAMATU , ZIBLIM YAKUBU IDDI
Published: March 2022

Dietary patterns and physical activity, in addition to countervailing social norms, that influence health and nutritional well-being of adolescents are increasingly becoming important in recent times. This study was conducted to compare the level of physical activity and its relationship with nutritional status (BMI) among rural and urban adolescents in the Northern Region. The study employed an analytical cross-sectional study design. The study used random sampling technique to sample 520 adolescents. The study administered a questionnaire on the respondents and the data analyzed using Statistical Package for Social Sciences version 23.0 and Microsoft word excels 2013. The study showed that, 9.4% of the urban dwellers were too thin for their age relative to 5.4% of the rural folks. Overweight/obese prevalence was 7.9% among the rural adolescents compare to 8.3% of the adolescents living in the urban areas. From the results, 52.9% of the urban adolescents had low physical activity compared to 43.9% of the rural adolescents. A multinomial logistic regression with reference to people engaging in moderate physical activities reveals that male’s adolescent are more than two (2) times (RRR: 2.24, 95% CI: 1.133-4.404, P-value: 0.02) more likely to engage in high physical activities than female adolescents. Adolescents whose fathers had up-to primary education only were found to be more than 13% less likely to engage in moderately physical activities than those whose fathers attended junior high school (RRR; 0.134, 95% CI; 0.0022-0.827, P-value; 0.03). Based on the results, it was concluded that adolescents were moderately engaged in some form of physical activity and this could explain why overweight/obesity was low among the study population. The study recommends that, parents and guardians as well as health workers and teachers encourage adolescents to continue with daily physical activities in order to sustain their physical activity levels.
Spatio-temporal pattern of congenital hypothyroidism screening success in Iran (Case study, Fars counties during 2005-2013)
Authors: Goli Ali , Mohtaram Nematollahi , Razieh Sharifi , Sharifiyan Roxsana
Published: March 2022

Objective: 1) Spatio-temporal analysis of CH screening success in Fars counties during 2005-2013; 2) To analyze Neonatal CH clusters in Fars counties during 2005-2013; and 4) Help to provide better planning budget and facilities for Disease Control of CH in the study area and other regions.Results: The results of this study showed that the incidence of disease duration was variable from 2 to 10 in every 1,000 newborn boys more than girls in the rate. Also, the spatial distribution pattern of CH in newborns in the period studied based on the statistical significance level (p-value) and the index of spatial autocorrelation (Moran 's I) had a random pattern. This result can identify factors involved in disease in order to better planning in the field budget and facilities needed for Disease Control and CH in the Fars province are very helpful. In different geographical areas of the province, the analysis of the spatial distribution of CH in newborns every year to show differences and show a uniformity pattern decrease and tend to focus on specific areas of space that may be the pattern (focus spatial) happen in the next few years.
Immediate Impact of Mindfulness-Based Cognitive Therapy on Women with Breast Cancer: A Systematic Review and Meta‐analysis
Authors: Chang Yun-Chen , Chang Yuh-Ming
Published: March 2022

Background
Mindfulness-based cognitive therapy (MBCT) may have positive physiological and psychological benefits for patients with breast cancer, in addition to enhancing their quality of life. However, few studies have involved synthesis of the relevant literature to confirm these effects. This meta-analysis examined the associations between MBCT and various symptoms after Western medicine–based drug treatment.
Methods
This study considered randomized controlled trials (RCTs) as well as non-RCTs comparing MBCT interventions and control protocols for the alleviation of symptoms among women with breast cancer. We calculated pooled mean differences (MDs), standardized mean differences (SMDs), and 95% confidence intervals (CIs) by using random effects models to estimate summary effect sizes.
Results
Thirteen RCTs and non-RCTs with 20–245 participants were considered in our systematic review; for our meta-analysis, 11 of these studies were eligible for assessment. The pooled meta-analysis results revealed that at the end of the MBCT intervention, participants’ anxiety (SMD, − 0.70; 95% CI, − 1.26 to − 0.13; I2 = 69%), pain (SMD, − 0.64; 95% CI, − 0.92 to − 0.37; I2 = 0%), and depression (SMD, − 0.65; 95% CI, − 1.14 to − 0.17; I2 = 75%) levels had significantly decreased, and their mindfulness (MD, 8.83; 95% CI, 3.88 to 13.78; I2 = 68%) levels significantly increased.
Conclusion
Our results suggest that MBCT is highly beneficial and cost-effective as an intervention for patients who have received treatment for breast cancer.
Evaluation and Limitations of Different Approaches Among COVID-19 Fatal Cases Using Whole-exome Sequencing Data
Authors: Forgacova Natalia , Holesova Zuzana , Hekel Rastislav , Sedlackova Tatiana , Pos Zuzana , Krivosikova Lucia , Janega Pavol , Kuracinova Kristina Mikus , Babal Pavel , Radvak Peter , Radvanszky Jan , Gazdarica Juraj , Budis Jaroslav , Szemes Tomas
Published: March 2022

Background: COVID-19 caused by SARS-CoV-2 infection may result in various disease symptoms and severity, ranging from asymptomatic, through mild, up to very severe and fatal cases. Although environmental, clinical, and social factors play important roles in both susceptibility to SARS-CoV-2 infection and COVID-19 disease progress, it is becoming evident that both pathogen and host genetic factors are important too. Here we report whole-exome sequencing (WES) findings of 27 individuals who died as a result of COVID-19 infection, especially focusing on frequencies of DNA variants in genes previously associated with SARS-CoV-2 infection and COVID-19 severity. Results: We selected risk DNA variants/alleles or target genes using four different approaches: 1) aggregated GWAS results from the GWAS Catalog; 2) selected publications from PubMed; 3) the aggregated results of the Host Genetics Initiative database; and 4) a commercial DNA variant annotation/interpretation tool providing its own knowledgebase. We divided these variants/genes into those reported to influence the susceptibility to SARS-CoV-2 infection and those influencing COVID-19 severity. Based on these, we compared frequencies of alleles among the fatal COVID-19 cases to frequencies identified in two population control datasets (non-Finnish European population from the gnomAD database and genomic frequencies specific for the Slovak population from our own database). Our comparisons delineated a trend of higher frequencies of severe COVID-19 associated risk alleles among fatal COVID-19 cases, when compared to both control population datasets. This trend reached statistical significance specifically when using the HGI derived variant list. We also analyzed other approaches to WES data evaluation, where we showed their usage as well as limitations. Conclusions: Although our results proved the likely involvement of host genetic factors pinned out by previous studies for COVID-19 disease severity, careful considerations about the molecular-testing strategies and the evaluated genomic positions may have a strong impact on the utility of genomic testing.
TMBIM1 promotes EMT by stimulating autophagic degradation of E-cadherin via AMPK/mTOR/ULK1 axis in human gliomas
Authors: Gao Lun , Liu Junhui , Zhang Shenqi , Li Yong , Tan Yinqiu , Yang Ji’an , Cai Jiayang , Wang Long , Yuan Fan’en , Ye Zhang , Tong Shi’ao , Liu Baohui , Tian Daofeng , Deng Gang , Chen Qianxue
Published: March 2022

Background Gliomas are the most common malignant tumors of the central nervous system in adults, glioblastoma is notorious for its highly metastatic and recurrent, accounting for approximately 50% of all gliomas. Exploring its molecular mechanism is urgently needed for the treatment and prognosis evaluation of gliomas. Transmembrane BAX inhibitor motif-containing 1 (TMBIM1) has been reported to be associated with non-alcoholic steatohepatitis, tumor and other diseases. However, the role of TMBIM1 in GBM and the underlying mechanisms remains unclear.MethodsThe expression level and prognostic value of TMBIM1 in gliomas were investigated by public datasets, and further confirmed by western blot and immunohistochemistry (IHC) in our tissues. Intracranial xenograft model, IHC and western blot were used to evaluate the functional role of TMBIM1.ResultsTMBIM1 was over-expressed in GBM, and its high expression reduced the survival time of glioma patients. TMBIM1 induced EMT and autophagy, and inhibition of autophagy reverses TMBIM1-regulated EMT in vitro and in vivo. Intracranial xenograft model showed the survival time of mice in TMBIM1 knockdown group treated with chloroquine (CQ)was significantly prolonged. The loss of E-cadherin expression is considered the foundation of EMT, and we subsequently demonstrated that TMBIM1 stimulating autophagic degradation of E-cadherin via AMPK/mTOR/ULK1 axis. ConclusionOur study provides a novel mechanism for the regulation of EMT in the process of gliomas metastasis, indicating that inhibition of TMBIM1 activity to attenuate autophagy may be a potential strategy for the treatment of gliomas.
Length doesn´t play a role – Sexual Activity in Men After Short Stem Total Hip Arthroplasty
Authors: Navas Luis , Hauschild Matthias , Miehlke Wolfgang , Schmidt Sebastian , Streit Marcus , Kinkel Stefan , Zimmerer Alexander
Published: March 2022

BackgroundChronic hip pain due to osteoarthritis or hip dysplasia has been shown to negatively affect many daily life aspects. One aspect, however, which persists underestimated is sexual health. The number of total hip arthroplasties (THA) are increasing, especially in young patients who have high functional expectations, not only to pain relief, but to an increase in hip mobility and quality of life as well as sexual activity.Aim(1) to report the demographic factors, (2) the sexual activity before and after THA, as well as the concerns related to sexual activity after THA and (3) the patient-reported outcome measurements (PROMs) in sexually active male patients.MethodsWe evaluated the results of patients between 18 and 65 years of age following primary cementless short femoral stem THA using a direct anterior approach (DAA) at a midterm follow-up of 4 years. A web-based questionnaire (via SurveyMonkeyâ) was chosen to assess frequency, positions, complaints, fears, dealing with the questions and PROMs. Our patients sexual activity was via The Sexual Health Inventory for Men (SHIM) validated.ResultsPatients resumed their sexual activities after 6 weeks. The two main causes of difficulty in sexual activity before surgery were pain and limitation of the range of motion of the hip joint. Patients experienced less pain and an improvement in hip range of motion after THA. 89% of patients expressed a desire for more detailed and specific information on the subject. After 4 years follow-up our patients presented a significant improvement of the modified Harris Hip Score (mHHS) from 34.1 preoperative to 92.6 after THA.Strengths and LimitationsThe use of a web-based questionnaire showed a response quote of 78.3%, which is one of the highest (30 – 80%) in relation to its peers. First the option of closed answers is a limitation because patients may interpret the questions differently. Second, we included only patients who underwent uncemented short femoral stem THA using a DAA. ConclusionTHA improves the quality in sexual life, in relation to less pain and improvement in the range of motion, but not in the frequency of sexual activity.
Openvar: Functional Annotation Of Variants In Non-Canonical Open Reading Frames
Authors: Brunet Marie A , Leblanc Sébastien , Roucou Xavier
Published: March 2022

Background: Recent technological advances have revealed thousands of functional open reading frames (ORF) that have eluded reference genome annotations. These overlooked ORFs are found throughout the genome, in any reading frame of transcripts, mature or non-coding, and can overlap annotated ORFs in a different reading frame. The exploration of these novel ORFs in genomic datasets and of their role in genetic traits is hindered by a lack of software. Results: Here, we present OpenVar, a genomic variant annotator that mends that gap and fosters meaningful discoveries. To illustrate the potential of OpenVar, we analysed all variants within SynMicDB, a database of cancer-associated synonymous mutations. By including non-canonical ORFs in the analysis, OpenVar yields a 33.6-fold, 13.8-fold and 8.3-fold increase in high impact variants over Annovar, SnpEff and VEP respectively. We highlighted an overlapping non-canonical ORF in the HEY2 gene where variants significantly clustered.Conclusions: OpenVar integrates non-canonical ORFs in the analysis of genomic variants, unveiling new research avenues to better understand the genotype-phenotype relationships.
Research on the mechanism of emotional design in Chinese cultural and creative products
Authors: Feng Xin , Yu Lei , Wang Jingya , Kong Weixin , Chen Weiqing
Published: March 2022

The empowerment of design for cultural and creative products in the digital media era is further amplified by social media platforms,its emotional and subconscious impact on users is important and profound. In addition, the integration of cultural creativity into emotional design will become an important way to enhance regional and national cultural confidence. It is easy to see that product design with unique emotional design features will become an important driver of market development, but the research on the mechanism of the role of emotional design in cultural and creative products is still not clear and explicit.the paper compares four winning entries in the Cultural and Creative Product Design Competition and four commercial products in online stores through 176 valid questionnaires. The paper uses structural equations to analyze whether these criteria are accepted by consumers and the market, and whether there is a perception gap between the two .
Bronchial Thermoplasty Attenuates Cough Reflex Sensitivity in Severe Asthma: A Single-Center Retrospective Study with 2-year Follow-up
Authors: Hara Johsuke , Yamamura Kenta , Sakai Tamami , Kobayashi Takafumi , Ohkura Noriyuki , Watanabe Satoshi , Tambo Yuichi , Sone Takashi , Kimura Hideharu , Abo Miki , Kasahara Kazuo , Yano Seiji
Published: March 2022

Despite the relatively short follow-up period in our previous study, we had reported that increased cough reflex sensitivity (CRS) may predict the efficacy of bronchial thermoplasty (BT) for treating asthma. Herein, we examined whether CRS predicts the efficacy of BT 2 years after the final BT treatment. We also investigated the influence of BT on CRS. We reviewed 12 patients 2 years after their final BT treatment. CRS, asthma-related symptoms, asthma exacerbations, and cough-related quality of life were assessed at baseline and 2 years after BT. Six patients responded positively to BT (BT responders) and their asthma control improved. No significant difference in CRS at baseline was detected between the BT responders and nonresponders. In contrast, BT responders exhibited significant improvements in CRS 2 years after BT. CRS at baseline could not predict the BT efficacy after 2 years. This is the first report demonstrating BT desensitized CRS in consecutive case series.
Non-Surgical Management of the Gingival Smile with Botulinum Toxin A. A Systematic Review and Meta-Analysis.
Authors: Rojo-Sanchis Carolina , Montiel-Company José María , Tarazona-Álvarez Beatriz , Peiró-Guijarro María Aurora , Haas-Junior Orion Luiz , Guijarro-Martínez Raquel
Published: March 2022

Due to its aesthetic implications, gummy smile is a common reason for consultation. When it is caused by a vertical excess of the maxilla, the ideal solution is orthognathic surgery. However, in borderline cases and when the cause is hyperactivity of the upper lip levator muscle complex, alternative conservative solutions can be considered, such as the application of botulinum toxin A (BTX-A). The main objective of this systematic review and meta-analysis is to analyze the effectiveness of BTX-A in the treatment of gummy smile in short and medium term, to study its stability and to evaluate potential complications. A thorough search of the PubMed, Scopus, Embase, Web of Science and Cochrane databases and a grey literature search were conducted. The inclusion criteria were: studies with a sample size greater than or equal to 10 patients with gingival exposure greater than 2 millimeters in smile, treated with BTX-A infiltration. The benefit of BTX-A in terms of improvement of gummy smile is demonstrated, a statistically significant reduction in gummy smile is estimated by BTX-A therapy two weeks after its application. Its results gradually decrease over time, however they remain satisfactorily without returning to their initial values ​​after 12 weeks.
Person Identification by Evaluating Gait using 2D LiDAR and Deep Neural Network
Authors: Hasan Mahmudul , Hanawa Junichi , Goto Riku , Fukuda Hisato , Kuno Yoshinori , Kobayashi Yoshinori
Published: March 2022

Video-based recognition techniques are solemnly effective, and it comes to a new era of research nowadays. Yet again, it suffers some bottlenecks indeed. Situations, surroundings, and momentums may be disgraceful with all new inventions. So, to solve the drawbacks of technology is to imply a new technology on it. Biometric features are very authentic and high valued measures for human identifications. Most of the techniques are dependent on close contact with the subject. A gait is a pattern that performs by walking from the individual. Almost all studies of gait-based person identifications are performed by RGB or RGB-D cameras. Very few studies were done by using LiDAR data. Applying 2D LiDAR images for individual tracking and identification is superb when video surveillances fail to perform accurately due to environmental and imposed difficulties (i.e., disaster, rain, fog, smoke, snow, occlusion, cost, etc.). This research performed a comprehensive exhibition of 2D LiDAR data with a rigorous self-made dataset and customized residual neural network. We considered different experimental setups and found exciting precisions there. Our system is appropriate for recognizing a person based on his ankle level 2D LiDAR data.
Ataluren Prevented Bone Loss Induced by Ovariectomy and Aging in Mice Through the BMP-SMAD Signaling Pathway
Authors: Zeng Lijun , Gu Ranli , Shao Yuzi , Zhu Yuan , Xie Zhengwei , Liu Hao , Zhou Yongsheng
Published: March 2022

BackgroundBoth estrogen deficiency and aging may lead to osteoporosis. Developing novel drugs for treating osteoporosis is a popular research direction. Ataluren (ATA) is a nonaminoglycoside nonsense mutation inhibitor currently used clinically to treat muscular atrophy and Duchenne muscular dystrophy. However, little attention has been given to the role of Ataluren in osteogenesis, and it is unclear whether Ataluren can improve osteogenic differentiation of human- derived bone marrow mesenchymal stem cells (hBMMSCs) and treat osteoporosis.MethodsIn this study, we screened several potential therapeutic agents through a new deep learning-based efficacy prediction system (DLEPS) using transcriptional profiles for osteoporosis. We used ovariectomized (OVX) and aged female C57BL6 mice as bone loss models to demonstrate the role of preventing bone loss for Ataluren. The osteogenic differentiation of hBMMSCs was verified via qRT–PCR, staining and quantification of alkaline phosphatase and alizarin red S, and western blotting (WB), with and without an inhibitor of the BMP-SMAD signaling pathway and siBMP2. ResultsDLEPS screening led to a potential novel drug examinee, ataluren, for treating osteoporosis. Ataluren significantly reversed bone loss in ovariectomized mice. Next, ataluren significantly increased human bone marrow-derived mesenchymal stem cell (hBMMSC) osteogenic differentiation without cytotoxicity, indicated by the high expression index of osteogenic differentiation genes (OCN, BGLAP, ALP, COL1A, BMP2, RUNX2). Mechanistically, ataluren exerted its function through the BMP–SMAD pathway. Furthermore, it activated SMAD phosphorylation but osteogenic differentiation was attenuated by BMP2–SMAD inhibitors or small interfering RNA of BMP2. Finally, ataluren significantly reversed bone loss in aged mice. ConclusionsIn summary, our findings suggest that the DLEPS-screened ataluren may be a therapeutic agent against osteoporosis by aiding hBMMSC osteogenic differentiation.
Assessing The Low-Carbon City Pilot Policy On Carbon Emission From Consumption And Production In China: How Underlying Mechanism And Spatial Spillover Effect?
Authors: Ren Huimin , Gu Guofeng , Zhou Honghao
Published: March 2022

With the acceleration of industrialization and urbanization, China’s greenhouse gas emissions have gradually become one of the major constraints to its sustainable development. As a comprehensive environmental regulation policy, Low-carbon city pilot (LCCP) policy is widely used to mitigate carbon dioxide emissions and guide low-carbon development in China. Based on the panel data of 285 cities from 2003 to 2019 in China, this study mainly applied the staggered DID method to examine the effects of LCCP policy on carbon intensity (CI) and carbon emission per capita (CP) from production and consumption perspectives. The textual quantification and spatial DID method were also employed to explore the mechanism, heterogeneity and spatial spillover effect in an integrated manner. Our results show that: (1) The LCCP policy effectively reduced CI and CP, but these effects did not appear until the third year of implementation. The above conclusions passed a series of robustness and endogeneity tests. (2) Reducing industrial emission, improving technological innovation and optimizing the efficiency of energy usage were three important mechanisms to reduce CI and CP, validating the effectiveness of the LCCP policy. (3) Command-mandatory and voluntary LCCP policy tools achieved better results and the LCCP policy exerted a significant emission reduction effect on second-tier pilot cities as compared to others. (4) This abatement effect of LCCP policy had also demonstrated a spatial spillover impact on neighboring cities. Findings from this study provide empirical evidence for the promotion of low-carbon city pilots and offer a replicable and effective path to implement environmental regulation.
Clinical Analysis of Bronchoscope Diagnosis and Treatment for Airway Foreign Body Removal in Pediatric Patients
Authors: Han Lin-lin , Zhang Zhong-xiao , Tang Xiao-di , Ma Jing , Meng Chen , Li Chang-xiao
Published: March 2022

Background: With the wide application and technical development of flexible and rigid bronchoscopy, the method of removing airway foreign body has developed from the single use of foreign body forceps to different techniques for different foreign bodies.Methods:Selected 633 children who were diagnosed as airway foreign bodies by the Department of Respiratory Intervention, Children's Hospital affiliated to Shandong University from January 1, 2018 to December 31, 2021, and the airway foreign bodies were diagnosedvia bronchoscopy. After comprehensive evaluation about the nature of the foreign body in the airway, removed the foreign body with the foreign body forceps, freezing, laser, electrocoagulation, balloon and other techniques, observed the success rate of the foreign body removed from the airway, the percentage of the foreign body removed using different techniques, the operation time, and the incidence of post-adverse reactions during operation.Results:The success rate of using flexible bronchoscope alone to remove foreign bodies in the airway was 99.2%. After flexible bronchoscopy, 19 cases of foreign bodies were removed by vacuum suction alone, 513 cases were removed by foreign body forceps alone, 62 cases were combined with cryotherapy, 2 cases were electrocoagulation, 6 cases weremesh baskets, 3 cases were balloons, 5 cases were laser, and various 18 cases of foreign bodies were taken out by technical combination. 5 cases of flexible bronchoscope combined with rigid bronchoscope combined to remove foreign bodies. The operating time ranges from 5min-1h, with an average of 20minutes.There were 17 cases of hypoxemia (2.7%) during the operation, 36 cases (5.7%) of bleeding caused by airway mucosa injury after the treatment, and 70 cases (11.2%) of laryngeal edema. The total incidence of adverse reactions was 19.6%, there were no deaths due to foreign bodies and treatment.Conclusions According to the different properties of airway foreign bodies, it is safe and effective to select appropriate techniques to extract foreign bodies through the flexible bronchoscope, which can increase the removal rate of airway foreign bodies and reduce the occurrence of serious complications.
Cervical Bleeding with Cervical Stabilization During IUD Placement: Allis Clamp Versus Single-Tooth Tenaculum
Authors: Andrews Brooke , Quick Kristen , MacLeod Erin , Edwards Kayce , Rone Bryan
Published: March 2022

OBJECTIVETo evaluate whether the use of an atraumatic Allis clamp will result in less bleeding than the standard single-tooth tenaculum for cervical stabilization during intrauterine device (IUD) placement.METHODSA single blinded randomized controlled trial was conducted during insertions of IUDs between March 2017 and March 2018. University of Kentucky Institutional Review Board (IRB 16-1110-P3K) approval was obtained. Physicians were randomized to use either an Allis clamp or a single-tooth tenaculum for cervical stabilization. A post-procedure questionnaire was used to collect outcome measures as well as demographic and obstetric related factors.RESULTSOf the ninety-five participants, there was no difference in age, self-identified race/ethnicity, or the evaluated obstetric factors between the groups. Bleeding was present after clamp removal in 3 (6.3%) insertions using an Allis clamp and 26 (55.3%) insertions using a single-tooth tenaculum (RR = 0.113, CI=[0.037, 0.3481], p < 0.0001). There was no difference in IUD insertion success rates between the two clamps. There was no difference in the number of interventions required for hemostasis when bleeding occurred after clamp removal. Pain scores did not differ based on clamp type or age of patient, but were significantly different based on parity (p < 0.001) and IUD type (p < 0.003).CONCLUSIONThe Allis clamp should be used instead of a single-tooth tenaculum for cervical stabilization because of decreased incidence of clamp site bleeding with unchanged insertion success.The trial was retrospectively registered on 1/11/22 (trial registration number NCT05187078).
Intelligent Security Gate
Authors: Elwan Mohammed , Salem Amira , Fawky Hossam , Mahmoud Ahmed
Published: March 2022

Modern organizations have to use digital technology and digital transformation is the way to achieve this. Track employee attendance digitally and do not rely on outdated bookkeeping methods to improve the time spent during working hours, calculate annual leave for employees, and efficiently process payroll. In this research paper, a gate has been proposed through which employees' departure and attendance are calculated. And prevent any unwanted person from entering and at the same time, a unit can be added through which individuals are sterilized to the Prevention of the coronavirus. The proposed system showed high efficiency in recording the attendance and the departure of employees, as well as preventing any unwanted person from entering. The raspberry pi 4 model/ 8GB is used and the practical tests were conducted and applied to the system of employees of the Egyptian Academy of Engineering and Advanced Technology
Designing and Modelling of Trivalent Chimeric Vaccine for Capripoxvirus: Lumpy Skin Disease, Sheep Pox and Goat Pox by Immunoinformatics Approach
Authors: M Pashupathi , S Anbazhagan , N Barkathullah , Priyadarsini Swagatika , Panda Snehasmita , C Nikhil K. , Kumar Ajay
Published: March 2022

Capripoxvirus belongs to poxviridae family and causes three economically important diseases in ruminants namely, lumpy skin disease (LSD) in cattle, sheeppox in sheep, and goatpox in goats. Albeit non-zoonotic in nature, they have potential to cause high economic loss among the farmers. Capripoxvirus members share common structural proteins and can rise cross-immunity among them. The present study aimed to design a recombinant chimeric-vaccine from immunogenic proteins of these three members to protect all the host species by using immunoinformatics analysis. The palmitoylated EEV (Extracellular Enveloped Virion) membrane glycoprotein of LSD virus, SPPV-ORF 117 of sheeppox virus, B5R (EEV host range protein) of goatpox virus, and a common protein to all the members, P32, were the major immunodominant proteins used in the present chimeric vaccine construction. Several computational tools were applied to define the most immunogenic regions and different possible adjuvants and universal T-helper agonists were linked to the new construct. The designed vaccine construct was examined for physicochemical properties, immunogenicity, 3D model, Docking analysis and Molecular Dynamics simulations, by using reliable software. After evaluation of the results, the final designed vaccine is expected to have potential in stimulating the humoral response in addition to the cellular responses with acceptable stability.
Sheet Metal Blanking Modeling Using Lode-Dependent Plasticity and Ductile Damage Models Combined with 3D Adaptive Remeshing Method
Authors: cherouat abel , Zhang Jie , Borouchaki Houman
Published: March 2022

This paper is devoted to numerically study the sheet metal blanking process using elastic-visco-plastic model fully coupled with ductile damage and 3D adaptive remeshing procedure. The proposed constitutive theory aims to capture the effects of irreversible damage associated with the failure mechanisms that occur in sheet metal forming under large deformation. The isotropic ductile damage fully coupled into an elasto-viscoplastic flow stress model and stress state parameters (stress triaxiality and Lode angle) are proposed to control the damage evolution under multi-axial loading path. When a sheet metal is sheared by large elastic-viscoplastic strains, the propagation of macroscopic cracks induces severe changes of topology and frequent remeshing must be performed in order to avoid large mesh distortion and element quality. An h-adaptive Constraint Delaunay kernel remeshing scheme (refinement and coarsening) dedicated to the simulation of macroscopic ductile cracks initiation and propagation during blanking processes is proposed. Cracks are represented using a procedure based on fully damaged elements deletion. Optimal adaptive element size is driven by error indicators based on both geometrical considerations (tool geometry, deformed part) and the derivatives of physical field (plastic strain or damage localization). The proposed methodology was successfully verified comparing the predicted evolution of material ductility with the experimental data relative to several metals. The procedure for the blanking simulation is also discussed in details.
Analysis of the use of [68Ga]Ga-FAPI and [18F]FDG PET/CT for diagnosing and staging non-small cell lung cancer
Authors: Wu Junhao , Deng Hao , Zhong Haoshu , Wang Tao , Zheng Kai , Rao Zijuan , Gong Weidong , Wang Yingwei , Chen Yue , zhang chunyin
Published: March 2022

Purpose
The current research was developed for comparing the relative diagnostic utility of [68Ga]Ga-FAPI PET/CT and [18F]FDG PET/CT when evaluating initial tumors and metastases in non-small cell lung cancer (NSCLC) patients.
Methods
A prospective analysis of 28 individuals with histopathologically confirmed NSCLC that underwent [68Ga]Ga-FAPI and [18F]FDG PET/CT imaging was conducted. The relative performance of these different imaging modalities was compared based upon visual assessment, rates of cancer detection, and metabolic parameters (target-to-background ratio [TBR], maximum standard uptake value [SUVmax]) for both primary tumors and metastases.
Results
In total, this study enrolled 28 cases (13 male, 15 female; median age: 60.5 years, range: 34–78 years. [68Ga]Ga-FAPI PET/CT imaging was found to more effectively discern both metastases and primary tumors as compared to [18F]FDG PET/CT imaging, detecting more primary tumors (28 vs. 27), as well as metastases present within the lymph nodes (53 vs. 49), pleura (8 vs. 7), liver (4 vs. 1), and bone (41 vs. 35). In contrast, [68Ga]Ga-FAPI PET/CT was not capable of detecting as many adrenal metastases as was [18F]FDG PET/CT imaging (0 vs. 2). The SUVmax and TBR values for [68Ga]Ga-FAPI were substantially superior to those for [18F]FDG in lymph node, pleural, and bone metastases. While the SUVmax for these two imaging approaches was comparable for hepatic metastases, [68Ga]Ga-FAPI exhibited a significantly higher TBR in relation to that of [18F]FDG. [68Ga]Ga-FAPI additionally exhibited greater accuracy than that achieved for [18F]FDG PET/CT when used to conduct NSCLC patient N-staging (80% [8/10] vs. 50% [5/10]) and M-staging (92.9% [26/28] vs. 89.3% [25/28]).
Conclusions
These data highlight the value of [68Ga]Ga-FAPI PET/CT imaging as an approach of diagnosing and staging NSCLC, improving the diagnosis of most metastases and facilitating the superior staging of NSCLC patients relative to that achieved by [18F]FDG PET/CT.
Optimization of Dilute Acid Pretreatment for Enhanced Release of Fermentable Sugars from Sugarcane Bagasse and Validation by Biophysical Characterization
Authors: Hans Meenu , Pellegrini Vanessa O.A. , Filgueiras Jefferson G. , de Azevedo Eduardo R. , Guimaraes Francisco E.C. , Chandel Anuj Kumar , Polikarpov Igor , Chadha Bhupinder Singh , Kumar Sachin
Published: March 2022

Pretreatment of biomass is one of the most challenging steps in process of second generation (2G) ethanol and biochemicals production. Dilute acid pretreatment is a widely adapted and convenient method to recover pentose (C5) as well as hexose (C6) sugars due to its featured solubilization of hemicellulose and cellulose before and after enzymatic saccharification, respectively. In the present study, dilute sulphuric acid (H2SO4) pretreatment of sugarcane bagasse (SCB) was statistically optimized using factorial central composite design (FCCD) of response surface methodology (RSM) in terms of acid concentration (0.1-3% v/v), solid loading (5–20% w/v) and retention time (15–30 min) at constant temperature of 121 oC followed by enzymatic hydrolysis using commercial cellulase (Novozymes Cellic CTec2) for enhanced combined sugar yield (CSY) together with C5 and C6 in pretreated as well as saccharified hydrolysates. Optimized process parameters found in the study were 2.18% (v/v) acid; 14.35% (w/v) solid loading; 29.49 min retention time. CSY under optimized conditions was found to be 521.42 ± 7.2 g/kg raw SCB with 72.06 ± 1.0% sugars recovered out of maximum theoretical sugars present in raw biomass. Total reducing sugars yields in pretreated and saccharified hydrolysates were found to be 215.28 ± 2.4 and 306.14 ± 5.3 g/kg raw SCB, respectively. Morphological and structural changes in optimized pretreated and saccharified biomass further validated the efficiency of optimized pretreatment applied in the present study. The maximum ethanol concentration, volumetric productivity, and yield from released sugars were calculated as 10.82 ± 2.2 g/l, 0.45 ± 0.9 g/l/h and 0.42 g/g-glucose consumed or 71.45 ± 2.5 g/kg raw SCB, respectively. Ethanol yields obtained from fermentation of dilute H2SO4 pretreated SCB was corresponding to 82.4% of the maximum theoretical yield (0.51 g/g).
Prediction of the therapeutic efficacy of epirubicin combined with ifosfamide in patients with lung metastases from soft tissue sarcoma based on chest enhanced CT radiomics features: a pilot study
Authors: Miao Lei , Ma Shu-Tao , Jiang Xu , Zhang Huan-Huan , Wang Yan-Mei , Li Meng
Published: March 2022

Objective
To investigate the value of enhanced chest CT radiomics features in predicting the efficacy of epirubicin combined with ifosfamide in patients with pulmonary metastases from soft tissue sarcoma
Methods
In a retrospective analysis of 51 patients with pulmonary metastases from soft tissue sarcoma, all received the chemotherapy regimen of epirubicin combined with ifosfamide, and the efficacy was evaluated by the RECIST(1.1). Each patient selected 1 or 2 chemotherapy regimens. Lung metastases were used as target lesions (86 target lesions total), and the patients were divided into a progression group (n = 29) and a nonprogressive group (n = 57). The nonprogressive group included a stable group (n = 34) and a partial response group (n = 23). Information of lung metastases was extracted from enhanced CT images before chemotherapy, and all lesions were delineated by ITK-SNAP software manually or semiautomatically. The decision tree classifier had a better effect in all radiomics models. The receiver operating characteristic (ROC) curve was plotted to evaluate the predictive performance of the model for progression vs. nonprogression.
Results
In total, 851 enhanced CT radiomics features were extracted for each target lesion and finally reduced to 2 radiomics features, which were used to construct a radiomics model. The areas under the curve (AUCs) of the model for predicting the progression of lesions were 0.917 and 0.856 in the training and test groups.
Conclusion
The model established based on the radiomic features of chest enhanced CT before treatment has certain predictive value for the chemotherapy efficacy of patients with soft tissue sarcoma lung metastases.
Accuracy of Neck Circumference as a Screening Test for Cardiovascular Disease Risk.
Authors: Ssebuliba Moses Kiwanuka , Ssinabulya Isaac , Nanvuma Aidah , J Reynolds Steven , Mulumba Yusuf , Kizza Harriet Mayanja- , Miriam Laker , Barbara Castelnuovo
Published: March 2022

BackgroundThe risk of cardiovascular disease (CVD) among people living with HIV (PLWH) is 2.0 times higher than in the general population. Neck circumference (NC) is a simple and inexpensive measurement and correlates well with the CVD risk in studies done outside sub-Saharan Africa. We determined the accuracy of neck circumference and the NC cut-off indicative of increased CVD risk in PLWH. MethodologyIn this cross-sectional study, we enrolled PLWHIV ≥ 30 years from urban clinics in Uganda in 2019. Medical history, physical examination (including NC), lipid profile, and HbA1C were obtained. CVD risk was computed using the Framingham Risk Score (FRS). Receiver operator curves (ROC) were constructed for different values of NC with FRS as the gold standard, whence to determine the accuracy of NC as a screening tool and the cut-off indicative of CVD risk. Factors associated with increased NC above the cutoff were determined using the Poisson regression modelResultsOf the 384 enrolled participants, 74% were females, the median age was 42 years (IQR 34-39 years) and median NC 33 cm (IQR 31-35 cm), meantime from HIV diagnosis 8.9 years. The area under the ROC was 0.63 and the optimum NC cut-off was 35 cm (sensitivity 43.9%, specificity 75.1%). Factors associated with a neck circumference ≥ 35 cm were male gender (Adjusted Poisson ratio (APR): 2.7, CI: 2.15 - 3.4; P<0.001), increased body mass index (overweight APR 2.4, CI: 1.24 - 4.47, P:0.009; obese APR: 3.2, CI: 1.67 - 6.24, P < 0.001), waist circumference, (1.7, CI: 1.26 - 2.21<0.001). Having HDL ≥ 1.50 was found to be negatively associated with large NC (0.7, CI: 0.55 – CI: 0.87 P: 0.002)ConclusionNC measurement is an easy tool that can be used accurately at cut off values of 35 cm to screen HIV individuals for risk of CVD
Fabricated HMNPs with Size Approaching ~100 nm for MMC Loading and Sustained-release, as well as Labeling 99Tcm
Authors: Yang Yuxiang , Chang Ziling , Dong Mengyang , Li Huafei , Ni Chaoying , Yuan Hongming
Published: March 2022

Herein, we developed the dual-function template method to fabricate hollow magnetic nano-spheres (denoted as HMNPs-Cn, n = 16, 18) with a mesoporous shell and hollow interior structure using alkyl chain trimethoxysilane templating. The microstructure of the HMNPs-Cn was investigated by means of XRD, FT-IR, EDS, SEM, TEM and N2-BET analyses. The shorter chain template directed formation of HMNPs-C16 with size of 119 nm, having disordered inkbottle type mesopores and saturation magnetization of 50.01 emu/g. It can be observed that, mitomycin C (MMC) loaded HMNPs-Cn hollow spheres showed a clear pH-dependent drug release behavior, having a higher release rate in acidic environments of pH 5.7. For the pH 5.7 and 7.4 release, the diffusion through HMNPs-Cn hollow spheres is the rate limiting step, the release kinetic for HMNPs-C16-MMC composites follows pseudo-first-order attributable to its special pore structure. For this reason the inner cavity of HMNPs-C16 could be labeled with radioisotope 99Tcm to study the magnetic targeting distribution of HMNPs-C16 in vivo, and its cytotoxicity against in vitro HeLa cells was also studied. These results indicate the potential of HMNPs-C16 in the magnetic targeted drug delivery system.