bluuebunny/crossref_metadata_2025 huggingface dataset:
Рroblems of PCR diagnostics OF COVID-19
Authors: Grigorieva T. D. , Belopolskaya M. А.
Published: October 2022

To date, an adequate and timely assessment of the number of cases is the basis of effective measures aimed at preventing the spread of COVID-19 infection. Real-time reverse transcription polymerase chain reaction (RT-PCR) remains the gold standard for confirming COVID-19.

The purpose of the work: to analyze the experience of the city virological center of the S.P. Botkin Clinical Infectious Diseases Hospital (Botkin Hospital) for the examination for the presence of SARS-CoV-2 coronavirus by PCR in the period from 2020 to 2022.

Materials and methods. The systematization of PCR studies on COVID-19 for the period 2020-2022 was carried out. A total of 221,901 people were examined, positive results were obtained in 55,372 (24.95%). Among the contingents of the examined patients, patients who underwent inpatient treatment at the Botkin Hospital.

Conclusions. This study analyzed the possible causes of false-positive and false-negative PCR results. The correlation of the number of positive results with the dynamics of detection of new cases of COVID-19 in St. Petersburg during the 2020-2022 pandemic is shown. It has been established that the proportion of patients examined more than 3 times during the period of hospitalization remains significant. This fact requires the closest attention, given the high cost and laboriousness of PCR studies.
Clinical Infectious Diseases Hospital named after S.P. Botkin: 140 years of service to people
Authors: Kotlyarova S. I.
Published: October 2022

In 2022, the Clinical Infectious Diseases Hospital named after S.P. Botkina (Botkin Hospital) celebrated its 140th anniversary. The name of this famous medical institution is associated with the history of domestic infectology, the history of the fight against infectious diseases, including the development of disinfection in Russia. The review presents historical data on the activities of the Botkin Hospital in different eras of our country. Particular attention is paid to scientific developments introduced into the practice of the institution.
Children’s perception of the visual identity of Belgrade
Authors: Bogdanovic Bojana
Published: October 2022

The focus of this paper is a research field that has (until now) remained
outside the main academic theoretical frameworks - the question of the
visual identity of Belgrade seen (and experienced) from the perspective of
children. In methodological terms, the paper relies on the results of field
research conducted in March 2021 at the Kneginja Milica (Princess Milica)
Primary School in New Belgrade, which included a sample of 60 children from
Years 1 to 4. The aim of the paper is to discuss from an anthropological
perspective some of the key issues of perceiving the appearance of the
capital as a visual entity per se: 1) Which visual markers of Belgrade, in
the opinion of children, are key to its visual identity and what are the
central points on the symbolic map of the capital?; 2) What is the main
symbol of Belgrade and what criteria guide the participating children when
selecting this central visual marker?; 3) (To what extent) are individual
children?s perceptions of the panorama of the capital compatible with each
other and what are the characteristics of the general children?s image of
the capital?; 4) (In what way) Is the children?s image of the city in
harmony with the ?official? image of Belgrade? and 5) Is the child?s
perception of the visual identity of the capital the result of direct or
indirect urban experience?
Upper primary school children’s cosmogonic ideas: Childhood and space
Authors: Tomasevic Milan
Published: October 2022

This paper collates research on the ideas about the origin of the universe and the planet Earth that pupils from Years 5 to 8 of primary school in Belgrade have. Such knowledge should open space for us to further analyse the attitude of young people towards science and the world it describes. With them, it is possible to gain a better insight into the basic ideas about reality that people build and adopt in general. The starting hypothesis is that pupils themselves create hybrid concepts that combine knowledge from classes, ideas from popular culture, and modern scientific theories that are available to them through various media. The cosmological knowledge offered to pupils in geography classes will be analysed, along with the popular discourse accessible to young people. Finally, a preliminary ethnographic study of pupils? cosmogonic ideas conducted on a pilot sample will be presented. The aim of the research is to understand the pupils? fundamental knowledge about reality, about the formation of a cognitive framework in which pupils inscribe their own ideas about the place of the Earth and life in space.
1 Do you believe in Ram Setu? Adam’s Bridge, epistemic plurality and colonial legacy
Authors: Chatterjee Arup
Published: October 2022

The Sethusamudram Shipping Canal Project, whose construction was halted by a 2013 judgment of the Supreme Court of India due to religious sensitivity, has become a domestic and international strategic flashpoint. The religious and epistemic conundrum around the Sethusamudram project and Adam’s Bridge is a colonial-era legacy. Without understanding how the British colonial state saw Adam’s Bridge, we may wrongly infer that today’s Indian nationalist assertions of its sacrality necessarily stem from an anticolonial praxis to restore a politics of enchantment within Indian modernity. The British colonial state adopted epistemes or modes of knowing Adam’s Bridge that were ostensibly compatible with pre-Western forms of enchantment. This is particularly important considering that nationalist voices, largely represented by the right-wing BJP (Bharatiya Janata Party), RSS (Rashtriya Swayamsevak Sangh) and the Sangh Parivar in general, and liberal voices representing the Congress (Indian National Congress), or regional political voices such the DMK (Dravida Munnetra Kazhagam) and AIADMK (All Indian Anna Dravida Munnetra Kazhagam), have dated the origins of the proposed Sethusamudram project to the colonial era, erroneously prolonging the implication that the British government aided plans of demolishing Adam’s Bridge.
The Structure of Laughter in Shakespeare’s 1 Henry IV
Authors: Innes Paul
Published: October 2022

Shakespeare’s 1 Henry IV (c.1597) is the second play in a group of four that deals with the first two Lancastrian kings of England, Henry IV and his son Henry V. This loosely connected series is known as the Second Tetralogy because even though the events portrayed precede the four plays that deal with Henry VI and Richard III, Shakespeare wrote those set earlier in English history a little later in his career. The main aim of this study is to investigate the carnivalesque in 1 Henry IV, understood as a layer of unofficial or popular culture that plays against and undercuts or inverts the official world of the court, high politics, and chivalry. The significance of this study lies in its analysis of how this interaction structures the play; these are not just surface features. The main question is how the carnivalesque affects the level of high politics in the play. The context for the study derives from critical approaches to the play that have been influenced by critical theory, especially in the carnivalesque; the procedure is a detailed qualitative analysis using techniques of textual criticism. The main finding is that the play is not only structured along these lines but also that the level of high official culture is itself put in question by a full awareness of the historical events mentioned in the play.
Soueif’s Aisha: A Portrait of Memory, Time, and Liberation
Authors: Brahimi Samira
Published: October 2022

This paper explores The Returning, which is a short story written by Ahdaf Soueif. The Returning is selected from the author’s first collection of short stories entitled Aisha which was written in 1983. It is Soueif’s first fictional work. This paper focuses on the way the author depicts her female protagonist named, Aisha, as a nostalgic character. Aisha revisits her past and bumps into lost memories with her husband. Soueif also portrays Aisha’s transformation into a liberated and liberating female character. Aisha transcends time and the clutches of her past to claim a fresh start. This paper attempts to reveal how the author focuses on her protagonist’s memory and journey throughout her past, returning to the present. It also focuses on the author’s utilization of time-shift technique to depict her protagonist’s set-forth liberation and that of her story from oblivion and the chains of a lost past. This paper reveals an alternative vision of female characters detached from clichéd female portraits. It also unwinds creative images of time as flexible and co-existing entities; past, present, and future.
The Cultural and Semantic Problems Encountered in Translating the Arabic Qur’anic- Specific Lexica ”Alkyedالكَيْدُ” in Sūrat Yusuf into English
Authors: Albashir Mohammed Alhaj Ali
Published: October 2022

Translating the Arabic Qur’an-specific lexicon into English has always been an arduous and excellent complex task. It is increasingly problematic than the translation of the Qur’an-specific lexicon in other forms of general due to the specific contexts of the Glorious Qur’an and its unique rhetorical nature. The recent work predominantly peruses on the cultural and semantic problems met by translators in rendering the Arabic Qur’an-specific lexicon ‘Alkyedالكَيْدُ” in Sūrat Yusuf into English and examines their translation losses. The paramount significance of this research paper is how the intended translators tried to attain appropriate cultural equivalence when rendering connotative meaning and deeper meaning of Qur’anic-specific lexica ”Alkyedالكَيْدُ” in Sūrat Yusuf. Moreover, targeted three notable translations of the Qur’an-specific lexicon into English, namely, Pickthall’s (1996), Khan’s, Al Hilali’s (1996), and Abdul Haleem’s (2004) were chosen by the researcher to show their renderings of the implicative meaning of Arabic Qur’anic-specific lexica into English. Furthermore, the recent research paper purports to find out the proper rendition techniques and approaches maneuvered in rendering Qur’anic-specific lexica ”Alkyedالكَيْدُ” in Sūrat Yusuf into English. The study indicates that three targeted translators’ renderings found cultural and semantic problems translating Quranic-specific lexica into English. It is also discovered that apt lingual and interpretative analyses are prerogatives for appropriate translation, which avert divergence in connotative meaning and rendition loss. The study concludes that the three targeted translators employed culturally equivalent and neutral explanation procedures and word-for-word and sense-for-sense translation methods.
The Image of the Artist in Orhan Pamuk’s My Name is Red and Irving Stone’s The Agony and Ecstasy
Authors: Qahtan Sulaiman Maha
Published: October 2022

This paper examines the influence of Renaissance themes and techniques in art on miniaturist painting in Istanbul and on shaping Michelangelo’s attitude to sculptor and painting in Italy. The clash between Eastern and Western painting techniques is part of the conflict in Orhan Pamuk’s My Name is Red. The novel is set in sixteenth-century Istanbul and the main characters are miniaturists who inherited the Persian style of painting. Istanbul people were very religious and the Muslim miniaturists felt unconfident and constantly tortured about their paintings. Artists were considered trying to imitate God and create their own perception of the world. The miniaturists of the novel are commissioned to adopt Venetian art with its emphasis on lifelike painting and individuality. Consequently they suffer of whether their creative work is considered blasphemous, or not. My Name is Red is juxtaposed to Irving Stone’s biographical novel The Agony and the Ecstasy. The novel is set in approximately the same time that the events took place in My Name is Red. It concerns the life and work of the Renaissance Florentine painter and sculptor Michelangelo. The study examines the cultural atmosphere that determined Michelangelo’s approach to art. It also addresses how religion has been the main source of inspiration for Michelangelo’s themes, and consequently it was the medium through which he presented his own version of man. Both novels are examined according to the relation of Renaissance humanism to art and religion.
Quantum Molinism
Authors: Harvey Thomas , Kroon Frederick , Svozil Karl , Calude Cristian
Published: October 2022

In this paper we consider the possibility of a Quantum Molinism: such a view applies an analogue of the Molinistic account of free will‘s compatibility  with God’s foreknowledge to God’s knowledge of (supposedly) indeterministic events at a quantum level. We ask how (and why) a providential God could care for and know about a world with this kind of indeterminacy.  We consider various formulations of such a Quantum Molinism, and after rejecting a number of options arrive at one seemingly coherent formulation.
Reformulating Indifferentism
Authors: Greco Francesca
Published: October 2022

In his examination of the concepts of evil and impermanence, entitled “Evil and the Problem of Impermanence in Medieval Japanese Philosophy”, Yujin Nagasawa addresses four responses to the problem of impermanence, arguing that the only satisfactory response to the problem leads to an implication about supernaturalism. As Nagasawa puts it, “the problem of impermanence can be construed as a partial argument for supernaturalism and against naturalism”. In response to Nagasawa, I will take up the challenge of naturalism by trying to deconstruct the arguments against indifferentism in order to reformulate and thus strengthen Nagasawa’s response to the problem of impermanence. I will then turn to the radicalization of this thesis by drawing out implications through a comparison with Dōgen’s thought.
Reply to Oliver Wiertz, Masahiro Morioka and Francesca Greco
Authors: Nagasawa Yujin
Published: October 2022

Oliver Wiertz, Masahiro Morioka and Francesca Greco have responded to my paper, ‘Evil and the Problem of Impermanence in Medieval Japanese Philosophy’. Here, I reply to each of them individually, focusing on specific points raised in critically addressing my approach to the problem of impermanence.
Towards a Global Philosophy of Religion
Authors: Cordeiro-Rodrigues Luis
Published: October 2022

This piece replies to a recently published article in the European Journal for Philosophy of Religion by J. L. Schellenberg and Paul Draper. They contend that the field of African philosophy of religion needs renewal, and they make several recommendations on how to achieve this. I agree with their recommendations, but I argue they have omitted a crucial problem and solution to renew the field; namely, a fundamental problem of the field is that it systemically excludes non-Western philosophies and scholars and, therefore, the field needs to be decolonised.
PERAN GURU PENDIDIKAN PANCASILA DAN KEWARGANEGARAAN DALAM PENGUATAN PROFIL PELAJAR PANCASILA DI SEKOLAH
Authors: Rudiawan Rofi , Asmaroini Ambiro Puji
Published: October 2022

Profil Pelajar Pancasila adalah program yang dibuat Kemendikbud sebagai upaya memperkuat pendidikan karakter di Indonesia. Program ini dapat menjadi jalan untuk mewujudkan tujuan pendidikan nasional yakni membentuk generasi yang cerdas secara intelektual dan memiliki karakter yang sesuai dengan pancasila. Dalam proses penguatan Profil Pelajara Pancasila penting adanya peran dari seorang guru  utamanya guru PPKn. Tujuan dari penelitian ini adalah untuk mengetahui peran guru PPKn dalam penguatan Profil Pelajar Pancasila. Penelitian ini menggunkan metode penelitian literatur review. Isi dan pembahasan dalam penelitia ini terkait peran guru PPKn dalam penguatan profil pelajar Pancasila di sekolah.. Dari hasil kajian yang dilakukan peran guru PPKn sangatlah penting karena guru PPKn bukan hanya sekedar mentransfer ilmu  pengetahuan tapi juga motivasi dan karakter pada anak. Dalam upaya penguatan Profil Pelajar Pancasila guru harus memiliki kemampuan utama yaitu sebagai contoh/ tauladan bagi anak.  Memiliki perencanaan pembelajaran yang fokus pada pembentukan nilai-nilai Pancasila. Membuat pembelajaran yang berbasis pendekatan kearifan lokal. Membangun kesadaran peserta didik melalui model pembelajaran berbasis proyek. membuat pembelajara yang menarik dan tidak terbatas pada ruang, tempat dan waktu. Model pembelajaran yang memanfaatkan perkembangan TI. Membuat evaluasi pembelajaran yang terpusat pada pendekatan saintifik.
PENGEMBANGAN LEMBAR KERJA PESERTA DIDIK BERBASIS PROYEK PADA TEMA INDAHNYA KERAGAMAN DI NEGERIKU
Authors: Dinasti Dara , Sukmawarti Sukmawarti
Published: October 2022

Penelitian ini bertujuan untuk: (1) menghasilkan lembar kerja peserta didik berbasis proyek pada tema indahnya keragaman di negeriku, (2) mengetahui kelayakan media pembelajaran yaitu lembar kerja peserta didik berbasis proyek pada tema indahnya keragaman di negeriku yang valid dari hasil validasi kelayakan oleh ahli materi, ahli media dan angket respon guru dan peserta didik. Penelitian dilakukan di UPT SD NEGERI 105292 Bandar Klippah dengan menggunakan objek 30 siswa/i kelas IV SD untuk menguji cobakan LKPD berbasis proyek pada tema indahnya keragaman di negeriku. Instrumen yang digunakan untuk mengumpulkan data adalah angket dan tes LKPD berbabasis proyek. Teknik analisis data yang digunakan adalah teknik analisis metode campuran yaitu kualitatif dan kuantitatif. Hasil penelitian menunjukkan Pengembangan Lembar Kerja Peserta Didik Berbasis Proyek dilakukan dengan melakukan prosedur pengembangan model ADDIE (Analysis, Design, Development, Implementation,and Evaluation). Berdasarkan hasil penilaian yang di validasi oleh ahli materi dan media bahwa LKPD berbasis proyek yang dikembangkan sangat valid atau dapat digunakan tanpa revisi untuk siswa kelas IV SD. Dari hasil angket kepraktisan guru dan peserta didik dikatakan cukup praktis, atau dapat digunakan namun perlu revisi kecil. Dan dari hasil uji coba keefektifan peserta didik banyaknya peserta didik mencapai ketuntasan minimal (KKM) 27 orang dengan 3 siswa yang tidak mencapai ketuntasan minimal (KKM) dengan jumlah 30 orang siswa. Berdasarkan hasil hitungan dari uji-coba keefektifan peserta didik dilihat dari analisis data maka mendaptkan hasil 90 dan dilihat dari tabel kriteria keefektifan setara 81% - 100% dikatakan sangat efektif atau dapat digunakan tanpa revisi.  Kata Kunci : Project Based Learning, LKPD Berbasis Proyek, Pembelajaran Tematik
PELAKSANAAN PENGELOLAAN KELAS DALAM RANGKA PENINGKATAN EFEKTIVITAS PEMBELAJARAN ONLINE DI SMP PGRI PANGKALAN
Authors: Faujiah Sifa , Wahyudin Undang Ruslan
Published: October 2022

Pelaksanaan pengelolaan kelas menjadi semakin penting bagi para guru di dunia pendidikan, terutama di masa pandemic ini para guru harus mempersiapkan pelaksanaan pengelolaan kelas secara online. Walau demikian pelaksanaan pengelolaan kelas tersebut tidak akan begitu kondusif seperti secara langsung, namun upaya tersebut untuk meningkatkan efektivitas belajar siswa sangat penting selama masa pandemic ini belum selesai. Pembelajaran secara online di SMP PGRI Pangkalan ini memiliki tujuan untuk menciptakan dan memelihara lingkungan belajar yang positif. Penelitian ini akan melihat fungsi guru dalam pelaksanaan pengelolaan kelas untuk meningkatkan mutu pembelajaran online di SMP PGRI Pangkalan. Metode yang digunakan dalam penelitian ini yaitu metode deskriptif kualitatif, pengumpulan data dilakukan dengan observasi, wawancara dan dokumentasi. Pengumpulan data, reduksi data, dan penyajian data merupakan strategi analisis data yang digunakan dalam penelitian ini. Hasil pada penelitian ini adalah 1) pelaksanaan pengelolaan kelas yang efektif dalam meningkatkan efektivitas pembelajaran online. sesuai dengan temuan penelitian ini. 2) pelaksanaan pengelolaan kelas menitikberatkan pada perencanaan, penggerakan, dan pengendalian untuk meningkatkan mutu pembelajaran siswa secara online. 3) guru menggunakan media online seperti Google meeting, zoom, dan classroom dalam pelaksanaan pengelolaan kelas sebagai standar evaluasi pembelajaran untuk melacak proses, kemajuan, dan perkembangan hasil belajar siswa.
PENGUATAN NILAI-NILAI PANCASILA DI TK AISYIYAH KENITEN
Authors: Rofidah Nabila Faizatur , Wulansari Betty Yulia , Cahyono Hadi
Published: October 2022

Tujuan dalam penelitian ini adalah untuk: (1) Menetapkan proses pelaksanaan penguatan nilai-nilai Pancasila tentang kemanusiaan yang adil dan beradab di TK Aisyiyah Keniten. (2) menemukan nilai dalam proses penerapan sila-sila Pancasila tentang kemanusiaan yang adil dan beradab di TK Aisiyah Keniten; (3) Menemukan faktor pendukung dan penghambat yang dihadapi dalam proses pelaksanaan penguatan nilai-nilai Pancasila, prinsip-prinsip kemanusiaan yang adil dan beradab, TK Aisyiyah Keniten.Ini adalah survei kualitatif yang ditargetkan. Teknik pengumpulan data melalui pengamatan dan wawancara dengan kepala sekolah, guru dan siswa TK Aisyiyah Keniten. Kegiatan penelitian untuk mengumpulkan data lapangan dari sumber data. Teknik wawancara dan pengamatan digunakan sebagai teknik pengumpulan data dalam penelitian ini. Kemudian, rangkum data dengan memilih yang paling penting dan fokus pada yang penting sesuai dengan topik penelitian Anda. Langkah selanjutnya adalah menampilkan data. Penyajian data penelitian ini adalah teks naratif. Langkah terakhir dalam menganalisis penelitian kualitatif adalah menarik kesimpulan. Hasil penelitian ini dalam proses penguatan nilai-nilai Pancasila, prinsip-prinsip kemanusiaan yang adil dan beradab di TK Aisiyah Keniten, menunjukkan perilaku yang mencerminkan prinsip-prinsip kemanusiaan yang adil dan beradab pada siswa sawah. TK Aisiyah Keniten layak diikutsertakan dalam proses penguatan nilai-nilai kemanusiaan yang adil dan beradab. Ada pula faktor pendukung dan penghambat dalam proses penguatan nilai-nilai Pancasila, sila kemanusiaan yang adil dan beradab
EXPLORING A DIGITAL TOOL “NEARPOD” TO IMPROVE STUDENTS’ SKILL IN WRITING
Authors: Lestari Puji , Sihombing Lambok Hermanto
Published: October 2022

Teachers with new and innovative methods will make teaching more engaging. The students will not get bored easily as they get enjoyable atmosphere. In this study, the researchers aim to elaborate the use of Nearpod as a digital tool to improve students’ skills. There are lots of skills that students can enhance through Nearpod. However, in this study, the researchers focus on how Nearpod can be utilized as a digital platform to improve their writing skill. To support this analysis, the researchers applied a qualitative methodology and used the Teaching by Principle theory by H. Douglas Brown and Heekyong Lee. The data was taken from official website of Nearpod, www.nearpod.com and some supporting articles. The result showed that Nearpod could be used as one of effective digital tools to enhance students’ skill in writing.
EFEKTIFITAS TEKNIK PENGAJARAN LISTENING SECARA ONLINE
Authors: G Hasriani , Risan Rahmad
Published: October 2022

Teaching English cannot be separated from teaching language skills, including Listening. This study aims to find out the views of students regarding the effectiveness of online learning technique applied by lecturer in teaching listening course. This research is a qualitative descriptive study. Data was collected through a questionnaire. The data collected were analyzed qualitatively by describing the information obtained through a questionnaire. The subjects of this study were 4th semester students of the English Education study program, Faculty of Languages and Literature, Universitas Negeri Makassar who had programmed the Intensive Listening course. The results showed that based on the results of the questionnaire, about 67% of students considered that online listening teaching was quite effective because the methods and materials presented by the lecturers were well received by them so that their listening skills improved. 10% of students think that they have problems in learning listening online because of internet network disturbances and limited internet quota. In addition, there are also difficulties with vocabulary. However, about 10% of students think that teaching listening offline or face-to-face is more effective than teaching listening online. They prefer to interact directly with lecturers. Around 13% of students think that teaching listening both offline and online is the same. It can be concluded that online listening teaching is effective in improving students' knowledge and skills as long as it is supported by methods, materials and devices that are in accordance with learning objectives.
Effectiveness of Using Wayang Beber Kreasi on Children's Storytelling Ability
Authors: Arwani Misbah , Wulandari Rifa Suci , Anwar Saiful
Published: October 2022

This study was conducted to determine the effectiveness of the use of wayang beber creative media on the storytelling abilities of group B PAUD Merak Ponorogo students in 2020. The research design used is experimental research in the form of Quasi Experimental Design. Data collection techniques used in this study are observation and documentation. The research instrument used was observation and documentation guidelines. To test the research hypothesis, the data analysis technique used is t-test. Prior to the t-test, the prerequisite tests were tests for normality and homogeneity. Based on the data analysis test carried out with the help of SPSS 18, it showed a significance value (2-tailed) for the Equal Variances Assumed column of 0.001 0.05, then H0 was rejected and Ha was accepted. The results of testing the data indicate that the use of wayang beber creative media is effective on children's storytelling abilities.
Development of Children's Creativity Through Traditional Games Ba-a-anakan and Ba-ka-kapalan
Authors: Khalidah Ratu Noor
Published: October 2022

From the purpose of this study, it can be seen about early childhood in developing creativity using traditional games ba-a-anakan and ba-ka-kapalan Creativity is a topic that has wide appeal, even creativity is often discussed in fields, one of which is education. This type of research is library research, sources of journals, books, documentation, internet and theoretical libraries that are the object of the research, namely the development of creativity through traditional games for young children. After the data is collected through data collection techniques, the next step is to analyze the data. The results of this research with literature study that children's creativity can develop through traditional games. In the traditional game of ba-a-anakan creativity will be honed because it invites children to imagine playing their role as a mother who has children and the traditional game of ba-ka-kapalan in playing micro roles, requires imagination from children to develop conversation. Imagination will affect creativity and artistic value in children. so that the role of the family environment and the school environment is very much needed to develop children's creativity through traditional ba-a-anakan and ba-ka-kapalan games.
Bioinformatic Characterization of a Kappa-Carrageenase from Pseudomonas fluorescens
Authors: Bakli Mahfoud , Bouras Noureddine , Paşcalău Raul , Șmuleac Laura
Published: October 2022

Kappa-carrageenase (EC 3.2.1.83) is a glycoside hydrolase family 16 (GH16) member that could specifically hydrolyse kappa-carrageenans to kappa-carrageenan oligosaccharides. Kappa-carrageenase enzymes have attracted much interest due to their numerous potential applications in biomedical and physiological fields, bioethanol production, and textile industry. In the present study, physicochemical, secondary structure, structural properties including homology modeling, refinement, and model quality validation, and functional analyses of the kappacarrageenanse from Pseudomonas fluorescens using various bioinformatic tools were conducted. The protein was found to be stable and acidic in nature. Secondary structure prediction revealed that the presence of random coil is more dominated in the protein sequence followed by extended strand, α-helix, and β-turn. Protein-protein interaction prediction revealed ten potential functional partners. This bioinformatic characterization provides for the first time insights into fundamental characteristics of the predicted Kappa-carrageenase of P. fluorescens, which may be useful for elucidating its applications and for further expression and characterization studies.
Evaluation of the Groundwater Quality in Amizour Plain (North Algeria) Through the Application of Heavy Metal Pollution Index
Authors: Saadali Riad , Dadach Mohammed , Bouguettaya Sarah , Benjeddi Sabrina
Published: October 2022

The concentrations of Three metallic elements, cadmium (Cd), lead (Pb), and zinc (Zn), have been evaluated in thirteen groundwater sampling points (from open wells) located near industrial, domestic and agricultural dumps of the Amizour plain (North Algeria). The contamination factor (Fc), the contamination degree (Dc), and heavy metal pollution index (HPI) were the models evaluated in aim to estimate the groundwater quality and the potential sources of trace metallic-elements infection. The concentrations of both Cd and Pb have been found to be below the permissible referred limits of drinking water quality standards, while Zn concentration exceeded the standards in most of the sampling points (eleven wells have Zn level > 15 ppb). The HPI of groundwater has been found to be far below the permissible limit of 100 (HPI = 40.6). Our obtained results give the assumption that the contamination of the studied groundwater is with limited extent, despite the prolific use of fertilizers and the intensive spill of industrial and domestic wastes in the ecosystem. Therefore, the low HPI values, noticed in the study zone, are likely attributed to the impermeability of geological formation preventing thus contaminants reaching the aquifer.
PENGARUH PERSEPSI KEBERMANFAATAN, KEMUDAHAN, DAN RISIKO TERHADAP MINAT PENGGUNAAN LAYANAN PEMBAYARAN DIGITRAL PADA MAHASISWA AKUNTANSI
Authors: Nenandha Nesha
Published: October 2022

People in Indonesia are starting to get used to using a digital payment system that can be done anywhere and anytime during transaction activities. Therefore, the researcher conducted a study entitled: "The Influence of Perceived Usefulness, Perceived ease of use, and Perceived Risk in Using Digital Payment Services in Accounting Students." The purpose of this study is to examine the factors that influence the interest in using digital payment services. The method used is a quantitative approach with a sample of 95 accounting students at Trisakti University as users of digital payments. The data analysis method used in this study used descriptive analysis, validity, reliability, normality, multicollinearity, autocorrelation, multiple linear, f-test, and coefficient determination tests. The result of the research is that the perception of usefulness and the perception of convenience have a positive and significant effect on interest in use, while the perception of risk has a negative effect on interest in use.
Orientação sexual e identidade de gênero: a homossexualidade e seus reflexos na saúde mental de estudantes de medicina de uma universidade sergipana
Authors: Ferreira Danilo Bastos Bispo , Ferreira Fernanda Bastos Bispo , Menezes Camila Costa Santos , Souza Neta Adozina Marques de , Pessôa Bianca de Souza Leite , Mattos Roberta Machado Pimentel Rebello , Pimentel Déborah
Published: October 2022

Introdução: Por orientação sexual depreende-se como padrão de excitação física e emocional de um indivíduo, incluindo fantasias, comportamentos e atividades, e o(s) gênero(s) a quem um indivíduo é física ou sexualmente atraído. Lésbicas, gays, bissexuais e transgêneros (sigla LGBT) fazem parte de uma minoria que sofre muito preconceito e está sob constante estigma, logo, estão envoltos em diversos estressores Objetivo: Estimar a prevalência da população de lésbicas, gays, bissexuais e transexuais (LGBT) no curso de medicina de uma universidade sergipana; identificar possível desconforto quanto à orientação sexual no corpo discente; descobrir indícios de depressão nos participantes da pesquisa segundo a sua orientação sexual; determinar a relação entre desconforto e o relacionamento social acadêmico. Método: Amostra do tipo conveniência com 142 acadêmicos que assinaram o Termo de Consentimento Livre e Esclarecido e responderam quatro questionários: demográfico, Inventário de Depressão de Beck, Escala de Avaliação do Ambiente Acadêmico Frente às Necessidades da População LGBT e a Escala de Percepção de Suporte Social. Resultados: A minoria LGBT apresentou níveis maiores de aceitação e de percepção de suporte social, porém, quanto ao conhecimento de políticas públicas específicas para eles na academia, ambos os grupos demonstraram desconhecimento sobre o tema. Conclusão: Importante discutir sobre questões de gênero e saúde mental, tendo como finalidade buscar suporte psicológico e social aos que estão sofrendo.
potencial das tecnologias de informação e comunicação como ferramentas de psicoeducação na era das fake news
Authors: Oliveira Gustavo Rodrigues , Gomes Carla Ferreira , Machado Fernanda Morandi Riegel , Scherer Juliana
Published: October 2022

O combate a disseminação de notícias falsas e a desinformação em saúde tem sido apontado como um dos maiores desafios atuais dentro da saúde coletiva mundial. A psiquiatria e as áreas relacionadas à saúde mental são especialmente impactadas pela falta de educação em saúde, uma vez que estas ainda são fortemente relacionadas a estigmas e a marginalização social. Neste artigo, abordaremos as vantagens e as limitações do uso de tecnologias de informação e comunicação como ferramentas de psicoeducação, apontando futuros direcionamentos para o desenvolvimento dessas tecnologias.
Impact of disability in the quality of life of patients with traumatic brachial plexus injuries based on a questionnaire survey in a tertiary center in South India
Authors: Bhooshan Lekshmi S. , Gopal Vinu V. , Baburaj P. T.
Published: October 2022

Objectives:

The aim of the study was to assess the disability and its impact in the health-related quality of life (HRQOL) and its various domains in patients with traumatic brachial plexus injury (TBPI)

Materials and Methods:

A descriptive cross-sectional questionnaire survey was conducted on 41 patients with TBPI in a tertiary care center in South India. The assessment of disability and HRQOL was done as per the guidelines of the Gazette of India (2001) and WHO BREF questionnaire, respectively. The association between disability and HRQOL was determined using Chi-square test.

Results:

All patients were males in the age group 16–60 years (mean age 36.8 ± 14.4 years). Etiology was road traffic accident in 90.2% of cases. About 51.2% had pan-plexus injuries and 53.7% had their dominant limb affected. The mean total disability was 80.39 ± 13.86% and the mean total HRQOL score was 188.46 ± 83.44 out of 400. It was found that disability due to TBPI significantly reduced the HRQOL (Fisher’s exact P = 0.005) and the psychological domain was the most significantly affected (P = 0.017, Kruskal–Wallis test). Pan-plexus injuries with an involvement of dominant upper limb had significant impact in the HRQOL. Twenty-one patients (51.2%) complained of neuropathic pain and they had a significantly reduced quality of life (QOL) (mean QOL = 23.3, P < 0.001). It was also found that productive age group (26–55 years) had a significantly reduced QOL as compared to the extreme age groups (P = 0.000). Unemployed patients had a significantly reduced QOL as compared to those with permanent/temporary job (P = 0.024). Marital status was found to have no significant relationship with the total HRQOL (P = 0.647). Those belonging to the poor socioeconomic strata (below poverty line) had poor HRQOL as compared to those above poverty line and the relationship was found to be significant (P = 0.000).

Conclusion:

TBPIs significantly affected all domains of QOL, especially in unemployed patients in the productive age group in the poor socioeconomic strata. The pan-brachial plexus involvement of dominant upper limb and associated neuropathic pain were the most important factors which negatively affected the QOL. Among the codomains of the QOL, psychological domain was the most significantly affected irrespective of the severity of the injury.
Matrixmetalloproteinase-9 gene polymorphism (rs 17576) increases the risk of depressive symptoms in bipolar disorder
Authors: Saravanan Kothandan , Keshri Neha , Nandeesha Hanumanthappa , Menon Vikas , Goud Alladi Charanraj
Published: October 2022

Objectives:

Plasticity of neural synapses is known to be involved in the complications in bipolar disorder (BD) patients. Matrix metalloproteinases (MMPs) play a role in synaptic plasticity and memory. Even though elevated MMP-9 levels are reported in neuropsychiatric disorders, there is limited data about MMP-9 gene polymorphism in BD. The objectives of the study was to investigate genotype frequency and allele frequency of MMP-9 genetic variant (rs 17576) in BD and its association with disease severity.

Materials and Methods:

Eighty BD cases and 80 controls were recruited in the study. MMP-9 genotyping and allele frequency and plasma MMP-9 levels were analyzed in both the groups. Hamilton depression rating scale and Young’s Mania Rating Scale (YMRS) were used to evaluate severity of BD.

Results:

The genotype and minor allele (G allele) frequency were not significant between BD and controls. MMP-9 levels were significantly increased in BD patients with AG (P < 0.001) and GG (P = 0.022) genotypes compared to controls. BD patients with GG genotype (P = 0.038, OR: 3.26 (1.16–9.09), and G (mutant) allele (P = 0.013, OR 2.03(1.18–3.48) confer increased risk of depressive symptoms. MMP-9 was positively correlated with YMRS scale (r = 0.227, P = 0.043) in BD.

Conclusion:

MMP-9 gene polymorphism (rs 17576) is linked with depressive symptoms in BD.
Myocarditis-myositis-myasthenia gravis overlap syndrome depending on immune checkpoint inhibitor
Authors: Ünlütürk Zeynep , Karagülmez Ahmet Mağrur , Hayti Barış , Erdoğan Çağdaş
Published: October 2022

Immune checkpoint inhibitors are breakthrough monoclonal antibodies in cancer therapy developed against mechanisms that suppress the immune response. After the devastating effects of chemotherapy, these specific agents have given hope to cancer patients. However, every drug has side effects itself and these useful drugs have theirs too. In addition to systemic side effects, there are also neurological side effects, the frequency of which is increasing day by day, although they are reported very rarely for now. Here, we present a case that has myositis-myocarditis-myasthenia gravis overlap syndrome. These three syndromes are very rare even to be seen alone, which are detected together. This syndrome with a very high mortality was brought under control in this case, and the fact that nivolumab treatment can be continued makes the case even more interesting. In this article, it is aimed to draw attention to this serious triple complication of immune checkpoint inhibitors and to review the relevant literature on a case basis.
Associations of the neutrophil/lymphocyte ratio, monocyte/ lymphocyte ratio, and platelet/lymphocyte ratio with COVID-19 disease severity in patients with neurological symptoms: A cross-sectional monocentric study
Authors: Sahin Burc Esra , Celikbilek Asuman , Kocak Yusuf , Koysuren Aydan , Hizmali Lokman
Published: October 2022

Objectives:

Data are limited regarding the relationship of neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/ lymphocyte ratio (PLR) with neurological symptoms (NS) in COVID-19 patients. This study is the first to assess the utility of the NLR, MLR, and PLR for predicting COVID-19 severity in infected patients with NS.

Materials and Methods:

Consecutive 192 PCR-positive COVID-19 patients with NS were included in this cross-sectional and prospective study. The patients were classified into the non-severe and severe groups. We analyzed routinely complete blood count in these groups in terms of COVID-19 disease severity.

Results:

Advanced age, a higher body mass index, and comorbidities were significantly more common in the severe group (P < 0.001). Among the NS, anosmia (P = 0.001) and memory loss (P = 0.041) were significantly more common in the non-severe group. In the severe group, the lymphocytes and monocyte counts and the hemoglobin level were significantly lower, while the neutrophil count, NLR, and PLR were significantly higher (all P < 0.001). In the multivariate model, advanced age and a higher neutrophil count were independently associated with severe disease (both P < 0.001) but the NLR and PLR were not (both P > 0.05).

Conclusion:

We found positive associations of COVID-19 severity with the NLR and PLR in infected patients with NS. Further research is required to shed more light on the role of neurological involvement in disease prognosis and outcomes.
Major Perioperative Complications of Benign Gynecologic Procedures at a University-Affiliated Hospital
Authors: Busque Andrée-Anne , Belzile Eric , Rodrigues Julia , Larouche Maryse
Published: October 2022

Background: With the increasing use of minimally invasive techniques for gynecologic procedures, women are at a low risk for peri-operative complications. The purpose of this study was to determine the incidence of and risk factors for major intra or postoperative complications among women undergoing benign gynecologic surgeries.
Methods: We conducted a retrospective observational study of all women who underwent benign gynecologic surgery in 2016-2017 at a University-Affiliated community hospital. Pregnant women, malignancy cases, and hysteroscopic or minor vulvar procedures were excluded. Primary outcome was composite intraoperative and/or 30-day postoperative complications requiring medical or surgical management. Logistic regression identified significant patient, peri-operative and surgeon risk factors associated with complications.
Results: Of 975 patients included, 53 patients experienced major intra or postoperative complications (5.4%). Mean age was 47.7 ± 13.8 years. Mean BMI was 27.1 ± 5.8 kg/m2. Prior abdominal surgery (laparotomy or laparoscopy) (adjusted odds ratio [OR]= 2.01, 95%CI 1.05-3.83) and emergency surgery (adjusted OR= 19.54, 95%CI 2.99-127.54) were significantly associated with major complications. Surgeon volume of 1-2 operative days per month (adjusted OR=0.30, 95%CI 0.10 - 0.87) and age 40-64 years (adjusted OR=0.24, 95%CI 0.11- 0.56) had a protective effect on the risk of major complications.
Conclusions: Among patients in our sample, 5.4% experienced major complications from a benign gynecologic surgery. Complications from benign gynecologic surgery are rare, even in the absence of robotic equipment. Center-specific data and a discussion of the increased morbidity associated with with prior abdominal surgery and emergency surgery should be considered for pre-operative patient counselling.
PROACTIVE MONITORING FOR SMEs USING APPINSIGHT
Authors: Buja Atdhe
Published: October 2022

Data Security is a worldwide concern mostly for small medium enterprise (SMEs) and frameworks, approaches, methods are constantly evolving that has a connection with cloud computing, information systems, artificial intelligence, blockchain. Many developers, administrators or product teams running blind. Those are not knowing of problems with their application or do not have the information to fix the problems. The things which can go wrong with web and mobile applications or services is unlimited like dependency failures, resources, and crashes. Main argument is an evaluation of benefits by using Cloud as infrastructure and application on proactive monitoring called Azure Application Insights (AppInsight) towards target like web application, web API, PKI etc. The findings, demonstration of the study should reveal and support our main hypothesis that there is direct link between the proactive monitoring and the main factors that affects utilizing the cloud services. To address this need, in this paper, we introduce AppInsight, the best practice and a model of proactive approach to monitor different targets using Microsoft technology on Azure Cloud services. AppInsight – a model of proactive monitoring includes several functionalities: (1) identifying availability, (2) failures dependencies, (3) performance and (4) using telemetry data generates ad-hoc solution to fix potential failure of web application, web API etc. AppInsight a feature of Azure Monitor used to monitor live applications. AppInsight will automatically detect performance anomalies, and includes powerful analytics tools to help you diagnose issues. You will get a range of telemetry data of analytics of your target which is monitored by AppInsight. To evaluate this tool, we conduct an empirical evaluation by comparing data from actual live monitoring of Y target. Demo Video: https://www.youtube.com/watch?v=q7R8-c0ge7M
Ketro Tourist Village: Community Empowerment Through the Village Tourism Program Economic Recovery Strategy to Welcome to The G20 Presidency
Authors: Musofiana Ida , Saputri Aprilia Rizki
Published: October 2022

There are many benefits and impacts of tourism development and development if it is planned and directed properly. The development of Indonesian tourism as a whole is the result of the work of various parties including the Government, the private sector, and the community. The national tourism development policy is an effort to encourage actors in the tourism sector to achieve the goals outlined and the goals set. This article aims: to explain the concept of Ketro Tourist Village and its implementation strategy. This community service uses a qualitative method with an emphasis on descriptive research. The results of this community service show that the Ketro Tourist Village concept is to encourage actors in the tourism sector in achieving the goals outlined and the goals set, it is believed that the tourism sector is a mainstay sector that can contribute to increasing the country's foreign exchange, both directly and indirectly. And the implementation strategy of Ketro Tourist Village in the implementation of Tourism Development in an area is carried out to spur growth both physically and non-physically. Based on this understanding, it is important that the objectives of the implementation of tourism development, especially in Sragen Regency, include the Arrangement of Tourism Facilities and Infrastructure b). Increase various potentials around the reservoir. c). Development of Tourism Objects by establishing a Home Stay as a Tour Package. Whereas the implementation of Tourism Development in Sragen Regency has had a significant impact on the existence of social changes both in terms of economy and in terms of Social and Cultural aspects.