bluuebunny/crossref_metadata_2025 huggingface dataset:
A RETROSPECTIVE STUDY OF MEDICATION-RELATED OSTEONECROSIS OF THE JAW IN MULTIPLE MYELOMA PATIENTS
Authors: Savio Melzer Rafaela , Santos-Rodrigues Danielle , Guebur Maria Isabela , Sassi Laurindo Moacir , Ignácio Sérgio Aparecido , Batista Rodrigues Johann Aline Cristina
Published: December 2023

Background: Multiple myeloma is a malignant hematological neoplasm, whose treatment involves the use of bisphosphonates and monoclonal antibodies, which may be related to medication-related osteonecrosis.

Objective: The present study aims to verify the presence of medication-related osteonecrosis of the jaws in patients undergoing treatment for multiple myeloma who used chemotherapy associated or not with bisphosphonates and/or monoclonal antibodies. Beyond this, to trace the epidemiological profile of patients who developed medication-related osteonecrosis.

Methods: This 15-year retrospective observational study consisted of evaluating 461 medical records of patients diagnosed with multiple myeloma from the oncology referral hospital in Brazil, Erasto Gaertner Hospital.

Results: It was observed that both the group that developed osteonecrosis and the group that did not develop, no statistically significant difference when evaluated separately regarding sex, bone marrow transplant and ethnicity. However, the group with osteonecrosis showed a higher frequency in the use of bisphosphonates, did not progress to death, were non-smokers, the mandible was the most affected anatomical site, and the type of bone exposure spontaneously was the most observed.

Conclusions: The combined use of pentoxifylline and tocopherol was responsible for the successful resolution of cases of medication-related osteonecrosis. Isolating the underlying disease allowed for greater control and knowledge regarding the medications used for the treatment of medication-related osteonecrosis.
BUMDes dan Perekonomian Desa: Studi Kasus Desa Busuk Jaya Kecamatan Inuman Kabupaten Kuantan Singingi Provinsi Riau
Authors: Gustrianti Helsi , Wicaksono Baskoro
Published: December 2023

Penelitian ini bermaksud menjelaskan mengenai peran BUMDes dalam meningkatkan perekonomian masyarakat Desa Pulau Busuk Jaya. Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan deskriptif, sumber data dan informasi dalam penelitian ini berasal dari keterangan informan baik itu dari Pemerintah desa, Pengurus BUMDes, masyarakat desa, dokumen-dokumen dan jurnal-jurnal hasil penelitian. Hasil penelitian ini adalah Peran BUMDes dalam meningkatkan perekonomian masyarakat desa belum terlaksana dengan baik, yang mana ditemukan beberapa permasalahan yang dihadapi BUMDes Desa Pulau Busuk Jaya karena pendirian BUMDes di desa ini masih terbilang baru, adapun permasalahannya yaitu :pertama, pemilihan jenis usaha BUMDes di desa Pulau Busuk Jaya yang belum memanfaatkan potensi yang ada di desa, sehingga mengakibatkan sering bergantinya jenis usaha yang dikelola karena tidak berkembangnya usaha yang dijalankan. Kedua, di dalam pengelolaan BUMDes baik itu antara Pemerintah desa dengan BPD ataupun dengan masyarakat desa yang mana ditemukan masih rendahnya inisiatif pemerintah dan masyarakat desa dalam mendirikan dan mengelola BUMDes. Ketiga, permasalahannya terdapat pada Sumber Daya Manusianya, diketahui bahwa BUMDes memang memiliki beberapa dimensi sosialnya, akan tetapi BUMDes merupakan usaha atau bisnis. Oleh sebab itu, untuk dapat mengelola BUMDes tersebut tentunya pengelola harus memiliki jiwa entrepreneur atau wirausahawan yang dapat melakukan aktivitas wirausaha, dengan begitu BUMDes dapat tumbuh dan berkembang.
Aktivacija mladih u hrvatskom društvu
Authors: Botrić Valerija
Published: December 2023

Prethodna istraživanja ukazuju na smanjenje tradicionalnih oblikaaktivacije mladih u hrvatskom društvu. Pri tome se financijskaograničenja koja potencijalno utječu na participaciju mladih čestone analiziraju eksplicitno, već implicitno putem socioekonomskogpoložaja mladih u društvu. U ovom se radu analizira u kojoj mjerimlade osobe same navode financijska ograničenja kao preprekuza aktivnije sudjelovanje u društvu. Rezultati se temelje na fokusgrupama i anketnom istraživanju provedenima u proljeće 2021. godine.Istražuju se faktori povezani s financijskim ograničenjima, kao što sukarakteristike kućanstva i karakteristike sredine u kojoj mlada osobaživi, ali i karakteristike same mlade osobe. Rezultati očekivano pokazujuda financijska ograničenja najviše dolaze do izražaja kod aktivnosti kojezahtijevaju značajnija sredstva, kao što su turističke, sportske i glazbeneaktivnosti. Rezultati istraživanja mogu doprinijeti boljem razumijevanjurazloga zbog kojih dolazi do smanjenja aktivnosti mladih u društvu.
Kedekatan Emosional Polri terhadap Masyarakat dalam Merespons Program Prioritas Kapolri terkait Pemantapan Komunikasi Publik, Perspektif Ilmu Psikologi
Authors: Himawan Agung -
Published: December 2023

ABSTRAK

Tujuan penelitian ini untuk mendeskripsikan langkah dan capaian Polri khususnya Polrestabes Surabaya dalam membangun kedekatan emosional Polri terhadap masyarakat dalam rangka merespons program prioritas Kapolri terkait pemantapan komunikasi publik. Penelitian ini merupakan tipe penelitian deskriptif kualitatif, dimana sumber data berupa data primer dan sekunder serta teknik pengumpulan data dengan cara studi pustaka, wawancara, dokumentasi dan pengamatan. Setelah data terkumpul dianalisis menggunakan instrument yang disampaikan oleh Lindsey Antin, (2016) terkait variabel kedekatan emosional dapat terbangun, jika instrument kebutuhan emosional individu terpenuhi dan oleh Stewart L. Tubbs & Sylvia Moss, (2005) terkait indikator tercapainya variabel komunikasi publik efektif guna memperoleh jawaban dari pertanyaan peneliti. Hasil dari penelitian menemukan bahwa (1) langkah Polrestabes Surabaya terkait pemenuhan kebutuhan emosional individu telah diupayakan, yang ditandai dengan perilaku mendukung dan menemani warga, perilaku simpati dan empati, menanggapi curhatan dan keluhan masyarakat serta mencari dan menemukan solusi, mampu memberikan dukungan terhadap masyarakat berprestasi dan menyalurkan hobi serta minat; (2) indikator tercapainya komunikasi publik oleh Polrestabes Surabaya terhadap warga masyarakat, sebagai akibat dari terbangunnya kedekatan emosional dapat dilihat dari sejumlah kegiatan tatap muka seperti Jumat Curhat, Jumat Berkah, Patroli Sambang dan lain sebagainya, dimana personil Polri telah mendengarkan keluhan warga dengan baik dan mampu memberi saran pada saat diminta oleh warga untuk sebuah saran, mampu berupaya menemukan dan mencarikan solusi terkait penyebab dari sebuah permasalahan warga, personil Polri mampu melakukan suatu tindakan dan mempengaruhi sikap warga untuk bersama-sama menjaga kamtibmas, personil Polri mampu meningkatkan kekompakan dan hubungan sosial antar warga.

Kata kunci : kedekatan emosional, komunikasi publik, harkamtibmas
Evaluasi Peralatan Dalmas dan PHH Polri dalam Rangka Persiapan Pengamanan Pemilu 2024
Authors: Raslin Harvin
Published: December 2023

Dalam menjalankan tugas pokok memelihara keamanan dan ketertiban dalam negeri, Kepolisian dituntut untuk melakukan antisipasi terhadap gangguan Kamtibmas. Pola pelayanan yang diutamakan adalah strategi himbauan (pre-emptif) dan pencegahan (preventif) guna mengantisipasi aksi unjuk rasa yang anarkis sehingga dapat dicegah agar tidak meluas. Dalam menghadapi Pemilu tahun 2024, kesiapan peralatan Dalmas satuan Samapta dan PHH satuan Brimob baik perorangan maupun kesatuan perlu dievaluasi, sejauh mana peralatan Dalmas dan PHH diwilayah sudah memadai baik dari kuantitas maupun kualitas. Penelitian ini menggunakan metode campuran (mixed method) yang merupakan gabungan antara metode kuantitatif dan kualitatif dengan total jumlah responden sebanyak 2.635 orang. Dari hasil penelitian dan analisa, dapat disimpulkan bahwa kondisi riil peralatan Dalmas dan PHH dalam aspek kuantitas masih cukup memadai. Namun, terdapat beberapa peralatan yang perlu ditambah khususnya bagi satuan wilayah yang sering menghadapi massa. Adapun peralatan yang perlu ditambah yaitu tameng, helm, tongkat, senjata laras licin dan gas air mata. Dari segi kualitas bahan material, beberapa peralatan yang tergelar di lapangan ditemukan banyak yang mengalami pecah, retak, kendor, dan soak seperti senjata laras licin, kaca helm dan tameng. Selain itu, perlu peningkatan kelayakan mutu pada peralatan Dalmas dan PHH yang akan digunakan dalam rangka persiapan pengamanan Pemilu 2024 maupun dalam situasi lainnya. Peningkatan kelayakan mutu ini diperlukan untuk kenyamanan dan perlindungan bagi personel itu sendiri saat menghadapi atau benturan dengan masyarakat. Sehingga, disimpulkan bahwa perlu adanya penambahan peralatan dan peningkatan kualitas bahan material pada peralatan Dalmas dan PHH sebagai upaya meningkatkan kelayakan mutu peralatan dalam menjaga keamanan dan ketertiban dalam negeri
Strategi Penanganan Pengaduan Masyarakat (Dumas) Guna Meningkatkan Profesionalisme Anggota Polri
Authors: Aziz M Asrul
Published: December 2023

Dari sisi public complaint (pengaduan masyarakat), menurut Ombudsman, Kepolisian RI termasuk salah satu instansi penyelenggara pelayanan publik yang "langganan" dikeluhkan. Bahkan, beberapa tahun terakhir Polri selalu masuk 8 sampai 5 besar nasional sebagai lembaga yang paling dikeluhkan. Untuk mengatasi hal itu, Kapolri Jenderal Listyo Sigit Prabowo memasukkan 5 program prioritas terkait pelayanan publik dan penanganan pengaduan masyarakat di antara 16 Program Prioritas Kapolri. Kemudian pada tanggal 24 Februari 2021 Kapolri juga meluncurkan aplikasi Dumas Presisi serta untuk lebih menekankan pentingnya kerja sama dan sinergitas lintas fungsi dan sektoral terkait penanganan pengaduan masyarakat, Kapolri mengeluarkan Surat Edaran Kapolri Nomor: SE/5/II/2021 tanggal 24 Februari 2021 tentang Sistem Informasi Penanganan Pengaduan Masyarakat Terintegrasi di Lingkungan Polri. Penelitian ini dilakukan di 11 Polda dan 54 Polres. Pengumpulan data dilakukan dengan penyebaran kuesioner kepada masyarakat yang pernah membuat pengaduan ke Polri dan operator Dumas, FGD dengan pejabat utama di Polda dan Polres, serta FGD dengan para operator pelayanan pengaduan masyarakat. Hasil penelitian menunjukkan bahwa responsivitas, keteryakinan, transparansi, dan akuntabilitas pelayanan pengaduan masyarakat oleh Polri berada pada level moderat. Masih banyak personel, baik di Polda maupun Polres, yang belum memahami konsep Sentra Pelayanan Dumas Terintegrasi (SPDT) dan implementasinya. Mayoritas personel Polri yang diadukan/didumaskan mengeluhkan terjadinya pemeriksaan/gelar perkara berulang kali dengan kasus yang sama, baik oleh pihak internal maupun eksternal. Bahkan, banyak personel yang tetap harus menjalani pemeriksaan, padahal penanganan dumasnya sudah selesai
INFORMATIVENESS OF TRANSIENT AND TWO-DIMENSIONAL SHEAR WAVE ELASTOGRAPHY IN ASSESSING OF LIVER STIFFNESS IN POST-COVID-19 AND CARDIOHEPATIC SYNDROMES
Authors: Diomidova Valentina N. , Valeeva Olga V. , Vasilyeva Lidiya N. , Razbirina Ekaterina A.
Published: December 2023

Ultrasound elastography of diffuse liver diseases allows to assess liver stiffness and predict the further course of the disease, determine the tactics of patient’s management for post-Covid and cardiohepatic syndrome. The purpose of the research – to study the diagnostic informativeness and evaluate the correlation between one-dimensional and two-dimensional shear wave elastography technologies with elastometry in assessing liver stiffness in patients with post-COVID and cardiohepatic syndromes. Materials and methods. A comparative analysis of the information content and correlation between the results of one-dimensional and two-dimensional shear wave elastography of the liver was carried out in 85 patients with post-COVID (N1; n = 30) and cardiohepatic (N2; n = 25) syndromes. The control group (N3; n = 30) consisted of patients without the new coronavirus infection COVID-19 and without any pathology of the liver and biliary system. In the control group, the study of liver parenchyma stiffness using shear wave elastography was carried out by lobes and segments. Standard variation statistics algorithms were used, taking into account the type of data distribution in the statistical analysis. Quantitative indicators with a normal distribution were described using arithmetic means (M) and standard deviations (SD), boundaries of the 95% confidence interval (95% CI). In the absence of a normal distribution, quantitative data were described using the median (Me) and lower and upper quartiles (Q1–Q3). Research results. The stiffness values (Emean) in the projection of segments VI, VII had larger values (p = 0.02) when compared with other segments. We obtained the following Emean values in transient elastography: in the group of patients with post-COVID syndrome (N1) – 10.02 kPa; in the group of patients with chronic heart failure (N2) – 14.09 kPa, which turned out to be significantly higher than the stiffness of the liver parenchyma among healthy individuals, where the Emean value was 4.90 kPa (p = 0.05). With shear wave elastography, the results were also higher in the group of patients with chronic heart failure (N2), where Emean was 20.90 kPa, compared to the group of patients with post-COVID syndrome (N1) – 11.86 kPa. Conclusions. The results of shear wave elastography were successful in 100% of cases, the results of transient elastography in 84.6% of cases. Correlation analysis of connections in a group of patients with chronic heart failure according to TE and SWE showed a weak positive direct linear correlation. A positive direct linear correlation of medium strength was obtained in assessing the correlation in the group of patients with post-COVID syndrome.
PSORIATIC ARTHRITIS: PROBLEMS AND SOLUTIONS (CASE REPORT)
Authors: Zhuravleva Nadezhda V. , Aksionova Angelina V. , Yakupova Svetlana P. , Ivanova Anastasia V. , Smirnova Tatyana L. , Kupriyanov Sergey V.
Published: December 2023

The purpose of this study is to evaluate the effectiveness of therapy for psoriatic arthritis with tumor necrosis factor inhibitor α–Adalimumab. Material and methods. Retrospective and prospective analyses of psoriatic arthritis course were performed in a patient along with a comprehensive examination before and after administering therapy with a tumor necrosis factor inhibitor α-Adalimumab. The diagnosis of the patient was made on the basis of psoriatic arthritis classification criteria, the assessment of psoriatic rashes was performed according to PASI index. The laboratory study included complete blood cell count and biochemical blood tests. The patient underwent X-ray examinations of the joints and magnetic resonance imaging of the lumbosacral spine in the STIR mode. Study results. The patient's first manifestations of psoriasis were detected at the age of 12 years. At the age of 22, the patient had pain in the lower back of VAS 2-3 points, as well as enthesites in the area of the lateral epicondyle of humerus, wings of the iliac bones, trochanter major, the upper edge of the patella and tibial tuberosity, the PASI index was 17.3 points. In order to relieve pain, the patient took non-steroidal anti-inflammatory drugs. Against the background of therapy with non-steroidal anti-inflammatory drugs, the intensity of pain in the lower back decreased, but enthesites persisted. At the age of 35, the patient was diagnosed with psoriatic arthritis, activity III, stage II, dactylitis, enthesites, PASI index 38.5 points; right-sided active sacroiliitis, ASDAS ESR index activity was 3.92 points, joint functional insufficiency of the 2nd degree. Methotrexate therapy was prescribed. There was no positive dynamics against the background of treatment, in connection with this, therapy with genetically engineered biological drugs was initiated. We observed positive dynamics in the clinical course of psoriatic arthritis when Adalimumab was included in the treatment: after the 2nd week of treatment, the articular syndrome subsided, joint pain decreased when evaluated on a scale of 2-3 points, the number of psoriatic plaques on the trunk and limbs decreased as well, the index of psoriatic rashes was 5.3 points. After 8 weeks from the start of therapy with Adalimumab, regression of pathological skin rashes was noted, the index of psoriatic rashes was 0 points. Conclusions. Therapy with Adalimumab in the patient resulted in regression of psoriatic manifestations on the skin, suppression of psoriatic arthritis activity. The study showed the clinical effectiveness of a genetically engineered biological drug – Adalimumab in achieving persistent clinical remission of psoriatic arthritis.
ASSESSMENT OF THE MARKET VALUE OF AGRICULTURAL LAND
Authors: Sokolova Galina N.
Published: December 2023

The issues of assessing the market value of agricultural land are considered. The purpose of the study is to analyze the specifics of determining the market value of agricultural land, and the factors affecting their value. Materials and methods. The study used approaches to assessing the market value of agricultural land, the regulatory framework governing the process of determining the market value, as well as the principles that guide the appraiser in determining the value of the object. Study results. The analysis of approaches and methods used in assessing the market value of agricultural land has shown that existing methods do not fully take into account the specifics of the assessed object in terms of determining the risks, which may eventually affect the market value. The market value of an agricultural land plot is influenced to a greater extent by natural factors, on which the efficiency of agricultural production depends, which should be taken into account when determining its value by a profitable approach. The Order of the Ministry of Property of the Russian Federation dated March 6, 2002 № 568-r (as amended on July 31, 2002) "On Approval of Methodological Recommendations for Determining the Market Value of Land Plots" contains instructions on determining the capitalization rate for the method of land rent capitalization and the method of intended use, in which calculation is reduced to doubling the risk-free income rate. As a result, it can be said that natural factors are not taken into account when calculating the market value of agricultural land plots. Based on the analysis, the factors determining the market value of agricultural land plots have been identified, which include the location of the site, its distance from the city, terrain and landscape, availability of communications (gas, water, electricity), the category of the land plot and the ways of its possible use, access roads, etc. Based on the correlation method, the main price-forming factors were determined. These include: the distance to the city (remoteness of the plot), the size of the plot, availability of communications. Conclusions. In addition to the general price-forming factors affecting the market value of agricultural land, natural ones can also be distinguished, on which the efficiency of agricultural production depends, which is used within the framework of a profitable approach.
ULUSAL ALAN YAZINDA FEN EĞİTİMİNDE WEB 2.0 ARAÇLARI KONULU ÇALIŞMALARIN SİSTEMATİK İNCELEMESİ
Authors: KARAKUZU Burcu , SARAÇOĞLU Sibel , BEKTAS Oktay
Published: December 2023

21. yüzyıl eğitim paradigması, teknolojik süreçlerin eğitime içerilmesine ve öğrenci merkezli bir yaklaşımın benimsenmesine vurgu yapmaktadır. Web 2.0 araçları, bu amaca hizmet eden eğitsel materyalleri bünyesinde barındırmaktadır. Bu çerçevede mevcut çalışmada fen eğitiminde kullanılan Web 2.0 araçlarına yönelik yapılan araştırmalar derlenmiş ve bir betimsel analiz çalışması yapılarak Türkiye’deki betimsel görünüm ortaya konulmaya çalışılmıştır. Toplamda 45 araştırmanın dâhil edildiği örneklem, 2013 yılından bu yana yayınlanmış olan makale ve tezlerle sınırlandırılmıştır. Elde edilen sonuçlar, Türkiye’de fen eğitiminde Web 2.0 araçlarının derinlemesine analizinin genellikle niceliksel metotlarla gerçekleştirildiğini, nitel çalışmaların sayısının görece az olmasına paralel olarak yeterli sayıda faktörün belirlenemediğini göstermiştir. Öte yandan doktora düzeyindeki çalışmaların sayısının oldukça az olduğu, literatürün bu bağlamda güçlendirilmesi gerektiği belirlenmiştir. Öğrenci merkezli çalışmaların sayıca az olması da Web 2.0 araçlarının etkin kullanımındaki faktörlerin keşfini güçleştiren bir nokta olarak değerlendirilmiş, öğretmen görüşlerinden ziyade öğrencilerin katılımının ön planda olduğu çalışmalarla literatürün zenginleştirilmesi, böylece gelecekte bu alanda çalışma yapmayı planlayan araştırmacılara yol göstermenin gerekli olduğuna işaret edilmiştir.
ÇEVRE SORUNLARINI VE EYLEMLERİNİ ARAŞTIRMA VE DEĞERLENDİRME (ÇSEAD) MODELİNE DAYALI ÖĞRETİMİN ORTAOKUL ÖĞRENCİLERİNİN ÇEVRE OKURYAZARLIĞINA VE KAVRAM ANLAMALARINA ETKİSİ
Authors: KOMBAKÇI Duygu , BENZER Elif , BAYRAM Hale
Published: December 2023

Özet
Bu çalışmada ortaokul 7. Sınıf öğrencilerinin çevre okuryazarlığı düzeylerine ve ekosistem, biyolojik çeşitlilik ve çevre sorunları konularındaki kavramsal anlamalarına “Çevre sorunlarını ve eylemlerini araştırma ve değerlendirme (ÇSEAD)” modelinin etkisini incelemek amaçlanmıştır. Çalışmada öntest-sontest kontrol gruplu yarı deneysel desen kullanılmıştır. Çalışma grubu deney ve kontrol gruplarında 23’er kişi olmak üzere toplam 46 7. Sınıf öğrencisinden oluşmaktadır. Deney grubunda uygulama ÇSEAD modeliyle işlenirken, kontrol grubunda fen bilimleri programına uygun hazırlanan ders kitaplarındaki etkinlikler (PDKE) ile sürdürülmüştür. Her iki gruba da uygulama öncesinde ve sonrasında çevre okuryazarlığını değerlendirmek için İlköğretim Çevre Okuryazarlığı Anketi (İÇOYA) ve kavramsal öğrenmeyi değerlendirmek için araştırmacılar tarafından hazırlanan 21 açık uçlu sorudan oluşan kavram testi (KT) uygulanmıştır. Çevre okuryazarlığının değerlendirilmesinde karşılaştırmalı nicel analizler, kavram testinin değerlendirilmesinde Abraham ve diğerlerinin (1992) kavrama düzeyi gruplandırması kullanılmıştır. Çalışma sonucunda; öğrencilerin çevre okuryazarlığı üzerinde ÇSEAD modeline dayalı öğretim yöntemi lehine anlamlı bir farklılık bulunmuştur. Deney grubu öğrencilerinin kavram öğrenmedeki başarısının kontrol grubuna göre daha fazla olduğu, sontestte tam anlama düzeylerini arttırdıkları ve daha az kavram yanılgısı yaptıkları bulunmuştur. Bu uygulamayla öğrencilerin kendilerini çevre sorunlarının ve yapılması gereken eylemlerin bir parçası olarak gördükleri, bu sebeple uygulama boyunca merak, ilgi ve isteklerinin arttıkları gözlemlenmiştir.
Frequency and course of COVID-19 in patients with rheumatic diseases (according to the data of V.A. Nasonova Research Institute of Rheumatology)
Authors: Kulikov A. N. , Muravyeva N. V. , Belov B. S.
Published: December 2023

The aim of the study was to assess frequency and severity of COVID-19 in patients with rheumatic diseases (RD) who were on inpatient treatment at the V.A. Nasonova Research Institute of Rheumatology. Patients and methods. The study included information on the presence or absence of COVID-19 in the medical history of 6911 patients with immunoinflammatory RD (IIRD) and 362 patients with osteoarthritis (OA) who were on inpatient treatment at the V.A. Nasonova Research Institute of Rheumatology from September 21, 2021 to April 28, 2023. Results. The incidence of COVID-19 in the analyzed IIRD was significantly higher compared to OA (p<0.001). All IIRD included in the analysis are characterized by an increased risk of COVID-19 incidence when compared with OA by 2.7–6.3 times. Patients with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, microcrystalline arthritis, Sjögren’s disease, systemic sclerosis, systemic lupus erythematosus, and ANCA-associated vasculitis were significantly more likely (p<0.02) to receive COVID-19 therapy compared with the control group. Patients with these diseases are characterized by an increased risk of treatment for COVID-19 by 1.9–3.7 times compared with OA. Also, patients with inflammatory joint diseases (IJD), connective tissue diseases (CTDs) and systemic vasculitis (SV) were hospitalized with COVID-19 more often than patients with OA (p=0.01, p=0.007 and p=0.024, respectively). Patients with IJD, CTDs and SV are characterized by an increased risk of hospitalization with COVID-19 by 4.3– 4.7 times compared with OA. In addition, elderly patients with IIRD are characterized by an increasing risk of treatment, hospitalization and use of biologics or targeted synthetic disease-modifying drugs for COVID-19. Conclusion. According to the results obtained, the problem of COVID-19 is significant for patients with RD, which dictates need for further research on vaccination against SARS-CoV-2 among this cohort of patients.
PENGENDALIAN RISIKO KESEHATAN DAN KESELAMATAN KERJA PADA MILL BOILER DI PT PERKEBUNAN NUSANTARA XIV DENGAN METODE HAZOP
Authors: Rayhan Muhammad , Haslindah Andi , Idrus Ilham
Published: December 2023

Kesehatan dan keselamatan kerja (K3) hal yang wajib di terapkan, sebagai tolak ukur bahwa perusahaan itu layak untuk melaksanakan produksi secara aman. Untuk mengetahui risiko kecelakaan kerja, kami melakukan analisis risiko menggunakan metode HAZOP. Tujuanya untuk mengidentifikasi dan mengendalikan bahaya dalam suatu pekerjaan sehingga bahaya pada setiap jenis pekerjaan dapat dicegah dengan tepat dan efektif serta perusahaan dapat melakukan tindak lanjut perbaikan. Hasil analisis risiko di dapatkan bahwa risiko yang kategorinya substansial ada 4 yaitu kulit melepuh, kebakaran, gangguan pernafasan dengan tingkat risiko 90 dan gangguan pendengaran dengan tingkat risiko 150 dimana risiko ini memerlukan tingkat keselamatan tertinggi. Sedangkan yang termasuk dalam kategori priority 3 ada 2 yaitu meledak dan terseret dengan tingkat kategori 50 dimana risiko ini diperlukan pengawasan dan diperhatikan secara berkesinambungan. Sementara yang termasuk dalam kategori acceptable hanya ada 1 yaitu terjatuh dengan tingkat risiko 12,5 dimana intensitas    yang    menimbulkan    risiko    ini    dikurangi    seminimal   mungkin. Pengendalian risiko dibuat berdasarkan jenis risiko yang ada yaitu memasang warning sign disetiap area kerja, menggunakan APD lengkap yang sesuai dengan standar industri seperti masker, helm, sepatu keselamatan, earplug, pakaian anti api, sabuk keselamatan, sarung tangan, serta pada operasional boiler yaitu mengganti control valve dan alat ukur level drum (gelas penduga) otomatis.
PERENCANAAN PRODUKSI AGREGAT DALAM MENGANTISIPASI FLUKTUASI PERMINTAAN DAN MEMINIMALKAN BIAYA
Authors: Azizah Nur , Awal Jumadil , Hanafie Ahmad , Andrie Andrie
Published: December 2023

Perencanaan agregat merupakan perencanaan kegiatan operasional jangka menengah yang memberikan tingkat output agar sesuai dengan tingkat permintaan di masa yang akan datang. Tujuan penelitian untuk mengetahui metode yang digunakan perusahaan dan membandingkan metode yang peneliti usulkan.Adapun Metode yang digunakan yaitu metode peramalan, metode Trend dan Exponensiaal Smoothing, Metode perhitungan EOQ (Economy Order Quantity) dan ROP (Re Order Point). Data yang diperoleh dari perhitungan EOQ untuk membandingkan hasil data Trend (11.711 kg) dan peramalan Exponensial Smoothing (11.111 kg). Dari hasil penelitian ini dapat dsimpulkan bahwa peneliti mampu membandingkan metode peramalan yang perusahaan gunakan dan metode yang peneliti usulkan.
Derechos de la naturaleza y divergencia jurisprudencial en Colombia: un análisis desde el papel de la administración pública de los casos del río Atrato y la Amazonía
Authors: Alvarez Rondón Cristian Camilo , Calderón Moreno Jessica Paola , Calvo Caro Mónica Liliana
Published: December 2023

En Colombia, desde 2016, se reconocen los derechos de la naturaleza mediante sentencias judiciales, confiriendo lineamientos específicos al Estado para materializar, garantizar y proteger este nuevo paradigma. Concretar este escenario, sin embargo, ha presentado grandes retos. En consecuencia, en este artículo se buscó analizar la respuesta de la administración pública frente a la brecha entre los derechos de la naturaleza reconocidos y las capacidades institucionales en sus diferentes niveles de gobierno, a partir de los paradigmas del nuevo constitucionalismo latinoamericano y el giro biocéntrico. Para tal fin, mediante el enfoque cualitativo y el método analítico-crítico, se realizó el estudio de los casos del río Atrato y la Amazonía colombiana, donde se describe la orden judicial y el seguimiento al cumplimiento de sus mandatos. Así, se demostró que, a pesar de los compromisos y responsabilidades para preservar el ambiente, la implementación de estos mecanismos de protección ha enfrentado diversos obstáculos. Como consecuencia, se determina que es necesaria la actualización normativa y organizacional con base en los nuevos preceptos jurídicos que garanticen los derechos ambientales de comunidades y ecosistemas.
The impact of a training approach to develop the speed and level of technical performance of a straight punch according to the different punching distances of young boxers
Authors: Thaer Khamis Ahmed
Published: December 2023

The goal of the research to prepare a training approach to develop the speed and level of technical performance of the straight punch according to the different punching distances according to the different punching distances for young boxers, as well as to identify the impact of the training method in the development of the speed and level of technical performance of straight punches according to the different punching distances of young boxers, and is considered to be the payment of various punches and influential from different punching distances on the competitor and under the changing and rapid punching conditions of the most important factors of the success of the implementation of offensive and defensive duties during the game, where the researcher used the experimental method to solve the problem of research, and was chosen the researcher used the experimental method to solve the problem of research, and was chosen the choice of the researcher The design of the two equal groups with pre and post-tests randomly selected, as the research sample consisted of young boxing players in sports clubs in Diyala province, namely (Baquba, Zuhairat) ages (17-18) years for the category : The training curriculum prepared by the researcher helped greatly in developing the speed and level of technical performance of the straight punch according to the different punching distances of the research sample    members .  The research sample enjoyed a high level in the execution of the straight punch according to the different punching distances, as the average punching distance was characterized by preference followed by the long punching distance and then the short distance . The experimental group enjoyed an advantage compared to the control group in developing the speed and level of technical performance of the straight punch according to the different punching distances of the research sample members. The researcher reached several recommendations  Using the training method prepared by the researcher in training boxing teams for young people to achieve a high technical level and better athletic achievements .  Increase the concentration and attention of the trainers in the training of punches according to different punching distances in parallel. Conduct similar research on different samples and other functional variables.
PENGARUH FUNDAMENTAL SAHAM DAN MAKRO EKONOMI TERHADAP HARGA SAHAM PADA PERUSAHAAN MANUFAKTUR SEKTOR BARANG KONSUMEN PRIMER YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2018-2022
Authors: Darmawan Dahlia , Notoatmojo M. Iqbal
Published: December 2023

This study aims to analyse the effect of Return On Equity, Debt to Equity Ratio, Earning Per Share and Inflation on stock prices using the panel data regression analysis method with the eviews application. This study uses purposive sampling technique in sampling. The samples in this study consist of 14 companies from a total population of 117 manufacturing companies in the primary consumer goods sector listed on the Indonesia Stock Exchange for the period 2018-2022. The results showed that partially Earning Per Share has a significant effect on stock prices, Debt to Equity Ratio has a negative and significant effect on stock prices, while Return On Equity and inflation have no effect on stock prices. While simultaneously Return On Equity, Debt to Equity Ratio, Earning Per Share and inflation affect stock prices.. Keywords: Return On Equity, Debt to Equity Ratio, Earning Per Share, Inflation, Stock Prices.
DETERMINAN LITERASI KEUANGAN PADA GENERASI MILENIA DI KOTA SEMARANG
Authors: Fuadi Faiq , KUSUMAWATI DYAH
Published: December 2023

This research was conducted with the intention of determining the influence of financiaI knowledge, financiaI attitudes and financiaI behavior on financial literacy in the millennial generation in Semarang City. Sampling was taken using an accidental sampling and purposive sampling approach of 101 respondents. Research data analysis uses vaIidity test, reIiability test, correIation coefficient test, coefficient of determination test, simpIe linear regression analysis, multipIe linear regression anaIysis, t test, and F test using the IBM SPSS Statistics version 25 tool. The SPSS test results show that partial financial knowledge and financial behavior variables have a positive effect on financial literacy, while financial attitudes have no effect on financial literacy. Simultaneously all variabIes of financial knowledge, financiaI attitudes, financial behavior have a positive effect on financiaI literacy. There needs to be outreach about the importance of financiaI literacy in schools/ higher education. Apart from that, other research still needs to be carried out with different independent variables. Keywords: financial knowIedge, financial attitudes, financiaI behavior, financial literacy
Hypomagnesemia in Type II Diabetes
Authors: El-Megrabi Rehab
Published: December 2023

Background and aims. Magnesium (Mg) is an important cofactor in a number of important enzymatic reaction and appears to play an important role in glucose metabolism and insulin homeostasis. There is a link between mg deficiency and type 2 diabetes. The present study was conducted to estimate serum mg levels in Type 2 Diabetes Mellitus (DM2) patients and to correlate these levels with pathogenesis. Methods. A total of 70 samples were collected from males and females aged from 20 to 80 years to compare the level of mg in each of them, and the samples were divided into two groups, group1 (n=40) for patients with type II diabetes and group2 (n=30) for healthy people. People with other chronic diseases such as hypertension, heart disease and thyroid disease were excluded. The percentage of mg was determined in the (Dimension RXL Max). Results. About 49 females out of 70 that represent 70% of our community whereas 21 males that represent 30 %. 30 of participants (42.9%) were non-diabetic (Health) while the other 40 participants (57.1%) were diabetic (patients). Although there was a negative correlation between the two variables, this difference was not significant (p =.238). Conclusion. Our research demonstrated an inverse relationship between magnesium levels and HbA1c in individuals with DM2. Our study adds to the existing evidence for this negative correlation, elucidating the intricate connections that give rise to this relationship. To obtain more precise results, future investigations conducted on a broader scale are imperative.
Fiscal Policy and Stock Market Efficiency in Nigeria: Evidence from SVAR Framework
Authors: Danlami Mohammed Ibrahim , Muhammad Sanusi Yakubu
Published: December 2023

This research investigates the impact of fiscal policy on stock market efficiency in Nigeria evidence from SVAR Modelling. The study used quarterly data between 2010Q1 to 2023Q2. Key finding is that shock to public debt caused more fluctuation to stock price in both the short-run and in the long-run by 13.2 per cent and 13.59, respectively. Shocks from government expenditure caused 9.6 per cents and 9.96 per cent fluctuation in stock price in the short and long-run, respectively. A one standard deviation positive shock or innovation to government expenditure caused stock price to fluctuate by 0.73 per cent and 0.75 per cents, respectively in the short and long-run. However, public debt appears to be an effective stock price tool to control and achieve stability in the capital market than the government expenditure and revenue. This study concludes that government should continue to participate more in the stock market for it to grow, since the government stocks constituting the major segments of the bond market. The effective use of fiscal policies, particularly public debt to set the market on the path of growth and development, which would promote investors’ confidence to lessen price bubbling.
TÉCNICAS DE RECONSTRUÇÃO DA CAVIDADE ORBITÁRIA PARA O USO DE PRÓTESE OCULAR E A IMPORTÂNCIA DO CIRURGIÃO BUCO MAXILO FACIAL
Authors: Naves Leandro , Camacho Vallim Paolla
Published: December 2023

A capacidade da visão de interpretar cores, formas e características faciais é inegável. Sua ausência inquestionavelmente altera o equilíbrio facial, levando a mudanças na dinâmica familiar, social e psicológica. Indivíduos que possuem anoftalmia requerem um caminho de recuperação por meio de próteses oculares, permitindo a restauração da estética e do bem-estar psicossocial. Nesse contexto, o objetivo principal deste estudo foi demonstrar através de uma revisão bibliográfica da literatura, a importância do bucomaxilofacial para a população e sua singularidade no meio odontológico, descrevendo as técnicas e métodos utilizados para a confecção da prótese ocular. De acordo com a literatura, a abordagem para tratar defeitos oculares pode ser cirúrgica, protética ou uma combinação de ambas. A reabilitação protética ocular visa restaurar a estrutura perdida de forma artificial, sendo ela realizada por profissionais Bucomaxilofaciais. É de extrema importância possuir conhecimento detalhado da anatomia, criar um protocolo de atendimento, pois diagnósticos rápidos e precisos permitem um tratamento adequado, reduzindo potenciais sequelas, bem como o conhecimento sobre materiais e técnicas empregadas para alcançar resultados estéticos e funcionais satisfatórios. Isso permite uma reabilitação completa do paciente, restaurando sua autoestima e facilitando sua reintegração social.
A Weighted Ensemble Approach with Multiple Pre-trained Deep Learning Models for Classification of Stroke
Authors: Alhatemi Rusul Ali Jabbar , Savaş Serkan
Published: December 2023

Stroke ranks as one of the deadliest diseases globally, emphasizing the crucial need for early diagnosis. This study aims to create a two-stage classification system for stroke and non-stroke images to support early clinical detection. Deep learning, a cornerstone of diagnosis, detection, and prompt treatment, is the primary methodology. Transfer learning adapts successful deep learning architectures for diverse problems, and ensemble learning combines multiple classifiers for enhanced results. These two techniques are applied to classify stroke using a dataset of stroke and normal images. In the initial stage, six pre-trained models are fine-tuned, with DenseNet, Xception, and EfficientNetB2 emerging as the top performers, achieving validation accuracies of 98.4%, 98.4%, and 98%, respectively. These models serve as base learners within an ensemble framework. A weighted average ensemble method combines them, resulting in a remarkable 99.84% accuracy on a reserved test dataset. This approach exhibits promise for stroke detection, a life-threatening condition, while also demonstrating the effectiveness of ensemble techniques in enhancing model performance.
 
Received: 27 October 2023 | Revised: 24 November 2023 | Accepted: 19 December 2023
 
Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.
 
Data Availability Statement
Since the data used in the study were removed from the Kaggle platform after the study was conducted, no data link is provided. However, the study data can be sent to researchers who request it, with privacy and ethical restrictions.
Noncontiguous operon atlas in Staphylococcus aureus
Authors:   , Iturbe Sanz Pablo
Published: December 2023

In previous work from the group, we described the existence of a new transcriptional architecture that we call a noncontiguous operon (NcO). NcOs consist of groups of genes that are transcribed on the same RNA molecule, although genes that are transcribed in the opposite direction separate them. The mRNA of the gene transcribed in the opposite direction is full-length complementary and therefore antisense to the mRNA of the operon. Unlike classical operons, whose presence in the genome is predicted based on theoretical criteria of proximity between genes and biological function of the encoded proteins, the presence of NcOs cannot be determined theoretically and it is necessary to resort to transcriptomic analyses to demonstrate the co-transcription of non-contiguous groups of genes. As a continuation of this line of research, in this thesis we decided to determine the map of NcOs present in the genome of a bacterium. This information would allow us to know the abundance of this transcriptional architecture and thus analyze whether they have common elements or related functions. We decided to use Staphylococcus aureus as a model for four reasons: (I) it is the bacterium in which we first described this transcriptional architecture, (II) we had transcriptomic data obtained from the Illumina platform that could be useful in our study, (III) we have experience in its genetic manipulation and (IV) it has enormous clinical relevance due to its versatility as a pathogen and the existence of multidrug-resistant bacteria.
Propuesta de metodología de documentación aplicada a un proyecto de conservación y restauración de un retablo
Authors: Díaz Parrilla Silvia , Sánchez Fernández Antonio Jesús , Díaz Alemán Manuel Drago , De la Torre Cantero Jorge Luis
Published: December 2023

Documentar los retablos atendiendo a sus características formales y tridimensionalidad es un reto que a día de hoy podemos abordar mediante el uso de técnicas de documentación ya utilizadas en el ámbito de los bienes inmuebles. Este estudio aborda el proceso de elaboración de un modelo digital de un retablo que, mediante una aproximación a la metodología HBIM, captura su configuración física para convertirlo en contenedor de información relativa a aspectos técnicos, estado de conservación e intervenciones realizadas. Dicho proceso contempla una fase previa de aproximación al objeto de estudio, definición de los usos del modelo, y configuración de un entorno de gestión colaborativa a partir del cual poder añadir e intercambiar información. El uso académico del modelo tridimensional garantizará el conocimiento exhaustivo del retablo, siendo inicialmente modelo de consulta y posteriormente de gestión, al registrar las intervenciones llevadas a cabo por el alumnado, con fines didácticos y de divulgación.
Growth performance of three paternal rabbit lines with different potential for growth rate and resilience
Authors: Peixoto-Gonçalves Catarina , Martínez-Paredes Eugenio , Ródenas Luis , Corpa Juan Manuel , Blas Enrique , Cambra-López María , Pascual Juan José
Published: December 2023

This experiment aimed to compare the growth performance, digestive efficiency and health status of three paternal lines for growing rabbits. The R line was selected by growth rate during the growing period for 37 generations; the RF line was founded by selecting a population of elite R animals (average daily gain>60 g/d); and the RFLP line was founded by backcrossing males from the RF line with females from the LP maternal line. A total of 387 weaned rabbits were used to evaluate growing performance from weaning until 63 d of age in individual cages, in three batches. Additionally, 33 animals were used to determine nutrient digestive efficiency in a digestibility trial. Body weight and feed intake were controlled at weaning (28 d), 46 and 63 d of age. Mortality and morbidity were also monitored daily. During the digestibility trial, feed intake and faeces excretion were controlled daily. Results showed no significant effects of genetic type on body weight, daily feed intake and feed conversion ratio throughout the experiment. However, RF animals had a higher average daily gain from 28 to 46 d of age (+4.4%; P<0.05) compared with R animals, but lower from 46 to 63 d of age (–4.3%; P<0.05). Regarding digestive efficiency, RF and RFLP lines showed slightly higher faecal digestibility for dry matter and gross energy of the diet compared with the R line (+1.3 percentage points; P<0.05). Mortality was higher in animals from R and RF lines compared with RFLP (on av. 25.40 vs. 14.06%; P<0.05). Our results suggest that the introduction of resilient genetics could be a suitable strategy to improve the digestive health of paternal lines without affecting significantly their growth performance.
SOSIALISASI MEMBANGUN KARAKTER UNGGUL PESERTA DIDIK MELALUI PENERAPAN PENDIDIKAN KARAKTER DI SEKOLAH
Authors: Iqbal Muhammad , Muharramsyah Rambang , Juwandi  , Dewi Julita , Misraini  , Kubtiah Mariah , Ruhamah  , Ilmi Zikriatun
Published: December 2023

This community service aimed to describe the various strategies carried out by schools in implementing character education through school culture at SMP Negeri 4 Takengon as a form of implementation of the Al-Muslim University collaboration. Character education is the lifeblood of education for the younger generation. To determine the achievement of increasing target participants' understanding and knowledge, instruments were used in the form of pretest and posttest questionnaires before and after the activity. Meanwhile, for feedback on the implementation of subsequent community service activities, participants were asked to respond regarding satisfaction or dissatisfaction with the management of the activity through a satisfaction questionnaire which was distributed directly after the end of the activity. From the implementation of community service  activity,  it was concluded that: 1) the character of students is formed in accordance with applicable values ​​and norms; 2) the formation of superior student character, respecting the process as students, loving others, appreciating and respecting teachers; 3) can identify and map students' character problems so that the solutions offered are in accordance with the characteristics of the problems faced. Especially for teenagers, the teacher is a model that will be imitated by students, so a learning method that combines knowledge, reflection and practice is needed. Thus, a new teacher orientation is needed in educating character, namely the ability to empower and develop society.
Carmen Angolotti y Mesa, compromiso con la persona que sufre
Authors: De Dios-Aguado Mercedes , Aparecida Peters Angela , Milleli Silva Davi , De Oliveira Figueiredo Carvalho Milena , J. Pina Queirós Paulo , Cotto-Andino Maylene
Published: December 2023

En 1921, el protectorado español en Marruecos fue atacado por el cadí rifeño Abd el-Krim, originando la Guerra del Riff. El conflicto tuvo enfermeras heroínas que altruistamente cuidaron a los heridos, sin esperar nada a cambio y exponiendo su vida en peligro. Objetivo: descubrir la vida de Carmen Angolotti y Mesa, enfermera de Cruz Roja Española que siempre mantuvo uncompromiso social con el que sufre. Resultados/Discusión: La Duquesa de la Victoria, dama de la reina Victoria Eugenia de Battenberg, dirigió la misión humanitaria compuesta por enfermeras profesionales, que Cruz Roja Española envió a Melilla, para dar respuesta a la tragedia socio-sanitaria provocada por la Guerra del Riff. En 1925 obtuvo la Medalla Florence Nightingale por su trabajo en la misión. Durante la Guerra Civil Española fue encarcelada y finalmente liberada en1937. Conclusión: Agradecer a Carmen Angolotti su legado en el arte de cuidar a la persona que sufre.