bluuebunny/crossref_metadata_2025 huggingface dataset:
Respon Pertumbuhan Dua Varietas Bawang Merah pada Awal Musim Hujan setelah Pemberian Pupuk Cair Bio-Extrim
Authors: Yiyin Yulistyani Fitri  , I Ketut Ngawit  , Bambang Budi Santoso
Published: March 2023

Penelitian ini bertujuan untuk mengetahui pertumbuhan dua varietas bawang merah pada berbagai konsentrasi pupuk cair Bio-Extrim yang ditanam pada awal musim hujan. Penelitian dilaksanakan di Dusun Mertak, Desa Kawo, Kecamatan Praya, Kabupaten Lombok Tengah pada bulan September sampai November 2021. Rancangan percobaan yang digunakan adalah Rancangan Petak Terbagi (Split Plot Design) dengan dua faktor. Faktor pertama adalah varietas bawang merah (v) terdiri atas dua aras yaitu varietas Maserati (v1) dan varietas Lokananta (v2). Faktor kedua adalah konsentrasi pupuk cair Bio-Extrim (e) terdiri atas enam aras yaitu (e0): kontrol (tanpa Bio-Extrim), (e1): disemprot Bio-Extrim 5 ml/L air, (e2): 10 ml/L air, (e3): 15 ml/L air, (e4): 20 ml/L air, (e5): 25 ml/L air pada umur tanaman 2, 4, dan 6 MST. Seluruh kombinasi perlakuan yang diulang enam kali sehingga didapatkan 36 unit percobaan. Hasil penelitian menunjukkan bahwa tidak adanya interaksi antara varietas dan pupuk Bio-Extrim terhadap semua parameter pertumbuhan. Demikian pula halnya dengan masing-masing perlakuan, berpengaruh tidak nyata terhadap pertumbuhan bawang merah.
PARALISIA CEREBRAL E INTEGRAÇÃO SENSORIAL DE AYRES: ESTUDO DE CASO
Authors: Barbosa Aracely Kalaf , Silva Renata Costa Sá e , Montenegro Karina Saunders
Published: March 2023

A Encefalopatia Crônica Não Progressiva Infantil (ECNPI),
mais conhecida como Paralisia Cerebral (PC), foi descrita em 1843, por William John Little, durante um estudo com crianças com espasticidade, realizou um levantamento do histórico de nascimento e
constatou intercorrências durante o parto ou ainda nas primeiras horas
de vida (BRASIL, 2013).
Sua etiologia é multifatorial, com origem pré, peri ou pósnatal, sendo as causas pré-natais responsáveis por cerca de 75% dos
casos de PC, como: infecções maternas durante o período gestacional, traumas, fatores congênitos, histórico de convulsões e tireoidopatias (ZANDONÁ et al., 2022).
ATUAÇÃO DO TERAPEUTA OCUPACIONAL COM INTEGRAÇÃO SENSORIAL DE AYRES: RELATO DE EXPERIÊNCIA EM UM CENTRO ESPECIALIZADO EM REABILITAÇÃO, EM RIO BRANCO - ACRE
Authors: Alves Cleomara Martins Nery , Costa Maria de Fátima Góes da
Published: March 2023

Diariamente, os seres humanos estão expostos a diferentes
tipos de sensações e, naturalmente, ocorre um processo neurológico natural, chamado de Integração Sensorial, fenômeno neurofisiológico, resultado da recepção, percepção, interpretação e associação de múltiplos estímulos sensoriais (ARAÚJO, 2020).
OS BENEFÍCIOS DA TERAPIA DE INTEGRAÇÃO SENSORIAL SOB A ÓTICA DOS PAIS/CUIDADORES DE CRIANÇAS COM TEA
Authors: Santos Altamira dos Reis , Aguiar Elísia Sampaio , Caçula Elizângela Gonçalves , Vieira Maria Helena Santana , Silva Talita Luana dos Santos , Montenegro Karina Saunders
Published: March 2023

O Transtorno de Espectro Autista (TEA) é definido, de acordo
com o Manual Diagnóstico e Estatístico dos Transtornos Mentais (DSM-V), como um transtorno do euro desenvolvimento que se manifesta nos primeiros anos de vida. Destaca-se as dificuldades
comunicativas (verbais e não verbais), sociais, de participação,
comportamentos estereotipados e isolados que interferem diretamente no desempenho ocupacional do indivíduo (CARDOSO; BLANCO, 2019).
USO DA TECNOLOGIA PARA O AUMENTO NA ARRECADAÇÃO MUNICIPAL: IMPACTO NA GESTÃO FISCAL DOS MUNICÍPIOS
Authors: Alves Rodrigo , Guimarães Thauan Almeida
Published: March 2023

Este artigo tem como objetivo analisar o uso de tecnologia e estratégias para o aumento na arrecadação municipal em modo geral. Para isso, foi realizada uma revisão bibliográfica e análise de dados oficiais de municípios brasileiros. Os resultados mostraram que a utilização de tecnologia e estratégias para a arrecadação de tributos municipais é uma tendência atual e pode contribuir significativamente para o aumento da arrecadação. Além disso, foi constatado que a adoção de medidas para estimular o pagamento dos impostos pelos contribuintes é uma das formas mais eficazes de aumentar a receita própria do município.
The anatomist’s perspective today towards human body donation for procurement of cadavers for study of human anatomy
Authors: Bharambe Vaishaly Kishore , Prasad Arun , Bokan Raju , Kalthur Sneha , Manvikar Purushottam , Puranam Vatsalaswamy
Published: March 2023

Anatomy is the study of structure of human body. Dissection of human cadavers has always been an integral part of study of anatomy as well as research in it. Till now the only source for cadavers for dissection purposes were unclaimed bodies. Today the need for bodies for medical education has increased and most medical schools are experiencing difficulties in procuring the requisite number of cadavers. Body donation programs may help fulfil this need of the medical schools. The present study was an attempt to analyze the attitude of the anatomists towards different aspects of body donation. 24.7% of the participants stated that they have insufficient cadavers, 12.3% claimed surplus cadavers while 62.8% claimed sufficient cadavers. 26% of the anatomists were unaware of the necessity for a death certificate and 35% were unaware of the necessity for a unique identification document for carrying out body donation.
Potential antiviral activity of eleutherine, isoeleutherine, eleuthinone and elecanacine compounds in Eleutherine palmifolia (L.) Merr against NSP3 SARS-COV-2: In silico study
Authors: Belia Bima Nafisa  , Sanarto Santoso  , Zainabur Rahmah  , Roihatul Muti’ah
Published: March 2023

Eleutherine, isoeleutherine, eleuthinone and elecanacine are secondary metabolites of Dayak onion (Eleutherine palmifolia (L.) Merr) belonging to the naphtoquinone group and considered to have antiviral activity by inhibiting HIV replication. These considerations were used in this study using the Non-structural protein 3 (NSP3) in SARS-CoV-2 which plays a role in virus replication. This study aims to predict the antiviral activity, physicochemical properties and toxicity. Antiviral activity predictions were reviewed based on the interaction of the ligand with the NSP3 receptor (PDB ID: 7JIT) using Molegro Virtual Docker 6.0. Prediction of physicochemical properties refers to the Lipinski Ro5 and parameters of TPSA using swissADME. Toxicity prediction based on LD50 classification and AMES toxicity, hapatotoxicity, skin sensitization parameters using ProTox-II and pkCSM. The results showed that all the compounds in the study had inhibitory activity in terms of Rerank Score (RS) which represents the form of bound energy and were compared with Ribavirin as the comparator drug. The RS (Kcal/mol) for eleuthinone is -102.853, isoeleutherine -108.493, eleuthinone -108.005 and elecanacine -104.640. The RS of all compounds was lower than Ribavirin (-94.195) indicating higher affinity than Ribavirin. All the compounds in this study matched the Lipinski’s Ro5 and TPSA parameters with LD50 in toxicity class IV and were predicted to be safe, except for elecanacine which was predicted to be mutagenic and eleuthinone which was predicted to be hepatotoxic. So that, overall eleutherine and isoeleutherine compounds can be recommended as candidates for SARS-CoV-2 antiviral compounds.
Periodic Limb Movement (PLM) sleep disorder and diagnosis
Authors: Mohd. Maroof Siddiqui  , Ruchin Jain
Published: March 2023

Periodic Limb Movement (PLM) Sleep Disorder is a type of sleep disorder characterized by involuntary and repetitive movements of the limbs, which can lead to sleep disturbances and disruptions. It is a common condition that can affect people of all ages and can significantly impact quality of life, In this paper review the symptoms, diagnosis, and treatment of PLM Sleep Disorder. In this paper discuss the various methods for diagnosing PLM Sleep Disorder, including polysomnography. Additionally, In this paper discuss the importance of timely diagnosis and treatment of PLM Sleep Disorder to improve quality of life for those affected by this condition.
Study of acid base imbalance in organophosphorus poisoning in intensive care patients of eastern Gujarat tribal region
Authors: Rocelyn Josekutty  , Pramod S. Kamble  , Kishor N. Chinchodkar  , Meghalatha TS
Published: March 2023

Organophosphorus (OP) pesticides poisoning can result from occupational, accidental or intentional exposure. The compounds can be absorbed through skin, conjunctiva, oral mucosa, GI tract or respiratory tract. This study aimed to analyze arterial blood gas (ABG) analysis and serum cholinesterase (SC) activity in OP poisoning, to study clinical correlation of OP poisoning with the help of ABG analysis and SC and to compare factors of OP poisoning patients and control group. A total, 156 OP poisoning cases and 156 control participants were included in this study. The ABG and SC sample was processed at Central Clinical Biochemistry Laboratory, Medical College and Hospital, in a tertiary health care in eastern Gujarat. Most of the OP poisoning cases were young people 80% (<50 years of age) with mean±SD age as 26.41±11.28 years (range: 11-80). Among these 90(57.69%) and 66(42.31%) were females and males respectively. While control participants with mean±SD age as 29.97±15.75 (range: 15-85) and male were 103(66%) and 53(34%) were females. Significant difference was found out between the age, Electrolytes: Na+, K+, Cl- and SC (p<0.001), mean SC level in patients with the latent grade of poisoning was 1363.24±1326.76 IU/L, which is clinically significant (p<0.001), no significant difference found between pH, pCO2, pO2, HCO3act and HCO3std (p>0.05). This study concluded that mortality is directly proportionate to the amount of OP substances consumed, clinical severity of poison, SC levels, ABG analysis and electrolytes level in blood. This study can be improving survival or reduces mortality in patients with organophosphorus insecticide poisoning.
Toxicity of single and ternary mixtures of heavy metals and 2,4-dichlorophenoxyacetic acid to Chlorella vulgaris alkaline phosphatase activity
Authors: Romanus Ugochukwu Onyeukwu  , Emeka Sabastine Asiwe  , Christian Okechukwu Nweke  , Vivian Kelechi Gaius-Mbalisi
Published: March 2023

The influence of mixtures of metals and pesticide on the activity of algal hydrolytic enzyme alkaline phosphatase was investigated. Toxicity of unary and ternary combinations of Copper (Cu2+), Zinc (Zn2+), Lead (Pb2+), Chromium (Cr2+), Cadmium (Cd2+) ions and 2,4-dichlorophenoxyacetic acid (2,4-D) was assessed via inhibition of phosphatase enzyme activity of Chlorella vulgaris. The effects of the amalgamated ternary mixtures were studied in their fixed percentage ratio of 20:40:40 and 40:30:30. Results obtained showed that all the unary heavy metal ions were toxic to algal phosphatase activity, with a concentration dependent inhibition of alkaline phosphatase activity. The analysis of eco-toxicity concentration (EC50) of toxicant ternary mixtures of metals/ pesticides mixtures in 20:40:40 ratios show that the ternary mixtures 2,4-D/Pb2+/Cd2+and 2,4-D/Zn2+/Cd2+ were more toxic, followed by 2,4-D/Cu2+/Cr2+, 2,4-D/Pb2+/Zn2+, 2,4-D/Cu2+/Zn2+ and 2,4-D/Cu2+/Cd2+. Whereas among the 40:30:30 mixture ratios 2,4-D/Pb2+/Cd2+ and 2,4-D/Zn2+/Cd2+ were most toxic. The decline in the trend of their toxicity strength was followed by 2,4-D/Cu2+/Cr2+, 2,4-D/Cu2+/Zn2+, 2,4-D/Cu2+/Cd2+, 2,4-D/Cu2+/Pb2+ and 2,4-D/Pb2+/Zn2+. In addition, the least toxic amongst them were the 2,4-D/Pb2+/Cr2+, 2,4-D/Zn2+/Cr2+ and 2,4-D/Cr2+/Cd2+ ternary mixtures. Toxicity index analysis of the mixture interaction effect showed that the mixtures of heavy metals with 2,4, D were mostly antagonistic with toxic index (TI) >>1, However, exceptions were the 2,4-D/Pb2+/Cd2+ and 2,4-D/Pb2+/Cd2+mixture which were additive and synergistic with TI=1 and TI<1 respectively. From the foregoing study, the toxicity of the mixtures exhibited largely sigmoidal relationship, increased composition of heavy metal in the mixture resulted in a potentiation of 2,4-D toxicity. These results indicate that mixtures of heavy metals with largely non-toxic 2,4-D may pose ecological risk to freshwater microalgae Chlorella vulgaris, presenting antagonistic, additive and synergistic toxicity interactions based on their relative occurrence in the mixture.
Case Report: An interesting case of a patient who presented with increasing thirst and polyuria in a district general hospital in the UK
Authors: Indrajit Talapatra  , Upasya Mukherjee
Published: March 2023

A gentleman presented with polyuria and polydipsia to the Endocrine Clinic in late 2020. The patient was investigated extensively. Diabetes Mellitus was excluded, and the patient was investigated for Diabetes Insipidus (DI). The patient was passing more than 3L of urine/day. A Water deprivation Test (WDT) was done, and it suggested Partial Central Diabetes Insipidus (Partial Arginine Vasopressin Deficiency), which is a rare disorder. Various blood tests looking for the aetiologies such as Sarcoid, Germinoma, IgG4 Disease and Vasculitis were negative. MRI scan of the Pituitary carried out twice showed no abnormality. The patient’s distressing symptoms were alleviated with proper treatment (nasal Desmopressin). Thus, it is important to diagnose this treatable condition which is often confused with Primary Polydipsia. The patient has since then been clinically and biochemically well.
PERANCANGAN TATA LETAK GUDANG PADA TOKO PELITA MAKMUR MENGGUNAKAN METODE ANALISIS ABC
Authors: Haupea Lailatul Jannah , Tutuhatunewa Alfredo , Afifudin Moh. Thezar
Published: March 2023

Gudang merupakan salah satu aspek penting dalam dunia industri. Peranan gudang sebagai tempat untuk menyimpan barang dalam jumlah banyak yang sangat berperan besar baik bagi industri besar maupun industri kecil. Salah satu industri yang menggunakan fasilitas gudang adalah toko Pelita Makmur yang menyediakan aneka produk sembako maupun kebetuhan rumah tangga lainnya, dengan luas gudang yang dimiliki seluas 160 . Penempatan produk yang digunakan oleh perusahaan adlah metode randomized atau produk ditempatkan secara acak. Tujuan penelitian ini adalah membuat proporsi space penimbunan produk, jalur lalu lintas handling (Aisle), tata letak gudang yang lebih efisien dengan menggunakan metode ABC dengan mengelompokan produk ke dalam 3 kelas berdasarkan tingkat perputaran dari produk selama jangka waktu tertentu yaitu kelompok A sebanyak 20%, kelas B 30% dan kelas C 50%. Berdasarkan hasil pengolahan data, luas area gudang yang digunakan untuk penempatan produk pada layout perbaikan, ditentukan area gudang seluas 80,2 dan penggunaan pallet sebanyak 66 buah. Dengan menggunakan metode manhattan, jarak tempuh yang dilakukan pekerja untuk pengambilan produk sebesar 22.594 meter jika menggunakan metode perusahaan. Sedangkan jika menggunakan metode ABC jarak yang digunakan adalah 20.551 meter atau mengalami penurunan sebesar 0,09%.
한국민사소송법학회 창립 30주년을 기념하여
Authors:   Korean Association Of The Law Of Civil Procedure, 김 경욱
Published: March 2023

Anlässlich des 30. Jahrestages der Gründung der Koreanischen Vereinigung für Zivilprozessrecht wurde dieser Aufsatz mit der Absicht verfasst, auf die vergangenen wissenschaftlichen Errungenschaften des zivilprozessrechtlichen Gebiets zurückzublicken, und gleichzeitig einen Diskussionsansatz zu bieten, um effizientere und rationellere Zivilprozessverfahren vorzubereiten. In dieser Studie möchte ich einige Probleme untersuchen, die im Bereich unseres Zivilverfahrensrechts in der vergangenen Zeit als selbstverständlich angesehen wurden oder an deren Verbesserung trotz Kenntnis der Probleme nicht aktiv gearbeitet wurde. Schwerpunktthemen sind: (i) Wiederherstellung der Position zur Streitgegenstandstheorie, (ii) Auferlegung von Verzugszinsen auf Verzugszinsen, (iii) Verstärkung des Konzentrationsgrundsatzes und des Vorbereitungsverfahrens für die mündliche Verhandlung, (iv) Verbesserung der Struktur des Berufungsverfahrens, (v) die Folge der Veräußerung des in Streit befangenen Gegenstandes, (vi) Bedarf an zusätzliche Wiederaufnahmegründe (vii) Unterschied zwischen sofort und unverzüglich.
미국의 소송이송 간주제도(Removal)
Authors:   Korean Association Of The Law Of Civil Procedure, 정 영환
Published: March 2023

Comparative civil procedure scholars often encounter foreign civil procedure different from their own. To understand and translate terminology of the foreign civil procedure have been challenges. For such work, analyzing functions and roles of the specific procedure is crucial. ‘Removal’ in U.S. civil procedure is one example of such foreign procedure. This article examines procedural aspects of the removal. Part II of this article reviews concept, definition, and grounds of removal by comparing it with transfer and remand that have similar functions. Part III examines i) party-related requirements of removal; ii) claim-related requirements; and iii) timing of filing notice of removal. Part IV looks into the procedure of removal with more details; and Part V describes effects of removal. In Part VI, based on functions and roles of removal in U.S. civil procedure, this article provides suggestions for Korean civil procedure with regard to enhancing defendants’ defenses in choice of jurisdiction. Such recommendations include i) recognition of the parties’ right to move for transfer when the litigation is filed at a court that does not have a jurisdiction; and ii) ways to use transfer of civil litigations more actively in intellectual property cases. This article provides an opportunity to contemplate on what to learn from foreign civil procedure to improve Korean counterpart.
민사소송에서의 AI 알고리즘 심사
Authors:   Korean Association Of The Law Of Civil Procedure, 한 애라
Published: March 2023

Automated decision-making by AI algorithms is increasingly likely to cause civil liability. However, AI algorithms based on machine learning techniques are less explainable due to technical inscrutability arising from the nature of the learning methods itself, legal opacity due to protection of trade secrets or intellectual property rights, or incomprehensibility of the general public or judges due to the complexity and counterintuitiveness of algorithms, thus making its judicial review difficult. When the mechanism of an AI algorithm is at issue in a lawsuit, the question is how an opaque AI algorithm can be evaluated by experts and reviewed by a court. This article first introduces ACCC v. Trivago decision made by the Federal Court of Australia in 2020, focusing on how the experts appointed by each party presented their opinions on the AI algorithm and how the court drew its conclusion based on their opinions. It then studies issues and solutions that may arise in examining opaque AI algorithms in the Korean civil litigation procedures, making comparison with the Trivago decision. It explains basic features of Explainable AI(XAI) methods including Ante hoc methods and post hoc methods. It then points out problems of the Civil Procedure Act and Intellectual Property laws of South Korea in disclosing data necessary for the experts’ analysis on the AI algorithms and in protecting the trade secrets contained in the produced data, and makes suggestions on how to solve those problems. Lastly, it recommends a more active use of party-appointed experts in the judicial review of the AI algorithms by allowing their active participations throughout the litigation procedure in order to clarify issues and deepen the court’s scientific understanding.
Implementasi Kebijakan Penyaluran Dana Desa Dalam Pengelolaan Bumdes di Desa Pandan Landung dan Desa Jedong Kecamatan Wagir
Authors: Noviana Fransiska , Sasmito Cahyo , Widi Lestari Asih
Published: March 2023

The purpose of this study was to find out how the implementation of channeling village funds in the management of BUMDes in Pandan Landung Village and Jedong Village, Wagir District, Malang Regency, to find out and examine the variables that can help and hinder the implementation of village fund distribution in the management of village-owned enterprises. Methods of collecting information using descriptive qualitative with observation, interviews, and documentation. The results of the study found that BUMDes policies in Pandan Landung Village and Jedong Village could be implemented effectively based on the Van Meter Van Horn policy implementation model. Policy size and objectives, capital resources, inter-organizational communication, social conditions, and human resources are supporting factors for implementing BUMDES management of village fund distribution in Pandan Landung Village and Jedong Village. Barriers to the implementation of BUMDes management, such as firstly the lack of socialization of the Village government to the community, secondly there is still an apathetic community, thirdly the lack of adequate time and human resources that need to be added so that they can run effectively due to one another's busyness and lack of finance and natural resources in two village.
Optimalisasi Ketahanan Energi Melalui Kebijakan Pengurangan Konsumsi Gas Elpiji di Indonesia
Authors: Sianipar Ronald
Published: March 2023

This article aims to analyze energy security policies in Indonesia related to reducing the use of fossil energy by increasing the use of renewable energy. The problem is focused on the idea of the Government of Indonesia to switch the use of Liquefied Petroleum Gas (LPG) based energy to electricity-based energy, especially for household consumers. To approach this problem, theoretical references from scarcity and energy security theories are used, related to current LPG-based energy management in Indonesia and plans for the future. The data were collected through secondary data, literature review, and field studies and were analyzed qualitatively. The results of this study indicate that renewable energy used as a basis for electrical energy is expected to reduce dependence on fossil energy, namely LPG gas. The policy accompanying this energy transition uses a price ceiling policy on LPG gas and an alternative LPG policy. Government policy emphasizes the ceiling price, which sets the highest retail price (HET) for LPG gas. This alternative policy is supported by the use of electricity from renewable energy, including water, wind, biomass, and solar. Another energy alternative is new energy, namely dimethyl ether (DME), which is obtained from processed coal with low calories. In terms of implementation, to maintain a stable supply in the market, it is necessary to monitor and evaluate so that The Gass can still maintain the gas supply and It can control the energy demand for households.
Intranasal Administration of a Polymeric Biodegradable Film to C57BL/6 Mice
Authors: Balafas Evangelos G , Papakyriakopoulou Paraskevi I , Kostomitsopoulos Nikolaos G , Valsami Georgia N
Published: March 2023

Nasal drug delivery in rodents is a challenging procedure, especially for brain targeting, as the position of the material in the nasal cavity determines the success of the administration method. The objective of this study was to assess a novel intranasal administration technique for
nose-to-brain delivery of biodegradable nasal films. The method was performed in C57BL/6 (n = 10; age, 8 wk) under inhaled sevoflurane. Twenty-four gauge catheters were used for the procedure. Hydroxypropyl methyl-cellulosebased film was formed in the lumen of the catheter and then
delivered into the mouse nostril by pushing it out of the lumen using a trimmed and polished needle. Methylene blue was incorporated in the film-forming gel to indicate the delivery area in which the films were deposited. After administration, all mice recovered from anesthesia without incident.
None of the mice showed any signs of injury, discomfort, or nose bleeding, thus allowing us to characterize the administration method as noninvasive. Furthermore, postmortem evaluation revealed olfactory-centered placement of the polymeric films, confirming the accuracy and repeatability of
the method. In conclusion, this study documented the use of, a novel, noninvasive, intranasal administration technique for nose-to-brain drug delivery in biodegradable films for use in mice.
NOTION “ARCHITECTURE” IN THE CONTEXT OF CONTEMPORARY VIRTUAL ART DEVELOPMENT (ON EXAMPLE OF A VIDEO GAME)
Authors: USPENSKYI M.S. , USPENSKYI M.S. , NESTERENKO V.V.
Published: March 2023

Problem statement. The relevance of the article is due to recent changes that have occurred due to appearance of a large number of new contemporary art genres and types, which have appeared due to mixing, combining existing ones, caused by the advent of new technologies. This led to quantitative changes in the situation in the general systemic classification of arts as well as to the blurring of the boundaries between traditional arts and created the need to search for a specification of each art content and architecture, in particular. The problem is defined by the lack of certainty in relation to the notion of architecture. The purpose of the article. In accordance with it, the goal to redefine the notion of architecture is made. Methods. The method of semantic analysis was chosen as the main one to formulate a notion definition of architecture based on the definition of a video game. Conclusions. To achieve the purpose, the following tasks are solved. In classifying the arts according to the type of carrier and the type of time change, video games is selected as the art form with the most common features. A comparison of video game and architecture is made by examples of their practical joint application. Examples of the gaming technologies implementation into software products assigned for architects, examples of video games indirect influence at the development of technical means, examples of the architecture tools use in the creation of games are listed. A retrospective of the game notion definition from ancient times to the present day is examined. The researches concerning the notion definition of the game in modern society are analyzed. A number of differential features of the video game notion definition are highlighted and the video game notion definition is formulated. Based on the notion definition of video game, the notion definition of architecture is formulated. The possibility of drawing such parallels between the video game and architecture creates the need for further research of the game in the context of architecture.
ANALYSIS OF THE ATMOSPHERIC AIR POLLUTION DYNAMICS USING THE METHOD OF NUMERICAL SIMULATION
Authors: BILIAIEV М.М. , BERLOV O.V. , KOZACHYNA V.A. , NOCHVAI V.I. , RUSAKOVA T.I.
Published: March 2023

Problem statement. The task of assessing the level of atmospheric air chemical pollution in the case of an extreme situation resulting in a heptyl spill on the territory of industrial facility is considered. An analysis of the pollution zones formation both at industrial sites and in the residential area located near the industrial facility is conducted. To solve such a problem, it is necessary to develop multifactor mathematical models that allow for the rapid determination of the pollution areas formed in an extreme situation. The purpose of the article. To develop a computer model for operational analysis of pollution areas formed during the emergency emission of chemically hazardous substances into the atmosphere. Methodology. The computer model was developed on the basis of a numerical model, which is a differential analogue of the multifactor kinematic equation for impurities mass transfer in atmospheric air. The mass transfer equation takes into account the three-dimensional field of wind speed, atmospheric diffusion, and the intensity of the chemically dangerous substance release into the air. A four-step finite-difference splitting scheme is used for numerical integration of the three-dimensional mass transfer equation. Determination of the chemically dangerous substance concentration at each cleavage step is implemented according to an explicit formula. An empirical dependence is used to calculate the emission intensity of a chemically hazardous substance from the emergency spill zone. Scientific novelty. A numerical model was developed and its software implementation was conducted for the operational analysis of the formation of accidental pollution areas in the atmosphere. The model takes into account a complex of factors affecting the process of impurity propagation in the atmosphere. Practical value. A program was developed for calculating the dynamics of atmospheric air pollution based on the proposed numerical model. This makes it possible to analyze the consequences of emergency spills on the territory of chemically hazardous objects by the method of a computational experiment. Conclusions. An effective tool for operational analysis of the atmospheric air pollution level due to the emission of chemically hazardous substances is created. The results of the computational experiment are presented.
LEGISLATIVE AND NORMATIVE FRAMEWORK FOR THE REGULATION OF PERSONNEL ISSUES IN THE EDUCATION OF FUTURE SPECIALISTS IN THE SPECIALTY 029 “INFORMATION, LIBRARY AND ARCHIVE AFFAIRS”
Authors: PROKOFIEVA K.A. , RESHETILOVA O.M. , SAVCHENKO S.V.
Published: March 2023

The training of students in the specialty 029 “Information, Library and Archive Affairs” (according to the educational and professional program “Documentation and information activity”) requires an understanding of the document management and the coverage of several documentation systems. During solving general issues, they reflect the regularities and peculiarities of one or another field of activity. One of such systems is personnel documentation. Highlighting the specifics of personnel records management is important for understanding its place in the management system. This raises the issue of determining the personnel documentation role in the organization management processes, its analysis in terms of the functions performed. The study of personnel records management as a separate subsystem in documenting managerial actions is the basis of this article. The relevance of the issues considered in the work is due to the modern development of the Ukrainian economy. Today, the issues of organizing an effective system of work with personnel in enterprises, institutions and organizations are becoming increasingly important. In this regard, the role of personnel records management is growing and the analysis and improvement of the organization of the personnel service work is of particular relevance. Personnel management as a social activity based on a legal and regulatory framework. A number of legislative and regulatory acts regulates labor relations: laws of Ukraine, decrees of the Cabinet of Ministers of Ukraine, orders of ministries and other higher state bodies. These documents form the basis and define the specifics of personnel records management as an activity for formalizing labor relations.
코로나 팬데믹 대응 수단으로서 행정집행과 행정행위, 그리고 헌법적 과제
Authors:   Korean Public Land Law Association, Shin Okju
Published: March 2023

Die Bedeutung der Existenz des Staates liegt im Schutz der Sicherheit von Leben und Körper von Menschen. Nach Art. 34 Abs. 6 Koreanischer Verfassung wird bekräftigt, dass der Staat Katastrophen verhüten und Menschen vor Gefahren schützen muss. Art. 36 Abs. 2 KV statuiert das Recht der Menschen auf Gesundheit. Es ist ein Verstoß gegen staatliche Pflichten, wenn der Staat angesichts der Corona 19-Pandemie Leben und Körper seiner Bevölkerung nicht angemessen schützt. Die koreanische Regierung, die ‘koreanischen Agentur für die Kontrolle und Prävention von Krankheiten’ und die lokalen Regierungen gewinnen gute Ergebnisse mittels aktiver epidemiologischen Untersuchung und des Infektionskrankheitenmanagementes, indem sie während der Corona 19 Pandemik den Verwaltungszwangs und die Verwaltungsuntersuchungen bei der Bekäpfung und Verhinderung der Ausbreitung von Infektionskrankheiten fast ohne Grenze einsetzen. Wichtiges Merkmal von Bekämpfungsmassnahmen Koreas auf COVID 19 liegt darin, dass sie sich auf die Prävention und Eindämmung der Ausbreitung von Infektionskrankheiten durch strenge behördliche Untersuchungen und behördliche Anordnungen auf der Grundlage der Sammlung umfangreicher personenbezogener Daten konzentriert. Sie erhielt zwar international positive Bewertungen, aber wegen der umfangreichen Datebsammlung und des vernetzten integrierten Datenverarbeitens kann man auch hinsichtlich des Datenschutzes kritisch bemerken.
Decius & Valerian, Novatian & Cyprian: Persecution and Schism in the Making of a Catholic Christianity - Part I
Authors: Bryant Joseph M.
Published: March 2023

To be presented is a two-phased historical-sociological study of “turning points” (Part I) and altered “trajectories” (Part II). In the mid-third century, two successive persecutions of Christians would be unleashed by the emperors Decius and Valerian. Those coercive efforts at suppressing the offending "superstitio" were empire-wide in scale, unprecedented in planned efficiency. Under Decius, a universally mandated requirement to offer sacrifices to the gods was backed by monitoring commissions and compliance certificates that featured confirmations of accomplishment and, most ominously, sworn, signed, and notarized declarations of lifelong religious orthopraxy. Great numbers of Christians complied with those directives—either by offering the demonic sacrifices outright or by securing fraudulent certificates attesting to having done so—actions that voided, through idolatrous trespass, the “celestial promise” of eternal life that had been gifted in the baptismal rite of spiritual rebirth. Efforts at resolving the ensuing crisis of mass apostasy split the mainstream Church into competing factions of disciplinary hardliners who resisted, and pragmatic reformers who endorsed the readmission of apostates. Drawing upon Schismogenesis and Sect-Church theories, I examine the course of this schism—doctrinally and demographically—to show how the socially induced and expedited trend towards penitential lenity, as adopted by the majority Catholic variant, facilitated the triumph of Christianity in the Roman Empire. The persecution and the schism it provoked carried greater world-historical significance than has hitherto been realized.
Chemical Oxygen Demand (COD) Analysis Ink Printing Waste Water Using Titrimetry Method
Authors: Khristiani Suhari Dian , Pujiastuti Peni
Published: March 2023

The printing industry produces wastewater from the ink used. Contains organic and inorganic pollutants such as lead, cadmium, chromium and zinc. Having a quality that exceeds the quality standards for wastewater. If it is discharged into the environment it can pollute the receiving water body. Need to do an analysis of organic pollutant content, by measuring the parameters of Chemical Oxygen Demand (COD). Determination of COD numbers in printing industry wastewater ink using titrimetry method (SNI 6989.73: 2009). Perform oxidation-reduction titration using Ferro Ammonium Sulfate (FAS) solution in printing industry ink wastewater. This study conducted three sampling replications. The results of the first day research obtained a COD rate of 33,088 mg /L; second day 69,694.6 mg /L; third day 67,830.4 mg /L. All three samples had COD figures exceeding the printing industry wastewater quality standard of 125 mg / L. Printing industry wastewater is not suitable to be discharged into the environment.

Abstrak
Industri percetakan menghasilkan limbah cair dari tinta yang digunakan. Mengandung polutan organik dan anorganik seperti timbal, kadmium, kromium, dan zink. Memiliki kualitas yang melebihi baku mutu air limbah. Apabila dibuang ke lingkungan dapat mencemari badan air penerima. Perlu dilakukan analisis kandungan polutan organik, dengan mengukur parameter Chemical Oxygen Demand (COD). Penentuan angka COD pada air limbah tinta industri percetakan dengan menggunakan metode titrimetri (SNI 6989.73:2009). Melakukan titrasi oksidasi-reduksi menggunakan larutan Ferro Amonium Sulfat (FAS) pada sampel air limbah tinta industri percetakan. Penelitian ini melakukan tiga kali ulangan sampling. Hasil penelitian hari pertama diperoleh angka COD sebesar 33.088 mg/L; hari kedua sebesar 69.484,6 mg/L; hari ketiga sebesar 67.830,4 mg/L. Ketiga sampel memilik angka COD melebihi baku mutu air limbah industri percetakan sebesar 125 mg/L. Air limbah tinta industri percetakan tidak layak dibuang ke lingkungan.
The Link Between COVID-19 and Executive Functions in the Geriatric Population: A Descriptive Cross-Sectional Study
Authors: ÇEBİ Merve , KAPLAN Oğuzhan
Published: March 2023

Background: Geriatric population is known to be at a greater risk for the Coronavirus-19 (COVID-19). Previous literature provided evidence for the association between viral infections and cognitive decline. The aim of this study was to evaluate executive functions in older adults who were infected by COVID-19.

Methods: A total of 47 participants with healthy cognition over the age of 65 (M:75.4±5.91, minimum-maximum:65-85) were enrolled in the study. The sample was selected from older adults residing in a nursing home in Istanbul. Based on their history of COVID-19 infection, the sample was divided into two groups as COVID-P (22 participants who got Covid-19 in the last six months) and COVID-N (25 participants who did not get Covid-19) which did not significantly differ in terms of age and education. A mini mental state examination was applied to verify the mental status of participants. Trail Making Test (TMT) and Clock Drawing test (CDT) were used to assess executive functions.

Results: The analyses showed that COVID-P group displayed significantly lower performance in the completion of both forms of TMT as compared to COVID-N group (p< .05 for both TMT-A and TMT-B). However, groups did not significantly differ in their CDT performance (p> .05).

Conclusion: Based on the findings, it is possible to conclude that COVID-19 can negatively affect the executive functions in the old age population.
Interstitial and Cornual Ectopic Pregnancy: A Review of the Management Options
Authors: Yang Evelyn , Liu Yung-Liang
Published: March 2023

Interstitial or cornual ectopic pregnancies are a rare form of ectopic pregnancy which account for 2% to 4% of all ectopic pregnancies. While it is a rare type of ectopic pregnancy, the mortality rate is 6–7 times higher than other ectopic pregnancies. Therefore, early recognition and accurate diagnosis of an interstitial or cornual ectopic pregnancy is critical for the safety and wellbeing of the patient especially due to the increased risk of massive hemorrhage. Treatment options include conservative medical management with methotrexate or surgical intervention with laparoscopy or laparotomy.
Detection of HPV Infection and the Current Status of Vaccine Research: A Review
Authors: Su Liuli , Peng Hongling , He Xiang
Published: March 2023

Objectives: Purpose of this narrative review is to comprehensively summarize and compare the methods of human papilloma viruses (HPV) detection to provide a reference for clinical selection. And it also concludes the research progress of preventive HPV vaccines and therapeutic HPV vaccines to provide new ideas for the future development of HPV vaccines. Mechanism: A comprehensive search of published relevant articles was conducted. Multiple database were searched including PubMed, SCOPUS, and Ovid. Searches included the key terms: human papilloma viruses (HPV), HPV infection, epidemiology, HPV vaccine, cervical cancer (CC) screening, detection technology. Findings in Brief: HPV is a sexually transmitted virus and also a common cause of female reproductive tract infections. HPV has been reported to be associated with approximately 5% of human cancers worldwide, among which high-risk HPV (HR-HPV) infection is the most closely related to cervical cancer. The advantages of using HPV testing for cervical cancer screening are the high long-term negative predictive value (NPV), the high sensitivity (90–95%) for cervical intraepithelial neoplasia (CIN) 2 or 3, and the significant reduction in CIN2/3 and cancer in test-negative women over long term follow-up. The current detection of HPV infection is mainly for HPV DNA, RNA and oncoprotein, and vrious methods have their own features. Currently, there is no treatment for an HPV infection, so prevention is the key to cancer reduction. HPV vaccine is an important means to reduce the incidence rate of HPV infection and HPV related cervical cancer. Conclusions: With the development of assay technology, assays with low cost, high versatility and operability will be needed in the future. The HPV vaccine, as a primary prevention measure for cervical cancer, has achieved significant results in preventing HPV infection and reducing the incidence of reproductive tract diseases. In the future, it is expected that the HPV vaccine will make significant breakthroughs in the treatment of current HPV infections and cervical cancer.
Current Non-Invasive Imaging Techniques Used in the Diagnosis of Adenomyosis
Authors: Săsăran Vlăduț , Mărginean Claudiu , Pușcașiu Lucian
Published: March 2023

Objective: This review aims to provide insights into the current non-invasive imaging methods used in the diagnosis of adenomyosis, as well as to highlight their diagnostic accuracy, advantages, disadvantages and limitations in the detection of this benign uterine condition. At the same time, this paper emphasizes the importance of using consensus-based terminology in the imaging description of these lesions. Mechanism: A search of PUBMED database was conducted for articles published between January 1998 and August 2022 and studies which compared non-invasive imaging methods with postoperative histology examination of uterine specimens were primarily selected. Transvaginal two-dimensional ultrasound was for a long time the main non-invasive imagistic method used for assessment of adenomyosis lesions. The introduction of Morphological Uterus Sonographic Assessment (MUSA) group criteria yielded a significantly better diagnostic outcome of adenomyosis in case of conventional ultrasonography, but the distinction of concomitant benign uterine conditions still remained challenging. Findings in Brief: The addition of three-dimensional ultrasound or elastosonography to conventional two-dimensional transvaginal ultrasound yielded higher diagnostic sensitivity. Qualitative elastography particularly proved useful in the diagnosis of adenomyosis due to its capacity to achieve differential diagnosis of benign uterine pathologies based on lesion stiffness. Magnetic resonance imaging (MRI) examination presents higher diagnostic specificity and sensitivity, can assess the endometrial and myometrial layers in detail, but its use has been shadowed by costs and significantly longer examination time. Conclusions: The imaging terminology established by consensus by the MUSA group in recent years has facilitated the description of adenomyosis-specific lesions. Two-dimensional transvaginal ultrasound in combination with three-dimensional ultrasound or combined with qualitative elastography offers similar diagnostic sensitivity and specificity to MRI. Despite some limitations, MRI remains a reliable diagnostic method for adenomyosis.
Efficacy of Probiotics in the Treatment of Adult Female Bacterial Vaginosis: A Meta-Analysis
Authors: Shan Yuping , Cui Zicheng , Ding Zhaoxia , Yao Yushuang , Chen Aiping
Published: March 2023

Background: The purpose of this meta-analysis was to assess the value of probiotics in the treatment of adult female bacterial vaginosis (BV). Methods: We looked for published randomized controlled trials in PubMed, Embase and The Cochrane Library from the inception dates of the database to January 3rd, 2022. We conducted the search focusing on the treatment of adult female BV with probiotics. Two independent researchers screened the literature, evaluated the trial quality and extracted the data according to the inclusion and exclusion criteria. The primary outcome was the ratio of patients with BV with recurrence according to Nugent score 7–10 for recurrence after treatment. After heterogeneity was assessed using Review Manager 5.4 software, meta-analysis and bias assessment were performed using Stata 17.0 software. Results: A total of 5 articles representing 425 patients were included in this meta-analysis. Compared with antibiotics alone or antibiotics combined with a placebo, probiotics or probiotics combined with antibiotics significantly reduced the rate of recurrence at around the 30th day (risk ratio (RR) 0.11; 95 % confidence interval (CI) 0.03–0.33). However, in the analysis of heterogeneity, we found that after 30 days, the therapeutic effect of probiotics decreased with the extension of follow-up time (RR 0.50; 95% CI 0.24–1.03), (RR 1.24; 95% CI 0.88–1.76). Conclusions: The short-term efficacy of probiotics in the treatment of BV in adult female patients may be satisfactory, but the long-term efficacy of probiotic therapy may be suboptimal and still requires validation by further clinical trials.
Perinatal Care during the COVID-19 Pandemic
Authors: Liu Chia-Chen , Fann Li-Yun , Koo Fan-Hlan , Weng Shih-Han , Chiu Ting-Fang , Cheng Chih-Chien
Published: March 2023

Background: Following the pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), and considering its capacity for rapid mutation, there have been many studies and articles on this novel coronavirus over the past three years. Therefore, providing knowledge and directions for management of SARS-CoV-2, for hospital staff is crucial. Hence, we collected the research information from different perspectives and summarized the guidelines for perinatal care on the topic of SARS-CoV-2, and for possible future viral pandemics. Methods: A systematic review aimed at assessing the publications written in English and Chinese, offering different perspectives on the topic of perinatal care concerning SARS-CoV-2, was conducted using PubMed and Google Scholar from 2020 to 2022. In addition, we summarized the guidelines from the Taiwan Association of Obstetrics and Gynecology, American College of Obstetricians and Gynecologists, Society for Maternal-Fetal Medicine, Maternal Immunization Task Force and Partners, and Academy of Breastfeeding Medicine. Results: Due to physiological changes, pregnant patients may be prone to have complications, especially pre-eclampsia, affecting morbidity and mortality. Most neonates of coronavirus disease (COVID-19) infected mothers did not show any clinical abnormalities due to the infection. However, compared to the general population, infected neonates needed more invasive ventilation care, while the proportion of asymptomatic neonates was less than that in the general population. Further, long term complications are still under investigation. Evidence of vertical transmission via the placenta and umbilical cord is rare but not absent. Paxlovid (nirmatrelvir/ritonavir) can be administered to patients with comorbidities, and indications for cesarean delivery does not include COVID-19 infection. Vaccination against COVID-19 should not be delayed during pregnancy and lactation. Conclusions: Obstetricians and gynecologists should pay more attention to pregnant women with SARS-CoV-2 because of the physiological changes and higher risks of complications, morbidity, and mortality. Early prevention with vaccination in pregnant women is the key to controlling the COVID-19 pandemic, from which we can learn how to manage the next pandemic.