bluuebunny/crossref_metadata_2025 huggingface dataset:
HIPERCAPITALISMO, FLEXIBILIZAÇÃO E METAMORFOSES NO TRABALHO MÉDICO
Authors: Ferreira Mário César , Silveira Ana Lígia Bacca Fontana da , Bezerra Bianca de Barros , Frausto Carla Itzuri Guerrero Frausto , Pontes Gabriel Teles , Aguiar Ricardo Saraiva , Costa e Silva Jordana
Published: August 2023

As transformações aceleradas que se operam no mundo do trabalho no limiar do século XXI vem impactando significativamente as atividades profissionais nas organizações. Nesta entrevista, o Prof. Dr. Josep Blanch aborda o novo paradigma forjado pelo hipercapitalismo que vem reconfigurando o significado do trabalho e a prática da medicina. Ele argumenta que tais transformações são indissociáveis da vivência de conflitos e contradições entre os imperativos funcionais da nova ordem sanitária e os valores, normas, crenças, papéis e padrões morais de comportamento profissional. O Prof. Dr. Blanch, psicólogo, é altamente qualificado para tratar da temática em foco. Ele possui carreira acadêmica sólida, cuja referência central é o trabalho realizado na Universidade Autônoma de Barcelona (UAB/ES), vasta produção bibliográfica acadêmica, experiência internacional relevante com destaque em países da América Latina. Sua expertise profissional também se expressa pelos títulos de Professor Emérito na UAB e o obtido no Ministério da Ciências da Colômbia como Pesquisador Emérito. A entrevista nasceu da Roda de Conversa promovida na disciplina Trabalho e Cognição do Programa de Pós-Graduação em Psicologia Social, do Trabalho e das Organizações (PPG-PSTO) da Universidade de Brasília (UnB). O coletivo de estudantes de pós-graduação (entrevistadores) elaborou questões prévias que foram respondidas durante uma live com quase duas horas de duração.
Research on the Strategy of Promoting the Coordinated Development of Grand Canal Water Transport and Other Transport Modes, Taking Jiangsu as an Example
Authors: Fang Ling , Cheng Xin , Yao Guanxin
Published: August 2023

With the realization of the Grand Canal's full water supply and the strong pursuit of green and low-carbon transportation in contemporary society, the value of the Grand Canal's water transport has been further affirmed, and its coordinated development with other transportation modes has become inevitable and important. This paper analyzes and combs through the characteristics, development status and existing problems of Grand Canal water transport and other transport modes in depth, and takes Jiangsu as an example. A collaboration model of Grand Canal water transport and other transport modes was built and their collaboration degree has been calculated. It is believed that the coordinated development of Grand Canal water transport and other transport modes can be greatly promoted via four aspects: optimizing the construction and governance of Grand Canal water transport, building an integrated management platform of transport modes, improving the integrated transport network structure, and promoting the deep integration of integrated shipping and tourism.
Los programas de medicina de precisión y los desafíos para la gestión de la salud pública
Authors: Foladori Guillermo , Bracamonte-Aramburo Ericka
Published: August 2023

Varios países iniciaron programas para el desarrollo de medicina de precisión. Con miles o millones de datos de salud, priorizando los mapas genéticos, mediante inteligencia artificial se elaboran algoritmos que identifican subpoblaciones con susceptibilidad a determinadas enfermedades para luego establecer la correspondencia farmacogenómica con las medicinas adecuadas. Este artículo realiza una acotada caracterización de esta propuesta y sistematiza aspectos críticos para su implementación desde una perspectiva de salud pública. Dados los argumentos expuestos, resulta probable que la medicina personalizada lleve a una mayor desigualdad entre países y regiones y al interior de los diferentes sectores sociales
Analysis of e-learning readiness level implementation in islamic senior high school south jakarta, indonesia: Review in biological learning
Authors: Muslim Muhammad Hisan Alfani , Zulfiani Zulfiani
Published: August 2023

The utilization of E-Learning as one of the innovations in learning provides a richer and more flexible digital learning experience, where learning can be done anytime and anywhere without being limited by space or time. Its use requires good physical and mental readiness so that e-learning can run optimally. This study aims to determine the level of readiness for the implementation of e-learning in Islamic Senior High School South Jakarta, Indonesia. A survey method was used in this study, survey data were collected through a questionnaire adapted from the Aydin & Tasci ELR model which uses four factors of readiness namely human, self-development, technology, and innovation. The four factors are constructed from resources, skills, and attitudes. The sample in this research is Islamic Senior High School in South Jakarta, Indonesia. The results showed that Islamic Senior High School in South Jakarta was categorized as ready and could be continued in implementing e-learning (Mtotal=4.24 > 4.21). There are two factors that are categorized as ready and can be continued, namely technology and innovation factors, the other two factors, namely human beings and self-development are categorized as ready but need a little improvement. The resource aspect is the main focus in human factors, self-development, and innovation that requires a little improvement. These factors can be the focus of attention. They can be used as a reference for Islamic Senior High School A in South Jakarta in making improvements and improvements in the implementation and utilization of e-learning.
The The effect of indonesian local culture integrated students' environmental awareness on sdgs: pls-sem approach
Authors: Yolida Berti , M. Sinaga Risma , Maulina Dina , Supriyadi Supriyadi
Published: August 2023

Various ways have been carried out in the world of education to raise environmental awareness for students, but the efforts so far have not had a significant impact on sustainable development. Students have not fully demonstrated awareness of the environment. Therefore, this research was conducted with the aim of measuring student environmental awareness (EA) which integrates Indonesian local culture towards the Sustainable Development Goals (SDGs).  This research design uses survey research. The method used in this study is a quantitative method with purposive sampling technique with a sample of 362 Biology Education students spread throughout Indonesia. This research questionnaire uses a Likert scale of 1-5. Data collection used a questionnaire containing statements totaling 17 items. All indicators as exogenous variables except SDGs as endogenous variables. This study used Structural Equation Modeling (SEM) analysis through the SmartPLS application. The research results show that there is an influence between culturally integrated environmental awareness, awareness of responsibility, and finding solutions to environmental problems against the SDGs. However, the indicator of realizing its role in the environment has no effect on the SDGs, even though the simultaneous influence of all exogenous variables is in the moderate category on the SDGs. The conclusion from this study is that there is a positive influence between culturally integrated environmental awareness, student awareness of responsibility for the environment, and awareness in finding solutions to environmental problems towards the SDGs, but still needs to be improved. Strengthening Indonesian local culture rooted in local wisdom in growing environmental awareness is urgently needed to achieve sustainable development goals. The recommendation in this study is that the use of an active learning approach, for example STEAM, which can stimulate creative problem-solving skills for environmental problems, can be a solution in developing students' environmental awareness.
The Effect of Student Engagement on Boarding School Students' Online Learning Achievement
Authors: Mulyadi  , Omika Hefri Asra
Published: August 2023

Boarding school students must participate in online learning due to the COVID-19 pandemic. Student engagement is an important aspect that must be considered in online learning. This study aims to determine: (1) the level of student engagement of boarding school students, (2) to investigate the effect of simultaneous behavioral engagement, emotional engagement, and cognitive engagement on learning achievement, and (3) to determine the relationship between behavioral, emotional and cognitive engagement with learning achievement, (4) to measure the relative and effective contribution of behavioral, emotional and cognitive engagement on learning achievement. This research is quantitative research with an ex post facto type. 182 boarding school students participated in this study.  The data collection instrument used is the engagement scale from Fredricks & McCloskey. Data processing using descriptive and inferential statistics. The inferential test used is multiple linear regression and Pearson correlation. This study’s results indicate a significant influence between behavioral, emotional, and cognitive engagement on the learning achievement. The influence of these three variables on learning achievement is 46.7%. While the results of the correlation test showed that there is a significant relationship between the variables of behavioral, emotional, and cognitive engagement in learning achievement.
The Effect of Digital Literacy on the Risks of Children Dropping Out of School During the Covid-19 Pandemic
Authors: Muzayyin Afif , Dwini Handayani
Published: August 2023

The Covid-19 pandemic has negative implications for all aspects of life, including aspects of education. It is feared that the transition to a distance learning system (PJJ) that adopts digital technology will reduce students' learning abilities  (learning loss) and potentially increase the risk of dropping out of school. This study aims to study the effect of digital literacy on the risk of dropping out of school for children aged 7-18 years during the Covid-19 pandemic. This study used a quantitative approach that using secondary data of Susenas 2021, Podes 2021, and IP-TIK 2021 publications with 250,921 samples of unit analysis being individuals aged 7-18 years with school status in the academic year (2019/2020) at the elementary to high school levels. Data analysis was performed using descriptive methods and multilevel binary logistic regression. The results of the analysis show that digital literacy as a proxy for digital access (use of mobile phones, computers/laptops, and internet access) has a negative significant effect on the risk of dropping out children of school. Childrens that have higher the digital literacy will have the lower the risk of dropping out children of school. The significant control variables were sex, school level, employment status of the head of household, length of schooling of the head of household, household expenditure quintile, and classification of residence. While the contextual (regional) variable that has a significant effect on the risk of dropping out of school is the information and communication technology development index (IP-TIK)
Effectiveness of Blended Learning Model Development Educational Evaluation Course
Authors: Marzuki Ismail
Published: August 2023

The educational evaluation course is one of the courses in the undergraduate Islamic Religious Education study program. This course teaches theory and practice. The problem in this study is in the form of educational evaluation material with the characteristics of calculating and the mathematical concepts are the main learning difficulties. Educational evaluation learning outcomes have not shown maximum results. By creating a learning material product, this research aims to create a blended learning educational evaluation course and then test the product's effectiveness. The study and development method is the one that is employed. The planning, development, and evaluation phases of the Dick and Carey model are used in this research. Learning design experts, material experts, language experts, and media experts are tested as part of the product testing process. Learning design specialists received an average score of (4.46), followed by material experts (4.44), language experts (4.60), experts in print media (4.82), and experts in non-print media (4.44). (4.58). Following that, 90.91% of one-on-one trials with three pupils were very feasible, followed by 95.28% of small group trials and 96.10% of field trials. After modifications were made based on ideas and advice from experts, the product learning materials are, in conclusion, very practicable to use. The results of the effectiveness test of learning material products revealed that there is a significant difference between the pre-test and value post-test in the use of learning modelsblended learning educational evaluation subject in the learning process. The paired sample t test results obtained a p-value = 0.000, which means that the p-value 0.05. The results of the product effectiveness analysis in the form of student learning outcomes seen from the pre-test and post-test showed an increase, the pre-test total score was 334 and the post-test total score was 616. This shows that the learning outcomes have increased scores so that it can be concluded that the material blended learning in educational evaluation courses is proven to be effective in increasing learning outcomes.
Application of Practicum-Based Learning with Video Media to Improve Basic Learning Outcomes for Class X Students of Vocational High School
Authors: Susilowati
Published: August 2023

This study aims to apply practicum-based learning and video media to improve basic boga learning outcomes in class X students of VHS 6 Surabaya. The subjects of this study were students of class X Tata Boga VHS 6 Surabaya in the 2021/2022 academic year, totaling 36 students. This study used a classroom action research design with two cycles. Data collection techniques were carried out by literature study and observation. The data that has been collected is then analyzed thematically. The results showed that the application of practicum-based learning with video media was able to improve student learning outcomes in the first cycle by 36.1% while the second cycle was 77.8%, which means that there was an increase in the KKM score by 41.7%, this means that the Application of Practicum-Based Learning with video media can improve the learning outcomes of basic boga subjects for class X VHS 6 students by 41.7%. So it can be concluded that video-based practicum can improve student learning outcomes. This method can be an effective alternative to improve student learning outcomes, especially in subjects that require direct practicum.
School Self Evaluation Concepts in The Context of Program Evaluation Mobile School
Authors: J. Lokollo Lambertus , Rudolf Kempa  , Manunay J. Marthen
Published: August 2023

Evaluation of the driving school program is important in proving the success or failure of the program. The stages in the evaluation of driving schools consist of the initial program evaluation stage, the mid-program stage and the final program stage. Driving schools must prepare themselves to face the evaluation process according to the intended stages. Self-evaluation is one of the alternative choices that schools can make to assess the school's self-assessment in achieving the driving school program in order to take steps to change on an ongoing basis in order to achieve the goals of the driving school program as stipulated. This research is a descriptive research carried out using the library research method using content analysis (content analysis). Based on information obtained from the literature related to the concept of school self-evaluation, program evaluation and school performance according to the results of the analysis, school institutions through the concept of self-evaluation with an action research approach can be carried out through the stages of preparation, data collection, formulation of evaluation results, planning and implementing change plans . School self-evaluation with this approach can be carried out repeatedly so that significant changes can be made in order to realize improvements so that the results and impact of the driving school program can be felt.
Virtual Reality-Based Learning about "Animals Recognition" and Its Influence on Students' Understanding
Authors: Sukmawati Fatma , Santosa Eka Budhi , Rejekiningsih Triana
Published: August 2023

The development of Educational technology has experienced a rapid increase which has consciously contributed positively to the motivation for learning achievement, as well as virtual reality media which can bring reality into learning activities. The aim of this research is to produce virtual reality media for learning to know animal’ diversity. This research type is Research and Development with the ADDIE’ developing model which consists 5 steps : 1. Analysis, 2. Design, 3. Development, 4. Impelmentation, 5. Evaluation. The research subject consists of media experts, material experts, teachers, and 27 elementary school second-grade students. Data collection techniques consist of tests and non-tests, with interview guidelines, questionnaires, and test instruments for data analysis tailored to each instrument using average, descriptive, and n-gain. Research results show that Virtual Reality products are declared suitable for use as learning media and are effective in increasing students' understanding of animal introduction for elementary school students. The results of assessments by media experts, material experts, and teachers also showed that these media belong to the category of "appropriate" to be used as learning media. In addition, the media is also included in the "effective" category to help students understand material about animal recognition based on n-gain analysis.
Biochemical Action of Vaccines in Iraqi Patients with COVID-19 Infection
Authors: Jasim Rasha Zuhair
Published: August 2023

The aim of the present study is to compare the biochemical action of the three vaccines taken in Iraq: Pfizer Biontech, AstraZeneca Oxford and Sinopharm based on biochemical parameters. Seventy COVID-19 Iraqi patients ( males and females ) were participated in the present study and classified into 7 groups : Gc :  COVID-19 patients ( without vaccine ) , Gp1: COVID-19 patients took one dose of Pfizer Biontech, Gp2 : COVID-19 patients took two doses of Pfizer Biontech, Ga1 : patients took one dose of AstraZeneca Oxford vaccine , Ga2: patients took two doses of AstraZeneca Oxford vaccine , Gs1 : patients took one dose of Sinopharm vaccine and Gs2: patients took two doses of Sinopharm vaccine. Patients were compared with healthy subjects (without vaccine) as a control group (Gh). The D-dimer level was highly significantly increased in Gc compared with Gh and was highly significantly decreased in Gp1 , Ga1 , Ga2 , significantly decreased in Gp2 and non-significantly decreased in Gs1 and highly significant increased in Gs2 compared with Gc. CRP level was significantly increased in Gc compared with Gh while it was significantly decreased in Gp1, Gp2, Ga1 , Ga2 , Gs1 , Gs2 compared with Gc. IgG and IgM levels were increased in Gc but decreased after taking vaccines ( except Ga2 for IgG and Gp2 for IgM )   The present study submits a novelty to the field of COVID-19 by highlighting the chemical aspects of vaccines used in Iraq
Peran Muhadharah dalam Melatih Kemampuan Komunikasi Siswa
Authors: Ali Ba’ul Chusna Azimah Kusuma Ati;
Published: August 2023

Kemampuan komunikasi siswa merupakan hal yang penting dan harus ditingkatkan. Faktanya, kemampuan komunikasi siswa masih berada di bawa standar yang ditentukan. Hal tersebut nampak ketika guru meminta siswa untuk menjawab pertanyaan, namun siswa tersebut menolak. Tujuan penelitian ini adalah (1) Mendeskripsikan pelaksanaan kegiatan muhadharah dalam melatih kemampuan komunikasi siswa di Madrasah Ibtidaiyah. (2) Mendeskripsikan dampak kegiatan muhadharah terhadap kemampuan komunikasi siswa di Madrasah Ibtidaiyah. Penelitian ini merupakan penelitian  kualitatif dengan metode studi  kasus. Teknik pengumpulan data dalam penelitian ini melalui wawancara,  observasi  dan dokmentasi.  Analisis dalam penelitian ini menggunakan model Milles Huberman. Adapun tahap- tahapnya yaitu tahap reduksi data, penyajian data dan kesimpulan. Hasil  Penelitian  ini  menunjukkan  bahwa telah dilaksanakan kegiatan muhadharah di Madrasah Ibtidaiyah. Ini diawali dengan siswa berpidato di depan teman-temanya. Materi yang dipilih bertema bebas. Kegiatan ini dipandu oleh pembawa acara yang diawali pembacaan ayat suci Al-Qur’an dan bersholawat. Kegiatan dilanjutkan dengan penyampaian pidato dan diakhiri dengan sambutan dan doa oleh guru. Hasil penelitian yang kedua yaitu peningkatan kemampuan komunikasi siswa setelah diadakan kegiatan muhadharah dan  pelatihan dari guru.
Manajemen Kelas Impian dalam Pembelajaran Siswa
Authors: Ali Ba’ul Chusna Apriliyanti Muzayanati;
Published: August 2023

Penelitian ini bertujuan untuk menjelaskan bagaimana pelaksanaan program manajemen kelas impan, dampak manajemen kelas impian, kelebihan dan kekurangan dari program manajemen kelas impian. Diamana manajemen kelas impian merupakan suatu inovasi dari manajemen kelas yang dikembangkan untuk meningkatkan kualitas pendidikan yang dimulai dari ruang kelas. Dalam manajemen ini menekankan aspek fisik termasuk desain yang ada didalamnya seperti pojok baca, pojok bermain, pojok guru dan pojok kebersihan, aspek sosio-emosional, dan juga aspek organisasional. Selain dari ketiga aspek tersebut dalam manajemen kelas impian ini juga menanamkan akan Good Habit. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian studi kasus. Hasil dari penelitian ini antara lain mengenai pelaksanaan manajemen kelas impian dimana dalam pelaksanaannya dilaksanakan oleh wali kelas bekerjasama dengan wali murid, selain itu terdapat dampak dari manajemen kelas impian diantaranya perkembangan siswa baik intelektual maupun sosial, Siswa lebih mudah dikontrol, Kelas menjadi indah dan nyaman, Membentuk good habits. Untuk kelebihan manajemen kelas impian diantaranya memberikan rasa nyaman, siswa lebih mudah berinteraksi antar temanya pada saat pembelajaran, menumbuhkan minat baca, Mengenal permainan-permainan tradisional, Siswa lebih mudah dikontrol. Adapun kekurangan dari kelas impian, diantaranya memerlukan biaya yang cukup besar, ruangan pojok baca tidak digunakan dengan semestinya, kesulitan dalam memebersihkan ruangan apabila penataan meja berdepetan, siswa masih kurang bisa merawat barang-barang yang ada di kelas. Dapat disimpulkan bahwa manajemen kelas impian ini dapat menunjang dalam pembentukan Good Habits dan pembelajaran siswa baik itu secara sosio-emosional, dan organisasional
Penggunaan Metode Resitasi pada Mata Pelajaran PPKn untuk Meningkatkan Hasil Belajar Siswa
Authors: Susanti Rahayu , Anugrah Putri Weni Tria
Published: August 2023

Metode resitasi merupakan metode yang dilakukan dengan menyajikan bahan pelajaran melalui pemberian tugas kepada siswa untuk dipertanggungjawabkan kepada guru. Metode resitasi diyakini dapat menarik minat dan menambah keaktifan siswa. Sehingga mampu meningkatkan hasil belajar siswa. Khususnya pada pelajaran yang mengandung banyak teori seperti PPKn. Penelitian ini bertujuan untuk (1) mengetahui prosedur penggunaan metode resitasi pada mata pelajaran PPKn di kelas VI MI Nurul Iman Pucanganom, (2) mengetahui bahwa penggunaan metode resitasi pada mata pelajaran PPKn dapat meningkatkan hasil belajar siswa kelas VI MI Nurul Iman Pucanganom. Penelitian ini menggunakan metode penelitian tindakan kelas (PTK) yang dikenalkan oleh Kemmis dan Mc Taggart. Penelitian ini dilaksanakan dalam dua siklus. Tiap siklus terdiri dari perencanaan, tindakan, observasi, dan refleksi. Metode pengumpulan data dalam penelitian ini yaitu dokumentasi, observasi, dan tes. Sedangkan metode analisis data yaitu penilaian hasil evaluasi dan ketuntasan klasikal kelas. Hasil penelitian ini menunjukkan bahwa (1) prosedur penggunaan metode resitasi ada tiga fase, yakni fase penugasan, pelaksanaan tugas, dan pertanggungjawaban, (2) Penggunnaan metode resitasi dapat meningkatkan hasil belajar siswa. Pada siklus I persentase ketuntasan hasil belajar siswa mencapai 81%. Sedangkan pada siklus II, persentase ketuntasan mengalami peningkatan hingga 100%. Artinya seluruh siswa kelas VI telah tuntas dalam pencapaian hasil belajar PPKn.
Penerapan Model Pembelajaran Inkuiri Berbantuan Media Peta Tematik untuk Meningkatkan Hasil Belajar Sejarah Kerajaan Islam di Indonesia pada Siswa Kelas V di SDN Jetis Ponorogo
Authors: Fitrianingrum Riska , Hidayati Kurnia
Published: August 2023

Pembelajaran di kelas V SDN Jetis Ponorogo selama ini masih dilakukan secara konvensional. Akibatnya siswa kurang tertarik dan mengalami kejenuhan pada saat kegiatan pembelajaran yang dibuktikan dengan hasil tes yang tuntas dengan presentase (44,44%) sedangkan yang tidak tuntas dengan presentase (55,56%). Penelitian ini bertujuan untuk mengetahui mengetahui hasil belajar dengan menggunakan media peta tematik pada siswa kelas V di SDN Jetis Ponorogo dengan pokok bahasan sejarah kerajaan Islam di Indonesia. Model pembelajaran yang digunakan yaitu model pembelajaran inkuiri dengan berbantuan media peta tematik bagi siswa kelas V di SDN Jetis Ponorogo. Penelitian dilakukan dalam dua siklus yaitu siklus pertama dan siklus kedua. Setiap siklus terdiri dari dua pertemuan dan setiap pertemuan 2 jam pelajaran. Metode penelitian ini dilakukan dengan membentuk kelompok kecil yang terdiri dari 3 siswa kemudian siswa mendapatkan soal yang harus dijawab dan didiskusikan sesuai dengan yang mereka pahami dari kegiatan pendahuluan dan kegiatan inti yang berisi tentang kegiatan mengamati, menanya, berdiskusi dan tanya jawab. Hasil penerapan model pembelajaran inkuiri berbantuan media peta tematik dapat dilihat dari hasil belajar siswa meningkat pada setiap siklusnya, yaitu pada siklus pertama pecapaian ketuntasan sebesar 66,67% dengan nilai rata-rata 72,22 dan pada siklus kedua pencapaian ketuntasan sebesar 88,89% dengan nilai rata-rata 84,44
Implementasi Model Pembelajaran Kontekstual dalam Meningkatkan Proses dan Hasil Belajar pada Mata Pelajaran IPS Kelas 4 MI Ma’arif Polorejo Babadan Ponorogo
Authors: Diza Alief Pangastutik  , Effendi Mukhlison
Published: August 2023

Penelitian ini bertujuan untuk (1) Mengetahui pelaksanaan model pembelajaran kontekstual pada mata pelajaran IPS kelas 4 MI Ma’arif Polorejo, (2) Mengetahui penggunaan model pembelajaran kontekstual dalam meningkatkan proses dan hasil belajar pada mata pelajaran IPS kelas 4 MI Ma’arif Polorejo. Metode penelitian ini menggunakan penelitian tindakan kelas Kemmis&MCTaggart. Penelitian dilakukan dalam dua siklus, yaitu siklus I dan siklus II. Setiap siklusnya terdiri dari perencanaan, pelaksanaan, observasi, dan refleksi. Berdasarkan hasil penelitian menunjukkan bahwa (1) Model pembelajaran kontekstual dapat meningkatkan proses belajar belajar siswa. Hal ini diketahui dari hasil observasi pemahaman konsep belajar siswa. Pada tahap pra siklus persentase pemahaman konsep siswa sebesar 60,74% meningkat pada siklus I menjadi 84,6% kemudian mengalami peningkatan lagi pada siklus II sebesar 86,9%. (2) Model pembelajaran kontekstual dapat meningkatkan hasil belajar siswa. Hal tersebut diketahui dari adanya peningkatan hasil belajar pada setiap siklusnya. Pada tahap pra siklus nilai hasil belajar yang berada dalam kategori tuntas sebesar 19,3% kemudian mengalami peningkatan menjadi 35% pada siklus I, kemudian mengalami peningkatan yang signifikan menjadi 88,5% pada siklus II dari total jumlah siswa di kelas. Maka dengan demikian penerapan atau implementasi model pembelajaran kontekstual terbukti dapat meningkatkan proses dan hasil belajar siswa.
Peningkatan Penguasaan Kosakata Bahasa Arab Menggunakan Metode Mimikri Menghafal Berbantu Media Flashcard
Authors: Uli Fuadiah  , Cahyo Agus Tri
Published: August 2023

Metode mimikri menghafal (mim-mem) merupakan metode yang cocok digunakan, yakni dalam proses menghafal. Selain itu untuk menambah guru juga membutuhkan alat bantu untuk meningkatkan pemahaman siswa terhadap kosakata, maka dipilihlah media kartu flashcard. Yang mana penggunaan media tersebut menjadikan suasana pembelajaran menjadi lebih seru, menarik, dan tidak membuat jenuh siswa saat pembelajaran berlangsung. Kedua komponen pembelajaran tersebut diterapkan di kelas IV Al-Hakim MIN 3 Ponorogo.

       Penelitian ini bertujuan untuk (1) mendiskripsikan penerapan langkah-langkah metode mimikri menghafal berbantu media flashcard untuk meningkatkan penguasaan koasakata dalam pembelajaran bahasa Arab, (2) mendiskripsikan kekurangan dan kelebihan metode mimikri menghafal berbantu media flashcard untuk meningkatkan penguasaan koasakata dalam pembelajaran bahasa Arab. Dalam penelitian kali ini peneliti menerapkan model Penelitian Tindakan Kelas. Penelitian tindakan  kelas adalah proses pemecahan masalah yang dilakukan secara sistematis,  artinya dilakukan secara bertahap melalui beberapa siklus. Sumber data dari siswa kelas IV Al-Hakim MIN 3 Ponorogo Tahun Ajaran 2021/2022.

                Berdasarkan analisis data ditemukan bahwa setelah penerapan langkah-langkah metode mimikri menghafal berbantu media flashcard pemahaman siswa terhadap kosakata meningkat. Dibuktikan dengan meningkatnya nilai rata-rata evaluai siswa dari siklus I sampai siklus III, adapun nilai rata-rata siklus I sangat rendah yaitu 36,19. Nilai rata-rata siklus II naik menjadi 67, dan pada siklus III rata-rata mencapai 80,4 dengan predikat baik sekali. Melihat dari hasil evaluasi tersebut dapat di simpulkan bahwa, penerapan metode mimikri menghafal (mim-mem) mampu meningkatkan penguasaan kosakata bahasa Arab kelas IV di MIN 3 Ponorogo.
PROFIL GAYA BELAJAR SISWA DAN FAKTOR YANG MEMPENGARUHINYA DI KELAS VA MIN 6 PONOROGO
Authors: Khovivah Ananda , Weni Tria Anugrah Putri
Published: August 2023

Penelitian ini bertujuan untuk mendeskripsikan profil gaya belajar visual, auditori, kinestetik siswa, dan faktor yang mempengaruhi gaya belajar siswa pada pembelajaran IPA di kelas VA MIN 6 Ponorogo. Penelitian ini menggunakan pendekatan pendekatan kualitatif. Metode penelitian yang digunakan yaitu deskriptif kualitatif. Hasil penelitian menyatakan bahwa ada 4 siswa yang menunjukkan gaya belajar visual, 4 siswa menunjukkan gaya belajar auditori, dan  9 siswa yang menunjukkan gaya belajar kinestetik. Adapun 4 faktor yang mempengaruhi gaya belajar siswa pada proses pembelajaran IPA di kelas VA; meliputi faktor fisik, faktor emosi, faktor sosiologis, dan faktor lingkungan. Dengan disimpulkan bahwa profil gaya belajar siswa pada pembelajaran IPA di kelas VA MIN 6 Ponorogo ini diketahui ada 3 gaya belajar siswa yaitu visual, auditori, dan kinestetik. Gaya belajar siswa tersebut ternyata dapat dipengaruhi oleh 4 faktor yang terjadi selama pembelajaran IPA di kelas VA yaitu faktor fisik, faktor emosi, faktor sosiologis, dan faktor lingkungan.
Calcium Signaling in MR1-Dependent Antigen Presentation of Mycobacterium tuberculosis.
Authors: Karamooz Elham , Peterson Jessie , Tammen Allison , Soma Shogo , Kim Se-Jin , Lewinsohn David
Published: August 2023

MR1 is a ubiquitously expressed MHC-Ib molecule that presents microbial metabolites to MR1-restricted T cells, but there are differences in the antigen presentation pathway of an intracellular microbe compared to exogenous antigen. We have shown the importance of endosomal trafficking proteins in MR1-dependent presentation of Mycobacterium tuberculosis (Mtb). Two pore channels (TPCs) are endosomal calcium channels that regulate endosomal trafficking. Due to their location on endosomes, we hypothesized that TPCs could be required for MR1-dependent presentation of antigens derived from the intracellular microbe Mtb. We found that TPCs are critical for the presentation of Mtb by MR1; inhibition of TPCs had no effect on MR1 presentation of extracellular (exogenous) antigens, HLA-B presentation, or HLA-II presentation. Finally, we found that the calcium sensitive trafficking protein Synaptotagmin 7 was also key in the presentation of Mtb by MR1. This calcium-dependent endosomal pathway is a novel mechanism by which the immune system can sample intracellular antigens.
Identification of NIBAN2-regulated RUNX2 alternative splicing presents novel strategies antagonizing osteoporosis
Authors: Cai Lin , Zhang Sheng , Yang Zhiqiang , Wei Renxiong , Zhang Yufeng , Chen Zhe , Lv Xuan , Deng Zhouming , Huang Zan , Xie Yuanlong
Published: August 2023

Osteoporosis is characterized by excessive bone resorption and/or defects in bone formation. Identification of factors promoting osteoblast differentiation may provide potential targets for osteoporosis therapy. Through integral analyses of multiple datasets, NIBAN2 was found to be tightly associated with bone formation and osteoporosis. Indeed, NIBAN2 promoted osteoblast differentiation, and conditional Niban2 knockout in osteoblasts caused bone loss and insufficient mineralization in mice. Mechanistically, NIBAN2 interacted with the Hnrnpu-cored spliceosome complex and altered its components to regulate the alternative splicing of Runx2, which ultimately caused an increase in full-length Runx2 but a decrease in exon 6-exclusive Runx2 isoforms to reinforce osteoblast differentiation. Most importantly, NIBAN2 was associated with RUNX2 alternative splicing and correlated with bone loss in osteoporosis patients. Niban2 rescued bone loss in ovariectomy-induced osteoporosis in mice. Thus, our research identifies NIBAN2-regulated RUNX2 alternative splicing as a novel mechanism of osteoblast differentiation that may present new strategies for antagonizing osteoporosis.
Multi-state Markov Model for time to treatment changes for HIV/AIDS patients: A retrospective cohort national datasets, Ethiopia
Authors: Kumsa Tsegaye Hailu , Mulu Andargachew , Beyene Joseph , Asfaw Zeytu Gashaw
Published: August 2023

Background
Virological failure, drug resistance, toxicities, and other issues make it difficult for ART to maintain long-term sustainability. These issues would force a modification in the patient's treatment plan. The aim of the current study was to evaluate the durability first line treatment and reasons of early treatment modification of the patient.
Methods
A retrospective cohort study was conducted from October, 2019 - March, 2020 across all regional states including Addis Ababa and Dire Dawa administrative cities. This study adopted a multi-state Markov model for time to treatment change/switch obtained from 33716 patients. We estimated the transition probability, prediction probabilities and length of stay and factor associated with treatment modification of patients to move from one regimen to another.
Results
Any of the six therapy combinations (14.4%) altered their treatment at least once during the follow-up period for a variety of reasons. Of the patients, 4,834 (13.26%) changed their treatments just once, while 371 (1.1%) changed it more than once. For 38.6% of the time, a treatment change was undertaken due to toxicity, another infection or comorbidity, or another factor, followed by New drugs were then made accessible and other factors 18.3% of the time, a drug was out of supply; 2.6% of those instances involved pregnancy; and 43.1% involved something else. Highly active anti-retroviral therapy (HAART) combinations TDF + 3TC + NVP, d4T + 3TC + NVP, and TDF + 3TC + EFV were high to treatment alterations in all reasons of treatment modifications, with 29.74%, 26.52%, and 19.52% treatment changes, respectively. Early treatment modification or regime change is one of the treatment combinations that include the d4T medication that creates major concern. The likelihood of staying and moving at the the start of s = 0 and 30-month transitions increased, but the likelihood of staying were declined. For this cohort dataset, the presence of opportunistic disease, low body weight, baseline CD4 count, and baseline TB positive were risk factors for therapy adjustment.
Conclusion
Given that the current study took into account a national dataset, it provides a solid basis for ART drug status and management. The patient had a higher likelihood of adjusting their treatment at some point during the follow-up period due to drug toxicity, comorbidity, drug not being available, and other factors, according to the prediction probability once more. Baseline TB positivity, low CD4 count, opportunistic disease, and low body weight were risk factors for therapy adjustment in this cohort dataset.
Pharmacists’ awareness and practices regarding counterfeit medicines in Aksum, Ethiopia
Authors: Asayehegn Amha , Welay Beriha , Kasahun Gebremicheal
Published: August 2023

Background
Pharmacists’ awareness is required to combat the distribution of counterfeit medicines. This is due to, the ultimate goal of treatment outcome might be compromised by the availability of counterfeit medicines, which could have serious consequences of public health. The study was aimed to assess pharmacies’ awareness and practices regarding counterfeit medicines in Aksum, Ethiopia.
Methods
The study was conducted using cross sectional study design between July and August, 2021. A structured data collection tool was used for data collection. Data were analyzed with the help of SPSS Version 23.0.
Results
More than 56% of the respondents had direct experience of drug counterfeiting, and 51.2% of the them didn’t know counterfeit medication reporting system. About 58.5% of the respondents didn’t take any special training on identifying counterfeit drugs. Most of the respondents (73.2%) thought that the current law and regulations of drug counterfeiting are not enough. Approximately 44% of the participants said that expiry date and packaging of the drug are the main distinguishing features of counterfeit medicines.
Conclusion
The most important finding in this study was the pharmacists direct experience of counterfeit medicines, and there is a poor enforcement of law and regulations system in Aksum, Ethiopia. The results point out the need for strengthening the legislation, on regulations system and implementing awareness creation training for pharmacists.
Safe Reinforcement Learning for Learning from Human Demonstrations
Authors: Ramirez Jorge , Yu Wen
Published: August 2023

Learning optimal policies in Reinforcement Learning (RL) can present significant challenges in real-world applications, where it is crucial for agents to demonstrate specific behaviors while ensuring safety and efficiency. For human behavior learning using RL, the matter of safety during the learning process and its subsequent deployment in real-world scenarios has not been adequately addressed. This paper introduces a novel reinforcement learning approach that combines behavior learning with safe exploration in RL, offering a practical and effective method for acquiring specific behaviors while ensuring safety. The proposed algorithm's performance is evaluated in guiding a 2-degree-of-freedom planar robot in its task-space, demonstrating its ability to converge to an optimal policy while strictly adhering to safety constraints. This research has the potential to have a profound impact on various real-world applications, including robotics and virtual assistants.
Optimizing Colorectal Cancer Screening Strategies and Target Populations in Budget-Constrained Regions through Cost-Effectiveness Analysis: A Case from China's East
Authors: LI HAO , Fu Yun , Xu Ao , Zhang Peng , Wang Wei-bing
Published: August 2023

Introduction: Colorectal cancer (CRC) is among the top three cancers globally in terms of morbidity and mortality. For middle-income countries planning to implement regional screening programs, conducting a preliminary assessment to identify individuals at a higher risk of CRC before proceeding with a colonoscopy can be more cost-effective.
Methods: We employed a microsimulation model to assess the impact of various preliminary assessment strategies. Simulations were conducted to identify the optimal age for initiating and ending screening.
Results: The primary data were sourced from the Huzhou screening program, which included 418,805 individuals from 2020 to 2022. All screening strategies were found to be effective, with the cost per incremental Quality-Adjusted Life Year (QALY) being less than $1,026, which is below the minimum standard for upper-middle-income countries. The most effective screening strategy was the annual combined two-sample Immunochemical Fecal Occult Blood Test (i-FOBT) and risk evaluation questionnaires. This approach led to a reduction in CRC incidence and related deaths by 2435 and 1174 cases per 100,000 individuals, respectively, and an increase in Life Years Saved (LYS) by 13903 years and QALYs by 35564 years. The recommended ages to begin and end screening were 48 and 72 years, respectively.
Conclusions: All CRC screening strategies demonstrated effectiveness compared to non-screening, with the annual combined two-sample i-FOBT and risk evaluation questionnaires emerging as the optimal approach. For additional regions, the best screening strategy can be selected based on the health outcomes and costs we have provided.
PCLDA: A cell annotation tool using scRNA-seq data based on simple statistics methods
Authors: Bai Kailun , Xing Li , Shao Xiaojian , Zhang Xuekui
Published: August 2023

With the rise of single-cell transcriptome sequencing technology, more and more studies are focusing on single-cell-based disease diagnosis and treatment. Cell type annotation is the first and most critical step in analyzing single-cell genomic data. Traditional marker-genes-based annotation approaches require a lot of domain knowledge and subjective human decisions, which makes annotation time-consuming and generate inconsistent cell identities. In the past few years, multiple automated cell type identification tools have been developed, leveraging large amounts of accumulated reference cells. All these methods are extensions or revisions of vanilla supervised machine learning methods. However, complex models have four potential disadvantages (1) they may require more model assumptions which may not hold in real-world problems, (2) they may involve many model parameters to be tuned, (3) they may be harder to interpret, (4) they may require more computational resources. In this work, we propose PCLDA, a method based on the simplest statistical models, including principal component analysis and linear discriminant analysis, which do not suffer the problems mentioned above. We show PCLDA’s performance is not inferior to the fancier methods in real data. The key message we promote in this work is to use simple statistics if it can solve the problem, avoiding unnecessary complications.
Hypofractionated Radiotherapy for Refractory or Relapsed Aggressive B-cell Lymphoma in the Rituximab Era
Authors: Huang Cheng , Tang Tian-Lan , Shi Gui-Qing , Qiu Yan-Yan , Lin Yu-Ping , Chen Si-Lin , Zhao Rui-Zhi , Liao Si-Qin , Chen Jin-Hua , Fu Hai-Ying , Liu Jian-Zhi , Xu Ben-Hua , Liu Ting-Bo , Yang Yong
Published: August 2023

Background: Radiotherapy (RT) is an effective and available local treatment for patients with refractory or relapsed (R/R) aggressive B-cell lymphomas. However, the value of hypofractionated RT in this setting has not been confirmed.
Methods: We retrospectively analyzed patients with R/R aggressive B-cell lymphoma who received hypofractionated RT between January 2020 and August 2022 at a single institution. The objective response rate (ORR), overall survival (OS), progression-free survival (PFS) and acute side effects were analyzed.
Results: A total of 30 patients were included. The median dose for residual disease was 36 Gy, at a dose per fraction of 2.3–5 Gy. After RT, the ORR and complete response (CR) rates were 90% and 80%, respectively. With a median follow-up of 10 months (range, 2–27 months), 10 patients (33.3%) experienced disease progression and three died. The 1-year OS and PFS rates for all patients were 81.8% and 66.3%, respectively. The majority (8/10) of post-RT progressions involved out-field relapses. Patients with relapsed diseases, no response to systemic therapy, multiple lesions at the time of RT, and no response to RT were associated with out-field relapses. PFS was associated with response to RT (P=0.001) and numbers of residual sites (P<0.001). No serious non-hematological adverse effects (≥grade 3) associated with RT were reported.
Conclusion: These data suggest that hypofractionated RT was effective and tolerable for patients with R/R aggressive B-cell lymphoma, especially for those that exhibited localized residual disease.
Intrauterine Fetal Death Due to Rupture of Umbilical Vessels: A Rare Case of Furcate Cord Insertion
Authors: Xu Heng , Lu Jia-Ping , Xu Qiu-Lian
Published: August 2023

Furcate cord insertion refers to the separation of umbilical vessels before reaching the placenta, where the branching vessels normally attach at the edge of the placental substance or near the placental membranes. This is an extremely rare abnormal umbilical cord insertion. This paper reported a case of a furcate cord insertion, where the rupture of exposed umbilical vessels led to intrauterine fetal death at full term. Through literature review, we analyzed the prenatal ultrasound characteristics and pregnancy outcomes of furcate cord insertions, with the aim to improve detection rates and reduce the risk of adverse pregnancy outcomes.
Acute distal and symmetrical myositis of uncertain aetiology-a case report and literature review
Authors: Kazi Nahian , Mehmed Melisa , Chen Xiaomei , Asya Omer , Sarma Devraj , Si Pann Ei Hnynn , Abdelhafiz Ahmed H
Published: August 2023

Introduction: Myositis is a clinical condition with a wide spectrum clinical presentation and the classification in the literature is less clear.
Case presentation: We present a case of 33 years old woman with acute history of pain and swelling of both calf muscles. Her investigations confirmed acute bilateral myositis. She responded well to conservative management with full recovery. This case is likely to represent a benign acute childhood myositis (BACM) with an adult onset. Although BACM is common in children up to the age of 12 years, there is an increasing trend of presentation in adults. BACM is a self-limited condition with good prognosis without specific treatment and the diagnosis is largely based on clinical features. Therefore, clinicians should be aware of this type of myositis in adults to avoid unnecessary invasive investigations.
Conclusion: BACM may be changing pattern with an increasing shift of clinical presentation in adults. It is a self-limited condition, which does not need invasive investigations. There is still need for future research to precisely classify the clinical presentation of myositis.