bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementasi Pengamanan Akses Reporting Budget Dealer Menggunakan Algoritma Kriptografi Advanced Encryption Standard (AES) pada Microsoft PowerApps
Authors: Wieko Wieko , Adnan Kemal , Aprillia Eka Putri , Iskandar Dadang Mulyana
Published: June 2024

Keamanan informasi menjadi aspek kritis dalam lingkungan digital, khususnya dalam manajemen dan pertukaran data. Penelitian ini bertujuan untuk mengimplementasikan lapisan keamanan tambahan pada Microsoft Power Apps menggunakan algoritma kriptografi Advanced Encryption Standard (AES) untuk melakukan pengecekan text yang di enkripsi dan hasil enkripsi tersebut akan dikirimkan melalui email, sehingga dapat mengamankan akses reporting budget dealer. Metodologi penelitian melibatkan pemahaman mendalam terhadap konsep AES, analisis kebutuhan keamanan, dan implementasi teknis pada Microsoft Power Apps. Hasil penelitian menunjukkan bahwa integrasi AES pada Microsoft Power Apps mampu meningkatkan tingkat keamanan proses otomatisasi yang melibatkan teks. Enkripsi AES yang diimplementasikan pada level ini memberikan perlindungan terhadap akses yang tidak sah dan mencegah risiko kebocoran informasi.Penerapan ini relevan untuk organisasi yang mengandalkan Microsoft Power Apps dalam alur kerja bisnis mereka, terutama di lingkungan di mana keamanan informasi merupakan prioritas utama. Untuk menjamin perlindungan data reporting agar tidak dapat diakses dengan mudah, maka diperlukan algoritma kriptografi AES, hasil enkripsi tersebut akan dikirimkan melalui email pribadi, sehingga tidak sembarang pengguna yang mendapatkan password keys tersebut.
Kata Kunci: Pengamanan Informasi, Kriptografi, Advanced Encryption Standard (AES), Microsoft Power Apps
Penerapan Kriptografi Aes Pada Fres-Caesas: Perlindungan Pesan Teks Dan Fail Dokumen
Authors: Iskandar Dadang Mulyana , Nadip Muhamad Zaeni , Dinilhaq Nandy , Purnama Anggit
Published: June 2024

Solusi keamanan data telah memimpin kemajuan teknis. Kriptografi dan steganografi adalah dua dari beberapa bidang ilmu yang telah mengembangkan teknik ini untuk melindungi data sensitif. Keamanan data memerlukan seperangkat alat, bukan solusi tunggal. Tujuan utama penelitian ini adalah menggunakan algoritma Advanced Encryption Standard (AES) dan kriptografi untuk mengamankan percakapan teks, fail dokumen, beserta isinya. AES adalah metode kriptografi yang efektif. Data dapat dienkripsi dan didekripsi menggunakan blok ciphertext simetris. Pengguna dapat mengenkripsi SMS, menyimpannya dalam dokumen terenkripsi, mengenkripsi konten dokumen, dan mengompresnya, sesuai dengan analisis data. Untuk menjamin perlindungan data melalui keamanan dan enkripsi, hasil enkripsi fail dokumen disembunyikan dalam sebuah gambar.
Kata kunci : Kriptografi, Advanced Encryption Standard (AES), Pesan Teks, Isi Fail Dokumen, Steganografi.
P63 Expressing Adenocarcinoma of The Prostate Gland, A Rare Neoplasm Which Tends to Pose Diagnostic Dilemma Sometimes: Review and Update
Authors: Kodzo-Grey Venyo Anthony
Published: June 2024

It has been documented that prostate cancer is the world's leading cause of cancer and also the second commonest cancer in men which does tend to pose challenges in its diagnosis. It has been iterated that immunohistochemistry studies utilising tumour markers like high molecular weight cytokeratin, p63 aid in the diagnosis of prostate cancer. It has been known for some time that the absence of immunohistochemistry staining of prostate lesion for p63 and high molecular weight cytokeratin and presence of p504s in the biopsies indicate malignant lesions. Nevertheless, it had also been pointed out as well as documented that some rare cases of adenocarcinoma of prostate variants do demonstrate evidence of the tumour cells exhibiting p63 immunohistochemistry staining and this does pose a diagnostic dilemma that may make the unfamiliar pathologist mis-diagnose such a malignant tumour as a benign prostate lesion. p63-positive adenocarcinoma of the prostate gland is a major diagnostic pitfall. There is a danger of interpreting malignant glands as benign and arriving at a false-negative diagnosis. This can be prevented by the understanding of the pattern of immunohistochemistry staining expression related to this variant of prostate cancer. The major points that favour the diagnosis of carcinoma in these cases include: non-basal p63 staining and negative HWMCK and positive p504s staining. The biological behaviour of this particular rare variant of prostatic carcinoma is not certain and requires to be studied further into more detail. Considering the rarity of p63 expressing prostate cancers and the fact that most clinicians including pathologists, urologists, and oncologists would not have encountered a case of p63 expressing prostate cancer before in order to update all clinicians regarding this rare tumour, the ensuing article has been extensively written and divided into two parts: (A) Overview which has discussed general overview aspects of p63 expressing neoplasms and (B) Miscellaneous Narrations and Discussions from Some Case Reports, Case Series, and Studies Related to Primary p63 Expressing Adenocarcinomas of the Prostate Gland. A high-index of suspicion as well as knowledge of the histopathology examination features as well as immunohistochemistry examination features of this rare tumour is required from all clinicians. Knowledge of the treatment options, biological behaviour as well as outcome following treatment of the tumour has been extensively discussed as updating information. The update has clearly pointed out that further studies are required to determine the role of p63 overexpression in prognostication.
A Novel Mixture of δ-Tocotrienol, Vitamin D3, Resveratrol (NS-3) Significantly Decreases Diabetes Biomarkers Including Inflammatory in People with Type 2 Diabetes
Authors: A Qureshi Asaf
Published: June 2024

Aims: Diabetes mellitus is a metabolic disorder identified by hyperglycemia due to insulin resistance. Impaired serum/plasma fasting glucose, HbA1c, hs-CRP are biomarkers, normally used to determine onset of diabetes. d-Tocotrienol, vitamin D3, and resveratrol (nutritional supplement-NS-3) are potent anticholesterolemic, anti-oxidative and anti-inflammatory agents. We hypothesized that a mixture of d-tocotrienol, vitamin D3, resveratrol (NS-3) will be more effective treatment for reducing diabetes biomarkers as compared to its individual components, in people with type 2 diabetes mellitus (T2DM). Methods: To test our hypothesis, evaluation of NS-3 mixture and its individual components was carried out on diabetes inflammatory biomarkers using peripheral blood mononuclear cells (PBMC) obtained from healthy, normal and people with T2DM. A randomized placebo controlled double-blinded prospective trial of individual components (n = 30/component), and NS-3 trial of people with T2DM (n = 52/group), were given two capsules/d of cellulose/olive oil as placebo, individual components, or NS-3 mixture for 24-weeks. Results: Significant down-regulation (15 - 74; P < 0.002) of gene expression was observed with individual components and NS-3 on diabetes biomarkers (IRS-1, SOD-2, GCKR, ICAM-1, VCAM-1, IL-6, IL-8) in PBMCs of T2DM, and in serum values of fasting glucose (11%), HbA1c (10%), hs-CRP (23%), fasting insulin (9%), HOMA-IR (20%), MDA (20%) of NS-3 treated people with T2DM after 24-weeks. Treatment with individual components showed significant decrease but were less effective than the mixture. RT-PCR analysis of blood RNAs obtained from NS-3 treated people with T2DM for 24-weeks resulted in significant (P < 0.01) down-regulation of gene expression in diabetes biomarkers (IRS-1, SOD-2, GCKR, IGFPB-2) compared to pre-dose values. Conclusions: Present results of in vitro and in vivo studies support our hypothesis that NS-3 mixture is more effective in lowering serum levels of several diabetes biomarkers including inflammatory gene expression markers compared to its individual components in people with T2DM.
Postoperative hypo parathyroid in patient with total thyroidectomy; a multi-center study
Authors: Singhal Vinod Kumar
Published: June 2024

Background: Thyroidectomy complications include nerve damage, hypoparathyroidism, and bleeding. Hypoparathyroidism, marked by reduced parathyroid function, is a common complication, leading to low calcium levels and symptoms like muscle cramps. Incidence rates vary. Surgeons must prioritize parathyroid gland identification and protection during surgery to prevent complications and ensure patient well-being. Aim of the study: The aim of this study has been to evaluate the incidence of hypoparathyroidism and clinical manifestations of hypocalcemia after total thyroidectomy. Methods: This retrospective study, spanning 2020-2022 across four different hospital and teaching institutes in various parts of the world, analyzed 350 patients who underwent thyroid gland surgeries, including 350 total thyroidectomies. Focused on postoperative hypoparathyroidism as an early complication. Inclusion criteria involved age (18-85), complete thyroidectomy, and no prior hypoparathyroidism. Exclusion criteria included coexisting medical conditions and pregnancy. Postoperative hypoparathyroidism diagnosis relied on low serum calcium and parathyroid hormone levels within 24 hours. Result: The study examines the characteristics of a population undergoing thyroid surgeries. Among 144 patients, most are aged 60-65 (41.14%), with 86% females. Total thyroidectomy is standard (87.14%), while 12.86% involve lymphadenectomy. PTH levels below 15.0 pg/ml indicate potential hypoparathyroidism, more prevalent in surgeries with lymphadenectomy. Conclusion: This multicenter study highlights a significant incidence of postoperative hypoparathyroidism after total thyroidectomy and decreased parathyroid hormone (PTH) levels. Early detection and management strategies for postoperative hypoparathyroidism are crucial, with routine monitoring of serum PTH levels within 24 hours post-surgery recommended.
Book Review ‘Cancer and Carcinogenesis’
Authors: Iqbal Uqbah
Published: June 2024

Chromosomes consist of DNA and proteins. Genetic information that regulating cell function resides within the DNA structure and not within proteins. The more chromosomes, the higher the DNA content.
A Matter of Life and Death: State Power and Control of the Body in a Pandemic Era in the Light of Foucault’s Concept of Biopolitics
Authors: Onwuegbuchulam Sunday
Published: June 2024

The advent of COVID-19 pandemic saw the declaration of state of national disaster in South Africa which meant that the country was literally shut down with several restrictions on socio-economic and with it some human bodily activities. The situation has brought into the fore a revived interest in the interrogation of the nexus between state power and control of freedom of citizens. As such, the issue has also brought into focus Foucault’s analysis of power in modern and postmodern societies centring on the concept of biopower/biopolitics. Considering the centrality of citizen’s constitutional right to several civil liberties including right to bodily integrity, there is need to explore the limits of state power in the idea of biopolitics. This essay utilises desktop methods to interrogate state’s power and control of citizen’s bodies in South Africa during and post COVID-19 era. Ultimately, the article is an attempt to contribute to the discourse on how political theorising incorporates human embodiment.
Ethics, Social Interaction and Cyberpsychology: Directors’ Paradox
Authors: Doğanay Meral
Published: June 2024

The main aim of this study is to determine the directors’ senses towards the relation among ethics, social interaction and cyber psychology. Within this scope, the survey form prepared towards this research is applied around six towns of İzmir province between 03/01/2022 -14/02/2022. 192 (n=192) directors about 44 female and 148 men are included in the study. The sense of directors’ ethics and cyber psychology importance is determined to be at high level. As a result of factor analysis findings, cyber psychology from the point of gender; varies in dimension of affective- reactional, mechanic-dynamic interaction, motivational contingency and reflexive approach factors, ethics in terms of education and marital status variables; varies in dimension of executive attitudinal determinism, social interaction, cyberpsychology; varies in dimension of effective- reactional, mechanic-dynamic interaction, motivational contingency and reflexive approach factors, it has been observed that there is no differences in terms of age variables. The finding has been reached that graduate participants put more emphasis on the factors. It has been determined that cyberpsychology influences directors negatively in dimension of affective- reactional, mechanic-dynamic interaction, motivational contingency and reflexive approach and there is a positive linear relationship among ethics, social interaction and cyberpsychology.
Market Risk Analysis with Value at Risk Models using Machine Learning in BIST-30 Banking Index
Authors: Demirdöğen Yavuz
Published: June 2024

Market risk is one of the most critical risks for banks and portfolio managers. According to Basel criteria, Value at Risk (VaR) calculations should be conducted at regular intervals. VaR calculations can be performed using various methods, and the approaches and variables added to the model can vary significantly. Developments in machine learning and deep learning methods have increased the diversity of VaR calculations, enabling the construction of more accurate and complex models.
In this study, a portfolio was created using the stocks of 4 major banks in BIST30 (AKBNK, GARAN, ISCTR, YKBNK) with the help of Monte Carlo simulation and Random Forest. Calculations were made for 126 periods with a 10-day interval using 5 years of daily data. Predictions were made for the last 4 periods using 3 different Value at Risk (VaR) methods (historical, parametric, and Monte Carlo). Independent variables such as VIX (fear index), USD/TL, Gold/TL, and Brent/TL were used. The suitability of the variables was tested with machine learning regularization methods, including Ridge, Lasso, and Elastic Net regression models. Random Forest was again used to measure the impact of independent variables on stocks' weights. For each VaR model, stock weight distributions were determined for the last 4 periods, and the realized VaR results were compared.
As a result of the findings, the parametric VaR method provided the best result for the first period, while the historical VaR method provided the closest result for the other three periods. When comparing the findings with the actual results, it was observed that the findings were more optimistic, and even the closest results did not come within 30% of the actual value. The reason for the difference being greater than expected could be attributed to the fact that the value of bank stocks has been below their value in the last two years and the sharp movements in the stock market in the selected last 4 periods, independent of individual stocks.
escrita-mulher que goza do equívoco
Authors: Barbosa Fabiana Rodrigues , Estevão Ivan Ramos
Published: June 2024

Se “a realidade é abordada com os aparelhos de gozo” (Lacan, 1972-73/2010, p. 127), e se a linguagem é um aparelho de gozo, arriscamos inferir que a linguagem poética é aparelho de gozo nãotodo[1]. Mas o que seria linguagem poética? Qual a função de abordar a realidade com esse aparelho? Se gozar nãotodamente implica evocar o grande Outro barrado, consentir com o impossível de se dizer todo; essa experiência de falha ou perda, articulada à mulher, leva a uma lógica de linguagem poética e furada, propositalmente ou não, que se borda a partir do traquejo com o Real. Para discutir a política da leitura e da escrita em psicanálise comentamos literaturas críticas de sua própria escrita, que desdobram em ato sua arte. A literatura que transcende muros e subordinações convoca o leitor a se implicar com o que passa do Isso pelo escrito. Assim como Lacan convoca cada psicanalista a reinventar a psicanálise tendo em conta o Real, a inconsistência e a feminilidade, não sem os seus outros; evocamos uma leitura-escrita nãotoda d'Ⱥ mulher que goza do equívoco.
 
[1] A escolha pela grafia nãotodo com as duas palavras unidas representa nosso entendimento sobre essa posição ou modalidade de gozo, em que todo fálico e nãotodo fálico são intimamente articulados.
Resenha de Os Nomes-do-Pai
Authors: Delgado de Carvalho Maria Célia
Published: June 2024

Resenha de "Os Nomes-do-Pai", última aula de Jacques Lacan na Capela do Hospital de Saint-Anne em 20 de novembro de 1963, marcando sua saída da Sociedade Francesa de Psicanálise após polêmicas e restrições desde 1959.
Nesse seminário Lacan explora a relação entre angústia, desejo e o conceito de objeto a (causa de desejo).
Lacan também aborda a função do Nome-do-pai e sua relação com o desejo de Deus. Ele explora como o Nome-do-Pai é crucial para lidar com a angústia primordial e conecta essa função com a estruturação do sujeito.
O texto destaca a importância da angústia como um indicador de hiância essencial no ser e examina a ligação entre angústia, objeto a e desejo. Lacan também aborda o papel da transferência na psicanálise, onde a prática analítica é alcançada através do engano.
Em resumo, o artigo discute a aula final de Lacan sobre "Os Nomes-do-Pai", explorando seus enlaçamentos com a angústia, o desejo e o objeto a, causa de desejo.
amor e demônio transferencial
Authors: Pollo Vera
Published: June 2024

O presente texto discorre sobre o amor na teoria e prática analíticas. Primeiramente justifica a importância do tema na atualidade. Em seguida, traz alguns desdobramentos à expressão “o demônio transferencial”. Argumenta as razões de Lacan para distinguir entre a transferência e a repetição e prossegue na elaboração da tríade amor-ódio-ignorância. Comenta algumas conotações lacanianas do amor e conclui na articulação entre amor, castração e inconsciente.
amor e suas veredas
Authors: Delgado de Carvalho Maria Célia
Published: June 2024

O texto discute o amor e suas veredas abordando as paixões do ser, amor, ódio e ignorância, que comparecem na clínica da psicanálise com todas as complicações que decorrem daí.  Para tal fim percorre-se e comenta-se as contribuições de Freud, Lacan e alguns outros sobre o tema.   O que interessa não é falar do amor mas analisar as vertentes desta e das outras paixões do ser lançando mão das inúmeras contribuições pinçadas da obra de Guimarães Rosa  Grande Sertão: Veredas sobre o amor que mais uma vez comprovam como os escritores criativos carregam um saber que pode ir muito além dos desenvolvimentos possíveis pelos conceitos e teorias da psicanálise.
Um sobrevoo também é feito na presença dessas paixões na direção da análise. O texto percorre o caminho trilhado em direção ao desejo através das paixões do ser encaminhando para a possibilidade de um amor mais digno que pode se dar através da análise ou da arte na medida em que ambos os acontecimentos apontam para o real.
Understanding and Balancing the Freedom of Expression and National Security in Realm of Cyberspace: An Overview of Legislative Framework in Pakistan
Authors: Zehra Farheen , Saleem Khan Muhammad , Nawaz Khan Arshad
Published: June 2024

Freedom of speech and expression is an inherent and indelible freedom that gives liberty so that subjects can express their opinions. Article 19 of Pakistan's 1973 Constitution permits certain restrictions concerning state security. The study aims to explore not only the actual significance of free speech under the umbrella of social media and national security but also the rightful utilization of this constitutional right and discern the necessary conditions for ameliorating limitations imposed on it. Descriptive methodology with case studies and content analysis applied and significance lies in the dearth of research on the reasons behind the misuse of freedom of expression in the context of social media. The findings culminate that freedom of expression is the one way to maintain discipline and efficiency in public administration and concluded with significant recommendations for a noticeable balance between national security imperatives and the preservation of free speech.
Media Influence on Youth Health Awareness amidst the COVID-19 Pandemic: A Comprehensive Study on the Role of Public Service Announcements and TV News
Authors: Noor Bhatti Abdul , Ameen Maliha , Nasrullah Izza
Published: June 2024

This study investigates the role of Public Service Announcements (PSAs) and News on TV in creating COVID-19-related health awareness among Pakistani youth. Guided by the agenda-setting theory, the research explores how electronic media coverage adopted media, public, and policy agenda stages in disseminating health precautionary measures during the pandemic outbreak. An online survey was conducted using a questionnaire tool of 32 items with Cronbach's alpha value (α = 0.922). One sample t-test, correlation, and frequency distribution were applied to compare the mean values and to observe the relation between independent and dependent variables of the selected sample of youth (N=436), living in Lahore including both males and females under the age of 18 to 32 years old. Results have shown that government-led PSAs significantly improve youth awareness and knowledge about COVID-19, combating misinformation. Moreover, findings support youth reliance on PSAs and a positive response to vaccination against COVID-19.
Focal motor weakness and recovery following chronic subdural hematoma evacuation
Authors: Nisson Peyton L. , Francis John , Michel Michelot , Patil Surya , Uchikawa Hiroki , Veeravagu Anand , Bonda David
Published: June 2024

OBJECTIVE

The incidence of chronic subdural hematomas (cSDHs) is expected to climb precipitously in the coming decades because of the aging populous. Neurological weakness is one of the most common presenting neurological symptoms of cSDH. Yet, the recovery rates of motor strength recovery are seldom documented, as neurological outcomes have predominantly focused on broader functional assessment scores or mortality. In this study, the authors performed one of the first detailed analyses on functional motor weakness and recovery in patients who underwent cSDH evacuation.

METHODS

Patients who underwent evacuation of a cSDH at a tertiary academic medical center between November 2013 and December 2021 were retrospectively identified using ICD-9 and ICD-10 billing codes. The presence of focal motor weakness was subcategorized by location as upper extremity (UE) or lower extremity (LE). Postoperative improvement, worsening, or resolution of weakness was recorded at the time of discharge. Statistical analysis included univariate and backward stepwise multivariable logistic regression modeling.

RESULTS

A total of 311 patients were included in the analysis. Patients were significantly more likely to experience UE weakness than LE weakness (29% vs 18%, p < 0.001). Forty-one percent (43/104) had both UE and LE weakness present. Risk factors for the development of focal motor weakness at the time of presentation were older age (OR 1.02, p = 0.03), increased cSDH size (OR 1.04, p = 0.02), and the presence of a unilateral cSDH (OR 2.32, p = 0.008). The majority of patients (68%, 71/104) experienced motor strength improvement following cSDH evacuation, with 58% (60/104) having complete resolution of weakness. Multivariable logistic regression analysis revealed that longer symptom duration was associated with lower rates of improvement (OR 0.96, p = 0.024). Older age was also associated with reduced resolution of weakness (OR 0.96, p = 0.02).

CONCLUSIONS

This study represents one of the first in-depth analyses investigating the rates of motor strength weakness and recovery following cSDH evacuation. Nearly two-thirds of all patients had complete resolution of their weakness by the time of discharge, and more than three-quarters had partial improvement. Risk factors for impaired neurological recovery were longer symptom duration prior to treatment and older age.
The association of COVID-19 with increased pediatric ventriculoatrial shunt failures: a national retrospective cohort
Authors: Mahajan Uma V. , Defta Dana , Kaelber David C. , Ahuja Sanjay P. , Rothstein Brian D. , Tomei Krystal L.
Published: June 2024

OBJECTIVE

During the COVID-19 pandemic, the authors’ institution managed ventriculoatrial (VA) shunt complications in 2 teenage patients in close proximity to a symptomatic COVID-19 infection. Systemic thrombotic events are an established complication of COVID-19 infection due to a hypercoagulable state. Thrombotic complications, particularly elevated central venous pressure, can cause VA shunt failure. The true effect of COVID-19 on patients with intravascular devices is currently unknown. In this study, the authors aimed to determine if there was an association between COVID-19 infection and VA shunt failure.

METHODS

TriNetX, an aggregated electronic health record platform, was used to analyze data of more than 13 million US pediatric patients. Two matched cohorts of patients < 18 years of age with a VA shunt were defined. Group 1 (n = 311) had a positive laboratory test for COVID-19 from March 1, 2020, to March 31, 2022. Group 2 (n = 311), a control group, had any medical appointment from March 1, 2020, to March 31, 2022, and never had a positive laboratory test for COVID-19. The authors analyzed outcomes 1 year after testing positive for COVID-19 in group 1, and after the medical appointment in group 2. Outcomes included shunt complications, shunt revisions or replacements, and thromboembolic complications. To protect patient privacy, individual results of fewer than 10 patients are not specified in TriNetX.

RESULTS

Group 1 had a greater odds of mechanical shunt complication than group 2 (20% vs 4%, OR 5.71, 95% CI 3.07–10.62). Group 1 had a greater odds of shunt reoperation than group 2 (11% vs < 3%, OR > 3.7, 95% CI 1.72–7.62). There were 1–10 patients in group 1 (≤ 3% of group 1) who experienced a thromboembolism due to the shunt, compared with no patients in group 2 who had a thromboembolism due to the shunt.

CONCLUSIONS

This analysis demonstrates an association of shunt complications, reoperations, and thromboembolic events in patients with VA shunts following COVID-19 infection.
Relationship between facet joint osteoarthritis and lumbar paraspinal muscle atrophy: a cross-sectional study
Authors: Guven Ali E. , Schönnagel Lukas , Camino-Willhuber Gaston , Chiapparelli Erika , Amoroso Krizia , Zhu Jiaqi , Tani Soji , Caffard Thomas , Arzani Artine , Zadeh Arman T. , Shue Jennifer , Tan Ek Tsoon , Sama Andrew A. , Girardi Federico P. , Cammisa Frank P. , Hughes Alexander P.
Published: June 2024

OBJECTIVE

The paraspinal muscles play an essential role in the stabilization of the lumbar spine. Lumbar paraspinal muscle atrophy has been linked to chronic back pain and degenerative processes within the spinal motion segment. However, the relationship between the different paraspinal muscle groups and facet joint osteoarthritis (FJOA) has not been fully explored.

METHODS

In this cross-sectional study, the authors analyzed adult patients who underwent lumbar spinal surgery between December 2014 and March 2023 for degenerative spinal conditions and had preoperative MRI and CT scans. The fatty infiltration (FI) and functional cross-sectional area (fCSA) of the psoas, erector spinae, and multifidus muscles were assessed on axial T2-weighted MR images at the level of the upper endplate of L4 based on established studies and calculated using custom-made software. Intervertebral disc degeneration at each lumbar level was evaluated using the Pfirrmann grading system. The grades from each level were summed to report the cumulative lumbar Pfirrmann grade. Weishaupt classification (0–3) was used to assess FJOA at all lumbar levels (L1 to S1) on preoperative CT scans. The total lumbar FJOA score was determined by adding the Weishaupt grades of both sides at all 5 levels. Correlation and linear regression analyses were conducted to assess the relationship between FJOA and paraspinal muscle parameters.

RESULTS

A total of 225 patients (49.7% female) with a median age of 61 (IQR 54–70) years and a median BMI of 28.3 (IQR 25.1–33.1) kg/m2 were included. After adjustment for age, sex, BMI, and the cumulative lumbar Pfirrmann grade, only multifidus muscle fCSA (estimate −4.69, 95% CI −6.91 to −2.46; p < 0.001) and FI (estimate 0.64, 95% CI 0.33–0.94; p < 0.001) were independently predicted by the total FJOA score. A similar relation was seen with individual Weishaupt grades of each lumbar level after controlling for age, sex, BMI, and the Pfirrmann grade of the corresponding level.

CONCLUSIONS

Atrophy of the multifidus muscle is significantly associated with FJOA in the lumbar spine. The absence of such correlation for the erector spinae and psoas muscles highlights the unique link between multifidus muscle quality and the degeneration of the spinal motion segment. Further research is necessary to establish the causal link and the clinical implications of these findings.
Improvement of health-related quality of life after closure of spinal CSF leaks in patients with spontaneous intracranial hypotension
Authors: Jesse Christopher Marvin , Schär Ralph T. , Petutschnigg Thomas , Goldberg Johannes , Dobrocky Tomas , Piechowiak Eike Immo , Schankin Christoph J. , Sintonen Harri , Raabe Andreas , Häni Levin
Published: June 2024

OBJECTIVE

Spontaneous intracranial hypotension (SIH) is an important cause of orthostatic headaches caused by spinal CSF leaks. It has a strong negative impact on patients’ socioeconomic status and health-related quality of life (HRQOL). This study aimed to analyze the impact of surgical and endovascular treatments on patients’ HRQOL.

METHODS

The authors conducted a prospective, observational cohort study that included all patients treated for SIH with microsurgery or embolization, depending on the type of CSF leak, at their institution between April 2022 and May 2023. Patients were asked to complete a specifically designed questionnaire, as well as the 15D HRQOL questionnaire, before and 3 months after treatment.

RESULTS

A total of 21 patients (14 female; mean age 51.7 years) were treated in the study period. There were 12 (57%) type 1 leaks, 3 (14%) type 2, and 6 (29%) type 3. While 20 (95.2%) leaks were localized in the thoracic spine, only 1 (4.8%) was found in the lumbar spine. All patients completed the questionnaires. Fifteen (71.4%) patients underwent microsurgery and 6 (28.6%) endovascular embolization. The mean 15D score improved from 0.802 before to 0.889 after treatment (p = 0.013). Compared with an age- and sex-matched general population, HRQOL was significantly impaired in patients with SIH before treatment. After treatment, the authors found no significant difference in the overall HRQOL between patients and the healthy population. Mean headache intensity on a numeric rating scale improved from 8.1 before treatment to 2.3 after treatment (p = 0.003). Patients reported that SIH had a notable impact on their social and working life.

CONCLUSIONS

SIH has a considerable negative impact on HRQOL. Microsurgery or embolization can dramatically improve HRQOL, subjective perception of health, and headache intensity. Therefore, surgical or endovascular treatment should be considered given the improvement observed in HRQOL for patients with SIH.
Aelred z Rievaulx, Pewien wspaniały cud
Authors: Groń Ryszard Stefan , Dutton Marsha L. , Sochań Robert
Published: June 2024

Artykuł ma na celu prezentację tłumaczenia z łaciny kościelnej na język polski wraz z komentarzem do dzieła angielskiego dwunastowiecznego opata z cysterskiego opactwa w Rievaulx, Aelreda, pt. Pewien wspaniały cud. Artykuł został podzielony na trzy części: krótka nota dotycząca życia i twórczości Aelreda (1110-1167), jego spuścizna literacka z uwzględnieniem tłumaczeń na język polski (1); przedstawienie samego utworu z uwzględnieniem jego środowiska, historii, znaczenia i przeznaczenia (2). Pierwsza część jest autorstwa redaktora niniejszego przedsięwzięcia, Ryszarda Gronia; drugą część napisała prof. Marsha L. Dutton, z Uniwersytetu z Ohio w USA, zaproszona do współpracy. Tłumaczenia z łaciny podjął się Robert Sochań, tłumaczenia artykułu prof. Dutton z j. angielskiego dokonał Ryszard Groń. Trzecią część stanowi już polski tekst prezentowanego dzieła Aelreda (3).
Lektura biblijna według Collatio Patrum XIV Jana Kasjana: od erudycji do doświadczania
Authors: Kosmulska Bogna
Published: June 2024

Artykuł prezentuje sposób, w jaki Jan Kasjan, przede wszystkim w Collatio Patrum XIV, radzi sobie z aintelektualizmem (czasem wręcz antyintelektualizmem) niektórych elementów tradycji monastycznej i erudycyjnym charakterem innych. We wprowadzeniu, zarysowane zostały ogólne uwarunkowania piśmienności (literackości) we wczesnym monastycyzmie (z uwzględnieniem świadectw o św. Antonim z Prologu do De doctrina christiana św. Augustyna oraz o abba Teodorze z De institutis coenobiorum Kasjana). W głównej części artykułu przeanalizowana została Collatio XIV, czyli rozmowa z abba Nesterosem o wiedzy duchowej. Obok klasycznych podziałów wiedzy oraz sensów biblijnych, omówione zostały: 1) medium przekazu samych dzieł Kasjana (pisanych, lecz zawierających pewną krytykę pisma, zwłaszcza samej tylko erudycji); 2) uniwersalności kultury pisma; 3) znaczenia pojęcia medytacji, w tym nocnej (niekoniecznie obejmującej jedynie nocną służbę liturgiczną, ale i czas przeznaczony na odpoczynek); 4) dynamiki rozwoju duchowego słuchacza/czytelnika Pisma św., w tym tytułowej trudności, charakterystycznej dla czytelnika młodego i wykształconego – przechodzenia od erudycji do doświadczenia. Głównym wnioskiem artykułu jest, że Kasjan reprezentuje wyważoną linię w kwestii chrześcijańskiego intelektualizmu (gnozy). Choć nie porzuca żadnej z intelektualnych zdobyczy swojego pierwotnego środowiska, którego problemy odzwierciedla Collatio XIV, to formułuje uniwersalną propozycję również dla chrześcijan niewykształconych, którzy mogą być uczestnikami nie tylko chrześcijańskiej praxis, ale również theoria.
Two-Way Trauma in Paul's Letter to the Galatians
Authors: Muir Steven
Published: June 2024

This essay considers the blunt and controversial statement of Paul at the conclusion of Galatians (Gal 6:17). Paul says, “from now on, let no one trouble me, for I bear on my body the marks (stigma, brand or tattoo) of Christ.” Scholars agree that Paul is speaking metaphorically about the scars he received in ministry. By calling his scars “tattoos,” Paul makes an odd sort of honour claim, since tattoos typically were inflicted on low-status slaves in the Roman empire as a mark of ownership and punishment. This essay looks at a common thread of trauma and violence in the letter to the Galatians. Paul works through the traumas he received in two ways. First, he presents a variety of traumatic episodes in the Galatian community – at times, lashing out at his opponents. Second, he deliberately inverts honor and status categories. By boldly claiming to be Christ’s slave Paul asserts his status and finds meaning and vindication in his suffering. This essay takes a more wholistic view of the letter to the Galatians that has previously been done.
Galatians 6:17 and its Reception History: Assessing the Echoes
Authors: Muir Steven
Published: June 2024

This preface engages with the concept of echo as a creative way of generating ideas on how to assess issues in the reception history of a scripture text -- here, Galatians 6:17.
Filoksen z Mabbug, O tym, jak przyjmować Komunię Świętą na rękę
Authors: Szymczak Tomasz
Published: June 2024

Tłumaczenie na język polski krótkiego tekstu Filoksena z Mabbug, O przyjmowaniu Komunii świętej na rękę.
Prace dyplomowe z antyku chrześcijańskiego ukończone w polskich ośrodkach naukowych w latach 2022-2023 (z uzupełnieniem lat wcześniejszych)
Authors: Wysocki Marcin
Published: June 2024

Prace dyplomowe z antyku chrześcijańskiego ukończone w polskich ośrodkach naukowych w latach 2022-2023 (z uzupełnieniem lat wcześniejszych).
Polska bibliografia antyku chrześcijańskiego 2023. Z uzupełnieniami za rok 2022
Authors: Pawlak Adam
Published: June 2024

Corocznie na łamach Vox Patrum jest publikowana bibliografia antyku chrześcijańskiego, która prezentuje dorobek polskich autorów z ubiegłego roku. Bibliografia jest uporządkowana według 13 kategorii tematycznych i według imion autorów antycznych, których dotyczą publikacje.
Effect of Nicotinic Acetylcholine Receptor Ligands on Adhesive Properties of Murine Bone Marrow Granulocytes During Inflammation
Authors: Jirova E. A. , Serov D. A. , Fedorova E. V. , Safronova V. G.
Published: June 2024

The first stage of mature neutrophil granulocytes leaving the bone marrow into the blood and migration to inflammatory center is attachment to vascular endothelium. Disturbance of neutrophil adhesiveness is critical for many diseases with inflammatory components. Endo- and exogenous factors modify the cell ability to adhere via different receptors, including nicotinic acetylcholine receptors (nAChRs). However, the involvement of nAChRs in the regulation of bone marrow (BM) granulocyte adhesion and the role of signaling components in the action of nicotine are poorly understood. In this work the role of different types of nAChRs in the regulation of murine BM granulocyte adhesion during acute inflammation was studied. The study was performed on BM granulocytes of the BALB/c mouse strain using static adhesion assay, confocal microscopy, inhibitor assay, and reverse transcription PCR (RT-PCR). The role of nAChR types was assessed using selective antagonists: 10 nM α-CTX (α7), 10 nM GIC and 5 nM MII (α3β2), 200 nM MII (α3β2 and α7), RgIA and Vc1.1 (α9α10). The number of attached BM granulocytes did not differ between animals with and without inflammation. Nicotine (0.01–100 µM, 30 min) significantly increased cell adhesion in both groups. Toxins (α-CTX, RgIA, Vc1.1) enhanced cell adhesion in both groups, as 200 nM MII did in controls. Fluorescence labelling assays showed expression of α7 and α10 nAChR subunits on cytoplasmic membrane of native BM granulocytes. Using inhibitors, we showed that the effect of nicotine on BM granulocyte adhesion was mediated by heterotrimeric G-proteins, PKC, PI3K, and ROCK both normally and in the presence of inflammation. α7 and α9α10 nAChRs were predominantly involved in regulation of BM granulocyte adhesion, and participation of α3β2 was negligible, possibly due to low expression of α3 subunits. In the regulation of cell adhesion by nicotine, the development of inflammation in the body enhanced the role of α7 nAChRs, which are conventionally expressed on the membrane of BM granulocytes.
The Mechanism of Calcium-Activated Chloride ANO6 Channel Inhibition by CaCCinh-A01
Authors: Kolesnikov D. O. , Grigorieva E. R. , Nomerovskaya M. A. , Reshetin D. S. , Shalygin A. V. , Kaznacheyeva E. V.
Published: June 2024

Proteins of the anoctamine family (ANO) form calcium-activated chloride channels (CaCC) and phospholilpid scramblases. The ANO6 (TMEM16F) protein, which combines the functions of a calcium-dependent scramblase and those of an ion channel, is considered as a molecular target for the treatment of blood clotting disorders, COVID-19-associated pneumonia, neurodegenerative diseases, and other pathologies. CaCCinh-A01, which is a channel blocker of the ANO family, is studied as a potential pharmacological drug. Previously, the effect of this inhibitor was studied using methods representing the integral ion current through the membrane, which does not allow the properties of single channels to be distinguished. Therefore, it remains unknown which characteristics of single channels are sensitive to the blocker: channel open probability, the current amplitude, or the dwelling time of the channel open state. By registration of single ANO6 channels in HEK293 cells, we showed that the action of the inhibitor is due to a decrease in both the current amplitude and the open state dwelling time of single ANO6 channels, which, in turn, leads to a decrease in their open state probability. Thus, we have characterized the mechanism of current reduction through ANO6 channels by the inhibitor CaCCinh A01.
A New Approach to Analyze the State of the Complement System in Patients with COVID-19. Pilot Study
Authors: Avdonin P. P. , Komleva L. А. , Blinova M. S. , Ivanova Е. S. , Kotenko O. N. , Frolova N. F. , Stolyarevich E. S. , Rybakova E. Y. , Avdonin P. V.
Published: June 2024

One of the risk factors for infection caused by SARS-CoV-2 is hyperactivation of the complement system, which can lead to activation and damage to the endothelium, thrombosis and, in some severe cases, the development of multiple organ failure. Using quantitative immunohistochemistry, we studied the opsonization of human umbilical vein endothelial cells (HUVEC) by complement factors C3/C3b when exposed to blood plasma from patients with a confirmed diagnosis of COVID-19 in order to evaluate the possibility of using this approach to study the state of the complement system in COVID-19 ex vivo. For these purposes, FITC-labeled antibodies specific to the C3c domain of factors C3/C3b were used. The integral intensity of the recorded fluorescence and the number of C3/C3b-immunopositive structures were chosen as parameters for assessing the binding of C3/C3b to cells. We have shown that when HUVEC are incubated with plasma from patients, the total number of C3/C3b-immunopositive structures recorded on the membrane of these cells is 5.8 ± 2.8 times (mean ± SD, p 0.001) higher than when exposed to plasma from healthy people. In this case, the integrated fluorescence intensity increased by 6.3 ± 3.2 times (mean ± SD, p ≤ 0.0001) compared to the control. The area of immunopositive structures recorded after exposure to plasma cells from healthy donors and patients with COVID-19 and selected for analysis ranged from 2.2 to 70 μm². Immunopositive particles with an area of 2.2–10.9 μm² after incubation with plasma of COVID-19 patients had a more elongated shape compared to controls. The average number of particles per cell was 0.49 ± 0.06 (mean ± SD, n = 6) in the control, and 2.4 ± 0.4 (mean ± SD, n = 13, p 0.001) during incubation with patient plasma. Analysis of particle area distribution showed that the most pronounced differences in the number of C3/C3b-immunopositive structures compared to the control were observed among large particles. Thus, we showed an increase in the level of opsonization of endothelial cells by complement factors C3/C3b in the presence of plasma from COVID-19 patients in comparison with control plasma. The increase is due to an increase in the number of C3/C3b-immunopositive structures, mostly large ones. We assume that the proposed approach will allow us to study the role of the complement system in damage to vascular endothelial cells in patients with COVID-19 using an ex vivo model, as well as to evaluate the level of complement activation in the plasma of patients and the effectiveness of their treatment.
Influence of Low-Intense Laser Radiation He-Ne Laser on the Composition and Content of Phospholipids and Sterols in the Tissue of Wheat (Тriticum aestivum L.) Callus Tissues
Authors: Dudareva L. V. , Rudikovskaya E. G. , Semenova N. V. , Rudikovskii A. V. , Shmakov V. N.
Published: June 2024

Using chromatography-mass spectrometry and thin-layer chromatography, the effect of irradiation with He-Ne laser light on the composition and content of cell membrane components – phospholipids and sterols – in wheat callus tissues was studied. It was shown that irradiation of callus with laser light at a dose of 3.6 J/cm2 led to significant changes in the content of these components. Thus, the content of phosphatidylinositol increased in irradiated callus by 8 times, phosphatidylethonolamine by 2 times, the content of phosphatidic acid decreased by 20% of the sum of phospholipids. For sterols, it was established that irradiation caused the most significant changes in the content of β-sitosterol, which is dominant in plants (an increase from 1453 ± 170 μg/g of dry weight in the non-irradiated control to 2001 ± 112 μg/g of dry weight 1 h after exposure) and, due to this, in the total content of sterols. Analysis of the results obtained suggests that phospholipids and sterols, primarily those for which regulatory and signaling functions are known, are involved in the response of plant tissue to exposure to low-intensity laser radiation from a He-Ne laser. This participation is realized as a stressful (nonspecific) response to intense radiation.
Different Forms of Superoxide Dismutase from Pea Seedling Roots Differ in Sensitivity to cAMP and Calcium
Authors: Lomovatskaya L. A. , Zaharova O. V. , Goncharova A. M. , Romanenko A. S. , Kishinskaya T. A.
Published: June 2024

It has been established that cyclic adenosine monophosphate (cAMP), a second messenger of the adenylate cyclase signaling system, and Ca2+ are able to dose-dependently modulate the activity of various forms of superoxide dismutase (SOD) in the root cells of pea seedlings of the Rondo variety. The effect of cAMP on SOD activity in pea root cells was studied on intact seedlings by incubating their roots in 50 nM n-dibutyryl-cAMP, a fat-soluble analogue of cAMP, which led to an increase in the intracellular concentration of cAMP. Incubation of similar roots in 800 μM suramin, an inhibitor of transmembrane adenylate cyclase, contributed to a significant decrease in endogenous cAMP levels. In each of these variants, the SOD activity measured in the supernatant obtained from the root homogenate changed. Under the influence of n-dibutyryl-cAMP, the total SOD activity increased to 230%; SOD inhibitors, 3 mM KCN or 3 mM H₂O₂, added to the homogenate, reduced its activity (180 and 190% of the control, respectively). During incubation with suramin, the total activity decreased to 40% of the control value, while with the additional use of SOD inhibitors it decreased to 50–60%. Incubation of seedlings in 400 μM LaCl₃ solution resulted in a decrease in total SOD activity to 73% and in the presence of 3 mM KCN, to 56% of the control, and when 3 mM H₂O₂ was added to the homogenate, to 67%. A similar incubation of seedlings in 1 mM EGTA led to a decrease in total activity by 32%, and the inhibitors had no additional effect. The effect of calcium deficiency or excess on SOD activity was studied in a homogenate of pea seedling roots. When a calcium ion chelator, 100 mM EGTA, was added to the root homogenate, a decrease in the total SOD activity to 81% was observed; when inhibitors (H₂O₂ or KCN) were added, an even greater decrease in SOD activity occurred, up to 65 and 51%, respectively. The addition of 500 nM CaCl2 to the homogenate slightly increased the total SOD activity; KCN reduced SOD activity by approximately 20%, and H₂O₂ had no effect on this indicator. When a higher concentration of CaCl2, 500 μM, was added, the total activity did not change (100%), in the variant with KCN it decreased by 30%, and when H₂O₂ was added it remained almost unchanged. We conclude that cAMP most likely has an indirect effect on SOD activity, while calcium ions probably act directly on the active site of the enzyme molecule; Moreover, each form of SOD differs in sensitivity to calcium.