bluuebunny/crossref_metadata_2025 huggingface dataset:
CORRELATION OF INFLAMMATION WITH STRUCTURAL AND FUNCTIONAL CHANGES IN THE RATS’ PROSTATE GLAND WITH CHRONIC PROSTATITIS UNDER THE EXPOSURE OF CHONDROITIN SULPHATE
Authors: Brechka Nataliia , Kozar Valentina , Korenieva Yeugenia , Dolzhykova Olena , Bondarenko Vоlodymyr , Tkachenko Nataliia , Borozenets Viktoriia , Protsenko Olena , Zalubovskaya Elena
Published: March 2022

According to statistics, about 10 % of urological patients in Ukraine have diagnose as well chronic prostatitis/chronic pelvic pain syndrome, or non-bacterial chronic prostatitis. The etiology and pathogenesis continue to be substantially uncertain, but inflammation is one of the triggers that also involves connective tissue. The aim of the work was to evaluate and compare changes of inflammation markers and histological structure of prostate tissue in rats with experimental chronic prostatitis under conditions of Chondroitin sulfate use.
Material and Methods. Non-bacterial prostatitis was caused by local irrigation of the previously exposed surgical access to isthmus and ventral parts of the prostate for 5 seconds by an applicator for the wart removal Wartner®, the wounded surface was sewed in afterwards. Non-bacterial prostatitis was caused by local irrigation of the previously exposed surgical access to isthmus and ventral parts of the prostate for 5 seconds by an applicator for the wart removal Wartner®, the wounded surface was sewed in afterwards. To assess the anti-inflammatory and prostatoprotective properties, we used the introduction of the substance Chondroitin sulfate (manufactured by Sigma, USA) and the reference drug Prostoplant forte (manufactured by Schwabe, Germany). The drugs were administered three days before the simulation of cryotraumatic prostatitis and within 11 days after cryotrauma. The state of inflammation was assessed by the level of C-reactive protein, the number of leukocytes, the erythrocyte sedimentation rate in the blood, and during pharmacological correction. The state of the connective tissue was assessed according to the results of histological examination of the prostate.
The results of the laboratory and histological studies in the conditions of simulating prostatopathy have been shown that markers of inflammation of the blood and prostate tissue have parallel unidirectional changes. Both drugs have a distinct anti-inflammatory effect and they are able to protect prostate tissue from destructive changes resulting from inflammation. The effectiveness of Chondroitin sulfate did not concede to the comparison drug Prostoplant forte, and was even partly more effective in normalizing the concentration of C-reactive protein C-reactive protein and reconstruction of prostate tissue. Conclusion. These results indicate that the use of a combination of prostatoprotectors and drugs capable of affecting the metabolism and reconstruction of connective tissue is promising for the treatment of prostatitis.
CIRCADIAN DISRUPTION AS A FACTOR OF IMPAIRED ADAPTIVE T-CELL IMMUNITY RESPONSE
Authors: Gevorkyan Aida , Ippolitov Danyyl , Бочарова Тетяна
Published: March 2022

The study was carried out with the aim to evaluate the effects of continuous lightning (CL) and subsequent circadian rhythm disruption on CD4+/CD8+ populations of adaptive cell immunity. For further understanding of underlying processes that affect CD4+/CD8+ proliferation and differentiation, the expression levels of CD3+ and CD95+ cell receptors were evaluated. Chinchilla rabbits were exposed to shift work simulation - 24 hours of CL. We organized 5 time-related groups: 2, 4, 6, 12 months of CL respectively. The 5th group – corresponding control. Thymus derived slides were examined using immunofluorescence assay. A decrease in the expression of CD3+ and CD8+ and an increase in the expression of CD4+ lymphocytes, which was accompanied by an increase in the ratio of CD4+/CD8+ were found after 2 months of the experiment. After 4 and 6 months of CL, there was an increase in CD3+ expression and a decrease in CD4+ and CD8+ expression. The lowest levels of CD3+, CD4+ and CD8+ were recorded after 12 months of the experiment, which is a manifestation of significant immunosuppression due to premature aging of the thymus. The level of CD95+ lymphocytes was higher in the group after 12 months of CL, indicating the activation of apoptosis in thymocytes caused by circadian rhythms disruption under the influence of chronic light stress.
THE IMPACT OF SUCCINATE DERIVATIVE PHENSUCCINAL ON MITOCHONDRIAL FUNCTION AND REDOX STATUS IN THE HEART OF RATS WITH TYPE 2 DIABETES
Authors: Gorbenko Nataliia , Borikov Oleksii , Ivanova Olha , Kiprych Tetiana , Taran Katerina
Published: March 2022

Dysfunction of cardiac mitochondria appears to play a substantial role in cardiomyopathy and is a promising therapeutic target for many cardiovascular diseases. Persistent hyperglycaemia and hyperlipidemia are believed to be the main causes of increased oxidative stress, mitochondrial dysfunctions, fibrosis and apoptosis of cardiomyocytes in diabetes. We have previously shown that the low-toxic succinate derivative – Phensuccinal (beta-phenylethylamide-2 hydroxy-succinanylic acid, Phe) possesses antioxidant and anti-inflammatory properties. The aim of this study was to assess the effects of Phe on the mitochondrial function and oxidative status in the heart of rats with T2DM.
Materials and Methods. T2DM was induced in Wistar rats by a high-caloric diet during 14 weeks combined with intraperitoneal injections of 25 mg/kg streptozotocin twice per week. All diabetic animals were divided into two groups: treated with vehicle or with Phe (in dose 50 mg/kg/day) for four weeks after diabetes induction. Redox status of rats’ heart mitochondria was estimated by determination of reactive oxygen species (ROS) production, GSH level and activity of antioxidant enzymes (Mn-superoxide dismutase, glutathione peroxidase and glutathione reductase). Mitochondrial function was determined by activity of aconitase, succinate dehydrogenase and cytochrome C oxidase in rats’ cardiomyocytes.  
Results. It was established that Phe inhibited oxidative stress in isolated heart mitochondria of rats with T2DM, which was confirmed by decreasing ROS production and increasing GSH level compared to diabetic rats. The use of Phe led to a normalization of antioxidant enzymes (Mn-superoxide dismutase and glutathione peroxidase) activity in the heart of diabetic rats. In addition, Phe improved metabolic activity of the heart mitochondria activating aconitase and succinate dehydrogenase in cardiomyocytes. We can suggest that Phe ameliorate mitochondrial dysfunction decreasing oxidative stress and preventing deficiency in complex II of ETC in the heart of rats with type 2 diabetes.
Conclusion. The data of the present study confirmed the positive effect of Phe on redox homeostasis and functional state of the heart mitochondria in diabetic rats. We suggest that the use of Phe may contribute to the amelioration of cardiovascular risk in type 2 diabetes
EFFECT OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND PARACETAMOL ON THE FUNCTIONAL STATE OF THE THYROID GLAND IN EXPERIMENTAL OSTEOARTHRITIS WITH HYPOTHYROIDISM
Authors: Nosivets Dmitriy , Opryshko Valentina , Shevchenko Tetyana
Published: March 2022

The question of the effect of NSAIDs on the functional state of the thyroid gland arises due to the existence of conflicting studies on the various effects of drugs, in particular NSAIDs on thyroid hormones in the serum. It is known that drugs can affect the hormonal activity of the thyroid gland in various ways, in particular through the induction of cytochromes, direct influence on the synthesis and secretion of hormones or their metabolism, clearance and uptake by tissues, antagonism with transport proteins. The aim of the study was to investigate the effects of NSAIDs and paracetamol on the functional state of the thyroid gland in osteoarthritis with hypothyroidism.
The study was performed on 80 nonlinear white rats with reconstituted osteoarthritis and hypothyroidism. To address the question posed about the effect of NSAIDs and paracetamol on the functional state of the thyroid gland, which was determined by the level of hormones TSH, T3 and T4, each of the studied drugs was administered in two doses. Doses were chosen based on calculations based on average and maximum human doses, using a species sensitivity factor, and taking into account data from the literature. Interpretation of the results obtained was based on the known fact that clinical laboratory diagnosis of hypothyroidism is characterized by increased concentration of TSH and decreased content of free T4, while the concentration of free T3 remains within the normal range or sometimes decreases.
The conducted study revealed that analgesic drugs exhibit a variety of effects on thyroid function in conditions of comorbid pathology, which depends on both the drug itself and its dose.
The authors have identified drugs that can adversely affect hormone concentration in a dose-dependent manner. Thus, ibuprofen (7 mg/kg), meloxicam (12 mg/kg) and nimesulide (100 mg/kg) reduced the TSH level and increased the serum T4 level in rats, which aggravated hypothyroidism. It was proved that pharmacotherapy of osteoarthritis against the background of hypothyroidism should take into account the effect of analgesics on the hormones of TSH, T3 and T4, which should be kept in mind while correcting the functional activity of the thyroid gland.
Family Support Toward Adherence and Glycemic Control of Type 2 Diabetes Patient: A Systematic Review
Authors: Yusra Aini , Waluyo Agung
Published: March 2022

The increase in diabetes epidemic, particularly type 2 diabetes in adults has occurred in the past three decades. This phenomenon happened especially in the developing countries. Patients' compliance is required in order to properly adopt self-care management and assist prevent consequences from persistent hyperglycaemia. Families can help patients by providing care, which has a positive impact on their adherence. This study intends to investigate the association between family support and type 2 diabetes patients' adherence to diabetes therapy in order to improve glycaemic control.
Materials and methods. Three databases of Pubmed, Ebscho and Wiley were used to obtain relevant articles. Article searches using key words “type 2 diabetes”, “family support”, “adherence” and “compliance”. The PRISMA method and PICO concept were used to determine which study was worth to be reviewed, and it was obtained 15 selected studies to be identified in the period from January 2008 – December 2018. The studies discuss about the forms of family support and their impact on the adherence and glycaemic control of the patients. The designs of the 15 studies were 2 qualitative studies, 8 quasi experiments, 4 mixed-method studies and 1 systematic review.
Conclusion. The findings revealed that family support enhanced the health of patients with type 2 diabetes mellitus in a comprehensive study. Higher levels of support remained a key feature in the self-care management's success.
A Method to Deliver Automated and Tailored Intervention Content to Dyads: Longitudinal Clinical Trial (Preprint)
Authors: Miller Hailey , Voils Corrine , Cronin Kate , Jeanes Elizabeth , Hawley Jeffrey , Porter Laura , Adler Rachel , Sharp Whitney , Pabich Samantha , Gavin Kara , Lewis Megan , Johnson Heather , Yancy Jr William , Gray Kristen , Shaw Ryan
Published: March 2022

BACKGROUND

The use of digital technologies and software allows for new opportunities to communicate and engage with research participants over time. When software is coupled with automation, we can engage with research participants in a reliable and affordable manner. Research Electronic Data Capture (REDCap), a browser-based software, has the capability to send automated text messages, yet has not been previously utilized to automate tailored intervention content to dyads in a longitudinal partner-assisted behavioral weight management intervention.

OBJECTIVE

To describe the development and use of two REDCap databases to deliver automated intervention content and communication to participants and their partners (dyads) in a longitudinal weight management trial, Partner2Lose

METHODS

We used REDCap to automate the delivery of tailored intervention content and communication to index participants and their partners in a two-arm, 24-month weight management trial, Partner2Lose. Two databases were developed to correspond to two study phases: one for weight loss initiation and one for weight loss maintenance and reminders. The weight loss initiation database was programmed to send participants (both arms) and their partners (partner-assisted arm) tailored text messages during months 1-6 of the intervention to reinforce class content and support goal achievement. The weight maintenenance and reminder database was programmed to send maintenance-related text messages to each participant (both arms) and their partners (partner-assisted arm) in months 7-18. It was also programmed to send text messages to all participants and partners over the course of the 24-month trial to remind them of group classes, dietary recall and physical activity tracking for assessments, and measurement visits.

RESULTS

Five cohorts, comprising 231 couples, were consented and randomized in the Partner2Lose trial. The databases will send 53,518 automated, tailored text messages during the trial, significantly reducing the need for staff to send and manage intervention content over 24 months. The cost of text messaging will be approximately $450. Thus far, there is a 0.004% error rate in text message delivery.

CONCLUSIONS

Our trial automated the delivery of tailored intervention content and communication using REDCap. The approach described provides a framework that can be used in future behavioral health interventions to create an accessible, reliable, and affordable method for intervention delivery and engagement.

CLINICALTRIAL

Clinical trials identifier: NCT 03801174
Development of Virtual Training Platform for Tandem Cold Rolling Mill Using Data Science and Digital Twin Technology
Authors: Usmani Najmul Islam , Panigrahi Rajaram , Mishra Susanta Kumar , Dalal Achinta Kumar , Juyal Rakesh , Meshram Dhiraj , Gaurav Kumar , Prakash Ravi
Published: March 2022

Abstract: An attempt has been made to develop Virtual Training Platform for Pickling Line Tandem Cold Mill (PLTCM) intended to deliver faster and enhanced learning experience of the process operator by leveraging Advanced Data Modelling, Data Science and Digital Twin Technology. Virtual Training Platform has modules for virtual tour of the plant, setup simulation, real-time rolling simulation, performance evaluation. Rolling Simulation has ANN based Automatic gauge control model and DNN based shape prediction model. Platform also comprises of a Natural Language Processing based chatbot for online query related to process line. Keywords: tandem cold Mill; Deep Neural Network (DNN); Virtual tour; Automatic Gauge Control (AGC), shape Control; chatbot
Waste Management and Recycling to Recover Metals without Producing Harmful By-Products
Authors: Rathod Tarun
Published: March 2022

Abstract: Given the volume of e-waste generated and the content of both dangerous and valuable materials in it, electronic garbage, or e-waste, is both an expanding concern and a growing commercial opportunity. Lack of technical skills, insufficient infrastructure, insufficient financial assistance, and inactive community involvement are all factors that contribute to the difficulty of electronic waste management. This paper presents a comprehensive summary of the issues connected with incorrect E-waste recycling processes, as well as measures to mitigate their harmful impacts on human health and the environment. Inventory of used electronic items, which may be generated by building an environmentally friendly recycling regulation system, is essential for proper e-waste management. In both developed and developing countries, approaches have been created to aid in the implementation of good waste management. Systematic waste management techniques, together with best practices, are projected to help developing countries maintain a sustainable and resilient environment while reducing negative consequences. The electronics industry is the largest and fastest-growing manufacturing sector on the planet. However, rising electronic device sales, quick technological obsolescence, fashion, style, and status changes have resulted in e-waste, also known as e-waste. If waste is not properly disposed of, it includes many toxic components that can harm the environment and human health. As garbage is generated and disposed of in a globalized world, waste concerns are of global importance. Trash management is becoming increasingly significant in India, not just for the country's own rubbish production, but also for the landfilling of waste from industrialized countries. This is due to India's lack of suitable disposal and recycling infrastructure and methods. The goal is to come up with creative and cost-effective ways to detoxify waste-contaminated habitats, make them safe for human habitation and consumption, and safeguard ecosystem services. Distinct categories of E-waste, different classifications of E-hazardous waste components, E-waste treatment methods, and more ecologically friendly and profitable methods for decontaminating E-waste from soil water habitats are discussed in this study. Innovative bioremediation technology, the waste management problem that India poses, and the idea of a formal trash recycling system in India. Keywords: E-waste management. Recycling. Electronic waste. Hazardous components. Formal methods Heavy metals. Cost-effective solution. Developmental toxicology
Numerical and Analytical Investigation of Forming Limit Diagram of SS316L foil
Authors: Godage Omkar , Kakandikar Ganesh M
Published: March 2022

Abstract: In process of sheet metal forming, forming limit is characterised by the start of cracking, wrinkling, necking and it is crucial to know the limit up to which the sheet metal can be formed. Forming limit diagram (FLD) gives a brief idea about major and minor strains along with forming limit curves. The mainly three ways for plotting of FLD as given analytical, numerical, and experimental. The research work presents micro-forming investigations on an stainless steel sheet of 50 microns, to plot FLD, using the limit dome height test in accordance with to ASTM E2218-02 standard. Forming limit diagram (FLD) offers a suitable and useful tool to predict the forming behaviour of the sheet metals. This paper is concentrated on the plotting of FLD for stainless steel(SS-316L). Numerical and analytical approach are used to develop forming limit diagram of ultra thin SS316L metal foil. Keywords: Sheet metal, Micro forming, Forming Limit Diagram, Analytical, Numerical
Estimation Based on Optimally Selected Single Order Statistic in Pareto: Rayleigh Distribution
Authors: Ravikumar M. S. , Rao I. Narasimha , Kantam R. R. L.
Published: March 2022

Abstract: A special case of the well known T – X family of distributions proposed by Ayman Alzaatreh et al. (2012) called Pareto – Rayleigh (P – R) distribution is considered. Its scale parameter is estimated using a single order statistic in small samples. Optimal criterion for the choice of single order statistic in a given small sample is worked out. Comparison is made with the corresponding optimal choice of single order statistic with respect to the criterion of asymptotic variance. The results are extended to estimate parametric functions like reliability and hazard rate. Keywords: T-X family, Pareto-Rayleigh distribution, order statistics, optimal estimation, asymptotic variance.
Plastic Pollution
Authors: Wagh Ameya , Bhavsar Falguni , Shinde Raj
Published: March 2022

Abstract: Plastic pollution is one of the fastest growing environmental challenges of our time. Since the 1960’s, various concerns were raised regarding plastic waste generation (Plastic pollution) around the globe. Everyday tons of plastic waste is generated in various cities across the world. Since the 1950’s close to half of the plastic is ended up in landfills or dumped in the wild which is one of the most common ways of disposing plastics, and only 9% of plastic has been adequately recycled. It is also estimated that around 4 to12 million metric tons of plastic waste ends up in the oceans. This points out that this is a collective failure of all human kind to find a feasible solution for the plastic disposal.
Gesture Recognition-based AI Virtual Mouse
Authors: Shukla Akhilesh , Katiyar Dr. Devesh , Goel Mr. Gaurav
Published: March 2022

Abstract: An amazing invention in Computer Technology is the mouse. Nowadays, A Bluetooth mouse or wireless mouse still has some limitations as it requires a battery for power and a dongle to connect to a PC. This issue may be solved in the proposed gesture-based AI virtual mouse by capturing hand motions and revealing hand tips with a webcam or integrated camera, as gestures are a powerful means of communication between people. Based on hand gestures, the computer can be almost controlled and can perform right- clicking, left-clicking, scrolling and computer cursor functions without using the physical mouse. Therefore, the proposed system will help avoid the dissemination of COVID19 by hindering the deadly intervention and confidence of bias in the control of the computer. Keywords: AI, Virtual Mouse, OpenCV, Computer Vision, Mediapipe
Signature Verification Using Neural Network
Authors: Priyadarshini K. , A Nisanth Sai. , Krishna P. Sai , Choubey Dr. Shruti Bhargava
Published: March 2022

Abstract: In this paper we are about to present a latest improved off-line signature verification system using global and texture features of the signatures. This version is based on the technique that applies pre-processing on the signature to get a binary image and then calculate the global and features points from it and than maintain a updated vector. All calculations are done on the basis of these feature points. The feature vector obtained from the global and texture features is used to compare with the feature vector of incoming testing signature. Based on the values obtained, the network will decide the appropriateness of the signature. The suggested scheme discriminates between original and the forged signatures using artificial neural network (ANN) for training and verification of signatures. The method takes care of simple and the random forgeries and the skilled forgeries are also eliminated in greater extent. The objective of the work is to reduce two vital parameters, False Acceptance Rate (FAR) and the False Rejection Rate (FRR). So the results are expressed in terms of FAR and FRR and subsequently comparative analysis has been made with standard existing techniques. Results obtained by our proposed algorithm are more efficient than most of the existing techniques.
Application of Third Order Taylor Method to Population Equations
Authors: Sundaram Arunachalam
Published: March 2022

Abstract: In this paper, we implement the third order Taylor method for three different population initial value problems. The Taylor method is derived from the Taylor series expansion. The Taylor series method is one of the earliest methods for the approximate solution for initial value problems for ordinary differential equations. Taylor method is implemented to linear population equation, non-linear population equation and non-linear population equation with an oscillation. The method of solving three initial value problems is implemented using Python Programming. Keywords: Differential equation, Taylor method, Population equation, Non-linear population equation, Oscillation, Python.
Possibilities of Correcting Iron Deficiency Anemia Caused by Chronic Kidney Disease Complicated by Chronic Heart Failure
Authors: Najmiddinovich Temirov Nuriddin , Ergashevich Shomurodov Kodir , Abdikhalilovna Amerova Dilafruz
Published: March 2022

Abstract: The study evaluated the effectiveness of intravenous administration of iron saccharate (Sufer® preparation) for 2 weeks in 12 patients with iron deficiency anemia due to chronic kidney disease, who were examined and treated in the nephrology department of the Dnepropetrovsk Regional Clinical Hospital named after I.I. Mechnikov. Inclusion of iron (III) hydroxide sucrose complex into therapy led to a significant increase in hemoglobin, ferritin, iron in blood plasma, and contributed to a decrease in creatinine levels (p<0.01). The increase in hemoglobin level began already from the 5th day of treatment. After 2 weeks, the hemoglobin level increased by 13% (p<0.01). When using the drug, there were no significant side effects that required a change in its daily dose or discontinuation of treatment. The therapeutic effect and good tolerance of iron (III) sucrose complex hydroxide allow us to recommend it as the drug of choice for iron deficiency anemia in patients with chronic kidney disease. Keywords: chronic kidney disease, iron deficiency anemia, iron saccharate, Sufer®.
Peran Benyamin Suaeb dalam Modernisasi Kesenian Gambang Kromong di Jakarta Tahun 1970 – 1975
Authors: Amal Naufal Faris , Gunawan Rudy , Qodariah Lelly
Published: March 2022

Penelitian ini bertujuan untuk untuk mengetahui pengaruh Benyamin Suaeb dalam kesenian musik Gambang Kromong dari budaya tradisional menjadi budaya populer. Metode penelitian yang digunakan pada penelitian ini adalah metode penelitian sejarah yang terdiri dari tahapan heuristik, verifikasi, interpretasi dan historiografi. Berdasarkan hasil penelitian, peran Benyamin Suaeb dalam musik gambang kromong modern dalam lantunan nada maupun lirik, dengan memberikan sentuhan baru berupa penambahan-penambahan alat musik seperti gitar, bass, seksofone dalam musik gambang kromong modern dengan syair-syair di setiap lagunya yang lebih sering dikaitkan dengan orang kecil, adanya kesusahan hidup dan ketidakadilan. Benyamin berhasil menampilkan diri sebagai seniman yang mampu melihat sisi manusiawi dari kehidupan orang-orang Jakarta. Benyamin mempunyai cara tersendiri dalam mengangkat persoalan dengan kalimat yang spontan dan jenaka.
Keberadaan Komunitas Masyarakat Adat Karuhun Urang (AKUR) dalam Pelestarian Budaya Sunda Wiwitan: Studi Kasus di Cigugur, Kuningan
Authors: Wulandari Nopiyanti , Gunawan Rudy , Bandarsyah Desvian
Published: March 2022

Penelitian ini bertujuan untuk mendeskripsikan keberadaan komunitas masyarakat adat Karuhun Urang dalam Pelestarian Budaya Sunda Wiwitan di Cigugur Kuningan, dan bagaimana interaksi sosial yang terjalin antara komunitas AKUR dan masyarakat Cigugur. Penelitian ini merupakan penelitian deskriptif kualitatif. Subyek penelitian ini adalah pengelola komunitas di wilayah Cigugur anggota komunitas dan masyarakat sekita komunitas. Sebagai informan kunci adalah pengelola komunitas di wilayah Cigugur. Pengumpulan data dilakukan dengan menggunakan metode wawancara, observasi, dan dokumentasi. Peneliti merupakan instrument utama dalam penelitian dengan dibantu pedoman wawancara, pedoman observasi dan pedoman dokumentasi. Teknik yang digunakan dalam analisis data adalah reduksi data, menampilkan data, dan verifikasi data. Hasil penelitian menunjukkan bahwa : berbagai upaya yang dilakukan oleh masyarakat AKUR dalam melestarikan budaya Sunda wiwitan sehingga budaya sunda dapat di ketahui oleh masyarakat, dan masyarakat ikut berpartisifasi dalam melestarikan budaya lokalnya, wujud dari upaya untuk melestarikan budaya tersebut diwujudkan dalam rangkaian upacara Seren Taun. Kegiatan tersebut dapat terwujud dengan adanya kerjasama dari berbagai pihak, yaitu dari pemerintah kota Kuningan, kelurahan Cigugur, Komunitas AKUR dan masyarakat Cigugur.
EXPLORING THE RELATIONSHIPS BETWEEN DEMAND ATTITUDES AND THE SUPPLY AMOUNT IN CONSUMER-DRIVEN SUPPLY CHAIN FOR FMCG
Authors: Galkin Andrii , Yemchenko Iryna , Lysa Svitlana , Tarasiuk Mykhailo , Chortok Yulija , Khvesyk Yuliia
Published: March 2022

The development of the retail market in Ukraine and in the world requires the improvement of methods and models of effective interaction of supply and demand in the supply chain for the purchase of goods of daily demand. The article presents an integrated method for demand driven supply chain management at the distribution stage for FMCG (Fast moving consumer goods). The influence of end-consumers and demand on the functioning of the logistics system has been investigated. The approach is based on systems analysis, which shows the interdependence of the parameters of the logistics system and the consumption system. The approach takes into account the parameters of consumers and the logistics system and is an extension of knowledge on the use of consumer-oriented approach in the logistics system (demand-driven supply chain). The obtained results can be used in planning and organizing a modern demand driven supply chain.
THE NEXUS BETWEEN ORGANISATIONAL CAPABILITIES, ORGANISATIONAL READINESS AND REVERSE SUPPLY CHAIN ADOPTION
Authors: Alsmairat Mohammad
Published: March 2022

Successful Reverse Supply Chain Adoption (RSC) adoption requires a clear identification and understanding of Organizational Capabilities, assets, and resources internally and externally. Towards this end, this research assesses the nexus between organisational capabilities and RSC Adoption with a focus on the mediation role of organisational readiness. A survey method was used to achieve the research objectives. Different manager levels from the Jordanian industrial sector were selected by using a convenient sample technique. SMART PLS 3 was used to conduct Structural Equation Modelling (SEM). The outcomes represent a significant influence for internal organisational capabilities on the RSC adoption. As a mediation result, organisational readiness has a mediation role between internal organisational capabilities and the RSC adoption.
PROGRAM FOR THE DELIVERY OF BASIC NECESSITIES OF A WAREHOUSE DURING THE COVID-19 PANDEMIC
Authors: Barojas-Payán Erika , de la Cruz-Zopiyactle Elsa-Nereyda , Sánchez-Partida Diana , Sánchez-Bazán Ignacio , Juárez-Rivera Victorino
Published: March 2022

The purpose of the research is to reduce the logistics costs of a warehouse supplier of products belonging to the primary consumer located in the central area of the State of Veracruz, Mexico. There is an increase in the number of stores to supply due to the quarantine. As a result, its high costs have been negatively affected. Therefore, the project focuses on minimizing the distances travelled in delivering its products, which will reduce costs. From applying vehicle routing with capacity (CVRP), a redesign of delivery routes is carried out weekly, proposing a new weekly delivery schedule of 22 routes and 162 destinations. Whit the CVRP application decreased 23.61% in the distance travelled even with an 8% increase in recipients. Thus, it reflects the fulfilment of the delivery objective to the current stores and those added by the warehouse. The research addresses two problems, first the costs incurred by the warehouse for the delivery of its products. The second is the increase in supply due to the initiative to prevent the spread of the COVID-19 virus, avoid the displacement of long distances to purchase products by the inhabitants and reduce those who attend the stores' Warehouse supplies.
IMPROVING COMPETITIVENESS OF SMALL AND MEDIUM ENTERPRISES BASED ON LOCAL LEADING PRODUCTS IN TARAKAN CITY, INDONESIA
Authors: Nur Utomo Mohamad , Kaujan Kaujan , Cahyaningrum Widyastuti
Published: March 2022

The competitiveness of SMEs is enhanced by compiling a map consisting of local superior employment sectors and local superior products. This study aims to identify and map the work sector and products of Small and Medium Enterprises that need to be developed to become the local carrying capacity of Tarakan City. Sources of data include primary data (questionnaires from respondents) and secondary data (GRDP data for the city of Tarakan). Data analysis methods include Location Quotient (LQ), Klassen Typology, and Analytical Hierarchy Process (AHP). The results showed that the fishery-based processing industry is an employment sector that has great potential to become a local leading sector in Tarakan City. The results also reveal that the competitiveness of SMEs can be increased by developing local superior products. This development must meet three criteria, respectively: development must be oriented towards the conservation of resources and the environment; its development must only involve products with local raw materials and local uniqueness, and its development is supported by local communities. Another finding is about three priority local superior products, namely Dried Fish/Peyek Pepija, Shredded Milkfish, and Amplang Milkfish Crackers. These results can be used as a basis for making policies regarding the development of a country's local superior products.
VEHICLE ASSIGNMENT WITH PENALTY COSTS: A CASE OF MEXICAN FREIGHT TRANSPORT
Authors: Bueno-Pascual Felix Eduardo , Martinez-Flores Jose Luis , Sanchez-Partida Diana , Cano-Olivos Patricia
Published: March 2022

The reduction of logistics costs is very important for Mexican companies, especially for those from freight transport industry. They must manage their operations efficiently and effectively to increase the revenue, which is reduced if trucks are not being productive. The objective of this research is to provide a model for a Mexican freight transport company, which lets the company reduce transportation costs, based on assignment models to make daily assignment programme of trucks. One particularity of the model being built is the fact that it will not only include general costs as in a Generalised Assignment Procedure (GAP), but also penalty costs caused by truck drivers. The main problem consisted in minimize the total cost of assigning 100 vehicles owned by the company to 10 routes (in which it was required to be transported molasse, and sand), considering that trucks cannot be assigned to some routes due to their characteristics, as well as they must assign different operators to the routes (which are classified as A, B, and C, depending on the characteristics like license type, performance, among others); thus, it was able to assign 100 operators with different characteristics to 100 different units required in 10 routes to satisfy market demands, achieving a reduction about 44.11% of current costs related to assignment, maintenance, idle time, penalty, and logistics costs.
EXPLORING METABOLIC AND STOICHIOMETRIC CONTROLS FOR NUTRIENT EXCRETION: BODY SIZE HAS PRIMACY IN A TROPICAL STREAM FISH COMMUNITY
Authors: Oliveira-Cunha Priscila , McIntyre Peter B. , Neres-Lima Vinicius , Caliman Adriano , Moreira-Ferreira Beatriz , Zandona Eugenia
Published: March 2022

Discussions of the factors regulating nutrient recycling by consumers
have focused on predictions from Ecological Stoichiometry (ES) and the
Metabolic Theory of Ecology (MTE). ES posits that imbalances between the
composition of an animal’s body tissues and its diet should determine
its nutrient excretion rates, whereas the MTE predicts that excretion
should directly reflect metabolic activity arising from body size and
temperature. Each framework has been supported by data, but they are
rarely tested together. In this study, we measured excretion rates of
nitrogen (NH4), phosphorus (SRP) and N:P excretion ratio, body N:P
stoichiometry, body size, and temperature for 12 species of fish from an
Atlantic rainforest stream in Brazil. We fitted 8 competing models
reflecting different combinations of ES (body N:P, armor classification,
diet group) and MTE (body size, temperature) variables. For both N and P
excretion, as well as excreted N:P ratio, only body size was included in
the best model, and interspecific differences in size-scaling were
greater for N than for P. Fitted size scaling coefficients were lower
than the MTE prediction of 0.75 for both N (0.59, 95% CI = 0.45, 0.73)
and P (0.56, 95% CI = 0.40, 0.77). There was only weak evidence that
body armor in 3 of 12 species led to more retention of P, and there was
no discernable effect of diet group, body N:P, or water temperature. We
conclude that differences in nutrient excretion among species within a
shared environment primarily reflect contrasts in metabolic rates
arising from body size, rather than disparities between consumer and
resource stoichiometry. Our findings align with those from other
ecosystems and synthesis across aquatic taxa, expanding support for the
MTE as the primary framework for predicting nutrient excretion rates.
Key words: ecological stoichiometry, metabolic ecology, animals,
nitrogen, phosphorus, freshwater.
Anticoagulation for Left Ventricular Thrombi Secondary to COVID -- Is Three Months Too Long?
Authors: Garg Rimmy , Sachdeva Amitoj , Fratti Juan Del Cid , Mortoti Samuel
Published: March 2022

Length of anticoagulation for thrombotic events related to COVID-19 is
unknown. We present a patient with COVID-19 complicated by a thrombotic
anterior STEMI and multiple left ventricular (LV) thrombi that resolved
after 8 weeks of anticoagulation. We suggest a shorter length of
anticoagulation with COVID-19 related LV thrombus.
Collective and harmonised high throughput barcoding of insular arthropod biodiversity: toward a Genomic Observatories Network for islands
Authors: Emerson Brent , Borges Paulo , Cardoso Pedro , Convey Peter , deWaard Jeremy , Economo Evan , Gillespie Rosemary , Kennedy Susan , Krehenwinkel Henrik , Meier Rudolf , Roderick George , Strasberg Dominique , Thébaud Christophe , Traveset Anna , Creedy Thomas , Meramveliotakis Emmanouil , Noguerales Victor , Overcast Isaac , Morlon Hélène , Papadopoulou​ Anna , Vogler Alfried , Arribas Paula , Andujar Carmelo
Published: March 2022

Our current understanding of ecological and evolutionary processes
underlying island biodiversity is heavily shaped by empirical data from
plants and birds, although arthropods comprise the overwhelming majority
of known animal species. This is due to inherent problems with obtaining
high-quality arthropod data. Novel high throughput sequencing approaches
are now emerging as powerful tools to overcome such limitations, and
thus comprehensively address existing shortfalls in arthropod
biodiversity data. Here we explore how, as a community, we might most
effectively exploit these tools for comprehensive and comparable
inventory and monitoring of insular arthropod biodiversity. We first
review the strengths, limitations and potential synergies among existing
approaches of high throughput barcode sequencing. We consider how this
can be complemented with deep learning approaches applied to image
analysis to study arthropod biodiversity. We then explore how these
approaches can be implemented within the framework of an island Genomic
Observatories Network (iGON) for the advancement of fundamental and
applied understanding of island biodiversity. To this end, we identify
seven island biology themes at the interface of ecology, evolution and
conservation biology, within which collective and harmonised efforts in
HTS arthropod inventory could yield significant advances in island
biodiversity research.
LEVEL OF MATERNAL ANTIBODIES AGAINST RESPIRATORY SYNCYTIAL VIRUS (RSV) NUCLEOPROTEIN AT BIRTH AND RISK OF RSV VERY-SEVERE LOWER RESPIRATORY TRACT INFECTION
Authors: RECEVEUR Matthieu , Ottmann Michele , Reynes Jean-Marc , Eleouet Jean-François , Galloux Marie , Receveur Aurore , Ploin Dominique , Fiorini Sylvie , Rivat Nathalie , Valette Martine , Lina Bruno , casalegno jean-sebastien
Published: March 2022

Background: The nucleoprotein (N protein) of respiratory syncytial virus
(RSV) is a candidate antigen for new RSV vaccine development. The aim of
the present study was to investigate the association between maternal
antibody titers against the RSV N protein at birth and the newborns’
risk of developing very-severe lower respiratory tract infection
(VS-LRTI). Methods: In this single-center prospective cohort study, 578
infants born during the RSV epidemic season in France were included.
Among these, 36 were hospitalized for RSV VS-LRTI. A generalized linear
model was used to test the occurrence of a VS-LRTI in function of sex,
mode of delivery, parity of the mother, type of pregnancy, date of birth
in relation to the peak of the epidemic, and antibody titer against N
protein. Results: All cord blood samples had detectable antibodies
against N protein. The mean titers were significantly lower in newborns
with risk factors for RSV severe LRTI (preterm infants, birth before the
peak epidemic, multiparous mother). There was no association between
antibody titer against the N protein and a protection against VS-LRTI.
Conclusions The present study found that transfer of maternal antibodies
against the RSV N protein may not provide a significant immune
protection early in infancy. Clinical Trials Registration. NCT04144816.
Sensor Location Selection for Continuous Pulp Digesters with Delayed Measurements
Authors: Zhang Lu , Xie Junyao , Dubljevic Stevan
Published: March 2022

The state estimation and sensor placement for a continuous pulp digester
with delayed measurements are investigated. The underlying model of
interest is heat transfer in a pulp digester modeled by two coupled
hyperbolic partial differential equations and an ordinary differential
equation. Output measurements are considered with delay due to the
possible low sampling rate. The Cayley-Tustin transformation is utilized
to realize model time discretization in a late lumping manner which does
not account for any type of spatial approximation or model reduction.
The discrete Kalman filter is applied to estimate the system states
using the delayed measurements. The selection of sensor location is
addressed along with estimator design accounting for the delayed
measurements and investigated by minimizing the variance of estimation
error. The performance of the state estimator is evaluated, and the
sensor placement is analyzed through simulation studies, which provide
guidance for sensor location selection in industrial applications.
KERAJINAN KAPUK DI DESA TEGALLINGGAH, SUKASADA, BULELENG, BALI (Sejarah Kemunduran, Adaptasi dan Nilai-nilai Pendidikan Karakter Sebagai Sumber Bagi Pembelajaran Sejarah Di SMA/MA)
Authors: Yasa I gede beni aprisma , Atmadja Nengah bawa , Maryati Tuty
Published: March 2022

Penelitian ini bertujuan untuk (1) Mengetahui mengapa kerajinan kapuk di Desa Tegallinggah mengalami kemunduran (2) Bagaimana pola adaptasi yang dilakukan oleh penggerajin kapuk (3) Nilai-nilai pendidikan karakter apa yang ada dibalik dinamika kerajinan kapuk di Desa Tegallinggah yang dapat digunakan sebagai sumber belajar sejarah. Penelitian ini menggunakan pendekatan kualitatif,  dengan lokasi penelitian di desa Tegallinggah. Penentuan informan menggunakan purposive sampling dan snowball sampling, prosedur pengumpulan data dengan cara observasi, wawancara, dan studi dokumen. Hasil penelitian menunjukkan bahwa (1) Kemunduran usaha kerajinan kasur dan bantal kapuk di desa Tegallinggah disebabkan oleh a) Tidak kompeten dalam manajerial, b) Kurang berpengalaman, c) Kurang dapat mengendalikan keuangan, d) Gagal dalam perencanaan, e) Lokasi yang kurang memadai, f) Kurangnya pengawasan peralatan, g) Sikap kurang sungguh-sungguh dalam berusaha, h) Ketidakmampuan dalam melakukan peralihan kewirausahaan. (2) Pola adaptasi yang dilakukan oleh para pengerajin kapuk yaitu: (a) Adaptasi kultural (b) Adaptasi srtuktural (c) Adaptasi proses produksi (d) Adaptasi sistem pemasaran. (3) Nilai nilai yang dipegang teguh oleh para pengerajin kapuk di desa Tegallinggah, dari 18 nilai pendidikan karakter menurut Kementerian Pendidikan Nasional (Kemendiknas) yang dimiliki oleh para pengerajin kapuk diantaranya religious, jujur, toleransi,disiplin, kerja keras, kreatif, rasa ingin tahu dan tanggung jawab.
HUBUNGAN SOSIOKULTURAL NYEGARA GUNUNG ANTARA PURA PEGONJONGAN DENGAN PURA DALEM BALINGKANG SERTA POTENSINYA SEBAGAI SUMBER BELAJAR SEJARAH
Authors: Sinta Devi Kadek Mega Arista , Maryati Tuty , Arta Ketut Sedana
Published: March 2022

Penelitian ini bertujuan untuk: (1) untuk mengetahui kondisi sosial-budaya di sekitar Pegonjongan dan Dalem Balingkang. (2) untuk mengetahui pola hubungan nyegara gunung antara Pegonjongan dan Dalem Balingkang. (3) untuk mengetahui aspek-aspek dari hubungan sosiokultural nyegara gunung antara Pegonjongan dan Dalem Balingkang sebagai sumber belajar sejarah. Metode yang digunakan adalah deskriptif-kualitatif meliputi: (1) lokasi penelitian terletak di Pura Pegonjongan, Desa Sambirenteng, Buleleng, Bali dan Pura Dalem Balingkang, Desa Pinggan, Bangli, Bali. (2) teknik penentuan informan dilakukan dengan teknik purposive sampling dan snow ball. (3) teknik pengumpulan data menggunakan teknik observasi, wawancara, studi dokumen. (4) teknik validasi data menggunakan triangulasi metode dan triangulasi sumber. (5) teknis analisis data terdiri dari: pengumpulan data, pengolahan data, dan analisis data. Hasil penelitian menunjukkan bahwa: Pola hubungan nyegara gunung berkaitan dengan kedatangan pedagang Cina yang mendarat di Pantai Timur Bali Utara, kemudian terjadi akulturasi antara kebudayaan Bali Kuno dengan Cina serta amalgamasi antara Raja Bali Kuno dengan Putri Cina yang mempengaruhi dinamika masyarakat Bali. Sehingga adanya beberapa kesamaan budaya antara Pegonjongan dan Dalem Balingkang. hubungan sosiokultural nyegara gunung antara Pegonjongan dan Dalem Balingkang yang dapat digunakan sebagai sumber belajar sejarah: aspek spiritual, aspek sosial, aspek pengetahuan, aspek historis, dan aspek peninggalan.
PELABUHAN PENYEBRANGAN GILIMANUK DI DESA GILIMANUK KECAMATAN MELAYA KABUPATEN JEMBRANA (LINTASAN SEJARAH, DAMPAK SOSIAL EKONOMI DAN EKOLOGI, SERTA POTENSINYA SEBAGAI SUMBER PEMBELAJARAN SEJARAH LOKAL DI SMA)
Authors: Agistin Duwi Maulida , Atmadja Nengah Bawa , Maryati Tuty
Published: March 2022

Penelitian ini bertujuan untuk mengetahui (1) Lintasan sejarah berdirinya pelabuhan penyebrangan Gilimanuk di Desa Gilimanuk, Jembrana, Bali (2) Dampak sosial, ekonomi, dan ekologi bagi masyarakat (3) Aspek-aspek dari keberadaan pelabuhan Gilimanuk yang memiliki potensi sebagai sumber belajar sejarah lokal di SMA. Metode penelitian yang digunakan yaitu metode  penelitian sejarah dengan pendekatan deskriptif kualitatif meliputi: (1) Lokasi penelitian terletak di pelabuhan penyebrangan Gilimanuk, Desa Gilimanuk, Jembrana, Bali. (2) Teknik penentuan informan menggunakan informan kunci, dikembangkan lagi mencari informan bantuan. (3) Teknik pengumpulan data menggunakan tiga teknik yaitu: observasi, wawancara,studi dokumen (4) Teknik penjaminan keaslian data dengan menggunakan dua teknik yaitu: triangulasi sumber dan triangulasi metode. (5) Teknik analisis data yang terdiri dari pengumpulan data, reduksi data, penyajian data, verifikasi. Hasil penelitian ini lintasan sejarah pelabuhan penyebrangan Gilimanuk serta dampak sosial, ekonomi dan ekologi bagi masyarakat serta aspek-aspek dari keberadaan pelabuhan Gilimanuk yang memiliki potensi sebagai sumber belajar sejarah lokal di SMA.