bluuebunny/crossref_metadata_2025 huggingface dataset:
Nurse and Physician Involvement in Health Risk Appraisals: An Integrative Review
Authors: Simpson Vicki , Pedigo Lindsey
Published: July 2016

Unhealthy lifestyle behaviors continue to be a strong contributor to chronic illness and death in the United States. Despite the health care system’s efforts to refocus on prevention, primary care visits remain acute care focused. Health risk appraisals are tools that can be used by primary care providers to enhance lifestyle behavior change and prevention efforts. The purpose of this integrative review is to examine nurse and physician use of health risk appraisals in primary care. A total of 26 national and international papers, selected through an electronic database and ancestry search, were reviewed. Identified nurse and physician interventions in addition to other programming included helping participants understand and interpret feedback, behavioral counseling, and development of plans to address unhealthy lifestyle behaviors. The most common intervention was provision of telephonic nurse advice lines. Overall outcomes were positive. The use of these tools could be key to enhancing primary care prevention.
Is Active Representation an Organizational-Level Process? The Indirect Effect of Bureaucrats on Clients They Don’t Directly Serve
Authors: Favero Nathan , Molina Angel Luis
Published: July 2016

A now well-established link exists between passive representation of racial and gender minorities in certain bureaucracies and substantive benefits for the represented groups. However, few quantitative studies have distinguished between the multiple possible mechanisms by which passive representation might produce such effects. We conduct a novel set of empirical analyses aimed at determining whether or not passive representation produces effects only for those clients who directly interact with bureaucrats who share their demographic characteristics or if passive representation produces broader organizational-level effects. We find strong evidence that minority clients’ outcomes are positively associated with representation in portions of the bureaucracy with which they do not directly interact. This suggests that either passive representation produces substantial bottom-up, organizational-level effects or that managers who recruit minority personnel also adopt policies that are favorable toward minority clients.
Innovation by coercion: Emerging institutionalization of university–industry collaborations in Russia
Authors: Bychkova Olga
Published: July 2016

This article explores the emerging institutionalization of collaborative university–industry networks in Russia. The Russian government has attempted to use a top-down public policy scheme to stimulate and promote network-building in the R&D sector. In order to understand the initial organizational responses that universities and companies select while structuring collaborations, the article utilizes conceptual perspectives from institutional theory, especially drawing on arguments from strategic choice, network-building, and network failure studies.
Spatial heterogeneity as a component of river geomorphic complexity
Authors: Wohl Ellen
Published: July 2016

One component of geomorphic complexity results from spatial heterogeneity in river corridors. The characteristics of this form of complexity have important implications for habitat and biodiversity, attenuation of downstream fluxes, resistance and resilience of river ecosystems, river processes, ability to characterize patterns and changes through time, and river management and restoration. Numerous measures of complexity have been applied to heterogeneity from spatial scales of bed grain size distribution to entire river networks. Studies explicitly incorporating geomorphic complexity have increased substantially since 2000, but there is no single, widely used metric of complexity. Despite increasingly explicit scientific appreciation of the importance of complexity in river corridors, public attitudes toward rivers continue to emphasize an attractive appearance, which commonly equates to a physically simple and homogeneous river corridor.
The assessment of air emissions increase due to the collection of municipal solid waste with old collection vehicles: A case study of Ludbreg (Croatia)
Authors: Radetić Luka , Vujević Dinko , Premur Vitomir , Melnjak Ivana , Anić Vučinić Aleksandra
Published: July 2016

The usage of old equipment (over 10-year-old diesel-fuelled waste collection vehicles, WCVs) for municipal solid waste (MSW) collection in Ludbreg for longer than a decade has had a negative environmental impact, which has been reduced by replacing an old diesel WCV with a new diesel WCV. This study aims to assess the share of air emissions of two old WCVs (FAP 1990 and MAN 2003) and one new (MAN 2015), expressed in CO2 emissions. In addition, these vehicles have been found easily to reach the limit of 100 dB, which can cause hearing damage in their surroundings. Furthermore, their average fuel consumption is more than 80 l per 100 km, which makes them ineffective in terms of fuel consumption. Generally, higher fuel consumption results in more emissions and for a more eco-friendly operation, the MAN 2003 from Ludbreg WCV fleet should be technically amended and adjusted, and the FAP 1990 should be retired. Although the MAN 2015 is diesel fuelled, the best solution for replacement, according to Maimoun et al. ( Waste Management 33: 1079–1089, 2016), would be the use of hydraulic-hybrid vehicles, which provide the best environmental benefits over other alternatives. According to Maimoun et al., hybrid is better environmentally, diesel is the best environmental–economical option and landfill gas-sourced natural gas is the best alternative when accessible because it significantly (up to 80%) reduces emissions of hazardous gases as well as noise levels (50–98%).
A multi-additive suppressant agent–based low-flow and long-distance firefighting approach for suppressing wildfires near electrical transmission lines
Authors: Lu JiaZheng , Chen Bao-Hui , Wu ChuanPing , Liu Xing , Zhou TeJun , Tan YanJun
Published: July 2016

The key challenges of the wildfire firefighting were long-distanced and high-lifted fire events and limited water access in wildlands. This article proposed a new low-flow and high-lift firefighting approach for the application of wildfire near transmission lines. To solve the challenges, we developed a comprehensive firefighting equipment set which consisted of a high-effective suppressant agent with properties to prevent reignition and a mobile firefighting platform with long-distance and high-lift features. The liquid suppression agent improved the effectiveness of fire suppression while reducing the consumption of water significantly. As the hydraulic flow was decreased for a given volume of water, the hydraulic pressure was increased. In this way, the platform can produce a hydraulic pressure over 120 bar for an effective lift of 500 m. The results of field experiments demonstrated that the proposed approach is able to control wildfires over a long distance and high lift, which proved the effectiveness of the approach.
Incorporating Vocabulary Instruction in Individual Reading Fluency Interventions With English Language Learners
Authors: Johnston Lauren E. , Mercer Sterett H. , Geres-Smith Rhonda
Published: July 2016

The purpose of this preliminary study was to determine whether incorporating vocabulary instruction in individual reading fluency interventions for English Language Learners (ELLs) would improve reading comprehension. Two vocabulary instructional procedures were contrasted with a fluency-building only condition in an alternating-treatments design with four ELL students in Grades 3 and 5. Results indicated that the two vocabulary instructional procedures, on average, did not affect reading comprehension. Despite no consistent overall effects, one student had better comprehension of passages used in fluency-building activities when definitions of key target words were taught, and two students demonstrated better comprehension of untaught passages following vocabulary instruction that included processing questions; however, all effects were of small magnitude. Reducing instructional time spent on fluency-building activities to incorporate the vocabulary activities did not attenuate intervention effects on reading fluency. Practical recommendations and future directions for incorporating vocabulary instruction in individual reading interventions are discussed.
Deconstructing the Myths About Intimate Partner Violence: A Critical Discourse Analysis of News Reporting in Hong Kong
Authors: Leung Lai-Ching
Published: July 2016

This article depicts the dominant discourses on intimate partner violence (IPV) in newspaper reports and discusses how the myths about IPV are perpetuated in news reporting in Hong Kong. The myths about IPV consist of a set of prevalent assumptions in society that adversely affect the help-seeking behavior of survivors and impede social change. It is sometimes assumed that the victims cause the abuse and are personally responsible for solving the problem. This study reveals how news reporting in Hong Kong perpetuates the myths about IPV by engendering unequal power relations through the language and text used in newspapers. A critical discourse analysis is performed to depict the language used in the text and the embedded meanings in discourses on IPV in two popular local newspapers, Apple Daily and Ming Pao. The findings indicate that the two newspapers tend to use five major discursive frameworks in their reporting on IPV, namely, (a) gender symmetry, (b) stereotyping the abuser, (c) labeling the abused, (d) blaming the victim, and (e) ignoring women’s rights. The study reveals evidence of the systematic stereotyping of IPV abusers and blaming of survivors in newspaper reporting. These powerful discourses may perpetuate the myths about IPV and marginalize IPV survivors in society.
Negotiating Personal Needs and Authenticity
Authors: Smith Dina C. , Stannard Casey R.
Published: July 2016

Regency dress is worn today by members of historic groups such as the Jane Austen Society. The historic style of dress plays a major role in the activities of Regency groups. Therefore, the purpose of this research was to examine the design decisions related to the personal needs and the desire for authenticity of reenactors creating Regency gowns as a historic style of dress. Data were collected using a netnographic approach. Blogs discussing the creation of 19 Regency gowns made by reenactors were analyzed to determine how the designers balanced their personal needs with their desire for authenticity. The gowns discussed in these blogs were made to be both wearable and authentic; thus, three major categories emerged from the data: personal needs, authenticity, and limitations encountered when creating Regency gowns. Finally a model, Historic Styles of Dress Design Considerations Model, was developed.
Mechanical, thermal, and morphological properties of nanoporous reinforced polysulfone membranes
Authors: Pouresmaeel-Selkjani Peyman , Jahanshahi Mohsen , Peyravi Majid
Published: July 2016

The effect of three different diphenols including 1,1′-thiobis(2-naphthol) (TBN), 2,2′-thiobis(4-methyl phenol) (TBMP) and curcumin (CUR) used in the preparation of sulfonated poly(ether sulfide sulfone) (SPESS) on the mechanical, thermal, and morphological properties of polysulfone (PSf) membranes was studied. In this regard, the morphological characteristics of the nanoporous membranes were explored by developed image analyzer program. Based on the obtained results, PSf membrane modified by SPESS-TBN copolymer showed the best nominal tensile strength in comparison to the other samples with the value of 206 MPa. The optimum real tensile strength with the value of 322 MPa was observed for SPESS-TBMP membrane. It was found that the addition of SPESS, improved the mechanical and thermal properties as well as the performance of membranes. Inspections of scanning electron microscopic images for evaluation of the void properties of membranes revealed that there were 42.3, 8.76, 41.45 and 15.92% of void contents within the structures of neat PSf membrane, SPESS-CUR, SPESS-TBMP and SPESS-TBN, respectively. Moreover, some conceptual relations between morphological and mechanical properties were presented. Finally, the effect of the membrane chemical structure on the mechanical, thermal, and morphological properties was discussed in this study.
Correlation between climate and grain harvest fluctuations and the dynastic transitions and prosperity in China over the past two millennia
Authors: Yin Jun , Fang Xiuqi , Su Yun
Published: July 2016

The social impacts of climate change constitute an important field within the study of global change. The impacts of historical climate change on dynastic transitions and prosperity in China from a food safety perspective is a helpful research topic that contributes to a better understanding of the impacts, process, and mechanism of climate change, as well as a reference for projecting the impacts of climate change in the future. This study defined the periods of dynastic transitions and prosperity in China from 210 BC to AD 1910 and analyzed the relationships among dynastic transition or dynastic prosperity, climate change, and grain harvests. From 210 BC to AD 1910, dynastic transitions mostly coincided with cold ages or the periods that changed from warm to cold and dry or wet-to-dry periods when there was relatively poor harvest. In contrast, dynastic prosperity mostly coincided with warm ages or the periods that changed from cold to warm and wet or dry-to-wet periods when there was relatively bumper harvest. Meanwhile, the dynastic transitions from a divisive dynasty to a unified dynasty often came with a progressively warm phase on the century scale when grain harvests increased. Interestingly, the division of a unified dynasty often came with a progressively cold phase and poor harvests. Furthermore, changes in temperature and agricultural production may be one of the most important factors leading to the collapse of Tang Dynasty. In conclusion, the fluctuation of grain harvests and climate change correspond with the transitions between a tumultuous society and an ordered one, which reveals that the social sensitivity periods were often a result of a change to a colder climate on the century scale.
Holocene history of a raised bog, northern New Zealand, based on plant cuticles
Authors: Haenfling Carolin , Newnham Rewi , Rees Andrew , Jara Ignacio , Homes Aline , Clarkson Beverley
Published: July 2016

We present a method for analysing subfossil plant cuticles preserved in peat and apply the method to provide a preliminary, coarse resolution reconstruction of Holocene vegetation history at Moanatuatua Bog, northern North Island, New Zealand. The plant cuticle record reveals the early-Holocene development of a swamp and its transition to a raised bog, which is not apparent from other proxies. Comparison with a pollen record from the same sequence highlights the advantages of plant cuticle analysis in cases where pollen is hard to identify or poorly preserved. In particular, distinguishing between the pollen grains of the two main bog species, the restiads Empodisma robustum and Sporadanthus ferrugineus, relies on subtle gradational characteristics, whereas their cuticular patterns are very distinct. Furthermore, Cyperaceae pollen is poorly preserved at Moanatuatua Bog, being almost completely absent, whereas the Cyperaceae cuticles are present throughout the sequence. Therefore, we suggest that Cyperaceae pollen at this site is a less reliable indicator of local sedge communities than the cuticle record. The wide dispersal capabilities of these wind-dispersed pollen types also make them less suitable for determining local site vegetation and environmental change in comparison with cuticle remains. These results suggest that plant cuticle analysis may be a useful tool for the reconstruction of long-term vegetation changes from peat sequences, especially when used in concert with palynology. Sample preparation also proved to be fast with little equipment or chemicals needed.
Stalagmite multi-proxy evidence of wet and dry intervals in northeastern Namibia: Linkage to latitudinal shifts of the Inter-Tropical Convergence Zone and changing solar activity from AD 1400 to 1950
Authors: Voarintsoa Ny Riavo G , Brook George A , Liang Fuyuan , Marais Eugene , Hardt Ben , Cheng Hai , Edwards R Lawrence , Railsback L Bruce
Published: July 2016

Multiple proxies using variation in δ18O, δ13C, mineralogy, and petrography in a newly generated high-resolution record of Stalagmite DP1 from Dante Cave indicate a linkage between changes in hydroclimate in northeastern Namibia and changes in solar activity and changes in global temperatures. The record suggests that during solar minima and globally cooler conditions (ca. 1660–1710 and ca. 1790–1830), wetter periods (reflecting longer summer seasons) in northeastern Namibia were linked to advances of the Inter-Tropical Convergence Zone (ITCZ) and the Inter-Ocean Convergence Zone (IOCZ) southwestward. A slight southward push of the Angola–Benguela Front (ABF) during such intervals could also be expected, bringing more rainfall inland. On the other hand, drier and warmer periods in northeastern Namibia, inferred from the increasing δ18O trend in Stalagmite DP1 after AD 1715, coincide with globally warmer conditions, and thus a northeastward migration of the ITCZ, specifically with more warming of the Northern Hemisphere (NH). This finding agrees with reducing precipitation observed in the summer rainfall zone of southern Africa since ca. 1900. Therefore, predictions of warming in high-latitude regions of the NH in the next century should suggest that the presently semi-arid climate of northern Namibia may become even drier.
Validation of an Argentine version of Lupus Quality of Life questionnaire
Authors: Machado Escobar M A , Yacuzzi M S , Martinez R N , González Lucero L , Bellomio V I , Santana M , Galindo L , Mayer M M , Barreira J C , Sarano J , Gomez G , Collado M V , Martinez A , Orozco M C , Betancur G , Dal Pra F , Sanchez A , Juarez V , Lucero E V
Published: July 2016

Objective

To determine reproducibility and validity of an Argentine version of the Lupus Quality of Life questionnaire (LupusQoL) and to determine cut-off values in the questionnaire.

Materials and methods

One hundred and forty-seven systemic lupus erythematosus patients (American College of Rheumatology 1982/1997) were assessed from April 2014 to July 2014. Demographic and socioeconomic variables were collected, as well as SELENA/SLEDAI, Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index Score, comorbidities and treatment data. Patients completed LupusQoL-Argentine version and European Quality of Life Questionnaire (EuroQoL-5D). Internal consistency and reliability were examined. Convergent validity with EuroQoL-5D was assessed through analysis of latent classes, which established homogeneous categories from the responses of each domain of LupusQoL and for the total.

Results

Out of 147 patients, 93.2% were female, mean age 36.4 ± 11.1 years, mean disease duration 2.7 ± 9 years, mean SELENA/SLEDAI 2.7 ± 3 points. The cut-off point that defined good or bad quality of life was 0.739 for EuroQoL 5D and 63 for LupusQoL. Cut-off values for each LupusQoL domain were also defined, creating two classes in each of them. There was moderate to high concordance to classify quality of life (Kappa = 0.74, 95% confidence interval = 0.54, 0.95).

Conclusion

The Argentine version of LupusQoL is a valid, reliable and reproducible instrument to assess quality of life. In this study, cut-off points that allow the classification of patients regarding whether they have good or bad quality of life are established for the first time.
The part-time wage penalty: Does bargaining coverage outweigh regional differences in Spain?
Authors: Ramos Raul , Sanromá Esteban , Simón Hipólito
Published: July 2016

The use of part-time jobs is steadily increasing in most advanced economies. Previous literature has concluded that part-time workers suffer a wage penalty, but its magnitude varies across studies and countries. The part-time penalty is the otherwise unexplained element of the gap between full-time and part-time hourly earnings. One potential factor accounting for international differences in this penalty is the coverage of collective bargaining. This article outlines research examining wage differences between part-time and full-time male and female workers in Spain, a country with a very high level of coverage of collective agreements but very heterogeneous regional labour markets. Results are obtained using an econometric decomposition specifically adapted to matched employer–employee data. They show that intra-firm wage differentials for part- and full-time workers with the same characteristics are negligible. But results that are perhaps less expected are those based on the regional analysis – an unprecedented perspective compared with the previous literature. These results show that despite very significant differences in economies and labour markets, observed wage gaps between part-time and full-time workers in each Spanish region are also mainly explained by different endowments of individual, job and firm characteristics. Overall, our evidence highlights the over-riding role of wage setting mechanisms, specifically collective bargaining coverage, in minimising inter-regional differences in the wage penalty of part-time workers.
Theoretical Perspectives on Issues and Interventions Related to Migrant Resettlement in Canada
Authors: Toosi Amy , Richter Solina , Woytowich Boris
Published: July 2016

International migration has increased at a significant rate over the past several decades as many migrants relocate in the hope of finding better living conditions. Unfortunately, not all migrants realize their dreams but instead find themselves in poor living conditions and are less satisfied with their health and well-being. The purpose of this article is to explore the factors that influence the integration of migrants into a new culture through two theoretical lenses: transitions theory and acculturation theory. The authors propose that acculturation and transition are influenced by factors at both the societal and individual level and therefore interventions aimed at promoting successful integration should be focused at both those levels. This article adds a new perspective to the migrant health framework and offers a new approach for researchers, clinicians, and program developers. The overall health and well-being of migrants may improve by focusing on individual factors that contribute to successful settlement through predeparture or early arrival preparation programs.
Hospice Palliative Care Volunteers as Program and Patient/Family Advocates
Authors: Claxton-Oldfield Stephen , Blacklock Krystal
Published: July 2016

The objectives of this study were to examine (1) the extent to which hospice palliative care volunteers are involved in program and patient/family advocacy, (2) volunteers’ willingness to engage in program and patient/family advocacy, and (3) volunteers’ perceived needs for training on how to be an effective advocate. Thirty-four hospice palliative care volunteers responded to the survey developed for this study. The majority of the volunteers surveyed consider themselves advocates for their programs and many of those, who have not already done so, would be willing to promote their program (eg, give a community presentation, talk to local media) if asked. Half of the volunteers were aware of unmet needs of the patients/families they supported, and just over one-third wanted to advocate on behalf of their patients/families but did not know what to do or where to go. Recommendations for volunteer training are made.
Diagnostic Differentiation of von Willebrand Disease Types 1 and 2 by von Willebrand Factor Multimer Analysis and DDAVP Challenge Test
Authors: Michiels Jan Jacques , Smejkal Petr , Penka Miroslav , Batorova Angelika , Pricangova Tatiana , Budde Ulrich , Vangenechten Inge , Gadisseur Alain
Published: July 2016

The European Clinical Laboratory and Molecular (ECLM) classification of von Willebrand disease (vWD) is based on the splitting approach which uses sensitive and specific von Willebrand factor (vWF) assays with regard to the updated molecular data on structure and function of vWF gene and protein defects. A complete set of FVIII:C and vWF ristocetine cofactor, collagen binding, and antigen, vWF multimeric analysis in low- and medium-resolution gels, and responses to desmopressin (DDAVP) of FVIII:C and vWF parameters are mandatory. The ECLM classification distinguishes recessive types 1 and 3 vWD from recessive vWD 2C due to mutations in the D1 and D2 domains and vWD 2N due to mutations in the D′-FVIII-binding domain of vWF. The ECLM classification differentiates between mild vWD type 1 with variable penetrance of bleedings from symptomatic dominant type 1 vWD secretion defect and/or clearance defect with normal vWF multimers versus vWD 1M and 2M with normal or smeary vWF multimers in low- and medium-resolution gels. High-quality multimeric analysis of vWF in medium-resolution gels based on a DDAVP challenge test clearly delineates and distinguishes each of the dominant type 2 vWDs 1/2E, 2M, 2B, 2A, and 2D caused by vWF gene mutations in the D3 multimerization domain, loss or gain-of-function mutations in the glycoprotein Ib receptor A1 domain, gene mutations in the A2 proteolytic domain, and the C-terminal dimerization domain, respectively.
Timing of Symptomatic Infarct Swelling Following Intravenous Thrombolysis in Acute Middle Cerebral Artery Infarction: A Case–Control Study
Authors: Lin Ting-Chun , Lee Jiann-Der , Lin Ya-Hui , Yuan Rey-Yue , Weng Hsu-Huei , Huang Ying-Chih , Lee Meng , Wu Chih-Ying , Hsu Huan-Lin , Hsu Chia-Yu , Lee Tsong-Hai , Liu Shan-Jin , Chang Yeu-Jhy , Chang Chien-Hung , Peng Tsung-I , Liou Chia-Wei , Chang Ku-Chou , Pan Yi-Ting , Huang Yen-Chu
Published: July 2016

Background:

The risk of symptomatic infarct swelling has been reported to be higher in patients treated with recombinant tissue plasminogen activator (rt-PA). The aim of this study was to evaluate the timing of symptomatic infarct swelling after rt-PA treatment.

Methods:

We retrospectively analyzed 14 868 patients with acute ischemic stroke from a stroke registry databank. We recruited patients with massive middle cerebral artery (MCA) infarction and symptomatic infarct swelling and excluded those with parenchymal or symptomatic hemorrhage. Multiple linear regression and multivariate logistic regression analyses were used to estimate the impact of rt-PA on the timing of symptomatic infarct swelling.

Results:

A total of 23 patients with rt-PA treatment and 117 patients without rt-PA treatment were included. The rt-PA treatment group had a lower rate of coronary artery disease (8.7% vs 32.5%; P = .023), lower severity of baseline National Institutes of Health Stroke Scale score (19 vs 23; P = .014), shorter duration of infarct swelling (27.6 vs 45.4 hours; P < .001), and higher rate of hemicraniectomy surgery (65.2% vs 28.2%; P =.001) than those without rt-PA treatment. After adjusting for variables in multiple linear regression analysis, rt-PA treatment and an elevated C-reactive protein level were associated with early symptomatic infarct swelling ( P = .014 and P = .041, respectively). The rt-PA treatment was an independent factor related to early symptomatic infarct swelling within 36 hours ( P = .005; odds ratio [OR]: 5.3; confidence interval [CI]: 1.65-17.0) or 48 hours ( P = .009; OR: 16.4; CI: 2.00-134).

Conclusion:

Intravenous rt-PA treatment may hasten the onset of cerebral edema and subsequent cerebral herniation in large MCA territory infarction.
Spoiler definitions and behaviors in the post-network era
Authors: Perks Lisa G , McElrath-Hart Noelle
Published: July 2016

Analysis of survey responses gathered from 92 television time shifters reveals varying attitudes and behaviors toward spoilers. Throughout this essay, we argue that spoiler avoiders embrace post-network era reception practices but use network era norms to evaluate their own experience and regulate the television conversations around them. We see, however, an erosion of those network era norms in people who either use spoilers to enhance their narrative pleasure or who do not actively police television conversations around them. These findings suggest that television conversation norms and individual evaluations of narrative pleasures are slower to evolve than reception patterns. Our study brings convergence culture questions of narrative pleasure, discursive patterns, active audience behaviors, and contested grounds of power to the surface.
Project-based learning: A review of the literature
Authors: Kokotsaki Dimitra , Menzies Victoria , Wiggins Andy
Published: July 2016

Project-based learning (PBL) is an active student-centred form of instruction which is characterised by students’ autonomy, constructive investigations, goal-setting, collaboration, communication and reflection within real-world practices. It has been explored in various contexts and in different phases of schooling, from primary to higher education. The majority of the reviewed studies were based on a quasi-experimental pretest–posttest design with some baseline equivalence established but no random allocation of participants to control and experimental groups, and as a result, a causal link between PBL instruction and positive student outcomes cannot be established with certainty. Modern digital technology, group processes of high quality, teachers’ ability to effectively scaffold students’ learning and provide guidance and support, the balance between didactic instruction with in-depth inquiry methods and well-aligned assessment have been identified in the literature as facilitating factors in the implementation of PBL. The article concludes with six key recommendations considered to be essential for the successful adoption of a PBL approach in the mainstream school setting.
Renal sodium transport in renin-deficient Dahl salt-sensitive rats
Authors: Pavlov Tengis S , Levchenko Vladislav , Ilatovskaya Daria V , Moreno Carol , Staruschenko Alexander
Published: July 2016

Objective:

The Dahl salt-sensitive rat is a well-established model of salt-sensitive hypertension. The goal of this study was to assess the expression and activity of renal sodium channels and transporters in the renin-deficient salt-sensitive rat.

Methods:

Renin knockout (Ren−/−) rats created on the salt-sensitive rat background were used to investigate the role of renin in the regulation of ion transport in salt-sensitive hypertension. Western blotting and patch-clamp analyses were utilized to assess the expression level and activity of Na+ transporters.

Results:

It has been described previously that Ren−/− rats exhibit severe kidney underdevelopment, polyuria, and lower body weight and blood pressure compared to their wild-type littermates. Here we found that renin deficiency led to decreased expression of sodium-hydrogen antiporter (NHE3), the Na+/H+ exchanger involved in Na+ absorption in the proximal tubules, but did not affect the expression of Na-K-Cl cotransporter (NKCC2), the main transporter in the loop of Henle. In the distal nephron, the expression of sodium chloride cotransporter (NCC) was lower in Ren−/− rats. Single-channel patch clamp analysis detected decreased ENaC activity in Ren−/− rats which was mediated via changes in the channel open probability.

Conclusion:

These data illustrate that renin deficiency leads to significant dysregulation of ion transporters.
The Pseudoparadox of Partisan Mapmaking and Congressional Competition
Authors: Goedert Nicholas
Published: July 2016

Why are fewer congressional elections competitive at the district level when the national electoral environment is at its most competitive? This article explores this “pseudoparadox,” and argues that the answer can be found in partisan redistricting. Through an analysis of 40 years of congressional elections, I find that partisan gerrymanders induce greater competitiveness as national tides increase, largely due to unanticipated consequences of waves adverse to the map-drawing party, particularly in seats held by that party. The phenomenon anecdotally coined by Grofman and Brunell as the “dummymander” is thus actually quite common and has significant effects on rates of congressional competition nationally. In contrast, bipartisan maps are shown to induce lower competition, while nonpartisan maps induce higher competition, under all electoral conditions and competitiveness measures. But the effects of partisan gerrymanders on competition, though strong, can only be seen in interaction with short-term national forces.
Complementary and Alternative Medicine Use in Individuals Presenting for Care at a Comprehensive Cancer Center
Authors: Judson Patricia L. , Abdallah Reem , Xiong Yin , Ebbert Judith , Lancaster Johnathan M.
Published: July 2016

Purpose: To define the use of complementary and alternative medicine (CAM) in individuals presenting for care at a comprehensive cancer center. Patients and Methods: A total of 17 639 individuals presenting to an NCI-designated Comprehensive Cancer Center (and consortium sites) completed a questionnaire regarding CAM use. Data were analyzed using the univariate χ2 test to assess CAM use associated with a number of variables, including cancer status, age, gender, marital status, ethnicity, race, employment, and education level. Results: Eighty-seven percent of individuals who completed the CAM survey acknowledged CAM therapy use within the previous 12 months. Of the 5 broad categories of CAM, the most commonly used were biologically based approaches (14 759/17 639 [83.67%]), mind-body interventions (4624/17 485 [26.45%]), manipulative and body-based therapies (3957/17 537 [22.56%]), alternative medical systems (429/15 952 [2.69%]), and energy therapies (270/15 872 [1.7%]). CAM use was more prevalent among women, non-Hispanics, Caucasians, patients 60 to 69 years of age, and those who are married, have a higher level of education, and are employed ( P < .005). Conclusions: This is the largest report of CAM use in individuals presenting for care at a comprehensive cancer center. Our analysis revealed that a very high percentage of patients utilize CAM. Because many of these CAM interventions are not studied in oncology patients, additional research on safety, efficacy, and mechanisms of action are essential. Furthermore, it is important that oncologists understand CAM modalities and counsel their patients about their use.
Synergistic immunologic targets for the treatment of prostate cancer
Authors: Doersch Karen M , Moses Kelvin A , Zimmer Warren E
Published: July 2016

Prostate cancer is a common disease and, while detection and treatment have advanced, it remains a significant cause of morbidity and mortality in men. Research suggests significant involvement of the immune system in the pathogenesis and progression of prostate cancer, indicating that immunologic therapies may benefit patients. Two immunologic factors, interleukin-2 and transforming growth factor-β, may be especially attractive therapeutic targets for prostate cancer. Specifically, an increase in interleukin-2 signaling and a decrease in transforming growth factor-β signaling might help improve immunologic recognition and targeting of tumor cells. The purpose of this review is to highlight the evidence that interleukin-2 and blockade of transforming growth factor-β could be used to target prostate cancer based on current understanding of immune function in the context of prostate cancer. Additionally, current treatments related to these two factors for prostate and other cancers will be used to strengthen the argument for this strategy.
Expression of tyrosine hydroxylase in CD4+ T cells contributes to alleviation of Th17/Treg imbalance in collagen-induced arthritis
Authors: Wang Xiao-Qin , Liu Yan , Cai Huan-Huan , Peng Yu-Ping , Qiu Yi-Hua
Published: July 2016

Tyrosine hydroxylase (TH), a rate-limiting enzyme for the synthesis of catecholamines, is expressed in T lymphocytes. However, the role of T cell-expressed TH in rheumatoid arthritis (RA) is less clear. Herein, we aimed to show the contribution of TH expression by CD4+ T cells to alleviation of helper T (Th)17/regulatory T (Treg) imbalance in collagen-induced arthritis (CIA), a mouse model of RA. CIA was prepared by intradermal injection of collagen type II (CII) at tail base of DBA1/J mice. Expression of TH in the spleen and the ankle joints was measured by real-time polymerase chain reaction and Western blot analysis. Percentages of TH-expressing Th17 and Treg cells in splenic CD4+ T cells were determined by flow cytometry. Overexpression and knockdown of TH gene in CD4+ T cells were taken to evaluate effects of TH on Th17 and Treg cells in CIA. TH expression was upregulated in both the inflamed tissues (spleen and ankle joints) and the CD4+ T cells of CIA mice. In splenic CD4+ T cells, the cells expressing TH were increased during CIA. These cells that expressed more TH in CIA were mainly Th17 cells rather than Treg cells. TH gene overexpression in CD4+ T cells from CIA mice reduced Th17 cell percentage as well as Th17-related transcription factor and cytokine expression and secretion, whereas TH gene knockdown enhanced the Th17 cell activity. In contrast, TH gene overexpression increased Treg-related cytokine expression and secretion in CD4+ T cells of CIA mice, while TH gene knockdown decreased the Treg cell changes. Collectively, these findings show that CIA induces TH expression in CD4+ T cells, particularly in Th17 cells, and suggest that the increased TH expression during CIA represents an anti-inflammatory mechanism.
Can neutrophil/lymphocyte ratio be a novel biomarker of inflammation in children with asthma?
Authors: Nacaroglu Hikmet Tekin , İsgüder Rana , Bent Sultan , Erdem Bahceci Semiha , Ceylan Gökhan , Korkmaz Hüseyin Anıl , Karaman Sait , Unsal Karkıner Canan Sule , Can Demet
Published: July 2016

Neutrophils are known to play a role in airway inflammation and are activated in inflammatory lung diseases such as asthma. In adult studies the neutrophil/lymphocyte ratio (NLR) was found to be a possible biomarker for both airway and systemic inflammation. However, there is a limited understanding regarding NLR in the pediatric age group. To assess NLR as a biomarker for inflammation in pediatric asthma, 54 children admitted to hospital with exacerbation of asthma between March and October 2013 were enrolled into our study. Complete blood counts were obtained during both exacerbation and an asymptomatic period covering at least 3 months after exacerbation. NLRs of the study group during both exacerbation and the asymptomatic period were compared and these two datasets were then compared with the control group. The study group comprised 27 boys (50%) and 27 girls (50%) with a mean age of 120 ± 36 months. Of the total number of patients, 3.7% had mild, 94.4% had moderate, and 1.9% had severe exacerbation of asthma. The NLRs of the study group were found to be significantly higher during exacerbation compared with both the asymptomatic period and the control group ( P = 0.017, P = 0.003). Our study suggests that NLR may be effective and usable measurable biomarker for determining inflammation in cases of pediatric asthma during acute exacerbation period. However, a broad analysis of dependent and independent variables in further prospective studies, is still required.

Trial registration: Not applicable.
Implementing Teacher Evaluation
Authors: Derrington Mary Lynne
Published: July 2016

This case study describes how all leaders in one elementary school focused their collective work implementing a dramatically changed, state-mandated teacher-evaluation system. The article describes how multiple leaders created new professional development structures based on staff feedback and adapted exiting professional development structures to focus on student achievement. Findings indicate that strongly held collective leadership beliefs and values are interwoven with professional development structures in an intertwined lattice of leadership.
Quantitative Research Methods Training in Education Leadership and Administration Preparation Programs as Disciplined Inquiry for Building School Improvement Capacity
Authors: Bowers Alex J.
Published: July 2016

The quantitative research methods course is a staple of graduate programs in education leadership and administration. Historically, these courses serve to train aspiring district and school leaders in fundamental statistical research topics. This article argues for programs to focus as well in these courses on helping aspiring leaders develop skills as practitioner-scholars, including deepening their practice around data analytics, providing opportunities to read and evaluate peer-reviewed research, analyzing data using current methods, and applying findings to facilitate building evidence-based improvement cycles in their schools. Additional data leadership training should be offered for the practicing administrator, educational quantitative analyst, research specialist, and district data scientist.
When Meat Gets Personal, Animals’ Minds Matter Less
Authors: Piazza Jared , Loughnan Steve
Published: July 2016

Why are many Westerners outraged by dog meat, but comfortable with pork? This is particularly puzzling, given strong evidence that both species are highly intelligent. We suggest that although people consider intelligence a key factor in determining animals’ moral status, they disregard this information when it is self-relevant. In Study 1, we show that intelligence plays a major role in the moral concern afforded to animals in the abstract. In Study 2, we manipulated the intelligence of three animals—pigs, tapirs, and a fictional animal—and find that only for pigs does this information not influence moral standing. Finally, in Study 3, we show that people believe that learning about pig intelligence will lead to high levels of moral concern, yet when they themselves learn about pig intelligence, moral concern remains low. These findings demonstrate an important, predictable inconsistency in how people think about minds and moral concern.
Differential protection of black-seed oil on econucleotidase, cholinesterases and aminergic catabolizing enzyme in haloperidol-induced neuronal damage of male rats
Authors: Akintunde Jacob K. , Irechukwu C. Abigail
Published: July 2016

Background:

The antipsychotic, haloperidol, is extremely efficient in the treatment of schizophrenia but its application is constrained because of irreversible adverse drug reactions. Hence, in this study, we investigate the differential effects of black seed oil on cholinesterase [acetylcholinesterase (AChE) and butrylcholinesterase (BuChE), ectonucleotidase (5′-nucleotidase), lactate dehydrogenase (LDH) and monoamine oxidase (MAO)] activities and relevant markers of oxidative stress in the cerebrum of haloperidol-induced neuronal-damaged rats.

Methods:

The animals were divided into six groups (n = 10): normal control rats; haloperidol-induced rats: induced rats were pre-, co- and post-treated with black-seed oil respectively, while the last group was treated with extract oil only. The treatment was performed via oral administration and the experiment lasted 14 days.

Results:

The results revealed an increase in 5I nucleotidase, a marker of adenosine triphosphate (ATP) and adenosine monophosphate (AMP) hydrolysis, as well as AChE, BuChE and MAO activities, with concomitant decrease in LDH activity of cerebrum in induced rats when compared with controls. Also, administration of haloperidol caused systemic oxidative damage and adverse histopathological changes in neuronal cells, indications of mental disorder. The differential treatments with black-seed oil prevented these alterations by increasing LDH and decreasing 5I nucleotidase, AChE, BuChE and MAO activities in the cerebrum. Essential oil post-treatment is most efficacious in reversing haloperidol-induced neuronal damage in rat; followed by pre- and cotreatment, respectively.

Conclusions:

We concluded that essential black-seed oil enhanced the wellness of aminergic, purinergic and cholinergic neurotransmissions of haloperidol-induced neuronal damage in rats.
Temporal trends in the use of antidiabetic medicines: a nationwide 9-year study in older people living in New Zealand
Authors: Nishtala Prasad S. , Salahudeen Mohammed Saji
Published: July 2016

Background:

The global burden of diabetes is increasing worldwide. The aim of the study was to investigate the trends in use of antidiabetic medicines among older New Zealanders between 2005 and 2013, and to perform a separate analysis by age, sex, ethnicity, district health board domicile and socioeconomic deprivation index.

Methods:

The study population included individuals’ aged 65 years and older living in New Zealand (NZ) captured in the pharmaceutical collections. Repeated cross-sectional analysis of population-level dispensing data was conducted from 1 January 2005 to 31 December 2013. Linear regression model using a gamma link function was used to estimate prevalence ratios and trends between 2005 and 2013. The main outcome measure was the prevalence of antidiabetic medicines in older New Zealanders.

Results:

The prevalence of antidiabetic medicines in older New Zealanders increased by 17.6% between 2005 and 2013. Individuals in the 70–74 age group had the highest utilization of each of the classes of antidiabetic medicines and those aged ⩾85 had the lowest utilization. Among the antidiabetic class of medicines, utilization of sulfonylureas was highest and alpha-glucosidase inhibitors the least. The utilization of thiazolidinediones increased over the study period. In 2013, insulin isophane and insulin glargine were the most common insulin analogues used. Insulin use was high in those aged ⩾85 years across the entire study period. The utilization of metformin increased gradually throughout the study period (by 43.9% in 2013 compared with 2005).

Conclusion:

This population-level study showed an increase in utilization of antidiabetic medicines in older people in NZ from 2005 to 2013; however, the increase does not seem to parallel the proportional increase in prevalence of diabetes for the study period. Improving access to newer antidiabetic medicines in line with emerging evidence should be a consideration for decision makers.