bluuebunny/crossref_metadata_2025 huggingface dataset:
Host Specialisation, Immune Cross-Reaction and the Composition of Communities of Co-circulating Borrelia Strains
Authors: Adams Ben , Walter Katharine S , Diuk-Wasser Maria A.
Published: May 2021

We use mathematical modelling to examine how microbial strain communities are structured by the host specialisation traits and antigenic relationships of their members. The model is quite general and broadly applicable, but we focus on Borrelia burgdorferi, the Lyme disease bacterium, transmitted by ticks to mice and birds. In this system, host specialisation driven by the evasion of innate immunity has been linked to multiple niche polymorphism, while antigenic differentiation driven by the evasion of adaptive immunity has been linked to negative frequency dependence. Our model is composed of two host species, one vector, and multiple co-circulating pathogen strains that vary in their host specificity and their antigenic distances from one another. We explore the conditions required to maintain pathogen diversity. We show that the combination of host specificity and antigenic differentiation creates an intricate niche structure. Unequivocal rules that relate the stability of a strain community directly to the trait composition of its members are elusive. However, broad patterns are evident. When antigenic differentiation is weak, stable communities are typically composed entirely of generalists that can exploit either host species equally well. As antigenic differentiation increases, more diverse stable communities emerge, typically around trait compositions of generalists, generalists and very similar specialists, and specialists roughly balanced between the two host species.
Generation of annotated multimodal ground truth datasets for abdominal medical image registration
Authors: Bauer Dominik F. , Russ Tom , Waldkirch Barbara I. , Tönnes Christian , Segars William P. , Schad Lothar R. , Zöllner Frank G. , Golla Alena-Kathrin
Published: May 2021

Purpose

Sparsity of annotated data is a major limitation in medical image processing tasks such as registration. Registered multimodal image data are essential for the diagnosis of medical conditions and the success of interventional medical procedures. To overcome the shortage of data, we present a method that allows the generation of annotated multimodal 4D datasets.

Methods

We use a CycleGAN network architecture to generate multimodal synthetic data from the 4D extended cardiac–torso (XCAT) phantom and real patient data. Organ masks are provided by the XCAT phantom; therefore, the generated dataset can serve as ground truth for image segmentation and registration. Realistic simulation of respiration and heartbeat is possible within the XCAT framework. To underline the usability as a registration ground truth, a proof of principle registration is performed.

Results

Compared to real patient data, the synthetic data showed good agreement regarding the image voxel intensity distribution and the noise characteristics. The generated T1-weighted magnetic resonance imaging, computed tomography (CT), and cone beam CT images are inherently co-registered. Thus, the synthetic dataset allowed us to optimize registration parameters of a multimodal non-rigid registration, utilizing liver organ masks for evaluation.

Conclusion

Our proposed framework provides not only annotated but also multimodal synthetic data which can serve as a ground truth for various tasks in medical imaging processing. We demonstrated the applicability of synthetic data for the development of multimodal medical image registration algorithms.
Inclusion of forestry offsets in emission trading schemes: insights from global experts
Authors: Shrestha Anil , Eshpeter Sarah , Li Nuyun , Li Jinliang , Nile John O. , Wang Guangyu
Published: May 2021

Emissions trading schemes (ETSs) have been a central component of international climate change policies, as a carbon pricing tool to achieve emissions reduction targets. Forest carbon offset credits have been leveraged in many ETSs to efficiently meet emission reduction targets, yet there is little knowledge about the perceptions, experiences, and challenges associated with the forest carbon offsetting in existing and pilot ETS. Given that the future inclusion of forest carbon offset in ETS management activities and policies will require strong support and acceptability among the institutions and experts involved in ETS, this study explores the experiences and lessons learned with 16 globally engaging experts representing major existing ETSs (North America, Europe, and New Zealand) and Chinese pilot ETSs towards the inclusion of forestry offsets, major concerns and challenges with existing implementation models. Findings revealed that many respondents particularly from North America, New Zealand, and Chinese pilot systems portrayed positive attitudes toward the inclusion of forestry carbon offsets and its role in contributing to a viable ETS, while European experts were not supportive. Respondents cited leakage, permanence, additionality, and monitoring design features as the major challenges and concerns that inhibit the expansion and inclusion of forest carbon offsetting. Respondents from Chinese pilot schemes referenced a unique set of challenges related to implementation, including the increasing cost of afforestation and reforestation projects, the uncertainty in the future supply and demand for their national Certified Emissions Reduction (CER) scheme and landowner engagement. Existing and future ETSs should learn from and address the challenges experienced by global experts and carbon pricing mechanisms to design, evaluate, or enhance their forest carbon offset programs for an effective and viable system that successfully contributes to GHG mitigation practices globally. We recommend inclusion of forest carbon offsets at the early stages of ETS improves the perceptions and experience of policy makers and practitioners toward the success and potential of forestry offsets in ETS ensuring familiarity and confidence in the mechanism.
Imaging diagnosis of radial head fractures—evaluation of plain radiography vs. CT scans
Authors: Zhao Zhenhua , Lyu Yiming , Leschinger Tim , Wegmann Kilian , Müller Lars Peter , Hackl Michael
Published: May 2021

Background

Radial head fractures represent a common pathology that can cause permanent disability, especially if not treated correctly. Plain radiographs as well as computed tomography (CT) scans represent important diagnostic measures. The specific differences between these two imaging modalities with regard to diagnosis of radial head fractures have not been evaluated to date.

Objective

This study aimed to compare estimations of fracture classification, percentage of articular fracture involvement, and fragment sizes through plain radiography with CT scan evaluations.

Methods

A total of 52 consecutive cases of isolated radial head fractures with plain radiographs and CT scans were evaluated retrospectively. Two observers analyzed the fracture classification according to Mason, the percentage of articular fracture involvement, and the size of the largest fracture fragment by means of CT. Three trauma surgeons estimated these parameters through blinded plain radiographs. Intra- and inter-observer reliability were evaluated.

Results

The CT scan evaluations showed high intra- and inter-observer reliability without significant differences between the two observers. X‑ray estimations of fracture classifications showed only fair agreements. Moreover, the estimations of articular fracture involvement and fragment sizes differed significantly from the CT scan evaluations. While the fragment size tended to be underrated, the articular involvement tended to be overrated.

Conclusion

This study shows that plain radiographs often provide unreliable information regarding classification, articular involvement, and fragment sizes of radial head fractures. When in doubt, an additional CT scan should be carried out to assess the injury in greater detail.
A measurement error Rao–Yu model for regional prevalence estimation over time using uncertain data obtained from dependent survey estimates
Authors: Burgard Jan Pablo , Krause Joscha , Morales Domingo
Published: May 2021

The assessment of prevalence on regional levels is an important element of public health reporting. Since regional prevalence is rarely collected in registers, corresponding figures are often estimated via small area estimation using suitable health data. However, such data are frequently subject to uncertainty as values have been estimated from surveys. In that case, the method for prevalence estimation must explicitly account for data uncertainty to allow for reliable results. This can be achieved via measurement error models that introduce distribution assumptions on the noisy data. However, these methods usually require target and explanatory variable errors to be independent. This does not hold when data for both have been estimated from the same survey, which is sometimes the case in official statistics. If not accounted for, prevalence estimates can be severely biased. We propose a new measurement error model for regional prevalence estimation that is suitable for settings where target and explanatory variable errors are dependent. We derive empirical best predictors and demonstrate mean-squared error estimation. A maximum likelihood approach for model parameter estimation is presented. Simulation experiments are conducted to prove the effectiveness of the method. An application to regional hypertension prevalence estimation in Germany is provided.
Postmortem diagnostics of assumed suicidal food anaphylaxis in prison: a unique case of anaphylactic death due to peach ingestion
Authors: Tambuzzi Stefano , Gentile Guendalina , Boracchi Michele , Di Candia Domenico , Bianchi Rachele , Zoja Riccardo
Published: May 2021

Suicidal ingestion of food which the victim is aware they are allergic to is an exceptional occurrence in the forensic field. To the best of our knowledge, no cases of suicidal food anaphylaxis have been reported to date. Therefore we present the first case described in the literature. A 30-year-old prisoner was found dead inside his cell with the remains of a peach remains next to his body, and a handwritten farewell note in his pocket. The autopsy revealed only non-specific findings, while laboratory investigations (serological, toxicological, histological, and immunohistochemical) played a pivotal role in determing the cause and manner of death. In particular, a high titer of both total and specific IgE antibodies was detected, as well as an increase of the tryptase level in cadaveric blood. Moreover, a massive concentration of salicylates was measured in the gastric contents. Microscopically, cellular residues characterized by a vegetal structure were observed in the gastric contents and elements suggestive of mast cells were detected in the glottis, lungs, and myocardium. The immunohistochemical investigation with anti-CD117 and anti-tryptase antibodies showed positivity for mast cells, some of which appeared degranulated. Such findings were entirely consistent with an acute systemic anaphylactic reaction triggered by allergy. Therefore, the prisoner’s death was attributed to self-induced food anaphylaxis caused by the ingestion of peaches. This conclusion was achieved based only on circumstantial data, anamnestic information, autopsy findings, and multiple laboratory results. This integrated approach should be used to pursue a post-mortem diagnosis of anaphylaxis.
G-codes, self-dual G-codes and reversible G-codes over the ring ${\mathscr{B}}_{j,k}$
Authors: Dougherty S. T. , Gildea Joe , Korban Adrian , Şahinkaya Serap
Published: May 2021

In this work, we study a new family of rings, ${\mathscr{B}}_{j,k}$

B

j
,
k

, whose base field is the finite field ${\mathbb {F}}_{p^{r}}$

F

p

r

. We study the structure of this family of rings and show that each member of the family is a commutative Frobenius ring. We define a Gray map for the new family of rings, study G-codes, self-dual G-codes, and reversible G-codes over this family. In particular, we show that the projection of a G-code over ${\mathscr{B}}_{j,k}$

B

j
,
k

to a code over ${\mathscr{B}}_{l,m}$

B

l
,
m

is also a G-code and the image under the Gray map of a self-dual G-code is also a self-dual G-code when the characteristic of the base field is 2. Moreover, we show that the image of a reversible G-code under the Gray map is also a reversible $G^{2^{j+k}}$

G

2

j
+
k

-code. The Gray images of these codes are shown to have a rich automorphism group which arises from the algebraic structure of the rings and the groups. Finally, we show that quasi-G codes, which are the images of G-codes under the Gray map, are also Gs-codes for some s.
Self-serving social strategies: A systematic review of social cognition in narcissism
Authors: Eddy Clare M.
Published: May 2021

Narcissistic Personality Disorder is characterised by inflated self-importance, an excessive need for admiration, and a lack of empathy. The interpersonal difficulties associated with narcissistic personality may be becoming more widespread given its increasing prevalence within the general population. This systematic review investigated the relationship between narcissistic personality traits and social cognition (i.e. theory of mind; emotion recognition; empathy; emotional intelligence) in clinical and non-clinical samples. Cognitive empathy (i.e. perspective taking) appears unlikely to be impaired, while affective empathy (relating to another’s emotion state) may be reduced in association with narcissism. Those with grandiose narcissism rate their empathic skills more highly than those with vulnerable narcissism, but concurrent administration of objective measures is rare, limiting insight into the validity of self-ratings. Rather than deficits in aspects of social cognition, the overall pattern could reflect motivation, or advantageous use of social cognitive skills to serve the self. Indeed, interpersonal strategies associated with narcissism (e.g. deception; manipulation) suggest the application of understanding another’s beliefs or desires in the context of low empathy. Further research should seek to explore performance on a wider range of emotion recognition and theory of mind tasks, and whether characteristics such as excessive jealousy and paranoia could reflect hyper-mentalizing.
Shared humanity, awareness of socio-economic privilege, and classism during the pandemic as predictors of supporting equal socio-economic policies
Authors: Uluğ Özden Melis , Solak Nevin , Kanık Betül
Published: May 2021

The coronavirus pandemic has caused unemployment to skyrocket, exposed the longstanding inequalities in health care services and working conditions, and mainly affected the poor in different parts of the world. In the current study, we focus on social identity and social class-related factors that are critical during the pandemic to gain insights into what predicts support for policies favoring economic equality in the post-pandemic period. We argue that to the extent that individuals 1) identify with all humanity during the pandemic, 2) are aware of their socio-economic status-based privilege, 3) do not hold classist attitudes, they would support policies favoring economic equality. In Study 1, survey data from 1212 participants in Turkey were analyzed by means of hierarchical linear regression analysis. The findings showed that stronger identification with all humanity, higher awareness of socio-economic status-based privilege, and less endorsement of classist attitudes predict more support for socio-economic equality policies in the post-pandemic period, after controlling for socio-demographic and socio-political characteristics of participants. Study 2 (N = 212) replicated the findings in a different context, namely the U.S. Our findings extend previous studies by showing the importance of a global identity, such as shared human identity, in the ongoing and potentially in the aftermath of the pandemic. In addition, our findings highlight the joint contributions of socio-economic factors such as classist attitudes and awareness of class-based privilege to the support for socio-economic policies.
The effects of app-based mindfulness practice on the well-being of university students and staff
Authors: Lahtinen Oskari , Aaltonen Jenni , Kaakinen Johanna , Franklin Lena , Hyönä Jukka
Published: May 2021

Mental health problems like anxiety, depression, and stress have been increasing in many countries and the 2020 COVID-19 pandemic has further exacerbated their toll. Mindfulness-based interventions have been shown to provide evidence-based treatments for anxiety and depression, and accumulating evidence is emerging in support of using mindfulness apps yielding small-to-moderate treatment effects. The study was a 4-week randomized controlled trial with 561 university students and staff as participants, divided into a treatment group (mindfulness app) and an active control group (psychoeducational online content). Depression, anxiety, and stress were evaluated as primary study outcomes. Saliva cortisol samples were also collected from a subgroup of the treatment arm (n = 29). Using the mindfulness app for four weeks resulted in small reductions in stress (d = .16), and depression (d = .16). Attrition was 28.0%. Subjects who practiced more did not experience additional improvement in wellbeing. Mindfulness apps offer modest but clear benefits to users in terms of improved mental health. They present a promising supplement to traditional mental health services.
ESMO 2020: highlights in breast cancer
Authors: Bartsch Rupert
Published: May 2021

Despite the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, results of several pertinent studies in the field of breast cancer (BC) were presented in a virtual format at the 2020 European Society of Medical Oncology (ESMO) Congress. Early results of the MonarchE trial investigating the addition of the cyclin-dependent kinase (CDK) 4/6 inhibitor abemaciclib to standard adjuvant endocrine therapy indicated a lower recurrence rate in the combination group in a high-risk population of patients with early stage hormone receptor (HR)-positive/HER2-negative BC. In contrast, the PALLAS study evaluating adjuvant palbociclib could not confirm these results. Subtle differences in the respective trial populations, a higher discontinuation rate in PALLAS, or substance-specific differences may be responsible. In HER2-positive early stage BC, long-term results of the ADAPT-TP trial support the notion that chemotherapy-free treatment may be possible in a subset of patients with favourable response to HER2-directed therapy without compromising long-term outcome. The phase III IMpassion031 trial evaluated the addition of atezolizumab to neoadjuvant anthracycline/taxane-containing chemotherapy in triple-negative BC (TNBC). A significant improvement in terms of pathologic complete remission rate was observed but data concerning long-term outcome must be awaited. Final overall survival (OS) analysis of IMpassion130 confirmed the clinically relevant OS improvement observed with the addition of atezolizumab to first-line nab-paclitaxel in metastatic PD-L1 positive TNBC. In contrast, no benefit was observed with the addition of atezolizumab to solvent-based paclitaxel in a similar population. This contradiction is commonly explained by the need for corticosteroid co-medication with conventional paclitaxel, but the exact reason remains poorly understood. Antibody–drug conjugates (ADCs) have been successfully established in HER2-positive breast cancer; in TNBC, the phase III ASCENT trial compared the ADC sacituzumab govitecan with chemotherapy by physician’s choice in pretreated metastatic patients. A significant improvement in terms of progression-free survival and OS was observed rendering this drug a potential novel standard in this patient population.
Evaluation of the ability of the Clinical Treatment Score at 5 years (CTS5) compared to other risk stratification methods to predict the response to an extended endocrine therapy in breast cancer patients
Authors: Villasco Andrea , Accomasso Francesca , D’Alonzo Marta , Agnelli Francesca , Sismondi Piero , Biglia Nicoletta
Published: May 2021

Purpose

Extension of adjuvant endocrine therapy (ET) reduces the risk of recurrence in women diagnosed with ER-positive breast cancers, but a significant benefit is unlikely to happen to all individual patients. This study is aimed at evaluating the ability of different clinical late distant recurrence (LDR) risk stratification methods and in particular the clinical treatment score at 5 years (CTS5) to predict the response to extended adjuvant ET.

Methods

783 patients diagnosed with ER+ BC between 1988 and 2014 at Umberto I Hospital of Turin, of which 180 received an extended adjuvant ET, were retrospectively selected. They were stratified according to pT, pN, disease stage, tumor grade, Ki67 level, progesterone receptor status and CTS5. The primary endpoint was LDR rate. LDR rates according to ET duration were confronted in each subgroup.

Result

The median duration of extended ET was 7 years (6–10). Median follow-up from diagnosis was 9 years (6–26). Retrospective risk stratification according to tumor size, nodal status, disease stage, tumor grade, Ki67 level, and progesterone receptor status did not appear to be able to predict the response to extended ET. In the CTS5 high-risk subgroup instead, the risk of developing an LDR was significantly lower in the patients who underwent extended ET compared to standard ET (HR 0.37, 95% CI 0.15–0.91), while no significant benefit was demonstrated for low and intermediate-risk patients.

Conclusions

Risk stratification according to CTS5 appeared to be predictive of the response to extended endocrine therapy in our population of real-life pre and postmenopausal patients.
Identification of lysosome‐targeting drugs with anti‐inflammatory activity as potential invasion inhibitors of treatment resistant HER2 positive cancers
Authors: Hansen Malene Bredahl , Postol Maria , Tvingsholm Siri , Nielsen Inger Ødum , Dietrich Tiina Naumanen , Puustinen Pietri , Maeda Kenji , Dinant Christoffel , Strauss Robert , Egan David , Jäättelä Marja , Kallunki Tuula
Published: May 2021

Purpose

Most HER2 positive invasive cancers are either intrinsic non-responsive or develop resistance when treated with 1st line HER2 targeting drugs. Both 1st and 2nd line treatments of HER2 positive cancers are aimed at targeting the HER2 receptor directly, thereby strongly limiting the treatment options of HER2/ErbB2 inhibition resistant invasive cancers.

Methods

We used phenotypic high throughput microscopy screening to identify efficient inhibitors of ErbB2-induced invasion using 1st line HER2 inhibitor trastuzumab- and pertuzumab-resistant, p95-ErbB2 expressing breast cancer cells in conjunction with the Prestwick Chemical Library®. The screening entailed a drug’s ability to inhibit ErbB2-induced, invasion-promoting positioning of lysosomes at the cellular periphery, a phenotype that defines their invasiveness. In addition, we used high throughput microscopy and biochemical assays to assess the effects of the drugs on lysosomal membrane permeabilization (LMP) and autophagy, two features connected to cancer treatment. Using 2nd line HER2 inhibitor lapatinib resistant 3-dimensional model systems, we assessed the effects of the drugs on ErbB2 positive breast cancer spheroids and developed a high-throughput invasion assay for HER2 positive ovarian cancer organoids for further evaluation.

Results

We identified Auranofin, Colchicine, Monensin, Niclosamide, Podophyllotoxin, Quinacrine and Thiostrepton as efficient inhibitors of invasive growth of 2nd line HER2 inhibitor lapatinib resistant breast cancer spheroids and ovarian cancer organoids. We classified these drugs into four groups based on their ability to target lysosomes by inducing autophagy and/or LMP, i.e., drugs inducing early LMP, early autophagy with late LMP, late LMP, or neither.

Conclusions

Our results indicate that targetable lysosome-engaging cellular pathways downstream of ErbB2 contribute to invasion. They support lysosomal trafficking as an attractive target for therapy aiming at preventing the spreading of cancer cells. Since these drugs additionally possess anti-inflammatory activities, they could serve as multipurpose drugs simultaneously targeting infection/inflammation and cancer spreading.
Easy Is Not Always Good – The Fragmented System for Adjudication of Unitary Trade Marks and Designs
Authors: Kur Annette
Published: May 2021

While the creation and still outstanding implementation of the Unified Patent Jurisdiction system continue to cause contentious debates among academics and practitioners, the system introduced in the early 1990s for adjudication of conflicts concerning unitary trade marks (and, later on, unitary design rights) had the charm of simplicity. Building on the national court systems instead of providing for a genuine EU judiciary, the scheme could easily be fitted into existing structures. On the other hand, the imperfect, limping character of the system creates issues inter alia concerning international jurisdiction and applicable law. Furthermore, attributing jurisdiction in infringement litigation to separate national court hierarchies may jeopardize the coherence of the system. While the prospects for reform may be dim insofar as the system in its entirety is concerned, the detrimental effects of fragmentation could be overcome at least to some extent by creating a unitary catalogue of sanctions.
Ethnic Identity in Transition: the Potential Impact of Ethnicity on Chronic Illness’ Medication Adherence in Post-Soviet Country
Authors: Lubi Kadi , Raal Ain , Taba Pille
Published: May 2021

Previously, it has been shown that factors like ethnicity and proficiency of state’s official language not only influence self-management abilities and medication adherence but may also indicate the level of trust in physicians, medication, and healthcare system. This research aims to examine the potential impact of ethnicity on medication adherence based on the example of a post-Soviet country. The research was carried out as a quantitative survey among 303 hypertension and type 2 diabetes patients in Estonia, involving participants from ethnic majority and minority. Research was conducted in community pharmacies and data analysed statistically with SPSS. The findings were opposite to previous research. Although members of the ethnic minority used less illness-related sources, these sources relied more on evidence-based medicine compared to the ethnic majority. Because of this, medication adherence was also slightly higher for the ethnic minority compared to the majority. Therefore, these findings indicate trust in medical authorities, their decisions, and recommendations. There was a statistically significant relationship between general and illness-related information-seeking activity; however, medication adherence was not related to information-seeking activity. The research outlines that in addition to ethnolinguistic aspect, also potential cultural influence might determine the trust in medicine and medication adherence.
HIV, Human Rights and Migration: Narratives of HIV-Positive Asylum Seekers in Scotland
Authors: Palattiyil George , Sidhva Dina
Published: May 2021

Political instability, armed unrest, religious intolerance, human rights violations, ethnic conflict and environmental disasters that threaten one’s life, displace people and often compel them to seek asylum elsewhere. Over the years, the UK has been a major recipient of asylum seekers, some of whom have come to Scotland, especially since 2000, and among these there are a number who present health issues including being HIV-positive. HIV-positive asylum seekers experience poverty, isolation, vulnerability, stigma and discrimination, which when coupled with a lack of appropriate medical care and support, have the potential of adding another layer on the denial of fundamental human rights and further stigmatising people who are already fleeing circumstances threatening their very existence. This paper discusses findings from a recent study that examined the lived experiences of HIV-positive asylum seekers since their arrival in Scotland. A flexible qualitative research design that included in-depth interviews that used life history and a phenomenological approach was adopted. Underpinned by ethics approval, nineteen HIV-positive Black African asylum seekers were recruited through third sector organisations in Glasgow, Scotland. Additional data were gathered from two emotive and discursive focus group meetings. Findings were developed using narrative analysis. The accounts of the asylum seekers reflect continued fear of stigma in the face of HIV disclosure, but also pervasive poverty and inequality. Their experiences include denial of rights to family and security, fear of being detained and deported, denial of appropriate medical care, symptoms of post-traumatic disorder and the culturally insensitive and sometimes inhumane attitude of the UK Immigration Agency. These themes depict an everyday struggle in a context of denial of support and risk of potential deportation to a country where HIV treatment is limited or inaccessible. Their narratives also attest to the life-giving, unstinting care and support they receive from a handful of voluntary agencies and one specialist HIV clinic in Scotland. The findings from this study raise issues for a debate about the treatment of HIV-positive asylum seekers in Scotland. Poverty, inequality, stigma and discrimination continue to pose difficulties in accessing care and treatment and wider community integration. Often treated in a piecemeal and ‘service-siloed’ fashion, the needs and human rights of HIV-positive asylum seekers require a greater, more holistic practice and policy attention.
Homotopical decompositions of simplicial and Vietoris Rips complexes
Authors: Chachólski Wojciech , Jin Alvin , Scolamiero Martina , Tombari Francesca
Published: May 2021

Motivated by applications in Topological Data Analysis, we consider decompositions of a simplicial complex induced by a cover of its vertices. We study how the homotopy type of such decompositions approximates the homotopy of the simplicial complex itself. The difference between the simplicial complex and such an approximation is quantitatively measured by means of the so called obstruction complexes. Our general machinery is then specialized to clique complexes, Vietoris-Rips complexes and Vietoris-Rips complexes of metric gluings.
In silico virtual screening of lead compounds for major antigenic sites in respiratory syncytial virus fusion protein
Authors: Mathew Shilu , Taleb Sara , Eid Ali Hussein , Althani Asmaa A. , Yassine Hadi M.
Published: May 2021

Human respiratory syncytial virus (RSV) is a leading ubiquitous respiratory pathogen in newborn infants, young children, and the elderly, with no vaccine available to date. The viral fusion glycoprotein (RSV F) plays an essential role in the infection process, and it is a primary target of neutralizing antibodies, making it an attractive site for vaccine development. With this in view, there is a persistent need to identify selective antiviral drugs against RSV, targeting the major antigenic sites on the F protein. We aimed to conduct a robust in silico high-throughput drug screening of one million compounds to explore potential inhibitors that bind the major antigenic site Ø and site II on RSV F protein, which are the main target of neutralizing antibodies (NAb). We utilized the three-dimensional crystallographic structure of both antigenic site Ø on pre-F and antigenic II on post-F to screen for potential anti-RSV inhibitors. A library of one million small compounds was docked to explore lead binders in the major antigenic sites by using virtual lab bench CLC Drug Discovery. We also performed Quantitative Structure-Activity and Relationship (QSAR) for the lead best binders known for their antiviral activity. Among one million tested ligands, seven ligands (PubChem ID: 3714418, 24787350, 49828911, 24802036, 79824892, 49726463, and 3139884) were identified as the best binders to neutralizing epitopes site Ø and four ligands (PubChem ID: 865999, 17505357, 24802036, and 24285058) to neutralizing epitopes site II, respectively. These binders exhibited significant interactions with neutralizing epitopes on RSV F, with an average of six H bonds, docking energy of − 15.43 Kcal·mol−1, and minimum interaction energy of − 7.45 Kcal·mol−1. Using in silico virtual screening, we identified potential RSV inhibitors that bind two major antigenic sites on the RSV F protein. Using structure-based design and combination-based drug therapy, identified molecules could be modified to generate the next generation anti-RSV drugs.
New dilemmas, old problems: advances in data analysis and its geoethical implications in groundwater management
Authors: de Oliveira Ferreira Silva César , Matulovic Mariana , Lilla Manzione Rodrigo
Published: May 2021

Groundwater governance uses modeling to support decision making. Therefore, data science techniques are essential. Specific difficulties arise because variables must be used that cannot be directly measured, such as aquifer recharge and groundwater flow. However, such techniques involve dealing with (often not very explicitly stated) ethical questions. To support groundwater governance, these ethical questions cannot be solved straightforward. In this study, we propose an approach called “open-minded roadmap” to guide data analytics and modeling for groundwater governance decision making. To frame the ethical questions, we use the concept of geoethical thinking, a method to combine geoscience-expertise and societal responsibility of the geoscientist. We present a case study in groundwater monitoring modeling experiment using data analytics methods in southeast Brazil. A model based on fuzzy logic (with high expert intervention) and three data-driven models (with low expert intervention) are tested and evaluated for aquifer recharge in watersheds. The roadmap approach consists of three issues: (a) data acquisition, (b) modeling and (c) the open-minded (geo)ethical attitude. The level of expert intervention in the modeling stage and model validation are discussed. A search for gaps in the model use is made, anticipating issues through the development of application scenarios, to reach a final decision. When the model is validated in one watershed and then extrapolated to neighboring watersheds, we found large asymmetries in the recharge estimatives. Hence, we can show that more information (data, expertise etc.) is needed to improve the models’ predictability-skill. In the resulting iterative approach, new questions will arise (as new information comes available), and therefore, steady recourse to the open-minded roadmap is recommended.

Graphic abstract
Applying the Exploration, Preparation, Implementation, Sustainment (EPIS) Framework to Safe Surgery 2020 Implementation in Tanzania's Lake Zone
Authors: Alidina Shehnaz , Zanial Noor , Meara John G. , Barash David , Buberwa Ladislaus , Chirangi Bwire , Hellar Augustino , Kisakye Steve , Mazhiqi Adelina , Mnyonyela William , Nyanda Meck P. , Reynolds Cheri , Tinuga Florian , Kapologwe Ntuli A. , Maongezi Sarah
Published: May 2021

BACKGROUND:

Access to safe, high-quality surgical care in sub-Saharan Africa is a critical gap. Interventions to improve surgical quality have been developed, but research on their implementation is still at a nascent stage. We retrospectively applied the Exploration, Preparation, Implementation, Sustainment framework to characterize the implementation of Safe Surgery 2020, a multicomponent intervention to improve surgical quality.

METHODS:

We used a longitudinal, qualitative research design to examine Safe Surgery 2020 in 10 health facilities in Tanzania's Lake Zone. We used documentation analysis with confirmatory key informant interviews (n = 6) to describe the exploration and preparation phases. We conducted interviews with health facility leaders and surgical team members at 1, 6, and 12 months (n = 101) post initiation to characterize the implementation phase. Data were analyzed using the constant comparison method.

RESULTS:

In the exploration phase, research, expert consultation, and scoping activities revealed the need for a multicomponent intervention to improve surgical quality. In the preparation phase, onsite visits identified priorities and barriers to implementation to adapt the intervention components and curriculum. In the active implementation phase, 4 themes related to the inner organizational context—vision for safe surgery, existing surgical practices, leadership support, and resilience—and 3 themes related to the intervention—innovation-value fit, holistic approach, and buy-in—facilitated or hindered implementation. Interviewees perceived improvements in teamwork and communication and intra- and inter-facility learning, and their need to deliver safe surgery evolved during the implementation period.

CONCLUSIONS:

Examining implementation through the exploration, preparation, implementation, and sustainment phases offers insights into the implementation of interventions to improve surgical quality and promote sustainability.
Interaction effects on the conversion corridor of tiltrotor aircraft
Authors: Appleton W. , Filippone A. , Bojdo N.
Published: May 2021

This paper presents an aeromechanics investigation of tiltrotor aircraft through the conversion regime of flight. The effects of the rotors-on-wing, rotors-on-empennage and wing-on-empennage interactions were investigated singularly and collectively to assess their impacts on trim behaviour, performance and conversion boundaries. The rotors-on-wing download was found to be dominant in the prediction of hover and low-speed flight performance and had a degrading effect overall. The fuselage pitch attitude and stick position were found to be significantly affected by the empennage interaction cases throughout the conversion domain. The large flap/flaperon settings used to alleviate the rotor download contributed considerably to the low-speed trim behaviour. The conversion boundaries were found to be insensitive to all the interaction cases, though the min-speed boundary was reduced marginally due to the wing-on-empennage interaction. The results showed that the combined interactions were important factors to accurately predict the trim behaviour and aircraft performance throughout the conversion corridor.
The “Ketu Nation” of Brazilian Candomblé in Historical Context
Authors: Castillo Lisa Earl
Published: May 2021

The Afro-Brazilian religion of Candomblé arose during the Atlantic slave trade and has unmistakable Yorùbá influences. In the city of Salvador, the termnação ketu[Ketu nation] is used among the oldest temples in describing Yorùbá heritage. This has led some scholars to assume that the founders came from the Yorùbá kingdom by that name. This paper critically examines the idea of Kétu origins, taking as a case study the temple Ilê Axé Iyá Nassô Oká, a national historic heritage site in Brazil that is recognized by UNESCO as a site of diasporic memory. The paper shows that the first generations of leadership were dominated by people from Ọ̀yọ́ and that the termketuemerged not as an allusion to ethnic origins but perhaps as a metaphor for a heterogeneous cultural context in which Yorùbá speakers from disparate regions lived in close coexistence.
Precarity and Resistance: A Critique of Martha Fineman's Vulnerability Theory
Authors: Davis Benjamin P. , Aldieri Eric
Published: May 2021

Contemporary feminist theory by and large agrees on criticizing the traditional, autonomous subject and instead maintains a relational, dependent self, but the vocabulary used to describe the latter remains contested. These contestations are seen in comparing the approach of some feminist legal theory, as demonstrated by Martha Fineman, to the approach of some feminist theory that draws on continental philosophy, as demonstrated by Judith Butler. Fineman's concept of vulnerability emphasizes the universality of vulnerability in the human condition, arguing that a “responsive state” is most conducive to producing subjects who are “resilient” in the face of neoliberal pressures. We argue that vulnerability, as an existential as opposed to a political description, is a limited rubric under which to organize against neoliberal forces. Further, we contend that Fineman's rhetoric of resilience risks reiterating a neoliberal logic of individualized self-management. In response, we look to Butler's concept of precarity, which underscores particular social conditions, as opposed to universal ontological vulnerabilities, that debilitate certain subjects. At stake is how we respond to neoliberal forces today: a vocabulary of precarity poses a more effective challenge than one of vulnerability, for it opens onto not merely individual or institutional resilience but grounded, communal resistance.
Evaluation of N95 respirator ultraviolet decontamination and clinical reuse with quantitative fit testing
Authors: Wanner Gregory K. , Ader Douglas , Caplan Richard , Padaki Amit S. , Ravert Debra , Drees Marci
Published: May 2021

The supply of N95 respirators has been severely strained by the coronavirus disease 2019 (COVID-19) pandemic. We used quantitative fit-testing to evaluate 16 participants and 45 respirators through up to 4 rounds of ultraviolet decontamination and clinical reuse. The mean fit-test failure rate was 29.7%, and the probability of failure increased through N95 reuse.
A new cheilostome bryozoan from a dinosaur site in the Upper Cretaceous (Campanian) Judith River Formation of Montana
Authors: Taylor Paul D. , Rogers Raymond R.
Published: May 2021

Few bryozoans have been described from the Cretaceous Western Interior Seaway (WIS), which is consistent with the low diversity of other typically stenohaline groups in this large expanse of relatively shallow marine water. Here we describe a new cheilostome bryozoan,Conopeum flumineumn. sp., based on well-preserved material from the Campanian Judith River Formation of the Upper Missouri River Breaks National Monument in north-central Montana. The new species shows strong morphological similarities withConopeum seurati, a Recent species that is often categorized as brackish, but which is euryhaline and can also be found in marine and stenohaline environments. The new Campanian bryozoan species was found in a locality also containing fragmentary remains of dinosaurs and other terrestrial vertebrates, as well freshwater mollusks and terrestrial plant debris. The sedimentology and facies associations of the fossil-bearing site suggest that the depositional setting was a swamp or tidally influenced fluvial backwater on the Judith River coastal plain. The proximity of the site to the western shoreline of the WIS presumably made it susceptible to occasional marine flooding during storms or extreme tides. Previous occurrences ofConopeumin the Cretaceous of the Western Interior have also been associated with dinosaur remains, corroborating the very nearshore and at times even ‘upstream’ distribution of this euryhaline genus.

UUID:http://zoobank.org/bb1fdc8a-5017-44c5-9251-9e24ef3995e3.
Magnetic nulls in interacting dipolar fields
Authors: Elder Todd , Boozer Allen H.
Published: May 2021

The prominence of nulls in reconnection theory is due to the expected singular current density and the indeterminacy of field lines at a magnetic null. Electron inertia changes the implications of both features. Magnetic field lines are distinguishable only when their distance of closest approach exceeds a distance$\varDelta _d$. Electron inertia ensures$\varDelta _d\gtrsim c/\omega _{pe}$. The lines that lie within a magnetic flux tube of radius$\varDelta _d$at the place where the field strength$B$is strongest are fundamentally indistinguishable. If the tube, somewhere along its length, encloses a point where$B=0$vanishes, then distinguishable lines come no closer to the null than$\approx (a^2c/\omega _{pe})^{1/3}$, where$a$is a characteristic spatial scale of the magnetic field. The behaviour of the magnetic field lines in the presence of nulls is studied for a dipole embedded in a spatially constant magnetic field. In addition to the implications of distinguishability, a constraint on the current density at a null is obtained, and the time required for thin current sheets to arise is derived.
Combined plasma–coil optimization algorithms
Authors: Henneberg S. A. , Hudson S. R. , Pfefferlé D. , Helander P.
Published: May 2021

Combined plasma–coil optimization approaches for designing stellarators are discussed and a new method for calculating free-boundary equilibria for multiregion relaxed magnetohydrodynmics (MRxMHD) is proposed. Four distinct categories of stellarator optimization, two of which are novel approaches, are the fixed-boundary optimization, the generalized fixed-boundary optimization, the quasi-free-boundary optimization, and the free-boundary (coil) optimization. These are described using the MRxMHD energy functional, the Biot–Savart integral, the coil-penalty functional and the virtual casing integral and their derivatives. The proposed free-boundary equilibrium calculation differs from existing methods in how the boundary-value problem is posed, and for the new approach it seems that there is not an associated energy minimization principle because a non-symmetric functional arises. We propose to solve the weak formulation of this problem using a spectral-Galerkin method, and this will reduce the free-boundary equilibrium calculation to something comparable to a fixed-boundary calculation. In our discussion of combined plasma–coil optimization algorithms, we emphasize the importance of the stability matrix.
Adam Smith on Impartial Patriotism
Authors: Elazar Yiftah
Published: May 2021

Scholars have emphasized Adam Smith's critique of the dangers of patriotism, but have not paid close attention to its potential value. This article recovers from Smith's work an attractive model of patriotism without nationalism. The potential value of patriotism lies in inspiring individuals to realize an ideal of impartial beneficence, which consists in overcoming selfishness and other subpolity partialities and in promoting the greater happiness of all fellow citizens. Smith defends virtuous patriotism against strong cosmopolitanism by arguing that a global division of labor, which directs individuals to benefit their compatriots, more effectively serves the interests of humanity than directly trying to promote global happiness. This article illuminates aspects of Smith's work that contrast with the “invisible hand” argument and favor the conscious pursuit of public interest in some contexts. It contributes to recent discussions of patriotism a distinctive way of understanding its relation to impartiality.
What about the teacher?
Authors: Griffiths Carol
Published: May 2021

Given that I have been a teacher of one kind or another for practically all of my working life, starting as a high school English teacher before moving into TESOL (teaching English to speakers of other languages), I would like to suggest (in all modesty, of course!) that I am in a good position to understand the stresses of the job. In this position paper, I would like to try to explain the background to the issues of teacher stress, to identify contemporary problem areas, to suggest some possible ways to address the problems, and also to explain why tackling teacher stress is so important – both for teachers themselves, and also for the other stakeholders, especially the learners. Although this article draws essentially on the experience of language teachers and related literature, many of the issues described could apply to teachers of any subject at any level anywhere, a point that will be taken up again when suggesting areas for further research.