bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Regional Revival on Other Idle Buildings: Pilavoglu Inn
Authors: ÇOBAN Zeynep , HALAÇ Hicran Hanım
Published: July 2023

Ankara Hanlar Bölgesi, 16-17. yüzyılda Osmanlı Devleti’nin önemli ticaret merkezlerinden biri olmuştur. 19.yüzyılda yaşanan siyasi, ekonomik ve doğal afetler sebebiyle önemini yitiren bölge, restorasyon çalışmaları ile tekrar canlanmış
ve kültürel bir turistik merkez haline gelmiştir. Bölgede gerçekleştirilen restorasyon çalışmaları, farklı işlevler ve kullanım alanları sağlayarak bölgeyi zenginleştirmiş ve zaman içinde kullanıcı sayısını artırmıştır. Bu çalışmada,
Hanlar Bölgesi’ndeki gerçekleşen bu canlanmanın, bölgede yarattığı sosyal dinamikler üzerinde durulmuş ve bu yaratılan sosyal dinamiklerin âtıl kalmış Pilavoğlu Han’nın üzerindeki etkileri değerlendirilmiştir. Pilavoğu Han, Cumhuriyet’in
ilk yıllarında cezaevi olarak sonrasında kimsesizlerin konakladığı bir han olarak kullanılmış; 20. yüzyılın sonlarında ise kaybettiği ticari değeri tekrar kazanmıştır. Pilavoğlu Han, günümüzde el sanatları atölyelerinin ve satış
birimlerinin bulunduğu kültürel, sosyal ve ticari etkileşimin kesişim noktası haline gelmiştir. Bu süreçte bölgede yaşanan canlanma ve oluşan yeni dinamikler ile herhangi bir restorasyon işleminden geçmeden kendi kendine örgütlenerek
kullanıcının ilgisini çekmeyi sağlamıştır. Bu çalışmada atölye sahiplerinin münferit tadilatlarıyla ayakta duran Pilavoğlu Han’ın atölye sahipleriyle anket yapılarak mekânların kullanım tarihleri, analizleri ve yapılan müdahaleler
tespit edilmiştir. Âtıl kalmış bir tarihi yapının canlanması ve yaşatılması için yapıyı restore etmenin tek seçenek olmadığı, kullanıcıların mekânı kullanması ve şekillendirmesinin de bir yöntem olduğu sonucuna varılmıştır. Çalışmanın,
benzer durumdaki yapıların canlandırılma sürecinde fikir vermesi ön görülmüştür.
Classical Period in Western Geography: Alexander Von Humboldt and Carl Ritter
Authors: OĞLAKCI Burak , ALİAĞAOĞLU Alpaslan
Published: July 2023

Alexander Von Humboldt ve Carl Ritter, modern-bilimsel özellik kazanmış ve çalışmaları sistematik olarak tatbik edilen bir coğrafya disiplininin ortaya çıkışında yer alan iki önemli şahsiyettir. 1769 yılında doğan ve fiziki coğrafyanın
kurucusu olarak bilinen Humboldt, kendisinden on yıl sonra doğan (1779) ve beşerî coğrafyanın kurucusu sayılan Ritter ile aynı tarihte (1859) ölmüştür. Her ikisi de Alman olan bu araştırmacılar, yaptıkları çalışmalar, coğrafyaya
olan yaklaşımları, metodolojileri, bilimsel-felsefi görüşleri ve diğer birçok unsur sayesinde coğrafya biliminin gelişim tarihinde önemli bir yer edinmişlerdir. Literatür içerisinde iki ismin ayrı ayrı ele alındığı çeşitli çalışmalar
bulunmaktadır. Ancak benzer ve farklı yönlerin karşılaştırmalı olarak sunulduğu ve ikili arasındaki ilişkilerin ele alındığı Türkçe çalışmalar kısıtlıdır. Bu kısıtlılık çalışmanın temel motivasyonunu oluşturmaktadır. Bu doğrultuda
çalışma, literatür tarama yöntemi ile anlatı araştırması türlerinden biri olan biyografi yöntemini kullanarak, Humboldt ve Ritter’in coğrafya bilimine olan katkılarını, benzer ve farklı yönlerini ve ikili arasındaki etkileşimi
içerisinde bulundukları dönem dâhilinde ortaya koymayı amaçlamaktadır. Klasik ya da Erken Modern Coğrafya Dönemi olarak da adlandırılan bu dönemin iki önemli figürü karşılaştırmalı metodoloji, insan dâhil doğanın birliği fikri,
bilgiyi önemini vurgulayarak şekilde organize etme ve diğer birçok noktada birleşse de ikili arasındaki farklılıkların daha fazla olduğu görülmektedir. Nitekim iki isim çalışma alanı, coğrafyayı tanımlama, doğaya yönelik yaklaşım,
çalışma ortamı, seyahat edip etmeme ve diğer birçok yönden farklılık göstermektedir. Son olarak, önceki çalışmalarda pek yer verilmese de Humboldt ve Ritter arasında coğrafya bilimine katkılar sağlayan bilimsel-dostane bir ilişkinin
de var olduğu anlaşılmaktadır.
Metaphor as a Contemporary Art Strategy
Authors: KOÇ Ali , GEÇEN Fahrettin
Published: July 2023

Bu araştırma, çokluk dilbilim ve felsefe dalları tarafından işlenen metafora genelde sanat özelde çağdaş sanat penceresinden bir bakış yöneltir. Sosyal bilim çevreleri (dilbilim, felsefe, sanat, tarih vb.) metaforu ‘geleneksel metafor
yaklaşımı’ ve ‘çağdaş metafor yaklaşımı’ olarak iki ayrı başlıkta değerlendirirler. Öyle ki, bu iki ayrı başlıktan ‘geleneksel metafor yaklaşımı’ Antikite Dönemi’nden (M.Ö. V.-I. yüzyıl) itibaren Modern Dönem’in sonuna kadar olan
2.500 yıllık zaman dilimini; ‘çağdaş metafor yaklaşımı’ ise 1960 sonrasında başlayan ve 1980’lerde hız kazan Postmodern Dönemi ifade eder. Bunlardan ‘geleneksel metafor yaklaşımı’nın 20. yüzyıl başında sosyal bilim çevrelerinde
ortaya atılan ‘yapısalcılık’la; ‘çağdaş metafor yaklaşımı’nın ise Postmodern Dönem’de gündeme gelen ‘yapıbozumculuk’la olan ilgileri dikkat çeker. Bu yüzden Postmodern Dönem’in ‘çağdaş metafor yaklaşımı’nın günümüzde üretilen çağdaş
sanat işleriyle ilgili olduğu ve bu dönem işlerini etkilediği anlaşılır. Öte yandan metaforun, çağdaş sanatçıların çok sayıda kullandığı stratejilerden biri olduğu görülür. Dolayısıyla burada, ‘çağdaş metafor yaklaşımı’ sergileyen
günümüz sanatçılarından ‘iş’lerinde metaforu bir strateji olarak kullanan Amerika’lı William Pope. L (1955-), Malezya’lı Wong Hoy Cheong (1960-), Hindistan’lı Bose Krishnamachari (1963-) ve Filipinler’den Josephine Turalba’nın
(1965-) birer adet çalışması incelenir. Böylelikle, metaforun güncel sanat işi örnekleri üzerinden ‘geleneksel metafor yaklaşımı’ ile olan farkları ortaya çıkarılır. Çağdaş sanatta metafor stratejisini inceleyen bu araştırma, nitel
araştırma ile betimsel araştırma yöntemini kullanır. Sonuçta, çağdaş sanat stratejisi olarak metaforun, geleneksel ‘benzetmeci’ metafor anlayışından farklı olarak kavrama, anlama, içeriğe, gündelik hayatın sıradanlığına ve basitliğe
önem verdiği gözlenir. Metafor olgusuna çağdaş sanat açısından bakan bu araştırmanın sosyal bilimler bağlamında sanat alanyazın dünyasına katkılar sağlayacağı umut edilmektedir.
Evaluation of Project Management Education in Terms of Academic Stress Factors
Authors: GEYLANİ Özlem , GÜNER Aysun Ferrah
Published: July 2023

İnşaat sektörünün beklentilerini karşılayabilmek amacıyla, yönetim içerikli dersler üniversitelerde; mühendislik yönetimi, yapım yönetimi ve proje yönetimi (PM) dersleri ile inşaat mühendisliği ve mimarlık disiplinleri eğitim planlarına
dâhil edilmiştir. Yüksek lisans veya lisans düzeyindeki PM bilgi alanlarını içeren derslerin amacı; öğrencilerin teknik, yönetsel ve kişisel becerilerini geliştirmesine ve sektörde çalışmaya hazır insan kaynağının sağlanmasına
yöneliktir. Proje ekibinde stres yönetimi proje yöneticilerinin sorumluluk alanlarından biri olmakla birlikte, proje ekibindeki insan kaynağı gelişiminin ve projenin başarısı için de önem taşımaktadır. Bu bağlamda, mimarlık fakültelerinde
lisans düzeyinde verilen PM eğitiminde, öğrencilerin akademik stres faktörleri karşısında, gösterdikleri tepkileri anlamlandırabilmek, hem kişisel gelişim açısından hem de dersin içeriğinin, dersi veren öğretim elemanlarının gelişimi
açısından önem arz etmektedir. Araştırmanın tasarımında, Türkiye ve dünya üzerindeki PM eğitimi ve akademik stres faktörlerine yönelik teorik altyapının hazırlanmasının ardından, ilgili konu başlıkları belirlenmiş ve 15 soruluk
çevrimiçi bir anket çalışması hazırlanmıştır. Araştırmacıların üç akademik dönem boyunca PM dersi verdikleri İstanbul’da bir vakıf üniversitesinde düzenledikleri pilot anket çalışmasını takiben, PM dersi alan öğrencilerden 99 adet
geri bildirim elde edilmiştir. Akademik stres faktörlerinin evreni, bu ders ile ilgili çalışma kapsamında belirlenen üç akademik stres faktörü için sınırlandırılmıştır, dersin öğretim elemanı, dersin dili, ders teslimleri için
bir PM yazılımı kullanılmasına yönelik öğrenci görüşleri sorulmuş ve cinsiyet faktörünün stres anında gösterilen tepkiler açısından farklılığı da araştırılmıştır. Elde edilen veriler, 5'li Likert ölçeği üzerinden sorgulanmış, SPSS
(stastical package for the social sciences) paket programı yardımıyla işlenmiş ve araştırma kapsamında önerilen hipotezler sınanmıştır. Son olarak, çalışma bulgularına yönelik tartışma ve öneriler sunularak çalışma tamamlanmıştır.
Determination of Preferences of Participation in Recreation Areas: (Example of Elazig Fethi Sekin and Cip Promenade Areas)
Authors: ŞİMŞEK Abdullah , KIRTEPE Abdurrahman
Published: July 2023

Bu araştırma Elazığ ilinde bulunan Cip ve Şehit Polis Fethi Sekin mesire alanlarına katılım gösteren bireylerin bu alanları tercih etmelerindeki nedenlerin belirlenmesi amacıyla yapılmıştır. Bu bağlamda, mesire alanlarına katılım gösteren
218’i erkek 182’si kadın olmak üzere toplam 400 birey gönüllü olarak katılmıştır. Bu araştırmada katılımcıların sosyo-demografik değişkenler (Cinsiyet, Yaş, Medeni Durum, Aylık Gelir, Eğitim Durumu, Haftalık Spor Yapma Sıklığı
ve Rekreasyon Alanları Tercih Nedeni) ile ilgili bilgiler, araştırmacı tarafından oluşturulan Kişisel Bilgi Formu ile toplanmıştır. Araştırmanın ikinci kısmında ise 24 madde ve 5 faktörden oluşan “Rekreasyon Alanları Tercih Etkenleri
Ölçeği” kullanılmıştır. Katılımcıların tanımlayıcı özelliklerinin incelenmesinde frekans, yüzde, ortalama, standart sapma gibi ölçüler kullanılmıştır. Araştırmada iki grubu karşılaştırmak için, bağımsız iki örnek t-testi ve ikiden
fazla grubu karşılaştırmak için de tek yönlü Anova analizi ve faktör analizi kullanılmıştır. Ölçeğin alt boyutları arasındaki ilişkinin belirlenmesi amacıyla korelasyon analizi kullanılmıştır. Demografik özelliklerin dağılımlarını
göstermek amacıyla frekans tabloları kullanılmıştır. Verilerin bilgisayar ortamına aktarılması istatistiki programlar anlamlılık düzeyi p<0,05 olarak kabul edilmiştir. Araştırma sonucunda, rekreasyon alanlarını tercih etkenleri
arasında en düşük puanların aktivite boyutunda olduğu görülmektedir. Rekreasyon alanlarında yeterli personelin bulunması, sportif çeşitliliğe imkan sağlaması, konum açısından ulaşılabilir olması ve fiziki imkanlar açısından yeterli
olması gibi konularda; yeterli çalışmaların yapılarak bu alanların sürdürülebilir nitelikte düzenlenmesi veya tasarlanması gerekliliği sonucu elde edilmiştir.
Economic Analysis of Marigold (Tagetes erecta L.) cv. Pusa Narangi Gainda the Result under Multiple Organic Manure Treatments
Authors: Gupta Neeraj Kumar , Ngaich K. N. , Pandey Devesh K. , Mishra S. N.
Published: July 2023

The current study, Economic analysis of marigold (Tagetes erecta L.) cv. Pusa Narangi Gainda the result under multiple organic manure treatments was conducted in 2021 and 2022 at the Department of Horticulture, Mansarovar Global University Sehore, Madhya Pradesh.The experiment was designed in R.B.D. with three replications and 13 treatments. Floral yield metrics such as cost of culture, gross returns, and net returns benefit cost ratio, as well as vegetative growth parameters, were all most efficiently boosted by fertilizer. As a result of the use of organic manures, the African marigold shown strong vegetative growth and flower output qualities.
Spatio-Temporal Analysis of Rainfall and Temperature Trends in Maharashtra State, India (Asia)
Authors: Athare Prakash Goraksha , Singh Dharam Raj , Kumar Nalini Ranjan , Jha Girish Kumar , Venkatesh P. , Chakrabarti Bidisha
Published: July 2023

Examining the manifestations and effects of climate change is critically dependent on the spatiotemporal analysis of meteorological variables, particularly in areas where agriculture depends on rainfall. The present study analyses the change in temperature and rainfall using Mann-Kendall and Sen's slope estimator and also identifies the variations in rainfall by using Rainfall Anomaly Index (RAI). The main purpose of this study is to assess the variation in climatic variable (temperature and rainfall) across the regions of Maharashtra over 50 years (1968-2017) which might be helpful to identify strategies that can aid in addressing the consequences of extreme climate events in the future and in formulating appropriate region-specific strategies. The trend of rainfall and temperature series for the kharif and rabi season revealed a significant increasing trend for maximum and minimum temperature, however nonsignificant decreasing trend for kharif and rabi rainfall. The RAI value indicates a relatively a greater number of dry periods in Marathwada and Vidarbha region in comparison to the Konkan, Western Maharashtra and Khandesh. The findings of the study can be useful in developing plans to manage water resources effectively and reduce the adverse impacts of droughts basically in the Marathwada and Vidarbha regions.
Estimates of Genetic Variability, Yield and Quality Traits of Brinjal (Solanum melongena L.)
Authors: Chaudhary Akhil Kumar , Yadav Gulab Chand , Maurya Rajat Kumar , Anjana C. S. , Prajapati Jaswant
Published: July 2023

The present investigation was carried out involving thirty two genotypes of brinjal with a view to estimate the extent of variability, heritability and genetic advance in per cent of mean. The experiment was conducted in Randomized Block Design with three replications during Kharif, 2020-21. The analysis of variance revealed that mean sum of squares due to genotypes were highly significant for all the traits indicating ample variation among the genotypes for all the traits. High magnitudes of PCV and GCV were observed for some quality traits like non-reducing sugar (34.80% and 34.69%) and ascorbic acid (20.21% and 20.18%). Moderate PCV and GCV were recorded for total fruit yield per plant (16.05% and 15.35%), average fruit weight (16.01% and 15.78%), reducing sugars (14.53% and 14.45%), number of primary branch per plant (13.68% and 13.23%), total phenol content (12.88% and 12.81%) and total sugars (12.14% and 12.07%). While, low PCV and GCV were recorded in fruit circumference (8.34% and 7.71%), total soluble solid (8.04% and 7.79%), days to 50% flowering (7.98% and 7.24%), fruit polar length (7.50% and 4.25%) and number of fruits per plant (6.73% and 6.05%). High estimates of heritability >75% were recorded for all the characters except days to first fruit harvest (59%).The heritability in broad sense ranged from 59 % in case of day to first fruit harvest to 99.90 %for ascorbic acid. High heritability (> 75 %) coupled with high genetic advance in per cent of mean (> 20) were recorded for ascorbic acid (99.90% and 41.50%), non-reducing sugar (99.00% and 71.21%), reducing sugars (99.00% and 29.61%), total phenol content (99.00% and 26.22%), total sugars (99.00% and 24.74 %), average fruit weight (97.00% and 32.03%), number of primary branch per plant (94.00% and 26.37%), total fruit yield per plant (92.00% and 30.26%) and plant height (90.00% and 22.16%)indicating that these traits were less influenced by environment. Thus, there exists ample genetic variability and as consequence scope of improvement in the available germplasm of brinjal.
Ensuring Patient Safety and Trust: The Critical Importance of Regulatory Compliance in Healthcare
Authors: Sharma Akash , Gamta Vriti , Luthra Gaurav
Published: July 2023

Regulatory compliance plays a pivotal role in the healthcare industry by ensuring patient safety, maintaining quality standards, and fostering trust between healthcare providers and patients. This research article aims to highlight the significance of regulatory compliance in healthcare, examining its impact on patient outcomes, organizational performance, and legal implications. Drawing upon existing literature and empirical evidence, this article underscores the need for robust compliance frameworks, effective monitoring systems, and continuous education to ensure adherence to regulatory requirements. By addressing key challenges and outlining best practices, this article provides valuable insights for healthcare organizations to enhance their compliance efforts and ultimately promote a safer and more reliable healthcare system.
A Child With Large Pulmonary and Liver Cysts
Authors: Shen Yuelin , Yu Wenbo , Wang Penggao
Published: July 2023

A previously healthy 7-year-old had 1 week of fevers, productive cough, and lethargy, which did not improve after 3 days of oral cefuroxime. He lived in a rural area and had close contact with dogs, cattle, and sheep. White blood cell count was 8000/μL, with 25.8% eosinophils; computed tomography showed a ruptured right upper lobe pulmonary cyst and 3 liver cysts. What is the diagnosis and what would you do next?
Revisiting the AA14 family of lytic polysaccharide monooxygenases and their catalytic activity
Authors: Tuveng Tina R. , Østby Heidi , Tamburrini Ketty C. , Bissaro Bastien , Hegnar Olav A. , Stepnov Anton A. , Várnai Anikó , Berrin Jean‐Guy , Eijsink Vincent G. H.
Published: July 2023

Lytic polysaccharide monooxygenases (LPMOs) belonging to the AA14 family are believed to contribute to the enzymatic degradation of lignocellulosic biomass by specifically acting on xylan in recalcitrant cellulose‐xylan complexes. Functional characterization of an AA14 LPMO from Trichoderma reesei, TrAA14A, and a re‐evaluation of the properties of the previously described AA14 from Pycnoporus coccineus, PcoAA14A, showed that these proteins have oxidase and peroxidase activities that are common for LPMOs. However, we were not able to detect activity on cellulose‐associated xylan or any other tested polysaccharide substrate, meaning that the substrate of these enzymes remains unknown. Next to raising questions regarding the true nature of AA14 LPMOs, the present data illustrate possible pitfalls in the functional characterization of these intriguing enzymes.
The G protein‐coupled receptor GPRC5C is a saccharide sensor with a novel ‘off’ response
Authors: Kawabata Yuko , Takai Shingo , Sanematsu Keisuke , Iwata Shusuke , Kawabata Fuminori , Kanematsu Takashi , Jimi Eijiro , Shigemura Noriatsu
Published: July 2023

GPRC5C is an orphan G protein‐coupled receptor (GPCR) that belongs to the class C GPCR family. Although GPRC5C is expressed in various organs, its function and ligand are still undetermined. We found that GPRC5C is expressed in mouse taste cells, enterocytes, and pancreatic α‐cells. In functional imaging assays, HEK293 cells heterologously expressing GPRC5C and the chimeric G protein α subunit Gα16‐gust44 showed robust intracellular Ca2+ increases in response to monosaccharides, disaccharides, and a sugar alcohol, but not an artificial sweetener or sweet‐tasting amino acid. Notably, Ca2+ increases occurred after washout, not during stimulation. Our findings suggest that GPRC5C has receptor properties which lead to novel ‘off’ responses to saccharide detachment and may work as an internal or external chemosensor specifically tuned to natural sugars.
Ultrasonication‐Assisted Seed Screening Enables Oriented and Efficient Low‐Dimensional Crystal‐Structural Thin‐Film Photovoltaics
Authors: Yan Bin , Feng Mingjie , Wang Cong , Li Zongbao , Lu Wenbo , Liu Shunchang , Hu Jin‐Song , Xue Ding‐Jiang
Published: July 2023

Ultrasonication‐assisted liquid exfoliation of layered materials is widely used to produce a large number of 2D nanosheets due to its simplicity, universality, and mass production. Here, the utility of ultrasonication is extended from liquid exfoliation to seed screening in the case of layered GeSe and GeS. It is found that the ultrasonic stripping force can also be used to selectively remove the lying seeds interacting with substrate through weak van der Waals (vdW) forces while retaining the standing seeds connected with substrate via tightly covalent bonds. The standing seeds then induce the growth of 2D crystal‐structural films with standing orientation. This thereby enables efficient carrier transport within covalently bonded layers, instead of poor transport between layers held together by vdW forces. The resulting standing‐oriented GeSe films exhibit a 21‐times increase in carrier mobility compared to lying‐oriented films. As a result, this study demonstrates the highest power conversion efficiencies of 6.1% and 10.5% under AM1.5G 1‐ and 0.01‐sun illumination reported for GeSe solar cells, respectively.
Tannic Acid‐Based Nanomaterials for Tolerogenic Immunotherapy of Rheumatoid Arthritis
Authors: Wu Yina , Park Jinwon , Jin Dongun , Lee Jaiwoo , Le Quoc‐Viet , Oh Yu‐Kyoung
Published: July 2023

Here, a tannic acid‐based nanomaterial is developed for treating rheumatoid arthritis by inducing antigen‐specific immune tolerance. The tolerogenic nanovaccine is designed for targeted delivery of dexamethasone and citrullinated peptide in a lipid‐coated nanoparticle consisting of tannic acid as core nanomaterial (CitDTN). The surface of CitDTN is modified with abatacept to yield AbaCitDTN. Abatacept modification enables the tolerogenic nanovaccine to target dendritic cells by interacting with the co‐stimulatory molecules, CD80 and CD86. This modification increases the lymph node accumulation of the tolerogenic nanovaccine upon subcutaneous administration. In addition, AbaCitDTN reprograms the properties of dendritic cells toward tolerogenic phenotypes and interrupts co‐stimulatory signals between dendritic cells and T cells, leading to suppressed T cell proliferation and interlukin‐2 secretion. Collagen‐induced arthritis DBA/1 model mice are subcutaneously administered with AbaCitDTN weekly for a total of four injections. This reduces inflammation in the synovial space and decreases autoimmunity against type II collagen and citrullinated peptide. In vivo administration of AbaCitDTN improves clinical symptoms and protects joints from destruction in this animal model. These findings suggest that tannic acid‐based nanomaterials could have potential to induce antigen‐specific immune tolerance for treating rheumatoid arthritis.
Repurposing Tamoxifen for Tumor Microenvironment Priming and Enhanced Tumor‐Targeted Drug Delivery
Authors: Biancacci Ilaria , De Santis Daniele , Rama Elena , Benderski Karina , Momoh Jeffrey , Pohlberger Robert , Moeckel Diana , Kaps Leonard , Rijcken Cristianne J. F. , Prakash Jai , Thewissen Marielle , Kiessling Fabian , Shi Yang , Peña Quim , Sofias Alexandros Marios , Consolino Lorena , Lammers Twan
Published: July 2023

The dense stromal matrix in fibrotic tumors hinders tumor‐targeted drug delivery. Tamoxifen (TMX), an estrogen receptor modulator that is clinically used for the treatment of breast cancer, is shown to reprogram the tumor microenvironment (TME) and to alleviate desmoplasia. It is investigated if TMX, administered in free and nano‐formulated form, can be repurposed as a TME remodeling agent to improve tumor accumulation of nano‐formulations in pancreatic ductal adenocarcinoma and triple‐negative breast cancer mouse models, evaluated using clinical‐stage Cy7‐labeled core‐crosslinked polymeric micelles (CCPM). Under control conditions, higher levels of Cy7‐CCPM are found in PANC‐1 tumors (16.7% ID g−1 at 48 h post i.v. injection) than in 4T1 tumors (11.0% ID g−1). In both models, free and nano‐formulated TMX failed to improve CCPM delivery. These findings are congruent with the results from histopathological immunofluorescence analysis of tumor tissue, which indicate that TMX treatment does not significantly change vascularization, perfusion, macrophage infiltration, collagen density, and collagen fiber thickness. Altogether, these results demonstrate that in PANC‐1 and 4T1 mouse models, TMX treatment does not contribute to beneficial TME priming and enhanced tumor‐targeted drug delivery.
Synthesis, Reaction Mechanism, DNA Cleavage and Antitumor Properties of Naphthoquinone‐Based Enediynes
Authors: Zheng Hongyu , Zeng Yun , Huang Xiaohua , Zhang Houjun , Pu Fangxu , Cheng Haonan , Li Zhuoyu , Ding Yun , Hu Aiguo
Published: July 2023

Under physiological conditions, natural enediynes antibiotics generate free radicals through a cycloaromatization reaction. The resulting highly reactive radicals can abstract hydrogen atoms on the phosphate backbone of DNA, leading to high cytotoxicity. On the other hand, anthraquinone‐fused compounds such as daunomycin and adriamycin can insert into DNA through planar aromatic ring structures, resulting in strong DNA damage. To this end, a series of naphthoquinone‐based enediynes were designed and synthesized by adjusting the type of terminal alkyne to modulate their water solubility and radical generation property. Theoretical calculations suggest that the naphthoquinone‐based enediyne generates radicals through a rearrangement (1,3‐proton transfer) followed by Myers‐Saito cyclization processes, with a much lower activation free energy barrier than Bergman cyclization (24.2 kcal/mol vs 39.8 kcal/mol). Differential scanning calorimetry and electron paramagnetic resonance results showed that naphthoquinone‐based enediynes undergo cycloaromatization at relatively low temperatures, resulting in the generation of highly reactive radical species. The enediynes with optimal water solubility displayed strong DNA cleavage ability at micromolar level and high cytotoxicity towards Hela cells, providing a half‐inhibitory concentration of 8.19 μM.
Copper‐Catalyzed Direct C−H Bond Oxidative Sulfonylation of β‐Alkyl Cyanoalkenes with Sodium Sulfinates
Authors: Jin Junyi , Zhou Kaiyang , Liu Xinxiang , Wang Can , Chen Yunfeng
Published: July 2023

A direct C−H bond oxidative sulfonylation of β‐alkyl cyanoalkenes with sodium sulfinates was reported. This transformation involves the use of a copper salt catalyst, along with a catalytic amount of I2 and DMSO as the oxidative system, which provides a straightforward and practical access to various cyanoallyllic sulfones.
Behavioral responses of mantled howler monkeys to neighbor long‐distance vocalizations
Authors: Maya Lastra Natalia , Rangel Negrín Ariadna , Dias Pedro A. D.
Published: July 2023

Objectives

Long‐distance vocalizations are used by primates in a variety of contexts and may have different functions. The long‐distance vocalizations of howler monkeys (Alouatta spp.) underlie the spatial regulation of neighboring groups and could be associated with the defense of food resources. Here, we test the hypothesis that the behavioral responses of mantled howler monkeys (A. palliata) to neighbor long‐distance vocalizations are influenced by the potential for range defensibility while accounting for location within the home range and food availability.

Methods

We studied two groups for 13 months and a total of 888 h at La Flor de Catemaco (Mexico). Group 1 had a 92‐ha home range and Group 2 had a 24‐ha home range. We recorded vocalizations (N = 178 calls) and movements (N = 74 movements) of focal groups following long‐distance vocalizations produced by their neighbors.

Results

Movement responses, but not vocal responses, were predicted by range defensibility, location, and food availability. As predicted, the group living in the smaller and more defendable range showed stronger movement responses than the group in the larger home range. These movement responses had a shorter latency and longer duration in more valuable spatial and temporal contexts (i.e., the core area and during periods of low food availability).

Conclusions

These results suggest that the tradeoff between the costs and benefits of range defense varies according to the interactions between home range size and both the spatial (core areas) and temporal (food availability) abundance of resources. Thus, the responses of mantled howler monkeys to neighbor long‐distance vocalizations could be related to home range defensibility.
Unravelling the Superiority of Nonbenzenoid Acepleiadylene as a Building Block for Organic Semiconducting Materials**
Authors: Fu Lin , Liu Pengcai , Xue Rui , Tang Xiao‐Yu , Cao Jiawen , Yao Ze‐Fan , Liu Yuchao , Yan Shouke , Wang Xiao‐Ye
Published: July 2023

Acepleiadylene (APD), a nonbenzenoid isomer of pyrene, exhibits a unique charge‐separated character with a large molecular dipole and a small optical gap. However, APD has never been explored in optoelectronic materials to take advantage of these appealing properties. Here, we employ APD as a building block in organic semiconducting materials for the first time, and unravel the superiority of nonbenzenoid APD in electronic applications. We have synthesized an APD derivative (APD‐IID) with APD as the terminal donor moieties and isoindigo (IID) as the acceptor core. Theoretical and experimental investigations reveal that APD‐IID has an obvious charge‐separated structure and enhanced intermolecular interactions as compared with its pyrene‐based isomers. As a result, APD‐IID displays significantly higher hole mobilities than those of the pyrene‐based counterparts. These results imply the advantages of employing APD in semiconducting materials and great potential of nonbenzenoid polycyclic arenes for optoelectronic applications.
COMPAS: Softwarelösung für komplexe Bauprojekte
Authors: Chen Li , Casas Gonzalo , Kasirer Chen , Van Mele Tom
Published: July 2023

In einem Bauprojekt arbeiten verschiedene Disziplinen wie Architektur, Ingenieurwesen, Fachplanung und ausführende Bauunternehmen zusammen. Für den Entwurf, die statische Berechnung und die Ausführungsplanung werden unterschiedliche Softwarelösungen eingesetzt. Anpassungen im Entwurf und der Planung müssen zeitaufwendig in jeder einzelnen Softwarelösung manuell eingearbeitet werden. Bei komplexen Geometrien und innovativen Bauweisen sind zusätzliche Analysen und Anpassungen erforderlich, was mit heutigen Softwarelösungen kaum realisierbar ist. Für einen effizienten Datentransfer zwischen verschiedenen Softwareumgebungen wurde COMPAS entwickelt, sodass Innovationen im Bauwesen gefördert werden. COMPAS ist eine Open‐Source‐Umgebung, welche unabhängig von kommerziellen Softwarelösungen verwendet werden kann. Es verfügt über eine Geometriedatenbank, flexible Datenstrukturen für unterschiedliche Disziplinen und Algorithmen für Berechnungen wie z. B. Tragwerksanalysen. Es gibt zahlreiche COMPAS‐Erweiterungen für spezifische Anwendungen wie Montageplanung, Holzbau, Roboterfertigung und additive Fertigung. Anfang 2023 wurde der Verein COMPAS gegründet, um die Weiterentwicklung und Ausbildung voranzutreiben.
Novel biomaterial advanced platelet‐rich fibrin plus block for multiple gingival recession
Authors: Mallappa Jayasheela , Patil Leena , Mani Adi Deepika , Gowda Triveni M.
Published: July 2023

Background

The study was aimed to assess and compare hard and soft tissue augmentation clinicoradiographically with and without advanced platelet‐rich fibrin + (A‐PRF+) block for the treatment of multiple gingival recession using vestibular incision subperiosteal tunnel access (VISTA).

Methods

A total of 24 patients, exhibiting multiple Miller's Class I or II recessions in the maxillary esthetic zone were included. Participants were divided into two groups, Group 1 was treated with VISTA & A‐PRF+ block whereas Group 2 was with VISTA technique alone. Clinical parameters probing depth, width of keratinized gingiva, gingival biotype, recession depth, and clinical attachment level were recorded at baseline and the end of 6 months. The radiographic cone beam computed tomography measurements of labial plate thickness were taken at baseline and 6 months postoperatively.

Results

From baseline to 6 months both the groups showed a clinical and statistical improvement in the parameters. However, a statistically significant difference between the treatment modalities was not observed. In the inter‐group comparison radiographically, labial plate thickness was statistically significant at the end of 6 months when compared to the baseline.

Conclusion

A‐PRF+ block along with the VISTA technique can be an alternative effective root coverage procedure for the management of multiple gingival recessions in the maxillary esthetic zone.

Key points

Why is this study new information?

To the best of our knowledge, this is the first study using advanced platelet‐rich fibrin plus block for the treatment of multiple gingival recession with a thin labial plate.

What are the keys to the successful management of these types of cases?

Minimally invasive vestibular incision subperiosteal tunnel access technique, and avoidance of second surgical site morbidity are important factors for treatment and for patient compliance.

What are the primary limitations of this study?

Short study duration, small sample size, and no histological correlation can be considered as limitations of the study.
Particle Size Distribution Model Fitting and Goodness‐of‐Fit Evaluation
Authors: Mao Haifang , Wang Chaoyang , Liu Jibo , Liu Kejia , Zheng Wei , Tang Ting , Jin Miaomiao
Published: July 2023

Six mathematical models were selected for the fitting and regression of the particle size distribution (PSD) of (α,Z)‐2‐amino‐α‐(methoxyimino)‐4‐thiazole‐ethanethioic acid S‐2‐benzothiazolyl ester (MAEM). The goodness‐of‐fit was evaluated by comparing the evaluation indexes such as R2, Akaike's information criterion (AIC), and root mean square error (RMSE). The top three selected models were further applied and compared for the PSD of MAEM produced under two different stirring speeds with distinct differences in regression coefficients. In addition, FBRM monitored the particle number trends on a lab scale under these stirring speeds. Finally, a feasible reaction mechanism was presented in which the dissolution of reactants was the rate‐controlling step which could explain the significant influence on stirring speed.
Mn(II) Polypyridyl Complexes: Precursors to High Valent Mn(V)=O Species and Inhibitors of Cancer Cell Proliferation
Authors: Arora Pragya , Gupta Sikha , Kumari Vechalapu Sai , Kumar Rakesh , Awasthi Ayushi , Senthil Sathyapriya , Khanna Shweta , Allimuthu Dharmaraja , Draksharapu Apparao
Published: July 2023

The reaction of [(L)MnII]2+ (L = neutral polypyridine ligand framework) in the presence of mCPBA (mCPBA = m‐Chloroperoxybenzoic acid) generates a putative MnV=O species at RT. The proposed MnV=O species is capable of performing the aromatic hydroxylation of Cl‐benzoic acid derived from mCPBA to give [(L)MnIII(m‐Cl‐salicylate)]+, which in the presence of excess mCPBA generates a metastable [(L)MnV(O)(m‐Cl‐salicylate)]+, characterized by UV/Vis absorption, EPR, resonance Raman spectroscopy, and ESI‐MS studies. The current study highlights the fact that [(L)MnIII(m‐Cl‐salicylate)]+ formation may not be a dead end for catalysis. Further, a plausible mechanism has been proposed for the formation of [(L)MnV(O)‐m‐Cl‐salicylate)]+ from [(L)MnIII(m‐Cl‐salicylate)]+. The characterized transient [(L)MnV(O)‐m‐Cl‐salicylate)]+ reported in the current work exhibits high reactivity for oxygen atom transfer reactions, supported by the electrophilic character depicted from Hammett studies using a series of para‐substituted thioanisoles. The unprecedented study starting from a non‐heme neutral polypyridine ligand framework paves a path for mimicking the natural active site of photosystem II under ambient conditions. Finally, evaluating the intracellular effect of Mn(II) complexes revealed an enhanced intracellular ROS and mitochondrial dysfunction to prevent the proliferation of hepatocellular carcinoma and breast cancer cells.
PROTOCOL: Do hospital leadership styles predict patient safety indicators? A systematic review
Authors: Buttigieg Sandra C. , Riva Nicoletta , Tomaselli Gianpaolo , Said Emanuel , Grech Elaine , Cassar Vincent
Published: July 2023

This is the protocol for a Campbell systematic review. The objectives are as follows: The main aim of this systematic review is to identify whether hospital leadership styles predict patient safety as measured through several indicators over time. The second aim is to assess the extent to which the prediction of hospital leadership styles on patient safety indicators varies as a function of the leader's hierarchy level in the organization.
Studying Molecular Rearrangement of P1 Dye at a Passivating Alumina Surface Using Vibrational Sum‐Frequency Generation Spectroscopy: Effect of Atomic‐Level Roughness
Authors: De Ratnadip , Bera Anupam , Schmidt Heiner , Neumann Christof , Paa Wolfgang , Gawlik Annett , Turchanin Andrey , Dietzek‐Ivanšić Benjamin
Published: July 2023

The effect of roughness and thickness of alumina layers, mimicking the passivation layer commonly used in dye‐sensitized photoelectrodes, on the molecular adsorption of P1 dye, 4‐(bi(4‐(2,2‐dicyano‐vinyl)‐thiophene‐2‐yl]‐phenyl]‐aminobenzoic acid) has been studied using surface‐sensitive vibrational sum frequency generation(VSFG) spectroscopy. The VSFG spectra reveal the formation of poorly ordered dye layers on relatively rough surfaces where XPS measures a higher dye loading. Furthermore, these poorly ordered dye molecules are responsible for the generation of trapped electronic states as probed by successive photoluminescence (PL) measurements. Surface sensitive VSFG spectroscopy in combination with XPS and PL measurements provide complementary spectral information on ordering of the adsorbed dyes, their density on the surface and electronic states of the adsorbed monolayer which are prerequisite for improving our understanding of molecularly functionalized photoelectrodes and their further development.
Are dental visiting patterns and oral pain associated with dental disease among Norwegian adults? A cross‐sectional study based on the Tromsø study
Authors: Nermo Hege , Hadler‐Olsen Elin
Published: July 2023

Objectives

The present study aims to describe the dental visiting patterns in a Norwegian adult population and their associations with sociodemographic and oral health variables, including oral pain. We further explore if the utilization of dental health services and oral pain predicts caries and periodontitis, the most common oral diseases.

Materials and Methods

We use data from the seventh wave of the Tromsø study performed in 2015–2016. In this cross‐sectional survey, all residents 40 years or older in Tromsø municipality in Norway were invited, of whom 21,083 (65%) participated. All participants answered questionnaires assessing sociodemographic characteristics, use of health services, and self‐reported health measures, including pain. Almost 4000 participants underwent a dental examination with registration of caries and periodontitis. Associations of dental visiting patterns and utilization of dental services the past 12 months with sociodemographic‐, self‐reported‐, and clinical oral health measures were analyzed by cross‐tabulation and Pearson's χ2 tests, as well as with logistic regression analyses with caries and periodontitis as outcomes.

Results

A regular, annual dental visiting pattern was the most common, but among respondents with severe dental anxiety and poor dental health, visiting for acute problems only or never (symptomatic visiting) was the most common. Intervals of more than 24 months between visits and a symptomatic visiting pattern were associated with caries, whereas shorter than 12‐month intervals and a symptomatic visiting pattern were associated with periodontitis. Many characteristics were shared among respondents with the lowest and the highest utilization of dental services, including oral pain, a difficult financial situation and poorer self‐reported and clinical dental health.

Conclusions

Regular dental visits at 12–24 month intervals were associated with beneficial oral health parameters, compared with more frequent, rarer, and symptomatic dental visiting patterns. Oral pain was an unreliable predictor of caries and periodontitis.
Enhancing the wind farm‐based power system stability with coordinated tuned supplementary controller
Authors: Bhukya Jawaharlal
Published: July 2023

The effects of the wind farm on the low‐frequency oscillations of interconnected power systems have become a significant problem with extensive apprehension. These low‐frequency oscillations are undesirable, malfunctioning and resulting in system instability. This paper studies the influence of various factors on stability, with varying wind penetration, a different combination of controllers, wind farm (WF) integration and replacement of synchronous generators. To enhance the stability, it is integrated and analyzed significance of the controller by considering the power oscillation damper for WF, power system stabilizer for synchronous generators and supplementary controller of flexible AC transmission system devices for the system. The rotor speed deviation is considered an objective function with various constraints for particle swarm optimization to provide the controller's optimized value and combination. The small‐signal and transient stability problems were examined using eigenvalue analysis and time‐domain simulation. The state‐space formulation is derived for eigenvalue analysis for small signal stability assessment with system variables. The nonlinear dynamic simulation results for transient stability analysis are obtained using a three‐phase fault. From stability analysis, coordinated controllers intensify the capability of SGs and WF under extreme disturbances. The effectiveness and robustness of the proposed approaches have been verified using the IEEE‐9 bus test system. All the analysis and simulations are performed using real time digital simulation (RTDS) with interfacing between MATLAB/SIMULINK‐2018a software and RT‐LAB (an OP5600 RT‐LAB).
Competition between pink muhly grass and native plant species: Is it really a harmful invasive species?
Authors: Byun Chaeho
Published: July 2023

Pink muhly grass (Muhlenbergia capillaris Trin.) is an exotic species in South Korea and is popular worldwide as an ornamental grass for landscaping purposes. The Ministry of Environment in South Korea has categorized this species as an “Ecosystem Hazard Class 2” plant, requiring long‐term monitoring to assess its ecological impacts on native species and communities. In this study, a 2‐year greenhouse experiment was conducted using M. capillaris and 17 native plant species (6 annuals, 8 nonwoody perennials, and 3 woody perennials) to test the hypothesis that if M. capillaris is an invasive species, it will negatively affect the establishment and growth of native plants in competitive pairings compared with controls (native species grown in monoculture). Results showed that the mean canopy cover of native plants in competition with M. capillaris was not significantly different from monocultures of the corresponding native species. There were also no significant differences in mean aboveground biomass production between native species growing with M. capillaris compared to corresponding native monocultures. Results indicate that M. capillaris did not significantly affect the establishment and growth of the 17 native species investigated. The minimal impacts suggest that M. capillaris may not be a harmful invasive species, but further monitoring of its spread will be required to test these findings under natural conditions.
Chemoenzymatic Synthesis of Enantiopure Amino Alcohols from Simple Methyl Ketones
Authors: Neuburger Jan Eric , Gazizova Alina , Tiedemann Sven , von Langermann Jan
Published: July 2023

This study highlights the straight‐forward synthesis of substituted 1,2‐amino alcohols from simple and readily available aromatic methyl ketones. Starting from acetophenone derivatives, the straight‐forward synthesis strategy involved an initial bromination of the alpha‐positioned methyl group in the first step, followed by a simple hydrolysis to the hydroxyketone (2‐hydroxyacetophenone). The hydroxylated intermediate was subsequently converted from Silicibacter pomeroyi to the final 1,2‐amino alcohol by using the transaminase. The transaminase‐catalyzed reaction proceeded with yields up to 62 % and always excellent enantiomeric excess of >99 %. Interestingly, the keto‐enol‐tautomerism of the hydroxyl ketone yields an unexpected amino alcohol isomer.
Statistical optimization of ultrasound‐assisted biodiesel production from Moringa oleifera oil – waste cooking oil mixture using modified conch shell catalyst
Authors: Niju Subramaniapillai , Aishwarya Kesav , Balajii Muthusamy , Asaithambi Perumal
Published: July 2023

Biodiesel is a potential alternative fuel that offers several environmental benefits and can be used in conventional engines. However, high feedstock cost poses a challenge for its commercial viability. This study focuses on producing biodiesel using waste cooking oil (WCO) and Moringa oleifera oil (MOO) as feedstock, with a specific emphasis on the use of modified conch shell as solid catalyst under ultrasonic conditions. Different mixtures of WCO and MOO were evaluated for their suitability in a two‐stage esterification transesterification process, and the acid value of the WCO‐MOO blend was reduced through an ultrasound‐assisted esterification process. Additionally, a calcium oxide‐based catalyst was developed from conch shells (CS) through calcination for 3 h at 900°C and further modified using water and methanol. The characterization studies confirm the successful development and modification of the CS catalyst and also demonstrates excellent catalytic activity. The ultrasound assisted transesterification process parameters were optimized using response surface methodology (RSM) based Box–Behnken design (BBD). By employing a catalyst loading of 5.8 wt%, methanol to esterified oil volumetric ratio of 0.37:1, and an ultrasonication time of 57 min, a maximum predicted methyl ester conversion of 94.7% was achieved. Therefore, this work provides valuable insights into the use of modified conch shell catalyst for biodiesel production from WCO and MOO mixtures thereby contributing to the advancement of cost‐effective and environmentally friendly biodiesel production methods.
Affordable Care Act Medicaid expansions and maternal morbidity
Authors: Chatterji Pinka , Glenn Hanna , Markowitz Sara , Montez Jennifer Karas
Published: July 2023

In this paper, we test whether the Affordable Care Act Medicaid expansions are associated with maternal morbidity. The ACA expansions may have affected maternal morbidity by increasing pre‐conception access to health care, and by improving the quality of delivery care, through enhancing hospitals' financial positions. We use difference‐in‐difference models in conjunction with event studies. Data come from individual‐level birth certificates and state‐level hospital discharge data. The results show little evidence that the expansions are associated with overall maternal morbidity or indicators of specific adverse events including eclampsia, ruptured uterus, and unplanned hysterectomy. The results are consistent with prior research showing that the ACA Medicaid expansions are not statistically associated with pre‐pregnancy health or maternal health during pregnancy. Our results add to this story and find little evidence of improvements in maternal health upon delivery.
The urgent need for a policy on epidemiological data on cardiovascular diseases in Bangladesh
Authors: Proma Amrin Yeasin , Das Proma Rani , Akter Sayma , Dewan Syed Masudur Rahman , Islam Mohammad Safiqul
Published: July 2023

Background

Disease prevention and healthcare policy choices cannot be made without epidemiology data. Since it is a growing country with rapidly increasing illness rates, this information is in great demand in Bangladesh. This is because there is a shortage of reliable and sufficient data, leading to inadequate preventive and treatment methods.

Discussion

Poor health concerns and economic conditions mean that not all families can afford to provide the nutrition their members need, leading to an increase in the prevalence of many diseases. The outcome is an ever‐increasing threat of cardiovascular disease (CVD) issues, the leading cause of death in Bangladesh, even though the underlying causes remain unknown. There is a strong demand for accurate information on CVD patients in Bangladesh, however, there is no effective framework for managing epidemiological data. This prevents an in‐depth analysis of the nation's socioeconomic status, dietary practices, and way of life, as well as the implementation of sound healthcare policy.

Conclusion

In this article, we present arguments on this important issue using the healthcare systems of the developed world and Bangladesh as examples.