bluuebunny/crossref_metadata_2025 huggingface dataset:
Using hydrodynamic and hydraulic modelling to study microbiological water quality issues at a backwater area of the Danube to support decision-making
Authors: Derx Julia , Komma Jürgen , Reiner Philipp , Vierheilig Julia , Savio Domenico , Sommer Regina , Kirschner Alexander K. T. , Frick Christina , Linke Rita , Farnleitner Andreas H. , Blaschke Alfred Paul
Published: September 2021

The alluvial backwater areas of the Danube are valuable ecological habitats containing important drinking water resources. Due to the river regulation and the construction of power plants, the river water levels and natural dynamics of the backwater areas continuously decline, threatening their typical characteristics. The aim of this study was to evaluate how an increased connectivity of the backwater branch located in a nature-protected riverine floodplain (enabled by diverting river water into the backwater system via a weir) affects the microbiological quality of groundwater resources. The defined quality criterion was that the diversion measures must not lead to an increased detection frequency of faecal indicators in groundwater. The microbiological water quality of the Danube, its backwater branch and the groundwater was analysed from 2010 to 2013. E. coli was selected as bacterial indicator for recent faecal pollution. C. perfringens (spores) was analysed as indicator for persistent faecal pollution and potentially occurring pathogenic protozoa. We simulated the microbial transport from the Danube and the backwater river into groundwater using a 3‑D unsaturated-saturated groundwater model coupled with 2‑D hydrodynamic flow simulations. Scenarios for no diversion measures were compared with scenarios for an additional discharge of 3, 20 and 80 m3/s from the Danube River into the backwater branch. While the additional discharge of 20 and 80 m3/s of Danube water into the floodplain strongly improved the ecological status according to ecological habitat models, the hydraulic transport simulations showed that this would result in a deterioration of the microbiological quality of groundwater resources. The presented approach shows how hydraulic transport modelling and microbiological analyses can be combined to support decision-making.
Characteristic phenotype of Chinese patients with adult-onset diabetes who are autoantibody positive by 3-Screen ICA™ ELISA
Authors: Wang Zhida , Guo Liang , Chen Shu , Guan Jun , Powell Michael , Furmaniak Jadwiga , Rees Smith Bernard , Chen Liming
Published: September 2021

Aims

To assess the prevalence of diabetes-associated autoantibodies in Chinese patients recently diagnosed with adult-onset diabetes and to evaluate the potential role of the autoantibody markers for characterization of disease phenotype in the patient population.

Methods

The study included 1273 recent-onset adult patients with phenotypic type 2 diabetes mellitus (T2DM). Serum samples were tested using the 3-Screen ICA™ ELISA (3-Screen) designed for combined measurement of GADAb and/or IA-2Ab and/or ZnT8Ab. 3-Screen positive samples were then tested for individual diabetes-associated and other organ-specific autoantibodies. Clinical characteristics of patients positive and negative in 3-Screen were analysed.

Results

Forty-four (3.5%) of the T2DM patients were positive in 3-Screen, and 38 (86%) of these were also positive for at least one of GADAb, IA-2Ab and ZnT8Ab in assays for the individual autoantibodies. 3-Screen positive patients had lower BMI, higher HbA1c, lower fasting insulin levels and lower fasting C-peptide levels compared to 3-Screen negative patients. Analysis using a homeostatic model assessment (HOMA2) indicated that HOMA2-β-cell function was significantly lower for the forty-four 3-Screen positive patients compared to 3-Screen negative patients.

Twenty (45%) 3-Screen positive patients were also positive for at least one thyroid autoantibody.

Conclusions

The 3-Screen ELISA has been used successfully for the first time in China to detect diabetes autoantibodies in patients with phenotypic T2DM. 3-Screen positive patients presented with poorer β cell function.
Coalition-proof stable networks
Authors: Luo Chenghong , Mauleon Ana , Vannetelbosch Vincent
Published: September 2021

We propose the notion of coalition-proof stability for predicting the networks that could emerge when group deviations are allowed. A network is coalition-proof stable if there exists no coalition which has a credible group deviation. A coalition is said to have a credible group deviation if there is a profitable group deviation to some network and there is no subcoalition of the deviating players which has a subsequent credible group deviation. Coalition-proof stability is a coarsening of strong stability. We emphasize the importance of coalition-proof stability by considering four models where a strongly stable network fails to exist while a coalition-proof stable network does exist. We provide an easy to verify condition for the existence of a coalition-proof stable network while a strongly stable network may not exist. There is no relationship between the set of coalition-proof stable networks and the set of networks induced by a coalition-proof Nash equilibrium of Myerson’s linking game.
The learning experiences of dyslexic medical students during the COVID-19 pandemic: a phenomenological study
Authors: Shaw Sebastian C. K. , Hennessy Laura R. , Anderson John L.
Published: September 2021

Dyslexia is a Specific Learning Difficulty that impacts on reading and writing abilities. During the COVID-19 pandemic, medical schools have been forced to undertake distance learning and assessment. The wider literature suggested that e-learning might pose additional challenges for dyslexic students. Here we explore their overall experiences of learning/studying during this time in a phenomenological study. Five medical students were interviewed in depth and the audio-recordings were transcribed verbatim. Transcripts then underwent an interpretive phenomenological analysis. Our results highlighted a largely positive experience, with an improved culture of togetherness, freedom and sense of control. They also revealed issues with a lack of clinical exposure, potential negative impacts on ranking positions for those with dyslexia, and possible cheating in exams. There are some surprising results—in particular the positive responses to how remote learning was delivered. These seemed to put our participants more on a par with their non-dyslexic colleagues—except in some examinations. It is our hope that medical educators may resist a return to ‘the way things have always been done’ when the pandemic has resolved, and by doing so, continue to foster this new, positive culture and paradigm shift.
Modes and Dimensions of Being
Authors: Alvargonzález David
Published: September 2021

In this paper, I put forward a theory about the modes and dimensions of being. In the first section, I define existence through coexistence, understood as the codetermination of certain things and processes via other things and processes. In the second section, I differentiate between modes and dimensions of being. In the third section, I argue that the modes of existing are the different ways in which coexistence and codetermination take place and discuss two types of modes ("fundamental" and "categorial"), to subsequently present a classification thereof. In the fourth section, I posit a theory about the dimensions of any existing thing or process, arguing for the existence of two types of dimensions: configurational and processual.
Distinguishing pure histopathological growth patterns of colorectal liver metastases on CT using deep learning and radiomics: a pilot study
Authors: Starmans Martijn P. A. , Buisman Florian E. , Renckens Michel , Willemssen François E. J. A. , van der Voort Sebastian R. , Groot Koerkamp Bas , Grünhagen Dirk J. , Niessen Wiro J. , Vermeulen Peter B. , Verhoef Cornelis , Visser Jacob J. , Klein Stefan
Published: September 2021

Histopathological growth patterns (HGPs) are independent prognosticators for colorectal liver metastases (CRLM). Currently, HGPs are determined postoperatively. In this study, we evaluated radiomics for preoperative prediction of HGPs on computed tomography (CT), and its robustness to segmentation and acquisition variations. Patients with pure HGPs [i.e. 100% desmoplastic (dHGP) or 100% replacement (rHGP)] and a CT-scan who were surgically treated at the Erasmus MC between 2003–2015 were included retrospectively. Each lesion was segmented by three clinicians and a convolutional neural network (CNN). A prediction model was created using 564 radiomics features and a combination of machine learning approaches by training on the clinician’s and testing on the unseen CNN segmentations. The intra-class correlation coefficient (ICC) was used to select features robust to segmentation variations; ComBat was used to harmonize for acquisition variations. Evaluation was performed through a 100 × random-split cross-validation. The study included 93 CRLM in 76 patients (48% dHGP; 52% rHGP). Despite substantial differences between the segmentations of the three clinicians and the CNN, the radiomics model had a mean area under the curve of 0.69. ICC-based feature selection or ComBat yielded no improvement. Concluding, the combination of a CNN for segmentation and radiomics for classification has potential for automatically distinguishing dHGPs from rHGP, and is robust to segmentation and acquisition variations. Pending further optimization, including extension to mixed HGPs, our model may serve as a preoperative addition to postoperative HGP assessment, enabling further exploitation of HGPs as a biomarker.
Negative Posttraumatic Cognitions Color the Pathway from Event Centrality to Posttraumatic Stress Disorder Symptoms
Authors: Johanßen Helen , Schoofs Nikola , Kliegl Reinhold , Bermpohl Felix , Ülsmann Dominik , Schulte-Herbrüggen Olaf , Priebe Kathlen
Published: September 2021

Background

The centrality of an event indicates the extent to which it becomes a core part of identity and life story. Event centrality (EC) has been shown to have a strong relationship with PTSD symptoms, which seems to be indirectly influenced by negative posttraumatic cognitions (PTC). However, research on this potential mediation and its causal links particularly with clinical samples is limited and essential to derive treatment implications.

Methods

Pre- and posttreatment data of 103 day-unit patients with PTSD was examined using mediation analyses and structural equation modeling.

Results

Negative PTC mediated the relationship between EC and PTSD symptoms, partially pre- and completely posttreatment. Within extended longitudinal analyses causal directions of the mediation pathways were not adequately interpretable due to unexpected suppression effects.

Conclusions

The results suggest that EC may only have an indirect effect on PTSD symptoms through negative PTC. Thus, decreasing negative PTC which are connected to centralized events might be a key element for PTSD treatment. Thereby, transforming the cognitions’ valence to more positive and constructive forms could be crucial rather than mere decentralization. Although suppression effects limited causal inferences, they do not contradict the mediation and further indicate potential interactional terms and a transformation of EC.
Know More, Spend More? The Impact of Financial Literacy on Household Consumption
Authors: Dinkova Milena , Kalwij Adriaan , Alessie Rob
Published: September 2021

This paper examines the relationship between household consumption and financial literacy. The economic framework is a simple life-cycle model of consumption in which financial literacy affects the rate of return on assets. The theoretical predictions are that, for plausible values of the intertemporal elasticity of substitution, financial literacy is positively related to both the level of consumption and consumption growth. We empirically test these theoretical predictions with Dutch data from the LISS household panel. Our results provide evidence in favour of a positive association between non-durable consumption, and in particular food consumption, and financial literacy. No evidence is, however, found in favour of an association between consumption growth and financial literacy.
Variation in herpetofauna detection probabilities: implications for study design
Authors: Baumgardt Jeremy A. , Morrison Michael L. , Brennan Leonard A. , Thornley Madeleine , Campbell Tyler A.
Published: September 2021

Population monitoring is fundamental for informing management decisions aimed at reducing the rapid rate of global biodiversity decline. Herpetofauna are experiencing declines worldwide and include species that are challenging to monitor. Raw counts and associated metrics such as richness indices are common for monitoring populations of herpetofauna; however, these methods are susceptible to bias as they fail to account for varying detection probabilities. Our goal was to develop a program for efficiently monitoring herpetofauna in southern Texas. Our objectives were to (1) estimate detection probabilities in an occupancy modeling framework using trap arrays for a diverse group of herpetofauna and (2) to evaluate the relative effectiveness of funnel traps, pitfall traps, and cover boards. We collected data with 36 arrays at 2 study sites in 2015 and 2016, for 2105 array-days resulting in 4839 detections of 51 species. We modeled occupancy for 21 species and found support for the hypothesis that detection probability varied over our sampling duration for 10 species and with rainfall for 10 species. For herpetofauna in our study, we found 14 and 12 species were most efficiently captured with funnel traps and pitfall traps, respectively, and no species were most efficiently captured with cover boards. Our results show that using methods that do not account for variations in detection probability are highly subject to bias unless the likelihood of false absences is minimized with exceptionally long capture durations. For monitoring herpetofauna in southern Texas, we recommend using arrays with funnel and pitfall traps and an analytical method such as occupancy modeling that accounts for variation in detection.
The Grounds and the Components of Concepts
Authors: Claas Jan
Published: September 2021

In this paper I investigate the idea that in conceptual analysis we are in a substantial way concerned with revealing metaphysical grounds. I argue that a recent proposal fails, according to which we aim to reveal what complex concepts are grounded in. The notion ofcomposition, rather than that ofgrounding, is the best way to understand the intuitive hierarchy of concepts. In an analysis we reveal thecomponentsorpartsof complex concepts and their structure. Finally, I propose an alternative role for grounding in our accounts of analysis: in analyses we reveal truths about the composition of concepts that serve as grounds for truths about theirfunctions, which are what we want to understand.
Vacuity in synthesis
Authors: Bloem Roderick , Chockler Hana , Ebrahimi Masoud , Strichman Ofer
Published: September 2021

In reactive synthesis, one begins with a temporal specification $$\varphi $$
φ
, and automatically synthesizes a system $$M$$
M
such that $$M\models \varphi $$

M
⊧
φ

. As many systems can satisfy a given specification, it is natural to seek ways to force the synthesis tool to synthesize systems that are of a higher quality, in some well-defined sense. In this article we focus on a well-known measure of the way in which a system satisfies its specification, namely vacuity. Our conjecture is that if the synthesized system M satisfies $$\varphi $$
φ
non-vacuously, then M is likely to be closer to the user’s intent, because it satisfies $$\varphi $$
φ
in a more “meaningful” way. Narrowing the gap between the formal specification and the designer’s intent in this way, automatically, is the topic of this article. Specifically, we propose a bounded synthesis method for achieving this goal. The notion of vacuity as defined in the context of model checking, however, is not necessarily refined enough for the purpose of synthesis. Hence, even when the synthesized system is technically non-vacuous, there are yet more interesting (equivalently, less vacuous) systems, and we would like to be able to synthesize them. To that end, we cope with the problem of synthesizing a system that is as non-vacuous as possible, given that the set of interesting behaviours with respect to a given specification induce a partial order on transition systems. On the theoretical side we show examples of specifications for which there is a single maximal element in the partial order (i.e., the most interesting system), a set of equivalent maximal elements, or a number of incomparable maximal elements. We also show examples of specifications that induce infinite chains of increasingly interesting systems. These results have implications on how non-vacuous the synthesized system can be. We implemented the new procedure in our synthesis tool PARTY. For this purpose we added to it the capability to synthesize a system based on a property which is a conjunction of universal and existential LTL formulas.
Influence of drought and salt stress on the growth of young Populus nigra ‘Italica’ plants and associated mycorrhizal fungi and non-mycorrhizal fungal endophytes
Authors: Kulczyk-Skrzeszewska Magdalena , Kieliszewska-Rokicka Barbara
Published: September 2021

Populus nigra ‘Italica’ (Lombardy poplar) is a breeding cultivar of black poplar, widely used as a street tree or windbreak, often exposed to salinity and limited water availability. Populus roots can develop dual mycorrhizal associations with ectomycorrhizal (ECM) and arbuscular mycorrhizal (AM) fungi, and with non-mycorrhizal fungal endophytes (FE). The symbiotic fungi may alleviate the effects of adverse environmental conditions. We investigated the performance (growth and symbiotic associations) of one-year-old Populus nigra ‘Italica’ grown from woody cuttings in soil from natural poplar habitat and subjected to water scarcity and soil salinity (50 mM NaCl, 150 mM NaCl, 250 mM NaCl). With increasing soil salinity, a decrease in the growth parameters of the aboveground parts of the poplar plantlets and their fine roots were found; however, the roots were more resistant to the stress factors analyzed than the shoots. ECMF, AMF, and non-mycorrhizal FE were all tolerant to increased salt levels in the soil, and the ECM abundance was significantly higher under conditions of mild salinity (50 mM NaCl, 150 mM NaCl) compared to the control plants and those treated with 250 mM NaCl. Our results indicated that enhanced soil salinity increased the content of sodium and chlorine in leaves, but did not affect significantly the concentrations potassium, magnesium, calcium, phosphorus, or nitrogen. Significant accumulation of proline in leaves suggest salt stress of P. nigra ‘Italica’ treated with 250 mM NaCl and contribution of proline to the plant defense reactions.
High-dimensional structure learning of sparse vector autoregressive models using fractional marginal pseudo-likelihood
Authors: Suotsalo Kimmo , Xu Yingying , Corander Jukka , Pensar Johan
Published: September 2021

Learning vector autoregressive models from multivariate time series is conventionally approached through least squares or maximum likelihood estimation. These methods typically assume a fully connected model which provides no direct insight to the model structure and may lead to highly noisy estimates of the parameters. Because of these limitations, there has been an increasing interest towards methods that produce sparse estimates through penalized regression. However, such methods are computationally intensive and may become prohibitively time-consuming when the number of variables in the model increases. In this paper we adopt an approximate Bayesian approach to the learning problem by combining fractional marginal likelihood and pseudo-likelihood. We propose a novel method, PLVAR, that is both faster and produces more accurate estimates than the state-of-the-art methods based on penalized regression. We prove the consistency of the PLVAR estimator and demonstrate the attractive performance of the method on both simulated and real-world data.
In defence of explanatory realism
Authors: Roski Stefan
Published: September 2021

Explanatory realism is the view that explanations work by providing information about relations of productive determination such as causation or grounding. The view has gained considerable popularity in the last decades, especially in the context of metaphysical debates about non-causal explanation. What makes the view particularly attractive is that it fits nicely with the idea that not all explanations are causal whilst avoiding an implausible pluralism about explanation. Another attractive feature of the view is that it allows explanation to be a partially epistemic, context-dependent phenomenon. In spite of its attractiveness, explanatory realism has recently been subject to criticism. In particular, Taylor (Philos Stud 175(1):197–219, 2018). has presented four types of explanation that the view allegedly cannot account for. This paper defends explanatory realism against Taylor’s challenges. We will show that Taylor’s counterexamples are either explanations that turn out to provide information about entities standing in productive determination relations or that they are not genuine explanations in the first place.
Contributions to Operational Psychology: Psychological Training Model in the Context of Stress Management for Specialized German Military Police Personnel and Specialized Police Personnel
Authors: Steingräber Anne-Marie , Tübben Nick , Brinkmann Niels , Finkeldey Felix , Migutin Slava , Bürger Anna , Laubstein Alice , Abel Bernd , von Lüdinghausen Nicola , Herzberg Philipp Yorck , Lorei Clemens , Hanssen Niels , Gorzka Robert-Jacek
Published: September 2021

The service of specialized and special forces of the Federal Armed Forces and police is characterized by complex situations. Such personnel often face numerous difficulties and extreme danger and experience periods of high stress when fulfilling their tasks. In the context of social and technological changes, it is necessary to explore the individual components of stress management in further detail, i.e., stress prevention, stress control, and stress coping mechanisms, and furthermore to consider these elements in the fields of training and service. For this purpose, a stress management model was created based on participant observations, expert ratings, and problem-centered interviews with specialized members of military police and special police forces. The results of the validation can be interpreted as suggesting that effective stress management requires a diverse range of techniques and methods, including the use of digital means such as e-learning, digital reality, and eye tracking, in order to be able to address new demands appropriately.
Safety and efficacy of peptide receptor radionuclide therapy with 177Lu-DOTA0-Tyr3-octreotate in combination with amino acid solution infusion in Japanese patients with somatostatin receptor-positive, progressive neuroendocrine tumors
Authors: Kobayashi Noritoshi , Takano Shoko , Ito Kenichi , Sugiura Madoka , Ogawa Matsuyoshi , Takeda Yuma , Okubo Naoki , Suzuki Akihiro , Tokuhisa Motohiko , Kaneta Tomohiro , Utsunomiya Daisuke , Hata Masaharu , Inoue Tomio , Hosono Makoto , Kinuya Seigo , Ichikawa Yasushi
Published: September 2021

Purpose

Peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTA0-Tyr3-octreotate (177Lu-DOTATATE) is one of the most reliable treatments for unresectable, progressive neuroendocrine tumors (NETs) with somatostatin receptor expression. We have, for the first time, reported the results of the tolerability, safety, pharmacokinetics, dosimetry, and efficacy of this treatment for Japanese patients with NET.

Methods

Patients with unresectable, somatostatin receptor scintigraphy (SRS)-positive NETs were enrolled in this phase I clinical trial. They were treated with 29.6 GBq of 177Lu-DOTATATE (four doses of 7.4 GBq) combined with amino acid solution infusion plus octreotide long-acting release (LAR) 30 mg. The primary objective of this study was to evaluate the tolerability, safety, pharmacokinetics, and dosimetry of a single administration of this treatment in patients with SRS-positive NETs.

Results

Six Japanese patients (three men and three women; mean age 61.5 years; range 50–70 years) with SRS-positive unresectable NETs were recruited. 177Lu-DOTATATE was eliminated from the blood in a two-phase manner. Cumulative urinary excretion of radioactivity was 60.1% (range 49.0%–69.8%) within the initial 6 h. The cumulative renal absorbed dose for 29.6 GBq of 177Lu-DOTATATE was 16.8 Gy (range 12.0–21.2 Gy), and the biological effective dose was 17.0 Gy (range 12.2–21.5 Gy). Administration of 177Lu-DOTATATE was well tolerated, with no dose-limiting toxicities. Grade 3 lymphopenia occurred in two (33.3%) cases, but there were no other severe toxicities. Four patients achieved partial response (objective response rate, 66.7%), one patient had stable disease, and one patient had progressive disease.

Conclusion

PRRT with 177Lu-DOTATATE was well-tolerated and showed good outcomes in Japanese patients with unresectable NETs. Peptide receptor radionuclide therapy, 177Lu-DOTA0-Tyr3-octreotate .
Kinderschmerztherapie – ein Stiefkind?
Authors: Sator Sabine
Published: September 2021

Diagnosefindung und eine spezifische Schmerztherapie bei Kindern mit chronischen Schmerzen ist oft langwierig und leider insuffizient. Viele Medikamente, die am internationalen Markt zur Verfügung stehen, sind off label. Nur wenige Studien belegen die Wirksamkeit und Nebenwirkung in der Kinderschmerztherapie. Deshalb sind Kinder nach wie vor stiefmütterlich behandelt. Jedoch können auch Kinder jedes Alters eine adäquate multimodale Schmerztherapie erhalten.
Comparison of emissions from smokeless coal combustion in a household heating boiler used in Central Europe
Authors: Knigawka P. , Pianko-Oprych P. , Krpec K. , Kuboňová L.
Published: September 2021

The objective of this work was to evaluate the relationship between the fuel quality and the gaseous and particulate pollutant emissions generated from a hot-water boiler during the combustion of different types of innovative processed fuels: smokeless coal, smokeless briquettes 1–3, smokeless pellets and unprocessed hard coal. The aim of our research was to prove the presumption that smokeless processed coals produce less gaseous and particulate emissions. By using modern fuels in already used and manufactured older boilers, there is a possibility to significantly reduce emissions of organic gaseous compounds (OGC) and polycyclic aromatic hydrocarbons (PAHs). The emission situation in the heating season can be significantly improved even without costly production, and thus consumption of natural resources and energy, and installation of modern boilers. Physical and chemical characterization of solid-fuel samples, including determination of moisture content, ash, volatile organic content, calorific value and elemental composition analysis, were performed. Fuels were burned in one type of hot-water boiler class 1 according to EN 303-5 to determine the impact of applied fuel types on pollutant emissions. The pollutant emissions were characterized by the contents of gaseous components: nitrogen oxides NOx, sulfur dioxide SO2, carbon monoxide CO, carbon dioxide CO2, organic gaseous compounds OGC and particle components: total suspended particles TSP, particulate matter less than 2.5 µm and 10 µm (PM2.5 and PM10, respectively) and polycyclic aromatic hydrocarbons PAHs in both phases. The emission factors from six types of fuel were compared with applicable European standards. The lowest NOx content was observed for smokeless briquette 1, while the lowest SO2 content was observed for smokeless pellets. The emission of CO was at a similarly low level of 200 g/kg for smokeless briquette 1, smokeless briquette 2 and hard coal. Gaseous and pollutant emissions described by PM2.5 and TSP were observed to be the lowest for smokeless coal, smokeless briquette 1 and smokeless briquette 2.
Reflections on Research: Race and the Virginia Blue Ridge
Authors: Horning Audrey
Published: September 2021

In the 1930s, Shenandoah National Park was established in the Virginia Blue Ridge through the displacement of nearly 500 white families. In recent decades, my scholarship and that of others focused upon the manner in which hackneyed stereotypes about backward mountaineers were mobilized to garner public support for the condemnation of family farms and, in some cases, the institutionalization, sterilization, and incarceration of some of the most impoverished. But, in focusing solely upon the 20th century and the impacts on the white displaced, this research has perpetrated structural violence by obscuring the role of race and racism in the wider Blue Ridge. Archaeological and documentary evidence from the 1990s National Park Service–funded “Survey of Rural Mountain Settlement” is reexamined and reconsidered to begin the process of redressing the silencing of African American histories in the Blue Ridge and surrounding valley and piedmont regions.
Electric polarization and crystal orientation of lead zirconate titanate under mechanical stress due to embedding in a metal matrix
Authors: Yanaseko Tetsuro , Sato Hiroshi , Narita Fumio , Asanuma Hiroshi
Published: September 2021

The mechanical characteristics of piezoelectric ceramic fibers can be improved by embedding the fibers in a metal matrix. The compressive stress generated during the embedding process, however, limits the polarization of piezoelectric ceramic composites. To study and determine the relationship between the mechanical and piezoelectric properties of piezoelectric ceramics, we analyzed the crystallographic orientation of piezoelectric ceramics embedded in an aluminum matrix via electron backscatter diffraction. The orientation of the crystals before and after the polarization of the piezoelectric fibers, in which residual stresses were generated during embedding, was evaluated. Furthermore, the residual stresses were reduced by heat treatment, and the resultant angle of orientation was evaluated before and after polarization. Results showed that, as the residual stresses were relieved, the orientation of the piezoelectric ceramic crystals changed to reveal increased polarization. Our analysis shows that the crystal orientation of piezoelectric ceramics is impacted by the residual compressive stress that arises from embedding the piezoelectric fiber in the aluminum matrix; it also illustrates the hindering effect of residual stress on the polarization of piezoelectric ceramics.
Scott Thornbury's 101 Grammar Questions
Authors: Thornbury Scott
Published: September 2021

A compact, user-friendly reference book addressing many of the kinds of questions about grammar that regularly confront teachers, both novice and experienced, when planning or executing their lessons. A glance at any web-site, discussion forum or social network shared by teachers of English suggests that teachers are constantly asking each other questions related to pedagogical grammar. These may simply be questions about terminology or categorisation ('What's a clause?'; 'Is like a preposition?'), or they may seek to unravel subtle grammatical distinctions ('What's the difference between for and since?) or explain persistent learner errors ('Why in bed and not in the bed?'). This book is designed to fulfil this basic, everyday need – as well as being a book that can be read for interest, and even pleasure, in its own right.
First Peoples in a New World
Authors: Meltzer David J.
Published: September 2021

Over 15,000 years ago, a band of hunter-gatherers became the first people to set foot in the Americas. They soon found themselves in a world rich in plants and animals, but also a world still shivering itself out of the coldest depths of the Ice Age. The movement of those first Americans was one of the greatest journeys undertaken by ancient peoples. In this book, David Meltzer explores the world of Ice Age Americans, highlighting genetic, archaeological, and geological evidence that has revolutionized our understanding of their origins, antiquity, and adaptation to climate and environmental change. This fully updated edition integrates the most recent scientific discoveries, including the ancient genome revolution and human evolutionary and population history. Written for a broad audience, the book can serve as the primary text in courses on North American Archaeology, Ice Age Environments, and Human evolution and prehistory.
Teaching Languages to Adolescent Learners
Authors: Erlam Rosemary , Philp Jenefer , Feick Diana
Published: September 2021

Teaching languages to adolescents can be a challenge. . . but one that is most rewarding! What works? What doesn't work? This book provides a reader friendly overview on teaching modern languages to adolescents (Years 7–13). Each chapter takes an aspect of language teaching and learning, and explains the underlying theory of instructed language acquisition and its application through examples from real language classrooms. The book explores teachers' practices and the reasoning behind their pedagogic choices through the voices of both the teachers themselves and their students. At the same time, it highlights the needs of the adolescent language learner and makes the case that adolescence is a prime time for language learning. Written in an accessible, engaging way, yet comprehensive in its scope, this will be essential reading for language teachers wishing to integrate cutting-edge research into their teaching. This title is also available as Open Access on Cambridge Core at 10.1017/9781108869812
Hegel and the Challenge of Spinoza
Authors: di Giovanni George
Published: September 2021

Hegel and the Challenge of Spinoza explores the powerful continuing influence of Spinoza's metaphysical thinking in late eighteenth- and early nineteenth-century German philosophy. George di Giovanni examines the ways in which Hegel's own metaphysics sought to meet the challenges posed by Spinoza's monism, not by disproving monism, but by rendering it moot. In this, di Giovanni argues, Hegel was much closer in spirit to Kant and Fichte than to Schelling. This book will be of interest to students and researchers interested in post-Kantian Idealism, Romanticism, and metaphysics.
Between the Pagan Past and Christian Present in Byzantine Visual Culture
Authors: Chatterjee Paroma
Published: September 2021

Up to its pillage by the Crusaders in 1204, Constantinople teemed with magnificent statues of emperors, pagan gods, and mythical beasts. Yet the significance of this wealth of public sculpture has hardly been acknowledged beyond late antiquity. In this book, Paroma Chatterjee offers a new perspective on the topic, arguing that pagan statues were an integral part of Byzantine visual culture. Examining the evidence in patriographies, chronicles, novels, and epigrams, she demonstrates that the statues were admired for three specific qualities - longevity, mimesis, and prophecy; attributes that rendered them outside of imperial control and endowed them with an enduring charisma sometimes rivaling that of holy icons. Chatterjee's  interpretations refine our conceptions of imperial imagery, the Hippodrome, the Macedonian Renaissance, a corpus of secular objects, and Orthodox icons. Her book offers novel insights into Iconoclasm and proposes a more truncated trajectory of the holy icon in medieval Orthodoxy than has been previously acknowledged.
Double Objective in Mind: Translating American Management Ideas in the Context of Cold War Finland
Authors: Seppälä Jarmo , Nevalainen Pasi , Mattila Pekka , Laukkanen Mikko
Published: September 2021

The transfer of American management ideas was a central part of the Cold War struggle over ideologies. A key mediator was the European Recovery Program, which conveyed American influences to European management specialists. However, a direct influence was not always possible, as in Finland, which officially blocked assistance because of foreign policy considerations. Still, it was among the first countries to follow Harvard University’s lead in launching advanced management training. We examine how and why the focal actors adopted the American model of executive education, and how they managed to translate foreign ideas persuasively to the local business elite. The translation of executive education to Finland was a lengthy process that involved modification and readjustment of the original idea according to emerging needs. The Advanced Management Program became the core of the curriculum of Finland’s leading executive education institution and thus has influenced the emergence of new business culture.
A microfluidic methodology to identify the mechanical properties of capsules: comparison with a microrheometric approach
Authors: Wang Xing-Yi , Merlo Adlan , Dupont Claire , Salsac Anne-Virginie , Barthès-Biesel Dominique
Published: September 2021

We present a microfluidic method to measure the elastic properties of a population of microcapsules (liquid drops enclosed by a thin hyperelastic membrane). The method is based on the observation of flowing capsules in a cylindrical capillary tube and an automatic inverse analysis of the deformed profiles. The latter requires results from a full numerical model of the fluid–structure interaction accounting for nonlinear membrane elastic properties. For ease of use, we provide them under the form of databases, when the initially spherical capsule has a membrane governed by a neo-Hookean or a general Hooke's law with different surface Poisson ratios. Ultimately, the microfluidic method yields information on the type of elastic constitutive law that governs the capsule wall material together with the value of the elastic parameters. The method is applied to a population of ovalbumin microcapsules and is validated by means of independent experiments of the same capsules subjected to a different flow in a microrheological device. This is of great interest for quality control purposes, as small samples of capsule suspensions can be diverted to a measuring test section and mechanically tested with a 10 % precision using an automated process.
Variability in antimicrobial use among infants born at <33 weeks gestational age
Authors: Ting Joseph Y. , Roberts Ashley , Abou Mehrem Ayman , Khurshid Faiza , Drolet Christine , Monterrosa Luis , Yoon Eugene W. , Shah Prakesh S.
Published: September 2021

Excessive antimicrobial use is associated with adverse neonatal outcomes. In our cohort of 27,163 infants born at <33 weeks gestational age, the first week after birth accounted for the highest rates of antimicrobial use, and variability across sites persisted after adjustment for patient characteristics correlated with illness severity.
Identifying phenotypic and physiological subgroups of preschoolers with autism spectrum disorder
Authors: Bazelmans Tessel , Jones Emily J. H. , Ghods Sheila , Corrigan Sarah , Toth Karen , Charman Tony , Webb Sara J.
Published: September 2021

Background

To understand the emergence of symptoms in autism spectrum disorder (ASD), we need to identify the mechanisms that underpin the development of core social skills. Mounting evidence indicates that young children with later ASD attend less to other people, which could compromise learning opportunities with cascading effects. Passive looking behaviour does not tell us about engagement with visual information, but measures of physiological arousal can provide information on the depth of engagement. In the current study, we use heart rate (HR) and heart rate variability (HRV) to measure engagement with social dynamic stimuli in ASD.

Methods

Sixty-seven preschoolers with ASD and 65 typical developing preschoolers between 2 and 4 years of age participated in a study where HR was measured during viewing of social and non-social videos. Using latent profile analyses, more homogeneous subgroups of children were created based on phenotype and physiology.

Results

Preschool-aged children with ASD, regardless of their non-verbal, verbal and social competencies, do not differ in overall HR or HRV compared to TD children. However, the ASD group showed a larger increase in HR (more disengagement) than the TD group to later-presented social stimuli. Phenotypic and physiological profiles showed this was primarily the case for children with below average verbal and non-verbal skills, but not necessarily those with more ASD symptoms.

Conclusion

Children with ASD, especially a subgroup showing moderate cognitive delays, show an increase in HR to social stimuli over time; this may reflect difficulties re-engaging with social information when attention is waning.
‘Use your words’: Vocalization and moral order in an oral preschool classroom for deaf or hard-of-hearing children
Authors: Montiegel Kristella
Published: September 2021

This ethnographic study examines deaf or hard-of-hearing children's socialization in an oral classroom, a setting designed to promote spoken language as the primary mode of communication. Drawing from nine months of observations, I describe how the meanings assigned to children's vocalizations create a system of values and judgements that organizes and regulates classroom behavior. Specifically, vocalization itself is oriented to as a moral practice that is necessary for the mutual understanding and accomplishment of classroom activities. Informed by ethnomethodological and language-socialization perspectives, I illustrate how participants co-construct a local moral order wherein students are held accountable for ‘using their words’ to perform social actions. Analyses discuss three interactional contexts where moral issues are routinely constructed as contingent on and resolvable through vocalization—children's help-seeking, children's disputes, and negotiations of classroom participation—thereby shaping children's understanding of language use and reflecting broader institutional expectations and ideology regarding oral communication. (Moral order, preschool children, socialization)*
Ordering and aging properties of systems with dependent components governed by the Archimedean copula
Authors: Sahoo Tanmay , Hazra Nil Kamal
Published: September 2021

Copula is one of the widely used techniques to describe the dependency structure between components of a system. Among all existing copulas, the family of Archimedean copulas is the popular one due to its wide range of capturing the dependency structures. In this paper, we consider the systems that are formed by dependent and identically distributed components, where the dependency structures are described by Archimedean copulas. We study some stochastic comparisons results for series, parallel, and general $r$-out-of-$n$ systems. Furthermore, we investigate whether a system of used components performs better than a used system with respect to different stochastic orders. Furthermore, some aging properties of these systems have been studied. Finally, some numerical examples are given to illustrate the proposed results.
An unusual case of concurrent Kounis syndrome and prolonged QT in a young patient
Authors: Erdogan Emrah , Cap Murat , Kus Gorkem , Gokhan Cem , Kilic Yakup
Published: September 2021

Allergic reactions related to drug use is a common entity presenting often from minor urticaria to life-threatening anaphylactoid reactions. A common but easily overlooked diagnosis, Kounis syndrome, is an established hypersensitivity coronary disorder induced by drugs, foods, environmental factors, and coronary stents that can present in the same way as non-allergy-induced acute coronary syndrome. Here within, we present a unique case of dual presentation of Kounis syndrome and prolonged QTc in a young patient after a single dose of Domperidone and Lansoprazole.
Retracted: Earth System Model Analysis of How Astronomical Forcing Is Imprinted Onto the Marine Geological Record: The Role of the Inorganic (Carbonate) Carbon Cycle and Feedbacks
Authors: Vervoort Pam , Kirtland Turner Sandra , Rochholz Fiona , Ridgwell Andy
Published: September 2021

Astronomical cycles are strongly expressed in marine geological records, providing important insights into Earth system dynamics and an invaluable means of constructing age models. However, how various astronomical periods are filtered by the Earth system and the mechanisms by which carbon reservoirs and climate components respond, particularly in absence of dynamic ice sheets, is unclear. Using an Earth system model that includes feedbacks between climate, ocean circulation, and inorganic (carbonate) carbon cycling relevant to geological timescales, we systematically explore the impact of astronomically modulated insolation forcing and its expression in model variables most comparable to key paleoceanographic proxies (temperature, the δ13C of inorganic carbon, and sedimentary carbonate content). Temperature predominately responds to short and long eccentricity and is little influenced by the modeled carbon cycle feedbacks. In contrast, the cycling of nutrients and carbon in the ocean generates significant precession power in atmospheric CO2, benthic ocean δ13C, and sedimentary wt% CaCO3, while inclusion of marine sedimentary and weathering processes shifts power to the long eccentricity period. Our simulations produce reduced pCO2 and dissolved inorganic carbon (DIC) δ13C at long eccentricity maxima and, contrary to early Cenozoic marine records, CaCO3 preservation in the model is enhanced during eccentricity‐modulated warmth. Additionally, the magnitude of δ13C variability simulated in our model underestimates marine proxy records. These model‐data discrepancies hint at the possibility that the Paleogene silicate weathering feedback was weaker than modeled here and that additional organic carbon cycle feedbacks are necessary to explain the full response of the Earth system to astronomical forcing.
Geochemically Defined Mean Position of the Intertropical Convergence Zone in the Central Pacific
Authors: Seo Inah , Kim Mun Gi , Yoo Chan Min , Hyeong Kiseong
Published: September 2021

The Intertropical Convergence Zone (ITCZ) is a band of vigorous convection and high precipitation formed by the confluence of southeasterly and northeasterly trade winds, and acts as a barrier to cross‐equatorial dust transport. We investigate the provenance of dust in the surface sediments of 16 cores collected along a 131.5°W transect from the equator to 16°N in the central Pacific. The results reveal well‐defined Asian dust signals north of 7°N and mixed Asian–South American source signals south of 6°N. We propose the southernmost latitude with an intact Asian source signal (7°N) as the present‐day mean ITCZ position in terms of dust provenance in the central Pacific. This geochemically defined mean ITCZ position reflects differences in thermal and dust fluxes between hemispheres and can be used as a reference for quantitatively assessing ITCZ displacement in the sedimentary down‐core records back to ca. 14 Ma.