bluuebunny/crossref_metadata_2025 huggingface dataset:
Trans-septal quilting suture versus intranasal silicone splint for preventing complications post endoscopic septoplasty
Authors: Al Muslem Rana F. , Al Eid Mohammad R. , Al Baharna Hussain A.
Published: August 2021

Background: Septoplasty is a common procedure in the field of otolaryngology for treatment of septal deviations. Intranasal splints and trans-septal quilting suture are commonly utilized to prevent post-operative complications. The silicone splint is a quick and simple technique to aid in cartilage support; however, it can cause discomfort. Trans-septal quilting suture is more available, well-tolerated and can help in mucosal tear closure, though is time-consuming. This study aimed to compare the efficacy of intranasal silicone splints versus quilting suture in the prevention of post endoscopic septoplasty complications.

Methods: This was a retrospective COHORT study comprised of patients who underwent endoscopic septoplasty between January 2017 and December 2019 at Qatif central hospital. The patients were assigned into two groups: group S, who received intranasal splints and group Q, who received trans-septal quilting suturing. Patients’ medical records were reviewed for evaluation of post-operative visits and post-operative nasal endoscopic video recordings from the image archive software were evaluated to document complications. Statistical analysis was conducted using SPSS 23.0 software.

Results: The study included 65 patients, of whom 41 were in group S and 24 were in group Q. None of the patients had major bleeding, local infection or mucosal synechia. There was a higher complication rate in terms of mucosal crustation, septal hematoma and perforation among group S; however, the difference was not statistically significant.

Conclusions: We conclude that trans-septal quilting suture and intranasal silicone splints are both equally effective in preventing complications following septoplasty.
Extrapulmonary head and neck tuberculosis: 3 year experience at a tertiary care centre
Authors: Vivekanand Ashok , Fernandes Prajwal S. , Tara Nair
Published: August 2021

Background: Tuberculosis (TB) is a disease caused by Mycobacterium group of microbe. Most common manifestation of the disease is pulmonary TB. Involvement of other sites is termed as extrapulmonary TB (EPTB). These extrapulmonary sites are head and neck region, renal system, pleura, central nervous system and bones. This study was to find out the various head and neck manifestations of TB.

Methods: All head and neck cases of TB diagnosed during the period 2017-2020 were included in the study. Recurrent cases of TB and those patients with primary pulmonary TB focus having head and neck manifestation were excluded from the study.

Results: 63 patients fulfilled the inclusion and exclusion criteria. The disease was found to be more in females (65.07%). The most common EPTB manifestation in head and neck region was the involvement of cervical lymph nodes followed by laryngeal TB. Level II was the most common involved lymph node group. We noted three cases of temporal bone TB and one case of nasal TB.

Conclusions: In regions where the disease is endemic, there can be various atypical clinical presentations. Early diagnosis is of utmost importance in initiation of appropriate treatment.
Case analysis and systematic review of aspergilloma
Authors: Benitha J. Georgia , Ramani Prathiba , Krishnan Reshma Poothakulath , S. Gheena , R. Abhilasha
Published: August 2021

Among various fungal pathogens, Aspergillus fumigatus is the most prevalent human pathogen reported to cause human disease such as aspergilloma or aspergillosis. Aspergillomas are commonly seen in a poorly drained and avascular cavitary space which evokes an inflammatory reaction. Most commonly involving paranasal sinuses especially maxillary sinus. For the past 2 decades incidence of aspergillosis has increased substantially. The main objective of this systematic review was to evaluate the cases reported to be aspergilloma of maxillary sinus and to determine the percentage of cases involving aspergilloma of maxillary sinus in healthy individuals. After the final full text review, 16 articles were included in this systematic review. Data were extracted from the full text articles and reviewed and extracted content. About 83% had a history of dental procedures, with 42% of those being due to infection from previous extraction sockets and 41% due to RCT. About 43% of the patients in this study were immunocompromised, while 56% were healthy and had no known predisposing conditions. The aspergillus fungal infections affecting the paranasal sinuses are common which can affect apparently healthy as well as immunocompromised individuals. Aspergilloma is the most common fungal infection involving maxillary sinus with iatrogenic dentogenic factors being the most predominant factor for the initiation and progression of aspergillus fungal infection. About 43% of the patients in this review were immunocompromised patients whereas 56% of the patients were healthy without any known predisposing conditions. The progression and prognosis of these diseases depends on the location and immunologic status of the patient. So, it is very important for the dentists to be more cautious while performing any dental procedures so as not to initiate any iatrogenic infections.
Dermatology life quality index in patients of acne vulgaris presenting to a tertiary care hospital: an observational study
Authors: Kundale Darshana R. , Gosavi Anil P. , Chavan Ravindranath B. , Bhatt Neelamkumari
Published: August 2021

Background: Acne vulgaris is a common, chronic disorder resulting from the inflammation of pilosebaceous unit, present with clinically various forms. It is usually prevalent in adolescent may persist in adulthood. This study was conducted to evaluate the quality of life (QoL) in patients suffering from acne vulgaris.

Methods: Hospital based cross sectional study was conducted in 60 patients. Dermatology life quality index (DLQI) questionnaire was used to observe the effect of acne among patients.

Results: Total numbers of patients enrolled were 60 (43 females,17 males). The mean age was 24.85±5.63 years. Maximum patients were of the age group 26-30 years (22 patients; 36%) and least were of 31-36 age group. Out of 60 patients, 29 patients had grade II acne followed by 20 with grade I acne, grade III acne was present in 11 patients. Most of the patients 31 (52%) were having “moderate impact” on quality of life followed by 23 (38%) with “small impact” on QOL. There was a significant positive correlation between grade of acne and DLQI (Pearson correlation=0.753, p=0.00).

Conclusions: Our study showed significant impairment of QoL in acne patients. DLQI increases with increase in severity of acne. Treatment of acne should not be guided only by the clinical grade of acne, but take into consideration the psychosocial impact the condition has on the patient. Adequate counselling along with early treatment of acne vulgaris is essential in order to reduce the disease related psychosocial sequelae and increase treatment efficacy.
A case report of generalised eruptive syringoma: a rare variant of syringoma
Authors: Devaraj Yogesh , Mukunda Ranga Swaroop , Yadav Priyanka Yogananda , Kalra Taranpreet Kaur , Obeidullah Shaik Mohammed
Published: August 2021

Syringomas are benign adnexal neoplasm of eccrine sweat duct usually affecting adult women. They present as firm, skin coloured to yellowish papules in a symmetrical distribution over periorbital region. Eruptive syringomas are infrequent and usually appear at uncommon sites. Herein, we report a case of a 21-year old girl with eruptive syringomas with an extensive involvement.
Increased first trimester serum uric acid as a predictor of Gestational diabetes mellitus
Authors: Gopalan Ushadevi , Sivasarupa Irkm , Kumarapillai Sivankumar
Published: August 2021

Women with raised uric acid in pregnancy are interlinked with more incidence of unfavourable outcomes in pregnancy such as gestational diabetes mellitus. The study aims at testing the hypothesis that elevated uric acid in first trimester of pregnancy is associated with subsequent development of gestational diabetes.

: All pregnant women less than 12 weeks were included in this study after informed consent. Blood samples were collected for serum uric acid analysis and all these patients were followed up with oral glucose tolerance test at twenty-four to twenty-eight weeks of gestation.

The mean age of pregnant women was 29.84 ± 4.94 years. The mean height and weight was 151.52 ± 7.49 cms and 50.60 ± 6.88 kg respectively. The body mass index of patients was 22.13 ± 3.31 kg/m.The mean gestational age of pregnant women was 11.14 ± 1.30 weeks. The mean uric acid level was 3.81 ± 1.24 mg/dl. In this study the p value was 0.018 using chi-square test which was significant.

Hyperuricemia in first trimester is a reliable marker for the prediction of gestational diabetes mellitus in later pregnancy.
Observational study of Y chromosome microdeletion, EAA markers and non EAA markers in Chhattishgarh
Authors: Sinha Manisha B , Patel Suprava , Bagde Nilaj , Sinha H P , Joshi Apoorva
Published: August 2021

Genetic factors contribute to 15% of all causes of male infertility. Y chromosome microdeletion is the second most common genetic cause of male infertility. Screening is important for Yq microdeletion as the defect can be transferred to offspring. Aim of our study is to detect the frequency of Y chromosome microdeletion in idiopathic infertile men using both EAA and non EAA markers in central region of India. Forty men from infertility clinic, seeking treatment of infertility were recruited in the study as cases. Thirty normal fertile men of same origin were recruited as controls. Semen analysis was done and cytogenetic normal infertile men were included in the study. Simplex and multiplex PCR methods were used to detect Yq microdeletions. Frequency of deletion was 11/40 (27.5%). Single deletion of AZF a,b,c were 12.5%, 7.5%, 2.5% respectively (). Double deletions of AZF a+c and b+c were 2.5% each (). Two subjects showed deletion for more than one loci. Overall frequency of deletion depends on sample size, no of markers used, inclusion criteria of subjects and geographic location. So, the screening is important for Yq microdeletion as the defect may be inherited to offspring.
Comparative study of obstetric outcome in women with one previous spontaneous miscarriage versus women with one previous normal delivery
Authors: Gangatkar Pallavi R , Rafique Sulthana Asma , Ravikanth G O
Published: August 2021

Spontaneous abortion is unintentional pregnancy loss before 20 weeks of gestation. This study was done to find out the association between one spontaneous pregnancy loss and adverse pregnancy outcomes in the subsequent pregnancy and to compare these pregnancy outcomes in patients with prior one full term normal delivery.

: It is a case control study. 70 G2A1 were taken as cases, 70 G2P1L1 were considered as Control. The adverse pregnancy outcomes like preterm labour, PROM, IUGR and oligohydramnios and neonatal outcomes like poor Apgar score, low birth weight, NICU admissions and neonatal complications were noted compared and analysed between the two groups. Chi-square was used to find association between clinical variables. Independent t-test was used to compare the outcome measures between the groups.

: Comparing the pregnancy outcomes of the case and control groups case group had a higher number adverse pregnancy or neonatal outcome, compared to the control group (p value = 0.05), adverse outcome were higher in case population, adverse outcomes which were independently associated with initial spontaneous abortion were oligohydramnios (p = 0.02), GDM (p = 0.05), LSCS (p = 0.01), low birth weight (p = 0.03), low Apgar scores 1 minute (p = 0.009), low Apgar score at 5 minute (p = 0.03) and babies requiring NICU care (p = 0.001).

: Study shows that there is increase in adverse obstetric and perinatal outcomes in pregnancies which are following a single spontaneous abortion. Hence a prior spontaneous miscarriage is a risk factor for the adverse outcome in subsequent pregnancy, therefore careful prenatal care in such pregnancies are mandatory to avoid adverse pregnancy outcomes.
Pregnancy with double outlet right ventricle in university Airlangga hospital Surabaya
Authors: Wonodihardjo Andy Sugiharto , Gumilar Khanisyah Erza , Akbar M. Ilham Aldika
Published: August 2021

Present a case of a successful pregnancy in a patient with Double Outlet Right Ventricle (DORV).

A case report of 36 year old pregnant woman with DORV that underwent Cesarean Delivery in University Airlangga Hospital Suurabaya.

Participant: A pregnant 36-year-old patient with a DORV. This patient does not aware if she has Cardiac Disease but patient often complaining easy fatigability after doing light work and developed cardiac symptoms, such as dyspnea since 28 weeks Age of Gestation. Once the symptoms developed, patient was referred to Secondary hospital in Bojonegoro, echocardiography was done and patient was diagnosed with DORV. Since DORV is rare case and complicated, after that patient referred to Airlangga Hospital for further evaluation and treatment. Patient was admitted for 9 days, corticosteroid for lung maturity was given and underwent elective C-Section under epidural anesthesia on 34/35 age of gestation. Course in the ward was unremarkable and patient was discharged post operative day 3.

This patient was diagnosed with DORV Subaortic Type and underwent cesarean delivery without complication and delivered baby boy without any congenital anomaly from physical examination. The systemic circulation from this patient was balanced until third trimester because the increase of blood volume.
Syphilis in pregnancy: The menace continues to haunt
Authors: Jhirwal Manisha , Sharma Charu , Shekhar Shashank , Tak Apoorva , Elhance Poonam
Published: August 2021

Syphilis in pregnancy remains an important medical condition due to its adverse perinatal consequences and potential to cause congenital syphilis. The cases of congenital syphilis have been reported worldwide as there is increase in cases of syphilis in women. We hereby present a case of 34-year-old multigravida who was diagnosed with syphilis during her first antenatal visit in second trimester and managed. The baby did not show any signs of congenital syphilis. This report highlights the diagnostic workup, management and possible complications of syphilis in pregnancy.

 Universal screening of all pregnant women at first antenatal visit with a non-treponemal test should be used for screening for syphilis in pregnancy.
Child trafficking in surrogacy
Authors: Chudaykin Evgeny
Published: August 2021

Surrogacy is a relatively new institution not only for the law of order, but also for society. This results in forming of not at all right perception of certain aspects of this institution of both society and law enforcer. In particular, surrogacy is compared to the buying and selling of a child, that is not right and will be proved in present article.
Factors Influencing Tourist Visit in North Sulawesi, Indonesia
Authors: Mananeke Lisbeth , Machmud Rizan
Published: August 2021

This study aims to determine the factors that influence the level of tourism visit on several tourism destinations in North Sulawesi Province. The research method used in this research is quantitative. Population in this study is people or tourist that visited any tourism attraction in North Sulawesi Province. The sample size of 100 respondents is the visitors of the tourism attraction in North Sulawesi Province. Data analysis using linear regression test using SPSS. The results showed that the characteristics of the respondents were generally male, namely 55%, the level of education, namely Senior High School with 68%, The respondents in age between 21-30 years old are 70 respondents or contributed 70%. Attraction factors, price, promotion, and security are significantly influence on tourist visit, and on the other hand, place doesn’t have a significant influence because place is closely related to the mileage. The result of this research can be a reference for Tourism Department of North Sulawesi considering the Promotion (X4) as the strongest variable that can improve the tourist visit level in North Sulawesi Province.
Body Image Perceptions and Body Image Dissatisfaction among Medical Students in Oman
Authors: Divecha Chhaya A , Simon Miriam A , Asaad Alhasan A , Tayyab Hassan
Published: August 2021

Objectives: To study body image perceptions and body image dissatisfaction, and their relationship with Body Mass Index (BMI) among medical students in Oman. Methods: A cross-sectional study was conducted among students of a private medical college in Oman. Data (including self-reported weight and height) was collected through a questionnaire-based survey. Body image perception and satisfaction were assessed using Stunkard Figure Rating Scale (FRS).. Students' responses were collected, analyzed, and interpreted. Results: A total of 351 medical students participated in the study (mean age of 21.6 + 2.2 years, mean BMI of 22.7 + 4.3 kg/m 2 ). Most students were within normal ranges of BMI (63%), 12% were underweight and 25% overweight/ with obesity. Around 66% of students perceived their body image correctly; students at extremes of BMI were more accurate about their body image perceptions. Body image dissatisfaction was high (80%) among the respondents ; 73.5% 0f those dissatisfied desired to be thinner. The association between self-reported BMI with perceived BMI and body image dissatisfaction was significant (p<0.001). Only 18.2% of students felt "attractive". The association between body image perception and body image dissatisfaction was statistically significant (p<0.05). Conclusion: A high degree of body image dissatisfaction and incorrect body image perceptions exists among medical students. There is an increased desire to be thinner and a majority feel unattractive. There is a need to foster healthy body image perceptions among students of health sciences as they are the future in healthcare and can influence the health beliefs in our society.

Keywords: Body Image Perception; Body Image Dissatisfaction; Body Mass Index; Medical Students.
Oficinas como ferramentas para ensino de primeiros socorros no ensino médio
Authors: Arruda-Barbosa Loeste de , Salhah Safi , Vasconcelos Iara Guilhermina , Sales Alberone Ferreira Gondim , Sales Márcia Cristina
Published: August 2021

Objetivo: descrever a experiência de um projeto de extensão que utiliza oficinas de PS como ferramenta de educação em saúde direcionado ao ensino de PS a estudantes de ensino médio. Assim, acadêmicos de medicina desenvolveram oficinas dirigidas a estudantes de ensino médio de escolas públicas da cidade de Boa Vista, Roraima. O processo educativo foi divido em quatro etapas: I- exposição das situações mais frequentes de PS; II- avaliação prévia dos conhecimentos dos participantes com perguntas relacionadas a situações de PS; III- exposição teórico-prática das técnicas e condutas em situações de PS; IV- avaliação da compreensão e reprodução das técnicas trabalhadas. Percebeu-se despreparo da população frente às emergências: condutas expostas, majoritariamente, basearam-se erroneamente na crença popular, sem respaldo científico. Todavia, participantes correlacionaram experiências prévias, permutaram conhecimentos e expuseram argumentos, conforme os princípios horizontais dessa intervenção teórico-prática. Houve grande interesse nas práticas, contribuindo para uma participação exitosa dos integrantes que demonstraram aprender conhecimentos confirmados após comparação dos pré e pós-testes, portando-se adequadamente diante emergências. Conclui-se que os estudantes de ensino médio trabalhados em Boa Vista carecem de noções básicas e de intervenções de ensino de PS, porém, há interesse desse público nessa temática que, quando trabalhadas com metodologias teórico-práticas horizontais e interativas, permitem que as noções básicas em PS sejam aprendidas de modo efetivo. Experiências como essa, escassas no estado de Roraima, podem contribuir como incentivos para outras universidades, principalmente no Norte do Brasil, para o desenvolvimento de projetos de extensão similares, fortalecendo, assim, o papel social das universidades.
Aprendizagem ativa e híbrida na formação médica sobre Políticas Públicas de Saúde
Authors: Maia Ivana Cristina Vieira de Lima , Peixoto Maria das Graças Barbosa , Medeiros Diego da Silva , Arruda Gisele Maria Melo Soares , Neto Franklin de Castro Alves , Santos Elton Rodrigues
Published: August 2021

Objetivou-se descrever a experiência relacionada à aprendizagem ativa e híbrida na formação médica sobre políticas públicas de saúde em uma instituição pública estadual de ensino superior.  A disciplina foi ofertada no período de dezembro de 2019 a abril de 2020 no 4º semestre do Curso de Medicina para uma turma constituída por 36 discentes. As principais metodologias ativas utilizadas na condução da disciplina foram: Sala de Aula Invertida (Flipped Classroom), Aprendizagem Baseada em Problemas (PBL), jogo educativo e aprendizagem baseada em projetos. O ensino híbrido consistiu no uso do Google Classroom, um sistema de gerenciamento de conteúdos com a finalidade de compartilhar materiais para leitura, explicar e receber atividades, bem como avaliar a aprendizagem. Ao final da disciplina foi realizada uma avaliação institucional por meio do Google Forms para apreender a percepção dos discentes sobre os métodos de ensino e aprendizagem, os professores e a contribuição para a formação médica, além de captar os pontos positivos, negativos e sugestões. As metodologias ativas de aprendizagem e o ensino híbrido proporcionaram integração teórico-prática dos conteúdos; maior engajamento e participação ativa do discente; fortalecimento do trabalho colaborativo; ambiente sensibilizador e motivador para a aprendizagem; feedback contínuo e qualidade na gestão da aprendizagem. Contudo, foram apontadas como desvantagens a alta carga de atividades didáticas e a sobrecarga dos discentes mais dedicados nas atividades em grupo, o que demonstra a importância do papel docente como mediador da aprendizagem.
Importância do farmacêutico na Comissão de Controle de Infecção Hospitalar
Authors: Da Silva Paulo Fernando , Machado Barbosa Francisco Eduardo , Da Costa Alves Maria Valdiana , Braga Rolim Vieira Renata , Vitoriano de Sousa Roberto Sara
Published: August 2021

A infecção hospitalar é um importante problema de saúde pública que é responsável por elevados números de complicações dos pacientes hospitalizados. Diante disso, surge a Comissão de Controle de Infecção Hospitalar (CCIH), que está voltada à prevenção e ao controle da infecção no ambiente hospitalar, sendo que ela possui o objetivo de prevenir e combater a infecção hospitalar. Assim, a presente pesquisa teve como objetivo verificar a importância do farmacêutico na Comissão de Controle de Infecção Hospitalar. Revisão integrativa da literatura, descritiva, com abordagem qualitativa. Foi possível verificar que o farmacêutico possui papel importante na CCIH, pois desenvolve ações estratégicas como criação de rotinas para a dispensação de medicamentos, a seleção e padronização de antibióticos e ainda a promoção racional do uso de medicamentos. Desse modo, o farmacêutico destaca-se como um profissional importante e deveras atuante no funcionamento da Comissão de Controle de Infecção Hospitalar.
Soroprevalência de testes não-treponemicos em instituições públicas em Avaré-SP
Authors: Liutti Maria Eduarda , Vieira Taynara Aparecida , Ciriaco Viviane Aparecida de Oliveira , Bannwart Castro Camila Ferreira , Minatel Igor Otavio , Ianni Tânia Maria Diniz
Published: August 2021

A sífilis é uma infecção sexualmente transmissível (IST), causada pela bactéria Treponema pallidum, que acomete homens e mulheres. Apesar da relação sexual sem o uso de preservativos ser a principal forma de infecção, a transmissão congênita durante a gestação ou parto têm crescido nos últimos anos. O diagnóstico da sífilis pode ser realizado pelos testes treponêmicos e não-treponêmicos. O objetivo do presente estudo foi determinar a soroprevalência de testes não-treponêmicos, em duas Comunidades Terapêuticas de Avaré/SP, e aplicar um questionário social para avaliar o nível de conhecimento dos voluntários quanto as ISTs. O sangue foi coletado por venopunção, para realização da técnica de Venereal Disease Research Laboratory (VDRL) qualitativo e semi-quantitativo, além de teste rápido treponêmico específico para confirmação dos exames reagentes. Os resultados obtidos foram de 41 voluntários que estavam na faixa etária de 22 a 58 anos, onde 36,6% eram mulheres e 63,4% eram homens. As mulheres tinham mais conhecimento a respeito da sífilis do que os homens. Sobre os métodos de prevenção, 23,1% dos homens e 73,3% das mulheres disseram ter conhecimento sobre a forma correta de prevenção. Porém, aproximadamente metade deles afirmaram que não utilizavam preservativos durante o ato sexual. Dos testes realizados, 4,9% (2 voluntários) foram reagentes para sífilis. A maioria dos indivíduos não possuíam um conhecimento razoável sobre as ISTs, e, além disso, não utilizavam preservativos durante as relações sexuais, favorecendo, assim, a exposição e transmissão da sífilis.
Utilização de materiais lúdicos no ensino de Toxicologia Médica para acadêmicos de Medicina
Authors: Rocha Anne Karoline de Araújo , Ciarlini Juliana Costa , BACHUR TATIANA PASCHOALETTE RODRIGUES
Published: August 2021

A Toxicologia é a ciência que se ocupa da natureza, dos mecanismos das ações tóxicas e da avaliação das alterações biológicas produzidos pela exposição do organismo às substâncias químicas. Embora as intoxicações sejam uma causa mundial frequente de procura pelos serviços de saúde, somente em 2002 surgiu, nos Estados Unidos, a Residência Médica em Toxicologia, como ultraespecialização dentro da Medicina Intensiva. Diante do perfil epidemiológico dos envenenamentos, algumas universidades nacionais têm instituído a Toxicologia Médica como disciplina, optativa ou obrigatória, nos cursos de Medicina. Todavia, o ensino dessa disciplina, assim como de muitas outras, mostra-se ainda muito pragmático e tradicionalista, havendo a necessidade de implementação de metodologias mais dinâmicas de ensino, a fim de permitir, aos discentes, melhor compreensão do conteúdo de modo a auxiliá-lo na sua prática profissional. O objetivo do presente trabalho é descrever as experiências de discentes na monitoria  acadêmica na disciplina de Toxicologia Médica em um curso de Medicina de uma Universidade Estadual brasileira, ressaltando a importância da utilização de materiais lúdicos para efetivação da aprendizagem desta disciplina Foram apresentados os materiais lúdicos utilizados nas aulas de Toxicologia Médica: cordel, palavras-cruzadas, quiz, paródia e estudos dirigidos. A aplicação da ludicidade em aulas de toxicologia viabiliza um melhor processo de significação e de aprendizagem tanto para discentes-monitores quanto para discentes-monitorados, desenvolvendo as habilidades de ambas as partes, tanto do monitor - que se aproxima da docência -, quanto do monitorado - que consegue assimilar o assunto de forma menos pragmática, mais didática e, consequentemente, mais efetiva.
Atividades esportivas para indivíduos com transtorno do espectro autista
Authors: Sousa Milena Nunes Alves de , Sousa Michelline Nunes Alves de , Bezerra André Luiz Dantas
Published: August 2021

Objetivou-se identificar as implicações das atividades esportivas para indivíduos com transtorno do espectro autista (TEA). Adotou-se o método de Revisão Integrativa de Literatura, com buscas entre outubro de 2020 e janeiro de 2021 na Biblioteca Virtual em Saúde, World Wide Science, U. S. National Library of Medicine e Scientific Electronic Library Online. A partir dos Descritores em Ciências da Saúde “Transtorno Autístico” OR “Transtorno do Espectro Autista” AND Esportes, apenas seis se enquadraram nos critérios de inclusão e exclusão: texto disponível completo (artigos e resumos expandidos), em português, inglês e espanhol e publicações sem recorte temporal. Os resultados indicaram implicações positivas decorrentes da prática de atividades esportivas para indivíduos com TEA. Os benefícios são de natureza psicossocial (47,06%), física (47,06%) e cognitiva (5,88%). Pelos achados, embora tenha se percebido carências de pesquisas sobre o objeto de estudo, deve-se estimular a participação ativa dos indivíduos com TEA em atividades físicas e esportivas. Ademais, o profissional de Educação Física tem importância fundamental neste processo, sendo indispensável sua atuação junto ao grupo.
Activation of epithelial-mesenchymal transition process during breast cancer progression – the impact of molecular subtype and stromal composition
Authors: Markiewicz Aleksandra , Topa Justyna , Popęda Marta , Szade Jolanta , Skokowski Jarosław , Wełnicka-Jaśkiewicz Marzena , Żaczek Anna
Published: August 2021

Breast cancer (BC) is a heterogeneous disease with different molecular subtypes, which can be defined by oestrogen (ER), progesterone (PR) and human epidermal growth factor (HER2) receptors’ status as luminal, HER2+ and triple negative (TNBC). Molecular subtypes also differ in their epithelial-mesenchymal phenotype, which might be related to their aggressiveness, as activation of the epithelial-mesenchymal transition (EMT) is linked with increased ability of cancer cells to survive and metastasize. Nevertheless, the reverse process of mesenchymal-epithelial transition was shown to be required to sustain metastatic colonization. In this study we aimed to analyse activation of the EMT process in primary tumours (PT), which have (N+) or have not (N–) colonized the lymph nodes, as well as the lymph nodes metastases (LNM) themselves in 88 BC patients. We showed that luminal N– PT have the lowest activation of the EMT process (27%), in comparison to N+ PT (48%, p=0.06). On the other hand, TNBC do not show statistically significant EMT activation at the stage before lymph colonization (N–, 83%) and after colonization of the lymph nodes (N+, 63%, p=0.58). TNBC are also the least plastic (unable to change the EMT phenotype) in terms of turning EMT on or off between matched PT and LNM (0% EMT plasticity in TNBC vs 36% plasticity in luminal tumours). Moreover, in TNBC activation of EMT was correlated with increased cell division rate of the PT– in mesenchymal TNBC PT median Ki-67 was 45% in comparison to 10% in epithelial TNBC PT (p=0.002), whereas in PT of luminal subtypes Ki-67 did not differ between epithelial and mesenchymal phenotypes. Profiling of immunotranscriptome of epithelial and mesenchymal luminal BC with Nanostring technology revealed that N– PT with epithelial phenotype were enriched in inflammatory response signatures, whereas N+ mesenchymal cancers showed elevated MHC class II antigen presentation. Overall, activation of EMT changes during cancer progression and metastatic colonization of the lymph nodes depending on the PT molecular subtype and is related to differences in stromal signatures. Activation of EMT is associated with colonizing phenotype in luminal PT and proliferative phenotype of TNBC.
Cloning, expression in Komagataella phaffii, and biochemical characterization of recombinant sequence variants of Pseudomonas sp. S9 GDSL-esterase
Authors: Wicka-Grochocka Monika , Cieśliński Hubert , Wanarska Marta
Published: August 2021

Two recombinant Komagataella phaffii (formerly Pichia pastoris) yeast strains for production of two sequential variants of EstS9 esterase from psychrotolerant bacterium Pseudomonas sp. S9, i.e. αEstS9N (a two-domain enzyme consisting of a catalytic domain and an autotransporter domain) and αEstS9Δ (a single-domain esterase) were constructed. However, only one of recombinant K. phaffii strains, namely Komagataella phaffii X-33/pPICZαestS9Δ, allowed to successfully produce and secrete recombinant αEstS9Δ enzyme outside of the host cell. The purified αEstS9Δ esterase was active towards short-chain p-nitrophenyl esters (C2–C8), with optimal activity for the acetate (C2) ester. The single-domain αEstS9Δ esterase exhibits the highest activity at 60oC and pH 9.5. In addition, the enzyme retains 90% of its activity after 3 hour incubation at 70–90oC. What should be also noted is that αEstS9Δ esterase produced in the K. phaffii expression system has a much higher specific activity (0.069 U/mg of protein) than the recombinant EstS9Δ esterase produced in an E. coli expression system (0.0025 U/mg of protein) (Wicka et al., 2016, Acta Biochim Pol 63: 117–125. https://doi.org/10.18388/abp.2015_1074).
Stability of Non-Hyperbolic Equilibrium Point for Polynomial System of Differential Equations
Authors: Hadžiabdić Vahidin , Mehuljić Midhat , Bektešević Jasmin
Published: August 2021

In this paper, a polynomial system of plane differential equations is observed. The stability of the non-hyperbolic equilibrium point was analyzed using normal forms. The nonlinear part of the differential equation system is simplified to the maximum. Two nonlinear transformations were used to simplify first the quadratic and then the cubic part of the system of equations.
Optimization of Crude Oil Transfer by Trucking Services with Agent Based Modelling
Authors: Amelia Nurma , F Ferliadi , Christa Avid , E Gunawan Fergyanto , Asrol Muhammad
Published: August 2021

Transportation and distributions network hold an important role to maintain business stability in oil and gas industry. In this work, the simulation modelling to optimize the transportation is proposed for the oil and gas company. An agent-based modelling is developed to find the optimal solutions. Two route alternatives of the transportation were found as the constraint of the model. The result showed that the simulations model enabled to find the number of the truck to operate as the optimal transportation solution. The simulation model demonstrated that the route 2 provided the optimal solution in minimizing transportation cost and maximized the number of distributed crude oil.
A New Potential Indicator in Differentiating Patients with Lumbar Spinal Stenosis and Lumbar Intervertebral Disc Degeneration
Authors: Eskandari Faezeh , Bahramizadeh Sajadi Shima , Katoozian Hamid Reza
Published: August 2021

Background: Center of pressure (CoP) trajectory is one of the gait parameters that is widely used for clinical assessments. Moreover, the CoP trajectory could be adversely affected by anatomic and mechanical factors that involve foot function, which was shown to be correlated with musculoskeletal diseases. The aim of this study is to compare angle-associated parameters of gait in patients with different lumbar spinal disorders.
Methods: The subjects suffered from the same levels of spine impairment, including patients with lumbar spinal stenosis (LSS) and lumbar intervertebral disc degeneration (LIDD) were recruited in this study. The spatio-temporal angular parameters associated with the CoP of the subjects during their gait were collected and examined. The measurements were used to calculate the CoP angle and symmetry angle (SA). Then the butterfly diagram (BD) intersection angle was introduced as a new potential parameter in gait assessment.
Results: The results of the current study showed that CoPs and SAs did not vary between the two groups (P > 0.05). The BD intersection angle, however, indicated some variations between patients with LSS and LIDD (P < 0.05).
Conclusion: While the results showed that CoP angles and SAs did not differ between the LSS and LIDD groups, it is hypothesized that such disorders that affect the gait could be reflected in the BD intersection angle. Therefore, the BD intersection angle is suggested as a clinical indicator in clarifying patients with lumbar spinal disorders.
Problematic aspects of the defender’s participation in the process of proving criminal cases against minors
Authors:   LL.D., professor, head of the department of criminal procedure of the Saint-Petersburg university of the MIA of Russia, E.K. Kutuev
Published: August 2021

The article deals with the most problematic aspects of the participation of a lawyer-defender in the process of criminal proceedings on a crime committed by a minor. The author emphasizes the specifics of the preliminary investigation and consideration of criminal cases in the courts in relation to juvenile accused and suspects. An in-depth analysis of the conceptual differences in the position of the defender as a procedural figure in Russian and Swiss legislation is carried out. Attention is focused on the need for further research to optimize the participation of a defense lawyer. Special attention is paid to the problem of gender consideration when choosing such an important procedural figure in cases of crimes committed by minors as a lawyer.
On the issue of countering illegal migration
Authors:   candidate of pedagogical sciences, acting head of the department of administrative law and administrative activity of the Stavropol branch of the Krasnodar university of the MIA of Russia, Kocherov Y.N. , Efimov A.A. ,   candidate of pedagogical sciences, senior lecturer of the department of administrative law and administrative activity of the Stavropol branch of the Krasnodar university of the MIA of Russia, Trusov A.I. ,   PhD (law), senior lecturer of the department of administrative law and administrative activity of the Stavropol branch of the Krasnodar university of the MIA of Russia
Published: August 2021

Based on a general theoretical analysis of the current legislation, this article discusses the problems of administrative regulation of illegal migration and reveals measures aimed at combating it, which are a combination of improving legislation in the field of migration, preventive and enforcement measures. In addition, the article presents statistical data on migration processes, identifies a number of topical areas for improving the fight against illegal migration in order to ensure national security.
Relevant Issues of Corruption Combating
Authors:   Leading Research Scientist of the Department of Criminal and Criminal Procedure Legislation, Fedorov Aleksandr V. ,   Judicial Administration of the Institute of Legislation and Comparative Law under the Government of the Russian Federation Honored Lawyer of the Russian Federation PhD (Law), Professor
Published: August 2021

The article is devoted to challenging aspects of modern corruption combating and the evaluation of the efficiency of Russian laws securing due combating of corruption of legal entities.
Minione krajobrazy Zatoki Puckiej
Authors: Andrulewicz Eugeniusz
Published: August 2021

Na podstawie opracowań i publikacji naukowych oraz wspomnień starszych rybaków i mieszkańców rejonu Zatoki Puckiej opisano stan Zatoki z lat 50. i 60. XX w. Przeanalizowano przyczyny degradacji Zatoki, w tym wskazano na konkretne przedsięwzięcia oraz decyzje gospodarcze, które doprowadzały do niekorzystnych zmian przyrodniczych. Omówiono działania podjęte na rzecz ochrony tego akwenu, które polegały głównie na uporządkowaniu gospodarki ściekowej w obrębie zlewiska. Wskazano, że Zatoka Pucka nadal jest nadmiernie obciążona dopływem związków odżywczych, a także eksploatacją turystyczną. Rośnie presja deweloperów i prowadzone są modernizacje portów rybackich, wskutek czego w rejonie Zatoki Puckiej wciąż zachodzą niekorzystne zmiany krajobrazowe.
​Priortization Strategies for the Resources of Traditional Paddy-cum-fish Culture in Lower Subansiri District
Authors: Yani Pani , Sharma Amod
Published: August 2021

Background: The practice of rice-cum-fish is extensively practice by Apatani tribe living in Lower Subansiri district of Arunachal Pradesh. The current study aimed to access the inputs impact on output, a resource-use-efficiency model on traditional paddy-cum-fish culture has been fitted. Methods: The present research investigation was carried out during the agricultural year 2014-15 with a total of 70 numbers of paddy-cum-fish respondents were selected by following a multi-stage simple random quota sampling technique. Result: Study reveals that the majority of the farmer’s were dependent upon agriculture and traditional paddy-cum-fish culture, the total cost of cultivation of traditional paddy-cum-fish culture was ₹ 28,782.70 per ha with average yield of 2.76 q per ha. The constraints faced by the traditional paddy-cum-fish farmers during production and marketing viz: poor marketing channel, price fluctuation and exploitation of farmers by intermediaries thereby farmer receives less profit etc.
Serotonin Transporter Gene Polymorphism in Patients with Schizophrenic Disorders
Authors: ÇOKER Fatma , DOGAN Orhan
Published: August 2021

Objective: Studies performed to solve the genetic basis of schizophrenia have focused on the role of serotonin in the etiology of schizophrenia and the function of serotonin transporter gene. This study aimed to investigate whether there was a relationship between schizophrenia and polymorphism of the Variable Number of Tandem Repeats (VTNR) and 5-HTT Gene-Linked Polymorphic Region (5-HTTLPR) variants in the transcriptional control region of the serotonin transporter gene or not.Method: A total of 55 schizophrenia patients who were diagnosed according to the diagnostic criteria of DSM-IV-TR and 32 healthy volunteers (the control group) were included in the study. DNAs were extracted from the bloods collected from the patient and control groups with the salting-out method. Alleles of the serotonin transporter gene polymorphism were determined with the polymerase chain reaction (PCR) method.Results: Based on the serotonin transporter gene intron 2 VNTR polymorphism, the distribution of 12/12, 12/10, 10/10, and 12/9 genotypes was 47.3%, 47.3%, 3.6%, and 1.8% in the patients and 46.9%, 46.9% and 6.3% respectively in the control group. There was no 12/9 genotype in the control group. The distribution of L/L, L/S and S/S genotypes according to the 5-HTTLPR polymorphism was 30.9%, 41.8% and 27.3% in the patients and 28.1%, 50.0% and 21.9% respectively in the control group. Conclusion: Although the allele and genotype distributions of the serotonin transporter gene polymorphism relatively differed between the patient and control groups this difference was not statistically significant.
Family Physicians’ Work Load, Personal Protection and Isolation Behaviors in COVID-19 Pandemic
Authors: GAMSIZKAN Zerrin
Published: August 2021

Objective: COVID-19 pandemic, which has been affecting the world for months, has affected health workers both in terms of working conditions and personal lifestyle. The aim of this study is to identify the changing workload of family physicians actively working in our country and to determine the factors affecting social protection behaviors.Methods: Between March 2020 and April 2020, a survey of 20 questions was conducted for family physicians via google forms.Results: Data of 392 Physicians, 52.8% (n = 207) female and 47.2% (n = 185) male, were included in the study. While 33.4% (n = 131) stated that they lived in the same house but in a different room with their families, 48.2% (n = 189) stated that they applied social distance by staying at least one meter away from their families. If physicians had children, they applied social isolation significantly more (p<0.001). Having relatives with a chronic illness at home also resulted in a significant increase in social isolation (p<0.001). Family physicians stated that they spend an average of 1.8 (Min1-Max 3) hours per day for the purpose of guiding patients both at home and for other needs.Conclusions: Primary care medicine has adapted to the situation by taking protective measures quickly in this pandemic, which has shaken the World. Family Physicians, whose most important task is preventive health service, performed their tasks in the follow-up and implementation of quarantine and home monitoring, even though they were sometimes away from their families.
Adénomatose pulmonaire chez un ovin en Libye : description macroscopique et histopathologique
Authors: Ali O.A. , Abdelsalam E.B.
Published: August 2021

Les caractéristiques générales et histopathologiques de l'adénomatose pulmonaire ovine (SPA) ont été mises en évidence dans le poumon droit d'une brebis âgée de race Beriberi, qui souffrait de détresse respiratoire persistante. Ces caractéristiques étaient principalement la prolifération papillomateuse multifocale de l'épithélium alvéolaire, avec d'abondantes infiltrations de macrophages alvéolaires. Quatre cas semblables ont été identifiés à partir du matériel obtenu pendant dix années d'études histopathologiques sur la maladie dans la région de Tripoli.
Etude préliminaire des helminthes du tube digestif du poulet en Somalie
Authors: Terregino C. , Catelli E. , Poglayen G. , Tonelli A. , Gadale O.I.
Published: August 2021

Une étude épidémiologique sur les helminthes du tube digestif du poulet (Gallus gallus domesticus) a été effectuée en Somalie. Cent quarante poulets de race locale et originaires de deux systèmes d’élevage différents ont été utilisés. Parmi eux, 125 provenaient d’élevages traditionnels et avaient été amenés à l’abattoir de Mogadishu et les 15 autres étaient issus d’un élevage intensif. Sur les 140 poulets examinés, 110 étaient infestés (79 p. 100) : 104 provenaient des élevages traditionnels et 6 de l’élevage intensif. Ainsi, 83 p. 100 des poulets du premier groupe et 40 p. 100 du second étaient infestés. Les résultats ont également mis en évidence une différence significative (p < 0,01) entre les deux types d’élevages concernant la prévalence des endoparasites. Les espèces parasitaires identifiées étaient les suivantes : Ascaridia galli, Subulura suctoria, Raillietina (Raillietina) tetragona, Raillietina (Raillietina) echinobothrida, Raillietina (Skrjabinia) cesticillus, Raillietina (Paroniella)  sp., Raillietina (Raillietina) sp., Raillietina sp., Cotugnia sp. et Mediorhynchus gallinarum. Aucun trématode n’a été trouvé. Les parasites ont présenté des formes d’associations diverses.
Prévalence de Rhinoestrus usbekistanicus (Gan 1947) chez l'âne (Equus asinus) dans la région de Niamey, Niger
Authors: Tibayrenc Robert , Garba D. , Dorchies Philippe
Published: August 2021

Rhinoestrus usbekistanicus (Gan 1947), recherché de janvier à décembre 1996 sur 234 têtes d’ânes (Equus asinus), a été mis en évidence pour la première fois au Niger. Le pic annuel d’infestation s’est situé essentiellement en novembre, avec une densité maximale de 8,9 larves par animal infesté. Aucune larve n’ayant été décelée de février à octobre, il est probable que l’adaptation du parasite à la sécheresse se fait par une durée de pupaison  prolongée dans le sol. Les parasites adultes ont semblé être en activité de  septembre ou d’octobre à novembre puisque à cette période des larves des trois stades ont été trouvées dans les têtes. Ils ont disparu en décembre, période à partir de laquelle seules des L3 ont été rencontrées.
Performances de veaux croisés taurins x zébus Gudali allaités artificiellement dans la zone tropicale montagneuse du Cameroun
Authors: Tawah C.L. , Mbah D.A. , Enoh M.B. , Messiné O.
Published: August 2021

Les effets du génotype et du sexe du veau, de l’année de naissance, de l’âge de la vache au vêlage, de l’âge du veau au sevrage et de la date de naissance du veau sur le poids à la naissance, le gain moyen quotidien avant sevrage, le poids au sevrage et le poids au sevrage ajusté ont été étudiés. Ces données ont été obtenues à partir de veaux aux trois-quarts-de-sang Montbéliard (M3G1) et aux trois-quarts-de-sang Holstein (H3G1) dans la zone tropicale montagneuse du Cameroun. Les effets du génotype du veau, de l’année de naissance et de l’âge de la vache au sevrage ont eu une influence significative sur les caractères de croissance et le poids au sevrage. Les veaux H3G1 ont été significativement plus lourds de 10% que les veaux M3G1 au sevrage. Comme prévu, les veaux mâles avaient tendance à être plus lourds à la naissance et au sevrage que les femelles du même âge. Toutefois, ces différences n’étaient pas statistiquement significatives. Par ailleurs, cette étude suggère que la génétique (génotype) et la gestion (âge de la mère et année de naissance du veau) devraient être prises en compte conjointement afin d’optimiser la croissance des bovins laitiers issus de croisements dans cet environnement.