bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of hepatitis B hyperimmunglobulin and vaccine in preventing perinatal transmission in children born from a mother with chronic B hepatitis
Authors: Kahveci Feyza Gökben , Civan Hasret Ayyildiz , Salihoğlu Özgül
Published: June 2021

Background. Viral hepatitis is still one of the important health problems all over the world today. Hepatitis B is a life-threatening liver infection that can cause chronic infections. It increases the risk of death from cirrhosis and hepatocellular carcinoma. One of the most important factors in chronic or acute hepatitis B infection is the age of infection. The earlier the virus is encountered, the greater the risk of chronicity of the disease. Prevention of perinatal transmission of the disease is of great importance. The most effective way to control hepatitis B infection is to prevent contamination and ensure immunity. There is a safe and effective vaccine available that provides 98–100% protection against hepatitis B. Prevention of hepatitis B infection control the development of complications, including chronic disease and liver cancer. The purpose of this study is to evaluate the efficacy of the vaccine and hepatitis immunoglobulin administered to prevent perinatal hepatitis B infection transmission in babies born to mothers with chronic hepatitis B infection. Materials and methods. Fifty-five children born to mothers with chronic hepatitis B infection in our hospital between January 1, 2013 and January 1, 2019 and accepted to participate in the study were included in our study. In retrospective file examination, maternal gestational age, maternal hepatitis B test, delivery method, baby birth weight, baby birth week, whether immunoglobulin and hepatitis B vaccine were administered to these babies in the first 24 hours after birth, hepatitis B vaccine and immunoglobulin administration time, bathroom status, infant hepatitis B tests, additional studies on the child’s viral diseases (hepatitis C, human immunodeficiency virus) and the baby’s liver transaminase tests (aspartate aminotransferase, alanine aminotransferase) were evaluated. The vaccination program of the baby, the control of the mother’s hepatitis B status, the time of the breast milk intake, the height and weight of the baby, the follow-up of the mother during pregnancy and the drug use status were collected. Children previously diagnosed with chronic B hepatitis were excluded from the study. Results. Hepatitis B surface antigen tests were positive in two infants who received three doses of hepatitis B vaccine. The mothers of both of these babies were positive for hepatitis B surface antigen and hepatitis B envelope antigen. Forty-three (78.2 %) patients had a protective antibodies to hepatitis B surface antigen, while 12 (21.8 %) didn’t have it. Conclusions. Hepatitis B serology should be checked in women who live in countries with high risk of chronic hepatitis B infection and who are pregnant, and babies born to these mothers should have hepatitis B vaccine and immunoglobulin.
COVID-19 pandemic in children of Сhernivtsi region: clinical features and annual treatment experience
Authors: Кoloskova O.K. , Bilous T.M. , Gopko N.V. , Myroniuk M.B.
Published: June 2021

Background. The pandemic of coronavirus disease (COVID-19) has been going on for more than a year and is a problem for the health care system worldwide. At the same time, there are few studies on the peculiarities of COVID-19 in children, in particular how clinical symptoms have changed during the year with the change of types of coronavirus SARS-CoV-2. Objective was to conduct a retrospective generalized analysis of the clinical course, laboratory markers and features of treatment in pediatric cases of COVID-19 in Chernivtsi region. Materials and methods. Using the retrospective cohort method, 263 clinical cases of COVID-19 in children of the Chernivtsi region hospitalized for the period of March 2020 — March 2021 were analyzed. Results. In this work, a dynamic analysis was performed of the clinical features of COVID-19 course in the population of children of Chernivtsi region, who were hospitalized during March 2020 — March 2021 at inpatient departments with signs of infection caused by SARS-CoV-2. The first group included 65 patients who were treated in the second quarter of 2020, the second group consisted of 90 children who underwent inpatient treatment in the third quarter of 2020, the third group included 87 children who were treated in the fourth quarter of 2020, and the fourth group consisted of 21 children who underwent inpatient treatment in the first quarter of 2021. It was found that the frequency of complaints of malaise was due to infectious-inflammatory, intoxication and catarrhal symptom complexes, although in contrast to the onset of the pandemic, the complaints and signs of intoxication and asthenic syndromes, infectious-inflammatory syndromes, nonspecific neurological symptoms increased with a relatively stable rate of lesions of the upper respiratory tract. In the first quarter of 2021, there was an increase in cases of multisystem inflammatory syndrome (odds ratio = 6.5) and community-acquired pneumonia (odds ratio = 2.7). Conclusions. A dynamic analysis of the course of COVID-19 in children has demonstrated phenotypic deviations of the disease with torpidity to the prescribed treatment for nonspecific symptoms of disorders of the nervous system and gastrointestinal tract with a decrease in duration and severity of fever, increased incidence of pneumonia (odds ratio = 2.7) and multisystem inflammatory syndrome (odds ratio = 6.5).
Assessment of the trophological status of children with rheumatic diseases
Authors: Omelchenko L.I. , Mukvich O.M. , Belskaya E.A. , Dudka I.V. , Ludvik T.A.
Published: June 2021

Background. Analyzing modern medical literature, it can be noted that in pediatric rheumatology, insufficient attention is paid to assessing the trophological status of sick children. Purpose: to investigate the nutritional status of children with various nosological forms of rheumatic diseases (RD). Materials and methods. The nutritional status of 35 children with RD was investigated, of which 5 patients had systemic variant of juvenile idiopathic arthritis (JIA), 13 patients had articular form of JIA, 4 patients had systemic lupus erythematosus, 3 patients had mixed connective tissue disease (Sharp’s syndrome), 6 children had juvenile systemic scleroderma, 4 patients had juvenile dermatomyositis. All patients underwent a generally accepted comprehensive clinical, laboratory and instrumental examination. To assess the trophological status, the body mass index and the blood serum leptin were determined by the enzyme immunoassay and the trophological status coefficient was calculated. Results. The results of the conducted studies indicate that trophological insufficiency of varying degrees manifested in 78.5 % of children with RD in a decrease in body weight, depletion of muscle mass, adipose tissue, changes in the skin and its appendages, mucous membranes, organs of vision, oral cavity, cardiovascular system. The most pronounced trophological insufficiency was found in children with systemic JIA, with juvenile scleroderma and dermatomyositis.
Are metabolic syndrome and its components a risk factor for gallbladder polyps?
Authors: Duygu Boz Emine , Demirtunç Refik , Sözen Mehmet
Published: June 2021

Background. Gallbladder polyps are usually benign lesions originating from the mucosa and are usually detected incidentally during radiological examinations or after cholecystectomy. Gallbladder polyps are common and may have malignant risk. In this study, it was investigated whether metabolic syndrome (MS) is a risk factor for gallbladder polyps. This study aimed to determine the prevalence of MS and its components in patients with gallbladder polyps. Materials and methods. We conducted a retrospective, cross-sectional study. We investigated the age, gender and past medical history of 90 adults (45 with polyps, 45 without polyps). Body height and weight, body mass index, waist circumference and laboratory data were obtained from the hospital data processing system. National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and International Diabetes Foundation (IDF) MS diagnostic criterion were used for the diagnosis of MS. Results. 51.1% (n=46) of the subjects participating in the study were female and 48.8% (n=44) were male. The mean age was 58.79±15.70 years. MS was found in 56.7% (n=51) of the cases according to the criteria of NCEP-ATP III and, in 64.4% (n=58) of the cases according to the IDF criteria. In patients with a gallbladder polyp, MS was detected in 55.55% according to the criteria of NCEP-ATP III and in 66.66% according to the IDF criteria. The rates of MS were not similar in the gallbladder polyp group and control group (p>0.01). Abdominal obesity was found to be a risk factor for the development of gallbladder polyp (odds ratio: 14.23, 95% CI: 1.751–15.722; p<0.01). Although it was not statistically significant, low HDL and hypertension were detected approximately 2 times higher in patients with gallbladder polyps than in the control group. Conclusions. While MS is not associated with the development of gallbladder polyp, obesity is seen as a sole risk factor.
Pleiotropic effects of ursodeoxycholic acid
Authors: Stepanov Yu.М. , Salenko А.V.
Published: June 2021

The article summarizes the literature data on the expansion of the range of application of ursodeoxycholic acid due to its various mechanisms of action. Almost 50-year history of the study of its properties has proven choleretic, litholytic, antiapoptotic, anti-inflammatory, immunomodulatory, cytoprotective, antifibrotic and hypocholesterolemic effects. In addition to the well-known functions of bile acids, their role has been shown as signaling, endocrine molecules that regulate glucose, lipids, and energy metabolism through pathways mediated by the activation of the nuclear receptor of the farnesoid X receptor and the cell surface G protein-coupled receptor, TGR5. The variety of nosological forms in which this substance can be successfully used is substantiated.
Los indígenas de la isla Nutka, los otomís, los antiguos mexicanos y las ruinas de San Juan de los Llanos (hoy Cantona) en la Gazeta de Literatura de 1790
Authors: Medina-González José Humberto
Published: June 2021

The erudite scholar and editor Antonio Alzate y Ramírez published in his La Gazeta de Literatura (8 February 1790, capital of New Spain) his first study about the cultural connections he discovered between the natives of Nootka Archipielago (today West Canada), the ancient Mexicans, the Otomis and the distant place of their origin. Alzate added to this publication a complete transcription of an early report written by Licenciado Ruiz Cañete in 1786 of an ancient settlement in San Juan de los Llanos, which ruins are located in the State of Puebla, today known as Cantona (probably the earliest documental record of this archaeological zone). A few years later Luxembourgian traveller and archaeologist Guillermo Dupaix visited this site after reading Alzate’s text which was considered lost by some archaeologists for several decades in the 20th century or doubted about its existence. An appendix to this article includes a complete transcription of the report on the ruins of San Juan de Los Llanos, published by Alzate in this Gazeta, Why did Alzate publish this text at this particular date in his Gazeta?
Las endechas judeoespañolas del norte de Marruecos: un análisis semiótico
Authors: Rosas-Mayén Norma
Published: June 2021

The aim of this study is to offer a semiotic analysis of the dirges (songs of the dead) that were transmitted orally and intergenerationally among the Sephardic Jewish communities that settled in northern Morocco after their expulsion from Spain in 1492. The method used in the present work is documental and is based on the compilation of dirges made by Manuel Alvar (1969) in the Judeo-Spanish communities of this region in the second half of the 20th century. This study comes to the conclusion that the semiotic content of these texts is significant, because it sheds light on medieval Judeo-Spanish mortuary customs and beliefs, as well as the role that Jewish Sephardic women played as agents of transmission of a lugubrious poetics in the Haketian language, nowadays extinct.
Hacia una descolonización de la Biodiversity Heritage Library
Authors: Ponce-de la Vega Lidia
Published: June 2021

This critique introduces the PhD thesis “Virtual Biodiversities and Digital Knowledges”, a critical study of the digital library Biodiversity Heritage Library (BHL) which seeks to understand the epistemic construction in the matter of Latin American biodiversity in order to advance the digital decolonization agenda and promote an ethical approach to the narratives of the region and its human and non-human inhabitants.
eLaboraHD: un proyecto pedagógico en humanidades digitales
Authors: Priani-Saisó Ernesto
Published: June 2021

eLaboraHD is a digital pedagogy project stemmed from the need to teach higher-level students the use and application of digital tools. On that basis, the project has grown to give workshops to teachers and involve those who make digital tools and projects oriented towards teaching in the promotion of adoption of these tools.
Bacterias y hongos endófitos de la familia Cactaceae y sus aplicaciones
Authors: Rodríguez-Mendoza Clara Angélica , Hernández Luis Ricardo , Pérez-Armendáriz Beatriz , Juárez Zaida Nelly
Published: June 2021

Las especies de la familia Cactaceae habitan en zonas con altas temperaturas, escasez de agua y suelos con déficit de nutrimentos. Esto es el resultado de procesos complejos como adaptaciones fisiológicas y físicas, además de la coevolución con microorganismos endófitos que habitan en los tejidos vegetales con relevante importancia para las plantas, porfacilitar su establecimiento en estratos rocosos, ayudar a la fijación de nitrógeno atmosférico y fósforo a través de bacterias, así como una acción antimicrobiana por parte de los hongos. Los estudios sobre bioprospección de endófitos en las cactáceas aún son escasos, por lo que este trabajo compila la literatura científica sobre bacterias y hongos endófitos en cactus disponible en las bases de datos Dialnet, DOAJ, EBSCO, Google académico, iSEEK, Redalyc, REDIB, Science Direct, SciFinder, SciELO, Springer, Web of Science y Wiley Online Library. La revisión dio como resultado 22 trabajos publicados en un periodo de 33 años, de los que solamente el 36% analiza su bioactividad. Se destaca el uso de los endófitos en la biotecnología, principalmente para beneficio social (fines agrícolas y médicos), así como de conservación.
El receptor S1P1 de la esfingosina1-fosfato: avances en el conocimiento de su estructura, función e importancia biomédica
Authors: Martínez-Morales Juan Carlos , García-Sáinz J. Adolfo , Romero-Ávila M. Teresa
Published: June 2021

La esfingosina1-fosfato (S1P) es un metabolito intermediario en el catabolismo de la esfingomielina y un “lípido bioactivo”, con la capacidad de funcionar como hormona local al modular las funciones de distintas células y tejidos; en las células regula una gran variedad de respuestas, como la migración, la diferenciación y la sobrevivencia y en los tejidos la angiogénesis, la cardiogénesis, el desarrollo de las extremidades, la formación del sistema linfático y nervioso, entre otros procesos. El receptor S1P1 es un miembro de la familia de receptores acoplados a proteínas G que media muchas de las acciones de la S1P. Este receptor tiene una gran importancia médica por estar involucrado en la patogenia de la esclerosis múltiple. En condiciones fisiológicas el receptor S1P1 se expresa en la superficie de los linfocitos y regula la salida de esas células de los ganglios linfáticos por quimiotaxis. Por otra parte, la esclerosis múltiple es una enfermedad crónica, autoinmune y neurodegenerativa del sistema nervioso central, asociada en muchos casos con una progresión irreversible que conduce a la discapacidad. En la patogenia de esta enfermedad, después de que los linfocitos salen de los ganglios linfáticos, se encuentran en el torrente sanguíneo y atraviesan la barrera hematoencefálica invaden el sistema nervioso central, favorecen la secreción de citocinas inflamatorias que activan a los macrófagos y a otras células, destruyendo las vainas de mielina; además, los linfocitos B producen anticuerpos contra los componentes de la mielina incrementando la desmielinización, el daño axonal y neuronal que caracterizan a los pacientes con esclerosis múltiple.
Journey of Limonene as an Antimicrobial Agent
Authors: Gupta Akshi , Jeyakumar Ebenezer , Lawrence Rubina
Published: June 2021

Injudicious consumption of antibiotics in the past few decades has arisen the problem of resistance in pathogenic organisms against most antibiotics and antimicrobial agents. Scenarios of treatment failure are becoming more common in hospitals. This situation demands the frequent need for new antimicrobial compounds which may have other mechanisms of action from those which are in current use. Limonene can be utilized as one of the solutions to the problem of antimicrobial resistance. Limonene is a naturally occurring monoterpene with a lemon-like odor, which mainly present in the peels of citrus plants like lemon, orange, grapefruit, etc. The study aimed to enlighten the antimicrobial properties of limonene as per previous literature. Advantageous contributions have been made by various research groups in the study of the antimicrobial properties of limonene. Previous studies have shown that limonene not only inhibits disease-causing pathogenic microbes, however, it also protects various food products from potential contaminants. This review article contains information about the effectiveness of limonene as an antimicrobial agent. Apart from antimicrobial property, some other uses of limonene are also discussed such as its role as fragrance and flavor additive, as in the formation of nonalcoholic beverages, as solvent and cleaner in the petroleum industry, and as a pesticide. Antibacterial, antifungal, antiviral, and anti-biofilm properties of limonene may help it to be used in the future as a potential antimicrobial agent with minimal adverse effects. Some of the recent studies also showed the action of limonene against COVID-19 (Coronavirus). However, additional studies are requisite to scrutinize the possible mechanism of antimicrobial action of limonene.
Metagenomic Exploration of Bacterial Community Structure of Earthworms’ Gut
Authors: Thakur Samrendra Singh , Lone Azhar Rashid , Tiwari Nalini , Jain Subodh Kumar , Yadav Shweta
Published: June 2021

Living organisms are naturally bestowed with unique and imitable qualities for maintaining ecological balance and earthworms are no exceptions. These so-called keystone species of terrestrial ecosystems are equipped with wonderful machinery, allowing them to nurture soil beautifully. Earthworm gut represents a potential microbial reservoir, having a complex interdependence with the host. The study aimed to profile bacterial community structure of three earthworm species belonging to two different life forms; Perionyx excavatus and Eudrilus eugeniae (epigeic), Polypheretima elongata (endogeic) respectively. Diversity analysis using 16S amplicon sequencing revealed that the dominant phyla were Proteobacteria (34.17-77.88) followed by Actinobacteria (13.43-35.54%), Firmicutes (1.69-15.45%) and Bacteroidetes (0.51-8.12%). The alpha diversity indices explicit similar gut microbiota of Perionyx excavatus and Eudrilus eugeniae and while higher alpha diversity was recorded in comparison to Polypheretima elongata gut. The taxonomic to the phenotypic annotation of 16S rRNA metagenomes revealed that dominance of Gram-negative bacterial community in all earthworm species while, Polypheretima elongata comprises higher percentage (78%) of Gram-negative bacterial community to Perionyx excavatus (32.3%) and Eudrilus eugeniae (38.3%). The oxygen requirement phenotypic analysis showed that all earthworm species were abundant with aerobic followed by anaerobic bacterial groups. Furthermore, functional metabolism phenotypic analysis revealed that a high abundance of ammonia oxidizers (29.3-80.2%), the gut microbiomes showed the relative abundance of sulphate reducer (22.6-78.7%), nitrite reducer (19.8-73.2%), dehalogenators (12.6-25.1%), illustrating in the role of these microbial communities in various degradation and bioremediation processes. The present study signifies the intrinsic gut microbiota of earthworm species for intensified biodegradation.
Dynamics of labor migration in the Republic of Bashkortostan
Authors: Akhmetova G. F.
Published: June 2021

The article considers some indicators of the widespread social phenomenon in Russia - labor migration, which, according to the data for 2019, involves about 2.9 million Russians, or 4% of the employed population. These are internal labor migrants who temporarily work outside their regions. This type of labor migration of Russians has common features with temporary employment in the United States, Canada, and Australia (long distance commuting - LDC), fly-in/fly-out - FIFO). The empirical basis of the article consists of the statistical data (results of the labor force survey by the Federal State Statistics Service for 2011-2019) and the results of sociological research conducted in the region with a high level of shift employment - the Republic of Bashkortostan - in 2015-2019. The statistical data prove regional differences in the Russian shift employment: the majority (72%) of internal labor migrants live in a third of the regions with high and medium levels of temporary labor migration; in some regions, the level of temporary labor migration decreases. The sociological data show different involvement in shift employment depending on place of residence, gender and age, marital status and level of education. The same social-territorial and social-demographic features are evident at the national level. At the federal level, internal labor migration, as a tool for social-economic development, helps to solve the problem of labor shortage in certain areas and sectors of economy; therefore, such labor migration is supported by legal acts. At the regional level, it decreases the labor and demographic potential of the regions that provide labor migrants. To preserve the economic and demographic potential and to strengthen the competitiveness of such regions, we need to develop regional labor markets and labor mobility within regions.
Online communities in the study of political communication
Authors: Platonov K. A. , Legostaeva N. I.
Published: June 2021

Online communities in the study of political communication are a relatively new research field. Within its framework, independent thematic sections are developing, which in many respects remain fragmented due to the insufficient systematization. The article presents the results of the analysis and description of the research field of online communities in the context of political communication based on 60 English-language sources. This sample included publications on a wide range of issues: from the activity of official accounts and websites of politicians, parties, organizations to the user behavior and political discussions in virtual communities. The authors identified five large thematic groups that consider online communities in different research perspectives: classification of communities, study of their structure and elements, analysis of their strategies and tactics, functions and effects, and life cycles. The article describes the main features and internal structure of the identified thematic groups, considers approaches and methods for solving specific tasks in the study of actors, channels, practices and models of political communication. The authors also consider the technical factors of the formation of communities, differences in methods and units of analysis, types of political communicants. The authors make a conclusion about the sufficient maturity of the research field and its thematic sections, which is combined with the differing popularity of research topics. Online communities represent a special public space which allows researchers to answer questions about the success of political leaders, movements and organizations, the effects of the viral spread of online protests and flash mobs, and the audiences response to significant politicized issues. The authors identify two trends in the development of the corresponding methodology: strengthening practical orientation and increasingly complex techniques based on the machine algorithms for data analysis.
Processo criativo em moda: redes de colaboração entre microempreendedores individuais gaúchos
Authors: Pinheiro Cristiano Max Pereira , Schmidt Serje , Schreiber Dusan , Cherutti Milena
Published: June 2021

A competitividade de mercado ressalta a importância em estreitar laços entre empresas parceiras, de forma que, quanto mais fortes os vínculos organizacionais de troca, maiores as implicações de lucratividade bilateral, servindo, também, como fonte de vantagem competitiva. Este estudo admite como temática as estratégias de redes de colaboração e a sua influência no processo criativo no âmbito da moda. Enquanto problema de pesquisa, tem-se como a colaboração afeta o processo criativo de microempreendedores individuais da moda gaúcha? De forma a responder a essa questão, propõe-se duas hipóteses, a) através da troca de experiências e parcerias entre microempreendedores individuais do mesmo segmento, visando o crescimento mútuo em estratégias complementares, como participação em feiras e eventos de moda, colaboração de processos, entre outros ou; b) a partir da estratégia de cocriação, com participação direta do público-alvo, clientes e consumidores da marca auxiliando no processo de criação de novos produtos, visando maior assertividade. No que diz respeito ao objetivo geral deste trabalho, consiste em compreender como as redes de colaboração afetam o processo criativo em MEIs no âmbito da moda. Como método, os autores optaram por uma pesquisa aplicada, por meio de uma pesquisa de campo, realizando uma entrevista com um microempreendedor de moda, para obter dados empíricos e, também, documental, para assim, responder ao problema do estudo. A partir desta entrevista, pôde-se perceber que as redes de colaboração são importantes para microempreendedores por meio da realização de parcerias que auxiliam, principalmente, na divulgação das marcas para que, assim, cresçam juntas.
O que faz uma cidade ser criativa? Uma análise a partir das dimensões conceituais
Authors: Neves Brenda Stefanny Batista , Cumarú Wandeline de Araujo , Morais Hannah Miranda
Published: June 2021

O que é uma cidade criativa? Quais são seus traços principais? Diante desses questionamentos, o presente artigo visa analisar, por meio de uma revisão sistematizada de literatura, as dimensões conceituais que definem uma cidade criativa, mensuradas pela literatura acadêmica brasileira dos últimos 10 anos. A coleta de dados ocorreu em 04 bancos de dados, registrando 26 estudos analisados. Os critérios metodológicos da revisão sistematizada optaram por analisar estudos empíricos, que apresente um caráter qualitativo e metodologias similares estabelecidos por 5 critérios de inclusão e 4 descritores de busca. Os achados de pesquisa apontam seis dimensões conceituais para mensurar uma cidade criativa, sendo elas; economia criativa, cultura/turismo, hibridismo cultural, mobilidade, design urbano e performance urbana. Considerações finais apontam que as dimensões conceituais discutidas são fortemente influenciadas pelo contexto das cidades brasileiras e das dinâmicas da nossa gestão pública.
Análise do setor cultural e criativo em Portugal: principais estudos macroeconômicos entre 2008-2018
Authors: Cortez Maria Raquel , Teixeira Luis
Published: June 2021

Em Portugal, datam do início deste milénio os primeiros estudos sobre o setor cultural e criativo e a sua projeção no desenvolvimento do país.Entre 2008 e 2018, vários estudos foram realizados para caracterizar o setor e permitir a implementação de medidas de apoio eficazes. Os diferentes estudos apontam para um contributo crescente do setor para a criação de emprego e de riqueza. Durante a crise económica que o país atravessou, os efeitos negativos verificados forem rapidamente ultrapassados, mostrando o seu dinamismo. A aposta numa formação tecnológica de qualidade e o aumento do turismo têm promovido parcerias e levado à implementação de novos modelos de negócio.Este artigo apresenta os principais estudos realizados em Portugal, destacando os seus objetivos, as metodologias seguidas e limitações, assim como os principais resultados e conclusões.
Storytelling - como contar histórias sobre marcas que não têm uma boa história para contar
Authors: Parente Umehara Lopes , Laus-Gomes Victor
Published: June 2021

Este artigo levanta a hipótese de que marcas que não têm suas origens alicerçadas por uma boa história, que lhes gere empatia e adicione componentes estratégicos de valor junto a seu público-alvo, podem ainda assim, fazer uso do Storytelling[1] como ferramenta em sua comunicação. Para sustentar essa proposição, é apresentado um estudo exploratório sobre casos de empresas notórias, as quais tiveram sua criação e crescimento galgado em estratégias empresariais, sem necessariamente conter componentes narrativos empáticos que suportassem a construção de boas histórias de origem, mesmo assim, adotam o Storytelling como parte de sua estratégia comunicacional.A hipótese também apresenta casos de marcas que dispõem de uma boa história de fundação em seu alicerce, e mesmo assim, desenvolvem novas narrativas como forma de manter a ligação experiencial com seus usuários ou clientes.Por fim, o artigo apresenta os recursos identificados na pesquisa como novo paradigma para a adoção do Storytelling na construção de campanhas e ações para a comunicação de marca.
A imagem da capa
Authors: Formiga Eliana de Lemos Formiga
Published: June 2021

CONSUMO E ENVELHECIMENTON16 V6
Editorial
Authors: Dubeux Veranise Jacubowski Correia
Published: June 2021

Editorial da Revista Diálogo com a Economia Criativa n16 v6
A velhice na propaganda e a ilusão referencial
Authors: Debert Guita Grin
Published: June 2021

palestra
Apresentação do Dossiê Consumo e Envelhecimento
Authors: Barbosa Lívia
Published: June 2021

não consta
Aplicativos colaborativos como reflexos da economia criativa e da cultura participativa
Authors: Fetzner Monica , Pinheiro Cristiano Max Pereira , Wissmann Débora
Published: June 2021

Este trabalho tem como tema a relação entre a economia criativa e a cultura participativa, buscando identificar quais de suas características convergem em aplicativos colaborativos. Tem o aplicativo Colab como objeto de estudo, uma ferramenta para incentivar o cidadão a fiscalizar os problemas da cidade, propor melhorias e avaliar espaços e serviços públicos. Por meio dos procedimentos de pesquisa documental, em uma perspectiva de visualizar o aplicativo como documento, e a pesquisa bibliográfica, que apresenta como principais autores Howkins (2013) e Jenkins (2009), este trabalho – essencialmente descritivo – identificou como principais características da economia criativa e da cultura participativa que convergem nos aplicativos colaborativos (a) o poder ao cidadão proporcionado pela tecnologia, (b) o estímulo ao desenvolvimento de novas ideias, (c) a circulação do conteúdo dependente da participação ativa dos consumidores, (d) a maneira de trabalhar em conjunto em um software para a solução de problemas da vida real e (e) o esforço concentrado realizado na colaboração.
Indeks Morfologi Tubuh Kambing Peranakan Etawah (PE) di Sentra Pembibitan Kambing Kecamatan Mestong Kabupaten Muaro Jambi
Authors: Wiyanto Eko , Putra Anto Yahya
Published: June 2021

Penelitian ini dilakukan di Sentra Peternakan Kambing di kecamatan Mestong kabupaten Muaro Jambi selama 6 (enam) bulan. Metode yang digunakan dalam penelitian ini adalah survai. Obyek yang diamati adalah kambing Peranakan Etawah umur lepas sapih (6 bulan). Penentuan sampel dilakukan dengan metode purposive sampling. Tujuan dari penelitian ini adalah mengetahui indeks morfologi ukuran-ukuran tubuh kambing Peranakan Etawah yang meliputi : weight, height slope, length index, width slope, depth index, foreleg length, balance dan cumulative index. Hasil penelitian menunjukkan bahwa rata-rata ukuran tubuh kambing jantan lebih besar dibandingkan dengan kambing betina. Dari perhitungan didapatkan nilai indeks morfologi kambing jantan adalah weight =  52726,34; Height slope = -1,88; Lenght index = 1,0165; Width slope = 0,9935; Depht index = 0,5003 dan Foreleg length = 27,24. Sedangkan indeks morfologi kambing betina adalah Weight =  47477,46; Height slope = -1,94; Lenght index = 1,0278; Width slope = 0,9645; Depht index = 0,4988 dan Foreleg lenght = 26,34. Kesimpulan dari penelitian ini adalah kambing Peranakan Etawah umur lepas sapih di Sentra Pembibitan Kambing di kecamatan Mestong kabupaten Muaro Jambi mempunyai indeks morfologi yang tidak berbeda jauh dengan kambing Peranakan Etawah yang ada di beberapa daerah di Indonesia.

kambing Peranakan Etawah, Indeks morfologi, umur lepas sapih.
ACE2 receptor, TRL-4 and SARS CoV-2: Do long acting opioids and opioid antagonists have potential for therapy?
Authors: Eagleton Marie , Stokes Siobhan , Fenton Fiona , Keenan Eamon
Published: June 2021

Despite the advent of a vaccine, broadening the arsenal of drugs
effective in the treatment and prevention of COVID-19 disease remains
critical in the global effort to control the SARSCoV2 pandemic. Opioids
and opioid antagonists may have a role in treating and in the prevention
of this disease based on a number of observations: an unexpectedly low
incidence of COVID-19 has been observed in patients treated for opioid
dependency with long acting opioid drugs such as methadone; opioids bind
to the ACE2 transmembrane protein, a molecule that is widely considered
to be main host cell receptor for SARS CoV2 cell entry; opioids have
systemic immunomodulatory effects which may influence the response to
the virus; studies aimed at repurposing drugs for treatment of COVID-19
have identified that opioids have therapeutic potential and finally
there are ongoing trials of some of these drugs. The interaction of long
acting opioids or opioid antagonists with the ACE2 receptor and the
possible effects on TLR4 function in SARS CoV2 infection should be given
serious consideration when developing effective therapies.

Note an updated version of this preprint is under review with the
British Journal of Anaesthesia
High-performance electret and antibacterial meltblown nonwovens doped with nanoparticles of boehmite and ZnO for air filtration
Authors: Han Mingchao , He Hongwei , Kong Weikang , Dong Kun , Wang Bangying , Yan Xu , Wang Liming , Ning Xin
Published: June 2021

The current pandemic caused by Covid-19 triggered intensively the
development of high-performance air filters. Polypropylene (PP) is
widely used as the raw material of meltblown nonwovens that is the core
layer in air filters, such as, masks. In this study, an electret PP
meltblown nonwoven with antibacterial activity was developed, and nano
boehmite (AlOOH) and nano-ZnO employed as electret and antibacterial
agent, respectively. 0.5-2.0 wt% of AlOOH and 1.0 wt% of ZnO were
doped into PP matrix using a twin-screw extruder and the resulting
masterbatches applied as raw materials to afford nonwovens via a
meltblown process. The as-prepared nonwovens were characterized by means
of SEM, IR and DSC/TG, and after corona charging, the filtration
efficiency, charge decay and antibacterial properties were evaluated.
More than 1.0 wt% dosage of AlOOH endowed the nonwoven with high
filtration efficiency and 1.0 wt% of ZnO brought about antibacterial
activity. Corona charging was an effective means to make the nonwovens
electret charged and the charges were quicker to decay in air than in a
sealed bag. The as-prepared meltblown nonwoven would be a remarkably
promising filter in air filtration.
Tendencias en los temas de los conceptos del Consejo Técnico de la Contaduría Pública como organismo normalizador técnico contable en Colombia
Authors: Munevar Moreno Rodolfo Antonio , Barón-Vivas Angie Viviana , Galindo-Rodríguez Yerly Andrea
Published: June 2021

Las fuentes de información documental que emiten organismos normalizadores como el Consejo Técnico de la Contaduría Pública (CTCP) son documentos que aportan la evolución y el desarrollo de una institución y ameritan la revisión desde varios enfoques en la investigación. Un ejemplo es los conceptos que se originan a partir de las consultas realizadas por personas naturales y jurídicas tanto del sector privado como del sector público. El artículo tiene como propósito establecer las tendencias de temas de los conceptos emitidos y publicados por parte del CTCP en el período comprendido entre el año 1992 y el año 2018. En este avance se revisó el contenido de 6578 conceptos de 7191 que están publicados en la página del CTCP, estableciendo categorías relacionadas con los elementos de los estados financieros, el tipo de persona que realiza la consulta y el sector al que pertenece, utilizando la frecuencia, herramienta de la estadística descriptiva en los valores encontrados de las categorías definidas.
 
Como conclusión principal, se encuentra un punto de inflexión en el año 2009, que refiere a un aumento de emisión y publicación de conceptos por parte del CTCP dado posiblemente por el cambio de modelo contable en Colombia para ese mismo año. La contribución del artículo es un avance y propuesta para trabajar con fuentes documentales emitidas por instituciones públicas de la profesión, para este caso, con un enfoque descriptivo, pero que pueda abarcarse desde otros enfoques y metodologías de investigación.
La creatividad y el emprendimiento como fundamento de la economía naranja en el análisis curricular del programa de Arquitectura de la Universidad La Gran Colombia
Authors: Alarcón-Leudo Germán Andrés , Jímenez-Londoño José
Published: June 2021

Problemática: teniendo en cuenta lo incontrovertible que resulta colocar la educación y la economía naranja como sectores complementarios, con la ley 30 o Ley de Educación Superior, ciertos componentes como la investigación y la extensión permiten aumentar la competitividad en función de la producción científica e investigativa al interior de las instituciones de educación superior. Objetivos: esta investigación busca analizar la aproximación existente entre creatividad y emprendimiento como ejes estructurantes y conceptuales de la economía naranja frente al actual currículo formativo que ofrece el programa de Arquitectura de la Universidad La Gran Colombia. Materiales y métodos: el análisis constituye un estudio de caso, de alcance cualitativo y de tipo descriptivo, mediante un rastreo bibliográfico a través de diferentes bases de datos y repositorios en diferentes medios documentales. Resultados: siendo la educación una “actividad naranja”, debería contar con mayor presupuesto, no como un gasto social, sino como inversión social, para el crecimiento económico. Discusión: es por ello por lo que surge la necesidad de ajustar el presupuesto nacional y las políticas públicas para el fortalecimiento de este sector en función de su crecimiento, mediante sus múltiples dimensiones y a través del ofrecimiento de productos y servicios culturales por la economía naranja. Conclusiones: en el desarrollo de la economía, deben establecerse objetivos claros y precisos, alineados con los objetivos del desarrollo sostenible y las industrias creativas, en función del fortalecimiento de la economía naranja, teniendo en cuenta la articulación existente entre las políticas públicas, la oferta de educativa y el mercado laboral. Contribución original: la inclusión de la creatividad y el emprendimiento como ejes estructurantes y conceptuales al actual currículo formativo del programa de Arquitectura de la Universidad La Gran Colombia es necesaria dentro del plan de desarrollo institucional y permite integrar lo público, lo privado y el sector académico
Pathogenic TP53 mutations influence chemotherapy response and survival rate of HPV-negative oral carcinomas
Authors: Jovic Sasa , Kozomara Ruzica , Stosic Srboljub , Jovandic Stevo , Zeljic Katarina , Supic Gordana
Published: June 2021

Background/Aim. Oral squamous cell carcinoma (OSCC) is the most common tumor type of head and neck carcinomas, characterized by a high recurrence rate and patients? poor survival. Further elucidation of the function and regulation of the TP53, a pivotal tumor suppressor gene, would provide advances in predicting the clinical behavior, prognosis, and chemotherapy response of OSCC patients. Thus, we investigated the association of TP53 gene mutations with survival and response to cisplatin chemotherapy in human papilloma virus (HPV)-negative OSCC patients. Methods. The potential clinical relevance of TP53 mutations was analyzed in 82 patients with HPV-negative OSCC. All patients underwent radiotherapy, and 25 patients received cisplatin chemotherapy. A negative HPV status was deter-mined by type-specific polymerase chain reaction (PCR) for high-risk HPV 16, 18, 31, and 33. Targeted sequencing of TP53 exons 4?8 was assessed by Sanger sequencing. Results. Of 82 HPV-negative OSCC patients, 49 (59.79%) had TP53 mutations, and 26 patients (31.7%) carried pathogenic TP53 mutations. Patients with pathogenic TP53 mutations had significantly reduced overall survival (p = 0.009). Recurrence status, but not TP53 mutations, was an independent marker of poor survival in our cohort [hazard ratio (HR) = 4.733, 95% confidence interval (95% CI): 2.027?11.053, p = 0.0001]. In the sub-cohort of patients who underwent cisplatin-based chemotherapy, pathogenic TP53 mutations were predictors of poor response to chemotherapy (p = 0.026). Conclusion. Our findings indicate that pathogenic TP53 mutations in HPV-negative OSCC tumors could be a prognostic marker of patients? reduced overall survival. In addition, pathogenic TP53 mutations in HPV-negative OSCC could be a marker of poor chemotherapy response of OSCC patients.
Allergic Rhinitis
Authors: Marcus Sonya
Published: June 2021

Allergic rhinitis is a common condition that affects 10-40% of adults in the United States annually. It has a significant impact on patient quality of life and poses a substantial economic burden on society. Knowledge regarding accurate diagnosis, testing and treatment options are important in the management of this prevalent condition. Treatment options include allergen avoidance, pharmacotherapy and allergy immunotherapy.
This review contains 7 figures, 6 tables and 28 references.
Key words: allergic rhinitis, rhinorrhea, nasal congestion, intranasal corticosteroids, antihistamines, skin prick allergy testing, intradermal allergy testing, subcutaneous immunotherapy, sublingual immunotherapy, anaphylaxis
STAT3 but Not ERK2 Is a Crucial Mediator Against Diet-Induced Obesity via VMH Neurons
Authors: Gonçalves Gabriel Henrique Marques , Tristão Sabrina Mara , Volpi Rafaella Eduarda , Almeida-Pereira Gislaine , Borges Beatriz de Carvalho , Donato José , Castro Margaret de , Antunes-Rodrigues José , Elias Lucila Leico Kagohara
Published: June 2021

Leptin plays an important role in the protection
against diet-induced obesity (DIO) by its actions in ventromedial hypothalamic
(VMH) neurons. However, little is known about the intracellular mechanisms
involved in these effects. To assess the role of the STAT3 and ERK2 signaling
in neurons that express the steroidogenic factor 1 (SF1) in the VMH on energy
homeostasis, we used cre-lox technology to generate male and female mice with specific disruption
of STAT3 or ERK2 in SF1 neurons of the VMH. We demonstrated that the
conditional knockout of STAT3 in SF1 neurons of the VMH did not affect body
weight, food intake, energy expenditure and glucose homeostasis in animals on
regular chow. However, when challenged with high-fat diet (HFD), loss of STAT3
in SF1 neurons caused a significant increase in body weight, food intake
and energy efficiency that was more remarkable in
females which also showed a decrease in energy expenditure. In contrast,
deletion of ERK2 in SF1 neurons of VMH did not have any impact on energy
homeostasis in both regular diet and HFD conditions. In conclusion, STAT3 but
not ERK2 signaling in SF1 neurons of VMH plays a crucial role to protect
against DIO in a sex-specific pattern.
A Corpus-based Study of the Impact of Directionality on English<>Chinese Simultaneous Interpreting
Authors:   , Zhai Xiaoyi
Published: June 2021

This PhD thesis investigates the impact of directionality on English<>Chinese simultaneous interpreting (SI) based on a purposely built spoken corpus. The study examines disfluencies (filled pauses and repetitions) and repairs from both quantitative and qualitative perspectives. An expert-novice paradigm is also adopted with the aim of determining if directionality influences these two different groups. The quantitative analyses look at the frequency of filled pauses and repetitions, as well as the frequency of different types of repairs (including appropriateness repairs, different repairs, error repairs, mid-articulatory repairs and repair failures) and the proportion of each category of disfluencies and repairs. The aims are to determine if directionality influences SI fluency and to provide a holistic view of the extent to which directionality influences the occurrence of disfluencies and repair behaviour. These quantitative analyses are complemented by qualitative analyses of filled pauses and repetitions, as well as each category of repairs. The aims are to examine the influence of directionality on the occurrence of filled pauses and repetitions and to examine the reasons that cause these repairs. The results indicate that directionality has some impact on the interpreting performance of student interpreters, but such impact is negligible on the performance of professionals. The results also show that expertise helps professional interpreters cope with the challenge caused by directionality better in comparison with student interpreters, even with an average of 3.5 years’ experience. Findings in this study provide new insights on the understanding of disfluencies and repairs through interpreters’ performance. In addition, the study contributes to closing the current gaps in the literature regarding the impact of directionality on disfluencies and repairs in English<>Chinese SI and presents pedagogical implications for SI training in these two directions.
Caminhos da crítica psicanalítica
Authors: Rios Cleusa
Published: June 2021

Entrevista com Cleusa Rios Passos, professora titular da Faculdade de Filosofia Letras e Ciências Humanas da Universidade de São Paulo, que tem experiência na área de Letras, com ênfase em Teoria Literária, atuando principalmente nos seguintes temas: Guimarães Rosa, estudo das formas narrativas e confluências entre crítica literária e psicanálise. Desde 2005, coordena (com outro docente) o grupo de pesquisa "Crítica Literária e Psicanálise". Entrevista: Elisabeth CardosoEdição: Ana Paula Rodrigues da Silva, Thiago Fonseca (TV-PUC)Música: PIPA estúdio
PHYSICOCHEMICAL CHANGES OF DWARF BANANA (Musa acuminata) DURING VACUUM PACKAGING STORAGE
Authors: Marpaung David Septian Sumanto , Cahyani Dwi , Utari Ni Wayan Arya , Indriyani Anggia , Apriliani Resa
Published: June 2021

Banana is tropical fruit contain health nutrition and fiber. Dwarf banana is one of type banana that well growth in Indonesia, particularly in Lampung Province. However, its economic value become exported commodities is limited by its short shelf life. In this study, the physicochemical changes were observed under vacuum packaging storage, in order to know the potency of vacuum packaging to prolong the shelf life of dwarf banana. The results showed that the vacuum packaging could reduce weight loss compare to other treatments. The maintenance of green color by vacuum packaging was also showed positive result. Furthermore, the dwarf banana under vacuum packaging storage was also showed lowest TSS, in other words, the dwarf maturity could be delayed. These results suggested the vacuum packaging could be used as potential packaging for dwarf banana Keywords: dwarf banana, vacuum packaging, postharvest, physicochemical properties