bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnostic Value of Ultrasonography Combined with Hysteroscopy in Intrauterine Space‐Occupying Abnormalities
Authors: Xia Zongbao , Jin Hong
Published: August 2022

The aim of this study was to analyze the diagnostic significance of ultrasonography combined with hysteroscopy for intrauterine space‐occupying abnormalities. A total of 99 patients with uterine space‐occupying abnormalities treated in hospitals were enrolled. The patients were divided into three groups according to different disease types: the submucosal myoma group, endometrial polyp group, and placenta residue group, with 33 patients in each group. The differences and diagnostic effects in intrauterine ultrasound, hysteroscopic findings, and surgical histopathology were observed in each group. Outcome measures: it was to compare the sensitivity, specificity, and accuracy of intrauterine ultrasound and angiography for intrauterine space‐occupying lesions using surgical and pathological examination methods as the gold standard; the relationship between the location, number, size, appearance, and serosal layer of intrauterine lesions was clearly shown; the location, number, appearance, and echogenicity of space‐occupying abnormalities under hysteroscopy were observed. The results showed that the diagnostic rates of endometrial polyps, submucous myoma, and residual placenta were 90.9%, 80.8%, and 72.7%, respectively. However, the sensitivity, specificity, and accuracy of ultrasonography in the diagnosis of endometrial polyps were 90.0%, 66.7%, and 87.9%, respectively; those of hysteroscopy in the diagnosis of endometrial polyps were 96.7%, 66.7%, and 93.9%, respectively; and combined diagnosis was 96.7%, 100.0%, 97.0%, 100.0%, and 75.0%. The sensitivity, specificity, and accuracy of ultrasonography in the diagnosis of submucous myoma of the uterus were 88.9%, 50.0%, and 81.8%, respectively; those of hysteroscopy in the diagnosis of submucous myoma of the uterus were 96.3%, 83.3%, and 93.9%, respectively; and combined diagnosis was 100.0%, 83.3%, 97.0%, 96.4%, and 100.0%. The sensitivity, specificity, and accuracy of ultrasonography in the diagnosis of uteroplacental remnants were 87.5%, 66.7%, and 81.8%, respectively; those of hysteroscopy in the diagnosis of uteroplacental remnants were 91.7%, 77.8%, and 87.9%, respectively; and combined diagnosis was 95.8%, 88.9%, 93.9%, 95.8%, and 88.9%. In summary, ultrasonography combined with hysteroscopy can improve the diagnostic sensitivity and accuracy for intrauterine space‐occupying abnormalities.
Design and Construction of an Interactive Intelligent Learning System for English Learners in Higher Education Institutions
Authors: Chen Ping
Published: August 2022

At present, the traditional teaching mode of English teaching in higher vocational institutions is not compatible with the characteristics and teaching objectives of higher vocational education under the new situation. The rapid development of interactive multimedia technology has brought a new teaching style and experience to English basic education. Interactive teaching mode breaks the shackles of traditional teaching mode and focuses on cultivating students’ English language application ability and communicative ability. By using interactive multimedia technology, to begin with, students can improve their English communicative ability more effectively in several aspects, including stimulating their interest in speaking, creating an English-speaking environment, and mobilizing their subjective initiative, and can organically integrate with the learning of professional knowledge to lay a foundation for employment. This paper proposes an interactive intelligent learning system based on artificial intelligence algorithms. This new English teaching system with the interaction theory realizes the transformation of a new student-centered teaching mode, which is a great contribution to English classroom learning in higher education institutions.
The Use of Artificial Intelligence for Smart Decision-Making in Smart Cities: A Moderated Mediated Model of Technology Anxiety and Internal Threats of IoT
Authors: Alloulbi Abdelmenem , Öz Tolga , Alzubi Ahmad
Published: August 2022

With the rapid development of artificial intelligence (AI), AI for smart decision-making is attracting a lot of attention, but research on this topic in smart cities is not yet comprehensive. Thus, the current research aimed to examine the direct and indirect (via technology anxiety) relationships between artificial intelligence (AI), technology anxiety, and smart decision-making (SDM). The research article also examines the moderating role of internal threats of IoT on AI and technology anxiety and the relationship between AI and smart decision-making. 614 cross-sectional data gathered from participants from public and private sectors in Turkey were utilized to investigate the aforementioned relationships. The results indicated that AI had a positive influence on smart decision-making. AI contributes negatively to technology anxiety. Technology anxiety has a negative effect on smart decision-making. Technology anxiety partially mediated the direct effect of AI on smart decision-making. The results revealed that internal threats of IoT moderated the negative relationship between AI and artificial intelligence, such that the negative relationship is further strengthened when internal threats of IoT are high. The results also indicated that internal threats of IoT moderated the positive direct relationship between AI and smart decision-making, such that the positive relationship is weakened when internal threats of IoT are high. The findings present crucial practical implications for government and local authorities in building smart cities.
Effects of Quantitative Nursing Combined with Psychological Intervention in Operating Room on Stress Response, Psychological State, and Prognosis of Patients Undergoing Laparoscopic Endometrial Cancer Surgery
Authors: Chen Xiaojing , Li Huiyan , Wang Shouyan , Wang Yu , Zhang Li , Yao Dandan , Li Li , Gao Ge
Published: August 2022

Objective. To investigate the effects of quantitative nursing and psychological interventions on stress response, mental health, and prognosis in endometrial cancer patients having laparoscopic surgery. Methods. The random number table approach was used to identify and split 98 patients with endometrial cancer undergoing laparoscopic surgery at our hospital’s Obstetrics and Gynecology Hospital (

n
=
49

) into observation and control groups (

n
=
49

) from May 2020 to February 2022. Both groups received standard care in the operating room, while those in the observation group received quantitative and psychological interventions in the operating room. Both groups were compared for perioperative markers, stress indicators, coping strategies, and pain levels. Results. In terms of age, TNM stage, or pathology, there was no statistically significant difference between the two groups (

P
>
0.05

). Both the observation and control groups experienced statistically significant (

P
<
0.05

) reductions in the perioperative markers of operation time, intraoperative blood loss, and overall hospital stay. Both groups’ SAS and SDS scores were lower than they had been prior to surgery, but the observation group had lower scores than the control group, and these differences were statistically significant (

P
<
0.05

). Postsurgery, the observation group’s cortisol and adrenaline levels were lower than those of the control group, and both groups’ levels were higher than before surgery, with statistical significance (

P
<
0.05

) in both groups. Neither coping style nor pain level differed significantly between the two groups before surgery (

P
>
0.05

). Postoperatively, while yield item scores were lower and faces scores were higher than the control group, the observation group’s avoidance item score was lower than the control group. All with statistical significance. There were substantial differences in NRS SCORE between observers and controls. Conclusion. After laparoscopic surgery to remove endometrial cancer, patients may benefit from the combination of quantitative nursing and psychological intervention in the operating room to alleviate postoperative anxiety and sadness and reduce stress reaction.
Performance Test and Improvement of Computer Network Virtualization Software in Cloud Computing Environment
Authors: Liu Wei
Published: August 2022

In order to make up for the problems of inconveniences, unavailability, differences, and exclusivity in the performance test of the computer virtual network software in the cloud computing environment, a method of building a distributed system performance test platform based on cloud computing is proposed. The distributed system performance test method based on the decision tree, the common performance index test method, and the resource scheduling method in the cloud environment is mainly adopted, and the cloud computing and the automatic performance test technology are combined so as to build a prototype system of the cloud performance test platform. Experimental data show that the CPU utilization and the memory utilization can be reduced to 32% and 30%, respectively, by using this method. It is about 30 times better than the result before application. The results show that it can improve the efficiency, availability, and convenience of software performance test greatly. Also, it also can improve the software performance to facilitate people’s life and work in the cloud computing environment.
An Atypical Presentation of Pyridoxine-Dependent Epilepsy Diagnosed with Whole Exome Sequencing and Treated with Lysine Restriction and Supplementation with Arginine and Pyridoxine
Authors: Kim Jiyoung , Pipitone Dempsey Angela , Kim Sun Young , Gunay-Aygun Meral , Vernon Hilary J.
Published: August 2022

Pyridoxine dependent-developmental and epileptic encephalopathy (PD-DEE) or pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disorder caused by biallelic pathogenic variants in ALDH7A1. It classically presents as intractable infantile-onset seizures unresponsive to multiple antiepileptic drugs (AEDs) but with a profound response to large doses of pyridoxine (B6). We report a case of PDE with an atypical clinical presentation. The patient presented at 3 days of life with multifocal seizures, fever, increased work of breathing, decreased left ventricular systolic function, and lactic acidosis, raising suspicion for a mitochondrial disorder or infectious process. Within 1.5 weeks of presentation, seizure activity resolved with antiepileptic therapy. Whole exome sequencing (WES) revealed homozygous pathogenic variants in ALDH7A1 (c.1279G > C, p.E427Q) and confirmed the diagnosis of PDE. Follow-up biochemical testing demonstrated elevated urine pipecolic acid. In the second week of life, the patient was initiated on triple therapy, including pyridoxine supplementation, low lysine diet, and arginine supplementation, which he tolerated well. Urine pipecolic acid levels responded accordingly after initiation of therapy. Our case illustrates the diagnostic challenges in PDE, the utility of rapid WES in such cases, and the response in urine pipecolic acid to therapy.
Protection System Design of Induction Motor for Industries
Authors: Shaikh Shoaib , Kumar Dileep , Hakeem Abdul , Soomar Arsalan Muhammad
Published: August 2022

The fundamental and durable structures of induction motor, as well as their low manufacturing cost, make them popular components in a wide range of current applications. Providing a safety net for employees is a must-have for businesses. This project’s motivation for improvement is to provide industrial motors, lift motors, pumps, and so on with safety. An induction motor’s primary goal is to protect it from problems, such as single phasing and overheating, as well as other issues. Providing industrial motors, pumps, lift motors, and other similar devices with security is a major motivation behind the emergence of this issue. Any of the three phases missing or the motor temperature above the predetermined threshold causes the motor to stop instantly. Three one-stage transformers are connected to a three-phase power supply in the system. Power will be cut to the transformer circuit if any phase is available. Motors can be turned off by relays sending a signal to the four-pole contactor. As a result, the motor’s three-phase power supply has been cut off. Temperature readings are taken from a thermistor (DHT22) that is attached to the motor. At higher temperatures, the three-phase supply will be cut off by a four-pole contactor, and the motor will shut off. This manuscript resolves the uses transformers to solve the problem of single phasing. Also, our project addresses the issue by using microcontroller. It senses all the three phases and decides whether to supply power to induction motor or to disconnect. It deals with the temperature problem, and it uses a thermistor to disconnect the circuitry, whereas in our project, a microcontroller senses the overwhelming temperature and acts accordingly, i.e., give a signal and then move towards disconnection.
[Retracted] Closed Home Physical Education Teaching Model and Response Strategies Based on Big Data Technology
Authors: Xu Guohong
Published: August 2022

Online teaching is carried out nationwide in the context of the new crown epidemic prevention and control, and physical education, as one of the compulsory courses in schools and universities, is included within the content of online line lessons. Online physical education teaching is a new approach and attempt to switch from an auxiliary teaching tool to the main teaching tool. The subject matter, target audience, teaching methods, and content of physical education classes have changed dramatically. The development of online physical education has played an important role in popularizing the concept of “sports for life” and establishing the concept of lifelong exercise. Through the analysis and research on the characteristics of online physical education, we propose the measures to promote the overall online teaching ability and level of physical education teachers in the postepidemic period, gradually promote the reform of online and offline physical education, and promote the integration of school physical education and social sports, as well as to build a physical education teacher training system that integrates online and offline development and improve and strengthen the management of Internet physical education resources. Since the teaching effect of online teaching is limited by the teaching means and content, which leads to the low accuracy of the evaluation of online sports teaching effect, for this reason, this paper designs a model based on big data technology and artificial intelligence algorithm for enhancing closed home sports teaching, obtains the overall situation of online physical education by using convolutional neural network to process physical education video sequences, and improves the system performance by embedding the algorithm into the big data framework, to avoid the interference of teaching environment and complete the evaluation of high precision online sports teaching effect. The experimental results show that the proposed method evaluation can improve the computing rate based on ensuring the high accuracy evaluation of physical education online teaching effect.
Physicochemical Properties and Fertility Assessment of Soils in Foumban (West Cameroon)
Authors: Lotse Tedontsah Vivien Piercy , Mbog Michel Bertrand , Ngon Ngon Gilbert François , Edzoa Robert Christel , Tassongwa Bernard , Bitom Dieudonné , Etame Jacques
Published: August 2022

Foumban is located in the West Cameroon Highlands, precisely in the Noun Valley. Given the low productivity recorded in this locality, this study aims to assess the state of soil fertility in this locality in order to redefine the major agro-ecological complexes in Cameroon. In order to achieve this objective, ninety (90) soil samples of this area were studied in order to determine their physicochemical parameters, namely, soil organic carbon (OC), total nitrogen (N), available P, total P, exchangeable cations (Ca, Mg, K, and Na), cation exchange capacity (CEC), and pH of water. The results obtained showed that the soils of Foumban present three classes of fertility, namely: class one (01) includes soils with a good level of fertility that are plaggic hortic NITISOLS (arenic) (NIpha), the chernic arenic UMBRISOLS (UMca), umbric arenic FERRALSOLS (Flua), mollic fragic NITISOL (hortic) (NImfh), the cambic hortic FERRALSOLS (plaggic) (FLchp) on basalts, umbric pisoplinthic PLINTHOSOLS (haplic) (PLuph), nitic CHERNOSOLS (pretic) (CHnp), and cambic FRAGISOLS (plaggic) (FGcp) with an area of about 528.71 Km2. Class two (02) includes soils with an average level of fertility that are the pretic UMBRISOLS (UMp) only, on an area of about 226.14 Km2. Class three (03) includes soils with a poor level of fertility that are the hortic FERRALSOLS (plaggic) (FLchp) on trachytes and the cambic FRAGISOLS (plaggic) (FGcp) with an area of about 38.47 Km2. Principal component analysis (PCA) has revealed that the parameters that control fertility in Foumban soils are C/N, pHeau, Ca, CEC, OM, P, and Mg. An amendment of these soils in organic fertilizer (fluent, compost, and manure) would facilitate the formation of the clay-humus complex; thus, allowing good retention of water in the soil.
Application of Image-Fusion 3D Printing Model in Total En Bloc Spondylectomy for Spinal Malignant Tumors
Authors: Wang Yushan , Xiang Yi , Tian Qiaoqiao , Luo Wei , Fan Hao , Ren Peng , Lv Zhi , Lv Jia , Bai Junjun , Qiao Xiaochen , Feng Yi
Published: August 2022

Purpose. To examine the effects of 3D printing model in total en bloc spondylectomy (TES). Methods. We performed a retrospective chart review of 41 cases of spinal tumors at our institution between 2017 and 2020, in which TES was applied. There were 19 cases with 3D printing model and 22 cases without 3D printing model. Operation time, intraoperative blood loss, excision range, complications, VAS, and ASIA grades were recorded. Statistical methods were used to analyze the data. KaplanMeier survival curve was made to evaluate the survival. Result. There were significant differences in intraoperative blood loss between the two groups. The rate of R0 resection and tumor envelope preservation were higher in 3D group than that in non-3D group. In 3D group, the complications included surgical site infection (5.2%) and cerebrospinal fluid leak (15.7%). In non-3D group, the complications included cerebrospinal fluid leak (27.3%) and nerve root injury (13.6%). The pain and neurological dysfunction were significantly relieved before and after surgery in 3D group. However, the neurological relief in non-3D group patients was not complete. The VAS scores of non-3D group at 6 months after surgery were much higher than that of 3D group. Conclusion. The application of 3D printing model not only helps surgeons observe the morphology, invasion range, and anatomic relationship of the tumor preoperatively, but also assists surgeons to judge, locate, and separate the tumor intraoperatively. For spinal malignancies, the 3D printing model is worth promoting.
Lightweight Artificial Intelligence for Secure Data Communication in Energy-Constrained Healthcare Devices
Authors: Pande Suyog Vinayak , Nattarkannan K. , Rama Bai M. , Kapila Dhiraj , Anandan P. , Mishra Nilamadhab , Abera Worku
Published: August 2022

Logistics is the transfer of goods from one place to another, mostly from the production house to the customers. A logistics network is a set of operations that involve designing, production, and marketing the goods. Cold-chain logistics are those that needed to be transported in a cold refrigeration right from the production house to the customer. A secured networking model is essential to handle the logistics networks. In this article, we are going to see an intelligent secured networking model to identify the optimal path for cold-chain logistics to hospitals. The optimal pathfinder is used to find the path between point A to point B, which is short and best. It also considers the road traffic and cost of transport. The cold-chain logistics to the hospitals include medicines and vaccines, which are to be stored at a particular temperature. Thus, path optimization is more essential in cold-chain logistics to hospitals than other types of logistics. In this research, the bee-ant optimization algorithm (BAOA) is proposed to perform the intelligent transportation to the hospitals. The proposed algorithm is compared with the existing ant colony optimization (ACO), bee colony optimization (BCO), and neural network model. From the results, it can be observed that the proposed algorithm shows 98.83% for the accurate delivery of logistics to the hospitals.
Customer Responses for Menu-Less Restaurants under Information Asymmetry
Authors: Yang Ting-Chen , Chen Yu-Chuan
Published: August 2022

Menu-less (or tasting menu, Omakase) restaurants deliberately attempt to create an atmosphere of information asymmetry. This study explores this concept, identifying what factors make customers willing to forgo product information, whether hiding information can create curiosity about food, and what alternative signals can be used to gain customers’ trust. We found that information asymmetry can positively affect food curiosity, which in turn positively affects service quality. That is, food curiosity mediates the relationship between information asymmetry and service quality. Therefore, freshness, customization, and innovation appeared to be essential determinants for menu-less restaurants to operate well. In our analysis of online reviews, we synthesized quantitative and qualitative approaches, and the results serve as a reference for the management of menu-less restaurants.
Radius and Differential Subordination Results for Starlikeness Associated with Limaçon Class
Authors: Saliu Afis , Jabeen Kanwal , Al-shbeil Isra , Oladejo Semiu Oladipupo , Cătaş Adriana
Published: August 2022

In this study we investigate the sharp radius of starlikeness of subclasses of Ma and Minda class for the ratio of analytic functions which are related to limaçon functions. This survey is connected also to the first-order differential subordinations. In this context, we get the condition on

β

for which certain differential subordinations associated with limaçon functions imply Ma and Minda starlike functions. Simple corollaries are provided for certain examples of our results. Finally, we present several geometries related to our study.
Analysis on the Nonlinear Impact of Financial Risks on CO2 Emissions: Designing a Sustainable Development Goal Framework for Asian Economies
Authors: Huang Xuan , Chen Meihua
Published: August 2022

For the purpose of coping with or eliminating the influence of carbon dioxide emissions effectively, it is crucial to apply the green investment models to carry out a qualitative analysis of carbon dioxide emission evolution. The effect of financial risks on the implementation of the carbon dioxide emission limit is essential for the distribution of resources, and it is necessary to summarize the patterns and make innovations in the process of limiting the emissions of carbon dioxide effectively. In the case of fully complying with the principles of low‐carbon economic development and related policy protection, the appropriate model for low‐carbon economic development is identified. In this article, the multivariate primary nonlinear model is applied to the analysis of the nonlinear influence of financial risks on carbon dioxide emissions to cope with the problem of financial risks on carbon dioxide emissions at present. In this method, a multivariate primary nonlinear model is established based on the detailed analysis of the financial development features, and the parameters are optimized mainly from various aspects such as the structure of the model, the features of data, and the dynamic changes of the model so as to obtain the optimal values for the parameters of the constructed multivariate primary nonlinear model. The results of the practical case analysis indicate that the influence of financial risks on the limits of domestic carbon dioxide emissions is differentiated in accordance with the results and related categories. Only in this way can the regional division of carbon emission factors be properly classified. The relationship between economic growth and carbon emission increase and changes indicates that effective strategies for carbon emission reduction should be adopted. The established panel data model is used to carry out an in‐depth analysis of the influence of carbon dioxide limitations in Asian countries.
Efficient Synchronous Real‐Time CADe for Multicategory Lesions in Gastroscopy by Using Multiclass Detection Model
Authors: Ku Yiji , Ding Hui , Wang Guangzhi
Published: August 2022

Often more than one category of lesions in patients’ gastrointestinal tracts need to be found in the endoscopic examination. Therefore, there is a need to establish an efficient synchronous real‐time computer‐aided detection (CADe) system for multicategory lesion detection. This paper proposes to build a system with a multiclass detection model based on the YOLOv5 to detect multicategory lesions synchronously in real‐time. Two joint detection CADe systems using multiple single‐class detection models with the same structure in parallel or series are established for comparison. A retrospective dataset containing 31117 images from 3747 patients is used in this study. To train the model, various online data augmentation methods and multiple loss functions are used. The proposed CADe system can synchronously detect cancers, gastrointestinal stromal tumours, polyps, and ulcers from different quality input images with 98% precision, 89% recall, and 90.2% mAP. The detection speed is 47 frames per second with a 0.04 s latency on a PC workstation. Compared to the two joint detection CADe systems, the proposed system is more accurate with faster speed and lower latency. Two extra experiments indicated that the lesion detection model based on YOLOv5x could provide better performance than other common YOLO structures and that different accuracy metrics and lesion categories have different requirements for the number of training images. The proposed synchronous real‐time CADe system with the multiclass detection model can detect multicategory lesions with high accuracy and speed and low latency on limited hardware. It expands the clinical application of CADe in endoscopy and uses expensive labelled medical images more efficiently than multiple single‐category lesion models for joint detection.
Management Strategies and Imaging Observation of Early and Delayed Intelligent Treatment of Meniscus Sports Injury under Knee Osteoarthroscopy
Authors: Deng Tong , Li Xu , Guo Zhe , Guo Shuang , Zhou Yan , Zhang Wei , Zhang Ying
Published: August 2022

Objective. To investigate the meniscus characteristics of knee osteoarthritis and its guiding significance for minimally invasive surgery. Methods. A total of 100 patients with knee meniscus sports injuries who were treated in our hospital from January 2019 to January 2022 were selected as the research subjects and were grouped according to the interval between injury and surgery, with an interval of 2 months: the early group (53 cases) within 2 months and the delayed group (47 cases) with an interval of more than 2 months. The distribution of intraoperative complications in the two groups was observed and recorded, and the changes in pain degree, joint range of motion, knee joint function, and quality of life scores before and after operation were compared between the two groups. Results. The postoperative VAS score, range of motion, Lysholm score, IKDC knee subjective function score, and quality of life score were significantly improved in both groups (

P
<
0.05

). The incidence of intra-articular cartilage injury in the delayed group was significantly higher than that in the early group (

P
<
0.05

). The patellofemoral cartilage injury was the main part of intra-articular cartilage injury in the two groups, and the incidence of patellofemoral cartilage injury in the delayed group was significantly higher than that in the early group (

P
<
0.05

). The cartilage damage was mainly cartilage damage, and the grades I-II and III-IV cartilage damages were significantly increased in the extension group. Conclusion. Meniscal injury in knee osteoarthritis has certain microscopic characteristics. In this paper, the microscopic classification of meniscus injury in knee osteoarthritis is helpful to guide microscopic surgery and improve the minimally invasive knee osteoarthritis effect of surgical treatment.
The Potential of Sino–Russian Energy Cooperation in the Arctic Region and Its Impact on China’s Energy Security
Authors: Zhang Ke , Hu Maixiu , Dang C. N.
Published: August 2022

The Sino–Russian Arctic energy cooperation is a successful example based on the comprehensive strategic partnership between the two countries. In order to analyze the impact of Sino–Russian oil and gas resources cooperation in the Arctic on China’s energy security, this paper selects 11 influencing factors such as energy self-sufficiency rate and uses the energy security index method to evaluate the three dimensions of energy supply, demand, and environmental security. The assessment results show that China’s energy security is mainly affected by the over concentration of energy import sources. At the same time, energy demand and environmental security will also have an important impact on China’s energy security. However, relative to energy demand, environmental security factors such as the proportion of clean energy consumption and channel safety factor have a greater impact on China’s energy security. After China and Russia strengthen cooperation in oil and gas resources in the Arctic, China’s energy security index is expected to increase from 0.4419 in 2020 to 0.5412 in 2025. Therefore, China can use technology, funds, scientific research, and other support to carry out all-round cooperation with Russia in the Arctic waterway, oil and gas exploration and development, and Arctic scientific research.
The Effects of Sodium Propionate Supplementation in the Diet with High Soybean Meal on Growth Performance, Intestinal Health, and Immune Resistance to Bacterial Infection in Turbot (Scophthalmus maximus L.)
Authors: Sun Huiyuan , Zhang Jinjin , Wang Wentao , Shao Rui , Liang Shufei , Xu Weiqi , Li Mingzhu , Ai Qinghui , Mai Kangsen , Wan Min
Published: August 2022

Short-chain fatty acids (SCFAs) are the products of the microbial fermentation of dietary fiber in the intestine. Acetate, propionate, and butyrate are the most abundant SCFA metabolites and play an important role in maintaining host health. This study was aimed at investigating the effects of sodium propionate (NaP) supplementation in the diet with a high proportion of soybean meal (SBM) on the growth, inflammatory status, and anti-infectious ability in juvenile turbot. Four experimental diets were designed: (1) fish meal- (FM-) based diet (control group), (2) SBM protein replacing 45% FM protein in the diet (high SBM group), (3) 0.5% NaP supplementation in the high SBM diet (high SBM+0.5% NaP group), and (4) 1.0% NaP supplementation in the high SBM diet (high SBM+1.0% NaP group). The results confirmed that the fish fed the high SBM diet for 8 weeks showed the decreased growth performance, the typical enteritis symptoms, and the increased mortality responding to Edwardsiella tarda (E. tarda) infection. However, 0.5% NaP supplementation in the high SBM diet promoted the growth performance of turbot and restored the activities of digestive enzymes in the intestine. Moreover, dietary NaP ameliorated the intestinal morphology, enhanced the expression of intestinal tight junction proteins, improved the antioxidant capacity, and suppressed the inflammatory status in turbot. Finally, the expression of antibacterial components and the resistance to bacterial infection were increased in NaP-fed turbot, especially in high SBM+1.0% NaP group. In conclusion, the supplementation of NaP in high SBM diet promotes the growth and health in turbot and provides a theoretical basis for the development of NaP as a functional additive in fish feed.
Handgrip Strength Exercises Modulate Shoulder Pain, Function, and Strength of Rotator Cuff Muscles of Patients with Primary Subacromial Impingement Syndrome
Authors: AlAnazi Amal , Alghadir Ahmad H. , Gabr Sami A.
Published: August 2022

Background. Impingement syndrome was shown to be associated with shoulder pain in 44–70% of patients worldwide. It usually occurs due to imbalance and insufficient activation of the rotator cuff (RC) muscles. Aim. This study explores the relative effects of handgrip‐strengthening exercises on shoulder function, pain, strength, and active range of motion as part of the treatment program for the patients with primary subacromial impingement syndrome. Materials and Methods. A total of 58 patients aged 18‐50 years with primary subacromial impingement syndrome were randomly enrolled to participate in this single‐blind randomized clinical trial. Out of them, only forty patients have eligibly matched the inclusion criteria and randomly assigned to one of two groups to undergo a standardized therapeutic program consisting of two sessions a week for 8 weeks. The control group prescribed ultrasound therapy, ice, and stretching exercises, while the experimental group followed the same program with the addition of handgrip‐strengthening exercises (HGSE). Both patients of conventional therapy (control) and handgrip‐strengthening exercises (experimental group) were advised to adhere also to stretching and HGSE exercises once a day at home for eight weeks. The outcomes were the shoulder function, pain intensity, muscle strength, and active range of motion of the shoulder joint. Results. Patients treated with conventional interventions plus handgrip‐strengthening exercises showed the significant improvement over time in shoulder pain and function, strength of rotator cuff muscles, and pain‐free range of motion forward flexion, abduction, and external and internal rotation through eight weeks in the experimental group compared to control patient group treated with conventional interventions. In addition, patients of both control and experimental groups showed no significant difference in the adherence to respective home‐based stretching and HGSE exercises once a day at home for eight weeks. Conclusions. Adding handgrip‐strengthening exercises to conventional intervention increases the efficacy of treatment for patients with primary subacromial impingement syndrome in terms of shoulder function, pain, muscle strength, and active range of motion.
Diagnostic Value of Endoscopic Narrow-Band Imaging Technique in Early Gastric Cancer and Precancerous Lesions
Authors: Huang Xianxin , Chen Rong , Zhao Liang
Published: August 2022

Objective. To investigate the diagnostic value of endoscopic narrow-band imaging technique in early gastric cancer and precancerous lesions. Methods. A total of 100 patients with recurrent upper gastrointestinal symptoms in our hospital from January 2017 to January 2022 were selected and divided into group A and group B according to the random number table method, with 50 cases in each group. Group A received white light endoscopy, and group B received narrow-band imaging technology combined with endoscopy. Narrow-band imaging combined with magnifying endoscopy was used to stain the area with suspicious mucosal lesions with indigo carmine and magnified observation. Results. The endoscopic image clarity of group B was significantly better than that of group A in terms of lesion outline, gastric pit, and microvascular morphology (

P
<
0.05

). There were 10 cases of early gastric cancer, 18 cases of benign lesions, and 9 cases of gastric cancer (nonearly stage); 17 cases of precancerous lesions, 12 cases of early gastric cancer, 13 cases of benign lesions, and 6 cases of gastric cancer (nonearly stage) were diagnosed by ordinary white light endoscopy. Pathological results confirmed that among the 50 patients in group B, there were 15 cases of precancerous lesions, 11 cases of early gastric cancer, 17 cases of benign lesions, and 7 cases of gastric cancer (nonearly stage). Among the 50 patients in group A, 16 were precancerous lesions, 11 were early gastric cancer, 15 were benign lesions, and 8 were gastric cancer (non early stage). In the diagnosis of precancerous lesions and early gastric cancer, the diagnostic consistency, sensitivity, and specificity of group B were better than those of group A (

P
<
0.05

); NBI combined with endoscopy in the diagnosis of precancerous lesions and early gastric cancer (

kappa
=
0.860

,

kappa
=
0.883

) was more consistent with pathological diagnosis than common white light endoscopy (

kappa
=
0.433

,

kappa
=
0.535

). Conclusion. The value of narrow-band imaging technology combined with endoscopy in the diagnosis of precancerous lesions and early gastric cancer is better than that of ordinary white light endoscopy, and it can be widely used in clinical practice.
Alpha-Mangostin-Loaded Transferrin-Conjugated Lipid-Polymer Hybrid Nanoparticles: Development and Characterization for Tumor-Targeted Delivery
Authors: Sakpakdeejaroen Intouch , Muanrit Patcharaporn , Panthong Sumalee , Ruangnoo Srisopa
Published: August 2022

Alpha-mangostin, a natural xanthone mainly extracted from the pericarp of Garcinia mangostana, has been shown to have promising anticancer properties in many types of cancer. However, the therapeutic potential of α-mangostin has been limited so far due to its poor aqueous solubility and low oral bioavailability, which limited its biopharmaceutical applications. Furthermore, α-mangostin failed to specifically reach tumors at a therapeutic concentration due and rapid elimination in vivo. We hypothesized that this drawback could be overcome by loading the drug within a delivery system conjugated to transferrin (Tf), whose receptors are overexpressed on many cancer cells and would enhance the specific delivery of α-mangostin to cancer cells, thereby enhancing its therapeutic efficacy. The objectives of this study were therefore to prepare and characterize transferrin-conjugated lipid-polymer hybrid nanoparticles (LPHN) entrapping α-mangostin, as well as to evaluate their therapeutic efficacy in vitro. We successfully prepared α-mangostin loaded LPHN using a one-step nanoprecipitation method with high drug entrapment efficiency. The conjugation of Tf to the LPHN was achieved by using the thiol–maleimide “click” reaction, leading to an increase in the particle hydrodynamic size of Tf-LPHN compared to that of unconjugated (control) LPHN (Ctrl-LPHN). Both Tf-LPHN and Ctrl-LPHN were bearing negative surface charges. Tf-LPHN and Ctrl-LPHN exhibited a sustained release of α-mangostin at pH 7.4, following an initial burst release, unlike rapid release of drug solution. The entrapment of α-mangostin in the LPHN led to an increase in α-mangostin uptake by cancer cells, and thus improved its antiproliferative activity compared to that observed with the drug solution. In conclusion, α-mangostin entrapped in the Tf-LPHN is therefore a highly promising therapeutic system that should be further optimized as therapeutic tools for cancer treatment.
Prognostic Value of GPNMB, EGFR, p-PI3K, and Ki-67 in Patients with Esophageal Squamous Cell Carcinoma
Authors: Wang Bo , Li Mengyan , Su Anna , Gao Yongmei , Shi Yan , Li Chao , Liu Wenying , Su Liping , Li Wan , Ma Yuqing
Published: August 2022

Background. GPNMB is a newly discovered tumour-promoting factor that may promote tumour cell progression by activating the PI3K/AKT pathway by EGFR. However, there are insufficient studies about GPNMB in ESCC. This study investigated the relationship between GPNMB and EGFR/PI3K pathway genes in ESCC. Methods. The expression levels of GPNMB, EGFR, p-PI3K, and Ki-67 were examined using immunohistochemistry. Statistical analysis was done by SPSS 22.0 and R. Results. GPNMB mRNA expression is higher in ESCC compared with paracancerous tissues. The expression of EGFR, PIK3CA, PIK3CB, and AKT1 was increased in GPNMB upregulated samples. GPNMB expression was positively correlated with EGFR, p-PI3K, and Ki-67 expression. GPNMB was expressed higher in the AJCC III stage, lymph node metastasis, and moderately poorly differentiated patients. EGFR was higher expressed in patients with vascular invasion; p-PI3K expression in Kazak was higher than that in Han; Ki-67 expression was higher in

tumour
 
size
≥
3
 
cm

. Patients with high expression of GPNMB, p-PI3K, and Ki-67 had worse OS. p-PI3K, Ki-67, nerve invasion, and lymphatic metastasis were independent risk factors, and postoperative adjuvant therapy was a protective factor in ESCC. Conclusion. As a tumour-promoting factor, GPNMB is expected to be a potential target for ESCC.
Improvement of Student Weariness Emotion in English Classroom Based on Intelligent Internet of Things and Big Data Technology
Authors: Pang Ya
Published: August 2022

In order to improve the recognition effect of student weariness emotion in English classroom, this paper combines intelligent Internet of Things technology and big data technology to construct an improvement model of student weariness emotion in English classroom. In the process of student facial expression recognition, according to the given grayscale threshold, this paper extracts the surface contour information from the three-dimensional volume data, extracts the student’s surface contour information, and uses triangular facets to fit to form a triangular mesh. Moreover, this paper renders a triangular mesh model and shows how to speed up the calculation of PFH. In addition, this paper proposes a Fast Point Feature Histogram, which uses an iterative closest point fine registration algorithm for image registration. Finally, this paper constructs an emotion recognition model of students’ weariness in English classroom. From the test results, it can be seen that the student weariness emotion recognition system in English classroom proposed in this paper can effectively identify students’ weariness emotion.
Identification of Novel Multi‐Omics Expression Landscapes and Meta‐Analysis of Landscape‐Based Competitive Endogenous RNA Networks in ALDH+ Lung Adenocarcinoma Stem Cells
Authors: Yang Wei , Liang Yong , Zheng Yuanyuan , Luo Haitao , Yang Xiaofei , Li Furong
Published: August 2022

ALDH+ H1975 lung adenocarcinoma stem cells (LSCs) are a rare cell population identified in lung adenocarcinoma (LUAD). LSCs can self‐renew, drive tumor initiation, growth, metastasis, and recurrence and are also the predominant cause of poor prognosis due to their intrinsic resistance to drugs and chemotherapy. Consequently, LSCs are a promising target for LUAD therapy. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), exert many significant regulatory functions in the pathogenesis of human cancers, showing the necessity for a comprehensive understanding of the mechanisms that underlie lung carcinogenesis. Nonetheless, research on many known transcripts and messenger RNAs (mRNAs) has already generated new information. Unknown biomarkers in ncRNAs and systematic and comprehensive interrelation with unknown ncRNAs and mRNAs may provide further insights into the biology of LUAD. Herein, a set of novel ncRNAs that include miRNAs, lncRNAs, and circRNAs were identified, and differentially expressed patterns of ncRNAs and mRNAs in LSCs and ALDH‐H1975 LUAD tumor cells (LTCs) were obtained using stringent bioinformatics pipelines. Through a meta‐analysis of the identified landscapes, novel competitive endogenous RNA (ceRNA) networks were constructed to reveal the potential molecular mechanisms that regulate the hallmarks of LSCs and LTCs. This study presents a summary of novel ncRNAs and the fundamental roles of differentially expressed ncRNAs implicated in the activity of LSCs and LTCs. In addition, the study also provides a comprehensive resource for the future identification of diagnostic, therapeutic, and prognostic biomarkers in LUAD.
Effect of Compound Polyethylene Glycol Electrolyte Powder on the Quality of Gastrobowel Preparation before Enteroscopy Intervention
Authors: Yuan Yongxin , Li Yuqin , Zhang Yafeng , Jiang Jing , He Yi , Liao Yimei , Yao Wenchun
Published: August 2022

Objective. To study the effect of compound polyethylene glycol electrolyte powder (PGEP) on the quality of gastrobowel preparation before enteroscopy intervention. Methods. From March 2021 to January 2022, among the patients who needed enteroscopy in our hospital, 280 patients who volunteered for this study were randomly selected as the research objects. All the subjects were randomly divided into the control group (140 cases) and the observation group (140 cases). Both groups received routine treatment before enteroscopy intervention. On this basis, patients in the control group were given 9 g of senna every day before operation, and 250 ml of 20% mannitol and 2500 ml of water were taken orally from 9:00 am to 11:00 am on the day of examination. Patients in the observation group took PGEP orally from 9:00 am to 11:00 am. The effective rate of bowel cleaning, the frequency of defecation and duration of diarrhea, the levels of blood electrolyte indexes such as Na+, K+, and Cl− before and after the intervention, and the incidence of adverse reactions were compared between the two groups. Results. The effective rate of bowel cleaning in the observation group was significantly higher than that in the control group (

P
<
0.05

). The frequency of defecation and duration of diarrhea in the observation group were significantly lower than those in the control group (

P
<
0.05

). Compared with the control group, the levels of blood electrolyte indexes in the observation group after the intervention were not statistically significant (

P
>
0.05

). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (

P
<
0.05

). Conclusion. Using PGEP for gastrobowel preparation before enteroscopy intervention can achieve high bowel cleaning efficiency, short bowel preparation time, and low incidence of adverse reactions, which does not affect the water-electrolyte balance of patients, and the psychological state of patients before enteroscopy intervention is more stable. This program is worthy of clinical promotion.