bluuebunny/crossref_metadata_2025 huggingface dataset:
6-shogaol treatment improves experimental knee OA exerting a pleiotropic effect over immune innate signaling response in chondrocytes
Authors: Gratal Paula , Mediero Aranzazu , Lamuedra Ana , Matamoros-Recio Alejandra , Herrero-Beaumont Gabriel , Martín-Santamaría Sonsoles , Largo Raquel
Published: August 2021

Background:The pathogenesis of osteoarthritis (OA) implicates a
low-grade inflammation associated to the activation of the innate immune
system. Toll like receptor (TLR) stimulation triggers the release of
inflammatory mediators, which aggravate OA severity. The aim was to
study the preventive effect of 6-shogaol (6S), a potential TLR4
inhibitor, on the treatment of experimental knee OA.
Experimentalapproach:OA was induced in C57BL6 mice by surgical section
of the medial meniscotibial ligament, which received 6S for eight weeks.
Cartilage damage, inflammatory mediator presence, and disease markers
were assessed in the joint tissues by immunohistochemistry.
Computational modeling was used to predict binding modes of 6S into the
TLR4/MD2 receptor and its permeability across cellular membranes.
Employing LPS-stimulated chondrocytes and MAPK assay we clarified 6S
action mechanisms. Results:6S treatment was able to prevent articular
cartilage lesions, synovitis, and the presence of pro-inflammatory
mediators and disease markers in OA animals. Molecular modeling studies
predicted 6S interaction with the TLR4/MD-2 heterodimer in an antagonist
conformation through its binding into the MD-2 pocket. In cell culture,
we confirmed that 6S reduced LPS-induced TLR4 inflammatory signaling
pathways. Besides, MAPK assay demonstrated that 6S directly inhibits the
ERK1/2 phosphorylation activity. Conclusion:6S evoked a preventive
action on cartilage and synovial inflammation in OA mice. 6S effect may
take place not only by hindering the interaction between TLR4 ligands
and the TLR4/MD-2 complex in chondrocytes, but also through inhibition
of ERK phosphorylation, implying a pleiotropic effect on different
mediators activated during OA, which proposes it as an attractive drug
for OA treatment.
Compensation of degradation, security, and capacity of LSB substitution methods by a new proposed hybrid n-LSB approach
Authors: Tütüncü Kemal , Çataltaş Özcan
Published: August 2021

This study proposes a new hybrid n-LSB (Least Significant Bit) substitution-based image steganography method in the spatial plane. The previously proposed n-LSB substitution method by authors of this paper is combined with the Rivest-Shamir-Adleman (RSA), RC5, and Data Encryption Standard (DES) encryption algorithms to improve the security of the steganography, which is one of the requirements of steganography, and the Lempel-Ziv-Welch (LZW), Arithmetic and Deflate lossless compression algorithms to increase the secret message capacity. Also, embedding was done randomly using a logistic map-based chaos generator to increase the security more. The classical n-LSB substitution method and the proposed hybrid approaches based on the previously proposed n-LSB were implemented using different secret messages and cover images. When the results were examined, it has been seen that the proposed hybrid n-LSB approach showed improvement in all three criteria of steganography. The proposed hybrid approach that consists of previously proposed n-LSB, RSA, Deflate, and the logistic map had the best results regarding capacity, security, and imperceptibility.
ASSOCIATION OF CD14 (C-159T) GENE POLYMORPHISM AND IRRITATED INTESTINE SYNDROME WITH OBESITY
Authors: Bilooka Yu.V.
Published: August 2021

The purpose of the study – to study the association of the polymorphic variant C-159Tof the CD14 gene in patients with irritable bowel syndrome (IBS) depending on thepredominance of diarrhea or constipation in the clinical course and the relationshipbetween genotypes of the CD14 gene (C-159T) and some blood parameters.Material and methods. The study involved 90 patients with IBS (30 men and 60women aged 22 to 56 years). The polymorphic variant of the CD 14 gene (C-159T)was analyzed by polymerase chain reaction in 90 patients with IBS without and withconcomitant obesity and 30 people in the comparison group. Blood levels of C-reactiveprotein (CRP), tumor necrosis factor α (TNFα), transforming growth factor β1(TGFβ1), interleukin-10 (IL-10), 8-isoprostane, ceruloplasmin, medium molecules andcalprotectin levels in feces were determined.Results. In patients with IBS and obesity, the frequency of TT genotype (36.7%) washigher compared to healthy subjects (TT genotype – 13.3%). Significantly higherserum levels of CRP (3.5 times and 26.7%), TNFα (1.7 times and 19.5%), TGFβ1(29.8% and 19.2%), 8-isoprostane (54.1% and 31.9%), ceruloplasmin (56.7% and33.0%), medium molecules (7, 5% and 12.9%) and calprotectin (55.7% and 37.4%) inthe feces compared to the CC and CT genotype have been determined in patients withIBS, combined with obesity, TT genotype with a predominance of diarrhea.Conclusions. The association of a polymorphic variant of the CD14 (C-159T) gene withthe risk of IBS development in obese patients has been established. The TT genotype ischaracterized by a higher content of proinflammatory cytokines (TNFα), lower levelsof anti-inflammatory cytokines (IL-10), increased CRP, more pronounced changesin the prooxidant and antioxidant blood systems (higher levels of 8-isoprostane andceruloplasmin, local inflammation (increase in calprotectin content) and severity ofendotoxicosis (higher content of medium molecules).
DIAGNOSTICS AND SURGICAL TREATMENT OF THE AORTA DISSECTING ANEURISM TYPE A, RESULTS OF SURGERY
Authors: Kravchenko V.I. , Kravchenko І.М. , Tretiak О.А.
Published: August 2021

The purpose – to evaluate the results of the surgical treatment experience of the aortadissecting aneurysms of type A.Material and methods. Surgical treatment of stratified aortic aneurysms of type Aremains one of the most difficult problems in cardiac surgery. The article presentsall experience (947 stratifying aneurysms of type A) of surgical treatment of suchaneurysms by one team. Factors that could have caused the formation of an aorticaneurysm (aortic dissection) have been identified.Results. The total hospital mortality during surgical treatment of a stratified aorticaneurysm type A was 9.7%, in addition to that – 10.1% in the acute stage and 8.4% inthe chronic stage.Conclusions. Accumulation of surgical experience, improvement of methods ofprotection of heart, brain during surgical treatment of a stratifying aortic aneurysm oftype A made it possible to achieve 4.8% of hospital mortality.
CARDIOVASCULAR CONTINUUM IN THE RESULTS OF SHORT RECORDING OF HEART RATE VARIABILITY: POSSIBILITIES OF INSTRUMENTAL DIAGNOSTICS
Authors: Nevoit G.V. , Potyazhenko M.M.
Published: August 2021

The issues of clinical significance and possibilities of using the assessment of spectralanalysis indicators of a short recording of heart rate variability for assessing thefunctional state of patients in accordance with the stages of the cardiovascularcontinuum in non-communicable diseases are described in the article.The aim of the study – to carry out a comparative assessment of the indicators of ashort recording of heart rate variability in respondents with different stages of thecardiovascular continuum in order to increase the effectiveness of measures for theprevention and treatment of non-communicable diseases in Ukraine by improvingtheir diagnosis and prevention through the introduction of modern science-intensivetechnologies into medical practice.Material and methods. 307 respondents were surveyed using the Poly-Spectrumhardware-software complex (Neurosoft, Russia). All of them underwent registrationand analysis of a short recording of heart rate variability. 200 comorbid patients withnon-communicable diseases were divided into four subgroups depending on the stage ofthe cardiovascular continuum and the degree of comorbidity. 107 functionally healthyindividuals (control group) were divided into two subgroups depending on the level ofsports training.Results. A decrease in the electromagnetic power (total and all spectral components)was found in patients with non-communicable diseases, depending on the stage of thecardiovascular continuum. The results of personalized analysis of spectral parametersin all study groups were presented and their medical-clinical interpretation was written.Conclusion. Non-communicable diseases are accompanied by a gradual decreasein the electromagnetic power (total and all spectral components) of cardiac activityin accordance with an increase in the degree of comorbidity and progression of thecardiovascular continuum. The clinical and diagnostic value of a short recording ofheart rate variability as a method for diagnosing a functional state and the expediencyof its use in a comprehensive examination of patients in a clinic of internal diseaseshave been confirmed.
Pendidikan Karakter dalam Islam: Analisis Filosofis Ibnu Miskawaih dalam Kitab Tahzibul Akhlak
Authors: Maula Atika Rofiqatul
Published: August 2021

Pendidikan karakter bertujuan untuk mengarahkan peserta didik memiliki moral atau akhlak yang baik. Karakter manusia dalam eksistensinya banyak dipengaruhi oleh lingkungannya, seperti sifat bawaan, budaya, serta pendidikan yang diterima. Dikarenakan karakter manusia yang dapat dirubah, maka jalan yang dapat ditempuh ialah melalui proses pendidikan, yaitu dengan didikan serta latihan. Karakter peserta didik dapat mengalami penurunan bahkan penyimpangan di berbagai ruang, dimana hal tersebut dapat disebabkan oleh lingkungan sekitar. Penelitian ini bertujuan untuk mengetahui bagaimana konsep pendidikan karakter menurut tokoh Islam Ibnu Miskawaih, yaitu melalui kitab karyanya â€œTahdzibul Akhlakâ€, serta relevansinya dengan pendidikan di Indonesia. Penelitian ini bersifat kualitatif deskriptif menggunakan teknis analisis isi (content analysis) dari berbagai dokumen sebagai sumber yang sifatnya primer maupun sekunder. Simpulannya adalah Ibnu Miskawaih termasuk aliran Dualis-Aktif yang berpendapat bahwa karakter manusia dipengaruhi oleh lingkungannya dan tujuan dari pendidikan karakter ialah untuk mencapai nilai kebajikan dan kebahagiaan. Relevansinya dengan pendidikan di Indonesia ialah pada mata pelajaran budi pekerti dan program pengabdian masyarakat.
Conselho Municipal de Educação de Alambari/SP: qualidade, gestão democrática e participação na concepção dos conselheiros
Authors: Giordano Daniele Xavier Ferreira , Souza Luciane Del Ben de
Published: August 2021

Este artigo analisa a compreensão dos membros do Conselho Municipal de Educação de Alambari/SP acerca dos referenciais de qualidade, gestão democrática e participação, com a finalidade de verificar quais estratégias e instrumentos são utilizados na efetividade de suas ações junto à comunidade local.  Para tanto, buscou-se como orientação metodológica a pesquisa qualitativa por meio de questionário semiestruturado. Dos 9 (nove) membros do referido conselho, apenas 3 (três) demonstraram interesse em participar da aplicação do questionário. As respostas foram analisadas a partir dos referenciais elencados e foi possível compreender que, embora a atual gestão do Conselho Municipal de Educação de Alambari/SP seja atuante e demonstre grande preocupação com o atendimento à demanda educacional local, a gestão democrática ainda é embrionária e os referenciais de qualidade da educação e participação necessitam de mais diálogo.
Análisis desde la teoría de gobernanza policéntrica de Ostrom aplicada a la figura de Parque Nacional Natural frente a los retos del posacuerdo
Authors: Zárate Yepes Carlos Alberto , López Loaiza Natalia , López Loaiza Sandra M. , Castañeda Ruiz Hugo Nelson
Published: August 2021

Se utilizan las teorías de Elinor Ostrom para mostrar alternativas de sostenibilidad territorial de bienes comunes como los Parques Nacionales Naturales, especialmente frente a los retos del posacuerdo entre el Estado y los excombatientes de las FARC. Para esto se comparan dos tendencias: la conversión de los parques en bienes públicos y con vigilancia estricta del Estado para garantizar su conservación y protección (que es la solución actual) o utilizar propuestas de cogestión (Estado-comunitarias) que involucren más a las poblaciones que habitan o se encuentran en el área de influencia. Para dicho análisis se usó como ejemplo el Parque Nacional Natural Paramillo, territorio que ha servido como corredor estratégico de los diferentes actores del conflicto y que presenta serias vulnerabilidades de cara al futuro, especialmente por las consecuencias directas e indirectas de los acuerdos de paz del Teatro Colón.
poder: una mirada desde la complejidad
Authors: Cárdenas Carrero Lisandro Andrés , Andrade Salazar José Alonso
Published: August 2021

Este es un artículo de reflexión el cual tiene como objetivo revisar la noción de poder desde la complejidad, en particular desde el paradigma de la complejidad de Edgar Morin. El poder puede ser visto desde una mirada compleja dadas sus múltiples interacciones y dominios, así como también, a razón de la necesidad de descentrar su explicación y ampliar sus posibilidades comprensivas. Como red de expansión se instala en la redistribución de las interacciones políticas, y a modo de andamiaje de cambio sociopolítico dado que moviliza, energía, recursos e información, aspectos necesarios para comprender el poder en clave de propensión transformadora colectiva.
The legal nature of the relationship for the acquisition of certificates real estate fund
Authors: Ilkiv O.V.
Published: August 2021

The article analyzes the legal nature of relations and the content of rights that arise on the basis of agreements for the acquisition of certificates of the real estate fund, and in particular the procedure for their implementation. The author considers the nature of the legal relationship, in which the main purpose is for the manager to perform the duties of the trustee with the greatest benefit and in the interests of the holders of certificates of real estate funds. An analysis of the relationship of participation in the real estate fund allows us to conclude that the trust relationship can be transformed into an absolute property right of the manager of the real estate financing fund, and investors (holders of real estate fund certificates) finance the construction.The funds invested in the real estate financing fund are used to finance a specific object. In the further investment process other participants take part, including the developer with whom the owner of the certificate of fund of real estate operations, is not in contractual relations. The owner of the certificates of the real estate fund has the right to require the manager to comply with the restrictions of the right of trust ownership in the process of fund management.The characteristics of the relationship for the acquisition of certificates of the real estate fund, where the basis of the binding relationship is property, is emphasized by differences and commonalities. The difference is that in contrast to property relations, which mostly involve the existence of the object, the moment of their occurrence, the inclusion of the object in the legal relationship is carried out by performing actions that must or may be performed by their participants, or from which you need to refrain.It is concluded that the agreement on the acquisition of FON certificates belongs to the generic type of property management agreements and the application of this agreement in the field of housing construction is due only to the fact that in this way funds are raised for its financing. transfer of ownership of housing.
Legal nature of social justice as an integral part of the principle of justice
Authors: Bakhnovskaya I.P. , Slobodyska O.A.
Published: August 2021

The article presents and solves the scientific problem of identifying the legal nature and content of social justice as an integral part of the principle of justice. The theoretical and normative basis of the study were scientific works of domestic and foreign scientists in the field of jurisprudence, philosophy, political science, sociology, history. They are devoted to the general problems of the essence of the principle of justice, its value and normative content, social and legal nature of the principle of justice, issues of legal certainty and stability of legal regulation, specific problems of implementation of the constitutional principle of justice. The problem of justice, namely social justice becomes especially relevant in the context of globalization. The practice of the Constitutional Court of Ukraine shows that the Constitution of Ukraine does not enshrine the principle of social justice in a direct form, but the entire legal system is based on the idea of justice. It is established that justice essentially reflects the realities of a society, the level of its cultural and legal maturity. It can manifest itself at different social levels, in different spatial and temporal dimensions. Thus, correlating the concepts of justice and law, justice can be considered as a legal standard with which the real socio-economic, political, financial, moral and ideological relations. Justice is not only a moral, philosophical category, but, first of all, a legal one. Justice is a legal phenomenon that relates to the very essence of law and is the distinguishing feature between law and the principles of law. In addition, it is a phenomenon of morality, because it is an idea that determines the moral principles of society. It should be noted that in some cases the application of the principle of justice is complicated, for example, when it conflicts with the principle of legality. Attention is drawn to the fact that in our state the principle of justice is not fully implemented. Social justice is the most important social value, a creative phenomenon that contributes to the reform of society on the basis of democ-racy and humanism.
Concepts and signs of public administration
Authors: Ziboreva O.B.
Published: August 2021

The article is devoted to the definition of the concept in the signs of public administration. It was found that the transition from the state-centric paradigm of state administration to the concept of a service state led to the renewal of the conceptual apparatus of administrative law. There was a need to substantiate the essence and characteristics of public administration, with the help of which the goals of the existence of a service state are realized.It is substantiated that the category “public administration” occupies an important place in modern scientific research. Scientists of public administration are mainly considered as: a) a way of realizing public interest as the interest of a certain social community, united within the territory of the state; b) as a mechanism for the implemen-tation of state policy; c) as the activity of public authorities (or state bodies and local self-government bodies) aimed at achieving socially important goals.It has been established that the definition of the concept of “public administration” in a broad sense depends to a certain extent on the level of development of democratic relations in society. If the state is characterized as democratic, then public administration can be defined as professional, paid, funded from the state and local budgets, the activities of state bodies and local self-government bodies, their officials, aimed at ensuring the rights, needs and interests of man and citizen, civil society, subjects objects of entrepreneurial activity and other participants in public relations within the framework of a unified state (public) policy. In a narrow, technocratic, understanding, public administration of any state can be considered as a set of actions of state-authorized bodies and their officials aimed at implementing public policy measures in all spheres of society.It has been proved that the signs of public administration are: a) the relationship between the direction of actions of persons directly carrying out public administration measures and state (public) policy; b) the professional nature of public administration; c) detailed legal regulation of most of the public administration activities; d) the presence of a distribution of competence between various subjects of public administration in order to avoid duplication of their functions.
Optimization of local government activities in the provision of public services
Authors: Lutsiv I.I.
Published: August 2021

The article is devoted to the study of optimization of local government in the context of public services in con-nection with the implementation of the Law of Ukraine of November 3, 2020 «On Amendments to Certain Leg-islative Acts of Ukraine on Optimizing the Network and Functioning of Administrative Service Centers services provided in electronic form». It is determined that public services provided by local governments are a type of activity of executive bodies of local self-government and municipal institutions and organizations created by them to implement informational, consulting, registration, permitting and other administrative functions performed on a budget basis, in accordance with the established regulations, technological and information cards, ensure the right of individuals and legal entities to meet the needs with minimal time and at the appropriate professional level. It is noted that technological and information cards of public services provided by local governments are a legal act adopted by local governments providing public services, which contains a consistent description of administra-tive procedures necessary for the implementation of all components of the service, as well as the standard of provid-ing such a service, which is drawn up and communicated directly to the applicant by officials of the body providing the service or authorized persons. 

It is indicated that for the state, which implements the general administrative policy in one legal field of distribu-tion of powers of local governments, the work on standardization of technological and information cards should be carried out centrally, at the state level. It is necessary to form and approve a single standard list of public services, based on all available powers of local governments.
Strategic communications as a special kind of interaction of the ministry of defense of Ukraine with other state bodies
Authors: Ponomareva D.S.
Published: August 2021

The purpose of the article is to determine the place of strategic communications in the conceptual apparatus of administrative law as a special type of interaction between executive authorities and other state bodies.The article focuses on the fact that the radical reform of the security and defense sector of Ukraine in accordance with the North Atlantic standards necessitates the development and legalization of new means and methods of pub-lic administration for national practice. These, in particular, include strategic communications, which is a type of interaction between the subjects of public relations. 

The article substantiates that strategic communications are inherently a type of information interaction, the sub-jects of which strive to achieve their goals with the help of an arsenal of special means, the most important of which is the strategic narrative. Not all aspects of strategic communications are governed by legal regulations. A complex set of means of information impact can cause consequences that cannot be objectively categorized (in particular, emotional-volitional consequences). At the same time, the organizational and regulatory aspects of strategic com-munications are unambiguously covered by the methodological apparatus of legal science.The article establishes that, in terms of content, strategic communications is a special type of information inter-action between executive authorities and other entities related to the security and defense sector.It has been proved that strategic communications as a special type of interaction between the Ministry of Defense of Ukraine and other state bodies are information interaction regulated by the norms of law and conditioned by the rights and obligations of these entities, aimed at achieving their goals. Legal regulation of the goals of strategic com-munications is carried out at the level of national strategies, doctrines and concepts adopted to ensure the defense capability of our state. In terms of the organization of strategic communications and the legal status of its subjects, relations are indicated refer to the subject of legal science. Psychological, sociological, political, economic, military aspects of strategic communications belong to the subject of study of the relevant sciences.It was determined that the directions of further scientific research should take into account the need for a more complete legalization of strategic communications in legislative acts regulating the legal status of subjects of the security and defense sector.
The european court of human rights practice influence on the national system of Ukraine
Authors: Kalyuzhna E.S.
Published: August 2021

Ukraine has recognized the jurisdiction of the European Court of Human Rights by acceding to the Convention for the Protection of Human Rights and Fundamental Freedoms. The implementation of Western concepts of the rule of law, human dignity and human rights stipulates study of the European Court of Human Rights practice, which, in accordance with national law, is the source of Ukrainian law. It is emphasized that the enshrinement of the rule of law principle in a number of laws was accompanied by a normative provision on the necessity to understand the content of this principle through the European Court of Human Rights practice.

The purpose of the study is to elucidate the general provisions characterizing the impact of the European Court of Human Rightsice practice on the national system of Ukraine.

It is substantiated that the European Court of Human Rights ensures the relevance of the Convention for the Protection of Human Rights and Fundamental Freedoms provisions, compliance of its rules with modernity, ensuring the general spirit of the Convention for the Protection of Human Rights and Fundamental Freedoms which is designed to uphold and ensure the values of a democratic society.

It is noted that in interpreting the Convention for the Protection of Human Rights and Fundamental Freedoms, the European Court of Human Rights is a kind of subject of legal doctrines making in the field of human rights affecting the legal systems of the states parties to this Convention.

Some decisions of the European Court of Human Rights in cases against Ukraine, which played a significant role in changing the national legal system, are analyzed, in particular,the decisions in the cases Koretsky and Others v. Ukraine, Natalia Mykhaylenko v. Ukraine, and Volokhy v. Ukraine.

The following legal provisions as the separation of law and the law are mentioned, giving priority to law over the law  in case of contradiction between them; understanding the content of the rule of law, the importance of legal certainty and reasoning of the decision to restrict human rights, legal equality of people, and giving real access to a fair trial to a person, etc.

It is concluded that when considering the applicants' complaints about Ukraine's non-fulfillment of its obligations in the field of human rights, the European Court of Human Rights forms legal provisions that become an integral part of the domestic legal system, in some cases they (the decisions) are the factor in changing legislation, and influence the legal doctrine transformation.
Implementation of the state information security policy of Ukraine in the context of corruption prevention: administrative and legal aspect
Authors: Shevchuk O.R , Mentukh N.F.
Published: August 2021

It is substantiated that the tasks of anti-corruption fight have the status of priority and national. The domestic legal framework on security issues should fix a clear establishment of the powers of state bodies, first of all security bodies, as well as promote interdepartmental coordination, including in the case of long-term aggression against our country, which has pronounced «hybrid» manifestations.It is established that the imperfect system of anti-corruption bodies, as well as the lack of a clear national an-ti-corruption policy and public authorities responsible for its implementation, are a significant factor in the devel-opment of Ukraine’s difficult situation in the field of corruption. Given the anti-corruption policy and its essence, functional purpose and powers, it is possible to divide the subjects of anti-corruption into basic groups of subjects, which form and ensure the implementation of national anti-corruption policy; the normative base of anti-corruption fight is created and improved.The authors concludes that in order to collect, store, analyze and summarize information on the facts of cor-ruption, including individuals and legal entities involved in corruption, in special units to combat corruption it is necessary to create and maintain operational records and centralized data banks.In the prosecutor’s office, it would be appropriate to maintain a single database on the state of anti-corruption, which should be formed on the basis of information provided by the prosecutor’s office, internal affairs and national security.Of course, in order to ensure the security of business activities, the law should now enshrine the obligation to publish information on convictions of corruption and other crimes in the economic sphere, as well as to bring indi-viduals to administrative responsibility for committing corruption offenses. In this regard, appropriate additions and changes should be made to a number of laws and, first of all, to the Law of Ukraine «On State Registration of Legal Entities, Individuals - Entrepreneurs and Public Associations» of May 15, 2003 № 755-IV. In particular, provide for the possibility of publishing in the registers of information about the potential danger of economic entities that act as contractors.
Problem aspects of qualification of mother’s murder to his newborn child
Authors: Zayets S.S. , Zayets E.Yu.
Published: August 2021

The article provides a criminal description of a privileged type of murder is the premeditated murder by the mother of her newborn child. The aim is to solve the problems of law enforcement for the correct qualification that exist in modern criminal law. The study focused on the main problematic aspects that are inherent in article 117 of the Criminal Code. Considerable attention is paid to the establishment of subjective and objective features that are inherent in this criminal offense. An inspection of the object of the crime under article 117 of the Criminal Code, which is only a person who has a special relationship with the child. The article lists the subjects who may have this connection. Problematic issues related to the time of the murder of the mother of her newborn child as an important element of the objective side were analyzed. The main problem was to clarify the time of the murder during child-birth and after. To achieve this goal was studied not only legal norms but also medical practice. The article analyzes the opinions of various scholars who have considered the period of time required to commit this criminal offense. Also in the article we paid attention to another point of discussion about an essential element of the subjective side, such as the presence of a special psychophysical state of the mother. To determine it, an analysis of the relevant rules was carried out and case law was considered. Taking into account the experience of foreign countries, we evaluated other experience and compared it with Ukrainian legislation. In addition, attention is paid to the question of the subject’s intent and the moment associated with its occurrence. In order to accurately understand the content of the crime provided for in article 117 of the Criminal Code, it was separated from the crime provided for in Part 3 of article 135 of the Criminal Code. A mother’s endangerment of a newborn child if it has caused death or other serious consequences is very similar to the murder of the mother of her newborn child, but they are different. At the end of the article there is an own opinion on possible changes in the legislation and a more detailed clarification of all necessary aspects for further correct classification of the crime.
Implementation of the principle of competitiveness of the parties and free- dom in the presentation of their evidence to the court in the criminal process of some countries of the world
Authors: Kuzmenko O.V. , Levchuk P.R.
Published: August 2021

One of the tasks of criminal proceedings is to protect the individual, society and the state from criminal offenses, which is achieved through the implementation of other tasks, in particular, by ensuring a rapid, complete and im-partial investigation and trial. In this case, any procedural decisions in criminal proceedings must be based on evi-dence that serves as a kind of link between the event of a criminal offense and the consciousness of the investigator, prosecutor, investigating judge, court. Evidence itself is the main content of criminal procedure in both the pre-trial investigation and in the judicial stages of criminal proceedings in most countries.The authors note that the Constitution of Ukraine as one of the main principles of justice provides for adversarial parties and freedom in providing the court with their evidence and proving their persuasiveness before the court. Factor The Criminal Procedure Code of Ukraine has significantly expanded the scope of this principle of the do-mestic criminal process, including in the field of evidence. Thus, the defense, as well as the prosecution, was given the opportunity to collect evidence during the pre-trial investigation, as a result of which the right of the parties and other participants in criminal proceedings to submit evidence (things and documents) is becoming increasingly important.The article also examines that the principles of criminal procedure in France include: the principle of formality, prosecution, legality, equality, dignity, protection of the victim, urgency of the trial, presumption of innocence, publicity, oral and adversarial proceedings. And the main principles of the criminal process in Germany include: the principle of formality (publicity); the principle of charge; the principle of legality and the principle of compulsory research. A characteristic feature of modern law in the field of criminal procedure in the United States is the consis-tent expansion of the institution of delegated legislation. The US Congress has delegated to the Supreme Court the right to establish rules of criminal procedure that have the force of federal law.
Verification by the prosecutor of the legality and validity of the decisions made by the investigating judge regarding the applied security measures
Authors: Merimerina I.О.
Published: August 2021

The article is devoted to clarifying what the stage of an appeal in criminal proceedings is. During the investigation, the decisions of the investigating judge concerning the application of measures to ensure criminal proceedings are con-sidered to be appealed in accordance with the requirements of the Criminal Procedure Code of Ukraine. It was empha-sized that appealing the decisions of the investigating judge during the pre-trial investigation is an important guarantee of ensuring the protection of the rights and legitimate interests of the participants in the criminal proceedings. The list of persons who have the right to file an appeal is covered. The normative regulation of appealing against the decisions of the investigating judge is analyzed. The problematic issues of this activity and the definition of ways of normative regulation are considered. In the course of the research the works of scientists on the outlined issues are analyzed.The article examines the role of the prosecutor in verifying the legality and validity of decisions made by the investigating judge on the election, change, cancellation of measures to ensure criminal proceedings. Attention is drawn to the peculiarities of the prosecutor’s appeal of certain precautionary measures. Emphasis is placed on the peculiarities of the prosecutor’s filing of appeals, the quality of preparation of response documents. The peculiarities of appealing the decision of the appellate court, ruled on the results of the review of the decision of the investigating judge on the application of certain precautionary measures, have been studied. The characteristic features of appealing certain measures to ensure criminal proceedings have been identified and investigated.It is concluded that it is expedient to supplement the Criminal Procedure Code of Ukraine with provisions on the possibility for the prosecutor to appeal the decisions of the investigating judge on seizure of property, refusal, full or partial revocation of seizure of property, revocation of seizure of property, return of temporarily seized items and documents. measures in the form of a personal obligation or refusal to apply it, application of a precautionary measure in the form of a personal guarantee, application of a measure of restraint in the form of transfer of a juvenile suspect or accused under the supervision of parents, guardians, trustees or administration of a child care institution.
Implementation of the principles and values of EU law in the national legal systems of the states parties
Authors: Vartovnik O.M.
Published: August 2021

The article considers the goals and process of formation of the European Union as a regional intergovernmental organization. The general concept of the values of the European Union in the light of the Lisbon Treaty is given. The role and place of the EU normative documents - the Charter of Fundamental Rights and the European Convention on Human Rights, in the formation of the fundamental values of the union are analyzed. The author notes that the basis of the values of the European Union is a set of fundamental human rights.The significance of the Copenhagen criteria for promoting the implementation of EU values by the state is analyzed. The Copenhagen Declaration identifies three sectors of requirements for a country aspiring to join the Community: the political sector, which requires the establishment and observance of the principles of democracy and the rule of human rights, and the economic sector, which requires fair competition. The third set of requirements is purely procedural and concerns the state’s obligation to adhere to the EU accession procedure.The author examines the state of implementation of the fundamental principles of the Union in the founding states on the example of the Federal Republic of Germany and the French Republic, as well as the implementation of Union values in countries that have recently become full members of the European Community. Thus, in Germa-ny and France today there is a fairly high level of implementation and compliance with the basic principles of the

European Union, while in Poland recently there are some problems with this. Thus, for the last 7 years, this state has violated the values of the EU in two categories at once - in the category of personal and political rights. In 2020, the number of legal grounds for abortion in the Republic of Poland was limited, violating the right to the integrity of the person and his or her inviolability, which is one of the core values of the European Union.Іn 2017, the European Commission filed a lawsuit against Poland in the European Court of Justice for violating the requirements of the EU Treaty regarding the principle of judicial independence.
Theoretical and legal aspect of determining the mechanism of ensuring human rights and features of their implementation in Ukraine
Authors: Petrechenko S.А.
Published: August 2021

The article considers the rights and freedoms of man and citizen. It is studied that human rights and freedoms are formed as a result of numerous historical preconditions that have developed the psychological need of man to freely use their abilities to think, express thoughts, engage in creativity, self-expression, work. The mechanism of law enforcement is a system of legal means that affect public relations in order to regulate, implement, etc., which includes the following elements: guarantees, legal elements of the enforcement mechanism, the process of actual implementation, conditions and factors of such process. One of the essential elements of the human rights mechanism is guarantees. Analysis of the existing concepts of guarantees in the legal literature allows us to conclude that the guarantees of individual rights and freedoms should be understood, first, certain conditions under which the fullest and most comprehensive implementation of individual rights and freedoms, and secondly, means that effectively ensure protection and protection of individual rights and freedoms in case of their illegal violation. Direct constitutional and legal guarantees are a special system of legal norms, principles, conditions, requirements and legal means and means provided by the Constitution of Ukraine and other laws. ensuring, realization, protection and defense of human and civil rights and freedoms for the purpose of their practical realization. Signs of guarantees of human rights and freedoms are that they: have a state nature; reflected at the level of relevant regulations; have a universal and continuous character; reflect the state and level of development of the main spheres of public life; have a real and appropriate nature; have the form of a complex system that has its own internal structure, the elements of which are inextricably linked and constantly interacting. Thus, guarantees are one of the main and probably the largest links in the administrative and legal mechanism for ensuring the rights of citizens.
Correlation between Stigma and Adherence to ART among HIV-Positive Adolescents: A Cross-Sectional Study
Authors:   Assistant Professor, Dept. of Community Medicine, Parul Institute of Medical Science and Research, Parul University Gujarat, India, Surti Shaily B
Published: August 2021

Despite the prominence of youth on the global agenda, young people are often left behind in national HIV responses. UNAIDS estimates indicate that AIDS-related deaths among young people are increasing. One of the reasons for this is poor prioritization of adolescents in national plans for scale-up of HIV testing, treatment and counseling services. The objectives of the current study was to: (1) To understand the social issues such as stigma and disclosure faced by them (2) To document the adherence to ART among them and study the effect of stigma on it. The cross-sectional study was conducted at HIV clinic, at ART Centre, Surat (Tertiary Care Level Institute) among adolescents between age-group 13-19 years during December-2015 to February-2016. By purposive sampling following desk review of Hospital data, 105 participants were enrolled. Frequency distribution, Factor analysis and Correlation were utilized for analysis. Around 80% feared that they will lose their friends if they came to know about their serostatus. Factor analysis yielded 2 factors- Blaming and Distancing. These two factor scores were found significantly correlated to adherence to ART. Only 7% chose to share about the status with friends outside the family. The study findings suggest that there is a need for prioritizing adolescent health among seropositives as their difficulties are different than children and adults in handling social issues like stigma due to their age and peer pressure. The lack of knowledge and fear of stigma among them if not addressed may lead to poor adherence to treatment and therefore, clinical complications.
Distribution of Metastases in Ent Area – Comparison of Theory and Practice
Authors: Behanova E , Pedan H , Hanzel P , Hajtman A , Calkovsky V.
Published: August 2021

In head and neck cancers the occurrence of nodal metastases is the most important prognostic factor. Their early diagnosis is crucial for proper treatment. Detection of early metastases is still very difficult. Predictive diagnostic methods such as the sentinel lymph node detection is limited by the occurrence of skip metastases. At our Clinic we prefer a selective neck dissection based on a surgical treatment of predilected lymphatic spread area for each type of head and neck tumor with a preservation of non-lymphatic structures of the neck. The main objective of this article is to analyze the distribution of neck metastases and to study the frequency of skip metastases in head and neck cancer.
How to Measure Patient Safety Culture? a Literature Review of Instruments
Authors: Bartonickova D , Kalankova D , Ziakova K
Published: August 2021

Introduction: Patient safety culture is described as employees’ shared values, attitudes, and behaviours in a healthcare organization. Its main goal is to improve patient safety. Assessment of patient safety culture in the hospital environment is most often carried out using self-assessment tools. Although several of these tools have been developed, their comprehensive overview is lacking in literature.

Aim: To provide an overview of instruments measuring patient safety culture in a hospital setting.

Methods: The study has a character of a narrative literature review. The search was performed in the scientific databases Scopus, ProQuest, and PubMed in January 2021. The search produced a total of 1,767 studies and was limited to language (English). The search and the retrieval process reflected PRISMA’s recommendations. The content analysis method was used in the data synthesis.

Results: We identified 24 tools for assessing the patient safety culture in a hospital setting, of which seven were developed for specific workplaces; others are considered general. Eighteen tools might be utilized by all healthcare professionals within the hospital setting and only three were designated explicitly for nurses. The most commonly used instruments were the Hospital Survey on Patient Culture and the Safety Attitudes Questionnaire.

Conclusion: Assessing a patient safety culture is considered one of the strategies for improving patient safety while increasing care quality. An appropriate tool’s choice depends on the target population, the instrument’s validity and reliability, and other aspects. Awareness of the various assessment tools can help hospitals choose the one that best suits their circumstances.
The Factors Influencing Value Creation of Halal Logistics Conceptual Framework Development
Authors: Ruangsriroj Thapanee , Suvittawat Adisak
Published: August 2021

Halal logistics has an important role in global Muslim consumer’s way of life. Muslim countries follow Shariah law strictly. Thus, Halal logistics activities must segregate facilities for halal and nonhalal products. In addition, the world Muslim population has risen steadily. It influences production and export volumes from Thailand to the global trade of halal products increasing. Logistics service providers (LSPs) have been seeking an opportunity for creating a business competitive advantage into new situations. They can create and deliver better benefits to customers than their competitors and simultaneously earn higher profits than the average of other LSPs. A variety and flexibility of logistics activities come together to make services more desirable to the target market. Although many studies have been carried out on the influence of value creation, a part of halal logistics research in Thailand is rare. For the reasons mentioned, the objective of this paper to describe the influencing value creation in halal logistics activities from a literature review to be a conceptual framework development. Establishing the issues concerning value creation of halal logistics causality are best explained by the following resource sharing, innovation solutions, and risk management.