bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Insights into the Mechanism of Modulatory Effects of Proton Pump Inhibitors
on P-glycoprotein Mediated Drug Transport of Palbociclib and Ribociclib
Authors: Desai Mrunal Pradeep , Harish Patil Prajakta , Vullendula Sai Krishna Anand , Birangal Sumit , Shenoy G. Gautham , Rao Mahadev , Dengale Swapnil Jayant , Bhat Krishnamurthy , Channabasavaiah Jagadish Puralae
Published: August 2023

Background:

Palbociclib and ribociclib are substrates of efflux transporter P-glycoprotein which plays a
key role in absorption and transport of these drugs. Proton pump inhibitors, when co-administered with them are
known to show inhibitory effect on P-glycoprotein.

Objective:

Therefore, this study aims to investigate the role of proton pump inhibitors in inhibition of P-glycoprotein
mediated efflux of palbociclib and ribociclib.

Method:

A combined approach of molecular docking and ex vivo everted gut sac model was implemented to predict
the potential of proton pump inhibitors i.e., omeprazole, esomeprazole, lansoprazole, pantoprazole and rabeprazole to
inhibit the P-glycoprotein mediated intestinal transport of palbociclib and ribociclib and study the molecular basis of
interaction taking place.

Results:

Molecular docking studies revealed that omeprazole, rabeprazole and pantoprazole bound to the ATP site of
nucleotide binding domain with binding energies of -27.53, -29.56 and -38.44 Kcal/mol respectively. In ex vivo
studies, rabeprazole and omeprazole, affected the absorptive permeability of palbociclib by 3.04 and 1.26 and
ribociclib by 1.76 and 2.54 folds, respectively. Results of molecular docking studies and ex vivo studies highlighted
that proton pump inhibitors bound to the ATP binding site to block its hydrolysis thereby inhibiting the
P-glycoprotein mediated efflux of palbociclib and ribociclib.

Conclusion:

The experimental evidence presented highlights the fact that proton pump inhibitors have potential to
inhibit P-glycoprotein, giving rise to drug interactions with palbociclib and ribociclib. Hence, monitoring is required
while proton pump inhibitors and cyclin-dependent kinase inhibitors are being co-administered to avoid adverse
events.
Salvia officinalis Improves Glycemia and Suppresses Pro-inflammatory
Features in Obese Rats with Metabolic Syndrome
Authors: Alsherif Diana A. , Hussein Mohammed A. , Abuelkasem Suzan S.
Published: August 2023

Objectives:

Obesity is regarded as the main cause of metabolic diseases and a core factor
for all-cause mortality in the general population, notably from cardiovascular disease. The
majority of people with type 2 diabetes have obesity and insulin resistance. Some evidence indicates
that an individual with obesity is approximately 10 times more likely to develop type 2 diabetes
than someone with moderate body weight.
One of the most significant therapeutic herbs, Salvia officinalis (Lamiaceae) (SAGE), possesses
potent medicinal importance. The aim of this article was to evaluate the anti-diabetic and antiobesity
activity of SAGEAE against HFD-induced obesity in rats.

Methods:

Thirty adult albino rats were randomly divided into five equal groups: control, High-fat
Diet (HFD) administrated rats, HFD + Salvia officinalis Aqueous Extract (SAGEAE) (150
mg/kg.bw.), HFD + SAGEAE (300 mg/kg.bw.) and HFD + metformin (500 mg/kg.bw.). Body
weight, plasma biochemical parameters, oxidative stress, inflammatory indicators, hepatic Phosphoenolpyruvate
Carboxykinase 1 (PCK1), Glucokinase (GK), brain Leptin Receptor (LepRb),
Glucose Transporter-4 (GLUT4), Sirtuin 1 (SIRT1) and mRNA33-5P gene signalling mRNA levels
were all assessed after 8 weeks. A histological examination of the liver was also performed to
check for lipid accumulation.

Results:

The administration of HFD resulted in increased body weight, glucose, insulin, leptin,
Total Cholesterol (TC), Triglycerides (TG), Thiobarbaturic Acid Reactive Substances (TBARS),
Monocyte Chemoattractant Protein-1 (MCP1), Interleukine-6 (IL-6) and tumor necrosis factor-α
(TNF- α) as well as hepatic PCK1, brain LepRb and adipose tissue mRNA33-5P gene expression.
However, our findings revealed a significant reduction in adiponectin, High-density Lipoproteincholesterol
(HDL-C), reduced glutathione (GSH) and Superoxide Dismutase (SOD) levels as well
as the expression of hepatic GK and adipose tissue SIRT1 and GLUT4 genes. Also, administration
of SAGEAE significantly normalized body weight, glucose, insulin, leptin, adiponectin, TC, TG,
HDL-C, TBARs, SOD, IL-6, MCP-1 and TNF-α in plasma and liver tissue of HFD-treated rats.
On the other hand, PCK1, GK, LepRb, SIRT1, GLUT4 and mRNA33-5P gene expression was
enhanced in obese rats when administrated with SAGEAE. Histological and US studies support
the biochemical, PCR and electrophoretic results.

Conclusion:

The findings imply that SAGEAE could be used as a new pharmaceutical formula in
the treatment of obesity.
Therapeutic Path to Triple Knockout: Investigating the Pan-inhibitory
Mechanisms of AKT, CDK9, and TNKS2 by a Novel 2-phenylquinazolinone
Derivative in Cancer Therapy- An In-silico Investigation Therapy
Authors: Peters Xylia Q. , Elamin Ghazi , Aljoundi Aimen , Alahmdi Mohamed Issa , Abo-Dya Nader E. , Sidhom Peter A. , Tawfeek Ahmed M. , Ibrahim Mahmoud A. A. , Soremekun Opeyemi , Soliman Mahmoud E. S.
Published: August 2023

Background:

Blocking the oncogenic Wnt//β-catenin pathway has of late been investigated
as a viable therapeutic approach in the treatment of cancer. This involves the multi-targeting of certain
members of the tankyrase-kinase family; Tankyrase 2 (TNKS2), Protein Kinase B (AKT), and Cyclin-
Dependent Kinase 9 (CDK9), which propagate the oncogenic Wnt/β-catenin signalling pathway.

Methods:

During a recent investigation, the pharmacological activity of 2-(4-aminophenyl)-7-chloro-
3H-quinazolin-4-one was repurposed to serve as a ‘triple-target’ inhibitor of TNKS2, AKT and CDK9.
Yet, the molecular mechanism that surrounds its multi-targeting activity remains unanswered. As such,
this study aims to explore the pan-inhibitory mechanism of 2-(4-aminophenyl)-7-chloro-3H-quinazolin-
4-one towards AKT, CDK9, and TNKS2, using in silico techniques.

Results:

Results revealed favourable binding affinities of -34.17 kcal/mol, -28.74 kcal/mol, and -27.30
kcal/mol for 2-(4-aminophenyl)-7-chloro-3H-quinazolin-4-one towards TNKS2, CDK9, and AKT, respectively.
Pan-inhibitory binding of 2-(4-aminophenyl)-7-chloro-3H-quinazolin-4-one is illustrated by
close interaction with specific residues on tankyrase-kinase. Structurally, 2-(4-aminophenyl)-7-chloro-
3H-quinazolin-4-one had an impact on the flexibility, solvent-accessible surface area, and stability of all
three proteins, which was illustrated by numerous modifications observed in the unbound as well as the
bound states of the structures, which evidenced the disruption of their biological function. Prediction of
the pharmacokinetics and physicochemical properties of 2-(4-aminophenyl)-7-chloro-3H-quinazolin-4-
one further established its inhibitory potential, evidenced by the favourable absorption, metabolism,
excretion, and minimal toxicity properties.

Conclusion:

The following structural insights provide a starting point for understanding the paninhibitory
activity of 2-(4-aminophenyl)-7-chloro-3H-quinazolin-4-one. Determining the criticality of
the interactions that exist between the pyrimidine ring and catalytic residues could offer insight into the
structure-based design of innovative tankyrase-kinase inhibitors with enhanced therapeutic effects.
C-C Motif Chemokine Ligand 5 (CCL5): A Potential Biomarker and
Immunotherapy Target for Osteosarcoma
Authors: Zheng Heng , Wang Yichong , Li Fengfeng
Published: August 2023

Background:

Osteosarcoma (OS) is the most common primary malignant tumor of bone
tissue, which has an insidious onset and is difficult to detect early, and few early diagnostic markers
with high specificity and sensitivity. Therefore, this study aims to identify potential biomarkers
that can help diagnose OS in its early stages and improve the prognosis of patients.

Methods:

The data sets of GSE12789, GSE28424, GSE33382 and GSE36001 were combined and
normalized to identify Differentially Expressed Genes (DEGs). The data were analyzed by Gene
Ontology (GO), Kyoto Encyclopedia of Genes and Genome (KEGG) and Disease Ontology (DO).
The hub gene was selected based on the common DEG that was obtained by applying two regression
methods: the Least Absolute Shrinkage and Selection Operator (LASSO) and Support vVector
Machine (SVM). Then the diagnostic value of the hub gene was evaluated in the GSE42572 data
set. Finally, the correlation between immunocyte infiltration and key genes was analyzed by
CIBERSORT.

Results:

The regression analysis results of LASSO and SVM are the following three DEGs: FK501
binding protein 51 (FKBP5), C-C motif chemokine ligand 5 (CCL5), complement component 1 Q
subcomponent B chain (C1QB). We evaluated the diagnostic performance of three biomarkers
(FKBP5, CCL5 and C1QB) for osteosarcoma using receiver operating characteristic (ROC) analysis.
In the training group, the area under the curve (AUC) of FKBP5, CCL5 and C1QB was 0.907,
0.874 and 0.676, respectively. In the validation group, the AUC of FKBP5, CCL5 and C1QB was
0.618, 0.932 and 0.895, respectively. It is noteworthy that these genes were more expressed in tumor
tissues than in normal tissues by various immune cell types, such as plasma cells, CD8+ T
cells, T regulatory cells (Tregs), activated NK cells, activated dendritic cells and activated mast
cells. These immune cell types are also associated with the expression levels of the three diagnostic
genes that we identified.

Conclusion:

We found that CCL5 can be considered an early diagnostic gene of osteosarcoma, and
CCL5 interacts with immune cells to influence tumor occurrence and development. These findings
have important implications for the early detection of osteosarcoma and the identification of novel
therapeutic targets.
A Bibliometric and Visual Analysis of Single Nucleotide Polymorphism
Studies in Depression
Authors: Zhang Zi , Yang Ye , Kong Wan , Huang Shanqing , Tan Yaqian , Huang Shanshan , Zhang Ming , Lu Haoyang , Li Yuhua , Li Xiaolin , Liu Shujing , Wen Yuguan , Shang Dewei
Published: August 2023

Background:

Genetic polymorphism has been proven to have an important association with
depression, which can influence the risk of developing depression, the efficacy of medications, and
adverse effects via metabolic and neurological pathways. Nonetheless, aspects of the association between
single nucleotide polymorphisms and depression have not been systematically investigated by
bibliometric analysis.

Objective:

The aim of this study was to analyze the current status and trends of single nucleotide polymorphism
research on depression through bibliometric and visual analysis.

Methods:

The Web of Science Core Collection was used to retrieve 10,043 articles that were published
between 1998 and 2021. CiteSpace (6.1 R4) was used to perform collaborative network analysis,
co-citation analysis, co-occurrence analysis, and citation burst detection.

Results:

The most productive and co-cited journals were the Journal of Affective Disorders and Biological
Psychiatry, respectively, and an analysis of the references showed that the most recent research
focused on the largest thematic cluster, “5-HT”, reflecting the important research base in this area.
“CYP2D6” has been in the spotlight since its emergence in 2009 and has become a research hotspot since
its outbreak in 2019. However, “BDNF ”, “COMT ”, “older adults”, “loci”, and “DNA methylation” are
also the new frontier of research, and some of them are currently in the process of exploration.

Conclusion:

These findings offer a useful perspective on existing research and potential future approaches
in the study of the association between single nucleotide polymorphisms and depression,
which may assist researchers in selecting appropriate collaborators or journals.
Assessment of Organ Dysfunction and Underlying Causes in Maternal
Near-miss Cases at Health Care Facilities in Doiwala Block of District
Dehradun – A Retrospective Study
Authors: Kanwar Dhanak , Chaturvedi Jaya , Singh Mahendra , Aggarwal Pradeep , Sharma Nandita , Sadiq Sabiha
Published: August 2023

Introduction:

The extent of maternal morbidity is a good gauge of a nation's maternal health care system. Maternal near-miss (MNM) cases need to be reviewed because they can indirectly contribute significantly to reducing the maternal mortality ratio in India. MNM cases can provide useful information in this context. Such women who survive these life-threatening conditions arising from complications dur-ing pregnancy, childbirth and post partum (42 days) share many commonalities with those who die be-cause of such complications.

Aim:

To assess the organ dysfunction and the underlying causes, associated/contributory factors associated with “maternal near-miss” cases in pregnant, in labor, post-partum women (upto42 days) in the health care facilities of Doiwala block, district Dehradun.

Materials and Methods:

The present study was conducted over a period of 6 months under the Department
of Community and Family Medicine, All India Institute of Medical Sciences, Rishikesh.
The cross-sectional study included the medical record files of all pregnant women attending the Department
of Obstetrics and Gynecology, in the selected healthcare facilities of Doiwala block, district
Dehradun.

:

This study was conducted as per the WHO criteria for “near-miss” by using convenience sampling
for the selection of healthcare facilities. The medical record files of all women who were pregnant,
in labor, or who had delivered or aborted up to 42 days were included from a period of 01.06.2021 –
31.05.2022

Results:

It was found that Out of the women with maternal near-miss (n=91), the majority of women
had coagulation /hematological dysfunction (n=45, 49.4%), followed by neurologic dysfunction
(n=15, 16.4%), cardio-vascular dysfunction (n=11, 12%).

:

Out of the total women with a maternal near-miss (n = 91), 10 women underwent multiple organ
dysfunctions. Of the total 91 maternal near-miss cases, the underlying cause of near-miss was obstetric
hemorrhage in almost half the participants (n=45, 49.5%) followed by hypertensive disorders
(n=36, 39.5%). Eleven women had a pregnancy with abortive outcomes (12%) and 7 women had
pregnancy-related infection.

:

It was also seen that, out of 91 near-miss women, the leading contributory /associated cause was
Anemia (n=89, 97.8%) followed by women having a history of previous cesarean section (n=63,
69.2%). Sixteen women had prolonged /obstructed labor (n = 16, 17.58%).

Conclusion:

Pregnancy should be a positive experience for every woman of childbearing age. A better understanding of pregnancy-related conditions enables early detection of complications and prevents the conversion of mild to moderate maternal morbidity outcomes to severe maternal outcomes with long-term health implications or death. There are already effective measures in place to reduce maternal and new-born mortality and morbidity.
Exploring the Experts' Perspectives on the Most Important Risk Factors of Breast Cancer in Iranian Women: A Qualitative Delphi Consensus
Authors: Roudsari Robab Latifnejad , Taghipour Ali , Najafi Tahereh Fathi , Ebadi Abbas , Shandiz Fatemeh Homaei , Manouchehri Elham
Published: August 2023

Background:

Several methods have been designed to assess the risk of breast cancer. But according to studies conducted in Iran, the risk of Iranian women could not be correctly calculated.

Objective:

This study aimed to explore the experts' perspectives on the most important risk factors of breast cancer in Iranian women.

Method:

In round one, the risk factors identified from an integrative review of literature and specialist interviews (Delphi round one) were used to design a questionnaire survey. In round two, specialists were asked to rate the importance of each risk factor. In round three, respondents were asked to reprioritize moderate important risk factors. The items considered very important in round three were included in the core risk factors set.

Results:

In the first round, a total of 119 items were obtained from the results of an integrative review of the literature and interview with experts. In round two, 30 specialists (response rate 50%) prioritized 119 risk factors of BC, and 43 low, 51 medium and 25 high-level risk factors were identified by the experts. From those, 43 low-level risk factors were removed, and 51 medium-level risk factors were carried forward to round three for consensus. No consensus was reached on any of the risk factors that went into round three (response rate 86.7%). Therefore, 25 high-level risk factors were recognized as the most important risk factors for BC in Iran.

Conclusion:

This study highlights the items that specialists feel would be most crucial to include in the clinical assessment of breast cancer risk. This study has the potential to provide an appropriate and usable tool for detecting high-risk women in primary health care in Iran.
Preparation, Physicochemical Characterization, and Stability Study of
Lippia origanoides Essential Oil-based Nanoemulsion as a Topical Delivery
System
Authors: Benitez-Llano Carlos Andrés , Florez-Acosta Oscar Albeiro , Velasquez-Polo Darsy Dayana , Mesa-Arango Ana Cecilia , Zapata-Zapata Carolina
Published: August 2023

Introduction:

Fungal diseases are a priority in research, development, and health care, according to the WHO, mainly due to Candida spp. Essential oils (EOs) of the genus Lippia have demonstrated broad antimicrobial biological activity. Previous studies identified the anti-Candida potential of a thymol/p-cymene chemotype EO from Lippia origanoides H.B.K coded “0018”. Nanoemulsions favor the biological activity of EOs and overcome limitations such as low solubility, instability against oxidizing agents, pH, light, and low permeability.
To develop, characterize, and adjust a prototype of an O/W nanoemulsion containing the "0018” EO from Lippia origanoides for its evaluation in an In vitro permeability study.

Methods:

Nanoemulsions were obtained using a high energy high shear method. Their particle size distribution, Z potential, viscosity, pH, encapsulation efficiency (EE), thermodynamic stability and the Turbiscan Stability Index (TSI) were evaluated. The nanoemulsion prototype was adjusted to improve performance characteristics and microbiological efficacy. Thymol was used as an analyte in the EO quantification using UHPLC-DAD.

Results:

An O/W nanoemulsion with hydrodynamic diameter <200 nm and polydispersity index <0.3, EE >95%, with TSI < 1.5, anti-Candida albicans efficiency >95% was obtained; permeable with a flow of 6.0264 µg/cm2/h and permeability coefficient of 1.3170x10-3 cm/h.

Conclusion:

A pharmaceutical formulation prototype is obtained that maintains the physical and physicochemical characteristics over time. Permeability is verified in an in-vitro model. It is proposed to evaluate its antifungal activity in preclinical or clinical studies as a contribution to the treatment of topical fungal diseases caused by Candida spp., through the use of biological resources and Colombian biodiversity
Bidirectional DC-DC Converter and Improved Electrical Vehicle Dynamic
Response Control
Authors: Kalaichelvan Arulvendhan , Purushothaman Srinivasan , Kamalkannan Muralikrishna , Joseph Nissy , Murugavel Roshan
Published: August 2023

Background:

In automotive applications where bidirectional power flow is
necessary to lighten the power system, dual active bridge (DAB) converters are frequently
employed. Variations in the required output voltage, erratic input voltage, and shifting loads all
have an impact on this converter. As a result, converter performance has to be improved. To
increase efficiency, the current stress of the DC-DC converter must be optimised. This paper
proposes a control scheme for the coupled inductor bidirectional DC-DC (CIB DC-DC)
converter utilising both model predictive control (MPC) and a proportional-integral (PI)
controller. The integration of these control techniques aims to enhance the performance and
efficiency of the converter.

Methods:

The MPC algorithm is employed to predict the converter's future behaviour based on
a dynamic model, taking into account system constraints and performance criteria. By
optimising the control action over a finite time horizon, the MPC algorithm ensures an optimal
response, considering the current state and anticipated changes. Additionally, a PI controller is
incorporated to augment the control strategy. The proportional component of the PI controller
enables a fast initial response to the error between the desired and actual converter outputs. The
integral component eliminates steady-state errors and provides robustness against disturbances,
resulting in improved overall system performance.

Results:

The proposed control scheme is implemented and evaluated through simulations and
experimental tests on a prototype converter. The results demonstrate the effectiveness of the
combined MPC and PI controller approach.

Conclusion:

The coupled inductor bidirectional DC-DC (CIB DC-DC) converter using MPC
can provide precise control of power flow between two voltage domains, enabling efficient
bidirectional power transfer. The predictive capabilities of MPC allow it to adapt to varying
load conditions and respond quickly to changes, ensuring stable operation and accurate
regulation of voltage and current. Overall, the coupled inductor bidirectional DC-DC converter
controlled using MPC over PI offers improved performance, efficiency, and flexibility
compared to traditional control methods. MPC can handle the complex dynamics response and
non-linear characteristics of the converter, making it suitable for bi-directional vehicle charging
applications, where precise control and high efficiency can be achieved.
A Comprehensive Model Incorporating Multiple Spatial Relations in 3D
Space
Authors: Liu Weiguang , Li Mengmeng , Zhao Yuanyuan , Gao Jixun , Wang Miao , Fang Zhenxi
Published: August 2023

Aims:

A Comprehensive Model Incorporating Multiple Spatial Relations in 3D Space.

Background:

At present, the research on two-dimensional spatial relation expression and inference
models is relatively mature, but these models cannot be used to deal with three-dimensional
spatial orientation relations. With the application of spatial orientation relations, threedimensional
spatial orientation relations are involved in many fields such as urban architectural
design, robotics, image processing, etc. Two-dimensional spatial orientation relations models
cannot satisfy the needs of three-dimensional spatial applications, so there is an urgent need to
research three-dimensional spatial object orientation relations expression and inference models.

Objective:

This work aims to provide a comprehensive model incorporating multiple spatial
relations in 3D space. The joint representation of direction, distance, and topological relations
describes more complex spatial position relations among objects.

Methods:

Based on this comprehensive model, the computational properties of interval algebra
are used to combine the directional and topological relations.

Result:

The study lays a good foundation for the formal representation and reasoning of spatial
relations between regions, enhances the analyzability of spatial relations between objects, and
improves the accuracy of spatial analysis.

Conclusion:

The main novel contribution of this paper is that we propose a comprehensive orientation
relation model, called 3D-TRD, which considers three spatial orientation relations simultaneously.
The paper gives examples to represent the position relations of two spatial objects
by comparing the RCC8 model, the 3DR46 model, and the comprehensive model to highlight the
advantages of our proposed model. Based on the model, the bidirectional mapping association
method is also used to represent the location of the spatial objects. The first advantage of the 3DTRD
model is that it represents spatial location relations more accurately than 3DR46, RCC8,
and five qualitative distances. The second advantage of the 3D-TRD model is that it proposes a
bidirectional mapping representation in three-dimensional space. The third advantage of the 3DTRD
model is that it provides a good basis for the formal representation and inference study of
the spatial relations between regions.
HUBUNGAN ANTARA LINGKAR DADA, TINGGI PUNDAK, DAN PANJANG BADAN DENGAN PRODUKSI SUSU SAPI PERAH FH LAKTASI DI BPPIBTSP BUNIKASIH CIANJUR
Authors: Bahri Toto Multiana , Salman Lia Budimulyati , Christi Raden Febrianto
Published: August 2023

Sapi perah adalah hewan ternak yang dipelihara secara khusus karena kemampuannya untuk menghasilkan susu. Produksi susu sapi yang rendah dan kualitas susu yang tidak memenuhi standar merupakan permasalahan yang sering terjadi, oleh karena itu perlu perbaikan sifat kualitatif dan kuantitatif pada sapi perah agar dapat menghasilkan produksi susu yang maksimal. Penelitian ini dilaksanakan pada bulan April-Mei 2021. Tujuan penelitian ini adalah untuk mengetahui ukuran lingkar dada, tinggi pundak, dan panjang badan sapi perah FH laktasi dan mengetahui hubungan antara lingkar dada, tinggi pundak, dan panjang badan dengan produksi susu sapi perah FH laktasi di BPPIBTSP Bunikasih Cianjur. Penelitian menggunakan metode survey dengan analisis data regresi linier berganda. Hasil penelitian menunjukkan bahwa nilai rataan Lingkar Dada (LD) pada laktasi ke-1, 2, dan 3 masing-masing sebesar 176,6 Â± 14,5 cm, 186,6 Â± 8,38 cm, dan 187,2 Â± 8,5 cm. Nilai rataan Tinggi Pundak (TP) pada laktasi ke-1, 2, dan 3, masing-masing sebesar140 Â± 13,03 cm, 138,6 Â± 3,88 cm, dan 137,4 Â± 3,22 cm. Nilai rataan Panjang Badan (PB) pada laktasi ke-1, 2, dan 3 masing-masing sebesar 151 Â± 6,87 cm, 152,5 Â± 6,68 cm, dan 158 Â± 4,22 cm. Hubungan antara lingkar dada, tinggi pundak, dan panjang badan dengan produksi susu sapi FH memiliki korelasi sebesar 0,271, yang termasuk dalam kategori rendah dengan nilai signifikansi sebesar 0,567. Disimpulkan bahwa tidak ada hubungan antara lingkar dada, tinggi pundak, dan panjang badan terhadap produksi susu sapi perah FH laktasi.
The Role of Biofertilizer in Combination with Different NPK Fertilizer Treatments on Growth Characteristics and Yield Responses of Chicken Pea (Cicer arietinum L.)
Authors:   Islamic Azad University, Hosseini Maryam , Aamani Alireza ,   Islamic Azad University, Najafzadeh Narmin ,   Islamic Azad University
Published: August 2023

This study aimed to investigate the role of mycorrhiza and humic acid in regulating soil nutrient levels and their effects on the quantitative and qualitative traits of chickpea plants. Our results showed that the application of humic acid and mycorrhiza, either individually or in combination, significantly increased the chlorophyll content of the plants compared to the control treatment. The combination of humic acid and mycorrhiza with 100% NPK levels resulted in the highest chlorophyll levels. Additionally, the combined treatment of humic acid and mycorrhiza with 100% NPK levels showed positive effects on yield-related traits, including seed yield, biological yield, number of pods per plant, and number of seeds per pod. The highest grain yield was obtained with the combined application of humic acid + mycorrhiza at the level of 100 NPK at the rate of ~8000 kg/ha, respectively. Also, the highest levels of N and P were observed with the combined application of humic acid+ mycorrhiza at 100% level of NPK. In general, the results showed that the combined use of humic acid and mycorrhiza has been able to reduce the use of NPK fertilizer by 25%. These findings suggest that the use of humic acid and mycorrhiza in combination with NPK fertilizers can enhance the growth and productivity of chickpea plants. Furthermore, this approach offers the potential to reduce the reliance on chemical fertilizers, thereby promoting sustainable cropping systems. The study highlights the importance of bio-fertilizers and organic amendments in mitigating environmental pollution and improving crop production under changing environmental conditions.
Analysis of needs for development of earthquake disaster mitigation animation videos for disabilities elementary school children
Authors: Ismail Adik , Sayekti Ika Candra , Susilawati Siti Azizah , Pramudita Dias Aziz
Published: August 2023

Earthquakes are frequent disasters in Indonesia. This disaster often causes many fatalities, so reducing the risk of an earthquake is necessary. Disaster risk reduction can be carried out with government programs, namely disaster risk reduction education which aims to reduce the threat of victims due to disasters. However, in implementing this program, there are deficiencies in media accessibility and learning media for elementary school children with disabilities. The purpose of this study was to describe the results of the needs analysis for the development of earthquake disaster mitigation animation videos. This research is a type of qualitative research. The data from this study were obtained from filling out a needs analysis questionnaire by 161 students and 121 teachers from 13 special schools in Klaten Regency, data analysis using interactive analysis. Based on the results of filling out the questionnaire to analyze the needs of students and teachers, it is known that students and teachers of SLB throughout Klaten Regency need an animated video on earthquake disaster mitigation to become one of the learning media. Students agree as much as 97.70%, and teachers agree as much as 99.20% to develop an animated earthquake disaster mitigation video. The development of earthquake disaster mitigation animation videos must follow the needs of students and teachers regarding material, language, presentation, and graphics.
E-learning assisted AIR learning model to improve students' critical thinking skills
Authors: Safarati Nanda , Zuhra Fatma
Published: August 2023

A learning innovation that combines innovative learning with online learning needs to be done to bridge pandemic conditions such as Covid-19. One of them is the e-learning-assisted AIR learning model (e-AIR). The integration of e-learning into the AIR learning model is carried out to provide learning facilities for students so they can repeat learning material anytime and anywhere. One of the competencies expected to develop in physics courses is CBC. Developing critical thinking is crucial because it is a skill most students need when facing a problem. This study aimed to determine the increase in student CBC by applying the e-learning-assisted AIR learning model for the Physics Education Study Program students at Almuslim University. This quasi-experimental study with a one-group pretest and posttest design was conducted on all Physics Education students at Almuslim University with a sample of 9 students. The research instrument used was in the form of questions adapted to the KBK indicators. Data analysis using the n-gain test. The results of this study show that the e-learning-assisted AIR learning model can improve student CBC, as seen from the percentage obtained, namely as many as five students obtained a percentage of 56%, as many as three students obtained a percentage of 33% in the medium category. As many as one student received 11%, with a low category.
Электродуговой синтез фотоактивных композиционных микрочастиц ZnO/TiO-=SUB=-2-=/SUB=-/Nb-=SUB=-2-=/SUB=-O-=SUB=-5-=/SUB=-
Authors: Гаджиев М.Х. , Оруджев Ф.Ф. , Муслимов А.Э.
Published: August 2023

The method of electric arc synthesis of photoactive multicomponent composite microparticles on the example of a ZnO/TiO2/Nb2O5 system using a low-temperature plasma generator is proposed.
Morphology and structural-phase composition of synthesized composite microparticles have been studied. Sold monstrated their record high photocatalytic activity (speed constant 128.6 · 10 − 3 min − 1)
combined irradiation with ultraviolet and visible light
Воздействие плазмы N-=SUB=-2-=/SUB=- на монослои дисульфида молибдена
Authors: Хлебников С.А. , Соловых А.А. , Манкелевич Ю.А. , Воронина Е.Н.
Published: August 2023

Based on ab initio DFT simulation results, the main processes of the interaction of thermal N atoms with MoS2 monolayers are revealed, potential mechanisms of defect formation by low-energy ions N2+ are described, and the ion threshold energy required to sulfur removal is estimated.
Влияние эффекта медленной динамики на упругие релаксационные свойства поликристаллических металлических стержней
Authors: Глазов А.Л. , Муратиков К.Л.
Published: August 2023

A theoretical model for the formation of ultrasonic signals in metallic microcrystalline rods taking into account the metastable behavior of their defective states is proposed. The influence of metastable states of the defective structure of samples on the features of changes in their resonant frequencies in ultrasonic experiments of fast dynamics is analyzed. The increase in the Young's modulus and the dynamics of changes in resonant vibrations of rods made of aluminum alloy D16T under conditions of free relaxation are explained. Based on the results obtained, the concentration of metastable defects was estimated.
Влияние выдува струи из тонкой трубки на генерацию торнадоподобного вихря и интенсификацию развивающегося закрученного турбулентного потока в наклонной канавке на стенке канала
Authors: Исаев С.А. , Никущенко Д.В. , Яновский Л.С. , Чулюнин А.Ю.
Published: August 2023

A numerical study of the effect of blowing a jet from a thin air tube on the vortex motion in an inclined groove on the wall of a plane-parallel channel is performed using StarCCM+ calculation codes. It is shown that in the range of change in the flow rate in the jet from 0 to 0.1% in fractions of the air flow rate in the channel, the blowing of the jet does not affect the self-organized tornado-like vortex in the inlet part of the groove. With an increase in the relative flow rate, the outflowing trickle is gradually drawn in, and, starting from 0.08%, it is completely captured by a helical vortex emerging from the central part of the groove with an inclination angle of 45°. In this case, the swirling flow in the tail part of the groove is intensified due to the resulting pressure drop between the zones of stagnation on the windward slope and rarefaction at the bottom of the groove.
Calculation Method of the Carbon Footprint of Products of Animal Origin Integrated with the Physiological Absorption of Carbon Dioxide: Calculation Example of the CFP of Mozzarella di Bufala Campana DPO
Authors: De Vivo Roberto , Zicarelli Luigi , Napolano Roberto , Zicarelli Fabio
Published: August 2023

The environmental impact of emissions appears to be increasingly important for food, particularly those of animal origin. The LCA (Life-Cycle Assessment) method, an internationally standardized method used to calculate the environmental impact of goods or services, in the carbon footprint, does not take into account the carbon set and consequently the subtraction of carbon dioxide by the plant biomass whether or not aimed at the production of food of animal origin. This methodology could overestimate the carbon dioxide generated to obtain plant and animal products that require their use. For the production of Mozzarella di Bufala Campana DPO, in this specific case, the masses of the various forage and cereal species used were quantified starting from the food rations of the different categories divided by age and production phase (dry, lactation, young livestock and heifers). The population includes all the animals reared in the areas covered by the DPO specification and with a milk production orientation. The carbon fixed in the forage and consequently the carbon dioxide subtracted from the atmosphere was calculated on the food mass, through the various harvesting speeds and the percentages of dry matter. The purpose of this contribution was to calculate the number of greenhouse gases emitted during the digestive and fermentative processes as well as that produced by the manure and the CO2 emitted with respiration by comparing it with the sequestration of carbon, and therefore of carbon dioxide, in all plants and all vegetable raw materials, grown in Italy and abroad, used to feed the buffaloes destined for the production of buffalo mozzarella from Campania (Mozzarella MBC) in the DPO area. The amount of greenhouse gases converted into equivalent carbon dioxide emitted during production is lower than the carbon dioxide removed from the atmosphere. For every kg of Mozzarella di Bufala Campana DPO, a total of about 52 kg of CO2eq is subtracted. Therefore, if this factor were taken into account for agricultural and animal products, the environmental impacts in terms of emissions would be reset.
Association of Catastrophic Health Expenditure With the Risk of Depression in Chinese Adults: Population-Based Cohort Study
Authors: Wang Yaping , Liang Wannian , Liu Min , Liu Jue
Published: August 2023

Background

Depression is one of the most common mental illnesses, and it may have a lasting effect on one’s whole life. As a form of financial hardship, catastrophic health expenditure (CHE) may be associated with depression. However, current evidence about the relationship between CHE and the risk of depression is insufficient.

Objective

This study aimed to explore the relationship between CHE and the risk of depression among Chinese adults.

Methods

In this study, we used 3 waves of the China Family Panel Studies (CFPS) from 2012, 2016, and 2018. The CFPS are a nationally representative study covering 25 of 31 provinces in Chinese mainland and representing nearly 94.5% of the total population. We selected eligible household heads as participants, divided them into 2 groups by CHE events at baseline (exposed group: with CHE; unexposed group: without CHE), and followed them up. Households with CHE were defined as having out-of-pocket medical expenditures exceeding 40% of the total household nonfood expenditure, and people with depression were identified by the 8-item Centre for Epidemiological Studies Depression Scale (CES-D). We first described the baseline characteristics and used logistical regression to estimate their effects on CHE events. Then, we used Cox proportional hazard models to estimate adjusted hazard ratios and 95% CIs of depression among participants with CHE compared with those without CHE. Finally, we analyzed the subgroup difference in the association between CHE and depression.

Results

Of a total of 13,315 households, 9629 were eligible for analysis. Among them, 6824 (70.9%) were men. The mean age was 50.15 (SD 12.84) years. Only 987 (10.3%) participants had no medical insurance. The prevalence of CHE at baseline was 12.9% (1393/9629). Participants with a higher family economic level (adjusted odds ratio [aOR] 1.15, 95% CI 1.02-1.31) and with the highest socioeconomic development level (aOR 1.18, 95% CI 1.04-1.34) had a higher prevalence of CHE than reference groups. During a median of 71 (IQR 69-72) person-months of follow-up, the depression incidence of participants with CHE (1.41 per 1000 person-months) was higher than those without CHE (0.73 per 1000 person-months). Multivariable models revealed that the adjusted hazard ratio for the incidence of depression in participants with CHE was 1.33 (95% CI 1.08-1.64), and this association appeared to be greater in participants without outpatient services (for interaction, P=.048).

Conclusions

CHE was significantly associated with increased risk of depression among Chinese adults. Concentrated work should be done to monitor CHE, and more efforts to ensure financial protection need to be made to prevent depression, especially for people with high health care needs.
Gender Affirmation–Related Information-Seeking Behaviors in a Diverse Sample of Transgender and Gender-Diverse Young Adults: Survey Study
Authors: Boskey Elizabeth R , Quint Meg , Xu Rena , Kremen Jessica , Estrada Carlos , Tham Regina , Kane Kaiden , Reisner Sari L
Published: August 2023

Background

Of the 1.6 million transgender and gender-diverse (TGD) people in the United States, approximately 700,000 are youth aged 13-24 years. Many factors make it difficult for TGD young people to identify resources for support and information related to gender identity and medical transition. These range from lack of knowledge to concerns about personal safety in the setting of increased antitransgender violence and legislative limitations on transgender rights. Web-based resources may be able to address some of the barriers to finding information and support, but youth may have difficulty finding relevant content or have concerns about the quality and content of information they find on the internet.

Objective

We aim to understand ways TGD young adults look for web-based information about gender and health.

Methods

In August 2022, 102 young adults completed a 1-time survey including closed- and open-ended responses. Individuals were recruited through the Prolific platform. Eligibility was restricted to people between the ages of 18-25 years who identified as transgender and were residents of the United States. The initial goal was to recruit 50 White individuals and 50 individuals who identified as Black, indigenous, or people of color. In total, 102 people were eventually enrolled.

Results

Young adults reported looking on the internet for information about a broad range of topics related to both medical- and social-gender affirmation. Most participants preferred to obtain information via personal stories. Participants expressed a strong preference for obtaining information from other trans people.

Conclusions

There is a need for accessible, expert-informed information for TGD youth, particularly more information generated for the transgender community by members of the community.
An Implementation Pilot of Web-Based Self-Training Programs on Sexual Dysfunctions in the Dutch Public Sexual Health Setting: Mixed Methods Study
Authors: Zimbile Filippo , Beek Titia , David Silke , Crutzen Rik
Published: August 2023

Background

Web-based sexual health interventions may be more acceptable to people compared with face-to-face support, given the stigma and embarrassment often associated with sexual problems. The Dutch public sexual health clinics (SHCs) conducted an implementation pilot with 4 web-based self-training programs on sexual dysfunctions (WSTPs) for young people. In addition to a basic sexuality program, the WSTPs focused on the following complaints: pain during intercourse, premature ejaculation, and no sex drive.

Objective

This study aims to gain insight into the potential reach of the freely offered WSTPs; use, acceptance, evaluation, and perceived impact of the WSTPs by young people; and evaluation and acceptance of the WSTPs by nurses of the SHCs.

Methods

A quantitative baseline measurement (BM) and a follow-up measurement (FM) were conducted among the users. In addition, qualitative data were gathered through video interviews with a sample of respondents of the FM and nurses of the SHCs to gain more in-depth insights into their assessment of the WSTPs. Participants were recruited via social media, posters, and referrals by nurses of the SHCs. Quantitative data were analyzed using descriptive statistics. Independent 2-tailed t tests and one-way independent ANOVAs were used to compare the scores between subgroups based on background characteristics. Dependent 2-tailed t tests were used to assess the possible changes between BM and FM. The interviews were analyzed using a thematic analysis.

Results

A total of 1028 young people (aged 16-24 y) completed the BM, 666 started with 1 of the WSTPs, and 104 participants completed the FM. In addition, 8 users and 8 nurses were interviewed. Of the participants who completed the BM, 87.74% (902/1028) experienced moderate (411/1028, 39.98%) to high (491/1028, 47.76%) severity of complaints, of which 20.43% (210/1028) had had them for >1 year and 27.82% (286/1028) even for ≥2 years, and 38.91% (400/1028) were dissatisfied with their sex lives. Only 8.75% (90/1028) had sought professional help in the past 2 years. At FM, users rated satisfaction with their sex life more positively than they did at BM, and they experienced less discomfort from their complaints. The overall rating was positive, with a mean report grade of 7.3 (SD 1.45; on a 10-point scale). Anonymity, clear information and explanation, and practical exercises are indicated as strengths of the WSTPs, leading to more understanding and normalization. Nurses appreciate the high quality of information and accessibility of the WSTPs. They consider them as a valuable addition to the consultation hours.

Conclusions

WSTPs can reach a large number of young people with sexual problems who are less likely to seek professional help. This can result in an improved understanding of their issues, a decrease in complaints, and reduced barriers to communicating with a partner or professional.
HIV and Black People in Canada: Protocol for a Scoping Review
Authors: Graham Tatyana , Nyambi Agatha , Barkhad Aisha , Stevens-Uninsky Maya , Rehman Nadia , Bhatnagar Neera , Mbuagbaw Lawrence
Published: August 2023

Background

Race-based health information is necessary to address disproportionate barriers racial communities face and to achieve optimal health outcomes. In Canada, Black people are disproportionately affected by HIV. There is an emerging body of literature on this topic, but a concise summary is lacking. There is a need to collectively and critically analyze research on HIV in the Black population in Canada to identify knowledge gaps and address this disproportionate burden.

Objective

The aim of this scoping review is to summarize the evidence on HIV and Black people in Canada. The main outcomes of interest are HIV prevalence, access to care, HIV prevention and treatment, the HIV care cascade, and related HIV outcomes. Through this scoping review, we aim to provide a comprehensive overview of the existing literature and highlight topics that need more investigation in future research.

Methods

We will conduct a scoping review of electronic databases using a systematic search strategy for qualitative, quantitative, or mixed methods studies reporting on HIV and Black people in Canada. We will conduct our searches in MEDLINE, Embase, CINAHL, Web of Science, EBSCO, and Google Scholar for literature published between 1985 and 2023. Gray literature, including government reports, dissertations, and other reports, will be included. Search results will be screened, and the full text of relevant literature will be retrieved. The extraction of data will be conducted independently by 2 reviewers. Consensus meetings will be held to resolve conflicts. Our results will be reported according to the PRISMA-ScR (Preferred Reporting Items for the Systematic Reviews and Meta-Analyses Extension for Scoping Reviews).

Results

The initial title and abstract review identified 447 articles. These articles will be critically appraised, and relevant information will be extracted. Information from these articles will be compared using charts and tables. Screening will start in November 2023, and we anticipate publishing the scoping review in June 2024.

Conclusions

The findings from this scoping review will help inform policy, practice, and research on HIV and Black people in Canada.

International Registered Report Identifier (IRRID)

PRR1-10.2196/49066