bluuebunny/crossref_metadata_2025 huggingface dataset:
Complete Genome Sequence of Enteroinvasive Escherichia coli O96:H19 Associated with a Severe Foodborne Outbreak
Authors: Pettengill Emily A. , Hoffmann Maria , Binet Rachel , Roberts Richard J. , Payne Justin , Allard Marc , Michelacci Valeria , Minelli Fabio , Morabito Stefano
Published: August 2015

We present here the complete genome sequence of a strain of enteroinvasive
Escherichia coli
O96:H19 from a severe foodborne outbreak in a canteen in Italy in 2014. The complete genome may provide important information about the acquired pathogenicity of this strain and the transition between commensal and pathogenic
E. coli
.
HMGA1 overexpression is associated with a particular subset of human breast carcinomas
Authors: Sepe Romina , Piscuoglio Salvatore , Quintavalle Cristina , Perrina Valeria , Quagliata Luca , Formisano Umberto , Terracciano Luigi Maria , Fusco Alfredo , Pallante Pierlorenzo
Published: August 2015

Objectives

Breast cancer represents the second leading cause of cancer mortality among American women and accounts for more than 40 000 deaths annually. High-mobility group A1 (HMGA1) expression has been implicated in the pathogenesis and progression of human malignant tumours, including breast carcinomas. The aim of this study was to evaluate HMGA1 detection as an indicator for the diagnosis and prognosis of human breast carcinoma.

Methods

HMGA1 expression has been analysed by immunohistochemistry in a large series of breast carcinoma resections (1338) combined on a tissue microarray mainly including the ductal carcinoma variant. The results were then correlated with clinicopathological parameters of patients.

Results

HMGA1 overexpression was found in the large majority of breast carcinoma samples and its overexpression positively correlated withHER-2/neuamplification and progesterone receptor, while a negative correlation was found with oestrogen receptor. Conversely, no HMGA1 expression was found in normal breast tissues.

Conclusions

The data reported here indicate that HMGA1 is overexpressed in human breast carcinomas and its levels are associated with a particular endocrine status.
Moutan cortex extract exerts protective effects in a rat model of cardiac ischemia/reperfusion
Authors: Dan Hong , Zhang Liping , Qin Xiaolin , Peng Xiaohui , Wong Mingyan , Tan Xuan , Yu Shanggong , Fang Nianbai
Published: August 2015

Moutan cortex (MC) is a traditional Chinese medicine with diverse biological effects. The present study was performed to investigate the effects of MC on myocardial ischemia/reperfusion (I/R) in rats and to explore its possible mechanisms. Sprague-Dawley rats were administered MC extract (1.98 g/kg, i.g.) for 14 days and underwent a subsequent open-chest procedure involving 30 min of myocardial ischemia and 60 min of reperfusion. The cardioprotective effect of MC was demonstrated by reduced infarct size and marked improvement in the histopathological examination. The increase in the activity of superoxide dismutase (SOD) and glutathione (GSH) as well as the reduction of malondialdehyde (MDA) indicated that MC effectively promoted the anti-oxidative defense system. Increased anti-oxidative defense was accompanied by decreased release of lactate dehydrogenase (LDH) and creatine kinase (CK). The reduction in TUNEL-positive myocytes demonstrated that MC decreased myocardial apoptosis. The mRNA expression of B cell leukemia-2 (Bcl-2) was upregulated by MC and the ratio of Bcl-2/Bcl-2-associated X protein (Bax) mRNA expression was increased. MC pretreatment decreased the mRNA expression of inducible nitric oxide synthase (iNOS). The data from this study suggest that MC exerted protective effects on acute myocardial I/R injury via anti-oxidative and anti-apoptotic activities.
Autotuning algorithmic choice for input sensitivity
Authors: Ding Yufei , Ansel Jason , Veeramachaneni Kalyan , Shen Xipeng , O’Reilly Una-May , Amarasinghe Saman
Published: August 2015

A daunting challenge faced by program performance autotuning is input sensitivity, where the best autotuned configuration may vary with different input sets. This paper presents a novel two-level input learning algorithm to tackle the challenge for an important class of autotuning problems, algorithmic autotuning. The new approach uses a two-level input clustering method to automatically refine input grouping, feature selection, and classifier construction. Its design solves a series of open issues that are particularly essential to algorithmic autotuning, including the enormous optimization space, complex influence by deep input features, high cost in feature extraction, and variable accuracy of algorithmic choices. Experimental results show that the new solution yields up to a 3x speedup over using a single configuration for all inputs, and a 34x speedup over a traditional one-level method for addressing input sensitivity in program optimizations.
A simpler, safer programming and execution model for intermittent systems
Authors: Lucia Brandon , Ransford Benjamin
Published: August 2015

Energy harvesting enables novel devices and applications without batteries, but intermittent operation under energy harvesting poses new challenges to memory consistency that threaten to leave applications in failed states not reachable in continuous execution. This paper presents analytical models that aid in reasoning about intermittence. Using these, we develop DINO (Death Is Not an Option), a programming and execution model that simplifies programming for intermittent systems and ensures volatile and nonvolatile data consistency despite near-constant interruptions. DINO is the first system to address these consistency problems in the context of intermittent execution. We evaluate DINO on three energy-harvesting hardware platforms running different applications. The applications fail and exhibit error without DINO, but run correctly with DINO’s modest 1.8–2.7× run-time overhead. DINO also dramatically simplifies programming, reducing the set of possible failure- related control transfers by 5–9×.
Efficient synthesis of network updates
Authors: McClurg Jedidiah , Hojjat Hossein , Černý Pavol , Foster Nate
Published: August 2015

Software-defined networking (SDN) is revolutionizing the networking industry, but current SDN programming platforms do not provide automated mechanisms for updating global configurations on the fly. Implementing updates by hand is challenging for SDN programmers because networks are distributed systems with hundreds or thousands of interacting nodes. Even if initial and final configurations are correct, naively updating individual nodes can lead to incorrect transient behaviors, including loops, black holes, and access control violations. This paper presents an approach for automatically synthesizing updates that are guaranteed to preserve specified properties. We formalize network updates as a distributed programming problem and develop a synthesis algorithm based on counterexample-guided search and incremental model checking. We describe a prototype implementation, and present results from experiments on real-world topologies and properties demonstrating that our tool scales to updates involving over one-thousand nodes.
Many-core compiler fuzzing
Authors: Lidbury Christopher , Lascu Andrei , Chong Nathan , Donaldson Alastair F.
Published: August 2015

We address the compiler correctness problem for many-core systems through novel applications of fuzz testing to OpenCL compilers. Focusing on two methods from prior work, random differential testing and testing via equivalence modulo inputs (EMI), we present several strategies for random generation of deterministic, communicating OpenCL kernels, and an injection mechanism that allows EMI testing to be applied to kernels that otherwise exhibit little or no dynamically-dead code. We use these methods to conduct a large, controlled testing campaign with respect to 21 OpenCL (device, compiler) configurations, covering a range of CPU, GPU, accelerator, FPGA and emulator implementations. Our study provides independent validation of claims in prior work related to the effectiveness of random differential testing and EMI testing, proposes novel methods for lifting these techniques to the many-core setting and reveals a significant number of OpenCL compiler bugs in commercial implementations.
KJS: a complete formal semantics of JavaScript
Authors: Park Daejun , Stefănescu Andrei , Roşu Grigore
Published: August 2015

This paper presents KJS, the most complete and throughly tested formal semantics of JavaScript to date. Being executable, KJS has been tested against the ECMAScript 5.1 conformance test suite, and passes all 2,782 core language tests. Among the existing implementations of JavaScript, only Chrome V8's passes all the tests, and no other semantics passes more than 90%. In addition to a reference implementation for JavaScript, KJS also yields a simple coverage metric for a test suite: the set of semantic rules it exercises. Our semantics revealed that the ECMAScript 5.1 conformance test suite fails to cover several semantic rules. Guided by the semantics, we wrote tests to exercise those rules. The new tests revealed bugs both in production JavaScript engines (Chrome V8, Safari WebKit, Firefox SpiderMonkey) and in other semantics. KJS is symbolically executable, thus it can be used for formal analysis and verification of JavaScript programs. We verified non-trivial programs and found a known security vulnerability.
Efficient execution of recursive programs on commodity vector hardware
Authors: Ren Bin , Jo Youngjoon , Krishnamoorthy Sriram , Agrawal Kunal , Kulkarni Milind
Published: August 2015

The pursuit of computational efficiency has led to the proliferation of throughput-oriented hardware, from GPUs to increasingly wide vector units on commodity processors and accelerators. This hardware is designed to efficiently execute data-parallel computations in a vectorized manner. However, many algorithms are more naturally expressed as divide-and-conquer, recursive, task-parallel computations. In the absence of data parallelism, it seems that such algorithms are not well suited to throughput-oriented architectures. This paper presents a set of novel code transformations that expose the data parallelism latent in recursive, task-parallel programs. These transformations facilitate straightforward vectorization of task-parallel programs on commodity hardware. We also present scheduling policies that maintain high utilization of vector resources while limiting space usage. Across several task-parallel benchmarks, we demonstrate both efficient vector resource utilization and substantial speedup on chips using Intel’s SSE4.2 vector units, as well as accelerators using Intel’s AVX512 units.
Diagnosing type errors with class
Authors: Zhang Danfeng , Myers Andrew C. , Vytiniotis Dimitrios , Peyton-Jones Simon
Published: August 2015

Type inference engines often give terrible error messages, and the more sophisticated the type system the worse the problem. We show that even with the highly expressive type system implemented by the Glasgow Haskell Compiler (GHC)--including type classes, GADTs, and type families--it is possible to identify the most likely source of the type error, rather than the first source that the inference engine trips over. To determine which are the likely error sources, we apply a simple Bayesian model to a graph representation of the typing constraints; the satisfiability or unsatisfiability of paths within the graph provides evidence for or against possible explanations. While we build on prior work on error diagnosis for simpler type systems, inference in the richer type system of Haskell requires extending the graph with new nodes. The augmentation of the graph creates challenges both for Bayesian reasoning and for ensuring termination. Using a large corpus of Haskell programs, we show that this error localization technique is practical and significantly improves accuracy over the state of the art.
Alagebrium inhibits neointimal hyperplasia and restores distributions of wall shear stress by reducing downstream vascular resistance in obese and diabetic rats
Authors: Wang Hongfeng , Weihrauch Dorothee , Kersten Judy R. , Toth Jeffrey M. , Passerini Anthony G. , Rajamani Anita , Schrepfer Sonja , LaDisa John F.
Published: August 2015

Mechanisms of restenosis in type 2 diabetes mellitus (T2DM) are incompletely elucidated, but advanced glycation end-product (AGE)-induced vascular remodeling likely contributes. We tested the hypothesis that AGE-related collagen cross-linking (ARCC) leads to increased downstream vascular resistance and altered in-stent hemodynamics, thereby promoting neointimal hyperplasia (NH) in T2DM. We proposed that decreasing ARCC with ALT-711 (Alagebrium) would mitigate this response. Abdominal aortic stents were implanted in Zucker lean (ZL), obese (ZO), and diabetic (ZD) rats. Blood flow, vessel diameter, and wall shear stress (WSS) were calculated after 21 days, and NH was quantified. Arterial segments (aorta, carotid, iliac, femoral, and arterioles) were harvested to detect ARCC and protein expression, including transforming growth factor-β (TGF-β) and receptor for AGEs (RAGE). Downstream resistance was elevated (60%), whereas flow and WSS were significantly decreased (44% and 56%) in ZD vs. ZL rats. NH was increased in ZO but not ZD rats. ALT-711 reduced ARCC and resistance (46%) in ZD rats while decreasing NH and producing similar in-stent WSS across groups. No consistent differences in RAGE or TGF-β expression were observed in arterial segments. ALT-711 modified lectin-type oxidized LDL receptor 1 but not RAGE expression by cells on decellularized matrices. In conclusion, ALT-711 decreased ARCC, increased in-stent flow rate, and reduced NH in ZO and ZD rats through RAGE-independent pathways. The study supports an important role for AGE-induced remodeling within and downstream of stent implantation to promote enhanced NH in T2DM.
Aerobic training normalizes autonomic dysfunction, HMGB1 content, microglia activation and inflammation in hypothalamic paraventricular nucleus of SHR
Authors: Masson Gustavo Santos , Nair Anand R. , Silva Soares Pedro Paulo , Michelini Lisete Compagno , Francis Joseph
Published: August 2015

Exercise training (ExT) is recommended to treat hypertension along with pharmaceutical antihypertensive therapies. Effects of ExT in hypothalamic content of high mobility box 1 (HMGB1) and microglial activation remain unknown. We examined whether ExT would decrease autonomic and cardiovascular abnormalities in spontaneously hypertensive rats (SHR), and whether these effects were associated with decreased HMGB1 content, microglial activation, and inflammation in the hypothalamic paraventricular nucleus (PVN). Normotensive Wistar-Kyoto (WKY) rats and SHR underwent moderate-intensity ExT for 2 wk. After ExT, cardiovascular (heart rate and arterial pressure) and autonomic parameters (arterial pressure and heart rate variability, peripheral sympathetic activity, cardiac vagal activity, and baroreflex function) were measured in conscious and freely-moving rats through chronic arterial and venous catheterization. Cerebrospinal fluid, plasma, and brain were collected for molecular and immunohistochemistry analyses of the PVN. In addition to reduced heart rate variability, decreased vagal cardiac activity and increased mean arterial pressure, heart rate, arterial pressure variability, cardiac, and vasomotor sympathetic activity, SHR had higher HMGB1 protein expression, IκB-α phosphorylation, TNF-α and IL-6 protein expression, and microglia activation in the PVN. These changes were accompanied by higher plasma and cerebrospinal fluid levels of HMGB1. The ExT + SHR group had decreased expression of HMGB1, CXCR4, SDF-1, and phosphorylation of p42/44 and IκB-α. ExT reduced microglial activation and proinflammatory cytokines content in the PVN, and improved autonomic control as well. Data suggest that training-induced downregulation of activated HMGB1/CXCR4/microglia/proinflammatory cytokines axis in the PVN of SHR is a prompt neural adaptation to counterbalance the deleterious effects of inflammation on autonomic control.
Effect of carbohydrate feeding on the bone metabolic response to running
Authors: Sale Craig , Varley Ian , Jones Thomas W. , James Ruth M. , Tang Jonathan C. Y. , Fraser William D. , Greeves Julie P.
Published: August 2015

Bone resorption is increased after running, with no change in bone formation. Feeding during exercise might attenuate this increase, preventing associated problems for bone. This study investigated the immediate and short-term bone metabolic responses to carbohydrate (CHO) feeding during treadmill running. Ten men completed two 7-day trials, once being fed CHO (8% glucose immediately before, every 20 min during, and immediately after exercise at a rate of 0.7 g CHO·kg body mass−1·h−1) and once being fed placebo (PBO). On day 4 of each trial, participants completed a 120-min treadmill run at 70% of maximal oxygen consumption (V̇o2 max). Blood was taken at baseline (BASE), immediately after exercise (EE), after 60 (R1) and 120 (R2) min of recovery, and on three follow-up days (FU1-FU3). Markers of bone resorption [COOH-terminal telopeptide region of collagen type 1 (β-CTX)] and formation [NH2-terminal propeptides of procollagen type 1 (P1NP)] were measured, along with osteocalcin (OC), parathyroid hormone (PTH), albumin-adjusted calcium (ACa), phosphate, glucagon-like peptide-2 (GLP-2), interleukin-6 (IL-6), insulin, cortisol, leptin, and osteoprotogerin (OPG). Area under the curve was calculated in terms of the immediate (BASE, EE, R1, and R2) and short-term (BASE, FU1, FU2, and FU3) responses to exercise. β-CTX, P1NP, and IL-6 responses to exercise were significantly lower in the immediate postexercise period with CHO feeding compared with PBO (β-CTX: P = 0.028; P1NP: P = 0.021; IL-6: P = 0.036), although there was no difference in the short-term response (β-CTX: P = 0.856; P1NP: P = 0.721; IL-6: P = 0.327). No other variable was significantly affected by CHO feeding during exercise. We conclude that CHO feeding during exercise attenuated the β-CTX and P1NP responses in the hours but not days following exercise, indicating an acute effect of CHO feeding on bone turnover.
In vivo assessment of contractile strength distinguishes differential gene function in skeletal muscle of zebrafish larvae
Authors: Martin Brit L. , Gallagher Thomas L. , Rastogi Neha , Davis Jonathan P. , Beattie Christine E. , Amacher Sharon L. , Janssen Paul M. L.
Published: August 2015

The accessible genetics and extensive skeletal musculature of the zebrafish make it a versatile and increasingly used model for studying muscle contraction. We here describe the development of an in vivo assay for measuring the contractile force of intact zebrafish at the larval stage. In addition, as proof of applicability, we have used this assay to quantify contractile strength of zebrafish larvae in a morphant model of deranged rbfox function. Average maximum tetanic (180 Hz) whole body forces produced by wild-type larvae at 2, 3, 4, and 5 days postfertilization amounted to 3.0, 7.2, 9.1, and 10.8 mN, respectively. To compare at potentially different stages of muscle development, we developed an immunohistological assay for empirically determining the cross-sectional area of larval trunk skeletal muscle to quantify muscle-specific force per cross-sectional area. At 4-5 days postfertilization, specific force amounts to ∼300 mN/mm2, which is similar to fully developed adult mammalian skeletal muscle. We used these assays to measure contractile strength in zebrafish singly or doubly deficient for two rbfox paralogs, rbfox1l and rbfox2, which encode RNA-binding factors shown previously to modulate muscle function and muscle-specific splicing. We found rbfox2 morphants produce maximal tetanic forces similar to wild-type larvae, whereas rbfox1l morphants demonstrate significantly impaired function. rbfox1l/rbfox2 morphants are paralyzed, and their lack of contractile force production in our assay suggests that paralysis is a muscle-autonomous defect. These quantitative functional results allow measurement of muscle-specific phenotypes independent of neural input.
miR-200c Targets CDK2 and Suppresses Tumorigenesis in Renal Cell Carcinoma
Authors: Wang Xuegang , Chen Xuanyu , Han Weiwei , Ruan Anming , Chen Li , Wang Rong , Xu Zhenghong , Xiao Pei , Lu Xing , Zhao Yan , Zhou Jia , Chen Shaoyong , Du Quansheng , Yang Hongmei , Zhang Xiaoping
Published: August 2015

miRNA expression profiles are widely investigated in the major cancers, but their specific roles and functions in cancers have not yet to be fully elucidated. In this study, miRNA expression profiles were determined in clear cell renal cell carcinomas (ccRCC) and in matched normal kidney tissues by using a miRNA microarray platform which covers a total of 851 human miRNAs. Differential expression of 74 miRNAs were identified between ccRCC specimens and their matched adjacent noncancerous tissues, of which 30 were significantly upregulated in ccRCCs, and the other 44 were downregulated (fold change ≥ 2, P < 0.05). Interestingly, miR-200c was commonly downregulated in ccRCC specimens and ccRCC cell lines with significant functional consequences. Growth curve and FACS assay indicated that overexpression of miR-200c suppressed cell growth and induced cell-cycle arrest at G0–G1 phases in SN12-PM6 and 786-O cells. Furthermore, miR-200c could suppress in vivo tumor growth of SN12-PM6 cells in mice. Bioinformatics exposed cyclin-dependent kinase 2 (CDK2) as a potential target of miR-200c, which was validated using a luciferase reporter assay. Mechanistic investigations revealed that miR-200c was directly responsible for suppressing the expression of CDK2 in ccRCC cell lines and xenografts. Taken together, miR-200c plays an antioncogenic role in ccRCC, through controlling cell growth and cell-cycle progression by downregulating the G1–S regulator CDK2.

Implications: miR-200c exerts its novel antioncogenic function in renal cell carcinoma by controlling CDK2-dependent cell growth and cell-cycle progression. Mol Cancer Res; 13(12); 1567–77. ©2015 AACR.
Tumor-Derived Cell Lines as Molecular Models of Cancer Pharmacogenomics
Authors: Goodspeed Andrew , Heiser Laura M. , Gray Joe W. , Costello James C.
Published: August 2015

Compared with normal cells, tumor cells have undergone an array of genetic and epigenetic alterations. Often, these changes underlie cancer development, progression, and drug resistance, so the utility of model systems rests on their ability to recapitulate the genomic aberrations observed in primary tumors. Tumor-derived cell lines have long been used to study the underlying biologic processes in cancer, as well as screening platforms for discovering and evaluating the efficacy of anticancer therapeutics. Multiple -omic measurements across more than a thousand cancer cell lines have been produced following advances in high-throughput technologies and multigroup collaborative projects. These data complement the large, international cancer genomic sequencing efforts to characterize patient tumors, such as The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC). Given the scope and scale of data that have been generated, researchers are now in a position to evaluate the similarities and differences that exist in genomic features between cell lines and patient samples. As pharmacogenomics models, cell lines offer the advantages of being easily grown, relatively inexpensive, and amenable to high-throughput testing of therapeutic agents. Data generated from cell lines can then be used to link cellular drug response to genomic features, where the ultimate goal is to build predictive signatures of patient outcome. This review highlights the recent work that has compared -omic profiles of cell lines with primary tumors, and discusses the advantages and disadvantages of cancer cell lines as pharmacogenomic models of anticancer therapies. Mol Cancer Res; 14(1); 3–13. ©2015 AACR.
O sentido moderno da administração colonial: o caso do Regimento das Missões
Authors: Oliveira Pedro Rocha de
Published: August 2015

Através da análise dos Regimentos de 1548 e 1686, procuramos sublinhar e discutir o conteúdo histórico-social moderno do esforço colonial no Brasil. Identificamos a centralidade da preocupação com a criação de uma população de trabalhadores a partir dos indígenas e examinamos o caráter legal que tal problema assume para a administração metropolitana, mostrando como a especificidade da violência colonial diz respeito à expansão e sofisticação de instituições capitalistas típicas.
Duration of Heart Failure Is an Important Predictor of Outcomes After Mechanical Circulatory Support
Authors: Loyaga-Rendon Renzo Y. , Acharya Deepak , Pamboukian Salpy V. , Tallaj Jose A. , Cantor Ryan , Starling Randall C. , Naftel David C. , Kirklin James K.
Published: August 2015

Background—

Heart failure (HF) progression results in worsening functional capacity and end-organ compromise. HF may occur acutely or be associated with a chronic presentation. We hypothesized that the duration of HF affects outcomes after mechanical circulatory support.

Methods and Results—

A total of 10 730 patients registered in Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) who received primary implant of a mechanical circulatory support device were stratified according to the duration of HF symptoms: acute HF (AHF; ≤1 month), sub-AHF (1–12 months), and chronic HF (Cr-HF; ≥ 12 months). AHF patients were younger with a higher proportion of women and white and with a lower prevalence of peripheral vascular disease and history of prior cardiac surgeries. Sixty percent of AHF patients were INTERMACS profile 1 at the time of implantation versus 24% and 13.2% in the sub-AHF and Cr-HF groups, respectively (
P
=0.0001). Patients with AHF had the highest utilization of biventricular support (14.4%). The estimated survival at 4 years was 58%, 51%, and 45% for the AHF, sub-AHF, and Cr-HF patients (
P
=0.006). The proportion of patients with AHF who received heart transplantation at 1 year was 29% compared with 22.6% in the patients with Cr-HF. After adjustment for known risk factors of adverse outcome, patients with AHF have a better late phase prognosis compared with patients with Cr-HF (hazard ratio, 0.34;
P
=0.0003).

Conclusions—

The duration of HF before durable mechanical circulatory support implant is an important variable influencing outcome. Patients with AHF had improved survival at 4 years and higher rates of transplantation at 1 year despite higher acuity of presentation.
Cavernous Sinus Thrombosis in Children
Authors: Press Craig A. , Lindsay Aaron , Stence Nicholas V. , Fenton Laura Z. , Bernard Timothy J. , Mirsky David M.
Published: August 2015

Background and Purpose—

Cavernous sinus thrombosis (CST) is a rare life-threatening cerebrovascular disease known to cause carotid artery narrowing (CAN) and arterial ischemic stroke. The imaging features of CST and related complications have been reported in adults, but rarely in children.

Methods—

We performed a retrospective review of children with imaging confirmed CST from 2003 to 2014, describing presenting symptoms, imaging findings, and treatment.

Results—

Ten patients with CST were identified. All had CAN and 6 of 10 developed infarcts. Of 8 patients treated with anticoagulation therapy, 3 developed new infarcts. None required discontinuation of anticoagulation therapy because of bleeding. Visual impairment secondary to infectious neuritis was common. Imaging characteristics include cavernous sinus expansion, filling defects, restricted diffusion, arterial wall enhancement, empyema, superior ophthalmic vein enlargement and thrombosis, orbital cellulitis, and pituitary inflammation. CAN resolved in 60% of cases. Outcomes were mostly good, with a modified Rankin Scale score of ≤1 for 7 of 10 patients at discharge and 1 death.

Conclusions—

CAN and infarcts were common in this modest cohort of children with CST. Despite the high incidence of CAN and infarction, outcomes were often favorable. Although this is the largest cohort of childhood CST reported to date, large multicenter cohorts are needed to confirm our findings and determine the preferred therapeutic strategies for childhood CST.
Intracranial Carotid Calcification on Cranial Computed Tomography
Authors: Subedi Deepak , Zishan Umme Sara , Chappell Francesca , Gregoriades Maria-Lena , Sudlow Cathie , Sellar Robin , Wardlaw Joanna
Published: August 2015

Background and Purpose—

Intracranial internal carotid artery calcification is associated with cerebrovascular risk factors and stroke, but few quantification methods are available. We tested the reliability of visual scoring, semiautomated Agatston score, and calcium volume measurement in patients with recent stroke.

Methods—

We used scans from a prospective hospital stroke registry and included patients with anterior circulation ischemic stroke or transient ischemic stroke whose noncontrast cranial computed tomographic scans were available electronically. Two raters measured semiautomatic quantitative Agatston score, and calcium volume, and performed qualitative visual scoring using the original 4-point Woodcock score and a modified Woodcock score, where each image on which the internal carotid arteries appeared was scored and the slice scores summed.

Results—

Intra- and interobserver coefficient of variations were 8.8% and 16.5% for Agatston, 8.8% and 15.5% for calcium volume, and 5.7% and 5.4% for the modified Woodcock visual score, respectively. The modified Woodcock visual score correlated strongly with both Agatston and calcium volume quantitative measures (both
R
2
=0.84;
P
<0.0001); calcium volume increased by 0.47-mm/point increase in modified Woodcock visual score. Intracranial internal carotid artery calcification increased with age by all measures (eg, visual score, Spearman ρ=0.4;
P
=0.005).

Conclusions—

Visual scores correlate highly with quantitative intracranial internal carotid artery calcification measures, with excellent observer agreements. Visual intracranial internal carotid artery scores could be a rapid and practical method for epidemiological studies.
Safety and Tolerability of Desmoteplase Within 3 to 9 Hours After Symptoms Onset in Japanese Patients With Ischemic Stroke
Authors: Mori Etsuro , Minematsu Kazuo , Nakagawara Jyoji , Hasegawa Yasuhiro , Nagahiro Shinji , Okada Yasushi , Truelsen Thomas , Lindsten Annika , Ogawa Akira , Yamaguchi Takenori
Published: August 2015

Background and Purpose—

This study investigated the safety and tolerability of desmoteplase administered within 3 to 9 hours after stroke symptoms onset in Japanese patients with acute ischemic stroke.

Methods—

Patients were randomized to treatment with either desmoteplase or placebo in a 2:1 ratio in 2 consecutive cohorts (70 μg/kg and then 90 μg/kg). Included patients had a baseline National Institutes of Health Stroke Scale score of 4 to 24 and occlusion or high-grade stenosis in the middle cerebral artery segment M1 or M2 on magnetic resonance angiography. The incidence of symptomatic intracranial hemorrhage (≤72 hours) was defined as the primary end point. The occurrence of asymptomatic ICH, symptomatic cerebral edemas, and adverse events were other safety outcomes of special interest.

Results—

Symptomatic intracranial hemorrhage was observed within 72 hours in 2 patients treated with placebo and in 1 patient treated with 70 μg/kg desmoteplase. Any ICH (symptomatic or asymptomatic ICH) within 72 hours were observed in 7 (43.8%) patients treated with placebo, in 8 (50%) patients treated with 70 μg/kg desmoteplase, and in 9 (56.3%) patients treated with 90 μg/kg desmoteplase. Desmoteplase treatment with 70 or 90 μg/kg was not associated with an increased risk of symptomatic cerebral edema compared with placebo. There were no other serious safety concerns associated with desmoteplase.

Conclusions—

Desmoteplase in both 70 and 90 μg/kg doses had a favorable safety profile and was well tolerated in Japanese patients with acute ischemic stroke when administered 3 to 9 hours after stroke symptoms onset.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01104467.
The Tatmadaw Legacy and Beyond
Authors: Armao Fabio
Published: August 2015

The ongoing democratisation process in Myanmar represents one of the most relevant ‘stress tests’ for the democratic transition theory. This theory actually considers stateness as a prerequisite for democracy; and, consequently, concentrates mainly on the mode of progression of the state from dictatorship to representative government. We assume, on the contrary, that, particularly after 1989, the very idea of stateness is being questioned more and more (and not only in developing countries). This paper does not intend to add original data relative to Myanmar’s recent history. It rather aims to shed some new light on Myanmar’s democratisation process, approaching the issue as a specific case-study of democratic transition affected by clustered sovereignty. The introduction will attempt to explain the main methodological prerequisites of the paper. The article will then analyse the three main risk factors affecting the democratisation process in Myanmar: (1) the (in)ability to neutralise the autonomous centres of power equipped with means of coercion and return them to a shared political sphere; (2) the (in)ability to integrate different intra-group networks in the shared political sphere; (3) the (in)ability to eliminate or at least reduce the social inequalities, detaching them from the shared political sphere.
Epimedium tianmenshanensis (Berberidaceae), a new species from central China
Authors: Zhang Dai-Gui , Deng Tao , King Changkyun , Zhang Jianwen , Nie Zelong , Sun Hang
Published: August 2015

A distinctive, previously undescribed species of Epimedium (Berberidaceae), which we propose naming E. tianmenshanensis, was found during a floristic survey in Hunan, China. It is similar to E. baojingense and E. franchetii, but has smaller flowers and petals with a short, blunt spur. We determined the phylogenetic position of the new species using DNA sequences of nuclear ITS and two chloroplast regions (atpB-rbcL intergenic spacer and matK). Molecular evidence indicates that E. tianmenshanensis occupies a distinct group related to E. baojingense.
The genus Loimia Malmgren, 1866 (Annelida: Terebellidae) off the Brazilian coast, with description of three new species and notes on some morphological characters of the genus
Authors: CARRERETTE ORLEMIR , NOGUEIRA JOÃO MIGUEL DE MATOS
Published: August 2015

Three new species of Loimia were collected along the Brazilian coast, during some independent projects, from shallow  to deep waters off the continental slope. These species are L. megaoculata sp. nov., L. armata sp. nov., and L. brasiliensis sp. nov., all herein described and compared with the morphologically most similar congeners. Loimia megaoculata sp. nov., is characterized by having large, dark eyespots, progressively smaller from dorso-laterally towards lateral basal part of prostomium; lobes of segment 1 are distally rounded, roughly circular, barely reaching mid-length of upper lip; uncini have up to 6–7 teeth, including basal-most tooth. Loimia armata sp. nov., lacks eyespots; stout lobes of segment 1 nearly reach level of upper lip; uncini have up to 7–8 teeth, including basal-most tooth. Loimia brasiliensis sp. nov., has two narrow rows of eyespots; lobes of segment 1 are thin, reaching mid-length of upper lip; uncini have 5–6 teeth, including basal-most tooth. We provide a brief discussion on the main morphological characters useful for the taxonomy of this genus, such as presence of eyespots, and morphology of lobes of segments 1 and 3, of mid-ventral pads and neurochaetae. Up to now only two species had been recorded from Brazil, namely L. grubei and L. medusa, both doubtful records, as discussed along this paper.
Description of two new species related to Pterostichus (Aphaonus) arcanoides Lorenz, 1998 from the West Transcaucasia (Coleoptera: Carabidae: Pterostichini)
Authors: ZAMOTAJLOV ALEXANDR S. , SOLODOVNIKOV IGOR A. , FOMINYKH DMITRIY D.
Published: August 2015

Two new carabid beetle species, Pterostichus (Aphaonus) mariamae sp. nov. and Pterostichus (Aphaonus) svetlanae sp. nov., related to an enigmatic mountainous representative of the subgenus Aphaonus, P. (Aphaonus) arcanoides Lorenz, 1998, are described from the Abkhazian midlands (Tsebelda Plateau and Mtsara district). Discriminative features of the new species in the subgenus are briefly discussed.
Three new species of Megaselia Rondani (Diptera, Phoridae) from mailand China
Authors: FANG HONG , LIU GUANGCHUN
Published: August 2015

Three new species, Megaselia cornipalpis sp. nov., M. lacunitarsalis sp. nov. and M. trimacula sp. nov. are described and illustrated from mainland China. A checklist of species of genus Megaselia recorded from mainland China is provided.
Meridional Overturning Circulations Driven by Surface Wind and Buoyancy Forcing
Authors: Bell Michael J.
Published: August 2015

The meridional overturning circulation (MOC) can be considered to consist of a downwelling limb in the Northern Hemisphere (NH) and an upwelling limb in the Southern Hemisphere (SH) that are connected via western boundary currents. Steady-state analytical gyre-scale solutions of the planetary geostrophic equations are derived for a downwelling limb driven in the NH solely by surface heat loss. In these solutions the rates of the water mass transformations between layers driven by the surface heat loss determine the strength of the downwelling limb. Simple expressions are obtained for these transformation rates that depend on the most southerly latitudes where heat loss occurs and the depths of the isopycnals on the eastern boundary. Previously derived expressions for the water mass transformation rates in subpolar gyres driven by the Ekman upwelling characteristic of the SH are also summarized. Explicit expressions for the MOC transport and the depths of isopycnals on the eastern boundary are then derived by equating the water mass transformations in the upwelling and downwelling limbs. The MOC obtained for a “single-basin” two-layer model is shown to be generally consistent with that obtained by Gnanadesikan. The model’s energetics are derived and discussed. In a world without a circumpolar channel in the SH, it is suggested that the upwelling limb would feed downwelling limbs in both hemispheres. In a world with two basins in the NH, if one of them has a strong halocline the model suggests that the MOC would be very weak in that basin.
The impact of snares on the continuity of adolescent-onset antisocial behaviour: A test of Moffitt’s developmental taxonomy
Authors: McGee Tara Renae , Hayatbakhsh Mohammad R , Bor William , Aird Rosemary L , Dean Angela J , Najman Jake M
Published: August 2015

Moffitt’s dual typology of ‘life-course persistent’ and ‘adolescence limited’ offending has received extensive empirical attention, but the extent to which the antisocial behaviour of adolescence limited offenders is constrained to adolescence is relatively under-examined. Using data from the Australian Mater University Study of Pregnancy and its Outcomes, we explore Moffitt’s concept of snares, or those factors that may lead to an adolescent persisting in antisocial behaviour such as drug addiction, educational failure, and contact with the justice system. The Mater University Study of Pregnancy and its Outcomes is a longitudinal study of mother–child dyads from the pre-natal stage to 21 years of age. Findings show that one-third of individuals identified as having an adolescent onset of antisocial behaviour persisted with this antisocial behaviour as young adults. This continuity can, in part, be explained by snares and the research suggests that reducing exposure to snares may lead to less antisocial behaviour in adulthood.
“Where’s home, Ulysses?” Judith Wright in Europe 1937
Authors: Kennedy Sarah
Published: August 2015

When Judith Wright travelled to Europe in the “loaded spring” of February 1937, the 22-year-old poet found herself witness to “a break in the consciousness of Europe”. This article argues that Wright’s experience of being an outsider in Europe at this crucial historical moment had profound implications for her poetics, in the form of a compound and productive series of displacements. Her peripatetic encounters with European cultures-in-crisis caused Wright to despair of Europe as a source of political and creative renewal, and exposed fault lines in her own cultural orientation. Sundered from her Anglophile cultural inheritance, and able to reflect on home with the distance and imaginative ambivalence of an outsider, Wright invoked Ulysses — that archetypal poetic wanderer — whose experience of archipelagic journeying came to express for her the contingencies and hauntedness of Australia’s palimpsestic identity. This essay positions the shifting perspectives and excursive patterns of Wright’s developing poetics in relation to concepts of outsideness and embodiment, drawing on the work of Mikhail Bakhtin and phenomenological philosophies of mind.
A comprehensive study on the thermo-mechanical properties of multi-walled carbon nanotube/epoxy nanocomposites
Authors: Yas Mohammad H , Mohammadi Samira , Astinchap Bandar , Heshmati Mahmood
Published: August 2015

In this study, the mechanical, thermal and viscoelastic properties of multi-walled carbon nanotube/epoxy nanocomposite at low-weight percentages of nanotubes are evaluated and discussed. In order to provide better interfacial interactions of constituent materials, the multi-walled carbon nanotubes are functionalized with combination of H2SO4/HNO3. Dynamic-mechanical thermal analysis test and hot plate thermal conductivity are performed to characterize temperature-dependent mechanical and thermal properties. Our results indicate that applying low weight fractions of functionalized multi-walled carbon nanotubes can effectively improve the elastic storage modulus (∼47%) and thermal conductivity (∼36%) as a function of temperature. All steps and characterization are described in detail. For higher concentration of multi-walled carbon nanotubes, SEM characterization of the fracture surfaces of the samples reveals that agglomeration of the nanotubes is the main reason for degradation of the properties. Moreover, based on experimental data, an elastic model has been presented to predict the obtained temperature-dependent elastic modulus.
Cooperation in Hard Times
Authors: Davis Christina L. , Pelc Krzysztof J.
Published: August 2015

Hard times give rise to greater demand for protection. International trade rules include provisions that allow for raising barriers to aid industries when they suffer economic injury. Yet widespread use of flexibility measures may undermine the trade system and worsen economic conditions. How do states balance these conflicting pressures? This article assesses the effect of crises on cooperation in trade. We hypothesize that governments impose less protectionism during economic crisis when economic troubles are widespread across countries than when they face crisis in isolation. The lesson of Smoot–Hawley and coordination through international economic institutions represent mechanisms of informal governance that encourage cooperation to avoid a spiral of protectionism. Analysis of industry-level data on protection measures for the period from 1996 to 2011 provides support for our claim that under conditions of shared hard times, states exercise strategic self-restraint to avoid beggar-thy-neighbor policies.
New ASBOs for old?
Authors: Edwards Phil
Published: August 2015

The Anti-Social Behaviour Order (ASBO) was designed as a civil/criminal hybrid, preventive in structure and with a largely undefined object. After 2002, legal challenges to the ASBO led to the use of justificatory arguments from cumulative effect, and to the introduction of new measures which offered to regulate anti-social behaviour in more legally acceptable forms. In 2014 the Coalition government replaced the ASBO with two new instruments: a post-conviction Criminal Behaviour Order (CBO) and a wholly-civil anti-social behaviour injunction (ASB Injunction). While the CBO and the ASB Injunction build on this history, it is argued that they do not represent a new approach to anti-social behaviour so much as a continuation of the ASBO by other means.
Maternal Parenting Style and Delinquency by Race and the Moderating Effect of Structural Disadvantage
Authors: Mowen Thomas J. , Schroeder Ryan D.
Published: August 2015

Contemporary research suggests authoritative parenting is the most effective parenting style in deterring juvenile delinquency. Some research has found there are differences in parenting style between racial groups due to structural disadvantage faced by marginalized individuals. Yet, relatively little is known about how racial differences in parenting and the moderating effect of disadvantage relate to juvenile delinquency. The current project explores parenting style differences among Black, Hispanic, and White mothers and the moderating impact of disadvantage on delinquency. Results indicate authoritarian parenting is least effective in deterring delinquency among all racial groups; however, neighborhood disadvantage provides a negative moderating effect between authoritarian parenting and delinquency for Black youth only, whereas uninvolved parenting was related to delinquency for White youth only.
Milton and the English Auden
Authors: Daniel Clay
Published: August 2015

Unlike many modernists, W. H. Auden consistently esteemed Milton’s poetry. Moreover, he often was stimulated by Milton’s antipathetic cultural legacy, which, in the 1930s, he identified with the rise of the National Socialists. This identification, most clearly made in New Year Letter (1940) and Letter to Lord Byron (1936), also informs one of Auden’s most well-known poems, “Lay Your Sleeping Head, My Love” (sometimes called “Lullaby”) (January 1937). That poem carefully rewrites Milton’s notions of love and religion, especially as they appear in “On Time,” to accord with Auden’s sense of his own time.
Components of effortful control and their relations to children’s shyness
Authors: Eggum-Wilkens Natalie D , Reichenberg Ray E , Eisenberg Nancy , Spinrad Tracy L
Published: August 2015

Relations between children’s ( n = 213) mother-reported effortful control components (attention focusing, attention shifting, inhibitory control at 42 months; activational control at 72 months) and mother-reported shyness trajectories across 42, 54, 72, and 84 months of age were examined. In growth models, shyness decreased. Inhibitory control and attention shifting predicted higher levels and lower levels of shyness at 42 months (the intercept), respectively. Inhibitory control negatively, and attention shifting positively, predicted the shyness slope. Children with higher inhibitory control had relatively more rapid decreases in shyness. Children with higher attention shifting had relatively slower decreases in shyness. Activational control was negatively correlated with the shyness intercept. Effortful control components should be examined separately, rather than in combination, in relation to shyness in the future. If results are replicated, it may suggest that fostering attention shifting and activational control development helps prevent, or maintain low levels of, shyness during childhood.