bluuebunny/crossref_metadata_2025 huggingface dataset:
Establishment of 2.5D organoid culture model using 3D bladder cancer organoid culture
Authors: Abugomaa Amira , Elbadawy Mohamed , Yamanaka Megumi , Goto Yuta , Hayashi Kimika , Mori Takashi , Uchide Tsuyoshi , Azakami Daigo , Fukushima Ryuji , Yoshida Toshinori , Shibutani Makoto , Yamashita Risako , Kobayashi Mio , Yamawaki Hideyuki , Shinohara Yuta , Kaneda Masahiro , Usui Tatsuya , Sasaki Kazuaki
Published: June 2020

Three-dimensional (3D) organoid culture holds great promises in cancer precision medicine. However, Matrigel and stem cell-stimulating supplements are necessary for culturing 3D organoid cells. It costs a lot of money and consumes more time and effort compared with 2D cultured cells. Therefore, the establishment of cheaper and Matrigel-free organoid culture that can maintain the characteristics of a part of 3D organoids is demanded. In the previous study, we established a dog bladder cancer (BC) 3D organoid culture system by using their urine samples. Here, we successfully isolated cells named “2.5D organoid” from multiple strains of dog BC 3D organoids using 2.5 organoid media. The cell proliferation speed of 2.5D organoids was faster than parental 3D organoid cells. The expression pattern of stem cell markers was close to 3D organoids. Injection of 2.5D organoid cells into immunodeficient mice formed tumors and showed the histopathological characteristics of urothelial carcinoma similar to the injection of dog BC 3D organoids. The 2.5D organoids had a similar sensitivity profile for anti-cancer drug treatment to their parental 3D organoids. These data suggest that our established 2.5D organoid culture method might become a reasonable and useful tool instead of 3D organoids in dog BC research and therapy.
Green synthesis of peptide functionalized reduced graphene oxide (rGO) nano bioconjugate with enhanced antibacterial activity
Authors: Joshi Shubhi , Siddiqui Ruby , Sharma Pratibha , Kumar Rajesh , Verma Gaurav , Saini Avneet
Published: June 2020

Bioengineered nanoconjugates have enormous potential as a multifunctional platform for biomedical applications. Conjugation between biotic and abiotic materials enables formulation of nanoconjugates with enhanced physico-chemical properties, increased stability and ability to overcome the inherent shortcomings of individual materials. In this study, we report the preparation and biophysical characterization of an antibacterial system formulated by functionalizing reduced graphene oxide (rGO) with an antimicrobial peptide via covalent as well as non-covalent interaction mechanisms. Environmentally benign synthesis approach was adopted for the formation of rGO, using L-ascorbic acid as a reducing agent. Covalently conjugated peptide-graphitic conjugate displayed improved antibacterial efficacy againstEscherichia coliwith considerably low cytotoxic activity towards erythrocytes in comparison to self-assembled conjugate and rGO alone. The studies described herein are highly significant in the field of biomaterials and aims to open new avenues of research focusing on a plethora of applications as a prospective non-toxic substitute to conventional antibacterial approaches.
Micellization-induced amplified fluorescence response for highly sensitive detection of heparin in serum
Authors: Jang Yeon Jin , Kim Boyun , Roh Euijin , Kim Hyunuk , Lee Seoung Ho
Published: June 2020

Fluorescence-based assays should be feasible in aqueous media for effectively detecting the biological factors. However, numerous sensors have limited signal transductions and low fluorescence quantum yields due to the ingerently reduced excited state energy of fluorophores in aqueous solution, which reduces their sensitivity. This necessitates a smart sensing approach with an amplified fluorescence response for analytes in aqueous solution. Herein, a new building block which self-assembles in aqueous media, giving a micellar sturcuture with the hydrophobic π-extended conjugated system at the core and hydrophilic groups at the periphery, was devised for the first time. We demonstrated that the aggregated fluorophores in a micelle induce amplified fluorescence quenching, in which the excited electron efficiently migrates through π-extended conjugated system in a micelle, as in a polymeric system. Such feature differentiates this sensing approach from the numerous fluorescence-based tools previously developed for sensitive detection. This new system exhibited highly sensitive signal transduction for specific analytes even under actual bioanalytical conditions.
An automated platform to monitor long-term behavior and healthspan in Caenorhabditis elegans under precise environmental control
Authors: Le Kim N. , Zhan Mei , Cho Yongmin , Wan Jason , Patel Dhaval S. , Lu Hang
Published: June 2020

Health and longevity in all organisms are strongly influenced by the environment. To fully understand how environmental factors interact with genetic and stochastic factors to modulate the aging process, it is crucial to precisely control environmental conditions for long-term studies. In the commonly used model organism Caenorhabditis elegans, existing assays for healthspan and lifespan have inherent limitations, making it difficult to perform large-scale longitudinal aging studies under precise environmental control. To address these constraints, we developed the Health and Lifespan Testing Hub (HeALTH), an automated, microfluidic-based system for robust longitudinal behavioral monitoring. Our system provides long-term (i.e. entire lifespan) spatiotemporal environmental control. We demonstrate healthspan and lifespan studies under a variety of genetic and environmental perturbations while observing how individuality plays a role in the aging process. This system is generalizable beyond aging research, particularly for short- or long-term behavioral assays, and could be adapted for other model systems.
Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA
Authors: Peng Haibo , Xie Beibei , Yang Xiaohong , Dai Jiaojiao , Wei Guoxing , He Yun
Published: June 2020

A rationally designed mannosylated amphiphilic pillar[5]arene (Man@AP5) self-assembles into supramolecular vesicles with encapsulated vancomycin (Man@AP5-Van), enhancing vancomycin's antibacterial efficacy against intracellular MRSA.
Formation of quaternary carbons through cobalt-catalyzed C(sp3)–C(sp3) Negishi cross-coupling
Authors: Palao Eduardo , López Enol , Torres-Moya Iván , de la Hoz Antonio , Díaz-Ortiz Ángel , Alcázar Jesús
Published: June 2020

Formation of all-carbon-substituted quaternary carbons is a key challenge in organic and medicinal chemistry.
Synthesis of indolizines from pyridinium 1,4-zwitterionic thiolates and α-functionalized bromoalkanes via a stepwise [(5+1)−1] pathway
Authors: Cheng Bin , Zhang Xinping , Li Yuntong , Li Hui , He Yixuan , Li Yun , Wang Taimin , Zhai Hongbin
Published: June 2020

Pyridinium 1,4-zwitterionic thiolates were applied to accessing indolizines via a sequence of annulation, oxidation and ring-contraction/desulfuration.
Transition metal decorated soft nanomaterials through modular self-assembly of an asymmetric hybrid polyoxometalate
Authors: Hampson Elizabeth , Cameron Jamie M. , Watts Julie A. , Newton Graham N.
Published: June 2020

We report the self-assembly of unique, multicomponent Pt2+-decorated micellar nanostructures from an asymmetric hybrid polyoxometalate building block.
Nanoscale nickel–iron nitride-derived efficient electrochemical oxygen evolution catalysts
Authors: Wang Jianmin , Cao Feng , Shen Chen , Li Guoqing , Li Xin , Yang Xi , Li Song , Qin Gaowu
Published: June 2020

Ni3FeN/Ni heterostructures are preparedviachemical etching followed by a nitridation process, and thein situgenerated NiFeOOH/Ni3FeN/Ni exhibits outstanding OER activity.
Probing the non-innocent nature of an amino-functionalised β-diketiminate ligand in silylene/iminosilane systems
Authors: Do Dinh Cao Huan , Vasko Petra , Fuentes M. Ángeles , Hicks Jamie , Aldridge Simon
Published: June 2020

Ring contraction reactions in electron-rich amino-Nacnac silylene complexes are driven by electron releasing and sterically unencumbered silicon-bound substituents.
Triphenylamine/carbazole-modified ruthenium(ii) Schiff base compounds: synthesis, biological activity and organelle targeting
Authors: Chen Shujiao , Liu Xicheng , Huang Jie , Ge Xingxing , Wang Qinghui , Yao Meimei , Shao Yue , Liu Tong , Yuan Xiang-Ai , Tian Laijin , Liu Zhe
Published: June 2020

N-phenylcarbazole/triphenylamine modified Schiff base half-sandwich ruthenium(ii) compounds showed potential anticancer activity against A549 and HeLa cells.
Effect of mitochondrial quality control on the lycopene antagonizing DEHP-induced mitophagy in spermatogenic cells
Authors: Zhao Yi , Li Mu-Zi , Talukder Milton , Luo Yu , Shen Yue , Wang Hao-Ran , Li Jin-Long
Published: June 2020

This study provides new insights and indicates that LYC prevents DEHP-induced mitophagy of spermatogenic cells via the mitochondrial quality regulation, which may be the target molecule for future DEHP toxicity and the LYC effector mechanism.
Metal-enhancement study of dual functional photosensitizers with aggregation-induced emission and singlet oxygen generation
Authors: Tavakkoli Yaraki Mohammad , Hu Fang , Daqiqeh Rezaei Soroosh , Liu Bin , Tan Yen Nee
Published: June 2020

Metal-enhancement study of dual functional AIE-photosensitizers unrevealing the intrinsic correlation between MEF and ME-SOG in the AgNP@AIE-PS nanohybrid system.
Mechanistic insights into surface contribution towards heat transfer in a nanofluid
Authors: Singh Ajit , Lenin Ramanujam , Bari Naimat Kalim , Bakli Chirodeep , Bera Chandan
Published: June 2020

Role of nanoparticle surface in the thermal transport mechanism through nanofluid.
Experimental and computational studies on the formation and biological properties of the simplest polyfluoroalkyl phosphonates
Authors: Zagórski Piotr M. , Tokarz Paulina , Gostyński Bartłomiej , Tokarz Paweł
Published: June 2020

The simplest polyfluoroalkyl phosphonates exhibit high cell-line specific cytotoxicity.
Novel covalent organic nanosheets for the construction of ultrafine and well-dispersed metal nanoparticles
Authors: Lu Feipeng , Li Yaqiong , Shi Qingrong , Zhao Chaofeng , Li Shenghua , Pang Siping
Published: June 2020

CON–DAI–TFP, a pyrazole-functionalized nanosheet structure, demonstrates an efficient strategy for the synthesis of ultrafine, highly dispersed, and high loading U-MNPs, which are urgently needed in industrial and laboratory catalysis.
Picoloyl protecting group in synthesis: focus on a highly chemoselective catalytic removal
Authors: Geringer Scott A. , Mannino Michael P. , Bandara Mithila D. , Demchenko Alexei V.
Published: June 2020

Tested for Glc, GlcN, Gal, Man, NANA and glycans up to tetrasaccharide. Also works for multiple picoloyl groups.
High ionic conductivity of multivalent cation doped Li6PS5Cl solid electrolytes synthesized by mechanical milling
Authors: Hikima Kazuhiro , Huy Phuc Nguyen Huu , Tsukasaki Hirofumi , Mori Shigeo , Muto Hiroyuki , Matsuda Atsunori
Published: June 2020

The performances of next generation all-solid-state batteries might be improved by using multi-valent cation doped Li6PS5Cl solid electrolytes.
First principles study of electronic and nonlinear optical properties of A–D–π–A and D–A–D–π–A configured compounds containing novel quinoline–carbazole derivatives
Authors: Khalid Muhammad , Ali Akbar , Jawaria Rifat , Asghar Muhammad Adnan , Asim Sumreen , Khan Muhammad Usman , Hussain Riaz , Fayyaz ur Rehman Muhammad , Ennis Christopher J. , Akram Muhammad Safwan
Published: June 2020

Materials with nonlinear optical properties have significant applications in nuclear science, biophysics, medicine, chemical dynamics, solid physics & materials science. We show how π bridges, donors & acceptors can be reconfigured to improve optical properties.
Hybrid hollow silica particles: synthesis and comparison of properties with pristine particles
Authors: Sharma Jaswinder , Cullen David A. , Polizos Georgios , Nawaz Kashif , Wang Hsin , Muralidharan Nitin , Smith David Barton
Published: June 2020

Hybrid hollow silica particles, which show different properties compared to their pristine counterparts, have been synthesized.
Effect of iron doped titanium oxide encapsulated in alginate on photocatalytic activity for the removal of dye pollutants
Authors: Chkirida Soulaima , Zari Nadia , Achour Redouane , Qaiss Abou el kacem , Bouhfid Rachid
Published: June 2020

Iron oxide/titania oxide are encapsulated in alginate biopolymer. These bio-nanocomposites are suitable for the photodegradation of dissimilar organic pollutants under UV irradiation as well as visible light.
A titanium dioxide/nitrogen-doped graphene quantum dot nanocomposite to mitigate cytotoxicity: synthesis, characterisation, and cell viability evaluation
Authors: Ramachandran Pravena , Lee Chong Yew , Doong Ruey-An , Oon Chern Ein , Kim Thanh Nguyen Thi , Lee Hooi Ling
Published: June 2020

Cytotoxicity mitigation using titanium dioxide/nitrogen-doped graphene quantum dot nanocomposites.
Investigation of the effect of S/In molar ratio on physical properties of sprayed In2S3 thin films
Authors: Bchiri Y. , Bouguila N. , Kraini M. , Souissi R. , Vázquez-Vázquez C. , López-Quintela M. A. , Alaya S.
Published: June 2020

Indium sulfide (In2S3) thin films have been synthesized on glass substrates using the spray technique (CSP).
Nickel catalyzed intramolecular oxidative coupling: synthesis of 3-aryl benzofurans
Authors: Aggarwal Sakshi , Srinivas Dasari , Sreenivasulu Chinnabattigalla , Satyanarayana Gedu
Published: June 2020

We have developed nickel-catalyzed synthesis of 3-aryl benzofurans from ortho-alkenyl phenols via intramolecular dehydrogenative coupling. O2 gas served as an oxidant and 3-aryl benzofurans were synthesized in good to very good yields.
Purification, characterization, and hypoglycemic properties of eurocristatine from Eurotium cristatum spores in Fuzhuan brick tea
Authors: Liu Gang , Duan Zhiguang , Wang Pan , Fan Daidi , Zhu Chenhui
Published: June 2020

A hypoglycemically active substance was isolated and identified for the first time from the Eurotium cristatum spores in Fuzhuan brick tea.
Amorphous flexible covalent organic networks containing redox-active moieties: a noncrystalline approach to the assembly of functional molecules
Authors: Suzuki Jumpei , Ishizone Akira , Sato Kosuke , Imai Hiroaki , Tseng Yu-Jen , Peng Chi-How , Oaki Yuya
Published: June 2020

Amorphous flexible covalent organic networks containing functional molecules were synthesized by consecutive and multiple reactions at different rates and in multiple directions.
Two-stage athermal solidification of semiflexible polymers and fibers
Authors: Dietz Joseph D. , Hoy Robert S.
Published: June 2020

Many polymers and fibers lie between the flexible limit where “molecules” are random-walk-like and the stiff limit where they are rodlike. We study how these systems' athermal solidification varies throughout the intermediate, semiflexible regime.
Multi valued parity generator based on Sudoku tables: properties and detection probability
Authors: Ghalamdoost Pirbazari Shahab , Souri Alireza , Faghih Mirzaee Reza , Jabbehdari Sam
Published: June 2020

Parity‐check is a simple yet effective error detection method. Several other more sophisticated error detection techniques are founded upon single parity‐check (SPC). Exclusive‐OR (XOR) is known as the parity generator in binary logic. This study suggests some multi‐valued parity generators (MPGs), studies their behaviour, and provides a full discussion about their necessary and optional properties. The concept of Sudoku with some customised rules is used to create MPGs, which are the extended versions of binary parity generator in higher radixes. They are capable of revealing all single‐digit errors. Additionally, they can detect incorrect data delivery with high probability when more than one error occurs (with even higher probability than XOR). The probability of error detection is analytically calculated for the occurrence of two to five errors in different bases. The calculations are then experimentally verified by a formal verification method. The authors’ investigations show that error detection probability increases in higher radixes, and it is independent of dataword size.
Preliminary simulations of flat and parabolic reflectarray antennas to generate a multi‐spot coverage from a geostationary satellite
Authors: Martinez‐de‐Rioja Daniel , Martinez‐de‐Rioja Eduardo , Encinar Jose A. , Rodriguez‐Vaqueiro Yolanda , Pino Antonio
Published: June 2020

This study presents the design process and preliminary results of a 1.8‐m reflectarray antenna able to generate a complete multi‐spot coverage for transmission from a geostationary satellite operating in Ka‐band (18.2–20.2 GHz). The reflectarray is designed using a newly validated method which makes it possible to generate four spaced beams per feed at different frequencies and polarisations. Two different antenna configurations have been evaluated: first, a 1.8‐m flat reflectarray has been designed to produce a total of 108 spot beams in two frequencies and two polarisations using 27 dual‐polarised feeds; then, the design has been extended to consider a 1.8‐m parabolic reflectarray to overcome the limitations related to the phase distributions in large flat reflectarrays. The proposed concept can allow a reduction in the number of antennas and feed chains on board the satellite since only two reflectarray antennas would be needed to produce a four‐colour multi‐spot coverage in Ka‐band, one for transmit and other for receive.
From regression function to diffusion drift estimation in nonparametric setting
Authors: Comte Fabienne
Published: June 2020

We consider a diffusion model dXt = b(Xt)dt + σ(Xt)dWt,X0 = η, under conditions ensuring existence, stationarity and geometrical β-mixing of the process solution. We assume that we observe a sample (XkΔ)0≤k≤n+1. Our aim is to study nonparametric estimators of the drift function b(.), under general conditions. We propose projection estimators based on a least-squares type contrast and, in order to generalize existing results, we want to consider possibly non compactly supported projection bases and possibly non bounded volatility. To that aim, we relate the model with a simpler regression model, then to a more elaborate heteroscedastic model, plus some residual terms. This allows to see the role of heteroscedasticity first and the role of dependency between the variables and to present different probabilistic tools used to face each part of the problem. For each step, we try to see the “price” of each assumption.

This is the developed version of the talk given in August 2018 in Dijon, Journées MAS.
Avaliação do desgaste do polietileno de uma prótese de joelho nacional ultracongruente de base rotatória
Authors: Pécora José Ricardo , Romero Valéria
Published: June 2020

Objetivo Avaliar o desgaste do polietileno de uma prótese de joelho brasileira ultracongruente de base rotatória (Rotaflex, Víncula, Rio Claro, SP, Brasil).

Métodos Utilizou-se o método de ensaio com os parâmetros de carregamento e preparação citados na norma ISO 14243-1:2009, e os métodos de medição citados na norma ISO 14243-2:2009, para a avaliação do comportamento de desgaste de uma prótese nacional com base rotatória. O equipamento utilizado para o teste de desgaste foi o simulador de marcha ISO 14243–1 (EndoLab, Riedering, Alemanha).

Resultados Após 10 milhões de ciclos, a avaliação do desgaste do polietileno mostrou uma aparência regular do desgaste da superfície com taxa média de 2,56 mg por milhão de ciclos.

Conclusão O desgaste do polietileno da prótese avaliada foi mínimo após os ensaios realizados e com os limites de segurança superiores aos preconizados pela engenharia biomecânica.
Spectral measurements of inductively coupled and m = +1, −1 helicon discharge modes of the constructed plasma source
Authors: Khoshhal Mohammadreza , Habibi Morteza , Boswell Rod
Published: June 2020

In the present context, the industrial type of Amirkabir helicon plasma source has been introduced that was designed and constructed at the Helicon Plasma Laboratory of Amirkabir University of Technology with the aim of using it in material processing applications. Helicon plasma in two m = +1 and m = −1 modes of operation was studied, and also its application was compared with the inductively coupled plasma (ICP) mode in this experimental work. This study was performed by employing two techniques including optical emission spectroscopy and imaging using a camera with polarizing filters, in which the images and spectra of ICP and m = +1, −1 helicon plasma modes were recorded under the experimental conditions. The effects of the device operational parameters on the argon plasma emission spectra were investigated in the wavelength range of 350–950 nm. It was observed from the comparison of the plasma spectra that the ionization rate increases significantly for the plasma helicon mode than ICP and also for m = +1 helicon mode of operation than m = −1. In this work, the values of device operational parameters such as the RF power delivered to the half-helix antenna, external magnetic field intensity, and the injected gas flow rate were varied in the range of 400–900 W, 100–300 mT, and 1–10 SCCM in the experiment, respectively. In addition, the optimum values of RF power, magnetic field intensity, and the injected gas flow rate for achieving the maximum ionization rate were, respectively, obtained as 900 W, 300 mT, and 3 SCCM.
Tuning of Schottky barrier height using oxygen-inserted (OI) layers and fluorine implantation
Authors: Zhang Xi , Takeuchi Hideki , Connelly Daniel , Hytha Marek , Mears Robert J. , Rubin Leonard M. , King Liu Tsu-Jae
Published: June 2020

The effects of oxygen-insertion technology and low-energy fluorine (F) implantation on the Schottky barrier height (ΦBp) of a Pt/Ti/p-type Si metal–semiconductor contact are studied via electrical characterizations of Schottky diodes, physical analyses by secondary ion mass spectrometry , and chemical analyses by x-ray photoelectron spectroscopy. It is found that both oxygen-inserted (OI) layers and F can reduce ΦBp due to Ti 2p and Si 2p binding energy shifts before forming gas anneal (FGA) and due to retarded Pt diffusion into Si (facilitating low-ΦBp Pt mono-silicide formation) during FGA. The experimental findings also suggest that OI layers are more effective than F for reducing ΦBp.
Third harmonic working based on the Smith–Purcell radiation in a closed structure
Authors: Wang Bin , Zhang Ping , Li Hailong , Bi Liangjie , Wang Xiaosong , Pan Yilin , Liu Meiqin , Yin Yong , Meng Lin
Published: June 2020

Smith–Purcell radiation is well analyzed in an open structure; however, it is seldom studied in a closed structure. In a high order mode resonant system, the harmonics of the spoof surface plasmon in the subwavelength hole array will be transformed into Smith–Purcell radiation and the radiation energy will be embedded in a high order mode of this resonant system. The spoof surface plasmon and the high order mode have the same field distribution in the beam channel by a special design, and then, the electron beam will interact with them simultaneously. Based on the phenomenon and mechanism, an effective method that works on the higher order harmonic is proposed. It is possible to mitigate the frequency limits as well as the start current limits in vacuum electronic devices, and the mode competition issue is also improved because of the frequency-locked characteristic.
Study of the effect of normal load on friction coefficient and wear properties of CNx thin films
Authors: Kar Satyananda , Sahu Bibhuti Bhusan , Kousaka Hiroyuki , Han Jeon Geon , Hori Masaru
Published: June 2020

The present study reports on the systematic analysis of the friction and the wear behaviors of carbon nitride (CNx) thin films deposited by direct current unbalanced magnetron sputtering. We focus on the normal load dependence on the friction coefficient and wear rate for the sliding friction of the SUJ2 ball with the CNx thin film. The friction coefficient was monitored using a ball-on-disc apparatus with various loads in ambient air. The friction coefficient (μ) increases linearly from ∼0.05 to 0.28 with increasing normal load, while the specific wear rate decreases with an increase in load. The wear rates of the SUJ2 ball ∼1.5 × 10−7 mm3/Nm for μ = 0.05 and ∼5.5 × 10−8 mm3/Nm for μ = 0.28 were observed in the deposited CNx films with the minimum and maximum normal load. The friction and wear mechanisms are discussed in relation to the surface morphology and microstructure of the CNx coatings.
Visible range photoresponse of vertically oriented on-chip MoS2 and WS2 thin films
Authors: Järvinen Topias , Komsa Hannu-Pekka , Kordas Krisztian
Published: June 2020

The excellent electrical properties of transition metal dichalcogenide (TMD) 2D materials promise a competitive alternative to traditional semiconductor materials for applications in optoelectronics, chemical sensing, as well as in energy harvesting and conversion. As the typical synthesis methods of TMDs produce nanoparticles, such as single or multi-layered nanoflakes, subsequent strenuous integration steps are necessary to obtain devices. Direct synthesis of the material on substrates would simplify the process and provide the means for large-scale integration and production of practical devices. In our approach, we synthesize MoS2 and WS2 thin films with a simple sulfurization of the respective metal films deposited by sputtering on Si/SiO2 chips, and study their optoelectrical properties at wavelengths of 661 nm, 552 nm, and 401 nm using pulsed lasers. Both TMD thin films are found to show photoresponsivities of up to ∼5 × 10−6 A W−1 with corresponding quantum efficiencies of ∼10−5, which are unexpectedly moderate, and can be attributed to their columnar microstructure, in which the basal planes of the hexagonal lattices are perpendicular to the substrate, thus, limiting the electron transport in the films parallel to the plane of the substrate.
Gate controllability of HfSiOx/AlGaN/GaN MOS high-electron-mobility transistor
Authors: Ochi Ryota , Maeda Erika , Nabatame Toshihide , Shiozaki Koji , Sato Taketomo , Hashizume Tamotsu
Published: June 2020

Hafnium silicate (HfSiOx) has been applied to AlGaN/GaN high-electron-mobility transistors (HEMTs) as a high κ gate dielectric. The (HfO2)/(SiO2) laminate structure was deposited on the AlGaN surface by a plasma-enhanced atomic layer deposition, followed by a post-deposition annealing at 800 °C. The HfSiOx-gate HEMT showed good transfer characteristics with a high transconductance expected from its κ value and a subthreshold swing of 71 mV/decade. For the metal–oxide-semiconductor (MOS) HEMT diode, we observed excellent capacitance–voltage (C–V) characteristics with negligible frequency dispersion. The detailed C–V analysis showed low state densities on the order of 1011 cm−2 eV−1 at the HfSiOx/AlGaN interface. In addition, excellent operation stability of the MOS HEMT was observed at high temperatures up to 150 °C.
Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted α-particle therapy
Authors: Bicak Mesude , Lückerath Katharina , Kalidindi Teja , Phelps Michael E. , Strand Sven-Erik , Morris Michael J. , Radu Caius G. , Damoiseaux Robert , Peltola Mari T. , Peekhaus Norbert , Ho Austin , Veach Darren , Malmborg Hager Ann-Christin , Larson Steven M. , Lilja Hans , McDevitt Michael R. , Klein Robert J. , Ulmert David
Published: June 2020

Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2;
KLK2
). In multiple rodent models, Actinium-225–labeled hu11B6-IgG
1
([
225
Ac]hu11B6-IgG
1
) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [
225
Ac]hu11B6 treatment. First, we evaluated the possibility of exploiting IgG
3
, the IgG subclass with superior activation of complement and ability to mediate FC-γ-receptor binding, for immunotherapeutically enhanced hK2 targeted α-radioimmunotherapy. Second, we compared the therapeutic efficacy of a single high activity vs. fractionated activity. Finally, we used RNA sequencing to analyze the genomic signatures of prostate cancer that progressed after targeted α-therapy. [
225
Ac]hu11B6-IgG
3
was a functionally enhanced alternative to [
225
Ac]hu11B6-IgG
1
but offered no improvement of therapeutic efficacy. Progression-free survival was slightly increased with a single high activity compared to fractionated activity. Tumor-free animals succumbing after treatment revealed no evidence of treatment-associated toxicity. In addition to up-regulation of canonical aggressive prostate cancer genes, such as
MMP7
,
ETV1
,
NTS
, and
SCHLAP1
, we also noted a significant decrease in both
KLK3
(prostate-specific antigen ) and
FOLH1
(prostate-specific membrane antigen) but not in
AR
and
KLK2
, demonstrating efficacy of sequential [
225
Ac]hu11B6 in a mouse model.
Matter accretion onto Einstein-aether black holes via well-known fluids *
Authors: Shahzad M.Umair , Ali Rafaqat , Jawad Abdul , Rani Shamaila
Published: June 2020

We study matter accretion onto Einstein-aether black holes by adopting the Hamiltonian approach. The general solution of accretion is discussed using the isothermal equation of state. Different types of fluids are considered, including ultra-relativistic, ultra-stiff, sub-relativistic, and radiation fluids, and the accretion process onto Einstein-aether black holes is analyzed. The behavior of the fluid flow and the existence of critical points is investigated for Einstein-aether black holes. We further discuss the general expression and behavior of polytropic fluid onto Einstein-aether black holes. The most important feature of this work is the investigation of the mass accretion rate of the above-mentioned fluids and the comparison of our findings with the Schwarzschild black hole, which generates particular signatures. Moreover, the maximum mass accretion rate occurs near the Killing and universal horizons, and the minimum accretion rate lies between them.
Application of Multinomial Logistic Regression to analyze learning difficulties in statistics courses
Authors: Abdillah A , Sutisna A , Tarjiah I , Fitria D , Widiyarto T
Published: June 2020

Every student basically wants to get the opportunity to achieve satisfactory academic performance. But from daily reality, it seems clear that students have differences in intellectual abilities, physical abilities, family background, habits and learning approaches that are sometimes very striking between a student and other students. The data used in this study consisted of primary data and secondary data. Primary data in the form of a questionnaire for the dependent variable and response variable. While secondary data contains general information on the number of students in the fourth semester of economic education courses obtained from the administration of the faculty of education, Unindra. Data analysis using multinomial logistic regression analysis. Based on the results of this study, independent variables that influence student learning difficulties in Statistics courses include; gender, regional origin, learning motivation, and learning resources. While the variables that did not have a significant effect on learning difficulties include; major at school, monthly tuition allowance, and study patterns. Furthermore, the value of the accuracy of the classification of students produced using multinomial logistic regression analysis of seventy-six point five percent.
Naïve bayes classifier models for cerebral infarction classification
Authors: Fitri SG , Selsi R , Rustam Z , Pandelaki J
Published: June 2020

Cerebral infarction is a condition of tissue damage in the brain caused by inadequate oxygen supply caused by obstruction of the flow of regions to the area (ischemia). Brain ischemia is more common than hemorrhagic, but surgery is most often performed in hemorrhagic strokes. This condition is also called stroke infarction. In stroke infarction does not occur bleeding. Changes in brain blood vessel walls can be primary due to congenital or degenerative abnormalities and secondary processes caused by other processes such as inflammation, arteriosclerosis, hypertension, diabetes mellitus and many other processes, so the cause of stroke is very multifactorial. The final sign of cell damage due to ischemia is marked by the nucleus which becomes picnotic and fragmented. Research shows that stroke infarction can occur at the age of 15-55 years. To diagnose the presence or absence of cerebral infarction in the brain is not enough just to use a CT scan, therefore machine learning will also be used to diagnose the presence or absence of cerebral infarction in the brain. For this reason, the authors propose the Naïve Bayes Classifier method as a classification method that has good accuracy, good precision, good memory, and a good F1-score in calcifying a patient whose brain has cerebral infarction or not. In this proposed method, Naïve Bayes Classifier is a probabilistic machine learning model used to classify. Naïve Bayes Classifier is a simple probability technique based on the Bayes theorem with the assumption of independence among predictors. In simple terms, Naïve Bayes Classifier assumes that the presence of certain features in a class is not related to the presence of other features. This method can achieve an accuracy value of up to 92.43%, so this method can be an efficient classification tool.
A new chaotic map development through the composition of the MS Map and the Dyadic Transformation Map
Authors: Suryadi MT , Satria Yudi , Melvina Venny , Prawadika Luqman N , Sholihat Ita M
Published: June 2020

In this paper, a new chaotic map is proposed, that is obtained from the composition of two chaotic maps, that is, the MS Map and the Dyadic Transformation Map. The composition process starts from the MS Map, followed by the Dyadic Transformation Map. The resulting composition is a new chaotic function. This is shown by the bifurcation diagram analysis result, Lyapunov Exponents, and the NIST randomness test. The bifurcation diagram shows that the best densities occur at λ ∈ (0.3, 5) and r = 3.8. The Lyapunov Exponents has nonnegative values for r ∈ [1, 4]. The NIST randomness test with initial value and parameters x
0 = 0.6, r = 3.8, and λ = 3.5 shows that the new chaotic map passes 14 out of 16 NIST tests.
A game-theoretic model of marketing strategy using consumer segmentation
Authors: Lukitosari V , Simanjuntak T F , Utomo D B
Published: June 2020

Game theory evolves like a biological system with species that evolved under natural selection. Game theory as a means of predicting the distribution of individual behaviour in various fields of business. Companies must learn the best marketing strategies and estimate the steps of their competitors. Marketing strategy analysis is related to decision making when there are two or more parties in a condition of competition or conflict. In this research, determining the marketing strategy is done by paying attention to consumer segmentation. With consumer segmentation generated marketing strategies for certain consumers at a predetermined size. Consumer segmentation is important for producers, among others: the company can manage its products well, know the needs and standards of consumers, and get the optimal marketing strategy.
Goal programming on optimal pairings selection from flight schedule using Bat Algorithm
Authors: Rahmalia D , Chandra N E , Rohmaniah S A , Muzdalifah L , Kurniawati E F
Published: June 2020

Nowadays, the demands of flight service are very high so that flight industry should minimize operational cost such as crew cost. Crew cost depends on pairings from flight schedule. Optimization model of this problem is selecting optimal pairings covering all flight numbers in the goal programming model as multiobjective programming. In this research, goal programming on optimal pairings selection will be applied by heuristic method like Bat Algorithm (BA). BA is optimization method inspired from behavior of bats like they use sonar called echolocation to detect prey, avoid obstacles, and locate their roosting crevices in the dark. BA can be applied on constrained optimization. Simulations are applied by generating the set of pairings and selection using BA. The advantages of BA are there are a local solution around the selected best solution based on pulse rates and loudness. In the optimal pairings selection model, there are three objectives which will be minimized based on order of importance. The simulation results show that Bat Algorithm can be used in goal programming model and it can select optimal pairings in approaching with the number of pairing consisting of two flight numbers is 4 pairings, the number of pairing consisting of three flight numbers is 0 pairing, the number of pairing consisting of four flight numbers is 49 pairings, the number of pairing consisting of five flight numbers is 7 pairings and the number of pairing consisting of six flight numbers is 8 pairings.
Sum Nano-Zagreb Index of Some Graph Operations
Authors: Fansury M C , Rinurwati
Published: June 2020

In this paper, we defined a new invariant graph called Sum Nano-Zagreb index. Sum Nano-Zagreb index is defined by

χ
α

N
Z
(
G
)
=

Σ

u
v
∈

E
G

(

d
2

(
u
)
−

d
2

(
v
)
)

1
/
2

. We determined the Sum Nano-Zagreb index of some graph operations, that is Cartesian, join, corona, edge corona and composition.
Classification and Counting of Moving Vehicle at Night with Similarity of Rear Lamp
Authors: Setiyono B , Susanti R D , Sulistyaningrum DR , Usadha IGN
Published: June 2020

Congestion is caused by a large number of vehicles exceeding road capacity. If we know the amount of the average density of vehicles passing by, it can be a consideration of infrastructure development. Therefore, the authors made a study to classify and calculate vehicles at night using the similarity of vehicles rear lamp. The technique used by authors is to pair each vehicle’s rear lamps that have been detected which have the same characteristics, in this case, We used the similarity of pixels for the pairing process. After that, the pair of rear lamps will be calculated and classified as the type of motorbike or car. This study resulted in a calculation that in Video 1 with not-so-busy traffic conditions able to detect 79 of 88 motorbikes and 32 of 35 cars with accuracy 90,24%. Video 2 with fairly quiet conditions was able to detect 52 of 56 motorcycles and 9 of 11 cars with accuracy 91,04%. Video 3 with crowded traffic conditions can detect 63 of 71 motorcycles and 23 of 29 cars in actual conditions with accuracy 86,00%.
A Mathematical Model for Inventory and Price-Dependent Demand with All-Units Discount
Authors: Limansyah Taufik , Lesmono J. Dharma
Published: June 2020

Inventory becomes one of the factors a company especially a retailer must consider. A good inventory management will guarantee a retailer in running the business. However, inventory management is a difficult task since it is affected by many factors such as the demand fluctuation, deterioration, discount, sales price, uncertain delivery from the supplier and any other factors. Some factors that affect the consumers demand behavior is the quantity of displayed (available) goods and the sales price. When the customers see that there are still a lot of goods available, there is a perception that the goods available is new and fresh, therefore this will induce demand compared to the least available goods on display. On the other aspect, discount offered by the supplier can be exercised to minimize the total inventory cost by ordering more goods. This paper deals with inventory model where demand depends on the inventory level and sales price and also considering all-unit discount from the supplier. From the model, we will find the optimum order quantity and sales price per unit that minimize the total inventory cost.
Economic order quantity model with deterioration factor and all-units discount
Authors: Limansyah Taufik , Lesmono Dharma , Sandy Ign.
Published: June 2020

Inventory related with the illiquid assets for a company and its amount must be carefully calculated. Inventory cost usually consists of purchasing, ordering, holding and shortage cost; however, when there is a possibility that the goods are damage, deteriorated or exceed its expiration date, the so-called deteriorated cost must be considered in the total inventory cost. In this paper we consider an economic order quantity (EOQ) inventory model by considering the possibility of goods to be deteriorated or damage or exceed its expiration date. We also consider an all-units discount scheme offered by the supplier that affect the inventory cost formation in this model. Numerical examples are given to illustrate the model and sensitivity analysis of the shortage cost is also provided. Higher shortage cost will make the total inventory cost higher and the optimal order quantity is obtained by taking the cheapest price the supplier has offered.
Rice disease classification based on leaf image using multilevel Support Vector Machine (SVM)
Authors: Sulistyaningrum Dwi Ratna , Rasyida Alima , Setiyono Budi
Published: June 2020

Plant disease is one of many factors that decrease the quality and quantity value of agriculture, especially rice plants. Automatic technology based on digital image processing is being developed to overcome this problem. Support Vector Machine (SVM) is one of the most used classifications and detection methods. SVM has been developed into multi SVM by combining several binary SVMs to classify more than two classes. In the proposed system, we use one of the multi SVM strategy, namely One Vs. All. The accuracy of classification reaches 86.10% using linear kernel. It has a higher value of accuracy than using polynomial and RBF kernel function. The scenario for the number of the dataset used is 70% for the training set and 30% for the testing set from a whole 240 images.
Application of the stochastic transition matrix as a prediction pattern for the occurrence of disasters in Aceh province in 2017-2021
Authors: Rusdiana Siti , Rusyana Asep , Raja Ahmad Alfaruqi T.
Published: June 2020

Disaster is a series of events that threaten people’s lives. The causes can be from natural factors and human factors that can cause casualties, environmental damage, property losses and psychological impacts. Historically, there have been many disasters in Indonesia, especially in the Aceh province, which has stimulated the government to produce policies of reducing the incidence of disasters, especially disasters caused by human error. The number of floods, fires and landslides occurring annually tends to be similar. Unlike the catastrophic tidal waves, tornadoes, earthquakes, and droughts, such disasters occur randomly and some never occur. Therefore, a method is needed to predict disaster event opportunities, one of which is the Markov chain method. To find out the predicted value of disaster opportunities in the Aceh province for 2017-2021. Based on the results of the study, it is known that the predicted probability of disasters in the province of Aceh in 2017-2021 does not increase and does not decrease in extreme ways from year to year, the accuracy of the predictive value of opportunities for disasters caused by humans (landslides, fires, and floods) in the Province of Aceh in 2017-2021 are classified as reasonable with error value of 26.93%.
A high voltage electrostatic filter for particulate matter PM2.5capture applied in motor vehicle exhaust system
Authors: Wardoyo Arinto Y.P. , Dharmawan Hari A. , Nurhuda M. , Budianto Arif
Published: June 2020

Increasingly strict air pollution regulations along with global warming issue have peeked the interest in cleaner emission emitted by motor vehicle. In line with this, this study was aimed to develop a particulate filtering system based on an electrostatic principle for particulate matter with the diameter less than 2.5 μm, as known as a fine particle, and to test the performance of the filter. The filter consists of aluminum anodes and cathodes as the electrostatic electrodes. These electrodes were placed into the filter frame and installed on a motor vehicle muffler. The test was conducted to estimate the filter performance by measuring particle concentrations before and after using the filters. The filter was tested under four different electrostatic voltages:V1100 Volt,V2200 Volt,V3300 Volt, andV4400 Volt. The results show that the filter can reduce fine particle concentrations with the best efficiency of 50%, 60%, 62%, and 68%, respectively forV1,V2,V3, andV4. Filter performance was directly influenced by the applied voltage and the time of the test.
Beat frequency measurement of the stabilized He-Ne laser 633 nm calibration in SNSU-BSN
Authors: Hapiddin Asep , Yulita Ika P. , Boynawan A.M. , Ratnaningsih  , Agmal Swivano , Novyanto Okasatria
Published: June 2020

In the metrology area, typical stabilized lasers are used as length primary standard. KIM-1, i.e. the iodine stabilized He-Ne laser in National Measurement Standards Laboratory-National Standardization Agency of Indonesia (SNSU-BSN) has been traceable to SI through CCL-K11 inter-laboratory comparison. The result was suitable for KIM-1 to be used as the length primary standard in SNSU-BSN. Beat frequency measurement has been applied in the optical frequency and wavelength calibration system for stabilized He-Ne laser 633 nm using KIM-1 as a reference standard. In the calibration replica, a dual-frequency mode (Agilent 5519B) took a role as DUT laser, which emits a pair of beams with a central wavelength of 632.991 354 nm in the vacuum with frequency difference 3.4 to 4.0 MHz and ±0.02 ppm stability for a typical lifetime. As a measurement result, the beat frequencies of the 1st and 2nd polarized beam of Agilent 5519B against KIM-1 are (121.33±0.06) MHz and (118.59±0.06) MHz.
Dose evaluation of organs at risk during treatment using gamma knife stereotactic radiosurgery (GKSRS): phantom study
Authors: Pontoh P A , Firmansyah O A , Setiadi A R , Tandian D , Pawiro S A
Published: June 2020

Gamma Knife Stereotactic Radiosurgery (GKSRS) treatment requires the high accuracy of delivering single high dose without negative impact on the surrounding tissue. During radiosurgery treatments using GKSRS, the surrounding tissue will receive high scatter radiation because the single dose treatment will employed long irradiation time. Therefore, radiation doses in critical organs of patients during GKSRS treatment is important to be evaluated. In this study, we investigated the radiation dose to the lens, thyroid, breast, uterine fundus, ovaries and testes during treatment using Leksell Gamma Knife Perfexion (LGK; Elekta AB, Stockholm, Sweden). The dose was simulated using the variation of tumour target from 5 to 20 cc. The measurement were performed using variation of collimator size of 4 mm, 8 mm, 16 mm and employed thermoluminescent dosimeters (TLDs) to be placed at the surface of Rando anthropomorphic phantom. TLDs reader Harshaw model 3500 were employed to evaluate the measurement result. The result of this study explains that the dose of organs at risk decrease linearly depend on the distance of the target, target volume and the size of collimator.