bluuebunny/crossref_metadata_2025 huggingface dataset:
Mustard Seed (Brassica nigra) Extract Exhibits Antiproliferative Effect against Human Lung Cancer Cells through Differential Regulation of Apoptosis, Cell Cycle, Migration, and Invasion
Authors: Ahmed Asmaa Gamal , Hussein Usama Khamis , Ahmed Amr E. , Kim Kyoung Min , Mahmoud Hamada M. , Hammouda Ola , Jang Kyu Yun , Bishayee Anupam
Published: April 2020

Lung cancer is the primary cause of cancer-related death worldwide, and development of novel lung cancer preventive and therapeutic agents are urgently needed. Brassica nigra (black mustard) seeds are commonly consumed in several Asian and African countries. Mustard seeds previously exhibited significant anticancer activities against several cancer types. In the present study, we have investigated various cellular and molecular mechanisms of anticancer effects of an ethanolic extract of B. nigra seeds against A549 and H1299 human non-small cell lung cancer cell lines. B. nigra extract showed a substantial growth-inhibitory effect as it reduced the viability and clonogenic survival of A549 and H1299 cells in a concentration-dependent manner. B. nigra extract induced cellular apoptosis in a time- and concentration-dependent fashion as evidenced from increased caspase-3 activity. Furthermore, treatment of both A549 and H1299 cells with B. nigra extract alone or in combination with camptothecin induced DNA double-strand breaks as evidenced by upregulation of γH2A histone family member X, Fanconi anemia group D2 protein, Fanconi anemia group J protein, ataxia-telangiectesia mutated and Rad3-related protein. Based on cell cycle analysis, B. nigra extract significantly arrested A549 and H1299 cells at S and G2/M phases. Additionally, B. nigra extract suppressed the migratory and invasive properties of both cell lines, downregulated the expression of matrix metalloproteinase-2 (MMP2), MMP9, and Snail and upregulated the expression of E-cadherin at mRNA and protein levels. Taken together, these findings indicate that B. nigra seed extract may have an important anticancer potential against human lung cancer which could be mediated through simultaneous and differential regulation of proliferation, apoptosis, DNA damage, cell cycle, migration, and invasion.
Phenolic Compounds of Soybean Seeds from Two European Countries and Their Antioxidant Properties
Authors: Król-Grzymała Angelika , Amarowicz Ryszard
Published: April 2020

There is only a small acreage of planted soybeans in northern Europe, as the global production of this crop is mainly dictated by the warmer temperatures needed for bountiful yields. The defense response of soybean plants to a cold climate entails the secretion of specific compounds which help mitigate oxidative stress, i.e., antioxidants, including phenolic compounds. The objective of this study was to examine differences in the concentrations of phenolic compounds, their antioxidant properties, and the concentration of key isoflavones (namely genistein, daidzein, malonyl daidzein, malonyl genistein, and daidzin) in the seeds of six soybean cultivars from two different regions of Europe, namely Poland and France. The total phenolic contents, isoflavone levels, and in vitro antioxidant capacities of soybean seeds from most of the investigated cultivars of northeast Europe were found to be greater than those from southwest Europe. The phenolic compounds of seed extracts are primarily responsible for the free-radical scavenging of soybeans. Factors regulating the production of phenolic compounds in the seeds have not been thoroughly elucidated. Hence, the results presented in this paper can be useful in the selection of soybean cultivars with higher levels of seed phenolics, because of their beneficial impact on human health and on the soybean’s defense mechanism against plant stresses.
Practical Synthesis of Quinoline-Protected Morpholino Oligomers for Light-Triggered Regulation of Gene Function
Authors: Deodato Davide , Dore Timothy M.
Published: April 2020

Photoactivatable cyclic caged morpholino oligomers (ccMOs) represent a promising tool to selectively regulate gene expression with spatiotemporal control. Nevertheless, some challenges associated with the preparation of these reagents have limited their broader use in biological settings. We describe a novel ccMO design that overcomes many of the challenges and considerably expedites the synthetic preparation. The key factor is the introduction of an ethynyl function on the photocleavable linker to facilitate the use of a Huisgen 1,3-dipolar cycloaddition for the coupling reaction with the oligonucleotide. Compared to previous strategies, this modification reduces the number of synthetic steps and significantly improves the total yield and the stability of the linker. We used the alkynyl-functionalized linker for the preparation of two different ccMOs targeting the mRNA of the glutamic acid decarboxylase genes, gad1 and gad2. HPLC analysis confirms that the caging strategy successfully inhibits the DNA binding ability, and the activity can be restored by brief illumination with 405-nm light. Overall, the straightforward preparation together with the clean and fast photochemistry make these caged antisense reagents excellent tools to modulate gene function in-vivo with spatial and temporal precision.
Leek or Garlic? A Chemical Evaluation of Elephant Garlic Volatiles
Authors: Ascrizzi Roberta , Flamini Guido
Published: April 2020

“Aglione della Valdichiana” is listed among the Traditional Agronomic and Edible Products of Italy, as it is a typical product of the Chiana Valley (Tuscany, Italy). It is also known as “elephant garlic”, due to the dimension of its cloves, and, other than in the Italian Mediterranean area, its presence is also reported in North Africa and Southwest Asia. The current botanical classification identifies it as a leek variety (Allium ampeloprasum L.), although its appearance, except for its larger dimensions, resembles that of garlic. In the present study, the spontaneous volatile emission of whole and cut cloves of “Aglione della Valdichiana” (elephant garlic), garlic, and leek has been profiled by headspace solid phase micro-extraction. The results have been subjected to statistical analyses (analysis of variance, hierarchical cluster, and principal component analysis) to assess whether the chemical profile confirmed the botanical proximity of elephant garlic and leek, rather than garlic. The phytochemical volatiles evaluation indicated a higher proximity of elephant garlic to garlic, rather than leek, at least for the Chiana Valley specimen analyzed in this study.
Development of Chitosan/Mannitol Microparticles as Delivery System for the Oral Administration of a Spirulina Bioactive Peptide Extract
Authors: Aquino Rita P. , Auriemma Giulia , Conte Giulio M. , Esposito Tiziana , Sommella Eduardo , Campiglia Pietro , Sansone Francesca
Published: April 2020

Spirulina platensis contains several compounds showing nutritional and therapeutic benefits. Recently, a series of peptides able to reduce the blood pressure level and to enhance the endothelial vasorelaxation was isolated from the hydrolyzed highly water-soluble Spirulina extract (HSE). However, HSE shows critical organoleptic characteristics also having poor intestinal permeability, limiting absorption when orally delivered. This research aims to overcome the critical issues through the encapsulation of HSE in Chitosan/Mannitol—(CM)-based microparticles by spray drying. The produced powders (CM-HSE) showed good process yield (≈70%) and encapsulation efficiency (≈100%) also having good derived flow properties as well as stability up to six months storage. The microparticles constituting the spray-dried powder resulted in an amorphous micrometric state (d50 ≈ 14 µm) able to retain dark colour and unpleasant smell of raw HSE. Moreover, the in vitro permeation study by Franz cell indicated that the engineered microparticles are able to enhance the permeation of HSE through an intestinal biomimetic barrier (551.13 μg/cm2 CM-HSE vs. 315.46 μg/cm2 HSE at 270 min).
Lactobacillus-Derived Bioactive Metabolites for the Regulation of Periodontal Health: Evidences to Clinical Setting
Authors: Sulijaya Benso , Takahashi Naoki , Yamazaki Kazuhisa
Published: April 2020

Background: Gut microbiota plays a pivotal role in regulating host metabolism that affects the systemic health. To date, several studies have confirmed the fact that microbiota interacts with host, modulating immunity, controlling the homeostasis environment, and maintaining systemic condition. Recent studies have focused on the protective function of poly unsaturated fatty acids, 10-oxo-trans-11-oxadecenoic acid (KetoC) and 10-hydroxy-cis-12-octadecenoic acid (HYA), generated by gut microbiota on periodontal disease. Nevertheless, the mechanism remains unclear as investigations are limited to in vivo and in vitro studies. In this present review, we found that the administration of metabolites, KetoC and HYA, by a probiotic gut microbiota Lactobacillus plantarum from linoleic acid is found to inhibit the oxidation process, possess an antimicrobial function, and prevent the inflammation. These findings suggest the promising use of functional lipids for human health. Conclusion: Protective modalities of bioactive metabolites may support periodontal therapy by suppressing bacterial dysbiosis and regulating periodontal homeostasis in the clinical setting.
Molecular Properties and New Potentials of Plant Nepenthesins
Authors: Bekalu Zelalem Eshetu , Dionisio Giuseppe , Brinch-Pedersen Henrik
Published: April 2020

Nepenthesins are aspartic proteases (APs) categorized under the A1B subfamily. Due to nepenthesin-specific sequence features, the A1B subfamily is also named nepenthesin-type aspartic proteases (NEPs). Nepenthesins are mostly known from the pitcher fluid of the carnivorous plant Nepenthes, where they are availed for the hydrolyzation of insect protein required for the assimilation of insect nitrogen resources. However, nepenthesins are widely distributed within the plant kingdom and play significant roles in plant species other than Nepenthes. Although they have received limited attention when compared to other members of the subfamily, current data indicates that they have exceptional molecular and biochemical properties and new potentials as fungal-resistance genes. In the current review, we provide insights into the current knowledge on the molecular and biochemical properties of plant nepenthesins and highlights that future focus on them may have strong potentials for industrial applications and crop trait improvement.
Macrophage Cell-Cell Interactions Promoting HIV-1 Infection
Authors: Dupont Maeva , Sattentau Quentin James
Published: April 2020

Many pathogens infect macrophages as part of their intracellular life cycle. This is particularly true for viruses, of which HIV-1 is one of the best studied. HIV-1 infection of macrophages has important consequences for viral persistence and pathogenesis, but the mechanisms of macrophage infection remain to be fully elucidated. Despite expressing viral entry receptors, macrophages are inefficiently infected by cell-free HIV-1 virions, whereas direct cell-cell spread is more efficient. Different modes of cell-cell spread have been described, including the uptake by macrophages of infected T cells and the fusion of infected T cells with macrophages, both leading to macrophage infection. Cell-cell spread can also transmit HIV-1 between macrophages and from macrophages to T cells. Here, we describe the current state of the field concerning the cell-cell spread of HIV-1 to and from macrophages, discuss mechanisms, and highlight potential in vivo relevance.
The Financial Statement Analysis of Commercial Banks in Bahrain: A case study of Ahli United Bank
Authors: Qadri Faran Ahmad
Published: April 2020

Financial sector of kingdom of Bahrain intensely supports the growth of the economy. It contributed 27% of Bahrain GDP in 2018.The wellbeing of an economy can be examined by financial performance of the bank. Financial performance is the result of its policies and operations in monetary terms. The aim of the study is to examine the financial performance of the banks in Kingdom of Bahrain- A Case study approach. For the evaluation of the performance of bank, secondary data was collected from the annual audited report of the bank for the period of 2011 to 2017. It focuses on two important indicators the profitability and liquidity. As the shareholders are in need to maximize their return on investment and the depositors need to get back their savings according to their needs focuses on liquidity. To measure the profitability, return on asset and return on equity is the variable and loan to deposit and loan to asset to evaluate the liquidity. For this ratio analysis is being used to measure as it is evident from the previous studies. The study used percentage analysis, descriptive statistics and correlation the result of the analysis portrayed that return on asset and return on equity are positively correlated and negatively correlated with loan to asset.
ANALISIS FAKTOR PREDISPOSISI DENGAN KEJADIAN PERILAKU KEKERASAN PADA PASIEN GANGGUAN JIWA DI RSUD 45 KABUPATEN KUNINGAN TAHUN 2019
Authors: Novalia Vica , Heriana Cecep , Nugraha Moch Didik
Published: April 2020

Gangguan jiwa menjadi masalah serius baik secara global maupun nasional,  regional bahkan pada tingkat lokal. Gangguan jiwa di Kabupaten Kuningan terus meningkat setiap tahunnya, termasuk yang melakukan perawatan di Rumah Sakit, 40% diantaranya pasien dengan perilaku kekerasan. Pasien yang dirawat dirumah sakit dengan diagnosa yang sama mempunyai faktor predisposisi yang berbeda beda, faktor predisposisi yang berbeda ini merupakan informasi yang penting untuk dijadikan dasar pedoman asuhan keperawatan pada pasien dengan gangguan jiwa. Penelitian ini bertujuan untuk Menganalisis Faktor Predisposisi dengan Kejadian Perilaku Kekerasan pada Pasien Gangguan Jiwa di RSUD 45 Kabupaten Kuningan  Tahun 2019.

Jenis Penelitian analitik observasional dengan pendekatan cross sectional. Populasi penelitian seluruh pasien jiwa dari bulan januari - maret sebanyak 68 orang. Sampel penelitian ini adalah seluruh Pasien jiwa di RSUD 45 Kabupaten Kuningan yaitu sebanyak 68 responden dan diambil dengan Teknik total sampling Data dari pasien dan di konfirmasi ke keluarganya diperoleh melalui kuesioner, data penelitian dianalisis dengan menggunakan uji chi square.

Analisis Bivariat faktor biologis ρ value = 0,002, faktor psikologis ρ value = 0,004, faktor sosial budaya ρ value = 0,003. Kesimpulan : terdapat  hubungan faktor biologis, faktor psikologis dan faktor sosial budaya terhadap perilaku kekerasan pasien gangguan jiwa di RSUD 45  Kabupaten Kuningan tahun 2019. Saran Bagi pasien serta keluarga diharapkan menjalankan setiap instruksi yang diberikan oleh perawat atau tim medis selama menjalani perawatan. Keluarga sebaiknya memberikan dukungan secara tepat selama perawatan di rumah sehingga mengurangi adanya kekambuhan pada waktu yang akan datang
HUBUNGAN TINGKAT STRES DENGAN SIKLUS MENSTRUASI PADA MAHASISWA KEBIDANAN TINGKAT I DI STIKES KUNINGAN TAHUN 2019
Authors: Herwandar Fera Riswidautami , Russiska Russiska , Fakhrudin Intan Maharani
Published: April 2020

Permasalahan kesehatan pada remaja yang menduduki persentasi terbesar dibanding yang lainnya adalah gangguan menstruasi. Gangguan pada siklus menstruasi (durasi perdarahan yang lebih lama dan ketidakteraturan siklus) disebabkan oleh beberapa faktor, salah satunya ialah stres. Stres diketahui sebagai faktor-faktor penyebab (etiologi) terjadinya gangguan siklus menstruasi. Stres akan memicu pelepasan hormon kortisol dimana hormon kortisol ini dijadikan tolak ukur untuk melihat derajat stres seseorang. Hormon kortisol diatur oleh hipotalamus otak dan kelenjar pituitari, dengan dimulainya aktivitas hipotalamus, hipofisis mengeluarkan FSH dan proses stimulus ovarium akan menghasilkan estrogen. Penelitian yang dilakukan oleh Pelayanan Kesehatan Peduli Remaja (PKPR) dibawah naungan World Health Organization (WHO) menyebutkan bahwa permasalahan remaja di Indonesia adalah seputar permasalahan yang mengenai gangguan menstruasi. Tujuan penelitian ini adalah untuk mengetahui hubungan tingkat stres dengan siklus menstruasi pada mahasiswa kebidanan tingkat I di STIKES Kuningan tahun 2019. Penelitian ini menggunakan desain penelitian kuantitatif dengan pendekatan Cross Sectional. Populasi dalam penelitian ini adalah mahasiswa kebidanan tingkat I di STIKES Kuningan tahun 2019 sebanyak 41 responden. Analisis yang digunakan analisis univariat dan bivariat dengan menggunakan uji Rank Spearman. Hasil penelitian menunjukkan adanya hubungan tingkat stres dengan siklus menstruasi pada mahasiswa kebidanan tingkat I di STIKES Kuningan, dari 41 responden terdapat 18 (44%) responden yang mengalami stres sedang, pada siklus menstruasi yang tidak teratur terdapat 25 (61%) responden. Hasil uji rank spearman,  yakni p value = 0,01 (<0,05) yang ada hubungan antara tingkat stres dengan siklus menstruasi. Berdasarkan hasil penelitian penulis dapat menyimpulkan bahwa terdapat hubungan yang signifikan antara tingkat stres dengan siklus menstruasi pada mahasiswa kebidanan tingkat I di STIKES Kuningan tahun 2019. Bagi institusi Pendidikan khususnya Program Studi Diploma III Kebidanan diharapkan dapat membuat sebuah program edukasi mengenai manajemen stres pada remaja yang bisa dilakukan secara rutin di luar jadwal perkuliahan.
HUBUNGAN INTERNET ADDICTION DENGAN INTERAKSI SOSIAL PADA REMAJA DI SMA NEGERI 8 BANDUNG
Authors: Nurlianawati Lia , Kuspianitah Diyawati , Dirgahayu Inggrid
Published: April 2020

Remaja dengan segala karakteristik dan tugas perkembangannya tidak lepas dari perkembangan teknologi yang semakin canggih,  remaja memanfaatkan fasilitas internet dengan berbagai macam kebutuhan termasuk kebutuhan bersosialisasi. Kebiasaan yang sering menghabiskan banyak waktu dengan berkomunikasi melalui media, sehingga waktu yang mereka gunakan untuk berkomunikasi secara langsung akan berkurang, selain itu juga dapat mengakibatkan kecanduan terhadap internet. Jumlah pengguna internet tahun 2017 telah mencapai 143,26 juta jiwa (54,68%) dari total jumlah penduduk di Indonesia, pulau jawa mendominasi (58,08%), dan kebanyakan pengguna internet adalah remaja usia 13-18 tahun (75.50%). Penelitian ini bertujuan untuk mengetahui bagaimana hubungan antara internet addiction dengan interaksi sosial pada remaja di SMA Negeri 8 Bandung. Jenis penelitian ini adalah deskriptif korelatif dengan pendekatan cross sectional. Populasi sebanyak 873 siswa dengan sampel dalam penelitian ini yaitu 90 siswa SMA Negeri 8 Bandung, Hasil Analisa univariat menunjukan hampir seluruh dari siswa (86.7%) mengalami internet addiction dan sebagian besar siswa memiliki interaksi sosial yang kurang baik (62.2%). Hasil penelitian didapatkan nilai p-value = 0.000 sehingga disimpulkan terdapat hubungan antara internet addiction dengan interaksi sosial pada remaja di SMA Negeri 8 Bandung. Berdasarkan hasil penelitian disarankan pihak sekolah mengadakan kebijakan mengenai pembatasan penggunaan internet hanya untuk kegiatan pembelajaran ketika berada di lingkungan sekolah.
HUBUNGAN ANTARA GAYA KEPEMIMPINAN KEPALA PUSKESMAS DENGAN KINERJA PUSKESMAS RAWAT INAP DI KABUPATEN KUNINGAN TAHUN 2018
Authors: Gunawan Raynal Aldy , Pranatha Aria , Ramadhy Asep Supyan
Published: April 2020

Kepemimpinan merupakan cara seorang pemimpin dalam mempengaruhi perilaku bawahannya agar mau bekerjasama dan bekerja secara produktif demi tercapainya tujuan dari organisasi. Ketersediaan sumber daya manusia menjadi permasalahan terhadap kinerja Puskesmas rawat inap yang ada di Kabupaten Kuningan. Tujuan penelitian ini mengetahui hubungan antara gaya kepemimpinan kepala Puskesmas dengan kinerja Puskesmas rawat inap di Kabupaten Kuningan.

Rancangan penelitian ini adalah Cross Sectional. Sampel dalam penelitian ini adalah sebanyak 130 orang dengan teknik pengambilan sampel secara Proportionate Stratified Random Sampling. Pengambilan data dilakukan dengan menggunakan kuesioner dan lembar observasi kemudian dianalisis secara univariat dengan menggunakan distribusi frekuensi dan bivariat dengan menggunakan chi square dengan standar signifikan (0,05).

Hasil analisis univariat menunjukan bahwa gambaran gaya kepemimpinan Kepala Puskesmas rawat inap yaitu gaya kepemimpinan demokratis sebanyak 105 responden (80,8%), kemudian kinerja Puskesmas yaitu kategori sedang sebanyak 66 responden (50,8%), sedangkan cakupan pelayanan yaitu kategori kurang sebanyak 80 responden (61,5%), dan manajemen pelayanan yaitu kategori baik sebanyak 117 responden (90,0%) serta mutu pelayanan yaitu kategori baik sebanyak 60 responden (46,2%). Hasil analisis  Chi Square menunjukkan terdapat Hubungan antara gaya kepemimpinan kepala Puskesmas dengan Kinerja Puskesmas dengan (p value = 0,000), kemudian cakupan pelayanan dengan (p value = 0,000), sedangkan mutu pelayanan dengan (p value = 0,000) dan tidak terdapat hubungan antara gaya kepemimpinan Kepala Puskesmas dengan manajemen  pelayanan Puskesmas dengan (p value = 0,179).

Hasil penelitian disimpulkan bahwa gaya kepemimpinan kepala puskesmas rawat inap di kabupaten Kuningan adalah gaya kepemimpinan demokratis. Sedangkan untuk kinerja Puskesmas kategori sedang, kemudian cakupan pelayanan kategori kurang, serta manajemen pelayanan dan mutu pelayanan Puskesmas dalam kategori baik. Dengan hasil penelitian ini disarankan untuk kepala Puskesmas menerapkan gaya kepemimpinan yang otoriter, karena dalam melakukan pelayanan kesehatan pegawai/karyawan dituntut untuk lebih optimal dalam memberikan pelayanan. Karena sangatlah berpengaruh terhadap kepuasan masyarakat terhadap pelayanan yang diberikan. Sehingga para pemimpin mendesak para bawahannya agar lebih meningkatkan mutu pelayanan kepada masyarakat.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PERILAKU HIDUP BERSIH DAN SEHAT (PHBS) PADA SISWA/I DI MADRASAH IBTIDAIYAH NEGERI 12 CIAMIS, TAHUN 2019
Authors: Jaksa Suherman , Ismaniar Indah Nur
Published: April 2020

Data Dinas Kesehatan Kabupaten Ciamis Tahun 2017 mengenai penyakit yang disebabkan rendahnya PHBS menunjukkan bahwa sebanyak 30.501 kasus diare, 47 kasus DBD dan 6.598 kasus pneumonia terjadi dalam satu tahun tersebut. Hasil survei pendahuluan, pelaksanaan PHBS oleh siswa/i di Madrasah Ibtidaiyah Negeri 12 Ciamis belum optimal dikarenakan masih terdapat indikator PHBS yang belum dilaksanakan, kemudian tidak berjalannya kegiatan UKS dan tidak tersedia dengan lengkap sarana prasarana seperti sabun cuci tangan. Tujuan penelitian ini untuk mengetahui faktor-faktor yang berhubungan dengan perilaku hidup bersih dan sehat pada siswa/i di Madrasah Ibtidaiyah Negeri 12 Ciamis, Jawa Barat Tahun 2019. Desain penelitian adalah cross sectional dan sampel sebanyak 66 siswa/i kelas IV, V, dan VI. Pengambilan data dengan wawancara menggunakan kuesioner, analisis data univariat dan bivariat menggunakan uji chi-square dengan α = 0,05. Hasil penelitian menunjukkan bahwa peran guru dengan nilai OR 6,89 (p-value = 0,001), pengaruh teman sebaya dengan nilai OR 4,12 (p-value = 0,009), umur  dengan OR 1,12 (p-value = 1,000), jenis kelamin nilai OR 2,16 (p-value = 0,110), pengetahuan 1,93 (p-value = 0,234), sikap OR 1,99 (p-value = 0,212), dan sarana prasarana OR 1,11 (p-value = 0,245). Ada hubungan antara peran guru dan pengaruh teman sebaya dengan perilaku hidup bersih dan sehat, sedangkan tidak ada hubungan antara umur, jenis kelamin, pengetahuan, sikap, dan sarana prasarana dengan perilaku hidup bersih dan sehat. Pihak sekolah perlu menyediakan sabun cuci tangan, larangan merokok, kantin sehat, dan poster kesehatan untuk penerapan perilaku hidup bersih dan sehat.
OPTIMASI WAKTU HIJAU PERSIMPANGAN BERSINYAL DI WILAYAH PERKOTAAN
Authors: Andrean Maulana  , Aldriansyah Ki Agus
Published: April 2020

Bandung merupakan kota metropolitan terbesar di Provinsi Jawa Barat yang kepadatan penduduknya terus meningkat setiap tahun. Kondisi ini berakibat terhadap peningkatan pergerakan masyarakat dan kemacetan lalu lintas pada jaringan jalan.  Salah satu persimpangan jalan di kota Bandung yang sering mengalami kemacetan adalah pesimpangan jalan Ir. H. Juanda – Siliwangi. Permasalahan yang terjadi yaitu besarnya volume lalu lintas  sehingga menyebabkan panjang antrian dan tundaaan yang besar. Usaha untuk menurunkan panjang antrian dan tundaan salah satunya dengan optimasi waktu hijau persimpangan bersinyal. Penilaian kinerja simpang dilakukan dengan alat bantu model mikrosimulasi. Hasil penelitian ini adalah terdapat perubahan panjang antian dan tundaan setelah dilakukan optimasi waktu hijau yaitu terdapat penurunan panjang antrian dan tundaan pada jalan Ir. H. Juanda (utara) dan peningkatan panjang antrian dan tundaan pada jalan Ir. H. Juanda (selatan).
FAKTOR PENYEBAB PEMBENGKAKAN BIAYA YANG BERPENGARUH TERHADAP BIAYA AKHIR PADA PROYEK KONSTRUKSI GEDUNG
Authors: Sari Meassa Monikha , Hadi Tb. Sofwan , Aldiansyah
Published: April 2020

Pada tahapan pelaksanaan pembangunan proyek konstruksi sering muncul masalah dan kendala yang berasal dari berbagai faktor sehingga tidak jarang pelaksanaan proyek konstruksi tidak hanya terlambat penyelesaiannya tetapi juga mengalami kerugian yang amat besar atau mengalami pembengkakan biaya. Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor apa saja yang menjadi penyebab pembengkakan yang berpengaruh pada biaya akhir proyek konstruksi gedung, serta untuk mengetahui bagaimana hubungan dan besar pengaruh faktor tersebut terhadap biaya akhir. Pengambilan data pada penelitian ini adalah dengan cara melakukan penyebaran kuesioner kepada para tenaga kerja di 4 proyek konstruksi gedung di Tangerang, Banten. Pengolahan data dilakukan dengan menggunakan program SPSS 23. Berdasarkan hasil pengolahan data didapat urutan faktor-faktor yang menjadi penyebab pembengkakan di antaranya: a. Cuaca buruk yang mempengaruhi turunnya produktivitas pekerja; b. Informasi gambar proyek yang tersedia tidak lengkap/kurang dan Banyak hasil pekerjaan yang harus diulang karena cacat/salah (mutu jelek); c. Sering terjadi penundaan pekerjaan dan Terjadi gempa bumi, longsor dan kebakaran hutan sehingga proyek terhenti sementara; d. Informasi lingkup pekerjaan tidak lengkap; e. ketidaktepatan estimasi dan Sering terjadi perubahan lingkup pekerjaan/pelaksanaan. Terdapat hubungan yang sangat kuat antara faktor-faktor penyebab pembengkakan biaya terhadap biaya akhir dengan nilai korelasi pearson 0,813 serta didapat besar pengaruh sebesar 65,3% dari faktor penyebab pembengkakan terhadap biaya akhir proyek.
MAKNA MUSLIM DAN KAFIR PERSPEKTIF FARID ESACK SERTA IMPLIKASINYA TERHADAP KERUKUNAN UMAT BERAGAMA DI INDONESIA
Authors: Robiah Dewi
Published: April 2020

The encounter matter of islam and another religion often occur the conflict and its cause of the narrow perspective of one side or with his own truth and blame each other so it lapsed in “Disbelief”. This assumption can lead to the understanding of extremism. That worldview and narrow perspective can threaten the harmony of the people and inter-religious harmony. This research uses library research method, in which the data used are library data which is related to Farid Esack's thoughts and figures' thoughts related to the meaning of Muslim pronunciation and infidels in the al-Qur’an, with the use of the text approach method, Critical Discourse Analysis Norman Fairclough. Pursuant to Esack, Islam is the total surrender of humanity to God, bearing all the consequences of that faith. Esack gives a broader definition of pagan, that pagan doctrinally means different beliefs; there are infidels socio-political; infidel in the sense of fighting justice. According to Esack, the initial idea of ​​disbelief seemed to be mixed with divinity. According to Esack, the initial idea of ​​disbelief seemed to be mixed with divinity. Even though the infidels also recognize the existence of God. So actually infidels are oppression as opponents or contradictions of faith embodied in compassion, peace, togetherness, and prosperity. Re-understanding of the meaning of Muslims and infidels by Esack, contributing to the struggle that is praxis, leaving behind the rigidity of understanding, exclusivity, religious exclusion and reluctance to fight together.
Seismic Study of Multistorey Building using Floating Column
Authors:   Civil Engineering Department , Amal Jyothi College Of Engineering & Technology, Kanjirapally, India., R Sreadha A , Pany Dr. C. ,   Engineer, VSSC, Trivandrum, Kerala, India.
Published: April 2020

Columns rest on the beam without foundation are called floating column.They are used commonly in multi-storey buildings which are purposed to hold parking at ground floor or open halls at higher floors. Discontinuation within the load transfer path is seen in this column. Thus theyare designed for gravity loads. But these structures aren’t designed for earthquake loads.In present scenario structures withfloating column may be a commoncharacteristic in urban India.However in tectonic areas, this type of structure is not preferred due to discontinuity of load transfer path i.e. whole earthquake load on the structure is shared by the shear walls without any loads on the floating columns.This paper review the nature of a multi-storey building under quake forces with and without of floating columns.This analysis focus the importance of specially identifying the presence of the floating column within the study of the struture, establish its correlation with the building without a floating column using designing software Extended three dimensional analysis of building systems (ETABS). This paper also discusses the performance of structure having floating column in seismically active areas. Besides these various parameter such as maximum displacement, effect on number of storey on drift, base shear are also studied.
IoT based Speed Monitoring System based on Location of the Vehicle
Authors:   Department of Computer Science and Engineering, Kattankulathur Campus, SRM Institute of Science and Technology, Chennai, India, Unadket* Ashish , Yadav Vikas ,   Department of Computer Science and Engineering, Kattankulathur Campus, SRM Institute of Science and Technology, Chennai, India., Sivakumar Dr. B. ,   Department of Computer Science and Engineering, Kattankulathur Campus, SRM Institute of Science and Technology, Chennai, India.
Published: April 2020

Nowadays there is an increasing amount of road accidents happening around the world. The amount of road accidents is especially high in metropolitan cities. The main reason for road accidents is almost always due to the negligence on part of the driver. Maximum number of Road Accidents occur due to over-speeding and drunk driving. This system helps detect over-speeding vehicles by directly implementing the particular hardware inside the vehicle itself and depending on the GPS position of the car and regional speed limits alert the authorities based on the violation. This technique helps us to reduce costs which need to be incurred to install speed cameras at roads at regular intervals. The system will detect the speed of the car, and in case of a violation the license plate number along with the registration details and the photo of the driver will be directly sent to the concerned authorities. This system aims to decrease the amount of accidents that happen across the globe and help conserve human lives. Road accident still remain one of the highest contributors to the loss of human life. For experimental results, we used raspberry pi and the GPS antenna for detection of over speed and alert the authorities on violation.
Behaviour of Autoclaved Aerated Concrete Blocks using Alkali-Resistant Glass Fibre as Additive.
Authors:   M. Tech student, Department of Civil Engineering, Integral University, Lucknow, India., Bhat* Anayatullah , Khan Zishan Raza ,   Associate Professor, Department of Civil Engineering, Integral University, Lucknow, India.
Published: April 2020

Autoclaved aerated concrete (AAC) blocks are the lightweight and green concrete blocks that are composed of cement, fly ash, lime, gypsum and aluminium powder. Depending on its density AAC consists of up to 80% of air by volume. Due to their low density and lightweight Autoclaved aerated concrete blocks exhibit so many favourable physical properties that these have got attention from all around the globe. Due to these enhanced properties Autoclaved aerated concrete blocks are extensively used as masonry units in all types of construction. On one hand AAC blocks have no comparison with other types of masonry units in terms of physical properties but on other hand AAC blocks are found to have low compressive strength relatively. In this study an attempt has been made to study the influence of Alkali-Resistant Glass Fibre additive on the physical and mechanical properties of Autoclaved aerated concrete blocks. Four sets of samples were cast and named as A, B, C and D with the fibre additive contents as 0%, 0.1%, 0.2% and 0.3% respectively (by dry weight of all the ingredients).Each sample set consisted of three specimens and the average value of the three samples were taken. For example, the average value of the three specimens- A1, A2, and A3 was taken as A and so on. Fibre additive influenced the aeration process of Autoclaved aerated concrete by increasing the rising/aeration time by 8%. The investigated fibre additive increases the compressive strength by 0%, 10%, 24% and 13.8% respectively to the added fibre contents of 0%, 0.1%, 0.2%, and 0.3% respectively. The optimal content of Alkali-Resistant Glass Fibre additive to be added for obtaining the highest compressive strength is 0.2%. Further investigations have shown a slight variation in density (about 0.2%) between the normal and modified Autoclaved aerated concrete blocks.
Experimental Examination of Weld Hardness Profile with Various Tool Pin Probes using Friction Stir Welding of AA 6082-T6 Aluminium Alloy
Authors:   Department of Mechanical Engineer, Gitam University, Hyderabad, India., Varma* Mr. Kalidindi Vijaya Krishna , Sneha Ms. P. ,   Department of Mechanical Engineer, CMRCET, Hyderabad, India., Kumar Dr. B.V.R Ravi ,   Professor, Department of Mechanical Engineering, VNR Vignana Jyothi Institute of Engineering and Technology, Hyderabad, India., Ramana Dr. M. Venkata ,   Professor, Department of Automobile Engineering, VNR Vignana Jyothi Institute of Engineering and Technology, Hyderabad, India.
Published: April 2020

In the present research work, an attempt was made to evaluate the weld hardness profile on the weldments along the weld traverse direction fabricated using various tool pin probes (Concave triangular threaded probe, Inner rake angle probe, Flats on edges of probe and Scroll threaded flute probe) at three different rotational speeds 1000 rpm, 1200 rpm, 1400 rpm at single weld traverse speed 25 mm/min. Hardness profiles are useful for establishing interpretation on microstructure and weld mechanical properties, micro hardness was performed in order to outline the weld hardness profile in the vicinity of weld affected areas like Nugget zone, Thermo-mechanically affected zone, Heat affected zone and Boundary zone in the weldments. From the hardness profiles it was found that higher hardness value of 106 VHN1kg (Vicker’s Hardness Number at 1kg load) was obtained with the weldment fabricated using Scroll threaded flute probe at 1400 rpm and 25 mm/min i.e 15 mm distance away from the weld centreline on the advancing side of the weldment , besides lower hardness value of 49.8VHN1kg was obtained with weldment fabricated using concave triangular threaded probe at 1200 rpm and 25 mm/min at nugget zone i.e at the centerline of the weldment.
Design and Fabrication of Gloves for Cold Temperature Field Work
Authors:   SBAS, Galgotia university, greater Noida, U. P., India,, Anupama*  , Kumar Chandan ,   Department of Mechanical Engg., Noida Institute of Engineering and Technology, Gr. Noida, UP, India, kumar* Jitendra ,   Department of Mechanical Engg., Noida Institute of Engineering and Technology, Gr. Noida, U.P., India., ranjan R. K. ,   Mech. Engg, Govt. polytechnic, Lahisarai, Bihar, India
Published: April 2020

Conducting field work in cold temperature was a difficult task. The most important safety consideration for field work was to maintain normal body temperature and the proper flexibility of the hand. Heat production and insulation was done through multiple thin layers needed for different temperature and activity level. This work had been focused on the design and fabrication of gloves with minimum thickness and minimum heat loss. The multilayered construction is 44% thinner and 17.5% lighter than the existing materials.
Vibration Signature Analysis using Rough Sets and Analogy-Based Reasoning Classification
Authors:   Department of Electronics Engineering, J.C. Bose University of Science and Technology, YMCA, Faridabad, India., Grover* Chhaya , Turk Dr. Neelam ,   J.C. Bose University of Science and Technology, YMCA, Faridabad, India.
Published: April 2020

Various machine learning techniques along with vibration signal processing techniques are being explored for effective and accurate fault diagnosis of bearing faults. This work studies and evaluates the application of rough set based algorithms - RoughSet Classifier, LocalKnn Classifier and RseslibKnn Classifier and their combinations with 4 kinds of distance metrics - City block and Hamming (CBD and HD), City block and simple value difference (CB and VDM), Density based value difference (DBVDM), Interpolated value difference(IVDM) for bearing vibration signature analysis. The input vector fed to the classifier models is composed of statistical features extracted from pre-processed vibration signals. The different metrics used to compare the performance of the classifiers show that RseslibKnn classifier with City block and simple value difference distance metric takes considerably less time for training (9.09 sec) and classification (0.86 sec) while giving testing accuracy of 84.1442 %, thereby confirming its usefulness for real time application on large bearing fault datasets. The results obtained in this paper show the effectiveness of rough sets based algorithms, particularly KNN based classifiers, in bearing fault diagnosis.
Supply Chain with Blockchain Technology-Based at Automotive Industry
Authors:   Department of Information Systems, School of Information Systems, BINUS Graduate Program-Doctor of Computer Science, Bina Nusantara University, Jakarta, Indonesia., Surjandy*  , Meyliana*  ,   Department of Information Systems, School of Information Systems, Bina Nusantara University, Jakarta, Indonesia., Warnars Harco Leslie Hendric Spits ,   Department of Computer Science, BINUS Graduate Program – Doctor of Computer Science, Bina Nusantara University, Jakarta, Indonesia., Abdurachman Edi ,   Department of Computer Science, BINUS Graduate Program – Doctor of Computer Science, Bina Nusantara University, Jakarta, Indonesia.
Published: April 2020

The research of adoption Supply Chain Management System (SCMS) Blockchain Technology-based in automotive industry still infancy. Based on several research reports recently, the significant development of automotive market causes several issues in SCMS automotive components industry such as fake component. However, fake component might possible to create problems from financial implication until loss of life. This research tries to elaborate Blockchain Technology (BT). Blockchain Technology as identified might be possible as a way out for development of SCMS automotive components. There are several research questions in this research such as how BT can facilitate the SCMS issues? What is the BT adoption success factor for implementation of BT in SCMS? Therefore, this study is essential for industry to develop SCMS by adopting Blockchain technology. The study method used systematic literature review (SLR) know as PRISMA technique to gather all contemporary researches information from twelve famous publishers and an international index journal. Levitt Diamond model (people, process, technology and organization) will be used to facilitated. The study found several essential factors and the influence of the critical factor into People, Process, Technology and Organization framework. Ultimately, 30 essential factors obtained for Blockchain adoption in SCMS automotive components industry, 3 essential factors impact to People, 20 essential factors impact to Process, 15 essential factors impact to Technology and 9 essential factors impact to Organization..
Advanced Security Model for Internet of Things Environment
Authors:   Department of CSE, Nehru Institute of Engineering and Technology, Coimbatore, India., Mani* Mr. S. , Saravanan* Dr. V. ,   A.P., Department of Computer Science Engg., Dambi Dollo University, Oromia Region, Ethiopia., Lawrence Dr. T. Samraj ,   A.P., Dept. of IT., Dambi Dollo University, Oromia Region, Ethiopia., Sakthidharan Dr. G. R. ,   Professor, Department of CSE, Gokaraju Rangaraju Institute of Engg. & Tech., Hyderabad, India,, Veluchamy Mr. M. ,   Asst. Prof., Department of Computer Science, Periyar University Constituent College of Arts and Science-Idappadi, Salem, India.
Published: April 2020

IoT has become one of the most prominent used industry which is been intensively used in various applications across the globe. This usage has also made it more vulnerable to numerous attacks from within and outside the industry. Though this remains as one of the most predominant challenges in almost all of the industries, most of the organizations fail to allocate security budgets in order to secure their sub-networks from being misused and attacked. One of the most important aspects of this drawback is the unawareness of various upcoming IoT devices and infrastructures that are not technically sound enough to handle and meet the challenges caused by the various attacking methods. Implementation of highly secure IoT based infrastructure could basically produce various other benefits that include obtaining greater revenues from new inculcated methods and models while minimizing the operational costs by making use of the various optimized processes. This, in turn, leads to various meaningful and accurate data with a better knowledge of user experience. In order to develop such an IoT infrastructure, all the organizations have to mandatory build built-in security checks in each and every level of the applications being used by them. The paper presents a new design model that is used for securing all the devices from various malicious attacks. The paper also compares the newly designed model with the existing model and has proved the betterment of the security level that is been achieved.
Object Detection and Classification for Autonomous Drones
Authors:   Computer Science and Engineering Department, SRM Institute of Science and Technology, Kattankulathur, Chennai, India, Ahuja Harit , Kuhar Vedant ,   Computer Science and Engineering Department, SRM Institute of Science and Technology, Kattankulathur, Chennai, India, Minu DR. R.I. ,   Computer Science and Engineering Department, SRM Institute of Science and Technology, Kattankulathur, Chennai, India
Published: April 2020

significantly. This paper aims to implement the state of the art custom algorithm for detection and classification of objects in a single frame with the goal of attaining high accuracy with a real time performance. The proposed system utilizes SSD architecture coupled with MobileNet to achieve maximum accuracy. The system will be fast enough to detect and recognize multiple objects even at 30 FPS.
A Secure Data Transmission in VANETs using HC12
Authors:   Asst. Professor, Dept. of Computer Science and Engineering, K.L.S’s Gogte Institute of Technology, Belagavi, Karnataka, India., Ravi* Kalkundri , Khanai Dr. Rajashri ,   Professor and HOD, Dept. of Electronic & Communication Engineering, KLE Society's College of Engineering & Technology Belgaum, Karnataka, India., Praveen Kalkundri ,   Asst. Professor, Dept. of Electronic & Communication Engineering, K.L.S’s Gogte Institute of Technology, Belagavi, Karnataka, India.
Published: April 2020

Vehicular ad hoc networks (VANETs) is an Intelligent Transportation System and a part of MANETS. VANETs communication is wireless between vehicles and different nodes along the road to increase efficiency and human safety. VANETs embedded all the features of MANETs and almost any Ad Hoc Network. We have discussed various features of VANET and different types of attacks, since the VANET communication is open in nature; they are prone to various types of attacks. Although various attractive features, VANETs also face some challenges like communication with different types of nodes and sensors and gather information or data. Our major focus is on securing this data or information sent by the sender node before transmitting on the network to another node in the network. We intend to solve this by using a wireless LoRa module and cryptography algorithm like ECDH for secure data transmission and solve the security risks and privacy problems. Our work discusses VANET communication method and structure. We provide a simple communication method using P2P topology method and ECDH cryptographic algorithm for keeping the data secure.
A Critical Synthesis Over Natural Fibers, Include Bamboo and Hemp Flavoured with Glass Fiber Reinforced Plastic
Authors:   Production, BPUT, Rourkela, India., Patnaik* Satya Ranjan , Pradhan Manoj Kumar ,   Mechanical, GITA, Bhubaneswar, India,
Published: April 2020

Researchers and academicians are preferably focusing on natural fibers to fabricate in polymer composites for their environmentally friendly and sustainability specialty. The exclusive objective of this review article is to exhibit an inclusive idea of the principal apposite as well as widely used natural fiber reinforced polymer comp osites (NFPCs) and their purposes. Based on the strand class, basis and construction the possessions of NFPCs differ. This work critically synthesizes the exceptional inherent feature of usualstrandstaken in a polymeric matrix as an additive,promotingfabrication of inexpensive and insubstantial composites for weighthandling structures.
Exploring Chatbot Implementation Methodologies used in Customer Support Industry
Authors:   Assistant Professor, Department of Computer Science and Engineering in Sri Krishna college of Technology, Coimbatore, Tamil Nadu, India., E*. T. Suganya., M. , S. Ashwin Kumar N. ,   Department of Computer science and Engineering at Sri Krishna College of Technology, Coimbatore, Tamil Nadu, India., R. Kavijha ,   Department of Computer science and Engineering at Sri Krishna College of Technology, Coimbatore, Tamil Nadu, India.
Published: April 2020

In an IT industry, technical support is a huge sector which requires a lot of manpower and other resources. Although huge organizations have a dedicated group of people working on it, small companies could not afford to have a separate department for managing customer queries. Automation in industry is associated with faster production and cheaper labor costs. By leveraging today's technologies such as Machine learning and Natural Language Processing, the process of handling user’s queries such as complaints about a certain product, feedback, customer experience, and clarifications could be automated using intelligent agents (chatbots) that are able to understand the user's query and assist them accordingly. This process of automating user query handling using chatbots has been the main interest of multiple organizations and would result in saving a lot of resources as well as improve overall customer experience.This paper is a comprehensive exploration of how chatbots have evolved over time and what methodologies are being used to implement these chatbots across different organizations.