bluuebunny/crossref_metadata_2025 huggingface dataset:
Coupled Hydro-Mechanical Behaviour of Rock Joints During Normal and Shear Loading
Authors: Pirzada M. A. , Bahaaddini M. , Andersen M. S. , Roshan H.
Published: November 2022

The hydraulic conductivity of rock joints is an important parameter controlling fluid flow in various rock engineering applications. The shearing and normal loading have significant effects on hydraulic conductivity of rock joints, the property of which is mainly controlled by hydraulic aperture. Despite the importance of hydro-mechanical behaviour of rock joints, the fundamental micro-scale processes leading to macro-scale observations remain unexplored partly due to difficulties with in situ measurement of hydraulic aperture and its complex relation to roughness and contact area. Therefore, in this study, a series of experiments coupling fluid flow with normal deformability and direct shear are performed on joints with varying controlled roughness at different normal stresses. Along with measuring stress and flow rate, the time-lapse X-ray micro-computed tomography is carried out to explore the evolution of joint aperture and contact area during the experiments. The results of the normal deformability experiments show that the joint conductivity is well correlated to the mean hydraulic aperture of joint profiles. Such correlation, however, is not apparent for the shearing experiment where under high normal stresses, the flow rate decreases continually indicating that damaged asperities hinder the fluid flow. Despite the trend in the average mechanical aperture not following the flow rate in some cases, the trend in the contact area follows the flow rate very closely throughout the shearing process. In addition, the results reveal that despite an increase in contact area with increase in normal stress, it is not physically possible to reach full contact even for the artificially well-mated samples at a high normal stress of 10 MPa. Finally, a new correlation is proposed to relate the hydraulic aperture to joint average mechanical aperture, contact area and roughness. The correlation estimates the experimental flow rates at both normal and shear loading conditions with good accuracy.
And the first runner-up is...: comparing winner selection procedures in multi-winner Tullock contests
Authors: Chowdhury Subhasish M. , Mukherjee Anwesha , Turocy Theodore L.
Published: November 2022

We characterise the strategic equivalence among k-winner contests using simultaneous and sequential winner selection. We test this prediction of strategic equivalence using a series of laboratory experiments, contrasting 1-winner contests with 2-winner contests, varying in the latter whether the outcome is revealed sequentially or in a single stage. We find that in the long run, average bidding levels are similar across strategically-equivalent contests. However, adaptation in 2-winner contests is slower and less systematic, which is consistent with the property that simultaneous winner selection results in outcomes that are more random than in the 1-winner case.
Functional extinction of a genus of canopy-forming macroalgae (Cystophora spp.) across Western Australia
Authors: Pessarrodona Albert
Published: November 2022

Declines of canopy-forming macroalgae in response to a variety of anthropogenic stressors are increasingly prevalent in temperate latitudes, with most research efforts focusing on kelp forests. In contrast, comparatively little is known about marine forests formed by fucoid macroalgae, despite them being more diverse and globally widespread. Here, I examine the biogeography of the second-largest genus of fucoids globally (Cystophora), which is endemic to Australasia. To do so, I use a combination of field surveys, records from the literature, anecdotal evidence, and herbaria collections spanning a period of > 150 years. Despite the sampling effort quadrupling in contemporary times, most historically common species were found to be absent or exceedingly rare across their rear (warm) range edge, suggesting their functional extinction. Three species experienced apparent functional contractions across > 250 km of coastline, with some losing approximately 8% of their global distribution. These losses are among the largest reported for any forest-forming species in the Australian continent. Reasons for Cystophora spp. decline are unknown, but likely involve gradual warming, marine heatwaves, and rapid urbanization. Increasing human impacts and further warming in the region threaten several species with further extirpation, some of which are endemic to the area and play unique ecological roles.
Bacteriophage therapy as an alternative technique for treatment of multidrug-resistant bacteria causing diabetic foot infection
Authors: Ghanaim Amira Mohamed , Foaad Mohammed Abdulaziz , Gomaa Eman Zakaria , Dougdoug Khalid Abdelfatah El , Mohamed Gamal Eldidamony , Arisha Ahmed Hamed , Khamis Tarek
Published: November 2022

Diabetic foot ulcer (DFU) represented the most feared diabetic complication that caused the hospitalization of the diabetic patient. DFU was usually characterized with delayed healing as the diabetic neuropathy, angiopathy, and ulcer concomitant infections, among them, are multidrug-resistant (MDR) bacteria that emphasized the clinical importance for developing new therapeutic strategy with safe and effective alternatives for the antibiotics to overcome DFU-MDR bacterial infection. Bacteriophage therapy was considered a novel approach to eradicate the MDR, but its role in the polymicrobial infection of the DFU remains elusive. Thus, the current work was designed to investigate the effect of the topical application of the phage cocktail on the healing of the diabetic wound infected with clinical isolates of Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella variicola, Escherichia coli, and Proteus mirabilis. Bacterial isolation was performed from clinical hospitalized and non-hospitalized cases of DFU, identified morphologically, biochemically, molecularly via 16 s rRNA sequencing, and typed for the antibiotic resistance pattern. Moreover, phages were isolated from the aforementioned clinical isolates and identified with electron microscope. Forty-five adult male Sprague–Dawley rats were assigned in 3 groups (15 rats each), namely, the diabetic infected wound group, diabetic infected wound ceftriaxone-treated group, and the diabetic infected wound phage cocktail-treated group. The results revealed that phage cocktail had a superior effect over the ceftriaxone in wound healing parameters (wound size, wound index, wound bacterial load, and mRNA expression); wound healing markers (Cola1a, Fn1, MMP9, PCNA, and TGF-β); inflammatory markers (TNF-α, NF-κβ, IL-1β, IL-8, and MCP-1); anti-inflammatory markers (IL-10 and IL-4); and diabetic wound collagen deposition; and also the histomorphic picture of the diabetic infected wound. Based on the current findings, it could be speculated that phage therapy could be considered a novel antibiotic substitute in the DFU with MDR-polymicrobial infection therapeutic strategies.
Protocol for the ORION trial (RadiO fRequency ablatION for haemorrhoids): a randomised controlled trial
Authors: Girling C. , Lee M. J. , Vimalchandran D. , Jayne D. J. , Stancliffe S. , Wailoo A. , Bradburn M. , Hind D. , Bursnall M. , Robinson L. K. , Brown S. R.
Published: November 2022

Background

Haemorrhoids are common and can significantly impact the personal and working lives of individuals. Those with more severe symptoms and those not responding to conservative management may require surgery. Current surgical techniques are associated with a degree of postoperative discomfort which may delay return to normal activity. Recurrence is lower in more radical procedures but resulting pain is higher. Radiofrequency ablation (RFA) is a new technique that is gaining popularity and has several hypothesised benefits, including reduced pain and recurrence. However, available evidence is limited. A recent overview from the National Institute for Health and Clinical Excellence recommended more research, in the form of randomised controlled trials, be carried out before further investment is made by national health services. Our aim is to assess whether RFA is at least as good in terms of recurrence as existing surgical interventions, but superior in terms of pain, for patients with symptomatic grade II and III haemorrhoids.

Methods

The RadiO fRequency ablatION for haemorrhoids (ORION) trial will be a pragmatic multicentre patient/assessor-blind parallel group-controlled trial with economic evaluation. The target sample size is 376 participants (188 per arm) and is based on two co-primary endpoints: (i) a non-inferiority design for recurrence and (ii) superiority design for pain at seven days. Participants with grade II or III haemorrhoids will be recruited in 16 National Health Service hospitals and randomised (1:1) to either RFA or surgeon’s choice of surgery.

Conclusions

Results will inform future practice for the treatment of grade II–III haemorrhoids and provide evidence for national health services on future investments in RFA.

Trial registration

ISRCTN14474552.
Statistical evidence and the criminal verdict asymmetry
Authors: Fried Avital
Published: November 2022

Epistemologists have posed the following puzzle, known as the proof paradox: Why is it intuitively problematic for juries to convict on the basis of statistical evidence and yet intuitively unproblematic for juries to convict on the basis of far less reliable, non-statistical evidence? To answer this question, theorists have explained the exclusion of statistical evidence by arguing that legal proof requires certain epistemic features. In this paper, I make two contributions to the debate. First, I establish the Criminal Verdict Asymmetry, a previously-unarticulated asymmetry between the epistemic norms of guilty and not guilty verdicts. I argue that the prosecution and defense’s different epistemic burdens influence whether statistical evidence can generate the type of verdict each side pursues. Second, I point out a mistake in how theorists have understood the role of statistical evidence in criminal trials. Though epistemologists have primarily focused on whether statistical evidence can generate specific epistemic features required for convictions, I consider whether statistical evidence can demonstrate a lack of such features. I find that there are epistemic advantages to allowing the defense to introduce statistical evidence which can reveal the prosecution’s failure to prove the defendant’s guilt.
Non-destructive Evaluation of Workpiece Properties along the Hybrid Bearing Bushing Process Chain
Authors: Fricke Lara Vivian , Thürer Susanne Elisabeth , Kahra Christoph , Bährisch Susanne , Herbst Sebastian , Nürnberger Florian , Behrens Bernd-Arno , Maier Hans Jürgen , Klose Christian , Barton Sebastian
Published: November 2022

To combine the advantages of two materials, hybrid bulk metal workpieces are attractive for subsequent processes such as metal forming. However, hybrid materials rely on the initial bond strength for the effective transfer of applied loads. Thus, a non-destructive evaluation of the bonding along the production process chain is of high interest. To evaluate to what extent non-destructive testing can be employed to monitor the bonding quality between the joining partners steel and aluminum and to characterize the age hardening condition of the aluminum component, ultrasonic testing and electrical conductivity measurements were applied. It was found that a lateral angular co-extrusion process can create homogeneous bonding although the electrical conductivity of the aluminum is altered during processing. A previous bonding before the subsequent die forging process leads to a sufficient bonding in areas with little deformation and is therefore, advantageous compared to unjoined semi-finished products, which do not form a bonding if the deformation ratio is too small. An influence of the subsequent heat treatment on the bonding is not visible in the ultrasonic testing signals though a homogenized electrical conductivity can be detected, which indicates uniform artificial aging conditions of the aluminum alloy
Energy Flux Characterisation of Atmospheric Pressure Plasma Spray Torches with Passive Thermal Probes
Authors: Reck Kristian A. , Hansen Luka , Stummer Maximilian , Kewitz Thorben , Testrich Holger , Hinterer Andreas , Foest Rüdiger , Kersten Holger
Published: November 2022

Passive thermal probes were applied on two different plasma spraying devices to gain a detailed understanding of the energy flux towards the substrate under atmospheric pressure. The challenge of very high thermal load was solved by using an advanced time-resolved measuring and evaluation technique. The combination with a controlled movement of the jets allowed to obtain insightful radial profiles. The energy flux to the substrate changes linearly to the electrical input power. When adding diatomic gases (H2/N2) to the gas mixture the energy flux increases significantly, suggesting a more efficient energy transport. For increasing the axial distance, the energy flux shows a quadratic reduction. The obtained radial profiles are exemplarily utilized to show the inhomogeneous effect of powder injection on the energy flux distribution.
Inhibition of BRD4 enhanced the tumor suppression effect of dasatinib in gastric cancer
Authors: Shen Hao , Hu Xuefei , Yang Xinrui , Chen Jiahui , Fu Yating , He Hongwei , Shi Yongkang , Zeng Rong , Chang Wenjun , Zheng Shangyong
Published: November 2022

BRD4, a member of the bromodomain and extraterminal (BET) family, is elevated in multiple cancer tissues, including gastric cancer (GC). Targeted therapy with BRD4 may help improve the overall survival of patients with GC. Meanwhile, the approved multi-target kinase inhibitor, dasatinib, was recently reported to show varied tumor-suppressive effects in GC cells. This study investigated BRD4 expression in vivo and in vitro using immunohistochemistry and western blotting, respectively. We discussed the relationship between BRD4 expression and patient prognosis. Next, the antitumor efficacy of dasatinib was measured in BRD4-knockdown GC cells to determine the role of BRD4 blockage in dasatinib treatment. Finally, molibresib, a BET inhibitor, was used to measure the cooperative function of BRD4 inhibition and dasatinib treatment in three GC cell lines. Epithelial BRD4 expression was higher in tumoral and metastatic tissues and was strongly associated with unfavorable tumor, node, and metastasis stages and survival. BRD4 expression was heterogeneous in the three GC cell lines tested in vitro. In SGC7901, a BRD4-high GC cell line, knockdown of BRD4 using specific siRNAs suppressed cell growth individually and cooperatively with dasatinib. Moreover, molibresib and dasatinib showed a cooperative effect in suppressing the proliferation of BRD4-high GC cells. In conclusion, we confirmed that increased epithelial BRD4 expression is associated with poor disease stage and prognosis in GC and BRD4 blockage might be a valuable strategy to improve the sensitivity of dasatinib and other drugs in the chemotherapy of advanced GC.
Zeitenwende im arktisch-nordatlantischen Raum. Außen- und sicherheitspolitische Folgen des NATO-Beitritts von Finnland und Schweden
Authors: Ålander Minna , Paul Michael , Swistek Göran
Published: November 2022

Die Zeitenwende ist kein auf Deutschland beschränktes Phänomen. Mit dem Angriffskrieg gegen die Ukraine hat Russland nachhaltige Änderungen in der Außen- und Sicherheitspolitik nordischer Staaten bewirkt. Es ist eine vom russischen Präsidenten provozierte Ironie der Geschichte, dass er in Finnland und Schweden den Beitritt zur NATO bewirkt hat. Der Beitritt ist ein zweischneidiges Schwert: Die beiden Länder tragen zu einer qualitativen Verbesserung der Fähigkeiten zur kollektiven Verteidigung bei, gleichzeitig erweitert sich mit dem Beitritt das Verantwortungsgebiet der NATO deutlich.
Artificial intelligence and machine learning
Authors: Kühl Niklas , Schemmer Max , Goutier Marc , Satzger Gerhard
Published: November 2022

Within the last decade, the application of “artificial intelligence” and “machine learning” has become popular across multiple disciplines, especially in information systems. The two terms are still used inconsistently in academia and industry—sometimes as synonyms, sometimes with different meanings. With this work, we try to clarify the relationship between these concepts. We review the relevant literature and develop a conceptual framework to specify the role of machine learning in building (artificial) intelligent agents. Additionally, we propose a consistent typology for AI-based information systems. We contribute to a deeper understanding of the nature of both concepts and to more terminological clarity and guidance—as a starting point for interdisciplinary discussions and future research.
Equity and Trusts in Australia
Authors: Bryan Michael , Vann Vicki , Barkehall Thomas Susan
Published: November 2022

Equity and Trusts in Australia offers an accessible introduction to the principles of Australian equity and trusts law for students, linking key doctrines to their wider relationship with the law. The text covers foundational topics of equity and trusts law, including the nature of equity, fiduciary relationships and trust structures. This edition has been revised to include recent landmark decisions and a new chapter on termination and variation of trusts. Each chapter concludes with a guide to the online resources, which encourage students to extend their knowledge of the content through further reading, practice problems and discussion topics. Written by a team of experienced authors, Equity and Trusts in Australia is an ideal text for students undertaking this area of study for the first time. A Sourcebook on Equity and Trusts in Australia is also available and provides cases and primary legal materials to accompany Equity and Trusts in Australia.
Branching Brownian motion in a periodic environment and uniqueness of pulsating traveling waves
Authors: Ren Yan-Xia , Song Renming , Yang Fan
Published: November 2022

Using one-dimensional branching Brownian motion in a periodic environment, we give probabilistic proofs of the asymptotics and uniqueness of pulsating traveling waves of the Fisher–Kolmogorov–Petrovskii–Piskounov (F-KPP) equation in a periodic environment. This paper is a sequel to ‘Branching Brownian motion in a periodic environment and existence of pulsating travelling waves’ (Ren et al., 2022), in which we proved the existence of the pulsating traveling waves in the supercritical and critical cases, using the limits of the additive and derivative martingales of branching Brownian motion in a periodic environment.
The European Court of Justice's Transformation of its Approach towards Preliminary References from Member State Administrative Bodies
Authors: BROBERG Morten , FENGER Niels
Published: November 2022

According to Article 267 TFEU, a ‘court or tribunal of a Member State’ can make a preliminary reference to the Court of Justice. The Court applies a single, homogeneous definition of a ‘court or tribunal’. This has allowed it to admit references from those specialised, independent, administrative bodies that in several Member States have been established instead of administrative courts to decide claims under public law, including EU law. Whether such a ‘dispute settling’ body is entitled to submit a preliminary reference normally depends upon whether it commands sufficient ‘independence’ vis-à-vis both the parties to the dispute and the public administration as such. The Court has tightened these requirements appreciably in connection with the threats against the independence of the judiciary in some Member States, and the consequent more prominent roles that Articles 19 TEU and 47 of the Charter have come to play. Whereas safeguarding the rule of law is of utmost importance, these provisions pursue objectives within the Union's legal order which are materially different from those pursued by Article 267. In this article, it is therefore argued that the Court should apply different constructions of the independence criterion with respect to these provisions.
Demographic composition of National Institutes of Health Clinical and Translational Science Awards (CTSA) Program principal investigators, scholars, and trainees
Authors: Rubio Mercedes , Baker Heather L. , Doyle Jamie Mihoko
Published: November 2022

Little has been published on the demographic composition of the clinical and translational science research workforce within the Clinical and Translational Science Awards (CTSA) Program despite the well-documented need for greater diversity in the biomedical research workforce. Analyses of workforce demographic reveal that women and members of underrepresented groups remain persistently underrepresented in the CTSA hub and training components principal investigators. In contrast, in the CTSA Program career development and training programs, females have greater representation as participants, and non-Whites were better represented in training programs.
Paul the Middle Platonist? Exegetical Traditions on Timaeus 28c and the Characterization of Paul in Acts 17:16–31
Authors: Hubbard Jeffrey M.
Published: November 2022

Paul’s speech to the Areopagus in Acts 17 places the apostle in philosophical dialogue with Stoics and Epicureans. This article identifies important points of contact between Paul’s speech and Middle Platonic exegesis of a famous Platonic phrase from Timaeus 28c. There, the philosopher declares that the maker and father of the world is hard to find, and even more difficult to talk about. Many later interpreters of Plato commented on the dictum. Middle Platonists such as Plutarch mused about the theological implications of naming god both “maker” and “father.” Jewish and Christian interpreters like Philo and Justin employed Plato’s phrase to describe their access to divine revelation. The first portion of this article argues that the Areopagus speech contains evidence of similar exegesis, both in its references to god’s roles as maker and father and in Paul’s claim to declare the unknown god. These resonances do more than clarify the author’s philosophical background; they also have previously unexplored implications for our understanding of Paul’s characterization in Acts 17. The second half of the article argues that in aligning Paul with the Platonic tradition, the author participates in an established Greco-Roman practice of depicting the Platonists, Stoics, and Epicureans in theological dialogue.
Beyond the Underdog Mentality: Philo-Semitism amongst Protestant Rescuers in Wartime Ukraine
Authors: Ostapenko Raisa
Published: November 2022

In Ukraine, as was the case across occupied Europe, while most residents of any given locality divided into bystanders, collaborators, and accomplices during the Holocaust, a minority turned to rescue work. Faith-motivated rescue work by large institutions or individuals representing prominent branches of Christianity is well documented; its prevalence exemplifies the critical role that the altruism of individual members of the clergy, laity, and religious orders played in the survival of many Jews. However, rescuers from less prominent denominations of Christianity, amongst them Baptists, Evangelicals, Seventh-day Adventists, and Sabbatarians, are less spoken about, although these rescuers were often equally as motivated to rescue and more poorly resourced to do so due to disadvantageous political circumstances. Some scholars suggest that it was their “underdog” identity that made such groups empathize with persecuted Jews, but primary testimony offers an even more intriguing perspective: it was the philo-Semitic underpinnings of some members of the minority Protestant denominations in question that provided a broad theological basis for rescuing Jews, transcending the sociopolitical phenomenon of the common underdog mentality and even more widespread ecumenical obligations for being a good Christian.
Effect of free-ranging cattle on mammalian diversity: an Austral Yungas case study
Authors: Cuyckens Griet An Erica , Gonzalez Baffa Trasci Noelia Viviana , Perovic Pablo Gastón , Malizia Lucio Ricardo
Published: November 2022

Extensive cattle ranging is an important economic activity in mountains, with diverse effects on native mammal communities. The effects of cattle Bos taurus can be negative, positive or neutral, mostly depending on the stocking rate. We examined the effect of cattle on the diversity and abundance of native mammalian species in the Austral Yungas region of Argentina, considering environmental variables, land protection status, and human influence. Using 12,512 trap-nights from 167 camera-trap stations over 11 years (2009–2019), we calculated a relative abundance index using camera events and used generalized linear models to estimate the effect of cattle on small mammals, large herbivores, species of conservation concern and felids. Cattle had different effects on each group of native mammals. We observed a lower abundance of large native herbivores and the absence of small mammals in areas with high cattle abundance. The tapir Tapirus terrestris, jaguar Panthera onca and white-lipped peccary Tayassu pecari are rare in the Yungas and therefore potentially vulnerable to extinction there. Conservation of small felids and low cattle abundance could be compatible, but felids are threatened by other anthropogenic influences. Native mammalian diversity and richness were related to land protection status. The entire ecoregion is potentially suitable for cattle, suggesting the potential for further threats, and that cattle should be excluded from strictly protected areas. To ensure extensive cattle ranging is compatible with wildlife conservation in areas where exclusion is not possible, we recommend improved management of cattle and moderate stocking rates.
The associations between depressive symptoms, functional impairment, and quality of life, in patients with major depression: undirected and Bayesian network analyses
Authors: Zhou Jia , Zhou Jingjing , Feng Lei , Feng Yuan , Xiao Le , Chen Xu , Yang Jian , Wang Gang
Published: November 2022

Background

Depressive symptoms, functional impairment, and decreased quality of life (QOL) are three important domains of major depressive disorder (MDD). However, the possible causal relationship between these factors has yet to be elucidated. Moreover, it is not known whether certain symptoms of MDD are more impairing than others. The network approach is a promising solution to these shortfalls.

Methods

The baseline data of a multicenter prospective project conducted in 11 governances of China were analyzed. In total, 1385 patients with MDD were included. Depressive symptoms, functioning disability, and QOL were evaluated by the 17-item Hamilton Depression Rating Scale (HAMD-17), the Sheehan Disability Scale (SDS), and the Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-Q-SF). The network was estimated through the graphical Least Absolute Shrinkage and Selection Operator (LASSO) technique in combination with the directed acyclic graph.

Results

Three centrality metrics of the graphical LASSO showed that social life dysfunction, QOL, and late insomnia exhibited the highest strength centrality. The network accuracy and stability were estimated to be robust and stable. The Bayesian network indicated that some depressive symptoms were directly associated with QOL, while other depressive symptoms showed an indirect association with QOL mediated by impaired function. Depressed mood was positioned at the highest level in the model and predicted the activation of functional impairment and anxiety.

Conclusions

Functional disability mediated the relationship between depressive symptoms and QOL. Family functionality and suicidal symptoms were directly related to QOL. Depressed mood played the predominant role in activating both anxiety symptom and functional impairment.
Culture Change in Long-Term Care-Post COVID-19: Adapting to a New Reality Using Established Ideas and Systems
Authors: Iyamu Ihoghosa , Plottel Louis , Snow M. Elizabeth , Zhang Wei , Havaei Farinaz , Puyat Joseph , Sawatzky Richard , Salmon Amy
Published: November 2022

The response to the COVID-19 pandemic in long-term care (LTC) has threatened to undo efforts to transform the culture of care from institutionalized to de-institutionalized models characterized by an orientation towards person- and relationship-centred care. Given the pandemic’s persistence, the sustainability of culture-change efforts has come under scrutiny. Drawing on seven culture-change models implemented in Canada, we identify organizational prerequisites, facilitatory mechanisms, and frontline changes relevant to culture change that can strengthen the COVID-19 pandemic response in LTC homes. We contend that a reversal to institutionalized care models to achieve public health goals of limiting COVID-19 and other infectious disease outbreaks is detrimental to LTC residents, their families, and staff. Culture change and infection control need not be antithetical. Both strategies share common goals and approaches that can be integrated as LTC practitioners consider ongoing interventions to improve residents’ quality of life, while ensuring the well-being of staff and residents’ families.
A deterministic gradient-based approach to avoid saddle points
Authors: Kreusser L. M. , Osher S. J. , Wang B.
Published: November 2022

Loss functions with a large number of saddle points are one of the major obstacles for training modern machine learning (ML) models efficiently. First-order methods such as gradient descent (GD) are usually the methods of choice for training ML models. However, these methods converge to saddle points for certain choices of initial guesses. In this paper, we propose a modification of the recently proposed Laplacian smoothing gradient descent (LSGD) [Osher et al., arXiv:1806.06317], called modified LSGD (mLSGD), and demonstrate its potential to avoid saddle points without sacrificing the convergence rate. Our analysis is based on the attraction region, formed by all starting points for which the considered numerical scheme converges to a saddle point. We investigate the attraction region’s dimension both analytically and numerically. For a canonical class of quadratic functions, we show that the dimension of the attraction region for mLSGD is
$\lfloor (n-1)/2\rfloor$
, and hence it is significantly smaller than that of GD whose dimension is
$n-1$
.
Severe headache in a middle-aged woman after device closure of a ventricular septal defect
Authors: Lee Jungbin , Song Jinyoung
Published: November 2022

Reversible cerebral vasoconstriction syndrome presents with thunderclap headache and represents a group of conditions that show reversible multifocal narrowing of cerebral arteries. Some patients who undergo device closure of an atrial septal defect complain of headache, which are posited as a migraine. Here we report a case of severe headache due not to migraine but reversible cerebral vasoconstriction syndrome after device closure of a ventricular septal defect.
Statues in the French Caribbean and the Iconoclastic Assault
Authors: Gyssels Kathleen
Published: November 2022

This article contributes to debates concerning slavery and slave museums, taking as inspiration historical novels and archives from the Schwarz-Bart Library in Goyave (Guadeloupe). I question, in particular, the passing over of black or mulatto female heroines, in sharp contrast withbékéfigures who, even if they have been temporarily(!) beheaded, remain the more famous icons in the collective mind of the French Caribbean and Caribbean population at large. I could indeed measure that Martinicans, in particular, are proud to have ‘given Napoléon’s wife’ and to have erected her beautiful body into white marble ‘posture’ at the Fort-de-FranceSavanah. My survey touches on the counter-example of ‘La mulâtresse Solitude’, a statue erected in Guadeloupe, but without any indication of its source: the best-selling novelLa mulâtresse Solitudeby André Schwarz-Bart. Why does Édouard Glissant’s project for a ‘Centre national pour la mémoire des esclavages et de leurs abolitions’ on no occasion mention Solitude as the only female heroine such aCentre nationalcould and should have staged? What does this tell us about the gender bias that continues to wreak havoc to the West Indies in all fields? Solitude remains a central, pivotalpoteau mitanin Caribbean iconography. In spite of recent successful innovations, there is still much to sort out before leaving the dominant tendency to ‘statufier sur son sort’ and to promote male heroes instead of female ones.
Humanness as performance
Authors: Barrett John C.
Published: November 2022

If archaeology is the examination of historical conditions with reference to a surviving material residue, then one way in which these conditions might be characterized is as the different ways they had enabled the development of different forms of humanness. The historical construction of this diversity is discussed here as the ways that the relationships between humans and things had been performed. This means that the practice of archaeology must question the recent desire to adopt a flat ontology that defines archaeology as the ‘discipline of things’. It is argued that it was by means of the performances established between humans and their various objects of concern that different forms of human life were able to define themselves. The implications of this argument for the practice of archaeology are explored.
Swift Markov Logic for Probabilistic Reasoning on Knowledge Graphs
Authors: BELLOMARINI LUIGI , LAURENZA ELEONORA , SALLINGER EMANUEL , SHERKHONOV EVGENY
Published: November 2022

We provide a framework for probabilistic reasoning in Vadalog-based Knowledge Graphs (KGs), satisfying the requirements of ontological reasoning: full recursion, powerful existential quantification, expression of inductive definitions. Vadalog is a Knowledge Representation and Reasoning (KRR) language based on Warded Datalog+/–, a logical core language of existential rules, with a good balance between computational complexity and expressive power. Handling uncertainty is essential for reasoning with KGs. Yet Vadalog and Warded Datalog+/– are not covered by the existing probabilistic logic programming and statistical relational learning approaches for several reasons, including insufficient support for recursion with existential quantification and the impossibility to express inductive definitions. In this work, we introduce Soft Vadalog, a probabilistic extension to Vadalog, satisfying these desiderata. A Soft Vadalog program induces what we call a Probabilistic Knowledge Graph (PKG), which consists of a probability distribution on a network of chase instances, structures obtained by grounding the rules over a database using the chase procedure. We exploit PKGs for probabilistic marginal inference. We discuss the theory and present MCMC-chase, a Monte Carlo method to use Soft Vadalog in practice. We apply our framework to solve data management and industrial problems and experimentally evaluate it in the Vadalog system.
The International Court of Justice and the development of international humanitarian law
Authors: Greenwood Christopher
Published: November 2022

Both in its advisory and contentious jurisdiction, the International Court of Justice has made considerable contributions to the evolution and interpretation of international humanitarian law (IHL). The judgments and advisory opinions of the Court in various cases have also developed the regulation of armed conflicts by showing the interplay of other bodies of international law and have shaped the development of non-binding IHL norms. The purpose of this short article is to consider the role of the International Court of Justice in the development of IHL.
New Insights Into Multi‐Component Atmospheric Wet Deposition Across China: A Multidimensional Analysis
Authors: Zhang Qiongyu , Zhu Jianxing , Wang Qiufeng , Xu Li , Li Mingxu , Li Ying , Liu CongCong , He Nianpeng
Published: November 2022

Atmospheric wet deposition has attracted much attention because of its removal function of aerosol particles and impact on ecosystem. It is a complex multi‐component process due to various pollutants emission sources and reaction processes. However, traditional studies mainly focused on single components, ignoring the internal relationships and the comprehensive deposition level; this has hindered the comprehensive understanding and the assessment of ecological effects of deposition. Here, based on the monitoring of wet deposition across 52 stations during 2013–2018 in China, we used two novel multidimensional methods to investigate multi‐component atmospheric wet deposition: network analysis and comprehensive index. Network analysis is a new method that can help better explore the overall relationship between multiple components. We found that due to the improvement of human development level and the diversification of energy sources, the air pollutants sources became more diversified, which reduced the relationship between different deposition components and made the multi‐component deposition network looser. Comprehensive index is a method to realize the fusion of multiple parameters, which can explore the comprehensive effect of multi‐component atmospheric deposition on ecosystems. The high deposition comprehensive index occurred in the central and south China, and mainly influenced by human activities (energy consumption, fertilization, and vehicle ownership) and precipitation, which means that ecosystems in these regions are exposed to greater impacts by wet deposition. The findings provide new insights into understanding multi‐component atmospheric deposition and its comprehensive ecological effects.
The Paris Agreement and Climate Justice: Inequitable Impacts of Sea Level Rise Associated With Temperature Targets
Authors: Sadai S. , Spector R. A. , DeConto R. , Gomez N.
Published: November 2022

Anthropogenic greenhouse gas emissions are causing unprecedented changes to the climate. In 2015, at the United Nations (UN) Conference of the Parties in Paris, France, countries agreed to limit the global mean temperature (GMT) increase to 2°C above preindustrial levels, and to pursue efforts to limit warming to 1.5°C. Due to the long‐term irreversibility of sea level rise (SLR), risks to island and coastal populations are not well encapsulated by the goal of limiting GMT warming by 2100. This review article investigates the climate justice implications of temperature targets in light of our increasing understanding of the spatially variable impact and long temporal commitment to rising seas. In particular we highlight the impact that SLR will have on island states and the role of the Alliance of Small Island States (AOSIS) in UN climate negotiations. As a case study we review dual impacts from the Antarctic Ice Sheet under a changing climate: (a) recent climate and ice sheet modeling shows that Antarctic melt has the potential to cause rapid SLR with a distinct spatial pattern leading to AOSIS nations experiencing SLR at least 11% higher than the global average and up to 33% higher; and (b) future ice sheet melt will result in a negative feedback on GMT, thus delaying temperature rise. When considering these impacts in conjunction, justice concerns associated with the Paris Agreement are exacerbated.
Measuring the Ins and Outflows of Estuaries
Authors: Sidik Saima
Published: November 2022

Scientists modeled monitoring schemes in three different estuaries to determine instrument layouts that could effectively and efficiently measure exchanges of salt water and freshwater.
Simulated Signatures of Greenland Melting in the North Atlantic: A Model Comparison With Argo Floats, Satellite Observations, and Ocean Reanalysis
Authors: Stolzenberger Sophie , Rietbroek Roelof , Wekerle Claudia , Uebbing Bernd , Kusche Jürgen
Published: November 2022

Increased Greenland ice sheet melting has an impact on global mean and regional sea level rise and the ocean circulation. In this study, we explore whether Greenland melting signatures found in ocean model simulations are visible in observations from radar altimetry, satellite gravimetry and Argo floats. We have included Greenland freshwater flux (GF) in the global Finite‐Element‐Sea ice‐Ocean Model (FESOM) for the years 1993–2016. The reference run is computed by excluding Greenland freshwater input. These experiments are performed on a low resolution (ca. 24 km) and a high resolution (ca. 6 km) eddy‐permitting mesh. For comparison with the model experiments, we use different observational data, such as Argo floats, satellite observations, and reanalyses. We find that surface GF maps into signatures in temperature and salinity down to about 100 m in the surroundings of Greenland. The simulated melting signatures are particularly visible in steric heights in Baffin Bay and Davis Strait. Here, we find an improvement of the mean square error of up to 30% when including GF. For the Nordic part of the Nordic Seas, however, we find no improvement when including GF. We compare steric heights with reanalysis data and a new setup of the inversion method from gravimetric and altimetric satellite data. We cannot confirm that the GF signatures on variables such as temperature and salinity are visible in the observations on the time scales considered. However, we find that increased model resolution often causes larger improvements than occur due to including the simulated melting effect.
Systematic Calibration of a Convection‐Resolving Model: Application Over Tropical Atlantic
Authors: Liu Shuchang , Zeman Christian , Sørland Silje Lund , Schär Christoph
Published: November 2022

Non‐hydrostatic km‐scale weather and climate models show significant improvements in simulating clouds and precipitation, especially of convective nature. However, even km‐scale models need to parameterize some physical processes and are thus subject to the corresponding parameter uncertainty. Systematic calibration has the advantage of improving model performance with transparency and reproducibility, thus benefiting model intercomparison projects, process studies, and climate‐change scenario simulations. In this paper, the regional atmospheric climate model COSMO v6 is systematically calibrated over the Tropical South Atlantic. First, the parameters' sensitivities are evaluated with respect to a set of validation fields. Five of the most sensitive parameters are chosen for calibration. The objective calibration then closely follows a methodology previously used for regional climate simulations. This includes simulations considering the interaction of all pairs of parameters, and the exploitation of a quadratic‐form metamodel to emulate the simulations. In the current set‐up with 5 parameters, 51 simulations are required to build the metamodel. The model is calibrated for the year 2016 and validated in two different years using slightly different model setups (domain and resolution). Both years demonstrate significant improvements, in particular for outgoing shortwave radiation, with reductions of the bias by a factor of 3–4. The results thus show that parameter calibration is a useful and efficient tool for model improvement. Calibrating over a larger domain might help to further improve the overall performance, but could potentially also lead to compromises among different regions and variables, and require more computational resources.
Interactions of the Westerlies and Asian Summer Monsoon Since the Last Deglaciation in the Northeastern Qinghai‐Tibet Plateau
Authors: Li Yu , Peng Simin , Hao Lu , Zhou Xueru , Li Haiye
Published: November 2022

The Asian summer monsoon (ASM), controlled by tropical ocean‐atmosphere systems, and the westerlies, directly linked to high‐latitude climates, interact in mid‐latitude East Asia. Located at a climate junction, the northeastern Qinghai‐Tibetan Plateau (QTP) is a sensitive zone for the interaction of the westerlies and ASM. In the current work, we present a new loess data set from the northeastern QTP since the last deglaciation, including grain size, stable isotope (δ13Corg and δ18Ocarb), total organic carbon, total nitrogen, magnetic susceptibility, and mineral composition. The PMIP3‐CMIP5 multi‐model ensemble and TraCE‐21ka transient simulation are used synthetically to analyze climate mechanisms. All proxies suggest instable glacial climate and stable interglacial climate in the northeastern QTP. The coarser grain size during the last deglaciation compared with the Holocene reflects intensified westerlies controlled by the weakening of Atlantic Meridional Overturning Circulation and existing ice sheets. More positive δ18Ocarb values during abrupt cooling events [Heinrich event 1 (H1) and the Younger Dryas (YD)] indicate the effect of a weakened monsoon triggered by the low‐latitude solar insolation and sea surface temperature. Therefore, the anti‐phase pattern between the ASM and westerlies is the primary reason for differences in climate stability. Moreover, low temperature favors the predomination of C3 plants and the development of permafrost, leading to more negative δ13Corg values and fine grain size during the H1 and YD. Taken together, the anti‐phase relationship between the westerlies and ASM emphasizes the complicated dynamic characteristics of atmospheric systems in the mid‐latitudes and the challenges for future predictions.
Multi-organ segmentation of abdominal structures from non-contrast and contrast enhanced CT images
Authors: Yu Cenji , Anakwenze Chidinma P. , Zhao Yao , Martin Rachael M. , Ludmir Ethan B. , S.Niedzielski Joshua , Qureshi Asad , Das Prajnan , Holliday Emma B. , Raldow Ann C. , Nguyen Callistus M. , Mumme Raymond P. , Netherton Tucker J. , Rhee Dong Joo , Gay Skylar S. , Yang Jinzhong , Court Laurence E. , Cardenas Carlos E.
Published: November 2022

Manually delineating upper abdominal organs at risk (OARs) is a time-consuming task. To develop a deep-learning-based tool for accurate and robust auto-segmentation of these OARs, forty pancreatic cancer patients with contrast-enhanced breath-hold computed tomographic (CT) images were selected. We trained a three-dimensional (3D) U-Net ensemble that automatically segments all organ contours concurrently with the self-configuring nnU-Net framework. Our tool’s performance was assessed on a held-out test set of 30 patients quantitatively. Five radiation oncologists from three different institutions assessed the performance of the tool using a 5-point Likert scale on an additional 75 randomly selected test patients. The mean (± std. dev.) Dice similarity coefficient values between the automatic segmentation and the ground truth on contrast-enhanced CT images were 0.80 ± 0.08, 0.89 ± 0.05, 0.90 ± 0.06, 0.92 ± 0.03, 0.96 ± 0.01, 0.97 ± 0.01, 0.96 ± 0.01, and 0.96 ± 0.01 for the duodenum, small bowel, large bowel, stomach, liver, spleen, right kidney, and left kidney, respectively. 89.3% (contrast-enhanced) and 85.3% (non-contrast-enhanced) of duodenum contours were scored as a 3 or above, which required only minor edits. More than 90% of the other organs’ contours were scored as a 3 or above. Our tool achieved a high level of clinical acceptability with a small training dataset and provides accurate contours for treatment planning.