bluuebunny/crossref_metadata_2025 huggingface dataset:
OPTIMALISASI PENGGUNAAN GATE TERMINAL 3 DOMESTIK BANDAR UDARA INTERNASIONAL SOEKARNO-HATTA DI MASA PANDEMI COVID-19
Authors: Rassya Muhammad Hammam
Published: January 2022

Kondisi Pandemi COVID-19 yang terjadi di Indonesia berdampak kepada penurunan jumlah penumpang di bandara. Penurunan ini terjadi karena pembatasan sosial yang berlaku dalam rangka memutus mata rantai penyebaran COVID-19. Penurunan jumlah penumpang juga berdampak kepada penurunan jumlah penerbangan. Sesuai dengan kondisi tersebut, Terminal 3 Domestik Bandar Udara Internasional Soekarno-Hatta perlu melakukan optimalisasi khususnya operasional penggunaan gate karena berhubungan langsung dengan jumlah penerbangan dan penumpang.  Oleh karena itu, dilakukan penelitian untuk mengetahui model optimalisasi penggunaan gate dalam menghadapi Pandemi COVID-19. Dalam penelitian ini menggunakan data primer dan data sekunder. Data primer berupa wawancara yang dilakukan dengan staff landside facility Terminal 3 Domestik dan data sekunder berupa data olahan yang didapat dari pihak PT. Angkasa Pura  II (Persero). Metode yang digunakan adalah metode program linier dengan perhitungan menggunakan program POM-QM for Windows 5. Penelitian ini menggunakan 18 variabel yang berupa frekuensi penggunaan gate dan 39 fungsi kendala (constraints). Hasil penelitian menggunakan metode program linier menghasilkan frekuensi optimal gate digunakan untuk proses boarding penumpang. Ini adalah tiap-tiap frekuensi dari penggunaan gate U11: 528 kali, U12: 932 kali, U13: 1080 kali, U14: 1159 kali, U15: 863 kali, U16: 691 kali, U17: 523 kali, U18: 15 kali, U19: 2266 kali, U20: 545 kali, U21: 0 kali, U22: 197 kali, U23: 5 kali, U24: 84 kali, U25: 0 kali, U26: 163 kali, U27: 0 kali, dan U28: 74 kali. Frekuensi tersebut merupakan penggunaan selama satu tahun situasi pandemi dengan penerapan pembatasan pergerakan masyarakat.
Perencanaan dan Optimasi Penjadwalan Proyek Revitalisasi Masjid Al-Wustho Kota Surakarta Dengan Software Primavera 6.0
Authors: Fachryanto Ranno
Published: January 2022

Tingkat kerumitan dan kompleksitas dalam setiap pembangunan proyek konstruksi bertambah dengan konstan, sehingga melakukan optimasi waktu dan biaya dengan alokasi sumber daya tertentu menjadi hal yang penting. Metode yang dapat berguna untuk mempercepat durasi penyelesaian proyek termasuk dengan menggunakanTime Cost Trade Off (TCTO). Pada Proyek Revitalisasi Masjid Al-Wustho Kota Surakarta, metode yang digunakan untuk mempercepat penyelesaian proyek direncanakan dengan penambahan jam kerja dan penambahan tenaga kerja. Penggunaan software Primavera 6.0 dapat memudahkan proses perencanaan dan penjadwalan. Output yang dihasilkan dari program Primavera 6.0 berupa Gantt Chart, Network Diagram, Critical Path, Resources dan lain sebagainya yang dapat digunakan dalam pengendalian proyek. Dari hasil analisis yang dilakukan diperoleh durasi proyek dengan menambah jam kerja yaitu 131 hari dengan biaya tambahan sebesar Rp 91.531.786,29 sehingga biaya proyek bertambah menjadi Rp 2.985.367.859,79. Sedangkan durasi proyek yang diperoleh dengan menambah jam kerja yaitu 114 hari dengan biaya tambah sebesar Rp 162.312.628,34 sehingga biaya proyek bertambah menjadi Rp 3.056.148.701,84. Sehingga dapat disimpulkan bahwa dengan menggunakan metode penambahan tenaga kerja dapat mengurangi durasi proyek dengan menambah biaya yang lebih banyak dibandingkan dengan metode penambahan jam kerja.
Psychometric Evaluation of the Nursing Child Assessment Teaching (NCAT) Scale in Two Samples of Mothers and Children
Authors:   ,   University of Tennessee Health Science Center, Ransone Samantha
Published: January 2022

The mother-child relationship (MCR) has received an increasing amount of attention over the last several decades regarding its effect on long-term child development. Because the quality and quantity of interactions in the MCR have been established as important predictors of the child’s development, early identification of areas in the relationship requiring support and intervention is essential for promoting positive child outcomes. Observational assessment of the mother and child is considered best practice in evaluating maternal-child interaction (MCI). The Nursing Child Assessment Teaching (NCAT) scale is an instrument that has been used to quantify the quality of interaction in the MCR during the first 36-months of a child’s life. While studies have shown the NCAT scale as both a reliable and valid instrument, limited evidence exists confirming theoretical congruence between the scale and the Barnard Model it is based on. These analyses were conducted using data from two large, demographically different samples, the Nursing Child Assessment Satellite Training (NCAST) database and the Conditions Affecting Neurocognitive Development and Learning in Early Childhood database. Item response theory, confirmatory factor analysis, and multiple indicators multiple causes modeling were used to examine the psychometric properties of the NCAT scale and describe the interactions between mothers and children from these samples. Results of analyses offer support for the Barnard Model and the potential for instrument abbreviation, which may provide researchers and practitioners a more concise, reliable way of measuring MCI. In addition, the predictive validity of both the full NCAT scale and resulting abbreviated NCAT scale (NCAT-AB) was established by obtaining Pearson correlations and associated probabilities for MCI at 12-months, measured by the NCAT and NCAT-AB, and child cognitive and language development at 36-months, as measured by the Bayley Scales of Infant and Toddler Development, Third Edition. This study provided critical appraisal of the NCAT scale, supported the continued use of the NCAT scale in evaluating MCI, and contributed to the growing body of literature surrounding the importance of the MCR on early child development.
Leadership Education Based on the Jamaah Concept in Sayyid Qutb’s Tafsir Fî Zhilâl Al-Qur'ân
Authors: Santi Aji Toto , Yusron Ahmad
Published: January 2022

The sharp controversy among the scholars regarding the jamaah (congregation) concept has become a more interesting side to finding the answer to the truth. This research focuses on uncovering the congregation concept from interpretations drawn to the contemporary atmosphere and Indonesian climate. The method employed in this research discussion was a research library. The content analysis method was a research method that utilized a set of procedures to draw valid conclusions. This study’s findings included the concept of the understanding congregation, the congregation concept in Tafsir (interpretation) Fî Zhilâl al-Qur'ân, and the congregation concept as one leadership unit. This research conclusion is that the congregation phenomenon, according to Qutb, is not only an obligation for Muslims to uphold it in the world but also something that will impact and determine a person's fate in the hereafter.
Freedom, Rights, and Vaccine Refusal: The History of an Idea
Authors: Colgrove James , Samuel Sara J.
Published: January 2022

We analyzed how activists opposed to vaccination have used arguments related to freedom, liberty, and individual rights in US history. We focused on the period from the 1880s through the 1920s, when the first wave of widespread and sustained antivaccination activism in this country occurred. During this era, activists used the language of liberty and freedom most prominently in opposition to compulsory vaccination laws, which the activists alleged violated their constitutionally protected rights. Critics attacked vaccination with liberty-based arguments even when it was not mandatory, and they used the language of freedom expansively to encompass individuals’ freedom to choose their health and medical practices, freedom to raise their children as they saw fit, and freedom from the quasicoercive influence of scientific and medical experts and elite institutions. Evidence suggests that in recent years, vaccine refusal has increasingly been framed as a civil right. We argue that this framing has always lain at the heart of resistance to vaccination and that it may prove consequential for the rollout of COVID-19 vaccines. (Am J Public Health. 2022;112(2):234–241. https://doi.org/10.2105/AJPH.2021.306504 )
US Food Industry Progress Toward Salt Reduction, 2009–2018
Authors: Moran Alyssa J. , Wang Jiangxia , Sharkey Andrea L. , Dowling Erin A. , Curtis Christine Johnson , Kessler Kimberly A.
Published: January 2022

Objectives. To determine the extent to which reductions in sodium during the National Salt Reduction Initiative (NSRI) target-setting period (2009–2014) continued after 2014.

Methods. We used the NSRI Packaged Food Database, which links products in the top 80% of US packaged food sales to nutrition information, to assess the proportion of products meeting the NSRI targets and the sales-weighted mean sodium density (mg/100 g) of 54 packaged food categories between 2009 and 2018.

Results. There was an 8.5% sales-weighted mean reduction in sodium between 2009 and 2018. Most change occurred between 2009 and 2012, with little change in subsequent years. The proportion of packaged foods meeting the 2012 and 2014 targets increased 48% and 45%, respectively, from 2009 to 2012, with no additional improvements through 2018.

Conclusions. Food manufacturers reduced sodium in the early years of the NSRI, but progress slowed after 2012.

Public Health Implications. The US Food and Drug Administration just released 2.5-year voluntary sodium targets for packaged and restaurant food. Continued assessment of industry progress and further target setting by the Food and Drug Administration is crucial to reducing sodium in the food supply.
The 1918 Influenza Pandemic and the Rise of Italian Fascism: A Cross-City Quantitative and Historical Text Qualitative Analysis
Authors: Galofré-Vilà Gregori , McKee Martin , Gómez-León María , Stuckler David
Published: January 2022

Evidence linking past experiences of worsening health with support for radical political views has generated concerns about the consequences of the COVID-19 pandemic. The influenza pandemic that began in 1918 had a devastating health impact: 4.1 million Italians contracted influenza and about 500 000 died. We tested the hypothesis that deaths from the 1918 influenza pandemic contributed to the rise of Fascism in Italy. To provide a “thicker” interpretation of these patterns, we applied historical text mining to the newspaper Il Popolo d’Italia (Mussolini’s newspaper). Our observations were consistent with evidence from other contexts that worsening mortality rates can fuel radical politics. Unequal impacts of pandemics may contribute to political polarization. (Am J Public Health. 2022;112(2):242–247. https://doi.org/10.2105/AJPH.2021.306574 )
Rural–Urban Differences in Influenza Vaccination Among Adults in the United States, 2018–2019
Authors: Jain Bhav , Paguio Joseph Alexander , Yao Jasper Seth , Jain Urvish , Dee Edward Christopher , Celi Leo Anthony , Ojikutu Bisola
Published: January 2022

Objectives. To provide adjusted rates of self-reported receipt of the influenza vaccine in the 2018–2019 flu season among adults in large metropolitan, medium and small metropolitan, and nonmetropolitan areas of the United States by age group, gender, and race.

Methods. We queried the 2019 National Health Interview Survey for respondents aged 18 years and older. To provide national estimates of influenza vaccination coverage, we performed sample-weighted multivariable logistic regressions and predicted marginal modeling while adjusting for age, gender, race/ethnicity, and urban–rural household designation.

Results. After weighting, 48.1%, 46.2%, and 43.6% of adults from large metropolitan, small and medium metropolitan, and nonmetropolitan areas, respectively, received the influenza vaccine. Additionally, there was a trend toward declining influenza vaccination status from large metropolitan to rural areas in all age groups, both genders, and multiple racial/ethnic groups.

Conclusions. Self-reported influenza vaccination rates were lower in rural than in urban areas among adults of all age groups and both genders. Using community leaders for health promotion, augmentation of the community health care workforce, and provision of incentives for providers to integrate influenza vaccination in regular visits may expand influenza vaccine coverage. (Am J Public Health. 2022;112(2):304–307. https://doi.org/10.2105/AJPH.2021.306575 )
West Oakland’s Experience in Building Community Power to Confront Environmental Injustice Through California’s Assembly Bill 617
Authors: MacIver Lily , London Jonathan , Sampson Natalie , Gordon Margaret , Grow Richard , Eady Veronica
Published: January 2022

We explored how air quality management processes associated with Assembly Bill 617 (AB 617) in West Oakland, California, represent a shift in power relationships between government agencies and communities toward the goal of addressing legacies of environmental injustice.

We drew from a statewide assessment of community engagement in AB 617’s first year, and an analysis of the West Oakland AB 617 process. The first comprised 2 statewide surveys (n = 102 and n = 106), 70 key informant interviews, observation of all AB 617 first-year sites, and analysis of related planning documents. The second comprised 2 rounds of interviews (n = 22 and n = 23, with a total of 19 individuals) and extensive participant observation.

Several factors are necessary for pursuing environmental justice: (1) invest in community partnerships and collaborations, (2) honor community knowledge and data, (3) ensure that community constituents share power in environmental governance, and (4) adopt explicit racial justice frameworks. Although still a work in progress, AB 617 offers important lessons for community and policy organizations nationwide engaged in environmental justice. (Am J Public Health. 2022;112(2):262–270. https://doi.org/10.2105/AJPH.2021.306592 )
The Dangers of White Supremacy: Nazi Sterilization and Its Mixed-Race Adolescent Victims
Authors: Weindling Paul
Published: January 2022

Mixed-race African German and Vietnamese German children were born around 1921, when troops drawn from the French colonial empire occupied the Rhineland. These children were forcibly sterilized in 1937. Racial anthropologists had denounced them as “Rhineland Bastards,” collected details on them, and persuaded the Nazi public health authorities to sterilize 385 of them. One of the adolescents later gave public interviews about his experiences. Apart from Hans Hauck, very few are known by name, and little is known about how their sterilization affected their lives. None of the 385 received compensation from the German state, either as victims of coerced sterilization or as victims of Nazi medical research. The concerned human geneticists went unprosecuted. (Am J Public Health. 2022;112(2):248–254. https://doi.org/10.2105/AJPH.2021.306593 )
Imaging Follow-up of Pediatric Transphyseal Anterior Cruciate Ligament Reconstruction
Authors: Maupoint Estelle , Vial Julie , Simon Sophie , Gauthier Léa , Accadbled Franck
Published: January 2022

Case:

We are reporting on the x-ray and magnetic resonance imaging (MRI) follow-up of an 8-year-old boy who underwent transphyseal anterior cruciate ligament reconstruction with a 4-strand semitendinosus tendon graft. His graft was followed for 5 years by MRI, demonstrating a satisfactory but slow and gradual ligamentization process.

Conclusion:

The long-term MRI follow-up demonstrated the satisfactory outcome of the transphyseal reconstruction, although with a slower and more progressive ligamentization process than in adult patients.
Benefits of Hypnotherapy on Interest in Learning for Grade VI Elementary School Students
Authors: Nihayah Lilis , Retnani Wahyu
Published: January 2022

Interest in learning in a student plays an important role that has an impact on behavior and attitudes. While the role of interest in the learning process is to concentrate thoughts and create its own pleasure. Hypnotherapy is one method that can be used as a means of reprogramming the subconscious mind, in order to provide positive learning suggestions. The purpose of this hypnotherapy is to improve the learning of sixth graders at SDN Tenggulunan. The hypnotherapy process itself is carried out with various techniques in order to reach the subconscious mind. Because the subconscious mind has an influence as much as 88% compared to the conscious 12%. Interest has elements of cognitive, emotional, effective. The data obtained before in the field is the very broad benefits of hypnotherapy, then when in the field the process of implementing hypnotherapy is carried out several times so that the suggestions given can have the expected results. After implementation in the field, the results of changes are not only based on academic values, but include emotions, effectiveness. So that when the implementation of hypnotherapy is successful, in the subconscious mind, how to solve an obstacle.
Mind Mapping Method To Reduce Anxiety Ahead Of The Exam In Sociology Subjects
Authors: Novianto Muhammad Haris , Nastiti Dwi
Published: January 2022

Mind mapping methods facilitate the students to recognize the course material in the form of keywords, symbols, images and colored lines. The purpose of this study was to determine the effect of mind mapping method to students' anxiety towards sociology examination. This study used a quantitative experiment approach with nonrandomized pretest-posttest control group design. Variables in this study were a mind mapping method as an independent variable (X) and students' anxiety towards sociology examination as a dependent variable (Y). Cluster random sampling was used as the sampling technique which class-XD as experimental group and Class-XA as the control group. Uncorrelated data/independent sample t-test was used to analyze data which calculated with SPSS 16.0 for Windows, the result showed (t=3.278; ρ = 0.002; ρ<0.05), it means there are differences of students' anxiety toward sociology examination to students who use the mind mapping methods that do not use the mind mapping method.
Application of LiDAR-Derived Data using Multi-Criteria Evaluation (MCE) and Stochastic Modelling; A Flood Risk Analysis of the Mersey River, Nova Scotia
Authors: Nieto Alejandro , Almuina Pica Daniel Elliot , Stange Tyler
Published: January 2022

The Maritime province of Nova Scotia has seen coastal flooding become a more frequent phenomenon during the past decades due to the changing climate regime. This has influenced the interest provincial and federal governments have in flood risk modelling, who often incorporate Geographic Information Systems (GIS) as useful tools in their analysis. Incorporating LiDAR-derived digital elevation models (DEMs) in their workflows is the next step in hydrological analysis, as LiDAR-derived DEMs offer high resolution data for the analysis of flood risk without the need to rely on biotic or hydrological data. This study aims to follow this theme in order to model the effects of inland flooding in the low relief landscape of the Mersey River, located in Queen’s County, Nova Scotia, and its effects on the infrastructure built along the river network. The analysis included multi-criteria evaluation (MCE) methods coupled with a stochastic simulation approach in order to determine areas where vulnerability is the most certain. Results indicated that high flood risk is present in urbanized areas within 1 km of the Mersey River at a low degree of uncertainty, making them the best candidates for flood-preventive measures. The accuracy provided by LiDAR-derived DEMs supported a high-quality workflow for the MCE and DEM error analysis, proving their utility for floodplain delineation. The addition of historical and hydrological data to future projects could build on the results presented in this study, adding more to the literature on flood risk modelling along the Mersey River.
A CEEMD-ARIMA-SVM Model with Structural Breaks to Forecast the Crude Oil Prices Linked with Extreme Events
Authors: Cheng Yuxiang , Yi Jiayu , Yang Xiaoguang , Lai Kin keung , Seco Luis
Published: January 2022

This paper develops an integrated framework to forecast the volatility of crude oil prices by considering the impacts of extreme events (structural breaks). The impacts of extreme events are vital to improving prediction accuracy. Aiming to demonstrate the crude oil price fluctuation and the impacts of external events, this paper employs the Complementary Ensemble Empirical Mode Decomposition (CEEMD). It decomposes the crude oil price into some constituents at various frequencies to extract a market fluctuation, a shock from extreme events, and a long-term trend. The shock from extreme events is found to be the most crucial element in deciding the crude oil prices. Then we combine the Iterative Cumulative Sum of Squares (ICSS) test with the Chow test to get the structural breaks and analyze the extreme event impacts. Finally, this paper combines the structural breaks, the Autoregressive Integrated Moving Average model (ARIMA), and the Support Vector Machine (SVM) to make a forecast of the crude oil prices. The empirical process proves that the CEEMD-ARIMA-SVM model with structural breaks performs the best when compared with the other ARIMA-type models and SVM-type models. The framework offers an insightful view to help decision-makers and can be used in many areas.
CENP-N promotes the compaction of centromeric chromatin
Authors: Luger Karolin , Zhou Keda , Gebala Magdalena , Woods Dustin , Sundararajan Kousik , Edwards Garrett , Krzizike Daniel , Wereszczynski Jeff , Straight Aaron
Published: January 2022

The histone variant CENP-A is the epigenetic determinant for the centromere, where it is interspersed with canonical H3 to form a specialized chromatin structure that nucleates the kinetochore. How nucleosomes at the centromere arrange into higher order structures is unknown. Here we demonstrate that the CENP-A interacting protein CENP-N promotes the stacking of CENP-A containing mono-nucleosomes and nucleosomal arrays through a previously undefined interaction between the α6 helix of CENP-N with the DNA of a neighboring nucleosome. We describe the cryoEM structures and biophysical characterization of such CENP-N mediated nucleosome stacks and nucleosomal arrays and demonstrate that this interaction is responsible for the formation of densely packed chromatin at the centromere in the cell. Our results provide first evidence that CENP-A, together with CENP-N, promotes specific chromatin higher order structure at the centromere.
Energy demand reduction options for meeting national zero emission targets
Authors: Barrett John , Pye Steve , Betts-Davies Sam , Broad Oliver , Price James , Eyre Nick , Anable Jillian , Brand Christian , Bennett George , Carr-Whitworth Rachel , Garvey Alice , Giesekam Jannik , Marsden Greg , Norman Jonathan , Oreszczyn Tadj , Ruyssevelt Paul , Scott Kate
Published: January 2022

Energy Demand Reduction (EDR) refers to lowering the amount of energy required to provide energy services across mobility, shelter, nutrition or the production of goods and services, among others, with the goal of reducing greenhouse gas emissions. In recent years, global studies have attempted to understand the contribution EDR could make to climate mitigation efforts. Whilst these studies are important to build a global picture, climate targets and policy are necessarily devised at the national level. To address this disconnect, we develop a bottom-up, whole system framework that comprehensively estimates the potential for energy demand reduction at a country level. Replicable for other countries, our framework is applied to the case of the UK where we find that reductions in energy demand of 52% by 2050 compared with 2020 levels are possible without compromising on citizens’ quality of life. This translates to annual energy demands of 40GJ per person, compared to the current OECD average of 55GJ. Our findings show that EDR can reduce reliance on high-risk carbon dioxide removals, moderate investment requirements, and allow space for ratcheting up climate ambition. We conclude that national climate policy should increasingly develop and integrate EDR measures to both articulate national ambition and feeding into international pledges through Nationally Determined Contributions.
Effect of Tellurium Doping on Optoelectronic Properties of Blue ZnTeSe Quantum Dots
Authors: Jang Eunjoo , Kim Taehyung , Chung Heejae , Choi Seon-Myeong , Won Yu-Ho , Lee Jae-Yong
Published: January 2022

Quantum dot light emitting diodes (QD-LEDs) have high potential to be used in next-generation displays. The main challenge in the commercialisation of QD-LEDs is the improvement of the efficiency and stability of blue QD-LEDs. The most promising emitter for blue QD-LEDs is ZnTeSe QD, however it is concerned that tellurium causes spectral broadening and efficiency drop. In this work, we demonstrate the effect of Te clusters on the electronic structures of blue ZnTeSe QDs through first principle calculation. The photo dynamics at the ensemble and single dot level show that the lifting of hole-state degeneracy in Te-doped structures causes slow relaxation and peak emission shift. Furthermore, the strong confinement of hole wave functions in Te clusters improves the efficiency and stability of QD-LEDs by suppressing QD luminescence quenching under electrical bias. The understanding of the correlation between the photophysical nature of Te-doped QDs and device performance can provide a basis for designing blue-emitting QD structures that are suitable for practical QD-LEDs.
Papaver Decaisnei: GC-MS Alkaloids Profiling, in Vitro Antioxidant, and Anticancer Activity
Authors: kamaran
Published: January 2022

The Papaver L. plant have been well known as a source of pharmaceutically valuable alkaloids (noscapine, thebaine, codeine, roemerine, papaverine and morphine). The current study investigates the phytochemical, in-vitro antioxidant, and anticancer activities of papaver decaisnei, an endemic plant species to the flora of Kurdistan-Iraq. The chemical analysis of the methanolic (MeOH) extracts of flowers, leaves, and roots of papaver decaisnei were made by using gas chromatography-mass spectrophotometry (GC-MS), and the antioxidant activity evaluation done by radical scavenging [on 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2jazino-bis (3- ethylbenzothiazoline-6-sulfonic acid) (ABTS)], and reducing power [cupric reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP)] assays. The anticancer actions were presented as IC50 (inhibitory concentration at 50%) on human colorectal adenocarcinoma (Caco-2), mammary cancer cells (MCF-7), and human cervical carcinoma (HeLa) cells. The results of the phytochemical analysis showed 17, 19, and 22 chemical compounds for flowers, leaves, and roots of P. decaisnei, respectively. The prevalent organic compounds of P. decaisnei were alkaloids, phenolics, fatty acids, esters, and phytosterols, namely Roemerine (70.44%), Decarbomethoxytabersonine, 9,12,15- Octadecatrien-1-ol, Hexadecanoic acid, 6,8-Dioxa-3-thiabicyclo(3,2,1)octane 3,3-dioxide, and γ-Sitosterol. The antioxidant activity of plant organ extracts was within 39.1-143.5 μg/ml for DPPH and 123.12-276.4 μg/ml for ABTS assays, while, the FRAP and CUPRAC values ranged within 12.4- 34.3 and 42.6-75.8 μg/ml, respectively. The anticancer action of P.decaisnei organ extracts was found against all tested human cell lines (Caco-2, MCF-7, HeLa) with inhibitory concentrations (IC50 ) values between 125.3-388.4 μg/ml. The presented data on alkaloid contents and biological activity of P. decaisnei can serve a ground knowledge for the future biomedical synthesis and cancer research projects.
Ultrastrong, Highly Conductive and Capacitive Hydrogel Electrode for Electron-ion Transduction
Authors: Yao Bowen , Yan Yichen , Cui Quincy , Duan Sidi , Wang Canran , Du Yingjie , Zhao Yusen , Wu Dong , Wu Shuwang , Zhu Xinyuan , Hsiai Tzung , He Ximin
Published: January 2022

Electron-ion transduction is the cornerstone for electronic devices interfacing with biological organisms and promoting emerging ionotronic devices, ranging from basic electronic elements to wearable electronics and energy harvesting devices. However, with commonly used metal electrodes, the electron-ion transduction suffers from high impedance, signal distortion and poor voltage tolerance. Surface modification with conductive porous materials could partially remedy these issues but is inevitably accompanied by weak interfacial adhesion and mechanical weakness. Therefore, freestanding electrodes integrating high mechanical and electrical properties are highly demanded. Herein, a general strategy is discovered to ameliorate these issues by introducing a conducting polymer (CP) hydrogel electrode of ultrahigh strength (~30 MPa) and conductivity (up to ~1200 S cm−1) with a capacitive behavior. These features are derived from the conductive nanoporous matrix with π-π interactions as both crosslinking sites and electron-transfer pathways, through surface gelation coupled with secondary-doping and densification. This strategy significantly decreased the low-frequency impedance and improved the signal fidelity, without affecting its high-frequency response. Furthermore, excellent biocompatibility, multifunctionality, and heart pacing upon ultra-low voltage (60% reduction) have also been demonstrated, showing the great potential of this CP material for bioelectronic applications and various human-machine interfaces.
WITHDRAWN: Integrative Analysis of the Proteome and Transcriptome in Gastric Cancer Identified Membrane Protein LRP1B as a Potential Biomarker
Authors: Miao Ji , Yang Zhi , Guo Wen , Liu Lixiang , Song Peng , Ding Chao , Guan Wenxian
Published: January 2022

Background: Membrane proteins participate in cell recognition and malignant transformation, and have value in terms of tumor detection and therapy. The aim of this study was to discover unique membrane proteins for gastric cancer (GC) with proteomic analysis of cell lines.Methods: Using the data-independent acquisition (DIA) strategy, we compared the relative expression levels of membrane proteins between GC and noncancer cells. Promising candidates were identified by matching proteomic data to The Cancer Genome Atlas (TCGA) GC transcriptional profiles, and then accessed their expression using immunohistochemistry.Results: Based on about 4700 membrane proteins quantified, 2774 differentially expressed membrane proteins were identified between GC and normal cell lines. Molecular function analysis indicated that these abnormally expressed proteins were mainly involved in biological metabolic processes. Conjoint analysis of transcriptomes and proteomes provided 11 potential biomarkers (GPRC5A, PSAT1, NUDCD1, RCC2, IPO4, FAM91A1, KANK2, PRADC1, NME4, METTL7A and LRP1B) for further exploration. The downregulation of LRP1B in GC was validated by immunohistochemistry on 66 matched pairs of normal and GC tissues.Conclusions: These data provide a comprehensive overview of the proteomic phenotypes of membrane proteins in GC tumorigenesis. Based on the integrative analysis, LRP1B was identified as a meaningful indicator assisting in GC diagnosis and molecular detection.
WITHDRAWN: Non-Uniform Diffraction Pattern of Grating Experiments---Rotating Grating Around Three Axes (3)
Authors: peng hui
Published: January 2022

The orientation-dependence of the interference/diffraction patterns of the 1D-double slit, 2Dcross-double slit, 1D-grating and 2D-cross-grating experiments have been studied experimentally andtheoretically. The universal phenomena of the curved, expanded, inclined and mirror-symmetricpattens were reported. However, the above experiments were limited to certain orientations, namelyrotating the diaphragm/grating around either one axis or two axes. Here we show that, for certainorientations by rotating the grating around 3 axes, the spacings between adjacent diffraction orders arenon-uniform. Namely, from “one end” of the pattern to “other end”, the spacings between adjacentdiffraction orders gradually increase. This extraordinary phenomenon challenges the existing theories.The above observed phenomena provide the comprehensive phenomena to theoretical study of thegrating experiments. We suggest that the complete mathematical model should contain three rotationangles as parameters and should be able to describe the phenomena of the non-uniform-spacing,curved, expanded, inclined and mirror-symmetric diffraction patterns consistently.
Prunus persica apoplastic proteome analysis reveals candidate proteins involved in the resistance and defense against Taphrina deformans
Authors: Butassi Estefanía , Novello María Angelina , LARA MARIA VALERIA
Published: January 2022

The first Prunus persica apoplastic proteome analysis was assessed by LC-MS/MS. 365 proteins were identified and molecular/biological function classified.
Taphrina deformans in the pathogenic fungus responsible for the leaf peach curl disease.
To gain insight into the molecular mechanisms involved in plant resistance and response to the fungus, apoplastic differentially abundant proteins (DAPs) in a resistant (DR) and/or in a susceptible genotype (FL) were identified after 12 and 96 hours post inoculation (hpi) and compared to those at 0 hpi. In both genotypes, major changes occurred at 96 hpi when the fungus had achieved the filamentous form. However, at 96 hpi, DR exhibited a greater number of increased proteins than FL. DAPs were enriched in biotic stress response, with most of the proteins belonging to the pathogenesis related (PR)-type. PRs exhibited the greatest fold changes of induction in DR. While PRs acting on pathogen cell wall (PR2, PR3 and PR4) were increased in both susceptible and resistant genotypes, others were exclusively induced in DR as PR5, defensin and PR17. Proteins exclusively induced in DR upon T. deformans inoculation such as a dirigent protein, three berberine bridge enzymes, a glyoxal oxidase-related, two snakins and a GDS-lipase were identified. Moreover, upon inoculation cuticle was thickened to a greater extent in DR than in FL. This work reveals the active role of the apoplast against T. deformans and not only contributes to the elucidation of the responses involved in resistance to leaf curl disease but also improves knowledge on peach defenses against pathogens.
Transparency in conducting and reporting research: a survey of authors, reviewers, and editors across scholarly disciplines
Authors: Malički Mario , Aalbersberg IJsbrand Jan , Bouter Lex , Mulligan Adrian , Riet Gerben ter
Published: January 2022

Calls have been made for improving transparency in conducting and reporting research, improving work climates, and preventing detrimental research practices. To assess attitudes and practices regarding these topics, we sent a survey to authors, reviewers, and editors. We received 3,659 (4.9%) responses out of 74,749 delivered emails. We found no significant differences between authors’, reviewers’, and editors’ attitudes towards transparency in conducting and reporting research, or towards their perceptions of work climates. Undeserved authorship was perceived by all groups as the most prevalent detrimental research practice, while fabrication, falsification, plagiarism, and not citing prior relevant research, were seen as more prevalent by editors than authors or reviewers. Overall, 20% of respondents admitted sacrificing the quality of their publications for quantity, and 14% reported that funders interfered in their study design or reporting. Our results indicate that greater involvement of all stakeholders is needed to align actual practices with current recommendations.
Technological learning potential of offshore wind technology and underlying cost drivers
Authors: Santhakumar Srinivasan , Heuberger-Austin Clara , Meerman Hans , Faaij André
Published: January 2022

Detailed analysis of technological learning of energy technologies is scarce. For floating wind, this is missing altogether. In this study, we applied experience curve and bottom-up cost modeling methodologies and assessed the long-term cost reduction potential of fixed-bottom and floating offshore wind in their mature markets. The contributing factors to cost reduction are also quantified and elaborated. Further, to emphasize the role of strongly varying site characteristics of offshore wind farms and their influences, the grid connection cost is separately discussed from the total technology costs (Capital Expenditure and LCoE). Our assessment shows that, excluding grid connection costs, fixed-bottom offshore wind LCoE is 40 €/MWh at 31 GW cumulative capacity (2023–2024) and decline to 28 ± 3 €/MWh by 100 GW. Floating wind LCoE is 123 €/MWh at 1 GW cumulative capacity (2027 – 2030) but decline to 33 ± 6 €/MWh by 100 GW. Moreover, floating wind can achieve cost parity (i.e., 40 €/MWh, excl. grid connection cost) by deploying 21 GW, requiring 44 billion € of learning investment in the form of subsidies to compensate the price gap for the technology in the energy system. Lastly, we analyzed the grid connection costs and their influencing factors, and then determined that an integrated offshore grid would be needed to efficiently connect future offshore wind farms to the onshore grid.
Euxinic versus ferruginous anoxia before and during the Toarcian Oceanic Anoxic Event
Authors: Kunert Alexandra , Kendall Brian
Published: January 2022

Mesozoic oceanic anoxic events are recognized as widespread deposits of marine organic-rich mudrocks temporally associated with mass extinctions and large igneous province emplacement. The Toarcian Oceanic Anoxic Event (T-OAE) is one example during which expanded ocean anoxia is hypothesised in response to environmental perturbations associated with emplacement of the Karoo–Ferrar igneous province. However, the global extent of total seafloor anoxia and the relative extent of ferruginous (anoxic and Fe2+-rich) versus euxinic (anoxic and H2S-rich) conditions during the T-OAE and other Mesozoic OAEs are poorly constrained. Here we present new estimates of the global anoxic and euxinic seafloor area before and during the T-OAE based on rhenium and molybdenum enrichments in organic-rich mudrocks of the Fernie Formation (British Columbia, Canada). Trace metal concentrations and ratios, together with high organic carbon contents, indicate that this previously unstudied locality was minimally restricted from global ocean circulation, experienced deep-water nutrient upwelling, and had O2-deficient bottom waters. Pronounced rhenium and molybdenum enrichments in mudrocks deposited from locally anoxic and euxinic waters, respectively, point to large global oceanic reservoirs of these metals. Mass balance models suggest that the T-OAE likely comprised a modest expansion of up to ~7% anoxic seafloor dominated by euxinia. Hence, anoxic seafloor was likely confined to epicontinental seaways, semi-restricted basins, and continental margin oxygen minimum zones during the T-OAE.
From schwertmannite to natrojarosite: Long-term stability and kinetic approach
Authors: Jiménez Amalia , Marban Gregorio , Roza-Llera Ana
Published: January 2022

This work examines the transformation of iron-bearing precursors to jarosite-like minerals in the absence of bacteria or other organic compounds. The composition of the aqueous solution determines the transformation, through which crystallinity and long-term stability of jarosite increase, whereas the temperature of the environment affects the kinetics of the process. Spectroscopic techniques (FTIR and XPS) were used to characterize the chemical species present on the transformed mineral surfaces. Schwertmannite is the first phase to precipitate as a result of homogeneous nucleation and growth in the bulk of the supersaturated solution. This metastable phase transforms into a crystalline Na-rich member of the (Na,H3O)Fe3(SO4)(OH)6 solid-solution family after aging for either 3 h at 70 °C or 1 day at 20 °C. XRD analyses show that the crystallinity of natrojarosite increases progressively with reaction time, although its cell parameters and crystallite size remain nearly constant during aging, which reveals the stability of the crystal structure of this secondary phase. Interestingly, the mechanisms governing the transformation from aggregates of schwertmannite into natrojarosite crystals consist of interface-coupled dissolution–precipitation reactions that involve an internal structural reorganization within the individual nanoparticles of the secondary phase, in which Fe3+ is transferred from the solid to the solution while SO42−, OH–, and Na+ move in the opposite direction. The spectroscopic study confirms the mineralogical results and suggests that the crystal structure of jarosite-like minerals may offer interesting geochemical information about the aqueous solutions where they were formed. The transformation kinetics and the apparent activation energy (Ea = 52.1 kJ/mol) of the transformation were estimated using the so-called “time to a given fraction” method, and a temperature-transformation-time (TTT) diagram was established in the range 20–70 °C to define the reaction pathways during the process.
Textural and chemical evolution of magnetite from the Paleozoic Shuanglong Fe-Cu deposit: Implications for tracing ore-forming fluids
Authors: Zhang Shuanliang , Chen Huayong , Xiao Bing , Zhao Liandang , Hu Xia , Li Jianping , Gong Lin
Published: January 2022

The Aqishan-Yamansu belt in Eastern Tianshan (NW China) hosts several important Fe and Fe-Cu deposits, the origin of which is the subject of considerable debate. The coexistence of various types of ore-forming fluids makes it difficult to distinguish the genesis of the Fe-Cu deposits. We present detailed textural and compositional data on magnetite from the Paleozoic Shuanglong Fe-Cu deposit to constrain the formation of iron oxides and the evolution of the ore-forming fluids and thus define the genesis of the Fe-Cu ores.

Based on the mineral assemblages and crosscutting relationships of veins, two mineralization stages were established, including the early Fe mineralization and late Cu mineralization stage. Three types of magnetite, i.e., platy (MA), massive (MB), and granular (MC) magnetite occur in the Fe mineralization. Backscattered electron (BSE) images identified display oscillatory zoning in an early hematite and transformational mushketovite phase (MA-I), characterized by abundant porosity and inclusions, as well as two later generations, including an early dark (MA-II, MB-I, and MC-I) and later light magnetite (MA-III, MB-II, and MC-II). The MA-I has extremely high W contents and mostly displays as micro- and invisible scheelite inclusions, which were probably caused by the W expulsion during mushketovitization. The texture and composition of magnetite suggest that the later light magnetite formed via dissolution and reprecipitation of the precursor dark magnetite, and the temperature and oxygen fugacity of fluids decreased over time. Our study also shows the MB-II magnetite and coexisting chlorite display synchronous oscillatory zoning, with the calculated temperature from 444 to 212 °C. Such variations could indicate the incursion of external low-temperature fluids with high salinity, which can dissolve the primary dark magnetite. This study provides a good example of using magnetite to trace the complex evolution and multiple sources of ore-forming fluids.
Spiking neuromorphic chip learns entangled quantum states
Authors: Czischek Stefanie , Baumbach Andreas , Billaudelle Sebastian , Cramer Benjamin , Kades Lukas , Pawlowski Jan M. , Oberthaler Markus , Schemmel Johannes , Petrovici Mihai A. , Gasenzer Thomas , Gärttner Martin
Published: January 2022

The approximation of quantum states with artificial neural networks has gained a lot of attention during the last years.
Meanwhile, analog neuromorphic chips, inspired by structural and dynamical properties of the biological brain, show a high energy efficiency in running artificial neural-network architectures for the profit of generative applications.
This encourages employing such hardware systems as platforms for simulations of quantum systems.
Here we report on the realization of a prototype using the latest spike-based BrainScaleS hardware allowing us to represent few-qubit maximally entangled quantum states with high fidelities.
Bell correlations of pure and mixed two-qubit states are well captured by the analog hardware, demonstrating an important building block for simulating quantum systems with spiking neuromorphic chips.
Impact of the COVID-19 pandemic on bank efficiency in Vietnam
Authors: Minh Sang Nguyen
Published: January 2022

Banking system is an important part of the financial system of each country. The operating efficiency in the commercial banking system will provide the tools and financial products more attractive and relevant to the needs of actors in the economy. The purpose of this paper is to analyze the impact of COVID-19 on the efficiency of 26 Vietnamese commercial banks. The paper uses a quantitative method with the nonparametric frontier analysis, data envelopment analysis (DEA) approach, to measure the efficiency of Vietnamese commercial banks. The paper adopts an intermediation approach as the banks are viewed as financial intermediaries providing financial services and payment services to entities in the economy. Research findings reveal that Vietnamese commercial banks have effectively leveraged the positive impacts of the COVID-19 pandemic, since the average efficiency in 2020 improved over the pre-pandemic period in 2019 on the same models for comparison and estimation. Based on such findings, the study makes some suggestions and recommendations to help Vietnamese commercial banks increase their operational efficiency in the context of the prolonged pandemic.
AcknowledgmentThe author wishes to acknowledge support from the Banking University – Ho Chi Minh City. This research was made possible thanks to all valuable support from relevant stakeholders.
Business model for integrated sustainable value creation: A supply chain perspective
Authors: Koilo Viktoriia
Published: January 2022

In the context of globalization, the process of value creation is becoming more complex, exposed to greater risks for companies, partners, and customers. Moreover, modern digital technologies, such as the use of digital twin technology, can increase the use of geographically dispersed work teams and contribute to sustainable value creation in the future. However, the digital transition creates new organizational models and influences relationships in supply chains, thus affecting structural changes in business models.Hence, the study aims to investigate, from the whole value chain perspective, how the next generation of digital services is affecting business value and changing the business model concept. In addition, this paper discusses the stakeholder and social responsibility value creation perspective on business model for integrated sustainable value creation. To investigate this, it was decided to use a quantitative methodology in the form of questionnaires, which were distributed among different interested parties: two contractors, three suppliers, and an operator. The results indicated that all respondents, such as an operator, shipping companies, and subsea service providers, are positive about future digital technologies, which should ensure environmental sustainability, improve human interaction and communication. At the same time, they emphasize the importance of integrated join work within the value creation element. Overall, all participants are interested in reducing costs, they expect initiatives from each other in offering sustainable and innovative solutions, and to achieve these, innovative cooperation is needed.
AcknowledgmentThe study is supported by a grant from the Research Based Innovation “SFI Marine Operation in Virtual Environment (SFI-MOVE)” (Project no: 237929) in Norway.