bluuebunny/crossref_metadata_2025 huggingface dataset:
Deep-Learning-Based Detection of Paroxysmal Supraventricular Tachycardia Using Sinus-Rhythm Electrocardiograms
Authors: Wang Lei , Dang Shipeng , Chen Shuangxiong , Sun Jin-Yu , Wang Ru-Xing , Pan Feng
Published: August 2022

Background: Paroxysmal supraventricular tachycardia (PSVT) is a common arrhythmia associated with palpitation and a decline in quality of life. However, it is undetectable with sinus-rhythmic ECGs when patients are not in the symptomatic onset stage. Methods: In the current study, a convolution neural network (CNN) was trained with normal-sinus-rhythm standard 12-lead electrocardiographs (ECGs) of negative control patients and PSVT patients to identify patients with unrecognized PSVT. PSVT refers to atrioventricular nodal reentry tachycardia or atrioventricular reentry tachycardia based on a concealed accessory pathway as confirmed by electrophysiological procedure. Negative control group data were obtained from 5107 patients with at least one normal sinus-rhythmic ECG without any palpitation symptoms. All ECGs were randomly allocated to the training, validation and testing datasets in a 7:1:2 ratio. Model performance was evaluated on the testing dataset through F1 score, overall accuracy, area under the curve, sensitivity, specificity and precision. Results: We retrospectively enrolled 407 sinus-rhythm ECGs of PSVT procedural patients and 1794 ECGs of control patients. A total of 2201 ECGs were randomly divided into training (n = 1541), validation (n = 220) and testing (n = 440) datasets. In the testing dataset, the CNN algorithm showed an overall accuracy of 95.5%, sensitivity of 90.2%, specificity of 96.6% and precision of 86.0%. Conclusion: Our study reveals that a well-trained CNN algorithm may be a rapid, effective, inexpensive and reliable method to contribute to the detection of PSVT.
MTHFR Polymorphism and Folic Acid Supplementation Influence Serum Homocysteine Levels in Psoriatic Patients Treated with Methotrexate
Authors: Zhang Qi , Lin Jinran , Zhang Zhenghua , Han Ling , Huang Qiong , Zhu Jie , Wang Bing , Fang Xu , Zheng Zhizhong , Yawalkar Nikhil , Liang Jun , Yan Kexiang
Published: August 2022

Background: Hyperhomocysteinemia has been reported in psoriasis. We investigated the effect of methylenetetrahydrofolate reductase (MTHFR), polymorphism and folic acid supplementation on serum homocysteine levels in psoriasis. Methods: Serum homocysteine levels were detected at baseline and at week 12 in 201 patients who were genotyped with MTHFR rs1801133 without and 93 psoriatic patients with folate supplement. Results: TT genotype carriers of MTHFR rs1801133 had significantly higher serum homocysteine levels at baseline and at week 12, a better PASI 75 response rate at week 8, and a higher PASI 90 response rate at week 12 than the CT and CC genotype carriers. Multiple regression analysis demonstrated that serum homocysteine concentration at baseline was significantly associated with sex, weight, PASI score at baseline, and the rs1801133 genotype. The significant upregulation of serum homocysteine levels after treatment with methotrexate (MTX) was only observed in male CT and CC genotype carriers and female CC genotype carriers. In contrast, folic acid supplementation significantly decreased serum homocysteine levels after MTX treatment but only in male psoriatic patients. Conclusions: The effect of MTX on serum homocysteine levels was associated with the polymorphism of MTHFR rs1801133 and sex. Folic acid supplementation only decreased serum homocysteine levels in male psoriatic patients.
Comprehensive Management of Inflammatory Bowel Disease: What’s Next
Authors: Levartovsky Asaf , Kopylov Uri
Published: August 2022

In the last 20 years, the treatment and management of patients with Crohn’s disease (CD) and ulcerative colitis (UC) have been revolutionized by the introduction of biological therapies and small molecules [...]
Comparison of the Effects of Esketamine/Propofol and Sufentanil/Propofol on the Incidence of Intraoperative Hypoxemia during Bronchoscopy: Protocol for a Randomized, Prospective, Parallel-Group Trial
Authors: Huang Xiao , Ai Pan , Wei Changwei , Sun Yuan , Wu Anshi
Published: August 2022

Background: Propofol, ketamine, and sufentanil are the most commonly used anesthetics during bronchoscopy, alone or in combination, for sedation. Esketamine is an s-enantiomer of ketamine racemate and has both sedative and analgesic effects. Esketamine does not inhibit respiration and maintains hemodynamic stability. This study aims to compare the clinical efficacy of esketamine/propofol with sufentanil/propofol for patients during bronchoscopy. Methods: Patients undergoing bronchoscopy will be randomly assigned to receive either sufentanil/propofol (sufentanil group; n = 33; sufentanil: 0.2 μg/kg) or esketamine/propofol (esketamine group; n = 33; esketamine: 0.2 mg/kg) for sedation and analgesia. Intraoperative clinical information, general anesthetic drug dosage, the incidence of intraoperative hypoxemia, total time of hypoxemia, awakening time, delirium, nausea and vomiting, adverse reactions, and patient satisfaction will be collected. Discussion: Hypoxia has detrimental effects on patients with respiratory disease. Ameliorating hypoxemia in patients undergoing bronchoscopy is critical. Our results will provide effective sedation with esketamine in patients undergoing bronchoscopy. Trial registration: Chinese clinical trial registry: ChiCTR2200058990.
Is Fetal Hydrops in Turner Syndrome a Risk Factor for the Development of Maternal Mirror Syndrome?
Authors: Bedei Ivonne Alexandra , Graf Alexander , Gloning Karl-Philipp , Meyer-Wittkopf Matthias , Willner Daria , Krapp Martin , Hentze Sabine , Scharf Alexander , Degenhardt Jan , Heling Kai-Sven , Kozlowski Peter , Trautmann Kathrin , Jahns Kai , Geipel Anne , Tekesin Ismail , Elsässer Michael , Wilhelm Lucas , Gottschalk Ingo , Baumüller Jan-Erik , Birdir Cahit , Zöllner Felix , Wolter Aline , Schenk Johanna , Gehrke Tascha , Keil Corinna , Espinosa Jimmy , Axt-Fliedner Roland
Published: August 2022

Mirror syndrome is a rare and serious maternal condition associated with immune and non-immune fetal hydrops after 16 weeks of gestational age. Subjacent conditions associated with fetal hydrops may carry different risks for Mirror syndrome. Fetuses with Turner syndrome are frequently found to be hydropic on ultrasound. We designed a retrospective multicenter study to evaluate the risk for Mirror syndrome among pregnancies complicated with Turner syndrome and fetal hydrops. Data were extracted from a questionnaire sent to specialists in maternal fetal medicine in Germany. Out of 758 cases, 138 fulfilled our inclusion criteria and were included in the analysis. Of the included 138, 66 presented with persisting hydrops at or after 16 weeks. The frequency of placental hydrops/placentomegaly was rather low (8.1%). Of note, no Mirror syndrome was observed in our study cohort. We propose that the risk of this pregnancy complication varies according to the subjacent cause of fetal hydrops. In Turner syndrome, the risk for Mirror syndrome is lower than that reported in the literature. Our observations are relevant for clinical management and parental counseling.
Associations between Demographics, Tinnitus Specific-, Audiological-, General- and Mental Health Factors, and the Impact of Tinnitus on Daily Life
Authors: Rademaker Maaike M. , Stegeman Inge , Brabers Anne E. M. , de Jong Judith D. , Stokroos Robert J. , Smit Adriana L.
Published: August 2022

Our objective was to study associations between demographics, tinnitus specific-, audiological-, general- and mental health characteristics, and impact of tinnitus in the general population. In this cross-sectional survey study in the Dutch population, data were prospectively gathered. Tinnitus impact was assessed with the Tinnitus Functional Index (TFI). We included participants who experienced tinnitus and for whom a total TFI score could be calculated (n = 212). We performed univariable and multivariable regression analyses. Due to logarithmical transformation, the B-scores were back-transformed to show the actual difference in points on the TFI. People who considered hyperacusis a small problem had a 12.5-point higher TFI score, those who considered it a mediocre problem had a 17.6-point higher TFI score and those who considered it a large problem had a 24.1-point higher TFI score compared to people who did not consider hyperacusis a problem. People who indicated having minor hearing problems had a 10.5-point higher TFI score, those with mediocre hearing problems had a 20.4-point higher TFI score and those with severe hearing problems had a 41.6-point higher TFI score compared to people who did not have subjective hearing problems. In conclusion, audiological risk factors, such as hearing problems and hyperacusis, have the largest association with the impact of tinnitus on daily life, compared to other assessed variables. The results of this study can be used in future research to find targeted interventions to diminish the impact of tinnitus.
Virtual Surgical Planning and Customized Subperiosteal Titanium Maxillary Implant (CSTMI) for Three Dimensional Reconstruction and Dental Implants of Maxillary Defects after Oncological Resection: Case Series
Authors: Cebrián Carretero Jose Luís , Del Castillo Pardo de Vera José Luis , Montesdeoca García Néstor , Garrido Martínez Pablo , Pampín Martínez Marta María , Aragón Niño Iñigo , Navarro Cuéllar Ignacio , Navarro Cuéllar Carlos
Published: August 2022

Maxillectomies cause malocclusion, masticatory disorders, swallowing disorders and poor nasolabial projection, with consequent esthetic and functional sequelae. Reconstruction can be achieved with conventional approaches, such as closure of the maxillary defect by microvascular free flap surgery or prosthetic obturation. Four patients with segmental maxillary defects that had been reconstructed with customized subperiosteal titanium maxillary implants (CSTMI) through virtual surgical planning (VSP), STL models and CAD/CAM titanium mesh were included. The smallest maxillary defect was 4.1 cm and the largest defect was 9.6 cm, with an average of 7.1 cm. The reconstructed maxillary vertical dimension ranged from 9.3 mm to 17.4 mm, with a mean of 13.17 mm. The transverse dimension of the maxilla at the crestal level was attempted to be reconstructed based on the pre-excision CT scan, and these measurements ranged from 6.5 mm in the premaxilla area to 14.6 mm at the posterior level. All patients were rehabilitated with a fixed prosthesis on subperiosteal implants with good esthetic and functional results. In conclusion, we believe that customized subperiosteal titanium maxillary implants (CSTMI) are a safe alternative for maxillary defects reconstruction, allowing for simultaneous dental rehabilitation while restoring midface projection. Nonetheless, prospective and randomized trials are required with long-term follow-up, to assess its long-term performance and safety.
Large Amplitude Iris Fluttering Detected by Consecutive Anterior Segment Optical Coherence Tomography Images in Eyes with Intrascleral Fixation of an Intraocular Lens
Authors: Inoue Makoto , Koto Takashi , Hirakata Akito
Published: August 2022

Saccadic eye movements induce movements of the aqueous and vitreous humor and iris fluttering. To evaluate iris fluttering during eye movements, anterior segment optical coherence tomography (AS-OCT) was used in 29 eyes with pars plana vitrectomy (PPV) and intrascleral fixation of an intraocular lens (ISF group) and 15 eyes with PPV and an IOL implantation into lens capsular bag (control group). The height of the iris from the iris plane (the line between the anterior chamber angles) was compared every 0.2 s after the eye had moved from a temporal to the primary position (time 0). The height of the nasal iris in the ISF group decreased to −0.68 ± 0.43 mm at 0 s (p < 0.001) and returned to −0.06 ± 0.23 mm at 0.2 s. The height of the temporal iris increased to 0.45 ± 0.31 mm at 0 s (p < 0.001) and returned to −0.06 ± 0.18 mm at 0.2 s. The height of the nasal iris at 0 s in the ISF group was significantly lower, and that of the temporal iris was significantly higher than the control (−0.05 ± 0.09 mm, 0.03 ± 0.06 mm, p < 0.001, respectively). Iris fluttering can act as a check valve for aqueous and vitreous humor movements and can be quantified by consecutive AS-OCT images. Large amplitude iris fluttering in eyes with intrascleral fixation is important because it can lead to a reverse pupillary block.
Technological Advances in the Diagnosis and Management of Tinnitus
Authors: Lopez-Escamez Jose Antonio , Perez-Carpena Patricia
Published: August 2022

Tinnitus disorder is a bothersome perception of a composite noise or tone in the ears in the absence of an external source, associated with emotional distress, cognitive dysfunction, and/or autonomic arousal [...]
Survival Rates and Factors Affecting the Outcome Following Immediate and Delayed Implant Placement: A Retrospective Study
Authors: Chatzopoulos Georgios S. , Wolff Larry F.
Published: August 2022

Background: Immediate implant placement into extraction sockets has become a widely acceptable treatment option to decrease treatment time and enhance esthetics. The objectives of this study were to assess and compare the survival rates of immediate and delayed implant treatment as well as to investigate the effect of patient- and site-related variables on the treatment outcome in a large-scale population-based study. Methods: Dental records of patients who received implant therapy were retrieved from the electronic records of the University of Minnesota School of Dentistry. Demographic characteristics, dental insurance status, socioeconomic status as well as medical history and tobacco use were recorded. The treatment outcome was included as a binary variable (survival/failure). Time to failure (date of procedure to date of visit with failure) was compared between immediate and delayed implant treatment in Cox regression models. Kaplan–Meier plots for the survival of both treatment modalities were created. Patient-sites without failure were censored at the last follow-up visit. Results: A total of 4519 records of implants were included. The sample mean age was 60.27 years and included 50.7% males and 12.9% tobacco users. High socioeconomic status was characterized for 82.3% of the included population and 63.0% of them were self-payers. Immediate implants were significantly more frequently placed in the maxillary arch (p < 0.001) than in the mandible. Tobacco users received more often a delayed rather than an immediate implant placement (p = 0.001). The survival rate analysis revealed there were no significant differences between immediate and delayed implant placements (p = 0.48). The mean follow-up time was 32.27 months during which 1.5% immediate and 1.1% delayed implants were removed. The estimated mean survival time for immediate implants was 68.90 months, while delayed implants placed in healed sockets showed a mean survival time of 75.11 months. A statistically significant association was found between gender (p = 0.03) and osteoporosis (p = 0.001) with treatment outcome. Conclusions: The placement of immediate implants achieved similarly high survival rates when compared to delayed implants placed in healed sites. Males and osteoporotic individuals showed significantly higher implant failure than females and non-osteoporotic patients. This study demonstrated that both immediate and delayed implant placements are sound options with predictable treatment outcome.
I-FABP as a Potential Marker for Intestinal Barrier Loss in Porcine Polytrauma
Authors: Vollrath Jan Tilmann , Klingebiel Felix , Bläsius Felix , Greven Johannes , Bolierakis Eftychios , Nowak Aleksander J. , Simic Marija , Hildebrand Frank , Marzi Ingo , Relja Borna
Published: August 2022

Polytrauma and concomitant hemorrhagic shock can lead to intestinal damage and subsequent multiple organ dysfunction syndrome. The intestinal fatty acid-binding protein (I-FABP) is expressed in the intestine and appears quickly in the circulation after intestinal epithelial cell damage. This porcine animal study investigates the I-FABP dynamics in plasma and urine after polytrauma. Furthermore, it evaluates to what extent I-FABP can also act as a marker of intestinal damage in a porcine polytrauma model. Eight pigs (Sus scrofa) were subjected to polytrauma which consisted of lung contusion, tibial fracture, liver laceration, and hemorrhagic shock followed by blood and fluid resuscitation and fracture fixation with an external fixator. Eight sham animals were identically instrumented but not injured. Afterwards, intensive care treatment including mechanical ventilation for 72 h followed. I-FABP levels in blood and urine were determined by ELISA. In addition, immunohistological staining for I-FABP, active caspase-3 and myeloperoxidase were performed after 72 h. Plasma and urine I-FABP levels were significantly increased shortly after trauma. I-FABP expression in intestinal tissue showed significantly lower expression in polytraumatized animals vs. sham. Caspase-3 and myeloperoxidase expression in the immunohistological examination were significantly higher in the jejunum and ileum of polytraumatized animals compared to sham animals. This study confirms a loss of intestinal barrier after polytrauma which is indicated by increased I-FABP levels in plasma and urine as well as decreased I-FABP levels in immunohistological staining of the intestine.
Increased Apoptotic Activity in Low-Risk Myelodysplastic Syndrome
Authors: Park Songyi , Shin Dong-Yeop , Park Junseo Steve , Park Hee Sue , Moon Soo Young , Yoon Sung-Soo , Lee Dong-Soon
Published: August 2022

Myelodysplastic syndrome (MDS) is a heterogeneous hematopoietic disorder associated with cellular proliferative and apoptotic activity. We retrospectively investigated these activities in bone marrow samples from 76 MDS patients using immunohistochemical staining for Ki-67 and cleaved caspase-3. We divided cleaved caspase-3 into two groups based on median value and compared the differences according to MDS risk scoring systems. We compared MDS patient indices with idiopathic cytopenia of undetermined significance (ICUS) and healthy control (HC) indices using our previously published data. Cleaved caspase-3 immunohistochemistry was highest in MDS patients, followed by ICUS patients and HCs. Similarly, the mean Ki-67 grade was also highest in MDS patients, followed by ICUS patients and HCs. Higher cleaved caspase-3 grade was significantly associated with lower IPSS-R score (p = 0.020), whereas Ki-67 was not associated with MDS. Interestingly, TET2 mutation was associated with decreased cleaved caspase-3 levels (p = 0.03). However, there was no significant association between proliferative/apoptotic activity and survival. Our results suggest that apoptotic activity gradually increases from healthy controls and ICUS patients to MDS patients. Furthermore, higher apoptotic activity was associated with better MDS patient prognostic scores. Further studies are needed to reveal the differences in apoptotic activity between lower- and higher-risk MDS.
Composite Overwrapped Pressure Vessel Design Optimization Using Numerical Method
Authors: Regassa Yohannes , Gari Jema , Lemu Hirpa G.
Published: August 2022

Composite Overwrapped Pressure Vessels (COPVs) are widely used in fields including aeronautics and by companies such as SpaceX to hold high pressure fluids. They are favored for these applications because they are far lighter than all-metal vessels, although they demand special design, manufacturing, and testing requirements. In this study, finite element modeling was used to conducted stress and damage assessments on a composite overwrapped pressure vessel that has a 4 mm thick aluminum core cylinder. To develop the optimum COPV, the lamina sequences, thickness, and fiber winding angle were considered. The relationship between these variables and the composite-overwrapped structure’s maximum burst pressure bearing capacity was assessed. The ABAQUS composite modeler was used to design and generate 14 models of COPVs from carbon fiber/epoxy plies with a consistent thickness of 6.5 mm and various fiber angle orientations. The effects of the ply stacking order were analyzed by the finite element analysis approach for all designed models, which had 13 layers of uniform thickness but a varying fiber orientation. A ply stacking sequence of [55°, −55°] PP winding pattern had an optimum COPV design profile, with a burst pressure bearing capacity of 24 MPa. The stress–strain distribution along the geometry of the COPV was also obtained using the finite element method, and it was found that the distribution is uniform over the surface of the COPV and that its peak values are found towards the polar boss section of the COPV. Extreme stress gradients were noticed when the boss nears its geometrical transition to the dome phase. This factor is evident from the change in the ply thickness caused by the overlapped fiber orientation. The results obtained from this study are useful for the design and application of composite overwrapped pressure vessels.
Development and Characterization of Aloe vera Mucilaginous-Based Hydrogels for Psoriasis Treatment
Authors: Jales Silvana T. L. , Barbosa Raquel de M. , de Albuquerque André C. , Duarte Luan H. V. , da Silva Girliane R. , Meirelles Lyghia M. A. , da Silva Tania M. S. , Alves Adriano F. , Viseras César , Raffin Fernanda N. , Moura Tulio F. A. de L.
Published: August 2022

The Aloe vera (L.) Burman f. pulp extract (AE), obtained from the inner parts of Aloe vera leaves, is rich in polysaccharides, including glucomannans, acemannans, pectic compounds, cellulose, and hemicelluloses; acemannan and glucomannan are considered the two main components responsible for most of the plant’s therapeutical properties. Besides having anti-inflammatory activity, these polysaccharides accelerate wound healing and promote skin regeneration, thus they can be utilized in healing products. The objective of this study was to develop Aloe vera mucilaginous-based hydrogels for topical use in psoriasis treatment. The hydrogels were prepared with 80% w/w of A. vera mucilaginous gel, evaluating two distinct polymers as the gelling agent: 1% carbopol 940 (FC1 and FC2) or 2% hydroxyethylcellulose (FH3 and FH4). FC1, FC2, FH3 and FH4 were evaluated for their organoleptic characteristics, rheological properties, pH and glucomannan content. Polysaccharide fractions (PFs) were extracted from the AE and used as a group of chemical markers and characterized by infrared (IR) spectroscopy and 1H nuclear magnetic resonance (1H NMR). The quantification of these markers in the raw material (AE) and in the hydrogels was carried out using spectrophotometric techniques in the UV-VIS region. The hydrogels-based hydroxyethylcellulose (FH3 and FH4) had glucomannan contents of 6.76 and 4.01 mg/g, respectively. Formulations with carbopol, FC1 and FC2, had glucomannan contents of 8.69 and 9.17 mg/g, respectively, an ideal pH for application on psoriasis, in addition to good spreadability and pseudoplastic and thixotropic behavior. Considering these results, hydrogel FC1 was evaluated for its keratolytic activity in a murine model of hyperkeratinization. For that, 0.5 mL of test formulations FC1 and FPC (0.05% clobetasol propionate cream) were topically applied to the proximal region of adult rats daily for 13 days. After euthanasia, approximately 2.5 cm of the proximal portion of each animal’s tail was cut and placed in 10% buffered formalin. Then, each tail fragment was processed and stained with hematoxylin and eosin (HE), and the results obtained from the histological sections indicated a 61% reduction in stratum corneum for animals treated with the A. vera hydrogel (FC1G) and 66% for animals treated with clobetasol propionate (PCG), compared to the group of animals that did not receive treatment (WTG). This study led to the conclusion that compared to the classic treatment (clobetasol propionate), the 80% A. vera hydrogel showed no significant difference, being effective in controlling hyperkeratinization.
Thermal Behaviour of Rebars and Steel Deck Components of Composite Slabs under Natural Fire
Authors: Filho Marcílio M. A. , Piloto Paulo A. G. , Balsa Carlos
Published: August 2022

Most of the studies involving composite slabs under fire follow the standard fire scenario described by the ISO 834 curve, disregarding the cooling-phase. However, recent studies show that this phase is equally important, as it can lead to the collapse of the structure. Therefore, the present research carried out a parametric study, using numerical models, validated through experimental tests, to evaluate the thermal behaviour of the composite slabs components under natural fire. The results showed that the maximum temperatures in the reinforcement bars occur during the cooling-phase, reaching temperatures up to 300% higher than at the heating-phase, on the steel deck occur at the end of heating, and that the concrete thickness above the steel deck influences the temperature of these components. Also, during the cooling-phase, a “heat bubble” effect is observed on the ribs of the composite slabs, where the reinforcement bars are normally placed. These results highlight the importance of considering different natural fire scenarios, in the structural performance and safety of composite slabs, since during the cooling-phase there is still heat transfer between the elements, which can lead to slab failure. New parameters are proposed to find the temperature of each component for different fire ratings.
Physico-Chemical Characterization of Alkali-Treated Ethiopian Arabica Coffee Husk Fiber for Composite Materials Production
Authors: Amena Berhanu Tolessa , Altenbach Holm , Tibba Getechew Shunki , Hossain Nazia
Published: August 2022

Chemical treatment is a significant factor in improving the natural fiber quality for composite materials production. In this study, the alkaline treatment of Ethiopian Arabica coffee husk by sodium hydroxide (NaOH) was performed to improve the fiber quality. A total of 10% (w/w) NaOH has been applied for the alkaline treatment. Comprehensive physicochemical characterizations, such as proximate analysis, cellulosic composition, porosity, and structural analysis of treated and untreated coffee husk, have been conducted and compared. The experimental results showed that lignin and hemicellulose were reduced by 72% and 52%, respectively, thus improving the overall fiber quality. Therefore, this study indicated alkaline treatment of Ethiopian coffee husk is effective for fiber quality enhancement. It can be applied as a potential feedstock for fiber production in the composite production sector.
A Dataset for Temporal Semantic Segmentation Dedicated to Smart Mobility of Wheelchairs on Sidewalks
Authors: Decoux Benoit , Khemmar Redouane , Ragot Nicolas , Venon Arthur , Grassi-Pampuch Marcos , Mauri Antoine , Lecrosnier Louis , Pradeep Vishnu
Published: August 2022

In smart mobility, the semantic segmentation of images is an important task for a good understanding of the environment. In recent years, many studies have been made on this subject, in the field of Autonomous Vehicles on roads. Some image datasets are available for learning semantic segmentation models, leading to very good performance. However, for other types of autonomous mobile systems like Electric Wheelchairs (EW) on sidewalks, there is no specific dataset. Our contribution presented in this article is twofold: (1) the proposal of a new dataset of short sequences of exterior images of street scenes taken from viewpoints located on sidewalks, in a 3D virtual environment (CARLA); (2) a convolutional neural network (CNN) adapted for temporal processing and including additional techniques to improve its accuracy. Our dataset includes a smaller subset, made of image pairs taken from the same places in the maps of the virtual environment, but from different viewpoints: one located on the road and the other located on the sidewalk. This additional set is aimed at showing the importance of the viewpoint in the result of semantic segmentation.
Review on Fixed and Floating Offshore Structures. Part I: Types of Platforms with Some Applications
Authors: Amaechi Chiemela Victor , Reda Ahmed , Butler Harrison Obed , Ja’e Idris Ahmed , An Chen
Published: August 2022

Diverse forms of offshore oil and gas structures are utilized for a wide range of purposes and in varying water depths. They are designed for unique environments and water depths around the world. The applications of these offshore structures require different activities for proper equipment selection, design of platform types, and drilling/production methods. This paper will provide a general overview of these operations as well as the platform classifications. In this paper, a comprehensive review is conducted on different offshore petroleum structures. This study examines the fundamentals of all types of offshore structures (fixed and floating), as well as the applications of these concepts for oil exploration and production. The study also presents various design parameters for state-of-the-art offshore platforms and achievements made in the industry. Finally, suitable types of offshore platforms for various water depths are offered for long-term operations. An extension of this study (Part II) covers sustainable design approaches and project management on these structures; this review helps designers in understanding existing offshore structures, and their uniqueness. Hence, the review also serves as a reference data source for designing new offshore platforms and related structures.
The Contribution of the Vendée Globe Race to Improved Ocean Surface Information: A Validation of the Remotely Sensed Salinity in the Sub-Antarctic Zone
Authors: Umbert Marta , Hoareau Nina , Salat Jordi , Salvador Joaquín , Guimbard Sébastien , Olmedo Estrella , Gabarró Carolina
Published: August 2022

The Vendée Globe is the world’s most famous solo, non-stop, unassisted sailing race. The Institute of Marine Sciences and the Barcelona Ocean Sailing Foundation installed a MicroCAT on the One Ocean One Planet boat. The skipper, Dídac Costa, completed the round trip in 97 days, from 8 November 2020 to 13 February 2021, providing one measurement of temperature and conductivity every 30 s during navigation. More than half of the ship’s route was in the sub-Antarctic zone, between the tropical and polar fronts, and it passed through areas of oceanographic interest such as Southern Patagonia (affected by glacier melting), the Brazil–Malvinas confluence, the Southern Pacific Ocean, and the entire Southern Indian Ocean. This sailing race gave a rare opportunity to measure in-situ sea surface salinity in a region where satellite salinity measurements are not reliable. Due to the decreased sensitivity of brightness temperature to salinity in cold seas, retrieving sea surface salinity at high latitudes remains a major challenge. This paper describes how the data are processed and uses the data to validate satellite salinity products in the sub-Antarctic zone. The sailing race measurements represent surface information (60 cm depth) not available from drifters or Argo floats. Acquiring measurements using round-the-world sailing races would allow us to analyse the evolution of ocean salinity and the impact of changes in the ice extent around Antarctica.
Wave Energy Resource Assessment for Small-Scale WEC near a Harbour
Authors: Guillou Nicolas , Chapalain Georges , Sergent Philippe
Published: August 2022

Accurate evaluations of the available and technically exploitable wave energy resources are fundamental to optimise the design and implementation of energy converters in the marine environment. However, long-term resource assessments have been primarily conducted for large-scale devices in offshore energetic locations, thus ignoring onshore sites such as harbours with easier access, installation and accessibility to devices. Here, we conducted a ten-year evaluation of the performance of wave energy converters (WECs) off Roscoff harbour (northern Brittany, France). As the site of application shows moderately energetic conditions, particular attention was dedicated to small-scale WECs by adapting ratings to the local wave climate. This investigation combined (i) a high-spatial resolution (~5 m) hindcast database established with SWAN with (ii) generic and specific assessments of WEC performance. We exploited, in particular, scaled power matrices derived from the Oyster technology to assess the capacity factors and energy output of devices. In addition to characterising the annual and seasonal variability of the available resource off the harbour breakwater, this investigation provided further insights for optimising WECs, including experimental prototypes. It is therefore suggested that this type of evaluation be considered for the assessment of small- and/or full-scale energy converters in the marine environment.
An In Vitro Approach for Investigating the Safety of Lipotransfer after Breast-Conserving Therapy
Authors: Promny Theresa , Kutz Chiara-Sophia , Jost Tina , Distel Luitpold V. , Kadam Sheetal , Schmid Rafael , Arkudas Andreas , Horch Raymund E. , Kengelbach-Weigand Annika
Published: August 2022

The application of lipotransfer after breast-conserving therapy (BCT) and irradiation in breast cancer patients is an already widespread procedure for reconstructing volume deficits of the diseased breast. Nevertheless, the safety of lipotransfer has still not been clarified yet due to contradictory data. The goal of this in vitro study was to further elucidate the potential effects of lipotransfer on the irradiated remaining breast tissue. The mammary epithelial cell line MCF-10A was co-cultured with the fibroblast cell line MRC-5 and irradiated with 2 and 5 Gy. Afterwards, cells were treated with conditioned medium (CM) from adipose-derived stem cells (ADSC), and the effects on the cellular functions of MCF-10A cells and on gene expression at the mRNA level in MCF-10A and MRC-5 cells were analyzed. Treatment with ADSC CM stimulated transmigration and invasion and decreased the surviving fraction of MCF-10A cells. Further, the expression of cytokines, extracellular, and mesenchymal markers was enhanced in mammary epithelial cells. Only an effect of ADSC CM on irradiated fibroblasts could be observed. The present data suggest epithelial–mesenchymal transition-like changes in the epithelial mammary breast cell line. Thus, the benefits of lipotransfer after BCT should be critically weighed against its possible risks for the affected patients.
Development and Characterization of an Ex Vivo Testing Platform for Evaluating Automated Central Vascular Access Device Performance
Authors: Boice Emily N. , Berard David , Hernandez Torres Sofia I. , Avital Guy , Snider Eric J.
Published: August 2022

Access to the central vasculature is critical for hemodynamic monitoring and for delivery of life-saving therapeutics during emergency medicine and battlefield trauma situations but requires skill often unavailable in austere environments. Automated central vascular access devices (ACVADs) using ultrasound and robotics are being developed. Here, we present an ex vivo lower-body porcine model as a testing platform for evaluation of vascular devices and compare its features to commercially available platforms. While the commercially available trainers were simpler to set-up and use, the scope of their utility was limited as they were unable to provide realistic anatomic, physiologic, and sonographic properties that were provided by the ex vivo model. However, the ex vivo model was more cumbersome to set-up and use. Overall, both have a place in the development and evaluation pipeline for ACVADs before testing on live animals, thus accelerating product development and translation.
Proposal for a Paradigm Shift in Personalized Medicine for Patients with a Maxillary Edentulous Jaw by ENT Specialist and Dentist Cooperation
Authors: Baba Yuh , Kato Yasumasa , Takahashi Keiso
Published: August 2022

With the spread of oral implant therapy, serious medical complications related to implant surgery are becoming a social problem. Although the number of complications after implant surgery in the edentulous jaw is decreasing in Japan, maxillary-sinus-related complications (MSRCs) have reached the highest number since 2012. It is essential to identify and eliminate possible predisposing risk factors for MSRCs at an early stage to prevent MSRCs. In this review article, we highlight the causal factors of postoperative complications with or without sinus augmentation for the maxillary molar region to achieve optimal treatment outcomes and reduce complications. In particular, we focus on anatomical variations that can cause the impairment of maxillary sinus drainage. Furthermore, we emphasize that the paradigm for personalized medicine for patients with a maxillary edentulous jaw by ENT specialist and dentist cooperation is shifting from the traditional assessment of maxillary sinus pathologies alone to the new assessment of anatomic variations that can cause the impairment of maxillary sinus drainage in addition to maxillary sinus pathologies.
Global Challenges to Public Health Care Systems during the COVID-19 Pandemic: A Review of Pandemic Measures and Problems
Authors: Filip Roxana , Gheorghita Puscaselu Roxana , Anchidin-Norocel Liliana , Dimian Mihai , Savage Wesley K.
Published: August 2022

Beginning in December 2019, the world faced a critical new public health stressor with the emergence of SARS-CoV-2. Its spread was extraordinarily rapid, and in a matter of weeks countries across the world were affected, notably in their ability to manage health care needs. While many sectors of public structures were impacted by the pandemic, it particularly highlighted shortcomings in medical care infrastructures around the world that underscored the need to reorganize medical systems, as they were vastly unprepared and ill-equipped to manage a pandemic and simultaneously provide general and specialized medical care. This paper presents modalities in approaches to the pandemic by various countries, and the triaged reorganization of medical sections not considered first-line in the pandemic that was in many cases transformed into wards for treating COVID-19 cases. As new viruses and structural variants emerge, it is important to find solutions to streamline medical care in hospitals, which includes the expansion of digital network medicine (i.e., telemedicine and mobile health apps) for patients to continue to receive appropriate care without risking exposure to contagions. Mobile health app development continues to evolve with specialized diagnostics capabilities via external attachments that can provide rapid information sharing between patients and care providers while eliminating the need for office visits. Telemedicine, still in the early stages of adoption, especially in the developing world, can ensure access to medical information and contact with care providers, with the potential to release emergency rooms from excessive cases, and offer multidisciplinary access for patients and care providers that can also be a means to avoid contact during a pandemic. As this pandemic illustrated, an overhaul to streamline health care is essential, and a move towards greater use of mobile health and telemedicine will greatly benefit public health to control the spread of new variants and future outbreaks.
Pepsin and the Lung—Exploring the Relationship between Micro-Aspiration and Respiratory Manifestations of Gastroesophageal Reflux Disease
Authors: Iov Diana-Elena , Bărboi Oana-Bogdana , Floria Mariana , Neamțu Andrei , Iliescu Radu , Drug Vasile-Liviu
Published: August 2022

Gastroesophageal reflux disease (GERD) is one of the most commonly encountered disorders in clinical practice nowadays, with an increasing burden on healthcare systems worldwide. GERD-related respiratory symptoms such as unexplained chronic cough, bronchial asthma or chronic obstructive pulmonary disease (COPD) with frequent exacerbations often pose diagnostic and therapeutic challenges and may require a multidisciplinary approach. Moreover, a potential role of GERD as a risk factor has been proposed for chronic rejection in patients who underwent lung transplantation. Pepsin has gained considerable attention from the scientific community in the last few years as a possible surrogate biomarker for GERD. The aim of this narrative review was to provide an overview of the potential utility of pepsin detection as a marker of micro-aspiration in various biological fluids retrieved from patients with suspected GERD-induced respiratory manifestations and in lung transplant patients with allograft dysfunction. Data on the subject remains highly contradictory, and while certain studies support its applicability in investigating atypical GERD manifestations, at the moment, it would be realistic to accept a modest utility at best. A major lack of consensus persists regarding topics such as the optimal timeframe for fluid collection and cut-off values. Further research is warranted in order to address these issues.
Machine-Learning-Based Indoor Mobile Positioning Using Wireless Access Points with Dual SSIDs—An Experimental Study
Authors: Paudel Krishna , Kadel Rajan , Guruge Deepani B.
Published: August 2022

Location prediction in an indoor environment is a challenge, and this has been a research trend for recent years, with many potential applications. In this paper, machine-learning-based regression algorithms and Received Signal Strength Indicator (RSSI) fingerprint data from Wireless Access Points (WAPs) with dual Service set IDentifiers (SSIDs) are used, and positioning prediction and location accuracy are compared with single SSIDs. It is found that using Wi-Fi RSSI data from dual-frequency SSIDs improves the location prediction accuracy by up to 19%. It is also found that Support Vector Regression (SVR) gives the best prediction among classical machine-learning algorithms, followed by K-Nearest Neighbour (KNN) and Linear Regression (LR). Moreover, we analyse the effect of fingerprint grid size, coverage of the Reference Points (RPs) and location of the Test Points (TPs) on the positioning prediction and location accuracy using these three best algorithms. It is found that the prediction accuracy depends upon the fingerprint grid size and the boundary of the RPs. Experimental results demonstrates that reducing fingerprint grid size improves the positioning prediction and location accuracy. Further, the result also shows that when all the TPs are inside the boundary of RPs, the prediction accuracy increases.
Influence of Flight Height and Image Sensor on the Quality of the UAS Orthophotos for Cadastral Survey Purposes
Authors: Sertić Hrvoje , Paar Rinaldo , Tomić Hrvoje , Ravlić Fabijan
Published: August 2022

The possibility of using unmanned aircraft systems (UAS) for cadastral survey purposes was investigated in this research. A study site consisting of 26 ground control points (GCP) and checkpoints (CP) was established. The study site was first measured by the classical methods of geodetic surveying, i.e., by the polar method using a total station. After that, all points were additionally measured by the Global Navigation Satellite System (GNSS) Real-Time Kinematic (RTK) method. The GNSS RTK method was used to determine the coordinates of all points in the official map projection of Croatia, HTRS96/TM, while the polar method was used to increase the positional “strength” of points in all directions, i.e., to improve the relative accuracy between them. Using UASs with different image sensor characteristics, the study site was measured by an aerial photogrammetry method at different flight heights with the purpose of obtaining a high-quality digital orthophoto plan (DOF). The absolute orientation of the model was performed using the external orientation data of each digital image based on GNSS and Inertial Measurement Unit (IMU) UAS’s sensors, as well as using GCPs. Achieved precision of obtained DOF, as well as accuracy analysis of aerial photogrammetry was performed by considering the adjusted survey data collected by classical and GNSS RTK methods as true values and comparing them with the coordinates obtained by the aerial photogrammetry method from DOFs. Based on the achieved results and conclusions obtained from the study site, the second field test was performed above a small settlement which served as an area for cadastral survey using the UAS and GNSS RTK method. Again, precision and accuracy were determined, based on which we derived recommendations and conclusions for using UASs for cadastral survey purposes.
Spatial Pattern of Soil Erosion in Relation to Land Use Change in a Rolling Hilly Region of Northeast China
Authors: Zhu Yuanli , Li Wenbo , Wang Dongyan , Wu Zihao , Shang Peng
Published: August 2022

The black soil region in Northeast China is one of the major grain-producing areas of China. Soil erosion in the black soil region caused by natural factors and anthropic activities has attracted much attention, especially in a rolling hilly region. Compared with natural factors, the land use factor of cropland encompasses the most easily optimized measures. Jiutai County of Changchun City, located in the hilly areas of Northeast China, was taken as an example to calculate the soil erosion modulus using the Revised Universal Soil Loss Equation model. The overall soil erosion status of cultivated land in the study area was mainly slight and light, the proportion of cultivated land affected by extremely intensive and severe erosion was relatively small, and the average soil erosion modulus was 7.09 t·hm−2·a−1 in 2019. In view of spatial distribution characteristics of soil erosion revealed by the spatial aggregation and hot spot analysis, the most serious soil erosion intensity was concentrated in the southeast and northeast sloping farmland over 8°. With the increase in elevation and topographic slope, the proportion of slight and light soil erosion gradually decreased, which was closely related to the increase in soil erodibility caused by the space–time migration of soil organic carbon caused by the interaction of hydraulic and tillage erosion in complex topographic areas. The Geographically Weighted Regression model was introduced to explore the driving factors and superposition mechanism of farmland soil erosion in the hilly region of Northeast China. Based on the relationship between soil erosion and landscape fragmentation, landscape fragmentation was an important driving force promoting soil erosion, sediment yield, and sediment transport. This paper is committed to providing a basis for accurately deploying regional soil and water conservation measures and formulating macro land management policies.
Sustainable Forest, Beautiful Forest, Well-Managed Forest: Attitudes towards Land Management and Their Influence on the Perception of a Mediterranean Agroforestry Landscape
Authors: López-Rodríguez Alicia , Hernández-Jiménez Verónica
Published: August 2022

Aesthetic and ecological qualities overlap and interrelate in people’s attitudes towards landscapes. Additionally, the way a landscape manager is perceived, as well as the way a landscape is managed, usually play a significant role in the interpretation of these dimensions and how they are evaluated. A qualitative study was conducted in a Mediterranean agroforestry landscape (Sierra Oeste, Madrid) to understand how different components of a landscape (ecology, aesthetics, and management) influence the way that itis understood and valued by local stakeholders. Based on the results of a series of semistructured interviews and focus groups, a detailed analysis of the participants’ discourse was conducted. A series of guidelines for land planning and management were derived to reinforce the social perceptions of the landscape and enhance its ecological and aesthetic conditions.