bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 2 from Clinicopathologic, Genomic, and Immunophenotypic Landscape of ATM Mutations in Non–Small Cell Lung Cancer
Authors: Ricciuti Biagio , Elkrief Arielle , Alessi Joao , Wang Xinan , Li Yvonne , Gupta Hersh , Muldoon Daniel M. , Bertram Arrien A. , Pecci Federica , Lamberti Giuseppe , Di Federico Alessandro , Barrichello Adriana , Vaz Victor R. , Gandhi Malini , Lee Elinton , Shapiro Geoffrey I. , Park Hyesun , Nishino Mizuki , Lindsay James , Felt Kristen D. , Sharma Bijaya , Cherniack Andrew D. , Rodig Scott , Gomez Daniel R. , Shaverdian Narek , Rakaee Mehrdad , Bandlamudi Chaitanya , Ladanyi Marc , Janne Pasi A. , Schoenfeld Adam J. , Sholl Lynette M. , Awad Mark M. , Cheng Michael L.
Published: May 2023

Supplementary Figure 2. Proportion of samples with PD-L1 TPS ≥1%, ≥50%, ≥90% according to ATM mutation status (ATMMUT versus ATMWT).
Supplementary Figure 19 from Clinicopathologic, Genomic, and Immunophenotypic Landscape of ATM Mutations in Non–Small Cell Lung Cancer
Authors: Ricciuti Biagio , Elkrief Arielle , Alessi Joao , Wang Xinan , Li Yvonne , Gupta Hersh , Muldoon Daniel M. , Bertram Arrien A. , Pecci Federica , Lamberti Giuseppe , Di Federico Alessandro , Barrichello Adriana , Vaz Victor R. , Gandhi Malini , Lee Elinton , Shapiro Geoffrey I. , Park Hyesun , Nishino Mizuki , Lindsay James , Felt Kristen D. , Sharma Bijaya , Cherniack Andrew D. , Rodig Scott , Gomez Daniel R. , Shaverdian Narek , Rakaee Mehrdad , Bandlamudi Chaitanya , Ladanyi Marc , Janne Pasi A. , Schoenfeld Adam J. , Sholl Lynette M. , Awad Mark M. , Cheng Michael L.
Published: May 2023

Supplementary Figure 19. (A) Objective response rate, (B) progression-free survival, and (C) overall survival to PD-(L)1 immune checkpoint blockade monotherapy among patients with ATMMUT NSCLC, according to KEAP1 mutation. (D) Objective response rate, (E) progression-free survival, and (F) overall survival to PD-(L)1 immune checkpoint blockade in combination with platinum doublet chemotherapy among patients with ATMMUT NSCLC, according to KEAP1 mutation status
Supplementary Figure 18 from Clinicopathologic, Genomic, and Immunophenotypic Landscape of ATM Mutations in Non–Small Cell Lung Cancer
Authors: Ricciuti Biagio , Elkrief Arielle , Alessi Joao , Wang Xinan , Li Yvonne , Gupta Hersh , Muldoon Daniel M. , Bertram Arrien A. , Pecci Federica , Lamberti Giuseppe , Di Federico Alessandro , Barrichello Adriana , Vaz Victor R. , Gandhi Malini , Lee Elinton , Shapiro Geoffrey I. , Park Hyesun , Nishino Mizuki , Lindsay James , Felt Kristen D. , Sharma Bijaya , Cherniack Andrew D. , Rodig Scott , Gomez Daniel R. , Shaverdian Narek , Rakaee Mehrdad , Bandlamudi Chaitanya , Ladanyi Marc , Janne Pasi A. , Schoenfeld Adam J. , Sholl Lynette M. , Awad Mark M. , Cheng Michael L.
Published: May 2023

Supplementary Figure 18. (A) Objective response rate, (B) progression-free survival, and (C) overall survival to PD-(L)1 immune checkpoint blockade monotherapy among patients with ATMMUT NSCLC, according to STK11 mutation. (D) Objective response rate, (E) progression-free survival, and (F) overall survival to PD-(L)1 immune checkpoint blockade in combination with platinum doublet chemotherapy among patients with ATMMUT NSCLC, according to STK11 mutation.
Supplementary Figure 14 from Clinicopathologic, Genomic, and Immunophenotypic Landscape of ATM Mutations in Non–Small Cell Lung Cancer
Authors: Ricciuti Biagio , Elkrief Arielle , Alessi Joao , Wang Xinan , Li Yvonne , Gupta Hersh , Muldoon Daniel M. , Bertram Arrien A. , Pecci Federica , Lamberti Giuseppe , Di Federico Alessandro , Barrichello Adriana , Vaz Victor R. , Gandhi Malini , Lee Elinton , Shapiro Geoffrey I. , Park Hyesun , Nishino Mizuki , Lindsay James , Felt Kristen D. , Sharma Bijaya , Cherniack Andrew D. , Rodig Scott , Gomez Daniel R. , Shaverdian Narek , Rakaee Mehrdad , Bandlamudi Chaitanya , Ladanyi Marc , Janne Pasi A. , Schoenfeld Adam J. , Sholl Lynette M. , Awad Mark M. , Cheng Michael L.
Published: May 2023

Supplementary Figure 14. (A) Objective response rate, (B) progression-free survival, and (C) overall survival to PD-(L)1 immune checkpoint blockade monotherapy among patients with advanced/metastatic PD-L1 negative (<1%) NSCLC, according to ATM mutation status. (D) Objective response rate, (E) progression-free survival, and (F) overall survival to PD-(L)1 immune checkpoint blockade monotherapy among patients with advanced/metastatic PD-L1 intermediate (1-49%) NSCLC, according to ATM mutation status. (G) Objective response rate, (H) progression-free survival, and (I) overall survival to PD-(L)1 immune checkpoint blockade monotherapy among patients with advanced/metastatic PD-L1 high (≥50%) NSCLC, according to ATM mutation status.
Supplementary Figure 12 from Clinicopathologic, Genomic, and Immunophenotypic Landscape of ATM Mutations in Non–Small Cell Lung Cancer
Authors: Ricciuti Biagio , Elkrief Arielle , Alessi Joao , Wang Xinan , Li Yvonne , Gupta Hersh , Muldoon Daniel M. , Bertram Arrien A. , Pecci Federica , Lamberti Giuseppe , Di Federico Alessandro , Barrichello Adriana , Vaz Victor R. , Gandhi Malini , Lee Elinton , Shapiro Geoffrey I. , Park Hyesun , Nishino Mizuki , Lindsay James , Felt Kristen D. , Sharma Bijaya , Cherniack Andrew D. , Rodig Scott , Gomez Daniel R. , Shaverdian Narek , Rakaee Mehrdad , Bandlamudi Chaitanya , Ladanyi Marc , Janne Pasi A. , Schoenfeld Adam J. , Sholl Lynette M. , Awad Mark M. , Cheng Michael L.
Published: May 2023

Supplementary Figure 12. Disease-free survival and overall survival among patients with (A) stage I, (B) stage II, and (C) stage III NSCLC according to ATM expression by immunohistochemistry.
Supplementary Figure 11 from Clinicopathologic, Genomic, and Immunophenotypic Landscape of ATM Mutations in Non–Small Cell Lung Cancer
Authors: Ricciuti Biagio , Elkrief Arielle , Alessi Joao , Wang Xinan , Li Yvonne , Gupta Hersh , Muldoon Daniel M. , Bertram Arrien A. , Pecci Federica , Lamberti Giuseppe , Di Federico Alessandro , Barrichello Adriana , Vaz Victor R. , Gandhi Malini , Lee Elinton , Shapiro Geoffrey I. , Park Hyesun , Nishino Mizuki , Lindsay James , Felt Kristen D. , Sharma Bijaya , Cherniack Andrew D. , Rodig Scott , Gomez Daniel R. , Shaverdian Narek , Rakaee Mehrdad , Bandlamudi Chaitanya , Ladanyi Marc , Janne Pasi A. , Schoenfeld Adam J. , Sholl Lynette M. , Awad Mark M. , Cheng Michael L.
Published: May 2023

Supplementary Figure 11. Overall survival since the date of initial diagnosis among patients with stage IV NSCLC according to ATM mutation status.
Supplementary Figure 10 from Clinicopathologic, Genomic, and Immunophenotypic Landscape of ATM Mutations in Non–Small Cell Lung Cancer
Authors: Ricciuti Biagio , Elkrief Arielle , Alessi Joao , Wang Xinan , Li Yvonne , Gupta Hersh , Muldoon Daniel M. , Bertram Arrien A. , Pecci Federica , Lamberti Giuseppe , Di Federico Alessandro , Barrichello Adriana , Vaz Victor R. , Gandhi Malini , Lee Elinton , Shapiro Geoffrey I. , Park Hyesun , Nishino Mizuki , Lindsay James , Felt Kristen D. , Sharma Bijaya , Cherniack Andrew D. , Rodig Scott , Gomez Daniel R. , Shaverdian Narek , Rakaee Mehrdad , Bandlamudi Chaitanya , Ladanyi Marc , Janne Pasi A. , Schoenfeld Adam J. , Sholl Lynette M. , Awad Mark M. , Cheng Michael L.
Published: May 2023

Supplementary Figure 10. (A) Progression-free and (B) overall survival among all patients with stage III NSCLC according to ATM mutation status. (C) Progression-free and (D) overall survival among patients with stage III NSCLC who received concurrent chemoradiotherapy followed by durvalumab maintenance according to ATM mutation status.
Supplementary Figure 1. from Clinicopathologic, Genomic, and Immunophenotypic Landscape of ATM Mutations in Non–Small Cell Lung Cancer
Authors: Ricciuti Biagio , Elkrief Arielle , Alessi Joao , Wang Xinan , Li Yvonne , Gupta Hersh , Muldoon Daniel M. , Bertram Arrien A. , Pecci Federica , Lamberti Giuseppe , Di Federico Alessandro , Barrichello Adriana , Vaz Victor R. , Gandhi Malini , Lee Elinton , Shapiro Geoffrey I. , Park Hyesun , Nishino Mizuki , Lindsay James , Felt Kristen D. , Sharma Bijaya , Cherniack Andrew D. , Rodig Scott , Gomez Daniel R. , Shaverdian Narek , Rakaee Mehrdad , Bandlamudi Chaitanya , Ladanyi Marc , Janne Pasi A. , Schoenfeld Adam J. , Sholl Lynette M. , Awad Mark M. , Cheng Michael L.
Published: May 2023

Supplementary Figure 1. (A) ATM mutation classification schema (B) Lollipop plot of all 714 mutations in the ATM gene identified in the combined DFCI/MSK cohort. (C) Lollipop plot of all 152 benign mutations in the ATM gene identified in the combined DFCI/MSK cohort.
Data from Devimistat in Combination with Gemcitabine and Cisplatin in Biliary Tract Cancer: Preclinical Evaluation and Phase Ib Multicenter Clinical Trial (BilT-04)
Authors: Mohan Arathi , Griffith Kent A. , Wuchu Fulei , Zhen David B. , Kumar-Sinha Chandan , Crysler Oxana , Hsiehchen David , Enzler Thomas , Dippman Dominique , Gunchick Valerie , Achreja Abhinav , Animasahun Olamide , Choppara Srinadh , Nenwani Minal , Chinnaiyan Arul M. , Nagrath Deepak , Zalupski Mark M. , Sahai Vaibhav
Published: May 2023

AbstractPurpose:
Devimistat (CPI-613) is a novel inhibitor of tumoral mitochondrial metabolism. We investigated the effect of devimistat in vitro and in a phase Ib clinical trial in patients with advanced biliary tract cancer (BTC).
Patients and Methods:
Cell viability assays of devimistat ± gemcitabine and cisplatin (GC) were performed and the effect of devimistat on mitochondrial respiration via oxygen consumption rate (OCR) was evaluated. A phase Ib/II trial was initiated in patients with untreated advanced BTC. In phase Ib, devimistat was infused over 2 hours in combination with GC on days 1 and 8 every 21 days with a primary objective to determine the recommended phase II dose (RP2D). Secondary objectives included safety, overall response rate (ORR), progression-free survival (PFS), and overall survival (OS).
Results:
In vitro, devimistat with GC had a synergistic effect on two cell lines. Devimistat significantly decreased OCR at higher doses and in arms with divided dosing. In the phase Ib trial, 20 patients received a median of nine cycles (range, 3–19). One DLT was observed, and the RP2D of devimistat was determined to be 2,000 mg/m2 in combination with GC. Most common grade 3 toxicities included neutropenia (n = 11, 55%), anemia (n = 4, 20%), and infection (n = 3, 15%). There were no grade 4 toxicities. After a median follow-up of 15.6 months, ORR was 45% and median PFS was 10 months (95% confidence interval, 7.1–14.9). Median OS is not yet estimable.
Conclusion:
Devimistat in combination with GC is well tolerated and has an acceptable safety profile in patients with untreated advanced BTC.
Supplementary Data from RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors
Authors: Roulston Anne , Zimmermann Michal , Papp Robert , Skeldon Alexander , Pellerin Charles , Dumas-Bérube Émilie , Dumais Valerie , Dorich Stéphane , Fader Lee D. , Fournier Sara , Li Li , Leclaire Marie-Eve , Yin Shou Yun , Chefson Amandine , Alam Hunain , Yang William , Fugère-Desjardins Chloe , Vignini-Hammond Sabrina , Skorey Kathryn , Mulani Amina , Rimkunas Victoria , Veloso Artur , Hamel Martine , Stocco Rino , Mamane Yael , Li Zuomei , Young Jordan T.F. , Zinda Michael , Black W. Cameron
Published: May 2023

Supplementary Methods, Tables, Figures and References
Supplementary Tables from Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions
Authors: Carpenter Eileen S. , Elhossiny Ahmed M. , Kadiyala Padma , Li Jay , McGue Jake , Griffith Brian D. , Zhang Yaqing , Edwards Jacob , Nelson Sarah , Lima Fatima , Donahue Katelyn L. , Du Wenting , Bischoff Allison C. , Alomari Danyah , Watkoske Hannah R. , Mattea Michael , The Stephanie , Espinoza Carlos E. , Barrett Meredith , Sonnenday Christopher J. , Olden Nicholas , Chen Chin-Tung , Peterson Nicole , Gunchick Valerie , Sahai Vaibhav , Rao Arvind , Bednar Filip , Shi Jiaqi , Frankel Timothy L. , Pasca di Magliano Marina
Published: May 2023

Supplemental Table 1: Demographics and clinical data for donor Gife of Life Samples
Supplemental Table 2: Putative Ligand-Receptor pairs comparing all cell types from single cell sequencing of tumor samples compared to healthy samples.
Supplemental Table 3: Differential gene expression using linear mixed model analysis of cell types from spatial transcriptomic ROIs.
Supplemental Table 4: Kras mutational profiling on select donor samples
Supplemental Table 5: Antibodies used for multiplex immunofluoresence.
Supplemental Table 6: Antibodies and RNAScope probe used for co-IF/ISH.
Supplementary Figures Part 2 from Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions
Authors: Carpenter Eileen S. , Elhossiny Ahmed M. , Kadiyala Padma , Li Jay , McGue Jake , Griffith Brian D. , Zhang Yaqing , Edwards Jacob , Nelson Sarah , Lima Fatima , Donahue Katelyn L. , Du Wenting , Bischoff Allison C. , Alomari Danyah , Watkoske Hannah R. , Mattea Michael , The Stephanie , Espinoza Carlos E. , Barrett Meredith , Sonnenday Christopher J. , Olden Nicholas , Chen Chin-Tung , Peterson Nicole , Gunchick Valerie , Sahai Vaibhav , Rao Arvind , Bednar Filip , Shi Jiaqi , Frankel Timothy L. , Pasca di Magliano Marina
Published: May 2023

Supplementary Figures 11-14 and associated legends.
Supplementary Figures Part 1 from Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions
Authors: Carpenter Eileen S. , Elhossiny Ahmed M. , Kadiyala Padma , Li Jay , McGue Jake , Griffith Brian D. , Zhang Yaqing , Edwards Jacob , Nelson Sarah , Lima Fatima , Donahue Katelyn L. , Du Wenting , Bischoff Allison C. , Alomari Danyah , Watkoske Hannah R. , Mattea Michael , The Stephanie , Espinoza Carlos E. , Barrett Meredith , Sonnenday Christopher J. , Olden Nicholas , Chen Chin-Tung , Peterson Nicole , Gunchick Valerie , Sahai Vaibhav , Rao Arvind , Bednar Filip , Shi Jiaqi , Frankel Timothy L. , Pasca di Magliano Marina
Published: May 2023

Supplementary Figures 1-10 and associated legends
Data from Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.
Authors: Carpenter Eileen S. , Elhossiny Ahmed M. , Kadiyala Padma , Li Jay , McGue Jake , Griffith Brian D. , Zhang Yaqing , Edwards Jacob , Nelson Sarah , Lima Fatima , Donahue Katelyn L. , Du Wenting , Bischoff Allison C. , Alomari Danyah , Watkoske Hannah R. , Mattea Michael , The Stephanie , Espinoza Carlos E. , Barrett Meredith , Sonnenday Christopher J. , Olden Nicholas , Chen Chin-Tung , Peterson Nicole , Gunchick Valerie , Sahai Vaibhav , Rao Arvind , Bednar Filip , Shi Jiaqi , Frankel Timothy L. , Pasca di Magliano Marina
Published: May 2023

Abstract
The adult healthy human pancreas has been poorly studied given lack of indication to obtain tissue from the pancreas in the absence of disease and rapid postmortem degradation. We obtained pancreata from brain dead donors thus avoiding any warm ischemia time. The 30 donors were diverse in age and race and had no known pancreas disease. Histopathological analysis of the samples revealed PanIN lesions in most individuals irrespective of age. Using a combination of multiplex immunohistochemistry, single cell RNA sequencing, and spatial transcriptomics, we provide the first ever characterization of the unique microenvironment of the adult human pancreas and of sporadic PanIN lesions. We compared healthy pancreata to pancreatic cancer and peritumoral tissue and observed distinct transcriptomic signatures in fibroblasts, and, to a lesser extent, macrophages. PanIN epithelial cells from healthy pancreata were remarkably transcriptionally similar to cancer cells, suggesting that neoplastic pathways are initiated early in tumorigenesis.
Online parameter identification for equivalent circuit model of lithium-ion battery
Authors: Trung Nguyen Kien , Thi Diep Nguyen
Published: May 2023

Parameter identification is the most fundamental task for the model-based battery management system. However, there are some difficulties in completing this task since most of the existing methods require at least one known parameter or a time-consuming offline procedure to extract parameters from measured data. Based on the well-known thevenin equivalent circuit for battery, this paper determines the unique purpose is introducing the bounded varying forgetting factor recursive least square approach which identifies online all the parameters of the battery model at the same time. The precision of the proposed method is verified by simulation with the error converged to zero and the maximum error less than 1% of the nominal value.
Development of an adaptive finite impulse response filter optimization algorithm using rough set theory
Authors: M. Africa Aaron Don , Mercado John Arvin , Sim Joshua Kenichi
Published: May 2023

Signal processing is crucial that as one sends information, there is a corresponding process to encode, decode, and clean the signal of unwanted noise and disruptions via use of filters. Due to the environment and how unpredictable it can be and how noise can come from almost anywhere, the typical filter to be used are adaptive filters. Adaptive filters are non-linear filters and have been used regularly regarding adaptive signal processing, this means that the filter changes accordingly and adapts to the environmental noise surrounding it. The world today has numerous applications for adaptive filters such as channel equalization and acoustic noise cancellation. This incentivizes the further development of this specific technology and the constant research that is ongoing. The main component when it comes to adaptive filtering is the algorithms used for the filter. This research compares the least mean square (LMS) and recursive least square (RLS) algorithms concerning their effectiveness in filtering out unwanted acoustic noises. The paper will cover the design and implementation of an optimized rough set based adaptive finite impulse response (FIR) filter for acoustic noise cancellation. The microstrip and bowtie antenna were used to relay the data. The software MATLAB was used for the simulation.
Proposed enhanced link failure rerouting mechanism for software-defined exchange point
Authors: Abdullahi Abdijalil , Manickam Selvakumar , Karuppayah Shankar , Al-Shareeda Mahmood A.
Published: May 2023

Internet eXchange point (IXP) is a way to optimize network bandwidth. It enables a platform in the different providers like internet service providers (ISPs) and content delivery providers (CDNs) to share their traffic through a common point. A software defined exchange point (SDX) is an IXP comprising of a programmable deployed software defined network (SDN) switching fabric to enhance the management of their services, but they met the performance issues. The previous studies proposed various mechanisms and frameworks that tackled with these issues, but they don’t overcome overall challenges like link failure recovery for multi-hop-based SDX particularly packet processing delay and switch memory overhead. To cope with these issues, this paper proposed an enhanced link failure rerouting (ELFR) mechanism for multi-hop-based SDX. The objective of the proposed ELFR mechanism is to reduce the delay of packet processing to recover the link failure quickly and improve the path computation while ensuring the switch storage overhead. The present paper is an effort to retrospect and analyze the critical review of existing work for SDX. Furthermore, this paper provides a background of SDX, its components and its applications. Finally, this paper presents and compares the expected results of ELFR mechanism and related work.
Skin disease detection employing transfer learning approacha fine-tune visual geometry group-19
Authors: Habib Islam Md. Al , Shahriyar Sarkar Mohammad , Jahangir Alam Mohammad , Rahman Mushfiqur , Sarker Md Rahmatul Kabir Rasel
Published: May 2023

Your skin may become damaged by skin diseases and conditions. These illnesses can cause skin changes such as rashes, inflammation, itching, and other skin changes. While some skin conditions may run in families, others may result from a person’s way of life. Skin conditions may be treated with pills, creams, ointments, changes in diet, and lifestyle modifications. Deep learning algorithms for computer vision applications have advanced quickly thanks to a significant amount of data for training the model and advancements in evaluation of proposed that can provide stronger simplifications. Undesired skin disease regions are eliminated, quality is raised, and the disease is tinted by discarding artifacts, decrease noise, and improving the image. Three augmentation techniques have raised the quantity of skin disease images. The five transfer learning models and various convolutional neural network (CNN) architectures analyzed the augmentation dataset. Visual geometry group-19 (VGG-19) offers the highest level of accuracy. Following the segmentation of the dermoscopic images, the affected skin cells' features are extracted using a feature extraction technique. The retrieved features are stratified using a CNN classifier, that is focused in deep learning. The best outcomes were obtained using the hyper-tuned VGG-19, which had test and validation accuracy of 99.21% and 99.25%, including both.
Development of natural language processing on morphologybased Minangkabau language stemming algorithm
Authors: Sovia Rini , Defit Sarjon , Yuhandri Yuhandri , Sulastri Sulastri
Published: May 2023

Minangkabau language (ML) is one of the daily communication tools used by the people of West Sumatra, Indonesia. ML is a challenge in communicating. The ML language translation process is necessary to facilitate communication. This study aims to build a translation system for ML into Indonesian by developing the concept of natural language processing (NLP). NLP development adopts the performance of morphology-based Minangkabau language stemming algorithm (MLSA) which can separate basic words with affixes and endings. The research dataset adopts 600 basic ML words sourced from the big Minangkabau dictionary. The results of this study provide analytic output that can translate ML into Indonesian well. These results are presented based on the testing process on basic word input with an accuracy rate of 97.16% and based on text documents of 91.65%. Thus, the MLSA performance process presents the accuracy of the translation process. Based on these results, this research contributes to developing a stemming algorithm model in carrying out the process of removing prefixes, inserts, and suffixes in the Minangkabau language. Overall, this research can be useful as a tool for translating the ML into Indonesian.
Architectural framework and register-transfer level design synthesis for cost-effective smart eyewear
Authors: Malhotra Kashish , M. S. Revathi , B. V. Uma , K. M. Ajay
Published: May 2023

In today’s time more than 70% of the world’s population suffer from eye disnormalities leading to the usage of eyewear or spectacles. Integrating profound technologies with daily utilities could serve some of the issues improving and optimizing our lifestyle to the most. One such way is to infuse nanosized chip in eyewear i.e., powered spectacles or shades to detect the location of the spectacles whenever it is necessary. The nanosized chip proposed has features including self-designed Bluetooth operating digital circuit, timer logic, clock generation using astable multivibrator circuit, emergency button, beep alarm and impact sensor. The values of resistance and capacitace is calculated to be 18 K ohm and 47 uF to obtain 1 Hz frequency. An optimal pin placement arrangement is analyzed, and the timing waveform is simulated using Verilog as proof of logical working of the chip. 13 D flipflops have been calculated to refrain from eye related strains. This paper suggests a bottom-up approach and develops the architectural framework of the chip, its working flow, system on chip top-view, digital logic description of each block and its implementation using Verilog hardware description language (HDL). The complexity and computational cost of the designed chip is minimal thus being commercially viable.
Análise da vulnerabilidade dos solos quanto à erosão hídrica na bacia do Córrego Pequiá, Açailândia, Maranhão
Authors: Rizzo Felipe Alexandre , Silva Darllan Collins da Cunha e , Tonello Paulo Sergio
Published: May 2023

Este estudo objetivou através da Equação Universal de Perda de Solos (USLE) na Bacia do Córrego Pequiá, com extensão de área de 999,42 km² avaliar potencial processos erosivos. Foram gerados diferentes mapas temáticos para erosividade (fator R), erodibilidade (fator K), fator topográfico (fator LS) e conservação e manejo (fator CP) com utilização dos softwares ArcGIS 10.6, QGIS 2.8 e Trackmacker. Para o fator R utilizou-se a base histórica de 23 anos de dados de precipitação (1996-2018), obtendo o fator de erosividade médio de 7941 MJ.mm.h-1.ha-1 onde permitiu observar que as chuvas ocorridas no período chuvoso corresponderam a 95,09 % do total de erosividade. Já para o fator K a maior erodibilidade 0,0529 T ha h ha-1 MJ-1 mm-1 foi considerada para o Latossolo Amarelo, onde 70% da área da bacia do Córrego Pequiá poderá apresentar susceptibilidade à erosão laminar. No fator LS foi possível identificar a região norte da bacia com menores altitudes e declives. Para conservação e manejo, fator CP, poderá ocorrer o aumento dos processos erosivos caso as más práticas conservacionistas sejam continuadas. A perda média anual de solo foi estimada em 17.180,07 t/ha/ano que variou entre 12,65 e 34.349,4 t/ha/ano e as sub-bacias com maior potencial erosivo foram as do médio Pequiá e Mosquito. Concluiu-se que a perda de solo nos pontos mais críticos da bacia do córrego Pequiá se deve ao tipo de solo e manejo inadequado com altos índices pluviométricos.
Transformação e valorização do território: reflexões a partir da “Península” da Ponta d’Areia em São Luís (Maranhão)
Authors: Marques Matheus Andrade , Santos Saulo Ribeiro dos
Published: May 2023

A presente pesquisa discutiu o processo de transformação e valorização do espaço urbano de São Luís (Maranhão, Brasil), com ênfase para a realidade vigente na “Península” da Ponta d’Areia. Pois, este local da cidade passou ao longo das últimas décadas por um intenso fenômeno de transformação socioespacial, tendo como resultado deste, a reconfiguração de sua paisagem e alterações na sua dinâmica de uso e ocupação territorial. Deste modo, temos como objetivo de pesquisa analisar a relação do processo de transformação paisagística da referida área, com a sua valorização. Os procedimentos metodológicos foram executados através de abordagem qualitativa, com viés exploratório, realizando-se investigação bibliográfica e atividades de campo. Com relação aos resultados obtidos, constatou-se que em razão de uma série de investimentos seletivos do Estado e de agentes privados, foi possível a execução da transformação paisagística na “Península”, resultando assim na predominância de construções verticais neste ambiente e em sua consolidação como área residencial de alto padrão na cidade.
Ecoturismo e monitoramento de unidade de conservação: possibilidade de geração de renda e proteção ambiental no PETeR (GO), Brasil
Authors: Aguiar Junior Paulo Roberto Ferreira de , Barros Juliana Ramalho
Published: May 2023

A Lei Federal n° 9.985/2000, que instituiu o Sistema Nacional de Unidades de Conservação (SNUC), é foco de um debate em diversos campos sobre sua efetividade. As UCs se dividem em dois grupos: Proteção Integral (PI) e Uso Sustentável (US), sendo que o ponto mais significativo a diferi-las é a restrição em sua utilização. Entre as utilizações possíveis está o turismo, mais especificamente o ecoturismo. Esse segmento tem como alicerces a conservação ambiental, a geração de renda e a educação ambiental, o que coaduna com as orientações do SNUC. O objetivo deste trabalho é compreender a importância do ecoturismo nas Unidades de Conservação para a prática conservacionista da biodiversidade, assim como gerar receitas ao mesmo tempo. Ademais, apresenta as UCs como ferramentas de contenção do avanço da fronteira agrícola em áreas ainda não degradadas pela ação antrópica. Foi possível verificar, por meio do recorte espacial, Parque Estadual Terra Ronca (PETeR-GO), que este contribui para a conservação de espécies. O PETeR está localizado em uma área de tensão agrícola, na região Nordeste do Estado de Goiás, onde talvez o único empecilho de expansão seja o Parque. No que tange aos aspectos econômicos, não foi possível apresentar dados devido à falta de monitoramento, contudo, para tal reflexão foram utilizados trabalhos sobre as UCs federais que possuem monitoramento e, assim, foi possível estimar os ganhos com a visitação. Em vista do que se pensa sobre a prática ecoturista, bem como os objetivos das UCs, pode-se falar que há possibilidades concretas para a geração de renda e, também, para a conservação ambiental.
Aplicação da geofísica em estudos de arqueologia do lixo
Authors: Hatae Márcia , Elis Vagner Roberto , Andrade André Wagner Oliani
Published: May 2023

A garbologia é o ramo de pesquisa da arqueologia dedicado ao estudo analítico de resíduos deixados por uma dada população em busca de informações sobre seus costumes. Um dos desafios nesse tipo de estudo, também conhecido como arqueologia do lixo, é a necessidade de escavar lixões e aterros sanitários de estrutura desconhecida, de forma a obter a melhor amostragem com o menor custo possível. Este trabalho contribui para a solução desse problema, verificando a aplicabilidade da geofísica (métodos eletromagnéticos e elétricos) à determinação das melhores regiões a serem escavadas no Lixão de Mogi das Cruzes. A geofísica permitiu caracterizar as estruturas de subsuperfície, por meio dos parâmetros de condutividade e resistividade de diferentes materiais e estruturas, fornecendo a espessura da camada de resíduos em diferentes pontos e as respectivas profundidades do nível d’água, possibilitando a escolha das melhores regiões a serem escavadas. Posteriormente, os dados geofísicos foram comparados com as informações das escavações; verificou-se que este é um método bastante confiável, com a vantagem de ser não invasivo.
A vida de uma praia-lixão em São João del-Rei: processos transformativos e coisas em movimento
Authors: Araujo Reykel Diniz de
Published: May 2023

Durante a graduação em arqueologia na Universidade do Estado do Rio de Janeiro, em uma atividade avaliativa da disciplina “Prática de Campo I”, nos preocupamos em buscar compreender quais eram os processos formativos de uma faixa de deposição fluvial em São João del-Rei/MG que estava tomada de lixo. Na atividade investigamos o lugar utilizando princípios pioneiros de Michael Brian Schiffer para exercitar ferramentas da pesquisa arqueológica. Porém, essa narrativa percorre um caminho distinto neste trabalho. Seguindo ideias de William L. Rathje sobre pensar o lixo contemporâneo como fértil fonte de estudo para arqueologia e aproveitando o registro fenomenológico produzido no lugar que chamamos de “praia-lixão”, este artigo propõe discutir sobre o potencial pedagógico do lixo para cursos de formação em arqueologia e explorar a noção de vida das coisas de Tim Ingold em fruição com o lixo contemporâneo.
Apresentação do volume temático Arqueologia e os Estudos do Lixo
Authors: Souza Rafael de Abreu e , Agostini Camilla
Published: May 2023

O volume temático Arqueologia e os Estudos do Lixo traz para a cena o que poderíamos chamar de Lixologia, aportuguesando o neologismo em inglês Garbology /Garbologia. O lixo quando definido como restos, coisas descartadas, abandonadas, geralmente com conteúdos que estão intimamente ligados ao cotidiano, é um vestígio precioso para a Arqueologia. Encontrar um bolsão de lixo em contexto estratigráfico preservado é um dos melhores achados que a pesquisa arqueológica pode oferecer para quem está escavando um sítio. Com a expansão de uma arqueologia mais preocupada com a genealogia de problemas socioambientais que assolam a vida em todo planeta, o interesse arqueológico pelo lixo tem ressurgido e com ele novos olhares para os clássicos de William Rathje e o uso da arqueologia em políticas públicas, assim como tem sido cada vez mais comuma referência a autores cujas diferentes perspectivas teórico-metodológicas unem-se no que vem sendo chamado de arqueologia do passado contemporâneo, do passado recente ou do presente.
Vertical Convergence of Turbulent and Double-Diffusive Heat Flux Drives Warming and Erosion of Antarctic Winter Water in Summer
Authors: Giddy I. S. , Fer I. , Swart S. , Nicholson S.-A.
Published: May 2023

The seasonal warming of Antarctic Winter Water (WW) is a key process that occurs along the path of deep water transformation to intermediate waters. These intermediate waters then enter the upper branch of the circumpolar overturning circulation. Despite its importance, the driving mechanisms that mediate the warming of Antarctic WW remain unknown, and their quantitative evaluation is lacking. Using 38 days of glider measurements of microstructure shear, we characterize the rate of turbulent dissipation and its drivers over a summer season in the northern Weddell Sea. Observed dissipation rates in the surface layer are mainly forced by winds and explained by the stress scaling (r2 = 0.84). However, mixing to the base of the mixed layer during strong wind events is suppressed by vertical stratification from sea ice melt. Between the WW layer and the warm and saline circumpolar deep water, a subsurface layer of enhanced dissipation is maintained by double-diffusive convection (DDC). We develop a WW layer temperature budget and show that a warming trend (0.2°C over 28 days) is driven by a convergence of heat flux through mechanically driven mixing at the base of the mixed layer and DDC at the base of the WW layer. Notably, excluding the contribution from DDC results in an underestimation of WW warming by 23%, highlighting the importance of adequately representing DDC in ocean models. These results further suggest that an increase in storm intensity and frequency during summer could increase the rate of warming of WW with implications for rates of upper-ocean water mass transformation.

Significance Statement

Around Antarctica, the summer warming of the subsurface cold Antarctic Winter Water feeds the upper layer of the overturning circulation. This study aims to quantify the mechanisms that mediate the warming of Antarctic Winter Water. Our results reveal that the observed warming of this layer can be explained by both surface wind-driven mixing processes as well as double-diffusive convection occurring beneath the Winter Water layer. Understanding the role of these mechanisms is important for understanding the regions upper-ocean heat distribution, the rates of water mass transformation and how they might respond to changes in sea ice, stratification, and the overlying large-scale winds.
High Temporal Resolution Analyses with GOES-16 Atmospheric Motion Vectors of Mesovortex Rapid Intensification in Subtropical Cyclone Henri (2021)
Authors: Elsberry Russell L. , Feldmeier Joel W. , Chen Hway-Jen , Velden Christopher S.
Published: May 2023

Four-dimensional COAMPS dynamic initialization (FCDI) analyses with high temporal and spatial resolution GOES-16 atmospheric motion vectors (AMVs) are utilized to analyze the development and rapid intensification of a mesovortex about 150 km to the south of the center of the subtropical cyclone, Cyclone Henri (2021). During the period of the unusual Henri westward track along 30°N, the FCDI z = 300-m wind vector analyses demonstrate highly asymmetric wind fields and a horseshoe-shaped isotach maximum that is about 75 km from the center, which are characteristics more consistent with the definition of a subtropical cyclone than of a tropical cyclone. Furthermore, the Henri westward track and the vertical wind shear have characteristics resembling a Rossby wave breaking conceptual model. The GOES-16 mesodomain AMVs allow the visualization of a series of outflow bursts in space and time in association with the southern mesovortex development and intensification. Then the FCDI analyses forced by those thousands of AMVs each 15 min depict the z = 13 910-m wind field responses and the subsequent z = 300-m wind field adjustments in the southern mesovortex. A second northern outflow burst displaced to the southeast of the main Henri vortex also led to a strong low-level mesovortex. It was when the two outflow bursts joined to create an eastward radial outflow all along the line between them that the southern mesovortex reached maximum intensity and maximum size. In contrast to the numerical model predictions of intensification, outflow from the mesovortex directed over the main Henri vortex led to a decrease in intensity.
[De]Politicizing the Pandemic: Visually Communicating Digital Public Sociology
Authors: Robinson Laura , Trammel Juliana M. , Moles Katia
Published: May 2023

In the context of the COVID-19 “infodemic,” we explore discourse around a highly polarized health issue: mask wearing during the pandemic. Probing ideologically charged discourse from #masks on Twitter, we examine the potential for visual tools to promote digital citizen social science. Our case study reveals the promise of visualization to make ideological discourse on social media more easily identifiable by members of the general public. This leads us to argue that accessible visualization tools are needed for the public to ethically engage as digital citizen social scientists who actively analyze their own media consumption and outputs. Doing so would potentially awaken the sociological imagination by giving digital prosumers the agency to contextualize the social structure of debate around issues of public concern. In this way, visualizations of social media may ignite the sociological imagination in the tradition of digital public sociology.
A Standardized Protocol for Opioid Prescribing After Surgery Decreases Total Morphine Equivalents Prescribed
Authors: Millard Jessica L. , Hahn Elizabeth A. , Schumann Emily , Register Lindsey , Blackhurst Dawn , Carbonell Alfredo M. , Cobb William S. , Warren Jeremy A.
Published: May 2023

Introduction

Perioperative opioid analgesia has been extensively reexamined during the opioid epidemic. Multiple studies have demonstrated over prescription of opioids, demonstrating the need for change in prescribing practices. A standard opioid prescribing protocol was implemented to evaluate opioid prescribing trends and practices.

Objectives

To evaluate opioid use after primary ventral, inguinal, and incisional hernia repair and to assess clinical factors that may impact opioid prescribing and consumption. Secondary outcomes include the number of refills, patients without opioid requirement, difference in opioid use based on patient characteristics and adherence to prescribing protocol.

Methods

This is a prospective observational study examining patients undergoing inguinal, primary ventral and incisional hernias between February and November 2019. A standardized prescribing protocol was implemented and utilized for postoperative prescribing. All data was captured in the abdominal core health quality collaborative (ACHQC) and opioid use was standardized via morphine milligram equivalents (MME).

Results

389 patients underwent primary ventral, incisional, and inguinal hernia repair, with a total of 285 included in the final analysis. 170 (59.6%) of patients reported zero opioid use postoperatively. Total opioid MME prescribed and high MME consumption were significantly higher after incisional hernia repair with a greater number of refills were required. Compliance with prescribing protocol resulted in lower MME prescription, but not actual lower MME consumption.

Conclusions

Implementation of a standardized protocol for opioid prescribing after surgery decreases the total MME prescribed. Compliance with our protocol significantly reduced this disparity, which has the potential for decreasing abuse, misuse, and diversion of opioids by better estimating actual postoperative analgesic requirements.
The Value of Adding Scribe Services to 2 Distinct Pediatric Subspecialties in the Era of the Electronic Medical Record
Authors: Edwards Anne , Kanner Lauren , Tewar Shruti , Pesce Liuska , Leyser Marcio
Published: May 2023

To evaluate the impact of adding medical scribes to 2 distinct outpatient pediatric subspecialty clinics on provider burnout, visit length, and patient satisfaction. A total of 2 pediatric endocrinologists and 2 developmental-behavioral pediatrics/pediatrician (DBP) were randomly assigned based on days of the week to see patients aged 0 to 21 years in their clinics with and without in-person medical scribes from February 2019 to February 2020. Parent satisfaction rates were examined through pre- and postappointment surveys. Provider burnout rates were assessed through the Maslach Burnout Inventory-Human Services Survey. A retrospective comparative analysis of average appointment duration was undertaken considering the scribe/no scribe random allocation in the examination room. Funding for this pilot provided by the department of pediatrics budgeted funds. Over 2923 appointments during the project dates, 829 appointments were seen with a scribe. The average appointment time for a new DBP appointment was 61 minutes with scribes and 71 minutes without ( P < .001). Return patient appointments in DBP averaged 31 minutes with scribes and 43 minutes without ( P < .001). There was no significant difference in appointment duration for endocrinology with and without scribes. The average time for chart completion was reduced with the presence of scribes in DBP but not in endocrinology. Out of the 209 families surveyed, patient satisfaction rates with and without a scribe did not differ in that between 96% and 97% of respondents rated the appointment overall as “excellent” for each measure of provider communication with scribes present. Finally, from the Maslach Burnout Inventory-Human Services Survey, the average score across all 4 providers for Emotional Exhaustion and Depersonalization decreased during the project period, whereas Personal Accomplishment scores increased over the project period. Scribes might be more advantageous for some subspecialties that utilize prolonged narratives in clinic notes, like DBP, and an important avenue to consider in reducing provider burnout in busy ambulatory settings.
Public Perceptions of Juvenile Life Without Parole and Alternative Sentences: A Michigan Based Sample
Authors: Birnbaum Aliya , Murillo Miguel , Daftary-Kapur Tarika
Published: May 2023

Since the Supreme Court ruling in Miller banning mandatory juvenile life without parole (JLWOP) sentences, many states have gone one step further and completely eliminated JLWOP sentences. However, this trend has stagnated. One potential reason is society’s “tough on crime” framework, which legislators are hesitant to deviate from. To understand public opinion on adolescent adolescent development and sentencing of youth, we surveyed residents in one state considering legislation that would ban JLWOP and similar sentences, Michigan. Most participants had sufficient understanding of adolescent development and viewed adolescents as having the capacity for change. Additionally, most participants supported alternative sentences to JLWOP, with support primarily given to sentences that were rehabilitative in nature. Our results can help policymakers better understand their constituents’ beliefs regarding adolescent sentencing, which can inform policy decisions.
Evidence-Based Assessment in Special Education Research: Advancing the Use of Evidence in Assessment Tools and Empirical Processes
Authors: Talbott Elizabeth , De Los Reyes Andres , Kearns Devin M. , Mancilla-Martinez Jeannette , Wang Mo
Published: May 2023

Evidence-based assessment (EBA) requires that investigators employ scientific theories and research findings to guide decisions about what domains to measure, how and when to measure them, and how to make decisions and interpret results. To implement EBA, investigators need high-quality assessment tools along with evidence-based processes. We advance EBA in three sections in this article. First, we describe an empirically grounded framework, the Operations Triad Model (OTM), to inform EBA decision-making in the articulation of relevant educational theory. Originally designed for interpreting mental health assessments, we describe features of the OTM that facilitate its fusion with educational theory, namely its falsifiability. In turn, we cite evidence to support the OTM's ability to inform hypothesis generation and testing, study design, instrument selection, and measurement validation. Second, we describe quality indicators for interpreting psychometric data about measurement tools, which informs both the development and selection of measures and the process of measurement validation. Third, we apply the OTM and EBA to research in special education in two contexts: (a) empirical research for causal explanation and (b) implementation science research. We provide open data resources to advance measurement validation and conclude with future directions for research.
Daprodustat
Authors: Baker Danial E.
Published: May 2023

Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are available online to subscribers. Monographs can be customized to meet the needs of a facility. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service, contact Wolters Kluwer customer service at 866-397-3433.
Indigenizing, and Developing Africa: The Role of Indigenous Cultural Norms and Values
Authors: Aketema Joseph , Ladzepko Yao Joseph
Published: May 2023

The determinants of development of nation states are mostly skewed toward political serenity, abundance of natural resources, and the intellectual and managerial prowess of the human resource. However, the culture of a people and their values are very significant in the development of nation states even if they are yet to be nationalized in the polities of the African state. This article presents the empirical data that was obtained through interviews with traditional healers and herbalists within the Kasena-Nankana Municipality of Navrongo, and the Volta region, using the qualitative research method and a purposive sampling technique in order to explore the link between culture and development with particular focus in preserving and sustaining some natural resources such as fauna and flora species. It offers the emic insights of traditional healers and herbalists on how the increasing threat to cultural institutions affects the use of traditional medicine in Africa in general, and the aforementioned region in particular.