bluuebunny/crossref_metadata_2025 huggingface dataset:
Gradual Traction Reduction With the Ilizarov Method for Tile C1.2 Old Pelvic Fracture
Authors: Chen Hua , Wang Jin-Chang , Tang Jun-Jun , Guo Hao , Zhang Qun , Tang Pei-Fu , Lu Hai-Bo , Hu Xing-Xing , Dou Mei-Jing
Published: February 2023

Case:

A 20-year-old man with a Tile C1.2 pelvic fracture was treated with skeletal traction. After 3 months, the patient was unable to stand and walk, and the right lower limb was shortened by 7 cm. Radiographs showed that the sacroiliac joint dislocation was not reduced. Gradual traction reduction with the Ilizarov method was used to correct sacroiliac joint dislocation, and open internal fixation was performed. Postoperatively, the old pelvic fracture was successfully reduced without sacral plexus injury.

Conclusion:

Gradual traction reduction with the Ilizarov method can reduce the risk of sacral plexus injury and achieve satisfactory reduction of Tile C1.2 old pelvic fractures.
Étude paléographique de la section archaïque du Ms. Vaticano Arabo 13 (circa 9ème siècle)
Authors: Qabalan Hannah
Published: February 2023

Cet article présent consiste une étude paléographique dans le but d’essayer d’atteindre une datation approximative de la partie archaïque du ms. Vat. Ar. 13, pour résoudre les doutes à propos de l’époque qui appartient. Cela va être à travers une étude spécifique, scientifiques et technique basée sur des caractéristiques concrètes, c’est-à-dire, la typologie et la morphologie queportent ce ms. selon une description détaillée de ces graphèmes, ainsi que une analyse comparative avec d’autres mss. de la même tradition et zone, aussi des siècles entre VIII-X.
Orthography and Phonology in Vocalized Medieval Christian Arabic Gospel Manuscripts
Authors: Stokes Phillip W.
Published: February 2023

Pre-modern vocalized Arabic manuscripts can reveal a great deal about a variety of linguistic features represented in each text. Recent work has demonstrated the potential that vocalized manuscripts have, specifically for revealing aspects of the phonology of the corpora including the Quran, Judaeo-Arabic, and later ‘Middle Arabic’ texts. Christian Arabic texts, however, have been less frequently studied in this manner. Blau’s grammar of the Christian Arabic of south Palestine in the 9th/10th centuries CE4 draws primarily on unvocalized manuscripts, and therefore the phonological details he provides are inferred primarily from consonantal orthographic patterns. While a few others have focused on Christian Arabic manuscripts from the medieval period,6 there has been little work that undertakes a phonological description of vocalized Christian manuscripts in a thorough and systematic way.
BRENTJES, S. & FIDORA, A., Premodern translation, comparative approaches to cross-cultural transformations, contact and transmission, vol. 2, (Belgium: Brepols – Turnhout, 2021), 189 pp.
Authors: Qabalan Hanna
Published: February 2023

-
An automatic IoT based crop disease detection technique for early warning system using hybrid soft computing techniques
Authors: Venkatachalam Chandrasekar , Pandian N Rajesh , N Selvaganesh
Published: February 2023

The Indian economy is directly dependent on agricultural production. As the world grows and moves rapidly, identifying crop leaf diseases plays an important role in agriculture. Most of them are related to automation, and you also need to maintain the crop leaf with a little automation, and each crop has a specific need. To survive, it must be met, so companies need to develop systems that can communicate with their users. Currently, precision agriculture is being introduced to increase yields using the latest cutting-edge agriculture technology. An automatic disease detection system used to make instant and accurate decisions about plant diseases for farmers. This speeds up the diagnostic process. But in recent episodes, the show seemed a bit out of focus. One of these methods does not work well with the most important method, system diagnostics. In this paper, we propose an IoT based disease detection technique for crop using hybrid soft computing techniques (CDD-HSC). First, we segment the disease area from test leaf image using improved sunflower optimization (ISO) algorithm which is an important aspect for disease classification. Second, we introduce a multi-swarm snake optimization (MSSO) algorithm for optimal feature selection among multiple features in feature extraction stage. Then, we illustrates coach-learning induced capsule neural network (CL-CNN) for diseases classification in crop leaf with multi-classes. IoT concept used to transfer classification results to the corresponding former through mobile for immediate prevention in crop leaf diseases detecting, which limits the unwanted human delay. Finally, the performance of proposed CDD-HSC technique can analyze with different datasets and the results should sows the effectiveness of proposed method over existing methods in terms of accuracy, precision, F-measure and precision.
Clinical effects of continuity of nursing care for peripherally inserted central catheters among discharged cancer patients: A systematic review of randomized controlled trials
Authors: ye jindan , jin yawei , wang xiujuan , Tung Tao-Hsin
Published: February 2023

Background: The duration of peripherally inserted central catheter (PICC) retention can be shortened, and the likelihood of accidental extubation can increase if timely PICC maintenance is not performed after discharge. Furthermore, complications such as PICC blockage, phlebitis, and infection can occur without timely PICC maintenance after discharge. Therefore, providing PICC-catheterized individuals with continuous care after oncologic treatment is crucial. This systematic review and meta-analysis aimed to determine whether continuous care for patients with centrally located catheters can prolong catheter retention, enhance patients’ quality of life, and encourage healthy lifestyle practices.
Methods: The PRISMA criteria areguidelines for systematic reviews of relevant peer-reviewed literature. We conducted a randomized controlled trial to evaluate the effects of a continuum of care among patients with cancer. PubMed, the Cochrane Library, and Embase were searched for all relevant studies in English and Chinese until May 31, 2022. Two authors screened the included studies, evaluated eligible studies, and collected relevant data. They resolved any discordant opinions by asking for a senior editor's opinion. The Newcastle-Ottawa Scale tool was used for quality assessment, and the meta-analysis was performed using Review Manager version 5.3. A random-effects model was used when heterogeneitywas >50%. The estimates were expressed using hazard ratios and 95% confidence intervals (CI), and publication bias was assessed using funnel plots.
Results: This study included 21 papers (1420 in total were evaluated) in the systematic review. The PICC dwell time was recorded in 10 studies, three focused on quality of life, and six investigated healthy habits. Subgroup and sensitivity analyses were performed for the length of stay (mean difference (MD): 3.43; 95% CI [1.82, 5.04]) and health-promoting lifestyle profile (MD: 24.49; 95% CI [14.92, 34.05]) to reduce heterogeneity. However, these analyses had little impact on total heterogeneity.
Conclusions: This study observed that continuous care increased patients' quality of life, altered their manner of life, and extended PICC dwell time.
Tumor type and cell type-specific gene expression alterations in diverse pediatric central nervous system tumors identified using single nuclei RNA-seq
Authors: Lee Min Kyung , Azizgolshani Nasim , Shapiro Joshua , Nguyen Lananh , IV Fred Kolling , Zanazzi George , Frost Hildredth , Christensen Brock
Published: February 2023

Central nervous system (CNS) tumors are the leading cause of pediatric cancer death, and these patients have an increased risk for developing secondary neoplasms. Due to the low prevalence of pediatric CNS tumors, major advances in targeted therapies have been lagging compared to other adult tumors. We collected single nuclei RNA-seq data from 35 pediatric CNS tumors and three non-tumoral pediatric brain tissues (84,700 nuclei) and characterized tumor heterogeneity and transcriptomic alterations. We distinguished cell subpopulations associated with specific tumor types including radial glial cells in ependymomas and oligodendrocyte precursor cells in astrocytomas. In tumors, we observed pathways important in neural stem cell-like populations, a cell type previously associated with therapy resistance. Lastly, we identified transcriptomic alterations among pediatric CNS tumor types compared to non-tumor tissues, while accounting for cell type effects on gene expression. Our results suggest potential tumor type and cell type-specific targets for pediatric CNS tumor treatment. In this study, we address current gaps in understanding single nuclei gene expression profiles of previously uninvestigated tumor types and enhance current knowledge of gene expression profiles of single cells of various pediatric CNS tumors.
Relay Node Selection based on Adaptive Neuro- Fuzzy Inference System in Delay Tolerant Networks
Authors: semsarieh Fatemeh , Derakshanfard Nahideh
Published: February 2023

Delay tolerant networks (DTNs) are a type of mobile ad hoc network without the infrastructure in which a complete path from a source node to a destination does not exist always; so routing is the most important challenge in these networks. In recent years many routing methods in delay tolerant networks have been proposed. In previous methods, the copies were blindly forwarded to mobile nodes; finally, it caused a reduction in delivery rate and wasting of network resources. So it can be said choosing an appropriate relay node is an important challenge. In this paper, a novel Relay Node Selection by Adaptive Neuro-Fuzzy Inference System (SR-ANFIS) is proposed to improve the Delivery Ratio. In order to calculate the Chance of Receiving (CR), the parameters, Encounter Frequent (EF) to the destination, Selfishness Measure(SM), Closeness-Centrality (CC), Reach-Centrality (RC) are used as inputs of Adaptive Neuro-Fuzzy Inference System(ANFIS). Simulation results illustrate that the SR-ANFIS achieves better results in delivery ratio, delivery latency, message drop, overhead ratio and hop count than other exiting DTN routings.
Efficacy and Safety of ‘Dropless Vitrectomy Surgery’ and Comparison of Outcomes to Standard of Care Topical Therapy
Authors: CHALAM KAKARLA , Ahmed Harris
Published: February 2023

Objective/Background:
To compare the effectiveness of intravitreal injection of triamcinolone acetonide/moxifloxacin (Tri-Moxi) with the standard eye drop regimen for controlling postoperative inflammation, intraocular pressure, infections, macular thickness, and visual acuity (VA) in patients undergoing pars plana vitrectomy for various retinal disorders.
Subject/Methods:
In this retrospective longitudinal study, patients who underwent vitrectomy using intravitreal Tri-Moxi at the end of surgery (Group 1) were compared with those who received standard topical steroid antibiotics (Group 2) in terms of intraocular inflammation, intraocular pressure, and macular thickness based on optical coherence tomography.
Results
In total, 162 consecutive eyes (group 1 [81 eyes]; group 2 [82 eyes]) were included. VA improved by two lines in both groups at 90 days. In Group 1, preoperative VA (logMAR) was 0.92 (0.66) compared to 0.92 (0.75) in group 2 (p = 1), while at 3 months it was 0.61 (0.3) and 0.57 (0.3), respectively (p = 0.46). Group 1 showed superior outcomes with regard to central foveal thickness. The average central foveal thickness CFT ( µm) in group 1 preoperatively was 423 (95) and 348 (63) at 3 months compared to group 2 526 (109) and 306 (108) preoperatively and 3 months, respectively (p = 0.042). There was no statistically significant difference in the rate of elevated intraocular pressure between the two groups, and no cases of endophthalmitis were observed in either group.
Conclusions
Tri-Moxi is effective after vitrectomy and is not inferior to standard postoperative topical therapy.
Multimodal evoked potentials are useful for diagnosis of pediatric acute disseminated encephalomyelitis
Authors: JIN Mei , LIU JING , ZHANG MEIJIE , WANG YONGGANG , SUN SUZHEN
Published: February 2023

Background: The applying evoked potentials (EPs) to the diagnosis of acute disseminated encephalomyelitis (ADEM ) has not been investigated in detail. The aim of this study was to analyze multimodal evoked potentials in the early diagnostic value of pediatric ADEM.
Methods: Retrospective study enrolling pediatric ADEM patients and healthy controls (HCs) from neurology units between 2017 to 2021. They were measured with brainstem auditory evoked potentials (BAEPs), visual evoked potentials (VEPs) and somatosensory evoked potentials (SEPs), and then analyzed the early diagnostic value in ADEM patients.
Results: A total of 34 children with ADEM (mean age 6 years ; 23 males) and 30 HCs (mean age 6 years ; 17 males) were recruited.As magnetic resonance image (MRI) was the diagnostic criteria, the sensitivity, specificity and accuracy (κwas 0.88) of multimodal evoked potentials were highly consistent with those of MRI, the validity could be ranked in the following order with respect to the diagnosis of ADEM: multimodal evoked potentials＞single SEP＞single VEP＞single BAEP. Among 34 patients with ADEM, the abnormality of multimodal evoked potentials was 94.12％, while the abnormalities of single VEP, BAEP and SEP were 70.59％,64.71％and 85.3％,respectively, and there were significant differences between single VEP/BAEP and multimodal evoked potentials (c2=6.476/8.995, P=0.011/0.003).
Conclusion: The combined application of multimodal evoked potentials are superior to BAEP, VEP, or SEP alone in detecting the existence of central nerve demyelination, which would be applicable for the early diagnosis of ADEM.
Haplotype diversity of 17 Y-STR in the Iranian population
Authors: Eskandarion Mohammad Reza , Tabrizi Arash Alipour , Shirkoohi Reza , Raoofian Reza , Naji Masume , Pazhoomand Reza , Salari Hooman , Samadirad Bahram , Sabouri Alireza , Zohour Mostafa Montazer , Namazi Hadi , Baratieh Zohre , Farhadi Pegah , Sayyari Minoo , Dadgarmoghaddam Maliheh , Safdarian Esmat , Nikbakht Afrooz , Golshan Farnaz , Baybordi Fatemeh , Madhaji Elham , ShohodiFar Shadi , Tabasi Mohsen , Mohebbi Ramezan
Published: February 2023

In this study, we reported for the first time Y chromosome haplotypes throughout Iran from 1097 unrelated Iranian males using the AmpFlSTRTM YfilerTM kit. 1094 out of the 1097 haplotypes identified were unique. The values of haplotype diversity (HD) and discriminating capacity (DC) were 1.00000 and 0.997, respectively. An analysis of genetic distance was performed by the molecular variance (AMOVA) and multidimensional scaling plots (MDS), showing that a statistically was observed significant difference between the study population and previous data reported for other Iranian populations and other neighboring countries. The findings of the present study are likely to be useful for Forensic casework analysis and kinship investigations.
Picosecond laser trepan drilling of vertical sidewalls micro-holes for 631 stainless steel
Authors: Gu Zehui , He Yuyang , Ji Jinghu , Fu Yonghong
Published: February 2023

Ultrashort-pulse laser is widely used in drilling micro-hole (diameter<100μm) because of its higher energy density and less thermal effect. However, ultrashort-pulse laser drilling still has some defects, such as taper, poor entrance edge quality, etc. In this paper, the method of trepanning drilling was used to process micro-holes (the entrance diameter was about 55μm) on the stainless steel sheet (the thickness was 80μm) with a picosecond laser. The taper (7.63º ~ -1.8º) of the micro-hole was successfully adjusted by changing the laser angle of incidence (AOI) and laser energy. The experimental results showed that the entrance roundness increased from 85.2% to 94.1% with the increase of the AOI. In addition, the entrance roundness decreased with the rise of the laser fluence. Observing the hole wall surface showed that the remelts and micro-cracks on the hole wall surface increased with the increase of the AOI. The remelts and micro-cracks on the hole wall surface were obviously reduced when the laser fluence was increased. In summary, AOI and laser energy are essential parameters to adjust the geometric size of the hole. By optimizing the AOI and fluence parameters, the taper of the hole can be controlled (from positive taper to negative taper), and the morphology of the entrance and exit of the hole can be improved.
Evaluating YouTube as a Source of Patient Information for Pediatric Tracheostomy Care
Authors: DUYMAZ Yasar Kemal , Şahin Şamil , Erkmen Burak , Uzar Tuğçe , Önder Serap
Published: February 2023

Purpose:To evaluate YouTube's usefulness as a source of information concerning pediatric tracheostomy care.
Materials and Methods: On August 10, 2022, the top 50 YouTube search results for "pediatric tracheostomy care" were displayed. Each “video was evaluated by a jury of three otolaryngologists with at least 2 years of professional experience in pediatric otolaryngology using DISCERN, scoring system of Journal of the American Medical Association (JAMA), and the Global Quality Score (GQS).
Results:After exclusion criteria 24 videos were evaluated. Fifteen of the evaluated videos were produced by health professionals, and the other nine videos were produced by independent users. The average duration of the video was 337.5 seconds, varying between 82 seconds and 1364 seconds. The average Discern score of videos produced by health professionals was 38.9 ± 13, compared to 36.6 ± 14 for independent users. The mean JAMA score was 1.04 ± 0.68 for health professionals and 1.11 ± 0.94 for independent users. The GQS score was 2.82 ± 0.73 for health professionals and 3.19 ± 0.84 for independent users. There was no statistically significant difference between the two groups for Discern, JAMA, and GQS scoring.
Conclusion:YouTube does not seem to be a good option for parents to get useful information about pediatric tracheostomy care at this time. Health professionals should provide websites with high-quality materials to improve awareness of pediatric tracheostomy care.
High-pressure homogenization of gelatin Alteration of the physicochemical and interfacial properties of gelatin after high-pressure homogenization
Authors: Heidary Atiyeh , Soltanizadeh Nafiseh
Published: February 2023

The aim of the present study was to investigate the effects of high-pressure homogenization (HPH) on the functional, physicochemical, and structural properties of gelatin. Regarding this goal, gelatin was prepared at concentrations of 3, 6, and 9% and homogenized at 100 MPa via single, double, and triple passes. The FTIR and sulfhydryl content results indicated that HPH could destroy hydrogen bonds, leading to the protein unfolding after a single HPH cycle. Based on the CD spectroscopy, the structural packing of gelatin was altered after HPH treatment. Also, the bathochromic shift of gelatin λmax at UV spectra confirmed protein unfolding after a single pass. As a result of this process, the microstructure of gelatin gel was altered, and the pore shape changed from a polygon, a well-oriented shape to an unordered structure. The protein unfolding could increase emulsifying and foaming capacity and stability. In contrast, the strain sweep and temperature sweep of gels indicated that the HPH treatment of gelatin had an undesirable effect on gel strength and decreased the elasticity and viscosity of the gel. Therefore, HPH will be a promising method to promote the functional properties of gelatin for its application in the food industry.
Impact Analysis of Delayed Updates for Decentralized Federated Learning: A Delay-tolerant Training Strategy Perspective for Real-world Edge Intelligence
Authors: Zeng Yong , Liu Siyuan , Xu Zhiwei , Tian Jie
Published: February 2023

Decentralized Federated learning is a distributed edge intelligence framework by exchanging parameter updates instead of training data among participators, in order to retrain or fine-tune deep learning models in a peer to peer way. Considering the various topologies of edge networks, the impact of transmission delay of updates during model training is non-negligible for data-intensive intelligent applications at edge, e.g., intelligent medical services, automated driving vehicles etc.. To address this problem, we analyze the impact of delayed updates for decentralized federated learning, and provide a theoretical bound for these updates to achieve model convergence. In addition, we propose novel decentralized federated learning (delay-adaptive-DFL) to enhance the corporate strategy of edge computing devices. It releases the requirement for aggregating the model updates of edge devices in a fixed time period. Within the theoretical bound of updating period, the latest versions for the delayed updates are reused to continue aggregation, in case that the model parameters from a specific neighbor are not collected or updated in time. Regarding four neural network models, we implement experiments on a real-world test bed, and demonstrate that delay-adaptive-DFLis more efficient than the latest baselines.
A Systematic Review to Introduce the Most Effective Postbiotic Derived from Probiotics for Aflatoxin Detoxifications
Authors: Zamanpour Setayesh , Noori Seyyed Mohammad Ali , Yancheshmeh Behdad Shokrollahi , Afshari Asma , Hashemi Mohammad
Published: February 2023

Introduction: Aflatoxins are one of the most dangerous mycotoxins that have created challenges in the field of food safety. Different chemical, biological, and physical techniques were studied to detoxify aflatoxins in vegetable and animal foods. Among the biological methods is microbial detoxification. Some microorganisms, especially probiotic bacteria, play a key role in reduction of aflatoxin. Simultaneously with the remarkable progress in this field, the researchers got acquainted with the new concept of postbiotics, which explains to some extent the exact mechanism of detoxification of probiotics. The purpose of this study is to find the aflatoxin removal percentage by postbiotics and to find the most effective postbiotic. Materials and Methods: In this review article, studies that tested the effect of probiotics-derived postbiotics on aflatoxin detoxification in vitro were collected from databases. All the articles related to experimental studies were included in the study and the articles without full text or were not consistent with our study were excluded from the study. Results: It seems that out of all the postbiotics under investigation, the postbiotic derived from Lactobacillus kefiri, Lactobacillus kefiri, Lactobacillus rhamnosus, Lactobacillus rhamnosus, Saccharomyces cerevisiae probiotic bacteria is the most effective postbiotic with 97.22%, 95.27%, 86.2%, 81.4%, and 100% inhibitory effect against Aflatoxin B1, B2, G1, G2, and M1. Conclusion(s): Therefore, postbiotics derived from probiotic bacteria can be used as a safe anti-aflatoxin agent in a wide range of food products to control toxins and promote health.
Integrative analysis of a Novel six methylated pseudogene Prognostic signature in patients with glioma
Authors: Chen Zhigang , Zhou Jialin , Wang Bingran , Li Jiahui , Xie Han , Zhao JiaJia , Liu Jun , Tian Dasheng , Bian Erbao
Published: February 2023

Background: Gliomas are the most common malignant tumor of the central nervous system(CNS). Dysregulated pseudogene expression was significantly associated with the prognosis of glioma patients. However, the role of abnormal methylation of pseudogenes in glioma prognosis has not yet been studied. This study aimed to develop a novel six-methylated pseudogenes signature to predict the prognosis of glioma patients.
Methods: Based on lasso regression analysis, a risk signature for six methylated pseudogenes was constructed. Next, a prognostic nomogram including grade, age, gender, and radiation was constructed. Besides, the immune cell infiltration analyses of patients based on the six-methylated pseudogenes were performed. Meanwhile, consensus cluster analysis of six methylated pseudogenes identified two glioma patient subgroups. Furthermore, GO, KEGG and GSEA were used to analyze related genes. Finally, the ability of glioma to proliferate, migrate and invade was used to verify subsequent functions.
Results: In this study, six gene models consisting of methylated pseudogenes were identified and validated, and showed strong prognostic power in the training dataset, validation dataset, and entire dataset. The calibration diagram showed good predictive performance. In addition, the proportion of B cells and CD4+T cells was significantly higher in the high-risk group, while the proportion of mono cells was lower. By silencing the expression of SBF1P1 and SUMO1P1, the ability of glioma to proliferate, migrate, and invade can be inhibited.
Conclusions: The six-methylated pseudogene signature may be a novel predictor for prognostic assessment of glioma patients, which could accurately predict patient prognosis.
Removal of Norfloxacin antibiotic from wastewater by adsorption onto SnS 2 followed by photocatalysis
Authors: Kar Sayani , Pal Tanusri , Ghosh Surajit
Published: February 2023

Antibiotic remainders found in the river water of many countries have been a significant threat to the environment and human health. Herein, the removal of Norfloxacin antibiotic from the aqueous medium has been reported. We successfully synthesized SnS2 nanoplates and studied the removal of Norfloxacin aqueous medium by adsorption followed by photocatalysis process using SnS2. The presence of pores on SnS2 surface and excellent photo-induced charge generation ability under solar light illumination makes it a potential material for the degradation of Norfloxacin from an aqueous medium. 80% of Norfloxacin was degraded in 130 minutes, out of which 36.7% was removed in 20 min by the adsorption process and the rest was degraded in 110 min photo catalytically. The scavenger experiments were also performed to determine the reactive species responsible for the photodegradation. The results identified that the holes play a dominating role in the photodegradation of Norfloxacin by SnS2 in the aqueous medium. Our study has established SnS2 as a promising material for the removal of water pollutants, which may be a pathway to protect the environment from antibiotic pollution in river water.
Fluorescent Aptasensor Based on Fe3O4@PPy
Authors: Jiao Zhe , Jiao Shaohe , Wang Yueting , Chen Weibin , Xie Yangzi , Zhang Xiaolin , Yi Long
Published: February 2023

In this work, nanomaterial polypyrrole-coated magnetite nanoparticles (Fe3O4@PPy) was synthesized and combined with label free nucleic acid probe for aptasensing. Two kinds of nucleic acid probes were applied, including blue emissive 1,1,2,2-tetrakis [4-(2-bromo-ethoxy) phenyl] ethene (TTAPE) and red emissive malachite green. The two probes can be interacted with the aptamer to form aptasensor by label free strategy. Fe3O4@PPy not only adsorbed aptamer by electrostatic interaction as well as the π–π bonding and hydrogen bonding (between PPy coating and the phosphate backbone of DNA), but also quenched the fluorescence of fluorescent probes. Upon addition of target compounds, the aptasensor was away from Fe3O4@PPy and magnetic separated thus lower background noise was obtained. The turned-on photoluminescence (PL) emission intensity was recorded and showed linearity to the concentrations of targets. The aptasensor was applied to detect metal ions, small molecular acetamiprid, and thrombin protein by changing different aptamers. The robustness of method was proved by application in real samples including vegetables (for detection of acetamiprid, LODs 0.02 and 0.04 ng/L), serum samples (for detection of thrombin, LODs 5.5 and 4.3 nM) and water samples (for detection of Pb, LOD 0.17 nM). The recoveries ranged from 81 to 105%, with RSDs ranged from 4.3 to 9.2%. Given its high selectivity and sensitivity, this technique can be used as a general detection platform for clinical and environmental applications.
A comparison study of ancient and modern wheat: Characterization and sensory analysis of an ancient Anatolian wheat Triticum dicoccum (Kavilca) grown in Kars, Türkiye
Authors: Aydar Elif Feyza , Demircan Evren , Mertdinç Zehra , Kahraman Tülay , Yaman Hümeyra , Salantur Ayten , Çetiner Buket , Özçelik Beraat
Published: February 2023

The ancient wheat varieties have been ignored due to efforts to increase the yield of modern wheat. In recent years, interest in ancient wheat has increased for various reasons. This study aimed to characterize the ancient Anatolian wheat Triticum turgidum ssp. dicoccum (Kavilca) from Kars, Türkiye and to compare it with modern bread wheat Triticum aestivum in terms of quality parameters, mineral and fatty acid profile, total flavonoid content (TFC), and antioxidant activity (TAA). Quality parameters were conducted with standardized methods. Mineral and fatty acid profiles were determined with inductively coupled plasma mass spectrometry and gas chromatography, respectively. Spectrophotometric methods were used to determine TFC and TAA. Triangular test and Quantitative Descriptive Profile method were applied for sensory analyses. Novel findings of this study were low gluten quality (p < 0.05), low Al content (2.85–5.16 mg/kg dw, p < 0.05), and high TFC (3.65 mg RE/g dw, p < 0.05) of Kavilca along with similar overall liking sensory score (p > 0.05) compared to modern bread. There was a strong sensory difference with a 99.9% probability between modern and 15% Kavilca added bread. Characterization and especially, sensory analysis results might be a reference for the food industry to integrate Kavilca into several bakery products.
Effect of P-glycoprotein Inhibition on Temozolomide Chemosensitivity on the Neuroblastoma Cell Line Sh-sy5y
Authors: KARADEMİR Mustafa
Published: February 2023

Neuroblastoma is one of the most common and deadly childhood solid tumors. P-glycoprotein (P-gp) pump plays a role in developing resistance to many chemotherapeutic agents. The high expression of P-gp is associated with poor prognosis in drug resistance and neuroblastoma treatment. We aimed to evaluate the anticancer effect of Temozolomide (TMZ) on the SH-SY5Y human neuroblastoma cell line in the presence of P-gp inhibitor Verapamil (VER). In the present study, the antiproliferative effect of TMZ on SH-SY5Y cells alone and in combination with VER was evaluated using a colorimetric XTT viability test. SH-SY5Y cells were seeded to 96 well plates at 10,000 cells/well. TMZ (100 µM-10 mM) and VER (0.25-10 µg/ml) were applied to the cells alone first, then XTT measurements were performed after 24 and 48 hours. In the study's second phase, VER was applied to the cells at the fixed concentration of 2.5 µg/ml to block P-gp pumps, then increasing concentrations of TMZ were applied to the cells in the presence of VER. The current study showed that in addition to cytotoxic effects, VER + TMZ administration was found to accelerate apoptosis in SH-SY5Y cells compared to TMZ utilization alone. The wound healing assay demonstrated that VER + TMZ combination also inhibited cell migration. In light of this evidence, combining TMZ with VER in the neuroblastoma cell line may inhibit migration and cell proliferation via the apoptosis pathway and produce a substantial anticancer effect.
Effect of copper azole preservative on the laminate’s surface wettability and interlaminar shear performance of preservative treated Glulam
Authors: Yang Xiaojun , Liu Jiamin , Wang Chaojie , Kong Xiaohui
Published: February 2023

Copper azole (CA) preservative applied to glulam improves the durability of glulam. The purpose of this study is to evaluate the effect of CA preservative on the surface bonding quality of laminates under different surface conditions. Surface morphology and wettability of CA preservative treated laminate were investigated. A comparison was also made of interlaminar shear performance obtained from preservative treated glulam under different environmental conditions. The results indicate that CA preservative adheres to wood fibers and occupies part of wood voids, which has a significant adverse effect on water permeability of preservative treated laminate. Planing can effectively improve the surface wettability of preservative treated laminate. CA preservative tiny particles on the planed laminate surface are distributed relatively uniformly, and the proportion is smaller than that of the unplaned laminate. The interlaminar shear strength of preservative treated glulam made of planed laminates is at least 15% higher than that of the glulam made of unplaned laminates. No matter in hot and humidity environment or natural aging tests, preservative treated glulam glued by resorcinol formaldehyde (RF) adhesive performed better than that by polyurethane (PUR) adhesive. It is recommended that in order to obtain a reliable preservative treated glulam quality, the 0.6mm planing of laminate and RF adhesive are required.
Development of Disaster Response Strategies for Multi-Disasters
Authors: Tsai Meng-Han , Chan Yi-Lin
Published: February 2023

The purpose of this research is to develop a disaster response strategy that can be used when more than one disaster happens at the same time. When different types of disasters occur at the same time, disaster response operations will become extremely complex. It is difficult for responders to directly perform response operations based on a single standard operation procedure. This research used flooding events that occurred in Taiwan during the COVID pandemic as an example case to develop the response strategies. The standard operating procedures before and after the pandemic were first reviewed. The authors also joined the response operations to have close observations on how responders execute response operations under restrictions of the pandemic. User interviews were then conducted to collect feedback from four responders. Finally, the multi-disaster response strategies, coined as OPERATE, was developed based on results of procedure review, field observations, and user interviews. OPERATE was developed for disaster response teams to smoothly execute response operations when multiple disasters occur simultaneously. It includes seven perspectives: simplified operation, flexible procedures, adjustable environment, personalized reminder, positive attitude, well-developed decision support tool, and preparatory education. OPERATE is developed to reduce the impact of multi-disasters on response teams, including the impact of the disaster itself and orders issued by other government departments in response to other disasters. Following the developed strategies, disaster response teams are expected to conduct stable and efficient operations in the context of multiple disasters.
Comprehensive analysis of prognostic value and immune infiltration of CDK1 in lung cancer
Authors: Zhu Yunying , Yu Qinhua , Lei Chenshuang , Qiu Liannv
Published: February 2023

Objective:
Lung cancer is one of the common malignant tumors worldwide with poor prognosis. Cyclin dependent kinase 1 (CDK1) plays crucial roles in regulating of cell cycle transition and is mainly involved in the development and progression of various tumors, however, little is known about its function in lung cancer.
Methods:
The Cancer Genome Atlas (TCGA), Gene Expression Profiling Interactive Analysis (GEPIA), Clinical Proteomic Tumor Analysis Consortium (CPTAC) and Human Protein Atls (HPA) were used to evaluate the level of CDK1. Kaplan-Meier (K-M) Plotter, receiver operating characteristic (ROC) curve and Cox regression analyses were used to evaluate the value of CDK1 in lung cancer. Gene functional and pathways were assessed using Gene ontology (GO) analysis and gene set enrichment analysis (GSEA) The immune infiltration analysis was investigated basing on Single-sample gene set enrichment analysis (ssGSEA) .
Results:
The expression of CDK1 was significantly upregulatedin lung cancer patients, especially in those with advanced stage. Elevated CDK1 was associated with advanced clinical stage, shorter overall survival (OS) and disease specific survival (DSS) in lung cancer. Moreover, the functions of CDK1 were primarily related to cell cycle regulation and immune response. Most interestingly, the expression of CDK1 was associated with the infiltration immune cells and immune checkpoints.
Conclusions:
Our results revealed that CDK1 may be a diagnostic and prognostic biomarker in lung cancer. CDK1 plays a role in tumor immune evasion and may provide a potential therapeutic target to overcome immunity resistance in lung cancer.
Examination of alternative eGFR definitions on the performance of deep learning models for detection of chronic kidney disease from fundus photographs
Authors: An Songyang , Vaghefi Ehsan , Yang Song , Xie Li , Squirrell David
Published: February 2023

Deep learning (DL) models have shown promise in detecting chronic kidney disease (CKD) from fundus photographs. However, previous studies have utilized a serum creatinine-only estimated glomerular rate (eGFR) equation to determine CKD despite the existence of more accurate methods. In this study, we used the UK Biobank as a test and validation dataset to demonstrate an incremental and statistically significant improvement in model performance for predicting CKD when using a creatinine and cystatin C eGFR equation over a creatinine-only equation. Attempts to directly compare our results with the results from existing DL models is complicated due to significant differences in the composition of the dataset, particularly in the incidence rate of confounding risk factors. We hypothesize that existing eGFR equations' limitations in accurately identifying CKD and the paucity of retinal features uniquely indicative of CKD may contribute to the observed differences in model performance, highlighting the need for more principled research to quantify the effects of dataset distribution on DL models' ability to predict CKD from fundus photographs.
Primary Dural Lymphoma Case Report: A Distinct Subtype of Primary Central Nervous System Lymphoma
Authors: Sushanth Sreenivasan , Risha Solanki , Kancharla Pragnan , Khan Cyrus , Samhouri Yazan
Published: February 2023

Primary CNS lymphoma (PCNSL) is an aggressive form of extranodal non-Hodgkin lymphoma that arises in the brain parenchyma, eyes, meninges, or spinal cord in the absence of systemic disease. Primary dural lymphoma (PDL) arises from the dura mater of the brain. It differs biologically from other CNS lymphomas. It is usually a low-grade B-cell marginal zone lymphoma (MZL), whereas other types of PCNSL are usually high-grade large B-cell lymphoma. This specific pathological subtype has important therapeutic and prognostic implications, making PDL a distinct subtype of PCNSL. Herein, we report a case of PDL in an African American patient who presented with chronic headaches. MRI of the brain showed a dural-based homogeneously enhancing extra-axial mass along the left hemisphere and was contained within the anterior and parietal dural matter. The malignant cells stained diffusely positive for CD19, CD20, and CD22 but negative for CD5, CD10, Cyclin D1, and CD56. Ki67 was 10–20%, consistent with extranodal marginal zone lymphoma. Given the location and pathology, the patient was diagnosed with PDL. She was started on treatment with bendamustine and rituximab. Due to Marginal Zone Lymphoma’s indolent nature, location outside the blood brain barrier, and known efficacy of bendamustine-rituximab, we decided to treat our patient with Bendamustine-Rituxumab. She completed six cycles, and post-therapy MRI brain showed complete remission. Our case adds to the sparse literature about primary dural lymphoma.
Osmotic regulation of free amino acid for adaptation to high salt in razor clam
Authors: Deng Min , Wang Honglei , Du Xinxin , Yuan Li , Li Yifeng , Niu Donghong
Published: February 2023

Free amino acids play an important role in osmotic regulation induced by high salt. In order to study the effect of free amino acids on the osmotic regulation of Sinonvacula constricta cells, the salinity was set at 20 and 32 in control group and experimental group. In the experimental group, proline, taurine and alanine amino acid solid powder with concentration of 5ug/ml was added. Serum and cell samples were taken from each group at different time points for detection by osmotic pressure and detection by flow cytometry. In summary, we found that serum osmolality, total free amino acid and single free amino acid content increased with the increase of salt stress, and remained at a high level. Under high salt conditions, the osmotic pressure in S. constricta could not equilibrate with the seawater environment. In the later stages of stress, the gap between the two gradually widened. Under the condition of amino acid addition, the osmotic pressure is gradually the same as that of foreign seawater. Furthermore, the mean number of fluorescent channels produced by high salt downflow cytometry was significantly lower than that of the other amino acid groups. Among the three amino acids, proline has the largest accumulation in the S. constrictaand the shortest regulation time for osmotic balance. It has been shown that free amino acids can help better osmotic regulation of hypersaline S. constricta. The results of this study provide a reference for exploring the physiological mechanism of the amino acid on salt tolerance in bivalves.
Agent-based management and coordination of aircraft at intersections
Authors: OUASSAM ELHOUCINE , DABACHINE YASSINE , HMINA NABIL , BOUIKHALENE BELAID
Published: February 2023

This work presents a game-theoretic approach to address the problem of coordination and scheduling of aircraft at intersections, with the goal of avoiding conflicts and potential collisions. The proposed algorithm enables simple agents to work together in a way that leads to cooperative behaviors, resulting in equilibria that improve the overall efficiency of the system. The researchers tested and compared the game-theoretic approach with a centralized approach, specifically First-Come-First-Serve (FCFS), using data from Mohammed 5 Casablanca airport. The initial results suggest that the game-theoretic model is promising, despite its higher complexity. The approach has the potential to improve the overall coordination and scheduling of aircraft, leading to a more efficient and safe system. The proposed game-theoretic approach is designed to improve the coordination and scheduling of aircraft at intersections, ultimately leading to a safer and more efficient system. The approach is shown to be promising in initial testing, offering a potentially superior alternative to centralized approaches like FCFS. This research highlights the potential benefits of game-theoretic models in addressing complex coordination problems in multi-agent systems.
Molecular mechanism of CCDC106 regulating the p53-Mdm2/MdmX signal axis
Authors: Zhou Ting , Cheng Xiyao , Ke Zhiqiang , Ma Qianqian , Xiang Jiani , Gao Meng , Huang Yongqi , Su Zhengding
Published: February 2023

The tumor suppressor p53 (p53) is regulated by murine double minute 2 (Mdm2) and its homologous MdmX in maintaining the p53 basal level. The overexpressed Mdm2/MdmX inhibit the cellular p53 activity, highly relevant to cancer occurrence. The coiled-coil domain-containing protein 106 (CCDC106) has been identified as a p53-interacting partner. However, its molecular mechanism is still elusive. Here we show that CCDC106 functions as a signaling regulator of the p53-Mdm2/MdmX axis mediated by cellular p53. We identified that CCDC106 directly interacts with the p53 transactivation domain by competing with Mdm2 and MdmX. The CCDC106 overexpression downregulates the cellular level of p53 and Mdm2/MdmX, and the decreased p53 reversibly downregulates the cellular level of CCDC106. Our work not only provides a molecular mechanism of CCDC106 regulating the cellular levels of p53 and Mdm2/MdmX, but also suggests that the CCDC106-p53 interaction as a novel target for cancer therapy.
The connection between Capital structure and performance: Does firm size matter?
Authors: Mansour Marwan , Kamel Al Zobi Mo’taz , Al-Naimi Ahmad , Daoud Luay
Published: February 2023

The purpose of this paper is to empirically investigate the impact of capital structure decisions on firm performance in Jordan (2010–2018), as well as the extent to which firm size matters in the capital structure-performance relationship. The dependent variable was market share. The main independent variables were the book value of total debt ratios, and firm-specific factors such as firm size, firm age, firm growth, and market-to-book value of equity served as control variables. This study used a quantitative research method using panel data analysis of 830 firm-year observations. Random effects model was employed to analyze the capital structure-performance nexus. To infer correctly, the main analysis was re-examined using the generalized method of moment estimator to overcome possible endogeneity concerns. After controlling for endogeneity and firm heterogeneity, this study finds that the book value of capital structure has a signiﬁcantly positive relation to a firm’s market share. Hence, every one unit increase in the book value of total debt ratios will increase market share by 4.77%. The firm size, sales growth, and market-to-book value of equity had a signiﬁcantly positive association with market share. Hence, every one unit increase in firm size, growth and market-to-book equity ratio will increase a firm’s market share by 8.84%, 2.06%, and 2.15%, respectively, but surprisingly, firm age did not meaningfully contribute to operating performance. Another important finding was that the strength of a positive relationship between the book value of total debt ratios and market share depends on the size of a firm and is mostly higher for larger-sized firms. Hence, every one unit increased in the book value of total debt ratios for large firms will increase market share by 10.58%.
Evaluation of Reinforcement Corrosion in Cementitious Composites Modified with Water Treatment Sludge
Authors: Rezende Mariana , Gromboni Pedro , Corradini Patricia , Sales Almir , Mascaro Lucia
Published: February 2023

The water treatment sludge (WTS) is a residue composed of organic and inorganic matter in a solid, liquid, and gaseous state that has a variable composition concerning its physical, chemical, and biological characteristics. The irregular disposal of WTS can promote harmful changes to the environment, such as reduction of dissolved oxygen and increase in the concentration of aluminum and other metals in the receiving watercourses. To propose a suitable purpose for this residue, this work evaluated the physical and mechanical properties of the concrete and corrosion resistance of the reinforcement in a cementitious composite using WTS in replacement to the natural sand. A conventional concrete and a conventional mortar were used as a reference and a 3% WTS-content concrete, and a 3% WTS-content mortar were prepared to evaluate the WTS influence in mechanical properties and corrosion resistance. By electrochemical measurements, it was observed that the resistance of the cementitious matrix was not altered by WTS addition. Regarding steel resistance, the WTS may promote a higher susceptibility to frame corrosion, which can be correlated to the lower pH than reference medium (REF). The concrete reinforcement characterization indicates that concretes with WTS can be used as reinforced concrete structure in urban areas.