bluuebunny/crossref_metadata_2025 huggingface dataset:
Three main stages in the uplift of the Tibetan Plateau during the Cenozoic period and its possible effects on Asian aridification: A review
Authors: Wang Zhixiang , Shen Yongjin , Pang Zhibin
Published: June 2018

Abstract. The Tibetan Plateau uplift and its linkages with the evolution of the Asian climate during the Cenozoic are a research focus for numerous geologists. Here, a comprehensive review of tectonic activities across the Tibet shows that the development of the Tibetan Plateau has undergone mainly three stages of the uplift: the near-modern elevation of the central Tibet and significant uplift of the northern margins (~ 55–35 Ma), the further uplift of the plateau margins (30–20 Ma), and a rapid uplift of the plateau margins again (15–8 Ma). The first uplift of the plateau during ~ 55–35 Ma forced the long-term westward retreat of the Paratethys Sea. The high elevation of the central Tibet and/or the Himalayan would enhance rock weathering and erosion contributing to lowering of atmospheric CO2 content, resulting in global cooling. The global cooling, sea retreat coupled with the topographic barrier effect of the Tibetan Plateau could have caused the initial aridification in central Asia during the Eocene time. The second uplift of the northern Tibet could have resulted in the onset of the East Asian winter monsoon as well as intensive desertification of inland Asia, whereas the central-eastern in China became wet. The further strengthening of the East Asian winter monsoon and the inland Asian aridification during 15–8 Ma was probably associated with the Tibetan Plateau uplift and global cooling. Therefore, the uplift of the Tibetan Plateau plays a very important role in the Asian aridification.
Technical note: A low-cost albedometer for snow and ice measurements – theoretical results and application on a tropical mountain in Bolivia
Authors: Condom Thomas , Dumont Marie , Mourre Lise , Sicart Jean Emmanuel , Rabatel Antoine , Viani Alessandra , Soruco Alvaro
Published: June 2018

Abstract. This study presents a new instrument called a low-cost albedometer (LCA)
composed of two illuminance sensors that are used to measure in situ
incident and reflected illuminance values on a daily timescale. The ratio
between reflected vs. incident illuminances is called the albedo index and can be compared with actual albedo values. Due to the shape of the
sensor, the direct radiation for zenith angles ranging from 55 to 90∘
is not measured. The spectral response of the LCA varies with the solar
irradiance wavelengths within the range 0.26 to 1.195 µm, and the
LCA detects 85 % of the total spectral solar irradiance for clear sky
conditions. We first consider the theoretical results obtained for 10
different ice and snow surfaces with clear sky and cloudy sky incident solar
irradiance that show that the LCA spectral response may be responsible for an
overestimation of the theoretical albedo values by roughly 9 % at most.
Then, the LCA values are compared with two “traditional” albedometers, which are CM3
pyranometers (Kipp & Zonen), in the shortwave
domain from 0.305 to 2.800 µm over a 1-year measurement period
(2013) for two sites in a tropical mountainous catchment in Bolivia. One site
is located on the Zongo Glacier (i.e., snow and ice surfaces) and the second
one is found on the crest of the lateral moraine (bare soil and snow
surfaces), which present a horizontal surface and a sky view factor of 0.98.
The results, at daily time steps (256 days), given by the LCA are in good
agreement with the classic albedo measurements taken with pyranometers with
R2=0.83 (RMSD = 0.10) and R2=0.92 (RMSD = 0.08) for the
Zongo Glacier and the right-hand side lateral moraine, respectively. This
demonstrates that our system performs well and thus provides relevant
opportunities to document spatiotemporal changes in the surface albedo from
direct observations at the scale of an entire catchment at a low cost.
Finally, during the period from September 2015 to June 2016, direct
observations were collected with 15 LCAs on the Zongo Glacier and
successfully compared with LANDSAT images showing the surface conditions of
the glacier (i.e., snow or ice). This comparison illustrates the
efficiency of this system to monitor the daily time step changes in the
snow and ice coverage distributed on the glacier. Despite the limits imposed by
the angle view restrictions, the LCA can be used between 45∘ N and
45∘ S during the ablation season (spring and summer) when the melt
rate related to the albedo is the most important.
Evaluation of the atmosphere-land-ocean-sea ice interface processes in the Regional Arctic System Model Version 1 (RASM1) using local and globally gridded observations
Authors: Brunke Michael A. , Cassano John J. , Dawson Nicholas , DuVivier Alice K. , Gutowski Jr. William J. , Hamman Joseph , Maslowski Wieslaw , Nijssen Bart , Reeves Eyre J. E. Jack , Renteria Jose C. , Roberts Andrew , Zeng Xubin
Published: June 2018

Abstract. The Regional Arctic System Model version 1 (RASM1) has been developed to provide high-resolution simulations of the Arctic atmosphere-ocean-sea ice-land system. Here, we provide a baseline for the capability of RASM to simulate interface processes by comparing retrospective simulations from RASM1 for 1990–2014 with the Community Earth System Model version 1 (CESM1) and the spread across three recent reanalyses. Evaluations of surface and 2-m air temperature, surface radiative and turbulent fluxes, precipitation, and snow depth in the various models and reanalyses are performed using global and regional datasets and a variety of in situ datasets, including flux towers over land, ship cruises over oceans, and a field experiment over sea ice. These evaluations reveal that RASM1 simulates precipitation that is similar to CESM1, reanalyses, and satellite-gauge combined precipitation datasets over all river basins within the RASM domain. The possible reasons for this result are discussed. Snow depth in RASM is closer to upscaled surface observations over a flatter region than in more mountainous terrain in Alaska. The sea ice interface is well simulated in regards to radiation fluxes which generally fall within observational uncertainty. RASM1 surface temperature and radiation biases are shown to be due to biases in the simulated mean diurnal cycle. Development of RASM2 aims to address these biases.
Dual-polarized quantitative precipitation estimation as a function of range
Authors: Simpson Micheal J. , Fox Neil I.
Published: June 2018

Abstract. Since the advent of dual-polarization radar technology, many
studies have been conducted to determine the extent to which the
differential reflectivity (ZDR) and specific differential phase shift (KDP)
add benefits to estimating rain rates (R) compared to reflectivity (Z)
alone. It has been previously noted that this new technology provides
significant improvement to rain-rate estimation, primarily for ranges within
125 km of the radar. Beyond this range, it is unclear as to whether the
National Weather Service (NWS) conventional R(Z)-convective algorithm
is superior, as little research has investigated radar precipitation estimate performance
at larger ranges. The current study investigates the performance of three
radars – St. Louis (KLSX), Kansas City (KEAX), and Springfield (KSGF), MO –
with 15 tipping bucket gauges serving as ground truth to the radars. With
over 300 h of precipitation data being analyzed for the current study, it
was found that, in general, performance degraded with range beyond,
approximately, 150 km from each of the radars. Probability of detection (PoD) in
addition to bias values decreased, while the false alarm rates increased as
range increased. Bright-band contamination was observed to play a potential
role as large increases in the absolute bias and overall error values near
120 km for the cool season and 150 km in the warm season. Furthermore,
upwards of 60 % of the total error was due to precipitation being falsely
estimated, while 20 % of the total error was due to missed precipitation.
Correlation coefficient values increased by as much as 0.4 when these
instances were removed from the analyses (i.e., hits only). Overall, due to
the lowest normalized standard error (NSE) of less than 1.0, a National Severe
Storms Laboratory (NSSL) R(Z,ZDR) equation was determined to be the most
robust, while a R(ZDR,KDP) algorithm recorded NSE values as high as 5. The
addition of dual-polarized technology was shown to estimate
quantitative precipitation estimates (QPEs) better
than the conventional equation. The
analyses further our understanding of the strengths and limitations of the
Next Generation Radar (NEXRAD) system overall and from a seasonal perspective.
A manera de presentación No. 9
Authors: Rivas Ramón D.
Published: June 2018

Revista de Museología "Kóot" No.9 2018: 5-6
Ecotoxicity of disinfectant benzalkonium chloride and its mixture with antineoplastic drug 5-fluorouracil towards algaPseudokirchneriella subcapitata
Authors: Elersek Tina , Ženko Maja , Filipič Metka
Published: June 2018

Background

Benzalkonium chloride (BAC) is one of the most common ingredients of the disinfectants. It is commonly detected in surface and wastewaters where it can interact with the residues of pharmaceuticals that are also common wastewater pollutants. Among the latter, the residues of antineoplastic drugs are of particular concern as recent studies showed that they can induce adverse effect in aquatic organisms at environmentally relevant concentrations.

Methods

Ecotoxicity of BAC as an individual compound and in a binary mixture with an antineoplastic drug 5-fluorouracil (5-FU) was determined towards algaPseudokirchneriella subcapitata,a representative of primary producers.The toxicity of the BAC+5-FU binary mixture was predicted by the two basic models: concentration addition (CA) and independent action (IA), and compared to the experimentally determined toxicity. Additionally combination index (CI) was calculated to determine the type of interaction.

Results

After 72 h exposure to BAC a concentration dependent growth inhibition ofP. subcapitatawas observed with an EC500.255 mg/L. Comparing the predicted no effect concentration to the measured concentrations in the surface waters indicate that BAC at current applications and occurrence in aquatic environment may affect algal populations. The measured toxicity of the mixture was higher from the predicted and calculated CI confirmed synergistic effect on the inhibition of algal growth, at least at EC50concentration. The observed synergism may have impact on the overall toxicity of wastewaters, whereas it is less likely for general environments because the concentrations of 5-FU are several orders of magnitude lower from its predicted no effect concentration.

Discussion

These results indicate that combined effects of mixtures of disinfectants and antineoplastic drugs should be considered in particular when dealing with environmental risk assessment as well as the management of municipal and hospital wastewaters.
The effects of noncontingent music and response interruption and redirection on vocal stereotypy
Authors: Gibbs Ashley R. , Tullis Christopher A. , Thomas Raven , Elkins Brittany
Published: June 2018

Vocal stereotypy is a commonly occurring challenging behavior in children with autism spectrum disorder (ASD) that is frequently maintained by automatic reinforcement and often interferes with skill acquisition. Matched stimulation (MS), and response interruption and redirection (RIRD) are two interventions that have been demonstrated to be effective in reducing the occurrence of vocal stereotypy with participants with ASD. The current study sought to determine if the combination of MS (noncontingent music) and RIRD was more effective at reducing vocal stereotypy than RIRD alone and if the parents of children with ASD found the combination of MS and RIRD more socially valid than RIRD alone. The results suggested that the combined intervention resulted in greater suppression of vocal stereotypy and increased occurrences of on‐task behavior in both participants. Additionally, RIRD required fewer implementations and had a shorter duration when combined with MS. Results suggest that the combination of MS and RIRD may be an effective intervention outside of highly controlled settings.
In Defense of the “Conventional Account” of the Jus ad Bellum
Authors: Bridgeman Tess
Published: June 2018

States sometimes choose to break the law. International lawyers should seek to understand instances of illegality, particularly when they involve the unlawful use of force. But should we also shift our understanding of legality itself in an attempt to bring state conduct within the fold? In particular, what should we make of uses of force that seem to enjoy some degree of international political support while straying from the law governing the resort to force, or the jus ad bellum? Monica Hakimi asks this timely, and indeed timeless, question in her thought-provoking article arguing for a reconceptualization of “The Jus ad Bellum’s Regulatory Form.” Hakimi argues that we must carefully examine state engagement with the UN Security Council, including when it is not authorizing force, to fully understand state behavior. This claim is uncontroversial. However, she also argues that Council activity short of authorizing force can nevertheless establish legality and the Council's “institutional processes can deprive the general standards [that constitute the jus ad bellum] of their legal effect.” The empirical validity and normative desirability of this more provocative claim deserve close interrogation.
Informal Regulation and the Hyper-Responsiveness of International Law
Authors: Reinold Theresa
Published: June 2018

Monica Hakimi has offered a thought-provoking and timely analysis of how the jus ad bellum operates, placing on the agenda of international legal scholarship a regulatory dynamic that has thus far remained underappreciated. While I believe that a discussion of this dynamic is overdue and thus welcome her plea to take informal regulation seriously, I find some of her underlying assumptions about the nature and function of international law problematic. Therefore, rather than applaud the manifold insightful points Hakimi makes, this essay zeroes in on two related assumptions in her article that I find questionable: first, Hakimi's reasoning about the law-creating effects of informal regulation and, on a related note, the distinction between legality and legitimacy; and second, her tendency to embrace uncritically the particularistic nature of informal regulation. Both points implicate what I term the “hyper-responsiveness” of the law, that is, the (problematic) notion that every momentary political constellation should be reflected in the content of the law. In embracing law's hyper-responsiveness, Hakimi's article sidesteps a discussion of the ambivalent implications of informal regulation.
Let's get Physical: Supporting Arts Based Research through Haptic Learning
Authors: Jones Chris
Published: June 2018

What is a materials collection? Why is it in the library? The aim of this paper is to introduce the idea of a materials collection as a result of explorations in arts based research. This involved theorizing ideas of materiality, haptic engagement with objects and relating them to the creative process within a library environment. The collection is a response to a perceived gap between theory and creative practice expressed within the student cohort. The risk to the library comprises a possible erosion of value in the student experience, in that the service becomes marginalized in contrast to the studio based activities. The nature of the research undertaken by the student cohort at the University for the Creative Arts is considered, and the development of the materials collection is presented as a response to this inquiry. The collection forms the site of haptic learning: the sensual engagement with the world is combined with a phenomenological approach to create a space within which the relationship of theory and practice may be developed.
MONOTONE LIPSCHITZIAN SEMIGROUPS IN BANACH SPACES
Authors: KOZLOWSKI WOJCIECH M.
Published: June 2018

We prove the existence of common fixed points for monotone contractive and monotone nonexpansive semigroups of nonlinear mappings acting in Banach spaces equipped with partial order. We also discuss some applications to differential equations and dynamical systems.
SHIDLOVSKY’S MULTIPLICITY ESTIMATE AND IRRATIONALITY OF ZETA VALUES
Authors: FISCHLER STÉPHANE
Published: June 2018

In this paper we follow the approach of Bertrand–Beukers (and of Bertrand’s later work), based on differential Galois theory, to prove a very general version of Shidlovsky’s lemma that applies to Padé-approximation problems at several points, both at functional and numerical levels (that is, before and after evaluating at a specific point). This allows us to obtain a new proof of the Ball–Rivoal theorem on irrationality of infinitely many values of the Riemann zeta function at odd integers, inspired by the proof of the Siegel–Shidlovsky theorem on values of $E$-functions: Shidlovsky’s lemma is used to replace Nesterenko’s linear independence criterion with Siegel’s, so that no lower bound is needed on the linear forms in zeta values. The same strategy provides a new proof, and a refinement, of Nishimoto’s theorem on values of $L$-functions of Dirichlet characters.
THE -CENTRE AND GRADABLE DERIVED EQUIVALENCES
Authors: COULEMBIER KEVIN , MAZORCHUK VOLODYMYR
Published: June 2018

We propose a generalisation for the notion of the centre of an algebra in the setup of algebras graded by an arbitrary abelian group $G$. Our generalisation, which we call the $G$-centre, is designed to control the endomorphism category of the grading shift functors. We show that the $G$-centre is preserved by gradable derived equivalences given by tilting modules. We also discuss links with existing notions in superalgebra theory.
Beta-blocker use and cardiovascular event risk in patients with heart failure with preserved ejection fraction
Authors: Tsujimoto Tetsuro , Kajio Hiroshi
Published: June 2018

To assess whether beta-blocker use is associated with cardiovascular events and mortality in patients with heart failure with preserved ejection fraction (HFpEF), this study analyzed the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial data using Cox proportional hazard models. Adjusted HRs for composite cardiovascular events in all patients and in patients without previous MI were significantly higher for those on beta-blockers than for those not on beta-blockers (Hazard ratio [HR] for all patients 1.23, 95% confidence interval [95% CI] 1.02–1.49; HR for patients without previous MI 1.35, 95% CI 1.08–1.70), whereas that for patients with previous MI was not significantly different (HR 1.06, 95% CI 0.74–1.54). Additionally, cardiovascular event risk in propensity score-matched patients without previous MI was significantly higher in those on beta-blockers than in those not on beta-blockers. Risks of all-cause death, major cardiovascular events, and heart failure hospitalization were significantly higher in those on beta-blockers than in those not on beta-blockers. Beta-blocker use in HFpEF patients, particularly those without previous MI, was associated with increased risk of unfavorable cardiovascular events.
Initiating a mild aqueous electrolyte Co3O4/Zn battery with 2.2 V-high voltage and 5000-cycle lifespan by a Co(iii) rich-electrode
Authors: Ma Longtao , Chen Shengmei , Li Hongfei , Ruan Zhaoheng , Tang Zijie , Liu Zhuoxin , Wang Zifeng , Huang Yan , Pei Zengxia , Zapien Juan Antonio , Zhi Chunyi
Published: June 2018

Rechargeable aqueous zinc–cobalt oxide batteries with high voltage, excellent rate capability and long-cycling life.
Identification and field attraction of the female sex pheromone of a kiwifruit pest, Nokona feralis (Lepidoptera: Sesiidae)
Authors: Naka Hideshi , Kubota Seiichi , Kuchiki Fumitaka , Shibasaki Hiroshi , Yamamoto Masanobu , Soejima Yasuyoshi , Arita Yutaka , Ando Tetsu
Published: June 2018

Female sex pheromone of a clearwing moth Nokona feralis (Leech) (Lepidoptera: Sesiidae), a pest of kiwifruit, was identified to be a 7:3 mixture of (3E,13Z)-3,13-octadecadienyl acetate (E3,Z13-18:OAc) and (3E,13Z)-3,13-octadecadien-1-ol (E3,Z13-18:OH) by GC-EAD and GC/MS analyses. Males were attracted to wide-range mixtures of E3,Z13-18:OAc and E3,Z13-18:OH, and a 7:3 mixture of those two compounds strongly attracted the males in the field.
Identification and Characterization of Phomopsis amygdali and Botryosphaeria dothidea Associated with Peach Shoot Blight in Yangshan, China
Authors: Tian Yanli , Zhao Yuqiang , Sun Ting , Wang Lv , Liu Jun , Ma Xiaofeng , Hu Baishi
Published: June 2018

Peach (Prunus persica (L.) Batsch) is produced locally in Yangshan, Wuxi City, China. In recent years, a widespread shoot blight has been observed in many peach orchards of Yangshan that kills the twigs and results in high losses in fruit production. Disease incidences ranged from 10 to 20% in the affected orchards and, in extreme cases, 40% of the trees were affected. Shoot blight of peach is caused by a fungus, previously identified as Phomopsis amygdali. Between 2014 and 2015, samples were collected four times from three peach orchards located in Yangshan to understand the etiology of shoot blight. Interestingly, two types of shoot blight symptoms were observed: one characterized by necrotic lesions with rings and one without rings. Based on conidial morphology, cultural characteristics, and analysis of nucleotide sequences of three genomic regions (the internal transcribed spacer region, a partial sequence of the β-tubulin gene, and the translation elongation factor 1-α), isolates were identified as P. amygdali and Botryosphaeria dothidea. Remarkably, most of the P. amygdali isolates were recovered from twigs showing necrotic lesions without rings. In contrast, most of the B. dothidea isolates were recovered from twigs with rings in the necrotic lesions. Correlations among pathogens, sampling regions, and disease symptoms were noted, and growth rates of these pathogens were characterized. Pathogenicity tests showed that B. dothidea isolates could induce necrotic lesions with rings but P. amygdali isolates could only induce necrotic lesions. Moreover, the B. dothidea isolates exhibited higher levels of virulence than P. amygdali isolates on the peach twig. Additionally, high frequencies of detection of both P. amygdali and B. dothidea from buds indicated that buds may be the primary site of fungal invasion. Cankers and necrotic twigs may also serve as infection courts. Our results suggest that B. dothidea and P. amygdali are the common causal agents of peach shoot blight in Yangshan, China. This finding provides a basis for the development of effective management strategies.
Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS
Authors: Hacker Carolin , Cai Xiaofeng , Kegler Carsten , Zhao Lei , Katharina Weickhmann A. , Bode Helge B. , Wöhnert Jens
Published: June 2018

Several peptides in clinical use are derived from non-ribosomal peptide synthetases (NRPS). In these systems multiple NRPS subunits interact with each other in a specific linear order mediated by docking domains (DDs) to synthesize well-defined peptide products. In contrast to these classical NRPSs, the subunits of rhabdopeptide/xenortide producing NRPSs can act iteratively and in different order resulting in libraries of peptide products. In order to define the structural and thermodynamic basis for their unusual interaction patterns, we determined the structures of all N-terminal DDs (NDDs) as well as of an NDD-CDD complex and characterized all putative DD interactions thermodynamically for one such system. Key amino acid residues for DD interactions were identified that upon their exchange not only changed the DD affinity but also resulted in rationally predictable changes in peptide production. A simple set of ‘recognition rules’ for DD interactions was identified that also operates in other megasynthase complexes.
Systems genetic discovery of host-microbiome interactions reveals mechanisms of microbial involvement in disease
Authors: Bubier Jason A. , Philip Vivek M. , Quince Christopher , Campbell James , Zhou Yanjiao , Vishnivetskaya Tatiana , Duvvuru Suman , Blair Rachel Hageman , Ndukum Juliet , Donohue Kevin D. , Phillips Charles , Foster Carmen M. , Mellert David J. , Weinstock George , Culiat Cymbeline T. , Baker Erich J. , Langston Michael A. , O’Hara Bruce , Palumbo Anthony V. , Podar Mircea , Chesler Elissa J.
Published: June 2018

The role of the microbiome in health and disease involves complex networks of host genetics, genomics, microbes and environment. Identifying the mechanisms of these interactions has remained challenging. Systems genetics in the laboratory mouse enables data-driven discovery of network components and mechanisms of host-microbial interactions underlying multiple disease phenotypes. To examine the interplay among the whole host genome, transcriptome and microbiome, we mapped quantitative trait loci and correlated the abundance of cecal mRNA, luminal microflora, physiology and behavior in incipient strains of the highly diverse Collaborative Cross mouse population. The relationships that are extracted can be tested experimentally to ascribe causality among host and microbe in behavior and physiology, providing insight into disease. Application of this strategy in the Collaborative Cross population revealed experimentally validated mechanisms of microbial involvement in models of autism, inflammatory bowel disease and sleep disorder.

eTOC Blurb

Host genetic diversity provides a variable selection environment and physiological context for microbiota and their interaction with host physiology. Using a highly diverse mouse population Bubier et al. identified a variety of host, microbe and potentially disease interactions.

Highlights

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18 significant species-specific QTL regulating microbial abundance were identified

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Cis and trans eQTL for 1,600 cecal transcripts were mapped in the Collaborative Cross

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Sleep phenotypes were highly correlated with the abundance ofB.P. Odoribacter

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Elimination of sleep-associated microbes restored normal sleep patterns in mice.
Two faces of decentralization in South Korea
Authors: Koo Jun , Kim Byoung Joon
Published: June 2018

Purpose

The purpose of this paper is to review historical progress and current picture of decentralization in Korea from political, administrative and fiscal perspectives.

Design/methodology/approach

This paper draws on economic as well as political theories regarding decentralization and describes historical development of the local autonomy system in Korea.

Findings

This paper discusses the current discrepancies among the progress of political, administrative and fiscal independence in the local autonomy system in Korea and concludes that the lack of fiscal independence in the local level significantly undermines the efficacy of political and administrative decentralization in Korea.

Originality/value

Decentralization has three distinct perspectives. This paper examines decentralization in Korea from all three perspectives.
A study of e-Research and its relation with research data life cycle: a literature perspective
Authors: Gupta Shivam , Müller-Birn Claudia
Published: June 2018

Purpose

The traditional means of pursuing research by having all the parameters and processes under one roof has given way to collaborative mechanisms of performing the same task. Collaborative work increases the quality of research and it is a big contributing factor to augment the growth of the scientific knowledge. This process leads to training of new and well-informed academicians and scientists. e-Research (Electronic Research) has gained significant amount of traction as technology serves as the backbone for undertaking collaborative research. The purpose of this paper is to provide a synoptic view of existing research surrounding e-Research and suggest a data lifecycle model that can improve the outcome of collaborative research.

Design/methodology/approach

Systematic literature review methodology has been employed to undertake this study. Using the outcome of the literature review and the analysis of the existing data lifecycle models, an improvised version of the data lifecycle model has been suggested.

Findings

This study has brought a conceptual model for data lifecycle for collaborative research. The literature review in the domain of e-Research has shown that the focus of these papers was on the following stages of data lifecycle model: concept and design, data collection, data processing, sharing and distribution of data and data analysis.

Research limitations/implications

In this paper, only journal papers have been considered and conference proceedings have not been included for literature review.

Originality/value

This paper suggests a conceptual model for the data lifecycle for collaborative research. This study can be useful for academic and research institutions to design their data lifecycle model.
Maintenance scheduling based on PROMETHEE method in conjunction with group technology philosophy
Authors: Abdelhadi Abdelhakim
Published: June 2018

Purpose

The purpose of this paper is to implement a strategic decision-making framework by selecting clusters of maintainable machines and scheduling their maintenance as part of a company’s manufacturing strategy.

Design/methodology/approach

Multi-criteria clustering problem in conjunction with the application of a group technology is used to establish clusters of maintainable machines based on their need for maintenance according to the type of failures they can encounter.

Findings

Using the concept of group technology in conducting preventive maintenance will result in the grouping of machines according to the impact of a failure based on the criteria specified by the decision makers. Accordingly, it will facilitate the process of executing the maintenance itself by ordering spare parts and informing the maintenance personnel which will lead to minimize the maintenance cost.

Originality/value

The results presented in this paper are reliable, objective may be used to minimize the total cost of conducting preventive maintenance in a manufacturing environment.
Curcumin prevents the bile reflux‐induced NF‐κB‐related mRNA oncogenic phenotype, in human hypopharyngeal cells
Authors: Vageli Dimitra P. , Doukas Sotirios G. , Spock Todd , Sasaki Clarence T.
Published: June 2018

The presence of bile is not an uncommon finding in acidic oesophageal and extra‐oesophageal refluxate, possibly affecting the hypopharyngeal mucosa and leading to neoplastic events. We recently demonstrated that acidic bile (pH ≤ 4.0) can induce NF‐κB activation and oncogenic mRNA phenotype in normal hypopharyngeal cells and generate premalignant changes in treated hypopharyngeal mucosa. We hypothesize that curcumin, a dietary inhibitor of NF‐κB, may effectively inhibit the acidic bile‐induced cancer‐related mRNA phenotype, in treated human hypopharyngeal primary cells (HHPC), supporting its potential preventive use in vivo. Luciferase assay, immunofluorescence, Western blot, qPCR and PCR microarray analysis were used to explore the effect of curcumin in HHPC exposed to bile (400 μmol/L) at acidic and neutral pH. Curcumin successfully inhibited the acidic bile‐induced NF‐κB signalling pathway (25% of analysed genes), and overexpression of NF‐κB transcriptional factors, c‐REL, RELA(p65), anti‐apoptotic bcl‐2, oncogenic TNF‐α, EGFR, STAT3, WNT5A, ΔNp63 and cancer‐related IL‐6. Curcumin effectively reduced bile‐induced bcl‐2 overexpression at both acidic and neutral pH. Our novel findings suggest that, similar to pharmacologic NF‐κB inhibitor, BAY 11‐7082, curcumin can suppress acidic bile‐induced oncogenic mRNA phenotype in hypopharyngeal cells, encouraging its future in vivo pre‐clinical and clinical explorations in prevention of bile reflux‐related pre‐neoplastic events mediated by NF‐κB.
Modeling the
Pseudomonas
Sulfur Regulome by Quantifying the Storage and Communication of Information
Authors: Larsen Peter E. , Zerbs Sarah , Laible Philip D. , Collart Frank R. , Korajczyk Peter , Dai Yang , Noirot Philippe
Published: June 2018

Bacteria sense and respond to their environments using a sophisticated array of sensors and regulatory networks to optimize their fitness and survival in a constantly changing environment. Understanding how these regulatory and sensory networks work will provide the capacity to predict bacterial behaviors and, potentially, to manipulate their interactions with an environment or host. Leveraging the information theory provides useful quantitative metrics for modeling the information processing capacity of bacterial regulatory networks. As our model accurately predicted gene expression profiles in a bacterial model system, we posit that the information theory-based approaches will be important to enhance our understanding of a wide variety of bacterial regulomes and our ability to engineer bacterial sensory and regulatory networks.
Cloud Baking
Authors: Liu Chang , Ooi Wei Tsang , Jia Jinyuan , Zhao Lei
Published: June 2018

We propose Cloud Baking, a collaborative rendering architecture for dynamic Web3D scenes. In our architecture, the cloud renderer renders the scene with the global illumination (GI) information in a GI map; the web-based client renderer renders the scene with ambient lighting only and blends it with the GI map received from the cloud for the final scene. This approach allows the users to interact with the web scene and change the scene dynamically through the web interface end, yet move the computationally heavy tasks of global illumination computation to the cloud. A challenge we face is the interaction delay that causes the frames rendered on the cloud and the client to go out of sync. We propose to use 3D warping and a hole-filling algorithm designed for GI map to predict the late GI map. We show both quantitatively and visually the quality of the GI map produced using our method. Our prediction algorithm allows us to further reduce the frequency at which the GI map is computed and sent from the server, reducing both computational needs and bandwidth usage.
Circulating Tumor Cells Undergoing EMT Provide a Metric for Diagnosis and Prognosis of Patients with Hepatocellular Carcinoma
Authors: Qi Lu-Nan , Xiang Bang-De , Wu Fei-Xiang , Ye Jia-Zhou , Zhong Jian-Hong , Wang Yan-Yan , Chen Yuan-Yuan , Chen Zu-Shun , Ma Liang , Chen Jie , Gong Wen-Feng , Han Ze-Guang , Lu Yan , Shang Jin-Jie , Li Le-Qun
Published: June 2018

To clarify the significance of circulating tumor cells (CTC) undergoing epithelial–mesenchymal transition (EMT) in patients with hepatocellular carcinoma (HCC), we used an advanced CanPatrol CTC-enrichment technique and in situ hybridization to enrich and classify CTC from blood samples. One hundred and one of 112 (90.18%) patients with HCC were CTC positive, even with early-stage disease. CTCs were also detected in 2 of 12 patients with hepatitis B virus (HBV), both of whom had small HCC tumors detected within 5 months. CTC count ≥16 and mesenchymal–CTC (M-CTC) percentage ≥2% prior to resection were significantly associated with early recurrence, multi-intrahepatic recurrence, and lung metastasis. Postoperative CTC monitoring in 10 patients found that most had an increased CTC count and M-CTC percentage before clinically detectable recurrence nodules appeared. Analysis of HCC with high CTC count and high M-CTC percentage identified 67 differentially expressed cancer-related genes involved in cancer-related biological pathways (e.g., cell adhesion and migration, tumor angiogenesis, and apoptosis). One of the identified genes, BCAT1, was significantly upregulated, and knockdown in Hepg2, Hep3B, and Huh7 cells reduced cell proliferation, migration, and invasion while promoting apoptosis. A concomitant increase in epithelial marker expression (EpCAM and E-cadherin) and reduced mesenchymal marker expression (vimentin and Twist) suggest that BCAT1 may trigger the EMT process. Overall, CTCs were highly correlated with HCC characteristics, representing a novel marker for early diagnosis and a prognostic factor for early recurrence. BCAT1 overexpression may induce CTC release by triggering EMT and may be an important biomarker of HCC metastasis.

Significance: In liver cancer, CTC examination may represent an important “liquid biopsy” tool to detect both early disease and recurrent or metastatic disease, providing cues for early intervention or adjuvant therapy. Cancer Res; 78(16); 4731–44. ©2018 AACR.
Clinical Relevance and Suppressive Capacity of Human Myeloid-Derived Suppressor Cell Subsets
Authors: Lang Stephan , Bruderek Kirsten , Kaspar Cordelia , Höing Benedikt , Kanaan Oliver , Dominas Nina , Hussain Timon , Droege Freya , Eyth Christian , Hadaschik Boris , Brandau Sven
Published: June 2018

Purpose: Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of pathologically expanded myeloid cells with immunosuppressive activity. In human disease, three major MDSC subpopulations can be defined as monocytic (M-MDSC), granulocytic [polymorphonuclear-MDSC (PMN-MDSC)], and early stage (e-MDSC), which lacks myeloid lineage markers of the former two subsets. The purpose of this study was to determine and compare the immunosuppressive capacity and clinical relevance of each of these subsets in patients with solid cancer.

Experimental Design: The frequency of MDSC subsets in the peripheral blood was determined by flow cytometry in a cohort of 49 patients with advanced head and neck cancer (HNC) and 22 patients with urological cancers. Sorted and purified MDSC subsets were tested in vitro for their T-cell–suppressive capacity. Frequency of circulating MDSC was correlated with overall survival of patients with HNC.

Results: A high frequency of PMN-MDSC most strongly correlated with poor overall survival in HNC. T-cell–suppressive activity was higher in PMN-MDSC compared with M-MDSC and e-MDSC. A subset of CD66b+/CD11b+/CD16+ mature PMN-MDSC displayed high expression and activity of arginase I, and was superior to the other subsets in suppressing proliferation and cytokine production of T cells in both cancer types. High levels of this CD11b+/CD16+ PMN-MDSC, but not other PMN-MDSC subsets, strongly correlated with adverse outcome in HNC.

Conclusions: A subset of mature CD11b+/CD16+ PMN-MDSC was identified as the MDSC subset with the strongest immunosuppressive activity and the highest clinical relevance. Clin Cancer Res; 24(19); 4834–44. ©2018 AACR.
LncRNA LCPAT1 Mediates Smoking/ Particulate Matter 2.5-Induced Cell Autophagy and Epithelial-Mesenchymal Transition in Lung Cancer Cells via RCC2
Authors: Lin Hongyan , Zhang Xiaohong , Feng Nannan , Wang Ruoyang , Zhang Weituo , Deng Xiaobei , Wang Yu , Yu Xiao , Ye Xiaofei , Li Lei , Qian Ying , Yu Herbert , Qian Biyun
Published: June 2018

Background/Aims: Ecological studies have shown that air pollution and prevalence of cigarette smoking are positively correlated. Evidence also suggests a synergistic effect of cigarette smoking and PM2.5 exposure (Environmental Particulate Matter ≤ 2.5 µm in diameter) on lung cancer risk. We aimed to evaluate the interaction between smoking prevalence and PM2.5 pollution in relation to lung cancer mortality and determine its underlying mechanisms in vitro. Methods: “MOVER” method was used to analyze the interaction between smoking prevalence and PM2.5 pollution in relation to lung cancer mortality. Cell autophagy and malignant behaviors induced by cigarette smoke extract (CSE) and PM2.5 exposure were examined in vitro. Gene expression was examined by qRT-PCR and western blot. RNA and protein interaction was determined using a RNA binding protein immunoprecipitation assay. Results: An increased risk for lung cancer death (RERI (the relative excess risk) =0.28) was observed with a synergistic interaction between cigarette smoking and PM2.5 pollution. Cell migration, invasion, EMT (epithelial-mesenchymal transition) and autophagy were elevated when lung cancer cells were treated with CSE and PM2.5 in combination. A lncRNA, named lung cancer progression-association transcript 1 (LCPAT1), was up-regulated after the treatment of CSE and PM2.5, and knocking down the lncRNA impaired the effect of CSE and PM2.5 on lung cancer cells. In addition, LCPAT1 was shown to bind to RCC2, and RCC2 mediated the effect of LCPAT1 on cell autophagy, migration, invasion and EMT in lung cancer. Conclusions: Our results suggest that combined exposure to CSE and PM2.5 induces LCPAT1 expression, which up-regulates autophagy, and promotes lung cancer progression via RCC2.
Septic Pulmonary Emboli From Peripheral Suppurative Thrombophlebitis: A Case Report and Literature Review
Authors: Ho Vy T. , Rothenberg Kara A. , McFarland Graeme , Tran Kenneth , Aalami Oliver O.
Published: June 2018

Background:

We report the case of a 90-year old woman who presented with septic pulmonary emboli due to suppurative thrombophlebitis at an old peripheral intravenous site.

Methods:

After unsuccessful treatment with antibiotics, the patient was taken to the operating room for excision and drainage of the purulent superficial vein.

Results:

We review the literature and discuss the presentation, risk factors, treatment options, and complications of this often-overlooked disease entity.

Conclusions:

Suppurative thrombophlebitis is a rare but morbid disease that requires a high level of clinical suspicion to diagnose.
Choledochoscopic Examination of a 3-Dimensional Printing Model Using Augmented Reality Techniques: A Preliminary Proof of Concept Study
Authors: Tang Rui , Ma Longfei , Li Ang , Yu Lihan , Rong Zhixia , Zhang Xinjing , Xiang Canhong , Liao Hongen , Dong Jiahong
Published: June 2018

Background. We applied augmented reality (AR) techniques to flexible choledochoscopy examinations. Methods. Enhanced computed tomography data of a patient with intrahepatic and extrahepatic biliary duct dilatation were collected to generate a hollow, 3-dimensional (3D) model of the biliary tree by 3D printing. The 3D printed model was placed in an opaque box. An electromagnetic (EM) sensor was internally installed in the choledochoscope instrument channel for tracking its movements through the passages of the 3D printed model, and an AR navigation platform was built using image overlay display. The porta hepatis was used as the reference marker with rigid image registration. The trajectories of the choledochoscope and the EM sensor were observed and recorded using the operator interface of the choledochoscope. Results. Training choledochoscopy was performed on the 3D printed model. The choledochoscope was guided into the left and right hepatic ducts, the right anterior hepatic duct, the bile ducts of segment 8, the hepatic duct in subsegment 8, the right posterior hepatic duct, and the left and the right bile ducts of the caudate lobe. Although stability in tracking was less than ideal, the virtual choledochoscope images and EM sensor tracking were effective for navigation. Conclusions. AR techniques can be used to assist navigation in choledochoscopy examinations in bile duct models. Further research is needed to determine its benefits in clinical settings.
Novel lumen‐apposing metal stent for the drainage of pancreatic fluid collections: An Italian multicentre experience
Authors: Petrone Maria Chiara , Archibugi Livia , Forti Edoardo , Conigliaro Rita , Di Mitri Roberto , Tarantino Ilaria , Fabbri Carlo , Larghi Alberto , Testoni Sabrina Gloria Giulia , Mutignani Massimiliano , Arcidiacono Paolo Giorgio
Published: June 2018

Background

Endoscopic ultrasound (EUS)‐guided drainage is the procedure of choice for pancreatic fluid collection (PFC) management. Recently developed lumen‐apposing fully covered self‐expandable metal stents (LAMSs) may facilitate drainage, especially of necrotic and complex PFCs.

Objective

To evaluate the feasibility and efficacy of a newly developed LAMS (Nagi, Taiwong Medical Co. Ltd, South Korea) in the drainage of PFCs.

Methods

Retrospective analysis of LAMS drainage of PFCs from seven centres. Patient demographic, EUS and radiological findings, PFCs aetiology, procedural technical and clinical success, and adverse events were evaluated.

Results

Sixty‐seven patients with mean age 58.8 ± 14 years (68.7% males) were included in the analysis. Of these, 44 patients had pseudocyst (PP) and 23 patients had walled‐off pancreatic necrosis (WOPN). Technical success was achieved in 98.5% of cases and clinical success in 94%. The adverse event rate was 24.2%, higher and mostly due to stent migration and occlusion in the WOPN group as compared to the PP group, despite the time to stent removal being significantly lower in the WOPN group.

Conclusions

PFC drainage using the Nagi stent is highly feasible and effective, with a relatively safe profile. Future studies enrolling more patients with complex PFCs are needed to clearly establish the role of this stent in PFC management.
PEOPLE'S BELIEFS IN ANCIENT TIMES AND IT’S EMERGENCE IN THE STYLE OF FOLKLORE
Authors: Йылмаз Мустафа , Yilmaz Mustafa
Published: June 2018

This article deals with the old folk beliefs of the Turkish peoples and the Kyrgyz people in it, and their effects on the emergence of religious poetry. The interaction of fetishist, animist, totemist beliefs in universal religion with Kyrgyz folklore will be analyzed
The Development of Research Skills with the Problems of Real Mathematics in the Elective Course of Pre-Profile Training of Students
Authors: Позднякова Е. , Pozdnyakova E. , Фомина А. , Fomina A.
Published: June 2018

The program of the elective course “Development of research skills in real mathematics” is recommended for the pre-profi le training of the 9th grade students in basic general education. The course does much to promote the formation of mathematical literacy, the development of intellectual skills and mentality qualities typical for mathematical activity and necessary for a person to live in modern society and solve practical problems. The leading type of educational activity of schoolchildren is the project and research activities to solve problems of applied orientation. The article presents the curriculum of the course, its content, types of lessons and forms of control. The forms of training in the organization of research activities of students are defi ned. The project method is recommended as the main learning method.
Classification of Abilities of High School Students in the Geometry Study
Authors: Виситаева М. , Visitaeva Maret
Published: June 2018

The classifi cation of skills, which are the basis of mathematical abilities of students for basic and advanced levels are given: possession of basic techniques common training activities; possession of creative techniques and research training activities; image and the construction of geometrical figures; possession of the basic methods associated with the defi nition of the mutual position, properties and characteristics of geometric shapes and their components; handling trigonometric functions of an acute angle; based on real or mentally (vectors, geometric shapes and geometric quantities).