bluuebunny/crossref_metadata_2025 huggingface dataset:
Scientific-Practical Attitudes of Monitoring Sustainable Development of Pharmaceutical Industry in Russia
Authors: Kazakova Nataliya , Balihin M.
Published: July 2024

The article presents analysis of status and key questions of the development strategy of pharmaceutical industry in Russia. Scientific-practical methods of monitoring were analyzed and critically evaluated. Valuable risk factors of sustainable development of industry were determined. Also, the author’s method, that orientates on transformation of pharmaceutical industry was ordered and principles of monitoring and methods of indicators valuation were developed
Career Guidance for Adolescents with Disabilities in Additional Education for Children
Authors: Shtan'ko I.
Published: July 2024

The article reveals the features of the professional orientation of adolescents with disabilities. The manifestations that must be taken into account when including adolescents in the educational process of additional education are highlighted. The features of the development of elective and propaedeutic courses and an individual educational route for teenagers are outlined.
Technology of the Sport and Practical Orientation of Education (Using the Example of Kyokushinkai Karate Do)
Authors: Ovchinnikov Yu. , Berezhnova S.
Published: July 2024

The authors note the transformation in Russia and the world and the emergence of new directions in the development of sport, associated with national programs and projects, new sports infrastructure. The introduction of new educational standards in sports universities has shown the necessity of developing practice-oriented education for various specialties. The problem of practice-oriented education is considered in several aspects. The technologicity of the sport in the subject technologies of the educational process in the format of the development of practice-oriented education in the University is presented. The base of the research: Technique of a blow in kyokushinkai karate do. Mawashi (from the side, in a circle) geri(leg) jodan (upper level) in a practical lesson on the profile subject “Biomechanics of motor activity”. The methodical map (case) was developed with biomechanical characteristics by phases of movement with the use of specialized terms, video and photo pose-movements with biomechanical characteristics of the athlete.
Experience in Organizing Laboratory Work in Physics As an Example of Practice-Oriented Training
Authors: Fokin Roman
Published: July 2024

The article discusses the application of a practice-oriented approach to the training of cadets studying in the specialty 56.05.01 Logistics in educational organizations of the Federal Penitentiary Service of Russia. The requirements for the training of specialists in the rear services of the penal enforcement system are given. As an example of practice-oriented training, a methodology for organizing laboratory work in physics is proposed. The structure of the academic discipline and the specifics of its implementation in an educational organization are described. The concept of laboratory work, general issues of the organization of laboratory work and methods of their implementation are considered. The description of the methodological support of laboratory classes, the device of the applied laboratory layout, as well as the measuring equipment used is given. The stages of laboratory work, the order of assembly of the experimental installation by students, layouts of tables for entering empirical and calculated data, as well as the preparation of a report on laboratory work are described.
The influence of air pollution on asthma in athletes – a brief review of the literature
Authors: Kruczyk Barbara , Piętak Mateusz , Stradczuk Monika , Mazurek Łukasz , Czach Zuzanna , Bachurska Dominika , Rękas Barbara , Mazurek Wojciech , Olędzka Joanna , Kopacz Wojciech
Published: July 2024

Introduction and purpose 
Air pollution, stemming from natural occurrences and human activities, significantly threatens global health, particularly impacting respiratory conditions like asthma. Air pollution substantially influences asthma exacerbation in athletes, a group particularly vulnerable due to their high physical activity levels and increased respiratory demands. Key pollutants, including particulate matter (PM), ground-level ozone (O3), sulfur dioxide (SO2), and nitrogen dioxide (NO2), play critical roles in asthma development and exacerbation.
The State of Knowledge
Asthma, a chronic inflammatory disease influenced by genetic predisposition and environmental factors like air pollution, is characterized by airway hyperresponsiveness, obstruction, and chronic inflammation, leading to symptoms such as shortness of breath, coughing, wheezing, and chest tightness. Research highlights the link between air pollution exposure and asthma development, with PM2.5 exposure associated with increased asthma risk and pollutants exacerbating symptoms, especially in children. Athletes inhaling air pollutants during exercise face increased airway inflammation, mucus production, and bronchospasm, worsening asthma symptoms like wheezing and shortness of breath.  Chronic exposure decreases lung function, increasing reliance on medication and limiting outdoor training on polluted days.
Summary
Effective asthma management amidst air pollution requires personal, community, and governmental measures. Patients should minimize exposure by wearing N95 masks and choosing low-traffic routes. Governments must monitor pollution, inform the public, and control emissions through alternative fuels and technologies. Adhering to WHO air quality guidelines could prevent many new asthma cases, emphasizing comprehensive air quality management's importance, especially among vulnerable populations like children.
CEO Humility and Corporate Social Irresponsibility: Evidence Based on a New Unobtrusive Measure
Authors: Ou Amy Y. , Lu Qian , Li Xina , Chi-Nien Chung , Chen Guoli
Published: August 2024

Chief executive officers (CEOs) are expected to guard their firms against corporate social irresponsibility (CSIR) incidents. In this study, we hypothesize that CEO humility relates negatively to CSIR occurrence and positively to correction because of CEO preferences for protecting stakeholder interests and employing systematic information processing. These associations are stronger in industries with a high number of CSIR incidents and when top management teams have a higher ratio of gender and racial minorities. We develop and validate a new unobtrusive measure of CEO humility by using automated, objective behavioral indicators derived from earnings conference call transcripts. Our arguments and hypotheses are mostly supported by a sample of 197 Fortune 500 firms, 275 CEOs, and 1,243 firm-year observations from 2002 to 2015. Our study contributes to a more complete understanding of CEOs’ role in CSIR prevention and correction, widens the scope of CEO humility research by including stakeholder-centered firm outcomes, and mitigates measurement constraints in understanding CEO humility-firm action relationships.

Funding: This work was supported by Hong Kong Polytechnic University [Grant P0030113] and the National Science Foundation of China [Grants 71602086, 71632005, 72372068, and 72072088], and INSEAD [Ian Potter (‘93D) PhD Award].

Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2022.17104 .
Çocuklar İçin Felsefe ile İlgili Akademik Yayınların Bibliyometrik Haritalama Analizi
Authors: Kahraman Emine , Ağaya Ayşıl , Akgül Savaş
Published: July 2024

Çocuklar için Felsefe (Philosophy for Children-P4C) Lipman tarafından 1960’lı yıllarda oluşturulan çocukların daha bağımsız düşünmelerini sağlayan, karşılıklı öğretmen-öğrenci diyaloğunu ve çocukların soru sormalarının teşvik edildiği, öğretmenin açık uçlu sokratik sorgulama yöntemini kullandığı bir süreçtir. Bu çalışmanın amacı, P4C ile ilgili eğitim alanında yayımlanan akademik yayınların bibliyometrik haritalama analizine göre incelemektir. Bu amaç doğrultusunda, Web of Science veri tabanında P4C kavramı üzerine yayımlanan eğitim alanında akademik yayınların günümüze kadar olan süreçteki genel eğilimi incelenmiştir. Araştırmada elde edilen verilerin analiz edilerek görselleştirilmesinde VOSviewer kullanılmıştır. Araştırmanın sonucuna göre; P4C ile ilgili en fazla akademik yayının 2017 yılında ABD’de gerçekleştirildiği görülmüştür. Araştırma kapsamında çok disiplinli bir yapıya sahip olan P4C kavramının eğitim araştırmalarıyla sınırlandırıldığında en çok felsefe, sosyal bilimler tarihi, disiplinlerarası sosyal bilimler, dil bilimi, gelişimsel psikoloji ve eğitsel psikoloji konu alanlarında çalışıldığı belirlenmiştir. Ayrıca farklı alanlardan fen eğitimi, öğretmen eğitimi, okul liderliği, eleştirel düşünme ve iş etiği, öz-düzenlemeli öğrenme, ebeveynlik, din eğitimi ve fonolojik farkındalık kavramlarıyla da ilişki içerisindedir.
Ergenlerde Koronavirüs Fobisi, Belirsizliğe Tahammülsüzlük ve Öznel İyi Oluş: Koronavirüse Yakalanma ve Yakınını Kaybetme Durumlarına İlişkin Düzenleyici-Aracı Modellerin Sınanması
Authors: Ülker Müjgan , Soysal Sümeyra , Bilge Filiz
Published: July 2024

Koronavirüs fobisi; bireylerin koronavirüse yakalanma, hastalanma, hastalığın ağır seyretmesi korkusudur. Belirsizliğe tahammülsüzlük bireylerin sonu belli olmayan bir olaya karşı sabırsızlık derecesidir. Öznel iyi oluş, bireylerin olumlu duygulanımın olumsuz duygulanımdan daha fazla olduğunu hissettiği durumudur. Bu araştırmanın amacı ergenlerin koronavirüs fobisi ve belirsizliğe tahammülsüzlük arasındaki ilişkide öznel iyi oluşun aracı etkisi ile koronavirüse yakalanma ve koronavirüsten dolayı yakınını kaybetme durumlarının düzenleyici etkilerini incelemektir. Araştırmanın katılımcılarını, 2021-2022 eğitim-öğretim yılında öğrenim gören ve yaşları 15 ile 17 arasında değişen toplam 1011 lise öğrencisi (504 kadın, 507 erkek) oluşturmuştur. Veriler kişisel bilgi formunun yanı sıra “Koronavirüs Fobisi Ölçeği”, “Belirsizliğe Tahammülsüzlük Ölçeği”, “Ergen Öznel İyi Oluş Ölçeği” ile toplanmıştır. Araştırma sonucunda ergenlerin koronavirüs fobisi ve belirsizliğe tahammülsüzlük arasındaki ilişkide öznel iyi oluşun aracı etkisinin olduğu belirlenmiştir. Bu iki değişkende öznel iyi oluş aracı etkisi altında koronavirüse yakalanma durumunun düzenleyici etkisi bulunmazken; koronavirüsten dolayı yakınını kaybetme durumunun düzenleyici etkisi olduğu saptanmıştır. Buna göre ergenler koronavirüsün kendilerine bulaşmasından ziyade virüsten dolayı yakınlarını kaybetme korkusu yaşıyor olabilir.
A rapid and easy-to-use spinal muscular atrophy screening tool based on primers with high specificity and amplification efficiency for SMN1 combined with single-stranded tag hybridization assay
Authors: Hirano Masaki , Sahashi Kentaro , Ichikawa Yuki , Katsuno Masahisa , Natsume Atsushi
Published: August 2024

Spinal muscular atrophy (SMA) is an intractable neuromuscular disorder primarily caused by homozygous deletions in exon 7 of theSMN1gene. Early diagnosis and prompt treatment of patients with SMA have a significant impact on prognosis, and several therapies have recently been developed. Current SMA screening tests require a significant turnaround time to identify patients with suspected SMA, due both to the interval between the birth of a newborn and the collection of blood for newborn mass screening and the difficulty in distinguishing betweenSMN1andSMN2, a paralog gene that requires testing in specialized laboratories. The aim of this study was therefore to develop a novel SMA screening assay that can be rapidly performed in ordinary hospitals and clinics to overcome these issues. We designed over 100 combinations of forward and reverse primers with 3′ ends targetingSMN1-specific sites around exon 7, and evaluated their specificity and amplification efficiency by quantitative PCR to identify the best primer pair. Furthermore, we performed a single-stranded tag hybridization assay after PCR. To evaluate the accuracy and practicality of the newly developed assay, we analyzed saliva specimens from five patients with SMA and two SMA carriers collected in an outpatient clinic and DNA specimens from three patients with SMA and four SMA carriers from a biobank, together with those from healthy individuals. DNA and raw saliva specimens from all patients with SMA demonstrated a biallelic loss ofSMN1, whereas those from carriers and healthy individuals did not. The results of 50 independent experiments were consistent for all samples. The assay could be completed within one hour. This simple and convenient new screening tool has the potential to allow patients with SMA to receive disease-modifying therapies within a shorter timeframe.
Enolase inhibitors as therapeutic leads for Naegleria fowleri infection
Authors: Milanes Jillian E. , Yan Victoria C. , Pham Cong-Dat , Muller Florian , Kwain Samuel , Rees Kerrick C. , Dominy Brian N. , Whitehead Daniel C. , Millward Steven W. , Bolejack Madison , Shek Roger , Tillery Logan , Phan Isabelle Q. , Staker Bart , Moseman E. Ashley , Zhang Xiang , Ma Xipeng , Jebet Audriy , Yin Xinmin , Morris James C.
Published: August 2024

Infections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amoebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking and the mortality rate remains >95% in the US. Glycolysis is very important for the infectious trophozoite lifecycle stage and inhibitors of glucose metabolism have been found to be toxic to the pathogen. Recently, human enolase 2 (ENO2) phosphonate inhibitors have been developed as lead agents to treat glioblastoma multiforme (GBM). These compounds, which cure GBM in a rodent model, are well-tolerated in mammals because enolase 1 (ENO1) is the predominant isoform used systemically. Here, we describe findings that demonstrate these agents are potent inhibitors of N. fowleri ENO (NfENO) and are lethal to amoebae. In particular, (1-hydroxy-2-oxopiperidin-3-yl) phosphonic acid (HEX) was a potent enzyme inhibitor (IC50 = 0.14 ± 0.04 μM) that was toxic to trophozoites (EC50 = 0.21 ± 0.02 μM) while the reported CC50 was >300 μM. Molecular docking simulation revealed that HEX binds strongly to the active site of NfENO with a binding affinity of –8.6 kcal/mol. Metabolomic studies of parasites treated with HEX revealed a 4.5 to 78-fold accumulation of glycolytic intermediates upstream of NfENO. Last, nasal instillation of HEX increased longevity of amoebae-infected rodents. Two days after infection, animals were treated for 10 days with 3 mg/kg HEX, followed by one week of observation. At the end of the one-week observation, eight of 12 HEX-treated animals remained alive (resulting in an indeterminable median survival time) while one of 12 vehicle-treated rodents remained, yielding a median survival time of 10.9 days. However, intranasal HEX delivery was not curative as brains of six of the eight survivors were positive for amoebae. These findings suggest that HEX requires further evaluation to develop as a lead for treatment of PAM.
Análise das questões da prova de III nível da Olimpíada Brasileira de Astronomia e Astronáutica:
Authors: Bartelmebs Roberta , Milena Tegon Figueira Maria , Iachel Gustavo
Published: July 2024

Este artigo é um recorte de uma pesquisa de mestrado, cujo objetivo foi verificar se as questões das provas do III nível da OBA estão adequadas a capacidade cognitiva de seus participantes. Categorizamos as questões de 2012 a 2022, de acordo com os conteúdos e as competências cognitivas exigidas nas questões, a partir do viés teórico da epistemologia genética. A escolha da prova do nível III se deve ao fato de abarcar crianças e adolescentes com idade e escolaridade de níveis diferentes (11 a 14 anos, 6° ao 9°ano, respectivamente). Essa pesquisa é de cunho misto (qualitativa e quantitativa) e a análise dos dados foi realizada por meio da Análise de Conteúdo de Bardin (2016). A análise pautou-se no estudo dos estádios de desenvolvimento cognitivo desenvolvidos por Piaget e colaboradores. As questões foram classificadas em estádio operatório concreto I, II e operatório formal. Das 157 questões investigadas, 62 foram classificadas no nível formal. Esse número é significativo, considerando que somente a partir dos 12 anos em média o indivíduo entra no estádio operatório formal, ou seja, 39% das questõesprovavelmente não serão resolvidas com êxito por alunos do operatório concreto.
Viagem à Lua:
Authors: Rodrigues João Henrique , Oliveira Joyce Machado
Published: July 2024

A viagem à Lua recobrou o seu destaque nas mídias sociais e nos meios de comunicação nos últimos anos graças aos avanços da empresa SpaceX. Em busca de uma forma de conectar os tópicos de Astronomia ensinados na Base Nacional Comum Curricular no Brasil e a realidade científica atual, e contribuir para a divulgação científica, o presente trabalho visa adaptar a Física envolvida em voos espaciais, permitindo uma abordagem mais viável em salas de aula do Ensino Médio. Inicialmente, utilizou-se a viagem à Lua e os conceitos de Movimento Retilíneo e Circular Uniforme, bem como a Lei da Gravitação Universal, para analisar a aceleração que ocorre no foguete ao longo da viagem Terra-Lua e analisou a quantidade aproximada de energia necessária para atingir a Lua. Investigou-se os pontos de lançamento que permitiriam a economia de energia e, consequentemente, de combustível. Foram utilizados os conceitos de variação de posição angular para calcular os pontos de partida e chegada do foguete durante a viagem Terra-Marte. Por fim, foram investigados os desafios técnicos e logísticos envolvidos na viagem a Marte, bem como o uso de simulações para abordar questões mais abstratas.
A perspectiva dos professores dos Anos Iniciais acerca do uso e da criação de jogos analógicos no Ensino de Astronomia
Authors: Da Silva Oliveira Vanessa Simões , Florczak Marcos Antonio , Chiesa Bartelmebs Roberta
Published: July 2024

Este estudo tem como objetivo analisar a perspectiva dos professores dos anos iniciais do Ensino Fundamental em relação ao uso e à criação de jogos para o ensino da Astronomia. Para isso, foi conduzida uma pesquisa com professores da rede municipal de Curitiba que lecionam Ciências ou em áreas afins, como Ciência e Tecnologias (prática da Educação Integral) e Farol do Saber Inovação (Laboratório Maker), por meio de um questionário online aplicado pelo Google Forms. Um total de 43 questionários foram respondidos, fornecendo dados sobre a eficácia dos jogos analógicos no ensino de Astronomia, bem como as discussões sobre suas potencialidades e desafios. A partir da análise de conteúdo, concluímos que tanto o uso quanto a criação de jogos são recursos promissores para o ensino da Astronomia, pois permitem a exploração de conceitos astronômicos em sala de aula e incentivam os professores a buscar conhecimentos específicos nessa área. No entanto, os participantes identificaram alguns desafios, destacando a necessidade de mais formação e materiais de apoio específicos para a implementação eficaz dos jogos no contexto educacional.
Um jogo digital que apresenta a origem dos elementos químicos
Authors: Siqueira Crediana , Oliveira Adhimar , Figueiredo Newton , Silva Milady , Faria Marcos
Published: July 2024

A pandemia da covid-19 provocou mudanças no comportamento das pessoas em ambientes compartilhados que afetaram também o ambiente escolar. Muitos professores tiveram que modificar suas aulas para se adaptar ao ensino remoto e superar as dificuldades impostas pelo distanciamento social. O uso de tecnologias digitais de informação e comunicação e de metodologias ativas tornou-se uma das melhores formas de superar alguns dos desafios impostos ao ensino nesse período. Este trabalho apresenta o desenvolvimento do jogo digital “A tabela periódica segundo a cosmoquímica”, bem como a aplicação e avaliação da versão inicial com estudantes do ensino médio. O principal objetivo do jogo é apresentar a origem dos elementos químicos dentro do contexto da astronomia. O jogo pode facilitar a compreensão da tabela periódica, sua importância no cotidiano e como ocorreua evolução do Universo primordial, a depender dos objetivos de aprendizagem, do contexto da sala de aula e da disciplina na qual ele for utilizado. Alguns elementos do jogo que o caracterizam como jogo educativo foram avaliados em uma turma piloto e os resultados foram positivos. Observou-se uma boa interação e aceitação dos estudantes pelo jogo e uma melhora nas respostas após o contato com o jogo.
Resenha da tese de doutorado de Juan Barrio:
Authors: Sobreira Paulo Henrique Azevedo
Published: July 2024

Resenha sobre a tese de doutorado de Juan Bernardino Marques Barrio, pela Universidad de Valladolid, defendida em 2003, que trata do uso do Planetário como um recurso didático para o ensino da Astronomia, e que ainda é uma temática pouco explorada no meio da Educação em Astronomia.
Preservation of urine specimens for metabolic evaluation of recurrent urinary stone formers
Authors: Šálek Tomáš , Musil Pavel , Vermeersch Pieter , Marrington Rachel , Dikmen Zeliha G. , Poláchová Radka , Kipman Ulrike , Kouri Timo T. , Cadamuro Janne
Published: July 2024

Objectives

Stability of concentrations of urinary stone-related metabolites was analyzed from samples of recurrent urinary stone formers to assess necessity and effectiveness of urine acidification during collection and storage.

Methods

First-morning urine was collected from 20 adult calcium-stone forming patients at Tomas Bata Hospital in the Czech Republic. Urine samples were analyzed for calcium, magnesium, inorganic phosphate, uric acid, sodium, potassium, chloride, citrate, oxalate, and urine particles. The single-voided specimens were collected without acidification, after which they were divided into three groups for storage: samples without acidification (“NON”), acidification before storage (“PRE”), or acidification after storage (“POST”). The analyses were conducted on the day of arrival (day 0, “baseline”), or after storage for 2 or 7 days at room temperature. The maximum permissible difference (MPD) was defined as ±20 % from the baseline.

Results

The urine concentrations of all stone-related metabolites remained within the 20 % MPD limits in NON and POST samples after 2 days, except for calcium in NON sample of one patient, and oxalate of three patients and citrate of one patient in POST samples. In PRE samples, stability failed in urine samples for oxalate of three patients, and for uric acid of four patients after 2 days. Failures in stability often correlated with high baseline concentrations of those metabolites in urine.

Conclusions

Detailed procedures are needed to collect urine specimens for analysis of urinary stone-related metabolites, considering both patient safety and stability of those metabolites. We recommend specific preservation steps.
Anti-cancer effects of hyperbaric oxygen therapy in mice: a meta-analysis
Authors: Klement Rainer Johannes , Eckert Jan Mathis , Sweeney Reinhart A.
Published: August 2024

Objectives

Hypoxia is a ubiquitous condition in solid tumors and is associated with increased glycolysis, therapy resistance and disease progression. Hyperbaric oxygen therapy (HBOT) systemically elevates O2 tension in tissues and thus counteracts hypoxia. Here, we conducted a meta-analysis to quantify the effects of HBOT on survival in mice with cancer.

Methods

Studies retrieved from PubMed and Google Scholar were included if they allowed extracting restricted mean survival times in an HBOT-treated and control group. Meta-analyses were conducted using standardized mean differences (SMDs) and the log-transformed response ratio (lnRR) between the RMST of the treatment and control group with multilevel random effects models in order to account for non-independence of effect sizes. Publication bias was tested using a multilevel version of Egger’s regression.

Results

All studies applied HBOT with pressures between 2 and 3 atmospheres absolute (ATA). When administered without additional treatments, HBOT was associated with longer mouse survival times (pooled SMD=1.359 ± 0.624, p=0.0446; lnRR=0.065 ± 0.029, p=0.0399). Higher pressure was significantly associated with higher efficacy of hyperbaric oxygen monotherapy. When combined with chemotherapy, radiotherapy, targeted therapy or a ketogenic diet, HBOT was associated with significantly prolonged survival times compared to mice receiving these treatments without HBOT (SMD=2.696 ± 0.545, p<0.0001; lnRR=0.228 ± 0.042, p<0.0001). The combination of HBOT with chemotherapy was associated with lower efficacy than the combination with other treatment modalities.

Conclusions

We found weak evidence that HBOT prolongs survival times in cancer-bearing mice and strong evidence for synergistic effects with other therapies. The translational potential of these findings and extrapolation to lower-pressure HBOT remain to be determined.
“Goodbye, I Love You”: Fyodor Dostoevsky in the Farewell Notes of Anna Dostoevskaya in 1881
Authors: Andrianova Irina , Tikhomirov Boris
Published: July 2024

The notebook of Fyodor Dostoevsky’s widow for the fatal 1881 is the most sought-after by the writer’s biographers. It contains the notes made by Anna Dostoevskaya for herself about her late husband within a few months after his death, according to the most recent memories of him. On paper, using shorthand signs in some cases, she recorded joint purchases, gifts received from her husband, his characteristic words, habits, tastes, manner of bearing, dressing, reciting aloud, peculiarities of eating, conversation, creative work (including the January issue of “A Writer’s Diary,” published after Dostoevsky’s death), recorded information related to the writer’s childhood years spent in Moscow, as well as the last days and hours of his life, the details of the funeral and funeral service, the children’s memories of their father. These recordings have already been published, but not in full and in violation of the sequence. Despite their fragmentary nature, unformulated into processed memories, and chaotic arrangement, they have their own composition and logic. The memoirist structures the farewell text with a dear person who continues to live in her memory in a specific way: she opens the entries with sketches of the writer’s plans for the next 10 years, and concludes with a dialogue about children as successors of the Dostoevsky family. Memories of the writer are not the only materials in the composition of Anna Dostoevskaya’s notebook. It also includes other documents of historical and literary value (bills, receipts, receipts, address records, letters, a newspaper clipping with an obituary about Doctor of Medicine Ivan Verevkin, etc.), a comprehensive review of which is presented for the first time in this article. In the course of the study, corrections were made to the previously transcribed text of Anna Dostoevskaya’s transcripts (by the Leningrad stenographer Ceciliia Poshemanskaya), errors in the manuscript rendition made in previous publications of this document were corrected. In the Appendix to the article, memoirs from Anna Dostoevskaya’s notebook of 1881 are published in full, accompanied by historical and literary commentaries based on the latest achievements of the study of Dostoevsky’s work.
Dostoevsky in the Plain Language: The Problems of Modern Literary Translation
Authors: Borisova Valentina , Kosmarskaia Iskra
Published: July 2024

The article is devoted to the functional analysis of one of the modern adaptive models of the national literary language — the plain language. This concept is actively discussed and implemented in modern translation practice today, including in numerous literary translations of the works of Dostoevsky, the most widely read Russian writer in the world. From a historical and typological point of view, the new translation strategy correlates with the principles of the Russian translation of the first book from Dostoevsky’s reading circle — “One Hundred and Four Sacred Stories of the Old and New Testaments,” as well as the New Testament published in 1823, which includes the writer’s hard labor Gospel that became a key precedent text in his post-reformation work. The article analyzes the work performed in the early 2000s. Japanese scientist Ikuo Kameyama translated the novel “The Brothers Karamazov,” which was a representative experience of modern artistic interpretation and adaptation of Dostoevsky’s work. Thanks to the translator’s orientation to the plain language, the novel of the Russian writer found its foreignspeaking readers and became an understandable and familiar text for them.
“…She’s a Sweet Sister and a Wonderful Person:” Varvara Mikhailovna Dostoevskaya-Karepina and Her Family (Additions to “The Chronicle of the Generations of Dostoevskys”)
Authors: Drobyshevskaya Inga , Tikhomirov Boris
Published: July 2024

The article introduces the results of archival research devoted to the family of the eldest of F. M. Dostoevsky’s sisters, V. M. Karepina. Vital records (records of birth, wedding, death) of Varvara Mikhailovna herself, her husband Pyotr Andreevich Karepin, their children and grandchildren, discovered by the authors of the article in the funds of the Central State Archive of the City of Moscow (CSA of Moscow), are published. The materials of the archival “Case of the Moscow Noble Deputy Assembly” are introduced into scientific circulation, including documents related to the inclusion in the 3rd part of the Genealogical Book of the Moscow Province of Dostoevsky’s sister’s husband, P. A. Karepin (1838) and the family of their son, the eldest nephew of the writer A. P. Karepin (1911). The documents in this case include the form list of P. A. Karepin, the decree on the resignation of A. P. Karepin, copies of metric documents on the wedding and death of Dostoevsky’s nephew, and the birth of his son, Vladimir Karepin. The published archival materials fill in significant factual gaps in the pedigree of the genealogical branch of Varvara Mikhailovna Dostoevskaya-Karepina, which was published in the fundamental “Chronicle of the Generations of Dostoevskys” (2012), which was a revised and supplemented republication of the classic work of M. V. Volotsky “The Chronicle of the Generations of Dostoevsky” (1933). The Appendix contains two biographical notes: about the daughter of P. A. Karepin from his first marriage, stepdaughter of V. M. Dostoevskaya-Karepina — Yulia Petrovna Pomerantseva and her husband Nikandr Petrovich Pomerantsev.
Dostoevsky in a Free Application: the Publishing Project of Adolf Marx in the Notebooks of Anna Dostoevskaya
Authors: Stepchenkova Valentina
Published: July 2024

The publication of the Complete Works of F. M. Dostoevsky became the main deed of his widow. Over the course of 10 years, book publication has been stable and profitable for the writer’s family. In 1893, the publisher of the weekly “Niva,” A. F. Marx, offered Anna Grigoryevna to sell him the literary rights to Dostoevsky’s works for printing them as a free supplement to his magazine. Dostoevskaya devoted a chapter of published memoirs to this transaction, but her unpublished notebooks contain additional information about both the external side of the agreement with Marx (lists, dates, notes) and the inner world of the publisher during this period (memories, experiences, doubts, comments). This article introduces into scientific circulation the materials of A. G. Dostoevskaya’s notebooks about family meetings about the sale of literary rights, details and curious stories related to the signing of an agreement with Marx. Ultimately, the deal with Marx was not as profitable as it seemed at first. It divided the publishing activities of the writer’s widow into “before” and “after” the contract: the time after the return of copyright was marked by a sharp decline in demand for Dostoevsky’s works due to the surplus of the Complete works of the Marx publishing house on the book market. The contract with “Niva’s” publisher turned out to be one of the essential circumstances in the process of termination of A. G. Dostoevskaya’s publishing activities in 1910. Despite the adverse consequences of the deal with Marx for the Dostoevsky family's book business, the writer’s widow remained friendly with “Niva’s” publisher, as evidenced by the documents provided in the article: her letter to him about the donation and publication of three letters from Dostoevsky to his brother Mikhail, as well as the mentions of the name of Marx and his publications in notebooks.
Dostoevsky’s Great Pentateuch: Concept, Translation, Interpretation
Authors: Zakharov Vladimir
Published: July 2024

Dostoevsky has been successfully translated into different languages. He remains himself even in unsuccessful translations. Every translation is an interpretation. Interpretations include not only critical publications, but also theatrical productions and screen adaptations. Translations and interpretations expand the corpus of Dostoevsky’s texts. Translation is universal. Dostoevsky is in demand for translations not only into foreign languages, but also from Russian into Russian: manuscript to printed text, printed text to multimedia format. Over the last hundred years, the graphics, orthography and punctuation of the Russian language have changed. Changes in the language distort the meaning of Dostoevsky’s works. Both the shortcomings and the achievements of Soviet and post-Soviet textology are most fully presented in the Complete Works of Dostoevsky. They resulted in the amended texts of the writer, which, in turn, required new translations into foreign languages. The concept of “Dostoevsky’s Pentateuch” is tentative. Had Dostoevsky lived longer, he may have written more great novels: not five, but six or more. And now “Poor People,” “Notes from the Dead House,” “Notes from Underground,” “Diary of a Writer” are added to Dostoevsky’s five great novels . Of the different Pentateuchs, there are two personal ones: one by Moses, the other by Dostoevsky, which was immediately labeled “great.” The concept of the “great Pentateuch” has many authors. It became common place in conference debates as early as the 1970s. At first, it was a rhetorical figure that stated the number of Dostoevsky’s famous novels. At present it is a concept that expresses the ideological content, genre and poetics of the writer’s late novels.
“...From Some Klepiki”: Dostoevsky's Russia in Letters and Documents
Authors: Sosnovskaya Oksana , Andrianova Irina
Published: July 2024

The reason for writing this article was a letter received by the authors from the founders of the recently established local history museum in Spas-Klepiki, Ryazan region. This small town is actively working on the formation of museum funds and collections. S. A. Esenin, A. I. Kuprin, K. G. Paustovsky lived and visited here. According to the organizers, the history of the Dostoevsky family at the turn of the XX century should take a worthy place in one of the expositions. The article systematizes published and unknown archival materials about its stay in Spas-Klepiki and surrounding villages. The lands, forest and estate located here was inherited by F. M. Dostoevsky and his relatives after the death of his rich Moscow aunt A. F. Kumanina. The writer learned about the existence of Klepiki on August 19, 1879 from a letter to him from his wife, who visited the Ryazan region with their children. However, protracted litigation over the division of inheritance did not allow Dostoevsky to become a landowner legally, he did not have time to visit this land. On March 24, 1881 his widow and children were confirmed in the rights of inheritance. According to family correspondence, A. G. Dostoevskaya, accompanied by her son Fyodor, visited Spas-Klepiki in the 1880s and 1890s and stayed at the house of lawyer A. D. Povalishin. She described her way from Ryazan to the estate in her notebook of 1881, and here she also indicated the names of residents of Klepiki who could be useful to her. The writer's widow bought out the share of the estate in the Ryazan province, which was inherited by her husband's younger brother A. M. Dostoevsky. She sold part of her lands in 1895, and returned to the sale issue in 1905 at the request of her son Fyodor. Dostoevsky's son became a Ryazan nobleman in 1897, but he did not live in Ryazan permanently. The life of the Sher family, Dostoevsky's maternal relatives and co-owners of the "Kumaninsky inheritance", is connected with Spas-Klepiki. The search for Dostoevsky's documents in the Ryazan archives is relevant. Their discovery would help to reveal new facts of the writer's family’s stay in the Ryazan region and Spas-Klepiki, to expand the funds of the city’s local history museum, which needs Dostoevsky.
Optimal variable acceptance sampling plan for exponential distribution using Bayesian estimate under Type-I hybrid censoring
Authors: Marıa Mathaı Ashlyn , Kumar Mahesh
Published: July 2024

Acceptance sampling plans with censoring schemes are crucial for improving quality control by efficiently managing incomplete information. This approach improves cost and time effectiveness compared to traditional methods, providing a more accurate assessment of product quality. In this study, a variable acceptance sampling plan under Type-I hybrid censoring is designed for a lot of independent and identical units with exponential lifetimes using Bayesian estimation of the mean life. This novel approach diverges from conventional methods in acceptance sampling plans, which rely on maximum likelihood estimation and the minimization of Bayes risk. Bayesian estimation is obtained using both squared error loss and Linex loss functions. Under each method, a nonlinear optimization problem is solved to minimize the testing cost, and the optimal values of the plan parameters are determined. The proposed plans are illustrated using various numerical examples, with each plan presented in tables. The acceptance sampling plan using the squared error loss function proves to be more cost-effective than the plan using the Linex loss function. A comparative analysis of the proposed plans with existing work in the literature demonstrates that our cost is much lower than the cost of existing plans using maximum likelihood estimation. Additionally, a real-life case study is conducted to validate the approach.
Algorithm for assessing the level of T cell immune response against SARS-CoV-2 and the results of its application in unvaccinated and vaccinated people who have been infected with COVID-19
Authors: Blyakher M. S. , Fedorova Irina M. , Koteleva S. I. , Kapustin I. V. , Tulskaya E. A. , Ramazanova Z. K. , Odintsov E. E. , Sandalova S. V. , Novikova L. I. , Bochkareva S. S.
Published: July 2024

Antigen (AG)-specific T cell activity was compared in two groups of patients: those who underwent COVID-19 in 2021 during the circulation of the SARS-CoV-2 delta virus strain (43 individuals); and those who underwent COVID-19 in 2022 (Omicron strain, 23 individuals). The diagnosis was confirmed by PCR analysis of nasopharyngeal and oropharyngeal swabs. The 23 individuals following COVID-19 caused by SARS-CoV-2 (omicron) were part of a cohort of 41 volunteers who were examined multiple times during 2021–2023: during vaccination, after vaccination, before revaccination, and subsequently after illness (6–8 times in total). Due to this, it was possible to compare the indices of specific humoral and cellular immunity in the same patients 1–2 months before and after breakthrough infection. Detection of AG-specific T cells and assessment of their activity by AG-stimulated IFNγ production was carried out by our own previously developed method (Patent RU № 2780369 C1). For stimulation of memory T effectors in vitro, the same antigens were used to determine the concentration of antibodies against SARS-CoV-2 by ELISA method. A total of about 300 blood samples from healthy subjects and patients after COVID-19 were analyzed. Each sample was tested against 3 SARS-CoV-2 antigens and in 2 stimulation modes. A qualitative assessment algorithm for AG-specific T cell activity has been proposed that can be used to monitor the state of cellular immunity in a population in which SARS-CoV-2 virus continues to circulate and to create insights into what level of T cell activation is sufficient to prevent or reduce the severity of SARS-CoV-2 infection. Unvaccinated COVID-19 (SARS-CoV-2, Delta) survivors lacked AG-specific T cells to RBD SARS-CoV-2, but T cell specificity to full-length S glycoprotein at the same level, qualitatively assessed as low in 52% of the group, persisted for up to six months. In previously unvaccinated COVID-19 vaccinees, this duration of persistence of AG-specific T cells in circulating blood was achieved only after revaccination. Hybrid immunity, which we traced as a result of vaccination after COVID-19 (Delta strain) or as a breakthrough infection (SARS-CoV-2, Omicron), is characterized by the highest indices of memory T cell activity (43–46% of the group — normal activity of AG-specific cells, 30–43% — high activity) to all used antigens and the longest duration of preservation of indices at this level. Further investigation of the level of antiviral immunity after COVID-19 may be important for predicting the outcome of new waves of SARS-CoV-2 infection.
Blood cytokines as potential predictors of the development of SARS-CoV-2 associated pneumonia in patients with stage II ESSENTIAL hypertension
Authors: Radaeva Olga A. , Simbirtsev A. S. , Iskandyarova M. S. , Negodnova E. V. , Kulyapkin V. V. , Krasnoglazova K. A. , Eremeev V. V.
Published: July 2024

The search for predictors of the severe course of COVID-19 was relevant both during the pandemic and at the present time. The aim of the study was to analyze the relationship of cytokine levels in patients with EН before SARS-CoV-2 infection with the incidence of coronavirus pneumonia. Materials and methods. From the database of 290 patients with stage II EAG who have been under observation for 8–12 years with annual blood sampling to determine cytokine levels, COVID-19 survivors were selected (mild without pneumonia and moderate to severe, pneumonia CT 1–2, CT-3). Anamnestic levels of IL-1β, IL-1α, IL-1ra, IL-18, IL-18 BP, IL-37, IL-6, sIL-6r, M-CSF, VEGF-A, IL-34 and HMGB1) in the blood serum of patients with stage II EH were analyzed (method ELISA). The analysis of the obtained results was carried out using Stat Soft Statistica 13.5. Results and discussion. Patients with EH and COVID-19 with pneumonia (CT I-II) after SARS-CoV-2 infection 2–6 months before the infectious disease had significantly higher serum levels: IL-1α (p 0.05) and a decrease in IL-37 (p 0.001). During multivariate correlation analysis, a statistically independent relationship between an increase in the incidence of viral pneumonia in patients with stage II EН was confirmed only for IL-37 with a blood level of less than 60.2 pg/ml (regression coefficient — 2.21, standard error — 0.28, t criterion — 6.12, relative risk — 2.52, criterion Walda — 7.92, p = 0.006). When studying circadian rhythms of cytokine content in blood serum in patients of the analyzed groups, calculating the strength of correlations of anamnestic evening IL-37 levels in patients with stage II EР at 19.00–20.00 with the frequency of pneumonia against the background of SARS-CoV-2 infection, it has greater specificity and sensitivity (specificity — 0.75, sensitivity — 0.82) than morning concentrations. Considering that data on circadian rhythms were obtained in a limited number of patients, further monitoring is necessary, which is carried out by our scientific group. It should be noted that patients with essential hypertension are pathogenetically heterogeneous, including in terms of cytokine regulation. The study of this area will make it possible to personalize cytokine phenotypes of the disease and develop new methods for calculating the prognosis of both cardiovascular complications and features of the course of infectious diseases.
Broncho-obstructive syndrome and the enzymes of cellular energy metabolism after coronavirus infection
Authors: Kosyakova Ninel I. , Akulenko M. V.
Published: July 2024

Broncho-obstructive syndrome (BOS) after coronavirus infection is characterized by long-term, dry and painful cough which is hard for treatment, significantly reducing the quality of life of the patients. The goal of the study: to investigate the specific features of clinical manifestations of BOS diagnosed for the first time in patients belonging to different age groups in post-COVID-19 period and to estimate the degree of mitochondrial dysfunction by the imbalance of the enzymes of cellular energy metabolism. Materials and methods. 298 patients with BOS (age 18–78) were observed continuously for 2 years. Standard clinical, biochemical and functional examination was carried out, Saint George`s Respiratory Questionnaire (SGRQ) was used. Mitochondrial dysfunction was determined by the ratio of levels of two enzymes, lactate dehydrogenase (LDH) and succinate dehydrogenase (SDH), in peripheral blood lymphocytes. Statistical data processing was performed in STATISTICA 10.1 program package. Results. The duration and severity of BOS manifestations increased with age, they were the most prominent in the age group older than 60 y/o. Bronchial asthma was diagnosed for the first time in 85 patients, most of them belonging to the group 18–25 y/o. In all the patients with BOS, the SGRQ coeffitient was above 50, and comorbidity was established in 82.4% of the patients. The longest duration of BOS (49.4±3.5 days) was established in the group older than 60 y/o (n = 86). LDH/SDH ratio decreased from 6 to 4.8–5.2 a.u. in all the age groups. Such changes should be taken into account in the patients from young age groups. Conclusion. The revealed low values of LDH/SDH ratio have not been shown in the available literature earlier. These values demonstrate the development of secondary mitochondrial dysfunction in post-COVID-19 period in both younger and older age groups, particularly, in patients with more severe progression of BOS. Estimation of this parameter would allow to revealthe personified characteristics for each patients, which is important for quantifying the efficacy and duration of the required antioxidant therapy.