bluuebunny/crossref_metadata_2025 huggingface dataset:
Enxerto ósseo para atrofia de mandíbula
Authors: Beltrão Gilson Correa , Zardo Mauricio , Raffin Rosane
Published: April 2020

A atrofia da mandíbula desdentada é, na verdade, um desafio para os protesistas. A dificuldade de copiar as nuanças do rebordo e de confeccionar um aparelho protético estável, nestes casos, é enorme.

No presente trabalho, procuramos demonstrar, através de descrição de um caso clínico, os recursos que a cirurgia, enxerto de crista ilíaca, proprociona como fim. Possibilitando um aumento de rebordo, bem como acidentes anatômicos mais nítidos. Desta forma, procura o protesista desenvolver o seu trabalho com adequada estabilidade.
ÓRGÃOS DE JUVENTUDE NOS ESTADOS DO MARANHÃO, MATO GROSSO DO SUL E RIO GRANDE DO NORTE
Authors: Jardim Andreia Crystina Silva , Souza Melquisedeque Santana de , Souza João Mateus Lima de , Alves Pedro Henrique dos Santos , Shintaku Milton
Published: April 2020

A estrutura brasileira formada pelas esfera federal, estadual e municipal descentraliza ações, compartilhando o poder, mas requerendo articulação entre as esferas. Nesse sentido, requer conhecimento de todos os órgãos que atuam em um tema, como a juventude, que possui um órgão federal: a Secretaria Nacional de Juventude (SNJ). Nesse sentido, o presente estudo tem por objetivo levantar as unidades de juventude municipais nos estados do Maranhão, Mato Grosso de Sul e Rio Grande do Norte, a fim de criar uma amostra do cenário nacional sobre essas unidades. Um estudo misto, com coleta de dados efetuada nos estados, verificou que os estados possuem órgãos de juventude, mas nem todos municípios desses estados possuem.  Da mesma forma, podem-se apresentar indícios de que o tamanho da população não é um fator preponderante para ter ou não unidade de juventude nas cidades brasileiras. Assim, a presente análise procura apoiar estudos sobre a organização políticas dos municípios brasileiros, apresentando uma amostra do cenário sobre a presença das unidades de juventude nas cidades dos estados do Maranhão, Mato Grosso de Sul e Rio Grande do Norte
Profil Toksikologis Ekstrak Daun Tumbuhan Baka-Baka (Hyptis capitata Jacq.) Pada Hati Tikus Putih (Rattus norvegicus)
Authors: Ayu Sitti , Harso Wahyu , Jannah Maghfirahtul
Published: April 2020

Hyptis capitata Jacq. plant has been using for traditional medicine. Utilization of medicinal plant must always consider to given dose because of toxic effect when too much medicine is taken. The aim of this study was to measure the liver damage in mouse caused by H. capitata Jacq. leave extract when it was given an excessive dose. Either 300 (P1), 600 (P2) or 900 (P3) µg H. capitata Jacq. leave extract was given orally to mice every 24 hours during 14 days. Zero point five ml ethanol 96% was given daily (K-) and without given anything (K+) was also conducted as a control. The result showed that mice given P3 treatment had the highest liver damage. The liver damage in mice was not statistically significant difference between P3 and K- treatments. The lowest liver damage was in mice given K+ treatment. There was no significant difference between P1 and P2 treatments on mice liver damage. Utilization of medicinal plant as traditional medicine should always be consider to doses.
FORMULASI MEDIA PRODUKSI JAMUR TIRAM (Pleurotus ostreatus) DENGAN SUPLEMENTASI AMPAS SAGU
Authors: Utami Sri , Umrah Umrah , Suwastika I Nengah
Published: April 2020

This study aims to know the basic media with sago pulp supplementation which can be formulated into a medium for producing white oyster mushrooms and also to know the comparison of the right media and supplements in the formulation to give maximum oyster mushrooms production. In this study using a comparison with sawdust substrate and sago pulp to see how effective the sago pulp substrate as a supplement media for the oyster mushroom production. the program used is experimental designed in Completely Randomized Design (CRD), consists of three replications so that twelve experiments were obtained. The treatment arrangement is M1: Base media without supplements (controls), M2: 90% base media + 10% sago pulp, M3: 80% basic media + 20% sago pulp, M4: base media 70% + sago pulp 30%. The observation parameters used in the study are mycelium growth, fruit body growth, biological efficiency and measurement of protein levels in the fruit body of the oyster mushroom. The results showed that the addition of sago pulp in the media of oyster mushroom production had no effect on the growth of oyster mushrooms. This can be seen from the media of production of M1 (without the addition of sago pulp) experiencing a higher growth rate of mycelium compared to other treatments. The addition of sago pulp has an effect on the levels of oyster mushroom protein. This can be seen from the protein content of oyster mushrooms in M2 production media which have high protein content. Normal levels of white oyster mushrooms in sawdust media range from 18% -20%. This is due to the mixing of wood powder as a production medium and 10% sago pulp as supplementation to produce more nutrient levels.
Catechin-based Dentin Pretreatment and the Clinical Performance of a Universal Adhesive: A Two-year Randomized Clinical Trial
Authors: Costa CAGA , Albuquerque NLG , Mendonça JS , Loguercio AD , Saboia VPA , Santiago SL
Published: April 2020

Clinical Relevance

At 24 months, the dentin pretreatment with epigallocatechin-3-gallate did not impair the clinical performance of the adhesive Single Bond Universal regardless of the bonding strategy used.

Purpose: To evaluate the two-year effect of dentin pretreatment with epigallocatechin-3-gallate (EGCG) on the clinical performance of restorations of noncarious cervical lesions (NCCLs) with Single Bond Universal, applied in two different modes (self-etch and etch-and-rinse).

Methods and Materials: In this randomized clinical trial, 33 volunteers were selected, and 156 NCCLs were assigned to four groups: ER, etch-and-rinse; ER-EGCG, 0.1% EGCG dentin pretreatment + etch-and-rinse; SE, self-etch; and SE-EGCG, 0.1% EGCG dentin pretreatment + self-etch. The NCCLs were restored with a nanofilled resin composite and evaluated at baseline and at six, 12, 18, and 24 months using FDI criteria for retention, marginal staining, marginal adaptation, caries, and postoperative sensitivity. Two evaluators were blinded to the treatments performed, and impressions were taken for resin replicas to allow indirect observations. Statistical analyses were performed with Kruskal-Wallis and McNemar tests with a significance level of 5%.

Results: Six restorations (one from ER, two from SE, one from ER-EGCG, and two from SEEGCG) were lost at 24 months with no significant differences (p>0.05). The retention rates were 97.0% (ER and ER-EGCG), 94.1% (SE), and 94.2% (SE-EGCG). For marginal adaptation, a significant difference was detected between the baseline and 24 months for the SE group (p=0.0313). There were no statistical differences among all other evaluated criteria at 24 months, neither for each group at baseline nor for 24-month comparisons (p>0.05).

Conclusions: The pretreatment with EGCG provided no benefit in the clinical performance of the adhesive regardless of the bonding strategy used. In addition, it adds an additional required step to the restorative procedure.
Students’ Responses Leveling in Solving Mathematical Problem Based on SOLO Taxonomy Viewed from Multiple Intelligences
Authors: Silwana Amalia , Subanji Subanji , Manyunu Muhamatsakree , Rashahan Arifah Adlina
Published: April 2020

This research aimed to determine the level of student response with logical-mathematical, verbal-linguistic, and visual-spatial intelligence tendency in solving mathematical problems of linear programming material based on SOLO taxonomy. The level of students’ responses as the output in this research is expected to be used as a reference by mathematics teachers to determine the appropriate learning methods and strategies in accordance with the tendency of students' multiple intelligence types. It can be useful in realizing the effectiveness of mathematics learning about what needs to improved and emphasized in learning so that all students can achieve optimal responses in solving mathematical problem and can develop their multiple intelligences. This research is descriptive qualitative research with six students in the 11th Grade of SMAN 1 Gondanglegi as research subjects: two students with logical-mathematical intelligence tendency, two students with verbal-linguistic intelligence tendency, and two students with visual-spatial intelligence tendency. Data collection was done by providing multiple intelligence classification tests, linear programming problem tests, and interviews. The result of the research showed the students’ response level in solving the mathematical problem of linear programming material based on SOLO taxonomy is that students with logical-mathematical intelligence tendency reached extended abstract response level, students with verbal-linguistic intelligence tendency reached multistructural response level, and students with visual-spatial intelligence tendency reached multistructural and relational response level.
Клиническое значение диагноза «инфаркт миокарда 2-го типа»
Authors: Barbarash O.L.
Published: April 2020

Представлен краткий обзор истории развития современных представлений о дефиниции диагноза инфаркт миокарда (ИМ) даны предпосылки к формированию четырех универсальных определений инфаркта миокарда. Описаны основные различия в механизме развития и критериях диагностики ИМ 1-го и 2-го типов обобщены данные о частоте выявления, особенностях диагностики и лечения ИМ 2-го типа. Продемонстрированы результаты различных регистровых исследований, отражающих типовую структуру и прогноз при различных типах ИМ. Представлены аргументы о необходимости дальнейших исследований в разделе изучения различных фенотипов инфаркта миокарда, а также подходов к лечению и вторичной профилактике.
Strategies of RT-PCR-based assay design and surveillance of SARS-CoV-2
Authors: Kuznetsova NA , Pochtovyy AA , Nikiforova MA , Guschin VA
Published: April 2020

High population density in the cities with bustling transportation systems and a thriving tourism industry can promote the global spread of a viral infection in a matter of days. The novel SARS-CoV-2 coronavirus has already infected over 2,000,000 people worldwide and caused upwards of 156,000 deaths. One of the factors driving the rapid unfolding of the pandemic is the absence of diagnostic tests for SARS-CoV-2 detection. Molecular techniques allow SARS-CoV-2 RNA to be quickly detected in clinical samples, aiding the differential diagnosis in severely ill patients and facilitating identification of asymptomatic carriers or presymptomatic individuals. Real-time PCR with fluorescent hybridization is the most available, highly sensitive and specific technique for SARS-CoV-2 RNA detection in biological samples. More RT-PCR assay kits are needed for mass screening, which will help to identify infected individuals and contain the current outbreak of COVID-19 in Russia.
Ritual Merenden Tedong sebagai Penyelesaian Konflik Masyarakat Mamasa
Authors: Stepanus Stepanus , Lattu Izak , Tampake Tony
Published: April 2020

The Merenden Tedong ritual is performed by the Toraja Mamasa tribe in Mamasa Regency, West Sulawesi up to now. This study aims to describe the implementation of the Merenden Tedong ritual of the Mamasa community, and then examine the spiritual values contained therein as a solution to community conflict. The motive for doing this research is the threat of social conflict in the community that can cause social disharmony. The method used in this research is qualitative with a descriptive approach. Data obtained through the method of observation, interviews, and analysis. Interviews were conducted with traditional leaders, community leaders, village government and Merenden Tedong ritual practitioners. This research resulted in the following findings: the implementation of the Merenden Tedong ritual in Mamasa included stages: mediation, deliberation, shaking hands and praying, and eating together. While the spiritual values of the Merenden Tedong ritual include: Ma’bisara, Me’renden Tedong, Sitayuk sikamasei Sirande maya-maya, Mesa Kada di Patuo, patang Kada di Pomate and Sipapada. The spiritual values of the Merenden Tedong ritual are a solution to the Mamasa community's conflict and also serves to build peace.
Kekuatan Simbolik Beras dalam Ritus Kehidupan Masyarakat Batak Toba
Authors: Hutasoit Resmi , Lattu Izak M. , Timo Ebenhaizer I Nuban
Published: April 2020

This article aims to analyze the background or history of rice used as a symbol of spirit strengthening in the rites of life stages in the Batak land which are carried out in the adat of marriage, free from distress, promotion, entering a new home also when the child is baptized. The method used is a qualitative method with interview, observation and literature study techniques. The results found that rice has a sacred value for the Batak people. Rice is generally owned by the rich and poor so that there is social equality so that using rice as a symbol of spirit strengthening. Rice provides physical needs for health. Human physical health is very influential on the human spirit. When giving rice in certain events there is an element of safety, when the rice is placed over the head and scattered. They use rice as a symbol in certain rites from generation to generation from their ancestors. Rice for the Batak has a very high historical value from the process of planting rice to rice. This paper contributes to traditional leaders and young people to preserve and understand the traditions of their ancestors.
Kerukunan Umat Beragama di Desa Mopuya: Kajian Teologi Kerukunan Islam, Kristen, dan Hindu
Authors: Pangkey Marcelina Priskila
Published: April 2020

This study aims to describe and analyze the values of religious harmony in the village of Mopuya. This paper, becomes a common reference as social capital, and can sustainably be the main foundation or foundation in caring for the harmony of inter-religious dialogue relations in Mopuya village, Bolaang Mongondouw. Through the relation of religious harmony, the social cohesion of the Mopuya community has so far been maintained. This research uses a qualitative-descriptive approach. Primary data were obtained through in-depth interviews with: village government, religious leaders, and elements of community institutions as representatives of each religion. The results of the analysis of the data obtained show that tolerance of religious harmony that has been applied so far, can be used as the main foundation of inter-religious dialogue relations in Mopuya village. Referring to the values of tolerance which is a pattern of community life as social capital, the Mopuya community is able to offer patterns of inter-religious relations that prioritize relational values. The relationship between religion that has been preserved by the Mopuya villagers shows a social relationship that maintains a peaceful and respectful pluralism.
Analisis Cerita Rakyat Mandailing “Sampuraga”: Suatu Kajian Pendekatan Objektif dan Nilai Pendidikan Karakter
Authors: Hasibuan Nikmah Sari , Puansyah Irman , Hasibuan Ahmad Yamin
Published: April 2020

His study aims to analyze the values of character education in the folklore of Sampuraga that developed in the Mandailng Natal community. This research uses descriptive analytical method, which is a method that is as clear as possible about the object under study, as well as describing the data as a whole, systematically, and accurately. The analysis is carried out using the theoretical basis used, then analyzed and interpreted in accordance with the study of theory so that the results of the research will be able to describe the problems studied objectively, systematically based on the theories the authors use. Based on the results of this study it can be concluded that first, the principle of an objective approach in the process of applying the elements that make up the literary work itself, such as plot, setting, characterization, language style, and perspective. An objective approach to Sampuraga Folklore. Second, there are four values of character education in the folklore of Sampuraga and Nasondang Ngilong-Ilong, namely the value of religious character education, compassion, hard work, and honesty.
Subordinasi Kepemimpinan Perempuan dalam Budaya Batak Toba
Authors: Sibarani Rispritosia , Gulo Yurulina
Published: April 2020

In this paper we analyze the position of women in the social life of the Toba Batak community, in influencing others to do something called a leader. In the context of such thinking, the author wants to see why women in Toba Batak have not experienced development in leadership and want to elaborate on the process of socio-cultural transmigration in Batak Bangso especially Batak Toba in political, social and cultural aspects, the majority of whose leaders are men. This paper uses a descriptive-analytic approach and with a qualitative approach. The results of the study mentioned that women experience gender inequality which is characterized by the occurrence of subordination (numbering) and marginalization of Batak women. In the field of politics, the ideal leadership is always measured from a men's perspective, so that the position of women is increasingly weak in their interaction with the surrounding community. Domestication and marginalization of women in the public sphere seems to have been exhausted and enjoyed by women because they are educated and live in a patriarchal culture by believing and believing in diverting religious teachings that are understood in a discriminatory way, and perpetuating women's alienation.
Evaluasi Program Penguatan Karakter: Studi pada Sekolah Non-Piloting PPK di Kota Malang
Authors: Miharja Fuad Jaya , Kusumawardana Adi Slamet , Setiawan Arif
Published: April 2020

The program for strengthening character education is only carried out in several pilot schools so that there is not much information available to what extent character education has actually been carried out in other schools, especially in non-piloting schools. This study aimed to measure the feasibility of strengthening character education in non-piloting schools. The population in this quantitative descriptive study was teachers at junior high school in Malang. The sampling technique used was purposive sampling. The subjects involved in this study were six teachers of Junior High Schools 20 of Malang, Junior High Schools 27 of Malang, and Muhammadiyah 1 Junior High School. Data collection used questionnaires and analysed descriptively statistically. The results of the study showed that the three schools have implemented character strengthening programs seen from the ten assessment components i.e. pre-assesment, programme socialization, vision, programme design, class-based implementing, school culture strengthening, social partisipation, core value implementing, and evaluation. These results indicated that character strengthening has become a positive habit but not yet optimal. The results of this study can be used as a basis for identifying appropriate follow-up steps for improving achievement of character strengthening in schools.
Implementasi Program Percepatan Pembangunan Wilayah Lingkar Luar Kota Medan
Authors: Ardian Muhammad , Purba Arief Marizki
Published: April 2020

This research aims to analyze the implementation of the Medan Outer Ring Acceleration Area Program in the Medan Tuntungan District and to find out the supporting and inhibiting factors. The research method used is descriptive research method with a qualitative approach. The results showed that the implementation of the accelerated development program for the outer ring region in Medan Tuntungan District was effective and was able to add and improve several facilities and infrastructures, not only road infrastructure, health infrastructure, educational infrastructure, but also added economic infrastructure. Factors that support infrastructure development in the District of Medan Tuntungan include Support of all citizens to government policies through proposals submitted to the Medan City Government regarding the need for infrastructure development in the District of Medan Tuntungan, in the context of accelerating regional development. Factors hampering infrastructure development in Medan Tuntungan Subdistrict are the lack of public awareness of the use and maintenance of infrastructure provided by the government, so that conditions are easily damaged and the limited regional budget for infrastructure development.
Kontribusi Intrapersonal Skills dan Interpersonal Skills Terhadap Kesiapan Kerja Pada Mahasiswa Perguruan Tinggi “X”
Authors: Suhartono Entot , Machmuddah Zaky
Published: April 2020

Empirically proving the relationship between intrapersonal skills and interpersonal skills to work readiness in "X" college students is the aim of this study. The method used in this research is survey. The population in this study were all "X" college students. The sample used in this study was "X" college final semester students. Purposive sampling with accidental sampling is a sampling technique used in this study. Multiple linear regression in the SPSS 15.0 version program is used as a data processing tool. Obtained 185 respondents in this research. Simultaneous test results show that intrapersonal skills and interpersonal skills significantly affect work readiness for "X" college students. Partially intrapersonal skills and interpersonal skills, both of them significantly affect the work readiness of "X" college students. The implication of this research is the importance of education related to soft skills because this greatly contributes to students preparing themselves when joining the workforce.
Minat Siswa Sekolah Menengah Kejuruan Memilih Program Studi Meeting, Incentive, Conference, Exhibition di Politeknik Negeri Medan
Authors: Tambunan Sarah Rouli
Published: April 2020

This paper wants to explain whether vocational students in the field of tourism in Medan are aware of the MICE industry (Meeting, Incentive, Conference, Exhibition) and MICE study programs in Politeknik Negeri Medan (Polmed). Furthermore, how is the interest of tourism vocational school students in Medan before and after being given a stimulus. The research uses descriptive method with quantitative approach. Data collection was carried out through a survey technique using a questionnaire. The respondent is tourism vocational school student in class which is spread in 15 vocational schools in Medan. The results showed that from 150 respondents surveyed, only 52% knew about the MICE industry, even though MICE was related to tourism. Furthermore, only 32% of respondents are aware of the existence of the MICE study program in Polmed. The low knowledge of students about MICE Polmed study program, effect the low interest of respondents in choosing this study program that is only by 8%. However, increased interest was seen when respondents had received stimulus in the form of information about the MICE Polmed study program profile which was displayed using media: books and videos. From 8% of respondents who were initially interested in choosing the MICE Polmed study program, after being given a stimulus it increased to 73.66%.
Model Pendidikan Politik Himpunan Mahasiswa Islam Cabang Padang
Authors: Ilham Fadli , Hasrul Hasrul , Dewi Susi Fitria
Published: April 2020

This article aims to describe how the model of integrated political education based on the five qualities of the Padang branch of the Islamic Student Association (HMI). The problem is focused on the Padang branch HMI integrated political education model. This research uses a qualitative approach. Data is collected through documentation studies, interviews, observations, and FGD (focus group discussion). Data were analyzed using data analysis techniques consisting of data reduction, data presentation and decision making. Data validity was tested by source triangulation. This study concludes that the integrated political education model based on the five qualities of the HMI aspirants of the Padang branch is based on the objectives of the HMI with formal, non-formal and informal forms of political education.
Adaptasi Berbasis Budaya dan Sosial Masyarakat (Studi Kasus Etnis Tionghoa di Kota Palembang)
Authors: Harahap Nursapia
Published: April 2020

Adaptation depends on the structure or physical behavior of an individual that increases his ability to survive in his habitat. Whatever helps him survive in the environment he occupies includes the cultural and social community. Remembering adaptation refers to the ability to adapt to various conditions in their environment. This study aims to analyze the cultural adaptation and social adaptation of ethnic Chinese communities in theory and practice. Then clarify the important role that culture plays in enabling adaptation, and show how community-based cultural and social adaptation is well placed. Besides that it also measures the typical starting point of good community development by emphasizing community participation, kinship systems, individual welfare, culture, community and adaptation. For this reason, in particular this research relies on thoughts that have emerged from observations about the cultural and social role of society in individual lives. The results of this study indicate that the Chinese ethnic has been able to adapt to the cultural and social adaptation of the community well in the city of Palembang. This ability can be seen from the socio-economic life, society and culture of ethnic Chinese who are able to survive with the capital of developing business ventures and working in the political field. In addition, the Chinese are also able to adapt structurally and culturally by following the cultural and community development of Palembang City.kkan
Pengaruh Komunikasi dan Budaya Organisasi terhadap Kinerja Karyawan Head Office PT. TELKOMSEL
Authors: Ferdian Ary , Charitas Luisa Putri Amanda
Published: April 2020

The purpose of this study was to find out how the level of communication, organizational culture, and employee performance, and to determine the effect of communication and organizational culture simultaneously or partially on employee performance in the head office of PT. Telkomsel. The research method used is a quantitative method. Primary data collection techniques with interviews, observations, and questionnaires. Samples were selected as many as 92 employees from a total population of 1,194 employees using simple random sampling technique with the Slovin formula. The analysis technique in this research is descriptive analysis, classic assumption test, and multiple linear regression analysis and coefficient of determination test. Descriptive analysis results show that communication, organizational culture, and employee performance at the head office of PT. Telkomsel are classified as good. Based on the results of hypothesis testing using the t test shows that the communication variables and organizational culture partially have a significant effect on employee performance. While simultaneous hypothesis testing with the F test shows that simultaneous communication and organizational culture significantly influence employee performance. The magnitude of the influence of communication and organizational culture on the performance of PT. Telkomsel is 66.42% and the remaining 33.58% is influenced by other variables.
Interaksi Guru dan Siswa dalam Pembinaan Disiplin Siswa pada Pembelajaran Pendidikan Pancasila dan Kewarganegaraan
Authors: Dewita Emilia , Indrawadi Junaidi
Published: April 2020

This article aims to find out how the interaction of teachers and students in developing student discipline in citizenship learning at SMK Negeri 5 Padang. The method used in this research is descriptive qualitative approach by collecting data through observation, interviews and literature studies. The results of this study indicate that the discipline character of students at SMK Negeri 5 Padang is still not good despite the formation of discipline character by the citizenship teacher. The process of teacher and student interaction in fostering the character of student discipline at SMK Negeri 5 Padang through four stages, namely 1) making rules / agreements in learning citizenship between citizenship teachers and students, 2) Implementation of discipline by students, 3) punishment for students who violate disciplines in citizenship learning and 4) Coaching follow-up. Through this research, it is expected that efforts to increase teacher and student interaction and self-improvement / personality of students, teachers must provide instructions, how to implement discipline properly, provide guidance and assistance to students. This study recommends further research on self-concept in discipline so that it becomes a habit in students.
Assessing the Nutritional Condition of The Elderly: Perspectives of Trained Health Workers and Significant Others in Countryside in Indonesia Inputs to an Action Plan
Authors: Winandari Fransisca
Published: April 2020

Background: Nutrition plays an important role in health maintenance, rehabilitation, and prevention and control of disease for the elderly. If undetected, nutritional problems among the elderly may result in more rapid deterioration of health and early death.  Methods: In this study, the researcher conducted descriptive correlational design to describe the perspectives of trained health workers and significant others on the nutritional condition of the elderly in terms of nutritional screening, nutritional assessment, and nutritional indication score. Results: The population of this study is the trained health workers in Bambanglipuro and the significant others of the elderly who met the inclusion criteria. There are 50 of trained health worker respondents and 112 significant other respondents. Their assessment was assessed by themselves and tested significant differences using the T-test. All the computed t values were less than T values of 1.96. This result shows that the null hypothesis is accepted, meaning there is no significant difference between the assessment of the trained health worker respondents and the significant other respondents on the nutritional condition of the elderly. It proved that the significant others completely knew about the nutritional condition of the elderly.Conclusions: Proposed action plan can be applied for enhancement of the nutritional condition of the elderly, such as to conduct a lecture related to the importance of assessing the physical problems of the patient, conduct a lecture related to the importance of assessing the patient’s mode feeding, conduct a training workshop related how to measure Calf Circumference and Mid-arm Circumference (MAC).
Neonatal Atrial Flutter Approach: A Case Series
Authors: Pessa Valente Fernanda , Henrique Belarmino Góes Gustavo , Bernardi Fabro Caroline , Luiz Tavares Albuquerque Afonso , Celestino Sobral Filho Dário
Published: April 2020

Objective: This study set out to analyze the therapeutic options of patients with neonatal atrial flutter (AFL), considering the diagnostic methods available and the prognosis of these patients. Methodology: A retrospective study was performed by reviewing the medical records of a series of seven patients with atrial fibrillation (AF) diagnosed during fetal or neonatal period. The follow-up time of these patients ranged from 7 months to 3 years and 8 months (mean: 1 year). The clinical data for the diagnosis included sustained heart rate greater than 180 bpm, which was confirmed in all patients by a 12-lead electrocardiogram. Results: Four (57.1%) of the 7 patients studied were male. Most of the patients revealed cardiac arrhythmia during the intrauterine period when screened by fetal ultrasound in the third trimester of gestation (5 patients, i.e. 71.2%). Only the mother of Patient 2 was administered digoxin before childbirth. The atrial rate of the tachyarrhythmia revealed a mean of 375 bpm, with an increase of up to 500 bpm. Atrioventricular conduction presented a 2:1 ratio in all patients, with variations of 3:1 and 4:1 observed in Patients 1, 3 and 6. The ventricular rate ranged from 188 to 250 bpm. All patients revealed typical and counter-clockwise electrocardiogram characteristics. Synchronized electrical cardioversion was the treatment of choice in 6 patients (85.7%), with a dose of 1 J/kg. Conclusion: Early diagnosis, prior treatment, and synchronized electrical cardioversion indicate an excellent prognosis, and prolonged maintenance treatment may be unnecessary.
Low Cost, Sensitive and Selective Chronoamperometric Determination of Vanillin at a Disposable Poly(Eriochrome Black T)/Pencil Graphite Electrode
Authors: KARAKAYA Serkan
Published: April 2020

In this study, low cost, sensitive and selective chronoamperometric determination of vanillin (VNL) is firstly achieved by using a disposable poly(Eriochrome Black T) modified pencil graphite electrode (poly(EBT)/PGE). Electro-oxidation behavior of 1.0 mM VNL was investigated at both poly(EBT)/PGE and PGE by the cyclic voltammetry (CV) method. CV measurements showed that oxidation current of VNL at poly (EBT)/PGE was much higher than the bare one. Furthermore, the pH effect on electro-oxidation current of VNL was tested at different pH values (2.0-8.0) of Britton Robinson Buffer solution (BRBS) for poly(EBT)/PGE and the highest current was obtained at pH 7.0 BRBS. Significant analytical parameters such as linear response range (LRR), limit of detection (LOD), and sensitivity were found as 0.050-10.0 µM, 0.013 µM and 5355 µA mM-1 cm-2, respectively. The fabricated sensor was tested on a VNL-containing sample (VNL content: 3.0%) and the result (3.04% ±0.01) obtained from the applicability study showed that the proposed sensor enables the determination of VNL with high accuracy and precision.
In vitro CULTURE OF BIG-SAGE (Lantana camara L.) PLANT
Authors: Ibrahim Majid Abdulhameed , Sabty Manal Zebari , Mussa Shaimaa Hussein
Published: April 2020

The study was conducted to mass micropropagation of big sage (Lantana camara L.) plant by shoot multiplication technique. The treatments 2.22 and 2.66 µmol·L–1 BA gave the highest significant increase in the percentage of response to shoot multiplication and number of shoots per explant compared to the other treatments as reached 96.70% and 100.00% and 4.33 and 6.00 shoots, respectively. The results showed that these two treatments did not differ significantly between them. While the 1.33 µmol·L–1 BA gave the lowest values in the percentage of response to shoot multiplication and number of shoots per explant were 80.00% and 2.00 shoots per explant, respectively. The MS medium supplemented with 4.30 or 5.37 µmol·L–1 NAA gave a high response to root formation, number of roots per shoot and root length. While the MS medium supplemented with 6.44 or 7.52 µmol·L–1 NAA gave low values in these characteristics. The MS medium with 2.22 or 2.66 µmol·L–1 concentration of BA or 7.52 µmol·L–1 concentration of NAA recorded the highest significant increase in the percentage of response to callus formation. While the MS medium supplemented with 1.33 µmol·L–1 BA or 4.30 µmol·L–1 NAA gave less response to the callus formation.
Toxicological properties of Δ9-tetrahydrocannabinol and cannabidiol
Authors: Černe Katarina
Published: April 2020

Cannabis sativa L. contains more than 100 phytocannabinoids that can interact with cannabinoid receptors CB1 and CB2. None of the cannabinoid receptor ligands is entirely CB1- or CB2-specific. The effects of cannabinoids therefore differ not just because of different potency at cannabinoid receptors but also because they can interact with other non-CB1 and non-CB2 targets, such as TRPV1, GPR55, and GPR119. The most studied phytocannabinoid is Δ9-tetrahydrocannabinol (THC). THC is a partial agonist at both cannabinoid receptors, but its psychotomimetic effect is produced primarily via activation of the CB1 receptor, which is strongly expressed in the central nervous system, with the noteworthy exception of the brain stem. Although acute cognitive and other effects of THC are well known, the risk of irreversible neuropsychological effects of THC needs further research to elucidate the association. Unlike THC, phytocannabinoid cannabidiol (CBD) does not appear to have psychotomimetic effects but may interact with some of the effects of THC if taken concomitantly. CBD administered orally has recently undergone well-controlled clinical trials to assess its safety in the treatment of paediatric epilepsy syndromes. Their findings point to increased transaminase levels as a safety issue that calls for postmarketing surveillance for liver toxicity. The aim of this review is to summarise what is known about acute and chronic toxicological effects of both compounds and address the gaps in knowledge about the safety of exogenous cannabinoids that are still open.
A regulatory take on cannabis and cannabinoids for medicinal use in the European Union
Authors: Lipnik-Štangelj Metoda , Razinger Barbara
Published: April 2020

The discovery of the endocannabinoid system has raised public interest in the medicinal use of cannabis, phytocannabinoids, and synthetic cannabinoids, which has always been closely regulated due to their psychotropic effects and potential abuse. The review takes a quick look at the current legal framework in the European Union, which regulates cannabis use and cultivation for medicinal purposes in line with the United Nations Conventions on the production, trade, and use of cannabis, phytocannabinoids, and synthetic cannabinoids. And while the EU legislation precisely defines requirements and marketing authorisation procedures for medicinal products for all EU member states, there is no common regulatory framework for magistral and officinal preparations containing cannabinoids, as they are exempt from marketing authorisation. Instead, their regulation is left to each member state, and it is quite uneven at this point, mainly due to cultural and historical differences between the countries, leading to different access to non-authorised medicinal products. Therefore, to meet great public interest, harmonised approaches on cannabinoid-containing products without marketing authorisation would be welcome to level the playing field in the EU.
Reproductive disorders in male rats induced by high-fructose consumption from juvenile age to puberty
Authors: Tkachenko Oleksandr Y. , Shayakhmetova Ganna M. , Matvienko Anatoliy V. , Kovalenko Valentina M.
Published: April 2020

There is compelling evidence that a hypercaloric, high-fructose diet can cause metabolic syndrome (MetS) and a whole range of other metabolic changes. In the context of androgen deficiency, MetS in boys merits special attention, but the effects of fructose-rich diet in youth on future male reproductive function are still poorly evidenced. The aim of this study was to address this issue and analyse the effects of high-fructose intake starting from weaning to puberty (postnatal day 23 up to 83) on the reproductive function of male rats. For this purpose juvenile male Wistar rats were divided in two groups: control and the group receiving 10 % fructose solution instead of drinking water. Reproductive function was evaluated in terms of fertility, sperm count, testes/epididymis morphology, and serum sex hormones. The fructose-treated group showed a decrease in testosterone and twofold increase in luteinising and follicle-stimulating hormone levels in the serum. This was accompanied with lower testis/epididymis weights, sperm count, and changed testis/epididymis morphology. Their fertility remained unchanged, but the fertility of females mating with these males diminished. In addition, pre-implantation and post-implantation embryonic death rate rose in these females. Our results have confirmed that high fructose consumption from early age until puberty can impair the reproductive function of male rats, and call for further animal and epidemiological investigation.
Effect of urine adulterants on commercial drug abuse screening test strip results
Authors: Rajšić Ivana , Javorac Dragana , Tatović Simona , Repić Aleksandra , Đukić-Ćosić Danijela , Đorđević Snežana , Lukić Vera , Bulat Zorica
Published: April 2020

Immunochromatographic strips for urine drug screening tests (UDSTs) are common and very suitable for drug abuse monitoring, but are also highly susceptible to adulterants kept in the household, which can significantly alter test results. The aim of this study was to see how some of these common adulterants affect UDST results in practice and whether they can be detected by sample validity tests with pH and URIT 11G test strips. To this end we added household chemicals (acids, alkalis, oxidizing agents, surfactants, and miscellaneous substances) to urine samples positive for amphetamine, 3,4-methylenedioxymethamphetamine (MDMA), tetrahydrocannabinol, heroin, cocaine, or benzodiazepines (diazepam or alprazolam) and tested them with one-component immunochromatographic UDST strips. The UDST for cocaine resisted adulteration the most, while the cannabis test produced the most false negative results. The most potent adulterant that barely changed the physiological properties of urine specimens and therefore escaped adulteration detection was vinegar. Besides lemon juice, it produced the most false negative test results. In conclusion, some urine adulterants, such as vinegar, could pass urine specimen validity test and remain undetected by laboratory testing. Our findings raise concern about this issue of preventing urine tampering and call for better control at sampling, privacy concerns notwithstanding, and better sample validity tests.
Soft nanotechnology: the potential of polyelectrolyte multilayers against E. coli adhesion to surfaces
Authors: Fink Rok , Oder Martina , Jukić Jasmina , Cindro Nikola , Požar Josip
Published: April 2020

Preventing bacterial attachment to surfaces is the most efficient approach to controlling biofilm proliferation. The aim of this study was to compare anti-adhesion potentials of 5 and 50 mmol/L polyelectrolyte multilayers of poly(allylamine hydrochloride)/poly(sodium 4–styrenesulfonate), poly(4-vinyl-N-ethylpyridinium bromide)/ poly(sodium 4–styrenesulfonate), and poly(4-vinyl-N-isobutylpyridinium bromide)/poly(sodium 4–styrenesulfonate) against Escherichia coli. Glass surface was covered with five polyelectrolyte layers and exposed to bacterial suspensions. Poly(4-vinyl-N-ethylpyridinium bromide)/poly(sodium 4–styrenesulfonate) was the most effective against bacterial adhesion, having reduced it by 60 %, followed by poly(4-vinyl-N-isobutylpyridinium bromide)/poly(sodium 4– styrenesulfonate) (47 %), and poly(allylamine hydrochloride)/poly(sodium 4–styrenesulfonate) (38 %). Polyelectrolyte multilayers with quaternary amine groups have a significant anti-adhesion potential and could find their place in coatings for food, pharmaceutical, and medical industry.
Cytotoxic and mutagenic potential of juglone: a comparison of free and nano-encapsulated form
Authors: Erisen Semiha , Arasoğlu Tülin , Mansuroglu Banu , Kocacaliskan İsmail , Derman Serap
Published: April 2020

Despite its evidenced beneficial herbicidal, antibacterial, antiviral, antifungal, and antioxidant effects, the application of juglone (5-hydroxy-1,4,-naphthoquinone) is limited due to its low water solubility and allelopathic and toxic effects. In recent years, research has aimed to overcome these limitations by increasing its solubility and controlling its release through nanoparticular systems. This is the first study to have synthesised and characterised juglone-loaded polymeric nanoparticles and compared them with free juglone for cytotoxicity in mouse (L929 fibroblasts) and alfalfa cells and for mutagenic potential in Salmonella typhimurium TA98/100. Mouse and plant cells treated with free and nano-encapsulated juglone showed a decrease in cell viability in a dose and time-dependent manner, but this effect was significantly lower with the nano-encapsulated form at lower doses. In the TA98 strain with S9, nano-encapsulated juglone did not exhibit mutagenic effects, unlike the free form. Since all results show that juglone encapsulation with polymeric nanoparticles reduced the toxic and mutagenic effects, it has a promising potential to be applied in medicine, food safety, and agriculture.
Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans
Authors: Sekovanić Ankica , Jurasović Jasna , Piasek Martina
Published: April 2020

Human metallothioneins are a superfamily of low molecular weight intracellular proteins, whose synthesis can be induced by essential elements (primarily Zn and Cu), toxic elements and chemical agents, and stress-producing conditions. Of the four known isoforms in the human body MT2 is the most common. The expression of metallothioneins is encoded by a multigene family of linked genes and can be influenced by single nucleotide polymorphisms (SNPs) in these genes. To date, 24 SNPs in the MT2A gene have been identified with the incidence of about 1 % in various population groups, and three of them were shown to affect physiological and pathophysiological processes. This review summarises current knowledge about these three SNPs in the MT2A gene and their associations with element concentrations in the body of healthy and diseased persons. The most investigated SNP is rs28366003 (MT2A −5 A/G). Reports associate it with longevity, cancer (breast, prostate, laryngeal, and in paranasal sinuses), and chronic renal disease. The second most investigated SNP, rs10636 (MT2A +838G/C), is associated with breast cancer, cardiovascular disease, and type 2 diabetes. Both are also associated with several metal/metalloid concentrations in the organism. The third SNP, rs1610216 (MT2A −209A/G), has been studied for association with type 2 diabetes, cardiomyopathy, hyperglycaemia, and Zn concentrations. Metallothionein concentrations and MT2A polymorphisms have a potential to be used as biomarkers of metal exposure and clinical markers of a number of chronic diseases. This potential needs to be studied and verified in a large number of well-defined groups of participants (several hundreds and thousands) with a focus on particular physiological or pathological condition and taking into consideration other contributing factors, such as environmental exposure and individual genetic and epigenetic makeup.
Numerical aspects of two coupled harmonic oscillators
Authors: Asad Jihad , Florea Olivia
Published: April 2020

In this study an interesting symmetric linear system is considered. As a first step we obtain the Lagrangian of the system. Secondly, we derive the classical Euler- Lagrange equations of the system. Finally, numerical and analytic solution for these equations have been presented for some chosen initial conditions.
Comment On “On some Properties of Tribonacci Quaternion”
Authors: Cerda-Morales Gamaliel
Published: April 2020

This short commentary serves as a correction of the paper by Akkus and Kızılaslan [I. Akkus and G. Kızılaslan, On some Properties of Tribonacci Quaternion, An. Şt. Univ. Ovidius Constanţa, 26(3), 2018, 5–20].
Estimates of the Laplacian Spectrum and Bounds of Topological Invariants for Riemannian Manifolds with Boundary II
Authors: Sabatini Luca
Published: April 2020

We present some estimate of the Laplacian Spectrum and of Topological Invariants for Riemannian manifold with pinched sectional curvature and with non-empty and non-convex boundary with finite injectivity radius. These estimates do not depend directly on the the lower bound of the boundary injectivity radius but on the bounds of the curvatures of the manifold and its boundary.