bluuebunny/crossref_metadata_2025 huggingface dataset:
On the article “Das vergessene Geheimnis der menschlichen Liebe. Versuch einer Annäherung” by Gerhard Oberhammer
Authors:   Saint-Petersburg State University, Paribok Andrey V.
Published: July 2021

This article, based on the mentioned text, discusses the style of translation and philosophical research of an eminent Austrian indologist Gerhard Oberhammer. A number of impressive German equivalents of Sanskrit technical terms pro­posed by him is examined. 1. Sanskrit sañjñābelongs to general scholarly and philosophical vocabulary, but it is used by Brahmanist authors mainly in a semi­otic sense, viz., “[technical] term” whereas their Buddhist opponents meant it’s mental counterpart “definite perception”. Indologists before Oberhammer were inclined to biased one sided translations. Oberhammers’ Sprachvorstellung (“lin­guistic perception”) unites both of them. 2. Smṛti (literally – “memory”) is ren­dered by Erinnern with a very appropriate connotation “Interiorisation”. 3. Bhā­vanā is translated not by usual and vague “meditation”, but by Darstellung and Vergegenwärtigung. The main conclusion of the author is reformulated by me as follows: any project of an ultimate personal intimacy have as its prerequisite a variety of transcendence and is therefore realizable only within a spiritual path. I totally agree. The pertinence and profoundness of this statement is substanti­ated by the comparative historical facts and speculations of the Tibetan Buddhist tradition unknown to Oberhammer.
The Doctrine of Śrī (Lakṣmī) and its Origins in Viśiṣṭādvaita-Vedānta
Authors:   Peoples’ Friendship University of Russia, Safina Natalia A.
Published: July 2021

The doctrine of Śrī-tattva (ontology of the goddess Lakṣmī) in the philosophy of viśiṣṭādvaita-vedānta is one of the most disputable. It raises a number of ques­tions within the tradition and from other philosophical schools. The Supreme Re­ality (Brahman) has its personified form, represented as Viṣṇu with his spouse Śrī. However, it is not always clear whether the goddess acts autonomously, or she is completely subordinate to God. Whether it is the potency of God, the metaphysical principle, or she is the Supreme deity along with Viṣṇu. This doc­trine became one of the most disputable between the Tengalai and Vadagalai śrī­vaiṣṇava schools of the South India in the 13th – 14th centuries. The ācāryas criticized various theories about Lakṣmī in the debates and in their works, as to her being the means of liberation (mokṣa), as to her being Paramātmā or just a part of Brahman, as to her being infinite etc. Viśiṣṭādvaita’s philosophers quote the Vedic texts and Pāñcarātra samhitas as the most authoritative sources of knowledge when they explain this doctrine. This article discusses references in these texts to Śrī-Lakṣmī, its nature, attributes and functions, as well as its sta­tus in relation to Nārāyaṇa and the Universe.
Lukács and Dostoevsky: Reading Dostoevsky as a Milestone on the Road to Bolshevism
Authors:   Lomonosov Moscow State University, Puschaev Yuriy V. ,   Institute of Scientific Information on Social Sciences, Russian Academy of Sciences
Published: July 2021

The article is devoted to the influence of the interpretation of the works of the great Russian writer F.M. Dostoevsky on early Lukacs in the pre-revolution­ary years. Reading Dostoevsky’s works played an important role in his transition to the position of Bolshevism. The early Lukacs emphasized that Dostoevsky in­structed his atheist heroes to express their real position. Through the prism of these heroes, he interpreted the problem of revolutionary terrorism, drawing on the works of B. Savinkov. The early Lukacs also saw the greatness of Dosto­evsky in the fact that he was the first in world literature to turn to the “reality of the soul”, began to describe it, while ordinary external life (social ties, social sta­tus, etc.), although generated by the soul, is secondary and insignificant. These ideas of the early Lukacs are a kind of precursor to his future Marxist ideas of reification and alienation. The early Lukacs vehemently denies inauthentic ordi­nary life, but this denial is still metaphysically existential. After his “leap” into a new faith, Lukacs interprets what he previously understood as “inauthentic life” through the prism of early Marx, dialectically and socially-historically, through the categories of “reification”, the socialist revolution, and the prole­tariat as a privileged subject-object of world history. For Lukacs, the Marxist, the true reality will no longer be the individual soul, but the social totality and prac­tice. However, it is characteristic that Lukacs’ path to unconditional acceptance of the philosophy of Marxism and Bolshevism lay, among other things, through his fascination with the work of Dostoevsky
The Number and the Kantian Research Program in Modern Neuroscience
Authors:   Immanuel Kant Baltic Federal University, Bazhanov Valentin A.
Published: July 2021

The article presents the attempt to consider the Kantian research program in modern neuroscience in its part, which relates to the representation of the “number” and the mechanisms for processing numerical information by neu­ral structures. We claim that Kantian ideas about the a priori nature of certain mathematical categories related to the status of space and time [geometry and arithmetic], which were subjected to doubt as a result of the discovery of non-Euclidean geometries, proved to be highly demanded and reassessed as a result of the intensive progress of modern cognitive and cultural neuroscience. The dis­covery of the subitizing phenomena, “sense of number” and “sense of place” (analogous to the navigation system of the brain) push us to recall the old Kan­tian judgments concerning certain a priori constructions of mathematics. The on­togenetic foundations of such phenomena, their conditionality by the features of the functioning of the brain, reveal not the metaphorical, but the strategic nature of the Kantian research program in modern neuroscience. In the context of these studies, it also turned out that in the case of living systems, one can speak about their proto-arithmetic traits, and in the case of humans, mathematical abilities that are largely independent of the language, and their systematic development from an early age significantly increases the likelihood of successful mathemati­cal activity in future. Attention drawn to the interdependence of the activity of the developing brain, social and cultural contexts, which intersects and expressed in the process of acculturation of the brain and vice versa – neural determination of culture. This kind of interaction support the idea of the possibility of expand­ing original Kantian idea and introducing the idea related to the transcendental­ism of the activity type
R. Barnett’s Concept of Ecological University on the Role of the University in the World and for the World (Reflections on the Book)
Authors:   National Research Tomsk State University, Chernikova Daria V. , Chernikova Irina V. ,   National Research Tomsk State University
Published: July 2021

The paper is devoted to the reflections on the work of Ronald Barnett The Ecological University: A Feasible Utopia. The research field of social philosophy of higher education is emerging, and the work of Barnett lays the foundations for the philosophical analysis of the university. It is shown that the ecological university is viewed not as another formation of the university among the many existing today, but as a counterform of the university, opposing such university models as entrepreneurial and digital universities. Applying the ecological ap­proach to the university will require a revolutionary transformation in thinking, denoting such a turn as shaping the university’s ecosophy. It is emphasized that the ecological university interacts with the world not in an instrumental, technical way, but rather in a transcendental, hermeneutic way: not through the imposition of changes, but through understanding. Particular attention is paid to the following main ideas of the book: the application of an ecosophical approach to the analysis of the new identity of the university in a changing world, a new vision of the interaction between the university and the larger world, based on the ethics of responsibility for the well-being of ecosystems in which the university is involved, and also the ideas of the knowledge ecology and epistemic responsibility. The urgent imperative of the ecological approach to rethinking the identity and the future of the university as a social institution is substantiated, starting from the concept of “deep ecology” the university builds new forms of interaction with the world. The main principles of this interaction are integrity, responsibility and critical dialogue. The authors believe that the research optics of the social and philosophical analysis of the university actualizes the purpose, responsibilities and influence of the university in the changing world.
Systemic Amyloidosis as a Rare Complication of IgG4 Related Disease: Case Report and Literature Review
Authors: Mendonca Leonardo Oliveira , Antila Henrikki Gomes , Prado Alex Isidoro , Fonseca Luiz Augusto Marcondes , Martins Miton de Arruda , Dyer Rafael , Kalil Jorge , Morato-Castro Fabio Fernandes , Toledo-Barros Myrthes Anna Maragna
Published: July 2021

Immunoglobulin 4 Related Disease (IgG4-RD) is immune-mediated fibroinflammatory disease and despite recent advances the immunological process involved in the disease pathogenesis is still unclear. Serum amyloid A (SAA) the precursor protein in AA amyloidosis is induced by inflammatory mediators such as IL-1, IL-6 and TNF cytokines. The treatment of AA amyloidosis is directed by the theoretical cytokine involved in the underlying inflammatory condition. Many inflammatory conditions has already been associated to AA amyloidosis and secondary to IgG4-RD seems to be rare. Here we report the case of a Brazilian patient with IgG4-RD with a fatal evolution of systemic amyloidosis. We also revised the cases already reporte in the literature with IgG4-RD and systemic amyloidosis.
Filipino Nurses in Cebu City Reveal High Level of Knowledge, Attitudes, Practices and Willingness in Providing Care to COVID-19 Patients: A Cross-Sectional Analysis
Authors: Denney Brian Mortejo , Astor Alexandra , Cabrilles Joanna , Codera Kristiane , Forteza Edzil Marice , Ihara Mugen , Lagudas Mary Farrah , Pesante Kathleen Kaye , Tam Jae Christelle
Published: July 2021

Background

COVID-19 is a rapidly spreading illness and has resulted in a global pandemic. In the Philippines, active cases of COVID-19 are rising and have threatened both local health and healthcare workers given the limited information on this new disease. Despite several studies conducted to assess the awareness, knowledge, attitude, practices, and willingness of nurses to provide care during this pandemic, there are scarce reports regarding Filipino nurses. Thus, our study assessed such criteria in staff nurses across different Cebu hospitals.
Methods

This study utilized a descriptive research design using the cross-sectional survey method. A web-based survey and convenience sampling method was adopted to collect the data from Filipino nurses from any hospital in Cebu, of which, 137 participated in the study. A 43-item questionnaire was developed, which was spread out into 5 parts that comprised of the demographic profile, knowledge (15 items), attitude (10 items), practices (9 items), and willingness to care for patients with COVID-19 (9 items). The data was processed and analyzed using inferential statistical tools.
Results

Majority of the nurses were females (70.80%), whose ages were 20–25 years old (54.01%), single (89.78%), mostly college degree holder (90.51%), and employed in hospitals for 1–3 years (64.96%). They also rely on the internet (99.27%) as a source of information related to COVID-19. They also displayed an overall knowledge of 65% especially about the COVID-19 causative agent, its transmission, and pathogenesis. Furthermore, the respondents were generally knowledgeable of the various information regarding COVID-19 at a rate of 79.56%. The mean values for attitude, practices, and willingness to provide care were 4.45 (very favorable), 4.65 (always), and 4.52 (very willing) respectively.
Conclusions

Generally, the results of our study were favorable across the 5 parts of the survey. Overall knowledge and extent of practice was high, which can be attributed to government efforts of educating healthcare workers and observance of the mandated protocols. In addition, attitude significantly affected the willingness of the nurses to provide care. However, knowledge and practice did not affect the nurses’ willingness as the drawbacks and demands of their occupation outweighed and decreased their willingness.
Acquired Nasolacrimal Duct Obstruction: Clinical and Histological Findings of 275 Cases
Authors: Makselis Almantas , Petroska Donatas , Kadziauskiene Aiste , Jaruseviciene Ruta , Ruzgys Andrius , Cimbalas Andrius , Besusparis Justinas , Asoklis Rimvydas
Published: July 2021

Background: Acquired nasolacrimal duct obstruction is a blockage of the lacrimal outflow system usually caused by a local non-specific inflammation of the lacrimal sac and the nasolacrimal duct. However, cases exist where the primary nasolacrimal system obstruction was caused by malignancies. Our aim was to investigate lacrimal sac pathologies in patients with acquired nasolacrimal duct obstruction and compare its clinical manifestations. Methods: The retrospective clinical study included 275 cases with acquired nasolacrimal duct obstruction who underwent external dacryocystorhinostomy and lacrimal sac biopsy. Cases were classified into tumor or non-specific pathology groups subdivided according to the level of inflammation. Histological and clinical data were analyzed.Results: Three tumors (1.1%) (adenoid cystic carcinoma, eccrine spiradenoma and small B cell lymphoma) were diagnosed. Chronic non-granulomatous inflammation was the most common histological finding, corresponding to 194 cases (70.5%). Other 81 (29.5%) were subacute, chronic forms of non-granulomatous inflammation, tumor and fibrosis cases. Epiphora with continuous purulent discharge was the most common clinical sign reported by 144 (52.4%) patients, two (0.7%) patients had a palpable mass near the medial canthal tendon, which were identified as an eccrine spiradenoma and small B cell lymphoma. There was no significant difference in the clinical symptoms, its’ duration or case history between the non-specific pathology and the tumor groups (p = 0.292). Conclusions: Chronic non-granulomatous inflammation of the lacrimal sac was the most frequent etiology of acquired nasolacrimal duct obstruction. There were no associations between the histological findings and clinical presentation. The authors recommend a lacrimal sac biopsy only in cases when a tumor is clinically suspected.
LncRNA SLC16A1-AS1 Contributes to the Progression of Hepatocellular Carcinoma Cells by Modulating miR-411/MITD1 Axis
Authors: Duan Chun , Quan Bin , Wang Ni , Yang Jianghua , Yu Yan-Lin
Published: July 2021

Background: Hepatocellular carcinoma (HCC) is a common malignancy with high morbidity. The current study aimed to explore the molecular mechannism of lncRNA SLC16A1-AS1 in the tumorigenesis of HCC.Material and Methods: The expression of SLC16A1-AS1 and miR-411 were examined in clinical HCC tissues. HCC cell lines Hep3B and Huh-7 were employed and transfected with si-SLC16A1-AS1. The correlation between SLC16A1-AS1 and miR-411 was verified by luciferase reporter assay. Cell viability was detected by CCK-8 assay. Cell migration and invasion capacity were examined by transwell assay. The protein level of MITD1 was analyzed by western blotting.Results: The expression of SLC16A1-AS1 markedly increased in HCC tissues and cell lines. Subsequent studies identified SLC16A1-AS1 as a downstream target of miR-411. In addition, SLC16A1-AS1 knockdown and miR-411 overexpression significantly stagnated progression of HCC cells. SLC16A1-AS1 knockdown also downregulated MITD1 levels. Conclusion: Our findings showed that SLC16A1-AS1 was overexpressed in HCC cells and tissues. SLC16A1-AS1 promoted the malignant characteristics of HCC cells and acted as an oncogene. Its regulatory effect may be associated with miR-411/MITD1 axis. Therefore, SLC16A1-AS1 has a potential be used as a biomarker or therapeutic target for the treatment of HCC.
Selection, Optimization and Compensation Strategies and Their Relationship with Well-Being and Impulsivity in Early, Middle and Late Adulthood in a Polish Sample
Authors: Zając-Lamparska Ludmiła
Published: July 2021

Background: Selection, optimization and compensation strategies (SOC strategies) are the life management strategies that contribute to successful development. The studies conducted so far have consistently indicated a relationship between the use of these strategies and well-being. In contrast, the relationship between SOC strategies and impulsivity has not yet been empirically examined, although there are premises to assume its existence. The aim of the study was to compare the use of SOC strategies in early, middle and late adulthood, and to investigate the relationship between the use of SOC strategies and well-being and impulsivity. In addition, the study involved a newly developed Polish version of the SOC Questionnaire (SOC48-PL).Methods: The study sample comprised 589 Poles from three age groups: early adulthood (n = 186, 20-35 years), middle adulthood (n = 165, 40-55 years) and late adulthood (n = 238, 60-85 years). In the study, in addition to the SOC48-PL questionnaire, the Short Depression-Happiness Scale (SDHS) and the Short UPPS-P Impulsivity Scale (S UPPS-P) were used.Results: Developmental differences in the use of SOC strategies are rather slight, with a considerable individual differences within age groups. The study revealed some indications of a “developmental peak” of SOC strategies in middle adulthood. The use SOC strategies is positively related to well-being. In turn, the relationship between the use of SOC strategies and impulsivity is negative, especially for two dimensions of impulsivity: lack of premeditation and lack of perseverance. Conclusions: The results only slightly confirm the assumed age-related differences in the use of SOC strategies and point to a large role of individual differences. The revealed relationships of SOC strategy use with well-being and impulsivity are consistent with expectations. The results obtained in the Polish sample confirm the repeatedly revealed positive role of the SOC strategies use for well-being. In contrast, the negative association of SOC strategy use with impulsivity may suggest that for impulsive individuals, spontaneous use of these life-management strategies may be difficult and less likely than those with low impulsivity.
Deacetylation Induced Nuclear Condensation of HP1γ Promotes Multiple Myeloma Drug Resistance
Authors: Liu Zhiqiang , Li Xin , Wang Sheng , Xie Ying , Jiang Hongmei , Wang Jingjing , Guo Jing , Wang Qiang , Ye Lingqun , Wang Yixuan , Peng Ziyi , Wang Mengqi , Wang Jingya
Published: July 2021

Acquired chemoresistance to proteasome inhibitors (PIs) is a major obstacle that results in failure to manage patients with multiple myeloma (MM) in the clinic; however, the key regulators and underlying mechanisms are still unclear. In this study, we found that high levels of a chromosomal modifier, heterochromatin protein 1 gamma (HP1γ), are accompanied by a low acetylation level in bortezomib-resistant (BR) MM cells, and aberrant DNA repair capacity is correlated with HP1γ overexpression. Mechanistically, the deacetylation of HP1γ at lysine 5 by histone deacetylase 1 (HDAC1) alleviates HP1γ ubiquitination, and the stabilized HP1γ recruits the mediator of DNA damage checkpoint 1 (MDC1) to induce DNA damage repair. Simultaneously, deacetylation modification and MDC1 recruitment enhance the nuclear condensate of HP1γ, which facilitates the chromatin accessibility of genes governing sensitivity to PIs, such as FOS, JUN and CD40. Thus, targeting HP1γ stability using the HDAC1/2 inhibitor, romidepsin, sensitizes PIs treatment and overcomes drug resistance both in vitro and in vivo. Our findings elucidate a previously unrecognized role of HP1γ in the acquired drug resistance of MM and suggest that targeting HP1γ may be efficacious for overcoming drug resistance in MM patients.
Effect of pH on the Conformational Transition of Silk Fibroin in Aqueous Solution Monitored by Thioflavin-T Fluorescence
Authors: Jia Ben , Jia Lan , Zhu Jingxin
Published: July 2021

In this work, the potential application of the fluorescence dye Thioflavin-T (ThT), which can specifically bind to amyloid, as a powerful tool for monitoring secondary structure transitions of silk fibroin (SF) induced by pH was examined. Results showed that ThT emission intensities substantially increased when pH decreased from 6.8 to 4.8. This increase may be due to conformational transitions from random coil to β-sheet. The morphology and secondary structure of SF were also investigated via TEM, AFM and circular dichroism spectroscopy. The information obtained herein can be utilized not only for the development of convenient and efficient noninvasive method for monitoring the assembly behavior of SF in aqueous solution but also for in vitro fluorescence imaging.
Formation Mechanism of Well-Ordered Densely Packed Nanoparticle Superlattices Deposited from Gas Phase on Template-Free Surfaces
Authors: Liu Chang , Liu Fei , Jin Chen , Zhang Sishi , Zhang Lianhua , Han Min
Published: July 2021

Superlattices of nanoparticles are generally produced based on solution chemistry processes. In this paper, we demonstrate that self-assembled monolayer structures of nanoparticles with superlattice periodicities can also be produced on template-free surfaces in the gas phase cluster beam deposition process. It is found the packing of Fe nanoparticles corresponds to an average two-dimensional densely-packed lattice with a hexagonal summary. By controlling the nanoparticle coverage, the two-dimensional densely-packed monolayer morphology can spread to the whole substrate surface being deposited. A formation mechanism of the ordered monolayers is proposed by considering the balance between the diffusion rate of the nanoparticles and their filling speed on the substrate surface determined by the deposition rate, and the ordering driven by the inter-particle attractive forces. The model is strongly supported by a serial of carefully designed cluster deposition experiments.
Panel of COVID-19 phenotypes: systematic review protocol
Authors: Silveira Luciana Carvalho , Moraes Yanca Carollynne Souza , Santos Rodrigo da Silva , Reis Angela Adamski da Silva
Published: July 2021

Background The pandemic caused by the SARS-CoV-2 virus, called coronavirus disease 2019 (COVID-19), had an unexpected impact on much of the world, especially Brazil. People diagnosed with the virus manifest different levels of respiratory symptoms, ranging from mild to severe, and may need mechanical ventilation support. The interaction different factors lead to the development of a spectrum of time-related diseases in different phenotypes. Methods This review will consider observational studies published from December 2019 to July 2021, without language restrictions. Studies involving human subjects, adult participants (18 years and older), with subjects who have received a COVID-19 diagnosis using the reverse transcriptase polymerase chain reaction (RT-PCR) test as a reference for the detection of the SARS- CoV-2 virus, according to World Health Organization (WHO) guidance. The databases to be searched will include PubMed/MEDLINE, EMBASE, and CINAHL. The grey literature will also be searched for published research and unpublished studies, using Google Scholar. wo reviewers will independently screen all citations, full-text articles and abstract data. Potential conflicts will be resolved through discussion. Findings will be reported using a narrative synthesis of the results will be carried out around the prevalence, severity of the disease, mortality and risk among the different phenotypes of COVID-19. The I 2 statistic will be used to examine the heterogeneity between the studies, if possible, the meta-analysis will be conducted using the RStudio® statistical software package, and the data will be displayed using forest graphics. Discussion This review will disclose a panel of the different manifestations of the disease COVID-19, and to identify the real risk factor for the most serious phenotypes. Systematic review registration This protocol has been registered within the International Prospective Register of Systematic Reviews (PROSPERO)(CRD42020211439)
Necrosis, as Identified on Pre-Radiotherapy 18F-FDG PET/CT, is a Predictor for Complete Metabolic Response in Patients with Non-Small Cell Lung Cancer.
Authors: Eren Gülnihan , Kupik Osman
Published: July 2021

Purpose: To investigate necrosis on pre-radiotherapy (RT) 18F-FDG PET/CT (PETNECROSİS) is a predictor for complete metabolic response (CMR) in patients with non-small cell lung cancer (NSCLC).Methods: We studied patients with inoperable stage I-III NSCLC who underwent pre- and post-radiotherapy 18F-FDG PET/CT. The relationship between CMR and PETNECROSIS, SUVmax, gross tumor volume calculated with 18F-FDG PET/CT (GTVPET-CT), tumor size, histology, metabolic tumor volume (MTV), and RT dose was assessed using logistic regression analysis. To evaluate necrosis on 18F FDG PET/CT, we drew a region of interest (ROI) in the area showing visually very low/or no fluorodeoxyglucose (FDG) uptake on PET images. If the SUVmax was lower than the blood pool SUVmax and showed significantly lower attenuation [10 to 30 Hounsfield Units (HU)] from the surrounding tissue on non-intravenous contrast-enhanced low dose correlative CT, we defined it as necrotic (PETNECROSİS).Results: Fifty-three patients were included in the study. The mean age was 68.1±9.8 years. Twenty-one patients had adenocarcinoma, 32 had squamous cell carcinoma. All parameters were independent of histologic status. Multivariate logistic regression analysis showed that, SUVmax ≤11.6vs>11.6 (p=0.003, OR:7.670, 95CI%:2.013-29.231) and PETNECROSİS absence/presence were independent predictors for CMR (p=0.028, OR:6.704, 95CI%1.214-30.394).Conclusion: The necrosis on 18F FDG PET/CT and SUVmax>11.6 could be an imaging marker for the complete metabolic response after chemoradiotherapy or RT alone in patients with NSCLC.
COVID-19 Vaccine Hesitancy among University Students in Lebanon
Authors: Hamdan Mirna Bou , Singh Shipra , Polavarapu Mounika , Jordan Timothy , Melhem Nada
Published: July 2021

Background
Lebanon has one of the lowest reported COVID-19 vaccine acceptance rates (21%). Little is known about the decision-making process of college students in Lebanon regarding obtaining a COVID-19 vaccination. Therefore, the aim of this study was to identify factors that predicted the behavioral intentions of students enrolled at the American University of Beirut (AUB), Lebanon to obtain a COVID-19 vaccine.
Methods
The study was a randomized, non-experimental, and cross-sectional study of undergraduate and graduate students. A valid and reliable survey was developed. A total of 3,805 students were randomly selected to participate from all academic units. A total of 800 students responded (21% return rate).
Results
We generated three groups based on students’ intentions to be vaccinated: 1) vaccine accepting (those who are willing to take or already took the vaccine); 2) vaccine hesitant (those who are hesitant to take the vaccine); and 3) vaccine resistant (those who decided not to take the vaccine). The majority were Lebanese (85%), undergraduate students (75%), females (57%) with a mean age of 21 ± 0.14 years. Overall, students were vaccine accepting. Specifically, they were vaccine accepting (87%), vaccine hesitant (10%), and vaccine resistant (3%). Vaccine hesitancy was significantly associated with nationality, residency status and university rank (p value < 0.05). Moreover, there was a significant association between hesitancy and agreement with conspiracies. A significant factor for hesitancy was disagreement with the statement that symptomatic cases are the only carriers of COVID-19 (OR = 5; 95% CI = 1.67–14.29; p value = 0.004). Students believed that that the vaccine was safe (OR = 0.01; 95% CI = 0.002–0.08; p value = 0.000); in agreement with their personal views (OR = 0.1; 95% CI = 0.02–0.51; p value = 0.004) and were less likely to be hesitant than the vaccine accepting group (reference group).
Conclusion
The factors identified that explain and/or predict each of the three vaccine intention groups can be used as core content for health communication and social marketing campaigns to increase the rate of COVID-19 vaccination.
Intertidal community of fucoid seaweeds in the Yarnyshnaya Bay, the Barents Sea
Authors: Kapkov Valentin Ivanovich , Shoshina Elena Vasilyevna , Stepanyan Oleg Vladimirovich
Published: July 2021

The specific and spatial structure of benthic algal community on the littoral zone in the east area of Murman coast of the Barents Sea (69°11'78''N, 36°04'38''E) has been studied in the conditions of anthropogenic influence absence. As a material for studying indicators of fucoid community and populations of dominating species in connection with habitats own long-term seasonal observations and data of scientific expeditions of 1994-2017 have served. The species composition of littoral phytocenosis consists of 39 species including 18 brown, 9 red and 12 green seaweeds, with prevalence on number of annual and seasonal species, on a biomass - perennials. Ecological factors influence essentially on seaweed distribution in different sites of the littoral zone. The major abiotic factors are presence of firm substratum, surf and storms, ice motion. Seaweed littoral community had multi-level structure, in which the basic layer was occupied by brown seaweeds with numerous litophytes and epiphytes under beds and on thallus of dominant species. The community algal biomass in the littoral zone was from 2.8 ± 0.6 up to 17.7 ± 2.9 kg/m² and depended on the species structure, substratum for benthic seaweeds, surf and tides. The biomass and density of fucoid seaweeds varied over a wide range in different biotopes under a natural rigid press of seasonal changes of environmental factors (temperature, surfs, storms) during tides and under natural damages of littoral community in the arctic region. As a whole littoral fucoid phytocenosis of the bay could be considered as an example of adaptation of seaweeds populations to the conditions of the northern seas. The received results could be useful for estimating ecological status of coastal ecosystem, at stock assessment of commercial seaweeds and for algal aquaculture development in the Barents Sea.
Analysis of atmospheric emissions in Murmansk and their relationship with pollution of urban lakes
Authors: Postevaya Marina Alexeevna , Slukovskii Zakhar Ivanovich
Published: July 2021

The main sources of anthropogenic emissions into the atmosphere of Murmansk are emissions from thermal power plants and boiler houses operating on fuel oil. As a result of the analysis of the dynamics of pollutant emissions from stationary anthropogenic sources for the period 1997-2019 it has been established that the level of air pollution is assessed as low; there is a tendency towards a decrease in gross emissions from stationary sources. The main pollutants from thermal power plants are sulfur dioxide, nitrogen oxides, carbon monoxide, formaldehyde, and benzo(a)pyrene. Together with gaseous and liquid substances, fuel oil ash and products of incomplete underburning of fuel, which include heavy metals V, Ni, Cr, Pb, Fe, Sn, enter the atmospheric air. Technogenic compounds of heavy metals and other pollutants from the enterprises of the power unit, falling out with dust or precipitation on the surface and catchment areas of lakes, affect the formation of the chemical composition of surface soils, waters and bottom sediments of water bodies. This is reflected in an increase in the concentration of heavy metals (in particular, V and Ni) in the water and bottom sediments of the lakes of Murmansk in comparison with the background values.
The effect of biopreparations of nodules bacteria with carmoisine on the formation and functioning of the soybean – Bradyrhizobium japonicum symbiotic systems
Authors: Kukol Ekaterina , Vorobey Nadiya , Pukhtaievych Petro , Kots Sergii
Published: July 2021

Purpose. Investigate the formation and functioning of symbiotic systems of soybeans with nodule bacteria by ino­culation of seeds with biological products based on fungicide-resistant strains of Bradyrhizobium japonicum PC07 and B78 with different rates of synthetic carmoisine colorant.
Methods. Physiological, microbiological, gas chromatography, statistical.
Results. It was found that as a result of inoculation of soybean [Glycine max (L.) Merr] variety ‘Almaz’ with microbial preparations based on B. japonicum PC07 and B78, with the addition of carmoisine (0.25 and 0.5 g per 200 g of the preparation), the amount and the weight of nodules formed on the roots during the growing season were at the level of the control plants or exceeded them. The greatest difference in indicators of quantity and weight of root nodules between plants of control and experimental variants is noted in a phase of full flowering at inoculation by both strains of rhizobia and addition to biological products of various norms of dye. Analysis of nitrogen-fixing activity (NFA) of the formed symbiotic systems showed the absence of a negative effect of the synthetic colorant on its level. When inoculated with soybean seeds B. japonicum PC07 in the phase of three true leaves, NFA was higher by 15.6–25.9% and in the budding-beginning of flowering stage by 7.4–29.5% compared with control plants with the addition of 0.25 and 0.5 g of carmoisine, respectively. Against the background of bacterization of soybean seeds by strain B78 before the phase of full flowering of plants the level of N2 assimilation by adding 0.25 g of carmoisine to the vermiculite preparation was at the level of the control plants. During the period of full flowering, this figure exceeded the indicators of control plants by 7.6 and 18.8% with the introduction of 0.25 and 0.5 g of the colorant.
Conclusions. Carmoisine can be applied in the further study of the effectiveness of its use as a dye identifier for controlling the uniformity of marking of loose bacterial preparations on seeds by adding 0.25 and 0.5 g per 200 g of a biopreparation, since this did not show a negative impact on the formation and functioning of the soybean – Bradyrhizobium japonicum symbiotic systems.
Entrepreneurial competencies and intentions among students of technical universities
Authors: Wasilczuk Julita , Chukhray Nataliya , Karyy Oleh , Halkiv Lіubov
Published: July 2021

The study investigates the entrepreneurial competencies and intentions of students. Their formation is a requirement of modern times. The question arises whether students of modern technical universities get entrepreneurial competencies and whether they transform these competencies into their entrepreneurial intentions. More than 3.6 thousand students from six technical universities from Poland, Ukraine, Latvia, Bulgaria, and Lithuania were surveyed. Methods of summarizing and grouping data, analysis of the structure of the population and distributions of its elements, evaluation of relationships were used to analyze the results of the survey. It was found that studying at technical universities is not an obstacle to the existence of entrepreneurial intentions among students. The respondents positively assessed their ability to recognize market opportunities for new business (the sum of the shares of positive answers exceeded the sum of the shares of negative answers by 12.4%). A positive generalized assessment was determined when assessing the ability to persuade others to invest in their business, while negative – their ability to write a formal business plan. It is proved that students who highly value their entrepreneurial abilities are much more likely to show the intention to start their own business (р < 0.001). Students’ focus on starting their own business is partly explained by the fact that they connect employment in corporations with a low guarantee of job retention. High positive integrated assessments received the following advantages of own entrepreneurship: prestige (0.302), chance to be realized (0.362), and the ability to create jobs (0.597).
Acknowledgment The authors wish to thank Denislava Yordanova (Sofia University, Bulgaria), Tatjana Nikitina (Riga Technical University, Latvia), and Daiva Jurevičienė (Vilnius Gediminas Technical University, Lithuania) for helping to collect data at respective countries.
Kinetic and thermodynamic studies of polyvinyl chloride composite of manganese oxide nanosheets for the efficient removal of dye from water
Authors: Saeed Tooba , Naeem Abdul , Mahmood Tahira , Khan Afsar , Ahmad Zahoor , Hamayun Muhammad , Khan Ihtisham Wali , Khan Nazish Huma
Published: July 2021

Manganese oxide nanosheets and manganese oxide composite with polyvinyl chloride (MnO2-PVC) were synthesized by the oxidation method for the efficient removal of Congo red (CR). The Fourier transform infrared spectroscopy, X-ray diffraction, energy dispersive X-ray, surface area (SA), point of zero charge (PZC) and thermogravimetric analysis were performed to verify the newly synthesized adsorbents. After functionalizing the surface of MnO2 nanosheets with PVC, the PZC and SA were amplified from 4.10 and 214 m2g−1 to 5.01 and 226 m2g−1, respectively. The batch adsorption results showed that the removal capacity of CR on both the adsorbents decreased with the increase of pH and time, but increased with the increase of adsorbent dosage. However, due to the high stability, porosity and greater surface area, the PVC composite of MnO2 was found to exhibit 15 times greater CR removal efficiency than its parent MnO2. Furthermore, the thermodynamic parameters specified that CR adsorption onto both the adsorbents was exothermic, spontaneous and film diffusion accompanied by the intraparticle diffusion is the rate controlling step. These results validate that MnO2 composite with PVC is a useful, eco-friendly, competent candidate for dye removal from wastewater.
The Role of PCSK9 in Infectious Diseases
Authors: Magnasco Laura , Sepulcri Chiara , Antonello Roberta Maria , Di Bella Stefano , Labate Laura , Luzzati Roberto , Giacobbe Daniele Roberto , Bassetti Matteo
Published: July 2021

Background:

In recent years, many aspects of the physiological role of PCSK9
have been elucidated, in particular regarding its role in lipid metabolism, cardiovascular
risk but also its role in innate immunity. Increasing evidence is available on the involvement
of PCSK9 in the pathogenesis of viral infections, mainly HCV, as well as in the regulation
of host response to bacterial infections, mainly sepsis and septic shock. Moreover,
the action of PCSK9 has been investigated as a crucial step in the pathogenesis of malaria
infection and disease severity.

Objective:

Aim of this paper is to review available published literature on the role of
PCSK9 in a wide array of infectious diseases.

Conclusion:

Besides the ongoing investigation on PCSK9 inhibition among HIV-infected
patients for the treatment of HIV- and ART-related hyperlipidemia, preclinical studies indicate
how PCSK9 is involved in reducing the replication of HCV. Moreover, a protective
role of PCSK9 inhibition has also been proposed against dengue and SARS-CoV-2 viral
infections. Interestingly, high plasmatic PCSK9 levels have been described in patients
with sepsis. Finally, a loss of function in the PCSK9-encoding gene has been reported to
possibly reduce mortality in malaria infection.
Electrochemistry: A Useful Tool in the Synthesis of Oligothiophenes
Authors: Pandolfi Fabiana , Bortolami Martina , Feroci Marta , Mattiello Leonardo , Scarano Vincenzo , Rocco Daniele
Published: July 2021

Thiophene derivatives, either “small molecules,” oligomers, or polymers, play a
role of primary importance among organic semiconductors, therefore, they have numerous
and different technological applications in the field of Organic Electronics. For this reason,
thiophene-based materials are found in devices, such as Organic Light-Emitting Diodes
(OLEDs), Organic Field-Effect Transistors (OFETs), organic solar cells (OSCs), organic photodetectors,
etc. Oligothiophenes and polythiophenes have common excellent charge transport
properties and synthetic procedures that are now well established. Furthermore, oligothiophenes
do not possess the intrinsic disadvantages of polythiophenes, such as the lack of welldefined
structures and the inevitable presence of impurities. Electrochemistry can give a significant
contribution to the field of oligothiophenes not only by allowing the determination of
the Highest-Occupied Molecular Orbital (HOMO) and the Lowest-Unoccupied Molecular Orbital (LUMO) energy
levels by the means of Cyclic Voltammetry (CV), but also through rendering oligothiophenes syntheses more expeditiously
in comparison with the classical organic ones. This review outlines the application of electrochemistry techniques
in the synthesis of oligothiophene derivatives.
Recent Advancements in the Synthesis and Chemistry of Benzo-fused Nitrogen- and Oxygen-based Bioactive Heterocycles
Authors: Sharma Ritu , Yadav Ravi K. , Sharma Richa , Sahu Nawal K. , Jain Mukesh , Chaudhary Sandeep
Published: July 2021

Since a variety of benzo-fused nitrogen- and oxygen-based bioactive heterocyclic moieties
are present in the form of benzoxazinones, spirooxindole-based heterocyclic compounds, coumarinfused
heterocyclic compounds, and 2H-indazoles, this review article briefly describes some of the
major advancements and developments in the area of 1,4-benzoxazine-3-ones, 1,4-benzoxazin-2-
ones, spiropyrrolidine and spiropyrrolizine-based ring compounds, coumarin-fused compounds, benzopyran-
fused coumarins and a 2H-indazoles class of bioheterocycles. Thus, keeping in view the
medicinal importance of these bioactive benzo-fused heterocycles, special attention has been given to
their synthesis as well as medicinal/pharmaceutical properties in detail.
Photo Cross-linkable Biopolymers for Cornea Tissue Healing
Authors: Nozari Negar , Biazar Esmaeil , Kamalvand Mahshad , Keshel Saeed Heidari , Shirinbakhsh Shervin
Published: July 2021

:

Light can act as an effective and strong agent for the cross-linking of biomaterials and
tissues and is recognized as a safe substitute for chemical cross-linkers to modify mechanical and
physical properties and promote biocompatibility. This review focuses on the research about crosslinked
biomaterials with different radiation sources such as Laser or ultraviolet (UV) that can be applied
as scaffolds, controlled release systems,and tissue adhesives for cornea healing and tissue regeneration.
Penggunaan Limbah Sayur Pasar Dalam Pakan Crumble Dan Pengaruhnya Terhadap Penampilan Produksi Dan Mikroflora Usus Ayam Broiler
Authors: Santoso Erik Priyo , Fitasari Eka , Thiasari Nurita
Published: July 2021

Tuntutan peningkatan sumber protein hewani terutama daging unggas menuntut ketersediaan pakan yang kontinyu, salah satunya adalah pemanfaatan limbah sayur pasar. Limbah ini jumlahnya banyak setiap harinya dan masih banyak yang belum termanfaatkan bahkan cenderung menimbulkan pencemaran lingkungan. Tujuan penelitian ini adalah mencari level terbaik penggunaan limbah sayur sebagai pakan ayam broiler yang memberikan peningkatan terhadap penampilan produksi dan kondisi microflora yang baik.Â  Metode penelitian adalah menggunakan Rancangan Acak Lengkap (RAL) dengan 5 perlakuan yaitu P1 (pakan control tanpa limbah sayur), P2 (penggunaan 5% limbah sayur dalam 100% formulasi pakan), P3 (penggunaan 10% limbah sayur dalam 100% formulasi pakan), P3 (penggunaan 15% limbah sayur dalam 100% formulasi pakan), dan P4 (penggunaan 20% limbah sayur dalam 100% formulasi pakan). Parameter yang diamati terdiri dari 2 kelompok yaitu terhadap penampilan produksi dan kondisi microflora usus.Â  Hasil penelitian menghasilkan penggunaan pakan crumble ayam broiler berbasis limbah sayur memberikan pengaruh yang sangat nyata terhadap konsumsi, FCR, total TPC (p<0.01), serta peningkatan terhadap bobot badan dan jumlah bakteri asam laktat (BAL) dibandingkan dengan control. Penggunaan proporsi 15% limbah sayur memberikan peningkatan tertinggi terhadap konsumsi, pertambahan bobot badan, dan penurunan FCR, dan peningkatan terhadap BAL.
Single Nucleotide Polymorphims (snps) Identification of Inhibin Sub Unit-Î± (inha) Gene on Madura Bulls
Authors: Novianti Irida , Nugraha Chairdin Dwi , Putri Rafika Febriani , Furqon Ahmad , Septian Wike Andre , Rahayu S. , Nurgiartiningsih V. M. A. , Suyadi Suyadi
Published: July 2021

INHA gene is a gene that is suggested to have role in reproductive system. Single Nucleotide Polymorphisms (SNPs) of Madura Bulls were identified in this study. Polymerase Chain Reactions (PCR) was used to amplify INHA gene region and MEGA 7 program was utilized to align the amplified region sequences with sequence from Ensembl database. Four SNPs found in INHA and they are located at the first exon. Two SNPs were misssense mutations that causing the substitution of amino acid leucine21 by proline, and amino acid valine63 by methionine and the other two SNPs were synonymous mutation. One of the synonymous SNPs was a novel mutation. Based on those identified SNPs, they could be suggested as potential candidate markers of reproduction traits for Madura bulls. Moreover, through heterozygosity value from the observed bulls, it was indicated that the genotype was varied in population. Therefore a molecular selection program could be designed to determine the Madura superior bull.
Hubungan Antara Umur, Bobot Badan, Lingkar Skrotum Dengan Produksi Spermatozoa Sapi Peranakan Ongole
Authors: Nugraha Chairdin Dwi , Putri Rafika Febriani , Furqon Ahmad , Septian Wike Andre , Suyadi Suyadi
Published: July 2021

Sapi peranakan Ongole atau lebih dikenal dengan sapi PO merupakan salah satu ras sapi lokal yang banyak dipelihara di Indonesia. Pengembangan pada aspek reproduksi dalam pemilihan pejantan unggul menjadi sangat penting. Umur, bobot badan (BB), lingkar skrotum (LS) dan produksi semen merupakan kriteria dalam pemilihan pejantan unggul. penelitian ini bertujuan untuk mengetahui nilai korelasi antara umur, bobot badan dan lingkar skrotum terhadap total spermatozoa (TS) dan total spermatozoa motil (TSM). 11 ekor pejantan sapi PO di UPT PT & HMT Tuban dengan umur 2-8 tahun digunakan dalam penelitian ini. Total 48 ejakulasi dikoleksi selama empat minggu. Metode penelitian adalah observasional. Data dianalisis menggunakan SPSS 24 dengan metode OneWay ANOVA serta hubungan antar variabel menggunakan korelasi pearson (r). Hasil Penelitian menunjukkan bahwa umur berpengaruh nyata (p<0,05) terhadap nilai TS dan TSM. Umur, BB dan LS berkorelasi signifikan (p<0,05) terhadap TS dengan nilai masing masing secara berurutan yaitu (r=0,444), (r=0,615) dan (r=0,404). Umur, BB dan LS berkorelasi signifikan (p<0,05) terhadap TSM dengan nilai (r=0,459), (r=0,635) dan (r=0,402). Pemilihan pejantan unggul sapi PO perlu mempertimbangkan BB, umur dan LS yang tinggi sesuai Standar Nasional Indonesia.