bluuebunny/crossref_metadata_2025 huggingface dataset:
Risks of Aromatase Inhibitor-Related Cardiotoxicity in Patients with Breast Cancer in Asia
Authors: Chang Wei-Ting , Chen Po-Wei , Lin Hui-Wen , Kuo Yu-Hsuan , Lin Sheng-Hsiang , Li Yi-Heng
Published: January 2022

Background: Despite a preferred endocrine therapy for women with estrogen and progesterone receptor-positive breast cancer, aromatase inhibitors (AIs) have been reported to increase risks of cardiovascular events. Given that breast cancer patients in Asia are younger at diagnosis, it is urgent to investigate this safety concern. Methods: Through the Taiwanese National Cohort, we identified breast cancer patients initiating selective estrogen receptor modulators (SERMs) or AIs from 2010 to 2016. Outcomes includes major adverse cardio- and cerebrovascular events (MACCEs). The average follow-up duration was five years. Results: We identified 16,730 breast cancer patients treated with SERMs and 11,728 receiving AIs. The population was older and had more comorbidities in the AI group than in the SERM group. After adjusting for age, cancer stage, cancer therapies, cardiovascular drugs and comorbidities, despite similar risks of MACCEs between AI and SERM users, the risk of HF was significantly higher in patients treated with SERMs after adjusted mortality as a competing risk. When divided by the age of 50 years, despite a similar MACCEs in the younger population, MACCEs remained significantly higher in the older population who received SERMs. Conclusions: In this Asian cohort, we found that among patients of old age or with advanced cancer stage, the use of SERMs was associated with a higher risk of cardiovascular events than the use of AIs.
Chemokine Receptor-Targeted Therapies: Special Case for CCR8
Authors: Moser Bernhard
Published: January 2022

Immune checkpoint blockade inhibitors (CBIs) targeting cytotoxic T lymphocyte associated protein-4 (CTLA-4) and program death receptor-1 (PD-1) or its ligand-1 (PD-L1) have transformed the outlook of many patients with cancer. This remarkable progress has highlighted, from the translational point of view, the importance of immune cells in the control of tumor progression. There is still room for improvement, since current CBI therapies benefit a minority of patients. Moreover, interference with immune checkpoint receptors frequently causes immune related adverse events (irAEs) with life-threatening consequences in some of the patients. Immunosuppressive cells in the tumor microenvironment (TME), including intratumoral regulatory T (Treg) cells, tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs), contribute to tumor progression and correlate with a negative disease outlook. Recent reports revealed the selective expression of the chemokine receptor CCR8 on tumor Treg cells, making CCR8 a promising target in translational research. In this review, I summarize our current knowledge about the cellular distribution and function of CCR8 in physiological and pathophysiological processes. The discussion includes an assessment of how the removal of CCR8-expressing cells might affect both anti-tumor immunity as well as immune homeostasis at remote sites. Based on these considerations, CCR8 appears to be a promising novel target to be considered in future translational research.
NOX2-Induced High Glycolytic Activity Contributes to the Gain of COL5A1-Mediated Mesenchymal Phenotype in GBM
Authors: Park Youngjoon , Park Minwoo , Kim Junhyung , Ahn Juwon , Sim Jeongmin , Bang Ji-In , Heo Jinhyung , Choi Hyejeong , Cho Kyunggi , Lee Mihye , Moon Jong-Seok , Lim Jaejoon
Published: January 2022

The alteration of the cellular metabolism is a hallmark of glioma. The high glycolytic phenotype is a critical factor in the pathogenesis of high-grade glioma, including glioblastoma multiforme (GBM). GBM has been stratified into three subtypes as the proneural, mesenchymal, and classical subtypes. High glycolytic activity was found in mesenchymal GBM relative to proneural GBM. NADPH oxidase 2 (NOX2) has been linked to cellular metabolism and epithelial-mesenchymal transition (EMT) in tumors. The role of NOX2 in the regulation of the high glycolytic phenotype and the gain of the mesenchymal subtype in glioma remain unclear. Here, our results show that the levels of NOX2 were elevated in patients with GBM. NOX2 induces hexokinase 2 (HK2)-dependent high glycolytic activity in U87MG glioma cells. High levels of NOX2 are correlated with high levels of HK2 and glucose uptake in patients with GBM relative to benign glioma. Moreover, NOX2 increases the expression of mesenchymal-subtype-related genes, including COL5A1 and FN1 in U87MG glioma cells. High levels of NOX2 are correlated with high levels of COL5A1 and the accumulation of extracellular matrix (ECM) in patients with GBM relative to benign glioma. Furthermore, high levels of HK2 are correlated with high levels of COL5A1 in patients with GBM relative to benign glioma. Our results suggest that NOX2-induced high glycolytic activity contributes to the gain of the COL5A1-mediated mesenchymal phenotype in GBM.
Second Cancers in Classical Hodgkin Lymphoma and Diffuse Large B-Cell Lymphoma: A Systematic Review by the Fondazione Italiana Linfomi
Authors: Nassi Luca , De Sanctis Vitaliana , Loseto Giacomo , Gerardi Chiara , Allocati Eleonora , Ciavarella Sabino , Minoia Carla , Guarini Attilio , Bari Alessia
Published: January 2022

Background: The increase of lymphoma patient survival led to a modification of the incidence of long-term sequelae, including second malignancies (SM). Several groups have dealt with the incidence of SM, according to the primary treatment; however, a standardized approach for the early detection and screening of SM in the population of lymphoma survivors should be implemented. Methods: A systematic review was conducted by Fondazione Italiana Linfomi (FIL), in order to define the incidence of SM, the impact of modern radiotherapy on SM risk, and the usefulness of tailored follow-up and screening strategies for early diagnosis of SM. Classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL) survivors were investigated. The MEDLINE, Embase, and Cochrane Library databases were checked for relevant reports published up to January 2020. The selection process was reported according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Results: A total of 27 full-text manuscripts resulted as eligible for the analysis. The incidence of SM in cHL patients treated with ABVD was higher compared to the general population and was even higher in patients treated with intensified regimens. The risk increased over time, as well as after 10–15 years from therapy, and was augmented by radiotherapy exposure. In DLBCL, more intensive regimens (i.e., R-CHOEP or R-MegaCHOEP) vs. R-CHOP were associated with a higher SM incidence. Salvage chemotherapy and autologous stem cell transplants increased the risk of SM in both cHL and DLBCL cohorts. A lower incidence of SM, particularly of breast cancer (BC), was shown in cohorts of cHL survivors treated with reduced radiation volumes and doses (involved fields vs. extended fields), but robust trials are still lacking. Considering the advantage of a structured screening for early detection of SM, all the included studies regarded cHL survivors and screening strategy for early BC detection. Moreover, the authors discuss additional papers, to guide the early diagnosis of lung, colorectal, skin, and thyroid cancer in patients at risk due to family history, drug or RT exposure, or unhealthy lifestyles. These screening strategies all passed through patient awareness. Conclusion: A modern approach to chemotherapy and radiotherapy led to a lower risk of SM, which should be confirmed over time. Early detection of secondary cancers could be achieved through a tailored screening program, according to the individual risk profile.
Cost-Effectiveness Analysis of Axicabtagene Ciloleucel vs. Tisagenlecleucel for the Management of Relapsed/Refractory Diffuse Large B-Cell Lymphoma in Spain
Authors: Bastos-Oreiro Mariana , de las Heras Ana , Presa María , Casado Miguel A. , Pardo Carlos , Martín-Escudero Victoria , Sureda Anna
Published: January 2022

The study aimed to assess the cost-effectiveness of axicabtagene ciloleucel (axi-cel) vs. tisagenlecleucel (tisa-cel) for the treatment of relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) after ≥2 lines of systemic therapy in Spain. A lifetime partitioned survival mixture cure model, which comprises pre-progression, post-progression, and death health states, was used to estimate the accumulated costs and outcomes in terms of life years gained (LYG) and quality-adjusted life years (QALY). A matching-adjusted indirect comparison was used to reweight patient-level data from ZUMA-1, the pivotal clinical trial for axi-cel, to aggregate-level data from the pivotal tisa-cel trial, JULIET. The analysis was performed from the National Health System perspective, thus only direct costs were included. Sensitivity analyses (SA) were performed. Axi-cel yielded 2.74 incremental LYG and 2.31 additional QALY gained per patient compared to tisa-cel. Total incremental lifetime costs for axi-cel versus tisa-cel were €30,135/patient. The incremental cost-effectiveness ratio of axi-cel versus tisa-cel resulted in €10,999/LYG and the incremental cost-utility ratio in €13,049/QALY gained. SA proved robustness of the results. Considering the frequently assumed willingness-to-pay thresholds in Spain (€22,000/QALY and €60,000/QALY), axi-cel is a cost-effective treatment vs. tisa-cel for adult patients with R/R DLBCL in Spain.
The Effect of Grapevine Variety and Wine Region on the Primer Parameters of Wine Based on 1H NMR-Spectroscopy and Machine Learning Methods
Authors: Nyitrainé Sárdy Ágnes Diána , Ladányi Márta , Varga Zsuzsanna , Szövényi Áron Pál , Matolcsi Réka
Published: January 2022

Nuclear magnetic resonance (NMR) spectroscopy is an innovative method for wine analysis. Every grapevine variety has a unique structural formula, which can be considered as the genetic fingerprint of the plant. This specificity appears in the composition of the final product (wine). In the present study, the originality of Hungarian wines was investigated with 1H NMR-spectroscopy considering 861 wine samples of four varieties (Cabernet Sauvignon, Blaufränkisch, Merlot, and Pinot Noir) that were collected from two wine regions (Villány, Eger) in 2015 and 2016. The aim of our analysis was to classify these varieties and region and to select the most important traits from the observed 22 ones (alcohols, sugars, acids, decomposition products, biogene amines, polyphenols, fermentation compounds, etc.) in order to detect their effect in the identification. From the tested four classification methods—linear discriminant analysis (LDA), neural networks (NN), support vector machines (SVM), and random forest (RF)—the last two were the most successful according to their accuracy. Based on 1000 runs for each, we report the classification results and show that NMR analysis completed with machine learning methods such as SVM or RF might be a successfully applicable approach for wine identification.
Pulmonary Metastasizing Low-Grade Endometrial Stromal Sarcoma: Case Report and Review of Diagnostic Pitfalls
Authors: Kim Geon Woo , Baek Sun Kyung , Han Jae Joon , Kim Hong Jun , Sung Ji-Youn , Maeng Chi Hoon
Published: January 2022

Pulmonary manifestations of benign metastasizing leiomyoma (BML) usually include multiple well-defined, round, bilateral nodules. Low-grade endometrial stromal sarcoma (LG-ESS) is a rare uterine tumor. A 70-year-old woman visited the clinic complaining of acute cough and dyspnea in April 2017. Chest computed tomography (CT) revealed pneumothorax and multiple pulmonary nodules. She had a history of hysterectomy for uterine leiomyoma 23 years ago. Biopsy revealed that the pulmonary masses were consistent with BML. However, the patient had two subsequent episodes of acute, recurrent respiratory distress, accompanied by massive pleural effusions and hydropneumothorax over the next two years. A chest CT performed for acute dyspnea revealed large and multiple hydropneumothoraces. The size and distribution of pulmonary masses were aggravated along with cystic changes and bilateral pleural effusions. Given this aggressive feature, additional immunohistochemical findings and gynecologic pathologist review confirmed the correct diagnosis to be LG-ESS. After initiating anti-estrogen therapy, the patient achieved a partial response, without recurrence of symptoms, for 28 months. Metastatic LG-ESS responds well to anti-hormonal therapy. If the clinical pattern of a disease is different than expected, the possibility of a correction in the diagnosis should be considered.
On the Thermodynamics of the q-Particles
Authors: Ciolli Fabio , Fidaleo Francesco
Published: January 2022

Since the grand partition function Zq for the so-called q-particles (i.e., quons), q∈(−1,1), cannot be computed by using the standard 2nd quantisation technique involving the full Fock space construction for q=0, and its q-deformations for the remaining cases, we determine such grand partition functions in order to obtain the natural generalisation of the Plank distribution to q∈[−1,1]. We also note the (non) surprising fact that the right grand partition function concerning the Boltzmann case (i.e., q=0) can be easily obtained by using the full Fock space 2nd quantisation, by considering the appropriate correction by the Gibbs factor 1/n! in the n term of the power series expansion with respect to the fugacity z. As an application, we briefly discuss the equations of the state for a gas of free quons or the condensation phenomenon into the ground state, also occurring for the Bose-like quons q∈(0,1).
Composite Multivariate Multi-Scale Permutation Entropy and Laplacian Score Based Fault Diagnosis of Rolling Bearing
Authors: Ying Wanming , Tong Jinyu , Dong Zhilin , Pan Haiyang , Liu Qingyun , Zheng Jinde
Published: January 2022

As a powerful tool for measuring complexity and randomness, multivariate multi-scale permutation entropy (MMPE) has been widely applied to the feature representation and extraction of multi-channel signals. However, MMPE still has some intrinsic shortcomings that exist in the coarse-grained procedure, and it lacks the precise estimation of entropy value. To address these issues, in this paper a novel non-linear dynamic method named composite multivariate multi-scale permutation entropy (CMMPE) is proposed, for optimizing insufficient coarse-grained process in MMPE, and thus to avoid the loss of information. The simulated signals are used to verify the validity of CMMPE by comparing it with the often-used MMPE method. An intelligent fault diagnosis method is then put forward on the basis of CMMPE, Laplacian score (LS), and bat optimization algorithm-based support vector machine (BA-SVM). Finally, the proposed fault diagnosis method is utilized to analyze the test data of rolling bearings and is then compared with the MMPE, multivariate multi-scale multiscale entropy (MMFE), and multi-scale permutation entropy (MPE) based fault diagnosis methods. The results indicate that the proposed fault diagnosis method of rolling bearing can achieve effective identification of fault categories and is superior to comparative methods.
A Review of Bayesian Hypothesis Testing and Its Practical Implementations
Authors: Wei Zhengxiao , Yang Aijun , Rocha Leno , Miranda Michelle F. , Nathoo Farouk S.
Published: January 2022

We discuss hypothesis testing and compare different theories in light of observed or experimental data as fundamental endeavors in the sciences. Issues associated with the p-value approach and null hypothesis significance testing are reviewed, and the Bayesian alternative based on the Bayes factor is introduced, along with a review of computational methods and sensitivity related to prior distributions. We demonstrate how Bayesian testing can be practically implemented in several examples, such as the t-test, two-sample comparisons, linear mixed models, and Poisson mixed models by using existing software. Caveats and potential problems associated with Bayesian testing are also discussed. We aim to inform researchers in the many fields where Bayesian testing is not in common use of a well-developed alternative to null hypothesis significance testing and to demonstrate its standard implementation.
Modeling and Design Optimization of Energy Transfer Rate for Hybrid Energy Storage System in Electromagnetic Launch
Authors: Ma Tao , Lu Junyong , Zhang Xiao , Zhu Bofeng , Wu Wenxuan , Long Xinlin
Published: January 2022

The battery-pulse capacitor-based hybrid energy storage system has the advantage of high-energy density and high-power density. However, to achieve a higher firing rate of the electromagnetic launch, a shorter charging time of the pulse capacitor from the battery is needed. A new optimization model by formulating the charging time problem as a constrained optimization problem is presented. Unlike existing algorithms, the proposed model can find the globally optimal solution. The circuit parameters are optimized through the Enumeration algorithm to minimize the total charging time of the pulse capacitors from batteries. The simulation results show that the charging time of the proposed algorithm is shorter than the compared methods. Furthermore, a better solution could be obtained by canceling the constraint on the first peak of the charging current of the compared methods, which makes the circuit design more flexible for the hybrid energy storage system in the electromagnetic launch.
Transforming a Historic Public Office Building in the Centre of Rome into nZEB: Limits and Potentials
Authors: Cumo Fabrizio , Nardecchia Fabio , Agostinelli Sofia , Rosa Flavio
Published: January 2022

According to the last census of 2019, about two million Italian buildings are more than 100 years old. Building energy retrofitting involves a diverse mix of influencing factors, depending on history, intended use, and construction techniques. This paper aims to assess the energy needs of a historic building by evaluating the variability of climatic conditions and internal loads, as well as the thermal capacity of the building envelope. The energy analysis was conducted using dynamic simulation systems (TRNSYS). The purpose of the study is to provide an analysis of the current energy conditions of the building to identify the main critical issues and suggest the most suitable interventions to be implemented. All the transformations were conducted to meet the nZEB requirements and evaluate technical and economic feasibility, compatibility with architectural and landscape constraints, and large-scale replicability. Specifically, to reach the proposed targets, a 36 kWp PV system was implemented for an area of 210 m2, in addition to the Air Handling Unit (AHU) already present. The profit index is above the unit, and it yields a time range between three and four years. Therefore, fully respecting the energy performance parameters required by the Italian legislation, the study demonstrated the unattainability of the nZEB class for a listed building.
Development of a Low-Depth Modular GHX through a Real-Scale Experiment
Authors: Kim Kwonye , Bae Sangmu , Nam Yujin , Lee Euyjoon , Entchev Evgueniy
Published: January 2022

The global energy sector is aiming to rapidly transform energy systems into those less dependent on fossil fuels to reduce their harmful effects on the climate. Although ground source heat pump (GSHP) systems are more efficient than conventional air-source heat pump (ASHP) systems, the high initial investment cost, particularly for a vertical closed-loop type ground heat exchanger (GHX), makes it difficult to incorporate them into small buildings. This paper proposes a low-depth modular GHX for reducing cost and improving the workability of GSHPs. A modular GHX is a cubical structure comprising tubes and buried using an excavator at a depth 4 m below the ground surface. This GHX is manufactured at a factory, carried by a small truck, and then installed by a small lift or a backhoe such that it can be installed in small buildings or narrow spaces at low depths underground. In this research, the performance and feasibility analyses of modular and vertical GHXs were conducted via a real-scale experiment. The results demonstrate that the modular GHX influences the workability of GSHPs by 91% during the heating period and 70% during the cooling period. In contrast to the conventional HVAC, the modular and vertical GHXs could recover the initial investment costs in 4 years and 10 years, respectively.
A New Graphitic Nitride and Reduced Graphene Oxide-Based Sulfur Cathode for High-Capacity Lithium-Sulfur Cells
Authors: Suzanowicz Artur M. , Lee Youngjin , Lin Hao , Marques Otavio J. J. , Segre Carlo U. , Mandal Braja K.
Published: January 2022

Lithium-sulfur (Li-S) batteries can provide at least three times higher energy density than lithium-ion (Li-Ion) batteries. However, Li-S batteries suffer from a phenomenon called the polysulfide shuttle (PSS) that prevents the commercialization of these batteries. The PSS has several undesirable effects, such as depletion of active materials from the cathode, deleterious reactions between the lithium anode and electrolyte soluble lithium polysulfides, resulting in unfavorable coulombic efficiency, and poor cycle life of the battery. In this study, a new sulfur cathode composed of graphitic nitride as the polysulfide absorbing material and reduced graphene oxide as the conductive carbon host has been synthesized to rectify the problems associated with the PSS effect. This composite cathode design effectively retains lithium polysulfide intermediates within the cathode structure. The S@RGO/GN cathode displayed excellent capacity retention compared to similar RGO-based sulfur cathodes published by other groups by delivering an initial specific capacity of 1415 mA h g−1 at 0.2 C. In addition, the long-term cycling stability was outstanding (capacity decay at the rate of only 0.2% per cycle after 150 cycles).
Protection of Future Electricity Systems
Authors: Dyśko Adam , Tzelepis Dimitrios
Published: January 2022

The electrical energy industry is undergoing dramatic changes; the massive deployment of renewables, an increasing share of DC networks at transmission and distribution levels, and at the same time, a continuing reduction in conventional synchronous generation, all contribute to a situation where a variety of technical and economic challenges emerge [...]
Pollutant Emissions during Oxy-Fuel Combustion of Biomass in a Bench Scale CFB Combustor
Authors: Kosowska-Golachowska Monika , Luckos Adam , Kijo-Kleczkowska Agnieszka
Published: January 2022

Nowadays oxy-fuel combustion of coal and biomass is the most promising option for the reduction of CO2 emissions from power plants. In this paper, emissions of NOx (NO, NO2, N2O and their precursors, such as NH3 and HCN), SO2 and CO during conventional and oxy-fuel combustion of three kinds of biomass (agro, woody and energy crop) and a reference coal are presented and discussed. Combustion tests were conducted at 850 °C in the laboratory-scale circulating fluidized bed (CFB) reactor in air and O2/CO2 atmospheres. A FTIR spectrometer was used to measure instantaneous concentrations of all pollutants in the flue gas. Emissions of SO2, N2O and CO for the combustion of biomass in all atmospheres were lower than those for the combustion of reference coal. It was found that oxidation of nitrogen species released with volatile matter was responsible for high emissions of NOx during combustion of biomass fuels in air and mixtures of O2 and CO2. The lowest NO emissions for tested fuels were detected in oxy-21 atmosphere (21% O2/70% CO2). Oxy-combustion of biomass in O2/CO2 mixtures at 30% and 40% O2 caused a decrease in emissions of N2O and CO while NO and SO2 emissions increased. The results of this study show that the tested biomass fuels are ideal renewable energy resources both in conventional and oxy-fuel conditions with a minor potential for environmental pollution.
Optimizing Device Structure of PTB7-Th:PNDI-T10 Bulk Heterojunction Polymer Solar Cells by Enhancing Optical Absorption
Authors: Setsoafia Daniel Dodzi Yao , Ram Kiran Sreedhar , Rad Hooman Mehdizadeh , Ompong David , Elumalai Naveen Kumar , Singh Jai
Published: January 2022

Using the optical transfer matrix method, we optimized the layered structure of a conventional and an inverted BHJ OSC with the active layer made of blended PTB7-Th:PNDI-T10 by maximizing the optical absorption and, hence, the JSC. The maximum JSC thus obtained from the optimised structure of the inverted OSC was 139 Am−2 and that of the conventional OSC was 135 Am−2. Simulation of the electric field distribution in both inverted and conventional OSCs showed that the formation of a single CIP was obtained in the active layer of thickness 105 nm in both OSCs. As the light incidents from the ITO side, it was found that excitons were generated more closely to ITO electrode, which favors the efficient charge transport and collection at the opposite electrodes in the inverted OSC, which produces higher JSC.
Seasonal Energy Storage with Power-to-Methane Technology
Authors: Imre Attila R.
Published: January 2022

To have a sustainable society, the need to use renewable sources to produce electricity is inevitable [...]
Modelling of the Electric Energy Storage Process in a PCM Battery
Authors: Karbowniczak Anna , Latała Hubert , Nęcka Krzysztof , Kurpaska Sławomir , Bergel Tomasz
Published: January 2022

The essence of the research was the modeling of a real electric energy storage system in a phase change battery operating in a foil tunnel. The scope of the work covered the construction of two partial models, i.e., energy storage in the PCM accumulator and heat losses in the PCM accumulator. Their construction was based on modeling methods selected on the basis of a literature review and previous analyses, i.e., artificial neural networks, random forest, enhanced regression trees, MARS plines, standard multiple regression, standard regression trees, exhaustive for regression trees. Based on the analysis of the error values, the models of the best quality were selected. The final result of this study was the construction of such a model of the process of storing electricity in a PCM battery, characterized by the mean absolute percentage error forecast error of 1–2%. The achievement of this goal was possible thanks to the use of the artificial neural networks model for which the input variables were the amount of energy supplied to the accumulator and the temperature of the heat storage medium.
Feasibility of Solar Grid-Based Industrial Virtual Power Plant for Optimal Energy Scheduling: A Case of Indian Power Sector
Authors: Sharma Harpreet , Mishra Sachin , Dhillon Javed , Sharma Naveen Kumar , Bajaj Mohit , Tariq Rizwan , Rehman Ateeq Ur , Shafiq Muhammad , Hamam Habib
Published: January 2022

The increased popularity of small-scale DER has replaced the well-established concept of conventional generating plants around the world. In the present energy scenario, a significant share of energy production now comes from the grid integrated DERs installed at various consumer premises. These DERs are being renewable-based generates only intermittent power, which in turn makes the scheduling of electrical dispatch a tough task. The Virtual Power Plant (VPP) is a potential solution to this challenge, which coordinates and aggregates the DERs generation into a single controllable profile. In this paper, a modified PSO-based multi-objective optimization is proposed for the VPP scheduling in distribution network applications such as energy cost minimization, peak shaving, and reliability improvement. For feasibility analysis of the VPP, a case study of state power utility is taken, which includes a 90 bus industrial feeder with grid integrated PVs as DER. The optimized results are computed in both grid-connected and autonomous mode reveal that the operating cost, peak demand, and EENS are declined by 31.70%, 23.59%, and 62.30% respectively. The overall results obtained are compared by the results obtained from other well-established optimization techniques and it is found that the proposed technique is comparatively more cost-effective than others.
Time Series Forecasting for Energy Consumption
Authors: Pegalajar M. C. , Ruiz L. G. B.
Published: January 2022

Introduction In the last few years, there has been considerable progress in time series forecasting algorithms, which are becoming more and more accurate, and their applications are numerous and varied [...]
Optimized Design of Laminated Busbar for Large-Capacity Back-to-Back Converters
Authors: Xu Mingxia , Wang Ninghui , Wang Zhipeng
Published: January 2022

As a key component of a large-capacity converter, the laminated busbar can improve the reliability, integration and power density of the converter and has great advantages in reducing the parasitic inductance of the switching loop. The laminated busbar suitable for a high-capacity back-to-back converter has a complex structure, and couple with each side converter. It has been challenging to optimize the equivalent inductance by using the traditional single-converter busbar design method. In this paper, the coupling inductance model of the back-to-back converter is established, and the relationship between the voltage stress of the switch tube and the stray inductance is analyzed in detail. Based on this, the design principle of the laminated busbar is proposed, and an optimized design structure of the laminated busbar suitable for the large-capacity back-to-back converter is given. Finally, the results were effectively verified by simulation analysis and a 180 kW integrated intermediate frequency auxiliary power converter.
Comparison of Selected Technologies to Improve the Quality of Exhaust Gases from Landfill Gas Combustion
Authors: Gaze Błażej , Knutel Bernard , Zając Krzysztof , Jajczyk Mateusz , Bukowski Przemysław
Published: January 2022

This paper presents the results of research on exhaust gases from landfill gas combustion. The measurements were carried out in a reclaimed landfill in Kiełcz (a passive degassing system based on gas flare). The research concerned the effects of selected exhaust gas purification technologies (platinum catalyzer on a ceramic carrier, molecular sieve, copper(II) oxide) for the quality of exhaust gases, and their particulate matter content. This paper aims to indicate which catalytic systems are most suitable for this gas type and their most efficient positioning in the flue gas duct. Due to increasingly stringent emission standards, the outcomes presented in this article could be helpful for landfill owners who wish to avoid paying fines for not complying with applicable limits. The measurements were carried out using a flue gas analyser, a particulate matter analyser fitted with a probe, and four thermocouples connected with the data recorder. The research outcomes determined the percentage reduction of pollutant emissions into the atmosphere (CO, NOx, and particulate matter) using catalysts. The potential benefits of using catalysts in landfill gas combustion systems due to their operating temperature ranges are discussed.
The Modeling of the LC Divergence Oscillation Circuit of a Superconducting DC Circuit Breaker Using PSCAD/EMTDC
Authors: Park Sang-Yong , Kim Geon-Woong , Jeong Ji-Sol , Choi Hyo-Sang
Published: January 2022

We proposed a superconducting DC circuit breaker that can reliably cut off the fault currents in preparation for the DC system. It consists of a superconducting element and a mechanical DC circuit breaker. The mechanical DC circuit breaker is connected in parallel with a mechanical high-speed switch, an LC divergence oscillation circuit, and a surge arrester. This provides stable cutoff operation due to the fault-current-limiting operation of the superconducting element and the artificial current zero point of the mechanical DC circuit breaker. In this paper, the operating principle of the LC divergence oscillation circuit that creates an artificial current zero point was reviewed based on the theory. We used experimental data to model the time constant of the initial fault current, the arc model generated by the mechanical high-speed switch, and the experimental equipment. As a result, the LC divergence oscillation circuit was confirmed in the simulation, and simulation modeling was reviewed based on the theoretical principle of generation.
cDNA Characterization and Expression of Selenium-Dependent CqGPx3 Isoforms in the Crayfish Cherax quadricarinatus under High Temperature and Hypoxia
Authors: Hernández-Aguirre Laura E. , Fuentes-Sidas Yazmin I. , Rivera-Rangel Lizandro R. , Gutiérrez-Méndez Néstor , Yepiz-Plascencia Gloria , Chávez-Flores David , Zavala-Díaz de la Serna Francisco J. , Peralta-Pérez María del R. , García-Triana Antonio
Published: January 2022

Glutathione peroxidase 3 (GPx3) is the only extracellular selenoprotein (Sel) that enzymatically reduces H2O2 to H2O and O2. Two GPx3 (CqGPx3) cDNAs were characterized from crayfish Cherax quadricarinatus. The nerve cord CqGPx3a isoform encodes for a preprotein containing an N-terminal signal peptide of 32 amino acid residues, with the mature Sel region of 192 residues and a dispensable phosphorylation domain of 36 residues. In contrast, the pereiopods CqGPx3b codes for a precursor protein with 19 residues in the N-terminal signal peptide, then the mature 184 amino acid residues protein and finally a Pro-rich peptide of 42 residues. CqGPx3 are expressed in cerebral ganglia, pereiopods and nerve cord. CqGPx3a is expressed mainly in cerebral ganglia, antennulae and nerve cord, while CqGPx3b was detected mainly in pereiopods. CqGPx3a expression increases with high temperature and hypoxia; meanwhile, CqGPx3b is not affected. We report the presence and differential expression of GPx3 isoforms in crustacean tissues in normal conditions and under stress for high temperature and hypoxia. The two isoforms are tissue specific and condition specific, which could indicate an important role of CqGPx3a in the central nervous system and CqGPx3b in exposed tissues, both involved in different responses to environmental stressors.
Successful Treatment of Bacteremia and Ventilator-Associated Pneumonia Caused by KPC/OXA-48-like Klebsiella pneumoniae Co-Producer with a Continuous Infusion of High-Dose Meropenem Plus Fosfomycin Guided by Real-Time Therapeutic Drug Monitoring
Authors: Cojutti Pier Giorgio , Fornaro Giacomo , Gatti Milo , Rinaldi Matteo , Gaibani Paolo , Giannella Maddalena , Pea Federico , Viale Pierluigi
Published: January 2022

Bacteremia and ventilator-associated pneumonia due to a pan-resistant Klebsiella pneumoniae strain co-producing KPC and OXA-48 carbapenemases was successfully treated in a COVID-19 critically ill patient with a combination therapy of a high-dose continuous infusion of meropenem (up to 3 g every 6 h, daily) plus fosfomycin (up to 24 g/daily) that was guided by real-time therapeutic drug monitoring. Clinical pharmacological advice was helpful in maximizing, over time, the pharmacodynamic target attainment of both antibiotics.
The Psychological Structure of Loneliness
Authors: Seemann Axel
Published: January 2022

Despite the current surge of interest in loneliness, its health consequences, and possible remedies, the concept itself remains poorly understood. This paper seeks to contribute to a more fully worked out account of what loneliness consists in. It does this by stressing that loneliness always has an experiential component and by introducing a simple psychological structure to analyze the experience. On this basis, it suggests that we can distinguish between three ways of thinking about the phenomenal dimension of loneliness. There are objectivist views that seek to understand loneliness by a description of its intentional object, subjectivist views that consider its holistic relation to other aspects of the sufferer’s psyche, and embodied and enacted views that focus on the relation between the lonely person’s mental life and her social environment. The aim is not to adjudicate between these views or to suggest that they are mutually exclusive. Rather, this paper recommends a pluralistic framework on which all three approaches have something to contribute to a fuller understanding of the condition and may be of use in devising measures aimed at improving sufferers’ health.
Influential Women in the Field of Neurological Rehabilitation: A Literature Review
Authors: Cano-de-la-Cuerda Roberto
Published: January 2022

Background: Medicine requires the brightest minds, regardless of gender. Women working in the health sciences have time and again demonstrated the value of their technical training, communication skills, emotional support, and ability to provide understandable explanations to their patients. The objective of this work was to carry out a historical review of the main female authors linked to classic sensorimotor neurorehabilitation techniques throughout the nineteenth and twentieth centuries, as well as female authors linked to eponymous tests or assessments, exposing their scientific trajectory and main contributions to the field of neurological rehabilitation. A literature review was conducted. The databases of Physiotherapy Evidence Database (PEDro), Scopus, CINAHL Medical Science, Medline through EBSCO and PubMed were used to obtain the biographical information of each author, searches of papers were limited until August 2021 in English and Spanish languages. Seventeen female authors were identified who linked to the main rehabilitation techniques or approaches described for neurological rehabilitation and for scales or tests with an eponymous origin as an example of female contribution on neurorehabilitation. Biographical information based on the computerized search in the electronic databases showed 57 potentially relevant articles. Of those articles, 43 were subsequently excluded. Fourteen articles were used to show their contribution to neurorehabilitation. This paper demonstrates the influential role of women in the history of sensorimotor neurorehabilitation throughout the nineteenth and twentieth centuries, linked to the methods, techniques, concepts, or approaches used in physical therapy or occupational therapy.
A Community Outbreak of Legionnaires’ Disease with Two Strains of L. pneumophila Serogroup 1 Linked to an Aquatic Therapy Centre
Authors: Rousseau Cyril , Ginevra Christophe , Simac Leslie , Fiard Noel , Vilhes Karine , Ranc Anne-Gaëlle , Jarraud Sophie , Gornes Hervé , Mouly Damien , Campese Christine
Published: January 2022

An outbreak of Legionnaires’ disease affected 18 people in Montpellier, a town of the south of France, between December 2016 and July 2017. All cases were diagnosed by a positive urinary antigen test. No deaths were reported. Epidemiological, environmental and genomic investigations (nested Sequence-Based Typing (nSBT) and whole genome sequencing) were undertaken. For the cases for which we had information, four had a new isolate (ST2471), one had a different new isolate (ST2470), one had a genomic pattern compatible with the ST2471 identified by nSBT (flaA = 3), and one had a genomic pattern not compatible with two previous identified STs (pilE = 6). The analysis conducted on the pool of an aquatic therapy center revealed seven isolates of Legionella pneumophila. Whole genome analysis confirmed the link between the environmental and clinical isolates for both ST2470 and ST2471. As the outbreak occurred slowly, with several weeks between new cases, it was not possible to immediately identify a common source. The sixth case was the first to report having aquatic therapy care. Of the 18 cases, eight had attended the aquatic therapy center and the other 10 were inhabitants who lived, worked or walked close to the center. The main cause for this outbreak was the lack of facility maintenance. This investigation highlights the risk to public health of aquatic therapy centers for users and nearby populations, and emphasizes the need for risk reduction measures with specific guidelines to improve health and safety in aquatic facilities.
Micronutrient Deficiency as a Confounder in Ascertaining the Role of Obesity in Severe COVID-19 Infection
Authors: Chu Brian A. , Surampudi Vijaya , Li Zhaoping , Harris Christina , Seeman Teresa , Norris Keith C. , Vijayan Tara
Published: January 2022

Food insecurity in the United States has been exacerbated due to the socioeconomic strain of the coronavirus disease 2019 (COVID-19) pandemic. Populations experiencing poverty and, as a consequence, food insecurity in the United States are disproportionately affected by obesity, which was identified early in the pandemic as a major risk factor for increased susceptibility to COVID-19 infection and mortality. Given the focus on obesity and its role in immune dysregulation, it is also important to note the role of micronutrient deficiency, another sequalae of food insecurity. Micronutrients play an important role in the ability of the immune system to mount an appropriate response. Moreover, OBESE individuals are more likely to be micronutrient deficient. This review will explore the role of micronutrients, vitamin A, vitamin D, vitamin C, and zinc in respiratory immunity and COVID-19 and how micronutrient deficiency may be a possible confounder in obesity’s association with severe outcomes. By illuminating the role of micronutrients in COVID-19, this paper expands the discussion from food insecurity and obesity to include micronutrient deficiency and how all of these interact in respiratory illnesses such as COVID-19.
Attachment- and Relationship-Based Interventions during NICU Hospitalization for Families with Preterm/Low-Birth Weight Infants: A Systematic Review of RCT Data
Authors: Kim Soo-Yeon , Kim Ah Rim
Published: January 2022

This study conducts a systematic review and meta-analysis of the randomized-controlled clinical trials (RCTs) of attachment- and relationship-based interventions in the NICU. A systematic search of the PubMed, MEDLINE, Embase (OVID), PsycINFO, and CINAHL databases and the Cochrane Database of Systematic Reviews was conducted in February 2021. Of the 32,904 studies examined, 15 were identified as relevant, and 10 RCTs were eligible for meta-analysis. Cochrane’s risk of bias tool was used to assess the quality of the trial reporting. Interventions were categorized as (1) parent–infant interactions, (2) parent education, and/or (3) support through qualitative synthesis. The attachment- or relationship-based intervention was effective in relieving maternal traumatic stress, maternal depression, infant weight growth, and infant development. Subgroup analyses suggested that interventions significantly improved sub-domains of mothers’ and children’s interactive behavior. Tailored, staged interventions may contribute to better health outcomes in preterm infants and their families.
Mental Health and Wellbeing in Young People in the UK during Lockdown (COVID-19)
Authors: Owens Matthew , Townsend Ellen , Hall Eleanor , Bhatia Tanisha , Fitzgibbon Rosie , Miller-Lakin Francesca
Published: January 2022

This study aimed to assess the levels of mental wellbeing and potential for clinical need in a sample of UK university students aged 18–25 during the COVID-19 pandemic. We also tested the dose-response relationship between the severity of lockdown restrictions and mental wellbeing. We carried out a prospective shortitudinal study (one month between baseline and follow up) during the pandemic to do this and included 389 young people. We measured a range of facets of mental wellbeing, including depression, depressogenic cognition (rumination), wellbeing, stress and sleep disturbance. Our primary outcome was ‘probable depression’ as indexed by a score of ≥10 on the patient health questionnaire (PHQ-8). The prevalence of probable depression was significantly higher than pre-pandemic levels (55%) and did not decrease significantly over time (52%). Higher levels of lockdown severity were prospectively associated with higher levels of depressive symptoms. Nearly all students had at least one mental wellbeing concern at either time point (97%). The evidence suggests that lockdown has caused a wellbeing crisis in young people. The associated long-term mental, social, educational, personal and societal costs are as yet unknown but should be tracked using further longitudinal studies.
The Effects of Non-Pharmaceutical Interventions on COVID-19 Epidemic Growth Rate during Pre- and Post-Vaccination Period in Asian Countries
Authors: Huy Le Duc , Nguyen Nhi Thi Hong , Phuc Phan Thanh , Huang Chung-Chien
Published: January 2022

There is little knowledge about how the influence of non-pharmaceutical interventions (NPIs) reduces the COVID-19 infection rate during the period of vaccine rollout. This study aimed to examine the effectiveness of NPIs on decreasing the epidemic growth of COVID-19 between before and after the vaccine rollout period among Asian countries. Our ecological study included observations from 30 Asian countries over the 20 weeks of the pre- and post-vaccination period. Data were extracted from the Oxford COVID-19 Government Response Tracker and other open databases. Longitudinal analysis was utilized to evaluate the impacts of public health responses and vaccines. The facial covering policy was the most effective intervention in the pre-vaccination period, followed by border control and testing policies. In the post-vaccination period, restrictions on gatherings and public transport closure both play a key role in reducing the epidemic growth rate. Vaccine coverage of 1–5%, 5–10%, 10–30%, and over 30% of the population was linked with an average reduction of 0.12%, 0.32%, 0.31%, and 0.59%, respectively. Our findings support the evidence that besides the vaccine increasingly contributing to pandemic control, the implementation of NPIs also plays a key role.
Determinants of Hypertension amongst Rice Farmers in West Java, Indonesia
Authors: Prihartono Nurhayati Adnan , Fitria Laila , Ramdhan Doni Hikmat , Fitriyani Fitriyani , Fauzia Sifa , Woskie Susan
Published: January 2022

The hypertension rate in Indonesia has increased significantly in the past five years, but there is limited information about the hypertension risk of farmers. Our study assesses the prevalence of hypertension in this population and examines the proportional risk of various work environment and lifestyle factors among farmers. A cross-sectional study was conducted in high and low heat stress agriculture areas of West Java, Indonesia. There were 354 male farmers aged 25 to 73 years old who participated in the study. We measured blood pressure and used a questionnaire on self-reported use of anti-hypertension drugs or diagnosis by a medical professional to define hypertension. We assessed occupational factors including farming methods, heat stress and pesticide use, and personal factors including obesity, food intake, smoking status, alcohol consumption. Multivariate analysis was used to evaluate factors potentially associated with prevalence of hypertension. Forty-six percent of farmers experience hypertension. Farming in a location with higher heat stress (WBGT) was significantly associated with increased risk of hypertension (adjusted prevalence ratio (aPR) 1.41, 95% confidence interval (CI) 1.01, 1.95). Farmers who used pesticide sprayers had an increased risk of hypertension (aPR 1.90, 95% CI 0.93, 3.87). No personal/lifestyle characteristics were significantly associated with hypertension, although ever smoking and ever consuming alcohol had an increased prevalence of hypertension. This study shows the importance of work environmental factors in the prevalence of hypertension and the necessity of public health education, identification and treatment of this “silent killer” among Indonesian farmers.