EVALUATON OF INFLAMMATION WITH CRP, IL-1, PRO-BNP, LEPTIN AND PETRAXIN -3 LEVELS IN OBESITY-RELATED HYPERTENSION
Authors: Karakuş Gürkan , Karakurt Cemşit , Elkıran Özlem , Öncül Mehmet , Maraş Serdar Akın , Tabel Yılmaz , Çamtosun Emine , Taşkapan Çağatay , Bağ Harika Gözde Gözükara 
Published: August 2024

Purpose

The aim of study is to determine the relationship between the inflammation and the severity of hypertension with the inflammation biomarkers; CRP, IL-1, proBNP, leptin, PTX-3 levels in children with obesity-related hypertension.

Material and Methods

In our study, thirty patients (20 girls, 10 boys) who were admitted to İnönü University Turgut Özal Tıp Merkezi Department of Pediatrics between 2021-2022; between the ages of 2-17 and who were followed up in Pediatric Endocrinology, Pediatric Nephrology and Pediatric Cardiology clinics for obesity-related hypertension and 30 healthy children (22 girls, 8 boys) in the same age group were included. Clinical and demographic characteristics of all children; Age, gender, anthropometric measurements, blood pressure, 24-hour ambulatory blood pressure measurements echocardiographic findings were recorded. Left ventricular systolic and diastolic diameters, volumes and wall thickness measured by echocardiography and proportioned to body surface area. After the echocardiographic evaluation, a total of 10 cc blood was drawn from the individuals and patients in the control group and IL-1, CRP, Leptin, Pro-BNP, PTX-3 levels were measured. Statistical analysis was performed using SPSS (Statistical Program in Social Sciences) 22.0 software program

Results

Systolic blood pressure, diastolic blood pressure, height, weight, body mass index were statistically significantly higher in the patient group. On echocardiographic evaluation, interventricular diastolic diameter (IVSd), left ventricular diastolic diameter (LVIDd), left ventricular posterior wall diastolic (LVPWd), interventricular systolic diameter (IVSs), left ventricular systolic diameter (LVIDs) and left ventricular diastolic diameter (LVIDd), left ventricular posterior wall systolic diameter (LVPWs) were statistically significantly higher in the patient group. LVs mass values, systolic blood pressure, diastolic blood pressure, height, weight, body mass index, IVSd, LVIDd, LVPWd, IVSs, LVIDs, LVPWs, LVs massvalues were statistically significantly higher in the patient group. In our study, when the inflammation variables in the patient and control groups were compared, leptin and CRP levels were found significantly higher in the obesity group (p:0,041). We found that there was a moderate positive correlation between leptin and systolic blood pressure in healthy children, moderately strong correlations between Pro-BNP and systolic blood pressure in the negative corelation, and a weak positive correlation between leptin and diastolic blood pressure in obesity group. When the correlations between inflammation parameters and blood pressure findings were examined in our study, positive and moderate (p:0,019 r:0,425) correlation was found between leptin and systolic blood pressure in healthy children, while negative moderate (p:0,001 r:-0,566) correlation between Pro-BNP and systolic blood pressure and positive weak correlation between leptin and diastolic blood pressure (p:0,036 r:0,384) were found in obese and hypertensive children. Leptin, systolic blood pressure, diastolic blood pressure, height, weight and body mass index, IVSd, LVIDd, LVPWd, IVSs, LVIDs, LVPWs and LVs mass values were found to be statistically significantly high in obese patients who were required anti-hypertensive treatment.

Conclusion

The importance of inflammatory markers in the early diagnosis of obesity-related hypertension may guide the development of new therapeutic strategies to treat target organ damage by reducing the morbidity and mortality that can be caused by hypertension. . We think that the high levels of inlammation markers in obese patients may be a guide in the severity of hypertension, in the prevention of organ damage secondary to hypertension, in reversing inflammation and hypertension with more stringent lifestyle changes, diet and exercise.

However, prospective studies which compare pre- and post-treatment inflammation in children are needed to evaluate the effects of inflammation and its effects on prognosis.