bluuebunny/crossref_metadata_2025 huggingface dataset:
Configuration of geoinformation system for monitoring and forecasting technosphere hazards on critical infrastructure
Authors: Niyazgulov U. D. , Tshovrebov E. S. , Beznosov V. N. , Tomilin V. F.
Published: October 2023

The paper is aimed at developing a system configuration for GIS-monitoring of the technical and environmental condition of living facilities for the subsequent prediction of technosphere threat in the format of prevention of natural and anthropogenic emergencies, as well as their environmental consequences. The methodology involved the system analysis of information obtained from monitoring the interrelated technical and resource-environmental parameters. The analysis considered the impact of various conditions, as well as limitations in the functioning of the living facilities. The obtained results underlay long-term and medium-term forecasts of options and scenarios for the development of hazardous processes, phenomena and consequences of adverse factors. The system analysis of information on technosphere hazards in housing and utility sector on the basis of the proposed GIS-monitoring determined areas for improving methods, algorithms, and tools for forecasting environmental hazards in order to prevent the associated threats and risks for population, natural environment and normal functioning of economic facilities. The proposed system configuration for GIS-monitoring of the technical and environmental condition of living facilities (on the example of housing and utilities services) can be used by the Unified state system for prevention and termination of emergency situations, regional and local authorities for forecasting and preventing natural and anthropogenic emergencies and their consequences for human life, environment, and sustainable livelihood systems in municipalities and regions.
Transparency and information asymmetry in the financial market: Strategic dependencies between sustainability disclosure, SDG achievement and financial and information efficiency
Authors: Makarenko Inna , Gryn Viktoriia , Proskurina Nelia , Pushkar lryna , Goncharova Valentina
Published: October 2023

In today’s financial world, the pursuit of sustainable development has evolved from an ethical imperative to a strategic necessity. It has spurred corporations to enhance transparency regarding their non-financial and responsible or ESG practices. This paper aims to formalize the strategic dependencies between sustainability disclosure, SDG achievement, and the financial and information efficiency of the financial market. The research methods are normality tests, canonical correlation analysis, and multivariate multiple and univariate regression analysis. The object of the study is 137 countries. The time period is 2022. The results confirmed that a positive strong correlation was found between sustainability disclosure and the achievement of the SDGs on the one hand and financial and information efficiency of the financial market on the other. Identifying the direction of the relationship also confirmed two-way positive dependencies between the indicators, in particular, the SDG Index will have the most significant impact on the growth of GDP per capita, the change in the Economic Sustainability Competitiveness Index on the growth of the United Nations Global Compact participants. The specified connection can be used as the basis for the formation of the concept of ensuring transparency and leveling information asymmetry in the activities of enterprises.
Examining the Relationship between Self-Efficacy and Cognitive Flexibility of Physical Education and Sports Teachers towards Inclusive Education
Authors: Kartal Erdem , Onbaşı Salim İbrahim , İlhan Ekrem Levent
Published: October 2023

Introduction: While cognitive flexibility includes adapt to changes quickly and flexibly, self-efficacy is explained as the confidence one has in one’s abilities and competencies. Inclusive education is based on the idea that each student has access to all kinds of educational opportunities. In this context, the aim of the study is to examine the self-efficacy of physical education and sports teachers towards inclusive education and to determine the role of cognitive flexibility.
Method: The population of the study consists of physical education and sports teachers working in public schools in Sakarya. A total of 157 (age = 40.83 ± 8.07) teachers, consisting of 120 males (76.4%) and 37 females (23.7%) recruited by convenience sampling, participated in the study designed with the relational screening model. "Teachers' Self-Efficacy Scale for the Education of Individuals with Special Needs," "Cognitive Flexibility Inventory," and the "Personal Information Form," developed by the researchers, were used as data collection tools. The data were analyzed in SPSS 22 using descriptive statistics, Pearson correlation, and regression analyses
Findings: It was determined that there was a positive, moderately significant relationship between teachers' cognitive flexibility levels and their self-efficacy for the education of individuals with special needs (TSEISN) (p < .05) and that cognitive flexibility had significant predictive power in explaining TSEISN (p < .05). Additionally, although no statistically significant difference was found in the participants' TSEISN and cognitive flexibility scores according to their course taking status (p > .05), their mean scores were determined to be high.
Discussion: It can be concluded that as teachers' cognitive flexibility increases, their self-efficacy towards individuals with special needs increases; in other words, the self-efficacy of teachers who can adapt to different environments and develop practical thinking skills is positively affected by these characteristics, and the self-efficacy levels of those who take courses for inclusive education are relatively high.
Molecular Modelling Based on TD-DFT Applied to UV Spectra of Coumarin Derivatives
Authors: Ariefin Mokhamat , Alfanaar Rokiy
Published: October 2023

The optimization of geometry and electronic transition of seven coumarin derivatives for sunscreen activity have been conducted using Orca. DFT methods is applied to find optimum geometry and parameter data is measured like bond length and bond angle. TD-DFT is conducted to get electronic transition to get ultraviolet (UV) spectra. The result shows that the coumarin derivative transition type is n to π* and π to π*. All coumarin exhibits the properties of UV-B protection, however, two out of seven show properties as a UV-A protection. The energy difference HOMO-LUMO shows that coumarin with isopropyl substituent has the smallest energy gap, around 0.1559, whereas coumarin with fluorine atom substituent has the biggest energy gap.
comparison of gold nanoparticles effectiveness in 2D and 3D cell culture.
Authors: Musielak Marika , Szymkowiak Barbara , Boś-Liedke Agnieszka
Published: October 2023

Tworzenie hodowli komórkowych w celach naukowych umożliwiła uzyskanie nowej wiedzy, a w konsekwencji dokonania odkryć w zakresie biologii komórki czy biofizyki. Badania in vitro pozwalają na obserwację linii komórkowych, a także interakcji z wprowadzonymi substancjami lub materiałami. Mają one nieoceniony wkład w rozwój nanomedycyny, która współcześnie cieszy się dużym zainteresowaniem. Szczególnie popularne i obiecujące, zwłaszcza pod względem walki z nowotworami, są nanocząstki złota (ang. gold nanoparticles, GNPs). Dzieje się tak, ze względu na specyficzne (m.in. elektryczne, magnetyczne, optyczne, mechaniczne) właściwości nanocząstek, znacznie różniących się od złota w skali makro.  Niestety, wyniki badań in vitro bywają czasem niezgodne z przeprowadzonymi badaniami in vivo. Nanocząstki, które sprawdzają się na płaszczyźnie komórkowej nie zawsze tak samo efektywnie działają na modelach zwierzęcych. Przyczyną tego faktu jest wielorakość złożonych procesów metabolicznych, zachodzących w organizmie podczas badań in vivo. Większość badań komórkowych wykonuje się na strukturach dwuwymiarowych, które odzwierciedlają rzeczywiste warunki w sposób przybliżony. Aktualnie, żadna z technik in vitro nie jest w stanie odzwierciedlić identycznych fizjologicznych warunków panujących w modelach zwierzęcych. Jednakże, współczesna nauka potrafi odwzorowywać je w sposób precyzyjniejszy używając hodowli trójwymiarowej (ang. 3-dimentional, 3D), która jest o wiele bardziej złożona. Projektując nowe badania należy wziąć pod uwagę wady i zalety każdej z wymienionych metod hodowli komórkowej. Niniejsza praca ma na celu przedstawienie różnic między hodowlą komórkową dwuwymiarową, a trójwymiarową z uwzględnieniem zastosowania nanocząstek złota.
Tools to Evaluate the Eco-efficiency of Analytical Methods in the Context of
Green and White Analytical Chemistry: A Review
Authors: Sinzervinch Aline , Torres Ieda Maria Sapateiro , Kogawa Ana Carolina
Published: October 2023

Background:

The release of a product in the consumer market requires an analysis by quality control.
This sector makes use of reliable analytical methods, by high performance liquid chromatography (HPLC),
spectrophotometry in the ultraviolet and visible regions (UV-Vis), spectrophotometry in the infrared region
(IR) or thin layer chromatography (TLC), for example, to reach a result. The analysis conditions of most
of these analytical methods currently still use toxic reagents, generate a greater amount of waste, sample preparation
has more steps, the need for instrumentation and consumables in greater quantity, generating a cost and
impact on health and the environment greater than if there were adoption of the Green Analytical Chemistry
(GAC) and the White Analytical Chemistry (WAC).

Objective/Methods:

The objective of this review is to show the relationship of analytical choices for current
pharmaceutical analyzes with the GAC and the WAC.

Results:

Analytical methods can be evaluated for greenness and whiteness using tools such as the National Environmental
Method Index (NEMI), Eco-Scale Assessment (ESA), Analytical Greenness Metric (AGREE)
and Green Analytical Procedure Index (GAPI).

Conclusion:

The use of NEMI, ESA, AGREE and GAPI tools brings the objective evidence needed to discuss
the greenness and whiteness of an analytical method, leaving the subjective level. Furthermore, semi or quantitative
data facilitate the choice of an analytical method and its conditions, when the target is the concern with
eco-efficiency.
Modulation of Plant MicroRNA Expression: Its Potential Usability in
Wheat (Triticum aestivum L.) Improvement
Authors: Lopos Louie Cris , Panthi Urbashi , Kovalchuk Igor , Bilichak Andriy
Published: October 2023

Wheat, a crucial crop for the pursuit of food security, is faced with a plateauing yield projected
to fall short of meeting the demands of the exponentially increasing human population. To raise
global wheat productivity levels, strong efforts must be made to overcome the problems of (1) climate
change-induced heat and drought stress and (2) the genotype-dependent amenability of wheat to tissue
culture, which limits the success of recovering genetically engineered plants, especially in elite cultivars.
Unfortunately, the mainstream approach of genetically engineering plant protein-coding genes
may not be effective in solving these problems as it is difficult to map, annotate, functionally verify,
and modulate all existing homeologs and paralogs within wheat’s large, complex, allohexaploid genome.
Additionally, the quantitative, multi-genic nature of most agronomically important traits furthers
the complications faced by this approach. miRNAs are small, noncoding RNAs (sncRNAs) that
repress gene expression at the post-transcriptional level, regulating various aspects of plant growth and
development. They are gaining popularity as alternative targets of genetic engineering efforts for crop
improvement due to their (1) highly conserved nature, which facilitates reasonable prediction of their
gene targets and phenotypic effects under different expression levels, and (2) the capacity to target
multiple genes simultaneously, making them suitable for enhancing complex and multigenic agronomic
traits. In this mini-review, we will discuss the biogenesis, manipulation, and potential applications
of plant miRNAs in improving wheat’s yield, somatic embryogenesis, thermotolerance, and
drought-tolerance in response to the problems of plateauing yield, genotype-dependent amenability to
tissue culture, and susceptibility to climate change-induced heat and drought stress.
Unraveling the Concealed Transcriptomic Landscape of PTEN in Human
Malignancies
Authors: Boti Michaela A. , Adamopoulos Panagiotis G. , Vassilacopoulou Dido , Scorilas Andreas
Published: October 2023

Background:

Phosphatase and tensin homolog, widely known as PTEN, is a major negative
regulator of the PI3K/AKT/mTOR signaling pathway, involved in the regulation of a variety of
important cellular processes, including cell proliferation, growth, survival, and metabolism. Since
most of the molecules involved in this biological pathway have been described as key regulators in
cancer, the study of the corresponding genes at several levels is crucial.

Objective:

Although previous studies have elucidated the physiological role of PTEN under normal
conditions and its involvement in carcinogenesis and cancer progression, the transcriptional profile
of PTEN has been poorly investigated.

Methods:

In this study, instead of conducting the “gold-standard” direct RNA sequencing that fails
to detect less abundant novel mRNAs due to the decreased sequencing depth, we designed and implemented
a multiplexed PTEN-targeted sequencing approach that combined both short- and longread
sequencing.

Results:

Our study has highlighted a broad spectrum of previously unknown PTEN mRNA transcripts
and assessed their expression patterns in a wide range of human cancer and non-cancer cell lines,
shedding light on the involvement of PTEN in cell cycle dysregulation and thus tumor development.

Conclusion:

The identification of the described novel PTEN splice variants could have significant
implications for understanding PTEN regulation and function, and provide new insights into PTEN
biology, opening new avenues for monitoring PTEN-related diseases, including cancer.
Targeting GM2 Ganglioside Accumulation in Dementia: Current Therapeutic Approaches and Future Directions
Authors: Kumar Sanjesh , Panda Siva Prasad
Published: October 2023

:

Dementia in neurodegenerative diseases, such as Alzheimer’s disease
(AD), Parkinson’s disease (PD), and dementia with Lewy bodies (DLB) is a
progressive neurological condition affecting millions worldwide. The amphiphilic
molecule GM2 gangliosides are abundant in the human brain and play important roles
in neuronal development, intercellular recognition, myelin stabilization, and signal
transduction. GM2 ganglioside’s degradation requires hexosaminidase A (HexA), a
heterodimer composed of an α subunit encoded by HEXA and a β subunit encoded by
HEXB. The hydrolysis of GM2 also requires a non-enzymatic protein, the GM2
activator protein (GM2-AP), encoded by GM2A. Pathogenic mutations of HEXA,
HEXB, and GM2A are responsible for autosomal recessive diseases known as GM2
gangliosidosis, caused by the excessive intralysosomal accumulation of GM2
gangliosides. In AD, PD and DLB, GM2 ganglioside accumulation is reported to
facilitate Aβ and α-synuclein aggregation into toxic oligomers and plaques through
activation of downstream signaling pathways, such as protein kinase C (PKC) and
oxidative stress factors. This review explored the potential role of GM2 ganglioside
alteration in toxic protein aggregations and its related signaling pathways leading to
neurodegenerative diseases. Further review explored potential therapeutic
approaches, which include synthetic and phytomolecules targeting GM2 ganglioside
accumulation in the brain, holding a promise for providing new and effective
management for dementia.
Herbal Candies: A Potential Source of Health Benefits
Authors: Kailey Rekha , Rasane Prasad , Singh Jyoti , Kaur Sawinder , Gunjal Mahendra , Kaur Jaspreet , Bhadariya Vishesh , Avinashe Harshal
Published: October 2023

Candy is a popular product consumed by children, young and elderly alike. The major
ingredient sugar makes it an instant source of energy, mostly blended with a variety of flavors and
colors for sensory and aesthetic appeal. Flavors such as caramel, chocolate, peppermint, butterscotch,
and vanilla are the most popular among many, that comprises of more than 2000 kinds. Although
synthetic flavors and colors are predominant, natural sources such as herbs are being increasingly
used. Herbal (made from herbs) products have lesser effects, more therapeutic effects,
and health benefits. The advantages of herbs used in candy manufacturing are safe, with good efficacy,
lower side effect, compatibility with the human body, and wide cultural acceptability. Herbal
candies are used as an efficient delivery system for vitamins, minerals, and numerous bioactive
compounds like anthocyanin, lycopene, ascorbic acid, etc. They are a remedy of choice in
case of cough, sore throat, digestive and stomach problems. The choice of herb often is influenced
based on the target health problem, reduced side effects, availability, and preferences. Apart from
sugar, these candies are also manufactured using sweetening agents. Sugar and sweeteners consumption
is associated with various myths and prejudices owing to increased health concerns. The
review is thus designed to justify various aspects of herbal candy like production process, ingredients,
historical importance, and types of herbal candies, myths, facts and risks, consumer awareness
towards herbal candies. The paper will also draw a roadmap for the future of herbal candy
amongst today’s health-wary consumers.
Study of the Effect of Palmitic Acid on the Expression of Myostatin mRNA
and its Cytotoxic Properties in the Culture of Myoblast Cells and the
Possibility of Exogenous Regulation
Authors: Kukes Vladimir G. , Furalyov Vladimir A. , Gazdanova Albina А. , Parfenova Olga K. , Grishin Dmitry V. , Sidorov Nikita G.
Published: October 2023

Objective:

To study the cytotoxic effect of palmitic acid on myoblasts in vitro and the
influence of this toxicant on the expression of myostatin mRNA in myoblast culture.

Methods:

To research the protective action against these processes of a compound with antioxidant activity, for which 2-ethyl-6-methyl-3-hydroxypyridine malate (ethoxidol) was chosen.

Results:

Our studies have shown that palmitic acid has a noticeable cytostatic effect on myoblasts
in vitro, significantly suppressing their proliferation: the rate of MTT recovery in myoblasts treated with palmitate was only 9.6% of that rate in control myoblasts. In experiments, it was shown
that palmitic acid slightly activated the expression of myostatin mRNA. At the same time, the
protective effect of 2-ethyl-6-methyl-3-hydroxypyridine malate was not so pronounced.

Conclusion:

The results of our research indicate that the activation of myostatin synthesis is not
one of the main causes of the development of myodystrophy in obese people or people following
a high-lipid diet, while the direct cytotoxic effect of palmitic acid on myoblasts is. It is obvious
that the use of antioxidants such as ethoxide has a protective effect on myoblasts in the experiment and may have a certain potential in clinical practice.
Molecular Docking Analysis of SARS-CoV-2 Inhibitor N3 (6LU7) against
Selected Flavonoids and Vitamins
Authors: Junapudi Sunil , Janapati Yasodha Krishna , Uppugalla Susmitha , Harris Timothy , Yaseen Muhammad , Latif Muhammad
Published: October 2023

Background: Coronavirus is a zoonotic disease and transmits between animals and humans.
The disease known as COVID-19 (SARS-CoV-2) has become a pandemic since its outbreak.
In addition to vaccines, a combination of antiretroviral agents, chloroquine derivatives, and vitamins
are being used to treat SARS-CoV-2.

Method: We performed molecular docking analysis of SARS-CoV-2 inhibitor N3 (6LU7) using a
series of flavonoid derivatives and vitamins. The X-ray crystallographic 3D structures of COVID-19
main protease in complex with an inhibitor N3 (PDB code: 6LU7, resolution 2.16 Å complexed with
a selective substance) were downloaded from the online Protein Data Bank. The structures of the
ligands and protein were constructed using ChemDrawUltra 8.0. The docking process, interactions,
and binding of ligands were visualized using the software Molegro Virtual Dockings (MVD). The
physicochemical and toxicity characteristics of tested flavonoid derivatives and vitamins were determined
using Swiss-ADME and pkCSM online software. We found that molecular docking scores
were between -64.42 and –172.00 Kcal/mol. The H-bonding and steric interactions were compared
with other flavonoid derivatives. The ADMET parameters suggested that compounds 4, 68, 90, 92,
and 94 have a higher GI rate.

Results: Our results also indicated that compound 78 was more potent and had higher skin permeation
than other flavonoid derivatives. The study showed that the compounds 5, 28, 74, 78, and folic
acid fitted well in the active site of COVID-19 inhibitor N3 (6LU7) and interacted with the residues
in the active site, which are essential for their biological activity.

Conclusion: Therefore, compounds 5, 28, 74, and 78 and folic acid can be a COVID-19 inhibitor N3
(6LU7) and might be used in the treatment of COVID-19 infection.
Law and constitutional guarantees in the Ecuadorian educational system of children and adolescents with disabilities
Authors: Parraga-Sánchez José Dimas
Published: October 2023

Education is a fundamental right determined in the Universal Declaration of Human Rights of 1948; it is legally guaranteed for everyone without any discrimination. The objective of the work “Right and constitutional guarantees in the Ecuadorian educational system of children and adolescents with disabilities” is to analyze the effective measures for the applicability of constitutional rights and guarantees in the educational system of people with disabilities. For its preparation, the documentary theoretical review methodology with a qualitative approach was used, using Articles related to inclusive education, from the Ecuadorian Constitution, Organic Law of Disabilities, Organic Law of Intercultural Education, information from UNESCO and Human Rights; also national and foreign scientific information from the Dialnet, Scielo, Redalyc databases, referring to this topic, with 5 years of publication, Laws and Decrees of 1948 and 1994, and from 2006 to 2016, which are rights and regulations that are maintained valid until today. The result was that from the educational legal framework there is still a long way to go for the full application of education for people with disabilities; training is required for regular education teaching staff, provision of material resources and personalized pedagogical adaptations, and more work with the environment.
Heymans’ Cube
Authors: Vermeij Rinske R. , Vroomen Corné H.F.L.
Published: October 2023

Gerard Heymans (1857-1930) was the founder of psychology in the Netherlands, and established the first psychological laboratory. After becoming professor, he first looked for general psychological laws, and later became interested in how people differ. Heymans investigated this question by studying biographies and collecting survey data. With this rigorous approach that far exceeded the standards of his time, he arrived at three basic dimensions in which people can vary in their temperament. This became the renowned 'Heymans' Cube'. Through decades of lectures for students and professors of all faculties, the theory became widely popular. This book provides a translation and adaptation of the original work, Heymans' lnleiding tot de speciale psychologie (1929). The authors explain Heymans' theory in an accessible way and make it come alive through illustrations inspired by the original text.
The role of adding potassium humate and foliar spraying with marine algae
on the mineral content and nutritional value of Moringa
Authors: Jaafar Omar Sarbaz Faki , Aziz Al-Jubouri Jassim Mohammad
Published: October 2023

An experiment was carried out in the plastic house at the Agricultural Research
Station in Bani Maqam, affiliated to Jam Jamal Agriculture Directorate in
Sulaymaniyah Governorate, in a randomized complete block design, with three
replications, on June 10, 2021. Furthermore, 4, 8, 12 and 16 kg hectares when
planting and before the first irrigation and after each mowing process, and the
second factor was spraying with seaweed extract Alga000 at three levels 0, 1, and
2 ml (2 and 4 ml per liter of total spray) and at two intervals after 20 and 30 days
of planting After 10 and 25 days of mowing, at a height of 20 cm from the surface of the ground, the mineral content of leaves and dry stems samples of the
first mowing plants was estimated. It included the content of calcium, iron and
manganese (mg/100g dry matter) and the percentage of nitrogen, phosphorous
and potassium. Indicators of the nutritional value of the leaves and stems of the
first mow, which included the estimation of the percentage of total carbohydrates,
ash, protein and fiber. The results showed that adding 16 kg hectares of potassium humate and spraying at a concentration of 2 ml per liter twice with algae extract Bahriya recorded the highest content of iron (42.3 and 19.82), calcium
(2103.7 and 1009.29) and manganese (40 and 10.15) mg/100 g of dry matter for
leaves and stems. The highest percentage of phosphorous was 0.333% in dry
leaves, and the highest percentage of nitrogen (3.89%) and 1.58%), potassium
(1.601% and 1.24%), protein (24.314% and 9.885%), total carbohydrates
(35.23% and 11.86%), and the lowest fiber content (4.57% and 25.45%) in the
dry matter. For leaves and stems .
Keywords: moringa, potassium humate, marine algae, mineral content, nutritional value
Response of Local Garlic to Potassium and Sulfur Fertilization Method
Authors: A. Al-Mohammadi Raed K. , Al-Abdaly Maath M. M.
Published: October 2023

A field experiment was conducted at the Agricultural Research Station of the
College of Agriculture, University of Anbar, for the agricultural season 2021-
2022. This experiment aimed to study the effect of potassium and sulfur application on local garlic's growth, yield, and quality. The experiment included four
levels of potassium soil fertilization (0, 200, 250, and 300 kg.ha-1
), three levels of
foliar spraying of potassium (0, 5, and 10 g.L-1
), and three levels of soil fertilization of sulfur (0, 40, and 50 kg.ha-1
). The study used the randomized complete
block design (RCBD) in combinations. The results showed significant differences
in the characteristics of vegetative growth, yield characteristics, and qualitative
characteristics. The combination (300 kg K2O.ha-1 +10 g.L-1 + 50 kg S.ha-1
) significantly exceeded by giving the highest leaves number, leaves area and shoot
dry weight, which amounted to 11.42 leaf.plant-1 and 795.00 cm2
.plant-1
and
10.87 g.plant-1
, respectively. In comparison, the control treatment gave (8.80
leaves.plant-1 and 571.00 cm2
.plant-1
and 8.17 g.plant-1
), for the same above traits,
respectively. The same combination achieved a significant increase in yield traits
(cloves number, clove weight, yield/plant, and total yield) with 37.58 cloves, 2.71
g, 102.03 g, and 51.01 t.ha-1
, respectively, compared to the control treatment,
which gave (32.00 cloves, 1.81 g, 58.17 g, and 29.08 t.ha-1
). The same treatment
led to an increase in the percentage of potassium and sulfur in the bulbs, which
recorded the highest percentage of 1.67% and 0.60%, respectively, compared to
the control treatment, which recorded the lowest percentage of 1.36% and 0.40%,
respectively.
Keywords: Garlic, Fertilization, Potassium, Sulfur, Growth, Yield.
The Readability and Quality of Web-Based Patient Information on Nasopharyngeal Carcinoma: Quantitative Content Analysis
Authors: Tan Denise Jia Yun , Ko Tsz Ki , Fan Ka Siu
Published: October 2023

Background

Nasopharyngeal carcinoma (NPC) is a rare disease that is strongly associated with exposure to the Epstein-Barr virus and is characterized by the formation of malignant cells in nasopharynx tissues. Early diagnosis of NPC is often difficult owing to the location of initial tumor sites and the nonspecificity of initial symptoms, resulting in a higher frequency of advanced-stage diagnoses and a poorer prognosis. Access to high-quality, readable information could improve the early detection of the disease and provide support to patients during disease management.

Objective

This study aims to assess the quality and readability of publicly available web-based information in the English language about NPC, using the most popular search engines.

Methods

Key terms relevant to NPC were searched across 3 of the most popular internet search engines: Google, Yahoo, and Bing. The top 25 results from each search engine were included in the analysis. Websites that contained text written in languages other than English, required paywall access, targeted medical professionals, or included nontext content were excluded. Readability for each website was assessed using the Flesch Reading Ease score and the Flesch-Kincaid grade level. Website quality was assessed using the Journal of the American Medical Association (JAMA) and DISCERN tools as well as the presence of a Health on the Net Foundation seal.

Results

Overall, 57 suitable websites were included in this study; 26% (15/57) of the websites were academic. The mean JAMA and DISCERN scores of all websites were 2.80 (IQR 3) and 57.60 (IQR 19), respectively, with a median of 3 (IQR 2-4) and 61 (IQR 49-68), respectively. Health care industry websites (n=3) had the highest mean JAMA score of 4 (SD 0). Academic websites (15/57, 26%) had the highest mean DISCERN score of 77.5. The Health on the Net Foundation seal was present on only 1 website, which also achieved a JAMA score of 3 and a DISCERN score of 50. Significant differences were observed between the JAMA score of hospital websites and the scores of industry websites (P=.04), news service websites (P<.048), charity and nongovernmental organization websites (P=.03). Despite being a vital source for patients, general practitioner websites were found to have significantly lower JAMA scores compared with charity websites (P=.05). The overall mean readability scores reflected an average reading age of 14.3 (SD 1.1) years.

Conclusions

The results of this study suggest an inconsistent and suboptimal quality of information related to NPC on the internet. On average, websites presented readability challenges, as written information about NPC was above the recommended reading level of sixth grade. As such, web-based information requires improvement in both quality and accessibility, and healthcare providers should be selective about information recommended to patients, ensuring they are reliable and readable.
A Conference (Missingness in Action) to Address Missingness in Data and AI in Health Care: Qualitative Thematic Analysis
Authors: Rose Christian , Barber Rachel , Preiksaitis Carl , Kim Ireh , Mishra Nikesh , Kayser Kristen , Brown Italo , Gisondi Michael
Published: October 2023

Background

Missingness in health care data poses significant challenges in the development and implementation of artificial intelligence (AI) and machine learning solutions. Identifying and addressing these challenges is critical to ensuring the continued growth and accuracy of these models as well as their equitable and effective use in health care settings.

Objective

This study aims to explore the challenges, opportunities, and potential solutions related to missingness in health care data for AI applications through the conduct of a digital conference and thematic analysis of conference proceedings.

Methods

A digital conference was held in September 2022, attracting 861 registered participants, with 164 (19%) attending the live event. The conference featured presentations and panel discussions by experts in AI, machine learning, and health care. Transcripts of the event were analyzed using the stepwise framework of Braun and Clark to identify key themes related to missingness in health care data.

Results

Three principal themes—data quality and bias, human input in model development, and trust and privacy—emerged from the analysis. Topics included the accuracy of predictive models, lack of inclusion of underrepresented communities, partnership with physicians and other populations, challenges with sensitive health care data, and fostering trust with patients and the health care community.

Conclusions

Addressing the challenges of data quality, human input, and trust is vital when devising and using machine learning algorithms in health care. Recommendations include expanding data collection efforts to reduce gaps and biases, involving medical professionals in the development and implementation of AI models, and developing clear ethical guidelines to safeguard patient privacy. Further research and ongoing discussions are needed to ensure these conclusions remain relevant as health care and AI continue to evolve.
Reliability, Quality, and Science popularity of Diabetes Knowledge Information in China Video Sharing Platform: A Cross-sectional Study (Preprint)
Authors: Sun Kexin , Cui Chen , Mu Fei , Tang Meng , Gong Rui , Yan Zhen , Zhao Jinyi , Wang Jingwen
Published: October 2023

BACKGROUND

More and more diabetes individuals are using internet video platforms for self-management of blood glucose in China. TikTok, WeChat and Bilibili, have gained popularity because of the easy access to health information. However, the quality, reliability and science popularity of health information on these platforms have still not been fully assessed, and studies comparing the three platforms are lacking.

OBJECTIVE

A cross-sectional study was established to evaluate the reliability, quality and science popularity of diabetes health information in Chinese Internet video platforms.

METHODS

This study used 'diabetes' as a keyword to identify the top 100 videos meeting the specified criteria on each platform, resulting in 300 videos. The modified DISCERN score, the Journal of the American Medical Association Score (JAMAS) benchmark criteria, and Global Quality Scores (GQS) were employed to assess the reliability of videos. This study developed criteria to evaluate the scientific popularity of the platforms. Each video was assessed based on the health information categories recommended by the Chinese Diabetes Guidelines (2022).

RESULTS

Of the videos retrieved, 68.67% (206/300) were released by certified medical professionals. Diet was the most frequently discussed topic (83%). TikTok achieved the lowest DISCERN scores (median 2, IQR:2.00) compared with Bilibili (median 3, IQR: 2.00) and WeChat (median 3, IQR: 0.00). The median JAMA criterion score was 3 (IQR:1.00) for all three platforms. The science popularity score of Bilibili (median 80, IQR: 13.75) was highest. The overall GQS quality of Bilibili (median: grade 3) and WeChat (median: grade 3) was higher than the TikTok platform (median 2). Among diabetes guideline scores, the highest median score was Bilibili (median 2, IQR: 3.00), which was higher than TikTok (median 1, IQR 1.00) and WeChat (median 1, IQR 1.00). The science popularity of medical professionals was significantly lower than non-medical professionals.

CONCLUSIONS

Information from Chinese Internet video platforms is generally of fairly reliable quality. Bilibili received the best quality, reliability and popularity of science compared with TikTok and WeChat. All three platforms cover little information about medication. Health professionals should be encouraged to produce high-quality diabetes health science popularization works to enhance the standard of scientific communication.
Trends and projections in lung and bronchus cancer incidence and mortality in the United States, 2000–2030：an age-period-cohort study (Preprint)
Authors: Chen Fangyao , Luo Yaqi , Chen Shiyu , Si Aima , Hu Weiwei , Zhang Yuxiang , Yang Yuhui , Cai Jiaxin , Zhang Jia
Published: October 2023

BACKGROUND

Despite the declining incidence, lung and bronchus (lung hereafter) cancer remains a major public health concern worldwide. In addition to its high mortality rate, lung cancer carries significant economic and social costs. Monitoring trends in lung cancer incidence and mortality is critical to understanding the burden of the disease, identifying risk factors and potential interventions, and improving public health policy and medical resource allocation.

OBJECTIVE

To explore and project the trends in incidence and mortality rates for different histologic subtypes of lung cancer, diagnostic stages, and other tumor-related characteristics based on the surveillance data.

METHODS

Lung cancer incidence and mortality-based trends were estimated from the Surveillance, Epidemiology and End Results (SEER-17) program. Trends in age-adjusted incidence and incidence-based mortality rates were estimated using log-linear regression considering demographic characteristics of responders and tumor features such as histologic type and SEER tumor stage. The Bayesian age-period-cohort model was utilized to predict trends in lung cancer incidence and mortality rates for 2020-2030.

RESULTS

Of the 811,276 lung cancer cases diagnosed during 2000-2019 in the SEER-17 (male, 53.3%; white, 82.8%; 60-79 years, 63.23%; NSCLC, 86.3%), 533,272 patients died during 2005-2019. Lung cancer incidence continued to decline during 2000-2019, from 58.10 per 100,000 in 2000 to 38.88 per 100,000 in 2019, with an average annual decline of 2.1% (95% CI: -2.2% to -2.0%). Concurrently, the incidence-based mortality rate decreased at an average of 2.4% (95% CI: -2.7% to -2.1%) per year, from 46.6 per 100,000 in 2005 to 33.6 per 100,000 in 2009. Despite these overall declines, an upward trend was observed in both incidence and incidence-based mortality rates among early-stage cases across various subgroups delineating NSCLC tumor characteristics. The projected results of Bayesian age-period-cohort analyses suggest varying degrees of decreasing trends in lung cancer incidence, mortality, and incidence-based mortality rates for populations of different genders and age groups in the SEER-17 region over the next decade.

CONCLUSIONS

The incidence of lung cancer continues to decline (2.1% per year) among lung cancer patients diagnosed from 2000 to 2019 in the SEER-17 region, and the histologic type of diagnosed lung cancer cases continues to be predominantly non-small cell lung cancer (NSCLC, 86.3%), which continues to show a downward trend in the SEER-17 region over the next decade. Early lung cancer incidence and incidence-based mortality rates are trending upward, which may be related to tobacco control measures and early screening and early diagnosis and treatment of lung cancer in the United States.
Guerrero de silicio: ecos a la obra Frantz Fanon
Authors: Vargas Canales Margarita Aurora
Published: October 2023

En este libro presentamos seis libros que analizan diferentes aspectos de la obra de Frantz Fanon, su recepción en América Latina y los ecos y diálogos que, a noventa años de su nacimiento, producen en investigadores de la Universidad Nacional Autónoma de México convocados en el marco del proyecto de investigación PAPIIT "El pensamiento anticolonialista en el Caribe Insular francófono (1950-1982)". Una versión preliminar de estos trabajos de investigación se presentó en el coloquio "La nación en armas: elementos para pensar la cultura nacional en Frantz Fanon", realizado en septiembre de 2015, en el Centro de Investigaciones sobre América Latina y el Caribe de la UNAM, en el marco del proyecto de investigación referido.
Revisión de la calidad nutricional de botón de oro y de afrecho de yuca para la producción de ensilajes en ganadería de leche
Authors: Castaño-Jiménez Gastón Adolfo , Barragán-Hernández Wilson Andrés , Mahecha-Ledesma Liliana , Angulo-Arizala Joaquín
Published: October 2023

El botón de oro (Tithonia diversifolia (Hemsl.) A. Gray) es un forraje promisorio en ganadería de leche, debido al relativamente elevado contenido de proteína y carbohidratos no fibrosos; además, posee metabolitos secundarios que pueden modular la fermentación ruminal hacia vías metabólicas más eficientes para el animal y menos perjudiciales para el medio ambiente. El valor nutritivo del botón de oro por su estado fenológico ayuda a establecer estrategias de manejo que benefician el desempeño de los animales, sin perjudicar el forraje. Por otra parte, el afrecho de yuca es un subproducto de la extracción del almidón de yuca (Manihot esculenta Crantz) con potencial uso en alimentación de ganado lechero, por su elevada concentración de almidón. El proceso de ensilaje favorece el uso del botón de oro, pues permite cosecharlo de acuerdo con la edad fenológica, mantener estable la oferta de forraje y disminuir los costos de producción. Utilizar aditivos como azúcar, melaza y jugo fermentado de flora epífita pueden contribuir al proceso de fermentación ácido láctica y disminuir la pérdida de nutrientes durante la elaboración de ensilajes. Emplear afrecho de yuca al elaborar ensilaje de botón de oro, contribuye a la conservación del forraje porque disminuye la humedad y aporta carbohidratos de fácil fermentación. El ensilado mixto de botón de oro y afrecho de yuca benefician la alimentación del ganado lechero, debido al contenido de proteína y metabolitos secundarios del botón de oro, sumado al aporte de almidón del afrecho de yuca; sin embargo, esta hipótesis deber ser desafiada experimentalmente.
Educación superior privada durante la reforma neoliberal en dos regiones de Michoacán
Authors: Ávila Meléndez Luis Arturo
Published: October 2023

El artículo sintetiza la perspectiva de análisis cultural que orientó una investigación sobre el desarrollo de dos instituciones de educación superior privadas en Michoacán. Así, busco explicar el desarrollo de un nuevo Estado neoliberal mexicano considerando sus efectos diferenciados por regiones en el funcionamiento de las instituciones de educación superior privadas. Primero, detallo algunos procesos económico políticos y culturales del siglo XX que han tenido consecuencias duraderas en dos regiones de Michoacán, y que resultan pertinentes para comprender el peculiar desenvolvimiento de las dos instituciones analizadas. En seguida presento las adaptaciones y propuestas que hace cada institución frente a algunas tendencias predominantes de la política educativa nacional a partir de los años ochenta que condicionan su funcionamiento. Argumento que dichas respuestas están orientadas por las culturas regionales en las que emergió cada institución.
Pautas bioéticas. La industria farmacéutica entre la ciencia y el mercado
Authors: Páez Moreno Ricardo
Published: October 2023

¿Te preocupa el estado de la distribución de los servicios de salud a nivel mundial y en México? En esta obra el autor reflexiona sobre el comportamiento de la industria farmacéutica y señala, de manera documentada, cómo los intereses de los laboratorios se ponen por encima de los pacientes. Así, ofrece un modelo alternativo de justicia, ética y filosofía que atiende los factores estructurales que producen las graves desigualdades imperantes en la investigación médica.
Study of Tall Structures Subjected to Seismic Forces with Irregular Structural Forms
Authors: P Anusha
Published: October 2023

Abstract: The advancement of technology and the increased economic development of the countries have brought about a new era in construction of high-rise buildings. With the significant improvement in construction technology it is witnessed that new structural systems being adopted in the design of tall buildings. One among them is the irregular structural system. Irregular structural system resists lateral loads. In the present study, a 45-storey high rise structure is considered. Five different irregular structural forms are modelled using ETABS software. The models such as simple framed structure, simple tube structure, tube in tube, bundled tube and hybrid tube structure is considered. Models are analyzed for static and dynamic response spectrum analysis. The results are extracted and compared. The conclusions are as below. The Displacement values of static and dynamic analysis are not same and having a difference of around 25%. This is a huge reduction. The dynamic analysis is more suitable for high rise building and it is proved to be economical in terms of displacement and reduces the major construction cost by reducing unnecessary increase in member sizes.
COR E GÊNERO INFLUENCIAM O COMPORTAMENTO SUICIDA DOS BRASILEIROS: Uma análise de correspondência usando o pacote caintertools
Authors: Camêlo Edwirde Luiz Silva , Aguiar Dalila Camêlo , Ribeiro Maria Clara da Costa , Sánchez Ramón Gutierrez
Published: October 2023

Suicide is a multidetermined biopsychosocial phenomenon that involves the subjectivity and the environment experienced by individuals. The study aimed to analyze the correspondence between gender and race in the Brazilian regions in 2020 about suicide. A descriptive, quantitative study was carried out, based on the collection of the DATASUS database, in October 2022. Multivariate dimension reduction techniques were used, together with correspondence analysis and cluster analysis, in the rows representing the 27 states of the federation and the types of races as column variables. In the Southeast, the highest suicide rate is for the brown and black races, especially SP, RJ, and PR. We observed the association of indigenous suicide in the state of AM. In CO, there was also variability in the yellow race. The lowest rates were in AP, ES, and RR. The Northeast region had the lowest suicide rates by race. The indigenous race has a weak correlation with the other races. In the states of SC, RS, SP, and PR, suicides by race are associated with the white race. Thus, the number of suicides in Brazilian states is associated with race, color, and gender.
A INFLUENCIA DAS REDES SOCIAIS NO HIPERCONSUMO NA SOCIEDADE PÓS-MODERNA
Authors: Gomes Mariana Helloá de Oliveira
Published: October 2023

This work aims to reflect the use of social networks, in which people consume products incessantly and transform themselves into an object of consumption. Initially, the path of development of social networks will be covered and, subsequently, the characteristics of postmodern society and guiding principles will be explored, as well as the demand for psychotherapy within this immediate context. In sequence, an understanding of the mechanisms for inducing consumption will be sought. The research is a bibliographical review with a qualitative approach, developed through an exploration of the literature deemed relevant to the theme with a period of publication between 1993 and 2019 with free access and in the Portuguese language based mainly on the thoughts of Bauman and Lipovetsky, found in the databases of online data Google Scholar, Digital Library of Theses and Dissertations (BDTD) Electronic Journals in Psychology (PEPSIC) and Scientif Electronic Library Online (SCIELO), and support from own collection. It can be seen that social networks influence exacerbated consumption, due to their persuasive nature and manipulation strategies.
The fate of a scientist: Bashir Iskandarovich Rameev
Authors:   Penza State Technological University, Novinskaya Taisiya Yu.
Published: October 2023

The article is dedicated to the life and work of Bashir Iskandarovich Rameev, one of the founders of domestic computer technology in the USSR, whose professional activities were closely connected with the city of Penza. In the 1950s, the largest research institute for electronic computing machines was established based on the SAM plant in Penza. The article focuses on the scientist's life path, which reflects the history of the country – the revolution of 1917, repressions, the Great Patriotic War, the achievements of Soviet science and technology in the post-war years in the setting of the Cold War. The formation of B.I. Rameev as a scientist coincided with the development of the first information technologies – the development of the first domestic computer “Strela”. The creation of a galaxy of electronic computing machines “Ural” falls on the peak of his career, when the scientist fullfilled the “principle of programmatic and constructive compatibility”.