bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of pathological remodeling in the chronic atrioventricular block cynomolgus monkey heart
Authors: Izumi-Nakaseko Hiroko , Sakamoto Kengo , Goto Ai , Kambayashi Ryuichi , Matsumoto Akio , Takei Yoshinori , Takahara Akira , Sugiyama Atsushi
Published: January 2023

We studied time course of pathological remodeling occurring in the cynomolgus monkey hearts against persistent atrioventricular block condition (n = 10). The atrioventricular block induced the ventricular and atrial dilation followed by the ventricular hypertrophy. Interstitial fibrosis in the ventricle was also observed along with gradual increases in the plasma angiotensin II and aldosterone concentrations. These adaptations were associated with the changes in gene expression profiling reflecting fibrosis and hypertrophy. Atrioventricular block reduced the ventricular rate and cardiac output, but the ejection fraction and stroke volume increased, whereas the cardiac output was gradually restored to its basal level. Systolic/diastolic blood pressure after the atrioventricular block was kept equal to or lower than that before the block, according with lack of increase in the plasma catecholamine levels. Chronic atrioventricular block gradually prolonged the QRS width and JT interval, leading to the QT interval prolongation in conscious state. 10 mg/kg of dl-sotalol hydrochloride induced torsade de pointes (TdP) in 6 out of 10 animals by 15 months. Animals showing longer QTcF under anesthesia after the atrioventricular block developed dl-sotalol-induced TdP earlier. No marked difference was observed in pharmacokinetics of dl-sotalol between 1 and 7 months after the atrioventricular block. Each TdP spontaneously terminated, reflecting a monkey’s relatively small “effective size of the heart (=∛(left ventricular weight)/wavelength of reentry)”. These fundamental knowledge will help better utilize the chronic atrioventricular block monkeys as an in vivo proarrhythmia model for detecting drug-induced TdP.
Stimulation of soluble guanylate cyclase by vericiguat reduces skeletal muscle atrophy of mice following chemotherapy
Authors: Hu Bo-ang , Li Yu-lin , Han Hai-tao , Lu Bin , Jia Xu , Han Lu , Ma Wei-xuan , Zhu Ping , Wang Zhi-hao , Zhang Wei , Zhong Ming , Zhang Lei
Published: January 2023

Background: The chemotherapeutic doxorubicin (DOX) promotes severe skeletal muscle atrophy, which induces skeletal muscle weakness and fatigue. Soluble guanylate cyclase (sGC) contributes to a variety of pathophysiological processes, but whether it is involved in DOX-induced skeletal muscle atrophy is unclear. The present study aimed to stimulate sGC by vericiguat, a new oral sGC stimulator, to test its role in this process.

Methods: Mice were randomly divided into four groups: control group, vericiguat group, DOX group, and DOX + vericiguat group. Exercise capacity was evaluated before the mice were sacrificed. Skeletal muscle atrophy was assessed by histopathological and molecular biological methods. Protein synthesis and degradation were monitored in mice and C2C12 cells.

Results: In this study, a significant decrease in exercise capacity and cross-sectional area (CSA) of skeletal muscle fibers was found in mice following DOX treatment. Furthermore, DOX decreased sGC activity in mice and C2C12 cells, and a positive correlation was found between sGC activity and CSA of skeletal muscle fibers in skeletal muscle. DOX treatment also impaired protein synthesis, shown by puromycin detection, and activated ubiquitin-proteasome pathway. Following sGC stimulation, the CSA of muscle fibers was elevated, and exercise capacity was enhanced. Stimulation of sGC also increased protein synthesis and decreased ubiquitin-proteasome pathway. In terms of the underlying mechanisms, AKT/mTOR and FoxO1 pathways were impaired following DOX treatment, and stimulation of sGC restored the blunted pathways.

Conclusion: These results unravel sGC stimulation can improve skeletal muscle atrophy and increase the exercise capacity of mice in response to DOX treatment by enhancing protein synthesis and inhibiting protein degradation. Stimulation of sGC may be a potential treatment of DOX-induced skeletal muscle dysfunction.
Multistep ahead atmospheric optical turbulence forecasting for free-space optical communication using empirical mode decomposition and LSTM-based sequence-to-sequence learning
Authors: Li Yalin , Zhang Hongqun , Li Lang , Shi Lu , Huang Yan , Fu Shiyao
Published: January 2023

Although free-space optical communication (FSOC) is a promising means of high data rate satellite-to-ground communication, beam distortion caused by atmospheric optical turbulence remains a major challenge for its engineering applications. Accurate prediction of atmospheric optical turbulence to optimize communication plans and equipment parameters, such as adaptive optics (AO), is an effective means to address this problem. In this research, a hybrid multi-step prediction model for atmospheric optical turbulence, EMD-Seq2Seq-LSTM, is proposed by combining empirical mode decomposition (EMD), sequence-to-sequence (Seq2Seq), and long short-term memory (LSTM) network. First, using empirical mode decomposition to decompose the non-linear and non-stationary atmospheric optical turbulence dataset into a set of stationary components for which internal feature information can be easily extracted significantly reduces the training difficulty and improves the forecast accuracy of the model. Second, sequence-to-sequence is combined with LSTM networks to build a prediction model that can eliminate time delay and make full use of long-term information and then use the model to predict each component separately. Finally, the prediction results of each component are combined to obtain the final atmospheric turbulence forecasting results. To validate the performance of the proposed method, three comparative models, including WRF, LSTM, and sequence-to-sequence-LSTM, are demonstrated in this study. The forecasting results reveal that the proposed model outperforms all other models both qualitatively and quantitatively and thus can be a powerful method for atmospheric optical turbulence forecasting.
The profit and risk in the interdisciplinary behavior
Authors: Fu Chenbo , Luo Haogeng , Liang Xuejiao , Yu Shanqing
Published: January 2023

Evaluating the influence of interdisciplinary research is important to the development of science. This work considers the large and small disciplines, calculates the interdisciplinary distance, and analyzes the influence of interdisciplinary behavior and interdisciplinary distance in the academic network. The results show that the risk of interdisciplinary behavior in the large discipline is more significant than the benefits. The peer in the small disciplines will tend to agree with the results of the small discipline across the large discipline. We further confirmed this conclusion by utilizing PSM-DID. The analysis between interdisciplinary distance and scientists’ influence shows that certain risks will accompany any distance between disciplines. However, there still exists a “Sweet Spot” which could bring significant rewards. Overall, this work provides a feasible approach to studying and understanding interdisciplinary behaviors in science.
Study of multispectral polarization imaging in sea fog environment
Authors: Fu Qiang , Yang Wei , Si Linlin , Zhang Meng , Zhang Yue , Luo Kaiming , Zhan Juntong , Zhang Su
Published: January 2023

Marine exploration has become a popular field of concern and research all over the world. The impact of sea fog on ocean exploration is very great, and how to carry out accurate identification of targets in the sea fog environment is a problem we urgently need to solve. In this paper, we simulated and analyzed the particle distribution characteristics of the sea fog layer by using the principle of Mie scattering, designed a spectral polarization imaging system by using Liquid Crystal Variable Retarder (LCVR) and Liquid Crystal Tunable Filter (LCTF) according to the principle of spectral spectroscopy and polarization imaging, conducted calibration experiments on liquid crystal tunable filter, and carried out experiments on visibility, wavelength and imaging distance that affect the experimental results of polarization imaging of sea fog environment. The experimental results show that the polarization decreases with the increase of imaging distance; in the typical visibility (5 km for light fog, 0.5 km for medium fog and 0.05 km for dense fog), the higher the visibility, the higher the polarization; for the typical wavelengths of visible light (450 nm, 530 nm and 670 nm), the polarization increase with the increase of wavelength.
Physiological changes associated with copper sulfate-induced nausea and retching in felines
Authors: Murphey Charles P. , Shulgach Jonathan A. , Amin Pooja R. , Douglas Nerone K. , Bielanin John P. , Sampson Jacob T. , Horn Charles C. , Yates Bill J.
Published: January 2023

Nausea is a common disease symptom, yet there is no consensus regarding its physiological markers. In contrast, the process of vomiting is well documented as sequential muscular contractions of the diaphragm and abdominal muscles and esophageal shortening. Nausea, like other self-reported perceptions, is difficult to distinguish in preclinical models, but based on human experience emesis is usually preceded by nausea. Here we focused on measuring gastrointestinal and cardiorespiratory changes prior to emesis to provide additional insights into markers for nausea. Felines were instrumented to chronically record heart rate, respiration, and electromyographic (EMG) activity from the stomach and duodenum before and after intragastric delivery of saline or copper sulfate (CuSO4, from 83 to 322 mg). CuSO4 is a prototypical emetic test agent that triggers vomiting primarily by action on GI vagal afferent fibers when administered intragastrically. CuSO4 infusion elicited a significant increase in heart rate, decrease in respiratory rate, and a disruption of gastric and intestinal EMG activity several minutes prior to emesis. The change in EMG activity was most consistent in the duodenum. Administration of the same volume of saline did not induce these effects. Increasing the dose of CuSO4 did not alter the physiologic changes induced by the treatment. It is postulated that the intestinal EMG activity was related to the retrograde movement of chyme from the intestine to the stomach demonstrated to occur prior to emesis by other investigators. These findings suggest that monitoring of intestinal EMG activity, perhaps in combination with heart rate, may provide the best indicator of the onset of nausea following treatments and in disease conditions, including GI disease, associated with emesis.
Sleep benefits different stages of memory in Drosophila
Authors: Marquand Katie , Roselli Camilla , Cervantes-Sandoval Isaac , Boto Tamara
Published: January 2023

Understanding the physiological mechanisms that modulate memory acquisition and consolidation remains among the most ambitious questions in neuroscience. Massive efforts have been dedicated to deciphering how experience affects behavior, and how different physiological and sensory phenomena modulate memory. Our ability to encode, consolidate and retrieve memories depends on internal drives, and sleep stands out among the physiological processes that affect memory: one of the most relatable benefits of sleep is the aiding of memory that occurs in order to both prepare the brain to learn new information, and after a learning task, to consolidate those new memories. Drosophila lends itself to the study of the interactions between memory and sleep. The fruit fly provides incomparable genetic resources, a mapped connectome, and an existing framework of knowledge on the molecular, cellular, and circuit mechanisms of memory and sleep, making the fruit fly a remarkable model to decipher the sophisticated regulation of learning and memory by the quantity and quality of sleep. Research in Drosophila has stablished not only that sleep facilitates learning in wild-type and memory-impaired animals, but that sleep deprivation interferes with the acquisition of new memories. In addition, it is well-accepted that sleep is paramount in memory consolidation processes. Finally, studies in Drosophila have shown that that learning itself can promote sleep drive. Nevertheless, the molecular and network mechanisms underlying this intertwined relationship are still evasive. Recent remarkable work has shed light on the neural substrates that mediate sleep-dependent memory consolidation. In a similar way, the mechanistic insights of the neural switch control between sleep-dependent and sleep-independent consolidation strategies were recently described. This review will discuss the regulation of memory by sleep in Drosophila, focusing on the most recent advances in the field and pointing out questions awaiting to be investigated.
Airway remodeling heterogeneity in asthma and its relationship to disease outcomes
Authors: Hsieh Aileen , Assadinia Najmeh , Hackett Tillie-Louise
Published: January 2023

Asthma affects an estimated 262 million people worldwide and caused over 461,000 deaths in 2019. The disease is characterized by chronic airway inflammation, reversible bronchoconstriction, and airway remodeling. Longitudinal studies have shown that current treatments for asthma (inhaled bronchodilators and corticosteroids) can reduce the frequency of exacerbations, but do not modify disease outcomes over time. Further, longitudinal studies in children to adulthood have shown that these treatments do not improve asthma severity or fixed airflow obstruction over time. In asthma, fixed airflow obstruction is caused by remodeling of the airway wall, but such airway remodeling also significantly contributes to airway closure during bronchoconstriction in acute asthmatic episodes. The goal of the current review is to understand what is known about the heterogeneity of airway remodeling in asthma and how this contributes to the disease process. We provide an overview of the existing knowledge on airway remodeling features observed in asthma, including loss of epithelial integrity, mucous cell metaplasia, extracellular matrix remodeling in both the airways and vessels, angiogenesis, and increased smooth muscle mass. While such studies have provided extensive knowledge on different aspects of airway remodeling, they have relied on biopsy sampling or pathological assessment of lungs from fatal asthma patients, which have limitations for understanding airway heterogeneity and the entire asthma syndrome. To further understand the heterogeneity of airway remodeling in asthma, we highlight the potential of in vivo imaging tools such as computed tomography and magnetic resonance imaging. Such volumetric imaging tools provide the opportunity to assess the heterogeneity of airway remodeling within the whole lung and have led to the novel identification of heterogenous gas trapping and mucus plugging as important predictors of patient outcomes. Lastly, we summarize the current knowledge of modification of airway remodeling with available asthma therapeutics to highlight the need for future studies that use in vivo imaging tools to assess airway remodeling outcomes.
Autumn phenology of tree species in China is associated more with climate than with spring phenology and phylogeny
Authors: Gao Xinyue , Dai Junhu , Tao Zexing , Shahzad Khurram , Wang Huanjiong
Published: January 2023

Both biotic and abiotic factors restrict changes in autumn phenology, yet their effects remain ambiguous, which hinders the accurate prediction of phenology under future climate change. In this study, based on the phenological records of 135 tree species at ten sites in China during 1979–2018, we first investigated the effects of climatic factors (temperature, precipitation, insolation and wind speed) and spring phenology on interannual changes in leaf coloring date (LCD) with the partial correlation analysis, and assessed the relative importance of phylogeny and native climate to LCD differences among species by using multivariate regression and phylogenetic eigenvector regression approach. The results showed that the effects of climate factors on interannual changes in LCD were more significant than spring phenology. In general, temperature played a more important role in cold regions (e.g. the northeast region), while the control of insolation on LCD was stronger in the warmer and wetter regions (e.g. the north, east and southwest regions). In addition, the effects of precipitation and wind speed were more evident in arid regions (e.g. the northwest region). We also found considerable effects of both native climate and phylogeny on the LCD differences among species, despite the contribution of native climate being almost 2~5 times greater than that of the phylogeny. Our findings confirmed and quantified the combined effects of climate, spring phenology and phylogeny on the autumn phenology of plants, which could help better understand the driving factors and influencing mechanism of plant phenology and provide a reference for the calibration and optimization of phenological models.
Genome-wide investigation and expression profiles of the NPF gene family provide insight into the abiotic stress resistance of Gossypium hirsutum
Authors: Liu Juanjuan , Wang Caixiang , Peng Jialuo , Ju Jisheng , Li Ying , Li Chaozhou , Su Junji
Published: January 2023

Membrane transporters encoded by NITRATE TRANSPORTER 1/PEPTIDE TRANSPORTER (NPF) genes, which play crucial roles in plant growth, development and resistance to various stresses, are involved in the transport of nitrate (NO3-) and peptides. In several plant species, NPF genes are involved in the resistance to abiotic stresses; however, whether the whole NPF gene family in cotton contributes to this resistance has not been systematically investigated. Here, 201 genes encoding NPF proteins with a peptide transporter (PTR) domain were confirmed in three different Gossypium species, namely, Gossypium hirsutum, Gossypium arboreum and Gossypium raimondii. The NPF proteins in these three Gossypium species and Arabidopsis thaliana were classified into three different subfamilies via phylogenetic analysis. Among the genes that encode these proteins, most GhNPF genes in the same subfamily contained similar gene structures and conserved domains. Predictions of the promoters of these genes revealed that the cis-acting elements included phytohormone- and light-responsive elements, indicating that some of these genes might be expressed in response to abiotic stress. Furthermore, 52 common potential candidate genes in 98 GhNPFs were predicted to exhibit specific spatiotemporal expression patterns in different tissues based on two RNA sequencing (RNA-seq) datasets. Finally, the gene expression profiles of abiotic stress indicated that 31 GhNPF genes were upregulated in at least one treatment period. Under abiotic stress for 12 and 24 h, the expression of GhNPF8 was upregulated upon cold treatment but downregulated with heat treatment, salt treatment and drought treatment. Furthermore, the expression of genes GhNPF8, GhNPF54 and GhNPF43 peaked at 6 h after heat and salt treatment. These results indicated that these genes exhibit underlying characteristics related to responses to abiotic stress. The verification of NPFs and analysis of their expression profiles in different tissues and in response to different abiotic stresses of cotton provide a basis for further studying the relationship between abiotic stress resistance and nitrogen (N) transport in cotton, as well as identifying candidate genes to facilitate their functional identification.
Heat stress decreased transpiration but increased evapotranspiration in gerbera
Authors: Yang Zaiqiang , Jiang Yuhan , Qiu Rangjian , Gong Xuewen , Agathokleous Evgenios , Hu Wei , Clothier Brent
Published: January 2023

Heat stress is a major constraint for plant production, and evapotranspiration is highly linked to plant production. However, the response mechanism of evapotranspiration to heat stress remains unclear. Here, we investigated the effects of heat stress during two main growth stages on transpiration and evapotranspiration of gerbera. Two levels of day/night temperature were adopted during the vegetative growth stage (VG) and the flowering bud differentiation stage (FBD), namely control (CK; 28/18 °C) and heat stress (HS; 38/28°C) levels. The duration of HS was set as 5, 10, 15, and 20 days, respectively. At the beginning of HS, hourly transpiration was mainly inhibited near noon. With continuation of HS, the duration and extent of inhibition of hourly transpiration increased. Daily transpiration rate was also markedly reduced by HS during the VG (18.9%-31.8%) and FBD (12.1%-20.3%) stages compared to CK. The decrease in the daily transpiration rate was greater for longer duration of heat stress. This reduction of transpiration was the main contributor to stomatal limitation at the beginning of HS, while additional inhibition of root activity, leaf area, and root biomass occurred under long-term HS. The daily transpiration rate could not recover after the end of HS (so-called recovery phase), except when HS lasted 5 days during the VG stage. Interestingly, daily evapotranspiration during HS was substantially increased during the VG (12.6%-24.5%) and FBD (8.4%-17.6%) stages as a result of more increased evaporation (100%-115%) than reduced transpiration. However, during the recovery phase, the daily evapotranspiration was markedly decreased at the VG (11.2%-22.7%) and FBD (11.1%-19.2%) stages. Hence, we suggest that disproportionate variation of transpiration and evaporation during HS, especially at the recovery phase, should be considered in various evapotranspiration models and climate scenarios projections.
Holacracy, a modern form of organizational governance predictors for person-organization-fit and job satisfaction
Authors: Weirauch Lena , Galliker Sibylle , Elfering Achim
Published: January 2023

This study compares illegitimate tasks and appreciation in traditional work organisations and holacracy work organisations based in Switzerland and Germany. In addition, the study tests whether the fit between employees and holacracy organisations depends on personality characteristics. Ninety-five employees working in holacratic companies participated in an online survey with standardised questionnaires on illegitimate tasks, Big Five personality dimensions, perceived holacracy satisfaction and person–organisation fit. For the comparison of illegitimate tasks and appreciation, a propensity-matching comparison group of people working in traditional companies was used. The results revealed significantly lower illegitimate tasks t(53) = −2.04, p < 0.05, with a lower level (2.49) in holacracy than in traditional work (2.78). Concerning appreciation, the results showed significantly higher values for holacratic (5.33) than for traditional work [4.14, t(53) = 4.86, p < 0.001]. Multiple linear regression of holacracy satisfaction on personality dimensions showed neuroticism (b = −4.72, p = 0.006) as a significant predictor. Agreeableness showed marginally significant results (b = 2.39, p = 0.06). This indicates that people scoring low on neuroticism and high in agreeableness may thrive better in holacracy organisations. Based on the results, theoretical and practical implications as for example implications for corporates hiring strategy, are discussed. Finally, this study presents numerous directions for future research.
Moral contamination: Perceptions of good (but not bad) deeds depend on the ethical history of the actor
Authors: Protzko John , Schooler Jonathan W.
Published: January 2023

In the majority of moral decision-making research, we are asked to consider the action of someone we know little about—an anonymous actor. This is inconsistent with our everyday judgments of the actions of others. Here we test the novel prediction of whether actions are considered as comparably virtuous or malignant when performed by a good person, an immoral person, or the standard anonymous actor. Across four sets of experiments (nine studies in total), we show that the moral status of the actor contaminates peoples’ evaluations of the virtue of their actions. Even without ulterior motives, people do not judge good acts consistently across actors. We also discover a dose–response relationship where the more immoral the actor has been in the past—the less credit they are given for a good action in the present. This process does not occur for good people performing bad acts, however. Bad acts are bad regardless of who commits them. These results give new insights into the way people evaluate the behaviors of others.
Well-being and mathematics achievement: What is the role of gender, instructional clarity, and parental involvement?
Authors: Wilson Fadiji Angelina , Reddy Vijay
Published: January 2023

Introduction

The aim of the present study was to explore the relationship between satisfaction with life and mathematics achievement among a nationally representative sample of Grade 9 learners in South Africa.

Methods

Using the Trends in Mathematics and Science Study (TIMSS 2019) based on a sample of 20,829 learners (females = 11,067 and males = 9,719), and employing structural equation modelling (SEM), we examined the nature of the relationship between satisfaction with life and mathematics achievement, considering the role of gender, parental involvement, and instructional clarity.

Results

Our findings showed that satisfaction with life is positively related to mathematics achievement, but is not moderated by gender. Additionally, instructional clarity contributes to, and is a partial mediator of, the relationship between life satisfaction and mathematics achievement. This suggests that greater instructional clarity is positively associated with high achievement in mathematics, over and above the relationship with satisfaction with life. By contrast, parental involvement negatively mediates this relationship, suggesting that mathematics achievement is negatively associated with certain forms of parental involvement, such as setting time aside for homework; and checking if homework is done.

Discussion

Given the tested linear relationship between life satisfaction, instructional clarity and mathematics achievement, the results of the study suggest that if wellbeing is improved and existing instructional practices are constantly reviewed, mathematics scores could be positively affected. In addition, the emerging finding on the negative role of parental involvement in the hypothesised mediated relationship suggests that learners could benefit from properly tailored, and government-sponsored, afterschool tutoring.
Drawing techniques as tools for the evaluation of scholastic integration and emotional components in primary and secondary school: A cross-sectional study
Authors: La Grutta Sabina , Piombo Marco Andrea , Riolo Martina , Spicuzza Vittoria , Cianciolo Umberto Maria , Andrei Federica , Trombini Elena , Epifanio Maria Stella
Published: January 2023

Introduction

In the last decades, many studies have emphasized emotion’s role in psycho-educational processes during childhood, such as scholastic integration. Emotional variables in childhood can be assessed through projective graphic techniques, as they allow children to use kinetic components of the draws to communicate emotions.

Method

1.757 couple of draws were collected, from primary school children (N = 1.270; F = 643 [50.6%]; Age = 8.6; SD = 1.31) and secondary school children (N = 487; F = 220 [45.2%]; Age = 11.72; SD = 0.70) and from eight schools in Sicily and over 60 different classrooms. The Drawn Stories Technique and the Classroom Draw were used to assess children’s current emotional state and scholastic integration.

Results

Pearson’s correlation showed significant relationships between the Drawn Stories Technique and both sex and age. In contrast, Classroom Drawing total score showed a significant relationship with the female sex but no significant relationship with age. Linear regression analysis, including sex and age as independent variables, showed that sex is a significant predictor of Negative Outcomes of the Drawn Stories Technique, while no effect of age was detected.

Discussion

These findings showed that adequate attention is needed to the learners’ emotional-affective world that influences their relationships and their vision within the class group. Although the drawing techniques alone seem to be not as such sufficient to explain children’s individual differences in the classroom on the whole, they could be helpful for the teacher to facilitate dialogues with children, modulate didactical materials, and detect and prevent some problems in group class functioning.
The impact of social media influencers’ bragging language styles on consumers’ attitudes toward luxury brands: The dual mediation of envy and trustworthiness
Authors: Feng Wenting , Chang Dihui , Sun Hongjie
Published: January 2023

On social media, luxury brand managers often use influencers’ bragging language as a marketing tool. As modesty is considered a virtue in the Chinese context, Chinese influencers tend to adopt a humblebragging language style. Research has examined the impact of bragging language styles on luxury brands and has found that humblebragging, which appears to be modest, has a negative influence on brand attitudes. From the perspective of social comparison theory, we proposed a dual mediation model of malicious envy and trustworthiness to reveal the internal mechanisms and moderating factors of the negative effects of humblebragging. The results of three experiments indicated that compared with straightforward bragging, humblebragging was more likely to elicit malicious envy and lower levels of trust in an influencer, resulting in negative attitudes toward the luxury brand endorsed. Moreover, this negative effect was stronger when the influencer lacked expertise or had high similarity with consumers. Our findings enrich the antecedents of social media influencer marketing and provide managers with implications for maximizing the effectiveness of influencer marketing by matching influencers with word-of-mouth content.
What role does mindfulness play in regulating fear of COVID-19 and associated mental health? The results of a cross-sectional study
Authors: Lee Kunhua , Lee Yu-Xuan , Cheng Yu-Tung
Published: January 2023

Objectives

The pandemic has greatly impacted people’s lives and mental health. Therefore, it is now especially important to help people maintain good mental health. The positive effects of mindfulness-based practices on mental health have been demonstrated previously. However, no consensus has yet been reached on the potential mechanisms of mindfulness. This study adopted the two-component model of mindfulness to explain the relationships between fear of COVID-19, and mental health. We proposed the following hypothetical model: (1) fear of COVID-19 could affect orientation to experience; (2) orientation to experience could affect mental health. Directly; (3) fear of COVID-19 could mental health directly; (4) orientation to experience could be a mediator between fear of COVID-19 and mental health.

Methods

We conducted an online survey in the present study. Three hundred and forty-four respondents were recruited to participate in the present study. After informed consent, they completed the questionnaires on the websites. The participants were asked to complete a questionnaire including the Beck Depression Inventory-II, Beck Anxiety Inventory, the Taiwan version of the Five Facet Mindfulness Questionnaire, and the Fear of COVID-19 Scale. Descriptive analysis and structural equation modeling were used to analyze the data and examine the goodness-of-fit indices.

Results

Our results not only showed orientation to experience playing as a mediator between fear of COVID-19 and mental health; but also confirmed the roles of nonjudgment and nonreactivity in regulating emotions.

Conclusion

Experimentation and longitudinal study could be applied to examine the roles of nonjudgment and nonreactivity in the future.
Personality traits and transition to psychosis one year after the first assessment
Authors: De Salve Francesca , Rossi Chiara , Cavalera Cesare , Malvini Lara , Barbera Simona , Tagliabue Sofia , Percudani Mauro , Oasi Osmano
Published: January 2023

Introduction

Several studies have identified ultra-high-risk criteria that may characterize an at-risk mental state and predict the transition of psychotic evolution. Personality traits may play a crucial role in this process.

Aims

The current study aims to: (a) explore the evolution of an initial diagnosis over 12 months; (b) assess differences in social and occupational functioning; (c) identify common (trans-diagnostic) personality traits of psychotic risk.

Methods

The sample includes 97 (44 males and 53 females) young adults. They completed an assessment that consists of socio-demographic data, the Social and Occupational Functioning Scale, the Early Recognition Inventory-retrospective assessment onset of schizophrenia, and the Personality Inventory for DSM-5 (PID-5). According to the tests’ assessment, the sample was divided into three different groups: Ultra-High Risk (UHR), At-Risk, and Not at risk. One year after the first evaluation, psychiatrists administered the QuickSCID-5 to verify the diagnostic trajectories of the sample.

Results

Overall, the most prevalent category diagnoses were anxiety/depression, personality disorders, and psychosis. Specifically, the most common diagnosis in the UHR group was psychosis. Moreover, in the UHR group, the social and occupational functioning score was the lowest. In terms of differences in PID-5 personality traits, the At-risk and UHR groups scored highest in detachment and disinhibition. No statistically significant differences were found between the groups for negative affectivity, antagonism, and psychoticism traits.

Conclusion

Results obtained by the current study should be considered an attempt to better understand the diagnostic trajectories and trans-diagnostic personality traits in a group of young help-seekers, specifically in UHR. Findings highlight both the importance of diagnosis and personality traits evaluation to customize a specific intervention based on the level of psychotic risk. Clinical suggestions are reported.
The role of self-regulatory control processes in understanding aggressive ideations and behaviors: An experience sampling method study
Authors: Plessen Kerstin Jessica , Constanty Lauriane , Ranjbar Setareh , Turri Fiorella , Miano Giorgia , Lepage Caroline , Urben Sébastien
Published: January 2023

Introduction

In this study, we aimed to examine the association between aggressive ideations and aggressive behaviors in everyday life, as well as the role of processes related to self-regulatory control (i.e., self-control, ego depletion, and emotional states), using experience sampling methods (ESM).

Methods

A total of 62 male adolescents performed a baseline measure of aggression, violent ideations (trait level), and ESM assessments, including four measures per day during nine consecutive days.

Results

At a state level, aggressive ideations were associated with higher negative emotions during the previous day as well as with lower self-control and stronger anger rumination at the moment. Aggressive behaviors were related to higher anger rumination at the moment and to the manifestation of higher intensity of aggressive ideations derived in the previous measure. Higher self-control was related to a lower probability of aggressive behavior.

Discussion

This study highlights the temporal link between aggressive ideations and behaviors in everyday life as well as the role of self-control in understanding aggressivity in the lap of time. Furthermore, we observed that expressions of anger (i.e., reactivity, as well as rumination) were central in the understanding of aggressive ideations and behaviors in the everyday life (i.e., at within-person variability at the state level).
Violence, neurocognitive function and clinical correlates in patients with schizophrenia
Authors: Yi Yun , Huang Yuanyuan , Chen Qiang , Yang Hanlun , Li Hehua , Feng Yangdong , Feng Shixuan , Zhou Sumiao , Li Zezhi , Wu Fengchun
Published: January 2023

Background

Schizophrenia patients with violent behavior are a severe public health concern, but the correlates of this violent behavior are unknown. Additionally, the relationship between neurocognitive function and violent behavior in Chinese patients with schizophrenia has not yet been investigated.

Methods

A total of 337 schizophrenia inpatients were recruited. The Positive and Negative Syndrome Scale (PANSS) was used to assess psychopathological symptoms. Neurocognitive functioning was evaluated using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).

Results

The percentage of violent behavior was 10.4% in patients with schizophrenia. Patients with violent behavior had higher PANSS-positive, excited, and total subscale scores than patients who did not show violent behavior. Patients with violent behavior also had lower RBANS language, semantic fluency, and total subscale scores. Gender (OR = 0.066∼0.819, p = 0.023), illness duration (OR = 0.876∼0.971, p = 0.002), smoking (OR = 1.127∼2.950, p = 0.014), the PANSS positive subscale (OR = 1.050∼1.197, p = 0.001), and the RBANS language subscale (OR = 0.927∼0.987, p = 0.005) significantly contributed to the development of violent behavior in schizophrenia patients.

Conclusion

Our findings revealed that cognitive and clinical assessments should be considered in comprehensive assessments of future risks of violence in schizophrenia patients.
Prediction of Chinese clients’ satisfaction with psychotherapy by machine learning
Authors: Yao Lijun , Wang Ziyi , Gu Hong , Zhao Xudong , Chen Yang , Liu Liang
Published: January 2023

Background

Effective psychotherapy should satisfy the client, but that satisfaction depends on many factors. We do not fully understand the factors that affect client satisfaction with psychotherapy and how these factors synergistically affect a client’s psychotherapy experience.

Aims

This study aims to use machine learning to predict Chinese clients’ satisfaction with psychotherapy and analyze potential outcome contributors.

Methods

In this cross-sectional investigation, a self-compiled online questionnaire was delivered through the WeChat app. The information of 791 participants who had received psychotherapy was used in the study. A series of features, for example, the participants’ demographic features and psychotherapy-related features, were chosen to distinguish between participants satisfied and dissatisfied with the psychotherapy they received. With our dataset, we trained seven supervised machine-learning-based algorithms to implement prediction models.

Results

Among the 791 participants, 619 (78.3%) reported being satisfied with the psychotherapy sessions that they received. The occupation of the clients, the location of psychotherapy, and the form of access to psychotherapy are the three most recognizable features that determined whether clients are satisfied with psychotherapy. The machine-learning model based on the CatBoost achieved the highest prediction performance in classifying satisfied and psychotherapy clients with an F1 score of 0.758.

Conclusion

This study clarified the factors related to clients’ satisfaction with psychotherapy, and the machine-learning-based classifier accurately distinguished clients who were satisfied or unsatisfied with psychotherapy. These results will help provide better psychotherapy strategies for specific clients, so they may achieve better therapeutic outcomes.
Predictors of health state utility values using SF-6D for Chinese adult patients with β-thalassemia major
Authors: Zhang Runqi , Zhang Shuo , Ming Jing , Xie Jing , Liu Baoguo , Chen Cuiqian , Sun Xiaojie , Zhen Xuemei
Published: January 2023

Background

Patients with β-thalassemia major (β-TM), predominantly adult patients, are associated with physical, mental, and social problems, that result in decreased quality of life (QoL). However, there is a paucity of data on QoL and health status utility (HSU) among adult patients with β-TM in mainland China. Our study aimed to evaluate the QoL by short form 36 questionnaire (SF-36) of adult patients with β-TM in mainland China and to estimate their HSU by SF-6D. In addition, we aimed to identify predictors of HSU.

Methods

In this cross-sectional descriptive study, a total of 75 adult patients with β-TM were included by the snowball sampling method that applied involving seven provinces with a relatively high prevalence of thalassemia across mainland China between September 1, 2021 and January 31, 2022. The collected information included social-demographic characteristics, health conditions, treatment, social support (social support rating scale), caregiver burden (Zarit burden interview), and QoL (SF-36). HSU scores were calculated for each adult patient from their SF-36 responses using the SF-6D algorithm with Hong Kong's tariff. The frequency of participants' responses to the SF-6D for each item of the options was described. Mean HSU scores between different subgroups were calculated. Ordinary least squares (OLS) regression modeling was performed to identify factors associated with HSU.

Results

A total of 75 adult patients with β-TM were included in this study. The mean SF-36 score was 50.2 ± 10.70, of which physical and mental scores were 47.57 ± 11.28 and 52.85 ± 14.21, respectively. In addition, the mean SF-6D utility score was estimated to be 0.598 ± 0.112, ranging from 0.391 to 0.962. Univariate analyses showed that interruption of iron chelation treatment significantly affected HSU values (P = 0.038); diagnosis with comorbidity very slightly affected HSU values (P = 0.0996). In the multivariate analysis, diagnosis with comorbidity (P = 0.042) was significantly negatively associated with HSU values; the minimum pre-transfusion hemoglobin concentration (P = 0.047) and social support (P = 0.068) were positively associated with HSU values.

Conclusion

This study presents poor QoL and HSU outcomes in Chinese adult patients with β-TM. The study also highlights the importance of social support and treatment compliance, which can increase hemoglobin content and reduce comorbidities, further to ensure the QoL of patients. These findings can be used for future clinical and economic studies.
Associations between depression and the incident risk of obesity in southwest China: A community population prospective cohort study
Authors: Liu Tao , Wu Bo , Yao Yuntong , Chen Yun , Zhou Jie , Xu Kelin , Wang Na , Fu Chaowei
Published: January 2023

Objective

This study aimed to describe the incidence of obesity and investigate associations between depression and the risk of incident obesity among residents in Southwest China.

Methods

A 10-year prospective cohort study of 4,745 non-obese adults was conducted in Guizhou, southwest China from 2010 to 2020. Depression was assessed by the Patient Health Questionnaire-9 (PHQ-9) while the obesity was identified by waist circumference (WC) and/or body mass index (BMI). Cox proportional hazard models were used to estimate hazard ratios (HR), and 95% confidence intervals (CIs) of depression and incident obesity.

Results

A total of 1,115 incident obesity were identified over an average follow-up of 7.19 years, with an incidence of 32.66 per 1,000 PYs for any obesity, 31.14 per 1,000 PYs and 9.40 per 1,000 PYs for abdominal obesity and general obesity, respectively. After adjustment for potential confounding factors, risks of incident abdominal obesity for subjects with minimal (aHR: 1.22, 95% CI: 1.05, 1.43), and mild or more advanced depression (aHR: 1.27, 95% CI: 1.01, 1.62) were statistically higher than those not depressed, while there was no significant association with incident general obesity. The risks of any incident obesity among subjects with minimal (aHR: 1.21, 95% CI: 1.04, 1.40), mild or more advanced depression (aHR: 1.30, 95% CI: 1.03, 1.64) were significantly higher than those not depressed and positive association was found for PHQ score per SD increase (aHR: 1.07, 95%CI: 1.01, 1.13), too. The association was stronger significantly in Han Chinese (minimal: aHR: 1.27, 95% CI: 1.05, 1.52; mild or more advanced: aHR: 1.70, 95% CI: 1.30, 2.21) and farmers (minimal: aHR: 1.64, 95% CI: 1.35, 2.01; mild or more advanced: aHR: 1.82, 95% CI: 1.32, 2.51).

Conclusion

Depression increased the risk of incident obesity among adults in Southwest China, especially among Han Chinese and farmers. This finding suggests that preventing and controlling depression may benefit the control of incident obesity.
Usability of self-reported assessment of work functioning in municipal occupational rehabilitation teams: A qualitative study
Authors: Momsen Anne-Mette Hedeager , Tonnesen Merete , Zwicky-Hauschild Birgitte , Nielsen Claus Vinther , Escorpizo Reuben , Langagergaard Vivian , Stapelfeldt Christina Malmose
Published: January 2023

Aims

This study aimed to explore (1) whether self-reported assessment on work-related functioning, workability, return-to-work (RTW) self-efficacy, and expectation was useful in the professionals’ assessment of sick-listed workers and could guide referral to interventions and (2) whether self-reporting in addition to “usual practice” could improve the RTW dialog and involvement in case management.

Methods

The qualitative study took place in two municipal job centers in 2021. The assessment was based on the Work Rehabilitation Questionnaire, RTW-Self-efficacy Scale-19, and single items of self-rated health, workability, and RTW expectations. Sick-listed workers (n = 36) were interviewed by telephone. Three focus-group interviews were conducted with professionals who had used the questionnaire. Data were coded and analyzed thematically.

Results

Three themes with seven subthemes emerged: (1) accessibility; (2) one tool in the RTW toolbox (subthemes: a supplementary tool, a tool for reflection, facilitating interdisciplinary communication, and enhancing active participation); and (3) the value of “ticking boxes” (subthemes: good days, bad days, the issue of power, and the cultural meaning of words).

Conclusion

The professionals would not recommend the present questionnaire for use during their rehabilitation team meeting for assessment, interdisciplinary communication, or choice of interventions. However, using the parts assessing RTW self-efficacy and expectation combined with a dialog may be of value early in the RTW process. The self-reporting assessment tool was perceived to be meaningful to some sick-listed workers, as it provided reflections on important aspects of the RTW process. Some workers believed that it might contribute to the rehabilitation team, and thus, it could improve their involvement.