bluuebunny/crossref_metadata_2025 huggingface dataset:
Highly Selective Dehydrochlorination of 1,1,1,2‐Tetrafluoro‐2‐chloropropane to 2,3,3,3‐Tetrafluoropropene over Alkali Metal Fluoride Modified MgO Catalysts
Authors: Mao Wei , Bai Yanbo , Wang Wei , Wang Bo , Xu Qiang , Shi Lei , Li Chen , Lu Jian
Published: November 2016

Gas‐phase selective dehydrochlorination of 1,1,1,2‐tetrafluoro‐2‐chloropropane (HCFC‐244bb) to 2,3,3,3‐tetrafluoropropene was investigated over various K and Cs halides modified MgO catalysts. The reaction proceeded in the absence of additives such as air and HF. High dehydrochlorination selectivity (>97 %) with moderate activity (>14 μmol h−1 m−2) was achieved on KF and CsF modified MgO catalysts, in which the dehydrofluorination process was inhibited. Compared with alkali metal modified MgO, the dehydrofluorination product, 2‐chloro‐3,3,3‐trifluoropropene increased over Zr and Al modified MgO and fluorinated MgO catalysts (sel. of 20–76 %). XRD and energy‐dispersive‐spectrometry results revealed that surface chlorination and fluorination occurred on the MgO‐based catalysts during the reaction. Introducing alkali metal fluorides into the catalyst can reduce the fluorination of MgO and the deposition of chlorine species, thus improving the dehydrochlorination activity and stability of MgO. The NH3 temperature‐programmed desorption (TPD) results show that decreasing the surface acidity of catalyst benefits the dehydrochlorination of HCFC‐244bb, whereas the relationship between the basicity of the catalyst and its dehydrohalogenation behavior is complicated as shown by the CO2 TPD results. According to the hard–soft acid–base principle, the dehydrohalogenation selectivity can be correlated with the surface chemical hardness of the catalyst.
Effects of Solvents on the Electrochemical Performance of LiFePO4/C Composite Electrodes
Authors: Wang Guixin , Kang Hanchang , Chen Miao , Yan Kangping , Hu Xueshan , Cairns Elton J.
Published: November 2016

The electrolyte, a key component for the successful operation of energy materials, is greatly affected by its solvents. The influence of solvents on the electrochemical performance of a LiFePO4/C composite cathode was investigated at various operating temperatures. The reaction kinetics of the LiFePO4/C composite electrode, including changes of rate capability, redox potential, polarization degree, electrode reaction process, exchange current densities, and activation energies, were evaluated using various techniques. The composition and volume ratio of solvents greatly affect the electrode kinetics. In the mixed solvents of ethylene carbonate (EC), dimethyl carbonate (DMC) and ethyl methyl carbonate (EMC), EMC is beneficial for the room temperature performance, while the substitution of 20 vol % of EMC by ethyl acetate (EA) is good for the low temperature performance. When 30 vol % of DMC is substituted by 10 vol % of EMC and 20 vol % of EA, the exchange current density increases from 0.022 to 0.038 mA cm−2 at −20 °C, while the activation energy of the charge‐transfer process decreases from 48.36 to 33.01 kJ mol−1. Possible mechanisms for improving the electrochemical performance using different solvents have been analyzed. These results are significant for the exploration of appropriate electrolytes for the extensive applications of LiFePO4/C composite electrodes.
Three‐Dimensional Hierarchically Mesoporous ZnCo2O4 Nanowires Grown on Graphene/Sponge Foam for High‐Performance, Flexible, All‐Solid‐State Supercapacitors
Authors: Moon In Kyu , Yoon Seonno , Oh Jungwoo
Published: November 2016

To achieve high energy storage on three‐dimensional (3D) structures at low cost, materials with high power and long cycle life characteristics have to be developed. We synthesized ZnCo2O4/reduced graphene oxide (rGO) binary composites in commercial sponges. ZnCo2O4 nanosheets were grown on the surface of GO/sponge through a hydrothermal reaction. The resulting flexible, free‐standing ZnCo2O4/rGO/sponge electrodes were used as the electrodes in a symmetric supercapacitor. ZnCo2O4/rGO/sponge electrodes have a large specific capacitance of 1116.6 F g−1 at a scan rate of 2 mV s−1 in aqueous electrolyte. The all‐solid‐state flexible supercapacitor is assembled based on ZnCo2O4/rGO/sponge electrodes, which show excellent electrochemical performances with a specific capacitance of 143 F g−1 at a current density of 1 A g−1. The as‐fabricated supercapacitor also exhibits excellent cycling stability (93.4 % capacitance retention after 5000 cycles) and exceptional mechanical flexibility. These results demonstrate the potential of ZnCo2O4/rGO/sponge as an electrode in flexible, high‐performance supercapacitors.
Peptide‐Stabilized, Fluorescent Silver Nanoclusters: Solid‐Phase Synthesis and Screening
Authors: Gregersen Simon , Vosch Tom , Jensen Knud J.
Published: November 2016

Few‐atom silver nanoclusters (AgNCs) can exhibit strong fluorescence; however, they require ligands to prevent aggregation into larger nanoparticles. Fluorescent AgNCs in biopolymer scaffolds have so far mainly been synthesized in solution, and peptides have only found limited use compared to DNA. Herein, we demonstrate how solid‐phase methods can increase throughput dramatically in peptide ligand screening and in initial evaluation of fluorescence intensity and chemical stability of peptide‐stabilized AgNCs (P‐AgNCs). 9‐Fluorenylmethyloxycarbonyl (Fmoc) solid‐phase peptide synthesis on a hydroxymethyl‐benzoic acid (HMBA) polyethylene glycol polyacrylamide copolymer (PEGA) resin enabled on‐resin screening and evaluation of a peptide library, leading to identification of novel peptide‐stabilized, fluorescent AgNCs. Using systematic amino acid substitutions, we synthesized and screened a 144‐member library. This allowed us to evaluate the effect of length, charge, and Cys content in peptides used as ligands for AgNC stabilization. The results of this study will enable future spectroscopic studies of these peptide‐stabilized AgNCs for bioimaging and other applications.
Simple Synthesis of Fluorinated Graphene: Thermal Exfoliation of Fluorographite
Authors: Jankovský Ondřej , Mazánek Vlastimil , Klímová Kateřina , Sedmidubský David , Kosina Jiří , Pumera Martin , Sofer Zdeněk
Published: November 2016

Fluorinated graphene can be prepared directly by thermal exfoliation of fluorographite. The exfoliation was performed in a dynamic nitrogen atmosphere at various temperatures and the exfoliation products were analysed in detail by GC‐MS. The structure and properties of all prepared fluorinated graphenes with various contents of fluorine were characterized by a number of analytical techniques. The results show both the dependence of fluorine concentration on exfoliation temperature and the suitability of this method for the synthesis of graphene with controlled concentration of fluorine. The high‐temperature exfoliated fluorographite exhibits a high heterogeneous electron transfer rate and excellent catalytic properties towards the oxygen reduction reaction. These synthetic procedures can open a simple way for the synthesis of fluorinated graphene‐based devices with tailored properties.
Understanding the Role of Dispersion in Frustrated Lewis Pairs and Classical Lewis Adducts: A Domain‐Based Local Pair Natural Orbital Coupled Cluster Study
Authors: Bistoni Giovanni , Auer Alexander A. , Neese Frank
Published: November 2016

The interaction of Lewis acids and bases in both classical Lewis adducts and frustrated Lewis pairs (FLPs) is investigated to elucidate the role that London dispersion plays in different situations. The analysis comprises 14 different adducts between tris(pentafluorophenyl)borane and a series of phosphines, carbenes, and amines with various substituents, differing in both steric and electronic properties. The domain‐based local pair natural orbital coupled‐cluster (DLPNO‐CCSD(T)) method is used in conjunction with the recently introduced local energy decomposition (LED) analysis to obtain state‐of‐the‐art dissociation energies and, at the same time, a clear‐cut definition of the London dispersion component of the interaction, with the ultimate goal of aiding in the development of designing principles for acid/base pairs with well‐defined bonding features and reactivity. In agreement with previous DFT investigations, it is found that the London dispersion dominates the interaction energy in FLPs, and is also remarkably strong in Lewis adducts. In these latter systems, its magnitude can be easily modulated by modifying the polarizability of the substituents on the basic center, which is consistent with the recently introduced concept of dispersion energy donors. By counteracting the destabilizing energy contribution associated with the deformation of the monomers, the London dispersion drives the stability of many Lewis adducts.
ChemInform Abstract: Er1.33Pt3Ga8: A Modulated Variant of the Er4Pt9Al24‐Structure Type.
Authors: Oswald Iain W.H. , Gourdon Olivier , Bekins Amy , Evans Jess , Treadwell LaRico J. , Chan Julia Y. , Macaluso Robin T.
Published: November 2016

Single crystals of Er1.33Pt3Ga8 are grown in a molten Ga flux from a 1.33:1:15 molar mixture of Er, Pt, and Ga (Al2O3 crucible in evacuated silica tubes, 1150 °C, 7 h).
ChemInform Abstract: A Bottom‐Up Strategy for Exfoliation‐Free Synthesis of Soluble α‐Ni(OH)2 Monolayer Nanosheets on a Large Scale.
Authors: Ma Wenle , Wang Li , Xue Junying , Cui Hongtao
Published: November 2016

In contrast to a multiple step layer‐exfoliation process (“bottom‐up” mechanism), α‐Ni(OH)2 monolayer nanosheets are prepared by dissolving NiCl2 in pure EtOH followed by NaOH addition (60 °C, 24 h), vacuum filtration, washing, and drying in air at 80 °C.
ChemInform Abstract: A Facile One‐Pot Solvothermal Synthesis of CoFe2O4/RGO and Its Excellent Catalytic Activity on Thermal Decomposition of Ammonium Perchlorate.
Authors: Chen Teng , Du Ping , Jiang Wei , Liu Jie , Hao Gazi , Gao Han , Xiao Lei , Ke Xiang , Zhao Fengqi , Xuan Chunlei
Published: November 2016

CoFe2O4/reduced graphene (RGO) hybrids are fabricated by solvothermal reaction of CoCl2 and FeCl3 which are given to an ultrasonicated suspension of graphene oxide (GO) in ethylene glycol to which sodium citrate and NaOAc are given to stabilize the suspension (autoclave, 180 °C, 12 h).
ChemInform Abstract: Synthesis, Crystal Structure and Magnetic Properties of an Azido‐Bridged Complex [C6H11NH3]2 [Mn(N3)4].
Authors: Qian Kun , Yang Chang‐Xin
Published: November 2016

Colorless block‐shaped crystals of the title compound are prepared from aqueous solutions of Mn(NO3)2, NaN3, and cyclohexylamine hydrochloride (room temperature, 2 d, 50% yield).
ChemInform Abstract: Lanthanoid Template Isolation of the α‐1,5 Isomer of Dicobalt(II)‐Substituted Keggin Type Phosphotungstates: Syntheses, Characterization, and Magnetic Properties.
Authors: Gupta Rakesh , Hussain Firasat , Sadakane Masahiro , Kato Chisato , Inoue Katsuya , Nishihara Sadafumi
Published: November 2016

The new compounds (IVa—j) are characterized by single crystal XRD, FT‐IR spectroscopy, electrospray ionization mass spectrometry, and magnetic measurements.
ChemInform Abstract: [Mn(dien)2]2 [SbSe4Cu(μ2‐Se4)]: A Heterometallic Polyselenide Containing a Chelating μ2‐Se4.
Authors: Wang Yu‐Long , Feng Mei‐Ling , Wang Kai‐Yao , Li Jian‐Rong , Huang Xiao‐Ying
Published: November 2016

Single crystals of [Mn(dien)2]2 [SbSe4Cu(μ2‐Se4)] (dien: diethylenetriamine) are prepared by solvothermal reaction of Cu, Sb, Mn(OAc)2, and Se in dien (autoclave, 145 °C, 6 d; ≈3% yield).
ChemInform Abstract: Magnetic Nanoparticles‐Supported Chiral Catalyst with an Imidazolium Ionic Moiety: An Efficient and Recyclable Catalyst for Asymmetric Michael and Aldol Reactions.
Authors: Ying Anguo , Liu Shuo , Li Zhifeng , Chen Gang , Yang Jianguo , Yan Hua , Xu Songlin
Published: November 2016

The reusable catalyst is successfully used for both title processes and affords the products with high yields and excellent enantio‐/diastereoselectivity.
ChemInform Abstract: Direct Nucleophilic Difluoromethylation of Carbonyl Compounds.
Authors: Deng Zuyong , Lin Jin‐Hong , Cai Ji , Xiao Ji‐Chang
Published: November 2016

The reaction between aryl aldehydes with a suitable difluoromethyl phosphonium salt delivers secondary alcohols containing an α‐CF2H group in high yields.
ChemInform Abstract: C—C Coupling of Benzyl Fluorides Catalyzed by an Electrophilic Phosphonium Cation.
Authors: Zhu Jiangtao , Perez Manuel , Stephan Douglas W.
Published: November 2016

The activation and cleavage of benzyl fluorides by the electrophilic organofluorophosphonium catalyst, [(C6F5)3PF] [B(C6F5)4], is reported and used for the preparation of 1,1‐diarylalkanes and substituted aryl homoallylic alkenes.
ChemInform Abstract: AIBN‐Promoted Amidation of Anilines with 1, 3‐Diketones via Oxidative Cleavage of C—C Bond under Aerobic Conditions.
Authors: Rao Sadu Nageswara , Mohan Darapaneni Chandra , Adimurthy Subbarayappa
Published: November 2016

A metal‐ and peroxide‐free N‐acylation of anilines with 1,3‐diketones with oxygen as oxidant yields the corresponding N‐aryl amides under mild conditions.
ChemInform Abstract: Template Catalysis by Metal—Ligand Cooperation. C—C Bond Formation via Conjugate Addition of Non‐Activated Nitriles under Mild, Base‐Free Conditions Catalyzed by a Manganese Pincer Complex.
Authors: Nerush Alexander , Vogt Matthias , Gellrich Urs , Leitus Gregory , Ben‐David Yehoshoa , Milstein David
Published: November 2016

The title transformation proves efficient for the Michael addition of non‐activated aliphatic nitriles onto α,β‐unsaturated carbonyl compounds, including ester and cyclic or acyclic keto derivatives.
ChemInform Abstract: Chiral N‐Heterocyclic Carbene Ligand Enabled Nickel(0)‐Catalyzed Enantioselective Three‐Component Couplings as Direct Access to Silylated Indanols.
Authors: Ahlin Joachim S. E. , Cramer Nicolai
Published: November 2016

The title reaction between norbornene derivatives, aromatic aldehydes, and silanes provides silyl protected indanol scaffolds as single diastereomers with high enantiomeric excess.
ChemInform Abstract: Catalytic Enantioselective Addition of Methyltriisopropoxititanium to Aldehydes.
Authors: Veguillas Marcos , Sola Ricard , Fernandez‐Ibanez M. Angeles , Macia Beatriz
Published: November 2016

The efficient catalysts (Ia) and (Ib) render possible the preparation of various chiral methyl carbinols from aromatic and aliphatic aldehydes.
ChemInform Abstract: Rhodium‐Catalyzed Geminal Oxyfluorination and Oxytrifluoro‐Methylation of Diazocarbonyl Compounds.
Authors: Yuan Weiming , Eriksson Lars , Szabo Kalman J.
Published: November 2016

Stable and easily accessible benziodoxole reagents are used as fluorine source in reactions of aromatic and aliphatic diazocarbonyl compounds with a variety of alcohols, phenol, and carboxylic acids.
ChemInform Abstract: Metal‐Free Amidation of Acids with Formamides and T3P®.
Authors: Bannwart Linda , Abele Stefan , Tortoioli Simone
Published: November 2016

A simple one‐pot reaction of carboxylic acids with N,N‐dialkylformamides yields N,N‐dialkyl carboxamides.
ChemInform Abstract: Carbene‐Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters.
Authors: Chen Xingkuan , Fong Jacqueline Zi Mei , Xu Jianfeng , Mou Chengli , Lu Yunpeng , Yang Song , Song Bao‐An , Chi Yonggui Robin
Published: November 2016

A scalable procedure for the title transformation of a broad range of α,α‐disubstituted carboxylic esters is developed which delivers the products in often very high yields and with very high enantiomeric purity.
ChemInform Abstract: Regioselective Sulfonation of Aromatic Compounds over 1,3‐Disulfonic Acid Imidazolium Chloride under Aqueous Media.
Authors: Moosavi‐Zare Ahmad Reza , Zolfigol Mohammad Ali , Noroozizadeh Ehsan
Published: November 2016

The sulfonation reagent can be regenerated.
ChemInform Abstract: γ‐Selective Allylation of (E)‐Alkenylzinc Iodides Prepared by Reductive Coupling of Arylacetylenes with Alkyl Iodides.
Authors: Zhurkin Fedor E. , Hu Xile
Published: November 2016

A wide range of 1,4‐dienes is highly γ‐selectively obtained in the presence of a copper catalyst.
ChemInform Abstract: Selective Rhodium‐Catalyzed Hydroformylation of Alkynes to α,β‐Unsaturated Aldehydes with a Tetraphosphoramidite Ligand.
Authors: Zhang Zongpeng , Wang Qian , Chen Caiyou , Han Zhengyu , Dong Xiu‐Qin , Zhang Xumu
Published: November 2016

The reaction tolerates diaryl as well as dialkyl substituted alkynes.
ChemInform Abstract: Highly Enantioselective Iridium‐Catalyzed Hydrogenation of Cyclic Enamides.
Authors: Salomo Ernest , Orgue Silvia , Riera Antoni , Verdaguer Xavier
Published: November 2016

The MaxPHOX/Ir catalyst system (MPI) provides the highest selectivity ever reported for the reduction of cyclic enamides derived from α‐ and β‐tetralones.
ChemInform Abstract: Dimethyl Sulfoxide and N‐Iodosuccinimide Promoted 5‐Exo‐dig Oxidative Cyclization of Yne‐Tethered Ynamide: Access to Pyrrolidones and Spiro‐Pyrrolidones.
Authors: Prabagar B. , Nayak Sanatan , Prasad Rangu , Sahoo Akhila K.
Published: November 2016

The scalable title cyclization offers access to variously functionalized pyrrolidinone derivatives.
ChemInform Abstract: Organocatalytic Azomethine Imine‐Olefin Click Reaction: High‐Yielding Stereoselective Synthesis of Spiroindane‐1,3‐dione‐pyrazolidinones.
Authors: Ramachary Dhevalapally B. , Prabhakar Reddy T. , Suresh Kumar A.
Published: November 2016

The drug‐like products are formed in high yields and with often excellent diastereoselectivities.
ChemInform Abstract: Highly Regiocontrolled and Stereocontrolled Syntheses of Polysubstituted Aminocyclohexanes: Mild Inverse‐Electron‐Demand Diels—Alder Cycloadditions of Electrophilic 2‐Pyridones.
Authors: Conyers Ryan C. , Mazzone Jennifer R. , Siegler Maxime A. , Posner Gary H.
Published: November 2016

High endo‐selectivity for the inverse‐electron demand Diels—Alder reaction of 2,6‐dichlor‐4‐trifluoromethylphenylsulfonyl substituted 2‐pyridone with benzyl vinyl ether is achieved by formation of a zinc complex of the pyridone with catalytic amounts of ZnBr2.
ChemInform Abstract: A Bulky Thiyl‐Radical Catalyst for the [3 + 2] Cyclization of N‐Tosyl Vinylaziridines and Alkenes.
Authors: Hashimoto Takuya , Takino Kohei , Hato Kazuki , Maruoka Keiji
Published: November 2016

A thiyl‐radical‐catalyzed cyclization reaction of N‐tosyl vinylaziridines and alkenes is developed as a new synthetic method for the generation of substituted pyrrolidines.
ChemInform Abstract: Palladium‐Catalyzed Carbonylation of Indoles Using Aryl Formates as Bifunctional Reagents: A Route to Indol‐3‐yl Aryl Ketones.
Authors: Gu Li‐Jun , Wang Yu‐Shen , Zhang Hong‐Tao , Tang Huai‐Jun , Li Gan‐Peng , Yuan Ming‐Long
Published: November 2016

The method allows the preparation of various title compounds under CO‐free conditions.
ChemInform Abstract: Regioselective Michael Addition of Anthrone to Methyleneindolinones.
Authors: Zhao Huaili , Wang Xiaoxiao , Wang Liang , Xiao Jian
Published: November 2016

A regioselective conjugate addition reaction of anthrone to methyleneindolinones furnishes oxindole‐anthrone hybrid compounds in high yields and diastereoselectivities.
ChemInform Abstract: Thermal 1,3‐Dipolar Cycloaddition Reaction of Azomethine Imines with Active Esters.
Authors: He Liwenze , Liu Lin , Han Runfeng , Zhang Weiwei , Xie Xingang , She Xuegong
Published: November 2016

as a straightforward synthetic pathway to bioactive pyrazolidinones
ChemInform Abstract: Solution to the C3—Arylation of Indazoles: Development of a Scalable Method.
Authors: Basu Kallol , Poirier Marc , Ruck Rebecca T.
Published: November 2016

The title transformation is achieved following a Negishi coupling protocol which tolerates variously functionalized aryl and hetaryl bromides.
ChemInform Abstract: Catalyst‐Controlled Switch of Regioselectivity in the Asymmetric Allylic Alkylation of Oxazolones with MBHCs.
Authors: Zhu Gongming , Yang Junxian , Bao Guangjun , Zhang Ming , Li Jing , Li Yiping , Sun Wangsheng , Hong Liang , Wang Rui
Published: November 2016

The SN2′—SN2′reaction catalyzed by a quinine‐derived base produces γ‐selective secondary allylic oxazolone derivatives, whereas the addition—elimination reaction catalyzed by an amino acid‐derived bifunctional urea catalyst provides β‐selective primary adducts.
ChemInform Abstract: FeF3‐Catalyzed MCR in PEG‐400: Ultrasound Assisted Synthesis of N‐Substituted 2‐Aminopyridines.
Authors: Kumar Reddy Dinne Naresh , Chandrasekhar Kothapalli Bannoth , Siva Ganesh Yaddanapudi Sesha , Reddy G. Rajeshwar , Kumar J. Pradeep , Kapavarapu Ravi Kumar , Pal Manojit
Published: November 2016

A novel one‐pot synthesis of highly functionalized pyridines is accomplished by an ultrasound assisted multi‐component reaction.
ChemInform Abstract: Cp*CoIII‐Catalyzed C(sp3)—H Bond Amidation of 8‐Methylquinoline.
Authors: Barsu Nagaraju , Rahman Md. Atiur , Sen Malay , Sundararaju Basker
Published: November 2016

Various title compounds are treated with oxazolones in the absence of any external oxidant.
ChemInform Abstract: Potassium tert‐Butoxide‐Promoted Synthesis of 1‐Aminoisoquinolines from 2‐Methylbenzonitriles and Benzonitriles under Catalyst‐Free Conditions.
Authors: Feng Jian‐Bo , Wu Xiao‐Feng
Published: November 2016

The method affords various substituted isoquinolines in different yields.
ChemInform Abstract: N,N‐Dimethylacetamide (DMA) as a Methylene Synthon for Regioselective Linkage of Imidazo[1,2‐a]pyridine.
Authors: Modi Anju , Ali Wajid , Patel Bhisma K.
Published: November 2016

DMA (II) serves as methylene source and solvent in the process which provides a series of heterocyclic dimers required in medicinal and material chemistry.
ChemInform Abstract: A Concise Synthesis of Quinolinium, and Biquinolinium Salts and Biquinolines from Benzylic Azides and Alkenes Promoted by Copper(II) Species.
Authors: Chen Wei‐Chen , Gandeepan Parthasarathy , Tsai Chia‐Hung , Luo Ching‐Zong , Rajamalli Pachaiyappan , Cheng Chien‐Hong
Published: November 2016

The reaction probably proceeds through a Lewis acidic CuII‐assisted rearrangement of benzylic azide to N‐methylaniline, followed by a [4+2] cycloaddition with alkene.
ChemInform Abstract: Oxidative Radical Addition—Cyclization of Sulfonyl Hydrazones with Simple Olefins by Binary Acid Catalysis.
Authors: Zhong Xingren , Lv Jian , Luo Sanzhong
Published: November 2016

The scalable title reaction offers access to tetrahydropyridazines from N‐tosylhydrazones and styrenes, including 1,1‐disubstituted derivatives, as well as alkyl alkenes and cyclopentadiene.
ChemInform Abstract: Synthesis of Substituted 4‐, 5‐, 6‐, and 7‐Azaindoles from Aminopyridines via a Cascade C—N Cross‐Coupling/Heck Reaction.
Authors: Pires Marina J. D. , Poeira Diogo L. , Purificacao Sara I. , Marques M. Manuel B.
Published: November 2016

The procedure represents the first approach to all four azaindole isomers via cascade C‐N cross‐coupling/Heck reaction.
ChemInform Abstract: A Choline Hydroxide Catalyzed Synthesis of 2,3‐Dihydroquinazolin‐4(1H)‐ones in an Aqueous Medium.
Authors: Borase Pravin N. , Thale Pranila B. , Shankarling G. S.
Published: November 2016

Cholin hydroxide is found to be a clean, recyclable (up to 6 times) and green catalyst for the synthesis of the title compounds from 2‐aminobenzonitriles and aldehydes.
ChemInform Abstract: Dihydrooxazine N‐Oxide Intermediates as Resting States in Organocatalytic Kinetic Resolution of Functionalized Nitroallylic Amines with Aldehydes.
Authors: Gurubrahamam Ramani , Chen Yan Ming , Huang Wan‐Yun , Chan Yu‐Te , Chang Hsiang‐Kai , Tsai Ming‐Kang , Chen Kwunmin
Published: November 2016

Further hydrolysis of the title intermediates provides tetrahydropyridines in high yields and with high diastereo‐ and enantioselectivities.
ChemInform Abstract: Copper‐Catalyzed Regio and Diastereoselective Three Component C—N, C—C and C—O Bond Forming Reaction: Oxidative sp3 C—H Functionalization.
Authors: Gupta Kankatala S. V. , Ramana Daggupati V. , Vinayak Botla , Sridhar Balasubramanian , Chandrasekharam Malapaka
Published: November 2016

21 Tetrahydroisoquinoline derivatives of type (IV) or (VII) are prepared by a one‐pot three‐component reaction comprising the formation of a C—N, a C—C and a C—O bond.
ChemInform Abstract: Sodium Chlorate as a Viable Substoichiometric Oxidant for Cobalt‐Catalyzed Oxidative Annulation of Aryl Sulfonamides with Alkynes.
Authors: Ran You , Yang Yudong , Zhang Luoqiang
Published: November 2016

For the first time, NaClO3 is demonstrated to be a versatile oxidant in the catalytic C—H activation of N‐(8‐quinolyl) substituted sulfonamides which react with alkynes to give sultams in good yields.
ChemInform Abstract: Site‐Selective Aliphatic C—H Silylation of 2‐Alkyloxazolines Catalyzed by Ruthenium Complexes.
Authors: Kon Kazumasa , Suzuki Hiroyuki , Takada Kosuke , Kohari Yoshihito , Namikoshi Takeshi , Watanabe Shinji , Murata Miki
Published: November 2016

Some heterocyclic substrates, substituted at the ortho‐position of a heteroatom with alkyl substituents bearing a site‐selective methyl group, are successfully silylated with reagent (II).
ChemInform Abstract: Natural‐Antioxidant‐Inspired Benzo[b]selenophenes: Synthesis, Redox Properties, and Antiproliferative Activity.
Authors: Paegle Edgars , Domracheva Ilona , Turovska Baiba , Petrova Marina , Kanepe‐Lapsa Iveta , Gulbe Anita , Liepinsh Edvards , Arsenyan Pavel
Published: November 2016

Cyclization of fluorinated arylalkynes (I) under selenobromination conditions affords the required precursors (II).
ChemInform Abstract: Practical Stannylation of Allyl Acetates Catalyzed by Nickel with Bu3SnOMe.
Authors: Komeyama Kimihiro , Itai Yuuhei , Takaki Ken
Published: November 2016

Different types of starting acetates are used in the process.
ChemInform Abstract: Stereoselective Koenigs—Knorr Glycosylation Catalyzed by Urea.
Authors: Sun Lifeng , Wu Xiaowei , Xiong De‐Cai , Ye Xin‐Shan
Published: November 2016

A stereoselective Koenigs—Knorr glycosylation reaction under the catalysis of urea is described.
ChemInform Abstract: Hyperhexanone A, a Crucial Intermediate from Bicyclo[3.3.1]‐ to Cyclohexanone Monocyclic‐Polycyclic Polyprenylated Acylphloroglucinols.
Authors: Zhu Hucheng , Chen Chunmei , Yang Jing , Li Dongyan , Zhang Jinwen , Guo Yi , Wang Jianping , Luo Zengwei , Xue Yongbo , Zhang Yonghui
Published: November 2016

Two novel polycyclic polyprenylated acylphloroglucinol (PPAP) derivatives Hyperhexanone A (I) and B (II) are isolated from Hypericum sampsonii.
ChemInform Abstract: Cold Sintering: A Paradigm Shift for Processing and Integration of Ceramics.
Authors: Guo Jing , Guo Hanzheng , Baker Amanda L. , Lanagan Michael T. , Kupp Elizabeth R. , Messing Gary L. , Randall Clive A.
Published: November 2016

A new sintering technique (cold sintering) for ceramics and ceramic‐based composites using water as a transient solvent to effect densification at temperatures between room temperature and 200 °C is described.
ChemInform Abstract: The Intercalation Chemistry of Layered Iron Chalcogenide Superconductors
Authors: Vivanco Hector K. , Rodriguez Efrain E.
Published: November 2016

Review: 158 refs.
ChemInform Abstract: Thioether Coordination Chemistry for Molecular Imaging of Copper in Biological Systems
Authors: Ramos‐Torres Karla M , Kolemen Safacan , Chang Christopher J.
Published: November 2016

Review: 115 refs.
ChemInform Abstract: Organophosphines in Organoplatinum Complexes: Structural Aspects of PtP2CX (X: SL, SeL, SiL, TeL) Derivatives
Authors: Melnik Milan , Mikus Peter
Published: November 2016

Review: 61 refs.
ChemInform Abstract: The Prowess of Photogenerated Amine Radical Cations in Cascade Reactions: From Carbocycles to Heterocycles
Authors: Morris Scott A. , Wang Jiang , Zheng Nan
Published: November 2016

Review: 59 refs.
ChemInform Abstract: The Literature of Heterocyclic Chemistry. Part 13. 2012—2013
Authors: Belen'kii Leonid I. , Evdokimenkova Yu B.
Published: November 2016

Review: 2107 refs.
ChemInform Abstract: Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis
Authors: Karkas Markus D. , Porco John A. , Stephenson Corey R. J.
Published: November 2016

Review: 540 refs.
ChemInform Abstract: Overcoming Synthetic Challenges in Target Synthesis Using SmI2: Recent Advances
Authors: Just‐Baringo Xavier , Yalavac Irem , Procter David
Published: November 2016

Review: 77 refs.
ChemInform Abstract: Supramolecular Photochemistry as a Potential Synthetic Tool: Photocycloaddition
Authors: Ramamurthy Vaidhyanathan , Sivaguru Jayaraman
Published: November 2016

Review: 546 refs.
ChemInform Abstract: Using Singlet Oxygen to Synthesize Natural Products and Drugs
Authors: Ghogare Ashwini A. , Greer Alexander
Published: November 2016

Review: 366 refs.
ChemInform Abstract: Catalytic Carbon—Carbon Sigma‐Bond Hydrogenolysis
Authors: To Ching Tat , Chan Kin Shing
Published: November 2016

Review: [28 refs.
ChemInform Abstract: Polystannanes: Processible Molecular Metals with Defined Chemical Structures
Authors: Caseri Walter
Published: November 2016

Review: 47 refs.
ChemInform Abstract: Preparation of Polyphosphazenes: A Tutorial Review
Authors: Rothemund Sandra , Teasdale Ian
Published: November 2016

Review: 50 refs.
ChemInform Abstract: Multifunctional Polymetallaynes: Properties, Functions and Applications
Authors: Ho Cheuk‐Lam , Yu Zhen‐Qiang , Wong Wai‐Yeung
Published: November 2016

Review: [structure‐property‐function relationships of the title metallopolymers and their emerging applications in electronic, optical and magnetic devices; 101 refs.
ChemInform Abstract: Metal‐Containing and Related Polymers for Biomedical Applications
Authors: Yan Yi , Zhang Jiuyang , Ren Lixia , Tang Chuanbing
Published: November 2016

Review: recent progress in the biomedical applications of metal‐containing polymers; 301 refs.
ChemInform Abstract: β‐Ionone and Its Analogs as Promising Anticancer Agents
Authors: Ansari Mahsa , Emami Saeed
Published: November 2016

Review: 102 refs.
ChemInform Abstract: Synthetic Strategy with Representation on Mechanistic Pathway for the Therapeutic Applications of Dihydroquinazolinones
Authors: Hemalatha K. , Madhumitha G.
Published: November 2016

Review: 114 refs.
ChemInform Abstract: Oxindole: A Chemical Prism Carrying Plethora of Therapeutic Benefits
Authors: Kaur Maninder , Singh Manjinder , Chadha Navriti , Silakari Om
Published: November 2016

Review: 149 refs.
ChemInform Abstract: Carbon Nano‐Onions: Large‐Scale Preparation, Functionalization and Their Application as Anode Material for Rechargeable Lithium ion Batteries
Authors: Zheng Yanbin , Zhu Pinwen
Published: November 2016

Review: 114 refs.
ChemInform Abstract: Corannulene Derivatives for Organic Electronics: From Molecular Engineering to Applications
Authors: Chen Rui , Lu Ru‐Qiang , Shi Pei‐Chen , Cao Xiao‐Yu
Published: November 2016

Review: 87 refs.
ChemInform Abstract: Crystallization‐Induced Phosphorescence of Pure Organic Luminogens
Authors: Wang Chun‐Rui , Gong Yong‐Yang , Yuan Wang‐Zhang , Zhang Yong‐Ming
Published: November 2016

Review: [30 refs.
ChemInform Abstract: New Applications of Poly(arylene Ether)s in Organic Light‐Emitting Diodes
Authors: Shao Shi‐Yang , Ding Jun‐Qiao , Wang Li‐Xiang
Published: November 2016

Review: 51 refs.
ChemInform Abstract: Triplet Fusion Delayed Fluorescence Materials for OLEDs
Authors: Luo Yan‐Ju , Lu Zhi‐Yun , Huang Yan
Published: November 2016

Review: [51 refs.
ChemInform Abstract: A Practical Guide to High‐Resolution X‐Ray Spectroscopic Measurements and Their Applications in Bioinorganic Chemistry
Authors: Kowalska Joanna K. , Lima Frederico A. , Pollock Christopher J. , Rees Julian A. , DeBeer Serena
Published: November 2016

Review: 91 refs.
ChemInform Abstract: Benzoic‐Imine‐Based Physiological‐pH‐Responsive Materials for Biomedical Applications
Authors: Qu Xiaozhong , Yang Zhenzhong
Published: November 2016

Review: 128 refs.
Needle tract seeding after percutaneous biopsy of sarcoma: Risk/benefit considerations
Authors: Berger‐Richardson David , Swallow Carol J.
Published: November 2016

To evaluate histologic subtype and grade, which in turn guide the decision making for multimodality therapy, the workup of suspected sarcoma requires more material than can be obtained from a fine‐needle aspiration. Either open or percutaneous core needle biopsy is indicated before a management decision is made. Percutaneous biopsy of a potentially malignant lesion is controversial, given the perceived potential for tumor seeding along the needle tract. However, the evidence that the latter is a significant risk is weak at best. To the authors’ knowledge, among cases of patients with extremity sarcoma who have undergone core needle biopsy, only a few cases of needle tract seeding have been reported to date. Although en bloc excision of the needle tract with the primary tumor is often performed, this practice is not associated with improved oncologic outcomes; the evidence for excision of the needle tract is poor. For patients with gastrointestinal stromal tumors, there is a theoretical risk of peritoneal dissemination after percutaneous biopsy, but to the authors’ knowledge this remains unproven. Although endoscopic ultrasound is the preferred route for biopsy among patients with gastrointestinal stromal tumors, percutaneous biopsy is indicated if endoscopic ultrasound is unsuitable or unavailable. In the setting of retroperitoneal sarcoma, a review of pooled data from 4 large tertiary care referral centers demonstrated a risk of needle tract seeding of 0.37%. The authors concluded that the benefits of pretreatment biopsy in patients with mesenchymal tumors outweigh the potential risks of needle tract seeding. Cancer 2017;123:560–567. © 2016 American Cancer Society.
Non–muscle‐invasive bladder cancer: Intravesical treatments beyond Bacille Calmette‐Guérin
Authors: Packiam Vignesh T. , Johnson Scott C. , Steinberg Gary D.
Published: November 2016

An unmet need exists for patients with high‐risk non–muscle‐invasive bladder cancer for whom bacille Calmette‐Guérin (BCG) has failed and who seek further bladder‐sparing approaches. This shortcoming poses difficult management dilemmas. This review explores previously investigated first‐line intravesical therapies and discusses emerging second‐line treatments for the heterogeneous group of patients for whom BCG has failed. The myriad of recently published and ongoing trials assessing novel salvage intravesical treatments offer promise to patients who both seek an effective cure and want to avoid radical surgery. However, these trials must carefully be contextualized by specific patient, tumor, and recurrence characteristics. As data continue to accumulate, there will potentially be a role for these agents as second‐line or even first‐line intravesical therapies. Cancer 2017;123:390–400. © 2016 American Cancer Society.
Modulation of the Polymerization Kinetics of α/β‐Tubulin by Osmolytes and Macromolecular Crowding
Authors: Schummel Paul Hendrik , Gao Mimi , Winter Roland
Published: November 2016

Tubulin is one of the main components of the cytoskeleton and can be found in nearly all eukaryotic cells. In this study, we explored the effects of kosmotropic and chaotropic osmolytes, such as trimethylamine‐N‐oxide (TMAO) and the metabolic waste product urea, as well as the crowding agents Ficoll and sucrose on the polymerization reaction of α/β‐tubulin. Time‐dependent turbidimetry and fluorescence anisotropy experiments were performed to explore the kinetics of the polymerization reaction. Under different solvent conditions, diverse changes in the lag time, the half‐life of the polymerization reaction, and the critical concentration of the polymerization reaction were observed. The apparent growth rate of the formation of microtubules was dramatically decreased in the presence of urea but significantly increased in the presence of TMAO. Measurements using mixtures of these two cosolvents showed that TMAO was able to counteract the deteriorating effect of urea on the polymerization reaction of tubulin. To create a more cell‐like environment, Ficoll was added as a macromolecular crowding agent. The presence of 10 wt % Ficoll increased the apparent growth rate by one order of magnitude. Our results clearly show that the polymerization of tubulin is very sensitive to the surrounding solvent.
Benzodifuran Derivatives as Potential Antiproliferative Agents: Possible Correlation between Their Bioactivity and Aggregation Properties
Authors: Musumeci Domenica , Roviello Giovanni N. , Rigione Giuseppina , Capasso Domenica , Di Gaetano Sonia , Riccardi Claudia , Roviello Valentina , Montesarchio Daniela
Published: November 2016

To further explore the properties and bioactivity of benzodifurans, three compounds in this class were synthesised and characterised using spectroscopic and spectrometric techniques, as well as SEM and thermogravimetric analysis. The synthesised compounds showed interesting antiproliferative activity on different human cancer cells (HeLa, Hep‐G2, WM266), whereas no relevant cytotoxic effect was observed on healthy control cells. To study the possible mechanism of action of the benzodifurans, their ability to bind various model DNA systems, their aggregation properties, and their ability to bind biologically relevant metal ions was evaluated. The molecules were found to form monodisperse nanoaggregates stable at physiological temperature, which are likely related to the observed bioactivity.
Lowstand wedges in carbonate platform slopes (Quaternary, Maldives, Indian Ocean)
Authors: Betzler Christian , Hübscher Christian , Lindhorst Sebastian , Lüdmann Thomas , Reijmer John J. G. , Braga Juan‐Carlos
Published: November 2016

Seismic, hydroacoustic and sedimentological data were used to analyse the response of atoll‐slope sedimentation in the Maldives to the late Quaternary sea‐level change. The slope deposits, as imaged in multichannel seismic profiles, are arranged into stacked aggrading to backstepping basinward thinning wedges. In a piston core recovered at the lower slope of one of the atolls, the sediment texture ranges from packstone to rudstone. Major components are blackened bioclasts, the large benthic foraminifers Operculina and Amphistegina, together with Halimeda debris and red algae. Radiocarbon dating at a core depth of 66 cm indicates that the wedge sedimentation stopped or was largely reduced after 16 ka BP. Therefore, the atoll‐slope deposits largely consist of sediment formed in situ and deposited during the last glacial lowstand in sea‐level. This is in apparent contradiction to the concept of highstand shedding of tropical carbonate platforms, which requires slope sedimentation during sea‐level highstands, when the platform is flooded. Rather than intrinsic factors, such as sediment bypass along the steep slope, the extrinsic process of current winnowing of the slope appears to be a major controlling factor in the production of this feature. This process may be relevant for other case studies of carbonate platforms, as currents may be accelerated around such edifices, leading to slope winnowing and sediment deposition in more current‐protected zones. The study results also have consequences for the interpretation of outcrop and seismic subsurface data of carbonate platform slope series, because such slope sediment wedges are not necessarily formed during sea‐level highstands, but can consist of lowstand wedges only.
Running during adolescence rescues a maternal separation‐induced memory impairment in female mice: Potential role of differential exon‐specific BDNF expression
Authors: Wearick‐Silva Luis Eduardo , Marshall Paul , Viola Thiago Wendt , Centeno‐Silva Anderson , de Azeredo Lucas Araújo , Orso Rodrigo , Li Xiang , Donadio Márcio V. , Bredy Timothy W. , Grassi‐Oliveira Rodrigo
Published: November 2016

Exposure to early life stress has been associated with memory impairments related to changes in brain‐derived neurotrophic factor (BDNF) signaling. However, the potential impact of physical exercise to reverse these effects of maternal separation has been under investigated. Mice were subjected to maternal separation during the first 2 weeks of life and then exposed to a 3‐week running protocol during adolescence. The spontaneous object recognition task was performed during adolescence followed by analysis of hippocampal expression of exons I, IV, and IX of the BDNF gene. As expected, maternal separation impaired recognition memory and this effect was reversed by exercise. In addition, running increased BDNF exon I expression, but decreased expression of BDNF exon IV in all groups, while exon IX expression increased only in MS animals exposed to exercise. Our data suggest that memory deficits can be attenuated by exercise and specific transcripts of the BDNF gene are dynamically regulated following both MS and exercise.
Synthesis of Quinazolinones, Imidazo[1,2‐c]quinazolines and Imidazo[4,5‐c]quinolines through Tandem Reductive Amination of Aryl Halides and Oxidative Amination of C(sp3)–H Bonds
Authors: Nandwana Nitesh Kumar , Dhiman Shiv , Saini Hitesh Kumar , Kumar Indresh , Kumar Anil
Published: November 2016

A tandem multicomponent approach has been described for the synthesis of quinazolinones, imidazo[1,2‐c]quinazolines and imidazo[4,5‐c]quinolines. The reaction involves a copper‐catalyzed reductive amination through azidation followed by reduction and oxidative amination of C(sp3)–H bonds of N,N‐dimethylacetamide in the presence of TBHP (tert‐butylhydroperoxide) as oxidant. The method uses the easily available sodium azide as a nitrogen source and DMA (N,N‐dimethylacetamide) as a one‐carbon source for the synthesis of these N‐fused heterocycles in good to excellent yields. The reaction can also be used for gram‐scale synthesis.
Screen‐printed Tattoo Sensor towards the Non‐invasive Assessment of the Skin Barrier
Authors: De Guzman Keana , Morrin Aoife
Published: November 2016

The development and characterisation of a screen‐printed tattoo sensor for the non‐invasive assessment of the skin barrier is presented. A screen‐printed silver tattoo sensor comprising two concentric circle electrodes was fabricated and applied and characterised initially on a soft tissue mimic. It was shown that the tattoo was capable of tracking changes in water content in the soft tissue mimic using impedance spectroscopy. The tattoo sensors were then applied to porcine and human skins and impedance spectroscopy was used to interrogate the skin at the outer stratum corneum (SC). The SC is a layer of great interest from a dermatological point of view since it plays a critical role in the barrier function of the skin by protecting underlying tissue from infection, dehydration, chemical irritants and mechanical stress. Hydration changes were tracked in the skin using the impedance approach and validated against a tissue dielectric constant (TDC) measurement taken with the MoistureMeterD (MMD, Delfin Technologies). The impedimetric results obtained using the tattoo sensor were modelled into proposed circuit models representative of the systems measured. From this study, the potential of using wearable tattoo electrodes coupled with impedance spectroscopy as a transduction technique, to investigate skin barrier status offers considerable promise towards the monitoring and self‐management of skin health.
Tuning the Composition of PdCuNi Hollow Nanospheres for Low Cost and Efficient Catalyst Towards Glycol Electrooxidation
Authors: Hong Wei , Shang Changshuai , Wang Jin , Wang Erkang
Published: November 2016

In this research, we reported an effective approach to prepare low cost and efficient electrocatalyst for the glycol electrooxidation. The synthetic process involves the replacement reactions between CuCl2/H2PdCl4 and Ni nanospheres template. Through controlling the precursor ratio, the Pd/Cu/Ni ratio of the final trimetallic products can be tuned. The prepared electrocatalysts present a monodispersed nanospheres structure with a hollow cavity. The prepared Pd41Cu27Ni9 shows the best catalytic activity (0.021 A cm−2 at 0.9 V vs. RHE) for glycol electrooxidation, which is much higher than that of the commercial Pd/C (0.0014 A cm−2 at 0.9 V vs. RHE).
Effect of purified fractions from cell culture supernate of high‐density pre‐B acute lymphoblastic leukemia cells (ALL3) on the growth of ALL3 cells at low density
Authors: Patel Sapan J. , Darie Costel C. , Clarkson Bayard D.
Published: November 2016

The mechanisms underlying the aberrant growth and interactions between cells are not understood very well. The pre‐B acute lymphoblastic leukemia cells directly obtained from an adult patient grow very poorly or do not grow at all at low density (LD), but grow better at high starting cell density (HD). We found that the LD ALL3 cells can be stimulated to grow in the presence of diffusible, soluble factors secreted by ALL3 cells themselves growing at high starting cell density. We then developed a biochemical purification procedure that allowed us to purify the factor(s) with stimulatory activity and analyzed them by nanoliquid chromatography‐tandem mass spectrometry (nanoLC‐MS/MS). Using nanoLC‐MS/MS we have identified several proteins which were further processed using various bioinformatics tools. This resulted in eight protein candidates which might be responsible for the growth activity on non‐growing LD ALL3 cells and their involvement in the stimulatory activity are discussed.
Additive toxicity of zinc and arsenate on barley (Hordeum vulgare) root elongation
Authors: Guzmán-Rangel Georgina , Versieren Liske , Qiu Hao , Smolders Erik
Published: November 2016

Zinc (Zn) and arsenic (As) are typically present as mixed contaminants in mining-impacted areas; however, their joined effects have rarely been evaluated. The present study was set up to test whether the Zn2+ and H2AsO4– (hereafter, As) mixture toxicity to plants is additive or whether interactions occur. Barley (Hordeum vulgare) root elongation was measured in resin buffered nutrient solutions. The design included ranges of single-element concentrations and combinations at 3 different Ca2+ concentrations (0.5 mM, 2.2 mM, and 15.0 mM) to vary the relative toxicity of Zn2+. Increasing Ca concentrations decreased Zn toxicity, whereas As toxicity was unaffected by Ca. Root elongation was generally more affected in Zn–As mixtures than in corresponding single-element treatments. This is merely a joint additive effect, as 96% of the root elongation data were within a factor of 1.2 from predictions using the independent action (IA) or concentration addition (CA) model. The CA and IA predictions were similar, and data did not allow identification of equal or dissimilar modes of action. Small but significant Zn–As antagonisms were only found at high effects (>50% inhibition). The present study suggests that mixture effects of Zn and As are environmentally relevant and that current risk assessment underestimates toxicity in multielement-contaminated environments. The CA model can be used as a conservative model for risk assessment; however, for soil-grown plants, soil-exposed studies are needed. Environ Toxicol Chem 2017;36:1556–1562. © 2016 SETAC