bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation of Endogenous and Exogenous Mesenchymal Progenitor Cells for Skeletal Tissue Regeneration and Repair
Authors: Desai Salomi , Jayasuriya Chathuraka T.
Published: August 2020

Harnessing adult mesenchymal stem/progenitor cells to stimulate skeletal tissue repair is a strategy that is being actively investigated. While scientists continue to develop creative and thoughtful ways to utilize these cells for tissue repair, the vast majority of these methodologies can ultimately be categorized into two main approaches: (1) Facilitating the recruitment of endogenous host cells to the injury site; and (2) physically administering into the injury site cells themselves, exogenously, either by autologous or allogeneic implantation. The aim of this paper is to comprehensively review recent key literature on the use of these two approaches in stimulating healing and repair of different skeletal tissues. As expected, each of the two strategies have their own advantages and limitations (which we describe), especially when considering the diverse microenvironments of different skeletal tissues like bone, tendon/ligament, and cartilage/fibrocartilage. This paper also discusses stem/progenitor cells commonly used for repairing different skeletal tissues, and it lists ongoing clinical trials that have risen from the implementation of these cells and strategies. Lastly, we discuss our own thoughts on where the field is headed in the near future.
Salvia Spp. Essential Oils against the Arboviruses Vector Aedes albopictus (Diptera: Culicidae): Bioactivity, Composition, and Sensorial Profile—Stage 1
Authors: Najar Basma , Pistelli Luisa , Venturi Francesca , Ferroni Giuseppe , Giovanelli Silvia , Cervelli Claudio , Bedini Stefano , Conti Barbara
Published: August 2020

Mosquito-borne arboviruses diseases cause a substantial public health burden within their expanding range. To date, their control relies on synthetic insecticides and repellents aimed to control the competent mosquito vectors. However, their use is hampered by their high economic, environmental, and human health impacts. Natural products may represent a valid eco-friendly alternative to chemical pesticides to control mosquitoes, and mosquito-borne parasitic diseases. The aim of this work was to combine the chemical and sensorial profiles with the bioactivity data of Salvia spp. essential oils (EOs) to select the most suitable EO to be used as a repellent and insecticide against the invasive mosquito Aedes albopictus (Diptera: Culicidae), vector of pathogens and parasites, and to describe the EOs smell profile. To do this, the EOs of four Salvia species, namely S. dolomitica, S. dorisiana, S. sclarea, and S. somalensis were extracted, chemically analyzed and tested for their bioactivity as larvicides and repellents against Ae. albopictus. Then, the smell profiles of the EOs were described by a panel of assessors. The LC50 of the EOs ranged from 71.08 to 559.77 μL L−1 for S. dorisiana and S. sclarea, respectively. S. sclarea EO showed the highest repellence among the tested EOs against Ae. albopictus females (RD95 = 12.65 nL cm−2), while the most long-lasting, at the dose of 20 nL cm−2, was S. dorisiana (Complete Protection Time = 43.28 ± 3.43 min). S. sclarea EO showed the best smell profile, while S. dolomitica EO the worst one with a high number of off-flavors. Overall, all the EOs, with the exception of the S. dolomitica one, were indicated as suitable for “environmental protection”, while S. dorisiana and S. sclarea were indicated as suitable also for “Body care”.
Mathematical Profile Test: A Preliminary Evaluation of an Online Assessment for Mathematics Skills of Children in Grades 1–6
Authors: Karagiannakis Giannis , Noël Marie-Pascale
Published: August 2020

The domain of numerical cognition still lacks an assessment tool that is theoretically driven and that covers a wide range of key numerical processes with the aim of identifying the learning profiles of children with difficulties in mathematics (MD) or dyscalculia. This paper is the first presentation of an online collectively administered tool developed to meet these goals. The Mathematical Profile Test (MathPro Test) includes 18 subtests that assess numerical skills related to the core number domain or to the visual-spatial, memory or reasoning domains. The specific aim of this paper is to present the preliminary evaluation both of the sensitivity and the psychometric characteristics of the individual measures of the MathPro Test, which was administered to 622 primary school children (grades 1–6) in Belgium. Performance on the subtests increased across all grades and varied along the level of difficulty of the items, supporting the sensitivity of the test. The MathPro Test also showed satisfactory internal consistency and significant and stable correlation with a standardized test in mathematics across all grades. In particular, the achievement in mathematics was strongly associated with the performance on the subtests assessing the reasoning and the visuospatial domains throughout all school grades, whereas associations with the core number and memory tasks were found mainly in the younger children. MD children performed significantly lower than their peers; these differences in performance on the MathPro subtests also varied according to the school grades, informing us about the developmental changes of the weaknesses of children with MD. These results suggest that the MathPro Test is a very promising tool for conducting large scale research and for clinicians to sketch out the mathematical profile of children with MD or dyscalculia.
EMT-Inducing Transcription Factors, Drivers of Melanoma Phenotype Switching, and Resistance to Treatment
Authors: Tang Yaqi , Durand Simon , Dalle Stéphane , Caramel Julie
Published: August 2020

Transcription factors, extensively described for their role in epithelial–mesenchymal transition (EMT-TFs) in epithelial cells, also display essential functions in the melanocyte lineage. Recent evidence has shown specific expression patterns and functions of these EMT-TFs in neural crest-derived melanoma compared to carcinoma. Herein, we present an update of the specific roles of EMT-TFs in melanocyte differentiation and melanoma progression. As major regulators of phenotype switching between differentiated/proliferative and neural crest stem cell-like/invasive states, these factors appear as major drivers of intra-tumor heterogeneity and resistance to treatment in melanoma, which opens new avenues in terms of therapeutic targeting.
Multiple Myeloma as a Bone Disease? The Tissue Disruption-Induced Cell Stochasticity (TiDiS) Theory
Authors: Capp Jean-Pascal , Bataille Régis
Published: August 2020

The standard model of multiple myeloma (MM) relies on genetic instability in the normal counterparts of MM cells. MM-induced lytic bone lesions are considered as end organ damages. However, bone is a tissue of significance in MM and bone changes could be at the origin/facilitate the emergence of MM. We propose the tissue disruption-induced cell stochasticity (TiDiS) theory for MM oncogenesis that integrates disruption of the microenvironment, differentiation, and genetic alterations. It starts with the observation that the bone marrow endosteal niche controls differentiation. As decrease in cellular stochasticity occurs thanks to cellular interactions in differentiating cells, the initiating role of bone disruption would be in the increase of cellular stochasticity. Thus, in the context of polyclonal activation of B cells, memory B cells and plasmablasts would compete for localizing in endosteal niches with the risk that some cells cannot fully differentiate if they cannot reside in the niche because of a disrupted microenvironment. Therefore, they would remain in an unstable state with residual proliferation, with the risk that subclones may transform into malignant cells. Finally, diagnostic and therapeutic perspectives are provided.
The Pathologic and Molecular Landscape of Esophageal Squamous Cell Carcinogenesis
Authors: Businello Gianluca , Parente Paola , Mastracci Luca , Pennelli Gianmaria , Traverso Giulia , Milione Massimo , Bellan Elena , Michelotto Mauro , Kotsafti Andromachi , Grillo Federica , Fassan Matteo
Published: August 2020

Esophageal squamous cell carcinoma represents the most common histotype of epithelial neoplasm occurring within esophageal mucosa worldwide. Despite the comprehensive molecular characterization of this entity, to date no significant targeted therapy has been introduced into clinical practice. In this review, we describe the molecular landscape of esophageal squamous cell carcinoma based on the most recent literature. Moreover, we focus on other rare variants and on the relationship with head and neck squamous cell carcinomas.
Laryngeal Mid-Cord Erythroleukoplakias: How to Modulate the Transoral CO2 Laser Excisional Biopsy
Authors: Mora Francesco , Carta Filippo , Missale Francesco , Laborai Andrea , Parrinello Giampiero , Piazza Cesare , Puxeddu Roberto , Peretti Giorgio
Published: August 2020

Background: The endoscopic appearance of glottic erythroleukoplakias is non-predictive of their histopathology, potentially ranging from keratosis to invasive squamous cell carcinoma (SCC). The aim of this study was to assess a comprehensive workup for the one-step diagnosis and treatment of mid-cord erythroleukoplakias, using CO2 laser excisional biopsy. Methods: We evaluated 147 untreated patients affected by 155 mid-cord erythroleukoplakias submitted to excisional biopsy by subepithelial (Type I) or subligamental cordectomy (Type II), across two academic institutions. Patients were evaluated by preoperative videolaryngostroboscopy, pre- and intraoperative videoendoscopy with biologic endoscopy (narrow band imaging, NBI, or the Storz professional image enhancement system, SPIES), either with or without intraoperative saline infusion into the Reinke’s space. Adequacy of treatment was the primary outcome. Results: The histopathologic diagnosis was keratosis in 26 (17%) cases, squamous intraepithelial neoplasia (SIN1-2) in 47 (30%), carcinoma in situ in 21 (14%), and SCC in 61 (39%) patients. The adequacy of treatment across the entire cohort was 89%. The intraoperative saline infusion procedure, facing not clearly suspicious lesions, raised the adequacy of treatment from 60% to 90% (p = 0.006). Conclusions: Excisional biopsy by Type I–II cordectomies, after a comprehensive diagnostic workup, should be accepted as an adequate and cost-effective treatment of unilateral mid-cord glottic erythroleukoplakias.
Contrast-Enhanced Ultrasound (CEUS) for Follow-Up of Bosniak 2F Complex Renal Cystic Lesions—A 12-Year Retrospective Study in a Specialized European Center
Authors: Rübenthaler Johannes , Čečatka Saša , Froelich Matthias Frank , Stechele Matthias , Marschner Constantin , Sabel Bastian Oliver , Bogner Florian , Schnitzer Moritz Ludwig , Overhoff Daniel , Große Hokamp Nils , Staehler Michael , Schwarze Vincent , Clevert Dirk-André
Published: August 2020

Bosniak 2F renal cystic lesions feature morphologic characteristics between Bosniak I and III categories, the majority of which remain benign. However, a minor part of Bosniak 2F lesions may progress to malignancy. The purpose of this study was to assess Bosniak 2F cystic lesions during follow-up examinations by CEUS. One-hundred-and-twelve out of 364 patients with Bosniak 2F lesions underwent follow-up CEUS examinations between February 2008 and February 2020. Twelve out of 364 patients underwent renal surgery without follow-up CEUS. The progression rate of Bosniak 2F renal lesions detected by CEUS accounted for 7.1% (8/112 patients) after a mean of 12.9 months. The first follow-up CEUS revealed 75% of progressions (6/8), the remaining 25% (2/8) of progressions were detected during second follow-up CEUS. Underlying clear-cell renal cell carcinoma was histopathologically validated in 5/8 progressive complex cystic renal lesions. Stable sonomorphologic features were observed in 92.1% (104/112 patients). CEUS depicts a promising diagnostic imaging modality in the diagnostic work-up and follow-up of complex renal cystic lesions at higher spatial and temporal resolutions than CT or MRI. Its excellent safety profile, its easy and repeatable accessibility, and low financial costs render CEUS an attractive and powerful alternative imaging tool for monitoring complex renal cystic lesions.
Formic Acid as a Hydrogen Source for the Additive-Free Reduction of Aromatic Carbonyl and Nitrile Compounds at Reusable Supported Pd Catalysts
Authors: Tomar Pooja , Nozoe Yuou , Ozawa Naoto , Nishimura Shun , Ebitani Kohki
Published: August 2020

Formic acid can be used as a hydrogen source for the hydrogenations of various aromatic carbonyl and nitrile compounds into their corresponding alcohols and amines using reusable heterogeneous Pd/carbon and Pd/Al2O3 catalysts, respectively, under additive-free and mild reaction conditions.
Visible Light Electromagnetic Interaction of PM567 Chiral Dye for Asymmetric Photocatalysis, a First-Principles Investigation
Authors: Dai Yujie , Lu Chen , Liang Lin , Feng Naixing , Wang Jingang
Published: August 2020

In asymmetric photocatalytic reactions, it is necessary to study the mechanism of the asymmetric electromagnetic interaction between molecules and light. In this work, we theoretically studied the electromagnetic interactions between the light-induced charge transfer reaction and the chiral reaction of PM567 dye. We found that the chiral responses of molecules in different wavelength ranges were partially due to pyrromethene and binaphthalene. Therefore, the catalytic sites with different chirality also corresponds to the two-part groups. Through quantitative analysis, we found the entire analysis process to be complete and self-consistent.
Molecular Imprinted Based Quartz Crystal Microbalance Sensors for Bacteria and Spores
Authors: Latif Usman , Can Serpil , Sussitz Hermann , Dickert Franz
Published: August 2020

A molecular imprinting strategy was combined with mass-sensitive transducers to generate robust and reliable biomimetic sensor systems for the detection of bioparticles. The patterning of polymers with bioanalytes enabled us to detect Escherichia coli (E. coli) bacteria with quartz crystal microbalance (QCM). The QCM sensor results were compared with direct Atomic Force Microscopy (AFM) measurements—bacteria cells adhering to the sensor coatings were counted. The recognition sites generated by Bacillus subtilis (B. subtilis) spores could successfully and reversibly recognize the template analyte and ensured rapid sensing. Cross sensitive measurements clearly showed the advantage of the molecular imprinting strategy, by which spores of Bacillus species (subtilis and thuringiensis) could easily be differentiated and selectively detected. The growth of B. subtilis from its spores was observed at 42 °C in appropriate nutrient solution of glucose and ammonium sulfate over a period of 15 h. Moreover, the growth of B. subtilis bacteria from its respective spores was studied by increasing the glucose concentration until saturation effect of the sensor. The polymeric sensor coatings were patterned to fix the B. subtilis in order to investigate osmotic effects according to a frequency response of 400 Hz by altering the ionic strength of 0.1 M.
Advances of Sensitive Infrared Detectors with HgTe Colloidal Quantum Dots
Authors: Zhang Shuo , Hu Yao , Hao Qun
Published: August 2020

The application of infrared detectors based on epitaxially grown semiconductors such as HgCdTe, InSb and InGaAs is limited by their high cost and difficulty in raising operating temperature. The development of infrared detectors depends on cheaper materials with high carrier mobility, tunable spectral response and compatibility with large-scale semiconductor processes. In recent years, the appearance of mercury telluride colloidal quantum dots (HgTe CQDs) provided a new choice for infrared detection and had attracted wide attention due to their excellent optical properties, solubility processability, mechanical flexibility and size-tunable absorption features. In this review, we summarized the recent progress of HgTe CQDs based infrared detectors, including synthesis, device physics, photodetection mechanism, multi-spectral imaging and focal plane array (FPA).
Hearing Loss in Mucopolysaccharidoses: Current Knowledge and Future Directions
Authors: Wolfberg Jeremy , Chintalapati Keerthana , Tomatsu Shunji , Nagao Kyoko
Published: August 2020

Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders caused by a deficiency of one of the enzymes involved in the degradation of glycosaminoglycans. Hearing loss is a common clinical presentation in MPS. This paper reviews the literature on hearing loss for each of the seven recognized subtypes of MPS. Hearing loss was found to be common in MPS I, II, III, IVA, VI, and VII, and absent from MPS IVB and MPS IX. MPS VI presents primarily with conductive hearing loss, while the other subtypes (MPS I, MPS II, MPS III, MPS IVA, and MPS VII) can present with any type of hearing loss (conductive, sensorineural, or mixed hearing loss). The sensorineural component develops as the disease progresses, but there is no consensus on the etiology of the sensorineural component. Enzyme replacement therapy (ERT) is the most common therapy utilized for MPS, but the effects of ERT on hearing function have been inconclusive. This review highlights a need for more comprehensive and multidisciplinary research on hearing function that includes behavioral testing, objective testing, and temporal bone imaging. This information would allow for better understanding of the progression and etiology of hearing loss. Owing to the prevalence of hearing loss in MPS, early diagnosis of hearing loss and annual comprehensive audiological evaluations are recommended.
Skyrmions and Spin Waves in Magneto–Ferroelectric Superlattices
Authors: Sharafullin Ildus F. , Diep Hung T.
Published: August 2020

We present in this paper the effects of Dzyaloshinskii–Moriya (DM) magneto–electric coupling between ferroelectric and magnetic interface atomic layers in a superlattice formed by alternate magnetic and ferroelectric films. We consider two cases: magnetic and ferroelectric films have the simple cubic lattice and the triangular lattice. In the two cases, magnetic films have Heisenberg spins interacting with each other via an exchange J and a DM interaction with the ferroelectric interface. The electrical polarizations of ±1 are assumed for the ferroelectric films. We determine the ground-state (GS) spin configuration in the magnetic film and study the phase transition in each case. In the simple cubic lattice case, in zero field, the GS is periodically non collinear (helical structure) and in an applied field H perpendicular to the layers, it shows the existence of skyrmions at the interface. Using the Green’s function method we study the spin waves (SW) excited in a monolayer and also in a bilayer sandwiched between ferroelectric films, in zero field. We show that the DM interaction strongly affects the long-wave length SW mode. We calculate also the magnetization at low temperatures. We use next Monte Carlo simulations to calculate various physical quantities at finite temperatures such as the critical temperature, the layer magnetization and the layer polarization, as functions of the magneto–electric DM coupling and the applied magnetic field. Phase transition to the disordered phase is studied. In the case of the triangular lattice, we show the formation of skyrmions even in zero field and a skyrmion crystal in an applied field when the interface coupling between the ferroelectric film and the ferromagnetic film is rather strong. The skyrmion crystal is stable in a large region of the external magnetic field. The phase transition is studied.
A Nonlinear Autoregressive Distributed Lag (NARDL) Analysis of West Texas Intermediate Oil Prices and the DOW JONES Index
Authors: Allen David E. , McAleer Michael
Published: August 2020

The paper features an examination of the link between the behaviour of oil prices and DowJones Index in a nonlinear autoregressive distributed lag nonlinear autoregressive distributed lag (NARDL) framework. The attraction of NARDL is that it represents the simplest method available of modelling combined short- and long-run asymmetries. The bounds testing framework adopted means that it can be applied to stationary and non-stationary time series vectors, or combinations of both. The data comprise a monthly West Texas Intermediate (WTI) crude oil series from Federal Reserve Bank of St Louis (FRED), commencing in January 2000 and terminating in February 2019, and a corresponding monthly DOW JONES index adjusted-price series obtained from Yahoo Finance. Both series are adjusted for monthly USA CPI values to create real series. The results of the analysis suggest that movements in the lagged real levels of monthly WTI crude oil prices have very significant effects on the behaviour of the DOW JONES Index. They also suggest that negative movements have larger impacts than positive movements in WTI prices, and that long-term multiplier effects take about 9 to 12 months to take effect.
Converting a Water Pressurized Network in a Small Town into a Solar Power Water System
Authors: Pardo Miguel Ángel , Fernández Héctor , Jodar-Abellan Antonio
Published: August 2020

The efficient management of water and energy is one challenge for managers of water pressurized systems. In a scheme with high pressure on the environment, solar power appears as an opportunity for nonrenewable energy expenditure reduction and emissions elimination. In Spain, new legislation that eliminates old taxes associated with solar energy production, a drop in the cost of solar photovoltaic modules, and higher values of irradiance has converted solar powered water systems into one of the trendiest topics in the water industry. One alternative to store energy (compulsory in standalone photovoltaic systems) when managing pressurized urban water networks is the use of head tanks (tanks accumulate water during the day and release it at night). This work intends to compare the pressurized network running as a standalone system and a hybrid solution that incorporates solar energy supply and electricity grids. The indicator used for finding the best choice is the net present value for the solar power water system lifespan. This study analyzed the possibility of transferring the energy surplus obtained at midday to the electricity grid, a circumstance introduced in the Spanish legislation since April 2019. We developed a real case study in a small town in the Alicante Province, whose findings provide planning policymakers with very useful information in this case and similar case studies
Carbon Dioxide Mixtures as Working Fluid for High-Temperature Heat Recovery: A Thermodynamic Comparison with Transcritical Organic Rankine Cycles
Authors: Ayub Abubakr , Invernizzi Costante M. , Di Marcoberardino Gioele , Iora Paolo , Manzolini Giampaolo
Published: August 2020

This study aims to provide a thermodynamic comparison between supercritical CO2 cycles and ORC cycles utilizing flue gases as waste heat source. Moreover, the possibility of using CO2 mixtures as working fluids in transcritical cycles to enhance the performance of the thermodynamic cycle is explored. ORCs operating with pure working fluids show higher cyclic thermal and total efficiencies compared to supercritical CO2 cycles; thus, they represent a better option for high-temperature waste heat recovery provided that the thermal stability at a higher temperature has been assessed. Based on the improved global thermodynamic performance and good thermal stability of R134a, CO2-R134a is investigated as an illustrative, promising working fluid mixture for transcritical power cycles. The results show that a total efficiency of 0.1476 is obtained for the CO2-R134a mixture (0.3 mole fraction of R134a) at a maximum cycle pressure of 200 bars, which is 15.86% higher than the supercritical carbon dioxide cycle efficiency of 0.1274, obtained at the comparatively high maximum pressure of 300 bars. Steam cycles, owing to their larger number of required turbine stages and lower power output, did not prove to be a suitable option in this application.
Vectorized Mathematical Model of a Slip-Ring Induction Motor
Authors: Wcislik Miroslaw , Suchenia Karol , Cyganik Andrzej
Published: August 2020

The paper deals with the modeling of a slip-ring induction motor. Induction motors are very often used in industry and their suitable model is needed to reduce control and operating costs. The identification process of self and mutual inductances of the stator and rotor, and mutual inductances between them in the function of the rotor rotation angle is presented. The dependence of each inductance on the rotor rotation angle is determined experimentally. The inductance matrix is then formulated. Taking the magnetic energy of the inductances and kinetic energy of the rotor into account, the Lagrange function is defined. Next, the motor motion equations are obtained. After making some algebraic transformations and using the dimensionless variables, the motion equations of electric circuits and of the mechanical equation are written separately in the forms facilitating their solution. The solution was obtained using the Simulink model for the stator and rotor currents in the form of vectors. The simulation was controlled by MATLAB script. The results of the simulation are presented in the form of basic variables time courses and compared with some values calculated with the use Steinmetz model of induction motor. The work is followed by two appendices, which contain procedures for determining the inverted inductance matrix.
New Multifunctional Isolated Microinverter with Integrated Energy Storage System for PV Applications
Authors: Barros Luis A. M. , Tanta Mohamed , Sousa Tiago J. C. , Afonso Joao L. , Pinto J. G.
Published: August 2020

This paper proposes a novel multifunctional isolated microinverter which is able to extract the maximum available power from a solar photovoltaic module and inject it into the power grid, while simultaneously charging a battery energy storage system (BESS). The proposed microinverter integrates a novel DC–DC power converter and a conventional DC–AC power converter. The DC–DC power converter is able to send electrical energy to the secondary side of a high-frequency transformer and to the BESS, using only two power switches. Throughout this paper, the converter topology, the operation modes, the control algorithms, and the development of a laboratory prototype of the proposed microinverter are described in detail. Moreover, simulation and experimental results are presented to demonstrate the feasibility of the proposed solution.
Examining the Impact of Daylighting and the Corresponding Lighting Controls to the Users of Office Buildings
Authors: Doulos Lambros T. , Tsangrassoulis Aris , Madias Evangelos-Nikolaos , Niavis Spyros , Kontadakis Antonios , Kontaxis Panagiotis A. , Kontargyri Vassiliki T. , Skalkou Katerina , Topalis Frangiskos , Manolis Evangelos , Sinou Maro , Zerefos Stelios
Published: August 2020

Daylight utilization significantly contributes to energy savings in office buildings. However, daylight integration requires careful design so as to include variations in daylight availability and maintain a balance between factors such as lighting quality and heat gain or loss. Designers with proper planning can not only improve the visual environment and create higher-quality spaces, but simultaneously minimize energy costs for buildings. The utilization of photosensors can exploit the benefits of daylighting by dimming the lighting system, so that no excessive luminous flux is produced, thus leading to energy savings as well as visual contentment. However, the human factor is crucial for the proper function of a lighting control system. Without its acceptance from the users, energy savings can be minimized or even negligible. The objective of this paper is to present a post-occupancy evaluation regarding occupant satisfaction and acceptance in relation to daylighting in offices equipped with automated daylight controls. In addition, the response of the users was compared with lighting measurements that were performed during the post-occupancy evaluation. Three case studies of office buildings with installed daylight-harvesting systems were examined. The age of the occupants was a crucial factor concerning their satisfaction in relation to the lighting levels. Aged users were more comfortable with lighting levels over 500lx, while young users were satisfied with 300lx. The impact of different control algorithms was outlined, with the integral reset algorithm performing poorly. The acceptance of the users for the closed loop systems maintained the expected energy savings of the daylight harvesting technique. Most of the occupants preferred to use daylight as a light source combined with artificial light but having the control to either override or switch it on and off at will. The results shown that a post-occupancy survey along with lighting measurements are significant for making an office environment a humancentric one.
Aerodynamic Drag Analysis of Autonomous Electric Vehicle Platoons
Authors: Kaluva Sai Teja , Pathak Aditya , Ongel Aybike
Published: August 2020

Vehicle platooning has been proposed as one of the potential technologies for intelligent transport systems to improve transportation and energy efficiency in urban cities. Despite extensive studies conducted on the platooning of heavy-duty trucks, literature on the analysis of urban vehicle platoons has been limited. To analyse the impact of platooning in urban environments, this paper studies the influence of intervehicle distance, platoon size and vehicle speed on the drag coefficient of the vehicles in a platoon using computational fluid dynamics (CFD). Two vehicle models—a minibus and a passenger car—are analysed to characterise the drag coefficients of the respective platoons. An analysis of energy consumption is conducted to evaluate the energy savings with platooning using a longitudinal dynamics simulation. The results showed a reduction in the average drag coefficient of the platoon of up to 24% at an intervehicle distance of 1 m depending on the number of vehicles in the platoon. With a larger intervehicle distance of 4 m, the reduction in the drag coefficient decreased to 4% of the drag coefficient of the isolated vehicle. Subsequently, energy savings with platooning were calculated to be up to 10% depending on the driving cycle, intervehicle distance and platoon size.
Combined Diagnostic Analysis of Dynamic Combustion Characteristics in a Scramjet Engine
Authors: Jeong Seung-Min , Choi Jeong-Yeol
Published: August 2020

In this work, the dynamic combustion characteristics in a scramjet engine were investigated using three diagnostic data analysis methods: DMD (Dynamic Mode Decomposition), STFT (Short-Time Fourier Transform), and CEMA (Chemical Explosive Mode Analysis). The data for the analyses were obtained through a 2D numerical experiment using a DDES (Delayed Detached Eddy Simulation) turbulence model, the UCSD (University of California at San Diego) hydrogen/oxygen chemical reaction mechanism, and high-resolution schemes. The STFT was able to detect that oscillations above 50 kHz identified as dominant in FFT results were not the dominant frequencies in a channel-type combustor. In the analysis using DMD, it was confirmed that the critical point that induced a complete change of mixing characteristics existed between an injection pressure of 0.75 MPa and 1.0 MPa. A combined diagnostic analysis that included a CEMA was performed to investigate the dynamic combustion characteristics. The differences in the reaction steps forming the flame structure under each combustor condition were identified, and, through this, it was confirmed that the pressure distribution upstream of the combustor dominated the dynamic combustion characteristics of this scramjet engine. From these processes, it was confirmed that the combined analysis method used in this paper is an effective approach to diagnose the combustion characteristics of a supersonic combustor.
IoT-Based Smart Plug for Residential Energy Conservation: An Empirical Study Based on 15 Months’ Monitoring
Authors: Oh Jooseok
Published: August 2020

The study examines the implications of educating prosumers regarding Internet of Things (IoT) use and monitoring to reduce power consumption in the home and encourage energy conservation, sustainable living, and behavior change. Over 15 months, 125 households and household owners received training regarding IoT plug equipment, usage monitoring, and energy reduction. A face to face survey was then conducted regarding power consumption reductions, frequency of monitoring, and user satisfaction compared to the previous year. The study found that participating households used around 5% less energy compared to average households. The reduction rate was found to have increased when more appliances were connected to smart plugs and their power usage was monitored more frequently. Power usage also fell in a greater level when participants were more satisfied with being given smart plugs and related education. Moreover, energy reduction rates increase when smart plugs were used for cooling and heating appliances as well as video, audio, and related devices. The results suggest that this program can be used to reduce energy use, which can be beneficial for smart homes and smart cities. The study demonstrates the importance of education from the perspective of energy conservation and related policies.
The Innovative Design of the Fire-Fighting Adapter for Forest Machinery
Authors: Hnilica Richard , Ťavodová Miroslava , Hnilicová Michaela , Matej Jaroslav , Messingerová Valéria
Published: August 2020

The presented article presents an innovative solution of a fire-fighting adapter based on the basic hypothesis: to provide sufficient technical support in difficult terrain conditions for water transport logistics in order to quickly prevent the spread and destruction of forest fire. At present, when forest fires begin, it is often quite complicated to provide sufficient technical support for the quick prevention and elimination of fires. This fact is largely eliminated by the designed fire-fighting adapter. The mentioned fire-fighting adapter can be used as a fire-fighting mobile device with a base machine of a forest wheeled skidder (LKT), part of the long-distance transport of water in difficult terrain (lake system), a water tank in difficult terrain with the possibility of filling the Bambi bag with a helicopter, part of the long-distance transport of water in the case of a difficult water source without a forest access road network, and a mobile device for emergency transportation of materials in difficult terrain. In addition to the use for fighting forest fires, the fire adapter can also be used to provide for transport of water for forest nurseries (irrigation), freshly planted areas in the event of prolonged drought, the filling of watering-places for forest animals and filling puddles in the dry season. When designing the supporting frame, we used and imitated the evolutionary approach of nature in the form of generative design. The presented paper deals with the use of modern composite materials in the design of superstructures for base machines, which gradually acquire meaning. The main reason for the increasing use of fiberglass is to achieve higher strength and safer weight reduction. This adapter is designed for forest wheel tractors that reach 40% slope availability, are able to work on the stand area, overcome obstacles and are available in sufficient quantities in all Slovak forest areas.
Growth Dynamics and Diversity of Yeasts during Spontaneous Plum Mash Fermentation of Different Varieties
Authors: Skotniczny Magdalena , Satora Paweł , Pańczyszyn Katarzyna , Cioch-Skoneczny Monika
Published: August 2020

The influence of fruit varieties on yeast ecology during spontaneous plum mash fermentation was investigated. Yeast colonies were isolated from mashes obtained from four plum varieties throughout fermentation in laboratory conditions during two consecutive years. The yeast strains were differentiated by random amplification of polymorphic DNA (RAPD-PCR) and identified by the 26S rDNA D1/D2 sequence analysis. Hanseniaspora uvarum, Metschnikowia spp. and Pichia kudriavzevii were the dominant yeasts during the early stages of plum mash fermentation, while the middle and end phases were dominated by Saccharomyces cerevisiae. The strains of Candida sake, Nakazawaea ernobii, Pichia kluyveri, Rhodotorula mucilaginosa and Wickerhamomyces anomalus were also detected in fermenting plum mashes. Metschnikowia sp. M1, H. uvarum H1 and H2 strains were detected in all samples, irrespective of the tested variety and year. Investigation of the impact of individual yeast strains on the production of volatile compounds showed the potential possibility of using them as starter cultures.
Close Binary Perspectives
Authors: Wilson R.E.
Published: August 2020

Development of analytic binary star models is discussed in historical and on-going perspective, beginning with an overview of paradigm shifts, the merits of direct (rectification-free) models, and fundamental four-type binary system morphology. Attention is called to the likelihood that many or even most cataclysmic variables may be of the double contact morphological type. Eclipsing binary distance estimates differ from those of standard candles in being individually measurable—without reliance on (usually nearby) objects that are assumed similar. Recent progress on circumstellar accretion disk models is briefly summarized, with emphasis on the separate roles of fluid dynamic, structural, and analytic models. Time-related parameters (ephemeris, apsidal motion, and light travel time) now can be found with a unified algorithm that processes light curves, velocity curves, and pre-existing eclipse timings together, without need to compute any new timings. Changes in data publication practices are recommended and logical errors and inconsistencies in terminology are noted. Parameter estimation strategies are discussed.
Nuclear Regulation of Wnt/β-Catenin Signaling: It’s a Complex Situation
Authors: Anthony Christin C. , Robbins David J. , Ahmed Yashi , Lee Ethan
Published: August 2020

Wnt signaling is an evolutionarily conserved metazoan cell communication pathway required for proper animal development. Of the myriad of signaling events that have been ascribed to cellular activation by Wnt ligands, the canonical Wnt/β-catenin pathway has been the most studied and best understood. Misregulation of Wnt/β-catenin signaling has been implicated in developmental defects in the embryo and major diseases in the adult. Despite the latter, no drugs that inhibit the Wnt/β-catenin pathway have been approved by the FDA. In this review, we explore the least understood step in the Wnt/β-catenin pathway—nuclear regulation of Wnt target gene transcription. We initially describe our current understanding of the importation of β-catenin into the nucleus. We then focus on the mechanism of action of the major nuclear proteins implicated in driving gene transcription. Finally, we explore the concept of a nuclear Wnt enhanceosome and propose a modified model that describes the necessary components for the transcription of Wnt target genes.
Christian Prayer and the Kingdom Quest: A Dialogue with Our Father across Languages and Cultures
Authors: Pennarola Cristina
Published: August 2020

Much has been written about the Our Father (also referred to as the Lord’s Prayer) as it represents a personal and public dialogue with God in daily prayer and liturgy. While its theological and spiritual aspects have been thoroughly investigated, their cultural implications for different speech communities have been disregarded. This study aims to compare the English, Italian, and French versions of the Lord’s Prayer in the Catholic Church in an attempt to examine the role that culture is bound to play in shaping religious response and tracing a preferential interpretive pathway through a sacred text. This comparative analysis is focused on lexical choice and metaphorical imagery and integrated by an examination of the wider co-text, the Bible. The analysis has shown that the versions of the Lord’s Prayer present distinctive features possibly reflective of deeply-ingrained cultural attitudes such as the appeal for elevation in the English prayer, the dual tension between deference and solidarity in the Italian prayer, and the inclination for a grand narrative of heroes and anti-heroes in the French prayer. The study concludes that renewed attention to Christian sources could help bridge the gap between religion and culture, and reconcile our spiritual and social identities in post-secular societies.
Predicting Errors, Violations, and Safety Participation Behavior at Nuclear Power Plants
Authors: Zhang Tingru , Liu Zhaopeng , Zheng Shiwen , Qu Xingda , Tao Da
Published: August 2020

Commissioning workers at nuclear power plants have long been ignored in previous studies, although their performance is closely related to the overall safety of plants. This study aimed to explain and predict three types of behavior, i.e., errors, violations, and safety participation, of commissioning workers, under the general framework of the theory of planned behavior (TPB) and by considering organization and planning factors. The validity of the model was evaluated with a sample of 167 commissioning workers who completed a self-reported questionnaire. The results showed that perceived behavioral control, along with organization and planning, significantly affected all types of behavior. It was also found that violations and errors were a direct result of attitude. Besides, errors were predicted by subjective norm; unexpectedly, this occurred in a positive way. These findings revealed the underlying mechanisms for the development of errors, violations, and safety participation among commissioning workers and provided practical implications for safety improvement at the commissioning workplace.
Pyridoxine Deficiency Exacerbates Neuronal Damage after Ischemia by Increasing Oxidative Stress and Reduces Proliferating Cells and Neuroblasts in the Gerbil Hippocampus
Authors: Jung Hyo Young , Kim Woosuk , Hahn Kyu Ri , Kang Min Soo , Kim Tae Hyeong , Kwon Hyun Jung , Nam Sung Min , Chung Jin Young , Choi Jung Hoon , Yoon Yeo Sung , Kim Dae Won , Yoo Dae Young , Hwang In Koo
Published: August 2020

We investigated the effects of pyridoxine deficiency on ischemic neuronal death in the hippocampus of gerbil (n = 5 per group). Serum pyridoxal 5′-phosphate levels were significantly decreased in Pyridoxine-deficient diet (PDD)-fed gerbils, while homocysteine levels were significantly increased in sham- and ischemia-operated gerbils. PDD-fed gerbil showed a reduction in neuronal nuclei (NeuN)-immunoreactive neurons in the medial part of the hippocampal CA1 region three days after. Reactive astrocytosis and microgliosis were found in PDD-fed gerbils, and transient ischemia caused the aggregation of activated microglia in the stratum pyramidale three days after ischemia. Lipid peroxidation was prominently increased in the hippocampus and was significantly higher in PDD-fed gerbils than in Control diet (CD)-fed gerbils after ischemia. In contrast, pyridoxine deficiency decreased the proliferating cells and neuroblasts in the dentate gyrus in sham- and ischemia-operated gerbils. Nuclear factor erythroid-2-related factor 2 (Nrf2) and brain-derived neurotrophic factor (BDNF) levels also significantly decreased in PDD-fed gerbils sham 24 h after ischemia. These results suggest that pyridoxine deficiency accelerates neuronal death by increasing serum homocysteine levels and lipid peroxidation, and by decreasing Nrf2 levels in the hippocampus. Additionally, it reduces the regenerated potentials in hippocampus by decreasing BDNF levels. Collectively, pyridoxine is an essential element in modulating cell death and hippocampal neurogenesis after ischemia.
The Arabidopsis RboHB Encoded by At1g09090 Is Important for Resistance against Nematodes
Authors: Hawamda Abdalmenem I. M. , Zahoor Adil , Abbas Amjad , Ali Muhammad Amjad , Bohlmann Holger
Published: August 2020

Reactive oxygen species are a byproduct of aerobic metabolic processes but are also produced by plants in defense against pathogens. In addition, they can function as signaling molecules that control various aspects of plant life, ranging from developmental processes to responses to abiotic and biotic stimuli. In plants, reactive oxygen species can be produced by respiratory burst oxidase homologues. Arabidopsis contains 10 genes for respiratory burst oxidase homologues that are involved in different aspects of plant life. Plant pathogenic cyst nematodes such as Heterodera schachtii induce a syncytium in the roots of host plants that becomes a feeding site which supplies nutrients throughout the life of the nematode. In line with this function, the transcriptome of the syncytium shows drastic changes. One of the genes that is most strongly downregulated in syncytia codes for respiratory burst oxidase homologue B. This gene is root-specific and we confirm here the downregulation in nematode feeding sites with a promoter::GUS (β-glucuronidase) line. Overexpression of this gene resulted in enhanced resistance against nematodes but also against leaf-infecting pathogens. Thus, respiratory burst oxidase homologue B has a role in resistance. The function of this gene is in contrast to respiratory burst oxidase homologues D and F, which have been found to be needed for full susceptibility of Arabidopsis to H. schachtii. However, our bioinformatic analysis did not find differences between these proteins that could account for the opposed function in the interaction with nematodes.
A Re-Appraisal of Pathogenic Mechanisms Bridging Wet and Dry Age-Related Macular Degeneration Leads to Reconsider a Role for Phytochemicals
Authors: Pinelli Roberto , Biagioni Francesca , Limanaqi Fiona , Bertelli Miorica , Scaffidi Elena , Polzella Maico , Busceti Carla Letizia , Fornai Francesco
Published: August 2020

Which pathogenic mechanisms underlie age-related macular degeneration (AMD)? Are they different for dry and wet variants, or do they stem from common metabolic alterations? Where shall we look for altered metabolism? Is it the inner choroid, or is it rather the choroid–retinal border? Again, since cell-clearing pathways are crucial to degrade altered proteins, which metabolic system is likely to be the most implicated, and in which cell type? Here we describe the unique clearing activity of the retinal pigment epithelium (RPE) and the relevant role of its autophagy machinery in removing altered debris, thus centering the RPE in the pathogenesis of AMD. The cell-clearing systems within the RPE may act as a kernel to regulate the redox homeostasis and the traffic of multiple proteins and organelles toward either the choroid border or the outer segments of photoreceptors. This is expected to cope with the polarity of various domains within RPE cells, with each one owning a specific metabolic activity. A defective clearance machinery may trigger unconventional solutions to avoid intracellular substrates’ accumulation through unconventional secretions. These components may be deposited between the RPE and Bruch’s membrane, thus generating the drusen, which remains the classic hallmark of AMD. These deposits may rather represent a witness of an abnormal RPE metabolism than a real pathogenic component. The empowerment of cell clearance, antioxidant, anti-inflammatory, and anti-angiogenic activity of the RPE by specific phytochemicals is here discussed.