bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 12 from Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer
Authors: Tsimberidou Apostolia M. , Guenther Kerstin , Andersson Borje S. , Mendrzyk Regina , Alpert Amir , Wagner Claudia , Nowak Anna , Aslan Katrin , Satelli Arun , Richter Fabian , Kuttruff-Coqui Sabrina , Schoor Oliver , Fritsche Jens , Coughlin Zoe , Mohamed Ali S. , Sieger Kerry , Norris Becky , Ort Rita , Beck Jennifer , Vo Henry Hiep , Hoffgaard Franziska , Ruh Manuel , Backert Linus , Wistuba Ignacio I. , Fuhrmann David , Ibrahim Nuhad K. , Morris Van Karlyle , Kee Bryan K. , Halperin Daniel M. , Nogueras-Gonzalez Graciela M. , Kebriaei Partow , Shpall Elizabeth J. , Vining David , Hwu Patrick , Singh Harpreet , Reinhardt Carsten , Britten Cedrik M. , Hilf Norbert , Weinschenk Toni , Maurer Dominik , Walter Steffen
Published: July 2023

Supplementary Figure 12
Supplemental Figure 6 from Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer
Authors: Tsimberidou Apostolia M. , Guenther Kerstin , Andersson Borje S. , Mendrzyk Regina , Alpert Amir , Wagner Claudia , Nowak Anna , Aslan Katrin , Satelli Arun , Richter Fabian , Kuttruff-Coqui Sabrina , Schoor Oliver , Fritsche Jens , Coughlin Zoe , Mohamed Ali S. , Sieger Kerry , Norris Becky , Ort Rita , Beck Jennifer , Vo Henry Hiep , Hoffgaard Franziska , Ruh Manuel , Backert Linus , Wistuba Ignacio I. , Fuhrmann David , Ibrahim Nuhad K. , Morris Van Karlyle , Kee Bryan K. , Halperin Daniel M. , Nogueras-Gonzalez Graciela M. , Kebriaei Partow , Shpall Elizabeth J. , Vining David , Hwu Patrick , Singh Harpreet , Reinhardt Carsten , Britten Cedrik M. , Hilf Norbert , Weinschenk Toni , Maurer Dominik , Walter Steffen
Published: July 2023

Supplemental Figure 6
Supplemental Figure 4 from Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer
Authors: Tsimberidou Apostolia M. , Guenther Kerstin , Andersson Borje S. , Mendrzyk Regina , Alpert Amir , Wagner Claudia , Nowak Anna , Aslan Katrin , Satelli Arun , Richter Fabian , Kuttruff-Coqui Sabrina , Schoor Oliver , Fritsche Jens , Coughlin Zoe , Mohamed Ali S. , Sieger Kerry , Norris Becky , Ort Rita , Beck Jennifer , Vo Henry Hiep , Hoffgaard Franziska , Ruh Manuel , Backert Linus , Wistuba Ignacio I. , Fuhrmann David , Ibrahim Nuhad K. , Morris Van Karlyle , Kee Bryan K. , Halperin Daniel M. , Nogueras-Gonzalez Graciela M. , Kebriaei Partow , Shpall Elizabeth J. , Vining David , Hwu Patrick , Singh Harpreet , Reinhardt Carsten , Britten Cedrik M. , Hilf Norbert , Weinschenk Toni , Maurer Dominik , Walter Steffen
Published: July 2023

Supplemental Figure 4
Supplementary Figures from High Expression of MHC Class I Overcomes Cancer Immunotherapy Resistance Due to IFNγ Signaling Pathway Defects
Authors: Kawase Katsushige , Kawashima Shusuke , Nagasaki Joji , Inozume Takashi , Tanji Etsuko , Kawazu Masahito , Hanazawa Toyoyuki , Togashi Yosuke
Published: July 2023

Supplementary Figure S1-S7
Supplementary Figure 7 from MYC Induces Immunotherapy and IFNγ Resistance Through Downregulation of JAK2
Authors: Markovits Ettai , Harush Ortal , Baruch Erez N. , Shulman Eldad D. , Debby Assaf , Itzhaki Orit , Anafi Liat , Danilevsky Artem , Shomron Noam , Ben-Betzalel Guy , Asher Nethanel , Shapira-Frommer Ronnie , Schachter Jacob , Barshack Iris , Geiger Tamar , Elkon Ran , Besser Michal J. , Markel Gal
Published: July 2023

Supplementary Figure 7
Supplementary Figure 2 from MYC Induces Immunotherapy and IFNγ Resistance Through Downregulation of JAK2
Authors: Markovits Ettai , Harush Ortal , Baruch Erez N. , Shulman Eldad D. , Debby Assaf , Itzhaki Orit , Anafi Liat , Danilevsky Artem , Shomron Noam , Ben-Betzalel Guy , Asher Nethanel , Shapira-Frommer Ronnie , Schachter Jacob , Barshack Iris , Geiger Tamar , Elkon Ran , Besser Michal J. , Markel Gal
Published: July 2023

Supplementary Figure 2
Supplemental Table 4 from mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity
Authors: Nirschl Christopher J. , Brodkin Heather R. , Domonkos Celesztina , Dwyer Connor J. , Hicklin Daniel J. , Ismail Nesreen , Seidel-Dugan Cynthia , Steiner Philipp , Steuert Zoe , Sullivan Jenna M. , Winston William M. , Salmeron Andres
Published: July 2023

Z Scores from EMT-6 Tumor Infiltrating CD8+ T cells from Select Pathways
Supplementary Fig. 5-7 from KRT17 Promotes T-lymphocyte Infiltration Through the YTHDF2–CXCL10 Axis in Colorectal Cancer
Authors: Liang Wenfeng , Liu Huashan , Zeng Ziwei , Liang Zhenxing , Xie Hao , Li Wenxin , Xiong Li , Liu Zhihang , Chen Mian , Jie Haiqing , Zheng Xiaobin , Huang Liang , Kang Liang
Published: July 2023

YTHDF2 expression is negatively correlated with CD3+ and CD8+ densities in tumor parenchyma and invasive margin in CRC.
Supplementary Fig. 2 from KRT17 Promotes T-lymphocyte Infiltration Through the YTHDF2–CXCL10 Axis in Colorectal Cancer
Authors: Liang Wenfeng , Liu Huashan , Zeng Ziwei , Liang Zhenxing , Xie Hao , Li Wenxin , Xiong Li , Liu Zhihang , Chen Mian , Jie Haiqing , Zheng Xiaobin , Huang Liang , Kang Liang
Published: July 2023

KRT17 has no effect on proliferation, migration and invasion of CRC cells.
Supplementary Fig. 1 from KRT17 Promotes T-lymphocyte Infiltration Through the YTHDF2–CXCL10 Axis in Colorectal Cancer
Authors: Liang Wenfeng , Liu Huashan , Zeng Ziwei , Liang Zhenxing , Xie Hao , Li Wenxin , Xiong Li , Liu Zhihang , Chen Mian , Jie Haiqing , Zheng Xiaobin , Huang Liang , Kang Liang
Published: July 2023

KRT17 is highly expressed in CRC tissues compared to tumor-adjacent tissue regardless of MMR status.
Supplementary Data from IL12/18/21 Preactivation Enhances the Antitumor Efficacy of Expanded γδT Cells and Overcomes Resistance to Anti–PD-L1 Treatment
Authors: Teo Huey Yee , Song Yuan , Yong Kylie Su Mei , Liu Yonghao , Mei Yu , Hanafi Zuhairah Binte , Zhu Ying , Chua Yen Leong , Gascoigne Nicholas R.J. , Chen Qingfeng , Liu Haiyan
Published: July 2023

Supplementary Figures and Table
Supplementary Protocol from A Phase Ib/II Study of Ivosidenib with Venetoclax ± Azacitidine in IDH1-Mutated Myeloid Malignancies
Authors: Lachowiez Curtis A. , Loghavi Sanam , Zeng Zhihong , Tanaka Tomoyuki , Kim Yi June , Uryu Hidetaka , Turkalj Sven , Jakobsen Niels Asger , Luskin Marlise R. , Duose Dzifa Y. , Tidwell Rebecca S.S. , Short Nicholas J. , Borthakur Gautam , Kadia Tapan M. , Masarova Lucia , Tippett George D. , Bose Prithviraj , Jabbour Elias J. , Ravandi Farhad , Daver Naval G. , Garcia-Manero Guillermo , Kantarjian Hagop , Garcia Jacqueline S. , Vyas Paresh , Takahashi Koichi , Konopleva Marina , DiNardo Courtney D.
Published: July 2023

Supplementary protocol for "Phase Ib/II Investigator Initiated Study of the IDH1-mutant inhibitor ivosidenib (AG120) with the BCL2 inhibitor venetoclax +/- azacitidine in IDH1-mutated hematologic malignancies"
Supplementary Figures 1-8 from Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia
Authors: Kotini Andriana G. , Carcamo Saul , Cruz-Rodriguez Nataly , Olszewska Malgorzata , Wang Tiansu , Demircioglu Deniz , Chang Chan-Jung , Bernard Elsa , Chao Mark P. , Majeti Ravindra , Luo Hanzhi , Kharas Michael G. , Hasson Dan , Papapetrou Eirini P.
Published: July 2023

Supplemental Figure 1. Generation of a panel of iPSCs from patients with AML.
Supplemental Figure 2. Reprogramming aids reconstruction of the evolutionary history and clonal composition of AML.
Supplemental Figure 3. Transplantation of AML-iPSCs into immunodeficient mice.
Supplemental Figure 4. Developmental block in a subset of AML-iPSC lines.
Supplemental Figure 5. Transplantation of primary AML cells and patient-matched AMLiPSC lines.
Supplemental Figure 6. Single-cell RNA-sequencing analyses of matched primary and iPSC-derived leukemia cells from patient AML-47.
Supplemental Figure 7. Cell cycle and pseudotime analyses.
Supplemental Figure 8. Comparison of scRNA-Seq data integration and clustering methods and pseudobulk differential gene expression analyses.
Queer and using substances, a ‘double whammy’: results from a needs assessment of substance use treatment professionals in South Africa
Authors: Tao Summer , Jacobs Liezille
Published: July 2023

This study explored the training needs of substance use disorder (SUD) treatment practitioners in relation to their readiness in treating queer clients. We conducted a series of semi-structured interviews ( N = 7) based in the Western Cape of South Africa. A thematic analysis identified themes related to treatment structures developed for a binary perception of gender, the burden of discrimination borne by queer clients that may impede treatment, and practitioner interest in further training and development. Our findings suggest that SUD treatment practitioners do not feel fully prepared to treat queer clients and are aware of a need for gender-sensitive training in this area. Improvements to practitioner training and readiness could yield benefits for both clients and practitioners within the treatment space.
Coordinated control of longitudinal and lateral movements considering dynamics for distributed drive electric vehicle platoon on curved roads
Authors: Fang Ting , Wang Qidong , Zhao Linfeng , Chen Wuwei , Yan Mingyue , Cai Bixin
Published: July 2023

The control goal of the vehicle platoon is to maintain the same speed and desired distance. Most current studies are based on simplified vehicle models, and the leader’s state is also rarely considered. However, under complex working conditions, such as low adhesion or curves, the lateral stability of the platoon will be difficult to guarantee, and tracking errors of desired speed and spacing may further increase. To solve the above problems, a new hierarchical coordinated control strategy is proposed. Taking distributed drive electric vehicles (DDEVs) as research objects, the upper control level establishes a stability situation assessment model according to the vehicle’s dynamic characteristics. At the medium control level, variable weight model predictive control (MPC) coordinates conflicts between longitudinal tracking and lateral stability. A correction term is also introduced to revise the prediction model. At the same time, the weight of different control objectives of the leader and following vehicle was adjusted, respectively. Torque distribution is carried out at the lower level controller. Finally, the control strategy is tested on a hardware-in-the-loop (HIL) platform. The results show that the proposed control strategy can ensure lateral stability while improving the tracking performance of the vehicle platoon.
Making space for the new state capitalism, part III: Thinking conjuncturally
Authors: Dixon Adam D , Peck Jamie , Alami Ilias , Whiteside Heather
Published: July 2023

The theme issue “Making Space for the New State Capitalism” brings together insights from critical economic geography and heterodox political economy through a series papers published in three installments, each accompanied with an introductory essay written by the guest editors. In this, the third of these introductory commentaries, we explore the challenges and opportunities associated with thinking conjuncturally, followed by a final collection of papers.
Model for Managing Divert Risk Caused by Low Visibility in Airline Operations Management
Authors: Akbaba Ali
Published: July 2023

In airline operations management, one can state that because of meteorological conditions, flights may have to land at an appropriate alternate airport instead of the destination. One of these meteorological conditions can be reported as insufficient visibility. In this study, I aimed to develop a model for making the most optimal flight decision by following the decision-making process with respect to risk assessment using historical meteorological data when visibility poses a risk of diverting in forecasts. I formed a standard decision-making process flowchart model for a certain period based on costs by making implementing a flight schedule relating to divert risk caused by low visibility. For this research, the risk assessment was made by analyzing the past meteorological data of the destination airport. Then the decision-making process in airline operation management was implemented in line with the data obtained. Based on the study’s results, a model for airlines’ risk analysis in managing operations with divert risk caused by low visibility has been reported to make more optimum decisions in operation.
Research on blade statistics measurement registration planning technology
Authors: Zhang Yun , Xu Zhiyong , Liu Jingqing , Chen Zhitong , Zhu Zhengqing
Published: July 2023

Blade has the characteristics of high machining quality of complex curved surface. If there is no benchmark before machining, it is impossible to judge whether the blades before machining are qualified. Therefore, it is necessary to analyze the blade measurement data. Due to the large measurement point error and disordered distribution, it is necessary to optimize the blade registration. Therefore, blade model registration and positioning is particularly important in blade shape detection and analysis. First, preregistration is carried out based on the six point optimization selection of the blade. After preregistration, the selection method of registration control point set based on theoretical model and statistical error is proposed, planning the registration datum point set on the blade model. The registration control point set is obtained through the registration operation between the measurement data and the registration reference point set. Finally, based on the stability and reliability of important sampling sensitivity and statistical error, obtain the probability density function of error normal distribution statistics samples and important samples. The selection of statistical control points and the rationality of the objective function were verified. The stability/reliability of the statistical alignment point selection is proved to be feasible. The statistical registration deviation is [0.015,0.026] mm, and the ICP registration deviation is [0.031,0.035] mm. The average deviation of statistics registration is about 0.013 mm smaller than the average deviation of ICP registration. The deviation of statistical sampling points is about 0.0214 mm, and that of traditional sampling points is about 0.0275 mm. The deviation of statistical sampling points is about 0.0061 mm smaller than that of traditional sampling points. It meets the requirements of rapid, high efficiency and high precision measurement for aeroengine blades.
Finite element analysis (FEA) of femur to predict biomechanical properties and its validation
Authors: Gujar Rahul , Warhatkar Hemant , Kale Amit
Published: July 2023

The aim of this preliminary study is to predict the biomechanical properties as strain of the femur using computed tomography medical image-based finite element analysis. Further, the finite element results were compared with the experimental results for validation purpose. The main objective of the study was to establish and validate a finite element model used to analyse biomechanical properties. For this, four sheep femur specimens were used to predict normal strain in x-x direction. Computed tomography scans were taken from each femur sample. Subsequently, an accurate image-based 3D model of each femur specimen was segmented and reconstructed with its material properties. Furthermore, the experimental test was performed at 8° bone inclination in the coronal plane and a compressive load was applied at displacement rate of 0.2 mm/s to the femur head in a vertical downward direction until fracture. Consequently, the numerical results of predicted normal strain were compared with the experimental measured normal strain. The average deviation between finite element and experimental results was found to be −11.11%–20.10% in strains. Hence, it is concluded that the results obtained using finite element analysis are in good agreement with the experimental results.
Scale Up of Neonatal Resuscitation Training and Skill Retention in Five Provinces of Nepal
Authors: Clark Robert Brent , Dhungana Ranjan , Chalise Mala , Visick Michael Keane
Published: July 2023

To reduce neonatal mortality attributable to intrapartum hypoxic events, Latter-days Saint Charities (LDSC) and Safa Sunaulo Nepal (SSN) implemented a neonatal resuscitation training, scale-up, and skill retention program. This article reports on the LDSC/SSN dissemination program and newborn outcomes associated with its implementation. To evaluate the program, we used a prospective cohort design to compare outcomes of birth cohorts in 87 health facilities preimplementation and postimplementation of the facility-based training. A paired T-test was used to determine whether baseline and endline values were significantly different. Resuscitation training began with trainers from 191 facilities attending Helping Babies Breathe (HBB) training-of-trainer (ToT) courses. Thereafter, 87 facilities from five provinces received active mentoring, scale-up assistance (6389 providers trained), and skill retention support. The LDSC/SSN program was associated with decreases in the number of intrapartum stillbirths in all provinces except Bagmati. Neonatal deaths within 24 hours of birth decreased significantly in Lumbini, Madhesh, and Karnali provinces. Morbidity associations, as defined by sick newborn transfers, decreased significantly in Lumbini, Gandaki, and Madhesh provinces. The LDSC/SSN model of neonatal resuscitation training, scale-up, and skill retention has the potential to significantly improve perinatal outcomes. It could potentially guide future programs in Nepal and other resource-limited settings.
The Quality of Dying in Frail Institutionalized Older Patients After Nonoperative and Operative Management of a Proximal Femoral Fracture: An In-Depth Analysis
Authors: Loggers Sverre A. I. , Van Balen Romke , Willems Hanna C. , Gosens Taco , Polinder Suzanne , Ponsen Kornelis J. , Van de Ree Cornelis L. P. , Steens Jeroen , Verhofstad Michael H. J. , Zuurmond Rutger G. , Joosse Pieter , Van Lieshout Esther M. M.
Published: July 2023

Proximal femoral fractures in frail patients have a poor prognosis. Despite the high mortality, little is known about the quality of dying (QoD) while this is an integral part of palliative care and could influence decision making on nonoperative- (NOM) or operative management (OM). To identify the QoD in frail patients with a proximal femoral fracture. Data from the prospective FRAIL-HIP study, that studied the outcomes of NOM and OM in institutionalized older patients ≥70 years with a limited life expectancy who sustained a proximal femoral fracture, was analyzed. This study included patients who died within the 6-month study period and whose proxies evaluated the QoD. The QoD was evaluated with the Quality of Dying and Death (QODD) questionnaire resulting in an overall score and 4 subcategory scores (Symptom control, Preparation, Connectedness, and Transcendence). In total 52 (64% of NOM) and 21 (53% of OM) of the proxies responded to the QODD. The overall QODD score was 6.8 (P25-P75 5.7-7.7) (intermediate), with 34 (47%) of the proxies rating the QODD ‘good to almost perfect’. Significant differences in the QODD scores between groups were not noted (NOM; 7.0 (P25-P75 5.7-7.8) vs OM; 6.6 (P25-P75 6.1-7.2), P = .73). Symptom control was the lowest rated subcategory in both groups. The QoD in frail older nursing home patients with a proximal femoral fracture is good and humane. QODD scores after NOM are at least as good as OM. Improving symptom control would further increase the QoD.
Disability Caused by Cleft Lip and Palate: A Systematic Review and Critical Valuation Appraisal
Authors: Blum Jessica D. , Benítez Diana Bohórquez , Caballero Felix Robles , Villavisanis Dillan F. , Cho Daniel Y. , Bartlett Scott P. , Taylor Jesse A. , Magee Leanne , Sierra Nicolas E. , Swanson Jordan W.
Published: July 2023

Objective

Measuring disability as a concept of impaired global function enables beneficiaries of treatment, the impact of treatment, and targets of health system investment to be rigorously assessed. Measures of disability are not well established for cleft lip and palate. This study aims to systematically review disability weight (DW) studies pertaining to orofacial clefts (OFCs) and identify methodological strengths and shortcomings of each approach.

Design

Systematic literature review of studies that met the following criteria: (1) peer-reviewed publication, (2) focus on disability valuation, (3) mention orofacial clefts, and (4) publication January 2001-December 2021.

Setting

None.

Patients/Participants

None.

Interventions

None.

Main Outcome Measure(s)

Disability weight method of valuation and the value itself.

Results

The final search strategy yielded 1,067 studies. Seven manuscripts were ultimately included for data extraction. The disability weights used in our studies, including those newly generated or taken from the Global Burden of Disease Studies (GBD), ranged widely for isolated cleft lip (0.0–0.100) and cleft palate with or without cleft lip (0.0−0.269). The GBD studies limited their consideration of cleft sequelae informing disability weights to impact on appearance and speech-related concerns, while other studies accounted for comorbidities such as pain and social stigma.

Conclusions

Current measures of cleft disability are sparse, inadequately reflect the comprehensive impact of an OFC on function and socialization, and are limited in detail or supporting evidence. Use of a comprehensive health state description in evaluating disability weights offers a realistic means of accurately representing the diverse sequelae of an OFC.
Anaplastic Kaposi Sarcoma of the Right Colon, in a Young Man With Acquired Immunodeficiency Syndrome: A Rare Variant in an Unreported Organ
Authors: Herrera-Goepfert Roberto , Volkow Patricia , Ochoa-Murillo Manoella
Published: July 2023

Kaposi sarcoma (KS) arises in the context of 4 epidemiologic-clinical settings: Classic, endemic, epidemic, and iatrogenic; the most serious types are endemic and epidemic, and visceral involvement occurs mostly in the latter. Several morphological variants of KS have been described, of which the anaplastic one is highly aggressive. We report the case of an anaplastic KS arising from the ascending colon in a 32-year-old human immunodeficiency virus (HIV)-positive male patient with a 6-year history of multiple mucocutaneous KS. Anaplastic KS is most frequent in endemic and classic settings; there are ten cases of anaplastic KS reported in HIV-positive male patients. There is now strong evidence that KS is a clonal neoplasm characterized by chromosomal instability at the molecular level. According to the morphological spectrum and contemporary hypotheses of oncogenesis, conventional KS should be considered an incipient endothelial neoplasia, multiple or single, and anaplastic KS, the fully developed stage of the malignant neoplasm.
The Importance of Cajal’s and Lorente de Nó’s Neuroscience to the Birth of Cybernetics
Authors: Espinosa-Sanchez Juan Manuel , Gomez-Marin Alex , de Castro Fernando
Published: July 2023

The beginnings of cybernetics were marked by the publication of two papers in 1943. In the first one, Rosenblueth, Wiener, and Bigelow claimed that purposeful behavior is a circular process controlled by negative feedback. In the second seminal paper, McCulloch and Pitts proposed that neurons are interconnected working as logical operators. Both articles raised human-machine analogies and mathematically formulated cognitive mechanisms. These ideas ignited the interest of von Neumann, who was developing the first stored-program computer. Thus, after a preliminary meeting in 1945, a series of meetings were held between 1946 and 1953. The role of the Spanish neurophysiologist Rafael Lorente de Nó in the beginnings of cybernetics is attested not only by his participation in the core members of these Macy conferences but also for his previous description of reverberating circuits formed by a closed chain of internuncial neurons. This was the first neurobiologic demonstration of a feedback loop. Most researchers considered the central nervous system as a mere reflex organ until then; nevertheless, he demonstrated a self-sustained central activity in the nervous system, supporting the idea of self-regulating mechanisms as a key concept not just in machines but also in the brain.
Cigarette Smoke Exposure and Stunting Among Under-five Children in Rural and Poor Families in Indonesia
Authors: Muchlis Nurmiati , Yusuf Rezky Aulia , Rusydi Arni Rizqiani , Mahmud Nur Ulmy , Hikmah Nurul , Qanitha Andriany , Ahsan Abdillah
Published: July 2023

Cigarette smoke exposure in mothers and children is highly prevalent in Asia, especially among rural and poor families. Second-hand smoke exposure might affect the nutritional status of children. Despite the emerging double burden of malnutrition and the very high prevalence of smoking in Indonesia, few studies have examined the effects of parental smoking on children’s nutritional status. This study aims to measure the relationship between family smoking behavior and the occurrence of stunting in children under 5 years. This cross-sectional study used a purposive sampling technique, with 221 households with children aged 0 to 59 months from poor areas in Indonesia. Exposure to cigarette smoke is assessed using The Secondhand Smoke Exposure Scale questionnaire. The outcome measured is child stunting (height-for-age Z-score). The prevalence of stunting was estimated at 145 (65.6%). Children living with smoking parents were counted for 157 (71%), and most smoking exposure comes from fathers 147 (67.4%). The predictors of stunting in children under 5 years were a smoker father with (AOR 1.8; 95% CI 1.281-4.641), both parents are smokers increasing the risk of stunting with (COR 3.591; 95% CI 1.67-3.77), being exposed of smoke for more than 3 hours a day increase the risk of stunted children (COR 2.05; 95% CI 1.214-3.629), and using traditional cigarette or kretek expand the risk of stunting (AOR 3.19; 95% CI 1.139-67.785). The findings demonstrate the negative impact of parental smoking on children’s growth, reinforcing the importance of reducing smoking prevalence by imposing a smoke-free home policy in the stunting prevention strategy.
Advancing Inclusion of Transgender and Gender-Diverse Identities in Clinical Education: A Toolkit for Clinical Educators
Authors: Linsenmeyer Whitney , Heiden-Rootes Katie , Drallmeier Theresa , Rahman Rabia , Buxbaum Emily , Rosen Willow , Gombos Beth , Otte Ashton
Published: July 2023

Clinical education programs are positioned to train future health care professionals to provide excellent health care for transgender and gender-diverse patients. The purpose of this resource, Advancing Inclusion of Transgender and Gender-Diverse Identities in Clinical Education: A Toolkit for Clinical Educators, is to facilitate critical inquiry among clinical educators regarding their approach to teaching about sex, gender, the historical and sociopolitical context of transgender health, and how to prepare their students to apply standards of care and clinical care guidelines set forth by national and international professional organizations.
A technology-based experience to improve badminton skills: A challenge-based learning application
Authors: González-Peño Alba , Simón-Chico Luis , Prieto Leonor , Franco Evelia
Published: July 2023

In recent years, it has become evident that technologies are part of daily life and can be useful and helpful to improve teaching and learning processes in education. Specifically, this evidence has highlighted the positive effect of technologies on improving motor skills. This study presents a technology-based learning (TBL) proposal and analyses how the implementation of such a proposal in physical education (PE) might affect students’ academic performance (theoretical knowledge and practical competence). A quasi-experimental study was carried out with experimental and control groups. A total of 84 participants (35 males and 49 females) between 13 and 15 years of age ( Mage = 13.35, SD = 0.62) took part in the experience over a period of 6 weeks ( ncontrol = 49; nexperimental = 35). The teacher assessed students’ practical competence level in both the experimental and control groups to verify homogeneity. Theoretical knowledge and badminton-specific motor skill tests were performed in both groups after the intervention. Analysis showed that, after the intervention, students in the TBL group significantly increased their levels of badminton-specific motor skills ( Mcontol = 7.01 vs Mexperimental = 7.73) compared with students in the control group. No significant changes were observed for theoretical knowledge. The findings of this study highlight that the integration of technologies in PE might be a valid and effective methodological approach for PE students to achieve adaptive learning outcomes and improve their academic performance.
Comparing ART outcomes in women with endometriosis after GnRH agonist versus GnRH antagonist ovarian stimulation: a systematic review
Authors: Kuan Kevin K.W. , Omoseni Sean , Tello Javier A.
Published: July 2023

Background:

Endometriosis is an oestrogen-dependent disease that can cause subfertility in women who may require assisted reproductive technology (ART) to achieve their pregnancy goals.

Objectives:

The aim of this study was to compare ART outcomes in women with endometriosis following the long GnRH-agonist controlled ovarian stimulation (COS) protocol with those taking the GnRH-antagonist COS protocol.

Data Sources and Methods:

MEDLINE, Embase and Web of Science were systematically searched in June 2022. Randomized controlled trials (RCTs) and observational studies comparing the long GnRH-agonist COS protocol and the GnRH-antagonist COS protocol in women with all stages/subtypes of endometriosis were included. Data were synthesized into comprehensive tables for systematic review. The Scottish Intercollegiate Guidelines Network (SIGN) checklists were used for the risk of bias assessment of non-randomized studies and randomized studies, and all the included studies were deemed to have acceptable quality.

Main Results:

Eight studies (one RCT and seven observational) with 2695 patients (2761 cycles) were included. Most studies generally reported non-significant differences in clinical pregnancy or live birth rates regardless of the COS protocol used. However, the GnRH-agonist protocol may yield a higher total number of oocytes retrieved, especially mature oocytes. Conversely, the GnRH-antagonist protocol required a shorter COS duration and lower gonadotrophin dose. Adverse outcomes, such as rates of cycle cancellation and miscarriage, were similar between both COS protocols.

Conclusion:

Both the long GnRH-agonist and GnRH-antagonist COS protocols generally yield similar pregnancy outcomes. However, the long GnRH-agonist protocol may be associated with a higher cumulative pregnancy rate due to the higher number of retrieved oocytes available for cryopreservation. The underlying mechanisms of the two COS protocols on the female reproductive tract remain unclear. Clinicians should consider treatment costs, stage/subtype of endometriosis and pregnancy goals of their patients when selecting a GnRH analogue for COS. A well-powered RCT is needed to minimize the risk of bias and compare the risk for ovarian hyperstimulation syndrome.

Registration:

This review was prospectively registered at PROSPERO under Registration No. CRD42022327604.
In the name of Asian solidarity: Sino–Japanese competition for technology diplomacy in Burma, 1955–1965
Authors: Wu Bohao
Published: July 2023

A decade after the 1955 Bandung Conference, China and Japan engaged in a competition for technological exports to Burma. 1 During this process, technocrats in Beijing and Tokyo mobilized non-governmental collaborators—local Chinese industrialists and Japanese businesses seeking overseas expansion—as proxies to maximize their technological output to Burma. The Burmese, on the other hand, used the competition between Beijing and Tokyo as a bargaining tool, and pressed the two regional powers to provide at Rangoon's request. The technical aid Burma received was also affected by its shifting visions for development. Factionalist struggles between 1958 and 1962 changed not only Burma's political landscape but also its leadership's mind-set regarding the economy: the nation moved away from aid-driven industrial modernization towards a self-reliant, agricultural economy based on limited foreign technologies. Consequently, the meaning of the term ‘technological aid’, though used throughout the decade, became flexible and indistinct, carrying vastly different connotations at different stages of the Burmese state-building process. In this way, Burma's experience as an aid-receiving country in Cold War Asia may speak to the flexible power dynamics between the aiding and the aided countries, and shed light on the diversified means through which states employed science and technology as diplomatic tools in Cold War competition.
Effect of COVID-19 Frontline Nurses’ Profession Perception on Their Intention to Stay: The Mediating Role of Job Satisfaction
Authors: Im Ahram , Koh Chin Kang
Published: July 2023

Introduction

Understanding the factors affecting the intention of frontline nurses during the coronavirus disease (COVID-19) pandemic to stay in the nursing profession is essential for developing strategies to overcome the challenges associated with the pandemic.

Objectives

This study aimed to examine the mediating effect of nurses’ job satisfaction on the relationship between their sense of calling, job-esteem, and the intention to stay in their profession.

Methods

The study used a previously collected dataset, sourced from a dedicated COVID-19 hospital in Seoul City, South Korea. Original data were collected from June to July 2021. The study sample consisted of 134 nurses who provided direct care to patients. The intention to stay was measured with the following question: “Are you willing to work during this COVID-19 pandemic?”. The Job Satisfaction Scale from the Korean Labor and Income Panel Study, Korean version of a Multidimensional Calling Measure, and Job-Esteem Scale for Hospital Nurses were utilized. Associations between the study variables were estimated using bivariate correlation analyses and bootstrapping mediation analyses.

Results

In the bivariate correlation analysis, nurses’ sense of calling ( r = .36, p < .001), job-esteem ( r = .32, p < .001), and job satisfaction ( r = .39, p < .001) were significantly associated with the intention to stay. In the mediation analysis, job satisfaction partially mediated the relationship between the sense of calling and the intention to stay (total effect; B = 0.410, p < .001) and fully mediated the relationship between job-esteem and the intention to stay (total effect; B = 0.549, p < .001).

Conclusion

Enhancing nurses’ job satisfaction is crucial for fostering the retention of the nursing workforce amid the pandemic. Consequently, it is imperative to closely examine the job satisfaction and work environment of frontline nurses to identify areas in need of improvement. Addressing the factors that impede nurses’ job satisfaction is essential to unlock the positive effects of a sense of calling and job-esteem.
Health Sector Development in India: An Account from Bhore Committee 1946 to National Health Policy 2017
Authors: Dehury Ranjit Kumar , Dehury Parthsarathi , Sripathi Nischala , Acharyulu GVRK , Behera Manas Ranjan , Neeragatti Suryanarayana
Published: July 2023

Many ideas were implemented to protect the health of Indian citizens and refugees, rural and urban population, young and old, and men and women over several decades. Some of the policies are translated to programmes in the ground level and help improve the measurable rates and ratios of the health system successfully. There is an improvement in life expectancy at birth, reduction of child mortality and maternal mortality, control, and reduction of epidemics over a period spanning more than seven decades post-independence. However, the comparison of the health achievement of India with the global south and north brings much disparity in the achievement rates, of which India clearly belongs to the global south. This article highlights many salient features of relevant healthcare policies and the progress thereof in the crucible of time. The article discusses the key historical developments in the Bhore Committee report 1946, Planning Commission of India, Alma Atta Declaration 1978, Health for All by 2000, National health policy 2002, High-Level Expert Group Report 2011, National Health Policy 2017, Astana Declaration 2017, and Prime Ministers Jan Arogya Yojna 2018, along with other policy documents having a strong bearing on the healthcare system of India.
Integrating computational thinking into primary mathematics: A case study of fraction lessons with Scratch programming activities
Authors: Fang Xiaoxuan , Ng Davy Tsz Kit , Tam Wing Tung , Yuen Manwai
Published: July 2023

We presented a design-based study within the context of a four-session Scratch programming activity among 23 fourth-grade students in Hong Kong. Inspired by the computational thinking (CT) strategies and the 5E instructional model, we investigated students’ mathematical learning of fractions in a Scratch (block-based programming) environment. Students developed CT concepts, practices, and perspectives by building a “fraction magic calculator” in groups. This study analyzed the lesson design, students’ drawings, interviews, and work expressing their mathematical understanding of fractions in Scratch applications. The learning tasks were designed to support the students’ fraction learning and utilized computational abstractions in the form of variables, functions, and iterations to formulate mathematical models in a programming context. Students’ artifacts and feedback showed they were interested in learning fractions in a programming learning context, contributing to exercising and improving their fraction concepts and CT. Ultimately, we emphasized the benefits of CT integrated into mathematics education, promoting students’ understanding of fraction concepts, a set of CT abilities (concepts, practices, perspectives), and learning motivation. Moreover, we suggested a set of non-cognitive skills (e.g., socializing, expressing) to enrich the CT perspectives in the framework and show the importance of developing coding communities to co-create digital artifacts among learners. Overall, we highlighted that mathematics teachers should apply and create learning tasks that promote computational thinking to forge mathematical ideas and thinking.
Minimal change disease with papillary thyroid carcinoma: a report of two adult cases
Authors: Yin Juanjuan , Li Zexuan , Hao Zedong , Yu Zhuanzhuan , Yu Weimin , Yang Guang , Ren Xiaojun
Published: July 2023

Background

Minimal change disease (MCD), a pathological type of nephrotic syndrome (NS), can occur in patients with tumors. We report two adult cases of MCD associated with papillary thyroid carcinoma (PTC), known to be extremely rare in adults.

Case presentation

A 35-year-old female patient was simultaneously diagnosed with MCD and PTC. The MCD was effectively treated with thyroidectomy and prednisone.In addition, a 50-year-old male patient, who had been diagnosed with PTC three years prior, had MCD confirmed by renal biopsy. The patient achieved complete remission following treatment with tacrolimus and rituximab.

Conclusions

The present case report describes and discusses the diagnostic and treatment processes employed in these two patients. Clinicians need to be aware of the renal effects of treating patients with solid tumors.
BMI category-specific waist circumference thresholds based on cardiovascular disease outcomes and all-cause mortality: Tehran lipid and glucose study (TLGS)
Authors: Seyedhoseinpour Amirhosein , Barzin Maryam , Mahdavi Maryam , Valizadeh Majid , Azizi Fereidoun , Ghareh Sahar , Hosseinpanah Farhad
Published: July 2023

Background

Waist circumference (WC), a representative of abdominal visceral fat, is strongly associated with cardiovascular disease (CVD) and its outcomes. We aimed to define body mass index (BMI)-specific WC thresholds as predictors of CVD and all-cause mortality.

Methods

In this prospective cohort study in the context of the Tehran Lipid and Glucose Study (TLGS), a total of 3344 men and 4068 women were followed up for 18 years. Based on BMI, the participants were categorized into three groups: BMI < 25, 25 < BMI < 30, and BMI > 30. In each BMI category, sex-specific WC thresholds were estimated by the maximum value of Youden’s index to predict based on incident CVD events and all-cause mortality prediction.

Results

Overall 667 and 463 CVD events (the incidence rate of 3.1 to 4.5 in men and 1.1 to 2.6 in women per 1,000 person-years within BMI categories) and 438 and 302 mortalities (the incidence rate of 2.1 to 2.7 in men and 1.2 to 1.4 in women per 1,000 person-years within BMI categories) were recorded in men and women, respectively. WC thresholds in the BMI categories of < 25, 25–30, and BMI > 30 kg/m2 with regard to CVD events were 82, 95, and 103 cm in men and 82, 89, and 100 cm in women, and regarding all-cause mortality, the respective values were 88, 95, and 103 cm in men and 83, 90, and 99 cm among women.

Conclusion

BMI-specific WC thresholds observed here can help to better identify individuals at high risk of developing CVDs.
Medial augmentation plating of aseptic distal femoral nonunions
Authors: Lotzien Sebastian , Baron Darius , Rosteius Thomas , Cibura Charlotte , Ull Christopher , Schildhauer Thomas Armin , Geßmann Jan
Published: July 2023

Background

Distal femur nonunions are well-recognized contributors to persistent functional disability, with limited data regarding their treatment options. In the current study, we asked whether additional medial augmentation plating is a feasible treatment option for patients with aseptic distal femoral nonunion and intact lateral implants.

Methods

We conducted a single-center, retrospective study including 20 patients treated for aseptic distal femoral nonunion between 2002 and 2017. The treatment procedure included a medial approach to the distal femur, debridement of the nonunion site, bone grafting and medial augmentation plating utilizing a large-fragment titanium plate. Outcome measures were bone-related and functional results, measured by the Hospital for Special Surgery Knee Rating Scale (HSS) and the German Short Musculoskeletal Function Assessment questionnaire (SMFA-D).

Results

Eighteen of 20 nonunions showed osseous healing at 8.16 ± 5.23 (range: 3–21) months after augmentation plating. Regarding functional results, the mean HSS score was 74.17 ± 11.12 (range: 57–87). The mean SMFA-D functional index was 47.38 ± 16.78 (range 25.74–71.32) at the last follow-up. Index procedure-associated complications included two cases of persistent nonunion and one case of infection.

Conclusions

According to the assessed outcome measures, augmentation plating is a feasible treatment option, with a high proportion of patients achieving bony union and good functional outcomes and a few patients experiencing complications.
Can convertible metal-backed glenoid components replace cemented polyethylene glenoid components in anatomical total shoulder arthroplasty?
Authors: Kim Myung-Sun , Ahn Yeong-Seub , Lee Sun-Ho , Jeong Hyeon Jang , Kim Young Kyu , Oh Joo Han
Published: July 2023

Background

Anatomical total shoulder arthroplasty (aTSA) has been used to manage degenerative diseases such as primary osteoarthritis. An increase in the use of this procedure has led to several developments in humeral and glenoid components to improve patient outcomes. This study aimed to compare clinical and radiological outcomes of the newly-introduced convertible metal-backed glenoid components with cemented polyethylene glenoid components in aTSA, and to determine whether the new component would be comparable to a conventional one for reducing the burden of future revision or conversion surgeries.

Methods

Medical records of fifty patients who underwent aTSA with at least two years of follow-up were retrospectively reviewed. Eighteen patients received convertible metal-backed glenoid components with vitamin E1-coated liner (MB group), while thirty-two patients received conventional cemented polyethylene glenoid components (PE group). Pre- and postoperative clinical and radiological outcomes (acromion-greater tuberosity angle [AGA] and humeral lateral offset [LO]) at final follow-up were assessed. Radiolucent lines (RLLs) and loosening around the humeral and glenoid components were also evaluated.

Results

Clinical outcomes improved after surgery in both groups (all p < 0.001). The arc of rotation measured by AGA improved postoperatively in both groups (all p < 0.001), and AGA and LO were not different according to the type of glenoid components (all p > 0.05). Overall complication rates including RLLs of PE and MB groups were 43.8% (14/32) and 16.7% (3/18), respectively (p = 0.031). Although the PE group had more RLLs than did the MB group (p < 0.05), related symptoms and/or glenoid implant loosening were not observed in both groups. Subscapularis failure occurred in two patients in the PE group and in one in the MB group.

Conclusion

The convertible metal-backed glenoid implant with vitamin E1-coated liner may be a good alternative for considering the potential for an easier conversion to reverse total shoulder arthroplasty.
Dietary acid load and its interaction with CETP TaqB1 polymorphisms on lipid profile among patients with Type 2 diabetes mellitus
Authors: Abaj Faezeh , Esmaeily Zahra , Naeini Zeinab , Alvandi Ehsan , Rafiee Masoumeh , Koohdani Fariba
Published: July 2023

Objective

Gene-diet interaction plays a key role in the inter-individual differences in lipid abnormalities as a major risk factor for cardiovascular diseases (CVDs). Thus, we explored the interaction between CETP TaqB1 polymorphism with dietary acid load (DAL) on lipid profile among type 2 diabetes mellitus (T2DM).

Method

This cross-sectional study conducted on 220 Iranian patients with T2DM. Dietary acid load (PRAL and NEAP) was calculated via a validated food-frequency questionnaire (FFQ). The polymerase chain reaction (PCR) used for genotyping Taq1B polymorphism. Biochemical markers were measured by standard protocol. The interaction between CETP Taq1B polymorphism and DAL (PRAL and NEAP) on lipid profile was performed by a generalized linear regression model (GLM).

Results

The overall prevalence of rs708272 genotypes was 8.6%, 72.7% and 18.6% for B1B1, B1B2 and B2B2 genotype respectively. This study showed that people with the B1B1 genotype had greater LDL, TC, LDL/HDL, and TG when they consumed diets that scored higher on the NEAP and PRAL indexes than those with the B1B2 and B2B2 genotypes. Besides, carriers of the B1B1 allele who were in the highest tertile of NEAP, had lower HDL (P Interaction < 0.05).

Conclusions

In summary, the lipid profile might be improved in B1B1 homozygotes by less adherence to DAL indexes, however, the findings should be validated in high-quality interventional studies.