bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Developments in the Synthesis and Reactivity of Isoxazoles: Metal Catalysis and Beyond
Authors: Hu Feng , Szostak Michal
Published: August 2015

Isoxazoles are important five‐membered aromatic heterocycles in organic chemistry. Recently, many exciting advances in the synthesis and functionalization of isoxazoles have been reported. New transition metal‐catalyzed reactions have resulted in the development of attractive and highly efficient synthetic approaches to densely functionalized isoxazoles. Complete control of regioselectivity can be achieved on the basis of a judicious choice of metal catalyst and reaction partners using dipolar cycloaddition and cycloisomerization reactions, while more recent studies have focused on the site‐selective functionalization of isoxazoles via CH functionalization. New strategies for the use of isoxazoles as scaffolding templates in asymmetric synthesis have emerged, thus opening new prospects for the synthesis of enantioenriched motifs under the conditions that are orthogonal to other transformations. In this review, recent advances involving the synthesis and reactivity of isoxazoles are summarized. The review covers the period from January 2005 to June 2015.

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Fluorophore‐Conjugated Holliday Junctions for Generating Super‐Bright Antibodies and Antibody Fragments
Authors: Li Zeyang , Theile Christopher S. , Chen Guan‐Yu , Bilate Angelina M. , Duarte Joao N. , Avalos Ana M. , Fang Tao , Barberena Roberto , Sato Shuji , Ploegh Hidde L.
Published: August 2015

The site‐specific modification of proteins with fluorophores can render a protein fluorescent without compromising its function. To avoid self‐quenching from multiple fluorophores installed in close proximity, we used Holliday junctions to label proteins site‐specifically. Holliday junctions enable modification with multiple fluorophores at reasonably precise spacing. We designed a Holliday junction with three of its four arms modified with a fluorophore of choice and the remaining arm equipped with a dibenzocyclooctyne substituent to render it reactive with an azide‐modified fluorescent single‐domain antibody fragment or an intact immunoglobulin produced in a sortase‐catalyzed reaction. These fluorescent Holliday junctions improve fluorescence yields for both single‐domain and full‐sized antibodies without deleterious effects on antigen binding.
Identifizierung von Intermediaten der PR‐Toxin‐Biosynthese durch Penicillium roqueforti
Authors: Riclea Ramona , Dickschat Jeroen S.
Published: August 2015

Das Sesquiterpenoid 7‐epi‐Neopetason wurde über das Wieland‐Miescher‐Keton synthetisiert. Die Verbindung war identisch zu einem zuvor vorläufig identifizierten Bestandteil des Bouquets von Penicillium roqueforti. Fütterungsexperimente mit 13C‐markierten Isotopomeren von Mevalonolacton zeigten, dass die Oxidation an C12 und die Isomerisierung der C11‐C12‐ zur C7‐C11‐Doppelbindung unabhängig voneinander und nicht über ein C7‐C11‐C12‐Allylradikal in einem Schritt ablaufen. Fütterung von (11,12,13‐13C3)‐7‐epi‐Neopetason resultierte im Einbau der Isotopenmarkierung in PR‐Toxin, wodurch die Verbindung als biosynthetisches Intermediat etabliert wurde.
Transition‐Metal‐Catalyzed Hydrogen‐Transfer Annulations: Access to Heterocyclic Scaffolds
Authors: Nandakumar Avanashiappan , Midya Siba Prasad , Landge Vinod Gokulkrishna , Balaraman Ekambaram
Published: August 2015

The ability of hydrogen‐transfer transition‐metal catalysts, which enable increasingly rapid access to important structural scaffolds from simple starting materials, has led to a plethora of research efforts on the construction of heterocyclic scaffolds. Transition‐metal‐catalyzed hydrogen‐transfer annulations are environmentally benign and highly atom‐economical as they release of water and hydrogen as by‐product and utilize renewable feedstock alcohols as starting materials. Recent advances in this field with respect to the annulations of alcohols with various nucleophilic partners, thus leading to the formation of heterocyclic scaffolds, are highlighted herein.
Facile fabrication of g‐C3N4/MIL‐53(Al) composite with enhanced photocatalytic activities under visible‐light irradiation
Authors: Guo Di , Wen Rongying , Liu Minmin , Guo Hongxu , Chen Jianhua , Weng Wen
Published: August 2015

A novel visible‐light‐driven g‐C3N4/MIL‐53(Al) composite photocatalyst was successfully prepared using a facile stirring method at room temperature. The g‐C3N4/MIL‐53(Al) composites were characterized and their effects on the photocatalytic activities for rhodamine B degradation were investigated. The g‐C3N4(20 wt%)/MIL‐53(Al) photocatalyst displayed optimal photocatalytic degradation efficiency, which was about five times higher than the photocatalytic activity of pure g‐C3N4. The improved photocatalytic performance of the g‐C3N4/MIL‐53(Al) photocatalyst was predominantly attributed to the efficient separation of electron–hole pairs and the low charge‐transfer resistance. g‐C3N4/MIL‐53(Al) also exhibited excellent stability and reusability. A proposed mechanism for the enhanced photocatalytic activity is also discussed based on the experimental results. Copyright © 2015 John Wiley & Sons, Ltd.
Testing parameterization schemes for simulating depositional growth of ice crystal using Koenig and Takahashi parameters: a pre‐summer rainfall case study over Southern China
Authors: Li Xiaofan , Zhu Peijun , Zhai Guoqing , Liu Rui , Shen Xinyong , Huang Wei , Wang Donghai
Published: August 2015

In this study, the three (Hsie, Krueger and Zeng) schemes that parameterize depositional growth of ice crystal are tested using Koenig and Takahashi parameters in modeling China pre‐summer torrential rainfall event. The Krueger scheme with the Takahashi parameter produces the closest simulations to the observations because it increases cloud ice and snow in the upper troposphere. The increased ice hydrometeor enhances and suppresses infrared radiative cooling above and below 12 km, respectively. The suppressed infrared cooling reduces net condensation while the enhanced infrared cooling suppresses hydrometeor loss through the reduction in melting of ice hydrometeor.
A computer‐aided methodology for the optimization of electrostatic separation processes in recycling
Authors: Borrotti Matteo , Pievatolo Antonio , Critelli Ida , Degiorgi Andrea , Colledani Marcello
Published: August 2015

The rapid growth of technological products has led to an increasing volume of waste electrical and electronic equipments (WEEE), which could represent a valuable source of critical raw materials. However, current mechanical separation processes for recycling are typically poorly operated, making it impossible to modify the process parameters as a function of the materials under treatment, thus resulting in untapped separation potentials. Corona electrostatic separation (CES) is one of the most popular processes for separating fine metal and nonmetal particles derived from WEEE. In order to optimize the process operating conditions (i.e., variables) for a given multi‐material mixture under treatment, several technological and economical criteria should be jointly considered. This translates into a complex optimization problem that can be hardly solved by a purely experimental approach. As a result, practitioners tend to assign process parameters by few experiments based on a small material sample and to keep these parameters fixed during the process life‐cycle. The use of computer experiments for parameter optimization is a mostly unexplored area in this field. In this work, a computer‐aided approach is proposed to the problem of optimizing the operational parameters in CES processes. Three metamodels, developed starting from a multi‐body simulation model of the process physics, are presented and compared by means of a numerical and simulation study. Our approach proves to be an effective framework to optimize the CES process performance. Furthermore, by comparing the predicted response surfaces of the metamodels, additional insight into the process behavior over the operating region is obtained. Copyright © 2015 John Wiley & Sons, Ltd.
Dual lifetime referencing enables pH‐control for oxidoreductions in hydrogel‐stabilized biphasic reaction systems
Authors: Begemann Jens , Spiess Antje C.
Published: August 2015

pH‐shifts are a serious challenge in cofactor dependent biocatalytic oxidoreductions. Therefore, a pH control strategy was developed for reaction systems, where the pH value is not directly measurable. Such a reaction system is the biphasic aqueous‐organic reaction system, where the oxidoreduction of hydrophobic substrates in organic solvents is catalysed by hydrogel‐immobilized enzymes, and enzyme‐coupled cofactor regeneration is accomplished via formate dehydrogenase, leading to a pH‐shift. Dual lifetime referencing (DLR), a fluorescence spectroscopic method, was applied for online‐monitoring of the pH‐value within the immobilizates during the reaction, allowing for a controlled dosage of formic acid. It could be shown that by applying trisodium 8‐hydroxypyrene‐1, 3, 6‐trisulfonate as pH indicator and Ru(II) tris(4, 7‐diphenyl‐1, 10‐phenantroline) (Ru[dpp]) as a reference luminophore the control of the pH‐value in a macroscopic gel‐bead‐stabilized aqueous/organic two phase system in a range of pH 6.5 to 8.0 is possible. An experimental proof of concept could maintain a stable pH of 7.5 ± 0.15 during the reaction for at least 105 h. With these results, it could be shown that DLR is a powerful tool for pH‐control within reaction systems with no direct access for conventional pH‐measurement.
Syntheses and Characterizations of Two New Cadmium Complexes Based on Oxalate
Authors: Miao Ming‐San , Cheng Bo‐Lin , Liang Zhen , Yang Huai‐Xia , Meng Xiang‐Ru
Published: August 2015

Two new Cd(II) complexes, {[Cd(COO)2]2·2H2O}
n
(1) and {[CdCl(COO)2(Hbmi)]·H2O}
n
(2), were obtained through the reactions of oxalic acid (H2ox) with CdCl2
·2.5H2O in the presence of 1‐[(benzoimidazol‐yl)methyl]‐1H‐tetrazole (bmt) or 1‐[(benzoimidazol‐yl)methyl]‐1H‐imidazol (bmi). Single‐crystal X‐ray diffraction shows that complex 1 has a 3‐D structure with the topological notation of (48 · 62)(46 · 66 · 83)(42 · 84), in which the oxalate displays two kinds of coordination modes: formation of the layers (μ6‐ox) and linking the layers (μ4‐ox). In complex 2, oxalates bridge Cd(II) ions, forming a 1‐D chain, and (Hbmi)+ cations coordinate to the Cd(II) ions in monodentate mode and hang at two sides of the main chain. This indicates that subtle modification of the N‐donor ligands can result in complexes with different compositions and architectures. Moreover, their IR spectra, PXRD (powder X‐ray diffraction) patterns, thermogravimetric analyses, and fluorescence properties are also investigated.
Preparation of core–shell structure Fe3O4@SiO2 superparamagnetic microspheres immoblized with iminodiacetic acid as immobilized metal ion affinity adsorbents for His‐tag protein purification
Authors: Ni Qian , Chen Bing , Dong Shaohua , Tian Lei , Bai Quan
Published: August 2015

The core–shell structure Fe3O4/SiO2 magnetic microspheres were prepared by a sol–gel method, and immobiled with iminodiacetic acid (IDA) as metal ion affinity ligands for protein adsorption. The size, morphology, magnetic properties and surface modification of magnetic silica nanospheres were characterized by various modern analytical instruments. It was shown that the magnetic silica nanospheres exhibited superparamagnetism with saturation magnetization values of up to 58.1 emu/g. Three divalent metal ions, Cu2+, Ni2+ and Zn2+, were chelated on the Fe3O4@SiO2–IDA magnetic microspheres to adsorb lysozyme. The results indicated that Ni2+‐chelating magnetic microspheres had the maximum adsorption capacity for lysozyme of 51.0 mg/g, adsorption equilibrium could be achieved within 60 min and the adsorbed protein could be easily eluted. Furthermore, the synthesized Fe3O4@SiO2–IDA–Ni2+ magnetic microspheres were successfully applied for selective enrichment lysozyme from egg white and His‐tag recombinant Homer 1a from the inclusion extraction expressed in Escherichia coli. The result indicated that the magnetic microspheres showed unique characteristics of high selective separation behavior of protein mixture, low nonspecific adsorption, and easy handling. This demonstrates that the magnetic silica microspheres can be used efficiently in protein separation or purification and show great potential in the pretreatment of the biological sample. Copyright © 2015 John Wiley & Sons, Ltd.
Hybrid transatrial stent insertion for left atrial decompression in hypoplastic left heart syndrome with intact atrial septum
Authors: Hermuzi Antony , McBrien Angela , De Rita Fabrizio , McCheyne Alan , Griselli Massimo , O'Sullivan John J. , Hasan Asif , Crossland David S.
Published: August 2015

Objectives

To describe a novel strategy for the management of infants with hypoplastic left heart syndrome (HLHS) and intact atrial septum. Antenatally diagnosed infants are delivered in cardiac theatre and immediate left atrial decompression (LAD) using hybrid transatrial stent insertion (HTSI) via sternotomy is carried out.

Background

HLHS with intact atrial septum is a condition incompatible with life following placental separation. Despite a number of reported strategies the survival of these infants remains much worse than those born with an adequate atrial communication. Immediate postnatal LAD is mandatory to allow consideration of active treatment.

Methods

Single institution retrospective review of intention to carry out HTSI for LAD in infants with an antenatal diagnosis of HLHS intact atrial septum.

Results

Two patients were delivered by planned caesarean section and transferred immediately to the prepared team in the adjacent cardiothoracic theatre. Birth weights were 3.2 Kg and 2.96 Kg. Clinical condition was poor with mean arterial PaO2 2.8kPa intubated with 100% inspired oxygen. HTSI was performed using premounted 7 × 17 mm stents (Visi‐Pro™, eV3 Endovascular, Plymouth, MN). Mean arterial PaO2 improved to 6.2 kPa. Mean time from surgical incision to LAD was 26 min. Bilateral pulmonary artery bands (BPAB) were then placed. No procedural complications occurred and both patients underwent subsequent surgical stage 1 Norwood at 6 and 10 days.

Conclusions

In this high‐risk anatomical substrate, careful planning from accurate fetal diagnosis underpins the success of initial management. This early experience suggests that HTSI offers rapid and successful postnatal LAD with no procedural morbidity facilitating successful subsequent palliation. © 2015 Wiley Periodicals, Inc.
Valve‐in‐valve using an Edwards Sapien XT into a JenaValve in a patient with a low originating left coronary artery and a heavily calcified aorta
Authors: Fujita Buntaro , Scholtz Smita , Ensminger Stephan
Published: August 2015

Coronary obstruction during transcatheter aortic valve implantation is a potentially life‐threatening complication. Most of the widely used transcatheter heart valves require a certain distance between the basal aortic annular plane and the origins of the coronary arteries. We report the case of a successful valve‐in‐valve procedure with an Edwards SAPIEN XT valve into a JenaValve as a bail‐out procedure in a patient with a low originating left coronary artery and a heavily calcified aorta. © 2015 Wiley Periodicals, Inc.
Comparison of acute kidney injury classifications in patients undergoing transcatheter aortic valve implantation: Predictors and long‐term outcomes
Authors: Koifman Edward , Segev Amit , Fefer Paul , Barbash Israel , Sabbag Avi , Medvedovsky Diego , Spiegelstein Dan , Hamdan Ashraf , Hay Ilan , Raanani Ehud , Goldenberg Ilan , Guetta Victor
Published: August 2015

Background

Acute kidney injury (AKI) was demonstrated to adversely affect outcome in patients undergoing transcatheter aortic valve implantation (TAVI). We compared predictors for AKI and associated outcomes according to various definitions among patients undergoing TAVI in a tertiary medical center.

Methods

Two‐hundred and seventeen TAVI patients were evaluated for the occurrence of AKI according to Kidney Disease Improving Global Outcomes (KDIGO)/Valve Academic Research Consortium (VARC‐2) and Risk Injury Failure Loss End‐Stage (RIFLE) definitions. Multivariate analysis was conducted to assess predictors of AKI. Cox hazard ratio was used to evaluate long‐term mortality in this patient population.

Results

AKI occurred in 23 and 21% of patients (n = 49, n = 46) according to KDIGO/VARC‐2 and RIFLE definitions, respectively, with an approximate 10% of disagreement between both systems. Predictors of AKI according to KDIGO/VARC‐2 were chronic obstructive pulmonary disease (COPD; OR = 2.66, P = 0.01), PVD (OR = 3.45, P = 0.02) and a lower baseline eGFR (OR = 1.03 per 1 mL/min/1.73 m2 decrease, P = 0.02). While BMI (OR = 1.12, P = 0.01), prior ischemic heart disease (OR = 2.35, P = 0.04) and COPD (OR = 2.18, P = 0.04) were associated with AKI as defined by the RIFLE definition. AKI defined by either classification was independently associated with long‐term mortality (HR = 1.63, for the KDIGO/VARC‐2 definition and HR = 1.60 for RIFLE definition, P = 0.04 for both models), with borderline superiority of the KDIGO/VARC‐2 classification.

Conclusions

Different clinical characteristics predict the occurrence of AKI after TAVI when RIFLE and KDIGO/VARC‐2 classifications are used. Both classification systems of AKI identify patients with increased risk for long‐term mortality, with superiority of the KDIGO/VARC‐2 definition, which should be used for AKI grading. © 2015 Wiley Periodicals, Inc.
Optimal threshold of postintervention minimum stent area to predict in‐stent restenosis in small coronary arteries: An optical coherence tomography analysis
Authors: Matsuo Yoshiki , Kubo Takashi , Aoki Hiroshi , Satogami Keisuke , Ino Yasushi , Kitabata Hironori , Taruya Akira , Nishiguchi Tsuyoshi , Teraguchi Ikuko , Shimamura Kunihiro , Shiono Yasutsugu , Orii Makoto , Yamano Takashi , Tanimoto Takashi , Yamaguchi Tomoyuki , Hirata Kumiko , Tanaka Atsushi , Akasaka Takashi
Published: August 2015

Objectives

The aim of this study was to determine the best threshold of postintervention minimum stent area (MSA) assessed by optical coherence tomography (OCT) to predict long‐term in‐stent restenosis (ISR) for 2.5 mm‐diameter everolimus‐eluting stents (EES).

Background

Percutaneous coronary intervention (PCI) for small coronary arteries remains challenging. Stent underexpansion is a strong predictor of late ISR.

Methods

We performed a retrospective analysis of 69 lesions in 69 patients undergoing PCI with 2.5 mm‐diameter stents using OCT for the assessment of postintervention MSA and subsequent 9‐month angiographic follow‐up.

Results

The rates of angiographic ISR and target lesion revascularization were 7.2% and 1.4%. The postintervention OCT‐MSA of EES < 3.5 mm2 for predicting ISR yielded a sensitivity of 80%, specificity of 71%, positive predictive value of 18%, and negative predictive value of 98%. There was a marginally significant trend between increasing MSA quartiles and decreasing ISR rate (P for trend = 0.07).

Conclusions

Postintervention OCT‐MSA of 3.5 mm2 best predicted 9‐month ISR following PCI with 2.5‐mm‐diameter EES. Further large, prospective, observational studies are warranted that validate this result. © 2015 Wiley Periodicals, Inc.
Aluminum Redistribution during the Preparation of Hierarchical Zeolites by Desilication
Authors: Mitchell Sharon , Milina Maria , Verel René , Hernández‐Rodríguez Manuel , Pinar Ana B. , McCusker Lynne B. , Pérez‐Ramírez Javier
Published: August 2015

A literature survey reveals a prominent reduction in the concentration of Brønsted acid sites in hierarchically organized zeolites with increasing mesoporous or external surface area independent of the framework type or synthesis route; this suggests a common fundamental explanation. To determine the cause, nature, and impact of the underlying changes in aluminum speciation, this study combines a multitechnique analysis that integrates basic characterization, a detailed synchrotron XRD and multiple‐quantum NMR spectroscopy assessment, and catalytic tests to correlate evolution of the properties with performance during successive steps in the preparation of hierarchical MFI‐type zeolites by desilication. The findings, subsequently generalized to FAU‐ and BEA‐type materials, identify the crucial impact of calcination on the protonic form, which is an integral step in the synthesis and regeneration of zeolite catalysts; on aluminum coordination; and the associated acidity trends.
Combining Crystallography and Hydrogen–Deuterium Exchange to Study Galectin–Ligand Complexes
Authors: Ruiz Federico M. , Gilles Ulrich , Lindner Ingo , André Sabine , Romero Antonio , Reusch Dietmar , Gabius Hans‐Joachim
Published: August 2015

The physiological significance arising from translating information stored in glycans into cellular effects explains the interest in structurally defining lectin–carbohydrate recognition. The relatively small set of adhesion/growth‐regulatory galectins in chicken makes this system attractive to study the origins of specificity and divergence. Cell binding by using glycosylation mutants reveals binding of the N‐terminal domain of chicken galectin‐8 (CG‐8N) to α‐2,3‐sialylated and galactose‐terminated glycan chains. Cocrystals with lactose and its 3′‐sialylated derivative disclose Arg58 as a key contact for the carboxylic acid and differences in loop lengths to the three homodimeric chicken galectins. Monitoring hydrogen–deuterium exchange by mass spectrometry revealed an effective reduction of deuteration after ligand binding within the contact area. In addition, evidence for changes in solvent accessibility of amide protons beyond this site was obtained. Their detection, which highlights the sensor capacity of this technique, encourages systematic studies on galectins and beyond.
Efficient Synthesis of Conformationally Restricted Apoptosis Inhibitors Bearing a Triazole Moiety
Authors: Corredor Miriam , Garrido Maria , Bujons Jordi , Orzáez Mar , Pérez‐Payá Enrique , Alfonso Ignacio , Messeguer Angel
Published: August 2015

Apoptosis is a biological process relevant to different human diseases that is regulated through protein–protein interactions and complex formation. Peptidomimetic compounds based on linear peptoids and cyclic analogues with different ring sizes have been previously reported as potent apoptotic inhibitors. Among them, the presence of cis/trans conformers of an exocyclic tertiary amide bond in slow exchange has been characterized. This information encouraged us to perform an isosteric replacement of the amide bond by a 1,2,3‐triazole moiety, in which different substitution patterns would mimic different amide rotamers. The syntheses of these restricted analogues have been carried out through an Ugi multicomponent reaction followed by an intramolecular cyclization. The unexpected formation of a β‐lactam scaffold prompted us to study the course of the intramolecular cyclization of the Ugi adducts. In order to modulate this cyclization, a small library of compounds bearing both heterocyclic scaffolds has been synthesized and their activities as apoptosis inhibitors have been evaluated.
ChemInform Abstract: Crystal Structures of Hydrazinium(II) Salts of [SbF6]‐ and [Sb2F11]‐.
Authors: Mazej Zoran , Goreshnik Evgeny A.
Published: August 2015

Compounds (III) (yield given in g) and (IV) are synthesized in anhydrous HF and their crystal structures are determined by single crystal XRD.
ChemInform Abstract: Phase Equilibria in the Tl—TlI—Se System and Thermodynamic Properties of the Ternary Phases.
Authors: Babanly Dunya M. , Amiraslanov Imameddin R. , Shevelkov Andrei V. , Tagiyev Dilgam B.
Published: August 2015

Several polythermal sections, the isothermal section at 300 K, and the projection of the liquidus surface of the Tl‐TlI‐Se system are constructed using DTA, XRD, and EMF methods.
ChemInform Abstract: Low‐Cost Orthorhombic Na[FeTi]O4 (x = 1 and 4/3) Compounds as Anode Materials for Sodium‐Ion Batteries.
Authors: Li Jie , et al.
Published: August 2015

Nax[FeTi]O4 (x = 1 and 4/3) anode materials are prepared by calcining stoichiometric amounts of Na2CO3, FeC2O4, and TiO2 in air (900 °C, 12 h).
ChemInform Abstract: Lithium Insertion into Li2MoO4: Reversible Formation of (Li3Mo)O4 with a Disordered Rock‐Salt Structure.
Authors: Mikhailova D. , Voss A. , Oswald S. , Tsirlin A. A. , Schmidt M. , Senyshyn A. , Eckert J. , Ehrenberg H.
Published: August 2015

Cubic Li3‐xMoO4 is obtained by reaction of Li2MoO4 with BuLi in hexane solution (double or triple excess of BuLi).
ChemInform Abstract: Twisted Kelvin Cells and Truncated Octahedral Cages in the Crystal Structures of Unconventional Clathrates, AM2P4 (A: Sr, Ba; M: Cu, Ni).
Authors: Dolyniuk Juli‐Anna , Wang Jian , Lee Kathleen , Kovnir Kirill
Published: August 2015

AM2P4 (A: Ba, Sr; M: Ni, Cu) are prepared by solid state reaction of the elements in stoichiometric amounts (glassy‐C crucible in evacuated silica tubes, 1123 K, 140 h).
ChemInform Abstract: Asymmetric Dihydroxylation of Esters and Amides of Methacrylic, Tiglic, and Angelic Acid: No Exception to the Sharpless Mnemonic!
Authors: Weber Fabian , Brueckner Reinhard
Published: August 2015

Derivatives of methacrylic, tiglic, and angelic acid are subjected to asymmetric dihydroxylation by a modified Sharpless asymmetric dihydroxylation protocol.
ChemInform Abstract: Pd/Mannose Promoted Tandem Cross Coupling‐Nitro Reduction: Expedient Synthesis of Aminobiphenyls and Aminostilbenes.
Authors: Rohilla Sandeep , Pant Pradeep , Jain Nidhi
Published: August 2015

The dual role of D‐mannose as ligand for the Pd‐catalyzed cross‐coupling and as hydrogen source for the nitro reduction is demonstrated.
ChemInform Abstract: Bis(acetylacetonato)copper(II) Catalyzed Oxidative Cross‐Dehydrogenative Coupling (CDC) for the Synthesis of α‐Acyloxy Ethers Through Direct Activation of α‐C(sp3)—H Bond of Cyclic Ether.
Authors: Talukdar Dhrubajyoti , Borah Suchibrata , Chaudhuri Mihir K.
Published: August 2015

A practical and efficient method for the construction of C—O bond via cross‐dehydrogenative coupling reaction of carboxylic acid and cyclic ethers under atmospheric condition is reported.
ChemInform Abstract: Facile Synthesis of N‐Acylbenzotriazoles from Carboxylic Acids Mediated by 2,4,6‐Trichloro‐1,3,5‐triazine and Triethylamine.
Authors: Wet‐osot Sirawit , Duangkamol Chuthamat , Pattarawarapan Mookda , Phakhodee Wong
Published: August 2015

Acylbenzotriazoles are prepared from carboxylic acids and benzotriazole using trichlorotriazine in combination with Et3N as a carboxylic acid activator.
ChemInform Abstract: Synthesis of Acyclic Polycarbonyl Compounds via Ozonolysis of Cyclohexa‐1,4‐dienes.
Authors: Kuttner Julian R. , Hilt Gerhard
Published: August 2015

The acyclic polycarbonyl compounds can be synthesized by ozonolysis followed by the reduction using phosphine‐ or phosphite‐type reductants.
ChemInform Abstract: Ni‐Catalyzed Highly Chemo‐, Regio‐, and Enantioselective Decarboxylative Aldol Reaction of β,γ‐Unsaturated α‐Ketoesters with β‐Ketoacids.
Authors: Wei Ai‐Jia , Nie Jing , Zheng Yan , Ma Jun‐An
Published: August 2015

A novel Ni‐catalyzed decarboxylative aldol reaction of β,γ‐saturated α‐ketoesters with β‐ketoacids is reported.
ChemInform Abstract: Copper‐Catalyzed Dicyanation of N,N‐Disubstituted Formamide.
Authors: Mou Xue‐Qing , Xu Li , Wang Shao‐Hua , Yang Chao
Published: August 2015

The novel method allows the synthesis of dialkylamino substituted malononitriles in low to good yields.
ChemInform Abstract: Efficient and Versatile Synthesis of 5‐O‐Acylquinic Acids with a Direct Esterification Using a P‐Methoxybenzyl Quinate as a Key Intermediate.
Authors: Oyama Kin‐ichi , Watanabe Noriyuki , Yamada Tomomi , Suzuki Masako , Sekiguchi Yukiko , Kondo Tadao , Yoshida Kumi
Published: August 2015

The esterification of the sterically hindered 5‐OH group of p‐methoxybenzyl quinate (I) obtained in five steps from commercially available (‐)‐quinic acid is presented.
ChemInform Abstract: One‐Pot Synthesis of Unsymmetrical Squaramides.
Authors: Alegre‐Requena Juan V. , Marques‐Lopez Eugenia , Herrera Raquel P.
Published: August 2015

A straightforward procedure for the first one‐pot synthesis of unsymmetrical squaramides is given.
ChemInform Abstract: Tandem Gold/Silver‐Catalyzed Cycloaddition/Hydroarylation of 7‐Aryl‐1,6‐enynes to Form 6,6‐Diarylbicyclo[3.2.0]heptanes.
Authors: Robertson Bradley D. , Brooner Rachel E. M. , Widenhoefer Ross A.
Published: August 2015

The tandem cycloaddition/hydroarylation of title compounds (I), (IV), and (V) with electron‐rich arenes in the presence of a Au/Ag catalytic system is reported.
ChemInform Abstract: Solvent‐Free Synthesis of Novel Styrenesulfonamide Derivatives and Evaluation of Their Antibacterial Activity.
Authors: Maghsoodi Narjes Khaton , Khazaeli Tooba , Massah Ahmad Reza
Published: August 2015

Antibacterial activity is observed for new styrenesulfonamides (III) against Gram‐positive Staphylococcus aureus, with compounds (IIIc,d) being the most effective ones.
ChemInform Abstract: Bismuth(III) Bromide‐Catalyzed Substitution of Benzyl Alcohols with Arylsulfonylmethyl Isocyanides: An Unexpected Access to Sulfinates.
Authors: Li Hui‐Jing , Wang Rui , Gao Jing , Wang Yuan‐Yuan , Luo Dong‐Hui , Wu Yan‐Chao
Published: August 2015

An unexpected reversal of reactivity is observed to give sulfinates highly selectively instead of the usual sulfones.
ChemInform Abstract: Synthesis of Sulfones via a Reaction of Aryldiazonium Tetrafluoroborates, Sulfur Dioxide, and Aryliodoniums
Authors: Liu Xia , Li Wei , Zheng Danqing , Fan Xiaona , Wu Jie
Published: August 2015

17 examples
ChemInform Abstract: Lanthanide(III)‐Bis(cyclopropylethinylamidinates): Synthesis, Structure, and Catalytic Activity.
Authors: Sroor Farid M. , Hrib Cristian G. , Hilfert Liane , Jones Peter G. , Edelmann Frank T.
Published: August 2015

It is demonstrated, that a bis‐neodym complex BND efficiently catalyzes the addition of primary aromatic amines to carbodiimides producing N‐arylguanidines in high yields.
ChemInform Abstract: Palladium‐Catalyzed Oxidative Heck Coupling of Cyclic Enones with Simple Arenes by C—H Activation.
Authors: Chung Leung Gulice Yiu , Juwaini Nur Asyikin Binte , Seayad Jayasree
Published: August 2015

The simple catalyst system allows the coupling of cyclic enones with arenes using molecular oxygen as the oxidant.
ChemInform Abstract: Diastereoselective Carbonyl Allylation with Simple Olefins Enabled by Palladium Complex‐Catalyzed C—H Oxidative Borylation.
Authors: Tao Zhong‐Lin , Li Xing‐Han , Han Zhi‐Yong , Gong Liu‐Zhu
Published: August 2015

The title allylation is a sequential process consisting a Pd‐catalyzed oxidative allylic C—H borylation and a phosphoric acid‐accelerated allylboration of aldehydes and isatins.
ChemInform Abstract: Calcium‐Catalyzed Carboarylation of Alkynes.
Authors: Fu Liang , Niggemann Meike
Published: August 2015

A series of dihydronaphthalenes is synthesized by reaction of various arylalkyl tethered alkynes with secondary alcohols in the presence of Ca(NTf2)2 and Bu4NPF6 as catalysts is developed.
ChemInform Abstract: Triphenylphosphine—N‐Bromosuccinimide Mediated Chemoselective Cyclodehydration of Diols.
Authors: Zhao Shuo , Wu You , Sun Qi , Cheng Tie‐Ming , Li Run‐Tao
Published: August 2015

1,4‐Diols [e.g. (I)] undergo cyclodehydration and give tetrahydrofurans [e.g. (II)] when 1 equiv.
ChemInform Abstract: Platinum‐Catalyzed Domino Reaction with Benziodoxole Reagents for Accessing Benzene‐Alkynylated Indoles.
Authors: Li Yifan , Waser Jerome
Published: August 2015

A novel domino cyclization process for the synthesis of C5‐ or C6‐alkynylated indoles is developed using the reaction of C2‐ or C3‐substituted pyrroles with a hypervalent iodine alkynylating agent.
ChemInform Abstract: Design of Pyrazolo‐pyrrolo‐pyrazines and Pyrazolo‐pyrrolo‐diazepines via AuCl3‐Catalyzed and NaH‐Supported Cyclization of N‐Propargyl Pyrazoles.
Authors: Basceken Sinan , Balci Metin
Published: August 2015

Key features of this new method include the synthesis of pyrrole‐derived α,β‐alkynyl ketones, the introduction of various substituents into the alkyne functionality by Sonogashira cross‐coupling, the synthesis of pyrazole units by reaction of α,β‐alkynyl compounds with hydrazine monohydrate, a gold‐catalyzed cyclization of pyrazoles with alkyne units, and subsequent cyclization with NaH.
ChemInform Abstract: Cobalt Manganese Oxide Nanoparticles as Recyclable Catalyst for Efficient Synthesis of 2‐Aryl‐1‐arylmethyl‐1H‐1,3‐benzimidazoles under Solvent‐Free Conditions.
Authors: Ahmadian Hossein , Veisi Hojat , Karami Changiz , Sedrpoushan Alireza , Nouri Maryam , Jamshidi Fariba , Alavioon Iman
Published: August 2015

The newly synthesized nanocatalyst is shown to be a highly efficient green catalyst for the synthesis of 2‐aryl‐1‐arylmethyl‐1H‐1,3‐benzimidazoles (III) under solvent‐free conditions.
ChemInform Abstract: 2‐Phenyl‐2‐(4‐phenyl‐1H‐1,2,3‐triazol‐1‐yl)ethanol as an Efficient and Versatile Auxiliary Ligand in Copper(II)‐Catalyzed Buchwald—Hartwig and Sharpless—Meldal C—N Bond‐Forming Reactions.
Authors: Sharghi Hashem , Shiri Pezhman
Published: August 2015

A variety of N‐aryl compounds and 1,4‐disubstituted triazoles can be synthesized from the title reactions.
ChemInform Abstract: One‐Pot Catalyst Free Synthesis of Novel Kojic Acid Tagged 2‐Aryl/Alkyl Substituted‐4H‐chromenes and Evaluation of Their Antimicrobial and anti‐Biofilm Activities.
Authors: Bingi Chiranjeevi , Emmadi Narender Reddy , Chennapuram Madhu , Poornachandra Y. , Kumar C. Ganesh , Nanubolu Jagadeesh Babu , Atmakur Krishnaiah
Published: August 2015

Various of the novel title compounds (III) (16 examples) display potent antimicrobial activities, e.g. (IIIa‐c), (IIIg), (IIIi), as well as very good anti‐biofilm activity.
ChemInform Abstract: Trio Catalysis Merging Enamine, Broensted Acid, and Metal Lewis Acid Catalysis: Asymmetric Three‐Component Aza‐Diels—Alder Reaction of Substituted Cinnamaldehydes, Cyclic Ketones, and Arylamines.
Authors: Deng Yongming , Kumar Siddhartha , Wheeler Kraig , Wang Hong
Published: August 2015

A trio catalyst system composed of arylamine, BINOL‐derived phosphoric acid, and Y(OTf)3, enables the combination of enamine catalysis with both hard metal Lewis acid catalysis and Broensted acid catalysis for the first time.
ChemInform Abstract: One‐Pot Multicomponent Synthesis of Novel Substituted Imidazo[1,2‐a]pyridine Incorporated Thiazolyl Coumarins and Their Antimicrobial Activity.
Authors: Gali Rajitha , Banothu Janardhan , Bavantula Rajitha
Published: August 2015

All the formed title compounds (IV) (20 examples) display moderate antibacterial activity, but none of them show any antifungal activities.
ChemInform Abstract: Metal Free Direct Formation of Various Substituted Pyrido[2′,1′:2,3]imidazo[4,5‐c]isoquinolin‐5‐amines and Their Further Functionalization.
Authors: Tber Z. , Hiebel M.‐A. , Allouchi H. , El Hakmaoui A. , Akssira M. , Guillaumet G. , Berteina‐Raboin S.
Published: August 2015

The title compounds (V) and related fused system (X) are obtained by Groebke—Blackburn—Bienayme multicomponent reactions combined with an N‐deprotection and a spontaneous final cyclization step.
ChemInform Abstract: Facile and Efficient One‐Pot Synthesis of Highly Functionalized 1,2,3,5‐Tetrahydroimidazo[1,2‐a]pyrimidines.
Authors: Vojdani Zeinab , Mohebat Razieh
Published: August 2015

Title compounds (IV) are efficiently synthesized without any activation in excellent yields at room temperature.
ChemInform Abstract: Zn(II) Triflate‐Catalyzed N‐Glycosylation: Synthesis of Sulfonamide and Amide Functionalized 2,3‐Unsaturated Glycosides.
Authors: Reddy Thurpu Raghavender , Battina Suresh Kumar , Kashyap Sudhir
Published: August 2015

A highly efficient and mild method for the synthesis of glycosyl sulfonamides and glycosyl amides from glycal is presented using Zn(OTf)2 as an economical and environmentally friendly catalyst.
ChemInform Abstract: Nucleoside Azide—Alkyne Cycloaddition Reactions under Solvothermal Conditions or Using Copper Vials in a Ball Mill.
Authors: Vyle Joseph S. , et al.
Published: August 2015

Solution‐phase conditions and vibration ball milling to effect the preparation of triazole‐linked photoswitchable nucleosides like (III) are compared.
ChemInform Abstract: Flavones from the Bark of Lindera caudata and Their anti‐Tobacco Mosaic Virus Activity
Authors: Yang Yu‐Chun , Qin Ying , Wu Xian‐Xue , Xia Cong‐Fang , Meng Yan‐Lin , Zhou Bin , Ye Yan‐Qing , Gao Xue‐Mei , Li Yin‐Ke , Hu Qiu‐Fen
Published: August 2015

isolation and structure elucidation of two new flavones (Ia,b)
ChemInform Abstract: Palladium‐Mediated Organofluorine Chemistry
Authors: Albeniz Ana C. , Casares Juan A.
Published: August 2015

Review: 361 refs.
ChemInform Abstract: Catalytic Transformation of Aldehydes with Nickel Complexes Through η2 Coordination and Oxidative Cyclization
Authors: Hoshimoto Yoichi , Ohashi Masato , Ogoshi Sensuke
Published: August 2015

Review: 85 refs.
ChemInform Abstract: Self‐Assemblies of Amphiphilic Homopolymers: Synthesis, Morphology Studies and Biomedical Applications
Authors: Zhang Jin , Liu Kelan , Muellen Klaus , Yin Meizhen
Published: August 2015

Review: 119 refs.
ChemInform Abstract: The Forgotten Carbonyl Reaction: Chloroacetylation and Bromoacetylation of Carbonyl Compounds
Authors: Neuenschwander Markus
Published: August 2015

Review: 27 refs.
ChemInform Abstract: Peptide Nanostructures with π‐Ways: Photophysical Consequences of Peptide/π‐Electron Molecular Self‐Assembly
Authors: Tovar John D.
Published: August 2015

Review: 26 refs.
ChemInform Abstract: Electron Transport Mediated by Peptides Immobilized on Surfaces
Authors: Juhaniewicz Joanna , Pawlowski Jan , Sek Slawomir
Published: August 2015

Review: 141 refs.
ChemInform Abstract: The Impervious Route to Peptide‐Based Dye‐Sensitized Solar Cells
Authors: Gatto Emanuela , Venanzi Mariano
Published: August 2015

Review: [54 refs.
ChemInform Abstract: Perspectives on the Replacement of Harmful Organic Solvents in Analytical Methodologies: A Framework Toward the Implementation of a Generation of Eco‐Friendly Alternatives
Authors: Pena‐Pereira Francisco , Kloskowski Adam , Namiesnik Jacek
Published: August 2015

Review: 183 refs.
Mechanofluorochromism of 1‐Alkanoylaminopyrenes
Authors: Nagata Eisuke , Takeuchi Shugo , Nakanishi Takayuki , Hasegawa Yasuchika , Mawatari Yasuteru , Nakano Hideyuki
Published: August 2015

To create a new series of mechanofluorochromic materials and to elucidate the mechanism of the phenomenon of mechanofluorochromism, 1‐alkanoylaminopyrenes including 1‐acetylaminopyrene (AAPy), 1‐octanoylaminopyrene (OAPy), and 1‐stearoylaminopyren (SAPy) were prepared. It was found that these materials exhibited mechanofluorochromism with emission colors in the crystalline samples changing reversibly from bluish purple to yellowish green, which could be induced by mechanical grinding. X‐ray crystal structure analysis, electronic absorption, and fluorescence spectroscopies, as well as fluorescence lifetime analysis and powder X‐ray diffraction analysis of AAPy suggested that the present mechanofluorochromism was caused by developing crystal defects through grinding. Intermolecular hydrogen bonds were suggested to play an important role in the occurrence of mechanofluorochromism, suppressing the face‐to‐face overlapping of pyrene moieties to form excimers in the pristine crystal.
Chiral Gold Nanoparticles Decorated with Pseudopeptides
Authors: Fanelli Rossana , Milli Lorenzo , Cornia Andrea , Moretto Alessandro , Castellucci Nicola , Zanna Nicola , Malachin Giulia , Tavano Regina , Tomasini Claudia
Published: August 2015

Peptide‐functionalized gold nanoparticles are supramolecular systems that can mimic natural proteins or DNA. In this work, we describe the preparation, the analysis, and the biological evaluation of gold nanoparticles linked to pseudopeptide foldamers containing one to eight L‐Ala‐D‐Oxd (Ala = alanine; Oxd = 4‐carboxy‐5‐methyloxazolidin‐2‐one) residues. The nanoparticles become increasingly organized as the number of such moieties increases. Moreover, from the analysis of chiroptical signals we find that the chirality of the gold surface becomes more evident with decreasing foldamer length. Finally, these systems display no cytotoxicity towards HeLa cells and are good candidates to promote drug delivery once equipped with biologically active moieties.
Factors affecting treatment of TFT‐LCD wastewater by fenton and electro‐fenton processes
Authors: Methatham Thanakorn , Bellotindos Luzvisminda M. , Chen Ten‐En , Lu Ming‐Chun
Published: August 2015

The TFT‐LCD screen (thin film transistor liquid crystal display) industry has been growing rapidly in Taiwan in recent years. The wastewater from this industry contains many non‐biodegradable pollutants and high strength nitrogen and sulfur containing compounds which are difficult to degrade. Fenton and electro‐Fenton with double‐cathode processes were used to treat the high COD content of real TFT‐LCD wastewater which cannot be removed by conventional processes. The effect of operating parameters such as pH, Fe2+, H2O2 concentration and electrical current on COD removal were determined. The electro‐Fenton process rapidly degraded the TFT‐LCD wastewater in the first 20 minutes while in the Fenton process, the rapid degradation occurred in the first 60 min. This showed that electro‐Fenton process could degrade the TFT‐LCD wastewater faster than the Fenton process. The highest COD removal efficiency was found to be 100% at 120 min at pH = 4, [Fe2+] = 3.5 mM, [H2O2] = 285 mM and 1.5 A of electrical current of electro‐Fenton process. © 2015 American Institute of Chemical Engineers Environ Prog, 35: 368–373, 2016
Metastatic lymph node status in the central compartment of papillary thyroid carcinoma: A prognostic factor of locoregional recurrence
Authors: Park Young Min , Wang Soo‐Geun , Lee Jin‐Choon , Shin Dong Hoon , Kim In‐Ju , Son Seok‐Man , Mun Mijin , Lee Byung‐Joo
Published: August 2015

Background

The purpose of this study was to present our focus on the lymph node status in the central compartment and evaluate the relevant factors and disease recurrence.

Methods

Between January 2004 and December 2009, 1040 patients were diagnosed with papillary thyroid carcinoma (PTC) and underwent surgery.

Results

The number of metastatic lymph nodes was a significant predictor for recurrence conferring a hazard ratio of 1.36 (confidence interval = 1.103–1.680; p = .004). The receiver operating characteristic (ROC) curve was calculated to determine the cutoff number of lymph nodes that predicted recurrence with the highest sensitivity and specificity (area under the ROC curve, 0.794; SE, 0.077; p = .001). The sensitivity/specificity of >3 metastatic lymph nodes for predicting recurrence was 63.6%/77.0%, respectively.

Conclusion

The number of metastatic lymph nodes in the central compartment was a statistical significant predictive factor associated with disease recurrence. Further study is required to confirm the relationship between the number of lymph nodes and disease recurrence. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1172–E1176, 2016
BRAF V600E mutation: Differential impact on central lymph node metastasis by tumor size in papillary thyroid carcinoma
Authors: Kim Seo Ki , Lee Jun Ho , Woo Jung‐Woo , Park Inhye , Choe Jun‐Ho , Kim Jung‐Han , Kim Jee Soo
Published: August 2015

Background

The necessity of prophylactic central neck dissection is one of debating issues in the treatment of papillary thyroid carcinoma (PTC). In a previous study, the predictive value of BRAF mutation for lymph node metastasis was only significant in 0.5 to 1.0 cm PTC. Thus, we assess the predictive value of BRAF mutation for central lymph node metastasis according to tumor size.

Methods

Medical records of 3107 patients with PTC who underwent thyroidectomy with central neck dissection were retrospectively reviewed.

Results

BRAF mutation was a predictor for central lymph node metastasis in 2.0 to 4.0 cm PTC (odds ratio [OR] = 3.494; p = .002). Although BRAF mutation was associated with central lymph node metastasis in 0.5 to 1.0 cm PTC in univariate analysis (OR = 1.334; p = .047), this significance was not observed in multivariate analysis (OR = 1.232; p = .163). BRAF mutation was not associated with central lymph node metastasis in other tumor sizes.

Conclusion

Prophylactic central neck dissection could be considered in 2.0 to 4.0 cm PTC with positive BRAF mutation. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1203–E1209, 2016
Host stromal versican is essential for cancer‐associated fibroblast function to inhibit cancer growth
Authors: Fanhchaksai Kanda , Okada Futoshi , Nagai Naoko , Pothacharoen Peraphan , Kongtawelert Prachya , Hatano Sonoko , Makino Shinji , Nakamura Tomoyuki , Watanabe Hideto
Published: August 2015

The stroma provides a microenvironment that regulates tumor cell behavior. The extracellular matrix (ECM) has long been recognized to be important in tumor cell behavior, and previous studies have revealed the impact of individual matrix molecules on tumor progression. Although several reports have highlighted some central roles of tumor cell‐expressed versican, the role of host stromal versican is not yet understood. In this study, we demonstrate that versican is an important molecule in the functional ECM structure and maintaining cancer‐associated fibroblasts, using versican‐negative QRsP11 fibrosarcoma cells. By their subcutaneous injection with cre‐expressing adenoviruses to versican‐floxed mice, we demonstrate that loss of host stromal versican facilitates tumor cell proliferation, and following angiogenesis, decreases cancer‐associated fibroblasts, diminishes collagen fibers and alters hyaluronan distribution, concomitant with upregulation of hyaluronan, TGFβ and VEGF‐mediated signaling. When the versican V3 variant consisting of G1 and G3 domains was expressed in tumor cells, it was integrated into the ECM, regained collagen fibers and cancer‐associated fibroblasts and resulted in successful recovery of tumor growth inhibition, indicating that whatever cells produce, the G1 and G3 domains are adequate for versican function. Collectively, our results indicate a dynamic function of versican in the ECM that regulates tumor cell behavior. A greater understanding of the regulation of versican expression may contribute to the development of cancer therapies.
Regional changes of placental vascularization in preeclampsia: A review
Authors: Sahay Akriti S. , Sundrani Deepali P. , Joshi Sadhana R.
Published: August 2015

Preeclampsia is characterized by vascular dysfunction and results in maternal and fetal morbidity and mortality. The placenta plays a critical role in the growth and development of the fetus, and recent studies indicate that placental architecture, oxygen availability, and oxidative stress indices vary across different regions of the placenta. Our earlier studies have reported altered maternal angiogenesis and differential placental gene expression and methylation patterns of angiogenic factors in women with preeclampsia when compared with normotensive women. We have also demonstrated lower maternal and placental neurotrophin (NT) levels in women with preeclampsia. Studies suggest that oxidative stress is associated with proteases like matrix metalloproteinases (MMPs) and growth factors like NTs and angiogenic factors known to be involved in the process of angiogenesis. Recently, we have reported regionwise differential oxidative stress, antioxidant enzyme activity, and NT levels in placenta from normotensive control women and women with preeclampsia. The current review describes the regional changes in the placenta and highlights the role of placental oxidative stress in influencing regional differences in the expression of angiogenic factors, MMPs, and NTs. This review discusses the need for further research on various growth factors and proteins involved in the process of placental development across different regions of the placenta. This would help to understand whether regional differences in these factors affect the growth and development of the fetus. © 2015 IUBMB Life, 67(8):619–625, 2015