INFECTIONS CAUSED BY VIRAL-BACTERIAL ASSOCIATIONS, THEIR PLACE IN THE STRUCTURE OF CHILDREN'S MORTALITY AND THE MORPHOLOGICAL JUSTIFICATION
Authors:   State Institution ", Torianyk Inna ,   І. Меchnikov Іnstitute of Microbiology and Immunology National Academy of Medical Sciences of Ukraine",   , Ukraine, Popova Natalia ,   Kharkiv National Medical University, Ukraine
Published: June 2023

Тhe widespread spread of infectious diseases, the constant growth of the number of patients with complications and fatal consequences of unrecognized nosology, the lack of clear diagnostic criteria and the prognosis of the latter determine the relevance of the study of diagnostic reserves of mixed infections. The purpose: of the work was to study infections caused by viral-bacterial associations, their place in the structure of children's mortality and the morphological dominance of diseases that occur with respiratory syndrome. Methodology of the study is based on general research methods of analysis of macromicroscopic changes in the organs of the respiratory system in response to the influence of agents of viral-bacterial associations. For this purpose, a complex of morphological techniques (histological, electron microscopic: raster microscopy) and statistical data calculation resources were used. The results. In the presented work, there is a total lack of clinical and epidemiological data on mixed infections (viral-microbial derivative), neglect of facts, and in some cases ignoring the resources of retrospective analysis, comparative episituational characteristics, ambiguity in approaches to the clinical and laboratory interpretation of certain research results. It is shown that the needs of modern practical medicine require a purposeful and detailed study of the basic criteria of complex clinical and morphological diagnostics (organs, target cells), probable morphological assessment of injuries, signal changes in critical organs (respiratory tract, in particular); search and development of new therapeutic measures; measures to prevent mixed infections; forecast of the risk of the latest disease among the children's contingent. The targeting of the mechanisms of the associated action of HSV and Mycoplasma hominis was clearly reflected in the structural and functional specificity of the internal organs involved in the etiopathogenetic picture of diseases caused by complications of HBV. Macroscopically, these facts were manifested by changes in biomechanical, morphometric, syn-, skeleto- and holotopographic indicators. Microscopically: the development of desquamation processes, changes in nuclear-cytoplasmic ratios, destructive-degenerative phenomena, proliferative-inflammatory phenomena, necrosis, thrombostatic manifestations, microcirculation disorders. Submicroscopically, the presence of alterative changes, damage to the membrane structures of cells of mesenchymal origin, marginality of chromatin, pyknosis, karyorrhexis, phenomena of dilatation of microvessels on the example of corrosive drugs were established. Practical implications. The obtained data fully contribute to the well-founded solution of an important practical issue: determining the role of morphological parameters of signal tissues/cells of target organs in the development of unified treatment schemes/algorithms and prognosis of the consequences of viral and bacterial infections. The value/originality lies in the possibility of applying the results of work in modern diagnostic algorithms for full-fledged diagnostics of viral-bacterial associations.