bluuebunny/crossref_metadata_2025 huggingface dataset:
Agreement in Squat Jump Force-Time Characteristics Between Smith Machine and Free-Weight Squat Jump Force-Time Characteristics
Authors: Kotani Yosuke , Lake Jason , Guppy Stuart N. , Poon Wayne , Nosaka Kazunori , Haff G. Gregory
Published: May 2023

Kotani, Y, Lake, J, Guppy, SN, Poon, W, Nosaka, K, and Haff, GG. Agreement in squat jump force-time characteristics between Smith machine and free-weight squat jump force-time characteristics. J Strength Cond Res 37(10): 1955–1962, 2023—The purpose of this study was to determine whether squat jump (SJ) force-velocity (FV) and load-velocity (LV) profiles created using free-weights agree with profiles created with a Smith machine. Fifteen resistance-trained male subjects (age = 26.4 ± 2.5 years; height = 1.75 ± 0.09 m; body mass = 82.6 ± 13.4 kg) participated in this study. All subjects completed 2 familiarization and 2 experimental sessions using both the Smith machine and free-weight SJs each separated by 48 hours. During the experimental trials, progressively loaded SJs were performed in a quasi-randomized block order with loads between 21 kg and 100% of the subject's body mass. Agreement between exercise mode was determined with a weighted least products regression analysis. No fixed or proportional bias was noted between exercise modes when using peak velocity (PV) and mean velocity (MV) to create an FV profile. There was no fixed and proportional bias present for the LV profile when the profile was created with PV. When the LV profile was calculated from MV, fixed and proportional bias were present, indicating that MVs were significantly different between exercise modes. In addition, the free-weight FV and LV profiles exhibited poor to good relative and good to poor absolute reliability. Furthermore, when created using the Smith machine, both profiles exhibited poor to moderate relative and absolute reliability. Based on these data, caution should be used when interpreting LV and FV profiles created with these 2 methods.
Differential Development of Dendritic Spines in Striatal Projection Neurons of Direct and Indirect Pathways in the Caudoputamen and Nucleus Accumbens
Authors: Kuo Hsiao-Ying , Yang Ya-Hui , Chen Shih-Yun , Kuo Tzu-Hsin , Lin Wan-Ting , Liu Fu-Chin
Published: May 2023

Synaptic modification in postnatal development is essential for the maturation of neural networks. Developmental maturation of excitatory synapses occurs at the loci of dendritic spines that are dynamically regulated by growth and pruning. Striatal spiny projection neurons (SPNs) receive excitatory input from the cerebral cortex and thalamus. SPNs of the striatonigral direct pathway (dSPNs) and SPNs of the striatopallidal indirect pathway (iSPNs) have different developmental roots and functions. The spatial and temporal dynamics of dendritic spine maturation of these two types of SPNs remain elusive. Here, we delineate the developmental trajectories of dendritic spines of dSPNs and iSPNs in the caudoputamen and nucleus accumbens (NAc). We labeled dendritic spines of SPNs by microinjecting Cre-dependent AAV-eYFP viruses into newborn Drd1-Cre or Adora2a-Cre mice, and analyzed spinogenesis at three levels, including different SPN cell types, subregions and postnatal times. In the dorsolateral striatum, spine pruning of dSPNs and iSPNs occurred at postnatal day (P)30–P50. In the dorsomedial striatum, the spine density of both dSPNs and iSPNs reached its peak between P30 and P50, and spine pruning occurred after P30 and P50, respectively, for dSPNs and iSPNs. In the NAc shell, spines of dSPNs and iSPNs were pruned after P21–P30, but no significant pruning was observed in iSPNs of lateral NAc shell. In the NAc core, the spine density of dSPNs and iSPNs reached its peak at P21 and P30, respectively, and subsequently declined. Collectively, the developmental maturation of dendritic spines in dSPNs and iSPNs follows distinct spatiotemporal trajectories in the dorsal and ventral striatum.
Selective autophagy regulates chloroplast protein import and promotes plant stress tolerance
Authors: Wan Chen , Zhang Hui , Cheng Hongying , Sowden Robert G , Cai Wenjuan , Jarvis R Paul , Ling Qihua
Published: May 2023

Chloroplasts are plant organelles responsible for photosynthesis and environmental sensing. Most chloroplast proteins are imported from the cytosol through the translocon at the outer envelope membrane of chloroplasts (TOC). Previous work has shown that TOC components are regulated by the ubiquitin‐proteasome system (UPS) to control the chloroplast proteome, which is crucial for the organelle's function and plant development. Here, we demonstrate that the TOC apparatus is also subject to K63‐linked polyubiquitination and regulation by selective autophagy, potentially promoting plant stress tolerance. We identify NBR1 as a selective autophagy adaptor targeting TOC components, and mediating their relocation into vacuoles for autophagic degradation. Such selective autophagy is shown to control TOC protein levels and chloroplast protein import and to influence photosynthetic activity as well as tolerance to UV‐B irradiation and heat stress in Arabidopsis plants. These findings uncover the vital role of selective autophagy in the proteolytic regulation of specific chloroplast proteins, and how dynamic control of chloroplast protein import is critically important for plants to cope with challenging environments.
HNRNPH1 regulates the neuroprotective cold‐shock protein RBM3 expression through poison exon exclusion
Authors: Lin Julie Qiaojin , Khuperkar Deepak , Pavlou Sofia , Makarchuk Stanislaw , Patikas Nikolaos , Lee Flora CY , Zbiegly Julia M , Kang Jianning , Field Sarah F , Bailey David MD , Freeman Joshua L , Ule Jernej , Metzakopian Emmanouil , Ruepp Marc‐David , Mallucci Giovanna R
Published: May 2023

Enhanced expression of the cold‐shock protein RNA binding motif 3 (RBM3) is highly neuroprotective both in vitro and in vivo. Whilst upstream signalling pathways leading to RBM3 expression have been described, the precise molecular mechanism of RBM3 cold induction remains elusive. To identify temperature‐dependent modulators of RBM3, we performed a genome‐wide CRISPR‐Cas9 knockout screen using RBM3‐reporter human iPSC‐derived neurons. We found that RBM3 mRNA and protein levels are robustly regulated by several splicing factors, with heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1) being the strongest positive regulator. Splicing analysis revealed that moderate hypothermia significantly represses the inclusion of a poison exon, which, when retained, targets the mRNA for nonsense‐mediated decay. Importantly, we show that HNRNPH1 mediates this cold‐dependent exon skipping via its thermosensitive interaction with a G‐rich motif within the poison exon. Our study provides novel mechanistic insights into the regulation of RBM3 and provides further targets for neuroprotective therapeutic strategies.
Foreign Ownership, Free Cash Flow, and Assets Utilization of Manufacturing Industry
Authors: Aziza Nurna , S C Rafflesiantono
Published: May 2023

Purpose : This study aims to examine the effect of moderating role of foreign ownership in the relationship between net profit margin and free cash flow on assets utilization in Indonesian manufacturing companies.

Method : Net profit margin and free cash flow act as independent variables while assets utilization is the dependent variable and foreign ownership is the moderating variable. The research sample was determined using a purposive sampling approach with several criteria as the basis for determining it. Observations in this study were conducted from 2018 to 2020, manufacturing companies listed on the Indonesian Stock Exchange were the focus of this study. 36 companies were selected as samples with 108 observations. Testing the research hypothesis was conducted by using Moderated Regression Analysis (MRA).

Findings : The results of the tests showed that asset utilization was positively and significantly impacted by Net Profit Margin and Free Cash Flow. Additionally, foreign ownership was insignificant in strengthening the effect of net profit margin and free cash flow on asset utilization.

Novelty : The study specifically focused on foreign ownership, while previous research was based on structure ownership as a whole.

Keywords : Assets Utilization; Foreign Ownership; Free Cash Flow; Net Profit Margin
The The Effect Of Uncontrolled Addition Of Gelatin In Paracetamol Tablet Formulation And The Evaluation
Authors: Putri Nanda Sabila Fitriana
Published: May 2023

Acetaminophen is a pain-relieving (analgesic) and fever-treating (antipyretic) medication that can be obtained over-the-counter. Wet granulation evaluation of granule among others flow time, angle of repose, tapped density tableting evaluation tablet among others weight uniformity, friability, disintegration time tablet flow time evaluation test was 0.16 with an angle of repose 51.78 tapped density of 30%. Tablet manufacturing process, tablet was damaged during the initial printing, namely capping. The tablet evaluation test obtained weight uniformity 248mg, friability 3.22%, disintegration time 1 minute, dissolution results at 60th minutes is 2.2817. The formulation of paracetamol tablets made by the researchers did not meet the specifications for marketability, where the discrepancy in tablet specifications occurred in the physical and chemical properties of the tablets.
VALIDATION OF ANALYTICAL METHOD FOR THE DISSOLUTION TEST OF VITAMIN D3 5000 IU CHEWABLE TABLETS WITH HPLC AND STABILITY TESTING
Authors: Puti Karin Maharrani Ayu
Published: May 2023

Background: Vitamin D3 is a fat-soluble vitamin. The low solubility of vitamin D3 in water has attracted the researchers to develop a modification of vitamin D3 to be soluble in water, thus increasing  bioavailability of vitamin D3 in the body and improving product performance in vitro and in vivo.

Aim: This study aims to knowing the dissolution analysis method of vitamin D3 chewable tablets with HPLC and the stability of samples vitamin D3 5000 IU at 6th weeks of shelf life with storage conditions of 30 °C ± 2 ℃ and 40 °C ± 2 °C at Rh 75% ± 5%.

Material and Methods: This study refers to USP 43 NF 38 with modifications of mobile phase.

Results: The analytical method used shows linear results with a coefficient of correlation (r) equal to 0,9997. LoD and LoQ  is 0,0076 ppm and 0,02302 ppm. The Q values of intermediate precision test were 86,431% and 85,2182%. The recovery percentage is 96,8147% - 100,1338%. The specificity test shows the analyte can be clearly distinguished from other components. In testing the stability of the test solution were 100,138% and %RSD equal to 0,12903% for 0 hours and 99,2754% and %RSD equal to 0,33193% for 24 hours. In the accelerated stability test, the results at 0 week were 85,2182%, the results at 6 weeks of 30 °C and 40°C is 86,718639% and 82,80894%.

Conclucion: Validation of analytical method has met the acceptance criteria from ICH and USP.
Impact of coronavirus disease 2019 on patients with primary adrenal insufficiency: a cross-sectional study
Authors: Knowles Gregory , Warmington Emily , Shepherd Lisa M , Hazlehurst Jonathan M , de Bray Anne , Gleeson Helena , Arlt Wiebke , Prete Alessandro
Published: May 2023

Objective

Patients with primary adrenal insufficiency (PAI) are thought to be particularly vulnerable to coronavirus disease 2019 (COVID-19); however, little is known about its true impact on this group. We assessed morbidity and health promotion attitudes during the pandemic amongst a large cohort of patients with PAI.

Design

Cross-sectional, single-centre study.

Methods

In May 2020, COVID-19 advice on social distancing and sick-day rules was distributed to all patients with PAI registered with a large secondary/tertiary care centre. A semi-structured questionnaire was used to survey patients in early 2021.

Results

Of 207 contacted patients, 162 responded (82/111 with Addison’s disease, AD; 80/96 with congenital adrenal hyperplasia, CAH). Patients with AD were older than those with CAH (median age 51 vs 39 years; P < 0.001) and had more comorbidities (Charlson comorbidity index ≥2 47.6% vs 10.0%; P< 0.001). By the time of the survey, 47 patients (29.0%) had been diagnosed with COVID-19, the second commonest cause of sick-day dosing during the study and the leading trigger of adrenal crises (4/18 cases). Patients with CAH had a higher risk of COVID-19 compared to AD (adjusted odds ratio 2.53 (95% CI 1.07–6.16), P= 0.036), were less inclined to have the COVID-19 vaccine (80.0% vs 96.3%; P = 0.001), and were less likely to have undergone hydrocortisone self-injection training (80.0% vs 91.5%; P = 0.044) or wear medical alert jewellery (36.3% vs 64.6%; P = 0.001).

Conclusions

COVID-19 was a principal trigger for adrenal crises and sick-day dosing in patients with PAI. Despite a higher risk of COVID-19, patients with CAH showed less engagement with self-protective attitudes.

Significance statement

We conducted a cross-sectional study on a large and well-characterised group of patients with PAI and demonstrated that COVID-19 was a leading cause of morbidity during the early phases of the pandemic. Patients with AD were older and had a greater burden of comorbidity than those with CAH, including non-adrenal autoimmune disorders. However, patients with CAH were more likely to develop COVID-19 and demonstrated reduced engagement with healthcare services and health promotion strategies.
Subsequent pregnancy outcomes among women with tubal ectopic pregnancy treated with methotrexate
Authors: Mackenzie Scott C , Moakes Catherine A , Duncan W Colin , Tong Stephen , Horne Andrew W
Published: May 2023

Graphical abstract

Lay summary

An ectopic pregnancy occurs when an embryo implants outside of the uterus, usually in a fallopian tube. When detected early, treatment is often with a medication called methotrexate. When methotrexate does not work, surgery is required. A recent clinical trial of ectopic pregnancy treatment (called GEM3) found that adding a drug called gefitinib to methotrexate did not reduce the need for surgery. We have used data from the GEM3 trial, combined with data collected 12 months after the trial finished, to investigate post-methotrexate pregnancy outcomes. We found no difference in pregnancy rates, pregnancy loss rates and recurrent ectopic pregnancy rates between those treated medically only and those who subsequently also needed surgery. The surgical technique used also did not affect pregnancy rates. This research provides reassurance that women with ectopic pregnancies treated medically who need surgery have similar post-treatment pregnancy outcomes to those treated successfully medically.
The effect of sperm DNA fragmentation on the incidence and origin of whole and segmental chromosomal aneuploidies in human embryos
Authors: Gao Jiangman , Yan Zhiqiang , Yan Liying , Zhu Xiaohui , Jiang Hui , Qiao Jie
Published: May 2023

In brief

Whether sperm DNA fragmentation (SDF) affects embryo development and clinical outcomes is still controversial, which limits the utility of SDF testing in assisted reproductive technology management. This study demonstrates that high SDF is associated with the incidence of segmental chromosomal aneuploidy and increased paternal whole chromosomal aneuploidies.

We aimed to investigate the correlation of sperm DNA fragmentation (SDF) with the incidence and paternal origin of whole and segmental chromosomal aneuploidies of embryos at the blastocyst stage. A retrospective cohort study was conducted with a total of 174 couples (women aged 35 years or younger) who underwent 238 cycles (including 748 blastocysts) of preimplantation genetic testing for monogenic diseases (PGT-M). All subjects were divided into two groups based on the sperm DNA fragmentation index (DFI) level: low DFI (<27%) and high DFI (≥27%). The rates of euploidy, whole chromosomal aneuploidy, segmental chromosomal aneuploidy, mosaicism, parental origin of aneuploidy, fertilization, cleavage, and blastocyst formation were compared between low- and high-DFI groups. We found no significant differences in fertilization, cleavage, or blastocyst formation between the two groups. Compared to that in the low-DFI group, segmental chromosomal aneuploidy rate was significantly higher in the high-DFI group (11.57% vs 5.83%, P = 0.021; OR: 2.32, 95% CI: 1.10–4.89, P = 0.028). The whole chromosomal embryonic aneuploidy of paternal origin was significantly higher in cycles with high DFI than in cycles with low DFI (46.43% vs 23.33%, P = 0.018; OR: 4.32, 95% CI: 1.06–17.66, P = 0.041). However, the segmental chromosomal aneuploidy of paternal origin was not significantly different between the two groups (71.43% vs 78.05%, P = 0.615; OR: 1.01, 95% CI: 0.16–6.40, P = 0.995). In conclusion, our results suggested that high SDF was associated with the incidence of segmental chromosomal aneuploidy and increased paternal whole chromosomal aneuploidies in embryos.
Characterization of bioenergetic and kinematic plasticity of bovine sperm reveals novel and dynamic temporal traits
Authors: de Agostini Losano Joao D , Souders Christopher L , Martyniuk Christopher J , Daigneault Bradford W
Published: May 2023

In brief

Evaluation of sperm samples with similar motility after thawing has limited value to identify differences in sperm bioenergetic capacity. Maintaining sperm for 24 hr at room temperature is sufficient to detect bioenergetic and kinematics divergences.

Sperm transport through the female reproductive tract requires energy for motility and fertilization. Sperm kinematic assessment is conducted as an industry standard to estimate semen quality prior to bovine insemination. However, individual samples with similar post-thaw motility result in different pregnancy outcomes, suggesting that differences in bioenergetics may be important for sperm function. Thus, characterization of bioenergetic and kinematic parameters of sperm over time may reveal novel metabolic requirements for sperm function. Post-thawed sperm from five samples of individual (A, B, C) and pooled bulls (AB, AC) were assessed at 0 and 24 h after thawing. Sperm were evaluated for kinematics via computer-assisted sperm analyses and bioenergetic profiles using a Seahorse Analyzer for basal respiration (BR), mitochondrial stress test (MST), and energy map (EM). Motility was nearly identical among samples after thawing and no differences in bioenergetics were detected. However, after 24 h of sperm storage, pooled sperm samples (AC) presented with higher BR and proton leakage compared to other samples. Sperm kinematic variability among samples was higher after 24 h, suggesting difference in sperm quality may manifest over time. Despite a reduction in motility and mitochondrial membrane potential, BR was higher at 24 h compared to 0 h for nearly all samples. A metabolic divergence between samples was detected by EM, indicating a shift in bioenergetic profiles over time that was undetected after thawing. These new bioenergetic profiles elucidate a novel dynamic plasticity of sperm metabolism over time while suggesting an influence of heterospermic interactions for further investigation.
Miradas decoloniales desde el arte
Authors: Echeverry Santiago , Rodríguez Denix
Published: May 2023

A partir del trabajo mancomunado entre las sedes y seccionales de la Universidad Santo Tomás en Bogotá, Bucaramanga y Villavicencio, se han abierto nuevos horizontes, dentro de los que se destaca: la búsqueda de nuevas alianzas editoriales y la gestión de la sección de traducciones. Ahora bien, a partir del encuentro entre editores, también han surgido inquietudes epistémicas que orientan y nutren el quehacer editorial y que permite mostrar nuevas facetas de la revista, recorrer caminos conocidos y emprender otros tantos que merecen ser descubiertos, como aquel que se presenta en este número: Miradas decoloniales desde el arte.
Disquisiciones formales sobre la renta disponible
Authors: Monge Mora Marco Vinicio
Published: May 2023

Este trabajo es de índole formal. Presenta 3 proposiciones –una sobre el nivel recaudatorio del impuesto sobre la renta en un entorno sin reacción; otra que prueba, en un contexto estático de equilibrio parcial, que dicho impuesto reduce la utilidad individual; y la última constituye una interpretación alternativa al lema de Shephard.
“Earthly life continues, full of incredible labour...” Letters from metropolitan Elevferiy (Bogoyavlensky) of Lithuania and Vilna to metropolitan Sergius (Stragorodsky)
Authors: Kostryukov Andrey
Published: May 2023

The publication introduces into scientific circulation four letters from Metropolitan Eleutherius (Bogoyavlensky) of Lithuania and Vilna to the Deputy Patriarchal Locum Tenens Metropolitan Sergius (Stragorodsky). The letters are dated 1934. The author of the letters not only headed the Diocese of Lithuania, but also, from 1930, managed the few parishes of the Moscow Patriarchate in Western Europe. Metropolitan Eleutherius reported on important events and problems that arose in the parishes entrusted to him. One of them was the division at the Three Hierarchs Compound in Paris, caused by the wrong parish policy of Archbishop Benjamin (Fedchenkov). Another problem was the appointment of a new rector for the Three Saints Compound in Paris. For some time, the apologist of the Moscow Patriarchate I.A. Stratonov. Metropolitan Eleutherius reported on the situation in the Russian Church Abroad and on the patronage, she received from Patriarch Varnava of Serbia. The author of the letters considered his policy to be wrong and uncanonical. At the same time, the metropolitan spoke about the reconciliation between the head of the Russian Church Abroad, Metropolitan Anthony (Khrapovitsky) and the head of the Western European Russian Exarchate, Metropolitan Evlogy (Georgievsky). The letters reflect other events as well. Among them are the mission of Hieromonk Demetrius (Balfour) among the Anglicans, the last days of Archpriest Sergei Sokolovsky, a hero of the First World War who joined the Renovationist schism and converted to Catholicism, about the attempts of the publicist M.A. Kallash to publish a pamphlet against the Russian Church Abroad, etc. Many of Metropolitan Eleutherius' assessments are biased, but, on the whole, the letters are an important source on the history of Russian Orthodoxy in exile
Alexander i as head of the Holy Alliance: interpretation of the British press
Authors: Latonova Anastasiia
Published: May 2023

In the autumn of 1815, Alexander I created the Holy Alliance, a unique political entity that immediately attracted the attention of the foreign press. The authors of various media put forward many hypotheses as to what was behind the vague formulations of the Act of the Holy Union, what political goals this association had and how they changed. The purpose of this work is to analyze the assessments of the Holy Alliance and Alexander I as its head in English newspapers. The chronological framework of the study – 1816-1825 – is determined by the period of the existence of the Holy Alliance during the life of Alexander I. The article analyzes the perception of the Act of the Holy Union itself by British newspapermen. The reaction of English publications to the conservative policy pursued by the Holy Alliance at the turn of the 1810s-1820s is investigated, the appearance of the "black myth" about Alexander I in the British press is investigated. The article analyzes publications from all British publications that existed at that time. A comparison of publications in liberal and conservative publications was carried out. Conclusions in the article are drawn about the perception of the actions of Alexander I, as the head of the Holy Union, through the prism of the national interests of Great Britain. Conclusions are also given on how the attitude of British authors to the Holy Alliance and to Alexander I personally was changing.
Evaluation of the acid leaching technique for recovery of U3O8 and ThO2 in niobium/tantalum slag
Authors: Moura Vanderlei Vilaça , Santos Talita , Pereira Claubia
Published: May 2023

This study presented the recovery of uranium oxide and thorium oxide from aluminothermic slag from the metallurgical processing of columbite – a niobium/tantalum mineral with the presence of U3O8 and ThO2 – from a mining-industrial facility. The methodology consisted of sampling, comminution, and leaching using sulfuric acid. The head sample showed contents of (1.78 + 0.14) % for U3O8 and (3.66 + 0.04) % for ThO2. The metallurgical recovery reached values above 80% for the uranium oxide and above 70% for the thorium oxide for pH < 1.5 and process time greater than eight hours.
THE CONCEPT OF THE “APPLE SAVIOR” IN THE NOVEL BY I. S. SHMELEV “THE SUMMER OF THE LORD”
Authors: Shestakova Elena
Published: May 2023

The research study aims to reveal the ways in which the concept of “Apple Savior” is artistic embodiment in the novel by I. S. Shmelev “The Summer of the Lord.” The concept of “Apple Savior” is considered in the context of the writer’s value and semantic attitudes, which have undergone significant changes compared to his pre-Revolution creative period. In the author’s artistic consciousness, the image of the garden appears as the metaphorical source and beginning of human life. The narrative structure of the chapter is two-dimensional: it contains the discourse of the child hero and the mature narrator. Within the framework of children’s worldview, the image of the garden is inseparable from the image of the family house, the categories of love, beauty and God’s grace. The image of the garden is connected with the idea of Moscow as a garden and Holy Russia as a garden. In the novel “The Summer of the Lord” there is a generalized image — a symbol of the world transformed by God’s presence and the power of the author’s grateful love. The theme of transfiguration closely approaches the motifs of return and memories, which acquire a pronounced nostalgic tinge and lyrical tonality. The images of temples, the city of Moscow and Russia are associated with the motifs of transfiguration, sacralisation, spirituality, deification and eternity. In recreating the concept of the “Apple Savior” by I. S. Shmelev, the artistic method of “spiritual realism” fully manifested itself. The chronotope of the real world in the novel “The Summer of the Lord” appears in close connection with the existential sphere, is comprehended by God’s world. The theme of memory and grateful love establishes the discourse of a mature narrator. The world of childhood and Homeland is recognized as a lost biblical paradise, and becomes the subject of persistent thoughts and reflections of the author.
COMBINED NANOCHEMOTHERAPY USING DOXORUBICIN AND CURCUMIN AS AN EXAMPLE
Authors:   Palladina Institute of Biochemistry of the National Academy of Sciences of Ukraine, Kyiv, KANIUK M. I.
Published: May 2023

The aim of the work was to review literature data on combined nanochemotherapy using the example of two drugs ̶doxorubicin and curcumin. Special attention was paid to the use of substances with synergistic properties in one nanoparticle, capable to penetrate into living cell. The method of combined chemotherapy of nanopreparations improves processing efficiency. The technique of using nanocontainers with synergistic drugs in combination with ligands reduces the side effects of chemotherapy drugs. Results. Literature data indicate that the use of nanopreparations contributes the rapid creation and use of synergistic combinations that were purposefully delivered to target cells, reducing dosage due to precise targeting. A promising direction of nanomedicine is the creation of multifunctional nanomaterials based on several active drugs having synergistic properties, with the simultaneous use of their enhancers and the strategy of active targeting. These structures enabled targeted and controlled penetration of medicinal compounds into the localization of pathological processes, reducing drugs toxicity for normal cells. Conclusions. Combined chemotherapy using polymers and nanoparticles with ligands, in which synergistic drugs are included, ensures to reduce side effects and doses of chemotherapy drugs, and helps to overcome multiple drug resistance as well.
DETERMINING OF NUTRITIONAL VALUE OF CAVIAR OF SIBERIAN STURGEON IN UKRAINE
Authors:   National University of Life and Environmental Sciences of Ukraine, Kyiv, Palamarchuk Ihor P.
Published: May 2023

Aim. The purpose of the work was to study the nutritional value of siberian sturgeon caviar Acipenser baerii, grown in aquaculture conditions in the Dnieper reservoirs of Ukraine, and to compare its quality indicators with this product produced abroad. Methods: There are identified organoleptic properties of siberian sturgeon caviar, and its energetic value, composition of amino acids in albumens and content of fatty acids in lipids of the product. The data obtained in the research were compared with the same indices of quality of caviar of sturgeons bred abroad. Results. The organoleptic properties of siberian sturgeon caviar bred in Ukraine (appearance, color, consistency, taste and aroma) conformed to its standardized indices of quality. The caviar contained all eight essential amino acids and belonged to category of products rich by albumen (21.54±2.13%),and fats eicosapentaenoic and docosahexaenoic ω-3 acids (3.46 % and 11.2 %, respectively). (13.20±0.93%). The big content of fat, especially of polyunsaturated fatty acids and 3 acids (the eicosapentaenoic and docosahexaenoic ones — 3.46 % and 11.2 %, respectively) is one more factor, which enables to identify thes siberian sturgeon caviar as the product of high biological value. It was shown that the caviar of siberian sturgeon produced in Ukraine is in close coincidence with those that were produced in other countries. Conclusions. The totality of studied characteristics of caviar of siberian sturgeon produced in Ukraine witnesses its high nutritional value. Therefore this product may be recommended in prophylactics of numerous illnesse and strengthening of state of health.
ОПТИМІЗАЦІЯ ПАРАМЕТРІВ БІОКАТАЛІТИЧНОГО ГІДРОЛІЗУ РОСЛИННОЇ ОЛІЇ З ВИКОРИСТАННЯМ МЕТОДІВ НЕЙРОННИХ МЕРЕЖ І ГЕНЕТИЧНИХ АЛГОРИТМІВ
Authors: Некрасов Павло О. , Березка Тетяна О. , Некрасов Олександр П. , Гудзь Ольга М. , Мольченко Світлана М. , Руднєва Світлана І.
Published: May 2023

В теперішній час забезпечення конкурентоспроможності вітчизняної олійно-жирової продукції на внутрішньому та зовнішніх ринках повинне бути реалізоване за рахунок наукоємного виробництва на основі впровадження інновацій, які забезпечують якісно новий ступінь розвитку технологій. У зв'язку із цим у представленій роботі виконано дослідження щодо оптимізації параметрів біокаталітичного гідролізу соняшникової олії. В якості біокаталізатора був використаний ферментний препарат NovoCor AD L («Novozymes», Данія). Для моделювання процесу було застосовано математичний апарат штучних нейронних мереж. Розроблена в результаті конструювання, навчання і верифікації тришарова мережа прямої передачі сигналу використовувалась для обчислення функції пристосованості при оптимізації біокаталітичного гідролізу методом генетичних алгоритмів. Програмну реалізацію математичного апарату було виконано у середовищі MATLAB. Проведені дослідження дозволили встановити оптимальні значення основних параметрів біокаталітичного гідролізу рослинної олії: мольне співвідношення води до олії – 14 : 1, кількість ферменту – 3.75 % по відношенню до маси олії, температура – 60 °С, час реакції – 480 хвилин. Встановлені оптимальні параметри були апробовані в умовах дослідно-промислового виробництва. Відповідно до результатів випробувань ступінь гідролізу олії складав 96 ± 1.8 %, що добре корелюється із даними моделювання.
УДОСКОНАЛЕНИЙ ТЕРМОДИНАМІЧНИЙ ЦИКЛ ПАРОТУРБІННОЇ УСТАНОВКИ
Authors: Лавренченко Георгій К. , Слинько Олексій Г. , Бойчук Артем С. , Галкін Віталій М. , Козловський Сергій В.
Published: May 2023

У сучасних паротурбінних установках пара перегрівається в ізобарному процесі. Як відомо з технічної термодинаміки, за нагрівання робочого тіла від заданого стану до однакової температури, теплота за ізобарного процесу більша, ніж за ізохорного. Крім того, розширення робочого тіла в ізобарному процесі підведення тепла є шкідливим, оскільки не виконується зовнішня робота і втрачається фізичне розширення з метою отримання зовнішньої механічної роботи. В ізохорному процесі пара, подібно до механічної пружини, накопичує більше механічної енергії за менших витрат теплоти. Тому в паротурбінних установках пропонується як первинний перегрів, так і подальші процеси перегріву пари здійснювати ізохорно. Порівняльні розрахунки характеристик паротурбінної установки, що працює за циклом Ренкіна з первинним перегрівом пари до тиску 6.0 МПа і температури 600 °C (тиск пари в конденсаторі 0.004 МПа) з характеристиками установки з ізохорним процесом перегріву пари за тих самих вихідних даних, показали значні енергетичні та економічні переваги останньої в порівнянні з базовою. Так, за менших витратах палива в модифікованій установці (на 10.1 %) її питома робота зросла на 3.9 %, а тепловий ККД – на 11.2 %. Ще суттєвіші енергетичні та економічні переваги має модифікована ПТУ з одним додатковим підігрівом пари: за меншої витраті палива на 15.9 % питома робота зросла на 6.8 %, а тепловий ККД – на 18.8 %. Завдяки меншим об'ємам пари в кінці розширення масогабаритні параметри турбін і конденсатора модифікованої установки зменшуються на 5.2 % порівняно з базовою установкою. Враховуючи наведені вище висновки та масштаби використання ПТУ на сучасних електростанціях, де використовується до десяти проміжних пароперегрівів, запропонована модернізація їх термодинамічних циклів гарантує ще більший енергетичний та економічний ефекти.
El documental audiovisual como apoyo para la investigación de procesos artísticos: El caso de Río Pirro
Authors: Cruz García Adrián
Published: May 2023

En el 2012, como parte de los proyectos financiados con el Fondo de Iniciativas Interdisciplinarias del Centro de Investigación, Docencia y Extensión Artística (CIDEA) de la Universidad Nacional (UNA) de Costa Rica, se realiza el montaje escénico denominado Río Pirro, dirigido por la artista Elia Arce, junto con la Compañía de Cámara de la Escuela de Danza (CCDUNA). Esta obra, centrada en el contaminado río Pirro, que surca el centro de Heredia y el campus central de la Universidad Nacional, fue realizada bajo una visión interdisciplinaria que integraba elementos no solo de la danza, sino también de la performance y de las intervenciones del paisaje urbano. Como parte del proyecto, se realizó un extensivo registro audiovisual del proceso de creación del espectáculo, que finalmente se tradujo en un documental homónimo estrenado en el 2016. Habiéndose reunido mucha más información de la que se pudo incluir en dicha obra audiovisual, se decidió aplicar la metodología de investigación basada en la práctica de las artes y los medios audiovisuales, la cual propone acompañar el producto audiovisual sobre un proceso artístico con un ensayo que profundice en antecedentes, eventos y aspectos metodológicos de la experiencia creativa, que el formato audiovisual no logra abarcar. Este es dicho ensayo.
masonería madrileña en la primera mitad del siglo XX de Manuel Según-Alonso
Authors: Hottinger Craig Sylvia
Published: May 2023

Reseña de La masonería madrileña en la primera mitad del siglo XX de Manuel Según-Alonso Madrid: Editorial Sáez y Torres, 2019. 405 páginas. ISBN 978-84-17765-90-3.
Breves reflexiones sobre la falta de impacto de la masonería femenina o mixta en la sociedad italiana
Authors: Locci Emanuela
Published: May 2023

Este trabajo verifica y analiza el impacto de la masonería femenina o mixta en Italia y la capacidad de las obediencias de comunicar con la sociedad profana.  Para ello se procederá con una investigación empírica a través de cuestionarios sobre el conocimiento que tiene el italiano medio de la masonería femenina o mixta.  A continuación, a través de una serie de entrevistas con miembros de la institución masónica, explicaremos los resultados sobre las características de la mujer masona o en la masonería mixta.  Además, se incluirá un cuadro con las diversas Obediencias de masonería femenina o mixta en Italia.
Crossroads of Gender and Freemasonry
Authors: Côrte Real de Camargo Felipe , De los Reyes Heredia Guillermo
Published: May 2023

In this Dossier on “Gender and Freemasonry” we argue that such topics have to be studied in the specific cultural context in which they were developed. Regarding the complex term of gender, we based our approach in the works of gender scholar, Judith Butler. In her works Gender Trouble and Bodies That Matter, she proposes a social and cultural constructivist approach to gender. In Gender Trouble Butler utilizes Michel Foucault’s thesis that power is productive of gender and sexuality. In Bodies That Matter she introduces a more sophisticated view of the study and conception of gender, as a performance or performativity.
“La masonería es un enemigo que no se rinde jamás”
Authors: Morales Ruiz Juan José
Published: May 2023

Este artículo trata del envío de un agente secreto franquista al México de Cárdenas para espiar a los refugiados republicanos españoles. Un Informe del Servicio de Información y Policía Militar (SIPM) de 1939, informa que a partir del mes de octubre de 1939, un agente instalado en la capital mexicana se infiltrará entre la colonia española y los refugiados republicanos para desestabilizar la inmediata campaña electoral y, sobretodo, vigilar el llamado “oro español”, que depositaron Negrín e Indalecio Prieto, con la complicidad del Presidente Cárdenas, en el Banco Nacional de México al huir de España tras la guerra civil española.
Masonería y masones en la política saltillense
Authors: Díaz Martínez Leonardo Emmanuel
Published: May 2023

Entrevista

Masonería y masones en la política saltillense. Estudio de caso de la logia Fraternidad número 20 (1919-1934)

Leonardo Emmanuel Díaz Martínez

Universidad Autónoma de Coahuila, México

Tesis de licenciatura en Historia defendida en la Universidad Autónoma de Coahuila en México, el 11 de diciembre del 2020. https://doi.org/10.15517/rehmlac.v13i2.46748

Esta entrevista se efectúo de forma telemática el 06 de abril del 2021.

Autores de la entrevista: Ricardo Martínez Esquivel e Yván Pozuelo Andrés, director y editor de REHMLAC+.
Masonería y socialismo: la disputa por la reforma educativa en Saltillo, 1933-1937
Authors: Díaz Martínez Leonardo Emmanuel
Published: May 2023

Este artículo pretende acercarse a las acciones tomadas por algunos masones que se iniciaron en la logia “Fraternidad N° 20”, de la ciudad de Saltillo (México), a partir de la reforma educativa socialista de 1934 que impulsó el presidente Lázaro Cárdenas. Durante su gobierno se puso en marcha la reforma educativa socialista con base en los cambios que se le hicieron al artículo 3° de la Constitución general de 1917, donde la educación primaria quedó bajo el control del Estado. Esto trajo enfrentamientos con los sectores conservadores (padres de familia e Iglesia católica), generando una disputa de ideología político-social.
Apercepciones sobre la iniciación masónica de Javier Alvarado Planas
Authors: Sánchez Ferré Pere
Published: May 2023

Reseña

Apercepciones sobre la iniciación masónica de Javier Alvarado Planas. Alcorcón: Sanz Y Torres, S. L. 2019. 280 páginas. ISBN: 9788417765927.
Masonería española en Marruecos de Valeria Aguiar Bobet
Authors: Morales Ruiz Juan José
Published: May 2023

La masonería española en Marruecos de Valeria Aguiar Bobet, Santa Cruz de Tenerife: Ediciones Idea, 2021. 1490 páginas. ISBN: 978-84-13138-27-0.
Francs-Maçons Arméniens et la Costitution de l’Arménie ottomane, Constantinople 1863 de Onnik Jamgocyan
Authors: Locci Emanuela
Published: May 2023

Les Francs-Maçons Arméniens et la Costitution de l’Arménie ottomane, Constantinople 1863 de Onnik Jamgocyan. París: Les Editions du Bosphore, 2017. 279 páginas. ISBN: 9782956039402.
Masonería en Málaga a finales del XIX
Authors: García Juan Ramón Ojeda
Published: May 2023

Entrevista a Juan Ramón Ojeda García sobre su tesis de doctorado en Historia "La Masonería en Málaga a finales del XIX", defendida en la Universidad de Sevilla en España, el 5 de julio de 2021.
Masonería y espacio público
Authors: Annecchini Mariana , Rodriguez Ana María T.
Published: May 2023

Presentación del volumen 14, número 1 de la REHMLAC+.
Franco y la masonería. Un terrible enemigo que no se rinde jamás de Juan José Morales Ruiz
Authors: Aguiar Bobet Valeria
Published: May 2023

ReseñaFranco y la masonería. Un terrible enemigo que no se rinde jamás de Juan José Morales Ruiz. Oviedo: Masónica.es, 2022. 543 páginas. ISBN: 978-84-19044-30-3.
Is masonry a religión?
Authors: Mola Aldo Alessando
Published: May 2023

When answering the question of whether freemasonry is a religion or not, one needs only to clarify the origins, nature, and purpose of Freemasonry and that of the Catholic Church. It is, evidently, an impossible task to achieve here. Since we cannot avoid approaching the topic, so we can only offer some guidelines for discussion in an attempt to answer these questions.
MENEMUKAN MAQASHID AL-SYARI'AH: AL-SABR WA AL-TAQSIM, THARD DAN TANQIH AL-MANATH
Authors: Rahmi Nailul
Published: May 2023

Maqashid al-syariah adalah untuk kemaslahatan manusia baik di dunia maupun di akhirat. Namun Allah tidak menjelaskannya secara tegas apa saja yang menjadi tujuan dari pensyari'atan syariahNya. Allah hanya menjelaskan sebab-sebab, atau syara-syarat, atau keadaan-keadaan atau sifat-sifat yang mendorong atau hendak dicapai pembuat Syari’at suatu hukum. Oleh karena itu para ulama berijtihad untuk memahami dan mencari tujuan-tujuan dan alasan-alasan pensyari'atan hukum. Untuk memahami dan mencari tujuan-tujuan hukum ini dilakukan oleh para ulama dengan memahami dan mencari “illat hukum dan memahami apa kemaslahatan yang ditimbulkan oleh hukum-hukum tersebut, yang dikenal dengan istilah ta'lil al-hukm. Untuk melakukan ta'lil al-hukm para ulama menempuh beberapa cara yang dikenal dengan istilah masalik al-'illah, diantaranya adalah dengan al-sabr wa al-taqsim, al-thard dan tangih al-manath.

Penggunaan cara masalik al-'illah untuk menentukan magashid al-ahkam, adalah karena dengan menemukan “illat suatu hukum, maka akan diketahui apa alasan dan tujuan ditetapkannya suatu ketetapan hukum. Hal ini disebabkan karena adanya hubungan antara alasan-alasan pensyariatan hukum dengan tujuan kemaslahatan yang akan dicapai oleh manusia, baik dalam bentuk pengambilan manfa'at ataupun menghindari kemufsadatan.
KEENGGANAN IBU MEMBERIKAN AIR SUSU IBU (ASI) KEPADA ANAK DALAM PERSPEKTIF HUKUM ISLAM
Authors: Fauziah Ezi Ainur , Firdaus Firdaus , Khalida Azhariah
Published: May 2023

This research was motivated by the fact that breast milk is the most important and best nutrition for babies from birth, but what happened in Tanjung Senang District was different. there are mothers who are reluctant to give breast milk to their children for various reasons, both acceptable and unacceptable reasons. The formulation of the problem in this study is how the views of Islamic law on the reluctance of a mother to give breast milk (ASI) to children in Tanjung Senang District, Lampung. This type of research is a field research using a descriptive qualitative approach. The approach in this study was intended to identify and describe the reluctance and implementation of breastfeeding by mothers in Tanjung Senang District, Lampung. The technique of collecting data in this research is by interviewing mothers, health workers and religious leaders. Based on the research conducted, it can be concluded that some mothers are reluctant to give breast milk to their children. The reluctance of mothers that occurred in Tanjung Senang District not to breastfeed for various reasons. There is a lack of knowledge, work, breastfeeding is the same as formula milk, lifestyle, breast milk doesn't come out, cannot get support from family and some people's habit of replacing breast milk with other drinks and foods. According to Islamic law, breastfeeding is mandub or recommended. The law of mandub can become mandatory if it harms the soul or the growth of the baby. On this basis, the mother does not give breast milk without a clear reason and contrary to the Shari'a that the mother is seen as lacking in carrying out her religion and obligations because it will make the baby's growth unfulfilled.
ROOTING FIQH IN MODERN IJTIHAD: ADAPTING FIQH TO COMMUNITY NEEDS
Authors: Ridho Muhammad
Published: May 2023

In the face of the changing position of Sharia in the modern state, the contemporary jurist found himself facing the task of covering huge developments with jurisprudential rulings. He devised a jurisprudential mechanism called "rooting," which allowed him to practice ijtihad and cross between the previously restricted sects. To prove the validity of Sharia for modern times and its compatibility with the time requirements, through which he hopes to restore Sharia to its ancient position. This research explains this new jurisprudential mechanism and the jurisprudential practice. It was carried out through examples of political and economic fields; the areas most affected by the new transformations are clear and influential in daily life. These examples reveal the nature of this jurisprudential practice that led to the logic governing the breaking of the Islamic jurisprudence and its adaptation to the age requirements. Although it represents a current between other jurisprudential currents, this practice reveals the predicament of the jurist in the modern world and the complex dilemma he faces. If he met the age requirements and legislated them by breaking the rules and logic of jurisprudence, he strengthened the weakness of the Sharia in influencing public life. If he stood in the face of these requirements, he maintained the isolation of Sharia. In both cases, the jurist consolidates the position of Sharia imposed by the modern state outside the influence of public life.