bluuebunny/crossref_metadata_2025 huggingface dataset:
Levels of type XVII collagen (BP180) ectodomain are elevated in circulation from patients with multiple cancer types and is prognostic for patients with metastatic colorectal cancer
Authors: Crespo-Bravo Marina , Thorlacius-Ussing Jeppe , Nissen Neel I. , Pedersen Rasmus S. , Boisen Mogens K. , Liljefors Maria , Johansen Astrid Z. , Johansen Julia S. , Karsdal Morten , Willumsen Nicholas
Published: June 2023

Background:
Collagens are the major components of the extracellular matrix (ECM) and are known to contribute to tumor progression and metastasis. There are 28 different types of collagens each with unique functions in maintaining tissue structure and function. Type XVII collagen (BP180) is a type II transmembrane protein that provides stable adhesion between epithelial cells and the underlying basement membrane. Aberrant expression and ectodomain shedding of type XVII collagen have been associated with epithelial damage, tumor invasiveness, and metastasis in multiple tumor types and may consequently be used as a potential (non-invasive) biomarker in cancer and treatment target.
Method:
An ELISA targeting the type XVII collagen ectodomain (PRO-C17) was developed for use in serum. PRO-C17 was measured in a cohort of patients with 11 different cancer types (n= 214) and compared to healthy controls (n=23) (cohort 1). Based on the findings from cohort 1, PRO-C17 and its association with survival was explored in patients with metastatic colorectal cancer (mCRC) treated with bevacizumab in combination with chemotherapy (n=212) (cohort 2).
Results:
PRO-C17 was robust and specific towards the ectodomain of type XVII collagen. In cohort 1, PRO-C17 levels were elevated (p < 0.05) in serum from patients with CRC, kidney, ovarian, bladder, breast, and head and neck cancer compared to healthy controls. PRO-C17 was especially good at discriminating between CRC patients and healthy controls with an AUROC of 0.904. In cohort 2, patients with mCRC and high levels (tertile 3) of PRO-C17 had shorter overall survival (OS) with a median OS of 390 days compared to 539 days for patients with low levels of PRO-C17. When evaluated by multivariate Cox regression analysis, high PRO-C17 was predictive for poor OS independent of risk factors and the tumor fibrosis biomarker PRO-C3.
Conclusion:
PRO-C17 measures the ectodomain of type XVII collagen in serum and is a promising non-invasive biomarker that can aid in understanding tumor heterogeneity as well as elaborate on the role of collagen XVII in tumor progression. Moreover, the findings in the study proposes PRO-C17 as novel biomarker of epithelial damage in specific cancer types including CRC.
D-shaped nematode eggs in the feces of Rangifer tarandus: A story in pictures
Authors: Loginova Olga
Published: June 2023

D-shaped nematode eggs in Rangifer tarandus feces are expected to be oxyurid nematodes of the genus Skrjabinema. The species S. tarandi is considered species-specific for this host. There is no consensus regarding the cross-infection of reindeer and sheep with S. ovis and S. tarandi. The drawings proposed by researchers complicate differential diagnostics. Micrographs of S. tarandi eggs obtained via light microscopy and scanning electron microscopy, as well as photographs of S. ovis eggs, and drawings made on their basis, are proposed to confidently distinguishing between representatives of these two species, taking into account morphometric data. Thus, the egg of S. tarandi has a thickening on the convex side, in contrast to the egg of S. ovis. It is shown that due to the specific feeding habits of R. tarandus, D-shaped eggs of parasitic nematodes of small rodents can also be found in their feces. The latter should be considered spurious parasites.
Hydrothermal synthesis of rod shaped red emitting Gd 2 O 3 :Eu 3+ phosphor
Authors: Wangkhem Ranjoy , Singh O. Shantajit , Singh N. Shanta
Published: June 2023

Simple hydrothermal method can be applied for synthesizing rod shape Gd2O3:Eu3+ phosphors. X-ray diffraction, Fourier transform infrared spectroscopy and transmission electron microscopy are used for the characterizations of samples. Increase of Eu3+ concentration in Gd2O3:Eu3+ can cause red shift in the charge transfer band (CTB) of Eu – O. The nature of Eu3+ surroundings is asymmetric. It is ascertained from PL emission studies. The calculation of second order crystal field parameter from PL spectra corroborates the asymmetric environment of Eu3+. PL emission and decay lifetime studies confirm the existence of quenching due cross-relaxation. The quantum yield for Y2O3:Eu3+ (19 at.%) under 265 nm excitation is found to be 7%.
Correlation analysis of abdominal visceral fat area with the structure and function of the heart and liver in severe obesity: A prospective magnetic resonance imaging study
Authors: Bai Jinquan , Gao Chao , li Xiaolu , Pan Hong , Wang Shuting , Shi Zhenzhou , Zhang Tong
Published: June 2023

Background
The differences in fat deposition sites exhibit varying degrees of systemic inflammatory response and organ damage, especially in severely obese individuals with excessive visceral fat, which is closely related to an increase in mortality rates related to heart and liver diseases. However, few studies have analysed the differences in heart and liver indicators between groups and their correlation based on abdominal visceral fat area (AVFA) as a grouping condition.
Objective
Clarifying the changes in the heart and liver caused by differences in abdominal visceral fat in severely obese individuals and their correlation can help us prevent heart diseases with higher mortality rates in advance and control the progression of liver injury.
Methods
Sixty-nine severely obese subjects were enrolled, with a study group of forty-one individuals (AVFA ≥ 150 cm2) and a control group of twenty-eight individuals (100 cm2 ≤ AVFA < 150 cm2). The differences and correlations between clinical, laboratory, and magnetic resonance imaging (MRI) indicators of the heart and liver between the two groups were analysed.
Results
In the study group, the proportion of type 2 diabetes mellitus (T2DM) and insulin resistance level were higher, and liver function indicators were worse. The left ventricular eccentricity ratio (LVER), left ventricular mass (LVM) and global myocardial wall thickness (GPWT) in the study group were higher than those in the control group (P = 0.002, P = 0.001, P = 0.03), and the left ventricle global longitudinal strain (LVGLS) was lower than that in the control group (P = 0.016). Pericardiac adipose tissue volume (PATV) and myocardial proton density fat fraction (M-PDFF) were higher than those in the control group (P = 0.001, P = 0.001). The hepatic proton density fat fraction (H-PDFF) and abdominal subcutaneous fat area (ASFA) were higher than those in the control group (P < 0.001, P = 0.012). There was a moderate positive correlation (ρ = 0.39 ~ 0.59, P < 0.001) between AVFA and LVER, LVM, GPWT, LVGLS, and H-PDFF. There was no difference in right ventricular and most left ventricular systolic and diastolic function between the two groups.
Conclusion
The high AVFA group had a larger LVM, GPWT and PATV, more obvious changes in LVER, impaired left ventricular diastolic function, an increased risk of heart disease, and more severe hepatic fat deposition and liver injury. Therefore, reducing AVFA in severely obese individuals is beneficial for the heart and liver.
Exploring Gender Differences in Associations Between Appetitive Traits, Negative Affect, and Binge Eating in Treatment-Seeking Adults with Overweight or Obesity
Authors: Pasquale Ellen K. , Strong David R. , Manzano Michael A. , Eichen Dawn M. , Boutelle Kerri N.
Published: June 2023

Binge eating (BE) in adults with overweight or obesity (OW/OB) is associated with negative affect and appetitive traits (i.e., food responsiveness, satiety responsiveness, and reward-based eating). While these risk factors may be important intervention targets, they have not been evaluated concurrently, nor for gender consistency. Multigroup structural equation modeling assessed gender differences in associations between negative affect, appetitive traits, and BE among 293 treatment-seeking adults with OW/OB (m age = 46.6; m body mass index[BMI] = 34.5; 81.2% female; 20.1% Latinx, 60.8% white non-Latinx), adjusting for age, race/ethnicity and BMI. Separate models examined BE measured by the BE Scale (BES) total score and past month binge days measured by the Eating Disorder Examination Questionnaire (EDEQ). Both models demonstrated good model fit (CFI > 0.99, RMSEA < 0.03, SRMR < 0.06). BES scores were associated with negative affect (F:β = 0.17; M:β = 0.14) and appetitive traits (F:β = 0.57; M:β = 0.57) among both females and males (p’s ≤ 0.01). Binge days were associated with negative affect (β = 2.14) and appetitive traits (β = 1.48) in females (p’s < 0.01), but not males (p’s ≤ 0.30). A consistent covariance was observed between negative affect and appetitive traits across genders (r’s = 0.42–0.47, p’s ≤ 0.001). Conceptual models of BE should consider the joint role of negative affect and appetitive traits, as together these constructs may represent a larger risk factor for BE, particularly in adults with OW/OB. Future studies should evaluate potential gender bias in existing BE measurement tools, as the present study demonstrated inconsistent associations in males depending upon how BE was assessed.
A head-to-head comparison of the measurement properties of EQ-5D-3L and EQ-5D-5L in family caregivers of cancer patients
Authors: Zhang Huan , Liu Bo , Gu Wen , Cao Yiyin , Xu Juan , Tan Rachel Lee-Yin , Chang Enxue , Zheng Wanji , Li Haofei , Zhou Lan , Jia Yanni , Yang Hongbin , Guo Sheng , Huang Weidong , Luo Nan
Published: June 2023

Background Although both EQ-5D-3L(3L) and EQ-5D-5L(5L) have demonstrated good measurement properties in several patient populations, there is currently limited evidence comparing the measurement properties of 3L and 5L in family caregivers (FCs) of cancer patients.
Purpose This study aimed to compare the measurement properties of 3L and 5L in a sample of family caregivers of cancer patients.
Methods A consecutive sample of FCs of cancer patients recruited from three tertiary hospitals were invited to complete the two versions of the EQ-5D in two rounds of interviews. We compared i) the ceiling effect using the McNemar’s test, ii) test-retest reliability using intraclass correlation coefficient (ICC) and Cohen’s Kappa, iii) convergent validity using Spearman’s rank correlation coefficient, iv) known-group validity using F-statistic, v) and discriminant capacity using ordinal logistic regression.
Results A total of 416 FCs completed the baseline questionnaire and 120 caregivers completed the follow-up questionnaire. Ceiling effects were smaller in 5L (12.5%) than in 3L (20.7%). The convergent validity (r=0.344-0.771), known-groups validity (Fratio5L/3L=2.06-4.09), discriminant capacity (ES=0.341-0.396), and test-retest reliability (Kappa = 0.619-0.722 and ICC= 0.725) of the 5L were slightly better than those of the 3L.
Conclusion The current study found both 3L and 5L to be suitable for use by FCs of cancer patients. However, 5L showed superior measurement properties compared to 3L and therefore could be the preferred instrument when EQ-5D data of cancer patients FCs is required.
Discovery of Ferroelectricity in Natural Product Androstane
Authors: Xiong Ren-Gen , Zhang Han-Yue , Jiang Huan-Huan
Published: June 2023

Progesterone and its derivatives attracted widespread interest because of their applications in medicine, health care and birth control, which is the main active ingredient of contraceptive pills known as one of the five chemistry discoveries that changed human life. Although the research of pharmacological effects on contraceptive pill-related compounds has been around for decades, their ferroelectricity has long been overlooked. Here, we report that 4-androsten-3-one-5-ene-17-carboxylic acid, a derivative of progesterone, is an organic single-component ferroelectric, as confirmed by the polarization − electric field hysteresis loops. It crystallizes in the monoclinic space group P21 with a polar packing structure and undergoes a reversible structural phase transition at a high temperature of 489 K. Thermal analysis revealed that its ferroelectricity can persist up to 533 K, giving a wide working temperature range. As the first ferroelectric in steroid biomaterials, 4-androsten-3-one-5-ene-17-carboxylic acid shows great potential in applications for flexible devices, biomedical devices, bio-machines and so on.
Objective image quality evaluation in a brain dedicated PET scanner
Authors: Teresa Gandia-Ferrero Maria , Irene Torres-Espallardo , Begoña Martínez-Sanchis , Constantino Morera-Ballester , Enrique Muñoz , Pablo Sopena-Novales , Gabriel González-Pavón , Luis Martí-Bonmatí
Published: June 2023

The image quality of a brain-dedicated PET system (CMB) compared to that of a whole-body PET/CT scanner has been evaluated. To that goal, Hoffman phantom and patient data were obtined with both devices. Since CMB does not use a CT for attenuation correction (AC) which is crucial for PET images quality, this study includes the evaluation of CMB PET images using emission-based or CT-based attenuation maps. PET images were compared using 34 image quality metrics. Moreover, a neural network was used to evaluate the degree of agreement between both devices on the patients diagnosis prediction. Overall, results showed that CMB images have higher contrast and recovery coefficient but higher noise than PET/CT images. Although SUVr values presented statistically significant differences in many brain regions, relative differences were low. An asymmetry between left and right hemispheres, however, was identified. Even so, the variations between the two devices were minor. Finally, there is a greater similarity between PET/CT and CMB CT-based AC PET images than between PET/CT and the CMB emission-based AC PET images.
Link prediction grounded upon complex networks based model, based on MJMI-RW
Authors: Bakhat Khush , Kifayat Kashif , Islam M Shujah , Islam M Mattah
Published: June 2023

Link prediction is the process of predicting the connection probability between two nodes based on observable network data, such as network structural topology and node properties. Despite the fact that traditional similarity-based methods are basic and effective, their generalisation performance varies greatly across networks. In this paper, we propose a novel link prediction approach, MJMI-RW, based on the Maxwell Jüttner distribution endowed by the Mutual Information, which recovers the probability of a node's connection by applying node characteristics to a system with less computation. Initially, the method investigates a comprehensive node feature representation by combining diverse structural topology information with node importance properties through feature construction and selection. The selected node features are then fed into a supervised learning task that solves the features matrix using the node features as input. The enhancements of MJMI-RW in terms of the average area under the curve and the precision of state-of-the-art algorithms compared to the finest baseline networks when compared to baseline methods. The limitation of MJMI-RW is its minimal computational complexity feature construction and substitution of complex features with semantic node attributes. Moreover, since inductive matrix completion is a supervised learning task in which the underlying low-rank matrix can be solved by representative nodes instead of all their nodes, it offers a potential link prediction solution for large-scale networks.
Effect of Alccofine on Water Absorption and Sorptivity of Engineered Cementitious Composites Containing Mono and Hybrid Synthetic Fibres
Authors: Ramdass Prashanthi , Kuppusamy Natarajan
Published: June 2023

Water ingression has major influence on durability of concrete materials. This paper deals with a study on influence of Alccofine and synthetic fibers on sorptivity and water absorption in ECC and Hybrid ECC. The sorptivity test measures the rate of movement of water through the concrete under capillary suction as per ASTM C 1585. Water absorption, density and volume of permeable pores in concrete were measured based on ASTM C 642. Based on the literatures, mix design was adopted and fly ash has been replaced by Alccofine and for the workability viscosity modifying agent was used at 0.6% of the binder for all the mixtures. Two types of synthetic fibers, uncoated polyvinyl alcohol (PVA) and polypropylene (PP) were used. The results show that, both ECC and HECC with Alccofine show lower absorption and not much variation in sorptivity than conventional concrete.
Association Between Periprocedural Myocardial Injury And Intra-intimal Microvessels：An Optical Coherence Tomography Study
Authors: Shen Youcheng , Liu Zhijiang , Rong Jidong , Shen Changyin , Zhang Wei , Gu Ning , Chen Panke , Wang Xi , Deng Yi , Deng Chancui , Ma Shuai , Zhao Yongchao , Zhao Ranzhun , Shi Bei
Published: June 2023

Purpose
The relationship between neointimal characteristics of in-stent restenosis (ISR) and periprocedural myocardial injury (PMI) remains unclear. Therefore, this study aimed to investigate the relationship between PMI and ISR neointimal characteristics by using optical coherence tomography (OCT).
Methods
We enrolled 140 patients diagnosed with ISR with normal or stable/falling increased baseline high-sensitivity troponin T levels who underwent OCT and subsequent percutaneous coronary intervention (PCI). Patients were subdivided into with PMI (n = 53) and non-PMI (n = 87) groups based on the 4th universal definition of myocardial infarction.
Results
The prevalence of intra-intimal microvessels in patients with PMI was higher than in those without PMI (58.5% vs. 32.2%, P = 0.003). Multivariable logistic regression analysis showed that intra-intimal microvessels (odds ratio [OR], 3.431; 95% confidence interval [CI], 1.451–8.116, P = 0.005) were independently associated with PMI. Compared with patients without intra-intimal microvessels, those with intra-intimal microvessels had a higher prevalence of intima-calcification (52.5% vs. 32.4%, P = 0.030), lipid rich plaques (LRPs) (68.9% vs. 50.6%, P = 0.030) and peri-strut microvessels (65.6% vs. 16.4%, P < 0.001).
Conclusions
In patients who underwent OCT before PCI for ISR, there was a significant association between intra-intimal microvessels and occurrence of PMI. Multivariable logistic regression analysis also showed intra-intimal microvessels were independently associated with PMI.
Severity-oriented Multi-objective Crowdsourced Test Reports Prioritization
Authors: Wu Yunhuan , Xiao Lei , Liao Jingjing
Published: June 2023

Crowdsourced testing has been widely used to improve software quality since it can quickly obtain a vast number of test reports revealing various bugs. One of the most critical tasks in crowdsourced testing is determining how to inspect these valuable reports efficiently and quickly. In recent years, many automated techniques, like clustering and prioritizing, have arisen to assist in examining crowdsourced test reports. Due to the high repetition rate, most existing crowdsourced test report prioritization techniques concentrate on finding different bugs earlier while ignoring bug severity. The bug's severity reflects how detrimental the bug is to the quality of the software. In practice, developers should fix highly severe bugs as early as possible. In this paper, we propose a multi-objective prioritization technique for crowdsourced test reports that considers the diversity and severity of bugs. First, test reports are sorted in order of severity, and then the clustering results of test reports are used to adjust the first sorting sequence to ensure diversity. To acquire the clustering results, we first obtain the text feature vector and image feature vector of the test report separately, then fuse these two feature vectors. Finally, we use the density clustering algorithm to cluster the fused feature vectors. We conducted experiments on an industrial crowdsourced test report dataset from six mobile application projects to validate our method. The results show that our method can detect serious bugs earlier and different bugs faster than existing methods.
Methods for Controlling Heavy Metals in Environmental Soils Based on Artificial Neural Networks
Authors: Luo Ninglin
Published: June 2023

The problem of heavy metal pollution in soil has become a global environmental problem, and it is very important to predict and manage the heavy metals in the environmental soil in a timely manner. The changes in heavy metal content in soil have characteristics such as nonlinearity and large delay, making it difficult to predict heavy metals in soil using traditional methods. Traditional prediction methods are complex and cumbersome, which can lead to longer treatment time and easy secondary pollution. This article analyzed the Back Propagation neural network (BPNN) in artificial neural networks (ANN) and applied it to the prediction of heavy metals in environmental soils. BPNN has good nonlinear function approximation ability, so it can be well applied to complex problems such as soil heavy metal prediction. The use of BPNN can predict heavy metals in environmental soils through adaptive dynamic learning. However, the training time of the BPNN is relatively long and the convergence speed is relatively slow. Therefore, additional momentum terms were added to adjust the weights and thresholds of the network to improve the BPNN. In the experiment, the prediction performance of the improved BPNN was compared before and after the improvement. This article took 50 monitoring data of heavy metals in the same soil in a certain region in 2021 as sample data and predicted the content of heavy metals in the soil using improved and improved BPNN. Due to time constraints, this article only conducted experimental analysis on heavy metals such as lead and cadmium. The results showed that in the first experiment, when the soil sample data was 50, the prediction accuracy of the BPNN for cadmium before and after improvement was 75.95% and 89.56%, respectively. In the second experiment, when the soil sample data was 50, the prediction accuracy of the BPNN for cadmium before and after improvement was 77.99% and 89.85%, respectively. The improved BPNN has good prediction accuracy and can effectively predict the status of heavy metals in soil. The analysis in this article can provide scientific basis for the comprehensive prevention and control of heavy metals in regional soil, and also provide reference for the development of pollution-free agriculture and ensuring food safety.
Special Structures on General Rotational Surfaces in Pseudo-Euclidean 4-Space With Neutral Metric
Authors: Bejan Cornelia-Livia , Milousheva Velichka
Published: June 2023

On general rotational surfaces in the pseudo-Euclidean 4-dimensional space of neutral signature, we describe the behavior of geometric objects, such as Killing vectorfields (and in particular homothetic vector fields), divergence-free vector fields, co-closed and harmonic one-forms, and also harmonic functions. We classify geodesic and parallel vector fields, geodesic curves, concircular vector fields and concircular functions, and also concurrent vector fields and functions whose gradient is concurrent. Our results are new, as they have not been obtained in the Euclidean and Minkowski framework. The tools here are taken from both differential geometry and partial and ordinary differential equations. This topic could be of interest to many fields of mathematics, physics, engineering, architecture.
Identification of cytokine-predominant immunosuppressive class and prognostic risk signatures in glioma
Authors: Tian Ziyue , Yang Zhongyi , Jin Meng , Ding Ran , Wang Yuhan , Chai Yuying , Wu Jinpu , Yang Miao , Zhao Weimin
Published: June 2023

Purpose: The advent of immune checkpoint blockade (ICB) therapies this year has changed the way glioblastoma (GBM) is treated. Meanwhile, some patients with strong PD-L1 expression remain immune checkpoint resistant. To better understand the molecular processes that influence the immune environment, there is an urgent need to characterize the immunosuppressive tumor microenvironment and identify biomarkers to predict patient survival outcomes.
Patients and methods: Our study analyzed RNA-sequencing data from 178 GBM samples. Their unique gene expression patterns in the tumor microenvironment were analyzed by an unsupervised clustering algorithm. Through these expression patterns, a panel of T-cell exhaustion signatures, immunosuppressive cells, and clinical features correlates with immunotherapy response. The presence or absence of immune status and prognostic signatures was then validated with the test dataset.
Results: 38.2% of GBM patients showed increased expression of anti-inflammatory cytokines, significant enrichment of T cell exhaustion signals, higher proportion of immunosuppressive cells (macrophages and CD4 regulatory T cells) and nine inhibitory checkpoints (CTLA4, PDCD1, LAG3, BTLA, TIGIT, HAVCR2, IDO1, SIGLEC7, and VISTA). The immunodepleted class (IDC) was used to classify these immunocompromised individuals. Despite the high density of tumor-infiltrating lymphocytes shown by IDC, such patients have a poor prognosis. Although PD-L1 was highly expressed in IDC, it suggested that there might be ICB resistance. There are many IDC predictive signatures to discover.
Conclusion: PD-1 is strongly expressed in a novel immunosuppressive class of GBM, but this cluster may be resistant to ICB therapy. A comprehensive description of this drug-resistant tumor microenvironment could provide new insights into drug resistance mechanisms and improved immunotherapy techniques.
An anoikis-based gene signature for predicting prognosis in malignant pleural mesothelioma and revealing immune infiltration
Authors: Shi Jiaxin , Peng Bo , Zhou Xiang , Wang Chenghao , Xu Ran , Lu Tong , Chang Xiaoyan , Shen Zhiping , Wang Kaiyu , Xu Chengyu , Zhang Linyou
Published: June 2023

Introduction: Malignant pleural mesothelioma (MPM) is an aggressive, treatment-resistant tumor. Anoikis is a particular type of programmed apoptosis brought on by the separation of cell-cell or extracellular matrix (ECM). Anoikis has been recognized as a crucial element in the development of tumors. However, few studies have comprehensively examined the role of anoikis-related genes (ARGs) in malignant mesothelioma.
Methods: ARGs were gathered from the GeneCard database and the Harmonizome portals. We obtained differentially expressed genes (DEGs) using the GEO database. Univariate Cox regression analysis, and the least absolute shrinkage and selection operator (LASSO) algorithm were utilized to select ARGs associated with the prognosis of MPM. We then developed a risk model, and time-dependent receiver operating characteristic (ROC) analysis and calibration curves were employed to confirm the ability of the model. The patients were divided into various subgroups using consensus clustering analysis. Based on the median risk score, patients were divided into low- and high-risk groups. Functional analysis and immune cell infiltration analysis were conducted to estimate molecular mechanisms and the immune infiltration landscape of patients. Lastly, drug sensitivity analysis and tumor microenvironment landscape were further explored.
Results: A novel risk model was constructed based on the six ARGs. The patients were successfully divided into two subgroups by consensus clustering analysis, with a striking difference in the prognosis and landscape of immune infiltration. The Kaplan-Meier survival analysis indicated that the OS rate of the low-risk group was significantly higher than the high-risk group. Functional analysis, immune cell infiltration analysis, and drug sensitivity analysis showed that high- and low-risk groups had different immune statuses and drug sensitivity.
Conclusions: In summary, we developed a novel risk model to predict MPM prognosis based on six selected ARGs, which could broaden comprehension of personalized and precise therapy approaches for MPM.
Analogue of Ramanujan's function k(τ) for the continued fraction of order six
Authors: Guadalupe Russelle , Aricheta Victor Manuel
Published: June 2023

We study the modularity of the function w(τ ) = X(τ )X(3τ ), where X(τ ) is the continued fraction of order six introduced by Vasuki, Bhaskar and Sharath (2010). The function w(τ ) is an analogue of Ramanujan’s function k(τ ) = r(τ )r(2τ ) 2 , where r(τ ) is the RogersRamanujan continued fraction. We prove that w(τ ) is an η-quotient that generates the field of all modular functions on the congruence subgroup Γ0(18), and express X(τ ) and X(3τ ) in terms of w(τ ). We also show that there is a modular equation for w(τ ) of any level, and provide explicitly the modular equations of level p for primes p ≤ 13. We finally show that w( τ 3 ) generates the ray class field K(3) over an imaginary quadratic field K modulo 3 for some suitable τ ∈ K.
Media formulation for cellulase mediated biotransformation of cellulose from wood sawdust waste: Screening, Extracellular production and Optimization of cellulase from a newly isolated Fungal strain C-2 for prospective industrial use
Authors: Bibi Zainab , Khan Sehar , Aslam Huroom
Published: June 2023

Microorganisms populate the most extreme environments due to their incredible capacities of adaptation and biotransformation, based on a genetic potential and biosynthetic pathways of a great diversity. Industrial or agricultural residues are generated in large quantity all over the world and contribute to the global pollution of our biosphere. The current study implies the recycling and the valorization of agro-industrial carbon wastes to produce industrially valuable extracellular cellulase from a newly isolated fungal strain C-2. Cellulase has numerous applications in various food based bioprocesses such as fruit juices clarification and synthesis of single cell protein, glucose syrup, bioethanol and confectioneries. In the present study, fungal strain C-2 extracellularly released high quantity of cellulase at 30°C and pH-03 after 120 min. Among various agro-industrial wastes, 0.2% wood sawdust proved best inducer for cellulase production. It was noticed that the production of cellulase increased when 0.1% yeast extract and ammonium sulfate were used as nitrogen sources. The productivity of cellulase significantly improved after the addition of 0.1% dihydrogen potassium phosphate, 0.2% sodium chloride, 0.002% iron sulfate and 0.02% magnesium sulfate in fermentation medium. It is evident from this study that the newly synthesized cellulase from fungal strain C-2 can be exploited to meet the increasing demand of various industries.
Aggressive surgical intervention may improve prognosis in patients with ovarian metastasis from colorectal cancer
Authors: Nomura Masatoshi , Tei Mitsuyoshi , Nishida Kentaro , Mori Soichiro , Yasuyama Akinobu , Yoshikawa Yukihiro , Tamai Koki , Hamakawa Takuya , Takiuchi Daisuke , Tsujie Masanori , Akamaru Yusuke
Published: June 2023

Purpose: The current study aimed to investigate the prognostic clinicopathological factors of synchronous and metachronous ovarian metastasis (OM) from colorectal cancer (CRC) in patients with and without oophorectomy.
Methods: Female patients with OM from CRC who underwent primary tumor resection at our institution from January 2013 to December 2020 were evaluated.
Results: Of 661 female patients, 22 (3.3%) were diagnosed with OM. Among 22 patients with OM, 12 underwent OM resection. Twenty (91%) patients had extra OM upon diagnosis. Thirteen (59%) patients in the non-surgery group had peritoneal dissemination at surgery or on computed tomography scan or positron emission tomography-computed tomography. Two patients in the OM surgery group had emergency surgery because of abdominal pain. Four patients had postoperative complications, and the median duration of hospital admission was 16.5 days. The median survival time from OM diagnosis to mortality was 20.9 months. Then, the association between the clinicopathological factors and overall survival (OS) was investigated. Tumor location and surgery were found to be related to OS (p = 0.03, 0.006, respectively) in the univariate analysis. However, only surgery was associated with OS (p = 0.02) in the multivariate analysis.
Conclusion: Surgery is an important prognostic clinicopathological factor of OM from CRC. OM tumors should be resected because OM surgery is less likely to cause complications and symptoms.
Reversible Medical Image Watermarking for ROI-Based Tamper Detection and Recovery
Authors: Arham Aulia , Nugroho Hanung Adi , Adji Teguh Bharata
Published: June 2023

Medical image watermarking has become a widely studied topic in recent years. The method used to embed data into medical images must be reversible becouse tampered in medical images caused by irreversible embedding can lead to inaccurate diagnosis. Medical image watermark- ing should be able to identify the tampered area and recover it. This research work introduced a method for reversible watermarking of med- ical images. This method can embed data, detect any tampering that occurs, locate the area that has been tampered with, and then recov- ery that area of tampered in the medical image. The medical image is segmented into three sections. The first is the region of interest (ROI) for reversible embedding of patient records. The second is the region of non-interest (RONI) for reversible embedding of localization data for tampered and recovery areas. The third is the border area used for embedding coordinates of the selected ROI using Least Significant Bits (LSB). The proposed method has a capacity of up to 6 bpp of data and 12 % of the ROI area with very good visual quality of up to 50.86 dB. The watermarked image, when extracted, is identical from the original image except for the border area, provided that there is no tampering. If the ROI is tampered, the area of tampered can be identified and restored with results reaching up to +27.61 dB, with only a small difference in image quality -2.86 dB compared to the original image after extraction.
Kirschner Wire Prying and Leverage Technique—— A New Closed Reduction Method in the Treatment of Pediatric “Irreducible Supracondylar Humerus Fractures”
Authors: Yuan Xiao , Xin Liu , Ying Zhou , BO Ren , Jun Ye , Qiang Deng , Chi Kang
Published: June 2023

Objective This paper is aiming at introducing a new closed reduction method in the treatment of pediatric“Irreducible Supracondylar Humerus Fractures”.And making a clear definition of this type of fracture. Study design The sample of our study is the 120 cases of “Irreducible Supracondylar Humerus Fractures” treated surgically in our department. We classified them into two groups according to the methods being used in the treatment.Group 1 referred to the cases that were fixed by Closed reduction and percutaneous pinning(CRPP), while group 2 were treated by Kirschner wire prying and leverage technique combined with CRPP.Then we collected and evaluated relative data of two groups during the follow-up. Results The operative time and intraoperative fluoroscopy times of group 2 were significantly shorter than those of the group 1, and the percentage of open reduction in group 1 was significantly higher than that of group 2. Meanwhile, age, time from injury to surgery, and initial deviation of the distal fragment were the risk factors that leads to the failure of closed reduction. Conclusion We reached a conclusion that CRPP with kirschner wire prying and leverage technique is safe and effective in the treatment of “Irreducible Supracondylar Humerus Fractures”. This new method can significantly shorten the operation time, reduce the number of intraoperative fluoroscopy times, and lower the percentage of open reduction without increasing the risk of complications.
Strategi Pemasaran dalam Mengembangkan Usaha Ditinjau dari Etika Bisnis Islam (Studi Kasus Toko Sandal Ping Tulungagung)
Authors: Aprillia Katon , Rafikasari Elok Fitriani
Published: June 2023

Penelitian ini bertujuan untuk memberikan gambaran kepada masyarakat khususnya yang sedang mengembangkan usaha mengenai strategi pemasaran Toko Sandal Ping Tulungagung dalam mengembangkan usaha sehingga memiliki 7 karyawan dan 2 toko cabang. Namun demikian sebagai seorang muslim, etika bisnis sangat dibutuhkan dalam menjalankan berbagai aktivitas agar usaha yang dijalankan tidak bertentangan dengan ajaran Islam. Penelitian ini menggunakan pendekatan dan jenis penelitian deskriptif. Pengumpulan data dilakukan melalui observasi, wawancara dan dokumentasi. Analisis data dilakukan dengan mereduksi data, menyajikan data dan menarik kesimpulan. Pengecekan keabsahan penelitian melalui perpanjang keikutsertaan, triangulasi dan pemeriksaan teman sejawat.Hasil Berdasarkan penelitian, strategi pemasaran Toko Sandal Ping Tulungagung dalam mengembangkan pengembangan adalah melalui bauran pemasaran. Produk yang dijual berkualitas dan model terbaru. Harga yang digunakan mengikuti harga pasar dan mengambil keuntungan 10%. Tempatnya memilih lokasi yang strategis. Promosi melalui papan nama atau banner dan memberikan pelayanan yang baik kepada pembeli. Perkembangan usaha Toko Sandal Ping Tulungagung terlihat dari pendapatan rata-rata harian 2.500.000 di toko pusat dan 1.000.000 di setiap toko cabang. Toko ini memiliki 7 karyawan dan 3 toko yang terletak di Desa Ringinpitu, Desa Loderesan dan Desa Mojosari.Strategi pemasaran Toko Sandal Ping Tulungagung dalam mengembangkan usaha sesuai dengan etika bisnis Islam karena produk yang dijual berkualitas, memiliki daya tarik dan menghindari unsur gharar. Harga yang digunakan mengikuti harga pasar dan tidak mengambil keuntungan yang berlebihan. Tempatnya memilih lokasi yang strategis. Promosinya jelas dan sesuai dengan produk yang dijual.
PENGARUH KETEPATAN WAKTU TUNGGU PEMESANAN DALAM PENERAPAN METODE REORDER POINT TERHADAP TERCIPTANYA KELANCARAN MANAJEMEN PERSEDIAAN BAHAN BAKU DAN KEPUASAN PELANGGAN
Authors: Faizol Ahmad , Sari Nita Permata , Nur Aini Chindy Fatika , Nafiah Uliati
Published: June 2023

Artikel ini membahas tiga hal penting yang pertama mengenai penerapan konsep waktu tunggu dalam pemesanan, kedua tentang adanya pengaruh ketepatan waktudalam metode reorder point, dan ketiga adalah adanya pengaruh ketepatan waktutunggu pemesanan dalam terciptanya kelancaran manajemen persediaan bahan bakudan kepuasan pelanggan. Artikel ini merupakan jenis kajian kualitatif dengan teknikstudi pustaka atau library research. Kajian tersebut dikuatkan dengan beberapapengamatan dan dianalisis berdasarkan literatur yang sesuai dengan objek yangdikaji. Hasil kajian dalam artikel ini adalah (1) Dengan adanya konsep lead time, parapemangku kebijakan dapat mengendalikan persediaan bahan baku sehingga biayayang dikeluarkan oleh perusahaan bisa lebih ekonomis dan hal-hal yang mengarahkepada kemudharatan dapat dihindar (2) ROP dapat dilakukan dengan cara yaitumenentukan jumlah bahan atau barang selama lead time ditambah dengan satupersentase tertentu dan menentukan jumlah pemakaian bahan atau barang selama leadtime ditambah dengan persediaan pengamanan yang ditetapkan (3). Manajemen darilead time dapat menjadi faktor keunggulan kompetitif yang dapat meningkatkankepuasan pelanggan. Selain itu, juga memberikan pengaruh terhadap jumlahkeuntungan optimal karena konsumen merasa puas dengan pelayanan yang dibeikan..
IMPLEMENTASI INSTRUMEN HUKUM SHARIAH DALAM PARIWISATA HALAL
Authors: Huda Ahmad Miftachul
Published: June 2023

Artikel ini mendiskusikan tentang implementasi instrumen hukum shariah dalam pariwisata halal (tinjauan fatwa DSN MUI), yang mana bertujuan untuk mengetahui bagaimana penerapan fatwa DSN MUI berkaitan dengan hotel shariah di lapangan. Dalam artikel ini penulis memakai jenis penelitian kualitatif deskriptif yang dirasa sangat cocok untuk meninjau penerapan aturan secara mendetail, sedangkan sumber data di dapatkan dari penelusuran literatur ilmiah yang sudah memasukkan ragam tinjauan lapangan berkaitan dengan bahan diskusi. Dalam artikel ini penulis menemukan berbagai macam fakta menarik berkaitan dengan pariwisata halal, yang mana ternyata konteks ini sangat holistik dan masih sulit diterapkan di Indonesia, hal ini dikarenakan banyaknya sistem dan regulasi yang masih belum mewadahi ekosistem industri halal dari hulu sampai hilir. Inilah kenapa di lapangan banyak pelaku usaha yang cenderung lepas dari himbauan yang dilakukan oleh MUI
PAIN IN DIABETES MELLITUS AND BRONCHOSCOPY PROCEDURES: BREAKTHROUGHS IN MANAGEMENT AND CARE
Authors: Nugraha Lucas Nando
Published: June 2023

Overall, these two studies provide valuable insights into efforts to reduce pain burden in patients with diabetes mellitus and patients undergoing bronchoscopic procedures. In the context of diabetes mellitus, understanding the characteristics of pain in patients can help in better management. Meanwhile, the use of music as a non-pharmacological therapy in bronchoscopy procedures shows potential to reduce pain and anxiety in patients. However, further research is needed to gain a deeper understanding, as well as to overcome existing limitations, and provide optimal benefits for patients.
The Challenging Time for Indonesia Government Bond During Covid-19 Pandemic
Authors: Mulyono Mulyono
Published: June 2023

The Covid-19 pandemic has hit various countries and impacted the bond market. The research aimed to analyze the effect of the Covid-19 pandemic on government bond yields. The research contributed to developing a study on the influence of the Covid-19 outbreak on the bond market. Using an event study allowed observers to measure the impact of a particular event on financial securities. The method used was a differential test on a paired sample that tested the yield of government bonds before and after the announcement of the Covid-19 pandemic. The sample data used were the yields of government bonds at the end of 2019 and 2020. The research also used a selection of government bond yields in the Indonesia Bond Market Directory issued by the Indonesia Stock Exchange. The results show a significant influence of the Covid-19 pandemic on government bond yields. All government bond yields sampled decrease. The most significant decline occurs in government bonds with a maturity period of 1 to 5 years. The research concludes that the Covid-19 pandemic has had a significant effect on reducing the yield of government bonds. Hence, it is recommended that the government keep low-interest rates in the short term so that the yield on government bonds with maturity in the short term remains stable.
A társadalmi innovációk sikertényezőinek alkalmazási lehetőségei a magyarországi telemedicina fejlesztésekre
Authors: Kovács Erika , Németh Orsolya
Published: June 2023

A telemedicina volt az egyik a leggyorsabban fejlődő info-kommunikációs eszközökkel támogatott diagnosztikus, terápiás- és távfelügyeleti eljárás a pandemia alatt. Szükségszerűen, az egészségügyi szakszemélyzet nem lehetett a beteg mellett, így jelenléte online elektronikus kapcsolaton keresztül valósult meg. Lehet-e a telemedicina társadalmi innováció? Tanulmányunk célja a társadalmi innovációk (TI) hatékony bevezetésének tapasztalataiból származó tényezők azonosítása, és annak vizsgálata, hogy a telemedicina magyarországi elterjedéséhez alkalmazhatók-e. Első lépésben meghatározásra kerül, hogy mit jelent a társadalmi innováció és milyen tényezők járulnak hozzá a sikeréhez. Számos definíció közül a legtöbb kiemeli, hogy a TI társadalmi igényekre felmerülő innovatív megoldások, melyek technológiai újításokat is jelenthetnek, és társadalmi hatást váltanak ki, mely kritériumoknak megfelel a telemedicina, így a leírt sikertényezők, diffúziós elméletek is vonatkoztathatók rá. A telemedicina jelenlegi helyzetét áttekintve, javaslatot teszünk a társadalmi innovációk körében leírt lépések átültetésére a hazai telemedicina további fejlesztése érdekében, különös tekintettel az EESZT fejlesztésén kívüli feladatokra és az áthidaló intézményként működtethető Telemedicina Központ fejlesztésére.
Recent Insights into Nanoparticulate Carrier Systems of Curcumin and its Clinical
Perspective in the Management of Various Health Issues
Authors: Harwansh Ranjit K. , Yadav Mukul , Deshmukh Rohitas , Rahman Akhlaquer
Published: June 2023

Curcumin is a potent bioactive compound of Curcuma longa. Curcumin comprises a broad spectrum
of biological activities, including hepatoprotective, anticancer, antimicrobial, anti-inflammatory, antitumor, anti-
oxidant, etc. However, its low aqueous solubility, rapid excretion, and poor bioavailability restricted its therapeutic
uses. To resolve these issues, novel nano-systems have now been developed to increase the bioactivity
and bioavailability of curcumin by lowering the particle size, altering the surface, and increasing the efficacy of
its encapsulation with various nanocarriers. Nanotechnology-based treatments can broaden the outlook for individuals
with critical conditions. This article explores curcumin-based nanoparticulate carrier systems that
should be employed to overcome this natural ingredient's inherent limitations. These nanocarriers also provide
physical and chemical stability by encapsulating the drug into the core or matrix of the lipids or polymers. Nanotechnologists
developed curcumin-encapsulated various nanoparticulate systems, including solid lipidic nanoparticles,
polymeric nanoparticles, nano-structured lipid carriers, polymer conjugates, etc., to improve curcumin
bioavailability and boost the sustained release of curcumin to target cells.
Proteomic Analyses Reveal Functional Pathways and Potential Targets in
Pediatric Hydrocephalus
Authors: Ju Yiwen , Wan Zhenling , Zhang Qin , Li Si , Wang Bingshu , Qiu Jianmin , Zheng Shaojiang , Gu Shuo
Published: June 2023

Introduction:

Hydrocephalus is a common pediatric disorder of cerebral spinal fluid physiology
resulting in abnormal expansion of the cerebral ventricles. However, the underlying molecular
mechanisms remain unknown.

Materials:

We performed proteomic analyses of cerebrospinal fluid (CSF) from 7 congenital hydrocephalus
and 5 arachnoid cyst patients who underwent surgical treatment. Differentially expressed
proteins (DEPs) were identified by label-free Mass Spectrometry followed by differential expression
analysis. The GO and GSEA enrichment analysis was performed to explore the cancer hallmark pathways
and immune-related pathways affected by DEPs. Then, network analysis was applied to reveal
the location of DEPs in the human protein-protein interactions (PPIs) network. Potential drugs for hydrocephalus
were identified based on drug-target interaction.

Results:

We identified 148 up-regulated proteins and 82 down-regulated proteins, which are potential
biomarkers for clinical diagnosis of hydrocephalus and arachnoid cyst. Functional enrichment analysis
revealed that the DEPs were significantly enriched in the cancer hallmark pathways and immunerelated
pathways. In addition, network analysis uncovered that DEPs were more likely to be located in
the central regions of the human PPIs network, suggesting DEPs may be proteins that play important
roles in human PPIs. Finally, we calculated the overlap of drug targets and the DEPs based on drugtarget
interaction to identify the potential therapeutic drugs of hydrocephalus.

Conclusion:

The comprehensive proteomic analyses provided valuable resources for investigating the molecular
pathways in hydrocephalus, and uncovered potential biomarkers for clinical diagnosis and therapy.