Impaired physical function in patients with idiopathic inflammatory myopathies: results from the multicentre COVAD patient-reported e-survey
Authors: Yoshida Akira , Kim Minchul , Kuwana Masataka , Ravichandran Naveen , Makol Ashima , Sen Parikshit , Lilleker James B , Agarwal Vishwesh , Kardes Sinan , Day Jessica , Milchert Marcin , Joshi Mrudula , Gheita Tamer , Salim Babur , Velikova Tsvetelina , Edgar Gracia-Ramos Abraham , Parodis Ioannis , Selva O’Callaghan Albert , Nikiphorou Elena , Chatterjee Tulika , Tan Ai Lyn , Nune Arvind , Cavagna Lorenzo , Saavedra Miguel A , Shinjo Samuel Katsuyuki , Ziade Nelly , Knitza Johannes , Distler Oliver , Chinoy Hector , Agarwal Vikas , Aggarwal Rohit , Gupta Latika ,   COVAD Study Group, Barman Bhupen , Singh Yogesh Preet , Ranjan Rajiv , Jain Avinash , Pandya Sapan C , Pilania Rakesh Kumar , Sharma Aman , Manesh Manoj M , Gupta Vikas , Kavadichanda Chengappa G , Patro Pradeepta Sekhar , Ajmani Sajal , Phatak Sanat , Goswami Rudra Prosad , Chowdhury Abhra Chandra , Mathew Ashish Jacob , Shenoy Padnamabha , Asranna Ajay , Bommakanti Keerthi Talari , Shukla Anuj , Pandey Arun Kumar R , Chandwar Kunal , Cansu Döndü Üsküdar , Pauling John D , Wincup Chris , Del Papa Nicoletta , Sambataro Gianluca , Fabiola Atzeni , Govoni Marcello , Parisi Simone , Bocci Elena Bartoloni , Sebastiani Gian Domenico , Fusaro Enrico , Sebastiani Marco , Quartuccio Luca , Franceschini Franco , Sainaghi Pier Paolo , Orsolini Giovanni , De Angelis Rossella , Danielli Maria Giovanna , Venerito Vincenzo , Traboco Lisa S , Wibowo Suryo Anggoro Kusumo , Serrano Jorge Rojas , Torre Ignacio García-De La , Tehozol Erick Adrian Zamora , Loarce-Martos Jesús , Prieto-González Sergio , Gil-Vila Albert , Gonzalez Raquel Aranega , Nakashima Ran , Sato Shinji , Kimura Naoki , Kaneko Yuko , Tomaras Stylianos , Gromova Margarita Aleksandrovna , Aharonov Or , Hmamouchi Ihsane , Hoff Leonardo Santos , Giannini Margherita , Maurier François , Campagne Julien , Meyer Alain , Nagy-Vincze Melinda , Langguth Daman , Limaye Vidya , Needham Merrilee , Srivastav Nilesh , Hudson Marie , Landon-Cardinal Océane , Shaharir Syahrul Sazliyana , Zuleta Wilmer Gerardo Rojas , Silva José António Pereira , Fonseca João Eurico , Zimba Olena 
Published: August 2022

Objectives

The assessment of physical function is fundamental in the management of patients with idiopathic inflammatory myopathies (IIMs). We aimed to investigate the physical function of patients with IIMs compared with those with non-IIM autoimmune rheumatic diseases (AIRDs) utilizing Patient-Reported Outcome Measurement Information System (PROMIS) Physical Function (PF) data obtained in the COVAD study, an international self-reported e-survey assessing the safety of COVID-19 vaccines in AIRDs.

Methods

Demographics, AIRD diagnosis, disease activity, and PROMIS PF short form-10a data were extracted from the COVAD database. PROMIS PF-10a scores were compared between disease categories and stratified by disease activity. Factors affecting PROMIS PF-10a scores other than disease activity were identified by multivariable regression analysis in patients with inactive disease.

Results

A total of 1057 IIM patients, 3635 non-IIM AIRD patients and 3981 healthy controls (HCs) responded to the COVAD e-survey from April to August 2021. Using a binomial regression model, the predicted mean of PROMIS PF-10a scores was significantly lower in IIM patients compared with non-IIM AIRD patients or HCs [36.3 (95% CI 35.5, 37.1) vs 41.3 (95% CI 40.2, 42.5) vs 46.2 (95% CI 45.8, 46.6), P &lt; 0.001], irrespective of disease activity. The independent factors for lower PROMIS PF-10a scores in patients with inactive disease were older age, female, longer disease duration, and a diagnosis of inclusion body myositis or polymyositis.

Conclusion

Physical function is significantly impaired in IIMs compared with non-IIM AIRDs or HCs, even in patients with inactive disease. Our study highlights a critical need for better strategies to minimize functional disability in patients with IIMs.