bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental basis for the topical application of angiotensin-convertingenzyme inhibitor as an anti-ischemic drug in experimental eye ischemia
Authors:   Helmholtz Moscow Research Institute of Eye Diseases of Ministry of Health of the Russian Federation, Moscow,Russian Federation, Lisovskaya O.A. , Pavlenko T.A. ,   Helmholtz Moscow Research Institute of Eye Diseases of Ministry of Health of the Russian Federation, Moscow,Russian Federation, Beznos O.V. ,   Helmholtz Moscow Research Institute of Eye Diseases of Ministry of Health of the Russian Federation, Moscow,Russian Federation, Chesnokova N.B. ,   Helmholtz Moscow Research Institute of Eye Diseases of Ministry of Health of the Russian Federation, Moscow,Russian Federation, Kost O.A. ,   M.V. Lomonosov Moscow State University , faculty of chemistry, Russian Federation, Binevsky P.V. ,   M.V. Lomonosov Moscow State University , faculty of chemistry, Russian Federation, Grigorev A.V. ,   Helmholtz Moscow Research Institute of Eye Diseases of Ministry of Health of the Russian Federation, Moscow,Russian Federation
Published: December 2020

Актуальность. Перспективным направлением в терапии ишемических процессов является фармакологическая регуляция ренин-ангиотензиновая система (РАС), а также изучение возможности восстановления нарушенной гемодинамики глаза путем местного применения ингибиторов ангиотензин-превращающего фермента (АПФ). Цель. Изучить возможность восстановления нарушенной гемодинамики глаза путем местного применения ингибиторов АПФ. Материал и методы. В работе было задействовано 15 кроликов. Для создания экспериментальной модели ишемии глаза кроликам проводили субконъюнктивальную инъекцию в каждый глаз по 0,2 мл сосудосуживающего препарата Мезатон. Для количественной оценки степени ишемии применяли метод офтальмоплетизмографии (ОПГ).Проводили однократную инстилляцию раствора эналаприлата (1,25мг/мл) в OD -опытный глаз, в контрольный глаз (OS) - фосфатный буфер. ОПГ на всех этапах эксперимента проводили одновременно на обоих глазах животных до субконъюктивальной инъекции и каждые 60 мин после, в течение 180 мин. Осуществляли взятие внутриглазной жидкости (ВГЖ) из передней камеры обоих глаз. В образцах ВГЖ определяли уровень активности АПФ по начальным скоростям гидролиза субстрата Cbz-Phe-His-Leu. Результаты. В результате уровень минутный объем кровотока (МОК) опытного глаза под влиянием инстилляций ингибитора АПФ в интервале от 60 до 180 мин превышал значения МОК в контрольном глазу без лечения на 15-42%. Также после инстилляция эналаприлата достоверно снижаласьактивность АПФ (р<0,01) на 50% и 75% относительно контрольных значений. Выводы. Увеличение глазного кровотока на фоне ишемии и снижение активности АПФ в ВГЖ свидетельствует о противоишемическом действии ингибитора АПФ, что указывает на способность ингибитора преодолевать тканевые барьеры роговицы и оказывать влияние на локальную ренин-ангиотензиновую систему глаза.
Structural features of the scleral tissue of the eye with various forms ofglaucoma
Authors:   Russian Medical Academy of Continuous Professional Education, Moscow, Morozova J.S. , Arutyunyan L.L. ,   Russian Medical Academy of Continuous Professional Education, Moscow, Anisimova S.Y. ,   Eye center “East Sight Recovery”, Anisimov S.I. ,   Eye Diseases MGMSU them. A.I. Evdokimova, Iomdina E.N. ,   Moscow Helmholtz Research Institute of Eye Diseases
Published: December 2020

Актуальность. Структурная перестройка склеры при первичной открытоугольной глаукоме(ПОУГ) и глаукоме нормального давления (ГНД)недостаточно изучена, что приводит к поздней диагностике глаукомы. Цель. Провести структурный анализ склеральной ткани глаза при различных формах глаукомы. Материал и методы. В нашей работе мы изучили образцы склер пациентов 2-х групп: 1) пациенты с ПОУГ; 2) Пациенты с ГНД. Учитывая возрастные изменения структуры склеры, были учтены возрастные критерии. Группой контроля явились кадаверные склеры. Все пациенты были обследованы стандартными офтальмологическими методами. При помощи лабораторного метода –дифференциальной сканирующей калориметрии была определена поперечная связанность коллагена (калориметр «Phoenix DSC 204», Netzsch, Германия.) Результаты. Анализ полученных данных показал, что величины Tm, ΔHm денатурации коллагена (ДСК-термограммы) образцов склеры существенно различаются в группе контроля и у больных с ПОУГ. Медиана Tm, ΔHm в группе контроля составила Tm =64,6°C и ΔHm = 8,8. У пациентов с ПОУГ выявлены следующие параметры: с начальной стадией Tm =65,9°C и ΔHm=10,6 Дж/г сухого остатка, при развитой стадии Tm =66,5°Cи ΔHm =11,9Дж/г сухого остатка, при далеко зашедшей стадии Tm =67,4 °C и ΔHm =14,6Дж/г сухого остатка. У больных с ГНД медиана составилаTm =65,7°C и ΔHm =6,7. Выводы. Полученные результаты показывают повышение температуры денатурации коллагена(Tm) при ПОУГ в сравнении с группой контроля, что свидетельствует о связи повышения образования поперечных связей коллагена с развитием и прогрессированием глаукомного процесса. Повышение температуры денатурации коллагена (Tm)также отмечается у пациентов с ГНД. Нами не было выявлено статистически значимой разницы у пациентов с ПОУГ и ГНД, что объясняется малым количеством образцов и требует дальнейшего изучения.
Alteration of activity of alpha-2-macroglobulin in lachrymal liquid ofpatients with Parkinson’s disease
Authors:   Helmholtz National Medical Research Center of Eye Diseases, Moscow, Ogorodnik V.S. , Chesnokova N.B. ,   Helmholtz National Medical Research Center of Eye Diseases, Moscow, Nodel M.R. ,   Helmholtz National Medical Research Center of Eye Diseases, Moscow, Pavlenko T.A. ,   Helmholtz National Medical Research Center of Eye Diseases, Moscow, Beznos O.V. ,   Helmholtz National Medical Research Center of Eye Diseases, Moscow
Published: December 2020

Актуальность. В последние годы наблюдается рост нейродегенеративных заболеваний (НДЗ), в том числе болезнь Паркинсона (БП), в связи с увеличением продолжительности жизни, ухудшением экологии и т.д. На данный момент актуальна разработка ранней (доклинической) диагностики БП– задолго до появления моторных симптомов, что позволило бы использовать нейропротекторную терапию, направленную на замедление или даже остановку нейродегенерации. Имеются сведения об участии в формировании телец Леви при БП высокомолекулярного гликопротеина альфа-2-макроглобулина (А2МГ). Данный белок контролирует развитие воспаления, является ингибитором протеиназ, взаимодействует с цитокинами, обладает шаперонной активностью. Цель. Выявить изменение активности А2МГ вслезе, как локального биомаркера ранней диагностики БП. Материал и методы. У 19 пациентов (12 с лечением и 7 без лечения) и 16 здоровых добровольцев проводили сбор слезы в утреннее время, а также фиксировали признаки конъюнктивита, блефарита, слезотечение, сухость глаз. В слезной жидкости определяли активность комплекса А2МГ стрипсином по отношению к синтетическому низкомолекулярному субстрату N-бензоил – DL-аргинин-п-нитроанилиду (БАПНА). Результаты. Выявлено повышение активности А2МГ в слезе у пациентов с БП (без лечения23,8±0,3 нмоль/мин*мл, p<0,007, после лечения19,4±2,3 нмоль/мин*мл, р<0,008). Обнаружена значительная разница активности А2МГ между парными глазами у всех пациентов с БП без лечения16,6±4,2 нмоль/мин*мл, p<0,02 по сравнению с нормой. После лечения препаратами, направленными на восполнение недостаточности дофаминергической системы, у пациентов с БП наблюдалась тенденция к локальной нормализации активностиА2МГ (разница активности α2-МГ между парными глазами составляла 8,6±2,4 нмоль/мин*мл, p<0,05по сравнению с пациентами до начала лечения).Корреляция офтальмологических симптомов (сухость глаз, слезотечение, гиперемия конъюнктивы, блефарит) с активностью А2МГ в слезе у пациентов с БП не обнаружена. Выводы. Полученные данные подтверждают возможность использования показателя активности α2-МГ в слезе как биомаркера для ранней диагностики БП и оценки эффективности лечения.
The TNF-α in the aqueous humour of the anterior chamber dependingon the hypertonic disease presence
Authors:   State educational organization of higher professional education «Donetsk national Medical University M. Gorky», Shevchenko V.S. , Prilutskii A.S. ,   State educational organization of higher professional education «Donetsk national Medical University M. Gorky», Tkachenko K.Y. ,   State educational organization of higher professional education «Donetsk national Medical University M. Gorky»
Published: December 2020

Актуальность. TNF-α является провоспалительным цитокином, имеющим широкий спектр патофизиологических эффектов. В норме, в кровиTNF-α находится в минимальных концентрациях, однако при воспалительных (аутоиммунных и др.)процессах резко возрастает. Вместе с тем данные об изменениях уровня TNF-α во влаге передней камеры глаза при различных заболеваниях немногочисленны. Практически единичны они при возрастной катаракте. При этом исследования концентрации данного цитокина у лиц с вышеуказанной патологией в зависимости от наличия сопутствующей гипертонической болезни (ГБ) отсутствуют. Следует отметить, что TNF-α участвует в патогенезе ГБ и концентрация его в крови может иметь корреляцию со степенью её. Цель. Изучение уровня TNF-α во влаге передней камеры глаза у пациентов с возрастной катарактой в зависимости от наличия ГБ. Материал и методы. Из 68 пациентов с возрастной катарактой был отобран 21 пациент с отсутствием сопутствующих выраженных аутоиммунных и воспалительных заболеваний. Кроме того, у выбранных больных в анамнезе отсутствовали прочие заболевания глаз (увеит, глаукома и др.). Пациенты были госпитализированы для планового оперативного лечения по поводу катаракты. У 11 из данных лиц гипертоническая болезнь отсутствовала. 2-я стадия ГБ была диагностирована у10 пациентов. Влага передней камеры глаза для исследования забиралась у пациентов во время факоэмульсификации катаракты. Исследование TNF-αпроводилось с помощью разработанных нами иммуноферментных тест-систем. Результаты. Результаты исследований показали, что уровень фактора некроза опухоли-альфа во влаге передней камеры глаза у пациентов со 2стадией ГБ был существенно выше (p=0,025), чему пациентов с катарактой без данной сопутствующей патологии. Выводы. Показано достоверное увеличение концентрации TNF-α у лиц с катарактой в сочетании со 2 стадией гипертонической болезни. Полученные данные следует учитывать, как при проведении лечебной работы так и при осуществлении научных исследований.
Reasons for completion of anti-vegf therapy of neovascular macular diseases:results of the patients ‘survey (preliminary report)
Authors:   Ural State Medical University, Department of Ophthalmology, Yekaterinburg, Russian Federation, Beresneva N.S. , Bobykin E.V. ,   Ural State Medical University, Department of Ophthalmology, Yekaterinburg, Russian Federation
Published: December 2020

Актуальность. Анти-VEGF терапия (от англ.vascular endothelial growth factor, VEGF – фактор роста эндотелия сосудов) является «золотым стандартом» лечения таких социально-значимых заболеваний макулы, как неоваскулярная («влажная»)возрастная макулярная дегенерация (вВМД), диабетический макулярный отёк (ДМО), макулярный отёк вследствие окклюзии вен сетчатки (МООВС)и миопическая хориоидальная неоваскуляризация (мХНВ). Длительное регулярное наблюдение имеет решающее значение для достижения и сохранения функционального эффекта терапии. Цель. Изучить причины, побудившие пациентов, получавших анти-VEGF терапию заболеваний макулы в условиях реальной клинической практики, прекратить наблюдение в клинике. Материал и методы. Исследуемую группу составили 214 пациентов (из них женщин – 131; 61,2%) ввозрасте от 24 до 92 лет (в среднем 68,7±13,3), получавших анти-VEGF терапию (ранибизумаб, афлиберцепт) по поводу ВМД (151 случай; 70,1%), МООВС (24; 11,2%), мХНВ (20; 9,3%), ДМО (19; 8,9%).Все пациенты прекратили лечение в клинике: не явились на очередной осмотр, а также в течение двух месяцев после него. Для установления причин прекращения наблюдения и определения фактического статуса последующего лечения был проведён телефонный опрос с использованием анкеты, предложенной Boulanger-Scemama E. с соавт. в 2015 году. Результаты. Выявлены следующие категории пациентов (n=214), завершивших анти-VEGF терапию в клинике: полное прекращение лечения –120 (56,1%), смена клиники - 20 (9,3%), смерть – 23(10,7%); не удалось установить статус 51 (23,8%)человека. Наиболее частыми причинами прекращения антиангиогенной терапии (n=120) стали неудовлетворённость результатами лечения (59 случаев; 49,2%), финансовое бремя (49; 40,8%) и общие сопутствующие заболевания (24; 20,0%). Мотивами, побудившими пациентов (n=20) сменить клинику, стали: финансовое бремя (17 случаев; 85,0%), неудовлетворённость результатами лечения (5; 25,0%)и большое расстояние от дома до больницы (1;5,0%). Выводы. Возможные пути повышения приверженности пациентов анти-VEGF терапии: максимально ранняя диагностика и начало лечения; выбор наиболее эффективных препаратов и терапевтических режимов; индивидуализация лечения; организационные мероприятия, направленные на повышение доступности специализированной помощи.
Concept of Large-scale Thermomechanical URL Experiments in the Nizhnekanskiy Rock Massif
Authors:   Nuclear Safety Institute of the Russia Academy of Sciences, Moiseenko E. V. , Drobyishevsky N. I. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Butov R. A. ,   Nuclear Safety Institute of the Russian Academy of Sciences, Tokarev Yu. N. ,   Nuclear Safety Institute of the Russian Academy of Sciences
Published: December 2020

Numerical simulation of thermomechanical processes in a deep underground radioactive waste repository requires information on the host rock and the engineered barriers properties at a scale of dozens of centimeters, meters and more. However, the extrapolation of the values obtained on small-scale samples in surface laboratories yields excessive uncertainties. The materials behavior is also influenced by conditions that cannot be reliably reproduced in a surface laboratory, such as water content or initial stress-strain state. Following experiments are planned to study the host rock and the engineered barriers behavior during heating under conditions similar to those expected in the repository, as well as to assess their large-scale thermomechanical properties. In the experiment focused on the excavation damaged zone thermal mechanics, the behavior of reinforced drift walls and vaults under heating will be studied. The experimental facility will involve two drifts with the same orientation as the planned repository ones. As a result, the spatial distribution of excavation damaged zone thermomechanical parameters and their evolution due to heating will be identified. The second experiment focuses on the host rock mass behavior under spatially nonuniform unsteady heating. The facility will feature two vertical boreholes with heaters. The experiment will be divided into several stages: study of the host rock initial state, estimation of the rock main thermomechanical properties, study of the temporal evolution of the stress field due to 3D temperature gradients and of the processes in the host rock occurring during its cooling and re-saturation with water. Following the completion of the separate-effect test program, an integrated experiment should be carried out to study the coupled processes with respect to their mutual influence. The obtained results will be used to refine the values of input parameters for numerical simulations and their uncertainty ranges, as well as to validate the computer codes.
Türkiye’de 2009-2018 yılları arasında KOBİ’ler ve girişimcilik üzerine yapılan araştırmaların değerlendirilmesi
Authors: YALÇIN İbrahim , İŞCAN Yasin Murat
Published: December 2020

Bu çalışmada, Türkiye’deki akademik dünyada kobi’ler ve girişimcilik üzerinde yapılan bilimsel araştırmaların bir değerlendirmesi yapılacaktır. Çalışmada, akademik olarak Türkiye’de araştırma alanının nasıl değerlendirildiğinin anlaşılabilmesi için nitel analiz yöntemlerinden içerik analizi kullanılmıştır. 2009-2018 yılları arasında Tubitak-Ulakbim veri tabanı sosyal bilimler alanında dergi ve makale başlığında “KOBİ” veya “Girişimcilik” kelimeleri 311 adet makale ve 2 adet dergiye ulaşılarak MAXQDA 2018 programıyla değerlendirmeler yapılmıştır.
Assessment of growth status by correlating he maturation stages of middle phalanx of the third finger and calcification stages of mandibular third molar in an institutional set up
Authors: Reshma Mohan  , Ravindra Kumar Jain  , Nivethigaa Balakrishnan
Published: December 2020

The present study aims to assess the correlation between maturation stages of the middle phalanx of the third finger and calcification stages mandibular of the third molar in 9-16 years old children in the South Indian population. A total of 39 subjects between the age of 9-16 years were included for this study. Their pretreatment digital panoramic and hand-wrist radiographs were retrieved from the DIAS software provided by Saveetha Dental College and Hospital, Chennai, TamilNadu, India. These records were analyzed with the help of Demirjian index, used for mandibular third molar maturation stage, and Modified MP3 method, used for Middle phalanx maturation stage. Pearson's Chi-Square tests were done to analyze the association between Mp3 stages and mandibular third molar calcification stages. The statistical tests were performed in SPSS software. The results of this study showed that there is a statistically significant association between Demirjian index and modified MP3 stages in both females (p<0.002) and males (p<0.000). Within the limitations of this study, it was concluded that calcification stages of the lower third molar could be used as a supportive tool to assess maturation. As third molars are known to have many alterations, individual variation should be taken under consideration.
Pengaruh Gaya Kepemimpinan, Budaya Organisasi dan Komitmen Organisasi Terhadap Kinerja Pegawai Dinas Pertanian Kabupaten Mamuju
Authors: Sari Dewi Andi Ratna , Hasniaty,S.E.,M.Si Dr.
Published: December 2020

Penelitian ini bertujuan dan menganalisis pengaruh budaya organisasi dan komitmen organisasi terhadap kinerja pegawai Dinas Pertanian Kabupaten Mamuju dan untuk mengetahui variabel yang paling dominan berpengaruh terhadap kinerja pegawai Dinas Pertanian Kabupaten Mamuju. Dalam penelitian ini yang menjadi populasi adalah seluruh pegawai Dinas Pertanian Kabupaten Mamuju pada tahun 2017 yaitu berjumlah 35 pegawai. Hasil penelitian menunjukkan bahwa variabel gaya kepemimpinan, budaya organisasi dan komitmen organisasi secara bersama-sama berpengaruh secara positif dan signifikan terhadap kinerja pegawai Dinas Pertanian Kabupaten Mamuju. Hasil analisis menunjukkan bahwa dari ketiga variabel yang diteliti, variabel komitmen organisasi mempunyai pengaruh paling dominan terhadap kinerja pegawai Dinas Pertanian Kabupaten Mamuju.Kata Kunci :Gaya Kepemimpinan, Budaya Organisasi, Komitmen Organisasi, Kinerja
FINANCIAL PERFORMANCE AND EFFECTIVENESS ON DEBT MANAGEMENT IN STATE-OWNED ENTERPRISE PHARMACEUTICAL SECTOR PERIOD 2004 - 2016
Authors: Angreyani Andi Dewi
Published: December 2020

This study aims to determine the effect of financial performance, effectiveness, corporate growth on debt management in state-owned enterprises in the pharmaceutical sector period 2004 to 2016.The object of this research is state-owned pharmaceutical company. Financial performance with ROI, ROE and NPM as indicator, effectiveness with CR as indicator and company growth (GROWTH as indicator) is independent variable, while debt management with DAR as indicator. The sampling technique used is purposive sampling with audited financial statement criteria and published from 2004 to 2016 and has a book year ended on 31 December. Earned 39 samples from 3 state-owned enterprises Pharmaceutical Sector.Data analysis techniques using PLS-SEM by testing outer and inner. Data is then processed with SmartPLS 3.0 software.The results obtained are the financial performance and effectiveness have a positive and significant influence on debt management while the growth of the company has no positive and significant influence on the management of debt in state-owned pharmaceutical secktor company. Keywords: Financial Performance, Effectiveness, Corporate Growth Profit Growth, Debt Management.
GESTIÓN DE SIMPLIFICACIÓN ADMINISTRATIVA EN EL DESARROLLO DE LAS UNIVERSIDADES PÚBLICAS
Authors: Junior Silva Huamantumba Edman Junior
Published: December 2020

La investigación se realizó con el objetivo de conocer las características de la gestión de simplificación administrativa en el desarrollo de las Universidades públicas. La investigación es descriptiva, con enfoque cualitativo. La muestra estuvo conformada por artículos científicos; como técnica se usó el análisis bibliográfico y como instrumentos la guía de análisis de revisión bibliográfico, haciendo uso del método deductivo. Teniendo como resultados que el 70% hace referencia a la simplificación administrativa que está basada en procesos de tiempo en brindar el servicio, procesos administrativos y costos. El 30%, menciona que la gestión de simplificación administrativa debe aplicar tecnología virtual que parte desde políticas internas institucionales con miras a mejorar los servicios con trámites accesibles y menos costosos, generando desarrollo a las instituciones gubernamentales. Concluyendo que la simplificación administrativa debe estar acompañada de tecnología, con programas que faciliten los procesos en menos tiempo, disminuyendo trámites, carga documental administrativa y los costos, para generar desarrollo en la institución. Además, la simplificación administrativa en las instituciones públicas es un requisito primordial para mejorar su competitividad; sin embargo, se necesitan mejorar los procesos de simplificación, con trámites menos burocráticos y servicios oportunos al ciudadano.
Institucionalização das políticas informadas por evidências no Brasil
Authors: de Oliveira Sandra Maria do Valle Leone , Bento Andressa de Lucca , Valdes Gabriel , de Oliveira aú Tavares Pereira , de Souza Albert Schiaveto , Barreto Jorge Otávio Maia
Published: December 2020

Objetivo.Avaliar capacidades, arranjos organizativos e barreiras à implementação dos Núcleos de Evidências (NEvs) da Rede de Políticas Informadas por Evidências (EVIPNet) no Brasil.

Métodos.Realizou-se um estudo exploratório de casos múltiplos, descritivo-analítico, com abordagem mista. Os coordenadores dos NEvs em atividade no país responderam um instrumento com três partes: caracterização do respondente, avaliação da capacidade de “adquirir, avaliar, adaptar e aplicar” evidências (4A) e questões abertas abordando arranjos organizativos e barreiras à implementação dos NEvs.

Resultados.Participaram da pesquisa 15 NEvs, concentrados no Centro-Oeste; 73,3% estavam sediados em universidades e 20% em secretarias estaduais/municipais ou no Ministério da Saúde. Dos coordenadores participantes, 100% possuíam pós-graduaçãolato e/ou strictu sensue 80% referiram experiência de 1 a 5 anos em políticas informadas por evidências (PIE) e proficiência em inglês. Nenhum coordenador atuava exclusivamente no NEv. As equipes incluíam profissionais de saúde, estudantes (graduação/pós-graduação), docentes de universidades e servidores efetivos em secretarias de saúde. Foram identificadas alta capacidade para “adquirir” e “avaliar” e baixa capacidade para “adaptar” e “aplicar” evidências. Quanto a atividades e produtos, prevaleceu a média de três por ano, com destaque para produtos de tradução do conhecimento (sínteses de evidência e diálogos deliberativos) e capacitação para profissionais de saúde, gestores e alunos de graduação/pós-graduação. Cinco categorias de barreiras foram descritas: 1) financiamento, 2) integração da rede, 3) institucionalização das demandas, 4) capacidade de adaptação e 5) habilidades de comunicação de pesquisa para recomendar ações no nível local.

Conclusões.Existem recursos humanos capacitados, vinculados a instituições de pesquisa e ensino, para apoiar as PIE. No entanto, a sustentabilidade dos NEvs depende de ações coordenadas para garantir a capacidade de adaptar e aplicar evidências.
Karakteristik Kepribadian Antisosial
Authors: Kusuma Annisa Dwianggreni , Sativa Shania Ocha
Published: December 2020

Secara epidemiologi gangguan kepribadian antisosial ditemukan sebanyak 2-4 % pada laki-laki dan 0.5-1% pada wanita. Prevalensi usia puncak ditemukannya kepribadian ini pada 24-44 tahun. Penegakkan diagnosis kepribadian ini dapat menggunakan PPDGJ III dan DSM-V. Metode yang digunakan dalam penelitian ini adalah studi literature review. Sumber pustaka yang digunakan dalam menyusun literatur ini terdiri dari buku pedoman, jurnal nasional, jurnal internasional, maupun website. Penelusuran sumber pustaka dilakukan melalui akses data NCBI dan Google Scholar terkait karakteristik kepribadian antisosial. Sumber pustaka yang digunakan terdiri dari 15 pustaka yang ditulis mulai dari tahun 1999 hingga 2019. Hasil penelitian menunjukkan gangguan kepribadian antisosial sering terjadi pada laki-laki di lingkungan penjara dan adanya abnormalitas pada grey matter lobus parietal otak dan white matter lobus oksipital. Simpulan gangguan kepribadian antisosial yaitu terlihat berkarisma, memiliki riwayat hidup dalam hal kriminal, tidak ada waham, pikiran tidak rasional, mudah menjebak orang terlihat dalam aktivitasnya dan khasnya yaitu tidak adanya penyesalan terhadap perbuatannya dikarenakan kurangnya kontrol empati dan perasaan terhadap orang lain. Kata kunci: kepribadian antisosial, penegakkan diagnosis, prevalensi CHARACTERISTIC OF ANTISOSIAL PERSONALITY ABSTRACTEpidemiologically antisocial personality disorder is found as much as 2-4% in men and 0.5-1% in women. The peak age prevalence for this personality is found in 24-44 years. The management of this personality diagnosis can use PPDGJ III and DSM-V. The method used in this research is the literature review study. The method used is a literature review that was taken from a guidebook, national journals, international journals, and website. The literature consists of 15 library sources which are traced through NCBI aand Google Scholar data access. Literature Sources used were written in 1999 to 2019. The results showed antisocial personality disorder often occurs in men in prison environments and abnormalities in gray matter parietal lobes of the brain and white matter in the occipital lobe. Conclusions of antisocial personality disorder that is seen to be charismatic, have a history of life in criminal matters, no misunderstanding, irrational thoughts, easy to trap people seen in their activities and typically that there is no remorse for their actions due to lack of empathy control and feelings towards others. Keywords: antisocial personality, diagnosis,  prevalence
Application of Therapeutic Therapy Therapies in Improving Baby Motor Development
Authors: Oktaviana Wita , Keliat Budi Anna
Published: December 2020

Infancy is the starting point according to the capabilities and abilities that are formed. The age of the baby has a developmental task that must be questioned, namely trust and suspicion, which is not fulfilled so that it can cause fear there will be no comfort from the environment so that this baby develops suspicion for others and does not trust other people as well. Therapeutic group therapy (TKT) is one type of therapy that helps complete the development of infants, one of which is the development of motor skills. The purpose of reporting this case is to further resolve the application of TKT in improving infant motor development. The method used in this scientific work is a case report. The intervention was carried out on six family that has babies 0-6 months with a priority nursing diagnosis that is enforced is the readiness to increase the infant's age. Interventions were carried out in groups where each group consisted of 6-10 people. Improving the ability of infants through discussion and interviews after the intervention is carried out. The interventions given were generalist therapy and therapeutic group therapy (TKT). The author uses a workbook and a therapeutic evaluation book for Therapeutic Groups (TKT) to determine the understanding of baby's abilities. The results obtained are group therapy that can provide increased motor skills in infants.
Adolescents' Attitude Towards Premarital Sex
Authors: Anggiani Violla , Hernawaty Taty , Widianti Efri
Published: December 2020

Pangandaran is a tourism place given more impact on behavior sexuality among adolescents. One of the factors that most influence this behavior is attitude. The attitude becomes a stimulus for adolescents in reflecting premarital sexual behavior. This research aimed to find out the adolescent's attitudes towards premarital sexual behavior in SMA X Pangandaran. This research used a descriptive quantitative method with a cross-sectional approach. The study population was adolescents at SMA X Pangandaran with a total of 842 people. The data collection used proportionate stratified random sampling, with the sample counted as 240 students. Data were collected within 2 weeks using BSAS which was distributed online and the validity test was carried out with a score of 0.896 and a reliability test with an Alpha value of 0.861. Data were analyzed by the mean and standard deviation formulas. In this study, adolescent attitudes toward premarital sexual behavior tend to be less accepting about sex (permissiveness) 43,40 ± 5,772, responsible for birth control 11,14 ± 2,820, do not tend to fuse with sex partners (communion) 14, 96 ± 4.892, and do not tend sexual orientation (instrumentality) 18.36 ± 4.007. The majority of students consider premarital sex is not allowed and is a taboo subject to talk about.
Is the Spiritual Intelligence of Parents Related to Youth's Emotional Status and Sexual Behavior?
Authors: Darmawan Ardhian Indra , Huriah Titih
Published: December 2020

Related Research spiritual intelligence of parents with emosioal status and sexual behavior of teenagers. The purpose of knowing the relationship of sexual behavior and emotional status of adolescents with the spiritual intelligence of parents in work area Puskesmas Kasihan I. This study used a mix method design with sequential explanatory. Quantitative respondents were 132 adolescents and parents. Analysis of the data used in this quantitative study was control tau. The qualitative participants were 11 teenagers. Research interviews were conducted on 11 student participants who were taken by purposive sampling and qualitative data analysis using invivo software. The instrument used was the Spiritual Self-Report Inventory (SISRI), Strengths and Difficulties Questionnaire (SDQ), Sexual Behavior. Qualitative instruments use interview guides, telephone and observation sheets. The results showed that 101 adolescents with abnormal emotional status, 15 boderlines, 4 normal respondents. Adolescent sexual behaviors that are positive or active are 44 teenagers and 89 adolescents are negative or inactive behaviors. Found three factors that influence the emotional status and sexual behavior of adolescents, namely the role of moral education from parents, social control and adolescent self-control ability. The role of parents, the environment and adolescent self control affect the emotional status and sexual behavior of adolescents.
TEXT-TABLES AS A MEANS OF TEACHING MEDICAL UNIVERSITY STUDENTS PROFESSION ORIENTED COMMUNICATION IN A FOREIGN LANGUAGE
Authors: Gukina L. V.
Published: December 2020

The article concerns text-tables as means of developing critical thinking in medical university students learning advanced English of medicine. Text-tables are shown to be effective in promoting situational profession oriented communication of students in small and large groups in class.
USING A CONTEXTUAL-COMMUNICATIVE APPROACH IN PREPARING FUTURE MANAGERS FOR INTERCULTURAL COMMUNICATION
Authors: Kuteneva I. E.
Published: December 2020

The article gives definitions of concepts: context, professional context, contextual learning, communicative approach, manager, management and intercultural communication. The classification of contexts is given. Types of professional context are indicated. The idea and principles of contextual learning are described. The basic unit of the content of education and the basic unit of student activity in contextual learning are considered. The implementation order and the idea of contextual learning are indicated. Learning models are listed. The requirements of contextual learning are described. The purpose of the communicative approach is indicated. A brief historiography of the communicative approach is considered. The main task, principles and advantage of the communicative approach are described. The points of genuine communicativeness in language teaching and the principles of a communicative approach are considered. The functions and roles of the manager in the organization are described, the qualities of the manager are listed. The object and task of management are indicated.
IMPLEMENTATION OF THE LITERARY RALLY METHODOLOGY IN THE PROCESS OF FORMATION OF COMMUNICATIVE-COMPENSATIVE COMPETENCE OF STUDENTS
Authors: Lapteva E. I.
Published: December 2020

In this article are discussed the concept of communicative-compensative competence of students and the process of implementing the literary rally methodology in order to form this competence and achieve an effective communicative result.
PEDAGOGICAL SUPPORT OF FOREIGN STUDENTS` ACADEMIC ADAPTATION IN FOREIGN LANGUAGE LESSONS (KEMSU EXPERIENCE)
Authors: Kolomiets S. V.
Published: December 2020

The article presents the major aspects of the foreign students` academic adaptation in Russian universities. The necessity to elaborate pedagogical support for foreign students in the process of adaptation to the study in the Russian universities is stressed. The article describes the methods of pedagogical support of foreign students` learning employed by teachers of the Department of Foreign Languages of Kemerovo State University.
METHODOLOGICAL ANALYSIS OF THE EXISTING PRACTICE OF UNIVERSITY TRAINING IN TERMS OF GRADUATES' INTEGRATED COMPETENCIES
Authors: Strelnikov P. A.
Published: December 2020

The article presents the results of the methodological analysis of the existing practice of University training in terms of graduates' integrated competencies. The analysis was carried out at the general philosophical (system and genetic approaches), general scientific (process-effect approach), specific scientific (competence, personal-activity and situation-problem approaches) and methodological and procedural levels (integrative and interdisciplinary approaches). Systemic shortcomings that impede the educational productivity of the existing training practice in terms of the efficiency of educational integration are identified and described. The definition of educational integration is given as the process of integration of individual competencies acquired by a student in the process of mastering individual disciplines into a single system totality, which is an integral tool for the graduate's professional activity.
INVESTIGATION OF THE PROBLEMS OF LATERAL OUT LOAD OF LIQUIDS
Authors:   Bukhara Engineering Technological Institute of the Republic of Uzbekistan, Yunusov Ganisher
Published: December 2020

The paper studies the problem of the flow of an ideal incompressible fluid in the presence of outflow to the side channels
REVOLUTION SURFACES FORMED IN THE GALILEAN MOTION
Authors:   Navoi State Pedagogical Institute of the Republic of Uzbekistan, Sobirov Jasur , Sultanov Bekzod ,   National University of Uzbekistan
Published: December 2020

This article highlights the existence of surfaces, relative to the system of curvilinear coordinate, which was introduced by A. Artykbaev. Moreover, the study of revolution surfaces formed in the Galilean motion is provided. In Galileo's space, the differential characteristics of these revolution surfaces are studied, and surfaces with constant curvature and minimal ones are indicated
RESEARCH OF MODELS OF NEW PLATE HEAT-RELEASING ELEMENT
Authors:   Institute of Nuclear Physics of the Academy of Sciences of the Republic of Uzbekistan, Hikmatov Ilkhom , Kungurov Fakhrulla , Baitelesov Sapar , Tojiboev Davronbek , Alikulov Sherali , Tadjiboev Dier , Egamediev Serik
Published: December 2020

The main parameter of research reactors is the neutron flux density. To obtain high neutron fluxes, the research reactor must be compact and the reactor power must be maximized. Nuclear fuel plays the main role in high-flow research reactors. Nuclear fuel using UO2is limited by the density of uranium in fuel elements (FUEL ELEMENTS) 3 g / sm3
Efektivitas Penggunaan Model Latihan Kebugaran “Bbc Exercise” Untuk Pemeliharaan Kebugaran Jasmani Mahasiswa
Authors: Bile Robertus Lili , Suharharjana Suharharjana
Published: December 2020

ABSTRACTThe problem of physical fitness is still a global pandemic which is increasingly widespread in many circles of society. Singentari lifestyle is one of the factors causing health problems such as degenerative diseases, decreased physical fitness, injury prone, decreased cognitive function and so on. Students with a relatively high level of activity tend to ignore regular sports activities so that it has an impact on the low level of physical fitness. This study aims to test the effectiveness of using a fitness training product in the form of a “BBC Exercise” model for maintenance of physical fitness. This research was conducted at STKIP Citra Bakti Ngada, involving 15 students with an age range ≤19 years as research subjects. The research design used was a pre-experimental time series with a one group pretest-posttest design. Data were collected by measuring physical fitness using the TKJI format (Indonesian Physical Fitness Test). The results of the pretest-posttest difference test obtained the sig value. (2-tailed) paired samples t-test (0.000) is smaller than (0.05) or (p <0.05). This means that there is a significant effect of using the "BBC Exercise" model on changes in the physical fitness categories of students. Thus, it is concluded that the use of the "BBC Exercise" exercise model is proven to be "effective" in increasing physical fitness. ABSTRAKPermasalahan kebugaran jasmani hingga kini masih menjadi pandemi global yang semakin meluas pada banyak kalangan masyarakat. Pola hidup sendentari menjadi salah satu faktor penyebab timbulnya gangguan kesehatan seperti penyakit degeneratif, kebugaran jasmani menurun, rentan cedera, penurunan fungsi kognitif dan lain sebagainya. Mahasiswa dengan tingkat kesibukan yang relatif tinggi cenderung mengabaikan aktivitas olahraga reguler sehingga berdampak pada rendahnya tingkat kebugaran jasmani. Penelitian ini bertujuan untuk menguji efektivitas penggunaan sebuah produk latihan kebugaran berupa model “BBC Exercise” untuk pemeliharaan kebugaran jasmani. Penelitian ini dilakukan di STKIP Citra Bakti Ngada, melibatkan 15 mahasiswa dengan rentang usia ≤19 tahun sebagai subjek penelitian. Desain penelitian yang digunakan adalah pra-eksperimen time series dengan rancangan one group pretest-posttest. Data dikumpulkan dengan tes pengukuran kebugaran jasmani menggunakan format TKJI (Tes Kesegaran Jasmani Indonesia). Hasil uji beda pretest-posttest diperoleh nilai sig. (2-tailed) paired samples t-test (0,000) lebih kecil dari (0,05) atau (p<0,05). Hal ini berarti bahwa terdapat pengaruh yang signifikan penggunaan model “BBC Exercise” terhadap perubahan kategori kebugaran jasmani mahasiswa. Dengan demikian disimpulkan bahwa penggunaan model latihan “BBC Exercise” terbukti “Efektif” meningkatkan kebugaran jasmani.
Features of the kinetics of cyclic elastoplastic deformation diagrams at dwells in cycles and superimposition of variable stresses on them
Authors: Gadenin M. M.
Published: December 2020

The goal of the study is determination of the regularities of changes in cyclic strains and related deformation diagrams attributed to the existence of time dwells in the loading modes and imposition of additional variable stresses on them. Analysis of the obtained experimental data on the kinetics of cyclic elastoplastic deformation diagrams and their parameters revealed that in contrast to regular cyclic loading (equal in stresses), additional deformations of static and dynamic creep are developed. The results of the studys are especially relevant for assessing the cyclic strength of unique extremely loaded objects of technology, including nuclear power equipment, units of aviation and space systems, etc. The experiments were carried out on the samples of austenitic stainless steel under low-cycle loading and high temperatures of testing. Static and dynamic creep deformations arising under those loading conditions promote an increase in the range of cyclic plastic strain in each loading cycle and also stimulate an increase in the range of elastoplastic strain due to active cyclic deformation. At the same time the existence of dwells on extrema of stresses in cycles without imposition of additional variable stresses on them most strongly affects the growth of plastic strain ranges in cycles. Imposition of additional variable stresses on dwells also results in the development of creep strains, but their growth turns out to be somewhat less than in the presence of dwells without stresses imposed. The diagrams of cyclic deformation obtained in the experiments are approximated by power dependences, their kinetics being described in terms of the number of loading cycles using corresponding temperature-time functions. At the same time, it is shown that increase in the cyclic plastic deformation for cycles with dwells and imposition of additional variable stresses on them decreases low cycle fatigue life compared to regular loading without dwells at the same stress amplitudes, moreover, the higher the values of static and dynamic creep, the greater decrease in low-cycle fatigue life. This conclusion results from experimental data and analysis of conditions of damage accumulation for the considered forms of the loading cycle using the deformation criterion of reaching the limit state leading to fracture.
Conductometric comparative assessment of crop stress resistance to chemical pesticides
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Korobov V.A. , Morozov D.O. , Ivleva A.E.
Published: December 2020

Using the conductometric method in field experiments, a positive correlation was established between the relative electrical conductivity of aqueous extracts of leaves and the yield of barley and soybeans: 0.833 and 0.994. Based on the regression equations, the threshold of stress resistance of plants to pesticides was calculated, which was 30% of the deviation of the electrical conductivity of aqueous extracts from the leaves of the treated plants from the control. A comparative assessment of 12 field crops to treatments with chemical pesticides was carried out.
Valuable indicators of the quality of galega orientalis and galega officinalis Trusina L.A., PhD in Agricultural Sciences
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Trusina L.A. , Korovina V.L.
Published: December 2020

The article deals with two types of perennial leguminous plant Galega orientalis (Galega orientalis Lam.) and Galega officinalis (Galega officinalis L.), grown in the non-Chernozem zone of Russia.
In vitro propagation of sweet potato (Ipomoea batatas (L.) Lam.)
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Abubakarov H. G. , Kalashnikova E.A. , Kirakosyan R.N. , Shitikova A.V.
Published: December 2020

The results of optimizing the conditions for growing sweet potatoes in vitro are presented. It is shown that the mineral composition of the nutrient medium has a significant effect on the growth of side shoots. With the simultaneous formation of shoots, rooting of micro gears was observed.
Photosynthetic activity as the basis of potato productivity when using phytohormones
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Shitikova A.V. , Abiala A.A.
Published: December 2020

The results of studies on the role of growth biostimulants in the exogenous regulation of potato productivity on sod-podzolic soils of the Moscow region are presented.Studies have established the specificity of the action of phytohormones.The stimulating effect of the drugs manifested itself in the intensification of metabolic processes, changing the direction of biochemical reactions, which led to an increase in productivity.
Еstimation of economically useful characteristics and properties of spring barley varieties
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Dedushev I.A. , Boldyrev M.A.
Published: December 2020

the quality of spring barley varieties in various directions is evaluated by various methods. Analysis of 9 varieties in the waterlogged year 2020 in the conditions of the Moscow region allowed us to evaluate the best varieties for feed and brewing qualities. For the evaluation of feed barley, the main value is the increased content of protein and essential amino acids, including lysine. Maximum values of protein (13,06%) and lysine (0,44%) were diagnosed as grade Accounting. Brewing requires varieties with a low protein content of up to (12%) and high extractivity (80%). The Reliable variety had the best malt indicators of protein content (10.78%) and extractivity (82.5%).
Evaluation of effectiveness of bacteriophage agent for cabbage black rot control
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Orynbayev A.T. , Miroshnikov K.A. , Ignatov A.N. , Dzhalilov F.S.
Published: December 2020

Twenty-one isolates of bacteriophages specific to eleven target strains of Xanthomonas campestris pv. campestris were isolated from soil samples collected under black rot-infected cabbage plants. After the analysis of phagotyping for seventy-three phytopathogen strains against newly isolated isolates and four collection strains of bacteriophages, it was proposed to construct a phage cocktail including 6 isolates In vitro screening of protective from ultraviolet radiation substances under the UV-B range showed that skim milk (0.75%), Riboflavin (0.5%) and ascorbic acid (0.1%) showed the highest effect for bacteriophages. Under the conditions of a film greenhouse, the best protective effect from solar UV radiation on the 8th day after spraying cabbage was shown by the option with the addition of skimmed milk (0.75%) and Riboflavin (0.5%). According to our data, these substances can provide a long-term photoprotective effect of the bacteriophage preparation..
Influence of Septoria fungi on productivity and yield of winter wheat varieties with different stability in the Penza region
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Kalacheva D.Y. , Beloshapkina O.O.
Published: December 2020

The results of phytosanitary monitoring of mycoses in crops of 9 varieties of winter wheat in the Penza region on the basis of Limited liability corporations «SoyuzAgro» are presented. The prevalence of septoria infection varied in 2020 from 13 to 42%, and the development - from 1.5 to 5.5%. Varieties of different resistance were identified for production and selection for agronomically valuable traits - protein content, gluten, yield and resistance to septoria.
Agro-landscape and ecological zoning for crop and meadow production in Eastern Siberia
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Trofimova L.S. , Trofimov I. A.
Published: December 2020

The agro-landscape and ecological zoning of the East Siberian natural and economic region has been developed. A map, legend to the map, classification of natural forage lands and classification of deer pastures have been compiled. A detailed description of all 136 designated zoning units (zones, mountain territories, provinces, districts) is given.
Agricultural lands in crop and grassland of the Buryatia republic
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Yakovleva E.P. , Trofimov I. A.
Published: December 2020

The results of agrolandic and ecological zoning of the Republic of Buryatia are presented. The characteristics of natural conditions and agricultural use of lowland and mountain provinces are given. These include information on landscapes, relief, soils, vegetation, characterization of field agroecosystems, pastures and haymakings, prevalent in the provinces.