bluuebunny/crossref_metadata_2025 huggingface dataset:
X‐linked intellectual disability related genes disrupted by balanced X‐autosome translocations
Authors: Moysés‐Oliveira Mariana , Guilherme Roberta Santos , Meloni Vera Ayres , Di Battista Adriana , de Mello Claudia Berlim , Bragagnolo Silvia , Moretti‐Ferreira Danilo , Kosyakova Nadezda , Liehr Thomas , Carvalheira Gianna Maria , Melaragno Maria Isabel
Published: August 2015

Detailed molecular characterization of chromosomal rearrangements involving X‐chromosome has been a key strategy in identifying X‐linked intellectual disability‐causing genes. We fine‐mapped the breakpoints in four women with balanced X‐autosome translocations and variable phenotypes, in order to investigate the corresponding genetic contribution to intellectual disability. We addressed the impact of the gene interruptions in transcription and discussed the consequences of their functional impairment in neurodevelopment. Three patients presented with cognitive impairment, reinforcing the association between the disrupted genes (TSPAN7—MRX58, KIAA2022—MRX98, and IL1RAPL1—MRX21/34) and intellectual disability. While gene expression analysis showed absence of TSPAN7 and KIAA2022 expression in the patients, the unexpected expression of IL1RAPL1 suggested a fusion transcript ZNF611‐IL1RAPL1 under the control of the ZNF611 promoter, gene disrupted at the autosomal breakpoint. The X‐chromosomal breakpoint definition in the fourth patient, a woman with normal intellectual abilities, revealed disruption of the ZDHHC15 gene (MRX91). The expression assays did not detect ZDHHC15 gene expression in the patient, thus questioning its involvement in intellectual disability. Revealing the disruption of an X‐linked intellectual disability‐related gene in patients with balanced X‐autosome translocation is a useful tool for a better characterization of critical genes in neurodevelopment. © 2015 Wiley Periodicals, Inc.
Electroless Deposition of III–V Semiconductor Nanostructures from Ionic Liquids at Room Temperature
Authors: Lahiri Abhishek , Borisenko Natalia , Olschewski Mark , Gustus René , Zahlbach Janine , Endres Frank
Published: August 2015

Group III–V semiconductor nanostructures are important materials in optoelectronic devices and are being researched in energy‐related fields. A simple approach for the synthesis of these semiconductors with well‐defined nanostructures is desired. Electroless deposition (galvanic displacement) is a fast and versatile technique for deposition of one material on another and depends on the redox potentials of the two materials. Herein we show that GaSb can be directly synthesized at room temperature by galvanic displacement of SbCl3/ionic liquid on electrodeposited Ga, on Ga nanowires, and also on commercial Ga. In situ AFM revealed the galvanic displacement process of Sb on Ga and showed that the displacement process continues even after the formation of GaSb. The bandgap of the deposited GaSb was 0.9±0.1 eV compared to its usual bandgap of 0.7 eV. By changing the cation in the ionic liquid, the redox process could be varied leading to GaSb with different optical properties.
Carbon nanohorn and graphene nanoplate based polystyrene nanocomposites for superior electromagnetic interference shielding applications
Authors: Bera Ranadip , Suin Supratim , Maiti Sandip , Shrivastava Nilesh Kumar , Khatua Bhanu Bhusan
Published: August 2015

In this article is reported the preparation of carbon nanohorn (CNH)/graphene nanoplates (GNP)/polystyrene (PS) nanocomposites through in‐situ bulk polymerization of styrene monomer in the presence of CNH, followed by the addition of suspension polymerized GNP/PS bead during polymerization of styrene, as next‐generation multifunctional material for high electrical conductivity and electromagnetic interference shielding effectiveness (EMI SE) applications. Morphological analysis revealed selective dispersion of CNH in bulk polymerized PS matrix, where GNP/PS beads were randomly distributed. The formation of continuous CNH–CNH conductive path and GNP–CNH–GNP or CNH–GNP–CNH conductive network throughout the PS matrix at exceptionally low loading of CNH (1.0 wt %) and GNP (0.15 wt %) leads to high electrical conductivity (6.24 × 10−2 S cm−1) and EMI SE ∼(−24.83 dB) when the nanocomposites was prepared in the presence of 75 wt % GNP/PS bead. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42803.
Creating a completely “cell‐free” system for protein synthesis
Authors: Smith Mark Thomas , Bennett Anthony M. , Hunt Jeremy M. , Bundy Bradley C.
Published: August 2015

Cell‐free protein synthesis is a promising tool to take biotechnology outside of the cell. A cell‐free approach provides distinct advantages over in vivo systems including open access to the reaction environment and direct control over all chemical components for facile optimization and synthetic biology integration. Promising applications of cell‐free systems include portable diagnostics, biotherapeutics expression, rational protein engineering, and biocatalyst production. The highest yielding and most economical cell‐free systems use an extract composed of the soluble component of lysed Escherichia coli. Although E. coli lysis can be highly efficient (>99.999%), one persistent challenge is that the extract remains contaminated with up to millions of cells per mL. In this work, we examine the potential of multiple decontamination strategies to further reduce or eliminate bacteria in cell‐free systems. Two strategies, sterile filtration and lyophilization, effectively eliminate contaminating cells while maintaining the systems’ protein synthesis capabilities. Lyophilization provides the additional benefit of long‐term stability at storage above freezing. Technologies for personalized, portable medicine and diagnostics can be expanded based on these foundational sterilized and completely “cell‐free” systems. © 2015 American Institute of Chemical Engineers Biotechnol. Prog., 31:1716–1719, 2015
Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH‐SY5Y cells
Authors: E Qun , Tang Miao , Zhang XiaoChuan , Shi YunWei , Wang DanDan , Gu Yun , Li ShiYing , Liang XinMiao , Wang ZhiWei , Wang CaiPing
Published: August 2015

Dibenzocyclooctadiene lignans, the major active components of fruit of Schisandra chinensis (Turcz.) Baill., have been found to have activities that could prevent prostate and thyroid cancer, hepatotoxicity, oxidative stress‐induced cerebral injury, etc. This study was conducted to evaluate the effects of seven dibenzocyclooctadiene lignans of Schisandra chinensis and explore the possible mechanisms in the human neuroblastoma SH‐SY5Y cells exposed on serum and glucose deprivation (SGD) injury. The structure–activity relationships were also analyzed. Cell viability and lactate dehydrogenase (LDH) release were determined to evaluate cell injury. Inflammation and apoptosis‐related protein levels were detected to elucidate the possible mechanisms. Schisantherin A, schizandrin C, and schizandrol B were found to have stronger protective effects than schizandrin A, schizandrin B, and schisanhenol in SH‐SY5Y cells against SGD injury. Moreover, the protective effects of these lignans were possibly exhibited by regulating inflammation and apoptosis‐related proteins in SH‐SY5Y cells after SGD injury, supporting their beneficial effects for the prevention of cell injury in the pathogenesis of the central nervous system diseases, including ischemia stroke. The number and position of hydroxyl group and methylenedioxy in these lignans may be required for their effects.
Double deletion of a chromosome 21 inserted in a chromosome 22 in an azoospermic patient
Authors: Marquet Valentine , Bourgeois Dominique , De Mas Philippe , Bouneau Laurence , Vigouroux‐Castera Adeline , Molignier Romain , Calvas Patrick
Published: August 2015

Key Clinical Message

We report on a phenotypically normal 41‐year‐old azoospermic man with a 45 chromosomes karyotype including one normal chromosome 21, one normal chromosome 22, and a der(22)ins(22;21). ArrayCGHshowed a 1.8 Mb terminal deletion of bands 21pter to 21q21.1 and a 341 kb terminal deletion on band 21q22.3.
Nontraumatic rhabdomyolysis with short‐term alcohol intoxication – a case report
Authors: Papadatos Stamatis S. , Deligiannis Georgios , Bazoukis George , Michelongona Paschalia , Spiliopoulou Aikaterini , Mylonas Stefanos , Zissis Christos
Published: August 2015

Key Clinical Message

Alcohol‐induced rhabdomyolysis is a potentially life‐threatening condition due to the probability of progression to acute renal injury. Patients admitted to emergency department with acute alcohol intoxication should always undergo blood and urine tests for early recognition and treatment of rhabdomyolysis.
Highly‐Dispersed Ni‐QDs/Mesoporous Carbon Nanoplates: A Universal and Commercially Applicable Approach Based on Corn Straw Piths and High Capacitive Performances
Authors: Su Liwei , Hei Jinpei , Wu Xianbin , Wang Lianbang , Wang Yuanhao
Published: August 2015

Metal and metal oxides are extremely competitive in various applications such as catalysis and energy storage, while the intrinsically unsatisfactory ion/electron conductivity and/or large volume swing severely inhibit their inherent potentials. Quantum dots (QDs) can significantly promote the conductivity, buffer volume variation, and introduce novel physical/chemical properties, especially in cooperation with mesoporous carbon (MC), and hence are attracting ever‐increasing attention. However, it is still a worldwide challenge to exploit a facile, efficient, environmentally benign, commercially applicable, and, in particular, universal method for varied QDs/MC hybrids. In this work, a powerful approach is proposed on basis of corn straw piths, and a synthetic mechanism is proposed and investigated systematically. According to this route, Ni, Co, Cu, and MnO QDs/MC nanoplates are successfully fabricated. As a typical example, ultrasmall Ni QDs (5–7 nm) are homogeneously distributed on the large surface of MC nanoplates and exhibit a reversible capacitance of 2420 F g−1 at 500 mA g−1 and rate performance. This work discloses a new and paramount path to exploit versatile QDs/MC hybrids for promising applications such as lithium ion batteries, solar cells, Li–air batteries, and other promising fields with electrochemical catalysts.
Insights into the Gold‐Catalyzed Propargyl Ester Rearrangement/Tandem Cyclization Sequence: Radical versus Gold Catalysis—Myers–Saito‐ versus Schmittel‐Type Cyclization
Authors: Rettenmeier Eva , Hansmann Max M. , Ahrens Alexander , Rübenacker Katharina , Saboo Tapish , Massholder Joy , Meier Christian , Rudolph Matthias , Rominger Frank , Hashmi A. Stephen K.
Published: August 2015

A detailed study of the gold‐catalyzed tandem 1,3‐carboxy migration/allene–enyne cycloisomerization was undertaken. It was found that after the initial allene formation the selectivity of the reaction is strongly influenced by the polarization of the remaining alkyne. Depending on the substitution pattern of the starting diynes, either a Schmittel‐ or a Myers–Saito‐type cyclization was triggered. The 6‐endo‐dig Myers–Saito‐type cyclization gave access to benzo[b]fluorenes, while the Schmittel pathway (5‐exo‐dig) delivered benzofulvenes as final products. In special cases a yet unknown pathway was opened by the ambiphilic nature of the allene moiety. In these cases completely different products were obtained by the nucleophilic attack of the alkyne moiety onto the allene that can also act as an electrophile. Mechanistic studies revealed that diradical pathways can be ruled out for this type of tandem cyclization reactions and it is shown that both steps of the reaction cascade are catalyzed by the gold complex.
Effects of Alkyl Chain Length and Hydrogen Bonds on the Cooperative Self‐Assembly of 2‐Thienyl‐Type Diarylethenes at a Liquid/Highly Oriented Pyrolytic Graphite (HOPG) Interface
Authors: Yokoyama Soichi , Hirose Takashi , Matsuda Kenji
Published: August 2015

Invited for the cover of this issue are Soichi Yokoyama, Takashi Hirose, and Kenji Matsuda at Kyoto University. The image depicts cooperative self‐assembly of diarylethene molecules at solid/liquid interface and its phototriggered transformation. Read the full text of the article at 10.1002/chem.201500707.
ChemInform Abstract: Zn4 Tetrahedra as Basic Building Units in Intermediate‐Valent Ce23Ru7Zn4.
Authors: Niehaus Oliver , Bartsch Timo , Poettgen Rainer
Published: August 2015

Ce23Ru7Zn4 is obtained by melting of the elements in stoichiometric amounts (Nb ampoule, 1500 K, 10 min).
ChemInform Abstract: Visible Light Assisted Photocatalytic Hydrogen Generation by Ta2O5/Bi2O3, TaON/Bi2O3, and Ta3N5/Bi2O3 Composites.
Authors: Adhikari Shiba P. , Hood Zachary D. , More Karren L. , Ivanov Ilia , Zhang Lifeng , Gross Michael , Lachgar Abdou
Published: August 2015

Ta2O5/Bi2O3 core‐shell nanocomposites are prepared by adding Bi(NO3)3 to a suspension of Ta2O5 nanoparticles in BnOH (150 °C, 8 h) followed by calcination at 400 °C (≈80% yield).
ChemInform Abstract: Hydrothermal Synthesis, Nonlinear Optical Property and Photocatalytic Activity of a Non‐centrosymmetric AgIO3 Photocatalyst under UV and Visible Light Irradiation.
Authors: Huang Hongwei , He Ying , Guo Yuxi , He Ran , Lin Zheshuai , Zhang Yihe
Published: August 2015

AgIO3 is prepared by hydrothermal reaction of stoichiometric amounts of AgNO3 and I2O5 in H2O (autoclave, 180 °C, 1 d).
ChemInform Abstract: New Isoformula Borates with Similar Structures and Different Properties — Acentric Nonlinear Optical KGd[B6O10(OH)2] and Centrosymmetric KHo[B6O10(OH)2].
Authors: Belokoneva E. L. , Topnikova A. P. , Stefanovich S. Yu. , Dobretsova E. A. , Volkov A. S. , Dimitrova O. V.
Published: August 2015

Single crystals of KGd[B6O10(OH)2] (I) are prepared by hydrothermal reaction of Gd2(CO3)3, K2CO3, KBr, and B2O3 in the presence of SiO2 (H2O, pH = 5.6, autoclave, 290 °C, 18‐20 d) at pH 5.6 for (I) and pH 7.8 for (II).
ChemInform Abstract: Accidental Formation of Gd4(SiO4)2OTe: Crystal Structure and Spectroscopic Properties.
Authors: Daszkiewicz Marek , Gulay Lubomir D.
Published: August 2015

Single crystals of Gd4(SiO4)2OTe are accidentally obtained while studying the Gd2Te3—Cu2Te system using Gd, Cu, and Te in the molar ratio of 1:1:2 (evacuated quartz tubes, 1420 K, 3 h; cooling to 870 K at a rate of 10 K/h).
ChemInform Abstract: K4Fe3F12: An Fe2+/Fe3+ Charge‐Ordered, Ferrimagnetic Fluoride with a Cation‐Deficient, Layered Perovskite Structure.
Authors: Kim Sun Woo , Zhang Ronghuan , Halasyamani P. Shiv , Hayward Michael A.
Published: August 2015

The title compound is hydrothermally synthesized from an aqueous mixture of FeF2, KF, FeF3, and CF3COOH (autoclave, 230 °C, 24 h, 50% yield).
ChemInform Abstract: Oxidative N‐Heterocyclic Carbene Catalyzed Stereoselective Annulation of Simple Aldehydes and 5‐Alkenyl Thiazolones.
Authors: Lin Li , Yang Yuhong , Wang Mei , Lai Luhao , Guo Yarong , Wang Rui
Published: August 2015

An efficient procedure is elaborated for the NHC‐catalyzed oxidative annulation of thiazolones (I) with aldehydes (II) leading to chiral thiazolopyrones in good yield, and excellent dia‐ and enantioselectivity.
ChemInform Abstract: Control of Oligomerization and Oxidation Steps in the Synthesis of Tris(pentafluorophenyl)corrole.
Authors: Blumenfeld Carl , Fisher Katherine J. , Henling Lawrence M. , Grubbs Robert H. , Gray Harry B. , Virgil Scott C.
Published: August 2015

An improved and scalable synthesis of the title compound (III) is presented.
ChemInform Abstract: Pinene‐Derived Monodentate Phosphoramidites for Asymmetric Hydrogenation.
Authors: Schmitz Christian , Leitner Walter , Francio Giancarlo
Published: August 2015

Newly synthesized phosphoramidite ligands are used in asymmetric catalysis.
ChemInform Abstract: Asymmetric Synthesis of Optically Active 3‐Amino‐1,2‐diols from N‐Acyl‐Protected Allylamines via Catalytic Diboration with Rh[bis(oxazolinyl)phenyl] Catalysts.
Authors: Toribatake Kenji , Miyata Suguru , Naganawa Yuki , Nishiyama Hisao
Published: August 2015

The scalable one‐pot title reaction allows for the transformation of N‐acyl protected amines including imides, amides, and carbamates, bearing a terminal allyl group or, for the first time, a 1,2‐substituted E‐alkene moiety.
ChemInform Abstract: Synthesis of Boron‐ and Silicon‐Containing Amino Acids Through Copper‐Catalyzed Conjugate Additions to Dehydroalanine Derivatives.
Authors: Bartoccini Francesca , Bartolucci Silvia , Lucarini Simone , Piersanti Giovanni
Published: August 2015

A regioselective hydroboration and hydrosilylation of dehydroalanines is presented.
ChemInform Abstract: Phosphahelicenes in Asymmetric Organocatalysis: [3 + 2] Cyclizations of γ‐Substituted Allenes and Electron‐Poor Olefins.
Authors: Gicquel Maxime , Zhang Yang , Aillard Paul , Retailleau Pascal , Voituriez Arnaud , Marinetti Angela
Published: August 2015

The phosphahelicene (PHE) is employed as mixture of two epimers in a 3:2 ratio as catalyst for the synthesis of highly functionalized cyclopentene derivatives.
ChemInform Abstract: Pyridinium Ylide Assisted Highly Stereoselective One‐Pot Synthesis of trans‐2‐(4‐Chlorobenzoyl)‐3‐aryl‐spiro [cyclopropane‐1,2′‐inden]‐1′,3′‐diones and Their Antimicrobial and Nematicidal Activities.
Authors: Banothu Janardhan , Basavoju Srinivas , Bavantula Rajitha
Published: August 2015

13 Title compounds are prepared by a one‐pot two‐step reaction and are screened for their antimicrobial and nematicidal activities.
ChemInform Abstract: Styryl‐Based NLO Chromophores: Synthesis, Spectroscopic Properties, and Theoretical Calculations.
Authors: Yalcin Ergin , Achelle Sylvain , Bayrak Yasmina , Seferoglu Nurguel , Barsella Alberto , Seferoglu Zeynel
Published: August 2015

A series of styryl‐based push‐pull chromophores are synthesized.
ChemInform Abstract: Nitroaldol (Henry) Reaction of 2‐Oxoaldehydes with Nitroalkanes as a Strategic Step for a Useful, One‐Pot Synthesis of 1,2‐Diketones.
Authors: Palmieri Alessandro , Gabrielli Serena , Sampaolesi Susanna , Ballini Roberto
Published: August 2015

A microwave‐enhanced Henry reaction of arylglutaraldehydes with nitro alkanes gives 1,2‐diketones in a one‐pot process through elimination of nitrous acid.
ChemInform Abstract: Copper‐Exchanged Tungstophosphoric Acid: An Efficient and Reusable Heteropoly Acid for the Synthesis of 2,3,4,5‐Tetrahydro‐4‐methylidenefuran Derivatives.
Authors: Aravind Seema , Reddy Narayana
Published: August 2015

Copper‐exchanged tungstophosphoric acid is used as a catalyst for the synthesis of 14 title compounds (III).
ChemInform Abstract: An Easy Access to Benzofurans via DBU Induced Condensation Reaction of Active 2‐Hydroxy Acetophenones with Phenacyl Chlorides: A Novel Class of Antioxidant Agents.
Authors: Rangaswamy J. , Kumar H. Vijay , Harini S. T. , Naik Nagaraja
Published: August 2015

20 Benzofurans are prepared by DBU‐induced condensation of 2‐hydroxy‐acetophenones with phenacyl chlorides.
ChemInform Abstract: Regioselective Metal‐Free One‐Pot Synthesis of Functionalized 2‐Aminothiophene Derivatives.
Authors: Luo Xiaoyan , Ge Li‐Shi , An Xing‐Lan , Jin Jing‐Hai , Wang Yu , Sun Pei‐Pei , Deng Wei‐Ping
Published: August 2015

A facile metal‐free synthetic method to construct 2‐aminothiophene ethers by treating 2‐ynals with thioamides in various alcohols.
ChemInform Abstract: Synthesis of 2‐Heterocyclic Substituted Pyrrolidines by Copper‐Catalyzed Domino Three‐Component Decarboxylative Coupling and Cyclization Reactions.
Authors: Jin Zheng‐neng , Jiang Hua‐jiang , Wu Jia‐shou , Gong Wei‐zhong , Cheng Yue , Xiang Jing , Zhou Qi‐Zhong
Published: August 2015

This novel copper‐catalyzed coupling of 2‐ethynylanilines, cyclic amino acids, and aromatic aldehydes provides a facile approach to a wide variety of indolyl pyrrolidines.
ChemInform Abstract: Synthesis of Bench‐Stable Diarylmethylium Tetrafluoroborates.
Authors: Barbero Margherita , Buscaino Roberto , Cadamuro Silvano , Dughera Stefano , Gualandi Andrea , Marabello Domenica , Cozzi Pier Giorgio
Published: August 2015

This gives exclusively the E isomers of the arylidene‐hetarylium tetrafluoroborates, which can be easily reduced to the corresponding aryl‐hetaryl‐methanes.
ChemInform Abstract: Knoevenagel Condensation of Aromatic Bisulfite Adducts with 2,4‐Thiazolidinedione in the Presence of Lewis Acid Catalysts.
Authors: Mohanty Sandeep , Roy Amrendra Kumar , Sandeep Reddy G. , Vinay Kumar K. P. , RamaDevi B. , Bhargavi G. , Karmakar Arun Chandra
Published: August 2015

The title reaction affords the condensation product directly from the bisulfite adduct.
ChemInform Abstract: Phosphine‐Catalyzed Highly Enantioselective [3 + 3] Cycloaddition of Morita—Baylis—Hillman Carbonates with C,N‐Cyclic Azomethine Imines.
Authors: Zhang Lei , Liu Honglei , Qiao Guanyu , Hou Zhanfeng , Liu Yang , Xiao Yumei , Guo Hongchao
Published: August 2015

The asymmetric [3 + 3] cycloaddition of C,N‐cyclic azomethine imines with aryl‐substituted Morita—Hillman carbonates (II, IV) is developed using a spirocyclic chiral phosphine as the catalyst.
ChemInform Abstract: Greener [3 + 3] Tandem Annulation—Oxidation Approach Towards the Synthesis of Substituted Pyrimidines.
Authors: Vadagaonkar Kamlesh S. , Kalmode Hanuman P. , Prakash Sattey , Chaskar Atul C.
Published: August 2015

In this green protocol for the reaction of α,β‐unsaturated ketones with benzamidine hydrochloride the recyclable choline hydroxide serves as both the catalyst and the reaction medium.
ChemInform Abstract: Synthesis and Spectral Characteristics of Novel Fluorescent Dyes Based on Pyrimido[4,5‐d][1,2,4]triazolo[4,3‐a]pyrimidine.
Authors: Mohadeszadeh Manijeh , Rahimizadeh Mohammad , Eshghi Hossein , Shiri Ali , Gholizadeh Mostafa , Shams Alireza
Published: August 2015

Six title compounds of type (VI) are prepared and their UV/VIS and fluorescence spectra are measured.
ChemInform Abstract: Decarboxylative Alkynyl Termination of Palladium‐Catalyzed Catellani Reaction: A Facile Synthesis of α‐Alkynyl Anilines via ortho C—H Amination and Alkynylation.
Authors: Sun Fenggang , Gu Zhenhua
Published: August 2015

A Pd‐catalyzed Catellani ortho‐amination of iodoarenes is reported.
ChemInform Abstract: Efficient Asymmetric Synthesis of Structurally Diverse P‐Stereogenic Phosphinamides for Catalyst Design.
Authors: Han Zhengxu S. , et al.
Published: August 2015

A general, efficient, and highly enantioselective method for the synthesis of structurally diverse P‐stereogenic phosphinamides is developed.
ChemInform Abstract: Phospho Sulfonic Acid: An Efficient and Recyclable Solid Acid Catalyst for the Solvent‐Free Synthesis of α‐Hydroxyphosphonates and Their Anticancer Properties.
Authors: Kalla Reddi Mohan Naidu , Lee Hye Ri , Cao Jiafu , Yoo Jin‐Wook , Kim Il
Published: August 2015

A small library of biologically active α‐hydroxyphosphonates is prepared by Pudovik reaction of salicylaldehydes with dialkyl phosphites in the presence of a solid acid catalyst.
ChemInform Abstract: Two New Phenylethanoid Glycosides from Callicarpa longissima.
Authors: Yuan Jing‐Quan , Qiu Li , Zou Lu‐Hui , Wei Qian , Miao Jian‐Hua , Yao Xin‐Sheng
Published: August 2015

Two new phenylethanoid glycosides, longissimosides A (I) and B (II), are isolated from the EtOH extract of leaves and stems of Callicarpa longissima together with eight structurally related known compounds.
ChemInform Abstract: Synthesis of Biocompatible Polysaccharide Analogues and Their Application to in vivo Optical Tumor Imaging.
Authors: Miki Koji , Kimura Akinori , Inoue Tatsuhiro , Matsuoka Hideki , Harada Hiroshi , Hiraoka Masahiro , Ohe Kouichi
Published: August 2015

Polysaccharide analogues having 2‐deoxypsicofuranose as a repeating unit are successfully synthesized by ring‐opening metathesis polymerization of 7‐oxanorbornene‐2,3‐diol and dihydroxylation.
ChemInform Abstract: Polyketides and Meroterpenoids from Neosartorya glabra.
Authors: Liu Wen‐Hong , Zhao Hong , Li Rong‐Qun , Zheng Hong‐Bin , Yu Qin
Published: August 2015

Two new polyketides, neosarphenols A (I) and B (II), are isolated from Neosartorya glabra together with six known polyketides.
ChemInform Abstract: Umpolung Pd‐Catalyzed α‐Arylation Reactions in Natural Product Synthesis: Syntheses of (+)‐Xestodecalactone A, (‐)‐Curvularin, (+)‐12‐Oxocurvularin and (‐)‐Citreofuran.
Authors: De Joarder Dripta , Jennings Michael P.
Published: August 2015

Total and formal syntheses of the title phenylacetic acid lactones are accomplished by utilizing a unified strategy of an umpolung Pd‐catalyzed α‐arylation of complex α‐bromo esters and boronic acids under mild reaction conditions.
ChemInform Abstract: Transition Metal Carboxylate Coordination Polymers with Amide‐Bridged Polypyridine Co‐Ligands: Assemblies and Properties
Authors: Zhang Ju‐Wen , Kan Xiao‐Min , Li Xiao‐Li , Luan Jian , Wang Xiu‐Li
Published: August 2015

Review: 90 refs.
ChemInform Abstract: Stabilization of (CuX)n Clusters (X: Cl, Br, I; N: 2, 4, 5, 6, 8) in Mono‐ and Dithioether‐Containing Layered Coordination Polymers
Authors: Harvey Pierre D. , Knorr Michael
Published: August 2015

Review: 64 refs.
ChemInform Abstract: Calixarene‐Based Chemosensors by Means of Click Chemistry
Authors: Song Miaomiao , Sun Zhongyue , Han Cuiping , Tian Demei , Li Haibing , Kim Jong Seung
Published: August 2015

Review: [50 refs.
ChemInform Abstract: Computational Approaches to Understanding the Self‐Assembly of Peptide‐Based Nanostructures
Authors: Tuttle Tell
Published: August 2015

Review: [32 refs.
ChemInform Abstract: Advancements in Aminofluorination of Alkenes and Alkynes: Convenient Access to β‐Fluoroamines
Authors: Chen Pinhong , Liu Guosheng
Published: August 2015

Review: [68 refs.
ChemInform Abstract: Benziporphyrins, a Unique Platform for Exploring the Aromatic Characteristics of Porphyrinoid Systems
Authors: Lash Timothy D.
Published: August 2015

Review: [104 refs.
ChemInform Abstract: Recent Developments in Palladium‐Based Bimetallic Catalysts
Authors: Liao Fenglin , Lo Tsz Woon Benedict , Tsang Shik Chi Edman
Published: August 2015

Review: recent developments in supported Pd bimetallic catalysts used for chemical synthesis, environmental protection, and renewable energy provision; 155 refs.
ChemInform Abstract: Novelty in Complexity: Relationship Between Small Peptides, Pd Nanoparticles, and Catalyst Characteristics
Authors: Molnar Arpad
Published: August 2015

Review: 12 refs.
ChemInform Abstract: Reactivity and Diverse Synthetic Applications of Acyl Isothiocyanates
Authors: Bedane Kibrom G. , Singh Girija S.
Published: August 2015

Review: to the synthesis of biologically important heterocyclic skeletons such as highy functionalized thiazoles, thiadiazoles, triazoles, benzimidazoles, dithiolane, spiro‐fused oxazolines, triazines, and oxazines; 95 refs.
ChemInform Abstract: New Reagents and Synthetic Approaches to the Appel Reaction
Authors: de Andrade Vitor S. C. , de Mattos Marcio C. S.
Published: August 2015

Review: 121 refs.
ChemInform Abstract: Highlights of 50 Years of Ionic Reaction Mechanistic Studies
Authors: Nibbering Nico M. M.
Published: August 2015

Review: 116 refs.
ChemInform Abstract: Recent Advances in Mechanistic Studies of the Aromatic C—H Bond Substitution and Related Chemistry — A Mini‐Review
Authors: Sun Xiaoping
Published: August 2015

Review: 24 refs.
New Sustainable Model of Biorefineries: Biofactories and Challenges of Integrating Bio‐ and Solar Refineries
Authors: Abate Salvatore , Lanzafame Paola , Perathoner Siglinda , Centi Gabriele
Published: August 2015

The new scenario for sustainable (low‐carbon) chemical and energy production drives the development of new biorefinery concepts (indicated as biofactories) with chemical production at the core, but flexible and small‐scale production. An important element is also the integration of solar energy and CO2 use within biobased production. This concept paper, after shortly introducing the motivation and recent trends in this area, particularly at the industrial scale, and some of the possible models (olefin and intermediate/high‐added‐value chemicals production), discusses the opportunities and needs for research to address the challenge of integrating bio‐ and solar refineries. Aspects discussed regard the use of microalgae and CO2 valorization in biorefineries/biofactories by chemo‐ or biocatalysis, including possibilities for their synergetic cooperation and symbiosis, as well as integration within the agroenergy value chain.
Water‐Soluble Iridium‐NHC‐Phosphine Complexes as Catalysts for Chemical Hydrogen Batteries Based on Formate
Authors: Horváth Henrietta , Papp Gábor , Szabolcsi Roland , Kathó Ágnes , Joó Ferenc
Published: August 2015

Molecular hydrogen, obtained by water electrolysis or photocatalytic water splitting, can be used to store energy obtained from intermittent sources such as wind and solar power. The storage and safe transportation of H2, however, is an open and central question in such a hydrogen economy. Easy‐to‐synthesize, water‐soluble iridium‐N‐heterocyclic carbene‐phosphine (IrI‐NHC‐phosphine) catalysts show unprecedented high catalytic activity in dehydrogenation of aqueous sodium formate. Fast reversible generation and storage of hydrogen can be achieved with these catalysts by a simple decrease or increase in the hydrogen pressure, respectively.
Investigating the frequency for load‐independent output voltage in three‐coil inductive power transfer system
Authors: Sun Longzhao , Tang Houjun , Yao Chen
Published: August 2015

Using circuit theory, this letter investigates the output voltage characteristics of three‐coil inductive power transfer (IPT) system against load variations and determines the operating frequency to achieve a constant output voltage. First, a three‐coil IPT system is modeled, and the analytical expression of the root‐mean‐square of the output voltage is derived. By substituting the coupling coefficient, the quality factor, and the resonant frequency, we propose an intuitive method of calculating the frequency for load‐independent output voltage for the first time. When the coupling coefficient is relatively small, there are three frequencies that achieve load‐independent output voltage. If the coupling coefficient increases and is greater than
, only two frequencies can achieve load‐independent output voltage. Experiments are conducted to confirm these conclusions. Copyright © 2015 John Wiley & Sons, Ltd.
Pain‐associated stressor exposure and neuroendocrine values for premature infants in neonatal intensive care
Authors: Rohan Annie J.
Published: August 2015

Recurrent stress during neonatal intensive care taxes the adaptive capacity of the premature infant and may be a risk factor for suboptimal developmental outcomes. This research used a descriptive, cross‐sectional design and a life course perspective to examine the relationship between resting adrenocorticoid values at 37 postmenstrual weeks of age and cumulative pain‐associated stressor exposure in prematurely born infants. Subjects were 59 infants born at under 35 completed weeks of gestation, who were at least 2 weeks of age, and who had been cared for in the NICU since birth. No significant relationships were identified between cortisol values and any of the study variables (number of skin breaking procedures, hours of assisted ventilation, gestational age at birth, exposure to antenatal steroids, history of severe academia, birthweight, days of age to attain birthweight, weight at testing, days of age at testing, recent pain‐associated procedures, and 17‐OHP value). A significant negative correlation (Spearman rank, one‐tailed) between the number of skin‐breaking procedures and 17‐OHP values was identified (r = −.232, p = .039). Recurrent pain‐associated stressor exposure may be a more important factor in explaining the variance of 17‐OHP values at 37 postmenstrual weeks of age than birthweight, gestational age, or chronological age. © 2015 Wiley Periodicals, Inc. Dev Psychobiol 58:60–70, 2016.
Mining from transcriptomes: 315 single‐copy orthologous genes concatenated for the phylogenetic analyses of Orchidaceae
Authors: Deng Hua , Zhang Guo‐Qiang , Lin Min , Wang Yan , Liu Zhong‐Jian
Published: August 2015

Phylogenetic relationships are hotspots for orchid studies with controversial standpoints. Traditionally, the phylogenies of orchids are based on morphology and subjective factors. Although more reliable than classic phylogenic analyses, the current methods are based on a few gene markers andPCRamplification, which are labor intensive and cannot identify the placement of some species with degenerated plastid genomes. Therefore, a more efficient, labor‐saving and reliable method is needed for phylogenic analysis. Here, we present a method of orchid phylogeny construction using transcriptomes. Ten representative species covering five subfamilies of Orchidaceae were selected, and 315 single‐copy orthologous genes extracted from the transcriptomes of these organisms were applied to reconstruct a more robust phylogeny of orchids. This approach provided a rapid and reliable method of phylogeny construction for Orchidaceae, one of the most diversified family of angiosperms. We also showed the rigorous systematic position of holomycotrophic species, which has previously been difficult to determine because of the degenerated plastid genome. We concluded that the method presented in this study is more efficient and reliable than methods based on a few gene markers for phylogenic analyses, especially for the holomycotrophic species or those whoseDNAsequences have been difficult to amplify. Meanwhile, a total of 315 single‐copy orthologous genes of orchids are offered and more informative loci could be used in the future orchid phylogenetic studies.
Clinical trials update from the European Society of Cardiology–Heart Failure meeting 2015: AUGMENT‐HF, TITRATION, STOP‐HF, HARMONIZE, LION HEART, MOOD‐HF, and renin–angiotensin inhibitors in patients with heart and renal failure
Authors: Pellicori Pierpaolo , Clark Andrew L.
Published: August 2015

This article provides an overview on the key trials relevant to the pathophysiology, prevention, and treatment of heart failure (HF) presented at the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) annual meeting held in Seville, Spain in May 2015. Trials reported include AUGMENT‐AF (myocardial injections of calcium‐alginate hydrogel), a propensity score‐matched study of renin–angiotensin system antagonists in patients with HF and severe renal dysfunction, HARMONIZE (sodium zirconium cyclosilicate used to bind potassium), TITRATION, comparing two regimes for introducing LCZ696, STOP‐HF, a trial of intramyocardial stromal cell‐derived factor‐1, MOOD‐HF (escitalopram for patients with heart failure and depression), and LION HEART, a trial of intermittent levosimendan therapy. Unpublished reports should be considered as preliminary, since analyses may change in the final publication.
An Insight into Transfer Hydrogenation Reactions Catalysed by Iridium(III) Bis‐N‐heterocyclic Carbenes
Authors: García Nestor , Jaseer E. A. , Munarriz Julen , Sanz Miguel Pablo J. , Polo Victor , Iglesias Manuel , Oro Luis A.
Published: August 2015

A variety of [M(L)2(L′)2{κC,C′‐bis(NHC)}]BF4 complexes (M = Rh or Ir; L = CH3CN or wingtip group; L′ = I– or CF3COO–; NHC=N‐heterocyclic carbene) have been tested as pre‐catalysts for the transfer hydrogenation of ketones and imines. The conversions and TOF's obtained are closely related to the nature of the ligand system and metal centre, more strongly coordinating wingtip groups yielding more active and recyclable catalysts. Theoretical calculations at the DFT level support a classic stepwise metal‐hydride pathway against the concerted Meerwein–Ponndorf–Verley (MPV) mechanism. The calculated catalytic cycle involves a series of ligand rearrangements due to the high trans effect of the carbene and hydrido ligands, which are more stable when situated in mutual cis positions. The reaction profiles obtained for the complexes featuring an iodide or a trifluoroacetate in one of the apical positions agree well with the relative activity observed for both catalysts.
The impact of different procedures to arouse mortality awareness on various worldview dimensions
Authors: Echebarria Echabe Agustin , Perez Saioa
Published: August 2015

An experimental study was carried out in order to explore two aspects of the terror management theory that have received little attention until now. The first objective was to see whether the different procedures to arouse mortality awareness have the same effects in certain dimensions included within the general construct of ‘worldviews’ (namely, commitment to life‐after‐death beliefs, Eurocentrism and xenophobia, European identity and the importance attached to the family and offspring in personal growth). The second objective was to study the role played by three mediators (emotions, death‐thoughts accessibility and self‐esteem) in the effects of mortality awareness on worldviews. The results revealed that different death reminders influenced different worldview dimensions and that emotions played a major role in the process.
CommIT project plans for single sign‐on for college applicants
Authors: Hope Joan
Published: August 2015

Applying for college is a costly and cumbersome process. That's how participants in the CommIT program define the problem they want to solve.
Enhancing continuous photo‐H2 production using optical fiber for biofilm formation
Authors: Zhang Chuan , Fu Jing , Wang Bao‐Wen , Liu Xin‐Yang , Cheng Min , Zhang Quan‐Guo
Published: August 2015

To promote continuous phototrphic H2 production with photosynthetic bacteria, an innovative annular optical fiber illuminating bioreactor for both biofilm formation and light transmission was developed. Steady biofilm of indigenous photosynthetic bacteria Rhodopseudomonas palustris was successfully obtained on the surface of side‐glowing optical fiber. With the sufficient light supply and uniform light distribution, strategies on improvement of continuous hydrogen production and light energy conversion were then investigated. Hydrogen production rate of 0.85 mmol g−1h−1 and Light conversion efficiency of 47.1% were attained under operating conditions of monochromatic light illumination at 530 nm with light intensity of 19.5 μmol photos m−2s−1, hydraulic retention time of 5 h and initial pH of 7.0. © 2015 American Institute of Chemical Engineers Environ Prog, 35: 455–460, 2016
Temperament and Personality in Bariatric Surgery—Resisting Temptations?
Authors: Claes Laurence , Müller Astrid
Published: August 2015

Temperament and personality traits can serve as both risk factors as well as protective factors in the development of morbid obesity. In the present review, we present an overview of studies focusing on the relationship between temperament/personality and morbid obesity in pre‐operative and postoperative bariatric surgery patients. We consider studies that focus on both a categorical and dimensional point of view on temperament/personality, as well as studies based on cross‐sectional and longitudinal designs. Finally, we will integrate the research findings, discuss the implications for assessment and treatment and formulate suggestions for future research. Copyright © 2015 John Wiley & Sons, Ltd and Eating Disorders Association.
Adsorption and degradation of phenoxyalkanoic acid herbicides in soils: A review
Authors: Paszko Tadeusz , Muszyński Paweł , Materska Małgorzata , Bojanowska Monika , Kostecka Małgorzata , Jackowska Izabella
Published: August 2015

The primary aim of the present review on phenoxyalkanoic acid herbicides—2-(2,4-dichlorophenoxy) acetic acid (2,4-D), 2-(4-chloro-2-methylphenoxy) acetic acid (MCPA), (2R)-2-(2,4-dichlorophenoxy) propanoic acid (dichlorprop-P), (2R)-2-(4-chloro-2-methylphenoxy) propanoic acid (mecoprop-P), 4-(2,4-dichlorophenoxy) butanoic acid (2,4-DB), and 4-(4-chloro-2-methylphenoxy) butanoic acid (MCPB)—was to compare the extent of their adsorption in soils and degradation rates to assess their potential for groundwater contamination. The authors found that adsorption decreased in the sequence of 2,4-DB > 2,4-D > MCPA > dichlorprop-P > mecoprop-P. Herbicides are predominantly adsorbed as anions—on organic matter and through a water-bridging mechanism with adsorbed Fe cations—and their neutral forms are adsorbed mainly on organic matter. Adsorption of anions of 2,4-D, MCPA, dichlorprop-P, and mecoprop-P is inversely correlated with their lipophilicity values, and modeling of adsorption of the compounds based on this relationship is possible. The predominant dissipation mechanism of herbicides in soils is bacterial degradation. The contribution of other mechanisms, such as degradation by fungi, photodegradation, or volatilization from soils, is much smaller. The rate of bacterial degradation decreased in the following order: 2,4-D > MCPA > mecoprop-P > dichlorprop-P. It was found that 2,4-D and MCPA have the lowest potential for leaching into groundwater and that mecoprop-P and dichlorprop-P have slightly higher potential. Because of limited data on adsorption and degradation of 2,4-DB and MCPB, estimation of their leaching potential was not possible. Environ Toxicol Chem 2016;35:271–286. © 2015 SETAC
Development and comparison of four methods for the extraction of antibiotics from a vegetative matrix
Authors: Sallach J. Brett , Snow Daniel , Hodges Laurie , Li Xu , Bartelt-Hunt Shannon
Published: August 2015

Studies have shown the potential for antibiotic uptake into food crops from irrigation water and soils containing pharmaceuticals. The objective of the present study was to develop and compare methods quantifying uptake of antibiotics in food crops. Four methods were evaluated: freeze-and-thaw cell lysing, mechanical maceration, tissue sonication, and microwave-assisted solvent extraction. Four antibiotics (ciprofloxacin, lincomycin, oxytetracycline, and sulfamethoxazole) were tested representing 4 classes of antibiotics. The methods were evaluated based on method detection limits, analyte recoveries, and sample preparation time. The 2 most viable methods, freeze-and-thaw lysing and mechanical maceration, were used on replicate lettuce (Lactuca sativa) samples grown using irrigation water spiked with 3 of the antibiotic contaminants. Only lincomycin and sulfamethoxazole were detected in lettuce samples at concentrations as high as 1757 ng/g and 425 ng/g, with detection limits of 57 ng/g and 35 ng/g, respectively. Freeze-and-thaw cell lysing provided the highest level of extraction efficiency on environmental samples and required the least amount of sample preparation while providing adequate detection limits and reproducible analyte recovery. Environ Toxicol Chem 2016;35:889–897. © 2015 SETAC
Automated Scoring of Speaking Tasks in the Test of English‐for‐Teaching (TEFT™)
Authors: Zechner Klaus , Chen Lei , Davis Larry , Evanini Keelan , Lee Chong Min , Leong Chee Wee , Wang Xinhao , Yoon Su‐Youn
Published: August 2015

This research report presents a summary of research and development efforts devoted to creating scoring models for automatically scoring spoken item responses of a pilot administration of the Test of English‐for‐Teaching (TEFT™) within the ELTeach™ framework. The test consists of items for all four language modalities: reading, listening, writing, and speaking. This report only addresses the speaking items, which elicit responses ranging from highly predictable to semipredictable speech from nonnative English teachers or teacher candidates. We describe the components of the system for automated scoring, comprising an automatic speech recognition (ASR) system, a set of filtering models to flag nonscorable responses, linguistic measures relating to the various construct subdimensions, and multiple linear regression scoring models for each item type. Our system is set up to simulate a hybrid system whereby responses flagged as potentially nonscorable by any component of the filtering model are routed to a human rater, and all other responses are scored automatically by our system.
EPA's Proposed Ozone Rule Challenged by Extensive Texas Study
Authors: Greene Jon
Published: August 2015

Last November, the US Environmental Protection Agency (EPA) proposed a rule that would lower the eight‐hour primary and secondary ozone standards from the current level of 75 parts per billion to a level between 70 and 65 parts per billion. The proposed rule has undergone a few public hearings and is being discussed inside the House of Representatives' Subcommittee on Energy and Power. By court order, the EPA is directed to publish the final rule on or before October 1, 2015.
EPA Draft Report on Hydraulic Fracturing—Very Positive for Natural Gas Supply
Authors: Smead Richard G.
Published: August 2015

In June, the Environmental Protection Agency (EPA) released its draft statement on the potential impact of hydraulic fracturing on drinking water. The report concluded that very little interaction with drinking water had been observed, especially when taking into account the enormous number of wells that have been hydraulically fractured, but also discussed in great detail the exposure that could happen if everything is not done properly.
Connectivity‐based whole brain dual parcellation by group ICA reveals tract structures and decreased connectivity in schizophrenia
Authors: Wu Lei , Calhoun Vince D. , Jung Rex E. , Caprihan Arvind
Published: August 2015

Mapping brain connectivity based on neuroimaging data is a promising new tool for understanding brain structure and function. In this methods paper, we demonstrate that group independent component analysis (GICA) can be used to perform a dual parcellation of the brain based on its connectivity matrix (cmICA). This dual parcellation consists of a set of spatially independent source maps, and a corresponding set of paired dual maps that define the connectivity of each source map to the brain. These dual maps are called the connectivity profiles of the source maps. Traditional analysis of connectivity matrices has been used previously for brain parcellation, but the present method provides additional information on the connectivity of these segmented regions. In this paper, the whole brain structural connectivity matrices were calculated on a 5 mm3 voxel scale from diffusion imaging data based on the probabilistic tractography method. The effect of the choice of the number of components (30 and 100) and their stability were examined. This method generated a set of spatially independent components that are consistent with the canonical brain tracts provided by previous anatomic descriptions, with the high order model yielding finer segmentations. The corpus‐callosum example shows how this method leads to a robust parcellation of a brain structure based on its connectivity properties. We applied cmICA to study structural connectivity differences between a group of schizophrenia subjects and healthy controls. The connectivity profiles at both model orders showed similar regions with reduced connectivity in schizophrenia patients. These regions included forceps major, right inferior fronto‐occipital fasciculus, uncinate fasciculus, thalamic radiation, and corticospinal tract. This paper provides a novel unsupervised data‐driven framework that summarizes the information in a large global connectivity matrix and tests for brain connectivity differences. It has the potential for capturing important brain changes related to disease in connectivity‐based disorders. Hum Brain Mapp 36:4681–4701, 2015. © 2015 Wiley Periodicals, Inc.