bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti-scientific beliefs predict health behaviors during the COVID-19 pandemic
Authors: Johnson Nathanael , Sparks Glenn , Sparks Cheri
Published: July 2023

There exist today many forms of anti-scientific beliefs, from extreme views like the QAnon conspiracies, to misconceptions about vaccines and cancer treatment. The COVID-19 pandemic has presented to us a situation in which the public is being asked by medical experts and politicians alike to trust in science and follow after various health recommendations like wearing masks or getting vaccinated against the virus. We used an anti-science belief scale [Morgan et al., 2018] to assess how preexisting beliefs that run counter to the scientific narrative predict behaviors during the pandemic. We found that people who were more accepting of those anti-scientific positions trusted medical information and experts less and engaged less in recommended health behaviors, while simultaneously showing a more favorable view of Trump's actions as President during the pandemic.
Durability of humoral and cellular immunity six months after the BNT162b2 bivalent booster
Authors: Favresse Julien , Gillot Constant , Closset Mélanie , Cabo Julien , Wauthier Loris , David Clara , Elsen Marc , Dogné Jean-Michel , Douxfils Jonathan
Published: July 2023

Introduction Studies about the duration of the humoral and
cellular response following the bivalent booster administration are
still scarce. We aimed at assessing the humoral and cellular response in
a cohort of healthcare workers that received this booster.
Material and methods Blood samples were collected before the
administration of the bivalent booster from Pfizer-BioNTech and after
14, 28, 90, and 180 days. Neutralizing antibodies against either the
D614G strain, the delta variant, the BA.5 variant, or the XBB.1.5
subvariant were measured. The cellular response was assessed by
measurement of the release of interferon gamma (IFNγ) from T cells in
response to an in vitro SARS-CoV-2 stimulation. Results
A substantial waning of neutralizing antibodies was observed after 6
months (23.1‐fold decrease), especially considering the XBB.1.5
subvariant. The estimated T of neutralizing
antibodies was 16.1 days (95% CI=10.2–38.4 days). Although most
participants still present a robust cellular response after 6 months
(i.e., 95%), a significant decrease was also observed compared to the
peak response (0.41 versus 0.95 UI/L, p=0.0083). Conclusion A
significant waning of the humoral and cellular response was observed
after 6 months. These data can also help national competent authorities
in their recommendation regarding the administration of an additional
booster.
Expressiveness in Stravinsky’s late works
Authors: Flamm Christoph
Published: July 2023

Igor Stravinsky?s late style is usually considered in terms of the works?
structure. Following Joseph N. Straus, this article attempts to highlight
expressive, semantic and self-referential dimensions in Stravinsky?s late
compositions. These dimensions emerge there with particular clarity and
partly contradict the usual assessments of this music as abstract and
constructivist; as such, they also challenge the composer?s own statements.
Fluid pathways within shallow-generated damage zones of strike-slip faults – evidence of map-scale faulting in a continental environment, SW Permo-Mesozoic cover of the Late Palaeozoic Holy Cross Mountains Fold Belt, Poland
Authors: Rybak-Ostrowska Barbara , Konon Andrzej , Hurai Vratislav , Bojanowski Maciej , Konon Agnieszka , Wyglądała Michał
Published: July 2023

The damage zones of exhumed strike-slip faults dissecting Jurassic carbonates in the south-western part of the Late Palaeozoic Holy Cross Mountains Fold Belt reveal second-order faults and fractures infilled with syntectonic calcite. The subsequent development of a structural pattern of microscopic fault-related structures and calcite infillings reflects the activity of strike-slip faults that began in the Late Cretaceous (Late Maastrichtian) and lasted until the early Miocene (Langhian). The fabric of the syntectonic veins provides insights into the evolution of the permeable fault-related structures that were the main pathways for fluid flow during fault activity. Microstructural study of calcite veins coupled with stable isotope and fluid inclusion data indicates that calcite precipitated primarily in a rock-buffered system related to strike-slip fault movement, and secondarily in a partly open system related to the local activity of the releasing Chmielnik stepover or the uplift of the area. The presence of meteoric fluids descending from the surface into damage zones suggest that the strike-slip faulting might have taken place in a nonmarine, continental environment.
Early Pliocene calcareous and siliceous microfossils of the Sawai Bay Formation, Car Nicobar Island, northern Indian Ocean
Authors: Chakraborty Arindam , Ghosh Amit K. , McCartney Kevin , Saxena Stuti , Dey Rikee , Roy Lopamudra
Published: July 2023

The present contribution provides a study of calcareous nannofossils and siliceous microfossils from the Sawai Bay Formation on Car Nicobar Island, northern Indian Ocean. Two stratigraphically short sediment intervals near Sawai Bay have been examined. Qualitative and quantitative microfossil analyses show the Sawai Bay ‘A’ Section to be devoid of siliceous microfossils, while 24 well-preserved calcareous nannofossil taxa are identified. The Sawai Bay ‘B’ Section yields 18 calcareous nannofossil, 33 radiolarian and 25 diatom taxa. The calcareous nannofossil index taxa ( Ceratolithus armatus Müller, 1974a and C. cristatus Kamptner, 1950) indicate both sections to be from zones NN12 (CN10b) and NN13 (CN10c) of early Pliocene (Zanclean) age. The radiolarian taxa, i.e., Didymocyrtis avita Riedel, 1953, Euchitonia spp., Siphocampe lineata (Ehrenberg) Nigrini, 1977, Stichocorys peregrina Riedel, 1953, Semantis spp. and Stylochlamydium sp. are common in the Sawai Bay ‘B’ Section, which is assigned to Zone RN9. Most of the diatom taxa are represented by representatives of the genera Actinocyclus Ehrenberg, 1837, Azpeitia Peragallo in Tèmpere and Peragallo, 1912, Coscinodiscus Ehrenberg, 1839a, Grammatophora Ehrenberg, 1841 and Triceratium Ehrenberg, 1839b, with the benthic diatom species Triceratium favus Ehrenberg, 1839b being predominant (~35% of the total diatom count). Siliceous microfossils are also represented by silicoflagellates dominated by Dictyocha spp. and sponge spicules dominated by astrophorids.
Stratigraphy of the Albian−Cenomanian boundary interval in the Agadir Basin, Morocco: ammonites, microcrinoids, planktonic foraminifera
Authors: Gale Andrew Scott , Kennedy William James , Petrizzo Maria Rose
Published: July 2023

The uppermost Albian and lowermost Cenomanian succession at Abouda Plage, north of Agadir, in the Agadir Basin, western Morocco, is described in detail, and ammonites, microcrinoids and planktonic foraminifera are recorded and illustrated. The lower part of the Aït Lamine Formation yields ammonites indicative of the Pervinquieria (Subschloenbachia) rostrata and P. (S.) perinflata ammonite zones, and the Thalmanninella appenninica planktonic foraminiferan Zone. The base of the Cenomanian is identified at 42.2 m above the base of the Aït Lamine Formation, based on the lowest occurrence of the planktonic foraminiferan Thalmanninella globotruncanoides Sigal, 1948. Lower Cenomanian ammonites of the Graysonites adkinsi Zone enter 3 m higher in the succession. Microcrinoid zones AlR11 and AlR12 are identified in the Upper Albian, and the base of the CeR1 Zone coincides with the lowest occurrence of Cenomanian ammonites. The ammonite and microcrinoid occurrences and detailed distributions are very similar to those found in north central Texas, which, in the Cenomanian, was 5,300 km to the west. The new records suggest that the G. adkinsi Zone is equivalent to the uppermost (Lower Cenomanian) part of the Pleurohoplites briacensis Zone of the Global Stratotype Section for the base of the Cenomanian stage. An hiatus, of global extent, immediately underlies the base of the G. adkinsi Zone and is represented in the Agadir Basin by an erosion surface containing bored and encrusted hiatus concretions.
Campanian–Paleocene Jaworzynka Formation in its type area (Magura Nappe, Outer Carpathians)
Authors: Waśkowska Anna , Golonka Jan , Starzec Krzysztof , Cieszkowski Marek
Published: July 2023

The Campanian–Paleocene Jaworzynka Formation, a part of the Magura Nappe succession in the Polish Outer Carpathians, is described in terms of its detailed litho- and biostratigraphy. The formation stretches along the marginal part of the Siary Unit, from the Jaworzynka stratotype area in the Silesian Beskid Mts up to the Mszana Dolna area in the Beskid Wyspowy Mts. Its equivalent in the Moravskoslezské Beskydy Mts of the Czech Republic is the Soláň Formation. In the stratotype area, the formation displays complex structure. We distinguish four lithological units, i.e., Biotite Sandstone and Shale (I), Shale (II), Mutne Sandstone Member (III) and Thin-bedded Turbidite (IV) and provide the first detailed biostratigraphy of particular units. The first unit forms the most prominent part of the formation. It was deposited in the Middle Campanian–earliest Maastrichtian within the upper part of Caudammina gigantea Zone up to the lower part of the Rzehakina inclusa Zone. The second unit occurs only locally and its age is limited to the Maastrichtian, to the Rzehakina inclusa Zone. The third unit is composed of thick-bedded sandstones that in some parts may form more than the half of the total thickness of the formation. It is Late Maastrichtian–Danian in age and is placed in the upper part of the Rzehakina inclusa Zone and the lower part of the Rzehakina fissistomata Zone. It is usually covered by a thin package of thin-bedded turbiditic sandstone and shales of Danian–Thanetian age with foraminifera of the Rzehakina fissistomata Zone.
The new Northern Copper Belt of south-western Poland: a summary
Authors: Speczik Stanisław , Szamałek Krzysztof , Wierchowiec Jan , Zieliński Krzysztof , Pietrzela Alicja , Bieńko Tomasz
Published: July 2023

The Northern Copper Belt is located in south-western Poland, a region well known for its copper and silver occurrences of varying significance. This area also includes the abandoned mines of the North-Sudetic Trough (Old Copper District), as well as the currently active New Copper District in the southern part of the Fore- Sudetic Monocline. The vast exploration programme of Miedzi Copper Corp. initiated in 2011 in the northern, deeper part of the Fore Sudetic Monocline provided new data about the deeper parts of this geological unit, located north of the known deposits. A number of prospective areas with Cu-Ag mineralization were investigated, which ultimately resulted in the discovery of three new Cu-Ag deposits. Both the prospective areas and the documented deposits form the so-called Northern Copper Belt, which as a whole has high potential for the identification of new ore deposits and an increase in resources. A description of these three new deposits is provided along with characteristics of the areas of their possible extension, and the additional prospective areas with hypothetical and speculative resources. The new deposits are compared to other Polish Cu-Ag ore deposits, with an emphasis on differences in their geological structure and mineralogy. The paper also presents a brief summary of the applied new exploration tools which have led to this discovery.
Enhancing Economic Management with Information Technology: Insights from Covid-19 in Bosnia and Herzegovina Through the Lens of Machine Learning Methods
Authors: Salkić Hadžib , Omerović Aldijana , Salkić Almira , Kvasina Marija
Published: July 2023

This paper explores the role of information technology in enhancing the efficiency of economic management during the COVID-19 pandemic. The research aim was to investigate how the integration of information technology, data usage, and analytics, digital transformation of the financial sector, ensuring digital inclusion and cyber security can contribute to improving economic management in times of crisis. The research methodology involved data collection through a questionnaire that asked participants a series of questions about their attitudes and perceptions regarding the integration of information technology and its impact on the efficiency of economic management during the pandemic. The data were analyzed using the chi-square statistical method to determine the existence of significant relationships between variables. The results indicate that information technology is a key factor in strengthening economic management during the COVID-19 pandemic. The integration of information technology, data usage, and analytics, digital transformation of the financial sector, and ensuring digital inclusion and cyber security can enhance efficiency, transparency, and stability during crisis times. The research emphasizes the need for investment in information technology, the development of implementation strategies, strengthening cyber security, and ensuring digital inclusion as key steps towards building a more resilient economic environment during the pandemic. Further research and implementation of these technologies in practice are recommended to achieve sustainable economic development and successful crisis management.
The Migration Crisis in the European Union and the Postponement of Romania’s Accession to the Schengen Area
Authors: Boicean Danusia , Morar Lucia-Larissa
Published: July 2023

The current major challenge facing the European Union is the phenomenon of migration, with its deep-rooted causes, illegal migration routes, and socio-economic consequences being highly topical issues that require strong interventions, as they bring to the forefront not only inherent costs but also the criminality that accompanies this phenomenon. At the last EU Council meeting for Justice and Home Affairs in December 2022, the admission of Croatia to the Schengen area was approved, while surprisingly, Romania and Bulgaria were rejected. In this context, it is of great interest to analyze the real dimension and concern surrounding the migration phenomenon that led to Austria’s vote against Romania, even though analyzed data presents a different situation, indicating that Bulgaria and Croatia are among the main transit countries, while Romania is only secondary. However, the real problem Austria is facing is a common challenge that must be addressed by the European Union through cooperation between the three categories of countries involved: member states, transit countries, and countries of origin.
The Role of Operational Law in the Development of Military Doctrine
Authors: Guţan Sabin
Published: July 2023

This article is focused on studying the emergence and evolution of operational law as a support for the planning and conducting of military operations in times of peace and war. Issues regarding its curricular area, differences with international humanitarian law, how it can support the evolution of military doctrine and science are addressed. In this context, I analyse the case of the implementation of operational law in the USA, following the military failure in Vietnam, and its role in the reformation of American military doctrine. Finally, I analyse the new reform of the American military law system, the transition from operational law to national security law, triggered by the multiplication of armed threats and the emergence of new types of military actions and battle spaces (especially hybrid warfare, information warfare and cyber warfare). I also analyse the importance of implementing operational law within the Romanian army and the benefits for the evolution of Romanian military doctrine.
Total synthesis of [13C2]-labelled phytosiderophores of the mugineic and avenic acid families
Authors: Kratena Nicolas , Draskovits Markus , Biedermann Nina , Oburger Eva , Stanetty Christian
Published: July 2023

We herein report the synthesis of 13C2-labelled natural products from the mugineic acid and avenic acid family. These phytosiderophores (“plant iron carriers”) are built up from non-proteinogenic amino acids and play a key role in micronutrient uptake in gramineous plants. In this work two central building blocks are prepared from labelled starting materials (13C2-bromoacetic acid, 13C2-glycine) and further employed in our recently reported divergent, branched synthetic strategy delivering eight isotopically labelled phytosiderophores. The required labelled building blocks (13C2-L-allylglycine and a related hydroxylated derivative), were prepared via enantioselective phase-transfer catalysis and enantio- and diastereoselective aldol condensation with a chiral auxiliary respectively, both potentially valuable themselves for other synthetic routes towards labelled (natural) products.
Israel e defesa cibernética: estudo da vinculação Estado, setor privado e academia
Authors: Loose Júlia , Pagliari Graciela De Conti
Published: July 2023

O contínuo avanço das tecnologias de informação e comunicação intensificou o desenvolvimento de um espaço complexo, o ciberespaço, o qual se tornou objeto referente de securitização, proveniente da vinculação entre Estado, corporações privadas e sociedade civil. Em face deste cenário, os Estados passam a compreen- der a esfera cibernética como uma ameaça contemporânea existencial, necessitan- do o desenvolvimento de medidas de infraestrutura de defesa, como no caso de Israel. Busca-se neste artigo analisar quais são as medidas tomadas pelo Estado israelense em termos de infraestrutura de defesa cibernética. A metodologia em- pregada será de técnica de pesquisa de revisão bibliográfica, a partir de fontes primárias, que compreendem uma inicial análise do documento de defesa nacional (publicado ineditamente em 2015) e demais marcos de referência, bem como fontes secundárias. Como conclusões preliminares, infere-se que Israel atribui priorida- de para o setor cibernético em seu plano de defesa multidimensional, tendo uma infraestrutura de defesa formulada a partir da cooperação tripartite entre Estado, setor privado e academia, condicionada devido à sua específica dinâmica regional securitária de legitimidade contestada com presença efetiva de ameaças cibernéti- cas de fontes não tradicionais e tradicionais.
As ruínas da Escola Superior de Guerra em debate
Authors: Salomão Eduardo Rizzatti
Published: July 2023

Em 1975, foram canceladas as obras que acolheriam a transferência da Escola Superior de Guerra (ESG) do Rio de Janeiro para Brasília. Este artigo tem por objetivo inquirir as razões do abandono do projeto e inclui debate de questões do interesse dos estudos de defesa e das relações civis-militares sobre a ESG na atualidade.
Teoria da Complexidade: uma nova opção epistemológica para as Ciências Militares?
Authors: Silva Josias Marcos de Resende , Dias Guilherme Moreira
Published: July 2023

Nas últimas três décadas, a Teoria da Complexidade surgiu como um relevante campo epistemológico dentro da literatura científica ao descrever o comportamento dos sistemas complexos. Simultaneamente, após o término da Guerra Fria, os conflitos armados estão se tornando cada vez mais complexos. Nesse contexto, estudiosos das Ciências Militares têm encontrado inúmeras similaridades entre o fenômeno da guerra e as premissas da Teoria da Complexidade. Dessa forma, o objetivo deste artigo é examinar o uso da Teoria da Complexidade como uma epistemologia adequada para o estudo das Ciências Militares. Após a condução de pesquisa e análise de fontes bibliográficas, foi possível verificar que a guerra comporta-se como um sistema complexo, no qual a não-linearidade e a imprevisibilidade possuem um papel de destaque. Além disso, os resultados encontrados neste estudo vão ao encontro da Teoria da Guerra de Clausewitz, a qual fornece a principal base teórica para a área das Ciências Militares. Portanto, esta pesquisa propõe que a Teoria da Complexidade deve ser reconhecida como uma opção epistemológica válida para o estudo das Ciências Militares.
Hamiləlik zamanı preeklampsiyanın ultrasəs diaqnozu
Authors: J.F. Gurbanova  , N.K. Kaziyeva  , T.T. Kerimova  , S.S. Salmanova  , R.M. Mammadova
Published: July 2023

Hamiləliyin ağırlaşmaları arasında getdikcə "preeklampsiya" termini daha çox səslənir. Bu, hamiləliyin ilk günlərindən gələcək anadan və bir mütəxəssisdən xüsusi diqqət tələb edən ciddi bir patoloji vəziyyətdir. Preeklampsiyanın səbəblərini, diaqnozüsullarını və qarşısının alınması üsullarını bilməklə bir çox problemdən qaça bilmək mümkündür.Preeklampsiya (PE) hamiləliyin nəhəng bir ağırlaşmasıdır, cift çatışmazlığının inkişafına, dölün inkişafının ləngiməsinə səbəb ola bilər ki, bu da öz növbəsində vaxtından əvvəl doğuşun tezliyinin artmasına və operativ doğuşun tezliyinin artmasınagətirib çıxa bilər. [1] PE hamiləliyin ikinci yarısında (20-ci həftədən sonra) baş verən, proteinuriya (gündəlik sidikdə ≥0,3 q/l) ilə birlikdə arterial hipertenziya ilə, tez-tez ödem və çoxlu orqan/polisistemik təzahürlərlə xarakterizə olunan multisistem patolojivəziyyətdir. disfunksiya / çatışmamazlıq. [2]
Hilirisasi produk Smart ENT Unit dinilai sangat bermanfaat bagi mitra Fakultas Kedokteran Universitas Mataram
Authors: Kadriyan Hamsu , Sutawijaya I Gede Pasek , Yudhanto Didit
Published: July 2023

Medical technology continues to grows, both for services and education, thus, innovation is needed. One of these innovations is through the development of the Smart Ear Nose and Throat (ENT) Unit, especially for ear, nose, throat, head and neck surgery (ENT-HNS). In the field of education, this can support problem-based learning (PBL) systems. The development of hardware, software and electronic systems is required in the actualization of this Smart ENT Unit. The method for this community service is by transferring the science and technology that has been produced by the authors to partners. This is to support the use of technology that has been developed by academician to partners, namely the Mataram University Primary Clinic. The result of this community service is in the form of handing over a smart ENT Unit to partners. When the equipment is handed over, assistance is also provided to partners regarding the operation and maintenance of the unit. Eventually, the unit has been used to delivering the health service and education. The conclusion of this community service is that the transfer of the Science and Technology Smart ENT Unit has been successfully completed by the authors. Based on the partner testimonials, the benefits have been felt in regards to this program.
Evaluation of Heavy Metals Concentration in Poultry Feed and Poultry Products
Authors: Hira Iqbal , Munib Ahmed Shafique , Muhammad Jadoon Khan
Published: July 2023

The study was conducted to determine the absorption of essential and non-essential trace minerals from poultry feed to poultry products. Poultry feed, liver, muscles, and egg samples were collected from six poultry farms in Rawalpindi and Islamabad. Mercury, Lead, Cadmium, Chromium, and Iron were analyzed in the samples using Inductively Coupled Plasma Optical Emission Spectrophotometer. Iron, Lead, and Chromium exceeded the permissible limits set by World Health Organization and National Research Council in Poultry feed. Lead was high in the liver, breast muscles, thigh muscles, egg albumen, and egg yolk. Chromium was found in feed, egg yolk, egg albumen, and two (02) of the liver and breast muscle samples. Mercury was not detected in any of the samples. The liver contains significantly higher concentrations of detected heavy metals as compared to thigh and breast muscles and egg yolk contained significantly high concentrations of Iron, Cadmium, and Lead as compared to egg albumen. Standards requirements for feed manufacturers and poultry farmers should be maintained to monitor and mitigate routes of entry of contaminants in the food chain.
Prototipe Sistem Pendekesi Pelangaran Zebra Cross Pada Traffic Light Berbasis Internet Of Things
Authors:   Universitas Hamzanwadi, Gunawan Indra , Sudianto Aris ,   Universitas Hamzanwadi, Hasanah Uswatun ,   Universitas Hamzanwadi
Published: July 2023

In this era, the development of technology in the field of transportation is growing rapidly. This causes the number of vehicles used to facilitate the activities of most people, the need for private vehicles also increase. This condition is increasingly causing overcrowding, especially in rural and urban areas. In order to prevent overcrowding of these vehicles and reduce the rate of accidents on the highway, a traffic light or commonly called a traffic light is needed at every intersection or crossroads. Traffic lights are lights that control and regulate the flow that occurs in traffic. But most motorists lack in obeying traffic rules. In traffic regulations, there is also a zebra cross facility, which serves as a marker for motorists that there is a path for pedestrians to cross the road. However, in reality, even though the number of zebra crossings is quite large and has a size that can be seen, it doesn't seem to work properly. This phenomenon occurs because the increase in the number of motorized vehicles is not accompanied by an increase in public awareness. So we need a tool to make it easier for pedestrians to pass the zebra cross and provide convenience for officers to monitor traffic violations. The tool is a prototype of a motorist violation detection device passing through a zebra cross based on Internet of Things technology using the infrared Proximity Sensor E18-D80NK which is used to detect objects within a distance of 3-80 cm, the buzzer will issue an alarm sound as a warning to comply with traffic regulations in accordance with set. ESP32-Cam to capture images when the driver persists in violating traffic signs and the image will be sent via telegram.
Pengembangan Media Pembelajaran Bangun Ruang Berbasis Augmented Reality
Authors: Arianti Baiq Desi Dwi , Djamaluddin Muhammad , Sabila Hani
Published: July 2023

The implementation of the Merdeka Curriculum (MC) is a program launched by the Indonesian government to enhance the quality of education at all levels. Despite the MC providing flexibility and facilitation for deep learning focused on character development, the utilization of Augmented Reality (AR) in education remains limited in Indonesian schools. Therefore, this research aims to address the research gap and offer research novelty by developing an innovative AR-based spatial geometry instructional media. This study adopts the ADDIE (Analysis, Design, Development, Implementation, Evaluation) methodological approach and involves four experts, including two media experts and two subject matter experts, for the feasibility assessment. Additionally, 25 fifth-grade students from SDN 2 Sandubaya serve as respondents in this research. The findings reveal that the developed instructional media has received high feasibility ratings from media experts (87%) and subject matter experts (84%). Moreover, users' responses towards the application yielded a positive rating of 99%. Thus, this research makes a significant contribution to the field of AR-based instructional media development by addressing the research gap concerning the utilization of AR in spatial geometry education within Indonesian schools. Furthermore, this study offers novelty by introducing an innovative approach to instructional media development, garnering positive user outcomes. The developed instructional media can serve as an effective and engaging resource for spatial geometry education for fifth-grade students
Application Layer Cooperative Automatic Repeat Request Method for Data Streaming over UAVs Network
Authors: Lamri M. A. , Abilov A. , Presnetsov A.
Published: July 2023

In this article, an evaluation study was conducted on an Application Layer Cooperative Automatic Repeat ReQuest Algorithm ALC-ARQ designed for data streaming over a Wi-Fi Unmanned Aerial Vehicles standalone networks. A simulation model in NS-3 was implemented to investigate the performances of the method and conduct a comparative analysis with well-known routing protocols such like Ad hoc On Demand Distance Vector (AODV) and Optimized Link State Routing Protocol (OLSR) in terms of declaring link state information, rapidity of relaying and transmission range. The QoS metrics measured was Packet Loss Rate (PLR) and One-way Transmission Delay. Results show that the proposed method consistently outperform the classical routing protocols it terms of rapidity of relying and transmission range. In addition, the results show that the method maintains its stability it terms of packet recovery along the relay-node transmission range and keeps the QoS metrics under the permissible rates.
A Model for Integrating Edge Computing into an Air-Ground Network Structure and Offloading Traffic Method for High and Ultra-High Densities Internet of Things Networks
Authors: Muthanna A.
Published: July 2023

The scientific challenge of incorporating edge computing into the air-ground network architecture for high and ultra-high density Internet of Things networks is the focus of this article. These issues are particularly important right now because of the concept of "space‒air‒ground‒sea" inegrated networks. A mechanism for offloading traffic from the ground network to mobile edge computing servers on UAVs has also been devised. This network model suggests using mobile edge computing servers deployed on unmanned aerial vehicles (UAVs) to reduce latency and power consumption. At the same time, a software profiler is utilized on the terminal devices to identify the difficulty of the computed task and, based on that determination, a three-level technique for offloading traffic is used.
Knowledge Level of Emergency for Students at Senior High School Al-Azhar Asy Syarif Islamic Boarding School Deli Serdang
Authors: Lubis Andriamuri Primaputra , Khairani Mitra
Published: July 2023

Background: Emergency means life threatening, while emergency is the need to get immediate treatment or action to eliminate the threat to the victim's life. Emergency is a condition when patient's clinical condition requires immediate medical action to save lives and prevent disability. In handling emergency cases, taking the right action for help must be carried out quickly, precisely, and calmly. This study is a cross sectional study. Data was collected in the form of a questionnaire. Questionnaires were collected twice, first the pretest which was carried out before the instructor gave the emergency material and the posttest which was carried out after the emergency material was given. The results show that in general, the posttest results show a shift to a higher score than the pretest results. Conclusion The level of knowledge of students at MA Al-Azhar Asy Syarif Islamic Boarding School Deli Serdang regarding emergencies, is categorized as Good.
The Overbearing CEO: Cinderella Fantasy and Chinese-style Neoliberal Femininity
Authors: SONG Geng
Published: July 2023

In Chinese online romances and TV dramas, the “overbearing CEO” (badao zongcai) is a recurring motif. The stories follow a stereotypical formula, depicting the love between a wealthy and domineering young man, such as a successful businessman, and a girl of humble background. Although there are many variations, the essential constituents present a Cinderella-type fantasy that normalizes patronizing male protagonists and female protagonists who adapt their behaviors to deserve them. Even dramas featuring strong and ambitious women sometimes repeat this motif of romancing an even wealthier male partner. This article situates the “overbearing CEO” stereotype within the wider context of gender subjectivity and class in China today. By close readings of TV dramas, such as Boss and Me ( Shanshan laile), and drawing on data collected from online commentaries and focus group discussions, I examine the ongoing negotiations surrounding gender politics and subjectivity in television’s reproduction of social power relations. I argue that China’s gender hierarchy and ideals are closely associated with “positive energy” (zheng nengliang) moral values, which effectively serve as a new mode of governance in China. As a result, the socialist discourse on gender equality and women’s liberation has to coexist with the interests of a market that pragmatically promotes self-governing subjects. The stories promoting women’s agency as part and parcel of postsocialist modernity thereby paradoxically end up reinforcing the patriarchal gender order.
SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling
Authors: López-Ayllón Blanca D. , de Lucas-Rius Ana , Mendoza-García Laura , García-García Tránsito , Fernández-Rodríguez Raúl , Suárez-Cárdenas José M. , Santos Fátima Milhano , Corrales Fernando , Redondo Natalia , Pedrucci Federica , Zaldívar-López Sara , Jiménez-Marín Ángeles , Garrido Juan J. , Montoya María
Published: July 2023

SARS-CoV-2, the cause of the COVID-19 pandemic, possesses eleven accessory proteins encoded in its genome. Their roles during infection are still not completely understood. In this study, transcriptomics analysis revealed that both WNT5A and IL11 were significantly up-regulated in A549 cells expressing individual accessory proteins ORF6, ORF8, ORF9b or ORF9c from SARS-CoV-2 (Wuhan-Hu-1 isolate). IL11 is a member of the IL6 family of cytokines. IL11 signaling-related genes were also differentially expressed. Bioinformatics analysis disclosed that both WNT5A and IL11 were involved in pulmonary fibrosis idiopathic disease and functional assays confirmed their association with profibrotic cell responses. Subsequently, data comparison with lung cell lines infected with SARS-CoV-2 or lung biopsies from patients with COVID-19, evidenced altered profibrotic gene expression that matched those obtained in this study. Our results show ORF6, ORF8, ORF9b and ORF9c involvement in inflammatory and profibrotic responses. Thus, these accessory proteins could be targeted by new therapies against COVID-19 disease.
Oxidative damage from repeated tissue isolation for subculturing causes degeneration in Volvariella volvacea
Authors: Zhao Fengyun , Wang Qiaoli , An XueMing , Tan Qiangfei , Yun Jianmin , Zhang Yubin
Published: July 2023

The fungal fruiting body is the organized mycelium. Tissue isolation and mycelium succession are common methods of fungal species purification and rejuvenation in the production of edible mushrooms. However, repeated succession increases strain degeneration. In this study, we examined the effect of repeated tissue isolation from Volvariella volvacea fruitbodies on the occurrence of degeneration. The results showed that less than four times in succession improved production capacity, however, after 12 successions, the traits indicating strain degeneration were apparent. For instance, the density of aerophytic hyphae, hyphal growth rate and hyphal biomass were gradually reduced, while the hyphae branching was increased. Also, other degenerative traits such as prolonged production cycles and decreased biological efficiency became evident. In particular, after 19 successions, the strain degeneration became so severe no fruiting bodies were produces anymore. Meanwhile, with the increase in successions, the antioxidant enzyme activity decreased, reactive oxygen species (ROS) increased, the number of nuclei decreased, and the mitochondrial membrane potential decreased along with morphological changes in the mitochondria. This study showed that repeated tissue isolation increased oxidative damage in the succession strain due to the accumulation of ROS, causing cellular senescence, in turn, degeneration in V. volvacea strain.
Detection of endogenous NPY release determined by novel GRAB sensor in cultured cortical neurons
Authors: Christensen Emma Kragelund , Konomi-Pilkati Ainoa , Rombach Joscha , Comaposada-Baro Raquel , Wang Huan , Li Yulong , Sørensen Andreas Toft
Published: July 2023

Neuropeptide Y (NPY) is an abundantly expressed peptide in the nervous system. Its widespread distribution along with its receptors, both centrally and peripherally, indicates its broad functions in numerous biological processes. However, the low endogenous concentration and diffuse distribution of NPY make it challenging to study its actions and dynamics directly and comprehensively. Studies on the role of NPY have primarily been limited to exogenous application, transgene expression, or knock-out in biological systems, which are often combined with pharmacological probes to delineate the involvement of specific NPY receptors. Therefore, to better understand the function of NPY in time and space, direct visualization of the real-time dynamics of endogenous NPY is a valuable and desired tool. Using the first-generation and newly developed intensiometric green fluorescent G-protein-coupled NPY sensor (GRAB NPY1.0), we, for the first time, demonstrate and characterize the direct detection of endogenously released NPY in cultured cortical neurons. A dose-dependent fluorescent signal was observed upon exogenous NPY application in nearly all recorded neurons. Pharmacologically evoked neuronal activity induced a significant increase in fluorescent signal in 32% of neurons, reflecting the release of NPY, despite only 3% of all neurons containing NPY. The remaining pool of neurons expressing the sensor were either non-responsive or displayed a notable decline in the fluorescent signal. Such decline in fluorescent signal was not rescued in cortical cultures transduced with an NPY overexpression vector, where 88% of the neurons were NPY-positive. Overexpression of NPY did, however, result in sensor signals that were more readily distinguishable. This may suggest that biological factors, such as subtle changes in intracellular pH, could interfere with the fluorescent signal, and thereby underestimate the release of endogenous NPY when using this new sensor in its present configuration. However, the development of next-generation NPY GRAB sensor technology is expected soon, and will eventually enable much-wanted studies on endogenous NPY release dynamics in both cultured and intact biological systems.
Physiologically-based pharmacokinetic modeling for single and multiple dosing regimens of ceftriaxone in healthy and chronic kidney disease populations: a tool for model-informed precision dosing
Authors: Alasmari Fawaz , Alasmari Mohammed S. , Muwainea Hussa Mubarak , Alomar Hatun A. , Alasmari Abdullah F. , Alsanea Sary , Alshamsan Aws , Rasool Muhammad F. , Alqahtani Faleh
Published: July 2023

Introduction: Ceftriaxone is one of commonly prescribed beta-lactam antibiotics with several label and off-label clinical indications. A high fraction of administered dose of ceftriaxone is excreted renally in an unchanged form, and it may accumulate significantly in patients with impaired renal functions, which may lead to toxicity.

Methods: In this study, we employed a physiologically-based pharmacokinetic (PBPK) modeling, as a tool for precision dosing, to predict the biological exposure of ceftriaxone in a virtually-constructed healthy and chronic kidney disease patient populations, with subsequent dosing optimizations. We started developing the model by integrating the physicochemical properties of the drug with biological system information in a PBPK software platform. A PBPK model in an adult healthy population was developed and evaluated visually and numerically with respect to experimental pharmacokinetic data. The model performance was evaluated based on the fold error criteria of the predicted and reported values for different pharmacokinetic parameters. Then, the model was applied to predict drug exposure in CKD patient populations with various degrees of severity.

Results: The developed PBPK model was able to precisely describe the pharmacokinetic behavior of ceftriaxone in adult healthy population and in mild, moderate, and severe CKD patient populations. Decreasing the dose by approximately 25% in mild and 50% in moderate to severe renal disease provided a comparable exposure to the healthy population. Based on the simulation of multiple dosing regimens in severe CKD population, it has been found that accumulation of 2 g every 24 h is lower than the accumulation of 1 g every 12 h dosing regimen.

Discussion: In this study, the observed concentration time profiles and pharmacokinetic parameters for ceftriaxone were successfully reproduced by the developed PBPK model and it has been shown that PBPK modeling can be used as a tool for precision dosing to suggest treatment regimens in population with renal impairment.
The effect of group art therapy on acculturative and academic stress of Chinese graduate students in South Korea
Authors: Yin Yue , Ko Kyung Soon
Published: July 2023

Background

Research has shown that international students, specifically Chinese graduate students in South Korea, are vulnerable to stress and depression because of various factors. These include environmental changes, economic constraints, interpersonal difficulties, discrimination, and cultural conflict.

Objective

This study investigates the effectiveness of group art therapy in reducing acculturative stress and academic stress among Chinese graduate students in South Korea.

Method

Thirty participants were recruited and randomly assigned to the experimental (n = 15) and control groups (n = 15). The experimental group received eight 120-min sessions of group art therapy. Both groups were tested for acculturative stress (perceived discrimination, homesickness, perceived hate, fear, stress due to change/culture shock) and academic stress (schoolwork stress, future stress, social stress, living environment stress) before and after the art therapy intervention. Results were compared using the Mann–Whitney U test and the Wilcoxon signed-rank test.

Results

The results showed that there was a significantly greater reduction in acculturative and academic stress in the experimental than the control group.

Conclusion

Group art therapy can provide psychological and emotional support to international students studying abroad.
Crisis due to war: anxiety, depression and stress in the population of 13 Latin American countries
Authors: Mejia Christian R. , Alvarez-Risco Aldo , Chamorro-Espinoza Scherlli , Castillón-Lozano Jorge Andrés , Paucar Medally C. , Padilla-F Valeria J. , Armada José , Vilela-Estrada Martin A. , Serna-Alarcón Victor , Del-Aguila-Arcentales Shyla , Yáñez Jaime A.
Published: July 2023

Sustainability may be at risk in a population that has altered health, according to Sustainable Development Goal 3 (SDG 3): Health and well-being. The ongoing conflict between Russia and Ukraine could jeopardize SDG 3, specifically the mental health of the population. The present study sought to determine the association between severe anxiety, depression and stress in population of 13 Latin American countries according to fear about the war conflict. It was a cross-sectional, analytical and multicenter study. Anxiety, depression and stress were measured with the DASS-21 test (Cronbach’s Alpha: 0.97) and fear due to an armed crisis with a questionnaire already validated in Latin America (Cronbach’s Alpha: 0.92), which was also adjusted for sex, age, education level and country of residence. Descriptive and analytical statistics were obtained. Of the 2,626 respondents, the main fear was that weapons of mass destruction would be used. In the multivariate models, strong associations were found between fear of a possible world-scale armed conflict and having severe or very severe levels of anxiety (aPR: 1.97; 95% CI: 1.64–2.36; value of p <0.001), depression (aPR: 1.91; 95% CI: 1.54–2.36; value of p <0.001) or stress (aPR: 2.05; 95% CI: 1.63–2.57; value of p <0.001). Sustainability linked to SDG 3, specifically mental health, is affected by this type of significant events, given the possible global war crisis that could trigger major events, even more so if added to the deterioration already experienced by COVID-19 in the Latin American region, insecurity and constant political uncertainty.
Learning to play against any mixture of opponents
Authors: Smith Max Olan , Anthony Thomas , Wellman Michael P.
Published: July 2023

Intuitively, experience playing against one mixture of opponents in a given domain should be relevant for a different mixture in the same domain. If the mixture changes, ideally we would not have to train from scratch, but rather could transfer what we have learned to construct a policy to play against the new mixture. We propose a transfer learning method, Q-Mixing, that starts by learning Q-values against each pure-strategy opponent. Then a Q-value for any distribution of opponent strategies is approximated by appropriately averaging the separately learned Q-values. From these components, we construct policies against all opponent mixtures without any further training. We empirically validate Q-Mixing in two environments: a simple grid-world soccer environment, and a social dilemma game. Our experiments find that Q-Mixing can successfully transfer knowledge across any mixture of opponents. Next, we consider the use of observations during play to update the believed distribution of opponents. We introduce an opponent policy classifier—trained reusing Q-learning data—and use the classifier results to refine the mixing of Q-values. Q-Mixing augmented with the opponent policy classifier performs better, with higher variance, than training directly against a mixed-strategy opponent.
Potential Propulsive and Aerodynamic Benefits of a New Aircraft Concept: A Low-Speed Experimental Study
Authors: Bravo-Mosquera Pedro D. , Cerón-Muñoz Hernán D. , Catalano Fernando M.
Published: July 2023

The aerodynamic design of a new aircraft concept was investigated through subsonic wind-tunnel testing using 1:28-scale powered models. The aircraft configuration integrates a box-wing layout with engines located at the rear part of the fuselage. Measurements involved a back-to-back comparison between two aircraft models: a podded version whose engines were assembled on pylons and a boundary-layer ingestion (BLI) version that provided several system-level benefits. The flowfield was investigated through the power balance method and a variety of pressure flowfield and inlet flow distortion metrics. The results proved that the BLI configuration enhances the propulsive efficiency by reducing both the electrical power coefficient and the kinetic energy waste due to lower jet velocities. Furthermore, there was a reduction of the total pressure recovery due to pressure gradients inside the duct, thereby causing high distortion. Overall, this research highlights the importance of wind-tunnel testing to bring any aerodynamic technology to a sufficient level of maturity and to enable future new aircraft concepts.
Reviewing the Adverse Climate Change Impacts and Adaptation Measures on Almond Trees (Prunus dulcis)
Authors: Freitas Teresa R. , Santos João A. , Silva Ana P. , Fraga Helder
Published: July 2023

Climate change is one of the most emergent environmental challenges, with rising global temperatures, changes in precipitation regimes, and an increased frequency and intensity of extreme weather events. Climate change impacts on the agrarian sector are being experienced across the world and are expected to be aggravated in the upcoming decades. Almond fruits are highly sought after due to their economic and nutritional interest, which contribute to their spread throughout the world. In 2021, the world almond production was approximately 3.9 × 106 t with upward of 4.9 × 103 t year−1. Despite being relatively drought- and heat-resistant, this species is also vulnerable to climate change, particularly its production, which is highly dependent on soil water content and air temperature. To address the challenges of climate change, farmers and other stakeholders in the almond industry are increasingly adopting a range of adaptation measures, such as implementing irrigation systems and planting more drought-tolerant almond varieties. This manuscript describes the impacts of climate change on almond cultivation, reviewing the most recent studies on the subject. Furthermore, a comprehensive analysis of possible adaptation strategies against the potentially negative impacts is carried out, which might be of relevance to almond producers and other stakeholders operating in this value chain.