bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Lean Six Sigma in manufacturing setting: a systematic literature review and agenda for future research
Authors: Kumar Sandeep , Swarnakar Vikas , Phanden Rakesh Kumar , Khanduja Dinesh , Chakraborty Ayon
Published: June 2023

Purpose

The purpose of this study is to present the systematic literature review (SLR) on Lean Six Sigma (LSS) by exploring the state of the art on growth of literature on LSS within the manufacturing sector, critical factors to implement LSS, the role of LSS in the manufacturing sector from an implementation and sustainability viewpoint and Industry 4.0 viewpoints while highlighting the research gaps.

Design/methodology/approach

An SLR of 2,876 published articles extracted from Scopus, WoS, Emerald Insight, IEEE Xplore, Taylor & Francis, Springer and Inderscience databases was carried out following the protocol of systematic review. In total, 154 articles published in different journals over the past 10 years were selected for quantitative and qualitative analysis which revealed a number of research gaps.

Findings

The findings of the SLR revealed the growth of literature on LSS within the manufacturing sector. The review also highlighted the most cited critical success factors, critical failure factors, performance indicators and associated tools and techniques applied during LSS implementation. The review also focused on studies related to LSS and sustainability viewpoint and LSS and Industry 4.0 viewpoints.

Practical implications

The findings of this SLR can help senior managers, practitioners and researchers to understand the current developments and future requirements to adopt LSS in manufacturing sectors from sustainability and Industry 4.0 viewpoints.

Originality/value

Academic publications in the context of the role of LSS in various research streams are sparse, and to the best of the authors’ knowledge, this paper is one of the first SLRs which explore current developments and future requirements to implement LSS from sustainability and Industry 4.0 perspective.
The inclusion of immediate and lagged climate responses amplifies the effect of climate autocorrelation on long‐term growth rate of populations
Authors: Evers Sanne M. , Knight Tiffany M. , Compagnoni Aldo
Published: June 2023

Climate variability will increase with climate change, and thus it is important for population ecologists to understand its consequences for population dynamics. Four components are known to mediate the consequences of climate variability: the magnitude of climate variability, the effect size of climate on vital rates, covariance between vital rates and autocorrelation in climate. Recent studies have pointed to a potential fifth component: vital rates responding to climate in different timeframes, with some responding more immediately and some having lagged responses.

We use simulations to quantify how all five components modify the consequences of climatic variability on long‐term population growth rates across a range of life histories defined by life expectancy and iteroparity. We use an established method to compose Matrix Population Models for 147 life histories.

Our simulations show that including different timeframes for vital rates responses to climate can either reduce or amplify the negative influence of climate variability on long‐term population growth rates. The negative effect of different timeframes for vital rates responses on population growth is amplified when climatic autocorrelations are negative, and when species are long‐lived.

Synthesis. The existing literature shows that vital rates often respond to climate in different timeframes, and that studies often ignore climate autocorrelation. Our results show that simultaneously including both of these factors can substantially increase or decrease a population's expected growth rate. Moreover, the relative magnitude of this change increases with the generation time of a life history. Our results are relevant to conservation, population forecasts and population modelling in general.
Getting to the root: Examining within and between home health agency inequities in functional improvement
Authors: Fashaw‐Walters Shekinah A. , Rahman Momotazur , Jarrín Olga F. , Gee Gilbert , Mor Vincent , Nkimbeng Manka , Thomas Kali S.
Published: June 2023

Objective

To quantify racial, ethnic, and income‐based disparities in home health (HH) patients' functional improvement within and between HH agencies (HHAs).

Data Sources

2016–2017 Outcome and Assessment Information Set, Medicare Beneficiary Summary File, and Census data.

Data Collection/Extraction Methods

Not Applicable.

Study Design

We use multinomial‐logit analyses with and without HHA fixed effects. The outcome is a mutually exclusive five‐category outcome: (1) any functional improvement, (2) no functional improvement, (3) death while a patient, (4) transfer to an inpatient setting, and (5) continuing HH as of December 31, 2017. The adjusted outcome rates are calculated by race, ethnicity, and income level using predictive margins.

Principal Findings

Of the 3+ million Medicare beneficiaries with a HH start‐of‐care assessment in 2016, 77% experienced functional improvement at discharge, 8% were discharged without functional improvement, 0.6% died, 2% were transferred to an inpatient setting, and 12% continued using HH. Adjusting for individual‐level characteristics, Black, Hispanic, American Indian/Alaska Native (AIAN), and low‐income HH patients were all more likely to be discharged without functional improvement (1.3 pp [95% CI: 1.1, 1.5], 1.5 pp [95% CI: 0.8, 2.1], 1.2 pp [95% CI: 0.6, 1.8], 0.7 pp [95% CI:0.5, 0.8], respectively) compared to White and higher income patients. After including HHA fixed effects, the differences for Black, Hispanic, and AIAN HH patients were mitigated. However, income‐based disparities persisted within HHAs. Black‐White, Hispanic‐White, and AIAN‐White disparities were largely driven by between‐HHA differences, whereas income‐based disparities were mostly due to within‐HHA differences, and Asian American/Pacific Islander patients did not experience any observable disparities.

Conclusions

Both within‐ and between‐HHA differences contribute to the overall disparities in functional improvement. Mitigating functional improvement inequities will require a diverse set of culturally appropriate and socially conscious interventions. Improving the quality of HHAs that serve more marginalized patients and incentivizing improved equity within HHAs are approaches that are imperative for ameliorating outcomes.
Addressing the atomic bomb damage: Associations between ‘state compensation’ demands and aspects of survivors' suffering
Authors: Vasileva Vladisaya Bilyanova , Izumi Shizue , Kawano Noriyuki
Published: June 2023

To address the long‐lasting consequences of the atomic bombings in Hiroshima and Nagasaki, in 1994, the Japanese government implemented the current in‐force Atomic Bomb Survivors Support Law. This substantial policy offers medical, health and welfare measures and even incorporates some reparations‐like aspects. Nevertheless, atomic bomb survivors' organisations have severely criticised the government for failing to adequately address the entirety and inhumanity of the atomic bomb damage by refusing to enact the law on a clearly stated principle of ‘state compensation’. As such, we attempt to clarify empirically what aspects of survivors' suffering are most closely associated with their demands for ‘state compensation’. Based on statistical model‐based analysis, survivors who deem that ‘state compensation’ should be enacted experience frequent flashbacks of the bombings, disadvantaged life opportunities and economic concerns, among others. We conclude the study by considering the difficulty in addressing the consequences of nuclear weapons use and testing through programmes that approximate, but fail to establish, clear reparations‐based measures, such as the current Atomic Bomb Survivors Support Law.
Reproductive and morphological analysis of the trairão Hoplias intermedius in the São Francisco River, downstream from a large reservoir
Authors: Diniz Mateus Augusto Silva , Marcon Lucas , Ervilha Bernardo Borges , dos Santos José Enemir , Rizzo Elizete , Bazzoli Nilo
Published: June 2023

Hoplias intermedius, of the Characiformes order and Erytrinidae family, is widely distributed across South America. This commercially interesting species can reach a length of 100 cm and a weight of 15–20 kg. To evaluate the reproductive biology of H. intermedius in the São Francisco River, Brazil, 154 males and 190 females were captured bi‐monthly between September 2018 and August 2019 from the downstream regions of the Três Marias dam. Gillnets with differently sized meshes were deployed at distances of 34–54 km after the confluence with the Abaeté River (18°00′49″ S, 45°10′51″ W). Biometric data, gonadosomatic index (GSI), Fulton condition factor (K) and absolute fecundity (AF) were determined for each specimen. Gonad maturation stages and the spawning season were also established. The biometric data, GSI and K average values were relatively higher in females than in males. The reproductive peak for both sexes was reached around January/February. The mean AF was 4300.5 ± 1451.2 follicles per female. Fully developed vitellogenic follicles had a mean diameter of 1014.8 ± 250.7 μm, which is characteristic of fish with moderate fecundity. Fish of all maturation stages, from mature, spawned and spermed, occurred in all bimesters, indicating that this species reproduced throughout the year. The high frequency of spawning females throughout the year and the histological characteristics of spawned ovaries indicated that trairão H. intermedius' spawning type is partial.
Computed tomographic and magnetic resonance imaging anatomy of the coelomic cavity in market‐age commercial Pekin Ducks (Anas platyrhynchos domesticus)
Authors: Abraham Meagan E. , Wakamatsu Nobuko , Lossie Geoffrey A. , Karcher Darrin M. , Heng Hock Gan , Murakami Masahiro
Published: June 2023

Approximately 27 million ducks are raised commercially in the US each year and Pekin ducks (Anas platyrhynchos domesticus) are the most commonly raised breed. Additionally, an increasing number of Americans are raising small flocks of poultry, which often include ducks, in their own backyards. This creates a need to better understand the imaging anatomy of ducks. However, in avian species, superimposition of organs limits evaluation of the coelomic cavity using the most common imaging modality, radiography. The use of cross‐sectional imaging including computed tomography (CT) and magnetic resonance imaging (MRI) has increased in veterinary medicine research and clinical use. An anatomic atlas is essential for guiding research and diagnostic imaging. To date, no CT or MRI atlas exists for Pekin ducks. The purpose of the study is to generate a CT atlas of market‐age Pekin ducks as well as CT attenuation values and measurements of coelomic organs with corresponding gross and MRI images. A total of 20 market‐age, commercial Pekin ducks were imaged. Five male and five female ducks were imaged with CT; four of these ten ducks, two male and two female, were frozen and sliced in approximately 5 mm transverse sections for gross anatomic reference images. Six additional ducks, three male and three female ducks, were dissected to measure major organs. Four additional ducks were imaged using CT and MRI and necropsied for gross anatomical comparisons and landmarks. The atlas contained here may be used for future research projects and clinically to aid in diagnosis of disease in ducks.
Stakeholder perceptions of human–predator conflict in the South African fly‐fishing industry
Authors: de Vos Marié , McIntyre Trevor
Published: June 2023

Human–wildlife conflict in African aquaculture and fisheries is poorly understood. We investigated this conflict through a questionnaire aimed at owners and managers of fly‐fishing properties in South Africa. While perceptions of losses varied, all respondents reported losses to predators. Resulting mitigation measures, including lethal control, were employed mostly against cormorants (Phalacrocorax spp.) and otters (Aonyx capensis and Hydrictis maculicollis). Given that fly‐fishing properties potentially provide valuable habitat for protected species such as otters, our results highlight a need for improved mitigation measures and exploring alternative options of potentially generating income from tourism associated with the presence of charismatic predators.
Market States and Lottery Preference: Evidence from Chinese Open‐End Funds*
Authors: He Rongxin , Hsieh Pei‐Lin
Published: June 2023

Recent studies find that investors prefer funds with lottery‐like payoffs. Using a sample of Chinese open‐end funds, we show that investors' preference for funds' extreme positive payoffs (MAXs) depend on the state of the market: it is significant for MAXs in an unfavorable market but weak or reversed for those in a favorable market. Such state‐dependent preference is irrational because, inconsistent with the flow–MAX relationship, higher MAXs under market downturns are associated with worse performance. We further document support for the salience‐theory‐based explanation for investors' preference and provide counter‐evidence for alternative mechanisms based on rational choice or changes in aggregate flows.
Kitchen phenomenologies: Antiromantic poetics of space and food in the Anthropocene
Authors: Astorga de Ita Diego
Published: June 2023

This paper considers the kitchen and the phenomenological values that emerge from it. In this text the kitchen is seen as a space of possibility within the context of the Capitalocene, from which new values and imaginations for a more sustainable future may emerge. Drawing upon ecofeminist critiques and feminist food studies, and building upon the phenomenologies of space of Gaston Bachelard and Yi‐Fu Tuan, this exploration surveys how intimacy, memory, care, and relation emerge from kitchen endeavours and what these notions mean for a Capitalocenic world. These theoretics are intertwined with ethnographic materials on foodscapes and foodways gathered in Xochimilco, Mexico City. From this, radical conceptualisations of the kitchen emerge and everyday phenomenologies spread into new spaces, while bringing together these subjects with environmental issues. I propose the notion of the antiromantic as an approach emerging from the kitchen's history as a gendered and contested space, and as a way to approach the kitchen and its labours in the midst of our current ecological crises; in this way the kitchen can be understood and inhabited as a political space of possibility for sustainable transformations.
Long‐term course of cognitive functioning in bipolar disorder: A ten‐year follow‐up study
Authors: Flaaten Camilla Bärthel , Melle Ingrid , Bjella Thomas , Engen Magnus Johan , Åsbø Gina , Wold Kristin Fjelnseth , Widing Line , Gardsjord Erlend , Øie Merete Glenne , Lyngstad Siv Hege , Haatveit Beathe , Simonsen Carmen , Ueland Torill
Published: June 2023

Introduction

Cognitive impairments are common in bipolar disorder (BD), but the long‐term course remains understudied. Longitudinal data on cognitive functioning from the start of the first treatment could help clarify pathophysiological processes that shape the illness outcome. We here aim to investigate the 10‐year cognitive course in BD compared to healthy controls (HC) and the effects of clinical symptoms on cognitive trajectories.

Methods

Fifty‐six BD participants recruited within their first year of treatment and 108 HC completed clinical and cognitive assessments at baseline and 10‐year follow‐up. We derived eight cognitive domain scores and a cognitive composite score, which were further investigated using linear mixed model analyses. Correlation analyses were used to assess associations between the composite score and depressive, manic and psychotic symptoms.

Results

BD participants performed poorer than HCs in all domains except mental speed and verbal fluency. Verbal learning and memory, verbal fluency and the composite score improved over time in both BD participants and HC, while short‐term memory, mental speed, psychomotor speed and working memory were stable. We found no significant correlations between cognition and symptom level at either time point in BD participants.

Conclusions

We found evidence of long‐term cognitive stability or improvement in BD participants from first treatment to 10‐year follow‐up. Though the BD group was impaired in all domains except mental speed and verbal fluency, the change in cognitive functioning was parallel to that of HCs. These findings are not consistent with the notion of neuroprogression in BD.
Patient‐derived xenograft models of ALK+ ALCL reveal preclinical promise for therapy with brigatinib
Authors: Prokoph Nina , Matthews Jamie D. , Trigg Ricky M. , Montes‐Mojarro Ivonne A. , Burke G. A. Amos , Fend Falko , Merkel Olaf , Kenner Lukas , Geoerger Birgit , Johnston Robert , Murray Matthew J. , Riguad Charlotte , Brugières Laurence , Turner Suzanne D.
Published: June 2023

Anaplastic large‐cell lymphoma (ALCL) is a T‐cell malignancy predominantly driven by the oncogenic anaplastic lymphoma kinase (ALK), accounting for approximately 15% of all paediatric non‐Hodgkin lymphoma. Patients with central nervous system (CNS) relapse are particularly difficult to treat with a 3‐year overall survival of 49% and a median survival of 23.5 months. The second‐generation ALK inhibitor brigatinib shows superior penetration of the blood–brain barrier unlike the first‐generation drug crizotinib and has shown promising results in ALK+ non‐small‐cell lung cancer. However, the benefits of brigatinib in treating aggressive paediatric ALK+ ALCL are largely unknown. We established a patient‐derived xenograft (PDX) resource from ALK+ ALCL patients at or before CNS relapse serving as models to facilitate the development of future therapies. We show in vivo that brigatinib is effective in inducing the remission of PDX models of crizotinib‐resistant (ALK C1156Y, TP53 loss) ALCL and furthermore that it is superior to crizotinib as a second‐line approach to the treatment of a standard chemotherapy relapsed/refractory ALCL PDX pointing to brigatinib as a future therapeutic option.
Extent and variability of Mesozoic‐Cenozoic multi‐stage salt diapirs in the Southern Permian Basin, Southern North Sea
Authors: Gaitan G. , Adam J.
Published: June 2023

Salt structures can be used as an archive for tectonic and depositional processes as all salt structures respond distinctively. Few salt tectonic studies have investigated the evolution of multi‐stage salt structures, nevertheless, no previous study had systematically identified, mapped, nor classified, the evolution of multi‐stage salt structures in a regional study. Decades of hydrocarbon exploration and the heavily dense 3D seismic data available, make the Southern North Sea one of the best natural laboratories to investigate the evolution of salt structures. The Southern North Sea salt basin is a Late Permian Zechstein salt mega‐basin containing a myriad of salt structures. The complex tectonic evolution of the Southern North Sea created diverse Mesozoic structural sub‐basins with different tectonostratigraphic evolutions. We defined a nomenclature, linked to the mega‐stratigraphic sequences, for the classification of salt structures. We used a Two‐Way‐Travel‐Time 3D seismic reflection dataset and time‐thickness variations around salt structures to systematically analyse the evolution of salt structures across the diverse structural sub‐basins of the Southern North Sea. Multi‐stage salt diapirs were triggered halokinetically in the Early Triassic and are linked to regional palaeo‐depocentres controlled by the sub‐Zechstein structural configuration. Multi‐stage salt diapirs in the different sub‐basins evolved through three different regional phases and up to five distinctive local stages. The most complex salt diapirs developed in the Central Graben, Sole Pit High and Silver Pit Basin, where multi‐stage salt diapirs showed 4–5 local stages of salt diapirism. The multi‐stage evolution of salt structures should be thoroughly investigated to reduce risks and uncertainties in the energy sector and net zero projects, such as in carbon capturing and storage projects, and energy storage in man‐made salt caverns.
Interspecific behavioural interference and range dynamics: current insights and future directions
Authors: Patterson Christophe W. , Drury Jonathan P.
Published: June 2023

Novel biotic interactions in shifting communities play a key role in determining the ability of species' ranges to track suitable habitat. To date, the impact of biotic interactions on range dynamics have predominantly been studied in the context of interactions between different trophic levels or, to a lesser extent, exploitative competition between species of the same trophic level. Yet, both theory and a growing number of empirical studies show that interspecific behavioural interference, such as interspecific territorial and mating interactions, can slow down range expansions, preclude coexistence, or drive local extinction, even in the absence of resource competition. We conducted a systematic review of the current empirical research into the consequences of interspecific behavioural interference on range dynamics. Our findings demonstrate there is abundant evidence that behavioural interference by one species can impact the spatial distribution of another. Furthermore, we identify several gaps where more empirical work is needed to test predictions from theory robustly. Finally, we outline several avenues for future research, providing suggestions for how interspecific behavioural interference could be incorporated into existing scientific frameworks for understanding how biotic interactions influence range expansions, such as species distribution models, to build a stronger understanding of the potential consequences of behavioural interference on the outcome of future range dynamics.
Birds of a feather flock together: How and when does the fit of CEO–CFO high promotion focus predict new venture initial public offering fraud?
Authors: Gong Mijia , Zhang Zhe , Yang Xiaohua , Jia Ming
Published: June 2023

Research Question/Issue

This study attempts to examine how the fit of CEO and CFO high promotion focus, an important motivational‐based psychological trait, can affect new venture initial public offering (IPO) fraud. Furthermore, we explore how this relationship is moderated by CEO–CFO status similarity (firm internal environment) and environmental dynamism (firm external environment).

Research Findings/Insights

Using a sample of Chinese new ventures listed on growth enterprise market from 2010 to 2016, we conduct computer‐aided content analysis to quantify CEO and CFO promotion focus. Results show that the fit of CEO–CFO high promotion focus increases the likelihood of new venture IPO fraud. Moreover, CEO–CFO status similarity and environmental dynamism strengthen this positive relationship.

Theoretical/Academic Implications

We make three main contributions to the literature. First, we enrich upper echelons literature on CEO–top management team (TMT) interface by exploring how the psychological characteristic (promotion focus) of CEO–CFO dyad, a subteam of TMT, affects new venture IPO fraud. Second, we contribute to regulatory focus theory by extending interpersonal promotion fit to the context of upper echelons level and exploring its boundary conditions of CEO–CFO status similarity (internal environment) and environmental dynamism (external environment). Third, from the perspective of microfoundation, this study contributes to IPO fraud literature by investigating the antecedents of firm internal factors, specifically the psychological trait—high promotion focus fit of CEO–CFO.

Practitioner/Policy Implications

By examining the fit of CEO and CFO high promotion focus, this study shows the need to consider the motivational‐based psychological traits of CEO and CFO when selecting, training, monitoring, dismissing, and compensating executives. Moreover, to prevent new venture IPO fraud, policymakers and key stakeholders such as the board of directors can consider paying much attention to firms with CEO and CFO who possess high promotion focus.
Redefining crisis in museums: Insiders perspectives on digital engagement
Authors: Wilson‐Barnao Caroline , Middleton Craig , Enright Lisa
Published: June 2023

COVID‐19 has highlighted the need for museums to develop policies and practices that allow them to be more responsive to audiences' during a crisis, in many cases pushing them to explore new technologies and approaches. Based on an analysis of the National Museum of Australia and its digital engagement throughout the 2019/2020 bushfire season and the COVID‐19 pandemic, this paper identifies a lack of literature to support the need for digital channels to be incorporated in institutional crisis planning. Referencing “Momentous”, a purpose‐built website, and two Facebook groups, “Fridge Door Fire Stories” and “Bridging the Distance,” we explore the content shared on these platforms by users and place this in conversation with the reflections of the cultural workers who created and maintained these online platforms. We suggest digital technologies help communities to take a more active role in negotiating how the museum represents their experiences.
Bioprosthetic aortic valve thrombosis under effective direct oral anticoagulant therapy
Authors: Guler Arda , Erata Yunus Emre , Aydin Sinem , Gunes Haci Murat , Babur Guler Gamze
Published: June 2023

With the increase in transcatheter procedures, the use of bioprosthetic valves has become more frequent in clinical practice. However, the optimal antithrombotic management of patients with bioprosthetic valves remains controversial. In this case report, we describe a patient with a bioprosthetic aortic valve who developed a thrombus while receiving effective dose direct oral anticoagulant (DOAC) therapy. A 73‐year‐old male patient with a bioprosthetic aortic valve replacement 2 years prior presented with a mobile thrombus and early degeneration of the valve, detected during routine follow‐up while being treated with apixaban. Although the valve thrombus regressed after switching to a different anticoagulant drug, we observed that the decreased but still high gradient persisted due to the early degeneration. Anticoagulant management of bioprosthetic valve patients demands careful attention. Although evidence supporting the use of DOACs is growing, close patient follow‐up and further evaluation in case of doubt remain critical. The development of a thrombus in a bioprosthetic valve patient who is receiving anticoagulation therapy, as in this case, highlights the need for optimal management to prevent thromboembolic complications and valve degeneration.
The harm of humiliation
Authors: Laing James
Published: June 2023

My aim in this paper is to show that the natural idea that humiliation is harmful calls explanation and to argue that the most straightforward ways of responding to this explanatory demand fall short in important ways. I end by considering a line of response which I take to be promising, which appeals to our need, as social animals, for interpersonal connection.
Topical metformin 30% gel in the treatment of acne vulgaris in women, a split face, placebo‐controlled study
Authors: EL‐Komy Mohamed H. M. , Abdo Nesma Moustafa Kamel , Shamma Rehab Nabil , Bedair Nermeen Ibrahim
Published: June 2023

Acne vulgaris (AV), a widely common disorder, that negatively affects the quality of life. Metformin is a relatively safe, cheap and well tolerated drug that is widely used in the treatment of Diabetes. Systemic metformin has demonstrated promising results in treating acne, while topically it was studied for melasma and recalcitrant central centrifugal cicatricial alopecia. To study the safety and efficacy of topical metformin 30% in the treatment of AV. Twenty‐seven female AV patients were asked to blindly apply metformin and placebo gels to either side of the face for 12 weeks. AV lesion count was performed at baseline, at each visit and 4 weeks after end of treatment. At the end of the treatment period, the treated side showed significant improvement of comedones, papules and nodules but not pustules. Although, lesions count increased 1 month after stopping treatment, comedones and papules numbers were still significantly less on the metformin side compared to placebo. No side effects were reported. The limited number of patients studied and the limited follow‐up period. The metformin effect was not studied on cellular and molecular levels. Topical metformin nanoemulsion gel can be a promising safe and effective treatment of AV.
Fathers' status and role identities and involvement shortly after divorce
Authors: Petren Raymond E. , Ferraro Anthony J.
Published: June 2023

Objective

The goal was to examine (a) whether fathers' role‐level and status‐level identity salience are associated with father involvement (engagement, affection, responsibility) following divorce and (b) whether barriers to father involvement (coparenting relationship, divorce decree dissatisfaction) moderate associations between identity and involvement.

Background

Father identity has been established as a predictor of father involvement. However, little is known about the effects of role‐level identity domains (caregiver identity, provider identity). Also, contextual factors may interfere with or support the enactment of father identities.

Method

Fathers from a southeastern state (n = 116) who had experienced divorce within the past 3 months were included. Hierarchical regression was used to examine direct associations and moderation effects among key indicators.

Results

Fathers' identity status salience was positively associated with engagement. Caregiving role salience was positively associated with responsibility. Provider role salience was positively associated with affection when coparenting cooperation was high and negatively associated with both affection and responsibility when coparenting cooperation was low.

Conclusion

Findings suggest the importance of both the general father identity and role‐level identities to father involvement shortly following divorce. Coparenting cooperation may be an important mechanism for fostering involvement, especially for fathers who more strongly identify as financial providers.
Casting and spinning aluminum alloy wheel fatigue properties and life prediction study
Authors: Zhang Mengxiao , Song Hongwu , Yan Weihao , Yue Fengli , Yang Baocheng , Chen Shuaifeng , Zhang Shihong
Published: June 2023

To accurately predict the fatigue life of cast aluminum alloy wheels, based on the results of finite element calculation and simulation, this work selected the rim area, inner flange and spoke areas to conduct systematic tensile and high‐cycle fatigue tests. The results show that the tensile properties of A356‐T6 cast aluminum alloy wheels are similar in various areas, but the fatigue properties are significantly different. Plastic deformation can improve the fatigue strength of the aluminum alloy, but the fatigue properties are also affected by deformation uniformity and other factors. Based on the difference of mechanical properties in different areas, this study also selected the characteristic loading spectrum to predict the fatigue life of wheels. A linear and a nonlinear damage accumulation were employed. The above methods are not only applicable to the wheel, but also provides a new idea for the life prediction of key parts in the engineering field.
ComparativeLCAstudies of simulatedHMFbiorefineries from maize and miscanthus as an example of first‐ and second‐generation biomass as a tool for process development
Authors: Götz Markus , Lask Jan , Lewandowski Iris , Kruse Andrea
Published: June 2023

5‐Hydroxymethylfurfural (HMF) is a versatile platform chemical for a fossil free, bio‐based chemical industry. HMF can be produced by using fructose as a feedstock. Using edible, first‐generation biomass to produce chemicals has been questioned in terms of potential competition with food supply. Second‐generation biomass like miscanthus could be an alternative. However, there is a lack of information if second‐generation lignocellulosic biomass is a more sustainable feedstock to produce HMF. Therefore, a life cycle assessment was performed in this study to determine the environmental impacts of HMF production from miscanthus and to compare it with HMF from high‐fructose corn syrup (HFCS). HFCS from either Hungary or Baden‐Württemberg (Germany) was considered. Compared to the HFCS biorefineries the miscanthus concept is producing less emissions in all impact categories studied, except land occupation. Overall, the production and usage of second‐generation biomass could be especially beneficial in areas where the use of N fertilizers is restricted. Besides, conclusions for the further development of the on‐farm biorefinery concept were elaborated. For this purpose, process simulations from a previous study were used. Results of the previous study in terms of TEA and the current LCA study in terms of environmental sustainability indicate that the lignin depolymerization unit in the miscanthus biorefinery has to be improved. The scenario without lignin depolymerization performs better in all impact categories. The authors recommend to not further convert the lignin to products like phenol and other aromatic compounds. The results of the contribution analyses show that the major impact in the HMF production is caused by the auxiliary materials in the separation units and the required heat. Further technical development should focus on efficient heat as well as solvent use and solvent recovery. At this point further optimizations will lead to reduced emissions and costs at the same time.
Exploring the identity development of PhD graduates transitioning to non‐researcher roles
Authors: Li Huan , Horta Hugo
Published: June 2023

In this study, we explore the identity development of PhD graduates transitioning into non‐researcher roles. Through the conceptual lens of identity‐trajectory theory and based on interviews with 26 PhD graduates from three leading research universities in Hong Kong, Macau and Taiwan, we analyse their identity‐trajectory development after their transition to non‐research employment. The findings show that PhD graduates develop their identity trajectories based on their existing sense of researcher‐self through a variety of practices that involve intellectual, networking and institutional dimensions. Individual agency plays a key role in overcoming structural constraints in the workplace, yet its level varies according to one's willingness to pursue a non‐research career. The findings highlight the fluidity in identity development and the role of the researcher‐self as a positive legacy of doctoral training, including for PhD graduates taking non‐researcher roles.
DEFENDING SPIRIT, SPIRITUALIZING MATTER: NINETEENTH‐CENTURY FRENCH ACADEMIC PHILOSOPHY AND THE MEDICAL SCIENCES
Authors: BIANCO GIUSEPPE
Published: June 2023

This review essay discusses Larry Sommer McGrath's Making Spirit Matter: Neurology, Psychology, and Selfhood in Modern France (2020), a history of the philosophical current known as “spiritualism.” The book covers the long nineteenth century, focusing especially on the first part of the Third Republic (1870–1914), and studies how French academic philosophers confronted the discourses about human cognition and behavior that were produced by physicians—namely, physiologists and pathologists, phrenologists, neurologists, alienists, and psychiatrists. It describes how, while engaged in this confrontation, French philosophy took a peculiar shape, eventually influencing the development of some sciences—namely, psychology, which emerged progressively as a discipline at the crossroads of medicine and philosophy. In the second part of the essay, starting from a terminological analysis of a series of terms dealing with “spirit,” I consider the formation of spiritualism by adopting an approach that diverges slightly from the ones proper to history of philosophy and intellectual history. I inscribe the philosophical discourses in their contexts of emergence, paying particular attention to institutional macrostructures and their inertia. This provides another perspective on “spiritualism,” which may no longer be conceived as a current or a school; rather, it should be conceived as the effect of the conditions of possibility of academic philosophy in France. It seems to me that, starting from the beginning of the nineteenth century, because of the organization of the educational institutions, the French philosophers’ agenda consisted mainly in opposing all forms of materialism, mechanism, and determinism and in defending the legitimacy of their discipline.
Formation mechanism of texture characteristics of pork belly during stewing: focusing on the effects of myofibrillar protein modification
Authors: Wu Zhicheng , Liu Jiamin , Ruan Jinggang , Xu Min , Wang Zhaoming , Zhang Dong
Published: June 2023

The effects of stewing at a constant temperature (95 °C) for different times (45 and 90 min) on the physicochemical characteristics of lean meat (LM) and lean meat in pork belly (LMIPB) were investigated. When the stewing time was 90 min, the hardness, springiness, cohesiveness and chewiness of LMIPB were 186.35 g, 0.07 (ratio), 0.18 (ratio) and 241.90 g lower than those of LM, respectively. The chemical changes in myofibrillar protein (MP) mainly including the degree of oxidation degradation, such as carbonyl content, cross‐linked polymer and β‐sheet, were increased with prolonged stewing time. The sulfhydryl content, Zeta potential (absolute value) and α‐helix were decreased markedly. The chemical changes of MP in the LMIPB were greater than those in the LM during the stewing process. These results indicated that fat in stewing process could promote the oxidation degradation of MP in meat, and then affected the texture characteristics of meat.
Effectiveness of countermeasure for polypharmacy by multidisciplinary team review in patients with diabetes mellitus
Authors: Nishida Shohei , Kato Takehiro , Hayashi Yuichi , Yamada Shoya , Fujii Hironori , Yamada Michi , Asai Nao , Shimizu Shinya , Niwa Takashi , Iihara Hirotoshi , Kubota Sodai , Sakai Mayu , Takahashi Yoshihiro , Takao Ken , Mizuno Masami , Hirota Takuo , Kobayashi Ryo , Horikawa Yukio , Yabe Daisuke , Suzuki Akio
Published: June 2023

Aims/Introduction

Polypharmacy in diabetes patients is related to worse clinical outcomes. The aim of this study was to evaluate the usefulness of our countermeasure for polypharmacy, which combines a pharmacist check followed by a multidisciplinary team review in diabetic patients with polypharmacy.

Methods

A single‐center, retrospective observational study was conducted at Gifu University Hospital. Study participants included diabetic patients taking six or more drugs on admission to the diabetes ward between July 2021 and June 2022. Drugs which were discontinued by the present countermeasure were examined, and the number of drugs being taken by each patient was compared between admission and discharge.

Results

102 of 308 patients were taking six or more drugs on admission. The drugs being taken by these patients were evaluated by pharmacists using a checklist for polypharmacy. Eighty‐four drugs which were evaluated as inappropriate or potentially inappropriate medications by pharmacists were discontinued following the multidisciplinary team review. The median and mean number of drugs taken by the 102 patients significantly decreased from 9.0 (IQR: 8–12) and 9.26 ± 2.64 on admission to 9.0 (IQR: 6–10) and 8.42 ± 2.95 on discharge (P = 0.0002). We followed up with these patients after discontinuation of the drugs and confirmed that their clinical status had not deteriorated.

Conclusion

The present countermeasure for polypharmacy, which combines a pharmacist check based on a checklist for evaluating polypharmacy followed by a multidisciplinary team review, was useful for reducing the number of inappropriate or potentially inappropriate medications taken by diabetes patients with polypharmacy.
Managing other people's money: An agency theory in financial management industry
Authors: Papadimitriou Dimitris , Tokis Konstantinos , Vichos Georgios , Mourdoukoutas Panos
Published: June 2023

We build an active asset management model to study the interplay between the career concerns of a manager and prevailing market conditions. We show that fund managers overinvest in market‐neutral strategies, as these have a reputational benefit. This benefit is smaller in bull markets, when investors expect more managers to use high‐beta strategies, making their performance less informative about their ability than in bear markets. Consequently, fund flows that follow high‐beta strategies are less responsive to the fund's performance, and flow‐performance sensitivity is higher in bear markets than in bull markets.
Reactions to peanut at first introduction in infancy are associated with age ≥8 months and severity of eczema
Authors: Verhoeven Dirk H. J. , Herpertz Irene C. E. M. , Hol Jeroen , Klok Ted , Fleuren Suzanne P. M. , Hendriks Tom , Gerth van Wijk Roy , de Groot Hans
Published: June 2023

Background

Previous studies have shown the efficacy of the early introduction of peanut to prevent peanut allergy. Due to the exclusion of infants with sensitization to peanut, it remains unclear what the optimal timing of introduction is.

Methods

The PeanutNL study was performed in 6 pediatric allergology centers in the Netherlands. Infants referred for the clinical early introduction of peanut to prevent peanut allergy underwent skin prick tests for peanut and an oral peanut challenge at a median age of 6 months.

Results

One hundred sixty two of 707 infants (23%) who had never eaten peanut before were sensitized to peanut, of which 80 (49%) had wheals of >4 mm. Sixty seven of 707 infants (9.5%) had a positive oral challenge to peanut at first introduction. Multivariate analysis revealed that age (p < .001) and SCORAD eczema severity scores (p = .001) were significant risk factors. Introduction of peanut at ≥8 months in infants with moderate and severe eczema resulted in an increased risk (odds ratio 5.24 (p = .013) and 3.61 (p = .019), respectively) of having reactions to peanut as compared to introduction before 8 months. A family history of peanut allergy and previous reactions to egg were not identified as independent risk factors.

Conclusion

These results suggest that peanut should be introduced before the age of 8 months to reduce the risk of reactions at first exposure in infants with moderate and severe eczema. Furthermore, since children with severe eczema have the highest risk of reactions, the clinical introduction of peanut should be considered, at the latest at the age of 7 months.
Intra‐ and interpersonal factors and adolescent wellbeing during COVID‐19 in three countries
Authors: Skinner Ann T. , Kealy Carmen , Ranta Mette , Benner Aprile D. , Menesini Ersilia , Schoon Ingrid
Published: June 2023

COVID‐19 has altered adolescents' opportunities for developing and strengthening interpersonal skills and proficiencies. Using data from adolescents in Italy, the United States, and the United Kingdom, we examined the relation between internalizing symptoms assessed pre‐pandemic or when pandemic‐related restrictions were lifted (Time 1) and associated internalizing symptoms during a subsequent restrictive pandemic period (Time 2). Across all 3 countries, we found significant and consistent effect sizes in the relation between Time 1 and Time 2 internalizing symptoms. We further examined the direct and moderating impact of self‐efficacy and contextual supports for adolescents' internalizing symptoms. Higher self‐efficacy was associated with lower levels of internalizing symptoms at Time 2 in all 3 countries. Additionally, the relation between Time 1 and 2 internalizing symptoms was buffered by regulatory self‐efficacy and peer support in Italy, but in the U.S., higher levels of general self‐efficacy instead had an exacerbating effect on the relation between Times 1 and 2 internalizing symptoms. Results are discussed in the context of utilizing cross‐national datasets to examine similarities in adolescent well‐being over time and in the face of varying government responses to the pandemic.
The long term relationship between childhood Medicaid expansions and severe chronic conditions in adulthood
Authors: Brady David , Gao Manjing , Guerra Christian , Kohler Ulrich , Link Bruce
Published: June 2023

We test whether the expansions of children's Medicaid eligibility in the 1980s–1990s resulted in long‐term health benefits in terms of severe chronic conditions. Still relatively rare in the field, we use prospective individual‐level panel data from the Panel Study of Income Dynamics (PSID) along with the higher quality income measures from the Cross‐National Equivalent File (adjusting for taxes, transfers and household size). We observe severe chronic conditions (high blood pressure/heart disease, cancer, diabetes, or lung disease) at ages 30–56 (average age 43.1) for 4670 respondents who were also prospectively observed during childhood (i.e., at ages 0–17). Our analysis exploits within‐region temporal variation in childhood Medicaid eligibility and adjusts for state‐ and individual‐level controls. We uniquely concentrate attention on adjusting for childhood income. A standard deviation greater childhood Medicaid eligibility significantly reduces the probability of severe chronic conditions in adulthood by 0.05 to 0.12 (16%–37.5% reduction from mean 0.32). Across the range of observed childhood Medicaid eligibility, the probability is approximately cut in half. Greater childhood Medicaid eligibility also substantially reduces childhood income disparities in severe chronic conditions. At higher levels of childhood Medicaid eligibility, we find no significant childhood income disparities in adult severe chronic conditions.
How do we…consistently provide high‐dose granulocyte products for transfusions in neutropenic patients?
Authors: Bubar Robert , Kiss Joseph E. , Triulzi Darrell J. , D'Andrea Pam , Zilich Ashley , Kaplan Alesia
Published: June 2023

Background

The therapeutic use of granulocyte transfusions for the treatment of infections in immunocompromised patients has been a controversial practice. Randomized controlled trials suggest that benefit may be provided when a high‐dose product, defined as providing a dose of at least 0.6 × 109/kg, is offered. Here we describe the collection process and granulocyte product yield over a four‐year period at a donation center supplying a large, tertiary academic medical center.

Methods

A retrospective chart review was performed for apheresis granulocyte donations collected between 2018 and 2021 following implementation of combined G‐CSF and dexamethasone donor stimulation at our institution. Data collected includes donor demographics, G‐CSF administration timeline, pre‐collection cell counts, product yields, donor adverse events, and post‐transfusion ANC increments.

Results

A total of 269 granulocyte units were collected from 184 unique donors. The median neutrophil yield (ANC) following G‐CSF implementation was 7.5 × 1010/unit. The proportion of granulocyte products meeting or exceeding a yield of 4.0 × 1010 per unit was 96.5%. These products resulted in measurable median ANC increment of 550/μL in transfused adult patients (n = 166 transfusions).

Discussion

In order to properly assess the effectiveness of granulocyte transfusions in patients, it is necessary to ensure that the products being transfused contain an adequate granulocyte dose. This study demonstrates that the combination of G‐CSF and dexamethasone donor stimulation, followed by apheresis granulocyte collection, is safe and can reliably yield a high‐dose product. Consistent production of high‐dose units allows for better assessment of patient outcomes by reducing dosage variability.