bluuebunny/crossref_metadata_2025 huggingface dataset:
Variability assessment of PE_PGRS genes and DNA repair, replication, and recombination genes in Mycobacterium tuberculosis
Authors: Slizen V. V. , Surkova L. K. , Gurevich G. L.
Published: March 2023

The variability assessment of PE/PPE genes, as well as of DNA repair, replication, and recombination system genes may drive the concept of mechanisms of Mycobacterium tuberculosis evolution and adaptation.

The aim is to study the variability of PE_PGRS genes, 3R-system genes (DNA repair, recombination, and replication) to assess the mechanisms of evolutionary changes in M. tuberculosis.

Whole genome sequencing of M. tuberculosis 11502 (the Beijing genotype subtype B0/W148 cluster 100-32), M. tuberculosis 5005 (the Beijing genotype subtype B0/W148), M. tuberculosis 4860 (the LAM genotype) strains was performed. They were isolated from patients with newly diagnosed pulmonary tuberculosis. Genomes were uploaded to the GanBank, NCBI: M. tuberculosis 11502 – access code: CP070338.1, M. tuberculosis 5005 – access code: CP053092.1, M. tuberculosis 4860 – access code: CP049108.1. A reference genome (M. tuberculosis H37Rv; NC_000962.3) was used for genetic analysis. In the M. tuberculosis 11502 genome, 44.4 ± 6.8 % of genes (24 genes out of 54) were revealed in the mutations related to the 3R system, while in M. tuberculosis 4860– 29.6 ± 6.2 % (16 genes out of 54). In the 3R system genes, a slight shift of mutations towards replacement by adenine and thymine was revealed, while the entire genome of M. tuberculosis 11502 (compared to M. tuberculosis H37Rv) demonstrated mutations, resulting in a slight accumulation of G + C. Mutations in the 3R system genes may lead to the suboptimal activity of proteins responsible for the DNA-repair, resulting in the upsurge of mutation frequency and promoting adaptive evolution. PE_PGRS genes in the genome of M. tuberculosis 11502, 4860, and 5005 exhibited a high variability and their variability diverged among different members of this gene family. A high level of tetranucleotides CGGC was found in the majority of PE_PGRS family genes, where their proportion varied from 2.11 to 8.42 %, while an average proportion of CGGC in the M. tuberculosis genome was 1.62 %. Some genes in the M. tuberculosis genome were detected to carry no tetranucleotides CGGC (Rv0011, Rv0100, Rv0460, Rv0616A, Rv0691A, Rv0722, Rv0863, Rv0909, Rv1038c, Rv1197, Rv2347c, Rv2452c, and Rv3330c). The DNA conformation analysis at the mutation sites in the genes, associated with resistance to anti-tuberculosis drugs, showed that the secondary DNA structures were mainly formed by nucleotides CGGC, GCGC, GGG, GGGG, CTGC, and mutations occurred, predominantly, at the sites of forming secondary DNA structures (hairpins) where the redistribution of energy and charges can influence the accuracy of replication and result in replication errors and a mutation event. A number of additional factors can influence the probability of a mutation event. These are the factors that can neutralize the energy changes in the DNA secondary structures, and can affect the accuracy of DNA-repair and replication (mutations in the gyrA gene, in the 3R-system genes).
Management of rural economy in the context of noospheric worldview and sustainable development
Authors: Korbut L. V.
Published: March 2023

The article briefly reveals the genesis of the concept of “sustainable rural development”, the evolution of the rural economy, and also presents some modern approaches to the problem of rural development management. The potential contribution of the rural economy to the achievement of sustainable development goals is shown.

The author’s complex of genetic and evolutionary foundations that form the architecture of the rural economy is presented.
Management accounting in the agroindustrial complex and its automation: domestic and foreign experience
Authors: Kliukin A. D.
Published: March 2023

Approaches to the formation of the concept of «management accounting in the agroindustrial complex» in the works of domestic and foreign researchers are considered. Differences between accounting, financial and managerial types of accounting are revealed and systematized.

The directions for improving management accounting in agricultural organizations are identified, the main of which is the transition to a full automated form of accounting, which will improve the level and quality of management decisions made by the administrative and managerial personnel.
ANÁLISE DAS MANIFESTAÇÕES PATOLÓGICAS DE FACHADAS: ESTUDO DE CASO NO CONJUNTO HABITACIONAL DO IAPI, BELO HORIZONTE/MG
Authors:   , Costa Patricia Santos
Published: March 2023

As fachadas possuem suma importância para o imóvel uma vez que se danificadas podem trazer
certo desconforto estético, diminuição da durabilidade e da vida útil do edifício. Os eventos
patológicos nas fachadas são comuns no nosso dia a dia, sendo necessário conhecer, avaliar e
apontar possíveis causas da origem e as formas de tratamento. As manifestações patológicas
podem ser geradas na estrutura por erro desde a fase de projeto ou até depois de prontas,
necessitando que as pessoas envolvidas no processo possuam o mínimo de conhecimento de
como evitar que esses danos aconteçam no imóvel. Esse trabalho tem como objetivo reunir e
apresentar os principais eventos patológicos encontrados em fachadas das edificações,
utilizando trabalhos bibliográficos para exposição dos fatos e correlacionar com as patologias
encontradas durante o estudo de caso realizado no complexo do IAPI em Belo Horizonte/MG.
POR UMA ESCRITA IMUNDA
Authors: Ramos waldenilson Teixeira , Oliveira Tainá dos Santos
Published: March 2023

A fim de tecer reflexões sobre a escrita e seus processos, esta obra traz algumas das principais discussões sobre uma leitura crítica de análise de conjuntura histórica e política manifesta nos gestos escritos. Uma obra com forte base em uma perspectiva de uma psicologia social, tendo como referencial teórico contribuições importantes advindas da corrente da Filosofia da Diferença, esta obra apresenta uma apologia a uma escrita imunda. Um trabalho poético, político e filosófico sobre a experiência vivida manifesta no gesto literário e a constituição humana atravessada sobre o histórico e as condições de possibilidades subjetivas e materiais.
Reflexões e Narrativas Pedagógicas
Authors: Silva Anelize Pires Reynozo da , Coelho Simone de Oliveira , Porto Fernanda Bittencourt Novato , Pereira Marcele Martins , Pinheiro Michele da Costa , Rocha Isabella Freire Ribeiro , Santos Rosiane de Oliveira da Fonseca , Rabelo Amanda Oliveira , Leôncio Bárbara da Silva , Caccavo Romulo , Rosa Flávio Pereira , Maia Thais Vianna , Romano Rafael , Povoas Leonardo Avelino , Lacerda Fátima Kzam Damaceno de , Martins Glória da Penha Cândido , Silva Gleice Martins de Oliveira da , Souza Norma Suely Batista de , Cariello Felipe Carestiato , Paz Anderson Miguel dos Santos da , Felizardo Clayton Torres , Porto Maria Beatriz Dias da Silva Maia , Toledo-Quiroga Kemily , Nascimento Ingrid Carla Aldicéia Oliveira do , Araújo Tatiana de , Gianfaldoni Marcia Garcia , Santos Maria Alcina Porfírio dos , Medeiros Ranlig Carvalho de , Lima Tatiana Ferreira de , Ferreira Andreza Freitas
Published: March 2023

Reflexões e Narrativas Pedagógicas – Volume 2 (Série Formação Docente) é a continuidade de uma série que trata da formação docente em seus múltiplos aspectos. Nosso desejo é seguir contribuindo e potencializando, de forma democrática e gratuita, os debates no campo da Educação, apresentando por meio desta nova coletânea, artigos que discutem questões fundamentais em diferentes áreas do conhecimento.
SOLO E DESENVOLVIMENTO SUSTENTÁVEL
Authors: Lima Rafael Rodrigo Ferreira de , Araújo Fernanda Filgueiras de , Sena Géssica Santos , Ornelas Márcia Martins
Published: March 2023

O solo e o conceito de desenvolvimento sustentável são abordados de forma complementar entre si de modo a provocar a reflexão sobre o uso e ocupação do solo e o que se pode fazer para prevenir os danos a esse recurso natural.
COVID-19 nos profissionais de saúde do Hospital Dr. Alceu Melgaço Filho em Barra de São Francisco, Espírito Santo, Brasil
Authors: Piske Márcio Leandro
Published: March 2023

A publicação procura identificar as principais medidas preventivas adotadas no Hospital Dr. Alceu Melgaço Filho em Barra de São Francisco, no interior do estado do Espírito Santo, Brasil, em relação ao funcionamento dele, de forma a lidar da melhor maneira frente ao grave problema posto, buscando dessa forma identificar medidas a serem adotadas e ainda, práticas que inibissem o estresse dos profissionais que lidavam na linha de frente da covid-19.
Monitoria: reflexões de petianos multiplicadores de saberes
Authors: Espindola Bianca Araujo , Souza Karoline Gasque de , Silva Maria Solange Barbosa da
Published: March 2023

O projeto de ensino Monitoria integra o planejamento anual do Programa de Educação Tutorial (PET) Letras, da Universidade Federal do Pampa (UNIPAMPA), Campus Jaguarão, desde a criação do grupo em 2013 e foi pensado como uma alternativa de melhoria das relações teórico-práticas dos petianos. Inicialmente, cada bolsista, no período de dois anos, devia realizar monitoria em pelo menos uma disciplina do Curso de Letras. Infelizmente, com a extinção do Curso no período diurno, o projeto passou a se configurar como opcional a partir de 2016. Este projeto é tão importante, e necessário, que faz parte do planejamento do grupo até os dias atuais. A saber, há apenas um outro projeto que permanece no planejamento desde a fundação do grupo, o Capacitações PET.
Oficinas preparatórias para o ENEM: um diálogo entre os conceitos bakhtinianos e freireanos através de uma experiência no PET Letras
Authors: Lima Kéven Costa de , Martins Lucas , Macedo Maria Ingrid de
Published: March 2023

O Programa de Educação Tutorial do curso de Letras da Universidade Federal do Pampa, campus Jaguarão, iniciou suas atividades em 2013, nós, autores deste artigo, ingressamos no PET em 2017. Ao entrarmos no grupo realizamos leituras formativas e que nos inseriram no programa, dentre elas, o livro Qualidade no Ensino Superior – A Luta em defesa do Programa Especial de Treinamento (2003), da historiadora Angélica Müller, que estrategicamente serviu para apresentar maiores características do trabalho petiano.
Um curto passeio pela lusofonia através de poemas: outras leituras do Clube do Livro
Authors: Olanda Icaro Cesar Cainan da Cunha Claro
Published: March 2023

Não é tarefa fácil (re)pensar a língua, neste caso a portuguesa, sobretudo se nos alinhamos às reflexões do pensador russo Mikhail Bakhtin (1986). Para tanto, recorremos ao conceito de signo, presente na primeira epígrafe deste texto, que abre as discussões que se seguirão neste texto. Para este pensador, o signo é – e só assim – existente dentro da interação social, isto é, ele está imbuído de ideologias que circulam dentro de uma realidade material e concreta e que, consequentemente, carrega concepções de valores nos quais: “O ser refletido no signo, não apenas nele se reflete, mas também se refrata” (1986, p. 43). Ou seja, o signo é, dentre outras coisas, constituído pelo tom valorativo que cada ser impregna a ele. Imaginemos, então, (re)pensar a literatura produzida em língua portuguesa, ou melhor dito, o trabalho estético com o signo, expressa pelas distintas identidades envoltas na lusofonia.
O papel de gênero nas personagens mulheres de O conto da Aia, de Margaret Atwood
Authors: Fernandes Mariana Cavallari
Published: March 2023

O presente artigo é resultado da ampliação de minha pesquisa para o projeto Seminários Abertos, do PET Letras Jaguarão. Os papéis de gênero das personagens femininas em O conto da Aia foi o título escolhido para meu seminário e sua apresentação. A elaboração do seminário estimulou a escrita deste artigo, que conta com parte da pesquisa já desenvolvida e apresentada no seminário, bem como novas leituras e novas análises realizadas. Nesse texto, proponho uma leitura do livro O conto da Aia (1985), de Margaret Atwood, através dos papéis sociais representados por personagens mulheres na República de Gilead, analisados através da teoria de Simone de Beauvoir em O segundo sexo: fatos e mitos (1949). No campo da teoria literária, me baseio nos conceitos de personagem de Massaud Moisés e Antonio Candido, além da problematização teórica sobre narração/foco narrativo de Suzi Frankl Sperber, e na tese de doutorado de Ana Rüsche.
O direito à literatura através da poesia periférica de Sérgio Vaz
Authors: Arias Lucas da Silva
Published: March 2023

O presente artigo abordará a relação entre literatura e cultura, através da leitura e interpretação de poemas de Sérgio Vaz. Nele, exalto o poder de transformação da arte sob o olhar subversivo desse autor, considerando-o como um antropólogo autodidata, à semelhança do conceito desenvolvido por Roy Wagner no livro A invenção da cultura (1975) que apresenta a ideia de que o escritor exerce um papel de antropólogo ao inventar uma cultura em seu texto ficcional. Nesse sentido, Sérgio Vaz reinventa o olhar para a literatura produzida em espaços periféricos e de forma muito original, através dos seus textos, exalta, em muitos aspectos, uma cultura que é marginalizada. Nessa escrita, utilizo como base teórica o ensaio “Direito à literatura” de Antonio Candido e o prefácio de Heloisa Buarque de Holanda sobre a obra de Sérgio Vaz, entre outros.
APLICATIVOS MÓVEIS DESENVOLVIDOS COMO FERRAMENTAS PARA GESTÃO À ASSISTÊNCIA DE ENFERMAGEM
Authors: SCHEFFER DENISE FABIANA DE SANTANA
Published: March 2023

O uso de tecnologias móveis pelos profissionais da enfermagem está aumentando na área da
saúde, pois elas favorecem no cuidado e melhor adesão aos tratamentos de saúde, facilitando
uma maior integração entre a equipe multiprofissional e o paciente. Diante desta realidade,
esta pesquisa teve como objetivo explanar quais estudos da literatura nacional e internacional
envolve o uso de aplicativos móveis voltados para o apoio à gestão da assistência dos
profissionais de enfermagem. A metodologia empregada é a revisão bibliográfica. A análise
dos resultados mostra que o suporte profissional é o tema mais discutido no desenvolvimento
de aplicativos móveis no setor saúde. Ao analisar os pontos principais desses aplicativos,
pode-se ver que o foco onde a pesquisa em tecnologia móvel mais se beneficia é a área
assistencial. Percebe-se que a enfermagem brasileira avançou cientificamente na área da
tecnologia móvel e utilizou esse recurso para a produção de aplicações, que resultaram em
aprimoramento da prática, educação e gestão da saúde da enfermagem.
JUSTICIA ESPACIAL EN PUNTA DE MITA, NAYARIT MÉXICO: EL RESULTADO DE UNA POLÍTICA TURÍSTICA
Authors: Ramírez Hector , Pérez Varela Luis Fernando
Published: March 2023

La formación del espacio de Punta de Mita en Bahía de Banderas, Nayarit México ha estado supeditado a las decisiones de políticas públicas enfocadas en el desarrollo turístico de gran escala. Punta de Mita y, en general el municipio de Bahía de Banderas, Nayarit, se han desarrollado en la actividad turística industrial, a través de los modelos “polos de desarrollo”. S ha tenido un crecimiento de especulación inmobiliaria sin precedentes, según informes oficiales durante los últimos dos años el sector ha crecido hasta un 167%, ello condiciona en gran medida la forma en que los habitantes viven su territorio y acceden a bienes y servicios. A partir de lo anterior, el objetivo de la investigación es determinar mediante un instrumento tipo escala la consideración de los habitantes de Punta de Mita sobre la existencia de justicia espacial en su localidad. Los resultados los relacionamos con las formas en que las injusticias se manifiestan a partir de la implementación de las políticas turísticas en Punta de Mita, Nayarit como parte del proceso de desarrollo y producción social urbana. El fundamento teórico de la investigación son las principales discusiones conceptuales entorno a la justicia espacial y el análisis de política pública, esto es, la exploración de la relación entre el espacio producido y la vida económico-política del territorio de estudio. Como elemento metodológico fundamental se desarrolló un índice de justicia espacial a partir de 4 variables fundamentales 1) acceso a bienes y servicios de la población 2) Las relaciones de la población con el entorno sociopolítico 3) la atención a las demandas y provisión institucional 4) características socioeconómicas de la población. A partir de la construcción del índice, se elaboró una matriz para buscar una correlación entre las variables, el trabajo estadístico se realizó utilizando el software SPSS 25. Los resultados indican la existencia de injusticia espacial en Punta de Mita Nayarit vista como la diferencia en las oportunidades para vivir el espacio urbano compartido; mientras algunas personas gozan de los recursos, infraestructura y garantías de seguridad, otras sufren las consecuencias de habitar un entorno turístico de gran escala variando sus actividades en busca de supervivencia. Se propone a la justicia espacial como un elemento central en la consideración de diseño de políticas de desarrollo, pues la planeación de este no solo debe considerar elementos económicos y de crecimiento en competitividad como destino, sino, considerar elementos socioespaciales para lograr condiciones más justas para los habitantes de Punta de Mita.
PENINGKATAN KAPABILITAS UMKM YANG TERGABUNG DALAM KULINER WISMA SIG DALAM MENINGKATKAN LAYANAN PADA PENGUNJUNG
Authors: Dzulquarnain Abi Hanif , Kirono Indro
Published: March 2023

Layanan di tempat makan (Pujasera) memiliki keunikan sendiri. Keunikan disini maksudnya adalah ada banyak elemen yang perlu dilibatkan agar menyampaikan layanan tersampaikan kepada pelanggan. Penekanannya tidak hanya menyediakan menu yang original dan memiliki kekhasan cita rasa dan sajian masakan, namun juga aspek seperti permainan harga, diskon, dan promo, tata letak ruang (interior), layanan penunjang seperti WIFI, hiburan musik dan lainnya. Sajian makanan menjadi salah satu kunci berhasilnya penjual ini dalam meningkatkan penjualan. Salama era pandemic masih berlangsung, kunjungan di Kuliner Wisma sangat minim, sehingga penjual pada tiap stan memerlukan strategi bagaimana meningkatkan animo kembali masyarakat dalam menikmati sajian di kuliner di tempat ini. Kegiatan menekankan pada pemberian pemahaman dan pendekatan personal aplikatif pada tiap stan dengan menekankan pada pemahaman sajian makanan (platting, garnish, utensil used, dan lainnya). Sebanyak 28 stan makanan tergabung dalam kuliner wisma dilibatkan dalam proses selama kurang lebih 3 bulan. Hasil kegiatan menunjukkan adanya perubahan signifikan dalam tampilann sajian makanan dan minuman yang mengedepankan konsep pujasera modern yang memperhatikan tidak hanya cita rasa namun estetik makanan tersebut. survei kepuasan pelanggan dilakukan sebangai bentuk evaluasi pengunjunh terhadap hsil kegiatan, dimana hasil survei ini menunjukkan respon positif dari masyarakat.
PENYULUHAN BERBICARA DENGAN TETANGGA DI LINGKUNGAN KRAJAN TIMUR KABUPATEN JEMBER
Authors: Mijianti Yerry , Tamami Badrut
Published: March 2023

Masyarakat di Rukun Tetangga 2 Lingkungan Krajan Timur Kelurahan Sumbersari Kecamatan Sumbersari Kabupaten Jember Provinsi Jawa Timur terdiri dari etnis Cina, suku Jawa, dan suku Madura. Masing-masing memiliki norma budaya untuk dianut saat berinteraksi. Masalah yang ditemukan pada ibu-ibu di RT 2 Lingkungan Krajan Timur adalah kurangnya kemampuan komunikasi bertetangga dalam kegiatan bermasyarakat. Kegiatan ini dilakukan dengan enam tahapan, yaitu observasi, perumusan masalah, studi literature dan studi lapangan, pembuatan materi, sosialisasi, serta feedback. Penyuluhan terhadap ibu-ibu RT 2 Lingkungan Krajan Timur dilakukan menggunakan metode sosialisasi secara tatap muka langsung. Ibu-ibu di RT 2 Lingkungan Krajan Timur Kelurahan Sumbersari Kecamatan Sumbersai Kabupaten Jember Provinsi Jawa Timur dapat menerapkan kegiatan komunikasi antartetangga sesuai dengan kesantunan berbahasa, konsep dan etika bertetangga, serta memiliki kemampuan menyelesaikan konflik antartetangga sesuai dengan materi yang telah disampaikan oleh tim pengabdi dari Universitas Muhammadiyah Jember.
MEMBANGUN EKONOMI MELALUI UMKM BUCKET UANG DAN JAJAN DENGAN POTENSI DI ERA DIGITAL DESA BALONGGARUT
Authors: Ariprabowo Tri
Published: March 2023

Dengan perkembangan teknologi manfaat penggunaan internet terasa bagi para pemakainya. Beberapa orang ketergantungan dengan adanya internet, termasuk aktivitas Usaha Mikro Kecil dan Menegah (UMKM). Usaha mikro, kecil dan menengah (UMKM) merupakan salah satu bidang usaha yang dapat berkembang dikalangan masyarakat. Usaha mikro, kecil dan menengah (UMKM) menjadi wadah yang baik untuk menciptakan lapangan pekerjaan yang direncanakan oleh pemerintah, swasta dan pelakunya usaha perorangan. Tujuan Penelitian ini yaitu meningkatkan perekonomian melalui UMKM Buket Bunga di Desa Balonggarut. Hasil dari Program ini juga dapat membantu Warga Balonggarut dalam membangun ekonomi melalui UMKM Buket Bunga dengan potensi di Era Digital Desa Balonggarut.

Kata Kunci: Pemberdayaan Perempuan, UMKM, Pemasaran Digital

ABSTRACT

With the development of technology, the benefits of using the internet are felt for the users.Some peopleare dependent on the internet, including the activities of Micro, Small and Medium Enterprises (MSMEs). Micro, small and medium enterprises (MSMEs) are one of the business fields that can developamong the community. Micro, small and medium enterprises (MSMEs) are a good place to create jobs planned by the government, private sector and individual business actors. The aim of this research is toimprove the economy through Flower Bucket UMKM in Balanggarut Village. The results of this programcan also help Balanggarut

 

residents in developing the economy through Flower Bucket MSMEs with potential in the Digital Era of Balanggarut Village.

Keyords: Women Empowerment, UMKN, Digital Marketing
SOSIALISASI PENCEGAHAN STUNTING MELALUI PELATIHAN PENGOLAHAN EKADO DI DESA GINTUNGAN, KECAMATAN KEMBANGBAHU, KABUPATEN LAMONGAN
Authors: Prayitno Sutrisno Adi , Utami Dwi Retnaningtyas , Maulida Safitri Nur , Dewi Intan Iriani , Oktaviani Elfira
Published: March 2023

Permasalahan gizi buruk serta stunting merupakan hal yang perlu ditanggulangi di Indonesia. Pengetahuan bahan makanan yang bergizi masih berperan dalam pencegahan kenaikan angka stunting. Beragam pangan dapat diaplikasikan ke dalam olahan makanan untuk balita. Ketidaktahuan orang tua bayi dalam penyajian makanan sehat dan bergizi baik menjadikan ketersediaan makanan bagi balita hanya berdasarkan jumlah saja tanpa melihat komposisi gizi makanan tersebut. Oleh karena itu, tujuan dari kegiatan pengabdian masyarakat ini adalah untuk meningkatkan pengetahuan dan pemahanan masyarakat terkait pencegahan stunting dan peningkatan status gizi anak melalui diversifikasi olahan berbasis pangan yang memiliki protein tinggi. Hasil dari kegiatan diskusi adalah peserta secara keseluruhan dapat mengetahui beragam bahan makanan sehat bergizi yang dapat digunakan dalam pencegahan stunting, mampu mengolah ekado secara sederhana dengan tepat, hingga pengemasan dan penyimpanan. Berdasarkan hasil survey, didapatkan 21.75% peserta menyatakan sudah pernah memperoleh penyuluhan stunting dan 67.25% peserta belum pernah memperoleh penyuluhan tentang stunting, serta seluruh peserta (100%)  menyatakan puas dan memeroleh manfaat dari kegiatan PKM.
PENINGKATAN KAPABILITAS ’’ENTREPRENEURSHIP OF SMECTRA’’ DALAM MENGHADAPI ERA INDUSTRI 5.0
Authors: Kurniawan Aries , Komara Beni Dwi , Maziyah Elif Nashikhatul , Soelistya Djoko
Published: March 2023

SMK NU Gresik has 736 students with the number of graduations reaching 225 per year. However, the development of IT (Information Technology) and globalization has influenced companies to innovate in industrial automation. As a result, less job opportunities and reduced absorption of SMK NU Gresik graduates in IDUKA (Industrial and Business World). The location plan for the implementation of the Community Partnership Program (PKM) is at the Gresik NU SMK which has the potential to carry out entrepreneurial development activities and business development.

In addition, SMK NU Gresik has the potential to become a school that produces entrepreneurs by embedding entrepreneurial concepts holistically or involving cognitive, affective and psychomotor domains. Entrepreneurship lessons should be provided with a larger and more dominant portion when compared to other subjects that are oriented towards cognitive intelligence.

The objectives of implementing PKM activities are; 1. Prepare students to enter the workforce and business world and develop a professional attitude. 2. Prepare students to be able to choose careers, be competent and able to develop themselves. 3. Preparing the middle level workforce to fill the needs of industry and the world of work at this time and in the future. 4. Prepare graduates to become productive, adaptive and creative citizens with a science and technology perspective. Through coaching in this PKM program, it can improve entrepreneurial spirit and skills so that they are ready to enter the industrial world and the business world.
“Ruam Kâbil-i Tedavi midir? Ruama Karşı Aşı ve Serum İstihsar ve Tatbiki Mümkün müdür?” Başlıklı Ayrıbasımın Değerlendirilmesi Üzerine Bir Araştırma
Authors: KARA Abdullah , YÜKSEL Erhan , YÜKSEL Özlem , ÇAVDAROĞLU Mustafa
Published: March 2023

Ruama dair Türkiye’de ilk bilgilere Askerî Baytar Mektebinin kurucusu Veteriner Hekim Godlewsky’nin mektuplarında rastlanmakta olup, hastalığın ilk olarak 1912 yılında İstanbul’da teşhis edildiği bildirilmiştir. Ruam ile ilgili bilimsel araştırmalara Askerî Veteriner Hekim ve Bakteriyolog Osman Nuri Eralp (1877-1940), Veteriner Hekim Ahmet Bey (1890-1928) ve Veteriner Hekim Hüdâi Beyin (1898-1928) öncülük ettiği görülmektedir. Bu çalışmada Askerî Veteriner Hekim ve Bakteriyolog Osman Nuri Eralp, Veteriner Hekim Ahmet Bey ve Veteriner Hekim Hüdâi Bey tarafından yürütülen çalışmalar ve sonuçlarının derlendiği, Arap harfleriyle yayımlanmış “Ruam kâbil-i tedavi midir? Ruama karşı aşı ve serum istihsar ve tatbiki mümkün müdür?” başlıklı ayrı basımın transliterasyonu ve değerlendirilmesi amaçlanmıştır. Yapılan transliterasyon ve içerik değerlendirmesine dayanarak; ayrıbasımın, Türkiye’de ruam hastalığı ile ilgili çalışmalar açısından orjin teşkil etmesi ve dönemin bilimsel çalışma prensiplerini yansıtması açısından genel de bilim tarihi araştırmaları özel de ise veteriner hekimliği tarihi açısından önemli olduğu ileri sürülebilir.
IDENTIFYING POTENTIAL ZONES FOR ECOTOURISM DEVELOPMENT IN BATTICALOA DISTRICT OF SRI LANKA USING THE GIS-BASED AHP SPATIAL ANALYSIS
Authors:   University of Malaya, Faculty of Arts and Social Sciences, Department of Geography, Kuala Lumpur, Malaysia, PATHMANANDAKUMAR Vyddiyaratnam , GOH Hong Ching ,   University of Malaya, Faculty of Built Environment, Department of Urban & Regional Planning, Kuala Lumpur, Malaysia, CHENOLI Sheeba Nettukandy ,   University of Malaya, Faculty of Arts and Social Sciences, Department of Geography, Kuala Lumpur, Malaysia
Published: March 2023

Ecotourism makes a significant contribution to long-term development. However, a spatial analysis-based multi-criteria process has been widely used in ecotourism development planning. Batticaloa district is one of the tourism hotspots in the country which distinctive views play a significant role in fostering the potential for ecotourism. However, no specific study or planning has been carried out to identify appropriate zones for ecotourism development. This study attempts to identify suitable zones for ecotourism development in Batticaloa District. In this research AHP method was used in GIS environment. Five thematic layers such as landscape, protected area, topography, accessibility, and community characteristics were given appropriate weights and integrated into the GIS through the weighted overlay analysis. Accordingly, five potential ecotourism zones were identified in the study area. The research revealed that the area very suitable for ecotourism development is largely distributed in the northern, western, and south-western parts of the Batticaloa district. Finally, 12.53% of the land area of the District falls under the “very suitable to extremely suitable" area for ecotourism development. The findings of this study can assist tourism planners and the government in precisely selecting locations for ecotourism development and relieving pressures on the region's tourism demand.
The effect of implementing technology in formative assessments to ensure student learning in higher education English literature courses after COVID-19
Authors: Awajan Nasaybah Walid
Published: March 2023

This study aims to show how formative assessment that is assisted by technology can improve student learning in English literature courses in higher education. Moreover, it explores how the use of technology could help implement formative assessment by the instructors to assure student learning in English literature courses in an efficient and timely manner. Formative assessment is somewhat new for higher education instructors, especially those who teach English literature. Applying this type of assessment is, unfortunately, not easy and the results are not always ideal. Nevertheless, to reach the goals of the study, a quantitative method is distributed to 50 English literature instructors from higher educational institutions that recently started implementing technology in their formative assessments. The significance of the study lies in the fact that the study is conducted in a region where formative assessment has recently been used in education, specifically in higher education English literature courses. The contribution also lies in how technology can help implement formative assessment, overcome any obstacles, and thus ensure student learning. The findings of the study show significant awareness of formative assessment in higher education, and especially among instructors of English literature. The findings also indicate that implementing technology with formative assessments enhances students’ learning in English literature course in higher education after COVID-19.
An asymptotic homogenization formula for complex permittivity and its application
Authors: MİTYUSHEV Vladimir , GRİC Tatjana , ZHUNUSSOVA Zh. Kh. , DOSMAGULOVA Karlygash
Published: March 2023

The $\mathbb R$-linear boundary value problem in a multiply connected domain on a flat torus is considered. This problem is closely related to the Riemann-Hilbert problem on analytic functions. The considered problem arises in the homogenization procedure of random media with complex constants which express the permittivity of components. A new asymptotic formula for the effective permittivity tensor is derived. The formula contains location of inclusions in symbolic form. The application of the derived formula to investigation of the morphology of the tumor cells in disordered biological media is discussed.
Mối quan hệ giữa các Hiệp định Thương mại Ưu đãi và Đầu tư Trực tiếp Nước ngoài
Authors: Phan Ngoc
Published: March 2023

Nghiên cứu này xem xét tác động của các Hiệp định Thương mại Ưu đãi (PTA) đối với dòng vốn Đầu tư Trực tiếp Nước ngoài (FDI). Kết quả thực nghiệm cho thấy rằng FDI thu được từ thương mại ưu đãi đang tăng lên theo quy mô thị trường của các đối tác thương mại ưu đãi nhưng không phải do sự gần gũi về kinh tế và địa lý của họ với nước sở tại. Mối liên hệ giữa PTA và dòng vốn FDI chỉ tồn tại ở các nước thu nhập trung bình và cao, trong khi mối quan hệ này đã biến mất đối với các nước thu nhập thấp. Nghiên cứu này khuyến nghị các quốc gia nên cung cấp các lợi ích khác nhau liên quan đến thương mại cho các nhà đầu tư nước ngoài để thu hút dòng vốn cao hơn
Rules and statistics: What if it’s both? A basic computational model of statistical learning in reading acquisition
Authors: Schmalz Xenia
Published: March 2023

Orthographies contain statistical regularities, such as a systematic relationship between written word forms and their pronunciations. Based on this observation, reading researchers have proposed a tight link between reading acquisition and statistical learning ability, and a statistical learning deficit as a possible cause of developmental dyslexia. The empirical evidence for a link between statistical learning ability and reading ability is weak, and no existing theoretical framework is complete enough to be implementable as a computational model. I present a basic computational model which performs a simple statistical learning task. A variable rule learning mechanism supplements the statistical learning mechanism. Simulations varying this parameter, along with an additional encoding and uncertainty parameters, show that individual differences in statistical learning performance can occur without any changes to the efficiency of the statistical learning mechanism. This explains the apparent paradox, that knowledge of statistical regularities seems to be critical for efficient reading, but that the empirical link between statistical learning ability and reading ability is tenuous.
Differential expression of NFE2L3 in colorectal cancer.
Authors: Mamoor Shahan
Published: March 2023

Cancer is a leading cause of death and colorectal cancer is among the most lethal cancers (1, 2). We mined published and public microarray datasets (3, 4) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with colorectal cancer (CRC). We found significant differential expression of the gene encoding nuclear factor (erythroid-derived 2)-like 3, NFE2L3, when comparing colorectal tumors to the tissue of origin, the colon. NFE2L3 mRNA was present at significantly higher quantities in tumors of the colon as compared to normal colorectal tissue. Analysis of human survival data revealed that expression of NFE2L3 in rectal tumors was correlated with overall survival in patients with rectal cancer. NFE2L3 expression changes may be important for the initiation or progression of human CRC.
Nonequilibrium physics in two and three states (Chapter 2)
Authors: Zuckerman Daniel
Published: March 2023

This chapter uses the simplest systems, with two or three discrete states, to study core elements of nonequilibrium science. Two-state biochemical models include (idealized) protein folding and conformational switches. Using the standard differential-equation description of chemical kinetics, the chapter explains both equilibrium and nonequilibrium steady states. The same framework illustrates the fundamental process of relaxation from initial state populations to the appropriate steady state defined by the model. Additional biochemical examples include simple binding and the Michaelis-Menten model of catalysis. The chapter also describes basic computational approaches for studying differential equations and for simulating discrete-state stochastic processes.
Logistic Regression Collaborating with AI Beam Search
Authors: Tom Daniel M.
Published: March 2023

We systematically explore the universe of all models using AI search methods. We automate much of the data preparation and testing of each model built along the way. The result is a method and system that generate superior production ready logistic regression models, beating an industry standard consumer credit risk score, GBM and NN ML models. We also incorporate into our system a method to eliminate disparate impact used by the FRB and the FTC.
Differential expression of KPNA2 in colorectal cancer.
Authors: Mamoor Shahan
Published: March 2023

Cancer is a leading cause of death and colorectal cancer is among the most lethal cancers (1, 2). We mined published microarray datasets (3, 4) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with colorectal cancer (CRC). We found significant differential expression of the gene encoding karyopherin alpha 2 (importin alpha 1), KPNA2, when comparing colorectal tumors to the tissue of origin, the colon. KPNA2 mRNA was present at significantly higher quantities in tumors of the colon as compared to normal colorectal tissue. Analysis of human survival data revealed that expression of KPNA2 in rectal tumors was correlated with overall survival in patients with rectal cancer. KPNA2 expression changes may be important for the initiation or progression of human CRC.
Dynamic Structural Equation Models with Binary and Ordinal Outcomes in Mplus
Authors: McNeish Daniel , Somers Jennifer , Savord Andrea
Published: March 2023

Intensive longitudinal designs are increasingly popular, as are dynamic structural equation models (DSEM) to accommodate unique features of these designs. Many helpful resources on DSEM exist, though they focus on continuous outcomes while categorical outcomes are omitted, briefly mentioned, or considered as a straightforward extension. This viewpoint regarding categorical outcomes is not unwarranted for technical audiences, but there are non-trivial nuances in model building and interpretation with categorical outcomes that are not necessarily straightforward for empirical researchers. Furthermore, categorical outcomes are common given that binary behavioral indicators or Likert responses are frequently solicited as low-burden variables to discourage participant non-response. This tutorial paper is therefore dedicated to providing an accessible treatment of DSEM in Mplus exclusively for categorical outcomes. We cover the general probit model whereby the raw categorical responses are assumed to come from an underlying normal process. We cover probit DSEM and expound why existing treatments have considered categorical outcomes as straightforward extensions of the continuous case. Data from a motivating ecological momentary assessment study with a binary outcome are used to demonstrate an unconditional model, a model with disaggregated covariates, and a model for data with a time trend. We provide annotated Mplus code for these models and discuss interpretation of the results. We then discuss model specification and interpretation in the case of an ordinal outcome and provide an example to highlight differences between ordinal and binary outcomes. We conclude with a discussion of caveats and extensions.
Revisiting “Importance of domain-specific metacognition for explaining beliefs about politicized science: The case of climate change“ – Evidence from a cross-cultural sample
Authors: Said Nadia , Frauhammer Luna T. , Huff Markus
Published: March 2023

Having accurate knowledge about climate change has been shown to influence climatechange attitudes and behavior. However, due to an increase in online mediaconsumption, people are also confronted with much misinformation about climatechange. It is thus crucial that people use valid cues to infer whether information is trueor false, when to update their beliefs, and to make informed decisions. One such cuecould be meta-knowledge, usually measured as the confidence one has in one’sknowledge. Recent findings show that higher confidence in knowledge about climatechange is associated with stronger beliefs that humans are causing climate changeand with perceptions that climate change is risky. We aim to extend and replicate thisfinding with improved methods (larger sample sizes, four instead of only two attitudes,U.S. and German samples), allowing us not only to put previous findings on a firmerbasis, but also to conduct cross-cultural comparative analyses.To this end, weassessed whether confidence in climate change knowledge as well as metacognitivesensitivity (insight into the accuracy of one’s knowledge), is related to climate changeattitudes for Germany (N = 1110, representative) and the US (N = 898, representative).Results show that, rather than confidence, higher insight into the accuracy of one’sknowledge was positively related to the climate change attitudes for the Germansample. In contrast, for the US, higher confidence was predictive of climate changeattitudes but only for participants with above-chance performance in the climatechange knowledge test. Our results emphasize the important role of metacognitiveabilities as predictor of climate change attitudes while also highlighting cross-culturaldifferences.
Determinants of victimization in patients with severe mental illness: results from a nation-wide cross-sectional survey in the Netherlands
Authors: Kamperman Astrid Mariska , Henrichs Jens , Zarchev Milan , Willemsen Sten , Lesaffre Emmanuel , Swildens Wilma , Nijssen Yolanda , Kroon Hans , van Schaik Anneke , van der Gaag Mark , Delespaul Philippe , van Weeghel Jaap , van de Mheen Dike , Bogaerts Stefan , Mulder Cornelis
Published: March 2023

We aimed to examine determinants of criminal victimization (i.e. both personal and property crime victimization) in outpatients with severe mental illness.Data was collected using a multisite epidemiological survey including a random sample of 956 adult outpatients with SMI. Data on 12-month victimization prevalence and frequency were obtained using the victimization scale of the Dutch Crime and Victimization Survey. Demographic characteristics, clinical diagnosis, psychosocial functioning, drug use and alcohol abuse over the past 12 months, co-morbid PTSD diagnosis, physical abuse, physical neglect and sexual abuse in childhood, perpetration of violence over the past 12-months, and anger disposition were assessed as determinants. Univariable and multivariable hurdle regression analyses were conducted to test associations of the potential determinants with victimization prevalence and frequency. We found that different sets of demographic and clinical characteristics were associated with personal and property crime victimization. Clinical characteristics were more pronounced regarding personal crime victimization. In the multivariable model, presence of psychotic disorder, drug use, childhood physical and sexual abuse, and recent violent perpetration were associated with the 12-month prevalence or frequency rate of personal crime victimization. Native Dutch and divorced patients were more at risk as well. Next to this being employed, poor social functioning, having perpetrated a violent crime, as well as alcohol abuse and recent drug use were all significantly related to property crime prevalence or frequency rate in the multivariable model.
Rethinking Climate Change Vulnerabilities in light of the COVID-19 Crisis: Illustrations through Conspiracy Theories and Diversity Issues
Authors: GRATON Aurélien , Sarrasin Oriane , Klein Olivier , Schuldt Jonathon
Published: March 2023

Scholars have noted several connections between the COVID-19 pandemic and the climate crisis, ranging from the material influence of the pandemic on climate change processes (e.g., how lockdowns temporarily lowered climate emissions) to the similar ways the crises have been managed. Both crises are also global in scope, have exerted a significant toll in human lives and require major changes in our lifestyles. However, while collective responses to the COVID-19 were rapid and concerted, efforts to address climate change continue to be met with resistance. In this article, we investigate the social vulnerabilities common to both crises and the lessons that social scientists interested in climate change, and psychologists in particular, can take away from the pandemic. We focus on two broad topics of contemporary interest that lay bare social vulnerabilities of the coronavirus pandemic – conspiracy theories and racial and ethnic inequities – to highlight the ways that understanding psychological processes associated with the pandemic can help inform more efficient climate policies. We end by discussing recommendations as well as a framework to guide the application of psychological science findings to help address climate change.
Are blind individuals immune to bodily illusions? Somatic rubber hand illusion in the blind revisited
Authors: Radziun Dominika , Korczyk Maksymilian , Szwed Marcin , Ehrsson H. Henrik
Published: March 2023

Multisensory awareness of one’s own body relies on the integration of signals from various sensory modalities such as vision, touch, and proprioception. But how do blind individuals perceive their bodies without visual cues, and does the brain of a blind person integrate bodily senses differently from a sighted person? To address this question, we aimed to replicate the only two previous studies on this topic, which claimed that blind individuals do not experience the somatic rubber hand illusion, a bodily illusion triggered by the integration of correlated tactile and proprioceptive signals from the two hands. We used a larger sample size than the previous studies and added Bayesian analyses to examine statistical evidence in favor of the lack of an illusion effect. Moreover, we employed tests to investigate whether enhanced tactile acuity and cardiac interoceptive accuracy in blind individuals could also explain the weaker illusion. We tested 36 blind individuals and 36 age- and sex-matched sighted volunteers. The results show that blind individuals do not experience the somatic rubber hand illusion based on questionnaire ratings and behavioral measures that assessed changes in hand position sense toward the location of the rubber hand. This conclusion is supported by Bayesian evidence in favor of the null hypothesis. Tactile acuity was not correlated with illusion measures in either group, but cardiac interoceptive accuracy was negatively correlated with questionnaire ratings of illusion strength in the sighted group. The findings confirm that blind individuals do not experience the somatic rubber hand illusion, indicating that lack of visual experience leads to permanent changes in multisensory bodily perception. Taken together, this study suggests that changes in multisensory integration of tactile and proprioceptive signals, possibly combined with more accurate interoception, may explain why blind individuals appear “immune” to the nonvisual version of the rubber hand illusion.
Impacts of Confinement on Mental Health and Health Behaviours of Individuals with Multimorbidity during Covid-19 Pandemic
Authors: Chauvin Valerie , Villarino Resti Tito , Bernard Paquito , Yazbek Hanan , Kern Laurence , Hokayen Marie , Morvan Yannick , Mattar  , Gayatri KOTBAGI , Rizk Melissa , Baillot Aurelie , Romain Ahmed Jerome
Published: March 2023

Background: Confinement and its possible impact on lifestyle make people with multimorbidity more vulnerable to modifications of their mental health and health behaviours that could persist beyond confinement.Objective: To understand the mental health status and health behaviour modifications among individuals with multimorbidity during and post COVID-19 confinement.Methods: Longitudinal multinational cohort study consisting of two online questionnaires with its first wave taken place during the first COVID-19 confinement (May 2020) and its second wave post-deconfinement (November 2020). Including 559 (wave 1) and 144 (wave 2) participants with an average age of 34.30±12.35 and 36.21±13.07 years old. Mostly females living in Canada, France, India and Lebanon. Results: The prevalence of multimorbidity was 27.68%. During confinement, people with multimorbidity were 2 to 3 times more likely to experience psychological distress, depressive symptoms, increased stress or isolation, and the prevalence of stress and psychological distress increased post-deconfinement. Health behaviours were also modified during confinement with people with multimorbidity being more likely to reduce their physical activity and increased their fruit and vegetable consumption. Post-deconfinement, people with multimorbidity had increased sleep problems. Also, regardless of multimorbidity status, sexual desire continuously decreased post-deconfinement. Conclusion: Mental health and health behaviours modifications occurred during the COVID-19 confinement period and people with multimorbidity were more severely impacted on these two outcomes than those without multimorbidity, indicating a need for a more adapted approach of care to future confinement periods or pandemic for this population.