bluuebunny/crossref_metadata_2025 huggingface dataset:
Patients’ Experiences of Using Skin Self-monitoring Apps With People at Higher Risk of Melanoma: Qualitative Study (Preprint)
Authors: Habgood Emily , McCormack Christopher , Walter Fiona M , Emery Jon D
Published: July 2020

BACKGROUND

Melanoma is the fourth most commonly diagnosed cancer in Australia. Up to 75% of melanomas are first detected by patients or their family or friends. Many mobile apps for melanoma exist, including apps to encourage skin self-monitoring to improve the likelihood of early detection. Previous research in this area has focused on their development, diagnostic accuracy, or validation. Little is known about patients’ views and experiences of using these apps.

OBJECTIVE

This study aims to understand patients’ views and experiences of using commercially available melanoma skin self-monitoring mobile apps for a period of 3 months.

METHODS

This qualitative study was conducted in two populations: primary care (where the MelatoolsQ tool was used to identify patients who were at increased risk of melanoma) and secondary care (where patients had a previous diagnosis of melanoma, stages T0-T3a). Participants downloaded 2 of the 4 mobile apps for skin self-monitoring (SkinVision, UMSkinCheck, Mole Monitor, or MySkinPal) and were encouraged to use them for 3 months. After 3 months, a semistructured interview was conducted with participants to discuss their experiences of using the skin self-monitoring mobile apps.

RESULTS

A total of 54 participants were recruited in the study, with 37% (20) of participants from primary care and 62% (34) from secondary care. Interviews were conducted with 34 participants when data saturation was reached. Most participants did not use the apps at all (n=12) or tried them once but did not continue (n=14). Only 8 participants used the apps to assist with skin self-monitoring for the entire duration of the study. Patients discussed the apps in the context of the importance of early detection and their current skin self-monitoring behaviors. A range of features of perceived quality of each app affected engagement to support skin self-monitoring. Participants described their skin self-monitoring routines and potential mismatches with the app reminders. They also described the technical and practical difficulties experienced when using the apps for skin self-monitoring. The app’s positioning within existing relationships with health care providers was crucial to understand the use of the apps.

CONCLUSIONS

This study of patients at increased risk of melanoma highlights several barriers to engagement with apps to support skin self-monitoring. The results highlight the wide-ranging and dynamic influences on engagement with mobile apps, which extend beyond app design and relate to broader contextual factors about skin self-monitoring routines and relationships with health care providers.
TRANSDERMAL DELIVERY OF AN EFFECTIVE NONSTEROIDAL ANTI-INFLAMMATORY DRUGS FOR PAIN MANAGEMENT IN ARTHRITIS
Authors: D MANJULA , RAJ ABHISHEK , JENITA J JOSEPHINE LENO , BANU SHANAZ
Published: July 2020

Objective: The current research work has been carried out with the aim to develop a transdermal gel formulation of fenoprofen (a nonsteroidal anti-inflammatory drug used to treat pain associated in arthritis) which would overcome the gastrointestinal-related problems associated with oral administration of the drug. The present study aims at formulating transdermal gels using different concentrations of Carbopol, hydroxypropyl methylcellulose (HPMC), sodium alginate, and guar gum.

Methods: The formulated gels were subjected for various evaluation tests such as clarity, homogeneity, viscosity, drug content, pH, spreadability, and in vitro permeation studies. Drug–polymer interaction was studied by Fourier transmission infrared (FTIR) and differential scanning calorimetry (DSC). The in vitro permeation studies were performed in phosphate buffer 7.4 using Franz diffusion cell.

Results: The FT-IR and DSC studies showed no chemical interaction between drug and polymers used. All the formulated gels showed acceptable physical properties with respect to clarity, homogeneity, viscosity, drug content, pH, and spreadability. Among all the gel formulations, Carbopol gels containing fenoprofen showed good drug release compared to HPMC, sodium alginate, and guar gum. Optimized formulation was further subjected to kinetic studies which showed Higuchi model of drug release. The same formulation showed significant anti-inflammatory and analgesic activity, tested in Wistar albino rats. No signs of erythema, edema, flushing, and papules were observed when skin irritation test was performed. Stability studies under accelerated condition showed satisfactory results for the optimized formulation.

Conclusions: Thus, it was concluded from the results that the optimized formulation showed controlled and slow drug delivery. Animal studies were significant at p<0.05 and 0.001. The selected formulation was stable at various ambient temperatures.
INSIGHT INTO BASELINE TROUBLES AND PROBLEM RESOLUTIONS IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
Authors: D ATOLE , UA DEOKATE
Published: July 2020

For pharmaceutical industry, HPLC is more than 40 years old. Even after instrumental advancements in HPLC problems still arise, troubleshooting still comes. HPLC is the main stay of analytical section nowadays in pharmaceutical industry whether it is API industry or formulation plant. Best approach for troubleshooting HPLC problems is going with systematic way. At the start of quantitative chromatographic analysis, the first parameter of paramount importance is baseline, especially for measuring the area of any given peak. Baseline usually suffers from these errors, namely, high baseline drift, periodic baseline fluctuation, and spikes. This article aims at suggesting some working methodologies which will resolve as well as avoid cases of such errors and failures.
THE EVALUATION OF INCREASED SERUM CREATININE DUE TO THE USE OF ACEI THERAPY ON HYPERTENSION PATIENTS IN UNDATA HOSPITAL, PALU, CENTRAL SULAWESI PROVINCE
Authors: RUMI AMELIA , M RADI DAN NURHALIMA
Published: July 2020

Objective: This study aims to determine the mean baseline value and the evaluation of serum creatinine in hypertensive patients after receiving angiotensin-converting enzyme inhibitor (ACEi) antihypertensive therapy for the first time in a span.

Methods: This study used a cross-sectional design with a prospective approach by carrying out laboratory tests of serum creatinine using the Jaffe method using the patient’s blood at the beginning as the baseline value and a month after treated with (ACEi) antihypertensive therapy as the evaluation value. The results of this research were analyzed using the SPSS statistical paired test to observe the occurrence of increased serum creatinine as the aftereffect of ACEi antihypertensive treatment. The total of samples which met the inclusion and exclusion criteria was 30 patients.

Results: The findings showed an increase of serum creatinine value, where statistics displayed the significant value of **P below 0.05 with the mean baseline value of 0.98 and an average evaluation value of 1.14. When examined clinically, despite the increase of serum creatinine, the patient’s kidney function is still within a normal range.

Conclusion: The study concluded that the increase of serum creatinine value can become one’s indicators of decreasing kidney function.
IN VITRO SCREENING AND CORRELATION OF ETHANOLIC PEEL EXTRACTS OF PUNICA GRANATUM AND CITRUS SINENSIS WITH RESPECT TO ANTIOXIDANT AND ANTIRADICAL ACTIVITY
Authors: V SONTAKKE AJIT , S HENDRE ANUP , R PATIL SANGITA
Published: July 2020

Objective: The objective of this study is to evaluate the effect of the ethanolic peel extracts of Punica granatum and Citrus sinensis on total phenolics, total antioxidants, and radical scavenging activities using different in vitro models.

Methods: Pomegranate and orange fruits at the maturity stage were manually peeled, washed, and air dried before extraction. Dried peels were grinded, weighed, and extracted with 95% ethanol and were used for in vitro analysis. Different concentrations of extracts for each peel were prepared. Total phenolics content, total antioxidant capacity, and free radical scavenging activities of each peel extract were estimated in the form of Folin–Ciocalteu reagent assay, phosphomolybdenum assay, hydroxyl free radical scavenging assay, and superoxide free radical scavenging assay, respectively.

Results: The ethanolic peel extracts of P. granatum and C. sinensis showed significant increased total phenolic contents and total antioxidant activity. Furthermore, radical scavenging activity (hydroxyl and superoxide) was found to be significant in both ethanolic peel extracts.

Conclusion: It can be concluded from the study that the ethanolic peel extracts of P. granatum and C. sinensis has potential antioxidant and antiradical activity.
THE PROFILE OF THYROTROPIN-RELEASING HORMONE, T-REGULATOR, AND INTERLEUKIN-4 OF UNTREATED GRAVES’ DISEASE IN INDONESIA
Authors: DECROLI EVA , ELVIRA DWITYA , APRILIA DINDA
Published: July 2020

Objective: This study was conducted to the profile of hormonal and immunological aspects, which is thyrotropin-releasing hormone (TRH), T-regulator (T-reg) Forkhead box P3 (FOXP3) gene polymorphism, and interleukin-4 (IL-4) of untreated Graves’ disease with hyperthyroid in M Djamil General Hospital Padang, Indonesia.

Methods: A cross-sectional study was conducted to observe Graves’ disease with hyperthyroid in the Internal Medicine Department in Dr. M. Djamil Hospital, Padang, West Sumatera, Indonesia. Graves’ disease was confirmed by measuring free thyroxine (FT4), thyroid-stimulating hormone (TSH), and antithyroid peroxidase (anti-TPO). TRH, T-reg FOXP3 gene polymorphism, and IL-4 were examined with an enzyme-linked immunosorbent assay method.

Results: Twenty-five subjects with Graves’ disease included in this study with an average of age is 27.48 (5.6) years. Mean Wayne index is 23.44 (1.4), mean serum FT4 level is 55.55 (17.98) pmol/l, median serum TSH level is 0.041 (0.004–0.053) mU/l, and mean anti-TPO level is 2697.539 (479.72) pg/ml. Median serum TRH level is 92.589 (24.843–253.186) pg/ml, mean T-reg FOXP3 gene polymorphism is 0.621 (0.23) ng/ml, and mean serum IL-4 level is 19.759 (7.03) pg/ml).

Conclusion: Graves’ disease with hyperthyroid has median serum TRH level 92.589 (24.843-253.186) pg/ml and high levels of T-reg FOXP3 gene polymorphism and IL-4.
TOXICITY PROFILE OF CELASTRUS PANICULATUS SEEDS: A PRECLINICAL STUDY
Authors: MISHRA BHARAT , JOHN ELEZABETH , JOY KRUPAMOL , R BADMANABAN , R ALEESHA
Published: July 2020

Objective: The objective of the study was to evaluate the toxicity profile of Celastrus paniculatus (CP) by performing a preclinical study on Swiss albino mice and demonstrate a safety description through monitoring their autonomic, neurological, behavioral, physical, and biochemistry profiles.

Methods: The toxicity profiles (acute and subacute) of CP were evaluated using Swiss albino mice in which they were divided into four groups: Group I received 1% Tween 20 and dimethyl sulfoxide. Group II, III, and IV received CP seed oil orally, at doses of 300, 2000, and 5000 mg/kg body weight for both acute and subacute toxicity studies in accordance with Organization for Economic Cooperation and Development guidelines No. 423. Special attention was given during the first 4 h and daily thereafter for a total of 14 days. Behavioral profile, physical state changes, and other parameters such as tremors, convulsion, lethargy were noted. Clinical signs were observed daily during the 28 days of the treatment period. Body weights were measured once a week. On the 29th day, the animals were kept to overnight and blood samples were collected through retro-orbital puncture for biochemical analysis.

Results: In both acute and subacute toxicity studies, the treatment with CP did not affect the normal health status of animals. It is suggestive that CP is considered practically non-toxic.

Conclusion: The toxicity profile of CP seed oil was evaluated and found to be safe until 2000 mg/kg dose.
PERIARTICULAR REGIONAL ANALGESIA REDUCES PAIN AND HOSPITAL STAY AFTER TOTAL KNEE ARTHROPLASTY: A PROSPECTIVE, RANDOMIZED, AND DOUBLE-BLINDED CONTROLLED TRIAL
Authors: DAS PULIN BIHARI , SINGH ANAND KUMAR , CHATTERJEE ARINDAM , SINGH ANURAG
Published: July 2020

Objective: There are multiple post-operative pain protocols for patients who undergo total knee arthroplasty (TKA). Post-operative analgesia with opioids or epidural analgesia has its side effect. We compared the duration of hospital stay, pain score, and range of motion of a control group who had no local infiltration with a group who had local infiltration analgesia following TKA.

Methods: Randomization was done in 60 patients who underwent TKA in two groups, one who did not receive and the other who received a multimodal cocktail periarticular injection containing 30 ml of 0.5% bupivacaine, 1 ml of 30 mg ketorolac, 1 ml of 1 in 1000 adrenaline, 2 ml of 80 mg gentamycin, 5 ml of 750 mg cefuroxime, and rest 0.9% of normal saline. Visual analog score (VAS) for pain at rest was recorded and assessed preoperatively and postoperatively at 2, 6, 12, 24, 36 h, 2, 3, and 7 days and during an activity at 24 h, 36 h, 2, 3, and 7 days.

Results: The patient who had received the local injection used very few analgesics over the first 24 h of surgery. Moreover, patients, where local infiltration was used, showed lower VAS for pain (at rest and during activity). They also showed higher VAS for patients’ satisfaction.

Conclusion: Due to the reduced post-operative pain with periarticular injection analgesia, it was observed that the pain and duration of hospital stay were significantly reduced.
A COMPARISON OF CAUSALITY ASSESSMENT TOOLS FOR SUSPECTED ADVERSE DRUG REACTIONS IN HOSPITALIZED PATIENTS AT A TERTIARY CARE HOSPITAL
Authors: CD PARIKH , CK DESAI , JD KAPADIA , MK SHAH
Published: July 2020

Objective: The objective of the study was to compare six causality assessment (CA) tools for suspected adverse drug reactions (ADRs) reported in hospitalized patients at a tertiary care hospital in India.

Methods: Intensive ADR monitoring was performed in indoor patients of two randomly selected medicine units. A detailed case report of each suspected ADR (n=120) was provided to six independent experts for CA using either visual analog scale (VAS) or WHO-UMC scale. Investigator assessed causality using Naranjo’s scale, Koh et al. scale, the French method, and Karch and Lasagna scale. Similar causality categories from these scales were coded for correlation. Agreement among experts and that between various CA tools were analyzed using Cohen’s kappa and Fleiss kappa. Reasons for disagreements among different scales were evaluated.

Results: A variation was observed in the total number of drugs suspected to cause ADR by experts and investigator. “Likely” and “Plausible” causality were suggested frequently by experts using VAS whereas “Possible” causal association was frequent according to experts using the WHO-UMC scale and also by the investigator using algorithms except Koh et al. scale. None to the slight agreement was observed among experts who used VAS (k=0.117), whereas a substantial agreement was observed among experts using the WHO-UMC scale (k=0.707). A substantial agreement was observed between Karch and Lasagna scale and the French method (k=0.740). Both scales demonstrated moderate agreement with Naranjo’s scale. Disagreement among the WHO-UMC scale, the French method, and Karch and Lasagna scale were associated with polypharmacy, serious ADRs, non-availability of laboratory data, and skin and subcutaneous tissue ADRs.

Conclusion: A higher inter-rater agreement with the WHO-UMC scale suggests its utility for CA of suspected ADRs in indoor patients. The French method and Karch and Lasagna scale can be used for CA in hospitalized patients as an adjunct to Naranjo’s scale. Factors associated with disagreement should be considered at the time of reporting ADRs and evaluating causality.
THE USE OF SOCIAL MEDIA FOR PHARMACISTS’ PROFESSIONAL ACTIVITIES IN UNITED ARAB EMIRATES: A DESCRIPTIVE STUDY
Authors: IBRAHIM OSAMA MOHAMED , IBRAHIM RANA , AL-TAMEEMI NOOR KIFAH , RILEY KAREN
Published: July 2020

Objective: The aim of this study is to assess the perception of patients and pharmacists in the United Arab Emirates about social media uses in health-care delivery.

Methods: A cross-sectional survey was distributed among patients and pharmacists residing in Dubai, Sharjah and Abu Dhabi. Their perception of social media uses in delivering health-care services was evaluated by analyzing their attitude toward the benefits and associated risks of social media.

Results: The survey study had a total of 267 participants, including 150 patients and 117 pharmacists. Based on the results, 69.2% of the pharmacists agreed that social media, text message, or e-mail can be effectively used by them to improve patient communication. For patients, the study showed that the greatest percentage (77.3%, n=116) utilize both: Disease-related information and information on drugs. About 69.2% of pharmacists chose WhatsApp to be the most used platform, and 60.7% of patients prefer using Instagram as a health-care platform.

Conclusion: The use of professional development tools for social networking is likely to continue to evolve. Integrating social media with the practice of pharmacy and patient care will have a positive impact on achieving optimal patient care.
PHENOLIC COMPOUNDS FROM INDONESIAN WHITE TURMERIC (CURCUMA ZEDOARIA) RHIZOMES
Authors: DYAH UTAMI CAHYANING RAHAYU  , DWI AYU SETYANI  , HANHAN DIANHAR  , PURWANTININGSIH SUGITA
Published: July 2020

Objective: The aim of the present study is to isolate phenolic compounds from Curcuma zedoaria rhizomes grown in Bogor, West Java, Indonesia, which will enrich phytochemical information from this plant.

Methods: C. zedoaria rhizomes were macerated in methanol then followed by increasing polarity partitions with n-hexane, ethyl acetate (EtOAc), and methanol, respectively. EtOAc fraction was further fractionated using various chromatography techniques to yield two isolated fractions, Z1 and Z2. These two isolated fractions were then characterized to determine their compound structures.

Results: According to Fourier transform-infrared, ultraviolet-vis, and liquid chromatography–mass spectrometry (MS)/MS data, Z1 fraction was elucidated as curcuminoid derivative, that is, dimethoxycurcumin (DiMC, 1), while Z2 fraction was yielded as a mixture consisted of flavonoid and coumarin derivatives, that is, 3,5,7-trihydroxy-4’-methoxyflavon (kaempferide, 2) and 7-methoxy coumarin (herniarin, 3).

Conclusion: This study reveals useful information regarding phenolic constituents of Indonesian C. zedoaria rhizomes. Further research needs to be carried out to purify other compounds contained and to conduct bioactivity assays.
PENGARUH FORMULA SOSIS DENGAN PENAMBAHAN TEPUNG BIT (Beta vulgaris) PADA MUTU SOSIS DAGING BURUNG PUYUH AFKIR (Coturnix coturnix Japonica)
Authors: A. Nelis Oetavi , Khotimah Khusnul , Saati Elfi Anis
Published: July 2020

Sausage is a popular food product consumed by the world's population. Meat quail (Coturnix coturnix) is a meat product which has good prospects for use as a raw material for making sausages. The superiority of quail meat is a high protein content between 16,78% - 20,40% and about 70-74% yield of the weight of quail life. In order to increase consumer’s acceptability, the sausage needs a quality improvement especially in terms of appearance (color). One of the ingredients which have the potential as a natural dye is a beetroot (Beta vulgaris). The beetroot has a content of 200 mg of betanin/100 g. This study aims to determine the effect of different sausage formulas and the concentration of beetroot flour toward physicochemical and sensory properties of quail meat sausage. The research method used Randomized Block Design (RBD) with variation of beetroot flour concentration (0%, 1%, 2%, 3%, 4%, and 5% w/w of quail meat). Parameters analyzed were moisture content, protein content, fat content, ash content, antioxidant activity, texture, brightness, redness, yellowish, aroma, taste, and appearance. The best treatment is the quail meat sausage with the addition of the concentration of beet flour by 5% with water content 63,52%, protein content 13,44%, fat content 3,80%, ash 2,81%, antioxidant activity 47,95%, texture 5,19 N/mm2, lightness 44,33, redness 25,47, yellowish 13,20, aroma 3,4 of 5,00, taste 3,5 of 5,00, and appearance 4,04 of 5,00. All treatments have been in accordance with the standards based on SNI No. 01-3820-1995.
Karakteristik Fisik, Mekanik Dan Zona Hambat Edible Film Dari Pati singkong Karet (Manihot glaziovii) Dengan Penambahan Gliserol Dan Ekstrak Jahe Merah (Zingiber officinale Var Rubrum) Sebagai Penghambat Bakteri Salmonella
Authors: Amrillah Lady Agitasi , Warkoyo Warkoyo , Putri Desiana Nuriza
Published: July 2020

The edible film is one of the innovations used to overcome the food packaging problem. Components of edible films are hydrocolloids, lipids, and composites. Glycerol belongs to the hydrocolloid group which serves to maintain the solidity of the film sheet. The edible active film allegedly can inhibit physical, chemicals, and microbiology problems in the packaging which will affect the decline of food quality during storage. With the active compounds contained in red ginger it is expected to inhibit the growth of Salmonella bacteria. The purpose of this study was to determine the effect of the addition of different concentrations of glycerol and red ginger extract on the physical, mechanical, and inhibitory zones in the resulting edible film produced. This research used a nested design with 2 factors. The first factor was the addition of 20% glycerol concentration; 25%; 30% while the second factor is the addition of 0% red ginger extract; 0.5%; 1%; 1.5%. The treatments were 12 treatments with 3 replications. The parameters of this study include thickness, tensile strength, elasticity, WVTR, transparency, moisture content, solubility, density, and edible inhibition zone against Salmonella bacteria. The results showed that edible active red ginger film with the addition of glycerol had a significant effect on thickness, transparency, tensile strength and inhibition zone. On the addition of red ginger extract, 1.5% can inhibit the growth of Salmonella bacteria up to 34.17 mm.
Pemanfaatan Limbah Padat Sari Apel sebagai Bahan Baku Cuka Apel Menggunakan Metode Backslop
Authors: Novitasari Alvianty , Warkoyo Warkoyo , Winarsih Sri
Published: July 2020

Solid wasted of apple cider containing a lot of compounds such as carbohydrates, glucose, malic acid, and flavonoids. The purpose of this research is to utilize the solid wasted of apple cider as the raw material of apple vinegar. The fermentation process of making apple vinegar in this research using the backstop method. This research consists of 2 steps of the fermentation process. The first step of fermentation using yeast to transform sugar into alcohol. Second step fermentation is a continuance of first step fermentation with the addition of apple vinegar backstop culture which contain Acetobacter aceti with density 4 x 107cfu / ml to transform alcohol to acetic acid. This research uses simple and factorial Randomized Block Design (RBD). Fermentation phase I using simple RBD with the proportion of apple raw material (solid wasted of apple cider: apple) 100% : 0%; 75%: 25%; 50%: 50%; 25%: 75% as factor I. Fermentation phase II using factorial RBD with the combination of factor I and the addition of apple vinegar backstop with concentration 5%, 10%, and 15% as factor II. The results showed that during the first step fermentation process the raw material proportion of apple (solid wasted of apple cider: apple) affected total soluble solids, pH value, and alcohol content. Fermentation phase II showed an interaction between the proportion of the raw material of apple (apple cider waste: apple) and the addition of backstop apple vinegar concentration to total dissolved solids, alcohol content, acetic acid, except pH value. The best results showed treatment with apple material proportion (25% solid wasted of apple cider: 75% apple) and addition of apple vinegar backstop concentration 15 % produce 4.6 g / 100ml acetic acid, 4% soluble solids total, pH value of 3.4 and alcohol residue of 0% (v/v), with colorful organoleptic results quite appealing, the scent is sufficient, and preferences are favored by the panelists.
KARAKTERISTIK FISIK KIMIA KITOSAN DARI CANGKANG RAJUNGAN (Portunus pelagius) MELALUI PROSES DEASETILASI DENGAN KONSENTRASI NaOH DAN WAKTU EKSTRAKSI SERTA DI APLIKASIKAN SEBAGAI BAHAN PENGAWET ALAMI PADA FILLET IKAN NILA
Authors: Laili Izzah Nazilatul , Sukardi Sukardi , Harini Noor
Published: July 2020

This research is done by 2 stages of making chitosan and applying on tilapia fish fillet. Objectives at stage 1 to determine the optimization of the difference in NaOH concentration (20%, 30%, 40%, and 50%) and time (30 minutes and 45 minutes) deacetylation extraction. while the objective at stage 2 to find out the effect of the difference of chitosan addition to natural preservative of tilapia fillet (0,5,5%, 1%, 1,5%, and 2%). Chitosan tests were performed on physicochemical properties (moisture content, ash content, protein content, solubility, viscosity, yield, and deacetylation degree) and fish fillet test (organoleptic and total plate count (TPC). The results showed that different concentrations of NaOH and extraction time deacetylation very significant effect on ash content, protein content, viscosity, solubility, degree of deacetylation, and yield. While the concentration of chitosan is applied to meat Tilapia fish fillet very significant effect on the preservation of the storage period. The best treatment in stage 1 is K3A2.
Characteristics Characteristic Of Chemical Rice Analog Based On Arrowroot Starch (Maranta arundinacea) With The Addition Of Kelor Leaf (Moringa oleifera) and Broccoli Pulp
Authors: Damat Damat , Andini Ayu , Mujianto Mujianto
Published: July 2020

This research studied the effect of different sources and the percentage of chlorophyll on the quality of analog rice. This study uses Nested design with the first factor as the nest is the source of chlorophyll and second as a nested factor is the concentration of chlorophyll (5%, 7.5%, and 10%). The analysis tested was moisture content, ash, protein, lipid, fiber, carbohydrate, total calories, antioxidant activity, and total chlorophyll. After cooking, the rice conducted the sensory test (appearance, flavor, aroma, texture), antioxidant activity, and total chlorophyll. The results showed that the addition of chlorophyll sources and the percentage of chlorophyll affect moisture, ash, protein, fat, carbohydrate, fiber, total calories, antioxidant activity, total chlorophyll, and the appearance of analog rice as well as no effect on the flavor, texture, and aroma of analog rice. This research resulted that the lowest moisture of 8.22% derived from the treatment of 5% kelor leaf, the highest carbohydrate of 90.58% from the treatment of 5% broccoli pulp, the highest antioxidant activity in rice of 22.118% from treatment 10% broccoli pulp as well as the highest chlorophyll in rice of 10%, 2.72 mg/L from the treatment of kelor leaf.
Bienestar subjetivo: el papel de la rumia, optimismo, resiliencia y capacidad de recibir apoyo
Authors: Sánchez-Aragón Rozzana
Published: July 2020

El bienestar subjetivo comprende experiencias emocionales positivas/negativas, prosperidad y satisfacción con la vida. Además, depende de múltiples factores psicosociales como: la rumia, el optimismo, la resiliencia y la capacidad para recibir apoyo, mismos que han sido estudiados en particular y necesitan ser examinados en conjunto. Por ello, este estudio se propuso: 1) identificar el efecto de las variables mencionadas en el bienestar subjetivo en adultos, y 2) explorar sus diferencias a partir del sexo, edad y escolaridad. Se contó con la participación voluntaria de 404 adultos mexicanos de entre 18 y 64 años (M=37.56), con escolaridad mínima de secundaria. Los resultados muestran el papel significativo de algunos factores del optimismo, resiliencia y rumia en la predicción del bienestar subjetivo, así como diferencias en auto-confianza (optimismo), experiencia emocional negativa (bienestar subjetivo) y capacidad de recibir apoyo entre sexos, y la tendencia a experimentar más optimismo, resiliencia y bienestar conforme se tiene más edad y escolaridad. Estos resultados muestran como los atributos positivos y la experiencia de vida se asociacian con otras experiencias positivas en pro del bienestar del individuo.
Engaging migrant and refugee communities in non-formal science learning spaces
Authors: Brown Autumn , Roche Joseph , Hurley Mairéad
Published: July 2020

In this era of pandemics, economic crises and civil unrest, science centres and museums have an opportunity to become truly relevant resources to society. This paper summarises a number of critical lessons from the PISEA International Symposium, a conference held the at the Austrian Museum of Folk Life and Folk Art in Vienna from the 17th–18th of October 2019. The purpose of this event was to share, learn, and discuss ways in which engagement with migrants and refugee populations might be improved within informal science learning spaces. Issues around integration, inclusive art-science practice, and shifting institutional policy and language were all explored. This paper also calls for the committed reform of informal science spaces, and a renewed commitment to responsive, equitable, and inclusive practice.
Role and place of modern innovative medical technologies in treatment of viral pneumonia
Authors: Svistov A. S. , Onikienko S. B.
Published: July 2020

Purpose. To show the role of modern innovative medical technologies in the treatment of severe viral pneumonia caused by the COVID-19 virus.

Materials and methods. Clinical signs of coronavirus disease (COVID-19) were analyzed. Aspects of treatment of COVID-19 with the use of heated helium-oxygen mixture (HHOM) by applying Ingalit-V2-01 apparatus are shown.

Results and discussion. Successful use of Ingalit-V2-01 apparatus in 17 patients is shown.

Conclusion. Positive curative effect of modern high-technology innovative Ingalit-V2-01 apparatus, which provides a heated temperature up to 90–100° With a respiratory gas mixture of oxygen and helium together with an anticoagulant and surfactant in the early stages of coronavirus infection, it is associated not only with local (bronchopulmonary system), but also with systemic action on body.
Some aspects of studying the health risk of members of crews of marine vessels
Authors: Bogdanov A. A. , Voronov V. V. , Zagarov E. S.
Published: July 2020

Purpose: to study the acceptability of health risk factors of members of crews for shipbuilding purposes.

Materials and methods. The data on occupational pathology of seafarers over the period 2009–2018 were analyzed. The primary incidence of the adult population of nine coastal regions was studied. A survey was conducted on discomfort of working conditions, habitability factors of 174 crew members of vessels of 3 types.

Results and discussion. There is no records about occupational diseases of sailors over the past decade. The procedure for conducting a survey on the levels of discomfort of crew members is proposed.

Conclusion. In a simplified model of the vessel operation, it is possible to use the average discomfort values of the prototypes of crew members as preliminary indicators of the object’s effectiveness in terms of habitability.
Emergent synergistic biopsychosocial determinants of resiliency of subjects of extreme activity
Authors: Kotovskaya S. V. , Belenkova L. Y. , Boyko I. M.
Published: July 2020

Purpose. To establish the emergent-synergistic biopsychosocial determinants of the resiliency of subjects of extreme activity.

Materials and methods. To identify the determinants of resiliency 764 male subjects of various occupational groups, whose daily activities included an extreme component at a substantive level, were examined. All respondents were divided into 2 groups: a group of professionals with a high level of resiliency and a group of respondents with a low level of resiliency.

Results. Comparison of biopsychosocial features of subjects of extreme activity with the different level of resiliency showed that respondents with the high level of resiliency were focused on strategic life utilization, possessedsthenichyperthymic-demonstrative type of the personality, rational perception of reality, adequate level of aspiration, satisfaction with achievements path from the past to the present. Representatives of group with the low level of resiliencypreferred tactical use of psychophysiological resources, were characterized by sthenichyperthymic type of the personality with prevalence of domination in interpersonal communication, the irrational attitude towards reality, overestimated level of aspiration with orientation towards the future achievements.
To the question of improvement of the reporting medical documentation for a naval expedition
Authors: Zabrodskiy D. S. , Zaytsev A. G.
Published: July 2020

Purpose. To analyze results of questionnaire survey of naval medical service specialists on the question of processing of reporting documentation during the cruise.

Materials and methods. Questionnaire survey of chief medical officers, analysis of documents, Fisher angular transformation.

Results and discussion. Quantitative and qualitative analysis of questionnaires was conducted. The analysis showed that the reporting form shall be simplified and the chief medical officer should be given greater freedom in analyzing various aspects of the medical support of the cruise (the report should be less formalized).

Conclusion. Introduction of new reporting forms will allow to evaluate the efficiency of medical component during cruise and to give scientifically based recommendations to military equipment designers, ergonomists, and fleet command on issues of optimization of habitability specifications, implementation of new life-support technologies and lowering the accident rate on naval facilities.
Методология, методика, опыт работ по сохранению и приспособлению для современного использования парка Усадьбы Михалково. Часть 2
Authors: Belyaeva Elena , Markina Irina , Могинов Борис
Published: July 2020

На примере работ по сохранению объекта культурного на­следия (ОКН) регионального значения «Усадьба Михалково» в Москве рассмотрены методология и методика проектирова­ния парковой реставрации и задачи их совершенствования.

В 1784-1788 годах в Михалкове в стиле «псевдоготики» был построен архитектурный ансамбль парадного двора (архитектор В.И. Баженов) и устроен обширный пейзажный парк, куда вошли уже существовавшие в ту пору регулярный парк с копаными прудами и Головинские пруды.

Площадь ОКН «Усадьба Михалково» более 50 га. «Ядро усадьбы», включающее ансамбль парадного двора с регулярным парком - ОКН федерального значения, имеет площадь около 8 га.

Анализ архивных материалов и натурные обследования показали, что архитектурно-пространственная и ландшафтная организация изучаемого произведения СПИ соответствуют основным принципам создания русских пейзажных парков этого периода, особенно парков, характерных для творчества В.И. Баженова и его последователей.

На примере ОКН «Усадьба Михалково» показано, как про­счёты в оценке композиционных «особенностей» пейзажных парков, их сохранности, отсутствие в «предмете охраны» цен­ных элементов ландшафта могут негативно влиять на резуль­таты парковой реставрации. Для Михалково рекомендовано углублённое изучение композиционных особенностей пей­зажного парка, доработка «предмета охраны», исправление недостатков недавно выполненной парковой реставрации. Изучение опыта выполненных работ по реставрации и при­способлению к современному использованию имеет значение как для будущих реставраций рассматриваемого парка, так и для других исторических парков.
Создание биоцидных препаратов «Тефлекс» от синтеза нового полимера до линейки продукции. Часть 1. Разработка технологии получения био¬цидных препаратов «Тефлекс»
Authors: Erofeev Vladimir , Svetlov Dmitry , Smirnov Vasily , Краева Lyudmila , Lubchenkov Mikhail , Svetlov Daniil
Published: July 2020

В статье приводится обзор отечественной и зарубежной литературы по биоповреждениям в зданиях и сооружениях, методам биозащиты материалов и изделий и результатам ис­следований по технологии получения биоцидного препарата на основе соединений гуанидина. Показано, что повреждения строительных материалов, вызванные размножением на них бактерий и мицелиальных грибов, представляют серьёзную опасность как для конструкций зданий и сооружений, так и для здоровья людей. Одним из наиболее эффективных способов защиты строительных материалов и конструкций от поражений микроорганизмами является применение биоцид­ных соединений. К отвечающим современным требованиям нетоксичным биоцидным препаратам относятся полимеры и олигомеры природного или синтетического происхождения. Среди широкого спектра полимерных биоцидов выделяется группа соединений, содержащих в своём составе гуанидино­вую группировку (ПГМГ). Приводятся результаты исследова­ния авторов по технологии получения модифицированных препаратов ПГМГ. Выявлено увеличение биоцидного эф­фекта при их модификации добавками кислот. Установлена комплексообразующая способность макромолекул ПГМГ с хлоридом железа. Приведены результаты исследований по снижению токсичности ПГМГ посредством удаления аммиака при температурной обработке. В итоге получены биоцидные композиции с широким спектром свойств, пригодные для получения биоцидных композиционных строительных мате­риалов путём снижения обсеменённости микроорганизмами помещений, приборов, аппаратов, изделий, конструкций. Приведён перечень производимых по разрабатываемым технологиям биоцидных препаратов «Тефлекс».
Вопросы сохранения исторической среды города-курорта Светлогорск (Калининградская область)
Authors: Pustovgarov Victor
Published: July 2020

Актуальность данной статьи обусловлена тем, что истори­ческая среда в городах подвержена серьёзным изменениям ввиду возросшего интереса застройщиков к строительству в исторических зонах, использования исторического потен­циала территорий для продвижения различных проектов, направленных прежде всего на многоэтажное жилищное строительство. Состояние исторической застройки города- курорта федерального значения Светлогорска Калининград­ской области вызывает определённые вопросы, в том числе связанные с сохранением объектов культурного наследия. Историческая городская среда Светлогорска в целом пред­ставляет значительную культурную ценность, при этом ресурс исторического наследия города - значительный, разностиль­ный и многообразный - требует дальнейших исследований.

Основная часть архитектурных памятников, расположен­ных в городе, относится к выявленным объектам культурного наследия, но часть их реконструируется, разрушается, и на их месте или на прилегающих территориях из-за значитель­ного спроса на объекты недвижимости в курортном городе возводятся многоэтажные жилые дома. В последние три года были проведены определённые работы по подготовке документов на перевод выявленных объектов культурного наследия в объекты культурного наследия регионального, местного значения, но этот процесс опять затягивается, и при этом возникают всё новые грандиозные проекты по застройке ценных исторических территорий. Мы совершенно забыли, например, что существует и иной вид выражения величия и силы, кроме грандиозного. Мастера прошлого это знали и создавали произведения подлинного искусства, говорящие языком истинного величия покоя и простоты... [1].
О пространственной типологии зданий-арок
Authors: Gelfond Anna
Published: July 2020

В статье рассматривается пространственная типология зданий-арок. Анализ ведётся с нескольких позиций:

градостроительной: здание-арка рассматривается как элемент крупного общественного пространства;

композиционной: приём вычитания - проём вырезан в цельном объёме на полную или неполную высоту; приём сло­жения - самостоятельные башенные объёмы соединены между собой третьим объёмом - мостом-переходом; сочетание приёмов;

типологической: исследуются здания офисно-деловых и торговых центров, вокзальных комплексов, технопарков, жилые дома, многофункциональные сооружения;

функционально-планировочной: анализируется функциональное наполнение составляющих архитектурной формы, организация внешних и внутренних коммуникаций;

психологической и знаково-символической: форма арки как единство в противостоянии, символ успеха и приглашения к сотрудничеству;

здания-арки классифицируются в зависимости от их типо­логического потенциала на следующие варианты: калитка-ворота, окно; рама-портал; пассаж; арки с заполнением; переходный тип.

Вводится понятие «типологический (или пространствен­ный) потенциал» архитектурного объекта, который скла­дывается на основе функционального, конструктивного и композиционно-художественного потенциала.

В основе всех авторских посылов лежат результаты анализа архитектуры зданий-арок на примере зарубежного и отече­ственного опыта последних десятилетий. При этом описываются здания-арки различных типов, как с проёмами различной формы, так и с заполнением, имитирующим их путём уменьшения ви­зуальной массы центральной части. Автор статьи подчёркивает, что, фиксируя переходное состояние между внешним и внутрен­ним пространством, такие объекты выступают в двух главных ипостасях: как самостоятельное многофункциональное здание и как элемент архитектурной среды города.

Выявляя тенденции развития архитектурной формы но­вейших зданий-арок, автор указывает на то, что актуальным является переход от лаконичной формы к сложным простран­ственным структурам, проекция планов и генпланов на фасад, новая трактовка арочных пространств дворов.

Статья иллюстрирована фотографиями, подавляющее большинство из которых сделано автором статьи.
Будущее после Победы
Authors: Kosenkova, Julia
Published: July 2020

В последние годы Великой Отечественной войны и период послевоенного восстановления на фоне огромного подъёма патриотических настроений государством и обществом были предприняты усилия для того, чтобы воссоздать разрушенные города на новой основе, искоренив все недостатки в их планировке и застройке, сделать их лучше, красивее, удобнее для жизни. В статье кратко рассказывается о том, каким виделся город ближайшего будущего в первые годы разработки про-ектов восстановления городов, разрушенных войной.
Молодые национальные школы ХХ века - социокультурные и профессиональные парадигмы формирования архитектуры столиц. Зарубежная практика
Authors: Malinovskaya Elizaveta
Published: July 2020

Современный этап развития мировой культуры отмечен про­цессом интенсивного формирования молодых национальных школ. Особый интерес вызывают те, что пришли к професси­ональному творчеству в ХХ веке на основе взаимоадаптации культур различного типа: Запад - Восток, профессиональное - народное, современное - фольклорное. Не простая констата­ция архитектурной хроники, но определение закономерностей такого рода взаимовлияний с учётом параметров конкретной этнокультурной ситуации, имеет первостепенное значение. Подобная творческая парадигма пока не была предметом ис­следования. В процессе становления современных националь­ных школ данная концепция приобретает особую весомость в процессе изучения специфики строительства новых столиц зарубежных государств или же реконструкции имеющихся, как это было в Центральной Азии[1]. Анализ практики позволил обо­значить возможные варианты творческих моделей: приоритет профессиональных или историко-культурных систем координат, в идеале - их баланс. Примеры данных явлений определили выбор материала статьи. Он характеризует основные факторы сложения столиц Австралии, Индии, Бразилии и республик Со­ветского Востока[2], выявляя их миссию в динамике самоопреде­ления архитектуры этих стран. Обозначены основные аспекты проектирования в синтезе с наследием или футуристическом диссонансе с ним выдающихся зодчих Ле Корбюзье, О. Нимей- ера, архитектурных концепций А.С. Косинского для Ташкента. Дан обзор проектов европейского и русского авангарда начала ХХ века, трансформировавших центральноазиатские традиции как оседлой, так и кочевой архитектуры. Исследованы примеры, отражающие специфику работы инонациональных архитекто- ров-профессионалов в историко-культурной среде региона, их роли в становлении национальной идентичности школ. Обозна­чен вклад зарубежных и советских зодчих в мировое наследие модернизма в контексте поставленных автором задач[3].

 

[1]  Материал статьи связан с архитектурой модернизма. В данном номере представлен анализ по архитектуре зарубежных стран. Продолжение статьи будет посвящено специфике сложения Центральноазиатских столиц.

[2] Советский Восток - это республики Кавказа и Туркестана, переименованного в Среднюю Азию. С развалом СССР вновь используется историческое название региона - Центральная Азия. Термин «Советский Восток», тем не менее, употребляется, подразумевая советские республики.

[3] Отдельные положения статьи использовались в докладе на III Международной научно-практической конференции «Культурный текст Астаны» (к 20-летию столицы, 2018).
Загадка Леблона
Authors: Mazaev Grigory
Published: July 2020

В статье рассматривается первый регулярный план новой столицы России - Санкт-Петербурга, разработанный в 1717 году французским архитектором Ж.-Б. Леблоном. Проведено срав­нение мнений исследователей об этом проекте. Показаны прямо противоположные оценки плана Леблона - от восторженных до обвинений автора в неумении учесть очевидные местные условия строительства. Такой разброс мнений дал основу для проведения анализа проекта. Проведён топологический анализ плана города на основе сформулированных понятий «город на реке» и «город у реки». Показано, что размещение города на речном рассечении - частый приём в российском градострои­тельстве, речное рассечение снижает сплошность планировки в среднем на 22%. Сплошность плана Петербурга всего на 3% ниже средней. Это опровергает традиционное обвинение Леблона в неучёте условий строительства на реке - его проект вполне со­ответствует топологическому классу «города на реке».

Показано, что Леблон проектировал город-крепость по типу бастионной системы Вобана в соответствии с выбором Петра I. Мнение о том, что города-крепости - это «пройден­ный этап», опровергается их строительством в России до конца XIX века. Леблон показал прекрасное знание фортифи­кации, используя передовые решения оборонного зодчества.

Анализ градостроительной композиции, разработанной Леблоном, его планировочных и композиционных решений, про­ведённый по авторской методике, построенной на выявлении городских пространств, образующих целостную систему центра, показал её разнообразие, большие возможности в создании парадных столичных архитектурных ансамблей, открытых набе­режных. Проект Леблона построен на связи города с природой. Наиболее часто отмечаемый «недостаток» проекта Леблона - ограничение возможного роста города, но он видится с пози­ций знания 300-летней истории города. «Идеальные» проекты городов не предусматривали их роста, а предполагали развитие системы расселения. Леблон разработал проект в традиции своего времени, предложенный им «идеальный» город рассматривался исключительно как центр высшей власти и не должен был расти.

Проведены сравнения планировочных решений проектов Леблона и Трезини, показаны их принципиальные расхождения по базовым принципам разработки двух планов Петербурга.

В статье сделан вывод, что проект Леблона есть образец градостроительства как искусства, создающий новый образ столицы России. Отказ от его реализации определён возоб­ладанием утилитарного отношения к градостроительству как к «нарезке кварталов» - это «победа здравого смысла» над искусством, которая лишила Россию выдающегося произ­ведения градостроительства.