bluuebunny/crossref_metadata_2025 huggingface dataset:
The Elements of Medical Chemistry
Authors: Paris John Ayrton
Published: November 2014

The physician and author John Ayrton Paris (1785–1856), several of whose other medical and popular works have been reissued in the Cambridge Library Collection, published the first edition of his Pharmacologia in 1812. It was immediately successful, and went into eight further editions until 1843. The third edition, of 1820, has been reissued in this series. This book, published in 1825, was intended as a companion volume, providing a 'grammar' of chemistry for the medical student. After an imaginary dialogue on the importance of chemistry, between a provincial physician and 'the author', to whom the former is entrusting his son for his medical education, the book moves systematically from the general application of chemistry to medicine, through topics such as gravity, crystallization and electricity, to the detail of the actions of specific elements, and tables of relevant weights and measures, providing fascinating insights into the history of medical education.
Life amongst the Indians
Authors: Catlin George
Published: November 2014

The American artist George Catlin (1796–1872) was fascinated by the indigenous peoples of North and South America. Spending many years travelling and living among different tribes, he felt compelled by a desire to rescue from destruction 'the looks and customs of the vanishing races of native man in America'. Famed for his paintings of Native Americans, he also wrote a number of books. In the present work, first published in 1861, Catlin recounts his childhood in Pennsylvania, where he witnessed hostilities between settlers and the indigenous people. He also covers his later travels through the Americas and his time in Europe, where he introduced visiting Native Americans to English and French royalty. Although intended for children, his illustrated stories make lively and compelling reading for all ages. Catlin's 1868 follow-up, Last Rambles Amongst the Indians of the Rocky Mountains and the Andes, is also reissued in this series.
The Life of Robert Stephenson, F.R.S.
Authors: Jeaffreson John Cordy , Pole William
Published: November 2014

Relying on incremental experiment and practice rather than individual leaps into the unknown, Robert Stephenson (1803–59) forged an influential career as a highly respected railway and civil engineer. From the steam locomotive Rocket to the London and Birmingham Railway and the Britannia Bridge, his work helped to consolidate the foundations of the modern engineering profession. Based on the first-hand testimony of relatives and contemporaries as well as correspondence and official records, this 1864 biography by John Cordy Jeaffreson (1831–1901), published only five years after Stephenson's death, tells the story of this quiet industrial innovator. Five chapters by engineer William Pole (1814–1900) provide a more technical insight, examining some of Stephenson's most significant railway bridges. Volume 2 covers his advocacy of standardisation of the permanent way during the Gauge War, and his life as a bridge builder and politician.
Northern Waters
Authors: Nansen Fridtjof
Published: November 2014

In later life the recipient of the Nobel Peace Prize for his humanitarian work, the explorer and scientist Fridtjof Nansen (1861–1930) encouraged and supported the 1901 voyage of his fellow Norwegian Roald Amundsen (1872–1928), publishing this account of its scientific findings in 1906. Amundsen had just purchased his famous boat, the Gjøa, and wanted to test her in Arctic waters. He planned to pay for the expedition by hunting seals, but wanted to carry out scientific work at the same time. On Nansen's advice, he decided to make oceanographic observations. After a six-month voyage, he returned with both observations and samples of water and plankton which considerably enlarged understanding of the bottom waters of the Norwegian Sea and the play of current in the area. Nansen's work supplies technical details, diagrams and maps from this remarkable scientific survey.
History of the Manchester Ship Canal from its Inception to its Completion
Authors: Leech Bosdin
Published: November 2014

By the late nineteenth century, charges imposed on Manchester companies for the use of Liverpool's docks and the connecting railway had created an atmosphere of resentment within the business community. The Manchester Ship Canal was to play a major part in the city's regeneration following the depression of the 1870s, but it took a lengthy battle for the scheme to gain the backing of Parliament and for construction to begin in 1887. In this two-volume work of 1907, Sir Bosdin Leech (1836–1912) traces the canal's conception, planning and construction. Volume 2 begins with the project's backers having finally raised the capital necessary to begin construction. The difficult process of building the canal is then detailed. The work includes a large amount of illustrative content, enhancing the light shed on the landscape and notable personalities of Manchester at that time.
The Principal Navigations Voyages Traffiques and Discoveries of the English Nation
Authors: Hakluyt Richard
Published: November 2014

Richard Hakluyt (1552?–1616) was fascinated from his earliest years by stories of strange lands and voyages of exploration. A priest by profession, he was also an indefatigable editor and translator of geographical accounts, and a propagandist for English expeditions to claim new lands, especially in the Americas. His most famous work was first published in 1589, and expanded in 1598–1600: reissued here is the twelve-volume edition prepared by the Scottish firm of James MacLehose and Sons and first published between 1903 and 1905, which included introductory essays and notes. Hakluyt's subjects range from transcriptions of personal accounts and 'ruttiers' (descriptive charts of voyages) to patriotic attacks against rival nations (especially Spain). Volume 4 includes accounts ranging from the legendary journey of St Helena, the mother of Constantine, from Britain to Jerusalem, to medieval pilgrimages to the Holy Land, to the defeat of the Spanish Armada in 1588.
In Northern Mists
Authors: Nansen Fridtjof
Published: November 2014

Accounts of the earliest exploration of the Arctic are scattered through many literatures. In writing this work, reissued here in the two-volume English translation of 1911, the celebrated Norwegian explorer Fridtjof Nansen (1861–1930) returned to many of the original sources. Calling on others to help him interpret texts in several languages, Nansen begins his account with the first mentions of the Arctic in Greek literature and ends with voyages of the sixteenth century. He notably questions some of the traditional history based on Norse sagas. Each volume contains lengthy quotations from little-known documents, making much valuable information accessible to non-specialists. Volume 2 continues from the discovery of North America through the explorations of the Inuit to the decline of the settlements in Greenland. Nansen describes early Norwegian explorations, considers the maps available to early explorers, and closes with the discoveries made by Cabot and the Portuguese.
Stray Leaves from an Arctic Journal
Authors: Osborn Sherard
Published: November 2014

By the middle of the nineteenth century, the goal of the North-West Passage had claimed the lives of many explorers, yet the disappearance of the expedition led by Sir John Franklin occasioned the greatest response. Naval officer Sherard Osborn (1822–75) took part in the search mission of 1850–1 under Horatio Thomas Austin. Osborn was appointed to command the Pioneer, one of two steam tenders on the voyage. This was the first time such vessels had been deployed in the punishing conditions of the Arctic. Such was their success in cutting through ice and navigating the treacherous waters that similar models were later adopted by the whaling fleet. The present work, first published in 1852, gives a compelling account of the hardships of the expedition, which was successful in its surveying work and confirmed that Franklin had not been lost in Baffin Bay.
A Glossary of Terms Used in Grecian, Roman, Italian, and Gothic Architecture
Authors: Parker John Henry
Published: November 2014

The Oxford bookseller and publisher John Henry Parker (1806–84), a supporter of the Tractarian movement and a friend of Cardinal Newman, was also a historian of architecture, and first published this glossary in 1836. Reissued here is the enlarged third edition of 1840. The work is ordered alphabetically, and illustrated with 700 woodcuts by various artists. As stated in the first edition's preface, the book 'lays no claim to originality, its sole object being utility'. By 1837, 'the rapid sale of the first edition of this work clearly shews that something of the kind was required'. The third edition was followed in 1841 by a companion volume: the two books offered a useful guide for those travellers and others who were taking a keen interest in the built environment. The companion volume contains further line drawings and plates, an index to the plates in both volumes, and a chronology of the architectural developments and individual buildings being discussed.
Arctic Zoology
Authors: Pennant Thomas
Published: November 2014

In the 'Advertisement' to this 1784 two-volume work, Thomas Pennant (1726–98), zoologist and traveller, explains that his original intention was to record the zoology of North America 'when the empire of Great Britain was entire'. After the War of Independence, he changed his focus to the zoology (and people, archaeology and geology) of the Arctic regions of America, Europe and Siberia. The content of the volumes, one of the earliest works of systematic zoology published in Britain, is based on the writings of earlier zoologists, information obtained by Pennant from his scientific correspondents all over Europe and America, and his studies in private museums and collections. It is embellished with engravings of animals, birds, landscapes and artefacts. Volume 1 begins with an account of the various Arctic habitats, and describes the quadrupeds of these regions. Other works by Thomas Pennant are also reissued in the Cambridge Library Collection.
International Courts and the Performance of International Agreements
Authors: Carrubba Clifford J. , Gabel Matthew J.
Published: November 2014

Nations often turn to international courts to help with overcoming collective-action problems associated with international relations. However, these courts generally cannot enforce their rulings, which begs the question: how effective are international courts? This book proposes a general theory of international courts that assumes a court has no direct power over national governments. Member states are free to ignore both the international agreement and the rulings by the court created to enforce that agreement. The theory demonstrates that such a court can, in fact, facilitate cooperation with international law, but only within important political constraints. The authors examine the theoretical argument in the context of the European Union. Using an original data set of rulings by the European Court of Justice, they find that the disposition of court rulings and government compliance with those rulings comport with the theory's predictions.
The Managerial Sources of Corporate Social Responsibility
Authors: Thauer Christian R.
Published: November 2014

Why and under which conditions do companies voluntarily adopt high social and environmental standards? Christian Thauer looks inside the firm to illustrate the internal drivers of the social conduct of business. He argues that corporate social responsibility (CSR) assists decision-makers to resolve managerial dilemmas. Drawing on transaction cost economics, he asks why and which dilemmas bring CSR to the fore. In this context he describes a managerial dilemma as a situation where the execution of management's decisions transforms the mode of cooperation within the organization from a hierarchy to one in which managers become dependent on, and vulnerable to, the behavior of subordinates. Thauer provides empirical illustration of his theory by examining automotive and textile factories in South Africa and China. Thauer demonstrates that CSR is often driven by internal management problems rather than by the external pressures that corporations confront.
Interpreting Crimes in the Rome Statute of the International Criminal Court
Authors: Grover Leena
Published: November 2014

The Rome Statute of the International Criminal Court defines more than ninety crimes that fall within the Court's jurisdiction: genocide, other crimes against humanity, war crimes and aggression. How these crimes are interpreted contributes to findings of individual criminal liability, and moreover affects the perceived legitimacy of the Court. And yet, to date, there is no agreed-upon approach to interpreting these definitions. This book offers practitioners and scholars a guiding principle, arguments and aids necessary for the interpretation of international crimes. Leena Grover surveys the jurisprudence of the International Criminal Tribunals for the former Yugoslavia and Rwanda before presenting a model of interpretive reasoning that integrates the guidance within the Rome Statute into articles 31-33 of the Vienna Convention on the Law of Treaties (1969).
A Narrative of Lord Byron's Last Journey to Greece
Authors: Gamba Pietro
Published: November 2014

Count Pietro Gamba (1801–27) was the brother of Teresa Guiccioli, Lord Byron's mistress, and a member of the Italian revolutionaries known as the Carbonari. He accompanied Byron on his mission to Greece in 1823, and was described by the poet as 'one of the most amiable, brave, and excellent young men' he had ever encountered, 'with a thirst for knowledge, and a disinterestedness rarely to be met with'. This account of the mission, and of Byron's death and the subsequent controversies over its cause and the disposal of the body, was published in 1825, and dedicated to Byron's close friend, John Cam Hobhouse. It was based on Gamba's diary, 'containing a minute account of all the events of the day … My only object is to give a simple narrative of what Lord Byron did in Greece'. Gamba died of typhoid in 1827, still working for Greek independence.
Ocean of Trade
Authors: Machado Pedro
Published: November 2014

Ocean of Trade offers an innovative study of trade, production and consumption across the Indian Ocean between the years 1750 and 1850. Focusing on the Vāniyā merchants of Diu and Daman, Pedro Machado explores the region's entangled histories of exchange, including the African demand for large-scale textile production among weavers in Gujarat, the distribution of ivory to consumers in Western India, and the African slave trade in the Mozambique channel that took captives to the French islands of the Mascarenes, Brazil and the Rio de la Plata, and the Arabian peninsula and India. In highlighting the critical role of particular South Asian merchant networks, the book reveals how local African and Indian consumption was central to the development of commerce across the Indian Ocean, giving rise to a wealth of regional and global exchange in a period commonly perceived to be increasingly dominated by European company and private capital.
The Orient and the Young Romantics
Authors: Warren Andrew
Published: November 2014

Through close readings of major poems, this book examines why the second-generation Romantic poets - Byron, Shelley, and Keats - stage so much of their poetry in Eastern or Orientalized settings. It argues that they do so not only to interrogate their own imaginations, but also as a way of criticizing Europe's growing imperialism. For them the Orient is a projection of Europe's own fears and desires. It is therefore a charged setting in which to explore and contest the limits of the age's aesthetics, politics and culture. Being nearly always self-conscious and ironic, the poets' treatment of the Orient becomes itself a twinned criticism of 'Romantic' egotism and the Orientalism practised by earlier generations. The book goes further to claim that poems like Shelley's Revolt of Islam, Byron's 'Eastern' Tales, or even Keats's Lamia anticipate key issues at stake in postcolonial studies more generally.
The Material Life of Roman Slaves
Authors: Joshel Sandra R. , Hackworth Petersen Lauren
Published: November 2014

The Material Lives of Roman Slaves is a major contribution to scholarly debates on the archaeology of Roman slavery. Rather than regarding slaves as irretrievable in archaeological remains, the book takes the archaeological record as a key form of evidence for reconstructing slaves' lives and experiences. Interweaving literature, law, and material evidence, the book searches for ways to see slaves in the various contexts - to make them visible where evidence tells us they were in fact present. Part of this project involves understanding how slaves seem irretrievable in the archaeological record and how they are often actively, if unwittingly, left out of guidebooks and scholarly literature. Individual chapters explore the dichotomy between visibility and invisibility and between appearance and disappearance in four physical and social locations - urban houses, city streets and neighborhoods, workshops, and villas.
The Sainte-Chapelle and the Construction of Sacral Monarchy
Authors: Cohen Meredith
Published: November 2014

This book offers a novel perspective on one of the most important monuments of French Gothic architecture, the Sainte-Chapelle, constructed in Paris by King Louis IX of France between 1239 and 1248 especially to hold and to celebrate Christ's Crown of Thorns. Meredith Cohen argues that the chapel's architecture, decoration, and use conveyed the notion of sacral kingship to its audience in Paris and in greater Europe, thereby implicitly elevating the French king to the level of suzerain, and establishing an early visual precedent for the political theories of royal sovereignty and French absolutism. By setting the chapel within its broader urban and royal contexts, this book offers new insight into royal representation and the rise of Paris as a political and cultural capital in the thirteenth century.
Type Theory and Formal Proof
Authors: Nederpelt Rob , Geuvers Herman
Published: November 2014

Type theory is a fast-evolving field at the crossroads of logic, computer science and mathematics. This gentle step-by-step introduction is ideal for graduate students and researchers who need to understand the ins and outs of the mathematical machinery, the role of logical rules therein, the essential contribution of definitions and the decisive nature of well-structured proofs. The authors begin with untyped lambda calculus and proceed to several fundamental type systems, including the well-known and powerful Calculus of Constructions. The book also covers the essence of proof checking and proof development, and the use of dependent type theory to formalise mathematics. The only prerequisite is a basic knowledge of undergraduate mathematics. Carefully chosen examples illustrate the theory throughout. Each chapter ends with a summary of the content, some historical context, suggestions for further reading and a selection of exercises to help readers familiarise themselves with the material.
A History of the Criminal Law of England
Authors: Stephen James Fitzjames
Published: November 2014

Sir James Fitzjames Stephen (1829–94) published this three-volume account of the English criminal law's historical development in 1883, four years after his appointment as a judge of the High Court. It is a revision and expansion of the second chapter in Stephen's 1863 General View (also reissued in this series). At first sight, it is ironic that the author of this classic of legal historical scholarship was himself a Benthamite who favoured and promoted the codification of the common law and worked on codes of criminal law and procedure for India and for England. Volume 3 covers the history of the criminal offences not covered in Volume 2 (murder and other offences against the person; theft and other property offences; and offences relating to trade and labour) and also covers the development of Indian criminal law and the main features of the Indian Penal Code of 1860 and Code of Criminal Procedure of 1882.
A General View of the Criminal Law of England
Authors: Stephen James Fitzjames
Published: November 2014

The jurist Sir James Fitzjames Stephen (1829–94) published this work in 1863 to provide the intelligent layman with a general account of the workings and principles of English criminal law. He begins with a brief sketch of the development of that law from the Anglo-Saxon period onwards. He then covers the current law on criminal responsibility and the classification and definition of specific crimes, before turning to procedure and the rules of evidence. The book helped to establish Stephen's reputation and made possible his appointment as legal member of the Indian viceroy's council in succession to Henry Maine in 1869. Work on its revision for a second edition led Stephen into producing separate and authoritative digests of the law of evidence, criminal law, and criminal procedure, as well as his three-volume History of the Criminal Law of England, published in 1883 and also reissued in this series.
The Creation of the Zulu Kingdom, 1815–1828
Authors: Eldredge Elizabeth A.
Published: November 2014

This scholarly account traces the emergence of the Zulu Kingdom in South Africa in the early nineteenth century, under the rule of the ambitious and iconic King Shaka. In contrast to recent literary analyses of myths of Shaka, this book uses the richness of Zulu oral traditions and a comprehensive body of written sources to provide a compelling narrative and analysis of the events and people of the era of Shaka's rule. The oral traditions portray Shaka as rewarding courage and loyalty and punishing failure; as ordering the targeted killing of his own subjects, both warriors and civilians, to ensure compliance to his rule; and as arrogant and shrewd, but kind to the poor and the mentally disabled. The rich and diverse oral traditions, transmitted from generation to generation, reveal the important roles and fates of men and women, royal and subject, from the perspectives of those who experienced Shaka's rule and the dramatic emergence of the Zulu Kingdom.
Reading Fiction with Lucian
Authors: ní Mheallaigh Karen
Published: November 2014

This book offers a captivating new interpretation of Lucian as a fictional theorist and writer to stand alongside the novelists of the day, bringing to bear on his works a whole new set of reading strategies. It argues that the aesthetic and cultural issues Lucian faced, in a world of mimesis and replication, were akin to those found in postmodern contexts: the ubiquity of the fake, the erasure of origins, the focus on the freakish and weird at the expense of the traditional. In addition to exploring the texture of Lucian's own writing, Dr ní Mheallaigh uses Lucian as a focal point through which to examine other fictional texts of the period, including Antonius Diogenes' The Incredible Things Beyond Thule, Dictys' Journal of the Trojan War and Ptolemy Chennus' Novel History, and reveals the importance of fiction's engagement with its contemporary culture of writing, entertainment and wonder.
Slavery and the Politics of Place
Authors: Bohls Elizabeth A.
Published: November 2014

Geography played a key role in Britain's long national debate over slavery. Writers on both sides of the question represented the sites of slavery - Africa, the Caribbean, and the British Isles - as fully imagined places and the basis for a pro- or anti-slavery political agenda. With the help of twenty-first-century theories of space and place, Elizabeth A. Bohls examines the writings of planters, slaves, soldiers, sailors, and travellers whose diverse geographical and social locations inflect their representations of slavery. She shows how these writers use discourses of aesthetics, natural history, cultural geography, and gendered domesticity to engage with the slavery debate. Six interlinked case studies, including Scottish mercenary John Stedman and domestic slave Mary Prince, examine the power of these discourses to represent the places of slavery, setting slaves' narratives in dialogue with pro-slavery texts, and highlighting in the latter previously unnoticed traces of the enslaved.
Modernism and Naturalism in British and Irish Fiction, 1880–1930
Authors: Joyce Simon
Published: November 2014

This book argues that the history of literary modernism is inextricably connected with naturalism. Simon Joyce traces a complex response among aesthetes to the work of Émile Zola at the turn of the century, recovering naturalism's assumed compatibility with impressionism as a central cause of their ambivalence. Highlighting a little-studied strain of reflexive naturalism in which Zola's mode of analytical observation is turned upon the authors themselves, Joyce suggests that the confluence of naturalism and impressionism formed the precondition for so-called stream-of-consciousness writing. This style served to influence not only the work of canonical modernists such as Joyce and Woolf, but also that of lesser-known writers such as George Moore, Sarah Grand, and George Egerton.
Thinking Functionally with Haskell
Authors: Bird Richard
Published: November 2014

Richard Bird is famed for the clarity and rigour of his writing. His new textbook, which introduces functional programming to students, emphasises fundamental techniques for reasoning mathematically about functional programs. By studying the underlying equational laws, the book enables students to apply calculational reasoning to their programs, both to understand their properties and to make them more efficient. The book has been designed to fit a first- or second-year undergraduate course and is a thorough overhaul and replacement of his earlier textbooks. It features case studies in Sudoku and pretty-printing, and over 100 carefully selected exercises with solutions. This engaging text will be welcomed by students and teachers alike.
Community Stroke Rehabilitation Teams: Providing Home-Based Stroke Rehabilitation in Ontario, Canada
Authors: Allen L. , Richardson M. , McIntyre A. , Janzen S. , Meyer M. , Ure D. , Willems D. , Teasell R.
Published: November 2014

Background: Community stroke rehabilitation teams (CSRTs) provide a community-based, interdisciplinary approach to stroke rehabilitation. Our objective was to assess the effectiveness of these teams with respect to client outcomes. Methods: Functional, psychosocial, and caregiver outcome data. were available at intake, discharge from the program, and six-month follow-up. Repeated measures analysis of covariance was performed to assess patient changes between time points for each outcome measure. Results: A total of 794 clients met the inclusion criteria for analysis (54.4% male, mean age 68.5±13.0 years). Significant changes were found between intake and discharge on the Hospital Anxiety and Depression Scale total score (p=0.017), Hospital Anxiety and Depression Scale Anxiety subscale (p<0.001), Functional Independence Measure (p<0.001), Reintegration to Normal Living Index (p=0.01), Bakas Caregiver Outcomes Scale (p<0.001), and Caregiver Assistance and Confidence Scale assistance subscale (p=0.005). Significant gains were observed on the strength, communication, activities of daily living, social participation, memory, and physical domains of the Stroke Impact Scale (all p<0.001). These improvements were maintained at the 6-month follow-up. No significant improvements were observed upon discharge on the memory and thinking domain of the Stroke Impact Scale; however, there was a significant improvement between admission and follow-up (p=0.002). All significant improvements were maintained at the 6-month follow-up. Conclusions: Results indicate that the community stroke rehabilitation teams were effective at improving the functional and psychosocial recovery of patients after stroke. Importantly, these gains were maintained at 6 months postdischarge from the program. A home-based, stroke-specific multidisciplinary rehabilitation program should be considered when accessibility to outpatient services is limited.
Biotransformation of anthelmintics and the activity of drug-metabolizing enzymes in the tapeworm Moniezia expansa
Authors: PRCHAL LUKÁŠ , BÁRTÍKOVÁ HANA , BEČANOVÁ ANETA , JIRÁSKO ROBERT , VOKŘÁL IVAN , STUCHLÍKOVÁ LUCIE , SKÁLOVÁ LENKA , KUBÍČEK VLADIMÍR , LAMKA JIŘÍ , TREJTNAR FRANTIŠEK , SZOTÁKOVÁ BARBORA
Published: November 2014

The sheep tapeworm Moniezia expansa is very common parasite, which affects ruminants such as sheep, goats as well as other species. The benzimidazole anthelmintics albendazole (ABZ), flubendazole (FLU) and mebendazole (MBZ) are often used to treat the infection. The drug-metabolizing enzymes of helminths may alter the potency of anthelmintic treatment. The aim of our study was to assess the activity of the main drug-metabolizing enzymes and evaluate the metabolism of selected anthelmintics (ABZ, MBZ and FLU) in M. expansa. Activities of biotransformation enzymes were determined in subcellular fractions. Metabolites of the anthelmintics were detected and identified using high performance liquid chromatography/ultra-violet/VIS/fluorescence or ultra-high performance liquid chromatography/mass spectrometry. Reduction of MBZ, FLU and oxidation of ABZ were proved as well as activities of various metabolizing enzymes. Despite the fact that the conjugation enzymes glutathione S-transferase, UDP-glucuronosyl transferase and UDP-glucosyl transferase were active in vitro, no conjugated metabolites of anthelmintics were identified either ex vivo or in vitro. The obtained results indicate that sheep tapeworm is able to deactivate the administered anthelmintics, and thus protects itself against their action.
The Arab Spring and the Question of Legality of Democratic Revolution in Theory and Practice: A Perspective Based on the African Union Normative Framework
Authors: OBSE KALKIDAN
Published: November 2014

Traditional rules of international law do not recognize a positive right of revolution, nor a prohibition thereof as the relevant rules merely place the legality of revolutions in their effectiveness. However, the recent upsurge in democratically inspired revolutions has provided high currency to proposals that seek to re-evaluate the position of international law towards revolutions. Proponents of the theory of democratic revolution have sought to establish the legality of revolutions on an elevated normative ground using the lofty ideals of human rights and democratic governance and ultimately suggesting the existence of a positive right of democratic revolution under international law. Focusing on the Arab spring and the normative framework of the African Union, this article argues that the existing (emerging) human rights and democratic norms do not necessarily provide any distinct normative justifications for democratic revolutions beyond the legality that could be possibly established on the basis of traditional norms of international law. While the study recognizes emerging norms that represent a shift away from the effectiveness doctrine, it is observed that the pro-revolutionary implications of the norms are not as obvious as their importance as an (anti-revolutionary) injunction against the forcible ouster of democratically elected governments. The article concludes with the observation that the premium placed on democratic elections in the various normative instruments underscores the centrality of elections – and, alas, not revolutions – as the primary means through which the people's constitutive power (pouvoir constituant) is to be expressed.
China's Approaches to International Law since the Opium War
Authors: CHAN PHIL C. W.
Published: November 2014

International law is an amalgam of the past, present, and future. The past is important in itself not only because the vast majority of rules and principles of international law have come into being through decades, if not centuries, of deviation, crystallization and consolidation, but also because the past, and one's perspectives of the past, underlie, inform and explain a state's perspectives of a particular order or particular norms or values, and its approaches to the perspectives and actions of other states. The importance of understanding China's historical approaches to international law cannot be understated. China's interactions with international law began to take place in the context of its interactions with Western powers that culminated in the Opium War. This article then examines China's approaches to international law during its republican, communist, and contemporary socialist-market eras.
Beyond State Crimes: Non-State Entities and Crimes against Humanity
Authors: RODENHÄUSER TILMAN
Published: November 2014

Recent cases before the ICC raise the question of on behalf of which entities crimes against humanity can be committed. Interpreting the ‘organizational policy’ requirement in its context, this article argues that in principle crimes against humanity can be committed pursuant to or in furtherance of a policy of any organization that has the capacity to orchestrate a widespread or systematic attack against a civilian population. It is shown that this does not broaden the scope of the crime indefinitely but that concrete requirements defining such entities are found in the contextual elements of crimes against humanity.
Facial and Bodily Emotion Recognition in Multiple Sclerosis: The Role of Alexithymia and Other Characteristics of the Disease
Authors: Cecchetto Cinzia , Aiello Marilena , D’Amico Delia , Cutuli Daniela , Cargnelutti Daniela , Eleopra Roberto , Rumiati Raffaella Ida
Published: November 2014

Multiple sclerosis (MS) may be associated with impaired perception of facial emotions. However, emotion recognition mediated by bodily postures has never been examined in these patients. Moreover, several studies have suggested a relation between emotion recognition impairments and alexithymia. This is in line with the idea that the ability to recognize emotions requires the individuals to be able to understand their own emotions. Despite a deficit in emotion recognition has been observed in MS patients, the association between impaired emotion recognition and alexithymia has received little attention. The aim of this study was, first, to investigate MS patient’s abilities to recognize emotions mediated by both facial and bodily expressions and, second, to examine whether any observed deficits in emotions recognition could be explained by the presence of alexithymia. Thirty patients with MS and 30 healthy matched controls performed experimental tasks assessing emotion discrimination and recognition of facial expressions and bodily postures. Moreover, they completed questionnaires evaluating alexithymia, depression, and fatigue. First, facial emotion recognition and, to a lesser extent, bodily emotion recognition can be impaired in MS patients. In particular, patients with higher disability showed an impairment in emotion recognition compared with patients with lower disability and controls. Second, their deficit in emotion recognition was not predicted by alexithymia. Instead, the disease’s characteristics and the performance on some cognitive tasks significantly correlated with emotion recognition. Impaired facial emotion recognition is a cognitive signature of MS that is not dependent on alexithymia. (JINS, 2014, 19, 1–11)
Prevalence of thyroid dysfunction with adequate and excessive iodine intake in Hebei Province, People’s Republic of China
Authors: Tan Long , Sang Zhongna , Shen Jun , Liu Hua , Chen Wen , Zhao Na , Wei Wei , Zhang Guiqin , Zhang Wanqi
Published: November 2014

Objective

To explore (i) the prevalence of thyroid dysfunction in populations with adequate and excessive iodine intakes and (ii) the effect of iodine exposure on the prevalence of thyroid dysfunction.

Design

Cross-sectional study was conducted in Hebei in 2010. The population was classified as having adequate or excessive iodine intake according to the iodine concentration in drinking water. Demographic information was collected by questionnaire. Levels of serum thyroid hormones, thyroid autoantibodies and iodine in drinking water and urine were measured.

Setting

Villages with adequate or excessive drinking water iodine in Hebei Province, People’s Republic of China.

Subjects

A total of 854 men and women aged 20–50 years who had lived in the surveyed areas for over 5 years, including 348 from the adequate iodine area (AIA) and 506 from the excessive iodine area (EIA).

Results

Median urinary iodine concentration was 185 μg/l in AIA and 1152 μg/l in EIA. The prevalence of thyroid dysfunction in AIA was 10·3 %, which included 1·1 % with hypothyroidism and 8·1 % with subclinical hypothyroidism; and 20·6 % in EIA, which included 3·6 % with hypothyroidism and 13·6 % with subclinical hypothyroidism. The positive rates of thyroglobulin antibody were 16·1 % in AIA and 11·9 % in EIA; the positive rates of thyroperoxidase antibody were 20·7 % in AIA and 16·4 % in EIA.

Conclusions

Excessive iodine intake may lead to increased prevalence of biochemical thyroid dysfunction, especially biochemical hypothyroidism. This is not related to an increase in prevalence of thyroid antibodies. Women are more susceptible to iodine excess.
The relative contribution of layers of the Social Ecological Model to childhood obesity
Authors: Ohri-Vachaspati Punam , DeLia Derek , DeWeese Robin S , Crespo Noe C , Todd Michael , Yedidia Michael J
Published: November 2014

Objective

The Social Ecological Model (SEM) has been used to describe the aetiology of childhood obesity and to develop a framework for prevention. The current paper applies the SEM to data collected at multiple levels, representing different layers of the SEM, and examines the unique and relative contribution of each layer to children’s weight status.

Design

Cross-sectional survey of randomly selected households with children living in low-income diverse communities.

Setting

A telephone survey conducted in 2009–2010 collected information on parental perceptions of their neighbourhoods, and household, parent and child demographic characteristics. Parents provided measured height and weight data for their children. Geocoded data were used to calculate proximity of a child’s residence to food and physical activity outlets.

Subjects

Analysis based on 560 children whose parents participated in the survey and provided measured heights and weights.

Results

Multiple logistic regression models were estimated to determine the joint contribution of elements within each layer of the SEM as well as the relative contribution of each layer. Layers of the SEM representing parental perceptions of their neighbourhoods, parent demographics and neighbourhood characteristics made the strongest contributions to predicting whether a child was overweight or obese. Layers of the SEM representing food and physical activity environments made smaller, but still significant, contributions to predicting children’s weight status.

Conclusions

The approach used herein supports using the SEM for predicting child weight status and uncovers some of the most promising domains and strategies for childhood obesity prevention that can be used for designing interventions.
Measuring retirement savings adequacy: developing a multi-pillar approach in the Netherlands
Authors: KNOEF MARIKE , BEEN JIM , ALESSIE ROB , CAMINADA KOEN , GOUDSWAARD KEES , KALWIJ ADRIAAN
Published: November 2014

The Dutch pension system is highly ranked on adequacy. These rankings, however, are based on fictitious replacement rates for median income earners. This paper investigates whether the Dutch pension adequacy is still high when we take into account the resources that people really accumulate, using a large administrative data set. A comprehensive approach is followed: not only public and private pension rights, but also private savings and housing wealth are taken into account. Summed over all age- and socioeconomic groups we find a median gross replacement rate of 83% and a net replacement rate of 101%. At retirement age, 31% of all households face a gross replacement rate that is lower than 70% of current income. Public and occupational pensions each account for more than 35% of total pension annuities. Private non-housing assets account for 14% and imputed rental income from net housing wealth accounts for about 10%. Some vulnerable groups, such as the self-employed, have below average replacement rates. Results are fairly similar to results found in the UK, indicating that we should be careful in evaluating the adequacy of pensions systems on the basis of fictitious replacement rates.
A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4
Authors: Evstafieva A G , Garaeva A A , Khutornenko A A , Klepikova A V , Logacheva M D , Penin A A , Novakovsky G E , Kovaleva I E , Chumakov P M
Published: November 2014

Generation of energy in mitochondria is subjected to physiological regulation at many levels, and its malfunction may result in mitochondrial diseases. Mitochondrial dysfunction is associated with different environmental influences or certain genetic conditions, and can be artificially induced by inhibitors acting at different steps of the mitochondrial electron transport chain (ETC). We found that a short-term (5 h) inhibition of ETC complex III with myxothiazol results in the phosphorylation of translation initiation factor eIF2α and upregulation of mRNA for the activating transcription factor 4 (ATF4) and several ATF4-regulated genes. The changes are characteristic for the adaptive integrated stress response (ISR), which is known to be triggered by unfolded proteins, nutrient and metabolic deficiency, and mitochondrial dysfunctions. However, after a prolonged incubation with myxothiazol (13–17 h), levels of ATF4 mRNA and ATF4-regulated transcripts were found substantially suppressed. The suppression was dependent on the p53 response, which is triggered by the impairment of the complex III-dependent de novo biosynthesis of pyrimidines by mitochondrial dihydroorotate dehydrogenase. The initial adaptive induction of ATF4/ISR acted to promote viability of cells by attenuating apoptosis. In contrast, the induction of p53 upon a sustained inhibition of ETC complex III produced a pro-apoptotic effect, which was additionally stimulated by the p53-mediated abrogation of the pro-survival activities of the ISR. Interestingly, a sustained inhibition of ETC complex I by piericidine did not induce the p53 response and stably maintained the pro-survival activation of ATF4/ISR. We conclude that a downregulation of mitochondrial ETC generally induces adaptive pro-survival responses, which are specifically abrogated by the suicidal p53 response triggered by the genetic risks of the pyrimidine nucleotide deficiency.
IFN-γ induces aberrant CD49b+ NK cell recruitment through regulating CX3CL1: a novel mechanism by which IFN-γ provokes pregnancy failure
Authors: Li Z-Y , Chao H-H , Liu H-Y , Song Z-H , Li L-L , Zhang Y-J , Yang Y , Peng J-P
Published: November 2014

Interferon-γ (IFN-γ), a pleiotropic lymphokine, has important regulatory effects on many cell types. Although IFN-γ is essential for the initiation of uterine vascular modifications and maintenance of decidual integrity, IFN-γ administration can also cause pregnancy failure in many species. However, little is known about the effector mechanisms involved. In this study, using an IFN-γ-induced abortion mouse model, we reported that no Dolichos biflorus agglutinin lectin-positive uterine natural killer (uNK) cells were observed in the uteri from IFN-γ-induced abortion mice. By contrast, the percentage of CD3−CD49b+ NK cells in the uterus and blood from a foetal resorption group was significantly higher than that of the control group. Similarly, significantly upregulated expression of CD49b (a pan-NK cell marker), CX3CL1 and CX3CR1 (CX3CL1 receptor) was detected in the uteri of IFN-γ-induced abortion mice. Using isolated uterine stromal cells, we showed that upregulated expression of CX3CL1 by IFN-γ was dependent on a Janus family kinase 2-signal transducers and activators of transcription 1 (JAK2-STAT1) pathway. We further demonstrated the chemotactic activity of CX3CL1 in uterine stromal cell conditioned medium on primary splenic NK cells. Finally, we observed increased recruitment of CD49b+ NK cells into the endometrium after exogenous CX3CL1 administration. Collectively, our findings indicate that IFN-γ can significantly increase uterine CX3CL1 expression via activation of the JAK2-STAT1 pathway, thus inducing CD49b+ NK cell uterine homing, and eventually provoke foetal loss. Thus, we provide a new line of evidence correlating the deleterious effects of IFN-γ on pregnancy with the aberrant regulation of CX3CL1 and CD49b+ NK cells.
Cafestol overcomes ABT-737 resistance in Mcl-1-overexpressed renal carcinoma Caki cells through downregulation of Mcl-1 expression and upregulation of Bim expression
Authors: Woo S M , Min K-j , Seo B R , Nam J-O , Choi K S , Yoo Y H , Kwon T K
Published: November 2014

Although ABT-737, a small-molecule Bcl-2/Bcl-xL inhibitor, has recently emerged as a novel cancer therapeutic agent, ABT-737-induced apoptosis is often blocked in several types of cancer cells with elevated expression of Mcl-1. Cafestol, one of the major compounds in coffee beans, has been reported to have anti-carcinogenic activity and tumor cell growth-inhibitory activity, and we examined whether cafestol could overcome resistance against ABT-737 in Mcl-1-overexpressed human renal carcinoma Caki cells. ABT-737 alone had no effect on apoptosis, but cafestol markedly enhanced ABT-737-mediated apoptosis in Mcl-1-overexpressed Caki cells, human glioma U251MG cells, and human breast carcinoma MDA-MB231 cells. By contrast, co-treatment with ABT-737 and cafestol did not induce apoptosis in normal human skin fibroblast. Furthermore, combined treatment with cafestol and ABT-737 markedly reduced tumor growth compared with either drug alone in xenograft models. We found that cafestol inhibited Mcl-1 protein expression, which is important for ABT-737 resistance, through promotion of protein degradation. Moreover, cafestol increased Bim expression, and siRNA-mediated suppression of Bim expression reduced the apoptosis induced by cafestol plus ABT-737. Taken together, cafestol may be effectively used to enhance ABT-737 sensitivity in cancer therapy via downregulation of Mcl-1 expression and upregulation of Bim expression.
Exciton-like electromagnetic excitations in non-ideal microcavity supercrystals
Authors: Rumyantsev Vladimir , Fedorov Stanislav , Gumennyk Kostyantyn , Sychanova Marina , Kavokin Alexey
Published: November 2014

We study localized photonic excitations in a quasi-two-dimensional non-ideal binary microcavity lattice with use of the virtual crystal approximation. The effect of point defects (vacancies) on the excitation spectrum is investigated by numerical modelling. We obtain the dispersion and the energy gap of the electromagnetic excitations which may be considered as Frenkel exciton-like quasiparticles and analyze the dependence of their density of states on the defect concentrations in a microcavity supercrystal.
Pt-free solar driven photoelectrochemical hydrogen fuel generation using 1T MoS2 co-catalyst assembled CdS QDs/TiO2 photoelectrode
Authors: Raja R. , Sudhagar P. , Devadoss Anitha , Terashima C. , Shrestha L. K. , Nakata K. , Jayavel R. , Ariga K. , Fujishima A.
Published: November 2014

Herein, Pt-free solar hydrogen generation was achieved using TiO2–CdS photoelectrodes with a metallic-type 1T MoS2 co-catalyst in a back-to-back electrode architecture.
Reversible biomechano-responsive surface based on green fluorescent protein genetically modified with unnatural amino acids
Authors: Longo Johan , Yao Chunyan , Rios César , Chau Nguyet Trang Thanh , Boulmedais Fouzia , Hemmerlé Joseph , Lavalle Philippe , Schiller Stefan M. , Schaaf Pierre , Jierry Loïc
Published: November 2014

Uniaxial stretching of modified GFP “clicked” onto an elastomer leads to a repeatable and reversible decrease of its fluorescence intensity.