bluuebunny/crossref_metadata_2025 huggingface dataset:
Efecto en la microdureza de resinas compuestas aplicando un recubrimiento de nanopartículas de plata inmersas en un adhesivo hidrofílico
Authors: López Flores Alejandra Itzel , González Flores Andrea , Scougall Vilchis Rogelio José , Toral Rizo Víctor Hugo , Jiménez Iniesta Daniel
Published: June 2022

La nanotecnología está dirigida a la fabricación de partículas con propiedades únicas; en las resinas compuestas se mejoran las propiedades mecánicas, se amplía la vida útil y aumentan sus propiedades antibacterianas. Objetivo: Conocer el efecto que tienen las nanopartículas de Ag en la microdureza Vickers de las resinas compuestas. Hipótesis: las nanopartículas de plata inmersas en un adhesivo hidrofílico producen mayor microdureza Vickers en las resinas compuestas. Material y métodos: Se realizó un total de 15 bloques de resina compuesta en moldes cúbicos, cinco fabricados con resina compuesta per se (GI), cinco fabricados de resina compuesta aplicando un recubrimiento de un agente adhesivo hidrofílico (GII), cinco fabricados de resina compuesta con un recubrimiento de (NPs Ag) inmersas en un agente adhesivo hidrofílico (GIII). En cada grupo se analizaron 50 indentaciones. El análisis estadístico se realizó utilizando la prueba ANOVA de un factor con significancia predeterminada con un valor de p ≤ 0.05. Además, se evaluó el cambio de color de los bloques de resina compuesta. Resultados: El valor de microdureza Vickers en el GIII (recubrimiento con NPs Ag inmersas en un agente adhesivo hidrofílico) fue significativamente superior comparado con los demás grupos. Sin embargo, se observó la presencia de pigmentaciones de color blanco sobre los bloques donde fue aplicado el recubrimiento de (NPs Ag). Conclusiones: Agregar un recubrimiento de (NPs Ag) inmersas en un adhesivo hidrofílico aumenta significativamente la microdureza Vickers; como efecto adverso produce cambios de color en la superficie donde fue aplicado.
Medio de transporte con y sin la adición de anfotericina B en la viabilidad de las células de la pulpa dental
Authors: Gavidia Pacheco Angela G , Ayón Haro Esperanza R
Published: June 2022

Introducción: El estudio de las células madre es un tema de gran interés en el campo de la investigación y de la medicina regenerativa. Una de las fuentes de obtención de las células madre es la pulpa dental humana, la cual se puede conseguir con procedimientos sencillos y poco invasivos. Para que el aislamiento de células de la pulpa dental sea exitoso, es de vital importancia seguir protocolos estrictos, teniendo en cuenta las técnicas y los cuidados necesarios para evitar la contaminación desde el momento de la extracción de la pieza dental hasta su entrega en el medio de transporte. Debido a ello, en esta investigación el objetivo fue comparar dos medios de transporte y evaluar la viabilidad celular en ambos grupos. Material y métodos: Se compararon dos grupos, el grupo 1 fue transportado en un medio con los antibióticos penicilina-estreptomicina; en el grupo 2 se utilizó un medio de transporte con los antibióticos ya mencionados más la adición de anfotericina B. Se recolectaron 33 piezas dentales de pacientes entre 18 y 29 años de edad. Para la evaluación de la viabilidad celular se utilizó el colorante azul de tripán. Luego se realizó el conteo celular en un hemocitómetro en el microscopio. Resultados: Al análisis estadístico se obtuvo que el número de células y la viabilidad celular fue mayor en el grupo 2 que en el grupo 1. Existió una diferencia estadísticamente significativa entre ambos grupos. Conclusiones: Se obtuvo mayor cantidad de células viables al utilizar la anfotericina B en el medio de transporte.
Climate Change Prediction Using ARIMA Model
Authors: M Navaneetha Krishnan , R Ranjith , B Lavanya
Published: June 2022

Abstract: It is a challenging task to forecast weather data accurately. The temperature change has important implications for business and economic activity. Effective management of global climate change impacts will depend upon accurate and costeffective forecasts. This paper univariate statistic techniques to model the properties of a world mean temperature dataset to develop a parsimonious forecasting model for managerial decision-making over the short-term horizon and the ARIMAbased prognostication tool has been developed by implementing the ARIMA algorithm in python. Although the model is estimated on global temperature data, the methodology could even be applied to temperature data at more localized levels. The statistical techniques include seasonal and non-seasonal unit root testing with and without structural breaks as well as ARIMA and SARIMA modelling. This paper helps us to predict the air temperature, which is the main problem of global warming. Prediction of the likely impact of climate change on monthly mean maximum and minimum temperature in Tamilnadu. Time-series techniques to develop a parsimonious model of global mean temperature change that can be used to forecast over the short-term horizon (5- 10) years. Keywords: Global warming, Forecasting, temperature
A Case Report of Korean Medical Intervention in a Patient with Myasthenia Gravis after Myasthenia Crisis
Authors: Kim Yeseul , Park Jiyoon , Min Seonwoo , Moon Jiseong , Hong Junghwa , Ahn Lib , Choi Dongjun
Published: June 2022

Objective: This study reports on the management of a patient with myasthenia gravis (MG) following myasthenic crisis (MC) using Korean medicine.Methods: A 77-year-old Class Ⅴ MG patient was treated with acupuncture, moxibustion, and Korean herbal medicine. A manual muscle test was used to derive a Medical Research Council (MRC) score and the patient’s subjective view of his dyspnea was measured to assess MG symptoms.Results: The MRC grade indicated significant deterioration after 65 days of treatment, although there was no change in the patient’s subjective dyspnea assessment. But no other MG or MC complications occurred.Conclusion: This study suggests that Korean medicine could be used for the management of Class Ⅴ MG patients.
Hubungan Antar Agama menurut Al-Quran dan Hadis
Authors: Marzatillah Marzatillah , Wahid Abd.
Published: June 2022

Sensitive issues that occur today are the relationship between religions that are not harmonious, the birth of Islamophobia among non-Muslims has given birth to a negative stigma against Islam, this is due to their misunderstanding of the teachings of Islam. This condition has resulted in disharmony in the social life of the community and even the emergence of hostility. This paper seeks to clarify the misunderstanding of non-Muslims toward Islam by explaining the concept of tolerance in the Qur'an and the Sunnah of the Prophet. The results of the study show that in terms of humanity, Islam is very tolerant and upholds human values, while in matters of religious belief, Islam provides limits so that it does not fall into shirk because it is a big sin that is not forgiven by Allah swt. Isu sensitif yang terjadi saat ini adalah hubungan antar agama yang tidak harmonis, lahirnya islamophopia di kalangan non muslim telah melahirkan stigma negatif terhadap Islam, hal diakibatkan kesalah pahaman mereka terhadap ajaran Islam. kondisi ini telah mengakibatkan terjadinya disharmonis dalam kehidupan sosial masyarakat bahkan munculnya permusuhan. Tulisan ini berupaya memperjelas kesalah pahaman kalangan non muslim terhadap Islam dengan menjelaskan konsep toleransi dalam Alquran dan Sunnah Rasul. Hasil penelitian menunjukkan bahwa dalam hal kemanusian, Islam sangat toleran dan menjunjung tinggi nilai-nilai kemanusian, sedangkan dalam persoalan keyakinan beragama, Islam memberi batasan agar agar tudak terjerumus dalam kesyirikan, karena hal itu merupakan dosa besar yang tidak diampunkan oleh Allah swt.
Problems of ESG-Reorganization of Russian Metallurgical Corporations
Authors: Tsygalov Yu. M.
Published: June 2022

The development of environmental programs in modern conditions is characterized by the ESG transformation of the economy. In the EU, which is the most important importer of Russian steel products, a new carbon tax will be levied from 2025–2026, which will increase the costs of domestic producers by more than 20%. The peculiarity of the new tax is that it applies to the industry value chain, including suppliers and consumers of metal, which jeopardizes other sectors of the national economy.

The purpose of the study is to identify the problems and risks generated by the transition of Russian ferrous metallurgy companies to ESG principles of management. The object of research is ESG transformation of the economy. The subject of the study is the problems and risks of the Russian ferrous metallurgy formed by the ESG transformation. General scientific methods were used, such as: analysis, synthesis, abstraction, modeling, generalization. It is established that the ESG transformation of the economy makes the restructuring of Russian metallurgical companies inevitable. At the same time, domestic companies lag behind Western ones in the development of technologies that lead to a zero carbon footprint. Inefficient work to reduce the carbon footprint leads to the payment of carbon tax on foreign markets, fines on the domestic market, prevents the receipt of “green” financing. Starting from 2026, the financial condition of metallurgical companies will rapidly deteriorate. The implementation of the Targeted (intensive) development scenario provided for by the “Strategy of Socio-economic Development of the Russian Federation with low Greenhouse Gas Emissions until 2050” and the active support of the state will help to maintain the position in the markets.
Analysis of Trends in the Higher Education and Science as the Basis for Strategizing the Scientific and Innovative Activities in Regional Universities
Authors: Pahomova E. A.
Published: June 2022

Aim of the article is to identify global, national and local trends in the development of higher education and science, which should be taken into account when strategizing the scientific and innovative activities of a regional university (in the conditions of the Kemerovo region — Kuzbass).

Materials and methods. The methodological and theoretical basis of the study is the theory of strategy and the strategy methodology developed by V. L. Kvint (Moscow State University named after M. V. Lomonosov), which made it possible to substantiate the analysis of opportunities and threats as the initial stage of strategizing the scientific and innovative activities of a regional university. The methods of OTSW-analysis, economic-statistical analysis, comparative analysis were used Analytical and forecast documents of authoritative Russian and international organizations dealing with the problems of science and higher education were used.

results. 12 trends of various levels are identified that determine the opportunities and threats for the strategic development of scientific and innovative activities in the universities of the Kemerovo region — Kuzbass. At the global level, these include a decrease in demand for higher education and the need for scientific and innovative diversification; the growth of the global research and development market, especially in certain niches; growth in the share of research and development funding by commercial organizations; influence on the research topics of the international agenda, including the UN sustainable development goals. The main national trends are instability and limited funding for research and development, the growing interest of the state in fundamental research; maintaining a low level of integration of universities with business with the growth of the innovative activity of the latter; the growing stratification of the domestic higher education. In the Kemerovo region — Kuzbass, the most important trends are the structural transformation of the traditional university system with increased competition among universities; limited demand for research and development, not corresponding to the economic importance of the region; creation of institutional foundations for the development of scientific and innovative activities and the strategic goals of Kuzbass for scientific and technological development, which determine promising areas of research.

Conclusions. Based on the analysis of strategically significant trends, the first stage of the OTSW analysis was implemented, the opportunities and threats that determine the strategic development of research activities of the universities of the Kemerovo region — Kuzbass were identified.
CASAMENTO CIVIL E MODELO DE FAMÍLIA NO MUNICÍPIO DE CRUZEIRO(SC): mudanças e permanências no contexto da laicização do estado brasileiro sob uma ótica histórico-constitucional
Authors: Magnus Petiz Martin , De Sant'Ana Petiz Silmei
Published: June 2022

A dogmática constitucional, fundada no dado histórico de que a Primeira República tornou o Estado laico, considera indubitável creditar a tal regime a resolução de tal questão em nossa sociedade. Contudo, tendo em vista a adoção de um marco teórico que conjuga a investigação histórica empírica com a análise dos eventos que geraram a suposta transformação social com o novo regime constitucional de 1891, o presente trabalho busca demonstrar contradições entre o projeto constituinte e o seu desenvolvimento. Isso será feito por meio do estudo dos registros civis de casamento do Município de Cruzeiro/SC – que, como se verá, deu origem a muitos outros municípios –, uma vez que o tema do casamento civil era recente, ensejando polêmicas com a Igreja Católica.
ESTUDOS ORGANIZACIONAIS: por uma teorização crítica da empresa a partir do ferramental habermasiano
Authors: Alfaya Natalia Maria Ventura da Silva , Tiroli Luiz Gustavo
Published: June 2022

Os estudos organizacionais, inicialmente vinculados às disciplinas de engenharia e administração, a partir do século XX, adquiri novos significados a partir da incorporação das organizações como objeto de estudo de áreas como a filosofia e a sociologia, haja vista que a natureza complexa e dinâmica da organização impacta diversos segmentos e dimensões da sociedade. Destaque para a filosofia habermasiana que, apesar de não ser originalmente direcionada para o campo da administração, permite que se estenda o arcabouço teórico para outros objetos de estudos, dada a extensão e profundidade da obra de Habermas. Neste contexto, haveria espaço para a construção de uma perspectiva empresarial para além da lógica instrumental-estratégica? De que maneira o ferramental habermasiano pode contribuir para a teorização crítica da empresa?  O objetivo consiste em perquirir na teoria do agir comunicativo habermasiana um aporte teórico capaz de construir uma teoria crítica organizacional. A natureza da pesquisa é inicial, valendo-se do procedimento metodológico dedutivo e da técnica de revisão bibliográfica. O primeiro tópica versa sobre uma abordagem multidisciplinar da teoria das organizações para além dos aspectos tradicionais. O segundo discorre sobre a filosofia habermasiana e os principais conceitos operacionais da teoria do agir comunicativo. Por fim, o terceiro perquire sobre a teorização crítica da empresa a partir do aporte da teoria do agir comunicativo habermasiana. Nas considerações finais, vislumbra-se a possibilidade da teoria habermasiana possibilitar um redimensionamento da concepção de empresa para além das percepções tradicionais, estratégicas e instrumentais, em uma perspectiva comunicativa e emancipatória.
LOS MOVIMIENTOS MIGRATORIOS DESDE CENTROAMÉRICA: Perspectiva jurídica y securitaria
Authors: Calvillo Cisneros José Miguel
Published: June 2022

Las migraciones desde Centroamérica hacia el Norte han aumentado en los últimos años. Este crecimiento se produce en un contexto de inestabilidad política, incremento de la violencia y de la inseguridad ciudadana y deterioro de la situación económica en la región.Existen figuras jurídicas adecuadas que ofrecen amparo a estas poblaciones como la protección temporal o el reconocimiento prima facie. La concesión de estas figuras depende de la voluntariedad de los Estados, pero la protección, si se demuestra que existen fundados temores para la vida, pasaría a ser una cuestión de Derechos Humanos y no de discrecionalidad política.

Si se consigue demostrar los fundados temores de riesgo para la vida del migrante y/o la de su familia por las razones especificadas en la Convención de Ginebra y en su Protocolo de Nueva York, los Estados en tránsito y/o de destino deben hacer cumplir el Derecho Internacional de los Refugiados otorgando la cobertura necesaria para proteger sus vidas. En el caso de no quedar demostrados estos fundados temores para su vida y/o la de su familia, será la voluntariedad de los Estados la que determine el nivel de protección jurídica y política que ha de brindarse.
A VIOLÊNCIA INSTITUCIONAL E O MITO DA DEMOCRACIA RACIAL DE UM PONTO DE VISTA JURÍDICO
Authors: Soares Paulo Sérgio Gomes , Oliveira Tarsis Barreto , Pereira Maria Cotinha Bezerra
Published: June 2022

O artigo aborda a temática do racismo institucional para analisar a dinâmica de segregação e discriminação da população negra no judiciário, mesmo em face da afirmação dos Direitos Humanos. O problema é histórico e tem origem no mito da democracia racial que mascarou o racismo, exigindo uma análise macrossociológica que retoma os reflexos da escravidão e da violência colonial nas relações sociais reproduzidas em instituições sociais como um legado da dominação branca para a manutenção do status quo e subjugo dos negros, dificultando a garantia dos Direitos Humanos. O objetivo do artigo é mostrar que o mito da democracia racial se mantém vivo devido ao longo processo de introjeção cultural da ideologia dominante. O racismo se imiscuiu na seara jurídica e as contradições se evidenciam pelos discursos e atuação dos juízes que podem ceder à pressão da rotulagem e do estigma social para proferir a pena a partir do estereótipo.
DISCURSO DO DESENVOLVIMENTO ECONÔMICO COMO MECANISMO LEGITIMADOR DA RESOLUÇÃO NEGOCIADA DE CONFLITOS AMBIENTAIS NO BRASIL
Authors: Duarte Vieira Joao Leonardo , Cançado Anaya Felisa
Published: June 2022

Após o término da Segunda Guerra Mundial, verifica-se a proeminência do que se denominou como “Paradigma econômico do desenvolvimento”, o qual apresenta-se como um fenômeno político fonte de vários questionamentos em virtude de seu aspecto neocolonial e suas graves consequências sociais, econômicas e culturais. Desse modo, o intuito do trabalho é verificar a relação existente entre a ideia de um desenvolvimento pautado por aspectos estritamente econômicos e a resolução negociada de conflitos ambientais no Brasil enquanto uma política de Estado, notadamente no que tange à necessidade de se estabelecer uma visão crítica acerca da utilização desses mecanismos consensuais no campo ambiental. No que refere à metodologia, o trabalho apresenta pesquisa bibliográfica, fundamentada em autores como Bourdieu (2014), Esteva (2000), Gudynas (2015) e Zhouri (2019). Os resultados da pesquisa indicam que o Paradigma do desenvolvimento econômico operou – e ainda opera - como mecanismo de legitimação da resolução negociada de conflitos ambientais no Brasil, contribuindo para o apagamento de assimetrias e docilização dos sujeitos.
TANTANGAN, KENDALA, DAN KESIAPAN PEMASARAN ONLINE UMKM DI DESA NGLEBAK, KECAMATAN TAWANGMANGU, KABUPATEN SUKOHARJO
Authors: Rokhmah Betty Eliya , Yahya Ismail
Published: June 2022

Nglebak Village is one of the Villages in Sukoharjo Regency which has the potential to be used as a model for SME centers because this village has many entrepreneurs and artisans in it. To achieve this goal SMEs must be prepared to meet broader marketing. Analysis is needed related to the challenges, obstacles, and how the readiness of the MSMEs in marketing, especially online marketing. SMEs readiness in conducting online marketing signifies the readiness of SMEs to serve consumers with wider reach and greater numbers. From the analysis conducted, it is known that the challenges faced by the Nglebak Village SMEs are competition from within and outside the country, the constraints are in terms of capital and lack of marketing knowledge. If these challenges and obstacles cannot be overcome, Nglebak Village SMEs can be said to be not ready to implement online marketing and serve consumers with a wide reach.Desa Nglebak merupakan salah satu Desa di Kabupaten Sukoharjo yang memiliki potensi untuk dijadikan model sentra UMKM dikarenakan Desa ini mempunyai banyak pengusaha dan pengrajin didalamnya. Untuk mencapai tujuan ini UMKM harus siap untuk memenuhi pemasaran yang lebih luas. Dibutuhkan analisis terkait dengan tantangan, kendala, dan bagaimana kesiapan dari UMKM tersebut dalam melakukan pemasaran terutama pemasaran online. Kesiapan UMKM dalam melakukan pemasaran online menandakan kesiapan UMKM untuk melayani konsumen dengan jangkauan lebih luas dan jumlah yang lebih banyak. Dari analisis yang dilakukan diketahui bahwa tantangan yang dihadapi oleh UMKM Desa Nglebak adalah persaingan dari dalam maupun luar negeri, kendalanya adalah dari segi modal dan pengetahuan tentang pemasaran yang masih kurang. Apabila tantangan dan kendala tersebut tidak bisa diatasi maka UMKM Desa Nglebak dapat dikatakan belum siap untuk menerapkan pemasaran online dan melayani konsumen dengan jangkauan luas.
The genomic analysis of Southwest Asian indigenous goats revealed evidence of ancient adaptive introgression related to desert climate
Authors: Nanaei Hojjat Asadollahpour , Cai Yudong , Wen Jiayue , Alshawi Akil , Essa Abdulameer , Hussain Tanveer , Fu Weiwei , Lenstra Johannes A. , Wang Xihong , Jiang Yu
Published: June 2022

Understanding how evolutionary pressures relating to climate changes
have shaped the genetic background of present day domestic animals is a
fundamental pursuit in biology. Here, we generated whole genome sequence
data from native goat populations in Iraq and Pakistan countries.
Together with published data from worldwide modern, historical remains
and wild caprid species (including ibex like species, bezoar and markhor
goats) we explore genetic population structure, ancestry components and
signatures of natural positive selection of native goat populations in
Southwest Asia (SWA) region. Our results revealed that the genetic
structure of SWA goats was deeply influenced by the gene flow from
eastern Mediterranean area during the Chalcolithic period, which may
reflect the adaptation to the gradual warming and aridity in this
region. Furthermore, a comparative genomic analysis revealed adaptive
introgression of KITLG locus from the Nubian ibex (Capra nubiana) into
African and SWA goats. The frequency of the selected allele at this
locus was found significantly higher among the goat populations located
close to the north-east of Africa. The Nubian ibex is a wild relative of
the domestic goat that is well adapted to the arid mountains of north
Africa and the Middle East. These results provide new insights into the
genetic composition and history of goat populations in SWA region.
Variation in the rate of phenotypic plasticity among ectotherms
Authors: Einum Sigurd , Burton Tim
Published: June 2022

An individual’s fitness cost associated with environmental change
depends on the rate of adaptive phenotypic plasticity, and yet our
understanding of plasticity rates in an ecological and evolutionary
context remains limited. We provide the first quantitative synthesis of
existing plasticity rate data, focusing on acclimation of temperature
tolerance in ectothermic animals, where we demonstrate applicability of
a recently proposed analytical approach. The analyses reveal
considerable variation in plasticity rates of this trait among species,
with half-times (how long it takes for the initial deviation from the
acclimated phenotype to be reduced by 50% when individuals are shifted
to a new environment) ranging from 3.7 to 770.2 h. Furthermore, rates
differ among higher taxa, being higher for amphibians and reptiles than
for crustaceans and fishes, and with insects being intermediate. We
argue that a more comprehensive understanding of phenotypic plasticity
will be attained through increased focus on the rate parameter.
Rapid progression to Richter’s syndrome in a patient with chronic lymphocytic leukemia and near-triploid karyotype
Authors: Dencic-Fekete Marija , Terzic Tatjana , Jakovic Ljubomir , Djurasinovic Vladislava , Djurasevic-Karan Teodora , Radojkovic Milica , Pavlovic Sonja , Bogdanovic Andrija
Published: June 2022

Introduction. The presence of aneuploidy in patients diagnosed with chronic lymphocytic leukemia (CLL), except trisomy 12, is considered quite uncommon. Hyperdiploidy or near-tetraploidy (occurring in 1?3% of all CLL patients) usually confer a poor prognosis. Case report. We report a patient in a progressive phase of CLL with near?triploid karyotype. The prognosis of the disease was more precisely determined by applying the cytogenetic analysis of the karyotype and was complemented with molecular methods and pathohistological examination. The complex karyotype was accompanied by the TP53, C-MYC, and IGH gene disruptions, the most probable cause of rapid evolution into Richter?s syndrome. Conclusion. The use of comprehensive contemporary diagnostic techniques is highly recommended in patients who are in the progressive phase of CLL, primarily for the adequate choice of management strategy. The presented case confirms that aneuploidy in CLL patients indicates poor prognosis, which is in accordance with previous publications reporting on cases of CLL patients with aneuploidy.
Dietary Protein Sources, Mediating Biomarkers, and Incidence of Type 2 Diabetes: Findings from the Women’s Health Initiative and the UK Biobank
Authors: Li Jie , Glenn Andrea J. , Yang Qingling , Ding Ding , Zheng Lingling , Bao Wei , Beasley Jeannette , LeBlanc Erin , Lo Kenneth , Manson JoAnn E. , Philips Lawrence , Tinker Lesley , Liu Simin
Published: June 2022

  

Objective 

Whether and how dietary protein intake is linked to type 2 diabetes (T2D) remains unclear. This study aimed to investigate the associations of protein intake with the development of T2D and the potential mediating roles of T2D biomarkers. 

Research Design and Methods

We included 108,681 postmenopausal women without T2D at baseline from the Women’s Health Initiative (WHI) (primary cohort) and 34,616 adults without T2D from the UK Biobank (UKB) (replication cohort). Cox proportional hazard models were used to estimate the protein-T2D associations. Mediation analysis was performed to assess the mediating roles of biomarkers in case-control studies nested in the WHI. 

Results

In the WHI, 15,842 incident T2D cases were identified during a median follow-up of 15.8 years. Intake of animal protein was associated with increased T2D risk (Hazard ratio, HR comparing the highest to the lowest quintile=1.31, 95% confidence interval [1.24–1.37]), while plant protein with decreased risk (HR: 0.82 [0.78–0.86]). Intakes of red meat, processed meat, poultry, and eggs were associated with increased T2D risk, while whole grains with decreased risk. Findings from the UKB were similar. These findings were materially attenuated after additional adjustment for body mass index. Substituting 5% energy from plant protein for animal protein was associated with 21% decreased T2D risk (HR: 0.79 [0.74–0.84]), which was mediated by levels of hs-CRP, interleukin-6, leptin, and SHBG.

Conclusions 

Findings from these two large prospective cohorts support the notion that substituting plant protein for animal protein may decrease T2D risk mainly by reducing obesity-related inflammation.
Hyperinsulinemia is highly associated with markers of hepatocytic senescence in two independent cohorts
Authors: Meijnikman Abraham S. , Olden Casper C. van , Aydin Omrum , Herrema Hilde , Kaminska Dorota , Lappa Dimitra , Männistö Ville , Tremaroli Valentina , Olofsson Louise E. , Brauw Maurits de , Laar Arnold van de , Verheij Joanne , Gerdes Victor E. A. , Schwartz Thue W. , Nielsen Jens , Bäckhed Fredrik , Pajukanta Päivi , Pihlajamäki Jussi , Tchkonia Tamar , Kirkland James L. , Kuipers Folkert , Nieuwdorp Max , Groen Albert K.
Published: June 2022

  

Cellular senescence is an essentially irreversible growth arrest that occurs in response to various cellular stressors and may contribute to development of type 2 diabetes and Non-Alcoholic Fatty Liver Disease (NAFLD). Here, we investigated whether chronically elevated insulin levels are associated with cellular senescence in the human liver.

In 107 individuals undergoing bariatric surgery, hepatic senescence markers were assessed by immunohistochemistry as well as transcriptomics. A subset of 180 participants from the ongoing Finnish Kuopio OBesity Surgery (KOBS) study was used as validation cohort.

We found plasma insulin to be highly associated with various markers of cellular senescence in liver tissue. The liver transcriptome of individuals with high insulin revealed significant upregulation of several genes associated with senescence: p21, TGFβ, PI3K, HLA-G, IL8, p38, Ras, and E2F. Insulin associated with hepatic senescence independently of NAFLD and plasma glucose. By using transcriptomic data from the KOBS study, we could validate the association of insulin with p21 in the liver.

Our results support a potential role for hyperinsulinemia in induction of cellular senescence in the liver. These findings suggest possible benefits of lowering insulin levels in obese individuals with insulin resistance.
NRF2 Genetic Polymorphism Modifies the Association of Plasma Selenium Levels With Incident Coronary Heart Disease among Type 2 Diabetes Individuals
Authors: Jia Chengyong , Wang Ruixin , Long Tengfei , Xu Yali , Zhang Ying , Peng Rong , Zhang Xiaomin , Guo Huan , Yang Handong , Wu Tangchun , He Meian
Published: June 2022

  

Existing studies found that both plasma selenium and NRF2 promoter variants (e.g., rs6721961) were associated with cardiovascular disease risk in the general population. However, epidemiological evidence on the interaction between plasma selenium and NRF2 genetic susceptibility in relation to incident coronary heart disease (CHD) risk remains scarce, especially among individuals with type 2 diabetes (T2D). Thus, we examined whether rs6721961 in the NRF2 gene might modify the association between plasma selenium levels and incident CHD risk among T2D. During a mean (SD) follow-up period of 6.90 (2.96) years, 798 incident CHD cases were identified in 2,251 T2D cases. Risk allele carriers (GT/TT) of rs6721961 showed a higher risk of incident CHD among T2D (adjusted HR = 1.17, 95% CI: 1.02–1.35) vs. non-risk allele carriers (GG). Each 22.8 μg/L increase in plasma selenium levels was associated with a reduced risk of incident CHD among T2D with risk allele (GT/TT; HR = 0.80, 95% CI: 0.71–0.89), whereas no association was found in those with non-risk allele (GG; Pinteraction = 0.004), indicating that NRF2 promoter polymorphism might modify the association between plasma selenium levels and incident CHD risk among T2D. Our study suggests that redox-related genetic variants should be considered to identify populations that might benefit most from selenium supplementation. Further mechanistic studies are warranted.
Portrait of A Muse: A biographical novel about the eighteenth century poet, Anna Seward, of Lichfield (England), with an accompanying critical essay: The Grave of the Muse is the Marriage Bed
Authors:   ,   Swansea University, Dickson Susan
Published: June 2022

Introduction 'What does the life of Anna Seward tell us about factors which influenced female literary success in the patriarchal world of the later eighteenth century?' This is my central research question, investigated through my novel and this accompanying exegesis, where I also consider other aspects of the project relevant to both Anna's history and my re-creation of it through biographical fiction. In the first part of the essay, I examine the genesis of my semi-fictional biographical novel, Portrait of a Muse, which samples the life of Anna Seward (1742-1809), an English provincial poet, who became known as ‘The Swan of Lichfield’. I explore issues of methodology and literary contexts, including my novel's relationship to recent historical and biographical fiction, along with stylistic links to early English novels and the Gothic tradition. I elaborate on research findings, characterisation and aspects of social history including portrait-painting and medical matters, along with other elements of my writing journey. The second part of the essay examines in detail Seward’s relationships and her situation as an unmarried woman, relatively independent and able to succeed in her chosen career. Through the medium of Seward’s letters and poems, including her seminal work, the verse-novel Louisa, I investigate her attitudes to romantic love versus 'mercenary' marriage, and I discuss how Louisa reflects much of Anna's own life story. I compare Anna's circumstances to other important female writers of the era. A thesis overview presents the important aspects of my PhD project, and demonstrates how I have contributed not only to the field of knowledge relating to Anna Seward and her contemporaries, but also to wider aspects of social history. I return to my research question with a summary of my findings. Finally, in a brief epilogue, I use a short fictional scenario to compare Seward’s life story with my own situation as a middle-class educated woman in the twenty-first century.
Traducciones de las educadoras diferenciales en torno a las políticas de inclusión escolar en el mercado educativo chileno
Authors: Inostroza Inostroza Fabián Andrés
Published: June 2022

Desde la dictadura cívico-militar, el sistema escolar chileno ha sido regulado como un mercado educativo, modelo que ha aumentado la exclusión del estudiantado, aspecto que en los últimos años se ha intentado revertir por medio de políticas de inclusión, implementadas principalmente por las educadoras diferenciales en las escuelas. El objetivo de esta investigación es conocer las traducciones que las educadoras diferenciales producen respecto de estas legislaciones. Entre los hallazgos, se detecta una valoración ambivalente de la política, ya que, si bien destacan el aumento de los recursos dirigidos a la educación especial, critican el hecho de que la inclusión se regule a través de subsidios. En segundo lugar, manifiestan que las legislaciones de inclusión refuerzan una mirada clínica hacia la diversidad del alumnado. Y, por último, las docentes detectan que estas leyes generan prácticas de exclusión de alumnos de acuerdo con el rendimiento académico de estos en pruebas estandarizadas.
Development of Student Worksheets Based on Contextual Teaching and Learning (CTL) on Heat Transfer
Authors:   Education Study Program, Master of Physics Education, Faculty of Teacher Training and Education, Sriwijaya University Palembang, Indonesia, Nurazri Mudalfy Etyanna , Mabruroh Faizatul ,   Lecturer of Physics Education, State Islamic University, Palembang, Indonesia, Samiha Yulia Tri ,   Lecturer at State Islamic University, Palembang, Indonesia, Fathurohman Apit ,   Lecturer of Master of Physics Education, Sriwijaya University, Palembang, Indonesia
Published: June 2022

This research had a purpose to result in student's activity sheet based on contextual teaching and learning toward movement of heat subject that validate, practical. The research method used developing on 4d model. This research held on even semester in 2019 experts validation show that the student's activity sheet had been fulfilled of valid criteria with 84.583% for material and design aspect is 82.5%. The small group trial resulted in an average value of 91, 18%. The result of this research showed that student's activity sheet based on contextual teaching and learning toward movement of heat subject had been fulfilled of valid criteria.
Difference of Complete Blood Count (CBC) between Patient with Sudden Deafness and Control at Sanglah General Hospital from January 2018-March 2021
Authors: Sylvia Sylvia , Wiranadha Made
Published: June 2022

Introduction: Sudden deafness is sudden sensorineural hearing loss (SSNHL) of at least 30 db or more in three contiguous frequencies, occurring within 72 hours. 10-15% is caused by underlying disease, while the others are idiopathic. Prognosis are difficult to predict. Complete blood count (CBC) is a basic examination that can be done in almost all medical facility. Few researches have shown a significant difference in hematocrit, NLR,PLR, MLR, RDW and MPV between patients and control .

Methods: This study was an analytic study with retrospective case control study design

Results: There are differences in level of hematocrit, NLR, PLR among patients with sudden sensorineural hearing loss and control in Sanglah hospital Denpasar (p<0.05, CI 95%)

Conclusion: There was a difference in hematocrit, NLR and PLR between patients with sudden deafness and control at Sanglah General Hospital, Denpasar.
Urban Growth Development Using Group Method of Data Handling
Authors: Evoh Obarijima Priscilla , Anireh Vincent Ike Emeka , Taylor Onate Egerton
Published: June 2022

Urbanization has significantly increased over the last two centuries. In year 1800 only 2% of people lived in cities, while in year 1900 this percent increased to 12%. Recent studies indicate that in year 2008 more than 50% of the world population lived in urban areas, with this percentage expected to reach 75% by year 2030. Urban land cover occupies only 2% or 3% of the earth surface, yet it has been recognized that urban growth is associated with many socioeconomic and environmental problems. For example, impervious surfaces that result from urbanization dramatically increase peak discharges associated with storm and snowmelt events, which in turn makes more likely downstream flooding as storm waters exceed stream channel capacities. Urbanization is a very important aspect in country’s development, that’s why this thesis presents urban growth development in Port Harcourt city. The thesis proposed a model in predicting the urban expansion in terms of population growth and land use expansion. The model was trained on a satellite imagery of greater Port Harcourt city. The satellite imagery covers Port Harcourt, Obio/Akpor, Eleme, Etchem, Oyibo, and Omumma local government area in Rivers state. The model was trained using group method of data handling. The result of the model shows a greater change in land use for grater Port Harcourt City, it also shows that by 2035, there will be an increase in pollution for about 5,449,213. The is to say that greater Port Harcourt city will have over 5 million population increase.
Strategic Performance Measurement System and Its Impact on Organizational Effectiveness: A Study of United Arab Emirates Based Organizations
Authors: Gupta Babeet , Agarwal Ruchi
Published: June 2022

Performance measurement has been subject to a considerable amount of research and attention over the past 15 years. The inadequacy of traditional financially based performance measurement systems and the introduction of nonfinancial measures have been the triggers for much of this research. The purpose of this paper is to review the performance measurement framework (Input-process-output), their application in the UAE based organizations in quality enhancement and to identify gaps in knowledge and practice that suggest future research. The paper draws on the study of performance indicators used in the 6 UAE based organizations. The design of indicators has been covered by many publications, but the design of measures specific and appropriate to UAE based organizations has not been well addressed. Based on the study of these organizations, a conceptual model is proposed that treats performance measurement as an integrated system, based on the TQM philosophy of continuous improvement cycles.
An Alternative Experimental Method for Determination of Light Beam Attenuation Coefficient in Underwater Wireless Optical Communication
Authors: Ponnle Akinlolu A. , Ojediran Oluwabukola A. , Oyetunji Samuel A.
Published: June 2022

In wireless optical communication systems, the transmission of optical signals via the channel (air or water) is affected by absorption and scattering. These reduce the signal strength (attenuation) and transmission distance of the signals. In pure water, the blue-green region of the visible light gives low attenuation. Some models have been developed to characterize the underwater optical channel such as Beer Lambert’s law, Radiative Transfer equation and Monte Carlo model. In underwater optical communication, optical power meters are an invaluable tool in the determination of attenuation coefficients. However, optical power meters for underwater optical communication are very expensive. There is a need to be able to determine the attenuation in the underwater optical communication channel at a low cost, especially in the absence of underwater optical power meters. In this paper, we present an alternative low-cost experimental method of obtaining the approximate attenuation coefficient of the visible light beam in underwater optical wireless communication without the use of optical power meters. A wireless visible light communication system was set up experimentally for underwater measurements involving an oscilloscope as the only measuring device. The system uses sub-carrier frequency modulation; a white light-emitting diode array for the transmitter, and a solar panel at the receiver front end. A theoretical transmission model was developed from the experimental setup based on the line of sight method in an unbounded medium, Beer Lambert’s law, and the received sub-carrier signals; in order to provide an alternative method of determining approximately the attenuation coefficient of the underwater medium. Experiments were performed in air, clear water and in saline water. The attenuation in the air was used as a reference upon which attenuation in the clear water and the saline water was based. The saline water has a salt concentration of 6.7 g/100 mL by weight and a total dissolved solid of 86.2 ppt. The trend of the measured received sub-carrier signals showed deviation from the developed theoretical model, and the model was therefore adjusted to conform to the experimental results. From the adjusted model, the attenuation coefficient of 0.0007379 cm-1 and 0.02447 cm-1 were obtained for clear water and the saline water respectively. The method is simple, straightforward, easy to set up in a laboratory, low cost and can be applied to visible light of any wavelength.
Effect of Chlorophyll in Garlic Chives (Allium tuberosum) Leaves by Drought and pH
Authors: Huh Man Kyu
Published: June 2022

Allium tuberosum Rotter (garlic chives) is a species of plant native to the Chinese province and naturalized elsewhere in Asia and around the world. In Korea, chives are boiled and used as seasoned vegetables or as soup ingredients, and are also used for chive kimchi and cucumber pickles. This paper describes experimental results for chlorophyll content and efficiency with drought stress and soil acidity on garlic chives. Analytical determination of total chlorophyll (a, b) was performed with spectrophotometer.  Chlorophyll fluorescence analysis was used to measure photosynthetic parameters with the Imaging-PAM Chlorophyll Fluorometer. The content of total chlorophyll was 0.711 at 80% moisture. The content for chlorophylls a, b, and total were 0.333, 0.151, and 0.390 at 10% moisture, respectively. The simple type of regression showed the relation between chlorophylls as a function of acidity. The slope factors for chlorophyll content (a, b, and total) were 0.866, 0.903, and 0.910, respectively. The current fluorescence yield (Ft) was increased to the decrease of water in soils. The maximal PSII quantum yield, Fv/Fm was the highest at 70% moisture among nine moisture percentage stages. The slope factors of Ft, Fm (maximum fluorescence yield), Fv (quenched state), and Fv/Fm for chlorophyll efficient indicators were -0.873, 0.977, 969, and 0.897, respectively. Water stress decreased chlorophyll a, chl b, chl (a + b) contents, and the chl a/b ratio in the A. tuberosum. Low soil pH also affected the chlorophyll content and efficiency of A. tuberosum.
The Hepatoprotective Effects of Ethanolic Extract Noni Fruits (Morinda citrifolia L.) on Rats (Rattus norvegicus) Liver with SGPT and Histopathological Evaluations
Authors: Kamri Andi Maulana , Rahmawati Rahmawati , Amirah Sitti
Published: June 2022

The liver is an important organ that plays a role in metabolism in the human body. However, the use of certain types of chemical compounds tends to damage these organs. This study aims to determine the hepatoprotective effectiveness of noni fruit (Morinda citrifolia L.) against exposure to hepatotoxic compounds. This research was conducted by experimental method with Groups I to III treated with noni extract with concentrations of 10, 15, and 20%, respectively. Group IV was treated with acetaminophen, a hepatotoxic substance, as a positive control and group V was treated with Na.CMC as a negative control. Data serum glutamate pyruvate transaminase (SGPT) levels and histopathological examination of the liver of the test animals were then analyzed by One-Way Anova. Histopathological examination results showed hepatotoxicity caused by high doses of acetaminophen 10 g/70 KgBW in the positive control group achieved a score of +4 (severe damage), groups I and II showed a score of +3 (moderate damage), and in group III only showed a score of +3 (moderate damage). +2 (light damage). The results of SGPT examination and histopathology showed that the ethanol extract of noni fruit at a concentration of 20% had a hepatoprotective effect.
¿ESTAREMOS NEGANDO NUESTRA HISTORIA NATURAL? RESULTADOS DE UNA ENCUESTA PARA LIMA METROPOLITANA, PERÚ
Authors: Aponte Héctor , Barona Daniel , Pazos Andrea , Ildefonso Diego , Mires Jannyna , Rios Luis , Thorne Daniela
Published: June 2022

Se evaluó la percepción de la población citadina de Lima sobre algunos aspectos relacionados con la evolución e historia natural del ser humano. Un total de 384 personas mayores de 18 años, fueron evaluadas por medio de una encuesta oral. Los resultados indican que un 34% de la población de Lima desconoce el pasado de nuestra especie de al menos unos 70000 años, así como la historia evolutiva de los homínidos, que tiene al menos unos 4 millones de años; el 48% no está de acuerdo con que nos hayamos desarrollado de otras especies animales; y el 32% considera que los seres humanos vivimos al mismo tiempo que los dinosaurios. Los resultados obtenidos deben ser utilizados para establecer políticas que permitan un acercamiento entre la población general y los científicos. Asimismo, estos resultados indican la necesidad de preparar a las nuevas generaciones con un pensamiento crítico apropiado, de manera que pueden tener una percepción adecuada del entorno y de la historia evolutiva de nuestra especie.