bluuebunny/crossref_metadata_2025 huggingface dataset:
Aspirin-NHS Ester Mediated Acetylation of Lysine Residues in β-Conglycinin: Implications for Cancer Research in NF-κB
Authors: Schlecht Syon , Gunderson Emily , Aguilar Takara
Published: February 2024

Post-translational modifications (PTMs) represent a dynamic and intricate layer of cellular regulation that significantly contributes to the diversification of protein functions (1). Among these modifications, lysine acetylation stands out as a crucial regulatory mechanism that modulates protein activities, subcellular localization, and interactions (2). This study focuses on expanding the role of lysine acetylation, a significant post-translational modification, within the nuclear factor-kappa B (NF-κB) transcription factor complex. NF-κB plays a crucial role in inflammation, immune responses, and cell survival, making it a pertinent target for cancer research (3). Dysregulation of NF-κB is implicated in various pathological conditions, emphasizing the need to explore lysine acetylation within this context. To perform the acetylation, we would attempt to use a common medication, Aspirin. Aspirin, or acetylsalicylic acid, is a widely studied non-steroidal anti-inflammatory drug (NSAID) that has been extensively used for its anti-inflammatory, analgesic, and antipyretic effects. In addition, the presence of an acetyl group on Aspirin results in a versatile molecule that can acetylate various proteins. (4). We synthesized Aspirin NHS ester (Aspirin-NHS) to capitalize on this versatility in acetylating biomolecules. This tailored approach allows for the selective targeting of lysine residues within proteins, offering a specific tool to examine the functional consequences of lysine acetylation within the NF-κB complex. For this study, a model protein system was used. We selected β-Conglycinin, a soy protein, that offers a pragmatic platform for investigating lysine acetylation within the NF-κB complex. β-Conglycinin is rich in lysine residues, similar to NF-κB, making it homologous to this line of inquiry (5). We can examine the theoretical considerations of lysine acetylation with practical experimental observations, providing a comprehensive understanding of the regulatory dynamics within the NF-κB complex. This research contributes not only to the expanding toolkit for precise protein acetylation modulation but also enhances our understanding of NF-κB's regulatory dynamics in the context of cancer, establishing a bridge between chemical synthesis and biological investigation.
Development of analytic gradients for the Huzinaga quantum embedding method and its applications to large-scale hybrid and double hybrid DFT forces
Authors: Csoka Jozsef , Hegely Bence , Nagy Peter , Kallay Mihaly
Published: February 2024

The theory of analytic gradients is presented for the projector-based density functional theory (DFT) embedding approach utilizing the Huzinaga-equation. The advantages of the Huzinaga-equation-based formulation are demonstrated. In particular, it is shown that the projector employed does not appear in the Lagrangian, and the potential risk of numerical problems is avoided at the evaluation of the gradients. The efficient implementation of the analytic gradient theory is presented for the approaches where hybrid DFT, second-order Moller-Plesset perturbation theory (MP2), or double hybrid DFT is embedded in lower-level DFT environments. To demonstrate the applicability of the method and to gain insight into its accuracy, it is applied to equilibrium geometry optimizations, transition state searches, and potential energy surface scans. Our results show that bond lengths and angles converge rapidly with the size of the embedded system. While providing structural parameters close to high-level quality for the embedded atoms, the embedding approach has the potential to relax the coordinates of the environment as well. Our demonstrations on a 171-atom zeolite and a 570-atom protein system show that the Huzinaga-equation-based embedding can accelerate (double) hybrid gradient computations by an order of magnitude with sufficient active regions and enables affordable force evaluations or geometry optimizations for molecules of hundreds of atoms.
EFFECT OF TACTICAL PLANNING ON THE PERFORMANCE OF MOBILE SERVICE PROVIDERS IN NIGERIA
Authors: Oli Frank Uzochukwu , Ibrahim Umar Abbas
Published: February 2024

Purpose: The research aimed to examine the impact of tactical planning on the performance of mobile service providers in Nigeria.
 
Theoretical Framework: The theoretical framework employed in this research is rooted in the Resource-Based View (RBV) Theory. RBV offers a comprehensive framework for understanding how operational planning influences the performance of mobile service providers by aligning internal resources with external market conditions and contributing to sustained competitive advantage.
 
Design/Methodology/Approach: Employing a survey research design, the study utilized a multistage sampling technique to gather primary data from a sample of 350 randomly chosen employees representing the workforce of the four major mobile network operators in Nigeria—MTN, Globacom, Airtel, and 9Mobile—comprising the study's target population.
 
Findings: The result of the regression analysis established a positive and statistically significant (p<0.05) relationship between tactical planning and business growth in Nigeria's mobile communication sector. Based on the findings of the study, it was concluded that tactical planning is a substantial contributor to business growth in the telecom sector in Nigeria.
 
Research, Practical & Social Implications: The study suggests that Nigerian mobile service providers should invest in refining their tactical planning processes, regularly assess their strategies, foster a culture of continuous improvement, engage in employee training, collaborate with industry peers, and stay updated with technological advancements. Companies should invest in comprehensive training programs and knowledge-sharing initiatives to build the strategic capabilities of their teams, ensuring a more effective implementation of tactical plans.
 
Originality/Value: The findings of this study are likely to have practical implications for mobile service providers, informing their tactical strategies and decision-making processes for improved performance and competitiveness in the Nigerian market.
Research on the Organization of the Innovation Consortium in the Aviation Industry: Taking the Development of Aviation Industry in Zhenjiang as an Example
Authors: Huang Xia , Hu Yongsheng , Zhou Liping
Published: February 2024

As a new type of organizational model, the aviation industry innovation consortium conforms to the inevitabletrend of industrial upgrading and scientific and technological innovation. Its core goal is to promote technologicalinnovation and upgrading of the aviation industry. This paper presents a comprehensive analysis of the development statusof the aviation industry in Zhenjiang and points out the problems and challenges it is currently facing. To solve theseproblems, we tackled the organizational model and implementation path of the aviation industry innovation consortiumand proposed targeted implementation measures aimed at promoting the development of Zhejiang’s aviation industry.
Research on Legal Protection of Minor Females from the Perspective of Soft Paternalism
Authors: Sun Yue
Published: February 2024

Soft paternalism involves limiting an individual’s freedom in situations where the person cannot make rationaldecisions, aiming to protect them from actions that may not align with their true intentions. Soft paternalism providesa foundation for the study of the criminal law protection of minor females in China. The inclusion of the crime ofsexual assault committed by individuals with caregiving responsibilities has brought about a transformation in China’sconventional single-age protection system for sexual crimes. This modification entails the categorization of the age ofprotection into three segments: absolute protection age, equal protection age, and relative protection age, thus establishinga comprehensive age protection system. Regardless of whether minor females between the ages of 14 and 16 consent,individuals with special responsibilities should be deemed to have committed this crime. It is essential to clearly define“special responsibilities” in this case.
A Study on Student Satisfaction and Continuance Intention Application Platform Based on Gamification
Authors: Chandrasari Agnes Monica Dwi , Nugraha Jaka
Published: February 2024

In this era, more and more advanced technology is available, and the technological developments that are made are very helpful to humans. The application of gamification is one of the results of technological advances, namely technological developments combined with the application of the concept of playing games into non-context games. This study aims to analyze the influence of satisfaction and continuance intention on students using gamification applications. This research is variance-based SEM with TAM and ECM models. GSCA application was used to analyze data with 83 respondents. The results of this research are that perceived usefulness has no effect on continuance intention, perceived ease of use influences satisfaction, perceived ease of use has an influence on gamification application value, gamification application value influences satisfaction, gamification application value influences continuance intention, satisfaction influences continuance intention.
Developing E-Modules for Correspondence Subject based on Project-Based Learning
Authors: Handayani Wuni , Wulandari Siti Sri
Published: February 2024

This study aims to develop E-Module teaching materials for Correspondence subjects based on Project Based Learning and analyze the feasibility of E-Modules for Correspondence subjects based on Project Based Learning.  This type of research is R&D which uses an adaptation of the 4D development model consisting of the defining stage (define), planning stage (design), and development stage (develop), but does not reach the dissemination stage. The results showed the acquisition of material expert validation scores of 86.81% classified as "Very Strong", language experts 90.55% classified as "Very Strong", and 81.11% of graphics experts classified as "Very Strong". The results of the students' response of 90.66% were classified as "Very Strong" and the teacher's response of 89.33% was classified as "Very Strong". Thus, this research, namely E-Modules for Correspondence subjects based on Project Based Learning, is suitable for use in learning and is expected to achieve the learning objectives that have been set.
The Effect of Self-Efficacy and Perception of Teacher Profession on Teaching Interest: Study on Bachelor Students of Office Administration Education
Authors: Annur Eka Wati , Trisnawati Novi
Published: February 2024

This research aims to determine the influence of self-efficacy on interest in becoming a teacher among students of the Office Administration Education Study Program, Surabaya State University, the influence of perceptions of the teaching profession on interest in becoming a teacher among students of the Office Administration Education Study Program, Surabaya State University, and the influence of self-efficacy and perceptions of the teacher profession towards students' interest in becoming teachers at the Office Administration Education Study Program, Surabaya State University. This research is included in the type of explanatory research with an associative quantitative approach. The population in this study was 2019 office administration education students totaling 52 respondents with a saturated sample. The data analysis technique in this research uses multiple linear regression which has previously been tested on classical assumptions with the help of the SPSS program. Based on the research results, namely: (1) There is a positive influence between self-efficacy on interest in becoming a teacher among students at the Office Administration Education Study Program, Surabaya State University. (2) There is a positive influence between the perception of the teaching profession on the interest in becoming a teacher among students at the Office Administration Education Study Program, Surabaya State University. (3) There is a positive influence between self-efficacy and perceptions of the teaching profession on interest in becoming a teacher among students at the Office Administration Education Study Program at Surabaya State University
Can Keyboarding Skills Improve Student Performance and Engagement?
Authors: Sholikah Mar'atus , Mubais Ahmad , Kurniawan Indra , Susanti Anis
Published: February 2024

Lecturers must strive for innovative and engaging learning so that students can feel involved in every learning process. Therefore, the student’s academic performance improved. This study tested the effectiveness of the blind system method assisted by 10-fast fingers learning media in improving students' performance and engagement. This study used a treatment-by-level design (T-LD). Seventy-three respondents were undergraduate students of business administration at Politeknik Balekambang Jepara. The data were collected through practicum tests and questionnaires. An independent sample test was used for data analysis. This study finds that 10-fast fingers learning media can improve students' cognitive and psychomotor performance. Thus, this medium is effective as a keyboard learning medium for improving student performance. The findings also found that 10-fast fingers media were able to increase student involvement in learning process activities. Therefore, this study concludes that the use of 10fastfingers media can improve academic performance and student engagement.
Implementation of E Office Applications at Universitas Negeri Malang (UM)
Authors: Anam Choirul
Published: February 2024

E-office refers to activities in the workplace that utilize electronic equipment and internet networks. At UM, e- office refers to a website-based application that is in the Sistem Informasi Akademik (Siakad). This paper intends to discuss the implementation of e-office applications in UM, the obstacles and challenges of implementation, as well as strategies for maximizing. The research method used is descriptive qualitative. Obtained data through observation, interviews, and literature studies. The results are the e-office at UM has a main function and a secondary function. The main function of the e-office is to write letters and send mail. The secondary function is media filing management, where users can search for certain letters by typing certain words in the Search menu. The obstacle is there are still many academicians, especially students who do not know the existence, even the function of e-office. The solution is socialization and workshops on the use of e-office applications. Maximization that can be done to improve the application in terms of correspondence is a variation of sentence templates and types of letters. The next optimization in filing management is the addition of the feature of scanning a document using a laptop camera, web camera, or cellphone, so the users can easily enter digital files into the e-office database. The second feature to improve records management is setting a record retention schedule.
Team-Based Project Implementation in Public Relations Learning Through PR Campaign Video Analysis
Authors: Susanti Anis , Oktarina Nina
Published: February 2024

This study aims to analyze the implementation of the Team-Based Project Learning method in Public Relations learning for Office Administration students of the Economics Faculty at Universitas Negeri Semarang. Some difficulties faced by office administration students in developing their skills become more complicated after the pandemic due to online learning. Online learning focuses more on lecturers than students, so it has not been able to solve the difficulties in developing their public relations skills. Team-Based Project Learning is implemented because it demands the ability of the students themselves to solve problems in working as public relations, while teachers as facilitators of ideas for problems that must be solved through PR-Campaign Video. This research uses a qualitative descriptive approach. Data analysis uses Milles and Huberman with data collection, data reduction, and conclusion. The data sources used are observations, interviews, and documentation. The results of this study showed that students who usually learn passively, produce active abilities in their groups because each of the students has a role in the groups to analyze the PR-Campaign video. Each group in team-based project learning has various ways of analyzing the project and has different creativity to present the results.
Strategies in Reading English Web-Novels on Wattpad
Authors: Nur Wulandari Ismi , Apriliaswati Rahayu , Sri Rezeki Yanti
Published: February 2024

Motivated by the popularity of online reading on Wattpad, this research was conducted to investigate the metacognitive awareness of digital and online reading strategies to 39 undergraduate students who read English Web-novels on Wattpad. Additionally, the researcher explored the potential influence of English proficiency (TOEFL) and field of study, as well as the specific features of Wattpad that aid in their reading experience. Employing a quantitative survey and adapting the Metacognitive Awareness of Reading Study Inventory (MARSI) developed by Mokhtari et al. (2018). The findings indicated that participants had a moderate level of strategies when reading English web-novels on Wattpad (M = 3.42). Problem Solving Reading Strategies were the most used (M = 3.80), followed by Global Reading Strategies (M = 3.73) and Support Reading Strategies (M = 2.73). English proficiency and field of study did not significantly impactful, with all groups showing similar levels (M = 3.4). Additionally, interactive features were not considered helpful (M = 2.51 and M = 2.23, respectively), while description and figure attachment features were frequently used (M = 4.15 and M = 3.25, respectively). The results indicated a necessity to integrate specific strategies, like incorporating Global Reading Strategies for pre-reading tasks and utilizing Problem Solving Strategies during reading activities, within EFL instruction. The research highlighted the obstacles encountered by both learners and instructors in the process of teaching and acquiring reading skills. It suggested that incorporating these strategies could effectively tackle comprehension challenges and improve overall language proficiency
МЕТОДИ ПРОЕКТУВАННЯ СИСТЕМИ ДОКУМЕНТООБІГУ УНІВЕРСИТЕТУ
Authors: Gorbachov V. , Yankovsky O. , Diyan V. , Balinskiy D.
Published: February 2024

Через постійне збільшення обсягів даних, які зберігаються та обробляються інформаційними системами, потрібне ретельне проектування архітектури систем, щоб уникнути зниження гнучкості та якості обробки даних. Метою даної роботи є проведення аналізу технологій розробки архітектури та програмного забезпечення паралельного розподіленого застосунку. Пропонується розробка та впровадження електронної системи документообігу в адміністративній системі вищого навчального закладу. У статті наведено аналітичне моделювання методом COMET системи документообігу вищого навчального закладу. Наукова новизна цього дослідження полягає в тому, що отримана модель дозволяє провести подальше математичне моделювання системи з метою оцінки параметрів реальної системи та визначення вузьких місць. Така модель представляє практичну цінність для подальших досліджень, розширення функціональності системи, а також для навчання нових співробітників вищого навчального закладу.
Penerapan Model Pembelajaran Guide Note Taking Pada Mata Pelajaran IPS untuk Meningkatkan Kualitas Proses dan Hasil Belajar Siswa Kelas IV SDN Tanjungtani 1 Kecamatan Prambon Kabupaten Nganjuk
Authors: Witri Witri
Published: February 2024

Pengamatan yang telah dilaksanakan di SDN Tanjungtani 1 Kecamatan Prambon  Kabupaten Nganjuk, dapat diketahui beberapa permasalahan yang timbul pada mata pelajaran IPS. Adapun rincian dari permasalahan yang timbul, antara lain: (1) nilai rata-rata siswa berdasarkan ulangan harian dan formatif mencapai 53,00 dengan prosentase ketuntasan belajar 33%. Nilai rata-rata tersebut masih di bawah Standar Ketuntasan Minimal (SKM) yang ditentukan oleh sekolah tersebut, yaitu 70,00 dengan prosentase ketuntasan belajar 80%; (2) guru diduga belum menggunakan model pembelajaran dalam proses pembelajaran; (3) siswa cenderung ramai dan jenuh dalam mengikuti proses pembelajaran. Adapun penelitian ini bertujuan untuk meningkatkan kompetensi yang dimiliki, dengan jalan meningkatkan kualitas proses dan hasil belajar siswa dengan menerapkan model pembelajaran Guided Note Taking.

Penelitian  ini menggunakan Penelitian Tindakan Kelas (PTK) dengan model Kemmis Taggart yang terdiri dari 3 siklus dan 4 tahapan, yaitu: tahap perencanaan, tahap pelaksanaan tindakan, tahap observasi, dan tahap refleksi. Subyek penelitian ini adalah siswa kelas IV SDN Tanjungtani 1 Kecamatan Prambon Kabupaten Nganjuk, yang terdiri dari 30 siswa dengan rincian 12 siswa laki-laki dan 18 siswa perempuan.

Penelitian ini menunjukkan adanya peningkatan kualitas proses dan hasil belajar siswa. Indikasi adanya dampak yang baik terhadap kualitas proses pembelajaran adalah dengan lebih baiknya guru dalam mengajar, yaitu guru dapat membuat RPP dengan model pembelajaran Guided Note Taking dan menerapkannya dalam proses pembelajaran. Hal tersebut berdampak terhadap meningkatnya kualitas proses belajar siswa yang semula siswa cenderung ramai dan jenuh dalam mengikuti proses pembelajaran, siswa menjadi lebih berkonsentrasi saat guru menerangkan, berani mengutarakan pendapat, berani menjawab pertanyaan guru, dan dapat bekerjasama dengan temannya saat proses pembelajaran berlangsung. Sedangkan untuk dampak terhadap peningkatan hasil belajar siswa adalah dengan adanya kenaikan rata-rata nilai, dari nilai siswa yang semula mencapai rata-rata 53,00 (sebelum diterapkan model pembelajaran Guided Note Taking), meningkat menjadi 63,00 pada siklus I, meningkat menjadi 67,11 pada siklus II, dan meningkat menjadi 72,34 pada siklus III. Selain itu dampak tersebut juga dapat dilihat dari prosentase ketuntasan belajar siswa, yaitu pada siklus I mencapai 73%, meningkat pada siklus II menjadi 83%, dan meningkat lagi pada siklus III menjadi 90%.
Resiliensi Guru Pada Masa Pandemi Covid-19
Authors: Erinasari Ruwita , Pradana Hengki Hendra , Fatria Nur Arqom Eka
Published: February 2024

Penelitian ini bertujuan untuk mengetahui resiiensi dari guru honorer pada saat pandemic covid-19. Penelitian ini menggunakan pendekatan kualitatig dengan jenis penelitian studi kasus. Pemilihan subjek penelitian dilakukan dengan teknik purposive sampling yaitu berjumlah dua subjek. Metode pengumpulan data dilakukan dengan cara wawancara. Hasil penelitian menunjukkan secara regulasi emosi dari kedua subjek masing-masing dapat mengontrol emosinya dengan baik. Pada pengendalian impuls, masing-masing subjek juga memberi pernyataan jika mereka dapat mengendalikan impuls dengan baik dan dapat menghargai orang lain dengan sebagaimana mestinya. Pada optimisme mereka menyatakan jika masing-masing subjek masih setengah-setengah untuk percaya terhadap dirinya sendiri. Pada Causal Analysis setiap subjek menyatakan bahwa dapat memecahkan masalahnya masing-masing. Selanjutnya pada empati, disini kedua subjek memiliki hubungan baik dengan orang disekitarnya. Sedang pada Self-Efficacy kedua subjek dapat menyelesaikan masalahnya secara baik. Terakhir pada Reaching Out kedua subjek merasa dalam masa pandemic ini pembelajaran dalam jaringan sangat membantu para guru untuk tetap melakukan tugasnnya dengan baik.
Hermeneutika al-Qur’an Nasr Hamid Abu Zaid: Suatu Pembacaan Hermeneutis Kritis
Authors: M. Abd. Rouf M. Abd. Rouf
Published: February 2024

As a way of life, religion—recitation on it through primary texts: the Qur'an and hadith—is always interesting to learn. Moreover, they are not only seen as a source of the truth but also as the axis of all religious activities. Therefore, define, read, and interpret them according to the needs of the times is an inevitability. Of course, recitation on it must be accompanied by scientific awareness of tradition in order to produce a current contextual understanding. This paper aims to examine the hermeneutics of al-Qur'an, based on Nasr Hamid Abu Zaid’s thought in masterpieces . Based on the comparative thought's method and critical analysis, concluded that learning religion—and the texts on it—requires an inclusive perspective, 1). Differentiation between religion and religious thought based on scientific awareness of tradition, 2). Viewing the Qur'an as a text in which various cultural variables are involved in its formation; 3). There are three semantis levels in producing meaning;  historical meaning, metaphorical meaning, and semantic inner meaning.
P145 Central Hemodynamic Response to Lower Body Negative Pressure in Individuals with Down Syndrome
Authors: Thessa I , Wee Sang Ouk , Grigoriadis Georgios , Schroeder Elizabeth , Baynard Tracy , Fernhall Bo
Published: February 2024

Introduction

Individuals with Down syndrome (DS) have autonomic dysfunction, which impacts heart rate and blood pressure regulation. Initial evidence also suggests an impaired ability to peripherally vasoconstrict during lower body negative pressure (LBNP). Given the relationship between vessel caliber and wave reflection, this may alter central hemodynamics and hemodynamic load. We aimed to investigate aortic hemodynamics and wave reflection during LBNP in individuals with DS and controls.

Methods

Radial applanation tonometry was performed on 15 individuals with DS (male n = 12, age 24 ± 1 yrs, BMI 29.4 ± 2.0 kg/m2) and 21 control participants (male n = 12, age 24 ± 1 yrs, BMI 24.4 ± 1.0 kg/m2) before, during and after a 5-min LBNP stimulus of –20 mmHg. Waveforms were calibrated to mean and diastolic brachial pressures. Generalized transfer function was used to estimate aortic pressures (systolic aSBP, diastolic aDBP and mean pressure aMAP), augmentation index (Aix), augmentation index normalized for HR (Aix@HR75), augmentation pressure (AP), reflection index (Rix) and forward (Pf) and reflected wave magnitude (Pb).

Results

Interaction effects were observed for AP, Aix, AIX@75, Rix and Pb (p < 0.05) in which DS had reductions in the outcome during LBNP whereas controls had little or no change. Although trending towards a larger drop in aSBP in individuals with DS, no significant interaction effects were found for aSBP, aDBP, aMAP, HR or Pf in response to LBNP.

Conclusion

These results show individuals with DS exhibited greater reductions in aortic pressure waveform characteristics and wave reflections in response to LBNP, indicative of reduced sympathetic control resulting in less peripheral vasoconstriction.
The effect of tobacco leave pastes (Nicotiana tabacum L.) 50% concentration as a denture cleanser on the surface roughness of thermoplastic nylon
Authors: Putri ADIRA NA  , Parnaadji RAHARDYAN  , Gunadi ACHMAD
Published: February 2024

Microporosity of thermoplastic nylon can lead to increased surface roughness values. Surface roughness of thermoplastic nylon can facilitate colonization of microorganisms that can lead to denture stomatitis. The mechanical cleaning process of denture using an electric toothbrush and denture cleaning paste is considered effective for removing plaque and microorganisms attached. To reduce surface roughness, the use of natural materials such as tobacco leaves is considered beneficial because it can reduce the content of abrasive materials. This study aims to determine the effect of tobacco leaf paste as a denture cleanser on the surface roughness of thermoplastic nylon. This study using a laboratory experimental design with a post test only control group design involving 27 samples sized 60 x 10 x 2.5 mm which were divided into three groups including the brushing control group without paste, the brushing group with placebo paste, and the brushing group with 50% tobacco leaf paste (TLP). The results showed that tobacco leaf paste was considered effective as a thermoplastic nylon denture cleanser and had an effect on reducing surface roughness values with an average surface roughness value that was still acceptable to the oral cavity. In conclusion, 50% tobacco leaf paste is recommended as an effective denture cleanser and produces surface roughness values acceptable to the oral cavity.
A rare case of bilateral antero-internal shoulder dislocation: A case study and review of the literature
Authors: Chrak Abdellah  , Arfaoui Hicham  , Baba Othmane  , Sbihi Yasser  , Oussama Eladaoui  , Fadili Mustapha
Published: February 2024

Introduction: Although anterior dislocations of the glenohumeral joint are the most frequent type of dislocation, bilateral forms are very rare [1] dominated by the posterior variant. We report a new case of bilateral anterior dislocation of the glenohumeral joints and discuss the mechanism and treatment. Case report: This concerns a 55-year-old patient, who presented to the emergency room with closed trauma to both shoulders in undetermined circumstances. The patient reported a disturbance of consciousness followed by a post-critical coma and generalized tonic-clonic seizures according to witnesses. Clinical examination revealed total functional impotence of the upper limbs, with the following findings: filling of the delto-pectoral groove, bilateral external axe strike, oedema of both shoulders. X-rays of both shoulders revealed bilateral anterior glenohumeral dislocation, with a nondisplaced fracture of the left great tuberosity. Discussion: Bilateral shoulder dislocation is a rare occurrence typically associated with specific etiologies such as epileptic seizures, electrical or neuromuscular disorders, or traumatic events. This report presents a case of bilateral shoulder dislocation in a patient with no history of ligament hyperlaxity, categorized under Brown's classification as traumatic origin. Despite the rarity of this presentation, similar unusual mechanisms of shoulder dislocation have been reported in the literature, including cases where each shoulder dislocated due to different mechanisms.
Current aspects of the pathogenesis and prevention of preeclampsia
Authors: Shkurenko Yu. V. , Ibatov A. D. , Trofimova S. Yu.
Published: February 2024

One of the most dangerous complications of pregnancy is preeclampsia. For effective prevention of preeclampsia, it is necessary to understand its mechanisms of development clearly. The analysis of modern patterns of preeclampsia cause and development are reviewed in this article. There are also the evidences of more effective strategies of prevention preeclampsia in our review, which have proven themselves most of all. The generalized endothelial mother’s disfunction is in the base of preeclampsia pathogenesis and caused by placental factors, genetical susceptibility and the lack of arterial invasion in trophoblast’s cell hereupon it increases the oxidative stress and inflammatory process, leading to complications of mother and fetus. More accurate understanding of preeclampsia mechanisms allows us to correct the adverse of lifestyle of patients and highlight those who are in the group of PE risk and need the prophylaxis to be prescribed. Nowadays, acetylsalicylic acid is a commonly accepted therapeutic medication and reliably effective (optimal dose from 75 to 162 mg). It is prescribed as the prevention from 11th to 14th week.
Vladimir Ivanovich Steklov (on his 60th birthday)
Authors: Editorial Article
Published: February 2024

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SISTEM INFORMASI MONITORING KEGIATAN ABSENSI SISWA DENGAN NOTIFIKASI WHATSAPP
Authors: Dedi Jubaedi Ahmad , Dwiyatno Saleh , Krisnaningsih Erni , Solihin  , Shafitri Adhe , Sutiawan Ade
Published: February 2024

This study focuses on Student Attendance Monitoring Information Systems with WhatsApp Notifications using the Waterfall method. Is a system designed to assist teachers and parents in monitoring student attendance effectively and in real-time. This system will send notifications via the WhatsApp application every time there is a lesson. Because there is still cheating or errors on the part of both students and teachers who are wrong in marking student attendance and the use of conventional attendance systems that are inefficient in terms of managing and controlling student attendance data. The Waterfall method was chosen because it is in accordance with a structured and gradual system development process. This method involves stages such as planning, analysis, design, implementation, and testing. In the planning stage will determine the needs and specifications of the system. The analysis phase will evaluate requirements and specifications to ensure that the system meets user requirements. The design phase will determine how the system will look and function. The implementation phase will execute the design and build the actual system. The testing phase will ensure that the system functions properly and meets specifications. From the results of the research, a Student Absenteeism Monitoring Information System with WhatsApp Notifications was created using the Waterfall method which can assist teachers and parents in monitoring student attendance effectively and in real-time. This system will simplify communication and make more informed and accurate decisions. This system can help in increasing student attendance, helping teachers and parents to work together in minimizing student absence.
Effectiveness Of Reminiscence Therapy And Brain Gym On Elderly’s Conitive Function
Authors: Gati Norman Wijaya , Hermawati  , Silvitasari Ika
Published: February 2024

Introduction: The Elderly is the last stage of human life development, a stage that experiences many changes and risk of experiencing illness due to the aging process. The aging process experienced by the elderly causes several changes, both changes in the physical aspect and changes in the psychological aspect. One of the changes experienced by the elderly is cognitive abilities. The cognitive abilities of the elderly are needed to help them live their lives productively. Conversely, if the elderly experience cognitive impairment, it will make the elderly experience obstacles in carrying out their daily activities. Objective: To determine the effectiveness of reminiscence therapy and brain gym on the cognitive function of the elderly. Methodology: This research used an experimental design with pre and post-tests using 2 intervention groups.  Brain gym reminiscence therapy was conducted in different groups, Result: Based on the test, the p-value of 0.632 is greater than 0.05, so it can be concluded that the cognitive level of the elderly with Reminiscence therapy is not better than the elderly who receive Brain Gym therapy. Conclusion: Brain gym therapy is proven to be more effective in dealing with cognitive impairment problems in the elderly compared to reminiscence therapy
El potencial del turismo cinegético en los cotos adehesados de Extremadura
Authors: Martín Delgado Luz María , Rengifo Gallego Juan Ignacio , Sánchez Martín José Manuel
Published: February 2024

La caza es una actividad muy extendida en Extremadura, que afecta a más del 80% de la superficie total regional. Esta práctica se ha convertido, en la actualidad, en una importante actividad productiva generadora de riqueza y empleo en zonas rurales, caracterizadas por la pérdida de población, el envejecimiento y la escasa diversificación económica. En el caso particular de Extremadura, gran parte de los terrenos cinegéticos se encuentran en la dehesa, un tipo de ecosistema único en el mundo del que se obtienen aprovechamientos agrícolas, ganaderos, forestales y cinegéticos. En estas zonas, el agroturismo se muestra como un complemento a la renta agraria. En este sentido, la caza es un recurso agroturístico del que se obtienen rentas. Por este motivo, en este artículo se ha analizado el potencial de las zonas de dehesa para el desarrollo del turismo cinegético mediante la aplicación de la geoestadística. Esta técnica ha permitido obtener resultados muy importantes, entre los que destacan: determinar aquellas zonas con mayor potencial para el desarrollo de este tipo de turismo, identificar diferentes grupos con características específicas en cuanto al predominio de especies cinegéticas, representar la presencia de lugares turísticos y restaurantes próximos a los cotos de caza y, por último, mostrar la presencia de atracciones turísticas en el área de estudio.
A Study on Music Teacher’s Perceptions of Piano Accompanying for Preservice Music Teacher
Authors:   The Korean Society of Music Education Technology, Ham Ina
Published: February 2024

This study investigates music teacher’s perceptions of the need, contents, and methods of piano accompanying education for preservice music teacher. The questionnaire was made based on the preceding research of piano accompanying and reviewed by three experts. A total 101 questionnaires were distributed out to music teachers and 85 were returned back. Numerical data were stored using SPSS software. Five more music teachers, not given questionnaire, and two piano accompanying instructors of university are interviewed for complement findings from questionnaire in depth. Findings reveal that high rate of those questioned perceives piano accompanying is one of the crucial education courses for preservice music teacher, though those questioned are not assured with the contents and methods of piano accompanying education. As a result, three suggestions are preposed. First, piano accompanying education needs to focus on practices and exercises during the courses. Second, piano accompanying and other music courses are needed to integrate in order to achieve the purpose of music education. Third, music teacher’s understanding towards piano accompanying needs to be changed.
An analysis of works of Ligeti that reflects Escher’s metamorphosis pattern
Authors:   The Korean Society of Music Education Technology, Kwag Hyungyu
Published: February 2024

Art, which was once dichotomized into space and time by G.E. Lessing (1729~1781), has expanded its temporal and spatial concept of 4D. As a result, it cannot be regulated to any specific area. Artistic works have expanded their area by means of temporal space or spatial time. For example, Escher attempted to express visualized time on the engraving, a spatial art. And, Ligeti attempted to express visualized space to temporal art, which is music art. Works of Escher and Ligeti have a common feature, which is co-existence of time and space in their work. In addition, they had structurally similar attitude in their awareness of peculiar characteristics, namely metamorphosis. Just as Escher did, Ligeti created metamorphosis patterns using clusters that caused auditory and cognitive response, and combined them into work in a complicated and combined way for juxtaposition and mix. In doing so, he created a double partition structure enabling to exchange front view and background. It has reflexive circulatory metamorphosis structure in which complicated polyphony part motives have metamorphosis connection and circulation. Accordingly, this study paid attention to the fact that artistic world and features of Escher are reflected into the works of Ligeti. And, the study attempted to have an opportunity to figure out virtual and real space and metamorphosis, which were pursuit by different methods in the areas of painting and music.
A study on the analysis and improvement of the music teacher training programs - Focused on metropolitan and provincial offices of education
Authors:   The Korean Society of Music Education Technology, PARK Jihyun
Published: February 2024

Recently, teacher training is more important factor in respect that emphasis is increasingly placed on autonomous application and various practice of curriculum in the field of education. The purpose of this study was on analyzing music teacher training programs for grasping the current situation of teacher training. For this objective, various literatures and materials were analyzed and examined: music teacher training programs of metropolitan and provincial offices of education in 2015, training schedules for teachers, and related legislation. Especially, this study focused on analyzing the aspects of types, subjects, contents, and methods of the training programs. As a result, the study suggested that the music teacher training program should 1) include teachers of special schools and operate harmoniously at school levels, 2) intensify more importantly experience-based activity than simplicity knowledge or contents, and 3) operate stably through the connection with related institutions for the music teacher training program such as schools, universities and music learning communities and research association.
The development of a teaching and learning model for the convergence education centered on music
Authors:   The Korean Society of Music Education Technology, Cho DaeHyun
Published: February 2024

The purpose of this research is to provide the theoretical and practical grounds for the convergence education that gets materialized with music being the center in the classes of the schools by proposing a teaching and learning model of the convergence education centered on music. For this, I, the researcher, first took a look at the concepts of the convergence and the convergence education of the STEAM education, which has been realized centered on science and the convergence education centered on music in the same context. And, furthermore, it was intended to state the need and the appropriateness of the convergence education centered on music with the present situation of the convergence education centered on music, the convergence personality of music, etc. Consequentially, together with the main conditions for the convergence education centered on music, the convergence model centered on the using a ’musical method’ and not a ’scientific method’ and its example were presented as the research results.
Effectiveness of Opera classes based on Multiple intelligences Theory : For Elementary School Students
Authors:   The Korean Society of Music Education Technology, Hwang Kyungsook
Published: February 2024

The purpose of this study is to evaluate the positive effectiveness of elementary school students’ Multiple Intelligence changes through the class designed for them to experience operas that is one of most condensed composite art forms based on the multiple intelligences (MI) theory of Howard Gardner. The class consisted with 7 lessons was conducted for 8 elementary school students over 7 weeks. To evaluate the effectiveness of opera class and experiences of participants, the MI test results profiles were analyzed before and after the class for the quantitive approach and participation observation, the transcribed personal interviews and document analysis were used for the qualitative approach. The results of the study showed that many participants became interested and confident in music and discovered their potential musical talent and they experienced increased confidence, empathy and cooperative attitude as positive changes of interpersonal intelligence and intrapersonal intelligence. And even there was a participant who discovered art talent in development of spatial intelligence. The study concluded that the designed classes in this study has provided to the students with the positive education experience through the artistic experience, which is the core concept of Gardner’s educational philosophy. It is expected that this study contributes to core competencies of 2015 education curriculum and suggests artistic educational experience as teaching, studying materials and encourages to develop more musical programs where MI theory are practically applied enhancing what is suggested in this study.
A Study on Teaching Competency Curriculum of Music in Arts & Culture Education Service
Authors:   The Korean Society of Music Education Technology, Chang EunUn
Published: February 2024

In the 21st century, as the nation-wide interests in the enjoyment of arts and culture have increased, Korean government has enacted the Arts and Culture Education Support Act and implemented the policies on arts and culture in various ways. The Arts and Culture Educator System is one of the Arts and Culture Education Support policies, which started in 2012 and still working. This paper examines the contents and chronological changes of the arts and culture educator system. Also, teaching competency curriculum of music in Arts & Culture Education Service will be focused. The curriculum of cultural arts educator System should be focused on raising capacity and quality of educators, so that they can take charge of arts and culture education in schools and societies as a whole. Teaching competency curriculum aims at equipping the trainees as artists and educators. This paper will examine Teaching Competency Curriculum of Music in Arts & Culture Education Service for the purpose of finding problems and suggesting solutions.
Analysis of Factors affecting the Competence of Choral Accompanist
Authors:   The Korean Society of Music Education Technology, Lee Sl
Published: February 2024

The purpose of this study was to identify the perceived factors affecting the competence of choral accompanists as a choral conductor and choral accompanist(n=65). The results of this study indicated that the musical communication skill with choral conductor, the preparation for choral rehearsals, the ability of playing piano with exact rhythm, the cooperative attitudes were the most influential factors affecting the competence of choral accompanists. Also, choral conductors and accompanists indicated that piano techniques to adjust tone color including the effect of orchestral sound for the choral works were the essential factors for choral accompanists. Other important factors affecting the competence of choral accompanists were the sight-reading skills and the ability that manages a panic situation during the performance. Recommendation and conclusion were provided for choral accompanists.
Optimasi Tablet Levofloksasin Immediate Release Menggunakan Disintegran Sodium Starch Glycolate (SSG) dan Pengisi Laktosa dengan Metode Simplex Lattice Design (SLD)
Authors: Shesanthi Citrariana  , Akhmad Kharis Nugroho  , Yahya Febrianto  , Defilia Anograh Riani
Published: February 2024

Levofloksasin adalah antibiotik yang digunakan dalam terapi utama infeksi paru, juga merupakan sediaan farmasi yang memiliki penerimaan yang baik oleh pasien. Tablet immediate release memerlukan super disintegran yang merupakan eksipien dalam formulasi, perbedaan eksipien yang digunakan dapat memengaruhi bioperformance dari tablet. Optimasi formula digunakan sebagai metode untuk menentukan komposisi eksipien dalam formula. Penelitian ini bertujuan untuk melakukan optimasi formula tablet levofloksasin dengan metode simplex lattice design menggunakan sodium starch glycolate sebagai superdisintegran. Pembuatan tablet dilakukan dengan proses granulasi basah dan dikempa kemudian dilakukan pengujian sifat fisik berupa kekerasan, kerapuhan, waktu hancur dan disolusi efisiensi pada waktu ke 60 menit. Optimasi nilai prediksi dilakukan dengan cara observasi dan dibandingkan nilai responnya menggunakan one sample t-test. Hasil penelitian menunjukan bahwa perbedaan nilai SSG terlihat signifikan pada waktu hancur dengan nilai p<0,05 (0,0056). Hasil formula optimal dengan nilai desirability 0,811 berada pada komposisi SSG sebanyak 8mg/tablet. Pengujian konfirmasi memberikan hasil bahwa antara nilai prediksi vs observasi memberikan nilai yang tidak berbeda p>0,05. Dapat disimpulkan bahwa tablet levofloksasin yang diformulasikan memberikan nilai yang memnuhi kriteria baik sifat fisik dan efisiensi disolusi.