bluuebunny/crossref_metadata_2025 huggingface dataset:
Transposable element-initiated enhancer-like elements generate the subgenome-biased spike specificity of polyploid wheat
Authors: Xie Yilin , Ying Songbei , Li Zijuan , Zhang Yu’e , Zhu Jiafu , Zhang Jinyu , Wang Meiyue , Diao Huishan , Wang Haoyu , Zhang Yuyun , Ye Luhuan , Zhuang Yili , Zhao Fei , Teng Wan , Zhang Wenli , Tong Yiping , Cho Jungnam , Dong Zhicheng , Xue Yongbiao , Zhang Yijing
Published: November 2023

Transposable elements (TEs) comprise ~85% of the common wheat genome, which are highly diverse among subgenomes, possibly contribute to polyploid plasticity, but the causality is only assumed. Here, by integrating data from gene expression cap analysis and epigenome profiling via hidden Markov model in common wheat, we detect a large proportion of enhancer-like elements (ELEs) derived from TEs producing nascent noncoding transcripts, namely ELE-RNAs, which are well indicative of the regulatory activity of ELEs. Quantifying ELE-RNA transcriptome across typical developmental stages reveals that TE-initiated ELE-RNAs are mainly from RLG_famc7.3 specifically expanded in subgenome A. Acquisition of spike-specific transcription factor binding likely confers spike-specific expression of RLG_famc7.3-initiated ELE-RNAs. Knockdown of RLG_famc7.3-initiated ELE-RNAs resulted in global downregulation of spike-specific genes and abnormal spike development. These findings link TE expansion to regulatory specificity and polyploid developmental plasticity, highlighting the functional impact of TE-driven regulatory innovation on polyploid evolution.
Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations
Authors: Zhao Shujuan , Mekbib Kedous Y. , van der Ent Martijn A. , Allington Garrett , Prendergast Andrew , Chau Jocelyn E. , Smith Hannah , Shohfi John , Ocken Jack , Duran Daniel , Furey Charuta G. , Hao Le Thi , Duy Phan Q. , Reeves Benjamin C. , Zhang Junhui , Nelson-Williams Carol , Chen Di , Li Boyang , Nottoli Timothy , Bai Suxia , Rolle Myron , Zeng Xue , Dong Weilai , Fu Po-Ying , Wang Yung-Chun , Mane Shrikant , Piwowarczyk Paulina , Fehnel Katie Pricola , See Alfred Pokmeng , Iskandar Bermans J. , Aagaard-Kienitz Beverly , Moyer Quentin J. , Dennis Evan , Kiziltug Emre , Kundishora Adam J. , DeSpenza Tyrone , Greenberg Ana B. W. , Kidanemariam Seblewengel M. , Hale Andrew T. , Johnston James M. , Jackson Eric M. , Storm Phillip B. , Lang Shih-Shan , Butler William E. , Carter Bob S. , Chapman Paul , Stapleton Christopher J. , Patel Aman B. , Rodesch Georges , Smajda Stanislas , Berenstein Alejandro , Barak Tanyeri , Erson-Omay E. Zeynep , Zhao Hongyu , Moreno-De-Luca Andres , Proctor Mark R. , Smith Edward R. , Orbach Darren B. , Alper Seth L. , Nicoli Stefania , Boggon Titus J. , Lifton Richard P. , Gunel Murat , King Philip D. , Jin Sheng Chih , Kahle Kristopher T.
Published: November 2023

To elucidate the pathogenesis of vein of Galen malformations (VOGMs), the most common and most severe of congenital brain arteriovenous malformations, we performed an integrated analysis of 310 VOGM proband-family exomes and 336,326 human cerebrovasculature single-cell transcriptomes. We found the Ras suppressor p120 RasGAP (RASA1) harbored a genome-wide significant burden of loss-of-function de novo variants (2042.5-fold, p = 4.79 x 10−7). Rare, damaging transmitted variants were enriched in Ephrin receptor-B4 (EPHB4) (17.5-fold, p = 1.22 x 10−5), which cooperates with p120 RasGAP to regulate vascular development. Additional probands had damaging variants in ACVRL1, NOTCH1, ITGB1, and PTPN11. ACVRL1 variants were also identified in a multi-generational VOGM pedigree. Integrative genomic analysis defined developing endothelial cells as a likely spatio-temporal locus of VOGM pathophysiology. Mice expressing a VOGM-specific EPHB4 kinase-domain missense variant (Phe867Leu) exhibited disrupted developmental angiogenesis and impaired hierarchical development of arterial-capillary-venous networks, but only in the presence of a “second-hit” allele. These results illuminate human arterio-venous development and VOGM pathobiology and have implications for patients and their families.
The metabolic, virulence and antimicrobial resistance profiles of colonising Streptococcus pneumoniae shift after PCV13 introduction in urban Malawi
Authors: Obolski Uri , Swarthout Todd D. , Kalizang’oma Akuzike , Mwalukomo Thandie S. , Chan Jia Mun , Weight Caroline M. , Brown Comfort , Cave Rory , Cornick Jen , Kamng’ona Arox Wadson , Msefula Jacquline , Ercoli Giuseppe , Brown Jeremy S. , Lourenço José , Maiden Martin C. , French Neil , Gupta Sunetra , Heyderman Robert S.
Published: November 2023

Streptococcus pneumoniae causes substantial mortality among children under 5-years-old worldwide. Polysaccharide conjugate vaccines (PCVs) are highly effective at reducing vaccine serotype disease, but emergence of non-vaccine serotypes and persistent nasopharyngeal carriage threaten this success. We investigated the hypothesis that following vaccine, adapted pneumococcal genotypes emerge with the potential for vaccine escape. We genome sequenced 2804 penumococcal isolates, collected 4-8 years after introduction of PCV13 in Blantyre, Malawi. We developed a pipeline to cluster the pneumococcal population based on metabolic core genes into “Metabolic genotypes” (MTs). We show that S. pneumoniae population genetics are characterised by emergence of MTs with distinct virulence and antimicrobial resistance (AMR) profiles. Preliminary in vitro and murine experiments revealed that representative isolates from emerging MTs differed in growth, haemolytic, epithelial infection, and murine colonisation characteristics. Our results suggest that in the context of PCV13 introduction, pneumococcal population dynamics had shifted, a phenomenon that could further undermine vaccine control and promote spread of AMR.
Time, momentum, and energy resolved pump-probe tunneling spectroscopy of two-dimensional electron systems
Authors: Yoo H. M. , Korkusinski M. , Miravet D. , Baldwin K. W. , West K. , Pfeiffer L. , Hawrylak P. , Ashoori R. C.
Published: November 2023

Real-time probing of electrons can uncover intricate relaxation mechanisms and many-body interactions in strongly correlated materials. Here, we introduce time, momentum, and energy resolved pump-probe tunneling spectroscopy (Tr-MERTS). The method allows the injection of electrons at a particular energy and observation of their subsequent decay in energy-momentum space. Using Tr-MERTS, we visualize electronic decay processes, with lifetimes from tens of nanoseconds to tens of microseconds, in Landau levels formed in a GaAs quantum well. Although most observed features agree with simple energy-relaxation, we discovered a splitting in the nonequilibrium energy spectrum in the vicinity of a ferromagnetic state. An exact diagonalization study suggests that the splitting arises from a maximally spin-polarized state with higher energy than a conventional equilibrium skyrmion. Furthermore, we observe time-dependent relaxation of the splitting, which we attribute to single-flipped spins forming skyrmions. These results establish Tr-MERTS as a powerful tool for studying the properties of a 2DES beyond equilibrium.
The seafloor from a trait perspective. A comprehensive life history dataset of soft sediment macrozoobenthos
Authors: Meijer Kasper J. , Gusmao Joao Bosco , Bruil Lisa , Franken Oscar , Grimm Ise A. , van der Heide Tjisse , Hijner Nadia , Holthuijsen Sander J. , Hübner Lisa , Thieltges David W. , Olff Han , Eriksson Britas Klemens , Govers Laura L.
Published: November 2023

Biological trait analysis (BTA) is a valuable tool for evaluating changes in community diversity and its link to ecosystem processes as well as environmental and anthropogenic perturbations. Trait-based analytical techniques like BTA rely on standardised datasets of species traits. However, there are currently only a limited number of datasets available for marine macrobenthos that contain trait data across multiple taxonomic groups. Here, we present an open-access dataset of 16 traits for 235 macrozoobenthic species recorded throughout multiple sampling campaigns of the Dutch Wadden Sea; a dynamic soft bottom system where humans have long played a substantial role in shaping the coastal environment. The trait categories included in this dataset cover a variety of life history strategies that are tightly linked to ecosystem functioning and the resilience of communities to (anthropogenic) perturbations and can advance our understanding of environmental changes and human impacts on the functioning of soft bottom systems.
Clinical efficacy of electroacupuncture-like magnetic therapy compared to conventional transcutaneous electrical nerve stimulation in individuals with carpal tunnel syndrome
Authors: Lo Sui-Foon , Chou Li-Wei , Chung Huynh , Lin Hsiu-Chen
Published: November 2023

This study aimed to evaluate the clinical efficacy of an electroacupuncture-like magnetic therapy (ELMT) and conventional transcutaneous electrical nerve stimulation (TENS) in patients with carpal tunnel syndrome (CTS). A prospective randomized controlled trial in single-centre was conducted. Thirty-four CTS patients confirmed by electrodiagnostic study were randomized into TENS or ELMT group and completed a six-week treatment program. TENS or ELMT treatment was applied on acupuncture point PC-6 (Neiguan) and one selected hand acupoint. Therapeutic exercises were also included after the electrophysical modality. Their physical signs, motor and sensory performances, Boston Carpal Tunnel Questionnaire (BCTQ) scores, and results of electrodiagnostic study were evaluated. After treatments, both groups demonstrated significantly decreased BCTQ scores and positive rate of Tinel’s sign in the major symptomatic side, which indicated improvements in the symptom severity and physical functions. Significant increases in distal sensory amplitude and nerve conduction velocity of the median nerve were only found in the ELMT group. Our study found either conventional TENS or ELMT plus therapeutic exercises could improve the symptomatology and physical provocation sign of CTS. The ELMT has additional improvement in the nerve conduction in patients with CTS.
Interactions between functional networks in Parkinson's disease mild cognitive impairment
Authors: Delgado-Alvarado Manuel , Ferrer-Gallardo Vicente J. , Paz-Alonso Pedro M. , Caballero-Gaudes César , Rodríguez-Oroz María C.
Published: November 2023

The study of mild cognitive impairment (MCI) is critical to understand the underlying processes of cognitive decline in Parkinson’s disease (PD). Functional connectivity (FC) disruptions in PD-MCI patients have been observed in several networks. However, the functional and cognitive changes associated with the disruptions observed in these networks are still unclear. Using a data-driven methodology based on independent component analysis, we examined differences in FC RSNs among PD-MCI, PD cognitively normal patients (PD-CN) and healthy controls (HC) and studied their associations with cognitive and motor variables. A significant difference was found between PD-MCI vs PD-CN and HC in a FC-trait comprising sensorimotor (SMN), dorsal attention (DAN), ventral attention (VAN) and frontoparietal (FPN) networks. This FC-trait was associated with working memory, memory and the UPDRS motor scale. SMN involvement in verbal memory recall may be related with the FC-trait correlation with memory deficits. Meanwhile, working memory impairment may be reflected in the DAN, VAN and FPN interconnectivity disruptions with the SMN. Furthermore, interactions between the SMN and the DAN, VAN and FPN network reflect the intertwined decline of motor and cognitive abilities in PD-MCI. Our findings suggest that the memory impairments observed in PD-MCI are associated with reduced FC within the SMN and between SMN and attention networks.
Noise analysis of Grover and phase estimation algorithms implemented as quantum singular value transformations for a small number of noisy qubits
Authors: Ijaz Muhammad Abdullah , Faryad Muhammad
Published: November 2023

The quantum singular value transformation (QSVT) algorithm is a general framework to implement most of the known algorithms and provides a way forward for designing new algorithms. In the present work, the impact of noise on the QSVT algorithm is examined for bit flip, phase flip, bit-phase flip, and depolarizing noise models for a small number of qubits. The small number of noisy qubits approximates the currently available noisy quantum computers. For simulation results, the QSVT implementation of the Grover search and quantum phase estimation (QPE) algorithms is considered. These algorithms are among the basic quantum algorithms and form the building blocks of various applications of quantum algorithms. The results showed that the QSVT implementation of the Grover search and QPE algorithms has a consistently worse dependence upon noise than the original implementation for all four noise models. The probability of success of the Grover algorithm and phase measured by the QPE algorithm were found to exponentially depend upon the error probability in the noisy channels but only linearly dependent on the number of qubits.
An open-label study evaluating the safety and efficacy of budesonide in patients with IgA nephropathy at high risk of progression
Authors: Obrișcă Bogdan , Vornicu Alexandra , Mocanu Valentin , Dimofte George , Andronesi Andreea , Bobeică Raluca , Jurubiță Roxana , Sorohan Bogdan , Caceaune Nicu , Ismail Gener
Published: November 2023

We sought to evaluate the efficacy and safety of budesonide (Budenofalk) in the treatment of patients with IgA Nephropathy. We conducted a prospective, interventional, open-label, single-arm, non-randomized study that enrolled 32 patients with IgAN at high risk of progression (BUDIGAN study, ISRCTN47722295, date of registration 14/02/2020). Patients were treated with Budesonide at a dose of 9 mg/day for 12 months, subsequently tapered to 3 mg/day for another 12 months. The primary endpoints were change of eGFR and proteinuria at 12, 24 and 36 months. The study cohort had a mean eGFR and 24-h proteinuria of 59 ± 24 ml/min/1.73m2 and 1.89 ± 1.5 g/day, respectively. Treatment with budesonide determined a reduction in proteinuria at 12-, 24- and 36-months by -32.9% (95% CI − 53.6 to − 12.2), − 49.7% (95% CI − 70.1 to − 29.4) and − 68.1% (95% CI − 80.6 to − 55.7). Budesonide determined an eGFR preservation corresponding to a 12-, 24- and 36-months change of + 7.68% (95% CI − 4.7 to 20.1), + 7.42% (95% CI − 7.23 to 22.1) and + 4.74% (95%CI − 13.5 to 23), respectively. The overall eGFR change/year was + 0.83 ml/min/y (95% CI − 0.54 to 4.46). Budesonide was well-tolerated, and treatment emergent adverse events were mostly mild in severity and reversible. Budesonide was effective in the treatment of patients with IgAN at high-risk of progression in terms of reducing proteinuria and preserving renal function over 36 months of therapy.
Modeling phenotypic heterogeneity towards evolutionarily inspired osteosarcoma therapy
Authors: Welch Darcy L. , Fridley Brooke L. , Cen Ling , Teer Jamie K. , Yoder Sean J. , Pettersson Fredrik , Xu Liping , Cheng Chia-Ho , Zhang Yonghong , Alexandrow Mark G. , Xiang Shengyan , Robertson-Tessi Mark , Brown Joel S. , Metts Jonathan , Brohl Andrew S. , Reed Damon R.
Published: November 2023

Osteosarcoma is the most common bone sarcoma in children and young adults. While universally delivered, chemotherapy only benefits roughly half of patients with localized disease. Increasingly, intratumoral heterogeneity is recognized as a source of therapeutic resistance. In this study, we develop and evaluate an in vitro model of osteosarcoma heterogeneity based on phenotype and genotype. Cancer cell populations vary in their environment-specific growth rates and in their sensitivity to chemotherapy. We present the genotypic and phenotypic characterization of an osteosarcoma cell line panel with a focus on co-cultures of the most phenotypically divergent cell lines, 143B and SAOS2. Modest environmental (pH, glutamine) or chemical perturbations dramatically shift the success and composition of cell lines. We demonstrate that in nutrient rich culture conditions 143B outcompetes SAOS2. But, under nutrient deprivation or conventional chemotherapy, SAOS2 growth can be favored in spheroids. Importantly, when the simplest heterogeneity state is evaluated, a two-cell line coculture, perturbations that affect the faster growing cell line have only a modest effect on final spheroid size. Thus the only evaluated therapies to eliminate the spheroids were by switching therapies from a first strike to a second strike. This extensively characterized, widely available system, can be modeled and scaled to allow for improved strategies to anticipate resistance in osteosarcoma due to heterogeneity.
Comparative study of rainfall prediction based on different decomposition methods of VMD
Authors: Zhang Xianqi , Yin Qiuwen , Liu Fang , Li Haiyang , Qi Yu
Published: November 2023

Rainfall forecasting is an important means for macro-control of water resources and prevention of future disasters. In order to achieve a more accurate prediction effect, this paper analyzes the applicability of the "full decomposition" and "stepwise decomposition" of the VMD (Variational mode decomposition) algorithm to the actual prediction service; The MAVOA (Modified African Vultures Optimization Algorithm) improved by Tent chaotic mapping is selected; and the DNC (Differentiable Neural Computer), which combines the advantages of recurrent neural networks and computational processing, is applied to the forecasting. The different VMD decompositions of the MAVOA-DNC combination together with other comparative models are applied to example predictions at four sites in the Huaihe River Basin. The results show that SMFSD (Single-model Fully stepwise decomposition) is the most effective, and the average Root Mean Square Error (RMSE) of the forecasts for the four sites of SMFSD-MAVOA-DNC is 9.02, the average Mean Absolute Error (MAE) of 7.13, and the average Nash-Sutcliffe Efficiency (NSE) of 0.94. Compared with the traditional VMD full decomposition, the RMSE is reduced by 7.42, the MAE is reduced by 4.83, and the NSE is increased by 0.05; the best forecasting results are obtained compared with other coupled models.
Analysis of factors associated with the use of Korean medicine after spinal surgery using a nationwide database in Korea
Authors: Kim Doori , Lee Yoon Jae , Jang Bo-Hyoung , Park Jeong-Su , Park Sunju , D’Adamo Christopher R. , Shin Yong Cheol , Ko Seong-Gyu
Published: November 2023

Many patients in Korea use Korean Medicine (KM) after spine surgery, but related research is lacking. Therefore, this retrospective cohort study aimed to analyze factors affecting the use and costs of KM using nationally representative data from the National Health Insurance Service-National Sample Cohort, South Korea. Patients who underwent spinal surgery for spinal diseases from 2011 to 2014 were followed up for 5 years, and their medical care was described. The association between patient and spinal surgery characteristics and the use of KM was analyzed. A two-part model was used to analyze factors affecting the use of KM in patients undergoing spinal surgery. Of 11,802 patients who underwent spinal surgery, 11,367 who met the inclusion criteria were included. Overall, 55.5% were female, 32.3% were aged ≥ 70 years, and 50.2% received KM treatment during the follow-up period. Open discectomy was the most common surgical procedure performed (58.6%), and 40.2% of surgeries were performed because of lumbar disc disorder. Female sex, older age, high Charlson Comorbidity Index score, and use of KM before surgery were associated with increased KM use and expenditure after surgery. In conclusion, patient characteristics, rather than surgical characteristics, appeared to be more strongly associated with the use of KM after surgery, particularly prior experience with KM use. This study is significant in that it analyzed the entire spine surgery to provide a comprehensive view of the use of KM after spine surgery and analyzed the impact of various factors related patients and surgical characteristics on KM use. The results of this study may be useful to patients with spinal diseases, clinicians, and policymakers.
Strategy for Synthesizing Carbon Dots by Artificial Intelligence
Authors: Liu Hui , Zhou Jun , Huang Cheng Zhi
Published: November 2023

Artificial intelligence analyzes data to find out the laws hidden behind the data. The decisive factors for carbon dots (CDs) synthesis can be screened out using artificial intelligence, enabling chemists to quickly and reliably obtain the optimal reaction parameters to synthesize the desired CDs. Compared with traditional synthetic methods, a lot of synthesis time and resources can be saved. Moreover, artificial intelligence technology is expected to be used in the study of CD mechanisms. Since there are many factors that affect the luminescence of CDs, and the structure of CDs is relatively complex, machine learning will automatically analyze the most essential characteristics from many factors. This will help people understand the luminescent mechanism and application of CDs more easily.
Functionalization of Carbon Dots and Their Catalytic Applications
Authors: Liu Meng Li , Chen Bin Bin , Huang Cheng Zhi
Published: November 2023

Carbon dots (CDs), a new type of luminescent zero-dimensional carbon nanomaterial, have been used in a wide range of applications. The functionalization of CDs including heteroatom doping and surface modification is a very useful method for effectively tuning their intrinsic structure and surface state. Heteroatom doping in CDs can be used to tune their intrinsic properties, and has received significant research interest because of its simplicity. Surface modification can be used to change the active sites and functional groups on the surface of CDs, endowing the CDs with unique properties due to functional ligands. Because of their good conductivity and rapid electron transfer properties, CDs can be used as highly efficient catalysts in various catalytical applications, including photocatalysis, peroxidase-like catalysis, electrocatalysis, Fenton-like catalysis, and chemical catalysis. This chapter is intended to assist researchers in understanding the impact of functionalization on the intrinsic structure and optical properties of CDs, to provide useful information on methods for controlling CDs’ properties, as well as to introduce excellent catalytical applications of CDs.
Applications of Carbon Dots in Ion Sensing
Authors: Lu Siyu
Published: November 2023

At present, different synthesis methods have been developed for the fabrication of pure or doped CDs with different structures and properties, which promotes the constant optimization of analysis performance. However, the fluorescence mechanism of CDs has not been completely solved, which hinders its further application in ion detection; more theoretical and experimental work, and a combination of the two, is needed. For the analysis of ions based on CDs, we believe that it will be exciting if CDs with novel surface modification are used to probe other ions that have not been reported, which will be helpful for biological processes and exploiting solar energy etc. Moreover, it is an ultimate goal that CD-based sensors can be constructed efficiently for the rapid, exact, sensitive and selective sensing of ions, which can be applied in situ in the real environment with satisfactory results and be further commercialized. Finally, we are also optimistic about the development of CDs in other fields, for example, cancer therapy, bioimaging, electrocatalysis, and photocatalysis, etc.
Exciting Prospects for Green Development of Photoluminescent Carbon Dots
Authors: Liu Meng Li , Chen Bin Bin , Huang Cheng Zhi
Published: November 2023

This chapter describes the advantages of carbon dots (CDs) compared to other traditional luminescent materials such as quantum dots and organic dyes. Furthermore, the issues and challenges faced by the CDs are discussed in detail. Lastly, we have focused on the exciting future prospects for green development of CDs.
Greener Solutions to Achieve Durable Water Repellency Without Using PFASs
Authors: Cook E. K. , Brown-Augustine M. , Creel E. , Raj S.
Published: November 2023

This chapter explores achieving durable water repellent (DWR) coatings on textiles without the use of perfluoroalkyl and polyfluoroalkyl substances (PFASs). This was a challenge posed by W. L. Gore and Associates to the Greener Solutions Course project team at the University of California (UC) Berkeley. Ideally, a non-PFAS DWR coating would be highly hydrophobic to achieve dynamic water repellency; exhibit oil-repelling (oleophobic) properties for self-cleaning and insulation; and be durable, washable, and aesthetically pleasing to consumers. Inspiration for non-fluorinated, bio-inspired solutions was drawn from the natural hydrophobic mechanism of micro- and nano-hierarchical structuring of the lotus leaf as well as other organisms. The project team performed a literature review specific for hierarchical structuring using low hazard fibers and solvents, resulting in numerous potential alternatives. The two most promising solutions were silica nanosols and blow spinning, which showed the best hydrophobicity, potential for oleophobicity, and applicability to textiles. This chapter also highlights the mechanics of water- and oil-repellency of the possible DWR alternatives, potential hazards, and recommendations made by the project team based on these findings.
Tracking nitrite's deviation from Stokes–Einstein predictions with pulsed field gradient 15N NMR spectroscopy
Authors: Graham Trent R. , Wei Yihui , Walter Eric D. , Nienhuis Emily T. , Chun Jaehun , Schenter Gregory K. , Rosso Kevin M. , Pearce Carolyn I. , Clark Aurora E.
Published: November 2023

The diffusivities of nitrite in concentrated sodium nitrite and simulant radioactive waste observed with 15N PFGSTE-NMR spectroscopy exceeded predictions based on the Stokes–Einstein relationship.
Redox-active ligand promoted electrophile addition at cobalt
Authors: Zou Minzhu , Waldie Kate M.
Published: November 2023

A cobalt–phenylenediamide complex reacts with electrophilic CF3+ and F+ sources, generating new Co(iii)–CF3 or Co(iii)–F species through ligand-to-substrate two-electron transfer.
Synthesis, structure, and investigation of unique magnetic properties in two novel Mn-based coordination polymers
Authors: Li Duqingcuo , Liu Yichen , Xiang Ruifang , Li Yuyan , Qin Tianrui , Dong Xiu Yan , Sakiyama Hiroshi , Muddassir Mohd. , Liu Jianqiang
Published: November 2023

Two new manganese(ii) coordination polymers (CPs) 1 and 2 were synthesized. Their magnetic properties have been studied, showing complicated cryomagnetic behavior, suggesting the temperature-induced structural change.
FeS2and WO3nanoparticles decorated on biochar as a high throughput electrode for supercapacitors
Authors: Waris  , Abdulaziz Fahad , Latif Salman , Alanazi Abdulaziz , Khan Mohammad Zain
Published: November 2023

The need for cutting-edge energy storage technologies, such as supercapacitors, has been enhanced tremendously to meet the demands of the growing population and depleting fossil fuel reserves.
Metal–organic frameworks for next-generation energy storage devices; a systematic review
Authors: Sandhu Zeshan Ali , Raza Muhammad Asam , Awwad Nasser S. , Ibrahium Hala A. , Farwa Umme , Ashraf Sawera , Dildar Arooj , Fatima Eman , Ashraf Sufyan , Ali Furqan
Published: November 2023

The future of renewable energy and sustainable transportation depends on advanced energy storage technologies.
Tuning the fluorescence sensing for Fe3+ ions by using different dipyridyl linkers in pillar-layered metal–organic frameworks
Authors: Liu Yan-E , Zhou Ye , Li Xiao-Yu , Yao Jun , Li Qiu-Xia , Xu Quan-Qing , Zhu Rong-Rong , Zhu Ai-Xin
Published: November 2023

This study reveals that different dipyridyl linkers influence the fluorescence sensing for Fe3+ ions in pillar-layered MOFs.
Micelle assisted synthesis of bismuth oxide nanoparticles for improved chemocatalytic degradation of toxic Congo red into non-toxic products
Authors: Pious Aleena , Muthukumar Shreya , Singaravelu Dharshini Karnan , Nantheeswaran Periyappan , Mariappan Mariappan , Sivasubramanian Arvind , Ameen Fuad , Gancarz Marek , Veerappan Anbazhagan
Published: November 2023

Bi2O3 NPs catalyze congo red decolourization and make it non-toxic.
Simple devising of N-doped carbon dots (N-CDs) as a low-cost probe for selective environmental toxin detection and security applications
Authors: Annamalai Kumaresan , Annamalai Arun , Ravichandran Ramya , Jeevarathinam Anandhavalli , Annamalai Padmanaban , Valdes Hector , Elumalai Sundaravadivel
Published: November 2023

N doped CDs prepared from simple precursors for multipotential applications such as visual detection probe and security applications.
Gold catalysed regio- and chemoselective azo coupling of 1,2- and 1,4-diazoquinones with 1H-indoles
Authors: Jin Jianwen , León Rojas Andrés Felipe , Zhao Yichao , Helen Kyne Sara , Xia Bo , Zhong Bingwei , Chan Philip Wai Hong
Published: November 2023

A synthetic method that enables the regio- and chemoselective gold(i)-catalysed azo coupling of 1,2- and 1,4-diazoquinones with 1H-indoles to give a wide range of (E)-3-arylazoindoles is reported.
Study of the electronic effect and quantitative spectra predictions of o-methoxyaniline-terminated monoazonaphthols: a combined experimental and DFT study
Authors: Zhu Guoxun , Lin Yan , Zhou Wenxian , Song Huacan , Li Zhengquan
Published: November 2023

A combined experimental and DFT study on the UV-Vis spectra of o-methoxyaniline-terminated mono azo dyes was conducted. This revealed excitation mechanisms about the UV-Vis spectra formation, and explained how chemical structures influenced transition dipole moments, and spectra features.
High-performance flexible strain sensors based on silver film wrinkles modulated by liquid PDMS substrates
Authors: Xu Yifan , Chen Miaogen , Yu Senjiang , Zhou Hong
Published: November 2023

We developed a facile technique to prepare high-performance flexible strain sensors based on controllable wrinkles by depositing silver films on liquid polydimethylsiloxane (PDMS) substrates.
Layered sodium titanate with a matched lattice: a single ion conductor in a solid-state sodium metal battery
Authors: Ma Xuanao , Liu Yang , Zhang Yunhuai , Gong Yun
Published: November 2023

The layered Na0.98Ti1.3O3 (NTO) sheet is matched with Na in the lattice, which behaves like a single ion conductor with a high ion transference number due to the weak interactions between the lamellar Na+ ions and unmoved anionic Ti–O–Ti layers in NTO.
Trans-cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 α-d-mannosidases through a bump–hole strategy
Authors: Males Alexandra , Kok Ken , Nin-Hill Alba , de Koster Nicky , van den Beukel Sija , Beenakker Thomas J. M. , van der Marel Gijsbert A. , Codée Jeroen D. C. , Aerts Johannes M. F. G. , Overkleeft Herman S. , Rovira Carme , Davies Gideon J. , Artola Marta
Published: November 2023

1,6-Trans-manno-cyclosulfamidate 6 inhibits selectively an L310S mutant of Caulobacter GH47 α-d-mannosidase by virtue of its 1C4 conformation and bump-and-hole strategy, enabling allele-specific inhibition within the GH47 α-mannosidase family.
para-Selective dearomatization of phenols by I(i)/I(iii) catalysis-based fluorination
Authors: Stünkel Timo , Siebold Kathrin , Okumatsu Daichi , Murata Kazuki , Ruyet Louise , Daniliuc Constantin G. , Gilmour Ryan
Published: November 2023

The regio- and enantio-selective dearomatization of phenols has been achieved by I(i)/I(iii) catalysis enabled fluorination.
Tailoring the supramolecular interaction of ionic liquids for high-sensitivity temperature monitoring under high pressure
Authors: Xu Beihang , An Yao , Zheng Xinjia , Chen Zhiwu , Yang Zhaoxiang , Yang Yongjia , Zhang An , Wang Yapei , He Yonglin
Published: November 2023

By modulating the supramolecular interactions within ionic liquids to enhance temperature sensitivity, we have further engineered a high-pressure-resistant temperature sensor.
Emerging perspectives on 3D printed bioreactors for clinical translation of engineered and bioprinted tissue constructs
Authors: Thangadurai Madhumithra , Srinivasan Sai Sadhananth , Sekar Muthu Parkkavi , Sethuraman Swaminathan , Sundaramurthi Dhakshinamoorthy
Published: November 2023

Bioreactors aid in the functional maturation of tissue engineered/bioprinted constructs by mimicking the native microenvironment and cues. These functionally matured constructs are suitable for transplantation applications.
Enhanced flexural strength and microwave dielectric properties of Li2MgTi3O8-based low temperature co-fired ceramics
Authors: Deng Haiqing , Qu Xin , Gao Pengxiang , Liu Yang , Chen Weilin , Chen Xiuli , Zhou Huanfu
Published: November 2023

The flexural strength of LMT-NFM ceramics reaches a maximum of 200.98 MPa, which is 101.9% higher than that of pure LMT ceramics.
Reasonable construction of a bimetallic organic framework MIL-88B (Fe, Ni) nanoenzyme based on deep learning assisted doxycycline hydrochloride and methyloxytetracycline hydrochloride
Authors: Sun Mengmeng , Pu Kaixin , Hao Xingrong , Liu Tao , Lu Zhiwei , Su Gehong , Wu Chun , Wang Yanying , Cai Shuang , Zhao Xiaoqing , Rao Hanbing
Published: November 2023

The MIL-88B (Fe, Ni) colorimetric intelligent sensing platform can monitor the concentration of MET and DOX in real-time.
A revolution in sight: using induced pluripotent stem cells to investigate diseases of the retinal pigment epithelium
Authors: Alonso-Carriazo Fernandez Ana , Butt Zaynab , Foster Evangeline , Carr Amanda-Jayne
Published: November 2023

Macular diseases are one of the leading causes of vision loss in the western world. In the UK alone, almost 1.5 million people suffer from these devastating diseases, which primarily affect the macula, a region in the retina responsible for detailed central vision. In many patients, cellular changes, attributable to ageing or inherited mutations, are associated with the retinal pigment epithelium (RPE), a single layer of cells that sustains and supports the light-sensitive retina. In the absence of functional RPE, the retina becomes damaged and vision deteriorates. Currently, there are no treatments for these diseases. Over the last two decades, induced pluripotent stem cells have revolutionized our study of retinal disorders, enabling researchers to produce previously inaccessible RPE cells in a dish. The ability to recreate these cells from patients has provided new model systems to understand the mechanisms behind the disease and accelerate the development of new therapies to treat sight loss.
Nutrient Content and Sensory Characteristics of Tuna Fish Dimsum (Yellowfin)
Authors: Suzan Triyastuti Meilya , Wijaya Novie , Kurnia Dewi Luthfi , Indah Budiarti Gita
Published: November 2023

Yellowfin tuna contains glutamic acid which creates a savory taste. Tuna trimming is a by-product of the trimming process in the formation of tuna loin. Utilization of tuna trimming to produce food products that are nutritious and acceptable to the community. The objective of this research is to determine the nutritional content and preference level of tuna fish in the production of dimsum. Determination of product acceptance using hedonic tests and statistical tests. The nutritional content uses parameters of protein content, fat content, ash content and water content. Assessment of the level of preference (hedonic test) using the parameters of appearance, aroma, taste, texture and overall acceptance. Data were analyzed using the statistical software SPSS Statistic 24. The results showed that the nutritional content of steamed tuna dimsum without MSG was protein content of 14.50%wb, fat content of 1.24%wb, ash content of 1.62%wb, moisture content of 51 .73%. The nutritional content of this tuna dimsum complies with the SNI for fish dimsum products. The panelists liked the hedonic test results on tuna dimsum using the steaming and frying method with hedonic test scores above 7. The statistical test results on taste parameters using the frying and steaming method affected the panelist’s preference level.
A Review: End Of Life Reverse Osmosis Membrane Conversion And Its Prospects In The Study Of Conversion To Reconditioned Membrane
Authors: Putri R.R. Dewi , Widiasa I. Nyoman , Susanto Heru
Published: November 2023

Reverse Osmosis (RO) is the most widely applied water purification technology worldwide. However, RO membranes have a short service life before they become waste (End of Life RO/EoL RO), so they must be incinerated or disposed of in landfills. Several sustainability solutions have been proposed and studied in recent years. Therefore, a comprehensive review of the emerging trends in the reuse of EoL RO membranes is presented in this paper. Recycling EoL RO membranes is the most preferred option to solve this waste problem either as direct reuse or after conversion into other types of membranes. Direct reuse of EoL RO membranes can be divided into three categories, such as rejuvenation of EoL RO membranes, use at lower rates of treatment, and use for new applications. Rejuvenation of EoL RO can be done by cleaning treatment, use at a lower level can be done by converting it into NF, UF or MF membranes and EoL RO can be made into recycled products by utilizing parts of the EoL RO membrane module. A review of prospects and challenges faced in the conversion process into reconditioned membranes is also presented in this paper.
Slope Risk Management System on Toll Road: A case study Semarang-Salatiga Section
Authors: Hermawan Ferry , Maulana Malik , Ismiyati  , Indarto Himawan , Pamungkas Goji
Published: November 2023

Landslide is a geohazard event which can be caused by several factor, such as high rainfall intensity, slope geological feature and the slope geometry itself. Tropical wet climate and typical geomorphology of Indonesia derives landslide event as common disaster during the wet season. Nowadays, the paradigm in road slope management has changed to put the Slope as an Asset, like other infrastructure. In this case study, a slope risk management system was created to assist road slope managers in planning periodic monitoring and maintenance. As the building have the BIM System, the slope can also be digitalized as GeoBIM. Based on case studies, this system can be used to inventory and create an electronic database of road slope assets. Furthermore, the road slope assets are assessed and prioritized based on geological hazards and economic consequences. In the end, each slope asset will have routine maintenance schedules, costs, and a historical data of repairs and damage. Therefore, the slope asset can be handled effectively and efficiently.
Building Economic Competitiveness In Central Java based on Information Technology and Locality
Authors: Puspita Rosana Eri , Saifudin  , Nur Mustofa Huri , Widyastuti Emy , Al Mumtaz Ni'am
Published: November 2023

Collaboration with technology is the best strategy to create regional competitiveness in this era. However, adjustments to locality elements must still be included because it is the key and capital of success. The purpose of this study is to develop a strategy to build the competitiveness of the Central Java region based on technology and locality with the Pentahelix approach. The method used in this research is Research and Development (R&D). The study is based on qualitative research with the Pentahelix approach. The second stage is developing a technology and locality-based platform implemented in one of the districts in Central Java. The results of the first research phase are in the form of an analysis of the conditions of Central Java which can be capital in increasing regional competitiveness and can be realized in the form of a digital platform with the Pentahelix approach. The results of the second study are digital platforms in the form of technology and locality-based apps. The new thing offered in this research is the R&D method used to develop a strategy to increase the competitiveness of the Central Java region.
Developing the assesment of online vocational college students’ reading comprehension test rubrics
Authors: Ratna Maharani , Saputri Lenggahing , Aqolima Untsa
Published: November 2023

Reading is one of the four language skills includes reading as one of its abilities. Reading is frequently a challenge for English language learners, particularly in terms of vocabulary acquisition. In addition to this, additional factors impede the reading comprehension of English learners. This research seeks to develop a rubric for assessing the reading skills of English language learners. This study focuses on the VELT questions, which are a specialized English proficiency exam for vocational school students. This research employs the Research and Development methodology. The results of this study indicate that there are four benchmarks for the reading abilities of English language learners: excellent, decent, satisfactory, and poor.
Corporate Governance in the Digital Age: A Comprehensive Review of Blockchain, AI, and Big Data Impacts, Opportunities, and Challenges
Authors: Fahlevi Mochammad , Moeljadi  , Aisjah Siti , Djazuli Atim
Published: November 2023

This research examines the intersection of disruptive technologies specifically blockchain, AI, and Big Data with corporate governance, synthesizing insights from a diverse range of scholarly works. This research employed a comprehensive literature review methodology. We sourced and analyzed scholarly articles and papers from prominent databases, focusing on key themes such as the impact of these technologies on corporate governance, potential benefits, and associated challenges. We investigate the implications of these technologies on corporate governance, scrutinizing potential benefits and associated challenges. Our findings reveal that blockchain, with its potential to enhance transparency and reduce information asymmetry, promises to transform accounting and auditing practices. Nevertheless, the successful integration of blockchain into mainstream financial systems necessitates addressing technical and regulatory challenges. AI's potential to augment decision-making capabilities offers opportunities for improved auditing efficiency, yet raises ethical concerns and implementation complexities. Lastly, Big Data presents opportunities for driving sustainable innovation and informed decision-making, while posing significant challenges concerning data privacy and security. This study's findings carry implications for practitioners, policy-makers, and academics alike, providing critical insights into the dynamic interplay between disruptive technologies and corporate governance. Future research may extend this work through empirical studies and comparative analyses across industries and regions.
Municipal wastewater treatment and recycle by an electrocoagulation process and a submerged membrane bioreactor system
Authors: Zakoor Yousif , Gzar Hatem , Zakur Yahya
Published: November 2023

To remove phosphates and nitrates from municipal wastewater, an electrocoagulation process with membrane bioreactor process (EC-MBR) was used. Experiments were carried out incrementally to evaluate the new design. In a lab-scale (EC-MBR) treatment of municipal wastewater, the structure and distribution of the organic matter removal utilizing the membrane are being examined. The study's objectives were to evaluate the efficiency of the Al-Hawraa wastewater's organic matter removal process for nitrate (NO-3) and phosphate (PO4-3) as well as how it related to machine learning indicators. It was chosen to use an EC-MBR with operational parameters of 25 Co, pH 7 and DO (4-6 mg/L), initial and final concentrations of NO-3 (4.4-0.6 mg/L), and (PO4-3) (6.0-0.1 mg/L) to collect and analyze effluent from municipal wastewater treated using biological and chemical methods. According to the results, it may be possible to measure the effectiveness of organic matter removal using a neural network method. The results also showed that an overall reactor had agreeablemaximum NO-3 and (PO4-3) removal efficiencies of (87.6% and 98.1%), respectively. The accuracy model by its (98.1 and 85.7) for both NO-3 and (PO4-3) was effective, according to the models' accuracy results.
Curtain Grouting Effectivity Analysis On Foundation Rocks In Blocks 37 – 40 In The Body Of Randugunting Dam, Blora Regency, Central Java
Authors: Widiarso Dian Agus , Firman Tieties , Marin Jenian
Published: November 2023

Blora Regency is a barren area in Indonesia and has drought disaster potential, to address those problems Indonesian Governments launched Randugunting Dam’s construction program. The research area was located at Block 37 – 40, Radugunting Dam, Japah District, Blora Region. Dam as a water retention building should have foundation rocks that are resistant towards seepage potential, therefore curtain grouting was conducted to seal geological fractures on the foundation rocks. The purpose of these research was to understand the seepage potential on foundation rocks, foundation rocks curtain grouting requirement, and curtain grouting effectiveness. Research method used were water pressure test (WPT) data analysis, in the form of water flow discharge data processed through calculation to produces Lugeon value (Lu). The Lugeon value (Lu) would be further analyzed to determine the curtain grouting effectiveness value. The result of the analysis shows that around 18.15% of the research area have seepage potential that was shown by medium (3 < Lu < 10) – high (Lu > 10) Lugeoun (Lu) value. After the curtain grouitng was conducted, it effectiveness value on Block 37 was 88.34% (good), on Block 38 was 81.43% (good), on Block 39 was 70,62% (good), and on Block 40 was 79.41% (good).
Carbon Emissions Analysis of Modular House Construction
Authors: Utomo Dwi Hatmoko Jati , Agung Wibowo Mochamad , Prasetyo Ferhandi
Published: November 2023

Amidst the pressing issue of the climate crisis, the concern of housing backlog requires sustained and intensive growth in housing construction. To address this challenge while also considering environmental impacts, the Indonesian Government has prepared various strategies, one of which involves adopting a modular construction approach. This method is believed to be fast, efficient, and environmentally friendly. Despite its perceived benefits, some critics argue that the environmental advantage of the modular construction approach remains unclear, as it increases transportation activity. This study dives into the process of modular house construction and quantifies the environmental impacts of each stage involved in the process. It is found that the environmental impacts of all stages in the construction process amount to 1588.44 kgCO2. Among these stages, the raw materials extraction stage holds the largest contribution share, accounting for 94% of the total emissions. In contrast, stages related to transportation activity have a relatively low contribution share, which is 2.5%. To mitigate this impact, practitioners could optimize building design, reduce the use of high embodied carbon materials, and improve workers' competency.