bluuebunny/crossref_metadata_2025 huggingface dataset:
Wechsler Intelligence Scale for Children, Fifth Edition Profiles of Children With Autism Spectrum Disorder Using a Classification and Regression Trees Analysis
Authors: Dale Brittany A. , Finch W. Holmes , Shellabarger Kassie A. R. , Davis Andrew
Published: June 2021

The Wechsler Intelligence Scales for Children (WISC) are the most widely used instrument in assessing cognitive ability, especially with children with autism spectrum disorder (ASD). Previous literature on the WISC has demonstrated a divergent pattern of performance on the WISC for children ASD compared to their typically developing peers; however, there is a lack of research concerning the most recent iteration, the Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V). Due to the distinctive changes made to the WISC-V, we sought to identify the pattern of performance of children with ASD on the WISC-V using a classification and regression (CART) analysis. The current study used the standardization sample data of the WISC-V obtained from NCS Pearson, Inc. Sixty-two children diagnosed with ASD, along with their demographically matched controls, comprised the sample. Results revealed the Comprehension and Letter-Number Sequencing subtests were the most important factors in predicting group membership for children with ASD with an accompanying language impairment. Children with ASD without an accompanying language impairment, however, were difficult to distinguish from matched controls through the CART analysis. Results suggest school psychologists and other clinicians should administer all primary and supplemental subtests of the WISC-V as part of a comprehensive assessment of ASD.
Active Learning by Visual Programming: Pedagogical Perspectives of Instructivist and Constructivist Code Teachers and Their Implications on Actual Teaching Strategies and Students’ Programming Artifacts
Authors: Kesler Avital , Shamir-Inbal Tamar , Blau Ina
Published: June 2021

The integration of visual programming in early formal education has been found to promote computational thinking of students. Teachers' intuitive perspectives about optimal learning processes – "folk psychology" – impact their perspectives about teaching "folk pedagogy" and play a significant role in integrating educational technologies, such as visual programming, within the formal curriculum. This study was conducted based on the mixed method research paradigm. First, a folk pedagogy questionnaire was distributed to 89 teachers who integrate differing technologies in their classroom in order to identify the teachers' pedagogical perspectives: constructivist versus instructivist. Then, semi-structured interviews were conducted with 24 teachers who teach Scratch in order to gain a deeper understanding of their instructivist/constructivist perspectives and actual pedagogical practices and strategies. Finally, we analyzed 96 students' programming artifacts to explore differences, if any, in students' outcomes related to the pedagogical perspectives of their teachers. Findings revealed that pedagogical perspectives are reflected in teaching strategies and assessment practices employed in a visual programming environment. It is promising that teaching visual programming promoted constructivist pedagogy even among instructivist teachers and was consequently reflected in student perspectives and expressed in their programming artifacts. We discuss theoretical and educational implications of these findings.
Performance of the APACHE II and SOFA Scores in Diabetic Ketoacidosis
Authors: Hansen Christopher K. , Issa Mahmoud , Balaji Lakshman , Du Amanda , Grossestreuer Anne V. , Donnino Michael
Published: June 2021

Accurate prediction of severity and mortality in diabetic ketoacidosis (DKA) is important for allocation of resources. The APACHE II and SOFA scores are used to predict mortality in critically ill patients, however neither has been tested exclusively in DKA. We sought to determine if these scoring systems can accurately predict mortality in patients with DKA. This was an observational study of patients presenting to an urban tertiary care center with a diagnosis of DKA. Adult patients (age ≥ 18 years) with glucose > 250 mg/dL, bicarbonate ≤ 20 mEg/L, an anion gap ≥ 16 mEg/L, pH ≤ 7.30, and urine ketones were included. Predicted mortality based upon APACHE II and SOFA scores were compared to observed mortality. A total of 50 patients were included. There was no observed mortality in our population. The median APACHE II score was 10 (IQR: 6, 15) which predicted a mortality of 15% and the median SOFA score was 1 (IQR: 0, 2) which predicted a mortality of 0%. In summary, we found the APACHE II illness severity score does not accurately predict mortality in a population of patients with DKA, while the SOFA score appears to predict mortality in the same population.
A Dual-Process Approach to Moral Panic and Public Support for Sex Offender Management Policies
Authors: Berryessa Colleen M.
Published: June 2021

The current study explores if and how dual-process thinking styles (System I/experiential and System II/rational processing) predict and explain the degree to which members of the public express moral panic toward and support for existing sex offender management policies (registration, notification, residence restrictions), regardless of their efficacy or effects on recidivism rates, for different types of individuals who commit sex offenses (sex offender, juvenile sex offender, cybersex offender, female sex offender, rapist, child molester). Online experimental methods were used with a lay sample ( N = 324). Results show that the extent to which participants exhibited a reliance on System I processing significantly predicted their feelings of moral panic (concern, hostility, and volatility) toward individuals classified as child molesters. Further, feelings of concern, hostility, and volatility, as significant predictors of support for existing sex offender management policies for individuals classified as child molesters, were found to increase as a function of participants’ reliance on the System I, experiential thinking style. Implications of this work, specifically related to addressing public support for existing sex offender management policies for individuals classified as child molesters, are discussed.
Measuring Procedural Justice Policy Adherence During Use of Force Events: The Body-Worn Camera as a Performance Monitoring Tool
Authors: Sytsma Victoria A. , Piza Eric L. , Chillar Vijay F. , Grossman Leigh S.
Published: June 2021

This study capitalizes on a successful researcher–practitioner partnership to conduct a systematic social observation (SSO) of police body-worn camera (BWC) footage in Newark, NJ. To demonstrate the utility of BWCs as performance monitoring tools, we measure officer adherence to procedural justice standards throughout use of force events as mandated in the Newark Police Division’s updated policies pursuant to an ongoing federal consent decree. Overall, a slim majority of use of force events are procedurally just. However, results indicate several instances of policy noncompliance. Results are discussed, and policy recommendations related to procedural justice policy violations and BWCs for performance monitoring are provided.
Liminality, third-culture and hope in a quarantine camp
Authors: Nguyen Minh-Hoang
Published: June 2021

Through the experience of a quarantine camp in Vietnam, the essay discusses how the experience was a third-culture phenomenon in overdrive because of spatial and social isolation. Through such resemblance, the author points toward a path to understanding and embracing third-culture in the larger context of globalization.
Never again? The role of the global network of R2P focal points in preventing atrocity crimes
Authors: Mennecke Martin
Published: June 2021

The Nuremberg judgement famously held that crimes against international law are committed by men, not by abstract entities – but who, then, is to prevent these crimes? In 2005, all UN Member States agreed that it was their responsibility to protect populations against atrocity crimes (short R2P). In 2010, the idea was born to appoint senior government officials to act as individual R2P Focal Points to help implement this historic pledge. This article critically examines the focal point idea and its practice, focusing on the experience of the Danish R2P Focal Point as well as the role of the Global Network of R2P Focal Point which today has members from 61 UN member states. The article highlights the significant potential of the R2P Focal Points but also a series of pre-conditions that need to be met if the appointment of a R2P Focal Point is not to remain a mere gesture.
An anti-lock braking system algorithm using real-time wheel reference slip estimation and control
Authors: Gaurkar Pavel Vijay , Ramakrushnan Karthik , Challa Akhil , Subramanian Shankar C , Vivekanandan Gunasekaran , Sivaram Sriram
Published: June 2021

Knowledge of the tyre-road interface traction limit during braking of a road vehicle can drastically improve safety and ensure stable braking on varied road conditions. This study proposes an optimal reference slip algorithm that determines the road surface while the vehicle is braking, by implicitly tracking the traction limit. It presents wheel slip variance regulation as a potential approach towards reference wheel slip estimation for wheel slip regulation (WSR). The variance regulation approach computes reference wheel slip using past wheel slip estimates and regulates wheel slip variation at a set point. This variance regulation problem was solved using least-squares estimation, yielding reference slip dynamics. A 3-staged nested control architecture was developed with reference slip dynamics to yield an anti-lock braking system (ABS) algorithm consisting of a brake controller, WSR algorithm and reference slip estimation. The algorithm was experimentally corroborated in a Hardware-in-Loop setup consisting of the pneumatic brake system of a heavy commercial road vehicle, and IPG TruckMaker®, a vehicle dynamics simulation software. The proposed ABS algorithm was tested on straight roads with homogeneous surfaces, split friction surfaces, and transition friction surfaces. It ensured stable braking in all road cases, with a 7%–18% reduction in braking distance on homogeneous road surfaces compared to the same vehicle without ABS. The vehicle directional stability was retained on a split-friction surface, and the ABS algorithm was observed to adapt to sudden transitions in the road surface.
Virginie Despentes’ queer crime fiction
Authors: Hollister Lucas
Published: June 2021

Virginie Despentes has become one of France’s most commercially successful and celebrated novelists. However, while the French press has often labelled Despentes’ novels as crime fiction (‘polars’), there has been little in-depth scholarly discussion of how her work engages and transforms the conventions of the genre. Studies of Despentes’ queer/feminist themes and rhetoric would benefit from a more sustained attention to her ambivalent appropriations of the masculinist tropes of brutal crime fiction, and studies of French crime fiction would benefit from considering Despentes as key figure in the development of French queer/feminist crime fiction. Examining novels ranging from Baise-moi to Apocalypse bébé, this article argues for the interest in reading them as crime fiction, and notably as works that underline the risks that accompany efforts to rewire masculinist genres from within and orient them towards feminist and queer concerns.
Border identities: Theoretical approach to the study of self from bordering processes
Authors: Español Alicia , de la Mata Manuel L. , Cornejo Marcela
Published: June 2021

This article develops a theoretical approach to the study of identity narratives from the concept of the bordering process. The first section describes the theoretical concepts that sustain the proposal, in particular, the concept of border as a mediating artifact, the theoretical concept of the bordering process as a social practice, and finally, identity narratives and the dialogical perspective of the self. The second section analyzes the proposals and limitations of some studies on identity narratives in international borderlands. In the same section, we develop our theoretical proposal for studying border identity narratives, which attempts to overcome some limitations of previous studies and respond to the debate on the role of others in the construction of the self. We conclude that the inclusion of the border as a semiotic artifact and the bordering process in the construction of the self provide a new perspective of identity narratives as border narratives for the study of border experiences throughout human development.
Exploring consequences of simulation design for apparent performance of methods of meta-analysis
Authors: Kulinskaya Elena , Hoaglin David C. , Bakbergenuly Ilyas
Published: June 2021

Contemporary statistical publications rely on simulation to evaluate performance of new methods and compare them with established methods. In the context of random-effects meta-analysis of log-odds-ratios, we investigate how choices in generating data affect such conclusions. The choices we study include the overall log-odds-ratio, the distribution of probabilities in the control arm, and the distribution of study-level sample sizes. We retain the customary normal distribution of study-level effects. To examine the impact of the components of simulations, we assess the performance of the best available inverse–variance–weighted two-stage method, a two-stage method with constant sample-size-based weights, and two generalized linear mixed models. The results show no important differences between fixed and random sample sizes. In contrast, we found differences among data-generation models in estimation of heterogeneity variance and overall log-odds-ratio. This sensitivity to design poses challenges for use of simulation in choosing methods of meta-analysis.
Stem Cell-Based Therapy for Asherman Syndrome: Promises and Challenges
Authors: Gao Yiyin , Wu Guijie , Xu Ying , Zhao Donghai , Zheng Lianwen
Published: June 2021

Asherman syndrome (AS) has an adverse effect on reproductive health and fertility by affecting endometrial regeneration. Stem cell-based therapies hold promise for future use in activating non-functional endometrium and reconstructing the endometrium in vivo. It has been postulated that various endometrial stem cells (EnSCs) are responsible for endometrial regeneration. Numerous studies have focused on bone marrow-derived stem cells (BMDSCs), which may provide new ideas for repairing endometrial lesions and reconstructing the endometrium. Other sources of stem cells, such as menstrual blood, umbilical cord, and amniotic membrane, have also attracted much attention as candidates for transplantation in AS. This review discusses the features and specific biomarkers among four types of resident endometrial stem cells, applications of four different sources of exogenous stem cells in AS, and development of stem cell therapy using biomaterials and exosomes.
Examining the Legal Legitimacy of Informal Economic Activities
Authors: Routh Supriya
Published: June 2021

This article explains the disjuncture between formal parliamentary laws and norms of informal economic activities on the basis of a contextual and layered idea of legitimacy. This explanation clarifies a misunderstanding in certain scholarly and policy circles characterising informal economic activities as extra-legal or illegal. The idea of legal legitimacy helps explain divergent normative logics of formal and informal spaces while indicating that informal activities are not performed in a regulatory void. In addition to helping redefine the informal space, the idea also helps clarify the interaction between formal and informal regulation. By employing Jürgen Habermas’ analytical characterisation of society as constitutive of lifeworld(s) and system, and drawing on the empirical literature, the article argues that a cautious interpretation of Habermas’ analytical categorization helps explain the legality of the informal space. If formal laws need to become legitimate for the informal context, they must integrate the contextual standards of legitimacy recognized in the informal space.
Defending the Dardanelles: Cevat Paşa, ‘The Hero of 18 March’
Authors: Kut Gün
Published: June 2021

Cevat Paşa (General Cevat Çobanlı: 1870-1938) was an Ottoman Army officer who played a decisive role in the defence of the Dardanelles Strait against the Allied offensive during the First World War. He had been primarily responsible for the preparation and improvement of defensive plans as the commander of the Çanakkale Fortified Zone, as well as the implementation of these plans during the Allied naval assault of 19 February-18 March 1915. The ultimate failure of the offensive was mainly due to the careful planning and successful execution of defensive measures under the command of Cevat Paşa.
Ethical challenges in end-stage dementia: Perspectives of professionals and family care-givers
Authors: Hochwald Inbal Halevi , Yakov Gila , Radomyslsky Zorian , Danon Yehuda , Nissanholtz-Gannot Rachel
Published: June 2021

Background:

In Israel, caring for people with end-stage dementia confined to home is mainly done by home care units, and in some cases by home hospice units, an alternative palliative-care service. Because life expectancy is relatively unknown, and the patient’s decision-making ability is poor, caring for this unique population raises ethical dilemmas regarding when to define the disease as having reached a terminal stage, as well as choosing between palliative and life-prolonging-oriented care.

Objectives:

Exploring and describing differences and similarities of professional staff members’ (PSMs’) and family caregivers’ perceptions of caring for people with end-stage dementia in two different settings.

Design:

Qualitative research, using semi-structured interviews analyzed through a thematic content–analysis approach.

Participants:

Sixty-four interviews were conducted (24 PSMs and 40 family caregivers) in two care-settings—home hospice unit and home care unit.

Ethical considerations:

The study was approved by the Ethics Committee (BBL00118-17).

Findings:

We found dilemmas regarding palliative care to be the main theme, including definition of the disease as terminal, choosing “comfort” over “life-prolonging,” clarifying patients’ wishes and deciding whether or not to use artificial feeding.

Discussion:

Both PSMs and family caregivers deal with ethical dilemmas and have reached different conclusions, both legitimate. Comprehending dementia as a terminal disease influenced participants’ perceptions of the relevancy of palliative care for people with end-stage dementia. Discrepancies between PSMs and family caregivers in caring for people with end-stage dementia were found in both home hospice unit and home care unit environments, raising potential conflicts regarding decisions for end-of-life care.

Conclusions:

Communication between PSMs and family caregivers is crucial for the discussion about the discrepancies regarding the unique dilemmas of caring for people with end-stage dementia and bridging the gap between them. Lack of communication and resources can hamper the provision of an acceptable solution for quality and equality of care in the best interest of people with end-stage dementia.
Employment, Technology and Value Chain: A Case of Indian Leather Industry
Authors: Paul Bino , Patnaik Unmesh , Jaganth G. , Murari Kamal
Published: June 2021

India’s leather industry is an interesting case for a value chain (VC) that has unorganised and organised firms. To understand VC’s upstream, we examine a recent database on unorganised enterprises in the leather industry. First, we assess the determinants of two outcomes: value added and surplus. Second, we gauge if technology impacts employment. We use a multi-database and multi-method approach. Our analysis is based on National Sample Survey’s (NSS) 73rd Round on unincorporated non-agricultural enterprises. To understand the downstream of value-added value chain functions, capacity utilisation, last-mile delivery, product and process innovation, and orientation towards export, we use the World Bank Enterprise survey (2014). While confirming the stylised fact of the direct relationship between the firm’s resources and performance, the study emphasises the pivotal role of human capital in a firm’s performance, valid for both VC streams.
Granting the privilege to grunt: Reconceptualizing the perception of grunting in gyms
Authors: Lev Assaf , Hertzog Esther
Published: June 2021

For many gym goers, grunting in times of bodily exertion is perceived as a voluntary performance, a self-evident expression for which they can waive any responsibility. Drawing on a symbolic interaction approach, this paper provides a novel examination of grunting as a social phenomenon. It demonstrates the role of grunting as a social symbol and its connection to social spaces and identities, gender norms, and power relations. The scope of sociological research on grunting in times of bodily exertion is relatively limited and often relegated to the context of biomedicine. Therefore, the contribution of this paper is to address the lacuna of research that focuses on the link between grunting as a socially constructed phenomenon and its sociocultural implications. Ethnographic research was conducted for 3 years in two gyms, using a combination of participant observation and semi-structured interviews. Key findings illustrate three themes toward the role of grunting: grunting and socialization; grunting and space; and finally, grunting and situational adjustment. It is argued that grunting at the gym is socially constructed, a rational and voluntary action that is negotiated, controlled, and adjusted according to the situation.
‘Who unlocked the kitchen?’: Online misogyny, YouTube comments and women's professional street skateboarding
Authors: McCarthy Brigid
Published: June 2021

Abuse and harassment of sportswomen has become a global issue. And while the sportification of skateboarding has increased professional opportunities and media visibility for women athletes, it has also resulted in misogyny and gendered abuse on online platforms where competition coverage is posted. This study examines comments that collectively target competitors in YouTube streams of major professional women’s street skating competitions. Examined through the lens of ‘virtual manhood acts’, it demonstrates how gender boundaries of skateboarding are policed online through masculine acts such as gendered language, comparison, sexualisation and stigmatisation of non-normative femininities. In undertaking these virtual manhood acts, perpetrators delegitimise women skaters collectively and engage in strategies that elevate male membership in both the sport and fandom. The pervasive presence of abuse and misogyny highlights a need for further sport-specific research into behaviours which may impact athletes’ emotional and mental well-being, and create further barriers to participation, particularly in male-dominated sports cultures.
Potential Best Practices for Enhancing civic Engagement Outcomes (Field Notes)
Authors: Lefkovitz Paul M. , Pinsoneault Laura T. , Bonbright David , Nguyen Linda T.
Published: June 2021

This Field Notes brief reports on 20 potential best practices that relate to enhancing civic engagement outcomes for human service organizations as part of an initiative by the Alliance for Children and Families (Alliance) and the United Neighborhood Centers of America (UNCA). Four strategic clusters were evident in these best practices: board of directors expertise and focus, organizational infrastructure, empowerment of community residents, and tactical strategies. The best practices were identified through a process benchmarking exercise which compared the frequency of various civic engagement strategies between organizations having high levels of positive civic engagement outcomes with the frequency among organizations in a comparison group. Groups were identified using the Civic Engagement Measurement System, a set of interrelated tools developed by the Alliance and UNCA to help organizations measure concrete outcomes.
Father Involvement in the First Year After Prison: Considerations for Social Work
Authors: Charles Pajarita , Frankham Emma , Garthe Rachel C. , Visher Christy A. , Kay Anna L.
Published: June 2021

Purpose:

Paternal incarceration poses significant concerns for fathers and their children. Despite the known negative consequences, little is understood about father involvement after prison. This study aims to further understanding of fatherhood following incarceration to inform future intervention strategies.

Method:

Using data from the Urban Institute’s Returning Home: Understanding the Challenges of Prisoner Reentry Study ( N = 326), we conduct bivariate and multivariate analyses to examine three dimensions of father involvement and predictors of involvement at two time points after prison.

Results:

Findings reveal generally high levels of father involvement in the first year following incarceration. Father-child contact during prison and increased work hours after prison showed positive effects on early father involvement, while post-prison engagement and contact following release were associated with later involvement.

Conclusions:

Promoting father-child contact and positive relationships during incarceration may be important for future father involvement after release. Potential social work and criminal justice practice and research opportunities are discussed.
Pre-Hispanic Evidence of Cleft Lip and/or Palate in Mesoamerica
Authors: Aleman Ramon Manuel , Martinez Maria Guadalupe
Published: June 2021

In this letter, the authors present archeological evidence of the presence of cleft lip and/or palate (CLP) in pre-Hispanic Mesoamerica. During years 2016 and 2017, the authors visited 5 anthropology museums in Mexico, Guatemala, and El Salvador, in search for pre-Hispanic archeological evidence of CLP, and 16 anthropomorphic figurines with evidence of CLP were identified; 9 at the Anahuacalli Museum, 6 at the National Anthropology Museum of Mexico, and 1 at the National Anthropology Museum of El Salvador. Fifteen of these ceramics originated from the shaft tombs (pre-Hispanic culture from western Mexico, Jalisco, Colima, and Nayarit; dating from 200 bc-600 ad), and 1 ceramic originated from the Cotzumalguapa (a pre-Hispanic culture from western El Salvador dating from 200 ad-900 ad).
An Investigation Into the Perceptions of Teachers and Students in Mexico on the Implementation of Secondary Reforms
Authors: Joong Yee Han Peter
Published: June 2021

This mixed methods study examines how secondary school teachers have implemented educational reforms in Mexico. Major sources of data were surveys from sample teachers and students in 12 schools on how often a teaching or evaluation strategy was used. Results from open-ended questions and classroom observations were used to triangulate results from survey data. The study concluded that most teachers were able to adopt majority of the reforms. Even though teacher-directed lessons still dominated, student-centered learnings were incorporated. However, classroom management need increased attention due to new challenges of transitioning. Educators in all jurisdictions can learn from the reform efforts.
The Value of Learning Collective Free Music Improvisation: Preservice Music Educators’ Perspectives
Authors: Ng Hoon Hong
Published: June 2021

I conducted a case study to explore preservice music teachers’ behaviors, thoughts, and feelings when engaged in collective free music improvisation. Nine preservice music teachers were taught how to freely improvise within groups as part of a teacher education course and participated in interviews and focus group discussions. Major themes highlighted learning across three segments that emphasized communication and collaborative skills, entrepreneurial skills and risk taking, and reconciliation and transformation. I concluded that the sociomusical outcomes produced by collective free improvisation may complement those of more formal and idiomatic improvisation practices, and that by introducing preservice music teachers to free improvisation activities, they may be more willing to engage PK–12 students in free improvisation lessons that enhance the existing school music curriculum.
Analysis of the Clinical Characteristics of Dipeptidyl Peptidase-4 Inhibitor–Induced Bullous Pemphigoid
Authors: Sun Linli , Wang Chunxia , Wu Cuifang , Zhou Yulu , Wang Chunjiang
Published: June 2021

Objective

To analyze and discuss the clinical characteristics of dipeptidyl peptidase-4 inhibitor (DPP4i)-induced bullous pemphigoid (BP).

Data Sources

We collected case reports of DPP4i-induced BP by searching databases from 2006 to mid-May 2021, as a retrospective analysis.

Study Selection and Data Extraction

Relevant case reports and case analyses of DPP4i-induced BP were included.

Data Synthesis

The median time of symptom onset was 9 months (range 0.5-59 months). BP most often occurred in patients receiving vildagliptin (52.63%) followed by linagliptin (27.19%) and sitagliptin (17.54%). Tense bullae and blisters (85.51%) and erythema (82.61%) on the extremities and trunk were the most common presenting symptoms. In total, 64.06% of BP patients were anti-BP180 autoantibody positive, 58.97% were BP180NC16a autoantibody positive, and 31.25% were anti-BP230 autoantibody positive. Skin biopsy revealed subepidermal bulla eosinophil infiltration in 93.85% of BP patients, lymphocyte infiltration in 56.93%, and neutrophil infiltration in 44.62%. Direct immunofluorescence was positive in 98.94% of BP patients with linear deposition of IgG (97.80%) and/or complement C3 (98.94%) along the basement membrane zone. Indirect immunofluorescence was positive in 87.88% of BP patients. Complete remission of BP was achieved in 83.64% of patients on DPP4i withdrawal and after 4 months (range 0.13-72 months) of follow-up.

Relevance to Patient Care and Clinical Practice

This review analyzes and discusses the clinical characteristics of DPP4i-induced BP and provides a reference for the safe and reasonable clinical application of DPP4i.

Conclusions

DPP4i drugs are related to the occurrence of BP in diabetic patients, especially elderly men taking vildagliptin.
Impact of the Subtle Lisfranc Injury on Foot Structure and Function
Authors: Garríguez-Pérez Daniel , Puerto-Vázquez María , Tomé Delgado José Luis , Galeote Enrique , Marco Fernando
Published: June 2021

Background:

The subtle Lisfranc injury is the disruption of the osteoligamentary complex between the first cuneiform and the second metatarsal, resulting in minor widening of this space that is often difficult to detect with plain radiographs. In this study, we assessed the results after treatment of the different stages of subtle Lisfranc injuries, focusing on their impact on foot arch anatomy and functionality at short- to midterm follow-up.

Methods:

A retrospective study including patients treated in our center for a subtle Lisfranc injury between 2012 and 2019 was conducted. Demographic, epidemiologic, radiographic, and clinical data were obtained and assessed, focusing on foot arch structure and foot function, which was evaluated with the American Orthopaedic Foot & Ankle Society (AOFAS) midfoot score and the Foot Function Index (FFI).

Results:

A total of 42 patients with a mean age of 49 ± 17.5 years were included, with an average of 4.3 years’ follow-up (range, 1-8). Stage I injuries according to Nunley classification represented 19% and were treated conservatively. Stage II (66.7%) and stage III (14.3%) injuries were treated operatively, via osteosynthesis with screws (74%), K-wires (19%), or plates (7%). Flattening of foot arch after treatment was observed in 42.9% of patients, with significant increases in Costa-Bertani (12 ± 7 degrees), Hibbs (7 ± 6 degrees), and Meary (3 ± 1 degrees) angles. Other complications included complex regional pain syndrome (28.6%) and painful hardware (23.8%). Secondary joint arthrodesis was needed in 16.6% of patients. Chronic pain was present in 71.4% of patients with a mean visual analog scale (VAS) pain score at final follow-up of 4 of 10 points. Results in AOFAS midfoot score and FFI were 87.4 ± 8.3 and 15 ± 6.4, respectively.

Conclusion:

The subtle Lisfranc injury shows dissociation between the initial relatively mild radiographic changes and important future complications. Chronic pain and foot arch flattening were not uncommon. Overall foot function in the short- or midterm was found to be modestly diminished in this somewhat heterogenous cohort.

Level of Evidence:

Level IV, therapeutic case series.
Measurement Invariance of the Scale of Positive and Negative Experience Across 13 Countries
Authors: Jovanović Veljko , Joshanloo Mohsen , Martín-Carbonell Marta , Caudek Corrado , Espejo Begoña , Checa Irene , Krasko Julia , Kyriazos Theodoros , Piotrowski Jarosław , Rice Sean P. M. , Junça Silva Ana , Singh Kamlesh , Sumi Katsunori , Tong Kwok Kit , Yıldırım Murat , Żemojtel-Piotrowska Magdalena
Published: June 2021

The Scale of Positive and Negative Experience (SPANE) is widely used to measure emotional experiences, but not much is known about its cross-cultural utility. The present study evaluated the measurement invariance of the SPANE across adult samples ( N = 12,635; age range = 18-85 years; 58.2% female) from 13 countries (China, Colombia, Germany, Greece, India, Italy, Japan, Poland, Portugal, Serbia, Spain, Turkey, and the United States). Configural and partial scalar invariance of the SPANE were supported. Three items capturing specific negative emotions (sad, afraid, and angry) were found to be culturally noninvariant. Our findings suggest that the SPANE’s positive emotion terms and general negative emotion terms (e.g., negative and unpleasant) might be more suitable for cross-cultural studies on emotions and well-being, whereas caution is needed when comparing countries using the SPANE’s specific negative emotion items.
The effect of a Clinical Decision Support System on the frequency of dose adjustments of anticancer drugs in case of renal or hepatic dysfunction
Authors: Rolvink José , Gerards Anne-Loes E , Kater Arnon P , Swart Eleonora L , Becker Matthijs L
Published: June 2021

Introduction

Dose adjustments in patients with renal or hepatic dysfunction using anticancer drugs are indicated according to guidelines. However, implementation depends on awareness of prescribing physicians. We implemented a Clinical Decision Support System (CDSS), recommending dose adjustments upon electronic prescriptions based on renal and hepatic function. The alert provides a dose adjustment proposal and recent laboratory results. Our objective was to determine the frequency of dose adjustments before and after implementation of this CDSS.

Methods

We included all first orders for patients ≥18 years treated with parenteral antineoplastic agents, for whom dosage adjustment is necessary based on renal or hepatic function between February 2018 and January 2019. This study was performed at the department of Clinical Oncology and Hematology of the Amsterdam University Medical Center. We implemented the CDSS August first. All prescriptions were prescribed according to common practice. We analyzed the orders where a dose reduction based on renal or hepatic function was indicated.

Results

We included 73 orders before implementation and 99 orders after implementation. Before implementation 21% of doses were reduced in line with the guidelines versus 34% after implementation (p = 0.048). For hepatic dysfunction the proportion changed from 11% to 46% p = 0.011, while there was no effect for renal dysfunction (24% vs. 26% p = 0.75).

Conclusion

Dosages are more frequently adjusted in concordance with guidelines in patients with hepatic dysfunction who are treated with parenteral antineoplastic agents after implementation of a CDSS. The change was not seen in patients with renal dysfunction.
Measuring Collateral Consequences Among Individuals Registered for a Sexual Offense: Development of the Sexual Offender Collateral Consequences Measure
Authors: Hamilton Emma , Sanchez Delida , Ferrara Matthew L.
Published: June 2021

Collateral consequences faced by individuals convicted of a sexual offense have been widely referenced in the literature. There is yet to be a systematic examination of collateral consequences affecting individuals, however, due to measurement inconsistencies and the absence of a psychometrically validated instrument. The current study developed and validated a measure of collateral consequences faced by individuals convicted of a sexual offense. Specifically, this study investigated (a) the underlying factor structure of collateral consequences commonly endorsed by individuals convicted of a sexual offense through Exploratory Factor Analysis (EFA) procedures and (b) reliability and validity indicators of the aforementioned scale. Participants were 218 individuals convicted of and registered for a sexual offense in the state of Texas. Study measures included a pool of 66 collateral consequences items in addition to psychological self-report instruments addressing hopelessness, shame, social well-being, and discrimination. EFA results revealed a two-dimensional construct representing collateral consequences affecting areas of social and psychological well-being. The current measure demonstrated adequate reliability and validity. Limitations and future directions of findings are addressed.
Feline blood donation adverse reactions: classification and description of acute and delayed reactions in a donor population
Authors: Abreu Tiago AM , Oliveira Andreia ST , Ferreira Rui RF , Correia Sandrina MV , Morais Mafalda SSQ , Soares Raquel , Flamínio Marta , Mesa-Sanchez Ignacio , Gopegui Rafael R , de Matos Augusto JF
Published: June 2021

Objectives

This article aims to analyse the safety of feline blood donation by describing the frequency and nature of any adverse reactions and their causes, as well as propose measures to decrease the incidence of adverse reactions.

Methods

In this prospective study, any blood donor adverse reactions detected by the clinical staff during and immediately after donation were recorded. The owners of the cats were also surveyed by a veterinary practitioner or veterinary nurse 5 days after donation, using a predefined questionnaire to assess for any clinical or behavioural changes. Data were collected between January 2019 and March 2020 from blood donors enrolled in an animal blood bank programme.

Results

Of 3690 blood donations from 1792 feline donors assessed, post-donation reactions were reported in 1.14% (n = 42): 0.22% (n = 8) were acute reactions, which included weakness, pallor, tachypnoea and open-mouth breathing; and 0.92% (n = 34) were delayed post-donation reactions, with 0.16% involving cutaneous (haematomas and skin rashes, n = 6), 0.68% involving behavioural (n = 25) and 0.08% involving digestive (emesis and inappetence, n = 3) signs.

Conclusions and relevance

The low incidence of post-donation reactions in this study is encouraging, suggesting that a well-established protocol and competent staff can help to ensure a high level of safety in a feline donor programme and, in turn, increase the confidence of cat owners.
Short peripheral intravenous catheter securement with cyanoacrylate glue compared to conventional dressing: A randomized controlled trial
Authors: Bahl Amit , Gibson S. Matthew , Jankowski David , Chen Nai-Wei
Published: June 2021

Background:

Short peripheral intravenous catheters (PIVCs) fail prior to completion of therapy in up to 63% of hospitalizations. This unacceptably high rate of failure has become the norm for the most common invasive procedure in all of medicine. Securement strategies may improve PIVC survival.

Methods:

We conducted a prospective, single-site, parallel, two-arm randomized controlled investigation with a primary outcome of catheter failure comparing securement with standard semi-permeable dressing and clear tape (SPD) to standard semipermeable dressing and clear tape with cyanoacrylate glue (SPD + CG). Adult emergency department patients with a short PIVC and anticipated hospital duration ⩾ 48 h were enrolled and followed until IV failure or completion of therapy for up to 7 days. Secondary outcomes included complications and cost comparisons between groups. Primary outcome was assessed by intention to treat and per protocol analyses.

Findings:

350 patients were enrolled between November 2019 and October 2020. PIVC survival for SPD + CG was similar to SPD group with the absolute risk difference of IV failure in the intention-to-treat (−5.8%, p = 0.065) population and improved in the per protocol (−8.1%, p = 0.04) population, respectively. Kaplan-Meier survival analysis indicated there was a significant benefit of the SPD + CG at greater than 2 days of hospitalization ( p = 0.04). Prior to 48 h, there was no survival enhancement to either group ( p = 0.98) in the intention to treat population. In a multivariable analysis with piecewise Cox regression, when the IV was functional greater than 48 h, the risk of IV failure in the SPD + CG was 43% less than the SPD group (adjusted hazard ratio [HR] 0.57, 95% confidence interval [CI] 0.34 to 0.97; p = 0.04). Cumulative cost related to IV during hospitalization was similar between groups with a lower incremental rescue cost in the SPD + CG group.

Interpretation:

SPD combined with cyanoacrylate glue provides similar benefit to patients compared to SPD alone and potentially improves short PIVC survival when the IV was inserted >48 h. As this strategy is cost neutral, it could be considered in admitted patients, particularly those with longer anticipated hospital durations.
Insights into Bacterial Community Involved in Bioremediation of Aged Oil-Contaminated Soil in Arid Environment
Authors: Rahmeh Rita , Akbar Abrar , Kumar Vinod , Al-Mansour Hamad , Kishk Mohamed , Ahmed Nisar , Al-Shamali Mustafa , Boota Anwar , Al-Ballam Zainab , Shajan Anisha , Al-Okla Naser
Published: June 2021

Soil contamination by hydrocarbons due to oil spills has become a global concern and it has more implications in oil producing regions. Biostimulation is considered as one of the promising remediation techniques that can be adopted to enhance the rate of degradation of crude oil. The soil microbial consortia play a critical role in governing the biodegradation of total petroleum hydrocarbons (TPHs), in particular polycyclic aromatic hydrocarbons (PAHs). In this study, the degradation pattern of TPHs and PAHs of Kuwait soil biopiles was measured at three-month intervals. Then, the microbial consortium associated with oil degradation at each interval was revealed through 16S rRNA based next generation sequencing. Rapid degradation of TPHs and most of the PAHs was noticed at the first 3 months of biostimulation with a degradation rate of pyrene significantly higher compared to other PAHs counterparts. The taxonomic profiling of individual stages of remediation revealed that, biostimulation of the investigated soil favored the growth of Proteobacteria, Alphaprotobacteria, Chloroflexi, Chlorobi, and Acidobacteria groups. These findings provide a key step towards the restoration of oil-contaminated lands in the arid environment.
DGraph Clusters Flaviviruses and β-Coronaviruses According to Their Hosts, Disease Type, and Human Cell Receptors
Authors: Braun Benjamin A , Schein Catherine H , Braun Werner
Published: June 2021

Motivation:

There is a need for rapid and easy-to-use, alignment-free methods to cluster large groups of protein sequence data. Commonly used phylogenetic trees based on alignments can be used to visualize only a limited number of protein sequences. DGraph, introduced here, is an application developed to generate 2-dimensional (2D) maps based on similarity scores for sequences. The program automatically calculates and graphically displays property distance (PD) scores based on physico-chemical property (PCP) similarities from an unaligned list of FASTA files. Such “PD-graphs” show the interrelatedness of the sequences, whereby clusters can reveal deeper connectivities.

Results:

Property distance graphs generated for flavivirus (FV), enterovirus (EV), and coronavirus (CoV) sequences from complete polyproteins or individual proteins are consistent with biological data on vector types, hosts, cellular receptors, and disease phenotypes. Property distance graphs separate the tick- from the mosquito-borne FV, cluster viruses that infect bats, camels, seabirds, and humans separately. The clusters correlate with disease phenotype. The PD method segregates the β-CoV spike proteins of severe acute respiratory syndrome (SARS), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and Middle East respiratory syndrome (MERS) sequences from other human pathogenic CoV, with clustering consistent with cellular receptor usage. The graphs also suggest evolutionary relationships that may be difficult to determine with conventional bootstrapping methods that require postulating an ancestral sequence.
Inhibitory Potential of Phytochemicals on Interleukin-6-Mediated T-Cell Reduction in COVID-19 Patients: A Computational Approach
Authors: Malik Arif , Naz Anam , Ahmad Sajjad , Hafeez Mansoor , Awan Faryal Mehwish , Jafar Tassadaq Hussain , Zahid Ayesha , Ikram Aqsa , Rauff Bisma , Hassan Mubashir
Published: June 2021

Background:

A recent COVID-19 pandemic has resulted in a large death toll rate globally and even no cure or vaccine has been successfully employed to combat this disease. Patients have been reported with multi-organ dysfunction along with acute respiratory distress syndrome which implies a critical situation for patients and made them difficult to breathe and survive. Moreover, pathology of COVID-19 is also related to cytokine storm which indicates the elevated levels of interleukin (IL)-1, IL-6, IL-12, and IL-18 along with tumor necrosis factor (TNF)-α. Among them, the proinflammatory cytokine IL-6 has been reported to be induced via binding of severe acute respiratory syndrome coronavirus 2 (SARS)-CoV-2 to the host receptors.

Methodology:

Interleukin-6 blockade has been proposed to constitute novel therapeutics against COVID-19. Thus, in this study, 15 phytocompounds with known antiviral activity have been subjected to test for their inhibitory effect on IL-6. Based on the affinity prediction, top 3 compounds (isoorientin, lupeol, and andrographolide) with best scores were selected for 50 ns molecular dynamics simulation and MMGB/PBSA binding free energy analysis.

Results:

Three phytocompounds including isoorientin, lupeol, and andrographolide have shown strong interactions with the targeted protein IL-6 with least binding energies (−7.1 to −7.7 kcal/mol). Drug-likeness and ADMET profiles of prioritized phytocompounds are also very prominsing and can be further tested to be potential IL-6 blockers and thus benficial for COVID-19 treatment. The moelcular dynamics simulation couple with MMGB/PBSA binding free energy estimation validated conformational stability of the ligands and stronger intermolecular binding. The mean RMSD of the complexes is as: IL6-isoorientin complex (3.97 Å ± 0.77), IL6-lupeol (3.97 Å ± 0.76), and IL6-andrographolide complex (3.96 Å ± 0.77). In addition, the stability observation was affirmed by compounds mean RMSD: isoorientin (0.72 Å ± 0.32), lupeol (mean 0.38 Å ± 0.08), and andrographolide (1.09 Å ± 0.49). A similar strong agreement on systems stability was unraveled by MMGB/PBSA that found net binding net ~ −20 kcal/mol for the complexes dominated by van der Waal interaction energy.

Conclusion:

It has been predicted that proposing potential IL-6 inhibitors with less side effects can help critical COVID-19 patients because it may control the cytokine storm, a major responsible factor of its pathogenesis. In this study, 3 potential phytocompounds have been proposed to have inhibitory effect on IL-6 that can be tested as potential therapeutic options against SARS-CoV-2.