bluuebunny/crossref_metadata_2025 huggingface dataset:
Robot Arm Control Using Hybrid intelligent
Authors: Elmenfy Twfiq H. , Mosa Mona Mohammed , Abdelsalam Samah
Published: November 2023

The design of a fuzzy logic control suffers from select parameters of the membership functions, scaling factors, defuzzification action, Inference engine and base rules. speaking generally, such prosecutions are executed by traditionally techniques which do not assure an robust fuzzy control system design. There are various techniques introduced in literatures that used Genetic Algorithms to optimize a fuzzy logic control component. . In this paper, the suggested control law consists of Fuzzy Logic Control (FLC) tuning via Geneticn Algorithm (GA). The FLC used because it is efficient tools for control of nonlinear and uncertain parameters systems. GA is mainly presented to find a simultaneous near optimum design of the membership functions, scaling factors, defuzzification Method, Inference engine and control base rules. GA with different fitness functions in a form of the cumulative response error which are widely used as an efficient optimization technique. This paper also introduce a new methodology with new multi-objective function to improve fuzzy control parameters based on Genetic Algorithm techniques. The dynamic model of the robot manipulator its done by differential equations, these equations are hardly nonlinear, parameters uncertainty and time varying with multiple input and multiple output (MIMO).The manipulator robot and the fuzzy genetic control are modeled in MATLAB SIMULINK; the manipulator robot model driven nonlinear controller to draw a circle in the space with and without parameters uncertainties. The proposed techniques showed that the proposed fuzzy controller gives superior response in the output performance. When the parameter uncertainties including in the system, given satisfactory response.
Civil protection of the population: problems of state administration
Authors: Musienko Tamara , Lukin Vladimir
Published: November 2023

The problem of studying the domestic historical experience of public administration in creating a system for ensuring security and civil protection has been updated, taking into account the modern geopolitical and military confrontation between the united West and the Russian Federation.

The content of the activities of the state administration bodies of the Russian Empire to strengthen the army, the defense of the country and the protection of the population is revealed, the unsystematic nature, delay and errors in solving these issues, as well as the degree of influence of the low efficiency of managerial decisions on the loss of imperial statehood, are revealed. Attention is focused on the danger of German influence on management decisions in the Russian Empire and the "fifth column" in modern Russia.

An express analysis of the implementation of the idea of "universal arming of the people" in the first years of Soviet power and the legalization of this idea in the Constitutions of the RSFSR were carried out; organizational and managerial work of the new authorities on military training of the country's population in the Vsevobuch system.

The insufficient degree of modern research in this area of state activity is revealed. The necessity of using the historical experience of the period of the First World War and the Civil War, both negative and positive, is substantiated.
Efficiency of the Combined Photodynamic Therapy with Cisplatin in the Treatment of B16 Melanoma in C57BL/6 Mice
Authors: Круглов Степан Сергеевич , Панченко Андрей Владимирович , Нехаева Татьяна Леонидовна , Тындык Маргарита Леонидовна , Федорос Елена Ивановна
Published: November 2023

Введение. Фотодинамическая терапия — один из современных методов лечения опухолевых и предопухолевых заболеваний. Данный метод имеет ряд ограничений, одним из направлений преодоления которых может быть его комбинирование с химиотерапевтическими противоопухолевыми средствами.
Цель исследования. Изучить возможности сочетания фотодинамической терапии с цисплатином на модели меланомы B16 у мышей линии C57BL/6.
Материалы и методы. Нами проведена оценка возможности сочетания фотодинамического противоопухолевого воздействия с использованием фотосенсибилизатора хлоринового ряда Радахлорина® и цисплатина на модели меланомы B16 у мышей линии C57BL/6. Фотоактивацию проводили лазерным излучением с длиной волны 662 нм с дозой облучения 300 Дж/см2.
Результаты. Торможение роста опухоли по сравнению с контрольной группой было максимальным на 7 сутки и составило 42 % в группе фотодинамической терапии (р < 0,01), 60 % в группе с введением цисплатина за 30 минут до фотодинамической терапии (р < 0,001), 57 % в группе с введением цисплатина через 24 часа после фотодинамической терапии (р < 0,001) и 31 % (р < 0,05) в группе с введением только цисплатина. Средняя продолжительность жизни животных до достижения опухолью объема 4 см3 составила 9,8 ± 0,6 суток в контроле, 9,3 ± 1,7 суток в группе с фотодинамической терапией (р = 0,9829), 8,9 ± 0,8 суток в группе, получавшей цисплатин (р = 0,3247), 10,3 ± 2,8 суток при введении цисплатина за 30 минут до фотодинамической терапии (р = 0,1309) и 12,7 ± 2,1 суток при введении цисплатина через 24 часа после проведения фотодинамической терапии (р = 0,0214).
Заключение. Комбинированное применение фотодинамической терапии Радахлорином® с введением цисплатина на модели меланомы B16 позволило получить аддитивный противоопухолевый эффект и увеличение продолжительности жизни.
Morphogenesis and Pathological Changes of Additional (Aberrant) Mammary Gland in Humans
Authors: Мнихович Максим Валерьевич , Ененков Никита Васильевич , Ерофеева Людмила Михайловна , Безуглова Татьяна Васильевна , Ширипенко Иван Александрович
Published: November 2023

Дополнительные молочные железы развиваются в результате неполной регрессии эмбриональных молочных линий не только у женщин, но и у мужчин, располагаются преимущественно в подмышечной впадине. Эти железы могут не иметь внешних проявлений (наличие соска и ареолы). Симптоматически проявляются циклическими болями и отеком во время менструации и беременности, обусловленными гормональными перестройками. Дополнительные молочные железы могут претерпевать и доброкачественные, и злокачественные патологические изменения, также как обычные анатомические молочные железы. В связи с низкой частотой встречаемости дополнительной молочной железы (у 2–6 % женщин) и ее патологических изменений, большая часть мировой литературы включает описания отдельных клинических случаев. Поэтому цель настоящего обзора: рассмотреть структуру, нормальный морфогенез и патологические изменения дополнительной молочной железы. Для подготовки обзора проведен поиск литературы по базам данных Scopus, Web of Science, Medline, PubMed, CyberLeninka, РИНЦ и CNKI. При анализе использованы отечественные и зарубежные научные и клинические исследования, индексируемые в базах данных Scopus, Web of Science, PubMed, из них 31 % опубликованны за последние 5 лет. Использовано 72 источника для написания данного литературного обзора.
Importancia de los Grupos de Apoyo de salud en pacientes Oncológicos
Authors: Ramírez López Natalia
Published: November 2023

El impacto de la enfermedad, no es solamente individual; en la afectación de la persona enferma hay que sumarle el efecto que el cáncer produce en el entorno familiar. (Yman, 2019) Dentro de este mismo contexto, María Carmen Terol, (1999) manifiesta que, el inicio y proceso de esta enfermedad desencadena una serie de problemas físicos, emocionales, y comportamentales que influyen en la adaptación y ajuste de estos pacientes. (Terol, 1999). En la actualidad, los objetivos del cuidado del paciente de cáncer incluyen tanto los cuidados médicos como la atención hacia determinadas áreas de impacto social y psicológico. La incertidumbre y la amenaza a la vida ante una enfermedad como el cáncer le confiere unas características especiales que incrementan las necesidades de apoyo (Hegelson y Cohen, 1996). De ahí, que, la formación de clubes de apoyo permite que los pacientes puedan enfrentar la ansiedad y la depresión, y dentro del mismo, se visualiza, la gran importancia del área de enfermería en los cuidados de los pacientes oncológicos. El objetivo del trabajo centra su interés en analizar los efectos del grupo de apoyo sobre la salud en pacientes oncológicos de la ciudad de Pilar. Por ende, se ve la necesidad de realizar un estudio de investigación en la Unidad de Salud Familiar del Barrio Obrero, donde se ha conformado un Club de apoyo para pacientes oncológicos y sus familiares. El trabajo se encuadra dentro de la modalidad de artículo científico. Corresponde a un tipo de estudio descriptivo, utilizando el método cualitativo y de corte transversal. Como técnica de recolección de datos se implementará la entrevista, el análisis documental y el cuestionario. Los resultados de este estudio servirán para que los profesionales de la salud, específicamente las enfermeras establezcan estrategias de cuidado integral y humanizado, donde se tenga en cuenta el aspecto emocional, instrumental e informativo en el cuidado del paciente, incluyendo a la familia de los mismos, otorgando pautas de cómo apoyarlos.
Meningkatkan Kualitas Keluarga Melalui Komunikasi Efektif di Era Digital
Authors: Indrawati Erdina , Yulius Yudi , Rahayu Anizar , Syafrida Nasution Evi , Sintawati Sri
Published: November 2023

Penggunaan ponsel pintar di kalangan orang tua meningkat tajam, karena mereka mencariketerhubungan dengan pasangan, teman, dan pekerjaan selama masa-masa sebagai orang tua yang terkadang tidak terhubung secara sosial. Karena semakin banyak orang tua yang menggunakan ponsel pintar saat berinteraksi dengan anak-anak mereka, semakin banyak penelitian mengenai implikasi penggunaan ponsel pintar orang tua terhadap interaksi orang tua-anak. Berdasarkan hasil penelitian yang telah ada, terlihat bahwa penggunaan ponsel dapat memberikan dampak positif dan negatif bagi keluarga. Oleh karena itu, perlu adanya peningkatan kemampuan dan pemahaman orang tua dalam penggunaan ponsel dalam keluarga sehingga dampak negatif yang mungkin muncul dapat dicegah. Untuk mengatasi permasalahan tersebut telah dilaksanakan kegiatan pengabdian kepada masyarakat di Kejaksaan Negeri Depok dengan metode penyuluhan, yang dilaksanakan dalam beberapa tahap. Pertama analisis situasi, kedua penyusunan materi pengabdian, selanjutnya melakukan perijinan dan koordinasi dengan mitra terkait pelaksanaan pengabdian, melakukan kegiatan penyuluhan dan evaluasi. Hasildari kegiatan ini adalah peningkatan pengetahuan dan pemahaman orang tua tentang penggunaan ponsel pintar dalam berkomunikasi dengan anggota keluarga.

 

Smartphone use among parents is increasing sharply, as they seek connectedness with partners, friends, and  work during the sometimes socially disconnected time of parenthood. As more parents use smartphones when interacting with their children, there is increasing research on the implications of parental smartphone use on parent-child interactions. Based on the results of existing research, it appears that cellphone use can have both positive and negative impacts on the family. Therefore, it is necessary to increase parents' ability and understanding of using cell phones in the family so that negative impacts that may arise can be prevented. To overcome this problem, community service activities have been carried out at the Depok District Prosecutor'sOffice using the counseling method, which is carried out in several stages. First, analyze the situation, second, prepare service materials, then carry out permits and coordinate with partners regarding the implementation of service, and carry out outreach and evaluation activities. The result of this activity is an increase in parents' knowledge and understanding of the use of smartphones in communicating with family members.
Pembinaan Pelaksanaan Pembelajaran Akuntansi Untuk Melatih Siswa SMK Negeri 3 Depok Siap Kerja Dengan Teknologi Tepat Guna
Authors: Widyastuti Shinta , Arieftiara Dianwicaksih , Masripah
Published: November 2023

Pemerintah Pusat ataupun Daerah saat ini sangat peduli dengan metode pembelajaran siswa,tidak terkecuali di tingkat SMK. Pemerintah Daerah menginginkan siswa SMK menggunakanteknologi tepat guna agar siswa siap kerja. Pemerintah Pusat pun mencanangkan kurikulum merdeka agar proses belajar mengajar tidak terpaku pada tatap muka dikelas tetapi bisa melalui metode/media pembelajaran lain yang lebih fleksibel, seperti video pembelajaran. Teknologi tepat guna pada jurusan akuntansi berkaitan dengan software akuntansi yang saat ini digunakan oleh perusahaan di Indonesia. Software-software tersebut belum tentu dimiliki oleh sekolah terutama SMK Negeri 3 Depok karena kendala biaya. Melalui kegiatan Pengabdian kepada Masyarakat ini, tim UPNVJ mengadakan 2 kegiatan yang terkait kurikulum Merdeka. Pertama adalah kegiatan sharing knowledge terkait Kurikulum Merdeka dan yang kedua adalah pendampingan pembuatan video pembelajaran tentang penggunaan Aplikasi Accurate online.

 

Government give attention about learning methode for vocational school. Government wantstudents in vocational school use appropriate technology to encounter working world. Independent Curriculum is declared to fulfill Government’s goals. In Independent Curriculum, students are not only get offline learning in class room but also get online learning. Students can study any where from learning video. Appropriate technology in accounting study program is a about accounting software like Accurate Online. SMK Negeri 3 Depok do not have Accurate Online Application because of fund. UPNVJ team perform 2 activities, that is sharing knowledge about independent curriculum and accompaniment to produce Accurate Online Learning Video.
“RELIGION AND PHILOSOPHY OF HINDUISM”
Authors: Mishra Dr. Harishchandra
Published: November 2023

This research Article attempts to provide an understanding of the concept of Religion in general and to describe the key points of the Philosophy of Hinduism in particular. The word Dharma is derived from the root ‘dhr’ to hold or support" and refers to a regularity of conduct and action which holds together and supports social life. The Dharma which forms the central element of Hinduism is essentially social, old social customs and habits and ideals which have come down from ancient times and will admit of no change. These customs bear the stamp of approval of the sages of old who were in contact with the gods and super-human powers, and are thereby given a super-human, religious sanction and have eternal validity. Here, an attempt is also made to describe Hinduism or Indian religion as a cultural tradition. Yogendra Singh in his book ‘modernization of Indian traditions, 1973’ identified four major cultural traditions of Indian civilizations as Hierarchy, Holism, Continuity and Transcendence. This paper is an attempt to outline the essence of the Hinduism. Hinduism is a religion of Indian origin and, not merely followed by majority population of India and Nepal but also followed by many people in countries of America, Europe, Africa, south and south-east Asia and so on. Indeed, it is world’s religion.
DEVELOPING COMPETENCIES FOR EDUCATION FOR SUSTAINABLE DEVELOPMENT [ESD] USING VIDEO CONTENT ANALYSIS AS AN EXPERIENTIAL LEARNING PRACTICE IN THE COVID-19 DISTANCE LEARNING
Authors: Kaur Dr. Paramjit , Sharma Prof. Saroj , Ahuja Dr. Amit
Published: November 2023

Education for Sustainable development (ESD) is established as single most important method of achieving Sustainable Development Goals (SDGs) in the years to come. According to UNESCO, there are five components of ESD competencies: Knowledge, Skills, Perspectives, Behaviour and Values. Experiential learning can be an effective pedagogical technique. This is primarily because of its learner-centric character and scope of closely simulating real life without the risks of actually being involved in it. This research was aimed at exploring the potential of video content analysis as an educational practice for ESD in COVID-19 Distance Learning mode in classrooms of an urban private school of India. It explored ESD themes and the pedagogy that can stimulate students’ active participation. The setting provided a problem-based and incorporated reflection and immediate feedback. This facilitated learners to collaborate and develop unbiased perspectives, learn to critically reflect on social justice issues and appreciate diverse viewpoints. It provides a sense of connectedness and belongingness to community.
GESTURE RECOGNITION OF MACHINE LEARNING AND CONVOLUTIONAL NEURAL NETWORK METHODS FOR KAZAKH SIGN LANGUAGE
Authors: Mukhanov Samat , Uskenbayeva Raissa , Young Im Cho  , Kabyl Dauren , Les Nurzhan , Amangeldi Maqsat
Published: November 2023

Recently, there has been a growing interest in machine learning and neural networks among the public, largely due to advancements in technology which have led to improved methods of computer recognition of objects, sounds, texts, and other data types. As a result, human-computer interactions are becoming more natural and comprehensible to the average person. The progress in computer vision has enabled the use of increasingly sophisticated models for object recognition in images and videos, which can also be applied to recognize hand gestures. In this research, popular hand gesture recognition models, such as the Convolutional Neural Network (CNN), Long Short-Term Memory (LSTM), and Support Vector Machine (SVM) were examined. These models vary in their approaches, processing time, and training data size. The important feature of this research work is the use of various machine learning algorithms and methods such as CNN, LSTM, and SVM. Experiments showed different results when training neural networks for sign language recognition in the Kazakh sign language based on the dactyl alphabet. This article provides a detailed description of each method, their respective purposes, and effectiveness in terms of performance and training. Numerous experimental results were recorded in a table, demonstrating the accuracy of recognizing each gesture. Additionally, specific hand gestures were isolated for testing in front of the camera to recognize the gesture and display the result on the screen. An important feature was the use of mathematical formulas and functions to explain the working principle of the machine learning algorithm, as well as the logical scheme and structure of the LSTM algorithm.
A MATHEMATICAL MODEL FOR AN AUTOMATED SYSTEM OF MEDICAL DIAGNOSTICS
Authors: Myrzakerimova Alua , Kolesnikova Kateryna , Nurmaganbetova Mugulsum
Published: November 2023

One of the primary focuses of the Republic of Kazakhstan concerning sustainable and stable improvements in the well-being of its population is the advancement of the healthcare sector. A mathematical model for an automated medical diagnostics system integrates machine learning algorithms, statistical models, and decision trees to analyze patient data and facilitate accurate diagnoses. This model enables healthcare professionals to enhance the efficiency and reliability of medical diagnostics by leveraging advanced computational techniques.In diagnosing diseases, the differential diagnosis between primary biliary cirrhosis of the liver and active hepatitis with cholestatic syndrome poses a challenge due to their overlapping symptoms. Both conditions exhibit jaundice, pruritus, fatigue, and hepatomegaly. However, distinguishing features based on clinical and laboratory observations can aid in accurate differentiation between the two states. These distinguishing features can be incorporated by developing a mathematical model for diagnosing diseases, enabling precise identification and guiding appropriate treatment strategies.

Predicting the progression of diseases is a crucial aspect of healthcare, enabling personalized interventions and improved patient outcomes. A mathematical approach can facilitate this prediction by monitoring changes in diagnostic results aligned with the severity of symptoms, which inherently vary over the observation period. By employing mathematical modeling techniques, healthcare professionals gain valuable insights into disease progression, supporting informed decision-making and tailored treatments.

In conclusion, developing a mathematical model for an automated medical diagnostics system, incorporating machine learning algorithms, statistical models, and decision trees, significantly contributes to healthcare. These models enhance the accuracy, efficiency, and personalization of medical diagnoses. Additionally, mathematical models aid in the differential diagnosis of challenging conditions and provide predictions regarding disease progression, ultimately benefiting patient care and treatment outcomes.
responsabilidad civil de los padres por no vacunación de sus hijos menores
Authors: Barceló Doménech Javier
Published: November 2023

El trabajo analiza el régimen jurídico de la vacunación en España, los conflictos surgidos por el desacuerdo de los padres a la hora de decidir sobre la vacunación de sus hijos menores y la posibilidad de ejercitar una acción de responsabilidad en caso de daño a la salud de esos hijos
Soft-sensing modeling of mother liquor concentration in the evaporation process based on reduced robust least-squares support-vector machine
Authors: Qian Xiaoshan , Xu Lisha , Yuan Xinmei
Published: November 2023

The evaporation process is vital in alumina production, with mother liquor concentration serving as a critical control parameter. To address the challenge of online detection, we propose the introduction of a soft measurement strategy. First, due to the significant fluctuations in the production process variables and inter-variable coupling, comprehensive grey correlation analysis and kernel principal component analysis are employed to reduce the input dimension and computational complexity of the data, enhancing the efficiency of the soft sensing model. The reduced robust least-squares support-vector machine (LSSVM), with its commendable predictive performance, is used for modeling and predicting the principal components. Concurrently, an improved Pattern Search-Differential Evolution (PS-DE) algorithm is proposed for optimizing the pivotal parameters of the LSSVM network. Lastly, on-site industrial data validation indicates that the new model offers superior tracking capabilities and heightened accuracy. It is deemed aptly suitable for the online detection of mother liquor concentration.
Hiroshima selon Keiji Nakazawa : dans l’ombre de la bombe
Authors: Capiau Brecht
Published: November 2023

LIVRE : Le 8 juillet 2022, l’assassinat de l’ancien Premier ministre japonais Shinzo Abe secoue le monde entier… et surtout les Japonais. D’après une étude de l’Institute for Health Metrics and Évaluation, le taux d’homicides par armes à feu ne s’élève pourtant qu’à 0,02 victime pour 100 000 habitants au pays du Soleil levant. Par comparaison, ce chiffre monte à 4,12 aux États-Unis, plaçant cette nation en tête d’un bien sombre classement. Le pacifisme qui caractérise la politique intérieure et extérieure nipponne depuis la fin de la Seconde Guerre mondiale a très certainement contribué à ce score historiquement bas, tout comme la culture populaire japonaise. Gen d’Hiroshima, chronique antiguerre de plus de 2 500 pages livrée par le mangaka Keiji Nakazawa, est sans l’ombre d’un doute l’ultime témoignage de la résistance japonaise face à tout ce qui se rapporte à la violence et à la militarisation
La lecture comme support pédagogique pour l’apprentissage de la Shoah dans l’enseignement secondaire en Fédération Wallonie‑Bruxelles
Authors: Lambert Anne
Published: November 2023

ENQUÊTE : L’enseignement de la Shoah a évolué progressivement, marquant la prise de conscience de l’importance de transmettre cette période de l’histoire aux jeunes générations. L’école est ainsi perçue par les enseignants comme le moyen principal de transmission de la Shoah en Fédération Wallonie-Bruxelles (FWB). Ils ont la liberté d’approfondir certains sujets et d’en survoler d’autres1. Floriane Schneider et Iannis Roder2 distinguent la transmission de contenu et les méthodes pédagogiques pour construire une mémoire durable. Outre les manuels scolaires, les enseignants ont ainsi intégré d’autres outils, dont la littérature, pour encourager la réflexion, l’esprit critique et l’apprentissage. Cet article examine comment les livres peuvent être un support efficace pour l’enseignement de la Shoah. Il se base sur une enquête menée auprès des enseignants du secondaire de la FWB au premier semestre 2023 par la Fondation Auschwitz. Le rapport complet sera publié ultérieurement.
Verbreden van de horizon, inclusief werken voor jongeren en de rol van verhalenvertellers bij het overbrengen van de herinnering aan de Holocaust
Authors: Gyssels Kathleen
Published: November 2023

En France et en Belgique, les recherches sur la corrélation entre littérature de jeunesse et la Shoah sont rares, contrairement à l’attention phénoménale en Amérique (tout le monde connaît Maus d’Art Spiegelman) et dans d’autres pays anglophones. Pourtant, les livres pour enfants qui dépeignent la Shoah en mots et en images n’ont cessé de prendre de l’ampleur dans la France d’après-guerre et en Belgique. Alors que la critique et la recherche littéraires semblent encore balbutiantes, ce dossier montrera que l’analyse critique de ce corpus est d’une grande pertinence pour l’avenir.
Schrijfpad, rookpad
Authors: Brami Élisabeth
Published: November 2023

“Zwijgen is verboden, spreken is onmogelijk,” zegt Elie Wiesel aan Jorge Semprun. Dié antwoordt hem: “Hoe meer ik schrijf, hoe meer de herinnering bij me terugkomt.” Élisabeth Brami analyseert haar eigen romans en albums, in een poging de vraag te beantwoorden of het al dan niet mogelijk is om ervaringen van de Holocaust door te geven, zij het in geschreven vorm of anderszins.
An Observational Study of Factors affecting CA125 Levels in Premenopausal Women
Authors: Balachandran Amrita , Nayak S Radhakrishna
Published: November 2023

Background:

CA125 levels show a variation in premenopausal women during the menstrual cycle. Moreover, various modifiable and non-modifiable factors affect its value which needs to be taken into account while interpreting the results. The study was done with an objective (1) to determine differences in CA125 levels during the mid-cycle and menstrual phase of menstruation and (2) to determine the factors (demographic and clinical) that may affect CA125 values.

Materials and Methods:

An observational study was conducted from December 2017 to May 2019. Women of reproductive age group of 15–45 years with regular menstrual cycles were included in the study. The CA125 levels were compared among mid-cycle values and values during menstruation. A mean of the values was taken, and factors affecting it were determined by regression analysis. P < 0.05 was considered statistically significant.

Results:

The mean age of the patients was 28.71 ± 6.14 years. The median day of sample collection during menses was day 2 and during mid-cycle was day 14. Compared to mid-cycle CA125 values, values during menses were significantly higher (24.74 ± 17.43 vs. 12.39 ± 7.3, P < 0.0001) with a mean difference of 12.35 ± 15.04. Multivariate regression analysis showed that days of menses (beta coefficient 3.49, P = 0.0001) and regular caffeine consumption (beta coefficient 7.074, P = 0.007) were significant independent positive risk factors of CA125 levels.

Conclusion:

In conclusion, CA125 levels are significantly higher during menstruation as compared to mid-cycle values in premenopausal women. The significant factors leading to higher CA125 levels are days of menses and caffeine consumption.
Differential Gene Expressions of CALM1, PSMD6, and AK124742 Long Noncoding RNA in Cumulus Cells from Polycystic Ovary Syndrome Patients versus Normal Control Women
Authors: Akbari Ali , Aboutorabi Roshanak , Kazemi Mohammad , Borzouie Zahra , Feizi Awat , Naghshineh Elham , Mostafavi Fatemesadat
Published: November 2023

Background:

One of the well-known causes of subfertility is polycystic ovary syndrome (PCOS). Genetic components play a critical role in the etiology of PCOS. The recognition of differentially expressed genes in PCOS patients might provide a better understanding of the pathophysiology of this syndrome and paves the way for novel therapeutics. Gene expression profiles in cumulus cells (CCs) could be used as biological criteria for embryo competence and their analysis might lead to important molecular information about embryo quality. CALM1, PSMD6, and AK124742 are three well-known genes associated with embryo development. Therefore, the objective of this study was to compare the expression of CALM1, PSMD6, and AK124742 genes in the CCs of infertile PCOS patients with their expression in the CCs of the donor fertile group.

Materials and Methods:

CCs were collected from the follicular fluid of 33 patients with PCOS as the experimental group and 33 cumulus donor women who were referred to the infertility center for egg donation as the control group. CCs were frozen until genetic testing. The expression of CALM1, PSMD6, and AK124742 genes was detected by real-time polymerase chain reaction.

Results:

CALM1 and AK124742 gene expressions significantly increased (CALM1 P = 0.003) (AK124742 P = 0.000) and PSMD6 expression significantly decreased (P = 0.002) in the PCOS group compared to the cumulus donor (control) group.

Conclusion:

Therefore, our research findings suggest that the potential impact of Polycystic Ovary Syndrome (PCOS) on fertility could be attributed to modifications in the expression levels of genes that affect the reproductive.
Diagnostic Significance of Hypomethylated IGFBP3 and TWIST1 Genes in Patients with Colorectal Cancer
Authors: Shalmashi Hooman , Safaei Sahar , Zarredar Habib , Asvadi Kermani Touraj , Hashemzadeh Shahryar , Mehdi Navaz Abdolreza
Published: November 2023

Background:

Colorectal cancer (CRC) has been often the main reason for dying worldwide. Many factors are implicated in the progress of colorectal carcinoma, one of the chiefs of which is DNA methylation. Insulin-like growth factor-binding protein 3 (IGFBP3) and twist homolog 1 (TWIST1) genes have already been studied and are potential biomarkers for early colorectal diagnosis. Therefore, we designed this research to assess the levels of methylation of these genes in stool specimens of patients with CRC.

Materials and Methods:

A whole of 80 specimens containing 40 stool specimens from CRC patients and 40 specimens from healthy individuals as a control group was investigated. DNA was extracted using the bisulfate method and methylation of the candidate genes was assessed using methylation-sensitive high-resolution melting method. Differences in the methylation levels between CRC patients and controls were assessed by statistical analysis.

Results:

Our study showed significant hypomethylation in both IGFBP3 and TWIST1 promoters in patients’ samples compared with normal individuals and notably the promoter hypomethylation found in these genes appeared to occur simultaneously (P < 0.0001 and P < 0.0025, respectively). Meantime, hypomethylation of these genes had not any significant connection with medical results.

Conclusion:

Our results propose that the IGFBP3 and TWIST1 genes’ methylation status can serve as potential biomarkers for early CRC diagnosis. However, more studies are still necessary to better appreciate the methylation pattern of these two genes in CRC and to prove their effects on protein levels.
Abnormal Chest Skiagram in a Normal Individual a Case Report on Orphan Lung Disease – Pulmonary Alveolar Microlithiasis
Authors: Kumar D. Suresh , Gokul K.
Published: November 2023

Pulmonary alveolar microlithiasis (PAM) is a rare inherited disorder of sodium phosphate cotransporter which causes accumulation of microliths in alveoli. This is a case report of a 46-year-old female, came for surgical fitness for laparoscopic cholecystectomy with abnormal chest skiagram. Chest skiagram showed typical sand storm appearance. Since the patient had no respiratory complaints, high-resolution computed tomography chest was taken which showed diffuse micronodular calcifications suggestive of PAM.
Post-COVID-19 Pneumonia Complicated with Guillain–Barre Syndrome
Authors: Muthulakshmi S. , Murthy K. Anupama
Published: November 2023

Guillain–Barré syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy that is often related to a previous infectious exposure. GBS emerged as a potentially serious complication of COVID-19 infection. Here, we present the case of a 64-year-old female who presented to us with worsening respiratory failure and progressive flaccid symmetrical sensorimotor neuropathy following COVID infection. She was diagnosed to have GBS as post-COVID complication. Hence, started on intravenous immunoglobulin infusion following which she had improvement in respiratory failure and prevented from intubation and mechanical ventilation.
Drug-Induced Interstitial Pneumonitis in a Case of Breast Malignancy
Authors: Murugesan Hema , Kumaran Sugumar , Selvam Rithika , Pandian Venkatakrishnaraj , Viswanathan Vinod Kumar
Published: November 2023

Drugs used in the treatment of diseases including malignancy are known to cause various lung injuries, including interstitial pneumonitis. With increasing incidence of malignancies and advent of newer and newer chemotherapy and immunological treatments, it is prudent on the part of the pulmonologist to identify such complications at the earliest so that appropriate treatment can be initiated and reduce morbidity and mortality due to such causes. Herewith is presented a case of a patient with invasive ductal carcinoma of the breast who developed interstitial pneumonitis after 2 weeks of treatment with docetaxel and trastuzumab and was managed successfully.
Witten–Reshetikhin–Turaev invariants for 3-manifolds from Lagrangian intersections in configuration spaces
Authors: Anghel Cristina Ana-Maria
Published: November 2023

In this paper, we construct a topological model for the Witten–Reshetikhin–Turaev invariants for

3

-manifolds coming from the quantum group

U_q(\mathrm{sl}(2))

, as graded intersection pairings of homology classes in configuration spaces. More precisely, for a fixed level

\mathcal{N}\in \mathbb{N}

, we show that the level

\mathcal{N}

WRT invariant for a

3

-manifold is a state sum of Lagrangian intersections in a covering of a fixed configuration space in the punctured disc. This model brings a new perspective on the structure of the level

\mathcal{N}

Witten–Reshetikhin–Turaev invariant, showing that it is completely encoded by the intersection points between certain Lagrangian submanifolds in a fixed configuration space, with additional gradings which come from a particular choice of a local system. This formula provides a new framework for investigating the open question about categorifications of the WRT invariants.
Sonographic evaluation of maternal blood loss after childbirth using postpartum inferior vena cava diameter among parturients in Kano Metropolis, Nigeria
Authors: Saleh A. A. , Ohagwu C. C. , Okonkwo C. O. , Sidi M. , Masur U.
Published: November 2023

Postpartum hemorrhage has been a major cause of maternal morbidity and mortality globally every year. Sonographic measurement of inferior vena cava diameter is a cheap, safe, non-invasive method and an indicator of blood loss after childbirth. The study was aimed to establish normal range values of postpartum inferior vena cava (IVC) among parturients in Kano metropolis, Nigeria. A prospective and longitudinal study from September, 2021 to September, 2022 was adopted and a minimum sample size of 210 measurements of IVC intraluminal diameter was calculated for the study using G Power sample size software. The sample comprised of two sets measurements obtained from 105 parturients before delivery and after delivery. The maternal heart rate and systolic blood pressure were measured. Blood samples from all subjects were collected. The data was analyzed using IBM Statistical Software. The range value of IVC diameter on inspiration of the subjects before childbirth was 13.2 mm – 20.3 mm, after childbirth was 9.1 mm – 16.7 mm. The IVC diameter range on expiration before childbirth was 17.3 mm – 24.8 mm, after childbirth was 12.6 mm – 21.4 mm. The Packed Cell Volume (PCV) range of the subjects before childbirth was 35% – 40%, after childbirth was 18% – 33%. The heart rate before childbirth was 64 bpm – 100 bpm, after childbirth was 70 bpm – 100 bpm. The systolic blood pressure before childbirth was 110 mmHg – 120 mmHg, after childbirth was 90 mmHg – 120 mmHg. The shock index before childbirth was 0.5 – 0.9 and after childbirth was 0.6 – 0.9. A statistical significant (p<0.001) difference in IVC was observed. Furthermore, a statistical significant (p<0.001) difference was obtained in PCV, maternal heart rate, systolic blood pressure and shock index. There was a statistical significant strong positive correlation between IVC and PCV during inspiration and expiration before and after childbirth.
Prevalence of antibiotic-resistant gram-negative bacteria among patients with urinary tract infection at a facility in Ado Ekiti, Ekiti-State, Nigeria
Authors: Ajayi A. O.
Published: November 2023

Urinary Tract Infections (UTIs) constitute a huge public health burden especially in developing countries. This study was carried out to determine the current incidence of antibiotic resistance among Gram-negative bacteria recovered from urine of patients with UTI. This study used a cohort study design wherein one hundred and twenty one (121) mid-stream urine samples were collected and cultured onto sterile Cysteine Lactose Electrolyte Deficient medium (CLED) and MacConkey agar plates. All bacteria recovered were tested for resistance to the selected antibiotics as follows: ceftazidime (30 μg), ceftriaxone (30 μg), gentamicin (1 0μg), ampicillin (10 μg), meropenem (10 μg), ertapenem (10 μg), tetracycline (30 μg), norfloxacin (10 μg) and pefloxacin (5 μg). Twenty (20) isolates were chosen for detection of extended spectrum beta-lactamase producers using the double disk synergy test (DDST). All the bacteria were tested for biofilm production and haemolysis. Among the one hundred and twenty-one (121) mid-stream urine samples collected from patients, forty-six (46) samples grew significant bacteria. The bacteria recovered were Klebsiella pneumonia17 (37.0%), Klebsiella oxytoca 2 (4.3%), Escherichia coli (32.6%) and Proteus mirabilis (26.0%). Overall, the bacteria showed the highest resistance to pefloxacin (97.8%) and least resistance to meropenem (34.7%). The bacteria also showed high multiple resistance. All the bacteria subjected to DDST were confirmed as extended-spectrum beta-lactamase ESBL producers. Forty (43.6%) bacteria were designated as strong biofilm producers while 17.4 % bacteria showed hemolysis. The findings obtained in this study have ramifications for clinical management of UTI and public health public health in general. There should be strict enforcement of antibiotic stewardship.
Optimal selection of cluster head in wireless sensor networks using particle swarm optimization (PSO)
Authors: Zakariyya Aliyu , Iliyasu Umar , Jamilu Bashir Ahmad
Published: November 2023

In a wide range of applications, such as the military, healthcare, and environmental monitoring, wireless sensor networks (WSNs) have emerged as a key player. Cluster-based WSNs are a viable method for enhancing the life of the sensor network. Choosing the proper cluster head for wireless sensor networks (WSNs) is a key undertaking that affects the network's performance. Current approaches for selecting the cluster head have a number of drawbacks, such as nodes dying too quickly, uneven energy utilization, and shorter network lifespan. Additionally, conventional techniques like fixed Cluster Head and randomized Clustering are ineffective at extending the network lifetime. In the proposed method, Particle swarm optimization was used to create an optimal cluster head selection that addresses the problem of intra-cluster communication and lowers SN energy consumption. The simulation result shows that the performance improvement of the developed algorithm PSO in terms of network lifetime is 10% against Improved Cuckoo Search Algorithm (ICSA) and 25% against Hybrid Crow Search Algorithm (HCSA), energy consumption is 15% against ICSA and 20% against HCSA, and number of alive node is 4% against ICSA and 6% against HCSA respectively. Therefore, our developed algorithm PSO outperforms ICSA and HCSA in terms of the aforementioned parameters.
Multi-criteria analysis of different land-use activities on groundwater resources in Maiduguri, Borno State
Authors: Bakari Ali
Published: November 2023

Land use and their related anthropogenic activities are likely to continue to impact shallow groundwater quality at different scales. Multi-criteria analysis (MCA) is a framework for evaluating decision options against multiple criteria. This study employed the Simple Multi-Attribute Rating Technique (SMART) methodology in ranking the different land-use activities based on their adverse effects on groundwater quality. In this respect, the strategic stakeholders engaged in this study were allowed to prioritise these activities based on the magnitude of their negative effect on the groundwater resources of the study area. The stakeholders' ranking shows that the residential area is the principal activity (44.7%) that has an impact on groundwater resources in Maiduguri. This is followed by agricultural land and forested areas with negative impacts in the range of 9% and 2.18%, respectively. Geographic Information System data was obtained from secondary data sources to show the impact of different land uses in the study area This study will be helpful to policymakers and decision-makers in adopting mitigation strategies that will provide solutions to the negative effects of groundwater contamination in Borno State.
An automatic door lock security system based on convolutional neural network
Authors: Esan Adebimpe , Okomba Nnamdi , Sobowale Adedayo , Adebiyi Tomilayo , Jooda Bunmi , Peace Ajala
Published: November 2023

Door lock security is important because it prevents intruders or unauthorized individuals from entering our homes or offices. Previous door lock security systems based on password, radio frequency identification and facial recognition are unreliable. Therefore, this project developed an automatic door lock security system using Convolutional Neural Network. Fifty faces of home owners were captured and trained using CNN. The system was tested at different distances and lightning condition and evaluated using accuracy, precision and f1 score. Results show that the developed system is 91.67% accurate. However, it is recommended that future work considers increasing dataset for model training to obtain more accurate results.
Ultrasonographic correlation of placental thickness with some foetal biometry in seemingly normal singleton pregnancies in Taraba State, Nigeria
Authors: Yakubu Adamu , Ya’u Anas , Buba Emmanuel , Fatima Ibrahim Zahra
Published: November 2023

An accurate assessment of the gestational age (G.A) and evaluation of foetal growth is essential to antenatal care. GA prediction based on the sonographic foetal parameters may be the cornerstone in modern obstetrics and continues to remain an important component of the management of pregnancies. Placental thickness appears to be a promising parameter for the estimation of GA, for it tends to have a positive correlation with it. Ultrasonography helps in the assessment of the placenta and the detection of placental abnormalities using different parameters like placental thickness and volume. This study was conducted to sonographically measure the placental thickness and correlate it with some foetal biometry in apparently normal singleton pregnancies. A prospective cross-sectional design was employed for the study from March to July 2021 in Jalingo, Taraba State. A convenient sampling method was employed and included a total of 314 healthy pregnant women referred for obstetrics ultrasound scans in their 2nd and 3rd trimesters. Ultrasound scans were performed using an ultrasound system equipped with a 3.5 MHz curvilinear transducer. Findings from this study revealed an increasing trend in the values of the mean placental thickness with an increase in G.A, and the placental thickness in mm coincide almost exactly with the GA weeks, indicating there was a positive correlation between placental thickness and G.A from 14-35 weeks of gestation. However, placental thickness gradually declined from 36-40 weeks G. A, thereby, lagging behind the G.A marginally by 1-2 mm. Placental thickness cord insertion site can be used as an accurate sonographic parameter to determine the GA, especially from 14-35 weeks of gestation in apparently normal singleton pregnant women due to its statistically strong positive correlation with G.A.
Geodetic control extension at erosion prone areas using integrated CORS-GNSS in Benin City, Edo State Nigeria
Authors: Akhigbe R.A , Oladosu S. O. , Ehigiator-Irughe R.
Published: November 2023

This study addresses the imperative expansion of geodetic controls in erosion-prone areas of Benin City, with a focus on establishing controls in specific schools. Two observation campaigns were conducted on nine monumented controls with 36 baselines and another set of eight controls with 28 baselines. Data adjustments were successfully carried out using Trimble Business Centre software, at 10.00σ confidence level and 1.00% significance for the tau test in the second iteration of both campaigns. Analysis revealed varying accuracy levels among stations. Notably, stations ADLC_01, ADLC_02, and QSS_01 demonstrated a minimum latitude accuracy of 1.3 mm, while AGGS_01 and AGGS_02 showcased the highest accuracy at 1.7 mm. Similar trends were observed in longitude and height measurements. For longitude, the maximum standard deviation (3.3 mm) was recorded at ENV_101D station, while the minimum accuracy (1.7 mm) was obtained at station AGGS_01. The minimum accuracy in height (3.5 mm) was recorded at station AGGS_01, while the maximum accuracy (6.7 mm) was recorded at station SMGGS_01. These findings provide essential insights into the accuracy of geodetic controls in Benin City based on purposeful selected schools, serving as valuable information for future research, infrastructure development, and engineering projects execution
Antibacterial activities of biologically synthesized silver nanoparticles from Alcalypha wilkesenia coated with some antibiotics
Authors: Musa Mansur Murtala , Mohammed Jibril Sani , Mukhtar Umar Nasir , Him Madu Abdulkarim , Danladi Zandam Nuhu , Limangba Idirisu Jibril , Yau Makin Tasi,u
Published: November 2023

Silver nanoparticles and Acalypha wilkesiana have been shown through several lines of evidence to possess antimicrobial properties. Their activities, however, have been hampered by one or more problems ranging from poor to slow absorption, cellular degradation, development of antimicrobial resistance and unwanted oxidation in the case of the Nanoparticles. Antibiotic resistance genes have also been on a constant increase recently. This research was carried out to determine the level of efficacy of the combined complex of antibiotics coated with biologically synthesized silver Nanoparticles compared to the orthodox antibiotics individually. The silver Nanoparticles were most active on Klebsiella. pneumoniae (21mm), equal for Escherichia coli and Staphylococcus aureus (14mm) and least for P. aeroginosa (13mm). The activity of the complex on S. aureus was notably highest with the gentamycin (17mm) complex, then ofloxacin (13mm) and finally ampicillin (12mm). That of Pseudomonas aeroginosa ranged from ofloxacin (17mm) to gentamycin (16mm) and then ampicillin (14mm), while that of Escherichia coli was from gentamycin (19mm), ofloxacin (15mm) and then ampicillin (13mm). The activity of the gentamycin (18mm) and ampicillin (18mm) complexes for Klebsiella pneumoniae were found to be equal and a bit higher than that of the ampicillin (11mm) complex. The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of the selected organisms against the antibiotic complexes carried out between 2.5mg/L to 25mg/L showed no growth in all the samples. There is a need for further research to explore the pharmacokinetics and dynamics of biologically synthesized nanoparticles.