bluuebunny/crossref_metadata_2025 huggingface dataset:
Associations of advanced age with comorbidity, stage and primary subsite as contributors to mortality from colorectal cancer
Authors: Gheybi Kazzem , Buckley Elizabeth , Vitry Agnes , Roder David
Published: April 2023

Background

Although survival from colorectal cancer (CRC) has improved substantially in recent decades, people with advanced age still have a high likelihood of mortality from this disease. Nonetheless, few studies have investigated how cancer stage, subsite and comorbidities contribute collectively to poor prognosis of older people with CRC. Here, we decided to explore the association of age with mortality measures and how other variables influenced this association.

Methods

Using linkage of several administrative datasets, we investigated the risk of death among CRC cases during 2003–2014. Different models were used to explore the association of age with mortality measures and how other variables influenced this association.

Results

Our results indicated that people diagnosed at a young age and with lower comorbidity had a lower likelihood of all-cause and CRC-specific mortality. Aging had a greater association with mortality in early-stage CRC, and in rectal cancer, compared that seen with advanced-stage CRC and right colon cancer, respectively. Meanwhile, people with different levels of comorbidity were not significantly different in terms of their increased likelihood of mortality with advanced age. We also found that while most comorbidities were associated with all-cause mortality, only dementia [SHR = 1.43 (1.24–1.64)], Peptic ulcer disease [SHR = 1.12 (1.02–1.24)], kidney disease [SHR = 1.11 (1.04–1.20)] and liver disease [SHR = 1.65 (1.38–1.98)] were risk factors for CRC-specific mortality.

Conclusion

This study showed that the positive association of advanced age with mortality in CRC depended on stage and subsite of the disease. We also found only a limited number of comorbidities to be associated with CRC-specific mortality. These novel findings implicate the need for more attention on factors that cause poor prognosis in older people.
Evaluation of the impact of the COVID-19 pandemic on health service utilization in China: A study using auto-regressive integrated moving average model
Authors: Xu Rixiang , Wu Lang , Liu Yulian , Ye Yaping , Mu Tingyu , Xu Caiming , Yuan Huiling
Published: April 2023

Background

The outbreak of COVID-19 in early 2020 presented a major challenge to the healthcare system in China. This study aimed to quantitatively evaluate the impact of COVID-19 on health services utilization in China in 2020.

Methods

Health service-related data for this study were extracted from the China Health Statistical Yearbook. The Auto-Regressive Integrated Moving Average model (ARIMA) was used to forecast the data for the year 2020 based on trends observed between 2010 and 2019. The differences between the actual 2020 values reported in the statistical yearbook and the forecast values from the ARIMA model were used to assess the impact of COVID-19 on health services utilization.

Results

In 2020, the number of admissions and outpatient visits in China declined by 17.74 and 14.37%, respectively, compared to the ARIMA model’s forecast values. Notably, public hospitals experienced the largest decrease in outpatient visits and admissions, of 18.55 and 19.64%, respectively. Among all departments, the pediatrics department had the greatest decrease in outpatient visits (35.15%). Regarding geographical distribution, Beijing and Heilongjiang were the regions most affected by the decline in outpatient visits (29.96%) and admissions (43.20%) respectively.

Conclusion

The study’s findings suggest that during the first year of the COVID-19 pandemic, one in seven outpatient services and one in six admissions were affected in China. Therefore, there is an urgent need to establish a green channel for seeking medical treatment without spatial and institutional barriers during epidemic prevention and control periods.
New insights into acupuncture techniques for poststroke spasticity
Authors: Wang Jun-Xiang , Fidimanantsoa Olivia Lai , Ma Liang-Xiao
Published: April 2023

With the trend of aging population getting more obvious, stroke has already been a major public health problem worldwide. As a main disabling motor impairment after stroke, spasticity has unexpected negative impacts on the quality of life and social participation in patients. Moreover, it brings heavy economic burden to the family and society. Previous researches indicated that abnormality of neural modulation and muscle property corelates with the pathogenesis of poststroke spasticity (PSS). So far, there still lacks golden standardized treatment regimen for PSS; furthermore, certain potential adverse-events of the mainstream therapy, for example, drug-induced generalized muscle weakness or high risk related surgery somehow decrease patient preference and compliance, which brings challenges to disease treatment and follow-up care. As an essential non-pharmacological therapy, acupuncture has long been used for PSS in China and shows favorable effects on improvements of spastic hypertonia and motor function. Notably, previous studies focused mainly on the research of antispastic acupoints. In comparison, few studies lay special stress on the other significant factor impacting on acupuncture efficacy, that is acupuncture technique. Based on current evidences from the clinic and laboratory, we will discuss certain new insights into acupuncture technique, in particular the antispastic needling technique, for PSS management in light of its potential effects on central modulations as well as peripheral adjustments, and attempt to provide some suggestions for future studies with respect to the intervention timing and course, application of acupuncture techniques, acupoint selection, predictive and aggravating factors of PSS, aiming at optimization of antispastic acupuncture regimen and improvement of quality of life in stroke patients. More innovations including rigorous study design, valid objective assessments for spasticity, and related experimental studies are worthy to be expected in the years ahead.
Cracking the genetic code with neural networks
Authors: Joiret Marc , Leclercq Marine , Lambrechts Gaspard , Rapino Francesca , Close Pierre , Louppe Gilles , Geris Liesbet
Published: April 2023

The genetic code is textbook scientific knowledge that was soundly established without resorting to Artificial Intelligence (AI). The goal of our study was to check whether a neural network could re-discover, on its own, the mapping links between codons and amino acids and build the complete deciphering dictionary upon presentation of transcripts proteins data training pairs. We compared different Deep Learning neural network architectures and estimated quantitatively the size of the required human transcriptomic training set to achieve the best possible accuracy in the codon-to-amino-acid mapping. We also investigated the effect of a codon embedding layer assessing the semantic similarity between codons on the rate of increase of the training accuracy. We further investigated the benefit of quantifying and using the unbalanced representations of amino acids within real human proteins for a faster deciphering of rare amino acids codons. Deep neural networks require huge amount of data to train them. Deciphering the genetic code by a neural network is no exception. A test accuracy of 100% and the unequivocal deciphering of rare codons such as the tryptophan codon or the stop codons require a training dataset of the order of 4–22 millions cumulated pairs of codons with their associated amino acids presented to the neural network over around 7–40 training epochs, depending on the architecture and settings. We confirm that the wide generic capacities and modularity of deep neural networks allow them to be customized easily to learn the deciphering task of the genetic code efficiently.
The relationship between irritability, depression and anxiety among Chinese college students during the COVID-19 pandemic: A network analysis
Authors: Li Ling , Ren Lei , Zhan Xiaoqing , Wang Lingzhi , Liu Chang , Zhao Mengxue , Luo Xi , Feng Zhengzhi , Li Kuiliang
Published: April 2023

Introduction

Irritability, a common symptom included in the 5th Edition of Diagnostic and Statistical Manual of Mental Disorders (DSM-5), is thought to be associated with multiple emotional disorders. It is commonly seen among college students in isolation during the COVID-19 pandemic. However, its relation with anxiety and depression remains unclear. We aim to study the relation of irritability, anxiety and depression in Chinese college students during the COVID-19 pandemic by using network analysis to understand the co-occurrence of these three disorders.

Methods

During the COVID-19 pandemic, we recruited 1516 college students from five general universities in China to complete the Irritability, Depression and Anxiety Scale (IDA-S) to analyze the symptom network of irritability, depression and anxiety. Specifically, we assessed the indices of strength centrality and bridge strength for each node in the network.

Results

Some strongest linkages were found among anxiety symptoms “nervous” and “panic” (weight = 0.36), depression symptoms “sad mood” and “amused” (weight = 0.32), inward irritability items “self-hurt” and “self-harm” (weight = 0.32) and outward items “rough” and “aggressive” (weight = 0.28). The anxiety symptom “panic” had the highest strength value, followed by the inward irritability symptom “annoyed”. The nodes “ease” and “sleep” had the lowest strength value. In addition, the anxiety symptom “relax” had the highest bridge strength value, followed by inward irritability symptom “annoyed”.

Conclusion

This study explored the characteristics of a network of irritability, depression and anxiety symptoms among Chinese college students during the COVID-19 pandemic. We found that anxiety and irritability symptoms played an important role in the network. The findings provide evidence for prevention and intervention for college students' mental health problems during the COVID-19 pandemic.
The need for sharps boxes to be offered in the hospital setting for people who use substances: Removing sharps boxes puts all of us at risk
Authors: Forchuk Cheryl , Silverman Michael , Rudnick Abraham , Serrato Jonathan , Schmitt Brenna , Scott Leanne
Published: April 2023

Introduction

Substance use can occur in the hospital setting among people with substance use disorder, including intravenous use. However, the provision of sharps boxes is not typically offered in Canadian hospitals. This study set out to explore the current issues due to the lack of harm reduction in the hospital setting.

Method

Thirty-one health care professionals participated in virtual one-to-one interviews and focus groups regarding harm reduction in hospital. The issue of sharps box removal was highlighted as a concern. A secondary ethnographic thematic analysis explored this theme in more detail. A scoping review of the literature observed additional considerations.

Findings

Sharps box removal was commonplace for people who were known to be, or suspected of, using substances. Sharps boxes only to be used for medical purposes and fears of box tampering were cited as reasons for removal. Health care professionals noted that patients would have to use sharps boxes situated elsewhere. The scoping review revealed that needlestick injuries for hospital staff decreased with greater access to sharps boxes in hospital. Injuries can be addressed through safer disposal practices. Modern designs of sharps boxes and educational initiatives have been found to be successful in sharps disposal compliance and reductions in related injuries.

Discussion

Ensuring equitable access to sharps boxes would help to reduce unsafe needle discarding which can lead to needlestick injuries for hospital staff and potentially other patients. Education would be a key step in furthering understandings of the importance of sharps boxes and harm reduction as a whole.
Digital twin—The dream and the reality
Authors: Kortelainen Juha , Minav Tatiana , Tammi Kari
Published: April 2023

Digital twins (DTs) are under active research and development in the research community, industry, and in the digital engineering solution business. The roots of the concept of DT are almost 2 decades old, but the fast progress in enabling technologies, especially in data analytics, artificial intelligence, and the Internet of Things, has accelerated the evolution of DT during the last 5 years. The growing interest, increasing development activities, and increasing business opportunities of the concept are also feeding the hype in the media. Consequently, this has led to the scattering and even misuse of the concept and its definition. In this article, we discuss different applications of DTs and what kinds of solutions there are for DTs. We analyze some most cited definitions of DT in the scientific literature and discuss the interpretation of the definitions through a hypothetical case example. Furthermore, we discuss different life cycle aspects of DTs and potential risks that may arise. To further concretize the concept of DT, we introduce ten reported case examples of implemented DTs in the scientific literature and analyze their features. Finally, we discuss the future development directions of DTs and the aspects that will affect the development trends.
Flexible sensor concept and an integrated collision sensing for efficient human-robot collaboration using 3D local global sensors
Authors: Rashid Aquib , Alnaser Ibrahim , Bdiwi Mohamad , Ihlenfeldt Steffen
Published: April 2023

Human-robot collaboration with traditional industrial robots is a cardinal step towards agile manufacturing and re-manufacturing processes. These processes require constant human presence, which results in lower operational efficiency based on current industrial collision avoidance systems. The work proposes a novel local and global sensing framework, which discusses a flexible sensor concept comprising a single 2D or 3D LiDAR while formulating occlusion due to the robot body. Moreover, this work extends the previous local global sensing methodology to incorporate local (co-moving) 3D sensors on the robot body. The local 3D camera faces toward the robot occlusion area, resulted from the robot body in front of a single global 3D LiDAR. Apart from the sensor concept, this work also proposes an efficient method to estimate sensitivity and reactivity of sensing and control sub-systems The proposed methodologies are tested with a heavy-duty industrial robot along with a 3D LiDAR and camera. The integrated local global sensing methods allow high robot speeds resulting in process efficiency while ensuring human safety and sensor flexibility.
Real-time myoelectric control of wrist/hand motion in Duchenne muscular dystrophy: A case study
Authors: Nizamis Kostas , Ayvaz Anıl , Rijken Noortje H. M. , Koopman Bart F. J. M. , Sartori Massimo
Published: April 2023

Introduction: Duchenne muscular dystrophy (DMD) is a genetic disorder that induces progressive muscular degeneration. Currently, the increase in DMD individuals' life expectancy is not being matched by an increase in quality of life. The functioning of the hand and wrist is central for performing daily activities and for providing a higher degree of independence. Active exoskeletons can assist this functioning but require the accurate decoding of the users' motor intention. These methods have, however, never been systematically analyzed in the context of DMD.

Methods: This case study evaluated direct control (DC) and pattern recognition (PR), combined with an admittance model. This enabled customization of myoelectric controllers to one DMD individual and to a control population of ten healthy participants during a target-reaching task in 1- and 2- degrees of freedom (DOF). We quantified real-time myocontrol performance using target reaching times and compared the differences between the healthy individuals and the DMD individual.

Results and Discussion: Our findings suggest that despite the muscle tissue degeneration, the myocontrol performance of the DMD individual was comparable to that of the healthy individuals in both DOFs and with both control approaches. It was also evident that PR control performed better for the 2-DOF tasks for both DMD and healthy participants, while DC performed better for the 1-DOF tasks. The insights gained from this study can lead to further developments for the intuitive multi-DOF myoelectric control of active hand exoskeletons for individuals with DMD.
Bathymetric data integration approach to study bedforms in the estuary of the Saint‐Lawrence River
Authors: Noman Juzer , Cassol Willian Ney , Daniel Sylvie , Pham Van Bang Damien
Published: April 2023

The identification of bedforms has an important role in the study of seafloor morphology. The presence of these dynamic structures on the seafloor represents a hazard for navigation. They also influence the hydrodynamic simulation models used in the context, for example, of coastal flooding. Generally, MultiBeam EchoSounders (MBES) are used to survey these bedforms. Unfortunately, the coverage of the MBES is limited to small areas per survey. Therefore, the analysis of large areas of interest (like navigation channels) requires the integration of different datasets acquired over overlapping areas at different times. The presence of spatial and temporal inconsistencies between these datasets may significantly affect the study of bedforms, which are subject to many natural processes (e.g., Tides; flow). This paper proposes a novel approach to integrate multisource bathymetric datasets to study bedforms. The proposed approach is based on consolidating multisource datasets and applying the Empirical Bayesian Kriging interpolation for the creation of a multisource Digital Bathymetric Model (DBM). It has been designed to be adapted for estuarine areas with a high dynamism of the seafloor, characteristic of the fluvio-marine regime of the Estuary of the Saint-Lawrence River. This area is distinguished by a high tidal cycle and the presence of fields of dunes. The study involves MBES data that was acquired daily over a field of dunes in this area over the span of 4 days for the purpose of monitoring the morphology and migration of dunes. The proposed approach performs well with a resulting surface with a reduced error relative to the original data compared to existing approaches and the conservation of the dune shape through the integration of the data sets despite the highly dynamic fluvio-marine environments.
Distinct cognitive changes in male patients with obstructive sleep apnoea without co-morbidities
Authors: Gnoni Valentina , Mesquita Michel , O'Regan David , Delogu Alessio , Chakalov Ivan , Antal Andrea , Young Allan H. , Bucks Romola S. , Jackson Melinda L. , Rosenzweig Ivana
Published: April 2023

Introduction

Obstructive sleep apnoea (OSA) is a multisystem, debilitating, chronic disorder of breathing during sleep, resulting in a relatively consistent pattern of cognitive deficits. More recently, it has been argued that those cognitive deficits, especially in middle-aged patients, may be driven by cardiovascular and metabolic comorbidities, rather than by distinct OSA-processes, such as are for example ensuing nocturnal intermittent hypoxaemia, oxidative stress, neuroinflammation, and sleep fragmentation.

Methods

Thus, we undertook to define cognitive performance in a group of 27 middle-aged male patients with untreated OSA, who had no concomitant comorbidities, compared with seven matched controls (AHI mean ± S.D.: 1.9 ± 1.4 events/h; mean age 34.0 ± 9.3 years; mean BMI 23.8 ± 2.3 kg/m2). Of the 27 patients, 16 had mild OSA (AHI mean ± S.D.:11.7 ± 4.0 events/h; mean age 42.6 ± 8.2 years; mean BMI 26.7 ± 4.1 kg/m2), and 11 severe OSA (AHI 41.8 ± 20.7 events/h; age: 46.9 ± 10.9 years, BMI: 28.0 ± 3.2 kg/m2).

Results

In our patient cohort, we demonstrate poorer executive-functioning, visuospatial memory, and deficits in vigilance sustained attention, psychomotor and impulse control. Remarkably, we also report, for the first time, effects on social cognition in this group of male, middle-aged OSA patients.

Conclusion

Our findings suggest that distinct, OSA-driven processes may be sufficient for cognitive changes to occur as early as in middle age, in otherwise healthy individuals.
Public participation in urban design with augmented reality technology based on indicator evaluation
Authors: Wang Yuchen , Lin Yin-Shan
Published: April 2023

Decision-making processes in traditional urban design approaches are mainly top-down. Such processes have defects including not only taking a long time to examine design results but also leading to irreversible impacts after design implementation. Policymakers and researchers stress the importance of collaborating with different stakeholders in the process of urban design policy and guideline making in order to minimize these negative impacts. However, introducing public participation into urban design from the bottom up is challenging, especially when the process involves abstract urban design concepts such as indicators. This paper explores a new workflow aimed at enhancing public participation to cooperate in urban design work with the help of a newly designed platform tool powered by mobile augmented-reality technologies. The platform is intuitive to use and displays scenes of potential urban design results by superimposing the virtual models onto real-world environments on mobile devices. The public stakeholders are provided with this platform on-site to evaluate the initial values of urban design indicators by interacting with the prototype design along with an immersive experience. They can also grow familiar with the concepts of the given indicators during this process, which helps them better understand the implications of guidelines in future published urban design drafts and estimate the potential results. Their feedback is collected, which can help urban designers further optimize the indicators in urban design guideline making in order to improve their rationality. This process of urban design involving public participation is repeatable, which makes it possible to continuously adjust the design results. A user study was conducted to examine the platform’s usability and its ability to enhance public familiarity with the concepts of given indicators and their willingness to participate in urban design evaluation. The study also attests to the possibility of a workflow that integrates public feedback with the urban design process.
Gender equality approaches in water, sanitation, and hygiene programs: Towards gender-transformative practice
Authors: MacArthur Jess , Carrard Naomi , Mott Jose , Raetz Stuart , Siscawati Mia , Willetts Juliet
Published: April 2023

The recent (re-)emergence of gender-transformative approaches in the development sector has focused on transforming the gender norms, dynamics, and structures which perpetuate inequalities. Yet, the application of gender-transformative approaches within water, sanitation, and hygiene (WASH) programing remains nascent as compared with other sectors. Adopting a feminist sensemaking approach drawing on literature and practice, this inquiry sought to document and critically reflect on the conceptualization and innovation of gender-transformative thinking in the Australian Government's Water for Women Fund. Through three sensemaking workshops and associated analysis, participants developed a conceptual framework and set of illustrative case examples to support WASH practitioners to integrate strengthened gender-transformative practice. The multi-layered framework contains varied entry points to support multi-disciplinary WASH teams integrating gender equality, as skills and resources permit. Initiatives can be categorized as insensitive, sensitive, responsive or transformative, and prompted by five common motivators (welfare, efficiency, equity, empowerment, and transformative requality). The framework has at its foundation two diverging tendencies: toward instrumental gender potential and toward transformative gender potential. The article draws on historical and recent WASH literature to illustrate the conceptual framework in relation to: (i) community mobilization, (ii) governance, service provision, and oversight, and (iii) enterprise development. The illustrative examples provide practical guidance for WASH practitioners integrating gendered thinking into programs, projects, and policies. We offer a working definition for gender-transformative WASH and reflect on how the acknowledgment, consideration, and transformation of gender inequalities can lead to simultaneously strengthened WASH outcomes and improved gender equality.
Game Changers: A participatory action research project for/with students with disabilities in school sport settings
Authors: Robinson Daniel B. , Harenberg Sebastian , Walters William , Barrett Joe , Cudmore Anna , Fahie Kelsey , Zakaria Tricia
Published: April 2023

Introduction

Although school communities may be required to provide physical education opportunities for all students—including for those with disabilities—the same is not generally true with respect to school sport (i.e., participation in interscholastic or intramural sport programs). Hence, opportunities for inclusive school sport participation are consequently limited. Recognizing the need for continued attention and action in this area, we recently developed and piloted Game Changers—a participatory action research project. Together, 27 students with various cognitive and/or intellectual disabilities (i.e., student-participants), their schools’ six physical education teachers and learning support teachers (i.e., champion-participants), four university researchers (i.e., researcher-participants), and two community partners [i.e., Physical and Health Education (PHE) Canada, Special Olympics Nova Scotia] engaged in the Game Changers project with three idealized goals: (a) to bring to the fore para/adapted/inclusive sport opportunities for all students; (b) to provide an empowering opportunity for students with disabilities to participate, make choices, and act as leaders in the development of sport programming; and (c) to engage youth with disabilities in sport as participants, leaders, mentors, and role models.

Methods

Utilizing a mixed-methods design, data were collected from a variety of sources before the implementation of the Game Changers program, during its implementation, and once it was complete. These four data sources included the following: pre- and post-program survey for student-participants, pre- and post-program focus group interviews for student-participants, pre- and post-program focus group interviews for champion-participants, and school/sport observations.

Results

The first cycle of this participatory action research project has yielded positive and informative findings. Strictly positive findings, among others, relate to the following: improving upon students' perceived competence and autonomy, inviting student voice, identifying and responding to sport participation barriers, and creating genuine sport opportunities within school settings. More undesirable yet informative findings, among others, relate to the following: unachieved intrinsic motivation and belonging, (un)sustainability of sport programs without “interventions” like Game Changers, recreation/leisure as “substitutes” for sport, and a continued want for authentic leadership and mentorship opportunities.

Discussion

With these findings, we offer insights for future iterations of Game Changers (and programs like it) in similar school communities.
Trenchant microbiological-based approach for the control of Striga: Current practices and future prospects
Authors: Olowe Olumayowa Mary , Akanmu Akinlolu Olalekan , Ayangbenro Ayansina Segun , Fadiji Ayomide Emmanuel , Bitire Tope Daniel , Odhiambo Jude J. O. , Kutu Funso Rahael , Babalola Olubukola Oluranti
Published: April 2023

Striga species are obligate parasitic weeds most of which are members of the Orobanchaceae family. They are commonly associated with staple crops and constitute threats to food security, especially in Sub-Saharan Africa. They pose deleterious impacts on staple cereal crops like maize and pearl millet, resulting in 7–10 billion dollars yield losses or, in extreme infestations, entire crop losses. Farmers' limited knowledge about the weed (genetics, ecology, nature of the damage caused, complex life cycle, interactions with its host and associated microbes) and their attitude toward its control have negatively affected its management and sustainability. With the present Striga management such as mechanical, chemicals, cultural and biological measures, it is extremely difficult to achieve its active management due to nature of the association between host plants and parasites, which requires highly selective herbicides. The use of soil microbes has not been well explored in the management of Striga infection in African countries. However, many soil microorganisms have been considered viable biological control techniques for fighting parasitic weeds, due to their vast action and roles they play in the early stage of host-Striga interaction. Their application for pest control is well perceived to be cost-effective and eco-friendly. In this review, we gave a comprehensive overview of major knowledge gaps and challenges of smallholders in Striga management and highlighted major potentials of microbial-based approach with respect to the mechanisms of host-Striga-microbe interactions, and the metagenomics roles on Striga management that include understanding the microbe and microbial systems of Striga-infested soil.
Halal or not? Exploring Muslim perceptions of cultured meat in Singapore
Authors: Ho Shirley S. , Ou Mengxue , Vijayan Andrew Vimal
Published: April 2023

Singapore was the first country to approve cultured meat for public consumption. However, it remains unclear whether Muslims, who adhere to religious dietary restrictions and constitute a significant proportion of Singapore's population, are willing to consume cultured meat. Informed by the cognitive miser model, this study explores how Muslims make sense of cultured meat through their religious beliefs, trust in different stakeholders, as well as their risk or benefit perceptions of cultured meat. The findings from online focus group discussions showed that Muslim participants would only consider consuming cultured meat if it is certified halal (i.e., compliant with Islamic laws) and they also voiced religious concerns about cultured meat. Muslims have strong trust in food regulatory authorities in providing information about the safety and halal status of cultured meat. In addition to religious concerns, Muslims had similar risk and benefit perceptions of cultured meat compared to those of the non-Muslims. Theoretical and practical implications were discussed.
An Approach for Opening Doors with a Mobile Robot Using Machine Learning Methods
Authors: Mochurad Lesia , Hladun Yaroslav , Zasoba Yevgen , Gregus Michal
Published: April 2023

One of the tasks of robotics is to develop a robot’s ability to perform specific actions for as long as possible without human assistance. One such step is to open different types of doors. This task is essential for any operation that involves moving a robot from one room to another. This paper proposes a versatile and computationally efficient algorithm for an autonomous mobile robot opening different types of doors, using machine learning methods. The latter include the YOLOv5 object detection model, the RANSAC iterative method for estimating the mathematical model parameters, and the DBSCAN clustering algorithm. Alternative clustering methods are also compared. The proposed algorithm was explored and tested in simulation and on a real robot manufactured by SOMATIC version Dalek. The percentage of successful doors opened out of the total number of attempts was used as an accuracy metric. The proposed algorithm reached an accuracy of 95% in 100 attempts. The result of testing the door-handle detection algorithm on simulated data was an error of 1.98 mm in 10,000 samples. That is, the average distance from the door handle found by the detector to the real one was 1.98 mm. The proposed algorithm has shown high accuracy and the ability to be applied in real time for opening different types of doors.
The Effectiveness of Calcium Phosphates in the Treatment of Dentinal Hypersensitivity: A Systematic Review
Authors: Maillard Mélanie , Bandiaky Octave Nadile , Maunoury Suzanne , Alliot Charles , Alliot-Licht Brigitte , Serisier Samuel , Renard Emmanuelle
Published: April 2023

Dentin hypersensitivity (DH) pain is a persistent clinical problem, which is a common condition known to affect patients’ quality of life (QoL), but no treatment has ever been agreed upon. Calcium phosphates, available in different forms, have properties that allow sealing the dentinal tubules, which may relieve dentin hypersensitivity. The aim of this systematic review is to evaluate the ability of different formulations of calcium phosphate to reduce dentin hypersensitivity pain level in clinical studies. The inclusion criterion was as follows: clinical randomized controlled studies using calcium phosphates in treating dentin hypersensitivity. In December 2022, three electronic databases (Pubmed, Cochrane and Embase) were searched. The search strategy was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The bias assessment risks results were carried out using the Cochrane Collaboration tool. A total of 20 articles were included and analyzed in this systematic review. The results show that calcium phosphates have properties that reduce DH-associated pain. Data compilation showed a statistically significant difference in DH pain level between T0 and 4 weeks. This VAS level reduction is estimated at about −2.5 compared to the initial level. The biomimetic and non-toxic characteristics of these materials make them a major asset in treating dentin hypersensitivity.
Molecular Similarities and Differences between Canine Prostate Cancer and Human Prostate Cancer Variants
Authors: Vasilatis Demitria M. , Lucchesi Christopher A. , Ghosh Paramita M.
Published: April 2023

Dogs are one of few species that naturally develop prostate cancer (PCa), which clinically resembles aggressive, advanced PCa in humans. Moreover, PCa-tumor samples from dogs are often androgen receptor (AR)-negative and may enrich our understanding of AR-indifferent PCa in humans, a highly lethal subset of PCa for which few treatment modalities are available This narrative review discusses the molecular similarities between dog PCa and specific human-PCa variants, underscoring the possibilities of using the dog as a novel pre-clinical animal model for human PCa, resulting in new therapies and diagnostics that may benefit both species.
Strategies to Re-Sensitize Castration-Resistant Prostate Cancer to Antiandrogen Therapy
Authors: Congregado Ruiz Belén , Rivero Belenchón Inés , Lendínez Cano Guillermo , Medina López Rafael Antonio
Published: April 2023

Since prostate cancer (PCa) was described as androgen-dependent, the androgen receptor (AR) has become the mainstay of its systemic treatment: androgen deprivation therapy (ADT). Although, through recent years, more potent drugs have been incorporated, this chronic AR signaling inhibition inevitably led the tumor to an incurable phase of castration resistance. However, in the castration-resistant status, PCa cells remain highly dependent on the AR signaling axis, and proof of it is that many men with castration-resistant prostate cancer (CRPC) still respond to newer-generation AR signaling inhibitors (ARSis). Nevertheless, this response is limited in time, and soon, the tumor develops adaptive mechanisms that make it again nonresponsive to these treatments. For this reason, researchers are focused on searching for new alternatives to control these nonresponsive tumors, such as: (1) drugs with a different mechanism of action, (2) combination therapies to boost synergies, and (3) agents or strategies to resensitize tumors to previously addressed targets. Taking advantage of the wide variety of mechanisms that promote persistent or reactivated AR signaling in CRPC, many drugs explore this last interesting behavior. In this article, we will review those strategies and drugs that are able to resensitize cancer cells to previously used treatments through the use of “hinge” treatments with the objective of obtaining an oncological benefit. Some examples are: bipolar androgen therapy (BAT) and drugs such as indomethacin, niclosamide, lapatinib, panobinostat, clomipramine, metformin, and antisense oligonucleotides. All of them have shown, in addition to an inhibitory effect on PCa, the rewarding ability to overcome acquired resistance to antiandrogenic agents in CRPC, resensitizing the tumor cells to previously used ARSis.
The Extracellular Matrix: Its Composition, Function, Remodeling, and Role in Tumorigenesis
Authors: Dzobo Kevin , Dandara Collet
Published: April 2023

The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular processes, the extracellular matrix has been shown to have diverse components that regulate and activate many cellular processes and ultimately influence cell phenotype. Importantly, the ECM’s composition, architecture, and stiffness/elasticity influence cellular phenotypes. Under normal conditions and during development, the synthesized ECM constantly undergoes degradation and remodeling processes via the action of matrix proteases that maintain tissue homeostasis. In many pathological conditions including fibrosis and cancer, ECM synthesis, remodeling, and degradation is dysregulated, causing its integrity to be altered. Both physical and chemical cues from the ECM are sensed via receptors including integrins and play key roles in driving cellular proliferation and differentiation and in the progression of various diseases such as cancers. Advances in ‘omics’ technologies have seen an increase in studies focusing on bidirectional cell–matrix interactions, and here, we highlight the emerging knowledge on the role played by the ECM during normal development and in pathological conditions. This review summarizes current ECM-targeted therapies that can modify ECM tumors to overcome drug resistance and better cancer treatment.
Continuum Robots: From Conventional to Customized Performance Indicators
Authors: Russo Matteo , Gautreau Elie , Bonnet Xavier , Laribi Med Amine
Published: April 2023

Continuum robots have often been compared with rigid-link designs through conventional performance metrics (e.g., precision and Jacobian-based indicators). However, these metrics were developed to suit rigid-link robots and are tuned to capture specific facets of performance, in which continuum robots do not excel. Furthermore, conventional metrics either fail to capture the key advantages of continuum designs, such as their capability to operate in complex environments thanks to their slender shape and flexibility, or see them as detrimental (e.g., compliance). Previous work has rarely addressed this issue, and never in a systematic way. Therefore, this paper discusses the facets of a continuum robot performance that cannot be characterized by existing indicator and aims at defining a tailored framework of geometrical specifications and kinetostatic indicators. The proposed framework combines the geometric requirements dictated by the target environment and a methodology to obtain bioinspired reference metrics from a biological equivalent of the continuum robot (e.g., a snake, a tentacle, or a trunk). A numerical example is then reported for a swimming snake robot use case.
Biomimetic Design and Topology Optimization of Discontinuous Carbon Fiber-Reinforced Composite Lattice Structures
Authors: Hu Zhong
Published: April 2023

The ever-increasing requirements for structural performance drive the research and development of lighter, stronger, tougher, and multifunctional composite materials, especially, the lattice structures, heterogeneities, or hybrid compositions have attracted great interest from the materials research community. If it is pushed to the extreme, these concepts can consist of highly controlled lattice structures subject to biomimetic material design and topology optimization (TO). However, the strong coupling among the composition and the topology of the porous microstructure hinders the conventional trial-and-error approaches. In this work, discontinuous carbon fiber-reinforced polymer matrix composite materials were adopted for structural design. A three-dimensional (3D) periodic lattice block inspired by cuttlefish bone combined with computer modeling-based topology optimization was proposed. Through computer modeling, complex 3D periodic lattice blocks with various porosities were topologically optimized and realized, and the mechanical properties of the topology-optimized lattice structures were characterized by computer modeling. The results of this work were compared with other similar designs and experiments to validate the effectiveness of the proposed method. The proposed approach provides a design tool for more affordable and higher-performance structural materials.
Drying Behaviour of Al2O3 Inks Containing Carboxymethylcellulose (CMC) for Use in Colloidal Processing
Authors: Silva Bruno Medeiros da , Santos Ésoly Madeleine Bento dos , Souza Vinícius Zancanelli Bôsco de , Alves Manuel Fellipe Rodrigues Pais , Vieira Carlos Maurício , Santos Claudinei dos
Published: April 2023

One of the most important steps in the extrusion processing of ceramic inks is the initial drying of the ceramic parts. This study aimed to investigate the drying behaviour of an Al2O3-based ceramic ink optimised to be processed by extrusion processing methods, e.g., direct ink writing. Carboxymethylcellulose (CMC) was singly added to a suspension of deionised water and Al2O3 (50:50 wt.%) to perform as a dispersing and plasticising agent. To assess moisture loss as a function of time, the ceramic inks were extruded into two types of polymeric moulds: one with a completely closed profile producing cylindrical samples (disks) and one with an open profile producing ceramic bars. After the injection of the inks, the moulds were exposed to different controlled temperatures (20 and 40 °C) for up to 180 h; moisture loss and warpage were periodically measured, and exponential mathematical expressions (moisture loss × drying time) were obtained. The Al2O3-bars dried for 24 h in open moulds at 20 and 40 °C presented longitudinal warpages of 4.5% and 9%, respectively, while the Al2O3 disks dried in closed moulds presented warpages of 3.5% and 7% in these same temperatures (20 and 40 °C, respectively). The samples were sintered at 1610 °C for 4 h and characterised by scanning electron microscopy (SEM), relative density (Archimedes principle), and X-ray diffraction (XRD), presenting a relative density of 92.3 ± 0.5%, α-Al2O3 as crystalline phase and grain with equiaxed morphology varying between 1 and 5 μm.
Short-Term Outcomes of an ESDM Intervention in Italian Children with Autism Spectrum Disorder following the COVID-19 Lockdown
Authors: Devescovi Raffaella , Bresciani Giulia , Colonna Vissia , Carrozzi Marco , Dissegna Andrea , Celea Maria Antonella , Cescon Devid , Frisari Sara , Guerrieri Marcella , Placer Francesca , Stocchi Monica , Terpini Chiara , Colombi Costanza
Published: April 2023

The COVID-19 pandemic caused a temporary lockdown period in Italy, during which the delivery of in-person treatment for children with autism spectrum disorder (ASD) in public health services was discontinued. This occurrence represented a crucial challenge for both families and professionals. We assessed the short-term outcomes of a sample of 18 children who received an early intervention with the Early Start Denver Model (ESDM), delivered at low intensity over one year in the pre-pandemic period, after six months of interruption of in-presence treatment due to lockdown restrictions. Children who received the ESDM treatment maintained their gains in sociocommunicative skills and did not exhibit any developmental regression. Additionally, there was evidence of a decrease in the restrictive and repetitive behavior (RRB) domain. The parents, who were already familiar with the principles of the ESDM, only received telehealth support from therapists that aimed to sustain the gains already achieved. We believe that it is always helpful to support parents in their daily lives by implementing interactional and play skills with their children to integrate and consolidate the results obtained in the individual interventions conducted by experienced therapists.
Different Directions of Effects of Polyclonal IgG Antibodies from Patients with Schizophrenia and Healthy Individuals on Cell Death In Vitro: A Pilot Study
Authors: Epimakhova Elena V. , Smirnova Liudmila P. , Kazantseva Daria V. , Kamaeva Daria A. , Ivanova Svetlana A.
Published: April 2023

Numerous studies indicate the involvemen of oxidative stress in the pathogenesis of schizophrenia. It has been shown that the serum pool of antibodies in patients with schizophrenia contains catalytically active antibodies (abzymes) that have a wide range of activities, including redox properties. In the present work, the effects of IgGs—having oxidoreductase activities—isolated from the serum of patients with schizophrenia and healthy individuals were studied in vitro. The IgGs were purified by affinity chromatography followed by an SDS-PAGE analysis of homogeneity in a 4–18% gradient gel. The catalase and superoxide dismutase (SOD) activities of the IgGs were measured spectrophotometrically using a kinetic module. Human neuroblastoma SH-SY5Y cells were cultured with IgG at a final concentration of 0.2 mg/mL for 24 h. In a parallel experiment, tert-butyl hydroperoxide was used as an oxidative stressor. The number of dead cells after incubation was determined with fluorescent dyes, propidium iodide and Hoechst, by high-throughput screening on the CellInsight CX7 platform. A cytotoxic effect of the IgG from the schizophrenia patients on SH-SY5Y cells was detected after 24 h incubation. A correlation was found between the SOD activity of the IgGs and IgG-induced cell death. Under the induced oxidative stress, the cytotoxic effect of the IgG from the patients with schizophrenia on the SH-SY5Y cell line was five times stronger. Meanwhile, the IgG from the healthy individuals exerted a cytoprotective effect on the cultured cells, accompanied by high catalase activity. Thus, the observed influence on cell viability depends on the catalytic properties of the abzymes.