bluuebunny/crossref_metadata_2025 huggingface dataset:
Heart, Mind and Body: #NoMorePage3 and the Replenishment of Emotional Energy
Authors: McCarthy Lauren , Glozer Sarah
Published: February 2021

Emotional energy is key to disruptive institutional work, but we still know little about what it is, and importantly, how it is refuelled. This empirical paper presents an in-depth case study of ‘No More Page 3’ (#NMP3), an Internet-based feminist organization which fought for the removal of sexualized images of women from a UK newspaper. Facing online misogyny, actors engage in ‘emotional energy replenishment’ to sustain this disruptive institutional work amid emotional highs and lows. We introduce ‘affective embodiment’ – the corporeal and emotional experiences of the institution – as providing emotional energy in relation to disruptive institutional work. Affective embodiment is surfaced through alignment or misalignment with others’ embodied experiences, and this mediates how actors replenish emotional energy. Alignment with others’ embodied experiences, often connected to online abuse, means emotional energy is replenished through ‘affective solidarity’ (movement towards the collective). Misalignment, surfaced through tensions within the movement, means actors seek replenishment through ‘sensory retreat’ (movement away from the collective). This study contributes to theorization on institutional work and emotional energy by recentring the importance of the body alongside emotions, as well as offering important lessons for online organizing.
Multidirectional Idea Travelling Across an Organizational Field
Authors: Nielsen Jeppe Agger , Mathiassen Lars , Newell Sue
Published: February 2021

Organizational scholars are increasingly interested in understanding how ideas travel across an organizational field. While most studies focus on how travelling ideas translate into organizational practices, we lack insights into the broader issue of how ideas translate as they move among heterogeneous actors across the field. To explore this multidirectional travelling of ideas, we build on the notion of translation ecology to capture the ongoing interactions among field members as they are involved in translation work within and outside adopting organizations. To develop our argument, we draw from a longitudinal, 20-year case study of a public sector digital transformation programme in Denmark through which ideas about mobile technology use for caregivers spread across the entire homecare field. By following the mobile technology initiative over time, we show how ideas travelled in multiple directions as adopting organizations and other influential field actors participated in and contributed to diverse practices across organizations. Based on our analyses, we identify three distinct forms of multidirectional idea travelling – reinforcing, complementing and polarizing – and describe how they together shape the morphing of ideas as they move among heterogeneous actors in a translation ecology. As a result, we advance knowledge about multidirectional idea travelling as an under-theorized and important perspective in the translation literature.
Cañari children, cows and milk production: Toward ch’ixi temporalities in the Andes
Authors: Pacini-Ketchabaw Veronica , Vintimilla Cristina D , Berry Alex
Published: February 2021

This article considers the intersection of multiple and, at times, seemingly conflicting temporalities in Andean childhoods. We draw on Silvia Rivera Cusicanqui’s scholarship on Andean sociology and our ethnographic research with Cañari families to argue that Cañari families’ and children’s relations with cows and milk production are fueled by both capitalist and Andean temporalities that cannot be thought as opposites. These temporal relations do not create confusion or limiting binaries but are, we propose, itinerant. We show how Cañari children’s and cows’ collective lives are knitted within ch’ixi temporalities.
Acid-fast bacilli smear test of a blood culture sample for the diagnosis of disseminated Mycobacterium genavense infection: A case report
Authors: Murata Yo , Mori Nobuaki , Kagawa Narito , Okuma Kentaro , Yoshida Shinji , Ohkusu Kiyofumi , Honda Miwako
Published: February 2021

Mycobacterium genavense, a nontuberculous Mycobacterium, is found in immunosuppressed patients, particularly in those with HIV. Mycobacterium genavense incubation under standard culture conditions is difficult, and its identification is challenging using routine culture methods. Herein, we report the case of a 40-year-old Japanese man with HIV presenting with disseminated M. genavense infection. An analysis using an automated blood culture system did not show positive signals during 6 weeks of incubation. However, an acid-fast bacilli smear of his blood sample was positive for the bacterium. Mycobacterium genavense was identified using sequencing analysis, targeting the heat shock protein 65 gene. The patient recovered from the infection, following antibiotic therapy for 18 months. Under suspicion of disseminated M. genavense infection and the absence of bacterial growth in blood culture samples, an acid-fast bacilli smear test of the sample may be useful for timely diagnosis.
Frequency of pregnant women who accept HIV screening using rapid detection test and factors associated with acceptance
Authors: Khatoon Aisha , Husain Samia , Husain Sonia , Hussain Saba
Published: February 2021

To assess the frequency of pregnant women who accept HIV screening using rapid detection test and factors associated with acceptance we undertook a cross-sectional study conducted from July to December 2018. Women aged 20–45 years, who were pregnant and planned to deliver at the facility, were included. Women were counseled and offered about Human Immunodeficiency virus (HIV) screening. A total of 718 women were included in the study. The screening was accepted by 32.3% of women. Six women tested positive in the study giving a seroprevalence of 0.8% in the population studied. Acceptance of counseling and screening varied significantly with age range, educational status, socioeconomic status, and employment status. Women aged 30 years and above ( p = 0.023) and women with higher education ( p < 0.001) were more likely to refuse counselling. Similarly, employed women (p = 0.041) and women of higher socioeconomic class ( p = 0.039) refused counselling. However, when logistic regression was conducted, only educational status ( p < 0.001) and occupational status ( p = 0.039) were significantly associated with acceptance of counseling and screening. The acceptance of counselling and testing for HIV in antenatal care attendees was low. Women of higher educational status and having some employment refused counselling and testing more commonly.
The Sleep Paradox: A Retrospective Exploration into Sleeplessness and Aberrant Sleep Patterns to Gain Insights into Entrepreneurial Psychology and Behaviour
Authors: Racine William P.
Published: February 2021

The need for sleep has important implications for entrepreneurship. Researchers have come to understand that sleep insufficiency affects creativity, innovation, self-control and operational efficacy. Yet quality sleep often eludes an entrepreneur because of the demands from the business environment, fear of failure and job insecurity, among other things. Hence, a sleep paradox exists where aberrant sleep patterns or sleeplessness undermine success. However, aberrant sleep patterns and sleeplessness are a necessary part of successful entrepreneurial experiences. The current research used a qualitative design to understand how successful entrepreneurs retrospectively perceive aberrant sleep patterns or sleep restriction (i.e., sleeplessness); but, more importantly, how they implement coping mechanisms to overcome this paradox to achieve positive outcomes for their business. Successful entrepreneurs of the current research were seen to self-regulate their actions to address the vagaries of entrepreneurial experience. They manage aberrant sleep patterns or sleeplessness by taking steps to develop adaptative tools (i.e., coping mechanisms such as mental, physical and behavioural shortcuts) to aid decision-making in an uncertain business environment and to facilitate the sustainability of their entrepreneurial endeavours.
Understanding the Impact of COVID-19 Pandemic Outbreak on Grocery Stocking Behaviour in India: A Pattern Mining Approach
Authors: Bandyopadhyaya Vijaya , Bandyopadhyaya Ranja
Published: February 2021

The outbreak and worldwide spread of the COVID-19 pandemic is unprecedented in recent human memory and has affected normal lifestyle of people worldwide. The lockdown restrictions imposed by countries across the globe created concerns about food availability and this affected grocery purchase and stocking behaviour of households. Researchers worldwide started analysing the nature and trend of changes in the behaviour and effect of socio-demographic factors on the change. However, limited studies have been undertaken in the Indian context. Also, how family structure influences panic buying behaviour has not been studied in detail so far. This work studies in detail whether the pandemic outbreak affected grocery purchase trends of Indian households in terms of the duration for which grocery purchase was being made, amount spent on grocery shopping per purchase and type of grocery items preferred using an online household survey of 506 families from all over India. Also, the influence of household income, family structure and grocery availability and delivery issues on grocery stocking behaviour has been studied in detail using Apriori algorithm. It was observed that panic buying is a reality, and quantity stocked and amount spent per purchase changed significantly after outbreak of the pandemic. Also, family income, size and presence of elderly and children in the household were found to affect buying patterns. Though it is difficult to predict long-term effect on behaviour change, with fear of prolonged pandemic situation and many countries resuming lockdown for a second time, this study is expected to be effective for design of supply policies of essentials in the new normal situation.
Venous Thromboembolism, Corticosteroids and COVID-19: A Systematic Review and Meta-Analysis
Authors: Sarfraz Azza , Sarfraz Zouina , Razzack Aminah Abdul , Patel Gaurav , Sarfraz Muzna
Published: February 2021

The novel coronavirus disease 2019 (COVID-19) predisposes patients to venous thromboembolism (VTE) due to risk factors, severe infection, and severe inflammatory responses. The objective is to determine the risk of developing VTE after corticosteroid administration during COVID-19 treatment. Using PRISMA reporting guidelines, a review was conducted from inception until 20 September 2020 with MESH terms including “venous thromboembolism” and “covid-19,” using MEDLINE, Scopus, CINAHL Plus, and WHO Global Database. The inclusion criteria included studies with COVID-19 patients aged 18 years and older with VTE diagnosed by duplex ultrasonography or computed tomography pulmonary angiography (CTPA). Exclusion criteria were studies with non COVID-19 patients and non-VTE patients aged less than 18 years. Quality appraisal was conducted of included studies using the Newcastle-Ottawa Scale (NOS). A random-effect model using 95% confidence intervals, and significance of findings was assessed using Review Manager V5.4.We included 12 observational studies with 2801 patients (VTE n = 434; non-VTE; n = 2367). Patients had a higher risk of presenting with VTE when being administered corticosteroids during treatment of COVID-19 (RR = 1.39, 95% CI = 1.10 to 1.77, I2 = 0%). A positive effect size was found (SMD = 1.00, 95% CI = 0.67 to 1.32, I2 = 85%) for D-dimer laboratory values (µg/mL) in the VTE group. While critically ill COVID-19 patients are more likely to require corticosteroid treatment, it may be associated with increased risk of VTE, and poor clinical prognosis. Risk assessment is warranted to further evaluate patients as case-by-case in reducing VTE and worsening clinical outcomes.
The Nexus Of Foreign Reserves, Exchange Rate And Inflation: Recent Empirical Evidence From Sri Lanka
Authors: Ariyasinghe Ayesh , Cooray N. S.
Published: February 2021

The conventional mandates of the central banks on meeting stability objectives and maintaining a growth-maximizing inflation rate have come under some criticism since the global financial crises. Maintaining adequate foreign reserves is seen as a viable solution to foreign exchange liquidity needs during crisis periods. Since the end of 2011, many Asian economies, including China and Japan, led from the forefront in central bank-led reserves build-up. However, reserves build-up remains challenging and sensitive for small open economies. Such policies help create ‘risk-neutral’ buffers for monetary and fiscal authorities to absorb transitory current account shocks and foreign exchange stress to smoothen the balance of payments. This study is motivated by the importance of identifying the inflation–foreign reserves nexus that may affect inflation in a manner counterproductive to the central bank mandate of maintaining price stability. It probes the debate of the sustainability of reserves build-up in the long and the short term. The outcome of the study poses several vital questions for fiscal and monetary policymakers concerning their respective mandates. The reserves–inflation nexus and its magnitude is determined using monthly data spanning two decades, through engaging an autoregressive distributed lag (ARDL) model and relevant bounds-testing techniques proposed by Pesaran et al. The vector autoregression (VAR), error correction and Johansen cointegration methods supplement the robustness checks. Exchange rate is introduced to enrich the discussion on the reserves–inflation nexus and shows a cointegration relationship in the long run. The study provides an insight into the influence of exchange rate on reserves and inflation. The variance decomposition shows the presence of a lukewarm response from foreign reserves and exchange rate on inflation. Policymakers concerned with inflationary expectations in the medium-to-long term need to consider these signals, as reserves build-up is one of the important policy-driven objectives for a number of economies.

JEL: C50, C32, E31, E52, E58, F30, F31, F39
Political discontent and labour in a post-growth region: A view from East Germany
Authors: Schmalz Stefan , Singe Ingo , Hasenohr Anne
Published: February 2021

The article traces the political economy and labour relations in East Thuringia, a ‘post-growth region’ in East Germany with a structurally weak periphery and a declining populace. We argue that the regional decline results from a process of peripheralization which has led to economic stagnation and a shrinking population, and also has fostered political discontent. By drawing on a regional survey, an intensive case study at a manufacturing site and qualitative interviews with policy makers, managers, works council members and employees, we analyse how peripheralization has impacted labour relations and politics in a shrinking region. We discuss our findings by referring to current political sociology debates on the rise of right-wing populism and the scientific discussion on post-growth, as well as recent approaches of critical geography and development sociology. We show how feelings of injustice such as anger about low wages and the democratic void at work interlink with pessimistic assessments concerning the region’s future and feelings of deprivation. We conclude that the economic model based on labour-intensive exports in the internal periphery of East German capitalism is eroding and is contributing to a crisis of hegemony and political instability.
Influence of glutamate and GABA transport on brain excitatory/inhibitory balance
Authors: Sears Sheila MS , Hewett Sandra J
Published: February 2021

An optimally functional brain requires both excitatory and inhibitory inputs that are regulated and balanced. A perturbation in the excitatory/inhibitory balance—as is the case in some neurological disorders/diseases (e.g. traumatic brain injury Alzheimer’s disease, stroke, epilepsy and substance abuse) and disorders of development (e.g. schizophrenia, Rhett syndrome and autism spectrum disorder)—leads to dysfunctional signaling, which can result in impaired cognitive and motor function, if not frank neuronal injury. At the cellular level, transmission of glutamate and GABA, the principle excitatory and inhibitory neurotransmitters in the central nervous system control excitatory/inhibitory balance. Herein, we review the synthesis, release, and signaling of GABA and glutamate followed by a focused discussion on the importance of their transport systems to the maintenance of excitatory/inhibitory balance.
Challenging Whiteness at Claremont High School
Authors: Watson Terri Nicol , Miles Nash Angel
Published: February 2021

Ebony Wright was slated to graduate from Claremont High School in the spring. She was on the honor roll, captain of the girls’ varsity softball and swim teams, and recently awarded an academic scholarship to attend a highly ranked university in the fall. Ebony was a “model” student. How she found herself sitting in the principal’s office several weeks before graduation was a shock to everyone. This case study challenges the function of whiteness in school policies. Aspiring school and teacher leaders are provided with the opportunity to consider the impact of a seemingly race-neutral school dress code policy.
Transseptal Puncture Learning Curve for Transcatheter Edge-to-Edge Mitral Valve Repair
Authors: Quinn Rachael W. , Vesely Mark R. , Dawood Murtaza , Benitez Michael , Holmes Sari D. , Gammie James S.
Published: February 2021

Objective

This study examined the learning curve for transseptal puncture (TSP) during transcatheter edge-to-edge mitral valve repair (TEER) performed by a dedicated mitral valve structural heart team. Effective TSP is mandatory for TEER but can be time-consuming and associated with complications including pericardial effusion and cardiac tamponade.

Methods

TSP was performed on 107 consecutive patients (76 ± 1 years, 52% male) undergoing TEER between 2014 and 2019. TSP was performed by each structural heart team member (1 cardiologist, 2 cardiac surgeons) on a rotating case-by-case basis. No team member had prior independent TSP experience. Data collected included total procedure time, TSP time (time elapsed between procedure start and septal crossing), and number of TSP attempts before successful puncture. Cumulative sum (CUSUM) of deviations from the mean across sequential cases were used to examine learning curves.

Results

Median total procedure time was 107 min, and the median TSP time was 14 min. Greater case number was significantly associated with both lower TSP time ( r s = −0.22, P = 0.022) and lower total procedure time ( r s = −0.29, P = 0.003). The majority of patients required only 1 TSP attempt (79%). There was a significant quadratic relationship between case number and the CUSUM for TSP time, with the learning curve peaking at 49 cases.

Conclusions

TSP for TEER has a substantial learning curve, requiring >50 cases to achieve acceptable efficiency. Even once proficiency is demonstrated, TSP remains a time-consuming component of TEER. Improvements in transseptal access technology may significantly decrease the time needed to master TSP and may improve the safety and precision of the procedure.
Reducing the incidence of pin site infection in hand surgery with the use of a protocol from Ilizarov
Authors: Solari Mattia , Kapur Benjamin , Benjamin-Laing Harry , Klass Benjamin R. , Cheung Graham , Brown Daniel J.
Published: February 2021

Reported pin site infection rates in Kirschner wire fixation in the hand and wrist vary from 2% to 35%. In our unit we follow a strict pin site management protocol adapted from the Russian Ilizarov Scientific Centre. This study aims to identify if our current protocol reduces the incidence of pin site infection in hand and wrist surgery, and improves wire survival rates, to a level where exposed wires can be used safely. A retrospective review of 200 patients, treated with 369 percutaneous wires, in our hand surgery department over a 6-year period was carried out. Nine patients (4.5%) were diagnosed with a pin site infection with a wire survival rate of 99.5%.In our unit using our current protocol, results support the safe use of exposed wires with appropriate pin site care initiated in theatre. Adherence to this protocol allows wires to remain in-situ throughout treatment with minimal complications.

Level of evidence: IV
Primary care for asylum seekers and refugees
Authors: Aspray Nathaniel , Matsiko Judith
Published: February 2021

Clinicians often find consultations with asylum seekers and refugees challenging, with significant and multifactorial barriers to good care. Patients often have to overcome such barriers even before arriving in the consulting room, ranging from difficulty accessing healthcare to differing health beliefs. As a result, the role of the GP in providing holistic care is essential when looking after this vulnerable group of patients. This article focuses on asylum seekers and refugees but other migrants may face similar challenges.
Primary Care Shortage in Medically Underserved and Health Provider Shortage Areas: Lessons from Delaware, USA
Authors: Malayala Srikrishna Varun , Vasireddy Deepa , Atluri Paavani , Alur Ram Sanjeev
Published: February 2021

Objective:

To examine the reasons contributing to the physician shortage in the country’s medically underserved areas using the state of Delaware as a focus state.

Method:

A literature review regarding the shortage of physicians with data compilation from Delaware Department of Public Health (DPH) and Delaware Health and Social services (DHSS) was performed. A review of the “Conrad 30 J1 VISA waiver program,” the most important and primary supplier of physicians to underserved areas of the state was performed. A survey interviewing the physicians recruited through this program to identify any challenges faced by them was designed and conducted.

Results:

The number of primary care physicians providing direct patient care in Delaware in 2018 had declined about 6% from 2013. The average wait time to see a PCP was 8.2 days in 1998 as compared to 23.5 days in 2018. Forty-six percent of physicians serving in HPSAs in Delaware are IMGs recruited through the J1 VISA waiver program. Eighty percent of these IMGs are actively considering leaving the United States due to anxieties around physician immigration policies, mainly “Immigration backlog.”

Conclusion:

The existing programs to recruit physicians to underserved areas seem to be inadequate. The state and the hospital systems should be able to utilize the J1 program to its full potential and focus on retaining these physicians after their assigned services. As the challenges of IMGs continue to worsen every day; the medical societies, hospitals, the state and federal government should advocate for policies that resolve these challenges.
Teaching Virtual Job Interview Skills to College Students With IDD Using Literacy-Based Behavioral Interventions
Authors: Downey Angelica , Torres Ayse , Kearney Kelly B. , Brady Michael P. , Katz Joshua
Published: February 2021

College students with intellectual and developmental disabilities (IDD) face challenges searching for jobs, often lacking communication and social skills needed during formal interviews. The COVID-19 pandemic complicates interviews, forcing students to search online and attend virtual interviews. This study used a multiple probe design across participants to examine the acquisition of literacy-based behavioral interventions (LBBIs) on virtual job interviews. Using a video conference platform, students answered interview questions from researchers acting as employers. LBBIs were customized, incorporating students’ input. Results indicated that LBBIs were effective for teaching and maintaining virtual job interview skills, and across novel employers. The findings have implications for using LBBIs to teach virtual job interview skills to students with IDD, and for researchers including these students in remote instruction.
Preparations with catastrophic side effects: A case of neck of femur fracture due to secondary osteoporosis with underlying hip osteonecrosis resulting from chronic jamu consumption
Authors: Looi C , Arumugam M , Liew SK , Firdati MS
Published: February 2021

Jamu is commonly used to treat a variety of health conditions in South East Asia due to its efficacy, affordability and ease of access. Despite its effectiveness, little is known regarding its contents and adverse effects. Recent studies have found evidence of steroids within jamu preparations. Chronic jamu consumption may inadvertently manifest with adverse effects associated with long-term steroid intake. We describe a case of neck of femur fracture due to secondary osteoporosis with underlying hip osteonecrosis resulting from chronic jamu consumption hoping to increase awareness regarding the devastating effects of these preparations.
Can simvastatin reduce COPD exacerbations? A randomised double-blind controlled study
Authors: Schenk Peter , Spiel Alexander O. , Hüttinger Felix , Gmeiner Micheline , Fugger Josefine , Pichler Martina , Pichler Gernot , Schmeikal Susanne , Janistyn Wolfgang , Schügerl Stefan , Sajdik Constantin , Herkner Harald
Published: February 2021

Background

Several studies have shown that statins have beneficial effects in COPD regarding lung function decline, rates and severity of exacerbation, hospitalisation and need for mechanical ventilation.

Methods

We performed a randomised double-blind placebo-controlled single-centre trial of simvastatin at a daily dose of 40 mgversusplacebo in patients with Global Initiative for Chronic Obstructive Lung Disease criteria grades 2–4 at a tertiary care pulmonology department in Austria. Scheduled treatment duration was 12 months and the main outcome parameter was time to first exacerbation.

Results

Overall, 209 patients were enrolled. In the 105 patients taking simvastatin, time to first exacerbation was significantly longer compared to the 104 patients taking placebo: median 341versus140 days (log-rank test p<0.001). Hazard ratio for risk of first exacerbation for the simvastatin group was 0.51 (95% CI 0.34–0.75; p=0.001). Rate of exacerbations was significantly lower with simvastatin: 103 (41%)versus147 (59%) (p=0.003). The annualised exacerbation rate was 1.45 events per patient-year in the simvastatin group and 1.9 events per patient-year in the placebo group (incidence rate ratio 0.77, 95% CI 0.60–0.99). We found no effect on quality of life, lung function, 6-min walk test and high-sensitivity C-reactive protein. More patients dropped out in the simvastatin group compared to the placebo group (39versus29).

Conclusion

In our single-centre RCT, simvastatin at a dose of 40 mg daily significantly prolonged time to first COPD exacerbation and reduced exacerbation rate.
Point-of-care lung ultrasound assessment for risk stratification and therapy guiding in COVID-19 patients: a prospective noninterventional study
Authors: Rubio-Gracia Jorge , Giménez-López Ignacio , Garcés-Horna Vanesa , López-Delgado Daniel , Sierra-Monzón Jose Luis , Martínez-Lostao Luis , Josa-Laorden Claudia , Ruiz-Laiglesia Fernando , Pérez-Calvo Juan Ignacio , Crespo-Aznarez Silvia , García-Lafuente Javier , Peña Fresneda Natacha , Amores Arriaga Beatriz , Gracia-Tello Borja , Sánchez-Marteles Marta
Published: February 2021

Background

Lung ultrasound is feasible for assessing lung injury caused by coronavirus disease 2019 (COVID-19). However, the prognostic meaning and time-line changes of lung injury assessed by lung ultrasound in COVID-19 hospitalised patients are unknown.

Methods

Prospective cohort study designed to analyse prognostic value of lung ultrasound in COVID-19 patients by using a quantitative scale (lung ultrasound Zaragoza (LUZ)-score) during the first 72 h after admission. The primary end-point was in-hospital death and/or admission to the intensive care unit. Total length of hospital stay, increase of oxygen flow and escalation of medical treatment during the first 72 h were secondary end-points.

Results

130 patients were included in the final analysis; mean±sdage was 56.7±13.5 years. Median (interquartile range) time from the beginning of symptoms to admission was 6 (4–9) days. Lung injury assessed by LUZ-score did not differ during the first 72 h (21 (16–26) points at admissionversus20 (16–27) points at 72 h; p=0.183). In univariable logistic regression analysis, estimated arterial oxygen tension/inspiratory oxygen fraction ratio (PAFI) (hazard ratio 0.99, 95% CI 0.98–0.99; p=0.027) and LUZ-score >22 points (5.45, 1.42–20.90; p=0.013) were predictors for the primary end-point.

Conclusions

LUZ-score is an easy, simple and fast point-of-care ultrasound tool to identify patients with severe lung injury due to COVID-19, upon admission. Baseline score is predictive of severity along the whole period of hospitalisation. The score facilitates early implementation or intensification of treatment for COVID-19 infection. LUZ-score may be combined with clinical variables (as estimated by PAFI) to further refine risk stratification.
Photocatalytic, Bactericidal and Molecular Docking Analysis of Annealed Tin Oxide Nanostructures
Authors: Sharif Muhammad Shahid , Aqeel Muhammad , Haider Ali , Naz Sadia , Ikram Muhammad , Ul-Hamid Anwar , Haider Junaid , Aslam Irfan , Nazir Asma , Butt Alvina Rafiq
Published: February 2021

Nanosized tin oxide was fabricated with a simple and cost-effective precipitation technique and was analyzed by performing x-ray powder diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, high-resolution transmission electron (HR-TEM) microscopy, energy-dispersive x-ray (EDX) and UV–Vis spectroscopy. The XRD results revealed that tin oxide particles possessed typical orthorhombic structure and exhibited improved crystallinity with annealing. Calcination at 250 °C produced predominantly orthorhombic SnO which transformed to SnO2at higher temperatures of 500 and 750 °C. HRTEM and FESEM images showed existence of agglomeration within the particles of tin oxide. The absorption was found to increase up to a certain annealing temperature followed by a decrease, which was recorded via UV–Vis spectroscopy. The effect of annealing temperature on dye decomposition behavior of synthesized photocatalysts was studied. It was noted that annealing temperature affects the size of synthesized particles, band gap width and photoactivity of tin oxide. The sample prepared at 500 °C followed first-order kinetics and exhibited maximum photocatalytic reactivity toward methylene blue. The experimental results obtained from the present study indicate that SnO2is a promising and beneficial catalyst to remove contaminants from wastewater and environment. The antimicrobial evaluation of SnO annealed at 500 °C against selected targets such asE. coliandS. aureusdepicted significant inhibition zones in comparison with 250 and 750 °C samples. Furthermore, molecular docking predictions of SnO2nanoparticles (NPs) were performed against active pocket ofβ-lactamase and DNA gyrase enzyme belonging to cell wall and nucleic acid biosynthetic pathway, respectively. The fabricated NPs showed good binding score againstβ-lactamase of bothE. coli(− 5.71 kcal/mol) andS. aureus(− 11.83 kcal/mol) alongside DNA gyrase (− 9.57 kcal/mol;E. coliand − 8.61 kcal/mol;S. aureus). These in silico predictions suggested SnO2NPs as potential inhibitors for selected protein targets and will facilitate to have a clear understanding of their mechanism of action that may contribute toward new antibiotics discovery.
Procedural times in early non-intubated VATS program - a propensity score analysis
Authors: Metelmann Isabella , Broschewitz Johannes , Pietsch Uta-Carolin , Huschak Gerald , Eichfeld Uwe , Bercker Sven , Kraemer Sebastian
Published: February 2021

Background

Non-intubated video-assisted thoracic surgery (NiVATS) has been introduced to surgical medicine in order to reduce the invasiveness of anesthetic procedures and avoid adverse effects of intubation and one-lung ventilation (OLV). The aim of this study is to determine the time effectiveness of a NiVATS program compared to conventional OLV.

Methods

This retrospective analysis included all patients in Leipzig University Hospital that needed minor VATS surgery between November 2016 and October 2019 constituting a NiVATS (n = 67) and an OLV (n = 36) group. Perioperative data was matched via propensity score analysis, identifying two comparable groups with 23 patients. Matched pairs were compared via t-Test.

Results

Patients in NiVATS and OLV group show no significant differences other than the type of surgical procedure performed. Wedge resection was performed significantly more often under NiVATS conditions than with OLV (p = 0,043). Recovery time was significantly reduced by 7 min (p = 0,000) in the NiVATS group. There was no significant difference in the time for induction of anesthesia, duration of surgical procedure or overall procedural time.

Conclusions

Recovery time was significantly shorter in NiVATS, but this effect disappeared when extrapolated to total procedural time. Even during the implementation phase of NiVATS programs, no extension of procedural times occurs.
Examining the effectiveness of telemonitoring with routinely acquired blood pressure data in primary care: challenges in the statistical analysis
Authors: Parker Richard A. , Padfield Paul , Hanley Janet , Pinnock Hilary , Kennedy John , Stoddart Andrew , Hammersley Vicky , Sheikh Aziz , McKinstry Brian
Published: February 2021

Background

Scale-up BP was a quasi-experimental implementation study, following a successful randomised controlled trial of the roll-out of telemonitoring in primary care across Lothian, Scotland. Our primary objective was to assess the effect of telemonitoring on blood pressure (BP) control using routinely collected data. Telemonitored systolic and diastolic BP were compared with surgery BP measurements from patients not using telemonitoring (comparator patients). The statistical analysis and interpretation of findings was challenging due to the broad range of biases potentially influencing the results, including differences in the frequency of readings, ‘white coat effect’, end digit preference, and missing data.

Methods

Four different statistical methods were employed in order to minimise the impact of these biases on the comparison between telemonitoring and comparator groups. These methods were “standardisation with stratification”, “standardisation with matching”, “regression adjustment for propensity score” and “random coefficient modelling”. The first three methods standardised the groups so that all participants provided exactly two measurements at baseline and 6–12 months follow-up prior to analysis. The fourth analysis used linear mixed modelling based on all available data.

Results

The standardisation with stratification analysis showed a significantly lower systolic BP in telemonitoring patients at 6–12 months follow-up (-4.06, 95% CI -6.30 to -1.82, p < 0.001) for patients with systolic BP below 135 at baseline. For the standardisation with matching and regression adjustment for propensity score analyses, systolic BP was significantly lower overall (− 5.96, 95% CI -8.36 to − 3.55 , p < 0.001) and (− 3.73, 95% CI− 5.34 to − 2.13, p < 0.001) respectively, even after assuming that − 5 of the difference was due to ‘white coat effect’. For the random coefficient modelling, the improvement in systolic BP was estimated to be -3.37 (95% CI -5.41 to -1.33 , p < 0.001) after 1 year.

Conclusions

The four analyses provide additional evidence for the effectiveness of telemonitoring in controlling BP in routine primary care. The random coefficient analysis is particularly recommended due to its ability to utilise all available data. However, adjusting for the complex array of biases was difficult. Researchers should appreciate the potential for bias in implementation studies and seek to acquire a detailed understanding of the study context in order to design appropriate analytical approaches.
There is still room for improvement in the completeness of abstract reporting according to the PRISMA-A checklist: a cross-sectional study on systematic reviews in periodontology
Authors: Adobes Martin Milagros , Santamans Faustino Sala , Llario Almiñana Inmaculada , Aiuto Riccardo , Rotundo Roberto , Garcovich Daniele
Published: February 2021

Background

To evaluate the completeness of reporting abstracts of systematic reviews (SRs) before and after the publication of the PRISMA-A checklist in 2013 and to assess if an association exists between abstract characteristics and the completeness of reporting.

Methods

A systematic search of the literature was conducted in the PubMed and Scopus databases in March 2020. The search focused on the SRs of evaluations of interventions published since 2002 in the field of periodontology. The abstracts of the selected SRs were divided into two groups before and after publication of the PRISMA-A checklist in 2013, and compliance with the 12 items reported in the checklist was evaluated by three calibrated evaluators.

Results

A set of 265 abstracts was included in the study. The total score before (mean score, 53.78%; 95% CI, 51.56–55.90%) and after (mean score, 56.88%; 95% CI, 55.39–58.44%) the publication of the PRISMA-A statement exhibited a statistically significant improvement (P = 0.012*). Nevertheless, only the checklist items included studies and synthesis of the results displayed a statistically significant change after guideline publication. The total PRISMA-A score was higher in the meta-analysis group and in articles authored by more than four authors.

Conclusions

The impact of the PRISMA-A was statistically significant, but the majority of the items did not improve after its introduction. The editors and referees of periodontal journals should promote adherence to the checklist to improve the quality of the reports and provide readers with better insight into the characteristics of published studies.
Inferencing superspreading potential using zero-truncated negative binomial model: exemplification with COVID-19
Authors: Zhao Shi , Shen Mingwang , Musa Salihu S. , Guo Zihao , Ran Jinjun , Peng Zhihang , Zhao Yu , Chong Marc K. C. , He Daihai , Wang Maggie H.
Published: February 2021

Background

In infectious disease transmission dynamics, the high heterogeneity in individual infectiousness indicates that few index cases generate large numbers of secondary cases, which is commonly known as superspreading events. The heterogeneity in transmission can be measured by describing the distribution of the number of secondary cases as a negative binomial (NB) distribution with dispersion parameter, k. However, such inference framework usually neglects the under-ascertainment of sporadic cases, which are those without known epidemiological link and considered as independent clusters of size one, and this may potentially bias the estimates.

Methods

In this study, we adopt a zero-truncated likelihood-based framework to estimate k. We evaluate the estimation performance by using stochastic simulations, and compare it with the baseline non-truncated version. We exemplify the analytical framework with three contact tracing datasets of COVID-19.

Results

We demonstrate that the estimation bias exists when the under-ascertainment of index cases with 0 secondary case occurs, and the zero-truncated inference overcomes this problem and yields a less biased estimator of k. We find that the k of COVID-19 is inferred at 0.32 (95%CI: 0.15, 0.64), which appears slightly smaller than many previous estimates. We provide the simulation codes applying the inference framework in this study.

Conclusions

The zero-truncated framework is recommended for less biased transmission heterogeneity estimates. These findings highlight the importance of individual-specific case management strategies to mitigate COVID-19 pandemic by lowering the transmission risks of potential super-spreaders with priority.
Constitutional mismatch repair deficiency in childhood colorectal cancer harboring a de novo variant in the MSH6 gene: a case report
Authors: Hizuka Keinosuke , Hagiwara Shin-ichiro , Maeyama Takatoshi , Honma Hitoshi , Kawai Masanobu , Akagi Kiwamu , Yasuhara Michiko , Tomita Naohiro , Etani Yuri
Published: February 2021

Background

Constitutional mismatch repair deficiency (CMMRD) is caused by biallelic pathogenic variants in one of the mismatch repair genes, and results in early onset colorectal cancer, leukemia, brain tumors and other childhood malignancies. Here we report a case of CMMRD with compound heterozygous variants in the MSH6 gene, including a de novo variant in multiple colorectal cancers.

Case presentation

An 11-year-old girl, who presented with multiple spots resembling café-au-lait macules since birth, developed abdominal pain, diarrhea and bloody stool over two months. Colonoscopy revealed multiple colonic polyps, including a large epithelial tumor, and pathological examination revealed tubular adenocarcinoma. Brain magnetic resonance imaging (MRI) showed an unidentified bright object (UBO), commonly seen in neurofibromatosis type 1 (NF1). Genetic testing revealed compound heterozygous variants, c. [2969T > A (p.Leu990*)] and [3064G > T (p.Glu1022*)] in the MSH6 gene; c.2969T > A (p.Leu990*) was identified as a de novo variant.

Conclusions

We present the first report of a CMMRD patient with a de novo variant in MSH6, who developed colorectal cancer in childhood. CMMRD symptoms often resemble NF1, as observed here. Physicians should become familiar with CMMRD clinical phenotypes for the screening and early detection of cancer.
Utilization of potentially inappropriate medication and risk of adverse drug events among older adults with chronic renal insufficiency: a population-wide cohort study
Authors: Sheikh Rezaei Safoura , Šinkovec Hana , Schöberl Alexander , Rinner Christoph , Heinze Georg , Wolzt Michael , Gall Walter
Published: February 2021

Background

The use of potentially inappropriate medication (PIM) in population of older adults may result in adverse drug events (ADE) already after short term exposure, especially when it is prescribed to patients with chronic kidney disease (CKD). In order to limit ADE in the treatment of older adults PIM lists have been constructed as a source of information for healthcare professionals. The aim of this study was to estimate the utilization of PIM and incidence of ADE in older adults (≥70 years) with CKD.

Methods

We conducted a retrospective population-wide cohort study including patients from Lower Austria who were 70 years or older and diagnosed with CKD in the period from 2008 to 2011. Utilization of PIM was estimated from prescriptions filled by target population. We estimated risks of hospitalization due to ADE within 30 days after incident PIM prescription and compared them to a PIM-free control group by using marginal structural models (MSM).

Results

We identified 11,547 patients (women: 50.6%, median age in 2008: 78 years) who fulfilled the inclusion criteria. In total 24.7 and 8.1% of all prescriptions from that period contained a medication with a substance listed in the EU (7)-PIM and AT-PIM list, respectively. Proton pump inhibitors andGinkgo bilobawere the most often prescribed PIMs in this population. 94.6 and 79.3% patients filled at least one EU(7)-PIM and AT-PIM prescription, respectively. Despite the relatively high utilization of PIM there was only a low incidence of clinically relevant ADE. No event type exceeded the threshold level of 1% in the analysis of risks of ADE after filling a prescription for PIM. Nevertheless, MSM analysis showed an increased risk for 11 drugs and reduced risk for 4 drugs.

Conclusions

PIM prescription was common among older adults with CKD, however, only a small number of these drugs eventually led to hospitalization due to ADE within 30 days after incident PIM was filled. In the absence of a clinically important PIM-related increase in risk, an assessment of potential ADE severity to a PIM list by using a warning score system seems prudent.
Assessing fidelity of a community based psychosocial intervention for people with mild dementia within a large randomised controlled trial
Authors: Sprange Kirsty , Beresford-Dent Jules , Mountain Gail , Craig Claire , Mason Clare , Berry Katherine , Wright Jessica , Majid Shazmin , Thomas Ben , Cooper Cindy L.
Published: February 2021

Background

Understanding intervention delivery as intended, particularly in complex interventions, should be underpinned by good quality fidelity assessment. We present the findings from a fidelity assessment embedded as part of a trial of a complex community-based psychosocial intervention, Journeying through Dementia (JtD). The intervention was designed to equip individuals with the knowledge and skills to successfully self-manage, maintain independence, and live well with dementia and involves both group and individual sessions. The methodological challenges of developing a conceptual framework for fidelity assessment and creating and applying purposely designed measures derived from this framework are discussed to inform future studies.

Methods

A conceptual fidelity framework was created out of core components of the intervention (including the intervention manual and training for delivery), associated trial protocols and pre-defined fidelity standards and criteria against which intervention delivery and receipt could be measured. Fidelity data collection tools were designed and piloted for reliability and usability. Data collection in four selected sites (fidelity sites) was via non-participatory observations of the group aspect of the intervention, attendance registers and interventionist (facilitator and supervisor) self-report.

Results

Interventionists from all four fidelity sites attended intervention training. The majority of group participants at the four sites (71%) received the therapeutic dose of 10 out of 16 sessions. Weekly group meeting attendance (including at ‘out of venue’ sessions) was excellent at 80%. Additionally, all but one individual session was attended by the participants who completed the intervention. It proved feasible to create tools derived from the fidelity framework to assess in-venue group aspects of this complex intervention. Results of fidelity assessment of the observed groups were good with substantial inter-rater reliability between researchers KAPPA 0.68 95% CI (0.58–0.78). Self-report by interventionists concurred with researcher assessments.

Conclusions

There was good fidelity to training and delivery of the group aspect of the intervention at four sites. However, the methodological challenges of assessing all aspects of this complex intervention could not be overcome due to practicalities, assessment methods and ethical considerations. Questions remain regarding how we can assess fidelity in community-based complex interventions without impacting upon intervention or trial delivery.

Trial registration

ISRCTN17993825.