bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrasonography Combined With Contrast-enhanced Ultrasonography Can Predict Lymphocyte-predominant Breast Cancer
Authors: FUKUI KAYO , MASUMOTO NORIO , YOKOYAMA ERIKA , KANOU AKIKO , YOKOZAKI MICHIYA , SASADA SHINSUKE , EMI AKIKO , KADOYA TAKAYUKI , ARIHIRO KOJI , OKADA MORIHITO
Published: November 2021

Background: We investigated whether contrast-enhanced ultrasonography (CEUS) scores can predict lymphocyte-predominant breast cancer (LPBC). Patients and Methods: We evaluated 75 patients who underwent US and CEUS. LPBC was defined as tissues with ≥50% stromal tumour-infiltrating lymphocytes (TILs) preoperatively. Characteristic US images predicting LPBC were evaluated using TIL-US scores via three ultrasonic tissue characteristics: Shape, internal echo level, and posterior echoes. TIL-CEUS was evaluated based on TIL-US plus CEUS. Results: TIL-US and TIL-CEUS cut-offs for predicting LPBC were 4 and 6 (area under the curve=0.93 and 0.96, respectively) points based on receiver operating characteristics curves. Sensitivity, specificity, and accuracy values (95% confidence intervaI) were 0.94 (0.77-0.99), 0.75 (0.70-0.77), and 0.80 (0.72-0.82); and 0.94 (0.78-0.99), 0.86 (0.81-0.87), and 0.88 (0.80-0.90) for TIL-US and TIL-CEUS, respectively. TIL-CEUS score was a significant single predictor for LPBC in multivariate logistic regression (p=0.001). Conclusion: TIL-CEUS can be used for preoperative LPBC prediction and detection.
Correlation Between the Transient Elevation of Peripheral Eosinophil Count During Radiotherapy and Acute Diarrhea
Authors: KOBAYASHI TAKAKO , ISOHASHI FUMIAKI , EINO DAISUKE , TANAKA KAZUNORI , SAWADA KENJIRO , UEDA YUTAKA , KOBAYASHI EIJI , TOMIMATSU TAKUJI , KIMURA TADASHI , OGAWA KAZUHIKO
Published: November 2021

Background/Aim: This study aimed to evaluate the association between the change in peripheral eosinophil count during postoperative pelvic radiotherapy and gastrointestinal (GI) toxicities in patients with cervical cancer. Patients and Methods: The medical records of 163 patients with cervical cancer who underwent postoperative concurrent chemoradiotherapy between 2000 and 2016 were analyzed. Results: Among the peripheral blood cell counts, transient elevation of the eosinophil count was observed during radiotherapy. Of the 163 patients, 117 developed grade ≥2 diarrhea during radiotherapy, and 25 patients developed grade ≥2 late GI toxicities. In multivariate analysis, the maximum eosinophil count and age emerged as independent predictors of grade ≥2 acute diarrhea during radiotherapy, while bowel bag V40 Gy and age were predictive of grade ≥2 late GI toxicities. Conclusion: Early detection of transient elevation of eosinophil may facilitate early treatment of acute diarrhea during radiotherapy.
The Clinical Features of Multicentric Extra-abdominal Desmoid Tumors
Authors: MINAMI YUSUKE , MATSUMOTO SEIICHI , AE KEISUKE , TANIZAWA TAISUKE , HAYAKAWA KEIKO , SAITO MASANORI , KUROSAWA NORIO
Published: November 2021

Background: Extra-abdominal desmoid tumors often occur in the necks, shoulder, chest wall, back, arm, buttock, thigh and leg. Multicentric extra-abdominal desmoids are rather rare and seem to have other clinical features. The aim of our study was to investigate clinical features, especially multicentric occurrence of extra-abdominal desmoid tumors. Patients and Methods: A total of 135 patients diagnosed with extra-abdominal desmoid were enrolled in this study from January 2005 to December 2019 at the Cancer Institute Hospital of The Japanese Foundation for Cancer Research. The operative procedure was principally wide excision. The clinicopathological factors [e.g., age, gender, pain, restriction of range of motion (ROM), tumor site, tumor size, surgical margin, multicentric occurrence, local recurrence, tumoral regression] were collected and assessed by univariate analysis. We assessed how multicentric occurrence influenced clinicopathological factors of desmoid tumors. Results: The median follow-up was 39.9 months (range=0.29-259 months). Among 135 patients, 20 had multicentric occurrence. Multicentric extra-abdominal desmoids occurred in the neck in six cases, shoulder in four, chest wall in three, back in three, thigh in two and leg in two. In the case of multicentric occurrence on thighs and legs, tumors arose not in the anterior compartment but in the posterior compartment. Univariate analysis showed association of multicentric extra-abdominal desmoids with high local recurrence (p=0.0003), restriction of ROM (p=0.0012) and tumor size larger than 5 cm (p=0.04) but surgical margins were not correlated with local recurrence (p=0.37). Conclusion: Surgery should be performed in those who have severe pain or restriction of ROM. A 'Wait and see' policy is a first-line management, especially for those with multicentric extra-abdominal desmoids.
Diarrhea in Placebo Arms of Cancer Studies
Authors: WOLFF BIRTE J. , WOLFF JOHANNES E.
Published: November 2021

Background/Aim: Diarrhea is among the most common adverse events in early oncology clinical trials, and drug causality may be difficult to determine. Materials and Methods: This is a systematic literature review of placebo arms of randomized cancer trials. Results: Anemia was reported in 95 of 127 placebo monotherapy cohorts. Publications involving healthy volunteers and cancer prevention studies reported lower frequencies than those with cancer patients. The average reported frequency of diarrhea grade 1 or higher among studies in cancer patients was 15%. The maximal reported frequencies for grades 1, 2, 3, 4, 5 were 56, 24, 6, 2, and 0%, respectively. Conclusion: When higher diarrhea frequencies than those are observed in treatment arms of clinical trials, then drug causality is likely.
Absolute Lymphocyte Count, Platelet-to-Lymphocyte Ratio, and Overall Survival in Eribulin-treated HER2-negative Metastatic Breast Cancer Patients
Authors: KOYAMA YOICHI , KAWAI SAORI , UENAKA NATSUKI , OKAZAKI MIKI , ASAOKA MARIKO , TERAOKA SAEKO , UEDA AI , MIYAHARA KANA , KAWATE TAKAHIKO , KAISE HIROSHI , YAMADA KIMITO , ISHIKAWA TAKASHI
Published: November 2021

Background/Aim: To investigate the utility of peripheral blood biomarkers – absolute lymphocyte count (ALC), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) – for predicting outcomes in eribulin-treated patients with metastatic human epidermal growth factor receptor type 2 (HER2)-negative breast cancer. Patients and Methods: ALC, NLR, and PLR were retrospectively obtained from pre-treatment blood sampling results of 120 patients and stratified according to means. Univariate and multivariate analyses were performed to investigate the association of clinicopathological factors, including these values, with overall survival (OS) and progression-free survival (PFS). Results: The ALC, NLR, and PLR cut-off points were 1,285/μl, 3.3, and 235, respectively. No biomarkers were associated with PFS. However, univariate analysis showed ALC (p=0.044) and PLR (p=0.044) to be significantly associated with OS. Conclusion: ALC and PLR can predict eribulin efficacy in terms of OS, reflecting the antitumour immune response in the microenvironment and indicating eribulin’s effectiveness.
Efficacy of Combination Chemotherapy With Docetaxel, Estramustine and Carboplatin in Men With Castration-resistant Prostate Cancer
Authors: HIKITA KATSUYA , HONDA MASASHI , SHIMIZU RYUTARO , TERAOKA SHOGO , KAWAMOTO BUNYA , YUMIOKA TETSUYA , TSOUNAPI PANAGIOTA , IWAMOTO HIDETO , MORIZANE SHUICHI , TAKENAKA ATSUSHI
Published: November 2021

Background: The efficacy of docetaxel and carboplatin with oral estramustine was evaluated in patients with castration-resistant prostate cancer. Patients and Methods: Patients were treated with intravenous docetaxel at 30 mg/m2 on days 1, 8, 15, and 22 of a 28-day cycle. Intravenous carboplatin (area under the curve, 6 mg/ml/min) was administered on day 1. Patients received oral estramustine at 626.8 mg/day throughout the treatment protocol. Patients were evaluated for response, with treatment continued until cancer progression or onset of severe adverse events. Results: Twenty patients with castration-resistant prostate cancer were treated for a median of 3.5 cycles. Prostate-specific antigen decreased by more than 30% in 18 patients, including 14 patients with a decrease of more than 50%. Median overall survival was 11 months, prostate-specific antigen progression-free survival was 6.5 months, and radiographic progression-free survival was 7 months. Conclusion: Docetaxel and carboplatin with oral estramustine shows efficacy against castration-resistant prostate cancer.
The Systemic Immune Markers at Diagnosis Can Predict the Survival Benefit in Advanced Breast Cancer
Authors: NAKAMOTO SHOGO , IKEDA MASAHIKO , KUBO SHINICHIRO , YAMAMOTO MARI , YAMASHITA TETSUMASA , KUWAHARA CHIHIRO
Published: November 2021

Background/Aim: It has been difficult to establish prognostic markers for overall survival (OS) in patients with advanced breast cancer (ABC). Although systemic immune markers were reported as prognostic markers in several cancers, their utility in ABC remains unclear. Patients and Methods: We retrospectively analyzed 331 ABC patients, who received treatment at Fukuyama City Hospital between April 2009 and December 2020. Results: Patients with high absolute lymphocyte count (ALC), low neutrophil-to-lymphocyte ratio (NLR), and high lymphocyte-to-monocyte ratio (LMR) had significantly longer OS (p=0.025, p=0.010, and p<0.001, respectively). High ALC and high LMR were independently associated with longer OS (p=0.020 and p=0.015, respectively). High ALC was also independently associated with longer time to treatment failure (p=0.014). Conclusion: These systemic immune markers at diagnosis can predict not only a better OS but also a better TTF after first-line treatment.
Absolute Increase in the Number and Proportion of Peripheral Eosinophils Associated With Immune Checkpoint Inhibitor Treatment in Non-small Cell Lung Cancer Patients
Authors: OSAWA HAJIME , SHIOZAWA TOSHIHIRO , OKAUCHI SHINICHIRO , SASATANI YUIKA , OHARA GEN , SATO SHINYA , MIYAZAKI KUNIHIKO , KODAMA TAKAHIDE , KAGOHASHI KATSUNORI , SATOH HIROAKI , HIZAWA NOBUYUKI
Published: November 2021

Background/Aim: To clarify the clinical significance of the absolute increase in the number and proportion of peripheral eosinophils associated with immune checkpoint inhibitor (ICPI) treatment in non-small cell lung cancer (NSCLC) patients. Patients and Methods: We performed a retrospective study, by reviewing the medical charts of 191 patients who were treated with ICPI monotherapy and 80 patients treated with the combination of ICPI and chemotherapy during the period from February 2016 and April 2021. Results: In patients treated with ICPI monotherapy, there was a significant difference in time to treatment failure (TTF) between the two groups divided by eosinophils ≥ or <10%. Similarly, a significant difference was found in TTF between the two groups divided by eosinophils ≥ or <1,500/μl. Factors related to both an increase in the number and percentage of peripheral eosinophils were “immune-related adverse effects (irAE) that did not lead to discontinuation of administration". Conclusion: Some patients with irAE might have a 'favorable' absolute increase in peripheral eosinophils.
Undifferentiated Carcinoma After Laparoscopic Surgery for a Cystic Ovarian Tumour: A Case Study
Authors: SHIGEMATSU KOSUKE , SAMEJIMA KOKI , SAWADA KEISUKE , UOTANI TAKAHIRO , AKAHORI TAICHI , MATSUNAGA SHIGETAKA , NAGAI TOMONORI , TAMARU JUN-ICHI , TAKAI YASUSHI
Published: November 2021

Background: Laparoscopic surgery for malignant tumours occasionally results in recurrence at the trocar insertion site or port-site metastasis (PSM). We report on a patient requiring emergency laparoscopic surgery for an ovarian tumour with a review of the relevant literature. Case Report: A 42-year-old woman developed sudden abdominal pain and underwent laparoscopic right adnexectomy because of a suspected ovarian cystic tumour rupture. The postoperative histological diagnosis was a mucinous borderline ovarian tumour; however, an undifferentiated carcinoma was detected at the port site eight months after the initial surgery. The histopathological diagnosis of the abdominal wall tumour at the port site differed from intraoperative pathological findings, which was contradictory to PSM definition. Postoperatively, she received three systemic chemotherapy courses but died consequent to tumour metastasis. Conclusion: This is an atypical PSM case with histopathological differences from the initial tumour. Careful preoperative diagnosis and intraoperative attention are essential in such cases.
Body Image Distress and Its Associations From an International Sample of Men and Women Across the Adult Life Span: Web-Based Survey Study
Authors: Milton Alyssa , Hambleton Ashlea , Roberts Anna , Davenport Tracey , Flego Anna , Burns Jane , Hickie Ian
Published: November 2021

Background

Previous research on body image distress mainly relied on samples that were small, generally homogeneous in age or sex, often limited to one geographical region, and were characterized by a lack of comprehensive analysis of multiple psychosocial domains. The research presented in this paper extends the international literature using the results of the web-based Global Health and Wellbeing Survey 2015. The survey included a large sample of both men and women aged ≥16 years from Australia, Canada, New Zealand, the United Kingdom, or the United States.

Objective

The main objectives of this study are to examine body image distress across the adult life span (≥16 years) and sex and assess the association between body image distress and various psychosocial risk and protective factors.

Methods

Data were extracted from the Global Health and Wellbeing Survey 2015, a web-based international self-report survey with 10,765 respondents, and compared with previous web-based surveys conducted in 2009 and 2012.

Results

The body image distress of young Australians (aged 16-25 years) significantly rose by 33% from 2009 to 2015. In 2015, 75.19% (961/1278) of 16- to 25-year-old adults reported body image distress worldwide, and a decline in body image distress was noted with increasing age. More women reported higher levels of body image distress than men (1953/3338, 58.51% vs 853/2175, 39.22%). Sex, age, current dieting status, perception of weight, psychological distress, alcohol and other substance misuse, and well-being significantly explained 24% of the variance in body image distress in a linear regression (F15,4966=105.8; P<.001).

Conclusions

This study demonstrates the significant interplay between body image distress and psychosocial factors across age and sex.
Web-Based Eye Movement Desensitization and Reprocessing for Adults With Suicidal Ideation: Protocol for a Randomized Controlled Trial
Authors: Winkler Olga , Dhaliwal Raman , Greenshaw Andrew , O'Shea Katie , Abba-Aji Adam , Chima Chidi , Purdon Scot E , Burback Lisa
Published: November 2021

Background

Adversity and traumatic experiences increase the likelihood of suicidal thoughts and behaviors. Eye Movement Desensitization and Reprocessing (EMDR) is an evidence-based, trauma-focused psychotherapy that desensitizes painful memories, so that reminders in the present no longer provoke overwhelming emotional responses. Preliminary evidence suggests that EMDR can be used as an acute intervention in suicidal patients, including those with major depressive disorder. In addition, because of social distancing restrictions during the COVID-19 pandemic, clinicians have been using EMDR on the web and, in the absence of formal evaluations of web-based EMDR, informal reports indicate good results.

Objective

The primary aim of this randomized controlled trial is to investigate whether remotely delivered EMDR (targeting experiences associated with suicidal thinking) reduces suicidal thoughts. Secondary aims include examining the impact of remotely delivered EMDR on symptoms of depression, anxiety, posttraumatic stress, emotional dysregulation, and dissociation. We will also report on adverse events in the EMDR group to explore whether targeting suicidal ideation with EMDR is safe. Finally, we will compare dropout rates between the treatment groups.

Methods

In this randomized controlled trial, 80 adults who express suicidal ideation and meet the study criteria will receive either 12 sessions of twice weekly EMDR plus treatment as usual or treatment as usual alone. EMDR sessions will focus on the most distressing and intrusive memories associated with suicidal ideation. Data for primary and secondary objectives will be collected at baseline, 2 months, and 4 months after enrollment. A subsequent longer-term analysis, beyond the scope of this protocol, will examine differences between the groups with respect to the number of posttreatment emergency room visits, hospitalizations, and overall health care use in the year before and after therapy.

Results

The protocol was approved by the University of Alberta Research Health Ethics Board (protocol ID Pro00090989). Funding for this study was provided by the Mental Health Foundation (grant RES0048906). Recruitment started in May 2021, with a projected completion date of March 2023.

Conclusions

The results of this trial will contribute to knowledge on whether web-based delivery of EMDR is a safe and effective treatment for reducing suicidal ideation and potentially reducing the incidence of suicide attempts in this patient population.

Trial Registration

ClinicalTrials.gov NCT04181047; https://clinicaltrials.gov/ct2/show/NCT04181047

International Registered Report Identifier (IRRID)

DERR1-10.2196/30711
COVID-19 Outcomes and Genomic Characterization of SARS-CoV-2 Isolated From Veterans in New England States: Retrospective Analysis
Authors: Lee Megan , Sallah Ya Haddy , Petrone Mary , Ringer Matthew , Cosentino Danielle , Vogels Chantal B F , Fauver Joseph R , Alpert Tara D , Grubaugh Nathan D , Gupta Shaili
Published: November 2021

Background

Clinical and virologic characteristics of COVID-19 infections in veterans in New England have not been described. The average US veteran is a male older than the general US population. SARS-CoV-2 infection is known to cause poorer outcomes among men and older adults, making the veteran population an especially vulnerable group for COVID-19.

Objective

This study aims to evaluate clinical and virologic factors impacting COVID-19 outcomes.

Methods

This retrospective chart review included 476 veterans in six New England states with confirmed SARS-CoV-2 infection between April and September 2020. Whole genome sequencing was performed on SARS-CoV-2 RNA isolated from these veterans, and the correlation of genomic data to clinical outcomes was evaluated. Clinical and demographic variables were collected by manual chart review and were correlated to the end points of peak disease severity (based on oxygenation requirements), hospitalization, and mortality using multivariate regression analyses.

Results

Of 476 veterans, 274 had complete and accessible charts. Of the 274 veterans, 92.7% (n=254) were men and 83.2% (n=228) were White, and the mean age was 63 years. In the multivariate regression, significant predictors of hospitalization (C statistic 0.75) were age (odds ratio [OR] 1.05, 95% CI 1.03-1.08) and non-White race (OR 2.39, 95% CI 1.13-5.01). Peak severity (C statistic 0.70) also varied by age (OR 1.07, 95% CI 1.03-1.11) and O2 requirement on admission (OR 45.7, 95% CI 18.79-111). Mortality (C statistic 0.87) was predicted by age (OR 1.06, 95% CI 1.01-1.11), dementia (OR 3.44, 95% CI 1.07-11.1), and O2 requirement on admission (OR 6.74, 95% CI 1.74-26.1). Most (291/299, 97.3%) of our samples were dominated by the spike protein D614G substitution and were from SARS-CoV-2 B.1 lineage or one of 37 different B.1 sublineages, with none representing more than 8.7% (26/299) of the cases.

Conclusions

In a cohort of veterans from the six New England states with a mean age of 63 years and a high comorbidity burden, age was the largest predictor of hospitalization, peak disease severity, and mortality. Non-White veterans were more likely to be hospitalized, and patients who required oxygen on admission were more likely to have severe disease and higher rates of mortality. Multiple SARS-CoV-2 lineages were distributed in patients in New England early in the COVID-19 era, mostly related to viruses from New York State with D614G mutation.
Validation of a Musculoskeletal Digital Assessment Routing Tool: Protocol for a Pilot Randomized Crossover Noninferiority Trial
Authors: Lowe Cabella , Hanuman Sing Harry , Marsh William , Morrissey Dylan
Published: November 2021

Background

Musculoskeletal conditions account for 16% of global disability, resulting in a negative effect on millions of patients and an increasing demand for health care use. Digital technologies to improve health care outcomes and efficiency are considered a priority; however, innovations are rarely tested with sufficient rigor in clinical trials, which is the gold standard for clinical proof of safety and efficacy. We have developed a new musculoskeletal digital assessment routing tool (DART) that allows users to self-assess and be directed to the right care. DART requires validation in a real-world setting before implementation.

Objective

This pilot study aims to assess the feasibility of a future trial by exploring the key aspects of trial methodology, assessing the procedures, and collecting exploratory data to inform the design of a definitive randomized crossover noninferiority trial to assess DART safety and effectiveness.

Methods

We will collect data from 76 adults with a musculoskeletal condition presenting to general practitioners within a National Health Service (NHS) in England. Participants will complete both a DART assessment and a physiotherapist-led triage, with the order determined by randomization. The primary analysis will involve an absolute agreement intraclass correlation (A,1) estimate with 95% CI between DART and the clinician for assessment outcomes signposting to condition management pathways. Data will be collected to allow the analysis of participant recruitment and retention, randomization, allocation concealment, blinding, data collection process, and bias. In addition, the impact of trial burden and potential barriers to intervention delivery will be considered. The DART user satisfaction will be measured using the system usability scale.

Results

A UK NHS ethics submission was done during June 2021 and is pending approval; recruitment will commence in early 2022, with data collection anticipated to last for 3 months. The results will be reported in a follow-up paper in 2022.

Conclusions

This study will inform the design of a randomized controlled crossover noninferiority study that will provide evidence concerning mobile health DART system clinical signposting in an NHS setting before real-world implementation. Success should produce evidence of a safe, effective system with good usability, potentially facilitating quicker and easier patient access to appropriate care while reducing the burden on primary and secondary care musculoskeletal services. This rigorous approach to mobile health system testing could be used as a guide for other developers of similar applications.

Trial Registration

ClinicalTrials.gov NCT04904029; http://clinicaltrials.gov/ct2/show/NCT04904029

International Registered Report Identifier (IRRID)

PRR1-10.2196/31541
A Precis on How Democracies Die as a Consequence of America’s, Failure of Government Working for the People while Serving the Interests of the Wealthy
Authors: Bedell Frederick D.
Published: November 2021

This precis speaks to the failure of the United States government to sustain the wealth of the middle-class after the post-World War Two years’, while serving the wealthiest Americans. It will document how the country has become polarized and fractured along ideological and cultural lines. This situation has created a segmentation of the country that has competing visions, purpose and meaning which is tearing it apart.It will also focus on the inequality in the country that has emerged from the Oligarchy’s domination of the political and free market space-government of the 1%, by the 1% AND FOR THE 1%. Their mantra is to keep the government out of business and have business in the government.
ANALYSIS OF STUDENTS' ABILITY IN WRITING USING NOUN PHRASE ON DESCRIPTIVE TEXT
Authors: Wahyuni Selli , Eliza  , Prima Dewi Merry
Published: November 2021

This research is conducted because the researcher found some problems at the eleventh grade students at SMAN 1 Padang Gelugur in writing. The first problem was some of the students felt reluctant to write in English. The second problem was some of the students had limited vocabulary. And the last problem was some of the students still had difficulties to understand the correct form of using noun phrase. This study aimed to find out the level achivement of students' ability in writing using noun phrase on descriptive text. The design of this research was descriptive quantitative. The population of this research were the eleventh grade students that consist of 111 students. The students were divided into four classes. The number of samples of this research were 27 students. The researcher used purposive sampling technique to determine the sample, because the researcher had some considerations, the reason were:  it is because the students have already learned about noun phrase on descriptive text. Then some of the students did not have a good writing noun phrase on descriptive text. To collect the data, the researcher used writing test. There were 3 indicators of noun phrase. They were head, premodifier and postmodifier. Based on the result of the research, it was found that 54,5% of the students had written noun phrase in ‘head' correctly. Then it was found that 53,6% of the students had written  noun phrase in ‘premodifier' correctly. And it was found 53,5% of the students had written noun phrase in ‘postmodifier' correctly. In conclusion, the students ability in writing using noun phrase based on those three indicators above was 54% which mean the students ability was in fair level. Therefore, based on the result that has been obtained by the researcher, it is concluded that the students still have difficulties using correct form of noun phrase in writing.
ENGLISH LECTURERS' PERCEPTION TOWARD PROFESSIONAL DEVELOPMENT PROGRAMS
Authors: Supraptiningsih Nurhandayani , Warni Silih , Ahmad Zuhad
Published: November 2021

This study aims to explore the experiences and perceptions of lecturers on the professional development activities of lecturers in the English Language Education Study Program. This study applied a quantitative descriptive approach by using a questionnaire as an instrument to collect data. This study's subjects were the lecturers of the English Education Study Program at a private university in Jakarta. The findings indicate that the professional development activities that have been attended by the majority of English Education lecturers are research activities, both individually and in groups, conferences or seminars, and workshops or training related to courses and/or other topics related to education. The professional development activities needed by lecturers include training related to National Education Standards (60%), multicultural teaching (60%), knowledge and understanding (competence) of the subject (53%), and teaching for students with special needs ( 53%). This study also confirms that effective time management for organizing or developing professional development activities regarding teaching schedules and other administrative activities is urgently needed. That way, lecturers can still fulfill their obligations to teach, research, and do community service while still having the opportunity to develop their professionalism.
STUDENTS' PERCEPTIONS TOWARDS THE IMPLEMENTATION OF MALL IN ENGLISH LEARNING: A CASE IN SENIOR HIGH SCHOOL
Authors: Ningrum Adhitias Dewi Helda , Arrasyid Farouk Imam
Published: November 2021

Abstract: In this 21st century era therm of Mobile Assisted Language Learning becomes a part of teaching and learning activity in English Education. Mobile Assisted Language learning offers various benefits to both teachers and students. Though, it offers various benefits, in practice it is still debatable thing. Thus, this research was tried to investigate students' perception towards the implementation of MALL in their learning process. The research was taken at Senior High School in SMAN 1 Dukupuntang. This current study use descriptive qualitative method, and the data were collected through open-ended questionnaires and interview to get the relevant data. The present research shows that students tend to have good perception on the implementation of MALL in English Learning. In using MALL, students use several applications and software to help them study about English Language both inside and outside the classroom. By using MALL, students feel that it was more enjoyable and able to get the information quickly. This research also shows the challenges that faced by the students when they use MALL in English Learning activity. In conclusion, this research shows that students' have positive perception towards MALL in English Learning.
USE OF YOUTUBE TO SUPPORT EFL STUDENTS' LISTENING SKILLS
Authors: Yuyun Ignasia , Simamora Fitri Yanti
Published: November 2021

Authentic material in the English as a Foreign Language (EFL) classroom, particularly in listening,  encourages students to apply actual language or authentic speech. In this digital era, Information and Communication Technology (ICT)  plays a pivotal role for the teacher's resources to support the teaching-learning process in the classroom. The teacher can find free resources on the Internet by browsing Google, Yahoo, and YouTube. Using YouTube videos can improve students' listening comprehension as it brings many benefits to learners. YouTube is a tool of authentic material to support the student to focus more on listening. The teacher needs to encourage student's motivation in the teaching-learning process. Therefore, this study investigates how YouTube Video is a teaching tool to improve student's listening comprehension skills. There were eight participants from the English Department in a private university in Jakarta. The data was collected through class observation and interviews to observe EFL students' progress in the learning process of listening. This study revealed that YouTube video benefits EFL learners, such as improving students' confidence, enjoying the learning process, making the learning process more fun, and increasing students' interest in learning.
USE OF LEARNERS' DIARIES: DOES IT WORK TO ENGAGE STUDENTS' METACOGNITION IN LEARNING IF CLAUSES?
Authors: Tiarsiwi Fidaniar
Published: November 2021

Metacognitive strategies are expected as ‘higher order executive skills' which enable college students to approach learning systematically and effectively by using the elements of planning, monitoring and evaluating. This study is conducted to investigate whether or not metacognitive strategies can affect the development of structural knowledge of students. To reflect how the students use these strategies, learning diary can lead the learners to strategy use. Twenty-one participants of third semester students were involved. Nine of them were selected to be probed intensively for their metacognitive habits in learning If Clauses. Then, they were divided into three groups according to the level of students' progress and their mid test score. The first group was assumed as novice learners, the second group was categorized as medium level students and the last group was presumed as expert learners. This study revealed that expert learners were better diarist in documenting what they did when learning. The medium level students also indicated that their capability in realizing the use of their cognition was up and down. They were good at evaluating their shortcoming and monitoring some progress, but they were poor at planning and modifying strategies. Meanwhile, the novice learners less reflected how they learned on their documentation. It could be illustrated that they did not have any motivation to plan their learning, evaluate and monitor their learning.
Dextromethorphan-quinidine is helpful for pseudobulbar affect disorder in stroke patients
Authors: Francis Michael , Hamame Mira , Nasrallah Mariam , Nesbitt Alison , Meza James P.
Published: November 2021

An informed consent article using

Hammond FM, Alexander DN, Cutler AJ, et al. PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury. BMC Neurology. 2016;16:89. https://doi.org/10.1186/s12883-016-0609-0

for a patient with pseudobulbar affect following stroke.
Interseccionalidade em uma zona de sacrifício do capital: a experiência de mulheres negras, quilombolas e marisqueiras da Ilha de Maré, baía de Todos os Santos (Bahia, Brasil)
Authors: Rodin Patricia
Published: November 2021

Este artigo se baseia em uma pesquisa empírica cujo objetivo é analisar, a partir de uma perspectiva interseccional, como as mulheres negras, quilombolas e marisqueiras de duas comunidades da Ilha de Maré (Baía de Todos os Santos, Salvador, Bahia) são afetadas pela ocupação de seu território pela cadeia petrolífera. A compreensão da complexidade da experiência que essas mulheres vivenciam em seu território de vida, no atual contexto de conflito ambiental, só pode ser alcançada considerando a intersecção dos marcadores de raça, gênero, classe e o que aqui denominamos de modo de vida ligado ao meio ambiente.
MICROSTRUCTURE AND MARTENSITIC TRANSFORMATION OF Ni_{50}Ti_{50-x}Er_{x} SHAPE MEMORY ALLOYS
Authors: Dovchinvanchig M. , Gangantogos Ya. , Munkhjargal B.
Published: November 2021

The effect of rare earth element Er addition on the microstructure and phase transformation behavior of Ni_{50}Ti_{50-x}Er_{x} (x =0, 1, 5) shape memory alloy was investigated experimentally. The results showed that the microstructure of Ni-Ti-Er ternary alloys consists of the NiEr precipitate and the NiTi matrix. A one-step martensitic transformation was observed in all alloys. The martensitic transformation temperature M_s increased gradually with increasing Er content.
СҮЛЖЭЭГ ЗАДЛАХ БОДЛОГОД ЗОРИУЛСАН ДАХИН ОРУУЛАХ ТЕХНИКИЙГ САЙЖРУУЛАХ
Authors: Гантулга Г. , Далайжаргал П.
Published: November 2021

Сүлжээнээс хасахад сүлжээ өөрөө жижиг хэмжээстэй холбоост бүрдлүүд болгон задардаг байхаар хамгийн цөөн оройг олохыг Сүлжээг Задлах Бодлого (Network Dismantling Problem) гэнэ.Уг бодлого нь нийгэм, биологи, технологийн сүлжээнүүдийн бат бөх чанарыг судлахаас гадна, дутагдалтай бүтцийг судлахад ач холбогдолтой. Сүүлийн жилүүдэд дахин оруулах аргыг сүлжээг задлах бодлогод ашиглах судалгаа хийгдэж эхлээд байна. Гэхдээ дахин оруулах аргын судалгаа дутмаг байна. Энэхүү ажлаар бид нэгэн шинэ дахин оруулах аргыг танилцууллаа. Дэвшүүлсэн аргаа нийгэм, биологи, технологийн төрлийн 13-н сүлжээний өгөгдлийг ашиглан туршив. Туршилтын үр дүнгээс харахад дэвшүүлсэн арга ихэнх сүлжээний хувьд бусад аргаас давуу үр дүн үзүүллээ.
A Fatal Masquerade in Pneumonia: Ruptured Thoracic Aortic Aneurysm
Authors: Liu Ching-Han , Huang Shih-Chung , Hsu Ching-Tsai
Published: November 2021

we described an 87-year-old man who presented with fever and hemoptysis.
Nosocomial pneumonia was initially impressed. However, the patient has
worsening hemoptysis despite defervescence. Computed tomography of chest
disclosed ruptured thoracic aortic aneurysm. Emergent surgery was then
commenced for adequate treatment.
Prediction of rubber vulcanization using an artificial neural network
Authors: Lubura Jelena , Kojic Predrag , Pavlicevic Jelena , Ikonic Bojana , Omorjan Radovan , Bera Oskar
Published: November 2021

Determination of rubber rheological properties is indispensable in order to
conduct efficient vulcanization process in rubber industry. The main goal of
this study was development of an advanced artificial neural network (ANN)
for quick and accurate vulcanization data prediction of commercially
available rubber gum for tire production. The ANN was developed by using the
platform for large-scale machine learning TensorFlow with the Sequential
Keras-Dense layer model, in a Python framework. The ANN was trained and
validated on previously determined experimental data of torque on time at
five different temperatures, in the range from 140 to 180 oC, with a step of
10 oC. The activation functions, ReLU, Sigmoid and Softplus, were used to
minimize error, where the ANN model with Softplus showed the most accurate
predictions. Numbers of neurons and layers were varied, where the ANN with
two layers and 20 neurons in each layer showed the most valid results. The
proposed ANN was trained at temperatures of 140, 160 and 180 oC and used to
predict the torque dependence on time for two test temperatures (150 and 170
oC). The obtained solutions were confirmed as accurate predictions, showing
the mean absolute percentage error (MAPE) and mean squared error (MSE)
values were less than 1.99 % and 0.032 dN2 m2, respectively.
LGBT in Student Knowledge and Attitudes: Value Education Perspective
Authors: Indrawadi Junaidi , Moeis Isnarmi , Nurman Nurman , Luthfi Zaky Farid
Published: November 2021

Lesbian, Gay, Bisexual, and Transgender (LGBT) phenomena are one of the problems of the nation today. These problems become debatable among politicians, legal experts, and academicians. On the other hand, Pancasila Education is a personality development course that transforms the noble values of the nation has not been able to prevent the development of LGBT. Relating to the threats of LGBT, this study aims to develop an anti-LGBT values learning model that is integrated into the Pancasila Education. The initial stage of the study discusses the students’ knowledge and attitudes towards LGBT. A Likert scale questionnaire was employed to collect data; the sample of the study was chosen randomly from students taking the Pancasila Education course. The data were analyzed using SPSS version 20. The research findings indicated that students had sufficient knowledge about LGBT, and they had a firm attitude against LGBT. This finding suggests that most students still have a good practice of religious and traditional values to stay away from LGBT.
Parental Social Support and Achievement Motivation on Self-Regulated Learning Strategy with an Interest as a Mediator Variable
Authors: Saputra Dhanu , Daliman Daliman
Published: November 2021

Social cognitive theory explains how the individual's environment can influence the emergence of intrinsic motivation which can encourage students to be able to learn independently and be able to achieve learning goals. This study aims to analyze the effect of parental social support and achievement motivation with self-regulated learning with interest as a mediator variable. This research was conducted in 3 different schools. The number of the population in this study amounted to 730 students. While the number of samples used was 288 students. The sampling technique in this study used purposive sampling technique with the criteria for assessing favorite, ordinary and less favorite schools based on the assessment of the surrounding community. The data analysis technique used is the Structural Equation Modeling (SEM) model with the AMOS program. The results of this study indicate that there is a significant influence between social support and achievement motivation on interest. There is a significant influence between social support, achievement motivation and interest in self-regulated learning. There is an influence between social support and achievement motivation on self-regulated learning through interest variables. Students who have high motivation tend to apply high self-regulated learning so that students are encouraged to improve their performance, have the courage to take risks, are creative, and innovative. This can be used as a theoretical and empirical reference in developing student learning independence.
Application of Science Education Crossword Puzzle Multimedia to Improve the Outcomes and Learning Process at Junior High Schools in Digestive System
Authors: Marlina Reni , Oktavianty Erwina , Silitonga Haratua Tiur Maria , Sandra Novi Maulidia
Published: November 2021

This study aims to improve the teaching and learning process and outcomes, improve the implementation process of instruction, and improve student learning outcomes by combining cooperative learning models with natural science educational crossword puzzle multimedia on the digestive system instructional material. The form of research used is Lesson study, which is designed in 2 cycles, each cycle having 1 meeting. At each meeting, students learnt in groups using the natural science educational crossword puzzle multimedia. The results showed that the application of educational crossword puzzle multimedia was carried out well in each cycle (100%) with very strong criteria. Study results also described that the average activeness of students was 100% with very strong criteria. Based on the analysis of student achievement in the cycle I with an average score of 80.29, mastery of 82.61%, and in the second Cycle 83.48 with mastery of 91.30%, it can be concluded that thr application of natural science educational crossword puzzle multimedia supports the learning process for the better and improves student learning outcomes, especially in the material of digestive system.
Goal Orientation & Metacognitive Self-Regulation Students on Discourse Learning
Authors: Deasyanti Deasyanti , Yudhistira Santi
Published: November 2021

Corona Virus Disease 2019 (COVID-19) has impacted throughout all aspects of human life including education.  Despite the previously applied distance education or e-learning in the conventional education, nowadays this instructional model became a newly common approach in education. Therefore, students have to make some adjustments in their learning approach in order to reach out their learning goals. Self-regulated learning (SRL) is a process of monitoring and controlling learning behaviors to achieve learning goals. One of the key factors that contribute to SRL is achievement goal orientation. The aim of this study is to find out the role of types of goal orientation towards metacognitive self-regulation. A total of 320 undergraduate students participated in this study. The findings showed that performance approach and performance avoidance were the significant predictors of metacognitive self-regulation. Students’ preferences to performance goal-orientations were associated with the preliminary study findings that the new instructional model was related to decreased students’ efficacy in learning and feelings of uncertainty to their academic achievement.
Kedisiplinan Kerja dan Lingkungan Kerja Terhadap Kinerja Pegawai
Authors: Mauli Monica , Wijayanto Petrus
Published: November 2021

Banyak pegawai yang tidak memakai seragam sesuai dengan harinya, sehingga dapat diketahui bahwa masih terdapat kurangnya kedisiplinan yang diterapkan oleh pegawai. Selain itu, fasilitas yang masih kurang memadai menyebabkan kinerja pegawai menurun. Penelitian ini bertujuan untuk menganalisis pengaruh kedisiplinan kerja dan lingkungan kerja terhadap terhadap kinerja pegawai. Penelitian ini merupakan penelitian kuantitatif. Populasi dalam penelitian ini berjumlah 44 orang pegawai. Teknik pengambilan sampel menggunakan metode sampling jenuh. Teknik pengumpulan data dilakukan dengan kuesioner yang disebarkan langsung ke pegawai yangf terdiri dari 44 responden. Analisis statistic yang digunakan adalah Analisis Regresi Linear berganda. Penelitian ini menggunakan SPSS. Hasil penelitian ini menunjukkanbahwa disiplin kerja, lingkungan kerja memiliki pengaruh terhadap kinerja pegawai. Implikasi penelitian ini dapat memberikan dampak dalam meningkatkan kinerja pegawai.
Estimation of age of transition from children's to adult healthcare for young people with long term conditions using linked routinely collected healthcare data
Authors: Jarvis Stuart William , Richardson Gerry , Flemming Kate , Fraser Lorna
Published: November 2021

IntroductionHealthcare transitions, including from paediatric to adult services, can be disruptive and cause a lack of continuity in care. Existing research on the paediatric-adult healthcare transition often uses a simple age cut-off to assign transition status. This risks misclassification bias, reducing observed changes at transition (adults are included in the paediatric group and vice versa) possibly to differing extents between groups that transition at different ages.
ObjectiveTo develop and assess methods for estimating the transition point from paediatric to adult healthcare from routine healthcare records.
MethodsA retrospective cohort of young people (12 to 23 years) with long term conditions was constructed from linked primary and secondary care data in England. Inpatient and outpatient records were classified as paediatric or adult based on treatment and clinician specialities. Transition point was estimated using three methods based on record classification (First Adult: the date of first adult record; Last Paediatric: date of last paediatric record; Fitted: a date determined by statistical fitting). Estimated transition age was compared between methods. A simulation explored impacts of estimation approaches compared to a simple age cut-off when assessing associations between transition status and healthcare events.
ResultsSimulations showed using an age-based cut-off at 16 or 18 years as transition point, common in research on transition, may underestimate transition-associated changes. Many health records for those aged 14 years were classified as adult, limiting utility of the First Adult approach. The Last Paediatric approach is least sensitive to this possible misclassification and may best reflect experience of the transition.
ConclusionsEstimating transition point from routine healthcare data is possible and offers advantages over a simple age cut-off. These methods, adapted as necessary for data from other countries, should be used to reduce risk of misclassification bias in studies of transition in nationally representative data.
Mikä muuttui vai muuttuiko mikään? Yli 65-vuotiaiden arki korona-aikana
Authors: Ahosola Päivi , Tuominen Katariina , Tiainen Kristina , Jolanki Outi
Published: November 2021

Koronapandemian leviämisen estämiseksi asetetut rajoitukset ovat kohdistuneet erityisesti ikäihmisiin, joille tauti on vaarallisin. Miten korona-aika rajoituksineen on näkynyt ikääntyneiden elämässä ja hyvinvoinnissa? Tutkimuksemme aineistona on 31 kesällä 2020 tehtyä puhelinhaastattelua. Korona-aika rajoituksineen oli vaikuttanut haastateltujen arkeen ja hyvinvointiin eri tavoin. Suuri osa koki arkensa muuttuneen vain vähän tai ei ollenkaan, osa taas koki hyvinvointinsa huonontuneen merkittävästi. Jotkut kokivat arkensa jopa parantuneen. Niillä, joilla arki ei ollut juuri muuttunut, elämä oli saattanut olla jo ennestään rajoittunutta huonon toimintakyvyn ja vähäisten sosiaalisten kontaktien vuoksi. Osa haastatelluista oli kyennyt joko yksin tai muiden ihmisten tuella kehittämään uusia tapoja toimia, jolloin oli ollut mahdollista säilyttää arki lähes ennallaan. Ympäristön, kuten kävelyreittien ja viheralueiden, merkitys hyvinvoinnin ylläpitäjänä korostui pandemia-aikana. Yhteydenpito muihin ihmisiin puhelimitse oli tärkeä keino ylläpitää hyvinvointia. Uusi teknologia oli korvannut kasvokkaisia tapaamisia lähinnä niillä, joilla oli ennestään kokemusta sen käytöstä. Ikääntyneiden korona-arjessa korostuivat sopeutuminen, joustavuus ja elämänkokemuksen pohjalta syntyneet valmiudet pandemia-ajan kohtaamiseen.