bluuebunny/crossref_metadata_2025 huggingface dataset:
EL TRIAJE PARA MEJORAR LA CALIDAD DE ATENCIÓN SANITARIA EN UN HOSPITAL PÚBLICO DE URUGUAY
Authors: Castro Janette
Published: February 2024

Este artículo tuvo como objetivo general establecer un modelo de triage que asegure la adecuada recepción, acogida, clasificación y referencia de los usuarios que demandan asistencia en el servicio de urgencias de un hospital público de Uruguay. Desde lo metodológico, la investigación fue cuantitativa, de campo, descriptiva y de corte transversal. El universo fue el 100% (N= 3.655) de los pacientes que acudieron al servicio de urgencias del mencionado hospital. La muestra fue intencional y quedo conformada por (n= 1.828) pacientes y familiares que demandaron asistencia en el servicio de urgencias del hospital, entre los meses de julio y agosto del año 2017. La técnica de recolección de datos fue la encuesta y el instrumento un cuestionario, en escala dicotómica (Si-NO), con veinte (20) ítems para medir las dimensiones: 1)-Protocolo de atención en salud, 2)-Eficacia de la atención, 3)-Satisfacción del usuario y 4)-Satisfacción del servicio de triaje. La evaluación de la satisfacción del usuario se realizó en los meses de julio y agosto del 2017, aplicando una encuesta telefónica a los pacientes o familiares por un administrativo del hospital. Se establecieron grupos de expertos para la creación del protocolo, una enfermera se encargaba de hacer el ingreso a la historia clínica electrónica en base a algoritmos predefinidos, lo que permitió la categorización, separando las emergencias de las urgencias y las no urgencias. Entre las conclusiones se destaca que en los servicios de emergencias de una institución de salud, el triaje es un instrumento de ayuda a la gestión de la asistencia del servicio, colaborando en su eficiencia y aportando un orden ético basado en la urgencia/gravedad de los pacientes, para aumentar la satisfacción de los usuarios y de los profesionales de la salud al racionalizar los recursos en la mejora de la calidad global del servicio.
Claves para la construcción de un modelo bioético para la atención humanizada de los servicios de salud a partir del modelo colombiano
Authors: Blandin Abalos Julia Beatriz
Published: February 2024

Este articulo pretende reflexionar sobre el trabajo realizado por Carlos Andrés Andino Acosta denominado ̈La humanización, un asunto ético en la acreditación en salud ̈. El objetivo principal, es compararlo con la mirada de la escritora, acerca del sistema de salud en Uruguay en la actualidad. El diseño y método de este estudio es comparativo con el fin de obtener las similitudes y diferencias entre el modelo colombiano y el uruguayo. El trabajo de Andino se ha enfocado en el esclarecimiento de los problemas de la humanidad, lo cual forma parte también del proceso de certificación en salud que buscan las organizaciones hospitalarias. Por otra parte, en Uruguay, desde la conformación del Sistema Nacional Integrado de Salud (SNIS) el concepto de humanización dice presente, mostrando la gran importancia de la integración de la humanización de la salud en todos los procesos administrativos y asistenciales. Como resultado, es necesario para la construcción de un modelo bioético en salud, conocer y con- templar las necesidades de los individuos. Para concluir resulta fundamental trabajar no solo en los sistemas de cuidado, sino en extender a la cultura nacional, pruebas del respeto a la vida y la defensa de su dignidad. La humanización reclama desde sus referentes éticos, morales y bioéticos una nueva interpretación y comprensión interdisciplinar, y en la medida de las posibilidades, debe estructurarse desde estas fuentes y definiciones también como un proceso de planeación, de gestión, y hacer parte de las líneas trasversales, estratégicas y administrativas de las instituciones prestadoras de servicios de salud.
A new look at the architecture and dynamics of the Hydra nerve net
Authors: Keramidioti Athina , Schneid Sandra , Busse Christina , Cramer von Laue Christoph , Bertulat Bianca , Salvenmoser Willi , Hess Martin , Alexandrova Olga , Glauber Kristine M , Steele Robert E , Hobmayer Bert , Holstein Thomas W , David Charles N
Published: February 2024

The Hydra nervous system is the paradigm of a ‘simple nerve net’. Nerve cells in Hydra, as in many cnidarian polyps, are organized in a nerve net extending throughout the body column. This nerve net is required for control of spontaneous behavior: elimination of nerve cells leads to polyps that do not move and are incapable of capturing and ingesting prey (Campbell, 1976). We have re-examined the structure of the Hydra nerve net by immunostaining fixed polyps with a novel antibody that stains all nerve cells in Hydra. Confocal imaging shows that there are two distinct nerve nets, one in the ectoderm and one in the endoderm, with the unexpected absence of nerve cells in the endoderm of the tentacles. The nerve nets in the ectoderm and endoderm do not contact each other. High-resolution TEM (transmission electron microscopy) and serial block face SEM (scanning electron microscopy) show that the nerve nets consist of bundles of parallel overlapping neurites. Results from transgenic lines show that neurite bundles include different neural circuits and hence that neurites in bundles require circuit-specific recognition. Nerve cell-specific innexins indicate that gap junctions can provide this specificity. The occurrence of bundles of neurites supports a model for continuous growth and differentiation of the nerve net by lateral addition of new nerve cells to the existing net. This model was confirmed by tracking newly differentiated nerve cells.
Molecular classification and tumor microenvironment characteristics in pheochromocytomas
Authors: Qin Sen , Xu Yawei , Yu Shimiao , Han Wencong , Fan Shiheng , Ai Wenxiang , Zhang Kenan , Wang Yizhou , Zhou Xuehong , Shen Qi , Gong Kan , Sun Luyang , Zhang Zheng
Published: February 2024

Pheochromocytomas (PCCs) are rare neuroendocrine tumors that originate from chromaffin cells in the adrenal gland. However, the cellular molecular characteristics and immune microenvironment of PCCs are incompletely understood. Here, we performed single-cell RNA sequencing (scRNA-seq) on 16 tissues from 4 sporadic unclassified PCC patients and 1 hereditary PCC patient with Von Hippel-Lindau (VHL) syndrome. We found that intra-tumoral heterogeneity was less extensive than the inter-individual heterogeneity of PCCs. Further, the unclassified PCC patients were divided into two types, metabolism-type (marked by NDUFA4L2 and COX4I2) and kinase-type (marked by RET and PNMT), validated by immunohistochemical staining. Trajectory analysis of tumor evolution revealed that metabolism-type PCC cells display phenotype of consistently active metabolism and increased metastasis potential, while kinase-type PCC cells showed decreased epinephrine synthesis and neuron-like phenotypes. Cell-cell communication analysis showed activation of the annexin pathway and a strong inflammation reaction in metabolism-type PCCs and activation of FGF signaling in the kinase-type PCC. Although multispectral immunofluorescence staining showed a lack of CD8+ T cell infiltration in both metabolism-type and kinase-type PCCs, only the kinase-type PCC exhibited downregulation of HLA-I molecules that possibly regulated by RET, suggesting the potential of combined therapy with kinase inhibitors and immunotherapy for kinase-type PCCs; in contrast, the application of immunotherapy to metabolism-type PCCs (with antigen presentation ability) is likely unsuitable. Our study presents a single-cell transcriptomics-based molecular classification and microenvironment characterization of PCCs, providing clues for potential therapeutic strategies to treat PCCs.
RBP-J regulates homeostasis and function of circulating Ly6Clo monocytes
Authors: Kou Tiantian , Kang Lan , Zhang Bin , Li Jiaqi , Zhao Baohong , Zeng Wenwen , Hu Xiaoyu
Published: February 2024

Notch-RBP-J signaling plays an essential role in the maintenance of myeloid homeostasis. However, its role in monocyte cell fate decisions is not fully understood. Here, we showed that conditional deletion of transcription factor RBP-J in myeloid cells resulted in marked accumulation of blood Ly6Clo monocytes that highly expressed chemokine receptor CCR2. Bone marrow transplantation and parabiosis experiments revealed a cell-intrinsic requirement of RBP-J for controlling blood Ly6CloCCR2hi monocytes. RBP-J-deficient Ly6Clo monocytes exhibited enhanced capacity competing with wildtype counterparts in blood circulation. In accordance with alterations of circulating monocytes, RBP-J deficiency led to markedly increased population of lung tissues with Ly6Clo monocytes and CD16.2+ interstitial macrophages. Furthermore, RBP-J deficiency-associated phenotypes could be genetically corrected by further deleting Ccr2 in myeloid cells. These results demonstrate that RBP-J functions as a crucial regulator of blood Ly6Clo monocytes and thus derived lung-resident myeloid populations, at least in part through regulation of CCR2.
Speech-induced suppression and vocal feedback sensitivity in human cortex
Authors: Ozker Muge , Yu Leyao , Dugan Patricia , Doyle Werner , Friedman Daniel , Devinsky Orrin , Flinker Adeen
Published: February 2024

Across the animal kingdom, neural responses in the auditory cortex are suppressed during vocalization, and humans are no exception. A common hypothesis is that suppression increases sensitivity to auditory feedback, enabling the detection of vocalization errors. This hypothesis has been previously confirmed in non-human primates, however a direct link between auditory suppression and sensitivity in human speech monitoring remains elusive. To address this issue, we obtained intracranial electroencephalography (iEEG) recordings from 35 neurosurgical participants during speech production. We first characterized the detailed topography of auditory suppression, which varied across superior temporal gyrus (STG). Next, we performed a delayed auditory feedback (DAF) task to determine whether the suppressed sites were also sensitive to auditory feedback alterations. Indeed, overlapping sites showed enhanced responses to feedback, indicating sensitivity. Importantly, there was a strong correlation between the degree of auditory suppression and feedback sensitivity, suggesting suppression might be a key mechanism that underlies speech monitoring. Further, we found that when participants produced speech with simultaneous auditory feedback, posterior STG was selectively activated if participants were engaged in a DAF paradigm, suggesting that increased attentional load can modulate auditory feedback sensitivity.
Distinct catecholaminergic pathways projecting to hippocampal CA1 transmit contrasting signals during navigation in familiar and novel environments
Authors: Heer Chad , Sheffield Mark
Published: February 2024

Neuromodulatory inputs to the hippocampus play pivotal roles in modulating synaptic plasticity, shaping neuronal activity, and influencing learning and memory. Recently, it has been shown that the main sources of catecholamines to the hippocampus, ventral tegmental area (VTA) and locus coeruleus (LC), may have overlapping release of neurotransmitters and effects on the hippocampus. Therefore, to dissect the impacts of both VTA and LC circuits on hippocampal function, a thorough examination of how these pathways might differentially operate during behavior and learning is necessary. We therefore utilized two-photon microscopy to functionally image the activity of VTA and LC axons within the CA1 region of the dorsal hippocampus in head-fixed male mice navigating linear paths within virtual reality (VR) environments. We found that within familiar environments some VTA axons and the vast majority of LC axons showed a correlation with the animals’ running speed. However, as mice approached previously learned rewarded locations, a large majority of VTA axons exhibited a gradual ramping-up of activity, peaking at the reward location. In contrast, LC axons displayed a pre-movement signal predictive of the animal’s transition from immobility to movement. Interestingly, a marked divergence emerged following a switch from the familiar to novel VR environments. Many LC axons showed large increases in activity that remained elevated for over a minute, while the previously observed VTA axon ramping-to-reward dynamics disappeared during the same period. In conclusion, these findings highlight distinct roles of VTA and LC catecholaminergic inputs in the dorsal CA1 hippocampal region. These inputs encode unique information, with reward information in VTA inputs and novelty and kinematic information in LC inputs, likely contributing to differential modulation of hippocampal activity during behavior and learning.
An approach to the dermatological classification of histopathological skin images using a hybridized CNN-DenseNet model
Authors: De Anubhav , Mishra Nilamadhab , Chang Hsien-Tsung
Published: February 2024

This research addresses the challenge of automating skin disease diagnosis using dermatoscopic images. The primary issue lies in accurately classifying pigmented skin lesions, which traditionally rely on manual assessment by dermatologists and are prone to subjectivity and time consumption. By integrating a hybrid CNN-DenseNet model, this study aimed to overcome the complexities of differentiating various skin diseases and automating the diagnostic process effectively. Our methodology involved rigorous data preprocessing, exploratory data analysis, normalization, and label encoding. Techniques such as model hybridization, batch normalization and data fitting were employed to optimize the model architecture and data fitting. Initial iterations of our convolutional neural network (CNN) model achieved an accuracy of 76.22% on the test data and 75.69% on the validation data. Recognizing the need for improvement, the model was hybridized with DenseNet architecture and ResNet architecture was implemented for feature extraction and then further trained on the HAM10000 and PAD-UFES-20 datasets. Overall, our efforts resulted in a hybrid model that demonstrated an impressive accuracy of 95.7% on the HAM10000 dataset and 91.07% on the PAD-UFES-20 dataset. In comparison to recently published works, our model stands out because of its potential to effectively diagnose skin diseases such as melanocytic nevi, melanoma, benign keratosis-like lesions, basal cell carcinoma, actinic keratoses, vascular lesions, and dermatofibroma, all of which rival the diagnostic accuracy of real-world clinical specialists but also offer customization potential for more nuanced clinical uses.
Conservation gaps and priorities of range-restricted birds in the Northern Andes
Authors: Medina Wilderson , Pimm Stuart L. , Huang Ryan M.
Published: February 2024

The ongoing destruction of habitats in the tropics accelerates the current rate of species extinction. Range-restricted species are exceptionally vulnerable, yet we have insufficient knowledge about their protection. Species’ current distributions, range sizes, and protection gaps are crucial to determining conservation priorities. Here, we identified priority range-restricted bird species and their conservation hotspots in the Northern Andes. We employed maps of the Area of Habitat (AOH), that better reflect their current distributions than existing maps. AOH provides unprecedented resolution and maps a species in the detail essential for practical conservation actions. We estimated protection within each species’ AOH and for the cumulative distribution of all 335 forest-dependent range-restricted birds across the Northern Andes. For the latter, we also calculated protection across the elevational gradient. We estimated how much additional protection community lands (Indigenous and Afro-Latin American lands) would contribute if they were conservation-focused. AOHs ranged from 8 to 141,000 km2. We identified four conservation priorities based on cumulative species richness: the number of AOHs stacked per unit area. These priorities are high-resolution mapped representations of Endemic Bird Areas for the Tropical Andes that we consider critically important. Protected areas cover only 31% of the cumulative AOH, but community lands could add 19% more protection. Sixty-two per cent of the 335 species have ranges smaller than their published estimates, yet IUCN designates only 23% of these as Threatened. We identified 50 species as top conservation priorities. Most of these concentrate in areas of low protection near community lands and at middle elevations where, on average, only 34% of the land is protected. We highlight the importance of collaborative efforts among stakeholders: governments should support private and community-based conservation practices to protect the region with the most range-restricted birds worldwide.
Mathematical modelling of antibiotic interaction on evolution of antibiotic resistance: an analytical approach
Authors: Nashebi Ramin , Sari Murat , Kotil Seyfullah Enes
Published: February 2024

Background

The emergence and spread of antibiotic-resistant pathogens have led to the exploration of antibiotic combinations to enhance clinical effectiveness and counter resistance development. Synergistic and antagonistic interactions between antibiotics can intensify or diminish the combined therapy’s impact. Moreover, these interactions can evolve as bacteria transition from wildtype to mutant (resistant) strains. Experimental studies have shown that the antagonistically interacting antibiotics against wildtype bacteria slow down the evolution of resistance. Interestingly, other studies have shown that antibiotics that interact antagonistically against mutants accelerate resistance. However, it is unclear if the beneficial effect of antagonism in the wildtype bacteria is more critical than the detrimental effect of antagonism in the mutants. This study aims to illuminate the importance of antibiotic interactions against wildtype bacteria and mutants on the deacceleration of antimicrobial resistance.

Methods

To address this, we developed and analyzed a mathematical model that explores the population dynamics of wildtype and mutant bacteria under the influence of interacting antibiotics. The model investigates the relationship between synergistic and antagonistic antibiotic interactions with respect to the growth rate of mutant bacteria acquiring resistance. Stability analysis was conducted for equilibrium points representing bacteria-free conditions, all-mutant scenarios, and coexistence of both types. Numerical simulations corroborated the analytical findings, illustrating the temporal dynamics of wildtype and mutant bacteria under different combination therapies.

Results

Our analysis provides analytical clarification and numerical validation that antibiotic interactions against wildtype bacteria exert a more significant effect on reducing the rate of resistance development than interactions against mutants. Specifically, our findings highlight the crucial role of antagonistic antibiotic interactions against wildtype bacteria in slowing the growth rate of resistant mutants. In contrast, antagonistic interactions against mutants only marginally affect resistance evolution and may even accelerate it.

Conclusion

Our results emphasize the importance of considering the nature of antibiotic interactions against wildtype bacteria rather than mutants when aiming to slow down the acquisition of antibiotic resistance.
Genome-wide association studies reveal stable loci for wheat grain size under different sowing dates
Authors: Hong Yi , Zhang Mengna , Yuan Zechen , Zhu Juan , Lv Chao , Guo Baojian , Wang Feifei , Xu Rugen
Published: February 2024

Background

Wheat (Tritium aestivum L.) production is critical for global food security. In recent years, due to climate change and the prolonged growing period of rice varieties, the delayed sowing of wheat has resulted in a loss of grain yield in the area of the middle and lower reaches of the Yangtze River. It is of great significance to screen for natural germplasm resources of wheat that are resistant to late sowing and to explore genetic loci that stably control grain size and yield.

Methods

A collection of 327 wheat accessions from diverse sources were subjected to genome-wide association studies using genotyping-by-sequencing. Field trials were conducted under normal, delayed, and seriously delayed sowing conditions for grain length, width, and thousand-grain weight at two sites. Additionally, the additive main effects and multiplicative interaction (AMMI) model was applied to evaluate the stability of thousand-grain weight of 327 accessions across multiple sowing dates.

Results

Four wheat germplasm resources have been screened, demonstrating higher stability of thousand-grain weight. A total of 43, 35, and 39 significant MTAs were determined across all chromosomes except for 4D under the three sowing dates, respectively. A total of 10.31% of MTAs that stably affect wheat grain size could be repeatedly identified in at least two sowing dates, with PVE ranging from 0.03% to 38.06%. Among these, six were for GL, three for GW, and one for TGW. There were three novel and stable loci (4A_598189950, 4B_307707920, 2D_622241054) located in conserved regions of the genome, which provide excellent genetic resources for pyramid breeding strategies of superior loci. Our findings offer a theoretical basis for cultivar improvement and marker-assisted selection in wheat breeding practices.
An alternative peptone preparation using Hermetia illucens (Black soldier fly) hydrolysis: process optimization and performance evaluation
Authors: Liu Gaoqiang , Tiang Ming Foong , Ma Shixia , Wei Zeyan , Liang Xiaolin , Sajab Mohd Shaiful , Abdul Peer Mohamed , Zhou Xueyan , Ma Zhongren , Ding Gongtao
Published: February 2024

Background

Hermetia illucens (HI), commonly known as the black soldier fly, has been recognized for its prowess in resource utilization and environmental protection because of its ability to transform organic waste into animal feed for livestock, poultry, and aquaculture. However, the potential of the black soldier fly’s high protein content for more than cheap feedstock is still largely unexplored.

Methods

This study innovatively explores the potential of H. illucens larvae (HIL) protein as a peptone substitute for microbial culture media. Four commercial proteases (alkaline protease, trypsin, trypsase, and papain) were explored to hydrolyze the defatted HIL, and the experimental conditions were optimized via response surface methodology experimental design. The hydrolysate of the defatted HIL was subsequently vacuum freeze-dried and deployed as a growth medium for three bacterial strains (Staphylococcus aureus, Bacillus subtilis, and Escherichia coli) to determine the growth kinetics between the HIL peptone and commercial peptone.

Results

The optimal conditions were 1.70% w/w complex enzyme (alkaline protease: trypsin at 1:1 ratio) at pH 7.0 and 54 °C for a duration of 4 h. Under these conditions, the hydrolysis of defatted HIL yielded 19.25% ±0.49%. A growth kinetic analysis showed no significant difference in growth parameters (μmax, Xmax, and λ) between the HIL peptone and commercial peptone, demonstrating that the HIL hydrolysate could serve as an effective, low-cost alternative to commercial peptone. This study introduces an innovative approach to HIL protein resource utilization, broadening its application beyond its current use in animal feed.
New records of immature aquatic Diptera from the Foulden Maar Fossil-Lagerstätte, New Zealand, and their biogeographic implications
Authors: Baranov Viktor O. , Haug Joachim T. , Kaulfuss Uwe
Published: February 2024

Background

The biogeographical and ecological history of true flies (Diptera) in New Zealand is little known due to a scarcity of fossil specimens. Here, we report a fauna of immature aquatic dipterans from freshwater diatomites of the early Miocene Foulden Maar Fossil-Lagerstätte in southern New Zealand.

Methods

We document 30 specimens of immature dipterans, mostly pupae, and compare their external morphology to extant aquatic Diptera. Based on the reconstructed paleoenvironment of Foulden Maar, we discuss taxonomic, ecological and taphonomic implications of this early Miocene fauna.

Results

Among Chironomidae, one pupal morphotype is attributed to Tanypodinae, one pupal morphotype and one larval morphotype are placed into Chironomus (Chironominae) and a further morphotype into Chironominae incertae sedis. Chaoboridae are represented by a pupal morphotype congeneric or very close to the extant Chaoborus, today globally distributed except for New Zealand. Additional immature specimens are likely larvae and puparia of brachyceran flies but cannot be identified to a narrower range. These finds document an aquatic dipteran fauna in New Zealand in the earliest Miocene and highlight Neogene extinction as a factor in shaping the extant Diptera fauna in New Zealand. Immature aquatic dipterans were a common and likely ecologically important component of the early Miocene Foulden Maar lake. Preservation of larvae and pupae may have been promoted by diatomaceous microbial mats and the light colour of the diatomite likely facilitated spotting of these minute fossils in the field.
Preliminary Study of Organic Farming Practices in Southern Rajasthan, India
Authors: Singh Hari , Sharma S. K. , Meena M. K.
Published: February 2024

In the present age of global warming and changing climatic scenario, agriculture has to be more eco- friendly with resource-conserving technologies for achieving the sustainable food-livelihood-environmental security. With growing awareness on food safety and health issue, demand for organically produced products increased drastically. To understand the economics and status of Organic Farming practices, a case study was conducted in Southern Rajasthan in the year 2020-21. A convenient sample of 317 organic cultivators were selected through multistage simple random sampling technique and data were collected through a pretested questionnaire along with semi structured interviews. Preliminary study shows that the net returns per hectare received from organic farming were relatively higher or good enough as compare to conventional counterparts. An increasing trend of growing organic products were observed during the study period. The major constraints identified by the organic cultivators were non-availability of labour and organic certification followed by the high wage rate and insect pest attacks. Sustainable efforts from government organizations, research institutes, marketing cells, progressive cultivators, dealers, and policy makers are necessary for successful adoption of the organic farming.
Gender Livelihood Strategies among Farmers’ Household in Kano State, Nigeria
Authors: Idris Amina Aminu , Abdullahi Ali
Published: February 2024

Gender-based livelihood continues to be one of the most prevalent issues facing Nigerian households, with implications in virtually every industry. This study accessed the gender-based livelihood strategies of farmers’ households in Kano State, Nigeria. The research was conducted in Kano state, four Local Government Areas (LGAs) in Kano State were selected using a multi-stage sampling procedure, and 215 farmers were randomly selected from 717 households in the LGAs. In addition, 80 households, of which 20 were randomly selected from each LGA, were interviewed about their means of subsistence. A combination of quantitative and qualitative techniques was used to gather information for the study. Both descriptive statistics and the Harvard Analytical Framework were used to analyse the collected data. The results revealed that the average age of farmers in Kano State was 35 years, the majority (89.3%) were married, with an average household size of 9 people, and 55.8% had informal education. The majority of productive activities were carried out by men and boys; both men and women carried out activities that generated income; and more than 70 percent of reproductive activities were carried out by women, as revealed by the household's livelihood strategies. It further revealed that women had limited access to resources and that the majority of resources were under the control of males in the study area. Men dominated access to and control over the resources that were available. It is recommended that women be encouraged to devise legal means for accessing and controlling resources in order to improve their livelihood status.
The Effect of Liquidity and Capital Intensity on Tax Aggressiveness
Authors: Astrina Fenty , Sunardi  , Pertiwi Anggun Putri
Published: February 2024

Aims: This research aims to determine and analyze the effect of liquidity and capital intensity on tax aggressiveness.

Study Design: The population in this study are Basic Industry and Chemical sub-sector manufacturing companies listed on the Indonesia Stock Exchange in the 2020-2022 period, namely 66 companies. The sampling method was purposive sampling. The final sample in this research was 22 companies and the total final sample was 66 samples. The data used is secondary data taken from the financial statements obtained from the Indonesian Stock Exchange.

Methodology: The data collection method is document analysis. The data analysis method used is quantitative analysis. The analysis techniques in this research are the classical assumption test, determinant coefficient test and Multiple Linear Regression.

Results: The results of this research show that liquidity influences tax aggressiveness, capital intensity influences tax aggressiveness.

Conclusion: The research results show that liquidity, capital intensity simultaneously affect tax aggressiveness. liquidity has a positive and significant effect on tax aggressiveness. Meaning that Companies with high liquidity are healthy companies with large tax liabilities so they have a higher potential for aggressive tax action. so does Capital Intensity has a positive and significant effect on Tax Aggressiveness. Meaning that higher fixed asset investment is carried out as a form of reducing profits and increasing depreciation expenses, thereby reducing the tax burden
Neonatal Hyperbilirubinemia: Causes, Symptoms, and Management in the Context of Research on Newborns
Authors: Dashdamirova Gulnara , Aliyeva Saadat
Published: February 2024

Hyperbilirubinemia is a medical disorder characterized by elevated blood levels of bilirubin, which can cause jaundice, or a yellowing of the skin, sclera, and nails. A condition known as hyperbilirubinemia frequently affects babies. Neonatal hyperbilirubinemia patients are managed with exchange transfusion and phototherapy. This study aimed to determine the neonatal hyperbilirubinemia therapies at the one private hospital in Azerbaijan. In 2023, data on the condition of hyperbilirubinemia and the kind of therapies received were gathered from medical records. Samples for this study were chosen based on inclusion criteria. Phototherapy was used to treat all 41 neonates with hyperbilirubinemia; 29.26 % of the patients received treatment for less than 24 hours, and 70.73 % received treatment for longer than 24 hours. 100% of patients recovered after treatment. After treatment, 100% patients cured. Hyperbilirubinemia neonates in this hospital were treated with phototherapy and the treatment was successful.
Exploring Thermal Dynamics of Gulabjamun Balls under Hypobaric Conditions
Authors: Sharanabasava  , Menon Rekha R.  , Nagaratna  , Praveen Kumar Y. S.  , Kumar G. Mahesh , Manjunatha M. , Shivanand
Published: February 2024

The physico-thermal characteristics of Gulabjamun, a traditional dairy product from the Indian subcontinent, were analyzed during hypobaric frying at different temperatures. The study involved frying Gulabjamun balls at 110°C, 115°C, and 120°C for 300 seconds. The sphericity of Gulabjamun was measured by assessing its dimensions along three major axes, resulting in values ranging from 0.969 ± 0.002 to 0.989 ± 0.002. After 300 seconds of frying, the expansion ratio of Gulabjamun ranged from 1.338 ± 0.10 to 1.410 ± 0.06. The apparent density of Gulabjamun decreased as the frying temperature increased. The thermal conductivity of Gulabjamun decreased with longer frying time and higher frying temperature. The thermal diffusivity initially increased up to 150 seconds and then decreased. The volumetric specific heat decreased with higher frying temperature. These findings enrich our comprehension of the intricate physical and thermal processes occurring during the low-pressure frying of Gulabjamun, providing significant implications for both research endeavors and practical applications in the industry.
A Comprehensive Analysis of Technology in Aeroponics: Presenting the Adoption and Integration of Technology in Sustainable Agriculture Practices
Authors: Kumar Ashwini , Trivedi Ayushi , Nandeha Nirjharnee , Patidar Girish , Choudhary Rishika , Singh Debesh
Published: February 2024

Aeroponics is a soilless farming method in which plants are grown by sprinkling a nutrient-rich fluid over their roots. Aeroponics has changed as a result of technology, which now offers advantages including automated nutrient supply, environmental management, and plant health monitoring. A key area of concern in light of the rising global food demand, climate change, and environmental issues is sustainable agriculture. This article highlights the integration of technology, sustainability, and socio-economic elements in modern agriculture by methodically examining the development of aeroponics practices from conventional ways to innovative modern techniques. When agronomic practices are viewed historically, they show a shift from labor-intensive, antiquated techniques to precision-based, technology-driven processes. Even though they were sustainable, traditional methods frequently had efficiency and scalability issues. A big change came with the arrival of the Green Revolution, which brought synthetic inputs and high-yield crop varieties. However, a reevaluation towards more sustainable practices was spurred by the approaches' long-term ecological implications. Precision agriculture, which makes use of sensor-based monitoring systems, artificial intelligence (AI), satellite and drone technologies, is a major feature of modern agronomy breakthroughs. According to the systematic research, Industry 4.0 and sensor technology are the most often used technologies in aeroponics. Numerous advantages, including time efficiency and sustainability, have come from these technologies. On the other hand, the research focused on power dependence and technical complexity as the primary obstacles in technology-assisted aeroponics.
Bio-prospecting the Efficacy of Carrier Based Inoculant of Rhizobium Strains as Plant Growth Promoter for the Development of Albizia procera Seedling
Authors: Ghabru Arti , Rana Neerja , Meenakshi  , Verma Geeta
Published: February 2024

The carrier-based formulation of rhizobial cultures in general, excels to register their effects on various plant growth parameters of Albizia procera seedlings. Carrier based bio-inoculant prepared with rhizobial isolate FA6 of Uttrakhand performed better for all plant growth characteristics. Charcoal based application of rhizobial isolates also increased the N, P, K content of soil. In case of seedlings treated with charcoal-based formulation of rhizobial isolate from Himachal Pradesh maximum available N (323.30 kg/ha), P (38.97 kg/ha) and K (395.9 kg/ha) content was recorded in T2 (Charcoal based formulation of BA2 strain+20kg/ha N) which was significantly superior to T3 and uninoculated control. Among the charcoal-based formulation of rhizobial isolate from Uttrakhand seedlings under treatment T2 (Charcoal based formulation of FA6 strain+20kg/ha N) registered maximum available N (327.7kg/ha), P (39.01 kg/ha) and K (397.4 kg/ha) content in soil.  Charcoal based application of rhizobial isolates significantly influenced the activity of soil enzymes (Dehydrogenase and Phosphatase). Application of Carrier based formulation of rhizobial isolate BA2 from Himachal Pradesh showed maximum dehydrogenase (11.20 μg TPF g-1h-1) and phosphatase (536.2 μmolL-1g-1h-1) activity as compare to uninoculated control. Whereas, among the rhizobial isolates from Uttrakhand maximum dehydrogenase (11.39 μg TPFg-1h-1) and phosphatase (545.4 μmol L-1g-1h-1) activity was also recorded with T2 (charcoal-based formulation of strain FA6+20kg/ha N) which was significantly superior to T3 and uninoculated control.
Influence of Various Bacterial and Fungal Strains on Fruit Cuttings: A Review
Authors: Singh Gurjeet , Thakur Ritik , Saha Naveen, Pankaj , Saini Vishakha , Sharma Sakshi , Singh Jatinder
Published: February 2024

Microbes, especially bacteria and fungi, play a significant role in the plant's multiplication outcome as well as in regulating the success of economic yield. There are some beneficial interactions made by the various fungi and bacteria, such as Pseudomonas aeruginosa, Bacillus subtilis, and endophytic fungi, which may be responsible for plant vigor, growth, shoot and root development. Bacterial and fungal strains engaged in the uptake, utilization and nutrient transportation in the earth's pores influence the distribution of essential vitamins and minerals for plant development. We may conclude that the influence of various bacterial and fungal strains on fruit cuttings is a complex and multifaceted issue. It is clear that advanced research is obligatory to better understand the precise interactions between different strains and fruit cuttings, as well as to develop strategies for managing and justifying the potential negative impacts. By achieving a deeper and clear understanding of these interactions, we can work towards optimizing health and productivity.
Synthesis of Silver Nanomaterials Capping by Fruit-mediated Extracts and Antimicrobial Activity: A Critical Review
Authors: Ahamed Md. Sazu , Ali Md. Shawan , Ahmed Shanawaz , Sadia Sumaiya Islam , Islam Md. Rockibul , Rahaman Md. Ashikur , Alam Md. Ashraful
Published: February 2024

Natural silver nanoparticles are currently being used innovatively by a unique simple route. Different bio-mediated fruit peel extracts were used to produce silver nanoparticles (AgNPs) and explore the synthesis of environmentally friendly aspects. To produce biodegradable AgNPs various bio-mediated fruit peel extracts function as reducing and capping agents in the synthesis route. It was discovered that several fruit peel extracts act as a capping agent and silver ions (Ag+ to Ag0). Due to reduction, the reaction changes the hydrogel's distinctive hue to a reddish-brown appearance. UV-visible spectra of the AgNPs showed a distinctive surface plasmon resonance (SPR) peak around 460.0 nm. Using X-ray diffraction, the crystallographic nature was discovered with brags diffraction. FT-IR confirmed silver ions function as a capping and reducing agent from peel extract. The transmission electron microscope confirmed that the average size of the nanoparticles was below 100.0 nm and internal morphology. These nanoparticles' ability to combat bacteria, algae and fungi was also well investigated. This manuscript highlights the different bio-mediated and peal extracts that are efficient in producing AgNPs and their function for promising antimicrobial activity.
The Influence of AI: The Revolutionary Effects of Artificial Intelligence in Healthcare Sector
Authors: Saxena Ashish K. , Ness Stephanie , Khinvasara Tushar
Published: February 2024

The application of artificial intelligence (AI) in healthcare is growing as it becomes more prevalent in modern business and everyday life. It is frequently regarded as a significant technological advancement in the present period. In recent times, the fields of artificial intelligence (AI) and big data analytics have been utilised in the domain of mobile health (m-health) to establish a highly efficient healthcare system. Modern medical research utilises diverse and poorly understood data, including electronic health records (EHRs), medical imaging, and complex language that is widely unorganised. The growth of mobile applications, together with healthcare systems, is a significant factor leading to the presence of disorganised and unstructured datasets. The enhanced accessibility of diverse datasets and advanced computer techniques like machine learning can enable researchers to usher in a new era of highly efficient genetic therapy. This review paper has clarified the role of machine learning algorithms in healthcare systems.
An Artificial Neural Network Model for Predicting Initial Water Saturation of Petroleum Reservoirs
Authors: Chikwe Anthony Ogbaegbe , Nwanwe Onyebuchi Ivan , Odo Jude Emeka , Patrick Aliene Chibuike , Onyejekwe Ifeanyichukwu Michael , Okalla Christian Emelu
Published: February 2024

Initial Water saturation is the water saturation of a reservoir before production commences. It enables the reservoir engineer to properly estimate the correct volume of Oil or gas reserves and to produce without water. And over the years over estimation or under estimation had caused major changes in the decision making of oil companies. New techniques are developed as technology advances to measure water saturation. These are the most widely used techniques for determining water saturation, nevertheless. Measurements obtained directly from a sealed core, which are more expensive, or calculations made using the Archie equation on sample well logs, which are less expensive. In this Project, Artificial Neural Network (ANN) model is the sole purpose of the modelling. The datasets are gathered, processed, trained, tested and validated.
Evaluation of Kokum [Garcinia indica (Thouars) Choisy] Genotypes for Growth, Yield and Quality Parameters under the Humid Tropical Conditions of Central Kerala
Authors: Tondihal Manjunath Sharanappa , Gowda Vikram H. Chinnappa , Chaitra. K  , Tippannavar Ajit
Published: February 2024

A study was conducted at the Department of Fruit Science, College of Agriculture, Vellanikkara, Kerala Agricultural University, Thrissur, to assess morphological, yield, and biochemical parameters of 29 kokum genotypes. Observations regarding growth, yield, and quality parameters were recorded for all the genotypes. The results showed that genotype IC136687-1 exhibited the highest height (15.60 m), while genotype IC552513 had the lowest height (5.20 m). The highest plant girth was observed in ACC.FSC-1 (156.88 cm), whereas the lowest girth was recorded in IC552522 (25.10 cm). The canopy spread of trees varied from 3.20 m (IC552513) to 8.10 m (ACC.FSC-4) in the East to West direction, and from 3.30 m (IC552513) to 9.42 m (ACC.FSC-9) in the North to South direction. The maximum canopy volume was found in ACC.FSC-9 (1030.01 m3), whereas the minimum volume was observed in IC552513 (57.12 m3). Leaf length ranged from 7.5 cm to 10.24 cm, leaf breadth varied from 3.18 cm to 4.78 cm and leaf area varied from 19.87 cm2 to 34.53 cm2 among different genotypes. Significant difference was recorded with respect to fruit characters among the yielding genotypes. Genotype ACC.FSC-6 exhibited significantly higher fruit weight (40.14 g), fruit volume (45.60 cm³), fresh weight of rind (21.01 g), and dry weight of rind (3.07 g). Conversely, genotype ACC.FSC-3 displayed significantly lower fruit weight (12.17 g), fruit volume (15.10 cm³), fresh weight of rind (7.15 g), and dry weight of rind (1.09 g). The rind to seed ratio ranged from 0.81 to 1.77, while rind thickness varied between 2.46 mm and 3.41 mm. Genotype ACC.FSC-9 exhibited the highest number of fruits per tree (2258) and the highest fruit yield per tree (60.64 kg). On the other hand, genotype ACC.FSC-3 recorded the lowest number of fruits per tree (252) and the lowest fruit yield per tree (3.07 kg). The moisture content varied from 82.91 % to 90.34 %, titratable acidity ranged from 2.30 % to 4.47 %, total sugars ranged from 4.32 % to 10.60 %, TSS ranged from 5.65 °B to 14.15 °B, and anthocyanin content ranged from 11.13 to 25.01 mg per 100 g. Genotypes IC552528-3 and IC336687-3 had significantly high TSS and low acidity were ranked as superior quality genotypes and these genotypes can be utilized for value addition.
Effect of Plant Growth Regulators on Nutrient and Quality Changes in Zingiber officinale Rosc
Authors: Saljuna K. P. , Thankamani C. K. , Alagupalamuthirsolai M. , Krishnamurthy K. S. , Pavithran Gayathri
Published: February 2024

Ginger is one of the oldest and renowned commercial spices well known for its medicinal and pharmaceutical value. Land degradation, availability of the quality rhizomes and diseases are some of the challenges faced in the ginger production. Since the productivity of a plant is influenced by a complex physiological process controlled by plant growth hormone balancing systems, the application of the growth regulators can have positive effect. Manipulating the PGR combinations and concentrations can lead to better quality and productivity in ginger. Hence, an experiment was conducted to study the effect of different plant growth regulators (PGRs) on nutrient and quality parameters in the ginger variety IISR Varada. Foliar spray of PGRs with 6-benzyl adenine purine (6-BAP), cycocel (Chlormequat chloride), gibberellic acid (GA) and paclobutrazol (PBZ) with five concentrations viz., 50ppm, 100ppm, 150ppm and 200ppm were applied 4th month after planting and water spray treated as control. Nutrients composition and biochemical components were observed on 5th month after planting and oleoresin was observed in the rhizomes after harvest. The results of pooled data over two years revealed that GA at 100 ppm recorded maximum nitrogen and chlorophyll content in leaves, potassium and protein in rhizomes. Regarding the oil content, maximum was noticed in treatment 100ppm Paclobutrazol followed by GA 100ppm.
“Vou aprender a ler para ensinar meus camaradas”: a salvaguarda do Samba de Roda do Recôncavo Baiano
Authors: Bandeira Rívia , Rosário Rosildo
Published: February 2024

O presente artigo analisa a execução do plano de salvaguarda do Samba de Roda do Recôncavo Baiano, bem cultural imaterial registrado como Patrimônio Cultural do Brasil pelo Iphan e inscrito na lista de Patrimônio Cultural da Humanidade da Unesco. Destaca-se o contexto e os desdobramentos da atuação do Estado e da sociedade civil em relação à salvaguarda do bem cultural, sobretudo o papel desempenhado por sambadores e sambadeiras na articulação de políticas públicas. Os dados foram coletados por meio de pesquisa empírica realizada no Recôncavo Baiano e no Iphan. A partir da apresentação das ações realizadas serão abordados os resultados alcançados, assim como os desafios que precisam ser superados para uma atuação efetiva na salvaguarda do patrimônio cultural imaterial.
Structural Characteristics of Steel Pipe Piles Using CLSM
Authors: Kim Euihun , Park Sungjin
Published: February 2024

Recently, as underground construction becomes larger and deeper, temporary facilities must be designed, and methods suitable for the construction environment, such as the shape of surrounding structures and ground conditions, must be applied. Among them, the importance of self-contained earth retaining wall temporary facility construction is growing. Therefore, the installation method and construction technology of the self-contained earth retaining wall temporary facility structure must be improved. In this study, to evaluate the structural behavior of steel pipe piles for self-contained earth retaining wall, a full-scale specimen was fabricated, the steel pipe ends were welded with round steel plates, and CLSM was filled through the sand compaction inside the steel pipe. Subsequently, compressive and flexural strength tests were conducted on the specimen in which both ends of the steel pipe were welded with round steel plates. Additionally, a finite element analysis of the vertical displacement of the bending specimen according to the load was performed based on the results from the ANSYS finite element analysis, and the results were compared.