bluuebunny/crossref_metadata_2025 huggingface dataset:
Daño de sol y potencial hídrico de tallo y tejidos del fruto de manzanas (Malus domestica) ‘Brasil Gala’, ‘Cripps Pink’ y ‘Granny Smith’
Authors: Severino Vivian , Dogliotti Santiago , Echeverría Gerardo , Frins Erna , González-Talice Jaime , Yuri José Antonio , Arias-Sibillotte Mercedes
Published: February 2024

Los descartes por desórdenes fisiológicos y daños mecánicos llegan a superar el 50% de la producción de manzana en zonas con clima neotropical como Uruguay. Son daños generalmente visibles durante la maduración y el almacenamiento, pero dependen de factores que suceden en el campo. El quemado de sol se presenta en algunas temporadas como uno de los principales defectos de calidad y ha sido relacionado históricamente con altos valores de radiación y temperatura y más recientemente con el estado hídrico de los tejidos del fruto y del árbol. El presente estudio evaluó la relación del daño por sol con la condición hídrica de tejidos de fruta en Brasil Gala, Cripps Pink y Granny Smith, así como el efecto de los tratamientos para evitar el daño por sol (malla negra 50%, malla blanca translúcida 20% y aplicación de caolinita) sobre el potencial hídrico de tallo en Granny Smith. El potencial hídrico del fruto disminuyó a lo largo del ciclo de crecimiento. En los frutos ubicados en el exterior del árbol, las caras expuestas presentaron valores menores de potencial hídrico de fruto que las caras no expuestas. El efecto sobre el potencial hídrico de los tratamientos para evitar el quemado de sol solo pudo constatarse en el caso de la malla negra 50 %.
Authors: Ferlina Nisa , Sugijati Sugijati , Kostania Gita
Published: February 2024

Pandemi Covid-19 telah menghambat program Posyandu di banyak daerah di Indonesia. Menurut survei Kementerian Kesehatan terhadap lebih dari 4.600 Puskesmas pada penghujung 2020, sebanyak 43% Puskesmas tidak melaksanakan Posyandu.(Kemenkes RI,2020). Tujuan dari penelitian ini adalah mengetahui hubungan kinerja kader kesehatan dengan kepuasan ibu dalam pelayanan Posyandu balita Mawar II Kelurahan Bareng Kota Malang pasca pandemi. Jenis penelitian ini adalah analitik korelasi dengan pendekatan cross sectional. Sampel pada penelitian ini sebagian ibu balita di wilayah posyandu Mawar II sebanyak 40 orang ibu balita dengan teknik pengambilan sampel total sampling. Instrumen yang digunakan untuk pengumpulan data dari variabel penelitian ini adalah kuesioner kinerja kader kesehatan dengan kepuasan ibu balita dengan soal pertanyaan dengan rating scale. Periode pengambilan data dilaksanakan tanggal 25 Juli - 1 Agustus 2023.Hasil penelitian, terdapat hubungan yang cukup kuat antara kinerja kader kesehatan dengan tingkat kepuasan ibu balita di Posyandu Mawar II Kota Malang dengan koefisien korelasi dari hasil penelitian ini adalah 0,629 dengan arah korelasi positif, semakin baik kinerja kader kesehatan maka akan semakin tinggi tingkat kepuasan ibu balita. Dari hasil penelitian ini diharapkan dapat meningkatkan kinerja kader dalam melakukan pelayanan tentang perannya kader untuk mencapai suatu tujuan yaitu meningkatkan kesehatan balita.
Pengukuran Kinerja Model Klasifikasi dengan Data Oversampling pada Algoritma Supervised Learning untuk Penyakit Jantung
Authors: Masruriyah Anis , Novita Hilda , Sukmawati Cici , Ramadhan Angga , Arif Siti , Dermawan Budi
Published: February 2024

Penyakit jantung tetap menjadi penyebab utama kematian di Indonesia dan dunia. Dalam data mining, ketidakseimbangan kelas antara sampel penyakit jantung dan normal dalam dataset adalah masalah serius. Hal ini dapat mengarah pada bias model ke arah kelas mayoritas, mengakibatkan kinerja buruk dalam mengidentifikasi kasus penyakit jantung yang lebih sedikit. Penelitian ini mengatasi masalah ini dengan menerapkan teknik oversampling, khususnya Synthetic Minority Over-sampling Technique (SMOTE) dan Adaptive Synthetic Sampling (ADASYN). Hasilnya menunjukkan bahwa model tanpa oversampling mencapai akurasi dan presisi di atas 80%, namun memiliki kinerja yang buruk dalam memisahkan kelas. Model yang memanfaatkan oversampling, meskipun dengan penurunan akurasi dan presisi, berhasil meningkatkan kemampuan dalam membedakan kelas penyakit jantung dan normal. Model terbaik menggunakan algoritma Random forest dengan SMOTE mencapai nilai AUC sebesar 0.868, menandakan peningkatan yang signifikan dalam pemisahan kelas. Temuan ini memberikan panduan penting bagi pengembangan model klasifikasi penyakit jantung yang lebih efektif dan akurat. Penggunaan teknik oversampling, seperti SMOTE, terbukti menjadi strategi yang efektif untuk mengatasi ketidakseimbangan kelas dalam data mining penyakit jantung. Meskipun akurasi dan presisi dapat mengalami penurunan, kemampuan model dalam mengidentifikasi penyakit jantung menjadi lebih andal, dengan hasil yang diukur menggunakan AUC yang signifikan. Penelitian ini berkontribusi pada upaya meningkatkan pencegahan dan pengobatan penyakit jantung melalui teknik data mining yang canggih dan berkelanjutan.
Analisa Performasi Metode Client Side Rendering, Server Side Rendering, dan Incremental Static Regeneration dalam Proses Website Rendering
Authors: Ardiyanto Roni , Ardhianto Eka
Published: February 2024

Website telah menjadi bagian penting dari kegiatan bisnis, pendidikan, hiburan, maupun media sosial. Optimalisasi website menjadi penting saat proses pembuatannya. Hal ini disebabakan supaya pengguna website merasa nyaman. Akses website yang cepat dan ringan menjadi salah satu daya tarik pengguna. Metode pembuatan website pada bagian frontend diklasifikasikan menjadi 3 macam, yaitu: metode CSR (Client Side Rendering), metode SSR (Server Side Rendering), dan metode ISR (Incremental Static Regeneration). Tujuan penilitian ini untuk mencari metode mana yang optimal digunakan dalam pengembangan website. Sebagai metrik performansi digunakan kecepatan dan ukuran website. Hasil yang diperoleh berupa perbandingan ukuran website dan waktu akses website.
Pemanfaatan Minyak Jelantah sebagai Lilin Aroma Terapi untuk Meningkatkan Minat Berwirausaha Pemuda Muhammadiyah Desa Batu Belah
Authors: Dahlia Agus , Qudsi Rahma , Purnamawati Neneng , Rahmatillah Putri
Published: February 2024

This service activity aims to increase the entrepreneurial interest of Muhammadiyah Youth members in Batu Belah Village, Kampar District, Kampar Regency, by utilizing community waste, namely used cooking oil which is disposed of in the surrounding environment. The method used is to provide training in processing used cooking oil into aromatherapy candles. From the training provided, it is hoped that it will create a new entrepreneur in the partner environment so that it can increase the income of its members.
Penggunaan Media Audio Visual untuk Meningkatkan Kemampuan Berbahasa Inggris
Authors: Ajiza Masrurotul , Arafah Feny
Published: February 2024

Penggunaan media akan sangat berpengaruh terhadap hasil akhir sebuah pembelajaran. Kegiatan pendampingan ini bertujuan untuk mendeskripsikan manfaat media audio visual pada pembelajaran bahasa inggris serta untuk mengetahui persepsi siswa terhadap penggunaan media audio visual. Hal ini disesuaikan dengan permasalahan yang ada pada mitra yakni tidak adanya media yang dapat membantu anak-anak dalam meningkatkan kemampuan berbahasa Inggris mereka. Adapun kegiatan abdimas ini dilaksanakan di desa Kauman, Wonorejo, Pasuruan sebagai mitra yang digandeng oleh peneliti. Hasil dari kegiatan ini menunjukkan bahwa pihak mitra bisa mengembangkan kemampuan putra-putri mereka dalam bidang bahasa Inggris  sehingga mampu membantu meningkatkan soft skill mereka.
Sosialisasi Sertifikasi Halal untuk UMKM Any Syafaat Bakery dan Bill Bakery
Authors: Faza Iqbal , Sekarningtyas Hikmah , Christanto Muhammad Steven Jonathan Risky , Septianawati Gunnarti -
Published: February 2024

Seiring dengan pertumbuhan jumlah penduduk, kebutuhan akan pangan semakin meningkat. Disisi lain, semakin membaiknya pemahaman masyarakat akan agama dan kesehatan, menjadikan permintaan masyarakat akan produk halal semakin meningkat. Sehingga, adanya sertifikasi halal memiliki posisi yang sangat penting, untuk memastikan barang-barang yang dikonsumsi telah memenuhi standar kelayakan dan sesuai dengan syarat-syarat kehalalan menurut syariat Islam. Hal ini wajib dipenuhi oleh semua pelaku usaha yang memproduksi barang-barang yang dikonsumsi oleh masyarakat tanpa terkecuali, termasuk UMKM. Namun demikian, pemahaman tentang prosedur memperoleh sertifikasi kehalalan produk masih jarang dipahami oleh UMKM. Pemahaman para pelaku usaha UMKM tentang bagaimana mendapatkan sertifikat kehalalan produknya masih sangat rendah. Pengabdian masyarakat ini bertujuan untuk memberikan pemahaman kepada para pengusaha UMKM dibidang makanan dan minuman mengenai pentingnya sertifikasi halal sekaligus memberikan panduan bagaimana cara mengajukan sertifikat halal dan dapat menjadi percontohan bagi UMKM lainnya khususnya di bidang makanan dan minuman di Kabupaten Kudus. Program ini melibatkan mitra yaitu Bill Bakery di Kecamatan Kota Kabupaten Kudus dan Any Syafaat Bakery di Kecamatan Gebog Kabupaten Kudus. Setelah program ini terlaksana, diharapkan para mitra pelaku usaha tersebut telah memiliki pemahaman tentang bagaimana mengurus sertifikat halal. Tindak lanjut kegiatan ini adalah pendampingan sampai kedua mitra tersebut benar-benar dapat memiliki sertifikat halal.
Peningkatan Pemahaman Masyarakat dalam Aktivitas Konservasi Mangrove Segara Anakan Melalui Sosialisasi dan Simulasi Penentuan Variabel Penting
Authors: Hilmi Endang , Prayogo Norman Arie , Junaidi Teuku , Dewi Rose , Fianjani Ajeng Sekar
Published: February 2024

Penentuan variabel penting merupakan hal yang sangat diperlukan untuk mengelola secara lestari dari ekosistem mangrove dan laguna Segara Anakan. Penentuan variabel penting tersebut dilakukan melalui aktivitas FGD dengan beberapa stakeholder yang berperan dalam pengelolaan ekosistem mangrove dan laguna Segara Anakan. Aktivitas ini bertujuan untuk meningkatkan pemahaman stakeholder dalam pengelolaan ekosistem Segara Anakan dilakukan dengan menggunakan simulasi MICMAC. Aktivitas sosialisasi dan simulasi dilakukan dengan melibatkan stakeholder yang dikelompokan menjadi beberapa cluster pelaku yaitu pemerintah (baik pemda maupun dinas), perangkat dan aparat desa, masyarakat, industri (pertamina, industry semen dan pembangkit listrik), andong perahu dan beberapa pakar.   Hasil simulasi dan sosilasisasi meningkatkan pemahaman masyarakat melalui penentuan variabel utama yaitu tsunami, ROB, limbah, abrasi, sedimentasi, dan pencemaran, tambak dan perubahan fishing ground. Variabel tersebut  menjadi variabel utama yang sangat mempengaruhi keberlanjutan ekosistem mangrove dan laguna Segara anakan
Pelatihan dan Edukasi Strategi Pemasaran Produk Olahan Tepung “Akar Kelapa” Sebagai Upaya Melestarikan Produk Berbasis Keunggulan Daerah dan Meningkatkan Ekonomi Masyarakat di Kelurahan Marga Mulya Kota Bekasi
Authors: Giningroem Dewi Sri Woelandari Pantjolo , Wijayanti Murti , Yunita Tyna , Setyawati Novita Wahyu
Published: February 2024

Usaha kecil dan industri rumah tangga belakangan ini memainkan peranan penting dalam meningkatkan ekonomi masyarakat khususnya mendukung pendapatan rumah tangga. Usaha rumahan produk olahan tepung “akar kelapa” saat ini sulit didapatkan karena diproduksi terutama pada saat Hari Raya. Pelatihan strategi pemasaran bertujuan melestarikan produk lokal dan meningkatkan pemahaman akan pentingnya strategi pemasaran dalam usaha. Pengabdian ini bertujuan edukasi tentang strategi pemasaran untuk menjaga produk lokal dan mendukung ekonomi, terutama industri rumahan.Kegiatan ini melibatkan Ibu-Ibu rumah tangga di Kelurahan Marga Mulya RT 005/ RW 01 Kota Bekasi dengan metode ceramah dan praktek. Tujuannya adalah meningkatkan kemampuan mereka dalam membuat produk olahan tepung “akar kelapa” melalui strategi pemasaran dan kemasan modern, menjaga keunggulan produk daerah serta meningkatkan daya saing.
Strategi Promosi Pemasaran Wisata Kolam Renang Desa Walando guna Meningkatkan Potensi Desa Wisata (PkM pada Bumdes Desa Walando Buton Tengah)
Authors: Rais Muhammad , Agustyawati Dwi , Mahmuda Dewi
Published: February 2024

Desa Walando, Kecamatan Gu, Kabupaten Buton Tengah merupakan salah satu desa yang berupaya untuk mengembangkan potensinya sehingga ada pemasukan bagi pemerintah desa melalui BUMDes. Potensi Desa Walando yang dikembangkan adalah berupa wisata kolam renang. Banyaknya usaha bisnis yang dilakukan oleh BUMDes Desa Walando maka diperlukan strategi pemasaran untuk menarik para wisatawan untuk mau berkunjung ke wisata kolam renang desa Walando. Tujuan pendampingan ini adalah agar Masyarakat desa Walando khususnya pengurus BUMDes desa Walando lebih memahami strategi promosi pemasaran wisata. Kegiatan PKM dilakukan melalui metode pelatihan dan juga pendampingan yang diikuti oleh para pengelola wisata, pengurus BUMdes dan perangkat Desa Walando. Hasil yang diperoleh dari kegiatan pendampingan ini adalah bertambahnya tingkat pengetahuan dan pemahaman pengurus BUMDes dan masyarakat tentang strategi promosi pemasaran wisata kolam renang dalam meningkatkan potensi daerah
PENERAPAN MODEL COOPERATIVE INTEGRATED READING AND COMPOSITION PADA PEMBELAJARAN BAHASA INDONESIA KELAS IV SD NEGERI 68 LUBUKLINGGAU
Authors: Padila Padila , Satinem Satinem , Aswarliansyah Aswarliansyah
Published: February 2024

Abstrak: Penelitian ini bertujuan untuk mengetahui bagaimana peran dalam membentuk karakter dan pribadi yang luhur melalui pembentukan sikap, dengan menjadikan domain keterampilan dan kognitif. Jenis penelitian ini digunakan dalam penulisan karya ilmiah yang digunakan metode penelitian kualitatif dengan menggunakan metode pengumpulan data-data yang bersumber dari buku, jurnal, artikel, majalah dan internet. Dalam meningkatkan mutu lembaga berdasarkan proses pembelajaran dan mengembangkan kemampuan setiap individu. Penelitian ini untuk memperoleh gambaran pelaksanaan pembelajaran yang di akibatkan adanya pandemi Covid-19 dalam prespektif pendidikan, saat pandemi Covid-19 ini, penelitian ini melihat adanya proses pendidikan itu akan mempengaruhi peserta didik agar dapat menyesuaikan diri dengan lingkungan.
METHOD AND MEANS OF SECURITY MONITORING IN A COMPUTER NETWORK BY SIEM MEANS
Authors:   Vinnytsia National Technical University, Savytska Liudmyla , Korobeinikova Tetiana ,   National university “Lvivska Politechnika”, Volos Oleksandr ,   Vinnytsia National Technical University, Tarnovskyi Mykola ,   Vinnytsia National Technical University
Published: February 2024

This work focuses on researching, analyzing, and enhancing methods and tools for security monitoring in computer networks. The study develops security monitoring tools and methods based on SIEM agents, improving the data normalization process from security logs. The research explores SIEM's role in the SIEM-EDR-NDR triad perspective to accelerate responses to network security threats. The investigation is grounded in the experiences of foreign companies and domestic banking networks. The interaction of SIEM-EDR-NDR components, forming a SOC triad, is examined. SIEM is utilized for centralized data analysis, including EDR and NDR, providing a comprehensive security overview. EDR detects and responds to threats on endpoints, complemented by NDR, extending SIEM analysis. This combination ensures effective response to cyberattacks, reducing "dwell time" until detection. The formulation of tasks for EDR components in the SIEM-EDR-NDR triad is discussed. Emphasis is placed on the importance of protecting endpoints at all stages of an attack, and effective strategies, such as traffic analysis, application control, and centralized cybersecurity management, are identified. Integration of EDR with existing security tools to create a comprehensive system is highlighted. Within the SIEM context, data processing stages, from log collection and normalization to event classification and correlation, are illuminated. The role of correlation in incident formation and investigation is underscored. An enhanced normalization scheme with an expanded agent deployment and key data processing stages within the SIEM system is proposed. The work addresses the improvement of event log processing in SIEM for effective network security monitoring and timely threat mitigation. The achieved goal accelerates threat response processes through SIEM agent integration, facilitating the organization and classification of information flows for prompt threat mitigation.
ANALYSIS OF PROMOTION OF 5G TECHNOLOGY IN THE WORLD AND EXPECTATIONS FOR UKRAINE
Authors:   Ivan Kozhedub Kharkiv National Air Force University, Lytvynenko Mykhailo , Harmash Nataliia ,   Ivan Kozhedub Kharkiv National Air Force University
Published: February 2024

The article analyzes the promotion, advantages and assessment of the achievements of 5G technology in the world, the available results of the implementation of 5G in various sectors of the economy despite the problems with its rapid development. The growing needs for speed and bandwidth of data transmission, increasing the number of connected devices without loss of communication quality, reducing delays and increasing reliability in conducting remote operations in real time, the development of innovations such as the Internet of Things (IoT), augmented reality ( AR) and virtual reality (VR), autonomous vehicles and the industrial sector, in particular on industrial automation and "smart" factories, the use of high-performance sensors and real-time robotics. The advantages of 5G technology, characterized by high data transfer speed, low support (latency), large network capacity, and improved mobility, are given. Episodes of the use of 5G in the military field in real time are described, to instantly store and reproduce large volumes of video and graphics, smart cities that use 5G to support a large number of sensors and sensors in the city, to implement a variety of services, energy management, public transport monitoring. Considered, the relevance of using the 5G mobile network in Ukraine remains high. The necessary steps in Ukraine from the development of standards, the allocation of frequencies, the creation of infrastructure and the acquisition of the necessary number of devices that support 5G are considered. A forecast of expected results such as infrastructure expansion is provided; access to a wide range of frequencies, including low and high bands; the ability to resist cyber attacks from a wide range of sources; energy efficient; compatible with existing infrastructure and other communication protocols. It was concluded that the introduction of the 5G network as soon as possible will provide an impetus for Ukraine from a technical and economic point of view.
Impact of Emotional Intelligence on Teacher's Performance in Higher Education Institutions in Pakistan
Authors: Jamal Bakht , Khan Muhammad Hamid Nawaz , Shah Sultan Akbar
Published: February 2024

This study examines how emotional intelligence affects higher education teachers in Pakistan. Emotional intelligence shapes teacher-student relationships and classroom dynamics. The quantitative descriptive research design was adopted for the study. The respondents were 350 teachers from higher education institutions. The data were collected through a questionnaire to determine how emotional intelligence affects classroom management, communication, and teacher-student relationships. The data were analyzed by applying Pearson correlation and Regression Analysis. The findings reveal significant positive correlations between emotional intelligence and classroom management practices (r = 0.62) and effective communication skills (r = 0.68). Additionally, there is a moderate to strong positive correlation (r = 0.68) between emotional intelligence and teacher-student relationships. The regression analysis confirms emotional intelligence significantly predicts the quality of teacher-student relationships (β = 0.50, p < 0.001). The findings emphasize the relevance of emotional intelligence in higher education teachers to increase performance and provide a more supportive learning environment. Emotional intelligence training in teacher education and professional development can improve Pakistani education.
An Analysis of the Deforming Tendencies in the English Translation of Zama Jwand Aw Jidojehad by Imtiaz Ahmad Sahibzada
Authors: Khan Asif , Ahmad Israr , Zaib Kamran
Published: February 2024

This thesis analyses the English translation "My Life and Struggle" by Imtiaz Ahmad Sahibzada, of the Pashto text "Zama Jwand Ao Jidojehad" by Khan Abdul Ghaffar Khan. In the current study "Zama Jwand Ao Jidojehad" is the source text, while "My life and struggle" is the target text for analysis. Selected excerpts of the said books are extracted for translation purposes. It adopts a qualitative method and close reading technique for the analysis of this study. Antoine Berman's twelve Deforming Tendencies is used as a theoretical modal for this study. It highlights that there are deforming tendencies in the source text's English translation.
Effectiveness of Teaching Practices of Teaching English: A Comparison of Public and Private Schools Faisalabad Districts
Authors: Rashid Sumera , Akhtar Noreen
Published: February 2024

This article explores the effectiveness of teaching practices in English instruction in Faisalabad District, comparing the approaches employed by public and private schools. The study adopts a comparative research design to analyze the teaching practices in English instruction between 10 public and 10 private schools. A stratified sampling technique is used to ensure representation from 10 public schools’ English teachers and 10 private schools’ English teachers. The results can guide efforts to improve teaching practices, allocate resources effectively, and enhance the overall quality of English education in private and public schools. The article concludes by emphasizing the need for collaborative efforts to bridge the gap, ensuring equitable access to high-quality English education for all students in the region. Policymakers should address the high fees charged by private schools, which can exclude many students from low-income families. This could involve providing scholarships or implementing policies to make private schools more accessible.
Sacred Spaces on Screen: Redefining African Shrines in Nollywood’s Global Narrative
Authors: Emmanuel Nzas
Published: February 2024

This research paper delves into the portrayal of African shrines in Nollywood, Africa’s largest movie industry, with a focus on rectifying the incomplete representation of these sacred spaces. The paper emphasizes the profound role that shrines play in shaping the lives of Africans, predating the advent of foreign religions in Nigeria, a nation deeply rooted in religious consciousness. Recommendations are presented, urging a critical review by the federal government and regulatory bodies overseeing the Nigerian movie industry to ensure a comprehensive and accurate portrayal of African cultural heritage. Additionally, the creative industry is encouraged to use forums judiciously to maintain a genuine African identity, especially concerning shrines. Academic departments in theater arts and cultural studies are urged to champion authentic representation, empowering future creators to preserve African identity amidst evolving global cinematic trends. The paper concludes by underscoring the significant responsibility of Nollywood in shaping perceptions of African culture and advocating for a more accurate depiction of African shrines on the global stage, aligning with broader goals of promoting cultural appreciation and sustainable development.
Improving Students’ Speaking Skill through Play-Based Learning
Authors: Andreas Aan , Regina Regina , Riyanti Dwi
Published: February 2024

Based on the syllabus on 4.8, 10-year students at Sekolah Menengah Kejuruan (SMK) Maniamas Ngabang must be able to present short and simple narrative texts related to folk legends. This research aims to improve students’ speaking skills through play-based learning. This research was a classroom action research. The procedures of this research covered planning, acting, observing and reflecting. The subjects of this research were 28 students of class X of SMK Maniamas Ngabang. The data were collected by observation checklist, field notes, speaking test, questionnaire, and interview sheet. The data obtained from the process of data collection were analyzed by reflecting on the facts or information gathered to assess the improvement of students' speaking. After collecting the data, the next step was analyzed the data. The data classified based on the research. In this study, the analysis used qualitative and quantitative analysis. This research showed play-based learning was able to improve students’ speaking skills. The students were more engaged in learning when the lesson presented involved games, and they also put more concerned about their assignments, attendance, and activities during the learning process. They stated that it became easier to understand the lesson because they can directly practice it the game application in the learning process. Last, the questionnaire result showed the students strongly agreed that play-based learning was a good method for learning to speak, with a mean value 4.54. In conclusion, the use of play-based learning can improve students’ speaking skill.
Validity and Reliability Study of Online Cognitive Tracking Software (BEYNEX)
Authors: Çınar Nilgün , Aslan Kendirli Sude , Florentina Ateş Miruna , Yakupoğlu Ezgi , Akbuğa Ebru , Bolu Naci Emre , Karalı Fenise Selin , Okluoğlu Tuğba , Bülbül Nazlı Gamze , Bayindir Elif , Atam Kamil Tolga , Hisarlı Enis , Akgönül Sarp , Bagatır Oğulcan , Sahiner Emre , Orgen Bora , Sahiner Türker Ahmet Hasan
Published: February 2024

Background:

Detecting cognitive impairment such as Alzheimer’s disease early and tracking it over time is essential for individuals at risk of cognitive decline.

Objective:

This research aimed to validate the Beynex app’s gamified assessment tests and the Beynex Performance Index (BPI) score, which monitor cognitive performance across seven categories, considering age and education data.

Methods:

Beynex test cut-off scores of participants ( n = 91) were derived from the optimization function and compared to the Montreal Cognitive Assessment (MoCA) test. Validation and reliability analyses were carried out with data collected from an additional 214 participants.

Results:

Beynex categorization scores showed a moderate agreement with MoCA ratings (weighted Cohen’s Kappa = 0.48; 95% CI: 0.38–0.60). Calculated Cronbach’s Alpha indicates good internal consistency. Test-retest reliability analysis using a linear regression line fitted to results yielded R∧2 of 0.65 with a 95% CI: 0.58, 0.71.

Discussion:

Beynex’s ability to reliably detect and track cognitive impairment could significantly impact public health, early intervention strategies and improve patient outcomes.
Education and Literacy as Risk Factors of Dementia after Stroke and Transient Ischemic Attack: NEDICES Study
Authors: Contador Israel , Alzola Patricia , Bermejo-Pareja Félix , del Ser Teodoro , Llamas-Velasco Sara , Fernández-Calvo Bernardino , Benito-León Julián
Published: February 2024

Background: A protective effect of education on cognitive decline after stroke has been claimed, but evidence from prospective population-based cohorts is very limited. The differential role of literacy and education on dementia after stroke remains unexplored. Objective: This research addresses the role of education and literacy in dementia incidence after stroke and transient ischemic attack (TIA). Methods: 131 participants with stroke or TIA were identified within the population-based NEDICES study (N = 5,278 persons). Participants were fully assessed at baseline (1994–1995) and incident dementia diagnosis was made by expert neurologists (DSM-IV criteria) after a mean follow-up of 3.4 years. Adjusted Cox regression analyses were applied to test the association between education, literacy, and dementia risk. Results: Within the 131 subjects with stroke or TIA, 19 (14%) developed dementia at follow-up. The Cox’s regression model (age and sex adjusted) showed that low education (HR = 3.48, 95% CI = 1.28, 9.42, p = 0.014) and literacy (HR = 3.16, 95% CI = 1.08, 9.22, p = 0.035) were significantly associated with a higher dementia risk. Low education was also associated with dementia when main confounders (i.e., cognitive/functional performance) were considered in the Cox’s model. However, after including stroke recurrence, only low/null literacy (versus education) remained as significant predictor of dementia. Finally, low/null literacy showed an effect over-and-above education on dementia risk when both factors were introduced in the adjusted Cox’s regression. Conclusion: These findings underline the importance of literacy to estimate cognitive decline after stroke in low-educated populations.
Validation of a Computerized Cognitive Training Tool to Assess Cognitive Impairment and Enable Differentiation Between Mild Cognitive Impairment and Dementia
Authors: Liu Li-Yang , Xing Yi , Zhang Zi-Heng , Zhang Qing-Ge , Dong Ming , Wang Haibo , Cai Longjun , Wang Xiaoyi , Tang Yi
Published: February 2024

Background: Age-related cognitive decline is a chronic, progressive process that requires active clinical management as cognitive status changes. Computerized cognitive training (CCT) provides cognitive exercises targeting specific cognitive domains delivered by computer or tablet. Meanwhile, CCT can be used to regularly monitor the cognitive status of patients, but it is not clear whether CCT can reliably assess cognitive ability or be used to diagnose different stages of cognitive impairment. Objective: To investigate whether CCT can accurately monitor the cognitive status of patients with cognitive impairment as well as distinguish patients with dementia from patients with mild cognitive impairment (MCI). Method: We included 116 patients (42 dementia and 74 MCI) in final analysis. Cognitive ability was assessed by averaging the patient performance on the CCT to determine the Cognitive Index. The validity of the Cognitive Index was evaluated by its correlation with neuropsychological tests, and internal consistency was measured to assess the reliability. Additionally, we determined the diagnostic ability of the Cognitive Index to detect dementia using receiver operating characteristic (ROC) analysis. Results: The Cognitive Index was highly correlated with the Montreal Cognitive Assessment (r = 0.812) and the Mini-Mental State Examination (r = 0.694), indicating good convergent validity, and the Cronbach’s alpha coefficient was 0.936, indicating excellent internal consistency. The area under the ROC curve, sensitivity, and specificity of the Cognitive Index to diagnose dementia were 0.943, 83.3%, and 91.9%, respectively. Conclusions: CCT can be used to assess cognitive status and detect dementia in patients with cognitive impairment.
Using mHealth for Primary Prevention of Dementia: A Proof-of-Concept Study on Usage Patterns, Appreciation, and Beliefs and Attitudes Regarding Prevention
Authors: Heger Irene , Deckers Kay , de Vugt Marjolein , Verhey Frans , Oenema Anke , van Boxtel Martin , Köhler Sebastian
Published: February 2024

Background: Health- and lifestyle factors account for a substantial part of all dementia cases, which opens the opportunity for primary prevention. However, the required behavioral change is complex and involves targeting multiple risk factors. mHealth interventions can potentially contribute to improving motivation in a low-cost and scalable way. Objective: To explore usage patterns, appreciation, and beliefs and attitudes regarding dementia risk reduction during the use of the MyBraincoach mobile app. Methods: Participants were community-dwelling middle-aged adults from the Netherlands and used either the standard (education) or extended (education+motivational triggers) app version for three months. Two panel studies were combined in this paper. Chi-square tests, t-tests and linear mixed models were used, adjusted for age, sex, and education. Results: Of all participants (n = 299, 50.2% male), 167 (55.9%) had installed the app. The most reported reason for non-use was technical problems (47%). Those who used the app were at baseline already more positive about dementia risk reduction than those who did not use the app. Of all users who completed the evaluation (n = 102), 78.4% (n = 80) stated that the app provided a positive approach towards brain health and 80.4% (n = 82) felt better informed. Younger (<60y) and lower educated participants evaluated the app most positively. Conclusion: Usage of the app was low, but users showed more positive beliefs and attitudes regarding dementia risk reduction. Most users evaluated the app positively and stated to have gained knowledge on the topic. Improving the use of the app must keep high priority in future studies.
Multidimensional Sleep Health and Long-Term Cognitive Decline in Community-Dwelling Older Men
Authors: Cavaillès Clémence , Yaffe Kristine , Blackwell Terri , Buysse Daniel , Stone Katie , Leng Yue
Published: February 2024

Specific sleep characteristics have been associated with cognitive decline, Alzheimer’s disease, and related dementias; however, studies examining the association between multidimensional sleep (a more comprehensive integration of sleep parameters) and cognitive decline are lacking. Among 2,811 older men without dementia, those with none, 1-2, and 3–5 “poor” self-reported sleep health dimensions had an adjusted 10-year change score of global cognition (3MS) of 2.9, 4.0 and 3.5 points (p-trend = 0.05), and in executive function (Trails B) completion time of 36.7, 42.7, and 46.7 seconds (p-trend < 0.01), respectively. In conclusion, a multidimensional measure of sleep health was associated with greater cognitive decline.
Chronic Alcohol Exposure Alters Gene Expression and Neurodegeneration Pathways in the Brain of Adult Mice
Authors: Liu Mingjing , Guo Shipeng , Huang Daochao , Hu Dongjie , Wu Yili , Zhou Weihui , Song Weihong
Published: February 2024

Background: Chronic alcohol consumption can alter the structure of the central nervous system and disrupt cognitive function. Alcoholics are more likely to develop neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). However, the role of alcohol in promoting neurotoxicity and neurodegeneration remains unclear. Objective: In this study, we aimed at estimating the effects of chronic binge alcohol exposure on brain transcriptome and behavior changes in a chronic “Drinking in the Dark” (DID) mouse model. Methods: The adult C57BL/6J male mice were exposed to alcohol for 4 weeks. RNA-seq was applied to assess the effects of chronic alcohol exposure on transcriptome in brain. The open field test and novel object recognition test were used to assess the changes of anxiety level, locomotive function, and short-term memory induced by alcohol. RNA-seq analysis revealed that chronic alcohol exposure caused significant change in the brain transcriptome, especially in prefrontal cortex. Results: The gene dysregulation caused by chronic alcohol exposure includes pathways related to mitochondrial energy metabolism (such as oxidative phosphorylation) and multiple neurodegenerative diseases (such as AD and PD). Furthermore, the pathway and network analyses suggest that the genes involved in mitochondrial energy metabolism, ubiquitin-proteasome system, Wnt signaling pathway, and microtubules may attribute to the neurotoxicity and neurodegeneration caused by chronic alcohol consumption. Additionally, locomotive function was also significantly impaired. Conclusion: This work provides gene transcriptional profile data for future research on alcohol-induced neurodegenerative diseases, especially AD and PD.
Putative Alcohol-Related Dementia as an Early Manifestation of Right Temporal Variant of Frontotemporal Dementia
Authors: Funayama Michitaka , Nakajima Asuka , Kurose Shin , Takata Taketo
Published: February 2024

Diagnosis of frontotemporal dementia is challenging in the early stages. Various psychiatric and neurological diseases are misdiagnosed as frontotemporal dementia and vice versa. Here we present a case with right temporal variant of frontotemporal dementia who presented with alcohol dependency and remarkable behavioral symptoms and was first misdiagnosed as having alcohol-related dementia. He then revealed symptoms related to right temporal variant of frontotemporal dementia, such as prosopagnosia, difficulty recognizing his housemates, loss of empathy, ritualistic behaviors, and difficulty finding and comprehending words. Retrospectively, his alcohol dependency itself was considered an early manifestation of right temporal variant of frontotemporal dementia.
Association Between Elevated Depressive Symptoms and Cognitive Function Moderated by APOE4 Status: Framingham Offspring Study
Authors: Piers Ryan J. , Liu Yulin , Ang Ting F.A. , Tao Qiushan , Au Rhoda , Qiu Wei Qiao
Published: February 2024

Background: Depression and Apolipoprotein E4 (APOE4) are associated with decreased cognitive function and differences in brain structure. Objective: This study investigated whether APOE4 status moderates the association between elevated depressive symptoms, cognitive function, and brain structure. Methods: Stroke- and dementia-free participants (n = 1,968) underwent neuropsychological evaluation, brain MRI, and depression screening. Linear and logistic regression was used to examine all associations. Secondary analyses were performed using interaction terms to assess effect modification by APOE4 status. Results: Elevated depressive symptoms were associated with lower cognitive performance in several domains. In stratified analyses, elevated depressive symptoms were associated with poorer visual short- and long-term memory performance for APOE4 + participants. Elevated depressive symptoms were not associated with any brain structure in this study sample. Conclusion: Elevated depressive symptoms impact cognitive function in non-demented individuals. Having the APOE4 allele may exacerbate the deleterious effects of elevated depressive symptoms on visual memory performance. Screening for elevated depressive symptoms in both research studies and clinical practice may be warranted to avoid false positive identification of neurodegeneration, particularly among those who are APOE4 + .
Association Between Anxiety and Cognitive Decline Over 12 Years in a Population-Based Cohort
Authors: Kootar Scherazad , Huque Md Hamidul , Arthur Richard , Mortby Moyra , Anstey Kaarin J.
Published: February 2024

Background: Findings on the associations between anxiety and cognitive decline are mixed and often confounded. Objective: We studied whether anxiety symptoms were associated with the risk of cognitive decline after adequate adjustment of confounding factors. Methods: Our study consists of 2,551 community-dwelling older adults recruited between the ages of 60–64 years and followed up for 12 years in the PATH Through Life cohort study. Anxiety symptoms were measured using the Goldberg Anxiety Scale (GAS; range 0–9). General cognitive function, episodic memory, working memory, verbal intelligence, processing speed, and psychomotor speed were measured. Multilevel analyses were carried out to investigate the association between anxiety symptoms and cognitive decline over 12 years, taking into account confounding variables. Results: We did not find a significant association between baseline anxiety symptoms and cognitive decline over 12 years. Although some associations between anxiety symptoms with psychomotor speed (β = –0.04, 99% CI: –0.08, 0.00) and processing speed (β = –0.27, 99% CI: –0.48, –0.07) were found, these were attenuated after adjusting for depression. We also did not find an association between cumulative anxiety and decline in cognitive performance. Conclusion: In this sample of cognitively healthy men and women aged 60 years and above, anxiety symptoms were not associated with the risk of cognitive decline. Long follow-up study time, appropriate selection of confounding factors, and estimating the effect of cumulative anxiety are important to establish the association between anxiety and cognitive symptoms.
Young Adult Brain Capital: A New Opportunity for Dementia Prevention
Authors: Farina Francesca R. , Booi Laura , Occhipinti Jo-An , Quoidbach Vinciane , Destrebecq Frédéric , Muniz-Terrera Graciela , Eyre Harris A.
Published: February 2024

The potential for future prevention of Alzheimer’s disease and related dementias (ADRD) through healthy lifestyle change is spurring a positive brain health movement. However, most ADRD research continues to focus on mid- and later life. We lack evidence regarding risk exposure and protective factors in young adulthood, i.e., 18–39 years. Brain capital is an emerging framework that represents the combination of education, knowledge, skills, and optimal brain health that people accumulate over their lives. Building on this framework, we present a new model that focuses on optimizing brain health in young adulthood; namely, young adult brain capital. Increasing focus on younger populations is critical for developing citizens who are emotionally intelligent, resilient and can anticipate and cope with rapid changes in the world. By understanding the values that are key drivers and motivators for young adults, we can empower the next generation to become active agents in optimizing their brain health and reducing their risk for future ADRD.
Depressive and Biopsychosocial Frailty Phenotypes: Impact on Late-life Cognitive Disorders
Authors: Panza Francesco , Solfrizzi Vincenzo , Sardone Rodolfo , Dibello Vittorio , Castellana Fabio , Zupo Roberta , Stallone Roberta , Lampignano Luisa , Bortone Ilaria , Mollica Anita , Berardino Giuseppe , Ruan Qingwei , Altamura Mario , Bellomo Antonello , Daniele Antonio , Lozupone Madia
Published: February 2024

In older age, frailty is a detrimental transitional status of the aging process featuring an increased susceptibility to stressors defined by a clinical reduction of homoeostatic reserves. Multidimensional frailty phenotypes have been associated with all-cause dementia, mild cognitive impairment (MCI), Alzheimer’s disease (AD), AD neuropathology, vascular dementia, and non-AD dementias. In the present article, we reviewed current evidence on the existing links among depressive and biopsychosocial frailty phenotypes and late-life cognitive disorders, also examining common pathways and mechanisms underlying these links. The depressive frailty phenotype suggested by the construct of late-life depression (LLD) plus physical frailty is poorly operationalized. The biopsychosocial frailty phenotype, with its coexistent biological/physical and psychosocial dimensions, defines a biological aging status and includes motivational, emotional, and socioeconomic domains. Shared biological pathways/substrates among depressive and biopsychosocial frailty phenotypes and late-life cognitive disorders are hypothesized to be inflammatory and cardiometabolic processes, together with multimorbidity, loneliness, mitochondrial dysfunction, dopaminergic neurotransmission, specific personality traits, lack of subjective/objective social support, and neuroendocrine dysregulation. The cognitive frailty phenotype, combining frailty and cognitive impairment, may be a risk factor for LLD and vice versa, and a construct of depressive frailty linking physical frailty and LLD may be a good dementia predictor. Frailty assessment may enable clinicians to better target the pharmacological and psychological treatment of LLD. Given the epidemiological links of biopsychosocial frailty with dementia and MCI, multidomain interventions might contribute to delay the onset of late-life cognitive disorders and other adverse health-related outcomes, such as institutionalization, more frequent hospitalization, disability, and mortality.
Medical and Social Determinants of Brain Health and Dementia in a Multicultural Community Cohort of Older Adults
Authors: Galvin James E. , Chrisphonte Stephanie , Chang Lun-Ching
Published: February 2024

Background: Socioeconomic status (SES), race, ethnicity, and medical comorbidities may contribute to Alzheimer’s disease and related disorders (ADRD) health disparities. Objective: Analyze effects of social and medical determinants on cognition in 374 multicultural older adults participating in a community-based dementia screening program. Methods: We used the Montreal Cognitive Assessment (MoCA)and AD8 as measures of cognition, and a 3-way race/ethnicity variable (White, African American, Hispanic) and SES (Hollingshead index) as predictors. Potential contributors to health disparities included: age, sex, education, total medical comorbidities, health self-ratings, and depression. We applied K-means cluster analyses to study medical and social dimension effects on cognitive outcomes. Results: African Americans and Hispanics had lower SES status and cognitive performance compared with similarly aged Whites. We defined three clusters based on age and SES. Cluster #1 and #3 differed by SES but not age, while cluster #2 was younger with midlevel SES. Cluster #1 experienced the worse health outcomes while cluster #3 had the best health outcomes. Within each cluster, White participants had higher SES and better health outcomes, African Americans had the worst physical performance, and Hispanics had the most depressive symptoms. In cross-cluster comparisons, higher SES led to better health outcomes for all participants. Conclusion: SES may contribute to disparities in access to healthcare services, while race and ethnicity may contribute to disparities in the quality and extent of services received. Our study highlights the need to critically address potential interactions between race, ethnicity, and SES which may better explain disparities in ADRD health outcomes.
A Reliable Algorithm for Efficient Water Delivery and Smart Metering in Water-Scarce Regions
Authors: Marar Rosana W. , Marar Hazem W.
Published: February 2024

Smart water meters play a significant part in the interactive control of water supply networks required for smart cities. Opposed to completely mechanical water meters, electro-mechanical water meters or fully electronic water meters can capture real-time data via an automated meter reading process, making them more appropriate for smart city applications. However, the depletion of fresh water supplies as a result of climate change, as well as the rising demand associated with population increase, are some growing concern in many regions globally. Monitoring water distribution and delivery is a critical strategy for increasing distribution efficiency. This paper presents a wireless transceiver unit that can be integrated with existing electronic water meters. The unit utilises a reliable communication algorithm for real-time data exchange. Metering data is transmitted using cutting-edge narrow-band Internet of Things technology that operates using low power whilst covering a wide range with effective penetration.