bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeting Inhibition of Accumulation and Function of Myeloid-Derived Suppressor Cells by Artemisinin via PI3K/AKT, mTOR, and MAPK Pathways Enhances Anti-PD-L1 Immunotherapy in Melanoma and Liver Tumors
Authors: Zhang Mengqi , Wang Lulu , Liu Wan , Wang Tian , De Sanctis Francesco , Zhu Lifang , Zhang Guizhong , Cheng Jian , Cao Qin , Zhou Jingying , Tagliabue Aldo , Bronte Vincenzo , Yan Dehong , Wan Xianchun , Yu Guang
Published: June 2022

Despite the remarkable success and efficacy of immune checkpoint blockade (ICB) therapy such as anti-PD-L1 antibody in treating cancers, myeloid-derived suppressor cells (MDSCs) that lead to the formation of the protumor immunosuppressive microenvironment are one of the major contributors to ICB resistance. Therefore, inhibition of MDSC accumulation and function is critical for further enhancing the therapeutic efficacy of anti-PD-L1 antibody in a majority of cancer patients. Artemisinin (ART), the most effective antimalarial drug with tumoricidal and immunoregulatory activities, is a potential option for cancer treatment. Although ART is reported to reduce MDSC levels in 4T1 breast tumor model and improve the therapeutic efficacy of anti-PD-L1 antibody in T cell lymphoma-bearing mice, how ART influences MDSC accumulation, function, and molecular pathways as well as MDSC-mediated anti-PD-L1 resistance in melanoma or liver tumors remains unknown. Here, we reported that ART blocks the accumulation and function of MDSCs by polarizing M2-like tumor-promoting phenotype towards M1-like antitumor one. This switch is regulated via PI3K/AKT, mTOR, and MAPK signaling pathways. Targeting MDSCs by ART could significantly reduce tumor growth in various mouse models. More importantly, the ART therapy remarkably enhanced the efficacy of anti-PD-L1 immunotherapy in tumor-bearing mice through promoting antitumor T cell infiltration and proliferation. These findings indicate that ART controls the functional polarization of MDSCs and targeting MDSCs by ART provides a novel therapeutic strategy to enhance anti-PD-L1 cancer immunotherapy.
Association between Serum Potassium with Risk of Onset and Visual Field Progression in Patients with Primary Angle Close Glaucoma: A Cross-Sectional and Prospective Cohort Study
Authors: Qiu Yichao , Wei Jiaojiao , Yu Jian , Li Yingzhu , Shao Mingxi , Ren Jun , Cao Wenjun , Li Shengjie , Sun Xinghuai
Published: June 2022

Evidence suggests that ion metabolism may be associated with oxidative stress in the ocular tissue in glaucoma patients. This study is aimed at determining whether serum ion levels are associated with the onset and/or visual field (VF) progression of PACG. A total of 265 PACG and 166 healthy subjects were included in the cross-sectional study. Meanwhile, 265 subjects with PACG were followed up every six months for at least two years in the cohort study. All subjects were evaluated for serum concentrations of ions (calcium, phosphorus, potassium (K+), sodium, and chlorine) and underwent VF examination. Logistic regression analysis was performed to assess the risk factors for PACG. Cox regression analyses and Kaplan-Meier survival analyses were performed to identify factors associated with VF progression in PACG subjects. In the cross-sectional study, the K+ level (

4.31
±
0.39
 
mmol
/
L

) was significantly higher in the PACG group than in the normal group (

4.16
±
0.35
 
mmol
/
L

,

P
<
0.001

). Multiple logistic regression showed that the increased K+ level was a risk factor of PACG (

OR
=
2.94

,

95
%
CI
=
1.63
–
5.32

,

P
<
0.001

). In the cohort study, there were 105 PACG subjects with progression and 160 PACG subjects without progression. The progression group had significantly higher baseline serum K+ levels (

4.41
±
0.37
 
mmol
/
L

) than the no progression group (

4.25
±
0.39
 
mmol
/
L

) (

P
=
0.002

). The increased level of K+ at baseline was associated with faster VF progression (

HR
=
2.07

,

95
%
CI
=
1.23
–
3.46

,

P
=
0.006

). PACG subjects with higher baseline K+ levels had significantly lower VF nonprogression rates (51.94%) than subjects with lower K+ levels (68.38%, log-rank test

P
=
0.01

). This study found that increased serum K+ level is a risk factor of PACG and is associated with faster VF progression in PACG, which might result from its influence on the oxidative stress process.
SNHG5/miR-299-5p/ATF2 Axis as a Biomarker in Immune Microenvironment of Intervertebral Disc Degeneration
Authors: Shi Yu , Guo Rong , Zeng Yanyan , Fang Qian , Wang Xianglong , Liu Wei , Huang Guozhi , Wu Wen
Published: June 2022

Background and Objective. Intervertebral disc degeneration (IDD) is closely related to back pain. Finding biomarkers of IDD is very helpful for maintaining the function of the intervertebral disc and reducing the occurrence of back pain. This study is to explore the biomarkers in IDD and to explore the role of immune cell infiltration in IDD. Methods. The data sets of GSE56081 and GSE63492 in the Gene Expression Omnibus (GEO) database were used for screening and analysis, and the key gene markers were verified by GSE34095 and GSE126883. Finally, the infiltration of immune cells in the data were analyzed by MCPcounter analysis package. Results. In this study, a ceRNA containing 15 lncRNAs, 9 miRNAs, and 103 mRNAs was constructed. After multimodel screening and verification, key gene marker was found, namely, ATF2. The lncRNA/miRNA/mRNA axis closely related to ATF2 have also been found, namely, SNHG5/miR-299-5p/ATF2. In the analysis of immune infiltration, ATF2 was negatively correlated with T cells but positively correlated with neutrophils and endothelial cells. Conclusion. The SNHG5/miR-299-5p/ATF2 can be used as biomarker of IDD, and infiltration of immune cells plays an important role in the pathological development of IDD. In addition, as a marker of IDD, the involvement of the above-mentioned axis in the pathological development of IDD remains to be further explored.
[Retracted] Machine Learning Approach for Cardiovascular Risk and Coronary Artery Calcification Score
Authors: Aditya C. R. , Sattaru Naveen Chakravarthy , Gopal Kumaraguruparan , Rahul R. , Chandra Shekara G. , Nasif Omaima , Alharbi Sulaiman Ali , Raghavan S. S. , Jayadhas S. Arockia
Published: June 2022

Coronary artery calcification (CAC) could assist in the discovery of new risk elements for coronary artery disorder. CAC evaluation, on the other hand, is difficult due to the wide range of CAC in the populations. As a reason, evaluating and analysing data among research have become complicated. In the Research of Inherited Risk Factors for Coronary Atherosclerosis, we used CAC information to test the effects of different analytical methodologies on the correlation with recognized cardiovascular risk elements in asymptomatic patients. Cardiac computed tomography (CT) is also seeing an increase in examinations, and machine learning (ML) could assist with the growing amount of extracted data. Furthermore, there are other sectors in cardiac CT where machine learning could be crucial, including coronary calcium scoring, perfusion, and CT angiography. The establishment of risk evaluation algorithms based on information from CAC utilizing machine learning could assist in the categorization of patients undergoing cardiovascular into distinct risk groups and effectively adapt their treatments to their unique situations. Our findings imply that for forecasting CVD occurrences in asymptomatic people, age‐sex segmentation by CAC percentile rank is as effective as absolute CAC scoring. Longitudinal population‐based investigations are currently underway and would offer further definitive findings. While machine learning is a strong technology with a lot of possibilities, its implementations in the domain of cardiac CAC are generally in the early stages of development and are not currently commonly accessible in medical practise because of the requirement for substantial verification. Enhanced machine learning will, however, have a significant effect on cardiovascular and coronary artery calcification in the upcoming years.
Optimal Catheter Ablation Strategy for Patients with Persistent Atrial Fibrillation and Heart Failure: A Retrospective Study
Authors: Ma Cheng-ming , He Ye-jian , Li Wen-wen , Tang Hua-min , Dai Shi-yu , Yin Xiao-meng , Xiao Xian-jie , Xia Yun-long , Gao Lian-jun , Sun Yuan-jun , Wang Zhong-zhen , Zhang Rong-feng
Published: June 2022

The optimal catheter ablation (CA) strategy for patients with persistent atrial fibrillation (PeAF) and heart failure (HF) remains uncertain. Between 2016 and 2020, 118 consecutive patients with PeAF and HF who underwent the CA procedure in two centers were retrospectively evaluated and divided into the pulmonary vein isolation (PVI)-only and PVI + additional ablation groups. Transthoracic echocardiography (TTE) was performed at baseline, one month, and 12 months after the CA procedure. The HF symptoms and left ventricular ejection fraction (LVEF) improvements were analyzed. Fifty-six patients underwent PVI only, and 62 patients received PVI with additional ablation. Compared with the baseline, a significant improvement in the LVEF and left atrial diameter postablation was observed in all patients. No significant HF improvement was detected in the PVI + additional ablation group than in the PVI-only group (74.2% vs. 71.4%,

P
=
0.736

), but the procedure and ablation time were significantly longer (137.4 ± 7.5 vs. 123.1 ± 11.5 min,

P
=
0.001

). There was no significant difference in the change in TTE parameters and the number of rehospitalizations. For patients with PeAF and HF, CA appears to improve left ventricular function. Additional ablation does not improve outcomes and has a significantly longer procedure time. Trial registration number is as follows: ChiCTR2100053745 (Chinese Clinical Trial Registry; https://www.chictr.org.cn/index.aspx).
The Significance of PAX8‐PPARγ Expression in Thyroid Cancer and the Application of a PAX8‐PPARγ‐Targeted Ultrasound Contrast Agent in the Early Diagnosis of Thyroid Cancer
Authors: Fan Tianbing , Zhu Wenbo , Kong Min , Yang Xiaochan , Wang Cheng , Wang Min , Wang Zhaoyin
Published: June 2022

Objective. To investigate the significance of PAX8‐PPARγ expression in thyroid cancer and the application of a PAX8‐PPARγ‐targeted ultrasound contrast agent in the early diagnosis of thyroid cancer. Methods. In this study, the expression of PAX8‐PPARγ in thyroid cancer tissues, paracancer groups, and normal thyroid tissues was detected by western and immunohistochemical techniques; the effects of PAX8‐PPARγ expression inhibition on thyroid cancer cell growth, clonogenic ability, and antiapoptosis were examined. The terminal carboxylactic acid/hydroxyacetic acid copolymer (PLGA‐COOH) nanoparticles were prepared by the double emulsification solvent volatilization method. The in vitro cytotoxicity of the targeted contrast agent was detected by MTS and other methods; LD50 was used to evaluate its short‐term in vivo toxicity after intraperitoneal injection in mice. Results. PAX8‐PPARγ expression was significantly increased in thyroid cancer tissues, and the expression level of PAX8‐PPARγ was closely correlated with TNM staging and lymph node metastasis (P < 0.05). In addition, PAX8‐PPARγ was also expressed at high levels in thyroid cancer cell lines relative to normal thyroid cells. MTS experiments showed that the PAX8‐PPARγ‐targeted ultrasound nanocontrast agent had no significant toxic side effects on thyroid cells; countess observed that the contrast agent had no effect on cell survival and mortality; the LD50 assay showed that the targeted contrast agent had a wide safety range. Western blot showed the expression of caspase‐3, BAX, and Bcl‐2 in thyroid cancer cells, indicating that the nanocontrast agent has a good biosafety. In vitro targeting experiments showed that there were more nanospheres aggregated around the cells in the targeted contrast group. In vivo targeting imaging of nude mice revealed that the ultrasound signal was significantly enhanced in the targeted group compared with the nontargeted group after 20 min of LIFU irradiation. Conclusion. PAX8‐PPARγ overexpression in thyroid cancer cell lines and thyroid cancer tissues promoted the proliferation and antiapoptotic ability of thyroid cancer cells and promoted the tumorigenic ability in nude mice in vivo. We successfully prepared a PAX8‐PPARγ‐targeted ultrasound nanocontrast agent, which has regular morphology, uniform size, and high stability, and its liquid‐gas phase change can be promoted at lower temperature. Therefore, this contrast agent can achieve US‐targeted imaging and temperature phase transition function, and may have enhanced ultrasound imaging potential.
Construction and Analysis of Corporate Social Responsibility Report and Equity Capital Cost Algorithm Model Based on Intelligent Computing
Authors: Liu Jinglei , Sun Jinnan , Fang Minjian
Published: June 2022

In order to study the corporate social responsibility report and equity capital cost algorithm based on Intelligent Computing, this paper explores the relationship between social responsibility reports and the cost of equity capital based on the data of Chinese A-share listed companies from 2016 to 2020 using textual analysis and multiple statistical regression. The research results show that the publication of social responsibility reports by listed companies helps reduce the cost of equity capital and has a “first disclosure” effect; that is, the negative effect on the cost of equity capital tends to be more significant for companies that publish social responsibility reports for the first time; and the higher the quality of social responsibility reports, the more it helps companies to reduce their cost of equity capital.
Evaluation of Hydropower Generation and Reservoir Operation under Climate Change from Kesem Reservoir, Ethiopia
Authors: Mirani Kinfe Bereda , Ayele Mesfin Amaru , Lohani Tarun Kumar , Ukumo Tigistu Yisihak
Published: June 2022

Climate changes significantly cause the precipitation deficiency and in turn reduce the inflow amount in reservoir affecting hydroelectric power generation. The primary objective of this study was to evaluate hydropower generation and reservoir operation under climate change from Kesem reservoir. Recent Representative Pathway (RCP) scenarios were used to evaluate the impact of climate change on power generation. Power transformation equation and variance scaling approach were amalgamated to adjust the bias correction of precipitation and temperature, respectively. Bias, root mean square error, and coefficient of variation were used to check the accuracy of projected rainfall. The base and future precipitation, temperature, and evaporation trend was analysed using the Mann–Kendall test. The flow calibration and validation were carried out by the Hydrologic Engineering Center-Hydrologic Modelling System (HEC-HMS), and hydropower generation was evaluated with reservoir simulation model (MODSIM 8.1) under climate scenarios. The performance of the model was found good with Nash–Sutcliffe coefficient (NSE) of 0.72 and coefficient of determination (R2) of 0.73 for calibration and NSE of 0.74 and R2 of 0.75 for validation. Projected future climate scenarios predicted increasing and decreasing trend of temperature and precipitation, respectively. For RCP4.5 climate scenario, the average energy generation is likely to decrease by 0.64% and 0.82% in both short-term (2021–2050) and long-term (2051–2080), respectively. In case of RCP8.5 climate scenario, the average energy generation will be decreased by 1.06% and 1.35% for short-term and long-term, respectively. Remarkable reduction of energy generation was revealed in RCP8.5 with relation to RCP4.5 scenario. This indicates that there will be high energy fluctuation and decreasing trend in the future energy generation. The research finding is crucial for decision-makers, power authorities, governmental and nongovernmental organizations, and watershed management agencies to take care for sustainability in the future hydropower generation in the Kesem reservoir.
Brachialis Muscle Rupture in a Pediatric Patient Followed Up by Ultrasound Examinations: A Rare Case Report
Authors: Yamaji Akihiro , Uesugi Masafumi , Kamada Hiroshi , Ichimura Harumitsu , Yamazaki Masashi
Published: June 2022

Isolated brachial muscle injuries are relatively rare injuries and reportedly occur during forced elbow extension. Though commonly conservative treatment approach is adopted, the treatment criteria remain unclear. Here, we report the case of a patient who experienced functional recovery after conservative treatment for an isolated brachial muscle injury. The patient was an 8-year-old boy whose chief complaint was left elbow pain. The injury occurred when the patient fell while playing on gymnastics bars and bruised the palmar side of his left elbow on the bar. Owing to the pain in the left elbow, the patient came to our institution. There were no clear signs of deformities or swelling in the left elbow and no obvious tenderness. X-ray and computed tomography (CT) imaging examinations revealed no signs of a fracture or dislocation, and the patient was diagnosed with left brachialis muscle rupture based on magnetic resonance imaging (MRI). Although the brachialis muscle was complete ruptured, a healing tendency was seen on body surface ultrasound examinations over time, and the patient was treated conservatively. After 3 weeks of cast immobilization, the patient underwent range of motion exercises. Two months after the injury, there were no issues with elbow joint function in daily life activities and no limitations in range of motion. Here, MRI was used to diagnose brachialis muscle rupture, and ultrasound examinations were utilized to make treatment decisions.
An Investigation on the Activation Energy and Thermal Degradation of Biocomposites of Jute/Bagasse/Coir/Nano TiO2/Epoxy‐Reinforced Polyaramid Fibers
Authors: Fayaz H. , Karthik K. , Christiyan K. G. Jaya , Kumar M. Arun , Sivakumar A. , Kaliappan S. , Mohamed M. Jinnah Sheik , Subbiah Ram , Yishak Simon
Published: June 2022

Polyaramid is a type of aromatic polyamide that is used to strengthen materials due to its great thermal stability. The effect of adding 2 wt% of nano titanium oxide and 5% polyaramid fibers to an epoxy matrix composite reinforced with three distinct natural fibers (jute, bagasse, and coir fibers) on the structure and characteristics of the composite was examined in this study. Hand lay‐up approach was used to manufacture 40 wt. percent each fiber, separately reinforced biocomposites with the addition of polyaramid, and TGA experiments were used to investigate the thermal stability of jute/bagasse/coir composites with polyaramid. The thermal degradation of the polymer took place in five steps, according to the Broido plots, with the second step being the slowest and rate determining. Because less energy is used to remove hemicellulose and loosely binding water contained in bagasse fiber, Broido plots revealed that the first step heat degradation had the lowest activation energy (Ea).
Research on Students’ Satisfaction of Intelligent Learning Based on Text Mining Technology
Authors: Liu Wei , Zhang Yanqiu , Wang Tongtong
Published: June 2022

Recently, professionals have highlighted the need for students to have information technology and data analytic skills to be successful in the profession. To meet this demand, educators attempt to integrate technology into curricula. However, the satisfaction of students is of greater importance to evaluating curriculum quality than teaching. This study explores the perceptions that second-year undergraduate students (n = 51) enrolled in a Chinese University held about the teaching contents and teaching approaches of intelligent curriculum. Based on the data sample of the students’ summary text for curriculum learning, this study adopts TFIDF analysis, topic modeling, text sentiment analysis, and other text mining technologies so as to have a profound analysis on the students’ satisfaction. We find that: (1) the students have a higher satisfaction on the teaching contents involved in the financial sharing center compared to RPA financial robot; (2) students have a better adjustment to case analysis and flipped classroom compared to simulation training and classroom lecturing. Our findings and discussion should be of interest to leaders and teachers of business program seeking to integrate technology. We believe that this study’s results provide opportunities to have a further improvement of the teaching contents and optimization of teaching design to effectively improve the curriculum quality in order to achieve enhancement of students’ satisfaction.
Curcumin Plant for Colorectal Cancer Prediction and Prevention Using In Silico Molecular Analysis; HOT-MELT Extrusion
Authors: Muthu Mohamed Jamal Moideen , Kavitha Karuppaiyan , Ahmad Fazil , Sherbiny Mohamed El , Ebrahim Doaa , EL-Sagheer Aida M. , Ebrahim Hasnaa Ali , Abdelmonem Elsherbini Dalia Mahmoud , Ebrahim Abdelrahman Mosaab Abdella , Dejene Minilu
Published: June 2022

The impact of a soluble complex (SC) of curcumin (CuR) synthesized using hot melt (HM) and hot-melt extrusion (HE) technologies on adenocarcinoma cells for the treatment of colorectal cancer by enhancing CuR solubility is investigated in this work. In silico molecular modelling, solubility, drug release, and physicochemical analysis were all part of the phase solubility (PS) study, which featured a novel dyeing test and a central composite design to optimize the best complex (CDD). The optimal HE-SC (1 : 5) enhances solubility (0.8521 ± 0.016 mg·mL−1) and dissolution (91.87 ± 0.208% at 30 min), and it has an ideal stability constant (309 and 377 M−1) at 25 and 37°C and an AL type of isotherm, implying 1 : 1 stoichiometry according to the findings. An intermolecular hydrogen bond that has not undergone any chemical change and has resulted in the complete conversion of the amorphous form aids in the creation of SC. In vitro cytotoxicity was measured at IC50 on the SW480 (72 M·mL−1) and Caco-2 (40 M·mL−1) cells. According to apoptotic studies, apoptosis was responsible for the vast majority of cell death, with necrosis accounting for a small proportion of the total. In vivo toxicity was established using a zebrafish model, and a western blot examination revealed apoptosis at the molecular level. It was argued that the novel formulations developed using HE technology are more significant and effective than existing pure CuR formulations.
Application of Big Data in Evaluation of Agricultural Products E-Commerce under the Background of Rural Revitalization
Authors: Sun Jinli
Published: June 2022

The development of agricultural products e-commerce (APEC) plays an important role in the smooth progress of the rural revitalization strategy. This paper constructs the evaluation index system of the development level of APEC through literature induction, including rural residents, infrastructure conditions, policy support, the quality of APEC platform, operation effect, and social effect. Then, we use the analytic hierarchy process (AHP) to calculate the index weight and take Shanxi Province of China as the research object to evaluate and analyze the development level of APEC. The evaluation results show that the overall development of APEC in Shanxi Province is at a general level. Finally, we put forward some suggestions for the development of APEC, such as improving the standardization system of APEC.
Associations of the Cardiometabolic Index with the Risk of Cardiovascular Disease in Patients with Hypertension and Obstructive Sleep Apnea: Results of a Longitudinal Cohort Study
Authors: Cai Xintian , Hu Junli , Wen Wen , Wang Jingyu , Wang Mengru , Liu Shasha , Zhu Qing , Hong Jing , Dang Yujie , Yao Xiaoguang , Sun Le , Zhang Delian , Luo Qin , Li Nanfang
Published: June 2022

Purpose. We aimed to explore the relationship between the cardiometabolic index (CMI) and cardiovascular disease (CVD) and its subtypes (coronary artery disease and stroke) in patients with hypertension and obstructive sleep apnea (OSA). Methods. We conducted a retrospective cohort study enrolling 2067 participants from the Urumqi Research on Sleep Apnea and Hypertension study. The CMI was calculated as triglyceride to

high
‐
density
 
lipoprotein
 
cholesterol
 
ratio
×
waist
‐
to
‐
height
 
ratio

. Participants were divided into three groups (T1, T2, and T3) according to the tertile of CMI. The Kaplan-Meier method helped to calculate the cumulative incidence of CVD in different groups. We assessed the association of CMI with the risk of CVD and CVD subtypes by estimating hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox models. Results. During a median follow-up of 6.83 years (interquartile range: 5.92-8.00 years), 326 incident CVD were identified, including 121 incident stroke and 205 incident coronary heart disease (CHD). Overall, after adjusting for confounding variables, CMI was positively associated with the risk of new-onset CVD (per SD increment, adjusted HR: 1.31; 95% CI: 1.20, 1.43), new-onset CHD (per SD increment, adjusted HR: 1.33; 95% CI: 1.20, 1.48), and new-onset stroke (per SD increment, adjusted HR: 1.27; 95% CI: 1.10, 1.47). Similar results were obtained in various subgroup and sensitivity analyses. Adding CMI to the baseline risk model for CVD improved the

C

-index (

P
<
0.001

), continuous net reclassification improvement (

P
<
0.001

), and integrated discrimination index (

P
<
0.001

). Similar results were observed for CHD and stroke. Conclusion. There was a positive association between CMI levels and the risk of new-onset CVD in patients with hypertension and OSA. This finding suggests that CMI may help identify people at high risk of developing CVD.
The Clinical Efficacy of Cedilanid and Isosorbide Dinitrate plus Pericardial Dissection for Chronic Constrictive Pericarditis in the Elderly and Its Influence on Plasma Endothelin, Atrial Natriuretic Peptide, and Systemic Immune-Inflammation Index
Authors: Shao Yan , Yang Zhirong , Yin Lu , Wang Qiang , Wang Jie
Published: June 2022

Objective. To investigate the clinical efficacy of cedilanid and isosorbide dinitrate plus pericardial dissection for chronic constrictive pericarditis in the elderly. Methods. Ninety elderly patients with chronic constrictive pericarditis admitted to our hospital from March 2018 to October 2020 were recruited and assigned to receive either cedilanid and isosorbide dinitrate (control group A), pericardial dissection (control group B), or cedilanid and isosorbide dinitrate plus pericardial dissection (combination group) via random number table method, with 30 patients in each group. Outcome measures included plasma endothelin, atrial natriuretic peptide, system immune-inflammation indices, treatment effect, quality of life, mental state, and treatment satisfaction. Results. The combination group had significantly higher treatment satisfaction and treatment efficacy than control groups A and B (

P
>
0.05

). The combination group showed the lowest levels of atrial natriuretic peptide and endothelin, followed by control group A, and group B (

P
<
0.001

). The combined therapy resulted in significantly lower levels of system immunity index, lower Hospital Anxiety and Depression Scale (HAD) scores, and better General Quality of Life Inventory-74 (GQOLI-74) scores than those of the control group B, followed by group A (

P
<
0.001

). Conclusion. Cedilanid and isosorbide dinitrate plus pericardial dissection for elderly patients with chronic constrictive pericarditis enhances the level of plasma endothelin, atrial natriuretic peptide, and systemic immune-inflammation indexes of patients and improves their quality of life, which shows great potential for clinical promotion.
Part Classification Prediction Based on Convolutional Neural Network
Authors: Zhang Minhao
Published: June 2022

Mechanical parts are an important part of the machinery industry. However, the current automated production lines for mechanical parts face great challenges. Different types and sizes of parts make automatic segmentation of parts on industrial lines prone to wrong segmentation. Therefore, this paper proposes a part classification method based on a convolutional neural network. The method can utilize a large amount of data of mechanical parts and then analyze and learn from the data through convolutional neural networks to detect and classify parts more accurately. It can effectively solve the problems of high-cost and error-prone manual parts classification and greatly reduce the cost of automatic detection and classification of enterprises. We adopt this model to conduct a series of experiments on the Pacon dataset. It includes the calculation of weights and the construction of confusion matrix values. The experimental results show that the model achieves excellent performance in parts classification and prediction.
Prevalence of Keratoconus in a Population-Based Study in Syria
Authors: Salman Abdelrahman , Darwish Taym , Ghabra Marwan , Kailani Obeda , Haddeh Yusra , Askar Mohammad , Ali Ammar , Ali Ali , Alhassan Sara
Published: June 2022

Aim. To determine the prevalence and associations of keratoconus (KC) in a university student population in Syria. Methods. A prospective multicentre cross-sectional cohort study was conducted at two universities in Syria. Student volunteers were recruited from Tishreen University (Latakia governorate) and Damascus University (Damascus governorate). All participants underwent a comprehensive ocular examination. Placido/Scheimpflug-based corneal imaging using the Sirius (CSO, Florence. Italy), and a questionnaire to evaluate the baseline characteristics and medical history, as well as to highlight possible risk factors of KC. Univariate and bivariate analyses were performed. Results. The estimated prevalence of KC among all subjects was 1.43% (n = 12). A strong association between eye rubbing and keratoconus was found (OR 9.33, 95% CI 2.94–29.63,

P
<
0.001

). Damascus University participants had a higher prevalence of KC than Tishreen University. However, the difference was not statistically significant. Conclusion. The prevalence of keratoconus in this Syrian student population was 1.43%. The results of this study demonstrate a high prevalence of keratoconus in the study population. Early detection of keratoconus through screening may yield benefits in preventing devastating sequelae of KC in populations with a high prevalence.
First Case Report of Arrhythmogenic Right Ventricular Cardiomyopathy Showing Refractory Ventricular Tachycardia Induced by Thyroid Storm due to Graves’ Disease
Authors: Matsubara Masaki , Tanaka Tomohiro , Wakamiya Akinori , Tamanaha Tamiko , Makino Hisashi , Tanei Tomonori , Aiba Takeshi , Kusano Kengo , Hosoda Kiminori
Published: June 2022

A 48-year-old man who was diagnosed with arrhythmogenic right ventricular cardiomyopathy (ARVC) due to a plakophilin 2 gene mutation developed acute both-sided heart failure with rapid atrial fibrillation and was hospitalized. After admission, sustained ventricular tachycardia, which was refractory to antiarrhythmic agents, occurred repeatedly, and required electrical cardioversion. He was diagnosed with thyroid storm due to Graves’ disease, and treatment for hyperthyroidism was initiated. After the treatment, lethal arrhythmia did not reoccur, and biventricular heart failure ameliorated. To our best knowledge, this is the first report in English of a patient with ARVC showing refractory arrhythmia induced by thyroid storm due to Graves’ disease.
Roof-Breaking Characteristics and Ground Pressure Behavior in Deep Jurassic Coal Seams: A Thick-Plate Model and Field Measurements
Authors: Zhang Wei , Zhang Yandong , Zhang Weisheng , Chen Liang , Li Fanjia , Xie Kaidi
Published: June 2022

Roof-breaking characteristics and ground pressure behavior of the coalface are instrumental in guiding deep Jurassic coal seam mining, in particular in the Shaanxi and Inner Mongolia regions of China. A thick-plate mechanical model (TPMM) of the main roof was developed and applied to the case study of 21102 first-mined coalface (FMC) of the Hulusu Coal Mine (HCM) in the Hujirt Mining Area (HMA), China. A theoretical analysis performed via the developed model revealed that the first and periodic breaking intervals of the main roof were 40.6 and 25.0 m, respectively. The roof failure occurred in the tensile mode, was controlled by the internal stress

σ

x

in the rock strata, and started from the center of the long side with the fixed support in the goaf. The field measurement of roof weighting was also performed for the coalface advance from zero to 400 m. The measurement results showed that the first weighting average interval was 41.4 m, and the average interval of periodic weighting was 22.0 m, which agreed with the theoretical calculation and proved the proposed model’s feasibility. Finally, the frequency distribution features of the hydraulic support working resistance in the FMC were analyzed statistically. The results showed that the ZY10000-16/32D supports could adapt to the mining geological conditions of the FMC. However, the margin of the rated working resistance of supports was still small. Thus, roof management enhancement during the mining process was strongly recommended. These research findings could offer theoretical guidance for safe and high-efficiency production in the coal mines under similar geological conditions.
Automated Screening of COVID‐19‐Based Tongue Image on Chinese Medicine
Authors: Zhang Guang , He Xueying , Li Delin , Tian Cuihuan , Wei Benzheng
Published: June 2022

Objective. Artificial intelligence‐powered screening systems of coronavirus disease 2019 (COVID‐19) are urgently demanding since the ongoing outbreak of SARS‐CoV‐2 worldwide. Chest CT or X‐ray is not sufficient to support the large‐scale screening of COVID‐19 because mildly‐infected patients do not have imaging features on these images. Therefore, it is imperative to exploit supplementary medical imaging strategies. Traditional Chinese medicine has played an essential role in the fight against COVID‐19. Methods. In this paper, we conduct two kinds of verification experiments based on a newly‐collected multi‐modality dataset, which consists of three types of modalities: tongue images, chest CT scans, and X‐ray images. First, we study a binary classification experiment on tongue images to verify the discriminative ability between COVID‐19 and non‐COVID‐19. Second, we design extensive multimodality experiments to validate whether introducing tongue image can improve the screening accuracy of COVID‐19 based on chest CT or X‐ray images. Results. Tongue image screening of COVID‐19 showed that the accuracy (ACC), sensitivity (SEN), specificity (SPEC), and Matthew correlation coefficient (MCC) of the improved AlexNet and Googlenet both reached 98.39%, 98.97%, 96.67%, and 99.11%. The fusion of chest CT and tongue images used a tandem multimodal classifier fusion strategy to achieve optimal classification, and the results and screening accuracy of COVID‐19 reached 98.98%, resulting in a significant improvement of 4.75% the highest accuracy in 375 years compared with the single‐modality model. The fusion of chest x‐rays and tongue images also had good classification accuracy. Conclusions. Both experimental results demonstrate that tongue image not only has an excellent discriminative ability for screening COVID‐19 but also can improve the screening accuracy based on chest CT or X‐rays. To the best of our knowledge, it is the first work that verifies the effectiveness of tongue image on screening COVID‐19. This paper provides a new perspective and a novel solution that contributes to large‐scale screening toward fast stopping the pandemic of COVID‐19.
Compatibility of Niuhuang Jiedu Tablets Results in Attenuated Arsenic Bioaccumulation and Consequent Protection against Realgar-Induced Toxicity in Mice
Authors: Xu Wenfeng , Xu Shuo , Kuang Yongmei , He Xiaorong , Jin Pengfei
Published: June 2022

Niuhuang Jiedu Tablets (NJT) is a popular over-the-counter traditional Chinese medicine (TCM) preparation. It is composed of realgar (As2S2) and seven other TCMs. The safety of NJT is of growing concern because arsenic (As) is carcinogenic to humans. The toxicity of realgar in vivo can mainly be attributed to the absorbed and accumulated As. This study investigated the correlation between the detoxification effects of the other TCMs in NJT on realgar and their influences on arsenic accumulation of realgar in mice. Histopathological examination, clinical biochemical test, and metabolic profiling analysis were used to evaluate the toxicity of realgar. The concentration of arsenic in mice whole blood as the hazard indicator was determined by inductively coupled plasma mass spectrometry (ICP-MS). The compatibility of NJT could decrease arsenic bioaccumulation of realgar in mice whole blood and consequently reduce the toxicity of realgar, which could be considered as one detoxification mechanism to realgar in NJT. The combination of Rhei Radix et Rhizoma, Scutellariae Radix, Platycodonis Radix, and Glycyrrhizae Radix et Rhizoma exhibited almost the same effects as NJT in regulating the serum biochemical parameters and metabolic profiles disturbed by realgar and in reducing arsenic accumulation of realgar in mice whole blood.
Hydrodynamic Boundary Layer Flow of Chemically Reactive Fluid over Exponentially Stretching Vertical Surface with Transverse Magnetic Field in Unsteady Porous Medium
Authors: Sulemana M. , Seini I. Y. , Makinde O. D.
Published: June 2022

This article addresses the hydrodynamic boundary layer flow of a chemically reactive fluid over an exponentially stretching vertical surface with transverse magnetic field in an unsteady porous medium. The flow problem is modelled as time depended dimensional partial differential equations which are transformed to dimensionless equations and solved by means of approximate analytic method. The results are illustrated graphically and numerically and compared with previously published results which shown a good agreement. Physically increasing Eckert number of a fluid amplifies the kinetic energy of the fluid, and as a novelty, the Eckert number under the influence of chemically reactive magnetic field is effective in controlling the kinematics of hydrodynamic boundary layer flow in porous medium. Interestingly, whilst the Eckert number amplifies the thermal boundary layer thickness and velocity as well as the concentration of the fluid, the presence of the magnetic field and the strength of the chemical reaction have a retarding effect on the flow. Also, the chemical reaction parameter and permeability of porous medium are effective in reducing skin friction in chemically reactive magnetic porous medium and are relevant in practice because reduced skin friction enhances the efficiency of a system. The results of the current study are useful in solar energy collector systems and materials processing.
[Retracted] Study on Ultrasonographic Diagnosis and Postoperative Comprehensive Nursing of Rectal Cancer in Preoperative Staging
Authors: Gao Jie , Wang Hui , Wang Zhihui
Published: June 2022

The aim of this study is to evaluate the value of ultrasonography in preoperative T staging of rectal cancer and to study the effect of psychological nursing and colostomy nursing in patients with rectal cancer after colostomy. In this study, a retrospective comparative analysis was conducted on 41 patients with colostomy after rectal cancer surgery who had been treated in a hospital from June 2020 to June 2021 and 41 patients who only had general nursing. By analysis, 42 cases were detected by TRUS. Ultrasonic stage (uT) was consistent with pathological stage (pT) in 32 cases, and the coincidence rate was 76%. The tumor length and short diameter measured by 0RUS were not significantly related to pT (P = 0.083, 0.499), while the invasion diameter was related to pT (P = 0.015). The scores of SAS and SDS in the nursing group were significantly lower than those in the conventional group, and the degree of depression and anxiety in the nursing group was significantly improved (P < 0.05). The quality‐of‐life score in the nursing group was significantly higher than that in the conventional group (P < 0.05), and the daily living ability, regular defecation, and self‐care ability of ostomy in the nursing group were significantly improved. The nursing satisfaction of patients in the nursing group was 95.12%, while that in the conventional group was 80.49%. The nursing satisfaction of patients in the experimental group was significantly higher than that in the conventional group (P < 0.05). Therefore, for most patients with rectal cancer, TRUS is an effective means of T staging. When it is difficult to determine the depth of tumor invasion, combining the invasion circumference can improve the accuracy of staging. Conventional nursing combined with psychological nursing and colostomy nursing for patients with rectal cancer after colostomy can effectively relieve patients' bad emotions, improve patients' self‐care ability, and satisfaction degree toward nursing and application of nursing is high.
[Retracted] lncRNA FOXD2‐AS1 Promotes the Retinoblastoma Cell Viability and Migration by Sponging miR‐31
Authors: Liang Yan , Wang Hong , Song Ruiying , Yin Xiuyan
Published: June 2022

Background. The purpose of this study was to explore the functions of FOXD2‐AS1 and miR‐31 in retinoblastoma. Material and Methods. An RT‐qPCR assay was applied to calculate the mRNA levels of FOXD2‐AS1, miR‐31, and PAX9. A dual‐luciferase reporter gene assay was employed to verify the connection between FOXD2‐AS1, miR‐31, and PAX9 expression. Results. FOXD2‐AS1 was upregulated, and miR‐31 was lowly expressed in retinoblastoma. Low expression of FOXD2‐AS1 promoted cell proliferation and migration, and upregulation of FOXD2‐AS1 inhibited proliferative and migratory abilities. lncRNA FOXD2‐AS1 directly bound to miR‐31 and regulated miR‐31 expression in SO‐RB50 cells. Cell proliferation and migration were inhibited by the miR‐31 mimic. miR‐31 mediated PAX9 expression via directly binding to PAX9 mRNA. A miR‐31 inhibitor partially reversed the effect of FOXD2‐AS1 knockdown on the proliferation and migration in SO‐RB50 cells. FOXD2‐AS1 knockdown reduced PAX9 expression in SO‐RB50 cells. PAX9 had negative connection with miR‐31, and it had positive relationship with FOXD2‐AS1. Conclusion. lncRNA FOXD2‐AS1 inhibited cell proliferation and migration via the miRNA‐31/PAX9 axis in retinoblastoma.
Design of Comprehensive Evaluation System for College Sports Flipped Classroom Using AHP-fuzzy Matrix
Authors: Zhao Meng
Published: June 2022

With the advancement of information technology, academics have steadily strengthened their research and creation of a complete assessment system for college sports flipped classrooms, so as to improve school education quality. Teachers can use classroom evaluations to quickly identify the flaws in their own teaching approaches and switch to a more effective teaching mode. The old paper assessment approach, on the other hand, is inefficient, which wastes time and money. This paper will look at how to use an AHP-fuzzy matrix to create a thorough assessment system for college athletics flipped classrooms. The main algorithm of the AHP-fuzzy matrix is proposed in this work, as well as the fuzzy comprehensive evaluation approach. The stability and operating efficiency of the system are constantly rising. Stability rose from 77% in the first experiment to 85% in the 10th experiment, an 8% increase. The operating efficiency has risen from 85% at the beginning to 87%. Although the rise is not large, it has been stable. This also shows that the system designed in this paper not only has strong stability but also has high operating efficiency.
Evaluation of Association of Oral Bacterial Profile with HBV and HCV Infection and T Lymphocyte Level in HIV-Positive Patients
Authors: Lavaee Fatemeh , Modarresi Farzan , Amookhteh Samira , Amiri Mohammad Amin
Published: June 2022

Background. This study was aimed to determine the oral bacterial profile of HIV-positive patients and their correlation with T lymphocyte and CD4 count and hepatitis B and C incidence. Methods. In this study, 73 patients who were diagnosed HIV-positive and were referred to Shiraz HIV research center for routine dental treatment were enrolled. Demographic data including sex, ethnicity, CD4+ T cell, and T lymphocyte counts were collected from their medical records. Supragingival dental plaque and samples from the dorsal of the tongue were collected by sterile swabs. These samples were transferred to the microbiology laboratory of Jahrom University of Medical Sciences. After primary biochemical test of cultured samples, assessment of bacterial biofilms was done by DNA extraction. Real-time PCR with specific primer of each bacterial species was done, and assessment of the results of real time PCR led to determination of the species of the evaluated bacteria. The correlation of bacterial prevalence with hepatitis B and C was evaluated by chi-square test. Furthermore, Mann–Whitney test was used to evaluate the association of bacterial species prevalence with CD4 and T lymphocyte level. Results. The prevalence of none of the detected bacteria had statistically significant relationship with hepatitis C, except for Peptostreptococcaceae (

p

value = 0.016) in the tongue plaque and Leptotrichia (

p

value = 0.022) in dental plaque. None of the evaluated bacteria showed any significant association with CD4 and T lymphocytes level, except for Kingella (

p

value = 0.025, 0.019, respectively), and also no significant correlation was reported with CD4, except for Gemella (

p

value = 0.021) and Campylobacter gracilis (

p

value = 0.029). Conclusions. The diversity of the detected bacteria was more in dental plaque, while their density was more noticeable in the tongue plaque. No significant correlation was found between the prevalence of most of the detected bacteria and CD4 level and T lymphocyte level and incidence of hepatitis B and C.
Microscope Usability Evaluation Based on Fuzzy Analytic Hierarchy Process
Authors: Chen Chaojie , Zheng Kangjie , Wang Yishuai , Li Jiangyu , Liu Xiaojiao , Zheng XiaoHan , Yu Yu
Published: June 2022

The basic position of microscope in experimental teaching is increasingly prominent, but there is still a big gap between its multidimensional index factors such as operation efficiency, effectiveness, and user satisfaction and the goal of teaching application. Based on the usability design theory, Kinovea video analysis software and ANSYS finite element analysis software were separately used to carry out user observation and product structure testing and analyze the multiple heterogeneous factors affecting the use of microscopes in teaching application scenarios and record usability data; the Fuzzy Analytic Hierarchy Process was utilized to summarize and analyze the usability data and construct a usability evaluation model of microscope. Under the guidance of the usability evaluation model, the microscope was optimized, and its usability was verified by Jack simulation and finite element analysis at last. The results show that: On the layer of operational efficiency, the usability index of intuitive operation and easy to learn of the microscope accounts for the largest weight. On the layer of effectiveness, the index of stable structural connection of the microscope has a larger weight; adjusting the material properties and product structure can effectively improve the stability of the microscope. On the layer of user satisfaction, the index of use comfortably of the microscope accounts for the largest weight, and the comfort of students’ neck and other joints can be improved by optimizing the microscope’s functional layout. This research provides an evaluation index reference and design optimization experience for the multiple heterogeneous factor-driven microscope usability design in teaching applications.