bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental investigation of FRP strengthened reinforced concrete T-beams in torsion
Authors: Constantinos Β. Demakos  , Constantinos C. Repapis  , Dimitrios P. Drivas  , Panagiotis Kaoukis
Published: July 2023

In general, reinforced concrete (RC) members are most commonly influenced by flexural moments, axial and shear forces. However, they may also be subject to torsional moments. Torsion in reinforced concrete (RC) beams is an important phenomenon that affects the structural behaviour of buildings. Both the concrete and steel reinforcement contribute to the torsional resistance of a RC member. However, the contribution of concrete is usually neglected by the modern design codes, due to cracking. Moreover, the subject of maintenance and repair or strengthening of existing RC structures is a significant problem. The last years, fibre reinforced polymer (FRP) is widely used as external reinforcement in flexural and shear strengthening. Nevertheless, its use in torsional strengthening is not so widely investigated. Ιn this paper, the torsional behaviour of RC T-beams reinforced in shear with FRPs is experimentally investigated. Five groups of T-beams subject to pure torsion, two of which are control beams and other three beams are strengthened in shear with U-jacketed FRP fabrics. Experimental results reveal that FRPs can increase the ultimate torsional capacity of the member.
Nephroprotective effect of Pterocarpus mildbraedii leaf extract in paracetamol-induced toxicity in Wistar rats: A histopathological investigation
Authors: Elisha Urom  , Saviour God’swealth Usin
Published: July 2023

Pterocarpus mildbraedii leaf is among the most commonly consumed leafy vegetables in west African sub-region. In South-East and South-South geopolitical zones of Nigeria, it is used for treatment of various health disorder such as headaches, pains, fever, convulsions, and respiratory disorders. This study was aimed at evaluating the possible effect of ethanol leaf extract of Pterocarpus mildbraedii on paracetamol-induced nephrotoxicity in Wistar rats. Twenty (20) Wistar rats weighing between 190 – 240 g were used for this study and divided into five (5) groups, each group having four (4) animals, described as follows; Group A was given distilled water only (positive control). Group B was given 700 mg/kg paracetamol with no treatment (negative control); Group C was given 700 mg/kg paracetamol and treated with 60 mg/kg of plant extract. Group D was given 700 mg/kg paracetamol and treated with 30 mg/kg of plant extract. Group E given 700 mg/kg of paracetamol and treated with 15 mg/kg of plant extract. At the end of the four (4) weeks of treatment, the kidneys were removed, weighed and sacrificed for histological examinations. Coronal sections of the kidney tissues were immersion fixed in 10 % PBS-buffered formalin and embedded in paraffin. The results obtained revealed a normal cellular architecture in the groups treated with the leaf extract. Conclusively, the result suggests protective effects of ethanol extract of P. mildbraedii leaf on the paracetamol-induced toxicity on the kidney cells.
Surgical approach to evaluate neck mass in children concerning management protocols
Authors: Chowdhury NH  , Islam MA  , Mohammad T  , Khan SR
Published: July 2023

Background: Neck masses in children are not common presentations in Head-neck specialized practice but when present they createpotential diagnostic dilemmas for consulting surgeon. These children may present as havingapparently simple harmless mass in the neckbut there are several alarming diagnostic possibilities. Attending surgeons should concern about the wide range ofdifferential diagnoses. Objective: Differential diagnosis and management of Neck masses in children differ from those in adults. A systematic approach to diseases and judicious investigation protocol is crucial to ensure appropriate assessment and management. This prospective study was undertaken to assessmanagementprotocol for the evaluation process of neck mass in case of children. Methods:This is a prospective study of 6 yearsin the tertiary hospital based in Dhaka between 2016 and 2022. 385 (131, girls, 254 boys) patients aged between 2 years to 14 years were reviewed. The history, physical examination findings, imaging reports (USG, color Doppler, CT, and MRI)FNAC, and the histopathology report are taken into consideration as managementprotocol for the evaluation process. Results: In this studyauthors observed congenital masses were most commonly found in this age group, followed by Infectious and neoplastic masses, at a rate of 57.40%, 27.53%, and 15.06% respectively. Thyroglossal Cyst constituted 33.48% of congenital masses. Non-Hodgkin lymphoma was the most frequent type of malignancy (50%). The lateral neck was the most affected site (47.01%). Conclusion: The diagnosis can be reached with a brief history and prompt physical examination. Ultrasound and Color duplex study should be the first choice for evaluation. Fine needle aspiration cytology followed by excisional biopsyfind out the tissue of origin. FNAC can guide the surgeon initially to reach the disease and give the clue for the next steps on evaluation. CT SCAN & MRI should be avoided if not clearly indicated as both need sedation in case of children and CT emits radiation effect.
Augmented reality in teaching and learning English as a foreign language: A systematic review and meta-analysis
Authors: Yousif Alshumaimeri  , Noman Mazher
Published: July 2023

This study provides implications on the application of augmented reality (AR) in education through a review of research papers focused on a type of XR technology, identifying and describing its practical application using examples drawn from different contexts in facilitating learning English as a foreign language (EFL). Specifically, we conducted a systematic review and meta-analysis to bring together information on how available tools employing XR technology can be used to enhance English language learning. This study focuses on providing information for a better understanding of AR-based learning and its integration in both classroom and personal customized learning of EFL. The review aligns with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Statement (PRISMA) guidelines. Literature was searched from ACM Digital Library, IEEE Xplore, PubMed, ERIC, the Cochrane CENTRAL library, and Google Scholar. The studies reviewed identified three major AR game-based strategies used in language learning: augmented word spelling games, card-based word visualization activities, and word annotations or word spelling games. The meta-analysis yielded a random effect size of 8.46 [−1.93, 18.85] at a 95% confidence interval but found no significant effect (z = 1.60 (p = 0.11)). An AR system can effectively teach students of all ages since it enhances engagement in learning. Additional research is necessary to further inform learners and trainers on the full extent of the implementation of AR technology in learning.
Pulmonary and cerebral leukostasis as an unusual case in a patient with chronic leukemia in chronic phase: Case report and literature review
Authors: Diana Margarita Otero de la Hoz  , Wilver Arley Mosquera Vanegas  , Laura Isabel Acosta Galíndez  , Ismael Arango Herrera  , Juan Luis Echeverri Ospina
Published: July 2023

Hyperleukocytosis is defined as an absolute white blood cells count greater than 100.000cel/ml, being more common in acute myeloid leukemia (AML) than in chronic myeloid leukemia (CML). CML is the predominance of mature granulocytes, its main manifestation is hyperleukocytosis, that can increase the risk of pulmonary and cerebral leukostasis; although this event is uncommon in patients with CML in chronic phase. We present the case of a 38-year old male who presents with hyperleukocytosis that progress to hypoxemic respiratory failure and multiple intracerebral hemorrhage, treated with cytoreduction and tyrosine kinase inhibitors; without leukapheresis, with appropriate clinical evolution. Leukostasis is a high mortality complication that should be considered in patients with hyperleukocytosis who presents with neurological or respiratory distress, and constitutes a medical emergency in which treatment can’t be delayed.
Breast cancer in women: Its risk factors and prevention
Authors: Prachi Mishra  , Saloni Mishra  , Krishna Kumar Prajapati
Published: July 2023

Breast cancer occurs when some breast cells begin to grow abnormally than healthy cells do and continue to accumulate, forming a lump or mass. The tumor size, lymph node status, histological grade, mitotic index, presence of estrogen and progesterone receptors, c-erbB2 expression, p53 and the MIB-1 proliferation index were evaluated histo-pathologically and immunohistochemically in the breast cancer patients. Types of chemicals carcinogens such as benzene, asbestos, nickel, cadmium, vinyl chloride, asbestos, N-nitrosamines, tobacco or cigarette smoke (contains at least 66 known potential carcinogenic chemicals and toxins), asbestos, and aflatoxin etc. play important role to induce breast cancer. Bovine leukemia virus (BLV) infects dairy and beef cattle's blood cells and mammary tissue. The most well-known are breast cancer gene 1 (BRCA1) and breast cancer gene 2 (BRCA2), both of which significantly increase the risk of both breast and ovarian cancer. The tamoxifen and aromatase inhibitors express the estrogen receptor (ER) and/or progesterone receptor (PR) are likely to respond to endocrine (hormone) therapies. Where resources are limited, diagnosis and treatment services should initially target all patients presenting with curable cancers, such as breast, cervical and oral cancers that can be detected early.
Investigation of the Effects of Rutin on Valproic Acid Induced Testicular Damage in Rats
Authors: AKARSU Serkan Ali , KANKILIÇ Nâzım Abdülkadir , ERDOĞAN Ender
Published: July 2023

Valproic acid (VALP) is a drug used for many psychiatric diseases such as epilepsy. However, the use of VALP has potential side effects on various tissues, including the testicles. Rutin (RUT) is a flavonoid with protective effects against oxidative stress-induced diseases and lipid peroxidation. In this study, the protective effects of RUT against testicular damage caused by VALP were investigated. For this purpose, 35 male Spraque-Dawley rats weighing 220-250 g were used in the study. The rats were randomly divided into 5 groups as Control (physiological saline), RUT (100 mg/kg/bw), VALP, (500mg/kg/bw), VALP+RUT 50 (500 mg/kg/bw VALP+50 mg/kg/bw RUT), and VALP +RUT 100 (500 mg/kg/bw VALP+100 mg/kg/bw RUT). At the end of the RUT and VALP administrations, the rats were sacrificed and testicular tissues were taken to be used for biochemical and spermatological analyzes. According to the results of this study, the MDA level in the testicular tissues of the VALP group was found to be statistically higher than the other experimental groups (p
PROGRAM LITERASI KESEHATAN GIGI DAN MULUT MELALUI KUIS INTERAKTIF TENTANG KEGOYANGAN GIGI PADA MASYARAKAT DI WILAYAH KERJA PUSKESMAS MARGASARI, TEGAL
Authors: Poetri Adisty Restu , Novianti Shella Indri , Mayangsari Regilia Shinta , Yuniar Savira Nurazky , Indrawati Silvia Vera , Dimas P.P Muhammad
Published: July 2023

Background: Oral health is an important part of an individual's overall health. The presence of disorders of the oral cavity can significantly affect a person's life. One of the problems that often arise is loose teeth. Loose teeth can be caused by disease or injury to the gums and the supporting tissues of the teeth. The most common factor that causes loose teeth is the buildup of plaque or tartar. This condition can cause damage to the bone that supports the teeth and the periodontal ligament which causes the teeth to become loose. In addition, a person's systemic conditions such as diabetes mellitus also

aggravate the condition of tooth mobility. Method: This community service is carried out by counseling, distributing leaflets, poster, quiz, and giving door prizes. The audience's level of knowledge related to dental and oral health, especially periodontal tissue was evaluated using a questionnaire Result: 1 respondent (3.33%) had low oral hygiene habits, 24 respondents (83.3%) had moderate oral hygiene habits, and 4 respondents (13.3%) had very good/high oral hygiene habits. Conclusion: Dental and oral health education in the community can effectively improve oral hygiene
METHOD OF ACTIVE EDUCATION THROUGH THE GAJE PROGRAM (GAMES TMJ) AS AN EFFORT TO IMPROVE KNOWLEDGE OF THE MARGASARI COMMUNITY RELATED TO JAW JOINT DISORDERS
Authors: Hutami Islamy Rahma , Rahadian Arief , Mayangsari Regilia Shinta , Nurazky Savira , Indrawati Silvia Vera
Published: July 2023

Background: This TMJ problem or jaw joint disorder is classified as an emergency, so treatment must be done immediately. The causes of this jaw joint problem are multifactorial. Generally divided into two, namely structural disorders and functional disorders. Functional disorders arise due to deviant function due to abnormalities in the position or function of the teeth and chewing muscles. Treatment, when someone has TMJ problems, is usually a reduction action that is carried out directly by a doctor. This cannot be done by ordinary people. However, sometimes people self-diagnose and resort to invalid sources which can actually lead to more serious problems. Method: The educational method is carried out by active counseling and discussions given to the people of Margasari Village. Then, the community was asked to fill out a questionnaire to assess the effectiveness of delivering material about this TMJ. Result: People who have filled out the questionnaire were found to have a significant difference between before and after being given the material. People become more aware of the material and are expected to be able to apply it in everyday life. Conclusion: There is a significant difference between before and after being given TMJ games.
UK Universities Face their Toughest Test
Authors: Jack Andrew
Published: July 2023

The School of Oriental and African Studies seemed a symbol of stability when it celebrated its centenary in 2016 by taking over and renovating the University of London’s imposing Senate House building in central London. It was a bold move to lure the best students. But just three years later its future has become much shakier, with its undergraduate intake down 40 percent and a £7m operating deficit. “The competition is brutal,” says Professor Stephen Hopgood, Soas’s international pro-director. “We are small and specialist, and if undergraduate fees are cut, it’s going to be very hard for an institution of our size to survive. It’s never been as tough as this.”
Lumina Review of Learning Frameworks: Tools for Building a Better Educational Experience
Authors: Shannon Tony
Published: July 2023

A reason for summarising this document (Travers et al, 2019) is that the Lumina Foundation in the USA is one of the few educational think-tanks which seems to be aware of the effects on the workplace from the exponentially accelerating growth in soft-computing, especially artificial intelligence, which will be seen in the next fifteen years (cf. Jankowski and Marshall. 2017).
Boyer Model of Scholarship in Practice
Authors: Shannon Tony
Published: July 2023

The four types of scholarship in the Boyer framework are relevant to teaching or training at any level of post-secondary education, both directly in terms of knowledge and indirectly through the impact of enthusiasm [2,9]. This outline is a simplified introduction to the salient features of the system, with some general examples of what each type could mean in practice. The boundaries of the types are fluid and can overlap in theory and in practice [4,6].
How are senior citizens capable to cope with the world of digital natives?
Authors: Westerholm Hely , Takanen-Körperich Pirjo
Published: July 2023

This study discusses the continuously growing threat to the senior citizens*), later called seniors, who can be isolated from the society if their digital competences and experiences are too poor in today’s digital world. It has been noted that to cope with one’s pursuits seniors need to actively construct and maintain their capabilities in ways that are flexible in the world of the digital devices, in response to the changing vicissitudes of life. Thus, the claim above illuminates the issue that the ability to learn from experiences is highly valued in the digital world. The seniors are obliged to closely take into consideration the changes in the environment and also flexibly respond to them as we live in the world of constantly unexpected incidents and changes. In future, the seniors are more and more expected to accept the modernized and renewed digital systems to be able to survive in everyday life. The results of this study indicate that the readiness, willingness and ability to develop oneself digitally are influenced partly by the knowledge and skills resulting from the studies and work experience, and also partly by the necessity and force of the digital world. The global challenges call seniors for new directions in education and training. The final outcome of this study helps digital trainers and specialists to educate on the curriculum basis senior trainees in the subjects which require their digital skills. Consequently, the seniors want to be regarded as good citizens also in this digital field.
The Effect of Technostress on the Motivation to Teach Online in Higher Education Before and During the COVID-19 Pandemic: Perceptions of Business Faculty
Authors: Boyer-Davis Stacy , Berry Kevin , Cooper Amy
Published: July 2023

This study investigated the relationships among technostress creators (techno-complexity, techno-insecurity, techno-invasion, techno-overload, and techno-uncertainty) on the motivation to teach online using the Motivation to Teach Online – Faculty Version scale. Data were collected from faculty members of the Management and Organizational Behavior Teaching Society (MOBTS), a member of the AACSB Business Education Alliance, and the American Society of Business and Behavioral Sciences (ASBBS), an interdisciplinary professional organization comprised of faculty teaching in accounting, finance, management, marketing, organizational behavior, and computer information systems early 2020 (N = 307). The findings indicated that techno-stressed faculty are less motivated to teach online. Techno-insecurity and techno-overload subconstructs were statistically significant pre-pandemic. Techno-insecurity was statistically significant during the pandemic. Gender and years of teaching online were not observed among faculty to modify online teaching motivations. Results are presented to supply institutions of higher learning with evidence to support faculty with online learning undertakings while leveraging opportunities to manage enrollment.
Establishing Cueing Skills When Treating Bilingual Speech Sound Disorders
Authors: Irizarry-Pérez Carlos , Lugo-Neris Mirza , Martinez-Fisher Andrea
Published: July 2023

Purpose: This study sought to train cueing skills in first-year graduate students when working with bilingual children with speech sound disorders to ensure fidelity of intervention of a larger research investigation. Method: Before explicitly training cueing skills, three students were randomly assigned bilingual clients that had been previously diagnosed with a speech sound disorder and asked to administer trial therapy. During the instructional phase, we gave students a cueing protocol, a scoring template, and feedback. We assessed performance according to challenge-point criteria and adherence to our cueing protocol. Results: Performance varied per student, but overall scores were higher during the instructional phases than during the baseline phase for all students. Performance was also higher when the students participated in individual conferencing versus group conferencing. Conclusion: Although the data are limited, the results suggest that a cueing protocol is supportive in establishing cueing skills in first-year graduate students administering speech sound intervention.
Gender Diversity Cultural Responsiveness Education in Speech-Language Pathology Graduate Programs: A Pilot Survey
Authors: Dickinson Tara , Normandin Molly , Mulheren Rachel
Published: July 2023

Purpose: Gender-affirming voice therapy aims to align a person’s voice and communication with their gender identity. Historically, transgender and gender-nonconforming (TGNC) individuals have been marginalized and continue to face significant healthcare disparities. The goal of this research was to examine the self-perceived preparedness of recent speech-language pathology (SLP) graduates for working with TGNC clients. A survey was developed to include both multiple choice and open-ended questions. Topics included graduate-level training on working with TGNC individuals, perceived preparedness to work with this client population, educational resources sought by respondents, and suggested improvements for SLP graduate programs. Thirty recent (since 2016) SLP graduates completed the survey anonymously. Although a majority (83%) of respondents reported that working with TGNC clients was addressed in their graduate education, 66% of respondents felt that instruction time spent on this topic was insufficient or slightly insufficient. Those who had clinical experiences with TGNC clients, or who learned from the perspectives of the TGNC community (e.g., from a guest speaker or video), reported that their graduate education better prepared them to work with TGNC clients. One of the most common recommendations to improve graduate education was to invite TGNC speakers to share their experiences. The majority of respondents identified a need for improvement of gender diversity education in SLP graduate programs. Further research is needed to determine the efficacy of different curricula in increasing the knowledge and skills of SLP graduates specific to TGNC clients to ensure clinical competency and equitable care.
Use of a Standardized Tracheostomy Patient Simulation to Evaluate Student Clinical Communication Skills
Authors: Stead Amanda , Tinsley Jordan , Mandulak Kerry , Michael Paul , Deiner Helene
Published: July 2023

Simulation is a valid pedagogical tool used to teach students, observe student clinical skills, and to assess clinical competencies. During the COVID-19 pandemic, a lack of medical speech-language pathology placements required graduate programs to re-examine clinical training. Simulation has proven useful in providing an alternative and safe learning modality. Standardized patients, which are one simulation modality, provide increased standardization and higher fidelity than medical manikins. This is particularly true in the context of both student learning and demonstration of clinical communication skills (CCS) within a simulated learning environment where the simulated patient can interact authentically with the student clinician. CCS are important because they can lead to better treatment outcomes and strengthen the therapeutic alliance. The purpose of this study was to evaluate the evidence for a CCS training in the context of a speaking valve trial with a standardized tracheostomy patient. Results showed that students are demonstrating emerging skills or have already developed CCS in this context. Student questionnaire ratings suggest that this simulation was helpful to their learning as it provided a safe environment for them to practice valuable clinical skills. Simulation appears to be a viable modality to use when training CSD students to improve their CCS.
Enriching Pre-Clinical Education with Near-Peer Learning Experiences
Authors: Springle Alisha , Pfeiffer Danika , Gillis Corrin
Published: July 2023

The purpose of this mixed methods study was to examine the outcomes of two instructional methodologies (traditional and peer-assisted learning; PAL) used in a clinical methods course for undergraduate speech-language pathology (SLP) students. The sample included 53 undergraduate SLP students (near-peer learners) as well as 27 graduate SLP students and 7 clinical fellows (near-peer tutors). Traditional instruction was used during the first half of the course and PAL was added during the second half. The undergraduate SLP students’ weekly written reflections and grades (mid-term and final) were collected for analysis. Students demonstrated a preference for peer- and near-peer learning experiences and commented positively on learning via stories throughout the course. They exhibited more positive attitudes during PAL instruction. Further, students reported less clinical confidence and more confusion as the course progressed and they learned more about the demands and expectations for clinical practice. Implications and recommendations for SLP students’ clinical training are discussed.
Student Preferences for Active Learning and Their Beliefs, Experiences, and Knowledge
Authors: Shilling Tammy , Thayer Jerome , Coria-Navia Anneris , Ferguson Heather
Published: July 2023

Active teaching methods are believed to facilitate higher-order thinking skills and prepare allied health students for independent clinical decision-making. This quantitative, correlational study aimed to explain the relationships between student preferences for active over traditional methods and their beliefs, the frequency and positiveness of their experiences, and the extent of knowledge they have received regarding active and traditional teaching methods. Two hundred and thirty students completed a 53-item online survey. Students were enrolled in a Doctor of Physical Therapy, Masters in Speech-language Pathology, or Bachelor of Science Nursing program in one of seventeen participating institutions across a ten-state Midwest region. A combination of student knowledge, student beliefs, and positive student experiences with active over traditional methods predicted 72.5% (R2 = .725, p = <.001) of the variance of student preferences for active methods. When students have clarity about the expectations of active learning methods, how they benefit their learning, believe they are responsible for learning and take the initiative, and perceive a positive experience, they prefer active methods over traditional methods. The results inform health professional education programs with recommendations that influence pedagogical change to support faculty and prepare students for clinical practice, higher-order thinking skills, and workforce expectations.
Structured Ethics Education in Speech-Language Pathology Graduate Students
Authors: Gaylord Jennifer , Schaaf Stephanie , Liljequist Laura , Guffey Kristie
Published: July 2023

This investigation compared the effect of ethics training embedded within a curriculum to structured ethics training regarding the ethics knowledge and self-reported comfort levels of first-year graduate students in speech-language pathology. Two equal, non-randomized groups of participants completed an ethics test and survey at three different times over the course of the investigation. The test and survey were administered prior to and after structured ethics training and ethics training embedded within the curriculum. The results of this study showed a significant difference in ethics knowledge after completion of the structured ethics training module for both groups. After receiving structured ethics training, there was no difference between groups regarding comfort in identifying and solving ethics problems. These findings add to the literature regarding the need for structured ethics training for graduate students in healthcare professions. Structured ethics training in speech-language pathology graduate students increased the knowledge of ethical foundations and decision-making models prior to clinical practice in the field.
Биологически активные вещества и ноотропная активность растительного средства
Authors: Корнопольцева Т. , Ботоева Е. , Шурыгина Ю. , Корнопольцева Л. , Корнопольцева М.
Published: July 2023

На основе рецептурной прописи тибетской медицины разработан растительный экстракт сухой (РЭС), состоящий из плодов тмина (Carum carvi L.), корней имбиря (Zingiber officinale Roscoe) и плодов мускатного дерева (Myristica fragrans Houtt.). Методом ВЭЖХ в РЭС установлено наличие 5 маркерных компонентов, сырьевым источником которых являются плоды тмина обыкновенного (5-кофеилхинная кислота, кверцетин-3-О-глюкозид), корневища имбиря лекарственного (6-гингерол, зингиберен), плоды мускатного дерева (миристицин). Доминирующими соединениями экстракта являются фенолы (миристицин, зингиберен), суммарное содержание которых составило 2,08 мг/г от массы РЭС (0,2 %); на долю алкалоидов (гингерол) приходится 0,52 мг/г (0,052 %), флавоноидов (кверцетин-3-О-глюкозид) — 0,59 мг/г (0,059 %), фенолкарбоновых кислот — 0,27 мг/г (0,027 %). Разработана методика стандартизации экстракта по сумме флавоноидов в пересчете на кверцитрин. Для количественного ­определения содержания суммы флавоноидов целесообразно использовать метод дифференциальной спектрофотометрии при аналитической длине волны 402 нм, используя при этом в методике анализа ГСО кверцитин-3-O-гликозид (кверцитрин). С использованием разработанной методики проанализирован ряд образцов РЭС и показано, что содержание суммы флавоноидов в образцах варьирует в пределах от 0,64 до 1,04 %. Исследуемый РЭС стимулирует ориентировочно-исследовательскую реакцию животных, помещенных в новые условия, снижается уровень тревожности и ускоряется период их адаптации к новым условиям. Курсовое введение РЭС сопровождается существенным увеличением их познавательной активности. РЭС обладает ноотропной активностью, при этом наиболее выраженную активность экстракт проявлял при многократном профилактическом введении в объеме 10,0 мл/кг массы тела.
Клеточные и тканевые механизмы ингибирования фактора роста эндотелия сосудов при экспериментальном остеоартрите
Authors: Кабалык М. , Невзорова В. , Дубов В. , Цыганков М. , Коваленко Т.
Published: July 2023

Оценено влияние ингибитора фактора роста эндотелия сосудов (VEGF) на ремоделирование тканей суставов при экспериментальном остеоартрите (ОА). На животной модели ОА, полученной в результате низкоэнергетической малоинвазивной травме тканей суставов у морских свинок, показано, что внутрисуставные инъекции ингибитора VEGF бевацизумаба демонстрируют хондропротективные и остеопротективные эффекты. Бевацизумаб препятствует патологическому ангиогенезу и деградации суставного хряща, ремоделированию субхондральной кости. Результаты исследования подтверждают важную патогенетическую роль VEGF при ОА и указывают на перспективы использования ингибиторов VEGF в консервативном лечении ОА.
Разработка и валидация методики определения аминокислот в листьях облепихи крушиновидной
Authors: Ковалева Н. , Тринеева О. , Сливкин А.
Published: July 2023

Разработана методика количественного определения суммы свободных аминокислот в пересчете на глутаминовую кислоту методом дифференциальной спектрофотометрии в листьях облепихи крушиновидной, проведена ее валидационная оценка. Выбраны оптимальные параметры выделения аминокислот из листьев облепихи. Исследовано содержание свободных аминокислот в листьях, заготовленных в различные фенологические фазы жизни растения, для выявления динамики накопления данных БАВ. Полученные результаты свидетельствуют о валидности методики и возможности ее применения для определения БАВ (свободных аминокислот) в изучаемом лекарственном растительном сырье. Максимальное содержание суммы аминокислот (в пересчете на глутаминовую кислоту) характерно для листьев, заготовленных в начале июня (фенофаза I). Для фазы единичного созревания плодов выявлено снижение содержания вплоть до конца августа – фаза массового созревания плодов.
Моделирование взаимодействия липосомы с винпоцетином с плоской клеточной мембраной методом молекулярной динамики
Authors: Полковникова Ю.
Published: July 2023

Представлены результаты моделирования процесса сборки липосомы из фосфолипидов соевого лецитина в присутствии винпоцетина, а также взаимодействия липосомы с винпоцетином с плоской клеточной мембраной методом молекулярной динамики. Образование липосом сферической формы из очищенного соевого лецитина в водной среде в присутствии винпоцетина в кислой среде происходит самопроизвольно при концентрации лецитина 5 % по массе при 298 К в течение 3 мкc. Молекулы винпоцетина располагаются как на внутренней, так и на внешней поверхности липосомы. Во внутренней полости образовавшейся липосомы располагается 51 молекула винпоцетина. По результатам моделирования крупнозернистой молекулярной динамики липосома из очищенного соевого лецитина с винпоцетином, адсорбированным на ее внутренней и внешней поверхностях, способна сливаться с клеточной мембраной эндотелиоцита. Молекулы винпоцетина, находящиеся внутри липосомы в процессе слияния липосомы с клеточной мембраной, располагаются на внутриклеточной поверхности цитоплазматической мембраны эндотелиоцита.
Impacto de la cardiomiotomía laparoscópica de Heller en la función del esfínter esofágico inferior y el diámetro del esófago
Authors: Arias-Madrid Natalia , Henao-Builes María Lizette , Ricaurte-Ciro Juan Camilo , Toro-Vásquez Juan Pablo
Published: July 2023

Introducción. La acalasia es un trastorno motor del esófago caracterizado por la ausencia de peristalsis y la alteración en la relajación del esfínter esofágico inferior. La cardiomiotomía laparoscópica de Heller más funduplicatura parcial es el tratamiento estándar. La mejoría sintomática ha sido bien documentada, pero no hay suficiente información objetiva respecto a los cambios fisiológicos y radiográficos luego del procedimiento.
Métodos. Estudio de cohorte bidireccional de pacientes llevados a cardiomiotomía laparoscópica de Heller, entre los años 2018 y 2021, en el Hospital Universitario San Vicente Fundación de Medellín, Colombia. Se describen variables demográficas y clínicas. Se realizaron puntaje sintomático de Eckardt, manometría esofágica y radiografía de esófago en el pre y postoperatorio. Se hizo comparación de síntomas, presión basal del esfínter esofágico inferior, presión de relajación integrada y diámetro del esófago antes y después de la intervención.
Resultados. Se incluyeron 24 pacientes. El 63 % fueron mujeres y la edad promedio fue de 44 años. Los valores promedio preoperatorios vs postoperatorios fueron: puntaje de Eckardt 10,6 vs 1,4 puntos (p<0,001), presión basal de 41,4 vs 18,1 mmHg (p=0,004) y presión de relajación integrada de 28,6 vs 12,5 mmHg (p=0,001). El diámetro del esófago no presentó cambios. No hubo correlación de síntomas con los cambios de presión del esfínter esofágico inferior. El tiempo de seguimiento fue de 20 meses.
Conclusiones. La cardiomiotomía de Heller es un procedimiento altamente efectivo para el tratamiento definitivo de la acalasia, logrando una mejoría subjetiva y objetiva basada en síntomas y en parámetros de manometría, respectivamente.
Estomas: complicaciones, manejo y prevención. Una revisión actual
Authors: Gómez-Romero Juan Camilo , Mosquera-Romero María Camila
Published: July 2023

Introducción. La resección segmentaria del intestino y su derivación temporal o definitiva es un procedimiento frecuente en la práctica quirúrgica, que implica la construcción de un estoma. La enfermedad que lleva a la cirugía, las condiciones clínicas del paciente y los aspectos técnicos en la construcción de la ostomía son puntos claves en la evolución posoperatoria.
Métodos. Se realizó una revisión de la literatura identificando las complicaciones asociadas a la construcción de estomas, con el objetivo de ofrecer herramientas de tratamiento y toma de decisiones al personal médico involucrado en la atención de estos pacientes.
Resultados. La cirugía de urgencia, la inmunosupresión, la obesidad y la técnica en la apertura del orificio en la pared abdominal, favorecen la aparición de complicaciones tempranas que requieren manejo médico o reintervención quirúrgica.
Conclusiones. Todo paciente con estoma debe ser valorado minuciosamente por el cirujano y la terapista enterostomal en las primeras 72 horas luego de la cirugía.
Den Mund zum Reden in Gleichnissen öffnen
Authors: Euler Alida C.
Published: July 2023

The Psalms are an important source for the intertextual grid that underlies the Gospel of Matthew. Particularly, Matthew refers to them in several key passages throughout his gospel (e.g. Ps 91:11f. in Mt 4:6; Ps 110:1 in Mt 22:44; 26:64, Ps 69:22 in Mt 27:34.48; Ps 22 in Mt 27:35.39.43.46). Within the Parable Discourse (Mt 13:1–52) Matthew quotes Ps 78:2 as a ‘fulfillment quotation’ (Mt 13:35). After concluding that most likely the wording of Mt 13:35 does not contain a specification of καταβολή, Matthew’s source for this intertextual reference is determined to be ‘the’ Septuagint, which he changes in the second part of the quotation due to interpretational reasons. Within its closer context this reference to Ps 78:2 serves Matthew to differentiate between the crowds who merely hear what was hidden and the disciples who both hear and understand. For this purpose, Matthew has to refer to Ps 78:2 in an atomistic way. This proves that Matthew is in principle willing to atomisticaly use a psalm, which in turn is important for the discussion of the use of other psalms within the gospel – especially on the extensive use of Ps 22 within the Matthean crucifixion scene.
Was Bleibt: Spektrale Infrastrukturen kolonialer Extraktion im Kontext Namibias
Authors: Gunkel Henriette
Published: July 2023

Dieser Beitrag nimmt Kaganofs Experimentalfilm Western 4.33 (34 Min. 2002) zum Ausgangpunkt, der im Süden Namibias, in der !Namib Wüste, ehemalige Orte und Infrastrukturen der Diamantenextraktion im Kontext des deutschen Genozids an den OvaHerero und Nama in Szene setzt. Dies tut er, wie der Titel schon andeutet, auf der Ebene des Sounds als auch des Bildes und wirft dabei Fragen nach dem ‚Infra‘ in Infrastruktur auf, also dem, was der Infrastruktur unterliegt und sich unserer Wahrnehmung immer wieder entzieht. In diesem Beitrag interessieren mich die haunted places of absence einer kolonialen Infrastruktur der Extraktion und mit welchen ästhetischen Strategien diese wahrnehmbar gemacht werden sowie die von Vanessa Agard-Jones aufgeworfene Frage was der Sand erinnert.
Anatomía foliar de especies predominantes en bosques y pastizales del Iberá
Authors: Gómez Norma E. , Angulo María B. , Gonzalez Ana M.
Published: July 2023

El macrosistema Iberá presenta diversos tipos de vegetación, donde además de las acuáticas y palustres hay bosques hidrófilos, sabanas con predominio de gramíneas y praderas con especies arbustivas intercaladas entre las herbáceas. Estudios previos de anatomía foliar solo fueron realizados en plantas acuáticas y palustres. En este trabajo se estudió la anatomía foliar en especies predominantes o frecuentes que crecen en pastizales y bosques del macrosistema Iberá, con el objetivo de detectar caracteres estructurales de las hojas que puedan representar valor adaptativo a estos ambientes. Se analizaron hojas de 42 especies correspondientes a 26 familias, con microscopía óptica y electrónica de barrido. Se realizó un análisis estadístico en base a una matriz de datos, compuesta por los caracteres anatómicos y el ambiente en que crecen las especies estudiadas. Los caracteres analizados de la epidermis fueron: diseño de la cutícula, estomas, tricomas, diseño de células epidérmicas de ambas epidermis, donde se observa un predominio de idéntica morfología en ambas caras. En el mesofilo se evaluó su tipo, presencia y forma de cristales de calcio e inulina, y distribución de estructuras glandulares como laticíferos, cavidades y células secretoras. Los datos reportados son discutidos en relación a la bibliografía disponible. El análisis de agrupamiento (UPGMA) muestra que las especies que habitan en los mismos ambientes no presentan características anatómicas similares.
DEFENSE MECHANISM IN THE CHARACTER OF HARDIN SCOTT REFLECTED IN ANNA TODD’S AFTER
Authors: Shelah Siti Nur , Marsih Linusia
Published: July 2023

This thesis tries to analyze a fiction novel written by an American writer, Anna Todd with the novel titled After. This thesis tells about the background faced by Hardin and also his father until there was an unresolved conflict in the relationship between Hardin and his father and Tessa as Hardin's closest person. Here the author focuses on one of the first characters, namely Hardin, his defense mechanisms, and how he shows them.  The method used for this thesis is qualitative description because this thesis aims to explain the defense mechanism of the main character in After novel. The data used is taken from the novel itself. The author uses Sigmund Freud's theory of self-defense mechanisms as the main theory to work on this thesis. The data is analyzed by reading, understanding, and identifying. With this analysis, the writer finds that the first character uses denial, projection, rationalization, isolation, identification of aggressors, and displacement. The first character uses this defense mechanism to shape himself so that anxiety does not occur, therefore the main character forms a self-defense mechanism.
SLANG WORDS USED IN YOUTUBE VIDEO JOJI JUDGES A BOBA TEA BATTLE BETWEEN RICH BRIAN AND NIKI: A SOCIOLINGUISTIC STUDY
Authors: Lestari Trya Indah , Alfatihah Felesya Hijrian , Rania Nurul Athalla , Turnip Gracesila Hanna Caroline , Rudianto Gaguk
Published: July 2023

This research aimed to analyze the slang words found in the YouTube video Joji Judges a Boba Tea Battle between Rich Brian and Niki. To find out the types of slang used by participants in the video. This descriptive qualitative research focused on the types of slang words in this video according to Alan and Burridge theories. Method of collecting data by the observation in the observational method with non-participatory technique. In analyzing the data, this research used the method of free listening and take note technique proposed by Sudaryanto. From this research, the results showed that there were 30 data of slang: 2 slang terms in flippant such as I was like ready to rip on it, 4 slang terms in clipping, 4 slang words in imitative, and 20 slang words in fresh and creative, and there are no slang words in the acronym. Based on the results, it can be concluded that the most widely used slang type is the acronym form and the least flippant.
AN ANALYSIS OF REPRESENTATIVE IN DONALD TRUMP’S IMPEACHMENT CAMPAIGN
Authors: Neonbanu Eny Akwila
Published: July 2023

This research is an analysis of representative in Donal Trump’s impeachment campaign. The aim of this reasearch is to know how Donal Trump applied representative to persuade the hearers. How a speech of Donal Trump could affect the audience to do something for him to win the second election. In this study, the researcher used qualitative method, and the data were collected from a speech text. The transcript speech text of Donal Trump’s utterances consisting of representative was the instrument of this research. Then, to find and analyze the representative showed in the text speech, the researcher used a theory of John R. Searle (1969) which explains that representative is one of the illocutionary acts that the utterance with the intention to commit the speaker to do something with the truth of expressed proposition. The representatives found in this research were, 1 representative of stating, 3 representatives of informing, 1 representative of predicting, 1 representative of reporting, 1 representative of describing, 1 representative of complaining, 1 representative of claiming, and 2 representatives of asserting. In this study showed that Donal Trump succeed inciting the hearers making a riot to the capitol by believeing in his statements on his impeachment campaign. How his utterances were manipulative and making the audience agreed to the statements he said.  The researcher hopes that this analysis would be useful who would like to learn about speech act and illocutionary act, especially about representative illocutionary act.
LISTENING STRATEGIES USED BY THE FOURTH SEMESTER STUDENTS AT ACADEMIC LISTENING CLASS
Authors: Like Enjelina , Lantu Ika Paramitha , Poai Sherliane Trisye
Published: July 2023

The Objective of this research is to find out the strategies used by the fourth semester students at English Education Study Program of Sintuwu Maroso University. This research is a descriptive qualitative that used questionnaire, interview and documentation as the instruments to collect data. Theory used in this research are the theory of learning strategies from Chamot and O’Malley. After analyzing the obtained data, it is found that the fourth semester students used cognitive, metacognitive and socio-affective strategies to help them in learning academic listening.  The findings showed that the students used cognitive, metacognitive and socio-affective strategies based on the questionnaire result but on the interview result the students used cognitive strategies. Based on the result, it can concluded the students used the strategies to help them in learning academic listening.
POSITIVE AND NEGATIVE POLITENESS STRATEGIES REFLECTED IN "GOLDELINE" NOVEL BY JIMMY CAJOLEAS: PRAGMATIC APPROACH
Authors: Marceline Florencia Sandra , Mubarak Zia Hisni
Published: July 2023

Being polite should be important regardless of age. This research aimed to analyze how adults used positive and negative politeness strategies based on the politeness theory by Brown and Levinson (1987) to talk politely to a young girl and boy. The data source is a 2017 novel titled “Goldeline” which was written by Jimmy Cajoleas. The novel revolves around how Goldeline, an 11-year-old girl, ran away from the Preacher who wanted to take her life. On her journey, Goldeline met a lot of adults and as she was a young girl, the adults talked to her politely. Qualitative research method is applied to discuss the research. It is found that positive politeness was used more frequently than negative politeness. The most frequently used positive politeness strategy was the fourth strategy, which is using in-group markers; used in 23 data. As for the negative politeness, the most frequently used strategy was the seventh strategy, which is impersonalizing speaker and addressee; used in 16 data.
AN ANALYSIS OF CONVERSATIONAL IMPLICATURE OF THE CHARACTERS IN THE BIRD BOX FILM
Authors: Kelvin Kelvin , Mubarak Zia Hisni
Published: July 2023

. To accomplish the goals of an ability to understand, it is anticipated that everyone involved in the communication process will work together. However, in practice, sending purposes are not usually expressed clearly. In reality, a person might not reach the part of the conversation where they are required to speak openly, intelligibly, pertinently, and appropriately so that the other person can understand them incredibly well. This phenomenon is referred to as conversational implicature in linguistic terms, where individuals prefer to indicate their additional or hidden meaning that is delivered behind spoken words. By using Grice's theory to determine implicature form for portraying conversation context, which determines the factors that influence communication, this research aims to examine the phenomenon in the conversation of the two main characters in the Bird Box film. The researcher used the conversational implicature theory by Grice (1975) to identify the utterance and the speech acts theory by Searle (1976) to categorize the function. Searle (1976) classified speech acts identified are representatives/assertives, instructions, commissives, expressives, and declarations. This study has a qualitative research design. The researcher employed the Sudaryanto (2015) interview method to gather data, the Sudaryanto (2015) pragmatic identity method to analyze the data, and the Sudaryanto (2015) informal presentation approach to convey the research findings. The researcher gathered ten data sets with conversational implicature in order to examine the data.