bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlations Between mammographic breast density and outcome after neoadjuvant chemotherapy in patients with locally advanced breast cancer.
Authors: AGARWAL Veenoo , Spalding Lisa , Martin Hilary , Darcey Ellie , Stone Jennifer , Redfern Andrew
Published: August 2023

Background – The inverse association between high mammographic breast density (MBD) and pathologic complete response (pCR), following neoadjuvant chemotherapy (NAC) for early breast cancer (BC), implicates high MBD in chemotherapy resistance. However, no trial has extended the relationship beyond pCR to overall survival.
Aim - To validate the relationship between MBD and pCR in patients undergoing NAC for early BC. To assess the relation of MBD with clinical complete response (cCR), relapse-free (RFS) and BC-specific survival (BCSS).
Methods – MBD was measured in contralateral mammograms in 127 women before NAC, using Cumulus software. Percent dense area (PDA) was correlated with patient and tumour characteristics, short-term (pCR/cCR incidences), and long-term chemotherapy outcomes (RFS and BCSS).
Results - Overall rates of cCR and pCR of 49% and 21% were observed. Mean MBD was higher in those not undergoing cCR (p = 0.041) and relapsing patients (p = 0.041) but did not vary by pCR or BC-deaths. As a dichotomous variable, high MBD corresponded to lower cCR (40 v 58%, p = 0.027). No difference was seen between high and low MBD cohorts for pCR (17.5 v 25.0%, p = 0.15), BC relapse (38 v 30%, p = 0.15) or BC-death (32 v 25%, p = 0.20). A planned analysis in obese patients demonstrated high MBD was associated with lower pCR (0% v 28.1%, p = 0.036) and higher relapse rates (56% v 28%, p = 0.063). No such relationship was observed in non-obese patients.
Conclusion – high MBD associated with lower cCR and higher relapse but not with pCR or BC death. Further analysis, including by body mass index, is warranted.
Global incidence and mortality trends of gastric cancer and predict mortality of gastric cancer by 2035
Authors: Lin Ju-Li , Lin Jian-Xian , Lin Guang-Tan , Huang Chang-Ming , Zheng Chao-Hui , Xie Jian-Wei , Wang Jia-bin , Lu Jun , Chen Qi-Yue , Li Ping
Published: August 2023

Objective
To study the historical global incidence and mortality trends of gastric cancer and predict mortality of gastric cancer by 2035.
Methods
Incidence data were retrieved from the Cancer Incidence in Five Continents (CI5) volumes I-XI, and mortality data were obtained from the latest update of the World Health Organization (WHO) mortality database. We used join-point regression analysis to examine historical incidence and mortality trends and used the package NORDPRED in R to predict the number of deaths and mortality rates by 2035 by country and sex.
Results
More than 1,089,000 new cases of gastric cancer and 769000 related deaths were reported in 2020. The average annual percent change (AAPC) in the incidence of gastric cancer from 2003 to 2012 among the male population, South Korea, Japan, Malta, Canada, Cyprus, and Switzerland showed an increasing trend (P > 0.05); among the female population, Canada [AAPC, 1.2; (95%Cl, 0.5-2), P < 0.05] showed an increasing trend; and South Korea, Ecuador, Thailand, and Cyprus showed an increasing trend (P > 0.05). AAPC in the mortality of gastric cancer from 2006 to 2015 among the male population, Thailand [3.5 (95%cl, 1.6–5.4), P < 0.05] showed an increasing trend; Malta Island, New Zealand, Turkey, Switzerland, and Cyprus had an increasing trend (P > 0.05); among the male population aged 20–44, Thailand [AAPC, 3.4; (95%cl, 1.3–5.4), P < 0.05] showed an increasing trend; Norway, New Zealand, The Netherlands, Slovakia, France, Colombia, Lithuania, and the USA showed an increasing trend (P > 0.05). It is predicted that the mortality rate in Slovenia and France’s female population will show an increasing trend by 2035. It is predicted that the absolute number of deaths in the Israeli male population and in Chile, France, and Canada female population will increase by 2035.
Conclusion
In the past decade, the incidence and mortality of gastric cancer have shown a decreasing trend; however, there are still some countries showing an increasing trend, especially among populations younger than 45 years. Although mortality in most countries is predicted to decline by 2035, the absolute number of deaths due to gastric cancer may further increase due to population growth.
Tracking the migration and distribution of Caspian Kutum (Rutilus kutum, Kamenskii, 1901) along the southern coastline of the Caspian Sea: Using stable isotope analysis
Authors: Abbasi Fatemeh , Ghorbani Rassoul , Salmanmahiny Abdol Rassoul , Trueman Clive Nicholas , Jackson Andrew Llyod , Fazel Abdol Azim
Published: August 2023

Evaluating management strategies for fish catch development requires knowledge of movement patterns and their spatial distribution. The Caspian kutum (Rutilus kutum, Kamenskii, 1901) is an important commercial species throughout the southern coasts of the Caspian Sea. Stable isotope ratios are powerful indexes that simplify the understanding of the migration of aquatic animals. This research determined the stable isotope ratio of carbon (δ13C) and nitrogen (δ15N) for Rutilus kutum movement at 10 sites along the southern coastline of the Caspian Sea from January to December 2017. Spatial and temporal variations in stable isotope values of the coastal communities in the Caspian Sea remain poorly understood. These findings suggest that individual variation, but with a strong overall decline in δ13C and increasing in δ15N and δ13C/δ15N ratio with age, too. These isoscpes showed that the δ15N ratio increased and δ13C decreased from the east (Gomishan) to the west (Astara).
Assessing the integrity of auditory sensory memory processing in CLN3 disease (Juvenile Neuronal Ceroid Lipofuscinosis (Batten disease)): An auditory evoked potential study of the duration-evoked mismatch negativity (MMN).
Authors: Brima Tufikameni , Freedman Edward G. , Prinsloo Kevin D. , Augustine Erika F. , Adams Heather R. , Wang Kuan Hing , Mink Jonathan W. , Shaw Luke H. , Mantel Emma P. , Foxe John J.
Published: August 2023

Background: We interrogated auditory sensory memory capabilities in individuals with CLN3disease (juvenile neuronal ceroid lipofuscinosis), specifically for the feature of “duration” processing, a critical cue in speech perception. Given decrements in speech and language skills associated with later-stage CLN3 disease, we hypothesized that the duration-evoked mismatch negativity (MMN) of the event related potential (ERP) would be a marker of progressively atypical cortical processing in this population, with potential applicability as a brain-based biomarker in clinical trials.
Methods: We employed three stimulation rates (fast: 450 ms, medium: 900 ms, slow: 1800 ms), allowing for assessment of the sustainability of the auditory sensory memory trace. The robustness of MMN directly relates to the rate at which the regularly occurring stimulus stream is presented. As presentation rate slows, robustness of the sensory memory trace diminishes. By manipulating presentation rate, the strength of the sensory memory trace is parametrically varied, providing greater sensitivity to detect auditory cortical dysfunction. A secondary hypothesis was that duration-evoked MMN abnormalities in CLN3 disease would be more severe at slower presentation rates, resulting from greater demand on the sensory memory system.
Results: Data from individuals with CLN3 disease (N=21; range 6-28 years of age) showed robust MMN responses (i.e., intact auditory sensory memory processes) at the medium stimulation rate. However, at the fastest rate, MMN was significantly reduced, and at the slowest rate, MMN was not detectable in CLN3 disease relative to neurotypical controls (N=41; ages 6-26 years).
Conclusions: Results reveal emerging insufficiencies in this critical auditory perceptual system in individuals with CLN3 disease.
Synergistic evolution of stable bioactivity and better mechanical strength in polyvinyl alcohol and sweet lime peel film
Authors: Arora Ritika , Agarwal Aparna , Haleem Rizwana , Shukla S.K.
Published: August 2023

The present study discloses the evolution of bioactivity with improved chemical stability in the composite film of polyvinyl alcohol (PVA) and sweet lime peel (SLP) powder along with biodegradability and improved hardness due to the structural miscibility between constituents polymer during solution blending. The evolved structure, properties, bioactivity, and synergistic effect between PVA and SLP were established with the help of spectrochemical results, morphological results, and physio-mechanical properties i.e. thickness, chemical stability, water vapor transmission rate, heat seal-ability, and shelf-life. The result reveals the better preservation of the bioactive compound of SLP by 200%, antimicrobial nature against S. aureus and E. coli, improved tensile strength, and heat stability in the film. Further, the prepared film of SLP with optimum properties and 0.12 mm thickness was used for packing of sprouts as an alternative to currently used non-biodegradable film with comparable life span for seven days.
Multilevel Intervention of Resistance Training Combined with Beta- Hydroxy Beta-Methylbutyrate (RTCHMB) in Critical Illness during Hospitalisation: A Study Protocol of a Four-Arm, Multicentre, Randomised Controlled Trial
Authors: Wu Ting Ting , Mu Yan , Xiong Jing , Wei Yue Qing , Li Hong
Published: August 2023

Background
Early rehabilitation and nutrition interventions have been extensively studied to improve the physical function of ICU patients, but optimal strategies remain unclear. ICU-acquired weakness (ICU-AW) negatively impacts both short- and long-term patient outcomes, placing a significant burden on families and society alike. Resistance training, beta-hydroxy beta-methylbutyrate (HMB), and the combined intervention have widely been used in clinical populations, and have shown positive effects in enhancing physical function. However, their application in treating ICU patients is still relatively limited. The purpose of the present study is to determine whether resistance training and/or HMB administration would also enhance outcomes in critically ill patients.
Methods
This four-arm, accessor-blind, multicentre randomised controlled trial will be conducted in 10 ICUs at five centres in Fujian province, China. Eligible participants will be randomised in a 1:1:1:1 ratio to receive either resistance training (hierarchical resistance training), HMB group (HMB alone), combination group (a combination of both interventions), or usual care group (conventional rehabilitation and nutritional therapy). The intervention will be administered five times per week through supervised training, with each session lasting 20–30 min during the entire hospitalisation. The four categories— physical function and structure impairment, activity limitation, participation limitation, and quality of life—will be repeatedly measured at baseline, ICU to discharge, and hospital discharge. Data will be analysed using a generalised linear mixed model and will follow the principles of intention-to-treat analysis.
Discussion
This multicenter with four-arm design of RCT will investigate the efficacy of resistance exercise, HMB, and their combined utilization in enhancing physical function among ICU patients. The outcomes of our study will provide optimal rehabilitation strategies for the prevention of ICU-AW for clinical application, and serve as a foundation for future research endeavors in this field.
Trial registration:
ChiCTR2200057685 was registered on March 15th, 2022.
Flexible heat pumps: must-have or nice to have in a power sector with renewables?
Authors: Roth Alexander , Kirchem Dana , Gaete-Morales Carlos , Schill Wolf-Peter
Published: August 2023

Heat pumps are a key technology for reducing fossil fuel use in the heating sector. A transition to heat pumps implies an increase in electricity demand, especially in cold winter months. Using an open-source power sector model, we examine the power sector impacts of a massive expansion of decentralized heat pumps in Germany in 2030, combined with buffer heat storage of different sizes. Assuming that the additional electricity used by heat pumps has to be fully covered by renewable energies in a yearly balance, we quantify the required additional investments in renewable energy sources. If wind power expansion potentials are limited, the roll-out of heat pumps can also be accompanied by solar PV with little additional costs, making use of the European interconnection. The need for additional firm capacity and electricity storage generally remains limited even in the case of temporally inflexible heat pumps. We further find that relatively small heat storage capacities of 2 to 6 hours can substantially reduce the need for short- and long-duration electricity storage, other generation capacities, and power sector costs. We further show that 5.8 million additional heat pumps save around 120 TWh of natural gas and 24 million tonnes of CO2 emissions per year.
Multiplex attacks in sigmoid volvulus
Authors: Disci Esra , Peksoz Rifat , Agirman Enes , Atamanalp Refik Selim , Atamanalp Cansu Tatar , Atamanalp Sabri Selcuk
Published: August 2023

Purpose
Sigmoid volvulus (SV) recurs in about one quarter of the patients, whereas multiplex (≥3) attacks are quite rare and attacks with five or more times are extremely rare. The aim of this study is to evaluate multiplex SV attacks in our series and worldwide data.
Methods
In our 1,071-case series, data were evaluated retrospectively in 612 patients, while prospectively in 459 with respect to age, gender, previous volvulus attacks, and prognosis. Worldwide data were obtained from Web of Science database and they were compared with our results.
Results
Mean SV attack count, multiple- (≥2) and multiplex- (≥3)attack rates were 1.4, 26.1%, and 4.2%, respectively, in our series, while they were 1.7, 26.7%, and 3.2%, respectively, in worldwide data (p>0.05, in all). In our series, recurrence rates were 26.1%, 19.3%, and 51.2%, respectively, (p<0.001, in all), while mortality rates were 7.3%, 13.7%, and 19.5%, respectively, (p<0.001, in all) in single-, double-, and multiplex- (≥3) attack patients.
Conclusions
Although multiplex (≥3) attacks are uncommon in SV, when it goes up, elective surgery must be considered in selected cases to avoid repetitive attacks and related high mortality.
Meta-analysis of the correlation between BMI and risk factors for osteoporosis
Authors: Gong Yichen , Cai YunHuo , Li Ning
Published: August 2023

Objectives: The purpose of this meta-analysis is to assess whether there is an association between BMI and osteoporosis.
Methods: Domestic and foreign databases were searched for case-control studies published from 1990.1.1. to 2022.12.31, they use medical subject headings (MeSH) and keywords. All statistical analyses were performed using Review Manager 5.3. If I2 <50%, a fixed-effects model was adopted. If I2> 50% (which indicated great heterogeneity), a random-effects model was adopted.
Results: This meta-analysis included 18 case-control studies covering 9078 individuals, published between 1990 and 2022. The pooling analysis shows that low BMI is a risk factor for osteoporosis complicated by type 2 diabetes, high BMI is a risk factor for osteoporosis complicated by menopausal women, and low BMI is a risk factor for primary osteoporosis. The correlation between normal and high BMI and primary osteoporosis cannot be demonstrated yet; BMI is a risk factor for osteoporosis in patients with frequent glucocorticoid use or COPD, and the correlation between BMI and risk factors for osteoporosis in stroke patients cannot be demonstrated yet.
Conclusions: Our meta-analysis shows that low BMI is a risk factor for osteoporosis complicated by type 2 diabetes and primary osteoporosis, high BMI is a risk factor for osteoporosis complicated by menopausal women, and BMI is a risk factor for osteoporosis in patients with frequent glucocorticoid use or COPD. This provides a theoretical basis for the prevention of osteoporosis in clinical practice.
Sex differences and age-related changes in the mandibular alveolar bone mineral density using a computer-aided measurement system for intraoral radiography
Authors: Ono Ryutaro , Katsumata Akitoshi , Fujikawa Yumi , Takahira Emi , Yamamoto Toshiro , Kanamura Narisato
Published: August 2023

This study aimed to conduct a cross-sectional data analysis of the alveolar bone mineral density (al-BMD) in 225 patients of various ages and different sexes. The al-BMD value in the mandibular incisor region was calculated using a computer-aided measurement system (DentalSCOPE®) for intraoral radiography. All participants with intact teeth (101 males and 124 females; age range, 25–89 years) were divided into three age-segregated groups (25–49, 50–74, and > 75 years). Statistical differences were evaluated using the Mann–Whitney U or Kruskal–Wallis test. Males exhibited significantly greater al-BMD than females (p < 0.001). The highest means were observed in the 25–49 age group, regardless of sex (1007.90 mg/cm2 in males, 910.90 mg/cm2 in females). A 9.8% decrease in al-BMD was observed with the increase in age in males (25–49 to 50–74 years; p = 0.004); however, no further changes were seen thereafter. In females, a decreasing trend was seen throughout the lifespan, with values reaching up to 76.0% of the initial peak value (p < 0.001). Similar to other skeletal sites, the alveolar bone exhibits sex differences and undergoes a reduction in BMD via the normal aging process.
Clay-supported bio-based Lewis acid ionic liquid as a potent catalyst for the dehydration of fructose to 5- hydroxymthylfurfural
Authors: Yaghoubi Soheila , Sadjadi Samahe , Zhong Xuemin , Yuan Peng , Heravi Majid
Published: August 2023

Caffeine and halloysite nanoclay mineral were used as bio-based compounds to synthesize a novel Lewis acid heterogeneous catalyst. To prepare the catalyst, halloysite was functionalized with 2,4,6-trichloro-1,3,5-triazine and reacted with caffeine. Caffeine was then converted to ionic liquid via a reaction with ZnCl2. The catalyst was characterized using SEM/EDS/mapping, FTIR, TGA, XRD, BET and applied for promoting the dehydration of fructose to 5-hydroxymthylfurfural. To investigate the effects of the reaction variables, response surface methodology was used. The product was achieved in 98.5% in 100 min using a catalyst loading of 30 wt% at 100°C. Moreover, the catalyst was highly recyclable and stable. Comparison of the catalytic activity of the catalyst with that of halloysite and a control catalyst with one caffeine-based Lewis acid ionic liquid confirmed the superior activity of the former and the important role of 2,4,6-trichloro-1,3,5-triazine for increasing the number of the grafted caffeine and thus the acidic sites of the catalyst. A plausible reaction mechanism was proposed, and the activity of the catalyst for other carbohydrates was also studied. According to the results, this catalyst catalyzed the reaction of other substrates to furnish 5-hydroxymthylfurfural in low to moderate yields.
BONE MARROW OXALOSIS, A RARE CAUSE OF PANCYTOPENIA: A CASE REPORT
Authors:   Anatomy Pathology and Cytology Laboratory, CHU IBN SINA, 10000, Rabat, Morocco., Mouhoubo I. , Papys M. ,   Anatomy Pathology and Cytology Laboratory, CHU IBN SINA, 10000, Rabat, Morocco., Znati K. ,   Anatomy Pathology and Cytology Laboratory, CHU IBN SINA, 10000, Rabat, Morocco., Jahid A. ,   Anatomy Pathology and Cytology Laboratory, CHU IBN SINA, 10000, Rabat, Morocco., Zouaidia F. ,   Anatomy Pathology and Cytology Laboratory, CHU IBN SINA, 10000, Rabat, Morocco., Bernoussi Z. ,   Anatomy Pathology and Cytology Laboratory, CHU IBN SINA, 10000, Rabat, Morocco.
Published: August 2023

Primary hyperoxaluria is a rare congenital metabolic disease characterised by an overproduction of oxalate, secondary to a hepatic enzyme deficiency, alanine glyoxylate aminotransferase (AGT). Calcium oxalate crystals are deposited in many tissues. Involvement of the bone marrow is relatively rare. We report the case of a young 29-year-old patient with a history of recurrent renal lithiasis, progressing to end-stage chronic renal failure at the haemodialysis stage, admitted to the medical ward for investigation of mucocutaneous pallor and anaemia resistant to erythropoietin. Clinical and laboratory examination revealed an oedematous-ascitic syndrome and pancytopenia with normocytic normochromic anaemia. Imaging revealed moderate ascites and homogeneous splenomegaly. The myelogram was inconclusive. An osteomedullary biopsy was performed and showed deposits of oxalate crystals with bone marrow fibrosis associated with foreign body macrophagic granulomas. These crystals were grouped in a rosette and birefringent in polarised light. Primary hyperoxaluria is a rare disease. Involvement of the bone marrow indicates the advanced stage of the disease, hence the importance of anatomopathological diagnosis. Hepato-renal transplantation remains the only effective treatment for this disease.
REHABILITATION SERVICES FOR CHILDREN IN CONFLICT WITH THE LAW IN BAGUIO CITY
Authors:   University of Baguio Graduate School of Criminal Justice and Public Safety., May Pidlao-Palitayan Beca
Published: August 2023

The primary purpose of the study was to determine the services of the Bahay Pag-Asa (BPA) in Barangay Irisan, Baguio City, in terms of the available programs and activities, the challenges encountered during implementation, and the strategies that were employed to counter these challenges. The study made use of a qualitative descriptive design. An interview guide was utilized to collect the data. As part of the Juvenile Justice System, the selected participants were the members of the Barangay Council for the Protection of Children(BCPC), the social workers working as house parents in the Bahay Pag-Asa, and the law enforcers in the Women and Children Protection Desk (WCPD)in Baguio City Police Station 9. The members of the BCPC and the WCPD police officers were selected because they are the primary stakeholders in the handling of the cases of Children in Conflict with the Law (CICL) at the barangay level and the law enforcement level. In addition, the house parents working inside the BPA are the best source of information as they are immersed in implementing the intervention and rehabilitation programs.The challenges faced by the three duty bearers share three common themes regarding CICL: broken homes, uncooperative parents, and implementers experiencing work-related stress with the respondent coming from the WCPD experiencing mental stress. At the same time, the respondents from the BCPC experienced problems in the monitoring of repeat offenders. Lastly, the respondents from BPA experienced challenges, including handling tantrums and violations of the residents.As to the strategies used by the three duty bearers in handling the challenges and combating stress, they have commonalities. Specifically, the law enforcer from the WCPD identified support of the family as a helping factor in law enforcement involving CICL while the members of the BCPC identified maximum tolerance and continuous monitoring of the CICL as their strategy. On the other hand, the house parent from the BPA takes care of the residents like his or her own children as well as being flexible in the implementing consequences.
EFFECT OF SELF EFFICACY ON ORGANIZATIONAL PRODUCTIVITY: A RELIABILITY STUDY
Authors: Chakroborty Malabika , Guha Sriparna
Published: August 2023

This exploratory study examined the productivity of employees and effect of positive self- efficacy on productivity. Self-efficacy is measured here in terms of the concepts of presenteeism and absenteeism. Self-efficacy was examined as a positive psychological construct and was compared to the negative impact of presenters and absenteeism. This paper utilized a cross sectional questionnaire to conduct purposive sampling on 20 employees from manufacturing and service sectors in the state of west Bengal. The anonymous questionnaire contained eighteen close ended questions to avoid subjective error. Analysis wasconducted on these data as a pilot study to check the reliability of the questionnaire using Cronbachs Alpha.
THE HIDDEN CULPRIT: CHRONIC CONSTRICTIVE PERICARDITIS UNVEILING PULMONARY HYPERTENSION - A CASE REPORT
Authors:   Cardiology Department CHU IBN ROCHD., Ammouri Z. , Moussaoui S. ,   Radiology department CHU IBN ROCHD., Belkouchia S. ,   Cardiology Department CHU IBN ROCHD., Rochd M. ,   Cardiology Department CHU IBN ROCHD., Haboub M. ,   Cardiology Department CHU IBN ROCHD., Arous S. ,   Cardiology Department CHU IBN ROCHD., Benouna MG. ,   Cardiology Department CHU IBN ROCHD., Drighil A. ,   Cardiology Department CHU IBN ROCHD., Habbal R. ,   Cardiology Department CHU IBN ROCHD.
Published: August 2023

A rare illness known as chronic constrictive pericarditis (CCP) causes the pericardium to thicken and fibrose, which restricts heart function. On the other hand, pulmonary hypertension (PH) is a chronic condition marked by increased pulmonary arterial pressure and pulmonary vascular resistance that eventually results in right ventricular failure and mortality. Due to the non-specific clinical presentation of CCP and PH, it can be simple to ignore this rare and difficult diagnosis. Here, we provide a case study of a 47-year-old woman who experienced severe dyspnea and had previously experienced three miscarriages, the most recent of which had happened two months before her presentation. The patient was identified as having CCP and PH after a thorough evaluation and inquiry. This case study seeks to highlight the importance of a high index of suspicion for CCP and PH in patients presenting with dyspnea and a history of pregnancy-related complications. Our case report emphasizes the significance of taking chronic constrictive pericarditis into account in individuals who have right ventricular failure and unexplained dyspnea. Early detection and quick pericardiectomy treatment can significantly improve symptoms and outcomes. To manage cardiovascular risk factors and keep an eye out for any potential recurrence of symptoms, long-term follow-up is required.
Therapeutic Approaches for the Treatment of Interstitial Lung Disease:
An Exploratory Review on Molecular Mechanisms
Authors: Amin Revati , Pandey Ruchi , Vaishali K. , Acharya Vishak , Sinha Mukesh Kumar , Kumar Nitesh
Published: August 2023

Background:

Interstitial Lung Diseases (ILDs) are characterized by shortness of breath
caused by alveolar wall inflammation and/or fibrosis.

Objective:

Our review aims to study the depth of various variants of ILD, diagnostic procedures,
pathophysiology, molecular dysfunction and regulation, subject and objective assessment techniques,
pharmacological intervention, exercise training and various modes of delivery for rehabilitation.

Method:

Articles are reviewed from PubMed and Scopus and search engines.

Results:

ILD is a rapidly progressing disease with a high mortality rate. Each variant has its own set
of causal agents and expression patterns. Patients often find it challenging to self-manage due to persistent
symptoms and a rapid rate of worsening. The present review elaborated on the pathophysiology,
risk factors, molecular mechanisms, diagnostics, and therapeutic approaches for ILD will guide
future requirements in the quest for innovative and tailored ILD therapies at the molecular and cellular
levels.

Conclusion:

The review highlights the rationale for conventional and novel therapeutic approaches
for better management of ILD.
Role of Flexible Bronchoscopy using Biopsy Forceps as the Initial Attempt for Headscarf Pin Aspiration Extraction
Authors: Elhidsi Mia , Soehardiman Dicky , Aniwidyaningsih Wahju , Alatas Mochamad Fahmi , Desianti Ginanjar Arum , Pradono Prasenohadi
Published: August 2023

Introduction:

Flexible bronchoscopy is a less invasive procedure for extracting foreign bodies from the airways. However, studies on the extraction of headscarf pins are still very limited to determine the efficacy and safety of headscarf pin extraction using flexible bronchoscopy with biopsy forceps.

Methods:

This retrospective study was conducted at Persahabatan Hospital, Jakarta, Indonesia, on patients who had been treated in this hospital for headscarf pin extraction between January 2013 and February 2023. Fibreoptic bronchoscopy was performed under general anaesthesia. The pin was removed using Radial Jaw 4 mm single-use pulmonary biopsy forceps. The impacted sharp tip of the pin was freed first, and the proximal part of the pin body was gripped using biopsy forceps. Once a firm hold of the sharp end or the proximal part of the pin was secured, the bronchoscope and forceps were both slowly withdrawn under direct vision.

Results:

Thirty-two cases with headscarf pin aspiration were managed by fibreoptic bronchoscopy. A total of 12 patients (37.5%) came without any respiratory complaints; however, an equal number complained of cough and 6 cases (18.7%) of haemoptysis. All the cases in which the pins were visible in the airway were found with the round head down and the sharp tip oriented superiorly in the airway and impacted in the mucosa. Fibreoptic bronchoscopy extraction succeeded in 31 cases (96.8%). Only one case was converted to surgery. There were no major complications.

Conclusion:

Fibreoptic bronchoscopy with biopsy forceps under general anaesthesia is safe and effective for the removal of headscarf pin aspiration.
Hesperidin: Diversified Prospects of Naturally Occurring Bioflavonoid
Authors: Pal Rashmi Saxena , Pal Yogendra , Punniyakotti Saranya , Katiyar Deepti , Kumari Pooja
Published: August 2023

Hesperidin is one of the most well-known, naturally occurring flavonoids with antioxidant and
anti-inflammatory effect, occurring in high concentrations in citrus fruits. Citrus fruits and juices are
widely consumed worldwide and are readily available dietary sources for their intake. Its use has been
associated with a great number of health benefits, including antioxidant, antibacterial, antimicrobial, antiinflammatory
and anti-carcinogenic properties. Due to its biological activities, hesperidin is often used in
the food, cosmetic and pharmaceutical industries. Supplements containing hesperidin, alone or in combination
with other citrus bioflavonoids, are commercially available. The utilization of hesperidin can be
used for the production of novel nutraceuticals or for the improvement of older ones. This piece of review
aims to discuss the various diversified aspects of the naturally occurring bioflavonoid hesperidin.
A Comparative Clinico-Pathological Study on CRP Positive Patients W.S.R. to Amavata (Rheumatoid Arthritis) and it’s Management with Vatari Guggulu and Pathyadi Churna
Authors: Quazi Dr. Mohammed Faisal
Published: August 2023

Abstract: Introduction- C-Reactive Protein (CRP) is an acute-phase of inflammatory protein, a highly conserved plasma protein that is named for its reaction with the capsular C-polysaccharide of Pneumococcus. 1 It is an Annular (Ringshaped) Pentameric protein found in blood plasma, whose circulating concentration rise in response to inflammation and of hepatic origin that increases interleukin-6 secretion by macrophages and T-cells.2 Due to this type of inflammatory changes there are stiffness, Pain, Swelling of joints along with generalized symptoms of fever etc. present in the disease like Amavata (Rheumatoid Arthritis). Materials and methods- 30 patients of Group-A (15) and Group-B (15) patients were registered from OPD and IPD of Govt. Ayurvedic College & Hospital, Balangir presented with Subjective Parameter as Sandhi Ruja, Sandhi Shotha, Sandhi Stabdhata, Jwara, Aruchi and Daurbalya and Objective Parameter as CRP>6mg/L, ESR, Hb%, DLC,TLC and Lipid profile test. After diagnosis they were under trial with Ayurvedic formulations of Vatari guggulu given 500mg thrice daily after food in Group A and Pathyadi Churna given 5gm twice daily after food with ushnajala for a period of 30 days with respectively. The subjective and objective parameters were assessed in 10 days interval to interpret the result by statistical evaluation. Observation and results:- It has been observed that the result of trial drug Group-A patients is Significant (p<0.05) to reduce both Subjective and Objective parameter after 30 days of treatment as campair to Group-B patients.
Numerical and Experimental Investigation on the Structural Behavior of Laterally Restrained Cold Formed Steel Built-Up Sigma Section
Authors: Kamal P. , Sivagami M. , Thenmozhi Dr. R.
Published: August 2023

Abstract: This study focused on the structural behavior of laterally restrained Cold Formed Steel (CFS) built up Beam composed of two Sigma Section which are placed back-to-back with varying thickness, aspect ratio and yield stress. It’s aimed to create accurate Finite Element Model for CFS built up I beam. The numerical model was developed by using Finite Element (FE) software ABAQUS 6.13. The numerical investigation was checked and validated with help of experimental investigation. The load carrying capacity increases with increase in height and the thickness of the specimen. The specific strength decreases with increase in the height of the specimen. The specific strength of the specimen increases with increases in thickness.
Trace detection of canine distemper virus based on Michelson-interferometer sensing probe
Authors: Feng Wenlin , Zhang Xinyu , Hou Xiangyu
Published: August 2023

A single-mode-fiber (SMF)-multimode-fiber (MMF)-tri-core-fiber (TCF)
Michelson probe structure is proposed for trace detection of canine
distemper virus (CDV). One end of the TCF is cut flat and fused with the
multimode fiber, and the other end is coated with a silver film to
enhance the reflection, and an optic-fiber sensing probe with
SMF-MMF-TCF structure is obtained. The (PDDA/PSS)
multilayer film is modified on the surface of the fiber by
layer-by-layer self-assembly method as a polyelectrolyte binder to
immobilize CDV antibodies to form a (PDDA/PSS) /CDV
antibody composite membrane for specific detection of CDV antigens. The
response-recovery test of the sensor is performed to verify its
repeatability. The detection limit, the sensitivity, and the linear
fitting degree for CDV antigen are 0.1236 pg/ml, 1.1776 dB/(pg/ml), and
0.9899, respectively. At the same time, the stability, selectivity, and
clinical samples of the sensors were also verified.
Fracture prediction in flat PMMA notched specimens under tension - effectiveness of the equivalent material concept and fictitious material concept
Authors: Bura Elżbieta , Torabi Ali Reza , Seweryn A.
Published: August 2023

The fracture of notched elements under mode I loading (tension) is still
an inexhaustible research topic, especially when it comes to the
fracture of thermoplastic materials such as Polymethylmethacrylate
(PMMA), which experience large plastic strains. The paper points out
that traditional brittle fracture criteria such as Mean stress (MS) or
Maximum tangential stress (MTS) criteria used to predict this phenomenon
do not accurately indicate the value of the critical load. They work
much better when combined with the Equivalent material concept (EMC) and
Fictious material concept (FMC). While pointing out that the
effectiveness of both concepts depends on the size of the notch root
radius and thus the size of the yield zone.
Effective Area Acquisition Algorithm Based on Traditional Scanning Method
Authors: Meng Qingyu , Piao Yan , Sun Ning , Ding Xue
Published: August 2023

fisheye lens has the advantages of short focal length and wide field of
vision, and is widely used in medical applications, road traffic,
national defense and military and other occasions. This paper addresses
the effective error of the fish hole and the long extraction time in the
process of lens correction. An effective area acquisition algorithm for
edge detection and circular scanning is proposed. First of fisheye image
candy edge detection, then use fuzzy threshold method for binary image
segmentation, finally combined with the edge detection for radius and
the center trajectory diagram, to find the black pixels as the medium,
determine the position of the boundary point of an effective area, and
then gradually determine the effective area with the legal, regional
growth method and traditional linear scanning method, the results show
that the algorithm compared with the traditional algorithm of fish eye
effective area acquisition, center coordinates and radius error are
reduced. Keywords：fisheye lens、distortion、effective area
extraction、edge detection
Geophysical transect reveals seismic P-wave velocity structure of the northern Hikurangi margin, New Zealand
Authors: Luckie Thomas W , Okaya David A. , Jacobs Katrina , Henrys Stuart , Gase Andrew , Bassett Dan , Avendonk Harm J.A. Van , White Malcolm C.A. , Barker Daniel Hugh Njal , Bangs Nathan , Kodaira Shuichi , Arai Ryuta , Fujie Gou , Yamamoto Yojiro
Published: August 2023

Most conceptual models for how fluids and sediment influence slip
behavior and uplift along subduction margins are poorly constrained by
geophysical observations. Given the complexity of subduction systems,
overcoming this gap in knowledge will require a systems-level approach
which uses high quality geophysical constraints. We present wide-angle,
onshore-offshore seismic data collected along the northern Hikurangi
margin, New Zealand, from which P-wave velocities were calculated using
active- and passive-sources. A gravity model and reflection profiles
were also assembled to create a complete, ~400 km long
transect which images the incoming plate, down going slab, overthrusting
forearc, and backarc rift. Velocities and gravity modelling help to
constrain the lithology of the forearc basement to ~20
km depth. Upper plate lower crustal velocities and reflectivity point to
the presence of underplated sediments immediately above the lithospheric
mantle nose, suggesting that underplated sediments are driving uplift of
the forearc. Comparing these results to geophysical images from the
southern Hikurangi margin, we suggest that the backarc rift influences
along-strike changes in the compressional stresses experienced by the
forearc, driving changes in bending stresses within the subducting slab.
Lightweight joint inversion of point-source moment-tensor and station-specific time shifts
Authors: Pham Thanh-Son
Published: August 2023

The misalignment of the observation and predicted waveforms in regional
moment tensor inversion is mainly due to seismic models’ incomplete
representation of the Earth’s heterogeneities. Current moment tensor
inversion techniques, allowing station-specific time shifts to account
for the model error, are computationally expensive. Here, we propose a
lightweight method to jointly invert moment-tensor parameters and
unknown station-specific time shifts utilizing the modern
functionalities in deep learning frameworks. A $L_2^2$ misfit
function between predicted synthetic and time-shifted observed
seismograms is defined in the spectral domain, which is differentiable
to all unknowns. The inverse problem is solved by minimizing the misfit
function with a gradient descent algorithm. The method’s feasibility,
robustness, and scalability are demonstrated on earthquakes in the Long
Valley Caldera, California. This work presents an example of fresh
opportunities to apply advanced computational infrastructures developed
in deep learning to geophysical problems.
Unravelling the kinematics of the Brewer-Dobson circulation change
Authors: Šácha Petr , Zajíček Radek , Kuchar Ales , Eichinger Roland , Pisoft Petr , Rieder Harald Erich
Published: August 2023

Climate models robustly project acceleration of the Brewer-Dobson
circulation (BDC) in response to climate change. However, the BDC trends
derived from comprehensive models do not fully match observations.
Additionally, the changing structure of the troposphere and stratosphere
has received increasing attention in recent years and to which extent
vertical shifts of the circulation are driving the acceleration is under
debate. In this study, we present a novel method that enables the
attribution of circulation changes to individual kinematic factors.
Using this method allows to study the advective BDC trends in
unprecedented detail and sheds new light into discrepancies between
different datasets (reanalyses and models) at the tropopause and in the
lower stratosphere. Our findings provide insights into the reliability
of model projections of BDC changes and offer new possibilities for
observational constraints.
The Effect of Incorporating Vertical Spatial Variability on the Probabilistic Analysis of a Deep Excavation: A Case Study
Authors: KORKUT Dursun Enes , AKBAŞ Sami Oğuzhan
Published: August 2023

This study explores the impact of including the vertical spatial variability in effective stress friction angle of clay on the probabilistic analysis of deep excavations. The proposed methodology is demonstrated and verified by conducting random finite element modeling (RFEM) of an instrumented deep excavation project situated in Ankara, Turkey. The excavation has a depth of 20 meters and is supported by six levels of pre-stressed ground anchors. To simulate the vertical spatial variability of effective stress friction angle in the clay, Monte Carlo simulation method and the random field theory are employed. The simulated parameters are then inserted into the finite element model via Python programming language to analyze the probabilistic distribution of lateral deflections and bending moments in the drilled shaft wall. The results obtained from the Monte Carlo simulations reveal that the incorporation and selected value of spatial variability significantly impacts the resulting lateral movements, bending moments, and the probability of failure of the system.
Las Huertas con Plantas Medicinales como estrategia para el Fortalecimiento de los Resultados de Aprendizaje en la Granja Experimental Corhuila: Sistematización de la Experiencia
Authors: Fernández Toro Lili Estefani , Bonilla Cuspian Santiago , Palencia Fajardo Ofelia , Saavedra Mora David
Published: August 2023

Los resultados de aprendizaje permiten comprobar y medir la formación de los estudiantes. En las instituciones de educación superior generar rúbricas y métodos de autoevaluación garantiza la calidad de los programas de formación. El objetivo de esta investigación fue sistematizar la experiencia de trabajo con semillero de investigación y especialmente la huerta como una infraestructura donde los estudiantes pueden aplicar el conocimiento aprendido en clase. La metodología que se llevó fue una sistematización de la experiencia desde el docente, los semilleros de investigación y el trabajo en el establecimiento de una huerta de plantas medicinales. Como resultado se obtuvo que la huerta se convierte en una infraestructura donde los estudiantes pueden aplicar el conocimiento teórico, pero a su vez un indicador de resultados de investigación.
Human Rights and Identification of Human Skeletal Remains by Digital Skull-Photographic Comparisons in Uruguay
Authors: Solla Horacio E
Published: August 2023

Scientists make unique contributions in human rights cases by applying scientific and forensic techniques to criminal investigations. In human rights cases, evidence is often based solely on the oral testimonies of victims or witnesses. There is little doubt concerning the importance of oral testimonies. However, spoken evidence is much more effective when it is corroborated by physical evidence. In Latin America countries, experts such as forensic anthropologists, pathologists, and archaeologists contribute to human rights cases by aiding in death investigations and in the identification of victims remains. Forensic anthropologists are often called on for cases in which trauma analysis and identification of human skeletal remains is necessary. After 1984, Argentina, Chile and Guatemala have developed national forensic anthropology teams but they are not part of their judicial system as they are not governmental organizations. But, since 1992 in Uruguay, there is an official Forensic Anthropology Laboratory integrated to the judicial system directed by the author. Since 1992 at the present, this Laboratory has made more than 1700 official forensic anthropology report of cases and identified more than 200 people with ages ranging from 5 to 90 years old at time of death using traditional forensic anthropology techniques.
Forensic Aspects of Zolpidem Use
Authors: Soltaninejad Kambiz
Published: August 2023

Zolpidem is one of the most commonly prescribed hypnotic drugs for short-term treatment of insomnia. Zolpidem use or abuse was associated with an increased risk of driving accidents, inducing of suicide attempts and death. Its use or abuse associate with hallucinations and bizarre behaviors. Zolpidem induces anterograde amnesia, confusion and sedation and abused as a tool in drug-facilitated crimes. From this view, its analysis and interpretation in forensic cases has been important. In this article, we reviewed the some forensic aspects of zolpidem use or abuse.
New Scientific Limits for Carrying Out Personal Recognition in Crim-Inal Investigations: Unrepeatable Recognition and Requirement of Well-Founded Suspicion to Carry Out the Recognition Procedure
Authors: Pessoa Jonathan Dantas
Published: August 2023

The recognition of people is a means of proof widely used in the practice of Brazilian criminal investigations, and the inadequate application of this instrument has been a source of serious judicial errors, requiring the help of knowledge from the psychology of testimony to improve this means of evidence. In this article, some peculiarities of this investigative procedure were discussed which, once understood, will make it possible to improve the accuracy of this means of proof, being verified based on bibliographical research the uniqueness of the recognition procedure and the need for a minimum of previous elements of proof to be verified. provide this means of proof (need for well-founded suspicion), demonstrating that the diligence of recognition, as it is extremely suggestive, must be handled only once during the investigation, and that only after obtaining minimal evidence that links the suspect in the alignment with the crime being investigated, with a view to making the aforementioned procedure safer and avoiding the greater occurrence of judicial errors in the handling of this investigative technique.
Economic Analysis for Yield and Carrying Capacity of Intercropped Indigofera (Indigofera zollingeriana) and Brahum (Brachiaria humidicola)
Authors: Lumy Tilly FD
Published: August 2023

Through efficient asset management, blended societies can boost plant growth and yield. The explanation of this consider was to choose the reach similar extent of the got crops leguminosae Indigofera zollingeriana (Iz) and the tropical grass Brachiaria humicola (Bh). The explanation of this contemplate was to study the show up tantamount extent of this got alter in view of abandon and bearing limit. This test was carried out with a plan that was completely random, and it used a combination of four drugs from the planted area as follows: We used the ANOVA and HSD test to analyze the data for combination planted (C): C1, Iz planted range, which had 1.0 mx 1.0 m and Bh planted zone, which had 0.5 m x 0.25 m; C2, Iz planted range, which had 1.0 mx 1.0 m and Bh planted zone, which had 0.5 m x 0.5 m: C3, Iz planted range, which had 1.0 mx 1.5 m and Bh planted zone, which had 0.5 m x 0.25 m; C4, Iz planted range, which had 1.0 mx 1.5 m and Bh planted zone, which had 0.5 m x 0.5 m. The elements estimated were the expected acquiescence and conveying limit in view of dry matter and carrying capacity acquiescence for logical financial. The results appeared to be essentially different (P<0.01). The improved grain yields of intercrop in C3 have highest the total grain yield, carrying capacity and the net-income. Overall, these findings imply that following the optimum grain yields, and competitive interactions of intercrop species can be improved. It very well may be reasoned that Iz covered crops with an established area of 1.0 m x 1.5 m and Bh with an establishing area of 0.5 m x 0.25 m have the most fitting financial of yield and conveying limit.