bluuebunny/crossref_metadata_2025 huggingface dataset:
OPTIMALISASI LATIHAN PERANG LAWAN GERILYA TARUNA KORPS MARINIR UNTUK MENINGKATKAN KEMAMPUAN PENANGULANGAN SEPARATISME
Authors: Farhan Farhan Zulfarino Athallah , Agus Agus Suprapto , Moestin Moestin Adi Puji P , Paniai Paniai Wijaya
Published: May 2023

Korps Marinir merupakan salah satu Komando Utama Operasi (Kotama Ops) TNI di bawah komando langsung Panglima TNI. Dalam perjalanan sejarah, Korps Marinir telah menunjukkan kepada bangsa Indonesia kemampuannya sebagai pasukan pendarat amfibi.Untuk menunjang tugas pokok tersebut Korps Marinir membutuhkan pemimpin yang memiliki kemampuan serta kecakapan dalam melaksanakan tugas. Dalam hal ini Akademi Angkatan Laut sebagai lembaga yang memiliki fungsi membentuk calon calon perwira TNI Angkatan Laut termasuk calon perwira TNI Korps Marinir yang kelak nanti akan menjadi pemimpin Korps Marinir. Taruna Korps Marinir dituntut untuk dapat memahami materi di bidang militer taktik, salah satunya mengenai Taktik Kondisi Tertentu yakni perang lawan gerilya. Permasalahan dalam penelitian ini yakni kurangnya jumlah pelatih dan pendukung dalam pelaksanaan latihan, kurangnya sarana dan prasarana dan kurangnya materi yang diterima oleh taruna. Metode yang digunakan dalam penelitian ini adalah kualitatif dengan teori manajemen sebagai pedoman. Tujuan dari penelitian ini adalah untuk mengoptimalisasi latihan perang lawan gerilya dengan tujuan meningkatkan kemampuan penanggulangan separatisme taruna korps marinir sehingga setelah lulus Pendidikan akan menjadi danton yang siap ditugaskan untuk menanggulangi Gerakan separatisme bersenjata. Berdasarkan analisis yang telah dilakukan hal-hal yang perlu dioptimalkan antara lain penambahan jumlah pelatih dan pendukung, pembaruan sarana dan prasarana, penggunaan teknologi modern dalam pelaksanaan latihan dan pembentukan mata kuliah sendiri operasi perang lawan gerilya. Hasil dari penelitian ini adalah meningkatnya kemampuan penanggulangan separatisme Taruna Korps Marinir
Inovasi Sistem Pembelajaran Matematika pada Masa Pandemi Covid 19 di MTs Al-Fajar Kandat Kediri
Authors: Nisa Mahda Sofiyana Khoirun , Agustinayanti Agustinayanti , Ma’sum Muhammad Asrori
Published: May 2023

The purpose of this study was to determine the learning system used in mathematics subjects at MTs Al – Fajar Kandat and to obtain related information experienced by students in learning mathematics during the covid-19 pandemic. The COVID-19 pandemic has had an impact on the progress of the education sector. Therefore, teachers and schools can choose learning media that are easy to reach by students. The method used in this research is qualitative. The data was obtained from the results of an interview with a 9C grade student at MTs Al – Fajar. The results of this study are the learning system for mathematics subjects at MTs Al - Fajar Kandat using two systems, the first is a daring learning system, in which the teacher provides material by sending a You Tube link and sending assignments to the Whats App Group. Then to collect assignments via private chat to the math teacher via Whats App. Constraints experienced by students in bold learning are the lack of understanding of the material presented and students are still confused with the material. The second learning system is the offline learning system, in this system it is only carried out when there is a Mid-Semester Examination and a Final Semester Examination. In this system students carry out face-to-face exam activities using the question sheet provided by the teacher. Due to a lack of understanding when learning to be brave, the impact experienced by students in learning to be brave is that the student's grades go down.
Análise de Redes de 4.500 casos do Inventário de Sintomas de Stress de Lipp
Authors: Vieira dos Reis Alessandro , Moraes Cruz Roberto , Sant´Ana Rabelo Ivan , Leme Irene , Lipp Marilda , Anunciação Luis
Published: May 2023

O estresse é um estado psicofisiológico de desgaste central no campo da saúde e da psicopatologia. Sintomas de diversos transtornos mentais, incluindo ansiedade e depressão, integram-se aos quadros clínicos de estresse de maneira complexa. Este estudo tem por propósito analisar os sintomas de estresse com base no método da Análise de Redes (AdR) utilizando para isso os dados da pesquisa de revisão dos índices de validade, precisão e atualização de normas do Inventário de Sintomas de Stress para adultos de Lipp. Foram analisados dados de 4.500 participantes da população brasileira para estabelecer a topografia da rede, seus índices de centralidade e de estabilidade. Os resultados indicaram uma rede estável, com correlações moderadas entre os 53 sintomas em 3 categorias, conforme previsto, sem apresentar clusters isolados de sintomas. Em termos de centralidade, um grupo de cinco nodos parecem indicar os sintomas decisivos para um diagnóstico de estresse. O índice de estabilidade dos vértices da rede indicou uma rede bastante estável (0.75/1). O que foi confirmado pelos índices de Correlação, Sensibilidade e Escassez (todos > 0.8/1); e pela estabilidade dos índices de centralidade que se mantêm bons mesmo com apenas 40% da amostra utilizada. Os resultados indicam um padrão estável de sintomas de estresse aplicál para uma avaliação psicológica com maior validade psicométrica.
Interdição e medicalização de pessoas com transtornos mentais: estudo de caso do documentário Britney X Spears
Authors: Coser Milena Ísis , Da Rocha Camargo Maria Eduarda , Müller Lourenço Gabriela , Menegatti Claudia Lúcia
Published: May 2023

O presente artigo discutiu os temas da interdição legal, sobretudo o processo da curatela, e medicalização de pessoas com transtornos mentais, a partir do estudo de caso do documentário Britney X Spears (Carr, 2021). As reflexões propostas trouxeram o tema da influência dos valores pós-modernos, como o individualismo. Neste cenário, por meio do foco em ideais como produtividade e alta responsabilidade atribuídas ao indivíduo por suas escolhas, a lógica pós-moderna afeta também o campo médico e jurídico da sociedade. O trabalho objetivou refletir sobre as consequências subjetivas dos processos de interdição legal e da medicalização da vida em pessoas com transtornos mentais e sua correlação à sociedade pós-moderna, ao investigar suas manifestações a partir dos dados expostos no longa-metragem. O método utilizado para o estudo de caso do material foi a análise documental comparada à literatura. Os resultados obtidos apontam para a interdição e medicalização, apoiadas na judicialização da saúde, como processos vinculados ao contexto pós-moderno. Ambos os fenômenos estudados desempenham papéis reforçadores dos estigmas relacionados às psicopatologias, como consequência do reducionismo biologicista - pela perspectiva biomédica - e do reducionismo de causalidade - pelo âmbito jurídico. A percepção de pessoas com transtornos mentais associadas à incapacidade, na interdição e na medicalização, foi explorada a partir do que foi exibido no documentário sobre a artista Britney Jean Spears. Conclui-se que, no contexto pós-moderno, comportamentos geradores de sofrimento psíquico são reforçados pela atuação biomédica e jurídica, ao mesmo tempo que esses reproduzem estereótipos das psicopatologias por mecanismos de poder.
Violências sofridas e dirigidas às pessoas diagnosticadas com transtorno psíquico: uma revisão integrativa
Authors: Vitali Marieli Mezari , Leandro Maiara , Giacomozzi Andréia Isabel , Bousfield Andréa Barbará da Silva
Published: May 2023

O objetivo do presente estudo foi caracterizar as violências sofridas e dirigidas a pessoas diagnosticadas com transtornos psíquicos a partir de uma revisão integrativa de literatura. As buscas foram realizadas em 5 bases de dados: SciELO, Pepsic, LILACS, SCOPUS e Web of Science; os critérios para seleção dos estudos foram: artigos científicos publicados entre 2010 e 2020, e que respondessem ao objetivo do estudo. Foram inseridos 41 artigos na presente revisão e a análise de conteúdo permitiu a identificação de 5 categorias associadas ao fenômeno investigado: violência sofrida, fatores associados à vitimização, quem pratica a violência, formas de lidar com a violência e local em que ocorre. Identificou-se um fenômeno múltiplo e complexo, associado ao estigma da “loucura”, que deve ser debatido e visibilizado.
The social representation and social action effect of critical issues: autonomic system and self-report measures
Authors: Acconito Carlotta , Angioletti Laura , Balconi Michela
Published: May 2023

By combining words and images that impact emotions and generate empathetic storytelling, advertising (ADV) has evolved into a form of communication for promoting consumer awareness, positive social change, and ADV-related decisional processes, even on topics of high-social relevance such as crisis communication. This study explored consumers’ emotional and cognitive responses to crisis-related ADVs using implicit (autonomic) and explicit (self-report) measurements. Nineteen participants watched twelve high-impact social communications about Covid-19, personal health, safety, and prosociality, while autonomic and self-report data were collected. Personal health, safety, and prosociality had higher skin conductance than Covid-19 stimuli, indicating higher arousal and engagement. Personal health reported lower heart rate variability values than Covid-19, suggesting greater emotional reactions for personal health topics, but also lesser mental load for Covid-19 stimuli. Self-report results confirmed autonomic findings. In conclusion, communications about personal health, safety, and prosociality generate higher emotional impact and allow for effective storytelling that facilitates viewer identification, developing a high level of empathy.
Assessing decision-making skills: preliminary proof-of-concept data for DAssDec - Mod1STY and Mod2STR
Authors: Crivelli Davide
Published: May 2023

From a psychological and neuroscientific perspectives, decision-making can be defined as a skill, a function and/or a process we pervasively implement in our everyday life. Embracing a definition of decision-making that describes it as a multicomponential, pervasive, and instrumental ability, the Digitalized Assessment Tool for Decision-Making (DAssDec) – a novel digitalized assessment tool – has been devised with the specific purpose to capture the multifaceted nature of decision-making and to sketch an articulated profile of its many dispositional and situational manifestations. We here introduce preliminary outcomes from proof-of concept and feasibility study performed on the first two domains of the DAssDec Tool – Mod1STY and Mod2STR – dedicated to decisional styles and strategies. 35 professionals working in managerial departments of a large service company took part in the study. Findings pointed out the feasibility, usability, and practical value of the investigated sections of the DAssDec tool. Also, first quali-quantitative analyses of participants responses and performance at the tasks included in the tested domains have already highlighted the potential of the tool to detect interindividual differences, thus pairing the opportunity to outline a global profile of a work team with specific individual profiles of decision-making skills and their subjective determinants.
Imaginario social desde las expresiones gráficas en ambientes público-privados del centro de Bogotá
Authors: García Martínez Omar Alonso , Portilla Benítez Yubar Deibi
Published: May 2023

Imaginario social desde las expresiones gráficas en ambientes público-privados del centro de Bogotá, es una serie de especulaciones ornamentales de tres lugares públicos y privados del centro de Bogotá, Colombia. Es un documento mediado por la historia y las relaciones estéticas que se presentan en el Café Pasaje, la Cervecería Luna Park y el bar de Doña Ceci; lugares que por décadas se han establecido como espacios culturales, sociales e intelectuales de la ciudad.
Plantar Vein Thrombosis in a Patient with COVID-19: Case Report
Authors: Bernardo Bruno de Souza , Pagnano Rodrigo Gonçalves , Filho Miguel Viana Pereira , Freitas Marcio de Faria , Dinato Mauro Cesar Mattos e
Published: May 2023

Plantar thrombophlebitis is a rare abnormality with few cases reported in the literature. Coexistence with severe acute respiratory syndrome coronavirus 2 infection increases its relevance. The disease is generally classified as idiopathic, and it is suggested that it is attributed to conditions that lead to hypercoagulability. We present the case of a 68-year-old female patient with thrombosis of the lateral plantar veins and a diagnosis of coronavirus disease of 2019. The plantar vein thrombosis diagnosis was made by means of Doppler ultrasonography and magnetic resonance imaging. Severe acute respiratory syndrome coronavirus 2 infection was suspected per clinical information and confirmed with reverse-transcriptase polymerase chain reaction technique. Treatment was successful using rivaroxaban and nonsteroidal antiinflammatory drugs.
CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment
Authors: Muthana Musleh M , Du Xuexiang , Liu Mingyue , Wang Xu , Wu Wei , Ai Chunxia , Su Lishan , Zheng Pan , Liu Yang
Published: May 2023

Germline CTLA-4 deficiency causes severe autoimmune diseases characterized by dysregulation of Foxp3+ Tregs, hyper-activation of effector memory T cells, and variable forms autoimmune cytopenia including gradual loss of B cells. Cancer patients with severe immune-related adverse events (irAE) after receiving anti-CTLA-4/PD-1 combination immunotherapy also have markedly reduced peripheral B cells. The immunological basis for B cell loss remains unexplained. Here, we probe the decline of B cells in human CTLA-4 knock-in mice by using anti-human CTLA-4 antibody Ipilimumab conjugated to a drug payload emtansine (Anti-CTLA-4 ADC). The anti-CTLA-4 ADC-treated mice have T cell hyper-proliferation and their differentiation into effector cells which results in B cell depletion. B cell depletion is mediated by both CD4 and CD8 T cells and at least partially rescued by anti-TNF-alpha antibody. These data revealed an unexpected antagonism between T and B cells and the importance of regulatory T cells in preserving B cells.
The critical node detection problem in hypergraphs using weighted node degree centrality
Authors: Képes Tamás-Zsolt
Published: May 2023

Network analysis is an indispensable part of today’s academic field. Among the different types of networks, the more complex hypergraphs can provide an excellent challenge and new angles for analysis. This study proposes a variant of the critical node detection problem for hypergraphs using weighted node degree centrality as a form of importance metric. An analysis is done on both generated synthetic networks and real-world derived data on the topic of United States House and Senate committees, using a newly designed algorithm. The numerical results show that the combination of the critical node detection on hypergraphs with the weighted node degree centrality provides promising results and the topic is worth exploring further.
El desdibujamiento de la idea binaria legal/ilegal para la excepción mexicana
Authors: Rico Jesús Enrique Morales
Published: May 2023

El objetivo del ensayo se orienta a la interpretación teórica de la excepción mexicana, lo que ha influido en la construcción colectiva del sentimiento de inseguridad pública, derivada de la creencia que argumenta que el orden legal no funciona, sin embargo, desde ahí se interpreta la ilegalidad, lo que limita la capacidad analítica para visualizar que lo ilegal es parte de la excepción, creada por el Estado mexicano y atendida, lo que aparece como una contradicción, desde el orden legal para deslegitimar las acciones sociales informales o ilegales.
Identidade profissional e estigma: um estudo com policiais militares
Authors: Dos Santos Rodrigo Cardoso , Rodrigues Andrea Leite , De Lima Tereza Cristina Batista , Araújo Rafaela de Almeida
Published: May 2023

O estudo objetivou investigar como ocorre a construção da identidade do policial militar a partir do estigma social, baseado na teoria de Slay e Smith (2011). Esta pesquisa foi realizada mediante entrevistas semiestruturadas com 14 aspirantes a oficial da Polícia Militar e analisadas por meio de análise de conteúdo. Os resultados apontam que as influências iniciais foram de familiares policiais e pelo imaginário do policial-herói. Em relação as experiências profissionais, foi possível averiguar que o curso é um momento de transformação para a superação de seus limites e da cultura da abordagem policial violenta. A redefinição do eu ocorreu por meio da mudança de postura e desenvolvimento de responsabilidades. A redefiniçao da profissão ocorreu por meio do reconhecimento da comunidade e de seus pares. Por fim, a redefinição do estigma ocorreu por meio da compreensão da origem do estigma e assimilação da missão de servir e proteger.
Determinantes do endividamento e da inadimplência de agentes bancários de Teófilo Otoni, no Vale do Mucuri, em Minas Gerais
Authors: De Souza Alysson Alves , Brito Larissa Vermeulhe , Da Silva Edimilson Eduardo , De Souza Marcio Coutinho
Published: May 2023

O endividamento e a inadimplência são temas que se encontram em intensa análise e pesquisa na academia e fazem parte do cotidiano da população, principalmente em pequenos municípios. A literatura mostra que não são apenas os fatores socioeconômicos que apresentam impacto no nível de endividamento e inadimplência do indivíduo; outras variáveis demográficas e, principalmente, traços de personalidades, também tendem a explicar essa realidade do consumidor. Diante do exposto, o objetivo principal deste trabalho foi identificar os fatores determinantes do endividamento e da inadimplência dos bancários da cidade de Teófilo Otoni – MG. O estudo é de caráter quantitativo, por meio de uma pesquisa de campo em uma amostra de 56 indivíduos, onde as hipóteses apresentadas no modelo teórico foram baseadas no estudo de Silva, Vieira e Faia (2012). Com o intuito de atingir o objetivo utilizou-se duas técnicas multivariadas para a análise: a Análise Fatorial Exploratória e a Regressão Linear Múltipla. Os resultados do trabalho apontaram que o materialismo se constituiu como um dos fatores preditivos para o endividamento e a inadimplência. Associado a essa evidência, o autocontrole se apresentou como um inibidor da inadimplência. Esses resultados revelaram que o construto autocontrole foi um aspecto relevante, inferindo-se que o fato de poupar dinheiro, diminui consideravelmente a chance  da inadimplência.
A certificação da produção orgânica na agricultura familiar brasileira: uma análise econômica e mercadológica além do Propensity Score Matching
Authors: Froehlich Anderson Gheller , Dalfovo Wylmor Constantino Tives , Carvalho Daniela da Silva
Published: May 2023

Muitas pesquisas têm comparado a diferença do desempenho econômico de produtores agrícolas orgânicos certificados e não certificados, mas eles apresentam resultados divergentes. Alguns desses trabalhos corrigiram o viés de seleção devido às variáveis observáveis, porém, nenhum deles tratou adequadamente a questão do viés relativo às variáveis não observáveis. Neste estudo se aplica o método Propensity Score Matching para corrigir o viés das variáveis observáveis, e a técnica recentemente desenvolvida por Millimet e Tchernis (2010) para corrigir o viés que surge do não atendimento ao pressuposto da independência condicional (CIA). Foram utilizados os dados do Censo Agropecuário (IBGE, 2006) da agricultura familiar no Brasil, com 71.189 observações. Os resultados confirmaram a hipótese da pesquisa, revelando que os agricultores familiares brasileiros certificados possuem 10% a mais em sua renda e cerca de 30% a mais no lucro, além de terem maior integração com o mercado.
Práticas de gestão ambiental em uma instituição de ensino superior: um estudo de caso em uma universidade localizada no sul do Brasil
Authors: Fagundes Camila , Schreiber Dusan
Published: May 2023

A gestão ambiental apresenta-se como uma alternativa para contribuir na redução dos impactos ambientais decorrentes da ampla e, muitas vezes, incorreta utilização de recursos naturais por parte das organizações. Com isso em vista, entende-se que muitas empresas buscam certificações internacionais e/ou implantam Sistemas de Gestão Ambiental (SGA) para impactar de maneira mais eficiente seus consumidores finais, os quais, em contrapartida, adotam uma postura ambientalmente correta. Nesse sentido, o presente estudo tem como objetivo investigar as práticas de gestão ambiental em uma universidade localizada na região sul do Brasil. Para atender ao objetivo proposto, adota-se a abordagem qualitativa em um estudo de caso único de acordo com as especificidades de Yin (2015). Como resultados, evidenciam-se ações notoriamente importantes e pertinentes à busca pela sustentabilidade por parte da universidade em questão, ainda que não possua efetivamente um Sistema de Gestão Ambiental devidamente estabelecido para mitigar seus impactos negativos ao meio ambiente.
Phenotypic and Genotypic Appraisal of Pulmonary Mucinous Adenocarcinoma: A Retrospective Study
Authors: Roshan VG Deepak , Ramji Ashwini , Saravanan M , Gopinath Vipin , Nayanar Sangeetha K
Published: May 2023

Introduction: Lung cancer is the second most common cancer diagnosed in the world. According to GLOBOCAN 2020, it is approximately 11.4% of all malignancies and accounts for one in five cancer deaths worldwide. Several driver gene mutations are known in lung adenocarcinoma including Epidermal Growth Factor Receptor (EGFR), Kirsten rat sarcoma viral oncogene homolog(KRAS), v-raf murine sarcoma viral oncogene homolog B1(BRAF), Human epidermal growth factor receptor2 (HER 2), anaplastic lymphoma kinase (ALK), Ros Protooncogene 1, Receptor Tyrosine Kinase (ROS1) and rearranged during transfection (RET). Among these, KRAS mutation has been classically defined as bearing a negative prognostic factor. They are described to have unfavourable survival rates as compared with KRAS wild- type tumours. However, its real significance remains controversial due to heterogeneity amongst studies. Aim: The aim of this study was to assess the histomorphology, immunophenotype, EGFR and KRAS mutation profile in invasive mucinous and mixed mucinous/non mucinous type lung carcinoma. Materials and Methods: This retrospective study was done at a tertiary cancer centre in the state of Kerala, South India to identify the frequency of EGFR and KRAS mutations in invasive mucinous or mixed mucinous/non mucinous type lung carcinoma diagnosed during the period June 2017 to March 2019. Immunohistochemical assays for CK7, CK20, TTF-1, Napsin-A, CDX-2 and p63 were done on all cases. EGFR mutation analysis for exons 18, 19, 20, 21 were done using ARMS PCR and KRAS mutation analysis for codons 12, 13, 61, 146 by Sanger sequencer. Descriptive statistics was used wherever applicable. Results: Out of a total of 290 patients of pulmonary adenocarcinoma during the two year study period, twelve cases (4.1%) were diagnosed as invasive mucinous or mixed mucinous/non mucinous types based on histomorphology and immunophenotype, on both lung tissue biopsies as well as material from metastatic sites. Of the twelve, nine (75%) were pure mucinous and three (25%) were mixed mucinous and non mucinous. All the twelve cases were subjected to molecular testing for both EGFR and KRAS. Three cases (25%) showed KRAS mutations in codon 12. EGFR mutation (TKI resistant T790M mutation) was found only in a single case which had a histology of mixed mucinous and non mucinous carcinoma and a coexistent mutation in KRAS (c12 G>C) gene. Conclusions: Our study corroborates the described fact that pulmonary mucinous carcinoma differ from the conventional adenocarcinoma in terms of its histology, immunoprofile and molecular profile. KRAS mutation appears to be the main pathogenetic factor in this variant. In the current day practice, there is no demonstrable effective therapy for KRAS mutant lung adenocarcinoma and more trials are needed to identify newer mutations that can modify treatment outcomes.
Predictors of Severity and Mortality among Hospitalised COVID-19 Patients during First Three Waves- A Retrospective Study
Authors: Alapaty Shailaja , Dhulipala Suhas , Sirsikar Mangala N , Annavarapu Umalakshmi , Mahendrakar Deepthi , Haran Alamelu , Katare Praveen
Published: May 2023

Introduction: Coronavirus disease 2019 (COVID-19) was was a global pandemic outbreak that emerged in three waves of varying severity. The inflammatory markers can be used to identify the transition of severity of the disease from a mild to severe or critical illness and also to predict the mortality. To improve clinical outcomes, continuous monitoring of these biomarkers in hospitalised patients is essential. Aim: To compare the serum C-Reactive Protein (CRP), Lactate Dehydrogenase (LDH), serum ferritin and D-Dimer as a predictor of severity and mortality in hospitalised patients in different clinical categories during three waves of COVID-19 . Materials and Methods: This retrospective study was conducted at Vydehi Institute of Medical Sciences and Research Centre, Karnataka. A total of 6189 patient’s data were retrieved from medical record section with confirmed cases of COVID-19 admitted during the three waves of COVID-19. The results of four inflammatory marker on the day of admission were analysed in mild, moderate, severe and critically ill patients and compared with disease severity, survival and death and also assessed the difference between first, second, and third wave of COVID-19 for sensitivity and specificity. Data was analysed by Chi-square test, Mann Whitney U test, ANOVA (Analysis of Variance), and Kruskal Wallis test and Receiver Operating Curve (ROC). Results: The median age of patients in the mild category was found to be younger in all three waves compared to those in the severe and critically ill categories. In terms of gender distribution, males were more prevalent than females. Inflammatory markers were significantly increased in all three waves in the severe and critically ill categories. The median CRP (mg/dL) values were significantly increased in the critically ill in wave three compared to waves one and two. The median values of LDH IU/L significantly increased in critically ill patients in the second wave. The median values of ferritin increased significantly in wave one. The D-dimer values significantly increased in the critically ill category in wave three. Conclusion: Before proceeding on to a specific diagnosis by RT-PCR, a combination of standard laboratory markers (CRP, LDH, and Ferritin D-Dimer) could accurately and reliably predict the diagnosis of COVID-19 with established sensitivity and specificity.
Effects of Paternal Age on Semen Quality and Status of Fertility at a Tertiary Care Hospital, West Bengal, India: A Cross-sectional Study
Authors: Kayal Pritam , Banerjee Joyashree , Ray Rajarshi , Mukhopadhyay Bulbul
Published: May 2023

Introduction: Modern couples are inclined to postpone conception as a result of societal pressures and expectations during the last several decades. The impact of age on spermatogenesis in men is not much studied. While there are no known limits to the age at which men can father the children, the implications of Advanced Paternal Age (APA) are poorly understood. Aim: To assess the relationship between advancing age and aberrant sperm parameters in the male partners of sub fertile couples in West Bengal, India. Materials and Methods: This cross-sectional hospital-based study was carried out in the Department of Physiology, R.G. Kar Medical College and Hospital, West Bengal, India, from February 2020 to January 2021. A total of 56 male subjects of couples, who have been screened as subfertile, in the age group of 21-40 years were enrolled in the study. Semen analysis was done by light microscopy using a Makler counting chamber after three days of abstinence according to the World Health Organisation (WHO) 5th edition 2010 guidelines. The data was evaluated with the use of an Microsoft Excel sheet and Statistical Package for the Social Sciences (SPSS) software version 20.0 by employing a Chi-square test. Results: In the present study, the study population consisted of 56 male partners of subfertile couples with a mean age of 29.68±5.87 years. Thirty one subjects (55.4%) out of 56 subjects had abnormal semen parameters. Most common abnormality detected was asthenozoospermia (n=10, 17.9%) followed by oligoasthenozoospermia (n=9, 16.1%) and oligozoospermia (n=6, 10.7%). There was significant association of APA with aberrant semen parameters. Conclusion: While asthenozoospermia was the most common semen abnormality, oligoasthenozoospermia was mostly found among the males of higher age groups. Clinicians could advise genetic counselling and DNA fragmentation assay to potentially prevent mishaps of delayed paternity.
Root Cause Analysis of Invalid Internal Control in COVID-19 RT-PCR Testing: A Learning Experience
Authors: Krishnan K Usha , Praveena VG , Mary D Therese , Suganthi M , Madhumathy A , Ravinder Thyagarajan
Published: May 2023

Introduction: Laboratory diagnosis of Corona Virus Disease- 2019 (COVID-19) plays a major role in diagnosing and treating infection. The corner stone in strategic public health interventions and breaking the chain of transmission was diagnostic laboratory testing and case-based data. The purpose of the study was to establish quality control standards for RT-PCR testing laboratory by performing Root Cause Analysis (RCA) of invalid Internal Control (IC). Aim: The aim of the study was to estimate the percentage of invalid IC and to describe the most probable associated factors. Materials and Methods: This cross-sectional observational study was conducted at the RT-PCR laboratory in Microbiology department of Govt. Kilpauk Medical College and Hospital for a period of one month, October 2021. The nasopharyngeal and oropharyngeal swabs collected for COVID-19 testing were included in the study. A detailed check-list was prepared by the author for evaluating of invalid IC. Results: All the variables of RT-PCR test were categorised as pre-analytical, analytical and postanalytical phases and each and every component was assessed as per the protocol. Out of 23500 samples included in the study, a positive test result for COVID-19 was obtained in 164 (0.69%) and a negative result in 22533 (95.89%) patients. Around 803 (3.41%) samples included in the study showed an invalid IC. Conclusion: Current observation showed that an invalid IC could be caused by any factors starting from sample collection to reporting. Major causes for an invalid IC were due to improper extraction and sample collection.
Early Predictors of Severity in Newly Diagnosed COVID-19 Patients: A Cross-sectional study
Authors: Palaparthi Elizabeth Caroline , Ganji Suresh Babu , Nethagani Jayalatha
Published: May 2023

Introduction: Corona virus disease 2019 (COVID-19) is a pandemic that has claimed many lives and consumed financial resources globally in the recent past. In this context, it is necessary to evaluate the role of different ‘low-cost’ and routine serum biochemistry markers in predicting the severity of illness in patients with COVID-19. There are many studies are available in this regard to assist clinicians to predict the severity of COVID-19, but were from high end laboratories which include costlier markers. Aim: To study the routinely done serum biochemistry markers which are of lower cost to determine their role individually and in combination in the early prediction of on-going severity of diagnosed COVID-19 patients. Materials and Methods: This was a descriptive and cross- sectional study,conducted in Department of Biochemistry and Microbiology at Mehdi Nawaz Jung Institute of Oncology and Regional Cancer Center (MNJIO & RCC), a tertiary cancer care institute at Hyderabad, India for a period of three months during the pandemic second wave, from August to October 2021. A total of 100 subjects of 35 to 75 age group who were Reverse- Transcriptase-Polymerase Chain Reaction (RT-PCR) positive for SARS-COV2 were included in this study. At the same time of swab, venous blood collected for Lactate Dehydrogenase (LDH), Alanine Aminotransferase (ALT), Albumin, C-Reactive Protein (CRP) and Ferritin and electrolytes sodium, potassium were estimated. These subjects were followed for ten days to categorise the severity, whether home quarantined or hospitalised. The numerical data was recorded as master chart in MS Excel spread sheet, and was imported to the free trial software, IBM SPSS Statistics (version 28.0) and analysed. Results: Age and sex did not show any significance (p=0.12&0.62) but smoking, alcoholism and co-morbidities had a significant association with the level of illness (p<0.001). Serum LDH, CRP and Ferritin were qualified as significant (p<0.001) markers to predict the ongoing severity. The relationship between the LDH, Ferritin and CRP and the severity is expressed as Odds Ratios (OR) with 95% confidence intervals. The combined use as markers for these three parameters had 0.99 area under curve with a best predictive efficacy at 100% sensitivity and 80.3% specificity with positive likelihood ratio of 5.07. Conclusion: Routine chemistry parameters are cost-effective as they are readily available, of lower cost and can be used in combination and also time saving investigations helpful in predicting the need for hospitalisation so as to assure the safety of COVID-19 patients.
ROLE OF GUGGULUPANCHAPALA CHOORNAM IN MANAGING THE COMPLICATIONS OF TYPE 2 DIABETES MELLITUS: A REVIEW
Authors: SG Vipin , Moharana Pradeep Kumar , PK Arathi
Published: May 2023

Diabetes mellitus is a metabolic disorder characterised by hyperglycaemia resulting from defects in insulin secretion, insulin action or both. The disease is classified based on physiological status, mainly categorised into type 1 and type 2. Recent studies show that type 2 diabetes mellitus is being considered as being caused due to the impairment in the immune system, which has already been explored as one of the reasons causing diabetes or prameha in Ayurveda. The patients of prameha inherently carry the risk of impaired agni and depleted ojas status, that is, hypometabolic and immuno-compromised state. The primary goal is not merely to achieve normoglycemia but also to minimise its complications. In this context, many Ayurvedic drugs are undergoing extensive research. The chronic complications of diabetes are broadly divided into microvascular and macrovascular, with the former having a much higher prevalence than the latter. Microvascular complications include neuropathy, nephropathy, and retinopathy, while macrovascular complications include cardiovascular disease, stroke, and peripheral artery disease (PAD). This choornam is presumed to act as an agent to clear occlusions in the microvascular and macrovascular vessels, and this article intends to delve deeper into the mode of action of Guggulupanchapala choornam in breaking the samprapathi of prameha and its associated comorbidities. This article is an attempt to shed some light on the application of Guggulupanchapala choornam in the treatment of prameha and thereby reducing the various complications which follow it.
A PHYTOPHARMACOLOGICAL REVIEW OF CORALLARIA PARVIFOLIA LINN.
Authors: Bharathi R. Vijaya , Nandhini S. , Nithya K. , Nithyapriya R. , Tamilarasan D.
Published: May 2023

Corallaria parvifolia is a medium-sized deciduous tree up to 15 m high and is native to India and Malaysia. It is a well-known plant used in traditional medicine for its broad therapeutical activities. These uses motivated several researchers and scholars to study its chemical composition and pharmacological activities, mainly in seeds, leaves and barks. It has been planted extensively throughout the tropics as an ornamental and has become naturalised in many countries. The phytochemical screening revealed various secondary metabolites such as alkaloids, anthraquinones, tannins, flavonoids, steroids, coumarins, triterpenoids, polyphenols, saponins, polysaccharides and glycosides. Similarly, experimental studies of this plant have shown numerous pharmacological activities such as anti-inflammatory, antinociceptive, antiherpetic, antiemetic, antidiarrheal, anthelmintic, antihypertensive, antifungal, CNS depressant and anticonvulsant and proteinase inhibitor. This review summarises the stupendous therapeutic potential of Corallaria parvifolia that should be explored, opening new perspectives and approaches for future researchers and developing new products. This review will satisfy the needs of researchers for their future research activities.
A CRITICAL REVIEW OF ASHWAGANDHADI LEHA ON MALNUTRITION IN CHILDREN
Authors: Choudhary Kishan Gopal , Sinha Nitu , Ojha Nisha Kumari
Published: May 2023

Malnutrition is characterized by deficiencies, excesses, or imbalances in a person's nutrient or calorie consumption. Children in developing countries like India continue to struggle with this serious and challenging public health problem. According to India's most recent National Family Health Survey (NFHS-5), 36% of infants under five have stunted growth (too short for their age). This is an indication of ongoing malnutrition. 32% of children under five are underweight, which is a symptom of severe undernutrition, while 19 percent of children under five are wasted (too small for their height). Malnutrition can be correlated with Karshya in Ayurveda, and it can be managed with a preparation of Ashwagandha called "Ashwagandhadi Leha." This drug is made up of the following ingredients: Ashwagandha (Withania somnifera), Tila (Sesamum indicum), Mash (Vigna mungo), Guda (Jaggery), Pippali (Piper longum), and Ghrita (Cow ghee). Emphasizing "Ashwagandhadi Leha's" efficacy in treating malnourished children is the main purpose of the current review. The ingredients of this drug have Deepana (increase digestive fire), Balya (Provide strength), Brinhana (provide nourishment), and Rasayana (rejuvenator) properties. The clinical evidence shows that these health promoters enhance bioavailability and have excellent nutritional properties. The present paper reveals that this drug is better for gaining weight in malnourished children.
A COMPREHENSIVE REVIEW OF LODRYADHYA AGADA: AN AGADA FORMULATION
Authors: N Shreeraksha , Kumar Amala U , Bharati Ashwinikumar S , Hussain Gazala
Published: May 2023

Agada tantra is considered as one of the most ancient branches of Ayurveda. It is a clinical branch that deals with bites of snakes, insects, spiders, scorpions, rats, etc., their characteristic symptoms, and the signs and symptoms of accidental or purposeful ingestion of poisons. In the management of poison, various treatment procedures have been described; one among them is the use of agada formulations. Various formulations are described, which are made up of herbal, animal origin and Herbo-mineral origin. One among them is Lodryadhya agada (Herbo-mineral), which is mentioned in the treatment of sarpa visha (snake poison). It is a formulation of twenty-three drugs, and bhavana dravya are Gritha kumari, ksoudra and Gopitta (cow’s bile). This agada destroys the poison of snakes, rats etc. and cures possession by evil spirits, fevers, epilepsy, insanity due to seizures by evil spirits, abdominal tumours, indigestion and visuchika.
A CONCEPTUAL STUDY OF AMSA MARMA WITH SPECIAL REFERENCE TO FROZEN SHOULDER: A REVIEW
Authors: Gujar Pratima A. , Madavi Kishorkumar , Khanolkar Gurunath , Meshram Dnyaneshwar , Mhaisekar Jayashree
Published: May 2023

Marma is a very important concept of Ayurveda. The science of marma is a unique and outstanding Ayurvedic concept with great value. Marma is centres of vital force i.e., prana. Marma is described in Samhitas in detail with respect to its number, site, structure, traumatic effects, the predominance of Panchamahabhuta and its clinical aspect. The total number of marma is said to be 107. Acharya Sushruta has given the number of marma in different anatomical parts of the body, namely urdhva jatrugata, sakthigata, udargata, uragata, and prushthagata. The site where the integration of mamsa, sira, snayu, asthi and sandhi takes place is known as marma. These are further divided into sadya pranahara, kalantara pranahara, vishalyaghna, vaikalyakara and rujakara marma. Amsa marma is a type of prushthagata marma anatomically and vaikalyakara marma according to viddha lakshana. An injury to amsa marma causes stabdhabahuta, in which the shoulder joint gets affected and restricts arm movement. These symptoms are similar to that of avabahuka. So frozen shoulder is a painful condition of unknown cause with loss of motion of the shoulder and arm. As it is a prevalent musculoskeletal disorder, the study of amsa marma is done regarding frozen shoulder conceptually to rule out the anatomical structure affecting, and it will be helpful to find effective treatment such as marma chikitsa while treating frozen shoulder.
PHARMACOGNOSTIC AND PHARMACOLOGICAL PROPERTIES OF GAMBHARI FRUIT (GMELINA ARBOREA ROXB.): A REVIEW
Authors: Kumiya Radhika , Singh DC , Kavya GM , Vashisht Kiran
Published: May 2023

Gmelina arborea Roxb. is one of the famous medicinal plants of the family Lamiaceae, which different Ayurvedic physicians widely prescribed as a drug of choice for treating many diseases. This drug is commonly named “Kashmarya” and is one of the popular medicinal plants mentioned in all classical textbooks of Ayurveda. It is also known as “Gambhari” because of its fast-growing property, and it is a widely propagated and cultivated tree that grows throughout India. In the Dashamoola groups of herbs, Gambhari (Gmelina arborea Roxb) is one of the components. In Ayurvedic classical textbooks, different plant parts, like roots, fruit, leaf, flower, and bark, can be used medicinally. The edible fruits of Gambhari bear rejuvenating, brain tonic and aphrodisiac qualities. The leaf of Gambhari has been mentioned in the diseases like vrana (wounds) and Kushtha (Skin diseases). The classical part of the plant Gambhari is the root. The present article provides insight into the literature review of the Gambhari fruit. The current manuscript compiles extensive information about Gambhari (Gmelina arborea Roxb.) fruit which is well-mentioned in most Ayurvedic classics textbooks like Brihatrayee, Laghutree and Nighantu.
GRAHANIBEELU (LEUCAS BIFLORA [VAHL] R. BR) AN EXTRA PHARMACOPEIAL DRUG OF AYURVEDA: AN OVERVIEW
Authors: Mayakar Pratibha Irappa , Jartarghar Nagaratna S. , S Ravikrishna , . Chithralekha
Published: May 2023

Nature is nurture. Since time immemorial, Folk medicines have been the traditional beliefs of our ancestors to protect their health with the help of herbal and other remedies; like Ayurveda, folk medicines serve both preventive and curative purposes. One such medicine is Grahanibeelu
NEED OF SHARADI VIRECHANA: A CONCEPTUAL REVIEW
Authors: George Jelin , Acharya Yogeesha , Kumar Sandesh
Published: May 2023

A healthy lifestyle promotes healthy well-being. Shodhana (purificatory measures) are one lifestyle modification done to conserve health or treat disorders, especially during the onset of seasonal variations. Ayurveda suggests ‘Swasthasya Swasthya Rakshanam Aturasya Vikara Prashamanam', which indicates preventive and curative management. This is necessary for the present environmental conditions as each seasonal variation marks a phase for the onset of various ill effects on health. So hereby, focussing on one Ritu – Sharat Ritu in which Virechana is considered a primary purificatory measure as Pitta dosha prakopa occurs in this Ritu. One has to focus on Ritu lakshanas, body constitution and dosha avastha of an individual rather than the calendar months in which seasonal variations are prebound to occur.
Effectiveness of WhatsApp in Delivering Livestock Advisory Services in Andhra Pradesh
Authors: Shobha P. , Sharma G. R. K. , Triveni G.
Published: May 2023

In the present ICT era of communication, social media is playing a pivotal role in reducing the communication gap and sharing the information instantly anywhere in the world. Among various social media, WhatsApp particularly helps in formation of common interest groups for different categories of people for sharing information. The present study was undertaken with this objective, to study the effectiveness of WhatsApp communications on advisory services delivered to the livestock owners, in Andhra Pradesh. A WhatsApp group named “PASU VIGNANA VEDIKA” was created for the study purpose, to provide the livestock related information to the farmers instantly. A total of 95 farmers and 10 Veterinary Officers, using WhatsApp in their smart phones were selected and included in PASU VIGNANA VEDIKA”. After 90 days of study period, the results were collected by personal interview method through structured interview schedule, analyzed and presented in frequencies and percentages. The majority of the livestock farmers had Favourable attitude (61.05%)  towards using the WhatsApp group for farming purpose, opined that the information is easy to read (100%), and listen (89%), timely availability (89.47%), out of the queries posted in WhatsApp group majority were regarding health of animals (54.17%) especially skin, mastitis and digestive disorders. Further, most of the farmers used text based messages (56.25%)  followed by photos (31.25%) of ailing animals. In view of the vast opportunities through WhatsApp group formation, government policies should be framed in such a way to utilize the full potential of this method of communication for the welfare of farming community.
Emotional Freedom Techniques for Childhood Sexual Abuse Survivors
Authors: Soriano-Lemen Maria Isabel , Lamzon Gina
Published: May 2023

Childhood Sexual Abuse (CSA) is a phenomenon that has affected the lives of many women and female adolescents. Eleven (11) residents of a center for abused females were included in this study. Using the case study research method of Yin, data was gathered from multiple sources. Findings were (1)emotion regulation skills were enhanced for some participants; (2) estrangement or hostility from family contributed to the prevalence of the symptoms; (3) some participants’ precursor to change characteristics may have hindered therapy progress; (4) EFTs lack an emphasis on building therapeutic alliance; (5)Cognitive Behavioral Theory when used with EFTs make the sessions more helpful; (6) outside factors may have affected the worsening or reduction of symptoms; (7) there is a need to distinguish between tapping for day-to-day management of emotions and tapping on core issues; and (8) assessment, case conceptualization, and the preparation of a treatment plan play an important role, if there is to be treatment success. Recommendations include suggestions to enhance the therapeutic process, considerations that need to be made in relation to symptomatology of CSA survivors, their precursor to change characteristics, standardizing the implementation of EFTs, and integrating Cognitive Behavioral Theory with EFTs so that a more structured therapeutic approach can be made.
Hearing Impairment; Barrier to Social Participation for Secondary School Students in Meru District-Arusha
Authors: Fultang Esther Mallya , Kiwia Rose Haynes
Published: May 2023

This study assessed barriers to social participation for secondary school students with hearing impairment in Meru District, Arusha. The study was guided by the Social Disability theory. Qualitative (descriptive) research design were applied whereby a total of 143 respondents were included in the study. Data were collected through focus group discussion (FGDs), interview and classroom observation. Thematic analysis was used to analyze qualitative data. The findings revealed that lack of sign language interpreters and discrimination of people with HI in the community leads to their poor participation in the community.  This study concluded that there is a need to create awareness among community members that hearing impairment is a medical condition that can be handled. Based on the findings, it was recommended that the government of Tanzania should introduce sign language lesson from primary schools to tertiary institutions basically to enhance interaction between learners with hearing impairment and other people in the society.