bluuebunny/crossref_metadata_2025 huggingface dataset:
PERUBAHAN LIVELIHOOD MASYARAKAT SETELAH TINGGAL DI RUMAH SUSUN SEDERHANA SEWA (STUDI KASUS: RUSUNAWA SEJUTA KANAL, KABUPATEN INDRAGIRI HILIR, RIAU)
Authors: Afriansyah Faizal , Urifi Zulfadly
Published: August 2024

Rusunawa yang terletak di Kabupaten Indragiri Hilir dibangun dengan tujuan relokasi masyarakat berpenghasilan rendah yang tinggal di bantaran Sungai Indragiri. Pengadaan Rusunawa diharapkan dapat meningkatkan kualitas hidup masyarakat. Namun, beberapa pengadaan Rusunawa tidak berdampak pada peningkatan kualitas hidup (Livelihood) penghuninya. Diperlukan penelitian untuk mengidentifikasi perubahan Livelihood masyarakat setelah tinggal di Rusunawa. Tujuan dari penelitian ini yakni untuk mengidentifikasi perubahan Livelihood penghuni rumah susun sederhana sewa setelah pindah ke rumah susun sederhana sewa melalui pendekatan Sustainable Urban Livelihood (SUL). Penelitian ini dapat menjadi bahan evaluasi Pemerintah untuk mengetahui tingkat keberhasilan program yang sudah dibangun. Analisis yang digunakan adalah analisis 5 aset Livelihood dengan metode Paired Sample T-Test. Berdasarkan hasil penganalisisan kualitas Livelihood sebelum dan setelah perpindahan tempat tinggal terhadap 5 aset Livelihood yaitu aset manusia, alam, sosisal, fisik, dan finansial, dapat disimpulkan terjadi perubahan berupa peningkatan kualitas Livelihood. Selain itu, setelah dilakukan penganalisisan lanjutan menggunakan Paired Sample T-Test didapatkan adanya perubahan signifikan dari perpindahan tempat tinggal terhadap perubahan kualitas Livelihood masyarakat. Maka artinya kualitas Livelihood masyarakat rumah susun sederhana sewa dapat dikatakan baik karena mampu memberikan perubahan kearah yang lebih baik.
Differences in global, regional, and national time trends in disability-adjusted life years for atrial fibrillation and flutter, 1990–2019: an age-period-cohort analysis from the 2019 global burden of disease study
Authors: Tang Juan , Zhang Qingwei , Peng Shengxian , Li Huan , Hu Weike , Hao Min , Liu Yue , Sun Mengyan , Cao Wenzhai , Yin Niying , Liu Xiaozhu , Xu Te
Published: August 2024

Background

Atrial fibrillation and flutter, collectively referred to as AF/AFL, pose substantial public health challenges across nations of different economic statuses.

Abjective

This research is intended to assess the discrepancies in global, regional, and national trends in DALYs for atrial fibrillation and flutter throughout 1990 and 2019.

Methods

The GBD 2019 report included statistics on AF/AFL. An age-period-cohort (APC) model was used to calculate the changes in DALYs from ages 30 to 34 years up to 95 + years. The model calculated both net drifts and local drifts in DALYs. In addition, we analysed the relative risks for certain time periods and birth cohorts from 1990 to 2019 in order to assess their impact. In order to measure the changes over time in the age-standardized rate (ASR) of DALYs caused by AF/AFL, we calculated the average annual percentage changes (AAPCs) based on age, gender, socio-demographic index (SDI), and location. This approach enables us to analyse the impact of age, period, and cohort on trends in DALYs, which may uncover disparities in the management of AF/AFL.

Results

The global number of DALYs cases was 8,393,635 [95% uncertainty interval (UI): 6,693,987 to 10,541,461], indicating a 121.6% rise (95% UI: 111.5 to 132.0) compared to 1990. From 1990 to 2019, the worldwide ASR of DALYs decreased by 2.61% (95% UI −6.9 to 1.3). However, the other SDI quintiles, except for high SDI and high-middle SDI, had an increase. During the last three decades, high-income nations in the Asia Pacific region had the most significant reduction in ASR of DALYs, whereas Central Asia experienced the highest rise (with a net drift of −0.9% [95% Confidence Interval (CI): −1.0 to −0.9] and 0.6% [95% CI: 0.5 to 0.7], respectively). Approximately 50% of the burden of AF/AFL has been transferred from areas with high and high-middle SDI to those with lower SDI. There was an inverse relationship between the AAPC and the SDI. In addition, men and older individuals were shown to have a greater burden of AF/AFL DALYs.

Conclusion

The findings of this research demonstrate that the worldwide impact of AF/AFL remains significant and increasing, with the burden differing depending on SDI. The exhaustive and comparable estimates provided by these results may contribute to international efforts to attain equitable AF/AFL control.
Assessment of the effect of the SLC5A2 gene on eGFR: a Mendelian randomization study of drug targets for the nephroprotective effect of sodium-glucose cotransporter protein 2 inhibition
Authors: Liu Gailing
Published: August 2024

Aim

Sodium-glucose cotransporter protein 2 (SGLT2) inhibitors have been shown to have renoprotective effects in clinical studies. For further validation in terms of genetic variation, drug-targeted Mendelian randomization (MR) was used to investigate the causal role of SGLT2 inhibition on eGFR effects.

Methods

Genetic variants representing SGLT2 inhibition were selected as instrumental variables. Drug target Mendelian randomization analysis was used to investigate the relationship between SGLT2 inhibitors and eGFR. The IVW method was used as the primary analysis method. As a sensitivity analysis, GWAS pooled data from another CKDGen consortium was used to validate the findings.

Results

MR results showed that hemoglobin A1c (HbA1c) levels, regulated by the SLC5A2 gene, were negatively correlated with eGFR (IVW β -0.038, 95% CI -0.061 to -0.015, P = 0.001 for multi-ancestry populations; IVW β -0.053, 95% CI -0.077 to -0.028, P = 2.45E-05 for populations of European ancestry). This suggests that a 1-SD increase in HbA1c levels, regulated by the SLC5A2 gene, is associated with decreased eGFR. Mimicking pharmacological inhibition by lowering HbA1c per 1-SD unit through SGLT2 inhibition reduces the risk of eGFR decline, demonstrating a renoprotective effect of SGLT2 inhibitors. HbA1c, regulated by the SLC5A2 gene, was negatively correlated with eGFR in both validation datasets (IVW β -0.027, 95% CI -0.046 to -0.007, P=0.007 for multi-ancestry populations, and IVW β -0.031, 95% CI -0.050 to -0.011, P=0.002 for populations of European origin).

Conclusions

The results of this study indicate that the SLC5A2 gene is causally associated with eGFR. Inhibition of SLC5A2 gene expression was linked to higher eGFR. The renoprotective mechanism of SGLT2 inhibitors was verified from the perspective of genetic variation.
Evaluation of heavy metal fixation ability from drilling waste of oil and gas wells using treated sugarcane bagasse
Authors: Saffarian Farhad , Hosseini Seyed Ahmad , Mohammadi Roozbahani Maryam , Etminan Alireza
Published: August 2024

Introduction

The drilling industry is one of the main sectors of the oil industry, and oil drilling is one of the most specialized industrial activities. Large-scale production of sugarcane bagasse in Khuzestan Province creates an environmental opportunity to utilize this agricultural byproduct in different sections as a valuable byproduct. This study aimed to investigate the ability of the raw form of bagasse and its transformed structure in heavy metal fixation in drilling mud and to investigate the efficiency of crude bagasse, processed bagasse, and biochar adsorbents in removing heavy metals from the drilling mud residues of Ahvaz oil field.

Methods

Sampling of drilling mud waste from Mishan Geological Formation (MGF) and Aghajari Geological Formation (AGF) was done on a vibrating sieve. The treatments examined in this research include the contact time in six levels (30, 60, 90, 120, 150, and 180 min), amount of the adsorbent in three levels (0.1, 0.5, and 1 g), adsorbent type in three levels (crude bagasse, processed bagasse, and biochar), and the formation type in two levels (Aghajari and Mishan). After chemical digestion, the samples were placed in contact with crude bagasse, processed bagasse, and biochar according to the designed conditions. Then, the removal percentages of Ba, Ni, V, Cd, Fe, and Pb were calculated. Means were compared using Duncan’s test at the 1% level.

Results and Discussion

The results showed that the biochar adsorbent is the most efficient compared to other adsorbents. The maximum removal percentages of heavy metals Ba, Ni, V, Cd, Fe, and Pb by crude bagasse are 72.53%, 68.89%, 79.49%, 76.88%, 49.42%, and 85%, respectively. In addition, the results showed that the maximum removal percentages of heavy metals Ba, Ni, V, Cd, Fe, and Pb by crude bagasse are 81/72%, 83/89%, 86/67%, 83/44%, 64/41%, and 90.72%, respectively. The maximum efficiency of biochar for adsorbing heavy metals Ba, Ni, V, Cd, Fe, and Pb is 90.70%, 91.84%, 88.89%, 88.75%, 78.59%, and 97.75%, respectively. The maximum amount of heavy metals adsorbed by all adsorbents was 1 gr/L, and the adsorption efficiency increased by increasing the amount of the adsorbent from 0.2 to 1 gr/L. In examining the effect of contact time, the maximum removal percentage of heavy metals barium and cadmium was obtained in 120 min, nickel and lead in 90 min, and vanadium and iron in 60 min. After the above contact times, there was no increase in the maximum percentage of metal removal.
Self-care for maternal and reproductive health in conflict settings: qualitative case study in Nuba Mountains, Sudan
Authors: Hafez Sali , Samson Stella Sadia , Tanner Lydia , Pendle Naomi
Published: August 2024

Introduction

Self-care is a critical component of Reproductive, Maternal, and Neonatal Health (RMNH), offering women the knowledge, skills, and autonomy needed for well-being throughout the reproductive cycle. This paper explores the significance of self-care in conflict-affected regions, where access to formal healthcare is limited. Such areas place pregnant women at higher risk due to increased incidents of adverse events during pregnancy and childbirth. Self-care interventions have the potential to enhance access to quality healthcare services.

Methods

Employing a qualitative approach, this study explores RMNH self-care practices among pregnant and post-natal women in the Nuba Mountains. The methods included in-depth semi-structured interviews with 24 participants, comprising pregnant women, recent mothers, and healthcare providers. Purposive sampling was used to capture the experiences of mothers, and thematic analysis identified key patterns and themes in self-care practices. The perspectives of healthcare professionals were included to understand the context of RMNH care in conflict settings.

Results

The study revealed the crucial role of community cohesion in providing emotional and practical support in pregnancy, childbirth, and in the post-natal period. Limited healthcare infrastructure and ongoing conflict-related challenges provided important drivers for self-care practices. A spectrum of self-care interventions ranged from personal hygiene practices to community-supported childbirth and postnatal care. Significant reliance on elder women's wisdom and traditional midwifery was observed, particularly in the absence of formal healthcare facilities. Some women moved to live with family close to the hospital in the weeks before their due dates in order to mitigate the risks of early deliveries, complications, or general insecurity in their home areas.

Discussion

The findings present a compelling narrative of communal self-care, challenging the conventional notion of self-care as solely individualistic. In this setting, the community's role is fundamental, with knowledge sharing and mutual support forming the bedrock of maternal health practices. Elder women, embodying repositories of perceived traditional wisdom, emerge as central figures, guiding pregnant and postpartum women through shared experiences and practices. This collective approach is not merely a cultural characteristic but a necessity born out of the region's limited healthcare infrastructure and ongoing conflict. The study underscores the need to recognize and integrate these communal self-care strategies into broader health interventions.
The role of B7-H4 in ovarian cancer immunotherapy: current status, challenges, and perspectives
Authors: Zhou Lu , Duan Yuanqiong , Fu Kaiyu , Zhang Mengpei , Li Kemin , Yin Rutie
Published: August 2024

Immunotherapy stands as a critical and auspicious therapeutic approach in the fight against cancer nowadays. Immune checkpoint inhibitors, in particular, have garnered widespread employment and delivered groundbreaking therapeutic outcomes across various malignancies. However, the efficacy is unsatisfactory in the ovarian cancer. The pressing concerns of the substantial non-response rate require immediate attention. The pursuit of novel targets and the formulation of synergistic combination therapy approaches are imperative for addressing this challenge. B7-H4, a member of the B7 family of co-inhibitory molecules, exhibits high expression levels in ovarian cancer, correlating closely with tumor progression, drug resistance, and unfavorable prognosis. B7-H4 has the potential to serve as a valuable biomarker for evaluating the immune response of patients. Recent investigations and preclinical trials focusing on B7-H4 in the context of ovarian cancer immunotherapy highlight its emergence as a promising immunotherapeutic target. This review aims to discuss these findings and anticipate the future prospects of leveraging B7-H4 in ovarian cancer immunotherapy and targeted therapy.
Groundtruthing nitrogen isotopes as a symbiosis proxy using the facultatively symbiotic coral Oculina arbuscula
Authors: Donnelly Heather A. , Valadez-Ingersoll Maria , Lin Marcus , Rivera Hanny E. , Tramonte Carlos A. , Davies Sarah W. , Wang Xingchen Tony
Published: August 2024

The resilience of coral reefs in oligotrophic, (sub)tropical oceans is largely due to the symbiotic relationship between scleractinian corals and Symbiodiniaceae algae, which enables efficient internal nutrient recycling. Investigating the history of this coral symbiosis can provide insights into its role in sustaining the health of both present and future coral reefs. The isotopic composition of organic nitrogen (15N/14N or δ15N) bound within coral skeletons has been utilized to trace the existence of symbiosis in fossil corals, suggesting that coral symbiosis dates back to at least 210 million years ago. The basis of this proxy is that symbiotic corals are expected to exhibit lower δ15N compared to their non-symbiotic (aposymbiotic) counterparts within the same environments, owing to internal nitrogen recycling between the coral host and algal symbiont, and reduced leakage of low-δ15N ammonium into seawater. However, this hypothesis has not been adequately tested in contemporary settings. In a laboratory experiment, we examined the δ15N differences between the symbiotic and aposymbiotic branches within the same genetic backgrounds of the facultatively symbiotic coral Oculina arbuscula under well-fed conditions. Across five different genotypes in two separate experiments, symbiotic branches consistently showed lower δ15N than their aposymbiotic counterparts. These findings corroborate the use of δ15N as a proxy for identifying coral symbiosis in the past, particularly when multiple species of corals coexisted in the same environments.
Potentially inappropriate prescribing in elderly patients with epilepsy at two referral hospitals in Ethiopia
Authors: Tadesse Tamrat Assefa , Belayneh Alemu , Aynalem Minychel Wale , Yifru Yared Mamushet , Amare Firehiwot , Beyene Dessale Abate
Published: August 2024

Introduction

The prevalence of drug therapy problems in patients with epilepsy has been reported to be as high as 70–90%. Moreover, elderly patients with epilepsy are highly vulnerable to inappropriate therapies. This study aimed to evaluate potentially inappropriate prescriptions (PIP) in elderly patients with epilepsy at the adult neurology clinics of two referral hospitals in Addis Ababa, Ethiopia.

Methods

A cross-sectional study was conducted on 81 patients with epilepsy and the medication appropriateness index (MAI), the Beers, and Screening Tool of Older Persons’ Prescriptions and Screening Tool to Alert to the Right Treatment (STOPP/START) criteria were used to assess PIP. Data were analyzed using the Statistical Package for the Social Sciences (SPSS) version 25.

Results

Of the 81 study participants, 41(50.6%) were male, and the mean age was 67.33 ± 17.43 years. One-fourth of the study participants (25.9%) had polypharmacy and drug-drug interactions (DDIs) were documented in 64 (79%) patients. Based on the MAI, of the 263 medications that were prescribed for elderly epileptic patients, 110 (41.8%) had drug interactions, 44 (16.7%) had inappropriate indications, 31 (11.8%) were ineffective, and 12 (4.6%) were prescribed incorrect doses. Based on the STOPP and START criteria, PIP was reported in 31(38.3%) and 13(16.1%) patients, respectively.

Conclusion

Polypharmacy and DDIs are common in elderly epilepsy patients. The MAI, Beer’s criteria, and STOPP/START criteria indicate a high prevalence of PIP in elderly patients with epilepsy.
Molecular mechanisms of Sepsis attacking the immune system and solid organs
Authors: Yang Zhaoyun , Gao Yan , Zhao Lijing , Lv Xuejiao , Du Yanwei
Published: August 2024

Remarkable progress has been achieved in sepsis treatment in recent times, the mortality rate of sepsis has experienced a gradual decline as a result of the prompt administration of antibiotics, fluid resuscitation, and the implementation of various therapies aimed at supporting multiple organ functions. However, there is still significant mortality and room for improvement. The mortality rate for septic patients, 22.5%, is still unacceptably high, accounting for 19.7% of all global deaths. Therefore, it is crucial to thoroughly comprehend the pathogenesis of sepsis in order to enhance clinical diagnosis and treatment methods. Here, we summarized classic mechanisms of sepsis progression, activation of signal pathways, mitochondrial quality control, imbalance of pro-and anti- inflammation response, diseminated intravascular coagulation (DIC), cell death, presented the latest research findings for each mechanism and identify potential therapeutic targets within each mechanism.
Focused extracorporeal shockwave therapy for the treatment of low back pain: a systematic review
Authors: Ferdinandov Dilyan
Published: August 2024

Introduction

Low back pain (LBP) is a common condition affecting up to 84% of people in their lifetime, with a prevalence of 11.9% and a high recurrence rate within the first year. Furthermore, chronic low back pain syndrome has been described in up to 7%, making it a significant health and socioeconomic problem. Among nonoperative treatment options, the recently used focused extracorporeal shockwave therapy (ESWT) devices generate waves that converge at a precise depth in the body, thereby revealing the potential to affect pathology remotely from the contact surface. The article aims to present a systematic literature review with a critical discussion on treating low back pain using this modality.

Methods

A search for randomized controlled trials (RCT) of focused ESWT for low back pain published before April 1, 2024, in PubMed, Web of Science, Scopus, Google Scholar, and trial registries (WHO International Clinical Trials Registry Platform and ClinicaTrials.gov) was performed.

Results

Only three studies against conservative treatment comprising 94 patients met the selection criteria and were further analyzed. Comparative clinical studies regarding the effectiveness of radial and focused ESWT for low back pain were missing. The results revealed that all treated patients had significantly reduced pain and improved functional impairment immediately after the procedures and 1 month later. At the third month time point, the pain levels remained better in the experimental than in the control group without achieving statistical significance. None of the studies had a long-term follow-up.

Conclusion

Focused ESWT is a modern physiotherapeutic method that can potentially treat a broad spectrum of conditions responsible for low back pain. Despite the small number of low-evidence studies, there is sufficient data on the effectiveness and safety of this therapeutic modality. With future well-designed trials, the bias risks would be diminished, the indications for its use would expand, and the treatment protocols would be clarified.
Comparison of sinonasal symptoms in upper respiratory tract infections during the infectious diseases season of November 2023 to March 2024—a cross-sectional study
Authors: Straburzyński Marcin , Romaszko-Wojtowicz Anna
Published: August 2024

Introduction

Upper respiratory tract infections (URTIs) are among the most common reasons for patients consulting a general practitioner (GP) during the infectious diseases season, with viruses being the predominant cause. The COVID-19 pandemic has significantly impacted GPs’ perception of these infections. The pandemic’s progression, especially with the emergence of the Omicron variant, has complicated the diagnosis and treatment of URTIs, with evolving symptoms.

Aim

The aim of this study was to assess the differences in symptoms reported by patients with various infections, such as COVID-19, influenza, common cold, and post-viral rhinosinusitis, during the infectious diseases season of November 2023 to March 2024.

Materials and methods

The study was conducted in a primary health care clinic, providing care for a population of approximately 10,000 people, among adult patients presenting with URTI symptoms during the 2023/2024 infectious diseases season. Patients qualified for the study were swabbed for SARS-CoV-2, influenza A and B and respiratory syncytial virus (RSV) antigens. Symptoms were assessed with the use of a semi-structured questionnaire.

Results

Of the 1810 patients presenting with symptoms of URTIs, 276 patients were included in the study. Among patients with COVID-19, symptoms of nasal obstruction (p = 0.005) and nasal discharge (p = 0.001) were less common than in those with influenza or common cold. However, these nasal symptoms were significantly more frequent among patients with COVID-19 who had confirmed previous immunization (COVID-19 history or vaccination) (p = 0.028).

Conclusion

The incidence of individual sinonasal symptoms varies significantly depending on the aetiological agent of the URTI. This observation may not only help clinicians make the correct diagnosis, but also suggests an inflammatory response in the nasal mucosa and paranasal sinuses that is dependent on the aetiological agent. The study also indicates that this response is altered within the same virus species following immunization.

Limitations

The study’s limitations include a small sample size (276 patients), focus on one season and one GP practice, and reliance on clinical signs and antigen tests. Nonetheless, the findings provide valuable insights. Further research with larger patient groups and extended follow-up periods is required to confirm these findings.
Association between systemic immune-inflammation index and atopic dermatitis: a cross-sectional study of NHANES 2001–2006
Authors: Ding Qike , Lin Lihong , Li Xiaoting , Xie Xiaoping , Lu Tao
Published: August 2024

Background

While several studies have noted a higher SII correlates with multiple diseases, research on the association between SII and atopic dermatitis remains limited. Our cross-sectional study seeks to examine the association between SII and atopic dermatitis among outpatient US adults.

Methods

This compensatory cross-sectional study utilized NHANES data from 2001–2006 cycles, conducting sample-weighted multivariate logistic regression and stratified analysis of sub-groups.

Results

Higher levels of SII were positively associated with an increased risk of atopic dermatitis in adults with BMI <30 (OR, 1.44; 95% CI, 1.10–1.90) (p = 0.010).

Conclusion

Our findings suggested SII higher than 330 × 109/L was positively associated with a high risk of atopic dermatitis in US adults with BMI <30. To our knowledge, this is the first study focused on the risk of higher SII on atopic dermatitis in the outpatient US population. Currently, there are differences in the standards used to diagnose atopic dermatitis across countries, and our study may have implications.
Mixed Bacillus subtilis and Lactiplantibacillus plantarum-fermented feed improves gut microbiota and immunity of Bamei piglet
Authors: Chen Jun , Mou Liyu , Wang Lei , Wu Guofang , Dai Ximei , Chen Qiufang , Zhang Jianbo , Luo Xuan , Xu Fafang , Zhang Miao , Duan Yaoke , Pang Huili , Wang Yanping , Cai Yimin , Tan Zhongfang
Published: August 2024

Antibiotics are widely used in the breeding production of Bamei pigs, affecting the quality and safety of pork and causing enormous harm to human health, the environment, and public health. The use of probiotic fermented feed to replace antibiotic feed is one of the solutions, which has the potential to improve the intestinal microbiota, promote animal growth, and enhance immunity. The purpose of this study was to evaluate the effect of fermented feed with Lactiplantibacillus (L.) plantarum QP28-1a or Bacillus (B.) subtilis QB8a on feed, growth performance, gut microbiota, and immunity of weaned piglets. A total of 60 freshly weaned piglets from the Tibetan Plateau were randomly divided into five groups and fed basal feed, L. plantarum fermented feed, B. subtilis fermented feed, mixed fermented feed, and antibiotic fermented feed for 60 days, respectively. The results showed fermented feed supplemented with L. plantarum QP28-1a or B. subtilis QB8a significantly lowered the pH of the feed (P < 0.05), produced lactic acid and acetic acid, inhibited the growth of harmful bacteria in the feed, and reduced the feed conversion rate in the group fed mixed fermented feed (P < 0.05). The fermented feed increased the α-diversity and prominently altered the β-diversity of the intestinal microbiota, increasing the relative abundance of beneficial bacteria such as Lactobacillus and Turicibacter and decreasing the relative abundance of conditional pathogens such as Streptococcus and Clostridium, improving the intestinal microbiota of the Bamei piglets. Notably, the mixed fermented feed improved the immunity of Bamei piglets by modulating the production of pro-inflammatory cytokines, anti-inflammatory cytokines, and inflammatory-related signaling pathways. Spearman’s correlation analysis revealed that the increased expression of immune-related cytokines may be associated with a significant enrichment of Lactobacillus, Prevotellaceae, Erysipelotrichaceae, and Ruminococcaceae in the gut. In conclusion, the probiotic fermented feed maintained an acidic environment conducive to suppressing pathogens, reduced the feed conversion ratio, optimized the intestinal microbiota, improved immunity, and alleviated intestinal inflammation that may be caused by weaning, demonstrating the excellent application prospects of L. plantarum QP28-1a and B. subtilis QB8a fermented feed in the feeding of Bamei piglets.
Deep-learning-based segmentation of perivascular spaces on T2-Weighted 3T magnetic resonance images
Authors: Cai Die , Pan Minmin , Liu Chenyuan , He Wenjie , Ge Xinting , Lin Jiaying , Li Rui , Liu Mengting , Xia Jun
Published: August 2024

Purpose

Studying perivascular spaces (PVSs) is important for understanding the pathogenesis and pathological changes of neurological disorders. Although some methods for automated segmentation of PVSs have been proposed, most of them were based on 7T MR images that were majorly acquired in healthy young people. Notably, 7T MR imaging is rarely used in clinical practice. Herein, we propose a deep-learning-based method that enables automatic segmentation of PVSs on T2-weighted 3T MR images.

Method

Twenty patients with Parkinson’s disease (age range, 42–79 years) participated in this study. Specifically, we introduced a multi-scale supervised dense nested attention network designed to segment the PVSs. This model fosters progressive interactions between high-level and low-level features. Simultaneously, it utilizes multi-scale foreground content for deep supervision, aiding in refining segmentation results at various levels.

Result

Our method achieved the best segmentation results compared with the four other deep-learning-based methods, achieving a dice similarity coefficient (DSC) of 0.702. The results of the visual count of the PVSs in our model correlated extremely well with the expert scoring results on the T2-weighted images (basal ganglia: rs = 0.845, P < 0.001; rs = 0.868, P < 0.001; centrum semiovale: rs = 0.845, P < 0.001; rs = 0.823, P < 0.001 for raters 1 and 2, respectively). Experimental results show that the proposed method performs well in the segmentation of PVSs.

Conclusion

The proposed method can accurately segment PVSs; it will facilitate practical clinical applications and is expected to replace the method of visual counting directly on T1-weighted images or T2-weighted images.
Spatial memory and learning: investigating the role of dynamic visual acuity
Authors: Kabiş Burak , Gürses Emre , Işıkay Ayşe Ýlksen Çolpak , Aksoy Songül
Published: August 2024

Introduction

The vestibular system’s contribution to spatial learning and memory abilities may be clarified using the virtual Morris Water Maze Task (vMWMT). This is important because of the connections between the vestibular system and the hippocampus area. However, there is ongoing debate over the role of the vestibular system in developing spatial abilities. This study aimed to evaluate the relationship between Dynamic Visual Acuity (DVA) across three planes and spatial abilities.

Methods

This cross-sectional study was conducted with 50 healthy adults aged 18 to 55 with normal stress levels and mental health and no neurological, audiological, or vestibular complaints. The Trail-Making Test (TMT) Forms A and B for the assessment of executive functions, the DVA test battery for the evaluation of visual motor functions, and the Virtual Morris Water Maze Test (vMWMT) for the assessment of spatial learning and spatial memory were performed. All participants also underwent the Benton Face Recognition Test (BFRT) and Digit Symbol Substitution Tests (DSST) to assess their relation with spatial memory.

Results

DVA values in horizontal (H-DVA), vertical (V-DVA), and sagittal (S-DVA) planes ranged from (−0.26) to 0.36 logMAR, (−0.20) to 0.36 logMAR, and (−0.28) to 0.33 logMAR, respectively. The latency of three planes of DVA was affected by vMWMT (Horizontal, Vertical, and Sagittal; Estimate: 22.733, 18.787, 13.341, respectively p < 0.001). Moreover, a moderately significant correlation was also found, with a value of 0.571 between the Virtual MWM test and BFRT and a value of 0.539 between the DSST (p < 0.001).

Conclusion

Spatial abilities in healthy adults were significantly influenced by dynamic visual functions across horizontal, vertical, and sagittal planes. These findings are expected to trigger essential discussions about the mechanisms that connect the vestibular-visual system to the hippocampus. The original vMWMT protocol is likely to serve as a model for future studies utilizing this technology.
The evolution of mesenchymal stem cell-derived neural progenitor therapy for Multiple Sclerosis: from concept to clinic
Authors: Ghareghani Majid , Arneaud Ayanna , Rivest Serge
Published: August 2024

This review delves into the generation and therapeutic applications of mesenchymal stem cell-derived neural progenitors (MSC-NPs) in Multiple Sclerosis (MS), a chronic autoimmune disease characterized by demyelination, neuroinflammation, and progressive neurological dysfunction. Most current treatment paradigms primarily aimed at regulating the immune response show little success against the neurodegenerative aspect of MS. This calls for new therapies that would play a role in neurodegeneration and functional recovery of the central nervous system (CNS). While utilizing MSC was found to be a promising approach in MS therapy, the initiation of MSC-NPs therapy is an innovation that introduces a new perspective, a dual-action plan, that targets both the immune and neurodegenerative mechanisms of MS. The first preclinical studies using animal models of the disease showed that MSC-NPs could migrate to damaged sites, support remyelination, and possess immunomodulatory properties, thus, providing a solid basis for their human application. Based on pilot feasibility studies and phase I clinical trials, this review covers the transition from preclinical to clinical phases, where intrathecally administered autologous MSC-NPs has shown great hope in treating patients with progressive MS by providing safety, tolerability, and preliminary efficacy. This review, after addressing the role of MSCs in MS and its animal model of experimental autoimmune encephalomyelitis (EAE), highlights the significance of the MSC-NP therapy by organizing its advancement processes from experimental models to clinical translation in MS treatment. It points out the continuing obstacles, which require more studies to improve therapeutic protocols, uncovers the mechanisms of action, and establishes long-term efficacy and safety in larger controlled trials.
Effect of non-invasive brain stimulation in children with acquired brain injury—a scoping review
Authors: Rathinam Chandrasekar , Mohan Vikram , Yates Derick , Bill Peter , Peirson Janet , Gupta Rajat
Published: August 2024

Background

Children and young people (CYP) with acquired brain injury (ABI) require early and effective neurorehabilitation to improve long-term functional outcomes. Non-invasive brain stimulation (NIBS), including transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), have been used to improve motor and sensory skills for children with cerebral palsy. However, there is limited evidence supporting its use in CYP with ABI.

Objective

To systematically review the TMS and tDCS intervention effects on motor, sensory and other functional issues in CYP with ABI as reported in the literature.

Methods

A comprehensive online bibliographic databases search was performed in various databases using keywords related to NIBS and CYP with ABI. Studies that examine the effect of NIBS intervention on motor function and other functional difficulties either as a primary or secondary objective were included in this review.

Results

Fourteen studies (10 single case reports, one retrospective analysis, one case series, one randomised and one quasi-randomised controlled trial) published between 2006 and 2023 were identified. These studies examined the use of NIBS to manage motor disorders, hearing, vision, headaches, speech and language and memory issues. Seventy-six children with mild to severe ABI had received NIBS. The session frequency (3–20), duration (10–45 min) was variable, and NIBS delivered between 3 and 28 days.

Conclusion

The literature describing NIBS interventions in CYP with ABI is scarce. An insufficient number of studies, inadequate information reported in them, and small sample sizes limit the ability to conclude how effective NIBS is in improving motor function and other functional issues in this cohort. Further studies are therefore necessary to examine the therapeutic effects of NIBS to manage various functional problems in the CYP with ABI.
Creutzfeldt-Jakob disease presenting as psychiatric disorder: case presentation and systematic review
Authors: Huang Brendan , Shafiian Neeva , Masi Paul Joseph , Gordon Marc L. , Franceschi Ana M. , Giliberto Luca
Published: August 2024

Creutzfeldt-Jakob disease (CJD) is a spongiform encephalopathy caused by misfolded human prion proteins (PrP)s. Due to variability in presentation, the diagnosis may be missed in lieu of various psychiatric disorders. Our study reports on a prototypical case and psychiatric mimic for CJD, and the workup used to establish the correct diagnosis. A 54-year-old male with a past medical history of traumatic brain injury and major depressive disorder presented with chest pain. During the hospital stay, he was found to be increasingly aggressive, and behaved out of character. Further review of clinical history revealed that the patient was diagnosed with cognitive impairment and depression one year prior. The patient was agitated, poorly redirectable, and had unstable gait on neurological examination. Magnetic resonance imaging (MRI) of the brain demonstrated restricted diffusion (DWI) along the parietooccipital and temporal regions (L > R) and in the subcortical structures, including the basal ganglia and thalami, with accompanying subtle fluid attenuation inversion recovery (FLAIR) hyperintense signal abnormality in these regions, deemed as artifactual at the time. Repeat MRI brain two months later demonstrated progression of the DWI signal with ADC correlate and FLAIR findings. Cerebrospinal fluid 14-3-3 and RT-QuIC samples were positive. Upon passing a few months later, brain autopsy and Western Blot confirmed the CJD diagnosis. Literature review was conducted on PubMed to identify CJD cases initially diagnosed as psychiatric disorder. Search terms included “CJD” or “Creutzfeldt-Jakob disease” with three common psychiatric diagnoses, “Depression,” “Psychosis,” and “Mania.” Positive EEG, MRI, PET, and CSF (including protein 14-3-3 and tau) findings for CJD were found in 66.7, 81.1, 50, and 72.7% of cases, respectively. Overall, CJD can present as a psychiatric mimic. In suspicious cases, EEG, imaging, and CSF studies should be promptly utilized to arrive at the correct diagnosis. Repeated MRI imaging is often required to help in the diagnostic process. Brain biopsy should be considered in selected cases.
Target engagement of the subgenual anterior cingulate cortex with transcranial temporal interference stimulation in major depressive disorder: a protocol for a randomized sham-controlled trial
Authors: Demchenko Ilya , Rampersad Sumientra , Datta Abhishek , Horn Andreas , Churchill Nathan W. , Kennedy Sidney H. , Krishnan Sridhar , Rueda Alice , Schweizer Tom A. , Griffiths John D. , Boyden Edward S. , Santarnecchi Emiliano , Bhat Venkat
Published: August 2024

Background

Transcranial temporal interference stimulation (tTIS) is a new, emerging neurostimulation technology that utilizes two or more electric fields at specific frequencies to modulate the oscillations of neurons at a desired spatial location in the brain. The physics of tTIS offers the advantage of modulating deep brain structures in a non-invasive fashion and with minimal stimulation of the overlying cortex outside of a selected target. As such, tTIS can be effectively employed in the context of therapeutics for the psychiatric disease of disrupted brain connectivity, such as major depressive disorder (MDD). The subgenual anterior cingulate cortex (sgACC), a key brain center that regulates human emotions and influences negative emotional states, is a plausible target for tTIS in MDD based on reports of its successful neuromodulation with invasive deep brain stimulation.

Methods

This pilot, single-site, double-blind, randomized, sham-controlled interventional clinical trial will be conducted at St. Michael’s Hospital – Unity Health Toronto in Toronto, ON, Canada. The primary objective is to demonstrate target engagement of the sgACC with 130 Hz tTIS using resting-state magnetic resonance imaging (MRI) techniques. The secondary objective is to estimate the therapeutic potential of tTIS for MDD by evaluating the change in clinical characteristics of participants and electrophysiological outcomes and providing feasibility and tolerability estimates for a large-scale efficacy trial. Thirty participants (18–65 years) with unipolar, non-psychotic MDD will be recruited and randomized to receive 10 sessions of 130 Hz tTIS or sham stimulation (n = 15 per arm). The trial includes a pre- vs. post-treatment 3T MRI scan of the brain, clinical evaluation, and electroencephalography (EEG) acquisition at rest and during the auditory mismatch negativity (MMN) paradigm.

Discussion

This study is one of the first-ever clinical trials among patients with psychiatric disorders examining the therapeutic potential of repetitive tTIS and its neurobiological mechanisms. Data obtained from this trial will be used to optimize the tTIS approach and design a large-scale efficacy trial. Research in this area has the potential to provide a novel treatment option for individuals with MDD and circuitry-related disorders and may contribute to the process of obtaining regulatory approval for therapeutic applications of tTIS.

Clinical Trial Registration

ClinicalTrials.gov, identifier NCT05295888.
Pain, mindfulness, and placebo: a systematic review
Authors: Lopes Alexandra , Sampaio Rute , Tavares Isaura
Published: August 2024

Introduction

Pain is a complex phenomenon influenced by psychosocial variables, including the placebo effect. The effectiveness of mindfulness-based interventions (MBIs) for pain has been demonstrated in experimental studies and systematic reviews, but the mechanisms of action are only starting to be established. Whether the expectations of individuals experiencing pain can be manipulated during MBIs remains to be systematically evaluated, and what role placebo effects might play remains to be explored.

Methods

To evaluate the literature analyzing placebo effects in MBIs for pain, we performed a systematic review based on searches conducted in PubMed, Web of Science, and SCOPUS databases. Our search revealed a total of 272 studies, of which only 19 studies were included (10 acute pain and nine chronic pain), considering the inclusion and exclusion criteria related to expectations and placebo effects.

Results

From the 19 included studies, six measured placebo effects only in relation to the pharmacological intervention used in the study and not to an MBI.

Discussion

The results of the few studies that focused on the placebo effects of the MBIs indicate that placebo and expectations play a role in the MBIs' effects on pain. Although expectations and placebo effects are frequently discussed in the context of mindfulness and pain research, these results show that these factors are still not routinely considered in experimental designs. However, the results of the few studies included in this systematic review highlight a clear role for placebo and expectancy effects in the overall effects of MBIs for both acute and chronic pain, suggesting that routine measurement and further consideration in future studies are warranted. Additional research in this fascinating and challenging field is necessary to fully understand the connection between MBIs, placebo/expectations, and their effects on pain relief.
Rare giant retroperitoneal melanotic schwannoma: a case report and literature review
Authors: Chen Pan , Cheng Junfeng , Zhang Lin
Published: August 2024

Background

Melanotic schwannoma (MS), a rare variant of peripheral nerve sheath tumor, is especially infrequent when originating from the peritoneum. Its definitive diagnosis relies on postoperative histopathological examination and immunohistochemical analysis, while preoperative diagnosis is difficult.

Case presentation

In the present study, we reported a rare case of giant MS in the retroperitoneum, which was previously misdiagnosed before surgery. However, intraoperative exploration revealed it was retroperitoneal tumor. The tumor had invaded the abdominal aorta and bilateral common illiac artery walls. A surgical resection was subsequently executed, and postoperative histopathological examination confirmed it as a MS.

Conclusion

The incidence of peritoneal MS is extremely rare, and surgical resection remains the preferred treatment modality. Given the absence of established guidelines for postoperative adjuvant therapy, long-term follow-up becomes imperative to accumulate valuable clinical expertise.
Landsat-based spatiotemporal estimation of subtropical forest aboveground carbon storage using machine learning algorithms with hyperparameter tuning
Authors: Huang Lei , Huang Zihao , Zhou Weilong , Wu Sumei , Li Xuejian , Mao Fangjie , Song Meixuan , Zhao Yinyin , Lv Lujin , Yu Jiacong , Du Huaqiang
Published: August 2024

Introduction

The aboveground carbon storage (AGC) in forests serves as a crucial metric for evaluating both the composition of the forest ecosystem and the quality of the forest. It also plays a significant role in assessing the quality of regional ecosystems. However, current technical limitations introduce a degree of uncertainty in estimating forest AGC at a regional scale. Despite these challenges, remote sensing technology provides an accurate means of monitoring forest AGC. Furthermore, the implementation of machine learning algorithms can enhance the precision of AGC estimates. Lishui City, with its rich forest resources and an approximate forest coverage rate of 80%, serves as a representative example of the typical subtropical forest distribution in Zhejiang Province.

Methods

Therefore, this study uses Landsat remote sensing images, employing backpropagation neural network (BPNN), random forest (RF), and categorical boosting (CatBoost) to model the forest AGC of Lishui City, selecting the best model to estimate and analyze its forest AGC spatiotemporal dynamics over the past 30 years (1989–2019).

Results

The study shows that: (1) The texture information calculated based on 9×9 and 11×11 windows is an important variable in constructing the remote sensing estimation model of the forest AGC in Lishui City; (2) All three machine learning techniques are capable of estimating forest AGC in Lishui City with high precision. Notably, the CatBoost algorithm outperforms the others in terms of accuracy, achieving a model training accuracy and testing accuracy R2 of 0.95 and 0.83, and RMSE of 2.98 Mg C ha-1 and 4.93 Mg C ha-1, respectively. (3) Spatially, the central and southwestern regions of Lishui City exhibit high levels of forest AGC, whereas the eastern and northeastern regions display comparatively lower levels. Over time, there has been a consistent increase in the total forest AGC in Lishui City over the past three decades, escalating from 1.36×107 Mg C in 1989 to 6.16×107 Mg C in 2019.

Discussion

This study provided a set of effective hyperparameters and model of machine learning suitable for subtropical forests and a reference data for improving carbon sequestration capacity of subtropical forests in Lishui City.
Insights into values and emotional wellbeing of medical students in the United Arab Emirates: a cross-sectional study
Authors: Alhashimi Fatma Mustafa , Salim Sara , Siddiqi Warda , Jeyaseelan Lakshmanan , Khan Nusrat , Sultan Meshal A.
Published: August 2024

Objective

To describe the difference in values among medical students from a first-year student’ and final year student’ perspective. In addition, it is designed to report associations and trends between personal values and overall emotional states.

Methods

This is an analytical cross-sectional study that involved disseminating an online survey via email to first and final year students at the College of Medicine in Mohammed Bin Rashid University (MBRU) in Dubai, United Arab Emirates in December of 2023. The survey encompassed queries on demographics, the Life Values Inventory (LVI) and the Positive and Negative Affect Schedule (PANAS).

Results

The survey was completed by 84 students. About half of the participants were final year medical students (45/84; 53.6%) with the majority being females (70/84; 83.3%). Positive emotions were positively correlated to various life values, including belonging, scientific understanding, responsibility, and achievement (p < 0.05). When comparing academic years, the scores of the life value of Achievement showed a significant correlation (p = 0.04), with first-year students’ mean (SD) of 12 (2) out of 15 compared to 11 (3) out of 15 for final-year students. Positive Emotions also exhibited a significant correlation (p = 0.006), with first-year students’ mean (SD) 40 (5) out of 50 compared to 36 (7) out of 50 for final-year students.

Conclusion

This study adds to medical education research by exploring values and emotions, shedding light on factors shaping students’ professional identities. Understanding these dynamics can aid in supporting future healthcare providers and by extension the patients for whom they care.