bluuebunny/crossref_metadata_2025 huggingface dataset:
Withdrawn: Acceptability and Concerns Towards Covid -19 Vaccination among Parents; A Cross-Sectional Survey in Ras Al-Khaimah, United Arab Emirates
Authors: Kundayi Ravi Ramya , Mohamed Ali  Rasheed Huda , Gamal Mohamed Mona
Published: February 2023

The article has been withdrawn from the website of The New
Emirates Medical Journal at the request of the authors.

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Neurodevelopmental Outcome at 3 Years of Age in Very Low Birth
Weight Infants According to Brain Development and Lesions
Authors: Malova Mariya , Parodi Alessandro , Severino Mariasavina , Tortora Domenico , Calevo Maria Grazia , Traggiai Cristina , Massirio Paolo , Minghetti Diego , Uccella Sara , Preiti Deborah , Nobili Lino , Rossi Andrea , Ramenghi Luca Antonio
Published: February 2023

Background:

During the last decades, severe brain lesions affecting very low birth weight (<1500 gr, VLBW) infants were gradually substituted by milder lesions with debatable prognoses.

Objective:

The objective of this study is to define type, frequency and 3 years of neurodevelopmental outcome of prematurity-related brain lesions in a modern cohort of VLBW infants.

Methods:

VLBW infants admitted to our NICU in 5 years period with brain MRI at term-equivalent age were included. MRI scans were reviewed to identify and grade white matter lesions (WML), intraventricular hemorrhage (IVH), and cerebellar hemorrhage (CBH). Linear measurements of brain size, biparietal width (BPW) and trans-cerebellar diameter (TCD) were carried out. Total maturation score (TMS) was calculated. Developmental Coefficients (DQ) on Griffiths Scale at 3 years of age were compared between patients with different types and grades of lesions and patients without lesions; possible correlations between linear brain measurements, brain maturation and outcome were explored.

Results:

Study included 407 patients. Of them, 187 (46%) had at least one brain lesion on MRI, while 37 (9%) had severe lesions. The most frequent lesion was IVH (28%), followed by WML (21%) and CBH (17%). Mild and severe IVH, moderate and severe WML and all grades of CBH were related to worst outcome at 3 years. In patients without lesions, small BPW and small TCD were associated with worse outcomes. No correlations were observed between TMS and outcome.

Conclusion:

We have observed that even mild brain lesions have a negative influence on neurological outcome at 3 years of age.
The Disruption of Retroperitoneal Interdigitating Dendritic Cell Sarcoma
with Neurogenic Neoplasm as a Result of Immunohistochemical Markers
and Radiological Features
Authors: Anil Pehlivan Umur , Eren Erdogan Kivilcim , Tugsan Balli Huseyin , Erdogan Seyda
Published: February 2023

Introduction:

Retroperitoneal localization is an extremely rare presentation of interdigitating
dendritic cell sarcoma (IDCS), the primary neoplasm of the antigen-presenting interdigitating dendritic
cells.

Case Presentation:

We report an incidentally found isolated retroperitoneal IDCS in a 59-year-old
female patient with no prior symptoms. The patient was initially misdiagnosed since the tissue samples
obtained by tru-cut biopsies were diffusely positive for S-100, and the radiological features were similar
to neurogenic tumors. However, additional immunohistochemical staining in the excisional biopsy
specimen revealed IDCS as the correct diagnosis.

Conclusion:

The correct diagnosis may not always be achieved with tru-cut biopsy evaluations in the
retroperitoneal masses. Immunophenotyping and radiological features can occasionally be perplexing.
In these cases, an accurate diagnosis can be achieved by excisional biopsy and additional immunohistochemical
staining.
Europe In The World Circa 2030
Authors: Gaspar Vitor , Amaglobeli David
Published: February 2023

This article will examine how several underlying evolutionary dynamics will shape the global economy, from a European perspective. The article will also discuss some areas of multilateral cooperation focusing on climate change, the pandemic preparedness, and sustainable development. At a time of heightened geopolitical tensions, international cooperation is key to avoid fragmentation and aggravating instability in the global economy.
A Study on the Perinatal Outcomes of Natural Childbirth Led by Midwives: A Retrospective Study
Authors: An Mi Young , Park Jum Mi , Kim Yun Mi , Chung Hwan Wook , Bang Uri
Published: February 2023

Purpose: The purpose of this study was to suggest the importance of natural childbirth by investigating the results of midwife-led perinatal periods and whether they were positive experiences for both individual women and their families.Methods: This retrospective study aimed to confirm the perinatal outcomes of midwife-attended vaginal births. Among 1,127 women who gave midwife-led birth in Gyeonggi-do, Seoul between January 1, 2019 and December 31, 2021, data were collected for 829 women. Records were excluded that were missing necessary data. Data on childbirth were analyzed using frequency, percentage, mean, standard deviation, and the chi-square test.Results: Among the mothers who underwent natural childbirth, 549 (66.2%) were multiparous. In addition, all 829 patients (100%) breast-fed their infants. First-degree perineal lacerations occurred in 29.2% of patients, and second-degree lacerations occurred in 48%. Non–high-risk subjects made up 56.0% of the study sample. The average bleeding amount was 281.44±4.50, and the average 1-minute Apgar score for infants was 8.25±0.02.Conclusion: Compared to childbirth in a hospital, natural childbirth was associated with a lower risk of birth canal laceration, postpartum bleeding, and Cesarean section. In addition, the health statuses of the newborns were confirmed to be good . Based on the results of this study, there is a need for a strategy in which midwife-led natural childbirth is integrated into the local medical system, as well as a need to raise women's awareness of natural childbirth and positively influence the experience.
The Childbirth Experience and Life Satisfaction among Women with Disabilities
Authors: Ma Su-Bin , Choi Young-Min , Lee Minyoung , Jeon Boyoung
Published: February 2023

Purpose: The aim of this study was to show the association between the childbirth experience and life satisfaction among women with disabilities and estimate the moderating effect of family strengths and social support.Methods: The target sample included disabled married women aged 20-49 years. We used the Disability and Life Dynamics Panel 2018. The total number of participants was 220. Three groups were defined based on the childbirth experience: women who had never given birth (13.6%), those who gave birth before the onset of disability (73.2%), and those who gave birth after the onset of disability (13.2%). We identified differences in general characteristics, family strengths, social support, and life satisfaction across the 3 groups and examined the moderating effect of family strengths and social support for the childbirth experience and life satisfaction.Results: Women who gave birth after the onset of disability were in better health, exhibiting longer disability retention periods. The multiple regression analysis revealed that among women who gave birth after the onset of disability, life satisfaction was significantly higher than that of women without the childbirth experience because of the moderating effect of family strengths. However, social support had no significant effect on the childbirth experience and life satisfaction.Conclusion: We empirically analyzed the status of childbirth before and after the onset of disability using representative survey data. The findings indicate a positive moderating effect of family strengths on the level of life satisfaction among women with disabilities.
Pengaruh Kepemimpinan Transformasional Terhadap Keterlibatan Kerja (Work Engagement) Guru Selama Pelaksanaan Pembelajaran Tatap Muka Terbatas di SDN Karangmojo Yogyakarta
Authors: Arifin Ahmad Syamsul , Jannah Siti Naimatul
Published: February 2023

The rapidly changing of learning models that occur during the COVID-19 pandemic can make teachers more vulnerable to various mental health disorders, thereby decreasing their morale and performance. The transformative leadership style of a school principal is believed to have an influence on changing attitudes, beliefs, and behavior of subordinates to a higher level of motivation. This study aims to determine the effect of principal's leadership on work engagement at SD N Karangmojo Bantul Yogyakarta. The sample of this study involved all teachers who teach at the school. Data collection instruments were adapted from the TLS-Transformation Leadership Survey and the Utrecht UWES-Work Engagement Scale. Based on the results of the regression test, the F count value was 12,933 with a significance level of 0.00 > 0.05. These results indicate that there is a positive and significant effect of the transformational leadership style variable to the work engagement of teachers.

Keyword: Transformational Leadership, Work Engagement, Limited Face-to-Face Learning.
Peran Pendampingan Kerabat Di Masa Pandemic Covid Dalam Meningkatkan Motivasi Belajar Anak Usia Sekolah Dasar
Authors: Khotijah Siti , Kusumawati Putri Rahadian Dyah
Published: February 2023

Implementation and transition of learning systems, changes in learning methods due to the Covid-19 pandemic require adaptation of all elements in education. The busyness of parents in working and taking care of the household causes children not to get full guidance. This causes children's activities and children's enthusiasm for learning to be out of control by parents. Parents take the initiative and on the basis of family concerns, relatives as the child's second closest person provide assistance. This study aims to determine the role, positive impact of family assistance in increasing the learning motivation of elementary school-age children in Pekalongan Regency. The chosen research approach is descriptive qualitative research and uses field qualitative research. Data obtained from observation, interviews and documentation. Sources of data come from student, family relatives, and parents. Data analysis techniques include data reduction, data presented and concluded. Based on the results of research on the role of accompanying relatives in increasing learning motivation, relatives act as supervisors, role as learners, role as advisors and directors. Furthermore, the positive impact of mentoring is to strengthen brotherhood, children feel cared for, children become enthusiastic about learning, and mentoring/supervision by relatives helps parents

 

Keyword: covid19, family assistance, learning motivation, elementary school children
Definisi Dan Teori Pendekatan, Strategi, Dan Metode Pembelajaran
Authors: Ramdani Nanang Gustri , Fauziyyah Nisa , Fuadah Riqotul , Rudiyono Soleh , Septiyaningrum Yayang Alistin , Salamatussa'adah Nur , Hayani Aida
Published: February 2023

Education is a learning activity carried out by the education component to increase the potential of students in various ways. Approach can be interpreted as a point of view on a learning process, has several types and ways of implementation. Learning strategy is the art of using a plan to achieve learning objectives consisting of methods and techniques or procedures. In the strategy there are several learning components and several elements that must be met. While the method is a way to achieve educational goals. Learning methods can be carried out with lectures, discussions, questions and answers, demonstrations, experiments, recitations and field trips. Of course, each method has advantages and disadvantages.

Keyword:  Education, Approach, Strategy, Method.
Pendidikan Islam Dalam Keluarga (Islamic Home Schooling)
Authors: Rouzi Kana Safrina , Afifah Ni’mah , Yarni Linda , Widiyanti Remita
Published: February 2023

The purpose of writing this article is to describe the factors of child development that are integrated with Islamic education through the application of the verses of the Qur'an which contain the upbringing of the Prophets. This research method uses text study. The nature of this research is descriptive research analysis with an idealistic pattern in reducing the verses of the Qur'an and other literature to find solutions to research problems. The results of the study found that Islamic education in the family produces children who are Islamic in spirit and socially competent which is carried out by: (1) setting a good example for children by showing and giving examples of doing good deeds, saying kind words, giving warmth and caring and encouraging children's freedom within reasonable limits, (2) giving good advice to children, by involving children in discussions about current events and then inserting advice in the form of prohibitions on doing all actions that are prohibited by religion, and (3) giving habituation of positive things consistently by applying habits in worship and actions that contain Islamic values (akhlak karimah).

Keywords: Islamic Home Schooling, Developmental Psychology, Islamic Education
The effects of prehabilitation on the functional status of patients undergoing total joint arthroplasty: A Literature Review
Authors: Sunaryanti Almira Yuni , Masfuri Masfuri
Published: February 2023

Background: Total Joint Arthroplasty (TJA) has been proven as the common procedure for end-stage disease in both hip and knee OA. TJA surgery is usually elective. There is a long waiting time between the diagnosis and the surgery, creating a potential for functional decline during the preoperative period that makes a greater effect of disease severity on postoperative result. Therefore, preoperative management is important in TJA preparation in allowing an opportunity window to improve function in patients waiting for TJA surgery and improve postoperative functional recovery. Preoperative exercise programs, known as prehabilitation, have been studied to improve results, before and after surgery. The implementation of prehabilitation before TJA in the recent literature has been shown has many benefits to improve functional status

Objectives: This literature review sought to assess the effects of prehabilitation on the functional status of patients undergoing TJA.

Methods: This review made use of articles obtained through online search on the database of EBSCO, Science Direct, Proquest, and Scopus, with inclusion criteria having full text, published in 2016-2021, and written in English which then matched with certain specific keywords to get the appropriate article.

Results: A total of 7 selected articles have been reviewed in accordance with the search objectives and the results are presented in tabular form. The results of the article indicate that the participants in this study consisted of patients who underwent TKA or THA.

Conclusions: Based on a review conducted on selected articles, it was revealed that prehabilitation provides several benefits including increasing muscle strength, increasing ROM, reducing pain, reducing hospital stay duration, and allowing faster physical and functional recovery after TJA surgery.

 
Description of the usefulness and ease of use wireless stethoscope for auscultation: A pilot study
Authors: Prawira Ricky , Ismail Suhartini , Johan Andrew , Ismail Rifky
Published: February 2023

Background: A stethoscope is an acoustic medical device commonly utilized for listening to internal sounds in the human body. Since its invention, the stethoscope has undergone several transformative improvements, including the introduction of electronic systems in the last two decades. Through the Center of Excellence in the Higher Education of Science and Technology (PUI-PT), Center for Bio Mechanics, Bio Material, Bio Mechatronics, and Bio Signal Processing (CBIOM3S), the Diponegoro University has developed a wireless stethoscope to enable the user to examine the patients quickly without being constrained by tubing, unlike the manual stethoscope. The wireless stethoscope supports health workers in performing their work. This new technology creates various perceptions from its users, one of whom is nurses.

Objectives: This study aims to provide an overview of nurses' perceptions regarding the usefulness and ease of use of a wireless stethoscope to perform auscultation of the heart and lungs of critically ill patients.

Methods: The research method employed was a pilot study, and 40 nurses working in the critical care units, including the Intensive Care Unit, High Care Unit, and Stroke Unit in a private hospital in Palembang City, were chosen as respondents for a total sampling technique.

Results: Nurses' perceptions of the ease and usefulness of a wireless stethoscope were measured using the perceived usefulness and perceived ease of use questionnaires. The nurses' perception of the use of wireless stethoscopes exhibited a mean score of 4.27, while the nurses' perception of the ease of use of wireless stethoscopes showed a mean score of 4.35. Those results indicate that nurses in the critical care units accepted wireless stethoscopes in terms of ease of use and usefulness as a device for performing auscultation of the heart and lungs of critically ill patients.

Conclusions: Nurses get new technology like a wireless stethoscope because it can work more quickly and is easy to use thereby assisting nurses in conducting cardiac and pulmonary auscultation in critical patients.
Audio selfhypnosis through smartphone can reduce anxiety in pregnant women
Authors: Lisnawati Lisnawati , Widiyanti Rani
Published: February 2023

Background: Physical and psychological changes require adaptation to lifestyle adjustments with the pregnancy process that occurs. Problems in pregnancy can be a trigger for emotional reactions that are mild, severe to high levels. Some pregnant women have experienced nausea, vomiting, anxiety, or some have experienced pregnancy comfortably, without complaints. These different responses are influenced by factors: physical, perception, experience, education, emotion and family support. Of these several factors, thoughts and emotions dominate the response to pregnancy. Hypnosis is an effective communication method for incorporating new information or ideas into one's subconscious mind. Audio selfhypnosis in pregnancy, it is hoped that the discomfort in the form of anxiety felt by pregnant women due to direct and indirect factors can be minimized so that it can reduce the incidence of complications during pregnancy, childbirth and the postpartum period.

Purpose: to find out the use of audio self-hypnosis has an effect on reducing discomfort in the form of anxiety in pregnant women.

Method: Using quasi-experimental. The population is all pregnant women at the Majasem Health Center in 2021. Sampling is done by purposive sampling technique, namely 30 pregnant women who are divided into 3 classes of pregnant women. Respondents were first guided on how to do self-hypnosis, then were given audio self-hypnosis via a smartphone to practice at home once every day for 1 week. Anxiety was measured using a questionnaire before and after self-hypnosis. The analysis technique uses paired sample t test. Data is not normally distributed, bivariate analysis using Wilcoxon test.

Results: The analysis showed that there was an effect of using audio self-hypnosis in reducing anxiety in pregnant women with a p value of 0.000.

Conclusion: The use of self-hypnosis audio can reduce discomfort in the form of anxiety in pregnant women
The relationship between providing health videos and knowledge of pregnant women in the Covid-19 era at the Sedayu II Health Center in Yogyakarta
Authors: Noviyani Noviyani , Fatimah Fatimah , Rahman Taufik , Ayuningrum Lia Dian , Delia Amanah Rahma
Published: February 2023

Background : Pregnant women and their fetuses are a priority for high-risk populations during an outbreak of an infectious disease. Pregnancy will naturally cause a decrease in the immune system, especially during the Covid-19 pandemic which can cause excessive anxiety, stress, and exposure to corona virus infection. Several studies state that the use of smartphones has high effectiveness as a medium for health education because they can convey information through audiovisuals, have high portability, and have applications that support improving the quality of health services. Previous research has shown that pregnant women still have a low understanding of Covid-19 prevention regarding efforts to prevent COVID-19 infection

Objectives : The purpose of providing health education through videos to pregnant women is to increase knowledge about covid in pregnancy

Methods : in this study, the population was all trimester I, II, and III pregnant women who performed ANC at the Sedayu II Health Center in June 2020, totaling 30 pregnant women. Provided educational videos which were sent via WhatsApp to each respondent. The pretest and posttest were sent via Google form and data analysis used the Wilcoxon test.

Results : Research shows that there is a significant relationship between providing educational videos about pregnancy and the knowledge of pregnant women about Covid-19 in Bantul. Health education using videos and online utilization is the main choice during the COVID-19 pandemic to prevent increased morbidity and mortality of mothers and newborns.Providing educational videos is considered effective because health workers can still provide KIE to patients by avoiding direct contact to prevent transmission of the corona virus. Pregnant women can be guided to learn about pregnancy and childbirth through MCH books. All of these approaches can contribute to a comfortable pregnancy, reduced risk of infection, better preparedness for labor, maternal experience, postpartum adjustment and outcomes, and greater economic benefits for the health system and the pregnant woman herself.
Conclusions : The results of this study indicate that the use of online video-based educational media is recommended as an alternative method and is considered very appropriate for use during a pandemic
Mobile Mental Health in Women’s Community-Based Organizations: Protocol for a Pilot Randomized Controlled Trial
Authors: Bhat Amritha , Goud B Ramakrishna , Kalidindi Bharat , Ruben Johnson Pradeep , Devadass Dhinagaran , Waghmare Abijeet , Collins Pamela Y , Raj Tony , Srinivasan Krishnamachari
Published: February 2023

Background

Of every 10 women in rural India, 1 suffers from a common mental disorder such as depression, and untreated depression is associated with significant morbidity and mortality. Several factors lead to a large treatment gap, specifically for women in rural India, including stigma, lack of provider mental health workforce, and travel times. There is an urgent need to improve the rates of detection and treatment of depression among women in rural India without overburdening the scarce mental health resources.

Objective

We propose to develop, test, and deploy a mental health app, MITHRA (Multiuser Interactive Health Response Application), for depression screening and brief intervention, designed for use in women’s self-help groups (SHGs) in rural India.

Methods

We will use focus groups with SHG members and community health workers to guide the initial development of the app, followed by iterative modification based on input from a participatory design group consisting of proposed end users of the app (SHG members). The final version of the app will then be deployed for testing in a pilot cluster randomized trial, with 3 SHGs randomized to receive the app and 3 to receive enhanced care as usual.

Results

This study was funded in June 2021. As of September 2022, we have completed both focus groups, 1 participatory design group, and app development.

Conclusions

Delivering app-based depression screening and treatment in community settings such as SHGs can address stigma and transportation-related barriers to access to depression care and overcome cultural and contextual barriers to mobile health use. It can also address the mental health workforce shortage. If we find that the MITHRA approach is feasible, we will test the implementation and effectiveness of MITHRA in multiple SHGs across India in a larger randomized controlled trial. This approach of leveraging community-based organizations to improve the reach of depression screening and treatment is applicable in rural and underserved areas across the globe.

International Registered Report Identifier (IRRID)

DERR1-10.2196/42919
La configuración del derecho a la desconexión digital del trabajo en Chile y su vulneración
Authors: Monteiro Pessoa Rodrigo
Published: February 2023

El derecho a la desconexión del trabajo, que surgió como un nuevo derecho laboral para hacer frente a los cambios en la sociedad del trabajo, tan afectada por la tecnología de la información, y que trae consecuencias nefastas para la vida y la salud de los trabajadores, fue positivado en Chile por la ley 21.220 de 2020. No obstante, dejó muchas lagunas sobre su configuración y sobre la forma como se puede vulnerar este derecho laboral. Este trabajo pretende argumentar sobre estas líneas jurídicas, de forma de ofrecer contribuciones a la aplicación práctica del derecho a la desconexión digital del trabajo en las empresas y por la jurisprudencia, para los casos de conflictos entre las partes de la relación laboral.
Ley Agraria a tres décadas de su entrada en vigor
Authors: López Hernández Edwin
Published: February 2023

El derecho agrario en México se elevó a rango constitucional por primera vez en la Constitución Política de los Estados Unidos Mexicanos promulgada el 5 de febrero de 1917. Desde ese momento ha tenido diversas legislaciones reglamentarias del artículo 27 de nuestra carta magna. Con el paso del tiempo la regulación y figuras jurídicas se han modificado con el objetivo de adecuarse a la actualidad del ser humano.

La Ley Agraria vigente entró en vigor el 27 de febrero de 1992, y si bien ha sido objeto de varias reformas, no menos cierto es que a tres décadas de su publicación se considera necesario contar con una nueva ley que no sólo regule la situación actual del campo mexicano, sino que marque las pautas y encamine a nuestra sociedad hacia el futuro. Este estudio tiene como finalidad analizar la Ley Agraria vigente, específicamente en su regulación sustantiva, y realizar algunas reflexiones en torno a la situación actual de la justicia agraria en este país.
Posibilidades y límites de la reforma laboral en México
Authors: Foust Rodríguez David , Román Morales Luis Ignacio , Álvarez Rodríguez Miguel Ángel
Published: February 2023

El marco institucional de las relaciones laborales en México ha sufrido cambios significativos recientemente. Algunos de los más relevantes son la implementación de una política de recuperación de los salarios mínimos, la ratificación del Convenio 98 de la OIT y la reforma laboral integral. ¿En qué medida esta reforma laboral puede modificar las relaciones laborales en México? ¿Podrán los trabajadores ejercer sus derechos de libertad sindical y de negociación colectiva sin temor a represalias?

Este artículo aborda estas preguntas. A partir de un análisis de casos recientes del movimiento obrero y de las implicaciones de la reforma laboral, se ofrece un marco teórico y un esbozo de investigación futura para su discusión.
Acoso sexual en Chile y tutela judicial efectiva: algunos nudos críticos desde la perspectiva de género
Authors: Domínguez Montoya Álvaro , Gauché Marchetti Ximena , Bustos Ibarra Cecilia , Pérez Díaz Cecilia
Published: February 2023

El presente trabajo se centra en el tránsito histórico, político y regulatorio de la figura del acoso sexual laboral en Chile, enfocando su estudio desde una perspectiva de género a partir de un análisis doctrinario y jurisprudencial. El propósito es evidenciar problemáticas y deficiencias en la regulación del acoso sexual laboral, con la finalidad de proponer y sustentar alternativas de solución desde la tutela judicial efectiva y los derechos fundamentales como eje central. La metodología utilizada para abordar el objetivo principal y los objetivos específicos de esta investigación consistió en un estudio analítico y sistemático de fuentes normativas y doctrinarias. Respecto de la jurisprudencia citada, se utilizó una muestra intencional de sentencias paradigmáticas y de relevancia, que nos parecieron más idóneas para los objetivos de esta investigación, centrándose en un análisis de contenido cualitativo de texto.
Aplicaciones informáticas de economía colaborativa y el derecho del trabajo en Colombia
Authors: Torres Bernal Gladys Carolina , Fonseca Alfonso Yair Leonardo
Published: February 2023

A raíz del auge de aplicaciones de economía colaborativa, se ha multiplicado la prestación de servicios a través de medios diversos al clásico contrato de trabajo, lo que genera altos niveles de informalidad e inestabilidad en el empleo. Así, el presente artículo de reflexión tiene dos objetivos: plantear un análisis crítico-propositivo acerca de las nuevas tendencias de contratación por medio de mecanismos divergentes al tradicional contrato de trabajo, y estudiar a profundidad el impacto de estas nuevas formas de vinculación y sus consecuencias sobre el derecho del trabajo en Colombia. A partir de lo anterior, se plantea como hipótesis de investigación la identificación de características que permitan establecer la existencia de una verdadera relación laboral en el marco de las nuevas formas de economía colaborativa, que operan por medio de aplicaciones digitales, bajo el amparo de normas internacionales del trabajo y de principios constitucionales que permitan generar un piso de protección al trabajador, dentro de un espíritu de unicidad del derecho. Finalmente, se destaca como principal resultado investigativo la propuesta de una reconfiguración jurídica para proteger a las personas que prestan servicios mediante aplicaciones informáticas.
Role of CO2 Carriers in Carbon Capture Utilization and Sequestration as A Part of Global Decarbonization Strategy
Authors: Binu Karthik , Viswanath Abhishek A. , Raj Maroli Namith
Published: February 2023

Abstract: With the world gearing up to cut down carbon emissions to combat the greenhouse effect, a novel method has been introduced to collect and store co2 after pressurizing and liquifying it. carbon sequestered will either be put to use in industries or will be buried deep underground. this concept is highly revered due to its pragmatism and simplicity and is broadly termed as "carbon capture, utilization and sequestration/ storage (ccus)". though it is clear how to capture, utilize and store liquified co2 (lco2), the modus operandi of transportation remains abstruse. though the technical feasibility of this method is still under debate, many shipping companies have set forth to construct liquified co2 (lco2) tankers. ongoing studies are focused on finding the best methods to transport co2 by retrofitting lng ships to better equip them for storing and transporting co2. this paper takes a systematic approach to review the development of lco2 tankers. it discusses the trail of development, major challenges and limitations, technological gaps, and future prospects. it also looks over the economic and ecological aspects of such an endeavor. the paper has also taken care not to be oblivious to other options at hand, including pipelines and railways. it briefly explains the above methods and further discusses their limitations.
EMERGING DRUGS: A SYSTEMATIC REVIEW OF THE POTENTIAL ANTIVIRAL ACTIONS OF AZITHROMYCIN.
Authors: Corrêa Leonardo Tibiriçá , Peña-Muñoz Juliana Weckx , Waziry Paula Faria , Nicoletti Maria Aparecida , Ricci Esther Lopes , Hirota Vinicius De Barros , Fukushima André Rinaldi
Published: February 2023

INTRODUCTION: Viruses that cause respiratory infections, commonly called "flu," kill thousands of people annually. In 2020, the World Health Organization declared a pandemic state due to COVID-19 infection. The virus that causes COVID-19, SARS-CoV-2, causes acute respiratory syndrome, which currently has no established treatment and is capable of widespread dissemination. OBJECTIVE: Systematically provide evidence of azithromycin’s pleiotropic antiviral effects. METHODOLOGY: Pubmed database search for articles related by the terms: “antiviral” and “azithromycin”. RESULTS: Although there are no clinical protocols that can clearly evaluate the antiviral effectiveness of azithromycin, 73,3% of the articles found concluded that azithromycin has potential pleiotropic antiviral activity that should be further investigated. CONCLUSION: Azithromycin has the potential to be repurposed as an antiviral drug, however, further studies are needed for targeting the drug’s action against specific viral pathogens as well as double-blind, randomized clinical trials.

Keywords: Emerging drugs. Azithromycin. Antiviral. Immunomodulatory effects
Ecotoxicidade aguda dos combustíveis: diesel S10, S500, biodiesel e misturas comerciais utilizando Artemia sp. como indicador
Authors: Brandão Antonio Araãn Jambeiro , Brandão Ana Clara Silva , Paulillo Luis Cesar Maffei Sartini , Dos Santos Taila Tamille , Almeida Gabriel Barroso , Sales Rafael de Lima , Peso-Aguiar Marlene Campos
Published: February 2023

O objetivo deste trabalho foi avaliar a toxicidade aguda das FSA dos combustíveis fóssil S500, S10, Biodiesel, e misturas comerciais (B10), tendo a Artemia sp. como organismo teste. Essa avaliação foi realizada através da exposição de náuplios fase II e III - 48 horas vida, por um período de 24-48h, em concentrações de 5, 10, 22, 46 e 100% de FSA e analisada a CL50 e CL90. Os resultados obtidos demonstram que os combustíveis que apresentaram maior toxicidade foram os fósseis S500 com CL50- 24h 8,5 % de FSA e CL90- 24h 29,4% de FSA, seguido do S10, que apresentaram a mesma concentração de letalidade para o CL50- 24h e CL90- 24h de 12% ± 3, seguido das misturas S10+B100 com CL 50- 24h - 15,2 % de FSA e CL90- 24h 32, 6%, e do S500+B100 com CL 50- 24h 39% de FSA e CL90- 24h 64,7% FSA. O biodiesel não apresentou toxicidade significava na exposição por 24h. Após 48h de exposição, todos os combustíveis apresentaram elevada toxicicidade nos organismos avaliados. Os resultados demonstraram que em 24 horas, os combustíveis mais tóxicos são os fósseis, sendo o S500 mais tóxico que o S10, quando adicionado de biodiesel o S10+B100 torna-se mais tóxico que o S500+B. Após 48h, todos os combustíveis apresentaram toxicidade elevada.
A EXPOSIÇÃO PRÉ-NATAL A PESTICIDAS PODE DESENCADEAR O TRANSTORNO DO ESPECTRO AUTISTA?
Authors: Reis Ivna Leite , Pinheiro Alina Maria Núñez , Bachur Tatiana Paschoalette Rodrigues
Published: February 2023

O transtorno do espectro autista (TEA) é caracterizado por prejuízos no desenvolvimento neurológico e dificuldades no relacionamento social. A etiologia do TEA é multifatorial, influenciada por aspectos genéticos, biológicos e ambientais. O objetivo deste estudo é analisar a literatura recente para verificar a associação entre a exposição pré-natal a pesticidas e o desenvolvimento do TEA a fim de orientar ações de prevenção e pesquisas. O presente artigo de revisão foi desenvolvido a partir de uma pesquisa bibliográfica realizada nos portais de busca PubMed, Biblioteca Virtual em Saúde e Portal de Periódicos CAPES, com a seleção de artigos científicos publicados entre os anos de 2016 e 2020. A literatura analisada aponta evidências de modificações na expressão de genes por fatores ambientais que podem culminar no desenvolvimento do TEA; todavia os mecanismos exatos ainda não são conhecidos. Em animais, a exposição a pesticidas pode determinar alterações no neurodesenvolvimento, apesar de ainda não existir uma relação deste achado ao comportamento humano. A proximidade materna de regiões com ampla administração de praguicidas durante o período gestacional tem sido associada a prejuízo na cognição e na compreensão verbal, risco elevado para TEA e outros déficits intelectuais. Algumas substâncias podem interferir como fator protetor ou agravante da associação entre a ocorrência de TEA frente à exposição de pesticidas. Em suma, os estudos analisados demonstram a possível associação entre a exposição a pesticidas e o desenvolvimento do transtorno do espectro autista, demonstrando que é cada vez mais necessário investigar sobre a etiopatogenia multifatorial do TEA.
O QUINZE: EXCERTO DA LITERATURA BRASILEIRA ACERCA DA INTOXICAÇÃO POR MANIHOT ESCULENTA CRANTZ
Authors: Carmo Filipe Correia , Pinheiro Raul Guilherme Oliveira , Costa Juliana Ciarlini , Bachur Tatiana Paschoalette Rodrigues
Published: February 2023

Rachel de Queiroz (1910-2003) foi uma escritora brasileira que produziu diversas obras literárias, muitas ambientadas no Sertão Nordestino. Seu romance O Quinze retrata a saga de uma família retirante formada por Chico Bento, Cordulina e seus filhos; um deles, Josias, sofre intoxicação aguda por mandioca (Manihot esculenta Crantz) e apresenta vários sintomas referentes à intoxicação. A mandioca, alimento consumido em todo mundo, contém glicosídeos cianogênicos com potencial de formar cianeto de hidrogênio e causar intoxicação. O presente estudo objetivou realizar uma pesquisa bibliográfica sobre os aspectos da intoxicação aguda e crônica provocada pela M. esculenta Crantz fazendo um paralelo com a narrativa de Rachel de Queiroz. Foram selecionados 11 artigos científicos publicados entre 2010 e 2020 na base de dados Medline versando sobre intoxicação por M. esculenta Crantz, além de livros-texto e o livro O Quinze. O cianeto de hidrogênio se forma após a ingestão da mandioca a partir da linamarina e da lotaustralina presentes na planta, sendo metabolizado pelo organismo em tiocianato. A intoxicação aguda cursa com sintomas gerais e pode ser fatal. O tratamento é feito com antídotos como os complexos com cobalto e os oxidantes formadores de metemoglobina. A exposição crônica ao cianeto manifesta-se em síndromes neurológicas, ocorrendo especialmente em países pouco desenvolvidos. Não há tratamento específico para a intoxicação crônica, sendo os métodos de prevenção a medida eficaz para a redução de casos. Não obstante haja literatura científica substancial, mais estudos são necessários para que sejam desenvolvidas novas técnicas de prevenção e tratamento.
ALTERAÇÕES CARDIOVASCULARES EM INDIVÍDUOS QUE ABUSAM DE ESTEROIDES ANABÓLICOS ANDROGÊNICOS
Authors: Feitosa Gabriel Monteiro , Bachur Tatiana Paschoalette Rodrigues
Published: February 2023

Esteroides anabólicos androgênicos são compostos derivados da testosterona e desenvolvidos para tratar diversas condições clínicas, tais como o hipogonadismo sintomático. No entanto, a partir de 1950, passaram a ser usados por atletas de diversas modalidades para a melhora da performance esportiva. Apesar de seu uso clínico apresentar diversos benefícios, o abuso destas substâncias pode provocar efeitos tóxicos para a mente e corpo de seus usuários, a exemplo do aumento do risco da ocorrência de alterações cardiovasculares. A presente pesquisa bibliográfica teve como objetivo realizar um levantamento na literatura acerca das principais alterações encontradas no sistema cardiovascular de indivíduos que utilizam esteroides anabólicos androgênicos de modo abusivo. Foram utilizadas as bases de dados EMBASE e MEDLINE, a partir das quais foram selecionados 18 artigos para compor essa revisão. A análise dos artigos selecionados mostrou que os esteroides possivelmente provocam alterações na pressão arterial, na função e estrutura cardíaca, nos vasos sanguíneos e no mecanismo de coagulação de seus usuários. Porém, são necessários mais estudos com boa metodologia e nível de evidência para estabelecer causalidade entra o abuso de esteroides anabólicos androgênicos e as alterações cardiovasculares.
Dinitrofenol, uma boa sacada ou um risco eminente? Uma revisão de literatura
Authors: Araujo Iago Portolani de , Caperuto Erico Chagas , Santana Jeferson Oliveira , Franca Elias de , Fukushima André Rinaldi
Published: February 2023

Os atletas usam e fazem mau uso de substâncias recreativas para o aumento do desempenho esportivo, pelos mesmos motivos de não atletas. Essas substâncias são utilizadas muitas vezes para o aumento do desempenho esportivo, para melhorar a força, velocidade, agilidade e para diminuir o tempo de fadiga. E uma dessas substâncias é o 2,4-dinitrofenol, uma substância muito utilizado atualmente entre os fisiculturistas. O 2,4-dinitrofenol teve seus estudos iniciados no ano de 1933 e verificou-se que a mesma tinha propriedades emagrecedoras. Já no ano de 1934 mais de 20 empresas já estavam comercializando esta substância devido a suas propriedades de emagrecimento. Todavia no ano de 1938 o uso sem prescrição e nenhum tipo de orientação levaram a muitos casos de intoxicações, a partir disso o 2,4-dinitrofenol foi retirado do mercado.
Integrative Revision about Parental Care and Life History in Canids, with Emphasis on the Chrysocyon brachyurus Species (Illiger, 1815)
Authors: Ricci Esther Lopes , Paula Leonardo Ribeiro , Zanietti Gabriel Augusto , Ribeiro Guilherme Mendes , Siqueira Guilherme Nagliati Conceição , Smith Nickolas Azevedo de , Cardoso Vinicius de Carvalho , Pantaleon Lorena , Faria Beatriz do Prado Paca , Muñoz Juliana Weckx Peña , Fukushima André Rinaldi
Published: February 2023

The canidae are a family of the Mammalia class represented by two extinct subfamilies called Hesperocyoninae and Borophaginae. Also by the still existing subfamily called Caninae which includes all living canids (dogs, wolves, jackals, coyotes and foxes). Divided into 14 genus and 34 species distributed on all continents. They have carnivorous and omnivorous feeding, being pack animals or essentially solitary animals meeting only during the breeding season where many species develop parental care for their offspring. Among these species the maned wolf (Chrysocyon brachyurus) stands out. Being the largest South American canid an omnivorous, generalist and opportunistic species whose diet varies seasonally consuming a great diversity of fruits and small vertebrates. They are widely distributed in the areas of fields and savannahs in the central region of South America. However it is noted that there was a considerable decrease in the original portion of their habitat in addition to the illegal hunting to use the animals' fur being run over on roads and diseases are the most frequent causes that do not contribute to the conservation of this species. Therefore the species is listed in Appendix II of CITES and is considered Vulnerable (VU). As Chrysocyon brachyurus represents one of the main predators of its biome playing a fundamental role for its balance. Its preservation is essential and further studies are needed for better understanding and formation of strategies that contribute to its conservation.
INTOXICAÇÃO EXÓGENA POR DOMISSANITÁRIOS
Authors: Forni de Almeida Giulia , Giovanna R. Boleeiro  , Bianca A. Diz  , Louise T. P. Pimenta  , Walkyria Sigler
Published: February 2023

A intoxicação exógena compreende um conjunto de efeitos nocivos ao organismo produzidos pela interação de um ou mais agentes tóxicos com o sistema biológico, causando um desequilíbrio orgânico. Os casos de intoxicação exógena, em sua grande maioria, são provocados por saneantes domissanitários, principalmente relacionados à ingestão acidental ou proposital. Os produtos usados para a higienização, desinfecção ou desinfestação de áreas domiciliares ou públicas são chamados de domissanitários, e são caracterizados como a terceira maior causa de intoxicação exógena, uma vez que estão voltados para atender as necessidades da população em relação a higienização dos ambientes, utensílios, móveis e outros artigos. As exposições a estes produtos nocivos são mais comuns principalmente em crianças e adolescentes, porém também são frequentes em mulheres adultas. Isto ocorre, em especial, devido a sua apresentação, com embalagens coloridas e características organolépticas como cor, odor e aspecto atrativos, o que desperta a curiosidade das crianças. Outro fator que influencia na ocorrência de casos de intoxicação é o armazenamento e manuseio inadequado do produto, o que pode estar relacionado a não leitura de rótulos e o não uso ou uso inadequado ou insuficiente de Equipamentos de Proteção Individuais (EPI). Vale destacar ainda que o manuseio destes produtos está crescendo frente ao cenário recente de pandemia, com isso o surgimento de acidentes e quadros de intoxicações e de variada expressão toxicológica, têm assumido um destaque no cenário das intoxicações.
Projeto de intervenção para reduzir as intoxicações exógenas por medicamentos em Uberaba, Minas Gerais
Authors: Leopoldino Rízia Carla da Silva , Rodrigues Diego Fernandes , Borges Sarah Clarinda Resende Rodrigues , De Oliveira Stefan Vilges
Published: February 2023

Os medicamentos são a principal causa de intoxicação exógena no Brasil, tendo como principais origens a tentativa de suicídio, ingestão acidental e a automedicação, para tal carecem de intervenções. Objetivo: Descrever o perfil epidemiológico das intoxicações exógenas por medicamentos no município de Uberaba - MG, no período de 2016 a 2021, e propor intervenções para redução desse agravo à saúde. Métodos: Estudo transversal quantitativo, sobre as intoxicações por medicamentos, no município de Uberaba – MG. Foi utilizado como base de dados o Sistema de Informação de Agravos de Notificação - SINAN referente ao período de 2016 a 2021. Para a construção da proposta de intervenção foi realizada revisão sistematizada da literatura com utilização da base de dados “Google Acadêmico” por meio dos indexadores “intoxication” “exogenous” and “drug intoxication“. Foram incluídos artigos em português publicados no período de 2016 a 2021. Foram excluídos os artigos que não possuíam proposta de intervenção e as intoxicações que não foram provocadas por medicamentos. Resultados: Observou-se alta incidência de intoxicações exógenas por medicamentos no município de Uberaba – MG durante o período de 2016 a 2021, sendo observado uma maior proporção de casos em tentativas de suicídio, entre mulheres na faixa etária de 20 a 39 anos, ingestão acidental em crianças na faixa etária de 1 a 4 anos e a automedicação na faixa etária de 20 a 59 anos. Na revisão sistemática foram analisados 10 artigos para a construção da proposta de intervenção, os quais abordaram métodos de intervenção em educação em saúde, acompanhamento psicológico e ampliação dos atendimentos em todos os níveis de atenção á saúde. Conclusão: Este estudo identificou um aumento no número de casos de intoxicação exógena por medicamentos na cidade de Uberaba – MG, principalmente no ano de 2019.