bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhanced Critical Charge (Q cr ) and Highly Reliable Read-Decoupled Radiation-Hardened 14T SRAM cell for Aerospace Application
Authors: Ahirwar Rachana , Pattanaik Manisha , Srivast Pankaj
Published: November 2023

Due to technological advancements, the size of transistors and the spacing between them is decreasing, resulting in a reduction in the critical charge of sensitive nodes. This decrease in critical charge makes these nodes more susceptible to disturbances and errors in static random access memory (SRAM) cells used in aerospace applications. To address this, a proposed 14T SRAM cell with polarity hardening technology is introduced in this paper, which reduces the number of sensitive nodes and enables recovery from single-event-multiple-effect (SEME) based on all single-event upset (SEU) recovery techniques. The simulation results conducted on the United Microelectronics Corporation (UMC) 65 nm CMOS commercial standard process demonstrate that the proposed 14T SRAM cell reduces both SEU and SEME. A comparative study is performed between the proposed 14T cell and other radiation-hardened SRAM cells, including DICE, SAR14T, RSP14T, RHBD14T, and NRHC14T, to assess the relative performance of the proposed cell. The proposed 14T cell for SRAM exhibits 40.42% and 21.39% improvements in write stability compared to existing cells like DICE and RSP14T, as well as 25.08% and 19.09% improvements in read stability compared to RHBD14T and RSP14T. It also shows enhancements of 81.88%, 76.82%, 57.83%, and 10.25% in critical charge value compared to RHBD14T, NRHC14T, SAR14T, and RSP14T, respectively, better stability, and improved overall performance, making it suitable for aerospace applications. Monte Carlo (MC) simulations have verified its ability to recover from SEU and SEME, with zero percent failure probability during read, write, and hold operations at different supply voltages.
Intention to use telemonitoring for chronic illness management and its associated factors among Nurses and Physicians at Public Hospitals in Bahir Dar, Northwest Ethiopia: Using modified UTAUT-2 model
Authors: Alameraw Temesgen Ayenew , Asemahagn Mulusew Andualem , Gashu Kassahun Dessie , Walle Agmasie Damtew , Kelkay Jenberu Mekurianew , Mitiku Abebaw Belew , Dube Geleta Nenko , Guadie Habtamu Alganeh
Published: November 2023

Background: Chronic illnesses require continuous medical attention as well as patient self-management. Telemonitoring has the potential to maximize professional productivity, continuous medical attention and improve patient self-care management as well as reduce hospitalization and cost of care using these applications. Despite all the benefits, little is known about nurses' and professionals’ intentions to use telemonitoring technologies in Ethiopia. Therefore, this study assessed nurses' and professionals’ intention to use telemonitoring and its associated factors in Ethiopia.
Methods: A cross-sectional study was conducted among 781 randomly selected nurses and physicians working at Public Hospitals in Bahir Dar City, Northwest Ethiopia. The sample size was allocated proportionally to each hospital and the profession based on the number of staffs was applied to give a chance for all. A simple random sampling technique was applied to obtain the sample. Trained data collectors collected data using a self-administered questionnaire. Data were entered into Epi-data version 4.6 and exported to SPSS version 25 for further cleaning and descriptive statistical analysis. The extent of the relationship between variables was determined using AMOS 23 structural equation modeling (SEM).
Result:The response rate was 732/781 (93.7%) of them 55.7% (408/732) were male, and two-thirds 67.6 % (495/732) of participants were nurses. The proportion of intention to use telemonitoring was 55.9% with 95.0%: CI: [52.3-59.6]. Performance expectancy (β=0.366, 95% CI: [0.250,0.482]), effort expectancy (β=0.145, 95% CI: [0.053, 0.231]), facilitating condition (β=0.261, 95% CI: [0.146, 0.380]) and habit (β=162, 95% CI: [0.064, 0.262]) has a positive effect on the intention to use telemonitoring. The relationship between effort expectancy and intention to use telemonitoring was positively moderated by age and gender. Being young and males were found to be positive influencers in the relationship. The relationship between facilitating conditions and intention to use telemonitoring was positively moderated by age and significantly associated with adults.
Conclusion More than half of nurses and physicians at public hospitals in Bahir Dar has the intention to use telemonitoring. Performance expectancy, effort expectancy, facilitating condition, and habit were statistically significant factors of intention to use telemonitoring.
Quasi-dynamic opposite learning enhanced Runge-Kutta optimizer for solving complex optimization problems
Authors: Turgut Oguz Emrah , Turgut Mert Sinan
Published: November 2023

The Runge-Kutta Optimization (RUNGE) algorithm is a recently proposed metaphor-free metaheuristic optimizer borrowing practical mathematical foundations of the famous Runge-Kutta differential equation solver. Despite its relatively new emergence, this algorithm has several applications in various branches of scientific fields. However, there is still much room for improvement as it suffers from premature convergence resulting from inefficient search space exploration. To overcome this algorithmic drawback, this research study proposes a brand-new quasi-dynamic opposition-based learning (QDOPP) mechanism to be implemented in a standard Runge-Kutta optimizer to eliminate the local minimum points over the search space. Enhancing the asymmetric search hyperspace by taking advantage of various positions of the current solution within the domain is the critical novelty to enrich general diversity in the population, significantly improving the algorithm's overall exploration capability. To validate the effectivity of the proposed RUNGE-QDOPP method, thirty-four multidimensional optimization benchmark problems comprised of unimodal and multimodal test functions with various dimensionalities have been solved, and the corresponding results are compared against the predictions obtained from the other opposition-based learning variants as well as some state-of-art literature optimizers. Furthermore, six constrained engineering design problems with different functional characteristics have been solved, and the respective results are benchmarked against those obtained for the well-known optimizers. Comparison of the solution outcomes with literature optimizers for constrained and unconstrained test problems reveals that the proposed QDOPP has significant advantages over its counterparts regarding solution accuracy and efficiency.
Particle tracking in snow avalanches with in situ calibrated inertial measurement units
Authors: Winkler Robert , Neuhauser Michael , Neurauter Rene , Erlacher Felix , Steinkogler Walter , Fischer Jan-Thomas
Published: November 2023

In the course of an artificially triggered avalanche, a particle tracking procedure is combined with supplementary measurements, including Global Navigation Satellite System (GNSS) positioning, Terrestrial Laser Scanning (TLS), and Doppler radar measurements. Specifically, an Inertial Measurement Unit (IMU) is mounted inside a rigid sphere and placed in the avalanche track. It is entrained by the moving snow, measuring translational accelerations, angular velocities, and the flux density of Earth’s magnetic field. Based on this data, we present a threefold analysis: (i) a qualitative data interpretation, identifying different particle motion phases which are associated to corresponding flow regimes, (ii) a quantitative time integration algorithm, determining the corresponding particle trajectory and associated velocities on the basis of standard sensor calibration, and (iii) an improved quantitative evaluation relying on a novel in situ sensor calibration technique, which is motivated by the limitations of the given data set. The final results, i.e. the evolution of the angular orientation of the sensor unit, translational and rotational velocities, and estimates of the sensor trajectory, are assessed with respect to their reliability and relevance for avalanche dynamics as well as for future design of experiments.
Maria Bamberg, 1915–2016
Authors: Kelletat Andreas F.
Published: November 2023

Maria Bamberg lebte mehrere Jahrzehnte in Argentinien. In den 1930er Jahren absolvierte sie an der Universität Córdoba eine Ausbildung als Lehrerin sowie als Übersetzerin für Deutsch und Englisch, verdiente sich wohl auch "einige Brötchen mit medizinischen Übersetzungen, meist aus dem Englischen". 1963 kehrte sie mit ihrem Mann nach Deutschland zurück und widmete sich als "übersetzende Hausfrau" mit beachtlichem Erfolg der Vermittlung argentinischer, mexikanischer und venezolanischer Gegenwartsliteratur.
Johannes Bobrowski : Bibliographie der Nachdichtungen
Authors: Kelletat Andreas F.
Published: November 2023

Die Bibliographie stützt sich auf die entsprechenden Nachweise in der sechsbändigen Ausgabe der "Gesammelten Werke" (1987 u. 1998/99) sowie der vierbändigen Ausgabe der "Briefe 1937-1965" von 2017. Ergänzend wurden Eberhard Haufes "Bobrowski-Chronik" (1994) sowie der Katalog der Deutschen Nationalbibliothek konsultiert.
ANTIHYPERTENSIVE AND ANTIDIABETIC PEPTIDES DERIVED FROM IN SILICO SIMULATED GASTROINTESTINAL DIGESTION OF QUINOA (Chenopodium quinoa) GLOBULINS AND MOLECULAR DOCKING STUDY
Authors: Chirinos Rosana , Rodriguez-Diaz Jamerccy , Anticona Sebastian , Aguilar-Galvez Ana , Pedreschi Romina , Campos David
Published: November 2023

This study evaluated the impact of in silico simulated gastrointestinal digestion (GID) of four quinoa globulins on the potential to release ACE and DPP-IV inhibitor peptides (antihypertensive and antidiabetic properties, respectively), as well as performed a molecular docking study to evaluate the interactions produced in the peptide-enzyme complexes. In silico GID performed on quinoa globulins resulted in the formation of amino acids as well as peptides with two to five residues. The peptides PSF, IPG, CSG, SPR, CSPG and PPN stood out for their high bioactivity scores (> 0.6), for not showing toxicity, as well as presenting potential inhibitory properties to both ACE and DPP-IV enzymes evaluated by ToxinPred, PeptideRanker and BioPep tools, respectively. The molecular docking analysis allowed highlighting that all peptides interacted with the enzymes, finding favorable binding energy values, different number and type of interactions, either at the level of the enzyme active sites or not, characteristics that together would define the potential of the established interaction of the complexes formed. The results, at the level of a first screening, support that GID of quinoa globulins can give rise to peptides with both antihypertensive and antidiabetic properties, requiring further in vitro and in vivo studies.
Positive Youth Development in Colombia: Reflections on a Cross-cultural Collaboration
Authors: Dodd Sara , Moratto Vásquez Nadia , Vélez Gomez Paulina , Sánchez Acosta Daniela , Gonzales Gloria
Published: November 2023

This paper shares the story and reflections of an international collaboration aimed at cross-culturally adapting the United Future Leaders (UFL) program, originally developed in the United States (U.S.), for Colombian youth. The paper provides a comprehensive description of how the collaboration has unfolded from three perspectives: Conceptual (theoretical), functional (program adaptation), and reflective (insights from the collaboration team). Rooted in Lerner’s and Lerner’s Positive Youth Development model, UFL provides participants with an active learning experience focused on developing leadership competencies that promote the development of character, ethics, and civility. For the adaptation study, two schools (one public and one private) were chosen to represent the general population of the city of Medellín (Colombia). The paper describes how UFL is delivered in the U.S., the research activities that were undertaken to ensure methodological rigor for the adaptation process and the content and implementation of the pilot activities. Subsequently, the collaboration team reflects on the different perceptions and understandings of what it means to establish a PYD program such as UFL in Medellin, Colombia. Finally, it is discussed how adapting and implementing programs guided by PYD principles is a promising approach for Colombian youth.
Water quality status and challenges in India and Nepal
Authors: Balkhi Syed Arwa A. , Karki Bhesh Kumar , Philip Ligy , Maliyekkal Shihabudheen M.
Published: November 2023

Water is a life-sustaining sector, and adequate access to safe water is fundamental to a healthy life and driving countries’ economic growth. It is an endowment from nature that must be protected and defended. However, the gross negligence and mismanagement of the water bodies, poor sanitation facilities, improper handling of liquid and solid wastes, and uncontrolled population growth pose a severe threat to the freshwater sector in developing economies like India. The widespread presence of healthcare products, pharmaceutically active compounds, and similar unregulated compounds in freshwater is an emerging concern due to their increasing societal dependence. These pollutants are causing additional threats to the dwindling freshwater reserves and posing significant challenges to achieving water quality objectives. The frequency of occurrence of geogenic pollutants, including radioactive pollutants, is also increased due to anthropogenic factors. Though various measures have been taken to address the problem, lack of planning, regulatory guidelines, poor institutional framework, and corruption have hampered the beneficial outcome. As a result, many underprivileged people from rural and urban areas in India and other nations in the Global South still lack access to safe drinking water. Considering the complexity of the problem, a comprehensive approach is needed to improve the existing condition and provide safe water to everyone. This chapter reviews various challenges pertaining to water quality in India and Nepal and solutions to obtain water quality objectives in a sustainable way.
Smart water network infrastructures
Authors: Gabbar Hossam A. , Islam Sultan , Ramadan Ahmed
Published: November 2023

This paper presents a solution to convert the conventional water network into a smart water network (SWN). Scenarios are synthesized for water recycling inside buildings with less water consumed, minimizing the overall cost. Multiphysics modelling and simulation are conducted with Hysys and Ansys - Fluent in calculating the water flow quantity, pressure of the water network and velocity of water inside the pipe network. Four scenarios are synthesized and modelled for a selected mall building case study. These scenarios reduce the water consumption in the mall from 100% to 29.4%, with a cost-saving of more than 60%.
Exploring the Targets of Dengue Virus and Designs of Potential Inhibitors
Authors: Nath Sayan , Malakar Piyali , Biswas Baisakhi , Das Suryatapa , Sabnam Nahid , Nandi Sisir , Samadder Asmita
Published: November 2023

Background:

Dengue, a mosquito-borne viral disease spread by the dengue virus
(DENV), has become one of the most alarming health issues in the global scenario in recent
days. The risk of infection by DENV is mostly high in tropical and subtropical areas of the
world. The mortality rate of patients affected with DENV is ever-increasing, mainly due to a lack
of anti-dengue viral-specific synthetic drug components.

Introduction:

Repurposing synthetic drugs has been an effective tool in combating several pathogens,
including DENV. However, only the Dengvaxia vaccine has been developed so far to
fight against the deadly disease despite the grave situation, mainly because of the limitations of
understanding the actual pathogenicity of the disease.

Methods:

To address this particular issue and explore the actual disease pathobiology, several
potential targets, like three structural proteins and seven non-structural (NS) proteins, along with
their inhibitors of synthetic and natural origin, have been screened using docking simulation.

Results:

Exploration of these targets, along with their inhibitors, has been extensively studied in
culmination with molecular docking-based screening to potentiate the treatment.

Conclusion:

These screened inhibitors could possibly be helpful for the designing of new congeneric
potential compounds to combat dengue fever and its complications.
Clodronic Acid has Strong Inhibitory Interactions with the Urease Enzyme of Helicobacter pylori: Computer-aided Design and in vitro Confirmation
Authors: Fath Mohsen Karami , Khalili Saeed , Boojar Masoud Mashhadi Akbar , Hashemi Zahra Sadat , Zarei Mahboubeh
Published: November 2023

Background:

Helicobacter Pylori (HP) infection could lead to various gastrointestinal
diseases. Urease is the most important virulence factor of HP. It protects the bacterium
against gastric acid.

Objective:

Therefore, we aimed to design urease inhibitors as drugs against HP infection.

Methods:

The DrugBank-approved library was assigned with 3D conformations and the structure
of the urease was prepared. Using a re-docking strategy, the proper settings were determined
for docking by PyRx and GOLD software. Virtual screening was performed to select the
best inhibitory drugs based on binding affinity, FitnessScore, and binding orientation to critical
amino acids of the active site. The best inhibitory drug was then evaluated by IC50 and the diameter
of the zone of inhibition for bacterial growth.

Results:

The structures of prepared drugs were screened against urease structure using the determined
settings. Clodronic acid was determined to be the best-identified drug, due to higher
PyRx binding energy, better GOLD FitnessScore, and interaction with critical amino acids of
urease. In vitro results were also in line with the computational data. IC50 values of Clodronic
acid and Acetohydroxamic Acid (AHA) were 29.78 ± 1.13 and 47.29 ± 2.06 μg/ml, respectively.
Diameters of the zones of inhibition were 18 and 15 mm for Clodronic acid and AHA, respectively.

Conclusion:

Clodronic acid has better HP urease inhibition potential than AHA. Given its approved
status, the development of a repurposed drug based on Clodronic acid would require less
time and cost. Further, in vivo studies would unveil the efficacy of Clodronic acid as a urease
inhibitor.
Anticancer Potential of Novel Cinnamoyl Derivatives against U87MG and SHSY-5Y
Cell Lines
Authors: Gouleni Niki , Di Rienzo Annalisa , Oner Sena , Karagöz Ceren , Arslan Mehmet Enes , Mardinoglu Adil , Turkez Hasan , Di Stefano Antonio , Vassiliou Stamatia , Cacciatore Ivana
Published: November 2023

Background:

Glioblastoma multiforme (GBM) is probably the most malignant and aggressive brain
tumor belonging to the class of astrocytomas. The considerable aggressiveness and high malignancy of GBM
make it a tumor that is difficult to treat. Here, we report the synthesis and biological evaluation of eighteen novel
cinnamoyl derivatives (3a-i and 4a-i) to obtain more effective antitumor agents against GBM.

Methods:

The chemical structures of novel cinnamoyl derivatives (3a-i and 4a-i) were confirmed by NMR and
MS analyses. The physicochemical properties and evaluation of the ADME profile of 3a-i and 4a-i were performed
by the preADMETlab2.0 web program. Cinnamoyl derivatives 3a-i and 4a-i were tested in vitro for their
cytotoxicity against the human healthy fibroblast (HDFa) cells using an MTT cell viability assay. Derivatives
with no toxicity on HDFa cells were tested both on human glioblastoma (U87MG) and neuroblastoma (SHSY-
5Y) cells, chosen as an experimental model of brain tumors. Cell death mechanisms were analyzed by performing
flow cytometry analyses.

Results:

Cinnamoyl derivatives 3a-i and 4a-i showed good physicochemical and ADME properties suggesting
that these compounds could be developed as oral drugs endowed with a high capability to cross the blood-brain
barrier. Compounds (E)-1-methoxy-4-(2-(phenylsulfonyl)vinyl)benzene (2c) and (E)-N-benzyl-N-(2-
(cyclohexylamino)-2-oxoethyl)-3-(3,4,5-trimethoxyphenyl)acrylamide (3e) did not show cytotoxicity on healthy
human fibroblast cells up to 100 μg/mL. The most anticarcinogenic molecule, compound 3e, emerged as the most
potent anticancer candidate in this study. Flow cytometry results showed that compound 3e (25 μg/mL) application
resulted in nearly 86% and 84% cytotoxicity in the U87MG and the SHSY-5Y cell lines, respectively. Compound
2c (25 μg/mL) resulted in 81% and 82% cytotoxicity in the U87MG and the SHSY-5Y cell lines, respectively.

Conclusion:

Cinnamoyl derivative 3e inhibits the proliferation of cultured U87MG and SHSY-5Y cells by inducing
apoptosis. Further detailed research will be conducted to confirm these data in in vivo experimental animal
models.
Exploring the Synergistic Effect of Sildenafil and Green Tea Polyphenols on Breast
Cancer Stem Cell-like Cells and their Parental Cells: A Potential Novel Therapeutic
Approach
Authors: Salari Sharif Marzie , Mohseni Habibeh Sadat , Khanavi Mahnaz , Ghadami Shima , Jafarzadeh Emad , Tavajohi Shohreh , Aliebrahimi Shima , Ostad Seyed  Nasser
Published: November 2023

Background::

Many cancer studies have intensely focused on the role of diet, among other factors
involved in cancer establishment. The positive effect of green tea polyphenols (GTP) on controlling breast cancer
cells has been reported in several studies. Cancer stem cell-like cells (CSC-LCs) possessing self-renewal, metastatic,
and drug-resistant capacities are considered prominent therapeutic targets. In many tumors, inducible nitric
oxide synthase (iNOS) expression levels are high; however, they have a dual effect on breast cancer pathogenesis.

Objective::

This study aimed to investigate the cytotoxicity of the iNOS agonist (Sildenafil) and antagonist (LNAME),
both alone and in combination with GTP, on MDA-MB-231, CD44+/CD24- CSC-LCs, and their parental
cells (MCF-7).

Methods::

The cell viability assay has been studied using the MTT assay. To analyze drug-drug combinations,
CompuSyn and Combenefit software were used. The cytotoxicity mechanism was determined using flow
cytometric analysis.

Results::

L-NAME and GTP showed a synergistic effect on MDA-MB-231 and CSC-LCs. Such an effect was not
observed on MCF-7. Sildenafil and GTP, on the other hand, showed synergistic cytotoxicity in all the cells
mentioned above. Flow cytometric tests resulted in more than 70% apoptosis in MDA-MB-231 and MCF-7. Also,
sub-G1 arrest among MCF-7 cells and a considerable decrease in ROS production by MDA-MB-231 cells
following treatment with Sildenafil and GTP were observed.

Conclusion::

Sildenafil, in combination with flavonoids, may be considered a novel strategy for cancer treatment.
Implementación del algoritmo de modulación y demodulación digital utilizando FSK no coherente
Authors: Limaylla Chamorro Kenny F.
Published: November 2023

En el presente trabajo se desarrolla un sistema de comunicación digital binario, el cual permitirá enviar archivos de audio (formato wav) entre dos computadoras, para lo cual se desarrolló los algoritmos de modulación y demodulación digital, escogiéndose la técnica de modulación FSK (Frequency Shift Keying) coherente, y como desmodulación FSK No Coherente (a fin de abaratarlos costos de implementación), el cual presenta buen rendimiento en los medios de comunicación inalámbricos (alta inmunidad a las atenuaciones en amplitud). El sistema de comunicación a desarrollado se probó intercambiando datos entre dos computadoras, las cuales tienen como medio de comunicación un cable de audio. Los algoritmos se desarrollaron en MATLAB.
Roger Ascham’s Latin–Greek Code-Switching: A Philosophical Phenomenon
Authors: Nicholas Lucy Rachel
Published: November 2023

The Englishman Roger Ascham (c.1515–68) was an expert Latinist and Hellenist, and an inveterate code-switcher. This article will assess Ascham’s careful incorporation of Greek into his writing, be it single words, phrases or quotations. It will consider his extensive Latin correspondence and theological treatises that were inflected with Greek; his Latin and Greek poetry; and also one of his most famous tracts composed in the vernacular. I will explore how his use of Greek heightened a sense of sociability at both micro- and macro-levels through the establishment of a network of ‘belonging’. Ascham’s conspicuous cultivation of royalty and nobles also implicated his Greek code-switches in the business of State governance. Yet many of Ascham’s Greek references were religiously freighted through his frequent engagement with the Greek New Testament; this was especially true of his two theological Latin tracts, each of which broached sensitive doctrinal topics and used Greek as a guarantor of religious veracity. In addition to probing the meanings of discrete parcels of Greek, this article will also broach the significant role Greek might play in terms of linguistic enhancement, both for Latin and also the vernacular. Taking this further, I will additionally suggest that Greek could be instrumental in effecting a broader programme of moral formation. Hence a fundamental premise and arrival-point of this paper is that code-switching was more than just a practice; it was a mentality.
Cedaka, czyli czego uczy nas Talmud o dobroczynności
Authors: Tomczyk Dominik
Published: November 2023

Talmud, po Biblii hebrajskiej, należy do najważniejszych ksiąg w kulturze żydowskiej. Jedną z podstawowych postaw człowieka w Talmudzie jest cedaka, czyli okazywanie miłosierdzia poprzez jałmużnę oraz dobre uczynki. Rabini za pomocą licznych historii ukazywali dobroczynność jako sposób naśladowania Boga. Nakazywali, by nie zamykać swojego serca na potrzeby innych, ponieważ sianie sprawiedliwości jest zbieraniem miłości (por. Oz 10, 12). Żydowska cedaka ma wymiar eschatologiczny, gdyż nagroda za dobroczynność zostanie wypłacona w niebie. Zdaniem rabinów nikt nie jest zwolniony z dobroczynności, nawet ten, kto sam z niej korzysta. Talmud poucza nas, że Bóg nakazuje każdemu działać jako Jego pośrednik w dziele miłosierdzia wobec wszystkich potrzebujących.
Automated Machine Learning: A Comprehensive Survey and Framework for Advancements
Authors: Vinod Pal Sonam , Balasaheb Wagh Shraddha , Pandurang Yadav Mandar , Ravindra Yadgude Samrudhi , Sayyad Dr. S F
Published: November 2023

Abstract: Machine learning has become an indispensable tool in numerous domains, and the selection of an appropriate machine learning algorithm can significantly impact the success of a project. To address the challenge of algorithm selection, we present an Automated Machine Learning (AutoML) platform designed to empower users with the ability to effortlessly compare the performance of two selected machine learning algorithms on their datasets. This platform offers a user-friendly interface, guiding users through the entire process, from uploading their datasets to selecting algorithms and making informed decisions. The platform provides a streamlined workflow that allows users to easily upload datasets of their choice, select two machine learning algorithms from a pre-defined set, and compare their performance based on a variety of evaluation metrics. Users can visualize and analyze the results to gain insights into how different algorithms impact their data. Additionally, the platform offers assistance in identifying the most suitable algorithm for achieving optimal results. With the rapid evolution of machine learning techniques, this AutoML platform addresses the need for a user-friendly, efficient, and accessible tool to assist practitioners and researchers in algorithm selection. By simplifying the comparative analysis of machine learning models, this platform empowers users to make informed decisions that enhance the effectiveness of their data-driven projects.
Analysis of Human Resources Capacity for Cultural Heritage Managers in Bengkulu City
Authors: Darmi Titi , Mujtahid Iqbal Miftakhul , Nusantara Bella Dian
Published: November 2023

Cultural heritage is a regional potential asset that can contribute to economic growth, optimal management of cultural heritage is beneficial for the progress of tourism centers. Bengkulu City is one of the cities that has the potential for cultural heritage, which, if managed optimally can have an impact on the economic growth of Bengkulu City. However, the strategic allocation of human resources has not been done well. This study aims to determine how the capacity of human resources for cultural heritage managers in Bengkulu City is. The research method uses qualitative descriptive, data collection is carried out through in-depth interviews and group discussions. We analyzed six informants consisting of cultural heritage managers in the Bengkulu region assigned by the Jambi Province's Jambi Cultural Heritage Preservation Center (BPCB). Data analysis and interpreting the meaning of factual data are carried out qualitatively, and the results of the study show that the availability of human Resources (HR) both in quality and quantity has not been in accordance with the standards for developing human resources for cultural heritage. In addition, the lack of regional participation in increasing institutional capacity related to cultural heritage management has an impact on the non-optimal management of cultural heritage in the Bengkulu City.
Copper Catalyzed Enantioconvergent Nucleophilic Substitutions
Authors: Huang Chunxi , Wan Zilong Wan , Zhu Aoping , Chen Caiyou
Published: November 2023

As a versatile earth-abundant transition metal, Cu has long been widely
applied in the C-C and C-X bond forming reactions. As for now,
low-valent Cu(I) is known to reduce the redox active electrophiles via
an SET pathway to give the corresponding radical and Cu(II) spe-cies.
The resulting Cu(II) species can interact with the radical via the
out-sphere pathway, affording the coupling product. Alternatively,
Cu(II) can trap the radical through the inner-sphere process to generate
Cu(III) species and then realize challenging bond formations due to the
facile reductive elimination of Cu(III) intermediate. Although copper
catalysis has been widely applied in arylations of various nucleophiles,
copper-catalyzed enantioconvergent nucleophilic substitutions of racemic
alkyl electrophiles have been less explored, likely due to the
difficulties in overcoming the reduction potential of alkyl
electrophiles, elimination side reactions, and enantiomeric control. In
order to overcome the high reduction potential of alkyl electrophiles,
the photo-induced strategy has been developed under mild conditions. An
alternative strategy with new anionic tridentate ligands has also been
reported in this regard. This review summa-rizes recent developments in
copper-catalyzed enantioconvergent nucleophilic substitutions of alkyl
electrophiles by various nucleo-philes to realize C-N, C-C, C-B, C-P and
C-O bond formations and their brief mechanistic studies.
Long-term data reveal widespread phenological change across major U.S. estuaries
Authors: Fournier Robert , Colombano Denise , Latour Robert , Carlson Stephanie , Ruhi Albert
Published: November 2023

Climate change is shifting the timing of organismal life-history events
such as hatching, growth, reproduction, and migration. Although
consequential food-web mismatches can emerge if predators and prey shift
at different rates, research on phenological shifts has traditionally
focused on single trophic levels. Here, we analyzed >2000
long-term, monthly time series of phytoplankton, zooplankton, and fish
abundance or biomass for three major U.S. estuaries (San Francisco,
Chesapeake, and Massachusetts bays). Phenological shifts occurred in
over a quarter (27%) of the combined series and shifting taxa
overwhelmingly advanced phenology. However, many
(~34%-68%) taxa did not track the changing
environment, and trends often diverged between predators and their
potential prey. Notably, in the San Francisco Bay most fishes showed a
delayed timing of peak abundance while many zooplankton peaked earlier,
illustrating the potential for climate-driven trophic mismatch. Our
results suggest that even if signatures of global climate change differ
locally, widespread phenological change has the potential to disrupt
estuarine food webs.
Sink formation during shoot infection of tomato Micro-Tom by Moniliophthora perniciosa , the causal agent of cacao witches' broom disease, limits sugar supply for effective development of lateral roots
Authors: Figueira Antonio , Paschoal Daniele , Ometto Vitor , Mendes João Vitor O. , Cazetta Laura , Carrera Esther , Rossi Monica Lanzoni , Aricetti Juliana , Mieczkowski Piotr , Carvalho Gabriel , Cesarino Igor , Silva Simone , Ribeiro Rafael , Teixeira Paulo , Silva Eder da
Published: November 2023

Moniliophthora perniciosa causes the witches’ broom disease of
cacao, and it can infect the tomato Micro-Tom (MT). Typical symptoms are
stem swelling and shoot outgrowth, whereas reduction in root biomass is
another side effect. We investigated whether the impairment of root
growth derives from a hormonal imbalance or sink competition. Intense
stem swelling coincided with a reduction in root biomass, predominantly
of lateral roots. A few genes involved in hormone metabolism were
activated; however, hormonal levels were not altered. Inoculation of the
auxin highly-responsive entire genotype maintained the impaired
root phenotype. Genes involved in root respiration, carbohydrate, amino
acid and cell wall metabolism were repressed, whereas genes linked to
water/nitrogen/phosphorous starvation were upregulated. Lower levels of
sugars and amino acids suggested carbohydrate deprivation. Less
C accumulated in roots of infected MT, but not in
the symptomless low-cytokinin MT-transgenic line that overexpresses
CYTOKININ OXIDASE-2 ( 35S::AtCKX2). We show evidence that
the impairment of root development potentially derives from a reduction
of photoassimilate supply by the establishment of a strong sink at the
shoot symptomatic infection site, rather than hormonal imbalance. We
speculate that this impact may contribute to the dramatic decrease in
cocoa yields after M. perniciosa invasion.
Characteristics of Precipitation and Mesoscale Convective Systems over the Peruvian Central Andes in Multi 5-Year Convection-Permitting Simulations
Authors: Huang Yongjie , Xue Ming , Hu Xiao-Ming , Martin Elinor R , Novoa Hector Mayol , McPherson Renee A. , Liu Changhai , Ikeda Kyoko , Rasmussen Roy , Prein Andreas Franz , Perez Andres Vitaliano , Morales Isaac Yanqui , Ticona José Luis , Luna Auria Julieta Flores
Published: November 2023

Using the Weather Research and Forecasting (WRF) model with two
planetary boundary layer schemes, ACM2 and MYNN, convection-permitting
model (CPM) regional climate simulations were conducted for a 6-year
period at a 15-km grid spacing covering entire South America and a
nested convection-permitting 3-km grid spacing covering the Peruvian
central Andes region. These two CPM simulations along with a 4-km
simulation covering South America produced by National Center for
Atmospheric Research, three gridded global precipitation datasets, and
rain gauge data in Peru and Brazil, are used to document the
characteristics of precipitation and MCSs in the Peruvian central Andes
region. Results show that all km-scale simulations generally capture the
spatiotemporal patterns of precipitation and MCSs at both seasonal and
diurnal scales, although biases exist in aspects such as precipitation
intensity and MCS frequency, size, propagation speed, and associated
precipitation intensity. The 3-km simulation using MYNN scheme generally
outperforms the other simulations in capturing seasonal and diurnal
precipitation over the mountain, while both it and the 4-km simulation
demonstrate superior performance in the western Amazon Basin, based on
the comparison to the gridded precipitation products and gauge data.
Dynamic factors, primarily low-level jet and terrain-induced uplift, are
the key drivers for precipitation and MCS genesis along the east slope
of the Andes, while thermodynamic factors control the precipitation and
MCS activity in the western Amazon Basin and over elevated mountainous
regions. The study suggests aspects of the model needing improvement and
the choice of better model configurations for future regional climate
projections.
Data Breach Severity and Debt Market Responses
Authors: Evans Corey A. , Beyer Brooke , Mason Terry W. , West Ashley N.
Published: November 2023

Prior literature has become increasingly inconsistent as to the impact of data breaches, in part because researchers have not settled on an appropriate identifier for breach severity. The goal of our study is to develop a breach severity measure and validate the new measure by investigating the relation between breach severity and debt market responses. Using the new measure, we find severe data breaches are positively associated with the cost of debt, the size of new debt facilities, the total number of new debt facilities issued, and the average number of lenders included in the new facilities. We also provide evidence that financially constrained firms are more likely to be adversely affected by a severe data breach. Collectively, the results suggest our new breach severity measure is an effective measure of data breach severity.

Data Availability: Data are available from the public sources cited in the text.

JEL Classifications: G32; M41.
Clinical Performance of Minimally Invasive Monolithic Ultratranslucent Zirconia Veneers: A Case Series up to Five Years of Follow-up
Authors: Silva NR , Araújo GM de , Moura DMD , Araújo LNM de , Gurgel BC de Vasconcelos , Melo RM , Bottino MA , Özcan M , Zhang Y , Souza ROA
Published: November 2023

There is a lack of reports in the literature on the long-term clinical performance of ultratranslucent zirconia, especially considering its use in manufacturing monolithic veneers. The purpose of this case series is to describe the aesthetic treatment steps of three patients with minimally invasive ultratranslucent zirconia veneers and to report the clinical findings up to five years. Three patients (woman: 2, man: 1; mean age: 30 years) unsatisfied with their dental aesthetics sought dental treatment. The treatment plan involved cementing ultratranslucent zirconia veneers. Air-abrasion was performed on the internal surface of zirconia with alumina particles coated by silica (silicatization), followed by silane and adhesive applications for the adhesive cementation. All veneers were adhesively cemented to enamel with resin cement (Variolink Esthetic, Ivoclar). The patients were clinically evaluated annually considering the Ryge modified/ California Dental Association criteria. After a mean follow-up of 4.33 years (4-5 years), a survival rate of 100% was detected for the 28 minimally invasive ultratranslucent zirconia veneers cemented in the 3 patients. There were no absolute failures such as debonding, veneer fracture, or secondary caries. Superficial marginal discoloration was observed in one element (maxillary left lateral incisor) of one patient. Ultratranslucent zirconia is a viable option for manufacturing veneers due to its excellent clinical performance and longevity. However, further long-term clinical studies are essential to consolidate this material as an option for esthetic restorations.
Improving Bond Strength of Translucent Zirconia Through Surface Treatment With SiO2-ZrO2 Coatings
Authors: Du Q , Cui T , Niu G , Qui J , Yang B
Published: November 2023

Background

Translucent monolithic zirconia ceramics have been applied in dental clinics due to their esthetic translucent formulations and mechanical properties. Considering inherent ceramic brittleness, adhesive bonding with resin composite increases the fracture resistance of ceramic restorations. However, zirconia is a chemically stable material that is difficult to adhesively bond with resin.

Objectives

To investigate the influences of SiO2-ZrO2 coatings on adhesive bonding of zirconia and the surface characterization of those coatings.

Methods and Materials

Translucent zirconia discs were classified into groups based on surface treatments: CT (control), SB (sandblasting), C21(SiO2:ZrO2=2:1), C11(SiO2:ZrO2=1:1), and C12 (SiO2:ZrO2=1:2) (n=10). Surface characterization of coatings on zirconia were analyzed by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), surface roughness assessment (Ra), X-ray diffraction (XRD), water contact angle (WCA), translucency parameter (TP), and shear bond strength (SBS). Two-way ANOVA for shear bond strength results and ANOVA for Ra and WCA were performed.

Results

SEM images revealed SiO2 islands on zirconia disks coated with SiO2-ZrO2. Surface roughness of C12, C11, and C21 groups was significantly larger than those of groups SB and CT (p<0.05). XRD results showed that phase transformation of zirconia disks was detected only in the SB group. In addition, SiO2-ZrO2 coatings reduced WCA. The translucency decreased only in group C21. Group C11 showed the highest shear bond strength under both aging conditions.

Conclusion

SiO2-ZrO2 coating is a promising method to enhance the adhesive resin bonding of translucent zirconia without causing phase transformation of translucent zirconia.
Nieinwazyjna prospekcja średniowiecznego grodziska w Sądowlu. Problem integracji rezultatów teledetekcji archeologicznej oraz historycznych źródeł kartograficznych
Authors: Kiarszys Grzegorz , Żuk Lidia , Małkowski Wiesław
Published: November 2023

The main aim of this paper is to present the potential of an integrated archaeological survey. Currently established survey practice combines a range of methods such as aerial archaeology, airborne laser scanning and geophysics, and analysis of historical maps. It is commonly assumed that the application of more methods will help to obtain more information about the registered archaeological site. However, a cumulation of collected data does not equate with a better understanding of the analyzed structures. Archaeologists often face fragmentary or even contradictory evidence provided by those methods. Integration of data requires a more flexible approach, a thorough questioning of collected data, meaningful comparison of different results, their re-interpretation and the formulation of new questions according to the mechanism of the hermeneutic circle. We illustrate these issues using the case study of an integrated survey at a medieval stronghold in Sądowel. In particular, we focused on various degrees of success with which different non-invasive methods were applied and changing interpretations of recorded structures.
Od Redakcji
Authors: Markiewicz Małgorzata
Published: November 2023

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Talent og talentutvikling – et gammelt felt i nye klær?
Authors: Stabell Ellen M.
Published: November 2023

Historically, the music conservatoires provided education of musicians under the same roof as music tuition for children and amateurs. This was an organic way of organizing an education where an early start is beneficial and entrance to the profession requires years of lengthy practice. When the Norwegian Academy of Music was founded in 1973, pre-college music education was separated from higher education for many years, as was the case for most conservatoires. Finally, in 2004 the talent development programme Young Musicians started up, a programme that was run by institutions for higher music education. Since then, a talent development field has evolved in Norway. In this article, I do a discourse analysis (Laclau & Mouffe, 2001) of central reports and recommendations, the oldest from 1986 and the newest from 2020, where leaders and staff of higher music education institutions have been involved in improving the quantity and quality of talent development in Norway. The study identifies three discourses competing to articulate talent development, being a social democratic discourse of adapted education, access, and breadth, a professionalisation discourse defined by competitive ability, a prescription of development, and a set goal, and a Bildung discourse defined by holistic education, open goals, and focusing on the pupil’s needs. Talent is articulated by three discourses, namely an inborn discourse, an effort discourse, and a motivation discourse.
En utdanning i musikkterapi – en sentral del av Norges musikkhøgskoles samfunnsansvar
Authors: Ruud Even , Trondalen Gro
Published: November 2023

The article outlines vital features in the development of music therapy studies and research in music therapy at the Conservatory of Eastern Norway and the Norwegian Academy of Music from the seventies until today. The article is an original contribution describing the academisation of music therapy, as it occurred in the year of its inception and developed with the study’s anchoring at the Norwegian Academy of Music. The article points to social and political currents in the post-war period that led to changes in the attitudes toward people with disabilities. A central issue in the paper concerns how the music therapy profession represented changes in the concept of music itself, in addition to conceptions of music’s functions and the values and ethical challenges associated with the musical practice. The music therapy program introduced a new type of admission requirement based on improvisation skills, ability to musical communication and personal suitability based on interest in and practical experience in working with people with disabilities.
«Det skjer jo ingenting der oppe, jo!»: Noen subjektive betraktninger over komposisjonslinjens første 50 år ved NMH og noen refleksjoner over komposisjonsundervisningens langsomhet – eller var det hurtighet?
Authors: Schaathun Asbjørn
Published: November 2023

Since the founding of the Norwegian Academy of Music (NMH) in 1973, Norwegian musical life has expanded and undergone significant and profound changes. This essay discusses NMH’s composition department’s contribution to these fundamental changes. Indeed, what has NMH managed to bring into Norwegian music life in the area of compositional music? The conflict between modernism and traditionalism, or nationalism and internationalism, is a contradiction which, despite changing expressions throughout the 20th century, has been a fundamental and highly present dichotomy in Norwegian musical life, the educational environment and teaching right up to our time. Can we find traces of this fundamental dichotomy in the design of the school’s composition teaching? The essay presents some subjective reflections on these key questions. The author was part of the first group of students at NMH’s bachelor’s programme in composition, established in 1981, and has been a teacher at the Academy for the last thirty years. In the essay’s conclusion, he attempts, starting from a literary pair of opposites, speed and slowness (taken from the Czech-French writer Milan Kundera) to share some thoughts on whether it is possible to teach composition at all, all the while there is no generally recognised methodological work or fixed didactic scheme for teaching the subject ‘free’ composition systematically.
Hotet från Ryssland
Authors: Eggen Karen-Anna
Published: November 2023

Oscar Jonsson har skrevet en viktig og lettlest bok (Hotet från Ryssland) som grundig utforsker Russlands syn på verden og hvordan vi kan forstå trusselen fra Russland. Han belyser på forbilledlig vis bredden i – og samspillet mellom – de militære og ikke-militære virkemidlene Russland bruker for å fremme sine interesser. Bokens relevans strekker seg utover det svenske publikumet den er skrevet for og vil være av interesse for alle som ønsker å forstå både Russland og det nye sikkerhetspolitiske landskapet Europa befinner seg i.
Oscar Jonsson has written an important and accessible book (Hotet från Ryssland, in English: The Threat Posed by Russia) that thoroughly explores Russia's perspective on the world and how we can understand the threats posed by Russia. Jonsson describes the vast array of military and non-military means available to Russia and how they are used in combination to enhance Russia’s interests. The book's relevance extends beyond the Swedish audience it was written for, and it will be of interest to anyone seeking to understand both Russia and the new security-political landscape Europe finds itself in.