bluuebunny/crossref_metadata_2025 huggingface dataset:
Students’ Values of Various Training Profiles in the Digitalization of Society Context: Results of an Empirical Study
Authors: Deryugin P. P. , Bannova O. S.
Published: November 2022

Introduction. The upcoming digitalization has a peculiar effect on the purposefulness of students' behavior, ensuring the transition to a new stage in the development of a postindustrial society. Social norms, values, and value orientations are subject to change. All this is formed into a new group of student digital values, which are shaped differently among students of various professional training profiles. These new phenomena involve the search for new methodological and methodological approaches to conducting empirical sociological research, the search for relevant approaches to measuring the digital values of students of various training profiles, and identifying special characteristics and meaningful features of these values.

Methodology and sources. The research methodology is mixed, and is based on provisions about values and their specific forms of manifestation, particularly digital values (M. Weber,  F. Znanetsky, T. Parsons, E. Durkheim, A. Toffler). The digital society is a new perspective, the nature of which is inconsistently consistent with some of the principles of the traditional approach to the study of values that have developed in theoretical concepts earlier. The concepts of modern authors were used, such as M. Tomasello, F. Warneken, R. Hogan,  B.W. Roberts, E.F. Zeer, R. Kadakal, and Nguyen Hoang Huu. 

Results and discussion.The methodological approaches to the study of the values of the digital society as an object of study are generalized, in particular, the relevance of the system approach. The differences between the study of traditional values and the values of the digital society are shown, as a result of the analysis of which the accumulation of human capital by students with special (digital) characteristics could be considered as a main value of the digital society. Under these conditions, students of the humanitarian direction (journalists, sociologists) more often define for themselves value-goals as the most important values, and programming students define value-means as such. 

Conclusion. The study used a systematic approach to building a methodology for diagnosing digital values, which allows identifying the main value preferences of students of various training profiles. It is concluded that students of different training profiles understand the digital society differently, which implies different methodological approaches to the study and diagnosis of these values.
Post-Disaster Mental Distress Relief: Health Promotion and Knowledge Exchange in Partnership with a Refugee Diaspora Community
Authors: Simich Laura , Andermann Lisa , Rummens J Anneke , Lo Ted
Published: November 2022

After the 2004 Asian tsunami, a group of concerned scientists, physicians, and community service providers united to form a Local Distress Relief Network (LDRN) to provide information, referral, and care to affected members of the large Sri Lankan Tamil community in Toronto. The LDRN organized a workshop that brought together community-based organizations and international and local experts in mental health and disaster response to review existing knowledge on disaster response and to share community knowledge and experience. This article summarizes the development of the network, the workshop proceedings and joint recommendations for communitybased, culturally appropriate mental distress relief.
Analyzing the Relationship between Creativity and Translation Quality: A Case Study of Students’ Translations
Authors: Manipuspika Yana Shanti
Published: November 2022

Creativity is an area that has received limited attention in Translation Studies (TS). One reason for this could be that creativity is a complex concept to define and quantify, but it is also the case that translators are not usually regarded as creators. The present research tries to shed light on how creativity affects translation quality. Moreover, the participants are translation students, which is also rare in studies about this particular topic. The instrument used in this study was the Kaufman Domain of Creativity Scale (K-DOCS) to assess the students’ creativity. Another instrument was Waddington’s model for translation quality assessment. SPSS software version 24 was used to analyze the collected data. Then, the Pearson Correlation Test was employed to find the possible relationship between the variables. The results displayed that among 40 participants involved in this study, their level of creativity was in the range of ‘high’ as much as 60%, ‘very high’ 25%, and ‘medium’ and ‘low’ with 12.5% and 2.5%, respectively. In terms of translation scores, the mean score was 7.18, with the highest score of 8.55 and the lowest at 5.45. As revealed by the Pearson Correlation test, concerning the degree of relationship between variables, there was no significant relationship between creativity and quality. It indicates that more creative participants did not necessarily perform better in the work of translating. A recommendation is made for future researchers to involve more variables as well as a greater number of participants to enrich the research results and increase the likelihood of creating generalizations regarding the correlation between creativity and translation results.
Efectos de cursos remediales de lectura y matemáticas en logro y desigualdades educativos durante la Covid-19 en México
Authors: Hevia de la Jara Felipe José , Vergara-Lope Tristán Samana
Published: November 2022

El cierre de escuelas producto de la pandemia de Covid-19 representa la emergencia educativa más importante del siglo XXI. Las recomendaciones internacionales incluyen la realización de cursos remediales para enfrentar esta emergencia educativa. El objetivo es analizar la efectividad de cursos remediales que utilizan la metodología de “Enseñar en el nivel adecuado” (Teaching at the Right Level -TaRL) en 1) aprendizajes básicos de lectura y matemáticas, y 2) en la atención a las desigualdades educativas que la pandemia de Covid ha provocado en el sistema educativo mexicano. Metodología: participaron un total de 360 sujetos con promedio de 9.49 años, de una muestra intencional en Veracruz, México. Se aplicaron intervenciones presenciales y a distancia, y se realizaron mediciones pre-post para evaluar la intervención. Resultados: se identificaron ganancias positivas y significativas en los aprendizajes de los participantes que recibieron los cursos: 0.54 DE en lectura y 0.34 DE en matemáticas. Los cursos remediales TaRL permitieron reducir levemente brechas de género, nivel socioeconómico, localidad y discapacidad. Se discute la necesidad de implementar cursos basados en evidencia para fortalecer los aprendizajes básicos que permitan acelerar los aprendizajes y disminuir las desigualdades educativas, que con la pandemia se incrementaron de manera importante.
PENGARUH PIUTANG USAHA DAN UTANG USAHA TERHADAP ARUS KAS OPERASI MASA DEPAN PADA PERUSAHAAN SUB SEKTOR TRANSPORTASI YANG TERDAFTAR DI BURSA EFEK INDONESIA (BEI) TAHUN 2019-2021
Authors: Apriliani Ria , Martaseli Evi , Sudarma Ade
Published: November 2022

Tujuan dari penelitian ini yaitu untuk menjelaskan pengaruh piutang usaha terhadap arus kas operasi masa depan, pengaruh utang usaha terhadap arus kas operasi masa depan, serta pengaruh piutang usaha dan utang usaha terhadap arus kas operasi masa depan. Subjek dalam penelitian ini yaitu perusahaan sub sektor transportasi yang terdaftar di Bursa Efek Indonesia (BEI) periode 2019-2021. Jumlah sampel yang digunakan dalam penelitian ini sebanyak 12 perusahaan dengan teknik random sampling. Metode penelitian yang digunakan peneliti dalam penelitian ini adalah metode asosiatif dengan pendekatan kuantitatif. Serta menggunakan uji asumsi klasik, analisis regresi linear berganda, dan uji hipotesis dengan SPSS 25.Hasil yang didapatkan dari penelitian ini yakni secara parsial piutang usaha memiliki dampak positif yang signifikan terhadap arus kas operasi di masa depan dengan nilai signifikansi 0,000, utang usaha memiliki dampak positif yang signifikan terhadap arus kas operasi di masa depan dengan nilai signifikansi 0,013, serta secara simultan piutang usaha dan utang usaha berpengaruh terhadap arus kas operasi masa depan dengan nilai signifikansi 0,000. Kata Kunci: Piutang Usaha, Utang Usaha, Arus Kas Operasi Masa Depan.
A Community and Hospital cAre Bundle to improve the medical treatment of severe cLaudIcation and critical limb iSchaemia (CHABLIS)
Authors: Watson Emma , Bridgwood Bernadeta , Saha Prakash , Bown Matthew , Benson Ruth , Lawrence Vanessa , Le Boutillier Clair , Lasserson Daniel , Messeder Sarah , Saratzis Athanasios
Published: November 2022

Background: Patients with peripheral artery disease (PAD) often do not receive optimal best medical therapy (BMT). Through interaction with patients and haealthcare-professionals (HCPs) we developed the LEaflet Gp letter Structured checklist (LEGS) complex clinical intervention to support HCPs provide guideline-compliant PAD BMT.

Methods: This was a prospective multicentre study assessing the feasibility and fidelity of delivering the LEGS intervention in primary and secondary care over 6 months. Intervention fidelity was scored based on the proportion of intervention components used correctly at discharge, 30 days, and 6 months.

Results: Overall, 129 individuals were screened and 120 took part (33% female, 74% with chronic limb threatening ischaemia; 93% recruitment rate). Of those, 118 (98% retention rate) completed follow-up. Mean intervention fidelity score at discharge (primary outcome measure) was 63% [95% Confidence Interval (CI): 39-68%, SD: 5%], exceeding the success criteria set at 60% by a panel of HCPs and patients. This, however, declined to 51% at 6 months. Eight patients (6.7%) died (all cardiovascular deaths), 4 (3.3%) had a major lower limb amputation, 12 (10%) had a cardiovascular event, and 13 (11%) were admitted due to limb ischaemia at 6 months. Incomplete lipid therapy prescriptions and LEGS intervention documents not received by primary care CHPs were the most common reasons for not complying with the LEGS intervention.

Conclusion: The LEGS intervention can be delivered in PAD care pathways across different hospitals, primary, and community healthcare settings with acceptable fidelity, to streamline and improve PAD BMT short and medium term.
Identifying Multisystem Inflammatory Syndrome in Children After COVID-19 Infection
Authors: McKeiver Anthony , Desai Gautam , Cox Joshua
Published: November 2022

Introduction: Since its discovery, the novel coronavirus disease 2019 (COVID-19) has evolved into a global pandemic that has affected millions. The pediatric population was once thought to be mostly spared from the SARS-CoV-2 virus. However, a severe hyperinflammatory sequela of the virus known as multisystem inflammatory syndrome in children (MIS-C) has since been identified and poses a great risk to pediatric morbidity and mortality. The goal of this manuscript is to clarify and characterize MIS-C as a diagnosis, including current management and future considerations. Methods: A thorough literature search was performed using Google Scholar and PubMed databases for articles published January 2020 through August 2021. Results: A two-tiered diagnostic approach was created for any pediatric patient presenting with fever and an epidemiologic link to SARS-CoV-2. The mean age at time of diagnosis was 9.3 years old, with 56.8% of patients identifying as male and the majority identifying as either Hispanic (36.5%) or Black (35.1%). Common signs and symptoms included fever, cough, tachycardia and tachypnea. Current treatment recommendations included IVIG, glucocorticoids, and aspirin, with the more severe cases needing hospitalization and immune modulator therapy. Discussion: MIS-C is a serious and potentially fatal sequelae after COVID-19 infection in the pediatric population. Much is still unknown regarding the long-term effects of MIS-C. Further emphasis should be placed on identifying definitive treatment and preventative strategies. Osteopathic family physicians are the primary providers for many of the patients who may present with signs and symptoms of MIS-C, and familiarity with the workup and treatment can help improve care.
Leveraging Primary Care, Public Health and Social Context During the COVID-19 Response Within a University Setting: Considerations for the Osteopathic Family Physician
Authors: Jones Anne , Mukherjee Kanad , Schachter Todd
Published: November 2022

The COVID-19 pandemic placed a spotlight on both the successes and the needs across the spectrum of the healthcare system. The trusting, enduring relationships developed within the primary care setting served as an important foundation on which to build response strategies throughout the pandemic. Early detection and testing, implementation of telehealth, delivery of continuous comprehensive care, and vaccine education and administration are all key areas where primary care and public health systems successfully served patients and community. Emerging national research from the COVID-19 pandemic experience has also demonstrated the reduction in COVID-19 infection and death rates through the synergy between primary care, public health and social factors, emphasizing once again the critical role these services play and the importance of developing integration strategies for the future. In particular, the COVID-19 experience within the university setting served as a key example of this integration and synergy in action. As osteopathic family physicians, these experiences can serve as lessons learned toward embracing the opportunity afforded by our unique training, expertise and commitment to the osteopathic philosophy.
Peningkatan Self Management Melalui Program Telemonitoring Terhadap Kepatuhan Medikasi Pasien Congestive Heart Failure (CHF): A Literatur Review
Authors: Selvia B Heni , Sjattar Elly L , Madjid Abdul
Published: November 2022

Congestive Heart Failure (CHF) is a chronic complex syndrome characterized by the inability of the heart to support Congestive Heart failure is a clinical syndrome characterized by shortness of breath, swelling of the ankles, and fatigue. One of the actions taken for the treatment is to improve self-management and patient medication adherence through a telemonitoring program. The study review's purpose was to identify the effect of a telemonitoring program in improving the self-management of congestive heart failure patients on medication adherence. The literature review used some electronic databases including Pubmed, Google Scholar, and ScienceDirect, and obtained seven articles that meet the inclusion criteria. The results showed that the telemonitoring program was effective in increasing medication adherence, blood pressure control adherence, improving medication regimens, reducing treatment costs, and improving self-management of patients with congestive heart failure. The telemonitoring program becomes an appropriate solution to enhance patient self-management on medication adherence as prevention and management of this disease. Telemonitoring programs were also known to reduce readmission of congestive heart failure patients to hospitals or clinics, reduce treatment costs, increase adherence to treatment regimens, and patient self-care management.
Efektivitas Deep Tissue Self Massage Therapy Dan Slow Deep Breathing Terhadap Penurunan Tekanan Darah Pada Klien Dikeluarga Pedagang Pasar Tradisional
Authors: Abidin M. Zainal , Prasetyo Agus , Taryatmo Taryatmo , Warijan Warijan , Ulliya Sarah
Published: November 2022

The prevalence of hypertension in traditional market traders is increasing, due to stress, work pressure, physical, and mental fatigue, and the burden of life. Hypertension can be prevented and controlled with non-pharmacological therapy by regulating lifestyle and relaxation. The purpose of this study was to identify the effectiveness of Deep Tissue Self Massage Therapy and Slow Deep Breathing in reducing blood pressure in hypertensive clients in families who work as traditional market traders. Quasi-experimental research design with two groups pretest-posttest used. Paired sample t-test was used in both groups before and after the intervention. Samples were collected using a proportional stratified random sampling technique with 100 respondents divided into 50 participants in each group. The results showed there was a decrease in systolic and diastolic blood pressure after the intervention of Deep Tissue Self Massage Therapy (tb = 7,997; pb = 0,004); (ta = 6.018; pa = 0.000), and there was a decrease in systolic and diastolic blood pressure after the Slow Deep Breathing intervention (tb = 7.311; pb = 0.000); (ta = 6.032; pa = 0.000). In conclusion, Deep Tissue Self Massage Therapy and Slow Deep Breathing have been shown to reduce both systolic and diastolic blood pressure in hypertensive clients. Further study using the control group as a comparison is recommended
Konsumsi Susu Kedelai Dengan Air Rebusan Kelor Terhadap Penurunan Dismenore Primer Pada Remaja Putri
Authors: Susmini Susmini , Rosdiana Yanti
Published: November 2022

A common health problem in adolescent girls is dysmenorrhea. Dysmenorrhea or also known as menstrual pain is one of the complaints that can be experienced by women during menstruation. The study's purpose was to determine the difference between the consumption of soy milk and boiled water of Moringa on primary dysmenorrhea in adolescents. The type of research used is quantitative research using a quasi experiment design with pre and post-tests without control. The purposive sampling method used recruited 19 participant who experienced primary dysmenorrhea on TlogoSurya Rt 02/Rw 02 street, Tlogomas, Malang city. The HARS instrument used for assess the pain scale. Data were analyzed using the independent t-test and paired t-test. Results showed a significant difference in the decrease of primary dysmenorrhea pain level after giving a combination of soy milk and Moringa boiled water in adolescent girls (p-value = 0.003), where there was a decreasing in primary dysmenorrhoea pain scale in the Moringa boiled water group. The study concluded that there was a significant difference in the decrease of the pain scale of primary dysmenorrhea after giving soy milk and Moringa boiled water. It also found that the decrease of the pain scale of primary dysmenorrhea was high in the group given Moringa boiled water.
Determinan Kegagalan Pemberian Asi Eksklusif Pada Ibu Menyusui Di Wilayah Puskesmas Banda Raya Kota Banda Aceh
Authors: Oktaviyana Cut , Pratama Urip , Igbal Muhammad , Fitriya Ika Rahmi , Adha Mutiara Nurul , Nelly Zia Novia
Published: November 2022

Capaian pemberian ASI eksklusif di kota Banda Aceh berada di bawah capaian nasional 80%, yaitu 59% tahun 2020 sehingga jauh dari capaian program Sustainable Development Goals (SDGs). ASI eksklusif tidak dijalankan menyebabkan berbagai masalah kesehatan bayi terutama pada pertumbuhan, perkembangan bayi, imunologis, psikologis serta ekonomi orang tua bayi. Cakupan pemberian ASI terendah berada di wilayah Puskesmas Banda Raya (34,2%). Rendahnya capaian menunjukkan program ASI eksklusif belum maksimal. Beberapa faktor seperti pengetahuan, dukungan sosial, Breastfeeding Self-Efficacy (BSE) serta sosial budaya adalah hal yang dikaitkan dengan ASI eksklusif. Penelitian bertujuan mengetahui hubungan determinan kegagalan pemberian ASI eksklusif di wilayah kerja Puskesmas Banda Raya Kota Banda Aceh. Penelitian cross sectional dengan 67 sample ibu menyusui usia bayi 6 – 11 bulan dengan kondisi tanpa riwayat penyakit kongenital dan kronis serta menggunakan purposive sampling. Data dikumpulkan melalui pembagian kuesioner tanggal 8 – 12 Agustus 2022 di  wilayah kerja Puskesmas Banda Raya. Hasil analisis uji regresi logistik sederhana bahwa ibu memiliki pengetahuan baik berpeluang 43% (OR 0,43) menjalankan ASI eksklsuif. Ibu memiliki BSE tinggi berpeluang 5,11 kali (OR 5,11) tetap memberikan ASI eksklusif. Ibu dengan sosial budaya yang mendukung berpeluang 18% (OR 0,18) memberikan ASI eksklusif. Variabel tersebut menjadi penentu kegagalan ibu untuk memberikan ASI eksklusif. Promosi kesehatan ASI eksklusif perlu ditingkatkan kepada orang tua bayi, keluarga serta tenaga kesehatan terkait.
Pemberdayaan Ibu Siaga Terhadap Tingkat Kemandirian Pencegahan Dan Keterampilan Perawatan Balita Pneumonia
Authors: Rosuliana Novi Enis , Nurhayati Tetik
Published: November 2022

Pneumonia is an acute infectious disease of the lower respiratory tract (alveoli). Pneumonia cases in Indonesia in 2018 reached 20.06%, while West Java was 4.62% above the national case estimate. The risk factors for pneumonia are exclusive breastfeeding, malnutrition, immunization status, history of LBW, smoking, economy, and home environment. The purpose of the study was to determine the effect of empowering alert mothers on the independence of prevention and care skills of pneumonia under five. The research design is a quasi-experimental pre-test and post-test with a control group design. The population is all mothers who have toddlers in the sub-village of Ciamis Regency with a total of 100. The research sample consisted of 60 respondents divided into the intervention group and the control group with consecutive sampling. The research instrument is in the form of a pneumonia prevention independence questionnaire and pneumonia care skills for toddlers. Data were analyzed using Wilcoxon Signed Ranks and Mann-Whitney U Test. The results showed a p-value of 0.000 p-value of 0.05, indicating the effect of empowering alert mothers on the independence level of prevention and care skills of pneumonia under five. Further research relates the application of complementary therapy to the treatment of pneumonia under five is needed.
Terapi Komplementer Menggunakan Aromaterapi Minyak Esensial Berpengaruh Terhadap Insomnia Pada Ibu Menopause di ATMA Home Care Poncokusumo
Authors: Rufaindah Ervin , Patemah Patemah
Published: November 2022

Women will experience menopause physiologically at the age of 45 and show different signs symptoms. Menopause can cause psychological disturbances like frequent drowsiness, difficulty concentrating, insomnia, and fatigue. This study aimed to determine the effect of essential oil aromatherapy on insomnia. The pre-experimental design was used, with the One Group Pretest-Posttest approach to 30 menopausal women with insomnia in the ATMA Home Care Poncokusumo area, Malang Regency. The sampling technique chosen was accidental sampling. The data on insomnia was examined by modifying the KSPBJ-IRS-10 questions. The differences between groups were analyzed using the Wilcoxon Signed Rank Test. The respondents' age ranged between 46-53 years old (average 48 years), the average length of menopause was two years, and most graduated from high school, with mild insomnia. After the treatment, the respondents experienced a decrease in insomnia with a smaller mean score (19.5 to 11.5), p-value = 0.000 0.05, which means that there was a significant difference between the score of insomnia. It can be concluded that aromatherapy of essential oils can reduce the degree of insomnia in menopausal women. It is recommended to properly monitor the evaluation of the use of aromatherapy online and through home visits, as well as measure the characteristics of respondents.
Usia, Riwayat Pendidikan, Activity Daily Living (ADL) Berhubungan Dengan Kejadian Demensia Pada Lansia
Authors: Leton Elisabet Masan , Putri Ronasari Mahaji , Devi Hilda Mazarina
Published: November 2022

Fungsi kognitif menurun seiring dengan meningkatnya usia. Lansia dengan ADL dan pendidikan rendah juga beresiko terhadap terjadinya demensia. Tujuan penelitian ini adalah mengidentifikasi usia, riwayat pendidikan dan ADL terhadap kejadian demensia pada lansia. Desain penelitian yang digunakan adalah cross-sectional korelasional. Populasi penelitian adalah seluruh lansia di Pondok Lansia Al-Ishlah Kecamatan Belimbing, Kota Malang sebanyak 35 orang. Jumlah sampel sebanyak 32 orang dipilih menggunakan teknik simple random sampling. Instrumen berupa kuesioner ADL menggunakan Indeks Barthel Collin dan kejadian demensia menggunakan MMSE. Data kemudian diuji menggunakan fisher’s exact. Hasil menunjukan bahwa 50% responden berusia 75-90 tahun, sebagian besar (75%) responden memiliki riwayat pendidikan dasar, hampir setengah responden (40,6%) memiliki ADL kategori ketergantungan berat, dan hampir setengah responden (37,5%) memiliki gangguan fungsi kognitif sedang. Hasil Analisa menunjukkan terdapat hubungan antara usia (0,004), riwayat pendidikan (p value 0,044) dan ADL (p value 0,034) terhadap kejadian demensia. Peneliti selanjutnya diharapkan dapat menggali lebih lanjut faktor lain seperti asupan zat gizi yang berkaitan dengan kejadian demensia pada lansia.
Tingkat Kecemasan Pasien Dan Keluarga Yang Rawat Inap Di RSPW Malang Selama Pandemi Covid-19
Authors: Ardiyani Vita Maryah , Sutriningsih Ani
Published: November 2022

Increased anxiety is a common mental health problem during Covid-19. Anxiety can cause symptoms of insomnia, poor concentration, irritability, reduced productivity, interpersonal conflict, stigma, and fear of transmission to vulnerable groups. The purpose of this study was to identify the anxiety level of patients and families who were treated at Panti Waluya Sawahan Malang Hospital during the pandemic.Covid-19. This type of research is descriptive with a cross-sectional approach. The study population was all patients and their families who were treated at RSPW Malang during Covid-19, with a total sampling technique of 20 people. The research variable is the level of anxiety. The instrument used was a questionnaire containing the general identity of the respondent, including the respondent's name, age, gender, and education. The anxiety level instrument uses the HRS-A (Hamilton Rating Scale for Anxiety) which consists of 14 question items. Data were analyzed descriptively and presented in a frequency table. The results of the study found that 70% of respondents had a moderate level of anxiety. Further research is suggested to study other factors related to anxiety in patients and families in the hospital.
ADAPTASI SOSIAL DALAM MASYARAKAT MULTIKULTURAL ERA KETERBUKAAN INFORMASI
Authors: Ramadani Helsi , Indraddin Indraddin , Azwar Azwar
Published: November 2022

Transmigration is one of the government programs in the context of solving population problems which was reopened in 2016 in Sijunjung Regency, namely Kenagarian Padang Tarok. Consisting of ethnic Javanese and ethnic Minangkabau. Given the two different ethnic backgrounds, it is necessary to make an adaptation. The purpose of this study was to determine social adaptation in a multicultural society in the era of information disclosure. This study uses the theory of Arnold Toynbee Challenge and Response. Qualitative method. Data collection with observation and in-depth interview techniques. Informants were taken using purposive sampling technique. Based on the results of the study, it was concluded that the challenges of the Padang Tarok transmigrant community were in the form of language differences, a feeling of being ignored which gave rise to negative sentiments, the emergence of camps and groups between blocks, job choices. and the response to these challenges is to apply Indonesian as a means of communication, to apply an attitude of mutual openness and sharing, to participate in community activities, and to gain gold as a new form of work. The people of Padang Tarok live in a high sense of respect and have an attitude of helping each other.AbstrakTransmigrasi merupakan salah satu  program pemerintah dalam rangka pemecahan masalah kependudukan yang dibuka kembali pada tahun 2016 di Kabupaten Sijunjung yaitu Kenagarian Padang Tarok. Terdiri dari Etnis Jawa dan Etnis Minangkabau. Mengingat kedua latar belakang etnis berbeda maka perlu dilakukan sebuah adaptasi. Tujuan penelitian ini adalah Mengetahui adaptasi sosial dalam masyarakat multikultural era keterbukaan informasi. Penelitian ini menggunakan teori Arnold Toynbee Challenge and Respons. Metode kualitatif. Pengumpulan data dengan teknik observasi dan wawancara mendalam. Pengambilan informan menggunakan teknik Purposive sampling. Berdasarkan hasil penelitian disimpulkan bahwa tantangan masyarakat transmigran Padang Tarok berupa Perbedaan bahasa, timbul rasa tidak dipedulikan yang memunculkan sentimen negatif, munculnya kubu-kubu dan kelompok antar blok, pilihan pekerjaan. serta respon dari tantangan tersebut adalah menerapkan Bahasa Indonesia sebagai alat komunikasi, menerapkan sikap saling terbuka dan saling berbagi, berpatisipasi dalam kegiatan masyarakat, dan mendulang emas sebgai bentuk pekerjaan baru. Masyarakat Padang Tarok hidup dalam menerapkan rasa harga-menghargai yang tinggi dan memiliki sikap saling tolong-menolong antar sesama.
Analysis of the Among System-Based Discovery and Inquiry Learning Models
Authors: Hermita Neni , Putra Zetra Hainul , Alim Jesi Alexander , Fitriani Mike , Nasien Dewi , Mahbubah Khoiro
Published: November 2022

This study compares the syntax of the discovery learning and inquiry learning models based on the Among system. This research was a descriptive type of research and used a comparative design. The method of data collection in this research was a literature study. The literature study used is research that is in accordance with the research of researchers and the latest research. The results found that the learning model of discovery learning and inquiry learning based from the Among system was very well implemented in elementary schools. The use of these various models can be adapted to the needs of the educator. Along with the literature study, these two models can support students' abilities and create meaningful learning for students.
The Effects of Gender, Study Major, and Year of Study on Prospective Teachers’ Mathematical, Didactic, and Technological Knowledge
Authors: Putra Zetra Hainul , Hermita Neni , Yuliani Suci , Fatmawilda Fatmawilda
Published: November 2022

Teachers’ mathematical, didactic, and technological knowledge has been a central issue for the last few decades. Therefore, this study investigates and compares prospective teachers’ mathematical, didactic, and technological knowledge referring to gender, year of study, and academic major. This study used an online survey through online questionnaires. The population was prospective elementary and mathematics teachers from a public university in Riau province, Indonesia. The questionnaires were distributed via WhatsApp, and LMS integrated in courses in the University. There were 195 prospective teachers participated in this study. A non-parametric statistical analysis was used to compare teachers’ knowledge based on gender, year of study, and academic major. The findings reveal that there were no significant differences of teachers’ mathematical, didactic, and technological knowledge based on gender, year of study, and academic major. Therefore, mathematics learning at university has no impact on prospective teachers’ self-evaluation of their knowledge.
Non-Malignant Portal Vein Thrombosis in Liver Cirrhosis: Diagnosis and Treatment
Authors: Artaza Tomás , Lopes Miriam , Romero Marta , Sánchez Juan José , De la Cruz Gema , González Concepción , Gómez Rafael
Published: November 2022

Portal vein thrombosis (PVT) is considered a common complication of liver cirrhosis. Its prevalence increases with liver disease severity, reaching 25% in patients awaiting liver transplantation (LT). The majority of patients with cirrhosis are diagnosed incidentally with PVT during routine ultrasound in their cirrhosis follow-up. Doppler ultrasound is the recommended first-line investigation. Computed tomography or magnetic resonance angiography are the best methods to assess the extent of the PVT. The natural history of PVT in liver cirrhosis is not very well defined, but in the context of LT the deleterious effects of PVT are better known. There are no consensus guidelines about the treatment of PVT in cirrhotic patients and although anticoagulation is considered as the first-line therapy, the evidence regarding this treatment is based on a small series of patients. Nonetheless, it seems that anticoagulation therapy is useful in cirrhotic patients with PVT, particularly in patients who are candidates for a LT, in order to maximise the recanalisation rate and prevent thrombus progression. This treatment must be administered as soon as possible following a prophylactic treatment to avoid variceal bleeding, otherwise it seems to have a broad safety profile. A transjugular intrahepatic portosystemic shunt would be the alternative procedure for patients with no response to anticoagulation therapy or where portal hypertension complications occur.
Proactive Risk Management: A Novel Approach to Embedding Oral Corticosteroid Stewardship into Asthma Care
Authors: Price David , Bourdin Arnaud
Published: November 2022

The continued inclusion of oral corticosteroids (OCS) in treatment guidelines, as well as the accessibility, familiarity, and relatively low cost of this therapeutic option compared with newer alternatives, has contributed to an ongoing overreliance on OCS treatments in severe asthma. This overuse continues despite accumulating evidence to demonstrate the detrimental long-term effects associated with even a short-term, low-dose course of OCS in this patient population.

OCS Stewardship is a collaborative, systematic effort designed to protect patients with asthma from inappropriate OCS use through a series of patient- and physician-focused initiatives. Ultimately, OCS Stewardship aims to reduce OCS-related morbidity, lower the risk of OCS-related adverse events (AE), increase health-related quality of life, and reduce healthcare resource utilisation.

This article summarises data that were exhibited as part of the European Respiratory Society (ERS) International Congress held in Barcelona, Spain, describing a novel proactive risk-management approach to embedding OCS Stewardship into asthma care. The objectives of this meeting were to highlight the latest data demonstrating the need for OCS Stewardship in asthma; discuss approaches to assessing OCS exposure and OCS-related toxicities, and the rationale for systematic assessment of OCS toxicity in individual patients; and to consider practical tools to evaluate future risk of asthma exacerbations and OCS-related adverse effects. Also described in this article are three posters, which were presented during the same meeting, and provide further data to support OCS-sparing activities in severe asthma by AstraZeneca.
Introduction: Decolonising Gothic
Authors: Duncan Rebecca
Published: November 2022

This introduction to the special issue – ‘Decolonising Gothic’ – provides an overview of major existing approaches to gothic in the international context – namely postcolonial- and globalgothic – and highlights developments in contemporary Gothic production that demand a critical shift beyond these frameworks. The article outlines decolonial thinking as one productive response to this situation, and reflects both on what it might mean to ‘decolonise’ Gothic Studies, and on Gothic fiction’s own decolonising possibilities. The article concludes by introducing the essays collected in the special issue, foregrounding how each takes up the questions of decoloniality and decolonising in relation to gothic imaginaries from different regions of the world.
Integridad Científica en Medicina y Cirugía
Authors: Haro-Haro Daniel Enrique
Published: November 2022

Hacemos una revisión de la integridad científica en medicina y cirugía, con énfasis en la buena conducta en toda investigación y en la promoción de la cultura de los valores y principios para aplicarlos al quehacer científico. Revisamos las prácticas cuestionables en la investigación médica, incluyendo al plagio que pone en riesgo el valor de honestidad y el respeto por la producción científica ajena.
PENGEMBANGAN WEBSITE PENDUKUNG MASTERY BASED LEARNING UNTUK PEMBELAJARAN MAHASISWA
Authors: Arhandi Putra Prima , Arief Sofyan Noor , Firdausi Annisa Taufika
Published: November 2022

Dampak wabah COVID-19 sangat berpengaruh pada sektor pendidikan, salah satunya pada mahasiswa Jurusan Teknologi Informasi di Politeknik Negeri Malang. Alur pembelajaran daring yang berjalan saat ini kurang efektif, sehingga mengakibatkan pembelajaran mahasiswa menjadi kurang maksimal. Oleh karena itu, diperlukan metode pembelajaran yang lebih efektif untuk diterapkan pada masa pembelajaran daring saat ini, salah satunya dengan menggunakan metode Mastery Based Learning (pembelajaran tuntas), di mana metode tersebut menargetkan mahasiswa untuk memahami suatu standar kompetensi secara tuntas dengan waktu yang bisa disesuaikan masing-masing mahasiswa. Pada pengembangan website ini, pengembang merancang suatu sistem pembelajaran daring yang menerapkan metode Mastery Based Learning untuk menunjang pembelajaran mahasiswa Jurusan Teknologi Informasi. Dengan menerapkan metode ini, mahasiswa yang memiliki pemahaman di bawah rata-rata tetap dapat mengikuti materi. Hasil dari pengujian sistem pembelajaran daring ini mendapatkan respon positif dari para mahasiswa. Dari 22 responden, semua setuju bahwa fitur-fitur yang tersedia dapat membuat pembelajaran mereka terbantu, yang artinya website pendukung metode Mastery Based Learning yang dibuat dapat diterima oleh mahasiswa sebagai alat bantu pembelajaran yang efektif untuk diterapkan.
Subthalamic Nucleus Deep Brain Stimulation for Dystonia: Evidence, Pros and Cons
Authors: Kilbane Camilla , Ostrem Jill L.
Published: November 2022

The primary target for deep brain stimulation (DBS) for medication refractory dystonia has traditionally been the globus pallidus internus (GPi), however alternate targets have also been explored with the hope they might offer similar or superior outcomes with less side effects and reduced battery demands. Recent studies have shown comparable outcomes with both pallidal and subthalamic (STN) DBS, although the level of evidence is still superior for the GPi. There may not be an “optimal target” for all dystonia patients, with both targets offering the potential for excellent control of dystonia but more comparison studies are needed. In this review, we will discuss the history, efficacy, as well as target specific benefits and possible side effects of STN DBS for dystonia.
The impact of early life maternal deprivation on the perineuronal nets in the prefrontal cortex and hippocampus of young adult rats
Authors: Jakovljevic Ana , Agatonovic Gorana , Aleksic Dubravka , Aksic Milan , Reiss Gebhard , Förster Eckart , Stamatakis Antonios , Jakovcevski Igor , Poleksic Joko
Published: November 2022

Early life stress negatively impacts brain development and affects structure and function of parvalbumin immunopositive (PV+) inhibitory neurons. Main regulators of PV+ interneurons activity and plasticity are perineuronal nets (PNNs), an extracellular matrix formation that enwraps PV+ interneurons mainly in the neocortex and hippocampus. To experimentally address the impact of early life stress on the PNNs and PV+ interneurons in the medial prefrontal cortex and dorsal hippocampus in rats, we employed a 24 h maternal deprivation protocol. We show that maternal deprivation in the medial prefrontal cortex of adult rats caused a decrease in density of overall PNNs and PNNs that enwrap PV+ interneurons in the rostral cingulate cortex. Furthermore, a staining intensity decrease of overall PNNs and PNN+/PV+ cells was found in the prelimbic cortex. Finally, a decrease in both intensity and density of overall PNNs and PNNs surrounding PV+ cells was observed in the infralimbic cortex, together with increase in the intensity of VGAT inhibitory puncta. Surprisingly, maternal deprivation did not cause any changes in the density of PV+ interneurons in the mPFC, neither had it affected PNNs and PV+ interneurons in the hippocampus. Taken together, our findings indicate that PNNs, specifically the ones enwrapping PV+ interneurons in the medial prefrontal cortex, are affected by early life stress.
Pan-cancer analyses reveal multi-omics and clinical characteristics of RIO kinase 2 in cancer
Authors: Li Kexin , Zou Jiahua , Yan Haizhao , Li Yuqing , Li Man-Mei , Liu Zhong
Published: November 2022

RIO kinase 2 has emerged as a critical kinase for ribosome maturation, and recently it has also been found to play a fundamental role in cancer, being involved in the occurrence and progression of glioblastoma, liver cancer, prostate cancer, non-small cell lung cancer, and acute myeloid leukemia. However, our knowledge in this regard is fragmented and limited and it is difficult to determine the exact role of RIO kinase 2 in tumors. Here, we conducted an integrated pan-cancer analysis comprising 33 cancer-types to determine the function of RIO kinase 2 in malignancies. The results show that RIO kinase 2 is highly expressed in all types of cancer and is significantly associated with tumor survival, metastasis, and immune cell infiltration. Moreover, RIO kinase 2 alteration via DNA methylation, and protein phosphorylation are involved in tumorigenesis. In summary, RIO kinase two serves as a promising target for the identification of cancer and increases our understanding of tumorigenesis and cancer progression and enhancing the ultimate goal of improved treatment for these diseases.
Design strategies for composite matrix and multifunctional polymeric scaffolds with enhanced bioactivity for bone tissue engineering
Authors: Kumari Shikha , Katiyar Soumya , Darshna  , Anand Aditya , Singh Divakar , Singh Bhisham Narayan , Mallick Sarada Prasanna , Mishra Abha , Srivastava Pradeep
Published: November 2022

Over the past few decades, various bioactive material-based scaffolds were investigated and researchers across the globe are actively involved in establishing a potential state-of-the-art for bone tissue engineering applications, wherein several disciplines like clinical medicine, materials science, and biotechnology are involved. The present review article’s main aim is to focus on repairing and restoring bone tissue defects by enhancing the bioactivity of fabricated bone tissue scaffolds and providing a suitable microenvironment for the bone cells to fasten the healing process. It deals with the various surface modification strategies and smart composite materials development that are involved in the treatment of bone tissue defects. Orthopaedic researchers and clinicians constantly focus on developing strategies that can naturally imitate not only the bone tissue architecture but also its functional properties to modulate cellular behaviour to facilitate bridging, callus formation and osteogenesis at critical bone defects. This review summarizes the currently available polymeric composite matrices and the methods to improve their bioactivity for bone tissue regeneration effectively.
Succinate aggravates intestinal injury in mice with necrotizing enterocolitis
Authors: Yan Xiao-Lin , Liu Xiao-Chen , Zhang Yu-Ni , Du Ting-Ting , Ai Qing , Gao Xiong , Yang Jing-Li , Bao Lei , Li Lu-Quan
Published: November 2022

Background

Necrotizing enterocolitis (NEC) is the most prevalent gastrointestinal disorder that predominantly threatens preterm newborns. Succinate is an emerging metabolic signaling molecule that was recently studied in relation to the regulation of intestinal immunity and homeostasis. We aimed to investigate the relationship between NEC and gut luminal succinate and preliminarily explored the effect of succinate on NEC pathogenesis.

Methods

Fecal samples from human neonates and mouse pups were analyzed by HPLC – MS/MS and 16S rRNA gene sequencing. C57BL/6 mice were randomly divided into four groups: control, NEC, Lsuc, and Hsuc. The mortality, weight gain, and intestinal pathological changes in four mouse groups were observed. Inflammatory cytokines and markers of macrophages were identified by quantitative real-time PCR. Succinate receptor 1 (SUCNR1) localization was visualized by immunohistochemistry. The protein levels of SUCNR1 and hypoxia-inducible factor 1a (HIF-1a) were quantified by western blotting.

Results

The levels of succinate in feces from NEC patients were higher than those in feces from non-NEC patients (P <0.05). In the murine models, succinate levels in intestinal content samples were also higher in the NEC group than in the control group (P <0.05). The change in succinate level was closely related to intestinal flora composition. In samples from human neonates, relative to the control group, the NEC group showed a higher abundance of Enterobacteriaceae and a lower abundance of Lactobacillaceae and Lactobacillus (P <0.05). In the murine models, relative to the control group, increased abundance was observed for Clostridiaceae, Enterococcaceae, Clostridium_sensu_stricto_1, and Enterococcus, whereas decreased abundance was observed for Lactobacillaceae and Lactobacillus (P <0.05). Increased succinate levels prevented mice from gaining weight, damaged their intestines, and increased their mortality; upregulated the gene expression of interleukin-1β (IL-1β), IL-6, IL-18 and tumor necrosis factor (TNF); and downregulated the gene expression of IL-10 and transforming growth factor (TGF)-β. Exogenous succinic acid increased inducible nitric oxide synthase (iNOS) gene expression but decreased Arginase-1 (Arg1) gene expression; and increased the protein expression of SUCNR1 and HIF-1a.

Conclusion

Succinate plays an important role in the development of necrotizing enterocolitis severity, and the activation of the HIF-1a signaling pathway may lead to disease progression.
Mechanisms of persistent atrial fibrillation and recurrences within 12 months post-ablation: Non-invasive mapping with electrocardiographic imaging
Authors: Vijayakumar Ramya , Faddis Mitchell N. , Cuculich Phillip S. , Rudy Yoram
Published: November 2022

Introduction

Catheter ablation of persistent AF has not been consistently successful in terminating AF or preventing arrhythmia recurrences. Non-invasive Electrocardiographic Imaging (ECGI) can help to understand recurrences by mapping the mechanisms of pre-ablation AF and comparing them with the patterns of recurrent arrhythmias in the same patient.

Methods

Seventeen persistent AF patients underwent ECGI before their first catheter ablation. Time-domain activation maps and phase progression maps were obtained on the bi-atrial epicardium. Location of arrhythmogenic drivers were annotated on the bi-atrial anatomy. Activation and phase movies were examined to understand the wavefront dynamics during AF. Eight patients recurred within 12 months of ablation and underwent a follow-up ECGI. Driver locations and movies were compared for pre- and post-ablation AF.

Results

A total of 243 focal drivers were mapped during pre-ablation AF. 62% of the drivers were mapped in the left atrium (LA). The pulmonary vein region harbored most of the drivers (43%). 35% of the drivers were mapped in the right atrium (RA). 59% (10/17) and 53% (9/17) of patients had repetitive sources in the left pulmonary veins (LPV) and left atrial appendage (LAA), and the lower half of RA, respectively. All patients had focal drivers. 29% (5/17) of patients had macro-reentry waves. 24% (4/17) of patients had rotors. Activation patterns during persistent AF varied from single macro-reentry to complex activity with multiple simultaneous wavefronts in both atria, resulting in frequent wave collisions. A total of 76 focal driver activities were mapped in 7/8 patients during recurrence. 59% of the post-ablation AF drivers were mapped in the LA. The pulmonary vein region harbored 50% of total drivers. 39% of sources were mapped in the RA. AF complexity remained similar post-ablation. 58% (44/76) of pre-ablation sources persisted during recurrence. 38% (3/8) of patients had macro-reentry and one patient had rotors.

Conclusion

ECGI provides patient-specific information on mechanisms of persistent AF and recurrent arrhythmia. More than half pre-ablation sources repeated during post-ablation recurrence. This study provides direct evidence for drivers that persist days and months after the ablation procedure. Patient-tailored bi-atrial ablation is needed to successfully target persistent AF and prevent recurrence. ECGI can potentially predict recurrence and assist in choice of therapy.