bluuebunny/crossref_metadata_2025 huggingface dataset:
Forecasting Chinese Carbon Emissions from Fossil Energy Based on the Fractional Order Cumulative Multivariate Grey Model
Authors: Zhang Yunxin , Guo Huan , Xiong Xin
Published: August 2022

In the process of Chinese economic development shifting from a stage of high‐speed growth to a stage of high‐quality development, carbon emissions caused by fossil energy consumption are also increasing. To reflect the interaction between Chinese carbon emissions from fossil energy consumption and economic growth, this paper constructed the fractional order cumulative multivariate gray model with equal‐dimensional recursive optimization (EFMGM(1,2)) to predict the trend of carbon emissions from fossil energy consumption and constant price GDP in China and calculated the carbon emissions from fossil energy consumption according to the IPCC accounting method. EFMGM(1,2) is compared with other gray models to verify the performance of the model. The results show that this model has better prediction performance than other models. It can be used as an effective method for forecasting carbon emissions from fossil energy.
Clinical Study of Different Treatment Methods for Tuberculous Pleuritis Complicated with Pleural Tuberculoma
Authors: Zhang Xiaoling , Chi Jingyu
Published: August 2022

Objective. To compare the clinical efficacy and adverse drug reactions of four different schemes in the treatment of pleural tuberculoma. Methods. A total of 120 patients with pleural tuberculoma admitted to the Tuberculosis Department of our hospital from January 2018 to January 2021 were selected as the research subjects. According to different treatment methods, the patients were divided into four groups, with 30 cases in each group. They were as follows: group A received classical HRZE regimen, group B received HRZE+pleural injection, group C received HZE+rifabutin, and group D received HZE+rifabutin+pleural injection. All patients were treated intensively for 3 months and then consolidated treatment for 6 months according to the patient’s condition. The absorption of lesions in the four groups at different time was compared, and the occurrences of adverse drug reactions and treatment outcomes during treatment were recorded. Results. After 3 months of treatment, compared with groups A, B, and C, the number of significantly absorbed cases and effective cases in group D increased, while the number of invalid cases decreased. However, there was no statistical significance in the absorption of lesions between the four groups (

χ

2

=
8.272

,

P
=
0.507

). In addition, pairwise comparison showed no significant difference in the absorption of lesions (

P
>
0.05

). After 9 months of treatment, there was no significant difference in the absorption of lesions among the four groups (

χ

2

=
8.795

,

P
=
0.185

), but the absorption of lesions in group D was significantly better than that in group A (

P
<
0.05

). During treatment, the incidence of adverse reactions in the four groups was significantly different (

χ

2

=
8.779

,

P
=
0.032

). Pairwise comparison showed that the incidence of adverse reactions in groups C and D was significantly lower than that in group A (

P
<
0.05

). The total treatment course of group A was 9-16 months, and 10 cases (33.33%) still had residual lesions or pleural thickening at the end of treatment. The total course of treatment in group B was 9-12 months, and 7 cases (23.33%) still had residual lesions or pleural thickening at the end of the course of treatment. The total treatment course of group C was 9-16 months, and 8 cases (26.67%) still had residual lesions or pleural thickening at the end of treatment. The total course of treatment in group D was 9-12months, and there were still 2 cases of residual lesions (6.67%) at the end of the course. Conclusions. HZE+rifabutin+pleural injection against tuberculosis therapy has a significant clinical efficacy in the treatment of pleural tuberculoma, which can more effectively improve the clinical symptoms of patients, improve the efficacy, and reduce complications, with a good prognosis, worthy of clinical promotion.
Experimental and Computational Approaches for the Classification and Correlation of Temperament (Mizaj) and Uterine Dystemperament (Su’-I-Mizaj Al-Rahim) in Abnormal Vaginal Discharge (Sayalan Al-Rahim) Based on Clinical Analysis Using Support Vector Machine
Authors: Sultana Arshiya , Begum Wajeeha , Saeedi Rushda , Rahman Khaleequr , Bin Heyat Md Belal , Akhtar Faijan , Son Ngo Tung , Ullah Hadaate
Published: August 2022

The temperament (Mizaj) of the body is an essential constituent for health conservancy and diagnosis of several diseases. Hence, general body temperament and uterine dystemperament (Su’-i-Mizaj) with abnormal vaginal discharge (Salayan al-Rahim) need evaluation. In addition, we also applied a computational intelligence technique for enhancing scientific validity to classify the warm‐cold and wet‐dry temperaments. This trial included a total of 66 participants with a vaginal discharge of reproductive age. Data included demographic characteristics of the participants, symptoms associated with vaginal discharge, women’s general temperament, and symptoms of uterine dystemperament. Correlation between general body temperament and age, abnormal vaginal discharge, and its associated symptoms was also performed. Additionally, we used the Support Vector Machine‐Radial Basis Function (SVM‐RBF) model to classify the warm‐cold and wet‐dry temperaments. Warm general temperament was highly prevalent (77.27%), followed by moderate (19.69%) on the warm‐cold temperament scale. In wet‐dry temperament, moderate general body temperament (50%) was more prevalent. In warm‐cold and wet‐dry scores, 78.78% and 74.24% had warm and wet uterine dystemperament, respectively. The age and symptoms were correlated with general temperament. A strong positive correlation was found between warm general temperament and warm dystemperament of the uterus (r = 0.40, p < 0.009). In addition, our SVM‐RBF CV‐5 classification model achieved the highest accuracy (99.2%). Our results showed that vaginal discharge is more common in warm general temperament and warm‐wet dystemperament of the uterus. The same has been proven by computational intelligence. Nevertheless, vaginal discharge can also happen in normal and other temperaments.
Advanced Artificial Intelligence and Big Data Algorithm in Aerobics Formation Transformation Route Simulation Research
Authors: Shou Minchao , Ma Chao , Che Lei
Published: August 2022

Aerobics formation is a type of sport that can be performed for long periods with the aid of music. Traditional aerobic sports have influenced the development of the competitive aerobics training service project, which has racing as one of its primary goals. Transformation of aerobics training uses seven fundamental steps, diverse dynamics, and complete execution of challenging exercises to display the competitive athletics abilities of health, strength, and beauty. The challenging characteristics of aerobics formation transformation route simulation include aerobic fitness level from the beginning, the intensity of training, frequency of coaching, condition of heart disease, blood pressure, high distance running, and increasing repeated exercise, which can develop significant problems. This paper introduces an advanced artificial intelligence (AI) assisted by big data algorithm (BD) for the simulation of aerobics formation (AF) to enhance overall fitness; cardio is a sort of activity that involves physical endurance with flexibility and muscle toning. The research of AIBD-AF has many advantages like reducing the danger to your health and strengthening the heart’s muscular fibers with stamina. It is good for cardiovascular arteries since it removes clogs. The immune system is expanded, and aids in better managing long-term ailments and also keeps the body fit as you get older and weaker. In addition to improving fitness levels, aerobics also helps to teach the heart and lungs to carry oxygen to the entire body more effectively.
Collaborative Innovation Mechanism of Water Pollution Control Industry Chain Based on Complex Scientific Management
Authors: Yuan Quan , Peng Ting , Ming Junren
Published: August 2022

In the process of collaborative innovation of water pollution control industry chain, there are some problems, such as chain break and lack of chain, which lead to poor effect of water pollution collaborative governance and low economic benefits. Therefore, this paper proposes a research method of collaborative innovation mechanism of water pollution treatment industry chain based on complex scientific management. In view of the problems existing in the current industrial chain of water pollution control, the collaborative economic model and matter‐element extension model of the industrial chain of water pollution treatment are constructed to improve the synergy effect of each link in the industrial chain and solve the contradictions of each link in the coordination process, so as to provide guarantee for the collaborative innovation of the industrial chain of water pollution control. The experimental results show that the proposed method can bring high economic benefits in the stage of source emission reduction, process interruption, and end treatment, and the water pollution treatment effect is good, which fully verifies the practical application effect of the method. After using the design method to purify, the maximum purification rate reaches more than 80%, and the purification effect reaches class v. The effect is remarkable, which has practical application value.
Six MicroRNA Prognostic Models for Overall Survival of Lung Adenocarcinoma
Authors: Li Juan , Gu Xuyu , Gao Chanchan , Zhang Jun
Published: August 2022

Objective. The purpose of this study is to screen for microRNAs (miRNAs) associated with the prognosis of lung adenocarcinoma (LUAD) and to explore its prognosis and effects on the tumor microenvironment in patients with LUAD. Methods. Gene expression data, miRNA expression data, and clinical data for two different databases, TCGA-LUAD and CPTAC-3 LUAD, were downloaded from the GDC database. The miRNA prognosis of LUAD was filtered by the Cox proportional hazard model and the Least Absolute Shrinkage and Selection Operator (LASSO) regression model. The performance of the model was validated by time-dependent receiver operating characteristics (ROC) curves. Possible biological processes associated with the miRNAs target gene were analyzed through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Finally, the prognostic model was scored by risk, divided into high- and low-risk groups by median, and the differences in the immersion level of 21 immune cells in the high- and low-risk groups were assessed. To gain a deeper understanding of the underlying mechanism behind the model, the two most important miRNAs in the model, miR-195-3p and miR-5571-5p, were selected for HPA database validation and ceRNA network construction. Results. Of the 209 variance expressions identified in the screening analysis, 145 were upregulated and 64 were downregulated by miRNAs. The prognostic models of six miRNA genes were obtained: miR-195-3p, miR-5571-5p, miR-584-3p, miR-494-3p, miR-4664-3p, and miR-1293. These six genes were significantly associated with survival rates in LUAD patients. In particular, miR-1293, miR-195-3p, and miR-5571-5p are highly correlated with OS. The higher expression of miR-195-3p and miR-5571-5p, the better survival of LUAD OS is, and these two miRNA expressions contribute the most to the model. Finally, after sorting the risk scores calculated from low to high using the prognostic model, the patients with higher scores had shorter survival time and higher frequency of death, and there were significant differences in the immersion levels of 21 immune cells in the high- and low-risk groups. ceRNA network analysis found that TM9SF3 was regulated by miR-195-3p and was highly expressed in the tissues of LUAD patients, and the prognosis of the patients was poor. Conclusions. miR-195-3p, miR-5571-5p, miR-584-3p, miR-494-3p, miR-4664-3p, and miR-1293 may be used as new biomarkers for prognosis prediction of LUAD. Our results also identified a lncRNA MEG3/miR-195-3p/RAB1A/TM9SF3 regulatory axis, which may also play an important role in the progression of LUAD. Further study needs to be conducted to verify this result.
The Teaching Mode of Martial Arts in Colleges and Universities Based on Artificial Intelligence Assistance
Authors: Xu Meng , Li Hao , Zhu Yacheng
Published: August 2022

Artificial intelligence, as one of the important representatives of information technology development, gradually penetrates into all fields of education and teaching, and the forms of education and teaching become diversified. Teaching with the core of students’ core literacy cultivation and digital transformation as the background has produced incompatibility with the current development in terms of teaching purpose, teaching value, teaching methods, and teaching ability, which has become an obstacle to the development and reform of education and teaching. In the current era, we should do a good job of integrating information technology and education teaching, transforming traditional teaching habits, focusing on the core value of teaching, and realizing the transformation from teaching to learning in the context of digitalization. The development of artificial intelligence way education refers to the use of new technology to promote talent training, so that the traditional education and teaching methods are changed to form a new education form of intelligent learning, interactive learning, and deep learning.
The Extropy of Concomitants of Generalized Order Statistics from Huang–Kotz–Morgenstern Bivariate Distribution
Authors: Husseiny I. A. , Syam A. H.
Published: August 2022

In this paper, we study the extropy for concomitants of m−generalized order statistics (m−GOSs) from Huang–Kotz–Farlie–Gumbel–Morgenstern (HK‐FGM) bivariate distribution. Moreover, the cumulative residual extropy (CREX) and negative cumulative extropy (NCEX) are depicted. Furthermore, the empirical technique in conjunction with the concomitant of m−GOS is used to investigate the problem of estimating the CREX and NCEX. The concomitants of order statistics and record values are offered as some applications of these findings.
Early Assessment of Cardiac Function by Echocardiography in Patients with Gestational Diabetes Mellitus
Authors: Wang Pin , Peng Yanyan , Liu LiNa , Jiao RuiShuang , Zhang YanHong , Zhao Wei , Liu YingFeng , Sun CongXin
Published: August 2022

Objective. To offer a baseline for clinical diagnosis, echocardiography was performed to evaluate the disparities in heart function comparing pregnant women with diabetes mellitus (GDM) and ordinary pregnant women. Methods. A prospective case-control study is being conducted on pregnant women with or without gestational diabetes. The sample size for both the intervention and control groups is the same: no diabetes diagnosis or previous forms, a single pregnancy, and no issues (such as preeclampsia or fetal growth restriction). The females were all subjected to routine echocardiograms to examine the morphology and function of their left and right hearts. Results. In the research, 51 women with GDM and 50 healthy controls volunteered. Women with GDM had a significantly higher heartrate (

82
±
9

vs.

74
±
8

), left ventricular (LV) relative wall thickness (

0.39
±
0.06

vs.

0.31
±
0.07

;

P
<
0.001

), LV early diastolic transmitral valve velocity (E) (

0.79
±
0.14

vs.

0.72
±
0.13

 m/s;

P
=
0.031

), and LV late diastolic implementing regulations valve velocity (0.6). Speckle-tracking analysis showed significant decrease in LV right ventricular (RV). A study indicated a reduced pulmonary acceleration time (

59
±
9

vs. 68 ± 12 ms;

P
=
0.001

), RV E/A ratio (

1.21
±
0.19

vs.

1.31
±
0.31

;

P
=
0.022

), and a greater RV myocardial systolic annular velocity (

0.17
±
0.03

vs.

0.12
±
0.03

;

P
=
0.023

). Conclusions. Our results revealed that the heart function of diabetic pregnant women differed considerably from that of the control group, such as LV-RWT, LV diastolic transmitral valve speed, and LV late diastolic transmitral valve speed. Given these results, further research into the postpartum cardiovascular healing of pregnant women with gestational diabetes mellitus is required.
Modeling Design of Ceramic Products Based on Digital Image Processing Technology
Authors: Lu Yongqing
Published: August 2022

With the improvement of people’s living standards, people’s pursuit of art is also getting higher and higher. Ceramic products are artistic works whose meanings contain thousands of stories including mountains, waters, and rivers. Ceramic products include vases, tea sets, flower pots, plates, and rice bowls. A vase is a vessel, mostly made of ceramic or glass, with a beautiful and smooth appearance. The bottom of the vase usually holds water, which keeps the plants alive and beautiful. Tea utensils refer to tea-drinking utensils such as tea cups, teapots, tea bowls, tea cups, saucers, and tea trays in a narrow sense. There are many kinds of tea sets in China, with beautiful shapes. In addition to practical value, they also have high artistic value, so they are well known at home and abroad and are favored by tea lovers in all dynasties. Digital image processing is the use of computers to remove noise and enhance, restore, segment, and extract features from images. Discrete mathematics is a mathematical subject that studies the structure of discrete quantities and their interrelationships and is an important branch of modern mathematics. The meaning of discrete refers to different elements connected together, mainly to study the structure and mutual relationship based on discrete quantities. Its objects are generally limited or countable elements. With the continuous development of digital image processing technology, this technology has also been applied to the shape design of ceramic products. This paper mainly conducts in-depth research on the preprocessing algorithm of digital images, from the initial analysis of the historical culture of the process to the subsequent algorithm research. Then its accuracy is matched to make a comparison, and finally an estimate based on the ceramics studied in this paper will be made. In the experimental part, the public is first investigated and analyzed, and the conclusion shows that the results of the color investigation of ceramic products include the following aspects: There are about 103 people having more needs for light and elegant color feeling, which echoes the needs of modeling. There are around 97 people demanding that the color be combined with the shape to reflect the color difference between the interior and the exterior. Since the internal and external chromatic aberration and mixed colors will bring novelty to the appearance of ceramic products, there are also a large number of people in the demand for mixed colors, about 84 people. Then it is analyzed that the ink-and-wash ceramics in the landscape style are more popular, and then the detailed description is carried out. Finally, the finished product is displayed.
Enhancement of Congo Red-Neomycin Resonance Rayleigh Scattering by Dodecyl Trimethyl Ammonium Bromide and its Application
Authors: Zhang Fanfan , Chen Yangyang , Zhang Dan , Jia Yang , Meng Junsheng , Jiang Lirong , Yang Shengke
Published: August 2022

A simple, rapid, and convenient method for the determination of neomycin based on the ion association method was proposed. In Britton–Robinson buffer solution, neomycin could react with Congo red to form an ionic association, which in turn reacted with dodecyl trimethyl ammonium bromide to form a ternary ionic association. The three were combined in a 1 : 1 : 1 ratio, which significantly enhanced the resonant Rayleigh scattering intensity at 468 nm. The obtained resonant Rayleigh scattering sensor showed a linear relationship with neomycin in the range of 0.07∼1 μg·mL−1. The limit of detection was 0.02 μg·mL−1, and the limit of quantification was 0.037 μg·mL−1. The experimental conditions were optimized. The method was verified based on the ICH rule. The established method could be applied to the analysis of the acceptable recovery rate of neomycin in powdered veterinary drugs.
[Retracted] The Innovative Trend of Piano Teaching in Music Education in Multicultural Education under Ecological Environment
Authors: Lu Yuan
Published: August 2022

Primarily based on theoretical studies of multicultural pedagogy, anthropology of music, and postmodern music education concepts, techniques combining qualitative and quantitative research are used. Eight types of design guidelines are then proposed according to different intelligence characteristics, according to intelligence characteristics and context of conversational design. Finally, based on the perspective of multicultural learning environments, this work will explore and provide insights into new concepts of piano teaching in multicultural learning environments in three areas: new piano teaching, new instruction, and new piano learning materials. The experimental results show that piano teaching activities based on multiple intelligences theory can stimulate students’ interest in learning music, fully mobilize students’ initiative in learning music, and improve the quality of music teaching.
Correlation between the Immune Checkpoint Inhibitors Prognostic Index and Outcomes in Nonsmall Cell Lung Cancer: A Multicentre Analysis
Authors: Zhou Ying , Wu Bin , Li Tian , Zhang Yong , Xu Tianqi , Chang Ning , Zhang Jian
Published: August 2022

Objective. To evaluate the prognostic value of the immune checkpoint inhibitor prognostic index (ICPI), based on the albumin (ALB) and derived neutrophil-to-lymphocyte ratio (dNLR), for nonsmall cell lung cancer (NSCLC) patients receiving immune checkpoint inhibitors (ICIs). Methods. We conducted a multicentre retrospective study with an ICIs cohort (n = 143) and a chemotherapy control cohort (n = 84). A Cox proportional hazards regression and logistic regression model were used to find the independent risk factor for progression-free survival (PFS) and overall survival (OS) and disease control rate (DCR) in NSCLC patients. The Kaplan–Meier was used to evaluating the PFS and OS. Results. The ALB <35 g/L and dNLR >3 were correlated with worse PFS and OS for NSCLC patients receiving ICIs, respectively. The moderately high-risk ICPI had a significantly increased risk of progression (hazard ratio (HR) 1.83, 95% confidence interval (CI) 1.14–2.91;

P
=
0.012

) and of death (HR 2.33, 95% CI 1.12–4.87;

P
=
0.024

) and of nondisease control (odds ratio (OR) 3.05, 95% CI 1.19–7.83;

P
=
0.021

) and was correlated with worse PFS and 1-year survival rates (4.0 months vs. 7.2 months;

P
=
0.001

; 44.3% vs. 76.1%;

P
=
0.001

) compared with low-risk ICPI when it was characterized two groups. When ICPI was further divided into three groups, the results showed that the high-risk ICPI was correlated with worse PFS and 1-year survival rates. However, there was no difference in the chemotherapy cohort. Conclusion. The ICPI was correlated with worse outcomes for NSCLC patients receiving ICIs but not for patients with chemotherapy.
CircRNA-Associated ceRNA Network Reveals Focal Adhesion and Metabolism Pathways in Neuropathic Pain
Authors: Wang Kun , Bao Jun-Ping , Zhou Zhi-Min , Mao Lu , Wu Xiao-Tao
Published: August 2022

Background. Increasing evidence has shown that noncoding RNAs perform a remarkable function in neuropathic pain (NP); nonetheless, the mechanisms underlying the modulation of competitive endogenous RNA in NP remain uncertain. The goal of this research was to investigate the molecular processes underlying NP. Methods. We utilized the Gene Expression Omnibus (GEO) to obtain NP-related microarray datasets that included the expression patterns of circular RNAs (circRNAs) and messenger RNAs (mRNAs). Following that, bioinformatics analyses and a molecular biology experiment were carried out. Results. According to the findings, carrying out enrichment studies of the targeted genes had an impact on a variety of NP-related pathways. Notably, we isolated a ceRNA subnetwork incorporating two upregulated circRNAs (Esrrg and Map3k3) which primarily participate in the focal adhesion pathway by regulating Integrin Subunit Beta 4 (ITGB4) and two downregulated circRNAs (Dgkb and Atp2a2), which potentially regulate metabolism-related molecule Lipase A (LIPA). Conclusions. According to our findings, the focal adhesion and metabolic signaling pathways could be critical in the advancement of NP, and some circRNA might regulate this biological process through the ceRNA network, which might offer pertinent insights into the underlying mechanisms.
Effect of Local Warm Compression on Restless Leg Syndrome and Fatigue among Critical Care Nurses: A Parallel Randomized Clinical Trial
Authors: Ameri Maryam , Ebrahimi Hossein , Khosravi Ahmad , Mirhosseini Seyedmohammad , Khatibi Mohammad Reza
Published: August 2022

Background and Aim. Fatigue and restless leg syndrome are common complications in critical care nurses (CCNs). The present study aimed to investigate the effect of local warm compression on restless leg syndrome and fatigue in CCNs. Methods and Materials. This parallel randomized clinical trial was conducted on 120 CCNs in Shahroud by the census sampling method. Inclusion criteria included suffering from restless leg syndrome and having no wound or inflammation over the organ. The participants were assigned into two groups by the use of quadruple blocks. The intervention group received the warm compress for 12 sessions lasting 4 weeks and the control group did not receive an intervention. Data were collected using multidimensional fatigue inventory (MFI) and the Restless Legs Syndrome Scale and then analyzed using descriptive and inferential statistics (chi-squared test, independent sample t-test, and pair sample t-test). Results. The two groups were homogeneous in terms of demographic characteristics. Prior to the intervention, the two groups of warm compression and control did not have a significant difference in terms of mean fatigue and restless leg syndrome scores; however, after the intervention, a significant reduction was observed in the intervention group (

p
<
0.001

). Conclusion. According to the results of the current study, the use of warm compression is an effective intervention in alleviating fatigue and restless leg syndrome, so it is recommended to implement this intervention as a nonpharmacological strategy among CCNs. Clinical Trial Registration Number. IRCT20190723044316N1.
Molecular Modeling Guided Drug Designing for the Therapeutic Treatment of Rheumatoid Arthritis
Authors: Imran Maheen , Nasir Muhammad Hassan , Attique Syed Awais , Baig Atif Amin , Ain Qurat Ul , Usman Muhammad , Munir Muzna , Rathore Hassaan Anwer
Published: August 2022

Rheumatoid arthritis (RA) is a systemic inflammatory disorder that can cause destructive joint disease, significant disability, and increased mortality. RA is the most frequent of all chronic inflammatory joint diseases, and its prevalence frequency in Pakistan is 1.6 per thousand people. Different cytokines and receptors were involved in the triggering of RA, including interleukin-6 (ILR-6), major histocompatibility complex (MHC) antigen human leukocyte (HLA-DR) receptor, and CD20. Several studies illustrated RA as an inherent immune response and triggered due to the “shared epitope.” Therefore, the involvement of all these receptors (IL-6, HLA-DR, and CD20) leads to the neurological, ocular, respiratory, cardiac, skin, and hematological manifestations that have been considered a potential therapeutic target for drug design. Various herbal, natural, and synthetic source inhibitors of interleukin-6 (IL-6), human leukocyte (HLA-DR), and CD20 were studied and reported previously. Reported inhibitors are compared to elucidate the best inhibitor for clinical trials, leading to the orally active drug. In this study, a computer-aided drug designing approach disclosed the potential inhibitors for all receptors based on their distinct binding affinity. Moreover, drug suitability was carried out using Lipinski’s rule by considering the adsorption, distribution, metabolism, and excretion (ADME) of ligands. Results elucidated “calycosin 7-O-glucoside” and “angeliferulate” as putative ligands for IL-6 and HLA-DR, respectively. However, the pharmacokinetic properties (ADMET) revealed angeliferulate as an effete ligand for the biological system compared to calycosin 7-O-glucoside. Based on docking, drug toxicity profiling or pharmacokinetics, and MD simulation stability, this study highlights orally active therapeutic inhibitors to inhibit the activity of pivotal receptors (IL6, HLA-DR, and CD20) of RA in humans. After clinical trials, the resultant inhibitors could be potential therapeutic agents in the drug development against RA.
Dynamic Evaluation of Carbon Emission Performance of New Energy Enterprises based on Orthogonal Projection Method
Authors: Wang Tinggui , Li Hemei
Published: August 2022

The rapid development of economic society causes people to increase the energy demand, produce more and more carbon dioxide, environmental pollution is becoming more and more serious, to solve the problem of carbon peak is imminent. Under the same and complete evaluation system, the carbon emission performance varies slightly according to different R&D directions of new energy enterprises. Therefore, it is particularly important to select evaluation indicators. In fact, each enterprise has different efforts to control carbon emissions. While studying the performance of carbon emissions, the direct and indirect impacts of carbon dioxide produced by each enterprise in the process of production on the ecological environment should be considered. In order to guarantee systematic and scientific outcomes, carbon emissions performance evaluation indicator system for new energy enterprises is constructed. With new energy enterprises as examples, based on the construction of carbon emissions performance evaluation indicator system of new energy enterprises, orthogonal projection method is used to carry out an empirical analysis of the dynamic evaluation of carbon emissions performance of thirty new energy enterprises. Through the questionnaire survey of thirty new energy enterprises, the indicator weight of carbon emission performance evaluation of new energy enterprises was determined, and the carbon emission performance of new energy enterprises was analyzed. The results will reflect the actual situation of China’s new energy enterprises, and provide the data support and references for future research on carbon emission control by the country and enterprises.
On the Maximum Symmetric Division Deg Index of k‐Cyclic Graphs
Authors: Albalahi Abeer M. , Ali Akbar
Published: August 2022

Let G be a graph. Denote by du, the degree of a vertex u of G and represent by vw, the edge of G with the end‐vertices v and w. The sum of the quantities over all edges uv of G is known as the symmetric division deg (SDD) index of G. A connected graph with n vertices and n − 1 + k edges is known as a (connected)k‐cyclic graph. One of the results proved in this study is that the graph possessing the largest SDD index over the class of all connectedk‐cyclic graphs of a fixed order n must have the maximum degree n − 1. By utilizing this result, the graphs attaining the largest SDD index over the aforementioned class of graphs are determined for every k = 0,1, …, 5. Although, the deduced results, for k = 0,1,2, are already known, however, they are proved here in a shorter and an alternative way. Also, the deduced results, for k = 3,4,5, are new, and they provide answers to two open questions posed in the literature.
Gasdermin D Deficiency Does Not Protect Mice from High-Fat Diet-Induced Glucose Intolerance and Adipose Tissue Inflammation
Authors: Ma Eun Bi , Javaid Hafiz Muhammad Ahmad , Jung Do-Hyeon , Park Jong-Hwan , Huh Joo Young
Published: August 2022

The adipose tissue NLRP3 inflammasome has recently emerged as a contributor to obesity-related metabolic inflammation. Recent studies have demonstrated that the activation of the NLRP3 inflammasome cleaves gasdermin D (GSDMD) and induces pyroptosis, a proinflammatory programmed cell death. However, whether GSDMD is involved in the regulation of adipose tissue function and the development of obesity-induced metabolic disease remains unknown. The aim of the present study was to investigate the role of GSDMD in adipose tissue inflammation as well as whole-body metabolism using GSDMD-deficient mice fed a high-fat diet (HFD) for 30 weeks. The effects of GSDMD deficiency on adipose tissue, liver, and isolated macrophages from wild-type (WT) and GSDMD knockout (KO) mice were examined. In addition, 3T3-L1 cells were used to examine the expression of GSDMD during adipogenesis. The results demonstrate that although HFD-induced inflammation was partly ameliorated in isolated macrophages and liver, adipose tissue remained unaffected by GSDMD deficiency. Compared with the WT HFD mice, GSDMD KO HFD mice exhibited a mild increase in HFD-induced glucose intolerance with increased systemic and adipose tissue IL-1β levels. Interestingly, GSDMD deficiency caused accumulation of fat mass when challenged with HFD, partly by suppressing the expression of peroxisome proliferator-activated receptor gamma (PPARγ). The expression of GSDMD mRNA and protein was dramatically suppressed during adipocyte differentiation and was inversely correlated with PPARγ expression. Together, these findings indicate that GSDMD is not a prerequisite for HFD-induced adipose tissue inflammation and suggest a noncanonical function of GSDMD in regulation of fat mass through PPARγ.
Implementation of DOA Estimation System Based on HackRF One
Authors: Zhang Zihan , Zhao Wenjie , Huang Yonghui , An Junshe , Zhu Yan
Published: August 2022

In the practical direction of arrival (DOA) estimation applications, it is required that the multichannel signal acquisition equipment can synchronously collect the signals received by the array antenna. In addition, the signal phase relationships between channels are supposed to be stable. However, this kind of equipment is usually complex and expensive to manufacture. Since some SDR devices are reconfigurable and open source, this paper adopts HackRF Ones as the signal sampling devices to design the DOA estimation system. The clocks line is used to synchronize the clock frequencies between HackRF Ones. Besides, an external pulse is introduced to control the sampling devices to start sampling simultaneously. In this case, the stable phase difference between channels can be obtained. The experimental results show that the synchronization error between channels of the system is less than one sampling period. The system can be used to estimate the incident angles of single carrier signals or modulated signals. The RMS errors of the system when estimating one source and two sources are 1.94° and 2.85°, respectively.
[Retracted] Clinical Outcomes of Treatment Strategies for Postoperative Plate Fracture and In Situ Fracture of the Femoral Shaft
Authors: Tu Junbo , Jiang Haixiang , Li Cuihe , Huang Xiaowu , Li Xingwang
Published: August 2022

Objective. To investigate the treatment and clinical efficacy of postoperative plate fracture and in situ fracture of the femoral stem. Methods. We have retrospectively analyzed the clinical data, revised surgery information, and clinical efficacy of patients with postoperative plate fracture of the femoral stem in our hospital. A total of 33 cases were included whose original fractures were located in the upper and cadaveric femur and treated with paralleling intramedullary pins for revision surgery, as well as patients whose original fractures were located in the lower femur which were fixed with retrograde intramedullary nailing or anatomical locking and compression splints in the distal femur. For the selection of bone grafting, the original fracture site with Fernadez‐Esteve scab grades I and II was treated with an autologous iliac bone graft. Postoperatively, patients were evaluated for fracture healing time, the clinical outcome of the affected limb, and complications in the iliac bone donor area. Results. All patients were followed up until fracture healing, and all patients achieved clinical healing with a healing rate of 100% and a mean healing time of 6.3 months. No internal fixation failure such as rebreakage or loosening of the internal fixation occurred in all patients during the follow‐up period. According to the Tohner‐Wrnch criteria, 23 cases were excellent, 10 cases were good, and 0 cases were poor, with an excellent rate of 100%. Complications in the autologous iliac bone donor area amounted to 36.7%. Conclusion. For patients with original fractures located in the upper femoral segment or cadre, it is recommended to perform revision surgery with a paralleling intramedullary pin, while patients with original fractures located in the lower femoral segment are fixed with the retrograde intramedullary nailing or an anatomical type of distal femoral locking and compression splint. Patients with postoperative plate fractures of the femoral stem do not require routine autologous bone grafting for revision surgery.
Investigation on the Distribution Characteristics of Chinese Continuing Education Based on the Community Detection Algorithm in Complex Networks
Authors: Lai Yuping , Yuan Qin , Yu Qinming
Published: August 2022

In order to closely fit the characteristics of continuing education, the development of continuing education teaching activities under the network background should not only be combined with the characteristics of professional adult education but also make reasonable use of modern teaching models in the actual teaching process. Based on the community detection algorithm in complex networks, this article makes thorough research and analysis on the complexity of Chinese continuing education by using complex network technology. By establishing the characteristics of vertex degree distribution, average path length, and clustering coefficient of complex networks, it is confirmed that Chinese continuing education has scale-free network characteristics and small-world network characteristics. The three aspects of relationship strength comprehensively analyze the information dissemination speed, scope, interpretation, and application; through the combination of the ant colony algorithm and complex network technology, multiple information dissemination paths are abstracted in Chinese continuing education. The research shows that the application of complex network algorithms can effectively improve the speed and quality of continuing education in China. It is found that the government should increase the number of adult education projects and improve the level of project categories, form key adult education research basis to promote the diversification of research subjects, expand the space for adult education projects to balance regional and provincial differences and attach importance to basic research on adult education, and integrate applied research.
The Association of Seasonal Variations and COVID-19 Clinical Features: A Comparative Study on the Fourth and Fifth Waves
Authors: Karvandian Kasra , Tadbir Vajargah Kiana , Beigi Shabnam , Mohammadzadeh Narjes , Ashouri Mohammad , Samadi Shahram , Zamani Mohsen
Published: August 2022

Purpose. The COVID-19 pandemic has overwhelmed many healthcare systems. Seasonality is a feature of several infectious diseases. Studies regarding the association of seasonal variations and COVID-19 have shown controversial results. Therefore, we aimed to compare COVID-19 characteristics and survival outcomes between the fourth and fifth waves in Iran, which corresponded to spring and summer, respectively. Methods. This is a retrospective study on the fourth and fifth COVID-19 waves in Iran. One hundred patients from the fourth and 90 patients from the fifth wave were included. Data from the baseline and demographic characteristics, clinical, radiological, and laboratory findings, and hospital outcomes were compared between the fourth and fifth COVID-19 waves in hospitalized patients in Imam Khomeini Hospital Complex, Tehran, Iran. Results. The fifth wave patients were more likely to present with gastrointestinal symptoms than the patients from the fourth wave. Moreover, patients in the fifth wave had lower arterial oxygen saturation on admission (88% vs. 90%;

P
=
0.026

), lower levels of WBCs (neutrophils and lymphocytes) (6300.00 vs. 8000.00;

P
=
0.004

), and higher percentages of pulmonary involvement in the chest CT scans (50% vs. 40%;

P
<
0.001

). Furthermore, these patients had longer hospital stays than their fourth-wave counterparts (7.00 vs. 5.00;

P
<
0.001

). Conclusions. Our study indicated that patients in the summer COVID-19 wave were more likely to present with gastrointestinal symptoms. They also experienced a more severe disease in terms of peripheral capillary oxygen saturation, percentages of pulmonary involvement in CT scans, and length of hospital stay.
Research on Small Sample Nonlinear Cointegration Test and Modeling Based on the LS‐SVM Optimized by PSO
Authors: Du Jungang
Published: August 2022

According to the definition of nonlinear cointegration, this article studies the small sample nonlinear cointegration test and NECM (Nonlinear Error Correction Model) based on the LS‐SVM (Least Squares Support Vector Machine) optimized by PSO (Particle Swarm Optimization). And the logical process of this method is also designed. Then, we carry out empirical research on the ship maintenance cost index and the several price indexes. Based on the judgment of the type of cointegration test relationship, the test of the nonlinear cointegration test relationship of small samples is realized, and the NECM for predicting the ship maintenance cost index is established as well, which is compared with the VAR model of linear vector. The research result shows that the small sample nonlinear cointegration test and modeling method based on the LS‐SVM Optimized by PSO can describe the nonlinear cointegration test relationship of the small sample system. And the NECM has better performance. The prediction effect can effectively predict small sample nonlinear systems. We also compare the prediction results with the wavelet neural network algorithm, and the results show that the generalization ability of LS‐SVM Optimized by PSO is better, and the prediction accuracy of small samples is higher.
circ_0052184 Promotes Colorectal Cancer Progression via Targeting miR-604/HOXA9 Axis
Authors: Huang Yandong , Bai Qinyang , Wang Zhanlong , Yu Hongbo , Li Yanru , Lu Hao , Kang Huimin , Shi Xuewei , Feng Kai
Published: August 2022

Background. The mortality rate of colorectal cancer (CRC) ranks second. circRNAs are abnormal expression in some diseases, and their dysregulation is associated with cancer progression. Recent studies have shown that the malignant progression of colorectal cancer is inseparable from the abnormal expression of circRNAs. Methods. First, the circ_0052184 expression in clinical tissue and cell samples was analyzed by qRT-PCR. Then, we constructed circ_0052184-silenced CRC cells and detected by qRT-PCR. Furthermore, the proliferation ability of cells was detected by colony formation assay. Cell migration ability was tested by wound healing assay and transwell assay. Cell invasion ability was detected by transwell assay. Results. Expression of circ_0052184 was significantly increased in colorectal cancer cell lines and tissues. Silencing circ_0052184 affected the proliferation, migration, and invasion of colorectal cancer cells. miR-604 was targeted by circ_0052184. The downstream target of miR-604 was HOXA9, and silencing circ_0052184 inhibited HOXA9 expression. The existence of the circ_0052184/miR-604/HOXA9 regulatory network in colorectal cancer was validated. circ_0052184 promoted the occurrence and development of colorectal cancer by targeting the miR-604/HOXA9 axis. Conclusions. Our study revealed that the molecular mechanism of circ_0052184 regulated the miR-604/HOXA9 axis, which might promote the malignant progression of colorectal cancer cells.
Research on Construction Cost Control Technology of Construction Project Based on Big Data Analysis Theory
Authors: Yu Xiaobing , Zuo Hengzhong
Published: August 2022

The current methods proposed in construction cost control of construction projects have problems such as applicability and low accuracy. Therefore, this paper proposes a method for evaluating engineering cost control based on the big data Analytic Hierarchy Process (AHP) method. Based on the big data technology, the construction cost control index of the construction project is selected, and the construction cost control index model of the construction project is constructed according to the selection results, and the evaluation set is constructed. The corresponding weights of the construction cost control indicators of each construction project are obtained through the analytic hierarchy process, and a weight set is constructed. The membership relationship between the index set and the evaluation set is determined, a fuzzy relationship matrix is constructed, and the construction cost control result of the construction project is obtained according to the calculated weight and the constructed fuzzy relationship matrix. The test results of examples show that the risk assessment accuracy of the proposed method is higher than that of ordinary methods, and the quantitative processing of audit risk assessment is realized.
Efficacy of Trastuzumab + Cisplatin Combined with Irinotecan on the Quality of Life of Patients with Advanced Her-2 Positive Gastric Cancer
Authors: Yang Yu-Xin , Li Chun-Ying , Yin Wen-Jie , Chen Xia
Published: August 2022

Objective. To observe the effect of trastuzumab and cisplatin combined with irinotecan in the treatment of advanced Her-2 positive gastric cancer and its influence on disease control rate. Methods. From January 2018 to January 2021, 120 patients with advanced Her-2 positive gastric cancer admitted to our hospital were selected as the research subjects. According to the treatment plan of the patients, they were divided into a control group and a joint group, with 60 cases in each group; the control group was given trastuzumab + cisplatin, the joint group was treated with irinotecan on this basis, and the clinical effects and disease control rate of the two groups were observed. Results. After treatment, there were 4 patients with CR in the joint group and 0 patients with CR in the control group. The ORR and DCR of the joint group were significantly higher than those of the control group (

P
<
0.05

). The expression levels of CA199, CEA, and CA724 after treatment in the two groups were significantly reduced (

P
<
0.05

), and the reduction in the joint group after treatment was more evident as compared with the control group (

P
<
0.05

). The joint group witnessed better memory function, physical function, behavioral function, emotional function, and communication function than the control group (

P
<
0.05

), and the scores of all dimensions of the two groups of patients after treatment were superior to those before treatment (

P
<
0.05

). The occurrence of side effects was not statistically different between the two groups of patients (

P
>
0.05

). The 1-year survival rate of the control group was 41.67%, the PFS was 6.33 ± 1.02 months, and the OS was 15.51 ± 2.16 months; the 1-year survival rate of the joint group was 43.33%, and the PFS was 8.05 ± 1.07 months, and OS was 16.03 ± 2.44 months; there was no significant difference in the 1-year survival rate between the two groups (

P
>
0.05

), the difference in PFS between the groups was significant (t = 9.013,

P
<
0.001

), and the difference in OS between the groups was not significant (t = 1.236,

P
=
0.219

). Conclusion. Trastuzumab + cisplatin combined with irinotecan yields a promising result in the treatment of advanced gastric cancer. It can effectively regulate the expression level of tumor markers, delay disease progression, and improve the quality of life of patients. Moreover, irinotecan will not bring more toxic side effects.