bluuebunny/crossref_metadata_2025 huggingface dataset:
100 YEARS TO FIRST ALL-RUSSIAN MEETING OF ZOOLOGISTS, ANATOMISTS AND HISTOLOGIST AND MODERN HUMAN ANATOMY
Authors: Khayrullin Radik М.
Published: January 2023

The content of the article is a verbatim report of the speech under Title «100 years of Russian anatomy (on the anniversary of the founding of the Scientific Society of Anatomists)», included in the scientific program of the All-Russian Scientific and Practical Conference with international participation «Morphological Aspects in Practical Medicine and Biology», dedicated to the 65th Anniversary of the Department of Human Anatomy of the Medical Institute of the Ammosov North-Eastern Federal University as part of the annual XIII National Congress with international participation «Ecology and Human Health in the North», which took place in Yakutsk City (Russia, Sakha Republic) on December 8, 2022. The congress was also dedicated to the 100th Anniversary of the formation of the former Yakut Soviet Socialist Republic of USSR and the 65th Anniversary of medical education in Yakut Republic. In the report dedicated to the Anniversary of the founding of the first professional scientific community of anatomists, histologists and embryologists in the history of the Russian state - the All-Union Society of Zoologists, Anatomists and Histologists (later - the All-Union Scientific Society of Anatomists, Histologists and Embryologists - AUSSAHE), which took place from December 15 to 21 1922 in Petrograd (later - Leningrad and renamed Saint-Petersburg) provides information about the initiators of the convocation of the meeting, its preparation and conduct, the content of the work and key reports of anatomists presented at the meeting. The meeting was initiated by a prominent Russian zoologist, specialist in animal morphology, Doctor of Zoology, Professor, Academician of the Russian Academy of Sciences, Rector of Petrograd State University Vladimir Shimkevich, as well as the famous Russian Histologist, Professor Alexander Dogiel - the Founder of the Russian scientific journal «Archive of Anatomy, Histology and Embryology», Professors Vladimir Tonkov, Konstantin Deryugin, Nikolay Koltsov and others. Founded in 1922 at the I All-Russian meeting, the All-Russian Society of Zoologists, Anatomists and Histologists was at its IV All-Union meeting in 1930 renamed into the All-Union Scientific Society of Anatomists, Histologists and Zoologists, and then, at the V meeting in 1949 - into the All-Union scientific society of anatomists, histologists and embryologists or AUSMSAHE. AUSMSAHE in September 1991 at its last XI meeting in Minsk ceased to exist.The author noted the anatomical reports of the meeting, which laid the foundation for the entire subsequent development of Russian anatomy as a science and the problems of its current state.
A Pedagogy of Slow: Integrating Experiences of Physical and Virtual Gallery Spaces to Foster Critical Engagement in SoTL
Authors: Supple Briony , Cronin James G. R.
Published: January 2023

This article makes a case for SoTL practitioners to engage in what we term a pedagogy of slow. Here, “slow” connotes with waiting and patience. It takes time to learn and acquire the skills that a SoTL scholar needs. “Doing SoTL” we therefore argue, requires a pedagogy that takes time and sees time as an ally instead of as an opponent. In what the university has become, there seems little room for a pedagogy of slow that both offers and allows for time. In this article we present a case for considering engagement with the visual arts as part of a pedagogy of slow and the development of SoTL. By making the familiar strange, we acknowledge the implications of visual thinking strategies for social engagement by highlighting teaching and learning as relational. Working with colleagues in the context of continuing professional development, we collected data via focus groups and written reflections within physical and virtual gallery spaces to glean insight into participant experiences of slow looking as the antithesis to fast-paced and pressurised environments. We highlight how learning to become a SoTL scholar is an iterative process that requires time and generates what we term “productive friction.” This is the iterative process which creates dislocation and uncertainty within participants, but which also has the capacity to nudge towards a transformation of the professional self.
Theories of European Integration in Searching for Explanation of Disintegration
Authors: Moiseeva D.
Published: January 2023

In this article, four classical theories of European integration (realism, neofunctionalism, federalism and liberal intergovernmentalism) are revised in order to figure out their understanding of disintegration, its causes and possible outcomes. Up until recently, disintegration has been of little concern to European studies. Nonetheless, each of the theories is capable of contributing to explaining the disintegration process, all together they give a proper theoretical starting point for further conceptualization of the phenomenon. The article makes it evident that different theories have their own visions of reasons for creating supranational regimes, just like they view possible causes of these regimes’ downfall and transformation. Structural realism is finding the reasons for both integration and disintegration in the concepts of security, balance of power and outer threats. Federalism, on the contrary, focuses on internal political dynamics between member states and emphasizes common interests and values, ideology, economic inequality, cultural and linguistic homogeneity. Federalism explains possible EU disintegration through EU malfunctioning as a political system. Both aforementioned theories are limited by being state-centered, which cannot be said about neofunctionalism. Neofunctionalists imagine disintegration as a multi-level and multi-directional process that does not necessarily mean coming back to full national sovereignty. Finally, liberal intergovernmentalist approach views disintegration as a redistribution of power that cannot make a return to status quo ante. Each theory can provide us with its own insight on disintegration but can’t provide an overwhelming explanation. Nevertheless, further theorizing with classical theories as a starting point is yet to be done.
Romania’s Interests in South-Eastern Europe and Cooperation with Turkey
Authors: Bitkova T.
Published: January 2023

The article deals with Romania’s foreign policy vectors in South-Eastern Europe regarding its membership in NATO and in the European Union. It is noted that the main foreign policy vector of Bucharest in the region is an alignment with the Republic of Moldova and a prospect of these two states uniting. The role of Romania is presented in a platform for negotiations which is the South-Eastern European Cooperation Process (SEECP), in the Three Seas Initiative, the Bucharest Nine Initiative and in the Romania –Poland– Turkey trilateral dialogue. The place of the Black Sea region in ambitions of the Romanian leadership and its significance in a strategic partnership between Romania and the Republic of Turkey are revealed. The author notes that the Balkans are not a priority vector of Romanian foreign policy, but the Western Balkan states are always present in Bucharest’s objects of attention, since here, as well as in the Black Sea region, global players are present, including Russia, a country Romania’s relations with has been in a critical condition for many years. In regards to the Romania’s relations with the Western Balkan countries, cooperation between Romania and Serbia stands out. Despite the pressure from Brussels, Romania supports Serbia in not wanting to tolerate the self-declared independence of Kosovo. Different approaches to policies of the Russian Federation are the reason behind the inconsistencies in the Romanian-Serbian relations. Romania does not possess enough recourses to lead an independent activity in the Balkans region and it mainly integrates in the policy of the European Union and the USA. Turkey pursues a policy of increasing its influence in the Balkans, with the cultural strategy of reconstruction of the Turkic world being one of the evident manifestations of the policy. The Romanian leadership abstains from any comment on this topic. Having not the same weight in world politics, Romania and Turkey на декларативном уровне demonstrate complete trust in one another and mutual understanding on a declarative level, but, according to the analysis of foreign policy platforms and partners’ particular political acts, their relations develop in the context of varying and sometimes even opposite approaches to a list of crucial international events.
The Problem of the UK Energy Security Before the Referendum on Brexit
Authors: Andreeva T.
Published: January 2023

The article is devoted to the problem of ensuring the UK energy security since the 90s of the 20th century to the date (June 23, 2016) of referendum on the UK exit from the European Union (Brexit). The problem is considered in its evolution: from the moment of its emergence during the conservative government of John Major, via the attempts to define the different aspects of the problem and to outline ways to solve it by labour cabinets of Tony Blair (1997–2007) and Gordon Brown (2007–2010), and up to formulating the notion of ‘energy security’ and making concrete steps to strengthen the UK energy security during David Cameron – Nick Clegg coalition cabinet (2010–2015) and the conservative cabinet of David Cameron (2015–2016). The problem is scrutinized with the help of vast number of the official documents and White Papers on energy policy of British governments, the UK Ministry of Energy and Climate Change and the Foreign Office. The article shows that the problem of reducing greenhouse gases emissions as an important part of the international efforts for containment of global climate changes is one of the main challenges for the UK energy security and the key driving force behind diversification of the British energy sector. The author considers the rising dependence of the UK economic development, the prosperity of British consumers and industry on the guaranteed, affordable, secure supply of fossil fuels from the unstable countries of the world as the second important challenge in strengthening the UK energy security. The transition of the United Kingdom’s energy balance towards rapid implementation of the low-carbon technologies (the nuclear power and the renewable energy sources [RES]) is seen in the article as the way to meet two above-mentioned challenges and to strengthen the UK energy security.
REB’s Statistical Series: Surveys of Industrial Enterprises
Authors: Aukutsionek S. , Batyaeva A. , Dyomina N. , Egorov A. , Matveev A.
Published: January 2023

Industrial indexes of the Russian Economic Barometer cover a wide range of economic indicators of Russia’s industrial enterprises. The article presents the basic statistical data collected on a monthly, quarterly and semi-annual base by the Russian Economic Barometer through direct surveys of industrial enterprises’ managers. Regular extension of rows allows to consider the dynamics of more than 100 series of indicators, to conduct a comparative analysis of data collected since 1991.
Design of Non-Tactical Deployable 20 Gwh (17.20841 Kilo Ton TNT) Fusion Device - Energy Basis
Authors: Rafique Muhammad Musaddique Ali
Published: January 2023

Fusion device and its structure may be designed by various means. Two of most popular are; weight basis (described in previous study by author) and energy basis. In present research, later method is explored and described. Energy basis is based on amount of energy released from device upon detonation followed by explosion. Its beneficial in a sense that device size can be kept as independent variable as compared to dependent in former case. Further, it shortens the design procedure. For example, heat transfer pattern in such approach directly helps in quantifying wall thickness which dictates material, fabrication, and manufacturing route. It may also eliminate anisotropy as wall thickness is direct function of amount of heat at which it will rupture and can be much thinner. Device geometry can also be flexibility controlled as it is no longer dependent on pay load bay capacity. This allows more freedom in designing subsystems (compartments, their locations, focusing, switches, and mixers). Such devices can be more compact and simpler. Few such design configurations are proposed.
Neutrosophic Failed SuperHyperStable as the Survivors on the Cancer's Neutrosophic Recognition Based on Uncertainty to All Modes in Neutrosophic SuperHyperGraphs
Authors: Garrett Henry
Published: January 2023

In this research, Assume a neutrosophic SuperHyperGraph. Then a ``Failed SuperHyperStable $\mathcal{I}(NSHG)$ for a SuperHyperGraph $NSHG:(V,E)$ is the maximum cardinality of a SuperHyperSet $S$ of SuperHyperVertices such that there's a SuperHyperVertex to have a SuperHyperEdge in common; a ``neutrosophic Failed SuperHyperStable'' $\mathcal{I}_n(NSHG)$ for a neutrosophic SuperHyperGraph $NSHG:(V,E)$ is the maximum neutrosophic cardinality of a neutrosophic SuperHyperSet $S$ of neutrosophic SuperHyperVertices such that there's a neutrosophic SuperHyperVertex to have a neutrosophic SuperHyperEdge in common. Assume a SuperHyperGraph. Then an ``$\delta-$Failed SuperHyperStable'' is a \underline{maximal} Failed SuperHyperStable of SuperHyperVertices with \underline{maximum} cardinality such that either of the following expressions hold for the (neutrosophic) cardinalities of SuperHyperNeighbors of $s\in S:$ $~|S\cap N(s)| > |S\cap (V\setminus N(s))|+\delta,~|S\cap N(s)| < |S\cap (V\setminus N(s))|+\delta.$ The first Expression, holds if $S$ is an ``$\delta-$SuperHyperOffensive''. And the second Expression, holds if $S$ is an ``$\delta-$SuperHyperDefensive''; a``neutrosophic $\delta-$Failed SuperHyperStable'' is a \underline{maximal} neutrosophic Failed SuperHyperStable of SuperHyperVertices with \underline{maximum} neutrosophic cardinality such that either of the following expressions hold for the neutrosophic cardinalities of SuperHyperNeighbors of $s\in S:$ $~|S\cap N(s)|_{neutrosophic} > |S\cap (V\setminus N(s))|_{neutrosophic}+\delta,~ |S\cap N(s)|_{neutrosophic} < |S\cap (V\setminus N(s))|_{neutrosophic}+\delta.$ The first Expression, holds if $S$ is a ``neutrosophic $\delta-$SuperHyperOffensive''. And the second Expression, holds if $S$ is a ``neutrosophic $\delta-$SuperHyperDefensive''. A basic familiarity with Extreme Failed SuperHyperClique theory, Neutrosophic Failed SuperHyperClique theory, and (Neutrosophic) SuperHyperGraphs theory are proposed.
Topography, Slope and Geomorphology’s Influences on Shoreline Dynamics along Dakar’s Southern Coast, Senegal
Authors: Pouye Ibrahima , Adjoussi Dieudonné Pessièzoum , Ndione Jacques André , Sall Amadou
Published: January 2023

Among the impacts of climate change in West Africa, coastal erosion is the most threatening disaster apart from floods and the increase in temperature. The southern coast of the Dakar region, as part of the most threatened coastal zones in West Africa, records the most current coastal damages in Dakar due to its coastline dynamics and low-lying area. This study was conducted in three littoral cells (Mbao, Bargny and Toubab Dialaw) and aims to investigate if there is a relationship between the coastline dynamic, topographic and slope and the contribution of the geomorphology along the southern coast of Dakar. It helps to understand better the role which plays the topography, Slope and geomorphology in coastal dynamics using remote sensing, cartographic tools and statistical methods. The Modified Normalized Different Water index (MNDWI) was employed to delineate the coastlines before computing the dynamic rate of the coastline using the Digital Shoreline Analysis System (DSAS) software. After that, Topography and Slope were determined using Digital Elevation Model (DEM). Then, the correlation between the coastline dynamic, topography and slope was analyzed through the coefficient of correlation and multiple linear regression model. High dynamic rates were noted in the littoral cells, where the topography and slope are low. In Mbao, there is a significant relationship between the coastline dynamic, topography and slope with a coefficient of correlation of about 0.63. In Bargny, the relationship is also significant, with a coefficient of 0.87. The relationship is not significant in Toubab Dialaw, where topography and Slope are high, with a coefficient of 0.15. We conclude that topography, slope and soil properties play an important role in the study area.
Temozolomide, Simvastatin and Acetylshikonin Combination Induces Mitochondrial Dependent Apoptosis in GBM Cells which is Regulated by Autophagy
Authors: Hajiahmadi Sima , Lorzadeh Shahrokh , Iranpour Rosa , Karima Saeed , Rajabibazl Masoumeh , Shahsavari Zahra , Ghavami Saeid
Published: January 2023

Glioblastoma multiforme (GBM) is one of the deadliest cancers. Temozolomide (TMZ) is the most common chemotherapy used for GBM patients. Recently, combination chemotherapy strategies have more effective antitumor effects and focus on slowing down the development of chemotherapy resistance. A combination of TMZ and cholesterol lowering medications (statins) is currently under investigation in in vivo and clinical trials. In our current investigation, we have used a triple combination therapy of TMZ, Simvastatin (Simva), and Acetylshikonin (ASH) and investigated its apoptotic mechanism in GBM cell lines (U87 and U251). We used viability, apoptosis, reactive oxygen species (ROS), mitochondrial membrane potential (MMP), caspase-3/-7, acridine orange (AO) and immunoblotting autophagy assays. Our results showed that TMZ/Simva/ASH combination therapy significantly induced more apoptosis compared to TMZ, Simva, ASH, and TMZ/Simva treatments in GBM cells. Apoptosis via TMZ/Simva/ASH treatment induced mitochondrial damage (increase of ROS, decrease of MMP) and induced caspase-3/7 activation in both GBM cell lines. Compared to all single treatments and the TMZ/Simva treatment, TMZ/Simva/ASH significantly increased positive acidic vacuole organelles. We further confirmed that the increase of AVOs during the TMZ/Simva/ASH treatment was due to partial inhibition of autophagy flux (accumulation of LC3β-II and decrease in p62 degradation) in GBM cells. Our investigation also showed that TMZ/Simva/ASH-induced cell death was depended on autophagy flux as further inhibition of autophagy flux increased TMZ/Simva/ASH-induced cell death in GBM cells. Finally, our results showed that TMZ/Simva/ASH treatment potentially depends on an increase of Bax expression in GBM cells. Our current investigation might open new avenues for more effective treatment of GBM but further investigations are required for better identification of the mechanisms.
Spread of the Optical Power Emission of Several Units of the Same Laser Therapy Devices Used in Sports Medicine, Which Cannot Be Assessed by the Users, Shown by Means of High-Fidelity Laser Measurement Technology
Authors: Kaub Leon , Schmitz Christoph
Published: January 2023

Laser therapy devices (LTDs) operating with near-infrared laser light are increasingly being used in sports medicine. For several reasons the users cannot evaluate whether or not such devices emit laser beams according to the specifications provided by the manufacturer and the settings of the device. In this study the laser beams from two different LTDs that can be used in sports medicine were thoroughly characterized by measuring the emitted power, pulse shapes and lengths, and spatial intensity distributions using professional, high-fidelity laser measurement technology. This was repeated for three units of each LDT independently to distinguish problems of individual units from potential intrinsic instrument design errors. The laser beams from the units of one LTD agreed with the settings at the device, with the measured average power for these units being within 3.3% of the set power. In contrast, the laser beams from the units of the other LTD showed large deviations between the settings and the actual emitted light. This device came with three laser diodes that could be used independently and simultaneously. The average power differed greatly between the units as well as between the laser diodes within each unit. Some laser diodes emitted essentially no light, which could lead to a lack of treatment of patients. Other laser diodes emitted much more power than set at the device (up to 230%) that could result in skin irritations or burnings of patients. These findings indicate a need for better standardization and consistency of therapeutic laser light sources.
From Struggles to Success: Investigating the Impact of Early Learning Assessments on Students Performance and Motivation
Authors: Boyle Christopher , Hashemi Nicole
Published: January 2023

In this paper, we have investigated the impact of an early learning assessment on students' motivation for improving their performance throughout the semester. An observation analysis was conducted on an entry level mechanical engineering course in which students are enrolled in during their first semester of engineering work. This study analyzes the effect that a first exam, with an average below a passing grade, has on student's outcome in the course. It was hypothesized that students were motivated to achieve their desired grade outcomes following inadequate performance on the first exam. This was investigated by diving into the results of the course and referencing initial performance to the remaining exam and assessment outcomes. Students were placed into grade bands ranging from 0 to 100 in 20% increments. Their results were tracked and it was shown that for the second mechanics exam, averages jumped 43.333%, 35.35%, and 30.055% for grade bands of 0 to 20, 20 to 40, and 40 to 60 respectively. Assessment grades increased as well with the remaining assessments being averaged to a score of 91.095%. Variables contributing to student performance came from both with-in and outside the classroom. Learning communities, material differentiation, and student and professor adaptation all contributed to the rise in performance. It was concluded that the internal and external variables acted in combination with one another to increase student dedication to achieve success.
Distribution of Selenium Fractions and Species in the Rock-Soil-Plant Interface of Maize (Zea mays L.) From Naore Valley Selenosis Region
Authors: Pinzon-Nuñez Diego Armando , Wiche Oliver , Bao Zhengyu , Xie Shuyun , Fan Bolu , Tang Molan , Tian Huan
Published: January 2023

Maize (Zea mays) is one of the most important staple food and primary source of livestock feed in the world. As the consumption of maize grown on the selenium-enriched soils of Naore Valley is one of the apparent causes of selenosis in the area, this work collected and analyzed total Se, Se fractions, and Se species distributions in maize plant samples, including grains, leaves, stalks, roots, rhizosphere soils, and the most representative parent rock materials from Naore Valley, Ziyang County, China. The Se distribution in soils markedly correlated with the weathered Se-enriched bedrocks, but most of the Se in the analyzed soils is enclosed as recalcitrant residual Se and organic-sulfide bound Se. In contrast, Se in rocks had a comparatively higher bioavailability and is bounded mainly to organic matter and sulfides minerals, with very few of the Se enclosed in the residual fraction. Maize plants might take a large amount of Se from the organic-sulfide bound Se fraction in the Se-rich soils, the weathered products from bedrocks or plant litters. Total Se concentrations in the collected samples were observed in descending order soil>leaf>root>grain>stalk. The predominant Se species detected in maize plants was SeMet. Se inorganic forms, mainly Se(VI), decreased from root to grain and were possibly assimilated into organic forms. Se (IV) was barely present. The natural increases in Se concentration affected mainly leaf and root dry-weight biomass as they are the organs that coped with the highest Se accumulation. This paper offers an insight into the uptake, accumulation, and distribution of Se forms in natural Se-rich maize crops and an opportunity for shifting Se-rich soils from menaces to valuable resources for growing Se-rich agricultural products.
Laparoscopic metroplasty for uterine scar defect after cesarean section
Authors:   Lomonosov Moscow State University, Moscow, Russian Federation, Panina O.B. , Balashova Kh.B. ,   Lomonosov Moscow State University, Moscow, Russian Federation, Shcherbakova L.N. ,   Lomonosov Moscow State University, Moscow, Russian Federation, Bugerenko A.E. ,   Lomonosov Moscow State University, Moscow, Russian Federation
Published: January 2023

The number of births among patients with uterine scar defect after cesarean section is increasing worldwide. To reduce complications during pregnancy, these patients undergo surgical correction of uterine scar defect – metroplasty, which is performed in the preconception period by laparotomy, laparoscopy, and the vaginal route. Objective. To analyze the literature on the effectiveness of metroplasty for uterine scar defect after cesarean section. Conclusion. It is necessary to search for new cellular products that can initiate and sustain differentiation of myofibroblasts, block the processes of their apoptosis, which will contribute to uterine wound healing without scar formation. Key words: cesarean section, laparoscopy, metroplasty, uterine scar defect, uterine scar
Evaluation of the efficacy of different treatment modalities for chronic atrophic endometritis
Authors:   Bashkir State Medical University, Ufa, Russian Federation, Gazizova G.Kh. , Yashchuk A.G. ,   Bashkir State Medical University, Ufa, Russian Federation, Maslennikov A.V. ,   Bashkir State Medical University, Ufa, Russian Federation, Dautova L.A. ,   Bashkir State Medical University, Ufa, Russian Federation, Battalova G.Yu. ,   Bashkir State Medical University, Ufa, Russian Federation
Published: January 2023

Objective. To study the efficacy of different treatment regimens in patients with chronic atrophic endometritis against the background of endometrial hemodynamic dysfunction using intrauterine perfusion of platelet-rich plasma (PRP therapy) or sulodexide, or a combination of PRP therapy and sulodexide. Patients and methods. This study included 116 patients with morphologically confirmed diagnosis of chronic endometritis. Patients were divided into three groups: group 1 (n = 18) received PRP therapy in addition to basic therapy; group 2 (n = 68) received basic therapy and sulodexide; group 3 (n = 3) received PRP therapy combined with sulodexide. All patients underwent Doppler ultrasonography on day 7 (±1) after ovulation and endometrial pipelle biopsy with further histological and immunohistochemical examination (VEGF, TGF-β, CD138) before and after treatment. Results. After treatment, histological examination revealed significant changes in the morphological pattern of the endometrium in all patient groups. However, the best results were observed in group 3: inflammatory infiltrates and stromal fibrosis persisted in 23.3% of patients, stromal sclerosis – in 20% of patients, plasma cells – in 10% of patients. Assessment of changes in TGF-β expression in the endometrial epithelium and stroma revealed its decrease in all groups, but the maximum decrease was noted in group 3. Conclusion. The most effective treatment method for chronic atrophic endometritis is the combined use of PRP therapy and sulodexide. Key words: chronic endometritis, intrauterine hemodynamics, sulodexide, PRP therapy
Pharmacotherapy for pregnant women with arterial hypertension considering pathogenetic factors during the SARS-CoV-2 pandemic
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Konyshko N.A. , Morozova T.E. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Konyshko A.S. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: January 2023

Objective. To analyze and present current scientific data and the results of our own research on the features of pharmacotherapy for pregnant women with arterial hypertension (AH) under present conditions. Materials and methods. A comprehensive analysis of the available up-to-date scientific sources over the past decade was carried out in the Scopus, PubMed.com, and E-library databases. Physicians (n = 100) and pregnant women with AH (n = 164) were interviewed about the use of antihypertensive agents between 2009 and 2021. Conclusions. The general principles of pharmacotherapy for AH in pregnant women include: maximum efficacy for the mother; fetal safety; therapy according to blood pressure (BP) levels, maternal and fetal risk factors; initiation of treatment with minimal doses of one drug; switching to another class of drugs and combination therapy when the first-line drugs are not effective or poorly tolerated; preference to dynamic, remote and “hard” control of hemodynamic parameters aimed at target systolic BP of 140 mm Hg and diastolic BP of 85 mm Hg. The antihypertensives of choice with proven efficacy and safety in the gestational period are a centrally acting α-adrenoceptor agonist α-methyldopa, a calcium channel blocker nifedipine, and beta-blockers. All interviewed specialists in the Central Federal District are sufficiently competent and informed about the pharmacological control of AH in pregnant women. Key words: pregnant women, arterial hypertension, SARS-CoV-2, antihypertensive agents
Improving the effectiveness of therapy for chronic endometritis
Authors:   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Dobrokhotova Yu.E. , Borovkova E.I. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Zaydieva Z.S. ,   City Clinical Hospital No 40, Moscow, Russian Federation, Romanovskaya V.V. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Nugumanova O.R. ,   City Clinical Hospital No 40, Moscow, Russian Federation
Published: January 2023

Objective. To study the effectiveness of combination therapy for chronic endometritis using standard antibiotic treatment regimen and immunomodulators (exogenous cytokine therapy). Patients and methods. This prospective randomized clinical trial enrolled 40 patients with a histologically verified diagnosis of chronic endometritis. Patients were randomized into two groups; the study group (n = 20) received combination therapy (antibiotics + Superlymph 25 units), and the control group (n = 20) received monotherapy with antibiotics. The course of antibiotic therapy included a 10-day use of ofloxacin 400 mg twice daily with metronidazole 500 mg twice daily. General methods of clinical investigation, histological and immunohistochemical examinations, and statistical measures of variation were used. Results. Mild endometritis was diagnosed in 30% (6/20) of patients in the study group and in 25% (5/20) of patients (p = 0.363) in the control group, moderate endometritis – in 45% (9/20) and 55% (11/20) (p = 0.264), and severe endometritis – in 25% (5/20) and 20% (4/20) (p = 0.351), respectively. After the end of therapy, the control histological and immunohistochemical examinations showed positive dynamics in both groups. The signs of chronic endometritis were absent in 90% (18/20) of patients in the study group and in 70% (14/20) of patients in the control group (p = 0.05). In the study group, two patients had signs of mild (1/20, 5%) and moderate (1/20, 5%) endometritis. In the control group, histologically mild endometritis persisted in 20% (4/20) of patients and moderate endometritis – in 10% (2/20) of patients (in comparison with the study group, p ≤ 0.05). In six months after the end of therapy, pregnancy occurred in 45% of patients in the study group, of which 22.2% were the result of using assisted reproductive technologies (ART) and 77.8% – spontaneous pregnancy. In the control group, pregnancy occurred in 25% of patients, and in 20% it was achieved by ART. In one patient, pregnancy was terminated at 12 weeks due to fetal malformations. Conclusion. Combination therapy demonstrated higher rates of recovery and pregnancy. The overall efficacy of therapy was significantly higher in the study group (p ≤ 0.05). Key words: chronic endometritis, exogenous cytokine therapy, Superlymph, antibiotics, infertility
EXPERIMENTAL STUDY OF ELEMENTARY ACTS OF HYDRODYNAMICS AND HEAT TRANSFER DURING THE INTERACTION BETWEEN WATER DROPS AND FILM AND CASTING ROLLER SURFACE
Authors: Pereselkov A. , Kruglyakova O.
Published: January 2023

Experimental studies of the boundary conditions of heat transfer for the thermally stressed state of casting rollers while are spraying with flat-jet nozzles in a thermal preconditioning unit have been carried out.

It is shown that the hydrodynamic conditions on the sprinkling surface are formed as a result of both the influx of "primary" dispersed water from the flat jet nozzle, and the "secondary" liquid coming from neighboring areas in the form of reflected drops and films.

The heat transfer effecting individual factors that form the hydrodynamic conditions on the sprinkling surface was studied separately.

The heat transfer intensity was studied depending on the spraying density, the injection-pressure drop and the temperature of the cooled surface when the "primary" drop flow runs in the heat exchange surface. The local sprinkling density of droplets on the surface under the flat-jet nozzle spray were measured using a sampling tube moved by a coordinator. At the same time, the ingress of “secondary” liquid into it was excluded.

The specific heat flux and heat transfer coefficient were determined using a heat meter made of a nichrome tape heated by direct current. In this case, the isothermality of the surface of the measuring section was ensured. Thermocouples measured the temperature of the lower surface of the tape, and then the stationary temperature of the upper surface of the heat meter sprinkled with drops is calculated.

As a result of the multivariate analysis of the experimental data, the correlation dependence of the heat transfer coefficient in dependance on the local spraying conditions of the heat meter surface was obtained.

Also, studies of the heat transfer during water film flow over the heat meter surface were carried out. A similar situation takes place when water spreads between the adjacent nozzles sprinkling zones of the roller surface.

The correlation dependence between the heat transfer coefficient, the water film speed and the cooled surface temperature was obtained.

Studies of heat transfer during combined influence of moving water film and a flat-jet nozzle drop flow on the heat exchange surface showed that the heat transfer rate is approximately 80–90 % of the arithmetic sum of the coefficients obtained by separate cooling the heat meter with drops and a water film.
RESEARCH OF HYBRID ENVIRONMENTALLY SAFE BIODEGRADABLE COMPOSITES BASED ON POLYLACTIDE, COFFEE GROUNDS AND HUMІС SUBSTANCES
Authors: Lebedev V. , Miroshnichenko D. , Tykhomyrova T. , Savchenko D. , Mazchenko M. , Mysiak V. , Kochetov M. , Solovey L.
Published: January 2023

In the article, a study was conducted with the aim of establishing the characteristics of hybrid ecologically safe biodegradable filled composites based on polylactide, coffee grounds and humic substances. Hybrid ecologically safe biodegradable filled composites were obtained by extruding pre-prepared polylactide, coffee grounds and humic substances in a single-screw laboratory extruder at a temperature of 170–200 °C and a roll rotation speed of 30–100 rpm. When obtaining hybrid ecologically safe biodegradable filled composites, lactic acid polylactide polymer of the extrusion brand Terramac TP-4000 was used. Waste coffee grounds collected in 8 different coffee shops in the city of Kharkiv and dried to a moisture content of 0,5 % were used. Humic substances were used as hybrid modifiers. It was established that the hybrid modification of highly filled polylactide-coffee grounds systems with humic derivatives of lignite in the form of humic substances allows to significantly increase the main strength characteristics. It was established that there is a 2.5-fold increase in impact toughness and destructive bending stress during hybrid modification of environmentally safe biodegradable filled composites based on polylactide, coffee grounds, and humic substances, while the optimum from the point of view of strength characteristics is the content of coffee grounds at the level of 50 % by weight and 0.5 % wt. humic substances. For such hybrid ecologically safe biodegradable filled composites based on polylactide, coffee grounds and humic substances, the melting flow rate is characteristic at the level of 3.1 g/10 min. and the processing temperature range is 182–188 °С. It was also established that hybrid modification in the framework of obtaining hybrid ecologically safe biodegradable filled composites based on polylactide, coffee grounds and humic substances with a content of 0.5 % by mass. different types of humic substances in them and different contents of coffee grounds allow them to preserve biodegradation properties for 6 months.
CHARACTERISTICS OF TRITICUM AESTIUM RESISTANCE GENES TO DISEASE CAUSES AND ANALYSIS OF BIOTECHNOLOGICAL PREPARATIONS
Authors: Chupryna Yu. , Bliznjuk O. , Masalitina N. , Belinska A.
Published: January 2023

The dominance of resistance of host plants and the recessive virulence of parasites are the result of their co-evolution with the host, which is the main partner. However, mutant resistance genes are usually recessive. Distant hybridization is needed to replenish the resistance gene pool. The larger the area planted with a resistant variety, the more sensitive it becomes. Resistance genes are reduced during reproduction. The genes currently used for resistance to leaf rust, stem rust, yellow rust and powdery mildew are all from wheatgrass, rye, heliops etc. The search for ecologically safe and effective means of preserving crops of valuable productive crops led to the formation of alternative protective methods. Among them is the use of biological preparations, the basis of which is the principle of antagonism between different types of microorganisms or the manifestation of their antibiotic activity, in particular, the release of substances toxic to competing organisms into the external environment. The biological method of plant protection is based on a systemic approach, the integrated implementation of two main directions: the preservation and promotion of the activity of natural populations of useful species (entomophages, microorganisms), the self-protection of cultivated plants in agrobiocenoses and the renewal of agrobiocenoses with useful species that are lacking in them or those that are absent.

The fundamental difference between the biological method of plant protection and any other is the use of the first direction, which is carried out using biological preparations, methods of seasonal colonization, introduction and acclimatization of zoophages and microorganisms. The reproduction and efficiency of the activity of beneficial species are facilitated by agrobiotechnical measures and some methods of soil cultivation with the help of which it is possible to create favourable conditions for the life of zoophages. An important agrotechnical measure is the cultivation of varieties of cultural plants resistant to harmful organisms, which contributes to the formation of weakly viable populations of pests.

The collection samples of spring wheat of different ecological and geographical origin were analyzed by pest resistance genes and ecologically stable populations were identified according to their complex and individual resistance to changing environmental climatic conditions. Biological preparations for combating pathogens are characterized.
ANALYTICAL HYPOTHESIS TO SUBSTANTIATE THE FUNDAMENTAL POSSIBILITY OF REGENERATION OF NITROCELLULOSE POWDERS AFTER LONG-TERM STORAGE WITH HYDROGEN PEROXIDE
Authors: Anipko O. , Baulin D.
Published: January 2023

The experience of storing ammunition shows that during long-term storage, pyroxylin powders used in ammunition are capable of arbitrarily undergoing various physical and chemical transformations, which negatively affects the ballistic characteristics of ammunition. The lack of ammunition production in Ukraine has led to the fact that ammunition is currently in operation, the storage time of which reaches 30–35 years or more.

This article analyzes publications devoted to scientific research related to the problems of ballistic stability of gunpowders.

A number of factors affecting the physicochemical stability of powder charges during their long-term operation are given.

Summarizing data on the change in the main ballistic characteristics of ammunition at different periods of their storage are given.

The analysis of chemical processes occurring in nitrocellulose gunpowder during long periods of operation is carried out, and the possibility of carrying out the regeneration of NCP by treatment with hydrogen peroxide is substantiated.

It is assumed that one of the ways to improve the ballistic and energy characteristics of long-term ammunition can be the regeneration of nitrocellulose powder charges. It is shown that at present there are no methods for the regeneration of powder charges with long service life. However, there are encouraging data on the treatment of powders with hydrogen peroxide, on the basis of which a technology for the complete or partial restoration of the ballistic and energy characteristics of a powder charge can be developed.

It is shown that during the regeneration of nitrocellulose powder charges with hydrogen peroxide, the calorific value of the starting material increases. It is important to note that not all of the increase in mass after NCP treatment with hydrogen peroxide can be used to compensate for the lost calorific value, however, in this case, the treatment of NCP with hydrogen peroxide should be considered an effective method for regenerating nitrocellulose powders.
USING THE GREEN – RVACHEV’S QUASIFUNCTIONS METHOD IN THE NUMERICAL ANALYSIS OF ONE ELECTROSTATIC NANOELECTROMECHANICAL SYSTEM
Authors: Konchakovska Oksana
Published: January 2023

The problem of numerical analysis of one electrostatic nanoelectromechanical system is considered in the article. Nanoelectromechanical systems are miniature devices that combine electronic and mechanical components of micro and nano sizes. Electrostatic actuation of the mechanical components of such systems is one of the most common types of actuation and that used in accelerometers, switches, micro-mirrors, micro-resonators, etc. The disadvantages of such devices are related to the pull-in instability. This effect occurs when the voltage applied to the moving electrode exceeds a critical value, causing the system to lose its stationary configuration. A semi-linear elliptic equation with the Laplace operator and the first boundary condition was used for mathematical modeling of the process. To construct an approximate solution of the problem, it is suggested to use the methods of nonlinear analysis in semi-ordered spaces, in particular, the results of V. I. Opoitsev on the solvability of nonlinear operator equations with a heterotone operator. The boundary value problem modeling the nanoelectromechanical system is reduced to the integral Urysohn’s equation using the Green – Rvachev’s quasi-function method, which allows us to expand the application of the two-sided approximation method for domains of fairly arbitrary geometry. The article substantiates the possibility of constructing two-sided approximations to a positive solution of the problem, namely: a computational scheme is given, conditions for its convergence to a single positive solution of the problem under consideration are obtained, and an error estimate is obtained. The method is illustrated by computational experiments for a problem considered in a rectangular domain. The results of computational experiments are presented in the form of numerical and graphical information.
El tratamiento del amor en la obra de Andréi Tarkovski
Authors: Domínguez Tórtola Ángel
Published: January 2023

Examinamos la obra del cineasta ruso Andréi Tarkovski con el fin de rastrear los diferentes tipos de amor que, a nuestro juicio, se dan cita en ella, a saber: amor a la pareja, a la familia, a la patria y a la humanidad. Abordar una cuestión como la del amor comporta numerosas dificultades, ya que se trata de un concepto escurridizo y multívoco. Por ello, trataremos de penetrar en la cuestión del amor pero siempre desde la mirada y el pensamiento de Tarkovski. No en vano, el objetivo anhelado no es otro que explorar la concepción amorosa de este director y mostrar cómo ese amor quedó plasmado en el celuloide.
Viviendo el periodo Sengoku con el anime Dororo
Authors: Bonillo Claudia
Published: January 2023

El pasado lleva siendo fuente de inspiración para las artes de Japón desde tiempos remotos. Empezando por el género literario de los gunki monogatari en el periodo Heian (794-1185/1192), pasando por las xilografías ukiyo-e del periodo Edo (1603-1868) y llegando hasta el cine jidaigeki del siglo XX, en la actualidad el anime histórico es el principal responsable de seguir enriqueciendo esta tradición artística. Es especialmente recurrente inspirarse en el periodo Sengoku (1467/1477-1603) o «era de los estados combatientes», caracterizado por la ausencia de un poder centralizado. Si bien las adaptaciones de esta época tienden a girar alrededor de personajes concretos, en el extremo opuesto tenemos el anime Dororo, desarrollado por el estudio MAPPA en 2019, adaptación actualizada de la serie homónima escrita e ilustrada por Tezuka Osamu, apodado el Dios del Manga. Consideramos que la relevancia de la obra original, unida a la calidad técnica y artística de esta versión animada, la convierten en el caso de estudio idóneo con el que acercar a las aulas no sólo el Medievo japonés, sino también el interés por otras culturas como la japonesa.