bluuebunny/crossref_metadata_2025 huggingface dataset:
Baş Etme Yetkinliğinin Yordayıcısı Olarak Psikolojik Esneklik
Authors: ACAR Sinem
Published: June 2022

Bu çalışmanın genel amacı baş etme yetkinliği ile psikolojik esneklik arasındaki yordayıcılık ilişkisinin incelenmesidir. Baş etme yetkinliği inancı, bireyin stresli ve tehdit içeren yaşam olaylarını yönetebilme kapasitesine ilişkin algısı; psikolojik esneklik, bilinçli bir insan olarak içinde bulunulan ana erişme ve o durumun izin verdiği ölçüde kişinin seçtiği değerler doğrultusunda davranmasıdır. Araştırma, nicel araştırma yönteminin kullanıldığı tarama modelinde tasarlanmıştır. Araştırmanın örneklemi bir devlet üniversitesinde farklı bölümlere devam etmekte olan 1. ve 2. sınıf öğrencileri oluşturmaktadır. Örneklem 72’si kadın, 64’ü erkek olmak üzere toplam 136 kişiden oluşmaktadır. Çalışma grubunun yaş ranjı 17-24 olup, yaş ortalaması 21.42 (Ss: 1.76)’dir. Araştırmada veri toplama aracı olarak baş etme yetkinlik düzeyini ölçmek üzere Baş Etme Yetkinliği Ölçeği ve psikolojik esneklik düzeyini ölçmek üzere Kabul ve Eylem Formu-2 kullanılmıştır. Analiz sonuçlarına göre, psikolojik esneklik baş etme yetkinliğininin toplam varyansının %16’sını açıklamaktadır. Araştırmanın bulguları litaratürdeki benzer araştırmalar ile paralellik göstermektedir. Elde edilen sonuçlar literatür ışığında tartışılmıştır. Araştırmanın sınırlılıkları ve sunulan önerileri sunulmuştur.
Tuboovaryan apseli hastalarda sistemik inflamatuvar belirteçlerin medikal tedavi başarısızlığını öngörmedeki yeri
Authors: ERTÜRK AKSAKAL Sezin , GÜVENÇ SAÇINTI Huriye , KİYKAC ALTINBAŞ Şadıman , TAPISIZ Ömer Lütfi , ENGİN-ÜSTÜN Yaprak
Published: June 2022

Amaç: Tuboovaryan apse (TAO) olgularında sistemik inflamatuar belirteçler ve Aspartate aminotransferaz/Platelet Index (APRİ) skorun medikal tedavi başarısızlığını öngörmede yeri olup olmadığı araştırıldı. Gereç ve Yöntem: Ağustos 2016 – Ekim 2020 tarihleri arasında TOA tanısı ile yatırılarak tedavi edilen 240 hasta çalışmaya dâhil edildi. Hastaların demografik ve klinik özellikleri, tanı anında bakılan C- Reaktif protein (CRP), Nötrofil lenfosit oranı (NLR), Platelet lenfosit oranı (PLR) ve APRI skoru dosya kayıtlarından elde edildi. Sadece medikal (n=74) tedavi alan veya cerrahi tedavi gereken hastalarda (n=166) bu parametrelerin medikal tedavi başarısızlığını öngörmedeki yerleri araştırıldı. Bulgular: Cerrahi tedavi alan hastaların sadece medikal tedavi alanlara göre ortalama yaşı (40,95 ± 6,96 ve (38,09 ± 7,69), apse boyutu (67,57 ± 19,86 mm ve 52,78 ± 16,63 mm), CRP değeri (140,61 ± 110,88 ve 75,24 ± 36,64 mg/L), beyaz küre (13818,86 ± 5445,80 ve 11845,31 ± 4424,39 μL), nötrofil (11146,81 ± 5284,83 ve 9242,03 ± 4278,60 μL) ve NLR değeri (9.52 ± 6.88 ve 6.64 ± 6.30) anlamlı olarak daha yüksek bulundu. Receiver Operating Characteristics (ROC) eğrisi analizi (95% 0,531-0,682) ile CRP’nin >11,57 olmasının %63,3 sensitivite, %55,4 spesifite ile medikal tedavi başarısızlığını öngördüğü saptandı. Sonuç: NLR, PLR ve APRI skoru cerrahi tedavi gereksinimini öngörmede etkisizdir. CRP başvuru anında cerrahi tedavi gereksinimini belirlemek adına kullanılabilecek bir belirteçtir.
Analisis Perbandingan Implementasi Metode MADM dan Fuzzy MADM SAW Pada Sistem Pendukung Keputusan
Authors: Purnomo Agus Sidiq , Rozi Anief Fauzan
Published: June 2022

There are so many studies that use the Multi-Attribute Decision Making (MADM) method as a solution in Decision Support Systems. In addition, there are also many studies that use additional fuzzy which is implemented in the MADM method which is commonly referred to as Fuzzy MADM. For example, using Simple Additive Weighting (SAW), which one is closer to the best solution, whether to use MADM SAW or FMADM SAW, which one is better to use.

Based on these problems, in this study analysis will be carried out regarding which method is closer to the best solution to be implemented in the case of Decision Support System between MADM and FMADM, in this case using the case of selecting the best graduates in the study program and the SAW method.

Based on the results of the discussion in this study, it can be concluded that the implementation of MADM uses SAW, with 2 approaches, namely: Likert and fuzzy scales. The results obtained from the comparison of assessment ranges using the Likert and fuzzy scales obtained suitability of 100%. While the results of testing using RSD on Likert and fuzzy scales obtained the same results, namely 12.24%. The use of a Likert scale or fuzzy numbers has no effect, what affects the results is the range of the rating scale.
Aplikasi Data Mining Asosiasi Barang Menggunakan Algoritma Apriori-TID
Authors: Asana I Made Dwi Putra , Sudipa I Gede Iwan , Mayun A.A. Tri Wulandari , Meinarni Ni Putu Suci , Waas Devi Valentino
Published: June 2022

Information about consumer spending patterns is needed by retail companies in determining promotion strategies, placing merchandise on shelves, and inventory management. Most applications in retail companies only produce information from the company side. Applications owned by the company have not been able to generate transaction activity information from the customer side. The transaction activity information from the customer side is knowing consumer spending patterns in terms of buying goods. This information can overcome problems that are often faced by companies, namely customer complaints when there is a vacancy in inventory of pairs of goods that are often purchased by customers. This article describes the application of association data mining with the Apriori TID algorithm. Apriori-TID is a development of the Apriori algorithm. Apriori-TID plays a role in finding frequent itemsets based on minimum support. The application can generate goods association rules based on the minimum support and confidence values entered by the user. The association data mining application features dataset import, dataset analysis, and print analysis result reports. The association rules generated by the application are evaluated using the lift ratio method. The number of transactions, minimum support, and minimum confidence affect the number of rules generated by the application.
Prophylaxis of Infective Endocarditis: A Cross Sectional Survey among Physician Members of the Portuguese Society of Cardiology
Authors: De Sousa Catarina , Almeida Ana G. , Pinto Fausto J.
Published: June 2022

Introduction: In the last decade, the downgrading of indications for antibiotic prophylaxis for infective endocarditis caused an uncertain impact on the incidence of this condition. Since no data is available on the practice of infective endocarditis prophylaxis in Portugal, we aimed to characterize the pattern of antibiotic use for infective endocarditis prophylaxis and the compliance/awareness of scientific guidelines among physician members of the Portuguese Society of Cardiology.Material and Methods: A cross sectional observational study was conducted. An online self-completed questionnaire with 12 items on infective endocarditis prophylaxis was sent to 1330 physicians, specialists and residents, members of the Portuguese Society of Cardiology. In addition, descriptive statistical analysis was performed.Results: Two hundred and fifty-three valid questionnaires were responded. Eighty-seven per cent of respondents were cardiologists (specialists or residents), mostly between 30 and 40 years old (26.7%) and 50 to 80 years old (44.3%). The majority (83.0%) follow the European scientific guidelines. Still, 61.0% had or may have had doubts regarding prophylaxis of infective endocarditis in certain patients. Variable adherence to scientific guidelines was noted. Further scientific evidence was required by 60.6% of respondents.Conclusion: Infective endocarditis prophylaxis was generally guided by European scientific guidelines among physicians of the Portuguese Society of Cardiology. There was, however, an evident discrepancy between the guidelines and real-world perception of the risk of infective endocarditis. This highlights the sensed gap in accessing more robust scientific evidence.
Do SNPs in Glutathione S-Transferase-Omega Allow Predictions of the Susceptibility of Vertebrates to SARS-CoV-2?
Authors: Hancock John T. , Veal David , Craig Tim J. , Rouse Ros C.
Published: June 2022

Infection with the SARS-Cov-2 virus causes COVID-19 in humans and is the cause of the pandemic around the world in 2020 and on. However, some animals have been found to be susceptible to the virus too. This has included the non-human primates, dogs, cats, and mustelids. Mink, and very recently hamsters and deer, have been shown to be able to contract the virus and pass it back to humans. However, which animals are susceptible to the virus has been very hard to predict. Many groups have looked at the sequence homology of the angiotensin converting enzyme 2 (ACE2), a receptor for the SARS-Cov-2 virus, across species, but this has had limited success. Similar work on other proteins such as transmembrane serine protease 2 (TMPRSS2), neuropilin-1, and furin have also been unfruitful. Recently, it has been suggested that single nucleotide polymorphisms (SNPs) in the glutathione S-transferase-omega (GSTO) genes of humans could alter viral susceptibility. Therefore, here, the presence of related sequences in vertebrates has been investigated. The SNPs in the GST-omega-1 (GSTO1) gene reported to increase COVID-19 in humans do not appear in the vertebrate species. However, the GST-omega-2 (GSTO2) SNP is represented in several vertebrate species known to have contracted the SAR-CoV-2 virus. Of course, animals may contain unknown SNPs at disruptive points in these genes too. In summary, GSTO1 genes are unlikely, at least at the moment, to be of value in predicting the susceptibility of an animal to the SARS-CoV-2 virus or disease progression, but a further study of the GST-omega-2 genes would be worthwhile. Therefore, more work on SARS-CoV-2 infections on vertebrates is recommended.
(First Online: June 8, 2022)
THE THREE-YEAR SURVIVAL RATE OF CERVICAL CANCER PATIENTS AT REFERRAL HOSPITAL IN SOUTHERN SUMATRA, INDONESIA
Authors: Zubaidah Zubaidah , Sitorus Rico Januar , Flora Rostika , Tantrakarnapa Kraichat
Published: June 2022

Background: Cervical cancer is the second most common cancer and the third leading cause of death in Indonesia. Purpose: This study aims to identify the 3-year survival rate of cervical cancer patients and its prognostic factors in a referral hospital in Southern Sumatra, Indonesia. Methods: Cohort retrospective study using secondary data from medical records of cervical cancer patients from January 2014 until December 2016. Data of each patient was evaluated for 36 months since the patients were firstly diagnosed with cervical cancer. Kaplan Meier curve was used to determine the survival rate and identify the proportional hazard assumption. The Cox regression model was utilized to determine the survival rate and Hazard Ratio (HR). Results: There were 274 of 799 cervical cancer patients who met the inclusion criteria. The 3-year survival rate for cervical cancer patients at survival rate was around 65%, and prognostic factors related to the survival of cervical cancer patients with p-value <0.05, i.e. age (HR=0.51; 95%CI=0.29-0.90), metastasis (HR=2.43; 95%CI=1.28-4.61), and completeness of therapy (HR=7.23; 95%CI=3.82-13.71. The complication was a confounding factor with metastasis and survival rate. Conclusion: The 3-year survival rate for cervical cancer patients at Mohammad Hoesin Hospital Palembang (RSMH) was 65%. The prognostic factors for the survival rate were age, metastasis, and completeness therapy. It was essential for cervical cancer patients to adhere to the therapy program recommended by doctors to increase the survival rate.
THE IMPACT OF KNOWLEDGE, ATTITUDE AND PRACTICE OF EATING BEHAVIOR ON STUNTING AND UNDERNUTRITION IN CHILDREN IN THE AGRICULTURAL AREA OF JEMBER DISTRICT, INDONESIA
Authors: Marchianti Ancah Caesarina Novi , Rachmawati Dwita Aryadina , Astuti Ida Srisurani Wiji , Raharjo Angga Mardro , Prasetyo Rony
Published: June 2022

Background: Indonesia as an agricultural country is still having nutritional problems (stunting and undernutrition) caused by mothers’ lack of knowledge, attitude and practice of eating behavior. Purpose: This research aims to investigate the impact of knowledge, attitude, and practice of eating behavior of mothers of children under five on stunting and undernutrition prevalence in the agricultural communities in Jember. Methods: This cross-sectional research used questionnaires as a method to collect data from respondents i.e. mothers who have toddlers about the knowledge, attitudes and practice of eating behavior. The research was conducted in 2018-2019 in Jember. A total of 414 respondents who met the inclusion criteria (those resided in the study area and were willing to participate in this study) were chosen through random sampling. The data were then analyzed by using Spearman rho’s test to search the effect of the knowledge and attitudes of the mothers of under fives toward stunting and undernutrition. While eating behavior was described based on the results of interviews with respondents on 2x24 hours of food recall and food frequency questionnaires.  Results: This study showed that knowledge and attitudes of mothers regarding eating behavior were related to the occurrence of stunting (p = 0.01; p = 0.04) and malnutrition (p = 0.04), except for the attitude variable towards malnutrition (p = 0.81). Data analysis results regarding eating behavior showed that there was still a lack of fulfillment of certain nutrients, both macronutrients (fiber) and micronutrients (Vitamin B1, Vitamin C, Vitamin E, Potassium, Sodium, Calcium and Folic Acid.) to the RDA reference which was recorded as severe deficiency in 60-97% of children under five. Conclusion: Adequate knowledge and attitudes of mothers of diet can be a factor that prevents nutritional problems (stunting and malnutrition). The consumption pattern assessed showed that there was still a lack of fulfillment of certain nutrients both macro (fiber) and micronutrients against RDA reference. Further research needs to be done to explore the right promotive and prevention approach based on the lack of nutrition found in each area.
RISK OF INTERNET ADDICTION AMONG ADOLESCENTS WITH ATTENTION-DEFICIT/HYPERACTIVITY DISORDER (ADHD) DURING THE COVID-19 PANDEMIC
Authors: Erliana Febria Rike , Setiawati Yunias , Aoyama Henry , Ardani I Gusti Ayu Indah
Published: June 2022

Background: In lieu of COVID-19, adolescents are forced to carry out their schoolwork, social and leisure activities online. Excessive internet use can have a negative impact on psychological, social, physical, spiritual, and financial well-beings. Such phenomenon is called internet addiction, and its highest prevalence is observed among adolescents with Attention-Deficit/ Hyperactivity Disorder (ADHD). They have difficulty focusing on less attractive routines, thus they tend to have impaired daily functioning. So, internet addiction co-occuring with ADHD among adolescents warrants serious clinical attention. Purpose: This literature aims to study the risk factors and management of comorbidity of internet addiction with ADHD in adolescents. Methods: A literature review of studies investigating Internet Addiction Risk in Adolescent with Attention-Deficit/Hyperactivity Disorder (ADHD). Non-English articles were set as the exclusion criteria.  Search criteria in this rewiew includes ‘internet addiction’, ‘ADHD’, ‘comorbidity’, and ‘adolescent’. Results: Adolescents with ADHD are at a heightened risk of developing internet addiction. Impulsivity, executive dysfunction, motivational dysfunction, social skill deficits and subpar attachment bonds were the primary reasons for the increased risk. Conclusion: Attempts to increase awareness on the internet addiction susceptibility among adolescents with ADHD, particularly in this COVID-19 pandemic.
Characteristics Energy, and Protein Intake of Pregnant Women during The Covid-19 Pandemic and Its Relation with Infant Birth Weight
Authors: Usman Fahmil , Salimo Harsono , Nuhriawangsa Adi Magna Patriadi
Published: June 2022

The COVID-19 pandemic is an outbreak that has a risk of a food crisis and changes in diet that have an impact on the nutritional status of pregnant women and babies. This study was aimed to analyze the relationship between the characteristics of pregnant women in the third trimester and food intake during the COVID-19 pandemic with birthweight. This research used cross-sectional method with a sample of 91 third trimester pregnant women at the Pundong and Bantul 1 Community Health Centers, Bantul Regency, Yogyakarta, which were randomly selected. The data was collected using a questionnaire. The nutritional status was measured based on MUAC (Mid Upper Arm Circumference), food consumption was measured using SQFF (Semi-Quantitative Food Frequency) questionnaire, and birth weight was measured using a digital weight scale with an accuracy of 0.1 kg. Bivariate analysis was done using Fisher-Exact with 95% CI. The results showed that the characteristics of pregnant women in the third trimester such as education, income, occupation, and disease history had no relationship with birth weight; gestational age (p = 0.007) and nutritional status (p = 0.002) had a relationship with birth weight; energy intake had no relationship while protein had a relationship with birth weight (p = 0.001). The conclusion is that gestational age, nutritional status, and protein intake have a relationship with birth weight during the COVID-19 pandemic. Therefore, pregnant women should always pay attention to food intake and carry out regular pregnancy checks to health services to detect early abnormalities to prevent low birthweight.
The Potential of Phytochemicals Lycopene in Prevention of Bone Loss due to Decreased Estrogen Hormone in Humans and Experimental Animals
Authors: Erdayanti Fansurina yuli , Atmaka Dominikus Raditya , Kagawa Masaharu
Published: June 2022

Osteoporosis is a condition of decreased bone mass and disruption of bone microarchitecture that often occurs in the elderly. One of the causes of osteoporosis is menopause as reduced estrogen secretion increases bone resorption by osteoclasts activity, and the body’s oxidative stress. Currently, osteoporosis is still a major cause of morbidity and mortality in the elderly. Prevention is vital in reducing this disease. Recent studies have shown a reduction in bone loss with lycopene consumption. High serum lycopene is also reported to be associated with decreased protein oxidation and bone resorption in postmenopausal women. This literature aimed to examine and analyze the research results related to the potential of lycopene on bone loss based on molecular and clinical research evidence in preventing osteoporosis in elderly women. Literature review on published papers in English in the last 10 years (2011 – 2021) was conducted using electronic database. Reviewed experimental and cohort studies on elderly women and experimental animals showed influence and effect of lycopene on bone loss. Lycopene may contribute in reduction of oxidative stress caused by reduced secretion of estrogen.
Factors Affecting The Choices of Healthy Diet among Adolescents in Rural Areas
Authors: Dewanti Ritma , Probandari Ari , Mulyani Sri
Published: June 2022

Many adolescents tend to pick unhealthy diets with high amount of sugar, salt and fat, while the number of adolescents who consume vegetables and fruit is relatively low. As adolescents begin to pick their own diets by themselves, there are certain reasons behind each of their preferences in foods. This study was aimed to analyze the factors affecting the choices of healthy diet among adolescents in rural areas. This was quantitative research with analytical and observational research method with a cross sectional design. The data sampling method used in this study was a multistage random sampling method. This research was conducted to 160 respondents with a population of 1,143 from 10 different high schools. The sample size was calculated using the OpenEpi software. The data on factors or reasons behind the choice of healthy diet was taken using the Food Choice Questionnaire (FCQ), while the data on the choices of healthy foods was taken using a structured questionnaire, both of which had been tested for validity and reliability. The collected data were analyzed using the Spearman Rank test. The main reasons that can influence adolescents to pick healthy diets in rural area were for healthiness concerns, the natural contents of the foods, and body weight control (BW) (p=<0.005). It is recommended for adolescents to optimize their knowledge and skills in food selection, especially healthy food.
Impact of COVID-19 on increasing female genital mutilation (FGM) in Africa: A study of Tanzania and Nigeria
Authors: Massay Emmanuel Michael , Susanti Emy , Sutinah Sutinah
Published: June 2022

Women’s sexual and reproductive health and rights (SRHR) have been undermined from time to time due to female genital mutilation (FGM). Women and girls experiencing FGM in many developing countries, including Tanzania and Nigeria. The aim of this study is to investigate the problems that occurred during the COVID-19 pandemic, which contributed to the high rates of FGM in Tanzania and Nigeria. This study uses a qualitative method to see the prevalence of FGM in both countries which has increased since the COVID-19 pandemic. This study is supported by the Patriarchal theory of Sylvia Walby, which explains why men try to oppress and control women as figures who dominate society. The study results show that both Nigeria and Tanzania have seen an increase in FGM amid COVID-19, with school closures placing teenage girls at the highest risk of FGM. The study concludes that the government, private institutions, and other development stakeholders should work together to find solutions to assist communities and families in ending FGM. If these efforts are implemented, then the 2030 sustainable development agenda can become a reality in ending FGM in Nigeria and Tanzania.
Variations of Islam and democracy in Muslim countries: From Islamic countries to secular Muslim countries and its relevance to the discourse of Islam and democracy
Authors: Zulfadli Zulfadli
Published: June 2022

The phenomenon of Islam and democracy in Muslim countries is practiced differently between Muslim countries with an Islamic state and Muslim countries with a secular pattern. This article wants to examine and reassess the view of Islamic exceptions or “Islamic exceptionalism” on the scarcity of democracy in Muslim countries with case studies of regime variations found in Muslim countries. This article analyzes the variation of Islam and democracy in Muslim countries, with a comparative method using data from the democracy indexing agency. There are four variations of Muslim countries: Islamic countries, semi-Islamic countries, secular countries, and semi-secular countries. This study shows that, from the four variations of the Islamic world, none of the Islamic countries has succeeded in achieving full democracy (full democracy). Three Muslim countries have a flawed democracy (flawed democracy), namely Malaysia, Indonesia, and Tunisia. The rest of the Muslim countries are under a political system controlled by the military (hybrid democracy) and authoritarianism. In addition, this article finds that social, political, cultural, and agency tools and support in supporting democratic values are still the main problems that harm the scarcity of democracy in Muslim societies
An overview of resistance to Human epidermal growth factor receptor 2 (Her2) targeted therapies in breast cancer
Authors: Elshazly Ahmed M. , Gewirtz David A.
Published: June 2022

Breast cancer (BC) is the second most common cause of cancer-related deaths and the most frequently diagnosed cancer in females. Among breast cancer types, HER2-positive breast cancer occurs in nearly 20% of human breast cancers and is associated with increased aggressiveness, poor prognosis, and shortened overall survival. HER2+ breast cancer is currently managed with multidisciplinary treatment strategies including surgery, radiation, chemotherapy, and targeted therapy. Drug resistance remains a continuing challenge, especially to targeted therapy utilizing monoclonal antibodies and tyrosine kinase inhibitors. This review discusses some of the recent molecular mechanisms that are involved in the development of resistance to Her2-targeted therapies including the PI3K/Akt/mTOR pathway, IGF-IR, Src, c-MET, the PP2A family, CD36, p27kip1, and miRNAs.
Health System and Policy Analysis: Why There Is a Need for a Paradigm Shift in Our Approach to Improve Health Status of Brick-Kiln Migrant Workers in India?
Authors: Kajal Fnu
Published: June 2022

Urbanization is a global phenomenon and as the economies are shifting from rural based subsistence to services based, the net flow of migration is inevitable. Unfortunately, In India, migration is very poorly understood. India is next to China in production of bricks, accounting for nearly 13% of global annual bricks’ production. The condition of brick-kiln workers is pitiable, especially due to poor care available. They are exposed to health hazards such as various communicable diseases, sexually transmitted diseases and occupational health hazards. The diseases such as respiratory problems, allergies, gastrointestinal ailments and malnutrition are frequent in these populations. This paper reflects upon various policies that exist for the welfare of unorganised sector but do these workers qualify for these benefits? This paper provides empirical basis for paradigm shift for policy formulation to provide safety nets for migrant population and have better urban planning for future.
Alternative Approaches for Uncovering Phytoplasma Biodiversity and Vector Associations
Authors: Trivellone Valeria , Cao Yanghui , Dietrich Christopher H.
Published: June 2022

Despite several decades’ effort to detect and identify phytoplasmas (Tenericutes: Mollicutes) using PCR and Sanger sequencing focusing on diseased plants, knowledge of phytoplasma biodiversity and vector associations remains highly incomplete. To improve protocols for documenting phyto-plasma diversity and ecology, we used DNA extracted from phloem-feeding insects and com-pared traditional Sanger sequencing with a next-generation sequencing method, Anchored Hy-brid Enrichment (AHE) for detecting and characterizing phytoplasmas. Among 22 of 180 leaf-hopper samples that initially tested positive for phytoplasmas using qPCR, AHE yielded phyto-plasma 16Sr sequences for 20 (19 complete and 1 partial sequence) while Sanger sequencing yield-ed sequences for 16 (11 complete and 5 partial). AHE yielded phytoplasma sequences for an addi-tional 7 samples (3 complete and 4 partial) that did not meet the qPCR threshold for phytoplasma positivity or yielded non-phytoplasma sequences using Sanger sequencing. This suggests that AHE is more efficient for obtaining phytoplasma sequences. Twenty-three samples with sufficient data were classified into eight 16Sr subgroups (16SrI-B, I-F, I-AO, III-U, V-C, IX-J, XI-C, XXXVII-A), three new subgroups (designated as 16SrVI-L, XV-D, XI-G) and three possible new groups. Our results suggest that screening phloem-feeding insects using qPCR and AHE sequencing may be the most efficient method for discovering new phytoplasmas.
Post-Transcriptional Effects of miRNAs on PCSK7 Expression and Function: miR-125a-5p, miR-143-3p and miR-409-3p as Negative Regulators
Authors: Malakootian Mahshid , Naeli Parisa , Mowla Seyed Javad , Seidah Nabil G.
Published: June 2022

The regulatory mechanism of PCSK7 gene is still unknown, although its encoded protein PC7 is the most ancient and highly conserved of all proprotein convertases and exhibits enzymatic and non-enzymatic functions in liver triglyceride regulation. Bioinformatics algorithms were used to predict regulatory microRNAs (miRNAs) of PCSK7 expression. This led to the identification of 4 miRNAs, namely miR-125a-5p, miR-143-3p, miR-409-3p, and miR-320a-3p, with potential binding sites on the 3’-untranslated region (3′-UTR) of human PCSK7 mRNA. The expression patterns of these miRNAs and PCSK7 mRNA were assessed in three different cell lines with quantitative polymerase chain reaction (qPCR), which revealed reciprocal expression patterns between the expression levels of the four selected miRNAs and PCSK7. Next, the interactions and effects of these miRNAs on PCSK7 expression levels were investigated via cell-based expression analysis, dual-luciferase assay, and Western blot analysis. The data revealed that PCSK7 mRNA levels decreased in cells transfected with vectors overexpressing miR-125a-5p, miR-143-3p, and miR-409-3p, but not miR-320a-3p. The dual-luciferase assay demonstrated that the above 3 miRNAs could directly interact with putative target sites in PCSK7 3′-UTR and regulate its expression, whereas miR-320-3p exhibited no interaction. Western blot analysis further revealed that overexpression of miR-125a-5p in Huh7 cells inhibits the expression and ability of PC7 to cleave human transferrin receptor 1. Our results support a regulatory role of these miRNAs in PCSK7 expression and function and opens the way to assess their roles in the regulation of PC7 activity in vivo in the development of hepatic steatosis.
Structural and Dynamical Properties of Liquid Water Increase Turbulent Flows
Authors: Tozzi Arturo , Peters James , Mariniello Lucio
Published: June 2022

Turbulence is a fluid dynamic problem refractory to mathematical treatment. Examining a theoretical model of liquid water flowing in a cylinder at different Raleigh numbers, we propose a novel approach to elucidate the first stages of turbulent flows. The weakly bonded molecular assemblies of liquid water form a fluctuating branched polymer in which every micro-cluster displays different density. Against the common view of liquid water as an incompressible and continuous fluid, we suggest that the occurrence of transient local aggregates could be able to generate the vortices and eddies that are the hallmarks of turbulence. We quantify the local changes in velocity, diameter and density required to engender “obstacles” to the average flow. Then, we show how these microstructures, equipped with different Raleigh numbers and characterized by high percolation index, could generate boundary layers that contribute to micro-vortices production. We conclude that the genesis of turbulence cannot be assessed in terms of collective phenomena, rather is sustained, among many other factors, by the underrated microscopic inhomogeneities of fluids like liquid water.
A Primer on the Factories of the Future
Authors: Anumbe Noble , Saidy Clint , Harik Ramy
Published: June 2022

In a dynamic and rapidly changing world, customers’ often conflicting demands plus fluid economic requirements, often driven by geo-politics, have continued to evolve, out-striping the capability of existing production systems. With its inherent shortcomings, the traditional factory has proven to be incapable of addressing these modern-day manufacturing challenges. Recent advancements in Industry 4.0 have catalyzed the development of new manufacturing paradigms (or smart factory visions) under different monikers (e.g., Smart factory, Intelligent factory, Digital factory, Cloud-based factory etc.) would help fix these challenges. Due to a lack of consensus on a general nomenclature for these manufacturing paradigms, the term Future Factory (or Factory of the Future) is here used as a collective euphemism, without prejudice. The Future Factory constitutes a creative convergence of multiple technologies, techniques and capabilities that represent a significant change in current production capabilities, models, and practices. It is a data-driven manufacturing approach and system that harnesses intelligence from multiple information streams i.e., assets (including people), processes, and subsystems to help create new forms of production efficiency and flexibility. Serving both as a review monograph and reference companion, this paper details the meanings, characteristics, and technological underpinnings of the Future Factory. It also elucidates on the architectural models that guide the structured deployment of these modern factories with particular emphasis on three advanced communication technologies capable of speeding up advancements in the field. It not only highlights the relevance of communication between assets but also lays out mechanisms to achieve these interactions using the Administration shell. Finally, the paper also discusses the key enabling technologies that are typically embedded into bare bone factories to help improve their visibility, resilience, intelligence, and capacity, in addition to how these technologies are being deployed and to what effect. At the onset of the study, we were interested in developing a monograph which would serve as a comprehensive but concise review of general principles, fundamental concepts, major characteristics, key building blocks and implementation guidelines for the Future Factory within the overall context of the manufacturing ecosystem, in the age of Industry 4.0. Our hope is that this paper would enrich the extant literature on advanced manufacturing, help shape policy and research, and provide insights on how some of the identified pathways can be diffused into industry.
Energetic and hydrodynamic substitutions for Vlasov-Poisson and its astrophysical consequences
Authors: Fimin Nikolay Nikolaevich , Nikoforov Aisen Gavril'evich
Published: June 2022

This preprint describes the system of Vlasov–Poisson equations in the self-consistent gravitational potential of cosmological genesis, and shows a case that leads to the formation of coherent pseudochaotically distributed ”walls” of the cosmological structure.
Trauma-Informed Home Visiting Models in Public Health Nursing: An Evidence-Based Approach
Authors: Ballard Julianne , Turner Laura , Cuca Yvette P. , Lobo Brittany , Dawson-Rose Carol S.
Published: June 2022

Traumatic experiences can have significant health effects, particularly when they are experienced during childhood. Structural determinants of health including environmental disasters and limited access to mental health services and affordable housing can contribute additional stress for parents with a personal history of childhood adversity. These factors can directly affect their children, contributing to intergenerational trauma.

Pregnant people and families with young children are often referred to public health nursing maternal and child home visiting (HV) programs when there are concerns about historical or evolving childhood trauma. The strict eligibility and participation requirements of existing evidence-based maternal and child HV programs can exclude families that have experienced or are experiencing childhood trauma and its effects and can limit innovation by public health nurses, a hallmark of the field.

Therefore, we advocate and describe the implementation of the Trauma Informed Approach in Public Health Nursing (TIA PHN) model, which incorporates a trauma-informed approach into a traditional maternal and child HV program in 3 California counties. TIA PHN, which began enrollment in March 2021, involves public health nurses and community health workers and integrates program evaluations in pursuit of evidence-based status. (Am J Public Health. 2022;112(S3):S298–S305. https://doi.org/10.2105/AJPH.2022.306737 )
Analisis profitabilitas pada perusahaan pertambangan batubara yang terdaftar di bursa efek Indonesia
Authors: Nurron Muhammad , Ichsanuddin Nur Dhani
Published: June 2022

Indonesia is a developing country that has abundant natural resources potential, one of which is coal mining which is one of Indonesia's leading commodities, one of the efforts to achieve the goal of coal mining companies is always trying to maximize profits. Many factors can affect a company's profitability level. This study aims to analyze the influence of variable liquidity, company size, sales growth, and debt to asset ratio on the profitability of manufacturing companies in Indonesia.The population of this study is coal mining sub-sector companies registered in IDX in 2014 – 2018. The sample was taken using purposive sampling method so that 20 companies qualified as samples were obtained. This study uses regression analysis method to determine the influence of free variables consisting of liquidity, company size, sales growth, debt to asset ratio to profitability (ROA) of the company.The results showed that variable liquidity and also the size of the company contributed to the profitability of the company, while sales growth and also debt to asset ratio did not contribute to the profitability of coal mining companies.
Balancing Consumer Rights and Business Interests in Online Cross-Border Consumer Contracts
Authors: Ten Wolde Mathijs H.
Published: June 2022

Protection of consumers as weaker parties is an important goal in Indonesian society and in Indonesian law. The same applies to the EU Member States. When it comes to crossborder consumer contracts, special rules are needed to ensure this goal can still be achieved. In this regard the European Union developed rules on jurisdiction and applicable law which apply both to situations exclusively connected with EU Member States and to international situations connected with third countries. The Brussels I Regulation pursues an objective of legal certainty which consists in strengthening the legal protection of persons established inthe European Union, by enabling the applicant to easily identify the court in which he may sue and the defendant reasonably to foresee before which court, he may be sued. The Rome I Regulation does the same for the law regulating the protection of the consumer. This way both the aims of protection of the weaker consumer and legal certainty on the side of the commercial party go hand in hand. Where legal certainty is an important precondition for international trade and thus for a nation’s economy, clear rules are needed. By presenting the EU rules in the dynamics of the caselaw of the European Court of Justice, this article aimsto contribute to the discussion on how future cross-border consumer protecting regulations could be shaped in Indonesia and ASEAN.
Application of cast parts in mechanical engineering
Authors: Sadokha M. A. , Andrushevich A. A.
Published: June 2022

Information about the volumes of castings production in various countries of the world is given. The situation with the castings production in the Republic of Belarus is considered in more detail. An outlook on the ways of further foundry production development is presented. Recommendations have been developed on the main areas of application of cast products in mechanical engineering.
To Clarify Decision on Action of Concentrated Force to Elastic Quarter-Space for Arbitrary Poisson’s Ratio
Authors: Bosakov S. V.
Published: June 2022

Previously, the author obtained an analytical solution for determining the vertical displacements of the homogeneous isotropic quarter-space face, which is affected by a vertical concentrated force. This expression gave an exact solution for determining the vertical displacements of a quarter-space face made of incompressible material and an approximate solution for a Poisson ratio different from 0.5. Later, in the published paper by S. V. Bosakov and P. D. Skachek “Action of Concentrated Force on 1/8 of Homogeneous Isotropic Space”, it was shown that by combining solutions for determining 

the vertical displacements of a quarter-space and a half-space from the action of concentrated forces, one can find vertical displacements for  one-eighth face of a homogeneous isotropic space. The resulting expressions allow solving contact problems for non-classical domains in the form of a quarter of a space and one eighth of a space. Below, the author obtains the first approximation for displacements of a quarter-space face from the action of a vertical concentrated force. In this paper, the author gives the first approximation for determining the vertical displacements of a quarter-space face from the action of a vertical concentrated force, widely using the special approximation method developed in the works of V. M. Alexandrov and allowing to calculate successfully improper integrals. The constructed graphs show good results when determining displacements with a Poisson’s ratio different from 0.5 and equal to 0.5. It should be noted that the approach indicated in the paper by S. V. Bosakov and P. D. Skachek can be successfully used in determining all displacements of the faces of one-eighth face of a homogeneous isotropic sharpened forces tangent to the edge of a quarter-space and this will allow to solve contact problems taking into account friction forces in the contact zone of the beam or plate.
Methodology for Forecasting Staffing in the Comprehensive Forecast of Scientific and Technological Progress and Directions for its Improvement
Authors: Saltanova I. V. , Sednina M. A.
Published: June 2022

Developing and implementing innovative goods, new product groups, services and technologies in all spheres of society in terms of «economic» global digitalization requires advanced training of existing personnel, as well as the emergence of new specialties and professions. In this aspect, it is necessary to forecast the need for personnel in new specialties and specializations, as well as to study the possibilities for advanced training and retraining of existing specialists. The experience of the Comprehensive Forecast of Scientific and Technological Progress (CF STP) of the Republic of Belarus for 2021–2025 and for the period up to 2040 is analyzed in terms of staffing for innovative development. The required human resources potential has been assessed by the method of an expert survey in the process of forming the CF STP. Forecasting the need for personnel in the CF STP had a number of limitations. These limitations could be partially eliminated when developing the next CF STP and other forecasts of the need for personnel in the innovation economy. The paper considers possible directions for improving the forecasting of the provision of the economy with personnel for innovative development. It is advisable to assess the availability of personnel in the economy, taking into account the study of the ratio of supply and demand for them in quantitative and qualitative aspects. Algorithms are proposed for assessing: the needs of the national economy in personnel for innovative development; availability of personnel for innovative development and their competencies in organizations of the real sector of the economy; opportunities of the education system for training personnel for innovative development. The improvement of the methodology for forecasting the availability of personnel will allow to identify the most promising areas of training personnel with the necessary competencies and qualifications capable of developing and implementing technological innovations for the further development of the Republic of Belarus.
An improved combined method of creating control forces and moments for an unmanned aerialvehicle
Authors: Lopuhov A. V.
Published: June 2022

improved combined (aerodynamic and gas-dynamic) method of creating control forces and moments.

The objectives of the study are to analyze the basic model of the combined control method and the possibility of using an improved model of the combined control method, at which the invariability of the mass and dimensional characteristics of the upgraded control object will be achieved with a simultaneous increase in the target quality (reduction of the final miss).

Research is based on the use of an improved method for creating control forces and moments, where the optimization of mass characteristics is made, for using of a smaller number of micropulse motors (only at the stages of acceleration and braking), and when setting the balancing position (maintaining a steady angle of attack), instead of impulse engines, a steering drive is used standard onboard stabilization system of an unmanned aerial vehicle aerodynamic control channel. Which ultimately made it possible to preserve the invariability of the mass characteristics of the aircraft being upgraded and to increase the accuracy of its guidance.

The results of experimental mathematical modeling confirm the effectiveness of the proposed synthesis.
Activity Analysis of the Fuyu North Fault, China: Evidence from the Time-Series InSAR, GNSS, Seismic Reflection Profile, and Plate Dynamics
Authors: Liu Bin , Jiang Qigang , Zhang Ziwen , Li Yuanhua , Shi Mengyao , Zhang Zhenchao , Shi Pengfei , Liu Huaxin , Zhang Sen , Wang Peng
Published: June 2022

Earthquake disasters are frequent, and the seismic intensity is large in Northeast China. Earthquake activity research is an important aspect of earthquake disaster management. We chose some unconventional means to study fault activity, to find updated activity evidence. The Ms 5.3 earthquake occurred near the Fuyu North Fault (FNF) of China on May 27, 2018. Using the Sentinel-1B descending orbit data from 2016 to 2019, the line-of-sight (LOS) surface deformation in the study area was calculated by using the small baseline subset (SBAS) method. After transforming to the horizontal EW deformation, the variance component estimation method was used for fusion reconstruction with the EW data of the surrounding GNSS stations. The polynomial least square method is used to fit the fault slip rate of three EW data on the surface trace of the FNF. The fitting results of the three regions show that the horizontal eastward distribution rate of the upper plate is significantly greater than that of the lower plate, which is left-lateral clockwise torsion. The vertical structural deformation caused by the growth strata of the upper and lower plates of the upper SYT2 seismic profile of the FNF is quantitatively calculated, and the thrust rate of the upper plate is 0.2 mm/y relative to that of the lower plate. Based on the Li Siguang chessboard structure model, we found that the compression stress in the north-south direction is gradually weakened, and the compression stress in the east-west direction is gradually enhanced. Through the Coulomb stress analysis, the three events of CMT only induced the historical focal location of the surrounding part. The events of 2017 did not induce the events of 2018, but the events of 2019 were related to the induced effects of 2017 and 2018.
Research on the Floor Rockburst of Panel Entry under the Mining Influence: A Case Study
Authors: Feng Hao , Ma Xiang , Zhao Yang , Jiang Lishuai , Wen Xinglin , Cong Qian , Wang Fangtian
Published: June 2022

The stability of the entries of longwall panels is the key to ensure efficient and safe production of coal mines. In order to solve the common problems of floor heave of panel entry in western China, based on a case study, this paper studies the rockburst instability mechanism of entry floor-induced mining by considering the results from a laboratory test, numerical simulations, and field practice. After testing, the coal and rock of the entry are hard and brittle. In particular under the action of impact dynamic load, its dynamic strength is higher and has a positive correlation with the impact pressure, which provides a mechanical premise for subsequent rockburst. Numerical simulation results show that with the mining of the panel, the vertical stress and the maximum principal stress of the floor are mainly concentrated in the coal pillar along the entry, and the area and degree of concentration continue to increase. The horizontal stress is mainly concentrated in the entry floor, which is distributed in the advanced range of the panel. The deformation rate of the entry roof and the ribs is stable, while the floor shows a “mutation” characteristic of not deforming when the panel is far away and suddenly rising when it is closer to the panel. The range of the plastic zone of the roof and floor remains unchanged, the ribs are further deepened, and the mechanical properties of the coal and rock mass are further weakened. The results of this study contribute to providing a reference for the control of surrounding rock of panel entry under similar geological and geotechnical circumstances.