bluuebunny/crossref_metadata_2025 huggingface dataset:
Control of human pancreatic beta cell kinome by GLP-1R biased agonism
Authors: Xiao Jiannan , Eid Liliane El , Buenaventura Teresa , Boutry Raphaël , Bonnefond Amélie , Jones Ben , Rutter Guy A , Froguel Philippe , Tomas Alejandra
Published: February 2023

Aim

To determine the kinase activity profiles of human pancreatic beta cells downstream of GLP-1R balancedversusbiased agonist stimulations.

Materials and methods

This study analysed the kinomic profiles of human EndoC-βh1 cells following vehicle and glucagon-like peptide-1 receptor (GLP-1R) stimulation with the pharmacological agonist exendin-4, as well as exendin-4-based biased derivatives exendin-phe1 and exendin-asp3 for acute (10-minute)versussustained (120-minute) responses, using PamChip® protein tyrosine kinase (PTK) and serine/threonine kinase (STK) assays. The raw data were filtered and normalised using BioNavigator. The kinase analyses were conducted with R, mainly including kinase-substrate mapping and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.

Results

The present analysis reveals that kinomic responses are distinct for acuteversussustained GLP-1R agonist (GLP-1RA) exposure, with individual responses associated with agonists presenting specific bias profiles. According to pathway analysis, several kinases, including JNKs, PKCs, INSR and LKB1, are important GLP-1R signalling mediators, constituting potential targets for further research on biased GLP-1R downstream signalling.

Conclusion

Results from this study suggest that differentially biased exendin-phe1 and exendin-asp3 can modulate distinct kinase interaction networks. Further understanding of these mechanisms will have important implications for the selection of appropriate anti-T2D therapies with optimised downstream kinomic profiles.
A frontosensory circuit for visual context processing is synchronous in the theta/alpha band
Authors: Bastos Georgia , Holmes Jacob T. , Ross Jordan M. , Rader Anna M. , Gallimore Connor G. , Peterka Darcy S. , Hamm Jordan P.
Published: February 2023

Visual processing is strongly influenced by context. Stimuli that deviate from contextual regularities elicit augmented responses in primary visual cortex (V1). These heightened responses, known as “deviance detection,” require both inhibition local to V1 and top-down modulation from higher areas of cortex. Here we investigated the spatiotemporal mechanisms by which these circuit elements interact to support deviance detection. Local field potential recordings in mice in anterior cingulate area (ACa) and V1 during a visual oddball paradigm showed that interregional synchrony peaks in the theta/alpha band (6-12 Hz). Two-photon imaging in V1 revealed that mainly pyramidal neurons exhibited deviance detection, while vasointestinal peptide-positive interneurons (VIPs) increased activity and somatostatin-positive interneurons (SSTs) decreased activity (adapted) to redundant stimuli (prior to deviants). Optogenetic drive of ACa-V1 inputs at 6-12 Hz activated V1-VIPs but inhibited V1-SSTs, mirroring the dynamics present during the oddball paradigm. Chemogenetic inhibition of VIP interneurons disrupted ACa-V1 synchrony and deviance detection responses in V1. These results outline spatiotemporal and interneuron-specific mechanisms of top-down modulation that support visual context processing.
LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility
Authors: Hwang Jae Yeon , Chai Pengxin , Nawaz Shoaib , Choi Jungmin , Lopez-Giraldez Francesc , Hussain Shabir , Bilguvar Kaya , Mane Shrikant , Lifton Richard P. , Ahmad Wasim , Zhang Kai , Chung Jean-Ju
Published: February 2023

Radial spokes (RS) are T-shaped multiprotein complexes on the axonemal microtubules. Repeated RS1, RS2, and RS3 couple the central pair to modulate ciliary and flagellar motility. Despite the cell type specificity of RS3 substructures, their molecular components remain largely unknown. Here, we report that a leucine-rich repeat-containing protein, LRRC23, is an RS3 head component essential for its head assembly and flagellar motility in mammalian spermatozoa. From infertile male patients with defective sperm motility, we identified a splice site variant ofLRRC23. A mutant mouse model mimicking this variant produces a truncated LRRC23 at the C-terminus that fails to localize to the sperm tail, causing male infertility due to defective sperm motility. LRRC23 was previously proposed to be an ortholog of the RS stalk protein RSP15. However, we found that purified recombinant LRRC23 interacts with an RS head protein RSPH9, which is abolished by the C-terminal truncation. Evolutionary and structural comparison also shows that LRRC34, not LRRC23, is the RSP15 ortholog. Cryo-electron tomography clearly revealed that the absence of the RS3 head and the sperm-specific RS2-RS3 bridge structure in LRRC23 mutant spermatozoa. Our study provides new insights into the structure and function of RS3 in mammalian spermatozoa and the molecular pathogenicity of LRRC23 underlying reduced sperm motility in infertile human males.
A Bayesian network for selecting improvement management tools to increase customer satisfaction in the construction industry: case study of Mexico
Authors: Delgado-Hernández David Joaquín , Palacios-Navarro Ulises Jairo
Published: February 2023

Purpose

The use of improvement tools in the construction sector has shown to be an important determinant of quality. Companies endeavoring to enhance their daily practices require assistance, evidence, standards, frameworks and quantitative models from existing experts to help them set out for the road. This paper is aimed to assist construction managers in the selection of tools to increase customer satisfaction.

Design/methodology/approach

This piece of research is based on the results of a previous empirical study on the use, within a sample of Mexican firms, of a set of more than 30 tools. It then proposes a Bayesian network (BN) to select them. By analyzing the variables under study, it is possible to establish their interaction and dependencies. The resultant BN comprises 24 nodes, and it is useful for choosing some tools that help to increase customer satisfaction.

Findings

Customers and their needs now have become more complicated and harder to meet than in the past. Then, the use of improvement tools that put quality at the heart of the management strategies is crucial for achieving customer satisfaction. In order to reduce prices, keep product quality and meet delivery times, these tools should be used on a daily basis. Along this line of thought, the overall results from the hypothetical scenarios explored in this were positive, reflecting the relevance of the proposed model. In particular, the use of tools for gathering customer needs, the utilization of technology and the implementation of a quality department are relevant for increasing customer satisfaction in the sector.

Research limitations/implications

The sample size could be further expanded. The customer satisfaction dimensions could be enhanced.

Practical implications

While the sample in which the investigation is based could be expanded along with the number of variables and their states, the BN can help practitioners in the global construction industry to improve their quality practices, to foster loyalty and to grow revenues.

Originality/value

Most of the research reported in the area of continuous improvement in construction focuses on qualitative considerations, and it is still scarce in terms of developing mathematical models for selecting existing tools and, ultimately, satisfying customer’s requirements. This investigation is aimed to bridge this gap in the literature.
Walking the talk towards sustainable consumption: interventions to promote the uptake of reprocessed construction materials
Authors: Tennakoon Gihan Anuradha , Rameezdeen Raufdeen , Chileshe Nicholas
Published: February 2023

Purpose

The uptake of reprocessed construction materials (RCMs) derived from demolition waste (DW) is limited, which questions the long-term sustainability of DW reverse logistics (RL). To address this gap, the current study focused on identifying informational and structural interventions to promote the uptake of RCMs among Australian construction professionals (CPs).

Design/methodology/approach

Following a qualitative research approach with thirty-one semi-structured interviews, the study explored potential interventions that can drive broader RCM usage. The study's strength lies in the in-depth qualitative insights gathered through extensive interviews with CPs experienced in using RCMs.

Findings

Sixteen informational and structural interventions to promote the uptake of RCMs were identified and mapped against the industry levels at which they should be implemented. RCM suppliers should focus on improving material quality, supply and marketing while minimising material costs. Governments should encourage using RCMs through incentivisation, supportive legislation and approval processes. The significance of awareness building and research was also recognised, which requires the collective efforts of suppliers, governmental and non-governmental bodies and educational institutes.

Originality/value

Despite the talk around sustainable consumption, the actual walk towards this is limited from a construction perspective, as seen through the low uptake of RCMs. This study attempts to bridge this mismatch by outlining informational and structural interventions that would drive CPs to walk the talk and use RCMs for construction applications. While most studies on DW RL have focused on improving waste recovery processes, this study takes a less-trodden path and explores the potential for developing markets for RCMs.
Visiting museums via augmented reality: an experience fast-tracking the digital transformation of the tourism industry
Authors: Khalil Sabine , Kallmuenzer Andreas , Kraus Sascha
Published: February 2023

Purpose

Augmented reality (AR) is an emergent technology that has been impacting and beneficial to various industries. This is especially the case in the tourism industry since the COVID-19 crisis. To enable and enhance the museum experience, AR technology can be used as a tool to manage visitors' experiences and adapt to the digital transformation of industries. This research work aims to explore the acceptance of museum visitors for the adoption of this technology. For this purpose, the technology acceptance model (TAM) is used as the research lens.

Design/methodology/approach

The authors collected 316 responses from a survey handed out to prior visitors of immersive exhibitions shown via AR at the Atelier des Lumières in Paris and analyzed them through a structural equation model approach.

Findings

The study’s findings explain the behavior of visitors when attending immersive exhibitions according to the TAM and highlight two new constructs that need to be considered when using the TAM with AR technology: user satisfaction and social mimetism.

Originality/value

The study’s findings support that implementing AR technology in the museum industry provides great opportunities for the tourism industry to recover from the economic crisis that followed from the COVID-19 health crisis. The authors identified new thriving concepts in the 21st century with the rise of social media, such as social mimetism, that propels visitors to have a positive attitude and intention to attend immersive exhibitions.
Management innovation and its relation to innovation outcomes and firm performance: a systematic literature review and future research agenda
Authors: Henao-García Edwin Alexander , Cardona Montoya Raúl Armando
Published: February 2023

Purpose

The main purpose of this review is to enhance the understanding of intellectual structure and outlook of management innovation research as an interesting and growing research field.

Design/methodology/approach

This systematic literature review examines the question, what is the relationship of management innovation with the performance of companies and with other types of innovation? The work also pursues to summarize theories, contexts, characteristics of the papers and methodologies with the purpose of facilitating further development and opportunities and priorities for future research.

Findings

The results suggest that management innovation is an interesting and growing research field; in its relation to different types of innovation and performance, it is a field explored with theoretical approaches, contexts and methodologies that begin to form a consolidated body of knowledge. However, through a critical analysis, this review highlights the gaps in the literature and provides suggestions for future studies to further explore the field. This revision contributes to the literature on management innovation summarizing the findings and contributions of research published in the field and its relationships with innovation and performance. It then identifies three comprehensive research streams, namely, future research on conceptualization, definitions and measurements; research on the level of analysis; and future research on management innovation drivers, antecedents and use as mediator/moderator variables.

Originality/value

Management innovation is an emerging research field that is characterized as a branch of research long ignored by more orthodox lines dedicated to technological innovation and topics in product and service development research.
Barriers to service transition in an innovation ecosystem: a qualitative study
Authors: Carneiro Dênio , Franco Mário , Rodrigues Margarida
Published: February 2023

Purpose

This study arises from the need to understand the servitization or service transition process in non-manufacturing firms and sets out from a taxonomy proposed in the literature (Lütjen et al., 2017). This study aims to identify the barriers to service transition in small and medium-sized enterprises (SME) participating in an innovation ecosystem and how these small firms can benefit from this strategy to develop in this scale.

Design/methodology/approach

A qualitative study was carried out based on multiple case studies, data being collected through semi-structured interviews with service business-people belonging to a science and technology park situated in an inland region of Portugal.

Findings

From content analysis, the results obtained indicated a lack of specialized personnel as the main barrier and as a strategy to overcome this situation these companies turned to business cooperation. This means that good management of this cooperation increases the quality of the services provided, as inter-organizational networks, through participation in ecosystems, can secure a wider set of resources and capacities.

Practical implications

This study shows that firms try out different service offers simultaneously and that innovation capacity increases constantly during service transition. Secondly, the study emphasizes the importance of innovation ecosystems, entrepreneurship, servitization and cooperation networks in promoting resilient and small ventures. Thus, this study can help owner-managers, SMEs and political decision-makers to make better informed decisions, which can be particularly relevant in scenarios of uncertainty and crisis.

Originality/value

This study draws conclusions in a little explored empirical area in the literature, challenging the widespread understanding that service transition is used only in manufacturing firms. This study provides clearer conceptual understanding of service transition from a network and relational perspective which, despite the perspective's relevance, still lacks research in the context of servitization.
Environmental sustainability performance and shareholder value: an international fuzzy-set qualitative comparative analysis
Authors: Jouber Habib
Published: February 2023

Purpose

Considering corporate governance (CG hereinafter) practices' variety across Anglo-American and European countries, this study relies on contingency and complexity theories to investigate the effect of environmental sustainability performance (ESP hereinafter) on shareholder value under various configurations of board of directors (BoD hereinafter), firm and country characteristics.

Design/methodology/approach

The author used the Thomson Reuters Environment Pillar Score (ASSET4) and the Total Shareholder Return to assess ESP and shareholder value respectively. The author applied a fuzzy-set qualitative comparative analysis (fsQCA hereinafter) to an unbalanced panel of 2,284 observations from 486 European and Anglo-American non-financial listed firms over the period 2016–2020.

Findings

The author found a positive association between ESP and shareholder value and he displayed notable differences between Anglo-American and European economies regarding causal predictors of this positive association. Within European firms operating under civil law code where investor protection is low and family ownership is widespread, ESP creates shareholder value under configurations of causal predictors that significantly differ from those of their Anglo-American peers. The author's findings are robust to different identification strategies.

Practical implications

This study assists researchers, practitioners, shareholders and policymakers the significant roles that BoD diversity, organisational and institutional traits are jointly playing as determinants of the ESP-shareholder value relationship.

Originality/value

The author's study offers a more encompassing, complete and theoretically richer picture of the key drivers and outcomes of ESP.
Work performance change during the Covid-19 pandemic under risk-as-feelings hypothesis for managers across Europe
Authors: Hamza Fadhila
Published: February 2023

Purpose

This study aims to examine the predictors of the managers’ work performance under the risk-as-feelings hypothesis during the Covid-19 pandemic in four European countries. Specifically, it aims to investigate the impact of risk-related job stressors and behavioral and emotional reactivities on non-managers and managers performance in risky circumstances.

Design/methodology/approach

The author assessed simultaneously the effects of occupational health risk perception and the resulting feelings and emotional state such irritability and commitment change, the effects of income and others organizational and personal variables as performance stressors. The author used a sample of 652 employees divided on two groups (71% non-managers and 23% managers). Data are obtained from the dataset in Prochazka et al., (2020) collected using online survey delivered to employees employed in their companies for a minimum of five months in the period between Mai and June 2020.

Findings

The results confirm the risk-as-feelings hypothesis and show significant effect of occupational health risk perception and associated emotional responses (irritability and commitment) on the work performance for non-managers’ group. However, for managers’ group the main determinant of work performance is the organizational commitment as explained by the job-demands-resources-model (JDRM).

Originality/value

The originality of this study is to employ the risk-as-feelings hypothesis (Loewenstein et al., 2001) in a management research question such as job performance predictors. Thus, this study contributes to the literature on job performance in two significant ways. First, it examines the risk-related job’s stressors as determinants of managers and non-managers performance under the risk-as-feelings hypothesis. Second, it tests the importance of functional differences as an approach to better investigate the framework of the JDRM (Bakker and Demerouti, 2017).
A continuous improvement implementation framework for manufacturing companies: a Delphi study-based approach for development and validation
Authors: McLean Richard Scott , Antony Jiju , Garza-Reyes Jose Arturo , Samadhiya Ashutosh
Published: February 2023

Purpose

Due to the absence of industry and region-specific implementation guides, change efforts, in particular continuous improvement implementations, continue to report high failure rates. The purpose of this paper is, therefore, to present a finalised implementation framework specifically tailored for manufacturing companies.

Design/methodology/approach

A conceptual framework derived from the existing literature is validated, through a Delphi study, by an expert panel to review its content and suitability for a practical application.

Findings

This paper proposes a finalised framework tailored to the practical needs of users. The results of the Delphi approach offer a phased implementation framework that provides an overview of the implementation process of continuous improvement initiatives and the key activities involved. The framework is suitable for use by both business leaders and continuous improvement practitioners with varying degrees of previous implementation experience.

Research limitations/implications

The research was carried out in the UK and is specifically focused on the manufacturing industry. It is therefore not clear the applicability of the framework presented to other regions and industries. The framework, although validated through several phases of research, still requires practical application and testing.

Originality/value

Business leaders and continuous improvement practitioners will benefit from having the necessary content presented in a manner that will promote its practical application. It has also been demonstrated that the framework is robust in its content, incorporating the literature findings as well as the experience of an expert panel encompassing 20 people.
Similarity assessment and model migration for measurement processes
Authors: Huber Meike , Agarwal Dhruv , Schmitt Robert H.
Published: February 2023

Purpose

The determination of the measurement uncertainty is relevant for all measurement processes. In production engineering, the measurement uncertainty needs to be known to avoid erroneous decisions. However, its determination is associated to high effort due to the expertise and expenditure that is needed for modelling measurement processes. Once a measurement model is developed, it cannot necessarily be used for any other measurement process. In order to make an existing model useable for other measurement processes and thus to reduce the effort for the determination of the measurement uncertainty, a procedure for the migration of measurement models has to be developed.

Design/methodology/approach

This paper presents an approach to migrate measurement models from an old process to a new “similar” process. In this approach, the authors first define “similarity” of two processes mathematically and then use it to give a first estimate of the measurement uncertainty of the similar measurement process and develop different learning strategies. A trained machine-learning model is then migrated to a similar measurement process without having to perform an equal size of experiments.Similarity assessment and model migration

Findings

The authors’ findings show that the proposed similarity assessment and model migration strategy can be used for reducing the effort for measurement uncertainty determination. They show that their method can be applied to a real pair of similar measurement processes, i.e. two computed tomography scans. It can be shown that, when applying the proposed method, a valid estimation of uncertainty and valid model even when using less data, i.e. less effort, can be built.

Originality/value

The proposed strategy can be applied to any two measurement processes showing a particular “similarity” and thus reduces the effort in estimating measurement uncertainties and finding valid measurement models.
COVID-19-induced shopping behavioural shifts justifying pandemic as ‘defining moment’ for generation Z
Authors: Agrawal Durgesh Kumar
Published: February 2023

Purpose

COVID-19 pandemic endured for more than two years in many countries which caused higher levels of risk, crisis and vulnerability among people. The present study aims at justifying the COVID-19 pandemic as the ‘defining moment’ for Z generational cohort (Gen Z) by examining their post-COVID-19 shopping behavioural shifts.

Design/methodology/approach

For this purpose, two studies were conducted. Study 1 examined shifts in their shopping priorities from the pre to post-pandemic eras by using mean, standard deviation and differencet-tests. Study 2 investigated the role of the 18 items in their post-COVID-19 online shopping preference and the results were compared with a similar pre-COVID-19 study to identify online shopping behavioural shifts.

Findings

The study finds five key post-COVID-19 shopping behavioural shifts among Gen Z consumers. These are ‘an inevitable inner desire for mitigating social isolation, risk and vulnerability’, ‘rational purchase decisions based on an in-depth analysis of multiple digital contents related to products/brands’, ‘permanent frugality in the shopping habits’, ‘conscious and cautious consumption’ and ‘the sacrifice of personal grit, idealism and psychology’.

Practical implications

Since the post-COVID-19 shopping behavioural shifts have far-reaching implications and long-lasting effects on the psychological processes and mental health of Gen Z, marketers/retailers can use the findings of this study to develop more effective marketing strategies for serving these early-adulthood consumers better.

Originality/value

Based on their metamorphic shopping behavioural shifts by comparing their pre-pandemic and post-pandemic responses, the study justifies the severity and devastating effects of the pandemic crisis as the ‘defining moment’ for the youths of this COVID-19 generation.
Financial inclusion through FinTech and women's financial empowerment
Authors: Esmaeilpour Moghadam Hadi , Karami Arezou
Published: February 2023

Purpose

Women's financial empowerment (WFE) is one of the sustainable development goals. This research examines the effect of financial inclusion through FinTech (FIF) on WFE at the international level. The purpose of this paper is to address this issue.

Design/methodology/approach

The authors analyze the dataset of 113 countries from the Global Findex (2017) and World Bank databases using principal component analysis (PCA) and cross-sectional data methodology. Initially, they calculate the overall index for FIF with PCA. Then, they investigate the effect of FIF on WFE in two groups of countries classified by low and high levels of gender discrimination.

Findings

The results show that the relationship between FIF and WFE is positive and significant in countries classified by low levels of gender discrimination. However, this effect is insignificant in countries with high gender discrimination. Hence, gender inequality is a barrier and denies financial independence to women.

Research limitations/implications

Given these results, it seems unlikely that FinTech will be able to eliminate the gender gap in financial inclusion on its own for women's empowerment. To directly address the gender gap and alter attitudes and social norms across demographics, FinTech development may need to be supplemented with focused policy initiatives.

Originality/value

This study provides evidence of FIF's impact on WFE at the international level.
Industrialisation, ecologicalisation and digitalisation (IED): building a theoretical framework for sustainable development
Authors: Shi Yongjiang , Hu Jialun , Shang David Tianxin , Liu Zheng , Zhang Wei
Published: February 2023

Purpose

In the past two decades, manufacturing has witnessed significant transformations alongside ecological challenges. Meanwhile, industrial 4.0 digital technologies have accelerated industrialisation with potentials of innovation in the context of circular economy. However, current concepts and models are fragmented and impractical. This paper aims to develop a holistic view integrating the three bodies of knowledge – industrialisation, ecologicalisation and digitalisation (IED) – in order to achieve sustainable development.

Design/methodology/approach

Critical literature review is conducted across three bodies of knowledge. Key themes are summarised with the identification of research gaps. A theoretical framework is synthesised and developed aiming to achieve synergy from IED with the modules, integration architecture, mechanism and dynamic paths.

Findings

First, the authors review and develop three conceptual models of ecologicalised industrialisation (IE3), industrial system digitalisation (D1) and digital technology industrialisation (D2) separately. Second, the authors propose a theoretical framework seeking to synthesise the above three conceptual models together to form the IED. Third, the authors design a process orientated abductive approach to improve and validate the IED framework.

Originality/value

This study contributes to the limited literature addressing the linkage of IED by integration different perspectives to develop theory in a novel way. Practically, it provides important tools for organisations to consider resource cascading in combination with digitalisation during the industrial system design.
Internationalized knowledge-intensive business service (KIBS) for servitization: a microfoundation perspective
Authors: Magni Domitilla , Papa Armando , Scuotto Veronica , Del Giudice Manlio
Published: February 2023

Purpose

A paucity of studies has used a microfoundation lens to examine servitization processes in internationalized knowledge-intensive business service (KIBS) companies. The research aims to bridge this gap by considering knowledge sharing as a form of both codified knowledge and informal feedback knowledge; it also assesses whether the adoption of knowledge transfer and translation practices in a servitization process positively moderates the effect of knowledge transformation on knowledge sharing for internationalized KIBS companies.

Design/methodology/approach

By adopting a microfoundation lens, the research offers an empirical analysis to identify the relations between codified and tacit knowledge in servitization processes within internationalized KIBS companies. The study is based on 326 respondents from 30 KIBS companies. A multiple regression analysis was used for hypotheses testing.

Findings

The authors found significant relations among the use of electronic documents in the servitization process (formal codified knowledge), personal advice in servitization (informal feedback knowledge) and knowledge sharing in internationalized KIBS companies. Findings also support the indirect effect assumed in the hypothesis between knowledge transformation and knowledge sharing in internationalized KIBS companies, which is positively moderated by the adoption of cross-cultural knowledge practices in the servitization process.

Originality/value

To the best of the authors’ knowledge, this research provides the first conceptual model of the use of a microfoundation lens to examine knowledge sharing in internationalized KIBS companies. The micro level features individual knowledge sharing in the servitization process, while the meso level focuses on knowledge transformation in KIBS companies and the adoption of knowledge transfer and translation practices in the servitization process.
The influence of sense of place dimensions on visitors' conservation behavioral intention: the case of Semarang Old Town, Indonesia
Authors: Dameria Christin , Winarso Haryo , Indradjati Petrus Natalivan , Tjokropandojo Dewi Sawitri
Published: February 2023

Purpose

The purpose of the study is to confirm the influence of each dimension of visitor's sense of place (place identity, place attachment and place dependence) on each dimension of conservation behavioral intention (general behavioral intention and specific behavioral intention) in the context of urban heritage.

Design/methodology/approach

This study uses a quantitative methods. Research respondent is individual visitor who meet the research criteria. The strength influence of sense of place dimension (independent variable) on dimension of conservation behavioral intention (dependent variable) was measured by Somers' D correlation. Primary data were analyzed using descriptive statistical techniques.

Findings

All correlation coefficient values were below +0.59. It shows that the sense of place dimensions have a weak influence on each dimension of conservation behavioral intention. Weak correlation occurs because of the setting profile (tourism approaches which tends to be material-based) and the type of visitor (casual cultural tourism and sightseeing tourist) which interprets heritage only as an object of relaxation.

Research limitations/implications

Due to the statistical approach used (nonparametric statistical techniques), the results of the study cannot be generalized. Therefore, further studies with different approaches are needed.

Social implications

This study demonstrates the need for tourism policy in Semarang Old Town (SOT) as a form of value-driven heritage conservation practice to encourage visitors to appreciate the cultural significance of the area.

Originality/value

In the context of urban heritage area, the literature on research topics is still limited. However, the results of this study were different from previous studies. The weak relationship is explained through an approach that considers contextual factors, namely profile settings and visitor profiles.
Effects of grazing on soil nematodes in grasslands: A global meta‐analysis
Authors: Zhou Juan , Xiang Yangzhou , Sheng Xiongjie , Wu Jianping
Published: February 2023

Grazing contributes substantially to grassland degradation worldwide and may alter soil biota and function. However, the effects of grassland type, grazing intensity and duration, and livestock type on soil nematodes are not fully understood.

Here, we compiled 783 pair‐wise comparisons from 28 publications to better understand the pattern and underlying mechanisms of soil nematodes responses to grazing.

Grazing significantly decreased the abundance of bacterial‐feeding and omnivorous‐predatory nematodes but had no effect on diversity (e.g. generic richness) and ecological indices (e.g. maturity index and plant‐parasitic index). Grazing effects on soil nematodes varied strongly by grassland type, grazing intensity and duration, and livestock type. Grazing decreased bacterial‐feeding nematodes in steppe. In meadow, grazing increased plant‐feeding nematodes and reduced nematode diversity. The abundance of bacterial‐feeding and fungal‐feeding nematodes significantly decreased in long‐term grazing (>10 years). Light grazing increased fungal‐feeding nematodes and maturity index. Heavy grazing decreased total nematode abundance, the abundance of all trophic groups except plant‐feeding nematodes and the enrichment index. Sheep grazing produced a stronger negative response than cattle grazing on the abundance of bacterial‐feeding and omnivorous‐predatory nematodes, Shannon–Wiener index and enrichment index. Environment factors and soil properties influenced the grazing effects on nematode abundance. Our results showed that the grazing effects on nematode abundance were well explained by pH and soil organic carbon.

Synthesis and applications. Our findings highlight that grazing effects on soil nematodes are context‐specific. As the contribution of soil nematodes to grassland management and ecosystem functions, we propose that policymakers should consider devising local‐scale grazing strategies for conserving soil biota and the functions of soil food webs.
Metabolomics profiling of seminal plasma in obesity‐induced asthenozoospermia
Authors: Zhou Yan‐fen , Hou Yu‐yang , Ban Qian , Zhang Meng‐ling , Huang Tao , Ma Bo , Shi Liang , Zhang Qi
Published: February 2023

Background

Asthenozoospermia is one of the essential causes of male infertility, and its incidence is significantly higher in obese men. Due to its complex etiology and unknown pathomechanism, the diagnosis and treatment of obesity‐induced asthenozoospermia is a prevalent problem in reproductive medicine.

Objective

This study aims to explore major differential metabolites and metabolic pathways in seminal plasma and pathological mechanisms for obesity‐induced asthenozoospermia.

Materials and Methods

We performed non‐target metabolomic studies on the seminal plasma of healthy men with normal semen parameters (HN group, n = 20), obese men with normal semen parameters (ON group, n = 20), and men with obesity‐induced asthenozoospermia (OA group, n = 20) based on gas chromatography‐mass spectrometry. Metabolic profilings and related pathway analyses were conducted to discriminate differential metabolites and metabolic pathways.

Results

A total of 20 differential metabolites including fructose, succinic acid, aconitic acid, methylmaleic acid, glucopyranose, serine, valine, leucine, phenylalanine, glycine, glutamic acid, alanine, proline and threonine were identified in HN group and ON group; 24 differential metabolites including glucose, fructose, pyruvic acid, citric acid, succinic acid, aconitic acid, glucopyranose, glutamic acid, valine, leucine, glycine, phenylalanine, lysine, citrulline, proline and alanine were produced in OA group and ON group; and 28 differential metabolites including glucose, fructose, citric acid, succinic acid, glucopyranose, valine, glycine, serine, leucine, phenylalanine, alanine, threonine, proline, glutamic acid, citrulline, lysine and tyrosine were produced in OA group and HN group. In addition, abnormal energy metabolism including carbohydrate metabolism (TCA cycle, glycolysis/gluconeogenesis, and pyruvate metabolism) and amino acid metabolism (phenylalanine, tyrosine, and tryptophan biosynthesis, D‐glutamine and D‐glutamate metabolism; phenylalanine metabolism, etc.) were found in ON group and OA group.

Conclusion

Obesity could affect the metabolite composition in seminal plasma and abnormal energy metabolism in seminal plasma mainly including carbohydrate metabolism and amino acid metabolism were closely related to obesity‐induced asthenozoospermia.
A multicriteria model to support the selection of inspection service providers based on the delay time model
Authors: Rodrigues Augusto José da Silva , Cavalcante Cristiano Alexandre Virgínio , Alberti Alexandre Ramalho
Published: February 2023

This paper proposes a multicriteria model based on the delay time concept and the FITradeoff method to support the choice of a service provider who inspects isolation valves, thereby enabling maintenance actions that have a strategic focus to be established for natural gas industries. We consider the possibility of errors of judgment (false negatives), thus allowing an approximation of reality to be made. In addition, the FITradeoff method is used to enable a decision‐maker to aggregate his/her preferences by taking account of more than one criterion simultaneously, even though the criteria generally conflict with each other. Furthermore, we undertake a numerical application to assess the practical implications. The model proved to be effective at supporting decision‐makers to select companies to provide periodic inspection services, which are often carried out under contracts. We have also evaluated how maintenance decisions change due to different decision‐makers' standards so as to obtain more appropriate procedures for maintenance actions. This has an impact on reducing the occurrence of failures and, consequently, reducing risks to people who live near the gas pipelines.
Attitudes and self‐efficacy towards infection prevention and control and antibiotic stewardship among nurses: A mixed‐methods study
Authors: Tangeraas Hansen Marte Johanne , Storm Marianne , Syre Heidi , Dalen Ingvild , Husebø Anne Marie Lunde
Published: February 2023

Aims

To gain a comprehensive understanding of nurses' infection control practices, antibiotics stewardship attitudes and self‐efficacy when caring for patients with multidrug‐resistant bacterial infections in a hospital setting.

Background

Multidrug‐resistant bacteria cause a substantial health burden by complicating infections and prolonging hospital stays. Attitudes and self‐efficacy can inform professional behaviour. Nurses' attitudes and self‐efficacy concerning multidrug‐resistant bacteria, infection prevention and control and antibiotic stewardship are vital in keeping patients safe.

Design

A descriptive and convergent mixed‐methods design involving quantitative and qualitative approaches was used.

Methods

Two hundred and seventeen nurses working in clinical practice at seven different hospital wards (i.e., general medicine, surgical, haematological and oncology) at a Norwegian university hospital were invited to participate. Data were collected in February and March 2020 via two questionnaires: the Multidrug‐Resistant Bacteria Attitude Questionnaire and the General Perceived Self‐Efficacy Scale (n = 131) and four focus group interviews (n = 22). The data were analysed using descriptive statistics and systematic text condensation.

Results

Most nurses showed moderate knowledge, adequate behavioural intentions towards infection prevention and antibiotic stewardship, and high self‐efficacy. However, they reported negative emotions towards their knowledge level and negative emotions towards nursing care. The nurses appeared uncertain about their professional influence and role in antibiotic stewardship practices. Organisational and relational challenges and ambivalent perceptions of nurses' role were potential explanations.

Conclusion

Nurses report moderate attitudes and high self‐efficacy when caring for patients with multidrug‐resistant bacterial infections. This study suggests that nurses experience organisational and relational factors in their work environment that challenge their attitudes towards infection prevention and control and antibiotic stewardship practices. Measures that strengthen their knowledge and emotional response underpin correct infection prevention and control behaviour. A role clarification is needed for antibiotic stewardship.

No Patient or Public Contribution.

Relevance to clinical practice

Measures to increase attitudes towards infection prevention and control, antibiotic stewardship and multidrug resistance is recommended. Measures should be taken to overcome organisational challenges. A clarification of the nurses' role in antibiotic stewardship is needed.
Stigma toward internalizing and externalizing disorders: How do adolescents perceive their peers? A network analysis approach
Authors: Mannarini Stefania , Taccini Federica , Rossi Alessandro Alberto
Published: February 2023

This study's first aim was to explore whether stigma's facets differ between internalizing and externalizing disorders in adolescence. The second aim was to compare the relationships among stigma's facets toward these disorders. Two vignettes depicting a peer with Major Depressive Disorder (MDD) or Attention‐Deficit Hyperactivity Disorder (ADHD) were used with 616 adolescents in Italy. A Repeated measure MANOVA showed biogenetic causes, social distancing, and discomfort were more attributed to depression, while dangerousness to ADHD. Furthermore, a Psychometric Network Analysis showed no differences between these disorders in the relations among stigma's components. However, dangerousness seemed to be among the nodes with the highest levels of “strength,” confirming previous literature that shows that dangerousness plays a major role in stigma.
Impact of early memories and current experiences of warmth and safeness on adolescents' psychological distress
Authors: Santos Laura , Ribeiro da Silva Diana , Pinheiro Maria do Rosário , Rijo Daniel
Published: February 2023

A variable‐centered and a person‐centered approach were performed to examine the role of early memories of warmth and safeness (EMWS) and current experiences of warmth and safeness (CEWS) on depressive and anxious symptoms among adolescents from community and residential youth care (RYC) settings. Variable‐centered results revealed EMWS were only indirectly (through CEWS) associated with depressive and anxious symptoms. Person‐centered outcomes allowed to identify four different profiles based on EMWS and CEWS, which differed on depressive and anxious symptoms. EMWS and CEWS seem to play an important role in psychological distress during adolescence. CEWS seem to have a protective role on RYC adolescents' psychological distress, even when EMWS were poor.
Recovery and curation of the Winchcombe (CM2) meteorite
Authors: Russell Sara S. , King Ashley J. , Bates Helena C. , Almeida Natasha V. , Greenwood Richard C. , Daly Luke , Joy Katherine H. , Rowe Jim , Salge Tobias , Smith Caroline L. , Grindrod P. , Boazman S. , Bond L. , Bond V. , Casey C. , Dickeson Z. , Ensor G. , Farrelly S. , Godfrey P. , Hallis L. J. , Ihász M. B. , Kirk D. , Jackson L. , Lee M. R. , Mayne B. , McMullan S. , Mounsey A. , Mounsey S. E. , Mounsey S. , Motaghian S. , Naqvi S. , O'Brien Á. , Pickersgill A. , Skilton D. , Spencer I. , Stephen N. R. , Suttle F. , Suttle M. D. , Tartese R. , Weir C. , Wilcock Cathryn , Wilcock Hannah , Wilcock Rob
Published: February 2023

The Winchcombe meteorite fell on February 28, 2021 and was the first recovered meteorite fall in the UK for 30 years, and the first UK carbonaceous chondrite. The meteorite was widely observed by meteor camera networks, doorbell cameras, and eyewitnesses, and 213.5 g (around 35% of the final recovered mass) was collected quickly—within 12 h—of its fall. It, therefore, represents an opportunity to study very pristine extra‐terrestrial material and requires appropriate careful curation. The meteorite fell in a narrow (600 m across) strewn field ~8.5 km long and oriented approximately east–west, with the largest single fragment at the farthest (east) end in the town of Winchcombe, Gloucestershire. Of the total known mass of 602 g, around 525 g is curated at the Natural History Museum, London. A sample analysis plan was devised within a month of the fall to enable scientists in the UK and beyond to quickly access and analyze fresh material. The sample is stored long term in a nitrogen atmosphere glove box. Preliminary macroscopic and electron microscopic examinations show it to be a CM2 chondrite, and despite an early search, no fragile minerals, such as halite, sulfur, etc., were observed.
Sub‐arctic mosses and lichens show idiosyncratic responses to combinations of winter heatwaves, freezing and nitrogen deposition
Authors: Bokhorst Stef , Bjerke Jarle W. , Phoenix Gareth K. , Jaakola Laura , Mæhre Hanne K. , Tømmervik Hans
Published: February 2023

Arctic ecosystems are increasingly exposed to extreme climatic events throughout the year, which can affect species performance. Cryptogams (bryophytes and lichens) provide important ecosystem services in polar ecosystems but may be physiologically affected or killed by extreme events. Through field and laboratory manipulations, we compared physiological responses of seven dominant sub‐Arctic cryptogams (three bryophytes, four lichens) to single events and factorial combinations of mid‐winter heatwave (6°C for 7 days), re‐freezing, snow removal and summer nitrogen addition. We aimed to identify which mosses and lichens are vulnerable to these abiotic extremes and if combinations would exacerbate physiological responses. Combinations of extremes resulted in stronger species responses but included idiosyncratic species‐specific responses. Species that remained dormant during winter (March), irrespective of extremes, showed little physiological response during summer (August). However, winter physiological activity, and response to winter extremes, was not consistently associated with summer physiological impacts. Winter extremes affect cryptogam physiology, but summer responses appear mild, and lichens affect the photobiont more than the mycobiont. Accounting for Arctic cryptogam response to multiple climatic extremes in ecosystem functioning and modelling will require a better understanding of their winter eco‐physiology and repair capabilities.
Characterization of the novel HLA‐C*05:01:01:81Q allele by sequencing‐based typing
Authors: Cargou Marine , Elsermans Vincent , Raclet Virginie , Wojciechowski Elodie , Visentin Jonathan
Published: February 2023

HLA‐C*05:01:01:81Q differs from HLA‐C*05:01:01:02 by one nucleotide substitution in position 202 in intron 1 (c.74‐2A>G, hg19).