bluuebunny/crossref_metadata_2025 huggingface dataset:
Temporal diabetes- and diuresis-induced remodeling of the urinary bladder in the rat
Authors: Liu Guiming , Daneshgari Firouz
Published: March 2006

The natural history of diabetes mellitus-induced remodeling of the urinary bladder is poorly understood. In this study, we examined temporal remodeling of the bladder in diabetic and diuretic rats. Male Sprague-Dawley rats were divided into three groups: streptozotocin-induced diabetic, 5% sucrose-induced diuretic, and age-matched control. Micturition and morphometric characteristics were evaluated using metabolic cages and light-microscopic examination of the bladder 4 days and 1, 2, 3, and 9 wk after induction. Digital image analysis was used to quantify equatorial cross-sectional areas of bladder tissue and lumen, as well as relative content of the three primary tissue components: smooth muscle, urothelium, and collagen. Diabetes and diuresis caused significant increases in fluid intake, urine output, and bladder weight. In both groups, progressive increases were observed in lumen area from 4 days to 3 wk after induction and in wall area from 2 to 3 wk after induction. Wall thickness decreased within the first 2 wk in the diabetic and diuretic rats but returned to control at 3 and 9 wk. As a percentage of total cross-sectional area, smooth muscle area increased, urothelium area was unchanged, and collagen area decreased in diabetic and diuretic rats after 2–3 wk compared with control rats. In conclusion, diabetes and diuresis induced similar bladder remodeling. Diabetes-induced diuresis caused adaptive physical changes in rat bladder by 4 days after induction; remodeling was observed by 2–3 wk after induction and remained stable from 3 to 9 wk.
Effect of acute increases in pulmonary vascular pressures on exercise pulmonary gas exchange
Authors: Stickland Michael K. , Welsh Robert C. , Haykowsky Mark J. , Petersen Stewart R. , Anderson William D. , Taylor Dylan A. , Bouffard Marcel , Jones Richard L.
Published: March 2006

The purpose of this study was to determine the effect of acute increases in pulmonary vascular pressures, caused by the application of lower-body positive pressure (LBPP), on exercise alveolar-to-arterial Po2 difference (A-aDo2), anatomical intrapulmonary (IP) shunt recruitment, and ventilation. Eight healthy men performed graded upright cycling to 90% maximal oxygen uptake under normal conditions and with 52 Torr (1 psi) of LBPP. Pulmonary arterial (PAP) and pulmonary artery wedge pressures (PAWP) were measured with a Swan-Ganz catheter. Arterial blood samples were obtained from a radial artery catheter, cardiac output was calculated by the direct Fick method, and anatomical IP shunt was determined by administering agitated saline during continuous two-dimensional echocardiography. LBPP increased both PAP and PAWP while upright at rest, and at all points during exercise (mean increase in PAP and PAWP 3.7 and 4.0 mmHg, respectively, P < 0.05). There were no differences in exercise oxygen uptake or cardiac output between control and LBPP. Despite the increased PAP and PAWP with LBPP, A-aDo2 was not affected. In the upright resting position, there was no evidence of shunt in the control condition, whereas LBPP caused shunt in one subject. At the lowest exercise workload (75 W), shunt occurred in three subjects during control and in four subjects with LBPP. LBPP did not affect IP shunt recruitment during subsequent higher workloads. Minute ventilation and arterial Pco2 were not consistently affected by LBPP. Therefore, small acute increases in pulmonary vascular pressures do not widen exercise A-aDo2 or consistently affect IP shunt recruitment or ventilation.
Classical Conditioning as the Basis for the Effective Treatment of Tinnitus-Related Distress
Authors: Wilson Peter H.
Published: March 2006

In this paper the history of the emergence of psychological treatments based on the scientist-practitioner model, such as cognitive-behavior therapy, is described. This historical perspective serves to highlight the potential underlying theoretical bases of such approaches. It is argued that the behavioral position need not be abandoned in order to justify the use of so-called cognitive approaches. Indeed, the behaviorist position, far from having outlived its usefulness, remains an important explanatory concept of human behavior and emotion. This theoretical position may also hold the key to identifying features which are shared in common by tinnitus retraining therapy and cognitive-behavior therapy, and which might be responsible for the efficacy of these approaches. Studies are required in which the basic mechanisms responsible for individual responses to tinnitus are identified in order to develop better approaches to assist people to cope with tinnitus.
Joint Medico-Psychological Consultation for Patients Suffering from Tinnitus
Authors: Degive Colette , Kos Maria-Izabel
Published: March 2006

Because no effective treatment against tinnitus is available, all sorts of approaches have been developed. We believe the care of tinnitus patients concerns mainly ENT medical doctors. In order to take care of such patients, we started in 1993 a joint medico-psychological consultation (JMPC) to dispense adequate care for patients and training to the ENT residents. Every patient visiting our clinic for a tinnitus consultation benefits first from a comprehensive audiological examination. Once all objective causes of tinnitus are excluded, those patients who were not able to accept their auditory disorder or who insist on focusing on the annoyance caused by the perception of their tinnitus are invited by the doctor to the JMPC. The intolerance caused by tinnitus is enhanced by psychological and social aspects. These aspects are considered and discussed during the JMPC. The patients talk about their tinnitus bringing additional information on professional, familial and relational issues. In the JMPC, the therapists try to help the patients to void the affective irritation and the internal tension they clearly demonstrate. When the patients notice that the therapists accept their distress, they usually talk more calmly about their hearing irritation and even consider it tolerable. The medical and psychological information given during the JMPC helps the patients to understand the links between tinnitus and the disturbing elements of their current life. During the JMPC, the medical residents have been able to observe how somatic complaints can lead to complaints of another nature, to distress, to aggressive or angered behaviors. They have acknowledged the way the psychologist deals with the attitudes of these patients. This learning process became mandatory to all our residents specializing in ENT. At the end of their training they should have learned how to help the patient accept the tinnitus and the irritation it causes. They should be able to help tinnitus patients to stop searching for a treatment that does not exist in the so-called specialized centers, which often do not fulfill their expectations.
Typewriter Tinnitus: A Carbamazepine-Responsive Syndrome Related to Auditory Nerve Vascular Compression
Authors: Levine Robert Aaron
Published: March 2006

Six subjects with similar unilateral tinnitus that was fully suppressed by carbamazepine have been identified. Their ages at the time of the sudden onset of their tinnitus ranged from 39 to 87 years (mean 67). The 3 men had right ear tinnitus. Two of the 3 women had left ear tinnitus. All 6 described a staccato quality of their intermittent tinnitus (‘like a typewriter in the background, pop corn, Morse code’). Five of the 6 subjects had no other hearing or vestibular complaints; their audiograms were symmetric and consistent with their ages. Vascular compression of the auditory nerve ipsilateral to the tinnitus was detected in 4 of the 5 subjects imaged. The similarities between typewriter tinnitus and other cranial nerve syndromes associated with vascular compression (trigeminal neuralgia, hemifacial spasm, and glossopharyngeal neuralgia) suggest that surgical decompression of the auditory nerve can relieve medication-refractive cases of typewriter tinnitus.
Quantification of the Power of Hardy-Weinberg Equilibrium Testing to Detect Genotyping Error
Authors: Cox David G. , Kraft Peter
Published: March 2006

Deviation from Hardy-Weinberg equilibrium has become an accepted test for genotyping error. While it is generally considered that testing departures from Hardy-Weinberg equilibrium to detect genotyping error is not sensitive, little has been done to quantify this sensitivity. Therefore, we have examined various models of genotyping error, including error caused by neighboring SNPs that degrade the performance of genotyping assays. We then calculated the power of chi-square goodness-of-fit tests for deviation from Hardy-Weinberg equilibrium to detect such error. We have also examined the affects of neighboring SNPs on risk estimates in the setting of case-control association studies. We modeled the power of departure from Hardy-Weinberg equilibrium as a test to detect genotyping error and quantified the effect of genotyping error on disease risk estimates. Generally, genotyping error does not generate sufficient deviation from Hardy-Weinberg equilibrium to be detected. As expected, genotyping error due to neighboring SNPs attenuates risk estimates, often drastically. For the moment, the most widely accepted method of detecting genotyping error is to confirm genotypes by sequencing and/or genotyping via a separate method. While these methods are fairly reliable, they are also costly and time consuming.
Wittgenstein’s Philosophy and a Dimensional Approach to the Classification of Mental Disorders – A Preliminary Scheme
Authors: Mackinejad Kioumars , Sharifi Vandad
Published: March 2006

In this paper the importance of Wittgenstein’s philosophical ideas for the justification of a dimensional approach to the classification of mental disorders is discussed. Some of his basic concepts in his Philosophical Investigations, such as ‘family resemblances’, ‘grammar’ and ‘language-game’ and their relations to the concept of mental disorder are explored.
Measuring Adult Attachment Representation in an fMRI Environment: Concepts and Assessment
Authors: Buchheim Anna , George Carol , Kächele Horst , Erk Susanne , Walter Henrik
Published: March 2006

Human attachment is defined as a biologically based behavioral system that influences motivational, cognitive, emotional, and memory processes with respect to intimate relationships (parents, life partner, own children). Recent neurobiological studies in this field have in common that they investigated social relationships by examining fMRI neuroimaging patterns while individuals viewed pictures of their beloved relationship partner versus friends, acquaintances, strangers, or mothers’ responses to their young children. The researchers showed that the neural underpinnings of these unique intimate emotional states are linked to functionally specialized areas in the brain. Conceptualizing this work from a behavioral systems-attachment theory perspective, these studies did not directly address the subject’s attachment representational system. Traditional attachment theory and research has been built on the analysis of attachment narratives, called ‘attachment representation’. The Adult Attachment Projective developed by George and West in 2001 is a set of attachment-based schematic pictures. It is constructed to increasingly activate the participant’s attachment system in the course of the task, that is, by the introduction of increasingly stressful attachment scenes concluding with pictures of individuals facing death and potential abuse alone. The attachment patterns are evaluated based on individuals’ overall verbal response to the picture set. This paper proposes that the AAP is a fruitful measure to use in an fMRI environment to examine brain activation patterns in adults while they are speaking overtly about attachment stories in a standardized setting.
Serum Creatine Kinase Activity Varies with Ovulatory Status in Regularly Exercising, Premenopausal Women
Authors: Thompson Heather S. , Scordilis Stylianos P. , De Souza Mary Jane
Published: March 2006

Background/Aims: The clinical complications associated with an unopposed estrogen environment and luteal phase defects observed in exercising women prompted the examination of the relationship of exercise and endogenous ovarian steroids with serum creatine kinase (CK) activity. Methods: Subjects (n = 34) were classified into three groups according to their exercise and menstrual status, sedentary and exercising ovulatory groups (SedOvul, ExOvul), and an exercising amenorrheic group (ExAmen). Daily urine samples were collected to assess urinary ovarian steroid exposure and menstrual status. Serum CK activity was assayed in each menstrual cycle of all subjects. Results: Exercise increased serum CK activity in all exercising subjects (p < 0.01), but the increase was greater in amenorrheic women compared to ovulatory women (SedOvul: 33.0 ± 3.4; ExOvul: 43.7 ± 4.1; ExAmen: 54.4 ± 3.6, p < 0.05). When the ovulatory women were further divided into those with normal steroid production (ExOvul subgroup) and those with a suppressed progesterone luteal phase environment (ExLPD), both the ExOvul (51.9 ± 5.4 IU/l) subgroup and ExAmen group had higher serum CK activity (p < 0.05) than the ExLPD (36.6 ± 5.2 IU/l) subjects or the sedentary controls. Conclusions: These data demonstrate the complex association between ovarian hormone status and the normal serum CK response to regular mechanical stress imposed by chronic exercise training.
Evaluation of Factor V Leiden, Prothrombin and Methylenetetrahydrofolate Reductase Gene Mutations in Patients with Severe Pregnancy Complications in Northern Finland
Authors: Jarvenpaa J. , Pakkila M. , Savolainen E.-R. , Perheentupa A. , Jarvela I. , Ryynanen M.
Published: March 2006

Background: Thrombosis in placenta may lead to severe pregnancy complications. Most important inherited thrombophilias are factor V Leiden mutation, prothrombin mutation, and methylenetetrahydrofolate reductase mutation. The aim of our research was to evaluate the prevalence of inherited thrombophilias in severe pregnancy complications and in normal pregnancies. Material and Methods: The study subjects with severe preeclampsia, intrauterine growth restriction, placental abruption or fetal death were collected during the period 1999–2004 from Oulu University Hospital. We also collected during the same period voluntary parturients with normal pregnancy outcome as the control group. FVL, FII, and MTHFR gene mutations of the patients and controls were analyzed. Results: We found a significant difference in the prevalence of FVL mutation between the groups. There were 9.5% FVL mutations in the study group compared to 1.8% in the control group; the observed difference between prevalences was 7.7% (95% CI 2.0–13.4). No statistical difference was found in the FII or MTHFR mutations between the groups. All FV and FII mutations were heterozygous and all the MTHFR mutations homozygous. Conclusion: Women with thrombophilia have a risk for severe pregnancy complications. Randomized controlled trials are needed to assess the influence of low-molecular-weight heparin in pregnant women with thrombophilia.
Plasminogen Activator Inhibitor-1 From Bone Marrow–Derived Cells Suppresses Neointimal Formation After Vascular Injury in Mice
Authors: Schäfer Katrin , Schroeter Marco R. , Dellas Claudia , Puls Miriam , Nitsche Mirko , Weiss Elisabeth , Hasenfuss Gerd , Konstantinides Stavros V.
Published: March 2006

Objective—

To investigate the ability of bone marrow (BM)–derived cells to modulate neointimal growth after injury by expressing plasminogen activator inhibitor-1 (PAI-1).

Methods and Results—

We performed BM transplantation (BMT) in lethally irradiated wild-type (WT) and PAI-1−/− mice. Three weeks after carotid injury with ferric chloride, analysis of Y-chromosome DNA expression in the vessel wall of female hosts revealed that 20.8±6.0% of the cells in the neointima and 37.6±5.7% of those in the media were of BM origin. Lack of PAI-1 in either the host or the donor cells did not affect recruitment of BM-derived cells into sites of vascular injury. The neointima consisted predominantly of smooth muscle cells, and a proportion of these cells expressed PAI-1. Overall, lack of PAI-1 was associated with enhanced neointimal formation. However, importantly, BMT
WT→PAI-1−/−
mice exhibited reduced neointimal area (
P
=0.05) and luminal stenosis (
P
=0.04) compared with BMT
PAI-1−/−→PAI-1−/−
mice. Although PAI-1–expressing cells were shown to be present in BMT
WT→PAI-1−/−
lesions, these mice did not exhibit detectable levels of the inhibitor in the circulation, suggesting that local production of PAI-1 by cells in the neointima and media was sufficient to reduce luminal stenosis.

Conclusions—

PAI-1 from BM-derived cells appears capable of suppressing neointimal growth after vascular injury.
Role of Nuclear Ca
2+
/Calmodulin-Stimulated Phosphodiesterase 1A in Vascular Smooth Muscle Cell Growth and Survival
Authors: Nagel David J. , Aizawa Toru , Jeon Kye-Im , Liu Weimin , Mohan Amy , Wei Heng , Miano Joseph M. , Florio Vincent A. , Gao Pingjin , Korshunov Vyacheslav A. , Berk Bradford C. , Yan Chen
Published: March 2006

In response to biological and mechanical injury, or in vitro culturing, vascular smooth muscle cells (VSMCs) undergo phenotypic modulation from a differentiated “contractile” phenotype to a dedifferentiated “synthetic” one. This results in the capacity to proliferate, migrate, and produce extracellular matrix proteins, thus contributing to neointimal formation. Cyclic nucleotide phosphodiesterases (PDEs), by hydrolyzing cAMP or cGMP, are critical in the homeostasis of cyclic nucleotides that regulate VSMC growth. Here, we demonstrate that PDE1A, a Ca
2+
-calmodulin–stimulated PDE preferentially hydrolyzing cGMP, is predominantly cytoplasmic in medial “contractile” VSMCs but is nuclear in neointimal “synthetic” VSMCs. Using primary VSMCs, we show that cytoplasmic and nuclear PDE1A were associated with a contractile marker (SM-calponin) and a growth marker (Ki-67), respectively. This suggests that cytoplasmic PDE1A is associated with the “contractile” phenotype, whereas nuclear PDE1A is with the “synthetic” phenotype. To determine the role of nuclear PDE1A, we examined the effects loss-of-PDE1A function on subcultured VSMC growth and survival using PDE1A RNA interference and pharmacological inhibition. Reducing PDE1A function significantly attenuated VSMC growth by decreasing proliferation via G
1
arrest and inducing apoptosis. Inhibiting PDE1A also led to intracellular cGMP elevation, p27
Kip1
upregulation, cyclin D1 downregulation, and p53 activation. We further demonstrated that in subcultured VSMCs redifferentiated by growth on collagen gels, cytoplasmic PDE1A regulates myosin light chain phosphorylation with little effect on apoptosis, whereas inhibiting nuclear PDE1A has the opposite effects. These suggest that nuclear PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis.
Differential Regulation of Endothelial Cell Activation by Complement and Interleukin 1α
Authors: Brunn Gregory J. , Saadi Soheyla , Platt Jeffrey L.
Published: March 2006

Activation of complement on endothelium triggers physiological changes that promote coagulation, thrombosis, and inflammation. Unlike agonists such as cytokines and endotoxin that induce these changes through transcription of many genes, complement, particularly the membrane attack complex, primarily induces release of IL-1α by the endothelial cells; the cytokine may then be removed by normal blood flow or may promote activation of the full range of endothelial cell responses in an autocrine or paracrine manner. We studied the intracellular signaling pathways used by complement to activate interleukin (IL)-1α transcription in cultured endothelial cells. The membrane attack complex and other pore-forming proteins stimulated calcineurin and activated selective transcription of the IL-1α gene. In contrast, the action of cytokines such as IL-1α was not selective and not dependent on calcineurin activity. Transcription of IL-1α, whether stimulated by complement and calcineurin or by “conventional agonists,” such as IL-1α independent of calcineurin, proceeded via binding of nuclear factor κB transcriptional activators to the IL-1α gene promoter. These findings define a molecular mechanism through which complement regulates IL-1α production by endothelial cells and explain how blood flow may determine the extent of complement-stimulated inflammation.
Temporal Profile of Recanalization After Intravenous Tissue Plasminogen Activator
Authors: Ribo Marc , Alvarez-Sabín José , Montaner Joan , Romero Francisco , Delgado Pilar , Rubiera Marta , Delgado-Mederos Raquel , Molina Carlos A.
Published: March 2006

Background and Purpose—

Intravenous thrombolysis in stroke achieves arterial recanalization in &50% of cases. Determining temporal profile of recanalization may address patient selection and potential benefits of further rescue reperfusion techniques.

Methods—

We studied 179 consecutive intravenous tissue plasminogen activator (t-PA)–treated patients with intracranial artery occlusion. Continuous transcranial Doppler assessed recanalization (none-partial-complete) at 60 minutes (early), 120 minutes (delayed) after t-PA bolus, and 6 hours (late) from symptom onset. Outcomes were determined: National Institutes of Health Stroke Scale (NIHSS; 48-hour NIHSS) and 3-month modified Rankin Scale (mRS).

Results—

On admission, 68% of patients presented proximal middle cerebral artery occlusion, median NIHSS 17. Early recanalization was complete for 30 patients (17%), partial for 50 (28%), and none for 99 (55%). Delayed recanalization was complete for 56 patients (31%), partial for 39 (22%), and none for 84 (47%). Although early flow improvement was observed in up to 45% of patients, only 19% of patients with persistent occlusion (11% of total) presented delayed recanalization (odds ratio [OR] delayed/early recanalization, 0.16; 95% CI, 0.085 to 0.304;
P
<0.001). Among patients with persistent occlusion at 2 hours, only 13 (7% of total) presented late flow improvement (OR late/early recanalization, 0.09; 95% CI, 0.043 to 0.196;
P
<0.001). The few patients with late recanalization presented comparable median 48-hour NIHSS to those with early/delayed recanalization (3 versus 4.5;
P
=0.9) and much lower than those with persistent occlusion after 6 hours (3 versus 15;
P
=0.005). At 3 months, the rate of mRS ≤2 was not statistically different between patients with early/delayed versus late recanalization (55% versus 86%;
P
=0.12) but was lower if occlusion persisted 6 hours after onset (22%;
P
<0.001).

Conclusion—

The majority of t-PA-induced recanalizations occur during the first hour after treatment. Recanalizations during the following hours are rare but still related to clinical improvement if achieved within 6 hours from onset. Rescue reperfusion techniques should be considered if flow improvement is not observed 60 minutes after t-PA bolus.
Surface Cloud Forcing in the East Pacific Stratus Deck/Cold Tongue/ITCZ Complex*
Authors: Cronin Meghan F. , Bond Nicholas A. , Fairall Christopher W. , Weller Robert A.
Published: March 2006

Data from the Eastern Pacific Investigation of Climate Studies (EPIC) mooring array are used to evaluate the annual cycle of surface cloud forcing in the far eastern Pacific stratus cloud deck/cold tongue/intertropical convergence zone complex. Data include downwelling surface solar and longwave radiation from 10 EPIC-enhanced Tropical Atmosphere Ocean (TAO) moorings from 8°S, 95°W to 12°N, 95°W, and the Woods Hole Improved Meteorology (IMET) mooring in the stratus cloud deck region at 20°S, 85°W. Surface cloud forcing is defined as the observed downwelling radiation at the surface minus the clear-sky value. Solar cloud forcing and longwave cloud forcing are anticorrelated at all latitudes from 12°N to 20°S: clouds tended to reduce the downward solar radiation and to a lesser extent increase the downward longwave radiation at the surface. The relative amount of solar radiation reduction and longwave increase depends upon cloud type and varies with latitude. A statistical relationship between solar and longwave surface cloud forcing is developed for rainy and dry periods and for the full record length in six latitudinal regions: northeast tropical warm pool, ITCZ, frontal zone, cold tongue, southern, and stratus deck regions. The buoy cloud forcing observations and empirical relations are compared with the International Satellite Cloud Climatology Project (ISCCP) radiative flux data (FD) dataset and are used as benchmarks to evaluate surface cloud forcing in the NCEP Reanalysis 2 (NCEP2) and 40-yr ECMWF Re-Analysis (ERA-40). ERA-40 and NCEP2 cloud forcing (both solar and longwave) showed large discrepancies with observations, being too large in the ITCZ and equatorial regions and too weak under the stratus deck at 20°S and north to the equator during the cool season from July to December. In particular the NCEP2 cloud forcing at the equator was nearly identical to the ITCZ region and thus had significantly larger solar cloud forcing and smaller longwave cloud forcing than observed. The net result of the solar and longwave cloud forcing deviations is that there is too little radiative warming in the ITCZ and southward to 8°S during the warm season and too much radiative warming under the stratus deck at 20°S and northward to the equator during the cold season.
Physically Based Global Downscaling: Regional Evaluation
Authors: Ghan Steven J. , Shippert Timothy , Fox Jared
Published: March 2006

The climate simulated by a global atmosphere–land model with a physically based subgrid orography scheme is evaluated in 10 selected regions. Climate variables simulated for each of multiple elevation classes within each grid cell are mapped according to a high-resolution distribution of surface elevation in each region. Comparison of the simulated annual mean climate with gridded observations leads to the following conclusions. At low to moderate elevations the downscaling scheme correctly simulates increasing precipitation, decreasing temperature, and increasing snow with increasing elevation across distances smaller than 100 km. At high elevations the downscaling scheme correctly simulates decreasing precipitation with increasing elevation. The rain shadow of many mountain ranges is poorly resolved, with too little precipitation simulated on the windward side of mountain ranges and too much on the lee side. The simulated sensitivity of surface air temperature to surface elevation is too strong, particularly in valleys influenced by drainage circulations. Observations show little evidence of a “snow shadow,” so the neglect of the subgrid rain shadow does not produce an unrealistic simulation of the snow distribution. Summertime snow area, which is a proxy for land ice, is much larger than observed, mostly because of excessive snowfall but in some places because of a cold bias. Summertime snow water equivalent is far less than the observed thickness of glaciers because a 1-m upper bound on snow water is applied to the simulations and because snow transport by slides is neglected. The 1-m upper bound on snow water equivalent also causes an underestimate of seasonal snow water during late winter, compared with gridded station measurements. Potential solutions to these problems are discussed.
Surface Albedo Feedback Estimates for the AR4 Climate Models
Authors: Winton Michael
Published: March 2006

A technique for estimating surface albedo feedback (SAF) from standard monthly mean climate model diagnostics is applied to the 1% yr−1 carbon dioxide (CO2)-increase transient climate change integrations of 12 Intergovernmental Panel on Climate Change (IPCC) fourth assessment report (AR4) climate models. Over the 80-yr runs, the models produce a mean SAF at the surface of 0.3 W m−2 K−1 with a standard deviation of 0.09 W m−2 K−1. Relative to 2 × CO2 equilibrium run estimates from an earlier group of models, both the mean SAF and the standard deviation are reduced. Three-quarters of the model mean SAF comes from the Northern Hemisphere in roughly equal parts from the land and ocean areas. The remainder is due to Southern Hemisphere ocean areas. The SAF differences between the models are shown to stem mainly from the sensitivity of the surface albedo to surface temperature rather from the impact of a given surface albedo change on the shortwave budget.
Improved Analyses of Changes and Uncertainties in Sea Surface Temperature Measured In Situ since the Mid-Nineteenth Century: The HadSST2 Dataset
Authors: Rayner N. A. , Brohan P. , Parker D. E. , Folland C. K. , Kennedy J. J. , Vanicek M. , Ansell T. J. , Tett S. F. B.
Published: March 2006

A new flexible gridded dataset of sea surface temperature (SST) since 1850 is presented and its uncertainties are quantified. This analysis [the Second Hadley Centre Sea Surface Temperature dataset (HadSST2)] is based on data contained within the recently created International Comprehensive Ocean–Atmosphere Data Set (ICOADS) database and so is superior in geographical coverage to previous datasets and has smaller uncertainties. Issues arising when analyzing a database of observations measured from very different platforms and drawn from many different countries with different measurement practices are introduced. Improved bias corrections are applied to the data to account for changes in measurement conditions through time. A detailed analysis of uncertainties in these corrections is included by exploring assumptions made in their construction and producing multiple versions using a Monte Carlo method. An assessment of total uncertainty in each gridded average is obtained by combining these bias-correction-related uncertainties with those arising from measurement errors and undersampling of intragrid box variability. These are calculated by partitioning the variance in grid box averages between real and spurious variability. From month to month in individual grid boxes, sampling uncertainties tend to be most important (except in certain regions), but on large-scale averages bias-correction uncertainties are more dominant owing to their correlation between grid boxes. Changes in large-scale SST through time are assessed by two methods. The linear warming between 1850 and 2004 was 0.52° ± 0.19°C (95% confidence interval) for the globe, 0.59° ± 0.20°C for the Northern Hemisphere, and 0.46° ± 0.29°C for the Southern Hemisphere. Decadally filtered differences for these regions over this period were 0.67° ± 0.04°C, 0.71° ± 0.06°C, and 0.64° ± 0.07°C.
Modulation of Tropical Intraseasonal Oscillations by Ocean–Atmosphere Coupling
Authors: Rajendran K. , Kitoh A.
Published: March 2006

The impact of ocean–atmosphere coupling on the structure and propagation characteristics of 30–60-day tropical intraseasonal oscillations (TISOs) is investigated by analyzing long-term simulations of the Meteorological Research Institute coupled general circulation model (CGCM) and its stand-alone atmospheric general circulation model (AGCM) version forced with SSTs derived from the CGCM and comparing them with recent observation datasets [Global Precipitation Climatology Project (GPCP) precipitation, 40-yr European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA-40), and Reynolds SST]. Composite events of (i) eastward propagating Madden–Julian oscillations (MJOs) during boreal winter and (ii) northward propagating intraseasonal oscillations (NPISOs) during boreal summer, constructed based on objective criteria, show that the three-dimensional structure, amplitude, and speed of propagation, and the phase relationship among surface fluxes, SST, and convection, are markedly improved in the CGCM simulation.

Consistent with the frictional wave conditional instability of the second kind mechanism, successive development of low-level convergence to the east (north) of deep convection was found to be important for eastward (northward) propagation of MJO (NPISO). Complex interaction between large-scale dynamics and convection reveals the importance of atmospheric dynamics and suggests that they are intrinsic modes in the atmosphere where coupling is not essential for their existence. However, as in observations, realistic coupling in the CGCM is found to result in the evolution of TISOs as coupled modes through a coherent coupled feedback process. This acts as an amplifying mechanism for the existing propagating convective anomalies and plays an important modifying role toward a more realistic simulation of TISOs. In contrast, the simulated TISOs in its atmosphere-alone component lack many of the important features associated with their amplitude, phase, and life cycle. Thus, a realistic representation of the interaction between sea surface and the atmospheric boundary layer is crucial for a better simulation of TISOs.
The Effect of the MJO on the North American Monsoon*
Authors: Lorenz David J. , Hartmann Dennis L.
Published: March 2006

The effect of the Madden–Julian oscillation (MJO) in the eastern Pacific on the North American monsoon is documented using NCEP–NCAR reanalysis and daily mean precipitation data from 1958 to 2003. It is found that positive zonal wind anomalies in the eastern tropical Pacific lead to above-normal precipitation in northwest Mexico and Arizona from several days to over a week later. This connection between the tropical Pacific and monsoon precipitation appears to be limited to regions influenced by moisture surges from the Gulf of California as a similar connection does not exist for New Mexico precipitation. The evidence suggests that the MJO might affect monsoon precipitation by modulating the strength of low-level easterly waves off the coast of Mexico, which in turn triggers the development of a gulf surge.
Exposure to Community Violence and Childhood Delinquency
Authors: Patchin Justin W. , Huebner Beth M. , McCluskey John D. , Varano Sean P. , Bynum Timothy S.
Published: March 2006

Community-level factors such as disadvantage, disorder, and disorganization have been linked to a variety of antisocial and illicit activities. Although crime and deviance tend to concentrate in areas with these characteristics, not all residents of disorganized neighborhoods participate in proscribed activities. This study examines the relationship between exposure to community violence and involvement in assaultive behavior and weapon carrying among a sample of at-risk youth. Findings demonstrate that controlling for the effects of neighborhood disadvantage as well as other common correlates of delinquency (e.g., family supervision and structure, school attachment, and peer delinquency), youth who witnessed more violence in their neighborhoods were more likely to self-report assaultive behavior and weapon carrying. This research has important implications for the study of delinquency by further identifying the social costs of community violence.
Self-Control and Variability Over Time: Multivariate Results Using a 5-Year, Multisite Panel of Youths
Authors: Winfree L. Thomas , Taylor Terrance J. , He Ni , Esbensen Finn-Aage
Published: March 2006

Gottfredson and Hirschi claimed, as part of their general theory of crime, that a child’s criminal propensity, what they called level of self-control, is fairly fixed by age 10. Low self-control children, they further claimed, exhibit greater proclivities for delinquency and analogous behaviors than children with high levels of self-control. They see self-control levels for children at both ends of the spectrum—and their propensities for crime and analogous behaviors—as immutable over the life course. The authors explore the self-control levels, self-reported illegal behavior, and supporting attitudes exhibited by a panel of youths from in six cities at five points in time. Some of our findings substantiated Gottfredson and Hirschi’s claims (e.g., claims linking self-control, sex, and race or ethnicity); however, other findings are at odds with their theory (e.g., the unchanging nature of self-control). The authors review the implications of these findings for self-control theory.
The Organizational Determinants of Police Arrest Decisions
Authors: Chappell Allison T. , MacDonald John M. , Manz Patrick W.
Published: March 2006

A limited amount of research has examined the relationship between characteristics of police organizations and policing styles. In particular, few studies have examined the link between organizational structures and police officer arrest decisions. Wilson’s (1968) pioneering case study of police organizations suggested that individual police behavior is a function of departmental goals that occur within the broader political climate of a community. Wilson suggested that agencies could be classified into three typologies: the watchman style, the legalistic style, and the service style. The present study examines the influence of organizational characteristics associated with these styles on individual officers’ arrest rates using nationally representative data from large police agencies. Findings suggest that police officer arrest decisions are partially explained by variations in police organizational structures. The implications of these findings for contemporary organizational explanations of police behavior are discussed.
An Examination of Citizen Involvement in Crime Prevention in High-Risk Versus Low- to Moderate-Risk Neighborhoods
Authors: Pattavina April , Byrne James M. , Garcia Luis
Published: March 2006

In the following study, the authors examine factors that explain citizen participation in crime prevention activities in Boston. Using survey data from a random sample, census data, and official crime and arrest data, the authors identified a wide range of individual- and community-based indicators that could potentially explain citizen involvement in crime prevention. Findings revealed that citizen involvement in collective crime prevention does indeed vary by the risk level of a particular neighborhood, with high-risk neighborhoods demonstrating higher rates of involvement than low- to moderate-risk neighborhoods. The authors also found that the factors that explained citizen participation varied by the risk level of the neighborhood. Overall, this research demonstrated that in high-risk neighborhoods, citizen involvement in crime prevention activities is affected by the unique blend of personal, parochial, and public social control mechanisms operating in these areas.
The Role of Existential Meaning as a Buffer Against Stress
Authors: Mascaro Nathan , Rosen David H.
Published: March 2006

An ethnically diverse sample of 143 college undergraduates was used to test the hypothesis that a sense of existential meaning buffers against the effect of stress on depression and hope. Spiritual meaning as measured by the Spiritual Meaning Scale and personal meaning as measured by the framework subscale from the Life Regard Index-Revised were significantly negatively correlated with depressive symptoms and positively correlated with hope. Spiritual meaning, but not personal meaning, moderated the relationship between stress and depression such that there was a strong relationship between depression and stress for individuals with low levels of spiritual meaning but no relationship between stress and depression for individuals with high levels of spiritual meaning. It appears that, though both spiritual and personal meaning are inversely related to depression and positively related to hope, only spiritual meaning moderates the relationship between daily stress and depression.
What’s Love Got to Do With It? The Relational Nature of Depressive Experiences
Authors: Granek Leeat
Published: March 2006

Clinical depression is a condition that involves depressed mood and intense sadness that lasts for more than a “normal” span of time. Depression has been considered a medical disorder by psychiatry and as such has been researched through “objective” positivist empirical methods. Very few in-depth qualitative studies on depression have been undertaken. This study looked at the depressive experience from a subjective perspective and found that depression is a complex process that involves relationships. Using methodical hermeneutical approach, (revised version of grounded theory), this study found that depression was largely a relational phenomenon. Under this category, three findings arose: self in relation, self-criticism and self-loathing, and loneliness and disconnection. Further conclusions suggest that the traditional medical “objective” conceptualization of depression is inadequate for understanding the totality of the depressed experience and that more emphasis should be placed on the “subjective” aspect of the condition.
The Paradox of Children in Clergy Families
Authors: Darling Carol Anderson , McWey Lenore M. , Hill E. Wayne
Published: March 2006

The purpose of this research is to understand the effect of the presence of children in the home on the quality of life of clergy and clergy spouses. A survey research design is used involving a random sample of 232 clergy and 169 clergy spouses. Data are collected pertaining to selected variables in the ABC-X model of family stress. Discriminant analysis reveals that the ABC-X model of family stress could be used to predict whether or not clergy and spouses have children in the home. Implications of these findings are discussed.
Assisted Reproduction and the Courts
Authors: Maule Linda S. , Schmid Karen
Published: March 2006

In this article, the authors analyze appellate court cases heard in California between 1960 and 2000 that focus on the status of children conceived through reproductive technology in an effort to examine the role of the courts in defining parentage and family in the late 20th and early 21st centuries. In the absence of legislation, the primary locus of family policy regarding children created via reproductive technology will continue to be the courts.
“I Wish We Had More Time to Spend Together...”
Authors: Roxburgh Susan
Published: March 2006

In this article, I examine the distribution of time pressure associated with the roles of marital partner and parent using data from a telephone survey. Results of an analysis of open-ended responses indicate that less than a quarter of respondents are satisfied with the time they spend with their children and spouses. Women are more likely to want to improve the quality of family time, whereas men are somewhat more likely to want more time with their spouses and children. Regression analysis indicates that social support, hours of paid labor, hours of housework, job control, and having dependent children are all associated with significant variation in family time pressures. In contrast to research on general time pressure, there are no socioeconomic differences in family time pressures, and women do not experience significantly higher family time pressures than men do.
A Multifaceted Approach to the Mental Health Advantage of the Married
Authors: Bierman Alex , Fazio Elena M. , Milkie Melissa A.
Published: March 2006

This study takes a multifaceted approach to examining reasons for the well-noted mental health advantage of the married. The authors examine whether socioeconomic resources and psychosocial resources explain this advantage for three aspects of mental health by comparing the consistently married to different types of unmarried individuals, as well as the remarried. The authors find that even though the consistently married generally fare better than all the other groups, the reasons for this advantage not only varied by category of marital status but also, for any specific group, these reasons are sometimes varied depending on the aspect of mental health being examined. This study demonstrates that not only is it advisable for researchers to use a variety of outcome measures to understand the mental health advantage of the married, they should also consider how different resources may explain this advantage, depending on the outcomes and groups being examined.
Killing Monsters
Authors: Williams Susan K. , Hutto Lauren M.
Published: March 2006

The following case study examines a novel treatment strategy used to address one boy's fears, employed in the context of an 8-week psychoeducational counseling experience. As the focus of this article is a specific intervention strategy that occurred during the counseling process, brief information on the theoretical underpinnings, organization, and constituency of the counseling group is provided, although the authors emphasized a single critical incident during which the strategy was implemented. This article emphasizes (a) the flexibility required in conducting this type of group work and the need to adapt group structure to the needs of themembers; (b) the need to sometimes develop novel, and often spontaneous, treatment strategies; (c) the related convergence ofmultiple disciplines (e.g., psychology, religion, medicine); and (d) empathy when working with childhood fears. Related to these factors, specific recommendations for practice and training are outlined.
Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor
Authors: Gu Ben J. , Wiley James S.
Published: March 2006

Matrix metalloproteinase-9 (MMP-9) activity is required for inflammatory response, leukocyte recruitment, and tumor invasion. There is increasing evidence suggesting that the P2X7 receptor of mononuclear cells, which is activated by extracellular adenosine triphosphate (ATP), is involved in inflammatory responses. In this study, ATP caused a rapid release of MMP-9 and a moderate decrease in tissue inhibitor of metalloproteinase 1 (TIMP-1) release from human peripheral-blood mononuclear cells (PBMCs) over a 30-minute time course. The release was time- and dose-dependent and dissociated from ATP-induced cell death. BzATP, which is the most potent agonist for the P2X7 receptor, also caused a similar effect at a lower dosage. ATP-induced MMP-9 release was inhibited by the P2X7 receptor antagonists periodate oxidized ATP and KN-62, or by calcium chelators, as well as by a loss-of-function polymorphism in the P2X7 receptor, but not by brefeldin A, monensin, or cycloheximide, or by anti–tumor necrosis factor-α (TNF-α) or anti–interleukin-1β (IL-1β) monoclonal antibodies. Results from purified subsets of PBMCs showed monocytes were the major source for MMP-9 and TIMP-1 release, and ATP remained effective in purified monocyte and T-cell populations. These observations suggest a novel role for P2X7 as a pro-inflammatory receptor involved in rapid MMP-9 release and leukocyte recruitment.
PKCθ and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes
Authors: Hermann-Kleiter Natascha , Thuille Nikolaus , Pfeifhofer Christa , Gruber Thomas , Schäfer Michaela , Zitt Christof , Hatzelmann Armin , Schudt Christian , Leitges Michael , Baier Gottfried
Published: March 2006

We here investigate the crosstalk of PKC and PKA signaling during primary CD3+ T-lymphocyte activation using pharmacologic inhibitors and activators in combination with our established panel of PKC isotype–deficient mouse T cells in vitro. PKCθ and PKA inversely affect the CD3/CD28-induced IL-2 expression, whereas other PKC isotypes are dispensable in this signaling pathway. Gene ablation of PKCθ selectively results in a profound reduction of IL-2 production; however, complete abrogation of IL-2 production in these PKCθ–/– T cells was achieved only by simultaneous coactivation of the cAMP/PKA pathway in CD3+ T cells. Conversely, the reduced IL-2 production in PKC inhibitor–treated T cells can be rescued by inhibition of the cAMP/PKA pathway in wild-type but not in PKCθ–/– T cells. Mechanistically, the cAMP/PKA and PKCθ pathways converge at the level of NF-AT, as shown by DNA binding analysis. The combined increase in PKA and decrease in PKCθ activity leads to an enhanced inhibition of nuclear NF-AT translocation. This PKCθ/PKA crosstalk significantly affects neither the NF-κB, the AP-1, nor the CREB pathways. Taken together, this opposite effect between the positive PKCθ and the negative cAMP/PKA signaling pathways appears rate limiting for NF-AT transactivation and IL-2 secretion responses of CD3+ T lymphocytes.