Squamous cell carcinomas of the aryepiglottic fold: Therapeutic results and long‐term follow‐up
Authors: Spector J. Gershon , Sessions D. G. , Haughey B. , Fredrickson J. M. , Emami B. , Simpson J. 
Published: October 2006

Three hundred fifteen patients with squamous cell carcinomas involving the aryepiglottic (A‐E) folds were treated between January 1964 and December 1991. The age ranged from 39 to 87 years (mean, 62.4 years; median, 61.3 years) and the male‐to‐female ratio was 5:1 (54 women and 261 men). Symptom duration prior to diagnosis was 4.8 months. Eighty percent of patients had T3 and T4 lesions and 56.3% had neck metastases at presentation. Six patients (1.8%) had distant metastases and were excluded from this study. Clinically the tumors presented as either exophytic infiltrating lesions which were confined to the A‐E fold (n = 57) or mucosally spreading tumors which extended to the lateral supraglottis or pyriform sinus (n = 258). Prior to 1978 preoperative radiation (3000 to 5000 cGy) was used. Higher doses of postoperative radiation (5000 to 6000+ cGy) were used thereafter. After 1982 the use of myocutaneous flaps for closure of partial laryngopharyngectomy defects was routine. Almost all NO neck disease was treated by radiation or surgery. Combined therapy was used in N1‐N3 disease. One quarter of the patients had single‐modality therapy (25.7%; 81 patients) with a cumulative 5‐year disease‐free survival of 53%. The remainder of the patients (n = 234) had combined therapy with a cumulative 5‐year survival of 67.2%. The latter group had 163 conservation surgeries and 121 total laryngectomy resections. The 5‐year disease‐free survival for preoperative radiation with surgery (68%) and postoperative radiation with surgery (64%) was similar. Those treated by radiation alone had a 34% 5‐year disease‐free survival and those treated with surgery alone had a 61% 5‐year disease‐free survival. The cumulative locoregional control rate was 77%. The cumulative disease‐free survival at 5,10,15, and 20 years is 66%, 57%, 55%, and 55%, respectively.

Infiltrating tumors had a better disease‐free survival (by more than 10%) than spreading tumors. The 5‐year survival rates were separated well by clinical stages of tumors. In patients with T1 tumors the 5‐year survival was 87%; in those with T2 tumors, 80%; in those with T3 tumors, 78%; and in those with T4 tumors, 41%. The survival rate was greater in those with NO tumors than in those with N+ tumors by 25% and greater in those with N1 tumors than in those with N2 + N3 tumors by an additional 18%. The overall complication rate was 26% and in 7.7% these were fatal. The salvage rate after single‐modality therapy was equal for radiation and surgery (66.7%) and after combined therapy was better for surgery 53% (19/36) than radiation 24% (10/41). An incidence of distant metastases (16%), second primary tumors (8%), and death from intercurrent disease (11%) was documented. On a selected basis small T1N0 or T2N0 lesions can be treated equally well with single‐modality therapy (>80%), but larger lesions or neck metastases require combined therapy with higher doses of postoperative radiation. Postoperative radiation reduced the complication rate and treatment‐related fatalities, and increased the locoregional control and overall cure rates.