bluuebunny/crossref_metadata_2025 huggingface dataset:
Degradation Identification of an EHA Piston Pump by Analysis of Load-Holding States
Authors: Duensing Yannick , Merkel Amos , Schmitz Katharina
Published: January 2024

In pursuit of advancing the development of more electric aircraft, the present research explores the forefront capabilities of electro-hydrostatic actuators (EHAs) as potential replacements for conventional hydraulic flight control systems. EHAs are currently used primarily as backup options due to their limited durability. As of now, the high dynamic axial piston pump is the main cause of the limited longevity of the EHA, due to strong tribological wear. The primary objective of this investigation is the identification of parameters and pump behavior to determine the current wear of the pump, as well as providing valuable insights into run-ins, temperature dependencies, and wear-related efficiency losses for future pump improvements. In the scope of this paper, the design of EHAs is explained in detail and the impact of challenging working conditions on the health status of the pump by comprehensive analysis of load-holding modes is examined. The experimental data for analysis is conducted on a longevity test bench with test profiles specifically designed to simulate real-world operational scenarios.
A Binary Medium Constitutive Model for Frozen Solidified Saline Soil in Cold Regions and Its Fractal Characteristics Analysis
Authors: Kang Xinrui , Li Hongbo , Zhang Gang , Li Sheng , Shan Long , Zhao Jing , Zhang Zhe
Published: January 2024

In addressing the issue of strength degradation in saline soil foundations under the salt-freeze coupling effects, a binary medium constitutive model suitable for un-solidified and solidified frozen saline soil is proposed considering both bonding and friction effects. To verify the validity of the constitutive model, freezing triaxial tests are carried out under different negative temperatures, confining pressures, and water contents. The pore structure and fractal characteristics of saline soil are analyzed using mercury intrusion porosimetry (MIP) and the fractal dimension D qualitatively and quantitatively, which shed light on the strength enhancement mechanism during the solidification of frozen saline soils. The results show that the constitutive model for frozen solidified saline soil based on binary medium theory aptly captures the stress–strain relationship before and after the solidification of frozen saline soil. The stress–strain relationship of frozen saline soil before and after solidification can be delineated into linear elasticity, elastoplasticity, and strain-hardening or -softening phases. Each of these phases can be coherently interpreted through the binary medium constitutive model. The un-solidified and solidified frozen both show pronounced fractal characteristics in fractal analysis. Notably, the fractal dimension D of the solidified saline soil exhibits a significant increase compared to that of un-solidified ones. In Regions I and III, the values of D for solidified saline soil are lower than those for untreated saline soil, which is attributed to the filling effect of hydration products and un-hydrated solidifying agent particles. In Region II, the fractal dimensions DMII and DNII of the solidified saline soil exhibit a “non-physical state”, which is mainly caused by the formation of a significant number of inkpot-type pores due to the binding of soil particles by hydration products.
A Systematic Review of Fumagillin Field Trials for the Treatment of Nosema Disease in Honeybee Colonies
Authors: Peirson Michael , Pernal Stephen F.
Published: January 2024

This article systematically reviews controlled field trials of fumagillin dicyclohexylamine in honeybee colonies to determine whether fumagillin effectively controls nosema and whether it is beneficial to colonies. Fifty publications were found that described controlled field trials of fumagillin in honeybee colonies between 1952 and 2023. Fumagillin consistently reduced the prevalence and severity of nosema infections. Doses applied in recent studies were similar to or below those recommended historically. Furthermore, our study showed no negative effects on colony health. Improvements in colony survival, size, and honey production have been demonstrated frequently, though not consistently, in both historic and recent studies. Nevertheless, some practices are not optimal. Treatment decision thresholds based on the number of spores per bee are not well supported by evidence and may be no better than calendar-based prophylactic treatments. In addition, reasonable recommendations to employ quarantine and disinfection procedures together with fumagillin treatment do not appear to have been widely adopted. When used as stand-alone treatments, both the fall- and spring-label doses provide benefits but may be too low and short-term to ensure full control of the disease.
Unlocking the Protective Potential of Upper Respiratory Infection Treatment Histories against Alzheimer’s Disease: A Korean Adult Population Study
Authors: Kang Ho Suk , Kim Ji Hee , Kim Joo-Hee , Bang Woo Jin , Choi Hyo Geun , Kim Nan Young , Park Ha Young , Kwon Mi Jung
Published: January 2024

With increasing interest in the inflammation-pathogen infection hypothesis and its potential links to Alzheimer’s disease (AD) development, there is growing consideration of using upper respiratory infection (URI) treatments as interventions for AD. This nested case–control study explored the potential association between prior URI histories and AD development in a Korean adult population using the national health screening cohort data (2002–2019). The study included 26,920 AD patients and 107,680 matched control individuals, focusing on those seeking respiratory treatment. Logistic regression analyses assessed the impact of URI histories and treatment on AD risk while adjusting for covariates. Our results revealed that over a 1-year period, individuals with URI histories (≥1, ≥2, or ≥3 instances) exhibited decreasing probabilities of developing AD, with risk reductions of 19%, 15%, and 12%, respectively. Expanding our investigation to a 2-year period consistently showed a 17% reduction in AD risk. This effect remained robust across diverse demographic groups and after adjusting for covariates, encompassing comorbidities, hypertension, hyperlipidemia, blood glucose levels, and lifestyle factors. Subgroup analyses further substantiated this association. In conclusion, our findings cautiously suggest a potential protective role of prior URI treatment histories in mitigating the risk of AD development.
Security Vulnerabilities in 5G Non-Stand-Alone Networks: A Systematic Analysis and Attack Taxonomy
Authors: Wani Mohamad Saalim , Rademacher Michael , Horstmann Thorsten , Kretschmer Mathias
Published: January 2024

5G networks, pivotal for our digital mobile societies, are transitioning from 4G to 5G Stand-Alone (SA) networks. However, during this transition, 5G Non-Stand-Alone (NSA) networks are widely used. This paper examines potential security vulnerabilities in 5G NSA networks. Through an extensive literature review, we identify known 4G attacks that can theoretically be applied to 5G NSA. We organize these attacks into a structured taxonomy. Our findings reveal that 5G NSA networks may offer a false sense of security, as most security and privacy improvements are concentrated in 5G SA networks. To underscore this concern, we implement three attacks with severe consequences and successfully validate them on various commercially available smartphones. Notably, one of these attacks, the IMSI Leak, consistently exposes user information with no apparent security mitigation in 5G NSA networks. This highlights the ease of tracking individuals on current 5G networks.
(5Z,9Z)-14-[(3,28-Dioxoolean-12-en-28-yl)oxy]tetradeca-5,9-dienoic Acid with Cytotoxic Activity
Authors: Tuktarova Regina A. , Dzhemileva Lilya U. , Dzhemilev Usein M.
Published: January 2024

For the first time, a synthetic analogue of natural (5Z,9Z)-dienoic acid has been synthesized in the form of a hybrid molecule containing a fragment of oleanolic acid and (5Z,9Z)-tetradeca-5.9-dienedicarboxylic acid, synthesized using a new reaction of Ti-catalyzed homo-cyclomagnesiation 1,2-dienes. The high cytotoxic activity of (5Z,9Z)-14-[(3,28-dioxoolean-12-en-28-yl)oxy]tetradeca-5,9-dienoic acid against tumor cells Jurkat, K562, U937 and HL60 was established. This compound is also an inducer of apoptosis, affects the cell cycle and inhibits human topoisomerase I.
Muscles: An Overview of 2023 and Future Perspective
Authors: Angelini Corrado
Published: January 2024

Ending the year is an opportunity to reflect on the past twelve months [...]
Functionalized Nanomaterials for Inhibiting ATP-Dependent Heat Shock Proteins in Cancer Photothermal/Photodynamic Therapy and Combination Therapy
Authors: Premji Thejas P. , Dash Banendu Sunder , Das Suprava , Chen Jyh-Ping
Published: January 2024

Phototherapies induced by photoactive nanomaterials have inspired and accentuated the importance of nanomedicine in cancer therapy in recent years. During these light-activated cancer therapies, a nanoagent can produce heat and cytotoxic reactive oxygen species by absorption of light energy for photothermal therapy (PTT) and photodynamic therapy (PDT). However, PTT is limited by the self-protective nature of cells, with upregulated production of heat shock proteins (HSP) under mild hyperthermia, which also influences PDT. To reduce HSP production in cancer cells and to enhance PTT/PDT, small HSP inhibitors that can competitively bind at the ATP-binding site of an HSP could be employed. Alternatively, reducing intracellular glucose concentration can also decrease ATP production from the metabolic pathways and downregulate HSP production from glucose deprivation. Other than reversing the thermal resistance of cancer cells for mild-temperature PTT, an HSP inhibitor can also be integrated into functionalized nanomaterials to alleviate tumor hypoxia and enhance the efficacy of PDT. Furthermore, the co-delivery of a small-molecule drug for direct HSP inhibition and a chemotherapeutic drug can integrate enhanced PTT/PDT with chemotherapy (CT). On the other hand, delivering a glucose-deprivation agent like glucose oxidase (GOx) can indirectly inhibit HSP and boost the efficacy of PTT/PDT while combining these therapies with cancer starvation therapy (ST). In this review, we intend to discuss different nanomaterial-based approaches that can inhibit HSP production via ATP regulation and their uses in PTT/PDT and cancer combination therapy such as CT and ST.
Cattle-Urine-Enriched Biochar Enhances Soil Fertility, Nutrient Uptake, and Yield of Maize in a Low-Productive Soil
Authors: Pandit Naba Raj , Sipkhan Pragati , Sharma Shiva Shankar , Dawadi Darmaraj , Vista Shree Prasad , Raut Prashant
Published: January 2024

Poor soil fertility, imbalanced fertilization, and limited use of organic fertilizer by farmers are significant limitations contributing to lower crop productivity in Nepal. Biochar-based organic fertilizers have been identified as efficient soil amendments to improve soil fertility and boost crop yields. In this study, we investigated the effects of biochar-based organic fertilizers on soil properties, fertilizing efficiency, and maize yields in low-productivity Nepalese soil. A field trial was conducted using a randomized complete block design comprising four treatments with three replications: (1) control without biochar (CK), (2) biochar (BC), (3) biochar + manure (BC+M), and (4) urine-enriched biochar + manure (BU+M). Recommended NPK fertilizers were applied to all plots, including the control. Urine-enriched biochar (BU+M) significantly improved soil pH, organic carbon, and soil nutrient levels (N, P, and K) compared to the control (CK). Total N, available P, and K were significantly higher (p < 0.05) in BU+M treatments compared to the other two biochar amendments (BC and BC+M). A similar trend was observed in the NPK uptake by plants, with BU+M outperforming CK, BC, and BC+M. Moreover, BU+M increased (p < 0.05) the partial factor of productivity of N (PFPN) and P (PFPP) compared to CK. The application of urine-enriched biochar resulted in a 62% increase in maize yield compared to the CK. These findings suggest that farmers can improve soil fertility and increase grain production with the use of urine-enriched biochar, which can be easily produced by farmers themselves using locally available feedstocks and cattle urine.
Amebicides against Acanthamoeba castellanii: The Impact of Organism Models Used in Amebicide Assays
Authors: Geres Leonardo Fernandes , Sartori Elena , Neves João Marcos dos Santos , Miguel Danilo Ciccone , Giorgio Selma
Published: January 2024

Acanthamoeba castellanii is a free-living amoeba capable of causing keratitis in humans, with most cases related to contact lens wearers and surgical procedures. In addition, A. castellanii may cause pneumonia, granulomatous encephalitis, and skin lesions in immunocompromised individuals. Considering the lack of adequate treatment for acanthamoebiasis, the aim of this review is to assess relevant original articles that covered the current arsenal of drugs and models of organisms used in the field of experimental A. castellanii infection that have been published within the last 5 years (2018–2023) in journals indexed by the following databases: Electronic Library Online (SciELO), PubMed, Medical Literature Analysis and Retrieval System Online (Medline), Latin American and Caribbean Literature in Health Sciences (Lilacs), Google Academic, and Capes Periodical Portal. Thirty articles were selected, and the main findings showed that the available therapeutics for acanthamoebiasis are still limited and nonspecific, and no innovations have occurred in the last few years. In terms of novel chemotherapeutic advances, the last findings have focused on the activity of natural products (plant-based extracts), nanoemulsions, coated particles, and photodynamic association against A. castellanii, without advancing from the bench to bedside perspective. The choice of a non-representative model system for acanthamoebiasis, as well as the limitations of studies in vivo, impairs the advancement of toxicity analyses. Efforts should be made to expand the model systems used, standardize tests for evaluating anti-A. castellanii drug candidates, and increase and support research groups focusing on the biology of A. castellanii and the pharmacology of acanthamoebiasis.
Chemical Composition and In Vitro Nutritive Evaluation of Pomegranate and Artichoke Fractions as Ruminant Feed
Authors: de Evan Trinidad , Marcos Carlos N. , Carro María Dolores
Published: January 2024

The aim of this work was to assess the chemical composition and in vitro ruminal fermentation of samples (n = 3) of pomegranate (peels (PPs) and seeds (PSs)) and artichoke (hearts (AHs) and stems (ASs)) wastes. Dried orange pulp (DOP) and tomato pomace (TP) were used as reference feeds. All wastes had low dry matter (DM; lower than 33.0 and 12.0% for pomegranate and artichoke, respectively). The DM of pomegranate fractions was rich in sugars (>42.0%) and contained low protein (<8.0%) and neutral detergent fiber (NDF; <27.0%), whereas that of both artichoke fractions had high protein (>18.0%) and NDF (>36.0%) and low sugars content (<9.2%). Pomegranate seeds were more rapidly and extensively fermented in vitro than PPs, but both were less degradable and contained less metabolizable energy (ME) than DOP (7.43, 11.0 and 12.5 MJ ME/kg DM, respectively). Although AHs were more rapidly fermented and produced more volatile fatty acids (VFAs) than ASs, both had lower ME content than TP (9.50, 7.25 and 12.5 MJ ME/kg DM). The analyzed wastes had lower ME content than other by-products, but they were extensively fermented by ruminal microorganisms and could be used as ruminant feeds.
Geometric Analysis of Seed Shape Diversity in the Cucurbitaceae
Authors: Martín-Gómez José Javier , Gutiérrez del Pozo Diego , Rodríguez-Lorenzo José Luis , Tocino Ángel , Cervantes Emilio
Published: January 2024

The Cucurbitaceae is a monophyletic family with close to 1000 species of climbers, including important agronomic species and varieties characterized by tendrils and pepo fruits. The seed’s morphology is varied, and the development and structure of the seed coat have been described in detail on some species. Overall description of the seed shape is based on terms comparing it with geometric figures, but quantitative methods are lacking in the literature. Here we apply a general morphological analysis to seeds of representative genera of the Cucurbitaceae, followed by curvature analysis in the poles and symmetry analysis. These methods are useful for the quantitative description of seed shape and the comparison between species and varieties. Differences between species were found for most morphological measurements, as well as for symmetry and curvature values. The comparison between three species of Cucumis (Cucumis sativus, C. myriocarpus and C. melo) and two varieties of C. melo reveals differences between species and varieties both in curvature and symmetry. The results obtained from both methods, curvature and symmetry analysis, form similar groupings in a cluster analysis. The methods described here were applied for the identification of agronomic varieties and the quantitative description of seed shape in taxonomy.
A Novel Virtual Arrival Optimization Method for Traffic Organization Scenarios
Authors: Shao Tianhao , Du Weijie , Ye Yun , Li Haoqing , Dong Jingxin , Liu Guiyun , Zheng Pengjun
Published: January 2024

The International Maritime Organization (IMO) has been progressively implementing stricter regulations on ship carbon emissions, leading to many vessels adopting the virtual arrival (VA) method to reduce their carbon footprint. However, the effectiveness of the traditional VA method often varies in busy ports with complex traffic organization scenarios. To address this, our study presents a novel, comprehensive model that integrates vessel scheduling with the VA approach. This model is designed to achieve a dual objective: reducing carbon emissions through virtual arrival while simultaneously minimizing vessel waiting times. In addition to these goals, it incorporates essential aspects of safety, efficiency, and fairness in port management, utilizing the NSGA-2 algorithm to find optimal solutions. This model has been tested and validated through a case study at Ningbo-Zhoushan port, employing its dataset. The results demonstrate that our innovative model and algorithm significantly outperform traditional scheduling methods, such as First-Come-First-Serve (FCFS) and Virtual-Arrival Last-Serve (VALS), particularly in terms of operational efficiency and reduction in vessel carbon emissions.
Foreign Ownership and State-Owned Enterprises’ Innovation: The Mediating Role of Host Country’s Innovation Level and the Moderating Effect of Government Innovation Subsidies
Authors: Wu Chong , Yue Mengyao , Huang Fang , Wu Songqiao
Published: January 2024

From the perspectives of ownership dispersion degree after the entry of foreign shareholder and the foreign ownership participation level, respectively, this paper takes Chinese hybrid OFDI state-owned listed industrial companies from 2007 to 2019 as samples, using 3799 observations, to study the impact of foreign ownership on the innovation of OFDI SOEs. We find that compared to the ownership dispersion degree after the entry of foreign shareholder, the foreign ownership participation level plays a more active role in the innovation of OFDI SOE. This positive effect is stronger for non-state-holding enterprises and high-pollution industries. Further analysis reveals that the relationship between foreign ownership and the innovation of SOE is mediated and moderated by the host country’s innovation level and government innovation subsidies, respectively. In addition, in comparison with the ownership dispersion degree after the entry of foreign shareholders, the mediating effect of the host country’s innovation level and the moderating effects of government innovation subsidies are significantly enhanced by the foreign ownership participation level. These findings can promote the study of the relationship between mixed-ownership reform and the innovation of Chinese OFDI SOEs. By verifying the impact of foreign ownership on the effectiveness of OFDI SOE innovation, this paper provides a new perspective on the study of mixed-ownership reform. This paper aims to expand the research field on the relationship between mixed-ownership reform and OFDI SOE innovation, providing theoretical implications and facilitating the policy design of promoting SOE reverse technology spillovers through their governance structural reform.
Description of Bisbalus, a New Genus for the Gray Brocket, Mazama cita Osgood, 1912 (Mammalia, Cervidae), as a Step to Solve the Neotropical Deer Puzzle
Authors: Sandoval Eluzai Dinai Pinto , Jędrzejewski Wlodzimierz , Molinari Jesús , Vozdova Miluse , Cernohorska Halina , Kubickova Svatava , Bernegossi Agda Maria , Caparroz Renato , Duarte José Mauricio Barbanti
Published: January 2024

The Neotropical deer genus Mazama is characterized by homoplastic morphological characters, a high karyotypic diversity, and a polyphyletic condition. The species of the genus have been recovered into two multigeneric lineages, the subtribes Odocoileina and Blastocerina, of the tribe Odocoileini (New World deer) in the family Cervidae. Within the Blastocerina, gray brockets include two non-sister species, Subulo gouazoubira, occurring south of the Amazon region, and Passalites nemorivagus, occurring in the Guianas and in the Amazon region. We clarify the taxonomic status and phylogenetic position of Mazama americana citus Osgood, 1912 (referred to as either S. gouazoubira or P. nemorivagus by other authors). We collected a topotype of M. a. citus from the eastern shore of Lake Maracaibo, Venezuela, characterize it morphologically and cytogenetically (conventional banding and fluorescence in situ hybridization), and carry out a phylogenetic analysis of its whole mitogenome and Cytb alongside two additional specimens of M. a. citus from northwestern Venezuela. Our analyses reveal the topotype to be a large gray brocket with a cinnamon band above the eyes and 2n = 61 and FN = 70 karyotype. Using cattle whole chromosome painting and bacterial artificial chromosome X probes, we determined its karyotype to differ in at least 10 rearrangements from that of S. gouazoubira. Bayesian inference recovers M. a. citus within the Blastocerina subtribe, separated phylogenetically from other gray brockets (100% branch value), revealing the Osgood’s gray brocket to be a valid species that should be assigned to a new genus. We propose the generic name Bisbalus, with Bisbalus citus (Osgood, 1912) as the type species.
Quantifying Drivers of Methane Hydrobiogeochemistry in a Tidal River Floodplain System
Authors: Hou Z. Jason , Ward Nicholas D. , Myers-Pigg Allison N. , Lin Xinming , Waichler Scott R. , Wiese Moore Cora , Norwood Matthew J. , Regier Peter , Yabusaki Steven B.
Published: January 2024

The influence of coastal ecosystems on global greenhouse gas (GHG) budgets and their response to increasing inundation and salinization remains poorly constrained. In this study, we have integrated an uncertainty quantification (UQ) and ensemble machine learning (ML) framework to identify and rank the most influential processes, properties, and conditions controlling methane behavior in a freshwater floodplain responding to recently restored seawater inundation. Our unique multivariate, multiyear, and multi-site dataset comprises tidal creek and floodplain porewater observations encompassing water level, salinity, pH, temperature, dissolved oxygen (DO), dissolved organic carbon (DOC), total dissolved nitrogen (TDN), partial pressure of carbon dioxide (pCO2), nitrous oxide (pN2O), methane (pCH4), and the stable isotopic composition of methane (δ13CH4). Additionally, we incorporated topographical data, soil porosity, hydraulic conductivity, and water retention parameters for UQ analysis using a previously developed 3D variably saturated flow and transport floodplain model for a physical mechanistic understanding of factors influencing groundwater levels and salinity and, therefore, CH4. Principal component analysis revealed that groundwater level and salinity are the most significant predictors of overall biogeochemical variability. The ensemble ML models and UQ analyses identified DO, water level, salinity, and temperature as the most influential factors for porewater methane levels and indicated that approximately 80% of the total variability in hourly water levels and around 60% of the total variability in hourly salinity can be explained by permeability, creek water level, and two van Genuchten water retention function parameters: the air-entry suction parameter α and the pore size distribution parameter m. These findings provide insights on the physicochemical factors in methane behavior in coastal ecosystems and their representation in local- to global-scale Earth system models.
Modeling the Structure and Diffusion of Porous Layers
Authors: Satayev Marat , Azimov Abdugani , Iztleuov Gani , Satayeva Lazzat
Published: January 2024

The aim of this work is to develop an adsorber with a fixed bed of adsorbent and a mathematical model of the adsorption bed. On the basis of the theory of fractal clusters, an equation for calculating the layer porosity that takes into account the average cluster radius, the fractal dimension of the cluster structure and the anisotropy index of the adsorbent layer is proposed. The adsorption mechanism in the layer was established, and the proportionality coefficients were estimated based on the tetrahedral packing of grains in the layer. Based on the analysis of the movement of the carrier through the adsorption layer and its deformation, an equation that describes the change in the porosity of the granular layer when the water flow moves through it, depending on the proportionality coefficients, is proposed. An equation that made it possible to calculate the change in the porosity of the layer in comparison with the porosity of the stationary stacking was obtained. An effective design for the adsorber that made it possible to increase the efficiency of using the structure of porous adsorption layers was developed. Equations of the heat and mass transfer taking into account the granule shape coefficient, effective diffusion coefficient and mass transfer coefficient were derived. These equations establish the relationship between the average distance between active centers on the adsorption surface and the degree of filling of the adsorption surface with the adsorbed component.
Numerical Investigation of Heat Production in the Two-Wheeler Electric Vehicle Battery via Torque Load Variation Test
Authors: Pujowidodo Hariyotejo , Prasetyo Bambang Teguh , Soewono Respatya Teguh , Sutriyanto Himawan , Maswan Achmad , Helios Muhammad Penta , Sumarah Kanon Prabandaru , Nuryadin Bhakti , Fathoni Andhy Muhammad , Arthanto Dwi Handoko , Komara Riki Jaka , Nuryadi Agus Prasetyo , Fitrianto  , Chairunnisa  , Uttariyani I.G.A.
Published: January 2024

Experimental studies were conducted to investigate the effect of varying torque loads on the temperature distribution on the surface of lithium-ion batteries (72 volts–20 Ah) in real commercial two-wheeler electric vehicles as part of our previous research. An electric vehicle engine was installed in a dyno testing laboratory and used as the main load for the battery. Ambient temperature and relative humidity were controlled using an air conditioning system. The test results are presented as surface temperature distributions on each side of the battery at various torque loads. The highest temperature on the battery’s surface was found to be approximately 40 °C at a torque load of 100%. Unfortunately, the heat generated by the battery during testing could not be measured for further research. This paper presents a numerical study of battery heat generation at 100% torque load using Ansys Fluent 2020 R1©. This tool is employed to calculate the heat flux from the battery surface to the ambient air. The CFD tool was initially validated against available experimental data and commonly used correlations for natural convection along a vertically heated wall. Good agreements between the current predictions and experimental data were observed for laminar flow regimes. Convective heat transfer between the battery surface and ambient air was simulated. The results indicate that the commonly used heat transfer correlation for vertical plates accurately predicts the heat transfer rate on the battery surface, and it was found that the heat generation rate is 1199 W/m3.
Gamificación de las leyendas de la ciudad de Riobamba utilizando la plataforma DREAMS
Authors: Olmedo Vargas Israel Alexander , Narváez Vilema Miryan Estela , Espíndola Garcés Adrián Humberto
Published: January 2024

Los videojuegos han emergido como una poderosa herramienta educativa versátil que puede tener un impacto significativo en el aprendizaje de los estudiantes. Cuando se integran de manera adecuada y equilibrada en el entorno educativo, los videojuegos tienen el potencial de hacer que el proceso de aprendizaje sea más atractivo, interactivo y efectivo para los estudiantes de todas las edades. La finalidad de este trabajo investigativo fue desarrollar un videojuego infantil de las leyendas de la ciudad de Riobamba, utilizando la plataforma DREAMS como un método de gamificación para el proceso de enseñanza aprendizaje de los estudiantes de quinto de básica de la escuela San Mateo. El videojuego cumple con funciones, características y conceptos claros y concretos, con una gran capacidad de ser entendida por el público objetivo, gracias a la implementación de la metodología de desarrollo SUM, que proporciona diferentes fases que otorgan al desarrollador definir y estructurar actividades, gestionando los posibles riesgos que puedan surgir a través de ellas, esta cuenta con cinco fases principales: planificación, elaboración, beta, cierre y gestión de riesgos. Por último, para saber si el videojuego cumple con los estándares establecidos y determinar si efectivamente puede ser utilizado como un método de enseñanza se evalúa. La validez del marco de trabajo fue comprobada con la aplicación de distintos parámetros sugeridos por la escala de Likert, obteniendo una alta satisfacción y criterios positivos a partir de su utilización.
The Influence of Perceived Risk and Travel Constraints to Travel Intention of Women Traveler in Bandung City
Authors: Ramadhani Iqlima
Published: January 2024

This study aims to investigate the influence of perceived risk and travel constraints to travel intention of women travelers in Bandung city. A quantitative study was conducted in this research and data were collected from 350 women travelers in Bandung City using purpose sampling. The theories used in this research about perceived risk, theories about travel constraints, and theories about travel intentions. The results of this study revealed that the perceived risk and travel constraints significantly affected the travel intention of women travelers in Bandung by 81.5% while the remaining 18.5% was influenced by other variables not observed in this study. In this case, special attention is needed related to the existing security conditions in the city of Bandung relating to criminal acts that occur. In addition,  optimizing women travelers as one of the largest segmentation in the tourism industry, in this case tourism service businesses, especially travel agents can take advantages of this momentum by creating  and providing a special tour package for women travelers.
Meningioma transicional intracraniano em felino: relato de caso
Authors: Da Silva Lídia Novais , Franco Guilherme Galhardo , Montebeller Ana Carolini , Da Ross Lucas Chastalo , Menenguci Gabriele Alves , Carvalho Elizabeth Regina , Faria Nátali Barbosa , De Oliveira Leticia Leal
Published: January 2024

Os tumores intracranianos primários, tais como os meningiomas, são os mais diagnosticados em felinos. Essas condições podem ser identificadas por meio de técnicas de imagem, como tomografia computadorizada (TC) e ressonância magnética (RM), que desempenham um papel crucial no diagnóstico. O tratamento preferencial para esses casos envolve intervenções cirúrgicas, como craniotomias. Neste estudo, um felino foi admitido no hospital veterinário da Universidade Federal do Espírito Santo com histórico de convulsões. Durante o exame neurológico, não foram observadas anormalidades além das crises focais, nas quais o animal apresentava nistagmo horizontal, perda súbita de equilíbrio e ataxia vestibular. Com o auxílio da TC, foi possível estabelecer um diagnóstico presuntivo de meningioma. O felino foi submetido a uma craniotomia rostrotentorial direita para a remoção do tumor localizado no lobo temporal direito. Durante o procedimento, houve a necessidade de substituição da dura-máter, utilizando um fragmento de fáscia lata do músculo temporal, além da substituição da calota craniana com polimetilmetacrilato. Logo após a cirurgia, o animal demonstrou estado de alerta e foi liberado para internação, recebendo alta no dia seguinte. A calota craniana e o tumor foram encaminhados para análise histopatológica, a qual forneceu o diagnóstico definitivo de meningioma transicional. O objetivo deste estudo foi relatar um caso de meningioma transicional intracraniano em um felino.
Utilizando uma atividade gamificada para abordar os conceitos/ativos de renda fixa e renda variável no ensino de matemática
Authors: Correia Ricardo Felipe Ramos , De Sales Mayco Douglas Lima , Ribeiro Ketlen Alves
Published: January 2024

Este trabalho tem como objetivo discorrer sobre a aprendizagem dos alunos nas atividades gamificadas acerca de investimentos financeiros. Destacamos como fundamentos teóricos da pesquisa, orientações sobre a Educação Financeira escolar, os tipos de investimentos financeiros e as perspectivas metodológicas de sala de aula invertida, gamificação, o uso de tecnologias digitais e seminários. A pesquisa foi executada em uma escola estadual, em uma disciplina eletiva denominada “Investir ou perder, a maratona da vida”. O público alvo foram os alunos do 2º e 3º anos do Ensino Médio. A sequência de atividades foi desenvolvida em duas etapas: Na primeira etapa, realizamos uma sala de aula invertida com quatro apresentações acerca dos tipos de investimentos. Na segunda etapa, aprofundamos os temas sobre investimentos financeiros, a partir de sala de aula Invertida e Kahoot. Acerca do quis, das 25 questões cinco foram consideradas difíceis pelos alunos, teve muito interesse dos alunos, pois a cada pergunta do Kahoot, a ordem dos pontos é atualizada e o clima da competição é criado, fazendo que essa atividade gamificada fizesse com que os alunos aprendessem se divertindo.
Imunoterapia como alternativa terapêutica para rinite alérgica em paciente pediátrico
Authors: Blanc Gabriela Cortines , Rinaldi Maria Eduarda Beltrão da Rosa , Venetillo Isabella Pagnotta de Santana , Messeder Carina Blanco , Guimarães Pedro Espírito Santo , Milone Carolina Ramos , Gonçalves Lucca Garcia , Branco Julia Ariana Valim , Amorim Maria Helena Miranda , Millon Caroline
Published: January 2024

O presente artigo teve como objetivo discutir, a partir de uma revisão narrativa da literatura, as principais características do desenvolvimento na rinite alérgica na população pediátrica, destacando a imunoterapia como uma das formas de tratamento farmacológico mais atuais. A rinite é uma doença decorrente da inflamação e ou disfunção da mucosa de revestimento nasal e das estruturas subjacentes, mediada por imunoglobulinas após a exposição a um alérgeno. Trata-se de uma doença mais prevalente na infância e é caracterizada por sintomas como obstrução nasal, rinorreia anterior e posterior, espirros, prurido nasal e hiposmia. O tratamento da rinite alérgica é baseado no controle da exposição aos alérgenos e, quando não é suficiente, é adicionado o tratamento farmacológico. Atualmente, a imunoterapia tem sido amplamente e estudada e utilizada de maneira segura e eficaz, com o objetivo reduzir os sintomas numa próxima exposição e induzir tolerância a longo prazo. As principais formas de administração de imunoterapia analisadas foram a sublingual, subcutânea e nasal. Os estudos comprovaram a eficácia da via subcutânea e sublingual, aceitas como boa forma de tratamento. Ao comparar a segurança entre ambas as vias, a sublingual apresentou efeitos adversos mais brandos e de fácil resolução.
The impact of positive vas deferens in the biochemical relapse in patients with stage T3b prostate cancer submitted to radical Prostatectomy
Authors: Ottainano Arthur Degani , Ferruccio Aline Akel , Matheus Marina Bertolini , Naccarato Angela Maria Elizabeth Piccolotto , Billis Athanase , Ferreira Ubirajara , Matheus Wagner Eduardo
Published: January 2024

The study aimed to evaluate the influence of invasion of the vas deferens and seminal vesicles in patients undergoing radical prostatectomy for stage T3b tumor on biochemical recurrence.Methods: Retrospective analysis of 53 patients submitted to radical prostatectomy with anatomopathological stage T3b, at Hospital de Clínicas da Unicamp, between 1997 and 2014. After exclusion criteria were applied, statistical analysis of 32 participants separated into 2 groups, in which 20 patients (62.5 %) without involvement of the vas deferens (group 1) and 12 (37.5%) with invasion of the vas deferens (group 2). Biochemical recurrence was defined as an increase in prostate specific antigen (PSA) greater than or equal to 0.2 ng/ml after surgery. Results: Regarding the disease-free survival analysis, group 2 has a 3.05 times greater risk of having a biochemical recurrence compared to group 1 (HR 3.05, 95% CI 1.12-8.32, p=0.03), calculated by regression of Cox and Log Rank test. Conclusion: In conclusion, this study has identified an elevated risk of biochemical recurrence in patients with both ductus deferens and seminal vesicle invasion.
Tratamento homeopático pelo SUS
Authors: Dos Santos Gabriel do Ó , Holanda Fernanda Cavalcante
Published: January 2024

O tratamento Homeopático é uma prática integrativa milenar, que surge a partir do início do século IV a.C onde Hipócrates “Pai da medicina” determina o princípio da lei dos semelhantes, buscando de modo claro e objetivo que para cuidar de uma enfermidade é necessário que um fármaco exerça o mesmo potencial que testado em um paciente saudável. A partir daí, foram iniciados diversos estudos com base neste princípio, a busca de evidenciar a importância das práticas integrativas. A Homeopatia divide-se em quatro pilares, sendo eles; similitude (a mesma droga que causa seus sintomas pode ser utilizada para cura-los), experimentação patogênica (avaliar os efeitos que os medicamentos podem gerar), diluição de mínimas doses (menor incidência de efeitos colaterais) e princípio do medicamento unificado (tratamento menos invasivo). Com base nisso, o tratamento homeopático proporciona os seguintes benefícios aos seus usuários; Anamnese humanizada, Terapia pouco invasiva, diminuição nos efeitos colaterais, com doses menores e tratamentos mais prolongados, tratamento personalizado de acordo com as necessidades do paciente e privando o organismo da ação de diversos fármacos simultâneos. Contudo, no Brasil, apenas no ano de 2006 a homeopatia foi incluída nas práticas integrativas e complementares ofertadas pelo SUS, deixando de ser apenas uma alternativa aos tratamentos convencionais. O presente artigo busca evidenciar a importância dessa prática, de modo a mostrar o leitor de forma clara e objetiva as vantagens que tal tratamento pode proporcionar a quem optar por utiliza-lo, além disso, busca ainda incentivar e disseminar informações essenciais para a aceitação da prática homeopática no âmbito do Sistema Único de Saúde (SUS) e potencializar a ideia de adesão do tratamento homeopático pela população.
Impactos da COVID-19 na odontologia: revisão integrativa
Authors: Lobo Claudia Valeria Moraes , Saraiva Hélia Fernandes , De Castro Nice Souza , Serra Edney Souza , Carvalho Matheus Ricardo Lemos de Araújo , Da Rocha Keila Andrade , Custódio Joelson de Aguiar
Published: January 2024

As pandemias são doenças contagiosas que se espalham globalmente, e a COVID-19, causada pelo vírus SARS-CoV-2, emergiu em dezembro de 2019 na China. O estudo explora como a pandemia alterou os protocolos de segurança, atendimento ao paciente e fluxo de trabalho em consultórios odontológicos, bem como os efeitos do longo prazo dessas mudanças. A pesquisa enfoca os resultados de estudos publicados entre 2020 e 2023 em bases de dados como a MEDLINE, LILACS e BBO - Odontologia. Foi revisada a literatura científica sobre os efeitos da pandemia de COVID-19 na prática odontológica, considerando os aspectos de biossegurança, atenção aos pacientes e organização dos serviços. Foram selecionados 13 artigos que apresentaram evidências relevantes sobre o tema, abordando as mudanças necessárias para garantir a qualidade e a segurança do atendimento odontológico durante e após a crise sanitária. Conclui-se que a pandemia exigiu adaptações rápidas e eficientes para garantir a continuidade do atendimento odontológico de qualidade e a segurança de pacientes e profissionais. Entre as principais medidas adotadas, destacam-se a triagem rigorosa dos pacientes, o uso de equipamentos de proteção individual, a higienização frequente das superfícies e a redução de procedimentos que geram aerossóis. Ressalta-se o papel da teleodontologia na orientação e acompanhamento dos pacientes, especialmente os mais vulneráveis, e na promoção da educação em saúde bucal. Além disso, a pandemia estimulou o desenvolvimento de novas tecnologias e técnicas minimamente invasivas para prevenir e tratar as doenças bucais.
A história da saúde e a política nacional do idoso no Brasil na pauta econômica e social
Authors: Moreira Deiglis Alves
Published: January 2024

O presente artigo é o resultado da reflexão que foi feita sobre a problemática que envolve a história da saúde e a política nacional do idoso no Brasil na pauta econômica e social, observando-se o conceito de saúde, diagnósticos, tratamentos e o papel do estado no controle e na adoção da construção de políticas públicas visando à garantia de cuidados da pessoa idosa pobre. Com o propósito de analisar e estimular a reflexão acerca do que vem sendo discutido por pesquisadores sobre a referida temática, por meio dos documentos oficiais, tais como o Estatuto do Idoso, Pacto de Madrid e a Política Nacional de Atenção a Pessoa Idosa. Neste sentido, foi feito um estudo de revisão, procurando compreender o significado e importância da Política Nacional de Atenção a Pessoa Idosa e as consequências da renda escassa a pessoa idosa pobre no Brasil, reforçando o papel do estado nas estratégias de cuidados de saúde aos idosos mais fragilizados e que podem ter sua expectativa de vida diminuta pela carência econômica. O texto é finalizado com a crítica ao capitalismo, e ao avanço do neoliberalismo que transforma a pessoa idosa pobre em produto de descarte, quando não tem renda ou saberes.
Fatores de risco associados ao desenvolvimento de Câncer de Ovário: revisão integrativa
Authors: Machado Gabrielly Monteiro , Dos Santos Tatiane Batista , Dantas Bárbara Leal , Guimarães Vitória Dantas Monteiro , Santos Anna Maria Beatriz Correia , Tabalipa Gustavo André , Ferreira Thállita Gabriela Freitas , Gois Yasmim Dória Cardoso , Batista Jefferson Felipe Calazans
Published: January 2024

Introdução: O câncer de ovário (CO) é o nono tipo de câncer mais incidente entre as mulheres no mundo e a segunda neoplasia ginecológica mais comum no Brasil. Objetivo: Descrever por meio da revisão de literatura, os fatores de risco associados ao desenvolvimento de câncer de ovário em mulheres. Metodologia: Trata-se de uma revisão integrativa. A busca bibliográfica ocorreu nas bases: Biblioteca Virtual de Saúde (BVS), Scientific Electronic Library Online (SciELO) e Public Medline (PubMed). Descritores foram utilizados para as buscas, usando os operadores AND e OR. Os critérios de inclusão foram: publicações de qualquer período, disponíveis na íntegra e gratuitamente, nos idiomas português, inglês ou espanhol. Resultados: Evidenciou-se diversos fatores de riscos associados ao CO. O tabagismo e o consumo excessivo de café foram identificados como fatores de risco significativos. Por outro lado, o consumo moderado de vinho, especialmente o tinto pode ter um efeito protetor contra o câncer. A predisposição genética, como a presença de mutações BRCA1 e BRCA2, história clínica familiar, menopausa e idade avançada, além do sedentarismo, especialmente em ambientes de trabalho, e a obesidade foram preditores do desfecho estudado. Considerações finais: Faz-se importante o direcionamento de estratégias de prevenção, como campanhas educativas sobre os riscos do sedentarismo, importância de uma dieta equilibrada, realização de exames periódicos, entre outros.
Complicações e acidentes em cirurgias de terceiros molares: uma revisão de literatura
Authors: Da Silva Jaciele Barbosa , Barros Gabriela Cecília Bezerra Rego , Barbosa Analine Pereira , Nascimento Maria Misleynne da Silva , De Mendonça Rayza Dayane Silva , Do Nascimento Talita Álvares , De Santana Dayanne Larissa Ferreira , Ramos Adriano Costa
Published: January 2024

Introdução: Os elementos dentais inclusos ou impactados são àqueles que não erupcionaram da forma esperada dentro da cavidade bucal. Dessa forma, não iniciaram a migração dentária extra óssea para exposição da coroa que deveria irromper o rebordo gengival no osso maxilar ou mandibular. A exodontia dos terceiros molares indubitavelmente, caracteriza-se por cirurgia na qual apresenta seu grau de dificuldade, porém, através do conhecimento e preparação correta do profissional é possível evitar alguns acidentes e complicações advinda no decorrer e pós procedimento cirúrgico. Objetivo: Desta forma, o estudo tem como objetivo ressaltar as devidas complicações e acidentes ocorridos no pós e tráns-cirúrgico na extração dos terceiros molares. Materiais e métodos: O estudo intitulado, trata-se de uma revisão de literatura, baseada através de buscas de dados nas plataformas digitais; Pubmed e SciELO, entre os anos de 2013 à 2023. Utilizando-se os descritores em português: Complicações Pós-Operatórias, Odontologia, Terceiro Molar e Dente não Erupcionado. Resultados: Dessa maneira, conclui-se os principais acidentes e complicações durante a remoção dos terceiros molares, assim como, a importância de um correto planejamento cirúrgico, melhor abordagem para o caso, redução do estresse e, consequentemente, melhor relação para o paciente e teoricamente para o profissional, além de diminuição o tempo operatório e redução dos riscos. Conclusão: Entretanto, o estudo ressalta a forma de tratamento de cada complicação apresentada, assim como, a importância de um planejamento cirúrgico e cautela que o profissional deve ter de acordo com os manejos clínicos e conhecimentos didáticos (cirúrgico e farmacológico) necessários para lidar com a situação, e assim, contribuir para o bem-estar do paciente.