bluuebunny/crossref_metadata_2025 huggingface dataset:
Resistance Exercise Sessions Comprising Multijoint vs. Single-Joint Exercises Result in Similar Metabolic and Hormonal Responses, But Distinct Levels of Muscle Damage in Trained Men
Authors: Barbosa Paulo Henrique , Bueno de Camargo Julio Benvenutti , Jonas de Oliveira José , Reis Barbosa Carolina Gabriela , Santos da Silva Alexsandro , Dos-Santos Julio Wilson , Verlengia Rozângela , Barreira Júlia , Braz Tiago Volpi , Lopes Charles Ricardo
Published: April 2024

Barbosa, PH, Bueno de Camargo, JB, Jonas de Oliveira, J, Reis Barbosa, CG, Santos da Silva, A, Dos-Santos, JW, Verlengia, R, Barreira, J, Braz, TV, and Lopes, CR. Resistance exercise sessions comprising multijoint vs. single-joint exercises result in similar metabolic and hormonal responses, but distinct levels of muscle damage in trained men. J Strength Cond Res 38(5): 842–847, 2024—Resistance-type exercise (RE) elicits distinct acute metabolic and hormonal responses, which can be modulated by the manipulation of training variables. The purpose of this study was to compare the metabolic (blood lactate and estimated lactic anaerobic system energy expenditure) and hormonal (growth hormone [GH]) responses to RE sessions composed exclusively of multijoint (MULTI) or single-joint (SINGLE) exercises. Assessments of creatine kinase (CK) levels were also performed. In a crossover design, 10 recreationally resistance-trained men (age: 26.9 ± 3.0 years, total body mass: 83.2 ± 13.8 kg; height: 176 ± 7.0 cm; training experience: 5.5 ± 2.4 years) were randomly submitted to both protocols. Blood collections were made pre, 3 minutes after, and 36 hours after each experimental session. No significant difference between MULTI vs. SINGLE was observed for the rises in blood lactate (p = 0.057) and GH (p = 0.285) levels. For CK, a significant difference between the protocols was noted, in which MULTI resulted in significant rises after 3 minutes (p = 0.017) and 36 hours (p = 0.043) compared with SINGLE. In conclusion, the findings of this study suggest that resistance-trained individuals display similar metabolic and hormonal responses when performing MULTI and SINGLE exercise protocols. Also, RE sessions comprising MULTI exercises induce a higher magnitude of muscle damage, which may require a longer recovery period compared with SINGLE.
The Force-Vector Theory Supports Use of the Laterally Resisted Split Squat to Enhance Change of Direction
Authors: Cooley Chance , Simonson Shawn R. , Maddy Derek A.
Published: April 2024

Cooley, C, Simonson, SR, and Maddy, DA. The force-vector theory supports use of the laterally resisted split squat to enhance change of direction. J Strength Cond Res 38(5): 835–841, 2024—The purpose of this study was to challenge the conventional change of direction (COD) training methods of the modern-day strength and conditioning professional. A new iteration of the modified single-leg squat (MSLS), the laterally resisted split squat (LRSS), is theorized to be the most effective movement for enhancing COD performance. This study lays out a rationale for this hypothesis by biomechanically comparing the LRSS, bilateral back squat (BS), and MSLS with a COD task (90-degree turn). One repetition maximum (1RM) for LRSS, MSLS, and BS was measured for 23 healthy active female subjects. Peak ground reaction forces (GRF) for the dominant leg were recorded when performing COD and the LRSS, MSLS, and BS at 70% 1RM. Peak frontal plane GRF magnitude and angle were calculated for each task and submitted to repeated measures ANOVA. Peak GRF magnitude was significantly larger for COD (2.23 ± 0.62 body weight) than the LRSS, MSLS, and BS (p ≤ 0.001). Peak GRF angle was not significantly different between COD and the LRSS (p = 0.057), whereas the MSLS and BS (p < 0.001) vector angles were significantly greater than COD. In this application of the force-vector theory, the LRSS more closely matches COD than the MSLS or BS. Thus, the LRSS has the greater potential to enhance COD.
The Effects of Anchoring a Fatiguing Forearm Flexion Task to a High vs. Low Rating of Perceived Exertion on Torque and Neuromuscular Responses
Authors: Ortega Dolores G. , Housh Terry J. , Smith Robert W. , Arnett Jocelyn E. , Neltner Tyler J. , Schmidt Richard J. , Johnson Glen O.
Published: April 2024

Ortega, DG, Housh, TJ, Smith, RW, Arnett, JE, Neltner, TJ, Schmidt, RJ, and Johnson, GO. The effects of anchoring a fatiguing forearm flexion task to a high versus low rating of perceived exertion on torque and neuromuscular responses. J Strength Cond Res 38(5): e219–e225, 2024—This study examined the torque and neuromuscular responses following sustained, isometric, forearm flexion tasks anchored to 2 ratings of perceived exertion (RPE). Nine men (mean ± SD: age = 21.0 ± 2.4 years; height = 179.5 ± 5.1 cm; body mass = 79.6 ± 11.4 kg) completed maximal voluntary isometric contractions (MVIC) before and after sustained, isometric, forearm flexion tasks to failure anchored to RPE = 2 and RPE = 8. The amplitude (AMP) and mean power frequency (MPF) of the electromyographic (EMG) signal were recorded from the biceps brachii. Normalized torque was divided by normalized EMG AMP to calculate neuromuscular efficiency (NME). A dependent t-test was used to assess the mean difference for time to task failure (TTF). Repeated-measures analysis of variances was used to compare mean differences for MVIC and normalized neuromuscular parameters. There was no significant difference in TTF between RPE = 2 and RPE = 8 (p = 0.713). The MVIC decreased from pretest to posttest at RPE = 2 (p = 0.009) and RPE = 8 (p = 0.003), and posttest MVIC at RPE = 8 was less than that at RPE = 2 (p < 0.001). In addition, NME decreased from pretest to posttest (p = 0.008). There was no change in normalized EMG AMP or EMG MPF (p > 0.05). The current findings indicated that torque responses were intensity specific, but TTF and neuromuscular responses were not. Furthermore, normalized EMG AMP and EMG MPF remained unchanged but NME decreased, likely due to peripheral fatigue and excitation–contraction coupling failure. Thus, this study provides information regarding the neuromuscular responses and mechanisms of fatigue associated with tasks anchored to RPE, which adds to the foundational understanding of the relationship between resistance exercise and the perception of fatigue.
Differential Activation States of Direct Pathway Striatal Output Neurons during l-DOPA-Induced Dyskinesia Development
Authors: Figge David A. , de Oliveira Amaral Henrique , Crim Jack , Cowell Rita M. , Standaert David G. , Eskow Jaunarajs Karen L.
Published: April 2024

l-DOPA-induced dyskinesia (LID) is a debilitating motor side effect arising from chronic dopamine (DA) replacement therapy withl-DOPA for the treatment of Parkinson’s disease. LID is associated with supersensitivity of striatal dopaminergic signaling and fluctuations in synaptic DA following eachl-DOPA dose, shrinking the therapeutic window. The heterogeneous composition of the striatum, including subpopulations of medium spiny output neurons (MSNs), interneurons, and supporting cells, complicates the identification of cell(s) underlying LID. We used single-nucleus RNA sequencing (snRNA-seq) to establish a comprehensive striatal transcriptional profile during LID development. Male hemiparkinsonian mice were treated with vehicle orl-DOPA for 1, 5, or 10 d, and striatal nuclei were processed for snRNA-seq. Analyses indicated a limited population of DA D1 receptor–expressing MSNs (D1-MSNs) formed three subclusters in response tol-DOPA treatment and expressed cellular markers of activation. These activated D1-MSNs display similar transcriptional changes previously associated with LID; however, their prevalence and transcriptional behavior were differentially influenced byl-DOPA experience. Differentially expressed genes indicated acute upregulation of plasticity-related transcription factors and mitogen-activated protein kinase signaling, while repeatedl-DOPA-induced synaptic remodeling, learning and memory, and transforming growth factor-β (TGF-β) signaling genes. Notably, repeatedl-DOPA sensitizedInhba, an activin subunit of the TGF-β superfamily, in activated D1-MSNs, and its pharmacological inhibition impaired LID development, suggesting that activin signaling may play an essential role in LID. These data suggest distinct subsets of D1-MSNs become differentiallyl-DOPA-responsive due to aberrant induction of molecular mechanisms necessary for neuronal entrainment, similar to processes underlying hippocampal learning and memory.
Discapacidad y derechos: una mirada desde instrumentos que garantizan la accesibilidad educativa e informativa en Paraguay
Authors: Chamorro Cristaldo María Felicia
Published: April 2024

Disability has evolved historically and has been addressed from a variety of approaches, and the social model underpins the Convention on the Rights of Persons with Disabilities. Another international instrument inspired by the Convention’s principles is the Marrakesh Treaty, which facilitates beneficiaries' access to reading and education. This article aims to examine these agreements approved by Paraguay, which are mechanisms for achieving an equitable and inclusive society. Also under consideration is the progress made in complying with the provisions of the Convention and the axes of the National Action Plan for the Rights of Persons with Disabilities. This public policy tool enables the cross-cutting of this issue in state institutions. A qualitative descriptive study methodology was employed through a bibliographic review of documentary research and technical reports within the scope of the current study's topic. While Paraguay has witnessed legislative progress recognizing the rights of this group, challenges persist in ensuring their effective implementation. Hence, it is crucial to have a coordinated effort between institutions and civil society organizations to achieve legislative initiatives and actions for educational and informational accessibility that consider the needs of this vulnerable social sector.
SIBERIAN SCIENTIST-BREEDER OF FRUIT AND BERRY CROPS VALENTINA NESTEROVNA VASILYEVA (on the 100th anniversary of her birth)
Authors: Доронькин В.М. , Горбунов А.Б.
Published: April 2024

Статья приурочена к 100-летию со дня рождения Валентины Нестеровны Васильевой – ученого–селекционера семечковых и ягодных культур в Сибири.

The article is dedicated to the 100th anniversary of the birth of Valentina Nesterovna Vasilyeva, a scientist and breeder of pome and berry crops in Siberia.
GSEM analysis of environmental factors as the risk of increasing infectious diseases in under-fives to stunting incidence in Solok district
Authors: Lestari Sri , Arlinda Sari , Mukhlis Mukhlis , Lindawati Lindawati , Alhamda Syukra
Published: April 2024

Environment is one of the factors in causing stunting in toddlers. An unhealthy environment can increase the risk of infection for toddlers. Infectious diseases caused by poor hygiene and sanitation can interfere with the absorption of nutrients in the digestive process. Some infectious diseases suffered by babies can cause the baby to lose weight. If this condition occurs for a long time and is not accompanied by sufficient intake for the healing process, it can result in stunting (Ministry of Health, Republic of Indonesia, 2018). When children grow up in an environment with poor sanitation, their risk of getting sick is greater and the possibility of recurrence is also high, this is what causes their growth to be stunted. This research is a quantitative study using a cross sectional study design. This study was conducted to determine environmental factors as a risk in increasing infectious diseases in toddlers against the incidence of stunting in Solok Regency. The population in this study were all mothers who had children under five with stunting in Solok Regency with 200 samples using the Simple Random Sampling (SRS) method for each country according to the needs of this study. The prevalence of stunting in Solok Regency is 82%, with many infectious diseases, namely diarrheal diseases of 57.5%. Environmental factors are still lacking with the availability of healthy latrines at 31%, 23.5% good wastewater treatment, and 35.5% good waste management. Based on the results of the GSEM analysis, it was found that infectious diseases were a direct factor in the incidence of stunting, parenting, diet, and environment were indirect factors for the incidence of stunting.
Modeling the impact of supplementary cementitious materials on compressive strength of recycled aggregate concrete forest-random approach
Authors: Abellán-García Joaquín , Khan M. Iqbal , Abbas Yassir M. , Pellicer-Martínez Francisco
Published: April 2024

Recycled concrete aggregates (RCAs) and supplementary cementitious materials (SCMs) may substitute some cement and natural aggregates (NA) in concrete manufacturing. However, their effects on recycled aggregate concrete (RAC) compressive strength are difficult to model. Reactivity, silica, and alumina modulus were examined for cementitious materials' chemical complexity. Random Forest approaches were developed to predict and analyze RAC compressive strength. Even with RCAs and SCMs, the RF model accurately estimated concrete compressive strength. The Variable Importance (VI) research examined how input factors affected RAC compressive strength. VI indicated that silica fume contributes most to RAC compressive strength, followed by cementitious materials' reactivity modulus, cement content, silica modulus, fine natural aggregate content, and coarse natural aggregate dosage. The water dosage, water/binder ratio, and RCA content lower the RAC compressive strength. As a result, to highlight, the amount of SCM was not significant, but its nature was (i.e., hydraulic, silica pozzolanic, or alumina pozzolanic).
Use of steel slag to improve the mechanical properties of subgrades in clayey soils
Authors: Llatas-Contreras Jhamir A. , Ruiz-Pico Ángel A.
Published: April 2024

Large quantities of steel slag are generated annually throughout the world. Some slag from steel manufacturing is reused in the generation of other materials, such as hot mix asphalt aggregate, pipe filling, concrete, among others. The research aims to enrich the mechanical characteristics of soils and minimize road construction costs. The objective of this research is to find a material that increases the mechanical properties of the subgrade in clay soils with different plasticity indices using Electric Arc Furnace Slag (EAF) in percentages: 5%, 15% and 25% of the weight of the soil. From the tests carried out on the soil samples using parameters, it was possible to classify them by the Unified Soil Classification System (USCS) and also by the American Association of Highway Transportation (AASHTO) as low and high clays. plasticity. When testing the samples in their natural state and the samples with EAF, results were obtained that showed an improvement in the physical and mechanical properties of the clay soils with the addition of EAF, increasing the values of the Bearing Capacity Ratio (CBR) and the maximum dry density. of the clay soil as the percentage of HAE in the mixture increased. The optimal HAE addition content corresponds to 25% of the weight of the soil.
Marco de referencia para el modelamiento y simulación de la ciberdefensa marítima - MARCIM: estado del arte y metodología
Authors: Cabuya-Padilla Diego Edison , Castaneda-Marroquin Carlos Alfonso
Published: April 2024

El artículo presenta el estado del arte y metodología del proyecto de investigación doctoral “Marco de referencia para el modelamiento y simulación de la ciberdefensa marítima – MARCIM”. El estado del arte definió los antecedentes del problema de investigación, estado de la actividad científica, tendencias y retos de las temáticas del MARCIM: ciberdefensa, modelamiento y simulación en ciberseguridad y ciberdefensa; y ciberseguridad y ciberdefensa marítima. La metodología se planteó con un enfoque en modelamiento de sistemas complejos, por fases y actores de aplicación. El artículo concluye principalmente que la ciberdefensa marítima a nivel estratégico se comporta como un sistema complejo, con dinámicas, procesos y elementos que no se pueden identificar claramente, que requieren del modelamiento y simulación, con un enfoque metaheurístico, para estudiar el conjunto de acciones e interacciones entre sus entidades.
First confirmed records of Teratohyla midas (Lynch & Duellman, 1973) (Anura, Centrolenidae) from Bolivia
Authors: Rivas Luis R. , Muñoz Arturo , Eversole Cord B. , Powell Randy L. , Moreno-Aulo Federico
Published: April 2024

Different sources of information indicate the possible presence of Teratohyla midas (Lynch & Duellman, 1973) in Bolivia; however, none of them confirm this scenario. Here we confirm the presence of T. midas in the northern Bolivian Amazon (Pando Department) and extend the geographical distribution of the species to include Bolivia. Likewise, we contribute information on some aspects of this species’ behavior and natural history.
The SLE Conundrum: A Comprehensive Analysis of Pathogenesis, Recent Developments, and the Future of Therapeutic Interventions
Authors: Sharma Uddeshya
Published: April 2024

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder with multifactorial interactions among various susceptibility factors. Significant strides have been made in understanding the pathogenesis of SLE, leading to the development of targeted therapies and the exploration of alternative treatments. The approval of new therapies has expanded patient treatment options, and ongoing clinical trials promise to enhance the treatment landscape further. The future of SLE treatment lies in personalized, targeted therapies that minimize side effects and improve patient outcomes. This review comprehensively analyzes SLE's current status and prospects based on recent studies, patents, clinical trials, and formulations. Continued research and clinical trials are crucial to uncovering new therapeutic options and ultimately transforming the treatment landscape for SLE. With sustained efforts and advancements in medical science, we can offer a better quality of life and improved survival rates for SLE patients.
La República de Los Indios:  Tlaxcala, Survival, and the Struggle for Autonomy within New Spain,  1519-1558.
Authors: Ocon Daniel
Published: April 2024

This thesis examines the strategies Tlaxcalan leaders employed to maintain their autonomy directly with the Spanish colonizers and administrative officials in their province in the 16th century. Previous scholarship has portrayed the Tlaxcalans as insignificant collaborators or willful allies of Spanish colonizers. This thesis, by contrast, shows that they maintained their autonomy through their strategic appeals to various colonial authorities, integration of Catholicism into native culture, and the use of both prestige and alliance to emphasize the importance of the province. This thesis uses contemporary annals, government records, literature, artwork, and letters created by the Tlaxcalans, and Spaniards, to analyze the methods and reasonings behind their adaptations.
Советская повседневность: исторический и социологический аспекты становления. 2-е изд.
Authors: Орлов Игорь
Published: April 2024

В монографии раскрыты основные аспекты советской повседневности в контексте ускоренной и неорганичной модернизации страны. Мир советской повседневности реконструирован в книге по ведущим параметрам: бытовое обслуживание и бытовые практики, производственный опыт и трудовые отношения, досуг и активные формы отдыха, семейный опыт и семейные стратегии, «бытовой этатизм» и проч. Реконструктивные возможности исследования существенно расширены благодаря широкому использованию ранее не известных научной общественности материалов ведущих российских архивов. Применение микроисторического подхода и инструментария устной истории помогли в исследовании таких малоизученных сторон советской повседневности, как практики элементарного выживания в обычные и форс-мажорные периоды российской истории. Использованные в ряде разделов монографии материалы социальной статистики обеспечили возможность перехода от микросреза к макроизмерению советской повседневности. Приведены авторские концепции места и роли сервиса в советской повседневности, специфики массового туризма как особой формы повседневности и коммунальной квартиры как специфического социокультурного феномена. Для преподавателей и студентов гуманитарных факультетов по специальностям «история», «социальная антропология», «культурология», «социология» и «политология», а также для широкого круга читателей, интересующихся повседневной жизнью россиян XX столетия.
Control of the parameters of the surface layer of steel parts during their processing applying the material homogeneity criterion
Authors: Yaroslav Kusyi , Vadym Stupnytskyy , Olha Kostiuk , Onysko Oleh , Dragašius Egidijus , Baskutis Saulius , Chatys Rafał
Published: April 2024

The main goal of the presented research is to assess the technological damageability of the material, which can be used as a criterion for analyzing the technological route of product machining in the "blank-workpiece-final part" technological chain. This technological chain is examined in detail in the most important stages of the life cycles of mechanical engineering products in order to take into account the principles of technological inheritability of their characteristics and quality parameters. The technological inheritability of the properties of the surface layers of machines and mechanisms parts from steel during their machining evaluates and predicts the transformation of the structurally heterogeneous material obtained after the production of blanks into the structurally homogeneous material of the final parts. The procedure for evaluating the homogeneity of the processed material for each technological step by the LM hardness method is presented. The developed methodology was implemented and proven during the manufacturing process of the conveyor belt drive drum shaft.
Advanced Sparse Filtering-Based Domain Adaptation for Fault Diagnosis in Variable Working Conditions
Authors: Zhou Ziyou , Chen Wenhua , Ma Jian feng
Published: April 2024

Traditional domain adaptation (DA) methods often encounter challenges with cross-domain feature extraction and the precise assessment of domain differences. To overcome these limitations, we introduce the Enhanced Sparse Filtering-Based Domain Adaptation (ESFBDA) method. This method distinguishes itself by enhancing sparse filtering (SF) with the integration of row-column normalization and a cosine penalty, specifically designed to minimize feature loss—a critical issue in existing DA techniques. Additionally, we employ Bootstrap resampling to refine domain distribution alignment, a novel step that boosts feature similarity and effectiveness in DA. This integrated approach ensures more accurate feature extraction, which is crucial for the classifier's fault detection capability. In our study, through two distinct experiments on Electro-Hydrostatic Actuator (EHA) internal leakage and bearing fault diagnosis, the ESFBDA method demonstrated remarkable accuracy, significantly surpassing traditional approaches and showcasing its robust applicability across varied diagnostic scenarios.
Development of modular cleaning complexes water of the north crimea canal for watering agricultural crops
Authors: Teplykh Svetlana Yu. , Kotovskaya Elena E. , Gorshkalev Pavel A. , Gaydaychuk Maxim G.
Published: April 2024

In the market of equipment for irrigation of agricultural crops, a significant number of imported filters are sold at a fairly high cost, the loading of which requires constant regeneration and periodic replacement. With the resumption of water supply through the North Crimean Canal and thanks to government investments in agriculture of the Republic of Crimea, the development of compact filtration structures designed to purify irrigation water is relevant.
Humidity regime of building envelope structures of the drying compartment tula brewery
Authors: Vytchikov Yuri S. , Saparev Mikhail E. , Chulkov Aleksandr A. , Konyakina Dar’ya D.
Published: April 2024

The article presents the results of a study of the humidity regime of building enclosing structures of the drying department of the brewery located in Tula. The assessment of the humidity regime was carried out in order to identify the causes of damage to external, internal walls and attic floors, and the task was also set to develop technical solutions for steam and waterproofing of the above-mentioned enclosing structures. To solve the tasks set, thermophysical calculations of building enclosing structures were performed, as well as an assessment of their moisture accumulation during the operation of the building. The position of the plane of possible condensation was determined using the author’s methodology. The results of thermophysical calculations showed the presence of moisture accumulation in the above-mentioned structures, which is associated with the use of PVC polyethylene film as wind protection. It was also revealed that there was a discrepancy with the regulatory requirements for thermal protection of the external wall of the electrical panel. In order to eliminate these problems, recommendations were made, which consisted in using an Isospan A type film as a vapor barrier, increasing the thickness of the insulation, organizing natural supply and exhaust ventilation of the attic room, as well as waterproofing the structures of the outer wall made of monolithic reinforced concrete.
Determination of operating temperature in main generator of a two-stage absorption refrigeration machine working on an aqueous solution of lithium bromide
Authors: Al Gogo Feras , Zelentsov Danila V.
Published: April 2024

This paper examines the thermal characteristics of a two-stage absorption refrigeration machine. When carrying out a numerical analysis, it turned out that the secondary generator’s temperature was not constant, and it was also found that the coefficient of thermal performance of this cycle increased significantly at the beginning, then stabilized at a certain value for the temperature degree of the primary generator. But this result is not the right value for calculating the absorption refrigeration cycle; it might cause crystallization inside the cycle and This was verified based on the thermodynamic relationship chart (h-X-T) for LiBr-water solution. In addition, the decisive point for determining the appropriate temperature is to study the change in refrigeration capacity in the process when the temperature of the generator changes. In this case, the design temperature for the primary generator should be in the range between the temperature corresponding to the highest refrigeration capacity and the temperature far from the crystallization phenomenon.
Influence of concentration of causid sodium solution on the structure formation of cement matrix from flow dust from mineral wool production
Authors: Fedorov Pavel A. , Sinitsin Dmitry A. , Shagigalin Gazinur Yu.
Published: April 2024

One of the ways to utilize mineral wool production waste is to use it in an alkaline hydraulic binder. However, this requires an assessment of the structure of the raw material and the effect of the alkaline activator on it. The article presents the results of a study of the influence of caustic soda solution concentrations of 5,6,7,8,9,10 mol/l on the properties of a cement-sand solution from dust-flying gas purification system of a cupola furnace of mineral wool production. The features of the formation of a cement matrix with changes in concentration have been studied. The maximum compressive strength of 28 MPa and flexural strength of 7.1 MPa were obtained at a concentration of 6 mol/l. It has been established that when dust is mixed with water, the mineral calcium silicate hydrate – gismondine – is formed. During the geopolymerization reaction, gismondin is significantly reduced due to the formation of N-A-S-H gel and ziolites.
Connection between the artistic design of form in architecture and design and laws of psychology and physiology of perception
Authors: Rakov Anton P. , Potemkina Yana Ev.
Published: April 2024

Specialists who have ever been involved in compositional work could not help but notice that there is a connection between compositional methods and techniques (architects, designers and artists use them in their work) and the fundamental tools of perception that nature has endowed man with and which he uses. The direction of Gestalt psychology is of greatest importance for the chosen topic. This direction describes and studies integral structures that, in principle, cannot be derived from the components that form them. At the same time, the theory of composition studies such laws of construction of a work of art that ensure the integrity of this work. It is quite obvious that the process of creating an attractive form simply must be built according to the laws of perception that are laid down by nature. It is this interesting connection that this article is devoted to.
From museum to postmuseum. Immersive environment as a metaspace of a polyloge
Authors: Shlienkova Elena V. , Kaygorodova Khristina V.
Published: April 2024

The article continues the research of the principles of museum design, which was devoted to such phenomenon as “protomuseum – immersion – spectator” and the visual nature of immersiveness and the spatial and sensory experience of its living. At this stage, attention is paid to the following typology of museumified environments: museum-at-the-crossroads (Modern times/ museum-theater, museum without walls, virtual museum, etc.) through the transition from “museum – techno-immersiveness – spectator” to “postmuseum – immersiveness – non-spectator”. The evolution of digital surfing and the construction of interactive strategies, the conflict of technological immersiveness and the cognitive properties of the viewer’s psyche are considered: what happens to him inside and outside the digital environment? Particular attention is paid to the narrative immersiveness and the role of the museum in the implementation of new “ritual” and “game” practices that can compete with the philosophy of downshifting in an attempt to get out of digital reality, return to the viewer the most important sense of “proprioception” and presence in the moment.
COVID-19'un Gebelikte Kaygı ve Prenatal Bağlanma Üzerine Etkileri: Bir Vaka Kontrol Çalışması
Authors: Türk Düdükcü Figen , Kurt Sezer Hilal , Alp Elifsena Canan
Published: April 2024

Amaç: Çalışma, COVID-19’un gebelikte kaygı ve prenatal bağlanma üzerindeki etkilerini belirlemeyi amaçlamaktadır.
Yöntem: Çalışma, kesitsel bir vaka kontrol çalışması olarak yürütülmüştür. Araştırma, Orta Anadolu'da bulunan bir tıp fakültesi hastanesinde gerçekleştirilmiştir. Araştırmada vaka grubunu 68 gebe, kontrol grubunu 69 gebe oluşturdu. Araştırma verileri Şubat 2021-Haziran 2021 tarihleri arasında Tanıtıcı Bilgi Formu, Durumluk Kaygı Envanteri ve Prenatal Bağlanma Ölçeği kullanılarak toplanmıştır. İstatistikler ortalama, standart sapma, minimum ve maksimum değerler, Pearson Korelasyon Katsayısı, Student's t-testi, One-way ANOVA varyans analizi ve Lineer Regresyon analizi olarak verildi. Anlamlılık düzeyi p
Giant congenital melanocytic nevus of the back: a case report
Authors: Idarto Areta
Published: April 2024

BackgroundGiant congenital melanocytic nevus (GCMN) is a rare disease with an extremely low incidence, that is present from or develops at birth and typically affects the dermis but may also affect other skin layers. Its incidence is estimated at <1 in 20,000 newborns. Despite its rarity, this lesion is important because it may be associated with severe complications such as malignant melanoma. A thorough follow-up is crucial since the probability of malignancy can vary depending on the clinical course. As such, careful observation is necessary to support possible management plans.
Case DescriptionIn this case report, we present a three-day-old newborn male with abrasions on a black patch on his back. He presented with fever, jaundice, and black patches on more than 50% of his trunk down to the sacral area. The black raised patches resembling nodules had wounds on the lower back near the gluteus. A histopathology examination of specimens taken from 3 nodules on the back revealed hypocellular tissues with lymphocytes, histiocytes, neutrophils, fat droplets, and mature fat cells interspersed with some erythrocytes. The lesion was, therefore, diagnosed as a giant congenital melanocytic nevus (GCMN). Parents were counseled regarding the possible future course and were asked to come for regular follow-ups.
Conclusions In this instance, we document a rare occurrence of GCMN that warrants recognition and appropriate treatment. To accumulate evidence for improving disease prognosis and outcomes, children with congenital melanocytic nev
Nicotine reduces cell viability and induces oxidative stress in human gingival fibroblasts
Authors: Azmi Sabrina , Hadi Restu Syamsul , Kusuma Indra , Suciati Yulia , Sari Wening
Published: April 2024

BackgroundNicotine, as the main component of cigarettes, is known to interfere with the proliferation of human gingival fibroblasts (HGFs) and can trigger oxidative stress. This study aimed to analyze the impact of nicotine on viability, expression of the antioxidant Nrf2, levels of the product of oxidative stress malondialdehyde (MDA), and the migration capacity of HGFs.
MethodsAn experimental laboratory study used fibroblasts isolated from healthy human gingiva. The cells were grouped into the non-treatment control group (NTC), the solvent control (SC), and the treatment groups, exposed to nicotine at various concentrations for twenty-four hours. Cell viability was assesed using the cell counting kit-8 (CCK-8), Nrf2 expression was examined using ELISA, MDA level was measured using an MDA kit, and migration capacity was assessed using a scratch assay. Statistical analysis used one-way Anova or Kruskal-Wallis test. A p-value of <0.05 was expressed statistically significant.
ResultsThe Cell viability was substantially reduced in the nicotine group compared to the untreated group, accompanied by changes in cell morphology. In contrast, Nrf2 expression increased significantly (p=0.010) in the 5 mM nicotine group compared with the control group. The MDA levels were not significantly distinct across groups (p=0.056). Cell migration was delayed significantly in the 5 mM nicotine group at 72 hours after scratching compared to the control group.
ConclusionNicotine decreased HGFs viability and increased Nrf2 expression significantly in a dose-dependent manner. Nicotine at 5 mM concentration did not alter MDA levels but delayed cell migration.
Assessing patient safety implementation and its associate factors in a pediatric inpatient ward
Authors: Rukmini Rukmini , Qomariah Siti Nur , Savage Eileen
Published: April 2024

BackgroundPatient safety is an emerging healthcare discipline with the ultimate goal of reducing errors and harm to patients by implementing quality health services. The provision of patient safety is complex and difficult to achieve. The purpose of this research was to assess patient safety in hospital pediatric inpatient care and factors affecting nurses implementing pediatric patient safety.
MethodsThis cross-sectional study involved 80 nurses (male and female) at several private and public hospitals in Surabaya City. The research instruments used were secondary data on patient safety in hospital pediatric inpatient wards, hospital medical records, as well as questionnaires, and observations of the implementation of pediatric patient safety goals. Data were analyzed using multiple logistic regression.
ResultsMost participants were female (71.3%), were over 45 years old (18%), and had more than 5 years of work experience in pediatric wards (76%). There were reportedly 145 patient safety incidents, consisting of 46% unexpected events (Kejadian Tidak Diharapkan), 48% nearly injurious events (Kejadian Nyaris Cedera), 6% potential injurious events (Kejadian Potensial Cedera), and 0% sentinel events. Multiple logistic regression analysis showed that nurses who work in less positive working settings are at higher risk of negative implementation of pediatric patient safety than those who work in positive working settings [AOR= 1.85 (95% CI 1.62-4.92)].
ConclusionThis study demonstrated that work setting and frequency of reported events were significantly associated with negative implementation of pediatric patient safety. Therefore, intervention is recommended to minimize unnecessary pediatric patient harm.
Exposure assessment and micronuclei induction in populations exposed to electronic waste in South-West Nigeria
Authors: Igharo Osaretin Godwin , Akpata C.B.N. , Aikpitanyi-Iduitua G. A. , Oshilonyah L. U. , Ola-Davies O.E. , Anetor J. I.
Published: April 2024

BACKGROUNDInformal electronic waste (e-waste) reprocessing in Nigeria is reportedly substantial in Africa, putting the growing exposed population at high risk of metal toxicity. This study aimed to investigate the existence of chromosomal aberration in the growing e-waste exposed populations in Nigeria, using induction of micronuclei (MN) expression in peripheral blood as an indicator.
METHODSIn this cross-sectional study, 632 consenting participants were recruited from South-West Nigeria, consisting of 381 e-waste workers (EWW), 120 environmental e-waste exposed participants (EEP) and 131 age-matched unexposed participants (UP) serving as controls. A validated structured questionnaire was used to assess exposure pattern while frequency of micronucleated polychromatic erythrocytes (MNPCE)/1000PCE in peripheral blood film was determined by modified micronucleus assay.
RESULTSA duration of exposure of ³5 years and exposure frequency ³6 hours/day; 6 days/week (9360 hours in any 5-year duration) was observed in both EWW and EEP. Routes of exposure observed in EWW entailed eyes, oral cavity, nasal cavity and skin. EWW that used personal protective equipment (PPE) while working was barely 10.24% while non-PPE users constituted the majority (89.76%) of the studied population. Frequency of MNPCE)/1000PCE in EWW (22.70 ± 0.15) was significantly higher than in EEP (4.17 ± 0.28), which in turn was significantly higher than the lowest frequency (0.99 ± 0.76) observed in UP (p<0.001).
CONCLUSIONThe observed exposure pattern and the comparatively higher MN induction in the e-waste populations may suggest risk of significant cytogenetic damage and aberrant chromosomal changes associated with occupational e-waste reprocessing in Nigeria.
Self-esteem as a risk factor of anxiety in senior high school students
Authors: Pratama Yoga Rizky , Tjhin Purnamawati
Published: April 2024

BackgroundAdolescence is a dynamic period of significant physical, emotional, and cognitive development, where individuals shape their identities and influence their mental health. Being vulnerable to various risk factors, including anxiety, adolescents often face mental disorders that can affect their overall well-being. With anxiety being a major concern in the global context as well as in Indonesia, this study aimed to determine self-esteem as a risk factor of developing anxiety among senior high school students.
MethodsA cross-sectional study was conducted involving 162 senior high school students, using proportionate stratified cluster simple random sampling. Data were collected through the Rosenberg Self Esteem Scale and the Hamilton Anxiety Rating Scale questionnaires to measure self-esteem and anxiety levels, respectively. The full score for self-esteem was 10–40 points. The higher the score, the greater the self-esteem. Data was analyzed using multiple logistic regression.
ResultsThe research findings indicate that adolescents experiencing anxiety amount to 51.9% and most of them indicated high self-esteem (61.1%). Multiple logistic regression test showed that low self-esteem (OR=2.21; 95% CI: 1.15-4.24) was the most influential risk factor of anxiety. However, there were no significant associations between anxiety and demographic factors such as gender, grade level, major of study, and parental income.
ConclusionMost senior high school students experience anxiety, and lower self-esteem was the most influential risk factor of anxiety. The findings highlight the need for targeted interventions to boost self-esteem as a preventive measure against anxiety among senior high school students.
Macrophage modulation in activation process induced immune thrombocytopenia
Authors: Mahdaleny Mahdaleny , Bustami Arleni , Iswanti Febriana Catur
Published: April 2024

The immune system operates like an orchestra that harmoniously maintains the homeostasis balance while protecting from external or internal pathogens attack. Inflammation is one of the key critical immune defenses to eradicate pathogens and encourage tissue repair and recovery by activating the host’s immune and non-immune cells. As a part of the immune response during inflammation, blood platelets serve various functions; however, their activation and involvement in inflammation can also contribute to pathological conditions, such as thrombosis, which results in myocardial infarction, stroke, and venous thromboembolism. Activated platelets can mobilize and release intracellular granules (alpha and dense granules), which include secondary mediators like chemokine PF4/CXCL4. In contrast to most other chemokines, PF4 participates in several long-term regulatory processes, such as cell differentiation, survival, and proliferation. However, recent findings suggest that PF4 is also responsible for modulating macrophage polarization, which can substantially impact the development of induced immune thrombotic thrombocytopenia. This review aims to explain how PF4 induced vascular problems by modulation of macrophage development during immunological thrombocytopenia. A literature search using the keywords PF4, CXCL4, macrophage M4, platelet macrophage M4, and induced immune thrombocytopenia was done using the following databases: Google Scholar, ProQuest, ScienceDirect, and Scopus for articles published from 2000 to 2023. The literature study was done to find the connection between platelet activation, macrophage modulation, and vascular problems such as atherosclerosis and thromboembolism in induced immune thrombotic thrombocytopenia. Several recent studies on PF4, macrophage modulation, and vaccine-induced thrombotic thrombocytopenia were carefully reviewed. This review concludes that macrophage polarization modulation is promising in managing vascular problems in patients with induced immune thrombotic thrombocytopenia.
Evaluation Effect Dexamethason and Paracetamol Post-Odontectomy 38 with Impaction IA Mesioangular
Authors: Musyrhifatun Baiq Kholida , Lutfianto Muhammad Bakhrul
Published: April 2024

Introduction: Impacted teeth are a pathological situation where a tooth cannot or will not erupt into normal functional position. Odontectomy is one of the most frequently performed procedures and an invasive procedure that involves extensive tissue trauma and a considerable postoperative inflammatory response. However, to achieve adequate pain relief, monotherapy is difficult and multimodal analgesia is now accepted as the cornerstone of effective pain treatment. Objective: This case report was written with the aim of evaluating the effects of dexamethasone combined with paracetamol in post-operative patients. Case Report: A 24 year old male patient came complaining that his lower left, rearmost teeth often had food stuck in them and were difficult to clean. Patient complaints since 1 year ago and said it was difficult to clean the area even with a toothbrush. The patient wants the tooth to be removed immediately. On objective examination, there were 38 mesioangular impacted teeth with percussion (-), palpation (-), sondation (-), and vitality (+). On supporting examination, it could be seen that there was 38 class IA mesioangular impacted teeth. Result: An odontectomy was carried out on the impacted tooth 38 with a trapezium flap design and post-operative medication was given in the form of amoxicillin, dexamethasone, paracetamol and multivitamins. Control after 7 days of odontectomy to see the effectiveness of the medication given. Conclusion: The use of corticosteroids in the form of dexamethasone combined with paracetamol provides a shorter edema effect and adequate pain relief after surgery
Evaluation of Root Canal Treatment in Chronic Periapical Abscess of Central Incisor
Authors: Mariza Yely Okta , Utami Hartanti Putri
Published: April 2024

Introduction: trauma to the maxillary anterior teeth is often encountered, especially in teenagers. Severe trauma can result in pulp death and even periapical lesions if left untreated. This case report aims to evaluate periapical lesions in root canal treatment with anterior tooth fractures. Case report: A 21-year-old man came to RSGM UMY with complaints of a broken left front tooth. Teeth have been broken since early high school, around 16 years old. Clinical examination showed tooth 21 an Ellis class II fracture with caries in the fracture area in the mid and distal teeth. Apart from that, there was a vesicular lesion on the mucosa parallel to tooth 21 at 5 mm above the gingival margin, which was painless. Based on radiograph examination, a fracture of 1/3 of the crown is visible, there is a periapical lesion with a lesion size of approximately 5 mm, the lamina dura and periodontal ligament are broken in the apical 1/3. Case management: Root canal treatment was performed on tooth 21 to eliminate or reduce bacteria in the root canal. The sealer for treatment uses eugenol based. Results: The results showed that there was a significant change in the apical lesion at the beginning of the visit until the second control was carried out. Conclusion: Adequate root canal treatment can cure periapical lesions and bone regeneration in cases of chronic periapical abscess
The Effect of Indirect Pulp Capping Treatment on Oral Health Quality of Life at The Dental Hospital Universitas Muhammadiyah Yogyakarta
Authors: Puspita Sartika , Aristiyanto Regia , Utami Sri , Kusumawati Nabiilah Budi
Published: April 2024

Background: Dental and oral health-related quality of life is an individual's assessment of the impact of oral disorders that can affect the overall quality and well-being of their lives. One of the oral disorders that is frequently experienced by the community is pulpitis, which, if left behind, can cause pain and cause the tooth to become necrotic. Indirect pulp treatment can be done to deal with pulpitis and improve the patient quality of life. The study aims to determine the impact of indirect pulp capping treatment on quality of life based on gender, age, educational level, and number of teeth treated. Methods: The data collection technique in this study uses primary data in the form of a questionnaire and secondary data, which is data from the medical records of patients performing pulp capping treatment. The sample in this study is a patient who has completed indirect pulp capping treatment in the dental hospital UMY. The data analysis used in this study is descriptive analysis as well as chi square tests and controls to test the hypothesis. The results of this study are patient gender, the education level, and the number of teeth treated have no influence on quality of life related to oral health (p>0.05) otherwise the patient age has an influence on quality of life related to oral health (p<0.05). Conclusion: Gender, education level, and number of teeth treated have no influence, while age has an influence on quality of life