bluuebunny/crossref_metadata_2025 huggingface dataset:
Formulation of Special Pythagorean Triangles through Integer Solutions of the Hyperbola 𝑦𝟐 = (𝑘𝟐 + 𝟐𝑘)𝑥𝟐 + 𝟏
Authors:   Assistant Professor, Department of Mathematics, Shrimati Indira Gandhi College, Bharathidasan University, Trichy, 620002, Tamil Nadu, India, Shanthi J , Gopalan M A
Published: November 2024

Objectives: The objective of this research paper is to formulate Pythagorean triangles, each of which satisfies the relation: Hypotenuse = (𝑘 + 1) times the leg with even values added with unity, through employing the integer solutions to the Hyperbola 𝑦2 = (𝑘2 + 2𝑘)𝑥2 + 1. Methods: The sides of the Pythagorean triangle satisfying the requirement are obtained by suitably choosing its generators consisting of the integer solutions to the considered hyperbola. Findings : There are plenty of Pythagorean triangles satisfying the given characterization for each value of k > 0 in the binary quadratic equation given by 𝑦2 = (𝑘2 + 2𝑘)𝑥2 + 1.The characterizations of special pattern of the Pythagorean triangle for 𝑘 = 2is illustrated. Novelty: From the integer solutions of a binary quadratic equation, namely, a hyperbola (Two-dimensional geometrical representation), it is possible to obtain integer solutions to a ternary quadratic equation, namely, Pythagorean triangle (Threedimensional geometrical representation). Keywords: Binary quadratic equation; Ternary quadratic equation; Hyperbola; Pythagorean triangle; Integer solutions
Cyclic Voltammetry in the Spleen for In Vivo Recording of Stimulus-Evoked Norepinephrine v1
Authors: Gerber Michael , Qaiser Hassan , Mughrabi Ibrahim , Zanos Stavros
Published: November 2024

This protocol describes methodology for in vivo recording of norepinephrine concentration in the spleen of mice during a stimulus (i.e electrical nerve stimulation, drug injection, etc.). Part 1 describes the preparation of surgical and recording equipment. Part 2 describes the surgery and recording. The typical voltammetric signal for norepinephrine in the spleen is characterized in Figure 1 of the referenced manuscript. Stimulation of the splenic, splanchnic, or vagus nerves with a 10-second electrical train should illicit a rising signal that plateus in ~1min and comes back to baseline in ~1-2 minutes.
Tissue dissociation and 10x Multiome for fetal heart tissue (Version 1) v1
Authors: X Ma Rosa , D Conley Stephanie
Published: November 2024

Congenital heart defects (CHD) arise in part due to inherited genetic variants that alter genes and noncoding regulatory elements in the human genome. These variants are thought to act during fetal development to influence the formation of different heart structures. However, identifying the genes, pathways, and cell types that mediate these effects has been challenging due to the immense diversity of cell types involved in heart development as well as the superimposed complexities of interpreting noncoding sequences. As such, understanding the molecular functions of both noncoding and coding variants remains paramount to our fundamental understanding of cardiac development and CHD. Here, we created a gene regulation map of the healthy human fetal heart across developmental time, and applied it to interpret the functions of variants associated with CHD and quantitative cardiac traits. We collected single-cell multiomic data from 734,000 single cells sampled from 41 fetal hearts spanning post-conception weeks 6 to 22, enabling the construction of gene regulation maps in 90 cardiac cell types and states, including rare populations of cardiac conduction cells. Through an unbiased analysis of all 90 cell types, we find that both rare coding variants associated with CHD and common noncoding variants associated with valve traits converge to affect valvular interstitial cells (VICs). VICs are enriched for high expression of known CHD genes previously identified through mapping of rare coding variants. Eight CHD genes, as well as other genes in similar molecular pathways, are linked to common noncoding variants associated with other valve diseases or traits via enhancers in VICs. In addition, certain common noncoding variants impact enhancers with activities highly specific to particular subanatomic structures in the heart, illuminating how such variants can impact specific aspects of heart structure and function. Together, these results implicate new enhancers, genes, and cell types in the genetic etiology of CHD, identify molecular convergence of common noncoding and rare coding variants on VICs, and suggest a more expansive view of the cell types instrumental in genetic risk for CHD, beyond the working cardiomyocyte. This regulatory map of the human fetal heart will provide a foundational resource for understanding cardiac development, interpreting genetic variants associated with heart disease, and discovering targets for cell-type specific therapies.
Tissue dissociation and 10x Multiome for fetal heart tissue (Version 2) v2
Authors: X Ma Rosa , D Conley Stephanie
Published: November 2024

Congenital heart defects (CHD) arise in part due to inherited genetic variants that alter genes and noncoding regulatory elements in the human genome. These variants are thought to act during fetal development to influence the formation of different heart structures. However, identifying the genes, pathways, and cell types that mediate these effects has been challenging due to the immense diversity of cell types involved in heart development as well as the superimposed complexities of interpreting noncoding sequences. As such, understanding the molecular functions of both noncoding and coding variants remains paramount to our fundamental understanding of cardiac development and CHD. Here, we created a gene regulation map of the healthy human fetal heart across developmental time, and applied it to interpret the functions of variants associated with CHD and quantitative cardiac traits. We collected single-cell multiomic data from 734,000 single cells sampled from 41 fetal hearts spanning post-conception weeks 6 to 22, enabling the construction of gene regulation maps in 90 cardiac cell types and states, including rare populations of cardiac conduction cells. Through an unbiased analysis of all 90 cell types, we find that both rare coding variants associated with CHD and common noncoding variants associated with valve traits converge to affect valvular interstitial cells (VICs). VICs are enriched for high expression of known CHD genes previously identified through mapping of rare coding variants. Eight CHD genes, as well as other genes in similar molecular pathways, are linked to common noncoding variants associated with other valve diseases or traits via enhancers in VICs. In addition, certain common noncoding variants impact enhancers with activities highly specific to particular subanatomic structures in the heart, illuminating how such variants can impact specific aspects of heart structure and function. Together, these results implicate new enhancers, genes, and cell types in the genetic etiology of CHD, identify molecular convergence of common noncoding and rare coding variants on VICs, and suggest a more expansive view of the cell types instrumental in genetic risk for CHD, beyond the working cardiomyocyte. This regulatory map of the human fetal heart will provide a foundational resource for understanding cardiac development, interpreting genetic variants associated with heart disease, and discovering targets for cell-type specific therapies.
“Other(ed)” Ocean Knowledges: Unlearning Integration in Ocean Governance for Recognitional Justice
Authors: Champion Giulia , Strand Mia
Published: November 2024

There is an increasing call for the need to “integrate” Indigenous and local knowledge systems in ocean governance processes, on national and global scales. However, the knowledge systems, epistemes, and practices of different Indigenous and local coastal communities, whose stewardship of the planet sustains and protects marine ecosystems, pre‐date the institutionalised ocean sciences and governance with which they are meant to be integrated. The concept of integration often perpetuates othering and devaluation of various ocean knowledges that should not be subject to these problematic practices. Much of the current knowledge informing ocean governance is underpinned by colonial, military, and financial projects, in direct juxtaposition to epistemes and practices that are deeply interconnected with marine life. Writing from a marine social sciences perspective, we explore the inherent problems and limitations of integration approaches and propose reversing how we frame “knowledge” and its othering by suggesting that our scientific and governance practices are, in fact, “other” to longstanding ways of coexisting with the ocean. Without attempting to represent Indigenous knowledge systems or categorise these as unaware of scientific developments, we argue that researchers and scientists need to actively unlearn what is taught in prominent ocean sciences. By focusing on global governance through the International Seabed Authority and national ocean governance in South Africa, respectively, we explore knowledge othering and the process of unlearning what ocean governance teaches as knowledge integration to better critically consider how the ocean is, has been, and should be valued.
Exploring Elementary School Children’s Interaction at the School Threshold: Evidence From Athens, Greece
Authors: Bazaiou Natalia
Published: November 2024

The school entrance is one of the most important places in the everyday lives of children. As an intersection between school and public realm of the city, it is characterized by gradations of porous and rigid boundaries. Depending on its function, it can serve as a threshold or as a boundary. Additionally, it is a spatial condition that facilitates a dialogue between the school and the city and draws content from both. School thresholds are important in supporting the role of the school as an important node in the city and a bridge between children’s various everyday life dynamics by demonstrating meaning as a place that is open to the community as well as to possibilities and physical interaction. In this research, we examine the role of the “realm of the in-between” between school and city through the architecture workshops for children at an Elementary School in the heart of Athens, in which we explore children’s perceptions, wishes, and ideas related to their familiar everyday places of transition from school to city and vice versa. The aim of the research is to find out: (a) What is the role of school entry today? (b) What is the children’s perception of the entrance of the school? (c) What are children’s wishes in relation to the spatial transition from city to school to better meet their needs and desires? (d) What are the specific qualities of a school entry that render it an ideal space for the interaction between children and with the space around them? and (e) How does the synergy of cinematic-architectural tools feed, enrich, and open up new possibilities in understanding and representing spatial and social phenomena?
Assessing Freeze-Thaw Damage of Internally Cured Concrete Using Pre-Saturated Coal Ash Based Fine Lightweight Aggregates
Authors:   , Tejuoso Bankole , Farnam Yaghoob
Published: November 2024

This study evaluates freeze-thaw durability of internally cured concrete using pre-saturated fine lightweight aggregates (FLWA). The aggregates used to manufacture concrete include laboratory-manufactured coal combustion ash FLWA (CCA-FLWA), commercially available FLWA for performance assessment and normal weight aggregate as reference samples. Utilizing a Longitudinal Guarded Comparative Calorimeter (LGCC) and acoustic emission sensors, the research subjected these materials to a series of controlled freeze-thaw cycles to investigate the impact of varying degrees of saturation (DOS) of 100, 95, 90, 85, and 80% on their structural integrity and durability. Ultrasonic Pulse Velocity (UPV) tests were employed to measure active acoustic emissions and calculate the damage index before and after the freeze-thaw cycles, providing a quantitative assessment of each concrete types. The results indicate that the critical DOS threshold, where significant damage occurs, lies between 78-80%. Notably, CCA-FLWA demonstrated enhanced durability, requiring a longer period of 47 days to reach critical saturation, thus suggesting a lower susceptibility to freeze-thaw damage compared to Stalite-FLWA and conventional concrete. This study underscores the importance of material selection in environments prone to freeze-thaw cycles and highlights the potential of using sustainable aggregates to improve concrete durability. The findings contribute to the field of civil engineering by providing insights into the behavior of alternative concrete materials under adverse environmental conditions. Examining the data, the control concrete exhibited the highest cumulative energy values, with an average of 1.95x10⁷ eu at 100% DOS, suggesting significant internal damage. The Stalite-LWA concrete showed lower cumulative energy, averaging 1.65x10⁷ eu at 100% DOS, indicating better resistance compared to the control. However, the CCA-FLWA concrete had the lowest cumulative energy, with an average of 5.14x10⁵ eu at 100% DOS, underscoring its superior durability.
Karakteristik Rempah dan Tantangannya Dalam Pengembangan Bumbu Basah Instan: Sebuah Review Singkat
Authors: Rezeki Kartika Sri , Candra Krishna Purnawan , Saragih Bernatal
Published: November 2024

Seasonings are various plant products with a fragrant aroma, such as galangal, turmeric, ginger, cinnamon, nutmeg, and pepper, and are used to flavor dishes. A more practical lifestyle and an increasing culinary industry have led to the development of the culinary industry to open business opportunities for processing instant wet spices to shorten cooking time. Instant seasoning is a mixture of various spices and seasonings that are mashed and processed into one. Instant seasoning processing requires safe and healthy handling, including freedom from pathogenic microbial contamination. Even though the spices have various functional activities including antibacterial, the development of instant wet seasonings is still facing a handicap of its microbiology safety. A broad contamination of bacteria, yeast and mold are still detected in the instant wet seasoning.
Ekstraksi Komponen Fenolat dari Liang Teh Pontianak Perisa Jahe Secara Partisi
Authors: Nada Geri , Dewi Yohana Sutiknyawati Kusuma , Fadly Dzul
Published: November 2024

Liang Teh Pontianak (LTP) is one of the beverages traditionally consumed as a functional drink. Liang teh is an herbal drink composed of various plant ingredients including secang stem bark, muje leaves, nanas kerang leaves, oregano leaves, pandan leaves, and lidah buaya mid rib, which known for their medicinal and health benefits. The aim of this study was to identify the phenolic components of ginger-flavored LTP through partition extraction. The plant materials were processed into powder and formulated to a total of 21 grams, consisting of 10 g of muje leaves, 1 g of oregano leaves, 1 g of aloe vera mid rib, 2.5 g of nanas kerang leaves, 4.5 g of secang stem bark, 1 g of pandan leaves, and 1 g of ginger as the tea flavor. The mixture of Liang teh powder then partitioned using various solvents in order of increasing polarity, namely n-hexane, ethyl acetate, ethanol, methanol, 70:30 methanol-water (v/v) mixture, and water. The research results showed that extracts from all solvent types contained alkaloids, phenols, flavonoids, and tannins. The highest yield was obtained from the ethanol extract (6.10±0.35) %, while the highest antioxidant activity was found in the methanol extract (84.43±1.38) %.
Penilaian Penerapan Good Manufacturing Practices (GMP) pada Proses Produksi Dimsum (Studi Kasus : UMKM XYZ)
Authors: Arpi Normalina , Eliza Tasya , Aisyah Yuliani
Published: November 2024

Dimsum is a high-risk food category because it uses basic ingredients of chicken meat and these ingredients have a water content of around 65-80% and a high pH of around 6-7, as well as easily degraded and easy to grow microorganisms. This study aims to assess the application of GMP in the production process in Aceh Dimsum Micro, Small and Medium Enterprises (UMKM) and the application of GMP is the basic requirement for granting a distribution permit certificate for the Deep Food (MD) category by the Food and Drug Supervisory Agency (BPOM). In this study, the assessment of the application of GMP in dimsum production process was carried out using the Gap Assessment method by assessing the suitability and non-conformity of the GMP aspects applied. The assessment is carried out by giving value weight to the finding of nonconformity based on the category of nonconformity. From the results of the research that has been carried out, conformity findings, nonconformity findings, and GMP aspect findings that are not applied to the production process are obtained. There are 17 points of conformity findings applied from 12 aspects of GMP. There were 51 points of nonconformity findings found from 21 aspects of GMP. There are 2 points of aspects that do not apply or are not used to UMKM from 2 aspects of GMP (aspects of internal testing laboratories and aspects of water, ice, gas and energy (electricity, fuel). Based on the amount of value weighted obtained from the findings of nonconformity, the score obtained by UMKM is around a score of 78. Based on this score, the level (rating) of UMKM is rating D. The conclusion that can be drawn is that UMKM need to make improvements to the discrepancies found in the production process.
Pengembangan Alat Ukur Kolestrol Secara Non-Invasive untuk Diagnosis Medis
Authors: Nurqaidah Siti , Amanda Ryan , Ariansyah Tegar
Published: November 2024

Perkembangan teknologi telah memberikan kontribusi besar di bidang kesehatan, salah satunya dalam pengukuran kadar kolesterol. Metode pengukuran kolesterol yang umumnya digunakan adalah invasif, yang memerlukan pengambilan sampel darah. Namun, metode ini memiliki beberapa kekurangan, seperti rasa nyeri dan biaya yang tinggi. Oleh karena itu, penelitian ini bertujuan untuk mengembangkan alat ukur kolesterol secara non-invasive yang dapat mengurangi kekurangan tersebut. Penelitian ini menggunakan metode Research and Development (RD), yang difokuskan pada pengembangan produk dan pengujian efektivitasnya. Alat yang dikembangkan bekerja dengan mengukur kadar kolesterol yang memanfaatkan sinar cahaya untuk mendeteksi perubahan pada darah tanpa memerlukan pengambilan sampel. Hasil penelitian menunjukkan bahwa alat yang dikembangkan mampu mendiagnosis kadar kolesterol dengan tingkat akurasi sebesar 95,3%, dengan persentase kesalahan sebesar 4,7%, alat ukur kolesterol non-invasive ini dapat berfungsi sesuai dengan perencanaan, dapat menjadi alternatif yang efektif dan nyaman untuk pengukuran kolesterol di masa mendatang.
Analysis of positive predictors in diagnosing lung cancer on transthoracic and transbronchial procedure
Authors: Tandibua Desy Irene , Candrawati Ni Wayan , Kusumawardani Ida Ayu Jasminarti Dwi , Sajinadiyasa I. Gede Ketut , Arisanti Ni Luh Putu Eka , Krisdanti I. Desak Putu Agung
Published: November 2024

Background: Lung cancer remains the most cause of death due to cancer. Due to high mortality rate of lung cancer, early diagnosis of lung cancer plays a very important role in therapeutic management. Clinical symptoms and tumor characteristics such as size and location are found to vary in lung cancer patients. Various modalities can be used to obtain materials or samples include transthoracic and transbronchial methods. Research was conducted to analyze positive predictors of cancer between transthoracic and transbronchial procedures in lung cancer patients.
Methods: This research is an analytical observational study with a cross-sectional design in using secondary data through medical records from January 2022 to December 2023. Univariate analysis presents data in the form of frequency, mean and standard deviation. Bivariate analysis was carried out using chi-square and multivariate analysis using multiple logistic regression. The measure used as a predictor is the adjusted odds ratio. Inference or conclusion is based on the 95% confident interval and p value at the alpha value limit of 0.05. The entire data process above uses SPSS 26.0 statistical software
Results: The total research subjects who met the research requirements were 111 patients. The characteristics of the research subjects were symptoms of cough (n=97; 87.4%), hemoptyisis (n=51; 45.9%), breathlessness (n=104; 93.7%) and chest pain (n=87; 78.4%), mostly peripheral tumor (n=70; 63.1%) and size >3 cm (n=103; 92.8%). Logistic regression analysis showed cough symptoms and peripheral tumor location each had an adjOR value of 5.247 (95% CI 1.432-19.552; p=0.013) and adjOR 0.088 (95% CI 0.034-0.229; p=0.000) for lung cancer positivity on transbronchial procedure. On transthoracic procedure, cough symptoms and peripheral tumor location respectively had an adjOR value of 0.190 (95% CI 0.051-0.703; p=0.013) and adjOR 11.407 (95% CI 4.374-29.747; p=0.000) for lung cancer positivity.
Conclusions: Cough is a positive predictor of lung cancer in transbronchial procedures. Meanwhile, peripheral tumor location is a positive predictor of lung cancer in transthoracic procedures.
Advantages and disadvantages of a closed-loop economy: the path to environmentally friendly production
Authors: Ishin Leonid A. , Cherepovitsyn Alexey E. , Lebedev Andrey P.
Published: November 2024

The relevance of the study is related to the development of the circular economy in the national economies of many countries of the world, where it is receiving increasing attention. Circular technological and economic models can be considered promising areas of strategic transformation for companies that contrast themselves with traditional business models of an open economic system based on extensive growth. The concept of a circular economy appeared in order to create closed-loop production and consumption models that aim to increase resource efficiency, use waste management approaches and achieve stable coexistence between the economy, the environment and the population. The purpose of the study is to analyze relevant scientific sources and statistical information to determine the advantages and disadvantages of closed-loop economic models at the current stage of scientific and technological progress. The research methodology is based on the use of general scientific research methods such as analysis, generalization, abstraction, synthesis. The results of the study. The article evaluates the current situation of the development of the circular economy in the world, identifies factors that emphasize the extensiveness of the current economy. The main advantages, disadvantages and barriers of the circular economy are presented, classified into four aspects: environmental, economic, technological and social. It is established that from the point of view of the economic development of the branches of the national economy, the circular economy will create new markets and business opportunities in the sectors of recycling and servicing of goods. It is also assumed that circular business models can increase the competitiveness of companies through innovation and optimization of production processes. In addition, circular economic systems will contribute to the development of innovative technologies and processing methods aimed at more efficient use of raw materials and materials.
Development of a Mathematical Forecasting Model RUONIA
Authors: Bogatyrev Vladimir D. , Rostova Elena P.
Published: November 2024

The article examines the time series of dynamics of the RUONIA indicator, the key rate of the Bank of Russia, money supply, inflation for the period from January 2010 to the present time. During the study, methods of correlation analysis were used, as well as time series analysis, multicollinearity was checked, and autocorrelation was identified. The developed model for forecasting the value of RUONIA is based on the value of the current key rate of the Bank of Russia, the dynamics of the money supply, as well as the previous value of RUONIA. The model allows you to “predict” the value of RUONIA in order to make more informed financial decisions.
The main trends of advanced scientific and technological development of Russian industry
Authors: Anisimova Valeriya Yu.
Published: November 2024

The article presents the results of a practical assessment of the results of development of the national economy of the Russian Federation, expressed in the main trends of advanced scientific and technological development of the country’s industry. The study notes the importance of the industrial sphere for acquiring national technological sovereignty. In order to reduce import dependence on foreign suppliers, the current trends of advanced scientific and technological development of industry and its place in ensuring national security of the Russian economy are considered. The main indicators of the production index in high-tech industries are studied in conjunction with a comprehensive assessment of the used and developed advanced production technologies. The author of the study proposes a modernized model for managing the process of advanced innovative import substitution.
Stochastic model of the influence of the dynamics of innovation potential on the transformation of a manufacturing enterprise
Authors: Aksinin Vladimir I. , Saraev Leonid A.
Published: November 2024

The published article presents the development of a stochastic model of the dynamics of development of a multifactor manufacturing enterprise, taking into account the influence of interaction of product and process innovative potentials. To form the balance of the enterprise, a system of stochastic differential equations is established for the volumes of all its resources. Management of the processes of stage-by-stage implementation of innovative potentials in production is carried out by special indicator functions included in the system of stochastic differential equations, which set time intervals for the deployment of innovative potentials. The limiting values ??of the volumes of enterprise resources and the volume of output are calculated. Numerical solution of the system of stochastic differential equations of the developed model allows us to obtain stochastic trajectories and curves of mathematical expectations of the volumes of production factors and output volumes.
Przeciwdziałanie oszustwom inwestycyjnym typu piramida finansowa i schemat Ponziego
Authors: Lesiak Magdalena
Published: November 2024

Celem artykułu jest identyfikacja podobieństw i różnic oraz prezentacja obecnych rozwiązań regulacyjno-nadzorczych w Polsce dotyczących zwalczania oszukańczych praktyk o cechach piramidy finansowej i schematu Ponziego. W Polsce penalizacja oparta jest na kilku odrębnych aktach prawnych. W przeciwieństwie do niektórych krajów europejskich nie została wprowadzona w obecnym porządku prawnym odrębna kategoria przestępstwa, jakim jest organizowanie oraz prowadzenie działalności typu piramida finansowa i schematu Ponziego. Ze względu na wielkość strat ekonomicznych generowanych przez tego typu oszustwa w opracowaniu zaproponowano wprowadzenie do kodeksu karnego osobnego typu oszustwa, mającego znamiona piramidy finansowej i schematu Ponziego, na wzór rozwiązań zastosowanych w innych krajach europejskich.
The obligation of repairing the harm for property offence in the 1983 Code of Canon Law
Authors: Kaleta Paweł
Published: November 2024

The obligation of repairing the harm is a new requirement of canon law, added to the expiatory penalty for financial offences. The study aims at clarifying the nature of the obligation of reparation of the harm, in particular whether it is an additional penalty besides the expiatory one, whether reparation of the harm replaces the expiatory penalty for financial offences in the canonical legal order. It is worth noting that the previous Book VI of the 1983 Code did not impose an obligation to repair harm arising from property offences.
The Human Life and Dignity in a Trans-humanist Context
Authors: Lăcătuș Adrian Neculai
Published: November 2024

The main scope of the paper is to analyze the human life and dignity in a transhumanist perspective. The approach we propose is a historical and analytical one. We will start from the milestones in the Greek philosophy regarding the virtues of the superior human, as was viewed in that era of mankind (what today is known in philosophy as a superhuman). After the historical analysis, we will start the analytical approach and discuss the passage from humanism to transhumanism regarding the superhuman. The discussions will focus on the concepts of divine transcendence and the pseudo-transcendence discussions, the dehumanization of man, the transformation of man into a superhuman under the influence of technology. Our conclusions are that man needs to feel protected, to feel free and to feel human, but what it means to be human is different according to the historical age we consider in the timeline of humanity.
Fotografia jako materiał badawczy między danymi wywołanymi a zastanymi
Authors: Sierakowski Marek
Published: November 2024

Przedmiotem artykułu jest wykorzystywanie w badaniach jakościowych materiału jakim jest fotografia. Jest ona nie tylko zapisem historycznej rzeczywistości czynionej przez badacza jako status quo, ale co współcześnie ważne jest rodzajem zwrotu ku obrazowi i próby jego interpretacji. Korzystając z różnych źródeł antropologicznych i socjologii fotografii, autor analizuje materiał badawczy w postaci fotografii, które zgromadził podczas prowadzenia badań terenowych na Ziemi Łowickiej. Stanowiły one ważny element przeprowadzonych wywiadów swobodnych z liderami lokalnymi. Obraz traktowany jest jako tekst kultury tworzony przez badacza i badanego w dyskursie społecznym.
Reinhardt, Schlemmer i inni. Studia i szkice o dramacie i teatrze niemieckojęzycznym
Authors: Leyko Małgorzata
Published: November 2024

Główna wartość książki leży nie tyle w oryginalności stawianych tez, ile w prezentacji nieznanych faktów i ich powiązań, w rysowaniu zapoznanego pejzażu kulturowego, którego obecność była niezwykłe ważna także dla polskiego teatru XX wieku. [...] Jest to bardzo cenna publikacja. Autorka opisuje zarówno twórczość pierwszorzędnych postaci dwudziestowiecznego teatru, wciąż słabo u nas znanych (Reinhardt Schlemmer), jak i proponuje nowe spojrzenie na zjawiska i osoby prezentowane u nas wielokrotnie (Brecht, Turrini). Ponadto ukazuje mało dotąd poznane wątki polsko-niemieckie – wczesne role Poli Negri, niemieckie interakcje Leona Schillera czy Ryszarda Ordyńskiego. Prof. dr hab. Tomasz Kubikowski
Książka składa się z trzech logicznie skomponowanych części. Pierwsza dotyczy aktywności Maxa Reinhardta jako wybitnego artysty i skutecznego menedżera. W zakres tego kręgu tematycznego wchodzą wyjątkowo cenne artykuły dotyczące kontekstów polskich. […] Drugi korpus tekstów składa się z dogłębnych analiz twórczości Oskara Schlemmera połączonych z doskonałymi opisami re-kreacji Baletu triadycznego i Tańców Bauhausu. Trzecia część ma charakter „eklektyczny” (Piscator, Wolf, Brecht, Bausch, Jonke, Turrini, Nestroy). [...] Atrakcyjność publikacji wynika z nowego naświetlenia wielu aspektów historii teatru niemieckojęzycznego oraz wprowadzenia do polskiego dyskursu naukowego działalności artystycznej takich twórców, jak Reinhardt, Schlemmer czy Gert Jonke. Dr hab. Marek Podlasiak, prof. UMK
The Role of Aquaporin in Stress Physiology: A Review
Authors: Rebez Ebenezar Binuni , Jacob Ninan
Published: November 2024

The concept of water movement across cell membranes eventually lead to identification of water channels, known as ‘Aquaporins’. The transport function exerted by aquaporins (AQPs) is carried out efficiently by 13 distinct isoforms of AQPs in mammals. AQPs help in regulation of physiological functions of various organ systems and have a functional role in stress associated with various pathological conditions. This review summarises the involvement of AQPs in transport of ROS and oxidative stress regulation in various organ systems. AQP1, AQP4, AQP7 and AQP9 are the major AQPs in the cardiac tissues of various animals, playing vital role in the patho-physiology of congestive heart failure, myocardial oedema, myocardial ischemia and polymicrobial sepsis. In digestive system, AQP1, AQP3, AQP4, AQP7, AQP8, AQP10 and AQP11 are localised in gastro-intestinal tract, modulating patho-physiology of pseudomembranous colitis, bile induced diarrhoea, irritable bowel syndrome and intestinal ulcers. AQPs in enteric tissues are engaged in metabolism of H2O2, providing a protective mechanism against oxidative stress. AQP1, AQP2, AQP3, AQP4 and AQP11 are major renal AQPs involved in ureteral obstruction, nephrogenic diabetes insipidus and kidney injury. In respiratory system, AQP1, AQP2, AQP4 and AQP5 are expressed in various pathological circumstances like lung injury and pulmonary inflammation due to oxidative stress. Thus, the evidences regarding the role of AQPs in oxidative stress offer a foundation for comprehending the adaptive mechanisms to oxidative injury at cellular level, which helps in strategizing breeding programmes and serves as biomarkers for efficient diagnosis.
Validation of Electrochemical Biosensor based Hand-held Device for the Measurement of Blood Glucose in Lactating Buffaloes (Bubalus bubalis)
Authors: Dalvi S.H. , Karambele N.R. , Tamuly Shantanu , Mundhe M.B.
Published: November 2024

Background: Bovine ketosis is a major metabolic disorder emerging as a result of negative energy balance in the post calving period and subsequent lactation of lactating dairy animals. The measurement of the concentration of blood glucose was reported to be helpful for the early diagnosis of subclinical ketosis in buffaloes. Also, blood glucose will provide the overall energy status of the buffalo. Methods: The experiment was conducted on 56 healthy lactating Murrah buffaloes. Blood samples were collected in two slots for two consecutive days in the morning hour in an anticoagulant-added sodium fluoride bulb and in clot activator plain tubes by jugular venipuncture. Also, glucose concentration was measured by a handheld device (“Gluco One”, Model BG-03) by puncturing the small branches of the ear vein and the results were recorded. The estimation of blood glucose plasma and serum was done by standard laboratory enzymatic method i.e. Glucose Oxidase- Peroxidase (GOD-POD) on an automated chemistry analyzer. Result: There was no significant difference between the mean values of plasma glucose measured by the GOD-POD method and by the biosensor. But the regression analysis showed the blood glucose in plasma do not have a significant correlation with that measured by biosensor. The glucose measured in serum is significantly less than in plasma and measured by the biosensor. It is advisable to use fluoride-added preservative anticoagulant tubes and not to use a serum for the estimation of blood glucose.
Green Synthesis and Characterization of Silver Nanoparticle from Calanthe masuca (D.DON) Lindl. Leaf Extract and Evaluation of Biological Activity - An Endangered Orchid (Orchidaceae)
Authors: Kavitha Duraisamy , Nandagopalan Veeraiyan , Deborah Seedar
Published: November 2024

Researchers looked at the therapeutic benefits and biological properties of silver nanoparticles (AgNPs) and created and tested novel eco-friendly methods to make them using an extract from the Calanthe masuca (D. Done) Lindl plant (Orchidaceae). After the C. masuca leaf extract was transformed, X-ray diffraction confirmed the existence of crystalline nanoparticles by revealing different peaks. The AgNPs were found to be spherical in shape, with a size ranging from 2 to 50 nm and a diameter of 0.500 nm, according to transmission electron microscopy, energy dispersive X-ray analysis, and scanning electron microscopy. The presence of silver nanoparticles in the synthetic leaf components was confirmed by a 428 nm absorption peak in the UV-visible spectra. Scanning electron microscopy (SEM) confirmed the nanoparticles’ size, while FTIR analysis revealed their inclusion of many functional groups. They proved their antibacterial effectiveness by producing silver nanoparticles and tested them against different human pathogenic pathogens. Staphylococcus aureus (6.5 ± 1.0 μg/ ml), Bacillus subtilis (7.6 ± 1.0 μg/ml), Escherichia coli (10.4 ± 1.0 μg/ml), Streptococcus oralis (7.6 ± 1.0 μg/ml), Aspergillus niger (9.3 ± 1.0 μg/ml), and Candida albicans 7.5 ± 1.0 μg/ml) and the high zone of inhibition were seen in Escherchia coli and Candida albican. This study demonstrates the biomaterial’s promise for use in the production of silver nanoparticles using green chemistry methodology. An ecofriendly way of generating nanoparticles is highlighted in this paper, which highlights their promising applications in biology and medicine.
Copper Oxide Nanoparticles Influenced Ionome, Reduced Growth, Altered Pigments and Stomatal Morphology in Mentha arvensis L.
Authors: Dwivedi Archana , Kumar Subodh , Vajpayee Poornima
Published: November 2024

Copper oxide nanoparticles (CuO NPs) are being enormously used in agriculture, aquaculture, textile, cosmetic, food and pharmaceutical industries. CuO NPs are reported to make their presence in soil water and air due to their release in the environment. Mentha arvensis L. (Lamiaceae) is commercially grown for essential oil across the world due to its medicinal value. The present study reports the responses of M. arvensis to CuO nanoparticles (0.0–5.0 μg mL-1) after 18 d exposure. The build-up of high copper concentrations in M. arvensis plant tissues (roots and leaves) confirms the internalization and movement of CuO NPs in shoots. CuO NPs modified ionomes of roots and leaves of M. arvensis. Both roots and leaves of M. arvensis plants exposed to CuO NPs exhibit altered levels of micro (reduced Fe, Mn, and upregulated Zn and Mo contents) and macronutrients (decreased Ca, Mg and K levels). Further, CuO NPs decreased biomass, total chlorophyll, chlorophyll a, chlorophyll b and relative water contents and increased carotenoids and anthocyanin contents in M. arvensis leaves. Besides, CuO NPs caused alteration in stomatal morphology of test plant. The present study suggests sustainable use and environmental release of CuO NPs due to their possible bio-toxic consequences.
KAKO SE I ZAŠTO (NE) NASTAVNICI ENGLESKOG JEZIKA U SRBIJI PROFESIONALNO USAVRŠAVAJU?
Authors: Farkaš Lenka I.
Published: November 2024

Fokus ovog rada je na profesionalnom usavršavanju nastavnika engleskog jezika kao stranog. Cilj istraživanja bio je sagledavanje načina na koje se nastavnici usavršavaju, formalno ili neformalno, kao i ispitivanje da li oni učestvuju u profesionalnom razvoju zbog ličnih razloga ili zahteva okoline, te zašto ne učestvuju u njemu više. Istraživanje sprovedeno pomoću upitnika bilo je kvalitativnog tipa. Rezultati su pokazali da se nastavnici radije usavršavaju na neformalne načine, poput čitanja literature ili gledanja korisnog sadržaja. Takođe, više nastavnika se usavršava kako bi bili bolji u svom poslu, nego zbog zahteva poslodavca, zakona ili studija. Zatim, nedostatak vremena zbog poslovnih ili porodičnih obaveza i nedostatak novčanih sredstava glavni su razlozi za nedostatak usavršavanja. Implikacije istraživanja leže u podsticanju nastavnika na neformalne vidove profesionalnog razvoja, čime se nastavnicima omogućava pristup brojnijim mogućnostima za lični i profesionalni razvoj, što bi posledično vodilo i ka razvoju nastavne prakse.
Assessment the bioactivity of zinc oxid eugenol sealer after the addition of different concentrations of nano hydroxyapatite-tyrosine amino acid
Authors: Al-Shamaa Rasha M. , Al-Askary Raghad A.
Published: November 2024

Aim: Zinc oxide eugenol sealer has been used till now in endodontic obturation. However, despite many improvements in its formula, it still does not have, the essential root canal sealer’s properties which is the apatite forming ability. The aim of the present study is to assess the effect of the incorporation of nano Hydroxyapatite- tyrosine amino acid at different concentrations in the zinc oxide eugenol sealer formula in terms of bioactivity analysis. Methods: The nano hydroxy apatite-tyrosine amino acid was incorporated into the original zinc oxide eugenol (endosell) at different concentrations starting from (10 – 20)%. The chemical changes in zinc oxide eugenol before and after addition were characterized using FTIR and XRD. The setting time test was done according to ADA specification no. 57. The bioactivity analysis for the zinc oxide eugenol before and after the addition was evaluated according to ISO/FDIS 23317:2007(E) by using 28 days of storage in phosphate buffer saline, and then the hydroxyapatite precipitation and Ca/P ratio was evaluated using FESEM/EDX. Results: The FTIR and XRD confirmed the setting reaction occurrence among the (original ZOE, nHAP, and Tyr). The XRD and FESEM/EDX analyses confirmed the HAP precipitation on the ZOE sample surfaces after the addition of (nHAP-Tyr a.a) and this precipitation was increased with increased concentrations of additions. Conclusion: Incorporated (20) % of equal amounts of “nHA-Tyr a.a” can convert the ZOE to bioactive sealer as confirmed by XRD and FESEM/EDX. However, other characteristic analyses like Nuclear magnetic resonance, atomic force microscopy, and in vivo animal study were needed to further confirm the results.
Comparing disinfection efficiency of ozone and peroxone in water containing Giardia duodenalis cysts
Authors: Reis Gabriela dos , Nakada Liane Yuri Kondo , Leonel Lays Paulino , Guimarães José Roberto
Published: November 2024

This study aimed to investigate the efficiency of ozone and peroxone for the disinfection of water containing Giardia duodenalis cysts. Dechlorinated tap water (TW) and spring water (SW) samples were inoculated with a purified commercial suspension containing 105 cysts of Giardia duodenalis. The membrane filtration method was employed for cyst concentration, with average recovery efficiencies of 43.3% in TW and 73.3% in SW. Visualization of the cysts was carried out by Immunofluorescence Assay (IFA). The use of ozone as a disinfectant in SW showed a concentration-dependent increase in cyst damage, reaching 98% non-viability at the highest ozone concentration (5 mg L-1). The addition of hydrogen peroxide (H2O2) improved the process, as 2.5 mg L-1 of ozone at an H2O2 / O3 ratio of 0.3 caused morphological damage to 99% of the cysts. The data indicated that the lower H2O2 / O3 ratio resulted in better overall performance in terms of cyst damage. In TW, the oxidation behavior differed, with no clear difference observed between the lowest and highest ozone concentrations causing cyst wall damage. The presence of alkalinity in TW negatively affected the disinfection process, likely due to the scavenger effect of alkalinity compounds on hydroxyl radicals. The use of peroxone process with an H2O2 / O3 ratio of 0.5 yielded the highest damage to cysts in TW. The findings contribute to the understanding of factors influencing the efficacy of oxidation techniques and provide insights for developing effective disinfection strategies for water treatment systems.
HBIM e SIG para gestão da paisagem cultural da Pampulha
Authors: Dionizio Rafael Fernandes , Dezen-Kempter Eloisa
Published: November 2024

Os desafios da documentação e da gestão do património arquitetônico a várias escalas, incluindo as paisagens culturais, são complexos devido às características únicas dos edifícios históricos, dos seus sistemas de construção e do seu valor cultural. A gestão de um conjunto patrimonial torna-se ainda mais exigente dada a sua abrangência. Para ultrapassar estes desafios, surgiram novas tecnologias, como a fotogrametria, a digitalização 3D, a modelação semântica e a integração da Modelagem da Informação das Construção (BIM) e Sistemas de informações Geográficas (SIG). A aplicação do BIM e do SIG na gestão do património permite uma compreensão abrangente das características arquitetônicas e funcionais dos edifícios históricos. A integração do BIM e do SIG envolve a extração e a transformação de informações geométricas e semânticas; no entanto, a perda de dados durante as transferências de software e a necessidade de estruturar as informações através de normas representam desafios para garantir uma integração eficaz. Este artigo aborda a integração da Modelagem Informação da Construção Histórica (HBIM) e do SIG na gestão da paisagem cultural do Complexo da Pampulha de Oscar Niemeyer, incluindo a área de proteção cultural do entorno da Lagoa da Pampulha. O estudo se concentra nas obras arquitetônicas únicas de Niemeyer para avaliar a eficácia do software de integração e os benefícios do modelo HBIM-SIG na gestão do patrimônio, estabelecendo um fluxo de trabalho para a preservação e manutenção desses bens culturais usando essas tecnologias. Esta abordagem pode fornecer uma base sólida para a conservação do património arquitetônico, permitindo uma análise detalhada, uma tomada de decisão eficiente e uma melhor compreensão das características históricas e culturais da área de proteção da Pampulha. Os resultados alcançados demonstram a importância de garantir a interoperabilidade entre os sistemas BIM e GIS para alcançar uma gestão bem sucedida e integrada deste património arquitetônico distinto.
Crescimento dos trabalhadores por aplicativo nos transportes no Brasil
Authors: Neto João Hallak , Simões André , Dick Paulo , Roubaud François , Razafindrakoto Mireille
Published: November 2024

Desde meados da década de 2010, o mercado de trabalho brasileiro enfrentou crises marcadas por aumento da informalidade e da desocupação. A pandemia de Covid-19 exacerbou a situação, resultando na perda de mais de 10 milhões de empregos em 2020, com uma recuperação lenta subsequentemente. Em contraste, os empregos de plataforma, que emergiram a partir de 2016, mostraram crescimento significativo. No entanto, quantificar e qualificar esses empregos é desafiador devido à falta de ferramentas adequadas de mensuração. Este artigo procura contribuir para o debate sobre conceitos e ferramentas estatísticas para medir essas ocupações no Brasil e fornecer um panorama dos empregos em plataformas, focando especificamente em motoristas e entregadores – grupo profissional que registrou expressivo crescimento nos últimos anos. A análise utiliza a Pesquisa Nacional por Amostra de Domicílios Contínua do IBGE para comparar os períodos pré e pós-surgimento das plataformas.