bluuebunny/crossref_metadata_2025 huggingface dataset:
REPRESENTASI NILAI MOTIVASI PADA BUKU "I HATE DIET" KARYA YULIA BALTSCHUN
Authors: Nur Abidah Amelia , Firmonasari Aprillia
Published: August 2022

Verbal language is vital in communication and is the most important means of interaction. By the significant role of verbal language, visuals are often less considered unnecessary, even though they could help to understand communication better. Verbal and visual language are interconnected and simultaneously build a strong, complete, structured text. This research focused on how a book writer communicates using two or more modes simultaneously, namely text and images, which is called multimodal discourse analysis, particularly social semiotics. This study analyzes the illustrated book "I Hate Diet" by Yulia Baltschun. Using a descriptive qualitative method that refers to the theory of reading images, Kress & Leeuwen's (2006) analysis relates to the existence of representational and interactive meanings with images divided into three aspects: information value, salience, and framing. In connection with the data analysis in the form of text or verbal, it is analyzed using the theory of seven development tasks by Gee (2011). The results indicated the meanings of the image or visual illustrations supported by verbal or text analysis. There are several representations of meaning in it, namely the meaning of motivational invitations and warnings or meanings that remind.
Beyond black and white: an inclusive reciprocal mentoring model to promote diversity, engagement and understanding
Authors: Sarsah Harry , Abraham Michielle , Leech Darren
Published: August 2022

The NHS is the largest employer of Black, Asian and minority ethnic staff in the UK. However, 15% of staff from these ethnic backgrounds have reported experiencing discrimination at work. Reverse mentoring programmes have been trialled as way of raising awareness and understanding of issues relating to equality, diversity and inclusion, particularly among senior management. However, these programmes have drawn some criticism. Instead, a programme based on reciprocal mentoring could be a more effective means of creating a more inclusive NHS culture. This article explores how such an approach could work in practice, with discussion of a pilot reciprocal mentoring programme that was implemented at Chelsea and Westminster Hospitals NHS Foundation Trust from September 2020 to May 2021.
Experimental Observations of Thermal Fluctuations of Metamaterial Optical Properties
Authors: Papas Dimitrios , Li Jinxiang , Liu Tongjun , Ou Jun-Yu , MacDonald Kevin F. , Plum Eric , Zheludev Nikolay I.
Published: August 2022

We demonstrate that fluctuations in the optical properties of nanomechanical photonic metamaterials can reach 1% at room temperature. Such fluctuations arise from ‘Brownian’ motion and peak at the frequencies of the nanostructures’ natural mechanical modes.
Macroscopic condensation of photon noise in nonlinear dissipative systems
Authors: Rivera Nicholas , Sloan Jamison , Salamin Yannick , Soljačić Marin
Published: August 2022

We present a new type of dissipation unique to nonlinear optical systems. We show how this phenomenon enables a new type of laser that deterministically creates macroscopic Fock states of light at optical frequencies.
Demonstration of Single-Photon Synapses
Authors: Khan Saeed , Primavera Bryce A. , McCaughan Adam N. , Buckley Sonia M. , Chiles Jeff , Tait Alexander N. , Mirin Richard P. , Nam Sae Woo , Shainline Jeffrey M.
Published: August 2022

We present a single-photon-sensitive synapse realized by the monolithic integration of superconducting-nanowire single-photon detectors with Josephson electronics. Data show the utility of the synapse for achieving synaptic weighting and integration of pulse trains.
Geometric Parameter Extraction-based Receiver IQ imbalance correction for MQAM systems
Authors: Mir Sameer Ahmad , Venkatasubramani Lakshmi Narayanan , Koilpillai R. David , Venkitesh Deepa
Published: August 2022

We present a modulation transparent geometric parameter extraction method to compensate for the receiver IQ imbalance. We evaluate the algorithm’s performance for various imbalance values for 32-GBd 16/64QAM signals in both simulations and through experiments.
28.224-Tbit/s Capacity over 8191.898-km in Full C-band Using Single-mode Fibers with Adaptive Chromatic Dispersion and Nonlinearity Compensation
Authors: Jiang Lin , Yi Anlin , Yan Lianshan , Pu Zhengyu , Yu Youren , He Xingchen , Pan Wei , Luo Bin
Published: August 2022

Transmission capacity of 28.224-Tbit/s over 8191.898-km single-mode fibers based on probabilistically-shaped 16QAM has been experimentally demonstrated. The BER results after adaptive chromatic dispersion and nonlinearity compensation are lower than 25%FEC threshold for all C-band channels.
Autoencoder-Optimized Geometric Constellation Shaping for Unamplified Coherent Optical Links
Authors: Oliveira B. M. , Neves M. S. , Guiomar F. P. , Medeiros M. C. R. , Monteiro P. P.
Published: August 2022

Using end-to-end deep learning, we experimentally demonstrate the optimized design of geometric constellation shaping for coherent unamplified links. A power budget gain of more than 2 dB is demonstrated for 8-ary constellations.
PCformer: an MVI recognition method via classification of the MVI boundary according to histopathological images of liver cancer
Authors: Sun Lin , Sun Zhanquan , Wang Chaoli , Cheng Shuqun , Wang Kang , Huang Min
Published: August 2022

Liver cancer is one of the most common cancers leading to death in the world. Microvascular invasion (MVI) is a principal reason for the poor long-term survival rate after liver cancer surgery. Early detection and treatment are very important for improving the survival rate. Manual examination of MVI based on histopathological images is very inefficient and time consuming. MVI automatic diagnosis based on deep learning methods can effectively deal with this problem, reduce examination time, and improve detection efficiency. In recent years, deep learning-based methods have been widely used in histopathological image analysis because of their impressive performance. However, it is very challenging to identify MVI directly using deep learning methods, especially under the interference of hepatocellular carcinoma (HCC) because there is no obvious difference in the histopathological level between HCC and MVI. To cope with this problem, we adopt a method of classifying the MVI boundary to avoid interference from HCC. Nonetheless, due to the specificity of the histopathological tissue structure with the MVI boundary, the effect of transfer learning using the existing models is not obvious. Therefore, in this paper, according to the features of the MVI boundary histopathological tissue structure, we propose a new classification model, i.e., the PCformer, which combines the convolutional neural network (CNN) method with a visual transformer and improves the recognition performance of the MVI boundary histopathological image. Experimental results show that our method has better performance than other models based on a CNN or a transformer.
Telecom-wavelength spectra of a Rydberg state in a hot vapor
Authors: Li Wenfang , Du Jinjin , Lam Mark , Li Wenhui
Published: August 2022

We study telecom-wavelength spectra of a Rydberg state in an atomic vapor with a three-photon excitation scheme. Two lasers of 780 nm and 776 nm are used to pump rubidium-85 atoms in a vapor cell to the 5D5/2 state, from which a probe beam of 1292 nm in the O-band telecommunication wavelength drives a transition to the 21F7/2 Rydberg state. We investigate the probe spectra over the power of pump lasers. The simulation based on a 4-level theoretical model captures the main features of the experimental results. This spectroscopic study paves the way for future experiments of making a direct link between fiber optics and radio transmission via Rydberg atoms.
Color dynamic holographic display based on complex amplitude modulation with bandwidth constraint strategy
Authors: Pi Dapu , Wang Jie , Liu Juan , Li Jingnan , Sun Yutong , Yang Yan , Zhao Weirui , Wang Yongtian
Published: August 2022

In this Letter, we introduce a multiplexing encoding method with a bandwidth constraint strategy to realize a color dynamic holographic display based on complex amplitude modulation (CAM). The method first uses the angular spectrum method (ASM) with a bandwidth constraint strategy to calculate the diffracted wavefronts of red, green, and blue channels. Then the diffracted wavefronts of three channels are synthesized into a color-multiplexed hologram (CMH) based on the double-phase method after they interfere with off-axis reference lights. The color 3D objects can be reconstructed when the combination of red, green, and blue lights is used to illuminate the double-phase CMH, and a 4f system with a slit filter is introduced to extract the desired spectrums. Numerical simulations and optical experiments are performed to verify the effectiveness of the proposed method and the results show that it can achieve a color holographic display with high quality. Our proposal is simple and fast, and the display system is compact. It is expected that our proposed method could in future be widely used in the holographic field.
Design and fabrication of As2S3-based non-quarterwave multi-cavity Fabry–Perot filters with the laser-adjustable central wavelength
Authors: Bourgade Antoine , Lemarquis Frédéric , Moreau Antonin , Begou Thomas , Lumeau Julien
Published: August 2022

We present a thorough study of the use of As2S3
thin films for the fabrication of high-performance multi-cavity
bandpass filters. We show that such layers can be used inside a
non-quarterwave multi-cavity Fabry–Perot structure to produce local
changes of the central wavelength of the filter using photosensitive
properties of this material. In particular, we study the impact of
these index changes on the spectral performances of the filters and
show how to adapt the design of the Fabry–Perot structures to produce
a spectral shift without degrading the bandpass profile. Double- and
three-cavity Fabry–Perot filters are theoretically and experimentally
studied.
Spatiotemporal dynamics of human high gamma discriminate naturalistic behavioral states
Authors: Alasfour Abdulwahab , Gabriel Paolo , Jiang Xi , Shamie Isaac , Melloni Lucia , Thesen Thomas , Dugan Patricia , Friedman Daniel , Doyle Werner , Devinsky Orin , Gonda David , Sattar Shifteh , Wang Sonya , Halgren Eric , Gilja Vikash
Published: August 2022

In analyzing the neural correlates of naturalistic and unstructured behaviors, features of neural activity that are ignored in a trial-based experimental paradigm can be more fully studied and investigated. Here, we analyze neural activity from two patients using electrocorticography (ECoG) and stereo-electroencephalography (sEEG) recordings, and reveal that multiple neural signal characteristics exist that discriminate between unstructured and naturalistic behavioral states such as “engaging in dialogue” and “using electronics”. Using the high gamma amplitude as an estimate of neuronal firing rate, we demonstrate that behavioral states in a naturalistic setting are discriminable based on long-term mean shifts, variance shifts, and differences in the specific neural activity’s covariance structure. Both the rapid and slow changes in high gamma band activity separate unstructured behavioral states. We also use Gaussian process factor analysis (GPFA) to show the existence of salient spatiotemporal features with variable smoothness in time. Further, we demonstrate that both temporally smooth and stochastic spatiotemporal activity can be used to differentiate unstructured behavioral states. This is the first attempt to elucidate how different neural signal features contain information about behavioral states collected outside the conventional experimental paradigm.
Predictability and stability testing to assess clinical decision instrument performance for children after blunt torso trauma
Authors: Kornblith Aaron E. , Singh Chandan , Devlin Gabriel , Addo Newton , Streck Christian J. , Holmes James F. , Kuppermann Nathan , Grupp-Phelan Jacqueline , Fineman Jeffrey , Butte Atul J. , Yu Bin
Published: August 2022

Objective

The Pediatric Emergency Care Applied Research Network (PECARN) has developed a clinical-decision instrument (CDI) to identify children at very low risk of intra-abdominal injury. However, the CDI has not been externally validated. We sought to vet the PECARN CDI with the Predictability Computability Stability (PCS) data science framework, potentially increasing its chance of a successful external validation.

Materials & methods

We performed a secondary analysis of two prospectively collected datasets: PECARN (12,044 children from 20 emergency departments) and an independent external validation dataset from the Pediatric Surgical Research Collaborative (PedSRC; 2,188 children from 14 emergency departments). We used PCS to reanalyze the original PECARN CDI along with new interpretable PCS CDIs developed using the PECARN dataset. External validation was then measured on the PedSRC dataset.

Results

Three predictor variables (abdominal wall trauma, Glasgow Coma Scale Score <14, and abdominal tenderness) were found to be stable. A CDI using only these three variables would achieve lower sensitivity than the original PECARN CDI with seven variables on internal PECARN validation but achieve the same performance on external PedSRC validation (sensitivity 96.8% and specificity 44%). Using only these variables, we developed a PCS CDI which had a lower sensitivity than the original PECARN CDI on internal PECARN validation but performed the same on external PedSRC validation (sensitivity 96.8% and specificity 44%).

Conclusion

The PCS data science framework vetted the PECARN CDI and its constituent predictor variables prior to external validation. We found that the 3 stable predictor variables represented all of the PECARN CDI’s predictive performance on independent external validation. The PCS framework offers a less resource-intensive method than prospective validation to vet CDIs before external validation. We also found that the PECARN CDI will generalize well to new populations and should be prospectively externally validated. The PCS framework offers a potential strategy to increase the chance of a successful (costly) prospective validation.
Prevalence and factors associated with delayed antiretroviral therapy initiation among adults with HIV in Alebtong district, Northern Uganda: A facility-based study
Authors: Ochen Anthony Mark , Lubogo David , Ediau Michael , Nankabirwa Victoria
Published: August 2022

Globally, an estimated 36.7 million people were living with HIV (PLWH) and of these, 2.1 million were newly infected and 1.1 million died of AIDS in 2015. By 2016, only 67% of adults eligible for ART were enrolled in ART in Uganda. Delayed ART initiation has been shown to contribute to the continued transmission of HIV as well as to higher morbidity and mortality among persons living with HIV. Our study examined the prevalence and factors associated with delayed ART initiation among adults with HIV in Alebtong district, Northern Uganda. A cross-sectional study involving 432 adults living with HIV was conducted between March and June 2018 in Alebtong district. Quantitative data were collected using interviewer-administered questionnaires and desk reviews using a data extraction tool. A binary logistic regression using a hierarchical modelling technique was used at the multivariable level to determine associations at a 95% confidence interval and p<0.05 using SPSS Statistics software version 23.0. Overall, 432 participants were enrolled in the study, of whom 18.1% (78/432) had delayed ART initiation. After final adjustment, our key findings showed a significantly lower odds of delayed ART initiation among older respondents (aOR = 0.35, 95% CI: 0.16–0.76); adherence to HIV clinic appointments, (aOR = 0.06, 95% CI: 0.02–0.15); and linkage to the HIV clinic the same day HIV test was conducted (aOR = 0.21, 95% CI: 0.08–0.55). However, a significantly higher odds of delayed ART initiation was observed among those whose cultures do not support the use of ART (aOR = 10.62, 95% CI: 3.04–32.08). Reducing delayed ART initiation in the district requires strengthening the involvement of adolescents and young people in the HIVAIDS programming, scaling up the implementation of the same-day ART initiation policy, and addressing negative cultural beliefs affecting early ART initiation in the district.
Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects
Authors: Callahan Michael , Treston Anthony M. , Lin Grace , Smith Marla , Kaufman Brian , Khaliq Mansoora , Evans DeWald Lisa , Spurgers Kevin , Warfield Kelly L. , Lowe Preeya , Duchars Matthew , Sampath Aruna , Ramstedt Urban
Published: August 2022

Background

UV-4 (N-(9’-methoxynonyl)-1-deoxynojirimycin, also called MON-DNJ) is an iminosugar small-molecule oral drug candidate with in vitro antiviral activity against diverse viruses including dengue, influenza, and filoviruses and demonstrated in vivo efficacy against both dengue and influenza viruses. The antiviral mechanism of action of UV-4 is through inhibition of the host endoplasmic reticulum-resident α-glucosidase 1 and α-glucosidase 2 enzymes. This inhibition prevents proper glycan processing and folding of virus glycoproteins, thereby impacting virus assembly, secretion, and the fitness of nascent virions.

Methodology/Principal findings

Here we report a first-in-human, single ascending dose Phase 1a study to evaluate the safety, tolerability, and pharmacokinetics of UV-4 hydrochloride (UV-4B) in healthy subjects (ClinicalTrials.gov Identifier NCT02061358). Sixty-four subjects received single oral doses of UV-4 as the hydrochloride salt equivalent to 3, 10, 30, 90, 180, 360, 720, or 1000 mg of UV-4 (6 subjects per cohort), or placebo (2 subjects per cohort). Single doses of UV-4 hydrochloride were well tolerated with no serious adverse events or dose-dependent increases in adverse events observed. Clinical laboratory results, vital signs, and physical examination data did not reveal any safety signals. Dose-limiting toxicity was not observed; the maximum tolerated dose of UV-4 hydrochloride in humans has not yet been determined (>1000 mg). UV-4 was rapidly absorbed and distributed after dosing with the oral solution formulation used in this study. Median time to reach maximum plasma concentration ranged from 0.5–1 hour and appeared to be independent of dose. Exposure increased approximately in proportion with dose over the 333-fold dose range. UV-4 was quantifiable in pooled urine over the entire collection interval for all doses.

Conclusions/Significance

UV-4 is a host-targeted broad-spectrum antiviral drug candidate. At doses in humans up to 1000 mg there were no serious adverse events reported and no subjects were withdrawn from the study due to treatment-emergent adverse events. These data suggest that therapeutically relevant drug levels of UV-4 can be safely administered to humans and support further clinical development of UV-4 hydrochloride or other candidate antivirals in the iminosugar class.

Trial registration

ClinicalTrials.gov NCT02061358 https://clinicaltrials.gov/ct2/show/NCT02061358.
Toxoplasmosis in patients with an autoimmune disease and immunosuppressive agents: A multicenter study and literature review
Authors: Durieux Marie-Fleur , Lopez Jean-Guillaume , Banjari Maher , Passebosc-Faure Karine , Brenier-Pinchart Marie-Pierre , Paris Luc , Gargala Gilles , Berthier Sabine , Bonhomme Julie , Chemla Cathy , Villena Isabelle , Flori Pierre , Fréalle Emilie , L’Ollivier Coralie , Lussac-Sorton Florian , Montoya José Gilberto , Cateau Estelle , Pomares Christelle , Simon Loïc , Quinio Dorothée , Robert-Gangneux Florence , Yera Hélène , Labriffe Marc , Fauchais Anne-Laure , Dardé Marie-Laure
Published: August 2022

Background

Cases of Toxoplasma reactivation or more severe primary infection have been reported in patients receiving immunosuppressive (IS) treatment for autoimmune diseases (AID). The purpose of this study was to describe features of toxoplasmosis occurring in patients with AID treated by IS therapy, excluded HIV-positive and transplant patients.

Methods

A multicenter descriptive study was conducted using data from the French National Reference Center for Toxoplasmosis (NRCT) that received DNA extracts or strains isolated from patients, associated with clinical data. Other cases were retrieved through a questionnaire sent to all French parasitology and internal medicine departments. Furthermore, a systematic literature review was conducted.

Results

61 cases were collected: 25 retrieved by the NRCT and by a call for observations and 36 from a literature review. Half of the cases were attributed to reactivation (50.9%), and most of cases (49.2%) were cerebral toxoplasmosis. The most common associated AID were rheumatoid arthritis (28%) and most frequent treatments were antimetabolites (44.3%). Corticosteroids were involved in 60.7% of cases. Patients had a favorable outcome (50.8%) but nine did not survive. For 12 cases, a successful Toxoplasma strain characterization suggested the possible role of this parasitic factor in ocular cases.

Conclusion

Although this remains a rare condition, clinicians should be aware for the management of patients and for the choice of IS treatment.
Quantitative reverse transcription PCR assay to detect a genetic marker of pyrethroid resistance in Culex mosquitoes
Authors: Hager Kelli M. , Gaona Erick , Kistler Amy , Ratnasiri Kalani , Retallack Hanna , Barretto Miguel , Wheeler Sarah S. , Hoover Christopher M. , Haas-Stapleton Eric J.
Published: August 2022

Pyrethroid insecticides are widely used to control mosquitoes that transmit pathogens such as West Nile virus (WNV) to people. Single nucleotide polymorphisms (SNP) in the knockdown resistance locus (kdr) of the voltage gated sodium channel (Vgsc) gene in Culex mosquitoes are associated with knockdown resistance to pyrethroids. RNAseq was used to sequence the coding region of Vgsc for Culex tarsalis Coquillett and Culex erythrothorax Dyar, two WNV vectors. The cDNA sequences were used to develop a quantitative reverse transcriptase PCR assay that detects the L1014F kdr mutation in the Vgsc. Because this locus is conserved, the assay was used successfully in six Culex spp. The resulting Culex RTkdr assay was validated using quantitative PCR and sequencing of PCR products. The accuracy of the Culex RTkdr assay was 99%. The L1014F kdr mutation associated with pyrethroid resistance was more common among Cx. pipiens than other Culex spp. and was more prevalent in mosquitoes collected near farmland. The Culex RTkdr assay takes advantage of the RNA that vector control agencies routinely isolate to assess arbovirus prevalence in mosquitoes. We anticipate that public health and vector control agencies may employ the Culex RTkdr assay to define the geographic distribution of the L1014F kdr mutation in Culex species and improve the monitoring of insecticide resistance that will ultimately contribute to effective control of Culex mosquitoes.
Locally weighted PCA regression to recover missing markers in human motion data
Authors: Kieu Hai Dang , Yu Hongchuan , Li Zhuorong , Zhang Jian Jun
Published: August 2022

“Missing markers problem”, that is, missing markers during a motion capture session, has been raised for many years in Motion Capture field. We propose the locally weighted principal component analysis (PCA) regression method to deal with this challenge. The main merit is to introduce the sparsity of observation datasets through the multivariate tapering approach into traditional least square methods and develop it into a new kind of least square methods with the sparsity constraints. To the best of our knowledge, it is the first least square method with the sparsity constraints. Our experiments show that the proposed regression method can reach high estimation accuracy and has a good numerical stability.
A realist evaluation to identify targets to improve the organization of compression therapy for deep venous thrombosis- and chronic venous disease patients
Authors: Schreurs Rachel H. P. , Joore Manuela A. , De Bruijn-Geraets Daisy P. , ten Cate Hugo , ten Cate-Hoek Arina J.
Published: August 2022

Background

Although compression therapy is well established for patients with deep venous thrombosis (DVT) and chronic venous disease (CVD), considerable variation exists in its organization in clinical practice which may impact patient outcomes. The current study aims to deepen our understanding of the main drivers of the complex care organization for compression therapy and to identify targets for improvement.

Methods

This realist evaluation includes a mixed-method design consisting of semi-structured interviews with patients and health care professionals involved in compression therapy (n = 30), stakeholder meetings (n = 2) and surveys (n = 114). Data were collected to create the content of context-mechanism-outcome-configurations (CMOcs) important in compression therapy. Based on these CMOcs, targets for improvement to optimize the organization of compression care were identified.

Results

We identified overarching context factors and mechanisms targeting four optimal outcomes for the organization of compression therapy: selecting initial compression therapy types that support patient’s self-reliance (1), evidence based selection of elastic compression stocking type and class (2), patient-based selection of assistive devices (3), individualizing treatment duration for DVT patients (4a) and providing follow-up for CVD patients (4b). We found that increasing health care professionals’ knowledge of compression therapy, the availability of unambiguous protocols and guidelines, increasing patient involvement (and if applicable their informal care giver) in the decision making process, the accessible availability of resources, and increasing interdisciplinary consultation enhanced desirable outcomes. These targets triggered mechanisms such as increased health care professionals’ willingness, confidence and motivation to provide patient-based care and increased patients’ self-confidence and self-efficacy.

Conclusions

This study provides a detailed insight into what needs to be in place to optimize compression care and identified five main targets for improvement.
Social relationships and their associations with affective symptoms of women with breast cancer: A scoping review
Authors: Yang Yesol , Lin Yufen , Sikapokoo Grace Oforiwa , Min Se Hee , Caviness-Ashe Nicole , Zhang Jing , Ledbetter Leila , Nolan Timiya S.
Published: August 2022

Background

Problems in affective and cognitive functioning are among the most common concurrent symptoms that breast cancer patients report. Social relationships may provide some explanations of the clinical variability in affective-cognitive symptoms. Evidence suggests that social relationships (functional and structural aspects) can be associated with patients’ affective-cognitive symptoms; however, such an association has not been well studied in the context of breast cancer.

Purpose

The purpose of this scoping review was to address the following question: What social relationships are associated with affective-cognitive symptoms of women with breast cancer?

Methods

This scoping review used the framework proposed by Arksey and O’Malley and PRISMA-Sc. Studies published by February 2022 were searched using four databases: MEDLINE (PubMed), Embase (Elsevier), PsycINFO (EBSCOhost), and Web of Science (Clarivate). All retrieved citations were independently screened and eligibility for inclusion was determined by study team members. Extracted data included research aims, design, sample, type and measures of social relationships (functional and structural), and the association between social relationships and affective-cognitive symptoms

Results

A total of 70 studies were included. Affective symptoms were positively associated with social support, family functioning, quality of relationships, social networks, and social integration, whereas the negative association was found with social constraints.

Conclusion

Our findings suggest positive social relationships may mitigate affective symptoms of women with breast cancer. Thus, health care providers need to educate patients about the importance of building solid social relationships and encourage them to participate in a supportive network of friends and family members.
Hardcore punk as an effort to Indigenize the underground scene in La Paz during the neo-liberal era of resistance 1993–2003
Authors: Tapia Reynaldo , Mendoza Boris
Published: August 2022

In Bolivia, neo-liberalism did not only have social-economic and political effects, but it also created spaces that allowed for new discourses related to culture and national identity. This research focuses on the changes of the metal underground scene in La Paz that led to the formation of a hardcore punk scene that tried to incorporate Indigenous symbolism in their music and performances as a form of resistance against western-cultural hegemony but also to highlight the positive values of their ancestral cultural heritage. Scholars, journalists and activists have written extensively about the transformations in Bolivia during the age of neo-liberalism but there has not been much research that focused on youth movements specifically those that use music to inspire new forms of social dialogues concerning national identity. This research is self-ethnographic and it includes qualitative in-depth interviews of band members and media figures of that time. The La Paz hardcore punk scene grew as an effort from band members to Indigenize the metal underground scene based on their interpretation of what they believed was Indigenous since none of the band members themselves were considered Indigenous. The meaning of Indigenous symbolism in their music was a result of their daily experiences of the social-political contentious environment during the country’s neo-liberal era. Street protesters used Indigenous symbols to defy the western-led free-market economic policies of the Washington Consensus. Therefore, the need to distinguish themselves from a metal musical genre that was traditionally western gave rise to a hardcore punk scene that focused on Indigenous cultural pride intricately connected to a form of patriotism and national pride. This was fuelled by the emergence of a national collective consciousness to reclaim the Indigenous culture due to the failures of western economic policies and US interventions tied to the ‘War on Drugs’.
Jogos, brincadeiras, gamificação e cultura maker no processo de educação e aprendizagem
Authors: Medeiros Maria Aparecida de Souza
Published: August 2022

The current world is constantly undergoing technological innovations and it is quite common to use them as tools in learning due to the countless benefits associated with different areas of human development. The purpose of this article is to carry out a literature review presenting an overview and concepts about games, games, gamification and maker culture in the education and learning process. In this research, it was possible to perceive the important role of educators in the teaching and learning process and in the transmission of knowledge through the adoption of didactic strategies that go beyond the traditional methods of the past. One of the pedagogical practices that favor student engagement is the use of games and games that arouse interest and facilitate the learning and cognitive development and skills of children and even young people and adults in a multidisciplinary way. Gamification and the maker movement emerge to expand and contribute to this educational development where the student learns to learn by doing in a more meaningful and structured way.
Monkeypox: World health emergency in 2022
Authors: Menezes Filho Antonio Carlos Pereira de , Ventura Matheus Vinicius Abadia , Alves Ivan , Taques Aparecida Sofia
Published: August 2022

Monkeypox appeared in 1970 in Central Africa and since then the national and international health agencies have not given the proper response to this viral infection that hit small African populations until then. Today in 2022 it becomes an international emergency disease according to the World Health Organization. Monkeypox has been isolated and identified in more than 75 countries since the publication of this Emergency Technical Note. So far diagnosed cases exceed 15,000 cases worldwide. In Brazil, the main states with the highest identification activity for this Orthopoxvirus are Rio de Janeiro, Minas Gerais, Distrito Federal, Paraná and Goiás States. However, this disease that causes pustules all over the body, fever, malaise, body aches and has a high rate of transmissibility through sexual contact, especially by homosexuals, has become a major health problem internationally. Possibly we are talking about a new pandemic like the one we saw for Smallpox, Tuberculosis, Black Death, Covid-19 and Spanish Flu.
Avaliação físico-química da farinha de pupunha (Bactris gasipaes Kunth) para uso alimentício
Authors: Souza Patrick Gomes de , Pantoja Lilian , Santos Alexandre Soares dos , Marinho Helyde Albuquerque , Silva João Batista Almeida e
Published: August 2022

O objetivo geral deste trabalho foi avaliar as características físico-químicas da farinha de pupunha adquirida em uma feira da cidade de Manaus/AM. Os cachos de pupunha foram adquiridos na Feira da Banana, na cidade de Manaus/AM, e levados para o Laboratório de Alimentos e Nutrição (LAN), do Instituto Nacional de Pesquisas da Amazônia (INPA). Os frutos foram selecionados quanto a injúrias e maturação. Os frutos selecionados seguiram para a despolpa, desidratação, secagem, trituração e acondicionamento. A farinha de pupunha foi submetida a análises físico-químicas de umidade, lipídios, fibra total, cinzas, proteínas, carboidratos, valor energético, pH, sólidos solúveis totais, acidez, açúcares, amido, além de compostos fenólicos e flavonoides. A farinha de pupunha possui baixo teor de umidade, com 2,83 %, teor de lipídeos de 12,72% , proteínas de 4,89 %, carboidratos de 71,78 %, além de excelentes resultados para compostos fenólicos, com 88,74 mg/100g e flavonoides com 14,52 mg/100g. A farinha de pupunha apresentou excelente qualidade físico-química evidenciando que pode ser uma excelente alternativa para se tornar um produto com alta viabilidade para o mercado.
Phytochemistry and biological activities of the floral hydroethanolic extract of Ipomoea carnea Jacq. (Convolvulaceae)
Authors: Menezes Filho Antonio Carlos Pereira de , Ventura Matheus Vinicius Abadia , Castro Carlos Frederico de Souza , Taques Aparecida Sofia , Alves Ivan
Published: August 2022

Ipomoea carnea is a species found in Brazil, and is considered toxic to animals. The study aimed to assess the phytochemical composition and biological activities of the floral extract of I. carnea. Flowers were collected and the hydroethanolic extract produced. Phytochemistry was evaluated for numerous groups of secondary metabolisms, biological activities were performed to reduce the free radical DPPH, toxicity on Artemia salina and photoprotective action. Phytochemical prospecting demonstrated the presence of several classes of phytocomposites of great importance for industries, antioxidant activity with IC50 = 13.26 µL mL-1, lethality concentration on A. salina with LC50 = 455.31µg mL-1 and ultraviolet protection factor UVA, UVB and UVC. The hydroethanolic floral extract showed potential with several phytochemical classes and biological activities.
Avaliação de diferentes solventes para extração de compostos fenólicos totais em farinha de Byrsonima coccolobifolia Kunth.
Authors: Menezes Filho Antonio Carlos Pereira de , Ventura Matheus Vinicius Abadia , Batista-Ventura Hellen Regina Fernandes , Castro Carlos Frederico de Souza , Teixeira Marconi Batista , Soares Frederico Antônio Loureiro
Published: August 2022

O presente trabalho teve por objetivo avaliar diferentes solventes visando à extração de compostos fenólicos totais das farinhas do fruto de murici-bravo. Farinhas da casca, polpa e pirênio com sementes foram produzidas. Os solventes extratores foram: água, etanol 100, 80 e 70% e metanol 100, 80 e 70%. Para a determinação dos quantitativos de fenólicos totais, foi utilizado reagente de Folin-Ciocalteau. Os teores de fenólicos totais para farinha da casca foram 19,19 mg EAG 100 g-1 para solução etanol 70%, seguido de 18,91 solução de etanol 80% e 18,72 mg EAG 100 g-1 para metanol 100%; os extratos farináceos da polpa apresentou melhores rendimentos em etanol 100% 19,08 e água 19,04 mg EAG 100 g-1 seguidos pelas soluções de etanol 80% e metanol 70% iguais a 18,80 e 18,70 mg EAG 100 g-1, e para os extratos farináceos do pirênio e sementes com 17,54 para solução metanólica 80% e 17,10 mg EAG 100 g-1 para água, seguidas de 16,70 para solução etanólica 70% e de 16,56 mg EAG 100 g-1 para metanol 100%. Os solventes aplicados neste estudo apresentaram resultados satisfatórios na extração dos compostos fenólicos. Contudo, o uso de solventes menos agressivos como a água e o etanol apresentou ser excelentes opções de uso, visto que, o metanol apresenta toxicidade no ambiente.
Contribuições do PIBID para a formação inicial de professores de Física: aplicação da oficina projetor de celular
Authors: Silva José Jefferson da , Medeiros Geneci Cavalcanti Moura de , Souza Alcindo Mariano de
Published: August 2022

O objetivo deste trabalho refere-se a um relato das atividades desenvolvidas pelos bolsistas, junto ao Programa de Iniciação à Docência (PIBID), do curso de Licenciatura em Física do Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Norte – IFRN/Campus João Câmara. O trabalho se caracteriza como um relato de atividades, vivenciada por um grupo de licenciandos - bolsistas PIBID - buscando discutir as potencialidades do PIBID para a formação inicial de professores de Física. O desenvolvimento das atividades do PIBID partiu de um conhecimento do contexto escolar, seguido por observação de aulas de Física e, finalmente, intervenção em sala de aula, trazendo estratégias de ensino de maneiras diversificadas. Mostrando em sua fundamentação a importância do PIBID dentro do âmbito escolar, pois está convivendo com toda comunidade escolar, nos torna verdadeiros educadores dentro do ensino de Física.
Avaliação físico-química e sensorial da cerveja artesanal estilo Wood e Barrel Aged adicionada de chip de jatobá (Hymenaea courbaril L.)
Authors: Silva Hiran Gonçalves da , Silva Hamir Gonçalves da , Souza Patrick Gomes de , Pinheiro Clairon Lima
Published: August 2022

O mercado de cervejas artesanais vem implantar um grande crescimento nos últimos anos, com isso as cervejarias têm recorrido a novos estudos de inovação e tecnologia para produzir novos produtos. A utilização de recursos naturais é uma excelente alternativa para essa prática. O Brasil possui uma flora rica em diversidade biológica, com madeiras que podem conferir singularidade de aroma e sabor como cervejas do estilo Wood and Barrel Aged Beer. No presente estudo foram produzidas cervejas do estilo Wood and Barrel Old Beer tendo como base o estilo Scottish Ale Export com adição da madeira jatobá ( Hymenaea courbaril ) na etapa de maturação por 30 dias.As cervejas que foram maturadas com jatobá não obtiveram mudança na sua coloração, porém obtiveram um aumento significativo da turbidez, e dissipador de aroma alcoólico, que sobrepôs o aroma floral do lúpulo. Foi possível conquistar que o jatobá conferiu propriedades diferenciadas à cerveja, sendo assim uma boa opção para a produção de cervejas envelhecidas com madeira.
Herbal oils in healthcare: a review
Authors: Silva Luiz Everson da , Dotto Ana Rafaela Freitas
Published: August 2022

The herbal medicine market has grown considerably as an alternative currently used for the application of plants in the treatment of various diseases. In this environment, studies on the bioactivity of essential oils and the search for those that have antimicrobial, analgesic, anti-inflammatory, anti-tumor, antioxidant properties and also oils that can inhibit key enzymes are highlighted. However, research on the use of plants in the pharmaceutical industry, chemical composition of native species and possible biological activities are still scarce. Therefore, studies for the knowledge of native species with therapeutic potential gain great relevance. This study carried out a review of the research already done on essential oils from species with potentially promising biological activities for the contribution of the sustainable use of biodiversity and the relevance of their medicinal potential.
Hidrogéis a base da goma do cajueiro e poli(ácido acrílico) como potenciais fornecedores de água na agricultura
Authors: Soares José Hermeson da Silva
Published: August 2022

Duas séries de hidrogel denominadas HG1/HG2 constituídas do polissacarídeo goma do cajueiro (GC) e acrilato poli(ácido acrílico) com capacidade absorvente e de liberação controlada de água, foram preparadas por polimerização em solução aquosa na presença do agente reticulante N’N’-metileno-bis-acrilamida (MBA) e o iniciador reacional persulfato de potássio (KPS) sob aquecimento e variando a concentração de reticulante e monomérica. A goma do cajueiro foi purificada por precipitação em etanol e estudada quanto a parâmetros de teor de acidez, condutimetria, rendimento e aspectos macroscópicos.  Análises por infravermelho FTIR revelaram que a GC foi modificada a partir da inserção na cadeia de poli(ácido acrílico), e a reticulação entre cadeias se deu pela presença de MBA. A inserção da GC e a presença de grupos ácidos conferiram aos polímeros propriedades absorventes e de resposta a mudança de pH. Análises in vitro de intumescimento variando condições de pH, concentração salina em ciclos reversíveis forneceram informações quanto a degradabilidade através da formação de fase gel. O grau de absorção e liberação simulando aplicação no solo agrícola mostrou que os hidrogéis possuem potencial de aplicação como sistemas fornecedores de água, no entanto, o hidrogel com menores proporções monoméricas e de reticulante mostrou-se mais promissor.
As atribuições clínicas do farmacêutico na diminuição dos problemas relacionados aos medicamentos frente a automedicação por medicamentos isentos de prescrição comercializados em drogarias
Authors: Amorim Filho Hyrtacides de Oliveira Lima , Cavalcanti Jéssica Tamyris Freitas , Silva Thais Fernanda Melo Gomes da , Santana George Misael Ferreira de , Lima Januaria Rodrigues de , Da Silva Candido Thayna Rhomana , Lins Uiara Maria de Barros Lira , Silva Claudio Tejo da
Published: August 2022

Os medicamentos são uma das principais intervenções no curso da terapêutica do paciente, seja no tratamento ou prevenção de muitas enfermidades. A automedicação não tem uma definição universal, podendo ser desde a utilização de medicamentos isentos de prescrição ou a reutilização de medicamentos previamente prescritos pra uma determinada patologia. Este estudo constituiu-se de uma revisão de literatura, onde foram realizadas buscas utilizando como estratégia de pesquisa os seguintes descritores: Medicamentos isentos de prescrição, prescrição farmacêutica, farmácia clínica, automedicação, assistência farmacêutica, segurança do paciente, nos idiomas português e inglês. Os estudos tiveram seus conteúdos analisados qualitativamente. Os farmacêuticos têm uma responsabilidade profissional na prestação de serviços de alta qualidade para o paciente, portanto ele deve ter conhecimento atualizado da evidência para medicamentos sem tarja e estar preparado para discutir informações a respeito, contribuindo para as escolhas dos pacientes. A farmácia passou a configurar como um estabelecimento de saúde, aumentou assim o papel do farmacêutico como autoridade sanitaria.
A Literatura Nativa no Ensino de História: Novos olhares sobre os povos indígenas
Authors: Oliveira Elisa Faria de
Published: August 2022

O artigo em questão possui como tema a utilização da literatura nativa no ensino de história. De forma que as obras escritas e produzidas por indígenas são elementos essenciais de resistência desses povos, que buscam romper com estereótipos e denunciar violências. Sendo assim, a interrelação entre essa produção literária dentro das aulas de história nas escolas de ensino básico, auxiliariam nesse processo de discussão e reelaboração de uma nova metodologia de educação. Assim, podendo ser efetivado uma aula que vá além dos livros didáticos e que promova debates que viabilizam a quebra de rotulações. De modo, que as diferenças sejam respeitadas e os processos de opressões realizadas para com esses povos indígenas consigam ser abordadas. Em um procedimento que tenha como foco, o rever as ideias europeizadas e coloniais que vem excluindo grupos e ações de violências, em detrimento de uma narrativa que vem priorizando apenas a classe que é chamada de “dominante”.
A “soltura de memes” na prisão do ex-presidente Michel Temer (MDB-SP): o uso do humor e os temas evidenciados
Authors: Marques Rodolfo Silva , Conceição Bruno da Silva
Published: August 2022

No mês de março de 2019, o ex-Presidente da República Michel Temer (2016-2018), do MDB, foi preso, após operação da Polícia Federal, após decisão do juiz federal Marcelo Bretas (TRF2-RJ). A operação incluiu a prisão de vários outros políticos ligados a Michel Temer, como o ex-ministro e governador do Rio de Janeiro, Moreira Franco, e o coronel João Baptista Lima Filho. Em atos seguidos e articulados, a prisão de Temer gerou uma grande repercussão nos meios de comunicação, em especial na internet. Tal reflexo midiático se percebeu nos portais de notícias, buscando as causas e consequências das prisões, assim como na construção de vários memes, em geral com conotação jocosa, tratando, pejorativamente, da prisão do ex-presidente. No presente trabalho, busca-se a identificação de como houve o uso dos memes neste escândalo político, com desdobramentos para outras análises de casos. Aplica-se uma avaliação imagética, como caminho metodológico, para entender a rápida mobilização social no uso dos memes, em especial no caráter político, além do uso da revisão de literatura. Como conclusões, identifica-se o uso de memes de humor como forma de desqualificação da imagem do ex-presidente com algumas referências pejorativas ao entorno familiar de Temer, algo muito peculiar nesse tipo de evento.
Evaluation of angiogenic and embryotoxic activity of the extract of Anadenanthera peregrina (Angico-do-Cerrado)
Authors: Marinho Tamíris Augusto , Nunes Patrícia Silva , Lino Junior Ruy de Souza , Reis Paulo Roberto de Melo , Machado Mônica Rodrigues Ferreira , Silva Jr Nelson Jorge , Menezes Filho Antonio Carlos Pereira de , Ventura Matheus Vinicius Abadia
Published: August 2022

The genus Anadenanthera has been reported in the literature with antioxidant, anti-inflammatory, antimicrobial effect and healing action in wound treatment. The study aimed to evaluate, in vivo, the angiogenic and embryotoxic activities of A. peregrina extract. Angiogenesis in chicken embryo egg chorioallantoic membrane and zebrafish embryotoxicity was performed. A. peregrina extract at concentrations 62 mg mL-1 and 124 mg mL-1 were angiogenic. For embryotoxicity, the mortality rate increased with increasing concentration and increased dose and time dependent embryotoxicity was observed. The lethal concentration (LC50) ranged from 0.331mg mL-1 over the 24 hpf period to 0.007 mg mL-1 at 168 hpf (Δ% = -97.9), decreasing with increasing exposure. The heart rate decreased progressively and significantly with increasing concentration at all tested exposure times. In conclusion, it was evidenced that the extract of Anadenanthera peregrina has angiogenic activity. Nonetheless, embryotoxic effects were observed at high concentrations.