bluuebunny/crossref_metadata_2025 huggingface dataset:
Stenting of gastroduodenal artery pseudoaneurysm threatened rupture: report of a case
Authors: Do Kim Que , Tran Quy Tuong , Do Cao Duy Anh
Published: July 2024

Gastroduodenal artery (GDA) aneurysm is a rare surgical entity that causes various symptoms. In the case of rupture, it usually presents an ominous prognosis and mortality rate of up to 40%. Although open surgical procedure is a mainstay, endovascular intervention is emerging as a promising treatment in recent years, due to its advantages and safety.  We present a case of upper gastrointestinal bleeding caused by GDA pseudoaneurysm threatened rupture in a 72-year-old woman, with medical episodes of acute pancreatitis, a pancreatic body tumor removal surgery was performed, and now the tumor is relapsing and metastasizing. The treatment approach is blocking off the pseudoaneurysm by a covered stent. The procedure was successful and the patient is asymptomatic. Two months later, the pseudoaneurysm reduces its size and is completely excluded from the preservation of the blood flow in the artery. Endovascular interventional treatment in the case of GDA aneurysms is considered a promising alternative not only to open surgery but also to an effective emerging technique even in the acute setting.
Simple Aortopulmonary window: Outcomes of surgical repair at Vietnam National Children’s Hospital
Authors: Nguyen The Hai , Dang Thi Hai Van , Nguyen Thi Thu Hang , Nguyen Dinh Chien , Vu Thanh Ha , Do Van Nam , Nguyen Tuan Mai , Nguyen Thi Thanh Tam , Nguyen Ly Thinh Truong
Published: July 2024

Purpose: Evaluate the midterm outcomes of surgical repair for patients diagnosed with simple aortopulmonary window at Vietnam National Children’s Hospital.
Methods: We retrospective review data of patients who underwent surgical repair for simple aortopulmonary window from May 2014 to December 2023 at Vietnam National Children’s Hospital. Patients who had ventricular septal defect, interrupted aortic arch, aortic arch hypoplasia, double outlet of the right ventricle, or Berry syndrome were excluded from this study.
Results: There were 37 patients who underwent surgical repair in this study. The mean age at the time of surgery was 259.37 ± 702.59 days, and the mean weight was 5.04 ± 3.7 kg. According to the Society of Thoracic Surgeons Congenital Heart Database Committee classification, sixteen patients were type1, twelve were type2, and nine were type3. Two patients underwent ligated window, 3 had window division and sutures without bypass, and 32 had patch repair. There were 4 in-hospital deaths (10.8%), no late deaths, and no patients required cardiac reoperation during a mean follow-up of 62.09 ± 31.07 months.
Conclusions: Midterm survival beyond discharge of simple aortopulmonary window is excellent.
Mid-term outcomes of minimally invasive surgery for partial atrioventricular septal defect in children
Authors: Do Anh Tien , Nguyen Tran Thuy
Published: July 2024

Objective: This study aims to describe the mid-term outcomes of minimally invasive surgery for partial atrioventricular septal defect in children.
Summary: Partial atrioventricular septal defect is one of the three types of atrioventricular septal defect, accounting for about 3.5% of congenital heart disease. Traditionally, complete repair has been performed via sternotomy. However, with the advancement of minimally invasive surgical techniques in treating congenital heart conditions, we conducted this study to assess the feasibility and mid-term outcomes of this approach.
Subjects and methods: This descriptive study spanned from January 2018 to December 2023, involving 30 patients diagnosed with partial atrioventricular septal defect who underwent minimally invasive complete repair. The cohort comprised 12 males and 18 females, with an average age of 18 months and average weight of 10.3 kg. The mean diameter of the primary atrial septal defect was 15 mm. Eight patients (26.7%) exhibited moderate to severe mitral regurgitation, and the average pulmonary artery pressure was 37 mmHg.
Results: The average durations of cardiopulmonary bypass and aortic cross-clamp were  82 minutes and 58 minutes, respectively. None of the patients required sternotomy. The average time of artificial ventilator post-surgery was 6.9 hours, with a mean hospital stay of 7.6 days. Postoperative echocardiography showed promising results: complete closure of atrial septal defect, with 90% of patients having absent or mild mitral valve regurgitation, only 10% experienced moderate mitral valve regurgitation. The average follow-up period was 38 months, during which there were no postoperative fatalities. One patient required reoperation due to severe mitral regurgitation from an anterior cleft.
Conclusion: Minimally invasive surgery for partial atrioventricular septal defect in children can be safely performed, yielding favorable mid-term outcomes during follow-up.
Early outcomes of minimal invasive surgery via the axillary approach for complex congenital heart disease at the Cardiovascular Center - E hospital
Authors: Do Anh Tien , Luong Thi Nhu Huyen , Nguyen Tran Thuy
Published: July 2024

Objective: This study aims to outline the initial outcomes of implementing minimally invasive surgery via the right axillary approach to completely repair complex congenital heart diseases.
Summary: Minimally invasive surgical techniques have gained widespread adoption in managing simple congenital heart diseases such as atrial septal defect, ventricular septal defect, partial atrioventricular septal defect, cor triatriatum, and partial anomalous pulmonary venous return. Postoperative results have demonstrated equivalence, if not superiority, to traditional sternotomy procedures while offering enhanced cosmetic benefits. However, for more intricate congenital heart conditions such as tetralogy of Fallot (TOF), complete atrioventricular septal defect (CAVSD), and Ebstein syndrome, this study evaluates the early outcomes of employing minimally invasive surgery via the right axillary approach, a technique that remains relatively uncommon globally. Our study seeks to assess the initial outcomes of this approach in managing complex congenital heart diseases.
Subjects and methods: descriptive method based on  a series of cases. From April 2023 to December 2023, 45 patients diagnosed with complex congenital heart disease underwent minimally invasive surgery utilizing the axillary approach. This cohort comprised 40 patients with tetralogy of Fallot, 3 patients with complete atrioventricular septal defect, and 2 patients with Ebstein syndrome.
Results: All procedures were technically successful, without requiring sternotomy. The cardiopulmonary bypass times for the TOF, complete AVSD, and Ebstein syndrome groups were 81 minutes, 91 minutes, 96 minutes, respectively. Corresponding aortic cross - clamp times were 70 minutes, 72 minutes, and 74 minutes. There were no postoperative fatalities or significant  complications. Postoperative echocardiographic evaluations demonstrated favorable outcomes.
Conclusion: Minimally invasive surgery via the axillary approach for managing complex congenital heart diseases yields promising early results and offers notable cosmetic advantages.
Evaluation of the outcomes of noninvasive ventilation in acute heart failure patients at Cardiovascular Center – E hospital
Authors: Nguyen Dinh Hoan , Nguyen Thai Long , Nguyen Tran Thuy
Published: July 2024

Background: Noninvasive ventilation is indicated in patients with acute respiratory failure, especially in acute heart failure. The study aimed to evaluate the effectiveness of noninvasive ventilation in patients with acute heart failure.
Methods: The descriptive study on 23 patients with acute heart failure and respiratory failure who were applied non-invasive ventilation at Cardiovascular Center, E Hospital.
Results: The mean age of the patients was relatively high (74 years old), the rate of male accounted for 56.5%. The main causes were ischemic heart disease accounting for 82.6% and acute myocardial infarction accounting for 43.5%. Non-invasive ventilation improved the respiratory failure condition: gradually reducing respiratory rate, increasing SPO2, PaO2, and P/F ratio. In addition, it improved the hemodynamic status: increasing mean blood pressure, reducing heart rate and increasing tissue perfusion by reducing lactate level. The successful rate of noninvasive ventilation is 65.2% and the mortality rate is 21.7%.
Conclusion: Non-invasive ventilation is a simple respiratory support, easy to apply in many facilities to help improve respiratory condition and hemodynamic status.
Evaluate the results of anesthesia and resuscitation of minimally invasive surgery for pediatric patients with ventricular septal defect at Cardiovascular Center, E hospital in 2022
Authors: Pham Tuan Anh , Pham Thi Minh Hue , Vu Van Ba , Nguyen Tran Thuy
Published: July 2024

Objective: Minimally invasive surgery has recently been implemented safely and effectively on children. The study aimed to evaluate the results of anesthesia and resuscitation in pediatric patients with ventricular septal defects (VSD) undergoing minimally invasive surgery.
Methods: A cross-sectional study from January 1, 2021 to June 30, 2022 on 65 patients underwent minimally invasive surgery to repair ventricular septal defect, at Cardiovascular Center, E Hospital.
Result: A toltal of 65 children aged from 1 month to 34 months, mean weight of 9.0 ± 6.3kg, mean height of 73.6 ± 22.1cm, with main clinical symptoms of slow weight gain (62.5%) and grade I heart failure (87.7%). The most common VSD location was perimembranous VSD (67.7%) with an mean size of 5.7±2.6 mm. The mean surgical time was 175 minutes with cardiopulmonary bypass time and aortic cross-clamp time of 77.5 and 53.0 minutes, respectively. Postoperative hemodynamic parameters changed statistically significantly compared to pre-operation: blood pressure decreased, heart rate increased, lactate level  increased, P/F ratio decreased, blood potassium level decreased. The patient mainly needed to use 1 vasopressor, 1 type of sedative analgesic, continuous diuresis, and prophylactic antibiotics with a vasopressor withdrawal time of 34.2 hours, a sedation withdrawal time of 13.35 hours, and a sedative withdrawal time of 13.35 hours. Intubation time of 20.8 hours (minimum 2 hours) and length of stay ICU was 3.8 days. Postoperative complications were low, mainly pneumonia (9.2%) and residual shunt (9.2%), and no death was observed.
Conclusion: Minimally invasive ventricular septal defect surgery showed that the anesthesia and surgical process did not change much, with relatively fast post-operative recovery results, short medication time, quick recovery, and no recording severe complications.
Outcomes of endovascular intervention for infrarenal abdominal aortic aneurysm with hostile necks
Authors: Phan Son An , Tran Minh Bao Luan , Nguyen Huu Tuong , Phan Quoc Hung
Published: July 2024

Overview: Currently, endovascular intervention of the abdominal aortic aneurysm is considered the standard treatment method. Aneurysm neck’s morphology can affect 60% of the success or failure of endovascular intervention. Many advanced techniques to treat hostile necks have gradually become popular. However, endovascular intervention of the abdominal aortic aneurysms with hostile aneurysm necks are still considered a challenge.
Objectives: Describe the characteristics of patients with infrarenal abdominal aortic aneurysms with hostile necks. Evaluate the perioperative and mid-term outcomes of endovascular intervention to treat infrarenal abdominal aortic aneurysms with hostile necks.
Methods: The patients were diagnosed with infrarenal abdominal aortic aneurysms at the Vascular Surgery Department of Cho Ray Hospital, and were treated by endovascular intervention, from January 2020 to August 2023, and met the including criteria.
Results: The technical success rate was 95.12%. The early death rate was 2.44%. There were no aneurysm-related deaths. Early endoleak rate was low at 4.88%. Late type I endoleak was 7.5%. The mid-term mortality rate was 9.76%. The mid-term mortality rate recorded in the aneurysm necks length ≤ 15mm group was significantly higher than the other group. Late type I endoleak had no significant difference, when comparing the short neck groups and the angulated neck groups.
Conclusion: Endovascular intervention to treat infrarenal abdominal aortic aneurysms with hostile necks is a safe and effective method.
Early outcomes of total arch replacement in the treatment of aortic dissection
Authors: Nguyen Thai An , Mai Van Vien , Nguyen Huu Uoc
Published: July 2024

Abstract: Overview: Aortic dissection are severe pathologies with high mortality and complication rates post-surgery despite significant advancements in both diagnosis and surgical treatment. Aortic arch replacement surgery is a classic and highly effective treatment method at Cho Ray Hospital.
Objectives: Describe clinical, paraclinical characteristics, postoperative results, general complications and early hospital mortality.
Methods: Descriptive cross sectional study.
Results: 102 patients underwent aortic arch replacement surgery due to aortic dissection. Males predominated at 72.5%. The male:female ratio was 2.5:1. The average age was 56.45 ± 11.79 years. A history of hypertension was present in 81.4% of cases. Most patients with aortic dissection were admitted in an acute condition, accounting for 95%. Patients with type A aortic dissection accounted for 87.3%, with the entry tear in the ascending aorta at 27.5%. Isolated aortic arch replacement was performed in 46.1% of patients, while 53.9% underwent aortic arch replacement with frozen elephant trunk technique. 7 patients required aortic root replacement, 7 needed aortic valve surgery, and 10 required CABG. Most patients were cooled to 25 degrees C with cerebral perfusion to three branches. Ascending aorta cannulation was established in 45.2% of cases. The average cardiopulmonary bypass time was 257.7 minutes, with selective cerebral perfusion time at 115.9 minutes and lower body circulatory arrest time averaging 57.2 minutes. Postoperative neurological complications occurred in 10.8%, and the rate of renal failure requiring dialysis was 17.8%. The mortality rate was 9.6%. Longer cardiopulmonary bypass times and body temperatures above 25 degrees significantly increased the rate of postoperative renal failure requiring dialysis. Patients with postoperative renal failure requiring dialysis had a statistically significant increase in postoperative mortality rates. Aortic root intervention surgery combined with arch replacement did not affect the rate of postoperative complications. Aortic arch replacement with frozen elephant trunk technique did not affect cardiopulmonary bypass time, clamping time, or the rate of postoperative complications.
Conclusions: Total arch replacement at Cho Ray Hospital initially showed a safe and effective with acceptable mortality rate.
Effective strategies for teaching philological disciplines: practicalc ases and Innovative approaches
Authors: Varvaruk Inna , Sakhnevych Inna , Hasiuk Nataliia , Muzika Tetiana , Lada Oleksandr
Published: July 2024

This article delves into the expediency of exploring effective strategies for teaching philological disciplines, emphasizing the critical importance of innovative approaches in modern educational practices. As the field of philology continues to evolve, the relevance of enhancing teaching methodologies to meet the diverse learning needs of students becomes increasingly evident. The primary objective of this study is to investigate practical cases and innovative approaches that can significantly impact the pedagogical landscape of philological education. Utilizing a qualitative research approach, the article examines the efficacy of implementing various teaching strategies in philological disciplines and their implications for student engagement and academic performance. Through case studies and theoretical analysis, the research reveals the effectiveness of interactive teaching methods, collaborative learning activities, and technology integration in philological education. The results highlight the potential for these innovative approaches to enhance student comprehension, critical thinking skills, and overall academic achievement, ultimately contributing to the advancement of teaching practices in philological disciplines. The practical and theoretical significance of these findings lies in the increased efficiency and effectiveness of teaching methods, leading to improved learning outcomes and student success in the field of philology.
Advanced Survey of Blockchain for the Internet of Things Smart Home
Authors: Pratheeksha Shetty  , Prof. Jayanth Kumar Rathod  , Sanika Gowda  , Drushya Hegde  , Niriksha Rai
Published: July 2024

"The Internet of Things (IoT) has many uses, like making homes smarter. But a big problem with IoT is that it relies too much on a central server, which can be risky. Blockchain, a new kind of system where everyone shares control, can fix this issue. Smart homes face lots of security problems, like hackers and privacy concerns. Blockchain is helpful here too, making sure data and transactions are safe. This paper talks about using Blockchain in smart homes, breaking it down into three main parts. It explains how Blockchain can protect data and transactions, and talks about the security of IoT smart homes.".
An Improve Method for Plant Leaf Disease Detection and Classification using Deep Learning
Authors: Jeetendra Mahor  , Ashish Gupta
Published: July 2024

In countries like India, whose important occupation is agriculture, face a huge loss when the crops get affected by any type of disease. These diseases attack the crops in various stages and can destroy the entire production. Since most diseases are transmitted from one crop to another there is an essential requirement to detect the type of disease in the early stage so that farmers can take the required action to “save the crops” and production. Early disease detection is one of the essential activities for enhancing agricultural productivity. Diseases spread very quickly in the parts of the leaves that affect the growth of the plants. Early detection is a challenging task as the symptoms are mild for accurate identification. This research paper presents an enhanced CNN based MCC-ECNN model with fine-tuned hyper-parameters and various batch sizes for accurate plant leaf disease classification.
Never Say “NO”
(Strategies for Nurses to Communicate Politely)
Authors: Capt. Usha Banerjee  , Ms. D. Maryline Flinsi
Published: July 2024

Effective communication is the cornerstone of quality patient care and nurses are essential in fostering understanding, compassion, and respect in their interactions with patients, families, and other healthcare professionals. In the current healthcare system, one of the frequent complaints that patients express on post-discharge satisfaction surveys is rude behavior of the staff. By directly saying “NO”, nurses make patients to feel unwanted and neglected. Many times, this neglect has landed in the loss of patient attachment and lead to an increased risk of liability and dissatisfaction. In this article the impact of saying no to the patient and alternative strategiesof saying no has been discussed
Network pharmacology and in vitro experiments reveal the autophagy mechanism of Yanggan-Yishui granules in improving hypertensive renal injury
Authors: Liu Pan , Hu Tairan , Gao Bing , Xia Ran , Dai Xiaohua , Wang Jing
Published: July 2024

Introduction

In China, Yanggan-Yishui granules (YGYSG) have been used to treat hypertensive renal damage (HRD) for over 20 years. Network pharmacology was used to determine whether YGYSG affects HRD via the autophagy pathway, which was verified using in vitro experiments.

Material and methods

Common targets of YGYSG, HRD, and the autophagy pathway were screened using network pharmacology, and effective compounds, core targets, and signaling pathways were identified. The affinity of the compounds for the core targets was evaluated using molecular docking simulations. Angiotensin II (Ang II) was used to generate an in vitro renal podocyte model using MPC-5 cells. Morphological changes in the autophagosomes were observed using transmission electron microscopy (TEM). The expression levels of autophagy-related and pathway proteins were detected using western blotting and reverse transcription quantitative real-time PCR (PCR).

Results

Network pharmacology and molecular docking analyses identified eight autophagy-related core targets and ten core components in the YGYSG treatment of HRD. These targets are mainly involved in the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway and autophagy-related biological processes. In vitro experiments showed that Ang II-stimulated renal podocytes exhibited abnormal autophagy, and YGYSG protected renal podocytes from abnormal autophagy. In addition, YGYSG reversed abnormal autophagy and improved HRD by activating the PI3K/AKT/mTOR signaling pathway.

Conclusions

YGYSG may regulate abnormal autophagy in renal podocytes by activating the PI3K/AKT/mTOR signaling pathway and may play a role in improving HRD.
Association between inflammatory cytokines and prostate cancer
Authors: Li Sheng , Zhou Libing , Wu Tielin , Xu Jianting , Long Huimin , Cao Lin
Published: July 2024

Introduction

We conducted bidirectional two-sample Mendelian Randomization (MR) analysis to investigate the causal relationship between 91 inflammatory cytokines and prostate cancer (PCa).

Material and methods

The Inverse Variance Weighted (IVW) model served as the primary two-sample MR analysis method, utilized to estimate the causal effect of exposure on the outcome. The Weighted Median (WM) and MR Egger methods were additionally employed to complement the IVW model. Sensitivity analyses were performed using Cochran's Q test for both the IVW and MR Egger methods. To assess the presence of horizontal pleiotropy, the instrumental variables (IVs) were subjected to the MR-Egger intercept test.

Results

Following Bonferroni correction, the IVW analysis revealed positive correlations between PCa and the levels of C-C motif chemokine 20 (CCL20), C-C motif chemokine 23 (CCL23), fibroblast growth factor 19 (FGF19), fibroblast growth factor 23 (FGF23), and interleukin-6 (IL-6). Notably, IL-6 exhibited the strongest positive association effect (odds ratio [95% confidence interval]: 1.0076 [1.0014, 1.0139]), followed by CCL-20 (1.0067 [1.0004, 1.0129]) and FGF23 ([1.0002, 1.0119]). Reverse MR analysis indicated a negative causal relationship between PCa and interleukin-22 receptor subunit alpha-1 levels (IL22RA1) (0.4852 [0.2390, 0.9847]).

Conclusions

This study proposes that there exists a positive correlation between the levels of CCL20, CCL23, FGF19, FGF23, and IL-6 and the occurrence of PCa. Furthermore, we found evidence to support the causal relationship between decreased levels of IL22RA1 and the development of PCa. These findings unveil novel biomarkers and pathways that could potentially be targeted for the prevention and clinical treatment of PCa.
Mesenchymal Stem Cells Suppress Kidney Injury molecule-1 Associated with Inhibition of Renal PKC/ NF-Kβ / STAT3 Fibrotic Signaling Pathway in Rats with Diabetic Nephropathy
Authors: Ebrahim Hasnaa A. , AlMohanna Asmaa Mohammed , Shati Ayed A. , Alshehri Mohammed A. , A-Elgadir Thoraya Mohamed Elhassan , Almohaimeed Hailah M. , Haidara Mohamed A. , Hosny Sara Adel , Dawood Amal , ShamsEldeeen Asmaa M.
Published: July 2024

Introduction

Background: Diabetes stands as the predominant etiology behind end-stage kidney disease, commonly referred to as renal failure. The intricate interplay among oxidative stress, inflammation, and renal fibrotic changes in diabetes-induced nephropathy, particularly in instances involving and not involving the administration of mesenchymal stem cells (MSCs), remains a subject less explored in existing research.

Material and methods

Methods: Twenty-four male Wistar rats (180 and 200 grams) were randomly assigned to one of three groups (n = 8). The control group received standard laboratory chow, and the groups with T2DM received a single dose of streptozotocin, 45 mg/kg, after three weeks of pretreatment with a high-fat diet (HFD). Rats with T2DM were split into the T2DM model group and Bone marrow (BM) mesenchymal stem cells (MSCs) treated group (T2DM+MSCs) eight weeks after DM was confirmed. BM-MSCs were injected systemically at 2 × 106 cells/rat doses.

Results

Results: Diabetes significantly altered oxidative stress (MDA, SOD), inflammation (TNFα, IL-6), and kidney injury (KIM-1, NAGAL) biomarkers, a modulation that was mitigated by MSCs (p < 0.0001). Furthermore, diabetes-induced kidney fibrosis showed a noteworthy reduction in the presence of MSCs. A notable correlation emerged between body weight, systolic blood pressure (SBP), oxidative stress, inflammation, fibrosis, the PKC/NF-KB/STAT-3 axis, and hyperglycemia.

Conclusions

Conclusions: Our results suggest that diabetes was associated with elevated oxidative stress, inflammation, biomarkers of kidney injury, upregulation of the renal PKC/NF-KB/STAT-3 pathway, and hypertension, all countered by MSCs intervention.
A Retrospective Analysis of the Association of Obesity with Anthracycline and Trastuzumab-Induced Cardiotoxicity in the Treatment of Breast Cancer and Lymphoma
Authors: Huff Mallorie L , Gupta Ranju , Gupta Rahul , Schadler Kelly C , Duka Shae , Histon-Figliolini Vienna , Kalter Joshua , Joshi Amogh M , Ahmad Nadeem V , Aronow Wilbert S , Sundlof Deborah W
Published: July 2024

Introduction

Background:
Trastuzumab and anthracyclines are mainstays of chemotherapy in breast cancer and lymphoma patients. We aimed to assess the relationship between obesity and the risk of developing chemotherapy-associated cardiotoxicity.

Material and methods

A retrospective chart review was conducted of all patients who received trastuzumab or anthracyclines at our tertiary care center. Bivariate analyses were conducted to determine the association between demographic and clinical variables with cardiotoxicity status. Two multivariate logistic regression models were generated to assess whether BMI was independently associated with cardiotoxicity.

Results

Of the 368 patients receiving either trastuzumab or anthracyclines, 16 patients developed cardiotoxicity. Demographically, age, race, BMI, BSA, and weight did not differ between the patients who developed cardiotoxicity and those who did not. The mean dose of anthracycline and trastuzumab did not differ between the patients who developed cardiotoxicity and those who did not. Obesity was not found to increase the odds of developing cardiotoxicity and was slightly protective. A non-significant decrease in the odds of developing cardiotoxicity was found for every one-unit increase in BMI. In a multivariable model using BMI as a continuous predictor and controlling for BMI, age, hypertension, chemotherapy type and coronary artery disease, the only significant predictor of cardiotoxicity was a previous history of arrhythmia.

Conclusions

Obesity was not a significant risk factor for patients developing cardiotoxicity from trastuzumab or anthracycline based chemotherapy and may be a protective factor for cardiotoxicity. Additional studies with greater statistical power are needed to further evaluate this effect and independently evaluate obesity as a risk factor for cardiotoxicity.
The SP1/SNHG16/GLUT1 axis promotes prostate cancer proliferation and invasion by regulating glucose metabolism
Authors: Huang Hua , Zhang Wen
Published: July 2024

Introduction

The SP1/SNHG16/GLUT1 is involved in diverse cancer-related process. This study was designed to study the role of SP1/SNHG16/GLUT1 axis in prostate cancer (PCa) via modulation of glucose metabolism.

Material and methods

The expression profile of SNHG16 in PCa tissues was obtained from the online public database GEPIA (http://gepia.cancer-pku.cn/). Real-time qPCR was used to ascertain the mRNA expression. To find cellular proliferation and invasion, respectively, CCK-8, transwell, and glycolysis were used to monitor proliferation, invasion, and glycolysis.

Results

Analysis of GEPIA2 data revealed upregulation of SNHG16 in PCa tissues and a positive association between GLUT1 (SLC2A1) and SP1/SNHG16 expression in the correlation study. Consistently, SPI and SNHG16 were either overexpressed or knocked down in PCa cells to unveil the role of the SP1/SNHG16/GLUT1 axis. Results demonstrated that PC-3 and DU145 cell proliferation were promoted by the overexpression of either SPI or SNHG16. On the other hand, PC-3 and DU145 cell proliferation were reduced upon knockdown of SP1 or SNHG16. A real-time qPCR study revealed that GLUT1 mRNA was upregulated by SP1/SNHG16 overexpression and downregulated by SP1/SNHG16 knockdown. In PCa cells, overexpression of SNHG16/SP1 resulted in enhanced utilization of glucose, lactose, and ATP production, whereas SNHG16/SP1 knockdown had the reverse effect. Lastly, transwell assay results showed that overexpression of SNHG16/SP1 promoted, while knockdown of SNHG16/SP1 inhibited the invasiveness of PC-3 and DU145 PCa cells.

Conclusions

Collectively, the SP1/SNHG16/GLUT1 axis regulates the proliferation of PCa cells via the glycolytic route and thus may act as a therapeutic target for PCa treatment.
Learning Loss Dynamics in Grade II Islamic Education Learning at SD Muhammadiyah Pahandut Palangka Raya
Authors: Tu'aini Tu’aini , Romelah Romelah
Published: July 2024

The loss of learners' ability to receive knowledge transfer from teachers during the learning process is called learning loss. This phenomenon can cause the loss of students' abilities in the cognitive, affective, and psychomotor domains. This study aims to look at learning loss in PAI learning at Muhammadiyah Pahandut Elementary School in Palangka Raya City. The research method used is a case study with a descriptive qualitative approach and field research. Data collection techniques were observation, interview, and documentation. While data analysis techniques use source triangulation, data validation techniques include data collection, reduction, presentation and conclusion drawing. Based on the results of this study, it was found that there was a learning loss, there were students who were not fluent in reciting the Koran, difficulty in writing Hijaiyah letters and difficulty understanding PAI learning materials related to Jurisprudence material.
Pengembangan Media Pembelajaran Berbasis Web Google Sites pada Pembelajaran IPS Kelas V SDN Cinangka 5 Depok
Authors: Syahrani Lidya , Gunawan Rudy
Published: July 2024

Harus ada inovasi dan kreativitas dari para pendidik dalam merancang pembelajaran, dan salah satu caranya adalah dengan memanfaatkan media pembelajaran. Karena sifat teoretis dari pelajaran IPS, yang mungkin membuat anak-anak sekolah dasar cepat bosan, materi pembelajaran yang menarik dan berkualitas tinggi sangat penting untuk topik ini. Guru dapat memanfaatkan ide dan antusiasme Peserta didiknya untuk belajar melalui penggunaan materi pembelajaran yang menarik. Tujuan utama penelitian ini adalah untuk memfasilitasi pemahaman Peserta didik terhadap materi IPS dan meningkatkan keterlibatan kelas untuk menghasilkan pembelajaran bermakna melalui pembuatan materi pengajaran autentik di Google Sites. Analisis, desain, pengembangan, implementasi, dan evaluasi adalah lima langkah yang membentuk metodologi ADDIE yang digunakan dalam penelitian ini. Beranda, Kompetensi Dasar, Absensi, Materi, dan Permainan merupakan menu utama portal pembelajaran Google Sites. Respon Peserta didik terhadap media pembelajaran Google Sites sebesar 94,25%, sedangkan temuan validasi dari ahli media sebesar 92% dengan kategori “sangat valid” dan sebesar 83,33% dari ahli materi. Hasil evaluasi menunjukkan bahwa Google Sites merupakan alat pembelajaran IPS kelas lima yang efektif dan mudah digunakan.
Signifikansi Aspek Kompetensi Pedagogik Guru terhadap Pembelajaran Bahasa Inggris pada Siswa Sekolah Menengah Kejuruan Pertanian
Authors: Astuti Widya Puji , Robandi Babang
Published: July 2024

Penelitian ini bertujuan untuk mengelaborasi keselarasan relasi antara aspek teoritis kompetensi pedagogik guru dan temuan sebenarnya pada penyelenggaraan pembelajaran Bahasa Inggris di jenjang Sekolah Menengah Kejuruan. Penelitian ini menggunakan metode deksriptif kualitatif. Teknik pengumpulan data menggunakan observasi langsung dengan subjek penelitian seorang guru mata pelajaran Bahasa Inggris di kelas ATPH 3 Jurusan Pertanian di SMKN Pacet Cianjur. Prosedur analisis data pada penelitian ini adalah identifikasi teoritis, analisis data, reduksi data, interpretasi akhir dan verifikasi. Hasil penelitian menunjukkan bahwa: (1) Kompetensi pedagogik guru dalam persiapan proses pembelajaran yang dilakukan oleh guru pada kelas kelas ATPH 3 Jurusan Pertanian di SMKN Pacet Cianjur menunjukkan signifikansi yang sesuai dengan kompetensi guru yang dimiliki. Hal ini terlihat dari keseluruhan persiapan pra pembelajaran dilakukan secara struktural dan terdapat kelengkapan pembelajaran yang sesuai. Mulai dari RPP, games, lembar kerja siswa, absensi dan lain lain. (2) Kompetensi pedagogik guru ketika pembelajaran berlangsung paa kelas ATPH 3 Jurusan Pertanian di SMKN Pacet Cianjur menunjukan signifikansi yang baik karena guru telah mengimplementasikan apersepsi pembelajaran, adanya alur komunikatif yang meningkatkan keterlibatan siswa. Namun belum terlihat relevansi pembelajaran Bahasa Inggris dengan jurusan peminatan siswa dengan pembelajaran. (3) Kompetensi pedagogik guru ketika pelaksanaan refleksi sudah baik dan signifikansi ketiga elemen dari aspek-aspek kompetensi pedagogik guru ini sudah terepresentasi dalam proses pembelajaran dari awal hingga akhir.
Pengembangan Media Komik Petualangan Wong Banten untuk Kelas IV Sekolah Dasar di Cilegon
Authors: Goliah Mafdurotul , Hendrayana Aan , Leksono Suroso Mukti
Published: July 2024

Tergerusnya bahasa daerah menjadi salah satu permasalahan yang patut diatasi oleh segala kalangan, baik dari keluarga, lembaga pendidikan, maupun pemerintah. Salah satu cara yang dilakukan pemerintah untuk mengatasi tergerusnya bahasa Jawa Cilegon ialah dengan mewajibkan pembelajaran Nalek (Bahasa Jawa Cilegon) di Sekolah Dasar, namun faktanya pelaksanaan pada pembelajaran belum optimal karena kurangnya media pendukung yang dapat digunakan dalam pembelajaran Nalek tersebut. Tujuan penelitian ini untuk mengembangkan media komik petualangan Wong Banten dalam meningkatkan literasi berbahasa Jawa Cilegon untuk kelas IV Sekolah Dasar di Cilegon. Adapun metode penelitian yang digunakan ialah metode penelitian pengembangan dengan model ADDIE yang memiliki lima tahapan, yakni: Analysis, Design, Development, Implementation, dan Evaluate. Teknik dan cara pengumpulan data yang digunakan dalam penelitian ini adalah wawancara dan angket, adapun analisis data yang digunakan menggunakan deskriptif kualitatif dan kuantitatif. Hasil penelitian pengembangan ini ialah mendapat nilai kelayakan dari ahli materi sebesar 98,64% dengan kategori sangat baik, ahli media sebesar 85% dengan kategori baik, ahli bahasa sebesar 94,28% dengan kategori sangat baik, dan angket respon peserta didik sebesar 79% dengan kategori baik. Berdasarkan hasil tersebut, media komik petualangan Wong Banten dapat dikatakan layak untuk digunakan peserta didik pada pembelajaran Nalek kelas IV Sekolah Dasar di Cilegon. Hasil dari pengembangan media komik petualangan Wong Banten ini diharapkan dapat disebarluaskan dan digunakan menjadi media pembelajaran bahasa Jawa Cilegon di Cilegon.
Pengaruh Model Pembelajaran Problem Based Learning terhadap Kemampuan Berpikir Kritis Materi Bahasa Indonesia Siswa Kelas IV
Authors: Maheswara Rivana , Rosidi Muhib
Published: July 2024

Anak-anak Indonesia harus memiliki keterampilan yang komprehensif untuk bersaing secara global, termasuk komunikasi yang efektif, kemampuan berpikir kritis, bermoral, bertanggung jawab sebagai warga negara, toleransi, dan kemampuan beradaptasi di tingkat global. Guru dapat menerapkan model pembelajaran berbasis masalah yang melibatkan penyelidikan nyata, analisis, identifikasi masalah, hipotesis, percobaan, dan penyimpulan untuk membangun keterampilan yang komprehensif . Tujuan dari penelitian ini adalah untuk mengetahui bagaimana siswa kelas IV di SDN Kemayoran 13 menggunakan kemampuan berpikir kritis yang dipengaruhi oleh pembelajaran dengan model berbasis masalah. Melalui penggunaan metode desain quasi-experiment yang populasi ada sekitar 33 siswa yang dipisahkan menjadi kelompok eksperimen dan kelompok kontrol. Dilakukannya observasi awal serta tes uraian untuk mengumpulkan data. Uji homogenitas, normalitas, dan hipotesis digunakan dalam analisis data, sedangkan penyajian data dengan memakai tabel. Penelitian ini menunjukkan hasil penggunaan paradigma berbasis masalah pada pembelajaran meningkatkan kapasitas siswa untuk berpikir kritis pada mata pelajaran Bahasa Indonesia siswa kelas IV di SDN Kemayoran 13. Hal ini ditunjukkan dengan analisis uji-t yang menghasilkan data dengan nilai signifikansi 2-tailed sebesar 0,000 < 0,05, yang mengarah pada kesimpulan bahwa H0 ditolak dan Ha diterima. Temuan ini menunjukkan bahwa paradigma pengajaran dengan model berbasis masalah berpengaruh pada cara berpikir kritis siswa kelas IV SDN Kemayoran 13.
Analisis Kebutuhan LKPD Berbasis Model Apresiasi pada Pembelajaran Apresiasi Puisi di Sekolah Dasar
Authors: Syarifatunnisa Ayu , Apriliya Seni , Setiadi Pidi Mohamad
Published: July 2024

Lembar Kerja Peserta Didik (LKPD) jarang sekali digunakan dalam pembelajaran khususnya pada pembelajaran apresiasi puisi. Hal ini diperlukan untuk pengembangan LKPD agar sesuai dengan syarat penyusunan LKPD dan pengintegrasian model apresiasi pada LKPD. Tujuan penelitian untuk memaparkan hasil analisis kebutuhan LKPD berbasis model apresiasi dalam pembelajaran puisi. Pendekatan yang dipilih dalam penelitian adalah kualitatif dengan metode pengumpulan data melalui observasi pasif, wawancara terstruktur, dan analisi konten dokumen. Penelitian dilakukan di 3 Sekolah Dasar di Kota Tasikmalaya, partisipan diambil dari peserta didik dan guru kelas IV. Hasil dari penelitian ditemukan bahwa: (1) pembelajaran belum mengarah pada tahap mengapresiasi puisi dimana peserta didik hanya difokuskan pada teori, menulis dan membaca puisi; (2) pembelajaran belum menggunakan model apresiasi sastra; dan (3) hanya 1 dari 3 SD yang menggunakan LKPD dalam pembelajaran apresiasi puisi serta belum mengintegrasikan model apresiasi pada LKPD. Hasil penelitian yang telah dipaparkan akan berdampak pada proses pembelajaran apresiasi puisi menjadi kurang optimal, maka dari itu diperlukan pengembangan LKPD berbasis model apresiasi.
Pengembangan Media Interaktif Berbasis Educandy Match-Up pada Materi Pecahan untuk Meningkatkan Numerasi Peserta Didik Kelas IV
Authors: Dewi Dyah Ayu Buana Tungga , Nurafni Nurafni
Published: July 2024

Penelitian ini dilatar belakangi oleh keadaan kelas yang masih dilakukan secara konvensional yang mana guru menggunakan metode ceramah sehingga kondisi kelas kurang aktif pada saat proses pembelajaran berlangsung yang menyebabkan kurangnya numerasi peserta didik. Dari permasalahan diatas, peneliti berinisiatif untuk mengembangkan sebuah media pembelajaran berbasis Educandy Match-Up untuk meningkatkan numerasi peserta didik. Keunggulan yang bisa didapatkan dari pengembangan media interaktif ini yaitu menciptakan suasana belajar yang lebih aktif sehingga memotivasi peserta didik untuk semangat dalam belajar khususnya pada mata pelajaran Mat\ematika. Tujuan penelitian ini adalah terdapatnya media interaktif berbasis Educandy Match-Up yang layak dengan kriteria valid dan efektif dalam meningkatkan numerasi untuk peserta didik kelas IV. Penelitian ini menggunakan ADDIE yang merupakan suatu model yang didalamnya mempresentasikan tahapan-tahapan secara sistematis. Sampel penelitian ini sebanyak tujuh puluh satu peserta didik kelas empat dari SDN Ciracas 06 dan SDN Cinangka 05. Kuesioner dan nilai post-test dari kelas kontrol dan eksperimen digunakan untuk mengumpulkan data. Hasil penelitian menunjukkan bahwa media interaktif berbasis Educandy Match-Up valid dengan persentase sebesar 90,48% diperoleh dari ahli materi dan 95,83% diperoleh dari ahli media, hasil respon peserta didik terhadap media pembelajaran memperoleh persentase sebesar 82,78%, dan hasil post test pada kelas kontrol mendapatkan skor persentase sebesar 75,45% dan pada kelas ekperimen mendapatkan skor persentase sebesar 81,48%. Pengembangan media interaktif berbasis Educandy Match-Up ini dinyatakan valid dan layak digunakan untuk meningkatkan numerasi peserta didik kelas IV pada materi pecahan.
Peningkatan Pemahaman Konsep Perkalian dan Pembagian Pecahan melalui Pendekatan Matematika Realistik Berbantuan Alat Peraga Papan Ajaib
Authors: Trengganis Lia Fitriani , Maulana M , Irawati Riana
Published: July 2024

Kurangnya pemahaman konseptual siswa terhadap konten pecahan adalah kekuatan pendorong di balik penelitian ini, yang berupaya mengatasi masalah ini melalui pengajaran yang dapat meningkatkan pemahaman konseptual siswa. Salah satunya adalah penggunaan alat peraga papan ajaib yang dipadukan dengan pendekatan matematika realistik. Dengan penggunaan prosedur matematika realistik termasuk alat peraga papan ajaib, penelitian ini berupaya untuk memastikan sejauh mana siswa memahami perkalian dan pembagian pecahan, serta memberikan penjelasan atas kemajuan tersebut. Menggunakan jenis penelitian nonequivalent control group dan teknik penelitian kuantitatif, penelitian ini menggunakan desain eksperimen semu. Partisipan dalam penelitian ini adalah siswa kelas V SDN Cimalaka III dan SDN Citimun II. Alat penilaian ini mengukur kemampuan subjek dalam menangkap ide-ide abstrak. Rata-rata, keterampilan pemahaman konsep siswa meningkat masing-masing sebesar 72,21% dan 66,76% ketika diajarkan matematika menggunakan metode matematika realistik dibandingkan dengan pendekatan tradisional, menurut penelitian. Pemahaman konseptual siswa kelas V dapat ditingkatkan dengan penggunaan alat bantu pengajaran dan pendekatan pembelajaran matematika realistis. Rata-rata, kelompok eksperimen memiliki N-Gain sebesar 0,5674, sedangkan kelompok kontrol memiliki 0,4184. Hal ini menunjukkan bahwa dibandingkan dengan kelompok kontrol, siswa pada kelompok eksperimen memperoleh 0,149 pengetahuan konseptual lebih besar. Sederhananya, siswa kelompok eksperimen yang diajar konsep matematika menggunakan pendekatan realistik dengan menggunakan papan ajaib memiliki pemahaman materi yang lebih baik dibandingkan kelompok kontrol yang diajar menggunakan pendekatan yang lebih tradisional.
Missing Concept Image dan Mis-in Concept Image pada Materi Segi Empat Ditinjau dari Gaya Kognitif
Authors: Pamarna Agustine Dwi Kurniawati , Juandi Dadang , Jupri Al
Published: July 2024

Hubungan antara jenis segi empat adalah salah satu konsep yang harus dikuasai siswa dalam materi segi empat. Akan tetapi, berdasarkan studi literatur, banyak siswa yang masih melakukan kesalahan dalam menentukan hubungan antara jenis segi empat. Penelitian ini bertujuan untuk mendeskripsikan missing concept image dan mis-in concept image dalam materi segi empat. Missing concept image terjadi ketika contoh dari suatu konsep dikategorikan sebagai bukan contoh dari konsep tersebut sedangkan mis-in concept image ketika bukan contoh dari suatu konsep dikategorikan sebagai contoh dari konsep tersebut. Faktor yang dapat memengaruhi pembentukan concept image siswa adalah gaya kognitif. Penelitian ini menggunakan desain penelitian kualitatif dengan pendekatan fenomenologi hermeneutik. Subyek penelitian ini adalah dua siswa kelas VII, masing-masing dengan gaya kognitif field-dependent dan field-independent. Penelitian ini menggunakan dua instrumen yaitu instrumen tes GEFT untuk menentukan tipe gaya kognitif siswa dan instrumen tes dengan tipe soal two-tier multiple-choice untuk memahami concept image siswa terhadap hubungan antara jenis segi empat. Hasil penelitian menunjukkan bahwa terjadi missing concept image dan mis-in concept image pada siswa dengan gaya kognitif field-dependent sedangkan pada siswa dengan gaya kognitif field-independent terjadi mis-in concept image. Hasil penelitian ini diharapkan dapat menjadi bahan pertimbangan dalam merancang pembelajaran yang dapat meminimalisir kesalahan concept image.
Pengaruh Model Problem-based Learning terhadap Kemampuan Pemecahan Masalah Matematis Siswa
Authors: Putri Detya Eka Nurwanty , Maulana Maulana , Irawati Riana
Published: July 2024

Permasalahan rendahnya kemampuan pemecahan masalah matematis siswa yang terjadi di lapangan dapat diatasi dengan memilih model pembelajaran yang tepat sebagai upaya yang dapat dilakukan untuk meningkatkan kemampuan pemecahan masalah. Model problem-based learning merupakan model pembelajaran yang relevan untuk meningkatkan kemampuan pemecahan masalah. Penelitian ini bertujuan untuk mengetahui perbedaan pengaruh model problem-based learning dan pembelajaran konvensional terhadap kemampuan pemecah masalah matematis siswa. Penelitian ini menggunakan metode eksperimen dengan nonequivalent control group design. Populasi penelitian adalah siswa kelas IV SD terakreditasi A di Kecamatan Cimalaka dengan sampel siswa kelas IV SDN Margamukti sebagai kelas eksperimen dan siswa kelas IV SDN Licin sebagai kelas kontrol. Instrumen berupa tes uraian digunakan untuk mengukur kemampuan pemecahan masalah matematis. Hasil menunjukkan penerapan model problem-based learning berpengaruh secara signifikan. Hasil nilai rata-rata pretest 45 menjadi 82 pada posttest dan nilai rata-rata gain 0,63. Sedangkan pembelajaran konvensional memperoleh nilai rata-rata pretest 52 menjadi 76 pada posttest dengan nilai rata-rata gain 0,46 sehingga model problem-based learning lebih efektif daripada pembelajaran konvensional, terbukti dengan nilai rata-rata gain problem-based learning yang lebih tinggi.
Mengidentifikasi Kebutuhan Pengembangan Modul Ajar Apresiasi Puisi di SD
Authors: Rahmawati Elfa , Apriliya Seni , Merliana Anggit
Published: July 2024

Penggunaan modul ajar oleh beberapa pendidik di kelas IV Sekolah Dasar (SD) pada pembelajaran apresiasi puisi belum menggunakan model pembelajaran yang dikhususkan. Namun, masih menggunakan model pembelajaran secara umum. Maka penelitian ini dilakukan untuk mengidentifikasi dan menganalisis kebutuhan modul ajar, kemudian akan dikembangkan pada pembelajaran apresiasi puisi di kelas IV SD. Metode yang digunakan yaitu kualitatif deskriptif. Subjek pada penelitian ini yaitu pendidik dan modul ajar bahasa Indonesia. Penelitian dilakukan bulan Februari-Maret 2024 pada dua SD yang ada di Kota Tasikmalaya. Peneliti pengumpulan data dengan melakukan kegiatan observasi, wawancara, dan analisis konten modul ajar. Analisis data dengan menggunakan model Miles dan Huberman melibatkan tiga tahap utama: reduksi data, pennyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa: (1) komponen pada modul ajar yang digunakan belum sesuai dengan komponen dalam Badan Standar Kurikulum dan Asesmen Pendidikan Nomor 003/H/KR/2022; (2) tidak adanya model pembelajaran yang dikhususkan dalam pembelajaran apresiasi puisi; dan (3) pada pembelajaran apresiasi puisi pendidik belum mengarah pada mengapresiasi isi puisi. Dari hasil penelitian perlu dikembangkan modul ajar apresiasi puisi dengan menggunakan model khusus. Maka dari itu, peneliti menyarankan dalam membuat modul ajar seharusnya memperhatikan komponen-komponen dalam modul ajar, model pembelajaran yang digunakan, materi yang akan dipelajari, dan kebutuhan yang dibutuhkan oleh peserta didik agar pembelajaran sesuai dengan tujuan yang akan dicapai dan pembelajaran menjadi lebih efektif dan efesien.