bluuebunny/crossref_metadata_2025 huggingface dataset:
Advancements in Retail Price Optimization: Leveraging Machine Learning Models for Profitability and Competitiveness
Authors: Mohammad Anisur Rahman  , Chinmoy Modak  , Md Abu Sufian Mozumder  , Mohammed Nazmul Islam Miah  , Mehedi Hasan  , Md Murshid Reja Sweet  , Roy Syeda Farjana Farabi , Md Zikar Hossan  , Roy Mani Prabha , Mahfuz Alam
Published: May 2024

Retail price optimization is essential for maximizing profitability and maintaining competitiveness in today's dynamic retail landscape. This study addresses retail price optimization as a regression problem, utilizing machine learning models to predict optimal price points for products. Leveraging factors such as product attributes, competitor pricing dynamics, and customer behaviors, regression analysis provides a structured approach to understanding the intricate relationships between variables. Among various regression techniques, the Random Forest Regressor emerges as a potent strategy, offering robustness and versatility in tackling complex pricing tasks. Results indicate that Random Forest outperforms Decision Tree and Logistic Regression models regarding accuracy, precision, recall, and overall predictive performance. With Random Forest achieving an accuracy of 94%, it demonstrates superior capability in capturing complex data patterns and making accurate predictions of retail prices. By leveraging advanced analytics and machine learning techniques, retailers can optimize pricing strategies, maximize profits, and maintain competitiveness in the market. This study underscores the importance of continuously analyzing and refining pricing strategies to gain a competitive edge in the retail landscape.
The Effect of Bacillus Pumilus on the Free Swell and Atterberg Limits of Black Cotton Soil for use in Road Subgrades
Authors: John Godwin
Published: May 2024

The study evaluated the potential utilisation of Bacillus pumilus (B. pumilus) induced calcite precipitate for the improvement of the engineering properties of black cotton soil in road construction which is an eco-friendly technique and forms part of what is referred to as green engineering. The effect of B. pumilus on the free swell and Atterberg limits of black cotton soil for use in road subgrades was studied using microbial induced calcite precipitation (MICP) method. Five stepped B. pumilus suspension density of 0, 1.5 x 108, 6.0 x 108, 1.2 x 109, 1.8 x 109 and 2.4 x 109 cells/ml, respectively, were utilized for the treated specimens, while only cementitious reagent acted as the control specimen. Three (3) mix ratios of % Bacteria suspension (B) - %Cementitious reagent (C) (i.e., 25B - 75C, 50B - 50C and 75B - 25C) were adopted. It was observed that free swell treated with 25B - 75C decreased from 70 % and 50 % for the natural and control specimens, respectively, to minimum value of 46 %, with increasing B. pumilus suspension density at 2.4 × 109 cells/ml. Atterberg limits results showed liquid limit values decreased from 53 % and 62 % for the natural and control samples, respectively, to  43 % for samples treated with 25B - 75C at B. pumilus suspension density of 2.4 x 109 cells/ml, while the plastic limit increased from 28.2 % for the control soil sample to 30 %  for the 75B - 25C mix ratio at B. pumilus suspension density of 2.4 x 109 cells/ml. Tests results indicated a considerable improvement with 25B - 75C mix ratio at B. pumilus suspension density of 2.4 × 109 cells/ml which significantly reduced the free swell, while the Atterberg limits fell below Nigerian General Specifications requirements of not greater than 35% Liquid limit, 12% Plasticity index and 35% passing No.200 sieve for utilization as road subgrades. However, it could be used as a subgrade material in low-volume roads.
Comparasion of HVAC Energy Consumption Prediction in an Academic Building using LSTM and DNN
Authors: Christian Hadi , Friansa Koko , Pradipta Justin , Haq Irsyad Nashirul , Leksono Edi
Published: May 2024

Energy consumption information is a collection of information obtained from datasets that is useful for making decisions for energy conservation. In this paper, we proposed a modern approach based on LSTM and DNN. While many researchers have employed these methods for predicting energy consumption, this paper seeks to compare their efficacy to determine which is superior. The comparative analysis in question employs accuracy metrics such as Mean Absolute Error (MAE), Mean Squared Error (MSE), Root Mean Squared Error (RMSE), and R-squared (R2) values. Furthermore, the accuracy metric outcomes indicate that the LSTM method surpasses the DNN approach in terms of the R-squared (R2) value, with respective scores of 0.931 and 0.782. Meanwhile, for other accuracy metrics, the DNN method outperforms LSTM. Nevertheless, the performance of the two proposed methods is excellent, as evidenced by the R-squared (R2) value exceeding 0.75, which aligns with modeling standards observed in numerous research studies.
ОСНОВНІ НАПРЯМКИ ДОСЛІДЖЕННЯ МОТИВАЦІЇ У ПСИХОЛОГІЇ: ЗАРУБІЖНИЙ ДИСКУРС
Authors: Ременюк Я.
Published: May 2024

Як виявилось, загальноприйнятої, єдиної, повністю задовільної класифікації мотивів та її ієрархічної структури на сьогодні немає. Дослідники по-різному розуміють, що таке мотив, і, крім того, від самого початку мають різні наукові підходи до розв'язання цієї проблеми. Однак загальне системне уявлення про мотиваційну сферу людини дозволяє дослідникам класифікувати мотиви, але підстави для цих класифікацій є різними.
ПРОКРАСТИНАЦІЯ СЕРЕД СТУДЕНТСЬКОЇ МОЛОДІ: РЕЗУЛЬТАТИ ДОСЛІДЖЕННЯ
Authors: Шиделко А. , Мачита А.
Published: May 2024

У статті висвітлено результати емпіричного дослідження явища прокрастинації у середовищі студентської молоді за такими психодіагностичними методиками: методика «Шкала загальної прокрастинації» К. Лей; тест «Оцінка рівня ситуативної (реактивної) тривожності» Спілбергера-Ханіна; методика «Діагностики особистості на мотивацію до уникнення невдач» Т. Елерса; методика «Страх негативної оцінки» (BFNE-S); тест-опитувальник самоорганізації діяльності (ОСД) Фріцо Капра.
РОЛЬ КЕРІВНИКА-ЛІДЕРА В ФОРМУВАННІ ОРГАНІЗАЦІЙНОЇ КУЛЬТУРИ
Authors: Каменюк Ю.
Published: May 2024

В статті досліджено основні засади організаційної культури, роль і місце лідерства до процесів управління в організації. Зокрема акцентується увага на роботі керівника-лідера зі створення ефективної організаційної культури та вдосконаленні лідерських якостей, здійснено їх опис. Запропоновано модель організаційної культури та її складові. Визначено необхідні заходи у формуванні успішної організаційної культури та шляхи їх практичної реалізації у сучасних умовах України.
ГРУПОВА ПСИХОДИНАМІЧНА ТЕРАПІЯ У ДЕРЖАВНИХ КЛІНІКАХ ЄВРОПИ: ОГЛЯД ЕМПІРИЧНИХ ДОСЛІДЖЕНЬ
Authors: Кириченко Владислав
Published: May 2024

У запропонованій статті розглянуто опис методів та стилів роботи групових психотерапевтів у державних спеціалізованих відділеннях Данії, Іспанії та Норвегії, а також зазначено обґрунтування результатів їх роботи терапевтичним ефектом. При огляді переваг та недоліків методології проведення психодинамічних малих груп у згаданих країнах, проведено паралелі щодо перспективи впровадження цих методів в Україні.
Ключові слова: психодинамічна терапія; групова психотерапія; психодинамічні групи; психотерапія; психодинаміка; психоаналіз.
Вступ. Психодинамічною є терапія, в основу якої покладений психологічний детермінізм, віра в позасвідомі процеси психіки, а також переконання, що людська поведінка є динамічною та цілеспрямованою (Alonso, 1989). Базовим традиційним психодинамічним інструментом в роботі терапевтичних груп є вільне асоціювання. Динамічний погляд на вільне асоціювання передбачає, що вільно асоціюючи, пацієнт зіштовхнеться з зоною внутрішнього конфлікту – у груповій терапії це носить назву «груповий процес». Груповий психотерапевт припускає, що зміна самими пацієнтами тем обговорення протікає крізь призму позасвідомих зв'язків між пацієнтами, тому терапевт не встановлює порядок денний, а слідує асоціаціям групи. Існує переконання, що груповий процес неминуче зіштовхнеться з найбільш важливим та афективно насиченим матеріалом, якщо не впливати на обговорення (Rutan, 1992). Психодинамічна групова психотерапія покращує стан здоров’я навіть сильно уражених пацієнтів (Jensen, Mortensen & Lotz, 2010).
Незважаючи на значущі результати групової психодинамічної роботи за кордоном, в Україні не зустрічаються публікації, які б описували власне груповий клінічний досвід, при тому, що групова робота є вигідною не лише через підвищення показників ментального здоров’я та соціалізації пацієнтів державних клінічних закладів, а є доцільною також і з точки зору ресурсного розподілу: за проміжок часу в 50-90 хвилин психотерапевт працює одразу з 6-12 людьми натомість консультації з одним пацієнтом. Доцільне використання ресурсу в роботі з хворобами психіки у державних клініках є вкрай актуальним для країни, що перебуває в стані війни. Коректний розподіл такого ресурсу включає не лише економічну привабливість, а й екзистенційну значимість.
Мета дослідження полягає у визначенні принципів та маркерів успішності роботи групової психодинамічної терапії, яку застосовують в державних амбулаторіях країн Європи та у формулюванні алгоритму впровадження позитивного іноземного досвіду в клініках суміжного типу України. Мета включає такі завдання: опис роботи групової динамічної терапії на основі данського дослідження (Jensen, Mortensen & Lotz, 2010), іспанського дослідження (Lana et al., 2015), а також норвезького дослідження (Fjeldstad, Høglend, & Lorentzen, 2017); аналіз ефективності цих досліджень та оцінка щодо впровадження їх результатів в Україні.
ОСОБЛИВОСТІ ДИСТАНЦІЙНОЇ ПСИХОДІАГНОСТИКИ ПСИХІЧНИХ СТАНІВ І ПРОФЕСІЙНОГО ЗДОРОВ'Я ФАХІВЦІВ
Authors: Корольчук В. , Корольчук М. , Кривда К. , Науменко Н.
Published: May 2024

Використання дистанційної психодіагностики фахівців за допомогою Google Forms дає підстави з’ясувати об’єктивні і суб’єктивні чинники і прояви негативних психічних станів у обстежуваних, а також чинники професійного здоров’я під час пандемії або війни.
Це дає можливість використати різні варіанти динамічної оцінки результатів, статистичної обробки, підвищити об'єктивність психодіагностичних методик і звільнити психолога від рутинної роботи.
ДОСЛІДЖЕННЯ ОСОБЛИВОСТЕЙ МІЖОСОБИСТІСНОГО СПІЛКУВАННЯ КУРСАНТІВ ВІЙСЬКОВОГО ВИШУ
Authors: Павелко І. , Моторний В. , В’яткін Ю.
Published: May 2024

Встановлено, що основними стилями міжособистісного спілкування курсантів є: владно-лідуючий стиль; співпрацюючи-конвенційний стиль та відповідально-великодушний стилі міжособистісного спілкування. Досліджено, що використання обсценної лексики у спілкуванні курсантів є результатом мовленнєвої та комунікативної некомпетентності. Обґрунтовано, що мовленнєва компетентність в освітньому та виховному процесах є одним з найважливіших особистісних утворень майбутніх офіцерів.
Validity and Reliability of the Thai version of the International Consultation on Incontinence Questionnaire – Female Lower Urinary Tract Symptoms Long Form (ICIQ-FLUTS LF) and Its Correlation with the IPSS
Authors: Tohroonglert Parm , Swatesutipan Valeerat
Published: May 2024

Objective: Incontinence Modular Questionnaire on Female Lower Urinary Tract Symptoms Long form (ICIQ-FLUTS LF) is a robust psychometric tool to assess the severity of lower urinary tract symptoms (LUTS) in women. A Thai language version of the ICIQ-FLUTS LF is available, but it had not been validated yet. This study aimed to validate the ICIQ-FLUTS LF questionnaire in Thai and to identify the correlation between the ICIQ-FLUTS LF and the IPSS.
Materials and Methods: We recruited 130 females, 50 with LUTS were recruited from patients visiting the Urology Clinic to assess the test with known group validity. They completed the ICIQ-FLUTS LF twice, two weeks apart, and the IPSS once. Meanwhile, 80 without LUTS (control group) were recruited from relatives of the patients to increase the consistency of the statistical analysis, completed the ICIQ-FLUTS LF. Then validity and reliability were determined using statistical analysis.
Results: Convergent validity showed a moderate correlation between ICIQ-FLUTS LF and IPSS for both storage and voiding symptoms, with Pearson’s correlation coefficient 0.49, 0.66; P<0.001, respectively. Construct validity, using the Wilcoxon signed-rank test, demonstrated statistically significant difference between the target group and the control group (P<0.001). The Thai version of the ICIQ-FLUTS LF showed good internal consistency, with Cronbach’s alpha coefficients 0.76-0.79 and Test–retest reliability strong, with weighted kappa values 0.63 to 0.90.
Conclusion: The Thai version of the ICIQ-FLUTS LF shows good validity and reliable measures of females with LUTS, and is simple to use. This questionnaire in the Thai version can be used in clinical practice and academic research.
Safety of outpatient management of cancer-associated pulmonary embolism: a retrospective study
Authors: Pradier Michelle , Wang Tzu-Fei , Siegal Deborah M. , Le Gal Grégoire , Carrier Marc , Delluc Aurélien
Published: May 2024

Not available.
Nova ocorrência de Balanophoraceae na Bahia, Brasil
Authors: Santos Guilherme Keven Ferreira dos , Rando Juliana Gastaldello
Published: May 2024

O presente artigo traz uma nova ocorrência de uma espécie de Balanophoraceae, uma holoparasita de raiz, na região Oeste do Estado da Bahia, Brasil. Helosis cayanensis foi coletada no povoado de Itaculumim, zona rural, no município de Angical, registrada pela primeira vez na região e no Estado. Essa nova ocorrência contribui para o aumento da diversidade de espécies no Estado e amplia a área de ocorrência da espécie para o Brasil. Este trabalho também apresenta informações da morfologia, chave de identificação para os gêneros de Balanophoraceae e para as espécies de Helosis ocorrentes na Bahia, imagens e um mapa com a distribuição  das duas espécies de Helosis com ocorrência no Estado.
Türkiye’deki Akademisyenlerin Yapay Zekâ (YZ) Uygulama ve Araçlarını Kullanımları Hakkında Bir Araştırma
Authors: Ünal Cihan , Yıldırım Hakan
Published: May 2024

Bu makale, Türkiye'deki akademisyenlerin Yapay Zekâ (YZ) ürünlerini (uygulama ve araçlarını) kullanma alışkanlıklarını ve kullanım nedenlerini inceleyen bir araştırmanın sonuçlarını sunmaktadır. Veriler, geniş bir akademik topluluğun katılımıyla gerçekleştirilen bir anket aracılığıyla toplanmıştır. Bulgular, YZ konusunda yeterli farkındalık olduğunu, YZ ürünlerinin kullanıldığını ancak YZ ürünlerinin yeterince yaygın ve çok yönlü bir şekilde kullanılmadığını göstermektedir. Araştırmayla YZ kullanımının yaygınlığı, etkisi ve gelecekteki araştırmalar için potansiyel yönleri, beraberinde getirdiği telif, patent ve mahremiyet ihlali gibi yeni sorunları matematiksel bulgularla ortaya konmuş ve sonuçları tartışılmıştır. Bu çalışma, YZ teknolojilerinin akademik çalışmalar ve öğretimdeki rolünün anlaşılması ve daha yaygın kullanımı için katkıda bulunmayı amaçlamaktadır.
Preclinical models and IgA anti-GD2 antibody therapy for neuroblastoma
Authors:   , Stip Marjolein C.
Published: May 2024

The thesis of Marjolein Stip discusses the potential of IgA anti-GD2 antibody therapy as a treatment for neuroblastoma. Neuroblastoma is one of the most common tumors in children. It arises during embryonic development, usually in the adrenal glands or nervous system in the belly. Low- and intermediate-risk patients can get better spontaneously and otherwise respond well to surgical removal. However, high-risk patients face a grim prognosis with a 5-year survival rate of only 45%.
Standard treatments for high-risk neuroblastoma include chemotherapy, surgery, stem cell transplantation and radiotherapy. Additionally, patients can receive immunotherapy. This immunotherapy consists of IgG antibodies against GD2 - a sugar-lipid molecule - expressed by neuroblastoma cells. When these antibodies bind GD2 on neuroblastoma cells, they activate immune cells, most importantly NK cells, which then attack the tumor. However, this therapy can cause severe neuropathic pain, since it is also recognizing GD2 that is expressed on nerves. When IgG anti-GD2 antibodies bind to these nerves, they activate the complement system, causing severe pain.
In this thesis the development of IgA as an alternative to IgG antibodies for immunotherapy is discussed. IgA antibodies activate so-called myeloid immune cells via the FcαRI receptor, such as neutrophils, monocytes and macrophages. This offers advantages, since experiments in mouse models showed that IgA antibodies do not activate the complement system and therefore do not induce neuropathic pain. This could be a great improvement in patient care.
Next to that, experiments demonstrated that IgA antibodies effectively target neuroblastoma cells by activating myeloid cells, mostly neutrophils. Neutrophils are very numerous and they are ‘the kamikaze fighters of the immune system’, as prof. Jeanette Leusen named them during her inaugural lecture. In both neuroblastoma cell lines and mouse models, IgA antibody therapy induced tumor cell death mediated by neutrophils.
The final chapter of the thesis explores a combination therapy with agents that block the CD47-SIRPα pathway to enhance the efficacy of IgA immunotherapy. This CD47-SIRPα pathway inhibits the activation of myeloid cells, and is often hijacked by neuroblastoma to protect itself from destruction. Blocking the CD47-SIRPα axis supports IgA antibody therapy by improving tumor cell killing by neutrophils and macrophages. Altogether, this thesis describes a viable alternative for IgG anti-GD2 antibody therapy with IgA antibodies and has propelled it towards clinical application.
“To Lie Convincingly”: Legal Challenges at the Intersection of Diplomacy and Foreign Interference
Authors: Walker-Munro Brendan
Published: May 2024

This article explores some of the legal challenges that arise in resolving disputes between diplomatic functions in an environment characterised by a growing desire of states to prevent foreign states from interfering in their internal affairs. In exposing some of the tensions involving diplomatic interference, the article suggests that diplomatic interference can be whatever the receiving state wishes it to be. It also proposes that states who enact protections against foreign interference are inter alia, perhaps unintentionally, closing the gaps between international and domestic law when it comes to what it means to “interfere” in a state’s internal affairs. The article closes by examining some law reforms that could be adopted by states to ensure that their legal regimes appropriately limit the risks of foreign interference and promote greater compliance by diplomatic staff.
Dental Licensure Exams Involving Human Subjects — What Is the Justification?
Authors: Recker Frank R
Published: May 2024

In his commentary, Dr. Recker presents the perspective of a licensed dentist, former dental board member, licensure examiner, and attorney and concludes that a dental licensing exam using a human subject is wholly unjustified and, in fact, primitive. He offers a provocative reason for their continued use, writing that it is "blind adherence to the past ... and the millions of dollars received by regional testing agencies."
Using Human Subjects in Dental Licensing Exams: Is This the Best Way to Ensure the Health and Safety of the Public?
Authors: Schloss Alexander
Published: May 2024

Alexander J. Schloss provides a comprehensive ethical framework in which to consider this question. Utilizing the ADA's 2018 Principles of Ethics and Code of Professional Conduct, Dr. Schloss systematically argues that it is not possible to uphold the principles of autonomy, nonmaleficence, beneficence, justice, and veracity enshrined in that code when human subjects are used in dental licensing exams.
A Note from the 2017 Chair of the Academy of Distinguished Educators and the JADE Editorial Board Chair
Authors: Spivakovsky Silvia
Published: May 2024

This issue of the Journal of the Academy of Distinguished Educators (JADE) focuses on the challenge of global oral health disparities and the importance of preparing students to address the lived reality of communities in need of dental education and care, both globally and locally.
The Dental Education Bubble: Are we ready for a LEED-style rating?
Authors: Bertolami Charles N
Published: May 2024

In his provocative centerpiece article, titled "The Dental Education Bubble: Are We Ready for a LEED-Style Rating?" Charles N. Bertolami uses the LEED rating system as a prototype that, in his own words, could be adapted to dental education in order to give dental school applicants, faculty members, governmental officials, the media, and the public a more open and honest appraisal of what a given educational program has to offer and what the educational product is really expected to be."
How Educational Technology Can Help Support Sound Pedagogical Approaches and Practices
Authors: Moran Lillian
Published: May 2024

In "How Educational Technology Can Help Support Sound Pedagogical Approaches and Practices," Lillian Moran suggests a path forward based on an analysis of who, what, how we teach, whether it is all aligned, and how academic institutions can cultivate a "growth mindset culture."
Sharing EHR Data Is Essential for Precision Medicine
Authors: Ramoni Rachel B.
Published: May 2024

In "Sharing EHR Data is Essential for Precision Medicine," Dr. Rachel Rumoni posits that every dental clinic and medical-care facility fully shared their data, then, as a totality, these data would be profoundly more valuable and useful than they are in isolation.
A Note from the 2016 Chair of the Academy of Distinguished Educators
Authors: Veitz-Keenan Analia
Published: May 2024

This issue looks at how the blending of these two worlds may have an impact both on learning for our students and teaching for our faculty. Included in the Journal are the viewpoints of experts on the challenges ahead.
A Note from the JADE Editorial Board Chair
Authors: Spivakovsky Silvia E.
Published: May 2024

This issue of the Journal of the Academy of Distinguished Educators (JADE) asks the question: Can educational technology transform learning outcomes? Three individuals with expertise and experience in this area make the case that the answer is more nuanced than it may at first appear.
Can Yerba Maté (Ilex paraguariensis A.-St.-Hil) and Its Constituents Affect Health and Obesity?
Authors: Sirotkin Alexander V.
Published: May 2024

The present commentary is a short narrative review of the available data concerning the influence of Yerba Maté, its relatives and constituents on health with special attention to its anti-obesity effects and their physiological mechanisms. The possible adverse side-effects of Yerba Maté, form and doses of its consumption are discussed. The available information demonstrates the ability of Yerba Maté and its constituents to prevent and to treat a wide array of disorders including obesity, although the potential of this plant to promote weight loss requires further elucidation.
Impact of CBTI on Cerebral Glucose Metabolism
Authors: Kay Daniel , Buysse Daniel , Karim Helmet
Published: May 2024

Somnoimaging is an approach in sleep medicine that combines neuroimaging techniques with established sleep research methods to better characterize sleep-wake states and study sleep-related constructs across those states. We used the fludeoxyglucose positron emission tomography (FDG-PET) method to investigate how CBTI impacted cerebral glucose metabolism during sleep and wakefulness in individuals with insomnia (N=27). We replicated previous findings suggesting that CBTI improves self-reported symptoms of insomnia and dysfunctional beliefs about sleep but found no significant differences in whole-brain or voxel-wise relative regional glucose metabolism as a result of CBTI. Followup analyses showed that (1) participants with greater pre-to-post treatment reduction in dysfunctional beliefs about sleep had a significant increase in relative glucose metabolism in the caudate following treatment, (2) individuals with greater relative glucose metabolism in the precentral gyrus at baseline had higher insomnia severity post-treatment, and (3) participants who experienced greater pre-to-post treatment reduction in insomnia severity following treatment had a more pronounced sleep-wake difference in relative glucose metabolism in the precuneus. Our findings may suggest that (1) targeting dysfunctional beliefs about sleep during CBTI may help normalize caudate nucleus activity across sleep-wake states, (2) greater relative glucose metabolism in the precentral gyrus may represent a biomarker of hyperarousal that predicts poorer response to CBTI, and (3) successful CBTI restores the polarity of relative glucose metabolism across sleep-wake states in individuals with insomnia in the posterior hotzone of consciousness.
PERSEPSI MASYARAKAT TERHADAP KERETA API GERBONG EKONOMI AC
Authors: Shinta Marlina Rahmi , Raharjo Agung , Mutiah Tuty
Published: May 2024

Penelitian ini berjudul Persepsi Masyarakat Terhadap Kereta Api Ekonomi. Penelitian ini bertujuan mengetahui pola pikir masyarakat terhadap kereta api ekonomi. Saya menggunakan metode wawancara dan literatur untuk membuat Penelitian ini. Dengan beberapa referensi, saya menyusun penelitian ini berdasarkan fakta yang ada dan pengalaman para narasumber. Saya berpikiran bahwa masyarakat memiliki persepsi buruk tentang kereta api ekonomi karena berbagai sebab. Setelah dilakukan penelitian, hasilnya adalah terbukti bahwa masyarakat mempunyai pola pikir buruk terhadap kereta api, tetapi, pola pikir tersebut dapat diubah dengan sosialisasi dan publikasi yang diikuti dengan peningkatan pelayanan.
ANALISIS SPECIAL EVENT SEBAGAI STRATEGI MAJALAH FORBES INDONESIA DALAM MENJALIN HUBUNGAN BAIK DENGAN PUBLIKNYA DI ERA PANDEMI COVID-19
Authors: Leonardi Aska
Published: May 2024

Penelitian ini bertujuan untuk mengetahui bagaimana strategi Forbes Indonesia dalam menjalin hubungan baik dengan publiknya di era pandemi melalui pelaksanaan special event. Metode yang digunakan dalam penelitian ini adalah kualitatif yang menggunakan teknik sampling Purposive Sampling dengan satu orang sebagai key informan dan satu orang sebagai supporting key informan. Pengumpulan data dilakukan dengan menggunakan wawancara, sedangkan metode analisis data yang digunakan adalah reduksi data, penyajian data, dan verifikasi data. Hasil penelitian menunjukkan bahwa strategi yang diterapkan Forbes Indonesia dalam menjalin hubungan baik dengan publiknya melalui special event berjalan dengan lancar. Keberhasilan special event bertajuk Inspiring Women 2020 Women in Tech: SMEs and The New Normal adalah dilihat dari penyusunan jadwal yang matang, peserta yang mencapai 300 orang sehingga melebihi ekspektasi, serta tercapainya tujuan penyelenggaraan, yaitu selain sebagai sarana menjalin hubungan baik dengan publiknya, Special Event: Inspiring Women 2020 juga memotivasi perempuan Indonesia dan UMKM Indonesia untuk bangkit dan cepat beradaptasi dengan kondisi pandemi Covid-19 saat ini.Kata Kunci: Strategi Humas, Acara Spesial, Hubungan Baik Dengan Publik.
Konstruksi Pesan Yang Terkandung Pada Iklan Gojek Edisi Ramadhan “Cerita Hikayat Sang Musafir – eBadah” di YouTube dan Televisi (Analisis Framing William A. Gamson dan Andre Modigliani)
Authors: Tambunan Resman Muharul
Published: May 2024

Menghadapi kebijakan pembatasan sosial ditengah pandemi Covid-19, komunikasi massasebagaisarana penyampaian informasi kepada khalayak. Salah satunyamelalui media iklan. Iklan Gojek Edisi Ramadhan di tengah pandemi berjudul “Cerita Hikayat Sang Musafir - eBadah” bertujuan untuk memperkenalkan fitur eBadah (ibadah secara virtual) melalui YouTube dan televisi. Proses penyampaian pesan melalui media menggiring khalayak menuju kondisi tertentu sesuai yang diinginkan oleh komunikator. Perangkat analisis pada penelitian ini adalah teori framing model William A. Gamson dan Andre Modligiani, terdiri dari visual image dan depiction dalam membentuk konstruksi pesan melalui representasi media. Data didapatkan melalui pengecekan ulang terhadap informasi yang diperoleh dengan melakukan wawancara kepada pihak Gojek secara mendalam. Proses pengolahan data menggunakan paradigma kosntruktivis danmetodekualitatif deskriptif.            Hasil penelitian,adanya kekuatan media dalam mengkonstruksi realitas yang dibentuk. Framing YouTube dan Televisi menjadi berbeda didasarkan perubahan durasi, adegan, pengisi suara dan pesan yang disampaikan. Realitas sosial dipindahkan ke dalam pesan media YouTube dan Televisi sehingga mengubah citra dan konstruksi pesan. Pesan yang disampaikan oleh produser pada iklan di YouTube mengenai isu yang di angkat dari desa kecil pada masa awal Covid-19 muncul, pesan-pesan tersebut bertujuan mempengaruhi komunikan kearah sikap menjalankan protokol kesehatan menjaga jarak, menggunakan masker serta melakukan kebiasaan ibadah virtual menggunakan aplikasi Gojek.Sedangkan pesan iklan televisi mengarah pada penggunaan fitur GoFood dan GoGive sebagai produk yang baik guna menunjang e-Badah.Iklan Gojek bertemakan kegiatan sehari-hari di tengah pandemi disampaikan melalui gawaidan televisi dengan cerita lebih menarik kepada khalayak.
5-HTP inhibits eosinophilia via intracellular endothelial 5-HTRs; SNPs in 5-HTRs associate with asthmatic lung function
Authors: Walker Matthew T. , Bloodworth Jeffrey C. , Kountz Timothy S. , McCarty Samantha L. , Green Jeremy E. , Ferrie Ryan P. , Campbell Jackson A. , Averill Samantha H. , Beckman Kenneth B. , Grammer Leslie C. , Eng Celeste , Avila Pedro C. , Farber Harold J. , Rodriguez-Cintron William , Rodriguez-Santana Jose R. , Serebrisky Denise , Thyne Shannon M. , Seibold Max A. , Burchard Esteban G. , Kumar Rajesh , Cook-Mills Joan M.
Published: May 2024

Background

Previous research showed that 5-hydroxytryptophan (5HTP), a metabolic precursor of serotonin, reduces allergic lung inflammation by inhibiting eosinophil migration across endothelial monolayers.

Objective

It is unknown if serotonin receptors are involved in mediating this 5HTP function or if serotonin receptor (HTR) single nucleotide polymorphisms (SNPs) associate with lung function in humans.

Methods

Serotonin receptor subtypes were assessed by qPCR, western blot, confocal microscopy, pharmacological inhibitors and siRNA knockdown. HTR SNPs were assessed in two cohorts.

Results

Pharmacological inhibition or siRNA knockdown of the serotonin receptors HTR1A or HTR1B in endothelial cells abrogated the inhibitory effects of 5HTP on eosinophil transendothelial migration. In contrast, eosinophil transendothelial migration was not inhibited by siRNA knockdown of HTR1A or HTR1B in eosinophils. Surprisingly, these HTRs were intracellular in endothelial cells and an extracellular supplementation with serotonin did not inhibit eosinophil transendothelial migration. This is consistent with the inability of serotonin to cross membranes, the lack of selective serotonin reuptake receptors on endothelial cells, and the studies showing minimal impact of selective serotonin reuptake inhibitors on asthma. To extend our HTR studies to humans with asthma, we examined the CHIRAH and GALA cohorts for HTR SNPs that affect HTR function or are associated with behavior disorders. A polygenic index of SNPs in HTRs was associated with lower lung function in asthmatics.

Conclusions

Serotonin receptors mediate 5HTP inhibition of transendothelial migration and HTR SNPs associate with lower lung function. These results may serve to aid in design of novel interventions for allergic inflammation.
Analysis of fluid force and flow fields during gliding in swimming using smoothed particle hydrodynamics method
Authors: Liu Meng-Meng , Yu Chuan-Wen , Meng Qing-Hua , Hao Xiao-Fan , Chen Zhi-Long , He Ming
Published: May 2024

Gliding is a crucial phase in swimming, yet the understanding of fluid force and flow fields during gliding remains incomplete. This study analyzes gliding through Computational Fluid Dynamics simulations. Specifically, a numerical model based on the Smoothed Particle Hydrodynamics (SPH) method for flow-object interactions is established. Fluid motion is governed by continuity, Navier-Stokes, state, and displacement equations. Modified dynamic boundary particles are used to implement solid boundaries, and steady and uniform flows are generated with inflow and outflow conditions. The reliability of the SPH model is validated by replicating a documented laboratory experiment on a circular cylinder advancing steadily beneath a free surface. Reasonable agreement is observed between the numerical and experimental drag force and lift force. After the validation, the SPH model is employed to analyze the passive drag, vertical force, and pitching moment acting on a streamlined gliding 2D swimmer model as well as the surrounding velocity and vorticity fields, spanning gliding velocities from 1 m/s to 2.5 m/s, submergence depths from 0.2 m to 1 m, and attack angles from −10° to 10°. The results indicate that with the increasing gliding velocity, passive drag and pitching moment increase whereas vertical force decreases. The wake flow and free surface demonstrate signs of instability. Conversely, as the submergence depth increases, there is a decrease in passive drag and pitching moment, accompanied by an increase in vertical force. The undulation of the free surface and its interference in flow fields diminish. With the increase in the attack angle, passive drag and vertical force decrease whereas pitching moment increases, along with the alteration in wake direction and the increasing complexity of the free surface. These outcomes offer valuable insights into gliding dynamics, furnishing swimmers with a scientific basis for selecting appropriate submergence depth and attack angle.
Deciphering the microbial landscape of lower respiratory tract infections: insights from metagenomics and machine learning
Authors: Li Jiahuan , Xiong Anying , Wang Junyi , Wu Xue , Bai Lingling , Zhang Lei , He Xiang , Li Guoping
Published: May 2024

Background

Lower respiratory tract infections represent prevalent ailments. Nonetheless, current comprehension of the microbial ecosystems within the lower respiratory tract remains incomplete and necessitates further comprehensive assessment. Leveraging the advancements in metagenomic next-generation sequencing (mNGS) technology alongside the emergence of machine learning, it is now viable to compare the attributes of lower respiratory tract microbial communities among patients across diverse age groups, diseases, and infection types.

Method

We collected bronchoalveolar lavage fluid samples from 138 patients diagnosed with lower respiratory tract infections and conducted mNGS to characterize the lung microbiota. Employing various machine learning algorithms, we investigated the correlation of key bacteria in patients with concurrent bronchiectasis and developed a predictive model for hospitalization duration based on these identified key bacteria.

Result

We observed variations in microbial communities across different age groups, diseases, and infection types. In the elderly group, Pseudomonas aeruginosa exhibited the highest relative abundance, followed by Corynebacterium striatum and Acinetobacter baumannii. Methylobacterium and Prevotella emerged as the dominant genera at the genus level in the younger group, while Mycobacterium tuberculosis and Haemophilus influenzae were prevalent species. Within the bronchiectasis group, dominant bacteria included Pseudomonas aeruginosa, Haemophilus influenzae, and Klebsiella pneumoniae. Significant differences in the presence of Pseudomonas phage JBD93 were noted between the bronchiectasis group and the control group. In the group with concomitant fungal infections, the most abundant genera were Acinetobacter and Pseudomonas, with Acinetobacter baumannii and Pseudomonas aeruginosa as the predominant species. Notable differences were observed in the presence of Human gammaherpesvirus 4, Human betaherpesvirus 5, Candida albicans, Aspergillus oryzae, and Aspergillus fumigatus between the group with concomitant fungal infections and the bacterial group. Machine learning algorithms were utilized to select bacteria and clinical indicators associated with hospitalization duration, confirming the excellent performance of bacteria in predicting hospitalization time.

Conclusion

Our study provided a comprehensive description of the microbial characteristics among patients with lower respiratory tract infections, offering insights from various perspectives. Additionally, we investigated the advanced predictive capability of microbial community features in determining the hospitalization duration of these patients.
Crafting effective oversight for the long-term storage of spent nuclear fuel on sites at risk of climate and coastal hazards
Authors: Brown Alexander , Marlow Jennifer , Sorfleet Julie
Published: May 2024

Despite a documented push to expand nuclear energy in the U.S., the status quo of indefinite in-situ nuclear waste storage is uncertain and increasingly threatened by climate and coastal hazards. Findings from Humboldt Bay, California, one of the nation’s most vulnerable nuclear storage sites, informed recommendations for managing emergent climate and coastal hazards. The existing legislative framework was not designed to address climate and nuclear waste interactions, but more effective oversight leveraging existing federal, state, local, and Tribal government authorities could adapt spent nuclear fuel management to a climate-changed world. More effective oversight requires updated regulations and site-specific risk assessments as well as enhanced coordination across jurisdictions, disciplines, and publics to increase legitimacy, trust, accountability, and creativity in light of failed solutions to a multi-decadal issue.
How does climate change affect the food security and vulnerability of women? A systematic review of gender perspectives
Authors: Moon Monira Parvin
Published: May 2024

In Bangladesh, vulnerable groups including women and food security are severely impacted by climate change. Due to their lack of means for unequal climate adaptation, the impoverished and marginalized in developing countries are more exposed and vulnerable. This research study looks at how Bangladesh’s food security and the status of disadvantaged women are affected by climate change. Gender-based vulnerability is rising as a result of expanding catastrophe consequences, such as decreased agricultural productivity, rising costs, joblessness, food insecurity, post-hazardous illnesses, etc., according to the literature review findings. The assessment highlights the significant risks that climate change poses to Bangladesh’s food security and vulnerable women, including increased susceptibility to food shortages and post-disaster issues, given that women in Bangladesh are more susceptible to these issues due to their social, economic, and political circumstances. The literature review demonstrates that disadvantaged groups, particularly women, are negatively impacted by climate change. Profound policy implications should propose for enhancing system performance, coordinating regional agricultural output, and fortifying resistance to climate change.
Influences of cultural capital and internationalization on global competence in higher education: a systematic literature review
Authors: Teng Yiying , Cosier Meghan E.
Published: May 2024

Introduction

In an increasingly global economy, the global competence of students in higher education is a critical area of importance. The purpose of the study was to explore the research on factors that influence an individual’s global competence in both international and Chinese contexts.

Methods

Under the umbrella of cultural capital theory and Internationalization, a systematic literature review analyzed and synthesized the empirical studies of global competence from 2013 to 2022.

Results

This research revealed that students with higher cultural capital backgrounds obtain more educational opportunities and further exhibit better global competence achievement. Internationalization abroad is a direct and practical pedagogy for global competence acquisition, reflected in student and faculty mobility. Internationalization opportunities in an individual’s home country catalyze global competence.

Conclusion

These results highlight that students who have a lower capital background or few opportunities for mobility can reap the potential benefits of global competence attainment through involvement in domestic educational activities.
The effects of leptin on human cytotrophoblast invasion are gestational age and dose-dependent
Authors: Rumer Kristen K. , Sehgal Shilpi , Kramer Anita , Bogart Kevin P. , Winn Virginia D.
Published: May 2024

Introduction

Leptin and its receptors are expressed by the human placenta throughout gestation, yet the role of leptin in early human placental development is not well characterized. Leptin is overexpressed in the placentas from preeclamptic (PE) pregnancies. PE can result from the impaired invasion of fetal placental cells, cytotrophoblasts (CTBs), into the maternal decidua. We hypothesized that elevated leptin levels would impair human CTB invasion.

Methods

The effects of leptin on the invasion of human CTBs were evaluated in three cell models, HTR-8/SVneo cells, primary CTBs, and placental villous explants using invasion assays. Further, leptin receptor expression was characterized in all three cell models using RT-PCR. Further phosphokinase assays were performed in HTR-8/SVneo cells to determine signaling pathways involved in CTB invasion in response to differential leptin doses.

Results

We found that, prior to 8 weeks gestation, leptin promoted CTB invasion in the explant model. After 11 weeks gestation in explants, primary CTBs and in HTR-8/SVneo cells, leptin promoted invasion at moderate but not at high concentrations. Further, leptin receptor characterization revealed that leptin receptor expression did not vary over gestation, however, STAT, PI3K and MAPK pathways showed different signaling in response to varied leptin doses.

Discussion

These data suggest that the excess placental leptin observed in PE may cause impaired CTB invasion as a second-trimester defect. Leptin’s differential effect on trophoblast invasion may explain the role of hyperleptinemia in preeclampsia pathogenesis.
Validity of stem cell-loaded scaffolds to facilitate endometrial regeneration and restore fertility: a systematic review and meta-analysis
Authors: Huang Qiao-yi , Zheng Hui-da , Shi Qi-yang , Xu Jian-hua
Published: May 2024

Objective

Various stem cell-loaded scaffolds have demonstrated promising endometrial regeneration and fertility restoration. This study aimed to evaluate the efficacy of stem cell-loaded scaffolds in treating uterine injury in animal models.

Methods

The PubMed, Embase, Scopus, and Web of Science databases were systematically searched. Data were extracted and analyzed using Review Manager version 5.4. Improvements in endometrial thickness, endometrial glands, fibrotic area, and number of gestational sacs/implanted embryos were compared after transplantation in the stem cell-loaded scaffolds and scaffold-only group. The standardized mean difference (SMD) and confidence interval (CI) were calculated using forest plots.

Results

Thirteen studies qualified for meta-analysis. Overall, compared to the scaffold groups, stem cell-loaded scaffolds significantly increased endometrial thickness (SMD = 1.99, 95% CI: 1.54 to 2.44, P < 0.00001; I² = 16%) and the number of endometrial glands (SMD = 1.93, 95% CI: 1.45 to 2.41, P < 0.00001; I² = 0). Moreover, stem cell-loaded scaffolds present a prominent effect on improving fibrosis area (SMD = −2.50, 95% CI: –3.07 to –1.93, P < 0.00001; I² = 36%) and fertility (SMD = 3.34, 95% CI: 1.58 to 5.09, P = 0.0002; I² = 83%). Significant heterogeneity among studies was observed, and further subgroup and sensitivity analyses identified the source of heterogeneity. Moreover, stem cell-loaded scaffolds exhibited lower inflammation levels and higher angiogenesis, and cell proliferation after transplantation.

Conclusion

The evidence indicates that stem cell-loaded scaffolds were more effective in promoting endometrial repair and restoring fertility than the scaffold-only groups. The limitations of the small sample sizes should be considered when interpreting the results. Thus, larger animal studies and clinical trials are needed for further investigation.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO, identifier CRD42024493132.
Disease burden of breast cancer and risk factors in Europe 44 countries, 1990-2019: findings of the global burden of disease study 2019
Authors: Yu Shaohong , Cai Xiuli , Wang Xinyu , Lin Xiuquan , Cai Shuanglong
Published: May 2024

Background

Breast cancer (BC) represents a significant health challenge in Europe due to its elevated prevalence and heterogeneity. Despite notable progress in diagnostic and treatment methods, the region continues to grapple with rising BC burdens, with comprehensive investigations into this matter notably lacking. This study explores BC burden and potential contributing risk factors in 44 European countries from 1990 to 2019. The aim is to furnish evidence supporting the development of strategies for managing BC effectively.

Methods

Disease burden estimates related to breast cancer from the Global Burden of Disease 2019(GBD2019) across Eastern, Central, and Western Europe were examined using Joinpoint regression for trends from 1990 to 2019. Linear regression models examined relationships between BC burden and Socio-demographic Index (SDI), healthcare access and quality (HAQ), and BC prevalence. We utilized disability-adjusted life year(DALY) proportions for each risk factor to depict BC risks.

Results

In Europe, the BC burden was 463.2 cases per 100,000 people in 2019, 1.7 times the global burden. BC burden in women was significantly higher and increased with age. Age-standardized mortality and DALY rates of BC in Europe in 2019 decreased by 23.1%(average annual percent change: AAPC -0.92) and 25.9%(AAPC -1.02), respectively, compared to 1990, in line with global trends. From 1990 to 2019, age-standardized DALY declined faster in Western Europe (-34.8%, AAPC -1.49) than in Eastern Europe (-9.4%, AAPC -0.25) and Central Europe (-15.0%, AAPC -0.56). Monaco, Serbia, and Montenegro had the highest BC burden in Europe in 2019. BC burden was negatively correlated with HAQ. In addition, Alcohol use and Tobacco were significant risk factors for DALY. High fasting plasma glucose and obesity were also crucial risk factors that cannot be ignored in DALY.

Conclusion

The burden of BC in Europe remains a significant health challenge, with regional variations despite an overall downward trend. Addressing the burden of BC in different regions of Europe and the increase of DALY caused by different risk factors, targeted prevention measures should be taken, especially the management of alcohol and tobacco should be strengthened, and screening services for BC should be popularized, and medical resources and technology allocation should be optimized.