bluuebunny/crossref_metadata_2025 huggingface dataset:
Continuum de desmontes da saúde pública na crise do covid-19: o neofascismo de Bolsonaro
Authors: Mendes Áquilas , Carnut Leonardo , Melo Mariana
Published: February 2023

Resumo Neste artigo, aprofunda-se a discussão crítica às políticas adotadas pelo governo Bolsonaro em relação à saúde pública, particularmente no que tange ao financiamento em geral, ao enfrentamento da pandemia e ao primeiro ano de implantação do novo modelo de “financiamento” para a Atenção Primária à Saúde (APS). A análise evidencia o acirramento da legitimidade restrita do regime político, assumida por políticas ultraneoliberais e pelo neofascismo do governo Bolsonaro. Estas formas de dominação - política e econômica - engendram uma conjuntura interna que visa remodelar a acumulação de capital na saúde pública via APS por meio de mecanismos “operacionais” burocráticos sutis de desconstrução da universidade do “financiamento”. Na primeira parte, discute-se a abrangência da crise tripla do capital - sanitária, econômica e ecológica - e sua relação orgânica com o Estado no capitalismo dependente brasileiro, abrindo espaço para o crescimento da restrição do regime político endossado pela ascensão do neofascismo. Na segunda parte, aborda-se a escalada do desfinanciamento do Sistema Único de Saúde (SUS) em plena crise de covid-19 e os efeitos da implementação do modelo de financiamento da APS, evidenciando a continuidade do processo de valorização de um “SUS operacional” em detrimento do seu princípio de universalidade como dimensão neofascista do governo Bolsonaro.
HCR-fluorescent in situ hybridization (HCR-FISH) of gemmule-hatched freshwater sponges v1
Authors: Nichols Scott
Published: February 2023

This HCR-FISH protocol using probes and amplifiers from Molecular Instruments is intended for gemmule-hatched freshwater sponges grown in 35 mm coverslip bottom cell-culture dishes with a 10 mm inner-well diameter.
Sidoli Phosphoenrichment From Clean Dry Peptides v1
Authors: Yoo Edwin
Published: February 2023

Sidoli Phosphoenrichment From Clean Dry Peptides
Brainless S-trap Proteomics Protocol Mini Columns or 96 well v1
Authors: Yoo Edwin
Published: February 2023

Brainless S-trap Proteomics Protocol Mini Columns or 96 well
A Talaromyces Fungal Species with Strong Antimicrobial Activity from Deception Island, Antarctica
Authors: Sheau Ting Yong , Lavin Paris Leonardo , González Marcelo Aravena , Wong Clemente Michael Vui Ling
Published: February 2023

Deception Island is well-known for harboring highly diverse microbial communities due to its unique volcanic environment in Antarctica. Most studies focused on bacteria, and relatively little was known about the fungal species on this island. The present study was aimed to determine the antimicrobial production and nutrient utilization profiles of a soil fungus from Deception Island, designated as Im33. Our findings showed that the strain had maximum mycelial growth and sporulation on malt-extract agar (MEA) medium, but it demonstrated the strongest antimicrobial activity in yeast extract-malt extract broth (YMB) medium. Phylogenetic analysis of the internal transcribed spacer 1 and 2 regions showed that it is a species belonging to the genus Talaromyces. It was resistant to cycloheximide concentrations up to 1,000 mg/L and exhibited broad-spectrum antimicrobial activity against Gram-positive and Gram-negative test pathogens, as well as being able to utilize a variety of carbon sources. This is the first report of a Talaromyces species from Deception Island. The capability of the strain to produce broad-spectrum antimicrobial compounds and various enzymes indicated that Antarctic fungi, like their bacterial counterparts, have adopted various adaptation strategies to compete and survive in the extreme environment.
Prediction of the Thermophysical Properties of Papaya Seed Oil Influencing Solvent Selection Based on the New Group Contribution Model
Authors: Alhanif Misbahudin , Kumoro Andri Cahyo , Dyah Hesti Wardhani Dyah Hesti Wardhani
Published: February 2023

As one of the sustainable food sources, papaya seed oil (PSO) has extraordinary health benefits with unsaturated fatty acids being the main components. In general, the PSO extraction can be accomplished by predetermining the thermophysical properties of the PSO, appropriate use of solvent, and operating conditions. However, the thermophysical properties data of the PSO in the literature are quite scarce, while their quantitative measurements are expensive and time-consuming. For this reason, the group contribution models (GCMs) that have been developed over the last few decades can be essential tools for the estimation of the thermophysical properties of PSO. Moreover, this study also proposes a new GCM to predict PSO thermophysical properties based on its fatty acids composition and validate the accuracy using the experimental data available in the literature. The results showed that the new model has excellent accuracy in estimating the thermophysical properties of PSO at 298.15 K and normal boiling point (Tb). The average absolute relative deviation (AARD) for enthalpy of vaporization values at both temperatures were 2.09% and 2.04%, respectively. Meanwhile, the AARD values for molar volume at both temperatures were 0.48% and 0.86%, respectively. Accordingly, the estimated values of the Hansen's solubility parameters and partition coefficients were very close to the experimental data with a distance (D) of 0.21 and AARD of 0.030%. Therefore, this model can be employed to quickly predict the important PSO properties and other its unknown properties based on its molecular structure for its extraction purpose.
Immunophenotyping of Gastritis, Gastric Ulcer and Gastric Cancer using a Cluster of Differentiation (CD) Antibody Microarray
Authors: Hanafiah Alfizah , Sukri Asif , Kosai Nik Ritza , Shuhaili Mohamad Aznan , Mohammed Taher Mustafa , Raja Ali Raja Affendi
Published: February 2023

One of the factors that contribute to the development of gastric cancer is the host immune response. Extensive immunophenotype of gastric cancer can be identified by using antibody microarray technique that profiles more than 100 cluster of differentiation (CD) antigens in parallel. In this study, we used DotScanTM antibody microarray to profile CD antigen expression in patients with distinct digestive diseases for surface antigen disease-signatures. Patients’ blood samples with gastric disorders and healthy controls were taken and processed for leukocytes isolation using Histopaque density gradient centrifugation. Leukocytes were captured onto DotScanTM slides and cell binding densities were analyzed using DotReaderTM. Different groups of gastric diseases were found to be characterized by differentially expressed distinct CD antigens. Compared to normal healthy controls, 17, two and four highly expressed CD antigens were identified in gastritis, gastric ulcer and gastric cancer patients, respectively. The 17 CD antigens that show differential expression in gastritis were CD15, CD16, CD20, CD23, CD24, CD25, CD28, CD34, CD37, CD77, CD102, CD103, CD122, CD128, CD10, CD183, and CD184. High expression of CD64 and CD69 were found in gastric ulcer, whereas CD52, CD126, CD135, and CD121a were highly expressed in gastric cancer. CD antigens involve in T-cell functions had reduced expression in gastric cancer, while proinflammatory cytokines shows increased expression. These results demonstrate specific immunophenotype of CD antigens in patients with various gastric diseases and identification of differential expressed surface antigens may have clinical significance for diagnostic and therapeutic purposes.
A Comparative Study of Anti-Inflammatory Properties and Activities of Green and Red Christia vespertilionis Leaves
Authors: Zambari Izzah Farhah , Muhamad Nur Airina , Abdul Hafid Sitti Rahma
Published: February 2023

Christia vespertilionis is a plant traditionally used to treat various diseases, including inflammation. This study aims to compare and analyze the anti-inflammatory properties and activities of green and red C. vespertilionis leaves and to determine the correlation between the protease inhibition assay and phenolic content. Preliminary phytochemical analysis showed the presence of alkaloids, tannins, saponins, cardenolides, phenolics, cardiac glycosides, flavonoids, and steroids in green and red leaves. Green leaf had the highest anti-inflammation potential, with a high extraction yield (6.39 ± 0.01%), phenolic content (29.25 ± 0.50 mg) gallic acid equivalent [GAE]/mL), flavonoid content (1.57 ± 0.03 mg quercetin acid equivalent [QE]/mL) and tannin content (22.70 ± 3.15 mg tannic acid equivalent [TAE]/mL). Green leaf contained more anti-inflammatory compounds, including n-hexadecanoic acid, phytol, 9, 12, 15-octadecatrienoic acid (Z, Z, Z)- and squalene. The protease inhibition assay showed that green leaf had anti-inflammatory activity at 66.55 ± 2.59% with the half-maximal inhibitory concentration (IC50) of 284.59 ± 10.63 µg/mL. The green leaf showed a significant positive correlation between the protease inhibition assay and phenolic content, with R2 = 0.6821. We conclude that both green and red C. vespertilionis types have the potential to act as anti-inflammatory agents, but green leaves are preferable.
Effect of Dermal Fibroblast Conditioned Medium on Keratinocytes Irrespective of Age Group
Authors: Abdul Ghani Nurul Izzah , Maarof Manira , Roy Chowdhury Shiplu , Saim Aminuddin Bin , Haji Idrus Ruszymah Binti , Mh Busra Fauzi
Published: February 2023

Skin aging causes delayed re-epithelialisation and impaired wound healing. Thus, supplementation of wound healing mediators and extracellular matrix (ECM) components may be a potential treatment strategy for age-related impaired wound healing. Fibroblasts secrete wound-healing factors and can be collected from used medium, i.e., dermal fibroblast conditioned medium (DFCM). In this study, we elucidated the effect of DFCM on the in vitro wound healing of keratinocytes isolated from different age groups (≥18–35, 36–54, ≥55 years) via cell attachment, growth rate, and wound healing rate assays. The DFCM was prepared by culturing confluent fibroblasts with serum-free keratinocyte-specific (DFCM-KM) and fibroblast-specific (DFCM-FM) medium. The cell attachment efficiency decreased with the increase of age. However, keratinocyte attachment was enhanced in the DFCM-KM group, where it was 1.24, 1.27, and 1.32 times higher of cells concentration for the ≥18–35-, 36–54-, and ≥55-year age groups, respectively, as compared to the control group. The keratinocytes from each age group demonstrated a similar growth profile for all culture conditions, where the DFCM-KM group exhibited a comparable growth rate with the control group whilst the DFCM-FM group exhibited a significantly lower growth rate compared to the other groups. In contrast, the DFCM-FM group demonstrated a significantly higher healing rate in all age groups as compared to the DFCM-KM and control groups. However, there was no significant difference between the healing rates of the DFCM-KM and control groups. In conclusion, DFCM-KM enhanced keratinocyte attachment while DFCM-FM enhanced the keratinocyte healing rate irrespective of donor age, which indicated the potential application of DFCM in wound healing in aged skin.
Legal regimes of entrepreneurial activity in the securities market and the collective investments market
Authors: Shevchenko O. M.
Published: February 2023

The article substantiates that entrepreneurial activity in the securities market and in the collective investment market has one special legal regime. The author identifies the general legal means used to regulate all types of professional activity in this area. The combination of licensing with mandatory membership in SRO is a specific approach for regulating entrepreneurial activity in the securities market and collective investments. At the same time, regulation of certain types of activities in these markets has certain features. Investment advisors have a simplified legal regime of activity. Exclusive activity regimes have been established for forex dealers, non-state pension funds and joint-stock investment funds. The necessity to unify the forms, procedure and deadlines for reporting of professional participants of the securities market and professional participants of the collective investment market is justified, due to the common regulatory objectives and similarity of indicators of such reporting. The author makes a proposal to introduce a special term — “professional participant in the collective investment market” to designate management companies, specialized depositories, non-state pension funds and joint-stock investment funds. It is concluded that in the future, the sanctions regime on the securities market and collective investments will cease to be extraordinary.
Convertible loan as a mechanism for startup development
Authors: Sushkova O. V.
Published: February 2023

The development of digital technologies, electronic interaction in small innovative enterprises has led to the emergence of new contractual typologies based on economic efficiency that meet the needs of business and professional entities through not only the exchange of information, but also a special financing procedure. The mechanism of «convertible loan» is the tool that allows startups at the initial stage of their activities to provide it in the future. This allows not only to technologically increase the role of the results of intellectual activity, developed and introduced into production, but, in general, the technical potential of the country.
Digital technologies in the business of law firms as a source of ideas for student projects implemented as part of the startup as a graduation program
Authors: Trofimova E. V.
Published: February 2023

The success of the “Startup as a WRC” program is largely due to the effectiveness of combining the efforts of students and business representatives in the development and implementation of innovative technological projects. The prerequisite for such interaction in the field of LegalTech is the close study by law students of promising areas of digitalization of legal business. An overview of digital technologies that allow law firms to more effectively organize interaction with the client and improve the quality of services provided is presented. The conditions necessary for the functioning of a virtual law firm are listed, the main directions of automation of business processes of law firms are outlined, and the prospects for the use of artificial intelligence in legal practice are shown. The results of the study can be used by students when choosing business ideas for the implementation of startups in the field of LegalTech.
Compliance and state control: two models for ensuring compliance with the law by business entities
Authors: Kuznetsova N. V.
Published: February 2023

The article discusses the features of state control and compliance as two models for ensuring compliance by business entities with mandatory requirements established by law. The concept, goals, subject, foundations of the organization and other aspects of state control and compliance are disclosed. Comparative characteristics of both models of control allows us to conclude that it is possible to use the basic provisions developed in the legislation on state control as a guideline for the development of standard documentation regulating compliance, as well as local acts of corporate organizations related to internal control.
Legal regime of non-monetaty claims against the debtor arising from contracts concluded before the initiation of bankruptcy proceedings
Authors: Kantor N. E.
Published: February 2023

The successful development of the economy of the Russian Federation implies the stability of civil turnover, proper fulfillment by counterparties of their obligations. The rupture of economic chains leads to an avalanchelike bankruptcy of economic entities, deterioration of the investment climate in the country. The article analyzes the issue of the possibility of a legal entity (debtor), in respect of which a bankruptcy case has been initiated, fulfilling property (non-monetary) obligations in favor of counterparties under contracts concluded before the initiation of bankruptcy proceedings against the debtor. Such execution may create preferential satisfaction of the claims of individual creditors over others with whom there are also contracts not executed by the debtor. Justified that property grants from the debtor can meet the goals of restoring the debtor’s solvency, replenishing the bankruptcy estate in the interests of all creditors, and therefore creditors’ claims for the performance of property obligations in kind should be subject to judicial protection and enforcement throughout the period of the insolvent debtor’s economic activity.
The notion and the legal nature of the sanctions regime of economic activity
Authors: Ryazanova A. R.
Published: February 2023

Currently economic activities are complicated by the application of numerous and constantly changing foreign and Russian restrictive measures (sanctions). In this article the author presents the concept of formation of the sanction’s regime of economic activity and on the basis of the analysis of doctrinal approaches to the definition of the concepts of “sanctions” and “legal regime” offers a definition of the sanctions regime of economic activity. As a result of the conducted study of the doctrinal classification of legal regimes by the criterion of legal properties into ordinary and extraordinary, the author presented a justification for attributing the sanctions regime of economic activity to the extraordinary legal regimes on the basis of six qualifying characteristics is presented. The author draws a conclusion about the need for further study of the sanctions regime as a system formation with a special structure, constituent elements and content.
Análisis de componentes y valoración del paisaje: Parque Nacional Llanganates. Píllaro. Ecuador
Authors: Miranda Paredes Linda Elizabeth , Velastegui Moreno Lenin Alexis , Álvarez Miranda Gabriela Elizabeth
Published: February 2023

El Ecuador, país latinoamericano privilegiado y reconocido por sus abundantes recursos naturales y su rico patrimonio cultural, ubicados en las cuatro regiones naturales: Costa, Sierra, Oriente y la Región Insular. En este sentido, de acuerdo al Ministerio de Ambiente, once territorios cumplieron con los requisitos para alcanzar la denominación de Parques Nacionales; Llanganates fue incorporado en 1996. El objetivo del presente trabajo fue el análisis paisajístico mediante el levantamiento de los elementos naturales, antrópicos y culturales del Parque Nacional Llanganates; la metodología aplicada se basó en un modelo multidisciplinar, a través de la investigación de tipo exploratorio, descriptivo y explicativo, el enfoque cualitativo vinculado con la valoración de componentes paisajísticos. Además, los recursos intangibles constituidas por ricas leyendas surgidas con la conquista española, como la captura y asesinato en Cajamarca del Inca Atahualpa, trasladado a Quito, y posteriormente enterrado de acuerdo con expertos historiadores y antropólogos, en la Hacienda Malqui Machay, Sigchos, provincia de Cotopaxi, un lugar rico en ruinas y múltiples vestigios incas. Así también se relata que Rumiñahui medio hermano y general del Inca, trasladó los tesoros y los ocultó en Llanganates, lo que despertó curiosidad y expectativa. Finalmente, los resultados obtenidos en el levantamiento de los componentes Biofísicos, visuales y antrópicos a más del legado cultural son importantes para exponer los grandes valores paisajísticos del sitio de estudio. Concluyendo, el conocimiento y puesta en valor de lugares icónicos abrieron una percepción más amplia sobre el mítico Parque Nacional de los Llanganates.
Eco+Pedagogía de pensamiento en diseño de la arquitectura del paisaje rural Caribe en Piojó
Authors: Perea Restrepo Sergio Antonio , Manrique Niño María Ximena
Published: February 2023

El planteamiento de una didáctica de aprendizaje activo de enfoque ecológico, aplicada en el Programa de Arquitectura de la Corporación Universidad de la Costa, experimentada por estudiantes en las asignaturas electivas de profundización en Gestión Territorial y Diseño e Innovación, en el marco del programa institucional RETOS/UNICOSTA 2021, es una experiencia que expone la metodología de pensamiento en diseño, aplicada en la investigación “Arquitectura de la Vivienda Rural en el Paisaje Caribe Colombiano”; el principal resultado del proceso ha sido la empatización y planeación participativa con la comunidad del corregimiento de Aguas Vivas, en el Departamento del Atlántico (Colombia), con la cual el equipo de estudio logro generar vínculos de colaboración en función del reto académico. La didáctica de aprendizaje y su enfoque de investigación proyectual en arquitectura, es una alternativa pedagógica en la formación de competencias disciplinares en la sostenibilidad de la arquitectura del paisaje rural local.
Mampostería confinada vs pórticos de hormigón:
Authors: Franco Rojas Yadila , González Díaz Liliana , Milanés Batista Celene , Félix López Nelson Saint , Calderín Mestre Francisco
Published: February 2023

El 60 % de las viviendas en Santiago de Cuba se ejecutan por medios propios. Prevalecen las estructuras con pórticos de hormigón armado donde se violan requerimientos del diseño sismorresistente, incrementándose la vulnerabilidad sísmica del territorio. En esta investigación se evaluó el sistema estructural de muros portantes de mampostería confinada, poco utilizado en Cuba; el que además de posibilitar el empleo de materiales locales a disposición de la población, puede proveer un adecuado comportamiento ante la acción sísmica. Como resultados, se compararon dos variantes de viviendas diseñadas con estructuras de pórticos de hormigón armado y muros portantes de mampostería confinada, empleando la norma cubana NC: 207, 2019 y la norma mexicana NTCM, 2020, respectivamente. Como conclusión, se demuestra que, aunque ambas variantes garantizan un comportamiento sísmico adecuado, en la estructura de muros portantes de mampostería confinada se reducen los costos en un 46%, evidenciando su factibilidad técnica y económica.
THE FLYPAPER EFFECT PHENOMENON OF INTERGOVERNMENTAL TRANSFERS DURING THE COVID-19: EVIDENCE FROM INDONESIA
Authors: Wati Lela Nurlaela , Ispriyahadi Heri , Zakaria Dhika Habibi
Published: February 2023

This study aims to confirm the flypaper effect phenomenon and the impact of the Covid-19 pandemic on local own-source revenue (LOR), general allocation fund (GAF), and local government financing on local government expenditure in Indonesia. The research used a quantitative method, while the sample was data on regional government budget (RGB) realization in 335 local governments in 2019 – 2020. The data were analyzed using Moderating Regression Analysis. The study found that there was a flypaper effect phenomenon that encouraged the local governments to use GAF, instead of LOR for their local expenditure. The GAF and local government expenditures were higher during the Covid-19 period. To overcome the flypaper effect phenomenon, the central government is advised to improve the GAF policy by setting priorities for its use. Local governments must encourage micro, small, and medium enterprises to help support LOR. This study proves there exists the phenomenon of the flypaper effect in developing countries that implement the presidential system (republic) and provide substantial empirical evidence on government spending policies during crisis and non-crisis (Covid-19).
THE IMPACT OF ICT CAPITAL GROWTH ON ECONOMIC GROWTH: THE CASE OF EGYPT
Authors: Mansour Hoda
Published: February 2023

Capital investments in information and communication technology (ICT) have been a major contributor to the growth of several developed countries. In an attempt to boost their economies, some emerging and developing countries have been following a similar path, in which they heavily invest in the sector of ICT. However, due to other factors, ICT capital growth may not always produce the desired economic outcome. The purpose of this study is to estimate the impact of capital growth in ICT on economic growth in one developing country, Egypt, which has been heavily investing in the sector of ICT. The study analyses time series data covering the period from 1999 to 2019 using an error correction model. The findings demonstrate that there is no long-term positive association between ICT capital growth and economic growth in Egypt. While the development of ICT provides the potential for Egypt to achieve sustained economic growth, the significance and size of these impacts are currently negligible. The study concludes that in order to benefit from capital investments in ICT, policymakers should enact high-quality investment policies and improve the overall quality of the surrounding environment, such as the regulatory and institutional environments, in addition to controlling inflation and government consumption
Role of personality traits in shaping entrepreneurial intention: Comparative study of South Korea and Vietnam
Authors: Nguyen Phuong Mai , Luu Thi-Minh-Ngoc , Vo Nam D. , Nguyen Phuc Nguyen
Published: February 2023

This paper investigates the role of personality traits in nurturing entrepreneurial intention in South Korea and Vietnam. We developed a research model to examine the integrated influence of both positive entrepreneurial characteristics and dark triad on entrepreneurial intention in South Korea and Vietnam. Primary data was collected from 550 students in South Korea and 700 students in Vietnam using the convenient sampling method in a self-administered questionnaire survey. We used structural equation modelling (SEM) to analyse structural relationships between positive entrepreneurial attributes, dark triads, and entrepreneurial intention in two samples. T-tests were also performed to explore any differences in students’ entrepreneurial intention in South Korea and Vietnam regarding their family background and gender. Findings showed that positive entrepreneurial attributes and dark triads influence entrepreneurial intention differently in the two countries. While the dark triad mainly influenced Vietnamese students’ intention to startup, Korean students received more impact from the positive entrepreneurial characteristics such as risk tolerance, locus of control, and entrepreneurial alertness. Surprisingly, both gender and family tradition do not affect students’ entrepreneurial intention. Based on our findings, we suggested that policymakers and higher education institutions in both South Korea and Vietnam promote students’ entrepreneurial intentions in the future.
EMERGING EQUITY MARKET REACTION TO PANDEMIC PREVENTION POLICY: EVIDENCE FROM REGRESSION DISCONTINUITY DESIGN
Authors: Aktan Bora
Published: February 2023

The purpose of this study is both to release the effects of the current pandemic on emerging equity markets and to examine the efficacy of the prevention policy to lessen the plausible negative effects. In this context, Turkey, as an emerging market, is examined by adopting the Regression Discontinuity Design which is a robust non-experimental approach for evaluating the causal effects of interventions. The results of the research reveal that the COVID-19 pandemic is effective in Bourse Istanbul after a certain period when it first appeared in the world. And therewithal, the efficiency of preventing policy taken in the country statistically decreased the negative impact of the pandemic.
Evaluation of pre- and post-transplant electroencephalographic examination in hematopoietic stem cell transplant patients
Authors: Yavlal Figen , Doğan Güngen Belma , Güzey Aras Yeşim , Çelik Yusuf
Published: February 2023

Background and purpose – Haematopoietic stem cell transplantation (HSCT) is one of the most effective treatment methods for many malignant and non-malignant diseases. In this study, we aimed to detect electroencephalographic (EEG) anomalies at an early stage in patients who underwent allogeneic and autologous HSCT and required the management of potentially lifethreatening non-convulsive seizures. Methods – The study was conducted with 53 patients. The age, gender, HSCT type (allogeneic or autologous), and treatment regimens applied before and after HSCT were recorded. All patients underwent EEG monitoring twice, once on the first day of hospitalization and again one week after conditioning regimens began and HSCT was performed. Results – When the pre-transplant EEG findings were examined, 34 (64.2%) patients had normal EEGs and 19 (35.8%) had abnormal EEGs. After transplantation, 27 (50.9%) had normal EEG findings, 16 (30.2%) had a basic activity disorder, 6 (11.3%) had a focal anomaly, and 4 (7.5%) had a generalised anomaly. In the allogeneic group, the anomaly rate in post-transplant EEGs was significantly higher than that in the autologous group (p<0.05). Conclusion – It is important to consider the likelihood of epileptic seizures in the clinical follow-up of HSCT patients. EEG monitoring is crucial for the early diagnosis and treatment of such non-convulsive clinical manifestations.
Isolated IgG4 hypertrophic pachymeningitis with cranial nerve involvement
Authors: Faragó Péter , Kincses Zsigmond Tamás , Kovács László , Hortobágyi Tibor , Despotov Katalin , Radics Bence , Klivényi Péter , Tajti János
Published: February 2023

IgG4-related (IgG4-RD) disease is a relatively newly identified, chronic autoimmune disorder that can affect any organ system. The disease is relatively rare. It has mostly systemic presentation, however it can also appear in isolated form in one single organ. In our report, we demonstrate an elderly male patient’s case with IgG4-RD presented in the form of diffuse meningeal inflammation and hypertrophic pachymeningitis with one-sided cranial nerve and intraventricular involvement.
Simulation modeling of the activity of the duty unit of the territorial body of the Ministry of the Interior of Russia at the district level
Authors: Самданов Г.Б.
Published: February 2023

Рассматривается деятельность дежурной части территориального органа МВД России на районном уровне как системы массового обслуживания с применением методов имитационного моделирования. Приведена имитационная модель, основные показатели, характеризующие работу дежурной части территориального органа МВД России с точки зрения теории массового обслуживания. Показан пример расчета основных характеристик типовой дежурной части территориального органа МВД России, проведен оптимизационный эксперимент с моделью. Модель позволяет осуществить анализ и прогноз работы дежурной части территориального органа МВД России, проигрывать различные сценарии при изменении основных параметров дежурной части. Материалы статьи представляют практическую ценность в информационно-аналитической деятельности органов внутренних дел Российской Федерации в целях оценки работы дежурной части территориального органа МВД России.

This article examines the activities of the duty unit of the territorial body of the Ministry of the Interior of Russia at the district level as a queuing system using simulation modeling methods. The simulation model, the main indicators characterizing the work of the duty unit of the territorial body of the Ministry of the Interior of Russia from the point of view of the theory of queuing are given. An example of calculating the main characteristics of a typical duty unit of the territorial body of the Ministry of the Interior of Russia at the district level is shown, an optimization experiment with the model is carried out. The model allows you to analyze and forecast the work of the duty unit of the territorial body of the Ministry of the Interior of Russia, to play various scenarios when changing the main parameters of the duty unit. The materials of the article are of practical value in the information and analytical activities of the internal affairs bodies of the Russian Federation in order to assess the quality of the work of the duty unit of the territorial body of the Ministry of the Interior of Russia.
On some approaches to machine learning of convolutional neural networks in the tasks of processing aerial images of various presentation formats
Authors: Дзвинко Р.В.
Published: February 2023

В представленной научной работе приведен один из подходов к решению задачи распознавания образов на массиве исходных данных аэрофотоснимков различного разрешения и форматов представления. На основе критического анализа существующего инструментария был выбран механизм сверточных нейронных сетей для решения задач классификации, детектирования, сегментации и анализа произошедших изменений с малой дискретностью изменений. Автором работы предложена программная реализация выбранного способа распознавания, в том числе с решением задач моделирования объектов реального мира на картографической основе.

The presented scientific paper presents one of the approaches to solving the problem of pattern recognition on an array of initial data of aerial photographs of various resolutions and presentation formats. Based on a critical analysis of the existing tools, a convolutional neural network mechanism was chosen to solve the problems of classification, detection, segmentation and analysis of changes with a small discreteness of changes. The author of the paper proposed a software implementation of the selected recognition method, including solving problems of modeling real-world objects on a cartographic basis.
Presentation of knowledge about the expansion of intelligent technologies of soft architectures of biometric systems in the training of IT specialists
Authors: Птицына Л.К. , Струев А.М. , Эль Сабаяр Шевченко Н. , Золкин А.Л.
Published: February 2023

Представлено целеполагание цифровой экономики. Обоснована востребованность формирования индивидуальных образовательных траекторий при подготовке ИТ-специалистов. Показана значимость интегрированных систем формализаций в формировании компетенций цифровой экономики. Описаны причины важности обеспечения информационной безопасности. Рассмотрены особенности использования интеллектуальных агентных технологий при обеспечении информационной безопасности. Описаны современные тенденции развития исследований агентных технологий по профилю защиты информации. Раскрыты характерные приемы интеграции формализаций на примере анализа влияния агентов на качество функционирования комплексных систем защиты информации. Определен математический аппарат интеграции формализаций.

The goal-setting of the digital economy is presented. The demand for the formation of individual educational trajectories in the preparation of IT specialists is substantiated. The importance of integrated systems of formalizations in the formation of competencies of the digital economy is shown. The reasons for the importance of ensuring information security are described. The features of the use of intelligent agent technologies in ensuring information security are considered. The current trends in the development of research on agent technologies in the field of information security are described. The characteristic methods of integration of formalizations are revealed on the example of the analysis of the influence of agents on the quality of functioning of complex information security systems. The mathematical apparatus of integration of formalizations is defined.
The method of assessing the quality of functioning of the adaptive information security system
Authors: Швецов А.С. , Терехов В.Г. , Соколовский А.Н.
Published: February 2023

Рассматриваются вопросы качества функционирования систем адаптивного управления процессами защиты информации в автоматизированных системах управления при деструктивных информационных воздействиях. Предложен метод оценивания функционирования адаптивной системы защиты информации, который заключается в использовании комплексного многокритериального подхода для одновременного оценивания как статической, так и динамической составляющих рассматриваемой системы. Для динамической составляющей определены критерии оценивания, события, возникающие в процессе адаптации, и показатель защищенности, представляющий собой вероятность неотклонения активного профиля защиты от состояния, которое является результатом правильной конфигурации защиты и эффективной реализации алгоритма выбора активного профиля защиты.

The issues of assessing the quality of functioning of information security systems and adaptive control of information security processes in automated control systems during destructive information impacts are considered. A method for evaluating the quality of functioning of an adaptive information security system is proposed, which consists in using an integrated multi-criteria approach for the simultaneous evaluation of both the static and dynamic components of the information security system under consideration. For the dynamic component, evaluation criteria are defined, events that occur during the adaptation process and a security indicator, which is the probability that the active protection profile does not deviate from the state that is the result of the correct configuration of protection profiles and the effective implementation of the active selection algorithm.
Neuro-fuzzy systems in modeling devices of unmanned vehicles
Authors: Золкин А.Л. , Айгумов Т.Г. , Тормозов В.С. , Василенко К.А.
Published: February 2023

Рассматривается роль и значение адаптивных нейронечетких систем и теории нечетких множеств, метод определения истинности правил, показана итерационная особенность исследуемого алгоритма. В настоящее время экспертные системы на основе нечетких правил применяются в автомобильной, аэрокосмической и транспортной промышленности, в области изделий бытовой техники, сфере финансов, анализа и принятия управленческих решений и др. Приводится практическая реализация расчета функции слоя фаззификации и функциональное значение математического аппарата сети. Акцентируется значение использованного персептрона в создании аппарата нечеткого вывода в цифровых и аналоговых актуаторах. Нечеткие системы, широко применяемые для понимания поведения системы, очень интерпретируемы и способны моделировать человеческие знания с помощью понятных лингвистических терминов. Предлагается модель практического использования алгоритма при моделировании работы устройства в беспилотном транспортном средстве.

The article discusses the role and importance of adaptive neuro-fuzzy systems and fuzzy set theory. The method of determining the truth of the rules is considered, the iterative feature of the algorithm under study is emphasized. Currently, expert systems based on fuzzy rules are used in the automotive, aerospace and transport industries, in the field of household appliances, in finance, analysis and management decision-making, and many others. A practical implementation of the calculation of the function of the fuzzification layer and the functional significance of the mathematical apparatus of the network are given. The importance of the used perceptron in the creation of a fuzzy inference apparatus in digital and analog actuators is emphasized. Fuzzy systems, widely used to understand system behavior, are highly interpretable and able to model human knowledge in understandable linguistic terms. A model for the practical use of the algorithm in simulating the operation of a device in an unmanned vehicle is proposed.
Identification of prospecting term-like phrases and extraction of their meanings based on the analysis of biomedical scientific publications
Authors: Золотарев О.В. , Хакимова А.Х. , Зацман И.М. , Гу Д.
Published: February 2023

Представлены результаты автоматизированной обработки научных публикаций с целью поиска и выделения в них терминоподобных словосочетаний и извлечения их значений, определяемых контекстом. Показано, что в биомедицинских публикациях словосочетания, включающие традиционные термины, приобретают новые значения, что свидетельствует об эволюции научного знания. Например, в биомедицине появление новых значений словосочетаний, включающих термин cluster, иллюстрирует эволюцию знания. При этом может происходить становление устойчивых многословных терминов.

The article presents the results of automated processing of scientific publications to search for and highlight term-like phrases in them and extract their meanings determined by contexts. It is shown that in biomedical publications phrases that include traditional terms acquire new meanings, which indicates the evolution of scientific knowledge. For example, in biomedicine, the emergence of new meanings for phrases that include the term “cluster” illustrates the evolution of knowledge. In this case, the formation of stable verbose terms can occur.
Predicting pumping station failures using unsupervised machine learning
Authors: Канарский В.А.
Published: February 2023

Машинное обучение лежит в основе многих инновационных технологий искусственного интеллекта. Внедрение программ на основе машинного обучения в производство позволяет предсказывать поломки промышленного оборудования, предотвращая огромные расходы на оперативное техническое обслуживание. На основе временных данных датчиков насосной станции исследована эффективность различных алгоритмов машинного обучения без учителя на базе библиотеки ScikitLearn Python.

Machine learning is at the heart of many innovative artificial intelligence technologies. Implementation of machine learning-based programs in production allows predicting breakdowns of industrial equipment, thus preventing huge operational maintenance costs. Based on temporal data from pumping station sensors, the effectiveness of various teacherless machine learning algorithms based on the ScikitLearn Python library is investigated.
Methodological bases for assessing the quality of services of organizations of higher education in Russia
Authors: Клунко Н.С. , Сливин Т.С.
Published: February 2023

Предложен подход к решению вопросов, связанных с оценкой качества образовательных услуг, оказываемых вузами России. Целью данной статьи является разработка методического подхода, позволяющего оценить качество образовательных услуг вузов России с учетом всего многообразия факторов, воздействующих на данный элемент современной образовательной системы. Обосновывается положение относительно того, что в процессе оценивания целесообразно использовать количественные и качественные методы оценки. Применять их следует в комплексе, а полученные результаты целесообразно дополнять инструментами маркетингового анализа, которые позволяют рассмотреть проблему качества образовательных услуг под углом зрения существования вуза в маркетинговой среде. Предложенный подход призван определить силу воздействия различных факторов образовательной среды на качество образовательных услуг, имея в виду количественные оценки влияния сильных и слабых сторон на использование возможностей и защиту от угроз, формирующихся в маркетинговой среде современного российского вуза.

In the study, the author proposes an approach to solving issues related to assessing the quality of educational services provided by Russian universities, the purpose of this article is to develop a methodological approach that allows assessing the quality of educational services of Russian universities, considering the whole variety of factors affecting this element of the modern educational system. The paper substantiates the position that in the evaluation process it is advisable to use quantitative and qualitative assessment methods, they should be used in combination, and it is advisable to supplement the results obtained with marketing analysis tools that allow us to consider the problem of the quality of educational services from the point of view of the existence of a university in a marketing environment. The proposed approach allows us to determine the strength of the impact of various factors of the educational environment on the quality of educational services, bearing in mind quantitative assessments of the influence of strengths and weaknesses on the use of opportunities and protection against threats that are emerging in the marketing environment of a modern Russian university.
The importance of surface tension in endodontic irrigation: A review study
Authors: Mansoorkhani Hamidreza Abdollahi , Mahmoudi Farshid
Published: February 2023

The surface tension of irrigants determines their ability to penetrate dentinal tubules and access the apical third of root canals. It is defined as an affinity for a liquid's surface area to decline in the case of surface tension between molecules. Irrigating the canal wall is vital for dissolving organic tissues and disinfecting dentin and its tubules in root canal preparation. Even with super elastic rotary preparation, untouched spaces are a typical issue during root canal instrumentation. As a result, the antimicrobial activity and solvent action in these areas is essential to the disinfection of root canals. The ability to diagnose irrigants quickly and treat them successfully depends on a thorough discernment of their surface tension. In this study, surface tension involved in endodontic solutions was examined for etiological factors, features, and possible consequences. The relevant studies were found by searching online databases. We identified 30 articles using the hand search method and summarized the critical factors of each study. It was found that low surface tension agents would penetrate tubules more acceptable and that surface tensions estimated at various temperatures and concentrations affected canal cleaning.
Early childhood caries- Etiology, prevention and management: A Review
Authors: Dutta Sharbari , Mohapatra Abinash
Published: February 2023

Early Childhood Caries (ECC) is a severe debilitating disease affecting the primary dentition of young children in both developing and industrialized countries. Historically, the management of ECC has a global scenario showing operative management of the disease. The contemporary method of preventing the carious process mainly focuses on dietary factors, host factors and removal of plaque biofilm. Enamel demineralization is caused by acidogenic and aciduric bacteria. Colonization of microorganisms in the mouth of children can occur via horizontal or vertical transmission or both. The bacteria present in dental plaque metabolize sugars and starches to produce acids, which lowers the pH in the mouth and promotes loss of minerals from the tooth surface. Sucrose is the most common sugar and when metabolized, produces dextrans which promote superior bacterial adhesion to teeth. Visible plaque on the labial surfaces of the maxillary incisors were strongly associated with the caries development. Saliva buffers plaque acids, aids in oral clearance and acts as a reservoir for minerals to assist in the mineralization of enamel. Most studies have put forward a correlation between bed time use of bottles with sweetened contents especially lactose. One of the factors included by Newbrun in factors causing dental caries is time. The CPP-ACP complex, an effective remineralizing complex preventing the acidic environment reduce incidence of caries. Conventional probiotics comprised of lactobacilli and bifidobacterium which were mainly of intestinal origin; the contemporary probiotic research has brought forward that oral diseases like dental caries, periodontal problems and candida infections have direct link with oral microbial disequilibria. A promising new approach towards primary prevention of the disease is to target the infectious component of Early Childhood Caries by preventing or delaying acquisition of Streptococcus mutans at an early age.