bluuebunny/crossref_metadata_2025 huggingface dataset:
Scientific Literacy Competency Profile of Junior High School Students on Sustainable Energy
Authors: Himmah Rif'atul , Jatmiko Budi , Prahani* Binar Kurnia , Saphira Hanandita Veda
Published: December 2024

The increasing demand for sustainable energy solutions presents a critical challenge that necessitates the development of scientific literacy among students. In response to this challenge, it is essential to develop students' understanding of sustainable energy. This study aims to analyze the science literacy profile of junior high school students on sustainable energy materials. A descriptive quantitative study was carried out in August 2024 at a State Junior High School in Kediri Regency, East Java, Indonesia with a sample of 130 grade VIII students. The research instrument was validated literacy test categorized as highly valid, with a reliability score of 92.14%, encompassing three PISA science competencies. The results showed that the majority of students from the sample had science literacy at the basic level or it can be said that it is in the low category with an average score of 49.00, where Students can only search for information in the science texts presented. The science literacy profile in the three competencies was also low, with an average score of 45.50% to explain scientific phenomena, 35.40% to design and evaluate research and interpret data, and 40.00% to research, evaluate, and use scientific information in decision-making. In conclusion, the science literacy of junior high school students is relatively low in all aspects tested, indicating the need for improvement in science learning, especially on the topic of sustainable energy
POLA LUKA PADA ANAK KORBAN KEKERASAN FISIK YANG DIPERIKSA DI RSUP PROF. DR. I.G.N.G. NGOERAH PADA JANUARI 2020-AGUSTUS 2022
Authors: Indriyani Ni Putu Ayu , Yulianti Kunthi , Rustyadi Dudut , Henky .
Published: December 2024

Latar Belakang: Kekerasan pada anak di Indonesia setiap tahun mengalami peningkatan secara signifikan. Adanya pola luka pada kasus kekerasan fisik pada usia anak (0-18 tahun) dapat membantu mendeteksi dan identifikasi kejadian kekerasan yang dialami oleh seorang anak. Metode: Penelitian ini merupakan penelitian case series dengan penyajian secara dekskriptif, dengan metode pengambilan data sekunder yaitu rekam medis pasien anak yang mengalami kekerasan fisik yang diperiksa di RSUP Prof. dr. I.G.N.G. Ngoerah dengan rentang waktu bulan Januari tahun 2020 sampai bulan Agustus tahun 2022. Hasil: Kekerasan fisik pada anak mayoritas dilakukan oleh seseorang yang tidak dikenal (84,6%). Kekerasan fisik terhadap anak terbanyak dialami oleh laki-laki (92%). Kejadian kasus tertinggi ditemukan pada rentang usia 13-18 tahun (69%). Jenis luka yang paling banyak ditemukan yaitu vulnus excoriatum dan hematoma (40%) sedangkan lokasi luka yang memiliki frekuensi tertinggi yaitu regio capitis (53%). Simpulan: Terdapat pola luka yang khas pada anak korban kekerasan fisik.
Kata kunci :  Pola luka, Kekerasan Fisik, Anak
Identification of Blastocystis Hominis: Relationship with IL-6 Levels Colorectal Cancer Patients
Authors: Amsal Mochammad Fariz , Irawati Nuzulia
Published: December 2024

Blastocystis hominis adalah protozoa yang umum ditemukan dalam feses manusia, Blastocystis hominis memiliki distribusi yang luas di seluruh dunia. Penelitian ini bertujuan untuk menganalisis keterkaitan keberadaan blastocystis hominis dengan kadar interleukin-6 pada pasien kanker kolorektal. Penelitian ini menggunakan metode observasi analitik dengan desain cross sectional. Sampel yang digunakan sebanyak 32 pasien kanker kolorektal di RSUP Dr. M. Djamil kota Padang. Berdasarkan temuan diperoleh rerata kadar interleukin 6 pada kelompok pasien kanker kolorektal yang positif Blastocystis hominis lebih rendah dibandingkan dengan yang negatif Blastocystis hominis yaitu 47,8 pg/mL pada positif dan 50,5 pg/mL. Tidak terdapat keterkaitan Blastocystis hominis dengan kadar IL-6 pada pasien kanker kolorektal..
THE INFLUENCE OF MENTAL HEALTH DISORDERS ON THE STUDENT COMPETENCY TEST FOR MEDICAL PROFESSIONAL PROGRAM (UKMPPD) RESULTS AT UDAYANA UNIVERSITY
Authors: Ganesha I Gde Haryo , Sundariyati I Gusti Ayu Harry , Gifensius Julyvia , Tjandra David Christopher , Dewayani Ida Ayu Putu
Published: December 2024

Pendidikan kedokteran merupakan jurusan akademik yang sangat diminati dan ditargetkan oleh banyak kalangan. Namun, dalam proses pembelajarannya, seorang mahasiswa kedokteran harus menghadapi berbagai tuntutan akademik yang berat dan dapat menyebabkan kesehatan mentalnya terganggu. Gangguan kesehatan mental merupakan kondisi seseorang mengalami gangguan psikologis sehingga menyebabkan perubahan negatif pada kesejahteraan hidup, fisiologis kejiwaan, dan kecakapan hidup. Beberapa contoh gangguan ini adalah perasaan stres, cemas, dan depresi. Stres merupakan reaksi tertekan pada tubuh terhadap besarnya tuntutan dan kewajiban yang harus dilakukan dalam waktu tertentu. Cemas adalah kondisi seseorang yang merasa gelisah, takut, dan khawatir yang terlalu berlebihan terhadap masa depan. Depresi merupakan kondisi berkurangnya energi tubuh, berkurangnya minat dalam menjalankan aktivitas sehari-hari, serta perasaan sedih yang berkepanjangan. Segala stresor yang menyebabkan gangguan kesehatan mental ini tidak hanya didapatkan dari proses pembelajaran, namun juga didapatkan dari kondisi eksternal, seperti tekanan dari teman sejawat, finansial, dan keluarga. Gangguan kesehatan mental mampu memberikan pengaruh besar bagi mahasiswa kedokteran dalam melaksanakan aktivitas perkuliahannya, salah satunya adalah pengaruhnya terhadap hasil Uji Kompetensi Mahasiswa Program Profesi Dokter (UKMPPD). UKMPPD merupakan exit exam nasional bagi mahasiswa program profesi dokter yang harus diambil sebelum mengangkat sumpah dokter, ujian ini terdiri atas Multiple Choice Questions (MCQ) dan Objective Structured Clinical Examination (OSCE). Kondisi mental yang tidak sehat berpengaruh pada kinerja mahasiswa dalam menganalisis setiap materi yang akan dipelajari. Besarnya beban mental yang ditampung mahasiswa akan membuat diri mereka tidak fokus untuk mempelajari materi secara terstruktur sehingga tidak semua materi dapat dipelajari dengan baik. Hal ini bermuara pada hasil UKMPPD yang tidak optimal.
Artificial Intelligence: A New Reality To Promote Inclusion In Higher Education
Authors: Salazar Pedro Antonio Cedeño , Zavala Ana Zoila Franco , Tábara Laura Campoverde , Figueroa Rosaura Manuela Mayea , Matamoros Freddy Eladio Torres , Villacrés Lenin Stalin Muñoz , Villacrés Granbay Marcelo Muñoz , Morán Glenda Verónica Figueroa , Anaguano José Federico Suquillo , Pilataxi Jorge Washington Escobar , Moreno María Isabel Guillen , Pozo Carmen Elizabeth Vargas
Published: December 2024

Objective: The objective of this study is to analyze how artificial intelligence can promote educational inclusion and improve the quality of learning for students with special educational needs.
 
Theoretical Framework: In this review article, the main concepts and theories that support the research are presented, such as personalized learning, the model of educational inclusion, and the theory of educational technology, providing solid foundations from an approach that fosters inclusion in higher education.
 
Method: Based on a qualitative approach, 18 scientific articles and 2 books were analyzed regarding the role of AI in inclusive education. The selected participants are researchers who have published in indexed journals with regional and global impact. Data collection was conducted through an exhaustive documentary analysis, focusing on recent studies about educational technologies and their application in inclusive contexts.
 
Results and Discussion: Within the results obtained, it was determined that artificial intelligence has significant potential to personalize learning and facilitate access to education for students with special educational needs. However, limitations were also identified, such as the inequality related to access to technology that affects various socioeconomic contexts.
 
Research Implications: The implications, both practical and theoretical, are analyzed to provide information on how the results can be applied or influence practices in the field of education regarding the development of inclusive educational policies, teacher training, and improvements in access to digital teaching resources.
 
Originality/Value: The relevance and value of this research are evident in its ability to inform about new pedagogical strategies that integrate emerging technologies in the classroom.
NUPEM/UEPG Project – Evaluation of The Implementation Process in The Ponta Grossa Social Complex
Authors: Gross Junior Rauli , Silva Silmara Carneiro e , Silva Gislaine do Rocio Rocha Simões da , Laat Erivelton Fontana de , Goldman Barbara Louise , Silva Aladison Roberto da
Published: December 2024

Objective: This study investigates the implementation process of the Extension Project "Nucleus for Assistance to People with Electronic Monitoring" (NUPEM/UEPG) and its relationship with the social reintegration of monitored individuals. Developed in partnership between the Department of Penal Management of the State of Paraná (DEPPEN) and the State University of Ponta Grossa (UEPG), the project integrates the fields of Law, Psychology, and Social Work.
 
Theoretical Framework: The research is based on approaches from Critical Criminology and the Economic Theory of Crime, considering structural and social factors that impact the reintegration process.
 
Method: The analysis is based on data collected from 660 monitored individuals in the region of Ponta Grossa between July and September 2023. Socioeconomic and social vulnerability indicators, such as income, education, and labor market participation, were evaluated.
 
Results and Discussion: Despite being in its initial phase, the project shows positive trends, including a reduction in incidents during the analyzed period. However, challenges persist related to social vulnerability and the stigma associated with the use of electronic monitoring devices.
 
Research Implications: This study contributes to the advancement of public policies for decarceration, proposing strategies to strengthen interdisciplinary practices and promote greater social inclusion for monitored individuals.
 
Originality/Value: The research highlights NUPEM/UEPG's innovative role in integrating academia and the penal system, providing evidence to improve social reintegration policies aligned with the 2030 Agenda.
Port Management Strategy of Porto Velho, Productive Capacity in The Amazonian Context
Authors: Silva Vitor Gregorio da , Pedro Filho Flávio de São , Silva Franklin Menezes da
Published: December 2024

Objective: The objective of this study is to interpret the management strategy and production capacity of the Public Port in the capital city of Porto Velho.
 
Theoretical Framework: Port management in the Amazon requires research that can provide strategic insights, considering the region's complexity. Key concerns revolve around productive capacity and distribution at national and international levels. Therefore, understanding the Theory of Economic Development proposed by Joseph Schumpeter; the Contingency Theory regarding dynamics in organizational management; defining SWOT Analysis applied to port production capacity; and Innovation Concepts related to operations and technologies are essential for the development of this study.
 
Method: This investigation adopts a Case Study method and related procedures within a qualitative research approach. Using SWOT analysis, the study proposes a convergence approach focused on overcoming weaknesses and threats while aiming to leverage strengths and opportunities to achieve excellence.
 
Results and Discussion: The findings identified areas for improvement, such as opportunities for managing production capacity in ports, which include strategic planning to balance the demand for port services with the supply of operational capacity. Additionally, the automation, digitization, and adoption of sustainable technologies are critical for ports to adapt to the growing demands of international trade and remain competitive.
 
Research Implications: This study is of interest to governments, entrepreneurs, and leaders involved in formulating policies for integrated and sustainable local development. It also serves as a valuable academic resource for studies with similar themes.
 
Originality/Value: Understanding the production capacity of the Public Port is fundamental to developing strategies aimed not only at improving existing infrastructure but also at promoting an economic environment that supports growth and regional competitiveness. The study contributes to discussions on the importance of ports in the Amazonian and national economy and emphasizes the need for continuous investment in modernization and efficient management of these critical spaces for foreign trade policies.
Evaluation of iron, iron binding capacity, transferrin, some oxidative stress markers and hematological parameters in foot and mouth disease in cattle
Authors: Sezer Mert , Gezer Tahir , Merhan Oğuz , Akyüz Enes , Bozukluhan Kadir , Gökce Gürbüz
Published: December 2024

This study aimed to investigate the changes in serum iron, iron binding capacity, transferrin, some oxidative stress markers, and hematological and biochemical parameters in cattle infected with foot-and-mouth disease and to reveal their importance. The animal material of the study was composed of 20 Simmental cattle between 6 and 12 months of age, which were diagnosed with foot-and-mouth disease based on the results of the clinical and laboratory examinations (patient group), and the control group was composed of 10 animals selected from a different herd, with the same age group and breed characteristics and fed with the same ration. Among the hematological parameters examined in the study, the total leukocyte count (WBC (x103/μL)) was found to be higher in the patient group with statistical significance compared to the control group (P
Effect of seminal plasma treatment on conception rate in ovsynch treated holstein cows
Authors: Baştan İlktan , Çetin Yusuf
Published: December 2024

The seminal plasma (SP) plays significant roles in fertilization processes including capacitation, acrosome reaction, and interaction between sperm and the oocyte. In addition, the SP provides an immunomodulatory effect by the cytokines that it contains, in the female reproductive tract. The aim of this study was to investigate the effect of intrauterine seminal plasma infusion on the success of artificial insemination (AI) in Holstein cows. In the study, a total of 60 multiparous Holstein cows were treated with the Ovsynch protocol (10 μg GnRH on day 0, 500 μg PGF2α on day 7, and 10 μg GnRH on day 9), and artificial insemination was performed 16-18 h after the second GnRH. The cows were categorized into four groups based on the number of AI during lactation period; Group-I (Control AI≤2): inseminated once or twice, Grup- II (SP+AI≤2): inseminated once or twice and infused intrauterine SP, Grup-III (Control AI≥3): inseminated thrice or more, Grup-IV (SP+AI≥3): inseminated thrice or more and infused intrauterine SP. SPs were obtained from 5 Holstein bulls. They were mixed and infused into the corpus uterine immediately before AI. Pregnancy diagnosis by ultrasonography was performed on the 32nd, 60th and 95th days after AI. The conception rates were found 53.3%, 60%, 26.6% and 40%, respectively, between the groups at the 32nd and 60th days after AI (P>0.05). The pregnancy loss was found only in two cows (25%) of Group I, on the day 95th (P>0.05). The days of lactation between the groups were 110±23.2, 104±28.2, 238±53 and 221±46.7, respectively, and were found to statistically significant (P<0.05). The results indicate that the application of seminal plasma is promising for pregnancy success in re-inseminated cows. However, it is considered that further studies based on proteomics or gene expression profiles of seminal plasma and uterine tissue in a large cow population are needed to verify this prediction.
Unveiling Thyroid Cancer Precision: Significance of Molecular Markers for Risk Stratification and Management
Authors: Shabbir Hamid , Ahmad Warda , Imran Muhammad
Published: December 2024

This commentary delves into the significance of molecular markers, specifically BRAF and TERT mutations, in refining risk stratification and management strategies for thyroid cancer, with a focus on optimizing radioactive iodine (RAI) doses. BRAFV600E mutation notably impacts risk classification in papillary thyroid cancer (PTC), elevating it to intermediate-risk status and affecting recurrence rates. Additionally, the inclusion of TERT promoter mutation in risk assessment categorizes PTC larger than 1cm as high-risk. The initial maximum permissible RAI dose, tailored to the respective risk group, targets heterogeneous tumor cell populations, including those with poor RAI uptake due to mutations, by utilizing the cross-fire effect of radiation, thereby reducing the risk of recurrence. BRAF mutational analysis aids in ruling out follicular neoplasms, while TERT mutational analysis facilitates tailored management, particularly in follicular tumors of uncertain malignant potential (FT-UMP). Although current guidelines don't advocate RAI dose modification based solely on molecular markers, ongoing research emphasizes the need for exploration. Proactive integration of BRAF and TERT mutational analysis pre-RAI therapy enhances risk stratification, facilitating personalized treatment decisions. It's recommended to conduct mutational analysis for BRAF and TERT genes before initiating RAI therapy in PTC and RAS+TERT in FTC for improved risk assessment and tailored RAI administration. As molecular insights advance, personalized approaches are vital for optimizing patient outcomes in thyroid cancer management
Romain Gary dans les pas de Conrad… francophonie sublimée ou francophonie déchirée?
Authors: Roumette Julien
Published: December 2024

Romain Gary, né à Wilno, se plaisait à se reconnaître comme une sorte de « Conrad français »… mâtiné de Gogol. Il est l’exemple même d’une polyglossie féconde, d’un don des langues qui le conduit à une francophonie toute en inventivité et en transgression, qui ne cesse de prendre des libertés avec la langue qu’il a adoptée et qu’il finit par réinventer joyeusement sous le pseudonyme Ajar. Derrière le désir d’assimilation et les succès littéraires, frappe l’insistance à maintenir une forme d’étrangeté, qui va en s’accentuant dans son œuvre. Comme s’il s’agissait de ne surtout pas oublier d’où l’on vient… même et surtout quand on accède à la plus grande reconnaissance littéraire.
Quelques jalons pour l’étude des francophonie et francographie polonaises
Authors: Szczur Przemysław
Published: December 2024

L’article propose une vue d’ensemble des francophonie et francographie polonaises. Adoptant une perspective historique, l’auteur examine à la fois les facteurs qui ont contribué à la diffusion du français en Pologne et ceux qui ont conditionné le choix de cette langue comme outil d’expression littéraire par un certain nombre d’auteurs polonais. À partir d’exemples individuels, il essaie de restituer les logiques collectives ayant motivé ce choix. Les facteurs relevés sont l’importance du plurilinguisme en Pologne, l’ampleur de la diffusion du français parmi les élites sociales polonaises, l’influence d’événements politiques tels que la Révolution, les guerres napoléoniennes ou les nombreuses insurrections polonaises du XIXe siècle, qui ont favorisé l’émigration de nombreux Polonais et Polonaises vers des pays francophones, le rayonnement culturel de la France, mais également, surtout aux XXe et XXIe siècles, le rapport problématique au polonais de certains auteurs d’origine juive après la Shoah, la possibilité d’utiliser le français comme « langage secret » pour aborder des tabous sociaux ou encore celle d’exploiter esthétiquement ses particularités (p.ex. phonétiques).
Clinical Experience of Professor Bai Changchuan in Traditional Chinese Medicine
Authors:   Dalian Traditional Chinese Medicine Hospital, Changchuan Bai
Published: December 2024

This article aims to summarize Professor Bai's contributions to the development and extension of TCM theories and his clinical experience in treating various diseases for reference and learning by peers
Monoclonal Anti-CD47 Therapy and its Haematological Effects, including Anaemia and Thrombocytopenia
Authors:   Discipline Of Laboratory Medicine, School Of Health And Biomedical Sciences, STEM College, RMIT University, Bundoora, Victoria, Australia
Published: December 2024

Monoclonal anti-CD47 therapy is a new form of immunotherapy, which has been used in a clinical setting in recent years for the treatment of haematological and solid malignancies. Anti-CD47 functions by blocking the CD47-SIRPα interaction and promotes the phagocytosis of cancer cells, which attempt to invade the immune systems mechanisms via this interface.
Mental health related experiences among African Caribbean, and Black immigrant and refugee families living with HIV/ AIDS in Greater Toronto Area, Canada
Authors: Kamanzi Joyce , Khanlou Nazilla , Ongoiba Fanta , Khan Attia
Published: December 2024

Introduction: In 2021, there were nearly 38 million people living with HIV worldwide and approximately 61,110 in Canada. Africans, Caribbean people, and the Black community make up less than 3.5% of the Canadian population, but account for 22% of people living with HIV in Canada. Our study explores the mental health related experiences of African, Caribbean, Black immigrant families living with HIV in Canada’s Greater Toronto Area.  Methods: A qualitative descriptive study was carried out between September, 2022 and December, 2023. Purposive sampling was used to select 20 participants, and semi-structured interviews were conducted. Content and thematic analyses of data were performed. Results: Participants ranged in age from 32 to 73 years, 60% were female, the majority had only completed college (65%), and most of them were not working. Three themes were identified: 1) HIV related struggles (neurocognitive impairment, HIV-related stigma and shame, racism and discrimination, and the impact of HIV-related stigma on mental health); 2) Systemic barriers (racism, stereotyping, systemic discrimination, employment and housing issues); and 3) social network building (isolation and solitude, disclosure dilemma). Discussion: Intersecting and complex factors associated with immigration and resettlement of African immigrants living with HIV affect their mental health and that of their families. Isolation and social exclusion are major stressors for these families, and their mental health is compromised by everyday encounters with systemic barriers. Conclusion: African immigrants and refugees living with HIV/AIDS experience mental health challenges related to co-morbidities caused by the HIV Virus. Integration of mental health services into HIV services would strengthen HIV prevention and care outcomes and improve access to mental health care.
Keywords: Immigrants and refugees, HIV/AIDS, mental health, families, Canada.
Expression of the Recombinant Protein Substrate for Detection of the Endopeptidase Activity of Botulinum Neurotoxin Serotype B
Authors: Anh Le Phan , Phuong Vu Thi , Yen Pham Bao , Nhung Le Thi Hong , Nghia Phan Tuan , Loan Nguyen Thi Hong
Published: December 2024

Botulinum neurotoxins (BoNTs) produced by Clostridium botulinum are metalloproteases. Based on structural differences and substrate specificity, BoNTs are classified into 8 serotypes from A to H. Identification of the endopeptidase activity of BoNTs is the basis for BoNT detection. In this study, a recombinant gene encoding for the substrate of the BoNT serotype (BoNT/B) was successfully cloned and expressed in E. coli BL21(DE3) using a pET28CYL1 vector. At the N-terminus of the designed recombinant protein, there was 6´His tag along with an enhanced cyan fluorescent protein. The C-terminus held an enhanced yellow fluorescent protein, while a peptide with amino acid sequences spanning from 60 to 94 residues of VAMP2 (a natural substrate of BoNT/B) was positioned in the midsection. The whole construct was called 6´His-CFP-VAMP2(60-94)-YFP, with a molecular weight of approximately 60.1 kDa. The substrate protein exhibited a high level of expression in the soluble fraction of E. coli BL21(DE3), which was purified via Ni-affinity chromatography to electrophoretic homogeneity. The extracellular fluid of C. botulinum serotype B (crude BoNT/B) cleaved the recombinant protein to generate two smaller protein fragments that are consistent with theoretical calculations. Crude BoNT/B required the presence of dithiothreitol (DTT) for substrate proteolytic cleavage, but it was inhibited by ethylene diamine tetraacetic acid (EDTA).
Efektivitas Pemungutan Retribusi Tempat Rekreasi Taman Margasatwa Ragunan Terhadap Pendapatan Retribusi Daerah Provinsi DKI Jakarta Tahun 2022
Authors: Khoerudin Miftah Farid , Inayati Inayati
Published: December 2024

This study aims to analyze the effectiveness of levy collection at Ragunan Wildlife Park in 2022 and its contribution to the Regional Revenue (PAD) of DKI Jakarta Province. Levy collection is an important source of income for the local government; however, there are several challenges affecting its effectiveness, such as stagnant ticket prices since 2011 and issues with the JakCard payment system. The research employs a descriptive qualitative method, with data collection through observation, interviews, and documentation. Informants were selected using purposive sampling. The findings show that the effectiveness of levy collection at Ragunan Wildlife Park in 2022 was 77%, which is considered fairly effective, although there are still some obstacles. The factors affecting effectiveness include unadjusted levy rates in line with economic developments and technical issues with the JakCard payment system that disrupt the transaction process. Therefore, it is recommended that the local government review levy rates and improve the payment system to enhance the effectiveness of levy collection and its contribution to the PAD of DKI Jakarta Province.
Responsabilidad civil por daños nucleares: un paso adelante tras la ley 11/2023, de 8 de mayo
Authors: Sánchez Hernández Carmen
Published: December 2024

Nuclear energy benefits society, but it also entails risks to life, health, and the environment. As a human and risky activity, legislation requires careful consideration. The adoption of preventive measures to achieve maximum safety in the use of nuclear energy does not completely exclude the risks derived from the use of this technology. This necessitates the development of both international and national regulations, aimed not only at preventing harm but also at compensating for the effects that an accident may have caused, respecting the principles of peace, technological safety, physical security, responsibility, and cooperation, in order to provide a legal basis that guarantees the development of a peaceful use of nuclear energy.
“Menores vulnerables y redes sociales: nuevos retos jurídicos en la protección ante el uso inadecuado: edad, educación y controles por defecto”
Authors: Morillas Fernández Marta
Published: December 2024

El uso inadecuado de los menores en la sociedad digital, como personas especialmente vulnerables, les lleva a asumir unos riesgos que les afectan tanto a su salud como a la vulneración de sus derechos. En el presente trabajo, se analiza la realidad actual y los nuevos retos jurídicos y tecnológicos que se prevén, para fortalecer las medidas de protección y garantía de los niños, niñas y adolescentes en el entorno digital. Con especial atención a las consecuencias en su desarrollo, a la edad y madurez para la licitud del consentimiento, y en los avances normativos para la prevención y protección, especialmente en lo referente a la educación, controles parentales y sistemas de verificación de la edad.
Hitos relevantes en la doctrina jurisprudencial y registral en aplicación de la ley 8/2021, de 2 de junio: luces y sombras en sus tres años de vigencia
Authors: Vivas Tesón Inmaculada
Published: December 2024

Tras tres años de rodaje de la Ley 8/2021, contamos ya con un número considerable de sentencias de la Sala 1ª del Tribunal Supremo y resoluciones de la Dirección General de Seguridad Jurídica y Fe Pública. En el presente trabajo, a través de unas y otras, exploramos cuáles son los avatares y las cuestiones más problemáticas que, en la práctica, está suscitando la aplicación de tan importante reforma, así como las soluciones judiciales y registrales que, con mayor o menor tino, se están dando a las mismas, las cuales nos permitirán reflexionar y extraer algunas ideas clave.
Recensión bibliográfica: M.ª Angustias Martos Calabrús. El defensor judicial de la persona con discapacidad
Authors: Arroyo Moreno Ana María
Published: December 2024

La figura del defensor judicial ha cobrado una relevancia indiscutible en el contexto jurídico contemporáneo, especialmente en lo que respecta a la protección de los derechos de las personas con discapacidad. En una sociedad que aboga por la inclusión y el respeto a la autonomía, el defensor judicial se ha convertido en una de las herramientas más fundamentales para garantizar que las personas con discapacidad puedan ejercer plenamente sus derechos, sin que sus derechos puedan ser restringidos por terceros, incluidas aquellas personas encargadas de brindarles apoyo.
 
La Ley 8/2021, que modifica la legislación española en materia de capacidad jurídica para adaptarse a la Convención de las Naciones Unidas sobre los derechos de las personas con discapacidad, ha revolucionado la concepción de las medidas de apoyo, donde la figura del defensor judicial adquiere un protagonismo especial. A través de este cambio legislativo, se busca que las decisiones que afectan a las personas con discapacidad sean tomadas de acuerdo con su voluntad, deseos y preferencias, promoviendo un modelo donde la persona con tiene el control de sus propios asuntos, en la medida de lo posible.
La obra de María Angustias Martos Calabrús no solo constituye una contribución esencial al campo del derecho de familia y la discapacidad, sino que también marca un hito en la reflexión sobre la evolución del derecho y su capacidad para adaptarse a las necesidades de las personas con discapacidad en una sociedad moderna. A lo largo de su carrera, la autora ha demostrado un compromiso inquebrantable con los derechos de las personas más vulnerables, y este libro refleja esa dedicación y profundidad de análisis.
QbD Based Formulation Development of Delayed-Release Beads for Better Management of Nocturnal Asthma
Authors: V Vijaykumar , Y Ismail , U Ubaidulla , K Pradeep
Published: December 2024

The present study discusses about the quality by design (QbD) based formulation development and characterization of delayed release beads for better management of Nocturnal Asthma. Ionotropic gelation technique was used to create Budisonide-loaded pectin-alginate beads, and calcium chloride was added as a crosslinking agent. The central composite design model was used to optimize the beads. The response of beads was 91.9861 % for loading efficiency, 0.998 mm for bead size, and 360 min for time required for 90% drug release. The optimal formulation variables for a formulation were found to be 4.14 mg of pectin, 1.82 mg of alginate, 14.36% of CaCl2, and 5.99 hours of cross-linking time. PEC-ALG beads showed no release in 0.1 N HCl (pH 1.2). In contrast, increased Ca2+ and Na+ ion exchange as well as solvent penetration into the pectin-alginate network have been linked to the quick release from cross-linked beads in phosphate buffer pH 7.4. FTIR results showed that there was no interaction between the medication and the polymers, as evidenced by the significant peaks of BUD detected in the beads. An in vitro study of the toxicity of beads on A549 cell lines revealed significantly higher cell viability than the group of cells treated with pure BUD.BUD loaded PEC-ALG beads could have potential for chrono modulated delivery system for targeting nocturnal asthma.
Formulation and Evaluation of Microspheres of Tinospora cordifolia
Authors: PP Mehta , AD Waghmode .
Published: December 2024

With so many medicinal benefits, Tinospora cordifolia is among the most adaptable revitalizing plants. In the present research work, microspheres of Tinospora cordifolia ethanolic extract were formulated by using emulsion solvent diffusion method. Evaluation parameters of the prepared formulation like powder density viz. bulk and tapped density, Hausner’s ratio, percent compressibility and flow properties were checked. Phytochemical evaluation indicated presence of glycosides, alkaloids, tannins, phenols, starch, and sterols in the plant. The purpose of the current investigation was to check the antibacterial efficacy of T.cordifolia microspheres made. The same was achieved by using recommended microbiological strains viz. Bacillus subtilis and Staphylococcus aureus. The prepared formulation exhibited potent antibacterial activity against both bacterial strains.
Formulation and Selection of Immediate Release Layer for Designing the Paracetamol Sustained Release Tablets Based on In vitro Profile
Authors: R Kundharaju , CSP Kumar
Published: December 2024

This study focused on designing paracetamol immediate release (IR) layers using three disintegrants- Banana starch (BS), Sodium starch glycolate (SSG), and Croscarmellose sodium (CCS)- at concentrations of 2%, 4%, 6%, and 8% (w/w).A total of 24 formulations are prepared: 12 via direct compression (IL1-IL12) and 12 via wet granulation (IL13-IL24). Pre-compression properties (bulk density: 0.45-0.48 g/cm3, tapped density: 0.55-0.60 g/cm3, Carr’s index: 11.8%-20%, Hausner’s ratio: 1.22-1.25) and post-compression parameters (weight variation: 0.9%-1.6%, hardness: 5.45-5.6kg/cm2, friability: 0.1%-0.4%, in vitro wetting time: 1.44-4.4 minutes, in vitro disintegration time: 1.4-4.4 minutes were within acceptable limits. Direct compression formulations exhibited superior dissolution rates, with fold enhancements of 1.22 (BS), 1.23 (SSG), and 1.18 (CCS) compared to wet granulation. Formulations IL4, IL8, and IL12 (8% disintegrant, direct compression) demonstrated optimal dissolution and mechanical properties, making them the final IR layers selected for sustained release (SR) tablet design. These findings support their potential application in fever management in conditions such as COVID-19.
From Challenges to Advancement for Bilayer Tablet Technology as Drug Delivery System
Authors: K Kulkarni , G Deokar
Published: December 2024

Bilayer tablet technology is in focus because it advantageous for combination therapy, for combining two different release profile and it gives patent novelty to existing dosage. Hence its advantages, challenges and applications need to be discuss. The objective of preparing a review article on bilayer tablets is multifaceted, aiming to cover challenges at formulation development to scaleup and opportunity for new product development by integrating it bilayer tablet technology with other formulation technology. With reference to all the electronic data it was found that bilayer tablets face many challenges from formulation development till commercial manufacturing like interfacial bonding strength, layer separation, effect of environment on bonding strength bilayer tablet. But all these challenges can be over come by resolving appropriate remedies like using plastic diluent in both layers, manufacturing bilayer tablet using appropriate bilayer tablet manufacturing machine, etc. going forward with this challenges bilayer tablets puts advantage like it can be use for combination therapy, for chronotherapeutic therapy, enhancing therapeutic activity by altering micro environmental pH etc. Review comprises the information of key challenges to be consider while selection of excipients during formulation development, challenges related to process of bilayer tablet manufacturing and manufacturing bilayer tablet by integrating it with novel drug delivery systems and processes for enhancing therapeutic effectiveness and patient compliance
Hydro-Oceanographic Conditions in the Development of Tinobu Port Lasolo Sub-district North Konawe Regency Southeast Sulawesi Province
Authors: Chaerul Muhammad , Usman Rizki
Published: December 2024

Indonesia is one of the world's largest maritime countries, with many small islands scattered from Sabang to Merauke. Therefore, the presence of a port plays a crucial role in maritime transportation, which is highly essential for the Indonesian population. When planning a port, there are numerous aspects to consider, ranging from environmental to structural aspects of the port's development.
In this context, researchers conducted a study to analyze the water conditions around Tinobu Port, specifically focusing on topography, bathymetry, and tides, often referred to as Hydro-Oceanography. These three aspects of Hydro-Oceanography play a vital role in port planning, as topography and bathymetry shape the land and water contours, and tidal analysis determines elevation bindings.
Mineralogical and Geochemical Clay Analysis for Portland Cement Quality Distribution: A Study Case From Ajibarang District, Central Java, Indonesia
Authors: Abidin Izdihar Sahda , Siswandi  , Gibran Akhmad Khahlil
Published: December 2024

Nowadays, the development of infrastructure has caused an increase in the need for cement. To determine the suitability of the raw materials used in cement production, an assessment must be carried out on the quality anMineralogical and Geochemical Clay Analysis for Portland Cement Quality Distribution: A Study Case From Ajibarang District, Central Java, Indonesiad suitability of the cement raw materials. This research was conducted in Halang Formation of the Tipar Kidul area and around Banyumas Regency, Central Java. The methods used are X-ray fluorescence (XRF) and scanning electron microscopy (SEM). Data from XRF analysis generally shows SiO2 values from 26.83% to 57.75%, Al2O3 values from 11.18% to 20.23%, and Fe2O3 values from 3.21% to 8.76%. Judging from the aluminum index (AI) content, the ideal cement raw materials are two samples with a proportion of 3.17% to 3.22%. The results of SEM analysis show that there are illite, calcite, quartz and smectite minerals in the claystone research area. Based on data, almost 75% of the claystone survey area was found to be suitable as a raw material for cement. This research has a positive impact on the characterization of limestone as a raw material for cement by utilizing geochemical analysis and electron microscopy to achieve a more comprehensive understanding of the evaluation of limestone quality.
Calibration of the Water Balance Model for the Upper Cimanuk Catchment Area for Raw Water Supply
Authors: Permana Sulwan , Susetyaningsih Adi
Published: December 2024

The main task of PDAM Tirta Intan Garut Regency is to manage raw water into clean water for customers. The management of raw water supply in Bayongbong District for the community still relies on springs with a gravity system, deep well pumps and rivers. The flow of the Cimanuk River in Bayongbong District can be used to provide raw water. Four rainfall stations are used. Average rainfall is calculated using the Thiessen method. The raw water collection point does not have a automatic water level recorder (AWLR), so it is necessary to create a model to obtain the discharge at the collection point. The model used is the water balance model from F.J. Mock. Calibration of model parameters was carried out on observed discharge at Cimanuk-Bayongbong AWLR and Cimanuk-Bojongloa AWLR. To test the reliability of the model, NSE and RMSE values ​​were used. The NSE and RMSE values ​​in the Cimanuk-Bayongbong catchment area are 0.515 and 3.615 and Cimanuk-Bojongloa are 0.593 and 4.813. The results of the model parameter calibration are used to calculate the discharge at the collection point. The calibration result ​​at the collection site are exposed surface 50%, infiltration coefficient 0.5: recession coefficient 0.35: catchment area characteristic factor 10%; and soil moisture capacity 200 mm. The dependable flow is calculated based on Q90% probability, water availability in July, August, September and October is 0.078 m3/s; 0.025 m3/s; 0.035 m3/s; and 0.025 m3/s. Water availability in that month is smaller than the discharge requirement for the next five and ten years, namely ranging from 0.134 m3/s to 0.168 m3/s and 0.145 m3/s to 0,182 m3/s.
Mapping of Basin Substrate and Vulnerability Index of Shallow Waters of Combol and Citlim Island, Moro District, Karimun Regency, Riau Islands Province, Indonesia
Authors: Aunurrahman  , Hanifa Irfan , Setiyaningsih
Published: December 2024

Mapping basin substrates and vulnerability indexes in shallow waters are crucial for understanding the ecological health and resilience of marine ecosystems. Given the increasing threats from climate change and human activities, this research provides essential insights for effectively managing and conserving these vital coastal environments. Our study discusses mapping the bottom substrate and the vulnerability index of shallow waters in the Combol and Citlim Island clusters, Moro District, Karimun Regency, Riau Islands Province. Shallow waters have rich ecosystems, including coral reefs and seagrass beds, which function as fish habitats and coastal protection. However, these ecosystems are vulnerable to climate change and pollution disturbances. Using the water column correction method, this study used Sentinel-2A multispectral satellite imagery to map the shallow water bottom habitat. The analysis showed that open substrates and dead corals dominated the habitat, with an area of ​​± 766.8 Ha and ± 682.5 Ha, respectively. The vulnerability index revealed that a total area of approximately 393 ha fell into the moderate vulnerability category. Our mapping result is essential for understanding ecosystem dynamics and formulating appropriate conservation strategies. We anticipate that these findings will offer valuable insights for managing aquatic resources and safeguarding coastal ecosystems in the region.
Extraction, Identification and Characterization by Sds-Page Method of Collagen Extracted from Rhizostoma Pulmo, a Jellyfish Found in the Black Sea Basin
Authors: Pesterau Ana-Maria , Sirbu Rodica , Cadar Emin
Published: December 2024

Collagen is one of the proteins that plays an important role in many biomedical and cosmetic applications. The present study investigates collagen extracted from the jellyfish Rhizostoma pulmo, a species native to the Black Sea basin. The method of extracting collagen from the marine organism is described. The SDS-PAGE (Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis) method, an efficient technique for the separation and analysis of proteins according to molecular weight, was used to identify and characterize the protein structure of the extracted collagen. The collagen samples obtained were purified and subjected to electrophoresis, demonstrating a specific band corresponding to type I collagen, the main type of collagen found in marine organisms. The results show a protein structure similar to that of collagen isolated from other marine sources, indicating the high potential of Rhizostoma pulmo as a source of collagen for industrial applications. This research contributes to the development of sustainable methods for the valorization of marine resources from the Black Sea basin in fields such as regenerative, tissue, dermato-cosmetic, nutraceutical and even food medicine.
Strategi Pengembangan Usaha Sarang Walet di Kecamatan Abeli Kota Kendari
Authors: Hasanah Uswatun , Bafadal Azhar , Zani Munirwan
Published: December 2024

Business competition is one of the main threats faced by swiftlet nest entrepreneurs, necessitating the implementation of appropriate strategies to enhance competitiveness. This study aims to design strategies for the development of swiftlet nest businesses. Qualitative and quantitative descriptive analysis methods were employed to describe the internal and external conditions of the swiftlet nest business, while SWOT analysis was used to formulate alternative strategies for its development. The results of the study indicate that the strategies that can be implemented by swiftlet nest entrepreneurs align with a strength-opportunity approach, involving the following steps: (1) Utilizing modern technology to advance and develop the business both offline and online, thereby creating effective marketing channels; (2) Selecting strategic business locations to ensure the comfort and habitation of swiftlets, resulting in higher-quality and more beneficial nests; and (3) Optimizing the use of capital, which plays a critical role in maintaining the financial stability of swiftlet nest entrepreneurs.
Hubungan Karakteristik Sosial Ekonomi dan Biaya Produksi terhadap Pendapatan Usahatani Lada di Daerah Perbatasan
Authors: Paulina Yohana , Yurisinthae Erlinda , Kurniati Dewi
Published: December 2024

Pepper farmers' income is often influenced by various factors, both socio-economic and production costs. The aim of this research is to analyze the correlation between farmers' socio-economic characteristics and production costs on pepper (Piper nigrum L) with farming income. The data analysis method used is Spearman Rank Correlation and descriptive data scaling techniques. The research findings show that, regarding farmers' socio-economic characteristics, the factor that has a strong relationship with pepper farming income is age, while education and experience have a moderate relationship. Land area and dependents, on the other hand, show a weak relationship. In terms of production costs, the factor that has a strong relationship is fertilizer expenses, the factor with a moderate relationship is chemicals, while labor, depreciation, and taxes do not show a significant relationship.
Long-Term Savings as a Source of Oil Palm Replanting Financing
Authors: Vinota Livia , Maryadi Maryadi , Bidarti Agustina
Published: December 2024

Replanting activities are one of the ways to maintain the productivity of oil palm plants. The large costs required in replanting indicate that financial planning is needed to ensure the implementation of replanting can be realized properly. This study aims to calculate the value of savings to prepare for the needs of oil palm replanting funds and provide recommendations for the implementation plan of long-term savings activities that can be carried out by oil palm farmers. This research method uses a quantitative-qualitative method. The key informants in this study were officers at KPKS Suka Makmur and employees at Bank Sumsel Babel. The informants were selected by purposive sampling by considering their expertise in oil palm replanting activities and long-term savings products. Based on the results of the research, it is known that the value of savings that must be prepared by farmers in one month is IDR 294,256.54 per hectare. Farmers can save their savings in two schemes, which are using an institutional account or a personal account. It is expected that farmers can prepare replanting funds through regular monthly savings through long-term savings in the name of an institution or group. In addition, there is a need for socialization and discussion by cooperatives or farmer groups to their members regarding the future financial plans of oil palm farming so that farmers can properly prepare for the needs of oil palm replanting funds