bluuebunny/crossref_metadata_2025 huggingface dataset:
Riders to the Sea between Regionalism and Universality: A Cultural Perspective
Authors: Kitishat Amal Riyadh
Published: February 2019

This study aims at discussing Riders to the Sea; it aims to investigate nationalism and cultural identity as two significant ways against the English cultural colonialism. Though many critics regard J.M. Synge as; and thus consider him as an example of regional dramatist because his works are related to the local Irish material. However; this study aims to correct this vision of Synge as only about Irish Celtic culture, but as an innovator of the Irish theatre and as a culturalist who shifted Irish theatre into a universal scope. Thus, though Synge's fame is due to his treatment of the "folk" drama; still, he finds in Ireland’s folk tales, myths, and traditional legends a rich source for universal interests. By tracing the reinforcement of the Irish setting and oral culture for a cultural function which aims at establishing the Irish identity and reviving its national heritage, the study argues that Synge's dramatic presentations were not only of regional or local value; but also of international and cultural significance. That is though J.M. Synge introduces his theme in a local Irish context, with a particular focus on peasants; he was able to transform the Irish theatre from the local context to universality.
EFL Learners’ Reflections on Cooperative Learning: Issues of Implementation
Authors: Alghamdy Rashed Zannan
Published: February 2019

This study has described and identified the opinions and experiences of the EFL learners who participated in CL English lessons. The participants in this study were 10 tenth-grade male students, aged 14-15 years in four boys’ secondary schools in Al-Baha city. Two English teachers were asked to implement cooperative learning in their classrooms for 12 weeks. The researcher interviewed ten randomly selected students from the cooperative learning classes at the end of the study.The results and findings of this study showed that most students found that CL enabled them to improve their English skills, make new relationships with others classmates, perform different roles, improve their oral presentation skills, build their self confidence, take on responsibility, respect different opinions and offer their different views, increase their motivation, and develop their friendships with their classmates.However, there were few drawbacks and obstacles to using the CL method. These included: low achiever EFL learners depending on high achiever learners, classmates not giving group members a chance to state their opinions, and poor group member distribution and supervision by the teacher. In the following chapter, the researcher presents a general discussion of the results in this study.
The Study of Chinese-English Public Signs Translation
Authors: He Xuechuan
Published: February 2019

Public signs are special texts that are common in public places. And functions of them are to provide information or to remind readers of some requirements. As China strengthens exchanges with other countries in economy and culture, the translation of public signs was born at the right moment. The public sign translation is an important link in building a harmonious society, establishing an international metropolis and promoting economic development. Firstly, this paper introduces the definition of public signs and summarizes their main features and functions. Secondly, the existing literature and the results of research in China are summarized. By analyzing the problems existing in the Chinese and English public sign translation, this paper puts forward some suitable translation strategies.
Investigating English Academic Writing Problems Encountered by Arab International University Students
Authors: Al-Mukdad Sarah
Published: February 2019

This study is in the area of Teaching English as a Foreign Language (TEFL). It aimed to investigate the academic writing problems encountered by students at Arab International University (AIU) who are taking the Academic Writing module (AWR). The purpose of the study is to investigate this problem from the perspective of students in order to suggest possible treatments to deal with it. The data was collected through distributing a questionnaire to 50 students from different majors at AIU. Upon analyzing and discussing the obtained data, results suggest that students tend to perceive all aspects of academic writing to be difficult. One reason is that they poorly recognize the difference between academic and general English writing due to the lack of background knowledge about writing academically. Another prime reason is attributed to having problems in different linguistic elements even at this supposedly high proficiency level. The study concludes with suggesting a number of ways to address this issue.
The Development of Catholic Schools in the Republic of Sudan
Authors: Alcaide Jorge Carlos Naranjo
Published: February 2019

Sudan is today a country self-defined as Islamic (97% of the population) and Arab. In this context the schools of the Catholic Church have played and play a relevant role in the instruction of the elites of the country and in the provision of education to the displaced and refugee communities (3.58 million persons of concern of UNHCR in 2016). This article studies the development of these schools and their change of role along the following historical periods: the part of the Turco-Egyptian rule that corresponds with the foundation of the first Catholic Schools and the work of the great promotor of education in Sudan, Daniel Comboni (1843-1881); the Anglo-Egyptian Condominium which meant their expansion (1898-1956); and the Independent Sudan where they mainly focused on the service to displaced and refugees (1956-2017). The article describes this evolution and the current situation based upon the revision of published bibliography and unpublished materials from the archives of the Education Office of the Archdiocese of Khartoum and of the Comboni Missionaries in Sudan, especially for the most recent periods.
Expression of anti-apoptothic protein survinin and its gene BIRC5 in primary breast carcinoma as a prognostic factor for the disease
Authors: Shlyakhtunov E. A.
Published: February 2019

Objective:to study the expression of anti-apoptotic protein survivin and its gene BIRC5 in primary breast carcinoma as a potential predictive and prognostic marker.

Materials and methods.Using immunohistochemical methods and real-time polymerase chain reaction 67 samples (biopsy) of the primary breast carcinoma were studied for the presence of expression of survivin protein and its gene BIRC5.

Results.Expression of survivin was determined in 47 (70.15 %) mammary carcinoma samples. Expression of survivin was most often determined in medium and high grade ductal carcinoma (G2–G3), and was associated with lymphovenous stromal invasion in most cases. Expression of survivin protein correlated with the expression of HER2/neu. In 59.6 % of cases survivin was expressed in tumors with a low Ki-67 index. Most often, survivin was expressed in luminal A and luminal B molecular-biological tumor subtypes. Real-time polymerase chain reaction determined the expression of BIRC5 gene in all 67 carcinoma samples. The level of normalized expression of BIRC5 gene significantly moderately correlated with the expression of its product – survivin protein (r = 0.704, p <0.01) and slightly correlated with the expression of oncoprotein HER2/neu (r = –0.285, p <0.05). The median follow-up was 40 months. Overall survival of patients without survivin expression in primary tumor was 100 %, overall survival of patients with survivin expression was 77.16 % (range 74.6–80.1 %) (p = 0.041), relapse-free survival was 100 % and 71.9 % (range 70.1–74.2 %) respectively (p = 0.037). The ratio of progression risks in the survivin expression group was 10.6 (95 % confidence interval 0.85–132.2) (p = 0.041).

Conclusion.Expression of the protein survivin and its gene BIRC5 is an independent adverse prognostic factor and can be used as a predictive and prognostic marker.
Chemoembolization with HepaSpheres as a stage of comprehensive treatment for malignant pelvic tumors
Authors: Kedrova A. G. , Lebedev D. P. , Astakhov D. A. , Kosyy V. V. , Zabozlaev F. G. , Ishchenko R. V.
Published: February 2019

Genital bleeding poses a serious threat to patients with progressive locally advanced malignant tumors. Surgical treatment is often impossible in these patients; therefore, to achieve reliable hemostasis, the patients should undergo embolization of vessels feeding the tumor. Good results have been achieved by selective catheterization of pelvic arteries using chemoembolization with HepaSphere microspheres (Biosphere Medical, France) delivering the therapeutic agent to the tumor. Hydrophilicity of microspheres loaded with cytostatics and their biological compatibility with tissues ensure long-term therapeutic effect by controlling tumor growth. Pronounced hemostatic and antitumor effects of this treatment method have been confirmed by a morphological study. This study analyzes 38 patients that underwent chemoembolization with HepaSpheres loaded with doxorubicin or irinotecan, which allowed surgery and further treatment.
Fluorescence sentinel lymph node mapping in patients with cervical cancer
Authors: Mkrtchyan G. B. , Berlev I. V. , Trifanov Yu. N. , Kozlova E. N. , Ibragimov Z. N. , Urmancheeva A. F. , Mikaya N. A. , Ulrikh E. A.
Published: February 2019

Objective:to assess the efficacy of fluorescence sentinel lymph node (SLN) detection with indocyanine green (ICG) in patients with cervical cancer.

Materials and methods.We analyzed the results of examination and treatment in 80 patients with morphologically verified stage IA1–IIA1 cervical cancer. All patients underwent laparoscopic surgery with fluorescence SLN detection with ICG using a high-resolution infrared camera.

Results.SLNs were detected in 78 out of 80 patients (97.5 %); the rate of bilateral SLN detection was 80.0 % (64 out of 80). SLNs were not identified in 2 patients only (2.5 %). The majority of SLNs (99 out of 176; 56.28 %) were located in the internal group of lymph nodes, near to the common iliac artery bifurcation. Eleven out of 80 patients (13.75 %) were found to have pelvic lymph node metastasis. SLN metastatic lesions were observed in 10 out of 80 patients (12.5 %), whereas only one participant had non-SLN metastasis. Therefore, the sensitivity of the fluorescence method with ICG was 98.75 %.

Conclusion.Fluorescence SLN mapping with ICG in patients with stage IA1–IIA1 cervical cancer is an effective diagnostic method allowing SLN topical diagnosis, intraoperative restaging, and correction of the treatment strategy.
Sentinel lymph nodes biopsy in the surgical treatment of endometrial cancer: history and present
Authors: Ochirov M. O. , Kishkina A. Yu. , Kolomiets L. A. , Chernov V. I.
Published: February 2019

This article reviews the concept of sentinel lymph node biopsy in patients with endometrial cancer. This technique is becoming increasingly appreciated and was included into the latest standards of surgical treatment for gynecological cancers. Sentinel lymph node mapping is a reliable and highly specific (100 %) method, which can be used for determining the indications for adjuvant therapy in addition to a detailed pathomorphological examination that should include immunohistochemical testing and ultrastaging.
RELATIONSHIP BETWEEN CANADA AND THE UNITED STATES: ASYMETRY AND INTERDEPENDENCE
Authors: Derevianko I.
Published: February 2019

The article analyze the nature and content of bilateral Canadian-American asymmetric relations with uses the general scientific methods of empirical knowledge. The asymmetry of quantitative and qualitative parameters of Canada and the USA, which is caused by historical, geographical, political, economic, demographic and cultural factors, is revealed. It is proved that in the conditions of interdependence, the asymmetry of military potentials is not a determining factor in relations between the two North American countries. It found that the existing asymmetry of indicators between Canada and the United States does not create opportunities for the strong side to dictate its conditions and does not allow these relations to be turned into a one-sided relationship. Key Canadian strategies aimed at reducing asymmetry in relations with the United States are identified. It is indicated that “soft power” is an important factor in strengthening Canada’s political position in the asymmetric model of coexistence with the United States. The Relations between Canada and the United States are characterized not only by the high level of asymmetry and the wide application of regulatory mechanisms, but also by the high degree of interdependence that is particularly noticeable in the economic and cultural spheres. The asymmetric relationship between Canadian-American is evident in terms of reaching consensus in a wide range of activities. Key words: USA, Canada, Canadian-American Relations, Asymmetry, Interdependence, Potential.
STRATEGIC PROGNOSES ACCORDING TO THE STRATEGIG PARTNERSHIP PERSPECTIVES FOR UKRAINE
Authors: Rzhevska N.
Published: February 2019

The paper focuses on the strategic partnership formation, important strategic
goals for the partner-states, reaching of which is not easy in terms of ordinary partnership relations. Such goals can be: providing the economic complex with all the necessary resources (energy, goods, financial, informational); secure and safe access to the vital regions; collective way of safety problem solution (organized crime resistance, illegal migration, drugs and weapon smuggling, aggressive separatism, terrorism). Among the conditions on strategic partnership there is a common view of international relations key problems, as well as, global and regional development.
Talking about Ukraine, at the present time it is working on the institutional strengthening of its partnership with the USA. Due to the present situation, euro-atlantic integration is the most appropriate model of behavior for Ukraine. The most important meaning for our state has got the growth of military-technical cooperation with the USA, which is offering direct contracts. This is a security guarantee with is possible only if Ukraine is eligible for NATO membership, where the USA is already a full-fledged member. Not only arming but also economic cooperation with a certain partner, creation of common strategic institutes, are the key strategies. Giving to strategic partnership some new certain meaning depends on the goals and targets which can be reached by its help.
Sanatsal Bir Etkinlik Olarak Fotoğraf Yarışmasının Kültürel Değerlerin Paylaşımına Yansıması: Anadolu Üniversitesi Açıköğretim Fakültesi Öğrencilerinin Görüşleri
Authors: ÜNALAN Halit Turgay
Published: February 2019

Uzaktan eğitim ile sanat, bilişim teknolojilerini ve

tasarım disiplinlerini etkin olarak kullanmaktadır. Bu iki disiplinin

ilişkilendirilmesi ile hedef kitlesi geniş ve yaygın etkisi olan projeler

üretilebilecek bu da uzaktan eğitime ve sanat alanına yeni boyutlar

getirecektir. Açık ve Uzaktan Eğitim ve Güzel Sanatlar eğitimi gibi evrensel

boyutta etkileşim ve iletişimini sağlayan iki disiplinin kesişim noktası olarak

bu çalışmanın bu tür bir araştırmaya duyulan gereksinimi gidereceği

düşünülmektedir. Araştırmanın amacı; bu proje ile gerçekleştirilen sanatsal

etkinlikler ile Anadolu Üniversitesi’ne ilişkin öğrencilerin görüşlerini

belirlemektir. Bu amaç doğrultusunda bilimsel veriler araştırmanın amaçlarını

doğrudan destekleyecek şekilde hem Anadolu Üniversitesi’ne ilişkin hem de

sanatsal ve kültürel etkinliklere yönelik öğrenci görüşleri alınarak

toplanmıştır. Araştırmada veri toplama aracı olarak açık uçlu anket ve yarışma

sonunda başarı ödülü alan ve eserleri sergilenmeye değer bulunan 3 öğrenci ile

yarı yapılandırılmış görüşme kullanılmıştır. Anket verileri betimsel analiz

yoluyla çözümlenmiş, görüşme verileri destek veri olarak kullanılmıştır.

Araştırmaya katılan uzaktan eğitim öğrencilerinin tamamı açık ve uzaktan

eğitimin sanatsal etkinliklerle ilişkilendirilmesini çok yararlı bulduklarını

belirterek olumlu görüş bildirmişlerdir. Bu bağlamda bulgulara dayalı olarak;

Açıköğretim sistemi ile öğrenim gören öğrencilere yönelik öğrencilerin aktif

katılımını gerektiren sanatsal ve kültürel etkinliklerin arttırılması

önerilebilir. 
Cyber Bullying Experiences of Middle School Students According to Olweus' Peer Bullying Model
Authors: ERGÜN-BAŞAK Bircan , BAŞTÜRK Emel
Published: February 2019

Bu araştırmada ergenlerin siber zorbalık karşısında nasıl tepkiler verdiklerini Olweus’un Akran Zorbalığı Modeli çerçevesinde incelemek amaçlanmıştır. Bu araştırmaya Türkiye’nin yedi farklı bölgesinden yaşları 12 ve 14 arasında değişen 49 yedinci ve sekizinci sınıf öğrencisi katılmıştır. Araştırmanın verileri odak grup görüşmeleri ve yarı yapılandırılmış görüşme formu aracılığı ile toplanmıştır. Görüşmelerde ergenlere siber zorbalığa tanık olup olmadıkları sorulmuş, bir kısmı tanıklıklarının yanı sıra doğrudan kendilerinin internette maruz kaldığı ya da yaptığı davranışları paylaşmıştır. Verilerin analizinde tümdengelim yaklaşımı kullanılmıştır. Bulgular Olweus’un akran zorbalığı modeline göre sınıflandırıldığında ise katılımcıların daha önce kurban, kurbanın olası savunucusu, zorba, kurbanın savunucusu ve zorbanın gizli destekçisi statüleri ile siber zorbalığı yaşadıkları belirlenmiştir.  Bununla birlikte bu araştırmada katılımcıların Olweus’un akran zorbalığı modelinde yer alan taraf tutmayan, zorbanın takipçisi ve zorbanın destekçisi statülerinde bir siber zorbalık yaşantıları olmadığı ortaya koyulmuştur. Bulgular siber zorbalık sürecinde kurbanların şamar oğlanı olarak etiketlendiklerini, güvenli internet kullanım kurallarına uygun davranmadıklarını ve sosyal destekten mahrum kaldıklarını işaret etmektedir. Kurbanın olası savunucularının ise kurbanın zarar gördüğünün farkında olmalarına rağmen yetişkinlerin ve akranların olumsuz tutumları nedeniyle kurbana yardım etmekten çekindikleri ortaya koyulmuştur. Zorba statüsünde olduğu belirlenen öğrencilerin de davranışlarının sonuçlarını düşünmeden hareket ettikleri ve internet etiğine dikkat etmedikleri bulunmuştur. Ayrıca bu öğrencilerin eğlence, öç alma ve zorbalığa uğrayan kişileri koruma amacıyla zorbalık yaptıkları belirlenmiştir. Öte yandan kurbanın destekçileri grubundaki öğrencilerin açıklamalarına göre yüksek düzeyde empatik anlayışa ve öz yeterliliğe sahip oldukları belirlenmiştir. Bu gruptaki katılımcılar siber zorbalıkla mücadele etmek amacıyla zorbalarla konuşarak uzlaşma,  diğer akranlara kurbanların yanında yer aldıklarını açıkça gösterme, teknolojik becerilerini kullanarak zorbaları engelleme ve zorbalarla yüz yüze kavga etme stratejilerini kullandıklarını belirtmektedir.  Zorbanın pasif destekçileri olan öğrencilerin de en çok dikkat çeken özellikleri kurbanın, zorbaca davranışı hak ettiğini düşündüğünü belirtmektedir.  Bu bulgulara göre Türkiye’de ergenler siber zorbalık deneyimine sahiptir ve siber zorbalık süreci Olweus’un akran zorbalığı döngüsüne benzer şekilde işlemektedir. Çalışma siber zorbalıkla mücadele sürecinin bu statüler dikkate alınarak ve her bir statü için farklı stratejiler geliştirerek yürütülmesinin önemini ortaya koymaktadır. Bu kapsamda kurbanın pasif destekçilerinin, aktif destekçilere dönüşmesinin önündeki engeller kaldırmalı, zorbalar ve zorbaların potansiyel destekçileri için de ergenlerin empati becerilerini geliştirmeye yönelik çalışmalara ağırlık verilmelidir. 
Bank Domestic Outstandings in Central-Eastern-European Countries between 2008 and 2018
Authors: Bozsik Sándor , Gazda Vladimir
Published: February 2019

The economic crisis that broke out in the most developed part of the world in 2008 seriously affected the Central-Eastern-European bank systems. This was no wonder, because these economies were closely linked to the developed countries. Firstly, the Central-Eastern-European banks were mostly owned by large Western-European banks, and the management of these subsidiaries became tougher due to the asset management problems of their mother banks. The current paper examines the deleveraging of bank systems of this area during the crisis and thereafter. A special northern-southern division can be observed among the Central-Eastern-European banking systems, where the border is unfortunately at the northern border of Hungary. During the crisis, the amount of bank outstandings was mostly determined by the economic growth, the starting state of loan-deposit ratio, as well as the uncertainty of sovereign Credit Defalut Spread. In the aftercrisis period the change in outstandings is especially dependent on the non-performing loan ratio and the change in loandepositratio. Hungary is an “off-line” country for all strong correlated variable pairs, so the decrease in domestic outstandings may have country-specific reasons in addition to the general theoretical variables.
Presentation and Testing of the Creeping Trend with Harmonic Weights Method in the Light of Sovereign CDS Prices
Authors: Géczi-Papp Renáta
Published: February 2019

The prediction of financial indicators is not easy, as the influencing factors may change from time to time. The sovereign credit default swap (CDS) spread is a complex measure which helps evaluate country risk, and there are a number of quantitative and qualitative criteria that may have an impact on the price development. The study aims to present and test a relatively new method. Forecasting based on the creeping trend with harmonic weights allows us to manageindependent variables that are not constant in time. The study presents the method and illustrates its effectiveness through an empirical example, using the Hungarian and German five-year USD denominated quarterly CDS spreads.
Prognostic value of broad-spectrum keratin clones AE1/AE3 and CAM5.2 in small cell lung cancer patients undergoing pulmonary resection
Authors: Badzio Andrzej
Published: February 2019

AbstractIntroduction Small cell lung carcinoma (SCLC) is an aggressive pulmonary neoplasm of neuroendocrine origin. Keratins form a large group of intermediate filaments, which are major structural proteins in epithelial cells and carcinomas. SCLC shows a wide spectrum of keratin expression, from very strong to completely negative. The prognostic role of keratin expression in SCLC is unknown.Material and MethodsTumor tissue microarray samples from a unique series of 82 SCLC patients who underwent pulmonary resection were stained with keratin specific antibodies AE1/AE3 and CAM5.2. The percentage of positively stained cells and their staining pattern (diffusely membranous, partially membranous and dot-like) were evaluated. The median expression value was used for the distinction between keratin-negative and -positive patients. Overall survival in respective groups was compared using the log-rank test. Multivariate Cox proportional hazards regression analysis was performed adjusting for age, gender, tumor site, tumor stage, and tumor histology.Results Median expression of AE1/AE3 and CAM5.2 was 80% and 90%, respectively. Five cases were completely negative for AE1/AE3 and three for Cam5.2. Median overall survival for patients with stronger and weaker AE1/AE3 staining was 24.7 and 13.8 months, respectively (p=0.019). There was no difference in survival in relation to the CAM5.2 expression (p=0.44). In multivariate analysis adjusted for CAM5,2, T and N stage, gender and age at diagnosis, stronger AE1/AE3 expression was an independent predictor of increased survival (HR 0.50; 95% CI, 0.27-0.94; p=0.031).ConclusionHigh expression of AE1/AE3 is a favorable prognostic factor in surgically treated SCLC. The applicability of this finding to a typical patient population treated with non-surgical methods warrants further studies.
Effects of Orotic Acid-Induced Non-Alcoholic Fatty Liver on the Pharmacokinetics of Metoprolol and its Metabolites in Rats
Authors: Bang Won Seok , Hwang Ye Ran , Li Zhengri , Lee Inchul , Kang Hee Eun
Published: February 2019

Purpose: Preliminary study results have shown that rats with non-alcoholic fatty liver disease (NAFLD) induced by 1% orotic acid-containing diet have decreased hepatic CYP2D activity. This study aims to evaluate the possible pharmacokinetic changes in NAFLD as a result of reduced metabolic activity of CYP2D. Methods: The pharmacokinetics of metoprolol and its metabolites, O-desmethyl metoprolol (DMM) and α-hydroxy metoprolol (HM), was investigated in NAFLD and control rats following intravenous (1 mg/kg) and oral (2 mg/kg) administration of metoprolol. The hepatic CYP2D expression was also investigated. Results: NAFLD rats had lower CYP2D expression (by 36.6%) and slower intrinsic clearance (CLint) of metoprolol and formation of HM (by 40.1% and 37.2%, respectively). There were no significant changes in the pharmacokinetics of metoprolol and its metabolites following intravenous administration. In contrast, oral administration of metoprolol resulted in significantly increased total area under plasma concentration-time curve (AUC) of metoprolol (by 127%) and decreased metabolite formation ratios (AUCDMM/AUCMetoprolol [by 42.8%], AUCHM/AUCMetoprolol [by 35.0%]) in NAFLD rats. Moreover, these changes were well correlated with severity of steatosis as quantified by hepatic triglyceride contents. Conclusions: NALFD can lead to a reduction in the hepatic CLint of a drug if it is a substrate of the CYP2D subfamily. The decreased clearance may result in elevated drug concentrations and increased exposure.
Communities, universities and ethnicity: A conversation from Imagine: Connecting Communities Through Research
Authors: Brown Milton , Ward Paul
Published: February 2019

Imagine: Connecting Communities Through Research was a large five-year project in the Connected Communities programme using methodologies of co-production to explore imagining different futures with community groups. This article, which takes the form of a conversation, offers the perspectives
of two participants in Imagine to discuss how community organizations and communities work together and the impact of ethnic discrimination and disparity in universities. We set the conversation in the broader context of global discussions of knowledge production and power relationships. We
consider how universities, as large institutions, often create difficulties for smaller community organizations by focusing on their own interests. We address power and decision-making in Imagine, especially in relation to ethnicity. We seek to think about what needs to be done, both at strategic
levels in universities and on a personal level, to tilt the balance of benefit towards communities in collaborative relationships with higher education institutions.
HIGH-FREQUENCY ELECTROCORTICOGRAPHIC MARKER OF EPILEPTOGENIC ZONE
Authors: Arkhipova N. B. , Ulitin A. Yu. , Tastanbekov M. M. , Aleksandrov M. V.
Published: February 2019

Background. The search for new markers of the epileptogenic zone (EZ) for the surgical treatment of epilepsy is currently of relevance. Pathological high-frequency oscillations (pHFO) are considered to be a potential marker for EZ. Papers devoted to this topic are few and insufficiently systematized, mostly due to a small quantity of patients.Objective. This study was aimed to determine the diagnostic efficacy of high-frequency electrocorticography (HF ECoG) based on the epilepsy surgery outcomes.Design and methods. This is an original retrospective study of high-frequency bioelectrical activity parameters in 114 patients who underwent surgical treatment in the Polenov Neurosurgical Institute Clinic during 2017–2018. In the subgroup of patients with pharmacoresistant course of structural epilepsy (21 patients) on the preresective electrocorticogram, the pHFO index was higher than in the subgroup with intracerebral neoplasms (11 patients), which may be associated with a longer history and severity of the disease.Results. Through the analysis of the high-frequency component of the post-resective HF ECoG, it was shown that the presence or absence of pHFO in the range of 250–500 Hz does not affect the seizure outcome. The dynamics of the high-frequency activity index before and after the resection are statistically significant for the seizure outcome prediction for structural epilepsy surgery. In this study, the specificity of the pHFO dynamics analysis technique was 85.71 % and sensitivity equaled 58.33 %.Conclusion. Thus, the HF ECoG and the assessment of the dynamics of the pHFO index in the range of 250–500 Hz can complement the traditional method of intraoperative ECoG in the range of up to 70 Hz, including the prediction of the results of surgical treatment.
DECREASE IN ACTIVITY OF THE INFLAMMATORY PROCESS AFTER IMPLANTATION OF SILICONE WITH ADSORBED MULTIPOTENT STROMAL CELLS
Authors: Maiborodin I. V. , Mikheeva T. V. , Kuzkin S. A. , Kadyrova A. I. , Maiborodina V. I. , Shevela A. I.
Published: February 2019

Background. The wide spread of cellular technologies will sooner or later lead inevitably to the introduction of MMSC or their exosomes to patients who have implanted artificial materials in their organism. The engraftment of foreign bodies is accompanied first by acute and then chronic inflammation, very often acquiring a granulomatous character. A decrease in the activity of the inflammatory response can theoretically improve the results of implantation.Objective. To study the results of the influence of autologous MMSC of bone marrow origin (AMMSCBMO) adsorbed on silicone, on the inflammatory process that accompanies the implantation of this polymer in theexperiment. Design and methods. In different times, the condition of tissues around the implanted silicone with adsorbed AMMSCBMO was studied by method of light microscopy.

Results. After the implantation of silicone with adsorbed AMMSCBMO, as compared with the results of the introduction of this material without use of cellular technologies, a smaller volume of  loose fibrous connective tissue is formed around the encapsulated polymer. In this connective tissue after AMMSCBMO use the absolute number of all cells is lower in 2 weeks, and the percentage and numerical density of neutrophils — within 1–2 weeks. On the contrary, the relative number of erythrocytes within 1–2 weeks and macrophages at 1–3 weeks under the conditions of AMMSCBMO use were greater.Conclusion. A smaller volume of loose fibrous connective tissue and a decrease in the severity of cellular infiltration, in particular, the number of neutrophils, around the implanted silicone with  AMMSCBMO indicates a decrease in the activity of the inflammatory reaction as a result of the use of cellular technologies, more rapid cleansing of postoperative wound from debris, the success of reparative processes and the creation of conditions for the integration of a foreign bodies into the organism.
THE ROLE OF MDCT ANGOIGRAPHY IN THE DIAGNOSIS OF TAKAYASU ARTERITIS. CASE REPORT
Authors: Basek I. V. , Berezkina N. N.
Published: February 2019

Takayasu’s disease (non-specific aorto-arteritis) is a chronic, idiopathic, inflammatory disease that primarily affects large vessels, such as the aorta and its major branches, including the pulmonary and coronary arteries. It often develops in women under the age of 50 years. Accurate and early diagnosis plays an important role in the prognosis of life in patients with this pathology. Complaints of  patients with lesions of the aorta and its branches are non-specific in nature and are characterized by fever, night sweats, malaise and arthralgia, passing under the “mask” of other diseases. With the progression of the disease, stenoses or aneurysms occur in the arteries, which leads to ischemia of the limbs and internal organs, manifested by the corresponding clinical manifestations.The article presents the observation of aorto-arteritis Takayasu type V (generalized variant) in the woman of 26 years.
Development of a modeling tool for simulating electricity demand and on site PV power production in high time resolution: Applications in Costa Rica
Authors: Ruiz-Vásquez Sophia , Roldán Carlos , Cheng Vicky
Published: February 2019

Con el fin de apoyar de manera sostenible los múltiples sistemas de energía, las estrategiasde mejoramiento de sistemas de eficiencia energética implican la integración y aplicación deherramientas de análisis de energía urbanas. Los sistemas de energía, como la energía solarintermitente, requieren investigación sobre la capacidad de adaptación entre la demanda y laproducción. El análisis de coincidencia de energía requiere de fuentes de error mínimas, con elfin de obtener resultados más puntuales.En ciertas aplicaciones de simulación de energía, el intervalo de tiempo de uso común es deuna hora, sin embargo, estudios han demostrado que esto puede ser una fuente significativade error. Por ende, para la identificación del impacto que tiene la frecuencia temporal en lassimulaciones, se crearon modelos holísticos en alta resolución. Con estos modelos, se pretendela representación y obtención de resultados más precisos y exactos.El modelo de producción de energía fotovoltaica generada in-situ, se basa en un modelodesarrollado por el grupo de investigación Energy Effcient and Smart Cities (EESC). Datospertinentes, tales como la radiación incidente y la radiación global se obtuvieron del softwareMeteonorm. Para la elaboración del modelo de alta resolución de la demanda eléctricadoméstica, el modelo desarrollado por Centre for Renewable Energy Systems Technology ofLoughborough University, fue utilizado y modificado usando información pertinente de CostaRica.Estos modelos, implican módulos fotovoltaicos con producción energética in-situ y representanadecuadamente la demanda de electricidad doméstica. Por lo tanto, el cálculo de los análisisde la capacidad de adaptación de energía pudo ser efectuado. Dichos cálculos involucran losíndices OEF y OEM, que se refieren a la fracción de energía in situ y la coincidencia de energíaen las instalaciones, respectivamente. Mediante estos cálculos, se mostró que el uso de lasresoluciones más gruesas en el análisis de energía conduce a la sobreestimación, y a su vez elporcentaje de error incrementa.
Comparación de los métodos para la determinación de plaguicida residual en frutas y vegetales en India y Costa Rica
Authors: Mata Edgar , Robles Andrés , Mishra Dr. SukhDev , Sivaperumal Dr. P.
Published: February 2019

Este artículo corresponde a la comparación de los métodos seguidos para la determinaciónde plaguicida residual en frutas y vegetales tanto en India como en Costa Rica. Tanto enel National Institute of Occupational Health, Ahmedabad en India y el encargado de realizardicho proedimiento en Costa Rica, el Laboratorio del Servicio Fitosanitario del Estado, utilizanel procedimiento llamado QuEChERS.
The PCAOB Audit Quality Indicator Framework Project: Feedback From Stakeholders
Authors: Pinello Arianna S. , Volkan Ara G. , Franklin Justin , Levatino Michael , Tiernan Kimberlee
Published: February 2019

Audit Quality Indicators (AQIs), as defined by the Center for Audit Quality, include four different elements:firm leadership and tone at the top; engagement team knowledge, experience, and workload; monitoring; and auditor reporting. AQIs are quantitative and qualitative measures designed to improve audit quality and help audit committees select the best audit firm for their current needs. They are intended to increase the reliability and accuracy of financial reporting. The Public Company Accounting Oversight Board (PCAOB) has issued a concept release proposing twenty-eight potential AQIs for use in the United States. The PCAOB release describes the AQI reporting framework and asks for public opinion on whether or not it should be implemented. This study reviews the comment letters in response to PCAOB Docket 041,Concept Release on Audit Quality Indicators, and the AQI reporting frameworks currently in place in the United Kingdom, Singapore, and other countries. After reviewing the PCAOB’s proposed AQI framework, response letters to Docket 041, and the AQI frameworks used in other countries, this paper provides an opinion on how the PCAOB should proceed with the AQI framework initiative in the U.S. The analysis suggests that AQI reporting should not be mandated in the U.S., but should become a flexible and voluntary framework that provides valuable information, enhances transparency in the audit profession, and establishes a commitment to the improvement of audit quality.
Percepciones de los adolescentes trabajadores bolivianos sobre violencia física y psicológica mediante la técnica de grupos de discusión.
Authors: García Rodríguez Mara
Published: February 2019

The phenomenon of child and adolescent workers is complex due to its expansion, the existing family and communal disintegration, and its importance for the productive structure of the countries that suffer from it. In Potosí, these workers are an oppressed and vulnerable social group, and given the lack of competent educational programs and the negative concept these young people have about themselves, especially the girls, their culture is fundamentally macho. Change in the mentalities of these adolescents is remarkable when they are injected with a dose of self-esteem, autonomy, well-being, and consideration about the enjoyment of their rights and freedoms. The objective was to implement an affectivesexual health education program. Intervention in new generations from the educational field in non-violent conflict resolution is, in the medium and long run, one of the best resources to prevent all forms of violence.
PARP inhibitors in ovarian cancer treatment: more than a hope
Authors: Musella Angela , Marchetti Claudia , Panici Pierluigi Benedetti
Published: February 2019

No abstract available
Timing of medical therapy and surgery in liver metastatic colorectal cancer
Authors: Masi Gianluca , Ferrero Alessandro , Marino Donatella
Published: February 2019

No abstract available
Case 2 – Lack of response to trastuzumab in a patient with metastatic gastric cancer progressing after extended response to MET inhibitor therapy
Authors: Mori Elena , Baldi Giacomo Giulio , Scatizzi Marco , Castagnoli Antonio , Pugliese Lavinia , Di Fiore Giuseppe , Fargnoli Rossana , Laera Letizia , Di Donato Samantha , Daniele Bruno
Published: February 2019

In patients with advanced gastric cancer with high expression of HER2 protein, the addition of trastuzumab to chemotherapy significantly improves overall survival compared with chemotherapy alone in the first line setting. However, there are no data on anti-HER2 therapies beyond disease progression after first-line therapy. In many types of cancers, including gastric cancer, dysregulation of the receptor tyrosine kinase MET may lead to a more aggressive cancer phenotype and may be a negative prognostic indicator. Therapeutic targeting of MET/hepatocyte growth factor (HGF) signalling has used monoclonal antibodies and smallmolecule tyrosine kinase inhibitors (TKIs) against the MET receptor and its ligand, with several drugs in latephase clinical trials, including onartuzumab. Onartuzumab is a humanized monovalent monoclonal antibody directed against the hepatocyte growth factor receptor (c-Met). In advanced gastric cancer, the addition of onartuzumab to a standard chemotherapy regimen with oxaliplatin and fluoropyrimidine did not improve efficacy in gastric cancer patients in the overall study population or in those selected for positive MET status by immunohistochemistry. In this clinical case we observed a good clinical response to FOLFOX plus onartuzumab in a young patient with MET-positive gastric cancer. However, therapy with cisplatin, 5-fluorouracil and trastuzumab used after progression did not provide a benefit. This case report therefore highlights the importance of always fully identifying potential therapeutic targets in our patients in order to offer more personalized therapies. A correct molecular analysis is very important in deciding the therapeutic sequences in the metastatic setting.
Farklı Elma Çeşitleri Üzerine Asılan Tuzakların Tropinota hirta (Poda, 1761) (Coleoptera: Cetoniidae)’nın Yakalaması Üzerine Etkisi
Authors: YAŞAR Bülent , DAHHAM DAHHAM Omar Ali
Published: February 2019

Bu çalışmada; 2017-2018 yıllarında, Isparta ilinde
Red Chief, Williams Pride ve Braeburn elma çeşitlerinin çiçeklerinde beslenen Tropinota hirta’nın tuzaklarla
yakalanmasına, çeşitlerin etkisi ile tuzak asılan ve asılmayan ağaçlardaki
çiçeklerde zarar oranlarının karşılaştırılması amaçlanmıştır. Araştırmada, denemeler
beş tekerrürlü olarak gerçekleştirilmiştir. Çalışmada altında su bulunan açık
mavi renkli huni tuzakları ve çekici olarak da trans-sinnamil alkol ve anetol 1:1
oranında kullanılmıştır. Sonuçta; hem 2017 hem de 2018 yıllarında tüm çeşitler
için, tuzak asılmayan kontrollerdeki çiçek sayılarının, tuzak asılan
ağaçlardakilerden daha fazla olduğu saptanmıştır. Bunun nedeninin, ergin
böceklerin tuzaklardaki renk, su ve çekiciler ile ağaçlara doğru çekilmesi
sonucunda tuzak asılan ağaçların çiçeklerinde daha fazla zarara yol açması
olarak değerlendirilmiştir. Bu sonuçlar, tuzakların ağaçlardan daha uzağa
asılarak erginlerin yakalanmasının daha uygun bir yöntem olacağını ortaya
koymuştur. Çalışmada, 2017 yılında en fazla çiçek sayısına; Williams Pride,
daha sonra Braeburn ve diğerlerine göre daha az miktarda Red Chief çeşidi sahip
olmuştur. Benzer sonuçlar tuzak asılmayan ve sadece çiçekleri sayılan
çeşitlerde de elde edilmiştir. Çalışmanın 2018 yılında ise bu sıralama
değişerek en fazla çiçek sayısına Red Chief, daha sonra Braeburn ve en az çiçeğe
Williams Pride sahip olmuştur. Bunun nedeninin o yılın çiçek tomurcuğu
farklılaşmasının gerçekleşmesi ya da bir önceki yıldaki iklim koşullarının
etkili olduğu düşünülmektedir.
Web Usage Minning using Patterns with Different Algorithm
Authors:   Sobia Mehrban
Published: February 2019

Web usage mining is a part of data mining. Data usage mining is divided into three parts 1) Data content mining 2) Data structured mining 3) Data usage mining. In this paper I am discussing about log files which are used in data usage mining. Log files are used to store user’s activity in web server using websites. So that websites can be improved by gathering user data. Web usage mining having three sub parts which is reprocessing, data discovery and data analysis. Further, in this paper, details about web log files are discussed. Three algorithms are discussed which are used for patterns of log files. There comparison is showed in this paper with the help of graphs.
Software Project Management Observes: Fiasco V/S Victory
Authors:   Khizra Tabassum,   Shoaib Naseer
Published: February 2019

A study on successful and un-successful about 210 large software (development) projects from around the world between February 1995 and December 2017 has been presented in this review paper. All these projects involved on mass level that completed on time with their scheduled expense, and time frame estimates in development of those are getting late as defined, much expensive as decide, or were get delayed or close without its completion, major seven hurdles were noted: un sufficient project planning, un sufficient cost estimating, un sufficient measurements, un sufficient milestone tracking, un sufficient change control, and un sufficient -quality control, Poor Coronation and communication. After detail study on past reviews on these hurdles in project management, in this review paper we have presented a short overview of success and failure reasons/causes/possibilities of all those seven factor/ hurdles are noted. Maybe the clearest aspect of these major problems is linked with project management rather than technical resource. Two occupied ideas combine which are no proper excellence regulator are the huge funder for the rates, and late time and unfair plan organization have number of prospective reason of insufficient excellence actions.
A Review of Techniques for Optimizing Cache Energy Efficiency
Authors:   Hina Jilani,   Yasir Danial Khan
Published: February 2019

In today’s computer, there are larger sizes of the cache are using on the chip. Moreover, there is significant change has happened in the technology. Because of that change cache power efficiency has become the important issue in the processors. To solve this problem most of the researchers have proposed a different methodology to improve the cache energy efficiency. This paper review different techniques that are proposed for improving cache energy efficiency. There are different techniques discussed in this survey paper that is used to improve the cache energy at a different level of the cache. The main focus of the paper of survey is to urge the different researcher to propose different methodology so they can make the cache more efficient and energy saving.
Psychosocial Causes Affecting Inhalants Addiction in Children and Adolescents: Case Report
Authors: KARAASLAN Ayşenur
Published: February 2019

ABSTRACTApart from
industrial exposure, volatile agent exposure occurs to a significant extent by
abusing these substances with the aim of excitement. In recent years, inhalants addiction has rapidly spread among children and
adolescents. Indeed
children and adolescents’ use of substance may vary. Inhalants dependence is
generally seen at average 14-15 years of age in the patients. When
psychological reasons affecting volatile substance dependence are examined, it
can be said that factors such as not knowing how to cope with stress in
general, desire to get rid of negative and bad emotions, pleasure from matter,
pleasure, wanting to belong to a group and feeling strong.When social factors are taken into consideration, it is first and foremost
that access to volatile substances is easy and cheap, acceptance within the
family, peer influence, positive perspective on the substance in the social
environment and encouraging visuals in the social media

Here we present
a case of psychosocial factors that cause alcohol and cannabis addiction in his
family narrative, which begins to use volatile substance (lighter gas) at the
age of 12, in addition to inhalants, alcohol and cannabis.Key Words: Inhalants, substance addiction, psychosocial
causes
Hubungan Sikap Ibu dengan Pelaksanaan Metode Kangguru (Kangaroo Mother Care) pada Bayi Berat Badan Lahir Rendah di RS Siti Khodijah Sepanjang
Authors: Kusumawardani Paramitha Amelia , Cholifah Cholifah
Published: February 2019

Problems that often occur are setting the temperature that is still low and has a weak immune system and the process of forming the immune system that is not perfect so that the range of infection. Not all babies with a birth weight of less than 2,500 grams get health services using advanced technology because of financial constraints in care, geographical factors or areas of residence, transportation, and communication such as the use of incubators. The kangaroo treatment method is a method of contacting skin from skin (skin to skin) which is done directly by placing the baby on the mother's chest. The method of research carried out analytic research with a population of all mothers who have given birth either by normal or SC deliveries whose babies experience low body weight below less than 2500 grams (LBW) in SitiKhodijahSepanjang Hospital, which is the subject of research. Most of the mothers who had LBW babies had a positive attitude that was equal to 10 (66.7%) and most of the mothers carried out the kangaroo method correctly by 9 mothers (60%). This is also evidenced by the results of the Chi-Square test P = 0.005 <α = 0.05 so that H0 is rejected which means there is a relationship between the attitude of the mother and the implementation of the kangaroo method in low birth weight babies so that the community and health workers are expected to implement the kangaroo method infants low birth weight both health care and at home.