bluuebunny/crossref_metadata_2025 huggingface dataset:
Design-oriented dynamic model of deployable fin under time-varying elevated temperature environment
Authors: Ren H.Y. , Wang Y. , Wang L. , Zhou J.B. , Chang H.J. , Cai Y.P. , Lei B.
Published: August 2023

Coupling of clearance joint and harsh aerodynamic heating environment is an inevitable nonlinear factor in folding mechanism of the fin of high-speed aircrafts that remarkably modifies natural frequencies and modes of vibration from the initial design state. However, accurately predicting dynamic properties of deployable fin with full consideration of these effects is not common industry practice. A practical semi-analytical model based on Hertz contact theory and ESDU-78035 model is proposed in this study to investigate high-temperature connection stiffness of local hinged–locked mechanisms. Material property degradation and clearance variation caused by thermal expansion are comprehensively considered and quantified in this model. Vibration characteristics of the assembled deployable fin are then solved using finite element method (FEM). The real-time evolutionary process of thermal mode of the fin is discussed. And natural frequencies of fixed-value and time-varying connection stiffness are compared. The simulation results of this study demonstrate that the relative error of structure temperature between the sequential approach and fully coupled simulations is less than 6.98%. The connection stiffness (slope of the load-displacement curve) of the folding mechanism under high temperature conditions decreases by 3.52%, and the variation is mainly caused by the degradation of the elastic modulus of the material, while the clearance change due to the thermal expansion has no significant effect on the slope. The natural frequency of the deployable fin exhibits an inverse correlation with the temperature change trend, and the first three frequencies decrease by 1.67, 7.75, and 16.28 Hz compared to the initial value, respectively.
Federal Climate Policy Successes: Co-benefits, Business Acceptance, and Partisan Politics
Authors: Karapin Roger , Vogel David
Published: August 2023

While most literature on federal climate change policies has focused on failures to adopt broad policies, this article describes and explains successes in two important sectors. Regulations to improve the fuel economy of motor vehicles and efficiency standards for appliances and equipment have produced substantial reductions in greenhouse gas emissions, although they largely have other goals and hence can be considered implicit climate policies. We synthesize the existing literature with our analyses of case studies to offer three explanations for the adoption of effective policies in these two sectors. First, the policies delivered politically popular co-benefits, such as reducing consumers’ energy bills, enhancing energy security, and promoting public health. Second, they gained business acceptance because they were narrow in their scope, avoided long-term economic costs, and helped industry cope with state-level regulations; industry often strategically tried to influence these policies rather than resist them. Third, the legislation that initiated and expanded these policies received bipartisan support, which was aided by co-benefits and business acceptance; more recently, these laws have been strengthened through the actions of Democratic administrations. We conclude by comparing these policy areas to the passage of the Inflation Reduction Act of 2022.
Trans Women, Cis Women, Alien Women, and Robot Women Are Women: They Are All (Simply) Adults Gendered Female
Authors: Arvan Marcus
Published: August 2023

Alex Byrne contends that women are (simply) adult human females, claiming that this thesis has considerably greater initial appeal than the justified true belief (JTB) theory of knowledge. This article refutes Byrne's thesis in the same way the JTB theory of knowledge is widely thought to have been refuted: through simple counterexamples. Lessons are drawn. One lesson is that women need not be human. A second lesson is that biology and physical phenotypes are both irrelevant to whether someone is a woman, and indeed, female in a gendered sense. A third lesson is that trans women, cis women, alien women, and robot women are all women because to be a woman is to be an adult gendered female. This article does not purport to settle complex normative questions of ethics or justice, including whether the ordinary meaning of woman ought to be retained or changed—though I do note plausible implications for these debates. This article does purport to settle what the ordinary meaning of woman is, and in that regard contribute to important conceptual ground-clearing regarding what constitutes an ameliorative or revisionary definition of woman.
Optimal two-dimensional roughness for transition delay in high-speed boundary layer
Authors: Jahanbakhshi Reza , Zaki Tamer A.
Published: August 2023

The influence of surface roughness on transition to turbulence in a Mach 4.5 boundary layer is studied using direct numerical simulations. Transition is initiated by the nonlinearly most dangerous inflow disturbance, which causes the earliest possible breakdown on a flat plate for the prescribed inflow energy and Mach number. This disturbance primarily comprises two normal second-mode instability waves and an oblique first mode. When localized roughness is introduced, its shape and location relative to the synchronization points of the inflow waves are confirmed to have a clear impact on the amplification of the second-mode instabilities. The change in modal amplification coincides with the change in the height of the near-wall region where the instability wave speed is supersonic relative to the mean flow; the net effect of a protruding roughness is destabilizing when placed upstream of the synchronization point and stabilizing when placed downstream. Assessment of the effect of the roughness location is followed by an optimization of the roughness height, abruptness and width with the objective of achieving maximum transition delay. The optimization is performed using an ensemble-variational (EnVar) approach, while the location of the roughness is fixed upstream of the synchronization points of the two second-mode waves. The optimal roughness disrupts the phase of the near-wall pressure waves, suppresses the amplification of the primary instability waves and mitigates the nonlinear interactions that lead to breakdown to turbulence. The outcome is a sustained non-turbulent flow throughout the computational domain.
Leadership by cavea: The social processes of interorganisational collaborative leadership
Authors: North-Samardzic Andrea , Kan Melanie , Edwards Gareth
Published: August 2023

Research on interorganisational collaboration is longstanding however the role leadership plays in such collaborations is often neglected. Using grounded theory, we present a process model of ‘leadership by cavea’ whereby the relationships across organisations involved in a collaborative project were structured according to hierarchies of privilege, determined by the inherent power of ‘bonding’ social capital. While it emerged that cultural capital was a more valuable resource, this was recognised too late in the leadership process for it to make a necessary contribution. Our findings demonstrate that when seeking to practice collaborative leadership across organisations, individuals and the organisations they represent must be aware of the power they hold and wield, even needing to share or relinquish power to ensure that hierarchies of privilege do not hinder efforts to achieve mutual goals.
Geothermal heat flow from borehole measurements at the margin of Princess Elizabeth Land (East Antarctic Ice Sheet)
Authors: Talalay Pavel G. , Gong Da , Fan Xiaopeng , Li Yazhou , Leitchenkov German , Li Bing , Zhang Nan , Wang Rusheng , Yang Yang , Hong Jialin
Published: August 2023

A 198.8 m deep borehole was drilled through ice to subglacial bedrock in the northwestern marginal part of Princess Elizabeth Land, ~12 km south of Zhongshan Station, in January–February 2019. Three years later, in February 2022, the borehole temperature profile was measured, and the geothermal heat flow (GHF) was estimated using a 1-D time-dependent energy-balance equation. For a depth corresponding to the base of the ice sheet, the GHF was calculated as 72.6 ± 2.3 mW m−2and temperature −4.53 ± 0.27°C. The regional averages estimated for this area based, generally, on tectonic setting vary from 55 to 66 mW m−2. A higher GHF is interpreted to originate mostly from the occurrence of metamorphic complexes intruded by heat-producing elements in the subglacial bedrock below the drill site.
MIGRATIONS AND CULTURAL EVOLUTION IN THE LIGHT OF RADIOCARBON DATING OF BRONZE AGE SITES IN THE SOUTHERN URALS
Authors: Epimakhov Andrey , Zazovskaya Elya , Alaeva Irina
Published: August 2023

This research aims to contribute to our knowledge of the chronology of the main cultural entities of the Bronze Age in the Southern Urals. The objectives of this work include the verification of earlier conclusions regarding individual sites, expanding the date series for the key cultures with reliable dates, and creating reference series for the Bayesian modeling of key archaeological sites. Thirty-two samples were selected from reliable contexts. They reflect seven different cultural traditions of the 2nd millennium calBC (Sintashta, Srubnaya, Alakul, Fedorovka, Cherkaskul, Final Bronze Age1, Transition to Early Iron Age2). Collagen (human and domestic animal bones), charcoal, and wood samples were used for radiocarbon dating. Pairs of different-type samples (human bone – animal bone, animal bone – charcoal) were obtained for the same undisturbed burial and the building floor at the time of its abandonment. The data and the composition of δ15N and δ13C isotopes allow the new dates to be considered reliable. Furthermore, the new results do not conflict with the previously obtained accelerator mass spectrometry (AMS) dates. Determining boundary intervals for the main cultures of the Andronovo cultural community (Alakul and Fedorovka) resulted in statistically reliable conclusions on their relationship. The Alakul culture appeared earlier than the Fedorovka culture. The latter has a migratory origin in the Southern Urals. The two traditions have a long history of interaction, but the Alakul culture ending earlier. The series of dates for the Final Bronze Age, divided into two sub-periods, has been significantly expanded. Bayesian modeling of the chronology of the stratified settlement Sintashta II (Levoberezhnoe) made it possible to determine the intervals of the main phases of its history: 2004–1852 calBC (Sintashta culture) and 1410–1170 calBC (Final Bronze Age). Intermediate Cherkaskul phase is represented by a single date (1731–1541 cal BC).
Transformations: the material representation of historical experiments in science teaching
Authors: Heering Peter
Published: August 2023

Some experiments from the history of physics became so famous that they not only made it into the textbook canon but were transformed into lecture demonstration performances and student laboratory activities in the nineteenth and twentieth centuries. While, at first glance, some of these demonstrations as well as the related instruments do resemble their historical ancestors, a closer examination reveals significant differences both in the instruments themselves and in the practices and meanings associated with them. In this paper, I analyse the relation between the research instruments and the respective teaching demonstrations. In doing so, I particularly distinguish between demonstrations that address the process of the actual experimental procedures, and those that focus on the outcome or results (the product) of the experiment. This distinction will be illustrated in some exemplary case studies from the late nineteenth century and the early twentieth in which both the historical experiment and the related educational devices are analysed. The tension between the historical experiment on the one hand, and the different variants of the teaching version on the other, result in the educational as well as epistemological problems that are discussed in this paper.
Composition and diversity of bacterial communities associated with honey bee foragers from two contrasting environments
Authors: Lazarova Stela , Lozanova Lyudmila , Neov Boyko , Shumkova Rositsa , Balkanska Ralitsa , Palova Nadezhda , Salkova Delka , Radoslavov Georgi , Hristov Peter
Published: August 2023

The honey bee is associated with a diverse community of microbes (viruses, bacteria, fungi, and protists), commonly known as the microbiome. Here, we present data on honey bee microbiota from two localities having different surrounding landscapes – mountain (the Rhodope Mountains) and lowland (the Danube plain). The bacterial communities of abdomen of adult bees were studied using amplicon sequencing of the 16S rRNA gene. The composition and dominance structure and their variability within and between localities, alpha and beta diversity, and core and differential taxa were compared at different hierarchical levels (operational taxonomic units to phylum). Seven genera (Lactobacillus, Gilliamella, Bifidobacterium, Commensalibacter, Bartonella, Snodgrassella, and Frischella), known to include core gut-associated phylotypes or species clusters, dominated (92–100%) the bacterial assemblages. Significant variations were found in taxa distribution across both geographical regions and within each apiary. Lactobacillus (Firmicutes) prevailed significantly in the mountain locality followed by Gilliamella and Bartonella (Proteobacteria). Bacteria of four genera, core (Bartonella and Lactobacillus) and non-core (Pseudomonas and Morganella), dominated the bee-associated assemblages of the Danube plain locality. Several ubiquitous bacterial genera (e.g., Klebsiella, Serratia, and Providencia), some species known also as potential and opportunistic bee pathogens, had been found in the lowland locality. Beta diversity analyses confirmed the observed differences in the bacterial communities from both localities. The occurrence of non-core taxa contributes substantially to higher microbial richness and diversity in bees from the Danube plain locality. We assume that the observed differences in the microbiota of honey bees from both apiaries are due to a combination of factors specific for each region. The surrounding landscape features of both localities and related vegetation, anthropogenic impact and land use intensity, the beekeeping management practices, and bee health status might all contribute to observed differences in bee microbiota traits.
On the density of bounded bases
Authors: Fang Jin-Hui
Published: August 2023

For a nonempty set A of integers and an integer n, let $r_{A}(n)$ be the number of representations of n in the form $n=a+a'$, where $a\leqslant a'$ and $a, a'\in A$, and $d_{A}(n)$ be the number of representations of n in the form $n=a-a'$, where $a, a'\in A$. The binary support of a positive integer n is defined as the subset S(n) of nonnegative integers consisting of the exponents in the binary expansion of n, i.e., $n=\sum_{i\in S(n)} 2^i$, $S(-n)=-S(n)$ and $S(0)=\emptyset$. For real number x, let $A(-x,x)$ be the number of elements $a\in A$ with $-x\leqslant a\leqslant x$. The famous Erdős-Turán Conjecture states that if A is a set of positive integers such that $r_A(n)\geqslant 1$ for all sufficiently large n, then $\limsup_{n\rightarrow\infty}r_A(n)=\infty$. In 2004, Nešetřil and Serra initially introduced the notation of “bounded” property and confirmed the Erdős-Turán conjecture for a class of bounded bases. They also proved that, there exists a set A of integers satisfying $r_A(n)=1$ for all integers n and $|S(x)\bigcup S(y)|\leqslant 4|S(x+y)|$ for $x,y\in A$. On the other hand, Nathanson proved that there exists a set A of integers such that $r_A(n)=1$ for all integers n and $2\log x/\log 5+c_1\leqslant A(-x,x)\leqslant 2\log x/\log 3+c_2$ for all $x\geqslant 1$, where $c_1,c_2$ are absolute constants. In this paper, following these results, we prove that, there exists a set A of integers such that: $r_A(n)=1$ for all integers n and $d_A(n)=1$ for all positive integers n, $|S(x)\bigcup S(y)|\leqslant 4|S(x+y)|$ for $x,y\in A$ and $A(-x,x) \gt (4/\log 5)\log\log x+c$ for all $x\geqslant 1$, where c is an absolute constant. Furthermore, we also construct a family of arbitrarily spare such sets A.
Well-being and the Problem of Unstable Desires
Authors: Mariqueo-Russell Atus
Published: August 2023

This paper considers a new problem for desire theories of well-being. The problem claims that these theories are implausible because they misvalue the effects of fleeting desires, long-standing desires, and fluctuations in desire strength on well-being. I begin by investigating a version of the desire theory of well-being, simple concurrentism, that fails to capture intuitions in these cases. I then argue that desire theories of well-being that are suitably stability-adjusted can avoid this problem. These theories claim that the average strength of a desire, and the length of time that it is held, both influence the extent to which its fulfilment or frustration affects well-being. I end by considering whether value-fulfilment theories of well-being have a more attractive response to this problem. I find that these theories have significant downsides that make them unappealing alternatives.
Why do we say them when we know it should be they? Twitter as a resource for investigating nonstandard syntactic variation in The Netherlands
Authors: Grondelaers Stefan , van Hout Roeland , van Halteren Hans , Veerbeek Esther
Published: August 2023

Two Twitter-based corpus studies are reported to account for the increasing preference in The Netherlands for the stigmatized subject use of the object pronoun hun ‘them.’ Twitter data were collected to obtain a sufficient number of hun-tokens, but also to investigate the validity of two hypotheses on the preference for hun, this is, that subject-hun is a contrast profiler which thrives in contexts of evaluation and qualification, and that subject-hun is propelled by its dynamic social meaning, being a tool for nonposh and streetwise self-stylization. Although the latter is not normally a predictor included in regression analyses of constructional choice, it turns out that expressively spruced up tweets with vivid contrast profiling are the prime biotope of subject-hun. Along the way, this paper reviews the potential of Twitter data for the reconciliation of macro-big-data analysis with micro-sociolinguistic focus, but it also reports and attempts to remedy three concerns.
Mobile Medical Teams are Often Over-Qualified
Authors: Van Biesen Sofie-An , Devue Katleen , Van Laere Sven , De Leeuw Kathleen , Hubloue Ives , Bierens Joost
Published: August 2023

Background and Importance:

Emergency department (ED) staff in Belgium is simultaneously involved in patient care in the ED and in prehospital interventions as part of a Mobile Medical Team (MMT) or a Paramedic Intervention Team (PIT). There is a growing concern that the MMT is often over-qualified for the prehospital interventions they are dispatched to, while their absence from the ED results in insufficient human resources there.

Objective:

The current study aims to investigate whether this perception is correct in the EDs of two different regions, while also examining the differences between a two-tiered (2T) and a three-tiered (3T) Emergency Medical Services (EMS) region.

Methods:

A specially developed and pre-tested registration form was completed by physicians and nurses before and after each MMT intervention. The form included information on the composition of the MMT, the perceived need for MMT intervention pre-departure from the ED, the subjective appreciation of the need for the MMT after an intervention, and the therapeutic intervention(s) performed, in order to obtain a more objective appreciation of the actual need for an MMT. Data from a 2T and a 3T region were analyzed to rate the appropriateness of the interventions.

Results:

Although the 2T and 3T regions showed differences regarding MMT composition, dispatching, and logistics, the outcome of the study was identical in both regions. Before the intervention, physicians and nurses estimated that the MMT intervention would not be necessary in 37.7% of cases. However, following the intervention, it was subjectively deemed unnecessary in 65.7% of cases. Based on therapeutic interventions performed, the MMT was viewed as being over-qualified for carrying these out in 85.6% of cases. Post-intervention, the initial prediction that the MMT was over-qualified for the call was confirmed by the same physicians and nurses in 87.6% of cases, whilst their prediction was correct in 92.8% of cases in terms of the intervention that was carried out.

Conclusion:

In two different Belgian regions, the MMT is over-qualified in a vast majority of interventions. Physicians and nurses within the MMT can generally already predict that the MMT is over-qualified when leaving the ED. These findings suggest that there may be significant opportunities to improve the efficacy of human resources in the ED once there are less interventions carried out by an over-qualified MMT.
Participation in the Georgia Food for Health programme and CVD risk factors: a longitudinal observational study
Authors: Cook Miranda Alonna , Taylor Kathy , Reasoner Tammy , Moore Sarah , Mooney Katie , Tran Cecilia , Barbo Carli , Schmidt Stacie , Stein Aryeh D , Webb Girard Amy
Published: August 2023

Objective:

To assess the relationship between programme attendance in a produce prescription (PRx) programme and changes in cardiovascular risk factors.

Design:

The Georgia Food for Health (GF4H) programme provided six monthly nutrition education sessions, six weekly cooking classes and weekly produce vouchers. Participants became programme graduates attending at least 4 of the 6 of both the weekly cooking classes and monthly education sessions. We used a longitudinal, single-arm approach to estimate the association between the number of monthly programme visits attended and changes in health indicators.

Setting:

GF4H was implemented in partnership with a large safety-net health system in Atlanta, GA.

Participants:

Three hundred thirty-one participants living with or at-risk of chronic disease and food insecurity were recruited from primary care clinics. Over three years, 282 participants graduated from the programme.

Results:

After adjusting for programme site, year, participant sex, age, race and ethnicity, Supplemental Nutrition Assistance Program participation and household size, we estimated that each additional programme visit attended beyond four visits was associated with a 0·06 kg/m2 reduction in BMI (95 % CI –0·12, –0·01; P = 0·02), a 0·37 inch reduction in waist circumference (95 % CI –0·48, –0·27; P < 0·001), a 1·01 mmHg reduction in systolic blood pressure (95 % CI –1·45, –0·57; P < 0·001) and a 0·43 mmHg reduction in diastolic blood pressure (95 % CI –0·69, –0·17; P = 0·001).

Conclusions:

Each additional cooking and nutrition education visit attended beyond the graduation threshold was associated with modest but significant improvements in CVD risk factors, suggesting that increased engagement in educational components of a PRx programme improves health outcomes.
Jesuits as Petitioners: Antonio Ruiz de Montoya and the Issue of Indigenous Slavery in the Early Seventeenth-Century South Atlantic
Authors: Lopes de Carvalho Francismar Alex
Published: August 2023

In the Spanish monarchy, corporations, religious orders, and other petitioners kept procurators in Madrid to lobby the royal councils on their behalf. Drawing on an efficient network of information, the Madrid-based Jesuit procurators were known for their insistence on solving the financial and personnel needs of several missions throughout the New World. This article analyzes a series of petitions composed by Antonio Ruiz de Montoya in the late 1630s on behalf of Jesuit missions in Paraguay. These missions had been harassed by Portuguese slavers, who captured tens of thousands of natives in this region. Ruiz de Montoya's petitions reveal that the Jesuits’ lobbying actions had a much greater impact than has been assumed. Far from confining themselves to asking for material and human resources for the missions, the Jesuits proposed that the Spanish crown make a large-scale intervention in the administration of Portuguese domains in the South Atlantic, a program that Madrid would have implemented were it not for Portuguese independence in 1640.
Why Indigenous Slavery Continued in Spanish America after the New Laws of 1542
Authors: van Deusen Nancy E.
Published: August 2023

A prevailing idea in the scholarly literature is that the New Laws of 1542 outlawed the enslavement of indios (Indigenous people of the Spanish Indies, a category invented by Europeans) in Spanish America. Many see the enactment of this legislation as emblematic of the Spanish crown's exertion of imperial authority over the conquerors who had caused irreparable damage to the Indigenous peoples of the Americas. This article contests this prevailing narrative. It explores how and why the Council of the Indies (the governing council of the Spanish possessions, reporting directly to the king), the Spanish king, and viceroys (or audiencias with viceregal approval) mandated Indigenous slavery for life or for a temporary period. Mandates affected at least 15 Indigenous groups in at least ten locations throughout the Spanish-occupied Western Hemisphere in the seven decades following the passage of the New Laws. I focus on this period to explain the conditions, rationales, legal channels, and procedures used by vassals and local and imperial authorities to authorize the enslavement of targeted Indigenous peoples.
Performance of the WRF Model at the Convection‐Permitting Scale in Simulating Snowfall and Lake‐Effect Snow Over the Tibetan Plateau
Authors: Lin Qian , Chen Jie , Ou Tinghai , Lai Hui‐Wen , Prein Andreas F. , Chen Deliang
Published: August 2023

This study investigated the performance of the Weather Research Forecasting (WRF) model at 4‐km horizontal grid spacing in simulating precipitation, 2 m air temperature (T2), snowfall, and lake‐effect snow (October 4–8, 2018) over the Tibetan Plateau (TP). Multiple simulations with different physical parameterization schemes (PPSs), including two planetary boundary layer schemes (Yonsei University and Mellor–Yamada–Janjic), no cumulus and multi‐scale Kain‐Fritsch, two land surface models (Noah and Noah‐MP), and two microphysics schemes (Thompson and Milbrandt), were conducted and compared. Compared with gauge observations, all PPSs simulate mean daily precipitation with mean relative errors (MREs) of 27.7%–53.6%. Besides, spatial correlation coefficients (SCCs) between simulated and observed mean daily precipitation range from 0.56 to 0.71. For simulations of T2, all PPSs perform similarly well, even though the mean cold biases are up to about 3°C. Meanwhile, all PPSs exhibit acceptable performance in simulating spatial distributions of snow depth, snow cover, and snowfall amount, with SCCs of 0.37–0.65 between simulations and observations. However, the WRF simulations significantly overestimate snow depth (∼0.4 cm mean error) and snowfall amount (MREs >372%). The Milbrandt scheme slightly outperforms the other PPSs in simulating snow‐related variable magnitudes. Due to their inaccurate temperature and airflow modeling over the lake surface and its surroundings, none of the WRF simulations well reproduce the characteristics that more snow occurs over the lake and downwind area. Overall, this study provides a useful reference for future convection‐permitting climate modeling of snow or other extreme events when using the WRF model in the TP and other alpine regions.
Scale‐Dependent Estimability of Turbulent Flux in the Unstable Surface Layer for Land Surface Modeling
Authors: Liu Shaofeng , Zeng Xubin , Dai Yongjiu , Yuan Hua , Wei Nan , Wei Zhongwang , Lu Xingjie , Zhang Shupeng , Li Xian‐Xiang
Published: August 2023

Surface flux estimation is essential to land surface modeling in earth system models. In practice, parameterizations of surface turbulent fluxes are almost all based on the similarity theory. That is, the grid or subgrid mean surface‐layer flow is assumed at equilibrium with the underlying earth surface, and therefore some empirical relations can be used to estimate surface fluxes. In this paper, scale‐dependent estimability of turbulent flux in the unstable surface layer is systematically investigated based on high‐resolution large‐eddy simulation data over a flat and homogeneous domain, representing a typical land surface modeling grid. It is found that turbulent flow in the unstable surface layer inherently fluctuates over a wide range of scales. This kind of fluctuation affects the steady‐state relations between mean atmospheric quantities and underlying earth surface, and hence affects the estimability of surface fluxes. Sensitivity tests show that the relative root mean square error of the estimated surface friction velocity for a subdomain generally increases as the subdomain becomes smaller. The error can be as high as 35% as the subdomain size decreases to the order of the surface layer height. To achieve an error of 10% for all cases, the subdomain size should be at least on the order of the boundary layer height. These findings imply that estimability‐based strategies may be needed for representing subgrid heterogeneity for surface flux estimation in land surface modeling.
Optimizing Ocean Bottom Seismometers for Shallow Water Using Shielding and Horizontal Pressure Gradient Data
Authors: Webb Spahr C. , Barclay Andrew H.
Published: August 2023

We show large “shields” can significantly reduce horizontal component noise levels for ocean bottom seismometers by shielding the seismic sensors from shaking due to ocean currents. However, at short period (<1 s) some noise from vibration or rocking of the shield under current can partly couple through the ground causing peaks in the noise spectra. Deformation of the seafloor under ocean wave loading (“compliance”) raises noise levels at long period (>5 s) for both vertical and horizontal components at shallow water sites. Pressure gauge data is now routinely used to predict and remove this source of noise on vertical component data. We have developed horizontal pressure gradient (HPG) gauges to measure and remove this source of noise from horizontal component data. The combination of HPG data and shielding enables low noise long period seismic observations at otherwise very noisy shallow seafloor sites.
Compounding of Sea‐Level Processes During High‐Tide Flooding Along the U.S. Coastline
Authors: Li Sida , Wahl Thomas , Piecuch Christopher , Dangendorf Sönke , Thompson Philip , Enríquez Alejandra , Liu Lintao
Published: August 2023

High‐tide flooding (HTF) is usually generated by a variety of different processes acting at different temporal scales across different geographic regions, but little is known about the role of interactions between those. We assess the role of compounding effects arising from cross‐covariances between different sea‐level components in generating HTF events along the US coastline. Our results show that compounding effects contribute to both HTF frequencies and magnitudes. The US Gulf and northwest coasts exhibit particularly high potential for compound HTF. Long‐term sea‐level rise is the main driver of accelerated HTF frequencies along the US coastline. However, even in the absence of sea‐level rise, changes in compounding effects due to increased or decreased cross‐covariances between sea‐level components associated with climate variability and change also modulate compound HTF. Our results highlight the importance of adequately modeling compounding effects between sea‐level components when generating future projections of HTF.
Antarctic Bottom Water in the Vema Fracture Zone
Authors: Morozov E. G. , Frey D. I. , Zuev O. A. , Makarenko N. I. , Seliverstova A. M. , Mekhova O. S. , Krechik V. A.
Published: August 2023

A section of 46 CTD/Lowered Acoustic Doppler Current Profiler stations along the Vema Fracture Zone (VFZ) was made for the first time with a repeat of the transverse section on the main sill (at 41° W) for the sixth time. Potential temperature of Antarctic Bottom Water when it flows into the fracture increases from 1.3°С to 1.6°C. This temperature increase is much smaller than in the Romanche Fracture Zone because in the VFZ there are not many transverse sills that force the flow to become turbulent. A zone with minimal velocities of the bottom flows exists in the western part of the VFZ up to the main sill. A current with velocities of 0.25 m/s flows above the low velocity zone at a depth of about 4,000 m. Underwater spillways with hydraulically controlled flow of bottom water down the slope from 4,500 m to 5,000 m at speeds up to 0.40 m/s were found east of the sill (in the central and southern channels). The bottom current accelerates as it flows down, but then its kinetic energy decreases. The bottom current slows down and mixes with surrounding waters. A thin (∼30 m) bottom flow descends further to the deep depression. In the southern channel of the VFZ, bottom water flows into a deep (5,400 m) basin. The coldest and densest water reaches this depression during rare inflows.
Large‐Scale Circulation Context for North American West Coast Atmospheric Rivers: Influence of the Subseasonal NPO/WP Teleconnection
Authors: Hicks Justin , Guan Bin , Nigam Sumant , Ruiz‐Barradas Alfredo
Published: August 2023

Understanding the variability of atmospheric rivers (ARs) on subseasonal time scales is pivotal for efficient water resource management along the west coast of North America. ARs during 1980–2018 based on the Modern‐Era Retrospective analysis for Research and Applications, version 2 are analyzed to quantify the modulation of winter (December–February) landfalling ARs in the western US by leading subseasonal teleconnections, focusing on pentad evolution rather than seasonal‐mean patterns. The growth phase of the North Pacific Oscillation/West Pacific (NPO/WP) teleconnection—the second leading pattern in 200‐hPa geopotential heights in boreal winter—is found to be particularly influential in modulating the number of landfalling ARs in this region. In the positive phase of NPO/WP growth, the presence of anomalous low pressure centered just south of Alaska (i.e., a strengthening of the Aleutian Low) and anomalous high pressure around Hawaii results in moisture convergence in the central and eastern Pacific, bringing southwesterly moisture fluxes to the coast and inland. The modulation by NPO/WP is stronger than by commonly‐considered climate variability modes, such as the Pacific/North American (PNA) pattern. Although southwesterly fluxes are stronger over the Pacific Ocean during the positive phase of PNA, they tend to transition to southerly fluxes before extending inland, resulting in smaller overland impacts in the western US. The analysis of temporal evolutions indicates AR activity peaks 5 days after the mature phase of NPO/WP growth, as in the case of PNA. Overall, the study suggests potential subseasonal predictability of US West Coast ARs from incipient‐phase knowledge of the leading teleconnection patterns, especially the NPO/WP.
Comprehensive analyses of circulating cardiometabolic proteins and objective measures of fat mass
Authors: Titova Olga E. , Brunius Carl , Warensjö Lemming Eva , Stattin Karl , Baron John A. , Byberg Liisa , Michaëlsson Karl , Larsson Susanna C.
Published: August 2023

Background

The underlying molecular pathways for the effect of excess fat mass on cardiometabolic diseases is not well understood. Since body mass index is a suboptimal measure of body fat content, we investigated the relationship of fat mass measured by dual-energy X-ray absorptiometry with circulating cardiometabolic proteins.

Methods

We used data from a population-based cohort of 4950 Swedish women (55–85 years), divided into discovery and replication samples; 276 proteins were assessed with three Olink Proseek Multiplex panels. We used random forest to identify the most relevant biomarker candidates related to fat mass index (FMI), multivariable linear regression to further investigate the associations between FMI characteristics and circulating proteins adjusted for potential confounders, and principal component analysis (PCA) for the detection of common covariance patterns among the proteins.

Results

Total FMI was associated with 66 proteins following adjustment for multiple testing in discovery and replication multivariable analyses. Five proteins not previously associated with body size were associated with either lower FMI (calsyntenin-2 (CLSTN2), kallikrein-10 (KLK10)), or higher FMI (scavenger receptor cysteine-rich domain-containing group B protein (SSC4D), trem-like transcript 2 protein (TLT-2), and interleukin-6 receptor subunit alpha (IL-6RA)). PCA provided an efficient summary of the main variation in FMI-related circulating proteins involved in glucose and lipid metabolism, appetite regulation, adipocyte differentiation, immune response and inflammation. Similar patterns were observed for regional fat mass measures.

Conclusions

This is the first large study showing associations between fat mass and circulating cardiometabolic proteins. Proteins not previously linked to body size are implicated in modulation of postsynaptic signals, inflammation, and carcinogenesis.
Human norovirus (HuNoV) GII RNA in wastewater solids at 145 United States wastewater treatment plants: comparison to positivity rates of clinical specimens and modeled estimates of HuNoV GII shedders
Authors: Boehm Alexandria B. , Wolfe Marlene K. , White Bradley J. , Hughes Bridgette , Duong Dorothea , Banaei Niaz , Bidwell Amanda
Published: August 2023

Background

Human norovirus (HuNoV) is a leading cause of disease globally, yet actual incidence is unknown. HuNoV infections are not reportable in the United States, and surveillance is limited to tracking severe illnesses or outbreaks. Wastewater monitoring for HuNoV has been done previously and results indicate it is present in wastewater influent and concentrations are associated with HuNoV infections in the communities contributing to wastewater. However, work has mostly been limited to monthly samples of liquid wastewater at one or a few wastewater treatment plants (WWTPs).

Objective

The objectives of this study are to investigate whether HuNoV GII preferentially adsorbs to wastewater solids, investigate concentrations of HuNoV GII in wastewater solids in wastewater treatment plants across the county, and explore how those relate to clinical measures of disease occurrence. In addition, we aim to develop and apply a mass-balance model that predicts the fraction of individuals shedding HuNoV in their stool based on measured concentrations in wastewater solids.

Methods

We measured HuNoV GII RNA in matched wastewater solids and liquid influent in 7 samples from a WWTP. We also applied the HuNoV GII assay to measure viral RNA in over 6000 wastewater solids samples from 145 WWTPs from across the United States daily to three times per week for up to five months. Measurements were made using digital droplet RT-PCR.

Results

HuNoV GII RNA preferentially adsorbs to wastewater solids where it is present at 1000 times the concentration in influent. Concentrations of HuNoV GII RNA correlate positively with clinical HuNoV positivity rates. Model output of the fraction of individuals shedding HuNoV is variable and uncertain, but consistent with indirect estimates of symptomatic HuNoV infections in the United States.

Impact statement

Illness caused by HuNoV is not reportable in the United States so there is limited data on disease occurrence. Wastewater monitoring can provide information about the community spread of HuNoV. Data from wastewater can be available within 24 h of sample receipt at a laboratory. Wastewater is agnostic to whether individuals seek medical care, are symptomatic, and the severity of illness. Knowledge gleaned from wastewater may be used by public health professionals to make recommendations on hand washing, surface disinfection, or other behaviors to reduce transmission of HuNoV, or medical doctors to inform clinical decision making.
Constructing origami power generator from one piece of electret thin film and application in AI-enabled transmission line vibration monitoring
Authors: Lyu Boming , Zhou Huipeng , Gao Yangyang , Mao Xinhui , Li Fangzhi , Zhang Jiyuan , Nie Dezhi , Zeng Wen , Lu Yonglin , Wu Jin , Yang Zhaoshu , Tao Kai
Published: August 2023

One of the crucial issues for applying electret/triboelectric power generators in the Internet of Things (IoT) is to take full advantage of specific high voltage signals and enable self-powered sensing. Therefore, inspired by Miura-origami, we present an innovative origami power generator (OPG) constructed from only one piece of electret thin film. The Miura-origami architecture realizes a generator with excellent deformability and stretchability and makes it unnecessary for any auxiliary support structure during the compress-release cycle. Various parameters of the generator are intensively investigated, including the excitation accelerations, excitation displacements, numbers of power generation units and deformation degree of the device. When stimulated with 5.0 g acceleration at 15 Hz frequency, the generator with 8 generation units can obtain an instantaneous peak-to-peak voltage and a remarkable optimum peak power of 328 V and 2152 μW at 50 MΩ, respectively. In addition, the regulable shape and multiple generation modes of the device greatly improve its applicability in various vibration energy collection requirements. Based on the above results, a hexagonal electret generator integrated with six-phase OPGs is developed as a “Buoy on Sky,” after which the signal waveforms generated from internal power generators are recognized with 92% accuracy through a neural network algorithm that identifies the vibration conditions of transmission lines. This work demonstrates that a fusion of origami art and energy conversion techniques can achieve a multifunctional generator design satisfying the requirements for IoT applications.
PG545 sensitizes ovarian cancer cells to PARP inhibitors through modulation of RAD51-DEK interaction
Authors: Ray Upasana , Thirusangu Prabhu , Jin Ling , Xiao Yinan , Pathoulas Christopher L. , Staub Julie , Erskine Courtney L. , Dredge Keith , Hammond Edward , Block Matthew S. , Kaufmann Scott H. , Bakkum-Gamez Jamie N. , Shridhar Viji
Published: August 2023

PG545 (Pixatimod) is a highly sulfated small molecule known for its ability to inhibit heparanase and disrupt signaling mediated by heparan-binding-growth factors (HB-GF). Previous studies indicated that PG545 inhibits growth factor-mediated signaling in ovarian cancer (OC) to enhance response to chemotherapy. Here we investigated the previously unidentified mechanisms by which PG545 induces DNA damage in OC cells and found that PG545 induces DNA single- and double-strand breaks, reduces RAD51 expression in an autophagy-dependent manner and inhibits homologous recombination repair (HRR). These changes accompanied the ability of PG545 to inhibit endocytosis of the heparan-sulfate proteoglycan interacting DNA repair protein, DEK, leading to DEK sequestration in the tumor microenvironment (TME) and loss of nuclear DEK needed for HRR. As a result, PG545 synergized with poly (ADP-ribose) polymerase inhibitors (PARPis) in OC cell lines in vitro and in 55% of primary cultures of patient-derived ascites samples ex vivo. Moreover, PG545/PARPi synergy was observed in OC cells exhibiting either de novo or acquired resistance to PARPi monotherapy. PG545 in combination with rucaparib also generated increased DNA damage, increased antitumor effects and increased survival of mice bearing HRR proficient OVCAR5 xenografts compared to monotherapy treatment in vivo. Synergistic antitumor activity of the PG545/rucaparib combination was likewise observed in an immunocompetent syngeneic ID8F3 OC model. Collectively, these results suggest that targeting DEK-HSPG interactions in the TME through the use of PG545 may be a novel method of inhibiting DNA repair and sensitizing cells to PARPis.
Baseline azithromycin resistance in the gut microbiota of preterm born infants
Authors: Gallacher David J. , Zhang Lei , Aboklaish Ali F. , Mitchell Emma , Wach Richard , Marchesi Julian R. , Kotecha Sailesh
Published: August 2023

Background

Macrolides, including azithromycin, are increasingly used in preterm-born infants to treatUreaplasmainfections. The baseline carriage of macrolide resistance genes in the preterm stool microbiota is unknown.

Objectives

Identify carriage of azithromycin resistant bacteria and the incidence of macrolide resistant genes.

Methods

Azithromycin resistant bacteria were isolated from serial stool samples obtained from preterm infants (≤32 weeks’ gestation) by culturing aerobically/anaerobically, in the presence/absence of azithromycin. Using quantitative PCR, we targeted 6 common macrolide resistance genes (erm(A),erm(B),erm(C),erm(F),mef(A/E), msr(A)) in DNA extracted from selected bacteria resistant to azithromycin.

Results

From 89 stool samples from 37 preterm-born infants, 93.3% showed bacterial growth in aerobic or anaerobic conditions. From the 280 azithromycin resistant isolates that were identified,Staphylococcus(75%) andEnterococcus(15%) species dominated. Macrolide resistance genes were identified in 91% of resistant isolates: commonest wereerm(C)(46% of isolates) andmsr(A)(40%). Multiple macrolide resistance genes were identified in 18% of isolates.

Conclusion

Macrolide resistance is common in the gut microbiota of preterm-born infants early in life, most likely acquired from exposure to the maternal microbiota. It will be important to assess modulation of macrolide resistance, if macrolide treatment becomes routine in the management of preterm infants.

Impact Statement

Azithromycin resistance is present in the stool microbiota in the first month of life in preterm infants

91% of azithromycin resistant bacteria carried at least one of 6 common macrolide resistant genes

Increasing use of macrolides in the preterm population makes this an important area of study
Differences in rectal amino acid levels determine bacteria-originated sex pheromone specificity in two closely related flies
Authors: Gao Zijie , Xie Mingxue , Gui Shiyu , He Muyang , Lu Yongyue , Wang Luoluo , Chen Jingyuan , Smagghe Guy , Gershenzon Jonathan , Cheng Daifeng
Published: August 2023

Sex pheromones are widely used by insects as a reproductive isolating mechanism to attract conspecifics and repel heterospecifics. Although researchers have obtained extensive knowledge about sex pheromones, little is known about the differentiation mechanism of sex pheromones in closely related species. Using Bactrocera dorsalis and Bactrocera cucurbitae as the study model, we investigated how the male-borne sex pheromones are different. The results demonstrated that both 2,3,5-trimethylpyrazine (TMP) and 2,3,5,6-tetramethylpyrazine (TTMP) were sex pheromones produced by rectal Bacillus in the two flies. However, the TMP/TTMP ratios were reversed, indicating sex pheromone specificity in the two flies. Bacterial fermentation results showed that different threonine and glycine levels were responsible for the preference of rectal Bacillus to produce TMP or TTMP. Accordingly, threonine (glycine) levels and the expression of the threonine and glycine coding genes were significantly different between B. dorsalis and B. cucurbitae. In vivo assays confirmed that increased rectal glycine and threonine levels by amino acid feeding could significantly decrease the TMP/TTMP ratios and result in significantly decreased mating abilities in the studied flies. Meanwhile, decreased rectal glycine and threonine levels due to RNAi of the glycine and threonine coding genes was found to significantly increase the TMP/TTMP ratios and result in significantly decreased mating abilities. The study contributes to the new insight that insects and their symbionts can jointly regulate sex pheromone specificity in insects, and in turn, this helps us to better understand how the evolution of chemical communication affects speciation.