bluuebunny/crossref_metadata_2025 huggingface dataset:
A Scoping Review of Transgender Policies in the 15 Most Commonly Played UK Professional Sports
Authors: McLarnon Michael , Thornton Jane , Knudson Gail , Jones Nigel , Glover Danny , Murray Andrew , Cummings Michael , Heron Neil
Published: February 2023

Introduction: There has been much debate recently on the participation of transgender and gender-diverse (TGD) athletes in sport, particularly in relation to fairness, safety and inclusion. The 2021 IOC Framework on Fairness, Inclusion and Non-discrimination acknowledges the central role that eligibility criteria play in ensuring fairness, particularly in the female category, and states that athletes should not be excluded solely on the basis of their TGD identity. Aims: To identify policies that address TGD athlete participation in the 15 major United Kingdom (UK) sporting organisations and to summarise the evidence for each of these policies. Methods: A scoping review of TGD policies from the 15 major UK sporting organisations. Results: Eleven of the governing bodies had publicly available TGD policies. Most of the sporting associations drew guidance from the official 2015 IOC Consensus Meeting on Sex Reassignment and Hyperandrogenism, particularly with regard to physiological testosterone levels. Many organisations referenced their policies as a guide for decision making but stated that they ultimately made case-by-case decisions on an athlete’s eligibility. Relevant considerations not addressed in most policies included pre- versus post-pubertal athletes, justification for testosterone thresholds, the length of time out of competitive action (if any) for transitioning athletes, the irreversible advantage from male puberty (if any), the responsibility for and frequency of follow up for hormonal testing and the consequences for athletes outside set testosterone limits. Conclusions: There is a lack of consensus among the top 15 UK sporting organizations relating to elite sport participation for TGD athletes. It would be useful for sport organizations to work together to develop greater standardization/consensus for TGD athlete policies, taking into consideration fairness, safety and inclusion in each sport.
Corporate Governance Effects on Bank Profits in Gulf Cooperation Council Countries during the Pandemic
Authors: El-Chaarani Hani , Abraham Rebecca , Khalife Danielle , Salameh-Ayanian Madonna
Published: February 2023

During the COVID-19 lockdown, the typical bank in the Middle East lost liquidity due to deposit drains and experienced increases in nonperforming loans. The loss of liquidity was a supply shock, while the increase in nonperforming loans was a demand shock. Corporate governance increases the board’s oversight of top management’s implementation of strategies to reduce these shocks. Two corporate governance measures include a political concentration in the ownership and the presence of independent directors on the board of directors. Politically connected shareholders can ensure the continuous flow of deposits through their access to large depositors, thereby reducing supply shocks. Supply shocks may also be overcome by the large deposit balances from oil wealth. Independent directors are not employees of the banks on whose boards they serve, thereby providing objective evaluations of management’s performance. Managers who are evaluated by independent directors can reduce nonperforming loans by strictly evaluating the creditworthiness of borrowers and providing incentives for timely repayment. Thus, demand shocks may be overcome by the scrutiny of management by independent directors. These conditions prevail in the Gulf Cooperation Council (GCC countries). Using a sample of 326 GCC banks, we perform OLS regressions followed by two-stage least squares and GMM estimator robustness checks of ownership’s political concentration, independent directors, bank size, and bank liquidity on returns on assets and equity. Ownership political concentration, independent directors, bank size, and liquidity ratio significantly explained the return on assets and on equity. We conclude that large shareholders use political connections to cope with crises and that large banks are able to make new loans due to liquidity from large reserves. Independent directors evaluate management performance objectively, thereby requiring that management reduce nonperforming loans. We close research gaps of bank performance in GCC countries, as opposed to the entire MENA region, the latter being the focus of the literature. The significance of this paper is that it demonstrates the ability of banks to employ corporate governance to cope with crises. This is an original approach, as it seeks the outcome of a positive signal on bank performance of the reduction in the supply shock through ownership political concentration and reduction in the demand shock by independent directors. As corporate governance variables mitigate both shocks, corporate governance may assist banks in coping with liquidity crises.
CSK-CNN: Network Intrusion Detection Model Based on Two-Layer Convolution Neural Network for Handling Imbalanced Dataset
Authors: Song Jiaming , Wang Xiaojuan , He Mingshu , Jin Lei
Published: February 2023

In computer networks, Network Intrusion Detection System (NIDS) plays a very important role in identifying intrusion behaviors. NIDS can identify abnormal behaviors by analyzing network traffic. However, the performance of classifier is not very good in identifying abnormal traffic for minority classes. In order to improve the detection rate on class imbalanced dataset, we propose a network intrusion detection model based on two-layer CNN and Cluster-SMOTE + K-means algorithm (CSK-CNN) to process imbalanced dataset. CSK combines the cluster based Synthetic Minority Over Sampling Technique (Cluster-SMOTE) and K-means based under sampling algorithm. Through the two-layer network, abnormal traffic can not only be identified, but also be classified into specific attack types. This paper has been verified on UNSW-NB15 dataset and CICIDS2017 dataset, and the performance of the proposed model has been evaluated using such indicators as accuracy, recall, precision, F1-score, ROC curve, AUC value, training time and testing time. The experiment shows that the proposed CSK-CNN in this paper is obviously superior to other comparison algorithms in terms of network intrusion detection performance, and is suitable for deployment in the real network environment.
Thermal Oviposition Performance of the Ladybird Stethorus gilvifrons Preying on Two-Spotted Spider Mites
Authors: Jafari Maryam , Aghdam Hossein Ranjbar , Zamani Abbas Ali , Goldasteh Shila , Soleyman-Nejadian Ebrahim , Schausberger Peter
Published: February 2023

The ladybird, Stethorus gilvifrons (Mulsant) (Coleoptera: Coccinellidae), is an important predator of two-spotted spider mites, Tetranychus urticae Koch (Acari: Tetranychidae), in southeastern Europe and western and southwestern Asia, such as Iran, India, and Turkey. To enhance forecasting the occurrence and performance of this predator in natural control and improve its usage in biological control, we evaluated and compared four non-linear oviposition models, i.e., Enkegaard, Analytis, Bieri-1, and Bieri-2. The models were validated by using data of age-specific fecundity of female S. gilvifrons at six constant temperatures (15, 20, 25, 27, 30, and 34 °C). All four models provided good fit quality to age-dependent oviposition at 15 to 30 °C (R2 0.67 to 0.94; R2adj 0.63 to 0.94) but had a poor fit at 34 °C (R2 0.33 to 0.40; R2adj 0.17 to 0.34). Within temperatures, the best performing models were Bieri-1 (R2), Bieri-2 (R2adj), and Analytis (RSS) at 15 °C, Bieri-1 at 27 °C, and Analytis at 20, 25, and 30 °C. Analytis was the best suited model across the wide temperature range tested (from 15 to 30 °C). The models presented here allow for prediction of the population dynamics of S. gilvifrons in field and greenhouse crops in temperate and subtropical climates.
Outcome Prediction of Spontaneous Supratentorial Intracerebral Hemorrhage after Surgical Treatment Based on Non-Contrast Computed Tomography: A Multicenter Study
Authors: Zhang Kangwei , Zhou Xiang , Xi Qian , Wang Xinyun , Yang Baoqing , Meng Jinxi , Liu Ming , Dong Ningxin , Wu Xiaofen , Song Tao , Wei Lai , Wang Peijun
Published: February 2023

This study aims to explore the value of a machine learning (ML) model based on radiomics features and clinical features in predicting the outcome of spontaneous supratentorial intracerebral hemorrhage (sICH) 90 days after surgery. A total of 348 patients with sICH underwent craniotomy evacuation of hematoma from three medical centers. One hundred and eight radiomics features were extracted from sICH lesions on baseline CT. Radiomics features were screened using 12 feature selection algorithms. Clinical features included age, gender, admission Glasgow Coma Scale (GCS), intraventricular hemorrhage (IVH), midline shift (MLS), and deep ICH. Nine ML models were constructed based on clinical feature, and clinical features + radiomics features, respectively. Grid search was performed on different combinations of feature selection and ML model for parameter tuning. The averaged receiver operating characteristics (ROC) area under curve (AUC) was calculated and the model with the largest AUC was selected. It was then tested using multicenter data. The combination of lasso regression feature selection and logistic regression model based on clinical features + radiomics features had the best performance (AUC: 0.87). The best model predicted an AUC of 0.85 (95%CI, 0.75–0.94) on the internal test set and 0.81 (95%CI, 0.64–0.99) and 0.83 (95%CI, 0.68–0.97) on the two external test sets, respectively. Twenty-two radiomics features were selected by lasso regression. The second-order feature gray level non-uniformity normalized was the most important radiomics feature. Age is the feature with the greatest contribution to prediction. The combination of clinical features and radiomics features using logistic regression models can improve the outcome prediction of patients with sICH 90 days after surgery.
Complete, Fully Automatic Detection and Classification of Benign and Malignant Breast Tumors Based on CT Images Using Artificial Intelligent and Image Processing
Authors: Kuo Chung-Feng Jeffrey , Chen Hsuan-Yu , Barman Jagadish , Ko Kai-Hsiung , Hsu Hsian-He
Published: February 2023

Breast cancer is the most common type of cancer in women, and early detection is important to significantly reduce its mortality rate. This study introduces a detection and diagnosis system that automatically detects and classifies breast tumors in CT scan images. First, the contours of the chest wall are extracted from computed chest tomography images, and two-dimensional image characteristics and three-dimensional image features, together with the application of active contours without edge and geodesic active contours methods, are used to detect, locate, and circle the tumor. Then, the computer-assisted diagnostic system extracts features, quantifying and classifying benign and malignant breast tumors using a greedy algorithm and a support vector machine. The study used 174 breast tumors for experiment and training and performed cross-validation 10 times (k-fold cross-validation) to evaluate performance of the system. The accuracy, sensitivity, specificity, and positive and negative predictive values of the system were 99.43%, 98.82%, 100%, 100%, and 98.89% respectively. This system supports the rapid extraction and classification of breast tumors as either benign or malignant, helping physicians to improve clinical diagnosis.
Red Blood Cell Distribution Width: A Risk Factor for Prognosis in Patients with Ischemic Cardiomyopathy after Percutaneous Coronary Intervention
Authors: Zhang Biyang , Xu Yinxiao , Huang Xin , Sun Tienan , Ma Meishi , Chen Zheng , Zhou Yujie
Published: February 2023

Background: It has been demonstrated in previous studies that red blood cell distribution width (RDW) is correlated with the severity and prognosis of cardiovascular disease. The target of our study was to assess the relationship between RDW and the prognosis of ischemic cardiomyopathy (ICM) patients undergoing percutaneous coronary intervention (PCI). Methods: The study retrospectively enrolled 1986 ICM patients undergoing PCI. The patients were divided into three groups by RDW tertiles. The primary endpoint was major adverse cardiovascular events (MACE) and the secondary endpoints were each of the components of MACE (all-cause mortality, nonfatal myocardial infarction (MI) and any revascularization). Kaplan–Meier survival analyses were conducted to show the association between RDW and the incidence of adverse outcomes. The independent effect of RDW on adverse outcomes was determined by multivariate Cox proportional hazard regression analysis. In addition, the nonlinear relationship between RDW values and MACE was explored using restricted cubic spline (RCS) analysis. The relationship between RDW and MACE in different subgroups was determined using subgroup analysis. Results: As RDW tertiles increased, the incidences of MACE (Tertile 3 vs. Tertile 1: 42.6 vs. 23.7, p < 0.001), all-cause death (Tertile 3 vs. Tertile 1: 19.3 vs. 11.4, p < 0.001) and any revascularization (Tertile 3 vs. Tertile 1: 20.1 vs. 14.1, p < 0.001) increased significantly. The K–M curves showed that higher RDW tertiles were related to increased incidences of MACE (log-rank, p < 0.001), all-cause death (log-rank, p < 0.001) and any revascularization (log-rank, p < 0.001). After adjusting for confounding variables, RDW was proved to be independently associated with increased risks of MACE (Tertile 3 vs. Tertile 1: HR, 95% CI: 1.75, 1.43–2.15; p for trend < 0.001), all-cause mortality (Tertile 3 vs. Tertile 1: HR, 95% CI: 1.58, 1.17–2.13; p for trend < 0.001) and any revascularization (Tertile 3 vs. Tertile 1: HR, 95% CI: 2.10, 1.54–2.88; p for trend < 0.001). In addition, the RCS analysis suggested nonlinear association between RDW values and MACE. The subgroup analysis revealed that elderly patients or patients with angiotensin receptor blockers (ARBs) had a higher risk of MACE with higher RDW. Patients with hypercholesterolemia or without anemia also had a higher risk of MACE. Conclusions: RDW was significantly related to the increased risk of MACE among ICM patients undergoing PCI.
Effects of Tele-Pilates and Tele-Yoga on Biochemicals, Physical, and Psychological Parameters of Females with Multiple Sclerosis
Authors: Najafi Parisa , Hadizadeh Maryam , Cheong Jadeera Phaik Geok , Mohafez Hamidreza , Abdullah Suhailah , Poursadeghfard Maryam
Published: February 2023

Background: People with multiple sclerosis (PwMS) suffer from some comorbidities, including physical and psychiatric disorders, low quality of life (QoL), hormonal dysregulation, and hypothalamic-pituitary-adrenal axis dysfunction. The current study aimed to investigate the effects of eight weeks of tele-yoga and tele-Pilates on the serum levels of prolactin and cortisol and selected physical and psychological factors. Methods: Forty-five females with relapsing remitting multiple sclerosis, based on age (18–65), expanded disability status scale (0–5.5), and body mass index (20–32), were randomly assigned to tele-Pilates, tele-yoga, or control groups (n = 15). Serum blood samples and validated questionnaires were collected before and after interventions. Results: Following online interventions, there was a significant increase in the serum levels of prolactin (p = 0.004) and a significant decrease in cortisol (p = 0.04) in the time × group interaction factors. In addition, significant improvements were observed in depression (p = 0.001), physical activity levels (p < 0.001), QoL (p ≤ 0.001), and the speed of walking (p < 0.001). Conclusion: Our findings suggest that tele-yoga and tele-Pilates training could be introduced as patient-friendly, non-pharmacological, add-on therapeutic methods for increasing prolactin and decreasing cortisol serum levels and achieving clinically relevant improvements in depression, walking speed, physical activity level, and QoL in female MS patients.
Improvement of Left Ventricular Global Longitudinal Strain after 6-Month Therapy with GLP-1RAs Semaglutide and Dulaglutide in Type 2 Diabetes Mellitus: A Pilot Study
Authors: Basile Paolo , Guaricci Andrea Igoren , Piazzolla Giuseppina , Volpe Sara , Vozza Alfredo , Benedetto Marina , Carella Maria Cristina , Santoro Daniela , Monitillo Francesco , Baggiano Andrea , Mushtaq Saima , Fusini Laura , Fazzari Fabio , Forleo Cinzia , Ribecco Nunziata , Pontone Gianluca , Sabbà Carlo , Ciccone Marco Matteo
Published: February 2023

(1) Background: Glucagone-Like Peptide-1 Receptor Agonists (GLP-1 RAs) (GLP-1 RAs) are incretine-based medications recommended in the treatment of type 2 Diabetes Mellitus (DM2) with atherosclerotic cardiovascular disease (ASCVD) or high or very high cardiovascular (CV) risk. However, knowledge of the direct mechanism of GLP-1 RAs on cardiac function is modest and not yet fully elucidated. Left ventricular (LV) Global Longitudinal Strain (GLS) with Speckle Tracking Echocardiography (STE) represents an innovative technique for the evaluation of myocardial contractility. (2) Methods: an observational, perspective, monocentric study was conducted in a cohort of 22 consecutive patients with DM2 and ASCVD or high/very high CV risk, enrolled between December 2019 and March 2020 and treated with GLP-1 RAs dulaglutide or semaglutide. The echocardiographic parameters of diastolic and systolic function were recorded at baseline and after six months of treatment. (3) Results: the mean age of the sample was 65 ± 10 years with a prevalence of the male sex (64%). A significant improvement in the LV GLS (mean difference: −1.4 ± 1.1%; p value < 0.001) was observed after six months of treatment with GLP-1 RAs dulaglutide or semaglutide. No relevant changes were seen in the other echocardiographic parameters. (4) Conclusions: six months of treatment with GLP-1 RAs dulaglutide or semaglutide leads to an improvement in the LV GLS in subjects with DM2 with and high/very high risk for ASCVD or with ASCVD. Further studies on larger populations and with a longer follow-up are warranted to confirm these preliminary results.
Efficacy of PARP Inhibitor, Platinum, and Immunotherapy in BRCA-Mutated HER2-Negative Breast Cancer Patients: A Systematic Review and Network Meta-Analysis
Authors: Sun Wanyi , Wu Yun , Ma Fei , Fan Jinhu , Qiao Youlin
Published: February 2023

The optimal treatment regimen for breast cancer patients with gBRCA mutations remains controversial given the availability of numerous options, such as platinum-based agents, polymerase inhibitors (PARPis), and other agents. We included phase II or III RCTs and estimated the HR with 95% CI for OS, PFS, and DFS, in addition to the OR with 95% CI for ORR and pCR. We determined the treatment arm rankings by P-scores. Furthermore, we carried out a subgroup analysis in TNBC and HR-positive patients. We conducted this network meta-analysis using R 4.2.0 and a random-effects model. A total of 22 RCTs were eligible, involving 4253 patients. In the pairwise comparisons, PARPi + Platinum + Chemo was better than PARPi + Chemo for OS (in whole study group and in both subgroups) as well as PFS. The ranking tests demonstrated that PARPi + Platinum + Chemo ranked first in PFS, DFS, and ORR. Platinum + Chemo showed higher OS than PARPi + Chemo. The ranking tests for PFS, DFS, and pCR indicated that, except for the best treatment (PARPi + Platinum + Chemo) containing PARPi, the second and third treatments were platinum monotherapy or platinum-based chemotherapy. In conclusion, PARPi + Platinum + Chemo might be the best regime for gBRCA-mutated BC. Platinum drugs showed more favorable efficacy than PARPi in both combination and monotherapy.
Correlation of UGT1A1 Gene Polymorphisms or Prior Irinotecan Treatment and Treatment Outcomes of Nanoliposomal-Irinotecan plus 5-Fluorouracil/Leucovorin for Pancreatic Ductal Adenocarcinoma: A Multicenter, Retrospective Cohort Study (HGCSG2101)
Authors: Harada Kazuaki , Yamamura Takahiro , Muto Osamu , Nakamura Michio , Sogabe Susumu , Sawada Kentaro , Nakano Shintaro , Yagisawa Masataka , Muranaka Tetsuhito , Dazai Masayoshi , Tateyama Miki , Kobayashi Yoshimitsu , Kato Sosuke , Hatanaka Kazuteru , Kawamoto Yasuyuki , Yuki Satoshi , Sakata Yuh , Sakamoto Naoya , Komatsu Yoshito
Published: February 2023

The effects of UGT1A1 gene polymorphisms or prior irinotecan treatment on treatment outcomes of nanoliposomal-irinotecan plus 5-fluorouracil/leucovorin (nal-IRI+5-FU/LV) in patients with unresectable pancreatic ductal adenocarcinoma (PDAC) are not established. This multicenter, retrospective cohort study compared treatment outcomes in patients with UGT1A1*1/*1 and those with UGT1A1*1/*6 or *1/*28 genotypes. We also analyzed the impact of prior irinotecan treatment on survival outcomes in 54 patients treated with nal-IRI+5-FU/LV. Comparable effectiveness was found regardless of the UGT1A1 genotypes. While no significant differences were found, grade ≥3 neutropenia and febrile neutropenia were more frequent in patients with UGT1A1*1/*6 or *1/*28 than in those with UGT1A1*1/*1 genotypes (grade ≥3 neutropenia, 50.0% vs. 30.8%, p = 0.24; febrile neutropenia, 9.1% vs. 0.0%, p = 0.20, respectively). No significant difference in progression-free survival (PFS) and overall survival (OS) was observed between irinotecan-naïve-patients and other patients. However, irinotecan-resistant patients showed significantly shorter PFS (hazard ratio (HR) 2.83, p = 0.017) and OS (HR 2.58, p = 0.033) than other patients. Our study indicated that patients with UGT1A1*1/*6 or *1/*28 may be prone to neutropenia, though further study is needed. The survival benefit of nal-IRI+5-FU/LV could be maintained in patients without disease progression after irinotecan therapy.
Associated Impairments among Children with Cerebral Palsy in Rural Bangladesh—Findings from the Bangladesh Cerebral Palsy Register
Authors: Narayan Aditya , Muhit Mohammad , Whitehall John , Hossain Iskander , Badawi Nadia , Khandaker Gulam , Jahan Israt
Published: February 2023

Background: We aimed to describe the burden, severity, and underlying factors of associated impairments among children with cerebral palsy (CP) in rural Bangladesh. Methods: This study reports findings from the Bangladesh Cerebral Palsy Register—the first population-based surveillance of children with CP in any LMIC, where children with confirmed CP aged < 18 years are registered by a multidisciplinary team following a standard protocol. Associated impairments were documented based on clinical assessment, available medical records, and a detailed clinical history provided by the primary caregivers. Descriptive analysis, as well as unadjusted and adjusted logistic regression, were completed using R. Results: Between January 2015 and February 2022, 3820 children with CP were registered (mean (SD) age at assessment: 7.6 (5.0) y; 39% female). Overall, 81% of children had ≥1 associated impairment; hearing: 18%, speech: 74%, intellectual: 40%, visual: 14%, epilepsy: 33%. The presence of a history of CP acquired post-neonatally and having a gross motor function classification system levels III–V significantly increased the odds of different types of associated impairments in these children. Most of the children had never received any rehabilitation services and were not enrolled in any mainstream or special education system. Conclusions: The burden of associated impairments was high among children with CP, with comparatively low receipt of rehabilitation and educational services in rural Bangladesh. Comprehensive intervention could improve their functional outcome, participation, and quality of life.
Development of an RNase H2 Activity Assay for Clinical Screening
Authors: Schulz Marian Simon , Sartorius von Bach Cay Bennet , Marinkovic Emilija , Günther Claudia , Behrendt Rayk , Roers Axel
Published: February 2023

As the key enzyme mediating ribonucleotide excision repair, RNase H2 is essential for the removal of single ribonucleotides from DNA in order to prevent genome damage. Loss of RNase H2 activity directly contributes to the pathogenesis of autoinflammatory and autoimmune diseases and might further play a role in ageing and neurodegeneration. Moreover, RNase H2 activity is a potential diagnostic and prognostic marker in several types of cancer. Until today, no method for quantification of RNase H2 activity has been validated for the clinical setting. Herein, validation and benchmarks of a FRET-based whole-cell lysate RNase H2 activity assay are presented, including standard conditions and procedures to calculate standardized RNase H2 activity. Spanning a wide working range, the assay is applicable to various human cell or tissue samples with overall methodological assay variability from 8.6% to 16%. Using our assay, we found RNase H2 activity was reduced in lymphocytes of two patients with systemic lupus erythematosus and one with systemic sclerosis carrying heterozygous mutations in one of the RNASEH2 genes. Implementation of larger control groups will help to assess the diagnostic and prognostic value of clinical screening for RNase H2 activity in the future.
Peri-Operative Risk Factors Associated with Post-Operative Cognitive Dysfunction (POCD): An Umbrella Review of Meta-Analyses of Observational Studies
Authors: Travica Nikolaj , Lotfaliany Mojtaba , Marriott Andrew , Safavynia Seyed A. , Lane Melissa M. , Gray Laura , Veronese Nicola , Berk Michael , Skvarc David , Aslam Hajara , Gamage Elizabeth , Formica Melissa , Bishop Katie , Marx Wolfgang
Published: February 2023

This umbrella review aimed to systematically identify the peri-operative risk factors associated with post-operative cognitive dysfunction (POCD) using meta-analyses of observational studies. To date, no review has synthesised nor assessed the strength of the available evidence examining risk factors for POCD. Database searches from journal inception to December 2022 consisted of systematic reviews with meta-analyses that included observational studies examining pre-, intra- and post-operative risk factors for POCD. A total of 330 papers were initially screened. Eleven meta-analyses were included in this umbrella review, which consisted of 73 risk factors in a total population of 67,622 participants. Most pertained to pre-operative risk factors (74%) that were predominantly examined using prospective designs and in cardiac-related surgeries (71%). Overall, 31 of the 73 factors (42%) were associated with a higher risk of POCD. However, there was no convincing (class I) or highly suggestive (class II) evidence for associations between risk factors and POCD, and suggestive evidence (class III) was limited to two risk factors (pre-operative age and pre-operative diabetes). Given that the overall strength of the evidence is limited, further large-scale studies that examine risk factors across various surgery types are recommended.
One-Leg Stance Postural Sway Is Not Benefited by Bicycle Motocross Practice in Elite Riders
Authors: Albaladejo-García Carlos , Moreno Francisco J. , García-Aguilar Fernando , Caballero Carla
Published: February 2023

Balance has been positioned as an important performance skill in sport. Differences in postural control have been found between levels of expertise. However, this statement remains unanswered in some cyclic sports. This work aimed to describe the one-leg balance performance of a sample of elite BMX riders—racing and freestyle—compared to a control group formed by recreational athletes. The center of pressure (COP) of nineteen international BMX riders (freestyle, n = 7; racing, n = 12) and twenty physically active adults was analyzed in a 30-s one-leg stance test on both legs. COP dispersion and velocity variables were analyzed. Non-linear dynamics of postural sway were evaluated through Fuzzy Entropy and Detrended Fluctuation Analysis. BMX athletes did not show differences between legs in any of the variables. The control group did show differences between the dominant and non-dominant leg in the magnitude of variability of the COP in the mediolateral axis. Group comparison revealed non-significant differences. International BMX athletes did not show better balance parameters than the control group in a one-leg stance balance task. The adaptations derived from BMX practice do not have a significant impact in one-leg stance balance performance.
Citizen Science and Expert Judgement: A Cost-Efficient Combination to Monitor and Assess the Invasiveness of Non-Indigenous Fish Escapees
Authors: Parretti Paola , Monteiro João Gama , Gizzi Francesca , Martínez-Escauriaza Roi , Alves Filipe , Chebaane Sahar , Almeida Silvia , Pessanha Pais Miguel , Almada Frederico , Fernandez Marc , Nogueira Natacha , Andrade Carlos , Canning-Clode João
Published: February 2023

Mapping the distribution and evaluating the impacts of marine non-indigenous species (NIS) are two fundamental tasks for management purposes, yet they are often time consuming and expensive. This case study focuses on the NIS gilthead seabream Sparus aurata escaped from offshore farms in Madeira Island in order to test an innovative, cost-efficient combined approach to risk assessment and georeferenced dispersal data collection. Species invasiveness was screened using the Aquatic Species Invasiveness Screening Kit (AS-ISK), and revealed a high invasion risk. Occurrences of S. aurata were assessed involving citizens in GIS participatory mapping and data from recreational fishing contests. A probability map showed that S. aurata is well dispersed around Madeira Island. This assessment proved to be a cost-efficient early warning method for detecting NIS dispersal, highlighting the urgent need for additional surveys that should search for sexually mature individuals and assess the direct and indirect impacts in the native ecosystem.
A Curved Plate-Flattening Method to Construct the Membrane Strain Distribution
Authors: Chang Lichun , Zhao Yao , Yuan Hua , Wei Zhenshuai
Published: February 2023

The surface-flattening process has many applications in industries such as shipbuilding. Curved surfaces in the industry are usually formed from flat surfaces, so the target surface needs to be flattened to obtain its corresponding initial shape. In addition, the surface flattening process obtains the inherent strain distribution required in forming. Different forming methods in the plate forming process will produce different membrane deformations, such as shrinkage in the line heating and tensile in the roller forming. Therefore, different surface-flattening methods should be used to obtain the inherent strain distribution suitable for different forming methods. This paper proposes a method to perform the surface flattening using the finite element method and constrain the membrane strain generated in the flattening deformation by modifying the material constitutive relationship. Using a dual modulus material constitutive model in membrane deformation makes the surface more inclined to deform at locations with less stiffness during the flattening process. This method yields predominantly tensile or compressive membrane strain without changing the bending strain. By modifying the material model, this method can control the compressive strain region and the principal strain direction. The results of the proposed method applying to different surface shapes and its application in the surface-forming process are given in this paper.
Trace Element Evidence of Subduction-Modified Mantle Material in South Mid-Atlantic Ridge 18–21°S Upper Mantle
Authors: Ji Tianxiao , Zeng Zhigang
Published: February 2023

Mid-ocean ridge basalts (MORBs), produced at mid-ocean ridge where the continents and subduction zones are distant, are the product of partial melting of the upper mantle and their chemical composition can provide information about the mantle itself. The geochemical characteristics of MORBs enable us to be more informed about the geological processes of the upper mantle below the mid-ocean ridge, and assist us in understanding mantle heterogeneity and geodynamic processes. In this paper, new data of major elements, trace elements, and Nd-Hf isotopes of south mid-Atlantic ridge (SMAR) 18–21°S MORBs are presented. TAS diagram shows that the samples belong to subalkaline basalt compositional field. Trace elements (e.g., (La/Sm)N = 0.49–0.79) show that the samples are N-MORBs. However, the primitive mantle-normalized trace element patterns showed that the studied samples were clearly enriched in Rb, U, Pb, and other fluid-mobile elements. Meanwhile, the trace element ratios, such as Nb/U and Ce/Pb, are also significantly different from the typical N-MORB. Combined with the Nd-Hf isotopic composition, we propose that these anomalies are not related to continental crust material, delaminated subcontinental lithospheric mantle (SCLM), recycled sediments, direct supply of mantle plume, nor are they the result of subduction directly affecting the mantle source, but are caused by the incorporation of mantle material modified by subduction.
The Effect of Environmental Dredging of Muck on an Assemblage of Benthic Amphipods
Authors: Mallick Nayan , Johnson Kevin B. , Jacoby Charles A.
Published: February 2023

To yield environmental benefits, fine sediments with ~10% organic matter, termed muck, were dredged from a tributary to the Indian River Lagoon. Key changes were documented by sampling amphipods, sediments, and the water column near the bottom before dredging, and approximately one month and one year after dredging. Overall, muck yielded the fewest taxa, muck or sediments in creeks that were dredged yielded a moderate number of taxa, and undisturbed sediments in the lagoon yielded the highest number of taxa. Amphipods did not appear in areas with muck until one month and one year after dredging. In contrast, amphipods in sediments that were not muck decreased after dredging. Increases in the occurrence of amphipods paralleled increases in concentrations of dissolved oxygen and decreases in the water, silt/clay, and organic content of sediments. Overall, results indicated that conditions for amphipods were improved by removing muck, and that dredging sandier sediment led to decreased taxonomic richness and numbers of amphipods, which resembled the effects of navigational dredging. Thus, this study suggested that managers should consider the type of sediment to be dredged when permitting projects.
Whole Genome Sequence of an Edible Mushroom Oudemansiella raphanipes (Changgengu)
Authors: Zhu Liping , Gao Xia , Zhang Meihua , Hu Chunhui , Yang Wujie , Guo Lizhong , Yang Song , Yu Hailong , Yu Hao
Published: February 2023

Oudemansiella raphanipes, considered as a well-known culinary edible mushroom with a high content of natural bioactive substances, is widely cultivated in China with the commercial name Changgengu. However, due to the lack of genomic data, molecular and genetic study on O. raphanipes is rare. To obtain a comprehensive overview of genetic characteristics and enhance the value of O. raphanipes, two mating-compatible monokaryons isolated from the dikaryon were applied for de novo genome sequencing and assembly using Nanopore and /or Illumina sequencing platforms. One of the monokaryons, O. raphanipes CGG-A-s1, was annotated with 21,308 protein-coding genes, of which 56 were predicted to be involved in the biosynthesis of secondary metabolites such as terpene, type I PKS, NRPS, and siderophore. Phylogenetic and comparative analysis of multiple fungi genomes revealed a close evolutionary relationship between O. raphanipes and Mucidula mucid based on single-copy orthologous protein genes. Significant collinearity was detected between O. raphanipes and Flammulina velutipes on the synteny of inter-species genomes. 664 CAZyme genes in CGG-A-s1 were identified with GHs and AAs families significantly elevated when compared with the other 25 sequenced fungi, indicating a strong wood degradation ability. Furthermore, the mating type locus analysis revealed that CGG-A-s1 and CGG-A-s2 were conserved in the gene organization of the mating A locus but various in that of the mating B locus. The genome resource of O. raphanipes will provide new insights into its development of genetic studies and commercial production of high-quality varieties.
Effect of Surgical Release of Entrapped Peripheral Nerves in Sensorimotor Diabetic Neuropathy on Pain and Sensory Dysfunction—Study Protocol of a Prospective, Controlled Clinical Trial
Authors: Daeschler Simeon C. , Pennekamp Anna , Tsilingiris Dimitrios , Bursacovschi Catalina , Aman Martin , Eisa Amr , Boecker Arne , Klimitz Felix , Stolle Annette , Kopf Stefan , Schwarz Daniel , Bendszus Martin , Kneser Ulrich , Kender Zoltan , Szendroedi Julia , Harhaus Leila
Published: February 2023

Background: Nerve entrapment has been hypothesized to contribute to the multicausal etiology of axonopathy in sensorimotor diabetic neuropathy. Targeted surgical decompression reduces external strain on the affected nerve and, therefore, may alleviate symptoms, including pain and sensory dysfunction. However, its therapeutic value in this cohort remains unclear. Aim: Quantifying the treatment effect of targeted lower extremity nerve decompression in patients with preexisting painful sensorimotor diabetic neuropathy and nerve entrapment on pain intensity, sensory function, motor function, and neural signal conduction. Study design: This prospective, controlled trial studies 40 patients suffering from bilateral therapy-refractory, painful (n = 20, visual analogue scale, VAS ≥ 5) or painless (n = 20, VAS = 0) sensorimotor diabetic neuropathy with clinical and/or radiologic signs of focal lower extremity nerve compression who underwent unilateral surgical nerve decompression of the common peroneal and the tibial nerve. Tissue biopsies will be analyzed to explore perineural tissue remodeling in correlation with intraoperatively measured nerve compression pressure. Effect size on symptoms including pain intensity, light touch threshold, static and moving two-point discrimination, target muscle force, and nerve conduction velocity will be quantified 3, 6, and 12 months postoperatively, and compared (1) to the preoperative values and (2) to the contralateral lower extremity that continues non-operative management. Clinical significance: Targeted surgical release may alleviate mechanical strain on entrapped lower extremity nerves and thereby potentially improve pain and sensory dysfunction in a subset of patients suffering from diabetic neuropathy. This trial aims to shed light on these patients that potentially benefit from screening for lower extremity nerve entrapment, as typical symptoms of entrapment might be erroneously attributed to neuropathy only, thereby preventing adequate treatment.
Outcome Evaluation of Distal Femoral Fractures Following Surgical Management: A Retrospective Cohort Study
Authors: Neumann-Langen Mirjam V. , Sontheimer Verena , Borchert Gudrun H. , Izadpanah Kaywan , Schmal Hagen , Kubosch Eva J.
Published: February 2023

Background: Distal femur fractures are challenging in surgical management as the outcome is crucial for restoring the biomechanical stability and longitudinal axis of the leg and function of the knee joint. Methods: A retrospective review of all distal femoral fractures treated in a level I trauma center over a decade was performed. The radiographs were reviewed for fracture entity, osseous healing, implant failure, mechanical axis, and degenerative joint changes. Clinical outcome was reviewed regarding postoperative complications and postoperative range of motion of the knee joint. Results: 130 patients who were managed with screw fixation (n = 35), plating systems (n = 92) or intramedullary nailing systems (n = 3) remained for evaluation. Mean follow up was 26 months. Clinical outcome was significantly better for flexion degrees following screw fixation (p = 0.009). Delayed fracture union (p = 0.002) or non-union (p = 0.006) rates were significantly higher in plate osteosynthesis. Mild pathologic deformity for varus and valgus collapse was found following plate osteosynthesis. Conclusions: Screw fixation shows fewer postoperative complications than plate fixation and is favored for extra and partial intraarticular distal femur fractures. Plating constructs remain the superior fixation method in complex distal femur fractures but are associated with higher rates of non-union and leg axis deviation.
Sex Differences in the Treatment of Uveal Melanoma in a Group of 1336 Patients
Authors: Romanowska-Dixon Bożena , Dębicka-Kumela Magdalena , Śmigielski Janusz , Nowak Michał Szymon
Published: February 2023

(1) Background: The aim of this study was to analyze the sex differences in the treatment of uveal melanoma (UM) in a group of 1336 patients from a national referral center during the period 2018–2021. (2) Materials and Methods: The study was designed in a retrospective manner. A total of 1336 patients who were newly diagnosed with UM at the Department of Ophthalmology and Ophthalmic Oncology, Jagiellonian University Collegium Medicum, Krakow, Poland, between 1 January 2018 and 31 December 2021, were included in the study. The demographic and clinical data were compiled, including the sex of patients and the treatment methods. (3) Results: In total, 1336 patients with ocular melanoma were identified, including 726 women (54.34%) and 610 men (45.66%). A total of 49.70% of tumors were localized in the right eye and 50.30% in the left eye. UMs were localized statistically significantly more frequently posterior to the equator of the eye globe in men than in women (79.67% vs. 74.10%, Chi^2 Pearson test p = 0.035). Tumors tended to be larger in men, but this difference was not clinically significant. Men were enucleated more often than women (23.44% vs. 18.04%, Chi^2 Pearson test p = 0.015). (4) Conclusions: Statistically significant sex differences were found in the treatment of uveal melanoma in a national referral center in Poland, with men being enucleated more often than women.
The AGP Model for Risk Management in Agile I.T. Projects
Authors: Singh Sanjeet , Madaan Geetika , Singh Amrinder , Sood Kiran , Grima Simon , Rupeika-Apoga Ramona
Published: February 2023

The vast majority of articles on risk in agile-managed projects fail to adequately address the interplay between the agile methodology, the risk management process, and the elements that ultimately determine the success or failure of the project. Too frequently, processes and models are given undue priority over the human element. The aim of this article is to create a risk management model for agile I.T. projects (AGP model). The study sample consists of 1868 valid survey responses from European and Asian countries received between February 2022 and January 2023. We subjected the data to Exploratory Factor Analysis (EFA) and Cronbach’s alpha to identify four key factors for dealing with risks in I.T. projects and create the AGP model. The proposed AGP model outlines up to 76% variability in the potential risks that could arise during an I.T. project’s deployment. The findings of this study are critical for project managers, I.T. professionals, developers, and system architects involved in I.T. projects. Other stakeholders may be interested in understanding the risks associated with the project and developing strategies to mitigate these risks.
Sustainable Collaborative Strategies of Territorial Regeneration for the Cultural Enhancement of Unresolved Landscapes
Authors: Della Spina Lucia , Carbonara Sebastiano , Stefano Davide , Viglianisi Angela
Published: February 2023

The experience of adaptation and instability to a plurality of threats that question the life of human beings on the planet, from the post-pandemic to political conflicts, up to the danger looming in the background—the upheavals expected from climate change—impose a reflection that recognizes that landscape/cultural heritage plays a key role in preservation/enhancement as a specific resource for its “human-centered development”, based on values included. These threats are challenges in which phenomena that require solidarity and common actions are faced, which should lead humans to cooperate to face them. The European Landscape Convention of 2000 attributed an important role to the landscape, as an “essential component of the life context of peoples”. The phase of listening to the territory and participatory and co-design processes are necessary tools for understanding the expectations and perceptions of the communities, co-exploring possible new uses of the landscape, being capable of generating added value for all stakeholders, and adopting a “win-win” approach. From this perspective, this contribution poses the following research question: how to build collaborative processes capable of putting local institutions, businesses, and local communities in synergy, to identify enhancement strategies for the cultural landscape? This study explores the potential of an integrated, incremental, and adaptive decision-making approach, oriented toward the elaboration of shared choices aimed at the elaboration of territorial enhancement strategies attentive to the specificity of the multiple values and complex resources that characterize the cultural terraced landscapes of the Costa Viola (Italy). In particular, the interactions between different knowledge, approaches, and tools makes it possible to formulate scenarios, strategies, and actions, contributing to the creation of a richer and more complex context of knowledge of the territory and to the construction of bottom-up and situated transformation strategies, supported from a decision-making process attentive to the identification of values and an understanding of the needs of the local ‘landscape community’ who live and animate it.
Mineralogy, Geochemistry and Environmental Hazards of Different Types of Mining Waste from a Former Mediterranean Metal Mining Area
Authors: Rodríguez-Pacheco Roberto , García Gregorio , Caparrós-Ríos Ana Vanessa , Robles-Arenas Virginia , García-García Cristóbal , Millán Rocío , Pérez-Sanz Araceli , Alcolea-Rubio Luis Alberto
Published: February 2023

Mine waste constitutes one of the biggest environmental and management problems, both due to its quantity and its danger when they are rich in toxic elements. There is a wide variety of waste from the oxidation of ores in metal mining areas, both metal sulphide and other minerals. These residues may be enriched in potentially toxic elements that can spread and contaminate ecosystems, farmland and villages. This study has focused on the characterization and evaluation of residues derived from metal-bearing mining waste in abandoned mining areas. Mineralogy and geochemical characteristics were determined by XRD, WDXRF and TG-MS techniques. In addition, DIN 38414-S4 leaching tests were carried out to assess the risk and mobility of potentially toxic elements. Silicates and oxides were found as the main mineral groups, followed by sulphates. These tailings were particularly enriched in Zn, Pb, As, Sb and Cd, while their leachates had high or extreme metal content. Consequently, these mining wastes are considered toxic and hazardous, even for landfills. Sulphides, as the primary source, and sulphates from their oxidation, were the main sources of these pollutants. Sulphates, As, Zn, Cd and Cu determined the specific environmental impact of the different tailing types, which were grouped into different clusters according to their mineralogy and geochemistry. These results provided a better understanding of the environmental hazards associated with the different types of metal mining waste in the area studied.