bluuebunny/crossref_metadata_2025 huggingface dataset:
The Determinants of Healthcare Service Quality in Hospitals in Cities/Districts in Central Java
Authors: Adnanti Wenny Ana , Tri Mulyaningsih
Published: September 2023

This study aims to analyze the determinants of healthcare service quality in hospitals in cities/districts in Central Java, with healthcare services as the dependent variable and the number of general practitioners, specialist doctors, healthcare personnel, bed capacity, population size, hospital level in cities/districts, and economic growth as the independent variables.The research method used in this study is a descriptive analytic study with a quantitative approach. Secondary data were utilized, including hospital data from the Indonesian Ministry of Health website, economic data from the Central Bureau of Statistics (BPS) of Central Java website, and population data from the Indonesian Ministry of Home Affairs website. The research sample consists of 86 hospitals.The study employs a logistic regression analysis model where the dependent variable is a binary variable. The analysis results indicate a significant positive relationship between the number of specialist doctors and healthcare service quality. However, the number of general practitioners, healthcare personnel, bed capacity, population size, hospital level, and economic growth have less significant influence on healthcare service quality.These findings underscore the importance of human resources factors, such as the number of specialist doctors, in improving healthcare service quality. Therefore, support should be provided to encourage doctors to specialize in various medical fields. It is hoped that these findings can serve as a basis for making better decisions in human resources planning, thereby ensuring the provision of high-quality healthcare services to the public in cities/districts in Central Java.
Planning and Management of Village Funds for The Development of Cunca Wulang Tourism Village
Authors: Deliman Ludgardis
Published: September 2023

This study aims to identify and understand the system of planning and managing village funds for the development of tourist villages in Cunca Wulang. This type of research is descriptive type using primary and secondary data collected using observation, interview and documentation techniques. Data collection techniques were carried out by direct question-and-answer interviews with research informants, observations and interviews. The results of the research show that the planning and management of village funds is carried out in two stages by the Cunca Wulang village government. The first stage of village fund planning and management begins with the establishment of a village mid-term planning and management team (RPJMDesa). Formation of the RPJMDes planning team, preparation of the RPJMDesa and RKPDes documents so that they become the APBDes up to the preparation of the APBDes. In the second stage, the Cunca Wulang village government for tourism development has a tourism planning stage which is the most basic stage for the development of a tourist village. This planning stage involves the community in preparing plans so that the community can find out how to develop existing nature tourism, besides that they can feel the impact of the existence of a tourism village on the environment around the tour.
Innovating for the Future: A Bibliometric Examination of Business Strategy Research and the Pursuit of Market Leadership
Authors: Mardiah Ainil , Ramadhi  , Santy Sriharyati  , Erwina Kartika Devi
Published: September 2023

This research conducts a comprehensive bibliometric analysis of the literature on business strategy and the pursuit of market leadership. By employing bibliometric techniques and leveraging the VOSviewer software, the study identifies key authors, journals, keywords, and citation patterns within the field. The analysis reveals influential contributors, emerging trends, and interconnected themes that have shaped strategic thinking. The study offers valuable insights for scholars, practitioners, and policymakers seeking to understand the dynamics of business strategy and its implications for achieving market leadership. By examining the evolution of research, the research methodology, results, and discussions, this research aims to contribute to informed decision-making and future research directions in the pursuit of market leadership.
Charting the Path of Financial and Monetary Economics: A Bibliometric Examination of Publication Patterns and Research Productivity
Authors: Ariawan Ariawan , Sudarmanto Eko , Muhammad Syafri  , Samalua Waoma
Published: September 2023

The dynamic landscape of financial and monetary economics has witnessed an evolution marked by scholarly publications that delve into the intricate dynamics of financial systems, monetary policies, and their far-reaching implications. Employing bibliometric analysis, this study maps the trajectory of these fields by scrutinizing publication patterns, research collaborations, influential authors, and emerging research areas. The analysis of comprehensive datasets derived from reputable academic databases provides a comprehensive view of the growth trends, collaborative networks, and research themes within the realm of financial and monetary economics. Utilizing a range of bibliometric indicators and visualization techniques, this research uncovers the historical journey and prevailing patterns that have shaped these vital domains. The findings of this study hold significance for researchers, policymakers, and academic institutions, aiding informed decision-making, innovative research, and effective policy formulation.
Unraveling the Secrets of Strategic Business Planning: A Pathway to Sustainable Growth and Competitive Advantage
Authors: Khuan Hendri , Bambang  , Milla Marlina  , Aisyah Solehati
Published: September 2023

This study aims to uncover the secrets of strategic business planning of startups in West Java, Indonesia, and its relationship with sustainable growth and competitive advantage. Through quantitative analysis of survey data from various startups, this study investigates the relationship between strategic planning practices, resource allocation, sustainable growth, and competitive advantage. The findings show that strategic planning practices and resource allocation are significantly correlated with sustainable growth and competitive advantage. These insights contribute to a deeper understanding of the dynamics of startups in the entrepreneurial ecosystem in West Java, providing valuable guidance for startups, policymakers, investors, and academics.
Studi Kasus Sengketa Pulau Pasir di Laut Timor Antara Australia dan Indonesia
Authors: Akhmad Fadli Rakhmat Ilahi  , Harefa Safarudin
Published: September 2023

Pentingnya wilayah bagi suatu keberadaan negara sering menyebabkan sering terjadinya beberapa perebutan wilayah suatu negara oleh negara lain, wilayah yang di rebut juga bukan hanya Sebagian bahkan bisa juga seluruh bagian dari negara tersebut, dan bukan hanya daratan saja melainkan wilayah laut juga sering kali menjadi sengketa, apalagi negara kita Indonesia yang memiliki ribuan pulau serta laut yang begitu luas menjadikan Indonesia rawan akan sengketa internasional, hal inilah yang menjadikan penulis tertarik dengan sengketa yang dialami Indonesia baru-baru ini sebenarnya sudah lama tetapi muncul lagi masalahnya, yaitu pulau pasir, di sini membahas tentang gagalnya usaha diplomasi Indonesia serta dampak yang akan di terima Indonesia jika pulau pasir di klaim kepemilikannya oleh Australia, serta bagai mana akhir konflik dan penyelesaian yang baik, di sini penulis menggunakan penelitian kepustakaan karena keterbatasan waktu dan izin, di sini pemerintahan Indonesia gagal melakukan diplomasi dalam perjanjian Perth 1977 dan di situ memutuskan bahwa pulau pasir sudah merupakan milik dari Australia, namun hingga saat ini perjanjian tersebut belum ter ratifikasi.
Implications of Islamic Law in Business Dispute Resolution: A Qualitative Approach to Muslim Entrepreneurs
Authors: Evra Willya
Published: September 2023

This research study explores the implications of Islamic law (Sharia) in the settlement of business disputes among Muslim entrepreneurs in West Java, Indonesia. Using a qualitative research approach, this study explores how Islamic principles are integrated into decision-making processes and conflict resolution strategies. Through thematic analysis of the interviews, this study uncovers themes of ethical integration, peaceful resolution through mediation (Sulh), the mediating role of religious principles, and the challenge of harmonizing Sharia with the legal system. These findings contribute to an understanding of the interaction between Islamic values and modern business practices, providing insight into ethical considerations and cultural sensitivity in dispute resolution.
Rekonstruksi Penelitian Hukum Administrasi Negara melalui Pendekatan Bibliometrik: Sebuah Tinjauan Komprehensif tentang Perkembangan dan Kontribusi Literatur
Authors: Kurniawati Rina , Arief Fahmi Lubis  , Samuel Indrayana  , Bagus Ananda Kurniawan  , Diana Rahmawati
Published: September 2023

Penelitian ini menggunakan pendekatan bibliometrik, terutama dengan menggunakan perangkat lunak VOSviewer, untuk meninjau secara komprehensif perkembangan dan kontribusi literatur Hukum Administrasi Negara. Hukum Administrasi Negara, sebuah aspek penting dari tata kelola pemerintahan publik dan sistem hukum, mencakup peraturan, prinsip, dan prosedur yang mengatur tindakan administratif. Analisis bibliometrik memetakan lintasan penelitian, mengidentifikasi penulis dan karya-karya yang berpengaruh, mengungkapkan tren tematik, dan menawarkan wawasan ke dalam lanskap intelektual. Melalui jaringan kepenulisan bersama, analisis kutipan bersama, pemetaan kemunculan bersama kata kunci, dan analisis konten kualitatif, penelitian ini menyoroti evolusi bidang ini dan implikasinya terhadap tata kelola pemerintahan dan masyarakat.
Tinjauan Hukum Pidana: Eksplorasi Bibliometrik tentang Perkembangan dan Inovasi Riset
Authors: Suyanto
Published: September 2023

Makalah penelitian ini menyajikan eksplorasi bibliometrik yang komprehensif mengenai perkembangan dan inovasi penelitian hukum pidana. Dengan menganalisis beragam publikasi ilmiah dari tahun 1979 hingga saat ini, penelitian ini menggunakan teknik bibliometrik dan analisis VOSviewer untuk mengungkap tren utama, pola kolaborasi, dan pergeseran tematik di dalam bidang ini. Hasilnya menunjukkan adanya beberapa kelompok topik penelitian yang berbeda, termasuk peradilan pidana, hukum internasional, strategi pertahanan, dan mekanisme pencegahan. Penulis yang produktif, lembaga-lembaga yang berpengaruh, dan kolaborasi interdisipliner diidentifikasi, yang mencerminkan sifat multidisipliner dari keilmuan hukum pidana. Analisis kemunculan kata kunci menyoroti keprihatinan yang berkembang di bidang ini, mulai dari hukum pidana internasional hingga isu-isu kriminalisasi dan pencegahan. Penelitian ini memberikan kontribusi pemahaman yang komprehensif tentang bagaimana hukum pidana beradaptasi dengan perubahan sosial, kemajuan teknologi, dan tantangan yang muncul, sehingga menginformasikan arah penelitian di masa depan dan pertimbangan kebijakan.
ฟิล์มเป่าที่มีรูพรุนขนาดเล็กจากพอลิเมอร์ผสมระหว่างพอลิโพรพิลีนและพอลิเอทิลีน
Authors:   , อนิลบล ปวีณา
Published: September 2023

งานวิจัยนี้มุ่งเน้นศึกษาประสิทธิภาพการใช้พอลิเมอร์ผสมระหว่างพอลิโพรพิลีน (PP) และพอลิเอทิลีน (PE) เป็นวัตถุดิบในการขึ้นรูปฟิล์มที่มีรูพรุนขนาดเล็ก โดยศึกษาจากพอลิโพรพิลีน 2 เกรด คือ PP1 และ PP2 ซึ่งมีดัชนีการไหล ~2.0-2.4 กรัม/10 นาที และเลือกใช้พอลิเอทิลีนที่มีดัชนีการไหลที่สูงต่างกัน 4 ชนิดคือ พอลิเอทิลีนชนิดความหนาแน่นสูง (HDPE) พอลิเอทิลีนชนิดความหนาแน่นต่ำ (LDPE) พอลิเอทิลีนชนิดความหนาแน่นต่ำเชิงเส้น (LLDPE) และพอลิเอทิลีนแว๊กซ์ (PE wax) มีการเตรียมฟิล์มเป่า PP/PE ด้วยสัดส่วนผสมโดยน้ำหนักของพอลิโพรพิลีนต่อพอลิเอทิลีนเป็น 100/0 85/15 และ 60/40 โดยใช้เครื่องเป่าฟิล์มของแล็บเทค รุ่น LF-400-COEX (สัดส่วนความยาวต่อความโตของช่องทางการไหลคือ 30 และ เส้นผ่านศูนย์กลางของดายคือ 30 มม.) ศึกษาอิทธิพลของการเย็นตัวของฟิล์ม และระดับการดึงยืดฟิล์มที่ส่งผลต่อสมบัติด้านแรงดึง สัณฐานวิทยา และระดับรูพรุนของฟิล์ม จากผลการทดลองพบว่า ฟิล์ม PP และฟิล์ม PP/HDPE สามารถเตรียมให้มีระดับรูพรุนมากกว่าร้อยละ 20 ได้ อย่างไรก็ตามภาวะของการหล่อเย็น และการดึงยืดที่ได้ไม่เหมาะสม ส่งผลเชิงลบต่อระดับรูพรุน ภาพจากกล้องจุลทรรศน์อิเล็กตรอนแบบส่องกราด แสดงให้เห็นถึงรูพรุนที่มีลักษณะวงรีเมื่อเพิ่มระดับดึงยืดที่สูง อย่างไรก็ตามความเป็นรูพรุนของฟิล์มเหล่านี้ซึ่งวัดจากการดูดซับน้ำมันนั้นมีแนวโน้มที่ต่ำกว่าฟิล์มที่เตรียมด้วยระดับการดึงยืดที่น้อยกว่า นอกจากนี้สมบัติด้านแรงดึงนั้นลดลงเมื่อเติมพอลิเอทิลีนผสมกับพอลิโพรพิลีน ยกเว้นฟิล์ม PP1/HDPE ซึ่งมีมอดุลัสของแรงดึงและร้อยละการยืดสูงสุดมากกว่าฟิล์ม PP1 ในขณะที่ความเป็นรูพรุนของฟิล์ม PP สามารถทำได้สูงถึงร้อยละ 25 ระดับความเป็นรูพรุนของฟิล์ม 60/40 PP/HDPE มีค่าที่สูงกว่า
Pengaruh Positif Penggunaan Bingkai Diskon Terhadap Reputasi Merek, Citra Merek, Dan Minat Beli Ulang Di Toko Online Shopee
Authors: Lisda Anisa Putri  , Albari Albari
Published: September 2023

The growth of e-commerce is increasing over time, it can be seen by the number of e-commerce that have sprung up. Shopee is one of the many e-commerce in Indonesia which has become the e-commerce with the most users in Indonesia. As the largest e-commerce company, marketing strategies play an important role in selling products, introducing products, and attracting consumers. This study aims to determine how influential discount framing as one of the marketing strategy used by Shopee has on brand reputation and brand image. In addition, it also determines whether consumer repurchase interest occurs due to these three factors. This research using a sample of 166 respondents spread across Indonesia. The sampling Technique uses convenience sampling. The analysis using the SEM method and processed using AMOS 24.0. The result of this study showed that there was a positive and significant influence between variables discount frame and brand image, discount frame and brand reputation, brand reputation and brand image, and brand image and repurchase intention. Meanwhile, the discount frame and brand reputation variables obtained results that were not significant in influencing the repurchase intention variable.
Conociendo a las estrellas del universo R: comunidad R, intercambiar y aprender
Authors: Saibene Yanina Bellini , Bellini Alejandra , Casalla Lucio , LaZerte Steffi , Nicolini Juan Pablo Ruiz , Tiscornia Pablo
Published: September 2023

Esta es la primera entrega de nuestra serie de entrevistas

“Conociendo a las estrellas del universo R”

. Tenemos como objetivo introducir los grupos de trabajo y las personas que están detrás del desarrollo del software y paquetes que muchos utilizamos y que se encuentran disponibles en

R-Universe

. Queremos resaltar y conocer diferentes proyectos alrededor del mundo, el trabajo que hacen, sus procesos y usuarios.
Interactive maps with polygons using R, Geojson, and Github
Authors: Chamberlain Scott
Published: September 2023

Previously on this blog we have discussed making geojson maps and uploading to Github for interactive visualization with USGS BISON data, and with GBIF data, and on my own personal blog. This is done using a file format called

geojson

, a file format based on JSON (JavaScript Object Notation) in which you can specify geographic data along with any other metadata.
Creando Tu R-universe
Authors: Saibene Yanina Bellini
Published: September 2023

Durante useR!
New package graphql: A GraphQL Query Parser
Authors: Ooms Jeroen
Published: September 2023

The new ropensci graphql package is now on CRAN.
From occurrence data to interactive maps on the web
Authors: Chamberlain Scott
Published: September 2023

We have a number of packages for getting species occurrence data: rgbif and rbison. The power of R is that you can pull down this occurrence data, manipulate the data, do some analyses, and visualize the data - all in one open source framework. However, when dealing with occurrence data on maps, it is often useful to be able to interact with the visualization.
Organisation IDs for scholarly communications: where next?
Authors: Demeranville Tom
Published: September 2023

On April 17, as part of FORCE 2016 in Portland Oregon, Crossref, and THOR partners DataCite and ORCID convened a workshop to discuss the current state of the art in organisation identifiers. We discussed this issue previously in a post on the ORCID blog, and we’re pleased to report back to you all that the workshop was a big success.
AntWeb - programmatic interface to ant biodiversity data
Authors: Ram Karthik
Published: September 2023

Data on more than 10,000 species of ants recorded worldwide are available through from California Academy of Sciences’ AntWeb, a repository that boasts a wealth of natural history data, digital images, and specimen records on ant species from a large community of museum curators.
Usos interesantes de censo2017 un año después de su publicación
Authors:   The rOpenSci Team
Published: September 2023

Resumen Este artículo trata sobre los usos sorprendentes que he observado y las preguntasque recibo sobre el paquete R censo2017, una herramienta paraacceder a los datos del censo chileno de 2017, que he recibido desde que fue revisado por paresa través de rOpenSci hace un año.
Canales de comunicación de rOpenSci: Twitter
Authors: Saibene Yanina Bellini , LaZerte Steffi
Published: September 2023

Twitter es una de las plataformas y redes sociales preferidas por la comunidad de R y por las comunidades de datos, ciencia abierta e investigación. Desde el comienzo de rOpenSci hemos utilizado Twitter para conectarnos con nuestra comunidad y otras comunidades similares, para compartir lo que hacemos y para formar parte de las conversaciones en torno a los temas importantes para nuestra misión.
Advanced Image-Processing in R with Magick, Part I
Authors: Ooms Jeroen
Published: September 2023

The new magick package is an ambitious effort to modernize and simplify high-quality image processing in R. It wraps the ImageMagick STL which is perhaps the most comprehensive open-source image processing library available today. The ImageMagick library has an overwhelming amount of functionality. The current version of Magick exposes a decent chunk of it, but being a first release, documentation is still sparse.
A drat repository for rOpenSci
Authors: Boettiger Carl
Published: September 2023

We’re happy to announce the launch of a CRAN-style repository for rOpenSci at http://packages.ropensci.org This repository contains the latest nightly builds from the master branch of all rOpenSci packages currently on GitHub.
rOpenSci awarded 180K from The Sloan Foundation
Authors: Ram Karthik
Published: September 2023

Today we are pleased to announce that rOpenSci has been awarded a generous 180K grant from the Alfred P. Sloan foundation. This funding will allow us to develop a whole new suite of tools and provide scientists with general purpose toolkits to access various kinds of scientific data. We will also be traveling a whole bunch this year and running workshops at several conferences and universities.
Community calls
Authors: Chamberlain Scott
Published: September 2023

Key to the success of rOpenSci is our community and we want to hear more regularly from our members, and foster new interactions among the group. In addition, community calls are a way for us to give important updates, and get feedback on them. We tentatively plan on doing community calls once per month. The format of rOpenSci community calls could be of various types.
The challenge of combining 176 otherpeoplesdata to create the Biomass And Allometry Database
Authors: Falster Daniel , FitzJohn Rich , Duursma Remko , Barneche Diego
Published: September 2023

Despite the hype around “big data”, a more immediate problem facing many scientific analyses is that large-scale databases must be assembled from a collection of small independent and heterogeneous fragments – the outputs of many and isolated scientific studies conducted around the globe. Collecting and compiling these fragments is challenging at both political and technical levels.
Making maps of climate change
Authors: Hart Ted
Published: September 2023

A recent video on the PBS Ideas Channel posited that the discovery of climate change is humanities greatest scientific achievement. It took synthesizing generations of data from thousands of scientists, hundreds of thousands (if not more) of hours of computer time to run models at institutions all over the world. But how can the individual researcher get their hands of some this data?
A task view for interacting with the web from R
Authors: Chamberlain Scott
Published: September 2023

There is an increasing set of R packages for interacting with the web from R, whether it be the low level tools to interact with the web via http (see RCurl and httr), parsing data from the web (like RJSONIO and XML), or wrappers to web APIs that provide data (like twitteR). Most of you probably know about CRAN Task Views that aggregate information about R packages and functions on a particular subject area into a simple web page.
ORCID Integration Series: PANGAEA
Authors: Stocker Markus
Published: September 2023

This is the first in a series of posts describing how THOR partners have recently integrated ORCID in their disciplinary data repositories. This post describes ORCID integration in PANGAEA, the Data Publisher for Earth & Environmental Science. PANGAEA is rolling out a new version of its website. Developers and designers are currently ironing out a few remaining open issues. The release is expected for autumn 2016.
Highlighting text in text mining
Authors: Chamberlain Scott
Published: September 2023

rplos is an R package to facilitate easy search and full-text retrieval from all Public Library of Science (PLOS) articles, and we have a little feature which aren’t sure if is useful or not. I don’t actually do any text-mining for my research, so perhaps text-mining folks can give some feedback. You can quickly get a lot of results back using rplos, so perhaps it is useful to quickly browse what you got.
Contributor Information in DataCite Metadata
Authors: Fenner Martin
Published: September 2023

The Force11 Joint Declaration of Data Citation Principles highlight the importance of giving scholarly credit to all contributors: The EC-funded THOR project that DataCite is involved in addresses these issues, and I have summarized the findings of one of our first reports in aprevious blog post.
New fiscal sponsorship agreement with NumFocus foundation
Authors: Ram Karthik
Published: September 2023

I’m very pleased to announce that rOpenSci has signed a comprehensive fiscal sponsorship agreement with the NumFocus foundation, a 501(c)3 nonprofit that supports R&D for open source scientific software projects.
Webinar Data – Article linking services
Authors: Duine Maaike
Published: September 2023

On Thursday March 17, 3pm-4pm CET, OpenAIRE, THOR, Datacite, and ORCID will organise a one hour webinar on data – article linking services. Project OpenAIRE aims to support the implementation of Open Science in Europe and will demonstrate during the webinar how they collaborate with DataCite and CrossRef to establish a sustainable e-infrastructure for researchers.
The THOR Ambassador Programme is GO!
Authors: Demeranville Tom
Published: September 2023

Would you like to help others enjoy the full power of persistent identifiers?  A core component of the THOR project is two-way community involvement and with that in mind we’re happy to be launching the THOR project Ambassador Programme. THOR ambassadors will help shape the way we look at the persistent identifier landscape, influence new services, and help us understand where we are doing well and where we could do better.
Knowledge hub set to soft-launch, join our webinar on January 28th!
Authors: Demeranville Tom
Published: September 2023

We’re really excited to announce the upcoming soft-launch of the THOR knowledge hub. A skeleton resource at the moment, the knowledge hub will evolve into the first point of call for information about persistent identifiers. We’d love to show you what we’ve built so far, share our plans for the hub and gather your feedback, suggestions and contributions.
Caching API calls offline
Authors: Chamberlain Scott
Published: September 2023

I’ve recently heard the idea of “offline first” via especially Hood.ie. We of course don’t do web development, but primarily build R interfaces to data on the web. Internet availablility is increasinghly ubiqutous, but there still are times and places where you don’t have internet, but need to get work done.
La Historia de censo2017, el Primer Paquete de rOpenSci Revisado en Español
Authors: Sepúlveda Mauricio Vargas
Published: September 2023

Resumen censo2017 es un paquete en R diseñado paraorganizar los archivos Redatam

1

proporcionados por el Instituto Nacional de Estadísticas de Chile en formatoDVD

2

. Este paquete fue inspirado por citesdb(Noam Ross, 2020) y taxadb(Carl Boettiger et al, 2021).Esta entrada trata sobre este paquete, elproblema que resuelve, cómo usarlo, y el hecho de que el paquete y su proceso derevisión se hicieron íntegramente enespañol.El
Knowledge Exchange Workshop
Authors: Demeranville Tom
Published: September 2023

Researcher Identifiers – National approaches to ORCID and ISNI implementation Members of the THOR team spent Monday and Tuesday attending the “Researcher Identifiers – National approaches to ORCID and ISNI implementation” workshop in London. The workshop focused on person identifiers, with the bulk of discussion about the use of ORCID, CRIS systems, ISNI, federated identity and organisational identifiers.
Emergence of Dendritic Cells in the Myocardium after Acute Myocar­dial Infarction - Implications for Inflammatory Myocardial Damage
Authors:   Clinic of Internal Medicine I, Department of Cardiology, University Hospital Jena, Jena, Germany, Schubert Katja ,   Clinic of Internal Medicine I, Department of Cardiology, University Hospital Jena, Jena, Germany, Hausmann Roland ,   Department of Forensic Medicine, University Basel, Switzerland, Dietel Barbara , Cicha Iwona , Daniel Werner G. , Garlichs Christoph D. , Stumpf Christian ,   Medical Clinic II, University Hospital Erlangen, Erlangen, Germany
Published: September 2023

Dendritic cells (DC) are crucial for T cell mediated immune responses. Recently, we observed a significant decrease in circulating myeloid DC precursors in patients with acute myocardial infarction (AMI). The aim of the present study was to investigate whether myeloid DC are present in infarcted myocardium. Myocardial specimens of 10 patients with AMI and 7 accident victims (controls) were collected after autopsy. In immunostainings the presence of DC (CD209+, fascin+), T cells (CD3+), macrophages (CD68+), and HLA-DR expression was analyzed. Significantly higher numbers of CD209+-DC (97 vs. 44 cells/0.25 mm2, p=0.03), fascin+-DC (54 vs. 8 cells/0.25 mm2, p=0.02), T cells (27 vs. 6 cells/0.25 mm2, p=0.02), and macrophages (44 vs. 6 cells/0.25 mm2, p=0.01) associated with high HLA-DR expression were detected in infarcted myocardium. Frequent colocalizations of DC and T cells were observed. In occluded coronary arteries numerous DC, T cells, macrophages and high HLA-DR expression were found. We show that DC are present in infarcted myocardium after AMI. High HLA-DR expression and the colocalization with T cells suggest that they might trigger an immune response leading to further myocardial damage.
Metastatic Male Ductal Breast Cancer Mimicking Obstructing Primary Colon Cancer
Authors:   Division of Surgical Oncology, Department of General Surgery, Albany Medical Center Hospital, 43 New Scotland Avenue, Albany, New York, USA, Hena Muhammad , Koleilat Issam , Syal Anil
Published: September 2023

Male breast cancer comprises only about 1% of all breast cancers. Commonly, sites of metastases include the central nervous system, lungs, bones, and even liver. In females, extrahepatic gastrointestinal metastases are unusual but have been reported with various clinical presentations. We are reporting the first case of a male patient with a history of ductal breast carcinoma that developed colonic metastasis and presented with mechanical large bowel obstruction masquerading as primary colon cancer.
Non-Markovian Population Dynamics: Does it Help to Optimize the Chemotherapeutic Strategy?
Authors:   N.N.Semenov Institute for Chemical Physics, Russian Academy of Sciences, Kosygin St.4, Moscow, Russia, Kuznetsov Dmitry A. , Amirshahi Nima ,   N.N.Semenov Institute for Chemical Physics, Russian Academy of Sciences, Kosygin St.4, Moscow, Russia, Makarov Andrey V. ,   Department of Medicinal Nanobiotechnologies, N.I.Pirogov Russian State Medical University, Ostrovityanov St.1, Moscow, Russia, Fallahi Majid ,   Department of Molecular and Experimental Hemamatology, Oncology and Immunology, Federal Research Center of Pediatric Hematology, Oncology and Immunology, Leninsky prospect 117, Moscow, Russia, Roumiantsev Sergey A. ,   Department of Clinical Hematology, N.I.Pirogov Russian State Medical University, Ostrovityanov St.1, Moscow, Russia, Kardashova Karina S. ,   Department of Fundamental and Applied Neurobiology, V.P.Serbsky Institute for Social and Forensic Psychiatry, Kropotkinsky Pereulok, 23, Moscow, Russia
Published: September 2023

A non-Markovian theory of population dynamics is to simulate the anti-cancer drug distribution between malignant and the hosting normal cell pools. The model takes into account both the cell life span and the proliferation rate differences. This new simulation approach looks promising for its potential to optimize a chemotherapeutic strategy by choosing the scheme with a higher degree of the drug-tumor selectivity. The pre-test designed simulation mode fits nicely the experimental data on Porphylleren-MC16 (PMC16) pharmacokinetics patterns including the allometric plots revealed for this novel medicinal nanoparticle possessing some anti-cancer potential and intervening into the oxygen-independent ATP production mechanisms.
Validated Stability indicating Spectrophotometric Method for the Determination of Acetazolamide in Dosage Forms through Complex Formation with Palladium (II)
Authors:   Department of Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt, El-Enany N. , Walash M. I. , El-Brashy A. , Wahba M. E. K.
Published: September 2023

A simple and sensitive spectrophotometric method was developed for the determination of acetazolamide (ACM) in pure form and pharmaceutical preparations. The proposed method is based on the complex formation of acetazolamide with Palladium (II) chloride in acetate buffer pH 5.4 and measuring the absorbance at 308 nm. The absorbance-concentration plot was rectilinear over the concentration range of 5-70 μg/ml with a minimum detection limit (LOD) of 0.98 μg/ml, limit of quantification (LOQ) of 2.96 μg/ml, and a molar absorptivity ζ = 2.7 × 103 L/mol.cm. The factors affecting the absorbance of the formed complex were carefully studied and optimized. The composition of the complex as well as its stability constant was also investigated. The proposed method was applied for the determination of acetazolamide in its tablets and the results obtained were favorably compared with those obtained using the official method. A proposal of the reaction pathway was postulated.
Immune System as a Sensory System
Authors:   Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA, Dozmorov Igor M. , Dresser D.
Published: September 2023

As suggested by the well-known gestalt concept the immune system can be regarded as an integrated complex system, the functioning of which cannot be fully characterized by the behavior of its constituent elements. Similar approaches to the immune system in particular and sensory systems in general allows one to discern similarities and differences in the process of distinguishing informative patterns in an otherwise random background, thus initiating an appropriate and adequate response. This may lead to a new interpretation of difficulties in the comprehension of some immunological phenomena.
In Vitro and In Vivo Studies on the Effects of Bone Morphogenetic Protein-7 on Human Kidney and Lung Tumor Cells
Authors:   Department of Biochemistry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA, Yeh Lee-Chuan C.
Published: September 2023

Breast, kidney, lung, and prostate cancers are among the human cancers that show high propensity to form bone metastasis. Bone morphogenetic protein (BMP) -2 and -7 are two members of the BMP superfamily which show the most potent biological activity in stimulating bone differentiation and repair. These proteins have been used in clinical treatment of orthopedic diseases and have also been studied in different types of cancer. We report here detection of mRNA coding for three type I and one type II BMP receptors in G-402 kidney tumor cells and A-549 lung tumor cells, suggesting that these cells are responsive to BMPs. We then observed that BMP-7 inhibited cell proliferation of both cell lines in a protein concentration dependent manner in vitro. Additionally, when BMP-7-treated cells were implanted into the flank region of male nude mice, smaller tumors, compared to those formed with the untreated cells, were observed. Histological analysis showed that the masses formed at the site of implantation displayed significantly less number of tumors than the control and exhibited significant ectopic bone formation. These findings raise the possibility of BMP-7 as a therapeutic agent for kidney and lung cancers.
Cyclic Peptidomimetic Lead Compounds to Reduce Neurotoxicity and Associated Oxidative Stress in Alzheimer's Disease
Authors:   Department of Chemistry, University Institute of Engineering and Technology, CSJM University, Kanpur, India, Yadav Arpita , Banerjee Antara
Published: September 2023

Cyclic peptidomimetic compounds have been investigated utilizing ab initio Hartree Fock molecular orbital calculations. Prospective use of these ionophores as curative drugs for Alzheimer's disease has been investigated by considering their metal toxicity removal efficiency. A (2,4,2,4) system that is, ((gly-et)-(ala-gly-gly-et))2 with CH2NH backbone is predicted to undergo low conformational reorganization in presence of Zn2+ ion with moderate electrostatic stabilization of ion. Conformation of this system and molecular weight render it suitable to be a lead compound for metal toxicity removal drugs required in AD.
Feasibility Evaluation of Detecting Hydroxymethylphosphine Oxide In Vivo by 31P-MRS
Authors:   Department of Pharmaceutical Sciences, The University of Oklahoma College of Pharmacy, 1110 N. Stonewall Avenue, Oklahoma City, Oklahoma, USA, Gali Hariprasad , Doblas Sabrina , Towner Rheal A. ,   Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, 825 NE 13th street, Oklahoma City, Oklahoma, USA, Pathuri Gopal ,   Department of Pharmaceutical Sciences, The University of Oklahoma College of Pharmacy, 1110 N. Stonewall Avenue, Oklahoma City, Oklahoma, USA
Published: September 2023

Application of organophosphorus compounds in biomedicine is attractive because the 31P nucleus is very amenable to study by nuclear magnetic resonance (NMR) techniques, particularly, by in vivo 31P magnetic resonance spectroscopy (31P-MRS). The water-soluble organophosphorus compounds that are non-toxic, exhibit metabolic stability, and show a unique resonance peak in 31P NMR spectroscopy, which could be ideal to be used as probes for 31P-MRS. Here we evaluated the in vivo feasibility of potentially using a hydroxymethylphosphine oxide as a novel probe for 31P-MRS studies using tris(hydroxymethyl)phosphine oxide (THPO) as an example. THPO was synthesized, injected in the normal CF1 mice, and 31P spectra were acquired before and after injection with the coil located on the regions of interest. The NMR signal from the region of interest appeared within one minute of THPO injection. The compound was stable in vivo as no metabolites of THPO were observed. No toxicity was observed after THPO injection in mice. The peak concentrations of THPO in liver and kidney were reached within 15 min and 60 min respectively. THPO was excreted exclusively in urine without undergoing any metabolism indicating that it is very stable under in vivo conditions. These initial studies in normal CF1 mice clearly demonstrate that THPO possess the essential characteristics required for a potential MRS probe. Based on the current preliminary results, we suggest that HMPs, when incorporated into targeted drugs (peptides, proteins, antibodies, etc.), may serve as novel 31P probes for monitoring the drug distribution in vivo by MRS.
Hypolipidemic and Renal Functionality Potentials of the Hexane Extract Fractions of Elephantopus Scaber Linn
Authors:   P.G and Research Department of Biotechnology and Bioinformatics, HolyCross College, Trichy, India, Daisy P. , Priya Cecilia Edel
Published: September 2023

Background: Abnormalities in lipid profile are one of the most common complications in diabetes mellitus. In STZ -induced diabetic rats, the rise in blood glucose is accompanied by a disturbance in lipid profile. Further still is the disturbance in the renal functions which includes abnormality in the serum urea,protein and creatinine levels The aim of the present study is to prove the hypolipidemic and the renal functionality effect of the root of Elephantopus scaberLinn. Procedure: Fractions obtained from crude extracts of hexane prepared from the root of Elephantopus scaberLinn. were administered to white albino rats at a dose of 0.15g/Kg bwt for a period of 30 days to prove its hypolipidemic effect on a long term basis which is proved to be irreversible as the plant is reported to have regenerative property.Findings: The extract produced a significant (p<0.001) dose-dependent decrease in the levels of total cholesterol (TC), Triacylglycerol (TG), low-density lipoprotein-cholesterol (LDL cholesterol), with a significant increase in the level High-density lipoprotein-cholesterol (HDL) and reporting the restoration in renal functions back to near normal. Conclusion: The fractions of Elephantopus scaberLinn.hexane extractare confirmed to have a hypolipidemic potential and a re-establishment of renal functions.
Spectrofluorimetric and Spectrophotometric Determination of Pregabalin in Capsules and Urine Samples
Authors:   Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Alexandria University, Elmessalah 21521, Alexandria, Egypt, Shaalan Rasha Abdel- Aziz
Published: September 2023

Three new, simple, sensitive and selective spectrofluorimetric and spectrophotometric methods were developed for the determination of the γ-amino-n-butyric acid derivative, pregabalin. Pregabalin as a primary amine reacts with fluorescamine to yield a fluorescent product (Method I), with 2,4-dinitrofluorobenzene (Method II) and 2,3,5,6-tetrachloro-1,4-benzoquinone (Method III) in aqueous alkaline buffered media to form colored products which could be measured spectrophotometrically. The optimum conditions for each reaction were ascertained and the methods were applied for the determination of pregabalin over the concentration range of 20-280 ng mL-1 and 1 - 7 µg mL-1 for spectrofluorimetry and spectrophotometry, respectively with good correlation (≥0.999). The limits of assays detection ranged from 9.6 × 10-4 µg mL-1 to 0.42 µg mL-1 for spectrofluorimetry and spectrophotometry, respectively. The suggested methods were applied to the determination of the drug in capsules. No interference could be observed from the additives listed to be in capsules. Furthermore, the spectrofluorimetric method was extended to the in-vitro determination of pregabalin in spiked urine, interference from endogenous amino acids could be eliminated through selective complexation with copper acetate; the percentage recovery was found to be 98% ± 1.42 (n=6). Co- administered drugs such as chlordiazepoxide, clonazepam, diazepam, nitrazepam and lamotrigine did not interfere with the assay. The methods were validated with respect to linearity, accuracy, precision and robustness. The results obtained were determined to be in good agreement with those obtained using a previously reported method.
Simultaneous Determination of Potassium Clavulanate and Amoxicillin Trihydrate in Bulk, Pharmaceutical Formulations and in Human Urine Samples by UV Spectrophotometry
Authors:   Vardhman Life Sciences Pvt. Ltd., A-7, Sipcot Industrial Complex, Cuddalore (Tamilnadu), India, Gujral Rajinder Singh , Haque Sk Manirul
Published: September 2023

A simple and sensitive UV spectrophotometric method was developed and validated for the simultaneous determination of Potassium Clavulanate (PC) and Amoxicillin Trihydrate (AT) in bulk, pharmaceutical formulations and in human urine samples. The method was linear in the range of 0.2–8.5 µg/ml for PC and 6.4–33.6 µg/ml for AT. The absorbance was measured at 205 and 271 nm for PC and AT respectively. The method was validated with respect to accuracy, precision, specificity, ruggedness, robustness, limit of detection and limit of quantitation. This method was used successfully for the quality assessment of four PC and AT drug products and in human urine samples with good precision and accuracy. This is found to be simple, specific, precise, accurate, reproducible and low cost UV Spectrophotometric method.
The Search for a Common Alphabet in the Turkic Republics and Obstacles
Authors: Can Mehmet
Published: September 2023

The Turkish nation, with a current population exceeding 250 million, experienced significant political and geographical fragmentation in the 19th and 20th centuries, particularly in the East-West divide. Warfare, occupation, and cultural absorption all contributed to this fragmentation. Their alphabet changed several times over time, and their language encountered difficulties. As a result, their communication, and ties with one another degraded to the point that they appeared unable to effectively communicate, agree, or collaborate. The existing links between the Turkish World and Turkey were mostly severed during the Soviet era. However, with the fall of the Soviet Union and the subsequent declarations of independence by new Turkic Republics, these links were quickly restored. Today, Turkish states cooperate closely in various fields, engaging in significant joint projects, particularly through organizations like TIKA (Turkish Cooperation and Coordination Agency). One notable initiative is the quest for a "Common Alphabet," aiming to foster better communication and unity among Turkish-speaking communities
Pengembangan Media Pembelajaran Bola Rahasia pada Kemahiran Menulis Teks Prosedur Siswa Kelas VII Sekolah Menengah Pertama Negeri 1 Tanjungpinang
Authors: Salmiati Salmiati , Elfitra Legi , Kurmalasari Tety
Published: September 2023

Studi ini bertujuan untuk mengembangkan media pembelajaran bola rahasia untuk kemampuan menulis teks prosedur pada siswa kelas VII di SMP Negeri 1 Tanjungpinang. Metode yang digunakan dalam studi ini adalah model pengembangan 4-D yang terdiri dari Define, Design, Develop, dan Disseminate. Namun, dalam studi ini, para peneliti hanya melakukan pengembangan. Data dari studi ini diperoleh dari validasi ahli media dan ahli materi, yang kemudian diuji pada delapan siswa untuk kelompok kecil dan 26 siswa untuk kelompok besar. Penilaian ahli media dan ahli materi meliputi kelayakan konten, kelayakan bahasa, dan kelayakan presentasi. Hasil penilaian dari ahli media memiliki rata-rata 98% dengan kualifikasi sangat valid, sedangkan hasil penilaian dari ahli materi memiliki rata-rata 82% dengan kualifikasi sangat valid. Dalam studi lembar praktik siswa, kelompok kecil dengan rata-rata 91% memiliki kualifikasi sangat praktis, dan kelompok besar dengan rata-rata 83% memiliki kualifikasi sangat praktis. Berdasarkan uji validitas dan praktikabilitas media, bola rahasia layak menjadi media pembelajaran dengan kualifikasi yang valid dan praktis yang dapat digunakan sebagai media pembelajaran dalam pembelajaran Bahasa Indonesia.
Implementasi Standar Akuntansi Keuangan Entitas Mikro Kecil Dan Menengah (SAK EMKM) Terhadap Laporan Keuangan
Authors: Yolanda Bahri Dinda , Epi Yus , Hariyanti Siregar Irma
Published: September 2023

Usaha Mikro Kecil dan Menengah atau yang dikenal dengan istilah UMKM yang diakui sebagai salah satu penyumbang kontribusi yang nyata bagi perekonomian nasional Indonesia, selain itu UMKM juga disebut sebagai salah satu penopang pertumbuhan ekonomi di Indonesia. Bagaimana penyusunan laporan keuangan berdasarkan Standar Akuntansi Keuangan Entitas Mikro Kecil dan Menengah (SAK EKM) pada Barbershop UNCLE G Medan ? Tidak adanya laporan keuangan pada UMKM Barbershop UNCLE G Medan, belum mampu  menyusun laporan keuangan berdasarkan standar akuntansi yang berlaku untuk EMKM. Hal ini dilihat dari bukti pencatatan yang dilakukan yakni hanya mencatat keluar masuknya kas, serta tidak mencatat seluruh aset yang dimiliki. Keadaan yang seperti ini mengakibatkan UMKM Barbershop UNCLE G Medan tidak mampu mengetahui segala macam kegiatan yang bisa mempengaruhi berkurang dan bertambahnya nilai suatu aset yang dimiliki, jumlah kewajiban yang harus dibayar serta total modal yang dimiliki
Pengaruh Perputaran Persediaan Dan Penjualan Terhadap Laba Bersih Pada PT. Central Proteina Prima Tbk
Authors: Ananda Lubis Muhammad Rizky , Siregar Irma Hariyanti
Published: September 2023

Setiap perusahaan pastinya akan menentukan perputaran persediaan yang terjadi selama satu periode serta penjualan yang berpengaruhnya terhadap laba bersih, karena dalam menentukan perputaran persediaan perusahaan akan lebih mengetahui berapa kali efisien perusahaan tersebut berputar dengan melihat dari standar industri yang sudah diberlakukan dan penjualan yang baik akan juga berpengaruh terhadap laba bersih yang baik sebaliknya juga begitu ketika penjualan kurang baik akan juga berpengaruh terhadap laba bersih kurang baik, maka seberapa besar pengaruhnya terhadap kedua perputaran persediaan dan penjualan terhadap laba bersih akan terlihat dengan perhitungan yang digunakan.Latar belakang masalah yang terjadi selama ini bahwa perusahaan tidak mengetahui perhitungan perputaran persediaan dan pengaruh perputaran persediaan serta penjualannya terhadap laba bersih. Berdasarkan permasalahan tersebut, penulis tertarik untuk melakukan penelitian  terhadap kinerja keuangan PT. Central Proteina Prima Tbk untuk menentukan perhitungan  perputaran persediaan dan pengaruh dari perputaran persediaan serta penjualan terhadap laba bersih. Maka penulis mengambil judul “PENGARUH PERPUTARAN PERSEDIAAN DAN PENJUALAN TERHADAP LABA BERSIH PADA PT. CENTRAL PROTEINA PRIMA TBK ”. Dalam penelitian ini penulis menggunakan data primer berupa laporan keuangan dari data mentah perusahaan dimana mengumpulkan data tersebut diperoleh langsung dari perusahaan melalui wawancara, dokumentasi serta studi pustaka. Selanjutnya, data yang diperoleh dianalisis menggunakan analisis kuantitatif perhitungan perputaran persediaan dan penjualan terhadap laba bersih pada PT. Central Proteina Prima Tbk. Hasil dari penelitian ini menunjukkan bahwa pengaruh perputaran persediaan terhadap laba bersih berpengaruh positif dan pengaruh penjualan terhadap laba bersih juga berpengaruh positif serta besarnya pengaruh perputaran persediaan dan penjualan terhadap laba bersih dilihat dari hasilnya berpengaruh positif secara simultan pada PT. Central Proteina Prima Tbk