bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure Legend from Isoangustone A, A Novel Licorice Compound, Inhibits Cell Proliferation by Targeting PI3K, MKK4, and MKK7 in Human Melanoma
Authors: Song Nu Ry , Lee Eunjung , Byun Sanguine , Kim Jong-Eun , Mottamal Madhusoodanan , Park Jung Han Yoon , Lim Soon Sung , Bode Ann M. , Lee Hyong Joo , Lee Ki Won , Dong Zigang
Published: April 2023

PDF file - 68K
Related Article from Get the Fat Out!
Authors: Ignatenko Natalia A. , Gerner Eugene W.
Published: April 2023

Related Article from Get the Fat Out!
Supplementary Methods, Tables 1-3, Figure 1 from Altered Gene Expression in Morphologically Normal Epithelial Cells from Heterozygous Carriers of BRCA1 or BRCA2 Mutations
Authors: Bellacosa Alfonso , Godwin Andrew K. , Peri Suraj , Devarajan Karthik , Caretti Elena , Vanderveer Lisa , Bove Betsy , Slater Carolyn , Zhou Yan , Daly Mary , Howard Sharon , Campbell Kerry S. , Nicolas Emmanuelle , Yeung Anthony T. , Clapper Margie L. , Crowell James A. , Lynch Henry T. , Ross Eric , Kopelovich Levy , Knudson Alfred G.
Published: April 2023

Supplementary Methods, Tables 1-3, Figure 1 from Altered Gene Expression in Morphologically Normal Epithelial Cells from Heterozygous Carriers of BRCA1 or BRCA2 Mutations
Supplementary Table 1 from Dietary Energy Balance Modulates Prostate Cancer Progression in Hi-Myc Mice
Authors: Blando Jorge , Moore Tricia , Hursting Stephen , Jiang Guiyu , Saha Achinto , Beltran Linda , Shen Jianjun , Repass John , Strom Sara , DiGiovanni John
Published: April 2023

PDF file - 48K
Supplementary Table 1 from The Parity-Associated Microenvironmental Niche in the Omental Fat Band Is Refractory to Ovarian Cancer Metastasis
Authors: Cohen Courtney A. , Shea Amanda A. , Heffron C. Lynn , Schmelz Eva M. , Roberts Paul C.
Published: April 2023

PDF file - 73K, Supplementary Table S1. Comparison of the age- and parity-associated immune cell changes in the PSF in the homeostatic state. PSFs from na�ve young adult nulliparous mice (yNP), mature adult nulliparous (aNP) and mature adult parous mice (aP) were harvested by peritoneal lavage. Immune cell subsets were identified by cell surface marker expression using FACS analysis and are presented as a percentage of total CD45+ cells.
Related Article from MUC1 Vaccine for Individuals with Advanced Adenoma of the Colon: A Cancer Immunoprevention Feasibility Study
Authors: Kimura Takashi , McKolanis John R. , Dzubinski Lynda A. , Islam Kazi , Potter Douglas M. , Salazar Andres M. , Schoen Robert E. , Finn Olivera J.
Published: April 2023

Related Article from MUC1 Vaccine for Individuals with Advanced Adenoma of the Colon: A Cancer Immunoprevention Feasibility Study
Supplementary Methods from Epigallocatechin-gallate Suppresses Tumorigenesis by Directly Targeting Pin1
Authors: Urusova Darya V. , Shim Jung-Hyun , Kim Dong Joon , Jung Sung Keun , Zykova Tatyana A. , Carper Andria , Bode Ann M. , Dong Zigang
Published: April 2023

PDF file - 32K
Supplementary Figure 1 from Curcumin Modulates MicroRNA-203–Mediated Regulation of the Src-Akt Axis in Bladder Cancer
Authors: Saini Sharanjot , Arora Sumit , Majid Shahana , Shahryari Varahram , Chen Yi , Deng Guoren , Yamamura Soichiro , Ueno Koji , Dahiya Rajvir
Published: April 2023

PDF file - 620K, miR-203 promoter is hypermethylated in bladder cancer cell lines.
Supplementary Figure Legends from Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin
Authors: Bermudez Yira , Stratton Steven P. , Curiel-Lewandrowski Clara , Warneke James , Hu Chengcheng , Bowden George T. , Dickinson Sally E. , Dong Zigang , Bode Ann M. , Saboda Kathylynn , Brooks Christine A. , Petricoin Emanuel F. , Hurst Craig A. , Alberts David S. , Einspahr Janine G.
Published: April 2023

Supplementary Figure Legends from Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin
Supplemental table 2 from Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate
Authors: Cho Jiyoon , Rho Okkyung , Junco Jacob , Carbajal Steve , Siegel Dionicio , Slaga Thomas J. , DiGiovanni John
Published: April 2023

Supplemental table 2NF-κB, Egr-1, and AP-1 oligonucleotide sequences used for EMSA.
Supplementary Figure S7 from St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling
Authors: Manna Soumen K. , Golla Srujana , Golla Jaya Prakash , Tanaka Naoki , Cai Yan , Takahashi Shogo , Krausz Kristopher W. , Matsubara Tsutomu , Korboukh Ilia , Gonzalez Frank J.
Published: April 2023

Supplementary Figure S7: (A) Food intake of mice on control, 2.5% and 5% St. John's wort extract-supplemented diet at 1 week and 3 week after the introduction of respective diets.
Supplementary Figure S3 from St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling
Authors: Manna Soumen K. , Golla Srujana , Golla Jaya Prakash , Tanaka Naoki , Cai Yan , Takahashi Shogo , Krausz Kristopher W. , Matsubara Tsutomu , Korboukh Ilia , Gonzalez Frank J.
Published: April 2023

Supplementary Figure S3: Putative identification of constituents of St. John's wort extract in the chromatogram of the methanolic extracts by analysis of their fragmentation pattern.
Supplementary Figure S1 from St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling
Authors: Manna Soumen K. , Golla Srujana , Golla Jaya Prakash , Tanaka Naoki , Cai Yan , Takahashi Shogo , Krausz Kristopher W. , Matsubara Tsutomu , Korboukh Ilia , Gonzalez Frank J.
Published: April 2023

Supplementary Figure S1: (A) Representative UPLC-ESITOFMS ion chromatogram of the methanolic extract of St. John's wort extract supplemented diet after 20 days of storage at 4C.
Perspective on This Article from A Randomized Controlled Trial of Celecoxib to Prevent Recurrence of Nonmuscle-Invasive Bladder Cancer
Authors: Sabichi Anita L. , Lee J. Jack , Grossman H. Barton , Liu Suyu , Richmond Ellen , Czerniak Bogdan A. , De la Cerda Jorge , Eagle Craig , Viner Jaye L. , Palmer J. Lynn , Lerner Seth P.
Published: April 2023

Perspective on This Article from A Randomized Controlled Trial of Celecoxib to Prevent Recurrence of Nonmuscle-Invasive Bladder Cancer
Supplementary Material 2 from A Gene Expression Signature from Peripheral Whole Blood for Stage I Lung Adenocarcinoma
Authors: Rotunno Melissa , Hu Nan , Su Hua , Wang Chaoyu , Goldstein Alisa M. , Bergen Andrew W. , Consonni Dario , Pesatori Angela C. , Bertazzi Pier Alberto , Wacholder Sholom , Shih Joanna , Caporaso Neil E. , Taylor Phil R. , Landi Maria Teresa
Published: April 2023

PDF file - 132K, Affymetrix Probesets Differentially Expressed in Stage I Lung Adenocarcinoma Cases Compared to Controls in Current Smokers and All Subjects Combined, Italy, 2002-2005.
Supplementary Table S3 from Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non–Small Cell Lung Cancer and Its Potential as a Circulating Biomarker
Authors: Lou Tzu-Fang , Sethuraman Deepa , Dospoy Patrick , Srivastva Pallevi , Kim Hyun Seok , Kim Joongsoo , Ma Xiaotu , Chen Pei-Hsuan , Huffman Kenneth E. , Frink Robin E. , Larsen Jill E. , Lewis Cheryl , Um Sang-Won , Kim Duk-Hwan , Ahn Jung-Mo , DeBerardinis Ralph J. , White Michael A. , Minna John D. , Yoo Hyuntae
Published: April 2023

Clinical information for tumor and control lung tissues.
Supplementary Table S2 from Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non–Small Cell Lung Cancer and Its Potential as a Circulating Biomarker
Authors: Lou Tzu-Fang , Sethuraman Deepa , Dospoy Patrick , Srivastva Pallevi , Kim Hyun Seok , Kim Joongsoo , Ma Xiaotu , Chen Pei-Hsuan , Huffman Kenneth E. , Frink Robin E. , Larsen Jill E. , Lewis Cheryl , Um Sang-Won , Kim Duk-Hwan , Ahn Jung-Mo , DeBerardinis Ralph J. , White Michael A. , Minna John D. , Yoo Hyuntae
Published: April 2023

Clinical information and common oncogenic mutations for cultured cells.
Supplementary Table 3 from Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques
Authors: Dewi Fitriya N. , Wood Charles E. , Willson Cynthia J. , Register Thomas C. , Lees Cynthia J. , Howard Timothy D. , Huang Zhiqing , Murphy Susan K. , Tooze Janet A. , Chou Jeff W. , Miller Lance D. , Cline J. Mark
Published: April 2023

Immunolocalization of Steroidogenic Enzymes in the Mammary Gland.
Supplementary Figure 2 from Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques
Authors: Dewi Fitriya N. , Wood Charles E. , Willson Cynthia J. , Register Thomas C. , Lees Cynthia J. , Howard Timothy D. , Huang Zhiqing , Murphy Susan K. , Tooze Janet A. , Chou Jeff W. , Miller Lance D. , Cline J. Mark
Published: April 2023

Representative photomicrographs of ERα staining in a transitional duct from a prepubertal animal (A); ERα staining in post-pubertal, differentiated lobuloalveolar tissue (B); ERβ staining in prepubertal transitional duct (C ); and ERβ staining in mature lobuloalveolar tissue (D). Bar = 50 microns.
Supplementary Figure 1 from Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques
Authors: Dewi Fitriya N. , Wood Charles E. , Willson Cynthia J. , Register Thomas C. , Lees Cynthia J. , Howard Timothy D. , Huang Zhiqing , Murphy Susan K. , Tooze Janet A. , Chou Jeff W. , Miller Lance D. , Cline J. Mark
Published: April 2023

Serum isoflavonoid concentrations across the pubertal transition. Levels of circulating total isoflavonoids (genistein + daidzein + equol) were significantly higher in soy-fed monkeys. Values represent LSMs for n=11-17 monkeys/group (bars = SEM). Significant main effects and interactions are indicated in the panel.
Supplementary Figure Legends from Colon Tumors with the Simultaneous Induction of Driver Mutations in APC, KRAS, and PIK3CA Still Progress through the Adenoma-to-carcinoma Sequence
Authors: Hadac Jamie N. , Leystra Alyssa A. , Paul Olson Terrah J. , Maher Molly E. , Payne Susan N. , Yueh Alexander E. , Schwartz Alexander R. , Albrecht Dawn M. , Clipson Linda , Pasch Cheri A. , Matkowskyj Kristina A. , Halberg Richard B. , Deming Dustin A.
Published: April 2023

Supplementary Figure Legends
Supplemental Table 1 and 2 from Prediagnostic Obesity and Physical Inactivity Are Associated with Shorter Telomere Length in Prostate Stromal Cells
Authors: Joshu Corinne E. , Peskoe Sarah B. , Heaphy Christopher M. , Kenfield Stacey A. , Van Blarigan Erin L. , Mucci Lorelei A. , Giovannucci Edward L. , Stampfer Meir J. , Yoon GhilSuk , Lee Thomas K. , Hicks Jessica L. , De Marzo Angelo M. , Meeker Alan K. , Platz Elizabeth A.
Published: April 2023

Supplemental Table 1 and 2. Association of pre-diagnostic BMI, waist circumference, weight change from age 21, total physical activity and vigorous physical activity with telomere length (Supplemental Table 1) and telomere variability (Supplemental Table 2) in cancer cells, stromal cells, basal cells, and luminal epithelial cells in men surgically treated for clinically localized prostate cancer, HPFS.
Supplementary Fig. S5 from Bacterial Prostatitis Enhances 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine (PhIP)–Induced Cancer at Multiple Sites
Authors: Sfanos Karen S. , Canene-Adams Kirstie , Hempel Heidi , Yu Shu-Han , Simons Brian W. , Schaeffer Anthony J. , Schaeffer Edward M. , Nelson William G. , De Marzo Angelo M.
Published: April 2023

Supplementary Figure S5. Mast cell quantification in ventral prostates of control versus PhIP-treated rats (n=2) at week 20 of the study (after 20 weeks of receiving dietary PhIP).
Supplemental Figure S2 from Fenretinide Perturbs Focal Adhesion Kinase in Premalignant and Malignant Human Oral Keratinocytes. Fenretinide's Chemopreventive Mechanisms Include ECM Interactions
Authors: Han Byungdo B. , Li Suyang , Tong Meng , Holpuch Andrew S. , Spinney Richard , Wang Daren , Border Michael B. , Liu Zhongfa , Sarode Sachin , Pei Ping , Schwendeman Steven P. , Mallery Susan R.
Published: April 2023

Supplemental Figure S2. FAK inhibitor II demonstrated negligible invasion-inhibitory effects on EPI and SCC2095sc cell lines.
Supplemental Files from Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Postmenopausal Women
Authors: Fabian Carol J. , Kimler Bruce F. , Phillips Teresa A. , Nydegger Jennifer L. , Kreutzjans Amy L. , Carlson Susan E. , Hidaka Brandon H. , Metheny Trina , Zalles Carola M. , Mills Gordon B. , Powers Kandy R. , Sullivan Debra K. , Petroff Brian K. , Hensing Whitney L. , Fridley Brooke L. , Hursting Stephen D.
Published: April 2023

Supplemental Figure 1: CONSORT diagram for flow of potential and actual subjects enrolled on study. Supplementary Table 1. Demographic and risk information at baseline. Supplementary Table 2. Change in anthropomorphic variables. Supplementary Table 3: Changes in levels of cytokines and adipokines in RPFNA specimens, by Luminex. Supplementary Table 4: Changes in levels of mRNA in RPFNA specimens, by RT-qPCR. Supplementary Table 5: Changes in levels of all peptides and specific phosphopeptides in RPFNA specimens, by Reverse Phase Protein Array.
Supplementary Tables 1-3 from Physical Activity from Early Adulthood and Risk of Prostate Cancer: A 24-Year Follow-Up Study among Icelandic Men
Authors: Hrafnkelsdóttir Soffia M. , Torfadóttir Jóhanna E. , Aspelund Thor , Magnusson Kristjan T. , Tryggvadóttir Laufey , Gudnason Vilmundur , Mucci Lorelei A. , Stampfer Meir , Valdimarsdóttir Unnur A.
Published: April 2023

Supplementary Tables 1-3. Supplemental Table 1. Prostate Cancer risk by combined recreational and occupational physical activity at baseline Supplemental Table 2. Prostate cancer risk by recreational physical activity (RPA), stratified by level of occupational physical activity (OPA) Supplemental table 3. Prostate cancer risk by current recreational physical activity, stratified by level of occupational physical activity
Supplementary Figure 4. from Serum Glycans as Risk Markers for Non–Small Cell Lung Cancer
Authors: Ruhaak L. Renee , Stroble Carol , Dai Jianliang , Barnett Matt , Taguchi Ayumu , Goodman Gary E. , Miyamoto Suzanne , Gandara David , Feng Ziding , Lebrilla Carlito B. , Hanash Samir
Published: April 2023

Receiver operator curves for the glycan combination marker panel stratified by time to diagnosis.
Supplementary Figure 1. from Serum Glycans as Risk Markers for Non–Small Cell Lung Cancer
Authors: Ruhaak L. Renee , Stroble Carol , Dai Jianliang , Barnett Matt , Taguchi Ayumu , Goodman Gary E. , Miyamoto Suzanne , Gandara David , Feng Ziding , Lebrilla Carlito B. , Hanash Samir
Published: April 2023

Box plots representing the summed integrals of one glycan per batch, before and after batch corrections.
Supplementary Methods, Tables 1 - 3 from Red Wine Consumption is Inversely Associated with 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine–DNA Adduct Levels in Prostate
Authors: Rybicki Benjamin A. , Neslund-Dudas Christine , Bock Cathryn H. , Nock Nora L. , Rundle Andrew , Jankowski Michelle , Levin Albert M. , Beebe-Dimmer Jennifer , Savera Adnan T. , Takahashi Satoru , Shirai Tomoyuki , Tang Deliang
Published: April 2023

PDF file - 154KB
Supplementary Table S1 from Enhanced Antitumor Effects of Novel Intracellular Delivery of an Active Form of Menaquinone-4, Menahydroquinone-4, into Hepatocellular Carcinoma
Authors: Setoguchi Shuichi , Watase Daisuke , Matsunaga Kazuhisa , Matsubara Misa , Kubo Yohei , Kusuda Mariko , Nagata-Akaho Nami , Enjoji Munechika , Nakashima Manabu , Takeshita Morishige , Karube Yoshiharu , Takata Jiro
Published: April 2023

Supplementary Table S1. Growth inhibition IC50 values of MK-4 and MKH-DMG against HCC cell lines after treatment with MK-4 or MKH-DMG.
Fig S5 from Loss of BRCA1 in the Cells of Origin of Ovarian Cancer Induces Glycolysis: A Window of Opportunity for Ovarian Cancer Chemoprevention
Authors: Chiyoda Tatsuyuki , Hart Peter C. , Eckert Mark A. , McGregor Stephanie M. , Lastra Ricardo R. , Hamamoto Ryuji , Nakamura Yusuke , Yamada S. Diane , Olopade Olufunmilayo I. , Lengyel Ernst , Romero Iris L.
Published: April 2023

Fig S5 shows co-immunoprecipitation of BRCA1 with HK2.
Fig S1 from Loss of BRCA1 in the Cells of Origin of Ovarian Cancer Induces Glycolysis: A Window of Opportunity for Ovarian Cancer Chemoprevention
Authors: Chiyoda Tatsuyuki , Hart Peter C. , Eckert Mark A. , McGregor Stephanie M. , Lastra Ricardo R. , Hamamoto Ryuji , Nakamura Yusuke , Yamada S. Diane , Olopade Olufunmilayo I. , Lengyel Ernst , Romero Iris L.
Published: April 2023

Fig S1 shows knockdown of BRCA1 and concomitant loss of DNA repair in IOSE cells.
Supplementary Table 4 from JAK3 Variant, Immune Signatures, DNA Methylation, and Social Determinants Linked to Survival Racial Disparities in Head and Neck Cancer Patients
Authors: Guerrero-Preston Rafael , Lawson Fahcina , Rodriguez-Torres Sebastian , Noordhuis Maartje G. , Pirini Francesca , Manuel Laura , Valle Blanca L. , Hadar Tal , Rivera Bianca , Folawiyo Oluwasina , Baez Adriana , Marchionni Luigi , Koch Wayne M. , Westra William H. , Kim Young J. , Eshleman James R. , Sidransky David
Published: April 2023

Cox regression analysis of TCGA Head and Neck Squamous Cell Carcinoma patients (n=279).
Supplementary Table 1 from JAK3 Variant, Immune Signatures, DNA Methylation, and Social Determinants Linked to Survival Racial Disparities in Head and Neck Cancer Patients
Authors: Guerrero-Preston Rafael , Lawson Fahcina , Rodriguez-Torres Sebastian , Noordhuis Maartje G. , Pirini Francesca , Manuel Laura , Valle Blanca L. , Hadar Tal , Rivera Bianca , Folawiyo Oluwasina , Baez Adriana , Marchionni Luigi , Koch Wayne M. , Westra William H. , Kim Young J. , Eshleman James R. , Sidransky David
Published: April 2023

Differences in the frequency of somatic mutations observed in Non-Latino Whites and Black HNSCC patients.
Figure S1 from Prevention of Tobacco Carcinogen-Induced Lung Tumor Development by a Novel STAT3 Decoy Inhibitor
Authors: Njatcha Christian , Farooqui Mariya , Almotlak Abdulaziz A. , Siegfried Jill M.
Published: April 2023

Supplementary Figure 1
Supplemental Table 4 from Calcium-Induced Differentiation of Human Colon Adenomas in Colonoid Culture: Calcium Alone versus Calcium with Additional Trace Elements
Authors: McClintock Shannon D. , Colacino Justin A. , Attili Durga , Dame Michael K. , Richter Aliah , Reddy Anusha R. , Basrur Venkatesha , Rizvi Areeba H. , Turgeon D. Kim , Varani James , Aslam Muhammad N.
Published: April 2023

Down-regulated proteins and associated pathways (by significantly down-regulated proteins)
Supplemental Figure 2 from Calcium-Induced Differentiation of Human Colon Adenomas in Colonoid Culture: Calcium Alone versus Calcium with Additional Trace Elements
Authors: McClintock Shannon D. , Colacino Justin A. , Attili Durga , Dame Michael K. , Richter Aliah , Reddy Anusha R. , Basrur Venkatesha , Rizvi Areeba H. , Turgeon D. Kim , Varani James , Aslam Muhammad N.
Published: April 2023

Reversion of morphological features. At the end of the 30-day incubation period in 1.5 mM calcium (alone or as part of Aquamin®) (a,c), colonoids were re-incubated in medium containing 0.15 mM calcium. Reversion to the undifferentiated phenotype was observed by Day 6 (b,d). Bar=100 μm.
Supplemental Figure 1 from Calcium-Induced Differentiation of Human Colon Adenomas in Colonoid Culture: Calcium Alone versus Calcium with Additional Trace Elements
Authors: McClintock Shannon D. , Colacino Justin A. , Attili Durga , Dame Michael K. , Richter Aliah , Reddy Anusha R. , Basrur Venkatesha , Rizvi Areeba H. , Turgeon D. Kim , Varani James , Aslam Muhammad N.
Published: April 2023

Adenoma colonoid expansion. Individual colonoids from each of the three adenomas were examined under phase-contrast microscopy after 8 and 13 days in culture (under each condition) and photographed. Photoshop CS6 image analysis tool was used to assess the surface area encompassed by individual colonoids and the difference in colonoid size between day-8 and day-13 was used to calculate the growth index (net change between the two time-points). Values shown are means and standard deviations. The number of individual colonoids assessed ranged from n=250 to n=424 for adenoma 282. For adenoma 590, colonoids ranged from n=53 to n=77. For adenoma 584, numbers ranged from n=15 to n=111. Statistical significance was assessed by ANOVA followed by student t-test (two-tailed) for unpaired data. Asterisks indicate significance at p<0.01 level. Insert: Phase-contrast images of the same fields on day-8 and day-13. Colonoids were more differentiated (thick walled, smooth surface and lack of small buds) at Day 13 with calcium 1.5mM as compared to colonoids exposed to calcium 0.15mM. Bar=200 μm.
Supplemental Figure Legends 1 and 2 from Cyclic-GMP–Elevating Agents Suppress Polyposis in ApcMin Mice by Targeting the Preneoplastic Epithelium
Authors: Sharman Sarah K. , Islam Bianca N. , Hou Yali , Singh Nagendra , Berger Franklin G. , Sridhar Subbaramiah , Yoo Wonsuk , Browning Darren D.
Published: April 2023

Supplemental Figure Legends
Figure S2 from Cyclic-GMP–Elevating Agents Suppress Polyposis in ApcMin Mice by Targeting the Preneoplastic Epithelium
Authors: Sharman Sarah K. , Islam Bianca N. , Hou Yali , Singh Nagendra , Berger Franklin G. , Sridhar Subbaramiah , Yoo Wonsuk , Browning Darren D.
Published: April 2023

S2. cGMP-elevating agents regulate homeostasis in intestinal epithelium
Supplemental Methods from Diagnosing Cervical Neoplasia in Rural Brazil Using a Mobile Van Equipped with In Vivo Microscopy: A Cluster-Randomized Community Trial
Authors: Hunt Brady , Fregnani José Humberto Tavares Guerreiro , Schwarz Richard A. , Pantano Naitielle , Tesoni Suelen , Possati-Resende Júlio César , Antoniazzi Marcio , de Oliveira Fonseca Bruno , de Macêdo Matsushita Graziela , Scapulatempo-Neto Cristovam , Kerr Ligia , Castle Philip E. , Schmeler Kathleen , Richards-Kortum Rebecca
Published: April 2023

This file contains more detailed information regarding data collection and management, data analysis, and training and usability of the high-resolution microendoscope (HRME).
Supplemental figures 1-8 from Phospho-Aspirin (MDC-22) Prevents Pancreatic Carcinogenesis in Mice
Authors: Mattheolabakis George , Papayannis Ioannis , Yang Jennifer , Vaeth Brandon M. , Wang Ruixue , Bandovic Jela , Ouyang Nengtai , Rigas Basil , Mackenzie Gerardo G.
Published: April 2023

Fig S1. Phospho-aspirin inhibits the growth of human PC cells. Figure S2. Phospho-aspirin induces apoptosis in human PC cells. Figure S3. Phospho-aspirin induces p53 acetylation in human PC cells and xenografts. Figure S4: PA does not inhibit PGE2 levels in PC cells. Figure S5. Expression levels of phospho-EGFR (p-EGFR) in multiple human PC cells. Figure S6. Phospho-aspirin inhibits EGFR phosphorylation in PC cells. Figure S7. Serum amylase and lipase levels. Figure S8. Representative images of acinar cells explants at day 0 and the resulting metaplasia (day 5).
Supplementary Tables S1-S5 from Effects of Supplemental Calcium and Vitamin D on Expression of Toll-Like Receptors and Phospho-IKKα/β in the Normal Rectal Mucosa of Colorectal Adenoma Patients
Authors: Hodge Rebecca , Mandle Hannah B. , Ray Stephen , Tandon Sonia , Peterson Meaghan , Henry Abigail , Jahan Ferdous A. , Bostick Roberd M. , Baron John A. , Barry Elizabeth L. , Yacoub Rami , Rutherford Robin E. , Seabrook March E. , Fedirko Veronika
Published: April 2023

Table S1. pIKKÎ±/Î², TLR4, and TLR5 Expression in the Full Length of Crypts and Stroma in the Differentiation Zone (Upper 40%) in the Normal-Appearing Rectal Mucosa of the Adjunct Biomarker Study Table S2. pIKKÎ±/Î², TLR4, and TLR5 Expression in the Full Length of Crypts and Stroma in the Proliferation Zone (Lower 60%) of Normal-Appearing Rectal Mucosa of the Adjunct Biomarker Study Participants (n = 105) During the Triala. Table S3. pIKKÎ±/Î², TLR4, and TLR5 Expression in the Ratio (Ï•h) of the Differentiation Zone over the Full Length of the Crypt in Normal-Appearing Rectal Mucosa of the Adjunct Biomarker Study Participants (n = 105) During the Triala. Table S4. The Ratios of (pIKKÎ±/Î²)/TLR4 and (pIKKÎ±/Î²)/TLR5 in the Crypts in the Normal-Appearing Rectal Mucosa of the Adjunct Biomarker Study Participants (n=105)a. Table S5. Geometric Means, 95% CIs, and Proportional Differences in pIKKÎ±/Î², TLR4 and TLR5 Expression in the Full Length of the Crypts and Stroma, by Categories of Baseline Participant Characteristics (n = 105)a.
Supplemental Figure Legends from Chemoprevention of Lung Carcinogenesis by Dietary Nicotinamide and Inhaled Budesonide
Authors: Galbraith Arthur R. , Seabloom Donna E. , Wuertz Beverly R. , Antonides Jennifer D. , Steele Vernon E. , Wattenberg Lee W. , Ondrey Frank G.
Published: April 2023

Supplemental Figure Legends
Figure S2 from Chemoprevention of Lung Carcinogenesis by Dietary Nicotinamide and Inhaled Budesonide
Authors: Galbraith Arthur R. , Seabloom Donna E. , Wuertz Beverly R. , Antonides Jennifer D. , Steele Vernon E. , Wattenberg Lee W. , Ondrey Frank G.
Published: April 2023

Supplemental Figure 2
Supplementary Figure 3 from Methyl Donor Deficiency Blocks Colorectal Cancer Development by Affecting Key Metabolic Pathways
Authors: Hanley Matthew P. , Aladelokun Oladimeji , Kadaveru Krishna , Rosenberg Daniel W.
Published: April 2023

Levels of indoleproprionate (IPA)
Supplemental File 2 from Phase I Trial of Encapsulated Rapamycin in Patients with Prostate Cancer Under Active Surveillance to Prevent Progression
Authors: Kemp Bohan Phillip M. , Chick Robert C. , O'Shea Anne E. , Vreeland Timothy J. , Hickerson Annelies T. , Cindass Jessica L. , Ensley Daniel C. , Hale Diane , Clifton Guy T. , Sohn Vance Y. , Thompson Ian M. , Peoples George E. , Liss Michael A.
Published: April 2023

Supplemental File 2
Supplemental File 1 from Phase I Trial of Encapsulated Rapamycin in Patients with Prostate Cancer Under Active Surveillance to Prevent Progression
Authors: Kemp Bohan Phillip M. , Chick Robert C. , O'Shea Anne E. , Vreeland Timothy J. , Hickerson Annelies T. , Cindass Jessica L. , Ensley Daniel C. , Hale Diane , Clifton Guy T. , Sohn Vance Y. , Thompson Ian M. , Peoples George E. , Liss Michael A.
Published: April 2023

Supplemental File 1
Supplementary Table from Weight Loss and/or Sulindac Mitigate Obesity-associated Transcriptome, Microbiome, and Protumor Effects in a Murine Model of Colon Cancer
Authors: Bowers Laura W. , Glenny Elaine M. , Punjala Arunima , Lanman Nadia A. , Goldbaum Audrey , Himbert Caroline , Montgomery Stephanie A. , Yang Peiying , Roper Jatin , Ulrich Cornelia M. , Dannenberg Andrew J. , Coleman Michael F. , Hursting Stephen D.
Published: April 2023

Supplementary Table from Weight Loss and/or Sulindac Mitigate Obesity-associated Transcriptome, Microbiome, and Protumor Effects in a Murine Model of Colon Cancer
Supplementary Data from Statin Exposure and Pancreatic Cancer Incidence: A Japanese Regional Population-Based Cohort Study, the Shizuoka Study
Authors: Saito Kohei , Sato Yoko , Nakatani Eiji , Kaneda Hideaki , Yamamoto Seiichiro , Miyachi Yoshiki , Itoh Hiroshi
Published: April 2023

Supplementary Figure 1, Supplementary Tables 1-9 and Supplementary Appendix 1
Table S5 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma
Authors: Rettig Eleni M. , Talbot C. Conover , Sausen Mark , Jones Sian , Bishop Justin A. , Wood Laura D. , Tokheim Collin , Niknafs Noushin , Karchin Rachel , Fertig Elana J. , Wheelan Sarah J. , Marchionni Luigi , Considine Michael , Ling Shizhang , Fakhry Carole , Papadopoulos Nickolas , Kinzler Kenneth W. , Vogelstein Bert , Ha Patrick K. , Agrawal Nishant
Published: April 2023

NFIB fusion genes.
Supplement 3 from Novel Models of Genetic Education and Testing for Pancreatic Cancer Interception: Preliminary Results from the GENERATE Study
Authors: Furniss C. Sloane , Yurgelun Matthew B. , Ukaegbu Chinedu , Constantinou Pamela E. , Lafferty Catherine C. , Talcove-Berko Eliana R. , Schwartz Alison N. , Stopfer Jill E. , Underhill-Blazey Meghan , Kenner Barbara , Nelson Scott H. , Okumura Sydney , Law Sherman , Zhou Alicia Y. , Coffin Tara B. , Rodriguez Nicolette J. , Uno Hajime , Ocean Allyson J. , McAllister Florencia , Lowy Andrew M. , Lippman Scott M. , Klein Alison P. , Madlensky Lisa , Petersen Gloria M. , Garber Judy E. , Goggins Michael G. , Maitra Anirban , Syngal Sapna
Published: April 2023

Socioeconomic background questionnaire
Supplementary Tables 3-5 from Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype
Authors: Kanth Priyanka , Bronner Mary P. , Boucher Kenneth M. , Burt Randall W. , Neklason Deborah W. , Hagedorn Curt H. , Delker Don A.
Published: April 2023

Suppl Table 3 - CIMP-H and MLH1 Suppl Table 4 - BRAF co-ocurrence Suppl Table 5 - Sensitivity and specificity with ANXA10 and CLDN1
Supplementary Figure from Variant Identification in BARD1, PRDM9, RCC1, and RECQL in Patients with Ovarian Cancer by Targeted Next-generation Sequencing of DNA Pools
Authors: Suszynska Malwina , Ratajska Magdalena , Galka-Marciniak Paulina , Ryszkowska Aleksandra , Wydra Dariusz , Debniak Jaroslaw , Jasiak Anna , Wasag Bartosz , Cybulski Cezary , Kozlowski Piotr
Published: April 2023

Supplementary Figure from Variant Identification in BARD1, PRDM9, RCC1, and RECQL in Patients with Ovarian Cancer by Targeted Next-generation Sequencing of DNA Pools
Supplementary Tables 2C-E from Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype
Authors: Kanth Priyanka , Bronner Mary P. , Boucher Kenneth M. , Burt Randall W. , Neklason Deborah W. , Hagedorn Curt H. , Delker Don A.
Published: April 2023

Suppl Table 2C - 27 SSA/P genes with high fold change Suppl Table 2D - 28 SSA/P genes by cross validation Suppl Table 2E - Final 51 SSA/P gene signature
Supplementary Table 1 from Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype
Authors: Kanth Priyanka , Bronner Mary P. , Boucher Kenneth M. , Burt Randall W. , Neklason Deborah W. , Hagedorn Curt H. , Delker Don A.
Published: April 2023

Patient Demographics
Cubic spline for the association between OPN levels and HCC from Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population
Authors: Duarte-Salles Talita , Misra Sandeep , Stepien Magdalena , Plymoth Amelie , Muller David , Overvad Kim , Olsen Anja , Tjønneland Anne , Baglietto Laura , Severi Gianluca , Boutron-Ruault Marie-Christine , Turzanski-Fortner Renee , Kaaks Rudolf , Boeing Heiner , Aleksandrova Krasimira , Trichopoulou Antonia , Lagiou Pagona , Bamia Christina , Pala Valeria , Palli Domenico , Mattiello Amalia , Tumino Rosario , Naccarati Alessio , Bueno-de-Mesquita H.B(as). , Peeters Petra H. , Weiderpass Elisabete , Quirós J. Ramón , Agudo Antonio , Sánchez-Cantalejo Emilio , Ardanaz Eva , Gavrila Diana , Dorronsoro Miren , Werner Mårten , Hemmingsson Oskar , Ohlsson Bodil , Sjöberg Klas , Wareham Nicholas J. , Khaw Kay-Tee , Bradbury Kathryn E. , Gunter Marc J. , Cross Amanda J. , Riboli Elio , Jenab Mazda , Hainaut Pierre , Beretta Laura
Published: April 2023

Multivariable adjusted odds ratio (continuous line) and 95% CI (dotted line) are shown for the continuous levels of OPN values associated to HCC. Reference value was set at 47.15 ng/ml (the optimal cut-off point) for all subjects. For better visibility, the levels were truncated at 1 and 99 percentile of distribution.
Supplementary Table 2 from HIST1H2BB and MAGI2 Methylation and Somatic Mutations as Precision Medicine Biomarkers for Diagnosis and Prognosis of High-grade Serous Ovarian Cancer
Authors: Valle Blanca L. , Rodriguez-Torres Sebastian , Kuhn Elisabetta , Díaz-Montes Teresa , Parrilla-Castellar Edgardo , Lawson Fahcina P. , Folawiyo Oluwasina , Ili-Gangas Carmen , Brebi-Mieville Priscilla , Eshleman James R. , Herman James , Shih Ie-Ming , Sidransky David , Guerrero-Preston Rafael
Published: April 2023

Survival alleles at SNV level
Supplementary Data from Celecoxib Colorectal Bioavailability and Chemopreventive Response in Patients with Familial Adenomatous Polyposis
Authors: Yang Peiying , Zuo Xiangsheng , Advani Shailesh , Wei Bo , Malek Jessica , Day Rena Sue , Shureiqi Imad
Published: April 2023

Supplementary Data from Celecoxib Colorectal Bioavailability and Chemopreventive Response in Patients with Familial Adenomatous Polyposis
Supplementary Tables from The Effect of Mouse Strain, Sex, and Carcinogen Dose on Toxicity and the Development of Lung Dysplasia and Squamous Cell Carcinomas in Mice
Authors: Riolobos Laura , Gad Ekram A. , Treuting Piper M. , Timms Andrew E. , Hershberg Elliot A. , Corulli Lauren R. , Rodmaker Erin , Disis Mary L.
Published: April 2023

Supplementary Table S1. Weight changes in different treatment groups for each mouse strain. Supplementary Table S2. Weight change in NTCU treated mice is sex independent. Supplementary Table S3. Survival in NTCU treated mice is sex independent. Supplementary Table S4. Immune phenotype of splenocytes from FVB and NIH Swiss mice treated 4 weeks with 40mM NTCU either subsequent or concomitant to vaccination with IGF1R. Supplementary Table S5. Immune phenotype of splenocytes from NIH Swiss and FVB mice treated with NTCU for 24-32 weeks.
Supplemental Table 2 from Cancer-related Beliefs and Preventive Health Practices among Residents of Rural versus Urban Counties in Alabama
Authors: Aly Salma , Daniel Casey L. , Bae Sejong , Scarinci Isabel C. , Hardy Claudia M. , Fouad Mona N. , Baskin Monica L. , Hoenemeyer Teri , Acemgil Aras , Demark-Wahnefried Wendy
Published: April 2023

Supplemental Table 2
Supplementary Table from Chemoprevention of Azoxymethane-induced Colon Carcinogenesis by Delta-Tocotrienol
Authors: Husain Kazim , Zhang Anying , Shivers Steve , Davis-Yadley Ashley , Coppola Domenico , Yang Chung S. , Malafa Mokenge P.
Published: April 2023

This file contains Supplementary Table 1.
Figure S3 from Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden
Authors: Montrose David C. , Zhou Xi Kathy , McNally Erin M. , Sue Erika , Yantiss Rhonda K. , Gross Steven S. , Leve Nitai D. , Karoly Edward D. , Suen Chen S. , Ling Lilan , Benezra Robert , Pamer Eric G. , Dannenberg Andrew J.
Published: April 2023

Celecoxib treatment reduces proliferation in the base of ileal and colonic crypts from WT mice.
Table S3 from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations
Authors: Chen Kun-Ming , Sun Yuan-Wan , Kawasawa Yuka Imamura , Salzberg Anna C. , Zhu Junjia , Gowda Krishne , Aliaga Cesar , Amin Shantu , Atkins Hannah , El-Bayoumy Karam
Published: April 2023

Histological feature in the oral tissues of mice treated with DBP and DBP + BRB.
Table S1A from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations
Authors: Chen Kun-Ming , Sun Yuan-Wan , Kawasawa Yuka Imamura , Salzberg Anna C. , Zhu Junjia , Gowda Krishne , Aliaga Cesar , Amin Shantu , Atkins Hannah , El-Bayoumy Karam
Published: April 2023

Hypermethylated loci identified in oral tissues of mice treated with DBP and fed control diet or mice treated with DBP and fed 5% BRB diet.
Supplementary Data Legends from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations
Authors: Chen Kun-Ming , Sun Yuan-Wan , Kawasawa Yuka Imamura , Salzberg Anna C. , Zhu Junjia , Gowda Krishne , Aliaga Cesar , Amin Shantu , Atkins Hannah , El-Bayoumy Karam
Published: April 2023

Supplemental Data Legends for Tables and Figures
Figure S2 from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations
Authors: Chen Kun-Ming , Sun Yuan-Wan , Kawasawa Yuka Imamura , Salzberg Anna C. , Zhu Junjia , Gowda Krishne , Aliaga Cesar , Amin Shantu , Atkins Hannah , El-Bayoumy Karam
Published: April 2023

A representative H&E staining showing the histological features identified in the oral tissues of mice. The box indicates the area magnified for the inset. The inset shows epithelial hyperplasia with atypia.
Table S1 from The Acceptability and Preference of Vaginal Self-sampling for Human Papillomavirus (HPV) Testing among a Multi-ethnic Asian Female Population
Authors: Khoo Su Pei , Lim Wen Tzien , Rajasuriar Reena , Nasir Nazrila Hairizan , Gravitt Patti , Woo Yin Ling
Published: April 2023

This supplementary file contains information on the common barriers to Pap test among Malaysian women.
Figure S1 from Black Raspberry Inhibits Oral Tumors in Mice Treated with the Tobacco Smoke Constituent Dibenzo(def,p)chrysene Via Genetic and Epigenetic Alterations
Authors: Chen Kun-Ming , Sun Yuan-Wan , Kawasawa Yuka Imamura , Salzberg Anna C. , Zhu Junjia , Gowda Krishne , Aliaga Cesar , Amin Shantu , Atkins Hannah , El-Bayoumy Karam
Published: April 2023

Analysis of methylation data obtained by ERRBS in oral tissues of mice treated with DBP and fed control diet vs. mice treated with DBP and fed 5% BRB diet. (A) Differential methylation annotation. (B) Unsupervised analysis of DNA methylation using hierarchical clustering (distanceâ€Š=â€Š1-Pearson correlation, Ward's agglomeration method) Cluster: filtered (count >= 10, coverage <= 99.9th percentile), normalized, destranded. (C) Principal component analysis (PCA) of methylated data. (D) Stacking bar plots showing percentage of hyper and hypomethylated differential methylated sites out of all covered CpGs per chromosomes (Chr): filtered, normalized, destranded, q < 0.01, % methylation difference > 25%.
Supplemental Figure 4. Upstream regulator analysis of predicated pathways linked to Fads1 Null/Wt differentially expressed genes. from A New Model to Study the Role of Arachidonic Acid in Colon Cancer Pathophysiology
Authors: Fan Yang-Yi , Callaway Evelyn , M. Monk Jennifer , S. Goldsby Jennifer , Yang Peiying , Vincent Logan , S. Chapkin Robert
Published: April 2023

Data were analyzed using IPA. Selected networks with a Z score < -2.0, and p-value of overlap < 0.001 are reported.
Supplemental Figure 3. AA supplementation normalizes CD3+ T cell numbers in Fads1 mice. from A New Model to Study the Role of Arachidonic Acid in Colon Cancer Pathophysiology
Authors: Fan Yang-Yi , Callaway Evelyn , M. Monk Jennifer , S. Goldsby Jennifer , Yang Peiying , Vincent Logan , S. Chapkin Robert
Published: April 2023

Mononuclear cells were isolated from pooled spleens, mesenteric and inguinal lymph nodes. CD3+ T cell population was further analyzed by flow cytometry. Data are reported as percentage of CD3+ T cells in the mononuclear cells. (mean {plus minus} SE, n=4-6). Bars not sharing the same letter indicate significant differences (P < 0.05).
Supplementary Figure from Effect of Aspirin on Melanoma Incidence in Older Persons: Extended Follow-up of a Large Randomized Double-blind Placebo-controlled Trial
Authors: Yan Mabel K. , Orchard Suzanne G. , Adler Nikki R. , Wolfe Rory , McLean Catriona , Rodriguez Luz María. , Woods Robyn L. , Gibbs Peter , Chan Andrew T. , Haydon Andrew , Mar Victoria J.
Published: April 2023

Supplementary Figure from Effect of Aspirin on Melanoma Incidence in Older Persons: Extended Follow-up of a Large Randomized Double-blind Placebo-controlled Trial
Supplementary Data Table S4 from Genome-Wide Meta-analysis of Gene–Environmental Interaction for Insulin Resistance Phenotypes and Breast Cancer Risk in Postmenopausal Women
Authors: Jung Su Yon , Mancuso Nick , Yu Herbert , Papp Jeanette , Sobel Eric , Zhang Zuo-Feng
Published: April 2023

phenotype4.homair
Supplementary Data Table S2 from Genome-Wide Meta-analysis of Gene–Environmental Interaction for Insulin Resistance Phenotypes and Breast Cancer Risk in Postmenopausal Women
Authors: Jung Su Yon , Mancuso Nick , Yu Herbert , Papp Jeanette , Sobel Eric , Zhang Zuo-Feng
Published: April 2023

phenotype2.glucose
Ratio of creatine/betaine in the liver of mouse DEN-initiated HCC model from Metabolome Analyses Uncovered a Novel Inhibitory Effect of Acyclic Retinoid on Aberrant Lipogenesis in a Mouse Diethylnitrosamine-Induced Hepatic Tumorigenesis Model
Authors: Qin Xian-Yang , Tatsukawa Hideki , Hitomi Kiyotaka , Shirakami Yohei , Ishibashi Naoto , Shimizu Masahito , Moriwaki Hisataka , Kojima Soichi
Published: April 2023

Boxplot of quantitative data displays the full range of variation (from min to max). n.s., not significant.
Supplementary Table 2 from Long-Term Glucocorticoid Use and Cancer Risk: A Population-Based Cohort Study in South Korea
Authors: Oh Tak Kyu , Song In-Ae
Published: April 2023

ICD-10 codes for autoimmune disease
Supplementary Data from Risk of De Novo Hepatocellular Carcinoma Following Use of Direct Acting Antiviral Medications for Treatment of Chronic Hepatitis C
Authors: Antwi Samuel O. , Van Houten Holly K. , Sangaralingham Lindsey R. , Patel Tushar
Published: April 2023

Supplementary Data
Supplementary Table 3 from Cost Effectiveness of Whole Population BRCA Genetic Screening for Cancer Prevention in Israel
Authors: Michaan Nadav , Leshno Moshe , Safra Tamar , Sonnenblick Amir , Laskov Ido , Grisaru Dan
Published: April 2023

Supplementary Table 3 BRCA carriers followup costs
Supplementary Table 2 from Cost Effectiveness of Whole Population BRCA Genetic Screening for Cancer Prevention in Israel
Authors: Michaan Nadav , Leshno Moshe , Safra Tamar , Sonnenblick Amir , Laskov Ido , Grisaru Dan
Published: April 2023

Supplementary Table 2 breast cancer treatment costs
Supplementary Figures and Tables from Inhibition of miR-21 Regulates Mutant KRAS Effector Pathways and Intercepts Pancreatic Ductal Adenocarcinoma Development
Authors: Chu Nina J. , Anders Robert A. , Fertig Elana J. , Cao Minwei , Hopkins Alexander C. , Keenan Bridget P. , Popovic Aleksandra , Armstrong Todd D. , Jaffee Elizabeth M. , Zimmerman Jacquelyn W.
Published: April 2023

Supplementary Figures and Tables
Figure S1 from In Silico Systems Biology Analysis of Variants of Uncertain Significance in Lynch Syndrome Supports the Prioritization of Functional Molecular Validation
Authors: Borras Ester , Chang Kyle , Pande Mala , Cuddy Amanda , Bosch Jennifer L. , Bannon Sarah A. , Mork Maureen E. , Rodriguez-Bigas Miguel A. , Taggart Melissa W. , Lynch Patrick M. , You Y. Nancy , Vilar Eduardo
Published: April 2023

Supplementary Figure S1. Validation of RNA in silico prediction tools using a set of splicing variants already classified as InSIGHT class 1 and 5. A. Proportion of results obtained from different in silico prediction tools at the RNA level stratified per InSIGHT class; B. Results of prediction analysis stratified per InSIGHT class and MMR gene.
Data from Erb-041, an Estrogen Receptor-β Agonist, Inhibits Skin Photocarcinogenesis in SKH-1 Hairless Mice by Downregulating the WNT Signaling Pathway
Authors: Chaudhary Sandeep C. , Singh Tripti , Talwelkar Sarang S. , Srivastava Ritesh K. , Arumugam Aadithya , Weng Zhiping , Elmets Craig A. , Afaq Farrukh , Kopelovich Levy , Athar Mohammad
Published: April 2023

Abstract
Estrogen receptors (ER), including ER-α and ER-β, are known to regulate multiple biologic responses in various cell types. The expression of ER-β is lost in various cancers. ER-β agonists were shown to modulate inflammation, cancer cell proliferation, and differentiation. Here, we investigated the cancer chemopreventive properties of Erb-041, an ER-β agonist, using a model of UVB-induced photocarcinogenesis in SKH-1 mice. Erb-041 significantly reduced UVB-induced carcinogenesis. Tumor numbers and volume were reduced by 60% and 84%, respectively, in the Erb-041–treated group as compared with UVB (alone) control. This inhibition in tumorigenesis was accompanied by the decrease in proliferating cell nuclear antigen (PCNA), cyclin D1, VEGF, and CD31, and an increase in apoptosis. The lost ER-β expression in squamous cell carcinomas (SCC) was significantly recovered by Erb-041 treatment. In addition, the UVB-induced inflammatory responses were remarkably reduced. Myeloperoxidase activity, levels of cytokines (interleukin (IL)-1β, IL-6, and IL-10), and expression of p-ERK (extracellular signal–regulated kinase) 1/2, p-p38, p-IκB, iNOS, COX-2, and nuclear NF-κBp65 were diminished. The number of tumor-associated inflammatory cells (GR-1+/CD11b+ and F4/80+) was also decreased. Tumors excised from Erb-041–treated animal were less invasive and showed reduced epithelial–mesenchymal transition (EMT). The enhanced expression of E-cadherin with the concomitantly reduced expression of N-cadherin, Snail, Slug, and Twist characterized these lesions. The WNT/β-catenin signaling pathway, which underlies pathogenesis of skin cancer, was found to be downregulated by Erb-041 treatment. Similar but not identical changes in proliferation and EMT regulatory proteins were noticed following treatment of tumor cells with a WNT signaling inhibitor XAV939. Our results show that Erb-041 is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. Cancer Prev Res; 7(2); 186–98. ©2013 AACR.
Data from Meat Consumption, Nonsteroidal Anti-Inflammatory Drug Use, and Mortality among Colorectal Cancer Patients in the California Teachers Study
Authors: Zell Jason A. , Ziogas Argyrios , Bernstein Leslie , Clarke Christina A. , Deapen Dennis , Largent Joan A. , Neuhausen Susan L. , Stram Daniel O. , Ursin Giske , Anton-Culver Hoda
Published: April 2023

Abstract
A low-meat diet and regular use of nonsteroidal anti-inflammatory drugs (NSAID) have been associated with decreased mortality among colorectal cancer (CRC) patients. Here, we investigated the association between prediagnosis usual meat consumption and CRC-specific mortality, and whether meat consumption modifies the previously noted association between NSAID use and CRC-specific mortality among women in the California Teachers Study cohort. Women joining the California Teachers Study in 1995-1996 without prior CRC diagnosis, diagnosed with incident CRC during follow-up through December 2007, were eligible for inclusion. Meat intake (frequency and serving size) and NSAID use (aspirin or ibuprofen use) were ascertained via self-administered questionnaires before diagnosis. Vital status and cause of death were determined by linkage with mortality files. Multivariable Cox proportional hazards regression models were used to estimate hazard ratios for death and 95% confidence intervals. Prediagnosis meat consumption was not associated with CRC-specific mortality among 704 CRC patients (and 201 CRC-specific deaths), comparing patients in the lowest consumption tertile (0-5.4 medium-sized servings/wk) to those in the higher consumption tertiles. Regular NSAID use (1-3 times/wk, 4-6 times/wk, daily) versus none was associated with decreased CRC-specific mortality among patients in the lowest meat consumption tertile (hazard ratio, 0.22; 95% CI, 0.06-0.82), but not among patients in the higher meat intake tertiles. The previously observed mortality risk reduction among female CRC patients associated with regular NSAID use was restricted to patients who reported low meat intake before diagnosis. These findings have implications for CRC survivorship and tertiary CRC prevention. Cancer Prev Res; 3(7); 865–75. ©2010 AACR.