bluuebunny/crossref_metadata_2025 huggingface dataset:
Depletion of CD206+ Tumour Macrophages via a Peptide Targeted Star-Shaped Polyglutamate Inhibits Tumourigenesis and Metastatic Dissemination in Mouse Breast Cancer Models
Authors: Lepland Anni , Malfanti Alessio , Haljasorg Uku , Asciutto Eliana , Pickholz Monica , Bringas Mauro , Đorđević Snežana , Salumäe Liis , Peterson Pärt , Teesalu Tambet , Vicent María , Scodeller Pablo
Published: December 2021

Although many studies have explored the depletion of tumour-associated macrophages (TAMs) as a therapeutic strategy for solid tumours, currently available compounds suffer from poor efficacy and dose-limiting side effects. Here, we developed a novel TAM-depleting agent ("OximUNO") that specifically targets CD206+ TAMs and demonstrated efficacy in triple negative breast cancer (TNBC) mouse models. OximUNO comprises a star-shaped polyglutamate (St-PGA) decorated with the CD206-targeting peptide mUNO that carries the chemotherapeutic drug doxorubicin (DOX). In TNBC models, a fluorescently-labelled mUNO-decorated St-PGA homed to CD206+ TAMs within primary lesions and metastases. OximUNO exhibited no acute liver or kidney toxicity in vivo. Treatment with OximUNO reduced the progression of primary tumour lesions and pulmonary metastases, significantly diminished the number of CD206+ TAMs and increased the CD8/FOXP3 expression ratio (demonstrating immunostimulation). Our findings suggest the potential benefit of OximUNO as a TAM-depleting agent for TNBC treatment. Importantly, our studies also represent the first report of a peptide-targeted St-PGA as a targeted therapeutic nanoconjugate.
The Effects of The Royal Jelly On Dry Mouth Sensation With Normal Saliva Function: A Double-Blind, Placebo-Controlled, Cross-Over Trial Clinical Study
Authors: Mochizuki Yumi , Tushima Fumihiko , Kabasawa Yuji , Harada Hiroyuki
Published: December 2021

Background: Because there are no standardized treatment methods for dry mouth sensation with normal salivary function, cases of dry mouth sensation continually suffer. The aim of this clinical study was to evaluate the effects of a royal jelly tablets on dry mouth sensation, in patients with normal salivary function. Methods: This double-blind randomized clinical trial was carried out in the Department of Oral and Maxillofacial Surgery, Tokyo Medical and Dental University Hospital between November, 2019 and April, 2020. This clinical trial was randomized, double-blind, and of a crossover design, with a four-week washout period. Each participant received either 800 mg of royal jelly tablets or placebo, daily for 12 weeks. Results: Differences in VAS scores between royal jelly tablets and placebo were evaluated at 4 and 12 weeks, and were significant. Differences in HADS and GHQ12 scores between those exposed to royal jelly tablets and placebo, at the evaluation period of 12 weeks, were statistically significant. A statistically significant decrease in HADS scores in the royal jelly tablet group, was observed over time. Conclusions: These findings show that daily consumption of royal jelly (800 mg) for 12 weeks was effective in alleviating dry mouth sensation with normal saliva function.Clinical trial registration numbers and the full date of first registration: ClinicalTrials.gov (jRCTs031190067); 02/08/2019
Linking Tree Cover Change to Historical Management Practices in Urban Parks
Authors: Nix Sabine , Roman Lara , Healy Marc , Rogan John , Pearsall Hamil
Published: December 2021

ContextUrban parks provide critical ecological, health, and social benefits, constituting a substantial proportion of urban tree canopy (UTC) within a given city. As cities set ambitious UTC targets, it is critical to understand the social drivers of UTC changes in parks. ObjectivesWe sought to uncover the feedbacks between social processes, including historical events, and park UTC in a post-industrial city that experienced substantial population loss and urban park disinvestment. Methods Our mixed-methods approach involved quantifying spatiotemporal UTC changes and connecting those changes to historical management practices for three parks in Philadelphia, PA (US). We delineated UTC using aerial imagery between 1959 and 2018, and synthesized information from archival records and semi-structured interviews about historical management practices. ResultsWe found substantial UTC gains between 1959 and 1980, due to both: (a) budget cuts, mowing cessation, and associated unintended forest emergence; and (b) purposeful tree planting and reforestation activities. While some UTC gains were purposeful, others were unintentional and reflect successional processes on unmaintained lands. Contrary to literature suggesting that financial investment would lead to UTC gain, we saw declining UTC following an influx of new funding post-2000 due to construction and ecological restoration. ConclusionsWe found differing pathways leading to convergent outcomes of UTC gains. Across the three parks, differing historical processes and management goals for park landscapes had important ramifications for UTC. Our work suggests that landscape management could benefit from an improved understanding of how historical processes impact land cover.
Сollection of representatives of the genus Larix Mill. (Pinaceae) in the Botanical Garden of the Forestry University (St. Petersburg, Russia)
Authors: Шибанов С.А. , Орлова Л.В. , Фирсов Г.А.
Published: December 2021

В Нижнем и Верхнем дендрологических садах Санкт-Петербургского государственного лесотехнического университета в Санкт-Петербурге выращивается 13 видов и 1 гибрид рода Larix Mill., представленных 124 экземплярами, в возрасте от 25 до 200 лет. Все зимостойки, образуют шишки, 3 вида (L. archangelica, L. decidua, L. sibirica) дают самосев. Всего за период интродукции были испытаны 23 таксона рода Larix, наибольшее число видов здесь впервые испытал Э.Л. Вольф. Некоторые виды (L. komarovii, L. maritima) здесь были впервые введены культуру. В коллекции сохранились старовозрастные экземпляры, посаженные еще в XIX в. – 71 шт., самые старые посадки (9 деревьев) датируются 1820 г. (L. archangelica, L. decidua, L. sibirica). Самое высокое дерево относится к L. sibirica: 34,0 м выс., самое толстое по диаметру ствола – L. decidua: 102 см. Исследования подтверждают важность периодических биометрических измерений и непрерывного мониторинга коллекции. Отдельные деревья заслуживают внесения в базу данных по деревьям-чемпионам по их размерам в высоту и диаметру ствола.

There are 13 species and 1 hybrid of genus Larix Mill., represented by 124 trees, in collection of the Upper and the Lower dendrological gardens of Saint-Petersburg State Forest-Technical University, under the age from 25 till 200 years old. All of them are winter hardy and produce cones. Three species (L. archangelica, L. decidua, L. sibirica) give self-sowing. Totally there are 23 taxa which have been tested for the period of introduction. The largest amount of species were tested by E.L. Wolf. Some species (L. komarovii, L. maritima) were introduced here into general cultivation. There are trees of old age planted as early as in the XIX century (71). There are 9 of oldest trees cultivating since 1820 (L. archangelica, L. decidua, L. sibirica). The tallest tree is of L. sibirica: 34,0 m high, the most thick on trunk diameter is the tree of L. decidua: 102 см. The research confirm the importance of periodical biometrical measurements and uninterrupted monitoring of all collection. There are certain trees which deserve to be included into the data base on Champion trees on their sizes.
Exploring the Viability of Online Problem-Based Learning Through the Lens of Students and Teachers
Authors:   Department of Medical Education, University College of Medicine and Dentistry, The University of Lahore, Pakistan, Riaz Amna , Khan Rehan Ahmed ,   Riphah Academy of Research and Education, Riphah International University, Rawalpindi, Pakistan, Arooj Mahwish ,   Department of Medical Education, University College of Medicine and Dentistry, The University of Lahore, Pakistan, Iqbal Muhammad Zafar ,   Department of Medical Education, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
Published: December 2021

This study aimed at exploring the perceptions of students and teachers regarding the viability of the online problem-based learning (PBL) approach. The study also aimed to report the perceived merits and demerits of online PBL and offer suggestions to improve it further. To achieve these objectives, a qualitative exploratory study was conducted at the College of Medicine, The University of Lahore from July 2020 to November 2020. Employing purposive sampling, 12 students and 11 teachers were recruited, with experience in both online and face-to-face PBL. The perceived merits and demerits of online PBL were inquired in focus group discussions. Moreover, suggestions to improve the online PBL environment were elicited from both stakeholders. The data was recorded, and then inductively coded and thematically analysed using Atlis.ti software. Students displayed active participation, improved learning and self-regulation during online PBL. The participants valued online PBL as a resourceful, convenient and flexible learning strategy. Some demerits of online PBL were also reported, including student passivity, low motivation and poor concentration, which were mainly attributed to the lack of physical presence. Suggestions to improve the online PBL environment included virtual use of simulation patients and infographics, faculty development, student orientation and technical support. We conclude that online PBL can be used as an effective strategic alternative to face-to-face modality. However, certain challenges exist in online PBL that can jeopardise students’ learning processes. Efforts need to be made to fully capture the essence of the online PBL environment.
Challenges of e-Mentoring Medical Students During the COVID-19 Pandemic
Authors:   Department of Anatomy, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, Simok Anna Alicia , Mat Pa Mohamad Najib ,   Department of Medical Education, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, Abdul Rahim Ahmad Fuad ,   Department of Medical Education, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, Mohammad Jamilah Al-Muhammady ,   Department of Medical Education, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
Published: December 2021

In the current pandemic scenario, the School of Medical Sciences, Universiti Sains Malaysia had adopted an e-mentoring system to help undergraduate medical students acclimatise to new subjects, improve academic performance and decrease attrition. The authors highlight the challenges of e-mentoring, including aspects of interpersonal dynamics, slow development of relationships in e-mentoring and the requirement of specific skills in technology for useful online mentoring, are the few challenges discussed. Some possible solutions were also shared. This article is beneficial to institutions implementing or planning to implement an e-mentoring system.
Hareketli Grafiklerin Göstergebilimsel Çözümlenmesi; Intention Örneği
Authors: Özkirişçi İbrahim Halil
Published: December 2021

Kavramsal düşüncenin görsel iletişim diline aktarılmasında grafik tasarımı, geçmişten günümüze farklı biçemlerle kendini göstermiştir. Gelişen teknoloji ile değişen iletişim yöntemleri, grafik tasarımın düşünsel algoritması ve araçlarında da kendini göstermiştir. Hareketli Grafikler bu anlamda, günlük yaşantılarımızın neredeyse her anında maruz kaldığımız ve okunması gereken görsel bir dil haline gelmiştir. Göstergebilim ise yaşadığı her dönemde çevre ile anlamlı ilişkiler kurma ihtiyacı hisseden türümüz için bir algoritmalar bütünü görevi görmüştür. Anlamlandırma sürecini etkileyen medyumlar ve bilişsel seviye düşünüldüğünde, göstergebilimsel terminoloji de kendi tanımlarını ve bilgisel alışveriş sürecini yeni iletişim araçlarının karşısında yeniden anlamlandırmak durumunda kalmıştır. Bu çalışmanın amacı, hareketli grafikler dilinin göstergebilimsel anlamda çözümlenmesi ile görsel okuryazarlığın ve görsel farkındalığın hem tasarımcı hem de izleyici açısından artırılmasıdır. Bu bağlamda, Apple şirketinin tasarım manifestosu için yayımladığı hareketli grafik çalışması; Intention örneğinin, göstergebilimsel çözümleme yöntemi ile analizi yapılmıştır. Nitel ve betimsel bir yöntemle ilerleyen araştırmada, temel göstergebilim bileşenleri ile hareketli grafik tasarımı arasındaki ilişki irdelenip örnek çalışma üzerinden yorumlanarak sonuçlandırılmıştır.
Apresentação
Authors: Della Giustina Carlos Christian , Silva Iransé Oliveira , Vital André Vasques
Published: December 2021

Apresentação
La Cuestión de Género y los Derechos Humanos en Venezuela: Políticas Públicas en Control de Natalidad
Authors: Mejías Maria Elena Del Valle , Cabrero Mario Barquero , Vallés Juan Enrique Gonzálvez
Published: December 2021

El presente artículo resume un conjunto de reflexiones en torno a las políticas públicas aplicadas de manera formal e informal en Venezuela en relación al control de la natalidad. Específicamente se desarrollan en este artículo las opciones que tiene la mujer venezolana para evitar un embarazo no deseado, el papel de la educación sexual en la educación venezolana y las alternativas a las que se ve obligada a recurrir en caso de quedar embarazada. El artículo se propone un estudio documental comparativo. Está organizado en las siguientes secciones: el derecho de la mujer en la Historia, en la constitución venezolana, bases legales, papel de la educación sexual en el currículum vigente, opciones a las que puede recurrir la mujer venezolana en caso de experimentar un embarazo no deseado y por último algunas reflexiones y recomendaciones finales. Las legislaciones en la materia son comparadas buscando establecer semejanzas y diferencias.
La Producción Científica de Alto Impacto en Humanidades en Iberoamérica: Un Mapeo Sistemático
Authors: Guillén-Chávez Evelyn-Paola , Núñez-Pacheco Rosa , Barreda-Parra Aymé , Verdugo-Castro Sonia , Sánchez-Gómez Mª Cruz
Published: December 2021

La investigación en Humanidades no parece recibir la misma importancia que sí se otorga a las investigaciones de las áreas de la ciencia y la tecnología. El propósito central de este estudio es caracterizar la producción de artículos científicos sobre Humanidades en los últimos cinco años en Iberoamérica. La metodología empleada corresponde al mapeo sistemático de la producción científica. Asimismo, desde el paradigma cualitativo se han analizado las temáticas que se abordan en los diferentes artículos científicos resultantes del proceso, lo cual no solo permite esclarecer cifras, sino también conocer cuál es la tendencia de los puntos de discusión. Se empleó el software webQDA para el análisis de los datos. Los resultados del análisis del mapeo sistemático muestran que el concepto de humanidades ha sido el más referido seguido de investigación. Los países iberoamericanos que tienen producción de artículos científicos son España, Brasil, Chile y Colombia y el mayor porcentaje de publicación fue el año 2018. En relación al índice de impacto de las revistas existen un mínimo de publicaciones en Q1, Q2, Q3 y Q4. También, las áreas geográficas con artículos citados son España, Brasil, Chile y Colombia. Respecto al sexo se visualiza que existe una producción equitativa en la publicación de artículos de mujeres y hombres.
ENSINO, PESQUISA, EXTENSÃO, INTERDICIPLINARIEDADE E HUMANIZAÇÃO PARA FORMAÇÃO EM SAÚDE
Authors: Jorge Novais Nathalia , Sampaio Juliana , Batista Mélo Cláudia , Silvia Laureano Dalle Piagge Carmem
Published: December 2021

Este artigo tem como intuito apresentar alguns desafios e perspectivas para a formação em saúde a partir de três dimensões: a indissociabilidade ensino-pesquisa-extensão; a interdisciplinaridade como ampliação do olhar sobre o mundo; e as contribuições dos saberes indígenas para a humanização do cuidado. Trata-se de um estudo qualitativo por meio do relato de experiência do projeto Partejar Potiguara e das discussões do curso Humanização em Saúde da Universidade Federal da Paraíba. Essas dimensões inspiram a produção de conhecimentos científicos, repensam uma formação étnico-humanística e socialmente orientada, bem como problematizam o modelo biomédico, que compreendia o corpo como uma máquina e negligenciava os fatores culturais, psicológicos e sociais.
TANDEM: NOVAS FORMAS DE APRENDER E ENSINAR LIBRAS E PORTUGUÊS
Authors: Diogenes Menezes Ronny
Published: December 2021

Com o objetivo de contribuir para a aquisição da Libras e Português por Surdos, esse projeto implantou o Tandem como mediador da aprendizagem para alunos dos cursos de Licenciatura do Ceres/UFRN e comunidade surda de Caicó-RN. O Português, tem se tornado um objeto de difícil compreensão por muitos surdos, no mesmo caminho se encontra a aprendizagem da Libras por pessoas ouvintes, muitos não encontram o necessário para se aprofundar na língua por meio das disciplinas dos cursos superiores. Para resolver esse problema utilizamos o Tandem como uma ferramenta social para a aprendizagem de Libras e português. Com isso, utilizamos interações presenciais na modalidade Tandem como meio para que que surdos e ouvintes possam, colaborativamente, caminhar na aquisição dessas línguas.
EXTENSÃO UNIVERSITÁRIA NO FORMATO REMOTO COMO ESTRATÉGIA FORTALECEDORA DA INICIATIVA HOSPITAL AMIGO DA CRIANÇA:
Authors: Pinheiro de Medeiros Lays , Emanuelle da Silva Matias Thais , Dantas Diniz Damasceno Ana Luisa , Alanna Araújo de Aquino Débora , Marta Fernandes Pereira Dias Hosana , Pedrosa Lima Simone , Mahara Martins Azevedo Castro Gabrielle
Published: December 2021

Objetivou-se relatar a experiência de discentes dos cursos de saúde da Universidade Federal do Rio Grande do Norte (UFRN) e profissionais do Hospital Universitário Ana Bezerra (HUAB) que atuam como colaboradores do projeto de extensão “Proteção, promoção e apoio a amamentação: fortalecendo a Iniciativa Hospital Amigo da Criança do HUAB”, assim como a eficácia do projeto no formato remoto como uma estratégia de promover saúde durante o período de pandemia de COVID-19. O projeto se deu por meio da produção e publicação de materiais nas mídias digitais disponíveis. Dessa forma, concluímos que houve uma boa aceitação por parte do público, interação satisfatória com as temáticas abordadas e a continuidade do fortalecimento da IHAC, que apoia o aleitamento materno em instituições hospitalares.

 

Palavras-chave: extensão; tecnologia digital; aleitamento materno.
Análise bibliométrica do site Circonteúdo: informação como subsídio para a formação circense
Authors: Neumann Susana Elisabeth , Tertulino Ciro Italo
Published: December 2021

As Tecnologias da Informação e Comunicação (TICs) têm renovado os processos de intermediação da informação em diversos contextos da sociedade contemporânea, nos quais a informação é importante tanto no processo contínuo de aprendizagem quanto para a produção de análises bibliométricas. Todavia, não foram encontrados artigos científicos com análises bibliométricas como fonte de informação digital na temática do circo nas bases da ANPAD (2021), CAPES (2021) e SPELL (2021) que possam contribuir para a formação do artista circense. Dessa forma, o presente estudo objetiva analisar, em um corpus de 380 documentos, a produção científica em língua portuguesa disponibilizada no site Circonteúdo, através de uma abordagem quantitativa, baseado na teoria das leis bibliométricas de Lotka, Bradford e Zipf. Os resultados do presente estudo evidenciam o crescimento das produções em um período de 43 anos, as principais fontes de produção/divulgação dessas informações e o papel do site Circonteúdo como mediador no processo de formação continuada do artista circense para além dos ambientes formais de ensino, apresentando-se assim como uma fonte confiável e relevante para os estudos métricos sobre a formação circense.
REDESCRIPTION OF EREMOBELBA GRACILIOR BERLESE, 1908 (ACARI, ORIBATIDA, EREMOBELBIDAE)
Authors: Ermilov Sergey G.
Published: December 2021

The redescription of Eremobelba gracilior Berlese, 1908 (Oribatida, Eremobelbidae) is presented, based on the material colleсted in Washington D. C. and Columbia, Missouri (USA). Main morphological traits of this species are summarized.
REMOCIÓN DE CADMIO Y PLOMO EN UN EFLUENTE MINERO DE TICAPAMPA-RECUAY, ANCASH CON BIOMASA SECA DE Serratia marcescens M8a-2T
Authors: Alegre Quijano Antori , Gutiérrez Moreno Susana M.
Published: December 2021

En el presente trabajo se utilizó biomasa seca de Serratia marcescens M8a-2T con el objetivo de remover cadmio y plomo presentes en una muestra de efluente minero en concentraciones de 496,18 µg/L y 513,55 µg/L respectivamente. La optimización de la remoción de dichos metales se realizó usando la Metodología de Superficie de Respuesta (RSM) y el diseño experimental de Box-Behnken considerando las variables pH (2; 3 y 4), concentración de biomasa (1; 2 y 3 mg/mL) y tiempo de contacto (15; 30 y 45 minutos). El porcentaje máximo de remoción de cadmio que se obtuvo fue de 97,11% a pH 4, con 2 mg/mL de biomasa durante 45 minutos. Mientras que el porcentaje máximo de remoción de plomo fue de 98,63% a pH 4, con 1 mg/mL de biomasa durante 30 minutos de contacto. Los altos niveles de significancia (p<0.05) de los modelos de regresión y ANOVA obtenidos indican al pH como la variable de mayor influencia. La Metodología de Superficie de Respuesta demostró ser de mucha utilidad para optimizar procesos de biorremediación.
EFECTO DEL CAFÉ FERMENTADO CON BIOPRODUCTO SOBRE LA GERMINACIÓN DE SEMILLAS Y EL DESARROLLO DE POSTURAS
Authors: Ferrás Negrín Yusdel , Bustamante González Carlos , Díaz Solares Maykelis , Sánchez Esmori Ciro
Published: December 2021

El IHPLUS es un bioproducto a base de microorganismos eficientes que constituyen una opción para el desarrollo de los cultivos. La investigación tuvo como objetivo evaluar el efecto del café fermentado con IHPLUS sobre la germinación de semillas y el desarrollo de posturas. Posterior al despulpe del café la fermentación se realizó en cuatro concentraciones con IHPLUS (5%, 10%, 15% y 20%), y un testigo con agua sola. Se evaluó el por ciento de germinación, la altura, el largo de la raíz y la masa seca de las plántulas cuando tuvieron las hojas cotiledonares, y la altura, el diámetro del tallo, el área foliar y la masa seca de las posturas al finalizar su aviveramiento. Al fermentar las semillas en un medio con mayor concentración de bioproducto se aumentó la germinación, los tratamientos 15% y 20% incrementaron este indicador en un 13,4 y 16,1% respectivamente en comparación al testigo. En germinadores las plántulas tuvieron mejores características morfo-fisiológicas con las concentraciones del bioproducto, sobre todo con el 15%. En las posturas la concentración del 15% incrementó en un 17,9; 26,8; 50 y 38,6% la altura, el diámetro del tallo, la masa seca y el área foliar respectivamente en comparación al testigo. El IHPLUS en la fermentación de las semillas de café mejoró significativamente el por ciento de germinación, los indicadores de calidad de las plántulas en los germinadores y de las posturas al concluir su aviveramiento. La concentración del 15% fue la variante más integral y recomendable a utilizar.
EFECTO DE LA SUPLEMENTACIÓN ENZIMÁTICA EN PARÁMETROS PRODUCTIVOS DE CUYES (LÍNEA SINTÉTICA P 0.625)
Authors: Bernaola Rodriguez Ferggie , Chauca Francia Lilia , Orrego Vásquez Fernando
Published: December 2021

The aim of this study was to evaluate the effect of the supplementation of an enzymatic complex in integral diets for guinea pigs in the growing phase on productive performance. In total, 54 male guinea pigs (Synthetic line P 0.625) were used and submitted to a diet free of the enzyme complex (T1), and two experimental ones, one with 0.1% (T2) and the other with 0.2% (T3) of enzyme complex evaluated between two weeks of age (weaning) and after rearing (nine weeks old). It was statically evaluated and there were found no significant difference between treatments in relation to final body weight, weight gain, feed intake and feed conversion; and it was reported the weekly average of percentage of dairy dry matter intake by body weight.
Good Uptake of the COVID-19 Vaccine among Patients with Rheumatic
Diseases in the United Arab Emirates (UAE)
Authors: Elsheikh Azza A.M. , Badsha Humeira
Published: December 2021

Background:

Many patients with rheumatic diseases are immunosuppressed and
take forms of immunomodulator medication. Hence, these patients might be at a heightened risk of Covid-19 and have special concerns in regard to vaccines, such as safety and efficacy. Vaccines have been available for the population of UAE as of January 2021, these being Pfizer (the United States and Europe), Sinopharm (China), and AstraZeneca (United Kingdom). The aim of our paper was to examine the rate of vaccine uptake among our patients with rheumatic conditions in the United Arab Emirates.

Methods:

A questionnaire was distributed among patients with rheumatic diseases attending a rheumatology specialised clinic in the United Arab Emirates. We collected data on 149 consecutive patients who were seen during a one-month period from 10/06/2021 to 10/07/2021 in Dubai.

Results:

The mean age of the patients was 45.9 +/- 41.3. The majority of the patients had underlying rheumatic diseases (86.9%), the rest having conditions such as soft tissue pain or to rule out rheumatic conditions. 48.5% were taking immunomodulators. 41.7% of respondents had other chronic diseases. It was also found that 18.9% had Covid-19 previously, all of whom recovered, with the average duration of the illness being 11 days.
99.1% of individuals reported that receiving the Covid-19 vaccine was extremely important, and 95.0% had already received the vaccination. Their reasoning for receiving the vaccination varied from medical advice (17.5%), general worry about infection/ reinfection of Covid-19 (65.3%), in order to travel (8.4%), employee requirement (5.6%), and other reasons (3.2%). Specifically, 48.3% chose the Pfizer vaccine, 39.8% had Sinopharm, and 11.9% had AstraZeneca. These decisions on which vaccine to choose were influenced by the availability of the vaccine (35.1%), medical advice (16.9%), effectiveness (15.5%), safety and side effect profile (18.2%), age restrictions (2.7%), experience/ advice from friends and family (8.1%) and other reasons (3.4%).

Conclusion:

Overall, an overwhelming majority of our patients (95.0%) with rheumatic
diseases in the specialised muscular-skeletal clinic in the UAE have received the Covid-19 vaccine. This reflects good public health service messaging and concentrated efforts from the medical community, UAE government, and the patient’s rheumatologists.
EBV Reactivation in A Case of DRESS Syndrome Associated with Lamotrigine: A Case Report
Authors: Kiblawi Mahmoud Ahmed , El Saleh Mohamad , El Ghul Ashraf
Published: December 2021

Background:

Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) is a rare, T-cell mediated hypersensitivity reaction that develops secondary to a drug reaction. Several drugs have been associated with DRESS syndrome, most commonly carbamazepine. The mechanism is not clearly understood. It is a life-threatening condition that can present with skin rash, hematologic abnormalities, lymphadenopathy, and organ failure.

Case Presentation:

The authors report a case of 43-year-old gentleman who developed DRESS syndrome secondary to lamotrigine and was found to have EBV reactivation. Patient was managed with supportive care; topical steroids and the culprit drug were discontinued. He had full recovery almost 2 weeks following treatment. DRESS syndrome can occur 2 weeks following exposure to an offending drug in susceptible individuals.

Conclusion:

Lamotrigine and EBV reactivation are not frequently reported in patients with DRESS syndrome. Therefore, physicians should be vigilant about this rare drug related hypersensitivity reaction in order to prevent life threatening complications.
3-D Printing in Orthopaedic Surgery: Book Review
Authors: Hettiarachchige Diluksha Prasad Jayawardana
Published: December 2021

This is a book review on 3-D printing in orthopedic surgery which is a novel technique on patient care.
A Practical Synthesis of Macrocyclic Schiff Base Bearing Hydroxyethyl
Pendants Utilizing Solubility Discrepancies
Authors: Li Runlai , Li Shu’an , Xia Tian , Ji Chunwei , Gu Na , Li Linzhe , Zhang Zhenming
Published: December 2021

Six macrocyclic Schiff bases bearing hydroxyethyl pendants have been synthesized in high
yields via [2 + 2] condensation between the rigid dialdehydes and 2-[bis(2-aminoethyl)amino]ethanol
or 1-[bis(2-aminoethyl)amino]-2-propanol at 0oC for 12 hours in the CH3CN/H2O mixture. Solubility
discrepancies between macrocyclic products and raw materials in selected solvents enable a facile separation
and high yields, avoiding any intractable chromatographic purification. This straightforward
synthetic protocol provides a relatively facile resolution with potential widespread applications for the
synthesis of Schiff bases.
Environmental Factors as Diabetic Mediators: A Mechanistic Approach
Authors: Firdous Parveena , Nissar Kamran , Bashir Humayra , Hussain Qazi A. , Masoodi Shariq Rashid , Ganai Bashir Ahmad
Published: December 2021

Despite substantial investment in research and treatment options, diabetes mellitus remains
a pressing public health concern with potential epidemic proportions globally. There are reports
that by the end of 2040, 642 million people will be suffering from diabetes. Also, according
to an estimation, 1.6 million deaths were caused directly by diabetes in 2016. Diabetes is a
metabolic disorder characterized by impaired glucose regulation in the body due to the destruction
of pancreatic β-cells or insulin resistance. Genetic propensity, unhealthy and imbalanced diet, obesity
and increasing urbanization are the common risk factors for diabetes. Besides this, it has been reported
that environmental pollutants like organic pesticides, heavy metals, and air pollutants act as
strong predisposing factors for diabetes owing to their highly bio-accumulative nature. These pollutants
disturb glucose homeostasis either by up-regulating or down-regulating the expression of diabetic
marker genes like insulin (INS) and glucokinase (GCK). Unfortunately, the molecular mechanism
of the role of pollutants in causing diabetes is not very clear. This mechanistic review provides
evidence of different environmental determinants, including persistent organic pollutants
(POPs), air pollutants, toxic metals, etc., in inducing diabetes and proposes a framework for the possible
mechanisms involved. It also illuminates the current status and future challenges, which will
not only broaden our understanding but can also be a reasonable platform for further investigation.
Pharmacokinetics Study of Rabdosia rubescens Drop Pills Based on
UPLC-MS/MS
Authors: Li Wei , Yu De-hong , Wei Xi-yu , Zhang Zhen-zhen , Xie Tao , Xie Yue-Sheng , Sun Yue , Yang Ting , Xu Wen-wu , Liu Hou-ru
Published: December 2021

Background:

Rabdosia rubescens drop pills have the effects of clearing away heat and
toxin, detumescence, relieving pain.

Objective:

A simple and sensitive method for simultaneous determination of oridonin, ponicidin,
and rosmarinic acid in rat plasma was developed based on ultra performance liquid chromatography-
tandem mass spectrometry (UPLC-MS/MS).

Methods:

Chromatographic separation was performed on a Waters ACQUITY UPLC BEH C18
column (2.1 × 100 mm, 1.7 μm) with a mobile phase consisting of water containing 0.2% formic
acid (mobile phase A) and methanol (mobile phase B) at a flow rate of 0.3 mL/min over a total
run time of 3.8 min. All analytes were measured with optimized multiple reaction monitoring
(MRM) in positive and negative ion ESI mode.

Results:

The transitions of oridonin, ponicidin, rosmarinic acid, diphenhydramine, and chloramphenicol
were 365.3→347.3, 363.3→345.2, 359.0→160.9, 256.0→167.2, and 321.1→151.9, respectively.
The linear ranges were 1-256 ng/mL for ponicidin and rosmarinic acid and 2-512
ng/mL for oridonin. The validated method was stable and reliable. There was no significant difference
in the half-life (t1/2) of the three analytes at three doses. The area under the curve (AUC0-t)
and peak concentration (Cmax) of the three analytes decreased linearly in each dose range, and the
linear correlation R2 of each analyte under the three doses was greater than 0.95.

Conclusion:

This method was successfully applied to pharmacokinetic studies of oridonin, ponicidin,
and rosmarinic acid in rat plasma after intragastric administration of Rabdosia rubescens drop pills.
Application of Epoxy Resin for Improvement of the Banana Stem- Acoustic Panel
Authors: Riduan Mohd Azril , Jalil Mohd Jumain , Azmi Intan Suhada , Habulat Afifudin , Raofuddin Danial Nuruddin Azlan , Habri Hamzah Hafizuddin , Azmi Mohamad Heiry Mohd
Published: December 2021

Background:

Greener epoxidation by using vegetable oil to create an eco-friendly epoxide is being studied because it is a more cost-effective and environmentally friendly commodity that is safer than non-renewable materials. The aim of this research is to come up with low-cost solutions for banana trunk acoustic panels with kinetic modelling of epoxy-based palm oil.

Method:

In this study, the epoxidation of palm oleic acid was carried out by in situ performic acid to produce epoxidized palm oleic acid.

Results:

Banana trunk acoustic panel was successfully innovated based on the performance when the epoxy was applied. Lastly, a mathematical model was developed by using the numerical integration of the 4th order Runge-Kutta method, and the results showed that there is a good agreement between the simulation and experimental data, which validates the kinetic model.

Conclusion:

Overall, the peracid mechanism was effective in producing a high yield of epoxy from palm oleic acid that is useful for the improvement of acoustic panels based on the banana trunk.
Effect of Vitamin C Supplements on Respiratory Tract Infections: A Systematic
Review and Meta-Analysis
Authors: Keya Tahmina Afrose , Leela Anthony , Fernandez Kevin , Habib Nasrin , Rashid Mumunur
Published: December 2021

Background:

Respiratory tract infections are a primary cause of illness and mortality over the world.

Objective:

This study was aimed to investigate the effectiveness of vitamin C supplementation in preventing and treating respiratory tract infections.

Methods:

We used the Cochrane, PubMed, and MEDLINE Ovid databases to conduct our search. The inclusion criteria were placebo-controlled trials. Random effects meta-analyses were performed to measure the pooled effects of vitamin C supplementation on the incidence, severity, and duration of respiratory illness.

Results:

found ten studies that met our inclusion criteria out of a total of 2758.The pooled risk ratio (RR) of developing respiratory illness when taking vitamin C regularly across the study period was 0⸳94 (with a 95% confidence interval of 0⸳87 to 1⸳01) which found that supplementing with vitamin C lowers the occurrence of illness. This effect, however, was statistically insignificant (P= 0⸳09). This study showed that vitamin C supplementation had no consistent effect on the severity of respiratory illness (SMD 0⸳14, 95% CI -0⸳02 to 0⸳30: I2 = 22%, P=0⸳09). However, our study revealed that vitamin C group had a considerably shorter duration of respiratory infection (SMD -0⸳36, 95% CI -0⸳62 to -0⸳09, P = 0⸳01).

Conclusion:

Benefits of normal vitamin C supplementation for reducing the duration of respiratory tract illness were supported by our meta-analysis findings. Since few trials have examined the effects of therapeutic supplementation, further research is needed in this area.
Semantic study of the use of association, ambiguity, and lexical meanings, daily news headlines of Sinar Indonesia Baru Medan
Authors: Salliyanti Salliyanti , Sibarani Robert , Susilo Hariadi , Harahap Nurhayati
Published: December 2021

This research was field research taken from the Daily News Sinar Indonesia Baru, Medan. The problems to be discussed were association, ambiguity, and lexical meaning. The purpose of this study was to explore or find out the meanings contained in the Daily News headlines in the Sinar Indonesia Baru Medan. To analyze the meaning of the Daily News headlines of the Sinar Indonesia Baru, a structural-semantic theory was used which referred to Abdul Chaer's view. The method used in data collection was the listening method by listening to the collection of existing materials on the daily news headlines of the Medan Sinar Indonesia Baru, then proceeding with the note-taking technique. After that, they were grouped based on the uses of association, ambiguity, and lexical meanings found in the headlines. The equivalent method was a method whose determination tool was outside and did not become part of the language in question. In this case, the basic technique used was the determining element sorting technique. As a continuation, a qualitative description method was used. This means that this qualitative method as a whole makes use of interpretive ways of presenting in the form of a description.
OPTIMIZATION OF DISCHARGE PLANNING FOR COVID-19 PATIENTS THROUGH INTEGRATED EDUCATION SYSTEM COVID NURSE ASSISTANT (CNA) TO PREVENT TRANSMISSION AND IMPROVING PATIENT SELF-CARE ABILITY IN RSSA
Authors:   Clinical Nursing Program, Faculty of Medicine, Universitas Brawijaya, Ningrum Evi Harwiati , Noviyanti Linda Wieke ,   Undergraduated Nursing Program, Faculty of Medicine, Universitas Brawijaya, Rahmawati Ike Nesdia ,   Undergraduated Nursing Program, Faculty of Medicine, Universitas Brawijaya, Kartika Annisa Wuri ,   Undergraduated Nursing Program, Faculty of Medicine, Universitas Brawijaya, Wibisono Ahmad Hasyim ,   Clinical Nursing Program, Faculty of Medicine, Universitas Brawijaya, Ahsan Ahsan ,   Postgraduated Nursing Program, Faculty of Medicine, Universitas Brawijaya, Putra Kuswantoro Rusca ,   Postgraduated Nursing Program, Faculty of Medicine, Universitas Brawijaya
Published: December 2021

The high number of COVID-19 cases was not balanced by the number of nurses assigned to the Covid isolation room with limited PPE availability. This causes many of the duties of nurses, especially health education, could not be performed completely. Thus, it is necessary to renew the Discharge Planning procedure for Covid 19 patients according to the characteristics of Covid-19 transmission. The purpose of this community service is to increase the effectiveness of the discharge planning for the COVID-19 patients to improve self-care and prevent infection transmission at home. This community service activity consists of 4 (four) stages, namely: 1) Preparation stage for coordination with the hospital; 2) Application development phase, consisting of application design, collection of educational media; 3) Implementation, launching and socialization of applications in the hospital environment; 4) Evaluation and monitoring stage. The results of the evaluation showed that as many as 58.7% of patients had used the CNA. About 62.7% patients experience an increase of their knowledge after accessing the CNA. There were 61.6% patients stated that the CNA had increased their knowledge on home care procedure post-Covid treatment. There are 62.3% of patients feel that the CNA supports patient care at home. The benefits of the CNA were expressed by 82 patients (87.2%) with increased self-care and as many as 76 patients (80.9%) stated that the CNA educational media was more attractive and easy to understand. The conclusion of this activity is that the CNA application can be implemented as a medium of health education for patients and families to improve their ability to take care of themselves.
INCREASING COMMUNITY PARTICIPATION IN MAINTAINING CLEANLINESS AND HEALTH TO REALIZE COMFORTABLE TOURISM VILLAGE IN THE VILLAGE OF RINDU HATI
Authors:   Nursing Vocational Program, Faculty of Math and Science, Universitas Bengkulu, Delfina Rina , Sardaniah Sardaniah ,   Nursing Vocational Program, Faculty of Math and Science, Universitas Bengkulu
Published: December 2021

A clean and healthy tourist village is the main attraction for visitors because the beautiful and clean environment makes visitors feel comfortable. Based on the results of the FGD conducted by the University of Bengkulu LPPM in the village of Rindu Hati, several problems were found, such as the cleanliness of the village, the absence of a garbage disposal site. This of course can cause various problems for visitors and the community, one of which can affect public health and the environment. Efforts that can be made are the Guidance of Clean and Healthy Life Behavior (PHBS). The purpose of this community service activity is to provide education to the Rindu Hati village community so that they can maintain environmental cleanliness and health through the proper and correct application of PHBS, increase community knowledge and skills in managing household waste and environmental waste, and improve community skills in disease management. environmental impacts and independently in preventing and overcoming the health problems it faces. The methods used are: health education about waste management, training to utilize waste. The participants who took part in this activity were 50 people consisting of environmental groups, PKK cadres, health cadres, village officials, and housewives. The results of this community service activity show an increase in community participation in maintaining environmental cleanliness and health, this can be seen from the community's ability to implement PHBS and utilize waste that has economic value.
Cissus quadrangularis Aqueous Extract Attenuates Angiotensin II-Induced Hypertension In Urethane-Anesthetized Rats
Authors: Ahmed Faiyaz
Published: December 2021

Hypertension is a major cardiovascular problem resulting in significant mortality. Cissus quadrangularis having several pharmacological effects has not been evaluated for its ability to modulate blood pressure. Thus, the ability of C. quadrangularis aqueous extract (CQE) to modulate blood pressure was evaluated in normotensive and angiotensin II-induced hypertensive rats under urethane anesthesia. The animals were divided into four groups namely, control (saline injection), CQE (extract alone, 10 mg/kg), Ang II (Ang II alone, 0.5 µg/kg) and Ang II + CQE (Ang II + extract). All treatments were delivered by intravenous route and in Ang II + CQE group, Ang II was injected 30 min after injection of the extract. Hemodynamic parameters, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MABP), and heart rate (HR) were recorded by the BIOPAC system after the cannulation of the carotid artery and jugular vein. The results indicated that CQE lowered SBP, DBP, MABP and heart rate to varying degrees in normotensive rats compared to control groups. In case of angiotensin II-induced hypertension, CQE administration resulted in substantial decrease in SBP, DBP, and MABP which were raised by Ang II. CQE reduced SBP, DBP, and MABP by 12, 59, and 11%, respectively. It is worth noting that, while SBP was not brought down to baseline levels by CQE, DBP was, suggesting significant hypotensive/antihypertensive activity of CQE. Further research is required to determine the molecular mechanism of C. quadrangularis extract’s hypotensive/antihypertensive action and to conduct clinical trials to establish its optimal use as an antihypertensive therapeutic.
Screening and Evaluation of a Potential Bacteriocin Producing Lactobacillus in Milk and Dairy Products Collected from Puducherry
Authors: Punithavalli T
Published: December 2021

In an array of identifying safe antimicrobial compounds, bacteriocin producing Lactobacillus strain have been investigated in this study from the daily consuming food resources of humans. Till now, the best studied bacteriocins are nisin A produced by Lactobacillus lactis and pedocin PA-1 synthesized by Pediococcus acidilactici which have been accredited as a preservative in the food industries by the World Health Organization (WHO). For this study, four different milk and dairy products viz., curd, cheese, yoghurt and butter were collected from the local markets of Karaikal region, Puducherry, India and were used for the isolation of Lactobacillus species using MRS agar. Totally, five morphologically distinct strains were collected and were initially named as MPD 1 to MPD 5. During the screening process of bacteriocin production, the strain MPD 5 showed maximum antimicrobial activity against Vibrio cholerae MTCC 3906 with 900AU/ml. This strain was molecular identified as Lactiplantibacillus plantarum MDP 5 based on 16S rRNA partial sequence method. This 16S rRNA partial sequence was submitted to the NCBI nucleotide GenBank and provided with the accession number, MW301154.1. Further, this strain revealed an enhanced production of bacteriocin using the standardized physicochemical factors such as pH 7, 35°C, 2% fructose and 1% peptone. Furthermore, these optimal conditions revealed more than 2-fold increase in the bacteriocin production. All the above information suggesting the possibilities of bacteriocin for the bioindustrial production using the L. plantarum MDP 5 of this study and its future prospects for the investigation of biocidal activities against many highly infectious pathogens of human and veterinary.
Formulation and Quality Evaluation of Foxtail Millet and Semolina Incorporated Ready-To-Cook Upma Mix
Authors: Thara D. Karuna
Published: December 2021

Traditional cuisine has risen to the top of the consumer’s list of preferences. Many traditional cereal-based dishes have been processed, and instant mixes such as instant upma, idli, and dosa have been made. Comfort foods are foods that require little or no processing or cooking before consumption, making them more convenient for the user. Ready to Cook (RTC) and instant foods have grown highly popular as a result of increased urbanization and industrialization, owing to today’s lifestyle and the need for quick-to-serve cuisine.The study’s goal is to develop an RTC upma mix and evaluate its physicochemical, texture, sensory, and in vitro glycemic index. The millet was collected and pre-processing was done to develop the ready-to-cook mixes. The levels of millet incorporation ratio were 60% (V1), 70% (V2), and 80% (V3) levels. Standard procedures were used to determine the physicochemical, textural, sensory, and in vitro glycemic index. The nutritional composition of V3 was found to be high, with moisture, carbohydrate, protein, fat, fibre, soluble fibre, and insoluble fibre content of 6.4 percent, 73.6g, 8.5g, 6.2g, 6.6g, 2.4g, and 0.56g, respectively.The textural profile showed a significant difference (p<0.05) between variations in comparison with the standard. Results on sensory evaluation showed that 70% foxtail millet upma mix shows high acceptable than other. The mean in vitro glycemic index of the control upma mix was 68.7 ± 0.12, while the mean estimated glycemic index value of V1, V2, and V3 was50.5 ± 0.5, 49.8 ± 0.4, and 49.2± 0.6 respectively. Thus, the result evident that all the developed RTC upma mixes exhibited a low glycemic index and were useful for Diabetic subjects and easy to carry as a journey food.