bluuebunny/crossref_metadata_2025 huggingface dataset:
Prebiotics: Categories, Applications, and Insights on the Potential of Herbal Sources as Prebiotics
Authors: Bhagwat Prateeksha , Soni Hemant , tandon Smriti , Singh Gagandeep , Kumar Lale Sanjeev , Kumar Vijay , Narasimhaji Ch. V. , Mathapati Shiddamallayya , Srikanth Narayanam , Acharya Rabinarayan
Published: February 2025

The definition and comprehension of prebiotics have undergone a substantial transformation
over the years, culminating in a consensus in 2016 among an expert panel from the International
Scientist Association for Probiotics and Prebiotics (ISAPP). This revision suggests that prebiotics
are substances that promote the growth of probiotics, thereby benefitting the health of the host.
These substances are no longer restricted to dietary carbohydrates and have expanded to include
bioactive compounds such as polyphenols. The objective of this review is to offer a thorough examination
of carbohydrate-based prebiotics (e.g., FOS, GOS, Inulin), their natural modulation, herbal
interventions, microbial-based substances, and their influence on gut health. Additionally, it will
investigate their association with the Indian traditional medicinal system. A review was conducted
to identify and analyze studies related to prebiotics, including their categories, commercial availability,
and applications. The investigation was expanded to encompass the interactions between the
intestinal microbiome, diet, epigenetics, and the mechanism of action of prebiotics. The relationship
between prebiotics and the Indian traditional medicinal system, emergent dietary inventions, and
microbial products such as synbiotics, postbiotics, and para-probiotics that have demonstrated potential
in gut health management with minimal side effects were all given special attention. The
review emphasizes novel discoveries, including the integration of a variety of dietary interventions
and microbial products into digestive health management, as well as the role of bioactive compounds
(e.g., polyphenols) as potential prebiotics. It also demonstrates the substantial interactions
between the intestinal microbiome, diet, and epigenetics. Additionally, the review emphasizes the
potential synergistic benefits and compatibility of integrating contemporary prebiotic research with
practices from the Ayurvedic medicinal system. The increased understanding of prebiotics, which
extends beyond dietary carbohydrates to encompass a variety of bioactive compounds, creates new
opportunities for research and implementation in the management of integrative gut health. This
review has identified herbal interventions and microbial products as promising frontiers for future
research. The integration of these discoveries into therapeutic interventions and consumer products
has the potential to significantly increase health outcomes with minimal side effects, thereby representing
a significant advancement in the field of gut health research.
Clinical Insights into Protein-based Therapies for Precision Targeting of Psoriasis
Authors: Yadav Krishna , Vijayalakshmi R. , Sahu Kantrol Kumar , . Sucheta , Nagori Kushagra , Singh Deependra , Singh Manju Rawat , Pradhan Madhulika
Published: February 2025

Psoriasis (PsR), a chronic autoimmune disorder, affects millions of individuals globally
and has a substantial impact on their quality of life. This complex condition involves intricate
molecular networks and signaling pathways, making the development of effective treatments
a significant challenge. Moreover, to advance treatment options, precise targeting of cells
through the identification of protein biomarkers in PsR has emerged as a promising field of research
for both fundamental and clinical scientists. These protein components provide valuable
insights into the underlying mechanisms of the disease and can serve as indicators of treatment
response. Furthermore, by identifying specific biocomponents, researchers can develop targeted
therapeutics that address the molecular abnormalities driving PsR. The use of biologics as potential
targets for improving treatment efficacy is a significant focus in PsR research. Biologics,
which include monoclonal antibodies and fusion proteins, specifically target key molecules involved
in the immune response, such as tumor necrosis factor-alpha (TNF-α) and interleukins
(IL). These targeted therapies have demonstrated substantial efficacy in managing PsR by modulating
the immune system and reducing inflammation. Recent advancements in moleculartargeted
therapies utilizing biologics or small-molecule inhibitors have contributed to improving
patient outcomes. This review aims to summarize the recent discoveries and insights regarding
biocomponents and their importance in treating PsR, encompassing both its inflammatory and
dermatological aspects. Furthermore, the review discusses the commercial outcomes of ongoing
clinical trials for various biological-based therapeutic modalities for PsR, providing valuable
insights into the evolving landscape of PsR therapeutics. These developments indicate the growing
interest and investment in improving treatment options for individuals living with PsR.
Ambulatory Uniportal Interlaminar Endoscopic Approach for Symptomatic Adjacent Segment Disease after Lumbar Fusion in Aged Patients
Authors: Coronado Pantoja David Alejandro , Prada Ramírez Nicolas , Muñoz Suárez Diego Roberto , Jaimes Duran Carlos Andrés , Ustate Valera Andrea Yaneth , Ramírez León Jorge Felipe , Rugeles Ortiz Jose Gabriel , Ramirez Martínez Carolina , Alonso Cuéllar Gabriel Oswaldo
Published: February 2025

Background:

There is no consensus on treating symptomatic adjacent segment disease
(ASD). The best choice depends on several factors. Spinal fusion is associated with complications
that may be more relevant in adult patients. The study aimed to report the feasibility and
clinical results obtained in patients over 60 years of age with ASD treated with a uniportal interlaminar
endoscopic approach.

Materials and Methods:

We retrospectively reviewed patients> 60 years old admitted with
radicular symptoms secondary to ASD history between May 2020 and January 2023 who underwent
endoscopic surgery using a uniportal interlaminar approach. We collected information
on patient-reported outcome measures (PROMs), including pre-and postoperative visual analog
scale index (VAS), Oswestry ODI criteria, and patient satisfaction score using the MacNab criteria.

Results:

Eight patients, five women and three men, with an average age of 72.8 ± 7.89 years,
were included in the study. The average follow-up time was 23.0 ± 16.7 months. The difference
between the preoperative and postoperative VAS and ODI was statistically significant. Satisfaction
with the procedure was above 80%, and the results were excellent. There were no intraoperative
complications; only one case had to be reoperated with a conventional technique. No patient
had a hospital stay.

Conclusion:

Ambulatory uniportal interlaminar endoscopic surgery is a technique that may become
an alternative for the treatment of symptomatic ASD in patients over 65 years of age.
Comparison of Learning Outcomes Among Medical Students in Thailand to Determine the Right Time to Teach Forensic Medicine: Retrospective Study
Authors: Chudoung Ubon , Saengon Wilaipon , Peonim Vichan , Worasuwannarak Wisarn
Published: February 2025

Background

Forensic medicine requires background medical knowledge and the ability to apply it to legal cases. Medical students have different levels of medical knowledge and are therefore likely to perform differently when learning forensic medicine. However, different medical curricula in Thailand deliver forensic medicine courses at different stages of medical study; most curricula deliver these courses in the clinical years, while others offer them in the preclinical years. This raises questions about the differences in learning effectiveness.

Objective

We aimed to compare the learning outcomes of medical students in curricula that either teach forensic medicine at the clinical level or teach it at the preclinical level.

Methods

This was a 5-year retrospective study that compared multiple-choice question (MCQ) scores in a forensic medicine course for fifth- and third-year medical students. The fifth-year students’ program was different from that of the third-year students, but both programs were offered by Mahidol University. The students were taught forensic medicine by the same instructors, used similar content, and were evaluated via examinations of similar difficulty. Of the 1063 medical students included in this study, 782 were fifth-year clinical students, and 281 were third-year preclinical students.

Results

The average scores of the fifth- and third-year medical students were 76.09% (SD 6.75%) and 62.94% (SD 8.33%), respectively. The difference was statistically significant (Kruskal-Wallis test: P<.001). Additionally, the average score of fifth-year medical students was significantly higher than that of third-year students in every academic year (all P values were <.001).

Conclusions

Teaching forensic medicine during the preclinical years may be too early, and preclinical students may not understand the clinical content sufficiently. Attention should be paid to ensuring that students have the adequate clinical background before teaching subjects that require clinical applications, especially in forensic medicine.
Challenges of Cross-Sectoral Video Consultation in Cancer Care on Patients’ Perceived Coordination: Randomized Controlled Trial
Authors: Baygi Fereshteh , Bitz Trabjerg Theis , Jensen Lars Henrik , Munch Storsveen Maria , Wehberg Sonja , Sisler Jeffrey James , Søndergaard Jens , Gilså Hansen Dorte
Published: February 2025

Background

Patients with cancer need coordinated care for both treatment and concurrent health conditions. This requires collaboration among specialists when using telemedicine services, emphasizing the importance of care continuity.

Objective

This study aimed to explore the effects of cross-sectorial video consultation involving oncologists, general practitioners, and patients with cancer on patients’ perceived coordination of care, compared with usual care.

Methods

This study describes the primary outcomes from a 7-month follow-up of patients in the Partnership Project, a randomized clinical trial. Patients in the intervention group were randomized to receive a “partnership consultation,” a shared video consultation with an oncologist, general practitioners, and the patient, in addition to their usual care. Questionnaires were completed for both groups at baseline and 7 months to assess the primary outcome, “global assessment of inter-sectorial cooperation,” from the Danish questionnaire “Patients’ attitude to the health care service.” The questionnaire also included 2 single items and 5 index scales, examining patients’ attitude toward cooperation in the health care system. Change in perceived global coordination from baseline to 7 months was compared between intention-to-treat groups using generalized estimating equations in a linear regression model.

Results

A total of 278 participants were randomized with 1:1 allocation, with 80 patients receiving the intervention. Further, 210 patients completed the questionnaire at baseline, while 118 responded at 7-month follow-up. The estimated difference in the primary outcome between usual care (−0.13, 95% CI −0.38 to 0.12) and intervention (0.11, 95% CI −0.11 to 0.34) was 0.24 (95% CI −0.09 to 0.58) and not statistically significant (P=.15).

Conclusions

Low rates of intervention completion and high levels of missing data compromised the interpretability of our study. While we observed a high level of global assessment of coordination, the estimated intervention effect was smaller than anticipated, with no significant difference in perceived coordination between control and intervention groups. Future studies should explore strategies like patient incentives to increase response rate and improve the evaluation of this innovative health care model.
Health Equity of Hypertension Management Between Local Residents and Internal Migrants in Shenzhen, China: Cross-Sectional Study
Authors: He Jinyu , Li Yanjun , Zeng Huatang , Sun Haoran , Wu Liqun , Zhu Zhenzhen , Zhang Ning , Liang Wannian
Published: February 2025

Background

With hypertension emerging as a global public health concern, taking measures to alleviate its burden is urgently needed. The hypertension management program (HMP) in China is a standardized policy to help people with hypertension to improve their health levels and reduce health inequalities. However, studies focusing on details regarding participation in this program remain scarce.

Objective

This study aims to investigate the participation rates in HMPs in China and examine the health disparities in hypertension management between local residents and internal migrants in Shenzhen.

Methods

This study used the medical record of Shenzhen, Guangdong, China. We included adults with new-onset diagnosis of hypertension after 2017 and focused on patients who have a record in the community health center. We described the basic characteristics of people diagnosed with hypertension, including age, gender, marital status, occupation, education level, and health insurance type. Enrolled rate, follow-up rate, and adherence rate were used to measure the engagement with this program at the city, district, and community levels.

Results

Of the 1,160,214 hypertensive patients, 29.70% (344,526/1,160,214) were local residents, while 70.3% (815,688/1,160,214) were internal migrants. In addition, 55.36% (642,250/1,160,214) were enrolled in the HMP. Of those, 57.52% (369,439/642,25) were followed up. In addition, 62.59% (231,217/369,439) of followed up individuals were adherents. Internal migrants demonstrated a significantly higher participation in the HMP, especially for the enrolled rate (local residents: 156,085/344,526, 45.30% vs internal migrants: 486,165/815,688, 59.60%) and adherence rate (local residents: 44,044/84,635, 52.04% vs internal migrants: 187,173/284,804, 65.72%). Apart from that, local, single, and younger individuals had lower rates compared to their counterparts. There also existed within-district and within-community variation among enrolled, follow-up, and adherence rates.

Conclusions

Based on our research, individuals with different demographic and socioeconomic characteristics and in different regions had different enrolled, follow-up, and adherence rates. Internal migrants in Shenzhen showed a significantly higher participation in the HMP. Given these findings, there exists the potential to enhance the outreach and engagement of local, single, and younger populations through targeted promotional strategies.
Analysis of factors influencing unplanned extubation in children and implementation of nursing strategies (Preprint)
Authors: Xuefeng Han , Han Xuefeng
Published: February 2025

BACKGROUND

Unplanned extubation (UEX) serves as a crucial indicator for monitoring the quality of nursing care and can result in irreversible harm, impacting both adults and children. In adult Intensive Care Units (ICUs), the incidence of UEX generally ranges from 7% to 18%[23], with endotracheal tube extubation being associated with more severe consequences[24], occurring at a rate of 0.2%-14.6%[25]. For children, literature reports UEX occurrence rates of 1.18%-8.24%[18] and 3.7‰-5.0‰[6], with pediatric ICU rates ranging from 0.43% to 0.79%[1]. The occurrence of unplanned extubation adverse events can impact a child's treatment and surgical outcomes when re-intubation is not immediately feasible, leading to prolonged hospital stays, increased caregiver-patient conflicts, and compromised nursing quality.

OBJECTIVE

Objective: To analyze the high-risk factors of unplanned extubation in children and implement appropriate nursing strategies to reduce the incidence of adverse events related to unplanned extubation, ensuring clinical safety of pediatric patients.

METHODS

Methods: A retrospective study was conducted on pediatric patients who underwent surgery in general pediatrics from January 2018 to December 2023 and experienced unplanned extubation during hospitalization, excluding cases caused by mental illness.

RESULTS

Results: During the perioperative period, a total of 1977 days of intubation were recorded, including 1079 days with urinary catheters, 68 days with gastric tubes, 768 days with postoperative wound drainage tubes, 46 days with peripheral central venous catheters, and 8 days with CVCs. There were 13 instances of unplanned extubation, comprising 8 urinary catheters, 3 gastric tubes, and 2 postoperative wound drainage tubes. The rate of unplanned extubation was 6.58‰, and the re-intubation rate was 15.38%.

CONCLUSIONS

. The study indicates that unplanned extubation is associated with factors such as the child's own conditions, changes in body position comfort, methods of catheter fixation, timing and date of extubation, and the extent of nurse rounds and education. Therefore, enhancing nurses' awareness of risk prevention and adopting effective restraint measures, adjusting the frequency of adhesive fixation, and improving fixing equipment are key to reducing the risk of unplanned extubation in general pediatrics. Effective nursing strategies significantly lower the risk of unplanned extubatio
Efficacy and safety of a digital tapering intervention in patients prescribed opioids post-surgery: Protocol for a non-randomized cohort study. (Preprint)
Authors: Hjaltadottir Bergdís Elsa , Blöndal Anna Bryndís
Published: February 2025

BACKGROUND

More than 300 million surgical procedures are performed worldwide each year, and opioids remain a primary approach for managing acute postoperative pain. Studies have demonstrated that a significant number of patients do not discontinue opioid treatment and continue to use opioids for months or even years after surgery. Tapering and management of prescription opioids is a well-known practice and is a part of the current clinical guidelines on safe prescribing. Every patient should receive thorough monitoring, education and a tapering plan when prescribed with opioids or receiving refills after a prolonged treatment. There are, however, challenges associated with tapering, including close follow-up, patient education, clinician time, management knowledge level, withdrawal safety and much more. The evolution of follow-up through smartphone applications has shown promising results in some fields of medicine and patients are increasingly interested in the idea of using smartphone applications for follow-up.

OBJECTIVE

The objective of this study is to investigate the efficacy and safety of Prescriby as a tapering intervention in post-operative surgery patients.

METHODS

The efficacy will be measured in tapers successfully completed, doses successfully lowered during tapering, number of “active users”, satisfaction with the intervention and patients successfully remaining off opioid medication at 6 and 12 months after intervention. Participant safety will be monitored by assessing adverse effects during tapering using the Numeric Pain Rating Scale (NPRS) to assess the severity of pain.
Participants are recruited via referrals to the Prescriby Clinic from orthopedic clinics and orthopedics departments in the hospital after surgery during the 6 month study period, where they will receive a personalized tapering treatment and follow-up with a clinical pharmacist.

RESULTS

Despite the existence of numerous clinical guidelines on tapering off dependence-inducing medications, there is limited knowledge about the outcomes of such tapering.

CONCLUSIONS

This study protocol represents a key opportunity to generate new evidence. If the results of the research indicate that significant success has been achieved in tapering off high-risk medications using the applied methodology at the tapering clinic, it creates opportunities for further implementation of similar tapering programs in the Icelandic healthcare settings and beyond Icelandic borders.

CLINICALTRIAL
Co-Constructing an Evaluation of the Implementation of an Outreach Clinic for Opioid Use Disorders in Québec, Canada: Study Protocol (Preprint)
Authors: Paré-Plante Andrée-Anne , Fortin Laurence , Milot David-Martin , Langlois Catherine , Payette-Toupin Charlotte , Nguyen Bao Duyen Angéline , Poulin Sophie , Bertrand Karine , Leblanc Caroline , Maillet Lara , Racine-Hemmings François , Wilson Isabelle , Loignon Christine
Published: February 2025

BACKGROUND

The opioid overdose crisis currently affecting Canada has led to several thousand deaths. The COVID-19 pandemic has exacerbated the consequences of this crisis, particularly with the instability of the unregulated drug market. Québec is observing
a similar trend: the opioids consumed are more dangerous, and the number of overdoses is rising. Opioid use disorder (OUD) therefore represents a major public health issue. Offering appropriate interventions such as opioid agonist therapy integrated into primary care is one way of reducing the risk of death from overdose.

OBJECTIVE

The aim of this research is to evaluate the implementation of an outreach clinic offering a low-threshold treatment program for opioid use disorders in Québec. The secondary objective is to identify the factors that foster the participation of socially excluded people living or having lived with OUD in primary care research.

METHODS

This study is being conducted in the Montérégie region and comprises three phases: exploratory, photovoice and participatory evaluation. The qualitative research adopts a participatory approach by involving socially excluded people targeted by the clinic services (e.g. people experiencing homelessness and living with OUD). A committee of peer researchers, made up of experts in living with OUD, will be set up
and will hold 10 meetings at various stages of the research. Two participant profiles will be involved: (1) healthcare professionals and community workers who will take part in semi-structured interviews and (2) people living with or having lived with OUD, who will take part in the photovoice or peer researcher committee meetings.

RESULTS

The peer research committee was formed in Winter 2024, and by November 2024, five meetings had been held. As of November 2024, four photovoice sessions had been conducted and 14 healthcare professionals and community workers had participated in the semi-structured interviews. Preliminary results from different phases of this project were presented at the 2023 and 2024 North American Primary Care Research
Group (NAPCRG) Conferences, as well as at the 2024 International Society for the Study of Drug Policy (ISSDP) Conference.

CONCLUSIONS

The anticipated outcome is the establishment of an outreach clinic for opioid use disorders outside a major urban centre, with a range of services tailored to the needs of socially excluded people living with OUD. The co-construction of this clinic in collaboration with people living with or having lived with OUD will make it possible to respond adequately to their overall health needs and reduce the barriers to access that they may face in conventional care structures.
The eREACH Study: A Randomized Study of an eHEALTH Delivery Alternative for Cancer Genetic Testing for Hereditary Predisposition in Patients with Metastatic Cancers. (Preprint)
Authors: Lee Kimberley , McLeod Briana , Egleston Brian , Brown sarah , Howe Sarah , Fetzer Dominique , Gutstein Lauren , Cacioppo Cara , Clark Dana , Domchek Susan , Ebrahimzadeh Jessica , Falcone dana , Ofidis Demetrios , Griffin Hannah , Mim Rajia , Hernandez Santina , Fleisher Linda , Karpink kelsey , Selmani Enida , Tahsin Aysha , Wagner Lynne , Weinberg Michelle , Yi-Wen Kuang , Wood Elisabeth , Bradbury Angela
Published: February 2025

BACKGROUND

Germline BRCA1/2 testing has become a standard evidence-based practice, with established risk reduction and cancer screening guidelines for genetic carriers. With FDA approval for PARP inhibitors in patients with advanced breast, ovarian, pancreatic and prostate cancer, there is an additional therapeutic rationale for testing all breast, ovarian, pancreatic and prostate cancer patients for germline BRCA1/2 mutations. Yet, many at-risk patients do not have access to genetic services, leaving many genetic carriers unidentified.

OBJECTIVE

The eREACH study (A Randomized Study of an eHealth Delivery Alternative for Cancer Genetic Testing for Hereditary Predisposition in Metastatic Breast, Ovarian, Prostate and Pancreatic Cancer Patients) evaluates the effectiveness of a theoretically and stake-holder informed eHealth (e.g. digital) delivery alternative to traditional genetic counseling in patients with advanced breast and ovarian cancer referred for genetic testing to determine if they are candidate for a PARP inhibitor.

METHODS

The eREACH study is a randomized non-inferiority study using a 2x2 design to test the optimal way to deliver clinical genetic testing in patients with metastatic cancers. The traditional standard-of-care pre-test (visit 1) and post-test (visit 2: disclosure) counseling delivered by a genetic counselor are replaced with a self-directed patient-informed digital intervention.

RESULTS

As of January 2025, we have completed enrollment of 229 participants. Data analysis is ongoing and we expect the results to be published in June 2025.

CONCLUSIONS

Increasing indications for BRCA 1/2 testing creates a pressing need to evaluate alternative delivery models to increase access and uptake of BRCA1/2 testing, while maintaining adequate patient cognitive, affective and behavioral outcomes. The eREACH study evaluates the effectiveness of an interactive patient-centered digital intervention to deliver clinical genetic testing to patients with metastatic cancers. We expect this work will inform evidence-based guidelines and the standard-of-care for delivery of genetic testing and is designed to be broadly applicable and easily adaptable for other populations and settings even beyond oncology.

CLINICALTRIAL

This protocol was registered at clinicaltrials.gov (NCT04353973) on April 14, 2020.
The Role of Strategic Vigilance in Achieving Strategic Success
Authors: Kanabi Idrees Sadeq , Sulayman Sakar Fattah , Nader Azad Salih , Nanekeli Rebaz Jalal Ahmed , Sadiq Gazang Jameel
Published: February 2025

This study investigates the role of strategic vigilance in achieving strategic success, focusing on its impact on organizational performance, innovation capability, competitive advantage, and strategic success in private hospitals in Erbil, Kurdistan Region of Iraq. The research adopts a quantitative approach with data collected from 88 employees through structured questionnaires. Results indicate that strategic vigilance significantly enhances organizational outcomes, with leadership style, technological infrastructure, and resource availability moderating these effects. Using Hayes' Process Macro, the study underscores the importance of fostering a vigilant organizational culture supported by robust leadership and technological frameworks. Practical implications highlight the need for organizations to integrate vigilance into strategic planning for sustained success. Limitations and future research directions are discussed, emphasizing the need for longitudinal studies and expanded focus on additional moderating variables.
Propuesta de clasificación de los topónimos de las regiones insulares de México
Authors: Guerrero Gómez Ariadna Neith
Published: February 2025

Este artículo aborda la relevancia de la toponimia en el ámbito de la geografía, centrándose en un aspecto poco explorado: los nombres de los cuerpos insulares de México, que incluyen islas, cayos y arrecifes. Se destaca que, de los 4110 cuerpos insulares registrados y distribuidos en seis regiones, solo 1031 cuentan con un topónimo. Se presenta un ejercicio de clasificación basado en los criterios propuestos por autores como Anaya Monroy, Guzmán Betancourt y García Sánchez, así como una propuesta de clasificación propia que considera particularidades como las morfologías litorales (términos geomorfológicos y de la pareidolia), características biológicas (flora y fauna) o aspectos históricos y culturales (anécdotas, apellidos, construcciones, gentilicios, santorales). Se toma como caso de estudio el Golfo de México, el cual comprende 322 cuerpos insulares con topónimo y es una región en la que se identifican algunas homonimias, diferenciándolas con el uso de números romanos o puntos cardinales para facilitar su búsqueda. Asimismo, sobre este muestreo se analiza la evolución de los nombres de los cuerpos insulares a lo largo del tiempo, evidenciando cómo han cambiado en la cartografía histórica. Este estudio resalta la riqueza toponímica de las regiones insulares de México, así como la importancia de mantener actualizadas las bases de datos para una gestión precisa y cuidadosa de los nombres geográficos.
Arte y salud mental. Lady Gaga visible una vocación
Authors: Fortoul Van der Goes Teresa I.
Published: February 2025

Stefani Joanne Angelina Germanotta, known worldwide as Lady Gaga, is a singer, songwriter, and actress recognized for her flamboyant style and electronic pop music. Her unique approach and defiant attitude towards established norms have helped spread a powerful message of acceptance and empowerment, a message that has also helped her cope with personal challenges, such as depression and anxiety, issues that many people share.
ASSESSMENT OF INITIAL MATERIAL (BASE LINE) FOR CREATION OF THE VARIETIES OF SPRING TRITICALE IN THE CLIMATE OF VOLGO-VYATSKIY REGION
Authors:   Vyatka State Agricultural Academy, Lekontzeva T.A. , Yufereva N. I. ,   Vyatka State Agricultural Academy, Statzenko E.S. ,   Vyatka State Agricultural Academy
Published: February 2025

The article presents the results of the study of the varieties of spring triticale in the climate of the
Volga-Vyatka Region. Spring triticale is not cultivated in the Kirov Region. Introduction of new crop
into production is possible only with the help of new varieties corresponding to soil and climatic
conditions of the region. The Vyatka State Agricultural Academy Department of General Agriculture
and Plant Growing is breeding spring triticale. Period and place of the research: years 2016-2018,
on the territory of the experimental field (Kirov City), the plots with sod-podzol medium-loam soils;
object of research and assessment: assessment of 66 samples of hexaploid forms of spring triticale
from the world collection of the Federal Research Center of the All-Russian Institute of Plant Genetic
Resources Named after N. I. Vavilova; the samples differed from each other in ecological and geographical origin. Laying of nursery was conducted in accordance with the procedure of the study of
the Collection. Spring triticale variety Rovnya was taken as the standard. This variety was the recommended for the use in the Volga-Vyatka Region. Agroclimatic conditions during the period of the
research differed significantly from the average longstanding values in temperature and precipitation. This made it possible to study more fully their influence on the formation of structural elements
and crop yield of the studied triticale variety samples. For the period of 3 years on average, duration
of the vegetation period of the standard amounted to 93 days. Ripening of the 22 samples was up to
the standard. Differences in vegetation conditions affected the yield of spring triticale, which on average varied from 88.4 g/m2 (year 2016) to 553.5 g/m2 (year 2017). 9 samples significantly exceeded
the standard. They were of great value for the selection of highly productive forms (crop yield 335 –
368 g/m2). Ripening of the variety samples Sadko, Ruslo, Lana and Dublet was up to the standard
and provide a high crop yield. The purposeful inclusion of them in the breeding process is useful for
the creation of valuable source material.
MORPHOCHEMICAL CHANGES IN THE CONNECTIVE TISSUE OF THE ENDOMETRIUM OF PIGS
Authors:   Irkutsk Interregional Veterinary Laboratory, Siraziev Romazan Z.
Published: February 2025

The article presents histophysiological characteristics of structural elements of connective tissue of
endometrium of pigs in various sections of uterus horns during rut and different periods of pregnancy obtained
by methods of histomorphological and histochemical analysis. The investigation revealed species specific features, general and local structural and functional transformations of tissues components of connective tissue
bases of proper mucosa of endometrium occurred due to physiological changes of female body. Glycogen,
neutral glycoproteins, RNA, common and cationic proteins, lysine, histidine have been identified in connective
tissues elements.
الإطار التنظيمي لمؤسسات التمويل الأصغر الإسلامي في السعودية Regulatory Framework for Islamic Microfinance in Saudi Arabia
Authors: Al-Ansary Oussama Mohamed , Mohamad Mohammad Taqiuddin , Mohd Noh Mohd Shahid
Published: February 2025

The research examines the regulatory framework for Islamic microfinance in Saudi Arabia. The research aims to review the government supervisory and regulatory authorities for Islamic microfinance in Saudi Arabia, and to identify the most prominent regulations related to this sector. The research used a descriptive analytical approach, relying on tools for collecting and analyzing qualitative data such as interviews with Islamic microfinance relevant parties, analysis of related reports and documents, as well as benefiting from published reports from the relevant authorities. The research reached a number of findings, including the link between Islamic microfinance and the support of micro-enterprises with the targets of Saudi Vision 2030, the existence of several government supervisory and regulatory authorities for microfinance in Saudi Arabia that work closely to achieve the vision's targets, such as the Saudi Central Bank and the Social Development Bank, the issuance of numerous regulations related to microfinance in Saudi Arabia, and the existence of two types of Islamic microfinance in Saudi Arabia, including the developmental microfinance led by the Social Development Bank, and the commercial Islamic microfinance through banks and financial institutions supervised by the Saudi Central Bank.
واقع بيئة العمل الإبداعية في أكاديميات الإعلام الرقمي وفق أفضل الممارسات العالمية لإدارة المواهب The Reality of the Creative Work Environment In Digital Media Academies According to the Best International Practices For Talent Management
Authors: al-Hosni Isa bin Fadhil bin Saif , Kadir Fakhrul Adabi Abdul
Published: February 2025

This study aimed to identify the reality of the creative work environment represented by (organizational structure, training, technology, incentives, and working conditions) on talent management represented by (planning the workforce of talented people, motivating and developing talented workers, and evaluating the performance of talented workers) in academies. Digital media. The researcher followed the descriptive analysis method. The study derives its importance from researching the relationship of the creative work environment to talent management. The research was chosen due to the lack of organizations’ focus on knowing the importance of the creative work environment that may affect talent management and reflect on their creativity. Therefore, the problem of the study lies in answering the main question: What is the reality of the creative work environment in digital media academies according to the best international practices for talent management? The study was conducted on a random sample, and the study population consisted of all employees of digital media academies, who numbered (250) employees. The sample was selected and distributed electronically according to the sample size determination table developed by Cressy and Morgan, which consisted of (175) employees. The researcher designed a questionnaire to measure the study variables. The study concluded with a set of results, the most prominent of which is that there is a statistically significant effect at the significance level (0.05) of the creative work environment represented by (organizational structure, training, technology, incentives, working conditions) on talent management represented by (planning for a talented workforce, motivating... And developing talented workers, evaluating the performance of talented workers) in digital media academies. The study recommended many recommendations, the most prominent of which were: working to improve the work environment for employees in digital media academies, especially with regard to the organizational structure, training,... incentives, Do not overlook this as it is positively linked to talent management.
ALI SHARI’ATI ON DIVINE HUMANISM: INTEGRATION OF DIVINE VALUES IN THE FORMATION OF HUMAN IDENTITY
Authors: Hotmatua Paralihan
Published: February 2025

Divine Humanism, initiated by Ali Shari’ati, offers an integrative view of forming human identity based on divine values. In this view, humans are understood not only as material entities but also as spiritual beings with moral responsibilities towards themselves, society, and God. Shari’ati emphasizes that the unity between humans, nature, and God is the foundation for building a complete human identity. This study aims to explore and understand the concept of divine Humanism in Ali Shari’ati’s thought, focusing on key works such as Man and Islam, Religion vs. Religion, and Marxism and Other Western Fallacies. The study explores the core ideas, principles, and implications of divine Humanism and how divine values contribute to forming human identity. It found that humans are considered material and spiritual beings with moral responsibilities towards God, self, and society. The concept of tawhid, which emphasizes the unity of God, man, and nature, is the basis of a complete human identity. Shari’ati's divine humanism criticizes secularism and secular humanism, which ignore spirituality, fuel moral crises, ethical relativism, and alienation. As an alternative, he places divine values such as justice, compassion, and social responsibility at the core of human identity and the driver of social transformation. This study makes an important contribution to global social issues by offering Ali Shari‘ati’s divine humanism approach as a framework for understanding and overcoming the challenges of modernity, such as dehumanization, moral crisis, and ethical relativism.
CONTRASTING PARADIGMS: BETWEEN CAPRA’S ECO-LITERACY AND MULYADHI’S TRILOGY IN ADDRESSING THE ECOLOGICAL CRISIS
Authors: Suwendi  , Tanzila Feby Nur Aini
Published: February 2025

This research explores the philosophical views of Fritjof Capra and Mulyadhi Kartanegara regarding nature, aiming to shift the anthropocentric reasoning of modern humans. The dominance of Western thought in the modern world, characterized by rationalism, materialism, and empiricism, has led to a lack of spiritual awareness. This mechanistic paradigm causes modern humans to perceive nature as a mere object, operating like a machine without spirituality, thus reducing it to an instrument for human exploitation. Consequently, this perspective fosters exploitative behaviors that contribute to the ongoing ecological crisis. To address this issue, Capra and Kartanegara propose new paradigms that prioritize not only human interests but also the well-being of the universe as a whole. Although they employ different approaches, both thinkers offer alternative paradigms emphasizing the unity of nature, respect for living beings, and human responsibility in maintaining ecological balance. Capra bases his views on modern science and ecology from a holistic perspective, while Kartanegara draws from Islamic theology and classical philosophy. This research is based on a literature study that examines the writings of both scholars alongside relevant secondary sources.
Game-based visual feedback-guided dynamic balance training versus conventional training in patients with hemiplegia: a pilot randomized controlled trial
Authors: Xu Yan , Ni Jiadong , Yang Yajing , Yao Jiajia , Fu Lianhui , Xu Cong
Published: February 2025

Objective: This study aimed to compare the efficacy of game-based visual feedback-guided dynamic balance training with conventional training in patients with hemiplegia.
Design: Single-blind, pilot randomized controlled trial.
Patients: Fifty-three patients with hemiplegia exhibiting balance dysfunction at ≥  1 month were enrolled.
Methods: The experimental group (n = 25) trained with the Physio Space™ system that uses a 3-axis balancing platform and touchscreen monitor to provide visual feedback during 9 game modules at varying challenge levels for 20 min per day, 5 days per week, for 3 weeks. The control group (n = 28) received traditional training for the same duration. To evaluate the efficacy of the training, a 2-way repeated-measures analysis of variance (ANOVA) was used. The study protocol was registered on the Chinese Clinical Trial Registry (ChiCTR2300067275, https://www.chictr.org.cn).
Results: Eighteen participants in each group completed the training programme, with no baseline between-group differences. The post-training assessment revealed significant improvements (Berg Balance Scale, Functional Reaching Test, Timed “Up-and-Go” Test scores and 10-metre fast walking speed) in outcome measures in the full sample. After training, no between-group differences were observed in the tests.
Conclusion: Our results indicate that game-based visual feedback with dynamic balance training has effects comparable to those of conventional balance training in patients with hemiplegia.
Microgratings fabricated with laser-induced plasma-assisted deposition and laser subtractive patterning
Authors: Fan Lisha , Li Jie , Wang Yuting , Zhang Shuowen , Wu Ling , Zhao Tianzhen , Ding Xiaoyu , Wu Huaping , Yao Jianhua
Published: February 2025

Laser-induced plasma-assisted deposition (LIPAD) is an efficient and low-cost method for processing thin films on transparent substrates, but it is difficult to control in terms of edge evenness, chemical composition homogeneity, and geometric precision. Here, a donor target of stainless steel 316 is used in the LIPAD process to fabricate a homogenous thin film on a glass plate. The effects of laser parameters on the structural and chemical characteristics of the films are systematically investigated. The experimental results show that the density of spherical particles reduces and the particle size shrinks as laser scanning distance increases. The influence of laser scanning distance on the chemical structures of LIPAD films is studied by Raman spectroscopy and x-ray diffraction. Microgratings with precisely defined size are fabricated from the LIPAD thin films by a laser subtractive patterning step, and grating constants retrieved from the optical diffraction experiment match well with the measured strip spacing, envisioning the feasibility of LIPAD in efficient production of microgratings.
När krisen eller kriget kommer. Förskolans rektorer som ledare och samhällsaktörer i särskilt utsatta områden
Authors: Eidevald Christian , Palmer Anna
Published: February 2025

Artikeln undersöker förskolans beredskap för krissituationer, som skjutningar, sprängningar, bilbränder och pandemier, genom intervjuer med elva rektorer i särskilt utsatta områden. Med stöd i det multiteoretiska ramverket Cynefin analyseras ledarskapshandlingar som används i olika typer av krissituationer, som inkluderar gängvåld och rykten och deras påverkan på förskolans beredskap. Studien visar att närvaron i förskolor i särskilt utsatta områden kan sjunka till så låga nivåer som 10–15% under krissituationer, vilket förstärker de långsiktiga negativa konsekvenserna för barns utveckling och lärande. Rektorernas förmåga att anpassa sig till olika sammanhang lyfts, där kriser innebär ökad arbetsbelastning och brist på tid för reflektion. Analysen visar att specifika ledarskapshandlingar och verktyg behövs för att få barn att komma tillbaka till förskolan efter en kris, hantera misstänksamhet mot samhället och spridning av rykten. Långsiktig och hållbar beredskap betonas. Slutsatsen är att mångfacetterade ledarskapshandlingar krävs för att hantera krisartade sammanhang inom förskolor i särskilt utsatta områden, som flexibla ledarskapshandlingar, samarbete och anpassad kommunikation för olika målgrupper. 
ENGLISH ABSTRACT
When Crisis or War Strikes: Preschool Managers as Community Actors in Particularly Vulnerable Areas
This study explores preschool crisis preparedness, focusing on how preschool managers in particularly vulnerable areas describe handle crises such as gang violence, pandemics, and other community disruptions. Using the Cynefin framework, which integrates knowledge management and complexity science, the article examines the leadership strategies used in simple, complicated, complex, and chaotic situations. Through interviews with eleven preschool managers in Sweden, the study highlights the significant challenges posed by crises in vulnerable areas, where decreased child attendance during such events threatens support for language and other developmental skills crucial for children most in need. The findings emphasize the importance of adaptive leadership, including the ability to make rapid decisions, manage communication with parents who have varying levels of language proficiency and literacy, and address mistrust and rumors within the community. The study concludes that effective crisis management in preschools requires collaboration, flexibility, and context-specific strategies to ensure long-term crisis preparedness. The role of preschools in maintaining safety and community cohesion during crises is critical, especially in preventing the escalation of societal divides and ensuring that preschools continue to serve as safe havens for children in vulnerable areas.
Fostering Environmental Awareness Character in Elementary Education Through the Economic Green Living Approach
Authors: Retno Raras Setyo , Yuhanna Wachidatul Linda , Utami Sri
Published: February 2025

The global issue of environmental degradation necessitates education that fosters environmental awareness among students from an early age. Green living is an effective learning approach to cultivate students' environmental concern while simultaneously developing their independence. This study aims to analyze the development of environmental awareness among elementary school students through the economic green living approach, which applies the 5R principles: refuse, reuse, recycle, reduce, and replant. This research employs a descriptive qualitative method, with data collected through observation, interviews, and documentation. The collected data were analyzed using the interactive model by Miles and Huberman, which involves data reduction, data presentation, and continuous conclusion drawing. The results reveal that the implementation of the 5R principles among students includes activities such as waste recycling, greening, reusing discarded items, waste reduction, and rejecting plastic bags. The process cultivates characteristics such as independence, responsibility, discipline, creativity, and collaborative skills. This study concludes that the economic green living approach, utilizing the 5R principles, is effective in shaping students’ environmental awareness while equipping them with life skills relevant to addressing environmental sustainability challenges.