bluuebunny/crossref_metadata_2025 huggingface dataset:
Performing Screw Fixation for Femoral Neck Fractures under Local Anaesthesia
Authors: Chor-Yat Chung , Sze-Hung Wong
Published: October 2012

Background

Many patients who suffer from hip fractures have multiple medical comorbidities and there are risks when undergoing spinal or general anaesthesia. In fact, screw fixation can be performed under local anaesthesia infiltration for undisplaced femoral neck fracture, thus enabling patients for early mobilisation and rehabilitation.

Methods

Ten patients had screw fixation performed under local anaesthesia. Parameters including pain tolerability, operation time, time to mobilisation after operation, hospital stay, and surgical outcomes were measured.

Results

All 10 patients were able to complete the operation under local anaesthesia with minimal pain during the intraoperative period. No extra sedation, any form of intraoperative analgesia, or conversion to other form of anaesthesia was needed. No local wound or implant-related complication was detected in the early postoperative period. An average of 23.1 months (range: 17–28 months) follow-up showed all fractures had healed without any implant-related complications or avascular necrosis of the femoral head.

Conclusion

Screw fixation can be performed safely under local anaesthesia in selected patients who have high-risk of spinal or general anaesthesia in order to accelerate their rehabilitation.
Deep carbon cycle and geodynamics: the role of the core and carbonatite melts in the lower mantle
Authors: Dobretsov N.L. , Shatskiy A.F.
Published: October 2012

Carbon, though being abundant in the Solar system, barely exceeds 0.01 wt.% in the silicate mantle, whereas it is ~ 3.6 wt.% in primitive chondritic meteorites that most likely formed our planet. This deficit may be due to redistribution of carbon in the liquid metal phase and then in the core at the stage of magma ocean fractionation, because carbon is much more soluble in Fe–Ni ± S melt than in silicate melts. The terrestrial heat and mass transfer are controlled mainly by layered convection and periodic peaks of plume activity as fast mantle jets that rise from the core. Plumes carry significant amounts of CO2, H2O, and K2O (most probably in the form of carbonatite or hydrous carbonatite melts) released by the degassing core on its interaction with oxidized silicate material. There are two mechanisms that may maintain fast plume ascent: (1) local melting at the plume front as a result of doping with volatiles (H2O, CO2) as in a gas burner (rise rate 60–110 cm/yr) or (2) flow controlled by diffusion transport of silicate components in carbonatite melt (rise rate ~ 100 cm/yr).
Seismic geologic structure model for the sedimentary cover of the Laptev Sea part of the Lomonosov Ridge and adjacent parts of the Amundsen Plain and Podvodnikov Basin
Authors: Rekant P.V. , Gusev E.A.
Published: October 2012

Seismic data on the southern (Laptev Sea) extremity of the Lomonosov Ridge were used to develop a new structural model for the sedimentary cover. It permitted a correlation between the seismic cross-sections of the ridge crest and two deep-sea basins: the Podvodnikov Basin and the Amundsen Plain. It is the first time that a seismic model has taken into account both regional seismic-reflection profiles obtained from NP drifting ice stations and recent high-resolution CDP data. Our seismic model agrees both with geological data on the Laptev Sea continental margin and the data obtained from deep-sea drilling into the Lomonosov Ridge under the IODP-302 project. The sedimentary cover of the southern Lomonosov Ridge and adjacent parts of the Amundsen Plain and Podvodnikov Basin was dated at the Aptian–Cenozoic. The sedimentary section is divided by two main unconformities, of Campanian–Paleocene and Oligocene–Early Miocene ages. The cover contains a structurally complicated graben system, which is an extension of the New Siberian system of horsts and grabens, recognized in the shelf. Sedimentation began in the grabens in the Aptian–Albian and ended with their complete compensation in the Paleocene.
Neoproterozoic alkaline magmatism and associated igneous rocks in the western framing of the Siberian craton: petrography, geochemistry, and geochronology
Authors: Romanova I.V. , Vernikovskaya A.E. , Vernikovsky V.A. , Matushkin N.Yu. , Larionov A.N.
Published: October 2012

The formation and evolution conditions for alkaline magmatism and associated igneous rocks in the western framing of the Siberian craton are shown by the example of alkaline and subalkaline intrusive bodies of the Yenisei Ridge. Here we present petrographic, mineralogical, geochemical, and geochronological data for the rocks of the Srednetatarka and Yagodka plutons located within the Tatarka–Ishimba suture zone. Ferroan and metaluminous varieties enriched with rare elements (Nb, Ta, Zr, Hf, and REE) are making up most of the studied rocks. They formed at the stages of fractional crystallization of alkaline magma in a setting of active continental margin in the west of the Siberian craton in the Late Neoproterozoic (710–690 Ma). As differentiates of mantle magmas, these rocks associate with Nb-enriched rocks—A-type leucogranites and carbonatites. Sm/Nd and Rb/Sr isotopic data imply a predominance of the mantle component in the magmatic sources of the mafic and intermediate rocks as well as contamination processes of various volumes of continental crustal material by this magma.
Paleomagnetism of trap basalts in the northwestern Siberian craton, from core data
Authors: Mikhaltsov N.E. , Kazansky A.Yu. , Ryabov V.V. , Shevko A.Ya. , Kuprish O.V. , Bragin V.Yu.
Published: October 2012

We present new paleomagnetic data for continental flood basalts (Siberian traps) obtained from cores of two boreholes in the northwestern Noril’sk area, within the Kharaelakh and Vologochan basins. Paleomagnetic measurements of lava and tuff samples from KhS-59 and SSV-19 boreholes allowed reconstructing and correlating the polarity patterns. Thus multiple paleomagnetic anomalies (PMA) have been discovered as brief polarity changes in narrow intervals of the magnetostratigraphic section above the principle reversal at the boundary between the Ivakin and Syverma Formations.

The most prominent anomalies are observed at the bases of the Morongo and Mokulai Formations. The samples from the anomalous intervals differ from those of other intervals neither in rock magnetic properties, nor in mineralogy and magnetic grain sizes. Therefore, the revealed PMA record excursions of the geomagnetic field. Comparison of the results with the Meishan Global Stratotype Section and Point (GSSP) of the Permian–Triassic boundary implies a revision to the P–T position in the trap basalt succession of the Noril’sk area. Judging by the EMF behavior, basalts in this part of the trap province erupted for at least 500 kyr during an interval of stable normal polarity.
Management of High Altitude Pulmonary Edema in the Himalaya: A Review of 56 Cases Presenting at Pheriche Medical Aid Post (4240 m)
Authors: Jones Barbara E. , Stokes Suzy , McKenzie Suzi , Nilles Eric , Stoddard Gregory J.
Published: October 2012

Objective

The purpose of this study was to review the patient characteristics and management of 56 cases of high altitude pulmonary edema at the Pheriche Himalayan Rescue Association Medical Aid Post, and to measure the use of medications in addition to descent and oxygen.

Methods

In a retrospective case series, we reviewed all patients diagnosed clinically with high altitude pulmonary edema during the 2010 Spring and Fall seasons. Nationality, altitude at onset of symptoms, physical examination findings, therapies administered, and evacuation methods were evaluated.

Results

Of all patients, 23% were Nepalese, with no difference in clinical features compared with non-Nepalese patients; 28% of all patients were also suspected of having high altitude cerebral edema. Symptoms developed in 91% of all patients at an altitude higher than the aid post (median altitude of onset of 4834 m); 83% received oxygen therapy, and 87% received nifedipine, 44% sildenafil, 32% dexamethasone, and 39% acetazolamide. Patients who were administered sildenafil, dexamethasone, or acetazolamide had presented with significantly lower initial oxygen saturations ( P ≤ .05). After treatment, 93% of all patients descended; 38% descended on foot without a supply of oxygen.

Conclusions

A significant number of patients presenting to the Pheriche medical aid post with high altitude pulmonary edema were given dexamethasone, sildenafil, or acetazolamide in addition to oxygen, nifedipine, and descent. This finding may be related to perceived severity of illness and evacuation limitations. Although no adverse effects were observed, the use of multiple medications is not supported by current evidence and should not be widely adopted without further study.
Disability and Job Search Among Older Workers: A Narrative Review
Authors: Hutton Mathew , Bohle Philip , Mc Namara Maria
Published: October 2012

This article reviews published research on the effects of disability, age and gender on the job search process. Electronic databases (Medline [via Ovid], OT Seeker, CINAHL, AMED, and Proquest 5000) were used to identify studies focusing on job search and employment, disability, age, gender and other barriers to workforce participation. There has been extensive research on the effects of age and gender on the job search process, and the available evidence indicates that disability, age and gender play significant roles in shaping the job search processes of older workers. However, there has been little rigorous investigation of the role of disability and research specifically examining the relationships between disability, job search behaviours and employment outcomes was not identified. This is a significant gap in the literature on disability and participation in the labour market. Overall, this narrative review indicates that older workers with a disability face multiple disadvantages when seeking work, which impairs their ability to fully engage in the labour market.
In vitrodetermination of dietary protein and amino acid digestibility for humans
Authors: Butts Christine A. , Monro John A. , Moughan Paul J.
Published: October 2012

The development, refinement and validation ofin vitrodigestibility assays for dietary protein and amino acids for single stomached mammals are reviewed. The general principles ofin vitrodigestibility assays and their limitations are discussed.In vitroprotein digestibility assays must be accurate, rapid, cheap, simple, robust, adaptable and relevant to the processes of digestion, absorption, and metabolism. Simplein vitromethods have the potential to give useful measures ofin vivoamino acid and protein digestibility for humans.In vitromethods, including the complex multi-component models of digestion simulating the various physical and chemical processes, require independent validation within vivodata from the target species or an acceptable animal model using the most appropriatein vivomeasure of digestibility. For protein sources devoid of anti-nutritional factors or plant fibre, true ileal digestibility is the recommendedin vivobaseline, while for plant proteins the recommendedin vivoassay is real ileal digestibility. More published comparative studies are required to adequately validatein vitrodigestibility assays.
Amino acid requirements in children and the elderly population
Authors: Pillai Raja R. , Kurpad Anura V.
Published: October 2012

The factorial approach is used to measure the dietary indispensable amino acid (IAA) requirements in children, although recent measurements based on the indicator amino acid oxidation (IAAO) method have begun to generate more direct evidence. Difficulties with the factorial method are that it depends on accurate estimates of the maintenance protein requirement, as well as of protein deposition during growth. Also, a value for the efficiency of utilizing dietary protein for deposition has to be selected, based on published Nitrogen (N) balance studies. In the recent 2007 WHO/FAO/UNU report, the amino acid requirement pattern for infants was taken to be similar to the amino acid composition of breast milk. For pre-school and older children, the factorial method gave values for the scoring pattern of protein that were fairly close to the earlier 1985 WHO/FAO/UNU report for children, since growth progressively became a smaller component of the factorial calculation as age progressed. However, given that there are several assumptions in the derivation of factorial estimates, direct experimental measurements of the amino acid requirement are desirable. The IAAO method, as it is non-invasive, as made it possible to measure the IAA requirements in children. Over the last decade, some of the IAA requirements have been determined by using the IAAO method in healthy school age children; however, the data on IAA requirements in developing country populations are still being conducted. In the elderly, there are not enough data to make a separate recommendation for IAA requirements from that of adults.
The regulation of protein content and quality in national and international food standards
Authors: Lewis Janine L.
Published: October 2012

Food regulation aims to protect public health through a safe and nutritious food supply produced by a compliant food industry. Food standards of developed countries generally do not regulate protein content or protein quality because the risk of dietary protein inadequacy in their national populations is very low. Protein is nevertheless regulated for reasons of product quality or protein labelling or to minimise assessed health risks associated with consumption of certain animal- and vegetable-protein foods; analogue products that extend or simulate commonly available animal-protein foods; and special purpose foods such as infant formula and foods, supplementary and medical foods, and foods for weight loss. The extent and approach to protein regulation varies greatly among jurisdictions but where it occurs, it is applied through minimum and sometimes maximum limits on protein content or quality measures or both using an inter-related approach. Protein quality measures range from amino acid profiles and digestibility corrected scores to protein rating, a rat bioassay and reference proteins not further described. Regulatory methods for protein quality determination are referenced to the published scientific literature or developed nationally. Internationally, the Codex Alimentarius regulates the protein content and quality of some foods. The Codex approach varies according to the food but is similar to the approaches used in national and regional food regulation. This paper provides a comparison of the regulation of protein in foods using examples from the food regulations of Australia New Zealand, Canada, the European Union, the United States of America and the Codex Alimentarius.
Identifying recommended dietary allowances for protein and amino acids: a critique of the 2007 WHO/FAO/UNU report
Authors: Millward D. Joe
Published: October 2012

The WHO/FAO/UNU (2007) report examines dietary protein and amino acid requirements for all age groups, protein requirements during pregnancy, lactation and catch-up growth in children, the implications of these requirements for developing countries and protein quality evaluation. Requirements were defined as the minimum dietary intake which satisfies the metabolic demand and achieves nitrogen equilibrium and maintenance of the body protein mass, plus the needs for growth in children and pregnancy and lactation in healthy women. Insufficient evidence was identified to enable recommendations for specific health outcomes. A meta analysis of nitrogen balance studies identifies protein requirements for adults 10 % higher than previous values with no influence of gender or age, consistent with a subsequently published comprehensive study. A new factorial model for infants and children, validated on the basis of the adequacy of breast milk protein intakes and involving a lower maintenance requirement value, no provision for saltatory growth and new estimates of protein deposition identifies lower protein requirements than in previous reports. Higher values for adult amino acid requirements, derived from a re-evaluation of nitrogen balance studies and new stable isotope studies, identify some cereal-based diets as being inadequate for lysine. The main outstanding issues relate to the biological implausibility of the very low efficiencies of protein utilisation used in the factorial models for protein requirements for all population groups especially pregnancy when requirements may be overestimated. Also considerable uncertainty remains about the design and interpretation of most of the studies used to identify amino acid requirement values.
Available versus digestible dietary amino acids
Authors: Rutherfurd Shane M. , Moughan Paul J.
Published: October 2012

Available amino acids are those absorbed from the gastrointestinal tract in a form suitable for body protein synthesis. True ileal digestible amino acids are determined based on the difference between dietary amino acid intake and unabsorbed dietary amino acids at the terminal ileum. The accuracy of ileal digestible amino acid estimates for predicting available amino acid content depends on several factors, including the accuracy of the amino acid analysis procedure. In heat processed foods, lysine can react with compounds to form nutritionally unavailable derivatives that are unstable during the hydrochloric acid hydrolysis step of amino acid analysis and can revert back to lysine causing an overestimate of available lysine. Recently, the true ileal digestible reactive (available) lysine assay based on guanidination has provided a means of accurately determining available lysine in processed foods. Methionine can be oxidised during processing to form methionine sulphoxide and methionine sulphone and cysteine oxidised to cysteic acid. Methionine sulphoxide, but not methionine sulphone or cysteic acid, is partially nutritionally available in some species of animal. Currently, methionine and cysteine are determined as methionine sulphone and cysteic acid respectively after quantitative oxidation prior to acid hydrolysis. Consequently, methionine and cysteine are overestimated if methionine sulphone or cysteic acid are present in the original material. Overall, given the problems associated with the analysis of some amino acids in processed foodstuffs, the available amino acid content may not always be accurately predicted by true ileal amino acid digestibility estimates. For such amino acids specific analytical strategies may be required.
Food proteins as a source of bioactive peptides with diverse functions
Authors: Rutherfurd-Markwick Kay J.
Published: October 2012

In addition to supplying essential nutrients, some food proteins can confer additional health benefits beyond nutrition. The presence of bioactive proteins and peptides in different foods is a factor not currently taken into consideration when assessing the dietary quality of food proteins. The range of described physiological benefits attributed to bioactive proteins and peptides is diverse. Multiple factors can potentially impact on the ability of a bioactive peptide or protein to elicit an effect. Although some food proteins act directly in their intact form to elicit their effects, generally it is peptides derived from digestion, hydrolysis or fermentation that are of most interest. The levels of bioactive peptides generated must be sufficient to elicit a response, but should not be so high as to be unsafe, thus causing negative effects. In addition, some peptides cause systemic effects and therefore must be absorbed, again in sufficient amounts to elicit their action. Many studies to date have been carried outin vitro; therefore it is important that further trials are conductedin vivoto assess efficacy, dose response and safety of the peptides, particularly if health related claims are to be made. Therefore, methods must be developed and standardised that enable the measurement of health benefits and also the level of bioactive peptides which are absorbed into the bloodstream. Once standardised, such methods may provide a new perspective and an additional mechanism for analysing protein quality which is currently not encompassed by the use of the protein digestibility-corrected amino acid score (PDCAAS).
Advantages and limitations of the protein digestibility-corrected amino acid score (PDCAAS) as a method for evaluating protein quality in human diets
Authors: Schaafsma Gertjan
Published: October 2012

PDCAAS is a widely used assay for evaluating protein quality. It is a chemical score, which is derived from the ratio between the first limiting amino acid in a test protein and the corresponding amino acid in a reference amino acid pattern and corrected for true faecal N digestibility. Chemical scores exceeding 100 % are truncated to 100 %. The advantages of the PDCAAS are its simplicity and direct relationship to human protein requirements. The limitations are as follows: the reference pattern is based on the minimum amino acid requirements for tissue growth and maintenance and does not necessarily reflect the optimum intake. Truncated PDCAAS of high-quality proteins do not give any information about the power of these proteins to compensate, as a supplement, for low levels of dietary essential amino acids in low-quality proteins. It is likely that faecal N digestibility does not take into account the loss from the colon of indispensable amino acids that were not absorbed in the ileum. Anti-nutritional factors, such as lectins and trypsin inhibitors, in several plant protein sources can cause heightened endogenous losses of amino acids, an issue which is particularly relevant in animal feedstuffs. The assumption that amino acid supplementation can completely restore biological efficiency of the protein source is incorrect since the kinetics of digestion and absorption between supplemented free amino acids and amino acids present in dietary proteins, are different.
Assessment of protein adequacy in developing countries: quality matters
Authors: Ghosh Shibani , Suri Devika , Uauy Ricardo
Published: October 2012

Dietary protein and amino acid requirement recommendations for normal “healthy” children and adults have varied considerably with 2007 FAO/WHO protein requirement estimates for children lower, but dietary essential AA requirements for adults more than doubled. Requirement estimates as presented do not account for common living conditions, which are prevalent in developing countries such as energy deficit, infection burden and added functional demands for protein and AAs. This study examined the effect of adjusting total dietary protein for quality and digestibility (PDCAAS) and of correcting current protein and AA requirements for the effect of infection and a mild energy deficit to estimate utilizable protein (total protein corrected for biological value and digestibility) and the risk/prevalence of protein inadequacy. The relationship between utilizable protein/prevalence of protein inadequacy and stunting across regions and countries was examined. Data sources (n = 116 countries) included FAO FBS (food supply), UNICEF (stunting prevalence), UNDP (GDP) and UNSTATS (IMR) and USDA nutrient tables. Statistical analyses included Pearson correlations, paired-sample/non-parametric t-tests and linear regression. Statistically significant differences were observed in risk/prevalence estimates of protein inadequacy using total protein and the current protein requirements versus utilizable protein and the adjusted protein requirements for all regions (p < 0·05). Total protein, utilizable protein, GDP per capita and total energy were each highly correlated with the prevalence of stunting. Energy, protein and utilizable protein availability were independently and negatively associated with stunting (p < 0·001), explaining 41 %, 34 % and 40 % of variation respectively. Controlling for energy, total protein was not a statistically significant factor but utilizable protein remained significant explaining~45 % of the variance (p = 0·017). Dietary utilizable protein provides a better index of population impact of risk/prevalence of protein inadequacy than crude protein intake. We conclude that the increased demand for protein due to infections and mild to moderate energy deficits, should be appropriately considered in assessing needs of populations where those conditions still prevail.
Dietary changes in obese patients undergoing gastric bypass or lifestyle intervention: a clinical trial
Authors: Johnson Line K. , Andersen Lene F. , Hofsø Dag , Aasheim Erlend T. , Holven Kirsten B. , Sandbu Rune , Røislien Jo , Hjelmesæth Jøran
Published: October 2012

We compared changes in the dietary patterns of morbidly obese patients undergoing either laparoscopic gastric bypass surgery or a comprehensive lifestyle intervention programme. The present 1-year non-randomised controlled trial included fifty-four patients in the lifestyle group and seventy-two in the surgery group. Dietary intake was assessed by a validated FFQ. ANCOVA was used to adjust for between-group differences in sex, age, baseline BMI and baseline values of the dependent variables. Intakes of food groups and nutrients did not differ significantly between the intervention groups at baseline. At 1-year follow-up, the lifestyle group had a significantly higher daily intake of fruits and vegetables (561 (sd 198) v. 441 (sd 213) g, P= 0·002), whole grains (63 (sd 24) v. 49 (sd 16) g, P< 0·001) and fibre (28 (sd 6) v. 22 (sd 6) g, P< 0·001) than the surgery group and a lower percentage of total energy intake of saturated fat (12 (sd 3) v. 14 (sd 3) %, P< 0·001). The intake of red meat declined significantly within both groups, vegetables and fish intake were reduced significantly in the surgery group and added sugar was reduced significantly in the lifestyle group. The lifestyle patients improved their dietary patterns significantly (compared with the surgery group), increasing their intake of vegetables, whole grains and fibre and reducing their percentage intake of saturated fat (ANCOVA, all P< 0·001). In conclusion, lifestyle intervention was associated with more favourable dietary 1-year changes than gastric bypass surgery in morbidly obese patients, as measured by intake of vegetables, whole grains, fibre and saturated fat.
Enigmatic sedimentary structures in the Lower Old Red Sandstone, south Wales, UK: possible microbial influence on surface processes and early terrestrial food webs
Authors: MARRIOTT SUSAN B. , HILLIER ROBERT D. , MORRISSEY LANCE B.
Published: October 2012

Several enigmatic sedimentary structures are present in Upper Silurian and Lower Devonian terrestrial rocks of south Wales. These are millimetre ripples, wrinkle structures, ‘cauliflower’ and ‘molehill’ structures, calcretized matgrounds, ‘pepper-pots’ and ‘fairy rings’. Most of the structures occur on fine-grained sandstone bedding surfaces in both inclined and non-inclined red heterolithic deposits that form a large part of the Lower Old Red Sandstone in south Wales. These deposits consist of conspicuous units up to 3 m thick, comprising millimetre- to centimetre-scale laminasets of alternating mudstone and fine-grained sandstone, interpreted as muddy point bars on ephemeral channel margins, crevasse-splay lobes or distal flood-out deposits from ephemeral flow. They are rich in trace fossils reflecting animal locomotion, burrowing, foraging, ploughing and resting. Millimetre ripples and wrinkle structures are related to rapid growth of cyanobacterial mats on wet sediment surfaces, especially in films of standing water, that may have been a critical constituent of the food chain for terrestrial communities. Pustular ‘cauliflower’ and ‘molehill’ structures are preserved on tuffs and have been linked to algal blooms formed following an increase in nutrients due to ashfall into floodplain ponds. The tuffs are associated with a diverse ichnofauna indicating that opportunist colonizers took advantage of an abundant food source.
The XM25 Individual Airburst Weapon System: A ‘Game Changer’ for the (Law on the) Battlefield? Revisiting the Legality of Explosive Projectiles under the Law of Armed Conflict
Authors: Ruys Tom
Published: October 2012

In the summer of 2010, the US Army began the field-testing of a new weapon, the XM25 ‘Individual Semi-Automatic Airburst System’, which fires ‘airburst’ anti-personnel rounds that can be programmed to detonate at a certain distance. While the XM25 has been heralded as a ‘game changer’ for modern warfare, the question nonetheless remains to what extent it is compatible with the law of armed conflict (LOAC). Against this background, this article aims to examine the legality of the XM25, in particular having regard to the customary prohibition on certain explosive projectiles and the general prohibition on causing superfluous injury and unnecessary suffering.
IHL 2.0: Is There a Role for Social Media in Monitoring and Enforcement?
Authors: Herzberg Anne , Steinberg Gerald M
Published: October 2012

This article will examine the opportunities and limitations of using social media in the execution of legal duties relating to the monitoring and enforcement of IHL. The article will first provide an overview of social media. Next, it will briefly summarise the normative framework of IHL as well as the legal duties of the primary actors and promoters of IHL (for example, states, the UN, NGOs, the International Committee of the Red Cross and courts) to monitor and enforce these rules. The article will then address specific legal obligations relating to IHL monitoring and enforcement and the impact of social media on meeting these requirements.

Throughout, the article will use case studies from several conflict zones, including Sudan, Uganda, Mexico, Somalia, Gaza and Libya. The article will conclude that social media can play a critical role in promoting IHL education, and monitoring for potential violations. The benefits of this technology, however, are less clear for carrying out legal obligations related to the enforcement of IHL, such as fact-finding, arrest and prosecution. It is essential, therefore, that clear guidelines for utilising this quickly evolving technology, particularly in official fact-finding and judicial frameworks, be established.
The parasite fauna of the Patagonian toothfish Dissostichus eleginoides off the Falkland Islands
Authors: Brown J. , Brickle P. , Scott B.E.
Published: October 2012

The parasite fauna of juvenile Dissostichus eleginoides, while they inhabit the Falkland's shelf, was examined, giving new detailed information on spatial, ontogenic and seasonal variations. A total of 24,943 parasites from 15 different taxa were found in the stomach of 502 individual fish. Parasite species composition and abundance allowed separation of toothfish by area between the north-west and south-east of the Falklands. The digenean, Elytrophalloides oatesi, and the nematodes, Hysterothylacium spp. and Anisakis spp., were the most common, all with a prevalence >20%. For some seasons ontogenic changes in abundance were significant in these three parasite taxa, and this is discussed in terms of ontogenic and seasonal changes in diet. Elytrophalloides oatesi and Hysterothylacium spp. showed spatial and seasonal differences in abundance with greater numbers in the warmer waters of the north-west and during the summer months. Differences in abundance of E. oatesi between the Falklands and other regions indicate its potential for use as a biological tag to study toothfish movements and population structure; however, more seasonal data would be required before this technique could be used.
Vitamin D, type 2 diabetes and other metabolic outcomes: a systematic review and meta-analysis of prospective studies
Authors: Khan Hassan , Kunutsor Setor , Franco Oscar H. , Chowdhury Rajiv
Published: October 2012

Vitamin D status may influence the risk of developing metabolic diseases such as Type 2 diabetes (T2D), metabolic syndrome (MetS) and insulin resistance (IR). Several studies have assessed vitamin D in relationship with metabolic outcomes; however, results remain inconsistent. A systematic review and meta-analysis using multiple databases (MEDLINE, Web of Science and EMBASE), was performed up to 10 August 2012. Prospective studies reporting association of circulating or dietary vitamin D with incident T2D, MetS and IR outcomes were included. Relative risks (RR) were pooled using random effects and subgroup analysis by pertinent study-level characteristics was performed. A total of seventeen articles based on eighteen unique prospective studies, and comprising 210 107 participants with 15 899 metabolic events, collected during a median follow up of 10 years (range 3–22 years), were included. RR for individuals in top v. bottom thirds of baseline vitamin D were 0·81 (95% CI 0·71, 0·92); 0·86 (95% CI 0·80, 0·92); and 0·84 (95% CI 0·64, 1·12) for T2D, MetS and IR outcomes, respectively. Moderate heterogeneity was found between fourteen studies (I2 = 67%, P < 0·001) reporting on T2D. Findings were generally consistent across various study-level characteristics. In conclusion, vitamin D status at baseline in apparently healthy adults is inversely associated with future risks of T2D and MetS. Interventions aimed at maintaining adequate levels of vitamin D in addition to preventing deficiency may be a useful preventive measure for metabolic diseases. However, reliable evidence from carefully designed intervention studies, particularly those based on healthy populations, is needed to confirm observational findings.
Intestinal schistosomiasis in chimpanzees on Ngamba Island, Uganda: observations on liver fibrosis, schistosome genetic diversity and praziquantel treatment
Authors: STANDLEY C. J. , MUGISHA L. , ADRIKO M. , ARINAITWE M. , RUKUNDO J. , AJAROVA L. , MOPYA S. , BETSON M. , KABATEREINE N. B. , STOTHARD J. R.
Published: October 2012

Despite treatment with praziquantel (PZQ) at 40 mg/kg in food, several chimpanzees on Ngamba Island Chimpanzee Sanctuary (NICS) continue to excrete eggs of Schistosoma mansoni. To monitor disease, 8 animals were closely examined under anaesthesia in March 2011 with portable ultrasonography and by rectal snip biopsy. Schistosome genetic diversity had been previously assayed within 4 of these chimpanzees, finding extensive diversity with 27 DNA barcodes encountered, although none was common to all animals. Calcified schistosome eggs were found in the rectal snips from 5 chimpanzees and liver fibrosis was clearly documented, indicative of progressive disease in 6 animals, the latter being surprisingly advanced in a younger chimpanzee. All 8 animals were treated under anaesthesia by oral gavage with PZQ at 60 mg/kg dosing that was well tolerated. These animals were again re-examined in June 2012 using stool and urine sampling. Only 1 chimpanzee appeared to be free from infection and active egg excretion was confirmed in 6 animals. If intestinal schistosomiasis is to be controlled within this setting, a long-term disease management plan is required which should combine active case-detection with an insistent treatment regime with praziquantel for these chimpanzees, exploring perhaps the performance of even higher dosing.
Parasol cell mosaics are unlikely to drive the formation of structured orientation maps in primary visual cortex
Authors: HORE VICTORIA R.A. , TROY JOHN B. , EGLEN STEPHEN J.
Published: October 2012

The receptive fields of on- and off-center parasol cell mosaics independently tile the retina to ensure efficient sampling of visual space. A recent theoretical model represented the on- and off-center mosaics by noisy hexagonal lattices of slightly different density. When the two lattices are overlaid, long-range Moiré interference patterns are generated. These Moiré interference patterns have been suggested to drive the formation of highly structured orientation maps in visual cortex. Here, we show that noisy hexagonal lattices do not capture the spatial statistics of parasol cell mosaics. An alternative model based upon local exclusion zones, termed as the pairwise interaction point process (PIPP) model, generates patterns that are statistically indistinguishable from parasol cell mosaics. A key difference between the PIPP model and the hexagonal lattice model is that the PIPP model does not generate Moiré interference patterns, and hence stimulated orientation maps do not show any hexagonal structure. Finally, we estimate the spatial extent of spatial correlations in parasol cell mosaics to be only 200–350μm, far less than that required to generate Moiré interference. We conclude that parasol cell mosaics are too disordered to drive the formation of highly structured orientation maps in visual cortex.
Preface to the special issue: commutativity of algebraic diagrams
Authors: MATTHES RALPH , SOLOVIEV SERGEI
Published: October 2012

The problem of the commutativity of algebraic (categorical) diagrams has attracted the attention of researchers for a long time. For example, the related notion of coherence was discussed in Mac Lane's homology book Mac Lane (1963), see also his AMS presidential address Mac Lane (1976). Researchers in category theory view this problem from a specific angle, and for them it is not just a question of convenient notation, though it is worth mentioning the important role that notation plays in the development of science (take, for example, the progress made after the introduction of symbolic notation in logics or matrix notation in algebra). In 1976, Peter Freyd published the paper ‘Properties Invariant within Equivalence Types of Categories’ (Freyd 1976), where the central role is played by the notion of a ‘diagrammatic property’. We may also recall the process of ‘diagram chasing’, and its applications in topology and algebra. But before we can use diagrams (and the principal property of a diagram is its commutativity), it is vital for us to be able to check whether a diagram is commutative.
Shuffles and concatenations in the construction of graphs
Authors: DOŠEN KOSTA , PETRIĆ ZORAN
Published: October 2012

This paper reports on an investigation into the role of shuffling and concatenation in the theory of graph drawing. A simple syntactic description of these and related operations is proved to be complete in the context of finite partial orders, and as general as possible. An explanation based on this result is given for a previously investigated collapse of the permutohedron into the associahedron, and for collapses into other less familiar polyhedra, including the cyclohedron. Such polyhedra have been considered recently in connection with the notion of tubing, which is closely related to tree-like finite partial orders, which are defined simply here and investigated in detail. Like the associahedron, some of these other polyhedra are involved in categorial coherence questions, which will be treated elsewhere.
Coherence in monoidal track categories
Authors: GUIRAUD YVES , MALBOS PHILIPPE
Published: October 2012

We introduce homotopical methods based on rewriting on higher-dimensional categories to prove coherence results in categories with an algebraic structure. We express the coherence problem for (symmetric) monoidal categories as an asphericity problem for a track category and use rewriting methods on polygraphs to solve it. The setting is extended to more general coherence problems, viewed as 3-dimensional word problems in a track category, including the case of braided monoidal categories.
Identification of Mild Cognitive Impairment in ACTIVE: Algorithmic Classification and Stability
Authors: Cook Sarah E. , Marsiske Michael , Thomas Kelsey R. , Unverzagt Frederick W. , Wadley Virginia G. , Langbaum Jessica B.S. , Crowe Michael
Published: October 2012

Rates of mild cognitive impairment (MCI) have varied substantially, depending on the criteria used and the samples surveyed. The present investigation used a psychometric algorithm for identifying MCI and its stability to determine if low cognitive functioning was related to poorer longitudinal outcomes. The Advanced Cognitive Training of Independent and Vital Elders (ACTIVE) study is a multi-site longitudinal investigation of long-term effects of cognitive training with older adults. ACTIVE exclusion criteria eliminated participants at highest risk for dementia (i.e., Mini-Mental State Examination < 23). Using composite normative for sample- and training-corrected psychometric data, 8.07% of the sample had amnestic impairment, while 25.09% had a non-amnestic impairment at baseline. Poorer baseline functional scores were observed in those with impairment at the first visit, including a higher rate of attrition, depressive symptoms, and self-reported physical functioning. Participants were then classified based upon the stability of their classification. Those who were stably impaired over the 5-year interval had the worst functional outcomes (e.g., Instrumental Activities of Daily Living performance), and inconsistency in classification over time also appeared to be associated increased risk. These findings suggest that there is prognostic value in assessing and tracking cognition to assist in identifying the critical baseline features associated with poorer outcomes. (JINS, 2012, 18, 1–15)
Genetic gap analysis of wildHordeumtaxa
Authors: Vincent Holly , von Bothmer Roland , Knüpffer Helmut , Amri Ahmed , Konopka Jan , Maxted Nigel
Published: October 2012

To facilitate the updating ofin situandex situconservation strategies for wild taxa of the genusHordeumL., a combined ecogeographic survey and gap analysis was undertaken. The analysis was based on the Global Inventory of Barley Plant Genetic Resources held by ICARDA plus additional datasets, resulting in a database containing 17,131 wildHordeumaccessions. The analysis concluded that a genetic reserve should be established in the Mendoza Province of Argentina, as this is the most species-rich area globally forHordeum. A network of reserves should also be set up across the Fertile Crescent in Israel, Palestine, Syria, Jordan, Lebanon and Turkey to provide effective conservation within the centres of diversity for gene pools 1B (Hordeum vulgaresubsp.spontaneum(C. Koch) Thell.) and 2 (Hordeum bulbosumL.). The majority of the species were deemed under-collected, so further collecting missions are required worldwide where possible. Althoughex situandin situconservation strategies have been developed, there needs to be further investigation into the ecological environments thatHordeumspecies occupy to ensure that any adaptive traits expressed are fully conserved. Additionally, studies are required to characterize existing collections and test the viability of rare species accessions held in genebanks to determine whether furtherex situcollections are required alongside the proposedin situconservation.
Kognitive Verhaltenstherapie bei Depressionen im Kindes- und Jugendalter
Authors: Groen Gunter , Petermann Franz
Published: October 2012

Die Kognitive Verhaltenstherapie (KVT) bietet einen theoretisch und empirisch gut abgeleiteten Therapieansatz bei depressiven Kindern und Jugendlichen. Ihre Anwendung bei dieser Indikation ist gemäß vorliegenden Leitlinien und Wirksamkeitsstudien zu empfehlen. Vor allem im Hinblick auf die bisher ermittelten nur kleineren bis moderaten Effektgrößen sowie fehlenden Befunde zur langfristigen Wirksamkeit und zu Wirkfaktoren sind jedoch zusätzliche Forschung und konzeptionelle Weiterentwicklung erforderlich. Der Artikel gibt zunächst einen kurzen Überblick über Grundlagen und Inhalte der KVT bei depressiven Kindern und Jugendlichen. Im Weiteren werden neuere Befunde und Einschätzungen zu ihrer Wirksamkeit sowie aktuelle Weiterentwicklungen und Perspektiven vorgestellt.
Prevalence and Comorbidities of Adolescent Depression in Germany
Authors: Hoffmann Falk , Petermann Franz , Glaeske Gerd , Bachmann Christian J.
Published: October 2012

Objective: Data on the prevalence of depressive disorders in adolescents are scarce. We aimed to examine the administrative prevalence of depressive disorders and related comorbidities in German adolescents. A second objective of was to assess potential regional (East vs. West Germany) differences in depression prevalence. Method: Data of a statutory health insurance company were analysed and outpatients from 12 to 18 years of age with diagnosed depression during a one-year-period (2009) were identified. Results: The population at risk consisted of 140,563 adolescents. Of these, 4,295 (41.2% male; mean age: 15.5 years) had a diagnosis of depression. This equates to a prevalence of 3.1% (females: 3.7%, males: 2.5%). There were no significant differences between East and West Germany. Of all adolescents with depression, 62.5% had at least one comorbid psychiatric diagnosis, with anxiety and emotional disorders (23.7%), somatoform disorders (16.8%), hyperkinetic disorders (16.2%) and posttraumatic stress disorder (10.0%) being most frequently diagnosed. Conclusions: The depression prevalence in this sample was lower than that in studies of clinical samples. There was a marked prevalence of psychiatric comorbidities, especially of internalizing disorders. In adolescents, the risk of depression seems to be comparable in both East and West Germany.
Development of a microbial contamination susceptibility model for private domestic groundwater sources
Authors: Hynds Paul D. , Misstear Bruce D. , Gill Laurence W.
Published: October 2012

Groundwater quality analyses were carried out on samples from 262 private sources in the Republic of Ireland during the period from April 2008 to November 2010, with microbial quality assessed by thermotolerant coliform (TTC) presence. Assessment of potential microbial contamination risk factors was undertaken at all sources, and local meteorological data were also acquired. Overall, 28.9% of wells tested positive for TTC, with risk analysis indicating that source type (i.e., borehole or hand‐dug well), local bedrock type, local subsoil type, groundwater vulnerability, septic tank setback distance, and 48 h antecedent precipitation were all significantly associated with TTC presence (p < 0.05). A number of source‐specific design parameters were also significantly associated with bacterial presence. Hierarchical logistic regression with stepwise parameter entry was used to develop a private well susceptibility model, with the final model exhibiting a mean predictive accuracy of >80% (TTC present or absent) when compared to an independent validation data set. Model hierarchies of primary significance are source design (20%), septic tank location (11%), hydrogeological setting (10%), and antecedent 120 h precipitation (2%). Sensitivity analysis shows that the probability of contamination is highly sensitive to septic tank setback distance, with probability increasing linearly with decreases in setback distance. Likewise, contamination probability was shown to increase with increasing antecedent precipitation. Results show that while groundwater vulnerability category is a useful indicator of aquifer susceptibility to contamination, its suitability with regard to source contamination is less clear. The final model illustrates that both localized (well‐specific) and generalized (aquifer‐specific) contamination mechanisms are involved in contamination events, with localized bypass mechanisms dominant. The susceptibility model developed here could be employed in the appropriate location, design, construction, and operation of private groundwater wells, thereby decreasing the contamination risk, and hence health risk, associated with these sources.