bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and optimization of DPC-crosslinked HPβCD nanosponges for entrectinib oral delivery: formulation, characterization, and pharmacokinetic studies
Authors: Reddy Konda Sri Chaya , Bhikshapathi Darna
Published: August 2024

Background

In advanced or metastatic cancers characterized by specific genetic alterations, heightened growth and resistance to conventional therapies are common. Targeted treatments like entrectinib (ENT) precisely inhibit aberrant signaling pathways, potentially enhancing outcomes. The objective of this research is to develop and enhance the effectiveness of entrectinib-loaded nanosponge formulations by utilizing hydroxypropyl-β-cyclodextrin (HPβCD) to improve its oral bioavailability.

Results

The study employed surface response methodology and Design-Expert® software to optimize key formulation variables such as the molar concentration ratio of the polymer and cross-linker, as well as process variables such as stirring speed and duration. Optimization focused on particle size, polydispersity index, and percentage entrapment efficiency. Validation methods encompassed Fourier transform spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), in vitro release studies, and in vivo studies.

After optimization, ENT-loaded HPβCD NSPs were formulated with a molar ratio (P:CL) of 0.800 mg, stirred at 3000 rpm for 420 min, achieving a desirability of 0.926. Predicted values for PS (particle size), PdI (polydispersity index), and EE % (entrapment efficiency) were 146.98 nm, 0.263, and 88.29%, respectively. The optimized formulation showed a mean size of 151.8 ± 5.6 nm, PDI of 0.233 ± 0.049, and EE of 87.36 ± 1.61%. Further validation through various analyses confirmed the optimization's efficacy, with notable improvements demonstrated in AUC0-t (6.30-fold) and Cmax (4.10 times) compared to the free drug.

Conclusion

The findings of the study indicated that nanosponges exhibit promise as an effective carrier for delivering entrectinib, addressing for advance tumor effectively by enhancing release and bioavailability in the treatment of cancer.
Shared patient information and trust: a qualitative study of a national eHealth system
Authors: Lundhaug Kristine , Faxvaag Arild , Stokke Randi , Andreassen Hege Kristin
Published: August 2024

Background

In Norway, as in other countries, national eHealth systems, such as the Summary Care Record (SCR), have been implemented to improve the collaboration around patients by sharing patient information between health professionals across healthcare institutions and administrative levels. Although widely implemented across the health and care services in Norway, evaluations of the SCR indicate less use than expected. There is a need for analysis that lays out the visions and expectations of the SCR and contrasts these with detailed observations of use in everyday health professional work. This study adds to the eHealth research field by exploring this reality.

Method

This paper has a qualitative design with an ethnographic approach, including participant observation, qualitative interviews, and a document review. Qualitative individual interviews with 22 health professionals and six weeks of participant observation were conducted, and eight documents were reviewed. The field notes and the interview-transcriptions were analyzed following a stepwise-deductive induction analysis.

Results

The document review identified the expectations and visions of the SCR, including an underlying assumption of trust in shared patient information. However, this assumption is implicit and not recognized as a crucial element for success in the documents. In our observation and interview data, we found that health professionals do not necessarily trust information in the SCR. In fact, several procedures and routines to assess the trustworthiness of SCR information were identified that complicate and disturb the expected use. In our analysis, two main themes characterize the health professionals' handling of the SCR: adapting to workflow and dealing with uncertainty.

Conclusion

Our study illustrates that unconditional trust in shared patient information is an implicit assumption in SCR policy documents, but in their everyday work health professionals do not necessarily unconditionally trust shared patient information. Rather, sharing patient information through technology, such as the SCR, requires of health professionals to critically assess the digital information. The information in the SCR, as all sources of information presented to health professionals, becomes an item for their constant trust-work. Our study is of value to policymakers, health information systems developers, and the field of practice both nationally and internationally.
The genome sequence of the Purple Clay moth, Diarsia brunnea (Denis & Schiffermüller) 1775
Authors: Davis Jo , Menzies Dougie ,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: August 2024

We present a genome assembly from an individual male Diarsia brunnea (the Purple Clay moth; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence has a total length of 586.80 megabases. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 15.29 kilobases in length. Gene annotation of this assembly on Ensembl identified 18,730 protein-coding genes.
Investigation of the Rare Fraction of Flora in the Projected Landscape Reserve "Balka Shchurivska"
Authors: Kyiak Svitlana , Kyiak Pavlo
Published: August 2024

The study investigates the current distribution of rare plant species within the ravine system "Balka Shchurivska" and provides justification for granting the site protected area status. The research examines the presence of rare plant species listed in the Red Book of Ukraine, the Red List of Dnipropetrovsk Oblast, and international conservation lists. Field surveys conducted from 2020-2023 revealed the presence of 26 regionally rare plant species, 13 species listed in the Red Book of Ukraine, 3 species from Resolution 6 of the Bern Convention and annexes of the Habitats Directive represented in Ukraine's flora, and 1 species from the IUCN Red List. Notable rare species found include Pulsatilla pratensis, Adonis vernalis, and Stipa capillata. The study highlights the importance of the area for biodiversity conservation and recommends its designation as a landscape reserve of national importance.
Vasyl Dzhevinsky: Return from Oblivion - A Pioneer in Desert Agriculture and Afforestation
Authors: Kyiak Svitlana , Soldatenko Halyna , Kyiak Pavlo
Published: August 2024

Background. Vasyl Mykolayovych Dzhevinsky, born in Verkhniodniprovsk in 1879, was an outstanding scientist, forester, and agronomist who laid the foundations for desert agriculture development in the Aral Sea region. His pioneering work in afforestation and plant cultivation under harsh desert conditions remained unknown in his homeland for a long time. Material and methods. The article is based on the analysis of Dzhevinsky's autobiographical manuscript covering the period from 1898 to 1953, as well as additional historical research. Results. Dzhevinsky developed an innovative method of cultivating plants in trenches in the desert, which allowed for effective afforestation and vegetable cultivation in an extremely dry climate. His work contributed to transforming the Chelkar station into a flourishing oasis, with orchards, gardens, and vineyards. Conclusions. Dzhevinsky's achievements in desert agronomy and forestry had a significant impact on agricultural development in the Aral Sea region. His story illustrates the potential of innovation in overcoming challenging environmental conditions and highlights the importance of restoring the memory of forgotten scientists.
Code and Data Repository for A Shrinkage Approach to Improve Direct Bootstrap Resampling Under Input Uncertainty
Authors: Song Eunhye , Lam Henry , Barton Russell R.
Published: August 2024

The goal of this software is to demonstrate the shrinkage bootstrap methods for input uncertainty quantification proposed in "A Shrinkage Approach to Improve Direct Bootstrap Resampling under Input Uncertainty" by Eunhye Song, Henry Lam, and Russell Barton accepted for publication at INFORMS Journal on Computing.
Ranking Model Averaging: Ranking Based on Model Averaging
Authors: Feng Ziheng , He Baihua , Xie Tianfa , Zhang Xinyu , Zong Xianpeng
Published: August 2024

Ranking problems are commonly encountered in practical applications, including order priority ranking, wine quality ranking, and piston slap noise performance ranking. The responses of these ranking applications are often considered as continuous responses, and there is uncertainty on which scoring function is used to model the responses. In this paper, we address the scoring function uncertainty of continuous response ranking problems by proposing a ranking model averaging (RMA) method. With a set of candidate models varied by scoring functions, RMA assigns weights for each model determined by a K-fold crossvalidation criterion based on pairwise loss. We provide two main theoretical properties for RMA. First, we prove that the averaging ranking predictions of RMA are asymptotically optimal in achieving the lowest possible ranking risk. Second, we provide a bound on the difference between the empirical RMA weights and theoretical optimal ones, and we show that RMA weights are consistent. Simulation results validate RMA superiority over competing methods in reducing ranking risk. Moreover, when applied to empirical examples—order priority, wine quality, and piston slap noise—RMA shows its effectiveness in building accurate ranking systems.

History: Accepted by Ram Ramesh, Area Editor for Data Science and Machine Learning.

Funding: This research was supported by the Beijing Municipal Natural Science Foundation [Grant 1222002], the National Natural Science Foundation of China [Grants 12071457, 12201018, 12301364, 71925007, 72091212, and 72273120], National Quality Infrastructure [Grant 2022YFF0609903], the Chinese Academy of Sciences Project for Young Scientists in Basic Research [Grant YSBR-008], and the Natural Science Foundation of Anhui Province [Grant 2308085QA09].

Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://doi.org/10.1287/ijoc.2023.0257 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2023.0257 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Developing critical enquiry, capacity, capability and confidence in the health and care workforce
Authors: Whitehouse Claire L , Webster Jonathan , Copping Jacky , Morris Paul , Yazbek Jonathan , Shiju Mehar , Hall Helen
Published: August 2024

Background:

Health and care staff have limited opportunities to design, deliver and lead critical enquiry activities.

Aims:

To explore barriers and enablers of building capacity, capability and confidence of these practitioners who wish to undertake critical enquiry activity.

Methods:

A realist conceptual framework including the development of middle range theory allowed analysis of the scholarship process and outcomes. Data were collected through snap surveys, interviews (face to face and online) and project output (posters).

Results:

Nine scholars completed the programme and all participated in the study. They all experienced an increase in capacity, capability and confidence in critical enquiry activity. Six overarching themes arose from analysis of the interviews and snap survey data: value; expertise; attitudes; meaningful, responsive support; brain space; and skill and knowledge acquisition.

Discussion:

A combined focus on people and project while staff remained embedded in their work area was key for the growth of skills and knowledge and creating impact from projects. Guilt at having dedicated time to take part in the programme was a self-imposed barrier to building capacity and capability. Social capital (gained from bringing together individuals from different groups with shared values) facilitated bonding, which increased psychological safety and helped enable capability and confidence.

Conclusion:

The combination of theory and practice embedded in a real-world context led to positive outcomes for staff, patients, carers and the facilitation team as real-life changes were made in clinical environments.
Why enjoyment is vital to nursing
Authors: Foster Sam
Published: August 2024

Sam Foster, Executive Director of Professional Practice, Nursing and Midwifery Council, considers research on why nurses enjoy nursing and why this is important for job satisfaction and nurse retention
Performance of a silicone foam dressing in management of wounds in a community setting: a sub-analysis of the VIPES study
Authors: Colboc Hester , Ayoub Nayla , Pegalajar-Jurado Adoración , Schueller Romain , Armstrong Florence
Published: August 2024

Objective:

Managing the gap between the dressing and the wound bed can facilitate the healing of exuding wounds. A silicone foam dressing (Biatain Silicone; Coloplast A/S, Denmark) was developed for application to exuding wounds. A sub-analysis of the real-world, prospective, observational VIPES (Observatoire en Ville des Plaies ExSudatives) study was conducted to investigate the use and performance of the silicone foam dressing in a community nursing setting in France.

Method:

The sub-analysis included patients from the VIPES study who received the silicone foam dressing as a primary dressing for an acute or hard-to-heal (chronic) wound. Epidemiological and wound healing outcomes were reported via a smartphone application.

Results:

Overall, 64 patients were included in the sub-analysis. At baseline, most wounds (n=33/40; 82.5%) were in treatment failure (i.e., were stagnant, non-healing or had poor exudate management). At the last follow-up visit, a median of 22.5 (range: 3–151) days post baseline, 48.4% of wounds had healed and 25.0% were progressing towards healing. From baseline to the last follow-up visit, significant reductions in exudate level (p<0.0001) and exudate pooling (p<0.0001), and significant improvements in wound edges (p≤0.0001) and periwound skin (p<0.01) were observed. A total of 62.3% of patients had re-epithelialising wounds at the last follow-up visit. The majority of nurses (88.3%) and patients (85.0%) reported that the wound had improved and, at most dressing removals (93.5%), nurses reported that the dressing conformed closely to the wound bed.

Conclusion:

Overall, the data suggest that use of the silicone foam dressing in community practice supported the healing of wounds, illustrating the importance of exudate and gap management.
An Automated On-The-Go Unloading System Reduces Harvest Operator Stress Relative to Manual Operation
Authors: Burgers Travis A. , Kamarei Kusha , Vora Mukund , Horne Matthew
Published: August 2024

Highlights

Stress was measured in harvest operators who performed on-the-go unloading manually and with an automated system.

Automated unloading reduced the average grain cart and combine operator stress rate by 18% and 12%, respectively, compared to manual operation.

Harvest operators usually worked more than 9 hours and often worked more than 12 hours per workday during harvest.

The use of automated unloading systems could positively affect the health of harvest operators.

Abstract. On-the-go unloading improves harvest operational efficiency, but it requires skilled labor because it is challenging and stressful to balance numerous concurrent tasks. Harvest automation reduces workload, stress, and fatigue. The objective of this study was to determine if using a commercially available, automated on-the-go unloading system (Raven Cart AutomationTM, RCA, Raven Industries) would reduce operator stress compared to manual operation. Nine grain cart tractor operators and six combine operators participated in this study. Operators performed their typical harvest operation, except to alternate on-the-go unloading using RCA or operating manually. Skin conductance (electrodermal activity) was measured with an Empatica E4 wristband, and stressful events were quantified. Machine data was collected from the tractor and combine via CAN logs. Over 200 total unload events were analyzed. Grain cart and combine operators using RCA had an 18% (p = 0.022) and 12% (p = 0.18) reduction in stress rate, respectively, compared to operating the grain cart tractor manually. RCA reduced the tractor cross-track error standard deviation by 2.5 cm on straight passes (p < 0.0001). The use of an automated on-the-go unloading system reduces operator stress during harvest and could positively affect the health of operators, especially during the long harvest workdays. Keywords: Agricultural workers, Combine operators, Custom harvesters, Electrodermal activity, Grain cart operators, Guidance systems, Harvest, Skin conductance, Stress, Vehicle automation.
Critical values for body mass index related to morbidity in high-volume low-complexity general surgery: a systematic review and meta-analysis
Authors: Hajibandeh S , Hajibandeh S , Harries K , Lewis WG , Egan RJ
Published: August 2024

Introduction

The aim of this study was to investigate the effect of body mass index (BMI, kg/m2) on outcomes of high-volume low-complexity (HVLC) general surgery procedures and to determine critical values for BMI when selecting patients into HVLC programmes.

Methods

A systematic review was conducted of studies looking at patients in different BMI categories undergoing HVLC general surgery procedures (laparoscopic cholecystectomy, inguinal hernia repair and umbilical or paraumbilical hernia repair), in accordance with the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) guidelines. A comparison meta-analysis model was constructed to compare the outcomes using random-effects modelling. The QUIPS (Quality In Prognosis Studies) tool and GRADE (Grading of Recommendations Assessment, Development and Evaluation) system were used to assess bias.

Results

A total of 26 studies including 486,392 patients were examined. In laparoscopic cholecystectomy, BMI ≥40 was associated with higher conversion to open surgery (odds ratio [OR]: 1.33, p=0.040) but did not affect complications (OR: 0.69, p=0.400) or length of hospital stay (mean difference [MD]: −0.01 days, p=0.900). In inguinal hernia repair, BMI ≥35 was associated with longer operative time (MD: 18.00 minutes, p<0.00001), and higher risk of wound complications (OR: 3.01, p<0.00001) and hospital readmission (OR: 1.46, p=0.0008). In umbilical or paraumbilical hernia repair, BMI ≥30 was associated with higher risk of wound complications (OR: 6.45, p<0.0001) and hospital readmission (OR: 5.56, p<0.00001), and longer operative time (MD: 4.01 minutes, p=0.030).

Conclusions

Obesity was associated with longer operative time (up to 23 minutes) and higher risk of postoperative morbidity (up to 4-fold) in HVLC procedures. BMI <40 (moderate GRADE certainty – laparoscopic cholecystectomy) and BMI <35 (moderate GRADE certainty – inguinal hernia) appear to represent optimal critical values for perioperative safety metrics.
Supra-inguinal Fascia Iliaca Block and the Obturator Nerve Obsession
Authors:   Department of Anaesthesia, Sancheti Institute of Orthopaedic and Rehabilitation, Pune, Maharashtra, India., Diwan Sandeep , Feigl Georg ,   Department of Anatomy and Clinical Morphology, Witten / Herdecke University, Witten, Germany., S Shivaprakash ,   Department of Anatomy, JSS Medical College, JSS Academy of Higher Education and Research, Mysore, Karnataka State, India
Published: August 2024

To the Editor, Anatomic block efficacy of lumbar plexus elements is based upon the involvement of the obturator nerve. However, despite the anatomic location of the obturator nerve and improbable translocation of local anesthetic beyond the confinement of the fascia iliacus plane [1], investigators struggle to study extensively, exhaustively, and try to explicitly describe the means and mechanism to block the obturator nerve [2]. Our anatomical dissections reveal three important dissimilar fascial planes (figure 1a). The quadratus lumborum, the fascia iliaca, and the circum-psoas planes are isolated from each other with tight fascial attachments [Figure 1b], impeding the dissemination of local anaesthetic agents unless inadvertently perforating the fascia. Further exploration revealed the femoral, lateral femoral cutaneous, obturator nerves and the lumbosacral trunk emerge from the lateral and medial of the psoas muscle respectively, and exits the psoas fascia (figure 1a,1b, and 1c) to take their respective course. The obturator nerve might further arise in a separate muscular fold (Figure 1c). However, if the obturator nerve needs to be blocked, two we recommend two alternatives; We presume that with injections deep to the psoas sheath, the plausibility of involvement of all the nerves of the lumbar plexus (lateral femoral cutaneous nerve, femoral nerve, and ON) exists, as reported in a case series [3] and the obturator nerve needs to be blocked separately after a supra-inguinal fascia iliaca block.
Sweet Archipelagos: Sugar, Empires, and the Making of a Transpacific Insect Trail
Authors: Shen Weijia Vicky
Published: August 2024

Abstract: In 1854, a whaling vessel brought two bundles of sugarcane from Tahiti to Maui, marking the beginning of the Lahaina cane's history and the socioecological transformation of the Hawaiian Islands and the Asia-Pacific. This essay tells a history of sugar through the transpacific crossings of three nonhuman species: sugarcane, the sugarcane beetle borer, and the tachinid fly. It situates nonhuman actors within the historical context of plantation agriculture, capitalist imperialism, and biological globalization of the nineteenth- and twentieth-century Pacific to reconceptualize entomological categories like "pest" and "parasite." Engaging with actor-network theory, animal studies, and island studies, the essay attempts to offer insights into historical agency, human–nonhuman relations, and large-scale ecological change.
Perspectives and challenges in developing and implementing integrated dengue surveillance tools and technology in Thailand: a qualitative study
Authors: Rotejanaprasert Chawarat , Armatrmontree Peerawich , Chienwichai Peerut , Maude Richard J.
Published: August 2024

Background

Dengue remains a persistent public health concern, especially in tropical and sub-tropical countries like Thailand. The development and utilization of quantitative tools and information technology show significant promise for enhancing public health policy decisions in integrated dengue control. However, the effective implementation of these tools faces multifaceted challenges and barriers that are relatively underexplored.

Methods

This qualitative study employed in-depth interviews to gain a better understanding of the experiences and challenges of quantitative tool development and implementation with key stakeholders involved in dengue control in Thailand, using a phenomenological framework. A diverse range of participants, including public health workers and dengue control experts, participated in these interviews. The collected interview data were systematically managed and investigated using thematic analysis to extract meaningful insights.

Results

The ability to collect dengue surveillance data and conduct ongoing analyses were contingent upon the availability of individuals possessing essential digital literacy and analytical skills, which were often in short supply. Furthermore, effective space-time early warning and precise data collection were hindered by the absence of user-friendly tools, efficient reporting systems, and complexities in data integration. Additionally, the study underscored the importance of the crucial role of community involvement and collaboration among organizations involved in integrated dengue surveillance, control and quantitative tool development.

Conclusions

This study employed a qualitative approach to gain a deeper understanding of the contextual intricacies surrounding the development and implementation of quantitative tools, which, despite their potential for strengthening public health policy decisions in dengue control, remain relatively unexplored in the Thai context. The findings yield valuable insights and recommendations for the development and utilization of quantitative tools to support dengue control in Thailand. This information also has the potential to support use of such tools to exert impact beyond dengue to a broader spectrum of diseases.
Comparison of cardiovascular disease risk association with metabolic unhealthy obesity identified by body fat percentage and body mass index: Results from the 1999–2020 National Health and Nutrition Examination Survey
Authors: Xiong Qian , Zhang Yang , Li Jun , An Yaping , Yu Shan
Published: August 2024

Background and aim

Cardiovascular disease (CVD) risk among individuals across different categories of metabolic obesity phenotypes is controversial. The study used body fat percentage (BFP) or body mass index (BMI) to categorize obese status and to investigate the association between metabolic obesity phenotypes and CVD risk in a nationally representative population.

Methods

This cross-sectional study included 49463 adult participants in National Health and Nutrition Examination Survey from 1999 to 2020. Metabolic healthy status was defined by the absence of metabolic syndrome according to the revised National Cholesterol Education Program Adult Treatment Group definition. Obesity was identified by BFP, assessed by dual-energy X-ray absorptiometry scan, and BMI. The primary outcome was CVD prevalence. The multivariable logistic regression model and restricted cubic spline analyses were used to examine the associations between metabolic obesity phenotypes and the risk of CVD.

Results

Among 49463 adult participants, 32.12% were metabolically unhealthy, 34.10% were overweight, 37.94% were obese; and 8.41% had CVD. Compared with metabolic healthy normal weight, metabolic healthy obesity, and metabolic unhealthy normal weight/overweight/obesity were all associated with increased CVD risk with adjusted odds ratios (95% confidence intervals) of 1.45 (1.14–1.85), 2.80(1.53–5.11), 2.55(1.88–3.47), and 2.96(2.18–4.02), respectively. Nonlinear dose-response relationships between BFP and CVD were observed both in metabolically healthy and unhealthy participants (both P for non-linearity<0.0001). When obesity was defined with BMI, there were a similar prevalence of obesity, and similar associations between metabolic obesity phenotypes and CKD risks.

Conclusions

Metabolic healthy and unhealthy obesity were both associated with higher risks of CVD, whether using BFP or BMI to define obese status. It suggests that metabolic obesity phenotype is a risk factor for CVD.
Improving realty management ability based on big data and artificial intelligence decision-making
Authors: Wu Aichun
Published: August 2024

Realty management relies on data from previous successful and failed purchase and utilization outcomes. The cumulative data at different stages are used to improve utilization efficacy. The vital problem is selecting data for analyzing the value incremental sequence and profitable utilization. This article proposes a knowledge-dependent data processing scheme (KDPS) to augment precise data analysis. This scheme operates on two levels. Data selection based on previous stagnant outcomes is performed in the first level. Different data processing is performed in the second level to mend the first level’s flaws. Data processing uses knowledge acquired from the sales process, amenities, and market value. Based on the knowledge determined from successful realty sales and incremental features, further processing for new improvements and existing stagnancy mitigation is recommended. The stagnancy and realty values are used as knowledge for training the data processing system. This ensures definite profitable features meeting the amenity requirements under reduced stagnancy time. The proposed scheme improves the processing rate, stagnancy detection, success rate, and training ratio by 8.2%, 10.25%, 10.28%, and 7%, respectively. It reduces the processing time by 8.56% compared to the existing methods.
OS Therapies to Develop ‘Tunable’ ADCs
Authors:   Sunvalley Communication, LLC, Hofland Peter
Published: August 2024

OS Therapies is advancing a next-generation antibody-drug conjugate (ADC) technology platform, known as tunable ADCs (tADCs), which features tunable, tailored antibody-linker-payload candidates. This platform leverages the company’s proprietary silicone linker technology, enabling the delivery of multiple payloads per linker.
Recuperando la memoria comunitaria del municipio de Nemocón (Colombia) a partir del estudio del cuadro de la Virgen de Checua.
Authors: Gutiérrez Rodríguez Camilo Andrés
Published: August 2024

El presente artículo explora cómo la investigación desde las artes plásticas, aplicando específicamente la metodología basada en artes, al estudio historiográfico del cuadro de la Virgen de Checua, (resguardado hoy en día en el templo parroquial del municipio de Nemocón, Colombia), ha permitido reconocer parte de la historia misma de esta obra, y además, explorar su relación con hechos y momentos históricos de relevancia para el municipio, tales como la fundación misma de la población, hasta batallas de guerras civiles. De igual forma, cómo el uso de esta metodología ha permitido abrir nuevos campos de indagación relacionados con la memoria comunitaria, los álbumes fotográficos familiares, el patrimonio artístico y la historia misma de Nemocón y de la región, gracias a la puesta en diálogo de las narraciones orales de los adultos mayores, los fondos documentales y archivos fotográficos, en pro tanto de reconstruir la historia del óleo de la Virgen, como de la región a la que históricamente ha pertenecido. Esta apertura ha dado espacio a que diferentes áreas del conocimiento, como la antropología, se interesen en eventos y lugares pasados por alto en investigaciones anteriores. Así mismo, este material ha servido como base para la producción de piezas plásticas, y a partir de dichos resultados de se ha logrado acercar tanto a la población en general, como a las autoridades religiosas, al patrimonio cultural e histórico, logrando de esta manera una mayor comprensión sobre la importancia de los bienes patrimoniales materiales e inmateriales, y de sus propias historias, tanto personales como familiares.
On being a scholar/activist: Personal history and acquired wisdom
Authors: Apple Michael W.
Published: August 2024

Requests to publicly think about what one has learned over time are always interesting to me. They require that authors reflect back on a trajectory that may not be totally clear even to the writers themselves. They ask writers to construct an historical narrative that is simultaneously both personal and intellectual/political. In this “acquired wisdom” essay, I want to engage with this combined task, to reflect on some of the political/intellectual/educational history of the development of my work over time, on some of the most important things I have learned, and on the situations and processes that made this more likely.  At the same time, I want to situate this development in some of the more personal groundings that might explain how and why the work I’ve done came about.
Let me begin with some general points that bear on my later comments about my grounding in politically engaged educational efforts. There are two fundamental motivations behind such critical work. The first is understanding the complex dynamics of exploitation, domination, and subordination that all too often structure our societies and their constitutive relations inside and outside of education. Yet, while understanding is absolutely crucial, it is not sufficient. Emerging out of such understandings is a commitment to interruption. Both understanding and interruption have their basis in a set of ethical and political commitments that are simultaneously collective and personal (Bourdieu, 2003). And both are crucial to me.
Historic Kyiv Polish. Between North and South Borderlands
Authors: Klimek-Grądzka Jolanta
Published: August 2024

The article discusses the specific, both sociologically and geographically determined Polish language of Kyiv, perceived by the author as a “territorial variation of the Polish literary language existing within the circle of Polish and Ruthenian intelligentsiain Kyiv in the 17th century around the Kyiv-Mohyla Academy, represented by the prints of the typography of the Kyiv-Pechersk Lavra.” The key was the application of linguistic criteria (phonetic, inflectional and syntactic ones) and answering the question of which variation of the borderland Polish we are dealing with: the northern or the southern one. However, a review of linguistic features shows that the Kyiv Polish language situates itself between the north and south borderlands. At every level of the language, features characteristic of both the southern and northern borderlands are noticeable, with the majority accounting for features common to both regions.
Nazwy własne w literaturze dziecięcej Rogera Hargreavesa w tłumaczeniu Marcina Wróbla
Authors: Łuc Izabela
Published: August 2024

The subject of the analysis presented in the article were personal names and toponyms derived from 42 stories by Roger Hargreaves addressed to children aged 4–6. The description of proper names in the British writer’s works is based on theassumption that the translator fully understood and faithfully reflected the author’s intentions, taking into account the functionality of the cycle of stories and the age of the recipient, and that his goal was to faithfully translate the senses contained in the semantics/sound of the created onyms. The study aimed to capture the mechanisms of creating proper names and the ways of introducing onyms into the text. The article also describes an onymic strategy consisting of a syntactic and semantic juxtaposition of anthroponyms with toponyms which serves to complete the characterisation of the heroes and the construction of the literary world. The names extracted from Hargreaves’s works were considered in terms of their textual and semiotic structures, in both the motivational and pragmatic dimensions. A semanticpragmatic analysis of the names showed that the onyms invented by the author/translator were created as series. Within the creative models used by him, the following stand out due to their frequency: names derived using suffixes, names created with the use of an appellative used specifically for naming people – pan [mister], formations composed with the lexeme mały [small] and items created by means of onymisation.
Coalgebraic methods for Ramsey degrees of unary algebras
Authors: Mašulović Dragan
Published: August 2024

In this paper, we prove the existence of small and big Ramsey degrees of classes of finite unary algebras in an arbitrary (not necessarily finite) algebraic language Ω. Our results generalize some Ramsey-type results of M. Sokić concerning finite unary algebras over finite languages. To do so, we develop a completely new strategy that relies on the fact that right adjoints preserve the Ramsey property. We then treat unary algebras as Eilenberg-Moore coalgebras for a functor with comultiplication, and using pre-adjunctions transport the Ramsey properties, we are interested in from the category of finite or countably infinite chains of order type ω. Moreover, we show that finite objects have finite big Ramsey degrees in the corresponding cofree structures over countably many generators.
Existence results for a fourth order problem with functional perturbed clamped beam boundary conditions
Authors: Cabada Alberto , Jebari Rochdi , López-Somoza Lucía
Published: August 2024

In this paper, we study the existence of positive solutions for a fourth order boundary value problem coupled to functional perturbed clamped beam boundary conditions. Our main ingredient is the classical fixed point index. The problem investigated is an extension of other problems studied in previous papers by covering very general nonlocal perturbed conditions on the boundary.
Induced mappings on the hyperspace of totally disconnected sets
Authors: Anaya José G. , Hernández-Castañeda Martha , Maya David
Published: August 2024

The symbol TD(X) denotes the hyperspace of all nonempty totally disconnected compact subsets of a Hausdorff space X. This hyperspace is endowed with the Vietoris topology. For a mapping between Hausdorff spaces f : X → Y, define the induced mapping TD(f) : TD(X) → TD(Y) by TD(f)(A) = f(A) (the image of A under f). In the current paper, we study the relationships between the condition f belongs to a class of mappings between Hausdorff spaces 𝕄 and the condition TD(f) belongs to 𝕄.
Leitura da literatura infantil como possibilidade de multiletramento
Authors: Brocchetto Ramos Flávia , Senaide Petry Panozzo Neiva
Published: August 2024

O projeto de pesquisa “Educação, linguagem e práticas leitoras II” abrange a leitura de diferentes produtos culturais contemporâneos destinados à infância. Trata-se de um desdobramento de questões evidenciadas em virtude dos processos de hibridização de linguagem. Entre as ações desta pesquisa está a análise de livros de literatura infantil, visando à identificação e à caracterização de apelos verbo-visuais empregados na sua constituição e que mobilizam o leitor. Este artigo investiga a constituição da uma narrativa verbo-visual, por meio de um estudo descritivo-analítico realizado em pesquisa acadêmica, para identificar possíveis processos de significação a serem concretizados pelo leitor. A análise considera as ilustrações e as palavras como indícios para a produção de sentido e como possibilidade de interpretação. Os sentidos da narrativa emergem do jogo entre linguagens que se integram, e a obra em estudo, como narrativa híbrida, revela uma proposta de literatura de cunho emancipatório.
Material didático para educação tecnológica de professores de inglês: uma experiência no âmbito do programa ‘novos talentos’
Authors: Salles El Kadri Michele , Gamero Raquel , Gimenez Telma
Published: August 2024

Este trabalho objetiva apresentar, descrever e analisar dois módulos do material didático desenvolvido para a formação continuada de professores de inglês, intitulado “Connecting ide@s: tools for teaching English in a contemporary society”. O material foi produzido com o propósito de subsidiar oportunidades para o desenvolvimento de professores de língua inglesa e também o ensino dessa língua por meio de gêneros digitais. A análise está embasada nos critérios estabelecidos pelas diretrizes curriculares nacionais para a formação de professores (BRASIL, 2002), e nos parâmetros estabelecidos pelo TESOL Technological Standard Framework (HEALEY et al., 2009). Os resultados preliminares apontam que as unidades atingem parcialmente os objetivos estabelecidos pelos dois parâmetros. A reformulação do material deverá ainda levar em conta os resultados efetivos alcançados a partir da análise das produções didáticas dos professores atendentes do curso.
A dinâmica da transferência interlinguística de padrões de VOT em crianças multilíngues
Authors: Tessmann Bandeira Marta , Cristina Zimmer Márcia
Published: August 2024

Este artigo apresenta os resultados de uma investigação sobre as diferenças relativas aos padrões de VOT em plosivas surdas do inglês produzidas por crianças monolíngues e multilíngues, aprendizes de inglês. Também apresenta uma análise da dinâmica da transferência dos padrões de VOT das plosivas /p/, /t/ e /k/ nas três línguas (pomerano, português brasileiro e inglês)  faladas pelas crianças multilíngues, a partir da noção de deriva gestual (SANCIER; FOWLER, 1997; FOWLER et al., 2008).
A reescrita no contratempo: tempo de reconhecer a instrução, tempo de compreender a ação, tempo de apropriar-se da interlocução
Authors: Silva Silvana , Flores Valdir
Published: August 2024

Este artigo apresenta uma discussão sobre a instrução em ambiente técnico e educacional. Em nossa breve revisão teórica, observamos que instrução tem definições diferentes para os Estudos Cognitivos, para a Linguística do Texto e para Projetos de Escrita Criativa. O principal objetivo é problematizar a noção de instrução em uma situação de escrita autoral. Para tal objetivo, apresentamos a fundamentação teórica da Linguística da Enunciação (BENVENISTE, 1988, 1989), em especial as noções de sujeito e correlatas, tempo e processo de enunciação. Analisamos algumas instruções em uma situação de orientação de artigo de conclusão de curso de Especialização em Linguagem e concluímos que a instrução bem sucedida é aquela que permite ao aluno novas interlocuções.
Os efeitos de um treinamento de percepção na aquisição de pré-proparoxítonas inglesas por brasileiros
Authors: Brawerman Albini Andressa , Cristina Kluge Denise , Hercília Pescatori Silva Adelaide
Published: August 2024

Este trabalho investiga os efeitos de um treinamento de percepção na aquisição do padrão acentual pré-proparoxítono da língua inglesa por falantes brasileiros. Parte-se da hipótese de que falantes de português brasileiro armazenem poucos exemplos de palavras pré-proparoxítonas pelo fato de ser um padrão de acentuação raro em sua língua materna. Assim, esse padrão seria pouco frequente ou produtivo para eles. O treinamento perceptual consistiu em tarefas de identificação do acento com feedback imediato ministradas durante cinco sessões. Os resultados obtidos confirmam que o treinamento possibilitou uma melhora significativa na percepção e  produção de pré-proparoxítonas. Ainda, os efeitos da produção são generalizados para novas palavras e retidos por um período de dois meses após o término do treinamento. Acredita-se que, a partir do uso frequente do padrão pré-proparoxítono, o treinamento teria proporcionado a criação dessa categoria pelos participantes desta pesquisa.
Produção textual na universidade
Authors: Escandiel de Souza Antonio
Published: August 2024

MOTTA-ROTH, Désirée; HENDGES, Graciela H. Produção textual na universidade. São Paulo: Parábola Editorial, 2010.
M[e]nino ou m[i]nino? Bol[o] ou bol[u]? O tratamento das vogais do português brasileiro (LE) por manuais voltados a aprendizes argentinos
Authors: Kickhöfel Alves Ubiratã , Machry da Silva Susieli
Published: August 2024

Neste artigo, analisamos o tratamento dispensado ao componente fonético-fonológico em duas séries de materiais didáticos voltadas ao ensino do português brasileiro (LE) para aprendizes argentinos. Concentramo-nos, especificamente, no ensino do sistema vocálico. A análise dos materiais revela que, ainda que as oposições em posição tônica sejam abordadas pelas duas séries, há pouca sistematicidade no que diz respeito à posição átona. As pós-tônicas não-finais são tratadas por ambas as coleções, ao passo que a variação da pré-tônica é marginalmente abordada. Os resultados chamam a atenção para a necessidade de materiais que abordem a variação do sistema vocálico átono, bem como ressaltam o papel fundamental da formação teórica do profissional de ensino para uso eficiente desses materiais.
Que pesquisa? Qual ensino?
Authors: Ubirajara Sobral Adail
Published: August 2024

Este ensaio, que nasceu da mesa-redonda “A pesquisa serve de fundamento para o ensino de língua(s)?”, de que o autor participou no VI SENALE (2010), bem como de discussões nos simpósios de doutorado com alunos da UCPEL e com os professores Hilário Bohn e Vilson Leffa, se propõe a apresentar questionamentos acerca das possíveis relações entre pesquisa e ensino de língua(s) a partir da questão fundadora da referida mesa-redonda. Para isso, discute relações entre pesquisa e ensino de língua(s) a partir de questões como “pesquisa pura” e “pesquisa aplicada”, defendendo, para além de um “ensino pragmático”, um ensino cientificamente sensível e, para além da pesquisa “pura” ou “aplicada”, uma pesquisa cientificamente rigorosa, mas socialmente sensível, com ênfase na questão da responsabilidade social do pesquisador e do professor de línguas/linguagens.
O ato de ensino: da transmissão de saberes à constituição de sujeitos e de sentidos na formação docente
Authors: Terezinha da Rosa Marluza
Published: August 2024

O objetivo deste estudo é o de investigar as representações acerca do professor e de seu lugar, como sujeito suposto saber, constitutivas do imaginário de pesquisadores em formação. Tal propósito se justifica pelo fato de a pesquisa universitária no Brasil estar, de um modo ou de outro, vinculada à preparação para a atuação docente. Tomamos como suporte teórico-conceitual os estudos discursivos, desenvolvidos em diálogo com o viés psicanalítico lacaniano. Com base na discussão proposta em torno dos recortes analisados, os quais foram extraídos de entrevistas semidiretivas, entendemos que a relação de saber na qual se investem professor e aluno interfere na constituição identitária destes, movendo-os e afetando-os, enquanto sujeitos de desejo.
“Como Obama Pode Pressionar para Obter Paz”: uma Postura Favorável e Avaliação Atitudinal Positiva
Authors: Aparecida Florêncio Jane , Regina Scotta-Cabral Sara
Published: August 2024

A linguagem é usada para cumprir alguma tarefa ao mesmo tempo em que é usada para constituir e expressar a subjetividade do escritor. Numa tentativa de identificar as posições valorativas e avaliações adotadas pelos escritores, em um artigo de opinião, com relação à interferência dos E.U.A. na guerra de Gaza, uma análise específica foi conduzida com base na Teoria da Avaliatividade (MARTIN; WHITE, 2005) e na perspectiva de Coesão Textual(HALLIDAY; HASAN, 1976; 1985; HALLIDAY; MATTHIESSEN, 2004). Os resultados mostraram que os escritores tomam uma posição favorável quanto à interferência estadunidense e, simultaneamente, aceitam posições alternativas. Além disso, os escritores criam um grupo de palavras do mesmo campo geral que coesamente conecta o texto, e estas recebem avaliações atitudinais positivas, principalmente em termos de comportamento.
A Ferramenta VoiceThread em uma abordagem híbrida: o desenvolvimento da produção oral de aprendizes de inglês como L2
Authors: Azevedo de Sousa Lorena , Weissheimer Janaina
Published: August 2024

VoiceThread (VT) é uma ferramenta assíncrona que permite a criação de apresentações orais, possibilitando que grupos de pessoas contribuam com comentários utilizando a voz. Neste contexto, o presente estudo visa a verificar de que forma a prática com o VT, em uma abordagem híbrida, impacta a produção oral dos aprendizes. A fim de responder a essa questão, aprendizes de inglês como L2 foram divididos em grupo experimental e grupo de controle. O grupo experimental foi exposto a atividades com o VT e, por meio de um pré e um pós-teste, verificamos se essa prática influenciaria sua produção oral. Esses resultados foram comparados aos escores do pré e do pós-teste do grupo controle, que não foi exposto ao VT. Por fim, as impressões dos aprendizes foram analisadas por meio de questionários. Os resultados apontam que há um impacto positivo da ferramenta VT sobre a produção oral dos aprendizes; e revelam uma reação positiva deles em relação à experiência híbrida com esta ferramenta.