bluuebunny/crossref_metadata_2025 huggingface dataset:
Factores biopsicosociales y calidad de vida en fibromialgia desde la terapia ocupacional. Un estudio cualitativo.
Authors: Carro Castiñeira Tamara , Vila Paz Alba , Santos-del-Riego Sergio
Published: November 2023

Resumen Introducción La Fibromialgia es una enfermedad crónica caracterizada por mialgias localizadas en el aparato locomotor que ocasionan un deterioro funcional. Su tratamiento se basa en el uso de fármacos combinados con intervenciones de diversas modalidades terapéuticas, entre ellas, las propias de la Terapia Ocupacional (TO). Los síntomas de la enfermedad afectan a todas las áreas ocupacionales, evidenciándose en el desempeño diario. Objetivos Los objetivos del presente estudio fueron identificar las ocupaciones con mayor grado de afectación en las personas con Fibromialgia; explorar el impacto de los factores biopsicosociales en las ocupaciones de las personas diagnosticadas de Fibromialgia; conceptualizar de qué manera influye la calidad de la red de apoyo y la situación económica de las personas diagnosticadas de Fibromialgia en la autopercepción de los síntomas de la enfermedad y determinar si existe una relación entre los sucesos negativos en la infancia y la Fibromialgia. Métodos Se empleó una metodología cualitativa desde el enfoque fenomenológico. La recolección de información se realizó mediante encuestas ad hoc administradas a las 8 voluntarias. Posteriormente, se analizaron los resultados a través del programa Atlas. TI® y se transcribieron con el programa Microsoft Word®. Resultados Las personas entrevistadas presentaron limitaciones en las siguientes áreas ocupacionales: actividades instrumentales de la vida diaria (AIVD), ocio y tiempo libre, participación social, descanso y sueño, actividad sexual y trabajo. Se estableció una relación entre la calidad de la red de apoyo y la situación económica con la percepción de los síntomas. También se exploró la relación entre los sucesos negativos en la infancia y la Fibromialgia. Conclusiones Los factores biopsicosociales tienen una influencia crucial en la calidad de vida, pudiendo actuar como factores de protección o de riesgo ante la intensidad de los síntomas.
Whiteness and the dimensions of the unsaid in/of occupational therapy
Authors: Porto Roberta de Mendonça , Silva Carla Regina
Published: November 2023

Abstract The reflections presented in this essay are part of the investigation path of the research 'Racism, Whiteness and the production of knowledge of/in Occupational Therapy', a composition of different fluxes, experiences, constructions and encounters, mobilized by the technical, ethical, aesthetic and political contribution to the debate on Racism, putting into analysis the Whiteness of/in Occupational Therapy. Under the clues of the cartographic intervention research, this work had as main material, analyzes that emerged from the BranquiTOde study group, organized to discuss the proposed theme. Inspired by the “Critical Studies of Whiteness” we challenge ourselves to look at our own whiteness and our own racism as white women, researchers, and occupational therapists, and from this inflection several debates were made about racism and whiteness that engender the relations of/in the field. By deepening the understanding processes on how hegemonic systems produce and reproduce racist colonial logics, based on the idea of racial supremacy of white people, we propose some reflections on the ways in which exclusions and inequalities directly interfere in the human activities of people and collectives of subjects. that we have the privilege of accompanying in the most different fields, practices with Occupational Therapy. Furthermore, we understand that producing questions about racial inequalities in the University/Occupational Therapy, means questioning the epistemologies of the fields of knowledge and opening cracks to other cosmovisions, other perspectives of the world, of life, of the university, is a bet on the invention of others. ways of producing practices, knowledge, and possible worlds.
SALÁRIO EMOCIONAL COMO FERRAMENTA DE GESTÃO: IMPORTÂNCIA ATRIBUÍDA POR PROFISSIONAIS DE ENFERMAGEM
Authors: Pires Vladia Pinheiro de Sousa , Perroca Marcia Galan
Published: November 2023

RESUMO: Objetivo: identificar a importância atribuída por profissionais de enfermagem aos componentes propostos do salário emocional; e verificar a associação com variáveis sociodemográficos e laborais dos participantes. Método: estudo exploratório com 172 profissionais de um hospital oncológico do estado de São Paulo - Brasil, realizado em 2021. Construiu-se e validou-se um questionário contendo 40 componentes do salário emocional. Para a análise, utilizaram-se medidas de tendência central e testes não paramétricos. Resultados: enfermeiros destacaram a oportunidade de progressão na carreira e sentir-se respeitado - 3,8 (0,4); e os técnicos/auxiliares, sentir-se respeitado pelos colegas, atuação colaborativa e importância social do trabalho - todos com 3,7(0,5). Houve associação dos escores da escala com escolaridade (p ≤0,05). Conclusão: a maioria dos componentes do salário emocional é valorizada, principalmente aqueles relacionados às relações profissionais e condições de trabalho. Os achados podem direcionar políticas de pessoal nas organizações, favorecendo a satisfação laboral, a qualidade assistencial e os resultados organizacionais.
RESTRICTED MOVEMENT OF THE SPINE: AN ANALYSIS OF THE KNOWLEDGE OF NURSING PROFESSIONALS
Authors: Brigolini Gabriela , Ciconet Rosane Mortari
Published: November 2023

ABSTRACT Objective: To analyze nursing professionals’ knowledge about restricting spinal movement in trauma victims and describe their decision-making. Method: An exploratory, descriptive, qualitative-quantitative study. A semi-structured interview was conducted with 27 nursing professionals from hospital and pre-hospital emergency services in São Leopoldo, Brazil, in March 2022. The data was analyzed using descriptive statistics and content analysis. Results: 48% of the professionals knew the current recommendations; most worked in pre-hospital care. Cervicalgia/lumbago was the predominant indication. In the category “decision making and the transition of care”, a lack of standardization in in-hospital conduct was identified, emphasizing the importance of sequence in care and trust between professionals. Final considerations: It was found that in-hospital teams had little knowledge of the current evidence, a lack of standardization in procedures, and difficulties in the transition of care between services.
EMOTIONAL SALARY AS A MANAGEMENT TOOL: IMPORTANCE ATTRIBUTED BY NURSING PROFESSIONALS
Authors: Pires Vladia Pinheiro de Sousa , Perroca Marcia Galan
Published: November 2023

ABSTRACT Objective: to identify the importance attributed by nursing professionals to the proposed components of emotional salary, and to verify the association with the participants’ sociodemographic and work-related variables. Method: exploratory study with 172 professionals from an oncology hospital in the state of São Paulo - Brazil, carried out in 2021. A questionnaire containing 40 components of emotional salary was constructed and validated. Measures of central tendency and non-parametric tests were used for the analysis. Results: nurses highlighted the opportunity for career progression and feeling respected - 3.8 (0.4); and technicians/auxiliaries, feeling respected by colleagues, collaborative action, and the social importance of work - all with 3.7 (0.5). There was an association between the scale scores and schooling (p ≤0.05). Conclusion: Most of the components of emotional salary are valued, especially those related to professional relationships and working conditions. The findings can guide personnel policies in organizations, favoring job satisfaction, quality of care and organizational results.
PERCEPCIONES DEL PERSONAL DE ENFERMERÍA DE LAS UNIDADES BÁSICAS DE SALUD SOBRE SU ACTUACIÓN EN CASOS DE DEPRESIÓN
Authors: Souza Jéssica Kayane de , Mendes Daniela do Carmo Oliveira , Silva Grasiele Cristina Lucietto da , Vedana Kelly Graziani Giacchero , Scorsolini-Comin Fabio , Fiorati Regina Célia , Ferreira Luana Vieira Coelho
Published: November 2023

RESUMEN Objetivo: conocer cómo abordan los enfermeros los casos de depresión en los centros de atención básica de salud. Método: Investigación cualitativa, realizada en 2020, mediante entrevista abierta a 15 enfermeros que trabajan en unidades básicas de salud de un municipio de la región Centro-Oeste de Brasil. Las entrevistas se sometieron a un análisis de contenido. Resultados: Quedó claro que los enfermeros tienen dificultades multifactoriales para tratar los casos de depresión. Sin embargo, señalan estrategias que indican vías para cualificar su práctica clínica, como la importancia de la formación profesional y el refuerzo del trabajo en equipo, para que estén preparadas y cualificadas para ofrecer cuidados de enfermería eficaces y humanizados a las personas con depresión. Conclusión: Incluso ante los retos surgidos, la continuidad de las acciones de enfermería dirigidas a los pacientes con depresión y otros trastornos mentales es fundamental, especialmente en contextos que cuentan con una red de atención a la salud mental debilitada.
Teologia-política e pandemia Sars-Cov-2/Covid-19: questões à Saúde Coletiva
Authors: Leão Luís Henrique da Costa
Published: November 2023

Resumo Este ensaio teórico apresenta, em linhas gerais, o campo da teologia-política enquanto importante área da filosofia política, demonstra sua relevância no atual cenário sociopolítico brasileiro e problematiza suas possíveis intersecções com o campo da Saúde Coletiva. Na primeira parte, busca-se explorar o pensamento teológico-político de autores centrais dessa área, como Santo Agostinho, Giorgio Agamben, Karl Marx, Enrique Dussel e Boaventura de Souza Santos. À luz desses autores, na segunda parte do artigo, descreve-se a emergência de teologias-políticas no cenário político e na dinâmica sociocultural brasileira, manifestas entre grupos evangélicos durante a pandemia de covid-19. Esse cenário da pandemia revelou muitas contradições da sociedade brasileira e evidenciou controvérsias entre duas linhagens de teologias-políticas evangélicas divergentes: as conservadoras/antidemocráticas e as progressistas. A reemergência dessas teologias políticas tem efeitos relevantes no que tange às respostas de grupos sociais e ações do poder frente aos problemas de saúde pública, que merecem maior atenção do campo da Saúde Coletiva. Elas influenciam as esferas do poder e a dinâmica sociocultural no que se relaciona à saúde-doença-cuidado, contribuindo com medidas de proteção coletiva e/ou estimulando posturas de risco, negligências e negacionismos. Conclui-se problematizando contribuições epistemológicas para uma renovada produção do conhecimento-ação na interface da teologia política com a Saúde Coletiva.
Desenvolvimento de membrana cerâmica de microfiltração a partir de resíduo de casca de arroz e caulim e aplicação como pré-tratamento de efluente da indústria de papel
Authors: Guimarães Érissa Amábile Calliari Machado , Levandoski William Mateus Kubiaki , Vargas Gean Delise Leal Pasquale , Korf Eduardo Pavan , Dervanoski Adriana
Published: November 2023

RESUMO A indústria de processamento de papel está entre as três maiores produtoras de águas residuais de significativa contaminação ambiental. Com o objetivo de minimizar os impactos nos corpos d’água e se adequar aos padrões exigidos pela legislação, são necessárias soluções avançadas de tratamento. Neste trabalho, uma membrana cerâmica de microfiltração foi desenvolvida, tendo como base 60% da composição correspondente ao resíduo de cinza de casca de arroz e 40% de Caulim, para ser aplicada como pré-tratamento do efluente real da indústria de papel. A membrana foi obtida por compactação uniaxial a 27 MPa em uma prensa elétrica, com posterior sinterização em mufla a 1.200°C por 1 hora. Os materiais foram caracterizados por análises químicas e físicas. A membrana apresentou porosidade aparente de 34,59%, densidade de 1,30 g/cm³, retração linear de diâmetro e espessura de 1,7 e 2,5%, respectivamente, perda ao fogo de 9,3% e boa estabilidade química em ácido e base. A permeabilidade hidráulica correspondeu a 11,3 × 10-3 m3/m2 s MPa-1, com diâmetro hidráulico de poros de 2,29 μm e tamanho médio de poros de 1,727 μm. A caracterização do efluente bruto revelou altos teores de demanda química de oxigênio (1.125,4 mg•L-1), turbidez (1.300 UNT) e cor (253,8 UC). O estudo de filtração indicou resultados satisfatórios de eficiência da membrana, com remoção de turbidez (99,3%), demanda química de oxigênio (95,7%), cor (83,0%), compostos fenólicos (82,1%) e sólidos (85,1 a 90%). O uso da cinza de casca de arroz desempenhou a função de agente formador de poros e adsorvente de compostos fenólicos, representando promissora alternativa para a incorporação do resíduo ao ciclo produtivo.
Avaliação do ciclo de vida de um sistema integrado UASB/biofiltro anaeróbio com wetlands construídos e filtro misto com suporte reativo no tratamento de efluentes urbanos
Authors: Sosa Eduardo Ezequiel , Colares Gustavo Stolzenberg , Conrad Igor Ricardo , Kroth Gabriela Caroline , Rodriguez Adriane Lawisch , Mesacasa Letícia , Fochi Deison Antonio Taufer , Teixeira Daniel Brinckmann , Oliveira Fábio , Machado Ênio Leandro
Published: November 2023

RESUMO Nesta pesquisa, foi estudado o impacto ambiental do sistema UASB/Biofiltro Anaeróbio (reator anaeróbio de manta de lodo — UASB/BFA) + wetland construído do tipo floating (WCF) + wetland construído de fluxo vertical-célula de combustível microbiana (WCFV-CCM) + filtro misto com suporte reativo (FLR), aplicado para remediação em escala piloto de efluentes urbanos em um campus universitário. Foram feitos cenários de propostas de mudanças das configurações da estação de tratamento de efluente (ETE) (Cenários 2 e 3). O sistema do Cenário 1 foi operado em pulsos, com aplicação de 2,9 m3 de efluente de campus universitário semanalmente. A energia necessária para o bombeamento na unidade em escala piloto (Cenário 1) e para a potencial aplicação com fluxo por escoamento (Cenário 2) foi inventariada, considerando materiais de construção e processamento, especialmente com o controle de carga poluente nos efluentes líquidos e atmosféricos. O software SimaPro 8.0.4 foi utilizado, tendo como unidade funcional 2,9 m3 semana-1 de efluente e fluxo de referência de 20 anos. Os resultados demonstraram que os materiais da construção do sistema contribuíram com 84,8% (em pontuação única — Pt), e a operação do sistema do Cenário 2 contribuiu com 15,2%, sem o uso de energia elétrica para o bombeamento. Já o Cenário 3 mostrou que a substituição dos tanques de fibra de vidro por tanques de fibrocimento poderia ajudar a reduzir os impactos ambientais na fase de construção do sistema em até 58,6% em termos de uso de energia e até 80% nas emissões de poluentes carcinogênicos.
Biorreator com membranas de leito móvel tratando efluente de baixa carga de indústria de produção de papel: análise de desempenho e da colmatação das membranas
Authors: Pedroso Carlos Raphael , Vidal Carlos Magno , Belli Tiago José , Campos Sandro Xavier de , Silva Cleber Pinto da
Published: November 2023

RESUMO O processo de biorreator com membranas tem se consolidado nos últimos anos como uma alternativa aos métodos tradicionais para o tratamento de efluentes da indústria de produção de papel. Recentemente, a introdução de material suporte nesses reatores tem contribuído para a melhoria de seu desempenho, tendo em vista a maior atividade biológica que se verifica em decorrência do desenvolvimento de biofilme. Assim, a presença da biomassa aderida confere uma capacidade adicional ao biorreator com membranas em suportar choques de cargas, bem como pode contribuir para a biodegradação de compostos potencialmente tóxicos e recalcitrantes como derivados da lignina. Desse modo, o presente trabalho teve como objetivo avaliar o desempenho de um biorreator à membrana de leito móvel operado em batelada sequencial e aplicado ao tratamento de efluente real de baixa carga oriundo da produção de papel. O reator foi avaliado quanto ao seu desempenho na remoção de demanda química de oxigênio solúvel, fenol total, cor verdadeira, compostos aromáticos (UV254nm) e lignínicos (UV280nm). Paralelamente, o reator foi avaliado quanto ao processo de colmatação das membranas, por meio do monitoramento da pressão transmembrana, da concentração de substâncias poliméricas extracelulares e produtos microbianos solúveis). Nas condições testadas, o biorreator à membrana de leito móvel operado em batelada sequencial atingiu eficiência média de remoção de 89% para demanda química de oxigênio solúvel, 39% para UV254nm, 38% para UV280nm, 57% para cor verdadeira e 73% para fenóis totais. Em relação à colmatação das membranas, as variáveis UV254nm, UV280nm e fenóis totais correlacionaram-se diretamente com o aumento da pressão transmembrana (PTM).
The technical report of the CAPES’ technical production working group: a critical view
Authors: Mamede Walner
Published: November 2023

Abstract This paper attempted to perform an analysis of the technical report for assessment of technical and technological products born from working group by Capes, in 2019. We aimed evaluate its instrumental adequacy. Our analysis applaied the literature about characteristics that must necessarily be present in technical or technological reports to support our conclusions. As a result, we found evidence that the Capes' technical report about assessment technical and technological products doesn't suit the necessary characteristics to be established as applicable assessment instrument over other technical reports.
LITERACIA CIENTÍFICA: UM OLHAR SOBRE AS SUAS DIFERENTES INTERPRETAÇÕES
Authors: Coppi Marcelo , Fialho Isabel , Cid Marília
Published: November 2023

O estudo teve por objetivo realizar uma abordagem crítica e histórica a respeito do conceito de literacia científica, da definição das palavras que compõem o termo, das suas traduções e da existência de instrumentos desenvolvidos para avaliá-la. Observou-se que um dos motivos para as diversas perspetivas conceituais é o significado da palavra literate, que, no idioma inglês, pode significar ser detentor do conhecimento e, também, ser capaz de ler e escrever. Outra razão é a tradução da palavra literacy, a qual pode originar, no idioma português, as palavras alfabetização, literacia e letramento, assumindo diferentes significados de acordo com a sua interpretação. O conceito de literacia científica também se revela como uma das causas geradoras de imprecisões. O facto de haver uma pluralidade de conceitos faz com que, muitas vezes, a literacia científica seja confundida e limitada à compreensão da ciência. Por fim, a avaliação da literacia científica configura-se como fonte de debate entre os pesquisadores da área, uma vez que existem poucos instrumentos disponíveis na literatura, a maioria deles avalia aspetos e dimensões isolados da literacia científica e a minoria demonstra os processos de validade na sua elaboração. Em síntese, o estudo evidencia as grandes polémicas na literatura que concernem a literacia científica, apresenta as principais razões de tais controvérsias e demonstra que, a despeito destes aspetos, a literacia científica é objeto de pesquisas de âmbito internacional e apresenta-se, de uma forma ampla, como o principal objetivo do ensino de ciências.
Determining parameters of peat soil for finite-element analysis using the Cam Clay model
Authors: Hayashi Hirochika , Yamazoe Nobutaka
Published: November 2023

A practical procedure for determining soil parameters when analysing the deformation of peat by finite-element analysis (FEA) using the Cam Clay model is presented. FEA has not been frequently used to predict the deformation of peat soil, even though it can be a powerful prediction tool. The main reason for this is that a practical method for determining parameters has not been established. In this paper, the remarkable correlation between the soil parameters required for FEA using the Cam Clay model and the natural water content (wn) and ignition loss (Li) of peat and organic clay is presented. Then, based on this correlation, a flow chart for determining the soil parameters of peat and organic clay is proposed. Using this chart, it is possible to determine soil parameters directly from triaxial compression, oedometer and other detailed tests or to estimate them from wn, Li and other physical indexes. A trial embankment on peat soil in Hokkaido, Japan, was also created. FEA was performed on the trial embankment using the proposed procedure for determining the soil parameters. The results of the FEA corresponded to the measured settlement behaviour in the trial embankment with an accuracy in the range −4% to +8%. The FEA results also modelled the measured behaviour of pore water pressure and lateral and vertical displacements in the trial embankment very well.
Kestävyyskoulutusta eri kohderyhmille: Kokemuksia POLKU 2.0 -hankkeesta
Authors: Vallius Elisa
Published: November 2023

POLKU 2.0 – Jatkuvan oppimisen Polkukartta kestävään bio- ja kiertotalouteen - hankkeen tavoitteena oli edistää kestävyysosaamista Keski-Suomessa. Kestävyysosaamisen vahvistamista pyrittiin tekemään erityisesti koulutustoiminnan kautta ja neljän suuren koulutusorganisaation (JYU, Jamk, Gradia ja Poke) mukanaolo vahvisti tavoitteiden saavuttamista. Hankkeessa koulutustoiminnan suunnittelu tehtiin eri kestävyysteemojen parissa työskentelevissä tiimeissä, joissa oli edustusta eri aloilta ja eri koulutusorganisaatioista. Koska suunnitteluun osallistuvilla henkilöillä oli kokemusta eri kohderyhmistä ja pedagogisesti erilaisista lähestymistavoista, voitiin yhteistyössä tuottaa monipuolisia ja kohderyhmäkeskeisesti suunniteltuja koulutuksia. Tämä vähensi huomattavasti riskiä tehdä kohderyhmille sopimattomia ratkaisuja ja mahdollisti uudenlaisten lähestymistapojen luomisen.
POLKU 2.0 -hankkeen viestinnän yhteenveto
Authors: Jyrkkänen Helmi , Nikkanen Meri
Published: November 2023

Tässä yhteenvedossa kuvaillaan POLKU 2.0 -hankkeen viestintätoimenpiteitä, joilla pyrittiin herättämään hankkeen kohderyhmien kiinnostus osallistua Polkukartta-koulutuksiin ja lisäämään tietoisuutta kestävyysteemoista. Hankkeen varsinaista kohderyhmää olivat keskisuomalaiset yrittäjät, työntekijät, opiskelijat ja työttömät työnhakijat, sekä keskisuomalaiset opinto- ja uraohjaajat. Yrityskohderyhmän osalta hankkeessa pyrittiin saamaan 10–20 % osallistuvista yrityksistä mukaan Saarijärven–Viitasaaren seudulta. Hankkeessa tehtiin aktiivista ja monipuolista viestintää moninaisten kohderyhmien tavoittamiseksi koko Keski-Suomessa. Tätä varten budjetoitiin jo hakemusvaiheessa ostopalveluvaroja tiedotus- ja markkinointikustannuksiin, kuten sosiaalisen median markkinointiin, mainontaan ja informaatiovideoon sekä hankkeen verkkosivujen ja visuaalisen ilmeen luomiseen.
USE OF LOW-FREQUENCY SEISMIC PROBING METHOD FOR DETERMINATION OF WELL LOCATION COORDINATES FOR DRILLING
Authors: Syuraeva K.V. , Podyachev A.A.
Published: November 2023

A wide range of studies, including structural and tectonic, lithological and facies, geochemical, hydrogeological, and geophysical methods, are carried out during the development of fields at the regional stage of geological exploration. These studies are aimed at solving key problems, such as identifying lithological and stratigraphic complexes, determining the main stages of geotectonic development, and identifying promising oil and gas complexes.However, despite the extensive studies performed, they do not always provide a final confirmation of the presence or absence of oil deposits. In recent years, in order to more accurately determine the location of oil fields, the method of low-frequency passive seismic sensing (LPDS) has attracted attention.This article discusses two hypotheses that explain the causes of anomalies in the spectrum of microseismic signals over oil and gas reservoirs. The first hypothesis assumes that during harmonic seismic excitation, the deposit goes into a state of «turbulent chaos», leading to a change in the characteristics of the seismic signal. The second hypothesis states that a change in the velocity of propagation of seismic waves in the porous environment of the deposit also causes anomalies in the signal spectrum.Experimental data support both hypotheses, and represent anomalies in the spectrum of microseismic signals in the frequency range of 2-5 Hz. Understanding these anomalies is essential for improving oil and gas discovery and evaluation techniques, contributing to more efficient development of oil and gas resources and improving accuracy of well coordinates
OPTIMIZATION IN THE RECONSTRUCTION OF THE RESERVOIR PRESSURE MAINTENANCE SYSTEM (RPMS) USING SIMULATION MODELING
Authors: Aliev M.M. , Ismagilova Z.F. , Gimranov A.M. , Sozontova E.A.
Published: November 2023

The paper considers the optimization of reservoir pressure maintenance systems using simulation methods. The main goal is to consider the impact of various technological indicators on capital and operating costs. The initial parameters for calculating optimization options are the cost of electricity and the density of the injected water; fiberglass pipes (SPT-80, SPT -100) are used as pipes, the wall roughness of which is assumed to be 0.015 mm.The costs of capital construction during the reconstruction of pipelines and the pumping unit, as well as operating costs for overcoming hydraulic losses in pipelines, in well piping and for energy losses of pumping units are calculated. When calculating, special attention is paid to losses that make up 90% of the total power losses in the pressure maintenance system, such as power losses associated with imperfect pump design; power losses for choke of injection wells; losses of electricity for the operation of pipelines.The results are presented on the example of a small cluster pumping station. 4 options for optimizing calculated in terms of capital and operating costs for three main points are presented: pumping equipment, pipelines and wells. To assess the impact on production, a reservoir model was built using the material balance method. It should be noted that synthetic data were used for this case, because in reality, this CPS is just a part of the pressure maintenance system.When optimizing 20 facilities, the following results were obtained: on average, over 20 years, the difference in operating and capital costs between the basic reconstruction option and the most profitable reconstruction option with optimization is about 350 million rubles.
MODELING TOOLS USED FOR OPERATIONAL FIELD DEVELOPMENT MANAGEMENT
Authors: Semanov A.S. , Semanova A.I. , Fattakhov I.G. , Kotenev Y.A. , Sultanov S.Kh.
Published: November 2023

The increase in the share of hard-to-recover reserves increases the need to use modern technologies in the development of oil fields to increase the efficiency of reserves development. One of the tools for identifying zones with hard-to-recover reserves is the geological and hydrodynamic model, which allows simulating various geological and technical measures carried out on production and injection wells. It is possible to lay down both predicted and already carried out measures for testing hypotheses and making decisions on field development. In this work, we have considered the area where the problem of premature water flooding of products has been identified from a certain period of time. After an analytical review of the site, a theory was put forward about the source of water flooding. In the analyzed area there is also a horizontal well, which is not currently in operation. The well was fractured immediately after drilling. The well was put into operation with a high water cut and shut down, and no crossflows were detected during additional field geophysical surveys. In terms of indirect parameters (properties of produced water, pressure, parameters during hydraulic fracturing), the created fracture overcame the clay bridge and created a hydrodynamic connection with the underlying aquifer. Based on the analysis, a theory was put forward that the formation water of the lower aquifer along the fracture of the frac migrated to the zone of extraction of the productive oil formation due to the large difference in the current formation pressure between the facilities. The hypothesis is confirmed by calculations on the hydrodynamic model. Several options were proposed at the end of the site to slow further water breakthrough to the production wells. Among them, the injection of various polymer-based compositions into a horizontal well is a «source».
Yield Statistics of Grain Crops in Siberia in the 1920s
Authors: Il`inykh Vladimir
Published: November 2023

The USSR crop yield statistics in the 1920s was based on the methods that had been used in the Russian Empire. Its monitoring was focused on the consecutive collection of information on species and biological yields, the results of the first harvests from voluntary correspondents, and was concluded in sample autumn surveys of peasant farms. The average yield in the subordinate territory was determined by regional expert commissions. The yield calculated on the basis of the processing results of the received materials was multiplied by the crop area. In the 1920s, peasants would conceal the size of their crops and cultivated areas from accounting, as they saw fiscal purposes in the actions of state statistical representatives. Statistical agencies, in order to find out the extent of undercount, carried out control measures, used the materials of budget and other surveys. Improving the methodology for determining the magnitude of the undercount led to periodic adjustments to the official data. As a result, it was impossible to plot sufficiently extended annual series of the dynamics of crop yields and gross yields of grain crops in Siberia in the 1920s. Nevertheless, the available statistical materials make it possible to determine the main trends in the grain production dynamics.
Siberian Fairs in the Foreign Trade System of the Russian Empire in the XIX Century
Authors: Shkunov Vladimir
Published: November 2023

The article is devoted to the problems of integration of Siberia into the foreign trade system of the Russian Empire during the XIX century. Special attention is paid to the role and importance of Siberian fairs in Russia's export-import operations with the countries and peoples of the East, the ethno-confessional features of Siberian merchants’ participation in foreign trade, the characteristics of Siberia's leading fairs, the range of export and import goods, etc. The development of fair trade in the macroregion contributed to the active inclusion of Siberia in the all-Russian economic processes and the formation of a single economic space. During the century, the number of fairs increased significantly, including those in remote and hard-to-reach areas, where fur trappers from among the small indigenous peoples brought their fur goods. The author provides examples of the activities of large trading houses, the Russian-American Company for the purchase of Siberian goods for their sale abroad, as well as the sale of imported goods at Siberian fairs. He analyses the reasons for the movement of Chinese and Central Asian merchants into the interior of Siberia with goods that were in steady demand at the bazaars. The importance of the development of transport routes (including river ones) in the development of both fair and foreign trade in the period under review is noted. The construction of the Trans-Siberian Railway (the Great Siberian Way) and the Manchurian Railway contributed to the expansion of Russian-Eastern trade through Siberia, strengthening the positions of leading fair-trade centres near the railways. By the end of the century, Siberia's foreign trade relations had spread to remote regions of Asia: domestic goods purchased at Siberian fairs could be found in Shanghai and Hong Kong, Japan and Korea, the Philippines and Singapore, etc.
Sociocultural Factors in Economic Development: Problems of History and Theory
Authors: Kazantsev Yuri , Zaikin Nikolay
Published: November 2023

The article is an attempt to answer the question: “How does culture manifest itself in the economy?” For this purpose, the authors analyzed approaches of various schools of economic theory in regard to the assessment of the role of sociocultural factors in the economic development. Reference to scientific primary sources allowed the authors to point out seemingly insignificant examples of manifestation of the cultural factor in the economy in the works of Russian and foreign authors, which, at the same time, possess important conceptual meaning for the study of the problem in question. The paper proposes to consider the study of the place and role of culture in the economy as a step-by-step process: from the description of examples of the manifestation of culture in the economic space of the historical school to the conceptual model of the cultural factor in the sociocultural economy. Using the works of representatives of German Historical School, of institutional economists and researchers of sociocultural economics school, the authors try to present the regularities of culture functioning in the form of verbal formulae or synopses, for example about the significance of cultural factor in the economy, about the durability and reproductive nature of the culture, about culture as a frame through which economic decisions are made, etc. At the end of the article, the authors make a conclusion that it is necessary to take into account sociocultural factors in the implementation of the operational, tactical and strategic economic policy of the state.
Issues of Strengthening Labour Discipline in the Years of the New Economic Policy (Case Study of the Tula Cartridge Works)
Authors: Volodin Sergey
Published: November 2023

The issues of strengthening labour discipline in the years of the New Economic Policy are the subject of this research. The author examines them in the unity of factory production process and macroeconomic circumstances of the period using the example of employee behaviour of the Tula Cartridge Works munition workers. The author states that during the first years of the new period, due to the pressure of unemployment and competition on the labour market, the labour discipline of the Tula cartridge makers was changing for the better. However, the increased labour turnover and the decline in workers’ skills created serious contradictions between different categories of workers at the workshop level. Together, they defended their measure of control over workplace behaviour by formally seeking protection from workers' organisations and informally by turning to implicit resistance practices. In the second half of the 1920s the labour discipline situation in the enterprise aggravated again. The general irritation of the workers was provoked by a worsening of cash and non-cash payments they got against the background of labour intensification campaigns. Under these conditions, the management team of this enterprise, like the leaders of labour collectives throughout the country, had to adhere to a compromise tack. Overall, in the author’s opinion, an acceptable level of labor discipline was achieved within the historical context of the New Economic Policy.
Stereotaxic Injection by Nanoject Protocol v2
Authors: Institute for Brain Science Allen
Published: November 2023

This protocol describes the delivery of a neuronal tracer using the Nanoject II. The surgery uses a stereotaxic system to target specific brain coordinates in the mouse. Note: Research reported in this publication was supported by the National Institute Of Mental Health of the National Institutes of Health under Award Number U19MH114830. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Cost-effectiveness analysis of encorafenib and binimetinib combination as first-line treatment for metastatic or unresectable BRAF V600-mutated metastatic melanoma in Russia
Authors: Avxentyev N. A. , Makarova Yu. V.
Published: November 2023

Objective: to perform a cost-effectiveness analysis of using encorafenib and binimetinib combination in the first-line therapy for metastatic or unresectable BRAF V600-mutated melanoma in the Russian Federation.

Material and methods. The comparators included “dabrafenib + trametinib” combination and vemurafenib monotherapy, which are listed in the Russian clinical guidelines and the Vital and Essential Drugs List. Since “encorafenib and binimetinib” combination demonstrated superior overall response rate compared to “dabrafenib + trametinib” and vemurafenib monotherapy, the method of cost-effectiveness analysis was used. We developed a disease progression model based on data from the COLUMBUS randomized control trial and published network meta-analysis. The model was used to calculate the direct medical costs associated with the considered alternatives over a 3-year modeling horizon. We compared the incremental cost-effectiveness ratio for “encorafenib + binimetinib” vs. “dabrafenib + trametinib” to the same ratio calculated for “dabrafenib + trametinib” vs. vemurafenib monotherapy.

Results. Mean costs of using “encorafenib + binimetinib” combination over a 3-year period, considering the discontinuation of treatment as the disease progresses, was 6,547,693.07 rubles. Meanwhile, it was 5,962,742.52 rubles for “dabrafenib + trametinib” and 2,581,781.45 rubles for vemurafenib monotherapy. The incremental cost-effectiveness ratio of “encorafenib + binimetinib” vs. “dabrafenib + trametinib” was 3,846,818.71 rubles per 1 patient with a response to therapy. This was 85.14% lower than the same ratio estimated for “dabrafenib + trametinib” vs. vemurafenib monotherapy (25,890,022.64 rubles per 1 patient with a response to therapy).

Conclusion. The “encorafenib + binimetinib” combination is a cost-effective treatment method for patients with unresectable or metastatic BRAF V600-mutated melanoma in the Russian Federation.
An open-label, controlled trial of the clinical effects of Laennec® in patients with nonalcoholic steatohepatitis or cirrhosis
Authors: Imawari M. , Nagase M. , Torshin I. Yu. , Gromova O. A.
Published: November 2023

Objective: to evaluate the efficacy and safety of human placenta hydrolysate (HPH) Laennec® in the treatment of nonalcoholic fatty liver disease (NAFLD) in a clinical trial.

Material and methods. The study involved hospitalized NAFLD patients (with non-alcoholic steatohepatitis, cirrhosis) (n=34, mean age 53±14 years). In the therapy group (n=17), patients received Laennec® HPH (4 ml intravenous drip infusion in a solution of 5% glucose 5 times a week for 2 weeks). In the control group (n=17), patients hospitalized in other departments of the clinic did not receive any therapy for NAFLD. The effectiveness of therapy was assessed after 2 and 3 weeks by subjective NAFLD symptoms (fatigue, anorexia, bloating, constipation, nausea, and pain in hypochondrium) and biochemical indicators of liver function: levels of blood serum aspartate aminotrans-ferase (AST), alanine notransferase (ALT), gamma-glutamyltransferase (GGT).

Results. At the start of the study, there were no significant differences between the groups in the values of the studied indicators of liver function: blood levels of AST, ALT, GGT, etc. By the end of Week 1, a significant decrease in AST levels was registered in the group receiving Laennec® (–35 U/l; control: –8 U/l; p<0.001), ALT (–45 U/l; control: –10 U/l; p<0.001), and GGT (–23 U/l; control: –8 U/l; p=0.084; trend). At the end of the study (Week 3), the decrease in AST, ALT and GGT levels towards the normal range was even more pronounced for all three biomarkers: AST (–62 U/l; control: –23 U/l; p<0.001), ALT (–78 U/l; control: –20 U/l; p<0.001), GGT (–40 U/l; control: –15 U/l; p=0.005). Subjective NAFLD symptoms significantly improved after 3 weeks. No adverse effects were identified with the use of HPH.

Conclusion. Laennec® is an effective and safe treatment for NAFLD.
Efficacy of alectinib in comparison with lorlatinib in patients with ALK-positive non-small cell lung cancer: pharmacoeconomic study
Authors: Kolbin A. S. , Gomon Yu. M. , Proskurin M. A. , Balykina Yu. E.
Published: November 2023

Objective: to evaluate the clinical and economic effectiveness of alectinib in comparison with lorlatinib in adult patients with advanced anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer (NSCLC).

Materials and methods. The calculations included the direct costs of the healthcare system: the costs of drug therapy, detecting and relieving adverse events, palliative care. A Markov model consisting of three patient states (“alive without progression”, “alive with progression”, “death”) was constructed, the probabilities of which were obtained from previously conducted clinical studies. Due to the equivalence of strategies regarding overall and non-progressive survival, the cost minimization analysis was applied.

Results. The total costs per 1 patient when using lorlatinib were 40.63% higher than for alectinib (12,551,770 and 7,451,522 rubles, respectively). At the same time, the difference was mainly determined by different costs of targeted therapy: in the alectinib group, the cost of drug therapy per 1 patient amounted to 6,646,247 rubles, in lorlatinib group – to 11,922,814 rubles (44% higher).

Conclusion. The use of alectinib in the treatment of patients with ALK-positive NSCLC is justified not only from clinical, but also from an economic point of view.
The Impact of Hypothyroidism on Clinical Outcomes in Patients Undergoing Percutaneous Coronary Intervention
Authors: Shanmuganathan Gokila. , D. Anandhi , K. Revathi , Subban Vijaya Kumar , Kumaran Senthil , Mullasari Ajit S. , Anandan Harini
Published: November 2023

Introduction: Hypothyroidism either subclinical (SCH) or overt is independently associated with an increased risk of coronary artery disease (CAD). The combined effects of SCH and overt hypothyroidism on clinical outcomes after percutaneous coronary intervention (PCI) are largely unknown. Aim: The aim of the study is to assess the impact of subclinical and overt hypothyroidism among patients presenting with CAD undergoing PCI. Materials and Methods: A total of 102 patients who were referred to the Madras Medical Mission Hospital for PCI from September 2020 to March 2021 were enrolled in the study. These patients were categorized into three groups. Each group has 34 patients and was followed for one year. Group 1: Patients with normal TSH levels (TSH-0.45 -5mlU/Liter) and euthyroid at T3, T4 levels. Group 2: Patients with subclinical hypothyroidism with elevated TSH levels (TSH=5-15mlU/liter) and normal thyroid with T3, T4 levels. Group 3: Patients with a family history of overt hypothyroidism or high TSH levels(<15mlU/liter) and low T3 and T4 levels [16]. Results: We applied ANOVA to find the PCI outcomes. A p-value of <0.05 was accepted as significant. Age (p-0.03), recent myocardial infarction (p-0.04), diabetes mellitus (p<0.001), HbA1C (p-0.012), and systolic blood pressure (p-0.04) were found to be significant. Post-PCI bleeding complications (p<0.001) during one month, six months, and one-year follow-up were the main observation of the study. Conclusion: The prior history of DM and elevated HbA1c levels observed in the overt hypothyroid group indicate that DM was one of the key factors associated with overt hypothyroidism. Despite the fact that PCI was safe for patients with hypothyroidism, the risk of early post-PCI bleeding was of concern.
Detection of Aspergillus Sp Fungus in Tuberculosis Patients with A Treatment Length of 2 Months using the Polymerace Chain Reaction (Pcr) Method
Authors: Faidha Muzriatul , Muh. Nasrum Massi  , Irawati Djahruddin  , Rosana Agus  , Yuyun Widianingsih  , Firdaus Hamid
Published: November 2023

This study aims to detect the presence or absence of the Aspergillus sp fungus in Tuberculosis Patients within a 2 month treatment period. This research was carried out in the Microbiology Laboratory at Hasanuddin University Teaching Hospital. Laboratory methods. Samples were obtained from the Tabaringan and Pattingaloang Community Health Centers in Makassar City. Then testing was carried out using culture techniques and polymerace chain reaction techniques. The research results showed that by using the culture method from 30 samples, 9 samples obtained growing media, for 2 samples it was suspected that Aspergillus sp fungus was growing. Then for the polymerace chain reaction (PCR) method, from 30 samples the presence of Aspergillus sp fungus was detected, 4 samples using ASAP primers, then carried out again using ASPU primers (ASPU+Af3r, ASPU+Ni1r, ASPU+Fl2r) which resulted in 1 Aspergillus niger sample. From the results of this research, it can be concluded that the factor that causes the growth of fungus is the long-term administration of anti-tuberculosis drugs which only suppress bacteria from pulmonary tuberculosis.
Childhood Health and Growth Trends: A Cross-Sectional Study of School Children
Authors: Ranju Raj Rajendran , V. Anjali , Babu Shyamaladevi , Krishnan Madhan , Asir Billy
Published: November 2023

Childhood is a pivotal phase of human development, entails rapid growth and evolving health requirements. This cross-sectional study examines the age and sex distribution of school children across five coastal localities. To address the unique health and well-being challenges faced by school children in different regions, this cross-sectional study explores the age and sex distribution of school children across five distinct localities: Koilpathu, Karaikalmedu, Nallathur, Varichikudy, and Kottucherry. It offers a comprehensive examination of school children, encompassing demographic profiles, anthropometric measurements, and a wide array of health-related data. Our analysis revealed shifting gender proportions across age groups, with females dominating in the younger years but males surpassing females as children grow older. Particularly intriguing were the 12-year age group's scarcity of females (0.3%) and the 13-year age group's exclusive female composition (6.07%). Regarding body mass index (BMI), boys generally exhibited values near reference standards in their early years, while girls displayed lower BMI values than the reference during pre-adolescence, signaling potential nutritional concerns. Malnutrition was less prevalent in younger age groups, but overweight and obesity became more common as children aged. Gender-specific health disparities were also evident, with females more susceptible to anemia, while males had a higher prevalence of color blindness and dental health issues. These findings underscore the importance of tailored interventions to address age and gender-specific health challenges among coastal school children.
Advances in Drug Formulation Technology: Enhancing Bioavailability and Patient Compliance
Authors: Manipriyanka K  , Ravi Kishore Naidu
Published: November 2023

Drug formulation technology is continuously evolving to improve the efficacy and patient experience of pharmaceuticals. This paper explores recent advancements in drug formulation techniques aimed at enhancing drug bioavailability and promoting patient compliance. By addressing challenges related to drug solubility, stability, and delivery, these innovations have the potential to revolutionize drug development and patient care. This paper provides an overview of these advancements, their mechanisms, and their impact on the pharmaceutical industry and healthcare.