bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategi Guru dalam Membentuk Karakter Siswa Melalui Pendidikan Karakter Siswa SDN 060914 Medan
Authors: Sitanggang Rizka Pahmawati Regina , Simanjuntak Sinta Dameria , Manullang Six Martawati , Gurning Riris
Published: March 2024

This study aims to determine the impact of character education on the character of students at SDN 060914 Medan. The approach in this study uses a quantitative descriptive approach with survey methods. The sampling technique uses a purposive sample, namely by taking samples from fifth grade students with a total of 20 students. The research instruments used were interviews, questionnaires, and observation. The results of the research show that students' behavior in implementing character education which includes religious, honest, diligent, disciplined, and caring/responsible characters is in the pretty good category. As for the constraints on the lack of cooperation from parents to further foster students when they are at home, as well as their daily social environment. So the solution to these obstacles is to hold meetings with parents at the end of each semester.
Keefektifan Model Pembelajaran Problem Solving Berbantuan Video Interaktif Terhadap Kemampuan Pemecahan Masalah Siswa Kelas III SDN Gedawang 01 Semarang
Authors: Ardita Serandha , Putra Lisa Virdinarti
Published: March 2024

The purpose of this study is to determine the effectiveness of the problem solving learning model on the problem-solving ability of grade III students of SDN Gedawang 01 Semarang. This type of research is quantitative research with a problem solving learning model using interactive videos. The population in this study was grade III SDN Gedawang 01 and grade III SDN Gedawang 02 Semarang totaled 56 students. Meanwhile, the sample, namely class III SDN Gedawang 01, was 28 students. Data collection techniques in the form of observations, questionnaires, interviews and tests. The technical data analysis used is the Independent Test sample T-test and the Simple Linear Regression Test. The results showed that: there was a difference in the average problem solving ability of students between the control class and the experimental class, which can be seen from 1) Independent Test T-test sample and obtained thitung > ttabel (3.83 > 2.13) with a sig value. (2 -tailed) i.e. 0.001<0.05 then Ho is rejected and Ha is accepted. 2) There is an effectiveness of interactive video-assisted problem solving learning models, which can be seen from the Simple Linear Regression Test and obtained a signification level of F 67.195, sig:0.000a < 0.05. So it can be concluded that the interactive video-assisted problem solving learning model is effectively used to improve the problem-solving ability of grade III students of SDN Gedawang 01 Semarang.
Keefektifan Model Pembelajaran Contextual Teaching and Learning Berbasis Teknologi Informasi untuk Meningkatkan Rasa Percaya Diri dan Hasil Belajar Siswa
Authors: Maulana Andi , Sutono Agus , Sumarno Sumarno
Published: March 2024

The background that drives this research is the low level of self-confidence in the cognitive learning outcomes of fifth grade elementary school students in Tlogohendro village. This type of research is quantitative research in the form of pre-experimental with the type of one group pre-test and post-test design. The population of this study were fifth grade elementary school students in Tlogohendro village for a total of 35 in the 2022/2023 academic year with a saturated sample. The data in this study were obtained through tests and documentation.The posttest results showed that the percentage of classical group learning completeness at both SDN 01 Tlogohendro, SDN 02 Tlogohendro and SDN 03 Tlogohendro reached 100%. And based on the analysis of student learning outcomes, t'count (36.74) > ttable (1.7), thus Ha is accepted, which means that there is a significant difference in scores between before and after students apply contextual teaching and learning based on information technology.So it is concluded that the contextual teaching and learning model based on information technology is effective in increasing the self-confidence and cognitive learning outcomes of class V state elementary school students in Tlogohendro village.
Plan piloto para el mejoramiento de la calidad nutricional y conteo de células somáticas de leche bovina, producida por pequeños productores de la provincia de Pichincha-Ecuador, aplicando un programa de capacitación
Authors: Puga-Torres Byron , Meneses Cunama Dennisse Carolina , Meneses Pineda James Orlando , Montenegro Almeida María Carolina , Morales Pérez Ismael Demóstenes , Guanoluisa Vargas César Raúl , Villarreal Tania
Published: March 2024

La producción láctea en Ecuador es una fuente de ingresos económicos para muchos pequeños y medianos productores; sin embargo, la falta de asesoría técnica conlleva a que tengan problemas en la calidad de la leche y se vea afectado su volumen de producción, por lo que la presente investigación tuvo como finalidad realizar un plan piloto para el mejoramiento de la calidad de leche producida por 57 pequeños productores de diferentes parroquias de los cantones Quito, Rumiñahui y San Miguel de los Bancos de la provincia de Pichincha, mediante un plan de capacitación en buenas prácticas de ordeño y estrategias de alimentación. Se realizaron 2 muestreos iniciales (entre octubre y noviembre de 2021), previo a la capacitación, y 2 muestreos finales (en junio de 2022) para medir el impacto de estas. Se recolectaron 1.273 muestras, donde solamente el 4,02 % (52/1.273) de las mismas, cumplen con los valores referenciales de la normativa nacional, mientras que el 95,98 % (1.243/1.273) no cumple con alguno de los parámetros evaluados; sin embargo, la gran mayoría de dicha leche sí es apta para el consumo humano, pero requiere ser mejorada en su calidad nutricional. Se logró disminuir considerablemente (aunque no estadísticamente) el conteo de células somáticas, de un promedio inicial de 623.530 CS ml-1 a 365.660 CS ml-1 luego de la capacitación, siendo correlacionado con el aumento significativo del porcentaje de lactosa entre el muestreo inicial y el final; también existió diferencias significativas en el porcentaje de grasa y sólidos totales, aunque en estos dos casos disminuyeron sus valores luego de la capacitación (grasa de 2,58 % en el muestreo inicial a 2,10 % en el final y sólidos totales de 11,44 % a 11,00 %). El resto de los parámetros no mostraron diferencias significativas entre los muestreos. Se concluye que la capacitación fue beneficiosa, pues la disminución considerable del conteo de células somáticas aumentó el volumen de producción de leche de los pequeños productores y, por ende, sus ingresos económicos. Para el resto de los parámetros se recomienda reforzar las capacitaciones de nutrición, alimentación, manejo de pasturas, etc., para incrementar sus valores, así como mantener constantes programas de capacitación a los productores, apoyados desde la academia, la empresa privada y entidades públicas.
Analisis Hubungan Antara Minat dan Motivasi Belajar Terhadap Prestasi Belajar Siswa
Authors: Revikasya Afriza Kazwani , Nurnabilah  , Rokhmat Joni
Published: March 2024

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh minat dan motivasi belajar terhadap prestasi belajar siswa SMA Negeri 2 Langgudu. Sampel yang digunakan adalah 20 siswa yang di peroleh dengan pengisian kuisioner. Pengumpulan data dengan kuesioner (angket) untuk mengukur minat dan motivasi belajar, sedangkan prestasi belajar siswa diperoleh dari presentase minat dan motivasi belajar siswa. Metode dalam penelitian ini adalah survey dengan menggunakan tehnik analisis korelasional, yaitu mencari hubungan dan pengaruh antara dua variabel bebas dengan satu variabel terikat. Metode ini memberikan gambaran tentang variabel-variabel yang ditemukan, sekaligus menyelidiki hubungan dan pengaruh antara variabel, karena itu metode ini akan mengungkapkan data faktual berdasarkan informasi yang ditemukan. Hipotesisnya, yaitu 1) Mengetahui pengaruh minat dan motivasi belajar secara bersama-sama terhadap prestasi belajar fisika siswa SMA Negeri 2 Langgudu. 2) Mengetahui pengaruh minat belajar terhadap prestasi belajar matematika siswa SMA Negeri 2 Langgudu 3) Mengetahui pengaruh motivasi belajar terhadap prestasi belajar fisika siswa SMA Negeri 2 Langgudu. Berdasarkan hasil analisis diperoleh motivasi dan minat belajar siswa mempunyai hasil yang signifikan terhadap hasil prestasi belajar siswa, dimana minat dan motivasi belajar yang tinggi akan meningkatkan prestasi belajar siswa.
The Effect of Fermented Jicama Extract with Lactobacillus plantarum B1765 as the Culture Starter on the Product Quality and Flavonoid Contents
Authors: Salsabila Widi , Wikandari Prima Retno
Published: March 2024

Jicama (Pachyrhizus erosus) is a functional food containing phenolic compounds, with the main compounds being flavonoids. However, the presence of polyphenol oxidase and the structure of flavonoid compounds are still bound in the form of glycosides, so the bioactivity of jicama is not maximized. This study aims to determine the effects of jicama extract fermentation on product quality and increased flavonoid content in jicama. Fermentation was performed for 0, 12, 24, and 36 hours with 5% (v/v) of the starter culture, Lactobacillus plantarum B1765, at 37ºC. The result showed that fermentation times could increase Total Lactic Acid Bacteria (LAB), Total Tertitrable Acid (TTA), Total Phenolic Content (TPC), and Total Flavonoid Content (TFC). It also influenced a decrease in pH. The total LAB count was determined using the Total Plate Count method, the Total Tertitrable Acid was determined using acid-base titration, and the pH was determined using a pH meter. Total Phenolic Content was measured using the Folin-Ciocalteu method, and Total Flavonoid Content was measured using AlCl3 and potassium acetate. The analysis of the data revealed that jicama extract fermented optimum after 24 hours, with a total LAB count of 9.7x107±0.31 CFU/mL, a pH value of 4.21±0.22, a TTA of 0.376±0.025%, but TPC and TFC still increasing until 24 hours of fermentation to 16.22±0.312 mg GAE/g, and of 29.01±0.641 mg QE/g respectively. Fermentation of jicama extract with Lactobacillus plantarum B1765 increased total phenolic and total flavonoid contents and could be used as a functional food product.
Status Trofik Perairan Danau Laguna, Kota Ternate Selatan, Maluku Utara
Authors: Samman Ardan , Sabar Mesrawaty , Abjan Fabanjo M. , Rina Rina , Serosero Rugaya , Abubakar Salim , Sunarti Sunarti
Published: March 2024

Water quality and trophic status of waters play an important role in aquaculture activities because they will affect the growth process of cultivated fish, if the water quality and trophic status are low then they can support aquaculture activities in the waters of Laguna Lake, South Ternate City. The purpose of this study was to determine the water quality and trophic status in the waters of Laguna Lake in supporting and supporting freshwater aquaculture activities. The research method used in this research is descriptive qualitative, the results of air analysis are described based on Class and Water Quality Standards, while the trophic status is estimated based on Carlson, 1977. The results of the analysis show that the water quality in Laguna Lake is still in accordance with Class II Quality Standards. PP No. 22 of 2021, while the trophic level status in Laguna Lake is also classified in the oligotrophic category, namely TSI <40, TSI in Laguna Lake waters ranges from 20.69-23.28. Based on the results of the analysis of water quality and trophic status, it was found that the waters of Laguna Lake are still good and can support freshwater fish farming activities
Artrite Psoriática e o seu Desafio Diagnóstico: Relato de Caso
Authors: Garuta Ina , Barros Cardoso Sérgio , Terroso Lira Luís , Magalhães Alice , Cerqueira Marcos , Paulo Costa Luís
Published: March 2024

A artrite psoriática (AP) apresenta-se, habitualmente, como uma oligoartrite ou monoartrite, e pode constituir um desafio diagnóstico na ausência de história de psoríase.Relata-se o caso de um paciente de 57 anos que recorreu ao Médico de Família (MF) após um ano de evolução de sinais inflamatórios e onicólise do 3º dedo da mão direita. Os exames iniciais mostravam sinais inflamatórios dos tecidos peri-ungueais até à articulação interfalângica distal, e parâmetros inflamatórios analíticos negativos. O quadro foi interpretado em contexto infecioso e, posteriormente, como osteoartrose, não tendo existido melhoria com os tratamentos instituídos. A doença e o atraso no diagnóstico tiveram significativo impacto psicológico e profissional no paciente.Este caso relata uma apresentação rara de AP, podendo aumentar a suspeição diagnóstica desta entidade nos Cuidados de Saúde Primários, e evidencia o papel do MF no acompanhamento holístico e gestão das expectativas do paciente, além da articulação com as outras especialidades.
Um Caso de Delírio de Infestação nos Cuidados de Saúde Primários
Authors: João Sara , Albuquerque Rui Pedro , Lemos Inês
Published: March 2024

O delírio de infestação é uma perturbação que se caracteriza pela crença persistente de infestação por organismos vivos ou inanimados na ausência de evidência para tal. Perante as queixas é frequente os doentes recorrerem primeiramente ao médico de família ou a um dermatologista, ao invés de um psiquiatra, por não acreditarem que os seus sintomas são delirantes.Descrevemos o caso de uma doente de 86 anos que recorreu aos cuidados de saúde primários com história de ideias delirantes de infestação, acompanhadas de alucinações visuais e cenestésicas.Após investigação etiológica, o caso foi discutido com um colega de Psiquiatria do hospital da área de residência. Assumido o diagnóstico de delírio de infestação, foi iniciada terapêutica com risperidona, verificando-se a remissão completa dos sintomas.Este caso pretende alertar para a necessidade de os médicos de família reconhecerem esta patologia de forma a poderem orientá-la corretamente. Reforça ainda a importância da comunicação entre várias especialidades na gestão de perturbações semelhantes, que envolvem diagnósticos menos comuns, mas cuja abordagem inicial pode ser feita nos cuidados de saúde primários, desde que haja validação pela especialidade em questão.
Learning Disabilities and Epilepsy: About a Clinical Case
Authors: Freitas Fernandes Carolina , Ferreira Gonçalves Carolina , Rego Sousa Paulo
Published: March 2024

Landau-Kleffner syndrome (LKS) is an epilepsy syndrome of childhood, characterized by auditory verbal agnosia and severe electroencephalographic abnormalities. It happens between 3-7 years of age, 20% without seizures. A 6-years-old boy, with normal psychomotor development, who begins to experience difficulties in understanding the meaning of words, sometimes with incoherent speech and writing difficulties (irregular handwriting, spelling mistakes). Neurological evaluation showed loss of comprehensive language with auditory verbal agnosia, difficulties in fine motor skills and in graphomotor coordination. After clinical suspicion, the diagnosis of SLK was confirmed by night video-electroencephalogram (EEG): abundant paroxysmal activity of bilateral and independent fronto-center-temporal spikes and spike-wave activity, with an almost continuous exacerbation during sleep. Initially treated with valproate and clobazam, without improvement, he started prednisolone, with improvement in language, writing and normalization of the EEG. Knowledge of this syndrome is important for differential diagnosis with other neurological disorders, especially learning difficulties.
Hyperbaric Oxygen Therapy as a Complementary Treatment for Osteoradionecrosis of the Mandible: Useless or Useful? - A Literature Review
Authors: Alpuim Costa Diogo , Arana Ribeiro Joana , D'Espiney Amaro Carla
Published: March 2024

Radiotherapy (RT) is a key component of managing head and neck cancer patients. However, despite the emer gence and improvement of new RT techniques, late complications may occur, such as osteoradionecrosis of the mandible (ORNM). The diagnosis is based on clinical/radiological criteria. In the established ORNM, the chronic process does not solve spontaneously, and optimal management still needs to be established. Over the last decades, a broad therapeutic spectrum has been considered, including hyperbaric oxygen therapy (HBOT). Al though, the clinical impact of HBOT varies according to the literature, which is why there is a current controversy regarding its benefits. Further prospective and randomised studies are needed to validate its effectiveness in the ‘real-world’ clinical practice. This article aims to synthesise the existing data, analyse previous studies´ results, identify gaps in knowledge, and discuss ORNM’ management, including a proposal for an algorithm, with a par t icular focus on HBOT.
Ensino remoto de educação em saúde na pós-graduação em saúde coletiva: possibilidades no contexto da pandemia de covid-19
Authors: Pereira Deborah Santana , Morais Ana Patrícia Pereira , Pequeno Alice Maria Correia , Guimarães José Maria Ximenes
Published: March 2024

O ensino remoto emergencial ocasionou mudanças no processo de ensino-aprendizagem, requisitando criatividade e incorporação de novas estratégias pedagógicas. Objetivou-se relatar experiência de ensino-aprendizagem de  “Educação em Saúde”, num Programa de Pós-Graduação em Saúde Coletiva. Trata-se de um relato de experiência sobre o ensino remoto de Educação em Saúde na pós-graduação strito senso em Saúde Coletiva, de uma Universidade pública cearense, no período letivo  2021.1.  A disciplina foi ministrada por meio da plataforma Google Meet®,  com a adoção de estratégias ativas de ensino-aprendizagem. Evidenciou-se que os conteúdos foram relevantes,  estabelecendo-se articulação teórico-prática e respeitando-se aos saberes prévios dos pós-graduandos.  Buscou-se superar o modelo tradicional de ensino, com vistas a promover aprendizagem significativa.  Os desafios e as possibilidades identificadas permitem a reflexão sobre a práxis docente, no que tange o estímulo à participação e engajamento discente em ambiente virtual, além da incorporação de estratégias ativas de ensino, sobretudo no ensino remoto.
Mediação de saberes na sobrevivência ao câncer de laringe: a experiência de pessoas Laringectomizadas Totais
Authors: Ribeiro Fabiana Felix
Published: March 2024

O presente estudo parte de reflexões acerca da sobrevivência ao câncer e da experiência estigmatizante vivenciada por pessoas diagnosticadas com câncer de laringe no Hospital Nacional do Câncer/Instituto Nacional do Câncer, submetidas à cirurgia de Laringectomia Total e participantes do Grupo de Laringec­tomizados Totais. O objetivo foi compreender as mediações de saberes e de informações produzidas pelos participantes do grupo na interface com os profissionais de saúde, considerando a sua dupla condição de estigma: o câncer e a deficiência. Parte-se de uma abordagem socioantropológica de caráter qualitativo e ex­ploratório que empregou os métodos de entrevista narrativa com cinco participantes. A análise foi realizada pelo método hermenêutico-dialético. Nos resultados destacam-se a busca pelo reconhecimento individual e social e a valorização da experiência frente aos saberes oficiais e o quanto as mediações extrapolam o espaço institucional. A mediação de saberes faz emergirem elementos significativos para o enfrentamento de uma cultura informacional dominante.
“O povo da rua”: outros desafios e perspectivas em saúde, políticas públicas e comunicação
Authors: Aguiar Maria Livia de Sá Roriz , Oliveira Alexandra
Published: March 2024

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Some aspects of laboratory diagnostics of ophthalmodemodecosis
Authors: Popova D. A. , Kursakova Yu. V.
Published: March 2024

Demodicosis occupies a leading position among all dermatoses. According to ICD-10, it is not distinguished as a separate disease; it belongs to the class of parasitic diseases. The relevance of studying the problem of ophthalmodemodecosis is caused by its high prevalence and contagiousness, chronic course, an open issue of the role of the Demodex mite in the occurrence of inflammatory eye diseases, as well as the lack of effective methods for treating and preventing this pathology. In addition, Demodex causes discomfort and contributes to the occurrence of cosmetic defects, which in turn worsens the patient’s quality of life.

The aim. To present a review of the literature data and our own results of laboratory diagnostics of ophthalmodemodecosis.

Materials and methods. The article presents clinical cases of demodectic eyelid lesions with different disease outcomes in case of similar treatment. Laboratory diagnostics included drawing up an acarogram. Epilated eyelashes were used as a material for detecting mites on eyelids. Counting of individuals was carried out using light microscopy; all forms of mite development were taken into account. The work presents the statistics on the frequency of examination of patients with suspected demodicosis at different times of the year, confirming the seasonality of this disease. The literature review included data on the history of studying the Demodex mite, existing hypotheses and theories about its pathogenesis, as well as the information on domestic and foreign methods of treating ophthalmodecosis, including modern hardware techniques.

Results. Demodex mites play a significant role in the development of blepharitis and blepharoconjunctivitis. It is important to consider that demodicosis can occur against the background of inflammatory eye diseases of another etiology. Therapy for  ophthalmodemodecosis currently remains complex, lengthy and  ineffective. When assessing the results of an acarogram, any detected stages of a mite are clinically significant, and there isn’t a direct relationship between the number of detected mites and the severity of clinical manifestations in all cases.
Organizational aspects of medical rehabilitation of patients with respiratory tuberculosis
Authors: Siraeva T. V. , Komissarova O. G. , Romanov V. V.
Published: March 2024

Background. Despite the visible successes of domestic phthisiology at the present time, the problem of medical rehabilitation of patients with tuberculosis remains relevant. In recent years, approaches to medical rehabilitation of patients with various diseases have changed significantly, which entail the need to consider a complex of rehabilitation measures for patients with tuberculosis from the perspective of the Procedures for organizing medical rehabilitation in adults and children and their integration into phthisiatric practice.

The aim. To study the organizational aspects of medical rehabilitation of patients with respiratory tuberculosis in the world and the Russian Federation.

Methods. We carried out an analysis of domestic and foreign literature, regulatory documents on the organization of rehabilitation for tuberculosis patients for 2018–2023 in electronic databases PubMed/Medline, Google Scholar using terms “tuberculosis, pulmonary/rehabilitation” in English and Russian languages.

The  results show a  growing amount of  factual information demonstrating the positive effect of pulmonary rehabilitation in patients with respiratory diseases, including tuberculosis. The analysis revealed defects in the organization of the medical rehabilitation system in the structure of medical care for tuberculosis patients in the Russian Federation. This concerns problems of routing, phasing, organizational models, human and material resources, standardization of the main components of the rehabilitation process, the significance and effectiveness of certain rehabilitation measures, which leads to low availability of rehabilitation care for tuberculosis patients. Deficiencies in the regulatory framework prevent the integration of medical rehabilitation into the practice of TB services.

Conclusion. Modern issues of organizing rehabilitation care for patients with tuberculosis require further study and  improvement. The  development of  a  system of medical rehabilitation of patients with tuberculosis helps to increase the effectiveness of treatment, to reduce the number of complications, disability, mortality due to tuberculosis, and to increase the duration and quality of life of patients.
Lysophosphatidic acid and itsreceptors: Role in bronchial asthma pathogenesis
Authors: Kytikova O. Yu. , Novgorodtseva T. P. , Denisenko Yu. K.
Published: March 2024

Lysophosphatidic acid (LPA) is a biologically active lipid mediator that regulates a number ofsignaling pathways involved in the pathogenesis of bronchial asthma. Attention to studying the relationship of LPA with LPA receptors (LPARs) and ion channels with transient receptor potential (TRP) is caused by their role in the initiation and development of bronchial obstruction, which suggests the development of new effective strategies for the treatment of bronchial asthma through blocking LPA synthesis and/or regulation of the activity of the ligand-receptor relationship.

The aim of the review. To summarize ideas on the role of lysophosphatidic acid and its receptors in the pathogenesis of bronchial asthma based on the analysis of articles published in English in 2020–2023 from the PubMed database.

Conclusion. The review summarizes recent literature data on the chemical structure, biosynthetic pathways and LPA receptors. It presents the information on the role of LPA, LPARs andTRP channels inthepathogenesis of bronchial asthma; summarizes the bronchial asthma therapeutic strategies targeting LPA, LPARs, andTRP channels. The review highlights not only a new perspective on understanding the mechanisms of initiation of asthmatic reactions, but also possible ways to manage them at the stage of correction of their development.
Restoration of adaptive cardioprotection impaired by metabolic syndrome in rats by the PPARα activation
Authors: Naryzhnaya N. V. , Derkachev I. A. , Kurbatov B. K. , Sirotina M. A. , Kilin M. , Maslov L. N.
Published: March 2024

Background. It is known that the protective effect of adaptation and conditioning influence is weakened in animals with metabolic syndrome. Metabolic syndrome may be the basis for the failure of cardioprotection in clinical settings.

The aim of the study. To identify the relationship between disorder in carbohydrate and lipid metabolism and a decrease in the effectiveness of the infarct-limiting effect of moderate chronic normobaric hypoxia; to check the possibility of correcting reduced cardioprotection by normalizing carbohydrate and lipid metabolism.

Methods. The  study included 64  Wistar rats. Metabolic syndrome was  induced by feeding animals a high-carbohydrate, high-fat diet for 84 days. Chronic normobaric hypoxia was carried out for 21 days in the following mode: 12 % O2 : 0.3 % CO2. Metformin at  a  dose of  200  mg/kg/day or  PPARα agonist WY14643 at  a  dose of 1 mg/kg/day were added to the drinking water of rats with metabolic syndrome during adaptation period to hypoxia. A 45-minute coronary occlusion and 120-minute reperfusion were performed, and the infarct size was determined. Indicators of lipid and carbohydrate metabolism, leptin, and adiponectin were studied in the blood serum.

Results. The infarct-limiting effect of chronic normobaric hypoxia was weakened in animals with metabolic syndrome. Infarct size showed a direct correlation with decreased glucose tolerance and serum triglyceride levels. Using metformin therapy did not lead to the restoration of the infarct-limiting effect of chronic normobaric hypoxia, while the  normalization of  lipid metabolism with the  use of  the  PPARα agonist WY14643 corrected the  impairment of  adaptive cardioprotection in  rats with metabolic syndrome.

Conclusion. The  lack of  cardioprotection at  chronic normobaric hypoxia in  rats with  metabolic syndrome is  associated with  impaired carbohydrate and  lipid metabolism. The PPARα agonist restores impaired lipid metabolism and adaptive cardioprotection.
Prevention and correction of behavioral disorders in rats with metabolic syndrome using a complex phytoadaptogen
Authors: Dzampaeva Zh. V. , Datieva F. S. , Takoeva E. A. , Nartikoeva M. I.
Published: March 2024

The aim of the study. To assess the possibility of correction and prevention of behavioral disorders in rats with metabolic syndrome using a complex phytoadaptogen (CPA).

Material and methods. The experiment was carried out on 30 male Wistar rats randomized into 3 groups: group 1 – control; group 2 – metabolic syndrome (MS); group 3 – treatment of metabolic syndrome using CPA. In groups 2 and 3, animals were on a high-carbohydrate and high-fat diet for 16 weeks. Group 3 received CPA for 14 days in drinking water after 16 weeks of a diet. CPA consists of official tinctures of Glycyrrhiza glabra, Rhodiola rosea, Acantopanax senticosus at a ratio of 1:2:1. Behavior was analyzed through the “open field” test using Realtimer software (Open Science, Russia). Data were analyzed using GraphPad Prism 8.03 software (GraphPad, USA).

Results. The experiment proved that metabolic syndrome is accompanied by increased anxiety (decreased horizontal (p  =  0.017) and  vertical (p  =  0.017) motor activity) and fear (increased periods of immobility (p = 0.011)) in the open field. When corrected with a complex phytoadaptogen, the time spent in the open and closed arms of the maze did not differ statistically significantly from the values of similar control indicators.

Conclusion. Based on the data obtained in the group 3 (no statistically significant differences with control) – decreased manifestations of fear and anxiety (increased orientation and research activity) – we can talk about the effectiveness of complex phytoadaptogens as an anxiolytic. The mechanisms underlying this result remain to be explored, emphasizing the role of the autonomic nervous system, leptin and ghrelin in behavior and the influence of complex phytoadaptogens on them.
Association of FoxP3+ T regulatory lymphocytes with epicardial adipose tissue thickness in patients with coronary heart disease
Authors: Kologrivova I. V. , Kharitonova O. A. , Dmitriukov A. A. , Kravchenko E. S. , Koshelskaya O. A. , Suslova T. E.
Published: March 2024

Background. Increase ofthe epicardial adipose tissue (EAT) thickness isassociated with development of inflammation and cardiovascular complications, however, there is no data on the relationship between EAT thickening and the number of immunosuppressive regulatory T lymphocytes.

The aim. To study the number of circulating T regulatory lymphocytes and nuclear translocation ofthe FoxP3 transcription factor in patients with stable coronary heart disease (CHD) depending on the epicardial adipose tissue thickness.

Materials and methods. We examined 30 patients with chronic stable CHD. The EAT thickness was measured by echocardiography. Patients were divided into groups depending on the presence and absence of EAT thickening above 5 mm (groups 1 and 2, respectively). Imaging flow cytometry was used to determine the number of T regulatory lymphocytes and the level of FoxP3 nuclear translocation. The concentration of cytokines and high sensitivity C-reactive protein (hsCRP) was determined using enzyme-linked immunosorbent assay in blood serum.

Results. Anthropometric indicators of obesity and the severity of atherosclerosis were comparable between groups. In group 2, there was an increase in low-density lipoprotein cholesterol concentration (p = 0.043), ratio of low-density lipoprotein cholesterol tohigh-density lipoprotein cholesterol (p = 0.017) and the concentration ofhsCRP (p = 0.044) andIL-1β (p = 0.005), adecrease in the number and relative count of Tregulatory lymphocytes (p = 0.020 andp = 0.026, respectively), aswellas thenumber of cells withFoxP3 nuclear translocation (p = 0.018) compared togroup1. According tomultiple logistic regression, the concentration ofhsCRP, IL-1β and T regulatory lymphocytes relative count in total were the predictors of EAT thickening (accuracy 80 %; sensitivity 75 %; specificity 84,6 %; AUC = 0.89).

Conclusions. Thickening of epicardial adipose tissue inpatients withcoronary heart disease is associated with a decrease in the number of T regulatory lymphocytes andFoxP3 nuclear translocation inthem in presence of comparable anthropometric parameters of obesity and the severity of coronary atherosclerosis.
Determination of Malondialdehyde, Nitric Oxide, Reduced Glutathione, Sialic Acid and Ceruloplasmin Levels in Sheep Liver Tissue With Hydatic Cyst
Authors: Kızıltepe Semistan , Okulmuş Çağlar , Merhan Oğuz , Mor Neriman , Uzlu Erdoğan
Published: March 2024

Cystic echinococcosis is a prevalent helminth-zoonosis that poses a significant threat to human and animal health worldwide. Although it typically shows an asymptomatic clinical course, it has been reported to cause many damages and biochemical changes in tissues and organism. The aim of this study was to investigate the concentrations of nitric oxide (NO), reduced glutathione (GSH), malondialdehyde (MDA), ceruloplasmin (Cp), and total sialic acid (TSA) in sheep liver tissue affected by cystic echinococcosis. The study was carried out on sheep between 4-5 years of age brought to the slaughterhouse in the Igdir territory. The livers were examined post-mortem for cystic echinococcosis and cystic structures. Sheep liver tissues that tested positive for protoscolex were designated as the ‘infected group’, while healthy sheep liver tissues without lesions were assigned to the ‘control group’. The results showed significantly higher levels of NO, MDA, Cp and TSA in the infected group compared to the control group (p<0.05), while GSH levels were significantly lower (p<0.05). These findings indicate that cystic echinococcosis in sheep is closely associated with mechanisms of inflammation, oxidative stress, and tissue damage. Moreover, our study provides insights into the oxidative response of cystic echinococcosis in liver tissue and enhances our understanding of the disease’s pathogenesis.
Governance And Digital Transformation: Analisis Ruang Kerja Virtual Melalui Perspektif E-Government Pada Pemerintahan Provinsi Bali
Authors: Ni Putu Kartika Cahyani  , I Putu Adi Permana Putra
Published: March 2024

Digital transformation in the government sector is a form of public service innovation. Since the COVID-19 pandemic, various digital-based innovations have emerged as solutions to the problems that occur. This effort was made to provide services to the community during the pandemic.  One of them is the presence of a virtual office as a work space platform that supports efficiency in providing public services. Virtual offices are a manifestation of an electronic-based government system (SPBE), administering government by utilizing technology, information, and communication. This system exists to realize effective, efficient, transparent, and accountable government governance. This article focuses on reviewing virtual offices as a digital-based public service from an e-government perspective. The study uses a qualitative descriptive approach with data collection techniques through literature studies, such as books, journal articles, websites, and other documents related to the research topic. The results of this research show that virtual offices are a form of government governance through digital transformation. A review from an e-government perspective shows that this system has demonstrated key elements in achieving successful e-government implementation. Among them are support, capacity, and value. Apart from that, the concept of dynamic governance shows that the virtual office is a form of transformational government governance that is able to answer the challenges of technological and information development. This supports dynamic government towards good governance.
KAUM MODERNIS DI NUSANTARA: GERAKAN PADERI
Authors: Br. Tarigan Sabilla Hidayani
Published: March 2024

Gerakan Padri merupakan gerakan dakwah Islam yang ada di Minangkabau, Sumatra Barat. Gerakan ini terjadi pada tahun 1821-1837, dakwah Islam ini menjadi perselisihan antara kaum Adat, kaum Padri dan kolonial Belanda. Tulisan ini bertujuan untuk memahami bagaimana gerakan padri yang terjadi pada masa itu dan mengetahui cara-cara berdakwah dalam Islam yang ada pada masa pra kemerdekekaan yang masih dilakukan sampai sekarang. Penelitian ini dilakukan secara kualitatif deskriptif, yaitu dengan menganalisa fenomena yang ada serta menjabarkannya di dalam dalam bentuk poin-poin. Berdasarkan penelitian ini, ditemukan bahwa pendakwah Islam sejak sebelum kemerdekaan sudah banyak yang belajar agama ke Timur Tengah, dakwah Islam dilakukan melalui ceramah di masjid-masjid, lembaga madrasah serta melalui perdagangan dan perkawinan. Pada masa selanjutnya hal ini tetap dilakukan sebagai metode dakwah dan menjadi sebuah komunitas Islam yang berbentuk lembaga pendidikan, organisasi masyarakat serta tradisi yang masih dilakukan hingga sekarang.
STRATEGI GURU AL-QUR’AN HADITS DALAM MENINGKATKAN KUALITAS BACAAN AL-QUR’AN SISWA KELAS X MAS PLUS AL-ULUM MEDAN
Authors: Nasution Syukri Kurniawan , Junaidi Junaidi
Published: March 2024

The Al-Qur'an is a guide or guide for Muslims, so as Muslims it is recommended that you be able to read the Al-Qur'an properly and correctly according to the rules of tajwid and tahsin. The quality of reading the Qur'an is very important in assessing the ability to read the Qur'an properly and correctly. This research was carried out to: (1) determine the quality of the Al-Qur'an reading of X MAS Plus Al-Ulum Medan students, (2) the strategies of Al-Qur'an Hadith teachers in improving the quality of Al-Qur'an reading of X MAS Plus Al students -Ulum Medan, (3) supporting and inhibiting factors for Al-Qur'an Hadith teachers in improving the quality of Al-Qur'an reading for class X MAS Plus Al-Ulum Medan students. This research is a qualitative research. This research is field research and this research is classified into descriptive qualitative research. The research data was collected by observing, interviewing and documenting.
PERAN MASJID AL-JIHAD DALAM MENGEMBANGKAN GERAKAN SOSIAL KEAGAMAAN KELAS MENENGAH DI PERKOTAAN
Authors: Zahrah Mutia
Published: March 2024

ABSTRAKPenelitian ini bertujuan untuk mengetahui bagaimana peran masjid Al-Jihad dalam mengembangkan gerakan sosial keagamaan pada masyarakat kelas menengah di perkotaan. Masyarakat kelas menengah rata-rata jarang mau memenuhi kebutuhan keagamaannya di masjid. Metode yang digunakan dalam penelitian ini adalah metode kualitatif. Studi kasus yang terkandung dalam penelitian ini menghasilkan data deskriptif seperti kata-kata tertulis atau tanya jawab yang dilakukan dengan para informan. Adapun teknik pengumpulan data dalam penelitian ini adalah wawancara, observasi, dan dokumentasi. Hasil penelitian ini menunjukkan bahwa banyak sekali peran Masjid Al-Jihad dalam mengembangkan gerakan sosial keagamaan pada kelas masyarakat menengah di perkotaan. Dari mulai pembelajaran ilmu fiqh, banyaknya komunitas Islam yang sering berkolaborasi dengan masjid Al-Jihad, Kata Kunci : Peran Masjid, Kelas Menengah
Assessment of the quality of determining the coordinates of air objects by cooperative radar systems for air surveillance
Authors: Svyd I.V. , Obod I.I. , Holovatenko S.V. , Datsko S.V.
Published: March 2024

In the presented work, based on the classification of airspace surveillance radar systems in the form: independent non-cooperative radar surveillance, independent cooperative radar surveillance, dependent cooperative radar surveillance; the quality of determining the coordinates of air objects by the systems under study was assessed. The place and role of these information systems in the information support of airspace control and air traffic control systems is shown. From the calculations carried out, we can draw the following conclusion that the sensitivity of measuring the height of an airborne object significantly depends on the geometry of the location of receiving points of a synchronous network of radar surveillance systems. As the distance between receiving points increases, the area covered by curves of equal sensitivity increases. It is substantiated that when using equal weight in the accuracy of range measurement and in measuring the altitude of an airborne object, the accuracy of the synchronization of the time scales of the receiving points is the value achieved by modern means of time synchronization. The use of the given methodology for assessing the quality of measuring the coordinates of air objects in a synchronous network of cooperative radar surveillance systems for airspace allows us to put forward requirements for the synchronism of time scales in a unified synchronous information network of radar surveillance systems when measuring the coordinates of air objects. It is shown that the price for improving the accuracy of determining the coordinates of air objects by a synchronous network of cooperative radar systems is the complication of the system due to an increase in positions, an increase in the number of transceiver paths, the need to synchronize emission processes, receive signals and control viewing modes.
AUTOMATIC CONTROL SYSTEM FOR SECOND-ORDER TECHNOLOGICAL PROCESS WITH TIME DELAY BASED ON STATE FEEDBACK CONTROLLER
Authors: Krivonosov Vladimir , Korenev Artem
Published: March 2024

The paper considers the construction of an automatic control system (ACS) for technological objects based on a state feedback controller with an observer continuously estimating the object state coordinates and the low-frequency component of the input disturbance. As an example, the paper considers the process of constructing an ACS for a technological object whose mathematical model can be represented as a serial connection of a second-order aperiodic link and a delay link. The invariant part of the ACS includes a control object and an actuator, the model of which is described by a first-order aperiodic link. The paper describes in detail the proposed procedure for developing the structure and determining the correction coefficients for the motion observer, which allows ensuring an acceptable speed of convergence of the observation process, taking into account the intensity of measurement noise of the object output signal. A comparative analysis of the quality of the developed ACS and an alternative ACS based on the PID-regulator is carried out. The parameters of the state regulator and the PID-regulator are configured in the mode of processing a step response in the absence of input disturbing influences. For configuration, procedures for multiple simulations of transients in MATLAB SIMULINK are used. The comparative analysis of ACS quality is performed according to engineering performance indicators of systems under various combinations of setting and disturbing influences. The results of the analysis show that the system with the state controller provides a significantly higher control quality in all control modes. The conducted studies allow recommending the development and implementation of ACS with an observer and a state regulator to improve the control efficiency of a fairly wide class of real technological objects, which can be described by a second-order aperiodic link with a delay.
Determinasi Sistem Manajemen Informasi Terhadap Kualitas Layanan Pendidikan Pada MTSN 1 Aceh Tengah
Authors: Fauzi Farid , Fari Alghi
Published: March 2024

Abstrak: Kemajuan sistem informasi manajemen pada saat ini menjadi kebutuhan pada dunia pendidikan khususnya institusi Pendidikan Islam yaitu MTsN 1 Aceh Tengah. Penelitian ini mengkaji tentang determinasi dari sistem informasi manajemen terhadap kualitas layanan  pada MTsN 1 Aceh Tengah. Pendekatan yang digunakan pada penelitian ini adalah kombinasi (Mixed Methods) dengan metode Sequential Explanatory. Jumlah sampel pada penelitian ini berjumlah 38 orang.  Berdasarkan hasil penelitian menunjukan bahwa terdapat pengaruh positif dan signifikan pada variabel sistem informasi terhadap kualitas layanan pada MTsN 1 Aceh Tengah dengan determinasi sebesar 55.05% dan persamaan regresi Y= 18,371 + (0,472)X.  Selain itu, berdasarkan hasil wawancara, observasi dan dokumentasi mengungkapkan bahwa proses sistem informasi manajemen berjalan dengan baik, sehingga mempermudah guru, siswa dan orang tua dalam berkomunikasi kepada madrasah dan mendapatkan informasi-informasi akademik, dengan mudah, sehingga dapat meningkatkan kualitas layanan madrasah kepada stakeholder dan Shareholder.
Analisis Beban Kerja Karyawan Perakitan Kemasan Bedak untuk Memenuhi Permintaan
Authors: Rifaldi Moch Fiqi , Mundari Siti
Published: March 2024

PT. XYZ is a Foreign Investment (PMA) company that specializes in the plastic cosmetic packaging printing industry and produces more than a thousand packaging variants. This research focuses on the assembly part of the DK-274 baby powder packaging. The problem found in this research is the delay in achieving the demand target which originates from worker fatigue due to work pressure and other factors during the production process. In this research, workload measurements will be carried out and determine the optimal or ideal number of workers to meet demand. By using several research methods, including work sampling and work load analysis (WLA), which functions to determine the workload and the optimal number of workers. After the method was applied, the results showed that assembly of the DK-274 baby powder packaging product required a manufacturing time of 1.40 minutes per product unit with an average workload of 109.04% (overload). From the results of this research, the labor solution used in assembly DK-274 baby powder packaging uses 7 workers and 1 automatic press machine. By calculating using work load analysis, it was found that there was no additional workforce. The production alternative requires the company to provide overtime for 7 workers. With this implementation, the company only incurs less costs compared to increasing the number of workers
Analisis Kelayakan Pendirian Usaha CV.Wisnu Motor di Jl.Leminggir Mojosari
Authors: Kusuma Wisnu Wijaya , Singgih Mochammad
Published: March 2024

The feasibility analysis for establishing a CV. Wisnu Motor business on Jl. Leminggir Mojosari aims to determine the feasibility of a company. In an analysis of the feasibility of establishing a business, it can be carried out through several aspects, namely a monetary perspective, a special perspective, a market perspective and an advertising perspective using the Net Present Value (NPV), Internal Rate of Return (IRR), Payback Period (PP) technique. ) and Profitability Index (PI). This analysis produces data that shows the NPV of the CV business establishment. Vishnu Motor for Rp. 1,974,607,419, with an IRR of 30.25%, then the PP for the business is 1 year 4 months 8 days, and the PI is 2.43. According to the existing analysis regarding feasibility here, it can be concluded that the CV. Wisnu Motor establishment business has fulfilled the feasibility of being established, because it has a positive NPV value, a higher IRR on funding costs, a relatively short PP, and a PI that shows greater than above.
Perancangan Sistem Informasi Pemesanan Tiket Travel Bengkalis (GOTralis) Berbasis Android
Authors: Farid Muhammad , Safitri Indah , Nabila Nabila , Putri Eka Susnita , Rahmayani Mentari Tri Indah
Published: March 2024

Technology at this time is something that is really needed to help make it easier to access everything efficiently, so an information system design has been developed which aims to make it easier for the public, especially in ordering travel tickets. So a design was built with the name GOTralis (GO Travel Bengkalis) as a means to help the public in ordering travel tickets. In this research, the author used the SDLC method, namely conducting a literature review regarding information systems, the web, SDLC, and application development tools. So this research can create a design that can make it easier for travel passengers to order travel tickets easily.