bluuebunny/crossref_metadata_2025 huggingface dataset:
Is Orthodontic Treatment with Microperforations Worth It? A Scoping Review
Authors: Maspero Cinzia , Cappella Annalisa , Dolci Claudia , Cagetti Maria Grazia , Inchingolo Francesco , Sforza Chiarella
Published: February 2022

Malformations of teeth and dental arches can produce functional modifications intermingled with esthetic alterations. Children’s rehabilitation may be long, requiring multiple interventions. One of the main challenges of contemporary orthodontics is to reduce treatment time by accelerating orthodontic tooth movements. Among the currently used methods, micro-osteoperforations (MOPs) are flapless, minimally invasive perforations that induce a local trauma to the bone, increase healing capacity, and accelerate dental movements. The use of MOPs in orthodontics is spreading but there are no definite and recognized protocols for their application. This scoping review collected the available evidence in the effect of MOPs during orthodontic therapy as compared to current treatments, to summarize the evidence. The guidelines proposed by PRISMA-ScR were followed: original clinical studies carried out from 2010 to 2021 were retrieved by medical databases combining the terms “micro-osteoperforations” and “accelerated orthodontic tooth movement”. From a total of 965 articles, nine were finally selected. The studies’ aims, designs, methods, measurements, outcomes, and main findings were very heterogenous, with a duration ranging from 4 weeks to 7 months. This included only Class I malocclusion to any malocclusion. It assessed the effects of MOPs coupled with a variety of orthodontic mechanics on either the retraction of maxillary canines, the distalization of maxillary molars, or the modifications on premolar roots. Mostly, variations in the number, location, and timing of MOPs impeded a global assessment. Overall, most of the studies (six out of nine) reported moderately useful effects of MOPs, one was negative, and only two found significant advantages of MOPs over conventional treatment. The review synthesized the available evidence about MOP applications in orthodontics and identified some important gaps in knowledge that could be starting points for a systematic review of the literature. In conclusion, even if MOPs can accelerate tooth movements, the variety of aims and methods of the published research prevents suggestion of their widespread use.
Continuous Wear of Night and Day Orthosis Is a Key Factor for Improvement of Fixed Equinus Deformity after the Transverse Vulpius Procedure
Authors: Wegner Mathis , Koyro Katharina I. , Kosegarten Louisa , Hell Anna Kathrin , Lorenz Heiko M. , Diedrichs Volker , Lippross Sebastian
Published: February 2022

Background: Equinus foot deformity is secondary to either spasticity or contracture of the gastrocnemius–soleus complex. The plantar flexion is basically treated conservatively; several different surgical methods have been discussed. This paper focuses on the improvement of passive ankle dorsiflexion after a transverse Vulpius procedure in equinus foot deformity. Additionally, the influence of consequent postoperative wear of orthosis on the improvement of ankle range of motion was investigated. Methods: In total, 41 patients with neuromuscular impairment and 59 equinus feet deformities were surgically treated by using a transverse Vulpius procedure. A total of 19 female patients and 22 male patients with a mean age at surgery of 10.18 years (2 to 31) were included. Mean follow-up took place 12.26 ± 7.95 months after surgery. Passive ankle dorsiflexion was measured and subjective patients’ satisfaction was assessed. Results: Range of motion, measured as the maximum of passive ankle joint dorsiflexion, improved significantly from −8° ± 5.9° to 11.1° ± 6.7° directly after surgery to 16.2° ± 10.7° at follow-up. The improvement of passive ankle dorsiflexion was significantly associated with the continuous wearing of night and day orthosis (p = 0.0045). Patient subjective satisfaction was very high. Conclusion: A transverse Vulpius procedure for aponeurotic gastrocnemius and soleus muscle lengthening of equinus foot deformity resulted in a significant improvement of passive ankle dorsiflexion. Positive surgical results correlated to a continuous use of orthotic devices.
Blood-Stained Colostrum: A Rare Phenomenon at an Early Lactation Stage
Authors: Katarzyna Wszołek , Małgorzata Pięt , Agata Więckowska (Pająk) , Wioletta Meissner , Jan Mazela , Katarzyna Rybicka , Maciej Wilczak
Published: February 2022

The phenomenon described in the literature as rusty pipe syndrome is a rare condition (the estimated incidence is 0.1% in the population of breastfeeding women) where the prenatal milk and the colostrum are rust- or blood-colored. Due to the rare occurrence of this phenomenon and the related nature of the baby’s regurgitated discharge—green, brown or blood-stained, there is a general fear of latching a newborn or continuing to breastfeed if the regurgitation persists. In this care report, a patient’s milk was tested to determine its microbiological and morphological content. No significant abnormalities were noted in these tests. The nutritional profile of the blood-stained colostrum was normal. Breast milk has an indisputably invaluable impact on the newborn’s further development and there is no connection between rusty pipe syndrome, as described in the literature, and any clinical complications. This is crucial to encourage mothers to keep breastfeeding even if they observe blood-stained colostrum.
Marital Satisfaction, Family Functioning, and Children’s Mental Health—The Effect of Parental Co-Viewing
Authors: Du Xianxian , Liang Mengjiao , Mu Weiqi , Li Fugui , Li Siying , Li Xue , Xu Jie , Wang Kexin , Zhou Mingjie
Published: February 2022

Using 318 household data concerning children during middle childhood (8–13), we examined the association among each parent’s marital satisfaction, the child’s perceived family functioning, and the child’s anxiety and depression. Second, we investigated whether the other parent could buffer or facilitate this chain effect by co-viewing programs via various devices with their child so as to improve the child’s perceived family functioning. Results verified the mediation effect that maternal marital satisfaction was positively associated with the child’s perceived family functioning, which, in turn, decreased the child’s depression. In addition, the results indicated that increased paternal co-viewing enhanced the positive association between maternal marital satisfaction and the child’s perceived family functioning and then decreased the child’s depression. The theoretical and practical implications are discussed within the framework of family systems theory, parental media interventions, and the different roles of the father and mother in family functionality.
Effect of Centralization on Surgical Outcome of Children Operated for Liver Tumors in Switzerland: A Retrospective Comparative Study
Authors: Leoni Jasmine , Rougemont Anne-Laure , Calinescu Ana M. , Ansari Marc , Compagnon Philippe , Wilde Jim C. H. , Wildhaber Barbara E.
Published: February 2022

Background: Pediatric liver surgery is complex, and complications are not uncommon. Centralization of highly specialized surgery has been shown to improve quality of care. In 2012, pediatric liver surgery was centralized in Switzerland in one national center. This study analyses results before and after centralization. Methods: Retrospective monocentric comparative study. Analysis of medical records of children (0–16 years) operated for any liver tumor between 1 January 2001 and 31 December 2020. Forty-one patients were included: 14 before centralization (before 1 January 2012) and 27 after centralization (after 1 January 2012). Epidemiological, pre-, intra-, and post-operative data were collected. Fischer’s exact and t-test were used to compare groups. Results: The two cohorts were homogeneous. Operating time was reduced, although not significantly, from 366 to 277 min. Length of postoperative stay and mortality were not statistically different between groups. Yet, after centralization, overall postoperative complication rate decreased significantly from 57% to 15% (p = 0.01), Clavien > III complications decreased from 50% to 7% (p < 0.01), and hepatic recurrences were also significantly reduced (40% to 5%, p = 0.03). Conclusion: Centralization of the surgical management of liver tumors in Switzerland has improved quality of care in our center by significantly reducing postoperative complications and hepatic recurrence.
The Survivorship Bias in Congenital Diaphragmatic Hernia
Authors: Aydin Emrah , Torlak Nilhan , Haberman Beth , Lim Foong-Yen , Peiro Jose L.
Published: February 2022

Current literature for congenital diaphragmatic hernia (CDH) focuses on the comparison of the overall mortality in CDH patients. Only a few studies concentrate on analyzing the unstable patients who could not achieve surgical repair, as well as those who could but did not survive after. Hence, this study aimed to analyze the effects of various parameters on the timing of death. A retrospective analysis was performed by using the data of all CDH patients from 2003 to 2016 at a single tertiary center. Patients who were diagnosed with left-sided CDH and expired were included in the study regardless of the cause. Of the 66 expired patients, 5 were excluded due to right-sided CDH. The study population constituted a total of 61 patients, of which 31 patients expired prior to CDH repair, and 30 patients expired at different times after CDH repair. Multinomial regression analysis identified that the ECMO need (B = 20.257, p = 0.000, OR: 62.756, 95% CI 10.600–371.384) and O/E LHR (B = 20.376, p = 0.000, OR: 70.663, 95% CI 48.716–102.415) values were the independent predictors that influenced mortality in this cohort. Prenatal pulmonary measurements are the major predictors determining the severity of the disease in patients with CDH.
Hydrometrocolpos in Infants: Etiologies and Clinical Presentations
Authors: Chen Mi-Chi , Chang Yao-Lung , Chao Hsun-Chin
Published: February 2022

Hydrometrocolpos (HMC) is a rare condition where fluids or secretions accumulate in the vagina (hydrocolpos) or up to the uterus (hydrometrocolpos). This case series study reports three infants with different etiologies and presentations of HMC and aims to review literature for proper workup upon initial diagnosis. The first neonate antenatally presented with a huge cystic mass. HMC secondary to imperforate hymen was proved, and hymenotomy was performed at 2 days of age. The second participant presented with persistent urogenital sinus and hematopoietic chimerism, possibly due to transfusion from her twin brother via placenta anastomoses. At 2 months of corrected age, she had difficult defecating, and sonogram revealed HMC with normal appearance of uterus and ovaries. Regular follow-ups and surgical reconstruction will be conducted before puberty. The third patient had cloacal malformation and multiple congenital anomalies at birth. Vesicovaginal fistula-related HMC was detected and managed with surgical drainage in the neonate stage. The girl began menstruation with dysmenorrhea at 12 years. The image studies demonstrated hematometrocolpos secondary to left-side hemivaginal septum, uterine didelphy, and ipsilateral renal agenesis, indicating Herlyn–Werner–Wunderlich syndrome. HMC can be diagnosed easily via sonogram. Careful external genitalia examinations help to identify persistent urogenital sinus or cloacal malformation. Occasionally, the HMC may be part of syndrome manifestations or associated with sex chromosome anomalies. Clinicians may conduct surveillance of renal, cardiac, and skeletal systems as well as chromosome study for early diagnosis and management.
An Analysis of the Links between Smoking and BMI in Adolescents: A Moving Average Approach to Establishing the Statistical Relationship between Quantitative and Dichotomous Variables
Authors: Varaksin Anatoly N. , Konstantinova Ekaterina D. , Maslakova Tatiana A. , Shalaumova Yulia V. , Nasybullina Galia M.
Published: February 2022

The aim of this study was to determine the effect of smoking on BMI in male adolescents and explore the relationship between smoking status and diet. Methods: A cross-sectional epidemiological study into the health and diet of adolescents was carried out based on a representative sample of 375 vocational school male students aged 16–17 in the city of Chelyabinsk (Russian Federation). The students and their parents filled out verified questionnaires on their socioeconomic status, diet, and smoking status. Students’ height and body weight were measured. A comparative analysis of diets was performed between groups of smokers and non-smokers (149 and 226 individuals, respectively), and the relationship between smoking, body mass index, and actual diet was estimated. The methods used included descriptive statistics, Student’s t-test, Mann–Whitney U test, comparison of proportions, and moving average. Results: Non-smoking adolescent boys tended to have excess body mass compared with smokers (19.0% and 12.1%, respectively). Smokers (adolescent boys) consumed less meat, cereals, beans, and cheeses and more sweet beverages, added sugar, coffee, and alcohol. The bulk of the smokers’ diet was composed of carbohydrates (p = 0.026) and, to a lesser extent, proteins (p = 0.006). Conclusions: Significant differences were discovered in the diet between smokers and non-smokers (among adolescent boys), and smoking was associated with several indicators of unhealthy diet patterns. This is an important conclusion for developing a future program that could additionally protect at-risk groups of adolescents.
Evaluation of the Urban Microclimate in Catania Using Multispectral Remote Sensing and GIS Technology
Authors: Mangiameli Michele , Mussumeci Giuseppe , Gagliano Antonio
Published: February 2022

This study focuses on the determination and examination of both the Land Surface Temperature (LST) and the atmospheric temperature in the city of Catania Sicily (Italy), through freely available satellite remote sensing images from the Sentinel-2 and MODIS missions. Satellite images were processed as raster data in free and open-source GIS environments. The GIS software allows the retrieval, processing of the satellite images for the estimation of the LST and the atmospheric temperature with a very coarse spatial resolution. In particular, the proposed procedure allows increasing the spatial resolution of satellite images, from 250 m (LRES) to 10 m (HRES) through the principle of “Disaggregation of thermal images”. The analysis provided georeferenced maps which show the LST, as well as the atmospheric temperature within the investigated area with a very fine resolution, 10 m. Such spatial resolution reveals evident correlations between areas with different urban densities and their microclimate. An important result of this study is that significant LST differences can be observed during both day (15–17 °C) and night (2–3 °C) between green and built-up areas. The outcomes of this study highlight the effectiveness of the combined use of satellite remote sensing and GIS for analyzing the thermal response of urbanized areas with different built density.
Implications of Flood Risk Reduction Interventions on Community Resilience: An Assessment of Community Perception in Bangladesh
Authors: Ansari Md. Sazzad , Warner Jeroen , Sukhwani Vibhas , Shaw Rajib
Published: February 2022

Bangladesh, a flat densely populated country in a dynamic delta, is vulnerable to recurring flood disasters. Various types of structural and non-structural flood risk reduction interventions have been implemented over the years to safeguard the people and assets. In that context, the present study assesses the community perception about the implications of such diverse interventions on community resilience, in three reasonably proximate settlements, with varying characteristics: the Type 1 settlement has a flood protection embankment; the Type 2 settlement has no flood risk reduction intervention, and the Type 3 settlement has non-structural interventions. Through a mixed-method assessment in selected settlements, the study results reveal both positive and negative implications of these interventions on local communities. While the embankment has contributed towards enhancing infrastructural resilience in the Type 1 settlement, it still reportedly does not provide complete flood safety. On the other hand, the non-structural measures are reported to have increased community competencies in the Type 3 settlement, but the long-term sustainability of these traits is uncertain. Furthermore, the study results uncover “connectedness among local communities” as an inherent characteristic in all three locations, whereas flood risk reduction interventions are stated to be partly associated with social tension and the marginalization of certain socio-economic groups.
Study of Turbulence Associated with the Faraji Cyclone
Authors: Ciardullo Giuseppe , Primavera Leonardo , Ferrucci Fabrizio , Carbone Vincenzo , Lepreti Fabio
Published: February 2022

The formation of a cyclonic region in which nonlinear interactions generate turbulence in the form of small-scale vortices can be observed because of the different rotating air masses. Turbulence dynamics in cyclones (specifically hurricanes) has been under-researched; therefore, assessing the shear term is crucial to identify the onset of cyclonic formation within a region of the atmosphere. Earth observation techniques are able to provide relevant information on this physical process. In this article, we propose a new framework that is useful for connecting the study of the dynamics of a cyclonic system with the observations generated by geostationary satellite facilities. In particular, we applied the proper orthogonal decomposition (POD), a technique widely used in turbulent analysis to decompose a generic scalar or vector field in empirical eigenfunction, to investigate a tropical cyclone, the Faraji hurricane, from a dynamic point of view, beginning from the temporal evolution of its temperature field. The latter was obtained by elaborating on data and images collected by the SEVIRI radiometer, installed on the Meteosat Second Generation-8 (IODC) satellite. Using the POD, the energy spectra of both the spatial and temporal components of the temperature field obtained through remote sensing techniques were studied separately. Important information was then extracted and used for an in-depth characterization of the properties of the turbulence in the non-linear evolution of this phenomenon.
Numerical Study of Thermal Radiation Phenomenon and Its Influence on Amelioration of the Heat Transfer Mechanism through MHD Non-Newtonian Casson Model
Authors: Khader Mohamed M. , Babatin Mohammed M. , Megahed Ahmed M.
Published: February 2022

The present study’s main focus is regarding the physical properties of a two-dimensional (2D) magneto-hydrodynamic boundary layer non-Newtonian Casson fluid flow that moves due to an exponentially expanding surface with a mixed convection heat transfer mechanism. In the hydrodynamic flow and heat transmission process, the combined impact of thermal radiation and magnetic field influence is explored. The internal heat generation owing to the fluid motion or a very fluid viscosity is not taken into account. The Chebyshev spectral method (CSM) is employed in this work due to its ability, accuracy, and ease of obtaining the solution for non-linear system of ordinary differential equations (ODEs). This method is an approximate method that can usually obtain the solution in a series form. The mixed convection impact is incorporated in our problem. The results are graphed to help comprehend the many physical parameters that arise in the problem. Graphical results uncover that the speed liquid stream is lessened when reinforcing both the Casson boundary and the Hartmann number, while converse attributes are applied for the Grashof number and the radiation boundary. Finally, a comparison of our current results with previously published work on several particular situations of the problem reveals that they are in excellent agreement.
Improvement of Corrosion Resistance and Biocompatibility of Biodegradable Mg–Ca Alloy by ALD HfZrO2 Film
Authors: Lin Pi-Chen , Lin Kaifan , Lin Yu-Hsuan , Yang Kai-Chiang , Semenov Vladimir Ivanovitch , Lin Hsin-Chih , Chen Miin-Jang
Published: February 2022

Polycrystalline HfZrO2 (HZO) film can be fabricated on as-extruded Mg–Ca alloy, which is identified by the results of XRD and TEM. HZO film can improve the corrosion resistance of as-extruded Mg–Ca alloy to further result in a decrease in the corrosion rate of Mg–Ca alloy. Corrosion current density, pH value evaluation, and the corrosion surface image provide evidence of improvement in corrosion rate. Compared with ZrO2 film, HZO film shows better short-term corrosion resistance. The results of WST-1 assay and LDH assay show that HZO film has low toxicity and is suitable for the protective coating of biological implants.
Extreme Learning Machine Approach to Modeling the Superconducting Critical Temperature of Doped MgB2 Superconductor
Authors: Olatunji Sunday Olusanya , Owolabi Taoreed
Published: February 2022

Magnesium diboride (MgB2) superconductor combines many unique features such as transparency of its grain boundaries to super-current flow, large coherence length, absence of weak links and small anisotropy. Doping is one of the mechanisms for enhancing these features, as well as the superconducting critical temperature, of the compound. During the process of doping, the MgB2 superconductor structural lattice is often distorted while the room temperature resistivity, as well as residual resistivity ratio, contributes to the impurity scattering in the lattice of doped samples. This work develops three extreme learning machine (ELM)-based empirical models for determining MgB2 superconducting critical temperature (TC) using structural distortion as contained in lattice parameters (LP) of doped superconductor, room temperature resistivity (RTR) and residual resistivity ratio (RRR) as descriptors. The developed models are compared with nine different existing models in the literature using different performance metrics and show superior performance over the existing models. The developed SINE-ELM-RTR model performs better than Intikhab et al. (2021)_linear model, Intikhab et al. (2021)_Exponential model, Intikhab et al. (2021)_Quadratic model, HGA-SVR-RRR(2021) model and HGA-SVR-CLD(2021) model with a performance improvement of 32.67%, 29.56%, 20.04%, 8.82% and 13.51%, respectively, on the basis of the coefficient of correlation. The established empirical relationships in this contribution will be of immense significance for quick estimation of the influence of dopants on superconducting transition temperature of MgB2 superconductor without the need for sophisticated equipment while preserving the experimental precision.
Novel Insights into the Immunotherapy-Based Treatment Strategy for Autoimmune Type 1 Diabetes
Authors: Rathod Sanjay
Published: February 2022

Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing pancreatic β-cells by their own immune system, resulting in lifelong insulin deficiency. Continuous exogenous insulin replacement therapy is the current standard of care for T1D. Transplantation of primary pancreatic islets or the entire pancreas is a viable remedy for managing patients with autoimmune T1D. However, this strategy is not feasible due to several obstacles, including a scarcity of donors, islet cells, and poor vascular engraftment of islets post-transplantation, as well as the need for prolonged immune suppression. Innovative approaches must be developed to counteract pancreatic β-cell destruction and salvage endogenic insulin production, thereby regulating blood glucose levels. This review includes an overview of autoimmune T1D, immune cells involved in T1D pathophysiology, and immunotherapy-based strategies to treat and prevent autoimmune T1D. Recent immunotherapy progress toward targeting pancreatic islet-specific immune pathways tangled tolerance has fueled the advancement of therapies that may allow for the prevention or reversal of this autoimmune T1D while avoiding other adverse reactions associated with the previous attempt, which was mostly immunosuppressive. As a result, significant efforts are currently underway to improve the efficacy of immunotherapy-based approaches by leveraging the beneficial actions of immune cells, specifically effector CD4+, CD8+, and regulatory T cells. This review will provide an overview of currently available immune-based therapeutic options for T1D and will examine the growing evidence that supports the use of immune cell-based approaches to improve therapeutic outcomes in the prevention or reversal of autoimmune T1D.
Update on Molecular Diagnosis in Extranodal NK/T-Cell Lymphoma and Its Role in the Era of Personalized Medicine
Authors: Sun Ka-Hei (Murphy) , Wong Yin-Ting (Heylie) , Cheung Ka-Man (Carmen) , Yuen Carmen (Michelle) , Chan Yun-Tat (Ted) , Lai Wing-Yan (Jennifer) , Chao Chun (David) , Fan Wing-Sum (Katie) , Chow Yuen-Kiu (Karen) , Law Man-Fai , Tam Ho-Chi (Tommy)
Published: February 2022

Natural killer (NK)/T-cell lymphoma (NKTCL) is an aggressive malignancy with unique epidemiological, histological, molecular, and clinical characteristics. It occurs in two pathological forms, namely, extranodal NKTCL (ENKTCL) and aggressive NK leukemia, according to the latest World Health Organization (WHO) classification. Epstein–Barr virus (EBV) infection has long been proposed as the major etiology of lymphomagenesis. The adoption of high-throughput sequencing has allowed us to gain more insight into the molecular mechanisms of ENKTCL, which largely involve chromosome deletion and aberrations in Janus kinase (JAK)-signal transducer and activator of transcription (STAT), programmed cell death protein-1 (PD-1)/PD-ligand 1 (PD-L1) pathways, as well as mutations in tumor suppressor genes. The molecular findings could potentially influence the traditional chemoradiotherapy approach, which is known to be associated with significant toxicity. This article will review the latest molecular findings in NKTCL and recent advances in the field of molecular diagnosis in NKTCL. Issues of quality control and technical difficulties will also be discussed, along with future prospects in the molecular diagnosis and treatment of NKTCL.
Novel Magnetic Resonance Imaging Tools for the Diagnosis of Degenerative Disc Disease: A Narrative Review
Authors: Mallio Carlo A. , Vadalà Gianluca , Russo Fabrizio , Bernetti Caterina , Ambrosio Luca , Zobel Bruno Beomonte , Quattrocchi Carlo C. , Papalia Rocco , Denaro Vincenzo
Published: February 2022

Low back pain (LBP) is one of the leading causes of disability worldwide, with a significant socioeconomic burden on healthcare systems. It is mainly caused by degenerative disc disease (DDD), a progressive, chronic, and age-related process. With its capacity to accurately characterize intervertebral disc (IVD) and spinal morphology, magnetic resonance imaging (MRI) has been established as one of the most valuable tools in diagnosing DDD. However, existing technology cannot detect subtle changes in IVD tissue composition and cell metabolism. In this review, we summarized the state of the art regarding innovative quantitative MRI modalities that have shown the capacity to discriminate and quantify changes in matrix composition and integrity, as well as biomechanical changes in the early stages of DDD. Validation and implementation of this new technology in the clinical setting will allow for an early diagnosis of DDD and ideally guide conservative and regenerative treatments that may prevent the progression of the degenerative process rather than intervene at the latest stages of the disease.
Prediction of Recurrent Urinary Tract Infection in Paediatric Patients by Deep Learning Analysis of 99mTc-DMSA Renal Scan
Authors: Lee Hyunjong , Yoo Beongwoo , Baek Minki , Choi Joon Young
Published: February 2022

Purpose: Tc-99m dimercaptosuccinic acid (99mTc-DMSA) renal scan is an important tool for the assessment of childhood urinary tract infection (UTI), vesicoureteral reflux (VUR), and renal scarring. We evaluated whether a deep learning (DL) analysis of 99mTc-DMSA renal scans could predict the recurrence of UTI better than conventional clinical factors. Methods: the subjects were 180 paediatric patients diagnosed with UTI, who underwent immediate post-therapeutic 99mTc-DMSA renal scans. The primary outcome was the recurrence of UTI during the follow-up period. For the DL analysis, a convolutional neural network (CNN) model was used. Age, sex, the presence of VUR, the presence of cortical defects on the 99mTc-DMSA renal scan, split renal function (SRF), and DL prediction results were used as independent factors for predicting recurrent UTI. The diagnostic accuracy for predicting recurrent UTI was statistically compared between independent factors. Results: The sensitivity, specificity and accuracy for predicting recurrent UTI were 44.4%, 88.9%, and 82.2% by the presence of VUR; 44.4%, 76.5%, and 71.7% by the presence of cortical defect; 74.1%, 80.4%, and 79.4% by SRF (optimal cut-off = 45.93%); and 70.4%, 94.8%, and 91.1% by the DL prediction results. There were no significant differences in sensitivity between all independent factors (p > 0.05, for all). The specificity and accuracy of the DL prediction results were significantly higher than those of the other factors. Conclusion: DL analysis of 99mTc-DMSA renal scans may be useful for predicting recurrent UTI in paediatric patients. It is an efficient supportive tool to predict poor prognosis without visually demonstrable cortical defects in 99mTc-DMSA renal scans.
Robust Hierarchical Formation Control of Unmanned Aerial Vehicles via Neural-Based Observers
Authors: Fei Yang , Sun Yuan , Shi Peng
Published: February 2022

Herein, we investigate the robust formation control problem for a group of unmanned aerial vehicles (UAVs) with system uncertainty. A hierarchical formation control strategy is introduced to ensure the uniform ultimate boundedness of each UAV’s reference tracking error. First, a group of saturated high-level virtual agents are defined to act as the trajectory planners that offer feasible position references to the actual UAVs. A sliding mode neural-based observer is then constructed to estimate the nonlinear uncertainty in the UAV model. Furthermore, sliding mode controllers are designed for both the position loop and the attitude loop of the UAV. To attenuate the chattering phenomenon in the control input, a saturated and smoothed differentiator is proposed along with an observation introduction function. The effectiveness of the proposed control scheme is validated by both the Lyapunov stability theory and numerical simulations based on a multiple-UAV system.
State-of-Art Review of Traffic Light Synchronization for Intelligent Vehicles: Current Status, Challenges, and Emerging Trends
Authors: Tomar Ishu , Sreedevi Indu , Pandey Neeta
Published: February 2022

The effective control and management of traffic at intersections is a challenging issue in the transportation system. Various traffic signal management systems have been developed to improve the real-time traffic flow at junctions, but none of them have resulted in a smooth and continuous traffic flow for dealing with congestion at road intersections. Notwithstanding, the procedure of synchronizing traffic signals at nearby intersections is complicated due to numerous borders. In traditional systems, the direction of movement of vehicles, the variation in automobile traffic over time, accidents, the passing of emergency vehicles, and pedestrian crossings are not considered. Therefore, synchronizing the signals over the specific route cannot be addressed. This article explores the key role of real-time traffic signal control (TSC) technology in managing congestion at road junctions within smart cities. In addition, this article provides an insightful discussion on several traffic light synchronization research papers to highlight the practicability of networking of traffic signals of an area. It examines the benefits of synchronizing the traffic signals on various busy routes for the smooth flow of traffic at intersections.
Python-Based TinyIPFIX in Wireless Sensor Networks
Authors: Schiller Eryk , Huber Ramon , Stiller Burkhard
Published: February 2022

While wireless sensor networks (WSN) offer potential, their limited programmability and energy limitations determine operational challenges. Thus, a TinyIPFIX-based system was designed such that this application layer protocol is now used to exchange data in WSNs efficiently. The new prototype is based on the Espressif ESP32-WROOM-32D Internet-of-Things (IoT) platform, which is becoming famous, as it is inexpensive but powerful compared to older generations of IoT devices. The system implementation is provided in the programming language MicroPython, which provides a simple and efficient implementation, compared to a lower-level programming language. Therefore, this approach focuses on value creation rather than platform-specific implementation difficulties. The system is evaluated in smart home use cases and displays valuable overhead, reliability, and power efficiency. TinyIPFIX outperforms the data overhead of the type–length–value (TLV) paradigm by a factor of 7% when a TinyIPFIX data message carries only two records, and one TinyIPFIX template message is sent per three TinyIPFIX data messages. A further decrease in overhead is observed when the number of data records per message and the number of TinyIPFIX data messages sent per one TinyIPFIX template message increase to larger values. The message delivery between end devices and the application server resides at a very high level, close to 100%, when the transmission reliability is secured with acknowledgments and retransmissions. The energy efficiency resides at the limited level, as the experienced deep sleep power consumption of the ESP32 device resides at the milliwatt level.
A Multi-Slot Two-Antenna MIMO with High Isolation for Sub-6 GHz 5G/IEEE802.11ac/ax/C-Band/X-Band Wireless and Satellite Applications
Authors: Alharbi Abdullah G. , Kulkarni Jayshri , Desai Arpan , Sim Chow-Yen-Desmond , Poddar Ajay
Published: February 2022

A tapered symmetrical coplanar waveguide (S-CPW) fed monopole antenna is initially studied. To achieve multiband characteristics, the radiating element of this monopole antenna is loaded with multiple narrow slots and multiple slotted stubs (MSS). The designed slot-loading monopole is further transformed into a two-antenna MIMO type with a gap distance of only 0.12λ (at 5 GHz), and thus it has a small overall size of 32 × 20 × 0.8 mm3. By deploying five concentric ring elements between the two adjacent antenna elements, the desirable isolation of better than 20 dB is yielded. As the low band and high band operation of the proposed two-antenna MIMO is 81.08% (3.3–7.8 GHz) and 40% (8.0–12.0 GHz), respectively, it can therefore satisfy the Sub-6 GHz 5G New Radio (NR) n77/78/79, IEEE 802.11ac/ax, X-band/C-band wireless and satellite applications. Furthermore, it has shown a desirable gain of above 3 dBi and a radiation efficiency greater than 69% throughout the two bands of interest.
Energy Efficiency and Throughput Maximization Using Millimeter Waves–Microwaves HetNets
Authors: Jamil Sonain , Rahman MuhibUr , Tanveer Jawad , Haider Amir
Published: February 2022

The deployment of millimeter waves can fulfil the stringent requirements of high bandwidth and high energy efficiency in fifth generation (5G) networks. Still, millimeter waves communication is challenging because it requires line of sight (LOS). The heterogeneous network (HetNet) of millimeter waves and microwaves solves this problem. This paper proposes a millimeter -microwaves heterogeneous HetNet deployed in an indoor factory (InF). In InF, the manufacturing and production are performed inside big and small halls. We consider non standalone dual-mode base stations (DMBS) working on millimeter waves and microwaves. We analyze the network in terms of throughput and energy efficiency (EE). We formulate mixed-integer-non-linear-programming (MINLP) to maximize the throughput and EE of the network. The formulated problem is a complex optimization problem and hard to solve with exhaustive search. We propose a novel outer approximation algorithm (OAA) to solve this problem, and the proposed algorithm OAA achieves optimal solution at β = 10−3. At this β, the average throughput value obtained is approximately 50 Mbps, whereas the value of EE is 4.4 Mbits/J. We also compare the performance of OAA with the mesh-adaptive-direct-search-algorithm (NOMAD), and the experimental results verify that OAA outperforms NOMAD in terms of throughput and EE maximization. We also compare the performance of OAA with particle swarm optimization (PSO), genetic algorithm (GA), and many others optimization algorithms. Experimental results verify that OAA outperforms all other algorithms.
An Optimization Framework for the Design of High-Speed PCB VIAs
Authors: Avitabile Gianfranco , Florio Antonello , Gallo Vito Leonardo , Pali Alessandro , Forni Lorenzo
Published: February 2022

Signal integrity represents a key issue in all modern electronic systems, which are strongly dominated by the extreme component density usually employed on PCBs and the associated increase in the interconnection density. The use of multi-layer structures with microstrips connected by various types of Vertical Interconnect Accesses (VIAs) calls for design strategies that reduce the impedance mismatch and signal attenuation. The paper proposes a thorough analysis of the effects associated with the VIA geometry and presents a parametric evaluation of them. The obtained results represent the starting point for a possible design procedure that manages the geometric aspects of differential VIAs, aiming to optimize their electrical performance while reducing their occupation of PCB area. The optimization technique considers a differential VIA as a four-port circuit whose characteristics are evaluated with suitable Figures of Merit (FoMs), thus striving for an optimal design obtained with closed-loop iterations. The analysis is performed in both the time (TDR: Time-Domain Reflectometry) and frequency domains (S and Z parameters), thus allowing a dramatic reduction in the number of cases to be analyzed. The procedure is thoroughly described and validated using simulation results.
Effect of Dielectric Thickness on Resistive Switching Polarity in TiN/Ti/HfO2/Pt Stacks
Authors: Vinuesa Guillermo , García Héctor , González Mireia B. , Kalam Kristjan , Zabala Miguel , Tarre Aivar , Kukli Kaupo , Tamm Aile , Campabadal Francesca , Jiménez Juan , Castán Helena , Dueñas Salvador
Published: February 2022

In recent years, several materials and metal-insulator-metal devices are being intensively studied as prospective non-volatile memories due to their resistive switching effect. In this work, thickness-dependent resistive switching polarity was observed in TiN/Ti/HfO2/Pt structures as the sign of the voltages at which SET and RESET occur depended on the film thickness. A thorough revision of the previous literature on bipolar resistive switching polarity changes is made in order to condense previous knowledge of the subject in a brief and comprehensible way and explain the experimental measurements. The different resistive switching polarities occur in a similar voltage range, which is a new finding when compared to precedent research on the subject. A hypothesis is proposed to explain the change in resistive switching polarity, based on the assumption that polarity change is due to filament disruption occurring at different interfaces.
A Non-Isolated Hybrid Zeta Converter with a High Voltage Gain and Reduced Size of Components
Authors: Santosh Kumar Reddy Padala Lakshmi , Obulesu Yeddula Pedda , Singirikonda Srinivas , Al Harthi Mosleh , Alzaidi Mohammed S. , Ghoneim Sherif S. M.
Published: February 2022

In this paper a novel non-coupled inductor-based hybrid Zeta converter with a minimal duty cycle is proposed. The converter’s potential benefits include buck and boost operation modes, easy implementation, continuous input current, and high efficiency. The converter provides a higher voltage gain than a conventional Zeta converter and is adapted to EV and LED applications due to the continuous input current. The proposed converter operates in three distinct operation modes via two electronic switches, each operated independently with a different duty ratio. This paper also analyzes the converter’s performance based on equivalent circuits, and analytical waveforms in each operating mode and design procedure are shown. The voltage gain and dynamic modelling are computed for both buck and boost operational modes for the hybrid Zeta converter. The efficiency and performance of the converter in both operating modes are validated using MATLAB/Simulink. Hardware in the loop (HIL) testing method on RT-LAB OP-5700 for both operation modes of the converter are performed. The peak efficiency of the proposed converter with an input voltage of 36 V is obtained at 95.2%. The proposed converter offers a wide voltage gain at a small duty cycle with fewer components and high efficiency. Simulations and experiments have been carried out under different conditions and the results proved that the proposed converter is a viable solution.
Overview and Assessment of HVDC Current Applications and Future Trends
Authors: Stan Andrei , Costinaș Sorina , Ion Georgiana
Published: February 2022

High voltage direct current (HVDC) technology has begun to gather a high degree of interest in the last few decades, showing a fast evolution of achievable voltage levels, transfer capacities, and transmission lengths. All these changes occurred in a context in which power system applications are highly dependent on HVDC technologies such as energy generation from renewable sources (e.g., energy generated in offshore wind power plants), power exchanges between asynchronous networks, submarine cables, and long-length transmission overhead lines have become more common worldwide. This paper tries to summarize the current state of HVDC technologies, both voltage-source converters and current-source converters, the main components of converter substations, control strategies, key challenges arising from their use, as well as the future prospects and trends of HVDC applications. This paper represents the first step in setting the background information for analyzing the impact of a VSC-HVDC connection on the stability of the Romanian transmission network during steady-state and dynamic operation.
Controlling the Formation of Foams in Broth to Promote the Co-Production of Microbial Oil and Exopolysaccharide in Fed-Batch Fermentation
Authors: Guo Yan-Feng , Wang Meng-Qi , Wang Yi-Lei , Wang Hong-Tao , Xu Jian-Zhong
Published: February 2022

A large amount of foam is generated in the production of microbial oil and exopolysaccharide (EPS) by Sporidiobolus pararoseus JD-2, which causes low efficiency in fermentation. In this study, we aimed to reduce the negative effects of foams on the co-production of oil and EPS by controlling the formation of foams in broth. As we have found, the formation of foams is positively associated with cell growth state, air entrapment, and properties of broth. The efficient foam-control method of adding 0.03% (v/v) of the emulsified polyoxyethylene polyoxypropylene pentaerythritol ether (PPE) and feeding corn steep liquor (CSL) at 8–24 h with speed of 0.02 L/h considerably improved the fermentation performance of S. pararoseus JD-2, and significantly increased the oil and EPS concentrations by 8.7% and 12.9%, respectively. The biomass, oil, and EPS concentrations were further increased using a foam backflow device combined with adding 0.03% (v/v) of the emulsified PPE and feeding CSL at 8–24 h, which reached to 62.3 ± 1.8 g/L, 31.2 ± 0.8 g/L, and 10.9 ± 0.4 g/L, respectively. The effective strategy for controlling the formation of foams in fermentation broth reported here could be used as a technical reference for producing frothing products in fed-batch fermentation.
Age and Growth of Quillback Rockfish (Sebastes maliger) at High Latitude
Authors: Christoffersen Camron J. , Shiozawa Dennis K. , Suchomel Andrew D. , Belk Mark C.
Published: February 2022

Data on age and growth of fishes is critical for effective management; however, growth rates documented in one location may not be representative of other locations, especially for species that occur across wide geographic ranges. Sebastes maliger, quillback rockfish, occur across a broad latitudinal range, but their growth patterns have been quantified only in the southern part of their range. To provide information for S. maliger in the more northern part of its range, we report age and growth patterns derived from otolith analysis from a population collected in southeast Alaskan waters. In southeast Alaska mean annual growth increments for years 1 and 2 range from 60–80 mm, and for ages 6–9 annual growth increments average about 20 mm. From age 10 on average the annual growth increment is about 5 mm. These data can be used in conjunction with harvest data to manage stocks of S. maliger in Alaskan waters.
Drag Reduction of Turbulent Boundary Layers by Travelling and Non-Travelling Waves of Spanwise Wall Oscillations
Authors: Skote Martin
Published: February 2022

Turbulence control in the form of a streamwise travelling wave of transverse wall motion was studied numerically by employing direct numerical simulations (DNS). Both total and phase averaging were utilised to examine the statistical behaviour of the turbulence affected by the wall forcing, with a focus on the skin friction. Comparison with results from pure temporal and spatial wall forcing are conducted, and a compilation of data is used to explore analogies with drag-reduced channel flow.
Sublethal Damage to Erythrocytes during Blood Flow
Authors: Avcı Mesude , O’Rear Edgar A. , Foster Kylie M. , Papavassiliou Dimitrios V.
Published: February 2022

Mechanical circulatory support (MCS) devices are designed to perform the functional needs of organs and to meet clinical hemocompability criteria. Critical complications have been reported with their long-term use such as thrombosis, anemia and gastrointestinal bleeding. Damage to red blood cells (RBCs), which occurs with nonphysiological blood flow conditions such as contact with foreign surfaces, high shear stress, and turbulence, is a major problem for the design and development of these systems. Even in the absence of hemolysis, cardiovascular devices (CAD) still cause cell injury and shortened RBC lifespans. This review summarizes various effects that occur to erythrocytes exposed to supraphysiological but sublethal stresses.
The Quantification of IgG Specific to α-Gal Could Be Used as a Risk Marker for Suffering Mammalian Meat Allergy
Authors: Joral Alejandro , Azketa Nahikari , Sanchez Patricia , Vélez-del-Burgo Ainara , Aranzabal-Soto María-Ascensión , Lizarza Susana , Martínez Jorge , Postigo Idoia
Published: February 2022

The alpha-Gal Syndrome is a delayed meat allergy characterized by the presence of sIgE against α-Gal epitope. It is known that the α-Gal present in tick saliva induces the sensitization to this epitope ending in the production of sIgG and sIgE to α-Gal. It could be considered that the more times a person is bitten by tick species, the higher the probability of making the switch from sIgG to sIgE to α-Gal and developing allergy, but it is no clear when the switch occurs. To determine the likelihood that a subject bitten by ticks but without AGS be at risk of developing this allergy, we quantified the levels of sIgG to α-Gal by an automated system (ImmunoCap). To stablish a cut-off value for sIgG to α-Gal, a receiving operating curve (ROC) was constructed. The statistical analysis demonstrated that the risk of suffering AGS in individuals bitten by ticks was 35% when the sIgG to α-Gal was greater than or equal to 40 µg/mL. Our data indicate that the sIgG values against α-Gal could be used as a prognostic marker for developing mammalian meat allergy.