bluuebunny/crossref_metadata_2025 huggingface dataset:
Human Placenta Mesenchymal Stem Cell Protection in Ischemic Stroke is Angiotensin Converting Enzyme-2 and Masr Receptor-Dependent
Authors: Barzegar Mansoureh , Vital Shantel , Stokes Karen Y. , Wang Yuping , Yun Jungmi Winny , White Luke A. , Chernyshev Oleg , Kelley Roger E. , Alexander Jonathan S.
Published: November 2021

Thromboembolic stroke remains a major cause of neurological disability and death. Current stroke treatments (aspirin, tissue plasminogen activator) are significantly limited by timing and risks for hemorrhage which have driven researchers to explore other approaches. Stem cell-based therapy appears to be an effective option for ischemic stroke. Besides trans-differentiation into neural cells, stem cells also provide acute protection via paracrine signaling pathways through which releasing neuroprotective factors. We previously reported that intraperitoneal administration of human placenta mesenchymal stem cell (hPMSC) therapy upon reperfusion significantly protected the brain against middle cerebral artery occlusion (MCAO)-induced injury. In the present study, we specifically investigated the role of hPMSC-derived angiotensin converting enzyme-2 (ACE-2) in protection of MCAO-induced brain injury by measurement of brain tissue viability, cerebral blood flow, and neurological score. Here, we report for the first time that hPMSC expressing substantial amount of ACE-2, which mediates hPMSC protection in the MCAO model. Strikingly, we found that the protective effects of hPMSC in MCAO-induced brain injury could be attenuated by pretreatment of hPMSCs with MLN-4760, a specific inhibitor of ACE-2 activity, or by transfection of hPMSCs with ACE-2-shRNA-lentivirus. The hPMSC-derived ACE-2 specific protective mechanism was further demonstrated by administration of PD123319, an Angiotensin type-2 receptor antagonist, or A779, a MasR antagonist. Importantly, our study demonstrated that the protective effects of hPMSC in experimental stroke are ACE-2/MasR dependent and this signaling pathway represents an innovative and highly promising approach for targeted stroke therapy.
Transient Receptor Potential Vanilloid 4 as a Regulator of Induced Pluripotent Stem Cell Chondrogenesis
Authors: Willard Vincent P. , Leddy Holly A. , Palmer Daniel , Wu Chia-Lung , Liedtke Wolfgang , Guilak Farshid
Published: November 2021

Transient receptor potential vanilloid 4 (TRPV4) is a polymodal calcium-permeable cation channel that is highly expressed in cartilage and is sensitive to a variety of extracellular stimuli. The expression of this channel has been associated with the process of chondrogenesis in adult stem cells as well as several cell lines. Here, we used a chondrogenic reporter (Col2a1-GFP) in murine induced pluripotent stem cells (iPSCs) to examine the hypothesis that TRPV4 serves as both a marker and a regulator of chondrogenesis. Over 21 days of chondrogenesis, iPSCs showed significant increases in Trpv4 expression along with the standard chondrogenic gene markers Sox9, Acan, and Col2a1, particularly in the green fluorescent protein positive (GFP+) chondroprogenitor subpopulation. Increased gene expression for Trpv4 was also reflected by the presence of TRPV4 protein and functional Ca2+ signaling. Daily activation of TRPV4 using the specific agonist GSK1016790A resulted in significant increases in cartilaginous matrix production. An improved understanding of the role of TRPV4 in chondrogenesis may provide new insights into the development of new therapeutic approaches for diseases of cartilage, such as osteoarthritis, or channelopathies and hereditary disorders that affect cartilage during development. Harnessing the role of TRPV4 in chondrogenesis may also provide a novel approach for accelerating stem cell differentiation in functional tissue engineering of cartilage replacements for joint repair.
Three-Dimensional Migration of Human Amniotic Fluid Stem Cells Involves Mesenchymal and Amoeboid Modes and is Regulated by mTORC1
Authors: Rosner Margit , Hengstschläger Markus
Published: November 2021

Three-dimensional (3D) cell migration is an integral part of many physiologic processes. Although being well studied in the context of adult tissue homeostasis and cancer development, remarkably little is known about the invasive behavior of human stem cells. Using two different kinds of invasion assays, this study aimed at investigating and characterizing the 3D migratory capacity of human amniotic fluid stem cells (hAFSCs), a well-established fetal stem cell type. Eight hAFSC lines were found to harbor pronounced potential to penetrate basement membrane (BM)-like matrices. Morphological examination and inhibitor approaches revealed that 3D migration of hAFSCs involves both the matrix metalloprotease-dependent mesenchymal, elongated mode and the Rho-associated protein kinase-dependent amoeboid, round mode. Moreover, hAFSCs could be shown to harbor transendothelial migration capacity and to exhibit a motility-associated marker expression pattern. Finally, the potential to cross extracellular matrix was found to be induced by mTORC1-activating growth factors and reduced by blocking mTORC1 activity. Taken together, this report provides the first demonstration that human stem cells exhibit mTORC1-dependent invasive capacity and can concurrently make use of mesenchymal and amoeboid 3D cell migration modes, which represents an important step toward the full biological characterization of fetal human stem cells with relevance to both developmental research and stem cell-based therapy.
Bidirectional Relationship Between Cardiac Extracellular Matrix and Cardiac Cells in Ischemic Heart Disease
Authors: Park Hyun-Ji , De Jesus Morales Kenneth J. , Bheri Sruti , Kassouf Brandon P. , Davis Michael E.
Published: November 2021

Ischemic heart diseases (IHDs), including myocardial infarction and cardiomyopathies, are a leading cause of mortality and morbidity worldwide. Cardiac-derived stem and progenitor cells have shown promise as a therapeutic for IHD but are limited by poor cell survival, limited retention, and rapid washout. One mechanism to address this is to encapsulate the cells in a matrix or three-dimensional construct, so as to provide structural support and better mimic the cells' physiological microenvironment during administration. More specifically, the extracellular matrix (ECM), the native cellular support network, has been a strong candidate for this purpose. Moreover, there is a strong consensus that the ECM and its residing cells, including cardiac stem cells, have a constant interplay in response to tissue development, aging, disease progression, and repair. When externally stimulated, the cells and ECM work together to mutually maintain the local homeostasis by initially altering the ECM composition and stiffness, which in turn alters the cellular response and behavior. Given this constant interplay, understanding the mechanism of bidirectional cell-ECM interaction is essential to develop better cell implantation matrices to enhance cell engraftment and cardiac tissue repair. This review summarizes current understanding in the field, elucidating the signaling mechanisms between cardiac ECM and residing cells in response to IHD onset. Furthermore, this review highlights recent advances in native ECM-mimicking cardiac matrices as a platform for modulating cardiac cell behavior and inducing cardiac repair.
Human Induced Pluripotent Stem Cell-Derived Macrophages Ameliorate Liver Fibrosis
Authors: Pouyanfard Somayeh , Meshgin Nairika , Cruz Luisjesus S. , Diggle Karin , Hashemi Hamidreza , Pham Timothy V. , Fierro Manuel , Tamayo Pablo , Fanjul Andrea , Kisseleva Tatiana , Kaufman Dan S.
Published: November 2021

With an increasing number of patients with degenerative hepatic diseases, such as liver fibrosis, and a limited supply of donor organs, there is an unmet need for therapies that can repair or regenerate damaged liver tissue. Treatment with macrophages that are capable of phagocytosis and anti-inflammatory activities such as secretion of matrix metalloproteinases (MMPs) provide an attractive cellular therapy approach. Human induced pluripotent stem cells (iPSCs) are capable of efficiently generating a large-scale, homogenous population of human macrophages using fully defined feeder- and serum-free differentiation protocol. Human iPSC-macrophages exhibit classical surface cell markers and phagocytic activity similar to peripheral blood-derived macrophages. Moreover, gene and cytokine expression analysis reveal that these macrophages can be efficiently polarized to pro-inflammatory M1 or anti-inflammatory M2 phenotypes in presence of LPS + IFN-γ and IL-4 + IL-13, respectively. M1 macrophages express high level of CD80, TNF-α, and IL-6 while M2 macrophages show elevated expression of CD206, CCL17, and CCL22. Here, we demonstrate that treatment of liver fibrosis with both human iPSC-derived macrophage populations and especially M2 subtype significantly reduces fibrogenic gene expression and disease associated histological markers including Sirius Red, αSMA and desmin in immunodeficient Rag2−/−γc−/− mice model, making this approach a promising cell-based avenue to ameliorate fibrosis.
The Cyclin-Like Protein SPY1 Overrides Reprogramming Induced Senescence Through EZH2 Mediated H3K27me3
Authors: Lubanska Dorota , Qemo Ingrid , Byrne Megan , Matthews Kaitlyn N. , Fifield Bre-Anne , Brown Jillian , Silva Elizabeth Fidalgo , Porter Lisa A.
Published: November 2021

Fully differentiated cells can be reprogrammed through ectopic expression of key transcription factors to create induced pluripotent stem cells. These cells share many characteristics of normal embryonic stem cells and have great promise in disease modeling and regenerative medicine. The process of remodeling has its limitations, including a very low efficiency due to the upregulation of many antiproliferative genes, including cyclin dependent kinase inhibitors CDKN1A and CDKN2A, which serve to protect the cell by inducing apoptotic and senescent programs. Our data reveals a unique cell cycle mechanism enabling mouse fibroblasts to repress cyclin dependent kinase inhibitors through the activation of the epigenetic regulator EZH2 by a cyclin-like protein SPY1. This data reveals that the SPY1 protein is required for reprogramming to a pluripotent state and is capable of increasing reprogramming efficiency.
Tropical fans, scattering equations and amplitudes
Authors: Drummond James , Foster Jack , Gürdoğan Ömer , Kalousios Chrysostomos
Published: November 2021

Abstract

We describe a family of tropical fans related to Grassmannian cluster algebras. These fans are related to the kinematic space of massless scattering processes in a number of ways. For each fan associated to the Grassmannian Gr(k, n) there is a notion of a generalised ϕ3 amplitude and an associated set of scattering equations which further generalise the Gr(k, n) scattering equations that have been recently introduced. Here we focus mostly on the cases related to finite Grassmannian cluster algebras and we explain how face variables for the cluster polytopes are simply related to the scattering equations. For the Grassmannians Gr(4, n) the tropical fans we describe are related to the singularities (or symbol letters) of loop amplitudes in planar $$ \mathcal{N} $$
N
= 4 super Yang-Mills theory. We show how each choice of tropical fan leads to a natural class of polylogarithms, generalising the notion of cluster adjacency and we describe how the currently known loop data fit into this classification.
Maximally dissipative solutions for incompressible fluid dynamics
Authors: Lasarzik Robert
Published: November 2021

We introduce the new concept of maximally dissipative solutions for a general class of isothermal GENERIC systems. Under certain assumptions, we show that maximally dissipative solutions are well-posed as long as the bigger class of dissipative solutions is non-empty. Applying this result to the Navier–Stokes and Euler equations, we infer global well-posedness of maximally dissipative solutions for these systems. The concept of maximally dissipative solutions coincides with the concept of weak solutions as long as the weak solutions inherits enough regularity to be unique.
Mental distress among young adults in Great Britain: long-term trends and early changes during the COVID-19 pandemic
Authors: Gagné T. , Schoon I. , McMunn A. , Sacker A.
Published: November 2021

Purpose

In Great Britain, few studies documented mental health trends in young adults in the years preceding 2020, the mental health dimensions affected, and how these compare with changes observed during the COVID-19 pandemic.

Methods

Long-term trends in mental health among 16–34 year old men and women between 1991 and 2018, and changes between 2018–19 and July–September 2020 were examined using all waves from the British Household Panel Study (1991–2008), the UK Household Longitudinal Study (2009–20), and the first five UKHLS COVID-19 waves administered in April, May, June, July, and September 2020. Findings are based on the GHQ-12 continuous score (0–36), clinically significant cases (4 + /12) and severe cases (7 + /12) for mental distress, and item endorsements.

Results

Between 1991 and 2018, the prevalence of cases (4 + /12) increased from 14–22% to 19–32% across groups. Increases were largest in women aged 16–24. In April 2020, the risk of caseness (4 + /12) increased across groups by 55% to 80% compared to the 2018–19 baseline. This increase, however, rapidly diminished over time: in July–September 2020, there was only a higher risk of caseness (4 + /12) in men aged 25–34 (prevalence ratio = 1.29, 95% CI 1.01–1.65) compared to the 2018–19 baseline.

Conclusion

Whereas distress surged in April 2020, its return to pre-pandemic levels by September 2020 highlights the nuanced impact that the pandemic may have over time. Given the magnitude of the decline in mental health over the past decade, attention must be given to young adults once the pandemic ends.
Social Machines
Authors: Draude Claude , Gruhl Christian , Hornung Gerrit , Kropf Jonathan , Lamla Jörn , Leimeister Jan Marco , Sick Bernhard , Stumme Gerd
Published: November 2021

Social Machines sind ein Paradigma für die Gestaltung soziotechnischer Systeme, die unter Verwendung von Web- und Plattformlösungen das Potenzial digitaler Technologien mit der Eigenlogik sozialer Interaktion, Organisation und Strukturbildung auf neue Weise zusammenführen. Im Folgenden diskutieren wir das Paradigma der Social Machine aus den Perspektiven der Informatik, der Wirtschaftsinformatik, der Soziologie und des Rechts, um Orientierungspunkte für seine Gestaltung zu identifizieren. Der Begriff ist in der Literatur jedoch bisher nicht abschließend definiert sondern nur durch Beispiele illustriert.

In diesem Artikel stellen wir zunächst die folgende Definition zur Diskussion: Social Machines sind soziotechnische Systeme, in denen die Prozesse sozialer Interaktion hybrid zwischen menschlichen und maschinellen Akteuren ablaufen und teilweise algorithmisiert sind. Im Anschluss beleuchten wir drei aktuelle, sich gegenseitig bedingende Entwicklungen von Social Machines: die immer stärkere Verschmelzung von Sozialität und Maschine, die Vermessung von Nutzeraktivitäten als Grundstoff gesellschaftlichen Zusammenhalts und die zunehmende Algorithmisierung gesellschaftlicher Prozesse. Abschließend diskutieren wir, dass eine teilhabeorientierte, demokratischen Werten folgende Gestaltung von Social Machines die Perspektiven der Nutzungsakzeptanz, der gesellschaftlichen Akzeptabilität und der nachhaltigen Wirtschaftlichkeit adressieren und umsetzen muss.
Electrochemical deposition of nickel from aqueous electrolytic baths prepared by dissolution of metallic powder
Authors: Próchniak M. , Grdeń M.
Published: November 2021

A new method of preparation of aqueous electrolyte baths for electrochemical deposition of nickel targets for medical accelerators is presented. It starts with fast dissolution of metallic Ni powder in a HNO3-free solvent. Such obtained raw solution does not require additional treatment aimed to removal nitrates, such as the acid evaporation and Ni salt precipitation-dissolution. It is used directly for preparation of the nickel plating baths after dilution with water, setting up pH value and after possible addition of H3BO3. The pH of the baths ranges from alkaline to acidic. Deposition of 95% of ca. 50 mg of Ni dissolved in the bath takes ca. 3.5 h for the alkaline electrolyte while for the acidic solution it requires ca. 7 h. The Ni deposits obtained from the acidic bath are physically and chemically more stable and possess smoother and crack-free surfaces as compared to the coatings deposited from the alkaline bath. A method of estimation of concentration of H2O2in the electrolytic bath is also proposed.
Prerequisites and initial developments for economic specialization in lagging regions—A study of specialized villages in Iran
Authors: Ghorbani Masoumeh , Brenner Thomas
Published: November 2021

Although the literature provides a huge number of studies on specialized regions, such as clusters and industrial districts, most of them concern developed regions. Studies that focus on the initial processes and preconditions for the emergence of economic specialization in lagging regions are rare, and studies of this kind considering a large number of cases not existing. We use the information on 140 villages in lagging rural regions in Iran to examine the initializing processes and preconditions as well as the connection between the two. We find that the conditions that are present in the region affect the potential initial processes and developments that might lead to specialization. Thus, the findings support the application of place-based policies.
Orthogonal Polynomials on Planar Cubic Curves
Authors: Fasondini Marco , Olver Sheehan , Xu Yuan
Published: November 2021

Orthogonal polynomials in two variables on cubic curves are considered. For an integral with respect to an appropriate weight function defined on a cubic curve, an explicit basis of orthogonal polynomials is constructed in terms of two families of orthogonal polynomials in one variable. We show that these orthogonal polynomials can be used to approximate functions with cubic and square root singularities, and demonstrate their usage for solving differential equations with singular solutions.
Understanding Early Mathematical Modelling: First Steps in the Process of Translation Between Real-world Contexts and Mathematics
Authors: Alsina Ángel , Salgado María
Published: November 2021

The aim of this study is to provide data to better understand the processes of early mathematical modelling. According to this, an early mathematical modelling activity carried out by 21 Spanish schoolchildren aged 5–6 years is analysed, using the validated tool “Rubric for the Evaluation of Mathematical Modelling Processes” (REMMP). The results show that children link the content of the problem with their prior knowledge (understanding); identify the important data of the problem and simplify it (structuring); show some difficulties in substituting the elements of the real context for mathematical objects (mathematizing); use progressively mathematical objects and strategies in order to propose solutions for the problem (working mathematically); compare the solution with the initial problem (interpretation); justify the proposed model via valid arguments (validation); and also communicate the decisions taken throughout the modelling process and the concrete model obtained applied to the real context (presenting). We conclude that the description of this type of activities and the tools for their analysis could be used for grading and teaching tool in order to promote mathematic modelling in early childhood education.
Dynamical System Related to Primal–Dual Splitting Projection Methods
Authors: Bednarczuk E. M. , Dhara R. N. , Rutkowski K. E.
Published: November 2021

We introduce a dynamical system to the problem of finding zeros of the sum of two maximally monotone operators. We investigate the existence, uniqueness and extendability of solutions to this dynamical system in a Hilbert space. We prove that the trajectories of the proposed dynamical system converge strongly to a primal–dual solution of the considered problem. Under explicit time discretization of the dynamical system we obtain the best approximation algorithm for solving coupled monotone inclusion problem.
A comprehensive survey of industry practice in real-time systems
Authors: Akesson Benny , Nasri Mitra , Nelissen Geoffrey , Altmeyer Sebastian , Davis Robert I.
Published: November 2021

This paper presents results and observations from a survey of 120 industry practitioners in the field of real-time embedded systems. The survey provides insights into the characteristics of the systems being developed today and identifies important trends for the future. It extends the results from the survey data to the broader population that it is representative of, and discusses significant differences between application domains. The survey aims to inform both academics and practitioners, helping to avoid divergence between industry practice and academic research. The value of this research is highlighted by a study showing that the aggregate findings of the survey are not common knowledge in the real-time systems community.
A quantitative paleoclimatic reconstruction of the non-analogue environment of oxygen isotope stage 3: new data from small mammal records of southwestern Germany
Authors: Rhodes Sara E. , Conard Nicholas J.
Published: November 2021

Ensuring comparability between results is a key goal of all paleoecological reconstructions. Quantitative estimates of meteorological variables, as opposed to relative qualitative descriptions, provide the opportunity to compare local paleoenvironmental records against global estimates and incrementally build regional paleoclimatic records. The Bioclimatic Method provides quantitative and qualitative estimates of past landscape composition and climate along with measures of statistical accuracy by applying linear discriminant functions analysis and transfer functions to faunal taxonomic abundance data. By applying this method to the rodent data from Geißenklösterle and Hohle Fels, two Paleolithic cave sites located in the Ach Valley of southwestern Germany, we classify the regional vegetation according to Walters’ zonobiome model. We also present new estimates of meteorological variables including mean annual temperature, mean annual precipitation, and vegetative activity period of the Ach Valley for the period spanning ~ 60,000 to 35,000 cal BP. The results suggest the Ach Valley contained a non-analogous landscape of arctic tundra and temperate deciduous woodland with occasional arid steppe expansion. Meteorological estimates suggest the climate was significantly colder during the Middle and Upper Paleolithic than today, with higher annual precipitation and dramatic temperature shifts between seasons. These results fit well with climatic reconstructions from Switzerland and the Netherlands based on a variety of proxies. They also provide further evidence of a localized climatic response within southwestern Germany to the stadial-interstadial shifts preceding the Heinrich 4 event. Finally, these results reinforce our previous claims that climatic volatility was not a driving force in the loss of Neanderthal groups throughout the Swabian Jura during OIS 3.
Characteristics of water contamination in abandoned coal mines: a case study on Yudong River area, Kaili, Guizhou Province, China
Authors: Li Xiangdong , Cai Jieying , Chen Di , Feng Qiyan
Published: November 2021

The seasonal and spatial changes in the chemical composition of the water in abandoned mine drainages and rivers in Yudong River area in the years of 2017–2018 were analyzed. The effects of mine water drainage on the seasonality and physicochemical properties of the river water after mine closure were evaluated, and the feasibility of irrigation using river water and the degree of pollution to farmland were assessed using the Water Quality Standard for Farmland Irrigation. The results show that the mine water has low pH value (< 3.5–4) and high levels of total hardness, SO42−, Fe, Al, and Zn. In addition, the pH of the mine water is negatively correlated with the presence of other metal ions. The correlation coefficient between the chemical oxygen demand (COD) and Fe reached 0.989. While the pollution levels of Pinglu and Baishui rivers were low, the confluence region of the two rivers was seriously polluted. However, only the levels of Fe and Cd slightly exceeded the Surface Water Environmental Quality Standard after the confluence of Yudong and Chongan rivers. Overall, the heavy pollution type of the confluent river is consistent with mine water pollution. The water quality is slightly better in the dry season compared than in the high-water period. Sulfate and Fe content decreased by 39 and 16 mg/L, respectively, and Cd content decreased two-fold. Despite these findings, this study shows that from 2017 to 2018, the pH and Cd content of the rivers at the confluence exceeded the irrigation limit and the water quality continued to deteriorate, which may pose a soil contamination risk. Long-term use of the river for irrigation water may cause toxic elements such as Cd, Fe, Mn, SO42−, Al, and F- to enter the food chain, thereby endangering the life and health of villagers in Yudong River area.
Optimal design of optical analog solvers of linear systems
Authors: Imeri Kthim
Published: November 2021

In this paper, given a linear system of equations $$\mathbf {A}\, \mathbf {x}= \mathbf {b}$$

A

x
=
b

, we are finding locations in the plane to place objects such that sending waves from the source points and gathering them at the receiving points solves that linear system of equations. The ultimate goal is to have a fast physical method for solving linear systems. The issue discussed in this paper is to apply a fast and accurate algorithm to find the optimal locations of the scattering objects. We tackle this issue by using asymptotic expansions for the solution of the underlying partial differential equation. This also yields a potentially faster algorithm than the classical BEM for finding solutions to the Helmholtz equation.
Traveling waves for the nonlinear variational wave equation
Authors: Grunert Katrin , Reigstad Audun
Published: November 2021

We study traveling wave solutions of the nonlinear variational wave equation. In particular, we show how to obtain global, bounded, weak traveling wave solutions from local, classical ones. The resulting waves consist of monotone and constant segments, glued together at points where at least one one-sided derivative is unbounded. Applying the method of proof to the Camassa–Holm equation, we recover some well-known results on its traveling wave solutions.
On the rate of error growth in time for numerical solutions of nonlinear dispersive wave equations
Authors: Ranocha Hendrik , de Luna Manuel Quezada , Ketcheson David I.
Published: November 2021

We study the numerical error in solitary wave solutions of nonlinear dispersive wave equations. A number of existing results for discretizations of solitary wave solutions of particular equations indicate that the error grows quadratically in time for numerical methods that do not conserve energy, but grows only linearly for conservative methods. We provide numerical experiments suggesting that this result extends to a very broad class of equations and numerical methods.
Placenta Percreta Presents with Neoangiogenesis of Arteries with Von Willebrand Factor-Negative Endothelium
Authors: Schwickert Alexander , Henrich Wolfgang , Vogel Martin , Melchior Kerstin , Ehrlich Loreen , Ochs Matthias , Braun Thorsten
Published: November 2021

In placenta percreta cases, large vessels are present on the precrete surface area. As these vessels are not found in normal placentation, we examined their histological structure for features that might explain the pathogenesis of neoangiogenesis induced by placenta accreta spectrum disorders (PAS). In two patients with placenta percreta (FIGO grade 3a) of the anterior uterine wall, one strikingly large vessel of 2 cm length was excised. The samples were formalin fixed and paraffin-embedded. Gomori trichrome staining was used to evaluate the muscular layers and Weigert-Van Gieson staining for elastic fibers. Immunohistochemical staining of the vessel endothelium was performed for Von Willebrand factor (VWF), platelet endothelial cell adhesion molecule (CD31), Ephrin B2, and EPH receptor B4. The structure of the vessel walls appeared artery-like. The vessel of patient one further exhibited an unorderly muscular layer and a lack of elastic laminae, whereas these features appeared normal in the vessel of the other patient. The endothelium of both vessels stained VWF-negative and CD31-positive. In conclusion, this study showed VWF-negative vessel endothelia of epiplacental arteries in placenta accreta spectrum. VWF is known to regulate artery formation, as the absence of VWF has been shown to cause enhanced vascularization. Therefore, we suppose that PAS provokes increased vascularization through suppression of VWF. This process might be associated with the immature vessel architecture as found in one of the vessels and Ephrin B2 and EPH receptor B4 negativity of both artery-like vessels. The underlying pathomechanism needs to be evaluated in a greater set of patients.
Staging 'Euridice'
Authors: Carter Tim , Fantappiè Francesca
Published: November 2021

Euridice was one of several music-theatrical works commissioned to celebrate the wedding of Maria de' Medici and King Henri IV of France in Florence in October 1600. As the first 'opera' to survive complete, it has been viewed as a landmark work, but its libretto by Ottavio Rinuccini and music by Jacopo Peri and Giulio Caccini have tended to be studied in the abstract rather than as something to be performed in a specific time and place. Staging “Euridice” explores how newly-discovered documents can be used to precisely reconstruct every aspect of its original stage and sets in the room for which it was intended in the Palazzo Pitti. By also taking into account what the singers and instrumentalists did, what the audience saw and heard, and how things changed from creation through rehearsals to performance, this book brings new aspects of Euridice to light in startling ways.
From Traitor to Zealot
Authors: Koehler Daniel
Published: November 2021

What makes a neo-Nazi become a convinced anti-fascist or a radical left-winger become a devout Salafist? How do they manage to fit into their new environment and gain acceptance as a former enemy? The people featured in this book made highly puzzling journeys, first venturing into extremist milieus and then deciding to switch to the opposite side. By using their extraordinary life-stories and their own narratives, this book provides the first in-depth analysis of how and why people move between seemingly opposing extremist environments that can sometimes overlap and influence each other. It aims to understand how these extremists manage to convince their new group that they can be trusted, which also allows us to dive deep into the psychology of extremism and terrorism. This fascinating work will be of immense value to those studying radicalization and counter-radicalization in terrorism studies, social psychology and political science.
Surfactant spreading in a two-dimensional cavity and emergent contact-line singularities
Authors: Mcnair Richard , Jensen Oliver E. , Landel Julien R.
Published: November 2021

We model the advective Marangoni spreading of insoluble surfactant at the free surface of a viscous fluid that is confined within a two-dimensional rectangular cavity. Interfacial deflections are assumed small, with contact lines pinned to the walls of the cavity, and inertia is neglected. Linearising the surfactant transport equation about the equilibrium state allows a modal decomposition of the dynamics, with eigenvalues corresponding to decay rates of perturbations. Computation of the family of mutually orthogonal two-dimensional eigenfunctions reveals singular flow structures near each contact line, resulting in spatially oscillatory patterns of shear stress and a pressure field that diverges logarithmically. These singularities at a stationary contact line are associated with dynamic compression of the surfactant monolayer. We show how they can be regularised by weak surface diffusion. Their existence highlights the need for careful treatment in computations of unsteady advection-dominated surfactant transport in confined domains.
Shock-induced interfacial instabilities of granular media
Authors: Li Jiarui , Xue Kun , Zeng Junsheng , Tian Baolin , Guo Xiaohu
Published: November 2021

This paper investigates the shock-induced instability of the interfaces between gases and dense granular media with finite length via the coarse-grained compressible computational fluid dynamics–discrete parcel method. Despite generating a typical spike-bubble structure reminiscent of the Richtmyer–Meshkov instability (RMI), the shock-driven granular instability (SDGI) is governed by fundamentally different mechanisms. Unlike the RMI arising from baroclinic vorticity deposition on the interface, the SDGI is closely associated with the interfacial and bulk granular dynamics, which evolve with the transient coupling between particles and gases. Consequently, the SDGI follows a growth law distinctly different from that of the RMI, namely a semilinear slow regime followed by an exponentially expedited regime and a quadratic asymptotic regime. We further establish the instability criteria of the SDGI for granular media with infinite and finite lengths, which do not exist in the RMI. A scaling growth law of the SDGI for dense granular media with finite length is derived by normalizing the time with the rarefaction propagation time, which successfully collapses the data from cases with varying shock strength, particle column length and particle volume fraction and ought to hold for granular media with varying particle parameters. The effect of the initial perturbation magnitude can be properly considered in the scaling growth law by incorporating it into the length normalization.
Answering the Call of Conscience
Authors: Clayton Obie
Published: November 2021

This essay shows how three institutions—family, religion, and education—coalesced to shape the moral life of John Lewis. Lewis was born into a very religious, though uneducated, family who wished to see their son receive the education they were denied. The young Lewis took their zeal for education and religion into seminary and later college. It was in college that Lewis developed an intolerance for discrimination and came to champion the civil and human rights of all individuals. His call of conscience would not condone the suffering and abuse being generated by a segregated society. This passion for human rights led to his rising into prominence in the political arena, where many referred to him as the “conscience of the nation.”
A new perspective on women’s care burden and employment in Turkey
Authors: Ekiz Gökmen Çisel
Published: November 2021

Women’s intra-household care burden is one of the main reasons behind women’s low employment rates in Turkey. Many empirical studies have tested this relationship by focusing on the existence of dependent household members, if any. They have largely overlooked the use of care services and the time spent on caring for dependent household members to evaluate women’s care burden.

The purpose of this study is to examine the relationship between women’s care burden and employment prospects and status in Turkey from the perspective of access to care services and the time dimension of the care burden. This relationship is analyzed through the logit model by using latest available data from the 2014–2015 Time Use Survey. The article shows that the time spent by women caring for dependent household members, and access to care services, are the most important factors influencing women’s employment probability in Turkey. Benefiting from informal childcare services increases the employment probability of women approximately twenty-seven times, while benefiting from formal childcare services increases two times and informal adult-care services 2.6 times. Ensuring the accessibility of institutional care services improves women’s employment status by enabling women’s transition from part-time to full-time jobs, and from unskilled to professional jobs.
The interplay of childhood maltreatment and maternal depression in relation to the reward positivity in youth
Authors: Suor Jennifer H. , Granros Maria , Calentino Alison E. , Phan K. Luan , Burkhouse Katie L.
Published: November 2021

Guided by developmental psychopathology and dual-risk frameworks, the present study examined the interplay between childhood maltreatment and maternal major depression history in relation to neural reward responsiveness in youth. The sample consisted of 96 youth (ages 9–16; M = 12.29 years, SD = 2.20; 68.8% female) drawn from a large metropolitan city. Youth were recruited based on whether their mothers had a history of major depressive disorder (MDD) and were categorized into two groups: youth with mothers with a history of MDD (high risk; HR; n = 56) and youth with mothers with no history of psychiatric disorders (low risk; LR; n = 40). The reward positivity (RewP), an event-related potential component, was utilized to measure reward responsiveness and the Childhood Trauma Questionnaire measured childhood maltreatment. We found a significant two-way interaction between childhood maltreatment and risk group in relation to RewP. Simple slope analysis revealed that in the HR group, greater childhood maltreatment was significantly associated with reduced RewP. The relationship between childhood maltreatment and RewP was not significant among the LR youth. The present findings demonstrate that the association between childhood maltreatment and blunted reward responsiveness is dependent on whether offspring have mothers with histories of MDD.
Family Treatments for Individuals at Risk for Suicide
Authors: Sullivan Sarah R. , Spears Angela Page , Mitchell Emily L. , Walsh Samantha , Love Chase , Goodman Marianne
Published: November 2021

Abstract. Background: This PRISMA scoping review explored worldwide research on family-based treatments for suicide prevention. Research on this topic highlights the importance of facilitating familial understanding of a suicidal individual. Aim: The review sought evidence of outcomes of trials in which both the patient and family member in the intervention arm attended the same sessions at which suicide was openly discussed. Method: To explore this topic, the authors searched for randomized and nonrandomized controlled trials using Medline (Ovid), PsycINFO (Ovid), Social Services Abstracts (EBSCO), and Web of Science on July 8, 2020. Results: Ten different studies were included that spanned five treatment modalities. Specifically, of the interventions in these 10 articles, 40% employed some sort of cognitive-behavioral therapy, 20% examined attachment-based family therapy, 20% used family-based crisis intervention, and the remaining 20% were distinct interventions from one another. Additionally, several of these articles demonstrated rigorous study methodology and many of the articles reported significant improvements in suicidal ideation or behaviors. Conclusion: Several important research gaps were identified. While this approach has been largely understudied, and to date has been primarily researched in adolescent populations, family interventions have great potential for treatment and prevention of suicidality.
Extreme Water Vapor Transport During the March 2021 Sydney Floods in the Context of Climate Projections
Authors: Reid Kimberley J. , O'Brien Travis A. , King Andrew D. , Lane Todd P.
Published: November 2021

During March 2021, large regions of Eastern Australia experienced prolonged heavy rainfall and extensive flooding. The maximum daily mean column integrated water vapor transport (IVT) over Sydney during this event was within the top 0.3% of all days since 1980, and the 10‐day mean IVT was in the top 0.2%. In this study, we have examined the change in frequency of extreme IVT events over Sydney in 16 climate models from the Coupled Model Intercomparison Project 6 under two Shared Socioeconomic Pathways (SSP245 and SSP585). Generalized Extreme Value modeling was used to further analyze the change in frequency of extreme IVT events. We found the probability of long duration high IVT events is projected to increase by 80% at the end of the century, but the future change in IVT is correlated to the rate of global and regional warming in each model.
Probabilistic Linear Inversion of Satellite Gravity Gradient Data Applied to the Northeast Atlantic
Authors: Minakov Alexander , Gaina Carmen
Published: November 2021

We explore the mantle density structure of the northeast Atlantic region using constrained linear inversion of the satellite gravity gradient data based on statistical prior information and assuming a Gaussian model. The uncertainty of the residual gravity gradient signal is characterized by a covariance matrix obtained using geostatistical analysis of controlled‐source seismic data. The forward modeling of the gravity gradients in the 3D reference crustal model is performed using a global spherical harmonics analysis. We estimate the model covariance function in the radial and angular directions using a variogram method. We compute volumetric gravity gradient kernels for a spherical shell covering the northeast Atlantic region down to the mantle transition zone (410 km depth). The solution of the linear inverse problem in the form of the mean density model and the posterior covariance matrix follows a least squares approach. The results indicate that on average the seismic velocity variation is proportional to the density variation in the northeast Atlantic region. However, a noticeable mismatch or anti‐correlation exists in some areas, such as the Greenland‐Iceland‐Faroe ridge and southwestern Norway. The predicted low‐density anomalies at depths of 100–150 km underneath the northeast Atlantic Ocean are correlated with the distribution of Cenozoic submarine volcanoes and seamount‐like features of the seafloor.
Seismic Architecture of the Upper Mantle Underlying California and Nevada
Authors: Stanciu A. Christian , Humphreys Eugene D.
Published: November 2021

We present new P and S teleseismic tomography models of the upper mantle beneath California and Nevada. Improved tomographic methods and the incorporation of new data increase image resolution and seismic structure definition. Technical advancements include the use of 3‐D ray tracing, ray weighting and finite‐frequency sensitivity kernels. Together with the incorporation of modern crustal velocity models to account for crustal delay time, these tomographic advancements reveal slightly higher amplitudes and narrower structures beneath prominent tectonic features in California and Nevada. The addition of new data from the southern California Borderland and northwestern California are particularly useful. Based on our imaging results, we discuss the effects of temperature and partial melt on upper mantle seismic velocity beneath California and Nevada. We interpret the major seismically fast structures in our study area to be Juan de Fuca slab and its downward continuation beneath central Nevada and foundered Farallon lithosphere beneath the southern Sierra Nevada and Transverse Ranges. The seismically slow structures beneath the slab‐free window of northern California Coast Range, the Salton Trough extensional basin, and the Cascadia back arc, are all consistent with the presence of partial melting of decompressing mantle. The imaged seismically fast and slow anomalies imply buoyancy variations and melt productivity that ultimately act on the overlying crust.
YORP Effect on Asteroid 162173 Ryugu: Implications for the Dynamical History
Authors: Kanamaru Masanori , Sasaki Sho , Morota Tomokatsu , Cho Yuichiro , Tatsumi Eri , Hirabayashi Masatoshi , Hirata Naru , Senshu Hiroki , Shimaki Yuri , Sakatani Naoya , Tanaka Satoshi , Okada Tatsuaki , Usui Tomohiro , Sugita Seiji , Watanabe Sei‐ichiro
Published: November 2021

Asteroid 162173 Ryugu is a carbonaceous asteroid that was visited by Japan's Hayabusa2 spacecraft in 2018. The formation mechanism of the “spinning‐top” shape of Ryugu is a vital clue to the dynamical history of the near‐Earth asteroid. In this study, we address the long‐term evolution of its spin state induced by the Yarkovsky‐O’Keefe‐Radzievskii‐Paddack (YORP) effect, that is, the thermal recoil torque that changes the rotation period and spin‐pole direction. Given the current orbit, spin state, and three‐dimensional shape of Ryugu observed by Hayabusa2, we computed the YORP torque exerted on Ryugu using a simplified thermal model assuming zero thermal conductivity. Despite variations in the meter‐scaled topography, all 20 shape models that we examined indicate that the spin velocity of Ryugu is currently decreasing at a rate of deg/day2. Our findings also suggest that the thermal torque is responsible for maintaining the spin pole upright with respect to the orbital plane. Therefore, the YORP effect may explain the significant spin‐down from an earlier period of 3.5 hr to the present period of 7.6 hr. The corresponding time scale of the spin‐down is estimated to be 0.58–8.7 million years, depending on the input shape models. This time scale is comparable to the formation period of the largest crater, Urashima (5–12 Ma), or the western bulge (2–9 Ma) as derived from previous studies on crater statistics in Ryugu. Thus, its rotation may have started to decelerate as a consequence of major resurfacing events.
Wild-type isocitrate dehydrogenase under the spotlight in glioblastoma
Authors: Alzial Gabriel , Renoult Ophelie , Paris François , Gratas Catherine , Clavreul Anne , Pecqueur Claire
Published: November 2021

Brain tumors actively reprogram their cellular metabolism to survive and proliferate, thus offering potential therapeutic opportunities. Over the past decade, extensive research has been done on mutant IDH enzymes as markers of good prognosis in glioblastoma, a highly aggressive brain tumor in adults with dismal prognosis. Yet, 95% of glioblastoma are IDH wild-type. Here, we review current knowledge about IDH wild-type enzymes and their putative role in mechanisms driving tumor progression. After a brief overview on tumor metabolic adaptation, we present the diverse metabolic function of IDH enzymes and their roles in glioblastoma initiation, progression and response to treatments. Finally, we will discuss wild-type IDH targeting in primary glioblastoma.