bluuebunny/crossref_metadata_2025 huggingface dataset:
CONFLICT ON THE PROTECTION OF HUMAN RIGHTS RELATED TO TRADEMARK RIGHTS AND PUBLIC HEALTH RIGHTS: PROHIBITION OF DISPLAY OF CIGARETTE PACKAGES AT POINT-OF-SALE BASED ON INDONESIA'S POSITIVE LAW
Authors: Berliani Tamara Putri , Amirulloh Muhamad , Damian Eddy
Published: December 2023

In attempt to reduce tobacco consumption and implement preventive measures through regulations such as the prohibition of displaying cigarette packs at points of sale regulated by the WHO FCTC, a dilemma arises regarding the protection of the intellectual property rights of trade owners, with public health. Based on this background, this study aims to examine two objectives. First, regarding what legal theory may be used as a legal basis for Trademark Rights owners against the prohibition of displaying cigarette packs at points of sale and second, regarding whether the implementation of Law Number 20 of 2016 concerning Trademarks and Geographical Indications violates the WHO Framework Convention on Tobacco Control 2003 regarding the prohibition of displaying cigarette packs in points of sale. This study uses an adjusted approach method in this writing, namely through normative juridical and qualitative juridical approaches.
PENANGANAN BARANG BUKTI BENIH BENING LOBSTER MELALUI MEKANISME PELEPASLIARAN SEBAGAI UPAYA MELESTARIKAN KOMODITAS LOBSTER
Authors: Herdiana Widia , Sulistiani Lies , Imamulhadi Imamulhadi
Published: December 2023

ABSTRAK

Penyelundupan Benih Bening Lobster (BBL) merupakan permasalahan yang banyak disoroti sejak PERMEN KP Nomor 1 Tahun 2015 dibuat. Maraknya kasus menjadi masalah bagi ekosistem laut. Karenanya, berdasarkan PERMEN KP Nomor 17 Tahun 2021 mengatur mekanisme pelepasliaran barang bukti BBL. Pelepasliaran merupakan pelestarian spesies dengan cara mempertahankan keberadaan suatu spesies dengan menyerahkan perkembangan ke habitat aslinya. Proses pelepasliaran yang dilakukan penyidik perikanan merupakan salah satu cara untuk menegakkan hukum dalam melindungi ekosistem laut. Selain oleh penyidik, peran serta masyarakat untuk menjaga ekosistem laut juga penting. Metode penelitian: yuridis normatif yaitu menganalisis kenyataan dengan aturan hukum yang berlaku. Hasil disajikan dalam bentuk deskriptif untuk menggambarkan permasalahan yang ada yang kemudian dianalisis sehingga menghasilkan suatu kesimpulan. Kenyataan yang ada menunjukkan bahwa penegak hukum dalam proses penyidikan telah secara nyata menerapkan penanganan barang bukti BBL yang mengedepankan asas kelestarian. Tetapi aturan hukum terkait hal tersebut hanya ada pada tingkatan PERMEN bukan dalam tingkatan Undang-undang.

Kata kunci: Barang Bukt; BBL; Pelepasliaran.

ABSTRACT

Smuggling of Clear Lobster Seeds (BBL) is a problem that has been highlighted a lot since PERMEN KP Number 1 of 2015 was made. The rise of cases is a problem for the marine ecosystem. Therefore, based on PERMEN KP Number 17 of 2021 it regulates the mechanism for releasing BBL evidence. Release is the preservation of species by maintaining the existence of a species by surrendering its development to its natural habitat. The release process carried out by fisheries investigators is one way to enforce the law in protecting marine ecosystems. Apart from investigators, the role of the community in protecting marine ecosystems is also important. Research method: normative juridical, namely analyzing reality with the applicable legal rules. The results are presented in a descriptive form to describe the existing problems which are then analyzed to produce a conclusion. The existing facts show that law enforcers in the investigation process have actually implemented the handling of BBL evidence that prioritizes the principle of sustainability. However, legal regulations regarding this matter only exist at the PERMEN level, not at the Law level.

Keywords: BBL; Evidence; Release.
Sérgio Buarque de Holanda e Wilson Martins nos debates sobre a democracia no pós-Segunda-Guerra (1948-1951)
Authors: Pereira Marco Antônio Machado Lima
Published: December 2023

A proposta do artigo é analisar a participação de Sérgio Buarque de Holanda e Wilson Martins no comitê internacional convocado pela Organização das Nações Unidas para a Educação, a Ciência e a Cultura (UNESCO) para debater os diferentes significados atribuídos à noção de democracia. Parte relevante de nossa proposta consiste em abordar os embates entre os dois intelectuais brasileiros a partir dos artigos publicados por Sérgio Buarque de Holanda entre os anos 1949-1951, do livro de Wilson Martins, intitulado Introdução à democracia brasileira (1951), e das reflexões oriundas do simpósio Democracy In World Of Tensions, realizado em 1951.
Foucault, a reportagem de ideias e os direitos dos governados
Authors: Silva Leandro Mendanha e
Published: December 2023

Foucault pretendeu compreender a atualidade em que vivia de diversas formas: investigações histórico-filosóficas, experiência militante na GIP (Grupo de Informação sobre as Prisões) e em outros coletivos, diálogo com os diversos grupos franceses e internacionais com os quais trocava experiências e ideias. Uma dessas maneiras foi por meio da reportagem de ideias, que exerceu no Irã como jornalista das ideias e experiências que eram gestadas por lá à época da Revolução Iraniana. Nessa direção, podemos falar que essa experiência iraniana trabalhou, junto com outras que ele experimentava no mesmo período, seu próprio pensamento, modificando seu pensamento e problematizando aquela experiência.
Characteristics of Plural Phrase Formation in Al-Mu'jam Al-Şagīr Lijumū' Al-Taksīr Dictionary and Their Absorption in Learning Arabic at a Language Course
Authors: Putra Wahyu Hanafi , Baroroh R. Umi , Hadi Syamsul , Thamir As-Saady Thamir , Salma Kunti Nadiyah
Published: December 2023

This study aims to analyze the characteristics of the formation of plural phrases in the irregular plural noun dictionary Al-Mu'jam al-Şagīr lijumū' al-Taksīr by M. Muslikhin and identify their absorption patterns for learning Arabic at the Al-Azhar Language Course Institute, Pare Kediri. This qualitative research was done with two approaches: library research and case studies. Data sources were obtained from the dictionary and Arabic language course activities at the Al-Azhar Pare Kediri Language Course Institute. Data collection techniques were conducted by documentation and observation, and data analysis techniques were done by using data reduction, data presentation, and conclusion. The results showed that the compilation of the irregular plural noun dictionary of Al-Mu'jam al-Şagīr lijumū' al-Taksīr by M. Muslikhin has positive-pragmatic value in the development of Arabic lexicography and learning Arabic in Indonesia. Dictionaries that form particular phrases into plural phrases follow the pattern of wazan jam'u al-qillah wa jam'u al-kaṣrah. Some muṣṭalaḥāt in the dictionary is formed constructively (musytaq) and permanently (jāmid). Dictionaries are arranged in alphabetical order and are thematic. It is very appropriate to help with Arabic language course activities with various programs available at LKB Al-Azhar Pare Kediri and external institutions. The theoretical implication of this research is to develop Arabic lexicographic discourse in Indonesia. Meanwhile, the practical implication is to make it easier to search for Shighat Jama' Taksir on verbs in the dictionary.
Segmenting, Targeting, and Positioning Strategies in Attracting the Interest of Students in Learning Nahwu
Authors: Manshur Umar , Baharun Hasan , Dakir Dakir , Mahasini Zadana Bil
Published: December 2023

This research aims to analyze Segmenting, Targeting, and Positioning (STP) strategies to attract the interest of students studying Nahwu at the Nurul Jadid Islamic Boarding School, Probolinggo, East Java, Indonesia. This research uses a qualitative approach with a case study type of research. Researchers conducted observations, in-depth interviews, and documentation to obtain accurate, valid, and accountable data. Data analysis was carried out systemically, starting from data reduction, data presentation, and drawing research conclusions. This research shows that segmenting, targeting, and positioning, mapping, and placing students in learning Nahwu science is very important so that learning can provide comfortable and meaningful conditions for students; this can increase students' interest in studying Nahwu science. This research provides implications regarding the importance of appropriate segmentation, targeting, and positioning in learning Nahwu science so that educational institutions can increase students' interest in learning and involvement in studying Nahwu science more effectively, excitingly, and meaningfully so that learning objectives can be achieved maximally.
Investigating the Arabic /f/ Pronunciation: A Comparative Analysis of Acoustic Phonetics
Authors: Ali Mad , Sanusi Anwar , Maulani Hikmah , Saleh Nalahuddin , Khalid Shofa Musthofa , Supriadi Rinaldi , Al Farisi Mohamad Zaka
Published: December 2023

This study aims to understand the mispronunciation of the consonant /f/ in Arabic by Javanese Speakers (JS), Sundanese Speakers (SS) and Batak Speakers (BS). The focus is on the sound /f/ as it can shift to /p/ when spoken by speakers of various L1 languages. Javanese, Sundanese, and Batak were chosen because of their prominence in Indonesia. Using a descriptive-evaluative-comparative approach, the researchers analyzed the pronunciation of /f/ by JS, SS, BS, contrasted with a native speaker (NS), Sheikh Misyari bin Rasyid Al-'Afasi. The research data was in the form of sound recordings of the recitation of nine verses of the Quran with the sound /f/, collected using the listen-record-pay-attention technique and analyzed acoustically through Praat. The findings reveal phonetic interference in pronouncing/f/ at the beginning, middle, and end of words by SS and BS. In JS, it only occurs at the beginning and the end. The absence of sound /f/ in the phonological system of local languages can cause this interference. The implication lies in learning to listen and speak Arabic, helping to design strategies to overcome pronunciation errors when encountering foreign sounds in the learner's phonological system.
Development of Educative Magazine as a Bilingual Learning Medium Based on Arabic and English Vocabulary
Authors: Nisa' Luthfi Farihatun , Murtadho Nurul
Published: December 2023

The utilization of bilingual learning media based on educative magazines has been widely found in various educational practices today. However, its existence is still limited to being used in the field of science, even though the essence of the magazine as a mass communication medium is very close to its role in the language field. Therefore, this study aims to develop an educative magazine-based bilingual learning medium to improve Arabic and English vocabulary skills. This development research using Dick Carey's 1950 ADDIE model focuses on media development, so this research maximizes the process of analysis, design, development, and formative evaluation stages at each stage. Sources of research data are primary and secondary data obtained by interview techniques, literature studies, and expert test questionnaires. The data collected was then analyzed by using the interrater-agreement model technique to find a validity index. The research results based on language and material expert tests show an index of 1.0 with revisions. In contrast, the research results based on media expert tests show an index of 0.85 with revisions. Thus, it shows that this medium is very easy, precise, interesting, and suitable for future application in the bilingual learning process, which aims to understand and improve bilingual vocabulary.
Pengaruh Atraksi dan Aksesibilitas Terhadap Tingkat Kunjungan Wisatawan di Kebun Binatang Surabaya
Authors: Rahmatin Leily Suci , Jamil Nur Asyiah , Ardhana Awara Aleyda , Faudi Adinda Novaliza
Published: December 2023

Surabaya Zoo is a popular tourist attraction for different people both in Surabaya city and around East Java. Surabaya Zoo pursues the concept of recreational and educational tourism with a total of about 3,500 species of animals. The purpose of this study was to determine the impact of attractiveness and tourist accessibility on the number of tourist visits to Surabaya Zoo. The research method used is a quantitative approach with correlation research. Using a targeted sampling method, her 50 respondents of working age had visited Surabaya Zoo. The results show that different attractions and accessibility influence tourist visit levels by 59.7%. However, the attraction variable has a greater and significant influence on the level of tourist visits with a value of 0.626. Meanwhile, the accessibility variable has no significant effect on the level of tourist visits with a value of 0.190.
“Laughter and Sex Prolong Life”: Current Trends in the Humour Practices of Russian-Speakers in Estonia
Authors: Rubio Guillem Castañar , Fiadotava Anastasiya , Laineste Liisi
Published: December 2023

We investigate the humour production, consumption and sharing of Russian-speakers in Estonia, based on the self-reflections and self-perceptions of their humour preferences and other humour-related behaviour. By studying the representation of the humour practices of this important minority community we can get a more complete picture of humour in Estonia. Analysis of survey results reveals that according to Russian-speakers, among their favourite topics were everyday life, and sex- and family-related matters. Visual humour was the most popular form. Respondents mentioned social media as the primary way of sharing humour, but oral transmission remained important as well. The language of the shared humour was primarily Russian, and the content was mainly not specific to the Estonian cultural context. As humorous vernacular expression offers insights into the mechanisms of identity-building and integration, the choice of language and of source can be interpreted as a way to create and maintain a local identity. On the whole, Russian-speakers in Estonia are reluctant to discuss their minority status in a humorous manner.
Health-related Quality of Life in women with endometriosis; a systematic review
Authors: Kufyah Maria , Salem Talal
Published: December 2023

Endometriosis is a term that describes the ectopic implants of endometrial cells that grow progressively. Endometriosis is commonly associated with several symptoms, such as chronic pelvic pain, dyspareunia, dysmenorrhea, and dyschezia. Endometriosis negatively impacts several aspects of women\'s lives, such as physical, social, and psychological aspects, and as a result, it has a great impact on the health-related quality of life (HRQOL). This review aimed to assess the HRQOL among women suffering from endometriosis by reviewing the previous studies conducted on this subject. The databases of PubMed, Scopus, Elsevier, Science Direct, and Google Scholar were explored starting from 2019 till 2023. The included keywords were \"HRQOL, Impact, Influence, Effects, Correlation, Association, Women, Endometriosis, Assessment". The inclusion criteria were English original articles available for full-text and reported HRQOL among women with endometriosis. A total of 818 articles were obtained, and only eight studies were eligible for the inclusion criteria. The main findings included the impact of endometriosis on HRQOL and the affected domains. The factors that affected HRQOL, work productivity, and other assessed conditions. Endometriosis has negative impacts on HRQOL among women, and the HRQOL can be worse with the co-existence of additional factors. Also, endometriosis negatively affected the work productivity of affected women.
Gender Equality in Law Number 4 of 2019 Concerning Midwifery as a Fulfillment of Citizens' Constitutional Rights
Authors: Angraini Monica Viny , Hasyimzum Yusnani , Riananda Martha
Published: December 2023

Legal protection of human rights (HAM) is sought to avoid discriminatory acts, especially the midwifery sector as the fulfillment of basic rights inherent and protected by the constitution as stipulated in article 27 paragraph (2) of the 1945 Constitution of the Republic of Indonesia which states that every citizen has the right to work and a decent living for humanity. Thus violating the right to obtain work between men and women is a violation of human rights. However, Law Number 4 of 2019 Concerning Midwifery contains elements of discrimination in the midwifery profession, where men cannot become midwives, only limited to becoming obstetricians. Meanwhile, women have the freedom to choose to become midwives or obstetricians. The discrimination contained in the Midwifery Law needs to be analyzed from the perspective of the 1945 Constitution, as well as comparing regulations with the Netherlands to be able to describe the problem in depth. This research uses a normative-empirical legal method, which is a research method that will be studied combining 2 elements, namely normative legal elements and empirical legal elements. Normative law is based on literature data such as books in legal science literature, doctrines or expert opinions, scientific papers, articles, and journals, legislation and internet pages related to the problems in this study with author that can be accounted for. Empirical law is carried out based on field data as the main data source, which is generated through interviews with several informants related to the problems in this study. The results show that the formation of Law Number 4 of 2019 concerning Midwifery is considered contrary to some of the contents of the articles contained in the 1945 Constitution of the Republic of Indonesia, and the development of midwifery regulations in Indonesia needs to follow the example of the Netherlands by continuing to make men able to work as midwives, provided that the patient's consent is obtained.
Pendidikan Pradīkṣā dalam Lontar Putra Sasana
Authors: Sugiharta I Putu Suweka Oka , Herawan Kadek Dedy
Published: December 2023

Sulinggih has two main roles, namely as a ceremonial leader and community educator. There are also two things that must be possessed by a sulinggih in order to become the main teacher for the community: mature educational experience and a good reputation. Hinduism views education as a human need. Nevertheless, Sulinggih candidates are required to undergo a more rigorous educational process with denser material. If this is the case, then a sulinggih candidate will automatically have a good reputation and be declared fit to undergo the purification ritual as a sulinggih. The follow-up impact is that the quality of education born from this process makes all people maximally educated. The influence of modernism and image worship then led to a reduction in the educational process for sulinggih candidates. This led to the emergence of cases of sulinggih individuals who violated the norms of decency, religious norms, and legal norms. Meanwhile, in Lontar Putra Sesana, the educational method for sulinggih candidates has been patterned, which includes the dimensions of pedagogy, andragogy, and heutagogy. The purpose of this study is to provide reference material for the correct pattern of education for a candidate for sulinggih in Hinduism. This research method is qualitative, with an emphasis on library research. The findings of this study state that Lontar Putra Sesana contains the main teachings of Pradk education, which starts at an early age until one is ready to undergo purification as a sulinggih..
The U.K.’s ‘Appetite’ for Space: An Increased Craving!
Authors: Fox Sarah Jane
Published: December 2023

Launching into space was once the pursuit of super-power nations, who, during a period of international tensions, competed to be the first—the first into space and the first to the Moon. While the United Kingdom (U.K.) had a similar appetite it never achieved a space launch from its national soils, often thwarted by political and economic constraints. This said, the U.K. has played a key role, working alongside other nations in technological advancements related to space. This paper revisits the historical legacy of the U.K.’s space ventures and its space policies before comment is made to the current strategy and future vision. The approach is interdisciplinary and factors in semi-quasi case studies, particularly factoring in the European Space Agency. The findings are that the U.K. is returning to its original goal, with a renewed appetite to be a global leader in space launches, while also aiming to protect national interests which have necessitated closer alignment of the civil and defense space strategies.
Kajian Numerik Kesalahan Hasil Pengukuran Geolistrik 2D Terhadap Target Model 3D: Studi Kasus Pengukuran di Dekat Gedung Berpondasi Beton
Authors: Hartantyo Eddy
Published: December 2023

Survei geolistrik 2D dikaji berdasarkan asumsi bahwa model geolistrik bawah permukaan yang dihadapi adalah model 2D, dimana tidak terdapat variasi nilai resistivitas pada horisontal arah tegak lurus lintasan. Namun, pada beberapa kondisi, asumsi ini memberikan kesalahan ketika model yang dihadapi ternyata adalah model 3D. Pada paper ini dituliskan kajian komputasi terhadap pengaruh keberadaan pondasi bangunan terhadap lintasan-lintasan geolistrik di sampingnya. Model berukuran  node dengan spasi horisontal 0,5 m, tersusun oleh 4 lapisan akuifer normal yang mendatar. Digunakan 21 node tambahan untuk syarat batas Neuwmann di sisi-sisi model selain permukaan. Pada 5 node di sisi utara diberikan model blok pondasi sebuah bangunan. Perhitungan dilakukan menggunakan penyelesaian beda hingga Res3Dmod pada 21 lintasan untuk 4 konfigurasi: Schlumberger, Wenner, Dipole-dipole dan Pole-pole. Hasil kajian menunjukkan bahwa; pada kajian nilai selisih resistivitas semu pada area pondasi, konfigurasi Dipole-dipole memberikan respon yang paling tinggi terhadap kesalahan tersebut hingga pada jarak 11 m untuk selisih resistivitas semu  <3 , sedangkan ketiga konfigurasi yang lain berada pada jarak 8 m. Nilai eror secara keseluruhan kurang dari 1%: Wenner dan Pole-pole sejauh 10 m dari pondasi, Schlumberger sejauh 11 m dari pondasi, dan Dipole-dipole sejauh 13 m dari pondasi. Konfigurasi Wenner memberikan respon yang paling baik dan konfigurasi Wenner juga merupakan konfigurasi yang direkomendasikan untuk menghindari kesalahan pengukuran 2D akibat keberadaan model 3D di bawahnya.
Quantitative Caffeine Analysis in Robusta Coffee Utilizing Amperometric Biosensing Technology
Authors: Rosandi Vira Annisa , Umar Lazuardi , Setiadi Rahmondia Nanda , Rini Ari Sulistyo , Erwin Erwin , Yanuar Yanuar , Linda Tetty Marta
Published: December 2023

Consuming caffeine in inappropriate amounts can disrupt various aspects, especially health. Controlling intake by knowing the caffeine levels in coffee is necessary to reduce the potential negative impacts. This research focuses on the detection of caffeine in Robusta coffee at two different concentrations (1:10 and 1:20 g/mL) and its relationship with yeast metabolism. An amperometric biosensor with a transimpedance amplifier to measure caffeine levels is used which has the advantages of sensitivity, cost-effectiveness, real time monitoring, biocompatibility, and reliable measurements. The data were statistically analyzed using ANOVA and visualized using Principal Component Analysis (PCA). The results revealed a concentration -dependent decrease in biosensor readings as caffeine levels increased (0.1, 0.5, 1, 1.5, and 2 mM), indicating caffeine's ability to inhibit yeast oxygen consumption and oxygen-dependent metabolic processes. The sensitivity of the biosensor in detecting caffeine is 36.66 mV/mM. PCA uncovered complex patterns, relationships, and variations within the caffeine data. PC1 and PC2, the first two principal components, collectively explained 86.3% of the data's variance. Eigenvalues for both PCs were greater than 1, highlighting their significance in understanding the dataset's complexity. This research enhances our understanding of caffeine content in Robusta coffee and its effects on yeast metabolism, providing valuable insights for the coffee industry. This use of yeast biosensors offers efficiency, and adaptability that make that biosensor valuable in a variety of scientific and industrial contexts.
Unveiling a Rare Complication: Gemcitabine-Induced Cardiomyopathy in Ovarian Serous Adenocarcinoma
Authors:   Department of Clinical Oncology Pharmacy, Cancer Care Hospital & Research Centre, Lahore, Punjab, Pakistan, Nabeel Muhammad , Ali Khubaib ,   Akhtar Saeed College of Pharmaceutical Sciences, Bahria Town, Lahore, Punjab, Pakistan
Published: December 2023

Gemcitabine is a nucleoside analogue and pyrimidine antimetabolite authorized for the treatment of ovarian cancer. It is generally considered safe and well-tolerated, with only a few reported cases of cardiac adverse effects. However, we present a case of gemcitabine-induced dilated cardiomyopathy in a 33-year-old female receiving gemcitabine as second-line therapy for ovarian serous adenocarcinoma. The patient had no history of hypertension or significant cardiac issues. She presented with clinical symptoms, laboratory abnormalities, and imaging findings consistent with congestive cardiac failure, along with a Left Ventricular Ejection Fraction (LVEF) of 25-30%. Gemcitabine administration was immediately discontinued, and treatment with Furosemide, ACE inhibitors, and Beta-blocker agents was initiated. Subsequently, the patient’s condition improved, with the resolution of symptoms and normalization of cardiac findings upon discontinuation of gemcitabine. This is the first reported case demonstrating objective evidence of gemcitabine-induced dilated cardiomyopathy in a patient with ovarian serous adenocarcinoma without a significant cardiac history. Although rare, it is crucial to promptly diagnose gemcitabine-induced cardiomyopathy to initiate appropriate management protocols.
An Iatrogenic Hepato-Peritoneal Hydatidosis Revealed at the Stage of Abdominal Cutaneous Fistula: A Case Report
Authors:   Visceral Surgery Service II, Military Teaching Hospital Mohamed V, Ibn Sina University Hospital Centre, Rabat, Morocco, Bourouail Othmane , Rahali Anwar ,   Visceral Surgery Service II, Military Teaching Hospital Mohamed V, Ibn Sina University Hospital Centre, Rabat, Morocco, Halim Elmustapha ,   Visceral Surgery Service II, Military Teaching Hospital Mohamed V, Ibn Sina University Hospital Centre, Rabat, Morocco, Laalou Abdelkarim ,   Visceral Surgery Service II, Military Teaching Hospital Mohamed V, Ibn Sina University Hospital Centre, Rabat, Morocco, Elfadili Aziz ,   Visceral Surgery Service II, Military Teaching Hospital Mohamed V, Ibn Sina University Hospital Centre, Rabat, Morocco, Noureddine Njoumi ,   Visceral Surgery Service II, Military Teaching Hospital Mohamed V, Ibn Sina University Hospital Centre, Rabat, Morocco, Elhjouji Abderrahman ,   Visceral Surgery Service II, Military Teaching Hospital Mohamed V, Ibn Sina University Hospital Centre, Rabat, Morocco, Zentar Aziz ,   Visceral Surgery Service II, Military Teaching Hospital Mohamed V, Ibn Sina University Hospital Centre, Rabat, Morocco, Aitali Abdelmounaim ,   Visceral Surgery Service II, Military Teaching Hospital Mohamed V, Ibn Sina University Hospital Centre, Rabat, Morocco
Published: December 2023

Hydatidosis is a parasitic disease caused by the development of the larval form of Echinococcus granulosus, it is a significant public health problem in Morocco due to its frequency and the severity of some of its complications. Hepato-peritoneal hydatidosis is a rare serious condition, with a high risk of recurrence and significant morbidity and mortality. The peritoneal localization is most frequently iatrogenic caused by a previous hydatidosis surgery; the revelation by external abdomino-parietal fistulization makes it more uncommon. The large laparotomy surgery excision is the chosen treatment. Furthermore, to prevent possible recurrence a long-term antiparasitic therapy should be implemented. In our case, it was an intra-abdominal hydatid contamination due to the iatrogenic intraperitoneal rupture of the hepatic hydatidosis. This condition was revealed at the stage of cutaneious abdominal fistulization. The abdominal CT scan showed both positive and topographic diagnosis. our therapeutic strategy associated a large laparotomy surgery and antiparasitic medical treatment. The secondary peritoneal hydatidosis caused by iatrogenic trauma is rare but constitute a serious problem with short free recurrence disease and a high risk of morbi-mortality. This case illustrates the potential complication of hydatid cyst surgery, and the latency of the peritoneal localization.
Integrating Artificial Intelligence for Improved Management of Frozen Shoulder and Complications in Breast Cancer Surgery: A Perspective from Thailand
Authors:   Faculty of Integrative Medicine, Rajamangala University of Technology Thanyaburi, Pathum Thani, 12130, Thailand, Pasachan Tipthida , Tanajak Pongpan ,   Department of Physical Therapy, Rehabilitation Center, Apinop Wetchakam Hospital, Kaeng-Khoi District, Saraburi 18110, Thailand
Published: December 2023

Breast cancer is a leading cause of mortality among women worldwide, necessitating surgical interventions like lumpectomy, mastectomy, or modified radical mastectomy. However, these procedures often lead to postoperative complications, such as frozen shoulder, significantly impacting patients’s quality of life. This review focuses on the challenges associated with frozen shoulder and other complications following breast cancer surgery. It proposes the integration of Artificial Intelligence (AI) in assessment and intervention as a cost- effective solution. Frozen shoulder, also known as adhesive capsulitis, affects around 22.2% of breast cancer patients, particularly those undergoing axillary approaches. It is frequently accompanied by Axillary Web Syndrome (AWS) and Post-Mastectomy Pain Syndrome (PMPS), resulting in pain, limited range of motion, and compromised functional abilities. Conservative treatments, including exercises and rehabilitation programs, have shown positive outcomes in managing these symptoms. Previous studies have demonstrated the effectiveness of exercises, joint mobilization techniques, and home-based exercise programs in improving muscle strength, range of motion, and functional ability in breast cancer survivors. Abnormal neuromuscular control and kinematic distortions in shoulder and spinal movements have also been identified, highlighting the significance of neuromuscular training for shoulder joint complex recovery. The integration of AI in the assessment and intervention of frozen shoulder can offer cost-effective solutions and reduce waiting times at healthcare centers in Thailand. AI technologies can enable precise evaluations and personalized treatment plans, optimizing patient outcomes and resource utilization. In conclusion, physical therapy plays a crucial role in managing frozen shoulder and other complications following breast cancer surgery. Evidence-based practices, including comprehensive patient education, tailored exercise programs, manual therapy techniques, and pain management strategies, are essential for effective treatment. Integrating AI in assessment and intervention can further enhance outcomes and alleviate the burden on healthcare resources.
Relationship between Lower-Limb Bioelectrical Impedance Indicators of Hydration Status and Muscle Function in Aged Population: A Cross-Sectional Study
Authors:   Research Unit, Consorci Sanitari del Maresme, Spain, Prat Mateu Serra , Lorenzo Isabel ,   Information Management Unit, Consorci Sanitari del Maresme, Spain, Cabré Mateu ,   Department of Internal Medicinem Consorci Sanitari del Maresme, Spain, Martínez Jessica ,   Dietetics and Nutritional Unit, Consorci Sanitari del Maresme, Spain, Palomera Elisabet ,   Research Unit, Consorci Sanitari del Maresme, Spain, Ferrer Pau ,   Tecnocampus Fundation, Spain, Burdoy Emili ,   Department of Primary Care, Consorci Sanitari del Maresme, Spain), Pleguezuelos Eulogio ,   Department of Rehabilitation, Hospital of Mataró, Consorci Sanitari del Maresme, Spain
Published: December 2023

Background: Reduced Intracellular Water (ICW) has been related to poor muscle strength and functional capacity in aged populations. We aimed to evaluate hydration status and intracellular hydration of lower-limb lean mass in aged population and the relationship with thigh muscle function. Methods: Design and population: Cross-sectional study of community-dwelling ≥70 year old subjects. Measurements: Lower-limb hydration status was assessed by bioimpedance analysis and thigh muscle function was assessed by isokinetic evaluation. Frailty was established according to Fried criteria, sarcopenia according to EWGSOP-2 criteria, and physical performance according to the Timed Up-and-Go (TUG) test. Results: Assessed were 117 individuals (mean age 75.0 years, 50.4% women). Women had lower Fat-Free Mass (FFM), Total Body Water (TBW), and Phase Angle (PhA) values than men. Age was negatively correlated with ICW (r=-0.187; p=0.045), the ICW/FFM ratio (r=-0.192; p=0.039), and PhA (r=-0.311; p<0.001). Extension and flexion strength and power of the knee were positively correlated with Total Water (TW) (L), FFM (kg), and the protein compartment (kg) of the lower-limb in both men and women, but not with TW as percentage of weight, ICW as percentage of TW, and the TW/FFM and ICW/FFM ratios, while the TUG test was negatively correlated with ICW as a percentage of TW. Conclusion: Knee flexion and extension strength, power, and work increase as thigh FFM, TBW, and protein compartment values increase. No correlation was observed between intracellular hydration and muscle function, but correlation was observed with performance. As plausible hypotheses, further studies are required to test for these correlations.
Quality of the Support Network and Family Functionality in patients with Parkinson’s Disease
Authors:   Department of Family Medicine, General Hospital Zone with Family Medicine, Mexico, CM Guerra-Bulnes , HE Mercado-Flores ,   Department of Family Medicine, General Hospital Zone with Family Medicine, Mexico, JA Lopez-Moran ,   Department of Family Medicine, General Hospital Zone with Family Medicine, Mexico
Published: December 2023

Background: An inadequate support network and dysfunctional family functionality can be associated with a greater complication of your disease, as well as higher costs of care. These two elements play a decisive role in the clinical evolution of the patient with Parkinson’s disease. Objective: To evaluate the quality of the Support Network and Family Functionality in patients with Parkinson’s Disease. Methods: Non-experimental, cross-sectional, analytical and prospective study. The inclusion criteria were valid beneficiaries, with diagnosis of Parkinson’s Disease, it was carried out during the period from January to June 2022. To evaluate the Support Network the Gijon Scale was used and for Family Functionality the FF-SIL Test. For the statistical analysis we used descriptive statistics with measures of central tendency and dispersion, in the inferential analysis Fisher’s Exact Test and odds ratio were used. Results: Twenty-seven people diagnosed with Parkinson’s disease were evaluated. 21 participants (77.8%) had a moderately functional family, four with a dysfunctional family (14.8%) and two (7.4%) with a functional family. On the other hand, in the Gijon Scale we find the following: 15 patients (55.6%) with good/acceptable social situation and 12(44.4%) with social risk. When making an association between these variables, we found statistical significance with the absence of a partner (p 0.04), income of 1-2 minimum wages (p 0.001) and low socioeconomic level (p 0.02). Conclusions: Although there is no statistical association between the support networks with respect to family function, both aspects influence the environment and care of the patient with Parkinson’s. In turn, it is necessary to evaluate other interesting variables such as the presence of a partner, income and socioeconomic level.
Postponed Immediate Hypersensitivity Reaction to Ceftriaxone
Authors:   Bait Balev Nesher and The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel, S Kassem , E Jabareen ,   Bait Balev Nesher and The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel, JE Naschitz ,   Bait Balev Nesher and The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
Published: December 2023

Ceftriaxone is a widely used and generally safe 3rd generation cephalosporine. Immediate, IgE-mediated hypersensitivity reactions to ceftriaxone have been reported. We present a case of an elderly woman who received ceftriaxone 3 times over a period of 1 year. During the 1st course 1 year before the current event, the patient developed an atypical eruption on the seventh dose. Three months afterwards (9 months prior to the current event), unaware of the previous reaction, ceftriaxone was administered again. The first dose went uneventfully. Subsequently, being informed on the recent eruption, no second dose was administered. Noticing no hypersensitivity reaction to the unintentional re-challenge, skepticisms rose regarding the allergic nature of the former event. Nine months later (the current event), ceftriaxone was started for the third time. The 1st dose passed event-free, but after the second dose the patient mounted an immediate hypersensitivity reaction in the form of wide-spread urticaria. Postponed hypersensitivity reaction in this patient was explained by a three-step immune response: primary sensitization in earlier exposures, boosting the immune memory by 1st dose, to fast secretion of specific antibody, and the second dose to eliciting the immediate hypersensitivity reaction. We learned that on re-exposure of the sensitized patient the immediate hypersensitivity reaction may be postponed and that tolerance to the first dose of the antibiotic is no guarantee to being tolerant to the second dose.
Pedunculated Natal Tooth
Authors:   Department of Family Medicine, University of North Carolina at Chapel Hill, USA., J Ruiz
Published: December 2023

A newborn male was found to have a 2mm x 3mm hard yellow mass attached to a fleshy pedunculated stalk connected to the inferior mandibular gingiva (Figure 1). No other abnormalities were noted. The patient was born to a 21-year-old Black female G1P0 at 39 weeks and 2 days via vaginal delivery. Prenatal care was uncomplicated.
Transverse Myelitis Caused by Spinal Dural Arteriovenous Fistula: A Case Report
Authors:   Department of Family Medicine, Washington Health System, USA, AM Fix , R Happel ,   Department of Family Medicine, Washington Health System, USA, B Peterson ,   Department of Family Medicine, Washington Health System, USA
Published: December 2023

Spinal cord pathology is a diverse topic with a broad range of causes. Etiologies include trauma, inflammatory processes, infections, vascular disease, neoplasm, degenerative conditions and toxin exposure. Regardless of etiology, spinal pathology often presents as rapidly progressive paraparesis. Transverse Myelitis (TM) is a rare, acute segmental inflammatory spinal cord disorder characterized with motor, sensory, and/or autonomic dysfunction. This process usually occurs post-infection, but may also be related to acute neuro-inflammatory disorders. This paper will present a case of TM refractory to medication and describe the diagnosis of Spinal Dural Arteriovenous Fistula (SDAVF). SDAVF is a rare condition in which there is an arteriovenous fistula formed on the dural surface of the spinal cord which typically drains via retrograde flow through the medullary vein, thereby causing enlargement of coronal venous plexus.
Anemia and Microvascular Complications in Type 2 Diabetes Mellitus
Authors:   Department of Family Medicine, Family Medicine Unit #17, IMSS, Colima, Mexico, PA Esquivel-Brambila , UR Ramírez-Málaga ,   Department of Family Medicine, Family Medicine Unit #17, IMSS, Colima, Mexico, ML Basurto-Acevedo ,   Endocrine Research Unit, Centro Medico Nacional Siglo XXI, IMSS, Mexico City, Mexico, MS Ortiz-Mesina ,   Medical Auxiliary Coordination of Health Research, Headquarters of Medical Services, IMSS, Colima, Mexico
Published: December 2023

Background: In Type 2 Diabetes Mellitus, anemia affects tissue oxygenation and glycemic homeostasis, which promotes the premature onset of microvascular damage. Objective: To determine the association between the degree of anemia and microvascular complications in patients with type 2 diabetes mellitus. Methods: This is a cross-sectional, analytical study. Patients with diabetes mellitus and any complications were included. A review of electronic medical records of patients who met the selection criteria was conducted. The information was captured in a database previously structured in the SPSS statistical software and analyzed using inferential statistics. Results: With a total of 113 patients, with an average age of 62.23±10.3 years. Of the patients with Type 2 Diabetes Mellitus, 54.9% (62) presented with anemia. Of these, 46.9% (53) presented with Grade I, 5.3% (6) with Grade II, and 2.7% (3) with Grade III anemia, according to the World Health Organization. In terms of microvascular complications, only 5.3% (6) of those with diabetic retinopathy presented with anemia, the most frequent being Grade I. In the group of patients with diabetic neuropathy, Grade I was found in 19.5% (22), and with nephropathy it was 35.4% (40), with 30.1% (34) being Grade I.
On the equivalence of grand-canonical and capacitor-based models in first-principle electrochemistry
Authors: Kastlunger Georg , Vijay Sudarshan , Sharma Shubham , Chen Xi , Peterson Andrew
Published: December 2023

First principles-based computational and theoretical methods are constantly evolving trying to overcome the many obstacles towards a comprehensive understanding of electrochemical processes on an atomistic level. One of the major challenges has been the determination of reaction energetics under a constant applied potential. Here, a theoretical framework was proposed applying standard electronic structure methods and extrapolating to the infinite-cell size limit where reactions do not alter the potential. More recently, grand-canonical modifications to electronic structure methods which hold the potential constant by varying the number of electrons in a finite simulation cell have gotten increasingly popular. In this perspective, we show that these two schemes are thermodynamically equivalent. Further, we link these methods to ones based on capacitive models of the interface, in the limit that the capacitance of the charging components (whether continuum or atomistic) are equal and invariant along the reaction pathway. We further benchmark the three approaches with an example of alkali cation adsorption on Pt(111) proving that all three approaches converge in the cases of Li, Na and K. For Cs, however, strong deviation from the ideal conditions leads to a spread in the respective results. We discuss the latter by highlighting the cases of broken equivalence and assumptions among the approaches.
Porphyrins in Photodynamic Therapy: A Review
Authors: Sharma Debdulal , Sengupta Devashish
Published: December 2023

Porphyrins have emerged as versatile and highly effective photosensitizers in the field of photodynamic therapy (PDT). This promising therapeutic approach relies on the light-induced generation of reactive oxygen species (ROS) by photosensitizing agents. This comprehensive review explores the multifaceted role of porphyrins across various PDT applications, encompassing anticancer PDT, immuno-PDT, antimicrobial PDT, and antiviral PDT. Porphyrins exhibit the potential to serve as organic supramolecular platforms for developing various photosensitizers (PSs) tailored for specific PDT modalities. The exceptional capacity of porphyrins to specifically accumulate in target cancer cells or microorganisms, their proficiency in generating ROS upon exposure to light, and their capability to amass within cell mitochondria to facilitate apoptosis establish porphyrins as invaluable assets in a wide array of therapeutic applications. Ongoing research endeavours and clinical investigations continually unveil the vast potential of porphyrin-based PDT in combatting a wide range of diseases, spanning from cancer and infections to viral ailments. Furthermore, porphyrins hold promise in addressing drug-resistant cancers and antimicrobial resistance through non-invasive PDT, offering efficient alternatives to commercially available PDT drugs. In the context of advanced cancer management, porphyrin-based PDT offers the prospect of combinatorial therapy, enabling a sequence of immunogenic post-PDT actions that can effectively overcome anticancer resistance and tackle metastatic cancers. The future of PDT appears promising, with porphyrin scaffolds expected to play pivotal roles in advancing this field.
Intensified continuous flow process for the scalable production of bio-based glycerol carbonate
Authors: Muzyka Claire , Renson Sébastien , Grignard Bruno , Detrembleur Christophe , Monbaliu Jean-Christophe
Published: December 2023

A subtle combination of fundamental and applied organic chemistry toward process intensification is demonstrated for the large-scale production of bio-based glycerol carbonate under flow conditions. The direct carbonation of bio-based glycidol with CO2 is optimized under intensified flow conditions, with Barton’s base as a potent homogeneous organocatalyst. Process metrics for the CO2 coupling step (output: 3.6 kg day-1, Space Time Yield (STY): 2.7 kg h-1 L-1, Environmental factor (E-factor): 4.7) outclass previous reports. High conversion and selectivity are achieved in less than 30 s of residence time at pilot scale with a stoichiometric amount of CO2. Supporting DFT computations reveal the unique features of the mechanism in presence of Brønsted bases.
Human RAD52 stimulates the RAD51-mediated homology search
Authors: Muhammad Ali Akbar , Basto Clara , Peterlini Thibaut , Guirouilh-Barbat Josée , Thomas Melissa , Veaute Xavier , Busso Didier , Lopez Bernard , Mazon Gerard , Le Cam Eric , Masson Jean-Yves , Dupaigne Pauline
Published: December 2023

Homologous recombination (HR) is a DNA repair mechanism of double-strand breaks and blocked replication forks, involving a process of homology search leading to the formation of synaptic intermediates that are regulated to ensure genome integrity. RAD51 recombinase plays a central role in this mechanism, supported by its RAD52 and BRCA2 partners. If the mediator function of BRCA2 to load RAD51 on RPA-ssDNA is well established, the role of RAD52 in HR is still far from understood. We used transmission electron microscopy combined with biochemistry to characterize the sequential participation of RPA, RAD52, and BRCA2 in the assembly of the RAD51 filament and its activity. Although our results confirm that RAD52 lacks a mediator activity, RAD52 can tightly bind to RPA-coated ssDNA, inhibit the mediator activity of BRCA2, and form shorter RAD51-RAD52 mixed filaments that are more efficient in the formation of synaptic complexes and D-loops, resulting in more frequent multi-invasions as well. We confirm the in situ interaction between RAD51 and RAD52 after double-strand break induction in vivo. This study provides new molecular insights into the formation and regulation of presynaptic and synaptic intermediates by BRCA2 and RAD52 during human HR.
A Support Vector Machine Based Synthesis of Suboptimal Feedbacks for Linear Optimal Control Problems
Authors:   Belarusian State University, Dmitruk N. M. , Hatavets M. A. ,   Belarusian State University
Published: December 2023

Optimal feedback synthesis for two linear optimal control problems is studied: The terminal problem and the problem of minimizing the total impulse of the control. The main contribution of the paper is a method for constructing suboptimal feedbacks in the problems under consideration, based on a linear binary data classification for datasets obtained during the simulation process or real-time control of the system.