bluuebunny/crossref_metadata_2025 huggingface dataset:
Definition and Time Evolution of Correlations in Classical Statistical Mechanics
Authors: Dufour Claude G.
Published: November 2018

The study of dense gases and liquids requires consideration of the interactions between the particles and the correlations created by these interactions. In this article, the N-variable distribution function which maximizes the Uncertainty (Shannon’s information entropy) and admits as marginals a set of (N−1)-variable distribution functions, is, by definition, free of N-order correlations. This way to define correlations is valid for stochastic systems described by discrete variables or continuous variables, for equilibrium or non-equilibrium states and correlations of the different orders can be defined and measured. This allows building the grand-canonical expressions of the uncertainty valid for either a dilute gas system or a dense gas system. At equilibrium, for both kinds of systems, the uncertainty becomes identical to the expression of the thermodynamic entropy. Two interesting by-products are also provided by the method: (i) The Kirkwood superposition approximation (ii) A series of generalized superposition approximations. A theorem on the temporal evolution of the relevant uncertainty for molecular systems governed by two-body forces is proved and a conjecture closely related to this theorem sheds new light on the origin of the irreversibility of molecular systems. In this respect, the irreplaceable role played by the three-body interactions is highlighted.
Macroeconomic and Distributional Impacts of Jatropha Based Biodiesel in Mali
Authors: Boccanfuso Dorothée , Coulibaly Massa , Savard Luc , Timilsina Govinda
Published: November 2018

Mali has introduced a program to produce biodiesel using jatropha, a shrub widely available throughout the country. The aim of the program is to partially substitute diesel, which is entirely supplied through imports, with domestically produced biodiesel. In this paper, we use a computable general equilibrium (CGE) model and a microsimulation model to analyze macroeconomic and distributional impact of a hypothetical expansion of jatropha based biodiesel industry in Mali. We find that the expansion of biodiesel industry (i.e., both jatropha farming and oil conversion), would increase GDP, though slightly, if idle lands are utilized for jatropha cultivation. However, the expansion of jatropha would cause slight loss in GDP if the existing agriculture land is used for jatropha cultivation. The distributional results are slightly different. We find that rural poverty would decrease no matter whether idle lands or existing agricultural lands are used for jatropha plantation, although the percentage reductions in rural poverty are higher in the former compared to the latter case. Our results indicate that if governments plan to promote jatropha biodiesel they should not allow jatropha to compete with food staples on the existing land. Policies should be targeted to utilize the idle lands which have not been used for any productive use.
An Analytical Subdomain Model of Torque Dense Halbach Array Motors
Authors: Mallek Moadh , Tang Yingjie , Lee Jaecheol , Wassar Taoufik , Franchek Matthew A. , Pickett Jay
Published: November 2018

A two-dimensional mathematical model estimating the torque of a Halbach Array surface permanent magnet (SPM) motor with a non-overlapping winding layout is developed. The magnetic field domain for the two-dimensional (2-D) motor model is divided into five regions: slots, slot openings, air gap, rotor magnets and rotor back iron. Applying the separation of variable method, an expression of magnetic vector potential distribution can be represented as Fourier series. By considering the interface and boundary conditions connecting the proposed regions, the Fourier series constants are determined. The proposed model offers a computationally efficient approach to analyze SPM motor designs including those having a Halbach Array. Since the tooth-tip and slots parameters are included in the model, the electromagnetic performance of an SPM motor, described using the cogging torque, back-EMF and electromagnetic torque, can be calculated as function of the slots and tooth-tips effects. The proposed analytical predictions are compared with results obtained from finite-element analysis. Finally, a performance comparison between a conventional and Halbach Array SPM motor is performed.
The Spatiotemporal Distribution Law of Microseismic Events and Rockburst Characteristics of the Deeply Buried Tunnel Group
Authors: Zhang Heng , Chen Liang , Chen Shougen , Sun Jianchun , Yang Jiasong
Published: November 2018

Rockburst disaster is one of the prominent problems faced by deep underground engineering. Microseismic (MS) monitoring techniques can be used to warn of rockburst in tunnels to provide scientific basis for rock burst prevention and control measures. Described in this paper, is an MS monitoring system based on MS source location with hierarchical strategy implemented in the tunnel group of the Jinping II hydropower station in Sichuan Province, China. The spatiotemporal distribution of MS events was analyzed in the construction process and the size effect of rockburst risk discussed by statistical analysis and numerical calculation of rockburst in seven tunnels. The results show that the active period of microseisms and the high-incidence period of rockburst are within 1.5 h after the rock disturbance. The MS events within 1D from the tunnel wall are the most intensive and are mainly concentrated near the heading face, the side wall, and the left spandrel. At the construction site, the accuracy rate of rockburst prediction is 61.8%, of which the accuracy rate of the medium and strong rockburst is 80.3%. Based on field statistics of rockburst, the increase of the tunnel excavation section size can reduce the rockburst strength to a certain extent, which is consistent with the numerical simulation results.
Yeast Biotechnology 2.0
Authors: Willaert Ronnie G.
Published: November 2018

Yeast biotechnology. [...]
Segmental and Tandem Duplications Driving the Recent NBS-LRR Gene Expansion in the Asparagus Genome
Authors: Die Jose V. , Castro Patricia , Millán Teresa , Gil Juan
Published: November 2018

Garden asparagus is an important horticultural plant worldwide. It is, however, susceptible to a variety of diseases, which can affect the potential yield, spear quality, and lifespan of production fields. Screening studies have identified resistant germplasm. The genetic resistance is usually complex, and the genes underlying that resistance are still unknown. Most often, disease resistance is determined by resistance genes (R). The most predominant R-genes contain nucleotide binding site and leucine-rich repeat (NBS-LRR) domains. Using bioinformatics and data mining approaches, we identified and characterized 68 NBS predicted proteins encoded by 49 different loci in the asparagus genome. The NBS-encoding genes were grouped into seven distinct classes based on their domain architecture. The NBS genes are unevenly distributed through the genome and nearly 50% of the genes are present in clusters. Chromosome 6 is significantly NBS-enriched and one single cluster hosts 10% of the genes. Phylogenetic analysis points to their diversification into three families during their evolution. Recent duplications are likely to have dominated the NBS expansion with both tandem genes and duplication events across multiple chromosomes. Transcriptome sequencing data provided evidence for their transcription and tissue-specific expression. The total number of cis-regulatory elements as well as their relative positions within the NBS promoters suggests a complex transcriptional network regulating defense responses. Our study provides a strong groundwork for the isolation of candidate R-genes in garden asparagus.
Surface Level Synthetic Ground Motions for M7.6 2001 Gujarat Earthquake
Authors: Vemuri Jayaprakash , Kolluru Subramaniam , Chopra Sumer
Published: November 2018

The 2001 Gujarat earthquake was one of the most destructive intraplate earthquakes ever recorded. It had a moment magnitude of M w 7.6 and had a maximum felt intensity of X on the Modified Mercalli Intensity scale. No strong ground motion records are available for this earthquake, barring PGA values recorded on structural response recorders at thirteen sites. In this paper, synthetic ground motions are generated at surface level using the stochastic finite-fault method. Available PGA data from thirteen stations are used to validate the synthetic ground motions. The validated methodology is extended to various sites in Gujarat. Response spectra of synthetic ground motions are compared with the prescribed spectra based on the seismic zonation given in the Indian seismic code of practice. Ground motion characteristics such as peak ground acceleration, peak ground velocity, frequency content, significant duration, and energy content of the ground motions are analyzed. Response spectra of ground motions for towns situated in the highest zone, seismic zone 5, exceeded the prescribed spectral acceleration of 0.9 g for the maximum considered earthquake. The response spectra for towns in seismic zone 5 exhibit peaks in the low period ranges, indicating high vulnerability of low rise structures designed as per the provisions of the Indian seismic code of practice. The response spectra for towns situated in seismic zone 3 were considerably lower than the prescribed maximum spectral acceleration of 0.4 g. The substantial damage reported in towns situated in seismic zone 3 is due to poor construction practices and non-compliance with provisions of seismic design standards.
Geochemical Anomalies of Frozen Ground due to Hydrocarbon Migration in West Siberian Cryolithozone
Authors: Kurchatova Anna , Rogov Victor , Taratunina Natalia
Published: November 2018

According to the study of frozen deposits in the territory south of the Taz Peninsula, geochemical processes are considered under the hydrocarbon migration from the lower productive complex. An analysis of the cryolithological structure of the frozen stratum was performed, and the composition of the gas and authigenic associations was studied. It was shown that the migration of gases is caused by shear deformations with the formation of cryogenic textures with the presence of gas-bearing ice crystallites on slip surfaces. It was found that the migration of hydrocarbons causes significant local changes in pH/Eh parameters in the frozen stratum and determines the micromosaic distribution of sulfate and iron reduction processes that lead to the formation (including microbiological processes) of various forms of iron: sulphides, carbonates and oxides.
Impact of Water Deficit during Fruit Development on Quality and Yield of Young Table Grape Cultivars
Authors: Weiler Carolin Susanne , Merkt Nikolaus , Graeff-Hönninger Simone
Published: November 2018

Water limitation has a major effect on agricultural crop production, influencing yield as well as external and internal quality parameters of table grapes. Due to their high yield potential, table grapes have a particularly high risk for yield and quality losses when water is limited, but grapevines are known for high heterogeneity within cultivars. Therefore, we investigated the effect of prolonged water deficits (control, moderate, and severe deficit) during fruit development on yield and quality parameters of four different table grape cultivars (Vitis L.). Furthermore, we ranked their suitability for cultivation in areas suffering from water limitation. Up to 31% of irrigation water could be saved in comparison to the control, without significant negative effects on plant yield, berry size, or internal quality parameters, such as total soluble solids and total phenolic content. However, single bunch yield was highest at a moderate deficit and number of seeds in berries increased with the severity of deficit. Cultivar selection had the greatest influence on water consumption and mainly defined yield and quality parameters. The cultivar ‘Fanny’ produced the highest yields (195.17 g per plant), most bunches per plant (2.04), and biggest berries while cv. ‘Nero’ had the highest total soluble solids content (26.33 °Brix) and the highest total phenolic content (67.53 mg gallic acid equivalents per 100 g fresh weight). Overall, ‘Fanny’ was the most promising cultivar for cultivation under water-limited conditions during fruit development, without significant effects on yield and quality parameters.
Postharvest Treatments with GRAS Salts to Control Fresh Fruit Decay
Authors: Palou Lluís
Published: November 2018

Control of postharvest diseases of fresh fruits has relied for many years on the continuous use of conventional chemical fungicides. However, nonpolluting alternatives are increasingly needed because of human health and environmental issues related to the generation of chemical residues. Low-toxicity chemicals classified as food preservatives or as generally recognized as safe (GRAS) compounds have known and very low toxicological effects on mammals and minimal impact on the environment. Among them, inorganic or organic salts such as carbonates, sorbates, benzoates, silicates, etc., show significant advantages for potential commercial use, such as their availability, low cost, and general high solubility in water. Typically, these substances are first evaluated in vitro against target pathogens that cause important postharvest diseases. Selected salts and concentrations are then assayed as aqueous solutions in in vivo tests with target fresh fruit. Laboratory and small-scale experiments are conducted with fruit artificially inoculated with pathogens, whereas naturally infected fruit are used for large-scale, semicommercial, or commercial trials. Another approach that is increasingly gaining importance is evaluating GRAS salts as antifungal ingredients of novel synthetic edible coatings. These coatings could replace the fungicide-amended commercial waxes applied to many fruit commodities and could be used for organic or “zero-residue” fresh fruit production systems.
Automation for Water and Nitrogen Deficit Stress Detection in Soilless Tomato Crops Based on Spectral Indices
Authors: Elvanidi Angeliki , Katsoulas Nikolaos , Kittas Constantinos
Published: November 2018

Water and nitrogen deficit stress are some of the most important growth limiting factors in crop production. Several methods have been used to quantify the impact of water and nitrogen deficit stress on plant physiology. However, by performing machine learning with hyperspectral sensor data, crop physiology management systems are integrated into real artificial intelligence systems, providing richer recommendations and insights into implementing appropriate irrigation and environment control management strategies. In this study, the Classification Tree model was used to group complex hyperspectral datasets in order to provide remote visual results about plant water and nitrogen deficit stress. Soilless tomato crops are grown under varying water and nitrogen regimes. The model that we developed was trained using 75% of the total sample dataset, while the rest (25%) of the data were used to validate the model. The results showed that the combination of MSAVI, mrNDVI, and PRI had the potential to determine water and nitrogen deficit stress with 89.6% and 91.4% classification accuracy values for the training and testing samples, respectively. The results of the current study are promising for developing control strategies for sustainable greenhouse production.
Characterization of Gene Families Encoding Beta-Lactamases of Gram-Negative Rods Isolated from Ready-to-Eat Vegetables in Mexico City
Authors: Vázquez-López Rosalino , Solano-Gálvez Sandra , León-Chávez Bertha A. , Thompson-Bonilla María R. , Guerrero-González Tayde , Gómez-Conde Eduardo , Martínez-Fong Daniel , González-Barrios Juan A.
Published: November 2018

Beta-lactam resistant bacteria, which are commonly resident in tertiary hospitals, have emerged as a worldwide health problem because of ready-to-eat vegetable intake. We aimed to characterize the genes that provide resistance to beta-lactam antibiotics in Enterobacteriaceae, isolated from five commercial salad brands for human consumption in Mexico City. In total, twenty-five samples were collected, grown in blood agar plates, and the bacteria were biochemistry identified and antimicrobial susceptibility testing was done. The carried family genes were identified by endpoint PCR and the specific genes were confirmed with whole genome sequencing (WGS) by Next Generation Sequencing (NGS). Twelve positive cultures were identified and their microbiological distribution was as follows: 8.3% for Enterobacter aerogene (n = 1), 8.3% for Serratia fonticola (n = 1), 16.7% for Serratia marcesens (n = 2), 16.7% for Klebsiella pneumoniae (n = 2), and 50% (n = 6) for Enterobacter cloacae. The endpoint PCR results showed 11 colonies positive for blaBIL (91.7%), 11 for blaSHV (91.7%), 11 for blaCTX (97.7%), 12 for blaDHA (100%), four for blaVIM (33.3%), two for blaOXA (16.7%), two for blaIMP (16.7%), one for blaKPC (8.3%), and one for blaTEM (8.3%) gen; all samples were negative for blaROB, blaCMY, blaP, blaCFX and blaLAP gene. The sequencing analysis revealed a specific genotype for Enterobacter cloacae (blaSHV-12, blaCTX-M-15, blaDHA-1, blaKPC-2); Serratia marcescens (blaSHV-1, blaCTX-M-3, blaDHA-1, blaVIM-2); Klebsiella pneumoniae (blaSHV-12, blaCTX-M-15, blaDHA-1); Serratia fonticola (blaSHV-12, blaVIM-1, blaDHA-1); and, Enterobacter aerogene (blaSHV-1, blaCTX-M-1, blaDHA-1, blaVIM-2, blaOXA-9). Our results indicate that beta-lactam-resistant bacteria have acquired integrons with a different number of genes that provide pan-resistance to beta-lactam antibiotics, including penicillins, oxacillins, cefalosporins, monobactams, carbapenems, and imipenems.
In Silico Profiling of Clinical Phenotypes for Human Targets Using Adverse Event Data
Authors: Soldatos Theodoros G. , Taglang Guillaume , Jackson David B.
Published: November 2018

We present a novel approach for the molecular transformation and analysis of patient clinical phenotypes. Building on the fact that drugs perturb the function of targets/genes, we integrated data from 8.2 million clinical reports detailing drug-induced side effects with the molecular world of drug-target information. Using this dataset, we extracted 1.8 million associations of clinical phenotypes to 770 human drug-targets. This collection is perhaps the largest phenotypic profiling reference of human targets to-date, and unique in that it enables rapid development of testable molecular hypotheses directly from human-specific information. We also present validation results demonstrating analytical utilities of the approach, including drug safety prediction, and the design of novel combination therapies. Challenging the long-standing notion that molecular perturbation studies cannot be performed in humans, our data allows researchers to capitalize on the vast tomes of clinical information available throughout the healthcare system.
Oxidative Stress as Cause, Consequence, or Biomarker of Altered Female Reproduction and Development in the Space Environment
Authors: Steller Jon G. , Alberts Jeffrey R. , Ronca April E.
Published: November 2018

Oxidative stress has been implicated in the pathophysiology of numerous terrestrial disease processes and associated with morbidity following spaceflight. Furthermore, oxidative stress has long been considered a causative agent in adverse reproductive outcomes. The purpose of this review is to summarize the pathogenesis of oxidative stress caused by cosmic radiation and microgravity, review the relationship between oxidative stress and reproductive outcomes in females, and explore what role spaceflight-induced oxidative damage may have on female reproductive and developmental outcomes.
Indefinite Article + Possessive + Noun in Spanish: A Case of Refunctionalization?
Authors: Pato Enrique
Published: November 2018

The phenomenon under discussion is an example of a grammatical change that can be explained by refunctionalization, and as such, can be understood as the acquisition of a new meaning by an ‘endangered’ grammatical construction, which is reassigned to express another value. Refunctionalization involves the development of a new function (in this case a syntactic-semantic one). When an item loses its function, or is marginal within a system, it can be lost (as happens with the construction under study in Standard Spanish), it can be ‘saved’ as a marginal element (as in some areas of American Spanish varieties) or it can be reused for other purposes (as in the Central American Spanish varieties). The latter case presents new discursive values. Hence, this construction should be understood as an example of reusing grammatical functionally opaque material for new purposes.
On the History of Ante(s): Exaptation of Adverbial –s?
Authors: Nieuwenhuijsen Dorien
Published: November 2018

In this paper we will describe the historical development of the Spanish doublet ante-antes (‘before’) and explore the question whether a process of exaptation is involved (cf. Lass 1990). We will argue that the final –s of antes, that originally marked the adverbial status of the word, in the course of time had become a kind of morphological ‘junk’ (cf. Lass 1990) and, subsequently, could be exploited in order to encode the semantic opposition between temporal meaning on the one hand, and adversative meaning on the other hand. However, based on quantitative data we will show that the incipient semantic redistribution over the course of the 16th century rather suddenly collapsed, leading to a differentiation between the prepositional ante and adverbial antes.
N-[2-(1H-Indol-3-yl)ethyl]-2-(4-isobutylphenyl)propanamide
Authors: Manolov Stanimir , Ivanov Iliyan , Voynikov Yulian
Published: November 2018

The compound in the title was prepared by reaction between tryptamine and ibuprofen using N,N′-dicyclohexylcarbodiimide as a “dehydrating” reagent. The structure of the newly synthesized compound was determined by nuclear magnetic resonance (NMR) (1H-NMR and 13C-NMR), UV, IR, and mass spectral data.
Diamagnetism of Bulk Graphite Revised
Authors: Semenenko Bogdan , Esquinazi Pablo D.
Published: November 2018

Recently published structural analysis and galvanomagnetic studies of a large number of different bulk and mesoscopic graphite samples of high quality and purity reveal that the common picture assuming graphite samples as a semimetal with a homogeneous carrier density of conduction electrons is misleading. These new studies indicate that the main electrical conduction path occurs within 2D interfaces embedded in semiconducting Bernal and/or rhombohedral stacking regions. This new knowledge incites us to revise experimentally and theoretically the diamagnetism of graphite samples. We found that the c-axis susceptibility of highly pure oriented graphite samples is not really constant, but can vary several tens of percent for bulk samples with thickness t ≳ 30 μm, whereas by a much larger factor for samples with a smaller thickness. The observed decrease of the susceptibility with sample thickness qualitatively resembles the one reported for the electrical conductivity and indicates that the main part of the c-axis diamagnetic signal is not intrinsic to the ideal graphite structure, but it is due to the highly conducting 2D interfaces. The interpretation of the main diamagnetic signal of graphite agrees with the reported description of its galvanomagnetic properties and provides a hint to understand some magnetic peculiarities of thin graphite samples.
Nile Tilapia Derived Antimicrobial Peptide TP4 Exerts Antineoplastic Activity Through Microtubule Disruption
Authors: Ting Chen-Hung , Liu Yi-Chung , Lyu Ping-Chiang , Chen Jyh-Yih
Published: November 2018

Some antimicrobial peptides (AMPs) exhibit anti-cancer activity, acting on cancer cells either by causing membrane lysis or via intracellular effects. While intracellular penetration of AMPs has been shown to cause cancer cell death, the mechanisms of toxicity remain largely unknown. Here we show that a tilapia-derived AMP, Tilapia piscidin (TP) 4, penetrates intracellularly and targets the microtubule network. A pull-down assay identified α-Tubulin as a major interaction partner for TP4, and molecular docking analysis suggested that Phe1, Ile16, and Arg23 on TP4 are required for the interaction. TP4 treatment in A549 cells was found to disrupt the microtubule network in cells, and mutation of the essential TP4 residues prevented microtubule depolymerization in vitro. Importantly, the TP4 mutants also showed decreased cytotoxicity in A549 cells, suggesting that microtubule disruption is a major mechanistic component of TP4-mediated death in lung carcinoma cells.
Flavonoids from Nelumbo nucifera Gaertn., a Medicinal Plant: Uses in Traditional Medicine, Phytochemistry and Pharmacological Activities
Authors: Tungmunnithum Duangjai , Pinthong Darawan , Hano Christophe
Published: November 2018

Nelumbo nucifera Gaertn. has been used as an important ingredient for traditional medicines since ancient times, especially in Asian countries. Nowadays, many new or unknown phytochemical compounds from N. nucifera are still being discovered. Most of the current research about pharmacological activity focus on nuciferine, many other alkaloids, phenolic compounds, etc. However, there is no current review emphasizing on flavonoids, which is one of the potent secondary metabolites of this species and its pharmacological activities. Therefore, following a taxonomic description, we aim to illustrate and update the diversity of flavonoid phytochemical compounds from N. nucifera, the comparative analysis of flavonoid compositions and contents in various organs. The uses of this species in traditional medicine and the main pharmacological activities such as antioxidant, anti-inflammatory, anti-diabetic, anti-obesity, anti-angiogenic and anti-cancer activities are also illustrated in this works.
Cyano-Bridged Cu-Ni Coordination Polymer Nanoflakes and Their Thermal Conversion to Mixed Cu-Ni Oxides
Authors: Azhar Alowasheeir , Young Christine , Kaneti Yusuf Valentino , Yamauchi Yusuke , Badjah Ahmad Yacine , Naushad Mu , Habila Mohamed , Wabaidur Saikh , Alothman Zeid A. , Kim Jeonghun
Published: November 2018

Herein, we demonstrate the bottom-up synthesis of 2D cyano-bridged Cu-Ni coordination polymer (CP) nanoflakes through a controlled crystallization process and their conversion to Cu-Ni mixed oxides via a thermal treatment in air. The chelating effect of citrate anions effectively prevents the rapid coordination reaction between Cu2+ and K2[Ni(CN)4], resulting in the deceleration of the crystallization process of CPs. Specifically, with addition of trisodium citrate dehydrate, the number of nuclei formed at the early stage of the reaction is decreased. Less nuclei undergo a crystal growth by interacting with [Ni(CN)4]2−, leading to the formation of larger Cu-Ni CP nanoflakes. Following heat treatment in air, the -CN- groups present within the CP nanoflakes are removed and nanoporous Cu-Ni mixed oxide nanoflakes are generated. When tested as an electrode material for supercapacitors using a three-electrode system, the optimum Cu-Ni mixed oxide sample shows a maximum specific capacitance of 158 F g−1 at a current density of 1 A g−1. It is expected that the proposed method will be useful for the preparation of other types of 2D and 3D CPs as precursors for the creation of various nanoporous metal oxides.
Herpes Simplex Virus 1 Deregulation of Host MicroRNAs
Authors: Cokarić Brdovčak Maja , Zubković Andreja , Jurak Igor
Published: November 2018

Viruses utilize microRNAs (miRNAs) in a vast variety of possible interactions and mechanisms, apparently far beyond the classical understanding of gene repression in humans. Likewise, herpes simplex virus 1 (HSV-1) expresses numerous miRNAs and deregulates the expression of host miRNAs. Several HSV-1 miRNAs are abundantly expressed in latency, some of which are encoded antisense to transcripts of important productive infection genes, indicating their roles in repressing the productive cycle and/or in maintenance/reactivation from latency. In addition, HSV-1 also exploits host miRNAs to advance its replication or repress its genes to facilitate latency. Here, we discuss what is known about the functional interplay between HSV-1 and the host miRNA machinery, potential targets, and the molecular mechanisms leading to an efficient virus replication and spread.
Brain Iron Homeostasis: A Focus on Microglial Iron
Authors: Nnah Israel C. , Wessling-Resnick Marianne
Published: November 2018

Iron is an essential trace element required for important brain functions including oxidative metabolism, synaptic plasticity, myelination, and the synthesis of neurotransmitters. Disruptions in brain iron homeostasis underlie many neurodegenerative diseases. Increasing evidence suggests that accumulation of brain iron and chronic neuroinflammation, characterized by microglia activation and secretion of proinflammatory cytokines, are hallmarks of neurodegenerative disorders including Alzheimer’ s disease. While substantial efforts have led to an increased understanding of iron metabolism and the role of microglial cells in neuroinflammation, important questions still remain unanswered. Whether or not increased brain iron augments the inflammatory responses of microglial cells, including the molecular cues that guide such responses, is still unclear. How these brain macrophages accumulate, store, and utilize intracellular iron to carry out their various functions under normal and disease conditions is incompletely understood. Here, we describe the known and emerging mechanisms involved in microglial cell iron transport and metabolism as well as inflammatory responses in the brain, with a focus on AD.
Quantum Discontents, or What Is Wrong with Our Science Practice
Authors: Shkliarevsky Gennady
Published: November 2018

For more than eighty years, quantum theory (QT) has dominated physical science. This domination remains unchallenged to this day. Some physicists celebrate this remarkable stability. Others lament this fact and argue that QT inhibits our understanding of physical reality. They feel that numerous problems that have accumulated in physical science require stepping beyond the horizon outlined by QT. The article offers a critical examination of the foundational assumptions of QT that shape its practice. It uses two interpretations of QT as case studies—Copenhagen interpretation and the theoretical perspective advanced by American physicist David Bohm—to explain one major problem that continues to plague our study of physics. The article sketches a path to a possible solution and outlines a new science practice that this solution will require.
Sodium Hydroxide-Free Soy Protein Isolate-Based Films Crosslinked by Pentaerythritol Glycidyl Ether
Authors: Wu Yingji , Cai Liping , Wang Chen , Mei Changtong , Shi Sheldon Q.
Published: November 2018

The soy protein isolate (SPI), sodium dodecylbenzenesulfonate (SDBS) and pentaerythritol glycidyl ether (PEGE) were used to make biodegradable films in this study. Unlike the usual method that adding sodium hydroxide (NaOH) during the SPI-based film casting, SDBS was used as a surfactant playing the similar role as NaOH. Since NaOH is a chemical with corrosiveness and toxicity, the replacing of NaOH by SDBS might reduce the hazard threat during the utilization of SPI-based films in food packing application. Furthermore, the presentation of SDBS helped dispersing the hydrophobic PEGE into the hydrophilic SPI. PEGE is a crosslinking agent with multiple reactive epoxy groups. The chemical structures and micro morphologies of the fabricated films were investigated by means of FTIR, XRD, and SEM. The thermal stabilities of the films were examined by means of the thermo-gravimetric analysis. After the chemical crosslinking, the ultimate tensile strength of the film was significantly increased, meanwhile, the water absorption was dramatically decreased. It was concluded that the SPI-based film containing 4% PEGE achieved the optimal performance.
Preparation, Characterization, and Sludge Conditioning of Cationic Polyacrylamide Synthesized by a Novel UVA-Initiated System
Authors: Guan Qingqing , Zhu Guocheng , Liao Yi , Xu Jin , Sun Xiaoxu , Tian Fang , Xu Jiaxing , Luo Minghan
Published: November 2018

Controlling the concentration of free radicals in polymerization systems is advantageous for preparing cationic polyacrylamide (CPAM) with a high molecular weight and acceptable dissolvability. In this study, a novel ultraviolet (UVA)-initiated system characterized by an adjustable light intensity and a redox-azo complex initiator was used to synthesize a CPAM flocculant named NP. Comparatively, another CPAM flocculant named SP with a stable UVA light intensity and a single initiator was prepared. Their chemical structure, morphology, and thermal stability were analyzed through instrumental analysis. 1H NMR indicated that NP was successfully prepared, and a small fraction of a cationic homopolymer was mixed in the product. Polymerization conditions of NP were optimized, and polymerization mechanism was determined by investigating the effects of various parameters on intrinsic viscosity, conversion, and dissolvability. Results showed that the best performance was obtained at indices of 0.45 wt‰ redox initiator concentration, 0.2 wt‰ azo initiator concentration, 40.0 wt% cationic monomer, 3 wt‰ urea, and first- and second-stage light intensities of 8.5 and 13 mW/cm2, respectively. The sludge conditioning performances of NP and SP were comparatively evaluated, and the mechanism was determined by examining sedimentation behavior and floc size distribution. High intrinsic viscosity, porous morphology structure, and mixed NP cationic homopolymer contributed to the improvement of sludge conditioning performance.
The Effect of Sex and Performance Level on Pacing in Duathlon
Authors: Nikolaidis Pantelis T. , Villiger Elias , Vancini Rodrigo L. , Rosemann Thomas , Knechtle Beat
Published: November 2018

The purpose of the present research was to study the effect of sex and performance on pacing in short (Run1-10 km, Bike-50 km and Run2-5 km) and long distance (Run1-10 km, Bike-150 km and Run2-30 km) in the Powerman World Championship ‘Powerman Zofingen’. All finishers (n = 6671; women, n = 1037; men, n = 5634) competing either in the short or long distance versions of ‘Powerman Zofingen’ from 2003 to 2017 were analyzed for the time spent in each discipline (Run1, Bike and Run2), and in transition (Tran) from Run1 to Bike (Tran1) and from Bike to Run2 (Tran2). Athletes were ranked in quartile (Q) groups (Q1, Q2, Q3 and Q4), with Q1 the fastest and Q4 the slowest. In short distance, in both sexes, a medium discipline/transition × quartile interaction on relative time was observed (p < 0.001, η2p = 0.103 and η2p = 0.119, respectively), where Q1 was relatively the fastest in Tran1, Tran2 and Run2, and the slowest in Bike (p < 0.001). In long distance, in both sexes, a large discipline/transition × quartile interaction on relative time was observed (p < 0.001, η2p = 0.208 and η2p = 0.180, respectively), where Q1 was relatively the fastest in Tran1, Tran2 and Run2, and the slowest in Bike (p < 0.001). In summary, a similar trend of variation of pacing by performance level was observed in both sexes and distances with the fastest duathletes being the fastest in Run2 and both transitions, and the slowest in Bike.
A Microeconomic Methodology to Evaluate Energy Efficiency by Consumption Behaviors and Strategies to Improve Energy Efficiency
Authors: Xiang Zixia , Yin Yanhong , He Yuanwen
Published: November 2018

The present paper highlights a quantitative method to maximize energy efficiency based on the minimum energy consumption and maximum quality of life from consumption behaviors. Quality of life is expressed by utility, which is a Constant Elasticity of Substitution (CES) function of demands for composite goods, car trips and public transport trips. Individual energy consumption is estimated by the demand of goods and we applied this method to Nagasaki to evaluate energy efficiency. Our results showed that 28,154 kcal of energy is needed to support the life of one individual per day in Nagasaki. Furthermore, we found that 76% of energy was used for composite goods and 24% was used for mobility goods. To achieve maximum energy efficiency, our results highlight that energy should be reduced by increasing the consumption of composite goods and public transport trips, while simultaneously decreasing the consumption of car trips. Compared to residents in urban and suburban areas, individuals in Central Business Districts (CBD) were found to have higher energy efficiency. Findings in Nagasaki suggest three policy implications: First, eco-energy consumption patterns should be encouraged to decrease energy use, while maintaining quality of life. Second, mixed land use is attributed to increased energy efficiency. Lastly, the energy efficiency of mobility could be improved though increasing the attraction of public transport.
Impacts of Urbanization and Associated Factors on Ecosystem Services in the Beijing-Tianjin-Hebei Urban Agglomeration, China: Implications for Land Use Policy
Authors: Zhang Yushuo , Lu Xiao , Liu Boyu , Wu Dianting
Published: November 2018

Conflicts between ecological conservation and socio-economic development persisted over many decades in the Beijing–Tianjin–Hebei urban agglomeration (BTH). Ecosystem services were affected drastically by rapid urbanization and ecological restoration programs in the BTH since 2000. This study aims to identify the spatial patterns of the four types of ecosystem services (net primary productivity (NPP), crop production, water retention, and soil conservation) in 2000 and 2010, and to make clear the impacts of urbanization and associated factors on the spatial patterns of ecosystem services. Based on the quantification of ecosystem services, we assessed the spatial patterns and changes, and identified the relationships between the type diversity of ecosystem services and land-use change. We also analyzed the effect of the spatial differentiation of influencing factors on ecosystem services, using the geographical detector model. The results showed that the average value of crop production increased substantially between 2000 and 2010, whereas the net primary productivity decreased significantly, and the water retention and soil conservation decreased slightly. The ecosystem services exhibited a spatial similar to that of influencing factors, and the combination of any two factors strengthened the spatial effect more than a single factor. The geomorphic factors (elevation and slope) were found to control the distribution of NPP, water retention, and soil conservation. The population density was responsible for crop production. We also found that the urbanization rate plays a major indirect role in crop production and water retention when interacting with population density and slope, respectively. The normalized difference vegetation index (NDVI) indirectly influences the spatial distribution of NPP when interacting with geomorphic factors. These findings highlight the need to promote new strategies of land-use management in the BTH. On the one hand, it is necessary to carefully select where new urban land should be located in order to relieve the pressure on ecosystem services in dense urban areas. On the other hand, the maintenance of ecological restoration programs is needed for improving vegetation coverage in the ecological functional zones in the medium and long term.
An Overview of Shared Mobility
Authors: Machado Cláudia A. Soares , De Salles Hue Nicolas Patrick Marie , Berssaneti Fernando Tobal , Quintanilha José Alberto
Published: November 2018

In a wider understanding, shared mobility can be defined as trip alternatives that aim to maximize the utilization of the mobility resources that a society can pragmatically afford, disconnecting their usage from ownership. Then, shared mobility is the short-term access to shared vehicles according to the user’s needs and convenience. The contributions and added value of this paper are to provide an up-to-date and well-structured review on the area of shared mobility to researchers and practitioners of the transport sector. Hence, this paper presents a bibliographical review of shared mobility and its diverse modalities, as an alternative to individual transportation, especially in cases of individual automobiles or short trips restricted to an urban city. The present literature review on shared modes of transportation has discovered that the introduction of these modes alone will not solve transportation problems in large cities, with elevated and growing motorization rates. However, it can among the strategies employed to help alleviate the problems caused by traffic jams and pollution by reducing the number of vehicles in circulation, congestions, and the urban emission of polluting gases. Thus, the implementation of shared mobility schemes offers the potential to enhance the efficiency, competitiveness, social equity, and quality of life in cities. This paper covers the fundamental aspects of vehicle and/or ride sharing in urban centers, and provides an overview of current shared mobility systems.
Exploring Traffic Congestion on Urban Expressways Considering Drivers’ Unreasonable Behavior at Merge/Diverge Sections in China
Authors: Long Kejun , Lin Qin , Gu Jian , Wu Wei , Han Lee D.
Published: November 2018

The mechanisms of traffic congestion generation are more than complicated, due to complex geometric road designs and complicated driving behavior at urban expressways in China. We employ a cell transmission model (CTM) to simulate the traffic flow spatiotemporal evolution process along the expressway, and reveal the characteristics of traffic congestion occurrence and propagation. Here, we apply the variable-length-cell CTM to adapt the complicated road geometry and configuration, and propose the merge section CTM considering drivers’ mandatory lane-changing and other unreasonable behavior at the on-ramp merge section, and propose the diverge section CTM considering queue length end extending the expressway mainline to generate a dynamic bottleneck at the diverge section. In the new improved CTM model, we introduce merge ratio and diverge ratio to describe the effect of driver behavior at the merge and diverge section. We conduct simulations on the real urban expressway in China, with results showing that the merge section and diverge section are the original location of expressway traffic congestion generation, and on/off-ramp traffic flow has a great effect on the expressway mainline operation. When on-ramp traffic volume increases by 40%, the merge section delay increases by 35%, and when off-ramp capacity increases by 100 veh/hr, the diverge section delay decreases about by 10%, which proves the strong interaction between expressway and adjacent road networks. Our results provide the underlying insights of traffic congestion mechanism in urban expressway in China, which can be used to better understand and manage this issue.
Evaluating International Tourists’ Perceptions on Cultural Distance and Recreation Demand
Authors: Lee Chun-Hung , Chen Han-Shen , Liou Gwo-Bao , Tsai Bi-Kun , Hsieh Chi-Ming
Published: November 2018

This study employed the travel cost method (TCM) to establish the on-site Poisson model to measure differences in the recreation benefits of Chinese inbound tourists based on the identified cultural distance clusters. Four clusters among the extracted factors of delineated perceptions on cultural distance were identified through the cluster analysis. This study finds that: (1) among four identified cognitive factors of the cultural distance, “social environment” and “personal relationship” were found to be more important than “living arrangement” and “verbal communication” factors; (2) the four cultural distance clusters differ significantly in terms of perceptions on the cultural distance; (3) the economic benefits of culture and heritage tourism ranged between US$4733 to US$6740 for average annual Chinese visitor numbers to Taiwan; (4) the “similar living habits” cluster had higher recreation benefits than the other three cultural distance clusters. The government and travel industries should pay attention to target segments in order to enhance the cultural heritage experience, by delivering an appropriate quality of service to match visitors’ needs and living habits, which in turn, impacts their revisit intent.
On Protection of Intangible Cultural Heritage in China from the Intellectual Property Rights Perspective
Authors: Lin Qing , Lian Zheng
Published: November 2018

With the development of globalization, intangible cultural heritage (ICH) has come under increasing threat, making the safeguarding of ICH a crucial task for the governments and peoples of the world. This paper examines China’s current state of intellectual property (IPR) protection for ICH and proposes that ICH be placed under China’s legislative protection as intellectual property. Due to the immense diversity and complexity of ICH and the difficulty in reconciling various interests involved, the existing IPR protection mode faces many obstacles in practice. We present two case studies and three sets of recommendations on improving the protection of ICH in China. The first set relies on improving copyright protection for ICH, the second set relies on improving trademark and geographical protection for ICH, and the third set relies on improving patent protection for ICH.
Is It Correct to Use the Internal Rate of Return to Evaluate the Sustainability of Investment Decisions in Public Private Partnership Projects?
Authors: De Albornoz Vicente Alcaraz Carrillo , Galera Antonio Lara , Millán Juan Molina
Published: November 2018

Public Private Partnerships (PPP) are viewed by the private sector as investment projects. An investment criterion, such as the internal rate of return (IRR), widely used by practitioners, is thus necessary in order to determine if the opportunity is sustainable from an economic point of view and worth pursuing. However, a cash flow may have multiple IRRs—is it appropriate in the context of PPPs to use this criterion? This paper provides a clear proposition to determine the potential number of real positive IRRs a cash flow may have, depending on the number of sign variations and the value of the net present value (NPV) calculated with a discount rate equal to 0 (NPV(r = 0)). This proposition can sometimes be used when other tests (such as Norstrom’s Criterion) are inconclusive to determine if a cash flow has a single real positive IRR. The proposition is generally met by the typical cash flow of a PPP project, validating the use of IRR as an investment criterion.
Recycling of End-of-Life Vehicles in Small Islands: The Case of Kinmen, Taiwan
Authors: Lin Hsin-Tien , Nakajima Kenichi , Yamasue Eiji , Ishihara Keiichi N.
Published: November 2018

The abandoned end-of-life vehicle (ELV) problem in small islands has negative effects on local sustainable development, and the treatment of ELVs in island scale is usually difficult. This study presents the investigation of the material flows and economic analysis on the ELVs in small islands by the case study of Kinmen, Taiwan. The ELVs generation amount is estimated using the population balance model (PBM) and the results showed a steep increase in the future for both automobiles and motorcycles. The insufficient ELV treatment capacity has resulted in the significant informal treatment flow, which will be the total weight of 1906 tons of items with market value, with a potential economic gain of 16.9 million TWD in 2050. The results of the economic characterization of the local dismantling business clarified that profitability is the main hindrance for the development of new dismantling business due to high transportation costs. Our results suggested that implementation of the different subsidy rate according to the treatment area under the current policy or creation of a new treatment flow with a direct shipment of ELVs for treatment is necessary to improve the utilization of the stocked materials from untreated ELVs.