bluuebunny/crossref_metadata_2025 huggingface dataset:
Oxidative hemolysis of erythrocytes
Authors: Włodek Lidia , Kusior Dorota
Published: January 2007

This exercise for students will allow them to simultaneously observe lipid peroxidation and consequent hemolysis of rat erythrocytes and the effect of sodium azide, a catalase inhibitor, on these processes. It will also demonstrate a protective action of antioxidants, the therapeutically used N‐acetylcysteine and albumins present in plasma.
P‐Glycoprotein Inhibitory Activity of Two Phenolic Compounds, (−)‐Syringaresinol and Tricin from Sasa borealis
Authors: Jeong Yeon Hee , Chung Soo Yeon , Han Ah‐Reum , Sung Min Kyung , Jang Dae Sik , Lee Jun , Kwon Youngjoo , Lee Hwa Jeong , Seo Eun‐Kyoung
Published: January 2007

(−)‐Syringaresinol and tricin, isolated from the AcOEt‐soluble extract of the whole plants of Sasa borealis (Gramineae), showed inhibitory effects on the P‐glycoprotein in adriamycin‐resistant human breast cancer cells, MCF‐7/ADR.
Efficient Synthesis of Solasodine, O‐Acetylsolasodine, and Soladulcidine as Anticancer Steroidal Alkaloids
Authors: Zha Xiaoming , Sun Hongbin , Hao Jia , Zhang Yihua
Published: January 2007

An efficient synthesis of the steroidal alkaloids solasodine (1), O‐acetylsolasodine (2), and soladulcidine (3) starting from easily available diosgenin and tigogenin in five or six steps (overall yield 25, 24, and 28%, resp.) is described. Moreover, our synthetic route provides a selective modification at C(3) of 1 and related compounds in order to carry out lead optimization on these natural antitumor steroidal alkaloids.
A New Flavone Xyloside and Two New Flavan‐3‐ol Glucosides from Juniperus communis var. depressa
Authors: Iida Naoki , Inatomi Yuka , Murata Hiroko , Inada Akira , Murata Jin , Lang Frank A. , Matsuura Nobuyasu , Nakanishi Tsutomu
Published: January 2007

A new flavone xyloside, 1, and two new flavan‐3‐ol glucosides, 3 and 4, were isolated together with three known flavones, 2, 11, and 12, five known flavans, 5–9, and a known dihydrochalcone, 10, from the stems and leaves of Juniperus communis var. depressa (Cupressaceae) collected in Oregon, U.S.A., and their structures were determined on the basis of spectral evidence. A novel flavone nucleus such as that in 1 is seldom found in nature today, and new methylcatechin glucosides 3 and 4 are also rare in nature. In addition, we investigated the inhibitory activity of individual components, i.e., 8–11, and others, that were abundantly isolated from the same plant material for the Maillard reaction.
Synthesis and Biological Studies of N‐Alkylated Cyclic Diamines
Authors: Xiong Xiao‐Qin , Liang Feng , Yang Li , Zhou Xiang , Zheng Cong‐Yi , Cao Xiao‐Ping
Published: January 2007

Several alkyl‐substituted mesocyclic diamines were synthesized, and their interaction with DNA were studied by melting‐temperature measurements and the ethidium bromide (EB)‐fluorescence competitive method. The supercoiled DNA hydrolytic cleavage by 1,4‐dioctyl‐1,4‐diazepan‐6‐ol (4) was supported by the evidence from free‐radical quenching and T4‐ligase ligation. Preliminary pharmacological tests showed that only 1,4‐dioctyl‐1,4‐diazepan‐6‐ol (4) had antitumor activity against HeLa cell lines in vitro.
Controlling the Association of Adamantyl‐Substituted Poly{N‐[tris(hydroxymethyl)methyl]acrylamide} and a β‐Cyclodextrin/Epichlorohydrin Polymer by a Small Drug Molecule – Naproxen
Authors: Mislovičová Danica , Kogan Grigorij , Gosselet Noëlle Martine , Sébille Bernard , Šoltés Ladislav
Published: January 2007

Two polymeric substances, a poly{N‐[tris(hydroxymethyl)methyl]acrylamide} (THMMA) substituted with adamantyl moieties and a β‐cyclodextrin/epichlorohydrin polycondensate, formed a host–guest type complex, which resulted in the gel formation upon mixing of these two compounds at appropriate conditions. Introduction of a drug molecule, i.e., naproxen, that was able to fill the β‐cyclodextrin cavities, thus expulsing adamantyl moieties, led to disruption of such association and inhibition of gel formation. The conditions required for the association of the two polymeric components and formation of the gel, as well as the dynamics of its inhibition by addition of naproxen was established. The procedure of using solutions of two associating polymers and an appropriate drug competitor can be used at targeted viscosupplementation.
Chemistry, Urease Inhibition, and Phytotoxic Studies of Binuclear Vanadium(IV) Complexes
Authors: Ara Rifat , Ashiq Uzma , Mahroof‐Tahir Mohammad , Maqsood Zahida Tasneem , Khan Khalid Mohammed , Lodhi Muhammad Arif , Choudhary Muhammad Iqbal
Published: January 2007

Vanadium plays an important role in biological systems and exhibits a variety of bioactivities. In an effort to uncover the chemistry and biochemistry of vanadium with nitrogen‐ and oxygen‐containing ligands, we report herein the synthesis and spectroscopic characterization of vanadium(IV) complexes with hydrazide ligands. Substituents on these ligands exhibit systematic variations of electronic and steric factors. Elemental and spectral data indicate the presence of a dimeric unit with two vanadium(IV) ions coordinated with two hydrazide ligands along with two H2O molecules. The stability studies of these complexes over time in coordinating solvent, DMSO, indicates binding of the solvent molecules to give [V2O2L2(H2O)2(DMSO)2]2+ (L=hydrazide ligand) and then conversion of it to a monomeric intermediate species, [VOL(DMSO)3]1+. Hydrazide ligands are inactive against urease, whereas vanadium(IV) complexes of these ligands show significant inhibitory potential against this enzyme and are found to be non‐competitive inhibitors. These complexes also show low phytotoxicity indicating their usefulness for soil ureases. Structure–activity relationship studies indicate that the steric and/or electronic effects that may change the geometry of the complexes play an important role in their inhibitory potential and phytotoxicity.
A Novel Method for the Assessment of Methyl Parathion by Using Coupling Agents in Environmental and Commercial Samples
Authors: Nagaraja Padmarajaiah , Bhaskara Besagarahally L.
Published: January 2007

A sensitive and rapid spectrophotometric method for the determination of reduced methyl parathion (=O,O‐dimethyl O‐(4‐nitrophenyl) phosphorothioate) is described. The method is based on the interaction of diazotized reduced methyl parathion with 8‐hydroxyquinoline (=quinolin‐8‐ol; 8‐HQ) and 3‐aminophenol (3‐AP) as new coupling agents. Absorbances of the resulting chromophores are measured at 430 and 440 nm, respectively, and colored products were stable for at least 2 days. Beer's law is obeyed over the methyl parathion concentration range 0.2–5.5 μg ml−1 for 8‐HQ and 0.5–6.0 μg ml−1 for 3‐AP. From the data, it was confirmed that the two coupling agents can be effectively applied for the determination of methyl parathion in environmental and commercial samples.
Guaiane Sesquiterpene Lactones from Salvia nubicola (Lamiaceae)
Authors: Ali Muhammad S. , Ibrahim Syed A. , Ahmed Shakeel , Lobkovsky Emil
Published: January 2007

A new sesquiterpene lactone, nubiol (1), belonging to the guaiane class, along with a dimer, bisnubidiol (2), has been isolated from Salvia nubicola collected from Quetta, Pakistan. The structures of both metabolites were elucidated with the aid of spectroscopic techniques including 2D‐NMR. Additionally, the structure of nubiol (1) was finally confirmed via the single crystal X‐ray diffraction. Nubiol (1) was found moderately active against Pseudomonas aeruginosa.
Chemical Constituents of Plants from the Genus Symplocos
Authors: Huo Chang‐Hong , Shen Li‐Ru , Zhao Yu‐Ying , Liang Hong
Published: January 2007

The chemical constituents of Symplocos genus were reviewed with 90 structures and 28 references cited. These constituents include triterpenoids, flavonoids, lignans, phenols, steroids, alkaloids, and iridoids. Triterpenoids are the dominant constituents within the genus Symplocos, some of them exhibited antiproliferative effects. Some phenolic glycoside derivatives showed inhibitory activity against snake‐venom phosphodiesterase I and human nucleotide pyrophosphatase phosphodiesterase.
A Second Polymorph of [H3N(CH2)3NH3] [V4O10].
Authors: Stephens Nicholas F. , Lightfoot Philip
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Remnant Magnetization above Room Temperature in the Semiconductor Y0.5Ca0.5BaCo4O7.
Authors: Valldor Martin
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Two‐Step Novel Synthesis of 2‐Amino‐6‐ (1,3‐dioxo‐2,3‐dihydro‐1H‐inden‐2‐yl) ‐4,7‐diphenyloxepine‐3‐carbonitrile and 5‐(1,3‐Dioxo‐2,3‐dihydro‐1H‐inden‐2‐yl) ‐2‐imino‐6‐phenyl‐2H‐pyran‐3‐carbonitrile.
Authors: Elmaaty Tarek M. Abou
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Unexpected Formation of Bicyclic Cyclopropane Lactam and Pyridone from the Reaction of cis‐2‐Aryl‐1‐carbomethoxy‐3,3‐dicynocyclopropane with Primary Aliphatic Amine via Isomerization and Rearrangement.
Authors: Ren Zhongjiao , Cao Weiguo , Wang Sihui , Wang Yun , Lu Yeying
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Novel Bis‐Condensed Heterocyclic Ring Assembly Systems.
Authors: Sachar Anand , Sharma R. L. , Kumar Surinder , Kaur Daljeet , Singh Jasbir
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
KHSO4×H2O/SiO2‐Catalyzed, One‐Pot, Solvent‐Free Synthesis of Pyrazolines, Tetrahydrocarbozoles and Indoles Using Microwave Irradiation.
Authors: Kapoor Kamal K. , Ganai Bilal A. , Kumar Satish , Andotra Charanjeet S.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Methyltrioxorhenium and Sodium Bromide‐Catalyzed Oxidation of Alcohols to Carbonyl Compounds with H2O2 Using 1‐Butyl‐3‐methylimidazolium Tetrafluoroborate Ionic Liquid as a Novel Recyclable Green Solvent.
Authors: Jain Suman L. , Sharma Vishal B. , Sain Bir
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Oxidation of Benzylic Alcohols to Their Corresponding Carbonyl Compounds Using KIO4 in Ionic Liquid by Microwave Irradiation.
Authors: Hajipour Abdol Reza , Rafiee Fatemeh , Ruoho Arnold E.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Polyvinylpyridine as a Novel Solid Heterogeneous, Recyclable Catalyst for aza‐Michael Reaction.
Authors: Raje Vivek P. , Bhat Ramakrishna P. , Samant Shriniwas D.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Studies on the Allylation Reactions of Aldehydes and Ketones with Lanthanum in Water.
Authors: Bian Yan‐Jiang , Zhang Jian‐Qiang , Xia Jin‐Ping , Li Ji‐Tai
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Regioselective Rhodium‐Catalyzed Hydroformylation of Unsaturated Esters: The First Practical Method for Quaternary Selective Carbonylation.
Authors: Clarke Matthew L. , Roff Geoffrey J.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ion‐Supported Chiral Pyrrolidines as Enantioselective Catalysts for Direct Michael Addition of Nitroalkenes in [BMIm]PF6.
Authors: Xu Danqian , Luo Shuping , Yue Huadong , Wang Liping , Liu Yunkui , Xu Zhenyuan
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The First Catalytic Mannich‐Type Reaction of N‐Alkoxycarbonylamino Sulfones with Silyl Enolates.
Authors: Ollevier Thierry , Nadeau Etienne , Eguillon Jean‐Christophe
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Addition of Diethylzinc to Diphenylphosphinoyl‐Imines Catalyzed by Copper(II) Trifluoromethanesulfonate‐Chiral (2′‐Ethylamino‐[1,1′]binaphthalenyl‐2‐yl)‐thiophosphoramidic Acid O,O′‐Diaryl Ester Ligands.
Authors: Shi Min , Lei Zhi‐Yu , Xu Qin
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Simple and Eco‐Friendly Reduction of Nitroarenes to the Corresponding Aromatic Amines Using Polymer‐Supported Hydrazine Hydrate over Iron Oxide Hydroxide Catalyst.
Authors: Shi Qixun , Lu Rongwen , Jin Kun , Zhang Zhuxia , Zhao Defeng
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 1,1‐Dimethyl‐4‐indanol Derivatives.
Authors: Wang Yang , Wu Jiang , Xia Peng
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Optically Pure Terminal Epoxide and 1,2‐Diol via Hydrolytic Kinetic Resolution Catalyzed by New Heterometallic Salen Complexes.
Authors: Thakur Santosh Singh , Chen Shu‐Wei , Li Wenji , Shin Chang‐Kyo , Koo Yoon‐Mo , Kim Geon‐Joong
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of β,γ,γ‐Tri‐ or γ,γ‐Disubstituted α‐Methylene‐γ‐butyrolactones Starting from the Baylis—Hillman Adducts.
Authors: Lee Ka Young , Park Da Yeon , Kim Jae Nyoung
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rapid One‐Pot Preparation of 2‐Substituted Benzimidazoles from Esters Using Microwave Conditions.
Authors: Jing Xiaobi , Zhu Qihua , Xu Feng , Ren Xinfeng , Li Dong , Yan Chaoguo
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Mass Spectral Study of New Phenylsulfonyl Substituted Isoxazolidines.
Authors: Dueruest Yasar , Altug Cevher , Sinkkonen Jari , Martiskainen Olli , Pihlaja Kalevi
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Practical Synthesis of 5′‐(4′‐Methylbiphenyl‐2‐yl)‐1H‐tetrazole.
Authors: Kantevari Srinivas , Nair C. K. Snehalatha , Pardhasaradhi M.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
D,L‐α‐Tocopherol Synthesis Catalyzed by the Broensted Acidic Ionic Liquids.
Authors: Xing Huabing , Wang Tao , Zhou Zhenhuan , Dai Youyuan
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Biological Evaluation of 3‐Amino‐4‐aryl‐piperidine Derivatives as BACE 1 Inhibitors.
Authors: Lim Hee‐Jong , Jung Myung Hee , Lee Ihl Young Choi , Park Woo Kyu
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
α‐Cyclization of Tertiary Amines: Synthesis of Some Novel Anellated Quinolines via a Three‐Component Reaction under Solvent‐Free Conditions.
Authors: Devi Ipsita , Baruah Biswajita , Bhuyan Pulak J.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Antimony Chloride Doped on Hydroxyapatite Catalyzed Stereoselective One‐Pot Synthesis of Pyrano[3,2‐c]quinolines.
Authors: Mahajan Deepali , Ganai Bilal A. , Sharma Rattan Lal , Kapoor Kamal K.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Convenient Route for the Synthesis of Pyrazolo[3,4‐d]pyrimidine, Pyrazolo[3,4‐b][1,6]naphthyridine and Pyrazolo[3,4‐b]quinoline Derivatives.
Authors: Jachak Madhukar N. , Avhale Appasaheb B. , Medhane Vijay J. , Toche Raghunath B.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Anticonvulsant Activity of Some Potential Thiazolidinonyl 2‐Oxo/Thiobarbituric Acids.
Authors: Agarwal A. , Lata S. , Saxena K. K. , Srivastava V. K. , Kumar A.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hydrothermal Syntheses of Some Derivatives of Tetraazatriphenylene.
Authors: Che Guangbo , Li Wenlian , Kong Zhiguo , Su Zisheng , Chu Bei , Li Bin , Zhang Zhiqiang , Hu Zhizhi , Chi Haijun
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Substituted 4‐(3‐Alkyl‐1,2,4‐oxadiazol‐5‐ylmethyl)‐3,4‐dihydro‐2H‐1,4‐benzoxazines and 4‐(1H‐Benzimidazol‐2‐ylmethyl)‐3,4‐dihydro‐2H‐1,4‐benzoxazines.
Authors: Mizar Pushpak , Myrboh Bekington
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Singlet Oxygen Addition to Chiral Allylic Alcohols and Subsequent Peroxyacetalization with β‐Naphthaldehyde: Synthesis of Diastereomerically Pure 3‐β‐Naphthyl‐Substituted 1,2,4‐Trioxanes.
Authors: Griesbeck Axel G. , El‐Idreesy Tamer T. , Lex Johann
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Acridine Derivative as a Fluorescent Chemosensor for Zinc Ions in a 100% Aqueous Solution: A Comparison of Binding Property with Anthracene Derivative.
Authors: Park Min Sun , Swamy K. M. K. , Lee Yoon Ju , Lee Han Na , Jang Yun Jung , Moon Young Hyun , Yoon Juyoung
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Diversity‐Oriented Approach to Biologically Relevant Molecular Frameworks Starting with β‐Naphthol and Using the Claisen Rearrangement and Olefin Metathesis as Key Steps.
Authors: Kotha Sambasivarao , Mandal Kalyaneswar , Tiwari Arti , Mobin Shaikh M.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Work‐Up‐Free Deprotection of Borane Complexes of Phosphines, Phosphites, and Phosphinites with Polymer‐Supported Amines.
Authors: Sayalero Sonia , Pericas Miquel A.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Preparation of 2‐Amino‐1,3‐selenazoles by Reaction of N,N‐Unsubstituted Selenoureas with α,β‐Unsaturated Ketones in Alcohol.
Authors: Koketsu Mamoru , Kanoh Koichi , Ishihara Hideharu
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Vigabatrin®.
Authors: Chang Meng‐Yang , Lin Chun‐Yu , Ong Chi‐Wi
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Proteomorphous Objects from Abiotic Backbones.
Authors: Delsuc Nicolas , Leger Jean‐Michel , Massip Stephane , Huc Ivan
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Polymer‐Assisted Solution‐Phase Strategy for the Synthesis of Fused [2,1‐b]Quinazolinones and the Preparation of Optically Active Vasicinone (VIII).
Authors: Kamal Ahmed , Devaiah V. , Shankaraiah N. , Reddy K. Laxma
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Diverse Suite of Spiroacetals, Including a Novel Branched Representative, is Released by Female Bactrocera tryoni (Queensland Fruit Fly)
Authors: Booth Yvonne K. , Schwartz Brett D. , Fletcher Mary T. , Lambert Lynette K. , Kitching William , De Voss James J.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel Antiproliferative Agent, Phenylpyridineylbutenol, Isolated from Streptomyces sp.
Authors: Shin Choonshik , Lim Haeyoung , Moon Sangik , Kim Seunghyun , Yong Yeonjoong , Kim Bum‐Joon , Lee Chul‐Hoon , Lim Yoongho
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Impact of Tautomer Forms on Pharmacophore‐Based Virtual Screening.
Authors: Oellien Frank , Cramer Joerg , Beyer Carsten , Ihlenfeldt Wolf‐Dietrich , Selzer Paul M.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Learning from the Data: Mining of Large High‐Throughput Screening Databases.
Authors: Yan S. Frank , King Frederick J. , He Yun , Caldwell Jeremy S. , Zhou Yingyao
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
SemanticEye: A Semantic Web Application to Rationalize and Enhance Chemical Electronic Publishing.
Authors: Casher Omer , Rzepa Henry S.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Substructure‐Based Support Vector Machine Classifiers for Prediction of Adverse Effects in Diverse Classes of Drugs.
Authors: Bhavani S. , Nagargadde A. , Thawani A. , Sridhar V. , Chandra N.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Fabrication of Rod‐Like CeO2: Characterization, Optical and Electrochemical Properties.
Authors: Zhang Dong‐En , Ni Xiao‐Min , Zheng Hua‐Gui , Zhang Xiao‐Jun , Song Ji‐Mei
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ruthenium Compounds
Authors: Angaridis Panagiotis
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Technetium Compounds
Authors: Sattelberger Alfred P.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Intramolecular Reductive Cyclizations Using Electrochemistry: Development of Environmentally Friendly Synthetic Methodologies
Authors: Dunach Elisabet , Medeiros Maria Jose , Olivero Sandra
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Heterocyclization Reactions with Fischer Carbene Complexes
Authors: Barluenga Jose , Martinez Silvia
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cobalt and Palladium Reagents in Organic Synthesis: The Beginning
Authors: Heck Richard F.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Peptide Nucleic Acids (PNAs)
Authors: Shakeel Shabih , Karim Sajjad , Ali Arif
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Recent Developments in Epoxide Preparation
Authors: Sello G. , Fumagalli Tiziano , Orsini F.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemistry of Cubane and Other Prismanes
Authors: Bashir‐Hashemi A.
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Thioureas and Selenoureas and Their Applications
Authors: Koketsu Mamoru , Ishihara Hideharu
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Biocatalytic Reduction of Carbonyl Groups
Authors: Nakamura Kaoru , Matsuda Tomoko
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Lithium Amides
Authors: Eames Jason
Published: January 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Chemieschulbücher in der Unterrichtsplanung ‐ Welche Bedeutung haben Schülervorstellungen?
Authors: Beerenwinkel Anne , Parchmann Ilka , Gräsel Cornelia
Published: January 2007

Das konstruktivistische Modell des Wissenserwerbs stellt Lernen als einen aktiven, zielgerichteten Prozess dar. Das Vorwissen des Einzelnen beeinflusst grundlegend, welche Informationen wahrgenommen und wie sie interpretiert werden. Auch im naturwissenschaftlichen Bereich bringen Schüler viele Vorstellungen mit in den Unterricht, die nicht mit den wissenschaftlichen übereinstimmen. Ein Nichtaufgreifen dieser Ideen kann zu Lernschwierigkeiten führen [z.B. 1, 2]. In diesem Zusammenhang stellt sich die Frage, wie Ergebnisse der Forschung zu Schülervorstellungen in die Praxis umgesetzt werden können. Einen Ansatzpunkt bieten hier Medien, die Lehrkräfte für ihre Unterrichtsplanung verwenden. Eines der wichtigsten Medien für die Vorbereitung im Fach Chemie ist nach einer Untersuchung von Daus et al. [3] das Schulbuch. Dies deckt sich mit den Ergebnissen einer eigenen Befragung von Chemielehrkräften, die wir 2004 durchführten. In einer qualitativen Analyse wurde daraufhin exemplarisch anhand der Thematik „Teilchenmodell”︁ untersucht, inwieweit bekannte Fehlkonzepte in Chemieschulbüchern aufgegriffen werden. Die Ergebnisse der Lehrerbefragung und der Schulbuchanalyse werden im folgenden Beitrag vorgestellt und diskutiert. Abschließend werden Beispiele aus einem Kriterienraster für eine bessere Integration von Schülervorstellungen in Lehrtexte vorgestellt.
Direct Coupling of Bromine‐Mediated Methane Activation and Carbon‐Deposit Gasification
Authors: Osterwalder Neil , Stark Wendelin J.
Published: January 2007

The direct bromination of methane offers a quite selective (>98 %) route towards methane activation but shifts the problem of fuel production to converting and handling corrosive methyl bromide. The direct conversion of methyl bromide, at about 200 °C, into light hydrocarbons can be catalyzed under pressure by AlBr3 resulting in the formation of propane‐rich mixtures of light hydrocarbons, carbonaceous deposits, and HBr. After releasing the gaseous products, the addition of hydrogen at 260 °C allows a quantitative conversion of the carbonaceous deposits into the same range of light hydrocarbons. These second‐stage products efficiently contribute to the overall process yield while enabling a full regeneration of the catalyst′s activity. This oxygen‐free process is compared to the conversion of methyl bromide on zeolites and the currently used methanol‐to‐gasoline (MTG) process in terms of product distributions and apparent energy of activation. A detailed chemical analysis of the intermediates revealed the presence of a carbon pool consisting of highly substituted benzene and cyclopentadiene derivatives, as observed on zeolites used in the MTG process. This similarity suggests that the currently used oxygen‐based syngas/MTG process for methane conversion may be extended to a bromine‐mediated process by using methyl bromide as an intermediate instead of methanol.
Cathepsin D gene expression outlines the areas of physiological cell death during embryonic development
Authors: Zuzarte‐Luis V. , Montero J.A. , Torre‐Perez N. , Garcia‐Porrero J.A. , Hurle J.M.
Published: January 2007

The implication of lysosomes in the activation of physiological cell death (PCD) was proposed some decades ago. In this work, we show that the expression of the lysosomal enzyme cathepsin D is up‐regulated in developing tissues undergoing apoptosis. By comparing vital and terminal deoxynucleotidyl transferase–mediated deoxyuridinetriphosphate nick end‐labeling (TUNEL) labeling patterns with in situ hybridization for this gene in a variety of tissues and organs, we show that this procedure constitutes a reliable technique to map the regions of PCD in the embryo. Using this methodological approach, we report the occurrence of two new areas of PCD in the developing limb. Developmental Dynamics 236:880–885, 2007. © 2007 Wiley‐Liss, Inc.
Hepatic HNF4α deficiency induces periportal expression of glutamine synthetase and other pericentral enzymes
Authors: Stanulović Vesna S. , Kyrmizi Irene , Kruithof-de Julio Marianna , Hoogenkamp Maarten , Vermeulen Jacqueline L. M. , Ruijter Jan M. , Talianidis Iannis , Hakvoort Theodorus B. M. , Lamers Wouter H.
Published: January 2007

In liver, most genes are expressed with a porto-central gradient. The transcription factor hepatic nuclear-factor4α (HNF4α) is associated with 12% of the genes in adult liver, but its involvement in zonation of gene expression has not been investigated. A putative HNF4α-response element in the upstream enhancer of glutamine synthetase (GS), an exclusively pericentral enzyme, was protected against DNase-I and interacted with a protein that is recognized by HNF4α-specific antiserum. Chromatin-immunoprecipitation assays of HNF4α-deficient (H4LivKO) and control (H4Flox) livers with HNF4α antiserum precipitated the GS upstream enhancer DNA only from H4Flox liver. Identical results were obtained with a histone-deacetylase1 (HDAC1) antibody, but antibodies against HDAC3, SMRT and SHP did not precipitate the GS upstream enhancer. In H4Flox liver, GS, ornithine aminotransferase (OAT) and thyroid hormone-receptor β1 (TRβ1) were exclusively expressed in pericentral hepatocytes. In H4LivKO liver, this pericentral expression remained unaffected, but the genes were additionally expressed in the periportal hepatocytes, albeit at a lower level. The expression of the periportal enzyme phosphoenolpyruvate carboxykinase had declined in HNF4α-deficient hepatocytes. GS-negative cells, which were present as single, large hepatocytes or as groups of small cells near portal veins, did express HNF4α. Clusters of very small GS- and HNF4α-negative, and PCNA- and OV6-positive cells near portal veins were contiguous with streaks of brightly HNF4α-positive, OV6-, PCNA-, and PEPCK-dim cells.

Conclusion:

Our findings show that HNF4α suppresses the expression of pericentral proteins in periportal hepatocytes, possibly via a HDAC1-mediated mechanism. Furthermore, we show that HNF4α deficiency induces foci of regenerating hepatocytes.
The role of chrysin and the Ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice
Authors: Bonzo Jessica A. , Bélanger Alain , Tukey Robert H.
Published: January 2007

The flavonoid chrysin is an important dietary substance and induces UGT1A1 protein expression in cell culture. As a representative of the class of dietary flavonoids, clinical investigations have been considered as a means of inducing hepatic UGT1A1 expression. We demonstrate the necessity of a xenobiotic response element (XRE) in support of chrysin induction of UGT1A1 in the human hepatoma cell line HepG2. Receptor binding assays confirm that chrysin is a ligand for the Ah receptor by competition with [3H]2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). However, key differences in Ah receptor recognition and activation ofUGT1A1by chrysin exist when compared with classical mechanisms ofUGT1A1induction by TCDD. Ah receptor degradation, an indicator of Ah receptor activation, does not occur after chrysin treatment, and chrysin cannot transactivate the Ah receptor in a TCDD-dependent fashion. Knock-down of the Ah receptor by siRNA indicates that chrysin uses the Ah receptor in conjunction with other factors through MAP kinase signaling pathways to maximally induceUGT1A1. Most importantly, oral treatment of chrysin to transgenic mice that express the humanUGT1locus is unable to induce UGT1A1 expression in either the small intestine or liver.

Conclusion:

Although the implications for chrysin as an atypical agonist of the Ah receptor are intriguing at the molecular level, the relevance of chrysin-induced transcription for the purpose of clinical therapies or to regulate phase 2–dependent glucuronidation is questionable given the lack ofin vivoregulation of humanUGT1A1by chrysin in a transgenic animal model.
Activation of vascular adhesion protein-1 on liver endothelium results in an NF-κB–dependent increase in lymphocyte adhesion
Authors: Lalor Patricia F. , Sun Phoebe Jun , Weston Chris J. , Martin-Santos Azucena , Wakelam Michael J. O. , Adams David H.
Published: January 2007

Vascular adhesion protein-1 (VAP-1) is an adhesion molecule and amine oxidase that is expressed at high levels in the human liver. It promotes leukocyte adhesion to the liverin vivoand drives lymphocyte transmigration across hepatic sinusoidal endothelial cellsin vitro. We report that in addition to supporting leukocyte adhesion, provision of specific substrate to VAP-1 results in hepatic endothelial cell activation, which can be abrogated by treatment with the enzyme inhibitor semicarbazide. VAP-1–mediated activation was rapid; dependent upon nuclear factor-κB, phosphatidylinositol-3 kinase, and mitogen-activated protein kinase pathways; and led to upregulation of the adhesion molecules E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 and secretion of the chemokine CXCL8. This response resulted in enhanced lymphocyte adhesion, was restricted to hepatic endothelial cells that expressed VAP-1, and was not observed in human umbilical vein endothelial cells.

Conclusion :

We propose that as well as directly promoting adhesion via interactions with the as yet unknown ligand, binding of enzyme substrate to VAP-1 can indirectly promote inflammatory cell recruitment via upregulation of adhesion molecules and chemokines. This response is likely to be important for the recruitment of leukocytes to the liver and suggests that VAP-1 inhibitors have therapeutic potential for treating chronic inflammatory liver disease.
Nonalcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity
Authors: Donthamsetty Shashikiran , Bhave Vishakha S. , Mitra Mayurranjan S. , Latendresse John R. , Mehendale Harihara M.
Published: January 2007

This study tested whether hepatic steatosis sensitizes liver to toxicant-induced injury and investigated the potential mechanisms of hepatotoxic sensitivity. Male Sprague-Dawley rats were fed a methionine- and choline-deficient diet for 31 days to induce steatosis. On the 32nd day, administration of a nonlethal dose of CCl4 (2 mL/kg, intraperitoneally) yielded 70% mortality in steatotic rats 12-72 hours after CCl4administration, whereas all nonsteatotic rats survived. Neither CYP2E1 levels nor covalent binding of [14C]CCl4-derived radiolabel differed between the groups, suggesting that increased bioactivation is not the mechanism for this amplified toxicity. Cell division and tissue repair, assessed by [3H]thymidine incorporation and proliferative cell nuclear antigen assay, were inhibited in the steatotic livers after CCl4administration and led to progressive expansion of liver injury culminating in mortality. The hypothesis that fatty hepatocytes undergo cell cycle arrest due to (1) an inability to replenish ATP due to overexpressed uncoupling protein-2 (UCP-2) or (2) induction of growth inhibitor p21 leading to G1/S phase arrest was tested. Steatotic livers showed 10-fold lower ATP levels due to upregulated UCP-2 throughout the time course after CCl4 administration, leading to sustained inhibition of cell division. Western blot analysis revealed an up-regulation of p21 due to overexpression of TGF β1 and p53 and down-regulation of transcription factor Foxm1b in steatotic livers leading to lower phosphorylated retinoblastoma protein. Thus, fatty hepatocytes fail to undergo compensatory cell division, rendering the liver susceptible to progression of liver injury.

Conclusion :

Impaired tissue repair sensitizes the steatotic livers to hepatotoxicity.
Adding-on versus switching-to adefovir therapy in lamivudine-resistant HBeAg-negative chronic hepatitis B
Authors: Rapti Irene , Dimou Evangelini , Mitsoula Panayota , Hadziyannis Stephanos J.
Published: January 2007

We studied the long-term efficacy of adefovir dipivoxil (ADV) treatment in 42 HBeAg-negative patients with chronic hepatitis B (CHB) who had developed genotypical lamivudine (LAM) resistance with virological and clinical breakthroughs under long-term LAM treatment. Patients were allocated in 2 treatment groups. In the first (n = 14), LAM was switched to ADV monotherapy whereas in the second (n = 28) ADV was added to LAM. The two groups did not differ in patients' characteristics, all of them having HBV genotype D infection with the precore stop codon mutation. Within 12 months from start of ADV treatment, serum HBV DNA became nondetectable and ALT normalized in 71% and 90% of patients, respectively, with no difference between the 2 arms. Patients with baseline HBV DNA levels less than 107 copies/ml experienced a significantly earlier and more frequent decline in serum HBV DNA to nondetectable levels as compared with patients with greater than 107 HBV DNA copies/ml at baseline (

P

= 0.0013) This response has hitherto been maintained (median treatment duration 40 months) in all patients with ADV added to LAM, whereas virological and biochemical breakthroughs due to development of ADV signature resistance mutations occurred in 3 of 14 patients (21%) on ADV monotherapy 15 to 18 months from start of treatment (

P

= 0.0174).

Conclusion:

Adding ADV to LAM in HBeAg-negative CHB patients with LAM resistance effectively suppresses HBV replication in most of them and induces biochemical remission that can be maintained in all of them at least for 3 years without any evidence of development of resistance to ADV.
Opposing roles of gp130-mediated STAT-3 and ERK-1/2 signaling in liver progenitor cell migration and proliferation
Authors: Yeoh George C. T. , Ernst Matthias , Rose-John Stefan , Akhurst Barbara , Payne Christine , Long Sarah , Alexander Warren , Croker Ben , Grail Dianne , Matthews Vance B.
Published: January 2007

Gp130-mediated IL-6 signaling may play a role in oval cell proliferation

in vivo

. Levels of IL-6 are elevated in livers of mice treated with a choline-deficient ethionine-supplemented (CDE) diet that induces oval cells, and there is a reduction of oval cells in IL-6 knockout mice. The CDE diet recapitulates characteristics of chronic liver injury in humans. In this study, we determined the impact of IL-6 signaling on oval cell-mediated liver regeneration

in vivo

. Signaling pathways downstream of gp130 activation were also dissected. Numbers of A6+ve liver progenitor oval cells (LPCs) in CDE-treated murine liver were detected by immunohistochemistry and quantified. Levels of oval cell migration and proliferation were compared in CDE-treated mouse strains that depict models of gp130-mediated hyperactive ERK-1/2 signaling (gp130ΔSTAT), hyperactive STAT-3 signaling (gp130Y757F and Socs-3−/ΔAlb) or active ERK-1/2 as well as active STAT-3 signaling (wild-type). The A6+ve LPC numbers were increased with IL-6 treatment

in vivo

. The gp130Y757F mice displayed increased A6+ve LPCs numbers compared with wild-type and gp130ΔSTAT mice. Numbers of A6+ve LPCs were also increased in the livers of CDE treated Socs-3−/ΔAlbmice compared with their control counterparts. Lastly, inhibition of ERK-1/2 activation in cultured oval cells increased hyper IL-6-induced cell growth. For the first time, we have dissected the gp130-mediated signaling pathways, which influence liver progenitor oval cell proliferation.

Conclusion :

Hyperactive STAT-3 signaling results in enhanced oval cell numbers, whereas ERK-1/2 activation suppresses oval cell proliferation.
Two New Sesquiterpenes from Ligularia lankongensis
Authors: Tan Ai‐Min , He Hong‐Ping , Zhang Mian , Wang Zheng‐Tao , Hao Xiao‐Jiang
Published: January 2007

In continuation of a systematic investigation into the chemotaxonomic and bioactive components of pyrrolizidine alkaloids and sesquiterpenoids of Ligularia plants, two new, highly oxygenated, rare bisabolene sesquiterpenes, compounds 1 and 2, were isolated from the roots of Ligularia lankongensis. Their structures and relative configurations were elucidated by means of 1D‐ and 2D‐NMR as well as MS analyses.
Zirconyl Chloride (= Dichlorooxozirconium) as an Efficient Catalyst for One‐Pot Multicomponent Synthesis of Homoallylic Amines
Authors: Das Biswanath , Ravikanth Bommena , Reddy Kongara Ravinder , Rao Bommena Vittal
Published: January 2007

Zirconyl chloride (ZrOCl2) catalyzes efficiently the one‐pot three component reactions of aldehydes, amines, and allyltributylstannane at room temperature to furnish the corresponding homoallylic amines in short reaction times and in excellent yields.
Efficient Regio‐ and Stereoselective Conversions of Oxiranes and Aziridines into β‐(Nitrooxy)‐Substituted Alcohols and Amines by Using Bismuth Nitrate
Authors: Das Biswanath , Krishnaiah Maddeboina , Venkateswarlu Katta , Reddy Vtukuri Saidi
Published: January 2007

Oxiranes and aziridines efficiently undergo ring opening with bismuth nitrate at room temperature to furnish the corresponding β‐(nitrooxy)‐substituted alcohols and amines respectively. The conversions are highly regio‐ and stereoselective and afford the nitrooxy‐compounds in excellent yields within a short period of time.
Stereoselective Aldol Reactions Catalyzed by Acyclic Amino Acids in Aqueous Micelles
Authors: Deng Dong‐Sheng , Cai Jiwen
Published: January 2007

The catalytic properties of all proteinogenic, acyclic amino acids for direct aldol reaction in H2O, assisted by various surfactants, were investigated. The basic and neutral amino acids were shown to be efficient catalysts, giving rise to good‐to‐excellent yields of adducts (up to 95%), with moderate‐to‐good diastereoselectivities (up to 86%), L‐arginine being the most‐effective catalyst. The syn/anti diastereoisomer ratio could be readily tuned by proper choice of the amino acid used. Also, the range of substrates that underwent the reaction was extended to less‐reactive aldehydes carrying electron‐donating Br substituents.
Triterpenoids from the Leaves of Ilex hainanensis
Authors: Zhou Si‐Xiang , Yang Jun‐Shan , Liu Fu‐Cheng , Tu Peng‐Fei
Published: January 2007

Phytochemical investigation on the leaves of Ilex hainanensis Merr. led to the isolation of four new ursane‐ and oleanane‐based triterpenoids, ilexhainanins A–D (1–4), as well as two known compounds, 2α,3β,19α‐trihydroxyurs‐12‐ene‐23,28‐dioic acid and 2α,3β,19α‐trihydroxyolean‐12‐ene‐23,28‐dioic acid. Their structures were elucidated on the basis of chemical and spectroscopic evidence, and by comparison with literature data.