bluuebunny/crossref_metadata_2025 huggingface dataset:
MESIN LASER PERANCANGAN SISTEM KENDALI MESIN LASER ENGRAVING DENGAN ARDUINO NANO
Authors: Irlanto Wisnu Suryo , Marwanto Stephanus , Suharjanto
Published: November 2022

Laser Engraving adalah proses penyinaran bahan baku dengan sinar laser yang membakar permukaan material, sehingga karakter dapat terlihat pada permukaan material. Dalam penelitian ini dibuat sistem kendali pada mesin laser engraving dengan menggunakan mikrokontroler Arduino Nano untuk UMKM builder vape. Sistem mesin ini dikendalikan dengan menggunakan mikrokontroler Arduino Nano yang akan menerima sandi-G dari Aplikasi Engraver Master. sandi-G diterima lewat port serial dari penerjemah sandi-G yang akan menggerakkan motor stepper dan mengaktifkan modul laser. Mesin laser engraving memanfaatkan motor stepper sebagai penggerak lurus pada setiap sumbu X dan Y. Untuk merubah putaran menjadi gerak lurus digunakan motor stepper yang dikombinasikan dengan pulley dan vanbelt. Untuk mengukir (engraving) di permukaan material non metal digunakan modul ultraviolet laser diode yang memiliki daya bakar cukup tinggi. Pada pengujian dengan media kayu tripleks dan beberapa variasi kelajuan pergerakan sinar laser dapat diperoleh gambar yang jelas dan tidak terputus pada kecepatan gerak 500 mm/menit.
PERENCANAAN RANGKAIAN PENGEREMAN DINAMIK PADA MOTOR ARUS BOLAK BALIK INDUKSI 3 PHASE 1 ARAH PUTARAN DENGAN MENGGUNAKAN TIME DELAY RELAY
Authors: Binoto Maju , Hidayatullah Afif
Published: November 2022

Motor induksi 3 phasa disebut juga motor asinkron atau disebut juga mesin tak seremapak. Motor induksi digunakan untuk merubah energi listrik menjadi energi gerak atau putar, motor induksi 3 phasa banyak dipakai pada industri keci sampai dengan industri besar yang dipakai sebagai pengerak untuk produksi di industri-industri. Untuk mendapatkan efisensi yang bagus maka diperlukan cara pemakaain dan pengendalian motor sangat penting sekali. Masih banyak industri kecil dan industri menengah untuk menjalankan dan mematikan motor tanpa pengereman. pada saat tombol start ditekan maka kontaktor 1 aktif dan kontaktor 2 aktif sehingga motor berputar, Saat kontaktor 2 aktif diikuti timer membaca waktu selama 6 detik. Setelah timer selesai membaca waktu kontaktor 1 tetap aktif sedangkan kontaktor 2 off dan motor tidak langsung mati  tetapi pada rotornya masih berputar sampai menunggu waktu selama 28 detik agar motor benar-benar mati. Hal ini dikarenakan pada motor tidak dihasilkan kopel untuk menghentikan motor. Dengan menggunakan Sistem pengereman secara otomatis dengan TDR. Dalam penelitian ini menggunakan 3 buah kontaktor yaitu kontaktor 1 sebagai stand by, kontaktor 2 digunakan untuk menggerakan motor induksi sedangkan kontor 3 digunakan sebagai pengereman motor. Pada saat tombol start ditekan maka kontaktor 1 aktif, kontarktor 2 aktif dan motor berputar, sedangkan kontaktor 3 tidak aktif. Saat kontaktor 2 aktif maka motor berputar dan diikuti timer bekerja membaca waktu selama 6 detik. Setelah selesai timer membaca waktu sebesar 6 detik maka kontaktor 1 aktif, kontaktor 2 mati dan kontaktor 3 aktif dan mematikan motor dengan waktu 0,85 detik. Hal ini disebabkan dengan menggunakan pengereman diode bridge maka timbul suatu kopel rem. Dan kopel rem ini akan bekerja untuk menghentikan energi kinetis yang dihasilkan pada motor. Dengan memakai pengereman ada pengiritan waktu sebesar yaitu 28 detik – 0,85 detik = 27,15 detik. Sedangkan penggunaan TDR untuk mengantikan kerja secara manual yaitu menekan tombol OFF dengan cara otomatis tanpa menekan tombol OFF. Pertama kali TDR disetting waktu selama 6 detik dimana motor akan kontaktor 2 mati sedangkan kontaktor 3 aktif tanpa harus menekan saklar OFF. Pada penelitian ini untuk mematikan motor maka memamfaatkan arus searah dari diode bridge.
ROLE OF ECONOMIC DISPARITY IN FEMALE VICTIMIZATION IN NAGUIB MAHFOUZ’S NOVEL ‘THE BEGINNING AND THE END’
Authors:   Government Graduate College, Block 17, D.G.Khan Pakistan, Hussain Tanveer , . Mehreen ,   Department of English, Ghazi University, D.G.Khan Pakistan, Khan Fatima ,   Ghazi University, D.G.Khan Pakistan
Published: November 2022

The objective of the study is to examine the impact of economic disparity in female victimization in Nagiub Mahfouz’s novel “The Beginning and the End”. Economic inequality has played a key role in maintaining the secondary role given to women. A female is affected in many ways by socio-economic and socio-political structures depending on their class, race, nationality, religion, language, disability, sexual preferences and education (Liu, 2022). The theoretical framework of Socialist Feminism (Armstrong, 2020) was used to understand the concept of inferiority of women in society; the female has been given a secondary position in society on the basis of economic factors throughout the ages. The textual analysis of Naguib Mahfouz’s novel ‘The Beginning and the End’ unfolded the role of economic disparity for female victimization particularly in Egyptian culture. The current study helped not only to explore the reasons of economic disparity in gender roles but also provided a door for further study in same context. Key Words: Economic Disparity, Female victimization, Gender roles, socio-political structures, Egyptian culture and Textual analysis.
IMPACT OF REALITY TV SHOWS ON UNIVERSITY STUDENT’S PERFORMANCE
Authors:   Special Education Department, University of Management and Technology Lahore Pakistan, Faiz Zikra , Azeem Asmaa ,   Special Education Department, University of Management & Technology, Lahore Pakistan, Thakur Ibtasam ,   Lahore College for Women University, Lahore Pakistan
Published: November 2022

Reality TV shows are often featured; these are considered as a type of television programs which do not featured by professional actors. The purpose of the present study was to figure out the impact of reality television shows on the young adult students at university-level. The objectives of the present study were to find out the impact of reality TV shows on university students and to find out the pros and cons of a reality TV show for university students. The quantitative approach was adopted, whereas the research design was descriptive to determine the impact of reality TV shows on university students' performance. The researcher collected data through a cross-sectional survey method technique. Total 800 (400 males and 400 females) students were selected using a random sampling technique of probability sampling. The researchers developed a questionnaire which was consisted of two parts; the first part was consisted of demographical information, whereas the second part comprised of 40 closed-ended items, which were consisted of four subscales; influence of reality TV shows, pros and cons of reality TV shows, reality TV shows and impact on learning and education, and role of the show in an Education). The data were analyzed through descriptive and inferential statistical techniques using SPSS version 21. Results of the study showed that reality TV shows negatively impact students' minds. The majority of the participants agreed that they use the WhatsApp compared to other social media Apps. Reality TV shows engage students most of the time, and they never complete their tasks on time. Students are negatively affected by reality shows in more than one ways. Students sometimes associate reality shows with the real world because these shows focus on bullying, violent conduct, and unhealthy competitiveness. It is recommended that government must take steps to prevent the negative impact of reality TV shows on students. Keywords: Reality TV shows, University Students, Pros and Cons.
ROLE OF NEW MEDIA IN PROMOTION OF TOURISM: AN ANALYSIS OF FAISALABAD’S YOUTH PERCEPTION
Authors:   School of Media & Communication, University of Management & Technology, Lahore Pakistan, Khalid Aemen , Toor Shazia Ismail ,   School of Communication Studies, University of the Punjab, Lahore Pakistan, Karamat Kiran ,   Department of Media Studies, Kinnaird College for Women, Lahore Pakistan
Published: November 2022

The present research study is to explore and investigate the role of new media in the promotion of tourism: an analysis of Faisalabad’s youth perception. This study investigates infrastructures and management problems for tourists, facilities, new destinations, accommodations, and curriculum issues of tourism in Pakistan. A quantitative research approach was applied. Convenience sampling, a form of non-probability sampling was employed in this study. The survey was conducted for this research. The questionnaire was designed mainly using closed-ended questions. 400 tourists were the sample size of this study from Faisalabad. Results highlight that new media is significant in the promotion of tourism. Communication channels promoted this study to conclude that new media is considered one of the best tools for the promotion of tourism because of the efficiency available in using social media as compared to mass media. New media is used for awareness and information search engines to the trips, updating friends about departure timings, arrival timings, destinations, places, locations, and weather during the trip, and sharing the trip experience regarding the trip activity. The study provides awareness about national and international trends in traveling behavior or attitude in Pakistan. Keywords: New Media, Tourism, Consumer satisfaction, destination
Análise da eficiência do Ultrassom Point of Care no diagnóstico de doenças biliares
Authors: Lessa Matheus Henrique de Medeiros , Carvalho Sílvio Francisco de Almeida , De Souza Milena Rafaela Pinto Moraes , Gama Pedro Figueiredo
Published: November 2022

Introdução: A litíase biliar é um dos principais motivos de hospitalização por enfermidade gastrintestinal, porém, há outras patologias que afetam o canal biliar, como a colecistite. Nesse sentido, a ultrassonografia é o primeiro exame solicitado, uma vez que concede informações de qualidade, sem uso da radiação ionizante, sendo encontrada facilmente, além de ser um procedimento não invasivo. Neste ponto, pôde-se incluir o método USG “point of care”, o qual tem se demonstrado cada vez mais essencial para diagnósticos à beira do leito, a fim de diminuir o tempo entre diagnóstico e conduta necessária, aumentando o bom prognóstico das patologias. Objetivo: Definir, através de uma revisão integrativa, o valor diagnóstico da ultrassonografia “point of care”, mediante análise de sua acurácia em quadros patológicos das vias biliares. Metodologia: Foram encontrados 23 artigos científicos na base de dados PubMed, produzidos nos últimos 5 anos, entre 2017 e 2022, no idioma inglês, sendo selecionados 3 artigos, mediante os critérios de inclusão e exclusão. Foram utilizados os descritores: “Point-of-care ultrasound”, “gallstone disease” e “bedside ultrasonography”. Resultados e Discussão: Os estudos selecionados buscaram determinar a acurácia, e sensibilidade da ultrassonografia “point of care”, quanto ao diagnóstico de doenças das vias biliares, por meio de comparações entre a interpretação da imagem obtida por um médico emergencista atuante no pronto-socorro, com o USG “point of care”, e a interpretação de um radiologista, através de um ultrassom mais aperfeiçoado, e uma tomografia computadorizada. Diante disso, verificou-se uma grande taxa de correlação entre ambas interpretações, sendo essa taxa maior, quanto à presença de cálculos biliares. Conclusão: Observou-se que o USG “point of care” é uma ferramenta viável e importante no diagnóstico da colelitíase e da colecistite, possibilitando maior agilidade no diagnóstico e no atendimento, bem como na tomada de decisão cirúrgica, reduzindo, consequentemente os custos e morbidade do tratamento.
Mucosectomia esofágica: uma alternativa no tratamento do megaesôfago avançado. Um relato de caso
Authors: Souza Nathália Lima , De Sousa Piter Picole Silva , Pulgatti Mariana Bobato , Da Cruz e Silva Yara Rocha , De Rezende Achiles Queiroz Monteiro
Published: November 2022

Introdução: O megaesôfago consiste na dilatação da luz esofágica secundária a progressiva lesão do plexo intramural do esôfago, levando a um déficit no relaxamento ou não relaxamento do esfíncter esofágico inferior (EEI), a Acalasia, com aparecimento de contrações não peristálticas (ondas terciárias), ondas peristálticas com menor amplitude, até aperistalse do corpo esofageano, sendo atualmente a maioria dos casos de origem idiopática. Segundo classificação de Mascarenhas, que varia de I a IV conforme o seu diâmetro transverso observado na radiografia baritada do esôfago. Em estágios iniciais, a cardiomiotomia é preconizada, no megaesôfago avançado (grau IV) prioriza-se a esofagectomia, entretanto, quando o paciente não apresenta um PS (Performance-status) adequado, pode-se empregar cirurgia de Serra-Dória ou Thal Hatafuku. Objetivo: Apresentar caso de um paciente com megaesôfago Grau IV submetido à mucosectomia esofágica no serviço público de Rondônia, como alternativa viável a esofagectomia. Relato de caso: Paciente masculino, 58 anos, diagnosticado com megaesôfago de origem idiopática, Mascarenhas IV pelo REED. Realizou endoscopia com cromoscopia, sem evidências para displasia. Bom PS, sem comorbidades. Procedimento realizado através de laparotomia xifo-umbilical e cervicotomia lateral esquerda. Com mucosa íntegra após dissecção, possibilitando a transposição do tubo gástrico recém confeccionado até a região cervical, através da túnica muscular do esôfago. Recebeu alta após 3 semanas de internação por fístula da anastomose esôfago-gástrica, com tratamento conservador.  Discussão: O tratamento ideal do megesôfago avançado (Grau IV) consiste na esofagectomia, porém, esta cirurgia apresenta alta morbidade cirúrgica com manipulação do mediastino posterior promovendo maiores complicações quando comparados à mucosectomia, principalmente, complicações pleuropulmonares como demonstrado por Oliveira et al. (2008), onde houve o dobro de complicações pós-operatórias (65% vs 35%, p < 0,05), além do maior tempo cirúrgico e de hospitalização. Conclusão: Considera-se a mucosectomia como alternativa plausível, com técnica reprodutível, segura e de menor tempo cirúrgico para tratar megaesôfago de origem idiopática.
QSAR of Acyl pinostrobin derivatives as Anti-breast cancer against HER-2 receptor and their ADMET properties based on in silico Study
Authors: Lina Agustin Salsa , Widiandani Tri , Hardjono Suko , Tri Purwanto Bambang
Published: November 2022

Pinostrobin is a compound with potential anti-breast cancer activity, but its activity is lower than the drugs used clinically. Modifying pinostrobin to form 9 acyl pinostrobin derivatives (AP1-AP9) is a method that changes physicochemical properties to affect the activity and ADMET properties. This study aims to predict the anti-breast cancer activity of pinostrobin and acyl pinostrobin derivatives against HER-2 receptor by molecular docking, obtain the most influential descriptor by QSAR study, and predict ADMET properties of these compounds. The molecular docking was using MVD on the HER-2 receptor (5JEB.pdb). The parameters observed were the Rerank Score (RS) and the amino acid residues. The physicochemical properties (logP, total energy, and molecular weight) for the QSAR study were determined using Chem Draw and Chem 3D. The QSAR study was carried out using SPSS. Prediction of ADMET properties was determined using the pkCSM. The molecular docking result showed that all acyl pinostrobin derivatives have a lower RS than pinostrobin. The lowest RS was indicated by pinostrobin nonanoate (AP8) with a value = -108,156 kcal/mol. The influential parameters in the QSAR study were the logP and MW. The results of this study also showed that the ADME properties of acyl pinostrobin derivatives were mainly better than pinostrobin, and all derivatives were also less toxic than pinostrobin. These results indicate that acyl pinostrobin derivatives, especially pinostrobin nonanoate (AP8), can be further synthesized as anti-breast cancer by considering the QSAR study's best equation.
Formulation and Characterization of Phythosomal Topical Gel of Ocimum Basilicum
Authors: P. Raj Megha , Reichal C. Rubina , S. Manju , M. Shobana , M. Sangeetha
Published: November 2022

The core objective of the present study was to formulate and characterize Ocimum Basilicum topical phytosomal gel. Ocimum basilicum is an important traditional medicinal plant. Some investigations reported that it showed the antimicrobial and wound healing activity. Phytosomes are vesicular drug delivery system which has proved to be beneficial in providing good absorption and better bioavailability over the herbal conventional extracts. The phytosomes were formulated using Ocimum basilicum extract. The formulated phytosomes were characterized using various methods like entrapment efficiency, percentage yield, stability studies, drug content, in-vitro drug diffusion studies, anti-microbial activity and SEM. The topical phytosomal gel of ocimum basilicum was prepared. The formulated gel was evaluated pH, Spreadability, Extrudability, Drug content, in-vitro drug diffusion study and drug release kinetics. The stability studies were carried out as per ICH guidelines. The prepared phytosomal gel was safe, convenient, efficient and also showed better penetration into the skin. Thus, it can be concluded that the topical phytosomal gel may serve as promising dosage form in the treatment of microbial effect.
Design of Amide bioisosteres of Flutamide as Novel Androgen Receptor Antagonist in Prostate Cancer Therapy
Authors: K. Gupta Ajay , K. Jain Sanmati
Published: November 2022

Prostate cancer is the second leading cause of cancer death in men. Androgen receptor (AR) inhibitor is one of class of drug used in this disease. AR inhibitors include bicalutamide, flutamide, nilutamide, apalutamide, darolutamide and enzalutamide. Among them Flutamide is being selected because it causes liver damage on long term use that can be serious or life-threatening. In the current study, Bioisosteric approach has been used for amide group in the Flutamide molecule in order to develop the newer analogues having lesser side effects like liver damage, which is major cause of the drug withdrawal. Therefore amide bioisosteres of it are designed using bioisosteric approach in order to develop relatively safe compounds. A wide variety of amide bioisosteres of Flutamide were generated i.e., Ester, Amide, Reverse amide, Urea, Carbamate, Reverse Ester, Thioamide, 1,2,4-oxadiazole, Sulphonamide, Ketone etc., using MolOpt. Pharmacokinetic and toxicity (ADMET) properties of newly designed analogues are computed by using ADMElab2.0 and pkCSM. Druglikeness and Drugscore was calculated by PEO. All the ligands obey the Lipinski rule and had good human intestinal absorption. Flutamide is used as the reference drug. The results indicate that compound 002 and 022 showed NR-AR binding (desirable in Prostate cancer) and QED value (measure of drug likeness; > 0.67) comparable with the standard drug. These compounds showed low toxicity [human hepatotoxicity (H-HT) and drug induced liver injury (DILI)] as compared to Flutamide. This study could lead to the further development of potent AR antagonist for the treatment of prostate cancer.
Natural Gums and Mucilage as Gelling agents in Topical Gel Formulation
Authors: Kumari J Krishna , Hemanth Kumar Bandaru , D Prasanthi
Published: November 2022

The study was conducted to study the gelling efficiency of natural gums (tamarind seed gum) and mucilage (moringa mucilage) using ibuprofen as model drug. Topical drug delivery (TDS) eliminates first pass metabolism and improves bioavailability. Hydrogels are dispersions of network of polymer chains in water as colloidal gels. Ibuprofen an anti-inflammatory, was chosen as a model drug in the preparation of hydrogel for site targeted action and to avoid side effects. Physical properties like swelling index, solubility, loss on drying, flow properties were evaluated. Chemical characterization of isolated gum and mucilage revealed presence of polysaccharides. Ibuprofen topical gels with natural gum (tamarind seed gum (1-7%), moringa mucilage (2-8%) were compared with official xanthan gum (1-4%), guar gum (1-3%) as natural gelling agents and HPMC K4M (1-6%), HPMC K100M (1-6%) and sodium alginate (2-6%) as semi synthetic gelling agents. Drug and excipients are compatible with each other by FTIR studies. The prepared gel formulations were evaluated for clarity, homogeneity, spreadability, drug content, in-vitro diffusion, ex-vivo permeation, skin irritation and stability studies. All formulations have shown better physicochemical properties. Based on the maximum percentage of drug release, formulations containing natural polymers tamarind seed gum (5%), moringa mucilage (8%), xanthan gum (4%), guar gum (3%) were optimized. And semi synthetic polymers HPMC K4M (4%), HPMC K100M (3%), sodium alginate (6%) were optimized. NF10 formulation with guar gum (3%) is optimized based on the percentage of drug release (27.0±0.14%) for 8 hrs, flux of (427.2±0.09µg/cm2/hr), cumulative amount of drug permeated Q8 (329±1.53µg/cm²) and permeability coefficient of (17.08±1.04 ×10-3cm/hr) when compared with tamarind gum (5%), NF1 (23.8±0.13%), (290±1.04µg/cm²), (376.6±0.04µg/cm2/hr), (15.04±0.03×10-3cm/hr) and moringa mucilage (8%), NF3 (14.3±0.19%), (175±0.90µg/cm²), (227.1±0.03µg/cm2/hr), (9.08±0.02×10-3cm/hr). The drug release pattern was found to follow first order kinetics and korsemeyer peppas release mechanism with fickian diffusion release. Formulations were found to be non-irritant and stable. Tamarind gum and moringa mucilage were efficient as gelling agent in preparation of ibuprofen topical gel but showed retarding effect when compared with official guar gum.
Correlation between Interleukin-6, CRP, and LDH in COVID-19 patients of Dr. Soetomo Teaching Hospital, Surabaya, Indonesia
Authors: Oetama Adiatmaja Christophorus , Nugraha Jusak , Utariani Arie
Published: November 2022

This cross-sectional study was conducted from June 2020 to May 2021. This study recruited 86 patients with confirmed PCR positive for COVID-19 who were treated in the isolation ward of Dr. Soetomo Teaching Hospital, Surabaya, Indonesia. Examination of serum levels of IL-6, CRP, and LDH was performed on the first and the sixth day of hospital admission. Found on the first day of admission the same significant correlation between IL-6 and CRP on males and females with rs=0,475 (p<0,01) and rs=0,663 (p<0,01) respectively. Correlation between IL-6 and LDH on the first day of admission on both males and females were also significant with rs=0,403 (p<0,01) and rs=0,484 (p<0,01) respectively. IL-6 and CRP on the sixth day of admission showed significant correlation on males with rs=0,621 (p<0,01), but not on females with rs=0,120 (p=0,586). IL-6 and LDH on the sixth day of admission also showed significant correlation on males with rs=0,544 (p<0,01), but not on females with rs=0,030 (p=0,893). In conclusion, there were significant positive correlations between IL-6, CRP, and LDH on the first day of admission on both male and female subjects which showed that IL-6 was associated with inflammatory response on the acute phase of COVID-19. However, on the sixth day of admission, IL-6 showed significant positive correlations with CRP and LDH only on male subjects, but not on female subjects.
Effect of Andrographolide and Resveratrol on OX1R and Prepro-orexin mRNA expression in CIPN-induced hypothalamus of mice with oxaliplatin
Authors: Ardianto Chrismawan , Lestari Judoko Ardian , Aprilia Mirza , Nusantara Ratri Dinda Monika , Ariyani Toetik , Rahmadi Mahardian , Khotib Junaidi
Published: November 2022

Chemotherapy-induced peripheral neuropathy (CIPN) is a one of side effect in cancer patients that receive antineoplastic agent, like oxaliplatin. Orexinergic system in the hypothalamus is the one of system that modulate nociceptive and neuropathy. Because there is flavonoids such as resveratrol and andrographolide that may prevent chemotherapy induced peripheral neuropathy, this study analyzed effects of andrographolide and resveratrol treatment on PPOrx and OX1R mRNA expression in hypothalamic oxaliplatin-induced mice. Materials and Methods This study was conducted for 22 days in mice. Mice injected with oxaliplatin followed by andrographolide or resveratrol. Chemotherapy induced peripheral neuropathic pain was assessed based on withdrawal threshold, mRNA PPOrx expression, and mRNA OX1R expression. Results The results showed that intraperitoneal injection of 100mg/kg resveratrol and 20mg/kg andrographolide increased the withdrawal threshold after oxaliplatin induction. Resveratrol administration also increased the relative expression of PPOrx mRNA significantly, but not the OX1R mRNA relative expression. On the other hand, administration of andrographolide did not cause a change in the expression of PPOrx and OX1R in the hypothalamus. Conclusions Intraperitoneal injection of andrographolide and resveratrol reduces the mechanical allodynia response in oxaliplatin-induced mice significantly. The mechanism of andrographolide increases the withdrawal threshold does not via the orexinergic system, but the mechanism of resveratrol via the orexinergic system.
A retrospective clinicopathological study of inherited bleeding disorders in a tertiary care centre of Uttar Pradesh
Authors: Rani Deepa , Pandey Pawan , Singh Anu , Kumar Sandip
Published: November 2022

BACKGROUND: Inherited Bleeding Disorders (IBD) include various disease that reflect abnormalities of primary and secondary hemostasis. The pathophysiology of these disorders can be explained on the basis of vessel wall abnormalities, platelet disorders and coagulation factor defects. To further elaborate and enhance our understanding on these disorders, a 6-year retrospective study (2014-2020) was conducted on the patients referred to the coagulation section of the Hematology Department (Department of Pathology, IMS BHU). These included the ones who had suffered from bleeding tendencies at one or more sites with other relevant clinical history. AIM: - This study was aimed to assess the prevalence, clinical spectrum, and haematological profile of inherited bleeding disorder among patients of Eastern UP and Bihar. It also focussed on various epidemiological factors including age, sex, family inheritance and consanguinity. MATERIALS AND METHODS: Three hundred and two patients matched our criteria. The age of these patients ranged from neonate to 50. A detailed relevant clinical history was taken for all the patients. These categories of patients were screened with routine tests like platelet count, Prothrombin Time (PT), Active Partial Thromboplastin Time (APTT), Breathing Time (BT), Clotting Time (CT) and a Complete Blood Cell Count (CBC). A factor assay was performed if indicated by the results of the screening assays. RESULTS: Out of 302 patients, 280patients (92.70%) were diagnosed with factor VIII deficiency. This category further comprised of 63.57% Hemophilia A cases (n=192), and 12.58%hemophilia B cases (n=38). Another cluster of 16.55% were diagnosed as Von Willebrand Disease (n=50). Also, a subset of the total patient population (7.30%) was diagnosed with an entity called Rare Inherited Coagulation Deficiency (RICD) which was further designated on the basis of specific factor assays. Most common clinical feature encountered was hematoma followed by ecchymosis, hemarthrosis, gum bleeding and epistaxis. CONCLUSION: The most common IBD was Hemophilia A in this subcategory of patients. Children under 5 year age were most affected making it the most vulnerable age group amounting to 38.73% of all recorded cases. Male population was more affected forming majority of the patients. Sporadic cases were more common than the inherited ones.
Study on effect of Sorafenib: With Special Reference to Alterations in Histopathological Parameters in Male Swiss Albino Mice
Authors: D Shetty Surekha , Bairy K. Laxminarayana , Rao K.G. Mohandas , Kumar Naveen
Published: November 2022

Background: Drug induced infertility which may be permanent or temporary, is regarded to be a major clinical problem. Sorafenib is a new drug that is being used for advanced renal cell carcinoma and hepatocellular carcinoma. This study aimed to investigate the effect of sorafenib on the histopathology of testes in male mice. Materials and Methods: Thirty animals (9-12 weeks old) were divided into control, positive control and treatment groups. Treatment groups received 25, 50 and 100mg/kg body weight of sorafenib orally for seven consecutive days at intervals of 24 hours between two administrations. Results: Microscopic anatomy of the testes showed sloughing of the germ cells, reduction in the number of sperm cells and variation in the size and shape of the seminiferous tubules. There was no significant change in the diameter of the seminiferous tubules in most of the treated groups except the 5th-week group when compared with control groups. The epithelial height was reduced significantly (P<0.05) in the 4th, 5th and 7th weeks in treated groups compared to that of control groups. Conclusion: The result conforms to the toxic effect of sorafenib in testes of male mice, but this effect is reversible once the drug is withdrawn.
Are there effects of Extract Coffee Robust Lampung as Immunonutrition in Chicken against Salmonellosis?
Authors: Eka R Lilik , Rosyidi Djalal , Qosimah Dahliatul , Amalia A Indah , Prasetyo Dodik , Kaltaria A Agri
Published: November 2022

The poultry industry was an industry that supported the nutritional needs of all individuals and the world's food needs. Coffee was a natural ingredient consisting of antioxidant molecules such as Chlorogenic Acid (CGA). This research using ISA brown chicken layer, which divided into five groups such as healthy chicken (control group (C-)), chicken infected with Salmonella enteritidis 108 CFU/ml (control group (C+)), chicken infected with S. enteritidis 108CFU/ml and extract Coffee consecutive 500, 1000 and 1500 mg/kg body weight (BW) group (T1, T2, and T3). The relative level of TCD4, CD8, and CD45 cells was performed with One way ANOVA test. The research results showed that the relative level of TCD4+, TCD8+ and TCD45+ cells in T1 and T2 groups was not significant with the negative control group. The conclusion is that extracting Coffee in the T1 and T2 groups with a 500-1000mg/kg BW dose could regulate immune cell activation in chicken infected by S. enteritidis bacteria.
APPLICATION OF THE METHODOLOGY FOR EVALUATING THE EFFECTIVENESS OF TECHNICAL MEANS IN THE DESIGN OF NEW SECURITY FRONTIERS
Authors: MIKHNIONAK E. , KHIZNIAK A.
Published: November 2022

The article discusses the procedure for applying the methodology developed by the authors for evaluating the effectiveness of technical means as part of an integrated system of state border protection to substantiate the composition of technical means in the design of new security boundaries.
SIMPLIFIED ALGORITHM FOR GRAPHIC REPRESENTATION
OF THREE-DIMENSIONAL DATA IN RAD DEVELOPMENT
OF WINDOW APPLICATIONS IN THE PASCALABC.NET ENVIRONMENT
Authors: SUPRUNCHYK Y. , KOHAN P. , DAVYDOUSKAYA V.
Published: November 2022

An algorithm for presentation a three-dimensional graphical dependency in the PascalABC.NET environment using the Bitmap class, by means of "contour surfaces" in the RAD development of custom window applications (Windows Form Application) has been developed. A comparative analysis of the graphical interpretation of the calculation results in the computer mathematics systems MATLAB, MathCAD and PascalABC.NET has

been carried out.
OPTICAL AND STRENGTH PROPERTIES OF SACRIFICIAL LAYERS
BASED ON POLYIMIDE FILMS
Authors: VABISHCHEVICH S. , VABISHCHEVICH N. , BRINKEVICH D. , PROSOLOVICH V. , KOLOS V. , ZUBOVA O.
Published: November 2022

Optical and strength properties of films of a polyimide composition (polyimide PI-2610) for creating a sacrificial

layer deposited on the surface of single-crystal silicon plates of the KDB-10 brand by centrifugation are

investigated. It has been established that they behave like elastoplastic materials. The true microhardness of polyimide

PI-2610, measured at a load of 2 g, was ~0,5 GPa. The spectra of the disturbed total internal reflection

(NPVO) of polyimide PI-2610 were compared with the spectra of the NPVO of pyrrole and kapton polyimide.

In the spectrum of the polyimide PI-2610, there are bands of vibrations of the 5-membered ring and valence

vibrations of the C–Nst and CO–Cst groups. The most intense band in the spectrum of NPVO (as in pyrrole) is the band

of deformation vibrations C-H with a maximum at 734 cm-1. The band at ~1700 cm-1, caused by valence vibrations

of the C=O double bond, has two closely spaced maxima at 1706 and 1692 cm-1, which indicates two variants

of the force field around the C=O bond. The presence of hydroxyl O–H groups in the spectra of polyimide

PI-2610 was detected due to the presence of residual water in the polyimide structure.
A gyermekkorban megtapasztalt szülői bánásmód és a családi kapcsolatok hatása az empátiára
Authors: Kovács Dóra , Mészáros Veronika , Smohai Máté , Tanyi Zsuzsanna , Ferenczi Andrea , Szili Ilona , Jakubovits Edit , Kövi Zsuzsanna
Published: November 2022

Cél: A tanulmány célja annak vizsgálata, hogy a gyermekkorban megtapasztalt szülői bánásmód és családi kapcsolatok milyen összefüggésben vannak a felnőttkori empátiával. Módszer: A vizsgálatban 1312 egészséges felnőtt személy vett részt, akik kitöltötték egyrészt az Interperszonális Reaktivitás Index (IRI) skálát és a Simon Baron Cohen által kidolgozott Empátia Kvóciens (EQ) skálát, valamint a Szülői Bánásmód kérdőívet (PBI) és a Családi Kapcsolatok (FRQ) kérdőívet. Eredmények: Nem találtunk szignifikáns összefüggést a gyermekkori szülői hatások és a felnőttkori empátia, illetve alskálái között, sem az általános mintában, sem a nőknél. A férfiaknál azonban gyenge, de szignifikáns összefüggést találtunk a felnőttkori kognitív empátia, azaz a szempontváltás képessége és különféle apai hatások között. Az FRQ apai szabadságadás faktora pozitív kapcsolatban, az FRQ apai bántalmazása és a PBI apai korlátozása negatív kapcsolatban áll a szempontváltás képességével. Az empátiás distressz az FRQ apai dominanciájával és a PBI anyai túlvédéssel mutatott gyenge kapcsolatot. A vizsgálat a felnőtt férfiak saját apjuk utólagos értékelésének fontosságára hívja fel a figyelmet.
Biopesticides from algae and their potential for sustainable agriculture and environmental protection
Authors: Meenakshi B. Bhattacharjee
Published: November 2022

Agricultural crops have become more resistant to synthetic pesticides and pressure mounts regarding their effect on our health and the environment. When these compounds leach into the ground waters, they become direct sources of human health hazards. Also, agricultural runoffs can cause widespread damage to flora fauna and in general affect the food chain in an ecosystem. To combat these deleterious effects, the race is on to bring biopesticides to market that are safe, effective at scale, affordable and can ensure future food security. In this present scenario there is an urgent need to look for alternate sources of similar compounds to replace synthetic pesticides that are sustainable, ecofriendly, and easily available to be mass produced. In this effort microalgae may play a very significant role as they have the capacity to produce a wide array of bioactive compounds with pesticidal properties. As a part of their daily metabolic activities through different physiological pathways they are known to produce and release compounds with anti-bacterial, anti-fungal, anti-protozoal, pesticidal, insecticidal properties. Microalgae, especially the cyanobacteria have very fast growth rates and are potent sources of raw material for the generation of these compounds therefore considered significant while considering biopesticides to replace synthetic ones. This review explores the use of microalgae driven release of biochemicals and secondary metabolites produced by microalgae, or microalgal biomass, that can serve as future promising biopesticides to replace the agrochemicals used these days in agriculture.
Response of Ruellia simplex plants grown under water intervals and anti-transpirant treatments
Authors: Sami Ali Metwally  , Bedour Helmy Abou-Leila  , Nermeen Mahdy Taha  , Sharbat Leithy Mohamed
Published: November 2022

Ruellia is herbaceous perennials are described as colorful groundcovers and it is very popular landscape plant cuttings of Ruellia plant were planted in pots. In the National Research Centre's greenhouse in Dokki, Giza, Egypt. A pot experiment was conducted in July 2020 and 2022 to examine the influence of KCl spraying and duration of irrigation on Ruellia plant growth and chemical contents. The current study compares the growth parameters of plants treated with KCl in three sprays at concentrations (0, 50 and 100 ppm) and water regime (3, 6 and 9 days) to those of control plants. However, increasing irrigation intervals for Ruellia plants there had no significant on growth parameters (plant height, branches number, root length, stem diameter and fresh and dry weight of shoots), while increasing irrigation intervals from 3days up to 9 days, increased flower number and delayed flowering. In addition, it is evident that N% was the highest by increasing irrigation intervals up to 9 days while P% showed a constant content, however the lower N% was recorded with the low irrigation intervals. Carbohydrate % as well as protein and photosynthetic pigments saved the same trend percentage. It can be concluded that, the increasing KCl concentration level up to 100 ppm caused an increase in previous mentioned vegetative growth parameters, flower number, flowering date, and chemical constituents (total chlorophyll, carbohydrate, protein%, carotenoids and mineral elements (N, P and K) concentrations compared with control and other KCl treatments. The purpose of this study is to learn more about the effects of KCl and water intervals on plant development and chemical components.
EcoGothic Anxiety in Ambrose Bierce’s “The Eyes of the Panther” and Lauren Groff’s “The Midnight Zone”
Authors: Chittenden Kelly
Published: November 2022

This paper employs EcoGothic theories and ecofeminist criticism to explore the similarities between Ambrose Bierce’s 1897 story “The Eyes of the Panther” and Lauren Groff’s 2016 story “The Midnight Zone.” Both stories place women in isolated wilderness spaces to probe the boundaries between nature and culture and to condemn human destruction of the nonhuman world. The stories also include Gothic tropes of entrapment and psychological trauma to expose restrictive cultural ideals that constrain women into passive roles. In Bierce’s and Groff’s respective stories, the female characters’ trauma-induced transformation into panther form allows them to challenge the interconnected subjugation of women and the nonhuman world. While each story undermines these destructive ideologies, only “The Midnight Zone” suggests a more positive alternative. The woman in Bierce’s story is killed by a hunter, but the narrator of Groff’s story survives and retains her panther-like qualities. Her survival suggests an ideology based not on the domination of nature and women but on the generative possibilities of challenging boundaries.
Potential utilization of purslane (Portulaca oleracea L.) as food ingredients and traditional medicine
Authors: Marina Silalahi
Published: November 2022

Portulaca oleracea (PO) is a type of wild plant that has long been used as food and traditional medicine. This study aims to examine the use of PO as a food ingredient and traditional medicine and its bioactivity. The research method is a literature study on various online scientific sources from Google scholar using the keywords PO and uses PO. The information obtained is synthesized so that it can explain the use of PO in a comprehensive manner. Purslane is a nutritious vegetable with high antioxidant properties and has been recognized as the richest source of a-linolenic acid, omega-3 fatty acids, ascorbic acid, glutathione, a-tocopherol and b-carotene. Ethnobotanically PO is used for the treatment of various diseases such as skin diseases, fever, dysentery, diarrhea, hemorrhoids, kidney, liver and spleen disease. The bioactivities PO is analgesic, antibacterial, skeletal muscle relaxant, wound healing, anti-inflammatory and radical scavenger, anti-inflammatory, antioxidant, antibacterial, and antitumor. The compounds portulacerebroside B, portulacerebroside C, portulacerebroside D and portulaceramide A showed significant antibacterial effects on enteropathogenic bacteria in vitro. PO has the potential to be developed as a nutraceutical, especially to treat digestive tract disorders.
Valorization of wild fruits for human nutrition in demographic pressure challenges: Perception of fruit traders on plants species under anthropogenic threats
Authors: Audray Vodounou  , Euloge Sènan Adjou  , Fréjuce M Kplaïssa  , Edwige Dahouenon-Ahoussi  , Dominique CK Sohounhloue
Published: November 2022

The present study aims to assess the perception of fruit traders on plant species under anthropogenic threats in natural ecosystems of southern Benin. To do this, a semi-structured survey was conducted among fruit traders in local markets of Tangbo-Djevié and Dantokpa (Southern Benin). From the results obtained, it appears that the fruit sales activity is exclusively female (100%) and the majority of women (84.74%) are between 31 and 60 years old. According to surveyed people, fruit trade activities are closely depended on the fruiting period of each fruit species. Fruits sold in these markets are commonly pineapple (Ananas comosus), avocado (Persea americana), banana (Musa acuminata), soursop (Anona muricata), lemon (Citrus limon), orange (Citrus sinensis), grapefruit (Citrus maxima), papaya (Carica papaya), chapokin (Ceiba pentandra), guava (Psidium guajava), cinnamon apple (Annona squamosa), star apple (Chrysophylum albidum), wild apple (Irvingia gabonensis), black tamarind (Dialium guineense) and watermelon (Citrullus nanatus). The fruits sold in these markets came mainly from four departments of southern Benin, such as Atlantique, Zou, Couffo and Borgou. The fruits mostly cited by surveyed people as to be under anthropogenic threats are chapokin (Ceiba pentandra), soursop (Anona muricata), guava (Psidium guajava), cinnamon apple (Annona squamosa), star apple (Chrysophyllum albidum), wild apple (Irvingia gabonensis), mombin plum (Spondias mombin) and black tamarind (Dialium guineense). This study therefore shows that particular attention should be given to this activity sector through the awareness of the nutritional opportunity that these wild fruits represent for the population and also the development of technological processes allowing their real industrial valorization
Quality of Care: An Assessment of the Contributions of Osteopathic Medicine
Authors: Chila Anthony G.
Published: November 2022

Since the advent of Medicare in 1965, the concept of quality of care in medical practice in the United States has been under review, and a revision of ideas and responsibilities to the patient (consumer) has had a major impact on the system of delivery. In little, more than ten years, there have been major changes in the health care system in the United States, with a necessary delineation of the contributions to total health care of followers of two separate and distinct philosophies of medicine that are coexistent and recognized equally by the legislation of the United States. The purpose of this paper is to consider the quality of care rendered by the minority school of medicine through the services of the osteopathic community hospital and possible methods of improving it.
Clinical results from spine operations and expert interviews a multi center study
Authors: Ali Akbar , Khan Qaisar , Zeb Junaid , Hamid Muhammad Siddique , Saddique Muhammad Mudassir , Aziz Faiz Ul
Published: November 2022

Objective: This study aims to assess the short-term clinical results of spine procedures performed in a QHAMC, Nowshera, Pakistan. Methods: This study was conducted in orthopedic unit and neurosurgery unit of a QHAMC, Nowshera in Pakistan where this single-center investigation was carried out. The phrase "short-term clinical outcome" was used in this research to refer to the results of spine procedures within one week of the surgery. These results were broken down into three categories: Recovery, complications, and deaths. This particular research looked at a total of 208 different instances. In these patients, procedures such as Fenestration and discectomies, laminectomy, anterior cervical discectomies, and transpedicular fixations were performed. Results: Recovery was shown in terms of the muscle power restored in the limbs according to MRC scale criteria at the time of discharging each patient.
prevalence of abnormal lab results in pediatric patients at a hospital outpatient clinic
Authors: Haq Naeem Ul , Shah Syed Nasir , Ali Gohar , Haq Mian Iftikhar Ul , Khan Musawer , Shah Inayat , Ishaq Muhammad , Safi Akbar , Shoaib Muhammad
Published: November 2022

Objective: Examining the prevalence of different forms of birth defects and identifying their causes. Study design: Study Design: A cross-sectional study with retrospective analysis for causes. Place and duration of study: Department of Neurosurgery MMC hospital Mardan from 05 Jan 2021 to October 2021. Methods: All gender-neutral newborns seeking well-child care department of Neurosurgery MMC Mardan. Participating subjects were enlisted, and data were input and analyzed using SPSS v 22.0, regardless of whether they had received any prenatal care, or vaccinations, or were born with any observable abnormalities. Results: In our analysis of 497 individuals, 23% exhibited CNS congenital abnormalities. 47 children (9%) had gastrointestinal malformations, 111 had musculoskeletal anomalies, 42 had cardio-vascular anomalies, and 181 had genito-urinary anomalies. Extreme maternal age (less than 74 and more than 42 at conception), consanguinity, preterm deliveries, maternal smoking, and family history of birth abnormalities were similarly distributed across patients with diverse malformations. Genito-urinary abnormalities are the most common, followed by CNS and musculoskeletal anomalies.
“Caríssimo Dr. Zé”: os intercâmbios intelectuais e afetivos nas correspondências de José Américo de Almeida e sua professora de primeiras letras Julia Verônica dos Santos Leal
Authors: Burity Luiz Mário Dantas
Published: November 2022

José Américo de Almeida dedicou um espaço muito especial das suas memórias à sua professora de primeiras letras, ele dizia que por causa dela teria descoberto sua vocação para homem de letras. Ao passo em que, também ela dedicou a ele um espaço importante de sua imagem pública, seria reconhecida em sua velhice como a professora do ministro. O objetivo desse texto é discutir como a memória das aulas de primeiras letras foi agenciada por ambos ao longo das correspondências e de seus relatos autobiográficos. Isso significa observar os diferentes espaços sociais atribuídos aos intelectuais criadores, como os literatos, e às intelectuais mediadoras, no caso da professora de primeiras letras, conforme definem Angela de Castro Gomes e Patrícia Hansen (2016). Consideradas essas circunstâncias, foi possível observar um intercâmbio constante de memórias entre o político e a professora, o qual perdurou, em dezenas de cartas trocadas, por mais de duas décadas.