bluuebunny/crossref_metadata_2025 huggingface dataset:
Asymmetric C(sp2)H Activation
Authors: Wencel‐Delord Joanna , Colobert Françoise
Published: October 2013

A “niche” topic in the past decade, the asymmetric CH bond activation has been attracting growing interest over the last few years. Particularly significant advances have been achieved in the field of direct, stereoselective transformations of C(sp2)H bonds. This Concept article intends to showcase different types of asymmetric C(sp2)H bond activation reactions, emphasising both the nature of the stereo‐discriminating step and the variability of valuable scaffolds that could be rapidly constructed by means of such strategies.
Synthesis and Transistor Properties of Asymmetric Oligothiophenes: Relationship between Molecular Structure and Device Performance
Authors: An Tae Kyu , Jang Sang Hun , Kim Seul‐Ong , Jang Jaeyoung , Hwang Jihun , Cha Hyojung , Noh Young Ri , Yoon Soon Byung , Yoon Yong Jin , Kim Lae Ho , Chung Dae Sung , Kwon Soon‐Ki , Kim Yun‐Hi , Lee Sang‐Gyeong , Park Chan Eon
Published: October 2013

A series of three thiophene–naphthalene‐based asymmetric oligomers—5‐decyl‐2,2′:5′,2′′:5′′,2′′′‐quaterthiophene (DtT), 5‐decyl‐5′′‐(naphthalen‐2‐yl)‐2,2′:5′,2′′‐terthiophene (D3TN), and 5‐(4‐decylphenyl)‐5′‐(naphthalen‐2‐yl)‐2,2′‐bithiophene (DP2TN)—was synthesized by Suzuki cross‐coupling reactions. The long alkyl side chains improved both the solubility of the oligomers in solvents and their tendency to self‐assemble. UV/Vis absorption measurements suggested that DtT, D3TN, and DP2TN form H‐type aggregates with a face‐to‐face packing structure. In addition, the three oligomers were found to adopt vertically aligned crystalline structures in films deposited on substrates, as revealed by grazing‐incidence wide‐angle X‐ray scattering. These oligomers were used as the active layers of p‐type organic field‐effect transistors, and the resulting devices showed field‐effect mobilities of 3.3×10−3 cm2 V−1 s−1 for DtT, 1.6×10−2 cm2 V−1 s−1 for D3TN, and 3.7×10−2 cm2 V−1 s−1 for DP2TN. The differences in transistor performances were attributed to the degree of π overlap and the morphological differences determined by the molecular structures.
Size‐ and Orientation‐Selective Encapsulation of C70 by Cycloparaphenylenes
Authors: Iwamoto Takahiro , Watanabe Yoshiki , Takaya Hikaru , Haino Takeharu , Yasuda Nobuhiro , Yamago Shigeru
Published: October 2013

The size‐ and orientation‐selective formation of the shortest‐possible C70 peapod in solution and in the solid state by using the shortest structural unit of an “armchair” carbon nanotube (CNT), cycloparaphenylene (CPP), has been studied. [10]CPP and [11]CPP exothermically formed 1:1 complexes with C70, thereby giving the resulting peapods. A van′t Hoff plot analysis revealed that the formation of these complexes in 1,2‐dichlorobenzene was mainly driven by entropy, whereas the theoretical calculations suggested that the formation of the complex in the gas phase was predominantly driven by enthalpy. C70 was found to exist in two distinct orientations inside the CPP cavity, namely “lying” and “standing”, depending on the specific size of the CPP. The theoretical calculations and the X‐ray crystallographic analysis revealed that the interactions between [10]CPP and the short axis of C70 in its lying orientation were isotropic and similar to those observed between [10]CPP and C60. However, the interactions between [11]CPP and C70 in its standing orientation were anisotropic, thereby involving the radial deformation of [11]CPP into an ellipsoidal shape. This “induced fit” maximized the van der Waals interactions with the long axis of C70. Theoretical calculations revealed that the deformation occurred readily with low energy loss, thus suggesting that CPPs are highly radially elastic molecules. These results also indicate that the same type of radial deformation should occur in CNT peapods that encapsulate anisotropic fullerenes.
Probing DNA Mismatched and Bulged Structures by Using 19F NMR Spectroscopy and Oligodeoxynucleotides with an 19F‐Labeled Nucleobase
Authors: Tanabe Kazuhito , Tsuda Takuya , Ito Takeo , Nishimoto Sei‐ichi
Published: October 2013

In this study, DNA local structures with bulged bases and mismatched base pairs as well as ordinary full‐matched base pairs by using 19F NMR spectroscopy with 19F‐labeled oligodeoxynucleotides (ODNs) were monitored. The chemical shift change in the 19F NMR spectra allowed discrimination of the DNA structures. Two types of ODNs possessing the bis(trifluoromethyl)benzene unit (F‐unit) at specified uridines were prepared and hybridized with their complementary or noncomplementary strands to form matched, mismatched, or bulged duplexes. By using ODN F1, in which an F‐unit was connected directly to a propargyl amine‐substituted uridine, three local structures, that is, full‐matched, G–U mismatch, and A‐bulge could be analyzed, whereas other structures could not be discriminated. A molecular modeling study revealed that the F‐unit in ODN F1 interacted little with the nucleobases and sugar backbone of the opposite strand because the linker length between the F‐unit and the uridine base was too short. Therefore, the capacity of ODN F1 to discriminate the DNA local structures was limited. Thus, ODN F2 was designed to improve this system; aminobenzoic acid was inserted between the F‐unit and uridine base so the F‐unit could interact more closely with the opposite strand. Eventually, the G‐bulge and T–U mismatch and the three aforementioned local structures could be discriminated by using ODN F2. In addition, the dissociation processes of these duplexes could be monitored concurrently by 19F NMR spectroscopy.
Nickel‐Catalyzed Arylation, Alkenylation, and Alkynylation of Unprotected Thioglycosides at Room Temperature
Authors: Brachet Etienne , Brion Jean‐Daniel , Alami Mouad , Messaoudi Samir
Published: October 2013

Unprotected thioglycosides were effective nucleophiles for Ni0‐catalyzed CS bond‐forming reaction with functionalized (hetero)aryl, alkenyl, and alkynyl halides. The functional‐group tolerance on the electrophilic partner was typically high and the anomeric selectivities of the thioglycosides were high in all cases. The efficiency of this general procedure was well‐demonstrated by the synthesis of 4‐methyl‐7‐thioumbelliferyl‐β‐D‐cellobioside (MUS‐CB).
Conversion between Difluorocarbene and Difluoromethylene Ylide
Authors: Zheng Jian , Lin Jin‐Hong , Cai Ji , Xiao Ji‐Chang
Published: October 2013

The interconversion between difluoromethylene ylide and difluorocarbene is described. The difluoromethylene ylide precursor, Ph3P+CF2CO2−, could be turned into an efficient difluorocarbene reagent, whereas the classical difluorocarbene reagents, HCF2Cl and FSO2CF2CO2TMS, could generate highly reactive difluoromethylene ylide. Thus the Wittig difluoro‐olefination and difluorocyclopropanation could be selectively realized by using the same reagent. In addition, the ylides obtained from different carbene sources showed different reactivity in Wittig reactions.
ChemInform Abstract: High‐Pressure Synthesis and Characterization of BiCu3(Mn4‐xFex)O12 (x = 0, 1.0, 2.0) Complex Perovskites.
Authors: Kayser P. , Martinez‐Lope M. J. , Alonso J. A. , Sanchez‐Benitez J. , Fernandez M. T.
Published: October 2013

The series of title compounds is prepared from citrate precursors at 3.5 GPa and 1000 °C (1 h) in the presence of KClO4.
ChemInform Abstract: Synthesis, Crystal Structure and Properties of Mg3B36Si9C and Related Rare Earth Compounds RE3‐xB36Si9C (RE: Y, Gd—Lu).
Authors: Ludwig Thilo , Pediaditakis Alexis , Sagawe Vanessa , Hillebrecht Harald
Published: October 2013

Black single crystals of Mg3B36Si9C are synthesized from the elements at 1600 °C (h‐BN crucibles welded in Ta ampules, 40 h).
ChemInform Abstract: K[AsW2O9], The First Member of the Arsenate—Tungsten Bronze Family: Synthesis, Structure, Spectroscopic and Non‐Linear Optical Properties.
Authors: Alekseev Evgeny V. , et al. et al.
Published: October 2013

The title compound is synthesized by solid state reaction of KNO3, WO3, and (NH4)H2AsO4 in the molar ratio of 1:2:1 (Pt crucible, 773 and 1033 K for 24 h each).
ChemInform Abstract: Facile Carbon—Sulfur Bond Cleavage in Diarylsulfonium Ylides: A Catalytic Sulfur‐to‐Silicon Group Transfer.
Authors: Huang Xueliang , Goddard Richard , Maulide Nuno
Published: October 2013

An unusual cleavage of the non‐ylidic C—S bond of diaryl sulfonium ylides, e.g. (I) and (III), is reported.
ChemInform Abstract: Photoredox Activation for the Direct β‐Arylation of Ketones and Aldehydes.
Authors: Pirnot Michael T. , Rankic Danica A. , Martin David B. C. , MacMillan David W. C.
Published: October 2013

In the presence of cinchonidine a promising proof of concept for an asymmetric β‐arylation is achieved.
ChemInform Abstract: A Practical and Straightforward Access to Fluorinated Homoallylic Alcohols in Aqueous Media.
Authors: Lemonnier Gerald , Poisson Thomas , Couve‐Bonnaire Samuel , Pannecoucke Xavier
Published: October 2013

Indium‐mediated reaction of the fluoropropene (II) with different types of aldehydes gives fluorinated homoallylic alcohols in a brine solution.
ChemInform Abstract: (2S)‐2‐[(Phenylsulfinyl)methyl]pyrrolidine‐Catalyzed Efficient Stereoselective Michael Addition of Cyclohexanone and Cyclopentanone to Nitroolefins.
Authors: Singh Kamal Nain , Singh Paramjit , Kaur Amarjit , Singh Pushpinder , Sharma Sandeep Kumar , Khullar Sadhika , Mandal Sanjay K.
Published: October 2013

A newly designed catalyst SPS is described as highly efficient in the preparation of various γ‐nitro carbonyl compounds.
ChemInform Abstract: Synthesis of Iminonitriles by Oxone/TBAB‐Mediated One‐Pot Oxidative Three‐Component Strecker Reaction.
Authors: Gualtierotti Jean‐Baptiste , Schumacher Xavier , Wang Qian , Zhu Jieping
Published: October 2013

The optimized conditions render possible the preparation of a broad spectrum of title compounds as building blocks for different substance classes.
ChemInform Abstract: Fe‐Catalyzed Olefin Epoxidation with Tridentate Non‐Heme Ligands and Hydrogen Peroxide as the Oxidant.
Authors: Perandones Bernabe F. , del Rio Nieto Enrique , Godard Cyril , Castillon Sergio , De Frutos Pilar , Claver Carmen
Published: October 2013

The structure of the tridentate ligand is crucial for the effectivity and selectivity of the reaction.
ChemInform Abstract: Synthesis and Antioxidant Properties of Substituted 2‐Phenyl‐1H‐indoles.
Authors: Karaaslan Cigdem , Kadri Hachemi , Coban Tulay , Suzen Sibel , Westwell Andrew D.
Published: October 2013

The title compounds (III) (17 examples) are obtained via Fischer indole synthesis between substituted phenylhydrazine (I) and acetophenones (II).
ChemInform Abstract: Reactions of 4‐Oxobenz[1,3‐b]oxazinium Perchlorates with α‐Aminoazoles.
Authors: Zamigailo L. L. , Petrova O. N. , Shirobokova M. G. , Lipson V. V.
Published: October 2013

The reaction of oxazinium perchlorates (I) or (IV) with different aminoazoles is studied.
ChemInform Abstract: PEG Mediated Synthesis and Pharmacological Evaluation of Some Fluoro Substituted Pyrazoline Derivatives and Antiinflammatory and Analgesic Agents.
Authors: Jadhav Shravan Y. , Shirame Sachin P. , Kulkarni Suresh D. , Patil Sandeep B. , Pasale Sharad K. , Bhosale Raghunath B.
Published: October 2013

Novel fluoro‐substituted pyrazolinylpyrazoline derivatives are synthesized by PEG‐mediated reaction of chalcones (I) with hydrazine derivatives.
ChemInform Abstract: Synthesis of Polymerizable Vinyltriazoles: Development of an Optimized One‐Pot Strategy Starting from 4‐Bromobutyne.
Authors: Praud A. , Bootzeek O. , Blache Y.
Published: October 2013

Starting from 4‐bromobutyne, pathways for the selective synthesis of 4‐, and 5‐vinyl‐(1H)‐1,2,3,‐triazoles in aqueous media are developed using click chemistry.
ChemInform Abstract: Enantioselective Michael Addition of 4‐Hydroxycoumarins to β,γ‐Unsaturated α‐Oxophosphonates Catalyzed by a Bifunctional Squaramide Bearing a Structurally Rigid 9,10‐Ethylene‐9,10‐dihydroanthracene Skeleton.
Authors: Chang Xufang , Wang Qiaohui , Wang Youming , Song Haibin , Zhou Zhenghong , Tang Chuchi
Published: October 2013

The structurally rigid, new bifunctional squaramide organocatalyst shown demonstrates great advantages over previously reported thiourea or squaramide catalysts in terms of activity and enantioselectivity in the title Michael addition reaction.
ChemInform Abstract: An Efficient Synthesis of Novel Chromeno[3′,4′:5,6]pyrano[2,3‐b]indole Derivatives.
Authors: Chen Zhi‐Wei , Zhang Na , Wang Zhi‐Hua , Su Wei‐Ke
Published: October 2013

The substrates are prepared by a three‐component reaction as is demonstrated for example (IVa).
ChemInform Abstract: Synthesis and Alkylation of New 3‐Functionally Substituted Carbo[c]fused Pyridin‐2‐ones(thiones).
Authors: Dyachenko I. V. , Vovk M. V.
Published: October 2013

All products are purified by mere filtration and washing with water and ethanol.
ChemInform Abstract: Green Synthesis of Tetrahydropyrimidine Analogues and Evaluation of Their Antimicrobial Activity.
Authors: Darandale Sunil N. , Pansare Dattatraya N. , Mulla Nayeem A. , Shinde Devanand B.
Published: October 2013

A green, practical and facile approach for the synthesis of new tetrahydropyrimidine derivatives (IV) is developed using a ZrOCl2‐catalyzed multicomponent reaction.
ChemInform Abstract: Synthesis of Disulfides and Diselenides by Copper‐Catalyzed Coupling Reactions in Water.
Authors: Li Zhengkai , Ke Fang , Deng Hang , Xu Hualong , Xiang Haifeng , Zhou Xiangge
Published: October 2013

Aryliodides can be used as starting material as well.
ChemInform Abstract: Catalyst‐Free Mannich Reaction of Hydroxyanthraquinone: Facile Access to Emodin Mannich Bases and Anthraoxazines.
Authors: Zhao Li‐Ming , Zhang Li‐Ming , Ma Feng‐Yan , Wang Xiang‐Shan , Jin Hai‐Shan
Published: October 2013

The protocol allows the access to various Mannich bases which are required for structure—activity relationship studies.
ChemInform Abstract: Lanthanide Single‐Molecule Magnets
Authors: Woodruff Daniel N. , Winpenny Richard E. P. , Layfield Richard A.
Published: October 2013

Review: 211 refs.
ChemInform Abstract: Chemical Methods for Peptide and Protein Production
Authors: Chandrudu Saranya , Simerska Pavla , Toth Istvan
Published: October 2013

Review: 102 refs.
ChemInform Abstract: Synthetically Derived Auxiliaries: Phosphorus Derivatives
Authors: Juge S. , Malacea R. , Tessier A.
Published: October 2013

Review: 272 refs.
ChemInform Abstract: Metal‐Catalyzed Isomerization of Allylic and Propargylic Alcohols in Aqueous Media
Authors: Garcia‐Alvarez Joaquin , Garcia‐Garrido Sergio E. , Crochet Pascale , Cadierno Victorio
Published: October 2013

Review: 177 refs.
ChemInform Abstract: Catalytic X—H Insertion Reactions Based on Carbenoids
Authors: Gillingham Dennis , Fei Na
Published: October 2013

Review: 52 refs.
ChemInform Abstract: Transition Metal Catalyzed C—C Bond Formation via C—S Bond Cleavage: An Overview
Authors: Modha Sachin G. , Mehta Vaibhav P. , Van der Eycken Erik V.
Published: October 2013

Review: 60 refs.
ChemInform Abstract: Advances in the Enantioselective Synthesis of Carbocyclic Nucleosides
Authors: Boutureira Omar , Matheu M. Isabel , Diaz Yolanda , Castillon Sergio
Published: October 2013

Review: 60 refs.
ChemInform Abstract: Benign by Design: Catalyst‐Free In‐Water, On‐Water Green Chemical Methodologies in Organic Synthesis
Authors: Gawande Manoj B. , Bonifacio Vasco D. B. , Luque Rafael , Branco Paula S. , Varma Rajender S.
Published: October 2013

Review: 394 refs.
ChemInform Abstract: Advances in the Chemistry of Aminoisoxazole
Authors: Hamama Wafaa S. , Ibrahim Mona E. , Zoorob Hanafi
Published: October 2013

Review: 149 refs.
ChemInform Abstract: Azaphilonoids: Chemistry and Biology
Authors: Gao Jin‐Ming , Yang Sheng‐Xiang , Qin Jian‐Chun
Published: October 2013

Review: 391 refs.
ChemInform Abstract: Unusual Reactions Mediated by FMN‐Dependent Ene‐ and Nitro‐Reductases
Authors: Durchschein Katharina , Hall Melanie , Faber Kurt
Published: October 2013

Review: < 60 refs.
ChemInform Abstract: The Use of Siloxanes, Silsesquioxanes, and Silicones in Organic Semiconducting Materials
Authors: Kamino Brett A. , Bender Timothy P.
Published: October 2013

Review: 60 refs.
ChemInform Abstract: The Crystal Structure of Novel Silver Sulfogermanate Ag10Ge3S11.
Authors: Fedorchuk A. O. , Lakshminarayana G. , Tokaychuk Y. O. , Parasyuk O. V.
Published: October 2013

The title compound is synthesized from the elements (evacuated quartz tube, 1170 K, 6 h) and characterized by single crystal XRD.
ChemInform Abstract: Calcium Hexakis(dihydrogenphosphito)stannate(IV), Ca[Sn(H2PO2)6], with Some Remarks on the So‐Called Ge2(H2PO2)6 Structure Type.
Authors: Gieschen Tobias , Reuter Hans
Published: October 2013

Single crystals of Ca[Sn(H2PO2)6] form after a few days in a Petri dish containing solid SnF2 and few drops of H3PO2 at ambient conditions.
ChemInform Abstract: Syntheses of Spherical LiMn2O4 with Mn3O4 and Its Electrochemistry Performance.
Authors: Jiang Jianbing , Du Ke , Cao Yanbing , Peng Zhongdong , Hu Guorong , Duan Jiangu
Published: October 2013

Micro‐spherical LiMn2O4 particles are prepared from mixtures of Li2CO3 and helical spherical Mn3O4 in the ratio Li/Mn = 1.05:2 (750—850 °C, 12 h in air).
ChemInform Abstract: Rapid Oxidation of 1,2‐Diols, α‐Hydroxyketones and Some Alcohols Using N‐Bromosuccinimide in Ionic Liquid.
Authors: Khurana Jitender M. , Chaudhary Ankita , Kumar Sanjay
Published: October 2013

A facile and clean synthetic protocol for the oxidation of the title alcohols to corresponding carbonyl compounds using NBS is developed.
ChemInform Abstract: Z‐Stereoselective Semi‐Reduction of Alkynes: Modification of the Boland Protocol.
Authors: Mohamed Yasser M. A. , Hansen Trond Vidar
Published: October 2013

Modification of the Boland protocol for Z‐selective reduction of alkynes by adding TmsCl leads to short reaction times at ambient temperature, good yields, and high Z‐selectivity.
ChemInform Abstract: C—F Bond Formation with Fluoride Anions — Highly Selective Iodofluorination of Simple Allenes.
Authors: Xue Can , Jiang Xinpeng , Fu Chunling , Ma Shengming
Published: October 2013

The generated 2‐iodoalken3‐yl fluorides can be converted to their corresponding fluorinated alkynes and allenes.
ChemInform Abstract: Efficient Synthesis of 1,2‐Dicyclopropylethyne and (Cyclopropylethynyl)cyclobutane from 1,2‐Di‐(ω‐haloalkyl)ethynes and 1‐Cycloalkyl‐2‐(ω‐haloalkyl)ethynes.
Authors: Suri Suresh C. , Marcischak Jacob C.
Published: October 2013

A very efficient and cost effective method for the alkynylation of ω‐chloroalkyl tosylates is developed and applied to the synthesis of 1,2‐dicycloalkylethynes (IV) and (V).
ChemInform Abstract: Design and Synthesis of Polymeric Chiral Bicyclo[3.3.0]diene as Reusable Ligand for Rhodium‐Catalyzed Asymmetric 1,4‐Addition.
Authors: Yang Hongyu , Xu Minghua
Published: October 2013

The polymeric diene ligand proves satisfactory in the 1,4‐addition shown.
ChemInform Abstract: An Atom‐Economical and Stereoselective Domino Synthesis of Functionalized Dienes.
Authors: Souris Caroline , Luparia Marco , Frebault Frederic , Audisio Davide , Fares Christophe , Goddard Richard , Maulide Nuno
Published: October 2013

The title synthesis proceeds via an allylic alkylation/4π electrocyclic ring‐opening sequence.
ChemInform Abstract: Copper‐Catalyzed Trifluoromethylation of N,N‐Dialkylhydrazones.
Authors: Pair Etienne , Monteiro Nuno , Bouyssi Didier , Baudoin Olivier
Published: October 2013

A mild procedure for the conversion of N,N‐dialkylhydrazones of aromatic aldehydes to the corresponding trifluoromethyl ketohydrazones is developed based on the use of the readily available hypervalent iodine reagent (II).
ChemInform Abstract: Ruthenium‐Catalyzed ortho‐C—H Bond Alkylation of Aromatic Amides with α,β‐Unsaturated Ketones via Bidentate‐Chelation Assistance.
Authors: Rouquet Guy , Chatani Naoto
Published: October 2013

This methodology represents the first efficient utilization of enones in the ortho directed ruthenium‐catalyzed addition of C—H bonds to C—C double bonds.
ChemInform Abstract: Glycerol/CuI/Zn as a Recyclable Catalytic System for Synthesis of Vinyl Sulfides and Tellurides.
Authors: Goncalves Loren C. C. , Lima David B. , Borba Pedro M. Y. , Perin Gelson , Alves Diego , Jacob Raquel G. , Lenardao Eder J.
Published: October 2013

The coupling proceeds generally with high stereoselectivity and various functionalities are tolerated.
ChemInform Abstract: Electrochemical Synthesis and Characterization of Palladium Nanoparticles on Nafion—Graphene Support and Its Application for Suzuki Coupling Reaction.
Authors: Shendage Suresh S. , Patil Umakant B. , Nagarkar Jayashree M.
Published: October 2013

The reusable catalyst (5 times without significant loss of efficiency) is synthesized by electrochemical deposition.
ChemInform Abstract: Catalytic Asymmetric Direct Vinylogous Michael Addition of γ‐Aryl‐Substituted Deconjugated Butenolides to Nitroolefins and N‐Phenylmaleimide.
Authors: Kumar Vikas , Ray Bidisha , Rathi Preeti , Mukherjee Santanu
Published: October 2013

Reaction of γ‐butenolides (III) and (VI) with nitroolefins is carried out in the presence of the bifunctional cinchona thiourea derivative (I).
ChemInform Abstract: Intramolecular PdII‐Catalyzed Dehydrogenative C(sp3)—C(sp2) Coupling: An Alternative to Pd0‐Catalyzed C(sp3)—H Arylation from Aryl Halides?
Authors: Pierre Cathleen , Baudoin Olivier
Published: October 2013

It is demonstrated that the dehydrogenative C(sp2)‐H/C(sp3)‐H coupling is feasible to synthesize cyclopentane fused thiophenes.
ChemInform Abstract: Tertiary Amine Functionalized Polyacrylonitrile Fiber Catalyst for the Synthesis of Tetrahydrothiophenes.
Authors: Xu Changzhu , Du Jianguo , Ma Lichao , Li Guowei , Tao Minli , Zhang Wenqin
Published: October 2013

The newly developed title catalyst is successfully employed for the diastereoselective synthesis of tetrahydrothiophenes via tandem Michael/intramolecular Henry reactions between nitrostyrenes and 1,4‐dithiane‐2,5‐diol.
ChemInform Abstract: Efficient Synthesis of N‐Substituted Pyrroles Catalyzed by a Novel Organic—Inorganic Hybrid Solid Acid Catalyst.
Authors: Gao Lanchang , Bing Liu , Zhang Zehui , Kecheng Huang , Xiaoyun Hu , Deng Kejian
Published: October 2013

The solid acid catalyst is stable and can be recovered and reused without losing its activity.
ChemInform Abstract: Environmentally Friendly and Regioselective C3‐Alkylation of Indoles with Alcohols Through a Hydrogen Autotransfer Strategy.
Authors: Cano Rafael , Yus Miguel , Ramon Diego J.
Published: October 2013

The method can be applied to a broad substrate scope including primary and secondary alcohols.
ChemInform Abstract: An Expedient Approach for the Synthesis of Naphthyl Dispiro Pyrrolidine/Pyrrolizidine Through 1,3‐Dipolar Cycloaddition Reaction.
Authors: Saravanan Pasupathy , Pushparaj Sekar , Raghunathan Raghavachary
Published: October 2013

The formation of the required heterocyclic system proceeds with high regioselectivity.
ChemInform Abstract: Domino C—H Functionalization Reactions of gem‐Dibromoolefins Synthesis of N‐Fused Benzo[c]carbazoles.
Authors: Huang Richard Y. , Franke Patrick T. , Nicolaus Norman , Lautens Mark
Published: October 2013

The Pd‐catalyzed cyclization of gem‐dibromoolefins of type (I) is described to synthesize novel benzo[c]carbazoles derivatives (II).
ChemInform Abstract: Ruthenium Catalyzed Hydroaminoalkylation of Isoprene via Transfer Hydrogenation: Byproduct‐Free Prenylation of Hydantoins.
Authors: Schmitt Daniel C. , Lee Jungyong , Dechert‐Schmitt Anne‐Marie R. , Yamaguchi Eiji , Krische Michael J.
Published: October 2013

Isoprene is added to arylated hydantoins in the absence of a directing group.
ChemInform Abstract: Microwave Assisted Synthesis of 3,5‐Disubstituted 1,2,4‐Oxadiazoles from Substituted Amidoximes and Benzoyl Cyanides.
Authors: Kandre Shivaji , Bhagat Pundlik Rambhau , Sharma Rajiv , Gupte Amol
Published: October 2013

The simple protocol renders possible the synthesis of oxadiazoles including the complex structure (V) via O‐carboxyphenyl amidoxime intermediates.
ChemInform Abstract: New Anticancer Active and Selective Phenylene‐Bisbenzothiazoles: Synthesis, Antiproliferative Evaluation and DNA Binding.
Authors: Karminski‐Zamola Grace , et al. et al.
Published: October 2013

All synthesized compounds are tested for their antiproliferative effects on tumor cells.
ChemInform Abstract: Ln[N(SiMe3)2]3‐Catalyzed Cycloaddition of Terminal Alkynes to Azides Leading to 1,5‐Disubstituted 1,2,3‐Triazoles: New Mechanistic Features.
Authors: Hong Longcheng , Lin Weijia , Zhang Fangjun , Liu Ruiting , Zhou Xigeng
Published: October 2013

The first example of rare earth metal‐catalyzed cycloaddition of terminal alkynes (I) to azides (II) resulting in the formation of 1,5‐disubstituted 1,2,3‐triazoles (III) is described.
ChemInform Abstract: Microwave‐Assisted Synthesis of 3‐Methyl‐1‐phenylchromeno[4,3‐c]pyrazol‐4(1H)‐ones under Solvent‐Free Conditions.
Authors: Yang Guo‐Yu , Yang Jing‐Tian , Wang Cai‐Xia , Fan Su‐Fang , Xie Pu‐Hui , Xu Cui‐Lian
Published: October 2013

Compared with existing methods, this novel green and atom economical methodology for the synthesis of chromenopyrazolones (II) and (IV) affords the target products in higher yields and shorter reaction times.
ChemInform Abstract: Synthesis of Highly Substituted Isocoumarins by Rhodium‐Catalyzed Annulation of Readily Available Benzoic Acids.
Authors: Unoh Yuto , Hirano Koji , Satoh Tetsuya , Miura Masahiro
Published: October 2013

Rhodium‐catalyzed oxidative coupling of benzoic acid (I) with alkynes provides isocoumarin derivatives.
ChemInform Abstract: Pd‐Catalyzed Oxidative C—H/C—H Cross‐Coupling of Pyridines with Heteroarenes.
Authors: Liu Bo , Huang Yumin , Lan Jingbo , Song Feijie , You Jingsong
Published: October 2013

The authors present a highly selective C2‐heteroarylation of pyridines and related azines.
ChemInform Abstract: Tandem Synthesis of Pyrroloacridones via [3 + 2] Alkyne Annulation/Ring‐Opening with Concomitant Intramolecular Aldol Condensation.
Authors: Verma Akhilesh K. , Kotla Siva K. Reddy , Aggarwal Trapti , Kumar Sonu , Nimesh Hemlata , Tiwari Rakesh K.
Published: October 2013

An efficient cascade reaction is developed for the synthesis of functionalized biologically important pyrroloacridones starting from easily accessible iodo‐pyranoquinolines.
ChemInform Abstract: Novel and Chemoselective Dehydrogenation of 3,4‐Dihydropyrimidin‐2(1H)‐ones with 1,4‐Bis(triphenylphosphonium)‐2‐butene Peroxodisulfate.
Authors: Gorjizadeh Maryam
Published: October 2013

The present method tolerates a wide variety of functionalities, including oxidizable groups, cf.
ChemInform Abstract: Novel Synthetic Methodologies. Part 226. Synthesis of Dihydrobenzo[1,4]oxazines Using Copper‐Catalyzed Intramolecular Ring Closure Reaction.
Authors: Jangili Paramesh , Kashanna Jajula , Das Biswanath
Published: October 2013

The starting adducts are prepared by treatment of cyclic sulfamidates with 2‐halophenols following a known procedure.
ChemInform Abstract: Chiral β‐Iodoamines by Urea‐Catalyzed Iodocyclization of Trichloroacetimidates.
Authors: Brindle Cheyenne S. , Yeung Charles S. , Jacobsen Eric N.
Published: October 2013

The resulting products are converted to a variety of polyfunctional amine‐containing chiral building blocks.
ChemInform Abstract: In Search of 3d/4f‐Metal Single‐Molecule Magnets. Nickel(II)/Lanthanide(III) Coordination Clusters
Authors: Polyzou Christina D. , Efthymiou Constantinos G. , Escuer Albert , Cunha‐Silva Luis , Papatriantafyllopoulou Constantina , Perlepes Spyros P.
Published: October 2013

Review: 76 refs.
ChemInform Abstract: Alkaline‐Earth Metal Nitrides of the Main‐Group Elements: Crystal Structures and Properties of Inverse Perovskites
Authors: Niewa Rainer
Published: October 2013

Review: 137 refs.
ChemInform Abstract: Sweet Organometallics
Authors: Tschersich Sebastian , Boege Matthias , Schwidom Dirk , Heck Juergen
Published: October 2013

Review: 114 refs.
ChemInform Abstract: Recent Developments in Optical Resolution
Authors: Siedlecka Renata
Published: October 2013

Review: 129 refs.
ChemInform Abstract: Unique Properties of Chiral Biaryl‐based Secondary Amine Catalysts for Asymmetric Enamine Catalysis
Authors: Kano Taichi , Maruoka Keiji
Published: October 2013

Review: 67 refs.
ChemInform Abstract: Recent Advances in Dynamic Covalent Chemistry
Authors: Jin Yinghua , Yu Chao , Denman Ryan J. , Zhang Wei
Published: October 2013

Review: 50 refs.
ChemInform Abstract: Asymmetric Autocatalysis of Pyrimidyl Alkanol
Authors: Soai Kenso , Kawasaki Tsuneomi
Published: October 2013

Review: 58 refs.
ChemInform Abstract: Applications of Isatin Chemistry in Organic Synthesis and Medicinal Chemistry
Authors: Singh Girija S. , Desta Zelalem Y.
Published: October 2013

Review: 137 refs.
ChemInform Abstract: Moving Hydrogen Using Iron Catalysts
Authors: Morris Robert H.
Published: October 2013

Review: 23 refs.
ChemInform Abstract: Applications of Mass Spectrometry in Proteomics
Authors: Sokolowska Izabela , Ngounou Wetie Armand G. , Woods Alisa G. , Darie Costel C.
Published: October 2013

Review: 121 refs.
ChemInform Abstract: Nanostructured Catalysts via Metal Amide‐Promoted Smart Grafting
Authors: Liang Yucang , Anwander Reiner
Published: October 2013

Review: 271 refs.
ChemInform Abstract: Hall Mobility in Tin Iodide Perovskite CH3NH3SnI3: Evidence for a Doped Semiconductor.
Authors: Takahashi Yukari , Hasegawa Hiroyuki , Takahashi Yukihiro , Inabe Tamotsu
Published: October 2013

Crystals of the title compound are prepared by transferring EtOH into a flask containing stoichiometric quantities of SnI2 and MeNH3I (65 °C followed by cooling to 5 °C, 10—30% yield).
ChemInform Abstract: Magnetic Properties of the RbMnPO4 Zeolite‐ABW‐Type Material: A Frustrated Zigzag Spin Chain.
Authors: Nenert Gwilherm , Bettis Jerry Jr. , Kremer Reinhard , Yahia Hamdi Ben , Ritter Clemens , Gaudin Etienne , Isnard Olivier , Whangbo Myung‐Hwan
Published: October 2013

RbMnPO4 zeolite powder is prepared by solid state reaction of a stoichiometric mixture of Rb2CO3, MnO, and (NH4)H2PO4 (1.
ChemInform Abstract: Thermal Properties and Phase Transitions in (NH4)3ZrF7
Authors: Fokina V. D. , Gorev M. V. , Bogdanov E. V. , Pogoreltsev E. I. , Flerov I. N. , Laptash N. M.
Published: October 2013

heat capacity, thermal dilatation, permittivity, and T‐p phase diagram
ChemInform Abstract: KSi2P3: A New Layered Phosphidopolysilicate (IV).
Authors: Feng Kai , Kang Lei , Yin Wenlong , Hao Wenyu , Lin Zheshuai , Yao Jiyong , Wu Yicheng
Published: October 2013

The new title compound is synthesized by solid state reaction from mixtures of KP, Si, and P in the molar ratio of 1:2:2 (750 °C, 4 d).
ChemInform Abstract: Synthesis and Structure of Perovskite ScMnO3.
Authors: Chen Haiyan , Yu Tian , Gao Peng , Bai Jianming , Tao Jing , Tyson Trevor A. , Wang Liping , Lalancette Roger
Published: October 2013

Polycrystalline hexagonal ScMnO3 is prepared by solid state reaction of a stoichiometric mixture of Sc2O3 and MnO2 (calcination in air at 1000 °C, 10 h, intermittent sintering and annealing at 1100 °C, 10 h in O2).
ChemInform Abstract: Room Temperature and Solvent‐Free Iridium‐Catalyzed Selective Alkylation of Anilines with Alcohols.
Authors: Li Jia‐Qi , Andersson Pher G.
Published: October 2013

A novel bidentate iridium NHC‐phosphine complex is developed, which appears to be an efficient catalyst for the N‐alkylation of anilines with alcohols.
ChemInform Abstract: First Asymmetric Synthesis of Planar Chiral [2.2]Metacyclophanes.
Authors: Blangetti Marco , Mueller‐Bunz Helge , O'Shea Donal F.
Published: October 2013

The final enantioselective step is achieved using a (‐)‐sparteine mediated aryl lithiation, followed by treatment with various electrophiles.
ChemInform Abstract: A Cooperative Hydrogen‐Bond‐Promoted Organophotoredox Catalysis Strategy for Highly Diastereoselective, Reductive Enone Cyclization.
Authors: Neumann Matthias , Zeitler Kirsten
Published: October 2013

This new method gives trans‐1,2‐cycloalkanes and heterocycles providing the first example of combining photoredox approach with hydrogen‐bond catalysis.
ChemInform Abstract: (IPr)Pd(pydc) (pydc = Pyridine‐2,6‐dicarboxylate) — A Highly Active Precatalyst for the Sterically Hindered C—N Coupling Reactions.
Authors: Li Yan‐Jing , Zhang Jin‐Ling , Li Xiao‐Jian , Geng Yu , Xu Xiao‐Hua , Jin Zhong
Published: October 2013

Novel N‐heterocyclic carbene complexes incorporating a pyridine‐2‐carboxylate or pyridine‐2,6‐dicarboxylate ligand are synthesized and successfully applied as catalysts in the Buchwald—Hartwig amination reaction of sterically hindered aryl chlorides.
ChemInform Abstract: The Synthesis of α,α‐Difluoroacetamides via Electrophilic Fluorination in the Mixed‐Solvent of Water and PEG‐400.
Authors: Zhang Zhiguo , Bi Jingjing , Liu Qingfeng , Zhang Guisheng
Published: October 2013

In water/PEG‐400 the reactions proceed in nearly quantitative conversions within hours without the need of any additional phase transfer catalyst.
ChemInform Abstract: Application of Tartarate Derived Bidentate Bioxazolines in Enantioselective Addition of Terminal Alkynes to Imines.
Authors: Balaraman Kaluvu , Vasanthan Ravichandran , Kesavan Venkitasamy
Published: October 2013

A new class of bidentate bisoxazoline ligands is applied to the addition of alkynes to imines.
ChemInform Abstract: Trace Amount Cu (ppm)‐Catalyzed Intramolecular Cyclization of 2‐(gem‐Dibromovinyl)phenols(thiophenols) to 2‐Bromobenzofurans(thiophenes).
Authors: Ji Yong , Li Pinhua , Zhang Xiuli , Wang Lei
Published: October 2013

The required catalytic traces of copper species are already contained in commercially available cesium carbonate (Shanghai, 99.9%, Cu 47 ppm).
ChemInform Abstract: Organocatalytic Asymmetric Desymmetrization: Efficient Construction of Spirocyclic Oxindoles Bearing a Unique All‐Carbon Quaternary Stereogenic Center via Sulfa‐Michael Addition.
Authors: Yao Lu , Liu Kang , Tao Hai‐Yan , Qui Guo‐Fu , Zhou Xiang , Wang Chun‐Jiang
Published: October 2013

The bifunctional amine‐thiourea catalyst effects excellent stereoselectivities.
ChemInform Abstract: A Simple and Expeditious Synthesis of 2,3,6‐Trisubstituted Tetrahydropyrans Through (3,5)‐Oxonium‐ene Cyclization Using Molecular Iodine.
Authors: Raju N. Prudhvi , Reddy B. Jagan Mohan , Anjibabu R. , Muralikrishna K. , Reddy B. V. Subba
Published: October 2013

A simple and selective method allows the synthesis of tetrahydropyrane derivatives via iodine‐mediated coupling of aldehydes with hept‐5‐en‐2‐ols.
ChemInform Abstract: Catalytic Asymmetric Conjugate Addition of Grignard Reagents to Chromones.
Authors: Vila Carlos , Hornillos Valentin , Fananas‐Mastral Martin , Feringa Ben L.
Published: October 2013

The reaction takes advantage of the reduced reactivity of the resulting magnesium enolates, tolerating a broad scope of alkyl Grignards including secondary alkyl magnesium reagents.
ChemInform Abstract: Synthesis of a New Class of Tetronic Acid Derivatives: A One‐Pot Three‐Component Condensation Reaction Between Isoquinoline or Pyridine and Dialkyl Acetylenedicarboxylate with Tetronic Acid.
Authors: Rezayan Ali Hossein , Sabahi Hossein , Rahmati Abbas , Maleki Ali , Kheirjou Somayyeh
Published: October 2013

Tetronic acid derivatives [(IV) and (VI)] are smoothly synthesized via 1:1:1 addition reaction.
ChemInform Abstract: Novel Quinolone Substituted Thiazolidin‐4‐ones as Antiinflammatory, Anticancer Agents: Design, Synthesis and Biological Screening.
Authors: Suthar Sharad Kumar , Jaiswal Varun , Lohan Sandeep , Bansal Sumit , Chaudhary Anil , Tiwari Amit , Alex Angel Treasa , Joesph Alex
Published: October 2013

The title compounds are tested for their anti‐inflammatory and anticancer activity.
ChemInform Abstract: Tetrahydroquinolines by Lewis Acid‐Promoted Friedel—Crafts Cyclizations.
Authors: Bunce Richard A. , Cain Nicholas R. , Cooper John G.
Published: October 2013

Use of FeCl3 as Lewis acid promoter proves to be superior for unsubstituted and alkyl‐substituted substrates, whereas more reactive AlCl3 is necessary for substrates possessing heteroatom functionality.
ChemInform Abstract: Thermal Induced Intramolecular [2 + 2] Cycloaddition of Allene‐ACPs.
Authors: Chen Kai , Sun Run , Xu Qin , Wei Yin , Shi Min
Published: October 2013

A facile protocol for preparation of bicyclo[4.2.0] heterocycles containing a nitrogen atom is developed starting from allene‐alkylidenecyclopropanes.
ChemInform Abstract: Synthesis and Anticancer Activity of Novel 2‐Pyridyl Hexahydrocyclooctathieno[2,3‐d]pyrimidine Derivatives.
Authors: Kassab Asmaa E. , Gedawy Ehab M.
Published: October 2013

The synthesis of the titled compounds along with their anticancer activities against various cancer‐cell lines is described.
ChemInform Abstract: Unveiling Latent α‐Iminocarbene Reactivity for Intermolecular Cascade Reactions Through Alkyne Oxidative Amination.
Authors: Mace Nina , Thornton Aaron R. , Blakey Simon B.
Published: October 2013

The present protocol provides a metallonitrene/alkyne cascade which is terminated by ylide formation and [2,3] Wittig rearrangement.
ChemInform Abstract: The Development of Solid‐Phase Microextraction Fibers with Metal Wires as Supporting Substrates
Authors: Feng Juanjuan , Qiu Hongdeng , Liu Xia , Jiang Shengxiang
Published: October 2013

Review: 102 refs.
ChemInform Abstract: Carbon Nanotubes: In Chromatography Preparation
Authors: Ramos Maria Asensio , Herrera‐Herrera Antonio V. , Rodriguez Delgado Miguel Angel , Fanali Salvatore , Hernandez‐Borges Javier
Published: October 2013

Review: 42 refs.
ChemInform Abstract: Rational Design of New Molecules of Biological Significance from Phenolic Constituents of Some Tropical Plants as Renewable Materials
Authors: Kouznetsov Vladimir V. , Arenas Diego R. Merchan , Ruiz Fernando A. Rojas , Mendez Leonor Y. Vargas
Published: October 2013

Review: 141 refs.
ChemInform Abstract: Orthogonality in Discrete Self‐Assembly — Survey of Current Concepts
Authors: Saha Manik Lal , De Soumen , Pramanik Susnata , Schmittel Michael
Published: October 2013

Review: <180 refs.
ChemInform Abstract: Synthesis of Binaphthyl Based Phosphine and Phosphite Ligands
Authors: Pereira Mariette M. , Calvete Mario J. F. , Carrilho Rui M. B. , Abreu Artur R.
Published: October 2013

Review: 241 refs.
ChemInform Abstract: C—H···O Non‐classical Hydrogen Bonding in the Stereomechanics of Organic Transformations: Theory and Recognition
Authors: Johnston Ryne C. , Cheong Paul Ha‐Yeon
Published: October 2013

Review: 90 refs.
ChemInform Abstract: Grignard Reactions Involving Halogenated Pyrimidines
Authors: Delia Thomas J.
Published: October 2013

Review: 47 refs.
ChemInform Abstract: Antibacterial Action of Quinolones: From Target to Network
Authors: Cheng Guyue , Hao Haihong , Dai Menghong , Liu Zhenli , Yuan Zonghui
Published: October 2013

Review: 99 refs.
ChemInform Abstract: Gold‐Catalyzed Intermolecular Enantioselective [2 + 2] Cycloadditions of Sulfonylallenamides and Styrenes
Authors: Mauleon Pablo
Published: October 2013

Review: 21 refs.
ChemInform Abstract: Synthesis of Selenium Compounds by Free Radical Addition Based on Visible‐light‐activated Se—Se Bond Cleavage
Authors: Nomoto Akihiro , Higuchi Yoshihiro , Kobiki Yohsuke , Ogawa Akiya
Published: October 2013

Review: 37 refs.
ChemInform Abstract: Molecular Characterization of Collagen Hydroxylysine O‐Glycosylation by Mass Spectrometry: Current Status
Authors: Perdivara Irina , Yamauchi Mitsuo , Tomer Kenneth B.
Published: October 2013

Review: 56 refs.
ChemInform Abstract: A Medicinal Chemists′ Guide to the Unique Difficulties of Lead Optimization for Tuberculosis
Authors: Dartois Veronique , Barry Clifton E. III
Published: October 2013

Review: 108 refs.
ChemInform Abstract: Peripherally Restricted CB1 Receptor Blockers
Authors: Chorvat Robert J.
Published: October 2013

Review: 85 refs.
ChemInform Abstract: Organic Stereochemistry. Part 8. Prostereoisomerism and the Concept of Product Stereoselectivity in Biochemistry and Xenobiotic Metabolism
Authors: Testa Bernard
Published: October 2013

Review: 114 refs.
ChemInform Abstract: Functionalization of Porous Carbons for Catalytic Applications
Authors: Figueiredo Jose Luis
Published: October 2013

Review: 101 refs.
ChemInform Abstract: Catalysis Science of Supported Vanadium Oxide Catalysts
Authors: Wachs Israel E.
Published: October 2013

Review: 50 refs.
ChemInform Abstract: Some Turning Points in the Chemical Electron Microscopic Study of Heterogeneous Catalysts
Authors: Thomas John Meurig , Ducati Caterina , Leary Rowan , Midgley Paul A.
Published: October 2013

Review: 91 refs.
Synthesis and Preliminary Evaluation of 1‐[18F]Fluoro‐1‐deoxy‐2,5‐anhydro‐D‐mannitol as a PET Radiotracer for Breast Cancer Imaging
Authors: Niu Ben , Wen Xiaoan , Jia Zhijun , Wu Xiaoming , Guo Wanhua , Sun Hongbin
Published: October 2013

1‐[18F]Fluoro‐1‐deoxy‐2,5‐anhydro‐D‐mannitol (3, 18F‐FDAM) has been synthesized in 6 steps starting from 2,5‐anhydro‐D‐mannitol (2,5‐AM) and evaluated as a new radiotracer for PET imaging of MCF‐7 breast tumor. The result of PET imaging study showed that 3 displayed a slightly higher uptake by breast tumor in comparison with the normal breast tissue, implying the possibility of development of PET radiotracers based on targeting fructose transporters.
Remembrance of Hugh E. Huxley, a founder of our field
Authors: Pollard Thomas D. , Goldman Yale E.
Published: October 2013

Hugh E. Huxley (1924–2013) carried out structural studies by X‐ray fiber diffraction and electron microscopy that established how muscle contracts. Huxley's sliding filament mechanism with an ATPase motor protein taking steps along an actin filament, established the paradigm not only for muscle contraction but also for other motile systems using actin and unconventional myosins, microtubules and dynein and microtubules and kinesin. © 2013 Wiley Periodicals, Inc.
Cost effectiveness of proton therapy compared with photon therapy in the management of pediatric medulloblastoma
Authors: Mailhot Vega Raymond B. , Kim Jane , Bussière Marc , Hattangadi Jona , Hollander Abby , Michalski Jeff , Tarbell Nancy J. , Yock Torunn , MacDonald Shannon M.
Published: October 2013

BACKGROUND

Proton therapy has been a hotly contested issue in both scientific publications and lay media. Proponents cite the modality's ability to spare healthy tissue, but critics claim the benefit gained from its use does not validate its cost compared with photon therapy. The objective of this study was to evaluate the cost effectiveness of proton therapy versus photon therapy in the management of pediatric medulloblastoma.

METHODS

A cost‐effective analysis was performed from the societal perspective using a Monte Carlo simulation model. A population of pediatric medulloblastoma survivors aged 18 years was studied who had received treatment at age 5 years and who were at risk of developing 10 adverse events, such as growth hormone deficiency, coronary artery disease, ototoxicity, secondary malignant neoplasm, and death. Costing data included the cost of investment and the costs of diagnosis and management of adverse health states from institutional and Medicare data. Longitudinal outcomes data and recent modeling studies informed risk parameters for the model. Incremental cost‐effectiveness ratios were used to measure outcomes.

RESULTS

Results from the base case demonstrated that proton therapy was associated with higher quality‐adjusted life years and lower costs; therefore, it dominated photon therapy. In 1‐way sensitivity analyses, proton therapy remained the more attractive strategy, either dominating photon therapy or having a very low cost per quality‐adjust life year gained. Probabilistic sensitivity analysis illustrated the domination of proton therapy over photon therapy in 96.4% of simulations.

CONCLUSIONS

By using current risk estimates and data on required capital investments, the current study indicated that proton therapy is a cost‐effective strategy for the management of pediatric patients with medulloblastoma compared with standard of care photon therapy. Cancer 2013;119:4299–4307. © 2013 American Cancer Society.
Treatment trade‐offs in myeloma: A survey of consecutive patients about contemporary maintenance strategies
Authors: Burnette Brian L. , Dispenzieri Angela , Kumar Shaji , Harris Ann M. , Sloan Jeff A. , Tilburt Jon C. , Kyle Robert A. , Rajkumar S. Vincent
Published: October 2013

BACKGROUND

Two randomized trials have demonstrated improved progression‐free survival (PFS) with lenalidomide maintenance after autologous transplantation for multiple myeloma (MM). Overall survival (OS) results are conflicting, and quality‐of‐life (QOL) data are lacking. The authors conducted a systematic survey of patients with MM regarding what constitutes a meaningful benefit that would make burdens of maintenance treatments (toxicity and cost) acceptable.

METHODS

A self‐administered survey was mailed to 1159 consecutive, living patients who were evaluated at Mayo Clinic. The survey provided background information on the standard of care for MM and data on maintenance. Patients were asked to estimate the magnitude of OS benefit that would be acceptable for various degrees of toxicity and cost.

RESULTS

Of 1159 surveys sent, 886 patients (83.2%) responded, and 736 patients returned a completed survey (66% raw response rate). The most worrisome potential toxicity was identified as peripheral neuropathy by 27% of patients, cytopenias by 24%, deep vein thrombosis by 20%, fatigue by 15%, nausea by 8%, and diarrhea/constipation by 7%. If treatment was free, had no toxicity, and the OS benefit was ≤1 year, then 49% of patients indicated that they would choose maintenance; with moderate toxicity, this proportion decreased to 42%. Adding a treatment cost of $25 per month decreased the proportion that would choose maintenance to 39% of patients.

CONCLUSIONS

The current results indicated that willingness to receive maintenance treatment declined when actual benefits were provided in concrete numeric terms compared with a general statement of PFS benefit. The authors also observed that the magnitude of benefit required to consider maintenance was affected by cost and toxicity. Cancer 2013;119:4308–4315. © 2013 American Cancer Society.
Bevacizumab (BVZ)‐associated toxicities in children with recurrent central nervous system tumors treated with BVZ and irinotecan (CPT‐11)
Authors: Fangusaro Jason , Gururangan Sridharan , Poussaint Tina Young , McLendon Roger E. , Onar‐Thomas Arzu , Warren Katherine E. , Wu Shengjie , Packer Roger J. , Banerjee Anu , Gilbertson Richard J. , Jakacki Regina , Gajjar Amar , Goldman Stewart , Pollack Ian F. , Friedman Henry S. , Boyett James M. , Kun Larry E. , Fouladi Maryam
Published: October 2013

BACKGROUND

The incidence and spectrum of acute toxicities related to the use of bevacizumab (BVZ)‐containing regimens in children are largely unknown. This report describes the adverse events in a recently completed large phase 2 trial of BVZ plus irinotecan (CPT‐11) in children with recurrent central nervous system tumors.

METHODS

Pediatric Brain Tumor Consortium trial‐022 evaluated the efficacy and toxicity of BVZ (10 mg/kg administered intravenously) as a single agent for 2 doses given 2 weeks apart and then combined with CPT‐11 every 2 weeks (1 course = 4 weeks) in children with recurrent central nervous system tumors. Children were treated until they experienced progressive disease, unacceptable toxicity or completed up to a maximum of 2 years of therapy. Toxicities were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events, version 3.0. Patients who received at least 1 dose of BVZ were included for toxicity assessment.

RESULTS

Between October 2006 and June 2010, 92 patients evaluable for toxicity were enrolled and received 687 treatment courses. The most common toxicities attributable to BVZ included grade I‐III hypertension (38% of patients), grade I‐III fatigue (30%), grade I‐II epistaxis (24%), and grade I‐IV proteinuria (22%). Twenty‐two patients (24%) stopped therapy due to toxicity.

CONCLUSIONS

The combination of BVZ and CPT‐11 was fairly well‐tolerated, and most severe BVZ‐related toxicities were rare, self‐limiting, and manageable. Cancer 2013;119:4180–4187. ©2013 American Cancer Society.