bluuebunny/crossref_metadata_2025 huggingface dataset:
Respect Is Central: A Critical Review of Implementation Frameworks for Continuous Quality Improvement in Aboriginal and Torres Strait Islander Primary Health Care Services
Authors: Redman-MacLaren Michelle , Turner (Anmatyerre/Jaru) Nalita Nungarrayi , Taylor Judy , Laycock Alison , Vine Kristina , Thompson (Gurindji) Quitaysha , Larkins Sarah , Carlisle Karen , Thompson Sandra , Bailie Ross , Matthews (Quandamooka) Veronica
Published: July 2021

Background: Primary health care (PHC) services are complex systems, shaped by an interplay of factors at individual, organisational and broader system levels. For Aboriginal and Torres Strait Islander PHC services, closer relationships with the people they serve, local knowledge of community, and cultural awareness are critical. Continuous quality improvement (CQI) has proven to be an effective process for identification of priority issues in health care delivery and for instigating the design, implementation and evaluation of improvement interventions in these settings. However, wide-scale variation in care quality persists partly due to the mismatch between CQI interventions and context.

Methods: This critical review of implementation frameworks for CQI in Aboriginal and Torres Strait Islander primary health care was conducted in two phases: (1) a review of primary published implementation frameworks used in PHC contexts, and (2) a comparison of key features of these frameworks with quality concepts identified by high-improving Aboriginal and Torres Strait Islander PHC services in remote Australia.

Results: We found nine primary implementation frameworks previously used in PHC contexts guiding interventions within and between macro (broader contextual) level; meso (health service) level; and micro (community and inter-personal) level systems. There was commonality between these frameworks and key quality concepts in Aboriginal and Torres Strait Islander PHC. However, none of the frameworks covered all concepts with rare consideration of communities driving health improvement, two-way learning (integrating cultural knowledge into healthcare provision), and caring staff—engendering trusting relationships with community enacted through respect.

Conclusion: Respect, as a secret essence, privileges the importance of culture, and is an essential element of CQI implementation frameworks for positive change in Aboriginal and Torres Strait Islander PHC services. It is essential to work with communities to design workforce models that grow a caring stable workforce to ensure improvements in quality of care that are effective for their context.
Prevalence and Correlation Analysis of Soil-Transmitted Helminths Infections and Treatment Coverage for Preschool and School Aged Children in Kenya: Secondary Analysis of the National School Based Deworming Program Data
Authors: Okoyo Collins , Campbell Suzy J. , Minnery Mark , Owaga Chrispin , Onyango Nelson , Medley Graham , Mwandawiro Charles
Published: July 2021

Background:Soil-transmitted helminths (STH) are among the most common parasitic infections globally, disproportionately affecting children. Treatment of STH in Kenya is often targeted at preschool (PSAC) and school aged (SAC) children delivered through annual mass drug administration (MDA) in primary schools. Understanding group-specific prevalence and dynamics between treatment and coverage is critical for continued treatment success. This study aims to provide detailed information on group-specific infection prevalence and relative reductions (RR), and their relationships with treatment coverage over time. Additionally, it aims to quantify the correlation between the observed school level infection prevalence and treatment coverage.

Methods:Secondary analysis of existing data collected between 2012 and 2018 by the monitoring and evaluation (M&E) program of the National School-Based Deworming (NSBD) program was used. The M&E program conducted surveys utilizing cross-sectional study design, at four survey time points, in a nationally-representative sample of schoolchildren across counties in Kenya. In each participating school, the program randomly sampled 108 children per school, of both groups. Infection prevalence was estimated using binomial regression, RR in prevalence using multivariable mixed effects model, statistical correlations using structural equation modeling, and change-point-analysis using the binary segmentation algorithm.

Results:Overall, STH prevalence for PSAC was 33.7, 20.2, 19.0, and 17.9% during Year 1 (Y1), Year 3 (Y3), Year 5 (Y5), and Year 6 (Y6) surveys, respectively with an overall RR of 46.9% (p= 0.001) from Y1 to Y6. Similarly, overall STH prevalence for SAC was 33.6, 18.4, 14.7, and 12.5% during Y1, Y3, Y5, and Y6 surveys, respectively with an overall RR of 62.6% (p< 0.001). An overall (all time points) significant but very weak negative correlation was found between treatment coverage and undifferentiated STH prevalence (r= −0.144,p= 0.002) among PSAC but not in SAC. Further, we observed inter-county heterogeneity variation in infection prevalence, RR, as well as correlations.

Conclusion:The analysis showed that after six rounds of MDA, prevalence of STH has significantly declined among both groups of children, however not to a point where it is not a public health problem (below 1%). The analysis, additionally established an overall significant but weak negative correlation between treatment coverage and prevalence, indicating that the current treatment coverage might not be sufficient to drive the overall STH prevalence to below 1%. These findings will allow STH control programs in Kenya to make decisions that will accelerate the attainment of STH elimination as a public health problem.
Supporting Child Development Through Parenting Interventions in Low- to Middle-Income Countries: An Updated Systematic Review
Authors: Zhang Linlin , Ssewanyana Derrick , Martin Marie-Claude , Lye Stephen , Moran Greg , Abubakar Amina , Marfo Kofi , Marangu Joyce , Proulx Kerrie , Malti Tina
Published: July 2021

Background: Over 250 million children in low- and middle-income countries are at risk of not achieving their fullest developmental potential due to co-occurring risks such as poor nutrition and inadequate learning opportunities. Early intervention programs integrating the aspects of nurturing care, that is, good health, adequate nutrition, safety and security, responsive caregiving, and learning opportunities, may ameliorate against the negative impact of these adverse conditions.

Methods: This meta-analytic review updates the evidence base of parenting interventions comprising stimulation and responsive caregiving components on developmental outcomes for children under age 2 years in low- and middle-income countries. It also describes and assesses the moderation effects of population characteristics and implementation features on the intervention effectiveness. Studies were identified based on previous systematic reviews and an updated literature search in eight databases and the gray literature up to December 2020. A random-effect model was used to explore the pooled effect sizes accounted for by the intervention for developmental outcome of cognition, language, motor, and social-emotional capacities. Exploratory moderation analyses were also conducted.

Results: Twenty-one randomized controlled trials representing over 10,400 children from 12 low- and middle-income countries and regions across three continents (Africa, Latin America, and Asia) were identified. The interventions showed overall small-to-moderate effects on children's cognitive development (ES = 0.44; 95% CI = [0.30, 0.57]); language development (ES = 0.33; 95% CI = [0.18, 0.49]); and motor skills (ES = 0.21; 95% CI = [0.10, 0.32]). The overall effect on social-emotional development was non-significant (ES = 0.17; 95% CI = [−0.01, 0.34]). Effect sizes (ES) varied significantly across the studies. Parenting programs that targeted vulnerable groups, including rural communities and caregivers with lower education levels, had more significant effects on children's development. Group sessions (vs. individual visits) and high program dose (≥12 sessions) were also associated with stronger effects on child development. Further research is needed to determine the effectiveness of the workforce and training on programmatic outcomes.

Conclusion: The findings indicate that parenting interventions that encourage nurturing care are effective in improving the early development of children, especially among vulnerable populations. We discuss opportunities to strengthen the implementation of research-based parenting interventions in such contexts.
Non-pharmacological Approaches to Depressed Elderly With No or Mild Cognitive Impairment in Long-Term Care Facilities. A Systematic Review of the Literature
Authors: Gramaglia Carla , Gattoni Eleonora , Marangon Debora , Concina Diego , Grossini Elena , Rinaldi Carmela , Panella Massimiliano , Zeppegno Patrizia
Published: July 2021

Introduction: Compared to old people who live at home, depressive symptoms are more prevalent in those who live in long-term care facilities (LTCFs). Different kinds of non-pharmacological treatment approaches in LTCFs have been studied, including behavioral and cognitive-behavioral therapy, cognitive bibliotherapy, problem-solving therapy, brief psychodynamic therapy and life review/reminiscence. The aim of the current review was to systematically review non-pharmacological treatments used to treat depressed older adults with no or mild cognitive impairment (as described by a Mini Mental State Examination score > 20) living in LTCFs.

Methods: A research was performed on PubMed and Scopus databases. Following the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA) flowchart, studies selection was made. The quality of each Randomized Controlled Trial was scored using the Jadad scale, Quasi-Experimental Design studies and Non-Experimental studies were scored based on the Newcastle-Ottawa Scale (NOS)

Results: The review included 56 full text articles; according to the type of intervention, studies were grouped in the following areas: horticulture/gardening (n = 3), pet therapy (n = 4), physical exercise (n = 9), psychoeducation/rehabilitation (n = 15), psychotherapy (n = 3), reminiscence and story sharing (n = 14), miscellaneous (n = 8).

Discussion and Conclusion: Despite mixed or negative findings in some cases, most studies included in this systematic review reported that the non-pharmacological interventions assessed were effective in the management of depressed elderly in the LTCFs context. Regrettably, the limitations and heterogeneity of the studies described above hinder the possibility to generalize and replicate results.
Anticandidal Activities by Lactobacillus Species: An Update on Mechanisms of Action
Authors: Vazquez-Munoz Roberto , Dongari-Bagtzoglou Anna
Published: July 2021

Lactobacilli are among the most studied bacteria in the microbiome of the orodigestive and genitourinary tracts. As probiotics, lactobacilli may provide various benefits to the host. These benefits include regulating the composition of the resident microbiota, preventing – or even potentially reverting- a dysbiotic state. Candida albicans is an opportunistic pathogen that can influence and be influenced by other members of the mucosal microbiota and, under immune-compromising conditions, can cause disease. Lactobacillus and Candida species can colonize the same mucosal sites; however, certain Lactobacillus species display antifungal activities that can contribute to low Candida burdens and prevent fungal infection. Lactobacilli can produce metabolites with direct anticandidal function or enhance the host defense mechanisms against fungi. Most of the Lactobacillus spp. anticandidal mechanisms of action remain underexplored. This work aims to comprehensively review and provide an update on the current knowledge regarding these anticandidal mechanisms.
Diverging Water Ages Inferred From Hydrodynamics, Hydrochemical and Isotopic Tracers in a Tropical Andean Volcano-Sedimentary Confined Aquifer System
Authors: Manciati Carla , Taupin Jean Denis , Patris Nicolas , Leduc Christian , Casiot Corinne
Published: July 2021

Hydrogeology in the Andes cordillera reflects its complex geological history. In most cases, groundwater flows through fractures and faults that compartmentalize the volcanic material, and through the primary porosity of the volcano-sedimentary material. The volcanic mineral context and geothermal environment mark the groundwater chemistry, especially in the high concentrations of specific trace elements. This study focuses on the complex system of the Tumbaco – Cumbayá – Los Chillos aquifer, in the vicinity of the Ilaló volcano near Quito (Ecuador). Hydrodynamic, geochemical and isotopic tools were used to assess the chemical characteristics of water and its origin, identify the recharge areas, and estimate the transit time of water using simple methods and scarce data. Results revealed two distinct aquifers, one in the volcanic cone located in the center of the study area, and the other in the volcano-sedimentary series of the Tumbaco – Cumbayá – Los Chillos valley. The volcanic aquifer is characterized by a high mineralization, a recharge zone between 2400 m asl and 3100 m asl, and radiocarbon concentrations lower than 20 pmc. The volcano-sedimentary aquifer seems to behave as a partly disconnected system, between the north and the south of Ilaló volcano, and also with a great heterogeneity, maybe due to the presence of lenses of volcanic ash. It has an intermediate mineralization, a mean recharge zone between 2,300 and 2,700 m asl, and 14C activities between 45.4 and 87.4 pmc in apparent contradiction with the hydrodynamic mass balance.
Terrestrial Slugs in Neotropical Agroecosystems
Authors: Ramos Mariangie , Gomes Suzete Rodrigues , Gutierrez Yashira , Ramos-Rodriguez Olgaly , Uzeda Mariella Carmadelli
Published: July 2021

Slugs can be important agricultural pests in tropical regions. They are also intermediate hosts of parasitic nematodes, such asAngiostrongylus costaricensisandA. cantonensis, which can cause abdominal and cerebral angiostrongyliasis in humans. Management of slugs in conventional agriculture has relied heavily in the use of pellets containing metaldehyde. In this article, we review cases of slug problems and their management in neotropical agroecosystems.
Selection of Elite Genotypes of Coffee arabica L. to Produce Specialty Coffees
Authors: Malta Marcelo Ribeiro , Oliveira Antonio Carlos Baiao , Liska Gilberto Rodrigues , Carvalho Gladyston Rodrigues , Pereira Antonio Alves , Silva Ackson Dimas , Alvaro Laisa Nayara , Mota Diego Menez
Published: July 2021

This study aimed to evaluate the cup quality of Coffea arabica elite genotypes submitted to wet processing. C. arabica elite genotypes, which were grouped according to their genealogy: Bourbon, Paraíso Germplasm, and Resistant to Rust. Coffees were sent to wet processing to obtain fully washed coffee. After processing and drying the coffees were subjected to cup quality analysis according to the methodology of the Association of Special Coffees (SCA). To characterize and discriminate the genealogical groups the data were submitted to chemometric analysis, Principal Component Method (PCA) and Partial Least Squares Discriminant Analysis (PLS-DA). The PCA was effective in presenting an overview of the data, demonstrating the variables that most contributed to the analysis response. However, the PCA was not efficient to group genotypes according to their genealogical origin, based on chemometric data, as it is an unsupervised analysis. Even though most of the samples were classified correctly, the PLS-DA model created has not yet managed to correctly classify the genotypes of the Paraíso germplasm group. The C. arabica elite genotypes evaluated have the potential to produce special coffees, especially on the genotypes Paraíso 2, H493-1-2-10 and UFV-7158 with scores equal to or above 90 points.
Genetic Characteristics and Pathogenicity of a Novel Porcine Deltacoronavirus Southeast Asia-Like Strain Found in China
Authors: Wang Hejie , Qin Yibin , Zhao Wu , Yuan Tingting , Yang Chunjie , Mi Xue , Zhao Ping , Lu Ying , Lu Bingxia , Chen Zhongwei , He Ying , Yang Cui , Yi Xianfeng , Wu Zhuyue , Chen Ying , Wei Zuzhang , Huang Weijian , Ouyang Kang
Published: July 2021

Farmers involved in the lucrative pork trading business between China and Southeast Asian countries should be aware of a recently discovered novel porcine deltacoronavirus (PDCoV) in Guangxi province, China. A PDCoV strain, CHN/GX/1468B/2017, was isolated from the small intestinal contents of piglets with diarrhea from this region, with a titer of 1 × 108.0 TCID50/mL on LLC-PK cells. The full-length genome sequence consists of 25,399 nt as determined by next-generation sequencing and this was deposited in the GenBank (accession number MN025260.1). Genomic analysis showed that CHN/GX/1468B/2017 strain had 96.9~99.4% nucleotide homology with other 87 referenced PDCoV strains from different areas, and contained 6 and 9-nt deletions at positions 1,733~1,738 and 2,804~2,812, respectively, in the ORF1a gene. Phylogenetic analyses based on the whole gene sequence as well as S protein and ORF1a/1b protein sequences all showed that this strain was closely related to the Southeast Asia strain. When 7-day-old piglets were inoculated orally with the CHN/GX/1468B/2017 strain, they developed severe diarrhea, with a peak of fecal viral shedding at 4 days post-infection. Although no death or fever were observed, the CHN/GX/1468B/2017 strain produced a wide range of tissue tropism, with the main target being the intestine. Importantly, the VH:CD ratios of the jejunum and ileum in infected piglets were significantly lower than controls. These results indicate that CHN/GX/1468B/2017, isolated in China, is a novel PDCoV Southeast Asia-like strain with distinct genetic characteristics and pathogenicity. This finding enriches the international information on the genetic diversity of PDCoV.
Organic Oat Response to Variety, Seeding Rate, and Nutrient Source and Rate
Authors: Wilson Melissa L. , Evans Emily E. , Klossner Lee , Pagliari Paulo H.
Published: July 2021

Oat (Avena sativa L.) is an important crop for organic production systems in the upper Midwest, but limited information on optimal nutrient management and seeding rates is available. Oat varieties representing three maturity groups were evaluated during 2015 and 2016 in Lamberton, Minnesota on organically certified ground previously planted to alfalfa (Medicago sativa L.). Two oat seeding rates (110 and 145 kg ha−1), two nutrient sources (raw and composted beef manure), and four N application rates (0, 50, 100, and 150 kg ha−1) were studied. Plant population; number of tillers; grain yield; grain nutrient removal (primary and secondary macronutrients); and post-harvest soil nitrate, Bray P-1, and K in the top 0 to 15 cm layer were measured. Grain yield was 4.8, 4.0, and 3.8 kg ha−1 for late maturing Deon, early maturing Tack/Saber, and medium maturing Shelby, respectively. Yield was optimized at a nutrient application rate of 82.3 kg N ha−1 and decreased at higher rates. Grain N content was not related to yield, suggesting that the other nutrients in manure and compost may have been responsible for optimizing yield. High application rates resulted in increased residual soil test P and K levels, which could become problematic if not managed appropriately.
Monitoring of Emerging Water Stress Situations by Thermal and Vegetation Indices in Different Almond Cultivars
Authors: Gutiérrez-Gordillo Saray , de la Gala González-Santiago Javier , Trigo-Córdoba Emiliano , Rubio-Casal Alfredo Emilio , García-Tejero Iván Francisco , Egea Gregorio
Published: July 2021

In recent years, the area dedicated to modern irrigated almond plantations has increased significantly in Spain. However, the legal irrigation allocations are lower than the maximum water requirements of the crop in most cases. Therefore, almond growers are forced to implement regulated deficit irrigation strategies on their farms, applying water stress in certain resistant phenological periods and avoiding it in sensitive periods. Given the need to monitor the water status of the crop, especially in the most sensitive periods to water stress, the objective of this work was to evaluate the sensitivity of two UAV-based crop water status indicators to detect early water stress conditions in four almond cultivars. The field trial was conducted during 2020 in an experimental almond orchard, where two irrigation strategies were established: full irrigation (FI), which received 100% of irrigation requirements (IR), and regulated deficit irrigation (RDI), which received 70% of IR during the whole irrigation period except during the kernel-filling stage when received 40% IR. The UAV flights were performed on four selected dates of the irrigation season. The Crop Water Status Index (CWSI) and the Normalized Difference Vegetation Index (NDVI) were derived from thermal and multispectral images, respectively, and compared to classical water status indicators, i.e., stem water potential (Ψstem), stomatal conductance (gs), and photosynthetic rate (AN). Of the four flights performed, three corresponded to mild water stress conditions and a single flight was performed under moderate water stress conditions. Under mild water stress, CWSI was not able to capture the differences between FI and RDI trees that were observed with Ψstem. Under moderate stress conditions, CWSI was sensitive to the water deficit reached in the trees and showed significant differences among both irrigation treatments. No differences were observed in the CWSI and NVDI response to water stress among cultivars. Although NDVI and CWSI were sensitive to water stress, the low signal intensity observed in NDVI makes this index less robust than CWSI to monitor crop water stress. It can be concluded that UAV-based CWSI measurements are reliable to monitor almond water status, although for early (mild) levels of water stress, Ψstem seems to be the preferred option.
Controlled Grazing of Maize Residues Increased Carbon Sequestration in No-Tillage System: A Case of a Smallholder Farm in South Africa
Authors: Abdalla Khatab , Mutema Macdex , Chivenge Pauline , Chaplot Vincent
Published: July 2021

Despite the positive impact of no-tillage (NT) on soil organic carbon (SOC), its potential to reduce soil CO2 emission still needs enhancing for climate change mitigation. Combining NT with controlled-grazing of crop residues is known to increase nutrient cycling; however, the impacts on soil CO2 effluxes require further exploration. This study compared soil CO2 effluxes and SOC stocks from conventional tillage with free grazing (CTFG), NT with free grazing (NTFG), NT without grazing (NTNG), NT without crop residues (NTNR) and NT with controlled-grazing (NTCG), in South Africa. Soil CO2 effluxes were measured 1512 times over two years using LI-COR 6400XT, once to thrice a month. Baseline SOCs data were compared against values obtained at the end of the trial. Overall, NTCG decreased soil CO2 fluxes by 55 and 29% compared to CTFG and NTNR, respectively. NTCG increased SOCs by 3.5-fold compared to NTFG, the other treatments resulted in SOC depletion. The increase in SOCs under NTCG was attributed to high C input and also low soil temperature, which reduce the SOC mineralization rate. Combining NT with postharvest controlled-grazing showed high potential to increase SOCs, which would help to mitigate climate change. However, it was associated with topsoil compaction. Therefore, long-term assessment under different environmental, crop, and soil conditions is still required.
Impact of Long-Term Manure and Sewage Sludge Application to Soil as Organic Fertilizer on the Incidence of Pathogenic Microorganisms and Antibiotic Resistance Genes
Authors: Stiborova Hana , Kracmarova Martina , Vesela Tereza , Biesiekierska Marta , Cerny Jindrich , Balik Jiri , Demnerova Katerina
Published: July 2021

The reuse of stabilized (under thermophilic conditions) sewage sludge and manure on agricultural soils is a common practice. The aim of this study was to evaluate the risks associated with their repeated applications on the spread of pathogenic bacteria and antibiotic resistance genes (ARGs) that encode resistance to tetracycline (tetA and tetW), sulphonamide (sul1 and sul2), erythromycin (ermB), vancomycin (vanA) and integron genetic element (intI1). The trial fields has been regularly fertilized every 3rd year since 1996 with manure (MF; 330 kg N/ha) and sewage sludge (SF; 330 kg N/ha and SF3; 990 kg N/ha). Unfertilized soil (CF) served as a control. Samples were collected at different time points: (i) right before fertilization (which was also 3 years after the last fertilization), (ii) 5 months after fertilization, and (iii) 11 months after fertilization. The relative abundance of amplicon sequence variants (ASVs) assigned to potentially pathogenic bacteria was low (0.3% and 0.25% in sludge and manure, respectively), and no association with the application of these fertilizers was found. On the other hand, our data indicate that an increased relative abundance of the ARGs sul1 and tetW was significantly associated with these fertilizer applications, and sul1 was increased in all treatments regardless of the time. It is suggested that sul1 should be monitored in organically fertilized soils to prevent its spread and possible further accumulation in crops.
Performance and Stability of Different Monoecious Hemp Cultivars in a Multi-Environments Trial in North-Eastern Italy
Authors: Ferfuia Claudio , Zuliani Fabio , Danuso Francesco , Piani Barbara , Cattivello Costantino , Dorigo Gaia , Baldini Mario
Published: July 2021

The seed yield in hemp (Cannabis sativa L.) is strongly influenced, besides by genotype, by environment and the genotype x environment interaction, so establishing the fitness and stability of hemp cultivars in multiple environments is necessary. The purpose of this study was to investigate the performance and degree of stability and variance of seed yield, the main related traits, and the correlation among the traits in five hemp monoecious cultivars cultivated in six different environments. The environments resulted from the combination of four locations, two years, and two delayed sowings in a Mediterranean area of north-eastern Italy, and the stability index of the weighted average of absolute scores (WAAS) was used in order to identify the most productive and stable genotypes on the basis of their deviation from the average performance across environments. In this studied area, early varieties, such as Fedora and Felina, proved to be the best performing and stable for seed yield and both increased their yield in correspondence to delayed sowing times, opening up the possibility of cultivating hemp as a second crop. Among the climate parameters, high temperatures during the early grain filling period led to a progressive decrease in seed yield. For a dual-purpose crop, a good compromise could be a late monoecious cultivar (like Futura, in the present experiment), which, if sown early, could certainly provide notable biomass production and acceptable seed yield.
Amino Acids Supplementation for the Milk and Milk Protein Production of Dairy Cows
Authors: Kim Jung-Eun , Lee Hong-Gu
Published: July 2021

As the preference of consumers for casein products has increased, the protein content of milk from dairy cows is drawing more attention. Protein synthesis in the milk of dairy cows requires a proper supply of dietary protein. High protein supplementation may help to produce more milk protein, but residues in feces and urine cause environmental pollution and increase production costs. As such, previous studies have focused on protein supplements and amino acid (AA) supply. This review concerns AA nutrition for enhancing milk protein in dairy cows, and mainly focuses on three AAs: methionine, lysine, and histidine. AA supplementation for promoting protein synthesis is related to the mammalian target of rapamycin (mTOR) complex and its downstream pathways. Each AA has different stimulating effects on the mTOR translation initiation pathway, and thus manifests different milk protein yields. This review will expand our understanding of AA nutrition and the involved pathways in relation to the synthesis of milk protein in dairy cows.
Scorpion Venom Peptide Effects on Inhibiting Proliferation and Inducing Apoptosis in Canine Mammary Gland Tumor Cell Lines
Authors: Panja Kamonporn , Buranapraditkun Supranee , Roytrakul Sittiruk , Kovitvadhi Attawit , Lertwatcharasarakul Preeda , Nakagawa Takayuki , Limmanont Chunsumon , Jaroensong Tassanee
Published: July 2021

The most common neoplasms in intact female dogs are CMGTs. BmKn-2, an antimicrobial peptide, is derived from scorpion venom and has published anticancer effects in oral and colon human cancer cell lines. Thus, it is highly likely that BmKn-2 could inhibit CMGT cell lines which has not been previously reported. This study investigated the proliferation and apoptotic properties of BmKn-2 via Bax and Bcl-2 relative gene expression in two CMGT cell lines, metastatic (CHMp-5b) and non-metastatic (CHMp-13a). The results showed that BmKn-2 inhibited proliferation and induced apoptosis in the CMGT cell lines. The cell morphology clearly changed and increased apoptosis in a dose dependent of manner. The half maximum inhibitory concentration (IC50) was 30 µg/mL for CHMp-5b cell line and 54 µg/mL for CHMp-13a cell line. The induction of apoptosis was mediated through Bcl-2 and Bax expression after BmKn-2 treatment. In conclusion, BmKn-2 inhibited proliferation and induced apoptosis in both CHMp-5b and CHMp-13a cell lines via down-regulation of Bcl-2 and up-regulation of Bax relative mRNA expression. Therefore, BmKn-2 could be feasible as candidate treatment for CMGTs.
A Bi-Level Model for Detecting and Correcting Parameter Cyber-Attacks in Power System State Estimation
Authors: Aljohani Nader , Bretas Arturo
Published: July 2021

Power system state estimation is an important component of the status and healthiness of the underlying electric power grid real-time monitoring. However, such a component is prone to cyber-physical attacks. The majority of research in cyber-physical power systems security focuses on detecting measurements False-Data Injection attacks. While this is important, measurement model parameters are also a most important part of the state estimation process. Measurement model parameters though, also known as static-data, are not monitored in real-life applications. Measurement model solutions ultimately provide estimated states. A state-of-the-art model presents a two-step process towards simultaneous false-data injection security: detection and correction. Detection steps are χ2 statistical hypothesis test based, while correction steps consider the augmented state vector approach. In addition, the correction step uses an iterative solution of a relaxed non-linear model with no guarantee of optimal solution. This paper presents a linear programming method to detect and correct cyber-attacks in the measurement model parameters. The presented bi-level model integrates the detection and correction steps. Temporal and spatio characteristics of the power grid are used to provide an online detection and correction tool for attacks pertaining the parameters of the measurement model. The presented model is implemented on the IEEE 118 bus system. Comparative test results with the state-of-the-art model highlight improved accuracy. An easy-to-implement model, built on the classical weighted least squares solution, without hard-to-derive parameters, highlights potential aspects towards real-life applications.
KRDroid: Ransomware-Oriented Detector for Mobile Devices Based on Behaviors
Authors: Wang Senmiao , Qin Sujuan , Qin Jiawei , Zhang Hua , Tu Tengfei , Jin Zhengping , Guo Jing
Published: July 2021

Ransomware has become a serious threat on Android and new cases of ransomware are continuously growing. Most existing ransomware detectors use sensitive text or APIs to detect ransomware. Some goodware applications with the functionalities of locking screen and encrypting files have similar behaviors with ransomware. It is difficult for ransomware detectors to identity them. In this paper, we made detailed analyses of three kinds of active ransomware. We proposed a behavior-based ransomware detector on Android, called KRDroid. KRDroid deploys on servers or PCs, that is, ransomware cannot be activated and cause any loss during testing. Experiments showed that our ransomware-oriented detector can find 1809 of 1862 unseen ransomware. It can also distinguish goodware with similar ransom behaviors to ransomware with an accuracy of 97.5%.
Hierarchical Population Game Models of Coevolution in Multi-Criteria Optimization Problems under Uncertainty
Authors: Serov Vladimir A.
Published: July 2021

The article develops hierarchical population game models of co-evolutionary algorithms for solving the problem of multi-criteria optimization under uncertainty. The principles of vector minimax and vector minimax risk are used as the basic principles of optimality for the problem of multi-criteria optimization under uncertainty. The concept of equilibrium of a hierarchical population game with the right of the first move is defined. The necessary conditions are formulated under which the equilibrium solution of a hierarchical population game is a discrete approximation of the set of optimal solutions to the multi-criteria optimization problem under uncertainty.
Comprehensive Evaluation of the Visual Environment of a Railroad Station’s Platform, Focused on the User’s Psychology
Authors: Heo Jaeyoung , Kozaki Miki , Koga Takaaki , Hirate Kotaroh , Kim Hyun Bae
Published: July 2021

Through a comprehensive evaluation of the spaces of 25 railway stations, where power-saving operations are being conducted due to an earthquake, the effects of various components of the space on users’ psychology were reviewed. For the platforms of railway stations, which are divided into ‘island platforms’ and ‘side platforms’ the ‘physical quantity measurement’ and ‘impression evaluation’ were assessed. When a simple power-saving method, such as partial lighting up is adopted, it has been shown that there is a negative effect on the users, both physically and psychologically. In particular, in the case of outdoor platforms, there is a concern that glare and anxiety due to contrast may increase; therefore, it is necessary to utilize the reflective surfaces effectively. Floor illuminance is fundamental to lighting design. However, some areas cannot be evaluated by floor illuminance alone. The difference in the results of the impression evaluation in five areas with floor illuminance around 50 lx was widely distributed, and it was found that the shape and material of the space affected the results. If platform screen doors are installed, a lighting method that can evenly illuminate the interior of the space is necessary. By reviewing each factor that determines the visual impression, it was revealed that the lighting location and lighting method were significantly affected.
Computational Chemistry to Repurposing Drugs for the Control of COVID-19
Authors: Hassanzadeganroudsari Majid , Ahmadi Amir , Rashidi Niloufar , Hossain Md , Habib Amanda , Apostolopoulos Vasso
Published: July 2021

Thus far, in 2021, 219 countries with over 175 million people have been infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is a positive sense, single-stranded RNA virus, and is the causal agent for coronavirus disease (COVID-19). Due to the urgency of the situation, virtual screening as a computational modeling method offers a fast and effective modality of identifying drugs that may be effective against SARS-CoV-2. There has been an overwhelming abundance of molecular docking against SARS-CoV-2 in the last year. Due to the massive volume of computational studies, this systematic review has been created to evaluate and summarize the findings of existing studies. Herein, we report on computational articles of drugs which target, (1) viral protease, (2) Spike protein-ACE 2 interaction, (3) RNA-dependent RNA polymerase, and (4) other proteins and nonstructural proteins of SARS-CoV-2. Based on the studies presented, there are 55 identified natural or drug compounds with potential anti-viral activity. The next step is to show anti-viral activity in vitro and translation to determine effectiveness into human clinical trials.
Osteopontin in Cardiovascular Diseases
Authors: Shirakawa Kohsuke , Sano Motoaki
Published: July 2021

Unprecedented advances in secondary prevention have greatly improved the prognosis of cardiovascular diseases (CVDs); however, CVDs remain a leading cause of death globally. These findings suggest the need to reconsider cardiovascular risk and optimal medical therapy. Numerous studies have shown that inflammation, pro-thrombotic factors, and gene mutations are focused not only on cardiovascular residual risk but also as the next therapeutic target for CVDs. Furthermore, recent clinical trials, such as the Canakinumab Anti-inflammatory Thrombosis Outcomes Study trial, showed the possibility of anti-inflammatory therapy for patients with CVDs. Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions and is involved in a number of pathological states in CVDs. OPN has a two-faced phenotype that is dependent on the pathological state. Acute increases in OPN have protective roles, including wound healing, neovascularization, and amelioration of vascular calcification. By contrast, chronic increases in OPN predict poor prognosis of a major adverse cardiovascular event independent of conventional cardiovascular risk factors. Thus, OPN can be a therapeutic target for CVDs but is not clinically available. In this review, we discuss the role of OPN in the development of CVDs and its potential as a therapeutic target.
Dyslipidaemia in Type 1 Diabetes: Molecular Mechanisms and Therapeutic Opportunities
Authors: O’Brien Stephen T. , Neylon Orla M. , O’Brien Timothy
Published: July 2021

Cardiovascular disease (CVD) is the leading cause of death in Type 1 Diabetes (T1D). The molecular basis for atherosclerosis in T1D is heavily influenced by hyperglycaemia and its atherogenic effects on LDL. Ongoing research into the distinct pathophysiology of atherosclerosis in T1D offers exciting opportunities for novel approaches to calculate CVD risk in patients with T1D and to manage this risk appropriately. Currently, despite the increased risk of CVD in the T1D population, there are few tools available for estimating the risk of CVD in younger patients. This poses significant challenges for clinicians in selecting which patients might benefit from lipid-lowering therapies over the long term. The current best practice guidance for the management of dyslipidaemia in T1D is generally based on evidence from patients with T2D and the opinion of experts in the field. In this review article, we explore the unique pathophysiology of atherosclerosis in T1D, with a specific focus on hyperglycaemia-induced damage and atherogenic LDL modifications. We also discuss the current clinical situation of managing these patients across paediatric and adult populations, focusing on the difficulties posed by a lack of strong evidence and various barriers to treatment.
Emerging Evidence of the Functional Impact of the miR379/miR656 Cluster (C14MC) in Breast Cancer
Authors: McCarthy Elan C. , Dwyer Róisín M.
Published: July 2021

Many microRNAs exist in clusters that share comparable sequence homology and may target genes in a common pathway. The miR-379/miR-656 (C14MC) cluster is imprinted in the DLK1-Dio3 region of 14q32.3 and contains 42 miRNAs. It plays a functional role in numerous biological pathways including vascular remodeling and early development. With many C14MC miRNAs highlighted as potential tumor suppressors in a variety of cancers, the role of this cluster in breast cancer (BC) has garnered increased attention in recent years. This review focuses on C14MC in BC, providing an overview of the constituent miRNAs and addressing each in terms of functional impact, potential target genes/pathways, and, where relevant, biomarker capacity. Studies have revealed the regulation of key factors in disease progression and metastasis including tyrosine kinase pathways and factors critical to epithelial–mesenchymal transition (EMT). This has potentially important clinical implications, with EMT playing a critical role in BC metastasis and tyrosine kinase inhibitors (TKIs) in widespread use for the treatment of BC. While the majority of studies have reported tumor-suppressing roles for these miRNAs, some have highlighted their potential as oncomiRs. Understanding the collective contribution of miRNAs within C14MC to BC may support improved understanding of disease etiology and present novel approaches to targeted therapy.
Autonomous Vehicles and Vulnerable Road-Users—Important Considerations and Requirements Based on Crash Data from Two Countries
Authors: Morris Andrew Paul , Haworth Narelle , Filtness Ashleigh , Nguatem Daryl-Palma Asongu , Brown Laurie , Rakotonirainy Andry , Glaser Sebastien
Published: July 2021

(1) Background: Passenger vehicles equipped with advanced driver-assistance system (ADAS) functionalities are becoming more prevalent within vehicle fleets. However, the full effects of offering such systems, which may allow for drivers to become less than 100% engaged with the task of driving, may have detrimental impacts on other road-users, particularly vulnerable road-users, for a variety of reasons. (2) Crash data were analysed in two countries (Great Britain and Australia) to examine some challenging traffic scenarios that are prevalent in both countries and represent scenarios in which future connected and autonomous vehicles may be challenged in terms of safe manoeuvring. (3) Road intersections are currently very common locations for vulnerable road-user accidents; traffic flows and road-user behaviours at intersections can be unpredictable, with many vehicles behaving inconsistently (e.g., red-light running and failure to stop or give way), and many vulnerable road-users taking unforeseen risks. (4) Conclusions: The challenges of unpredictable vulnerable road-user behaviour at intersections (including road-users violating traffic or safe-crossing signals, or taking other risks) combined with the lack of knowledge of CAV responses to intersection rules, could be problematic. This could be further compounded by changes to nonverbal communication that currently exist between road-users, which could become more challenging once CAVs become more widespread.
The Role of Personal Values in Learning Approaches and Student Achievements
Authors: Gamage Kelum A. A. , Dehideniya D. M. S. C. P. K. , Ekanayake Sakunthala Y.
Published: July 2021

Personal values play a significant role when adopting learning approaches by individuals during their studies. Particularly in higher education, these values significantly influence the character that individuals play within their learning community and ultimately influence their academic achievements. The purpose of this paper is to investigate personal values in their choice of learning approaches and, subsequently, how it impacts one’s academic achievements. It also investigates the importance of developing an individual’s personal values as a part of their wider studies, while aligning these with graduate attributes and balancing them with knowledge and skills, to produce successful graduates in a society.
Claisened Hexafluoro Inhibits Metastatic Spreading of Amoeboid Melanoma Cells
Authors: Leo Angela , Pranzini Erica , Pietrovito Laura , Pardella Elisa , Parri Matteo , Cirri Paolo , Bruno Gennaro , Calvani Maura , Peppicelli Silvia , Torre Eugenio , Sasaki Maiko , Yang Lily , Zhu Lei , Chiarugi Paola , Raugei Giovanni , Arbiser Jack L. , Taddei Maria Letizia
Published: July 2021

Metastatic melanoma is characterized by poor prognosis and a low free-survival rate. Thanks to their high plasticity, melanoma cells are able to migrate exploiting different cell motility strategies, such as the rounded/amoeboid-type motility and the elongated/mesenchymal-type motility. In particular, the amoeboid motility strongly contributes to the dissemination of highly invasive melanoma cells and no treatment targeting this process is currently available for clinical application. Here, we tested Claisened Hexafluoro as a novel inhibitor of the amoeboid motility. Reported data demonstrate that Claisened Hexafluoro specifically inhibits melanoma cells moving through amoeboid motility by deregulating mitochondrial activity and activating the AMPK signaling. Moreover, Claisened Hexafluoro is able to interfere with the adhesion abilities and the stemness features of melanoma cells, thus decreasing the in vivo metastatic process. This evidence may contribute to pave the way for future possible therapeutic applications of Claisened Hexafluoro to counteract metastatic melanoma dissemination.
Radiation Pneumonitis in Thoracic Cancer Patients: Multi-Center Voxel-Based Analysis
Authors: Palma Giuseppe , Monti Serena , Pacelli Roberto , Liao Zhongxing , Deasy Joseph O. , Mohan Radhe , Cella Laura
Published: July 2021

This study investigates the dose–response patterns associated with radiation pneumonitis (RP) in patients treated for thoracic malignancies with different radiation modalities. To this end, voxel-based analysis (VBA) empowered by a novel strategy for the characterization of spatial properties of dose maps was applied. Data from 382 lung cancer and mediastinal lymphoma patients from three institutions treated with different radiation therapy (RT) techniques were analyzed. Each planning CT and biologically effective dose map (α/β = 3 Gy) was spatially normalized on a common anatomical reference. The VBA of local dose differences between patients with and without RP was performed and the clusters of voxels with dose differences that significantly correlated with RP at a p-level of 0.05 were generated accordingly. The robustness of VBA inference was evaluated by a novel characterization for spatial properties of dose maps based on probabilistic independent component analysis (PICA) and connectograms. This lays robust foundations to the obtained findings that the lower parts of the lungs and the heart play a prominent role in the development of RP. Connectograms showed that the dataset can support a radiobiological differentiation between the main heart and lung substructures.