bluuebunny/crossref_metadata_2025 huggingface dataset:
Turtles and tortoises of Syria: Diversity, distribution, and conservation
Authors: AIDEK AHMAD E. , SAAD ADIB , JABLONSKI DANIEL , ESTERBAUER HANS , FRITZ UWE
Published: September 2024

Syria is home to a wide range of ecosystems and landscapes that support a variety of animal species, including reptiles. Currently, Syria hosts nine species of chelonians (turtles and tortoises) from six different families, making its family-level diversity remarkable for the Mediterranean and the Middle East. We conducted a comprehensive review of existing literature, database information, and museum records, and incorporated new field data collected between 2019 and 2023 to document the distribution and conservation status of chelonians in Syria. As a result, we present an updated species list, accompanied by relevant information and occurrence maps for each turtle and tortoise species found in the country. Our investigation has yielded a total of 321 distribution records for Syrian chelonians (including nests of marine species), 105 of which are new. In addition, we verified 18 sites previously documented in the literature. Among the most frequently recorded species is Testudo graeca terrestris Forskål, 1775. In addition, for the first time, we have systematically evaluated the records of two marine turtle species that use Syrian coasts as nesting sites. This study is the most comprehensive and up-to-date source of information on the distribution and biogeography of chelonians in Syria, encompassing both historical and current geographic records. In addition, our data provide a zoogeographic overview and a substantial dataset of distribution information that can be used for subsequent analysis of macroecological patterns, distribution patterns, and conservation efforts related to this group of reptiles.
Resmetirom
Authors: Levien Terri L. , Baker Danial E.
Published: September 2024

Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy and Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are available online to subscribers. Monographs can be customized to meet the needs of a facility. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service, contact Wolters Kluwer customer service at 866-397-3433.
The Impact of Meaningful Vibrotactile Displays on User Preferences Across Age Groups in Automated Driving
Authors: Zhang Zhi , Lo Wei-Hsiang , Huang Gaojian
Published: September 2024

Automated vehicles may enhance the quality of life by empowering individuals and promoting independent mobility, especially for older adults. However, takeovers are still required occasionally. To ensure a safe transition during the takeover, meaningful tactile displays as takeover requests could be a good option to improve takeover efficiency. Previous studies have examined the effects of tactile takeover request more from an objective perspective, however, subjective evaluations that could reach larger and more diverse sample sizes have not been extensively conducted yet. Therefore, the goal of this study was to investigate drivers of different age groups (younger and older adults) on their preference of vibrotactile displays, varied in information formats (instructional and informative) and locations (seat back and seat pan), on a large population scale ( n = 353) through a national survey. The results indicated a preference for informative patterns over instructional patterns and displays on the seat back over the seat pan. Also, a higher level of perceived urgency was noted in older participants (age ≥ 65) compared with younger participants. These findings may inform the design of next-generation tactile interfaces in automated systems.
Relation between serum sclerostin and CTRP3 levels and bone mineral density in diabetic postmenopausal women
Authors: Ahmad Inass Hassan , Elhamed Gbr Sally Said Abd , Ali El Naggar Basma Mohamed Mohamed , Abdelwahab Marwa Khairy , El-saghier Entesar Omar Ahmad , Mohammed Doaa Sayed , Mohamed Marwa Abdelmonim , Mohamed Maha S. , Ali Abd El-Rahim Marwa Mohamed M. , Attar Shahinaz El
Published: September 2024

Background

Osteoporosis (OP) is a common finding in diabetic patients especially high-risk populations such as postmenopausal women. Sclerostin is a glycoprotein chiefly secreted by mature osteocytes and is considered a main regulator of bone formation. The C1q/TNF-Related Protein 3 (CTRP3) was found to be significantly associated with OP in postmenopausal women. The effect of type 2 diabetes mellitus (T2DM) on sclerostin and CTRP3 levels in postmenopausal women is rarely investigated. The present study aimed to assess the impact of T2DM on sclerostin and CTRP3 levels and their relation to OP in postmenopausal women.

Methods

The study included 60 postmenopausal women with T2DM and 60 age-matched postmenopausal non-diabetic women. Bone mineral density (BMD) was assessed using dual energy X-ray absorptiometry (DEXA). Serum levels of sclerostin and CTRP3 were assessed using enzyme-linked immunosorbent assay (ELISA) technique.

Results

Diabetic group expressed significantly higher serum levels of sclerostin when compared with non-diabetic group (110.0 ± 29.0 versus 51.5 ± 23.2 ng; p < 0.001). Oppositely, CTRP3 were significantly lower in the diabetic group (3.5 ± 3.5 versus 9.9 ± 3.7 ng/ml, p < 0.001). Multivariate logistic regression analysis identified HbA1c levels [OR (95% CI): 0.49 (0.26–0.93), p = 0.028], sclerotin levels [OR (95% CI): 1.06 (1.0-1.012), p = 0.041] and CTRP3 levels [OR (95%) CI: 1.64 (1.0-2.68), p = 0.047] as significant predictors of OP in diabetic patients.

Conclusions

Sclerostin and CTRP3 levels are involved in OP in postmenopausal diabetic patients.
Exploring the use of social network analysis methods in process improvement within healthcare organizations: a scoping review
Authors: Francis Troy , Davidson Morgan , Senese Laura , Jeffs Lianne , Yousefi-Nooraie Reza , Ouimet Mathieu , Rac Valeria , Trbovich Patricia
Published: September 2024

Background

Communication breakdowns among healthcare providers have been identified as a significant cause of preventable adverse events, including harm to patients. A large proportion of studies investigating communication in healthcare organizations lack the necessary understanding of social networks to make meaningful improvements. Process Improvement in healthcare (systematic approach of identifying, analyzing, and enhancing workflows) is needed to improve quality and patient safety. This review aimed to characterize the use of SNA methods in Process Improvement within healthcare organizations.

Methods

Relevant studies were identified through a systematic search of seven databases from inception - October 2022. No limits were placed on study design or language. The reviewers independently charted data from eligible full-text studies using a standardized data abstraction form and resolved discrepancies by consensus. The abstracted information was synthesized quantitatively and narratively.

Results

Upon full-text review, 38 unique articles were included. Most studies were published between 2015 and 2021 (26, 68%). Studies focused primarily on physicians and nursing staff. The majority of identified studies were descriptive and cross-sectional, with 5 studies using longitudinal experimental study designs. SNA studies in healthcare focusing on process improvement spanned three themes: Organizational structure (e.g., hierarchical structures, professional boundaries, geographical dispersion, technology limitations that impact communication and collaboration), team performance (e.g., communication patterns and information flow among providers., and influential actors (e.g., key individuals or roles within healthcare teams who serve as central connectors or influencers in communication and decision-making processes).

Conclusions

SNA methods can characterize Process Improvement through mapping, quantifying, and visualizing social relations, revealing inefficiencies, which can then be targeted to develop interventions to enhance communication, foster collaboration, and improve patient safety.
Pre-natal and early life lead exposure and childhood inhibitory control: an item response theory approach to improve measurement precision of inhibitory control
Authors: Liu Shelley H. , Chen Yitong , Bellinger David , de Water Erik , Horton Megan , Téllez-Rojo Martha M. , Wright Robert
Published: September 2024

Background

Neurodevelopmental performance tasks are often separately analyzed, even when they tap into a similar construct. This may yield mixed findings for associations of an exposure-neurobehavioral outcome. We develop an item response theory (IRT) approach to integrate multiple task variables together to improve measurement precision of the underlying construct. We apply this approach to create an integrative measure of childhood inhibitory control, and study impacts of pre/post-natal lead exposure.

Methods

Using data from a prospective cohort based in Mexico (N = 533), we created an inhibitory control scale that integrates accuracy and reaction time information from four inhibitory control tasks (Go/NoGo Letter, Go/NoGo Neutral, Go/NoGo Happy, Delis-Kaplan Executive Function System (D-KEFS) Color-Word Interference Test, Condition 3). Using a generalized partial credit item response theory model, we estimated an inhibitory control index for each participant. We then assessed adjusted associations between umbilical cord blood and 4-year lead and childhood inhibitory control. We developed a resampling approach to incorporate error estimates from the inhibitory control variable to confirm the consistency of the lead-inhibitory control associations. We modeled time-varying associations of lead with each inhibitory control measure separately.

Results

Participants had a median age of 9 years; 51.4% were males. Umbilical cord blood [-0.06 (95% CI: -0.11, -0.01)] and 4-year lead [-0.07 (95% CI: -0.12, -0.02)] were associated with inhibitory control index at 8–10 years. A resampling approach confirmed that 4-year lead was consistently associated with childhood inhibitory control index. Umbilical cord blood and 4-year lead were each associated with 3 out of 8 measures in separate models.

Conclusion

This is the first application of IRT in environmental epidemiology to create a latent variable for inhibitory control that integrates accuracy and reaction time information from multiple, related tasks. This framework can be applied to other correlated neurobehavioral assessments or other phenotype data.
Universal screening of colorectal tumors for lynch syndrome: a survey of patient experiences and opinions
Authors: Petterson Alexander T. , Garbarini Jennifer , Baker Maria J.
Published: September 2024

Background

Lynch syndrome represents the most common hereditary cause of both colorectal and endometrial cancer. It is caused by defects in mismatch repair genes, as well as EPCAM. Universal screening of colon tumors for Lynch syndrome via microsatellite instability (MSI) and/or immunohistochemistry (IHC) can identify patients and families at risk to develop further cancers and potentially impact surveillance and treatment options. The approach to implementation of universal screening, taking ethical considerations into account, is critical to its effectiveness, with patient perspectives providing valuable insight.

Methods

Patients whose colon tumors underwent universal screening at Penn State Hershey Medical Center over a period of 2.5 years were mailed a survey on universal screening in 2017. Along with the survey, they received a recruitment letter and a summary explanation of research. The survey included both multiple choice and free-response questions that covered topics including respondent knowledge of Lynch syndrome, attitudes toward universal screening and experiences with the screening protocol as implemented.

Results

Sixty-six of 297 possible patients (22.2%) responded to the survey, including 13 whose screening results raised concern for Lynch syndrome. 75.8% of respondents supported universal tumor screening without informed consent. 92.4% preferred receiving screening results regardless of outcome. Respondents described benefits to screening for themselves and their families.

Conclusions

While broadly supporting universal tumor screening without informed consent, respondents also wanted more information shared about the screening policy, as well as their results. These patient preferences should be one of many factors considered when implementing universal screening and can also inform practices regarding both tumor profiling and universal genetic testing, which is becoming more prevalent.
Morphological description and genetic analysis of a new black fly species (Diptera: Simuliidae) in the subgenus Asiosimulium from central Thailand
Authors: Srisuka Wichai , Takaoka Hiroyuki , Taai Kritsana , Maleewong Wanchai , Aupalee Kittipat , Saeung Atiporn
Published: September 2024

Background

Black flies are among the most medically and veterinary important insects, as adult females of certain species are the sole vector of Onchocerca volvulus. Here, a new black fly species belonging to the subgenus Asiosimulium Takaoka & Choochote, 2005, is described and formally named as Simulium (Asiosimulium) kittipati sp. nov.

Methods

Pupae and larvae of black flies were collected from available substrates in the stream from central Thailand. Pupae were individually separated in plastic tubes and maintained until adult flies emerged. The emerged adult flies associated with their pupal exuviae and cocoon as well as mature larvae preserved in 85% ethanol were used to describe the new species based on an integrated approach of morphological examination and molecular analysis of the COI gene.

Results

The new species is characterized in the female by the medium-long sensory vesicle with a medium-sized opening apically, scutum with three faint longitudinal vittae, and the ellipsoidal spermatheca; in the male by the number of upper-eye (large) facets in 20 vertical columns and 21 horizontal rows, hind basitarsus slender, nearly parallel-sided, and median sclerite much wider and upturned apically; in the pupa by the head and thoracic integument densely covered with tiny tubercles, and the pupal gill of arborescent type with 28–30 filaments; and in the larva by the postgenal cleft deep, nearly reaching the posterior margin of the hypostoma, and dark pigmented sheath of the subesophageal ganglion. The DNA barcode successfully differentiated the new species from its congeners with an interspecific genetic divergence of 1.74–18.72%, confirming the morphological identification that the species is a new member of the subgenus Asiosimulium. Phylogenetic analyses also indicated that the new species is genetically closely related to Simulium phurueaense Tangkawanit, Wongpakam & Pramual, 2018, further supporting its morphological classification.

Conclusions

This is the ninth species assigned to the subgenus Asiosimulium within the genus Simulium Latreille, 1802. Taxonomic notes and identification keys are given to distinguish this new species from the eight known species members in its same subgenus. Additionally, a distribution map of all species members in this subgenus occurring in Thailand and other countries is provided.

Graphical abstract
A novel PDHK inhibitor restored cognitive dysfunction and limited neurodegeneration without affecting amyloid pathology in 5xFAD mouse, a model of Alzheimer’s disease
Authors: Sakimura Katsuya , Kawai Takashi , Nashida Reiko , Ishida Yuji , Harada Kana , Suzuki Takashi , Okuma Chihiro , Cole Gregory M.
Published: September 2024

Background

Alzheimer’s disease (AD) is the most common form of dementia. Although drugs focusing on reducing amyloid β slow progression, they fail to improve cognitive function. Deficits in glucose metabolism are reflected in FDG-PET and parallel the neurodegeneration and synaptic marker loss closely preceding cognitive decline, but the role of metabolic deficits as a cause or consequence of neurodegeneration is unclear. Pyruvate dehydrogenase (PDH) is lost in AD and an important enzyme connecting glycolysis and the tricarboxylic acid (TCA) cycle by converting pyruvate into acetyl-CoA. It is negatively regulated by pyruvate dehydrogenase kinase (PDHK) through phosphorylation.

Methods

In the present study, we assessed the in vitro/ in vivo pharmacological profile of the novel PDHK inhibitor that we discovered, Compound A. We also assessed the effects of Compound A on AD-related phenotypes including neuron loss and cognitive impairment using 5xFAD model mice.

Results

Compound A inhibited human PDHK1, 2 and 3 but had no inhibitory activity on PDHK4. In primary neurons, Compound A enhanced pyruvate and lactate utilization, but did not change glucose levels. In contrast, in primary astrocytes, Compound A enhanced pyruvate and glucose utilization and enhanced lactate production. In an efficacy study using 5xFAD mice, Compound A ameliorated the cognitive dysfunction in the novel object recognition test and Morris water maze. Moreover, Compound A prevented neuron loss in the hippocampus and cerebral cortex of 5xFAD without affecting amyloid β deposits.

Conclusions

These results suggest ameliorating metabolic deficits by activating PDH by Compound A can limit neurodegeneration and is a promising therapeutic strategy for treating AD.
The water–energy–food–ecosystem nexus in North Africa dryland farming: a multi-criteria analysis of climate-resilient innovations in Morocco
Authors: Kertolli Emirjona , Prosperi Paolo , Harbouze Rachid , Moussadek Rachid , Echchgadda Ghizlane , Belhouchette Hatem
Published: September 2024

Smallholder farmers, who mostly engage in low-value agriculture in the drylands of Northern Africa, were the first to have felt the effects of climate change, with threats to their livelihoods and food security. The increasing costs of agricultural production, poor water and energy infrastructure, loss of agricultural land due to urban expansion, fragmented resource management, and unsustainable management practices all contribute to this vulnerability to climate change. This highlights the urgent need for innovative practices in farming systems. Within the framework of the water–energy–food–ecosystem nexus, this paper explores innovative practices in dryland farming systems, by assessing their impact on water, energy, food, and ecosystem through stakeholder perception. In this work, we aim to present a systems approach for assessing the resilience of the water–energy–food–ecosystem nexus in arid and semiarid regions. By using a multi-criteria analysis (MCA) approach, the study—which focuses on the Fès–Meknès region in Morocco—involves local actors to help researchers identify the key variables in order to assist farmers in their adaptation to climate change. The findings revealed different priorities between farmers and other stakeholders regarding the adoption of agricultural innovations. Farmers prioritize innovations that guarantee higher profitability and more market opportunities, such as integrating olive trees with cereal crops, by highlighting the importance of sustainable income sources. Meanwhile, stakeholders, such as researchers, engineers, government officials, and agribusiness entrepreneurs, prioritize innovations that emphasize high water use efficiency, which is crucial for the resilience of dryland farming areas: for instance, rainwater harvesting or the use of drought-resistant crop varieties that directly address the need for water conservation. But in doing so they are overlooking broader aspects within the water–energy–food–ecosystem nexus.
A rare case report of urogenital anomaly in a teenage girl: Herlyn–Werner–Wunderlich syndrome/OHVIRA syndrome (Obstructed Hemivagina and Ipsilateral Renal Anomaly)
Authors: Joel Govardhana Das , Basetti Bhavya , Mallula Balaji Varaprasad
Published: September 2024

Background

Herlyn–Werner–Wunderlich syndrome also known as OHVIRA syndrome is a rare complex congenital developmental anomaly characterized by the triad of uterine didelphys, obstructed hemivagina causing hematometrocolpos and ipsilateral renal anomaly.

Case presentation

Here we report a case of a 14-year-old girl who presented with acute onset lower abdominal pain. Ultrasound and magnetic resonance imaging showed uterus didelphys, hematometrocolpos, obstructed hemivagina and right renal agenesis. Patient underwent hematocolpos drainage.

Conclusions

OHVIRA syndrome is an uncommon congenital anomaly. Imaging plays a major role in diagnosis. Surgery is the treatment of choice to resect the septum and relieve the obstruction. An early correct diagnosis is the goal to relieve the symptoms and prevent complications, caused by retrograde menstruation which may result in endometriosis and, also, preserve sexual and conception abilities.
Spinal arachnoid web: a systematic review of a rare entity, with two illustrative case reports
Authors: Naggar Amine , El Ouali Ibtissam , Aidi Saadia , Melhaoui Adyl , Ech-cherif el Kettani Najwa , Fikri Meriem , Jiddane Mohamed , Touarsa Firdaous
Published: September 2024

Background

Spinal arachnoid web (AW) is a very rare entity, with a limited number of cases documented in the literature. Our manuscript represented a comprehensive general review, encompassing various aspects of the subject matter without focusing on any single element. The objective of this systematic review was to describe and analyze reported cases of surgically proven spinal arachnoid webs (AWs) to elucidate their imaging and clinical features, pathophysiology, and optimal management strategies, and to determine the total number of documented cases in the literature. Patterns and commonalities across reported cases were identified to provide a clearer framework for diagnosing and treating this elusive condition. A search of Web of Science, PubMed, and Scopus, respecting PRISMA guidelines, was conducted to include reported cases of surgically proven spinal AW. Our surgically proven case was included as well.

Main body of the abstract

The search yielded 196 cases of surgically confirmed spinal AWs in the literature. Adding our case, the total is 197. They are seen commonly in middle-aged patients, slightly more prevalent in males, and often without an evident cause. Sensation disturbances were the most frequently found clinical signs, followed by gait difficulties, weakness, and pain. Symptoms were predominantly located in the lower limbs and trunk. On imaging, an indentation to the rear aspect of the spinal cord was most frequently found at the mid-thorax followed by the upper thorax, often associated with a syrinx or a hyperintense T2 cord signal, usually extending rostrally. Excision was the most efficient treatment.

Short conclusion

The assessment found that AW cases are rare in the literature, indicating the disease's scarcity. It manifests insidiously, with the shortest latency reported being 2 weeks. Upper limb symptoms occur in a quarter of cases regardless of the AW's thoracic location, likely due to rostral syrinx and cerebrospinal fluid flow disturbances. Most pathology results revealed fibrous connective tissue, similar to findings in arachnoid cysts, suggesting that AW may result from a ruptured arachnoid cyst or its precursor. Using 3D SPACE STIR and CISS MRI sequences is recommended to visualize the arachnoid band directly.
Phase I/Ib Trial of Inavolisib Plus Palbociclib and Endocrine Therapy for
PIK3CA
-Mutated, Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Advanced or Metastatic Breast Cancer
Authors: Jhaveri Komal L. , Accordino Melissa K. , Bedard Philippe L. , Cervantes Andrés , Gambardella Valentina , Hamilton Erika , Italiano Antoine , Kalinsky Kevin , Krop Ian E. , Oliveira Mafalda , Schmid Peter , Saura Cristina , Turner Nicholas C. , Varga Andrea , Cheeti Sravanthi , Hilz Stephanie , Hutchinson Katherine E. , Jin Yanling , Royer-Joo Stephanie , Peters Ubong , Shankar Noopur , Schutzman Jennifer L. , Juric Dejan
Published: September 2024

PURPOSE

To investigate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of inavolisib, a potent and selective small-molecule inhibitor of p110α that promotes the degradation of mutated p110α, in combination with palbociclib and endocrine therapy (ET), in a phase I/Ib study in patients with
PIK3CA
-mutated, hormone receptor–positive/human epidermal growth factor receptor 2–negative locally advanced/metastatic breast cancer (ClinicalTrials.gov identifier:
NCT03006172
).

METHODS

Women ≥18 years of age received inavolisib, palbociclib, and letrozole (Inavo + Palbo + Letro arm) or fulvestrant (Inavo + Palbo + Fulv arm) until unacceptable toxicity or disease progression. The primary objective was to evaluate safety or tolerability.

RESULTS

Fifty-three patients were included, 33 in the Inavo + Palbo + Letro arm and 20 in the Inavo + Palbo + Fulv arm. Median duration of inavolisib treatment was 15.7 and 20.8 months (cutoff: March 27, 2023), respectively. Treatment-related adverse events (TRAEs) occurred in all patients; the most frequent were stomatitis, hyperglycemia, and diarrhea; grade ≥3 any TRAE rates were 87.9% and 85.0%; 6.1% and 10.0% discontinued any treatment due to TRAEs in the Inavo + Palbo + Letro and Inavo + Palbo + Fulv arms, respectively. No PK drug–drug interactions (DDIs) were observed among the study treatments when administered. Confirmed objective response rates were 52.0% and 40.0% in patients with measurable disease, and median progression-free survival was 23.3 and 35.0 months in the Inavo + Palbo + Letro and Inavo + Palbo + Fulv arms, respectively. Available paired pre- and on-treatment tumor tissue and circulating tumor DNA analyses confirmed the effects of study treatment on pharmacodynamic and pathophysiologic biomarkers of response.

CONCLUSION

Inavolisib plus palbociclib and ET demonstrated a manageable safety profile, lack of DDIs, and promising preliminary antitumor activity.
Effects of Atrial Fibrillation Screening According to Thyroid Function: Post Hoc Analysis of the Randomized LOOP Study
Authors: Spona Daniel Camillo , Frodi Diana My , Xing Lucas Yixi , Kongebro Emilie Katrine , Haugan Ketil Jørgen , Graff Claus , Højberg Søren , Krieger Derk , Brandes Axel , Køber Lars , Olesen Morten S , Andersen Andreas , Hædersdal Sofie , Frikke-Schmidt Ruth , Svendsen Jesper Hastrup , Diederichsen Søren Zöga
Published: September 2024

Context

Subclinical thyroid dysfunction is a marker for atrial fibrillation (AF) and stroke risk.

Objective

This study explored the effects of AF screening according to thyroid-stimulating hormone (TSH) levels.

Methods

An AF screening trial (the LOOP study) was analyzed post hoc according to baseline TSH. The primary outcome was stroke or systemic embolism (SE). Secondary outcomes included major bleeding, all-cause death, and the combination of stroke, SE, and cardiovascular death.

Results

TSH measurements were available in 6003 of 6004 trial participants, 1500 randomized to implantable loop recorder (ILR) screening for AF and anticoagulation upon detection vs 4503 to usual care; mean age was 74.7 ± 4.1 years and 2836 (47%) were women. AF detection was approximately triple for ILR vs usual care across TSH tertiles (adjusted P interaction = 0.44). In the first tertile, screening was associated with decreased risk of the primary outcome (hazard ratio [HR] 0.52, 95% CI 0.30-0.90; P = .02) and stroke, SE, or cardiovascular death (HR 0.54, 95% CI 0.34-0.84; P = .006) compared with usual care, while no effect was observed among participants with higher TSH (adjusted P interaction .03 and .01, respectively). There was no effect on other outcomes. Analyses of continuous TSH or excluding those with abnormal TSH or thyroid medication showed similar results.

Conclusion

AF screening and subsequent treatment was associated with decreased stroke risk among participants with low TSH, though the yield of screening was similar across TSH levels. TSH may be useful as a marker to indicate benefit from AF screening vs overdiagnosis and overtreatment. These findings should be considered exploratory and warrant further study.
Impaired 11β-HSD1 Activity in a Male Patient With Cushing Disease Resulting in Lack of the Full Cushingoid Phenotype
Authors: Weber Robert J , Kawaja Christopher , Wallerstein Robert , Kunwar Sandeep M , Liu Chienying
Published: September 2024

We present a patient who had surgically confirmed CD but without the full cushingoid phenotype despite markedly elevated cortisol. Nonpathologic causes of elevated ACTH and cortisol were eliminated as were pathogenic variants in the glucocorticoid receptor gene. Further studies of urine metabolites, cortisol half-life, and the ratios of cortisone to cortisol conversion revealed impaired 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity. There have only been 2 prior reports of impaired 11β-HSD1 resulting in lack of classic cushingoid features in the past 2 decades. Our patient's presentation and previous reports demonstrate the key role of 11β-HSD1 in modulating intracellular cortisol concentration, therefore shielding the peripheral tissues from the effects of excess cortisol. When patients present with markedly elevated cortisol but without classic cushingoid features, impaired 11β-HSD1 should be considered in the differential diagnosis.
Diagnosing Primary Hyperparathyroidism in Pregnancy: A Case of Altered Parathyroid Hormone Degradation in Pregnancy
Authors: Luong Dianna , Hawke Kate , De Waal Elzahn , Duke Madeline , Wolski Penny
Published: September 2024

Diagnosing primary hyperparathyroidism in pregnancy is difficult due to pregnancy-related changes in parathyroid hormone (PTH); calcium; 1,25 vitamin D; and renal calcium excretion. Parathyroid hormone–related peptide (PTHrP) produced by the placenta adds additional complexity. Our case is the first to demonstrate an increased rate of PTH degradation within a pregnant individual who returned unexpectedly low PTH levels. We describe a 27-year-old female patient who presented at 25 weeks gestation with pancreatitis and hypercalcemia. Primary hyperparathyroidism was suspected but variable PTH results led to uncertainty and an assay error was considered. PTH samples were collected in both serum-separating tubes (SST) and EDTA tubes and compared to controls (5 nonpregnant and 5 pregnant individuals). Samples were retested every 2 hours for a period of 10 hours. A rapid decline in the measured PTH was noted in the index case, an observation which differed from controls. We postulated that internal and/or external factors influenced the PTH measurement obtained from our patient. From our observations, rapid PTH degradation in pregnancy, and individual variation in PTH stability and laboratory processes, can influence PTH results and impact on interpreting hypercalcemia in pregnancy.
Nonsteroidal Anti-Inflammatory Drugs Do Not Affect the Bone Metabolic Response to Exercise
Authors: STAAB JEFFERY S. , SCZUROSKI CARA E. , GWIN JESS A. , GEDDIS ALYSSA V. , HUGHES JULIE M. , ROBERTS BRANDON M.
Published: September 2024

Purpose

Nonsteroidal anti-inflammatory drugs (NSAID) are associated with increased stress fracture risk, potentially due to inhibiting the adaptive bone formation responses to exercise. This study investigated if a single, maximal dose of three different NSAID alters bone formation biomarker response to strenuous exercise.

Methods

In a randomized, counterbalanced order, 12 participants (10 male, 2 female), performed four bouts of plyometric jumps, each separated by at least 1 wk. Two hours before exercise, participants consumed either placebo or NSAID: ibuprofen (800 mg), celecoxib (200 mg), flurbiprofen (100 mg). Blood was collected before (PRE), and at 0, 15, 60, 120, and 240 min postexercise. Parathyroid hormone, ionized calcium, procollagen type 1 N-terminal propeptide, bone alkaline phosphatase, osteocalcin, C-terminal telopeptide of type 1 collagen, tartrate-resistant acid phosphatase, and sclerostin were measured. Prostaglandin E2 metabolite and creatinine were measured in urine. Data were analyzed using repeated-measures ANOVA and area under the curve analysis. Data are mean ± SD.

Results

There was an exercise effect for procollagen type 1 N-terminal propeptide, bone alkaline phosphatase, osteocalcin, C-terminal telopeptide of type 1 collagen, tartrate-resistant acid phosphatase, sclerostin, osteoprotegerin, parathyroid hormone, and ionized calcium (all P < 0.05), but no NSAID treatment effect for any biomarker (all P > 0.05). Area under the curve analyses were not different for any biomarker (P > 0.05). Prostaglandin E2 metabolite was higher during the placebo trial (322 ± 153 pg·mg−1 creatinine, P < 0.05) compared with ibuprofen (135 ± 83 pg·mg−1), celecoxib (202 ± 107 pg·mg−1), and flurbiprofen (159 ± 74 pg·mg−1).

Conclusions

Plyometric exercise induced changes in bone metabolism, but the responses were unaltered by consuming NSAID 2 h before exercise.
Η Αχειροποίητος Θεσσαλονίκης στο πλαίσιο της πρωτοβυζαντινής εκκλησιαστικής αρχιτεκτονικής
Authors: ΡΑΠΤΗΣ (Konstantinos Th. RAPTIS) Κωνσταντίνος Θ.
Published: September 2024

Βάσει της αρχιτεκτονικής ανάλυσης του ναού της Αχειροποιήτου στη Θεσσαλονίκη, που κατέστη δυνατή στο πλαίσιο του πρόσφατου έργου στερέωσης και αποκατάστασης του μνημείου, η παρούσα μελέτη ανιχνεύει τα κατάλοιπα της πρώτης oικοδομικής φάσης του παλίμψηστου κτηρίου, εξετάζει την αρχιτεκτονική μορφή της πρωτοβυζαντινής βασιλικής, η οποία φαίνεται ότι ανεγέρθηκε χωρίς υπερώα, κατά το πρότυπο των χριστιανικών βασιλικών της λατινικής Δύσης, και υπό το φως νέων στοιχείων αναθεωρεί τη χρονολόγηση της ίδρυσής της
Τέμπλα με δυτικά στοιχεία στα Βάτικα της Λακωνίας
Authors: ΑΣΛΑΝΙΔΗΣ (Klimis ASLANIDIS) Κλήμης
Published: September 2024

Σε τέσσερεις υστεροβυζαντινούς ναούς στα Βάτικα της Λακωνίας διατηρούνται κτιστά τέμπλα με λαξευτά στοιχεία που υιοθετούν μορφές της αρχιτεκτονικής του Δυτικού Μεσαίωνα. Η ασυνήθιστη μορφή τους θα πρέπει να αποδοθεί κυρίως στον αυτοσχεδιασμό ενός τοπικού συνεργείου. Τα τέμπλα χρονολογούνται πιθανώς στο πρώτο μισό του 15ου αιώνα ή λίγο αργότερα. Ορισμένες λεπτομέρειές τους παρουσιάζουν ομοιότητες με λαξευτά στοιχεία υστεροβυζαντινών ναών της περιοχής
Αναζητώντας τον ιδρυτή της μονής Δαφνίου
Authors: ΠΑΝΑΓΙΩΤΙΔΗ - ΚΕΣΙΣΟΓΛΟΥ (Maria PANAYOTIDI-KESISOGLOU) Μαρία
Published: September 2024

Στη μελέτη αυτή γίνεται προσπάθεια να συγκεντρωθούν στοιχεία σχετικά με την παντελώς άγνωστη προσωπικότητα του δωρητή του καθολικού της Κοίμησης της Θεοτόκου, στο Δαφνί. Με την εξέταση της ποιότητας και του νοηματικού περιεχομένου της ψηφιδωτής διακόσμησης αναζητούνται στοιχεία σχετικά με την προσωπικότητα του άγνωστου δωρητή. Ο Γρηγόριος Καματηρός χρημάτισε πραίτωρ του Θέματος Ελλάδος και Πελοποννήσου, όπως είναι γνωστό από μολυβδόβουλλα του 11ου/12ου αιώνα. Ο αξιωματούχος αυτός, λόγιος, με υψηλή θεολογική κατάρτιση και μεγάλο πλούτο, που απέκτησε ως φοροσυλλέκτης, γραμματέας του Αλεξίου Α΄ το 1094, ο οποίος συνδέθηκε εξ αγχιστείας με την οικογένεια των Δουκών και έφθασε στο υψηλό αξίωμα του λογοθέτη των σεκρέτων, έχει μεγάλη πιθανότητα να θεωρηθεί ο κτήτωρ της μονής Δαφνίου. Φαίνεται δε ότι ίδρυσε το μοναστήρι σε κτήματα της οικογένειάς του στην Αττική
Οι πρώτες φάσεις διακόσμησης του ναού της Μεταμορφώσεως του Σωτήρος στο Χρύσοβο Ναυπακτίας (αρχές του 14ου αιώνα και π. 1500)
Authors: ΧΟΥΛΙΑΡΑΣ (Ioannis P. CHOULIARAS) Ιωάννης Π.
Published: September 2024

Η αρχική διακόσμηση του ναού της Μεταμορφώσεως του Σωτήρος στο Χρύσοβο, από την οποία σώζεται ο άγιος Ιωάννης ο Πρόδρομος, τοποθετείται πιθανώς στις αρχές του 14ου αιώνα. Η δεύτερη και πιο εκτεταμένη φάση, η οποία χρονολογείται γύρω στο 1500, είναι έργο ενός αξιόλογου ζωγράφου εικόνων, γνήσιου εκφραστή της κρητικής τέχνης του 15ου αιώνα, με τους επώνυμους καλλιτέχνες της οποίας συγκρίνεται επάξια. Η ζωγραφική του θα μπορούσε να θεωρηθεί ο συνεκτικός κρίκος μεταξύ του Ξένου Διγενή και του Θεοφάνη του Κρητός.
Μια απεικόνιση τέμπλου και η παρουσία των Κρητικών στη μονή του Αρχαγγέλου Μιχαήλ του Ρουκουνιώτη στη Σύμη τον 17ο αιώνα
Authors: ΜΠΙΘΑ ( Ioanna BITHA) Ιωάννα
Published: September 2024

Στο παλαιό καθολικό της μονής του Αρχαγγέλου Μιχαήλ του Ρουκουνιώτη στη Σύμη διατηρείται απεικόνιση τέμπλου σε φυσικό μέγεθος σε συνέχεια του ξυλόγλυπτου τέμπλου. Πρόκειται για έναν ενδιαφέροντα συνδυασμό, όχι μόνον γιατί δεν συναντάται αλλού, αλλά γιατί αποτελεί την ευφάνταστη λύση της ανάγκης να αποκτήσει η μονή ένα τέμπλο άξιο της ιστορίας της, ικανοποιώντας ίσως ευρύτερες θεολογικές αναζητήσεις της εποχής. Το εγχείρημα εικάζεται ότι ανέλαβε να εκπληρώσει στις αρχές του 17ου αιώνα συνεργείο κρητικών ζωγράφων, ενδεχόμενα με επικεφαλής τον Στυλιανό Γενίτη και τον Αντώνιο Μπόνη, έργα των οποίων βρίσκονται στη μονή.
Jewellery, items of private devotion and dress accessories from the Epano Kastro of Andros (13th-16th centuries)
Authors: ΜΠΑΡΜΠΑΡΙΤΣΑ (Eleni BARBARITSA) Ελένη
Published: September 2024

Epano Kastro is located in the southeast of the island of Andros and was built by the Venetian sovereigns after 1205. During the period 2004-2010 the National and Kapodistrian University of Athens conducted excavations at strategic parts of the castle. Rings, items of private devotion and dress accessories from the excavation at Epano Kastro, most of which date back to the Venetian occupation (1205- 1566), suggest the existence of a provincial society that was aware of the main dress codes of the Late Middle Ages.
Από τον decumanus maximus της Ύστερης Αρχαιότητας στη μεσοβυζαντινή Μέση ή Λεωφόρο της Θεσσαλονίκης. Η συμβολή των πρόσφατων ανασκαφών
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (ΧΑΕ)
Published: September 2024

Από τον decumanus maximus της Ύστερης Αρχαιότητας στη μεσοβυζαντινή Μέση ή Λεωφόρο της Θεσσαλονίκης. Η συμβολή των πρόσφατων ανασκαφώνΒιβλιογραφία για τις ανασκαφές και τα ευρήματα στους σταθμούς Βενιζέλου και Αγίας Σοφίας επί της Εγνατίας οδού Θεσσαλονίκης
Δύο λανθάνουσες επιγραφές από την Άνδρο και η δράση των δωρητών στο νησί κατά τη μέση βυζαντινή περίοδο
Authors: ΠΑΛΛΗΣ (Georgios PALLIS) Γιώργος
Published: September 2024

Το νησί της Άνδρου ξεχωρίζει ανάμεσα στις Κυκλάδες για την υψηλής ποιότητας αρχιτεκτονική και καλλιτεχνική παραγωγή που έχει να επιδείξει κατά τη μέση βυζαντινή περίοδο. Δύο γνωστές από παλαιά αλλά μη ακριβώς χρονολογημένες επιγραφές, οι οποίες αναφέρονται σε δωρητές, μπορούν, όπως προκύπτει από την επανεξέτασή τους, να προσγραφούν στην ίδια περίοδο. Τα νέα τεκμήρια που προστίθενται στο σώμα των μεσοβυζαντινών επιγραφών του νησιού, δίνουν την αφορμή για μια συνολική αποτίμηση της χορηγικής δραστηριότητας σε αυτό, στην οποία φαίνεται ότι πρωταγωνιστούν κατεξοχήν εύπορα κοσμικά πρόσωπα που συγκροτούσαν την τοπική αρχοντική τάξη.
A note on the literary sources of a painted epigram from Patmos
Authors: ΑΝΤΩΝΟΠΟΥΛΟΥ (Theodora ANTONOPOULOU) Θεοδώρα
Published: September 2024

This short article deals with the identification of the literary sources of an anonymous epigram found on some Patmian icons from the late sixteenth-early seventeenth century, which depict Saint Christodoulos, founder of the Monastery of Patmos. It shows that the epigram draws not only on certain orations by Gregory of Nazianzus, but also on the Life of the saint by John, Metropolitan of Rhodes. Thus, the article sheds light on the education of the versifier (probably Nikephoros Chartophylax), while stressing the Patmian production environment of both the text and the icon imagery that the epigram was destined to accompany.
Δύο άγνωστες επιγραφές του 15ου αιώνα από την Ήπειρο
Authors: ΜΑΝΟΠΟΥΛΟΣ (Gregory MANOPOULOS) Γρηγόρης
Published: September 2024

Η μελέτη παρουσιάζει δύο άγνωστες επιγραφές του 15ου αιώνα από την Ήπειρο. Η πρώτη βρίσκεται στον ναό των Ταξιαρχών στην Ουζντίνα (Πέντε Εκκλησιές) της Θεσπρωτίας και χρονολογείται μεταξύ του 1402 και του 1411. Η δεύτερη εντοπίζεται στον ναό του Προδρόμου στην Αραχοβίτσα (Λευκοθέα) Ιωαννίνων και χρονολογείται στο 1489. Αμφότερες συμβάλλουν στη γνώση μας για τα μνημεία του 15ου αιώνα στην Ήπειρο. Επιπλέον, παρουσιάζονται και άλλες επιγραφές του 16ου και 17ου αιώνα από τους δύο ναούς, που αποσαφηνίζουν τις οικοδομικές φάσεις των μνημείων.
Bell ringing on Mount Athos during the Ottoman period, II: Bells
Authors: SUAREZ Alex Rodriguez
Published: September 2024

This study looks at forty bells found on Mount Athos and which are dated between the 17th and the early 20th century. Because most instruments are still employed by the Athonite community and are usually kept in belfries, these are not very well known artefacts. In fact, many have not been published before. The decoration and inscriptions of each bell are described and examined. Their analysis produces a history of bells on the Holy Mountain during the last three centuries of Ottoman rule.
Once again on the originality of Byzantine architecture in the 11th century: The church of Panagia Chalkeon in Thessaloniki
Authors: ZAKHAROVA Anna
Published: September 2024

The paper analyzes the architectural composition of the Panagia Chalkeon, tracing its possible sources in Constantinople, Thessaloniki, Mount Athos, and underlining its originality. It is demonstrated that the two-storied twin-domed narthex defined the particular features of the church, first and foremost its great height. It became the main reason for the appearance of the two-tiered drum of the dome, the heightened gables etc. As a result, the architectural composition on the whole is dynamic and expressive, without exact parallels elsewhere.
Notes on the construction history and architecture of the Protaton church at Karyes, Mount Athos
Authors: MAMALOUKOS (Σταύρος ΜΑΜΑΛΟΥΚΟΣ) Stavros
Published: September 2024

The church of the Protaton at Karyes, Mount Athos, which has acquired its present form after a long series of alterations, was built in the sixth decade of the 10th century. In its original form it was a large-scale peculiar timber-roofed cross-shaped basilica, which, based on the currently available evidence, constitutes a unicum for Middle Byzantine architecture, as well as one more proof of the existence of originality in Byzantine architecture. The aim of the paper is a reexamination of the construction history and architecture of the monument based mainly on field work.
Η βυζαντινή οχύρωση και η «magna et communis platea» της μεσαιωνικής πόλης της Ρόδου
Authors: ΜΑΝΟΥΣΟΥ-ΝΤΕΛΛΑ (Katerina MANOUSSOU-NTELLA) Κατερίνα
Published: September 2024

Η ένταξη της πρωτοβυζαντινής οχυρωμένης aκρόπολης της Ρόδου στον νευραλγικό χώρο ανάμεσα στα δύο κεντρικά λιμάνια της αρχαίας πόλης αποτέλεσε τομή για τη μετέπειτα εξέλιξη του πολεοδομικού ιστού. Στη νεκρή ζώνη («terra deserta») του νότιου χερσαίου τείχους του κάστρου, έξω από την κεντρική πύλη προς τα ατείχιστα προάστια που περιελήφθησαν τελικά στην οχυρωμένη Χώρα των αρχών του 13ου αιώνα, αναπτύχθηκε ο κεντρικός εμπορικός άξονας που οδηγούσε στον μεσαιωνικό χώρο συναλλαγών και το εμπορικό λιμάνι, και εξελίχθηκε ως «magna et communis platea» της πρωτεύουσας των Ιωαννιτών ιπποτών
Επιγραφική μαρτυρία για τους ζωγράφους του Πρωτάτου. Μια πρώτη παλαιογραφική προσέγγιση
Authors: ΝΑΣΤΟΥ (Andromachi G. NASTOU) Ανδρομάχη  Γ.
Published: September 2024

Οι εργασίες συντήρησης του τοιχογραφικού διακόσμου του ναού του Πρωτάτου στις Καρυές του Αγίου Όρους απέδωσαν, μεταξύ άλλων, μία επιγραφή που διατηρεί γράμματα του ονόματος «Ευτύχιος» και επιτρέπει την ταύτιση του συνεργείου που φιλοτέχνησε τις τοιχογραφίες του ναού, με αυτό των θεσσαλονικέων Μιχαήλ Αστραπά και Ευτυχίου. Στόχος του παρόντος άρθρου είναι να διασαφηνιστεί η συμμετοχή του ενός ή των δύο ζωγράφων στο Πρωτάτο, μέσα από μια συγκριτική παλαιογραφική εξέταση των επιγραφών του καθεδρικού ναού του Αγίου Όρους με τις επιγραφές και τις υπογραφές του συνεργείου στα μνημεία που ιστόρησαν υπό την πατρωνία του κράλη Μιλούτιν.
Die Kuppel und die Frage der “Hierarchisierung”
Authors: Michael ALTRIPP
Published: September 2024

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Athanassios Mailis, Obscured by walls. The Bēma display of the Cretan churches from visibility to concealment
Authors: ΓΚΡΑΤΖΙΟΥ (Olga GRATSIOU) Ολγα
Published: September 2024

Athanassios Mailis, Obscured by walls. The Bēma display of the Cretan churches from visibility to concealment (Byzanz zwischen Orient und Oksident 18), Verlag des Römisch-Germanischen Museums, Mainz 2020, 156 σ. και 212 έγχρωμες και ασπρόμαυρες εικόνες. Στο τέλος περιλαμβάνονται δύο χρονολογικοί κατάλογοι εικονογραφικών θεμάτων 80 συνολικά ναών (σ. 141-142), βιβλιογραφία (σ. 143-153) και ευρετήριο με την τοπογραφική κατάταξη των ναών (σ. 155-156). 30,2×21,5 εκ. ISBN: 978-3795435608.
Μυρτάλη Αχειμάστου-Ποταμιάνου – Αγγελική Κατσιώτη – Μαρία Μπορμπουδάκη, Οἱ τοιχογραφίες τῆς μονῆς τοῦ Βαλσαμονέρου. Ἀπόψεις καὶ φρονήματα τῆς ὕστερης βυζαντινῆς ζωγραφικῆς στὴ βενετοκρατούμενη Κρήτη.
Authors: ΧΑΤΖΗΔΑΚΗ (Nano CHATZIDAKIS) Νανω
Published: September 2024

Μυρτάλη Αχειμάστου-Ποταμιάνου – Αγγελική Κατσιώτη – Μαρία Μπορμπουδάκη, Οἱ τοιχογραφίες τῆς μονῆς τοῦ Βαλσαμονέρου. Ἀπόψεις καὶ φρονήματα τῆς ὕστερης βυζαντινῆς ζωγραφικῆς στὴ βενετοκρατούμενη Κρήτη, έκδοση του Κέντρου Έρευνας της Βυζαντινής και Μεταβυζαντινής Τέχνης της Ακαδημίας Αθηνών, με τη χορηγία του Κοινωφελούς Ιδρύματος Αθανασίου και Μαρίνας Μαρτίνου / ΑΜΚΕ Πολιτιστικού και Κοινωφελούς Έργου «Αιγέας», Αθήνα 2020, 523 σ., 27 σχέδια εντός κειμένου, 114 έγχρωμοι πίνακες. Αγγλική περίληψη: The Frescoes of the Valsamonero Monastery. Viewpoints and Beliefs in the Late Byzantine Painting of Venetian Crete, σ. 459-504. Συντομογραφίες – Βιβλιογραφία, σ. 15-52. Γενικό Ευρετήριο, σ. 505-512, και Εικονογραφικό Ευρετήριο, σ. 513-517. 21,5×29 εκ. ISBN: 978-960-404-376-7.
Διαφωτισμός
Authors: Μέξης Δημήτριος
Published: September 2024

Είναι άραγε η γλώσσα μας μια ασθένεια που καλούμαστε να αντιμετωπίσουμε ή μήπως πρόκειται για την μόνη νοούμενη θεραπεία; Πότε θα πρέπει να εκλάβουμε τον Λόγο ως φάρμακο και πότε ως φαρμάκι; Πώς απαντάνε σε αυτά τα ερωτήματα ο Πλάτων, ο Γοργίας, ο Foscolo και ο Derrida; Τι μας δείχνει εν προκειμένω η λογοτεχνία και γιατί την ορίζουμε ως τον κατεξοχήν θεραπευτικό τόπο μέσα από την ιεροποίηση της συνάντησης; Τι εννοούμε όταν κάνουμε λόγο για λογοτεχνία και για συνάντηση; Μεταξύ ποιων πραγματοποιείται η συνάντηση και γιατί σπεύδουμε να επαναπροσδιορίσουμε την έννοια και τη σημασία της, καταφεύγοντας σε κάθε δυνατή επιστήμη, ούτως ώστε να διασώσουμε, όπως νομίζουμε, την επιστήμη και την αξιοπρέπειά μας;Συνδέεται η επιστήμη με την αξιοπρέπεια και αν ναι πώς; Τι απάντηση δίνουμε κατ' επέκταση στο πώς βιωτέον; Τί μας προτείνει ο Ηράκλειτος, ο Επίκουρος, ο Σενέκας, ο Foscolo, o Wittgenstein και ο Camus;Μπορούμε όμως να μιλήσουμε για τη ζωή δίχως να μιλήσουμε για την ιδέα που έχουμε περί θανάτου; Και αν επιχειρήσουμε να κάνουμε λόγο περί θανάτου, δεν θα βρεθούμε αντιμέτωποι με το αίνιγμα του χρόνου; Και τι είναι λοιπόν ο χρόνος και πώς θα ερμηνεύσουμε εκείνη την αρχαία διάκριση μεταξύ Χρόνου και Καιρού; Τι μας λένε για όλα αυτά τα ερωτήματα οι σύγχρονες φιλοσοφικές και λογοτεχνικές σκηνές, από τον Celine και τον Ηοuellebecq ως τον Bergson και τον Jankélévitch, πώς ερμηνεύουμε εμείς τούτες τις σκηνές και τι δημιουργούμε στο κατώφλι του μετασύμπαντος και του μετανθρώπου; Αυτά είναι ορισμένα μονάχα από τα βασικά ερωτήματα του παρόντος κειμενικού εγχειρήματος, το οποίο επανεγγράφει στη νεωτερικότητα το έργο του Ugo Foscolo, μέσα από έναν διάλογο με την ιστορία της φιλοσοφίας και του δυτικού πολιτισμού, προσκαλώντας τον αναγνώστη - δημιουργό σε μια συνάντηση με φιλολογικές και φιλοσοφικές προσεγγίσεις που ως τελικό στόχο φαίνεται να έχουν τη διάσωση της επιστήμης, της ποίησης και της αξιοπρέπειας.