bluuebunny/crossref_metadata_2025 huggingface dataset:
Previous Solid Organ Transplantation Influences Both Cancer Treatment and Survival Among Colorectal Cancer Patients
Authors: Benoni Henrik , Nordenvall Caroline , Hellström Vivan , Dietrich Caroline E. , Martling Anna , Smedby Karin E. , Eloranta Sandra
Published: September 2024

Previous solid organ transplantation has been associated with worse survival among colorectal cancer (CRC) patients. This study investigates the contribution of CRC characteristics and treatment-related factors to the differential survival. Using the Swedish register-linkage CRCBaSe, all patients with solid organ transplantation before CRC diagnosis were identified and matched with non-transplanted CRC patients. Associations between transplantation history and clinical CRC factors and survival were estimated using the Kaplan-Meier estimator and logistic, multinomial, and Cox regression, respectively. Ninety-eight transplanted and 474 non-transplanted CRC patients were followed for 5 years after diagnosis. Among patients with stage I-III cancer, transplanted patients had lower odds of treatment with abdominal surgery [odds ratio (OR):0.27, 95% confidence interval (CI):0.08–0.90], than non-transplanted patients. Among those treated with surgery, transplanted colon cancer patients had lower odds of receiving adjuvant chemotherapy (OR:0.31, 95% CI:0.11–0.85), and transplanted rectal cancer patients had higher rate of relapse (hazard ratio:9.60, 95% CI:1.84–50.1), than non-transplanted patients. Five-year cancer-specific and overall survival was 56% and 35% among transplanted CRC patients, and 68% and 57% among non-transplanted. Accordingly, transplanted CRC patients were treated less intensely than non-transplanted patients, and had worse cancer-specific and overall survival. These patients might benefit from multidisciplinary evaluation including transplantation specialists.
Knowledge Graph Construction Method for Commercial Aircraft Fault Diagnosis Based on Logic Diagram Model
Authors: Peng Huanchun , Yang Weidong
Published: September 2024

Commercial aircraft fault diagnosis is an important means to ensure the reliability and safety of commercial aircraft. Traditional knowledge-driven and data-driven fault diagnosis methods lack interpretability in engineering mechanisms, making them difficult to promote and apply. To address the issue of lack of interpretability, this paper conducts a fault knowledge graph for commercial aircraft fault diagnosis, using the fault logic in the logic diagram to increase the interpretability of diagnostic work. Firstly, to avoid the inefficiency of logic diagram applications, an executable logic diagram model is established, which can perform mathematical analysis and achieve fault diagnosis and localization using operational data as input. Then, the logic diagram is sorted out to obtain the hidden fault knowledge in the logic diagram, which is used to construct a fault knowledge graph to help achieve cause localization and rapid troubleshooting. The methods proposed in this paper are all validated through case studies of abnormal low-pressure faults in domestic commercial aircraft hydraulic systems. The results show that the logic diagram model can perform model simulation and fault diagnosis based on operational data, and the fault knowledge graph can quickly locate abnormal monitoring parameters and guide troubleshooting work based on existing information.
The Impact of Different Telerehabilitation Methods on Peripheral Muscle Strength and Aerobic Capacity in COPD Patients: A Randomized Controlled Trial
Authors: Ataç Amine , Pehlivan Esra , Karaahmetoğlu Fulya Senem , Özcan Zeynep Betül , Çınarka Halit , Çörtük Mustafa , Baydili Kürsad Nuri , Çetinkaya Erdoğan
Published: September 2024

Lung diseases have profound effects on the aging population. We aimed to hypothesize and investigate the effect of remote pulmonary telerehabilitation and motor imagery (MI) and action observation (AO) methods on the clinical status of elderly chronic obstructive pulmonary disease (COPD) patients. Twenty-six patients were randomly assigned to pulmonary telerehabilitation (PtR) or cognitive telerehabilitation (CtR) groups. The programs were carried out 3 days a week for 8 weeks. The 6-min walk test (6MWT), modified Medical Research Council dyspnea score, blood lactate level (BLL), measurement of peripheral muscle strength (PMS), and electromyography activation levels of accessory respiratory muscles were the main outcomes. There was a statistically significant improvement (p < 0.05) in both groups in the 6MWT distance and in secondary results, except for BLL. Generally, in the mean muscle activity obtained from the electromyography measurement after the program, there were statistically significant increases in the PtR group and decreases in the CtR group (p < 0.05). There was a statistically significant increase in PMS in both groups. An active muscle-strengthening program has the same benefits as applying the muscle-strengthening program to the patient as MI and AO. CtR can be a powerful alternative rehabilitation method in respiratory patients who cannot tolerate active exercise programs.
Technology for Obtaining Sintered Components with Tailored Electromagnetic Features by Selective Recycling of Printed Circuit Boards
Authors: Ciobanu Romeo Cristian , Aradoaei Mihaela , Schreiner Cristina
Published: September 2024

The paper presents a technological approach for obtaining sintered components with tailored electromagnetic features from electromagnetically active powders through the selective recycling of electronic waste, in particular scrap electronic components. Printed circuit board (PCB) scraps were submitted to a succession of grinding processes, followed by progressive magnetic and electrostatic separation, resulting two final fractions: metallic particles and non-metallic particles including different metallic oxides. Three types of powders were analyzed, i.e., powder after fine grinding, after magnetic separation and after electrostatic separation, which were further processed within a spark plasma sintering furnace in order to obtain solid disk samples. All samples contained several classes of oxides, and also residual metals, leading to specific thermal decomposition processes at different temperatures, depending on the nature of the oxides present in the studied materials. The chemical analysis of powders, via spectrometry with X-ray fluorescence—XRF, emphasized the presence of a mixture of metal oxides and traces of metals (mainly Ag), with concentrations diminishing along with the purification process. The most important analysis was related to dielectric parameters, and it was concluded that the powders obtained by the proposed technology could efficiently substitute scarce raw materials actually used as additives in composites, coatings and paints, mainly due to their high permittivity (above 6 in all frequency domains) and, respectively, dielectric loss factor (above 0.2 in all cases, in all frequency domains). We estimate that the technology described in this paper is a sustainable one according to the concept of circular economy, as it could reduce, by a minimum of 15%, the embodied GHG emissions generated from information and communications technology (ICT) devices by advanced recycling.
A Rapid Increase in Serum Lactate Levels after Cardiovascular Surgery Is Associated with Postoperative Serious Adverse Events: A Single Center Retrospective Study
Authors: Kikuchi Kenichiro , Kazuma Satoshi , Masuda Yoshiki
Published: September 2024

Background/Objectives: Hyperlactatemia is a common predictive factor for poor post-cardiovascular surgery outcomes. However, it is not well understood whether the rapid postoperative lactate level elevation in a short period of time is associated with patient outcomes. Herein, we investigated the relationship between the degree of change in serum lactate levels and postoperative serious adverse events (PSAEs), including mortality, within 24 h of cardiovascular surgery. Methods: In this retrospective study, we evaluated the relationship between a rapid serum lactate level increase and PSAEs after open-heart and major vascular surgery. We divided the patients into those with and without PSAEs. Univariate and multivariate analyses were performed to evaluate the association between PSAEs and rapid lactate level increases. Results: We enrolled 445 patients; 16% (n = 71) had PSAEs. The peak lactate levels during the first 24 h of intensive care unit (ICU) stay were higher in patients with PSAEs than in those without. The maximum change in lactate levels between two consecutive lactate measurements during the first 24 h after ICU admission was higher in patients with PSAEs than in those without. A multivariate logistic regression analysis revealed that changes in lactate levels of 2 mmol/L or more between two consecutive lactate measurements were associated with PSAEs. ICU peak lactate levels of 3 mmol/L or more were not associated with PSAEs. Conclusions: Rapid serum lactate level increases of 2 mmol/L or more during the first 24 h of ICU admission post-cardiovascular surgery are associated with PSAEs.
Method for Augmenting Side-Scan Sonar Seafloor Sediment Image Dataset Based on BCEL1-CBAM-INGAN
Authors: Xia Haixing , Cui Yang , Jin Shaohua , Bian Gang , Zhang Wei , Peng Chengyang
Published: September 2024

In this paper, a method for augmenting samples of side-scan sonar seafloor sediment images based on CBAM-BCEL1-INGAN is proposed, aiming to address the difficulties in acquiring and labeling datasets, as well as the insufficient diversity and quantity of data samples. Firstly, a Convolutional Block Attention Module (CBAM) is integrated into the residual blocks of the INGAN generator to enhance the learning of specific attributes and improve the quality of the generated images. Secondly, a BCEL1 loss function (combining binary cross-entropy and L1 loss functions) is introduced into the discriminator, enabling it to focus on both global image consistency and finer distinctions for better generation results. Finally, augmented samples are input into an AlexNet classifier to verify their authenticity. Experimental results demonstrate the excellent performance of the method in generating images of coarse sand, gravel, and bedrock, as evidenced by significant improvements in the Frechet Inception Distance (FID) and Inception Score (IS). The introduction of the CBAM and BCEL1 loss function notably enhances the quality and details of the generated images. Moreover, classification experiments using the AlexNet classifier show an increase in the recognition rate from 90.5% using only INGAN-generated images of bedrock to 97.3% using images augmented using our method, marking a 6.8% improvement. Additionally, the classification accuracy of bedrock-type matrices is improved by 5.2% when images enhanced using the method presented in this paper are added to the training set, which is 2.7% higher than that of the simple method amplification. This validates the effectiveness of our method in the task of generating seafloor sediment images, partially alleviating the scarcity of side-scan sonar seafloor sediment image data.
Calcium-Dependent Chemiluminescence Catalyzed by a Truncated c-MYC Promoter G-Triplex DNA
Authors: Das Malay Kumar , Williams Elizabeth P. , Myhre Mitchell W. , David Wendi M. , Kerwin Sean M.
Published: September 2024

The dynamic landscape of non-canonical DNA G-quadruplex (G4) folding into G-triplex intermediates has led to the study of G-triplex structures and their ability to serve as peroxidase-mimetic DNAzymes. Here we report the formation, stability, and catalytic activity of a 5′-truncated c-MYC promoter region G-triplex, c-MYC-G3. Through circular dichroism, we demonstrated that c-MYC-G3 adopts a stable, parallel-stranded G-triplex conformation. The chemiluminescent oxidation of luminol by the peroxidase mimicking DNAzyme activity of c-MYC-G3 was increased in the presence of Ca2+ ions. We utilized surface plasmon resonance to characterize both c-MYC-G3 G-triplex formation and its interaction with hemin. The detailed study of c-MYC-G3 and its ability to form a G-triplex structure and its DNAzyme activity identifies issues that can be addressed in future G-triplex DNAzyme designs.
Developments and Applications of Molecularly Imprinted Polymer-Based In-Tube Solid Phase Microextraction Technique for Efficient Sample Preparation
Authors: Kataoka Hiroyuki , Ishizaki Atsushi , Saito Keita , Ehara Kentaro
Published: September 2024

Despite advancements in the sensitivity and performance of analytical instruments, sample preparation remains a bottleneck in the analytical process. Currently, solid-phase extraction is more widely used than traditional organic solvent extraction due to its ease of use and lower solvent requirements. Moreover, various microextraction techniques such as micro solid-phase extraction, dispersive micro solid-phase extraction, solid-phase microextraction, stir bar sorptive extraction, liquid-phase microextraction, and magnetic bead extraction have been developed to minimize sample size, reduce solvent usage, and enable automation. Among these, in-tube solid-phase microextraction (IT-SPME) using capillaries as extraction devices has gained attention as an advanced “green extraction technique” that combines miniaturization, on-line automation, and reduced solvent consumption. Capillary tubes in IT-SPME are categorized into configurations: inner-wall-coated, particle-packed, fiber-packed, and rod monolith, operating either in a draw/eject system or a flow-through system. Additionally, the developments of novel adsorbents such as monoliths, ionic liquids, restricted-access materials, molecularly imprinted polymers (MIPs), graphene, carbon nanotubes, inorganic nanoparticles, and organometallic frameworks have improved extraction efficiency and selectivity. MIPs, in particular, are stable, custom-made polymers with molecular recognition capabilities formed during synthesis, making them exceptional “smart adsorbents” for selective sample preparation. The MIP fabrication process involves three main stages: pre-arrangement for recognition capability, polymerization, and template removal. After forming the template-monomer complex, polymerization creates a polymer network where the template molecules are anchored, and the final step involves removing the template to produce an MIP with cavities complementary to the template molecules. This review is the first paper to focus on advanced MIP-based IT-SPME, which integrates the selectivity of MIPs into efficient IT-SPME, and summarizes its recent developments and applications.
Meron-Mediated Phase Transitions in Quasi-Two-Dimensional Chiral Magnets with Easy-Plane Anisotropy: Successive Transformation of the Hexagonal Skyrmion Lattice into the Square Lattice and into the Tilted FM State
Authors: Leonov Andrey O.
Published: September 2024

I revisit the well-known structural transition between hexagonal and square skyrmion lattices and subsequent first-order phase transition into the tilted ferromagnetic state as induced by the increasing easy-plane anisotropy in quasi-two-dimensional chiral magnets. I show that the hexagonal skyrmion order first transforms into a rhombic skyrmion lattice, which, adjusts into a perfect square arrangement of skyrmions (“a square meron-antimeron crystal”) within a narrow range of anisotropy values. These transitions are mediated by merons and anti-merons emerging in the boundaries between skyrmion cells; energetically unfavorable anti-merons annihilate, whereas pairs of neighboring merons merge. The tilted ferromagnetic state sets in via mutual annihilation of oppositely charged merons; as an outcome, it contains bimeron clusters (chains) with the attracting inter-soliton potential. Additionally, I demonstrate that domain-wall merons are actively involved in the dynamic response of the square skyrmion lattices. As an example, I theoretically study spin–wave modes and their excitations by AC magnetic fields. Two found resonance peaks are the result of the complex dynamics of the domain-wall merons; whereas in the high-frequency mode the merons rotate counterclockwise, as one might expect, in the low-frequency mode merons are instead created and annihilated consistently with the rotational motion of the domain boundaries.
Study on Hydraulic Fracture Propagation in Mixed Fine-Grained Sedimentary Rocks and Practice of Volumetric Fracturing Stimulation Techniques
Authors: Mao Hong , Shen Yinghao , Yuan Yao , Wu Kunyu , Xie Lin , Huang Jianhong , Xing Haoting , Wan Youyu
Published: September 2024

Yingxiongling shale oil is considered a critical area for future crude oil production in the Qaidam Basin. However, the unique features of the Yingxiongling area, such as extraordinary thickness, hybrid sedimentary, and extensive reformation, are faced with several challenges, including an unclear understanding of the main controlling factors for hydraulic fracturing propagation, difficulties in selecting engineering sweet layers, and difficulties in optimizing the corresponding fracturing schemes, which restrict the effective development of production. This study focuses on mixed fine-grained sedimentary rocks, employing a high-resolution integrated three-dimensional geological-geomechanical model to simulate fracture propagation. By combining laboratory core experiments, a holistic investigation of the controlling factors was conducted, revealing that hydraulic fracture propagation in mixed fine-grained sedimentary rocks is mainly influenced by rock brittleness, natural fractures, stress, varying lithologies, and fracturing parameters. A comprehensive compressibility evaluation standard was established, considering brittleness, stress contrast, and natural fracture density, with weights of 0.3, 0.23, and 0.47. In light of the high brittleness, substantial interlayer stress differences, and localized developing natural microfractures in the Yingxiongling mixed fine-grained sedimentary rock reservoir, this study examined the influence of various construction parameters on the propagation of hydraulic fractures and optimized these parameters accordingly. Based on the practical application in the field, a “three-stage” stimulation strategy was proposed, which involves using high-viscosity fluid in the front to create the main fracture, low-viscosity fluid with sand-laden slugs to create volume fractures, and continuous high-viscosity fluid carried sand to maintain the conductivity of the fracture network. The resulting oil and gas seepage area corresponding to the stimulated reservoir volume (SRV) matched the actual well spacing of 500 m, achieving the effect of full utilization. The understanding of the controlling factors for fracture expansion, the compressibility evaluation standard, and the main process technology developed in this study effectively guide the optimization of transformation programs for mixed fine-grained sedimentary rocks.
Cold Chain Distribution Route Optimization for Mixed Vehicle Types of Fresh Agricultural Products Considering Carbon Emissions: A Study Based on a Survey in China
Authors: Pan Shuangli , Liao Huiyu , Zheng Guijun , Huang Qian , Shan Maozhuo
Published: September 2024

With the improvement of people’s living standards and the widening of circulation channels, the demand for fresh agricultural products continues to increase. The increase in demand will lead to an increase in delivery vehicles, costs, and carbon emissions, among which the increase in carbon emissions will aggravate pollution and is not conducive to sustainable development. Therefore, it is very important to balance economic and environmental benefits in the distribution of fresh agricultural products. Based on the analysis of the distribution characteristics of fresh agricultural products, this paper studies the optimization of the cold chain distribution route of fresh agricultural products considering carbon emission. Firstly, the cold chain distribution route planning of fresh agricultural products was investigated and analyzed by the interview method, and the basis for establishing the model objective and constraint conditions was obtained. Then, taking the minimum total cost including carbon emission cost as the optimization goal, the cold chain distribution route optimization model for mixed vehicle types is established considering electric refrigerated vehicles, gasoline refrigerated vehicles, and so on. Genetic algorithm was used to solve the model, and MATLAB2018b was used to substitute specific case data for simulation analysis. The analysis results show that increasing the consideration of carbon emission and mixed vehicle types in the distribution route of fresh agricultural products can not only reduce the distribution cost but also reduce the carbon emission. To some extent, the research content of this paper can provide a reference for enterprises in planning cold chain distribution routes of fresh agricultural products.
Review on Circularity in the Electric Vehicle (EV) Industry
Authors: Leong Jun Yang
Published: September 2024

The growing electric vehicle (EV) sector, while tackling climate issues, also encounters obstacles concerning resource usage and a rise in EV disposal. This study examines the circularity framework in the EV sector to address these problems, emphasizing the importance of reusing and upcycling resources for sustainability. Moreover, numerous nations have implemented recycling and R&D policies to offer legal and policy backing for the advancement of recycling technology. This report will investigate and contrast various recycling technologies. Furthermore, it involves an examination of key figures in the EV sector to identify deficiencies in the EV materials supply chain and tactics for minimizing waste. Conversations with a variety of EV stakeholders will provide perspectives on the creative methods businesses are implementing to tackle these obstacles. By embracing the principles of a circular economy, the EV industry can act as a model for a sustainable future, decreasing its environmental footprint and encouraging a more efficient use of resources.
Establishment and ecological integration of the New Zealand mud snail in Spirit Lake, Mount St. Helens, Washington State, USA
Authors: Myers Shaina R. , Germeau Hailey E. , McCann Meghan , Cranston Wyatt , Crisafulli Charles M. , Fox-Dobbs Kena , Gawel James E.
Published: September 2024

Mount St. Helens National Volcanic Monument was designated by the U.S. Congress in 1982 to conserve the landscape for natural regeneration, scientific research, education, and cultural resource preservation. However, this designation has not eliminated threats from the introduction of non-native species. The non-native New Zealand mud snail (NZMS), Potamopyrgus antipodarum, was first observed in 2016 along the SW shore of Spirit Lake at the foot of Mount St. Helens, despite the lake’s closure to public recreation and isolation from other known sites harboring NZMS. Our study mapped native and non-native snails on aquatic macrophytes in Spirit Lake, analyzed NZMS eDNA in Spirit Lake and surrounding waters, measured stable isotopes in snails and their food sources, and analyzed rainbow trout (Oncorhynchus mykiss) gut contents from a twenty-year survey to examine the patterns of spatial distribution, habitat occurrence, and resource use. Our results show that NZMS colonies were likely first established along the SW shore of Spirit Lake in 2015, and presently remain largely confined to the vegetated littoral zone along this same shoreline. The native snail species Gyraulus deflectus and NZMS co-occur on multiple macrophyte species, and δ¹⁵N and δ¹³C isotope data reveal they are consuming the same food sources, but no evidence was seen for competitive exclusion. The abundance and frequency of NZMS found in rainbow trout gut contents have increased since 2015 with a significant portion undigested. In addition, stable isotope analysis shows a negligible trophic tie between snails (both NZMS and G. deflectus) and rainbow trout, which may signal longer-term impacts on fish populations. Characterizing this invasion spatially and temporally elucidates the factors facilitating and hindering the spread of NZMS in a relatively young and dynamic subalpine lake ecosystem closed to public recreation, and may inform current and future management decisions.
Mobile Podcast Production: How to Educate and Engage through Online Audio
Authors: Aenlle Jacqueline , Stone Whitney , Beattie Peyton , Loizzo Jamie
Published: September 2024

The use of podcasts in Cooperative Extension programs continues to grow. Ongoing research shows the benefits of podcasting for formal education, non-formal education, connecting with distance learning, and reaching a broader audience. This article will provide readers with steps to create an educational podcast. This article will be of interest for Extension agents and Extension programs that are moving to, or can be complemented by, a digital platform. Extension professionals can consider using podcasts and podcast analytics to complement existing programming, impact reporting, and promotion.
Investigating the Use of Lesson Study as a Professional Development Model for 4-H Educators at 1890 Land Grant Universities
Authors: Pierfax Cynthia , Free Travella , Franklin Tiffany , Erby Manola , Schmitt-McQuitty Lynn , Meehan C , Smith Martin
Published: September 2024

There is a defined need to provide accessible and effective professional development for 4-H educators. Lesson study is a Community of Practice-based approach to educator professional development. Prior research has shown lesson study to be effective with 4-H staff, adult volunteers, and teen volunteers. This inquiry, a multi-site case study, was designed to investigate the application of lesson study in authentic contexts with 4-H county agents from 1890 land-grant universities. Quantitative and qualitative measures revealed improved preparedness, participation, and camaraderie among participating educators. Other benefits to participants included improved lesson planning and implementation.
The role of real estate agents and digital media to first home buyers in the North Island of New Zealand
Authors:   , Velez Rochelle
Published: September 2024

The first home buyers' journey in the North Island of New Zealand is a complex and multifaceted process influenced by various factors, including the role of real estate agents and digital media. This research explores the role of these two factors and their impact on the decision making process of first home buyers. Data was gathered using a mixed methods approach that combined surveys and interviews to examine the experiences and challenges that first home buyers encountered when utilising real estate agents and digital media during the home buying process. The findings revealed the interrelated role of real estate agents and digital media in the first home buying journey. Real estate agents act as information resource, and advisory role. They are trusted experts who provide first home buyers with valuable information, market insights, and negotiation support that help them make informed decisions. At the same time, digital media helps first home buyers by triggering home search, providing access to vast amounts of information, easing house searches, give valuable visual content, and helping in the overall decision making process. First home buyers are better able to navigate the real estate market and make informed decisions regarding their first home purchased when digital media is used properly. Combining the support of real estate agents and digital media creates an optimal environment for aspiring first home buyers, facilitating well-informed decisions throughout their first home buying journey. However, challenges such as difficulty in finding the right house, understanding the home buying process, complete transparency, and accuracy of information pose hurdles for first home buyers. By understanding these dynamics, stakeholders in the real estate industry can better support first home buyers and enhance their overall first home buying experience.
Pyoderma Gangrenosum Tanılı Hastaların Klinik Özelliklerinin, Komorbiditelerinin ve Tedavi Yanıtlarının Retrospektif Olarak İncelenmesi
Authors: Çetinarslan Tubanur , Masat Abdullah Kutay , Şahin Mustafa Turhan , Türel Ermertcan Aylin
Published: September 2024

Giriş ve Amaç: Pyoderma gangrenozum [PG], hızlı ilerleyen, düzensiz eritematöz kenarlı ağrılı deri ülserleri ile seyreden nadir bir nötrofilik dermatozdur. PG'nin nedeni tam olarak anlaşılamamıştır, ancak genellikle otoinflamatuar bir bozukluk olarak kabul edilir. Klinik bulguların yanı sıra histopatolojik inceleme tanı koymada yardımcı olabilir.
Gereç ve Yöntemler: 2012-2024 yılları arasında kliniğimize başvuran ve klinik ve histopatolojik olarak PG tanısı alan hastalar çalışmamıza dahil edildi. Çalışmamızda hastaların yaş, cinsiyet, lezyon yerleşim yeri, tetikleyici faktör, ek hastalıkları, aldıkları tedavi ve tedaviye yanıtları incelendi.
Bulgular: Çalışmaya toplam 25 PG tanılı hasta dahil edildi. 25 hastanın 17’si kadın, 8’i erkek idi. Olguların tamamında histopatolojik inceleme ile PG tanısı desteklendi. 17 hastada tetikleyici faktör bulunamazken, en çok suçlanan tetikleyici faktör cerrahi işlemler idi ve bunu sırasıyla travma ve egzoz yanığı takip etmekteydi. Hastalara PG tedavisinde en sık sistemik metilprednizolon verilirken [18 hasta], bunu sırasıyla topikal steroid [9 hasta], intravenöz immunglobulin [İVİG] [8 hasta], siklosporin [5 hasta], intralezyonel triamsinolon asetonid [3 hasta], topikal takrolimus [2 hasta], mikofenolat mofetil [1 hasta] ve topikal kalsipotriol [1 hasta] takip etmekteydi. Hastaların 13’ünde sistemik steroidler ile diğer tedaviler kombine kullanılırken, 11’i monoterapi ile tedavi edildi. Çalışmamızdaki olguların 3’ü sadece sistemik steroidlere, 5’i hem sistemik steroidlere hem siklosporine dirençliydi ve bu 8 hastada İVİG tedavisi ile yanıt alındı.
Sonuç: PG tedavisinde sistemik steroidler ve siklosporinin kanıt düzeyi 1b olup birinci basamak tedavide yer almaktadırlar. PG’da birinci basamak tedavi seçenekleri olan sistemik steroidler ve siklosporine dirençli olgularda, İVİG kanıt düzeyi 3a olmasına rağmen, iyi bir seçenek olarak görünmektedir.

Anahtar kelimeler: pyoderma gangrenosum, intravenöz immunglobulin, İVİG, nötrofilik dermatoz, ülser, inflamatuar bağırsak hastalığı
Desarrollo del prototipo de la balanza de kibble con material didáctico
Authors: Jiménez Julio César Díaz , Morales Andrea Olvera , Silva Juana María Martínez , Monjarras Oscar Licon , Gómez Edurado Romero , Robles Jesús Daniel Salazar , Campos María Eugenia Edith Zapata
Published: September 2024

Existen diferentes actividades científicas y educativas en las que se pueden aplicar los conceptos de la física para desarrollar sistemas de medición que permitan conocer los valores de diferentes propiedades para un fin específico. Las definiciones de las 7 unidades base del Sistema Internacional de Unidades han permanecido por mucho tiempo, actualmente la definición del kilogramo que ha estado vigente por más de 120 años será oficialmente redefinida y hay dos propuestas posibles, una de ellas se basa en un dispositivo conocido como balanza de Kibble. El NIST desarrolló un prototipo de dicha balanza mediante materiales didácticos (bloques lego) pero funcional ya que incluye todos los elementos para poder funcionar con una incertidumbre de hasta 10%. En la universidad politécnica de santa Rosa Jáuregui se han tratado de desarrollar diferentes actividades que permitan a los estudiantes adquirir y aplicar los conceptos para su formación, por tal motivo se presenta el desarrollo de un prototipo de balanza de Kibble.
ГРИГОРІЙ СКОВОРОДА – КЛЮЧОВА ПОСТАТЬ В УКРАЇНСЬКІЙ ДУХОВНІЙ ТРАДИЦІЇ ВІД ДАВНИНИ ДО СУЧАСНОСТІ
Authors: Бойчук Ю. , Левченко Н.
Published: September 2024

Протягом трьохсот років світ сприймає Сковороду як новочасного поета-містика, фундатора української “філософії серця”, мислителя, християнського філософа, який окреслив гуманістичні контури української ідентичності. Саме тому росія, намагаючись знищити Україну й українців в нинішній російсько-українській війні, прицільно вдарила ракетами в ніч на сьоме травня по будівлях, безпосередньо пов’язаних з постаттю Григорія Сковороди, який був, є і завжди буде віддзеркаленням ментальності українського народу, – Національному літературно-меморіальному музею Г. С. Сковороди в Сковородинівці, а в ніч на сьоме липня – по Харківському національному педагогічному університету, який носить ім’я Сковороди. В обох закладах чудом в епіцетрі вибухів вціліли пам’ятники українського барокового інтелектуала, ніби заохочуючи нас, його нащадків, множити подібні чудеса, зберігаючи найменші паростки пам’яті про нього.
Czy uczenie się powoduje chaos komunikacyjny?
Authors: Kosiorowski Grzegorz
Published: September 2024

Jest to tekst związany z odczytem wygłoszonym na LXV Szkole Matematyki Poglądowej, Uogólnienia, Siedlce, sierpień 2022.
Dlaczego pokrywy studzienek kanalizacyjnych są okrągłe?
Authors: Bartnicki Tomasz , Miechowicz Zofia
Published: September 2024

Jest to tekst związany z odczytem wygłoszonym na LXIII Szkole Matematyki Poglądowej, Ograniczenia, online, sierpień 2021.
O książce "Matematyka z różnych stron widziana"
Authors: Strzelecki Paweł
Published: September 2024

Recenzja książki Matematyka z różnych stron widziana.
O statystyce bez kompleksów
Authors: Pogoda Zdzisław
Published: September 2024

Recenzja książki Statystycznie rzecz biorąc.
Co historykowi do katastrof? Wspomnienie Czarnobyla, 1986
Authors: Kula Marcin
Published: September 2024

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Alicja Urbanik-Kopeć, Matrymonium. O małżeństwie nieromantycznym, Wydawnictwo Czarne, Warszawa 2022
Authors: Chilimoniuk Ks. Radosław
Published: September 2024

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IV Ogólnopolska Konferencja Naukowa „Społeczeństwo w wojsku, wojsko w społeczeństwie w XIX i XX wieku. Relacje i procesy w ujęciu interdyscyplinarnym” (15-16 czerwca 2023 r., Dęblin)
Authors: Orłowski Paweł
Published: September 2024

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Kulturowe wyznaczniki wizerunku nowoczesnej Polki w czasopiśmie „Kobieta w Domu i Salonie”
Authors: Maj Ewa
Published: September 2024

Międzywojenna prasa dla Polek wypełniała misję edukacyjną i wychowawczą. Na rynku znajdowały się czasopisma dla różnych czytelniczek. Przypadek periodyku „Kobieta w Domu i Salonie” potwierdzał dążność do pozyskania odbiorczyń , którym oferowano wizję nowoczesnej Polki. Czytelniczka otrzymywała przekaz, zawierający odwołania do wartości, jak tradycjonalizm, wiara religijna, rodzimość, kultywowanie przeszłości, zachowawczość. W publicystyce ujawniała się gotowość do umiarkowanego korygowania stereotypów płci i do łagodnego modernizowania obyczajowości. Nowoczesna Polka miała być osobą odpowiednio przygotowaną do pełnienia ról społecznych żony, matki, opiekunki, wychowawczyni młodego pokolenia.
Czasopisma na temat obszaru poradzieckiego w Polsce w latach 1989-2013
Authors: Borowik Bogdan
Published: September 2024

W artykule podjęto próbę opisu segmentu czasopism dotyczących Rosji, państw Europy Środkowo-Wschodniej, Azji Centralnej i Kaukazu Południowego w latach 1989-2013, czyli przed agresją militarną Rosji na Ukrainę. Prawie cały omawiany obszar w dużej części XX wieku wchodził bezpośrednio w skład Związku Radzieckiego lub podlegał pośredniej zależności polityczno-militarnej w ramach Układu Warszawskiego. Państwa Europy Wschodniej, Azji Centralnej i Kaukazu Południowego również współcześnie stanowią przedmiot zainteresowania Federacji Rosyjskiej. Większość ważnych wydarzeń politycznych, ekonomicznych i społecznych, zarówno w Rosji, jak i w innych państwach obszaru postsowieckiego, wpływa na naszą sytuację geopolityczną, głównie w kontekście bezpieczeństwa zewnętrznego Polski i umacniania jej pozycji w regionie Europy Środkowo-Wschodniej oraz w Unii Europejskiej. W części drugiej artykułu wymienione zostały cechy wspólne omawianych pism. W kilku wyodrębnionych grupach opisano poszczególne periodyki. Podjęta została też próba oceny znaczenia omawianego segmentu czasopism w procesie wypracowywania koncepcji kształtujących politykęwschodnią polskiego rządu w omawianym okresie.
INFLUENCE OF STRESS COPING BEHAVIOR ON THE EMOTIONAL LOAD OF TEACHERS
Authors: Petkov Tsvetan
Published: September 2024

In connection with the intensification of professional activity and the acceleration of the pace of life of a modern person, the problem of the relationship between behavior to overcome stress and emotional load and the development of individual coping resources is becoming more and more relevant. There is a rather limited number of scientific works dedicated to the study of the problem of overcoming the emotional burden of teachers working with children, as well as the maintenance and development of individual coping resources. Teachers from the regional state educational institution (30 people) took part in the study. Observation, interview, and standardized testing techniques were used to diagnose teacher workload and behavioral strategies for coping with stress. Mathematical and statistical analysis methods were used to process the results.
Teachers who prefer non-constructive overcoming of professional difficulties, inadequately limit the scope and intensity of inclusion of emotions in professional communication (called „Inadequate emotional selective reaction“, which has an average value of Ẋav.=18.6), They seek to ease or reduce professional responsibilities requiring emotional costs. To a greater extent, those teachers who use constructive coping are aware of the psychotraumatic factors of professional activity and experience emotional emptiness and fatigue. Positive correlations were found between non-constructive coping („aggressive actions”) and all phases of emotional burnout („tension”; „resistance”; „exhaustion”:). Aggression directed at others as a counterproductive coping strategy has been empirically shown to contribute to job frustration and job dissatisfaction and loss of professional interest. In other words, the professional stress experienced by teachers exceeds their coping resources, and the defensive-adaptive mechanism of behavior to overcome stress takes place at the level of psychological protection.
PRESERVATION AND PROMOTION OF MATERIAL CULTURAL HERITAGE: A COMPARATIVE ANALYSIS OF THE REPUBLIC OF SERBIA AND THE REPUBLIC OF NORTH MACEDONIA
Authors: Penjišević Aleksandra , Sančanin Branislav , Dimitrijovska Jankulovska Anita , Denkovska Milica
Published: September 2024

This study aims to assess the state of material cultural heritage in the Republic of Serbia and the Republic of North Macedonia, focusing on identification and promotion at both national and international levels, with an emphasis on digitization and improving the register of cultural assets. The recommended approach, which supports sustainable development, not only enables the comprehensive protection of all cultural resources, adding new value, but also minimizes the risk of permanent loss. The authors stress the importance of ongoing efforts to identify previously undiscovered cultural heritage and protect it from damage, decay, neglect, and theft. Given that cultural heritage is continuously exposed to natural elements and human activities, policymakers are encouraged to further raise awareness of cultural values and recognize threats arising from the short-term interests of local communities, which might result in erosion and loss of protected cultural monuments and landscapes.
The research utilized an opportunistic, convenience sampling method, surveying residents of the Republic of Serbia and the Republic of North Macedonia across five or eight regions (n1=163, n2=96, n=259). The findings revealed that 77% of respondents believe the protection of material cultural heritage is inadequate. Citizens of the Republic of Serbia identified unsatisfactory maintenance and a lack of financial resources as the greatest threats, while respondents from the Republic of North Macedonia pointed to unsatisfactory maintenance and weak enforcement of management regulations as their primary concerns. The research also indicated that individuals with advanced degrees (Magister, Master, and Doctor of Science) have a better understanding of material cultural heritage. Overall, the primary cause cited for a good knowledge of material cultural heritage was an interest in customs and traditions, while the key reason for insufficient knowledge was the lack of media representation.
FACTORS INFLUENCING JOB CHANGE WITH RELOCATION AND EMPLOYEE SATISFACTION IN IT COMPANIES
Authors: Kukolj Saša , Deretić Nemanja , Adžić Slobodan
Published: September 2024

This paper investigates the key factors influencing job change with relocation and employee satisfaction, using statistical data analysis segmented by categories such as age group, gender, work experience, education level, and position within IT companies. The research is based on a sample of 161 employees in IT companies, selected through purposive sampling. The Mann-Whitney U test analysis revealed that men place more value on professional development and career advancement opportunities, while women give greater importance to work-life balance, preferring flexible working conditions. According to the Kruskal-Wallis test, differences are also evident among age groups: employees younger than 31 years prioritize professional development and exploring new opportunities, while those over 40 value quality of life and security. Employees in the middle age group (31-40 years) balance between these priorities. Regarding education, the results show that individuals with a high school education focus on stability and financial incentives, while those with higher education aim for career advancement and greater flexibility. Employees with master's degrees seek specialized positions that offer challenges and opportunities for further development. The research also showed that employees with less work experience emphasize opportunities for professional growth, while more experienced employees value quality of life and long-term benefits. Finally, variations in perception were observed among different positions within the company; managers prioritize stability and quality of life, while specialists focus on professional development and financial incentives.
ATTACHMENT AND FORMING OF IDENTITY
Authors: Marković Emilija , Lazović Nataša , Cvetković Kristina
Published: September 2024

Identity represents the sense of wholeness of one person, sense of continuity in one`s behavior instead of different changes that are occurring inside an individual or around it. The identity consists of cognitive and emotional aspects of an individual and its self-perception about what happens „inside me” and what differ me from other people. Self-perception is developing under the influence of the environment, cultural factors and agencies in the process of socialization and it is the basis of our self-regard as once evaluation of one self. For developing of identity the most important period is adolescence, but we can find the roots in early childhood. For Ericson, in the period before adolescence, in different periods of childhood and early youth a person has to resolve different crises to develop the sense of autonomy, thrust, individuality ect. Globally, the results of identity development can be positive identity outcomes or foreclosure. Those identity development results primarily depend on socio-emotional factors where the great importance belongs to early interaction with caregivers and the mother on the first place. The sense of trust that is developing in the early childhood will result in the secure socio-emotional status and perception of one self and other persons in the environment as positive and reliable. On the other side, early developed sense of insecurity will probably result in the tendency of avoidance. So, consequences of those early interaction will influence characteristic affective style of one person which is related to self-regard and is the part of one’s identity. The aim of this article is to analyze the role of attachment and its importance in forming of an identity which is the basis of our interactions, our feeling of controlling or being controlled, our emotions, attitudes and behavior. Understanding the interplay between these aspects helps us comprehend the complexities of human development.
Forecasting the Epidemic Process of HIV Infection using ARIMA
and Microsoft Excel Tools
Authors: Melnikova Elena N.
Published: September 2024

Relevance: The epidemiological situation on HIV infection in the Russian Federation, in particular in the Tyumen Region, remains very tense. Due to the uncertainty of the situation, modeling and forecasting the evolution of the epidemic occupy a special place in the epidemiology of the disease.
Objective: To forecast the epidemic process for the years 2021 to 2025 based on the results of a retrospective analysis of HIV incidence in the Tyumen Region in 1993–2020 using two different tools (ARIMA and Microsoft Excel) and to compare predictions with the rates actually observed in 2021–2023.
Materials and methods: The study was conducted in March to May 2021 by applying a complex of epidemiological, statistical, and mathematical research methods. For predictive modeling, hierarchical models of the ARIMA family were used with the inclusion of two levels of hierarchy (district and city). Microsoft Excel was used to construct a polynomial trend line.
Results: Based on the output of the ARIMA model, the incidence forecast cartogram was created. According to statistics for the Tyumen Region, HIV incidence rates in the years 2021 and 2022 were 67.9 and 71.4 per 100,000 population, respectively. The predicted rate in 2021 was 52 per 100,000 population (80 % prediction interval (PI): 29 to 76 per 100,000; 95 % PI: 16 to 89 per 100,000 population). When constructing a polynomial trend line (approximation coefficient R² = 0.7497), an increase in HIV incidence was predicted in the region.
Conclusions: The comparison of two predictive methods shows that ARIMA results are more consistent with actual data, which means that the ARIMA model has an advantage in forecasting.
Evaluation of Virucidal Efficacy of Household Chemicals
Authors: Vorontsova Tatyana V. , Eremeeva Natalya I. , Istomina Ludmila I. , Novikov Vyacheslav A. , Demina Yulia V.
Published: September 2024

Introduction: Given the widespread daily use of household chemicals by the population for prevention of the novel coronavirus disease 2019 during the pandemic, it was relevant to establish their efficacy against certain highly contagious viruses.
Materials and methods: In 2022–2023, we tested the virucidal efficacy of 37 household chemical cleaning gels, sprays, solutions based on sodium hypochlorite, organic and inorganic acids, and cationic surfactants intended for decontamination and cleaning of surfaces against poliovirus type 1 (Sabin attenuated LSc/2ab strain), virus titer = 6.8 lg TCID50, and adenovirus type 5, virus titer = 6.5 lg TCID50, according to Clause 3.5 of Russian Guidelines R 4.2.3676–20, Methods of laboratory testing of disinfectants for efficacy and safety.
Study limitations: Hand wash products with disinfection potential were not tested.
Results: Disinfecting agents containing sodium hypochlorite demonstrated efficacy against the study viruses within 5 and 15 minutes, respectively. The time to achieve virucidal efficacy of the samples containing organic and inorganic acids varied from five to 30 minutes. We observed no significant differences (p > 0.05) in the influence of various proportions and percentage concentrations of organic and inorganic acids in the composition of the product samples on the time of manifestation of virucidal efficacy, which suggests potential impact of other ingredients. Surfactants containing 0.264 % to 0.8 % of alkyldimethylbenzylammonium chloride as an active substance showed their virucidal efficacy 30 minutes after wiping, also suggesting the effect of other chemicals added.
Conclusions: We established the virucidal efficacy of household cleaning products, thus confirming that they can be recommended for interruption of the epidemic chain of transmission of viral infections given proper concentrations of the product and exposure time used. Further research is needed to evaluate effects of non-major ingredients of the disinfectants on their virucidal efficacy.