bluuebunny/crossref_metadata_2025 huggingface dataset:
Pekalongan City of Batik: Expression Of Acculturation And Characteristics Diversity
Authors: Yusril Yusril Bariki , Afifah Nur
Published: November 2023

Cultural issues have become a hot topic of discussion in today's society. The usage of batik and the identity should the young people to experience several acculturation problems. This study tries to explain Pekalongan's identity as a city of batik as well as the significance in it. With the use of literature reviews, analyses, and theories supporting acculturation and batik identity, the method of library research is applied to investigate field data. The results revealed that Pekalongan City is a city of batik, that it is actually known as The World City of batik, and that the current batik designs explain what acculturation and diversity of traits entail. This region is home to six distinct types of batik: Batik jlamprang, which conveys the idea that Muslim culture still upholds each other's friendships and lives in harmony; cement batik, which represents a life that can expand, grow, and blossom into a morewealthy life. Bright moon batik This motif's meaning is that everything will always turn out well or perfectly when it should; Seven different types of batik are a representation of the fusion of Javanese and Chinese cultures. The Seven Shapes motif, which means a manifestation of the many abilities of creatures that are united in themselves, demonstrates the wealth of the Pekalongan region. Batik Liong, which means a symbol of power, and Sawat Batik, which means to safeguard. It is clear that the city of Pekalongan has a pluralistic acculturation character based on the local motifs.
DEVELOPMENT TRENDS OF THE INSURANCE MARKET IN TODAY'S ENVIRONMENT
Authors:   National University ", Slobodianiuk Olha ,   Odesa Law Academy"
Published: November 2023

The insurance market in Ukraine is one of the most important components of the country's financial system. In today's conditions, it is under the influence of a number of factors that are leading to a change in its development trends. The article examines the main trends in the development of the insurance market in Ukraine under martial law and post-war recovery. The authors analyze the dynamics of the insurance market, its structure, insurance products and services, insurance companies, and insurance culture in Ukraine. The main trends in the development of the insurance market in Ukraine in today's conditions include: decrease in the size of the insurance market. In 2022, the volume of insurance premiums in Ukraine fell by 30% compared to 2021. This is due to military operations, as well as the economic crisis that arose as a result of the war; change in the structure of the insurance market. In 2022, the share of compulsory insurance in the total volume of the insurance market in Ukraine increased to 60%. This is due to the fact that in the conditions of martial law, the demand for compulsory insurance products, such as life insurance, property insurance, and accident insurance, increased; the growth of the role of digital technologies in the insurance industry. In 2022, insurance companies in Ukraine actively implemented digital technologies. This allowed them to improve the efficiency of their activities and ensure the availability of insurance services to the population. The growth of the role of insurance companies in ensuring financial stability. In 2022, insurance companies in Ukraine played an important role in ensuring the financial stability of the country. They paid insurance claims to those affected by the war, and also provided financial assistance to businesses. Conclusions: the insurance market in Ukraine has significant potential for further development. To do this, it is necessary to create favorable conditions for the activities of insurance companies, increase the level of insurance culture of the population, and ensure the stability of macroeconomic indicators.
Consideration for Connection between Concrete and Abstract of Living System
Authors: Nishida Y
Published: November 2023

Living systems are established by the coordination of diverse systems in the environment, are responsive to change, and are stable over time. Many studies and ideas have been proposed on the mechanisms and general laws of living systems from the viewpoints of evolutionary biology, systems biology, and chaos theory. The mechanisms of evolution and coordination of living systems are also related to physics, probability theory, statistics, organization theory, and information science because they are the mechanisms of phenomena and organizations. In this study, we propose several hypotheses to explain the processes of organization and evolution of individual organisms and, in conclusion, we propose a hypothesis to generalize and describe the universal nature of living systems.
A Translation and Analysis of ʾAbd al-Jabbār Ibn Ḥamdīs’ Poem No. 110: “Qaḍat al-Nafs”
Authors: Shuqair Khaled M.
Published: November 2023

In this paper, I undertake a complete translation of Ibn Ḥamdīs’ poem No.110 “Qaḍat al-Nafs” and provide a structural analysis in order to demonstrate that the poem in its entirety is structured through a succession of related metaphors that lends unity and organization to the speaker’s experience.  Though Ibn Ḥamdīs is committed to the canon of classical Arabic poetry in the division of the poem into three canonical segments of the classical qasīda (physical decay and the loss of youth, the wine song and the nostalgic feelings for a lost homeland), I argue that these segments are not loosely structured but built upon a succession of related and resonating metaphors that lends unity and coherence to the speaker’s experience.  The poem can also be read as an autobiographical document in which Ibn Ḥamdīs records his own tragedy as an exile and the tragedy of Muslim Sicily and Arabic culture. Having led a very active life in his youth, the persona is now old, frequenting taverns and indulging himself in merry making in an attempt to recapture youth.  However, the speaker’s attempt is overwhelmed by the tragic awareness that his action is futile; youth cannot be regained.  This realization is intensified by the feeling that Sicily, the speaker’s birthplace and the setting of his youth, is also lost forever.  Regaining his “paradise” is as impossible as regaining his youth.  Old age and the great sense of loss make him turn to God with a penitent attitude.
Gambaran Karakteristik dan Pengetahuan Ibu Mengenai Pemberian Imunisasi Dasae Lengkap Pada Bayi Usia 0-12 Bulan di Wilayah Kerja Puskesmas Medono Koya Pekalongan
Authors: Wahani Salisa Tara , Mustikawati Neti
Published: November 2023

ABSTRACT The coverage of complete basic immunization in Pekalongan City in 2021 was 86.06% out of 5110. This number did not meet the 2021 Strategic Plan target of 93.6%. This study aims to describe maternal knowledge regarding the administration of complete basic immunization for infants aged 0-12 months. This quantitative descriptive research design involved 45 mothers with infants aged 1 month in the working area of Medono Community Health Center. Total sampling technique was used. Data analysis of characteristics was conducted using univariate analysis, while knowledge was analysed using frequency and percentage. The results showed that the mean age of the respondents was 30 years, and they had an average of 2 children. 23 respondents (51.1%) had completed high school education, and 27 (60%) were not employed. 24 respondents (53.3%) had previous experience. All 45 respondents (100%) were Muslims and of Javanese ethnicity. The description of maternal knowledge regarding the administration of complete basic immunization for infants aged 0-12 months indicated that the majority of respondents had a category of insufficient knowledge (60%), a moderate knowledge category had 15 respondents (33.3%), and only 3 respondents (6.7%) had a good knowledge category. The majority of respondents had insufficient knowledge, indicating aneed for education using media-printed, posters, and brochures.  Keywords: Demographic Characteristics, Immunization, Knowledge  ABSTRAK Cakupan imunisasi dasar lengkap di Kota Pekalongan tahun 2021 86,06% dari 5110. Angkanya belum memenuhi target Renstra tahun 2021 yaitu 93,6%. Penelitian ini bertujuan untuk mendeskripsikan gambaran pengetahuan ibu mengenai pemberian imunisasi dasar lengkap pada bayi usia 0-12. Desain penelitian kuantitatif deskriptif dengan 45 ibu yang mempunyai bayi usia 1 bulan di wilayah kerja Puskesmas Medono. Teknik total sampling. Analisa data karakteristik menggunakan univariat dan pengetahuan dianalisa dengan frekuensi dan presentase. Hasil penelitian karakteristik responden rata rata berusia 30 tahun dan mempunyai 2 anak, responden berpendidikan SMA/SMK 23 (51,1%), 27 (60%) tidak bekerja, responden yang berpengalaman 24 (53,3%), seluruh responden 45 (100%) beragama islam dan suku jawa. Gambaran pengetahuan ibu mengenai pemberian imunisasi dasar lengkap pada bayi usia 0-12 bulan sebagian besar responden kategori pengetahuan kurang 27 (60%), di kategori pengetahuan yang cukup ada 15 (33,3%), dan kategori pengetahuan baik hanya 3 (6,7%). Sebagian besar responden memiliki pengetahuan yang kurang sehingga perlu dilakukan penyuluhan dengan menggunakan media cetak, poster, dan brosur. Kata Kunci: Karakteristik Demografi, Pengetahuan, Imunisasi
СТРАТЕГІЧНІ КОМУНІКАЦІЇ У ПОСТСУЧАСНИХ ДЕМОКРАТІЯХ
Authors: Осьодло В. , Будагьянц Л.
Published: November 2023

Державні органи відповідають за стратегічні комунікації й стратегічні наративи, приймаючі їх інструментально та операціонально. Однак смислове ядро стратегічних наративів зароджується поза межами їх у життєвому світі мережевого суспільства. Побудова стратегічних комунікацій як відкритої системи надає стійкості та сталого розвитку у мережево-цифровому соціальному середовищі, особливо під час війни.
ВКЛАД УКРАЇНСЬКИХ ВЧЕНИХ У ДОСЛІДЖЕННЯ ПРОБЛЕМ ПСИХОЛОГІЧНОГО І ПРОФЕСІЙНОГО ЗДОРОВ’Я ФАХІВЦІВ
Authors: Кривда К.
Published: November 2023

Суттєвим доробком українських вчених у проблему вивчення професійного здоров’я фахівців є визначення особливостей психологічного забезпечення професійного здоров’я в умовах пандемії та війни. Науковцями представлено методи психодіагностики, психологічні технології підтримки, збереження і відновлення професійного здоров’я фахівців та можливості особистісного зростання на різних етапах професіогенезу.
Evaluación de la concentración de nitratos y fosfatos por Chlorella vulgaris en aguas superficiales en el tramo Salguero del río Cesar
Authors: Téllez Luna María Isabel , Ospino Jiménez Jean Carlos
Published: November 2023

Los sistemas biológicos como las algas son implementados como herramientas de biorremediación en fuentes de agua con altas concentraciones de nitratos y fosfatos. Desde una perspectiva económica, el tratamiento de agua mediante microalgas es una opción rentable, renovable y fácil de fabricar para la eliminación de contaminantes en los efluentes. Por lo tanto, el objetivo principal de este artículo es evaluar la eliminación de nitratos y fosfatos de las aguas postratamiento de la Planta de Tratamiento de Aguas Residuales de Valledupar-Cesar con la utilización de Chlorella vulgaris. Se medirán los niveles iniciales de nitratos y fosfatos en el agua tratada, se evaluará la producción de biomasa y se cuantificará la eliminación de nitratos y fosfatos. Se espera que la utilización de microalgas sea una alternativa efectiva para la eliminación de nitratos y fosfatos en los efluentes de la Planta de Tratamiento de Aguas Residuales.
Clinical Profile and outcome of Dengue Fever in Under 5 Children Admitted at a Tertiary Care Hospital, Dhaka
Authors: Ahmed Tasnima , Nahar Jebun , Mohsin Fauzia , Islam Nasreen , Jashim Sabrina
Published: November 2023

Background: Dengue has become a major public health problem in Bangladesh with gradually increasing infectivity and severity. Most vulnerable population are children especially children below 5 years of age. However, data regarding dengue among this age group is limited. The objectives of this study were to see the clinical and laboratory profile of dengue fever (DF) in children below 5 years of age and their outcome.
Methods: This cross – sectional observational study was carried out in the department of Paediatrics, BIRDEM General Hospital from May 2023 to September 2023. One hundred eighty nine confirmed dengue cases were enrolled in the study. Their clinical profile and laboratory findings including haemoglobin (Hb%), haematocrit (Hct), total count of white blood cells (TC), platelet count (PC), serum alanine aminotransferase (S. ALT), serum aspartate aminotransaminase (S. AST), prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), serum calcium and serum sodium level were documented and analyzed.
Results: Among 189 children 57(30.1%) were infants and 132(69.8%) patients were aged 1 to 5 years. Depending upon the severity of dengue 98(51.8%) were classical dengue fever, 65(34.3%) and 14(7.4%) presented with dengue shock syndrome (DSS) and dengue heamorrhagic fever (DHF) respectively. Fever was present in all children, other common features were vomiting (34.9%), cough (25.9%), dehydration (26.9%), pleural effusion (34.3%), ascites (23.2%) and skin rash (18.5%). Shock were present in 41.1% cases. Warning signs like restlessness, lethargy, altered level of consciousness, convulsion was present in 16.4%, 9.5%, 2.6% and 11.6% respectively. All the children were improved and discharged.
Conclusion: In this study dengue presented classically in most of the children. Dengue shock syndrome and dengue haemorrhagic fever were below 10%. The outcome was excellent with no modality. Early reporting to hospital appeared important.
J Bangladesh Coll Phys Surg 2023; 41: 25-28
Классификация и анализ основных работ при строительстве атомных электростанций
Authors: ВОРОНКОВ Иван Евгеньевич , ОСТРОВСКИЙ Роман Вадимович
Published: November 2023

Один из важнейших экономических индикаторов успешного строительства - продолжительность возведения объекта, что особенно важно при рассмотрении сроков реализации проектов крупных атомных электростанций. Сроки строительства отражаются в графиках различного уровня - от межправительственных соглашений до детальных временных графиков. В статье приведено распределение проектных графиков сооружения атомных электростанций по уровням и функциям в области управления сроками. В рамках исследования проанализированы детальные графики, включающие в себя десятки тысяч работ, по нескольким наиболее активным международным строительным площадкам на предмет классификации основных типов работ при строительстве атомных электростанций. Для каждого типа работ рассчитана вероятность превышения фактической продолжительности относительно плановой, а также ее среднее значение. Исследованиями установлено, какие работы чаще других составляют критический путь проекта и оказывают на него наибольшее влияние. В целях страхования рисков срыва сроков работ предлагается использование собранных и обработанных статистических данных в качестве исходных для вероятностного расчета графиков производства работ и дальнейшего утверждения их заказчиком, генподрядчиком и субподрядными организациями.
Демонтаж зданий и сооружений с глубокой переработкой продуктов сноса
Authors: КОДЫШ Эмиль Наумович
Published: November 2023

Рассмотрены актуальные вопросы развития технологий демонтажных работ, современные законодательные и нормативные отраслевые документы. Анализ применяемых методов демонтажа показал необходимость разработки технологических рекомендательных документов - пособий и методических рекомендаций, а также подготовки высококвалифицированных кадров, способных управлять сложным, в том числе роботизированным оборудованием. Представлены примеры организационной работы Национальной ассоциации демонтажных организаций - участие в разработке нормативных документов, проведении мероприятия, направленного на демонстрацию процесса работы демонтажного оборудования. Особо актуальным, многоплановым и сложным является вопрос переработки отходов демонтажа (сноса) зданий и сооружений. Приведены данные объема отходов в нашей стране и положение с их переработкой в других странах. Кратко изложено прогрессивное технологическое направление переработки самого массового продукта демонтажа - бетона. Перечислены меры, предпринимаемые по резкому сокращению объема неперерабатываемых отходов демонтажа. Даны рекомендации по совершенствованию демонтажных работ и увеличению объемов перерабатываемых отходов.
Democratic Parenting Patterns in Fostering Student Learning Discipline at SDN Tengaran 2
Authors: Rochman Zainur , Raharja Hawwin Fitra
Published: November 2023

This research is motivated by the lack of student learning discipline at SDN Tengaran 2. The objectives to be achieved in this study are to describe the form of student learning phenomena, describe how to grow student discipline and describe democratic parenting patterns that can foster student learning discipline at SDN Tengaran 2 Peterongan District, Jombang Regency. This study uses a qualitative approach with a qualitative descriptive type of research. The subjects of this study were parents, education staff and students. The data collection method used is the method of observation, interviews and documentation. The validity of the data was obtained by using source triangulation, time triangulation and technical triangulation. The results showed that; 1) The form of student learning discipline at SDN Tengaran 2 can be seen from 4 aspects, namely; a) obeying learning activities at school, b) obeying regulations, c) carrying out their duties and d) learning discipline. 2) How to cultivate student learning discipline at SDN Tengaran 2 by providing direct examples. 3) Democratic parenting is applied in fostering student learning discipline by setting a good example before ordering children to be disciplined, giving rewards and punishments so that children are more disciplined and motivated and familiarizing children from an early age to always behave in a disciplined manner by prioritizing common interests and considering all matters. something without imposing the will of parents.
Knowledge of Feeding Practices and the Development of Stunting Toddlers Ages 24-59 Month
Authors: Mellyani Jhein , Ansar  , Kusumawati Dwi Erma
Published: November 2023

Mother's knowledge about feeding and developing stunting toddlers in Sigi Regency is not widely known. The purpose of this study was to determine the mother's knowledge about child feeding and the development of stunting toddlers aged 24-59 months in the working area of ​​the Kamaipura Public Health Center, Tanambulava District. This research is descriptive research in the form of a survey, conducted in April - May 2021, in five villages located in Tanambulava District. The population in this study were all stunting toddlers aged 24-59 months totaling 45 people. The sampling technique used was non-probability sampling, by directly interviewing mothers of children under five about the knowledge of child feeding using a questionnaire and measuring the development of stunting under five with a pre-screening development questionnaire according to the age group. Data analysis used univariate analysis. The results showed that the mother's knowledge about child feeding was still not good at 57.8%. Meanwhile, the results of measuring the development of stunting toddlers are in the dubious category of 62.2%. Based on the results of this study, it can be concluded that the knowledge possessed by mothers of toddlers about child feeding is classified as poor, and the development of stunting toddlers is categorized as dubious. Suggestions are expected for nutritionists or midwives to provide feeding practices counseling to mothers of toddlers and to conduct developmental counseling to mothers of stunting toddlers.
Prebiotik dan Dermatitis Atopik pada Anak
Authors: Nuur Al Azizah Fauziyyah
Published: November 2023

Dermatitis atopik adalah kondisi kulit berupa inflamasi kronis yang umum ditandai dengan gatal berulang yang parah. Gejala yang muncul termasuk kulit kering, lesi eksim, eritema (kemerahan), edema, erosi, oozing dan pengerasan kulit, yang bervariasi menurut kronisitas lesi dan usia pasien yang terkena Dermatitis atopik. Individu dengan Dermatitis atopik dalam tingkat sedang hingga berat juga dapat menunjukkan hiperpigmentasi retikulat yang didapat pada leher (juga disebut 'leher kotor') yang dihasilkan dari kombinasi hiperpigmentasi pasca inflamasi dan gesekan. Pruritus atau sensasi tidak menyenangkan pada kulit yang memicu rasa gatal sering menyebabkan trauma kulit, ketidaknyamanan, dan gangguan tidur. Memperbaiki status gizi, pencernaan nutrisi, respon imun spesifik dan non spesifik, efek menguntungkan pada saluran pencernaan dan kulit, adalah upaya untuk mendukung penggunaan pra dan probiotik pada pasien dengan Dermatitis Atopik. Namun, tidak ada cukup data dalam literatur untuk menjawab pertanyaan mengenai dosis optimal, waktu optimal untuk memulai pengobatan dan durasi yang diperlukan untuk menunjukkan efek yang menguntungkan; penggunaan probiotik yang dipersonalisasi menurut dysbiosis kolon dapat dikaitkan dengan hasil terbaik. Tinjauan pustaka ini mengkaji Prebiotik dan Dermatitis Atopik pada Anak.
Pengaruh Penyuluhan Gizi Terhadap Pengetahuan Anemia Dan Kekurangan Energi Kronik Siswi Madrasah Tsanawiyah Darul Hikmah Poniang
Authors: Sari Diesna , Kalsum Ummu , Mubarak Muhammad Hosni
Published: November 2023

ABSTRAK
Latar  Belakang: Masalah gizi yang rentan terjadi pada kelompok remaja adalah anemia dan KEK. Pengetahuan seseorang akan sangat berpengaruh terhadap sikap dan perilaku dalam pemilihan makanan. Tujuan: Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian penyuluhan terhadap pengetahuan anemia dan kekurangan energi kronik (KEK) pada Siswi MTS Darul Hikmah Poniang. Metode: Jenis penelitian adalah quasi eksperimental dengan desain one group pre-post test. Populasi penelitian yaitu seluruh siswi di Mts Darul Hikmah Poniang. Penentuan sampel menggunakan teknik pengambilan sampel secara acak dengan  kriteria  inklusi  yaitu  remaja  putri  berumur  12-17  tahun,  sudah menstruasi,  dan  bersedia menjadi  subjek   penelitian  dengan  menandatangani informed  consent berjumlah sebanyak 34 orang siswi. Data pengetahuan dikumpulkan dengan membagikan lembar kuesioner yang telah disediakan. Analisis data menggunakan analisis univariat dan bivariat. Hasil: Terjadi peningkatan persentase jumlah anak yang memiliki kategori tingkat pengetahuan yang cukup terkait anemia yakni dari 23,53 % menjadi 50%, begitupun pada katergori tingkat pengetahuan yang cukup terkait KEK yakni dari 26,47% menjadi 55,89 %. Hasil uji menunjukkan ada perbedaan bermakna secara statistic dengan menggunakan uji Wilcoxon yaitu (p<0,05) antara kedua variable yakni hasil pengetahuan tentang anemia dan KEK yang signifikan antara sebelum dan sesudah diberikan intervensi berupa penyuluhan gizi. Nilai P pada analisis uji pada pengetahuan anemia menunjukkan angka p = 0,026. Dan Nilai P pada tabel analisis uji pengetahuan KEK menunjukkan angka p = 0,001. Kesimpulan: Ada pengaruh perbedaan hasil pengetahuan tentang anemia dan KEK yang signifikan antara sebelum dan sesudah diberikan intervensi berupa penyuluhan gizi pada remaja putri
Hubungan Pengetahuan Dan Prilaku Risiko Obesitas Terhadap Kejadian Obesitas Remaja Pada Masa Pandemi Covid 19
Authors: Wijianto Wijianto , Candriasih Putu , Sukmawati  , Nurarifah  , Hafid Fahmi
Published: November 2023

Prevalesnis status gizi obesitas pada remaja di Indonesia dari tahun ketahun mengalami peningkatan. Hasil Riset Kesehatan Dasat tahun 2013 tercatat prevalesni obesitas pada remaja umur 16-18 tahun sebesar 1.6% dan tahun 2018 menjadi 4% dari jumlah penduduk. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan dan perilaku risiko obesitas terhadap kejadian obesitas remaja pada masa Pandemi Covid 19 di kabupaten Banggai. Metode penelitian yang digunakan dalah penelitian survei analitik dengan desain penelitian cros sectional study. Jumlah sampel pada penelitian ini adalah 202 siswa kelas X yang berumur 14-17 tahun. Teknik pengambilan sampel dilakukan dengan cluster sampling. Analisis statistik yang digunakan adalah Chi Square. Hasil penelitian didapatkan bahwa prevalensi obesitas remaja di kabupaten Banggai sebesar 13.4%, sebagain besar remaja (52%) telah memiliki pengetahuan yang baik tentang obesitas, dan sebagian besar (55.2%) remaja memiki perilaku yang kurang baik terhadap obesitas. Hasil uji ststatistik variabel pengetahuan dan perilaku tidak mempunyai hubungan bermakna dengan obesitas remaja (p > 0.05). perlu adanya edukasi kepada remaja untuk menjaga dan mencegah terjadinya kelebuhan berat badan dengan peningkatan pengetahuan dan perilaku yang baik terhadap obesitas
Pengaruh Media Komik Dan Poster Terhadap Pengetahuan Gizi Seimbang Anak Sekolah
Authors: Kaluku Khartini
Published: November 2023

Background: Due to a lack of awareness about balanced nutrition requirements, school-age children are currently struggling with a variety of nutritional issues, including undernutrition and excess nutrition. The purpose of this study was to compare the impact of comic books and posters on children's knowledge of a balanced diet. Methods: This type of research is a quasi-experimental design with a pre-post test with control. The research location was at the Ambon City Orphanage with 60 school children aged 10-12 years as subjects. The independent variable is the use of comics and posters in balanced nutrition counseling, while the dependent variable is children's knowledge. At the beginning and end of the study, children's knowledge was measured by a questionnaire. Data analysis used paired sample test and independent samples T-test. The results showed that there was a significant increase in knowledge of balanced nutrition in orphanage children before and after being given comic media and posters with a p-value <0.05. Counseling with poster media is more effective in increasing nutrition knowledge than comic media.
Does it make any sense to fit cochlear implants according to the anatomy-based fitting? Our experience with the first series of patients
Authors: Lassaletta Luis , Calvino Miryam , Sánchez-Cuadrado Isabel , Gavilán Javier
Published: November 2023

Introduction

Personalization of treatment is a growing trend in various fields of medicine, and this includes cochlear implantation. Both the precise choice of the length and shape of the electrode array to fit a particular cochlear anatomy, as well as an individualized fitting setting have been suggested to improve hearing outcomes with a cochlear implant (CI). The aim of this study was to compare anatomy-based fitting (ABF) vs. default fitting in terms of frequency-to-place mismatch, speech discrimination, and subjective outcomes in MED-EL CI users.

Methods

Eight adult CI users implanted with a Synchrony ST Flex28 were enrolled prospectively. Insertion depth and tonotopic distribution of each electrode was calculated using the Otoplan software. The mismatch was calculated for each fitting strategy relative to the electrodes' tonotopic place-frequency. Speech tests and patient preference was evaluated after 9 months with ABF and 1 month after default fitting.

Results

Median angular insertion of the most apical active electrode was 594° (interquartile range 143°). ABF showed lower mismatches than default fitting in all patients (p ≤ 0.01). Mean speech discrimination score with ABF and default fitting was 73 ± 11% and 72 ± 16%, respectively (p = 0.672). Mean speech reception threshold with ABF and default fitting was 3.6 ± 3.4 dB and 4.2 ± 5.0 dB, respectively (p = 0.401). All patients except one preferred ABF when they were asked about their preference.

Conclusion

ABF maps have a lower frequency-to-place mismatch than default fitting maps. In spite of similar hearing outcomes most patients prefer ABF. More data are necessary to corroborate the benefit of the ABF over default fitting in speech and subjective tests.
A concise overview of advancements in ultrasensitive biosensor development
Authors: Shahid Ammara , Nazir Fazila , Khan Muhammad Jawad , Sabahat Sana , Naeem Aisha
Published: November 2023

Electrochemical biosensing has evolved as a diverse and potent method for detecting and analyzing biological entities ranging from tiny molecules to large macromolecules. Electrochemical biosensors are a desirable option in a variety of industries, including healthcare, environmental monitoring, and food safety, due to significant advancements in sensitivity, selectivity, and portability brought about by the integration of electrochemical techniques with nanomaterials, bio-recognition components, and microfluidics. In this review, we discussed the realm of electrochemical sensors, investigating and contrasting the diverse strategies that have been harnessed to push the boundaries of the limit of detection and achieve miniaturization. Furthermore, we assessed distinct electrochemical sensing methods employed in detection such as potentiometers, amperometers, conductometers, colorimeters, transistors, and electrical impedance spectroscopy to gauge their performance in various contexts. This article offers a panoramic view of strategies aimed at augmenting the limit of detection (LOD) of electrochemical sensors. The role of nanomaterials in shaping the capabilities of these sensors is examined in detail, accompanied by insights into the chemical modifications that enhance their functionality. Furthermore, our work not only offers a comprehensive strategic framework but also delineates the advanced methodologies employed in the development of electrochemical biosensors. This equips researchers with the knowledge required to develop more accurate and efficient detection technologies.
Experimental benchmark control problem for multi-axial real-time hybrid simulation
Authors: Condori Uribe Johnny W. , Salmeron Manuel , Patino Edwin , Montoya Herta , Dyke Shirley J. , Silva Christian E. , Maghareh Amin , Najarian Mehdi , Montoya Arturo
Published: November 2023

Advancing RTHS methods to readily handle multi-dimensional problems has great potential for enabling more advanced testing and synergistically using existing laboratory facilities that have the capacity for such experimentation. However, the high internal coupling between hydraulics actuators and the nonlinear kinematics escalates the complexity of actuator control and boundary condition tracking. To enable researchers in the RTHS community to develop and compare advanced control algorithms, this paper proposes a benchmark control problem for a multi-axial real-time hybrid simulation (maRTHS) and presents its definition and implementation on a steel frame excited by seismic loads at the base. The benchmark problem enables the development and validation of control techniques for tracking both translation and rotation degrees of freedom of a plant that consists of a steel frame, two hydraulic actuators, and a steel coupler with high stiffness that couples the axial displacements of the hydraulic actuators resulting in the required motion of the frame node. In this investigation, the different components of this benchmark were developed, tested, and a set of maRTHS were conducted to demonstrate its feasibility in order to provide a realistic virtual platform. To offer flexibility in the control design process, experimental data for identification purposes, finite element models for the reference structure, numerical, and physical substructure, and plant models with model uncertainties are provided. Also, a sample example of an RTHS design based on a linear quadratic Gaussian controller is included as part of a computational code package, which facilitates the exploration of the tradeoff between robustness and performance of tracking control designs. The goals of this benchmark are to: extend existing control or develop new control techniques; provide a computational tool for investigation of the challenging aspects of maRTHS; encourage a transition to multiple actuator RTHS scenarios; and make available a challenging problem for new researchers to investigate maRTHS approaches. We believe that this benchmark problem will encourage the advancing of the next-generation of controllers for more realistic RTHS methods.
Endobronchial optical coherence tomography helps to estimate the cartilage damage of the central airway in TBTB patients
Authors: Zong Kaican , Liu Bin , Li Shiying , Li Yishi , Guo Shuliang
Published: November 2023

Purpose

At present, there are few examination methods used to evaluate tracheobronchial cartilage damage. In our study, we explored whether endobronchial optical coherence tomography (EB-OCT) can be used to estimate central airway cartilage damage in tracheobronchial tuberculosis (TBTB) patients.

Methods

In our study, we used the OCTICS Imaging system to perform EB-OCT scanning for TBTB patients. The thickness of the central airway wall and cartilage was measured by the OCTICS software system workstation.

Results

There were 102 TBTB patients included in our study cohort. Their EB-OCT images of the central airway cartilage showed that abnormal cartilage manifests as thinning of the cartilage, cartilage damage, cartilage destruction, and even cartilage deficiency. The cartilage morphology becomes irregular and discontinuous. Some parts of the cartilage become brighter in grayscale. The intima of the cartilage is thickened and discontinuous, and the boundary with submucosa and mucosa is unclear.

Conclusion

Our study conducted EB-OCT examination of the central airway cartilage of TBTB patients in vivo for the first time. EB-OCT helps to estimate the cartilage damage of the central airway in TBTB patients to some extent.
Reintroducing bison to Banff National Park – an ecocultural case study
Authors: Heuer Karsten , Farr Jonathan , Littlebear Leroy , Hebblewhite Mark
Published: November 2023

The reintroduction of extirpated species is a frequent tactic in rewilding projects because of the functional role species play in maintaining ecosystem health. Despite their potential to benefit both ecosystems and society, however, most well-known species reintroductions have adopted an eco-centric, “nature-in-people-out” approach. Rewilding theory and practitioners acknowledge that ignoring the role Indigenous people did and might once again play in shaping the distribution, abundance, movements, behavior, and health of wild species and ecosystems, is limiting. In this case study, we describe the technical steps we took and how Indigenous knowledge, ceremony, and cultural monitoring were woven into the recent reintroduction of plains bison to Canada’s Banff National Park. Six years later, the reintroduced bison herd has grown from 16 to >100 animals, ranges mostly within 30 km of the release site, and, if current growth continues, will likely be managed with Indigenous harvesting. Transboundary bison policy differences are shifting and may lead to bison being more sustainable. The ecocultural approach, therefore, has increased the resilience of our rewilding project.
What affects second language vocabulary learning? Evidence from multivariate analysis
Authors: Sun Danning , Chen Zihan , Zhu Shanhua
Published: November 2023

Introduction

Vocabulary acquisition is crucial in second language (L2) learning and can be affected by multi-variables. The fact that all these variables have typically been investigated separately (or, at best, in pairs) potentially obscures important interactions between them. This study comprehensively examines the intricate factors affecting vocabulary knowledge among Chinese learners studying English as a foreign language (EFL).

Methods

We conducted an investigation involving 200 Chinese EFL learners to identify the relationships between L2 proficiency, vocabulary learning strategies, age of acquisition (AoA), classroom exposure, and their relationships and predictive power on L2 vocabulary breadth and vocabulary depth.

Results

L2 proficiency emerged as the most robust predictor of vocabulary knowledge, closely trailed by vocabulary learning strategies, AoA, and classroom exposure. Notably, the use of metacognitive learning strategies such as self-regulated and self-aware learning, was found to be significant. Earlier L2 exposure resulted in a more sufficient vocabulary knowledge. However, the conventional belief that longer classroom sessions lead to enhanced vocabulary knowledge was challenged.

Discussion

Our findings suggest the interconnectedness between L2 proficiency and L2 vocabulary knowledge. The investigation highlights the need for increased cognitive involvement and self-discipline in L2 vocabulary learning. This study also emphasizes the necessity to maximize the efficacy of classroom sessions, together with the benefits for an earlier age of L2 acquisition. Guidance for L2 researchers and instructors in second language vocabulary acquisition is offered.
Effect of collagen endometrial patch loaded with adipose-derived mesenchymal stem cells on endometrial regeneration in rats with a thin endometrium
Authors: Hong Juyeon , Ahn Hyojin , Moon Soo Young , Kang Hyo Jin , Yi Kyong Wook
Published: November 2023

Background

This study aimed to investigate the effects of a collagen endometrial patch (EM patch) loaded with adipose-derived mesenchymal stem cells (ADSCs) on endometrial regeneration in a rat model with thin endometrium.

Materials and methods

Thin endometrium was induced in female rats and divided into treatment groups as outlined: control, group 1(G1), local injection of ADSCs into the uterus, group 2 (G2), an EM patch without ADSCs, group 3 (G3), and an EM patch loaded with ADSCs, group 4 (G4). The rats were euthanized at either two weeks or four weeks after modeling and treatment followed by histological and biochemical analyses to examine the regenerative effects on the injured endometrium.

Results

Transplantation of the ADSC-loaded EM patch significantly promoted endometrial proliferation and increased the luminal epithelial area. Two weeks after treatment, the mean number of von Villebrand factor (vWF)+ or cluster of differentiation (CD) 31+-stained blood vessels was significantly higher in G4 than in G1 and G2. The mRNA and protein expression levels of TGF-β and FGF2 were significantly upregulated in G4 compared to those in the control. G4 exhibited significantly increased LIF mRNA levels and immunoreactivity compared with the other groups at both two weeks and four weeks after treatment. Cell tracking after ADSCs treatment revealed the presence of a substantial number of ADSCs grafted in the uterine tissues of G4, whereas a low number of ADSCs that were focally clustered were present in G2.

Conclusion

Transplantation of EM patches loaded with ADSCs resulted in the histological and biochemical restoration of an injured endometrium. The strategic integration of EM patches and ADSCs holds significant promise as an innovative therapeutic approach for effectively treating impaired endometrial conditions.
Relationship between advanced lung cancer inflammation index and long-term all-cause, cardiovascular, and cancer mortality among type 2 diabetes mellitus patients: NHANES, 1999–2018
Authors: Chen Yaying , Guan Mengqian , Wang Ruiqi , Wang Xuewen
Published: November 2023

Background

Type 2 diabetes mellitus (T2DM) was a major global health threat. As a chronic low-grade inflammatory disease, the prognosis of diabetes was associated with inflammation. The advanced lung cancer inflammation index (ALI) served as a comprehensive index to assess inflammation. This study aimed to estimate the association between ALI and all-cause, cardiovascular disease (CVD), and cancer mortality in T2DM patients.

Methods

We extracted cohort data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999-2018 for analysis. The weighted Kaplan-Meier analysis and multivariate-adjusted Cox analysis were utilized to evaluate the relationship between ALI and all-cause, CVD, and cancer mortality in T2DM patients. Restricted cubic spline (RCS) analysis was employed to assess their non-linear relationship. Stratified analysis and interaction analysis were conducted to enhance the robustness of the results.

Results

The study incorporated a total of 3,888 patients. An increase in ALI was associated with a reduced risk of all-cause and CVD mortality in T2DM patients, but not related to cancer mortality. There were J-shaped and L-shaped non-linear relationships between ALI and all-cause, CVD mortality in T2DM patients, respectively. The inflection points were 90.20 and 93.06, respectively. For values below the inflection point, every 10U increase in ALI, both all-cause and CVD mortality risk decreased by 9%. Beyond the inflection point, all-cause mortality rose by 3%, while CVD mortality remained unaffected. Gender-stratified RCS analysis indicated a linear negative relationship between CVD mortality and ALI in female T2DM patients, whereas the trend in males aligned with the overall population.

Conclusion

Our research initially identified a significant correlation between increased ALI levels with decreased all-cause and CVD mortality in T2DM patients. There were J-shaped and L-shaped non-linear relationships between ALI and all-cause, CVD mortality in T2DM patients, respectively. For female patients, there was a linear negative relation between CVD mortality and ALI, whereas the trend in males aligned with the overall population. These findings suggested that maintaining ALI (for example, control body weight and keep albumin in the normal range) within a certain range in the clinical settings was crucial for improving all-cause and CVD mortality in T2DM patients.
Potential of hydrogel treatment in forest regeneration: impact on growth and vitality of Central European tree species
Authors: Tomášková Ivana , Resnerová Karolina , Trombik Jiří , Bláha Jaromír , Pastierovič Filip , Macků Jan
Published: November 2023

Introduction

Drought negatively affects the growth and yield of plants. Several measures have been employed to improve the drought tolerance of plants, including the application of superabsorbent hydrogel (SAH) to soil. However, studies on the effect of SAH on trees in Central Europe, which has a temperate climate, are scarce.

Methods

Here, the effects of SAH treatment on the cultivation of four key tree species in Central European forest ecosystems—European beech, sessile oak, Scots pine, and Norway spruce—were evaluated. Field and greenhouse experiments were conducted; the greenhouse conditions served as the reference for the absence of water stress.

Results and Discussion

SAH treatment reduced seedling mortality by 1%–9% in the field experiment. The morphological parameters of the control and SAH-treated seedlings did not significantly differ. Among the tree species, oak seedlings exhibited a positive response to SAH treatment. Spruce, pine, and beech did not respond to SAH treatment; the proline content of SAH-treated conifer leaves was three times higher than that of oak leaves but still very low, revealing no drought stress. The results highlight the significance of employing an individual approach in the application of SAH in forestry, rather than relying on generic measures.
Genome-wide identification and characterization of tissue specific long non-coding RNAs and circular RNAs in common carp (Cyprinus carpio L.)
Authors: Das Jutan , Kumar Baibhav , Saha Bibek , Jaiswal Sarika , Iquebal Mir Asif , Angadi U. B. , Kumar Dinesh
Published: November 2023

Cyprinus carpio is regarded as a substitute vertebrate fish model for zebrafish. A varied category of non-coding RNAs is comprised of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs). These ncRNAs were once considered non-functional “junk DNA” but research now shows they play important roles in gene expression regulation, chromatin modification, and epigenetic regulation. The systemic tissue-specific research of the lncRNAs and circRNAs of C. carpio is yet unexplored. A total of 468 raw RNA-Seq dataset across 28 distinct tissues from different varieties of common carp retrieved from public domain were pre-processing, mapped and assembled for lncRNA identification/ classification using various bioinformatics tools. A total of 33,990 lncRNAs were identified along with revelation of 9 miRNAs having 19 unique lncRNAs acting as their precursors. Additionally, 2,837 miRNAs were found to target 4,782 distinct lncRNAs in the lncRNA-miRNA-mRNA interaction network analysis, which resulted in the involvement of 3,718 mRNAs in common carp. A total of 22,854 circRNAs were identified tissue-wise across all the 28 tissues. Moreover, the examination of the circRNA-miRNA-mRNA interaction network revealed that 15,731 circRNAs were targeted by 5,906 distinct miRNAs, which in turn targeted 4,524 mRNAs in common carp. Significant signaling pathways like necroptosis, NOD-like receptor signaling pathway, hypertrophic cardiomyopathy, small cell lung cancer, MAPK signaling pathway, etc. were identified using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. The web resource of common carp ncRNAs, named CCncRNAdb and available at http://backlin.cabgrid.res.in/ccncrnadb/ gives a comprehensive information about common carp lncRNAs, circRNAs, and ceRNAs interactions, which can aid in investigating their functional roles for its management.
Neutrophil heterogeneity and aging: implications for COVID-19 and wound healing
Authors: Liu Yi , Xiang Changlan , Que Zhenni , Li Chenglong , Wang Wen , Yin Lijuan , Chu Chenyu , Zhou Yin
Published: November 2023

Neutrophils play a critical role in the immune response to infection and tissue injury. However, recent studies have shown that neutrophils are a heterogeneous population with distinct subtypes that differ in their functional properties. Moreover, aging can alter neutrophil function and exacerbate immune dysregulation. In this review, we discuss the concept of neutrophil heterogeneity and how it may be affected by aging. We then examine the implications of neutrophil heterogeneity and aging for COVID-19 pathogenesis and wound healing. Specifically, we summarize the evidence for neutrophil involvement in COVID-19 and the potential mechanisms underlying neutrophil recruitment and activation in this disease. We also review the literature on the role of neutrophils in the wound healing process and how aging and neutrophil heterogeneity may impact wound healing outcomes. Finally, we discuss the potential for neutrophil-targeted therapies to improve clinical outcomes in COVID-19 and wound healing.
Killer instincts: natural killer cells as multifactorial cancer immunotherapy
Authors: Nersesian Sarah , Carter Emily B. , Lee Stacey N. , Westhaver Lauren P. , Boudreau Jeanette E.
Published: November 2023

Natural killer (NK) cells integrate heterogeneous signals for activation and inhibition using germline-encoded receptors. These receptors are stochastically co-expressed, and their concurrent engagement and signaling can adjust the sensitivity of individual cells to putative targets. Against cancers, which mutate and evolve under therapeutic and immunologic pressure, the diversity for recognition provided by NK cells may be key to comprehensive cancer control. NK cells are already being trialled as adoptive cell therapy and targets for immunotherapeutic agents. However, strategies to leverage their naturally occurring diversity and agility have not yet been developed. In this review, we discuss the receptors and signaling pathways through which signals for activation or inhibition are generated in NK cells, focusing on their roles in cancer and potential as targets for immunotherapies. Finally, we consider the impacts of receptor co-expression and the potential to engage multiple pathways of NK cell reactivity to maximize the scope and strength of antitumor activities.