bluuebunny/crossref_metadata_2025 huggingface dataset:
Hydrocephalus-induced neurogenic stunned myocardium and cardiac arrest in a child: completely reversed with CSF diversion
Authors: Crevier-Sorbo Gabriel , Atkinson Jeffrey , Di Genova Tanya , Puligandla Pramod , Dudley Roy W. R.
Published: April 2019

Neurogenic stunned myocardium (NSM) is a potentially fatal cause of sudden cardiogenic dysfunction due to an acute neurological event, most commonly aneurysmal subarachnoid hemorrhage in adults. Only two pediatric cases of hydrocephalus-induced NSM have been reported. Here the authors report a third case in a 14-year-old boy who presented with severe headache, decreased level of consciousness, and shock in the context of acute hydrocephalus secondary to fourth ventricular outlet obstruction 3 years after standard-risk medulloblastoma treatment. He was initially stabilized with the insertion of an external ventricular drain and vasopressor treatment. He had a profoundly reduced cardiac contractility and became asystolic for 1 minute, requiring cardiopulmonary resuscitation when vasopressors were inadvertently discontinued. Over 1 week, his ventricles decreased in size and his cardiac function returned to normal. All other causes of heart failure were ruled out, and his impressive response to CSF diversion clarified the diagnosis of NSM secondary to hydrocephalus. He was unable to be weaned from his drain during his time in the hospital, so he underwent an endoscopic third ventriculostomy and has remained well with normal cardiac function at more than 6 months’ follow-up. This case highlights the importance of prompt CSF diversion and cardiac support for acute hydrocephalus presenting with heart failure in the pediatric population.
Predictors of endoscopic third ventriculostomy ostomy status in patients who experience failure of endoscopic third ventriculostomy with choroid plexus cauterization
Authors: Hale Andrew T. , Stanton Amanda N. , Zhao Shilin , Haji Faizal , Gannon Stephen R. , Arynchyna Anastasia , Wellons John C. , Rocque Brandon G. , Naftel Robert P.
Published: April 2019

OBJECTIVE

At failure of endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC), the ETV ostomy may be found to be closed or open. Failure with a closed ostomy may indicate a population that could benefit from evolving techniques to keep the ostomy open and may be candidates for repeat ETV, whereas failure with an open ostomy may be due to persistently abnormal CSF dynamics. This study seeks to identify clinical and radiographic predictors of ostomy status at the time of ETV/CPC failure.

METHODS

The authors conducted a multicenter, retrospective cohort study on all pediatric patients with hydrocephalus who failed initial ETV/CPC treatment between January 2013 and October 2016. Failure was defined as the need for repeat ETV or ventriculoperitoneal (VP) shunt placement. Clinical and radiographic data were collected, and ETV ostomy status was determined endoscopically at the subsequent hydrocephalus procedure. Statistical analysis included the Mann-Whitney U-test, Wilcoxon rank-sum test, t-test, and Pearson chi-square test where appropriate, as well as multivariate logistic regression.

RESULTS

Of 72 ETV/CPC failures, 28 patients (39%) had open-ostomy failure and 44 (61%) had closed-ostomy failure. Patients with open-ostomy failure were older (median 5.1 weeks corrected age for gestation [interquartile range (IQR) 0.9–15.9 weeks]) than patients with closed-ostomy failure (median 0.2 weeks [IQR −1.3 to 4.5 weeks]), a significant difference by univariate and multivariate regression. Etiologies of hydrocephalus included intraventricular hemorrhage of prematurity (32%), myelomeningocele (29%), congenital communicating (11%), aqueductal stenosis (11%), cyst/tumor (4%), and other causes (12%). A wider baseline third ventricle was associated with open-ostomy failure (median 15.0 mm [IQR 10.3–18.5 mm]) compared to closed-ostomy failure (median 11.7 mm [IQR 8.9–16.5 mm], p = 0.048). Finally, at the time of failure, patients with closed-ostomy failure had enlargement of their ventricles (frontal and occipital horn ratio [FOHR], failure vs baseline, median 0.06 [IQR 0.00–0.11]), while patients with open-ostomy failure had no change in ventricle size (median 0.01 [IQR −0.04 to 0.05], p = 0.018). Previous CSF temporizing procedures, intraoperative bleeding, and time to failure were not associated with ostomy status at ETV/CPC failure.

CONCLUSIONS

Older corrected age for gestation, larger baseline third ventricle width, and no change in FOHR were associated with open-ostomy ETV/CPC failure. Future studies are warranted to further define and confirm features that may be predictive of ostomy status at the time of ETV/CPC failure.
Intracranial volume versus static and pulsatile intracranial pressure values in children with craniosynostosis
Authors: Langvatn Erlend Aambø , Frič Radek , Due-Tønnessen Bernt J. , Eide Per Kristian
Published: April 2019

OBJECTIVE

Reduced intracranial volume (ICV) and raised intracranial pressure (ICP) are assumed to be principal pathophysiological mechanisms in childhood craniosynostosis. This study examined the association between ICV and ICP and whether ICV can be used to estimate the ICP.

METHODS

The authors analyzed ICV and ICP measurements from children with craniosynostosis without concurrent hydrocephalus and from age-matched individuals without craniosynostosis who underwent diagnostic ICP measurement.

RESULTS

The study included 19 children with craniosynostosis (mean age 2.2 ± 1.9 years) and 12 reference individuals without craniosynostosis (mean age 2.5 ± 1.6 years). There was no difference in ICV between the patient and reference cohorts. Both mean ICP (17.1 ± 5.6 mm Hg) and mean wave amplitude (5.9 ± 2.6 mm Hg) were higher in the patient cohort. The results disclosed no significant association between ICV and ICP values in the patient or reference cohorts, and no association was seen between change in ICV and ICP values after cranial vault expansion surgery (CVES) in 5 children in whom ICV and ICP were measured before and after CVES.

CONCLUSIONS

In this cohort of children with craniosynostosis, there was no significant association between ICV and ICP values prior to CVES and no significant association between change in ICV and ICP values after CVES in a subset of patients. Therefore, ICV could not reliably estimate the ICP values. The authors suggest that intracranial hypertension in childhood craniosynostosis may not be caused by reduced ICV alone but rather by a distorted relationship between ICV and the volume of intracranial content (brain tissue, CSF, and blood).
Adjacent-segment disease following two-level axial lumbar interbody fusion
Authors: Michael Alex P. , Weber Matthew W. , Delfino Kristin R. , Ganapathy Venkatanarayanan
Published: April 2019

OBJECTIVE

While long-term studies have evaluated adjacent-segment disease (ASD) following posterior lumbar spine arthrodesis, no such studies have assessed the incidence and prevalence of ASD following axial lumbar interbody fusion (AxiaLIF). The aim of this study was to estimate the incidence of ASD following AxiaLIF.

METHODS

The authors retrospectively reviewed the medical records of 149 patients who underwent two-level index AxiaLIF and had at least 2 years of radiographic and clinical follow-up. ASD and pre- and postoperative lumbar lordosis were evaluated in each patient. ASD was defined as both radiographic and clinically significant disease at a level adjacent to a previous fusion requiring surgical intervention. The mean duration of follow-up was 6.01 years.

RESULTS

Twenty (13.4%) of the 149 patients developed ASD during the data collection period. Kaplan-Meier analysis predicted a disease-free ASD survival rate of 95.3% (95% CI 90.4%–97.7%) at 2 years and 89.1% (95% CI 82.8%–93.2%) at 5 years for two-level fusion. A laminectomy adjacent to a fusion site was associated with 5.1 times the relative risk of developing ASD. Furthermore, the ASD group had significantly greater loss of lordosis than the no-ASD group (p = 0.033).

CONCLUSIONS

Following two-level AxiaLIF, the rate of symptomatic ASD warranting either decompression or arthrodesis was found to be 4.7% at 2 years and 10.9% at 5 years. Adjacent-segment decompression and postoperative loss of lumbar lordosis predicted future development of ASD. To the authors’ knowledge, this is the largest reported cohort of patients to undergo two-level AxiaLIF in the United States.
PERINGKAT FAKTOR PENYEBAB YANG MEMPENGARUHI TERJADINYA KLAIM DARI KONTRAKTOR KE OWNER PADA PROYEK KONSTRUKSI DI KOTA PADANG
Authors: Ariani Vivi
Published: April 2019

Abstrak Penelitian ini mempresentasikan hasil survei tentang penentuan peringkat faktor yang mempengaruhi terjadinya pengajuan klaim oleh penyedia jasa berdasarkan pengalaman dan pemahaman yang dimiliki atas tuntutan yang menjadi tanggung jawab pemilik proyek (pengguna jasa) pada proyek-proyek swasta dan pemerintah di Kota Padang. Penelitian ini bertujuan untuk mengidentifikasi faktor penyebab terjadinya tuntutan/klaim pada proyek konstruksi. Adapun pelaksanaan penulisan artikel ini diorganisasikan sebagai berikut: Pertama kajian literatur terkait klaim konstruksi dipaparkan dan diikuti dengan penyebab terjadinya pengajuan klaim yang dilaksanakan oleh penyedia jasa. Selanjutnya adalah analisis dan diskusi dan diakhiri oleh konklusi dan rekomendasi. Metodologi penelitian ini didesain bentuk penelitian kuantitatif dengan penyebaran survey kuesioner kepada praktisi industri konstruksi untuk menjawab tujuan penelitian. Pengumpulan data survey kuesioner  dilakukan kepada stakeholder proyek konstruksi di Kota Padang, meliputi pemilik proyek (owner), konsultan perencana, konsultan pengawas dan kontraktor. Teknik analisa data dilakukan dengan menggunakan statistik deskriptif yaitu: rata-rata (mean) dan standar deviasi. Mean digunakan untuk mengetahui nilai rata-rata dari jumlah respon untuk tiap jawaban yang tersedia. Selanjutnya berdasarkan mean dan standar deviasi ditetapkan rangking masing-masing pernyataan. Analisa dilanjutkan dengan menghitung natural cut off point untuk mereduksi peringkat/rangking. Dari hasil analisa, diperoleh 12 faktor (dari 28 faktor)  penyebab terjadinya klaim konstruksi oleh kontraktor terhadap pemilik proyek. Luaran penelitian diharapkan dapat membantu manajer proyek untuk mempermudah proses pengajuan dan efisiensi keberhasilan klaim proyek konstruksi.  Kata kunci: Klaim, Proyek Konstruksi, Kontraktor dan Pemilik
HUBUNGAN ANTARA PENGETAHUAN LINGKUNGAN DENGAN PERILAKU PROLINGKUNGAN SEKOLAH ADIWIYATA (Studi Kasus SDN 21 Taluak Kab. Agam)
Authors: Martini Martini
Published: April 2019

Penelitian bertujuan untuk menganalisis hubungan pengetahuan lingkungan dengan perilaku prolingkungan pada peserta didik sekolah dasar (SD) Adiwiyata. Perilaku prolingkungan dianalisis dengan model teori Lawrence Green dan pengetahuan lingkungan diukur menggunakan skala NEP. Hasil penelitian ini sesuai dengan teori Lawrence Green yakni pengetahuan lingkungan tidak berhubungan dengan perilaku prolingkungan pada peserta didik sekolah Adiwiyata. Hasil analisis perilaku prolingkungan didapatkan bahwa perilaku prolingkungan sekolah Adiwiyata sangat baik. Dengan demikian program Adiwiyata mempunyai pengaruh positif dalam mengubah perilaku prolingkungan
STUDI EKSPERIMENTAL PERILAKU TEKAN BAJA RINGAN DENGAN VARIASI PROFIL PENAMPANG
Authors: Fitrah Ridho Aidil , Herman Hazmal
Published: April 2019

Penelitian tentang baja ringan sudah sangat meningkat untuk menentukan analisis dan desain yang tepat. Salah satu peraturan di Indonesia tentang desain struktur baja canai dingin atau ringan adalah SNI 7971: 2013. Namun, ada hal yang menjadi fokus perhatian pada baja ringan saat didesain pada elemen tekan. Salah satu tekuk yang terjadi pada elemen tekan baja ringan yaitu tekuk lokal yang disebabkan oleh faktor geometri atau penampang. Setiap penampang baja ringan memberikan bentuk tekuk yang berbeda-beda. Untuk itu perlu dilakukan studi eksperimental tentang perilaku tekan pada beberapa bentuk profil baja ringan kanal C baik tunggal dan simetris ganda, seperti double channel box dan double channel back to back. Uji tekan akan dilakukan dengan universal testing machine dengan jumlah benda uji sebanyak 3 sampel, 1 sampel untuk masing-masing penampang, sebagai kolom pendek. Hasil pengujian ini adalah berupa kurva beban versus perpendekan yang akan dibandingkan dengan hasil analitik berdasarkan peraturan SNI 7971:2013. Selain itu, propagasi tekuk lokal yang terjadi di masing-masing penampang juga diamati. Berdasarkan hasil pengujian tersebut didapatkan penampang double channel box memiliki nilai beban ultimit dan kekakuan yang signifikan dibandingkan double channel back to back dan single channel. Selanjutnya, perhitungan kapasitas tekan berdasarkan SNI 7971:2013 sangat konservatif.
EVALUASI FASILITAS DAN JARAK TEMPAT PERHENTIAN KENDARAAN PENUMPANG UMUM (TPKPU) TRANS PADANG
Authors: Yermadona Helga
Published: April 2019

Koridor I Trans Padang mempunyai 73 tempat perhentian kendaraan penumpang umum (TPKPU) yaitu 45 halte dan 28 tempat pemberhentian bus (TPB) yang terdiri dari arah Imam Bonjol-Batas Kota sebanyak 35 unit (21 halte dan 14 TPB) dan arah Batas Kota–Imam Bonjol sebanyak 38 unit (24 halte dan 14 TPB). Di lapangan ditemukan bahwa informasi atau petunjuk jadwal kedatangan dan keberangkatan Trans Padang tidak dicantumkan di halte/TPB. Sehingga penumpang kesulitan memprediksi jadwal bus dan berapa lama waktu yang mereka perlukan untuk menunggu bus. Tujuan penelitian untuk mengevaluasi fasilitas dan jarak antar halte/TPB sesuai Keputusan Direktur Jenderal Perhubungan Darat Nomor: 271/HK.105/DRJD/96. Penelitian dilakukan dengan survey halte/TPB Trans Padang sepanjang Koridor I, kemudian mengevaluasi dan membandingkan kondisi eksisting hasil survey dengan standar yang ada. Berdasarkan analisis didapatkan hasil banyak halte/TPB yang tidak memenuhi syarat kelengkapan fasilitas. Berdasarkan jarak antar halte/TPB yang memenuhi syarat pada arah Imam Bonjol-Batas Kota sebanyak 19 halte/TPB, dan arah Batas Kota-Imam Bonjol 21 halte/TPB. Kata kunci: Trans Padang, halte, TPB dan Koridor I.
PEMBUATAN KAPAL NELAYAN FIBERGLASS KOTA PADANG DENGAN METODE HAND LAY UP
Authors: Ardhy Sanny , Putra Meiki Eru Eru , Islahuddin Islahuddin Islahuddin
Published: April 2019

Kapal nelayan dari bahan kayu lambat laun sudah mulai ditinggalkan oleh nelayan. Kini, nelayan sudah banyak beralih menggunakan kapal dari material fiberglass. Ini dikarenakan jumlah bahan kayu yang sudah semakin terbatas, dan harganya juga sangat mahal. Selain itu, kapal kayu membutuhkan banyak sekali perawatan dan masa pakainya juga terbatas. Sementara kelebihan kapal fiberglass antara lain, usia atau masa pakai kapal lebih tahan lama, perawatan jauh lebih mudah dan hemat biaya (cost). Kapal fiber juga jauh lebih ringan, dan lebih maksimal dalam produksi tangkap ikan. Proses pembuatan kapal fiberglass yang banyak dibuat, menggunakan teknik Fiberglass Reinforced Plastic (FRP). Dalam pembuatan kapal fiber, ada dua metode laminasi yang sering digunakan, yakni Hand Lay Up dan Chopper Gun. Metode ini adalah metode laminasi yang paling mudah dan sederhana. Hand Lay Up adalah metode cetakan terbuka (open mould). Metode ini dilakukan dengan cara mengaplikasikan resin pada bahan penguat dengan menggunakan kuas/rol. Penelitian dilakukan di daerah nelayan Pantai Muaro Padang. Ada lima unit kapal nelayan fiberglass yang menjadi sampel. Tujuan penelitian ini untuk membantu nelayan, khususnya memproduksi kapal fiberglass yang jauh lebih baik untuk memaksimalkan hasil tangkapan ikan.Kata Kunci : FRP, hand lay up, resin, open mould, Pantai Muaro
ANALISIS PERANCANGAN APLIKASI SISTEM INFORMASI E-MCARD BERBASIS ANDROID PADA PT. XYZ
Authors: Sari Meritha Indah , Djahidin Danny Yudin
Published: April 2019

PT. XYZ is a local Indonesian pharmaceutical company that is currently developing,where in the development of a company the role of Information Technology is very important along with the very rapid development.PT. XYZ in the application of Information Technology data processing is quite good and has an information system that can be used to analyze data. But there are still problems in the process of making a report about a Marketing employees visit that affects the salaries and incentives of the Marketing department.The purpose of this study is to be able to measure the process of achieving the target of visits given by the Company to each of the Marketing Department Employees,product promotion to doctors, and help monitor sales targets, where researchers use the SWOT and Fishbone Analysis Methods in the analysis process. Keywords: Analisis, Perancangan, Android, SWOT, Fishbone
PERANCANGAN SISTEM INFORMASI PENGENALAN FENOMENA ALAM BERBASIS ANIMASI SECARA ONLINE (Studi Kasus : Badan Meteorologi Klimatologi Dan Geofisika)
Authors: Khasanah Khasanah
Published: April 2019

The information system introduction of natural phenomenon defined as systems that convey information about the occurrence of natural phenomena. Problems that occur at this time is the delivery of information about natural phenomena only briefly obtained by the print or broadcast media. The problem solved by trying to build an information system design introduction of natural phenomena based online animations are developed using the prototype method. Animation presented in this information system is the chronological occurrence of a natural phenomenon while the system information of the website as a medium of information delivery. This system is expected to be a tool to facilitate the delivery of information about natural phenomena well anywhere and anytime as well as make it easier to add knowledge about the natural phenomena that occur.
Paradigmatic changes in the modern Philosophy of Education
Authors: Dolska Olga
Published: April 2019

The article continues the tradition of thinking about pedagogical rationality. The presence of its two levels is analyzed ‒ meaningful and formally-functional, their significance for didactics is substantiated. Their implementation is demonstrated in the Educational strategies. The article speaks of a more attentive attitude to the formal-functional level in the formation of didactics in the new paradigm of Education ‒ the Education of the information society using the possibilities of the Internet. An overview of Internet resources is given, the emergence of the term “open Educational resources” is analyzed, a chronology of the idea of ​​their introduction into educational practices is reviewed.

Building on the best psychological and pedagogical concepts of the last decades, the need to form new pedagogical strategies is emphasized. The theory that is adapted to the working conditions in cyberspace is connectivism, is analyzed. It grows on the basis of new insights and capabilities of digital teaching materials that qualitatively differ from traditional teaching materials by their ability to manage them.

Using examples of Modern trends, the importance of this theory for new forms of Education is emphasized; the need to form new competencies in the form of information skills is being updated. Using examples of modern trends, the importance of this theory for new forms of education is emphasized. Practices and possibilities of information and communication forms of Education are analyzed: from distance learning courses and open on-line courses to the practice of Open Universities.
Sexuality as a phenomenon of (social) being of a person and subject of educational discourse
Authors: Kaluha Volodymyr
Published: April 2019

The phenomenon of sexuality is the cornerstone of being of a person, which by nature manifests itself socially. At the same time, currently sexuality is a stumbling block and a Sisyphean stone to "push" throughout human existence. The afore-mentioned place and role of sexuality in human being are directly related to the peculiarities of the outlook of a civilized man and modern culture in general. In other words, the peculiarity of the worldview and the arrangement of the cultural space of a civilized man is largely a cause of transformation of sexuality, as an attribute of human existence, into a dominant source of internal stress, mental disorders, various deviations, and ontological confusion and alienation in general.

As a result, an impartial understanding of nature of the phenomenon of sexuality and its functional essence in human existence definitely facilitates its emancipation, especially in the context of upbringing of the younger generation. An appeal to critical thinking contributes for critical elimination of the bias, which, among other aspects, establishes a fact that the cognitive abilities of a person are limited. The latter means that everything what is widely recognized is, in fact, only a generally accepted paradigm, including the alleged scientifically substantiated interpretation of the manifestations of sexuality associated with the sexual sphere of norms and rules, as well as basic ideological settings, and by no means a combination of truths. An integral and adequate representation of the phenomenon of sexuality can be formed on the basis of the analysis of relevant informational achievements in the field of science and philosophy, philosophical art, esoteric experience, etc.

Therefore, firstly, the article is aimed at comprehension of key stereotypes and dogmas, which are widespread in both public and scientific or expert opinions. Secondly, the article thoroughly discloses a number of features and attributes of the phenomenon of sexuality, taking into account the experience acquired through the mediation of the world mythology and esoteric experience in the form of the so-called philosophical art. Thirdly, the situational analysis of a person is contextualized through one’s sexual nature. Consequently, the article focuses on issues of sexual education and ‘enlightenment’ of a person depending on a variety of age and social positions, as well as the community as a whole.

The introduction of the relevant research activity of the author of the article has been instigated by the obvious lack of scientific substantive studies on the nature of the phenomenon of sexuality and its functional aspect on the territory of Ukraine. At the same time, the Ukrainian community needs significant educational influence on issues of self-realization of citizens, in particular in the sexual and private spheres.
The origins and approaches of the emergence of a new bioethics and the program “Integrative Bioethics”. Part 2
Authors: Hoffmann Thomas Sören
Published: April 2019

The article compares different models of bioethics. The dominant model considers bioethics as just a new area of applied ethics focusing in its origin mainly on questions of medical ethics like those rising from reproductive medicine. Within the framework of this concept, the formal application of ethical principles on medical practices is normally understood as a strategy for the preservation of personal autonomy of the individual. Another model linked e.g. to the names of Van Rensselaer Potter or Hans Jonas can be called a "holistic" one and refers to ethical issues discussed within the greater context of "general meditation" of life in general, nature and human life-worlds. Holistic bioethics focuses on the idea of integrity, and it also allows an internal "living" pluralism of perspectives, which corresponds to the self-differentiation of life in a plurality of life-worlds. The third model is an integrative bioethics which not only tries to combine the perspectives of autonomy on the one hand, life and nature as a whole on the other, but also shows that bioethics is founded on its own sources of normativity (e.g. in the idea of life). From these sources also rises its task of “integrating” the perspectives of different scientific disciplines on issues of life in general. The concept of "integrative bioethics" is promoted in the article because of the following characteristics: integrative bioethics considers all kinds of interaction between autonomous persons, living beings and nature in general; it is transdisciplinary and therefore based on a dialogue of all sciences in which bioethical awareness of the problem may arise; it is open also to non-scientific manifestations of individual and social consciousness and therefore in discussing live in a normative sense nevertheless stays in contact with the real life-worlds of real people. At the end of the article integrative bioethics is discussed with regard to the example of the meaning of the idea of a “natural will”.
The Provocative Philosophy of Education: Fata Morgana of Universalism and Temptation of Singularities (K. P. Liessmann, R. D. Precht, A. Reckwitz)
Authors: Kultaieva Maria
Published: April 2019

Some polemic versions of the contemporary philosophy of education are regarded which lend it the character of the provocatively through setting accents on the intern paradoxes of changes designed of the educational modernization and formed under the pressure of globalization. The contextual conditions of the postindustrial transformations in the educational system are explicated which were structured by the influences of the industrial imperatives. The theoretical explorations of K.P. Liessmann, R.D. Precht   and A. Reckwitz were chosen to show the structure and the content of changes in education including the consequences of the educational globalization. The tendency to refuse the European educational priorities is critically analyzed. There is the negative way to state the logic of the industrialism as the logic of the universality preserving postmodern singularity of the educational institutions what makes evident the ambivalence of the knowledge society. Some attempts are explicated, which try to give rehabilitation for the “useless knowledge” in the curriculum options what is connected with getting back the ideal of the cultivated man and with actualizing the hidden senses of conservatism (Liessmann) or pseudo-revolutionary appeals (Precht). The provocative philosophy of education in its different representations might be regarded as a special mode for activation of the theoretical critical thinking with the purpose for early detecting of risks, cultural and pedagogical pathologies appearing through postindustrial shifts in the culture, which can provoke some symptoms of the re-feudalization in the academically communities. It is concentrated not only on the positive side of the educational transformations, but else on their negative effects, loading of social and psychological traumas, and proposes different variants answering on the claims of the contemporary education aiming their additionally verification. The intrinsic contradictoriness of this kind of philosophy can be acceptable as a articulating of its openness, connected with its principle infinitely, and might be regarded as productive strategy of communication in the discourse devoted to the perspective of the development of education in the uncertain postindustrial conditions.
Philosophy and Teachers
Authors: Adorno Theodor W.
Published: April 2019

Teodor Adorno's work Philosophy and Teachers was first read as a report at the Frankfurt Studenthome in November 1961. In this report Adorno continued the topic of criticism of those factors of the then formation of West Germany, which made impossible a personal fight intellectual to with the cultural remnants of a totalitarian society. Adorno drew attention an exam in philosophy, important element of the educational process. This exam should pass composed of future teachers, candidates for the work of the teacher of gymnasium. This exam should be composed by future teachers, candidates for the work of the teacher of gymnasium. Adorno noticed the tendency of formalistic adherence to the Rules of Examination by some future teachers who are unable to understand the humanistic, emancipatory and spiritual essence of philosophy, and therefore do not understand the purpose of conducting this exam. Adorno honored the long tradition of academic freedom of the German University and noticed the figure of the German philosopher, describing him as the man whose intellectual activity influenced the humanization of the German University,  which directly influenced to the corresponding cultural transformations. But in post-war universities in the Federal Republic of Germany there is a trend to the principles of scientific knowledge. This tendency is coupled with the attitude of some future teachers to knowledge as appropriation to the consumer way, was due to the absence of personal love for their own specialty and to their students. Adorno was convinced that such teachers are indifferent to their specialty and do not have a calling to him. Adorno defined as a sign to the absence of calling in these people is intellectual negligence, provincial speech and provincial inability to understand human freedom as a spiritual value. Such teachers are incapable of offering new knowledge to their students by way of perfekt speech and by way of perfekt written presentation. As completely different Adorno offered to see a person who is capable to appropriation of the knowledge that is needed to understand hemseif and his professional obligation. This person can will use self-understand and self-reflection, and therefore she can will independently to understand of the sense of their pedagogical work. This person will be faithful and patient in carrying out his work for the practical introduction of humanistic ideals of prior philosophical knowledge into society.
Clinical Development of FGFR3 Inhibitors for the Treatment of Urothelial Cancer
Authors: Ibrahim Tony , Gizzi Marco , Bahleda Ratislav , Loriot Yohann
Published: April 2019

The fibroblast growth factor receptor 3 (FGFR3) plays critical roles in driving oncogenesis of a subset of patients with urothelial carcinomas (UC). Growing evidence from preclinical studies suggests that FGFR3 inhibition can reduce proliferation and survival in vitro and in vivo models of FGFR3-altered UC. Early clinical trials investigating selective FGFR3 inhibitor have reported preliminary signs of antitumor activity in advanced UC patients with selected FGFR3 mutations or fusions. Currently, phase 3 trials with erdafitinib and rogaratinib are enrolling patients with known FGFR3 alterations. Future combinations with targeted therapies or immune checkpoint inhibitors may increase the efficacy of selective FGFR3 inhibitors. Herein, we discuss current clinical development of FGFR3 inhibitors as well as unsolved questions with regards to patient selection, management of toxicities and mechanisms of resistance to selective FGFR3 inhibitors.
Word Matrix Rewriting Systems
Authors: Bisht Raj Kishor , Nishida Taishin Yasunobu , Yamamoto Kouhei
Published: April 2019

We introduce word matrices and word matrix rewriting systems. A word matrix over an alphabet ∑ of k letters is a k × n rectangular matrix with entries of nonnegative integers. A word matrix represents a set of words. The i-th row corresponds to the i-th letter in ∑ (thus the letters in ∑ are ordered as a1, . . . , ak). Each column vector represents a set of words which have the vector as the Parikh vector. The word matrix represents the concatenation of all sets represented by column vectors. A word matrix rewriting system consists of a set of rewriting rules which rewrite word matrices and an initial word matrix (the axiom). A word matrix rewriting system generates a set of word matrices by iterated applications of rules to the axiom and generates a language which is the union of all sets represented by the matrices. A word matrix rewriting system is a kind of (restricted) parallel rewriting system with scattered context dependency and hence can generate non-context-free languages, e.g., { anbncn | 1 ≤ n}. We define variants of word matrix rewriting systems and show an infinite hierarchy among them. Some language theoretical problems, including relations among Chomsky hierarchy, closure properties, and decision properties, are considered.
Introducing Mass-based Rough Mereology in a Mereological Universe with Relations to Fuzzy Logics and a Generalization of the Łukasiewicz Logical Foundations of Probability
Authors: Polkowski Lech
Published: April 2019

We investigate a model for rough mereology based reasoning in which things in the universe of mereology are endowed with positive masses. We define the mass based rough inclusion and establish its properties. This model does encompass inter alia set theoretical universes of finite sets with masses as cardinalities, probability universes with masses as probabilities of possible events, sets of satisfiable formulas with values of satisfiability, measurable bounded sets in Euclidean n-spaces with n-dimensional volume as mass, in particular complete Boolean algebras of regular open or closed sets – the playground for spatial reasoning and geographic information systems1. We define a mass-based rough mereological theory (in short mRM-theory). We demonstrate affinities of the mass-based rough mereological mRM-theory with classical many-valued (‘fuzzy’) logics of Łukasiewicz, Gödel and Goguen and we generalize the theses of logical foundations of probability as given by Łukasiewicz. We give an abstract version of the Bayes theorem which does extend the classical Bayes theorem as well as the proposed by Łukasiewicz logical version of the Bayes formula. We also establish an abstract form of the betweenness relation which has proved itself important in problems of data analysis and behavioral robotics. We address as well the problem of granulation of knowledge in decision systems by pointing to the most general set of conditions a thing has to satisfy in order to be included into a formally defined granule of knowledge, the notion instrumental in our approach to data analysis. We address the problem of applications by pointing to our work on intelligent robotics in which the mass interpreted as the relative area of a planar region is basic for definition of a rough inclusion on regular open/closed regions as well as in definition of the notion of betweenness crucial for a strategy for navigating teams of robots.
An Approach of Proximity in Rough Set Theory
Authors: Tiwari Surabhi , Singh Pankaj Kumar
Published: April 2019

In this paper, we have constructed topological structures on rough sets by choosing the path of proximity relations on approximation spaces. So, by this virtue of purpose, we have used rough metric to define nearness concept between rough sets. Some basic results have been proved on this new nearness structure named as rough proximity. The study is well supported by examples. Finally, the theory is developed to construct the compactification of a rough proximity space.
Calibration, Selection and Identifiability Analysis of a Mathematical Model of the in vitro Erythropoiesis in Normal and Perturbed Contexts
Authors: Duchesne Ronan , Guillemin Anissa , Crauste Fabien , Gandrillon Olivier
Published: April 2019

The in vivo erythropoiesis, which is the generation of mature red blood cells in the bone marrow of whole organisms, has been described by a variety of mathematical models in the past decades. However, the in vitro erythropoiesis, which produces red blood cells in cultures, has received much less attention from the modelling community. In this paper, we propose the first mathematical model of in vitro erythropoiesis. We start by formulating different models and select the best one at fitting experimental data of in vitro erythropoietic differentiation obtained from chicken erythroid progenitor cells. It is based on a set of linear ODE, describing 3 hypothetical populations of cells at different stages of differentiation. We then compute confidence intervals for all of its parameters estimates, and conclude that our model is fully identifiable. Finally, we use this model to compute the effect of a chemical drug called Rapamycin, which affects all states of differentiation in the culture, and relate these effects to specific parameter variations. We provide the first model for the kinetics of in vitro cellular differentiation which is proven to be identifiable. It will serve as a basis for a model which will better account for the variability which is inherent to the experimental protocol used for the model calibration.
Effect of Yoga on Balance in Geriatric Population
Authors: Patel Krishna Ketan , Deshmukh Mayura , Palekar Tushar
Published: April 2019

Background : The geriatric population is defined as population aged 60 years and above. (1)During this age many of the systems undergo deterioration. Balance problems in elderly are most commonly due to multi factorial condition which may include age related or disease-related declines in the balance system. Research shows that altered balance is the greatest collaborator towards falls in the elderly with a high correlation between balance deficit and the incidence of falls. Iyengar yoga, one of the active, or Hatha, yoga techniques, is a system for developing physical and mental well-being through stretching of all muscle groups for strength, flexibility, and physical balance. Yoga as a complementary therapy is thought to be more therapeutic than traditional exercise because it involves active engagement between mind and body. Its practice has been associated with increased muscle strength, endurance, flexibility, range of motion and cardiopulmonary endurance. It mainly works on increasing body awareness and proprioception, which will lead to improvement of balance in older adults. Objectives: To compare pre and post score of Modified Clinical Test of Sensory Interaction in Balance (CTSIB-M). To compare pre and post score of Time up and go test. Materials and Methodology: This was an experimental study that included 40 participants, healthy older adults between the age group 60-75 years, both male and female. The subjects were randomly divided in to 2 groups; Group A was the experimental group whereas group B was the control group. The experimental group was made to perform yogasanas for the duration of four weeks for 5 times a week whereas the control group was not given any intervention. Result and Conclusion: The study conducted concludes that yogasanas are effective in improving balance in elderly individuals at the end of four weeks compared to control group. Thus, it can be used clinically to improve balance in geriatric population.
Lógica borrosa como herramienta de apoyo en la elaboración de un presupuesto base cero: Caso artesanos de muebles de madera.
Authors: Espinoza González Juan Ennis , Luna Altamirano Kléber Antonio , Sarmiento Espinoza William Henry , Erazo Álvarez Juan Carlos
Published: April 2019

El presente artículo, se refiere a la estructura de un presupuesto basado en una técnica nueva de análisis para los artesanos en la fabricación de muebles de madera del cantón Santiago de Méndez de la Provincia de Morona Santiago-Ecuador, denominado Presupuesto Base Cero (PBC), ya que el problema radica en el desconocimiento de los administradores de estas empresas al momento de construir un presupuesto. El objetivo de este estudio es entregar a estos artesanos una nueva forma de elaborar presupuestos basado en objetivos y metas trazados por estas organizaciones, la metodología utilizada se basa en el apoyo de herramientas de avanzada que ofrece la lógica difusa, como son los números borrosos trapezoidales (NBTr), en donde se atrapa valores correctos presupuestarios con la finalidad de reducir la incertidumbre en el momento de realizar proyecciones a futuro. Como resultado de esta investigación es lograr conseguir que los niveles presupuestarios sean ideales y alcanzables con el propósito de mejorar la gestión en estas empresas artesanales.
Теплопроводность цементных армированных плит при нестационарном тепловом режиме на основе данных экспериментальных исследований и численного моделирования
Authors: Кудряшов Вадим , Ботян Сергей
Published: April 2019

Проанализированы методы определения теплофизических характеристик материалов в ходе проведения испытаний по различным методикам и видам теплового режима. Разработана методика и проведены экспериментальные исследования динамики прогрева модельных образцов цементных армированных плит толщиной 12,5 и 25 мм. Получены зависимости изменения температуры от времени на обогреваемой и необогреваемой поверхности материала образцов различной толщины при нестационарном тепловом режиме в диапазоне температур от 20 до 1000 °С. Разработана расчетная модель и решена обратная задача теплопроводности с оценкой эффективных коэффициентов теплопроводности рассматриваемых образцов в диапазоне температур от 20 до 1000 °С.
Экспериментальные исследования пожарного ствола СПРУК 50/0,7 «Викинг» при подаче воды
Authors: Пармон Валерий , Камлюк Андрей , Волчек Ярослав , Асилбейли Рамиз , Морозов Артем
Published: April 2019

Приведены результаты экспериментальных исследований гидродинамических параметров пожарного ствола СПРУК 50/0,7 «Викинг»: расхода огнетушащего вещества, дальности подачи огнетушащего вещества, эффективной дальности распыленной струи огнетушащего вещества и средней интенсивности орошения.
Экспериментальные исследования влияния конструктивных элементов оросителей на кратность воздушно-механической пены
Authors: Камлюк Андрей , Лихоманов Алексей
Published: April 2019

Проведены экспериментальные исследования процесса образования воздушно-механической пены низкой кратности в розеточных оросителях с целью установления влияния отдельных элементов их конструкции на кратность получаемой пены. Проведен анализ полученных экспериментальных данных и определены наиболее перспективные направления повышения эффективности тушения пенными оросителями в автоматических установках пожаротушения.
Пороговые значения травмирования человека при воздействии избыточного давления взрыва
Authors: Иваницкий Александр , Петрико Елена
Published: April 2019

Изучены литературные данные механизма воздействия избыточного давления взрыва топливовоздушных смесей на организм человека для определения возможных последствий. Установлено, что наиболее чувствительны к воздействию волны избыточного давления взрыва органы слуха, дыхания, желудочно-кишечного тракта и головной мозг, а основной травмирующий эффект зависит от величины избыточного давления взрыва. Определены пороговые значения травмирования человека при воздействии избыточного давления взрыва, на основании чего установлено, что на первоначальном этапе проведения экспериментальных исследований по определению последствий воздействия избыточного давления взрыва на человека возникает необходимость изучения аэродинамических характеристик поведения тела человека с учетом его антропометрических данных.
Технология получения и исследование свойств микродисперсного гидрофобного адсорбента на основе бентонитовой глины для ликвидации аварийных разливов нефти и нефтепродуктов
Authors: Журов Марк
Published: April 2019

В статье представлены результаты разработки технологии получения и исследований эксплуатационных и физико-химических свойств микродисперсного гидрофобного адсорбента на основе бентонитовой глины Острожанского месторождения, применяемого для ликвидации аварийных разливов нефти и нефтепродуктов.
Анализ воздействия оползневых процессов на водохранилища, озера, водоемы при землетрясениях
Authors: Ахмедов Машрап , Салямова Клара
Published: April 2019

На основе изучения причин природных явлений, таких как обвалы и оползни в горах в результате сильных землетрясений, произошедших в прошлые времена в разных странах земного шара, сделан анализ разрушения завальных дамб. Выполнен анализ последствий воздействия на гидротехнические сооружения этих природных бедствий, приводящих к разрушению плотин, наводнению, значительным повреждениям сети железных, шоссейных дорог и т.п.. Это все влияет на масштаб ущерба от землетрясений.
Программное обеспечение для своевременного выявления негативного информационно-психологического воздействия, осуществляемого в социальных сетях
Authors: Голубева Светлана , Хмарский Петр
Published: April 2019

Рассмотрено разработанное программное обеспечение для выявления, предупреждения и нейтрализации последствий негативного информационно-психологического воздействия, осуществляемого в социальных сетях на специалистов экстремального профиля. Работа программного обеспечения реализуется в 5 основных этапов: инициализация, предварительная обработка информации, сбор неструктурированных данных, первичная и вторичная обработка. Разработанное программное обеспечение не является полностью автоматизированной системой и придается в помощь психологу подразделения, который обладая полученной информацией, осуществляет ее последующий анализ, прогнозирует возможные последствия и при выявлении опасности для морально-психологического состояния личного состава принимает меры для ее нейтрализации (предотвращения).
Экспериментальное исследование поведения горения n-гептана в бассейнах различного размера при низком давлении
Authors: Джан Ван , Вэй Ванг , Руй Янг
Published: April 2019

Проведен анализ температуры пламени, скорости горения, теплового потока на разных стадиях горения резервуаров с нефтью на высокогорном плато и на равнине. Скорость выделения тепла, скорость горения, распределение температурного поля и излучения были зафиксированы и проанализированы. Было определено соотношение размеров нефтяного бассейна и массовой скорости горения. Оказалось, что массовая скорость горения варьирует линейно в зависимости от размеров нефтяного бассейна. Было обнаружено, что классическая теория не подходит для корректного предопределения скачка температуры вследствие низкого давления и низкой концентрации кислорода. Анализ также показал, что чем больше площадь бассейна, тем больше тепловой поток. Отношение размеров нефтяного бассейна к тепловому потоку было представлено графически.
Использование информации пожарных извещателей в режиме реального времени при работе пожарного расчета в высотных зданиях
Authors: Шу Сюэмин , Ву Джинжин , Танг Шиян , Ху Джун , Гуан Джингфу
Published: April 2019

В случае возникновения пожара в здании необходимо собрать как можно больше полной информации о горящем здании. Имея такую информацию, пожарный расчет может своевременно выехать к месту происшествия для подавления огня на ранней стадии. Использование технологии IoT (Internet of Thing – Интернет вещей) позволяет в режиме реального времени контролировать координаты и текущее состояние противопожарного оборудования, такого как пожарные гидранты, дымовые извещатели, извещатели пламени, собирать информацию о состоянии конструкций зданий и расположения очага возгорания. Аналитическое моделирование дает возможность спрогнозировать характер распространения пожара, местоположение по-страдавших людей и пожарных-спасателей. Такая информация может быть полезной спасателям в ходе ликвидации пожара, значительно повышая эффективность пожаротушения и спасения. Проведен ряд исследований по обнаружению пожаров в высотных зданиях, включающих технологию динамической оценки полей пожарного риска в процессе реагирования, систему локализации персонала в высотных зданиях и сетевые пожарные технологии. Указанные технологии могут помочь руководителям тушения пожара производить разведку на пожаре и спасение людей, и уже апробированы в одном из пожарных подразделений Китая.
Преимущества и недостатки существующих оконечных средств автоматизированной системы централизованного оповещения
Authors: Качан Вадим , Кобяк Валерий
Published: April 2019

Проведен обзор существующих технических средств передачи сигналов и экстренной информации об угрозе или возникновении чрезвычайных ситуаций, рассмотрены преимущества и недостатки существующих оконечных средств оповещения, а также вопросы, касающиеся озвучивания территории техническими средствами речевого доведения информации. В результате сравнительного анализа используемых оконечных средств оповещения предложены способы их совершенствования.