bluuebunny/crossref_metadata_2025 huggingface dataset:
Construction of a molecular diagnostic system for neurogenic rosacea by combining transcriptome sequencing and machine learning
Authors: Mao Rui , Li Ji
Published: January 2024

Patients with neurogenic rosacea (NR) frequently demonstrate pronounced neurological manifestations, often unresponsive to conventional therapeutic approaches. A molecular-level understanding and diagnosis of this patient cohort could significantly guide clinical interventions. In this study, we amalgamated our sequencing data (n = 46) with a publicly accessible database (n = 38) to perform an unsupervised cluster analysis of the integrated dataset. The eighty-four rosacea patients were partitioned into two distinct clusters. Neurovascular biomarkers were found to be elevated in cluster 1 compared to cluster 2. Pathways in cluster 1 were predominantly involved in neurotransmitter synthesis, transmission, and functionality, whereas cluster 2 pathways were centered on inflammation-related processes. Differential gene expression analysis and WGCNA were employed to delineate the characteristic gene sets of the two clusters. Subsequently, a diagnostic model was constructed from the identified gene sets using linear regression methodologies. The model's C index, comprising genes PNPLA3, CUX2, PLIN2, and HMGCR, achieved a remarkable value of 0.9683, with an area under the curve (AUC) for the training cohort's nomogram of 0.9376. Clinical characteristics from our dataset (n = 46) were assessed by three seasoned dermatologists, forming the NR validation cohort (NR, n = 18; non-neurogenic rosacea, n = 28). Upon application of our model to NR diagnosis, the model's AUC value reached 0.9023. Finally, potential therapeutic candidates for both patient groups were predicted via the Connectivity Map. In summation, this study unveiled two clusters with unique molecular phenotypes within rosacea, leading to the development of a precise diagnostic model instrumental in NR diagnosis.
Application of ligation of ascending branch of uterine artery combined with ligation of the utero-ovarian artery anastomoses for hemostasis in cesarean section
Authors: Hu Shuang , Xia Li , Lin Jinxiao , Xie Yongjin
Published: January 2024

Background: Postpartum hemorrhage is a life-threatening pregnancy complication, which is still the main preventable cause of high morbidity and mortality in pregnant women.During cesarean section,lower uterine segment hemorrhage is an important cause of postpartum hemorrhage.We aim to evaluate the efficacy and safety of the application of "ligation of the ascending branch of uterine artery combined with ligation of the utero-ovarian artery anastomoses" for hemostasis during cesarean section.
Methods: 47 patients admitted to the Second Department of Obstetrics and Maternity of Fujian Maternal and Child Care Service Center from March 2018 to March 2022 were collected. There were 11 cases of placenta previa with placenta implantation and scar uterus. Placenta previa with placenta implantation in 3 cases; Placenta previa combined with twin in 1 case; Placenta previa with scar uterus in 12 cases; Placenta previa in 3 cases; Placenta implantation complicated with severe preeclampsia and scar uterus in 1 case; Placenta implantation with scar uterus in 1 case; Placental implantation in 2 cases; 1 case of twin with uterine myoma and 1 case with cicatricial uterus; 1 case of twin with severe preeclampsia; There were 2 simple twins; Breech in 1 case; Placental abruption: 1 case; Uterine fibroids in 3 cases; Scar uterus: 3 cases. In all cases, intravenous injection of 100 micrograms of carbetin was routinely used to promote uterine contraction after delivery of the fetus. For those who still had diffuse bleeding in the lower segment of the uterus after ligation of the ascending branch of the uterine artery，combined suture was performed to ligate the the utero-ovarian artery anastomoses, and the short and long term prognosis, uterine were analyzed.
Results: All 47 patients were successfully hemostatic and no hysterectomy was performed.
Conclusions: Ligation of the ascending branch of uterine artery combined with ligation of the utero-ovarian artery anastomoses is one of the fast, safe, effective and feasible hemostasis methods in cesarean section. The combination of the latter can block the uterine blood flow and further reduce the amount of intraoperative bleeding, especially for uterine body bleeding, which can be more rapid and effective hemostasis.
Repeated Transplantation of Human Cranial Bone-Derived Mesenchymal Stem Cells Improved Motor Function and Electrophysiological Recovery in Spinal Cord Injury Rat Model
Authors: Maeda Yuyo , Mitsuhara Takafumi , Okamoto Misaki , Otsuka Takashi , Hara Takeshi , Kuwabara Masashi , Takeda Masaaki , Horie Nobutaka
Published: January 2024

Background
Mesenchymal stem cell (MSC)-based therapy has been applied in several clinical trials of spinal cord injury (SCI). We successfully established MSCs from human cranial bone and developed a longitudinal neuromonitoring technique for rodents. Recent studies have suggested the possibility of multiple transplantations as a new therapeutic strategy in addition to single transplantation. However, to our knowledge, there are no reports on the electrophysiological effects of multiple MSCs transplantation in SCI using transcranial electrical stimulation motor-evoked potentials (tcMEPs). Therefore, this study aimed to elucidate the efficacy and mechanism of action of multiple transplantation using this novel technique.
Methods
SCI rat model was established using the weight-drop method, and human cranial bone-derived MSCs (hcMSCs) were repeatedly transplanted intravenously on days 1 and 3 after SCI. Motor function and electrophysiological recovery of tcMEP were evaluated at 42 weeks post-transplantation. Tissue repair after SCI was assessed using immunostaining for myelin and neurons in the injured posterior cord.
Results
Repeated transplantation of hcMSCs significantly improved motor function and electrophysiological recovery than in single transplantation and control groups. In addition, this study reveals that repeated hcMSCs transplantation promotes electrophysiological functional recovery by exerting a protective effect on the functional structure of axons involved in the pyramidal tract.
Conclusions
Acute-phase repeated transplantation is expected to be a novel and effective therapeutic strategy for the clinical application of MSCs in SCI.
Health economics study of paliperidone palmitate in the treatment of schizophrenia: a 12-month cohort study
Authors: Luo Xing , Wang Jicai , Liu Fang , Lu Jin , Cheng Yuqi , Xu Xiufeng , He Xiaolin , Xia Yongbing , Gao Changqing , Xie Xian , Zhao Yu , Gao Chunqiang , Ding Hua , He Yuefei , Zhang Lifen , Zhang Xi , Song Jianhui , Yang Shunying , Liu Liming , Chen Wenming , Liu Wei , Luo Chuanlin , Pu Ensheng , Lei Ming , Wang Yan , Sun Zanzong , Yang Rucheng , Zhou Yong , Zhu Xianrong , Wang Bo , He Shuhua , Gao Donghua , LI Zhongcai , Huang Liqiong , Wang Tianlan , Yang Guangya , Liu Hong , Zhao Jinkun
Published: January 2024

Background
To analyze the economic benefits of paliperidone palmitate in the treatment of schizophrenia.
Methods
We collected 546 patients who met the diagnostic criteria for schizophrenia according to the 《International Statistical Classification of Diseases and Related Health Problems,10th》(ICD-10). We gathered general population data such as gender, age, marital status, and education level, then initiated treatment with paliperidone palmitate. Then Follow-up evaluations were conducted at 1, 3, 6, 9, and 12 months after the start of treatment to assess clinical efficacy, adverse reactions, and injection doses. We also collected information on the economic burden before and after 12 months of treatment, as well as the number of outpatient visits and hospitalizations in the past year to analyze economic benefits.
Results
The baseline patients totaled 546, with 239 still receiving treatment with paliperidone palmitate 12 months later. After 12 months of treatment, the number of outpatient visits per year increased compared to before (4 (2,10) vs 12 (4,12), Z=-5.949, P < 0.001), while the number of hospitalizations decreased (1 (1,3) vs 1 (1,2), Z = 5.625, P < 0.001). The inpatient costs in the direct medical expenses of patients after 12 months of treatment decreased compared to before (9026.00 ± 1918.60 vs 6301.58 ± 804.54, P < 0.05), while there was no significant change in outpatient expenses and direct non-medical expenses (transportation, accommodation, meal, and family accompanying expenses, etc.) (P > 0.05); the indirect costs of patients after 12 months of treatment (lost productivity costs for patients and families, economic costs due to destructive behavior, costs of seeking non-medical assistance) decreased compared to before (793.43 ± 155.20 vs 311.40 ± 54.22, P < 0.05).
Conclusion
Palmatine palmitate reduces the number of hospitalizations for patients, as well as their direct and indirect economic burdens, and has good economic benefits.
A ZP-OTFS-based Interleaved non-GB-OMA Method for Uplink Communication
Authors: Saeidi Ghasem , Saeedi-Sourck Hamid
Published: January 2024

This paper presents a non-guard band orthogonal multiple-access (non-GB-OMA) method that leverages orthogonal time frequency space (OTFS) modulation, an alluring technique for modern wireless communication. In an uplink scenario, to decrease the multi-user interference (MUI) induced by practical rectangular pulses, our method exerts a new interleaved approach to allocate non-overlapping delay-Doppler (DD) bins to the distinct user terminals (UTs) without any GB among them. A zero-padding (ZP) scheme is employed to cope more with the MUI and reduce the complexity of the data detection process. Additionally, we utilize subspace pursuit (SP), a compressed sensing technique, in conjunction with a unique pilot pattern extracted from the data frame structure for channel estimation. By preserving the estimation quality, this method can reduce the system's peak-to-average power ratio (PAPR) without necessitating an increase in pilot overhead. We also employ a two-stage feedback-oriented scheme to adapt the block linear-minimum mean square error (BL-MMSE) detector for data detection. Our method, which we evaluated through simulations, can provide notable results regarding the signal-to-noise ratio (SNR) and bit-error-rate (BER).
Elderly People Treated in Integrated Home Care in Italian Regions: A Metric Approach
Authors: Resta Onofrio , Resta Emanuela , Costantiello Alberto , Leogrande Angelo
Published: January 2024

In this article, we analyse the ESG determinants of the “Elderly People Treated in Integrated Home Care”-EPIHC in the Italian regions between 2004 and 2022. We used data from the ISTAT-BES database. We used different econometric techniques i.e.: Panel Data with Random Effects, Panel Data with Fixed Effects, Pooled Ordinary Least Squares-OLS and Weighted Least Squares-WLS. The results show that the EPIHC is positively associated with “Nurses, midwives, and Soil sealing by artificial cover" and negatively associated with "Museum heritage density and relevance" and "Trust in law enforcement agencies and firefighters fire". Furthermore, we have applied a k-Means algorithm with the Silhouette Coefficient and we find the presence of two clusters. Finally, we propose a confrontation among eight different machine-learning algorithms and we find that Linear Regression is the best predictive algorithm.
JEL CODE: I11, I12, I13, I14, I15, I18
Environmental Management Policies, Practices and Compliance with National and International Standards in the Eastern Industrial Park, Dukem Town, Ethiopia
Authors: Ayele Bekele Girma
Published: January 2024

An environmental policy is a written statement describing an organization’s mission in relation to environmental impacts of its operational activities. However, many industries of developing country fail to implement their environmental policy. The problem also manifested in certain Industrial parks of Ethiopia. Hence, this study intended to examine environmental management policies, practices and compliance in the Eastern Industrial Park of Dukem, Ethiopia. The study used qualitative approach using both primary and secondary data. On the other hand, purposive sampling was used to take the required sample. The target population of this study was the informants of selected government sectors and industries of Eastern Industrial Park. Structured interview question was designed to the informants. The qualitative data was analysed using thematic analysis. Tables, figures and charts were used for data presentation. Although industries in the industrial park had their own company environmental policy, however, there was limitation in documenting and implementing their environmental policy in their environmental management activities of the companies. The companies designed their policy merely to fulfil their requirement to the concerned authority. The findings revealed, the selected industries of Industrial Park not only fail to implement their policies but also limited in implementing the government and other international policies.
Ecological risk assessment and source tracing of heavy metals in surface sediments of a hilly riverine reservoir in Chongqing, China
Authors: Ao Liang , Chang Ruiting , Tang Yanqiu , Zhang Sheng
Published: January 2024

Background
This work conducted quantitative and qualitative analyses on the heavy metals in thirty-two surface sediment samples collected from eight sampling sites in Yutan reservoir, a typical mountainous hilly riverine reservoirin Southwest China across four seasons.
Results
Nine heavy metals were identified: (Cr, Cd, Pb, Cu, Zn, Hg, As, Ni and Co). The concentrations varied within the ranges of 23.16 ~ 34.62, 0.53 ~ 1.09, 31.88 ~ 59.04, 51.94 ~ 85.84, 106.76 ~ 227.69, 0.08 ~ 0.15, 12.57 ~ 25.60, 12.06 ~ 27.64, and 11.04 ~ 14.56 mg/kg respectively, following a decreased concentration order of Zn > Cu > Pb > Cr > Ni > As > Co > Cd > Hg. Except for the Cd, which accumulated in Winter, and Hg ,which reduced in Spring, the concentration of heavy metals showed no significant seasonal variation.The heavy metals generally had higher contents at the river mouth and lower concentrations in open water areas and branches. Igeo assessment indicated that the reservoir was uncomtamiated by Cr and Ni (Igeo<0), slightly polluted by Pb, Cu, Zn and Co(0 < Igeo<1), moderately polluted by Hg and As (1 < Igeo<2), and heavily polluted by Cd (1.44 < Igeo<2.48). The most polluted sites were at the river mouth, followed by the sediments in branches with slight pollution. Source tracing analysis revealed that Cr, Ni, Cd, Pb, Hg, As, OM, TN and TP were primarilyattributed to non-point sources, whereas Fe was linked to the hardware industry. Moreover, Al originated from sewage and drinking water treatment processes. The Cu and Zn were discharged from three components, indicating complex sources.
Conclusions
The findings underscored that non-point sources were the primary contributors to the increased risk of heavy metal contamination in the reserservior’s sediment. In addition, to effectively manage the risk and enhance the aquatic environment, greater focus should be placed on the inner load of heavy metals in the sediment of the mountainous hilly riverine reservoirs, particularly after controlling external pollution sources.
Realization of Superconducting- Magnetic Energy Storage Supported DSTATCOM Using DeepBayesian Active Learning
Authors: Mangaraj Mrutyunjaya , Nizami T K , Babu B Chitti , Muyen S M
Published: January 2024

The Distributed Static Compensator (DSTATCOM) is being recognized as a shunt compensator in the power distribution networks (PDN). In this research study, the superconducting magnetic energy storage (SMES) is deployed with DSTATCOM to augment the assortment compensation capability with reduced DC link voltage. The proposed SMES is characterized by a DC-DC converter with different circuit elements like one inductor, two diodes and two insulated gate bipolar transitors (IGBTs). The Deep Bayesian Active Learning (DBAL) algorithm is suggested to operate SMES supported DSTATCOM for the elimination of harmonics under different loading scenarios. Apart from this, the other benefits like improvement in power factor (PF), load balancing, potential regulation are attained. The simulation studies obtained from the proposed method demonstrates the correctness of the design and analysis compared to the DSTATCOM. To show the power quality (PQ) effectiveness, balanced and unbalanced loading are considered for the shunt compensation as per the guidelines imposed by IEEE-519-2017 and IEC- 61000-1 grid code.
Psilocybin-Assisted Therapy for Severe Alcohol Use Disorder: Protocol for a Double-Blind, Randomized, Placebo-Controlled, 7-month Parallel-Group Phase II Superiority Trial
Authors: Vanderijst Laetitia , Hever Felix , Buot Anne , Dauré Charles , Benoit Janaïna , Hanak Catherine , Veeser Johannes , Morgiève Margot , Campanella Salvatore , Kornreich Charles , Mallet Luc , Leys Christophe , Noël Xavier
Published: January 2024

Background: A significant number of individuals with alcohol use disorder remain unresponsive to currently available treatments, which calls for the development of new alternatives. In parallel, psilocybin-assisted therapy for alcohol use disorder has recently yielded promising preliminary results. Building on extant findings, the proposed study is set to evaluate the feasibility and preliminary clinical efficacy of psilocybin-assisted therapy when incorporated as an auxiliary intervention during inpatient rehabilitation for severe alcohol use disorder. Moreover, it intends to pinpoint the modifications in the two core neurocognitive systems underscored by dual-process models of addiction.
Methods: In this double-blind, randomized, placebo-controlled, 7-month parallel-group phase II superiority trial, 62 participants aged 21-64 years will be enrolled to undergo psilocybin-assisted therapy as part of a 4-week inpatient rehabilitation for severe alcohol use disorder. The experimental group will receive a high dose of psilocybin (30 mg), whereas the control group will receive an active placebo dose of psilocybin (5 mg), both within the context of a brief standardized psychotherapeutic intervention drawing from key elements of acceptance and commitment therapy. The primary clinical outcome is the between-group difference regarding the change in percentage of heavy drinking days from baseline to four weeks posthospital discharge, while safety and feasibility metrics will also be reported as primary outcomes. Key secondary assessments include between-group differences in terms of changes in 1) drinking behavior parameters up to six months posthospital discharge, 2) symptoms of depression, anxiety, trauma, and global functioning, 3) neuroplasticity and key neurocognitive mechanisms associated with addiction, and 4) psychological processes and alcohol-related parameters.
Discussion: The discussion outlines issues that might arise from our design.
Trial registration: EudraCT 2022-002369-14 and NCT06160232
The effect of USM-IAM-based counselling vs standard counselling on insulin adherence, FBS and HbA1c among patients with uncontrolled Type 2 Diabetes Mellitus (T2DM): A randomised controlled trial.
Authors: Zainudin Aida Maziha , Rasool Aida Hanum Ghulam , Yaacob Najib Majdi , Muhammad Rosediani , Mohamed Wan Mohd Izani Wan
Published: January 2024

Background: Many patients with T2DM on insulin are not optimally controlled despite receiving standard diabetes education counselling. Poor insulin adherence may be a contributing factor. We developed and evaluated a new module [USM-Insulin Adherence Module (USM-IAM)] on insulin-treated patients with poorly controlled diabetes.
Methods: Eligibility criteria are those diagnosed with T2DM, aged between 18 and 65 years, with HbA1c between 8 -15% and on insulin therapy for one year. Patients were randomly allocated to receive either the USM-IAM-based counselling or the standard counselling at baseline and the second visit. Patients were instructed to adjust insulin doses based on blood glucose levels. Outcomes were changes in adherence score, FBS and HbA1c levels from baseline to three months and baseline to sixth month.
Results: Ninety patients were randomised to each group. The baseline sociodemographic and clinical characteristics were homogenous among groups. Ninety patients were analysed for each group. Adherence score changes between baseline to three months were -8.30 (-11.47, -5.14) in UCG and -7.64 (-10.89, -4.40) in SCG, between baseline to sixth month were -10.21 (-13.40, -7.03) in UCG and -10.79 (-14.64, -6.97) in SCG. FBS changes between baseline to three months were 1.374 (0.25, 2.50) in UCG and 0.438 (-0.66, 1.54) in SCG, and between baseline to sixth month were 1.713 (0.473, 2.95) in UCG and 0.998 (-0.02, 2.01) in SCG. HbA1c changes between baseline to three months were 1.374 (0.25, 2.50) in UCG and 0.547 (0.12, 0.98) in SCG, and between baseline to sixth month were 1.03 (0.65, 1.41) in UCG and 0.617 (0.20, 1.03) in SCG.
Conclusion: Both groups had significant improvements in adherence score and HbA1c with time, with higher improvement in patients receiving the USM-IAM-based counselling. FBS reductions were significant in the intervention group but not in the control group.
Trial registration: This study protocol is registered with Clicaltrials.gov with ID NCT05125185 dated 17th November 2021.
Distribution and extent of suitable habitats of Prince Ruspoli turaco (Tauraco ruspolii) and White-cheeked turaco (Tauraco leucotis) in times of climate change in Ethiopia
Authors: Ayenew Mulatu , Kufa Chala Adugna , Ahmed Ahmed Seid , Tilahun Hailu , Tamrat Misganaw , Yihune Mesele , Atickem Anagaw , Bekele Afework , Bogale Bezawork Afework
Published: January 2024

Background
Understanding the distribution pattern of species and their suitable habitat is key to focus conservation effort. In the face of climate change, the extent of suitable habitats of species may affect over time thus, their survival and distribution. We aim to determine the distribution and extent of suitable habitats for Tauraco ruspolii and T. leucotis in Ethiopia and predict their range in 2050s and 2070s using MaxEnt algorithm. We used 25 and 29 rarified occurrence points for T. ruspolii and T. leucotis, respectively, and 13 environmental variables. Three regularization multipliers and two cut-off thresholds were used to map the potential suitable habitats for each species under current and future climates. Maps were assembled from these techniques to produce a final composite tertiary maps and investigated the habitat suitability overlap between the two species using the UNION tool in the geographical information system.
Result
All model run performances were highly accurate for both species. Precipitation of the driest month and vegetation cover are the most influential variables for the habitat suitability of T. ruspolii. The habitat suitability of T. leucotis is also mainly influenced by mean temperature of driest quarter and vegetation cover. Under the current climate, the suitable habitat predicted to T. ruspolii covered about 24639.19 km2, but its range size change shows gain and increase by 156.00% and 142.68% in 2050 and 2070, respectively. The T. leucotis‘s current suitable habitat ranges about 204397.62 km², but this is reduced by 40.84% and 68.67% in 2050 and 2070, respectively. Our modeling also showed that there was suitable habitat overlap between them at the margin of their respective habitat types in time series.
Conclusion
we concluded that there is a direct or indirect impact of climate change on the suitable habitat range expansion for T. ruspolii and contraction for T. leucotis as well as overlapping of these turaco species in different regions of Ethiopia. Therefore, understanding the distribution of current and future suitable habitats of the two turaco species can provide valuable information to implement conservation practices for the species and the regions as well.
Directed homology and persistence modules
Authors: Goubault Eric
Published: January 2024

We give a self-contained account on a construction for a directed homology theory based on modules over algebras, linking it to both persistence homology and natural homology. We study its first properties, among which relative homology and Mayer-Vietoris long exact sequences and a Kunneth formula.
What does the data analysis of 7,048 environmental articles tell us about the perception of Wikipedia's quality?
Authors: Petiška Eduard , Kuběna Aleš , Dressler Michal
Published: January 2024

Wikipedia is one of the most popular websites, and its role as the gateway to the world of information was especially important during the Covid-19 pandemic. However, its quest for objectivity is also valuable in other areas that are subject to ideological struggles, such as environmental issues. The quality of articles on these topics is important because they are used by students, journalists, and other actors; therefore, they have a significant impact on common knowledge. Wikipedia articles are included in different categories of quality, so we have analyzed all 7,048 environmental articles in the Environment Assessment project on English-language Wikipedia. Based on a review of literature, we have selected indicators of information quality (number of editors, edits and length of the article, number of references and word references ratio) and tested the correlation between these indicators and quality perception in the Wikipedia Assessment project. We have found that the articles perceived as having a higher quality have more editors and edits, are longer, have more references, and also more references to fewer words.
Positive Psychological Group Intervention for Non-suicidal self-injury Adolescents： A Pragmatic Randomized Controlled Trial
Authors: Yan Hu , RUI Zhao , YueGe Li , Han Kong , shuying Chang
Published: January 2024

Introduction:The effectiveness of Positive Psychological Group intervention (PPGI) in the treatment of non-suicidal self-injury (NSSI) remains to be explored.
Objective: Non-suicidal self-injury (NSSI) is prevalent among adolescents and associated with negative medical and psychological consequences, necessitating its treatment. However, few treatments have been developed to treat NSSI specifically or to treat the behavior among individuals without borderline personality disorder. The purpose of this study was to investigate the PPGI, a brief, behavioral intervention specifically developed to treat NSSI among adolescents, in a pilot randomized controlled trial (RCT).
Method: Forty adolescents meeting inclusion and exclusion criteria were randomly assigned to the treatment (PPGI; n = 20) or treatment as usual (TAU; n = 20) condition. The sample was 83.3% female, and 100% Asian. Our main results are the frequency of NSSI and the individual's positive and negative emotions. As secondary outcomes, we will assess changes in the sense of self-efficacy and growth mindset. Due to the subjectivity of scale measurement, this study will also use objective data such as functional Magnetic Resonance Imaging (fMRI) to measure the effect of intervention.
Results:After 6 weeks of intervention, the OSI score (P<0.001) and negative emotion score (P<0.001) in the PPGI group were significantly lower than those in the control group. Positive emotion scores (P<0.001), GSES (P<0.001), and GMS (P<0.001) were significantly higher than those in the control group. Functional Magnetic Resonance Imaging (fMRI) showed that brain function activity in the frontal lobe area was significantly lower than before the intervention (P<0.001). In addition, the control group also showed some effects in improving negative emotions.
Conclusion: Results of this study support the further evaluation of T-PPGI in a larger RCT.
Clinical Trial Registration: The trial was prospectively registered in the China Registry of Clinical Trial (https://www.chictr.org.cn/index.html; ChiCTR2400079412) and is now complete.
“Who Will Turn Me Away from the Sheep?”: Present State and Development Trends of Transhumant Pastoralism in Eastern Herzegovina in the 21st Century
Authors: Naumović Slobodan , Dražeta Bogdan
Published: January 2024

The paper presents the results of a field study of transhumant pastoralism which was carried out in June and July 2022 on the Zelengora, Volujak and Lebršnik mountains, on the Morine plateau, i.e. in the areas of the municipalities of Ljubinje, Nevesinje, Kalinovik and Gacko (Republic of Srpska-Bosnia and Herzegovina). The goal of the research was to determine the present state and development trends of transhumant pastoralism in the areas of eastern Herzegovina at the beginning of the 21st century. The paper gives an overview of the previous (ethnological) studies of transhumant pastoralism, and then presents the methodological procedures used in this research. The ethnographic section summarizes interviews with interviewees and field guides. The observed problems, both those that were talked about by the interviewees and those that were independently observed, were jointly expressed in the separate section as development trends that describe and at the same time shape the current state of transhumant pastoralism in the studied area. The problems in question are: the transformation of pastoralism into an individual economic strategy, and in some cases a form of personal leisure; changes in the directions and manner of livestock routes; the persistence of the basic production technology, along with the modernization of its individual elements; the weakening and dissolution of elements of the traditional cultural idiom; legal changes in property rights and the method of making compensations for rights of use; multiple consequences of war; increasingly pronounced neoliberal economic relations and withdrawal of the state; strengthening of personal motivation to engage in pastoralism; growing interest in zoological, ecological and climate topics. In almost all of the aforementioned trends, it is possible to recognize adaptation to the risks that come with changes in the environment, both natural and social. These are changes in the economy, demography, social relations, climate and ecology. The interviewees found ways to more or less successfully manage the mentioned risks.
Primary tuberculosis of the breast from mankweng hospital
Authors: Leso-Rangwato Leseilane Maureen , Bhuiyan Mirza M. Z. U.
Published: January 2024

Object of study: To share our experience with a rare case of Primary Tuberculosis of Breast.

The problem to be solved: Tuberculosis of the breast is a rare type of extrapulmonary tuberculosis and usually affects young lactating multiparous women. It accounts for less than 0.1 % of all breast pathologies. Tuberculosis of the breast is often misdiagnosed. Therefore, a high index of suspicion is needed when evaluating cases of breast abscesses, fistulae, or mass.

Main scientific results: A case of a 27-year-old female with no known co-morbidities, HIV negative who presented to our Surgical Outpatient Department with a 1-year history of a painless left breast lump. No previous history of pulmonary tuberculosis was reported. Breasts ultrasonography indicated BIRADS (Breast Imaging-Reporting and Data System) V: lesion highly suspicious of malignancy. Histopathological analysis of the core biopsy showed features of a necrotizing granulomatous mastitis with adjacent fat necrosis. Ziehl-Neelsen stain was negative though histological results were worrisome of a mycobacterial infection. Patient responded well to antitubercular therapy as evidenced by lump regression, ulceration healed, peau d’orage currently resolved, and the overall size of the breast is going back to its normal state.

The area of practical use of research results: Family medicine physicians, Primary health care center, District level or regional level hospital.

An innovative technological product: a high index of suspicion tuberculosis is needed when evaluating cases of breast abscesses, fistulae, or mass. Awareness of this condition is important as it can clinically, and radiologically mimic breast carcinoma.

Scope of application of an innovative technological product: Family medicine physicians, Primary health care center.
Study of loading of an improved container design during transportation by railway
Authors: Lovska Alyona , Dižo Ján , Pavliuchenkov Mykhailo , Rybin Andrij
Published: January 2024

The object of research. The object of research is the processes of occurrence, perception and redistribution of loads in the design of a container with a frame made of square pipes and lining made of smooth sheets.
Investigated problem. Under operating conditions, damage to containers may occur due to the loads acting on them during transportation by various modes of transport. One of the most determining among such loads are dynamic loads, which are experienced not only by the container structure, but also by the cargo placed in it. As a result, there may be damage to the structure of the container, as well as to the cargo, which necessitates additional costs, both for the repair of containers and for reimbursement of expenses for damage to the transported cargo. In addition, this situation is unfavorable from an environmental point of view. In this regard, there is a need to conduct research to improve the design of a universal container in order to reduce its load, as well as increase operational efficiency.
The main scientific results. A scientific substantiation of the use of square pipes as components of the frame of a universal container has been carried out.
The area of practical use of research results. The sphere of practical use of the obtained results is the engineering industry, in particular railway transport.
Innovative technological product. The concept of a universal container with a frame made of square pipes and a lining made of smooth sheets.
Scope of the innovative technological product. The developments proposed as part of the study will be useful recommendations for creating innovative vehicle designs, including modular ones.
Yavaş Şehir Güdül ün Turizm Potansiyelinin Değerlendirilmesi (Evaluation of The Tourism Potential of Cittaslow Güdül)
Authors: EŞİYOK Halime , ÖZTÜRK Yüksel
Published: January 2024

Cittaslow (yavaş şehir), kültürel değerleri yöresel seviyede ileten ve yaşam biçiminde yavaşlığı özendiren sosyal bir eylem ve organizasyon olarak ifade edilebilir. Cittaslow destinasyonları, insanlar, mekânlar ve kaynaklar arasındaki etkileşimleri özendirerek eşsiz niteliklerini korumayı, yerleşiklerin ve ziyaretçilerin yaşam kalitesini iyileştirmeyi amaçlamaktadır. Bu tür savunuculuk sayesinde, katılımcı destinasyonlar artan ilgiyi çekmektedir. Söz konusu hareket, turizm araştırmalarında yer bağlılığına yönelik artan ilgiyle paralellik göstermektedir. Araştırma alanı olarak İç Anadolu Bölgesi ve Ankara’nın ilk Cittaslow’u olan Güdül ilçesi seçilmiştir. Çalışmanın amacı, Cittaslow bağlamında Güdül ilçesinin turizm potansiyelini incelemektir. Bu amaç doğrultusunda sertifikalı bir destinasyon için turizm potansiyeli, hizmet aktörlerinin (kamu, STK, özel işletmeler) bakış açıları ile değerlendirilmiştir. Araştırmada nitel veri toplama tekniklerinden biri olan görüşme tekniği kullanılmıştır. Bulgular, toplum ortamı ve yönetim hizmeti, kültürel kaynaklar ve değerler, doğal kaynaklar ve koruma olmak üzere çeşitli boyutları ortaya çıkarmaktadır. Mevcut çalışmada, yavaş turizm destinasyonu olarak Güdül’ün daha iyi planlanması ve yönetilmesinde doğal, kültürel ve yerel bileşenlerin entegre edilmesi önerilmektedir.
Bursa Yemek Kültürü Üzerine Nitel Bir Araştırma (A Qualitative Research on Bursa Food Culture)
Authors: YILMAZ İlkay , DOĞAN Sena Nur
Published: January 2024

Bursa mutfağı, farklı kültürlerin getirdiği beslenme alışkanlıkları ve kendi coğrafi zenginliklerinden doğmuş köklü bir mutfaktır. Bu çalışmada, Bursa yeme içme kültürünü belirlemek, Bursa mutfak kültürüne ait geleneksel yemeklerin ortaya çıkarılması ve yöreye özel uygulamaların belirlenmesi amaçlanmış ve görüşmeler yapılarak kültürel miras kayıt altına alınmaya çalışılmıştır. Çalışmada durum çalışması deseni kullanılmıştır. Çalışmanın evrenini Bursa’da yaşayan kişiler, örneklemini ise Orhaneli, Keles, Harmancık, Kestel, Osmangazi ilçelerinde yaşayan Bursa doğumlu ve hâlâ orada yaşamakta olan 12 kişi oluşturmaktadır. Amaçlı örnekleme yöntemlerinden kartopu örneklemesi kullanılmıştır. Nitel araştırma yöntemlerinden biri olan görüşme tekniği kullanılmış ve yarı yapılandırılmış görüşmelerle veriler toplanmıştır. Verilerin çözümlenmesinde içerik analizinden yararlanılmıştır. Sonuçlara göre, tariflerin gelecek kuşaklara aktarılması konusunda katılımcılar, ailelere büyük görev düştüğü konusunda hemfikir olmuşlardır. Bursa yöresel yemeği adı altında 12 adet çorba, 60 adet ana yemek, 24 adet hamur işi, tatlı ve içecek ismine ulaşılmış ve reçetesine ulaşılan 11 yemek ile tatlı da, tarifler kısmına alınarak makaleye eklenmiştir. Coğrafi işaret bilgisi ve kullanması ile ilgili sorulara verilen yanıtlar bu konuda bilgilendirilmeye ihtiyaç olduğunu göstermektedir. Sonuç olarak, Bursa mutfağının korunması ve yaşatılması için ailelerin, eğitim kurumlarının ve kamu kurumlarının iş birliği içinde çalışmalar yapması gerekmektedir. Bu çalışmalar kapsamında da Bursa mutfağı ile ilgili akademik çalışmalara ağırlık verilmelidir.
Analysis of Sales Promotion and Influence of Corporate Social Responsibility for Brand Image and Its Impact to Usage Behavior of BNI Credit Cards
Authors: Rahardja Alexius
Published: January 2024

In this modern era, credit cards are not only payment but also lifestyle for some people. The use of credit cards cannot be separated from the promotion that is given by the bank. In addition, CSR is mandatory for every company as a social responsibility to the environment. CSR itself is useful to create a positive image of the industry or institution brand. This study analyzed the effect of Sales Promotion and CSR to Usage Behavior through Brand Image as a mediator in Bank BNI. The purpose of this study is to look at the effects produced between variables by using path analysis so that BNI can increase strategy in its efforts to increase the use of credit cards.
Analysis of The Influence of Brand Experience, Brand Communication, Brand Trust, And Satisfaction On Brand Loyalty
Authors: Francis Putra Vincentius
Published: January 2024

The purpose of this research is to know the influence of Brand experience, Brand Communication, Brand Trust, and satisfaction of Brand Loyalty in Ardiles case study in D.I Yogyakarta. The population of this study is consumers of shoes and sandals Ardiles who have bought in pantes shop. This study uses the SEM-PLS method to measure the relationship and influence between variables in the study who have Brand experience that affect each other on brand brand but the brand experience has no significant effect on Brand Loyalty.
Guerra às drogas e ideologia: a indústria ilegal de cocaína pelas lentes cinematográficas
Authors: Góes Jefferson Vieira de , Paes Lígia Ranara Rocha , Ferraz Deise Luiza da Silva
Published: January 2024

Objetivo: Identificar o discurso ideológico sobre o narcotráfico nas Américas expresso pelos documentários e os valores que, a partir deles, são aceitos como representação do real. Método: Realizamos a análise fílmica (Medina, 2020) de quatro documentários produzidos de 2017 a 2020, disponíveis na plataforma de streaming Netflix, que abordam a indústria ilegal de coca-cocaína no continente americano. Marco Teórico: A partir de Mészáros (2004), compreendemos que o sistema ideológico dominante apresenta as regras pelas quais os seres humanos compreendem, lidam e atuam no mundo visando resolver os conflitos sociais. Resultados: Nos filmes, a relação entre o grande consumo de drogas nos EUA e a respectiva produção nos países latinos se constitui a partir da produção de dois imaginários antagônicos: um imaginário positivo sobre os EUA e outro negativo sobre os países latinos envolvidos no tráfico de drogas, que se desdobram na constituição da tríade vítima-vilão-herói que legitima o consentimento comum de intervenções americanas na guerra contra as drogas e suas vítimas, a despeito da nacionalidade destas. Conclusões: A seletividade na representação acerca da aparência do fenômeno do narcotráfico nos diferentes países demonstra uma dicotomia favorável à ordem capitalista, reproduzindo uma subjetividade coletiva fetichizada que obstaculiza a consciência de classe.
Relações que afetam a satisfação no teletrabalho domiciliar
Authors: Brito Claiton Pimentel de , Bastos Sérgio Augusto Pereira
Published: January 2024

A pandemia da COVID-19 forçou a adoção do teletrabalho domiciliar como alternativa à viabilização das operações de várias empresas, o que implicou adequações nos modelos de gestão. Assim, o objetivo deste artigo é identificar as relações entre estilos de liderança - transacional e transformacional, clima organizacional, satisfação do teletrabalhador e incivilidade do gestor no contexto do trabalho domiciliar, no curto prazo e, potencialmente, no longo prazo. A pesquisa é quantitativa com uso modelagem de equações estruturais estimadas por mínimos quadrados parciais. Os resultados mostram que ambos os estilos de liderança e o clima organizacional impactam positivamente a satisfação do teletrabalhador. Adicionalmente, o clima organizacional medeia parcialmente as relações entre estilos de liderança e satisfação do teletrabalhador. No entanto, o efeito moderador da incivilidade não é confirmado. Com isso, contribui-se com a organização em teletrabalho domiciliar total ou parcial, uma tendência pós-pandemia ou em novas situações semelhantes. Por meio da perspectiva da Teoria do Ajuste, destaca-se a relação entre os construtos estudados em um contexto virtual, o que contribui para o campo de estudos de gestão de pessoas.
Competência informacional com vistas à mulher em situação de violência
Authors: Neri Georginei Souza , Mota Francisca Rosaline Leite
Published: January 2024

A violência contra a mulher é uma realidade mundial estabelecida nas desigualdades de gênero e perpetuada por discursos culturais e sociais. O acesso e uso de informações precisas e atualizadas sobre diferentes formas de violência são fundamentais para romper o ciclo de agressão e da falta de conhecimento sobre direitos e leis de proteção. Nesta perspectiva, é mister entender o comportamento informacional e fomentar a Competência Informacional das mulheres vítimas da violência de gênero.  O presente artigo se propõe a tecer considerações sobre as deficiências sociais, políticas e operacionais existentes na esfera de amparo e proteção às mulheres vítimas de violência (s). Como resultado, propõe a construção de um modelo de rede pautado na intersecção mulher-informação-órgãos de apoio e proteção contra à(s) violência(s), fundamentada nas competências em informação de modo concomitante.
RECURSOS INFOCOMUNICACIONAIS PARA APRENDIZAGEM ORGANIZACIONAL
Authors: Finamor Márcio da Silva , Silva Davi Jose de Souza da
Published: January 2024

Este artigo propõe avançar na promoção da aprendizagem organizacional por meio da integração dos processos e recursos dentro do ambiente organizacional. Para isso, é necessário considerar tanto as características intrínsecas de aprendizagem do ser humano, bem como as informações, conhecimentos, aspectos sociais e quanto aos processos e fatores organizacionais que influenciam na aprendizagem, como a prática dialógica reflexiva, liderança e memória organizacional. Com objetivo de verificar a evolução da literatura de aprendizagem com a utilização e reutilização dos recursos da empresa como todas as capacidades, processuais e atributos sociais, que constituem ativos tangíveis e intangíveis. Seguindo os passos de uma revisão crítica da literatura proposta por (Wright and Michailova, 2022) utilizando fontes de evidências, reunindo e fornecendo informações ricas para provocações construtivas. Por fim, apresentamos uma proposta teórico-metodológica de aprendizagem infocomunicacional a ser aprofundada, como fator valioso nas organizações que devem ser pensadas em sua totalidade, pois são recursos relevantes por serem características inerentes ao ser humano e às estruturas organizacionais.
Association of Cystatin C Level with All-cause Mortality in Patients
with Liver Cirrhosis: A Meta-analysis
Authors: Wang Xiaoyan , Xu Wei , Yao Lin , Jie Yu , Gao Zhenjun , Fan Yu
Published: January 2024

Background and Objective::

Blood cystatin C level has been introduced as a
promising biomarker to detect early kidney injury in cirrhotic patients. The purpose of
this meta-analysis was to investigate the association of blood cystatin C level with allcause
mortality in patients with liver cirrhosis.

Methods::

PubMed, ScienceDirect, and Embase databases were searched from the inception
to November 15, 2022. Observational studies evaluating the value of blood cystatin
C level in predicting all-cause mortality in patients with ACS were selected. The pooled
hazard risk (HR) with 95% confidence intervals (CI) was calculated using a random effect
model meta-analysis.

Results::

Twelve studies with 1983 cirrhotic patients were identified. The pooled adjusted
HR of all-cause mortality was 3.59 (95% CI 2.39-5.39) for the high versus low group
of cystatin C level. Stratified analysis by study design, characteristics of patients, geographical
region, sample size, and length of follow-up further supported the predictive
value elevated cystatin C level.

Conclusion::

Elevated cystatin C level was an independent predictor of poor survival in
patients with liver cirrhosis. Detection of blood cystatin C level may provide important
prognostic information in cirrhotic patients.
Identification of Crosstalk Genes between Lung Adenocarcinoma and Periodontitis
Authors: Wang Pengcheng , Yu Hui , Gao Xiaoli , Guo Ziyi , Zhang Zheng , Wang Zuomin
Published: January 2024

Background:

Lung adenocarcinoma (LUAD) represents a significant global
health issue. Smoking contributes to the development of periodontitis and LUAD. The
connections between the two are still ambiguous.

Methods:

Based on RNA expression data from The Cancer Genome Atlas (TCGA) and
Gene Expression Omnibus (GEO) databases, differentially expressed genes (DEGs) in
Periodontitis and LUAD were collected. Protein-protein interaction (PPI) networks were
produced by mining genes intersecting with crossover DEGs. Genes in the subnetwork
and the top 15 genes of the topology score were defined as the crosstalk gene. Feature selection
and diagnostic model construction were conducted based on Recursive Feature
Elimination (RFE) and support vector machines (SVM). additionally, we analyzed the
immune cells and signaling pathways influenced by the crosstalk gene.

Results:

A total of 29 crossover DEGs between Periodontitis and LUAD were filtered,
with 20 genes interacting with them in the PPI network. Five subnetworks with similar
interaction patterns in the PPI network were detected. Based on the network topology
analysis, genes ranking in the top 15 were used to take the intersection with those genes
in the 5 subnetworks. Twelve intersecting genes were identified. Based on RFE and
SVM algorithms, FKBP11 and MMP13 were considered as the Crosstalk genes for both
Periodontitis and LUAD. The diagnostic model composed of FKBP11 and MMP13
showed excellent diagnostic potential. In addition, we found that FKBP11 and MMP13
influenced Macrophages, M1, T cells, CD8 activity, immune-related pathways, and cell
cycle pathways.

Conclusion:

We identified the crosstalk genes (FKBP11 and MMP13) between periodontitis
and LUAD. The two genes affected the comorbidity status between the two diseases
through immune cell activity.