bluuebunny/crossref_metadata_2025 huggingface dataset:
Algorithmic Processes of Social Alertness and Social Transmission: How Bots Disseminate Information on Twitter
Authors:   University of Georgia, Salge Carolina , Karahanna Elena , Thatcher Jason ,   Temple University
Published: May 2022

Despite increased empirical attention, theory on bots and how they act to disseminate information on social media remains poorly understood. Our study leverages the conduit brokerage perspective and the findings of a multiple case study to develop a novel framework of algorithmic conduit brokerage for understanding information dissemination by bots and the design choices that may influence their actions. Algorithmic conduit brokerage encompasses two intertwined processes. The first process, algorithmic social alertness, relies on bot activity to curate and reconfigure information. Algorithmic social alertness is significant because it involves action triggers that dictate the kinds of information being searched, discovered, and retrieved by bots. The second process, algorithmic social transmission, relies on bot activity to embellish and distribute the information curated. Algorithmic social transmission is important because it can broaden the reach of information disseminated by bots through increased discoverability and directed targeting. The two algorithmic conduit brokerage processes we offer are unique to bots and distinct from the original conceptualization of conduit brokerage, which is rooted in human activity. First, since bots lack the human ability of sensemaking and are instead fueled by automation and action triggers rather than by emotions, algorithmic conduit brokerage is more invariant and reliable than human conduit brokerage. Second, automation increases the speed and scale of information curation and transfer, making algorithmic conduit brokerage not only more consistent but also faster and more extensive. Third, algorithmic conduit brokerage includes a set of new concepts (e.g., action triggers and rapid scaling) that are specific to bots and therefore not applicable to human conduit brokerage.
Heterogeneous Demand Effects of Recommendation Strategies in a Mobile Application: Evidence from Econometric Models and Machine-Learning Instruments
Authors:   Emory University, Adamopoulos Panagiotis , Ghose Anindya ,   New York University, Tuzhilin Alexander ,   New York University
Published: May 2022

In this paper, we examine the effectiveness of various recommendation strategies in the mobile channel and their impact on consumers’ utility and demand levels for individual products. We find significant differences in effectiveness among various recommendation strategies. Interestingly, recommendation strategies that directly embed social proofs for the recommended alternatives outperform other recommendations. In addition, recommendation strategies combining social proofs with higher levels of induced awareness due to the prescribed temporal diversity have an even stronger effect on the mobile channel. We also examine the heterogeneity of the demand effect across items, users, and contextual settings, further verifying empirically the aforementioned information and persuasion mechanisms and generating rich insights. We also facilitate the estimation of causal effects in the presence of endogeneity using machine-learning methods. Specifically, we develop novel econometric instruments that capture product differentiation (isolation) based on deeplearning models of user-generated reviews. Our empirical findings extend the current knowledge regarding the heterogeneous impact of recommender systems, reconcile contradictory prior results in the related literature, and have significant business implications.
How Do Organizations Learn from Information System Incidents? A Synthesis of the Past, Present, and Future
Authors:   Vrije Universiteit Amsterdam, Rezazade Mehrizi Mohammad H. , Nicolini Davide ,   University of Warwick, Rodon Joan ,   Universitat Ramon Llull
Published: May 2022

We review the literature on how organizations learn from information system (IS) incidents. We identify three modes of learning depending on the practices that constitute the learning process, the specific actors who play roles in learning, the temporal orientation of the learning practices, and the specific contextual focus of the learning. The literature focuses primarily on learning from past experience to draw lessons for future incidents (reflective learning mode). Yet, a growing stream of literature stresses the importance of learning through engagement with present incidents (embedded learning mode), and a few studies suggest that organizations can learn prospectively to prepare for future incidents (prospective learning mode). We argue that although these three learning modes are effective, they do not adequately explain how organizations learn from IS incidents when used in isolation. Since IS incidents unfold increasingly as sets of interacting events across information systems and organizational settings, organizational learning needs to be theorized as an iterative process among these learning modes. We synthesize these three learning modes into an integrative framework and theorize about their supportive and inhibiting relations. We suggest some opportunities for future research, which would advance our understanding of how organizations learn from IS incidents.
Managing Collective Enterprise Information Systems Compliance: A Social and Performance Management Context Perspective
Authors:   Renmin University of China, Zhou Jingmei , Fang Yulin ,   The University of Hong Kong, Grover Varun ,   University of Arkansas
Published: May 2022

In today’s environment characterized by business dynamism and information technology (IT) advances, firms must frequently update their enterprise information systems (EIS) and their use policies to support changing business operations. In this context, users are challenged to maintain EIS compliance behavior by continuously learning new ways of using EIS. Furthermore, it is imperative to businesses that employees of a functional unit maintain EIS compliance behavior collectively, due to the interdependent nature of tasks that the unit needs to accomplish through EIS. However, it is particularly challenging to achieve such a collective level of EIS compliance, due to the difficulty that these employees may encounter in quickly learning updated EIS. It is, therefore, vital for firms to establish effective managerial principles to ensure collective EIS compliance of a functional unit in a dynamic environment. To address this challenge, this study develops a research model to explain collective EIS compliance by integrating theoretical lens on social context and performance management context with social capital theory. It proposes that social context, an organizational environment characterized by trust and support, positively affects collective EIS compliance by developing business–IT social capital that enhances mutual learning between business and IT personnel. Furthermore, the performance management context, an organizational environment characterized by discipline and “stretch,” is seen to have a direct and beneficial effect on collective EIS compliance as well as an indirect, moderating effect on the causal chain among social contexts, business–IT social capital, and collective EIS compliance. General empirical support for this research model is provided via a multiple-sourced survey of managers and employees of 159 functional units of 53 firms that use EIS, as well as their corresponding IT unit managers. The theoretical and practical implications of these findings are discussed.
Nelfilcon A, a New Material for Contact Lenses
Authors: Bühler Niklaus , Haerri Hans-Peter , Hofmann Manfred , Irrgang Christine , Mühlebach Andreas , Müller Beat , Stockinger Friedrich
Published: May 2022

The synthesis and the purification of a new photo-crosslinkable poly(vinyl alcohol), Nelfilcon A, is briefly reviewed in this paper. Methods for the attachment of different functional groups to the polymer backbone are described. From the Nelfilcon A macromer, Focus® Dailies™ contact lenses are produced with a new production technology.
From FKBP12 to IMPDH: Ten Years of Immunology Targets at Vertex
Authors: Murcko Mark
Published: May 2022

No abstract.
Les sciences de la vie dans la HES-SO. La contribution de l'Ecole d'ingénieurs du Valais
Authors: Besse Jacques
Published: May 2022

Man at the end of this millennium looks for products that improve his health and his well-being. He thus expects science and research to offer him such improvements in the quality of life. The Engineering School of Valais has decided to take on this challenge by bringing into the fore the engineering and life sciences that are the core activities of its two departments, Chemistry and Food Technology & Biotechnology. Their complementarity and the pooling together of their human and material resources within a single Competence Group generate exceptionally large synergies both at the teaching and at the R&D level. As far as the latter is concerned, the strategy focuses on two main areas:– the chemistry of natural substances and products;– the authenticity, quality, and safety of foodstuffs.Through this Competence Group, which comprises over 20 researchers who can count on the support of 15 technicians, the Engineering School of Valais becomes a full-blown partner for new challenges in the life sciences.
Capillary Electrochromatography – Challenges and Opportunities for Coupling with Mass Spectrometry
Authors: Luedtke Silke , Unger Klaus K.
Published: May 2022

Capillary electrochromatography (CEC) has attracted considerable interest within recent years because of its potential to generate very high efficiencies within relatively short analysis time. Since CEC combines the attributes of both capillary electrophoresis (CE) and high-performance
liquid chromatography (HPLC), neutral as well as charged analytes can be separated. Usually, CEC is performed with UV detection, but mass spectrometry (MS) is becoming a more common detection method because additional information about the molecular weight and the structure of an analyte can
be obtained. Due to the low flow rates in the packed capillary and the small sample amounts that are required, CEC is ideally suited for the implementation into miniaturized systems and for coupling with MS. While numerous advantages have been made in CEC/MS, the coupling technique is still
in a development and growth stage. So far, the development of the technique seems to be limited by the lack of robust and automated specially designed CEC instruments and CEC interfaces. As soon as these practical constraints have been solved, CEC/MS will be a powerful separation/detection
technique with unrivaled sensitivity and specifity. This article aims at highlighting the potential of CEC as coupling technique with mass spectrometry.
THE PROBLEM OF PRODUCTION AND CONSUMPTION WASTE MANAGEMENT ON THE TERRITORY OF VORONEZH REGION
Authors: Скоробогатова Л.Г. , Агеев В.В. , Щербаков В.М. , Дубова С.М.
Published: May 2022

В настоящей статье приведена информация по динамике размещения отходов производства и потребления в Воронежской области, рассмотрена территориальная схема обращения с отходами на территории Воронежской области. Освещены проблемы утилизации отходов и рассмотрены возможные пути их решения.

This article provides information on the dynamics of production and consumption waste disposal in the Voronezh region, considers the territorial scheme of waste management in the Voronezh region. The problems of waste disposal are highlighted and possible ways of their solution are considered.
OPTIMIZATION OF MECHANIZED EXTRACTION AT LOW-YIELD FUND OF OIL AND GAS FIELDS
Authors: Гаджиев М.Д. , Стрекалов А.В.
Published: May 2022

В условиях кратного снижения мировых цен на нефть добыча нефти из малодебитных обводненных скважин становится нерентабельной. Выбор механизированной насосной установки для подъема продукции из малодебитных скважин вызывает много сложностей у предприятий ТЭК. Предпочтения для эксплуатации подобных скважин отдано таким традиционным технологиям, как УЭЦН, СШНУ, ВШНУ, УЭФН и др. Однако, эксплуатация скважин такими установками сопровождаются характерными недостатками. Это приводит к сокращению срока службы работы установок, увеличивая экономические потери конкретных предприятий.

Under the conditions of a multiple decline in world oil prices, oil production from marginal flooded wells becomes unprofitable. The choice of a mechanized pumping unit for lifting products from marginal wells causes many difficulties for fuel and energy companies. Preference for the operation of such wells is given to such traditional technologies as ESP, SShNU, VSHNU, UEPN, etc. However, the operation of wells with such installations is accompanied by characteristic disadvantages. This leads to a reduction in the service life of installations, increasing the economic losses of specific enterprises.
Between grammar and conversation : On the well-formedness of beat clashes in natural conversation
Authors: Uhmann Susanne
Published: May 2022

This paper deals with the interplay between grammar and conversation. This will be exemplified by a rhythmical phenomenon that has been described as beat clash in metrical phonology. In metrical phonology beat clashes are regarded as highly marked or even deviant rhythmical structures because the phonologically unmarked alternation between prominent and non-prominent syllables is cancelled in favour of a succession of prominent syllables. It will be shown that participants in natural conversation not only let beat clashes happen, but that beat clashes are actively constructed by turning non-prominent syllables into prominent ones. But these achieved beat clashes seem to be restrained by sequential and grammatical constraints: they occur in extended first assessments like stories, news or informings and in seconds to these conversation objects, but they are absent in first and in second assessments of assessment pairs; they respect the prominence structure which is the result of grammatical rules.
Myrtus communis L. Ellagitannins and Flavonoids Protect Cardiomyoblast Cells against CoCl2 -Induced Hypoxia and H2 O 2 Stress by Improving Oxidative Balance
Authors:   Laboratory of Aromatic and Medicinal Plants, Centre of Biotechnology of Borj-Cedria, BP 901, 2050 HammamLif, Tunisia, RB Mansour , W Megdiche-Ksouri ,   Laboratory of Aromatic and Medicinal Plants, Centre of Biotechnology of Borj-Cedria, BP 901, 2050 HammamLif, Tunisia, N Nefzi ,   Laboratory of Aromatic and Medicinal Plants, Centre of Biotechnology of Borj-Cedria, BP 901, 2050 HammamLif, Tunisia, S Bourgou ,   Laboratory of Aromatic and Medicinal Plants, Centre of Biotechnology of Borj-Cedria, BP 901, 2050 HammamLif, Tunisia, R Ksouri ,   Laboratory of Aromatic and Medicinal Plants, Centre of Biotechnology of Borj-Cedria, BP 901, 2050 HammamLif, Tunisia, M-A Giroux-Metgès ,   Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé, EA 4324 Laboratoire de Physiologie ORPHY, 29200 Brest, France, H Talarmin ,   Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé, EA 4324 Laboratoire de Physiologie ORPHY, 29200 Brest, France
Published: May 2022

This study evaluates the potential protective effect of Myrtus communis leaves buthanolic fraction (MBF) on CoCl2 and H2 O2 -challenged H9c2 cardiomyoblast cells. The identification of the main compounds by LC-ESITOF-MS was assessed. Among the 23 identified molecules (12 ellagitannins, 8 flavonoids, 1 coumarins, 1 anthocyanin and 1 myrtucommulone), 6 have been described for the first time in M. communis. The MBF displayed high amount of total phenolic (151.09mg of GAE/g of DR), flavonoid and tannin contents (21.81 and 49.54 mg of CE/g of DR, resp.) related to its important antioxidant activity such as DPPH (IC50 = 3.3μg/mL) and ABTS (IC50 = 14μg/mL) tests. Otherwise, exposure of cultured H9C2 cells to CoCl2 -simulated hypoxia or H2 O2 -oxidative stress induced over-activity of superoxide dismutase (over 181 %) and Catalase (171 and 500 %, resp.) and decrease in glutathione peroxidase (≈ 48 %) and excess in MDA (≈ 300 %) level. Pretreatment with MBF, attenuated significantly CoCl2 and H2 O2 challenged cardiomyoblasts injury by restoring cell viability (≈ 100 %), oxidative balance and MDA level. These results indicate that WBF can be used as a functional food to reduce the side effects of the oxidative stress and can be therapeutically effective candidate in cardiac ischemic injuries.
On the problems of monitoring the shadow economy
Authors: Baturina E. V.
Published: May 2022

The article presents the main provisions of the author’s Concept of monitoring the shadow economy through the economic and mathematical analysis of the shadow cashless cash flow. According to the author’s concept, the object of shadow economy monitoring has been specified, priority areas of shadow economy monitoring have been outlined, the tasks of ensuring economic security of the Russian Federation have been revealed. The necessity (relevance) of implementing the author's Concept has been substantiated: the disadvantages of existing methods of shadow economy assessment have been outlined and the advantages of the proposed author’s scientific approach allowing to minimise the above disadvantages have been presented. The result of a critical analysis of the shortcomings of the scientific idea itself has been presented and the further research directions have been determined.
Container traffic: East African case
Authors: Golubeva V. S. , Shcherbinin N. V.
Published: May 2022

The article reveals the historical features of foreign trade and its transport support in the East African region. In the course of the study an analysis of the export-import cargo flows structure in East Africa both in the colonial period and at the present time has been carried out. The region infrastructure facilities, including seaports, have been considered, their attractiveness for investments and doing business has been taken into account. The current level of container line service for providing the foreign economic transactions transport component has been shown and the main East African ports by level of line service and container turnover have been identified. The main problems and opportunities for increasing East African trade supplies and their logistics services have been revealed.
Distributed teams: challenges and opportunities
Authors: Orlova M. V. , Aleksandrova I. Yu.
Published: May 2022

A  geographically dispersed workforce poses new challenges for managers, which shift the focus from project management to managing distributed project teams. Adapting the company and its management to this evolution in the workplace, it is necessary to create an  environment in which remote team members interact productively. Distributed work requires operational flexibility from companies, which is characterised by  greater susceptibility to changes in their markets, to new emerging customer requirements and new competitive threats. The article is devoted to the identification of factors contributing to the transition of companies to the distributed workforce, the advantages of this type of work, and the difficulties that companies will face.
Variants, structure and value chain management algorithm
Authors: Tyapukhin A. P.
Published: May 2022

The research purpose is to clarify and supplement the Value Chain Management theory and methodology by substantiating its main variants, improving the terminological apparatus and improving the relationships between the links of this chain. Classification methods, analysis and synthesis, induction and deduction were chosen as research methods, and binary matrices formed on the basis of classification attributes and their dichotomies were used as the research tool. The article states the following new results: the necessity of studying the term “value life cycle”; proposes directions for improving the “Management by value” concept in relation to chains in statics and dynamics; develops forms classifications for obtaining value by the consumer and supplier and Value Chain Management objects; and also develops the algorithm for creating consumer and supplier values. The obtained results make it possible to reduce the lost profit of the links in value chain due to the functions rational distribution, powers, performers’responsibility and eliminating organisational barriers on the flows trajectories of various value forms and related resources.
Impact of Industry 4.0 on the economy and production
Authors: Mezina T. V. , Zozulya A. V. , Zozulya P. V. , Chernova T. F. , Pletnyova A. V.
Published: May 2022

The difficulties and problems faced by economic entities, countries and regions, in general, on the way to implementing the achievements and developments of Industry 4.0 have been designated in the article. Special attention has been paid to economic and production aspects, as well as changes in the relevant systems in the context of radical technological transformations. In particular, it has been established that markets are becoming oligopolistic, the role and importance of medium and small businesses is significantly increasing, the problems of social inequality and tension in connection with growing unemployment and the need for highly qualified personnel are becoming more acute. In addition, the features of competition for technologies, investments, sales markets, territories of productive forces location have been highlighted. Attention has also been focused on the main “revolutionary” trends in industrial development associated with the launch of the innovation and technological cycle initiated by “Industry 4.0”. Specific actions and measures have been identified to implement these trends into reality.
Elucidation of Complex Triplet Excited State Dynamics in Pd(II) Biladiene Tetrapyrroles
Authors: Martin Shea , Repa Gil , Hamburger Robert , Pointer Craig , Ward Kaytlin , Pham Trong-Nhan , Martin Maxwell , Rosenthal Joel , Fredin Lisa , Young Elizabeth
Published: May 2022

Pd(II) biladienes have been developed over the last five years as non-aromatic oligotetrapyrrole complexes that support a rich triplet photochemistry. In this work, we have undertaken the first detailed photophysical interrogation of three homologous Pd(II) biladienes bearing different combinations of methyl- and phenyl-substituents on the frameworks’ sp3-hybridized meso-carbon (i.e., the 10-position of the biladiene framework). These experiments have revealed unexpected excited-state dynamics that are dependent on the wavelength of light used to excite the biladiene. More specifically, transient absorption spectrosco-py revealed that higher-energy excitations (exc ~ 350-500 nm) led to an additional lifetime (i.e., an extra photophysical pro-cess) compared to experiments carried out following excitation into the lowest-energy excited states (exc = 550 nm). Each Pd(II) biladiene complex displayed an intersystem crossing lifetime on the order of tens of ps and a triplet lifetime of ~20 s, regardless of the excitation wavelength. However, when higher-energy light is used to excite the complexes, a new life-time on the order of hundreds of ps is observed. The origin of the ‘extra’ lifetime observed upon higher energy excitation of the Pd(II) biladiene complexes was revealed by detailed computational modeling using density functional theory (DFT) and time-dependent DFT (TDDFT). These efforts demonstrated that excitation into higher-energy metal-mixed-charge-transfer excited states with high spin-orbit coupling to higher energy metal-mixed-charge-transfer triplet states leads to the additional excitation deactivation pathway. Importantly, time-resolved spectroscopy and electronic structure calculations carried out for the analogous aromatic Pd(II) meso-tetrakis(pentafluorophenyl)porphyrin (Pd[TPFPP]) demonstrated this traditional tetrapyrrole does not display the excitation-wavelength dependent photophysics observed for the Pd(II) biladienes. These experiments confirm that the unusual photophysics we observe are unique to low-symmetry biladienes and do not apply to more well-studied porphyrinoids. The results of this work demonstrate that Pd(II) biladienes support a unique triplet photo-chemistry that may be exploited for development of new photochemical schemes and applications.
Flexible CO2 sensor architecture with selective nitrogen functionalities by one-step laser-induced conversion of versatile organic ink
Authors: Wang Huize , Otieno Ogolla Charles , Panchal Gyanendra , Hepp Marco , Delacroix Simon , Cruz Daniel , Kojda Danny , Ciston Jim , Ophus Colin , Knop-Gericke Axel , Habicht Klaus , Butz Benjamin , Strauss Volker
Published: May 2022

Nitrogen-doped carbons (NC) are a class of sustainable materials for selective CO2 adsorption. We introduce a versatile concept to fabricate flexible NC-based sensor architectures for room-temperature sensing of CO2 in a one-step laser conversion of primary coatings cast from abundant precursors. By the unidirectional energy impact in conjunction with depth-dependent attenuation of the laser beam, a layered sensor heterostructure with porous transducer and active sensor layer is formed. Comprehensive microscopic and spectroscopic cross-sectional analyses confirm the preservation of a high content of imidazolic nitrogen in the sensor. The performance was optimized in terms of material morphology, chemical composition, and surface chemistry to achieve a linear relative resistive response of up to ∆R/R0 = -14.3% (10% of CO2). Thermodynamic analysis yields ΔadsH values of -35.6 kJ·mol-1 and 34.1 kJ·mol 1 for H2O and CO2, respectively. The sensor is operable even in humid environments (e.g., ∆R/R0,RH=80% = 0.53%) and shows good performance upon strong mechanical deformation.
Tuning Ionic Screening to Accelerate Electrochemical CO2 Reduction in Ionic Liquid Electrolytes
Authors: Liu Beichen , Guo Wenxiao , Gebbie Matthew
Published: May 2022

Electric double layer formation often governs the rate and selectivity of CO2 electrochemical reduction. Ionic correlations critically define double layer properties that are essential to electrocatalytic performance, including capacitance and localization of potential gradients. However, the influence of ionic correlations on CO2 electro-reduction remains unexplored. Here, we use electrochemical conversion of CO2 to CO in ionic liquid-based electrolytes to investigate how the emergence of ionic correlations with increasing ion concentration influences reaction rates and selectivity. Remarkably, we find substantial acceleration of potential-dependent CO2 reduction rates and notable enhancement of faradaic efficiency to CO at intermediate concentrations of 0.9 M ionic liquid in acetonitrile, a concentration regime that has not been studied previously. We find that onset potentials for CO2 reduction remain relatively unchanged at -2.01 V vs. Ag/Ag+ from 0.025 M up to 1.1 M and increase to -2.04 V vs. Ag/Ag+ in the limit of neat ionic liquids. Hence, the acceleration of CO2 reduction we observe originates from the amplification of potential-dependent driving forces, as opposed to changes in onset potential. Importantly, our findings are general across co-catalytic and non-catalytic ions. We propose that concentrations of maximum reactivity correspond to conditions where electric double layers exhibit the strongest screening, which would localize electric fields to stabilize polar intermediates. Our study demonstrates that tuning bulk electrostatic screening lengths via modulation of ionic clustering provides a general approach to accelerating both inner sphere and outer sphere electrochemical reactions.
Thioester Mediated Biocatalytic Amide Bond Synthesis with In Situ Thiol Recycling
Authors: Schnepel Christian , Rodriguez-Perez Laura , Yu Yuqi , Angelastro Antonio , Heath Rachel S. , Lubberink Max , Falcioni Francesco , Mulholland Keith , Hayes Martin A. , Turner Nicholas J. , Flitsch Sabine L.
Published: May 2022

The conversion of carboxylic acids to thioesters is a key step in the biosynthesis of natural products, resulting in activation of the acyl groups for a broad range of subsequent biochemical reactions, such as acylations and alkylations. In particular, the thioesters of Coenzyme A (CoA-SH) play disproportionate roles in many metabolic pathways, from fatty acids, polyketides and peptides to epigenetic post-translational modifications, such as N-, O- and S-acylations of proteins. However, lack of access to a broad range of structurally diverse thioesters and the structural complexity of CoA-SH have limited the wider exploitation of thioesters in biochemistry, cell biology and biotechnology. Here we report an in-situ recycling system of thioesters from free carboxylic acids that aims to address these challenges. We show that the adenylation domain of the carboxylic acid reductase from Segniliparus rugosus (CARsr-A) can function as an efficient and robust acyl-S-CoA synthetase, accepting a wide range of carboxylic acids as substrates. In addition, CARsr-A was able to generate thioesters from structurally simpler thiols such as pantetheine. The resulting thioesters were shown to be substrates for acyltransferases leading to diverse amides, including more challenging targets such as pharmaceutically relevant aryl amides. Importantly, CoA-SH is regenerated in situ and can be used in sub-stoichiometric quantities. In a further application, the histone-derived peptide H4-20 was successfully acylated via thioester activation with a range of natural and unnatural ‘clickable’ carboxylic acids, by combination with the epigenetic ‘writer’ lysine acetyltransferase HATp300. Overall, this broad-spectrum biocatalyst for thioester synthesis, allowing in-situ CoA-SH recycling in combination with a range of thioester-dependent enzymes, provides a generic platform for thioester-dependent cell-free biosynthesis, with potential to open up applications beyond amide bond formation.
Density Layering During Gaseous Diffusion in Carbon Nanotubes: An Analytic Model
Authors: Barlow Douglas , Colson Fenner
Published: May 2022

Recently, molecular dynamics simulations have predicted that concentric layers of gaseous carbon dioxide particles will appear in carbon nanotubes. We show in this letter how this effect can be predicted analytically by considering the potential field generated by the pore wall. The layer potential expression thus derived can be used to reproduce the essential features of a particular MD study of gaseous carbon dioxide within a (40, 40) carbon nanotube and confirm, from an energetic point of view, that an outer gaseous layer will be stable. With a closed form expression for the layer potential known, we are able to derive formulas for quantities typically of interest in a Lennard-Jones analysis, such as minimum energy, equilibrium position and the location of zero potential.
Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26
Authors: Salerno-Kochan Anna , Horn Andreas , Ghosh Pritha , Nithin Chandran , Kościelniak Anna , Meindl Andreas , Strauss Daniela , Krutyhołowa Rościsław , Rossbach Oliver , Bujnicki Janusz M , Gaik Monika , Medenbach Jan , Glatt Sebastian
Published: May 2022

The TRIM-NHL protein Meiotic P26 (Mei-P26) acts as a regulator of cell fate in Drosophila. Its activity is critical for ovarian germline stem cell maintenance, differentiation of oocytes, and spermatogenesis. Mei-P26 functions as a post-transcriptional regulator of gene expression; however, the molecular details of how its NHL domain selectively recognizes and regulates its mRNA targets have remained elusive. Here, we present the crystal structure of the Mei-P26 NHL domain at 1.6 Å resolution and identify key amino acids that confer substrate specificity and distinguish Mei-P26 from closely related TRIM-NHL proteins. Furthermore, we identify mRNA targets of Mei-P26 in cultured Drosophila cells and show that Mei-P26 can act as either a repressor or activator of gene expression on different RNA targets. Our work reveals the molecular basis of RNA recognition by Mei-P26 and the fundamental functional differences between otherwise very similar TRIM-NHL proteins.
Preparation of a protein drink from fish protein hydrolysate obtained from
tilapia skin waste
Authors: Osiriphun S. , Wangtueai S. , Rachtanapun P. , Jirarattanarangsri W.
Published: May 2022

This study investigated the extraction of protein hydrolysate from tilapia skin waste and
its utilisation for the preparation of a protein drink. Tilapia skin was first prepared by
removing lipids using 95% ethanol. Protein hydrolysate was then extracted using 0.375%
papain at 40°C for 120 mins. The physicochemical properties of the protein hydrolysate
were analysed and were then used to prepare a protein drink. The analysis of shelf-life and
the prediction of shelf-life of products using the accelerated shelf-life testing method
(Q10) were carried out. The content of protein hydrolysate powder in tilapia skin was
29.68±1.32 (g/100 g). Sensory analysis results showed that the protein beverage received
an overall liking score of 7.13±1.27 from the sensory panel. Based on the Q10
calculations, the product shelf-life at the recommended temperature of 4°C with a safety
factor of 10% was 12 days. According to the Thai FDA for pasteurised beverage
regulation no. 195, the product complied with the Thai FDA standard guidelines. These
results suggested that the fish protein hydrolysate obtained from tilapia skin waste is a rich
resource of protein and is suitable for producing value-added fish skin protein drinks.
EFFECT OF CONSERVATION AND GRAZING ,ON THE STRUCTURE OF CENOPOPULATIONS IN THE COMMUNITY OF FESTUCA VALESIACA GAUDIN
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, RYBASHLYKOVA L.P.
Published: May 2022

Population analysis of plant communities makes it possible to predict the development and transformation of natural cenoses under anthropogenic effect, to solve problems aimed at optimizing the biogeocenotic cover. The Festuca valesiaca Gaudin community was studied in the southern arid zone of Russia. The experiment was carried out in the Baskunchak-Kharabalin plain in the specially protected area of the Bogdinsko-Baskunchaksky Nature Reserve, where the grazing regime is moderate. In the first case, cenopopulations of the normal type predominate, which is an indicator of their stability and the stability of the community as a whole. Grazing intensifies the processes of vegetative reproduction and seed invasion from other cenoses. This increases the number of individuals and species diversity. Under grazing conditions, the number of non-stable – invasive and invasively regressive cenopopulations increases. The Bassia prostrata (L.) Beck (Chenopodiaceae), Astragalus dolichophyllus Pall. (Fabaceae), Agropyron desertorum (Fisch ex Link) Schult. (Poaceae), Agropyron fragile (Roth) P. Candargy (Poaceae) cenopopulations fall first out of the community composition. The dominant Festuca valesiaca centropopulation plays a significant phytocoenotic role in steppe and semi-desert biocenoses and shows a high degree of stability without changing its parameters in the grazed area. It is concluded that moderate grazing, while increasing the species diversity of the community and the number of individuals, causes destabilisation and regression of a number of non-dominant cenopopopulations.
ORGANIZATION OF MANAGEMENT ACCOUNTING FOR THE CENTERS OF FINANCIAL RESPONSIBILITY OF AN ECONOMIC ENTITY IN THE CONTEXT OF APPLYING THE PROJECT MANAGEMENT SYSTEM
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, KOSTYUKOVA E.I. , BOBRYSHEV A.N. , FROLOV A.V. , AGAFONOVA N.P.
Published: May 2022

The unstable economic situation in both the Russian and global markets, combined with limited material, labor and other resources, leads to the need to create new management technologies. Standard methods and forms of organizing financial and economic activities are becoming less relevant due to low adaptability to changing conditions. The most flexible and strategic-oriented management system is project management, which is a management concept based on the labor, material and financial resources of an economic entity entrusted to an independent unit (project) to achieve specific objectives with specific requirements for time, quality, money and material resources. Project management is widely used in the public sector as it enables the achievement of the set goals within the set timeframe and cost limits. The prevalence of project management in business sector has been growing in recent years, but it cannot fully function without prompt and objective information support. The traditional accounting system is not always able to fully meet the information needs of users due to significant differences in the implementation of process and project activities. The introduction of an autonomous management accounting system that accumulates relevant information on economic, business and other processes for effective decision-making by management personnel can help to solve this
Toeplitz Matrix and Nyström Method for Solving Linear Fractional Integro-differential Equation
Authors: Raad Sameeha , AlQurashi Khawlah
Published: May 2022

In this paper, the Volterra-Fredholm integral equation is derived from a linear integro-differential equation with a fractional order 0 < α < 1 using Riemann–Liouville fractional integral. The existence and uniqueness of the solution are proved using the Picard method. Popular numerical methods; the Toeplitz matrix, and the product Nystr ̈om are used in the solution. These methods will prove their effective in solving this type of equation. Two examples are solved using the mentioned methods and the estimation error is calculated. Finally, a comparison between the numerical results is made.
Refuerzo académico para el desarrollo de habilidades comunicativas en inglés por medio de actividades permanentes
Authors: Nieto Chávez Karla Ivette , Dueck Klassen Perla Suggeith , Salinas Cervantes Lynda
Published: May 2022

El presente trabajo se basa en la relación entre los refuerzos académicos utilizados por los maestros de inglés de una Escuela Normal al norte de México y la perspectiva de los alumnos con respecto a su utilidad en el desarrollo de habilidades comunicativas en el inglés como una segunda lengua. Dichos refuerzos constan de actividades semanales permanentes con una variedad de temas que requieren de la combinación de habilidades para su elaboración. En esta investigación se rescatan conceptos relacionados con refuerzo académico y adquisición de una segunda lengua. Además, se utiliza un enfoque cualitativo con metodología descriptiva y se recaba información por medio de la observación y un cuestionario administrado, de tal forma que permite documentar la estrategia aplicada por los docentes de inglés y su efecto en el aprendizaje de los alumnos. Respecto a los resultados, destaca que los alumnos encuentran este tipo de actividades útiles, motivadoras y variadas, les llaman la atención y les permiten progresar sin tener que dedicarle mucho tiempo a su realización. En la conclusión se identifica que se puede dar continuidad a las actividades, al mismo tiempo que se aumente el nivel de dificultad para cumplir con las necesidades de los alumnos, pues son ellos mismos quienes perciben mejoras en sus habilidades comunicativas del segundo idioma.
The usefulness of the “Teaching Knowledge Test” and its preparation course: A case study of test candidates in Tamaulipas
Authors: Saucedo Ibarra Cyntia , González Quintero Elsa Fernanda
Published: May 2022

ELT in Mexico has gained crucial importance in recent years. Since 2009, the Mexican Ministry of Education has implemented English as a Foreign Language in the basic education curriculum. Universities around the country require their students´ a specific language proficiency to obtain their under and postgraduate degrees (UAT, 2006). Therefore, English teaching certifications become a matter of importance not just at a national level but at state levels. According to Coe & Delaney (2008), a certification helps an individual stand out in the crowded marketplace. It also signals to employers that a job candidate has the required skills to perform a specific job. Therefore, understanding EFL teachers´ experiences during the process of certification completion becomes vital. This multiple case study had the purpose of exploring the perspectives of three Mexican test candidates of the usefulness of the “Teaching Knowledge Test” (TKT) certification and its preparation course. Three interviews conducted at different stages of the study suggested that time was their main constraint and the practice of their English language skills was the main gain while preparing to take the TKT. This article will provide more insights on the study conducted, results obtained and the implications for the Mexican ELT community.
Encourager la réflexion transculturelle en cours de français à partir d’une œuvre emblématique d’un peintre acadien contemporain
Authors: Navarro Bajar Rebeca Isabel
Published: May 2022

Prenant comme point de départ le remake contemporain d’une œuvre phare pour l’histoire des Acadiens (les premiers colons francophones qui se sont installés sur notre continent) cet article présente une démarche pédagogique pour la classe de français qui vise à initier les apprenants à la connaissance de l’histoire du peuple acadien tout en les impliquant dans une mouvance transculturelle. Dans un premier temps une sensibilisation à la notion de transculturalité en tant qu’élément-clé pour appréhender la culture globale contemporaine sera entamée. Dans un deuxième temps, de nature éminemment pratique, l’enseignant de français trouvera une proposition didactique concrète pour faire découvrir à ses apprenants, à partir d’une œuvre d’art contemporaine du peintre acadien Mario Doucette, un événement historique majeur de l’histoire acadienne – à savoir, « Le Grand Dérangement » –. Le travail proposé autour du tableau lui permettra d’engager, auprès de ses apprenants, une réflexion de nature transculturelle, sans négliger pour autant l’occasion de leur faire pratiquer des aspects linguistiques spécifiques de la langue cible. Finalement, un retour sur la notion de transculturalité sera abordé, en vue de soulever son importance dans le cadre de la didactique des langues-cultures étrangères (DLE) et de mettre l’accent sur son potentiel porteur d’espoir.
Editorial
Authors: Souza Reis Cristiane , Bon Vecchio Fabrizio
Published: May 2022

Editorial
Behavior and Burdens
Authors: Herd Pamela , Moynihan Donald
Published: May 2022

The topic of administrative burden is relatively novel, but reflects people’s most common experiences of government: confusion about what is expected of them (learning costs), onerous processes (compliance costs), and associated emotions such as frustration (psychological cost). This symposium applies a behavioral perspective to the topic. We learn, for example, of the role of race and social constructions in people’s beliefs about burdens and their role in social programs. We are given evidence of how burdens restrict access to important public services. Perhaps most usefully, the authors engage with different interventions to find ways to reduce burdens. This ranges from changes in the physical space, to process redesign, to informational nudges. The resulting work provides a broad range of applied empirical insight that shines a light on a pressing area of study.
Evaluation of a Lignin Bio-alkyd Resin for the Selective Determination of Molybdenum in Biological, Pharmaceutical, Fertilizer and Water Samples
Authors: Moawed Elhossein , Ragab Sara , El-Shobaky Amira , El Hagrasy Maha
Published: May 2022

A lignin-based bio-alkyd resin (LA-Resin) was synthesized by the polycondensation reaction of lignin with a mixture of palmitic acid and glycerol. The LA-Resin was characterized using many techniques, including scanning electron microscope, FTIR, X-ray diffraction and thermal analysis. LA-Resin was proven to have graphitized structures with enhanced surface functional groups, showing a slightly basic character (pHZCP = 7.8). It has a relatively better cation exchange capacity (0.70 mmol g-1) in addition to the ability for physical adsorption. The performance of LA-Resin was assessed for the uptake of molybdenum (Mo), followed by spectrophotometric determination, applying both batch and column techniques. Elevated sorption percentages of Mo were observed in acidic medium H2SO4 (1.5 mol L-1) in the presence of ascorbic acid (0.050 mol L-1) and NH4SCN (0.10 mol L-1). The method was successfully applied to the separation and determination of Mo in mice liver, pharmaceuticals, water and fertilizer samples. Validation showed good recovery (96.6-99.6%), sensitivity (LOD, 0.9-4.0 μg L-1), repeatability (RSD% ≤1.5%) and linearity (R2 = 0.984), demonstrating a good quantitative performance of the method. Mo in all investigated samples regardless of different matrices were well-separated and detected, indicating that the method is sensitive enough to detect low concentrations of Mo even in small samples such as mice liver.
Cermet plasma coatings with TiC and TiCrC carbides
Authors:   Baikov Institute of metallurgy and materials science of the Russian academy of sciences, Kalita V.I. , Radyuk A. A. ,   Baikov Institute of metallurgy and materials science of the Russian academy of sciences, Komlev D.I. ,   Baikov Institute of metallurgy and materials science of the Russian academy of sciences, Shamrai V. F. ,   Baikov Institute of metallurgy and materials science of the Russian academy of sciences, Mikhailova A. B. ,   Baikov Institute of metallurgy and materials science of the Russian academy of sciences, Alymov M. I. ,   Baikov Institute of metallurgy and materials science of the Russian academy of sciences, Alpatov A. V. ,   Baikov Institute of metallurgy and materials science of the Russian academy of sciences, Titov D. D. ,   Baikov Institute of Metallurgy and Materials Science RAS
Published: May 2022

Four plasma cermet coatings with similar compositions based on TiC carbide and NiCrMo matrices with additional Cr3C2, WC carbides, and carbon were studied. The average oxygen content for four cermets increases from 0.51 % for powders to 0.86 % for coatings with a minimum plasma power and does not increase with its increase. The maximum average nitrogen content in the coatings, 0.34 %, is determined by the nitrogen content in the plasma. When spraying coatings, the loss of carbon, relative to the initial powder composition, is 2.79 – 3.76 %, less than in the manufacture of powders for spraying 4.3 – 6.6 %. Carbides Cr3C2, WC, matrix elements and the content of additional carbon determine the formation of the annular zone around TiC carbide, increase the total carbide content in the coating from 60 to 74 – 83% and the microhardness of the coating is 18 GPa with an indenter load of 200 gf.