bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimized type-2 fuzzy controller based on IoMT for stabilizing the glucose level in type-1 diabetic patients
Authors: Sayed Amged , Zalam Belal A. , Elhoushy Mohanad , Nabil Essam
Published: September 2023

Due to advancements in existing Internet of Medical Things (IoMT) systems and devices, the blood glucose level (BGL) for type-1 diabetic patients (T1DPs) is effectively and continually monitored and controlled by Artificial Pancreas. Because the regulation of BGL is a very complex process, many efforts have been conducted to design a powerful and effective controller for the exogenous insulin infusion system. The main objective of this study is to propose an optimized interval type-2 fuzzy (IT2F) based controller of artificial pancreas for regulation BGL of T1DP based on IoMT. The proposed controller should avoid the risk of hyperglycemia and hypoglycemia situations that T1DP faces during the infusion of exogenous insulin. The main contribution of this work is using meta-heuristic method called grey wolf optimizer (GWO) to tune the footprint of uncertainty for IT2F’s membership functions to inject the proper dose of insulin under different conditions. The nonlinear extended Bergman minimal model (EBMM) with uncertainty is used to represent the blood glucose regulation and represent the dynamics of meal disturbance in T1DP. The effectiveness and the performance of the proposed controller are investigated using MATLAB/Simulink platform. Simulation results show that the proposed controller can avoid both severe hypoglycemia and hyperglycemia for nominal parameters of the model, in addition to model under the presence of both parametric uncertainty and uncertain meal disturbance.
Developmental validation of Applied Biosystems YFiler Platinum Casework PCR Amplification Kit
Authors: Lee Sumin , McAnany Peterjon K. , Chang Chien Wei , Norona Wilma , Short Marc L. , Mulero Julio J. , Zhong Chang
Published: September 2023

The YFiler Platinum Casework PCR Amplification Kit is a 6-dye multiplex assay that simultaneously amplifies a set of 38 male-specific, Y-chromosome Short Tandem Repeat (YSTR) markers (DYS576, DYS389I, DYS635, DYS389II, DYS627, DYS549, DYS593, DYS645, DYS460, DYS458, DYS19, YGATAH4, DYS448, DYS391, DYS557, DYS522, DYS456, DYS390, DYS438, DYS392, DYS518, DYS444, DYS533, DYS570, DYS437, DYS385, DYS449, DYS643, DYS596, DYS393, DYS439, DYS481, DYF387S1, DYS527, DYS447), three insertion/deletion polymorphic markers (Yindels: rs771783753, rs759551978, rs199815934), and an internal quality control (IQC) system. When compared to the YFiler Platinum PCR Amplification kit for database samples, YFiler Platinum Casework kit was developed to include an improved Primer Mix incorporating a brighter TED dye, an updated internal quality control system, better resolution of large DNA fragments in Applied Biosystems POP-4 Polymer, and reduced female DNA cross-reactivity. Here, we report the results of the developmental validation study which followed the Scientific Working Group on DNA Analysis Methods (SWGDAM) guidelines and includes data for PCR-based studies, sensitivity, species specificity, stability, precision, reproducibility and repeatability, population concordance, stutter, DNA mixtures, and performance on mock casework samples. The results validate the multiplex design as well as demonstrate the kit’s robustness, reliability, and suitability as an assay for human identification with casework DNA samples.
The effect of caponization on bone homeostasis of crossbred roosters. I. Analysis of tibia bone mineralization, densitometric, osteometric, geometric and biomechanical properties
Authors: Wojciechowska-Puchałka J. , Calik J. , Krawczyk J. , Obrzut J. , Tomaszewska E. , Muszyński S. , Wojtysiak D.
Published: September 2023

The presented study focuses on assessing the effect of caponization on the densitometric, osteometric, geometric and biomechanical parameters of tibial bones in crossbred chickens. The study was carried out on 96 hybrids between Yellowleg Partridge hens (Ż-33) and Rhode Island Red cockerels (R-11) aged 16 weeks, 20 weeks and 24 weeks. Birds were randomly assigned to 2 groups-the control group (n = 48; which consisted of intact roosters) and the experimental group (n = 48, which consisted of individuals subjected to caponization at the age of 8 weeks). The caponization had no effect on the densitometric, osteometric and geometric parameters (except the horizontal internal diameter of 16-week-old individuals) of tibia bone, as well as the content of calcium (Ca), phosphorus (P) and the Ca/P ratio in the bone mineral fraction in all analyzed age groups of animals. However, it contributes to a lower percentage of ash in the bones of capons at 20 and 24 weeks of age compared to cockerels. On the contrary, some mechanical and material parameters show the negative effect of caponization. Ultimate load and bending moment decreased in capons in all of the analyzed age groups of animals and yield load, stiffness and ultimate stress also decreased but only in the group of 20-week-old and 24-week-old individuals. This can contribute to the weakening of the capon bones, and in the perspective of prolonged maintenance to their deformation and even fracture.
Research on industrial carbon emission prediction and resistance analysis based on CEI-EGM-RM method: a case study of Bengbu
Authors: Dai Dawei , Zhou Biao , Zhao Shuhang , Li Kexin , Liu Yuewen
Published: September 2023

This paper focuses on the development trend of industrial carbon emissions in Bengbu city, Anhui Province in the next ten years, and how to help the industry reach the carbon peak as soon as possible. The research process and conclusions are as follows: (1) Through literature review and carbon emission index method, five main factors affecting industrial carbon emission are identified. (2) The resistance model is used to analyze the main resistance factors of industrial carbon emission reduction in Bengbu city. (3) Based on the existing data of Bengbu city from 2011 to 2020, the grey prediction EGM (1,1) model is used to predict the industrial carbon emissions of Bengbu city from 2021 to 2030. The results show that among the five factors, the urbanization rate has the most significant impact on industrial carbon emissions, while energy intensity has the least impact. Bengbu’s industrial carbon emissions will continue to increase in the next decade, but the growth rate will be flat. Based on the findings of the analysis, specific recommendations on urbanization development, energy structure, and industrial structure of Bengbu city are put forward.
Comparison of cardiometabolic risk factors between obese and non-obese patients with nonalcoholic fatty liver disease
Authors: Yari Zahra , Fotros Danial , Hekmatdoost Azita
Published: September 2023

Nonalcoholic fatty liver disease (NAFLD) is closely associated with cardiometabolic abnormalities. This association could be partly influenced by weight, but not entirely. This study aimed to compare the cardiometabolic risk factors between obese and non-obese NAFLD patients, and explored the relationship between adiposity and severity of fatty liver. This cross-sectional study included 452 patients with Fibroscan-proven NAFLD. Anthropometric measurements, metabolic components and hepatic histological features were evaluated. The risk of metabolic syndrome in each body mass index (BMI) category was analyzed using logistic regression. The prevalence of metabolic syndrome was 10.2%, 27.7%, and 62.1% in normal-weight, overweight and obese participants. Regression analysis showed that the risk of metabolic syndrome in overweight and obese NAFLD patients was 3.74 and 4.85 times higher than in patients with normal weight, respectively. Waist circumference (β = 0.770, P < 0.001) and serum concentration of fasting blood glucose (β = 0.193, P = 0.002) and triglyceride (β = 0.432, P < 0.001) were the determinants of metabolic syndrome occurrence in NAFLD patients. Metabolic abnormalities were similar in obese and non-obese NAFLD patients, although, the increase in BMI was associated with an increased risk of metabolic syndrome in patients.
Enzyme cocktail with hyperactive lipase through solid-state fermentation by the novel strain Penicillium sp. Y-21
Authors: Cai Yang , Yang Guanghua
Published: September 2023

Lipase is a kind of industrial enzyme preparation with various catalytic abilities and is widely used in food, energy, medicine and other fields. To increase lipase and enzyme cocktail activity through solid-state fermentation, the novel strain Penicillium sp. Y-21 was obtained through ethyl methanesulfonate (EMS) mutation from the novel strain Y, which was isolated from soils. Solid-state fermentation by strain Y-21 using agricultural byproducts was carried out in tray bioreactors. The optimum culture composition for enzyme cocktail fermentation was soybean meal 20 g, 3% (w/w) glucose, 1% (w/w) peptone, 5% (w/w) lard, 0.04% (w/w) CaCl2, 0.04% (w/w) FeCl3, 28 °C for 72 h. The enzyme cocktail produced by strain Y-21 is a kind of multienzyme complex, containing xylanase, glucanase, acidic protease, pectinase, cellulase and lipase, and their enzymatic activities (unit: U g−1) were 8000, 6000, 8000, 2000, 3000 and 120, respectively. During the fermentation process, the lipase coding genes pel, pha, and p12 were also studied and amplified from the RNA of Penicillium sp. Y-21 by RT-PCR. The results showed that the pel gene played an important role in enzyme production. Afterwards, an enzyme cocktail can be added to chicken feed as an additive, which improves animal growth and feed efficiency.
Topological capture of mRNA for silencing gene expression
Authors: Lyu Fangjie , Tomita Takashi , Abe Naoko , Hiraoka Haruka , Hashiya Fumitaka , Nakashima Yuko , Kajihara Shiryu , Tomoike Fumiaki , Shu Zhaoma , Onizuka Kazumitsu , Kimura Yasuaki , Abe Hiroshi
Published: September 2023

Topological capturing of mRNA by bifurcated reactive oligodeoxynucleotides resulted in higher gene silencing effect than the corresponding canonical antisense strand.
An electrochemically fabricated ZIF-67/[HOEMIM]BF4 coating for the solid-phase microextraction and detection of polycyclic aromatic hydrocarbons
Authors: Lin Jingwen , Gao Xuening , Gong Linbo , Zhang Xiaoqing , Li Tianning , Zhao Faqiong , Zeng Baizhao
Published: September 2023

A novel coating named ZIF-67/[HOEMIM]BF4 was fabricated through in situ potentiostatic electrodeposition. This developed method provided a simple process with reduced processing time, enhanced extraction performance and improved practicality.
Super-resolution Raman imaging towards visualisation of nanoplastics
Authors: Fang Cheng , Luo Yunlong , Naidu Ravi
Published: September 2023

Through algorithmic enhancements, general confocal microscopy can effectively break through the diffraction limit of excitation light, enabling super-resolution Raman imaging for precise nanoplastic detection and visualisation.
Development and validation of an improved QuEChERS method for the extraction of semi-volatile organic compounds (SVOCs) from complex soils
Authors: Lou Hongbo , Wang Fujia , Zhao Hangchen , Wang Sufang , Xiao Xinxin , Yang Yanmei , Wang Xiaowei
Published: September 2023

Developed is a fast, low-cost, and efficient pre-treatment method that can extract semi-volatile organic compounds from coking polluted soil, save a lot of time and reduce the amount of organic solvents used.
Quantum shells versus quantum dots: suppressing Auger recombination in colloidal semiconductors
Authors: Beavon Jacob , Huang Jiamin , Harankahage Dulanjan , Montemurri Michael , Cassidy James , Zamkov Mikhail
Published: September 2023

Semiconductor quantum shells – an emerging nanomaterial class for optical gain media, photovoltaic, and high-energy radiation detection applications.
Structural modulation of membrane-intercalating conjugated oligoelectrolytes decouples outer membrane permeabilizing and antimicrobial activities
Authors: Moreland Alex S. , Limwongyut Jakkarin , Holton Samuel J. , Bazan Guillermo C.
Published: September 2023

A homologous series of membrane-intercalating conjugated oligoelectrolytes reveals that their antimicrobial and outer membrane permeabilizing activities are governed by independent structural parameters.
Promoting electrochemical nitrogen fixation by nanoporous AuCu alloys
Authors: Yang Yijie , Zhao Shulin , Pang Yue , Tang Guorui , Song Yu , Jiang Muyang , Li Cheng-Peng
Published: September 2023

This work presents a unique electrocatalyst of nanoporous AuCu electrocatalyst, achieving superior eNRR enhancement with high faradaic efficiency of 45.7%.
Two and three-dimensional halogen-bonded frameworks: self-assembly influenced by crystallization solvents
Authors: Liu Chuan-Zhi , Wang Jing-Jing , Yang Bo , Li Zhong-Yi , Yan Meng , Liu Xin-Ming , Hu Zhi-Yuan , Liu Lan-Tao , Li Zhan-Ting
Published: September 2023

Two types of 2D and 3D XBOFs were selectively constructed from identical building blocks by changing the crystallization solvent.
Amazing enhancement of OER performances: creating a well-designed functional Ni and N-doped carbon layer as a support material for fabricating a NiFe-LDH electrocatalyst
Authors: Wei Yu , Han Zhenze , Liu Taolue , Ding Xin , Gao Yan
Published: September 2023

By introducing the NNC support layer, the loading of the catalyst and the transfer of electrons are significantly improved, and therefore the OER performance of the electrode is substantially enhanced.
A redox-neutral weak carbonyl chelation assisted C4–H allylation of indoles with vinylcyclopropanes
Authors: Basak Shubhajit , Paul Tripti , Punniyamurthy Tharmalingam
Published: September 2023

Removable chelating group-assisted Ru-catalyzed distal C4–H allylation of indoles has been accomplished using vinylcyclopropanes as the allylating agent with broad substrate scope.
Novel Fe2O3 microspheres composed of triangular star-shaped nanorods as an electrode for supercapacitors
Authors: Song Zhiting , Hu Hongming , Shu Kai , Liu Tao , Tang Xiao , Zhou Xianju , Li Yanhong , Zhang Yunhuai
Published: September 2023

Fe2O3 with a novel structure was synthesized and it exhibited remarkable cycling stability as an electrode for supercapacitors.
Chiroptical regulation of macrocyclic arenes with flipping-induced inversion of planar chirality
Authors: Zhao Ting , Wu Wanhua , Yang Cheng
Published: September 2023

Studies on various macrocyclic arenes have received increasing attention due to their straightforward syntheses, convenient derivatization, and unique complexation properties.
16-Vertex oblato–hypho-titanaborane [(Cp*Ti)2B14H18]
Authors: Kar Sourav , Bairagi Subhash , Halet Jean-François , Ghosh Sundargopal
Published: September 2023

16-Vertex hypho-clusters [(Cp*Ti)2B14H17R] (1: R = H; 2: R = Me) have been isolated and structurally characterized. The isolation of these hypho-clusters offers possibilities for the synthesis of clusters beyond 16-vertices.
C–H hydrogen bond and halogen bond directed self-assembly of ethereal podands and C–X⋯F−/HF2− halogen bonding in solution
Authors: Dutta Dipjyoti , Gogoi Anamika , Dutta Rupjyoti , Harmalkar Sarvesh S. , Lama Prem , Dey Sandeep Kumar
Published: September 2023

Crystallization of halophenyl-functionalized ethereal podands is largely facilitated by C–H hydrogen bonds and halogen bonds of similar strength, and anion binding in the solution state is exclusively governed by halogen bonding.
Multiple strategies of improving photocatalytic water splitting efficiency in 2D arsenic sesquichalcogenides
Authors: Li Xiaoteng , Yang Chuanlu , Liu Yuliang , Han Endao , Zhao Wenkai , Jiang Xinxin , Zou Dongqing , Xu Yuqing
Published: September 2023

As2STe2 and As2SeTe2 monolayers can act as IR photocatalysts for overall water splitting with STH efficiencies of 36.19% and 29.36%, respectively.
Smart organic materials based on macrocycle hosts
Authors: Lou Xin-Yue , Zhang Siyuan , Wang Yan , Yang Ying-Wei
Published: September 2023

A succinct and illustrative summary of the recent progress of supramolecular smart organic materials based on macrocycle hosts is provided spanning the aspects of design principles, functioning mechanisms, and relative applications.
Reply to the ‘Comment on “Strong Be–Be bonds in double-aromatic bridged Be2(μ-SO) molecules”’ by A. Guha, Dalton Transactions, 2023, 52, D3DT00774J
Authors: Rezaie F. , Noorizadeh S.
Published: September 2023

Although a bridged Be2(μ-SO) structure is less stable than a Be2SO molecule, the Be–Be bond and the Be–Be distance are predicted for these structures, respectively.
Design of carbazole-based platinum complexes with steric hindrance for efficient organic light-emitting diodes
Authors: Luo Xu-Feng , Ning Sheng , He Hang , Tang Hao , Shen Liang-Jun , Shen Yi-Rui , Han Hua-Bo , Xiao Xunwen , Zheng You-Xuan
Published: September 2023

The construction of platinum complexes with high steric hindrance is expected to suppress triplet–triplet annihilation and π–π stacking to achieve high-performance organic light-emitting diodes (OLEDs) with low efficiency roll-off.
G-quadruplex DNA selective targeting for anticancer therapy: a computational study of a novel PtII monofunctional complex activated by adaptive binding
Authors: Belletto Daniele , Ponte Fortuna , Sanna Nico , Scoditti Stefano , Sicilia Emilia
Published: September 2023

A novel monofunctional PtII complex, whose selectivity for a G-quadruplex is triggered by adaptive binding, has been computationally investigated. DFT and molecular dynamics calculations were performed in order to shed light on the mechanism of action.
Distal renal tubular system-on-a-chip for studying the pathogenesis of influenza A virus-induced kidney injury
Authors: Huangfu Yueyue , Wang Ji , Feng Jiao , Zhang Zhi-Ling
Published: September 2023

The intelligence of viruses is unveiled in this study utilizing a distal renal tubular system-on-a-chip, demonstrating their ability to rapidly spread through tissues.
Editor’s Choice: Chiral Functional Materials
Authors: Cui Yong
Published: September 2023

Materials Horizons Editorial Board Member Professor Yong Cui (Shanghai Jiao Tong University, China) introduces this Editor’s Choice collection on Chiral Functional Materials.
A visible light-driven NaTiO3/g-C3N4 heterojunction photocatalyst for ultra-fast organic dye degradation
Authors: V. K. Amritha , Badhulika Sushmee
Published: September 2023

A NaTiO3/g-C3N4 heterojunction photocatalyst is reported for the first time, exhibiting fast response (15 min) in degrading organic dyes in the presence of sunlight.
Enhancing the efficiency of benzylamine oxidative coupling over N-doped porous carbon-supported CeO2 and ZrO2 nanoparticles
Authors: Chen Jie , Jian Mingyuan , Zhuang Lei , Lin Wenting , Fu Yanghe , Chen De-Li , Zhu Weidong , Chen Guihua , Zhang Fumin
Published: September 2023

The developed CeZr-NC-T exhibited excellent catalytic performance in the oxidative coupling of benzylamines with molecular oxygen under mild conditions.
Recent advances on sustainable removal of emerging contaminants from water by bio-based adsorbents
Authors: Bobde Prakash V. , Sharma Amit K. , Kumar Ranjit , Pandey Jitendra K. , Wadhwa Shikha
Published: September 2023

Review of classification, application, the advantages and disadvantages of bio-based adsorbents, possible mechanisms of CECs adsorption, regeneration & stability of bio-based adsorbents. Key recommendations on CEC removal using bio-based adsorbents.
A reconfigurable ultra-broadband transparent absorber combined with ITO and structural water
Authors: Wang Yang , Yang Helin , Wu Jiong , Yang Yuejie , Jin Jing , Geng Xuxing , Huang Xiaojun
Published: September 2023

The design of a reconfigurable absorber using an all-transparent dielectric improves the overall optical transparency. By controlling its two states, with and without water, switching between dual-band and ultra-wideband absorption can be realized.
Strategic design of gold nanocatalysts for effective photocatalytic organic transformation
Authors: Kim Jongchan , Lee Jeonghyeon , Choi Hyunwoo , Ha Juhee , Cheon Minsoo , Seo Youngran , Kim Youngsoo , Yoo Dongwon
Published: September 2023

The design strategy of free-standing Au nanocatalysts was explored by correlating their physicochemical characteristics with photocatalytic performance.
Electrochemical direct C–H mono and bis-chalcogenation of indolizine frameworks under oxidant-free conditions
Authors: Chouhan Amreen , Ucheniya Kusum , Yadav Lalit , Jat Pooja Kumari , Gurjar Asha , Badsara Satpal Singh
Published: September 2023

A sustainable electrochemical approach for site-selective C–H mono and bis-chalcogenation (sulfenylation or selenylation) of indolizine frameworks is described.
Polyethylene and poly(ethylene-co-vinyl acetate) star polymers by iodine transfer polymerization
Authors: Baffie Florian , Boyron Olivier , Lansalot Muriel , Monteil Vincent , D'Agosto Franck
Published: September 2023

Iodine transfer (co)polymerization (ITP) was employed to form polyethylene (PE) and poly(ethylene-co-vinyl acetate) (EVA) stars.
Retraction: Structural characterization and anticancer potency of centipede oligopeptides in human chondrosarcoma cancer: inducing apoptosis
Authors: Ren Yuebing , Song Haibo , Wu Yuanpeng , Ma Xiaochun , Yu Xuezhong , Liu Jia , Sun Jianhui , Zhang Zhicheng
Published: September 2023

Retraction of ‘Structural characterization and anticancer potency of centipede oligopeptides in human chondrosarcoma cancer: inducing apoptosis’ by Yuebing Ren et al., RSC Adv., 2020, 10, 29780–29788, https://doi.org/10.1039/D0RA04811A.
Conversion of low-density polyethylene plastic waste into valuable fuels using fly ash as a catalyst
Authors: Khan Asif , Iqbal Naseem , Noor Tayyaba , Zaman Neelam , Khan Shoaib Raza
Published: September 2023

Waste low-density polyethylene (LDPE) plastic was pyrolyzed using a batch reactor fuel oil fly ash catalyst into valuable fuels using fly ash as a catalyst.
Hydrogenation of biodiesel catalysed by pyrazolyl nickel(ii) and palladium(ii) complexes
Authors: Olaoye Oluwasegun Emmanuel , Oyetunji Olayinka , Makhubela Banothile C. E. , Kumar Gopendra , Darkwa James
Published: September 2023

The pyrazolyl complexes have been explored as catalysts for applications that show how potential fuels can be made sustainably.
Commentary on: The actin bundling activity of ITPKA mainly accounts for its migration-promoting effect in lung cancer cells
Authors: Zhang Xin , He Jiadi , Ren Dong
Published: September 2023

1,4,5-triphosphate 3-kinase A (ITPKA) was first described and characterized by Irvine et al. in 1986 and cloned by Takazawa et al. in 1990. It is one of the components of the Ca2+ and calmodulin signaling pathway and a substrate for cAMP-dependent kinase (PKA) and protein kinase C (PKC), and is mainly involved in the regulation of intracellular inositol polyphosphate signaling molecules. Through a series of studies, Sabine’s team has found that ITPKA expression was up-regulated in a variety of cancer cells, and silencing ITPKA inhibited while overexpressing ITPKA promoted cancer cell migration in vitro and metastasis in vivo. The latest research from Sabine’s team has demonstrated that in H1299 lung cancer cells, the mechanism by which ITPKA promoted migration and invasion was predominantly depending on the ability of binding to F-actin, which will induce cancer cells to form a tight flexible actin networks. Small molecule compounds targeting the IP3 kinase activity of ITPKA protein may only inhibit the migration and invasion of cancer cells caused by the enhanced ITPKA kinase activity under ATP stimulation, but not the cytoskeletal remodeling caused by the binding of ITPKA protein to F-actin and the driven migration and invasion of cancer cells. Therefore, targeted therapeutic strategy focusing on blocking the binding of ITPKA to F-actin is indispensable when designing the inhibitors targeting ITPKA protein.
Protonated hydrogen cyanide as a tracer of pristine molecular gas
Authors: Gong Y. , Du F. J. , Henkel C. , Jacob A. M. , Belloche A. , Wang J. Z. , Menten K. M. , Yang W. , Quan D. H. , Bop C. T. , Ortiz-León G. N. , Tang X. D. , Rugel M. R. , Liu S.
Published: September 2023

Context. Protonated hydrogen cyanide, HCNH+, plays a fundamental role in astrochemistry because it is an intermediary in gas-phase ion-neutral reactions within cold molecular clouds. However, the impact of the environment on the chemistry of HCNH+ remains poorly understood.

Aims. We aim to study HCNH+, HCN, and HNC, as well as two other chemically related ions, HCO+ and N2H+, in different star formation regions in order to investigate how the environment influences the chemistry of HCNH+.

Methods. With the IRAM 30 m and APEX 12 m telescopes, we carried out HCNH+, H13CN, HN13C, H13CO+, and N2H+ imaging observations toward two dark clouds, the Serpens filament and Serpens South, both of which harbor sites of star formation that include protostellar objects and regions that are quiescent.

Results. We report the first robust distribution of HCNH+ in the Serpens filament and in Serpens South. Our data suggest that HCNH+ is abundant in cold and quiescent regions but is deficient in active star-forming regions. The observed HCNH+ fractional abundances relative to H2 range from 3.1 × 10−11 in protostellar cores to 5.9 × 10−10 in prestellar cores, and the HCNH+ abundance generally decreases with increasing H2 column density, which suggests that HCNH+ coevolves with cloud cores. Our observations and modeling results suggest that the abundance of HCNH+ in cold molecular clouds is strongly dependent on the H2 number density. The decrease in the abundance of HCNH+ is caused by the fact that its main precursors (e.g., HCN and HNC) undergo freeze-out as the number density of H2 increases. However, current chemical models cannot explain other observed trends, such as the fact that the abundance of HCNH+ shows an anticorrelation with that of HCN and HNC but a positive correlation with that of N2H+ in the southern part of Serpens South’s northern clump. This indicates that additional chemical pathways have to be invoked for the formation of HCNH+ via molecules such as N2 in regions in which HCN and HNC freeze out.

Conclusions. Both the fact that HCNH+ is most abundant in molecular cores prior to gravitational collapse and the fact that low-J HCNH+ transitions have very low H2 critical densities make this molecular ion an excellent probe of pristine molecular gas.
Effective stimulator for rice yield improvement
Authors: ZakirovIsaline S. Kh. , MukhidovaI Z. Sh. , Otamirzaev N. G.
Published: September 2023

As a result of the conducted research, an effective stimulant was found - a natural sesqui terpenoid, which, with a single presowing treatment, allows increasing the yield of rice by 5 c / ha more than the drugs used.
Breeding of entomopathogenic fungi in different substrates
Authors: Ablazova Mokhichekhra , Zuparov Mirakbar , Zuparova Dilobar
Published: September 2023

The issue of entomopathogenic fungi’s prodigious rate of reproduction plagues both academic research and clinical practice. Several production technologies and preparations based on them are currently available. These medications appear to be liquid, powdery, dry, and grainy. The selection of nutritional medium and substrates, as well as the identification of ideal breeding conditions, are crucial steps in the manufacturing of pesticide formulations. Making preparations based on fungus is successful when solid nutritional substrates are used. Because in solid nutritional medium, fungus develop more spores. This article presents the results of experiments on the selection of nutrient substrates EMV-71 for the cultivation of strains of P. varioti EMR-57 and B. bassiana, which have been found to be virulent against spider mites and aphids, for use against sucking pests of vegetable crops in greenhouses. Barley grain has been found to be the most effective food substrate for the cultivation of entomopathogenic fungal strains and obtaining large numbers of spores from them.
Effectiveness of breeding larvae of the black soldier fly (Hermetia Illucens Linnaeus, 1758) on bran substrate
Authors: Allabergenova Dinara , Kultoev Gulom , Mamatkulov Abdurahim , Aliyarov Panji , Mullabaev Nodirbek
Published: September 2023

The black soldier fly Hermetia illucens breeding began in the 90s of the 20 century and was considered as an ecological solution for turning agricultural waste into a protein-rich organic compound. Two problems can be solved by breeding flies: firstly, agricultural and food waste is disposed of in an ecological way, and secondly, valuable protein raw materials are obtained. Through this technology, the shortage of important nutritional components for the aquaculture and poultry sector will be eliminated. In addition, this component is very close to the content of fish meal, which is deficient in composition, and can be used instead of fish meal within the specified amount. The advantages of this component are that the product reaches mass within 10 days and can be preserved by drying. The decrease in the price of this product, mainly due to the utilization of agricultural waste, shows that this product is promising. Today, the black soldier fly has been cultivated in Uzbekistan, and the technology of cultivation in bran has been mastered. In the conditions of Uzbekistan, the cultivation process requires scientifically based information in order to determine which feed substrate is cheap and convenient. The conducted research is aimed at determining the growth and nutritional coefficient of bran and the development cycle and cost of this nutritional substrate. The article presents information from tests on raising black soldier fly hatchlings on bran nourishment substrate. Based on the information gotten, the timing of the advancement of larvae within the bran item, as well as the wholesome esteem of the bran, were indicated.
Statistical analysis of vegetable productivity dynamics of Uzbekistan
Authors: Fayziev Akhtamjon , Ruzmetov Kudrat , Noraliev Nurilla , Turgunov Tolibjon
Published: September 2023

In all fields, there are a lot of random events at a given time. In particular, the process of growing agricultural crops, which is repeated over a certain period, that is, seasonally, is the basis for our analysis as a discrete {Yt,t ∈ T} random dynamic series. This research contributes to the existing literature on agricultural productivity by focusing on the unique context of Uzbekistan. By utilizing a rigorous statistical approach and considering multiple influencing factors, we aim to provide evidence-based recommendations to policymakers and stakeholders for enhancing vegetable productivity and ensuring sustainable agricultural development. In the article, the average yield of {Yt,t ∈ T} vegetables grown in open and closed lands of the Republic of Uzbekistan in 2006-2020 was statistically analyzed using modern methods of mathematical statistics suitable for stable dynamic series, and point and interval statistical estimates were made for vegetable yield with a 95% guarantee. The trend part, which characterizes the main direction of vegetable cultivation, is determined, and the yield obtained from vegetables in the coming years is predicted. The fact that this process has an autocorrelation relationship was determined with the help of statistical criteria, and its important characteristics and laws were studied.
Relationship of silk butterfly lifespan longitude with economic value traits in silk cocoon breeding
Authors: Khudayberdieva Umida , Navruzov Sobir
Published: September 2023

Agriculture plays a key role in the economy of Uzbekistan. Its importance is not limited to the goals of providing food to the population. This is reflected in the cultural heritage and traditions of the people of Uzbekistan in rural areas, in each region of Uzbekistan with its own characteristics and diversity. Today, agriculture in Uzbekistan in general, including cocooning, provides jobs and income to a significant part of the population and remains the driving force of the growth of the economy of Uzbekistan. At the same time, as the economy of Uzbekistan is gradually diversifying, this means that the agrarian sector and the cocooning sector must also be radically reformed, which encourages them to look for new opportunities for competitiveness and sustainable development in the domestic and foreign markets. This requires a new approach to the development of the industry. This article discusses the importance of the role of cocooning in the agricultural sector in the national economy, the strategy for the development of Uzbekistan’s agriculture for 2020-2030, selection and breeding in the development of cocooning, and the role of seed production. In addition, in 2018-2020, the results of the study of the correlation between the life span of butterflies and the valuable traits of their offspring at the Research Institute of Sericulture were cited. The use of the results in science and production practice, as well as the expected results, that is, increasing the quantity of cocoons produced, improving the quality and increasing the competitiveness, are highlighted by the authors.
Growth and development characteristics of introduced varieties of kiwi (Actinidia Deliciosa A.Chev.) in Uzbekistan
Authors: Sultonov Kamolitdin
Published: September 2023

Periods of transition between phenological phases in different kiwi plant varieties: one of the most widely grown fruits today, kiwis are grown extensively in many subtropical and temperate nations. Kiwi farming has recently piqued the curiosity of many fruit producers and landowners in our nation. In order to study the morpho-biological traits of the growth and development of these fruit plant varieties in the soil and climate conditions of Uzbekistan and to scientifically support the possibilities of establishing industrial kiwi gardens on this basis, it is necessary to conduct special scientific research on this plant. In the article, the duration of phenological phases of Kiwi (Actinidia deliciosa (A.Chev.)) varieties Hayward, Monty, Bruno, and pollinator Matua were observed in the climatic conditions of Tashkent region at the Extension center of Tashkent State Agrarian University in Uzbekistan. The sum of active temperatures above 10 °C was calculated for the growth phases of kiwifruit cultivars.
Water quality indicators in high-density cage farming of trout
Authors: Alimova Aziza , Kakhramanov Boymakhmat , Safarova Feruza
Published: September 2023

Trout fishing means raising fish in water whose temperature does not exceed +18°C under completely or partially artificial conditions. Today, several fish belonging to the salmon family are bred in cold water fisheries in the world. These are river trout (Rainbow trout - Oncorhynchus mykiss), brook trout (Brown trout - Salmo trutta), and brown trout (Brook trout - Salvelinus fontinalis). Currently, river trout breeding dominates global production. Its cultivation has been mastered in almost all regions [8]. In the article, the water quality indicators were studied during high-density breeding of trout in the cage method at the “Golden Fish” fishery LLC, located in the Khojakent reservoir in the Tashkent region of Uzbekistan. This includes water temperature, dissolved oxygen content, and water hydrogen potential, as well as information on fish growth, development, nutrition, and reproduction.
Significance of diagnostic of hpv testing and cytoscopic studies in the aspect of gynecological screening detecting cervical pathology in women
Authors: Mamarasulova Dilfuzahon , Azizov Yuriy
Published: September 2023

The purpose of this article was to identify the diagnostic significance of HPV testing and cytoscopic examination in terms of cervical pathology. In the course of this study during 2020-2021. 10,716 women aged 25-65 years were examined, who did not present complaints, indicating gynecological pathology and did not have a history of erosive lesions of the cervix. In the course of the study, the sensitivity, specificity and diagnostic significance of the HPV PCR test and cytoscopic examination were calculated in terms of detecting cervical pathology in women during the screening examination. A colposcopic examination was considered a method of verifying the diagnosis. HPV by PCR in the cervical mucosa during the screening process is detected in 23.77% of women. The frequency of infection decreases with increasing age of the subjects. The combination of positive HPV and cytology as a risk marker does not increase the diagnostic value of primary screening based on the use of methods in isolation.
Clinical and laboratory indicators in children with urolithiasis and the quality of laboratory diagnostics at the stage of inpatient treatment
Authors: Yusupova Nargiza , Shodiyarova Dilfuza , Gullieva Yulduzkhon , Zakirova Baxora , Mukhammadjonov Bakhriddin , Berdiyarova Shokhida
Published: September 2023

The study of changes in biochemical parameters in urolithiasis with different types of stone localization and clinical picture was carried out. All patients in the hospital were examined: general clinical, including a general analysis of urine; biochemical; hematological. The article presents the results of studies of inpatients with a diagnosis of urolithiasis. These studies are relevant in view of the need for constant monitoring of the prescribed laboratory tests by clinicians in the management of these patients. This allows you to increase the level of competence of specialists in the field of laboratory services and for urologists, improves the rationality of prescribing laboratory tests for various nosologies and work with the “Standards of diagnosis and treatment”.
Optimization of surgical treatment of post-burn scar deformities of the lower extremities
Authors: Madaminov S. M. , Fattaxov N. X. , Nuriddinov A. S. , Palvanova M. S. , Sakizboev I. A. , Umurzakov S. M.
Published: September 2023

The article presents the experience of surgical treatment of 172 patients with post-burn scar deformities and defects of the lower extremities. Based on the results obtained, practical recommendations on the optimal choice of methods of operations are given.
Study and evaluation of negative factors affecting employees’ health of glass manufacturing enterprises in Ferghana Region
Authors: Axmadaliev R. U. , Turdiev Sh. M. , Abduvalieva F. T. , Soliyev B.
Published: September 2023

The article describes the measures aimed at studying and eliminating negative factors that affect the health of employees in the glass production enterprise located in Kuvasoy city of Ferghana region. The results of the study showed that the concentration of dust, vapor, gas, aerosols from chemicals in the air of the working area is higher than the AC in all workplaces at the enterprise. In the hot period of the year, the microclimate indicators in the workplace did not meet the hygienic requirements, and the content of dolomite and quartz dust, nitrogen oxides, carbon and sulfur in the emissions of atmospheric air was higher than normal. These conditions have a negative impact on the health of employees, leading to stress in the thermoregulatory process and changes in the functional state of the cardiovascular system.
Mild form of iron deficiency anemia and a latent iron deficiency as a border – line state in infants aged under 2 years
Authors: Shermatov R. M. , Kabilova D. K. , Rayimova Z. M. , Babadjanova Kh. M. , Khaydarov N. S.
Published: September 2023

The mentioned forms of iron deficiency in infants aged 6 mos - 2 yrs were found to be wide – spread, almost blurred clinically, and of high spontaneous reversity. Therefore, failing to affect the children’s growth, physical development and the morbidity rate these disorders could be considered as a border–line stete.
Results the use of minimally invasive surgical methods for the treatment of patients with polytrauma in the Fergana branch of the Rncemp
Authors: Makhmudov N. I. , Dekhkanov K. M. , Botiraliev A. B. , Mirzamatov N. I. , Khozhirahmatov D. K.
Published: September 2023

Retrospective analysis of the anatomical and functional outcomes of surgical treatment of 1024 patients with polytrauma was performed in the trauma department of the FBRSCEMA for the period from 2005 to 2020. High-tech methods of minimally invasive osteosynthesis have been increasingly used in recent years in order to improve the results of treatment of patients with polytrauma. 1340 operations were carried on 1024 (76.4%) patients. The share of minimally invasive surgical interventions was 83.4% (854 operations). In comparison with traditional osteosynthesis, the introduction of new minimally invasive osteosynthesis technologies provides the possibility of earlier performing of surgical fixation of bone fragments, reduces the likelihood of postoperative complications due to minimal surgical trauma, creates optimal conditions for accelerating the healing of fractures, provides early support for the limb and the ability to start an early stage development of movements in the joints of the injured limbs.
Improvement of hemodialysis care in the republic of Uzbekistan
Authors: Djalilova Gulchehra , Asadov Ravshan , Shakirova Dinora , Achilova Jamila
Published: September 2023

Timely and full provision of all patients suffering from chronic renal failure with hemodialysis procedures is one of the priority areas for reforming the healthcare system in Uzbekistan. The article highlights the issues of providing the population with renal replacement therapy and, according to the opinion of the heads of medical institutions, the state of the hemodialysis service in Uzbekistan is disclosed.
Association of MicroRNA-146a expression level and it’s Gene Polymorphism rs2910164 C/G in patients with Rheumatoid Arthritis
Authors: Al-Shemmary Athraa Jaleel , Aldujaili Nawfal Hussein , Alkazzaz Ali Muhammad
Published: September 2023

MicroRNAs are small non-coding RNAs that can regulate a variety of immune functions. MicroRNA146a (miRNA-146a) is regarded as a crucial regulator of posttranscriptional gene expression, suggesting a role in autoimmune disorders. This study was performed to investigate association miRNAs-146a expression and its polymorphisms in patient with Rheumatoid arthritis. The current study includes 120 subjects classified into two main groups: 60 RA patients and 60 healthy controls. Quantitative expression of serum miRNA-146a, as well as its genotyping rs2910164 (C/G) were done to all subjects using real-time PCR and Tetra primer ARMS-PCR respectively. Serum miRNA-146a significantly over expressed in RA patients (fold change 2.59±1.18), compared to the controls (fold change 1.07±0.41), (P=< 0.0001).The receiver operating characteristics (ROC) curve was plotted to compare the expression efficiency of miR-146a showing high sensitivity 91.7 % and high specificity 91.1 %, AUC 0.95, (95% CI 0.91-0.99), the cut off value was (1.57). On the other hand MiRNA-146a (rs2910164) genotyping revealed that no significant variation between the RA patients in the comparison with the control group under all co-dominant model heterozygous genotype (C/G), co-dominant model homozygous genotype (G/G), dominant pattern (C/G+G/G) genotypes, recessive model (G/G) genotype. Analysis of the allele frequencies no statistically significant differences between patients and controls. Conclusion miRNAs-146a expression can be used as diagnostic markers for RA patients and miRNA-146a rs2910164 C/G not associated with RA susceptibility. The C allele of miRNA-146a (rs2910164) can be considered to be protective.
Immune Response, Gene sequence to Contagious Ecthyma Virus (Orfv) Infected Lambs in Diyala Governorate, Iraq
Authors: Yuness Hiba Qayes , Abood Walaa Najm
Published: September 2023

Contagious ecyhyma Known (Orf, contagious pustular dermatitis, sore mouth, scabby mouth) a disease spreads easily and brought by the epitheliotropic. It’s endemic around the world and has a serious economic impact. This study aimed to understand the immune response mechanisms of the lambs to defense against Contagious ecthyma virus and molecular detection of the virus with the determining the sequence and mutant of the viral genome to 91 lambs (41 has clinical signs of Orfv and 50 control do not have clinical sign of Orfv) for the period extended from September 2022 to April 2023. Blood samples were collected from all above groups to apply for detection the level of IgM, IgG, IL-10, and IFN-γ of Orfv by ELISA test. Positive Orfv IgM was 75.6% infected lamb and 72% none infected, and positive Orfv IgG was 90.2% infected lamb and 88% none infected. The result was showed the level of IL-10 a significant increasing, in all Lambs positive IgM and IgG compared with control group. IFN-γ level showed non significant differences between all Lambs positive IgM and IgG compared with control group. Molecular detection of Orfv result was confirmed the positivity of all samples positive Orfv IgM. And the sequencing of the Orfv DNA showed a mutant in the some Allel compared with References strain registered at NCBI. Concluded: high prevalence of Orfv among lambs and happened mutants to the viral genome increased the virus’s virulence by affecting the immune response.
The prevalence study of patients infected with pyelonephritis by in Al-Najaf Governorate, Iraq
Authors: Muhammad-Baqir Bashaer M. , Fattah Abdalmahdi Abdalrasul , Al-janabi Dhafer Rahman Abed , Aljanaby Ahmed Abduljabbar Jaloob
Published: September 2023

The study aimed at the prevalence of pyelonephritis and its association with some kidney diseases, function or structure, in Iraq, specifically in the province of Najaf, for a period of 16 months, from 2/1/2022 to 1/5/2023, where 1255 samples of males and females of different ages were collected, and the patients were divided into several groups depending on time, gender, residence, age and disease. Regarding the disease, there are individuals who only have pyelonephritis and their number was 277 (18%), while the rest of the patients were 1028 (82%) who had kidney problems, whether functional or immunological, which is kidney failure and renal syndrome, kidney transplantation and lupus erythematous. The most common is pyelonephritis associated with renal failure or insufficiency, with a number of 768.)%95( Also, the results showed that the month of April for the year 2022 obtained the most samples, with a number of 109 (8.69%) samples. with regard to gender, females were generally more susceptible to infection than males, reaching 55%. As for housing, most patients lived in urban areas. In contrast to rural areas, where their percentage was low (40%), and therefore people should be educated and urged to review the hospital and specialist doctors when they feel any symptoms related to the kidneys, so that they do not suffer from failure later.
Opportunities for monitoring the comfort of children living in substitute families for sustainable social development
Authors: Zaluzhnaya Maria , Bayer Elena , Chekalenko Elena , Grigoryan Narine , Illarionova Alla
Published: September 2023

This article reflects the monitoring indicators from the research of living conditions in substitute families in the South of Russia. The authors present some study results of the living comfort in a substitute family, namely the relationships with foster parents; interaction with blood and other foster children in the family; the psycho-emotional state; physical, mental, and emotional violence in a foster family; the desire to live in a substitute family. The monitoring was carried out among 76 foster children being brought up in substitute families of the Azov city and the Azov district of the Rostov region and accompanied by the Azov Child Care Centre. The results obtained are of great importance for specialists of support services for substitute families, as well as researchers whose scientific interest is focused on studying substitute family care in Russia. The research has been carried out within the framework of the Ministry of General and Vocational Education order of the Rostov Region No. 747 of 28 July 2022 “On measures to assess the level of comfort of a child’s stay in a substitute family”.