bluuebunny/crossref_metadata_2025 huggingface dataset:
Including clover and herb species in grazing forages – effects on milk production, milk processability and milk fatty acid profile of late lactation dairy cows supplemented with grass silage and concentrate
Authors: McCarthy K. M. , Walsh N. , Serra E. , Fahey A. G. , Lynch M. B. , Pierce K. M. , Boland T. M. , Sheridan H. , Markiewicz-Keszycka M. , Mulligan F. J.
Published: February 2024

Milk production declines as dairy cows enter late lactation, resulting in reduced milk quality and negatively impacting milk processability, such as rennet coagulation time (RCT), milk pH and ethanol stability (ES), leading to seasonality issues for milk processors. Multispecies forages, containing grass, legume and herb species, require lower N inputs and are of interest to dairy farmers. However, little is known about the effect of grazing multispecies forages on milk processability characteristics in late lactation dairy cows. Forty-five autumn-calving dairy cows in late lactation were allocated to 1 of 3 grazing forages; perennial ryegrass (PRG; Lolium perenne), perennial ryegrass and white clover (Trifolium pratense) (PRGWC), and a 6 – species multispecies forage (MULTI) containing perennial ryegrass, timothy (Phleum pratense), white clover, red clover (Trifolium repens), chicory (Cichorium intybus) and plantain (Plantago lanceolata). Cows were allocated 12 kg DM grazed forage and supplemented with a grass – silage TMR and concentrate. Forage DMI was significantly lower for cows grazing PRG. Milk yield increased when cows grazed PRGWC (18.07 kg/d) and MULTI (17.84 kg/d) compared to PRG (16.08 kg/d). Milk RCT (mins) and ES (%) were unaffected by treatment. However, offering cows PRGWC and MULTI increased the concentration of C18:2 cis – 9, 12 and C18:3 cis – 9, 12, 15 in milk compared to PRG. Compared to PRG, grazing forages containing clover and herb species improved milk yield and beneficially altered milk fatty acid profile in late lactation dairy cows without negatively impacting milk processability.
Calibrated heating rate measurements using electric-field-induced electron extraction in ultracold neutral plasmas
Authors: Guthrie John M. , Jiang Puchang , Roberts Jacob L.
Published: February 2024

The heating rate of plasma electrons induced by external fields or other processes can be used as an experimental tool to measure fundamental plasma properties such as electrical conductivity or electron–ion collision rates. We have developed a technique that can measure electron heating rates in ultracold neutral plasmas (UNPs) with$\sim 10\,\%$precision while simultaneously referencing the measurement to a calibrated amount of heating. This technique uses a sequence of applied electric fields in four sections: to control the ratio of electrons to ions in the UNP; to provide a time for the application of fields that cause electron heating and subsequent thermalization of the electrons after the application of those fields; to extract electrons from the UNP using a method sensitive to electron temperature that allows the measurement of electron heating; and to extract the remaining electrons to measure the total electron (and therefore ion) number. The primary signal used to measure the heating rate is the measurement of the number of electrons that escape in the third section of the experiment as a larger number of escaping electrons indicates a larger amount of heating. We illustrate the use of this technique by measuring electron heating caused by high-frequency radiofrequency (RF) fields. In addition to the main technique, several subtechniques to calibrate the electron temperature, electron density, amount of heating and applied RF field amplitude were developed as well.
Outbreak of Mycoplasma pneumoniae pneumonia in hospitalized patients: Who is concerned? Nord Franche-Comté Hospital, France, 2023–2024
Authors: Zayet Souheil , Poloni Samantha , Plantin Julie , Hamani Abdoulaye , Meckert Yann , Lavoignet Charles-Eric , Gendrin Vincent , Klopfenstein Timothée
Published: February 2024

We report an outbreak of confirmed Mycoplasma pneumoniae community-acquired pneumonia (CAP) in Nord Franche-Comté Hospital, France, from 14 November 2023 to 31 January 2024. All 13 inpatients (11 adults with a mean age of 45.5 years and 2 children) were diagnosed with positive serology and/or positive reverse transcription polymerase chain reaction (RT-PCR) on respiratory specimens. All patients were immunocompetent and required oxygen support with a mean duration of oxygen support of 6.2 days. Two patients were transferred to the intensive care unit (ICU) but were not mechanically ventilated. Patients were treated with macrolides (n = 12, 92.3%) with recovery in all cases. No significant epidemiological link was reported in these patients.
The relationship between social media addiction and emotional appetite: a cross-sectional study among young adults in Turkey
Authors: Sevim Sumeyra , Gumus Damla , Kizil Mevlude
Published: February 2024

Objective:

The present study focused on the relationship between addiction to social media (SM) and emotional appetite in young adults.

Design:

Cross-sectional online survey.

Setting:

The Bergen Social Media Addiction Scale (BSMAS) and Emotional Appetite Questionnaire (EMAQ) were used, and the duration and frequency of SM tools usage were analysed.

Participants:

Five hundred and twenty-four participants (144 men and 380 women) aged between 18 and 25 years.

Results:

The mean of SM usage duration of participants was 3·2 ± 2·2 h per d along with a mean of BSMAS score of 16·1 ± 5·9. Concerning emotional appetite, the mean scores for positive and negative aspects of EMAQ were 4·4 ± 1·9 and 3·1 ± 1·2, respectively. The predominant SM tools were YouTube (92·6 %) and Instagram (90·3 %). Notably, a significant association was observed between SM addiction and the frequency of access to YouTube, Instagram, and Twitter, with addiction levels increasing as access frequency rose (P< 0·01).

Conclusion:

This study demonstrated a possible relationship between SM addiction and emotional appetite among young adults. However, further research with more prominent participants and a lengthier follow-up duration is necessary to elucidate how SM tools affect eating behaviour.
Modelling and commissioning validation of eclipse conical cone collimator for stereotactic radiosurgery using Monte Carlo simulation
Authors: Shende Ravindra , Dhoble S. J. , Saroj Dinesh , Gupta Gourav
Published: February 2024

Purpose:

The miniaturized conical cones for stereotactic radiosurgery (SRS) make it challenging in measurement of dosimetric data needed for commissioning of treatment planning system. This study aims at validating dosimetric characteristics of conical cone collimator manufactured by Varian using Monte Carlo (MC) simulation technique.

Methods & Material:

Percentage depth dose (PDD), tissue maximum ratio (TMR), lateral dose profile (LDP) and output factor (OF) were measured for cones with diameters of 5mm, 7·5mm, 10mm, 12·5 mm, 15 mm and 17·5 mm using EDGE detector for 6MV flattening filter-free (FFF) beam from Truebeam linac. Similarly, MC modelling of linac for 6MVFFF beam and simulation of conical cones were performed in PRIMO. Subsequently, measured beam data were validated by comparing them with results obtained from MC simulation.

Results:

The measured and MC-simulated PDDs or TMRs showed close agreement within 3% except for cone of 5mm diameter. Deviations between measured and simulated PDDs or TMRs were substantially higher for 5mm cone. The maximum deviations at depth of 10cm, 20cm and at range of 50% dose were found 4·05%, 7·52%, 5·52% for PDD and 4·04%, 7·03%, 5·23% for TMR with 5mm cone, respectively. The measured LDPs acquired for all the cones showed close agreement with MC LDPs except in penumbra region around 80% and 20% dose profile. Measured and MC full-width half maxima of dose profiles agreed with nominal cone size within ± 0·2 mm. Measured and MC OFs showed excellent agreement for cone sizes ≥10 mm. However, deviation consistently increases as the size of the cone gets smaller.

Findings:

MC model of conical cones for SRS has been presented and validated. Very good agreement was found between experimentally measured and MC-simulated data. The dosimetry dataset obtained in this study validated using MC model may be used to benchmark beam data measured for commissioning of SRS for cone planning.
Relationship Between Actual Intelligence & the CAMCOG-R in Cognitively Normal Elders
Authors: Heinik Jeremia
Published: February 2024

Abstract: We examined (1) the relationship between actual intelligence and the CAMCOG-R performance in cognitively normal elders and (2) the presumed impact of age and education on the relationship. Our retrospective study of 94 participants assessed in a specialized setting, measuring actual intelligence (general and specific) with the Wechsler Adult Intelligence Scale-III, the Full-Scale Intelligence Quotient (WAIS-III FSIQ), and the specific subtests thereof. The CAMCOG-R correlated largely with FSIQ (.629, p < .001; .708 when controlled for age). The CAMCOG-R’s scores increased across three different IQ levels as IQ increased. FSIQ accounted for 40% of the CAMCOG-R’s variability. Combined, FSIQ and age accounted for 59% of the CAMCOG-R’s variability. FSIQ had a stronger weight than age (β: .644 and −.439, respectively). Regression analyses with FSIQ’s subtests, age and education, found the best-equilibrated model to include Information, age, and Picture Completion. Combined, they accounted for 55% of the CAMCOG-R’s variability. Information received the strongest weight (β: .411). Overall, education was nonsignificant. Thus, a significant relationship existed primarily between general intelligence and the CAMCOG-R and, to a lesser extent, between the above-mentioned subtests of intelligence and the CAMCOG-R. Adding age increased the prediction rate. Actual intelligence and age should be considered when interpreting the CAMCOG-R’s scores. The practical implementation of the intelligence factor is complex.
Peer-Recommended Coping Strategies for Individuals Living With	Alopecia Areata
Authors: Huck Garrett E. , Brickham Dana , Shelton Shaina
Published: February 2024

Abstract: Background: Alopecia areata (AA) is a chronic immunological disease characterized by hair loss on the scalp and/or body. Medical treatments are frequently ineffective, leaving many individuals with little hope for hair regrowth. Despite high rates of psychological turmoil experienced by people living with AA, little consideration is given to the unique impact of the condition and the potential benefits of coping approaches. Aims: The purpose of this study was to establish a foundation of strategies for coping with AA as recommended by people currently living with the diagnosis. Method: An international sample of 190 participants shared perspectives on types of strategies they believe would be useful for living with AA. A qualitative content analysis approach was used to code and group participant responses. Results: Frequently identified strategies included various forms of social support and strategies for social navigation, perspective-shifting, cosmetic strategies and procedures, and accessing medical and psychological interventions. Limitations: Participants were limited to a largely female convenience sample. The findings were not associated with real-life outcomes, only anecdotal recommendations. Conclusion: The findings of the present study further support prior research yet offer unique perspectives as well.
How Hydrothermal Cooling and Magmatic Sill Intrusions Control Flip‐Flop Faulting at Ultraslow‐Spreading Mid‐Ocean Ridges
Authors: Glink Arne , Hasenclever Jörg
Published: February 2024

“Flip‐flop” detachment mode represents an endmember type of lithosphere‐scale faulting observed at almost amagmatic sections of ultraslow‐spreading mid‐ocean ridges. Recent numerical experiments using an imposed steady temperature structure show that an axial temperature maximum is essential to trigger flip‐flop faults by focusing flexural strain in the footwall of the active fault. However, ridge segments without significant melt budget are more likely to be in a transient thermal state controlled, at least partly, by the faulting dynamics themselves. Therefore, we investigate which processes control the thermal structure of the lithosphere and how feedbacks with the deformation mechanisms can explain observed faulting patterns. We present results of 2‐D thermo‐mechanical numerical modeling including serpentinization reactions and dynamic grain size evolution. The model features a novel form of parametrized hydrothermal cooling along fault zones as well as the thermal and rheological effects of periodic sill intrusions. We find that the interplay of hydrothermal fault zone cooling and periodic sill intrusions in the footwall facilitates the flip‐flop detachment mode. Hydrothermal cooling of the fault zone pushes the temperature maximum into the footwall, while intrusions near the temperature maximum further weaken the rock and promote the formation of new faults with opposite polarity. Our model allows us to put constraints on the magnitude of two processes, and we obtain most reasonable melt budgets and hydrothermal heat fluxes if both are considered. Furthermore, we frequently observe two other faulting modes in our experiments complementing flip‐flop faulting to yield a potentially more robust alternative interpretation for existing observations.
A Global Survey of Gravitationally Deformed Volcanoes on Venus
Authors: Hahn Rebecca M. , Byrne Paul K.
Published: February 2024

Gravitational instabilities can develop at volcanoes of any size and in any geological setting and can lead to various types of volcano deformation, ranging from small‐scale landslides on the flanks of the edifice to large, deep‐seated sector collapses. As volcanoes grow, they impose an increasing load on the underlying basement, which can result in styles of gravitational deformation where the edifice sags or spreads outward under its own weight. In this study, we utilize our previously developed global catalog of volcanoes on Venus to analyze a subset of edifices that appears to have undergone gravitational deformation. We identify 162 volcanoes that display morphological evidence for gravitational deformation and classify them into four main categories based on associated deformational structures: landsliding, sector collapse, spreading, and sagging. Landsliding of volcano flanks or full sector collapse are the most common and geographically widespread deformational styles on Venus, and account for ∼64% of our data set. Edifices exhibiting structures linked to volcano spreading and sagging are relatively rare; nonetheless, we note for the first time on Venus the presence on a shield volcano of flank terraces, structures linked to sagging. We find that deformed volcanoes are distributed globally, are found at a range of elevations, are spatially proximal to a variety of tectonic structures, and are associated with various crustal thickness values, which together suggest that there are numerous drivers of volcano deformation on Venus.
Farnesoid X receptor promotes non-small cell lung cancer metastasis by activating Jak2/STAT3 signaling via transactivation of IL-6ST and IL-6 genes
Authors: Jin Xiuye , Shang Bin , Wang Junren , Sun Jian , Li Jing , Liang Bin , Wang Xingguang , Su Lili , You Wenjie , Jiang Shujuan
Published: February 2024

Metastasis accounts for the majority of cases of cancer recurrence and death in patients with advanced non-small cell lung cancer (NSCLC). Farnesoid X Receptor (FXR) is a bile acid nuclear receptor that was recently found to be upregulated in NSCLC tissues. However, whether and how FXR regulates NSCLC metastasis remains unclear. In the present study, it was found that FXR promoted the migration, invasion, and angiogenic ability of NSCLC cells in vitro, and increased NSCLC metastasis in a mouse model in vivo. Mechanistic investigation demonstrated that FXR specifically bound to the promoters of IL-6ST and IL-6 genes to upregulate their transcription, thereby leading to activation of the Jak2/STAT3 signaling pathway, which facilitated tumor migration, invasion, and angiogenesis in NSCLC. Notably, Z-guggulsterone, a natural FXR inhibitor, significantly reduced FXRhigh NSCLC metastasis, and decreased the expression of FXR, IL-6, IL-6ST, and p-STAT3 in the mouse model. Clinical analysis verified that FXR was positively correlated with IL-6, IL-6ST and p-STAT3 expression in NSCLC patients, and was indicative of a poor prognosis. Collectively, these results highlight a novel FXR-induced IL-6/IL-6ST/Jak2/STAT3 axis in NSCLC metastasis, and a promising therapeutic means for treating FXRhigh metastatic NSCLC.
Comparison of the effects of renal denervation at early or advanced stages of hypertension on cardiac, renal, and adipose tissue pathology in Dahl salt-sensitive rats
Authors: Nagata Kohzo , Tagami Kaito , Okuzawa Touko , Hayakawa Misaki , Nomura Akane , Nishimura Tomo , Ikeda Katsuhide , Kitada Kento , Kobuchi Shuhei , Fujisawa Yoshihide , Nishiyama Akira , Murohara Toyoaki
Published: February 2024

Renal denervation (RDN) has emerged as a novel therapy for drug-resistant hypertension. We here examined the effects of RDN at early versus advanced stages of hypertension on blood pressure and organ pathology in rats with salt-sensitive hypertension. Dahl salt-sensitive (DahlS) rats fed an 8% NaCl diet from 6 weeks of age were subjected to RDN (surgical ablation and application of 10% phenol in ethanol) or sham surgery at 7 (early stage) or 9 (advanced stage) weeks and were studied at 12 weeks. RDN at early or advanced stages resulted in a moderate lowering of blood pressure. Although RDN at neither stage affected left ventricular (LV) and cardiomyocyte hypertrophy, it ameliorated LV diastolic dysfunction, fibrosis, and inflammation at both stages. Intervention at both stages also attenuated renal injury as well as downregulated the expression of angiotensinogen and angiotensin-converting enzyme (ACE) genes and angiotensin II type 1 receptor protein in the kidney. Furthermore, RDN at both stages inhibited proinflammatory gene expression in adipose tissue. The early intervention reduced both visceral fat mass and adipocyte size in association with downregulation of angiotensinogen and ACE gene expression. In contrast, the late intervention increased fat mass without affecting adipocyte size as well as attenuated angiotensinogen and ACE gene expression. Our results thus indicate that RDN at early or late stages after salt loading moderately alleviated hypertension and substantially ameliorated cardiac and renal injury and adipose tissue inflammation in DahlS rats. They also suggest that cross talk among the kidney, cardiovascular system, and adipose tissue may contribute to salt-sensitive hypertension.
Are the results of open randomised controlled trials comparing antipsychotic drugs in schizophrenia biased? Exploratory meta- and subgroup analysis
Authors: Leucht Stefan , Siafis Spyridon , Schneider-Thoma Johannes , Tajika Aran , Priller Josef , Davis John M. , Furukawa Toshi A.
Published: February 2024

A recent meta-epidemiological study did not reveal major differences between the results of blinded and open randomised-controlled trials (RCTs). Fewer patients may consent to double-blind RCTs than to open RCTs, compromising generalisability, making this question very important. However, the issue has not been addressed in schizophrenia. We used a database of randomised, acute-phase antipsychotic drug trials. Whenever at least one open and one blinded RCT was available for a comparison of two drugs, we contrasted the results by random-effects meta-analysis with subgroup tests. The primary outcome was overall symptoms as measured by the Positive and Negative Syndrome Scale, supplemented by seven secondary efficacy and side-effect outcomes. We also examined whether open RCTs were biased in favour of more recently introduced antipsychotics, less efficacious or more prone to side-effects antipsychotics, and pharmaceutical sponsors. 183 RCTs (155 blinded and 28 open) with 34715 participants comparing two active drugs were available. The results did not suggest general differences between open and blinded RCTs, which examined two active drugs. Only 12 out of 122 subgroup tests had a p-value below 0.1, four below 0.05, and if a Bonferroni correction for multiple tests had been applied, only one would have been significant. There were some exceptions which, however, did not always confirm the originally hypothesized direction of bias. Due to the relatively small number of open RCTs, our analysis is exploratory, but this fundamental question should be given more scientific attention. Currently, open RCTs should be excluded from meta-analyses, at least in sensitivity analyses.
Profiles of mathematical deficits in children with dyslexia
Authors: Pedemonte B. , Pereira C. W. , Borghesani V. , Ebbert M. , Allen I. E. , Pinheiro-Chagas P. , De Leon J. , Miller Z. , Tee B. L. , Gorno-Tempini M. L.
Published: February 2024

Despite a high rate of concurrent mathematical difficulties among children with dyslexia, we still have limited information regarding the prevalence and severity of mathematical deficits in this population. To address this gap, we developed a comprehensive battery of cognitive tests, known as the UCSF Mathematical Cognition Battery (MCB), with the aim of identifying deficits in four distinct mathematical domains: number processing, arithmetical procedures, arithmetic facts retrieval, and geometrical abilities. The mathematical abilities of a cohort of 75 children referred to the UCSF Dyslexia Center with a diagnosis of dyslexia, along with 18 typically developing controls aged 7 to 16, were initially evaluated using a behavioral neurology approach. A team of professional clinicians classified the 75 children with dyslexia into five groups, based on parents’ and teachers’ reported symptoms and clinical history. These groups included children with no mathematical deficits and children with mathematical deficits in number processing, arithmetical procedures, arithmetic facts retrieval, or geometrical abilities. Subsequently, the children underwent evaluation using the MCB to determine concordance with the clinicians’ impressions. Additionally, neuropsychological and cognitive standardized tests were administered. Our study reveals that within a cohort of children with dyslexia, 66% exhibit mathematical deficits, and among those with mathematical deficits, there is heterogeneity in the nature of these deficits. If these findings are confirmed in larger samples, they can potentially pave the way for new diagnostic approaches, consistent subtype classification, and, ultimately personalized interventions.
Herbivorous sea urchins (Echinometra mathaei) support resilience on overfished and sedimented tropical reefs
Authors: Fong Caitlin R. , Smith Nefertiti , Catalan Elijah , Caraveo Blanca Alvarez , Barber Paul H. , Fong Peggy
Published: February 2024

Human impacts are dramatically changing ecological communities, motivating research on resilience. Tropical reefs are increasingly undergoing transitions to short algal turf, a successional community that mediates either recovery to coral by allowing recruitment or transitions to longer turf/macroalgae. Intense herbivory limits turf height; subsequently, overfishing erodes resilience of the desirable coral-dominated reef state. Increased sedimentation also erodes resilience through smothering and herbivory suppression. In spite of this critical role, most herbivory studies on tropical reefs focus on fishes, and the contribution of urchins remains under-studied. To test how different herbivory and sedimentation scenarios impact turf resilience, we experimentally simulated, in situ, four future overfishing scenarios derived from patterns of fish and urchin loss in other reef systems and two future sedimentation regimes. We found urchins were critical to short turf resilience, maintaining this state even with reduced fish herbivory and increased sediment. Further, urchins cleared sediment, facilitating fish herbivory. This study articulates the likelihood of increased reliance on urchins on impacted reefs in the Anthropocene.
The phylogeographic journey of a plant species from lowland to highlands during the Pleistocene
Authors: Soares Luana Sousa , Freitas Loreta B.
Published: February 2024

Phylogeographic history refers to how species evolve and diversify in response to historical, ecological, and demographic factors. The climate fluctuation during the Pleistocene period marked a crucial time in shaping many species’ distribution and genetic structure, particularly those from southern South American grasslands. This work investigated the phylogeographic history of a highland grassland, Petunia altiplana T. Ando & Hashim. (Solanaceae), its diversity, and geographic distribution using a population genomic approach based on RAD-seq data. Our results indicated that, during the Pleistocene, when the grasslands expanded to highlands, the lowland populations of P. altiplana reached the higher open fields, enlarging their geographic distribution. We found that the P. altiplana genetic diversity followed the geographic division into eastern (E) and western (WE) population groups, with a subtle division in the E group regarding the Pelotas River headwater. The results also showed that isolation by distance was the main divergence pattern, with elevation playing a pivotal role in shaping WE and E groups. Our findings indicated that lowland-adapted populations quickly colonized highlands during the late Pleistocene.
Coherent control of two Jaynes–Cummings cavities
Authors: Castaños-Cervantes L. O. , Procopio Lorenzo M. , Enríquez Marco
Published: February 2024

We uncover new features on the study of a two-level atom interacting with one of two cavities in a coherent superposition. The Jaynes-Cummings model is used to describe the atom–field interaction and to study the effects of quantum indefiniteness on such an interaction. We show that coherent control of the two cavities in an undefined manner allows novel possibilities to manipulate the atomic dynamics on demand which are not achievable in the conventional way. In addition, it is shown that the coherent control of the atom creates highly entangled states of the cavity fields taking a Bell-like or Schrödinger-cat-like state form. Our results are a step forward to understand and harness quantum systems in a coherent control, and open a new research avenue in the study of atom–field interaction exploiting quantum indefiniteness.
Synthesis of 2D layered transition metal (Ni, Co) hydroxides via edge-on condensation
Authors: Ping Lu , Minarik Gillian E. , Gao Hongze , Cao Jun , Li Tianshu , Kitadai Hikari , Ling Xi
Published: February 2024

Layered transition metal hydroxides (LTMHs) with transition metal centers sandwiched between layers of coordinating hydroxide anions have attracted considerable interest for their potential in developing clean energy sources and storage technologies. However, two-dimensional (2D) LTMHs remain largely understudied in terms of physical properties and applications in electronic devices. Here, for the first time we report > 20 μm α-Ni(OH)2 2D crystals, synthesized from hydrothermal reaction. And an edge-on condensation mechanism assisted with the crystal field geometry is proposed to understand the 2D intra-planar growth of the crystals, which is also testified through series of systematic comparative studies. We also report the successful synthesis of 2D Co(OH)2 crystals (> 40 μm) with more irregular shape due to the slightly distorted octahedral geometry of the crystal field. Moreover, the detailed structural characterization of synthesized α-Ni(OH)2 are performed. The optical band gap energy is extrapolated as 2.54 eV from optical absorption measurements and the electronic bandgap is measured as 2.52 eV from reflected electrons energy loss spectroscopy (REELS). We further demonstrate its potential as a wide bandgap (WBG) semiconductor for high voltage operation in 2D electronics with a high breakdown strength, 4.77 MV/cm with 4.9 nm thickness. The successful realization of the 2D LTMHs opens the door for future exploration of more fundamental physical properties and device applications.
Environmental and mineralogical studies on the stream sediments of Baltim–El Burullus coastal plain, North Delta, Egypt
Authors: Sallam A. M. , Faheim A. A. , El-Elshafiey Z. A. , Azeem M. M. Abdel , El Feky M. G. , Hanfi M. Y.
Published: February 2024

This work is mainly concerned with the effect of anthropogenic activities and natural radioactivity due to the presence of highly radioactive black sand spots, factory construction, and shipping, in addition to other activities like agriculture on human beings. Forty samples were collected along Baltim–El Burullus coastal plain to detect the effect of these problems and determine the suggested solutions. The black sand of the Baltim–El Burullus coastal plain exhibits a considerable amount of economically heavy minerals, their ratio relative to the bulk composition in the investigated samples ranges from 3.18 to 10.5% with an average of 5.45%. The most important of them are magnetite, ilmenite, rutile, leucoxene, garnet, zircon and monazite. The existence of some radioactive-bearing accessory mineral deposits like zircon and monazite led to measuring the naturally occurring radionuclides 226Ra, 232Th and 40K to evaluate the excess lifetime cancer risk (ELCR). The results showed that these concentrations are 19.1 ± 9.73, 14.7 ± 9.53 and 211 ± 71.34 Bq kg−1 were lower than the corresponding reported worldwide average of 35, 45, and 412 Bq kg−1 for each radionuclide (226Ra, 232Th, and 40 K). The gamma hazard indices such as absorbed dose rate (Dair), the annual effective dose (AED), and excess lifetime cancer risk (ELCR) factor were computed in the investigated sediments and all the results were found (Dair = 26.4 nGy h−1, AED = 0.03 mSv year−1, ELCR = 0.0001) to be lower than the values suggested by the United Nations Scientific Committee on the effect of Atomic Research (59 nGy h−1, 0.07 mSv year−1 and 0.0029 for Dair, AED and ELCR, respectively). The study suggests that the black sand is safe to use in various infrastructure applications at Baltim–El Burullus coastal plain. The levels of radioactivity are not high enough to pose a risk to human health.
Ocean warming events resilience capability in underwater computing platforms
Authors: Periola A. A. , Alonge A. A. , Ogudo K. A.
Published: February 2024

Underwater data centers (UDCs) use the ocean’s cold-water resources for free cooling and have low cooling costs. However, UDC cooling is affected by marine heat waves, and underwater seismic events thereby affecting UDC functioning continuity. Though feasible, the use of reservoirs for UDC cooling is non–scalable due to the high computing overhead, and inability to support continuity for long duration marine heat waves. The presented research proposes a mobile UDC (capable of migration) to address this challenge. The proposed UDC migrates from high underwater ground displacement ocean regions to regions having no or small underwater ground displacement. It supports multiple client underwater applications without requiring clients to develop, deploy, and launch own UDCs. The manner of resource utilization is influenced by the client’s service level agreement. Hence, the proposed UDC provides resilient services to the clients and the requiring applications. Analysis shows that using the mobile UDC instead of the existing reservoir UDC approach enhances the operational duration and power usage effectiveness by 8.9–48.5% and 55.6–70.7% on average, respectively. In addition, the overhead is reduced by an average of 95.8–99.4%.
Association of physical functional activity impairment with severity of sarcopenic obesity: findings from National Health and Nutrition Examination Survey
Authors: Huang Shih-Wei , Lee Yu-Hao , Liao Chun-De , Escorpizo Reuben , Liou Tsan-Hon , Lin Hui-Wen
Published: February 2024

We aim to clarify the relationship between low skeletal muscle mass and varying levels of adiposity and to identify the types of physical function impairments associated with sarcopenic obesity (SO). This study examined cross-sectional data from the National Health and Nutrition Examination Survey with whole-body dual-energy X-ray absorptiometry (DXA) scans. The data included age, gender, DXA-assessed body composition, and physical functional activity with performing daily tasks by questionnaire. We subdivided the data by body composition into a non-SO group and a SO group (ASMI 0–49.99% and FMI of 50–100%), after which the SO data were subdivided into three classes. A higher class indicated higher adiposity and lower muscle mass. The physical function impairment of the two groups was compared. Our study examined 7161 individuals, of which 4907 did not have SO and 2254 had SO, and their data were further divided into three classes (i.e., class I, 826 individuals; class II, 1300 individuals; and class III, 128 individuals). Significant differences in demographics and DXA parameters were identified between the non-SO and SO groups (P < 0.001); the individuals with SO were older, included more women, and exhibited high adiposity and less lean muscle mass. The individuals with class III SO exhibited greater differences and reported more difficulty in performing daily activities. The individuals with class III SO exhibited the most severe physical function impairment. Our study highlights the considerable difficulties encountered by individuals with SO in performing daily activities. Given this finding, customized rehabilitation strategies should be implemented to improve the quality of life of individuals with SO.
Identification of immunogenic cell death-related genes involved in Alzheimer’s disease
Authors: Wang Rui , Du Yaming , Shao Wei , Wang Junli , Liu Xin , Xu Xinzi , Chen Guohua , Sun Yixuan
Published: February 2024

Alzheimer's disease (AD) is the leading cause of dementia worldwide, with recent studies highlighting the potential role of immunogenic cell death (ICD) in the pathogenesis of this neurodegenerative disorder. A total of 52 healthy controls and 64 patients with AD were included. Compared to the controls, the patients with AD exhibited 2392 differentially expressed genes (DEGs), of which 1015 and 1377 were upregulated and downregulated genes, respectively. Among them, nine common genes were identified by intersecting the AD-related module genes with the DEGs and ICD-associated genes. Gene ontology (GO)analysis further revealed “positive regulation of cytokine production” as the most significant term. Moreover, the enriched molecular functions were primarily related to the inflammatory body complex, while the overlapping genes were significantly enriched in lipopolysaccharide binding. Kyoto encyclopedia of genes and genomes (KEGG) analysis also indicated that these overlapping genes were mainly enriched in immunity, inflammation, and lipid metabolism pathways. Furthermore, the following four hub genes were detected using machine learning algorithms: P2RX7, HSP90AA1, NT5E, and NLRP3. These genes demonstrated significant differences in expression between the AD and healthy control groups (P < 0.05). Additionally, the area under the curve values of these four genes were all > 0.7, indicating their potential diagnostic value for AD. We further validated the protein levels of these four genes in the hippocampus of 3xTg-AD and C57BL/6J mice, showing P2RX7 and HSP90AA1 expression levels consistent with the previously analyzed trends. Finally, the single-sample gene set enrichment analysis (ssGSEA) algorithm provided additional evidence by demonstrating the crucial role of immune cell infiltration and its link with the hub genes in AD progression. Our study results suggest that ICD-mediated elevation of HSP90AA1 and P2RX7 levels and the resulting induction of tau hyperphosphorylation and neuroinflammation are vital in the AD pathogenic mechanism.
Graph neural network recommendation algorithm based on improved dual tower model
Authors: He Qiang , Li Xinkai , Cai Biao
Published: February 2024

In this era of information explosion, recommendation systems play a key role in helping users to uncover content of interest among massive amounts of information. Pursuing a breadth of recall while maintaining accuracy is a core challenge for current recommendation systems. In this paper, we propose a new recommendation algorithm model, the interactive higher-order dual tower (IHDT), which improves current models by adding interactivity and higher-order feature learning between the dual tower neural networks. A heterogeneous graph is constructed containing different types of nodes, such as users, items, and attributes, extracting richer feature representations through meta-paths. To achieve feature interaction, an interactive learning mechanism is introduced to inject relevant features between the user and project towers. Additionally, this method utilizes graph convolutional networks for higher-order feature learning, pooling the node embeddings of the twin towers to obtain enhanced end-user and item representations. IHDT was evaluated on the MovieLens dataset and outperformed multiple baseline methods. Ablation experiments verified the contribution of interactive learning and high-order GCN components.
The chemical succession in anoxic lake waters as source of molecular diversity of organic matter
Authors: Lau Maximilian P. , Hutchins Ryan H. S. , Tank Suzanne E. , A. del Giorgio Paul
Published: February 2024

The aquatic networks that connect soils with oceans receive each year 5.1 Pg of terrestrial carbon to transport, bury and process. Stagnant sections of aquatic networks often become anoxic. Mineral surfaces attract specific components of organic carbon, which are released under anoxic conditions to the pool of dissolved organic matter (DOM). The impact of the anoxic release on DOM molecular composition and reactivity in inland waters is unknown. Here, we report concurrent release of iron and DOM in anoxic bottom waters of northern lakes, removing DOM from the protection of iron oxides and remobilizing previously buried carbon to the water column. The deprotected DOM appears to be highly reactive, terrestrially derived and molecularly distinct, generating an ambient DOM pool that relieves energetic constraints that are often assumed to limit carbon turnover in anoxic waters. The Fe-to-C stoichiometry during anoxic mobilization differs from that after oxic precipitation, suggesting that up to 21% of buried OM escapes a lake-internal release-precipitation cycle, and can instead be exported downstream. Although anoxic habitats are transient and comprise relatively small volumes of water on the landscape scale, our results show that they may play a major role in structuring the reactivity and molecular composition of DOM transiting through aquatic networks and reaching the oceans.
Inferring position of motor units from high-density surface EMG
Authors: Lundsberg Jonathan , Björkman Anders , Malesevic Nebojsa , Antfolk Christian
Published: February 2024

The spatial distribution of muscle fibre activity is of interest in guiding therapy and assessing recovery of motor function following injuries of the peripheral or central nervous system. This paper presents a new method for stable estimation of motor unit territory centres from high-density surface electromyography (HDsEMG). This completely automatic process applies principal component compression and a rotatable Gaussian surface fit to motor unit action potential (MUAP) distributions to map the spatial distribution of motor unit activity. Each estimated position corresponds to the signal centre of the motor unit territory. Two subjects were used to test the method on forearm muscles, using two different approaches. With the first dataset, motor units were identified by decomposition of intramuscular EMG and the centre position of each motor unit territory was estimated from synchronized HDsEMG data. These positions were compared to the positions of the intramuscular fine wire electrodes with depth measured using ultrasound. With the second dataset, decomposition and motor unit localization was done directly on HDsEMG data, during specific muscle contractions. From the first dataset, the mean estimated depth of the motor unit centres were 8.7, 11.6, and 9.1 mm, with standard deviations 0.5, 0.1, and 1.3 mm, and the respective depths of the fine wire electrodes were 8.4, 15.8, and 9.1 mm. The second dataset generated distinct spatial distributions of motor unit activity which were used to identify the regions of different muscles of the forearm, in a 3-dimensional and projected 2-dimensional view. In conclusion, a method is presented which estimates motor unit centre positions from HDsEMG. The study demonstrates the shifting spatial distribution of muscle fibre activity between different efforts, which could be used to assess individual muscles on a motor unit level.
Calcitriol promotes M2 polarization of tumor-associated macrophages in 4T1 mouse mammary gland cancer via the induction of proinflammatory cytokines
Authors: Stachowicz-Suhs Martyna , Łabędź Natalia , Anisiewicz Artur , Banach Joanna , Kłopotowska Dagmara , Milczarek Magdalena , Piotrowska Aleksandra , Dzięgiel Piotr , Maciejczyk Adam , Matkowski Rafał , Wietrzyk Joanna
Published: February 2024

Our research found that vitamin D3 (VD3) treatment increased lung metastasis in mice with 4T1 murine breast cancer (BC). This study aims to investigate the impact of VD3 on the activation of tumor-associated macrophages (TAMs) in BC. Mice bearing 4T1, E0771, 67NR BC cells, and healthy mice, were fed diets with varying VD3 contents (100—deficient, 1000—normal, and 5000 IU/kg—elevated). Some mice in the 1000 and 100 IU/kg groups received calcitriol. We studied bone metastasis and characterized TAMs and bone marrow-derived macrophages (BMDMs). 4T1 cells had higher bone metastasis potential in the 5000 IU/kg and calcitriol groups. In the same mice, an elevated tumor osteopontin level and M2 polarization of TAMs (MHCIIlow CD44high phenotype) were observed. Gene expression analysis confirmed M2 polarization of 4T1 (but not 67NR) TAMs and BMDMs, particularly in the 100 IU + cal group (increased Mrc1, Il23, and Il6). This polarization was likely due to COX-2/PGE2 induction in 4T1 calcitriol-treated cells, leading to increased proinflammatory cytokines like IL-6 and IL-23. Future studies will explore COX-2/PGE2 as a primary mediator of calcitriol-stimulated inflammation in the BC microenvironment, especially relevant for BC patients with VD3 deficiency and supplementation.
Widespread and increasing near-bottom hypoxia in the coastal ocean off the United States Pacific Northwest
Authors: Barth John A. , Pierce Stephen D. , Carter Brendan R. , Chan Francis , Erofeev Anatoli Y. , Fisher Jennifer L. , Feely Richard A. , Jacobson Kym C. , Keller Aimee A. , Morgan Cheryl A. , Pohl John E. , Rasmuson Leif K. , Simon Victor
Published: February 2024

The 2021 summer upwelling season off the United States Pacific Northwest coast was unusually strong leading to widespread near-bottom, low-oxygen waters. During summer 2021, an unprecedented number of ship- and underwater glider-based measurements of dissolved oxygen were made in this region. Near-bottom hypoxia, that is dissolved oxygen less than 61 µmol kg−1and harmful to marine animals, was observed over nearly half of the continental shelf inshore of the 200-m isobath, covering 15,500 square kilometers. A mid-shelf ribbon with near-bottom, dissolved oxygen less than 50 µmol kg−1extended for 450 km off north-central Oregon and Washington. Spatial patterns in near-bottom oxygen are related to the continental shelf width and other features of the region. Maps of near-bottom oxygen since 1950 show a consistent trend toward lower oxygen levels over time. The fraction of near-bottom water inshore of the 200-m isobath that is hypoxic on average during the summer upwelling season increases over time from nearly absent (2%) in 1950–1980, to 24% in 2009–2018, compared with 56% during the anomalously strong upwelling conditions in 2021. Widespread and increasing near-bottom hypoxia is consistent with increased upwelling-favorable wind forcing under climate change.
Intra-articular injection of ascorbic acid enhances microfracture-mediated cartilage repair
Authors: Chen Zhian , Zhang Sihe , Duan Peiya , Yin Zhengbo , Dong Shuangbin , Pang Rongqing , Tan Hongbo
Published: February 2024

Previous studies have confirmed that ascorbic acid (AA) can promote cartilage repair and improve cartilage differentiation in bone marrow mesenchymal stem cells. However, the use of microfracture (MFX) combined with AA to repair cartilage damage has not been studied. This study established a rabbit animal model and treated cartilage injury with different concentrations of AA combined with MFX. Macroscopic observations, histological analysis, immunohistochemical analysis and reverse transcription quantitative polymerase chain reaction analysis of TGF-β, AKT/Nrf2, and VEGF mRNA expression were performed. The results showed that intra-articular injection of AA had a positive effect on cartilage repair mediated by microfractures. Moreover, 10 mg/ml AA was the most effective at promoting cartilage repair mediated by microfractures. Intra-articular injection of AA promoted the synthesis of type II collagen and the formation of glycosaminoglycans by downregulating the mRNA expression of TGF-β and VEGF. In summary, this study confirmed that AA could promote cartilage repair after MFX surgery.
Unraveling the mechanism of tip-enhanced molecular energy transfer
Authors: Coane Colin V. , Romanelli Marco , Dall’Osto Giulia , Di Felice Rosa , Corni Stefano
Published: February 2024

Electronic Energy Transfer (EET) between chromophores is fundamental in many natural light-harvesting complexes, serving as a critical step for solar energy funneling in photosynthetic plants and bacteria. The complicated role of the environment in mediating this process in natural architectures has been addressed by recent scanning tunneling microscope experiments involving EET between two molecules supported on a solid substrate. These measurements demonstrated that EET in such conditions has peculiar features, such as a steep dependence on the donor-acceptor distance, reminiscent of a short-range mechanism more than of a Förster-like process. By using state of the art hybrid ab initio/electromagnetic modeling, here we provide a comprehensive theoretical analysis of tip-enhanced EET. In particular, we show that this process can be understood as a complex interplay of electromagnetic-based molecular plasmonic processes, whose result may effectively mimic short range effects. Therefore, the established identification of an exponential decay with Dexter-like effects does not hold for tip-enhanced EET, and accurate electromagnetic modeling is needed to identify the EET mechanism.
A model for secondary traumatic stress following workplace exposure to traumatic material in analytical staff
Authors: Woodhams Jessica , Duran Fazeelat
Published: February 2024

Analytical professionals working in criminal justice and in social media companies are exposed to aversive details of traumatic events. Albeit indirect, exposure in these roles is repeated and can be extreme, including exposure to material containing lethal violence, sexual assault, and serious self-harm, leading to post-traumatic stress disorder and Secondary Traumatic Stress reactions. Incorporating relevant empirical research, this article considers the mechanisms that may contribute to post-exposure post-traumatic stress disorder and Secondary Traumatic Stress reactions in these roles. Building on the Ehlers and Clark model, subsequent extensions, and the authors’ experience of working as, and conducting research with, law enforcement professionals, a new model is proposed to explain post-exposure post-traumatic stress disorder/Secondary Traumatic Stress reactions.