bluuebunny/crossref_metadata_2025 huggingface dataset:
Liposomal co-permeation assay reveals unexpected membrane interactions of commonly prescribed drugs
Authors: Odehnalová Klára , Balouch Martin , Storchmannová Kateřina , Zadražil Aleš , Berka Karel , Štěpánek František
Published: July 2023

The permeation of small molecules across biological membranes is a crucial process that lies at the essence of life. Permeation is involved not only in the maintenance of homeostasis at the cell level but also in the absorption and biodistribution of pharmacologically active substances throughout the human body. Membranes are formed by phospholipid bilayers that represent an energy barrier for the permeating molecules. Crossing this energy barrier is assumed to be a singular event, and permeation has traditionally been described as a 1st order kinetic process, proportional only to the concentration gradient of the permeating substance. For a given membrane composition, permeability was believed to be a unary property dependent only on the permeating molecule itself. We provide experimental evidence that this long-held view might not be entirely correct. Liposomes were used in co-permeation experiments with a fluorescent probe, where simultaneous permeation of two substances occurred over a single phospholipid bilayer. Using an assay of six commonly prescribed drugs, we have found that the presence of a co-permeant can either enhance or suppress the permeation rate of the probe molecule, often more than two-fold in each direction. This can have significant consequences for the pharmacokinetics and bioavailability of commonly prescribed drugs when used in combination and provide new insight into so-far unexplained drug-drug interactions, as well as changing the perspective on how new drug candidates are evaluated and tested.
Biogeochemistry concepts in medicine: Radiosensitizing pancreatic cancer through pathology driven biosynthesis of gold nanoparticles.
Authors: Schwartz-Duval Aaron , Mackeyev Yuri , Gagea MIhai , Krishnan Sunil , Sokolov Konstantin
Published: July 2023

An effective strategy for overcoming radiotherapy resistance is to sequester radiosensitizing hafnium oxide or gold nanoparticles (GNPs) within tumors, but desmoplasia, but desmoplasia creates a delivery barrier impeding this approach. Here we report a radiosensitization strategy that overcomes this limitation by applying an atomic-scale agent - ionic gold - for in situ biosynthesis of GNPs within tumors. We showed that the in situ generation of GNPs occurs with higher efficiency in cancerous pancreatic cells than in non-cancerous cells and that these GNPs have high nuclear localization, resulting in the specific radiosensitization of cancer cells. Our studies in a xenograft murine model of pancreatic cancer revealed a uniform distribution of GNPs in the tumor, with insignificant gold content and low toxicity in normal organs. Radiosensitization by biosynthesized GNPs halted tumor growth for more than 30 days and was associated with a significantly higher median survival versus radiation alone (235 vs 102 days, respectively).
Development of a Rapid Adeno-Associated Virus (AAV) Identity Testing Platform through Comprehensive Mass Analysis of Full-length AAV Capsid Proteins
Authors: Smith Josh , Guapo Felipe , Strasser Lisa , Millan-Martin Silvia , Milian Steven , Snyder Richard , Bones Jonathan
Published: July 2023

Adeno-associated viruses (AAVs) are commonly used as vectors for the delivery of gene therapy targets. Characterization of AAV capsid proteins (VPs) and their post-translational modifications (PTMs) has become a critical attribute monitored to evaluate product quality. To accommodate the growing use of AAV delivery systems, rapid analytical methods that comply with good manufacturing practice (GMP) standards are needed. As shown in previous studies, mass protein liquid chromatography-mass spectrometry (LC-MS) analysis of full-length AAV VPs provides both quick and reliable serotype identification as well as proteoform information of each VP. However, for AAV2, separation of VP2 and VP1 has proven difficult to obtain, with successful separation only achieved when using mobile phase modifiers incompatible with MS. This incompatibility hinders in-depth AAV VP characterization by suppressing ion signal, thus reducing VP proteoform identifications through the generation of low intensity MS spectra. Using AAV2 as a test case, we demonstrate how coupling hydrophilic interaction liquid chromatography (HILIC) with MS compatible difluoroacetic acid (DFA) as a mobile phase modifier, achieves complete separation of the three AAV VPs while also generating high quality MS spectra. Employing increased MS resolving power enabled improved identification of VP proteoforms whose PTMs were confirmed using peptide mapping. The LC-MS workflow was further transformed to develop an assay using GMP compliant software capable of rapid AAV serotype profiling. Incorporated into this method is the ability to perform serotype PTM characterization if desired. Such a platform provides product quality control capabilities that are easily accessible within a regulatory setting.
Total Synthesis of Sclerotioloid A
Authors: Siitonen Juha
Published: July 2023

A four-step total synthesis of a structurally unique N-propargyllated 2,5-diketopiperazine alkaloid sclerotioloid A has been achieved. Structural studies point towards sclerotioloid A being a helically chiral racemate in the solid state.
Oxidative coupling of biogas to ethylene over a trilobe-shaped Mn-Na2WO4/α-Al2O3 catalyst in a single-pellet reactor
Authors: L'HOSPITAL Valentin , Guillemot Jordan , Beucher Rémi , Michon Thomas , Bonnet Didier , Schuurman Yves , Farrusseng David
Published: July 2023

The oxidative coupling of methane (OCM), which offers a direct route for converting methane into higher-value ethylene. Despite the development of selective catalyst formulations, kinetic and reactor design studies have been hampered by a lack of data for truly isothermal, relevant. Because of exothermicity issues, the temperature of a fixed-bed reactor filled with Mn-Na2WO4/SiO2 catalysts show a sudden temperature run-away accompanied with a drastic loss of selectivity. The objective of this study is to measure catalyst activity under relevant reaction conditions of pressure (3 bar), biogas composition (no dilution) and contact time, while keeping the process as isothermal as possible. To this aim, we have synthesized and shaped a trilobed Mn-Na2WO4/α-Al2O3 catalyst, which may be used as is at industrial scale, and measured its performance in a single-pellet reactor. We found that the presence of CO2 does not degrade catalyst performance, even on long run, which should enable the use of a CO2-rich stream such as biogas. Actually, higher methane conversions have been obtained in the presence of CO2, likely due to a possible contribution of methane dry reforming reaction. We also noticed a slow catalyst activation over the first 100 hours while selectivity was kept constant.
Neurodermatitis in Baquba City, Diyala Governorate/Iraq Clinical and histopathological study
Authors:   Baquba Teaching Hospital, Diyala , Iraq, Khalil Ibrahim Gibran , Yahya abbood Sarmad , D Hameed Saad
Published: July 2023

Background: Many patients that have itchy thickened skin lesions are lichenified, it's located on the extremities namely on the knees, feet, dorsum of the hands, and /or elbows was being seen bilaterally and may be symmetrically. Objective: To evaluate clinical and histopathological features of neurodermatitis with some similarities to psoriasis in Iraqi patients. Patients and Methods: Twenty- Five patients with neurodermatitis attending Department of Dermatology, Baquba Teaching Hospital were enrolled in this study in time between 1st January 2020 to 31th January 2021. All patients were being examined and full history was taken, including age of the patients, onset and duration of the disease, severity and type of itching. A full examination was done to identify the character, colour, shape, site, and involvement of other body site of lesion. Incisional biopsy specimens from both lesion and adjacent normal skin were obtained from 9 patients and submitted to histological assessment. Results: Ten of the patients (40%) were male and fifteen (60%) were females, their age ranged from 29-70 years, with a mean of 49.5 years. The average duration ranged from one month- 15 years with median 7.5 years. Clinically; patients have severe itchy plaques that distributed bilaterally like those of psoriasis, involvement of the knees (56%), dorsum of the both hands, feet, and elbows, also having ( lichenification ,that is characterized by thickening of the skin and exaggeration of the skin lines ) which characteristic of the individual lesion of lichen simplex chronicus, these plaques were symmetrical, well defined, sharper, more keratotic, violaceous pigmentation, marked accentuation and thickening of skin. Psoriatic scales are not present typically on the plaques of these patients. These plaques mainly located on extremities. Nine specimens' taken for histopathologiacl findings showed hyperkeratosis, acanthosis, dermal papilomatosis, suprapapillary epidermal thinning. All patients mentioned a severe itching which was paroxysmal in typing, more severe in the evening. Conclusion: ( Lichenified psoriasis) Psoriatic neurodermatitis might be lichen simplex chronicus as a result to repetitive itching and scratching of plaque psoriasis. This was typical neurodermatitis and not psoriasis. Keywords: Psoriatic neurodrmatitis,Lichenification, Plaque psoriasis
Knowledgment of Birth Spacing Among Women Attending Primary Health Care Centers in Mukalla District, Yemen
Authors:   Department of Family medicine, College of Medicine and Health Sciences, Hadhramout University, Yemen, Saeed Abaddan Najla , Saleh Sayad Asrar , I Alezzi Jalil
Published: July 2023

Background: Short birth spacing linked with adversative health consequences for infant, child and maternal mortality also increases the chances of mother and their children survival. Objective: To assess the determinants and the knowledge of birth space amongst women of reproductive age in Mukalla district, Hadhramout Governorate, Yemen. Patients and Methods: A cross sectional study of 384 women of multiplicative ages (15-49 years) was conducted at primary health care centres in Mukalla district. The study was conducted from November. 2018 to Oct 2019. Results: The median birth spacing was 35 months. (50.8 %) of respondents have been committed undersized birth spacing underneath the indorsed interval of ideal delivery spacing. Multivariate logestic V regression revealed that age of mother between 15-24 years (OR 3.255, 95%CI 1.598-6.629, P=0.001), not enough family income (OR 1.867, 95%CI1.104-3.158, P =0.020 ), number of living children ≤ 3 children (OR 1.225, 95%CI .532–2.520, P=0.027) and breast feeding duration < 6 months (OR7.435 , 95%CI 1.490 – 37.101,P=0.014) or 6-<12 months (OR 7.320, 95%CI 1.406–38.116, P=0.018) were linked with augmented hazard of short birth spacing, whereas mother’s history of chronic disease (OR.026,95%CI .003-.227,P=.001) and modern family planning methods utilization (OR.208, 95%CI.112-.386, P=0.000) were linked with decreased risk of little birth space. (58.1%) of respondents had high level of knowledge about the birth spacing. Conclusion: Certain factors were significant predictors of short birth spacing in Mukalla's women. This should lead to encouragement of longer birth spacing between births. Keywords: Birth spacing; knowledgment; primary health care centers; Yemen
Reciprocal regulation between the molecular clock and kidney injury
Authors: Rey-Serra Carlos , Tituaña Jessica , Lin Terry , Herrero J Ignacio , Miguel Verónica , Barbas Coral , Meseguer Anna , Ramos Ricardo , Chaix Amandine , Panda Satchidananda , Lamas Santiago
Published: July 2023

Tubulointerstitial fibrosis is the common pathological substrate for many etiologies leading to chronic kidney disease. Although perturbations in the circadian rhythm have been associated with renal disease, the role of the molecular clock in the pathogenesis of fibrosis remains incompletely understood. We investigated the relationship between the molecular clock and renal damage in experimental models of injury and fibrosis (unilateral ureteral obstruction, folic acid, and adenine nephrotoxicity), using genetically modified mice with selective deficiencies of the clock componentsBmal1,Clock, andCry. We found that the molecular clock pathway was enriched in damaged tubular epithelial cells with marked metabolic alterations. In human tubular epithelial cells, TGFβ significantly altered the expression of clock components. AlthoughClockplayed a role in the macrophage-mediated inflammatory response, the combined absence ofCry1andCry2was critical for the recruitment of neutrophils, correlating with a worsening of fibrosis and with a major shift in the expression of metabolism-related genes. These results support that renal damage disrupts the kidney peripheral molecular clock, which in turn promotes metabolic derangement linked to inflammatory and fibrotic responses.
The Diagnostic Value of Fecal Fusobacterium nucleatum Combined with FIT and CA199 in the Diagnosis of Colorectal Cancer
Authors: Jia Tianhong , Yu Yang , Wang Yan , Li Ming , Liu Shuzhuo , Li Wei
Published: July 2023

Objective: To analyze the diagnostic value of fecal Fusobacterium nucleatum detection, fecal immunochemical test (FIT), and carbohydrate antigen 19-9 (CA19-9) detection for colorectal cancer (CRC). Method: A total of 78 CRC patients and 60 healthy individuals were enrolled in this study. Stool and blood samples were collected for the 3 diagnoses, and ROC curves were analyzed for diagnostic value. Result: The 3 diagnoses’ positive detection rates in CRC samples were significantly higher than those of healthy samples (P < 0.05). The combined CRC diagnoses showed significantly higher sensitivity as compared to individual fecal F. nucleatum detection (χ2 = 6.495, P = 0.011), FIT (χ2 = 4.871, P = 0.027), and serum CA19-9 detection (χ2 = 7.371, P = 0.007). The area under the ROC curve for fecal F. nucleatum detection was 0.63 [95% confidence interval (CI) = 1.124–6.238], with a sensitivity of 73.08% and specificity of 85.00%, whereas FIT was 0.65 (95% CI = 1.365–9.241), with a sensitivity of 51.28% and specificity of 96.67%, meanwhile, serum CA19-9 detection was 0.62 (95% CI = 1.517–12.342), with a sensitivity of 69.23% and specificity of 98.33%. The combined CRC diagnoses showed an area under the ROC curve of 0.76 (95% CI = 1.213–6.254), with a sensitivity of 87.18% and specificity of 70.00%. Conclusion: The combined diagnoses of fecal F. nucleatum detection, FIT, and serum CA19-9 detection can significantly improve the sensitivity and accuracy of CRC diagnosis, which has high clinical application value to provide guidance for clinical CRC screening and early intervention treatment.
Chinese Female Return Migrants’ Emotion in the Domestic Sphere
Authors: Zhang Yinan
Published: July 2023

Recently, the study of emotion has become an important subject in sociology. Many works have been done on analyzing people’s emotions and emotion work, especially on migrants and transnational families, how people feel when they are apart from their families, and how they try to manage their feelings. However, not many studies have been done of the emotions and emotion work of return migrants and their relationship with their family members. Therefore, in this paper, the emotion work of female return migrants and their relationship with their family members is studied. In this thesis, the feelings experienced and how they manage their feelings will be examined, and the consequences and impact of their effort in trying to manage their feelings will be discussed. In most cases, female return migrants may face more severe challenges than males for many reasons such as social stereotypes of women and roles they should take on in a family, and the emotions they are supposed to feel. Hence, it is noteworthy to study how they deal with these issues.
CRITERIOS DE VALOR DE MARCA CENTRADO DESDE UNA PERSPECTIVA DEL CONSUMIDOR
Authors:   UNIVERSIDAD CATOLICA DE SANTA MARIA, AREQUIPA-PERU, DE LA CRUZ MENDOZA FERNANDO ARON , TALLEDO MONROY BRUNELLA ,   UNIVERSIDAD CATOLICA DE SANTA MARIA, AREQUIPA-PERU
Published: July 2023

La presente investigación tiene por objeto plantear factores y dimensiones de medición para la construcción de valor de marca, considerando la perspectiva del consumidor. El estudio de valor de marca fue aplicado al centro de estudios superiores de formación tecnológica TECSUP, usando la técnica del cuestionario usando el modelo de Aaker, y la escala de Likert, se aplicó a 159 estudiantes del programa de estudios de Gestión y Mantenimiento de Maquinaria Pesada e Industrial, se puede medir a través de la percepción del consumidor, evaluando conjunto de impresiones, pensamientos e inclusive emociones que puede tener un individuo con relación a una marca buscando generar una alta satisfacción. Para ello se hace una explicación sobre la importancia del consumidor y la influencia del marketing. En esta investigación se realizó la misma bajo el enfoque de una metodología de análisis documental, elaborados por diversos autores relevantes para el estudio con participación de la experiencia propia del autor como gestor en el mercado local y sur. Considerando que el compromiso del consumidor es un concepto relativamente nuevo pero de creciente importancia a la hora de generar valor. Palabras clave: Valor de marca, consumidor, marketing
ANTITUMOR ACTIVITY OF SOME PYRIDINECARBOXY ACID COMPOUNDS IN TUMOR CELL CULTURES
Authors: A.A. Epishkina , O.N. Deryabina , D.S. Blinov , O.N. Tumutolova , E.V. Blinova , E.A. Kutorkina , V.A. Pakina
Published: July 2023

We studied the antitumor activity of two compounds - derivatives of pyridinecarboxylic acids with laboratory codes LHT-13-19 and LHT-17-19 in two cancer cell cultures: colon HT29 and estrogen-sensitive breast cancer MCF-7. Сompounds were synthesized in the department of chemistry, technology of synthetic drugs and analytical control of VNС BAV (Russia). A possible mechanism for the development of secondary chemoresistance was determined on the organoid model of triple-negative breast cancer, provided to us by scientists from the FGBI “N.N. Dmitry Rogachev" of the Ministry of Health of Russia. Both compounds were shown to be cytotoxic against two human neoplasias with an inhibitory concentration of 1.3 × 10-7 for substance LHT-17-19 and LHT-13-19 – 7.6 × 10-3 M for colon cancer HT29 and 1.6×10-5 (LHT-17-19) and 3.8×1 (LHT-13-19) for MCF-7 breast cancer. During the formation of secondary resistance of triple-negative breast cancer cells to LHT-13-19, the reverse transport of compound molecules is activated, as evidenced by the increase in the concentration of the substance in the cultivation medium after washing the three-dimensional culture. Under the same experimental conditions, although secondary resistance to LHT-17-19 is formed, no efflux of molecules into the medium is observed, which indicates that in this case other mechanisms not related to reverse transport may be involved.
THE FIRST RESULTS OF THE PROGRAM-TARGET PLANNING OF THE DEVELOPMENT OF THE REHABILITATION SERVICE IN THE ASTRAKHAN REGION
Authors: D.O. Ermolaev , Yu.N. Ermolaeva , G.S. Khazova
Published: July 2023

The relevance of the study is the effectiveness of program-target planning lies in the fact that this process is one of the main instruments of state policy in Russia, including in the field of healthcare. The aim of the study - to analyze the effectiveness of the regional program and develop proposals for the further development of rehabilitation services in the Astrakhan region. Materials and methods – the object of the study is the main indicator indicators of the regional program "Optimal medical rehabilitation for health restoration (Astrakhan region)" (hereinafter referred to as the Program) for the period from 2022-2030, namely, the share of cases of medical care for medical rehabilitation at the expense of CHI funds separately in inpatient and outpatient settings, as well as the share of medical rehabilitation departments, equipped with modern medical rehabilitation equipment, in comparison with the planned indicators for 2022. Results and discussion – the fulfillment of the plan task in the conditions of a round-the–clock hospital in 2022 in the subject amounted to 106.9%, in the conditions of a day hospital – 94.8% (on average 100.9%), which indicates that the first indicator indicator of the Program was exceeded. Planned indicators in outpatient settings were fulfilled in 2022 by only 58.4%. The reason for non-fulfillment of planned volumes was: 1) insufficient number of outpatient departments of medical rehabilitation; 2) the work of outpatient departments during an incomplete calendar year. In the subject in 2022, two departments of medical rehabilitation out of 5 planned until 2025 (i.e., in fact - 40%) are equipped with modern rehabilitation equipment, which indicates the implementation of the third indicator indicator of the Program. Conclusion - the obtained research data indicate the average effectiveness of the considered regional program.
Neoplasias del cuello en pediatría: actuación en su manejo quirúrgico
Authors: Morocho Constante Mónica Priscila , Morales Changoluisa Mishell Katherine , Jimbo Naspud Fabiola Estefania , Escobar Andrade Paola Mireya
Published: July 2023

Las neoplasias o tumoraciones en el cuello constituyen un problema frecuente en niños que son llevados al servicio de urgencias. La mayoría de este tipo de tumores son benignos. Con relación al tratamiento, es importante destacar que, dado el avance de las otras modalidades terapéuticas como la quimioterapia y radioterapia, la cirugía se ha convertido en un elemento más del armamento terapéutico de estas patologías, no obstante, en ciertos tumores, la extirpación quirúrgica sigue siendo imprescindible. En virtud de lo expuesto es que se define el objetivo de la presente investigación, el cual consiste en plasmar las generalidades del manejo quirúrgico de las neoplasias más frecuentes del cuello en la población pediátrica. La investigación se realizó bajo una metodología de tipo documental bibliográfica, bajo la modalidad de revisión. El tratamiento quirúrgico, en muchos casos, es complementario a otros tratamientos, como la radioterapia y la quimioterapia, sin embargo, existen casos en que es fundamental. La técnica quirúrgica empleada depende de la localización, tamaño y características de la neoplasia. En última instancia, el objetivo del manejo quirúrgico es lograr la extirpación completa del tumor mientras se preservan las estructuras vitales y se optimizan los resultados funcionales para los pacientes pediátricos con neoplasias de cuello. La cirugía, además de emplearse con fines de extirpar este tipo de neoplasias, se realizan para la obtención de muestras de biopsia, para introducir un catéter venoso central o dispositivo de acceso venoso y para aliviar algunas situaciones de urgencia. Con base en la revisión se encontró que los tumores quirúrgicos más frecuentes del cuello en pacientes pediátricos son los tiroideos. Asimismo, otro cáncer quirúrgico que se presenta con frecuencia son las adenopatías.
КОМПЛЕКСЫ НИКЕЛЯ(II) И КОБАЛЬТА(III) С ОСНОВАНИЕМ ШИФФА НА ОСНОВЕ 4-БЕНЗОИЛ-3-МЕТИЛ-1-ФЕНИЛПИРАЗОЛ-5-ОНА
Authors: Гусев А.Н. , Балуда Ю.И. , Шульгин В.Ф. , Кискин М.А. , Крюкова М.А.
Published: July 2023

Синтезированы и исследованы методом РСА координационные соединения кобальта и никеля с азометиновым лигандом – продуктом конденсации 4-бензоил-3-метил-1-фенилпиразол-5-она и 2-аминофенола. Установлено, что ионы Со(II) в условиях реакции окисляются до Co(III) и образуют комплексы состава (Et3NH)[CoL2]×2H2O, в то время как ионы Ni(II) формируют соединение (Et3NH)(H3L)[NiL(HL)]×H2O×Solv. Анионная часть комплекса никеля представляет собой супрамолекулярный димер [Ni(L)(HL)]22-, сборка которого осуществляется посредством водородных связей. Комплексы изучены методом статической магнитной восприимчивости. Установлен диамагнетизм соединения Со, что подтверждает его окисление и свидетельствует о низкоспиновом состоянии иона металла. Обнаружены слабые ферромагнитные взаимодействия ионов Ni(II) через мостиковые водородные связи.
PEMBENTUKAN KARAKTER PADA ANAK USIA DINI DI LINGKUNGAN KELUARGA
Authors: Nindiya Devi Candra , Indrawati Dwi , Setyowati Rina Insani , Prawinda Raras Ayu
Published: July 2023

Character formation in early childhood is a necessity that must be done by parents as family leaders. Because all parents want their children to have good character in life. This descriptive qualitative research with literature study discusses the formation of character in early childhood in the family environment. The data analysis technique uses content analysis by sorting out data according to the research objectives. This paper produces several things as follows. First, the role of parents or family in character building for early childhood, among others: parents must be role models for children, parents must be able to show empathy for children, parents must use good moments to build children's character, parents can tell stories and life, parents must be able to show pride in children, parents must be able to teach children to control themselves, and parents must give children opportunities to practice character actions. Second, tips for parents or families to form early childhood with good character, including consistent, continuous, and consistent, because children are influenced by the environment, temperament, and character. Third, the program that can be offered to families to build character for early childhood is parenting. The types of programs include family gatherings, foundation classes, seminars, consultation days, field trips, home activities, cooking on the spot, bazaar day, mini zoo, and home education videos
Characterizing Circular Supply Chain Practices in Industry 5.0 With Respect to Sustainable Manufacturing Operations
Authors: Sami Abdul , Manzoor Umair , Irfan Asmara , Sarwar Farhan
Published: July 2023

The current research investigated the significance of circular supply chain practices in Industry 5.0 with respect to their sustainable manufacturing operations. Through a comprehensive review of the literature, the current study identified key circular supply chain practices and their potential benefits for Industry 5.0. The findings indicated that closed-loop supply chains, sustainable sourcing, product design for circularity, and waste reduction may assist Industry 5.0 firms to achieve their sustainability objectives while enhancing the operational efficiency. Moreover, the study also highlighted the challenges associated with the implementation of circular supply chain practices including the necessity for collaboration among supply chain partners, investment in new technologies and infrastructure, and the development of new skills and capabilities. From a practical and managerial perspective, the implications suggest that firms aiming to adopt circular supply chain practices in Industry 5.0 should prioritize collaboration and coordination, make investments in new technologies and infrastructure, and foster the acquisition of new skills and capabilities. To complement this research, future studies could employ empirical research methods in order to validate the findings and recommendations as well as explore potential barriers to the implementation of circular supply chain practices in Industry 5.0.
More Than A Game: Extended Reality in Critical Care Nursing
Authors: Justice Stephanie , Sullivan Kelly
Published: July 2023

The need for innovation in hospital education is significant. Extended reality presents a unique opportunity to provide education on the unit during working hours with a minimal cost. The varitey of extended reality hardware and software is rapidly evolving. This commentary addresses the options for critical care education in XR.
IMPACT OF THE EXPRESSIVE ART THERAPY METHOD ON THE FEELING OF FEAR
Authors: Gülriz AKAROĞLU Emine , KOÇ Aysel , TEKBAŞ Ulya , ŞEN Hümeyra Nur , ERDOĞAN Şeyda Nur
Published: July 2023

Bu çalışmanın amacı 6 Şubat 2023 tarihinde meydana gelen Kahramanmaraş merkezli depremden etkilenen farklı yaş grubundaki depremzede katılımcıların insan ilişkilerini geliştirme ve sosyalleşmelerini sağlamak amacıyla dışavurumcu sanat
terapi yöntemiyle korku duygularını aza indirgenmesi ve çizimlerinin incelenmesi hedeflenmiştir. Verilen eğitim her bir oturumu 180 dakika süren toplamda 2 farklı grupla gerçekleştirilmiştir. 10 günlük olarak planlanan eğitim programı
depremzede ailelerin farklı KYK yurtlarına yerleştirilmesi nedeniyle 5. günde sonlandırılmıştır. Bu çalışmada yer alan ısındırma, hikâye oluşturma, korku figürlerinin çizimleri ve değerlendirme çalışmaları planlanan eğitimin 2.
günü yapılmıştır. İnsan ilişkilerini geliştirme ve sosyalleşme temelli verilen dışa vurumcu sanat yöntemindeki etkinlikler Olcay Güler ve Nur Dinçer Genç tarafından yazılan sanat terapisi kitabından birkaç etkinlik bütünleştirilerek
alınmıştır. Çalışma grubu, tesadüfi örneklem yöntemi kullanılarak Konya iline göç eden yaşları 6-15 arası değişen 40 gönüllü katılımcı ile gerçekleştirilmiştir. Araştırmada veri toplama aracı olarak araştırmacılar tarafından hazırlanan
yarı yapılandırılmış görüşme formu kullanılmıştır. Verileri çözümlemek için içerik analizi yöntemi kullanılmıştır. Sonuçlara göre insan ilişkilerini geliştirme ve sosyalleşme temelli eğitim öncesinde depremzede katılımcıların %91,67’sinin
korkularını herhangi bir kişiyle paylaşmadığı, gergin, genellikle mutsuz ve iletişime kapalı oldukları saptanmıştır. Eğitim sırasında yaşanılan korkuyu en fazla %61,11 oran ile kalplerinde hissettikleri, yaşadıkları deprem korkusunu
resimlerinde %38,89’’u çizmişken %61,11’i resmetmediği, çizim aşamasında %8,33’ü resimde belirtilen sınırın dışına çıkarken %91,67’sinin ise sınır dışına çıkmadığı, %41,67’sinin korkularının üzerine giderek yendiği, korktukları
zaman ise en fazla oranla 58,33’ünün korkularından kaçtığı ve korku figürlerini komikleştirme sürecinde 36 katılımcıdan %66,67’si komik figür resmetmişken %33,33’ü resmine komik figür çizimi yapmadığı sonuçlarına ulaşılmıştır.
Eğitim sonunda daha önce duygularını ve korkularını paylaşmayan katılımcıların duygu ve korkularını paylaştığı, kendilerini daha rahat hissettiklerini, kurdukları cümleler ile iletişime açık hale geldikleri ve korkularının azaldığını,
daha az korktuklarını ya da korktukları zaman korkularının komik hallerini hatırlayarak korkmayacaklarına dair geri dönütler alınmıştır.
A TRAVELER IN 19TH CENTURY GIOVANNI BOTTESINI
Authors: SABUNCU Irmak
Published: July 2023

24 Aralık 1821’de, İtalya’nın kuzeyinde, Lobardy bölgesinde, Crema’da doğan müzisyen, sekiz kardeşin altıncısı olarak dünyaya geldi. Müziğe ilk adimi amcası sayesinde olmuş, ilk keman derslerini Crema Katedral Orkestrasının başkemancısı
ve yöneticisi olan amcası Carlo Cogliati’den almiştir. 1835’te girdiği Milan Konservatuvarında öğrenimi suresince kontrbas derslerini Luigi Rossi’den alırken, Piantanida, P. Ray ve F.Basili ve Nicola Vaccai’den piyano, teori ve
kompozisyon dersleri almış 1839 yılında mezun olmuştur. İtalyan Operası’nın bütün dünyada kendini hissettirdiği 19’ncu yüzyılda, “Bel Canto” üslubuyla kontrbas çalıcılığını birleştiren virtüoz, bunu başta Avrupa’nın onde gelen
müzik başkentlerinin yanı sıra, Rusya, Iskandinavya, Amerika ve Osmanlı coğrafyasında adından saygıyla söz ettirmiş, müzik tarihinde iz bırakmıştır. Donizetti ve Bellini üslubunu devam ettiren bir besteci olarak Verdi geleneğine
yakınlığıyla Wagner üslubuna karşıt bir yerde durur. Bununla beraber muzikal üslubu, doneminin gelmiş geçmiş en olağanüstü kontrbas virtüözü olarak, kontrbas için besteleri günümüz kontrbas öğretisinde eşsiz yerini korumaktadır.
A GENERAL EVALUATION ON THE HABITS AND BEHAVIOR PATTERNS IN THE TRADITIONAL TURKISH KITCHEN CULTURE
Authors: DİKEN Hasan Ali
Published: July 2023

Bilindiği üzere, insanlar, geleneksel eksenlerdeki yaşamsal sahaları dâhilinde; mutfak kültürüne büyük bir önem yüklemişlerdir. Bu durumun akabinde, insanların, geleneksel mutfak kültürüne dönük bir çerçeve içerisinde; birtakım alışkanlıklar
ve davranışlar kazandıklarını ifade etmekte yarar vardır. Malum alışkanlık ve davranış kalıpları aracılığıyla da zamanla yemek kültürüne dair yerel, ulusal ve evrensel özelliklerin ortaya çıkma sürecine girilmiştir. Bahse konu
alışkanlık ve davranış örüntüleri; bilhassa toplumdan topluma değişiklik, farklılık ve çeşitlilik göstermiştir. Bu durumun bir devamı olarak, insanlar arasında cereyan eden mutfak alışkanlıkları ve davranışları; “sofra düzeni”,
sofra adabı”, “yeme-içme usulü”, “ikram şekli” ve benzeri biçimlerde gelişmeler sergilemiştir. Geleneksel mutfak kültürü, esas itibarıyla; kültürlerin ve medeniyetlerin, kendilerine özgü birer çizgi kapsamında ortaya koydukları
alışkanlıkların ve davranışların yansımalarını içermektedir. Söz konusu minvalde, Türkler de dünya kültür ve medeniyet tarihine yönelik geleneksel mutfak alışkanlıklarına ve davranışlarına başlıca katkılar sunmuşlardır. İlgili
durum, müstakil bir geleneksel Türk mutfak kültürünün yaratılma ve yaşatılma seyrini öne çıkarmıştır. Zira Türk mutfağındaki alışkanlık ve davranış örüntülerinin, belli bir hiyerarşiye dayandırılmak suretiyle icra edilmesi, bahse
konu durumu özetlemektedir. Bu bağlamda, geleneksel Türk mutfağına paralel olarak vuku bulan bir kısım alışkanlıklar ve davranışlar, zaman içinde Türk toplumuna has karakteristik niteliklere bürünüp; gelenek haline gelen bir yeme-içme
silsilesine vesile olmuştur. Bahsedilen gelenek unsurları, ekseriyetle Türk sofra adabının önemli parçaları arasında yer almışlardır. Bu parçalar, belli bir bütünlük arz etmek kaydıyla, Türklerin yeme-içme kültürlerindeki temel
kodları meydana getirmişlerdir. Malum ifadelerin ışığında, bu çalışma bünyesinde, geleneksel Türk mutfağına zamanla dâhil edilen temel kültürel kodları teşekkül ettiren belli başlı alışkanlık ve davranış faktörlerine yer ayrılarak;
bu faktörler üzerine genel bir değerlendirmede bulunulacaktır. Dolayısıyla da Türk halk mutfağının genelleşen ve gelenekselleşen yönleri ön plana çıkarılmaya çalışılacaktır.
EVALUATION OF PHYSICAL EDUCATION AND SPORTS TEACHERS' OPINIONS ON IN-SERVICE TRAINING PROGRAMS
Authors: EŞİYOK Sedat , ALINCAK Fikret
Published: July 2023

Toplumların ilerleyebilmesi ve gelişim sağlayabilmesi için insanların belirli hedef ve amaçlar doğrultusunda yetiştirilmesi gerekmektedir. Gerek bilimde gerekse de teknolojide yaşanan gelişmeleri eğitim ortamınıda etkilediği görülmektedir.
Öğretmenlerin lisans eğitiminde almış oldukları bilgilerin belli bir zamandan sonra geçerliliğini yitirdiği veya etkisinin azaldığı belirtilmektedir. Bu sebeple öğretmenlerin gelişen teknolojiye adapte olması için mesleki anlamda
bir takım hizmet içi eğitimlere ihtiyacı olmaktadır. Bundan dolayı Milli Eğitim Bakanlığı yılın belli dönemlerinde öğretmenlerin gelişimine yarar sunmak amacı ile hizmet içi eğitim programları gerçekleştirmektedir. Bu çalışma,
beden eğitimi ve spor öğretmenlerinin hizmetiçi eğitim programlarına ilişkin görüşlerini değerlendirmek amacıyla yapılan bir çalışmadır. Araştırmanın çalışma grubunda Gaziantep İlinde görev yapmakta olan 40 beden eğitimi ve spor
öğretmeni ile ve gönüllülük esasına uygun olarak yüz yüze görüşme tekniği kullanılmıştır. Araştırmada nitel araştırma yöntemlerinden olan mülakat yöntemi kullanılarak, elde edilen veriler, içerik analizi yöntemi ile çözümlenmiştir.
Araştırma sonucunda; beden eğitimi öğretmeni ve spor öğretmenleri hizmet içi eğitim programının; mesleki ve kişisel gelişimi için yararlı bir program olduğu, kendilerini yenilemesini sağlayan program ve yeni bilgiler kazandıran
bir program olduğunu ve dolayısıyla gerekli bulduklarını belirtmişlerdir. Araştırmaya katılan beden eğitimi ve spor öğretmenlerinin hizmet içi eğitim programı sürecinde; eğitim veren kişilerin yetersiz olmasından dolayı, tarihlerinin
uygun olmaması ve on-line eğitimde internete ulaşım konusundan dolayı sorun yaşadıkları görülürken, hizmet içi eğitim programının öğretmenlerin daha aktif olmasını sağladığı, öğretmenlere yeni bakış açısı kazandırdığı, eğitimin
nitelikli olmasına imkân sağladığı görülmüştür. Bunun yanında katılımcılar genel anlamda hizmet içi eğitim programını yeterli görürken, daha etkili olabileceiğini, yapılan eğitimin alan bazında ya da ihtiyaç duyulan alanlarda verilmesi
gerektiğini ifade etmişlerdir. Ayrıca beden eğitimi ve spor öğretmenleri hizmet içi eğitim programının süresinin genel anlamda yeterli olduğunu, eğitimlerin yaz tatilinde olması ve ara tatillerde olması gerektiği ifade edilmiştir.
Çalışmaya katılan öğretmenlerin; hizmet içi eğitim programını alanında uzman kişilerin ve akademisyenlerin vermesi gerektiği ön plana çıkarken, on-line yapılan eğitim programlarının uygun olmadığı ve yüz yüze olması gerektiği sonucuna
ulaşılmıştır.
SIGNS OF CRISIS IN THE GLOBAL ECONOMY
Authors: HARUNOĞULLARI Erdal
Published: July 2023

The ongoing COVID-19 pandemic's economic effects, geopolitical unrest, natural disasters, and social unrest have caused the global economy to face unprecedented difficulties and uncertainties. Numerous indicators point to the potential
for a global recession or even depression, which could have catastrophic effects on millions of people. The US dollar and US consumer spending are two significant components of the global economy that are examined in this article.
It examines how the COVID-19 pandemic's effects on consumer spending and the dollar's strength have affected world trade, growth, inflation, and financial stability. Additionally, it discusses a few possible regional and national
policy responses to these problems. The article provides a thorough and critical overview of these subjects by utilizing theoretical insights and empirical data from various sources. It aims to inform and captivate readers who
are curious about the state and prospects of the global economy today.
INVESTIGATION OF THE RELATIONSHIP BETWEEN THE STRESS LEVEL AND LIFE SATISFACTION OF VISUALLY IMPAIRED INDIVIDUALS DURING COVID-19 PANDEMIA PROCESS
Authors: KELEŞ Emre , ALTAY Birsen
Published: July 2023

Bu çalışma, görme engelli bireylerin Covid-19 pandemisi sürecinde yaşamış olduğu stres düzeyleri ile yaşam doyumları arasındaki ilişkinin incelenmesi amacıyla planlandı. Tanımlayıcı türdeki bu araştırmanın evrenini Kasım- Aralık 2020
tarihleri arasında Çorum Altınokta Körler Derneği’ne kayıtlı görme engel olan bireyler oluşturmaktadır. Örneklem seçimine gidilmeden evreninin tamamına ulaşılması hedeflenmiştir. Çalışma 62 görme engelli bireyin katılımıyla tamamlanmıştır.
Verilerin toplanmasında Kişisel Özellikler Bilgi Formu, Yaşam Doyumu Ölçeği ve Algılanan Stres Ölçeği kullanılmıştır. Katılımcıların %79’u erkek, %74,2’ si evli ve %40’ı ortaokul-lise eğitim seviyesine sahiptir. Görme engelli bireylerin
Algılanan Stres Ölçeğinden aldıkları puan ortalaması 26,42±8,20 ve Yaşam Doyum Ölçeğinden aldıkları puan ortalaması ise 13,29±3,66 olarak bulunmuştur. Cinsiyet, eğitim durumu, ekonomik durum algısı, genel sağlık algısı, Covid-19
geçirme durumu ve anksiyete- kaygı yaşama durumu ile Algılanan Stres Ölçeği puan ortalamaları arasında istatistiksel olarak anlamlı bir farklılık vardır (p<0,05). Ekonomik durum algısı ve Covid-19 geçirme durumu ile Yaşam Doyum
Ölçeği puan ortalamaları arasında istatistiksel olarak anlamlı bir farklılık vardır (p<0,05). Görme engelli bireylerin stres algılarının ve yaşam doyumlarının orta düzeyde olduğu belirlenmiştir. Covid-19 pandemisinin görme engellilerin
stres düzeyleri ve yaşam doyumları üzerine etkilerinin daha net bir şekilde ortaya konulabilmesi için daha geniş örneklem grupları ile benzer çalışmalar yapılabilir.
SAINTHOOD IN CHRISTIAN CHURCHES
Authors: MAHMUTOĞLU Muhammet
Published: July 2023

Диндерде ыйык инсандарга ишенимдин орду өзгөчө. Анткени ыйман ээлери ыйык инсандардын өз өмүрүн динге арнаган деп баалашат; динди туура жашап, жайылтып, элге үйрөтүп, керек болсо бул максатта жанын да курмандыкка чалаарына ишенишет.
Ошол эле учурда ыйык инсандардын мындай каармандыгына суктанган жана таасирленген динчилдер аларды ар дайым урматтап, алардай болууга жана жашоого аракет кылышат. Ыйык инсандарга багытталган ашыкча урмат-сый көбүнчө аларды жогорку
улуу күчтөр сыяктуу кабылдануусуна себеп болгон. Инсан сезимине тийиштүү бул көрүнүштү диндер түрдүүчө маанилендирген. Динге кызмат кылгандарга баа берип, аларга өзгөчө даража ыйгарган диндердин бирөөсү-христиан дини. Бул дин тарых
бою өз мүчөлөрүнүн арасынан ишенимине бек, адеп-ахлактык жашоосу жана дин үчүн кылган аракеттери менен алдыга суурулуп чыккан кээ бир инсандарга ыйыктык мартабасын ыйгарган. Ошондой эле алар үчүн майрам күндөрүн белгилеп, аларга
дуба кылуу жана алардан жардам суроого уруксат берген. Бирок, христиан чиркөөлөрүнүн көбү ыйык инсандар ишенимин кабыл алышканы менен, кээ бир чиркөө мүчөлөрү башкача ишеним жана ойлорго ээ. Мындайча айтканда, христиан дүйнөсүндөгү
айырмачылыктар көптөгөн маселелерде түрдүүлүктү жараткан. Ошондой эле ыйык инсандар ишениминде дагы айырмачылыктарды пайда кылган. Мына ошол негизде христиан дининдеги ыйык инсан ишенимин чиркөөлөрдүн көз карашын эске алып изилдөөнү
максат кылдык. Мындай маанилүү маселени талдоонун аталган динди терең үйрөнүүдө салымы чоң экендигин белгилегибиз келди. Алгач ыйык инсанга байланыштуу тирминдерди ачып берүүгө жана аларга карата жасалган аныктамаларды тактоого
аракет кылдык. Андан кийин православ, католик жана протестант чиркөөлөрүнүн көз караш жана ишениминде ыйык инсандын ордун өзөзүнчө чагылдырып берүүгө аракет жасадык. Окшоштук жана айырмачылыктарын өзгөчө белгиледик. Изилдөөбүздө
камтылган темаларды так чагылдыруу максатында дескриптивтүү (сүрөттөп баяндоо) ыкмасына артыкчылык бердик. Ошого жараша фактыларга, окуяларга объективдүү мамиле жасоого аракет кылдык. Алгач изилдөөбүзгө байланыштуу булактарды жана
малыматтарды тактап, анан керектүү анализдерди жасадык.
FOREIGN TRADE COMPANIES' CURRENCY MANAGEMENT: EXAMPLE OF THE TRC3 REGION'S
Authors: ÇATUK Cüneyt
Published: July 2023

The purpose of this research is to examine how foreign trade companies in the provinces of Mardin, Sirnak, Siirt, and Batman (TRC3 region) are protecting themselves from foreign exchange risk.A survey of 275 foreign trade companies
operating in the TRC3 area was carried out in order to analyze the strategies employed by businesses to protect themselves against exchange rate risk. Multiple linear regression and Pearson correlation analyses were performed on
the survey items.The findings lead to the conclusion that 14.1% of the companies operating in the TRC3 region are unable to take any action to protect themselves against exchange rate risk, while 39% can be protected by internal
business measures, 33.9% receive assistance from banks or other financial institutions, and 5.7% gain from consulting firms.According to the findings of the study, enterprises do not take adequate measures to hedge against exchange
rate risk. Additionally, it is discovered that companies employ derivatives less to protect themselves against currency rate risk. In addition to that enterprises should be more cautious about future currency rate shocks and engage
in more derivative trades.
Pola Dakwah Pengelola Nasi Kebuli Al-Khalid Cabang Ngamprah
Authors: Raihan Azhar  , Rodliyah Khuza’i
Published: July 2023

Abstract. Da'wah is a very urgent activity. The goal in Islamic teachings is to make people have high faith, worship, and morals. Of course, da'wah can be applied anywhere, including in culinary business activities. This study aims to determine the process of da'wah, implementation of da'wah patterns and to know the impact of applying da'wah through a culinary business approach.This study uses qualitative research methods that are used to examine the condition of natural objects by using the case study method.The object of research in this study is the Manager and Consumer of the Nasi Kebuli Al-Khalid Restaurant. Dai uses the bil oral method, bil wisdom and bil kitabah as the delivery of da'wah material to employees, drivers ojol The impact conveyed, the owner and employees put their faith in God who provides sustenance. In addition, employees can maintain the company's name, increase faith and instill good morals. The work ethic shown is a reflection of the work concept which is the elaboration of aqidah, that the work is carried out with the aim of only hoping for the pleasure of Allah SWT. 

Abstrak. Dakwah merupakan aktivitas yang sangat urgen. Tujuannya dalam  ajaran Islam untuk membuat manusia memiliki akidah, ibadah, serta akhlak yang tinggi. Tentunya dakwah bisa diterapkan dimana saja, termasuk di kegiatan bisnis kuliner.  Penelitian ini bertujuan untuk mengetahui proses dakwah, implementasi pola-pola dakwah serta mengetahui dampak penerapan dakwah melalui pendekatan bisnis kuliner. Penelitian ini menggunakan metode penelitian kualitatif yang digunakan untuk meneliti pada kondisi objek yang alamiah dengan menggunakan metode studi kasus.Objek Penelitian dalam penelitian ini Pengelola dan Konsumen dari Rumah Makan Nasi Kebuli Al-Khalid. Dai menggunakan metode bil lisan, bil hikmah dan bil kitabah sebagai penyampaian materi dakwah kepada karyawan, driver ojol dan konsumen. Dampak yang disampaikan, owner dan karyawannya menaruh keyakinan kepada  Allah yang memberikan rezeki. Serta, karyawan bisa menjaga nama perusahaan, menaikan keimanan dan tertanamnya akhlak baik. Etos kerja yang diperlihatkan menjadi cerminan dari konsep kerja yang merupakan penjabran aqidah, bahwa kerja dilakukan tujuannya hanya mengharap ridho Allah SWT.
Pengaruh Video Dakwah pada Akun Tiktok @Faizinaufal terhadap Kesadaran Followers
Authors: Nabiila Setiawan  , Muhammad Fauzi Arif
Published: July 2023

Abstract: Video da'wah is a facility for sending and receiving information. Messages received by individuals or communities are in the form of content related to da'wah which aims to invite individuals or communities to continue to do good and lead a life in accordance with Islamic law. This research is related to da'wah videos on the Tiktok account @faizinaufal. The purpose and benefits of this research are to find out the da'wah material or content that is on the Tiktok @faizinaufal account, and to find out its effect.The research method used is a quantitative method using data collection techniques: questionnaires, documentation, observation and interviews. Data analysis techniques used are validation test, reliability test, descriptive statistics, simple linear regression test, F test, T test, regression model of the coefficient of determination and normality assumption test and heteroscedasticity test. The results of the research on followers illustrate that based on the output of the analysis, the R-Square value of the regression model shows that followers' religious awareness is influenced by the dakwah video of the Tiktok account @faizinaufal.

Abstrak: Video dakwah merupakan sebuah fasilitas untuk mengirim dan menerima informasi. Pesan yang diterima oleh individu atau masyarakat berupa konten-konten yang berkaitan dengan dakwah yang bertujuan mengajak individu atau masyarakat untuk terus melakukan kebaikan dan menjalankan kehidupan sesuai dengan syariat Islam. Adapun penelitian ini berkaitan dengan video dakwah pada akun Tiktok @faizinaufal. Tujuan dan manfaat penelitian ini adalah untuk mengetahui materi-materi atau konten dakwah yang ada pada akun Tiktok @faizinaufal, dan untuk mengetahui pengaruhnya. Metode penelitian yang digunakan adalah metode kuantitatif menggunakan teknik pengumpulan data: kuesioner, dokumentasi, observasi dan wawancara. Teknik analisa data yang digunakan adalah uji validasi, uji reabilitas, statistic deskriptif, uji regresi linier sederhana, uji F, uji T, model regresi koefisien determinasi dan uji asumsi normalitas dan uji heteroskedasitas. Hasil penelitian terhadap followers menggambarkan bahwa diperoleh berdasarkan output analisisnya, nilai R-Square dari model regresi yang menunjukan bahwa kesadaran beragama followers di pengaruhi oleh video dakwah akun Tiktok @faizinaufal.