bluuebunny/crossref_metadata_2025 huggingface dataset:
Visfatin (NAMPT) expression in human placenta cells in normal and pathological conditions and its hormonal regulation in trophoblast JEG-3 cells
Authors: Dawid Monika , Kurowska Patrycja , Pawlicki Piotr , Kotula–Balak Małgorzata , Milewicz Tomasz , Dupont Joelle , Rak Agnieszka
Published: September 2024

Visfatin is an adipokine involved in energy metabolism, insulin resistance, inflammation, and female reproduction. Due to limited data about its action in the human placenta, the aims of our studies included the analysis of visfatin expression and immunolocalization in trophoblast cell lines JEG-3 and BeWo as well as in human placentas from normal and pathological pregnancies. Moreover, we also checked the hormonal regulation of visfatin levels and the molecular mechanism of observed changes in JEG-3 cells. Cell culture and placental fragments collection along with statistical analysis were performed using standard laboratory procedures also described in our previous papers. We demonstrated an increased gene and protein expression of visfatin in JEG-3, BeWo cells, while variable expression in maternal and fetal parts of normal/ pathological pregnancy placentas. In addition, the immunolocalization of visfatin was observed in the cytoplasm of both cell lines, the capillary epithelium of the maternal part and syncytiotrophoblasts of the placental fetal part; in all tested pathologies, the signal was also detected in decidual cells. Furthermore, we demonstrated that hormones: progesterone, estradiol, human chorionic gonadotropin, and insulin increased the visfatin levels in JEG-3 cells with the involvement of specific signaling pathways. Taken together, differences in the expression and localization of visfatin between normal and pathological placentas suggested that visfatin may be a potential marker for the diagnosis of pregnancy disorders. In addition, we found that placental levels of visfatin can be regulated by hormones known to modulate the function of placental cells.
Suggested guidelines in reporting results from mediation analysis, standardized or unstandardized?
Authors: Abrar Mohammad Nahian Ferdous , Zhang Hongmei , Jiang Yu
Published: September 2024

Mediation analysis is commonly implemented in psychological, epidemiological, and social behavior studies to identify potential factors that mediate associations between exposures and physical or psychological outcomes. Various analytical tools are available to perform mediation analyses, among which Mplus is widely used due to its user-friendly interface. In practice, sumptuous results provided by Mplus, such as the estimated standardized and unstandardized effect sizes, can be difficult for researchers to choose to match their studies. Through a comprehensive review and utilizing findings from a proven study, we proposed guidelines and recommendations to help users select between standardized or unstandardized results based on data attributes and users’ hypotheses. We also provided guidelines to choose from several types of standardized values based on the types of variables, including exposures, mediators, and outcomes.
Spatial distribution characteristics and influencing factors of tourism resources based on point of interest data
Authors: Ding Feng , Zhang Shijun , Dai Luote
Published: September 2024

The agglomeration and dispersion of tourist attractions in space greatly affect the development of regional tourism resources and the consumption choice of tourism market. At present, the research on the spatial distribution characteristics of tourist attractions and their influencing factors mainly adopts induction and investigation, and there is a lack of effective statistical models for the research on the spatial distribution of tourist attractions and their influencing factors in some historical and cultural ancient cities. This paper uses Internet technology to obtain the spatial distribution data of tourist attractions in Shaoxing city, and uses mean nearest neighbor analysis, nuclear density analysis, imbalance index analysis, standard deviation ellipse and other spatial statistical analysis techniques and geographical detector methods to study the spatial distribution characteristics and influencing factors of tourist attractions in Shaoxing City. This paper studied the distribution characteristics of tourist attractions in Shaoxing city, such as spatial aggregation, distribution equilibrium and spatial orientation, and applied geographical detector to study the influencing factors of the spatial distribution of scenic spots. It was concluded that the spatial distribution pattern of scenic spots was affected by various factors such as natural environment, social environment and economic environment. The explanatory power of two-factor interaction is obviously stronger than that of single factor. The research results provide scientific basis for the planning, layout and development of tourist attractions in Shaoxing and its similar cities, and then promote the high-quality development of tourism in Shaoxing and its similar historical and cultural ancient cities.
Press funding and strategies in online and offline business: The Portuguese case
Authors: Faustino Paulo , Martins Carla
Published: September 2024

Media managers are facing a variety of profound and disruptive challenges generated by the impact of digitization and platformization on the production, distribution and consumption of media goods. Interestingly, platforms provide users with the opportunity to become providers of information (‘produsers’). The technological ecology requires publishing organizations to constantly rethink and adjust their competitive strategies and business models to achieve financial sustainability. Based on interviews with media industry players, this article intends to understand Portuguese newspaper companies’ funding models, business challenges in a pre-pandemic period, and how managers were reacting and adapting their practices. This study has found that the companies demonstrated the predominant implementation of management practices aimed at exploring mixed revenue sources – that is, through the traditional activity of selling advertising and newspapers and the support of paper and the sale of digital advertising content. Companies where the main source of revenue came from a mixed-model ended up, for the most part, investing more, or having more participation, in digital, with a few exceptions.
Efecto de ácido naftalenacético, ácido indol-3-butírico y ácido indol-3-acético en la respuesta rizogénica in vitro de Neltuma alba
Authors: Carloni Edgardo , Rodriguez Milena Nahir , Verga Anibal , Grunberg Karina
Published: September 2024

Neltuma alba, conocido como “algarrobo blanco”, es una especie nativa importante en la ecorregión región del Chaco y especialmente en Argentina debido a su valor biológico, productivo y cultural. La sobreexplotación maderera está generando una pérdida de la diversidad genética de la especie. La propagación vegetativa in vitro se presenta como una herramienta biotecnológica para la conservación de los recursos genéticos forestales. El objetivo de este estudio fue evaluar los efectos de diferentes tipos y concentraciones de auxinas en la respuesta rizogénica in vitro de N. alba. Los resultados indican que los explantes tienen capacidad para desarrollar raíces adventicias con o sin la presencia de fitorreguladores, aunque concentraciones mayores de auxinas, inducen una mejor respuesta rizogénica. El subcultivo de los explantes en un medio sin auxinas, después de 7 días de exposición a 4 mg/l de IBA, ha demostrado reducir la formación de callos y minimizar las malformaciones en las raíces. Esta metodología de trabajo permite alcanzar una tasa de sobrevivencia del 75% de las plantas ex vitro.
Proposal for formulation of blocks to guarantee the sustainability of buildings in the Abidjan real estate park
Authors: Mamery Adama Sérifou , Ovo Sandrine Flora Augou , Ouaga Jean Bruce Nataniel Gboga , Edjikémé Emeruwa
Published: September 2024

A recurring fall of buildings in recent years (2013-2023) in the city of Abidjan has caused enormous material and human damage. This study was initiated in order to propose a formulation for the development of concrete blocks to guarantee the sustainability of buildings in the Abidjan real estate. The raw materials used are aggregates composed of sand, granite powder and a hydraulic binder (portland cement) then water for mixing. The aggregates were characterized before being used for the manufacture of the various FSB, FPS and FPG concrete blocks. The materials were subjected to physical and mechanical tests. The results showed that the sand and granite powder aggregates have a granular class of 0/1 and 0/2 respectively. Concerning concrete blocks, the density increases with the maturation time, namely 28 days maximum and when they are composed of both sand and granite powder (FPS). This significantly reduces the number of pores in the material. The compressive strength test showed that at 28 days of maturation, the FPS are more resistant than the FPG and FSB with respective values of 6.50 MPa; 5.31 MPa and 3.10 MPa. It appears that the addition of granite powder to the composition of the concrete blocks improves the density, porosity and compressive strength of the latter. The promotion of this formulation among concrete block manufacturers would make it possible to improve real estate construction, guarantee the durability of buildings in the Abidjan real estate park and thus avoid the possible fall of buildings.
Revolutionizing plant breeding: a historical perspective from cross-pollination to gene editing
Authors: T Ugandhar , E Komala. , Prasad. S Shyam , D Sammaiah. , Singh. M Ghan , M Narender , N Gandhi
Published: September 2024

The history of plant breeding can be broadly divided into four eras: the Pre-Mendelian era (before 1900), the Mendelian era (1900-1920), the post-Mendelian era (1921-1950), and the Modern era (after 1950). Significant milestones include the release of the first hybrid maize varieties in 1961, the first sorghum hybrid (CSH-1) in 1964, the first bajra hybrid (HB-1) in 1965, and the first pigeon pea hybrid (ICPH-8) in 1991. Achieving a world with zero hunger requires a sustainable increase in food production and distribution and elimination of poverty. This goal demands scientific, logistical, and humanitarian approaches to ensure food security from farmers and breeders to policymakers and governments.
Conventional breeding techniques alone are insufficient to meet the challenges posed by climate change, biotic and abiotic stress, and the growing global population projected to reach 10 billion by 2050. Novel plant breeding techniques, such as genome editing, speed breeding, and omics technology integration, offer precise, cost-effective, and less time-consuming solutions. These techniques enable the editing of agriculturally significant genes, promoting hybrid seed production, induced apomixis, and resistance to biotic and abiotic stress.
Genome editing technologies have evolved, with CRISPR/Cas9 and its variants, base editing (BE), and prime editing (PE) playing pivotal roles in generating transgene-free plants. These advancements have significant implications for crop improvement, meeting food and nutrition security, and catering to regional preferences. Syngenta's initiative to open rights to CRISPR-based technologies through the Shoots by Syngenta platform exemplifies the collaborative efforts needed to drive agricultural innovation and sustainability. The review discusses the current regulatory regimes governing genome-edited crops, prospects of new tools such as DNA-free editing systems and nanotechnology, and their applicability in crop improvement. A multidisciplinary approach involving political, social, economic, and scientific stakeholders is essential for the successful adoption of genome editing technologies, which will ultimately make agriculture a lucrative profession and attract youth to the field.
ADAT PENUNDAAN PERNIKAHAN AKIBAT MENINGGALNYA SALAH SATU ANGGOTA KELUARGA: Studi Kasus di Desa Ngumpul, Kabupaten Jombang
Authors: Hidayat Firman
Published: September 2024

Marriage in Islam is very strong agreement to obey the commands of Allah and follow the Sunnah of the Messengerand implement them is worship. In Islamic law on the prohibition of marriage are related to time, ie the prohibitionto perform a wedding when someone does ihram, ihram both Hajj and Umrah Ihram and the prescribed period.Most of the villagers Ngumpul District of Jogoroto Jombang, still holding on to habits that have been passeddown through generations of the less well to do weddings, ie do delay marriage when one family member died andhad to wait until the turn of the year for the death of one of the members the family. They believe if there is a breakwill get a negative impact on later life. Authors of this study looked significantly related to how a customimplementation delays due to the wedding of a family member dies, the factors that cause the still-compliancewith the customary delay marriage and how the traditional view of Islamic law to delay the wedding.[Pernikahan menurut Islam adalah akad yang sangat kuat untuk mentaati perintah Allah SWT sertamengikuti sunnah Rasul dan melaksanakannya adalah ibadah. Dalam hukum Islam terdapat tentanglarangan pernikahan yang berkaitan dengan waktu, yaitu larangan untuk melakukan pernikahanketika seseorang melakukan ihram, baik ihram haji maupun ihram umrah dan pada masa iddah.Sebagian masyarakat Desa Ngumpul Kecamatan Jogoroto Kabupaten Jombang, masih berpegangpada kebiasaan yang sudah turun-temurun terhadap hari yang kurang baik untuk melakukan acarapernikahan, yaitu melakukan penundaan pernikahan ketika salah satu anggota keluarganya meninggaldunia dan harus menunggu sampai pergantian tahun atas kematian salah satu anggota keluargatersebut. Mereka meyakini apabila ada yang melanggarnya akan mendapatkan dampak negatifterhadap kehidupannya kelak. Penyusun memandang penelitian ini signifikan terkait bagaimanapelaksanaan adat penundaan pernikahan akibat meninggal salah satu anggota keluarga, faktor-faktoryang menyebabkan masih dipatuhinya adat penundaan pernikahan serta bagaimana pandangan hukumIslam terhadap adat penundaan pernikahan tersebut.]
Požehnání v biblické a prakticko-teologické perspektivě: Příspěvek k diskuzi o žehnání párů stejného pohlaví
Authors: Landová Tabita
Published: September 2024

The study examines the concept and practice of blessing in contemporary Christian churches and reflects on the possibilities of blessing same-sex couples. It emphasises the need to distinguish the blessing of a same-sex couple from the legal act of entering into a civil
partnership. The purpose of the blessing is not to affirm or sanctify a particular life form but to bring a couple committed to an enduring relationship of love, respect and fidelity before God, promising his favour, grace and gifts. The study consists of three parts. First, it
introduces the concept of blessing in the Old and New Testament. The second part discusses blessing from a contemporary practical theological perspective. It presents blessing as a gift and a task of the church community and as a key motif of casual services. It points to the specific linguistic form of blessing as opposed to prayer, wish and proclamation, presents blessing as an act of communication and reflects on the question of its content and effects. The third part deals with the question of who or what can be blessed and whether it is
theologically legitimate to bless same-sex couples. It reflects on the possibility of blessing in the pastoral practice of the Roman Catholic Church, anchored in the declaration Fiducia supplicans, and in the liturgical practice of the Evangelical Church of Czech Brethren. It concludes with a summary of the findings.
Obřad křtu podle Agendy české z r. 1581
Authors: Chalupski Michal
Published: September 2024

Agenda česká [Czech Agenda] is a still under-researched source of the reformed liturgy in the Bohemian lands. It represents a liturgy influenced by Lutheran theology. This article argues that the form of the baptismal ceremony is based on the Wittenberg church order,
published in 1539, and shows how the editors used their German source: Their approach was to some extent creative. There appear various changes compared to the original: Some parts take a different position; the exorcism is only optional and there is no mention of the handing over of the baptismal robes. The baptism itself is performed by a threefold pouring, not by immersion. The Agenda česká follows Martin Luther’s example in simplifying the baptismal liturgy and in this respect goes beyond its source. However, this trend was not common in the whole Bohemian and Moravian milieu, influenced by the German reformation. Thus, the Agenda česká represents only one of several streams.
Advanced Rai Stage in Patients with Chronic Lymphocytic Leukaemia Correlates with Simultaneous Hypermethylation of Plural Tumour Suppressor Genes
Authors: Forsterová Kristina , Votavová H. , Schwarz J. , Karban J. , Štuka Č. , Trněný M.
Published: September 2024

Hypermethylation of CpG islands within gene promoters is one of various mechanisms of gene silencing involved in the pathogenesis of human cancer. By using methylation-specific polymerase chain reaction we explored aberrant promoter methylation of five tumour suppressor genes in 29 patients with chronic lymphocytic leukaemia. Aberrant methylation of DLC1, SHP1, p15 and p16 occurred, respectively, in 89.7 %, 70 %, 62.1 % and 31 % of patients at diagnosis. Lamin A/C was unmethylated in all the samples. Hypermethylation of at least one gene was detected in 96.6 % of patients. Concurrent methylation of two or more genes correlated with Rai stage at diagnosis.
Gene Regulation by BCL3 in a Cervical Cancer Cell Line
Authors: Maldonado V. , Espinosa M. , Pruefer F. , Patiño N. , Ceballos-Cancino G. , Urzua U. , Juretic N. , Melendez-Zajgla Jorge
Published: September 2024

BCL3 is a putative proto-oncogene deregulated in haematopoieitic and solid tumours. It has been suggested that its oncogenic effects could be mediated, at least in part, by inducing proliferation and inhibiting cell death. To provide more insight into the mediators of these effects, we used an unbiased approach to analyse the mRNA expression changes after knocking-down BCL3 using specific shRNAs. One hundred eighty genes were up-regulated and sixtynine genes were down-regulated after knocking down BCL3. Function analyses showed enrichment in genes associated with cellular growth and proliferation, cell death and gene expression. We found that STAT3, an important oncogene in human cancer, was the central node of one of the most significant networks. We validated STAT3 as a bona fide target of BCL3 by additional interference RNA and in silico analyses of previously reported lymphoma patients.
The Assessment of Array Comparative Genomic Hybridization in Complex Karyotype Analyses
Authors: Bystřická Dagmar , Zemanová Z. , Březinová J. , Gančarčíková M. , Grosová L. , Šárová I. , Izáková S. , Berková A. , Michalová K.
Published: September 2024

Molecular-cytogenetic methods were used to analyse and specify complex genome rearrangements in malignant cells. Twelve samples of bone marrow cells were collected from patients with myelodysplastic syndromes (MDS). The complex karyotypes were examined by multicolour fluorescence in situ hybridization (mFISH), high-resolution multicolour banding (mBAND) and array comparative genomic hybridization (aCGH). For aCGH, DNA was isolated from fixed bone marrow cells in methanol and acetic acid and amplified by whole-genome amplification. Three samples were analysed by the oligonucleotide array NimbleGen on the basis of full service. BAC-based Haematochips (BlueGnome) were used for the other nine samples. Sensitivity and detection limits of both methods were compared. The results obtained by mFISH/mBAND were in most cases confirmed by the microarray technique. aCGH detected 43 unbalanced chromosomal changes that were also identified by classical cytogenetics and FISH. Moreover, aCGH discovered 14 additional changes. Cryptic amplifications and deletions were characterized with a resolution of 0.5 Mb. In one bone marrow sample with suspected monosomy 5 detected by conventional cytogenetic analysis, aCGH revealed a 22.3 Mb region of chromosome 5 inserted in another autosome within the complex karyotype. Amplified DNA was successfully used for aCGH in 11 out of 12 cases, improving resolution of unbalanced chromosomal aberrations. The combination of both approaches brought more detailed description of complex karyotypes and is highly recommended.
Irresolution and Other Weaknesses of Soul in Descartes
Authors: Homan Matthew
Published: September 2024

This paper contributes to a better understanding of Cartesian irresolution by clarifying its relation to akrasia and wantonness. It argues that irresolution (qua passion) is the same as neither akrasia nor wantonness, but is, like them, a kind of weakness of soul. If akrasia consists in having what Descartes calls ‘firm and decisive judgments’ (F&D judgments) but failing to act on them, and wantonness consists in not having any F&D judgments at all, but acting completely at the behest of the passions, then irresolution can be understood as a state between akrasia and wantonness: the irresolute lacks F&D judgments (like the wanton) but (unlike the wanton) actively strives to attain them.
Rasmussen invariants of Whitehead doubles and other satellites
Authors: Lewark Lukas , Zibrowius Claudius
Published: September 2024

We prove formulae for the

F
2

\mathbb{F}_{2}

-Rasmussen invariant of satellite knots of patterns with wrapping number 2, using the multicurve technology for Khovanov and Bar-Natan homology developed by Kotelskiy, Watson, and the second author.
A new concordance homomorphism, which is independent of the Rasmussen invariant, plays a central role in these formulae.
We also explore whether similar formulae hold for the Ozsváth–Szabó invariant 𝜏.
Considerations of Post-Pandemic Life
Authors: Ulmer Jasmine B. , Salvo James M.
Published: September 2024

Although the duration of a pandemic has a limit, it is also a time wherein we comport ourselves toward a world where there is a pandemic. Pandemic time can be a time of panic, during which we may attempt to find solace in the comforting objectivity of the sciences. However much science is necessary, we should remember that science is not the only relevant discourse. Further, adjacent to the particulate matter that spreads airborne contagions, pandemic time can be a time of minuscule identity, the forgetting of our collective being when we are overwhelmed by a concern for personal survival. During a pandemic time, without a collaborative approach to scholarship in general, we can become stuck in pandemic time and isolated as precisely calculating beings that survive only to reproduce iterative knowledge and maintain existing routines.
Evaluation of microstructure and mechanical properties of Al1050/Al2O3/Gr composite processed by forming operation ECAP
Authors: Hassan Alhassan Mohammed , Gattmah Jabbar , Shihab Suha K.
Published: September 2024

Enhancement of microstructure and mechanical features of the hybrid aluminum matrix composite (HAMC) prepared by the stir-casting process (SCP) is quite significant for failure prevention during the service. In this work, the circular rod of hybrid aluminum matrix composite reinforced with particles of alumina (Al2O3) 50 μm, and graphite (Gr) 40–100 µm fabricated by SCP was adopted. This Al1050/Al2O3/Gr composite was subjected to severe plastic deformation using equal channel angular pressing (ECAP) at room temperature to show the impact of this process on the microstructure and mechanical features of the fabricated composite. Grain refinement, strength, and hardness were evaluated at different forming passes (1P, 3P, and 5P) with two channel angles (die angles) of 120° and 135°. The results revealed that the number of ECAP cycles has a significant effect on the refinement of the grain size. The fifth pass of ECAP (5P ECAP) with a die angle of 120° gave more refinement of the grains in the range of 36–75 nm compared to other passes. On the other hand, the strength and hardness relatively augment until 5P ECAP with increasing the cycle number at two die angles of 120° and 135°. The ultrafine grain can reduce the voids of the aluminum matrix then the hardness is enhanced.
Uncovering the coronavirus outbreak: present understanding and future research paths
Authors: Roy Jayati , Banerjee Arnab , Mukherjee Sandip , Maji Bithin K.
Published: September 2024

Introduction

The review discusses the pathophysiological mechanisms of SARS-CoV-2, the modes of transmission, and the long-term health consequences of COVID-19, emphasizing the importance of research and successful public health initiatives.

Content

COVID-19 taxonomy, pathophysiology, symptomatology, and epidemiological importance are the key objects of this research paper. This review explains how COVID-19 affects different systems of the body, including respiratory, cardiovascular, and reproductive systems of the human body. It describes the modes of entry of the virus into the cell; more precisely, ACE2 and TMPRSS2 in viral entry. In addition, the present study analyzes the situation of COVID-19 in India regarding vaccine development and the transmission rate related to socioeconomic factors.

The manifestation of COVID-19 presents a lot of symptoms and post-acute problems, issues which are seriously impacting mental health and physical health as well. The present review summarizes current research into pathogenicity and the mode of virus transmission, together with immunological responses. Coupled with strong vaccination programs, public health initiatives should hold the key to fighting this pandemic.

Outlook

Long-term effects and the development of treatment methods will need further study, as ambiguities on COVID-19 remain. Multidisciplinary collaboration across healthcare sectors in this respect is of paramount importance for the prevention of further spread and protection of public health.
Optimal design of linear and nonlinear PID controllers for speed control of an electric vehicle
Authors: Oleiwi Bashra Kadhim , Mohamed Mohamed Jasim
Published: September 2024

Electric vehicles (EVs) as a sustainable safety system are being increasingly used and receiving attention from researchers for several reasons including optimal performance, affordability for consumers, and environmental safety. EV speed control is a crucial issue that requires reliable and intelligent controllers for maintaining this matter. The primary goal of this research is to design the linear and nonlinear Proportional, Integral, and Derivative (PID) controllers to control EV speed based on the minimum value of ITAE plus ISU (integral square of control signal) as well as satisfy the constrain on response overshoot. All the proposed PID controllers, conventional PID controller, arc tan PID controller, and nonlinear PID controller (NL-PID) are used in cascade with EV model. In all these PID controllers, a filter is used with the derivative term to avoid the effect of the noise. The tuning of the proposed controller gains is achieved using Aquila Optimization algorithm. The controllers’ parameter tuning is primarily determined by reducing the Integral Time Absolute Error (ITAE) and integral square control signal. Numerical simulation, system modelling, and controller design are done using MATLAB. By comparing the results, the proposed controllers’ efficacy is demonstrated. The proposed NL-PID controller provides promising EV speed regulation control and robustness to external disturbances. Where, the performance specifications of the proposed NL-PID controller when using unit step input with step disturbance of 0.2 and −0.2, and the model parameters increased by 25% from its nominal value are the rise time is 2.608, settling time is 2.608, overshoot is 0.073%, the maximum control signal is 6.230, number of slope sign change in the control signal is 231, and ITAE is 17.6064. The comparative results show the NL-PID controller’s superior performance for tracking the reference signal with the lowest peak for the control signal, rejection of disturbances, ability to overcome model uncertainties, and lowest ITAE value.
The controller-first constraint beyond the Basic Variety: how do instructed learner varieties solve contexts of competition?
Authors: Repiso Isabel
Published: September 2024

The Basic Variety has been described as a fully fledged system that is developed in second-language acquisition. It is guided by a small number of interacting phrasal, semantic, and pragmatic constraints. This article is devoted to the semantic controller-first constraint, which says that “the NP-referent with highest control comes first” in discourse contexts where this constraint comes into conflict. The Basic Variety, as described by Klein and Perdue, relates to migrant learners that were exposed to target languages in naturalistic contexts and situations outside the classroom. Our study also deals with learners living in the target language’s country at the time of the data collection, but our learners were benefiting from foreign language teaching at university. The goal of this study is twofold. The first part of the article discusses the origins of the key notion of ‘controller’ and introduces related theoretical underpinnings, such as argument hierarchies of transitive verbs and crucial factors determining argument realization. Our analysis shows that the controller-first constraint overlaps with two key concepts of the description of L1 functional grammars – i.e., control asymmetry and the Actor-Undergoer Hierarchy – suggesting that it does not only pertain to the Basic Variety but broadly speaking to the human language capacity. The second part of this study presents some preliminary results on the L2 grammars of Spanish-speaking learners of French in a context of ‘competition’. Our results show the pervasiveness of the controller-first constraint on L2 grammars beyond initial, non-instructed learner varieties, suggesting that this semantic principle is not totally independent of (a) the specifics of the source language and (b) the target constructions of the foreign language classroom.
Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway
Authors: Long Xueyuan , Yang Yanpeng , Zhou Ke
Published: September 2024

Background

Sepsis triggers myocardial injury and dysfunction, leading to a high mortality rate in patients. Cardiomyocyte apoptosis plays a positive regulatory role in septic myocardial injury and dysfunction. However, the mechanism is unclear.

Methods

Bioinformatics analysis was used to identify differentially expressed genes in septic mice heart and validate key genes and pathways. The correlation of protein–protein and protein–pathway was analyzed. Sequentially, the cecal ligament and puncture (CLP) was used to induce septic mice, followed by Serpine1 inhibitor treatment. Finally, the regulatory relationship of Yes-associated protein1 (YAP1), Serpine1, and caspase-3 was verified in LPS-exposed mouse cardiomyocytes.

Results

Bioinformatic analysis found that Serpine1 expression is decreased in septic mice heart tissue and closely related to the HIPPO signaling pathway, while YAP1 is negatively correlated with apoptosis. In vivo, CLP induced a reduction of survival rate, cardiac dysfunction, and an increase in Serpine1 and Cleaved Caspase-3 expression, which could be reversed by a Serpine1 inhibitor. In vitro, LPS induced the mouse cardiomyocytes apoptosis, which could be reversed by Serpine1 inhibitor. Silencing YAP1 and Serpine1 reversed the LPS-induced increase in Serpine1 and Cleaved Caspase-3 expression, but silencing Serpine1 did not affect the LPS-induced YAP1 expression.

Conclusion

Sepsis induced mouse cardiomyocytes apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathway.
An environmentally greener and reusability approach for bioenergy production using Mallotus philippensis (Kamala) seed oil feedstock via phytonanotechnology
Authors: Chaudhry Bisha , Sultana Shazia , Zhang Zhiyong , Ahmad Mushtaq , Munir Mamoona , Osman Sameh M. , Akhtar Muhammad Saeed , Bokhari Awais , Cho Chungyeon , Choi Dongwhi
Published: September 2024

Mallotus philippensis, a novel and mostly unexplored feedstock with a significantly greater oil content of 50%, serves as the foundation of a prospective and sustainable supply for biodiesel synthesis. The most notable aspect of this research is the development and application of a bio-based green nanocatalyst with ingenuity and environmental safety via a method employing an autoclave reactor from raw conventional materials such as rotten fungus fruits infused with a nano-WO3 catalyst. The obtained catalyst was then subjected to several analyses, including scanning electron microscopy, energy-dispersive X-ray analysis, X-ray diffraction, and Fourier transform infrared spectroscopy. This research focused on the potential of this unique feedstock within the limits of an industrial setting. The synthesized nanocatalyst showed promising long-term performance and great catalytic efficiency. The biodiesel production reached its peak under optimal conditions, which included a methanol-to-oil ratio of 11:1, a reaction period of 120 min at 110°C, and a catalyst concentration of 0.15% by weight. Under precisely optimized conditions, this investigation rigorously examined the effectiveness, environmental stability, reusability, and economic feasibility of this green catalyst. The findings of this study demonstrate the stability and consistency of nanocatalyst performance, particularly throughout reusability cycles.
El valor de legado en dos comunidades forestales en México
Authors: Torres Rojo Juan Manuel , Guevara Sanginés Alejandro , Bray David Barton
Published: September 2024

Este estudio reconoce e identifica la existencia de un motivo de legado (ML) relacionado con la conservación de los bosques en comunidades forestales con aprovechamiento forestal. Para ello, se realizó una encuesta tipo de valoración contingente en hogares de dos comunidades forestales contrastantes. Los resultados muestran que entre el 71% y el 83% de los jefes de hogar declararon su disposición a hacer un esfuerzo altruista; de esta manera, variables como la edad, el género, los ingresos, la educación y el tipo de bosque están estrechamente relacionadas con el ML. Las variaciones de estos determinantes dependen del “vehículo de pago”. La principal diferencia entre las comunidades es que cuanto mayores son los beneficios que obtienen de los recursos forestales que poseen, mayor es la disponibilidad a heredar. Los hallazgos son importantes pues corroboran que los hogares pobres aún están dispuestos a hacer un sacrificio altruista para el disfrute forestal de las generaciones futuras.
Using instrumental variables to establish causality
Authors:   Royal Holloway, University of London, Aleksin Grigory , Becker Sascha O. ,   University of Warwick, UK
Published: September 2024

Randomized control trials are often considered the gold standard to establish causality. However, in many policy-relevant situations, these trials are not possible. Instrumental variables affect the outcome only via a specific treatment; as such, they allow for the estimation of a causal effect. However, finding valid instruments is difficult. Moreover, instrumental variables (IV) estimates recover a causal effect only for a specific part of the population. While those limitations are important, the objective of establishing causality remains; and instrumental variables are an important econometric tool to achieve this objective.
A 24-Week Combined Resistance and Balance Training Program Improves Physical Function in Older Adults: A Randomized Controlled Trial
Authors: Jiang Guiping , Tan Xiaohuan , Zou Jiling , Wu Xueping
Published: September 2024

Jiang, G, Tan, X, Zou, J, and Wu, X. A 24-week combined resistance and balance training program improves physical function in older adults: a randomized controlled trial. J Strength Cond Res XX(X): 000–000, 2024—This randomized controlled trial assessed the feasibility of older adults performing combined resistance and balance training (RBT) and compared the effects of RBT on physical function with those of resistance training (RT) alone and with no exercise training in older adults. In total, 65 community-dwelling adults aged 60–74 years were randomly assigned to an RT (n = 22), RBT (n = 22), or control (n = 21) group. The exercise intervention consisted of RT or RBT for 45 minutes, 3 times per week for 24 weeks. The control group engaged in no exercise training. The compliance rates were 93% in the RT group and 92% in the RBT group. No training-related adverse effect was observed. In the RT and RBT groups, dynamic balance (p = 0.017; p < 0.001, respectively), maximum walking speed (p = 0.014; p < 0.001), upper extremity (p = 0.013; p = 0.009) and lower extremity (p = 0.009; p < 0.001) muscle strength, and spirometry (p = 0.043; p = 0.018) were significantly improved at 24 weeks compared with the control group. Only the RBT group showed significant improvement in normal walking speed (p = 0.002). Compared with the RT group, the RBT group showed additional significant improvements in dynamic balance (p = 0.001) and lower limb muscle strength (p = 0.027). The findings of this randomized controlled trial indicated that RBT was safe and feasible for older adults. Long-term RBT had better effects than either no exercise training or RT alone on improving physical function in older adults. Compared with RT, RBT additionally benefited dynamic balance and lower limb muscle function, which are clinically important factors in preventing falls, frailty, disability, and other geriatric syndromes.
Analysis Factors Associated with Work Accidents Among House Construction Workers in Karang Ayu
Authors: Kiswanto Risa Wahyu Putri , Reswari Berlian Syiffa Ardana , Anakita Cantika Salya Manikawening , Ayesha Danish
Published: September 2024

Globally, work-related injuries are a significant public health and economic issue, with approximately 5-7% of all deaths in industrialized countries caused by work-related injuries. Each year, work accidents cause 350,000 deaths and 270 million non-fatal serious injuries. Due to its high burden of occupational hazards, the construction industry is more at risk than other industries. Compared with workers in different occupations, building construction workers are three to four times more likely to die and twice as likely to be injured than workers in other occupations. This study aims to analyze the factors associated with the incidence of work accidents among house construction workers in Karangayu, Semarang Barat. This study used descriptive qualitative methods, including observation, interviews, and questionnaires. The result of this study is that factors can cause work accidents, such as age, unsafe actions such as not using PPE properly, and worker knowledge, which leads to unsafe actions. Still, in this observation, there are driving factors behind workers' unsafe actions, one of which is the non-compliance of house construction workers in Karangayu, Semarang.
Ética y utopía: la crítica a la filosofía política de Emmanuel Levinas
Authors: De Navascués Nicolás
Published: September 2024

El problema de las utopías es central para la filosofía política quizá ya desde Platón, pero indudablemente desde Moro. En este artículo se utiliza como fuente de la que hacer manar la filosofía de Emmanuel Levinas en relación con la posibilidad de desarrollar una filosofía política de la alteridad. El problema que se plantea es si la primacía de la ética desactiva el sueño utópico político o si esta filosofía de la alteridad acerca a la justicia utópica. Primero desentrañaré la semántica del término utopía en la obra del pensador lituano, después me centraré en el significado central como ética y finalmente plantearé que la obra de Levinas es una filosofía del no-lugar.
Expresar o imposible
Authors: Rubín Álvarez Abraham
Published: September 2024

Jean-François Lyotard é un dos filósofos franceses da segunda mitade do século XX que intentou darlle unha oportunidade á elaboración dun pensamento do acontecemento a partir da súa unión co motivo da diferenza.
O punto de arranque é a consideración de que o coñecemento non pode reducir toda diferenza a identidade, ao quedar sempre marxes e restos que non se poden traducir dunha lingua a outra nin asimilar por un concepto unificador.
Lyotard apostará por tratar de prefigurar o xurdimento da novidade cun pensamento que vaia máis alá do homoxéneo. A diferenza pretenderá deixar sinalados os restos inasimilables e intraducibles, tamén os despropósitos, mentres, asemade, dá espazo e lugar a un discurso e unha comunicación aberta, aínda que desaxustada, que axude a que algo aconteza.
Edipo según Foucault: de la ceguera inconsciente a la ascesis filosófica
Authors: Ortiz Juan Emilio
Published: September 2024

El presente trabajo se enfoca en el abordaje que realiza Foucault de la tragedia Edipo Rey de Sófocles. Mi objetivo es rastrear algunas diferencias entre el análisis que el autor realiza en sus trabajos de los años 70 y el que se encuentra en sus últimos cursos. En esta última etapa, aparece una interpretación que ya no se limita a la descripción genealógica de un modo de ejercer el poder, sino que muestra las implicancias transformadoras de este reconocimiento. A través de esta torsión se hace explicita la dimensión ética del rastreo genealógico, una cuestión que se expresa en un posicionamiento más claro que distingue a la verdad del saber jurídico-discursivo. Este enfoque también revela las diversas posibilidades de desestabilización, cambio y constitución a la altura de este reconocimiento.
Duelo por la muerte de un animal no humano
Authors: Cázares Blanco Rocío
Published: September 2024

El duelo de una persona adulta por la muerte de un animal no humano suele ser percibido por quienes la rodean como ridículo, frívolo o patológico. A estas actitudes reprobatorias típicamente subyacen creencias relativas a las limitadas facultades de los animales no humanos y/o los supuestos requerimientos de una vida humana plena. Consideraré varios argumentos en contra de tales creencias y espero que eso desactive algunas de las objeciones que podrían plantearse a la siguiente tesis que quiero defender: El duelo por un animal no humano puede entenderse adecuadamente en términos de la frustración de los deseos categóricos que pierden sentido tras su muerte. Para sostener esta tesis argumentaré que las nociones de vida plena y de identidad práctica son constitutivas de las concepciones tanto de deseo categórico como de duelo.
Paisaje e iberismo en Miguel de Unamuno
Authors: Gordo Piñar Gemma
Published: September 2024

En estas páginas abordamos la importancia del paisaje dentro de la obra unamuniana y la manera en que está conectado con sus planteamientos filosóficos, culturales e identitarios. A medida que Unamuno va conociendo el paisaje y el paisanaje español y portugués, se va modificando su idea de patria, trascendiendo ésta el marco nacional en pro de una unidad mayor: la ibérica. El punto final de este proceso es el iberismo que encarnó y defendió Unamuno, un iberismo de carácter cultural y espiritual, alejado del iberismo político. Para ello nos centramos en sus principales escritos sobre el paisaje español y portugués y en su correspondencia epistolar con portugueses (citando algunas cartas hasta hoy inéditas).
APPLICATION OF GREEN CHEMISTRY PRINCIPLES FOR THE DEVELOPMENT OF SOLID COMMERCIAL FORMS OF OIL-DISPLACING COMPOSITIONS
Authors: АЛТУНИНА Л.К. , КУВШИНОВ В.А. , СТАСЬЕВА Л.А. , КУВШИНОВ И.В.
Published: September 2024

В рамках принципов “зеленой химии” использована концепция глубоких эвтектических растворителей (ГЭР) для создания твердых товарных форм нефтевытесняющих композиций. Показано, что эвтектический состав на фазовой диаграмме бинарной системы “соль аммония - карбамид” соответствует ГЭР в качестве основы твердых товарных форм нефтевытесняющей композиции с наилучшими физико-химическими и технологическими характеристиками. На основе тройной системы ГЭР “соль аммония - карбамид - вода” определены оптимальные концентрации твердых товарных форм в рабочем растворе композиции. Представлены результаты лабораторных исследований и промысловых испытаний рабочего раствора твердых товарных форм нефтевытесняющей композиции.

Within the framework of green chemistry principles, the concept of deep eutectic solvents (DES) was used to develop solid commercial forms of oil-displacing compositions. It has been shown that the eutectic composition on the phase diagram of the binary system ammonium salt - carbamide corresponds to DES as the basis of solid commercial forms of oil-displacing composition with the best physicochemical and technological characteristics. The optimal concentrations of solid commercial forms in the working solution of the composition were determined for the ternary DES system ammonium salt - carbamide - water. The results of laboratory studies and field tests of the working solution based on the solid commercial forms of the oil-displacing composition are presented.
PALEOECOLOGICAL INDICATORS OF THE CONDITIONS OF PERMAFROST DEVELOPMENT IN THE AREA OF BATAGAY RETROGRESSIVE THAW SLUMP
Authors: ЛУПАЧЕВ А.В. , ТИХОНРАВОВА Я.В. , ДАНИЛОВ П.П. , ЗАНИНА О.Г. , ЧЕПРАСОВ М.Ю. , НОВГОРОДОВ Г.П.
Published: September 2024

Изучены строение и свойства отложений крупнейшей регрессивной термоденудационной котловины Батагай. Стратиграфическая последовательность многолетнемерзлых отложений предположительно непрерывно накоплена за период среднего-позднего неоплейстоцена (~700-11 тыс. лет назад) и частично трансформирована в течение голоцена. На основе палеопочвенных, палеонтологических и геокриологических данных получены новые представления об историческом развитии почвенно-растительного покрова и позднеледниковой фауны Янского плоскогорья. Подтверждены два благоприятных климатических периода формирования почвенно-растительного покрова: первый по различным методам датирования относится к эпохам МИС 15-17 (600-700 тыс. лет) либо к эпохе МИС 7е (230-250 тыс. лет); второй более уверенно датируется эпохой МИС 5е (110-130 тыс. лет).

The morphology and properties of frozen strata were studied in the area of the largest retrogressive thermal thaw slump Batagay (Yakutia). A presumably continuous stratigraphic sequence of permafrost sediments accumulated during the Middle and Late Pleistocene (~700-11 ka) and was partially transformed during the Holocene. Based on paleopedological, paleontological, and geocryological data, new suggestions have been made regarding the historical development of the soil-vegetation cover and late glacial fauna in the Yana Plateau region. Two extensive and relatively warm climatic periods favoring the formation of developed soil-vegetation cover have been identified: the first one belongs to MIS 15-17 (600-700 ka) or (depending on the dating method) to MIS 7e (230-250 ka); the second one is more certainly dates back to MIS 5e (110-130 ka).