bluuebunny/crossref_metadata_2025 huggingface dataset:
Upgrading the ICT Regulatory Framework: Toward Accelerated and Inclusive Digital Connectivity
Authors: Serafica Ramonette , Oren Queen Cel
Published: September 2024

Across different metrics, the Philippines continues to demonstrate subpar performance in information and communications technology (ICT) compared to other members of the Association of Southeast Asian Nations and countries at the same level of development. The quality of the country’s ICT regulatory environment, composed of regulatory authority, regulatory mandate, regulatory regime, and competition model, is significantly below what is considered international best practice, consequently impeding the use of various technological solutions available to bridge the gap in digital inequality. Although significant policy changes have recently been introduced, more reforms are needed to achieve inclusive and accelerated digital connectivity. Priorities include reforming the licensing regime, formulating a spectrum policy and plan, and reinventing the National Telecommunications Commission to ensure regulatory independence.
Cooperative Training Program and Member Satisfaction in Calamba City, Laguna, Philippines
Authors: Debasa Annieleah
Published: September 2024

Implementing a training program was a practical relief for the government to eradicate the effect of modern economic scale on marginalized business communities like cooperatives. This study evaluated the effectiveness of the Cooperative Training Program in Calamba City, providing insights into its impact on micro and small cooperative enterprises. It offered detailed feedback on member satisfaction and program outcomes, which can guide necessary improvements to meet participants' needs better. The research utilized a descriptive design and surveyed 14 CLDD employees and 64 Cooperative members operating in Calamba City through a stratified random sampling technique. Specifically, all regular employees of CLDD and Cooperative members from micro-scaled cooperative enterprises who had received the training program were selected as the research sample. Data were collected using Australian Government Standards for a community-based training program called AQTF Survey Form 2007 based on the Quality Indicator Reporting Requirements (2021) and analyzed through statistical treatments, including the simple mean, four-point Likert scale, standard deviation, and Pearson correlation coefficient. The findings show that the CLDD training program was fully implemented, with no notable difference in how CLDD employees and cooperative members rated its execution. Cooperative members expressed high satisfaction with the training, and there was a strong link between how well the program was implemented and their satisfaction levels. In line with these results, the research proposed an enhancement program to improve key areas of the current CLDD training program implementation: training resources, trainer quality, potential and service quality, and product enhancement. The goal is to enhance the overall program and increase satisfaction among cooperative members.
Brechas territoriales y desigualdad de género: un reto demográfico, un desafío democrático
Authors: Domínguez Álvarez José Luis , Rodríguez Sánchez Alicia
Published: September 2024

Como es sobradamente conocido, el reto demográfico y la igualdad de género son dos de las políticas públicas que mayor progreso han experimentado en los últimos años en cualquier Estado democrático, tendencia a la que no ha sido ajena la praxis institucional española. A este respecto, conviene recordar que la integración de la perspectiva de género en la actuación de los distintos poderes públicos es un principio del ordenamiento jurídico y como tal debe observarse y aplicarse en la interpretación de las normas jurídicas, también en aquellas dirigidas a la dinamización socioeconómica del ámbito rural. Conscientes de que las cuestiones de reto demográfico son necesariamente una cuestión de género, en los últimos años el conjunto de las Administraciones públicas ha diseñado e implementado una amplia amalgama de políticas públicas, con efectos dispares, para institucionalizar la perspectiva de género en el ámbito rural español, conocedoras de que ello representa un presupuesto esencial para fortalecer la cohesión social y territorial. Sentadas estas premisas, la obra colectiva que ahora tiene en sus manos pretende esbozar un conjunto de propuestas tangibles e innovadoras que permitan visibilizar la impagable labor que las mujeres rurales vienen desempeñando desde épocas pretéritas en el seno de las comunidades rurales, al tiempo que constituye un manifiesto que aboga abiertamente por el arraigo de la igualdad real y efectiva en estos territorios rurales tradicionalmente olvidados.
La participación política de la mujer en la política local: evolución y perspectivas de futuro
Authors: Mateos Crespo José Luis
Published: September 2024

Como es sobradamente conocido, el reto demográfico y la igualdad de género son dos de las políticas públicas que mayor progreso han experimentado en los últimos años en cualquier Estado democrático, tendencia a la que no ha sido ajena la praxis institucional española. A este respecto, conviene recordar que la integración de la perspectiva de género en la actuación de los distintos poderes públicos es un principio del ordenamiento jurídico y como tal debe observarse y aplicarse en la interpretación de las normas jurídicas, también en aquellas dirigidas a la dinamización socioeconómica del ámbito rural. Conscientes de que las cuestiones de reto demográfico son necesariamente una cuestión de género, en los últimos años el conjunto de las Administraciones públicas ha diseñado e implementado una amplia amalgama de políticas públicas, con efectos dispares, para institucionalizar la perspectiva de género en el ámbito rural español, conocedoras de que ello representa un presupuesto esencial para fortalecer la cohesión social y territorial. Sentadas estas premisas, la obra colectiva que ahora tiene en sus manos pretende esbozar un conjunto de propuestas tangibles e innovadoras que permitan visibilizar la impagable labor que las mujeres rurales vienen desempeñando desde épocas pretéritas en el seno de las comunidades rurales, al tiempo que constituye un manifiesto que aboga abiertamente por el arraigo de la igualdad real y efectiva en estos territorios rurales tradicionalmente olvidados.
Mujeres y poder político municipal. El caso de Castilla y León
Authors: García Santamaría Sandra
Published: September 2024

Como es sobradamente conocido, el reto demográfico y la igualdad de género son dos de las políticas públicas que mayor progreso han experimentado en los últimos años en cualquier Estado democrático, tendencia a la que no ha sido ajena la praxis institucional española. A este respecto, conviene recordar que la integración de la perspectiva de género en la actuación de los distintos poderes públicos es un principio del ordenamiento jurídico y como tal debe observarse y aplicarse en la interpretación de las normas jurídicas, también en aquellas dirigidas a la dinamización socioeconómica del ámbito rural. Conscientes de que las cuestiones de reto demográfico son necesariamente una cuestión de género, en los últimos años el conjunto de las Administraciones públicas ha diseñado e implementado una amplia amalgama de políticas públicas, con efectos dispares, para institucionalizar la perspectiva de género en el ámbito rural español, conocedoras de que ello representa un presupuesto esencial para fortalecer la cohesión social y territorial. Sentadas estas premisas, la obra colectiva que ahora tiene en sus manos pretende esbozar un conjunto de propuestas tangibles e innovadoras que permitan visibilizar la impagable labor que las mujeres rurales vienen desempeñando desde épocas pretéritas en el seno de las comunidades rurales, al tiempo que constituye un manifiesto que aboga abiertamente por el arraigo de la igualdad real y efectiva en estos territorios rurales tradicionalmente olvidados.
La nueva PAC y su promoción de la mujer rural
Authors: García García Sara
Published: September 2024

Como es sobradamente conocido, el reto demográfico y la igualdad de género son dos de las políticas públicas que mayor progreso han experimentado en los últimos años en cualquier Estado democrático, tendencia a la que no ha sido ajena la praxis institucional española. A este respecto, conviene recordar que la integración de la perspectiva de género en la actuación de los distintos poderes públicos es un principio del ordenamiento jurídico y como tal debe observarse y aplicarse en la interpretación de las normas jurídicas, también en aquellas dirigidas a la dinamización socioeconómica del ámbito rural. Conscientes de que las cuestiones de reto demográfico son necesariamente una cuestión de género, en los últimos años el conjunto de las Administraciones públicas ha diseñado e implementado una amplia amalgama de políticas públicas, con efectos dispares, para institucionalizar la perspectiva de género en el ámbito rural español, conocedoras de que ello representa un presupuesto esencial para fortalecer la cohesión social y territorial. Sentadas estas premisas, la obra colectiva que ahora tiene en sus manos pretende esbozar un conjunto de propuestas tangibles e innovadoras que permitan visibilizar la impagable labor que las mujeres rurales vienen desempeñando desde épocas pretéritas en el seno de las comunidades rurales, al tiempo que constituye un manifiesto que aboga abiertamente por el arraigo de la igualdad real y efectiva en estos territorios rurales tradicionalmente olvidados.
Mujer rural, conciliación y cuidados: la importancia de la provisión de servicios públicos
Authors: Talavera Cordero Pilar
Published: September 2024

Como es sobradamente conocido, el reto demográfico y la igualdad de género son dos de las políticas públicas que mayor progreso han experimentado en los últimos años en cualquier Estado democrático, tendencia a la que no ha sido ajena la praxis institucional española. A este respecto, conviene recordar que la integración de la perspectiva de género en la actuación de los distintos poderes públicos es un principio del ordenamiento jurídico y como tal debe observarse y aplicarse en la interpretación de las normas jurídicas, también en aquellas dirigidas a la dinamización socioeconómica del ámbito rural. Conscientes de que las cuestiones de reto demográfico son necesariamente una cuestión de género, en los últimos años el conjunto de las Administraciones públicas ha diseñado e implementado una amplia amalgama de políticas públicas, con efectos dispares, para institucionalizar la perspectiva de género en el ámbito rural español, conocedoras de que ello representa un presupuesto esencial para fortalecer la cohesión social y territorial. Sentadas estas premisas, la obra colectiva que ahora tiene en sus manos pretende esbozar un conjunto de propuestas tangibles e innovadoras que permitan visibilizar la impagable labor que las mujeres rurales vienen desempeñando desde épocas pretéritas en el seno de las comunidades rurales, al tiempo que constituye un manifiesto que aboga abiertamente por el arraigo de la igualdad real y efectiva en estos territorios rurales tradicionalmente olvidados.
Derecho al trabajo, perspectiva de género y reto demográfico: políticas públicas de empleo femenino en clave territorial
Authors: García-García Ana
Published: September 2024

Como es sobradamente conocido, el reto demográfico y la igualdad de género son dos de las políticas públicas que mayor progreso han experimentado en los últimos años en cualquier Estado democrático, tendencia a la que no ha sido ajena la praxis institucional española. A este respecto, conviene recordar que la integración de la perspectiva de género en la actuación de los distintos poderes públicos es un principio del ordenamiento jurídico y como tal debe observarse y aplicarse en la interpretación de las normas jurídicas, también en aquellas dirigidas a la dinamización socioeconómica del ámbito rural. Conscientes de que las cuestiones de reto demográfico son necesariamente una cuestión de género, en los últimos años el conjunto de las Administraciones públicas ha diseñado e implementado una amplia amalgama de políticas públicas, con efectos dispares, para institucionalizar la perspectiva de género en el ámbito rural español, conocedoras de que ello representa un presupuesto esencial para fortalecer la cohesión social y territorial. Sentadas estas premisas, la obra colectiva que ahora tiene en sus manos pretende esbozar un conjunto de propuestas tangibles e innovadoras que permitan visibilizar la impagable labor que las mujeres rurales vienen desempeñando desde épocas pretéritas en el seno de las comunidades rurales, al tiempo que constituye un manifiesto que aboga abiertamente por el arraigo de la igualdad real y efectiva en estos territorios rurales tradicionalmente olvidados.
Outcomes of Traditional Excisional Management of Breast Cysts with Ultrasonographical Guidance
Authors: Zahid Maria , Haq Najam Ul , Malik Zahra Nayab , Azeem Hamdia , Ibrahim Muhammad , Adnan Ghania , Shahid Muhammad Nauman
Published: September 2024

Background: Surgery for breast cysts may be necessary for symptom relief or to rule out malignancy. Compared to palpation alone, ultrasound guidance provides better accuracy and outcomes. Objectives: This study aimed to assess the efficacy of conventional excisional therapy of breast cysts under ultrasonographic supervision. Ultrasound-guided excision allows precise localization of the lesion, potentially leading to better results than palpation-guided methods. Methodology: A prospective study was conducted from January 2023 to May 2024 on 40 patients undergoing excisional management of benign breast cysts. Patients were divided into two groups: Group A (n=20) underwent ultrasound-guided excision, while Group B (n=20) had palpation-guided excision. Outcomes measured included recurrence rates, cosmetic satisfaction, and post-operative complications. Statistical analysis was performed using SPSS version 28.0, employing independent t-tests for continuous variables and chi-square tests for categorical data. p ≤0.05 was considered statistically significant. Results: The recurrence rate was 5% in the ultrasound-guided group, compared to 20% in the palpation-guided group (p = 0.03). Cosmetic satisfaction was significantly higher in the ultrasound-guided group, with 85% reporting good to excellent outcomes, compared to 55% in the palpation group (p = 0.02). Post-operative complications, including hematoma and infection, were lower in the ultrasound-guided group. Conclusion: Ultrasound-guided excision of breast cysts is less invasive, with increased accuracy, lower recurrence, and improved cosmetic outcomes compared to palpation-guided excision. It should be considered the first-line treatment for benign breast cyst excision.
O IMPACTO DO MOVIMENTO EMPRESA JÚNIOR EM MICRO E PEQUENAS EMPRESAS
Authors: Uchôa Ana Sofia , Ângelo Joaquim , Lira Letícia Albuquerque Maranhão De
Published: September 2024

O Movimento Empresa Júnior (MEJ), nascido na França em 1967, encontra seu maior contingente operacional no Brasil em 2024, presente no país desde 1987. Neste processo, com a criação do Planejamento Estratégico da Rede, documento realizado trienalmente desde 2007 cujo o conteúdo visa unir o Movimento Empresa Júnior em prol de objetivos e metas em comum, o MEJ consegue posicionar pessoas com uma forte educação empreendedora em diversas instâncias do primeiro ao terceiro setor, auxiliando o sucesso e desenvolvimento de inúmeras instituições. O presente artigo busca entender e aprofundar como o Movimento Empresa Júnior, conhecido comumente como MEJ, consegue influenciar um panorama de menor porte, auxiliando na disposição de tomadores de decisão em organizações de até 50 colaboradores.
REJUVENESCIMENTO FACIAL NA BIOMEDICINA ESTÉTICA
Authors: Souza Lorena Leticia Jesus de , Freitas Gabriel Lima de
Published: September 2024

The general objective of the theme was to investigate the impact of facial rejuvenation on aesthetic biomedicine, addressing aspects related to safety, effectiveness and patient satisfaction. Thus, he sought to discuss facial aging; evaluate the main facial rejuvenation procedures available in aesthetic biomedicine, including techniques, products and technologies used; analyze the clinical and scientific aspects involved in facial rejuvenation treatments, considering the benefits, risks and limitations of each approach. The methodology adopted consists of carrying out a literature review, through a bibliographic survey. Studies will be searched in the Virtual Health Library (VHL), PubMed and Google Scholar databases. To select articles, the following descriptors are used: biomedicine; aesthetics; aging. The inclusion criteria established were direct relevance to the topic; publication in Portuguese and/or English; publication period between 2010 and 2024; availability of the full article. Articles that fell outside the scope of the study, were published in languages other than Portuguese and English, published before 2010, available only as abstracts and duplicates in different databases were excluded from the analysis. With the results of the research, it was possible to conclude that facial rejuvenation in aesthetic biomedicine offers a variety of techniques, from chemical peelings to laser procedures and dermal fillers, adapted to the individual needs of each patient. The personalized approach ensures effective and safe results, driven by a comprehensive understanding of scientific principles and a multidisciplinary approach. These innovative treatments promote not only aesthetic improvements, but also patients’ self-esteem and well-being.
Ökumenisches Tauwetter zwischen Zürich und Einsiedeln: Freundschaftliche Beziehungen zwischen Einsiedler Mönchen und Zürcher Theologen im ausgehenden 18. Jahrhundert
Authors: Fässler Thomas
Published: September 2024

In the second half of the 18th century, a close friendship developed between some Catholic Benedictine monks of Einsiedeln Abbey and Protestant Zurich theologians, which resulted in a fruitful exchange of their views on questions of faith. The Enlightenment’s emphasis on tolerance not only made them lay aside any denominational quarrels and prejudices but also made them wish to reunite the two churches as their ultimate goal. Other reasons for these contacts, reflected in a lively correspondence, were as follows: curiosity, an intellectual interest in the theological positions of the opposing views as well as a desire to use the opportunity to express their own convictions without any polemics. Likewise, they saw the need to counteract anti-revelation and anti-ecclesiastical movements generated by the tenets of the Enlightenment. They realized that as a united body they would be much more powerful, and this may have led both sides to this rapprochement. In all of this, however, the monks were firmly convinced that they were on the side of the truth. Therefore, they were careful not to deviate from the Roman path of salvation while building friendships with some Protestants. For the monks, a reunion of the churches was only conceivable if and when the Reformed theologians returned to the bosom of the Catholic Church under the primacy of the Pope. In the course of history, as from 1789, the monks cancelled their recently formed ties with the Protestants, mainly because of the monks’ rejection of the anti-ecclesiastical forces of the Enlightenment and the French Revolution, which again was directed against everything non-Catholic. With the rise of Ultramontanism in the 19th century, they deliberately set out to forget these relationships. After a few decades, the remarkable ecumenical relaxation was replaced by cooler mutual relations.
Alfred Ehrensperger, Geschichte des Gottesdienstes in Zürich Stadt und Land, 2019
Authors: Albisser Ariane
Published: September 2024

No abstract available.
Die Vorrede zur Froschauer Bibel von 1531: Einleitung, annotierte Übersetzung, Transkription
Authors: Opitz Peter , Jörg Ruth
Published: September 2024

There is no author’s name in the preface to the Froschau Bible of 1531. However, everything indicates that it is from Leo Jud, who drafts it on behalf of a group of translators and editors. The purpose is to motivate and guide broad public readers to read the Bible. The Froschau Bible of 1531 contains, for the first time, not only the New Testament, but also the entire Old Testament and the apocryphal books in German translation. Accordingly, the preface gives a brief introduction to the Old Testament books and the Apocrypha. It is obvious that the Zurich Reformation appreciatively falls back on the works of Erasmus as well as drawing on Augustine. Reformation and humanism are not contradictory in the Zurich Reformation. Rather, humanism is incorporated into the Reformation. This is also the case in the preface to the Froschau Bible. However, a closer look reveals that the references to Erasmus are selective and critical. While Erasmus, influenced by the mystical Theology of Pseudo-Dionysius, sees the Bible as a guide to piety and the promotion of Christian virtues on a spiritual path leading to God, the preface presents the Bible as theocentric: it bears witness to God’s activity and revelation and is the place where God encounters human beings. It is deeply rooted in Zwingli’s theology. While in the Roman Church, the sacraments administered by priests were the place where the encounter with God took place, this now became the reading of the Bible. It was to be read not only in church worship service, but also in families. With the spread of the Bible in vernacular languages, the congregation was made mature and removed from the control of the church hierarchy.
124. Jahresbericht des Zwinglivereins über das Jahr 2020
Authors: N.N.
Published: September 2024

No abstract available.
The Collaboration between nurses in a vaccination day against COVID-19 in a meat industry in Lleida Health Region
Authors: Soler Saña Meritxell , Puiggené Montserrat
Published: September 2024

The need for a collaboration between the public health system (PHS) nurses and the occupational nurses from occupational risk prevention services (ORPS) was made evident during the Covid-19 pandemic. In Catalonia, several examples of beforementioned necessity were seen. This document analyses the experience both PHS nurses and ORPS nurses had during the vaccination program of a meat industry workers. It was concluded that coordination and synchronization between both parts is, not only possible, but also key in bettering health markers at a community level. Planning and intervention from an occupational standpoint have proven effective and opens the door to future collaborations between occupational nurses and other nursing specialties.
Occupational biological risk in healthcare workers
Authors: ROMERO-SALDAÑA MANUEL
Published: September 2024

Biohazardous occupational accidents represent a significant challenge in the healthcare field due to the constant exposure of healthcare workers to pathogens. These accidents, which include needle sticks, cuts, splashes of body fluids, and contact with contaminated materials, can lead to serious infections, such as hepatitis B (HBV), hepatitis C (HCV), and HIV.
World Health Organization (WHO) estimates that approximately two million healthcare workers experience sharps injuries annually, resulting in a significant risk of exposure to blood-borne pathogens [1]. A study conducted in hospitals in Europe revealed that the prevalence rate of needlestick injuries ranges from 10% to 30% per year, with the highest rates in areas such as surgery and intensive care [2]. The high frequency of these incidents underscores the importance of implementing effective preventive strategies to protect these workers.
Addressing health disparities. Measuring body composition as a complementary predictor of cardiovascular risk
Authors: Alcañiz-Martín Fátima , Arenal-Ferreira Elena , Martínez-Martínez Valle , Gómez-Paredes Laura , Muñoz-Gutiérrez Juan , Pérez-Herreras María Cristina
Published: September 2024

Introduction. Obesity, increased waist circumference and elevated visceral fat are positively correlated with cardiovascular disease (CVD) risk, in contrast to Mediterranean Diet. Objective: To analyze the association between increased waist circumference (WC), visceral fat (VF), body mass index (BMI), age, sex, total cholesterol, total fat percentage, muscle mass and adherence to a Mediterranean Diet.
Methods. 566 office workers with increased WC (WHO criteria) were included in this multicentre, cross-sectional observational study, when they attended to their job-specific health checkup in Madrid (2023). BMI and body fat distribution (VF, total fat and muscle mass) was obtained using bioimpedance (TANITA™). Sex, age, waist circumference, total cholesterol and PREDIMED questionnaire (adherence to Mediterranean diet) were also collected.
Results. 95.3% of the employees were obese or overweight (BMI). 76.3% had increased TF or were in the obese range. 63% had medium or low adherence to the Mediterranean diet. 50.5% had normal visceral fat. 51.2% had normal cholesterol levels.  High VF showed a statistically significant association (P<0.001) with BMI ≥30 (obesity).Being male was associated to greater obesity (P<0.001), high VF (P<0.001) and lower adherence to the Mediterranean diet (P<0.03).Being a woman was associated to high TF (P<0.001).A low adherence to the Mediterranean diet was associated to more VF (P<0.017).
Conclusions.Individual CVR prediction can be completed by clinicians using tools like bioimpedance that considers sex, VF, TF, in addition to BMI and WC.
A PHILOSOPHICAL CHRISTOLOGY OF XAVIER TILLIETTE
Authors: Tritten Tyler
Published: September 2024

This study has two aims: 1) to provide a concrete instance of how revelation critiques and enlarges philosophy, of how faith dictates to reason, and 2) to draft an outline of a philosophical christology that would fall squarely within the confines of Xavier Tilliette’s own operative principles. Consequently, if revelation is kenotic, then philosophy must also sketch a general ontology that is also kenotic. In other words, if revelation critiques and enlarges philosophy, then kenosis is not exceptional but paradigmatic and so philosophical ontology and philosophical theology must be kenotic all the way down. This article is an attempt to sketch the latter, i.e. a thoroughly kenotic philosophical theology.
An Interview with Dr. Roger Lee
Authors: Vietgen Peter , Black Joanna
Published: September 2024

Never before has the change from face-to-face teaching been so challenged as during COVID-19. In order to understand the present, we turn to the past. The interviewers interviewed Dr. Roger Lee about his first online Art Education program in Canada to shed light on our new day-to-day reality for many of turning to virtual teaching and learning on online platforms.
AI in the posthuman art classroom
Authors: Pente Patti , Adams Cathy
Published: September 2024

This article explores the use of AI-generated art as a way to educate visual art
students and teachers about ethical concerns related to artificial intelligence. For
example, gender and racial bias in the data sets that artificial intelligence trains on
remains a significant concern. Art educators can proactively address these issues by
supporting their students in understanding the ethical issues surrounding AI that will
continue to arise. We advocate for a posthuman approach to AI, treating it not as a mere
tool but as a collaborator in the creative process. Through an examination of AI-artists who
critique AI, we show that AI-artmaking has the potential to be a valuable addition to the
art classroom, allowing both students and teachers to explore and grapple with the ethical
challenges associated with AI.
My Curious Day with George: Dr. Szekely Prescribes Play to a Visiting Artist-Teacher
Authors: Weir Jamia
Published: September 2024

This article presents a personal visit between art teacher/artist, Jamia Weir and Dr. George Szekely, a well known figure in the field of art education and a proponent of “Play Based Art Education.” Weir outlines ideas and sentiments gleaned from a day “picking the brain” of her “art teacher hero.” The conversation took place in the Hudson River Valley in July of 2021.
Beyond the fridge: Opening zones of agency with young artists
Authors: Bauberger Nicole
Published: September 2024

Covid introduced constraints into art and art education programming which challenged art programmers and educators to consider the art of the possible. I will draw on my art and teaching practices during that time as well as my stint as emerging curator of the Yukon Arts Centre Youth Gallery to consider how working locally and outdoors, with a view to future use of the artworks made, shaped successful programs. I will share images and reflections from the Winter Garden, the Monster Parade, and interactive works in the Dalton Trail Trail Gallery, considering the following questions: How does making artwork that has a plan for use in public presentation change the art learning environment? What new levels of unanticipated meaning occur when student artwork encounters its wider community? What opportunities did Covid-related constraints open for us, and what should we make sure and carry with us into the future?
In silico design of sitagliptin bioisosteres as new inhibitors of Mpro SARS-CoV-2
Authors: Abad-Giron Abelardo , Asmad-Cruz Lucero , Cordova-Muñoz Angella M. , Gamarra-Sanchez Cesar D. , Silva-Correa Carmen R. , Villarreal-La Torre Víctor E.
Published: September 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that caused the last major pandemic and has led to multiple efforts being carried out around the world to investigate molecules such as specific chemotherapy drugs against this virus, such as the drug Sitagliptin, which inhibits Mpro, a protease of the virus, by acting on a highly conservative substrate recognition pocket in different coronaviruses. The study aims to develop new compounds under bioisosteric replacement techniques and obtain new SARS-Cov-2 Mpro inhibitors that are more effective than Sitagliptin. For this, 50 bioisosteric derivatives of Sitagliptin were designed, and the pharmacodynamic, pharmacokinetic, and physicochemical properties were analyzed. First, the physicochemical properties of oral absorption were analyzed according to the principles of Lipinski and Veber. The molecular docking was carried out between the protease Mpro (Protein Data Bank Code 7BB2) and the 26 bioisosteres that had the best oral absorption, with the bioisosteres modified in 2,4,5-trifluorophenyl being those that presented a lower affinity energy than that of Sitagliptin. In addition, molecules with pyrrole-pyrazole or similar groups have better pharmacokinetic properties. It is concluded that the pyrrole-pyrazole carboxamide derivative molecule has better energy affinity and ligand efficiency than the other bioisosteres; additionally, it has adequate pharmacokinetic properties, so it would be the best candidate to continue in in vitro or in vivo studies.
Angelica keiskei leaves extract attenuates psychosocial stress in overcrowding-subjected rats
Authors: Siswanto Ferbian Milas
Published: September 2024

Angelica keiskei is currently used as a popular functional food with various beneficial effects, including antioxidant, anti-obesity, anti-tumor, anti-diabetic, and anti-bacterial. A recent in vitro study reported that A. keiskei inhibits monoamine oxidases (MAOs), suggesting the antidepressant property of A. keiskei. However, in vivo studies on laboratory animals subjected to psychosocial stress have not been conducted. In this study, the effects of an A. keiskei leaf extract (AKE) on rats undergoing chronic social overcrowding stress were explored. Six-month-old male and female Wistar rats were housed in groups of three in 12 × 12 × 18 cm cages (overcrowding) for 28 days. Both male and female rats were divided into two groups (N = 10); the control group received oral distilled water, while the other group (treatment group) received 20 mg/kgBW/day of AKE supplementation. The results showed that AKE-treated rats exhibited lower anxiety- and depressive-related behaviors than that of control-stressed rats. AKE significantly decreased corticosterone and increased testosterone and estrogen levels in stressed rats. Additionally, brain tissue malondialdehyde and TNF-alpha levels were reduced, while brain neurotransmitter 5-hydroxytryptamine and antioxidant superoxide dismutase levels were elevated by the AKE. These findings suggest, for the first time, that AKE could alleviate overcrowding stress-induced behavioral, neuroendocrine, antioxidant, and inflammatory dysfunctions. AKE extract could potentially be used as an agonist to reduce stress and depression.
Root-specific secondary metabolism at the single-cell level: a case study of theanine metabolism and regulation in the roots of tea plants (Camellia sinensis)
Authors: Lin Shijia , Zhang Yiwen , Zhang Shupei , Wei Yijie , Han Mengxue , Deng Yamei , Guo Jiayi , Zhu Biying , Yang Tianyuan , Xia Enhua , Wan Xiaochun , Lucas William J , Zhang Zhaoliang
Published: September 2024

Root-synthesized secondary metabolites are critical quality-conferring compounds of foods, plant-derived medicines, and beverages. However, information at a single-cell level on root-specific secondary metabolism remains largely unexplored. L-theanine, an important quality component of tea, is primarily synthesized in roots, from which it is then transported to new shoots of tea plant. In this study, we present a single-cell RNA sequencing (scRNA-seq)-derived map for the tea plant root, which enabled cell-type-specific analysis of glutamate and ethylamine (two precursors of theanine biosynthesis) metabolism, and theanine biosynthesis, storage, and transport. Our findings support a model in which the theanine biosynthesis pathway occurs via multicellular compartmentation and does not require high co-expression levels of transcription factors and their target genes within the same cell cluster. This study provides novel insights into theanine metabolism and regulation, at the single-cell level, and offers an example for studying root-specific secondary metabolism in other plant systems.
Reduction of Cr(VI) by Bacillus toyonensis LBA36 and its effect on radish seedlings under Cr(VI) stress
Authors: Tan Aobo , Wang Hui , Zhang Hehe , Zhang Longfei , Yao Hanyue , Chen Zhi
Published: September 2024

Chromium, being among the most toxic heavy metals, continues to demand immediate attention in the remediation of Cr-contaminated environments. In this study, a strain of LBA36 (Bacillus toyonensis) was isolated from heavy metal contaminated soil in Luanchuan County, Luoyang City, China. The reduction and adsorption rates of LBA36 in 30 mg·L−1 Cr-containing medium were 97.95% and 8.8%, respectively. The reduction mechanism was confirmed by Fourier-transform infrared spectroscopy, and X-ray photoelectron spectroscopy (XPS). Cr(VI) reduction by this strain predominantly occurred outside the cell, with hydroxyl, amide, carboxyl, C-N group, carbonyl, and sulfur carbonyl as the main reaction sites. XPS analysis revealed the presence of Cr2p1/2 and Cr2p3/2. Furthermore, the hydroponic experiment showed that the fresh weight and plant height of radish seedlings increased by 87.87% and 37.07%, respectively, after inoculation with LBA36 strain under 7 mg·L−1 Cr(VI) stress. The levels of chlorophyll, total protein, malondialdehyde, superoxide dismutase and catalase were also affected to different degrees. In conclusion, this study demonstrated the potential of microbial and phytoremediation in the treatment of heavy metal toxicity, and laid the foundation for the development of effective bioremediation methods for Cr(VI) pollution.
The effect of gene polymorphism on ticagrelor metabolism: an in vitro study of 22 CYP3A4 variants in Chinese Han population
Authors: Hu Xiaoxia , Wang Peng , Zeng Dali , Hu Guo-xin
Published: September 2024

Background

Ticagrelor is a novel oral antiplatelet agent which can selectively inhibit P2Y12 receptor. Bleeding and dyspnea are common adverse reactions of ticagrelor in clinic. The side effects of ticagrelor are correlated with the plasma concentration of ticagrelor.

Objective

This study aimed to evaluate the catalytic characteristics of 22 CYP3A4 alleles identified in the Chinese Han population on the metabolism of ticagrelor in vitro, focusing on the effect of CYP3A4 polymorphism on ticagrelor metabolism.

Methods

In this study, insect cells were used to express 22 CYP3A4 variants, which were then incubated with 1–50 µM ticagrelor at 37 °C for 30 minutes to obtain the metabolite (AR-C124910XX). AR-C124910XX was detected by UHPLC-MS/MS to calculate the kinetic parameters, including Km, Vmax and CLint.

Results

Compared to the wild-type, most CYP3A4 alleles exhibited significant differences in intrinsic clearance. The intrinsic clearance of CYP3A4*11, *18 and *33 was much higher than that of wild-type; four variants exhibited similar intrinsic clearance values as the wild-type enzyme; The remaining 14 variants showed significantly reduced intrinsic clearance values, ranging from 1.48% to 75.11% of the wild-type; CYP3A4*30 displayed weak or no activity.

Conclusion

This study conducted a comprehensive assessment of the effect of CYP3A4 variants on ticagrelor’s metabolism. The results suggested that there is allele-specific activity towards ticagrelor in vitro. These findings can provide some insights and predictions for treatment strategies and risk assessments associated with ticagrelor in clinical practice.
Morphometric analysis of the skull base and palatal regions for gender identification using CBCT: a retrospective study
Authors: Uthman Asmaa , Marei Hesham , Elsayed Walid , Al-Bayati Sura F. , Shams Aldeen Hawraa , Shetty Shishir , Saeed Musab Hamed , Al-Rawi Natheer H.
Published: September 2024

Objectives

The objectives of this study were to evaluate the accuracy of morphometry of skull base and palate in gender discrimination using cone beam computed tomography (CBCT) scanning and to assess the accuracy of the results among a sample of the Arab population

Materials & Methods

Using CBCT scans, a cross-sectional analysis was conducted on 142 consented patients who underwent various dental procedures at the University Dental Hospital, Sharjah (UDHS). Of these patients, 70 were females and 72 were males, with respective means of 38.5 and 36.2 years. Eleven parameters related to skull base and palatal region were measured on the CBCT scans by two expert radiologists followed by statistical analysis.

Results

There was significant gender-based difference in the mean palatal width (PW) (p = 0.001), mean palatal height (PH) (p = 0.005). Among other skull base region parameters that were significant in term of gender-based difference like; the clivus length (CL) (p < 0.001), occipital condyle height (OCH) (p < 0.001), basal angle (BA) (p = 0.006) and transverse diameter of foramen magnum (p = 0.003). Only palate variables showed a significant age difference. Discriminant analysis related to gender showed that occipital condyle height was the most accurate and best discriminator among the skull base region parameters.

Conclusion

The use of discriminant analysis in CBCT based on skull base and palatal region variables provides an efficient method for determining gender, which is particularly valuable in forensic science and anthropological research.

Significance of study

Accurate gender identification is crucial in forensic investigations, and the skull base region, being a stable and sexually dimorphic anatomical feature, can serve as a reliable marker for this purpose.
The relationship between the severity and complications of Henöch-Schönlein purpura in children and dietary inflammatory index: a retrospective cohort study
Authors: Chen Jinshu , Chen Pihou , Song Yijin , Wei Jiaxin , Wu Shiya , Wu Fan , Xu Zhiquan
Published: September 2024

Purpose

To investigate the association between the Dietary Inflammatory Index (DII) and disease severity as well as complications in children diagnosed with Henöch-Schönlein purpura (HSP), shedding light on the potential influence of dietary factors on HSP.

Methods

A retrospective cohort study was conducted, enrolling children aged 2–14 years diagnosed with HSP. Participants were divided into low and Pro-inflammatory dietary groups based on their DII scores. Biomarkers, nutrient intake, blood lipid profiles and disease complications were compared between the two groups. Spearman correlation analysis was performed to assess the relationship between DII and complications.

Results

A total of 115 patients, including 56 patients with anti-inflammatory dietary and 59 with pro-inflammatory dietary, were included. The pro-inflammatory dietary group demonstrated significantly elevated of C-reactive protein, tumor necrosis factor-α, interleukin-6, erythrocyte sedimentation rate, white blood cell count, eosinophils, IgE, consumption of total calories, protein, carbohydrates, fiber, fat intake, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, VLDL cholesterol, complications of renal, skin, gastrointestinal, coagulation and respiratory in comparison to the anti-inflammatory dietary group. DII was positively correlated with renal, skin, gastrointestinal, coagulation and respiratory complications.

Conclusion

The study highlights the potential influence of dietary inflammatory potential, as quantified by the DII, on disease severity and complications in children with HSP. Understanding the interplay between dietary patterns and inflammatory responses in pediatric vasculitis has implications for the management of HSP, emphasizing the relevance of considering dietary interventions to optimize clinical outcomes and improve the overall well-being of affected children.
O ENSINO DO CONCEITO DE ÁREA DO PARALELOGRAMO ATRAVÉS DA RESOLUÇÃO DE PROBLEMAS
Authors: Friedel Caroline , Vanderlinde da Silva André
Published: September 2024

Neste artigo, apresentam-se os resultados de uma pesquisa realizada com estudantes do 8º ano do Ensino Fundamental de uma escola pública estadual. O objetivo é investigar as contribuições do uso da Metodologia de Ensino-Aprendizagem-Avaliação de Matemática através da Resolução de Problemas no ensino do conceito da área do paralelogramo. A pesquisa possui caráter qualitativo e os dados foram construídos a partir da observação, da análise da documentação das resoluções dos estudantes e das transcrições das interações dos estudantes entre si e com a pesquisadora. Ao longo da pesquisa, os estudantes resolveram um problema que exigia o cálculo de área do paralelogramo e, em seguida, buscaram uma generalização para o cálculo da área desse polígono. Os resultados da análise de dados indicam que o ensino através da Resolução de Problemas promove o desenvolvimento da proficiência do conceito de áreas, possibilitando que os estudantes apliquem seus conhecimentos de forma crítica e criativa.
Soil Fertility Changes and Crop Productivity of Banana by Continuous Adoption of Banana-Cowpea Intercropping with Nutrient Management Practices
Authors: S. Sathya, , N.Akila  , K.Velmurugan  , S.Paulpandi  , N.Muthusamy
Published: September 2024

A front line demonstration was conducted in farmer’s field in an area of 8 ha with Poovan Banana variety taken as test crop.  Banana is being cultivated to an extent of 2000 ha in six major banana growing blocks in the Namakkal district, Tamil Nadu. Indiscriminate use of chemical fertilizers and mono cropping of banana leads to widespread deficiency in available nutrients (OC-62%, N -67%, Zn-98%, B-58%). This leads to tremendous yield loss. Hence this study was conducted in randomized block design. From this study, it can be concluded that growing of cowpea as intercrop in banana along with application of integrated nutrient management practice (demo plot) observed higher available nutrient status than farmers practice. Among the all soil parameters, a noticeable increase was 29 kg in available nitrogen and 0.30% in organic carbon observed in soil after incorporation of cowpea along with recommended dose of nutrient application at timely interval.  Growth and yield attributing characteristics also was recorded higher in demo plot than farmers practice (check). Highest banana yield of 34.80 t ha-1 was recorded in the demo plot (KVK intervention from sowing to harvest) whereas farmers practice (check) recorded 30.2 t ha-1. The demo yield proved its superiority by recording 15.07 % yield increase over check and having higher net return of Rs.1,89,543 with BC ratio 2.30 than check.
Study on Unguided Temporary Pacing Via the Jugular Vein at the Mohamed VI University Hospital of Marrakech: Safety, Effectiveness and Practicability
Authors: YAHYA Abdelkarim AIT , KABBOUR Moukhtar BEN , ARABI Fatima , JAMILI Mohammed EL , KARIMI Saloua EL , HATTAOUI Mustapha EL
Published: September 2024

This study evaluates the safety, effectiveness, and feasibility of unguided temporary pacemaker insertion in 348 patients at the Mohamed VI University Hospital of Marrakech. The procedure was performed by cardiology residents and showed a high success rate of 99.71%, with successful access to the right internal jugular vein in 89.66% of cases. The majority of patients (66.38%) achieved venous access on the first attempt, with an average procedure time of 11.5 ± 2.1 minutes. Minor complications were observed in 10.63% of patients, including local hematomas (3.45%), accidental arterial punctures (2.30%), pneumothorax (1.15%), and other issues such as local infections and non-sustained ventricular tachycardia. No deaths attributable to the procedure were reported.
The clinical significance of this study lies in its demonstration that unguided temporary pacemaker insertion is a safe and effective alternative in resource-limited settings, reducing treatment delays and potentially lowering mortality among patients requiring temporary cardiac pacing. Based on these results, it is recommended to encourage clinicians in primary and secondary healthcare settings to adopt this approach to improve access to urgent cardiac care in under-resourced regions.
Optimizing the Growth and Flowering of Gladiolus (Gladiolus grandiflorus L.) cv. Arka Amar: Date of Planting & Gibberellic Acid Effects
Authors: Sangeeta Sushree , Mohanty Sukirti , Jena Subhendu , Kumari V. Lakshmi Prasanna , Nayak Debi Archana , Mohanty Mausumi
Published: September 2024

Twelve treatment combinations of the date of planting and gibberellic acid treatment of the corm were replicated three times in the Randomized Block Design (RBD) factorial concept investigation conducted in Gladiolus (Gladiolus grandiflorus L.) cv. Arka Amar during the 2022–2023 rabi season at SOADU, Bhubaneswar (Odisha). The findings showed that on September 15, the planting date and dipping the corms with 150 ppm GA3 concentration resulted in the maximum number of sprouting (2.56), plant height (62.42 cm), number of floret per spike (20.72), floret length (11.56 cm), rachis length (68.41 cm), vase life (7.33 days), and diameter of harvested corm (5.71 cm). Comparably, on November 15th planting with a 100 ppm GA3 concentration of corm treatment, the number of leaves/plant (14.47) and spike length (88.49 cm) demonstrated the greatest results; on October 15th planting, with a 150 ppm GA3 concentration of corm treatment, the least number of days required for spike initiation (72.73) and total number of corms per plot (67) was concluded. Maximum flowering time of 10.2 days was noted in planting on September 15th, using corms bathed in 100ppm GA3. The optimal way to maximize gladiolus cv. Arka Amar flowering and yield was determined in treatment 15th of September planting with dipping corms at 150 ppm GA3 concentration. In general, the research of maximizing gladiolus development by taking into account planting dates and the impacts of gibberellic acid is crucial for raising scientific understanding of gladiolus agriculture as well as yield, quality, and resource efficiency.