bluuebunny/crossref_metadata_2025 huggingface dataset:
Anticancer Potentiality of Ferula assa-foetida Gum Extract against CT-26, HT-29, SW742 and WiDr Colorectal Cancer Cell Lines
Authors: Ali Alaa Naseer Mohammed , Fayyad Raghad, J. , Nuaman Rasha Saad , Mahmod Zahraa Shakir , Alamery Nagham Dawood
Published: January 2023

Background: Ferula assa-foetida L has several therapeutic effects such as anticancer traits. The aim of this study was investigation of anticancer effect of Ferula assa-foetida gum alcoholic extract against CT-26, HT-29, SW742 and WiDr colorectal cancer cell lines. Methods: The hot extract was obtained by soxhlet using 70% ethanol solvent. Various cell lines were cultured in DMEM medium and in vitro anticancer effects using MTT assay was performed. A dilution (5, 10, 25, 50 and 100µg/mL) of the gum extract were subjected to cell lines in triplicate. and incubated for 24, 48 and 72hrs. The main phytochemicals within the gum extract were detected through Gas and mass chromatography. Results: cytotoxicity rates were observed at 50µg/mL and >100µg/mL, respectively for all cell lines. And morphological change was noticed after 72 hr. application of the gum extract on SW742 cell line. The compounds found in the Ferula assa-foetida L mostly included oxygen-containing sesquiterpenes (45.25%) and sesquiterpenes (30.45%). Conclusion: the viability decreasing was observed for all examined colorectal adenocarcinoma cell lines including SW742, CT-26, HT-29 and WiDr lines depend on time and concentration of the applied extract of F. assa-foetida gum. The potent cytotoxicity was observed in 50-100 µg/Ml. Furthermore, a morphological change was detected after 72 hr. on SW742. A high percentages of anticancer compounds which were detected within the gum extract supports the idea of purifying these components and considering them in cancer drugs, phytochemistry.
Isolation and Molecular Detection of E.coli from Common Respiratory Infections of Poultry in A.P.
Authors: Thopireddy Nagendra Reddy
Published: January 2023

In the present work a total of 228 pooled nasal swabs, 228 pooled tracheal swabs samples from the ailing birds and 152 pooled tracheal tissues, 152 pooled lung tissues from the dead birds were collected from the 19 suspected poultry farms in A.P. and were labelled farm wise and specimen wise. The DNA was extracted from the samples by using Trizol method. The PCR and SYBR Green real time PCR tests was standardized by targeting 16 s rRNA gene. The study found that 12 farms were found to be positive for E.coli, with percent positivity of 63.15% by PCR and 71.2% by SYBR Green Real Time PCR. Among the 12 positive farms, 92(40.35% nasal swabs),106(51.75% tracheal swabs),64 (42.10% tracheal tissues) and 72 (47.36% lung tissues) were positive for E.coli by PCR and 118(49.56% nasal swabs),128(56.14% tracheal swabs),68(44.73% tracheal tissues) and 77(50.65% lung tissues) were positive for E.coli by SYBR Green Real Time PCR, nasal swabs and tracheal swabs were positive with positivity of 40.35 and 51.75% respectively by PCR , 106 and 128, nasal swabs and tracheal swabs were positive with positivity 46.49 and 56.14% by SYBR Green Real Time PCR. This study found that the confirmatory diagnosis of respiratory infections in poultry is accurate when histopathology, isolation and molecular detection methods like PCR and SYBR Green Real time PCR are used.
Politik Hukum Pidana Mati Dalam Pemberantasan Tindak Pidana Korupsi di Indonesia
Authors: Setiawan M. Nanda , Afita Cindy Oeliga Yensi , Zia Halida , Agusta Mario
Published: January 2023

Korupsi merupakan masalah yang besar dan menarik sebagai persoalan hukum yang menyangkut jenis kejahatan yang rumit penanggulangannya, karena korupsi mengandung aspek yang majemuk dalam kaitannya dengan politik, ekonomi, dan sosial-budaya. Di dalam politik hukum pidana Indonesia, korupsi itu bahkan dianggap sebagai suatu bentuk pidana yang perlu didekati secara khusus dan diancam dengan pidana yang cukup berat. Tindak pidana korupsi di Indonesia diatur dalam Undang-undang Nomor 31 Tahun 1999 Jo. Undang-undang Nomor 20 Tahun 2001 tentang Pemberantasan Tindak Pidana Korupsi dapat dirumuskan dalam pasal 2 ayat 1 dan ayat 2 yang menyatakan bahwa pidana mati dapat dijatuhkan jika melakukan korupsi pada keadaan tertentu. Tujuan penelitian ini adalah untuk mengetahui bagaimana politik hukum pidana mati dalam pemberantasan tindak pidana korupsi di Indonesia. Tipe penelitian yang penulis gunakan adalah tipe penelitian yurudis normatif. Hasil dan pembahasan Sebagai negara hukum seperti yang tertulis dalam Undang-Undang Dasar Negara Republik Indonesia Tahun 1945 (UUD NRI 1945) maka sudah pasti hukumlah yang menjadi panglima tertinggi. Kebijakan hukum pidana dapat diartikan dengan cara bertindak atau kebijakan dari negara (pemerintah) untuk menggunakan hukum pidana dalam mencapai tujuan tertentu, terutama dalam menanggulangi kejahatan, memang perlu diakui bahwa banyak cara maupun usaha yang dapat dilakukan oleh setiap negara (pemerintah) dalam menanggulangi kejahatan. Salah satu upaya untuk dapat menanggulangi kejahatan, diantaranya melalui suatu kebijakan hukum pidana atau politik hukum pidana. Kebijakan formulasi hukum pidana mati terhadap pelaku tindak pidana korupsi di Indonesia saat ini tertuang dalam Undang-undang No. 20 Tahun 2001 tentang Perubahan atas Undang-Undang Nomor 31 Tahun 1999 tentang Pemberantasan Tindak Pidana Korupsi, yang ditujukan kepada pelaku tindak pidana korupsi. Pidana mati itu sendiri sudah diatur di dalam Undang-undang Tipikor hanya saja hingga saat ini belum ada satupun pelaku tindak pidana korupsi dijatuhkan hukuman mati.
Implementación de guía teórico-práctica para la realización de proyectos de investigación como objeto de aprendizaje para entornos virtuales
Authors: Romero Parra Rosario Mireya , Barboza Arenas Luis Andres , Romero Chacín Jorge Luis , Faria Romero José Antonio
Published: January 2023

El objetivo del estudio es comprobar la efectividad una guía teórico-práctica como objeto de aprendizaje para entornos virtuales en la realización de Proyectos de Investigación (PI) como objeto de aprendizaje para entornos virtuales en el curso de Metodología de Investigación de la Facultad de Educación de una universidad de Lima Metropolitana del Perú. La investigación se fundamenta en los estudios de Gómez et al. (2020), Hernández-Sampieri y Mendoza (2018), Pástor et al. (2020), Peiris et al. (2018), Pérez-Fuentes (2019), Pilozo-Cedeño (2016) entre otros. La investigación cuenta con un diseño cuasiexperimental. La población la constituyen 358 estudiantes y las unidades de estudio fueron noventa estudiantes correspondientes al curso referido de las secciones: 421 y 422. El estudio de la realización de los PI se desarrolla con las dimensiones contextualización del problema, fundamentación teórica y metodología. Las variaciones en la constitución de las dimensiones con sus respectivos indicadores, después de la aplicación de la guía diseñada, probándose en gran medida discrepancias entre estos, debido a que, el estadístico de t computarizado se encuentra relacionado, a valores de significancia inferiores a 0,01. Por ello, se plantea la guía teórica-práctica como objeto de aprendizaje para entornos virtuales como base para la realización de los PI, puesto que dicha guía; optimiza el conocimiento de lo que se va a realizar, optimiza la comunicación, fomenta la motivación, permite un mejor provecho de los recursos, manifiesta la visión y misión de los estudiantes y ha logrado significativos avances en el desarrollo de los proyectos de investigación de los educandos del curso referido.
Componente semántico en niños de edad preescolar con dificultad de lenguaje en las escuelas del Perú
Authors: Larroca Saavedra Helen Dorothy
Published: January 2023

El lenguaje es una importante herramienta mediante la cual los niños expresan sus pensamientos, sentimientos, emociones y satisfacen sus necesidades básicas. La expresión y la comunicación entre las personas son los medios más importantes para construir relaciones sociales, desarrollar emociones y aprender sobre el entorno que les rodea. Sin embargo, en la actualidad existen niños que presentan muchas dificultades en su lenguaje para comunicarse debido a diversos factores, impactando de manera desfavorable en el ámbito familiar, escolar y social. Por ello, el objetivo del estudio es analizar el componente semántico en niños de edad preescolar con dificultad de lenguaje en las escuelas del Perú, bajo una metodología descriptiva, aplicada. Donde se diseñó un plan de valoración e intervención que respondan a las necesidades y dificultades de los niños de preescolar, utilizando un modelo híbrido, aplicado a una muestra representativa de 37 niños respecto a la población total conformada por 6.846 niños de acuerdo al registro que llevan los Centros de Salud Mental Comunitaria en el Perú, donde los padres llevan a sus hijos para tratar problemas de lenguaje. Se consideraron los fundamentos teóricos de Owens (2003), Sentis, et al (2009), entre otros; quienes realizaron investigaciones previas al tema en cuestión. Los resultados del estudio reflejan un limitado manejo del componente semántico. Este escaso vocabulario se evidenció en los problemas de comprensión, haciendo necesario realizar continuamente terapias de intervención del vocabulario tanto comprensivo como expresivo, para que el niño pueda comprender preguntas, indicaciones e interactuar con su medio familiar y escolar.
Liberalismo en América Latina en el siglo XIX
Authors: Naranjo Navas Christian Paul
Published: January 2023

El escrito realiza una breve revisión de la adaptación de las ideas del liberalismo clásico en América Latina a partir de los procesos de emancipación hasta la segunda mitad del siglo XIX. Se parte del marco conceptual de las ideas liberales surgidas en la Ilustración y en los eventos revolucionario en Francia y Estados Unidos. El objetivo principal del artículo es analizar la adaptación de estas ideas en dos áreas, a saber: política y económica. En el área política se considera la ambivalencia entre democracia y monarquía, la influencia de la religión en el quehacer político, las discusiones sobre la esclavitud y su abolición, y las ideas sobre la nación. En el área económica se examina la influencia teórica de las ideas liberales en América Latina, y las políticas económicas de libre mercado que se implementaron a finales de siglo. Con este propósito, se realiza una revisión histórico-analítica, con base en documentos primarios, como las cartas de Thomas Jefferson y las de Abraham Lincoln, y con base en estudios previos. Esta revisión se enmarca conceptualmente en el Liberalismo Clásico. Se concluye que las ideas del liberalismo sirvieron para la construcción de democracias endebles en la región, las cuales mantenían ciertos beneficios a la Iglesia Católica y, al mismo tiempo, se fortalecían a partir de la apertura al mercado externo como respuesta a la necesidad de materias primas que provenía del incremente industrial en Europa y Estados Unidos.
Pengaruh Profitabilitas, Leverage, Ukuran Perusahaan terhadap Tax Avoidance pada Perusahaan Manufaktur yang Terdaftar di BEI Periode 2017-2020
Authors: Hitijahubessy William Immanuel , Sulistiyowati Sulistiyowati , Rusli Devvy
Published: January 2023

This study aims to determine whether the effect of Profitability, Leverage, and Company Size on Tax Avoidance in manufacturing companies for the 2017-2020 period listed on the Indonesia Stock Exchange. This study uses a quantitative research method using panel data regression as measured by Eviews version 10. The sample was determined based on the purposive sampling method, with a total sample of 64 manufacturing companies so that the total observations in this study were 256 observations. The data used in this study is secondary data in the form of financial reports obtained from the official IDX website: www.idx.co.id and related company websites. Hypothesis testing using t test. The results of the study prove that, (1) profitability has a negative effect on tax avoidance, (2) leverage has a negative effect on tax avoidance, (3) firm size has a positive effect on tax avoidance.
Analisis Fungsi Pengeluaran Pemerintah terhadap Tingkat Pertumbuhan Ekonomi Provinsi Jawa Timur
Authors: Rahmawati Heni
Published: January 2023

Achieving of economic growth and development in a country is a goal to be achieved by a country.  One of the economic data sets that are used as a reference in viewing the economic development of a region is to use economic data derived from Gross Domestic Regional Product.  The value of GRDP reflects the potential for economic growth in a certain area.  In achieving the goal of equitable growth and development, a budget or financing is needed to finance these development activities. These expenses are usually in the form of expenses for operational activities or investments. This research was conducted with the aim of observing and analyzing the impact of expenditures made by local government in relation to economic growth in east java province. This study uses a descriptive qualitative method and takes a sample of East Java government spending data for 2017-2020 and East Java GDRP Growth Rate data for 2017-2020. The results show that government spending affect the level of economic growth in an East Java Province.
Pengaruh Kondisi Sektor Kesehatan terhadap Pertumbuhan Ekonomi di Indonesia
Authors: Aurelya Tasya , Nurhayati Nurhayati , Purba Samuel Fery
Published: January 2023

One of the successes of national development is measured by the increasing economic growth of the country and the increasing quality of public health. A nation's capacity to acquire high-quality human resources in order to produce a sustainable economy is greatly influenced by health. The purpose of this study is to represent and analyze the effects of various factors on Indonesia's economic development, including the percentage of smoking in people aged ≥ 15 years (RKK), the health allocation fund (DAK Health), the percentage of children aged less than 6 months who received exclusive breastfeeding (ASI), the percentage of married women aged 15-49 years (KWN) and unmet need health services (LYN). The panel data method and secondary data from BPS (www.bps.go.id) from 2016 to 2020 are used in this study. The test results show that cigarettes indicator have a negative impact, but the DAK Health indicator, ASI indicator, KWN indicator, and LYN indicator, have a positive impact on aggregate economic growth in 34 Indonesian provinces. With the exception of the islands of Sulawesi, Kalimantan, Java, Bali-Nusa Tenggara, and Sumatra, the results of the investigation in 34 provinces of Indonesia show that cigarettes indicator generally have a positive impact. With the exception of the islands of Maluku-Papua, Java, Sumatra, and Bali-Nusa Tenggara, the DAK Health as a whole have a favorable impact. Overall, the ASI indicator have a favorable impact on economic growth, except for the islands of Maluku-Papua and Bali-Nusa Tenggara. KWN indicator have a positive correlation with economic growth in 34 Indonesian provinces. Finally, LYN indicator have a favorable effect on the aggregate in Indonesia, with the exception of the islands of Sulawesi, Maluku-Papua and Bali-Nusa Tenggara.
COMO PROFESSORES DE LÍNGUA PORTUGUESA DA EDUCAÇÃO BÁSICA CONCEBEM A SEQUÊNCIA DIDÁTICA GÊNEROS?
Authors: Pepis Belinelli Gabriela , Merlin Deganutti de Barros Eliana , Lopes Cristovão Vera Lúcia
Published: January 2023

Os dados analisados neste artigo foram gerados por uma sequência virtual de formação docente (SVFD) implementada como parte integrante de uma pesquisa de mestrado e direcionada a professores de Língua Portuguesa da Educação Básica. O foco da formação foi o ensino do gênero ‘artigo de opinião’ por meio do procedimento ‘sequência didática de gêneros’ (SDG) sistematizado por pesquisadores do Interacionismo Sociodiscursivo (ISD). O objetivo deste trabalho é analisar a concepção dos professores-cursistas em relação à SDG, antes e depois do processo formativo, tomando como ferramenta metodológica dois questionários aplicados durante o curso, um inicial e outro final, com base em uma pergunta específica sobre a SDG. A base teórico-metodológica da pesquisa é o ISD, sobretudo, os estudos voltados à didatização da língua. As análises mostram que a SVFD provocou mudanças na concepção da maioria dos professores, uma vez que passaram a compreender a SDG a partir de suas bases teórico-metodológicas.
O TRABALHO COM SEQUÊNCIA DIDÁTICA NO ENSINO SUPERIOR
Authors: Moretto Milena , Gomes Varisco Alessandra
Published: January 2023

Diversos estudantes ingressam no ensino superior com dificuldades em relação à leitura e produção de textos e essa dificuldade mostra-se patente também nos cursos de Direito, o que pode prejudicar o estudante em sua trajetória, já que ele se deparará com diversos gêneros textuais desta área que, se não forem bem compreendidos, pode levar a um indeferimento do pedido, quando profissional. Pensando nisso, desenvolvemos um modelo didático e, posteriormente, uma sequência didática do gênero petição inicial para o trabalho com o gênero. Neste artigo, temos como objetivo geral compreender as capacidades de linguagem desenvolvidas pelos estudantes ingressantes do curso de Direito de uma instituição de ensino superior a partir da sequência didática realizada em sala de aula. Pautando-nos, para isso, nas considerações dos didaticistas de Genebra e tomamos como dados de análise a produção inicial e a produção final de um dos participantes da pesquisa. Nossas análises revelam que os alunos desenvolveram as capacidades de ação, discursivas e linguístico-discursivas na produção de textos desse gênero após o trabalho com os módulos apresentado na sequência didática.
INFOGRÁFICOS ANIMADOS NO ENSINO MÉDIO
Authors: Lima Rodrigo da Silva , Silva Núbia Gabriela da Costa , Karlo-Gomes Geam
Published: January 2023

O gênero infográfico animado é muito utilizado nas áreas jornalística e saúde, todavia, nota-se uma lacuna na literatura a respeito do uso desse gênero na educação. O estudo atual objetiva avaliar o ensino de Língua Portuguesa a partir do trabalho com os dispositivos MDG e SD para a produção de infográficos animados. Apoia-se nas orientações acerca desses procedimentos didáticos, duas importantes contribuições de Joaquim Dolz e colaboradores para o ensino e produção de gêneros textuais. Este artigo resulta de uma pesquisa sobre a prática docente realizada nos meses de maio, junho, julho e agosto de 2021, em uma escola da rede pública de ensino do Estado de Pernambuco. Um MDG foi construído para auxiliar na produção da SD para o gênero infográfico animado. Os resultados indicam que os dispositivos MDG e SD viabilizam o trabalho docente, funcionando como ferramentas mediadoras do ensino de gêneros textuais nas aulas de LP. Esses procedimentos didáticos possibilitaram o planejamento e execução de aulas dinâmicas e engajadoras, por meio das quais foi possível incluir TDICs e o trabalho com elementos da cultura digital, bem como a análise e estudo de textos multimodais presentes em diferentes contextos da sociedade. Portanto, constatam-se as contribuições dos estudos de Dolz para a área da educação, sobretudo para o estudo e produção de gêneros textuais no ensino de Língua Portuguesa.
O ESPAÇO DE OCUPAÇÃO DO ENSINO DA ORALIDADE NO TERRITÓRIO CURRICULAR DA FORMAÇÃO EM PEDAGOGIA
Authors: Marinho Ribeiro Roziane , Luna Ewerton Ávila dos Anjos
Published: January 2023

Atualmente é possível identificar uma vasta produção científica em torno do oral/oralidade, tratando de diferentes aspectos que envolvem formação docente, ensino, práticas escolares e outros eixos temáticos. No entanto, o oral/oralidade no contexto de formação de professores dos Anos Iniciais do Ensino Fundamental ainda tem recebido pouca atenção nas pesquisas. Assim, é objetivo deste texto analisar o lugar que a oralidade ocupa na formação de professores pedagogos. Trata-se de uma pesquisa documental que toma como objeto de análise ementas de componentes curriculares da área de linguagem, inseridos em Projetos Pedagógicos de Cursos de Licenciatura em Pedagogia, pertencentes a instituições públicas. A análise, subsidiada pelos construtos teóricos do Interacionsimo Sociodiscursivo, sobretudo pelas contribuições de Dolz; Schneuwly (1996); Colognesi; Dolz (2017), revela que, de fato, a modalidade oral ainda ocupa um espaço periférico no território curricular de Cursos de Pedagogia, o que representa uma lacuna na formação docente e, consequentemente, nas práticas escolares.

Palavras-chave: oral; currículo; Pedagogia.
Representações sociais de suicídio entre voluntários do Centro de Valorização da Vida // Social representations of suicide among volunteers from Centro de Valorização da Vida
Authors: Schettino Lucas Lorena , Bonomo Mariana
Published: January 2023

No Brasil, as taxas de suicídio apresentaram aumento nos últimos anos, configurando o fenômeno como grave problema de saúde pública. O Centro de Valorização da Vida (CVV) e os seus voluntários atuam como principal alternativa filantrópica nacional para a prevenção do suicídio. Compreender como os voluntários do CVV representam o fenômeno se faz necessário para entender as práticas de prevenção realizadas na instituição. Portanto, este estudo objetivou analisar o conteúdo do campo representacional associado ao objeto de representação suicídio pelos voluntários do CVV Vitória/ES. Foram entrevistados 19 voluntários do CVV Vitória/ES, com instrumento baseado em roteiro semiestruturado. Para análise dos dados, foram utilizados os recursos da Análise de Conteúdo. Os resultados apontaram para a organização do campo representacional referente ao suicídio a partir de três categorias temáticas principais: 1) Memórias e vivências: o voluntário do CVV; 2) Risco e proteção; e 3) Suicídio: como o avaliam e como se sentem os voluntários do CVV. Discute-se acerca da dimensão afetiva das representações sociais de suicídio entre os voluntários, bem como a atribuição da adolescência como principal grupo de risco e a ancoragem do objeto de representação suicídio em conhecimentos religiosos e científicos.
ANALISIS RASIO LIKUIDITAS, RASIO SOLVABILITAS DAN RASIO PROFITABILITAS GUNA MENGUKUR KINERJA KEUANGAN PT. KRAKATAU STEEL (PERSERO) TBK TAHUN 2019-2021
Authors: Yuanita Rensa , Suartini Sri , Sulistyo Hari , Hasanuh Nanu
Published: January 2023

This research aims to be able to find out the financial performance of one of the state-owned enterprises (SOEs) which has recently become a hot topic of public discussion because it has managed to pay its debts even though it has suffered losses for many years, namely PT Krakatau Steel (Persero) Tbk. The analysis media used is the ratio of liquidity, solvency and profitability. The data sources used in this observation are financial position statements (balance sheets) and profit and loss statements of PT. PT. Krakatau Steel (Persero) Tbk from 2019-2021 obtained from IDX (Indonesia Stock Exchange). Based on the results of this study liquidity levels, Current Ratio and Quick Rastio showed fluctuation conditions while Cash Ratio showed an increase every year. The solvency level, Debt to Assets Ratio indicates solvable conditions, while Debt to Equity Ratio describes an insolvable state. And the degree of profitability, Gross Profit Margin is afluctuation of Net Profit Margin shows an increase every year,. Return On Assets shows an increase every year and Return On Equity shows an increase every year.
BRIEF REVIEW ABOUT NEUROLOGICAL, HEMATOLOGICAL, GASTROINTESTINAL, CARDIOVASCULAR AND PULMONAR MANIFESTATIONS OF SYSTEMIC ERYTHEMATOSUS LUPUS
Authors: Bryam Esteban Coello García  , Diana Carolina Martínez Pesántez  , José Javier Ordoñez Cabrera  , María Ángel Valarezo Martínez  , Bibiana Alexandra Morales Ordónez  , Fabiana Domenica Palacios Rivera  , Juan Francisco Vidal Moreno
Published: January 2023

Systemic Lupus Erythematosus is an autoimmune multisystem pathology, characterized by being more prevalent in women, especially African women. One of the most frequent pathologies is usually the presence of Lupus Nephritis (1). The prevalence is higher in women in relation to men in a ratio of 9:1, with an age onset between 15 and 44 years of age (2).
Objective: to detail the current information related to cardiovascular, neurological, hematological manifestations of systemic erythematosus lupus, analyzing which pathologies are present in this disease.
Methodology: a total of 32 articles were analyzed in this review, including review and original articles, resulting in the election of 15 bibliographies due to the relevance of them. The sources of information were PubMed, Google Scholar and UpToDate; the terms used to search for information in English was: Systemic Erythematosus Lupus and its manifestations.
Results: The most frequent gastrointestinal manifestations are regurgitation, peptic ulceration, protein-losing enteropathy, pseudo-obstruction and mesenteric vasculitis; neurological manifestations include seizures, stroke, optic neuritis, altered mental status, aseptic meningitis, chorea, psychosis or depression. At the hematologic level, anemia, thrombocytopenia, leukopenia, thrombotic thrombocytopenic purpura is usually manifested, so the patients clinical manifestations should be analyzed and any other etiology of the patient that is not related to systemic lupus erythematosus should be ruled out. Pulmonary manifestations usually include pleuritic pain, lupus pneumonitis, interstitial pulmonary alterations and pulmonary hypertension. Cardiovascular manifestations should be ruled out considering that patients with lupus have an increased risk of cardiovascular disease.
Conclusions: This bibliographic review sought to show the symptoms of patients diagnosed with systemic lupus erythematosus, and which are related to the most important organs; in this case, at the neurological, cardiovascular, pulmonary, hematological and gastrointestinal levels. This review shows us that we must consider several pathologies in patients with Lupus; however, we must remember that the diagnosis of these entities is a rule-out diagnosis, which means that if we have a symptomatology of a certain apparatus or system, we must rule it out with the most frequent, and then consider the less frequent pathology, related to lupus.
KEYWORDS: Systemic lupus erythematous; Protein-losing enteropathy; Treatment.
SIMULATION OF RADIATION IN MICROSYSTEMS USING MARKOV CHAINS
Authors:   Smolensk State University of Sports, Yudenkov A.V. , Volodchenkov A.M. ,   Smolensk Branch of Plekhanov Russian University of Economics, Rimskaya L.P. ,   Smolensk Branch of Plekhanov Russian University of Economics
Published: January 2023

To solve important problems related to radiation in microsystems, the methods of quantum electrodynamics are successfully used. At the same time, a number of problems remain (vacuum energy, divergence in local interaction, the physical meaning of the fine structure constant) that cannot be resolved within the framework of this theory. Therefore, an urgent task is to develop alternative mathematical models that can be additionally used to study the radiation process in microsystems. In this work, to model the radiation process in microsystems, Markov processes with continuous time and discrete states are used. The mathematical model is based on Heisenberg's uncertainty principles and conservation laws. The main mathematical tools are Kolmogorov graphs and their corresponding systems of equations. The key idea is that the phase space of a particle is discrete. The model of the discrete phase space is distinguished by its comparative simplicity and efficiency, and allows applying the well-developed theory of Markov processes to the phenomena under study. The scale of the model and its discrete structure make it possible to avoid irremovable singularities. The article presents: an original physical interpretation of the fine structure constant, a stochastic analogue of the redshift law and the magnitude of the Schwarzschild gravitational radius, a stochastic interpretation of the fine structure constant of the gravitational field is proposed. A comparative analysis of the fine structure constants for the gravitational and electromagnetic fields has been carried out.
METHOD FOR DETERMINING THE PHENOMENON OF STALL ON HELICOPTER BLADE
Authors:   Southwest State University, Mukhin I.E. , Koptev D.S. ,   Southwest State University, Knyazev A.A. ,   Southwest State University, Leon Herman ,   Southwest State University, Shuklina Yu.V. ,   Southwest State University
Published: January 2023

The analysis of dangerous factors leading to the phenomenon of flow stall on the rotor blades of a helicopter has been carried out. The estimated cruising speed of a helicopter without auxiliary propulsion at the current level of technology development lies in the range of 280-370 km/h. The results of flight experiments showed that the stall phenomenon leads to a sharp increase in the load on the blades, which in turn is transferred to the lower fixed plate of the swashplate. This phenomenon is accompanied by the appearance of the n-th harmonic of the main rotor speed. The results of these experiments made it possible to create a subsystem for recognizing the phenomenon of stall with the issuance of visual and audible indication to the pilot to change the flight mode. A block diagram and description of the operation of the subsystem based on the simultaneous use of two features are given: measurement of mechanical stresses on the swashplate and the amplitude of the harmonic component of the signal from the frequency of rotation of the rotor blades of the helicopter. The use of two signs can significantly increase the probability of determining the moment of flow stall. The technical implementation of the proposed method for determining the phenomenon of flow stall on the rotor blades of a helicopter makes it possible to provide a qualitatively new level of flight safety under conditions of complex maneuvers.
REGULARIZING ALGORITHMS BASED ON KALMAN FILTERING FOR M-QAM SIGNAL DETECTION IN MIMO
Authors:   Moscow Technical University of Communications and Informatics, Poborchaya N.E.
Published: January 2023

The aim of the article is to increase the noise immunity of signal reception with a satisfactory computational complexity of signal processing algorithms. The article discusses two regularizing recurrent algorithms for detecting quadrature amplitude modulation (M-QAM) signal in a multiple-input and multiple-output (MIMO) method and a direct transform receiver based on the Kalman filter. Kalman filtering using for soft decision detection operates at a fixed point in time and estimates symbols in iterations. The proposed detection algorithms contain a regularizing parameter. For one algorithm, the regularization parameter is selected empirically, for the other, it is found by a closed expression, which includes estimations of symbols obtained at the last step of the iterative algorithm. Hard decisions are determined by the criterion of the minimum distance between the received soft decisions and the possible values of symbols for each transmitting antenna separately. The proposed detectors are compared in terms of noise immunity (in a system without coding) with the Zero Forsing method and an algorithm that works according to the root-mean-square error (RMS) criterion. The channel is supposed to be known or it is estimated by the least squares (LS) method using first-order polynomial approximation. The article claims that regularizing detection algorithms make it possible to increase the noise immunity of signal reception relative to the Zero Forsing algorithms and RMS. In addition, this article contains an analysis of the computational complexity of the proposed recurrent algorithms. The use of the regularization parameter makes it possible to reduce the number of iterations in the detection algorithm needed to obtain the required error probability per symbol. This can reduce the number of arithmetic operations, resulting in a reduction in the computational complexity of signal processing algorithms. The proposed detection algorithms are more complicated than the Zero Forsing and RMS, but it is much simpler than the detector synthesized according to the maximum likelihood (ML) algorithm.
ADAPTIVE PREDISTORTION DEVICE OF THE SATELLITE TRANSMITTERS
Authors:   JSC “Russian Space Systems”, Petushkov S.V.
Published: January 2023

The improvement of energetic and spectral characteristics of the satellite transmitters which act in the harsh space environment with the help of the predistortion linearization becomes more and more actual task. The proposed adaptive predistortion device is based on the correlation evaluation of the nonlinear distortion level at the output of the power amplifier. The device allows to provide more effective linearization in the conditions with changing characteristics of the satellite transmitter within the lifetime of the satellite at the orbit in difference to the systems with advance tuning. The proposed technical solution has a higher reliability and simplified technical implementation in comparison with the analogs due to lack of the preliminary analog and digital processing of the RF signal. The simplified algorithm which requires lesser logical capacity in the digital microcircuits than conventional adaptive algorithms was developed for the modeling of the adaptive predistortion device. The proposed algorithm of changing the parameters of the predistortion linearizer requires less mathematical calculations within one iteration cycle, which is based on the determination of the cross-correlation function gradient rise direction. The obtained results of proposed predistortion linearizer modeling show that the process of two-dimension adaptation based on the developed algorithm is monosemantic and leads to the recovery of the linearizer’s non-linear characteristics optimal tune. The adaptation process leads to the lowering of the intermodulation distortion at the output of the power amplifier in a few adaptation cycles. It is worth noting that the process of the optimization and selection of the two parameters of the predistortion linearizer in the amplifier flows the same way whatever if the analog of digital implementation of the linearizer is used.
COMPARATIVE ANALYSIS OF STEGOSYSTEMS WITH EMBEDDING IN THE LEAST SIGNIFICANT BITS WITH MATCHING AND SUBSTITUTION
Authors:   The Bonch-Bruevich Saint-Petersburg State University of Telecommunications, Akhrameeva K.A. , Gerling E.U. ,   The Bonch-Bruevich Saint-Petersburg State University of Telecommunications
Published: January 2023

The work presents the results of a comparative analysis of stegosystems with algorithms for embedding in the least significant bit with matching and substitution for differences in the procedure for embedding additional information in the covering object and the resistance of the obtained steganograms to various methods of steganalysis. When using stegosystems with embedding algorithms in the least significant bit with matching and substitution, samples of steganograms with different embedding fractions were obtained for a sample of 200 covering objects. The results of the steganogram analysis on the steganogram data were analyzed, the obtained steganogram samples were compared to the detection of the presence of an additional information attachment using three steganalysis methods: visual attack, first-order statistical attack (chi-square attack) and second-order statistical attack (pairwise selective analysis attack). The presented example of images before and after a visual attack, for samples steganograms with attachments in the least significant bit with substitution and matching, with an investment fraction of 10%, 50% and 100%, allows to demonstrate the performance of the visual method steganalysis. The graphical representation of the results for first-and second-order attacks allows us to evaluate the effectiveness of the studied methods of stegoanalysis for stegosystems with algorithms for embedding in the least significant bit with matching and substitution. It is shown that a stegosystem with an algorithm for embedding in the least significant bits with matching is more resistant to detection attacks using modern methods of stegoanalysis. Conclusions are made about the possibility of applying the considered methods of stegoanalysis to the presented methods of stegosystems
DETECTION TWO-WAVE WITH DIFFUSE POWER FADING
Authors:   S. M. Budenny Military Academy of Communication, Savischenko N.V. , Dyrin V.I. ,   S. M. Budenny Military Academy of Communication, Makarenko V.P. ,   S. M. Budenny Military Academy of Communication
Published: January 2023

One of the main objectives of the mathematical theory of communication is definition of the most essential characteristics of system of information transfer. One of important quantitative indices of system is the probability of erroneous reception in various communication channels. The special class of communication channels is represented by channels in which a dying down of signals is considered. For the mathematical description of a dying down the density of distribution of probabilities is used, in particular. The variety of the various distributions meeting in scientific literature, is connected as with the assumptions used for justification of distribution, and to their compliance to physical properties of channels. In article the dual-beam model with a diffuzny dying down of capacity of a signal (TWDP model) is considered and mathematical statement of a problem of calculation of a noise stability for a communication channel with additive white Gaussian noise and a dying down described within this model is formulated. It is shown that the TWDP model used for the description of a dying down, includes not only a classical releevsky and raysovsky dying down, but also covers a class of two-modal distributions, characteristic for some modern wireless communication channels. It is shown that at certain parameters of distribution there are two fashions which emergence was theoretically possible when using for the description of a dying down of four-parametrical distribution. For the solution of a problem of calculation of a noise stability in the channel with a dying down studying of likelihood characteristics of distribution that demands, in turn, attraction of the theory of special functions and, in particular, hyper geometrical functions is necessary. It is shown that mathematical representation of function of distribution is possible in two options: integrated representation and representation through Laurichell's hyper geometrical function. Ratios for the initial moments of the distribution considered in article are received. It is shown that the initial moments are expressed through Gauss's hyper geometrical function. At the heart of the solution of a problem of a noise stability representation of probability of a symbolical (bit) mistake for multiitem alarm designs in a communication channel with additive white Gaussian noise through Owen's special function that allows to receive the common decision of a task lies. The analytical formulation of the partial task which decision is a basis for the solution of the general problem of calculation of a noise stability in a communication channel with a dying down described by TWDP model is presented.
DETECTION OF A MULTI-CRITERIA INDICATOR OF THE QUALITY OF THE GRAPHICAL INTERFACE OF THE SOFTWARE AND HARDWARE COMMUNICATION COMPLEX
Authors:   S. M. Budyonny Military Academy of communications, Fedorovа S. V.
Published: January 2023

Introduction: increasing the degree of automation of the developed means and communication complexes entails an increase in the complexity of software products for their management. Due to the limited human capabilities, the question arises about the ergonomics of human-machine interfaces, namely, the software user interface, which allows to increase the efficiency of the entire human-machine system. The purpose of the study is to determine the structure and composition of the software user interface, its parameters that affect the reliability of the operator's activities when managing the software and hardware complex of communication. Methods: since modern methods of evaluating software interfaces do not allow for a comprehensive quantitative assessment of its parameters, the solution of the problem is proposed to be carried out using the methods of system theory, revealing quantitative, reliable and objective information about the software user interface under study. The proposed mathematical description of the software user interface is necessary to determine the quality indicator of the interface, reflecting the degree of its ergonomics. Results: the use of the proposed mathematical description of the software user interface based on the definition of the parameters of the elements that make up it, and the further definition of the multi-criteria indicator of its quality and ergonomics will allow us to assess the impact of the values of the parameters of the interface elements on the indicator of its quality, and when designing complex interfaces, changing these parameters will allow us to analyze and identify such parameters of the user interface elements, in which the indicator of its quality has the best values. Practical significance: the presented results are proposed to be used in assessing the functional reliability of promising developed software and hardware communication systems and modeling the process of operator interaction with this complex through a software user interface. Conclusion: the evaluation of the functional reliability of the software and hardware communication complex based on the results of the operator's interaction with the software user interface of the communication complex, the multi-criteria quality indicator of which reflects the degree of its ergonomics, will allow at the design stage of promising software and hardware communication complexes to assess the influence of the parameters of the interface elements on the error-free actions of the operator.
METHODOLOGY FOR MONITORING AND PREDICTING THE TECHNICAL CONDITION OF THE SECONDARY POWER SUPPLY SYSTEM OF FIELD COMMUNICATION OBJECTS BASED ON A NEURAL NETWORK CAMPAIGN
Authors:   Military academy of communications named after Marshal of the Soviet Union S.M. Budyonny, Abramkin R.V. , Pedan A.V. ,   Military academy of communications named after Marshal of the Soviet Union S.M. Budyonny, Vinogradenko A.M. ,   Military academy of communications named after Marshal of the Soviet Union S.M. Budyonny
Published: January 2023

Introduction: сurrently, the control of the technical condition of complex technical systems, such as the secondary power supply system of field communication facilities, is a long and non-automated process that is carried out by operators directly at the control facilities themselves. This circumstance has a negative impact on the timely detection of failures of the controlled object. Also, a very negative factor is the complete absence of any forecast of the technical condition of the control object, which leads to sudden disconnections of the secondary power supply system of field communication facilities, and, accordingly, a break in communication. The combination of these factors has an extremely negative effect both on the stable operation of the communication system as a whole, and on the coefficient of serviceable operation of the communication direction, in particular. The purpose of the work is to develop methods for monitoring and predicting the technical condition of the secondary power supply system of field communication facilities. Methods used: the application of the neural network approach allows you to achieve very accurate results and get high performance systems in real time. The novelty of the work is to increase the accuracy and speed of control, the ability to predict the technical condition, the integration of the secondary power supply system into the information environment of the field communication object by using neural network technologies. Result: the application of the neural network approach allows you to predict the technical condition, as well as more accurately classify the technical condition of the control object. Also, it becomes possible to centralize control, which, in turn, reduces the control time. Practical significance: the results of the work can be used in the process of monitoring and predicting the technical condition of complex technical systems, which will significantly reduce the number of accidents.
UNAUTHORIZED INFORMATION RECOVERY CHANNEL MODEL
Authors:   Telecommunication military academy, Sinyuk A.D. , Ostroumov O.A. ,   Telecommunication military academy
Published: January 2023

Large amounts of information are stored in hard disk drives. In modern information systems. Deleting files using the operating system or reformatting the magnetic drive does not delete the data. There is an opportunity to recover the data by the violator in the conditions of moving the drive from the controlled premises for disposal, sending for repair, theft, replacement, substitution, donation, etc. The known information destruction methods are not always economical and do not fully meet the reliability requirement. The modern methods selection of information recovery is carried out. During the implementation of software methods for destroying information, the overwriting of the masking sequence above deleted information is carried out. This does not guarantee its destruction, because the motion path of the hard disk recording head does not exactly coincide with the magnetic track, and residual magnetization regions carrying information about previous records are formed at the edges. It is assumed that the intruder owns one of the most advanced high-resolution information recovery technologies for studying the areas of residual magnetization. The technology of magnetic scanning microscopy is proposed, which is closely associated with an increase in the recording density of information on storage devices. The carried out operating principles analysis of modern magnetic scanning microscopes made it possible to create conditions for the model development of an unauthorized information recovery channel that includes an information source representing the drive surface and the intruder’s equipment for access to residual information. A source with an intruder connects an information transmission channel, which is proposed to be described by a model of a binary symmetric channel without memory. The erroneous recovery probability estimates of deleted information block and the errors average number in an information block are given. The results can be recommended to specialists in the field of building subsystems to protect information from unauthorized access to information systems for the synthesis of an adequate model of the intruder, development and selection, as well as assessing the developed methods reliability for the confidential information destruction.