bluuebunny/crossref_metadata_2025 huggingface dataset:
BRIDGING THERAPY RESULTS IN PATIENTS WITH ACUTE CALCULOUS CHOLECYSTITIS AND CONCOMITANT ISCHEMIC HEART DISEASE
Authors: Dinets A.V. , Kondratenko S.O. , Markulan L.Yu. , Holinko V.M.
Published: April 2024

Introduction. Binding or bridging therapy (BT) suggests long-term administration of short acting anticoagulants (unfractionated heparin – UFH or low-molecular-weight heparin – LMWH) during preoperative preparation and early postoperative period in patients who had been receiving anticoagulation therapy (ACT) or anti-aggregation therapy (AAT) for a long time before surgery. The generalized data on the BT technique for urgent surgical interventions, particularly, in patients with acute calculous cholecystitis (ACH) and concomitant ischemic heart disease (IHD), is currently lacking. The aim of the work – to improve the BT technique in patients with ACH and IHD and to evaluate the results of its application.

Materials and methods. The study included 73 patients– 33 (45,2 %) women and 40 (54,8 %) men aged 57 to 81 years, on average 71,4 ± 0,7 years, who had received ACT or AAT before the hospitalization. All patients were admitted to hospital within 72 hours (from 6 to 65 hours) from the onset of the disease, on average 27.3 ± 1.5 hours. The catarrhal ACH occurred in 27 (37,0%) patients, phlegmonous – in 21 (28,8 %) patients, gangrenous – in 25 (34,2 %) patients. According to Tokyo Guidelines for the management of acute cholangitis and cholecystitis (TG13), 19 (26.0 %) patients had ACH I degree, 31 (42.5 %) patients– ACH II degree, 23 (31.5 %) patients – ACH III degree. There were 3 (4.1 %) patients with NYHA class I heart failure, 39 (53.4 %) patients with NYHA class II heart failure, 26 (35.6 %) patients with NYHA class III heart failure, and 5 (6.8 %) patients with NYHA class IV heart failure. The advanced tactics of bridging therapy was applied, which depended on several factors such as INR, aPTT, creatinine clearance, Lee-White’s bleeding time. The target points were the frequency of INR or bleeding time therapeutic range achieving, and the frequency of hemorrhagic complications.

Results and discussion. Immediately before surgery (laparoscopic cholecystectomy), the target (therapeutic) INR range >2 was obtained in 18 (90 %) patients among 20 patients who had previously received warfarin. Among them 2 (10.0 %) patients had INR in the range of 1.3-2.0, 12 (60.0%) patients had INR in the range of 2.1-3.0, and 6 (30.0 %) had INR >3.1. The target value of bleeding time >12 min was in 48 (90.6 %) patients among the patients (53 patients) who had received AAT earlier. The values of bleeding time in the range of 10-12 min were in 5 (9.4 %) patients, 12.1-14 min –in 42 (79.2 %) patients, >14 min – in 6 (11.3 %) patients. In general, INR and bleeding time values were within the therapeutic window in 65 (90.3 %) patients, and there was no patient with signs of hypercoagulation. In the postoperative period, the dynamics of INR and bleeding time values were similar and figured out at increase in the part of patients with INR 2.1-3.0 and bleeding time 12.1-14 min respectively.
ЧАСТОТА СТРЕСОВИХ ВИРАЗОК І ЇХ ЗАЛЕЖНІСТЬ ВІД КИСЛОТНОСТІ ШЛУНКОВОГО ВМІСТУ В ПЕРИОПЕРАЦІЙНИЙ ПЕРІОД У ДІТЕЙ
Authors: Iskra Lu.A. , Bilyaev A. V.
Published: April 2024

Operative intervention is a strong stress, which creates the prerequisites for both exacerbation of chronic inflammatory processes of the mucous membrane of the stomach and duodenum, and the development of ulcers I erosions in previously conditionally healthy individuals - the so-called “stress-induced changes”.

The article presents historical recollections of the study of the problem. Also data are given on the incidence of stress-induced changes in the mucous membrane of the upper gastrointestinal tract, both in patients in the intensive care unit in the presence of a critical condition, and in persons undergoing postoperative rehabilitation, according to the results of the world’s largest randomized research.

Widespread aspects of pathogenesis are highlighted - emphasis on the role of mechanisms of hypoperfusion of internal tissues and the state of acidity of gastric juice as the primary causes of stress-induced changes in the mucous membrane of the stomach. The most informative methods of examination for the detection of erosive-ulcerative changes of the mucous membrane of the digestive tract are presented. Also, the results of studies of various methods of prevention and treatment of changes in the mucous membrane of the upper gastrointestinal tract are presented.

The problem of stress-induced erosive-ulcerative changes in the mucous membrane of the stomach and duodenum for pediatric surgery for a long time was not paramount. However, with the development of operational technology of treatment, the emergence of new methods to expand the scope of surgical intervention, the relevance of the latter began to grow. In addition, a separate role should be attributed to the development of market relations and the formation of a modern system of financing medical and diagnostic process.
РЕГРЕСІЙНІ МОДЕЛІ ТРАНСВЕРЗАЛЬНИХ РОЗМІРІВ ВЕРХНЬОЇ Й НИЖНЬОЇ ЩЕЛЕПИ ТА САГІТАЛЬНИХ ХАРАКТЕРИСТИК ЗУБНОЇ ДУГИ У ДІВЧАТ-БРАХІЦЕФАЛІВ В ЗАЛЕЖНОСТІ ВІД ОСОБЛИВОСТЕЙ ОДОНТОМЕТРИЧНИХ І КЕФАЛОМЕТРИЧНИХ ПОКАЗНИКІВ
Authors: Marchenko A. V.
Published: April 2024

В статті описані і проаналізовані регресійні математичні моделі транзверзальних розмірів верхньої і нижньої щелепи та сагітальних характеристик зубної дуги в залежності від особливостей одонтомет- ричних і кефалометричних показників дівчат-брахіцефалів із ортогнатичним прикусом. Із 18 можливих лінійних розмірів необхідних для побудови коректної форми зубної дуги у дівчат-брахіцефалів з ортогнатичним прикусом в залежності від особливостей одонтометричних і кефалометричних показників побудовані усі 18 достовірних моделей (коефіцієнт детермінації від 0,803 до 0,934). До побудованих моделей із коефіцієнтом детермінації більше 0,6 більш часто входять розміри зубів (72,3 %, з яких 20,5 % приходиться верхні різці, 20,5 % - на нижні різці, 4,5 %- на верхні ікла, 11,6 % - на нижні ікла, 5,4 % - на верхні малі кутні зуби, 8,0 % - на нижні малі кутні зуби, 1,8 % - на верхні перші велики кутні зуби), ніж кефалометричні показники (27,7 %). Серед розмірів верхніх і нижніх різців, іклів, малих та перших великих кутніх зубів до моделей найбільш часто входять наступні показники: мезіодистальні розміри коронки зубів (17,9%, з яких 10,7% на верхній щелепі); довжина зубів (13,4%, з яких 5,4% на верхній щелепі); ширина дентинно-емалевої межі у мезіодистальному напрямку (11,6%, з яких 5,4 % на верхній щелепі); присінково- язикові розміри коронки зубів (10,7 %, з яких 4,5 % на верхній щелепі). Серед кефалометричних показників до моделей найбільш часто входить міжочноямкова ширина (3,6 %).
CLINICAL-ANAMNESTIC AND ECHOCARDIOGRAPHIC MARKERS OF NEONATAL SEPSIS AT DIFFERENT GESTATION AGE OF NEWBORN
Authors: Kretsu Natalia , Koloskova Olena , Bilous Tetiana
Published: April 2024

neonatal sepsis remains one of the leading causes of morbidity and mortality in the neonatal age. Theinvolvement of the myocardium in sepsis remains insufficiently studied, in particular in neonatology, where issues ofmyocardial dysfunction in neonatal generalized infection seem even more controversial, especially in neonatal sepsisat different gestational terms. Objective. To study specific clinical and anamnestic and echocardiographic parametersin infants depending on gestational age for optimization of the prognosis in neonatal sepsis. Material and researchmethods. To achieve this goal, we observed 57 newborns with a verified diagnosis of “Neonatal sepsis”. Group I (23patients – 40.3%) included newborns with a gestational age of 37-42 weeks, Group II – 34 premature infants (59.7%)with a gestation of up to 36 weeks. The latter group, depending on the gestational age, was divided into IIA subgroup,

which was formed by 21 prematurely born patients with NS with a gestational age of 32-36 weeks, and the IIB sub-group – 13 newborns born before 32 weeks of gestation. Research results. The analysis showed that the severity of the

impairment in the general condition of the examined newborns general condition was assessed as severe in 47.8% ofnewborns of group I, in 88.2% of cases in group II (PI: II <0.05), in 85.7% of representatives of subgroup IIA (PI:IIA <0.05) and in 92.3% of children of subgroup IIB (PI: IIB <0.001). It is shown that every third child (30.4%) ofgroup I, 67.6% of newborns of group II (PI: II <0.05), half (52.4%) of the representatives of subgroup IIA (PII: IIA<0.01) and all seriously ill patients (92.3%) of subgroup IIB (PI: IIB, IIA: IIB <0.05) required cardiopulmonaryresuscitation in the delivery room. Thus, in relation to full-term patients, the risk of this significant postnatal factorof emergency is likely to increase: for group II: OR - 4.77 (95% CI 2.63-8.68), RR - 2.17 (95% CI 1.57-3.0), AR =0.37; and for premature babies with a gestational age of less than 32 weeks (IIB subgroup), respectively: OR – 27.44(95% CI 11.73-64.19), RR – 7.55 (95% CI 5.58-10.21 ), AR – 0.65. The correlation analysis showed that in prematureinfants suffering from NS, the increase in the functional capacity of the left ventricular myocardium was associatedwith the female sex (for EF r = 0.94, P = 0.0001, for FS - r = 0, 94, P = 0.0001) and the number of days of inotropicsupport (for EF r = 0.68, P = 0.043, for FS - r = 0.71, P = 0.03). Conclusions. The analysis of echocardiographic

parameters in the group of premature infants revealed a direct correlation between the ejection fraction and cardio-vascular resuscitation immediately after birth (r = 0.64) and the duration of inotropic drugs (r = 0.68).
CLINICAL FEATURES OF ANXIETY DISORDER IN POST-COVID-19 SYNDROME AND FINDING OF ITS PREDICTORS
Authors: Boiko Dmytro
Published: April 2024

the article summarizes and describes clinical features of anxiety disorders in post-COVID-19 syn-drome. Mental and neurological disorders occupy a leading place in the structure of post-COVID syndrome. Recent

studies indicate an increase in the incidence of anxiety disorders in individuals with COVID-19. However, no clini-cal or laboratory features of the post-COVID anxiety disorders have been identified. Therefore, our study aimed to

describe the clinical features of anxiety disorders in the post-COVID period and to develop a mathematical prog-nostic model to identify potential predictors of post-COVID anxiety disorder. We conducted a case-control clinical

study, which included 145 males and females, which were divided into 2 groups, namely: group 1 - patients whobecame ill with COVID-19 during the last 6 months and group 2 - persons who were not ill with COVID-19 duringthe last 6 months. The clinical interview included the registration of symptoms of the debut and the time of the debutrelative to the episode of COVID-19. The Beck anxiety inventory was used for the assessment of the overall level ofanxiety. The State-trait anxiety inventory was used to assess state and trait anxiety. Statistical analysis of the datawas performed using the program EZR Statistics 1.54. Anxiety disorders during the first 6 months after COVID-19develop more often than those who have not had the disease in the last six months. Patients who had COVID-19in the last 5-24 weeks have an increased risk of anxiety disorders during this period and therefore require closemedical supervision and sufficient awareness of the likely symptoms. People with a post-COVID anxiety disorderreported the presence of autonomic symptoms, including excessive sweating and tachycardia, a feeling of inneremptiness, as well as circadian rhythm disorders in the form of difficulty falling asleep and waking up at the desiredtime. It should be noted that the overall frequency of detection of anxiety disorders in the post-COVID period isincreasing. It has been established that the risk of developing post-COVID disorder decreases with knowledge ofthe fact of contact with an infected person before the COVID onset and increases with a heightened level of prior

personal anxiety. Circadian rhythm disorders, in particular sleep phase shift and abnormal fatigue, may be predic-tors of post-COVID anxiety disorder.
ANALYSIS OF THE USE OF MOBILE APPLICATIONS BY FOREIGN AND UKRAINIAN PHARMACIES WITHIN THE CONCEPT OF HOLISTIC MARKETING
Authors: Sakhnatska Nataliia , Aliekperova Nataliia
Published: April 2024

digitalization of the pharmaceutical sector requires the use of modern marketing approaches to pro-vide pharmacies with quality and safe pharmaceutical care within the holistic concept of marketing management. A

promising direction of digital transformation of the retail market of medicines is the introduction of special mobileapplications in the activities of pharmacies, which become a safe and accessible platform for the sale of medicinesto the population.The main purpose of the study is to exercise the analysis of the features of pharmaceutical services provisionusing mobile applications to foreign and Ukrainian pharmacy chains.The study is based on the use of content analysis, analysis of electronic resources, system, and logical analysis,as well as of the modeling method.As the objects of the study, American pharmacy chains CVS Pharmacy and Walgreens, British Boots, and LloydsPharmacy were selected, as well as 10 pharmacy chains in Ukraine in terms of turnover in January-October 2020.It is revealed that the leading world leaders in the retail market of medicines have been using this digital tool

in their marketing activities for a long time. Unlike domestic pharmacies, applications of foreign pharmacies ad-ditionally provide such services as online registration for testing and vaccination against COVID-19, additional

opportunities for the visually impaired, drug disposal, and others. Among the studied Ukrainian pharmacy chainsby market share, only a half have mobile applications with various functions, among the most developed mobileapplications are “Like” from LLC “Apteka-Magnolia” (“Pharmacy-Magnolia”), “Pharmacy 911” and “AptekaDobroho Dnia” (“Good Afternoon Pharmacy”).An integrated model of a mobile application of a modern pharmacy has been developed, aimed at effective

interaction of all necessary functions to provide the population with high-quality, convenient, and available phar-maceutical care. Promising areas of further research are the justification of the feasibility of using certain functions

of mobile applications, as well as other digital tools, such as pharmacy websites, social media pages within theconcept of holistic marketing.The results of the study conducted may be useful to specialists in the pharmaceutical industry for use in practicalpharmacy.
NEW MYOKIN IRIZIN: PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL ROLE
Authors: Novoskoltcev A.
Published: April 2024

New mechanisms of influence of physical activity on the human body are investigated nowadays, one of which is secretion of peptide hormone irisin. After physical examinations PGC-1α is synthesized in muscles and stimulates expression of FNDC5 that after modification is secreted as irisin. The recent scientific researches show that irisin plays an important role in energy and metabolic processes in organism. The data about regulation of synthesis, main functions and mechanisms of action, clinical signification of hormone irisin in conditions of physical activity are covered in present review.
ПУХЛИНО-ІНФІЛЬТРУЮЧІ ЛІМФОЦИТИ У ТРИЧІ НЕГАТИВНОМУ РАКУ МОЛОЧНОЇ ЗАЛОЗИ: КОРЕЛЯЦІЙНИЙ АНАЛІЗ ВЛАСНИХ ДАНИХ ТА ОГЛЯД ЛІТЕРАТУРИ
Authors: Zakhartseva Liubov , Yanovytska Mariia
Published: April 2024

Стаття узагальнює дані та представляє власне дослідження щодо значення пухлино-інфільтруючих лімфоцитів як прогностичного фактору для карцином молочної залози, зокрема так званих тричі негативних карцином, які не мають рецепторів до естрогену, прогестерону та ампліфікації HER2\new. Ця група пухлин є гетерогенною та має нижчі показники загальної та безрецидивної виживаності, терапевтичні опції для даної групи пухлин обмежені порівняно з люмінальними та HER2-позитивними пухлинами. Саме тому тричі негативні пухлини молочної залози привертають увагу науковців, оскільки потребують більш індивідуалізованого підходу в лікуванні та пошуку додаткових прогностичних факторів. Метою дослідження є проведення кореляційного аналізу пухлино-інфільтруючих лімфоцитів з показниками виживаності, стадією захворювання та ступенем диференціювання тричі негативних пухлин , визначення найбільш «імуногенних» гістологічних підгруп тричі негативного раку молочної залози, а також порівняння показника пухлино-інфільтруючих лімфоцитів як безперервного та за розподілом на групи. У дослідженні були використані зразки пацієнтів (n=143), що проходили лікування у Київському міському клінічному онкологічному центрі протягом 2010-2015рр, та яким вперше було встановлено діагноз раку молочної залози, який не має рецепторів до естрогену, прогестерону та ампліфікації HER2\new. Оцінка кількості пухлино-інфільтруючих лімфоцитів проводилась на гістологічних скельцях ретроспективно, за рекомендаціями міжнародної групи з визначення імунно-онкологічних біомаркерів. Кількість пухлино-інфільтруючих лімфоцитів була оцінена як безперервна величина, а також розподілена на групи А (0-10%), В (10-40%) та С (40-90%). За результатами дослідження було визначено наявність високої прямої кореляції між безперервним показником пухлино-інфільтруючих лімфоцитів та показником, розподіленим за групами (A,B,C). Було виявлено слабкий прямий кореляційний зв’язок між показником пухлино-інфільтруючих лімфоцитів та ступенем диференціювання пухлини, слабкий обернений кореляційний зв’язок між кількістю пухлино-інфільтруючих лімфоцитів та загальною виживаністю та стадією захворювання, зокрема розміром пухлини. Показник пухлино-інфільтруючих лімфоцитів для всіх карцином з медулярними характеристиками склав 100%, що вказує на високу «імуногенність» даного гістологічного підтипу пухлин. Дослідження підтверджує, що пухлино-інфільтруючі лімфоцити виступають у якості додаткового прогностичного маркера для злоякісних пухлин молочної залози, зокрема, тричі негативних. Визначення кількості пухлино-інфільтруючих лімфоцитів є доцільним у рутинній практиці патологоанатома під час дослідження злоякісних пухлин молочної залози, оскільки не потребує додаткових реакцій та є економічно обґрунтованим. Доцільним є використання рекомендацій міжнародної групи з визначення імунно-онкологічних біомаркерів щодо розподілу цього показника за групами А,В,С для зручності опису.
PARAMETERS OF OXIDATIVE HOMEOSTASIS IN CHILDREN WITH TYPE 1 DIABETES DEPENDING ON DURATION OF THE DISEASE AND COMPLICATIONS
Authors: Shevchenko T. , Maidannyk V.G.
Published: April 2024

The increase in the number of endocrine pathology in our time is most associated with the prevalence of diabetes mellitus, which is one of the medical and social problems of modern society. According to the International Diabetic Federation (IDF) in 2015, about 415 million people in the world suffer from diabetes mellitus (DM). The purpose of our work is to study the parameters of oxidative homeostasis in children with type 1 diabetes, depending on the duration of the disease and the late complications of type 1 diabetes.

Methods and materials. A total of 90 children with type 1 diabetes mellitus were diagnosed with age 13.59 ± 1.04 grams, 42 of them were girls and 48 boys with a disease duration of 4.68–3.49 grams. All children underwent treatment at the endocrinology department at the DKL No. 6, Kyiv. In the children we examined, we studied the indexes of oxidative homeostasis, namely, the products of LPO – MDA were de- termined according to the method of Stalin ID, the antioxidant system – SOD was determined according to the technique of Siroty T.V., catalase by the method of Korolyuk M.A., and reducing glutathione – by the method of Hymerha F.I. The research was conducted at the Research Institute of Experimental and Clinical Medicine of the O.O. Bogomolets NMU.

Result. We detected a reliable dependence of the level of malondialdehyde on the duration of type 1 diabetes mellitus. The level of malondialdehyde increased with an increase in the duration of DM 1 type. The level of SOD the first years of the disease increased, but for 5 years the disease was reduced. The level of catalase and glutathione with decreasing durability decreases. What can be said about the depletion of the AOS and the maintenance of OS performance at a high level. There was no reliable dependence on the presence of late complications and the level of indicators of oxidative homeostasis.
EFFECT OF POTENTIAL MEDICINAL PRODUCT ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITY ON THE FATTY-ACIDIC COMPOSITION OF THE VAGINE TISSUE AND BLOOD SERUM OF RATS WITH EXPERIMENTAL VAGINITIS
Authors: Onyshchuk L.V.
Published: April 2024

The purpose of the study was to investigate the effect of a potential combined drug with antimicrobial and antiinflammatory activity on the fatty acid composition of lipids in vaginal tissue and blood serum of rats with simulated vaginitis.

Materials and methods. The study was conducted on 35 female rats of the Vistar line weighing 180-220 g. Animals were divided into 5 groups: 1 – intact animals, control; 2 –animals with simulated traumatic vaginitis (TV); 3 – TV + base for suppository; 4 – TV + study drug with antiinflammatory and antimicrobial activity in the form of vaginal suppository; 5 – TV + comparative product Neo-Penotran® (“Ekselstix Helske SL”, Spain) in the form of a vaginal suppository. The study drug contained ibuprofen, clotrimazole and metronidazole in the form of suppositories. Composition Neo-Penotran® contains miconazole and metronidazole. Basis of the both medicines was the same – Vitepsol. Determination of the fatty acid composition of lipids in the tissues of the vagina and serum was carried out using the gas chromatography method.

The results revealed 9 of the most informative fatty acids: of them meristic C14:0, pentodecan C15:0, palmitinic C16:0, stearic C18:0 related to saturated fatty acids (SFAs), and oleinic C18:1, linoleic C18:2, linolenic C18:3, arachidonic C20:4, which is the sum of unsaturated fatty acids (UFAs). Linoleic C18:2, linolenic C18:3, arachidone C20:4 LC are part of polyunsaturated fatty acids (PUFAs) and are characterized as essential.

Conclusions. The study results showed that there is a change in the total content of SFA, UFA and PUFA in the background of traumatic vaginitis: SFAs – 44.5%, UFA – 55.5% and PUFA – 31.9% versus 50.4%, 49.6% and 27.5% of lipids in the vaginal tissue in the control group. It was found that after administration of the study drug against the background of traumatic vaginitis, the normalization of the SFA ratio was 37.8%, the UFA 62.2%, and the PUFA – 44.4% compared to 43.3%, 56.7% and 35.4% serum lipids in the control pathology.
CLINICAL AND EFFECTIVE RISKS OF DISABILITY AMONG VICTIMS OF ROAD TRAFFIC ACCIDENTS
Authors: Guryev S.O. , Yaroviy D.M.
Published: April 2024

Clinical and effective risks of disability incidence have been determined on the basis of analysis of 219 cases among the victims of road accidents that have suffered from disability. Determination of the clinical outcome of the risk of invalidity among the victims as a result of traffic accidents is an important stage in the development of a comprehensive rehabilitation system aimed at reducing the level and degree of disability among the victims as a result of road traffic accidents. The highest risks are male, age group of which is 46-75, and pedestrians who have been injured with combined trauma mechanisms. The highest risks are the clinic-anatomical groups of the limbs and the backbone, the clinical and nosological groups “KTAST”, “KST”, “KATAT” and the damage, assessed on the scale of ISS from 25 to 75 points. It is necessary and appropriate to adhere to the principle of individualizing the choice and carrying out rehabilitation activities, depending not only on the clinical and nosological characteristics of the injury, but also on the level of the risk of incidence of disability. The peculiarity of the rehabilitation of victims as a result of an accident is the beginning of the rehabilitation process from the stage of unstable adaptation and the need to ensure the continuity of the implementation of rehabilitation measures.
PROBLEMS AND WAYS TO IMPROVE THE ORGANIZATION OF CARDIOLOGICAL CARE TO THE RURAL POPULATION, IN THE CARDIOLOGISTS OPINION
Authors: Ivanyuk Anatoliy , Kanyura Alexander
Published: April 2024

to study the state, problems and ways of improving the organization of cardialogical care for the rural population in Ukraine based on the materials of a sociological survey of cardiologists.
HYGIENIC SUBSTANTIATION OF A NEW PESTICIDES IN UKRAINE OXATHIAPIPROLIN AND FLUFENACET MAXIMUM ALLOWABLE CONCENTRATION IN THE WATER BODIES USED FOR HOUSEHOLD AND DOMESTIC WATER SUPPLY
Authors: Novokhatska O.O. , Vavrinevych O.P. , Zinchenko T.I. , Syrota A.I.
Published: April 2024

To prevent and decrease negative impact of pesticides on population health, safe levels of its residues in the water should be substantiated. Taking into consideration the fact of absence of regulations in the water of ponds in Ukraine for such substances as oxathiapiprolin and flufenacet, the purpose of the work was hygienic substantiation of this new pesticides in Ukraine maximum allowable concentrations in the water of water bodies used for household and domestic water supply.

Taking into account the abovementioned, we have performed experimental studies to substantiate the hygienic standard of studied pesticides in the water using physical- chemical, organoleptic, photometric, chromatographic, and statistical analysis methods. As a result of experimental studies threshold concentrations of oxathiapiprolin and flufenacet were established by the influence: on organoleptic properties of water at the level of 0.02 mg/dm3 and 0.2 mg/dm3, on the general sanitary regimen of pond – 0.0002 mg/dm3 and 0.002 mg/dm3, and on sanitary-toxicological index of hazard – 0.2 mg/dm3 and 0.02 mg/dm3, correspondingly. The findings allowed us to establish a limiting index of hazard (general sanitary) and to substantiate scientific evidence-based MAC of oxathiapiprolin in the water at the level of 0.0002 mg/dm3 and flufenacet – 0.002 mg/dm3.
THE SIGNIFICANCE OF LIPID METABOLISM DISORDERS IN THE BLOOD AND SKIN OF PATIENTS WITH PSORIASIS IN THE PATHOGENESIS OF DERMATOSIS
Authors: Ghazi Alkammaz Ali Mohammed
Published: April 2024

The etiology of psoriasis continues to remain unsettled, and issues of the pathogenesis of this dermatosis are also not fully resolved. The analysis of lipid metabolism disorders in the blood and skin of patients with psoriasis, established at the present stage, indicates their importance in the pathogenesis of this dermatosis. At the same time, taking into account the wave-like recurrent course of psoriasis and the existence of autumn-winter, spring-summer and offseason (mixed) types of dermatosis, there remain unsolved questions of the influence of the features of lipid spectrum indexes in the body of psoriasis patients in the development of clinical exacerbations of dermatosis in different seasons of the year. Uncertainty is also the possibility of a correlation relationship between the degree and nature of imbalance in the level of the lipid spectrum in the blood and skin of patients with psoriasis with the severity of the clinical course of dermatosis. Further in-depth study of lipid metabolism in the body of patients with psoriasis involving new immunopathohistochemical techniques will contribute to the development of an improved complex individualized therapy and broadening the understanding of the pathogenesis of this dermatosis.
DEVELOPMENT OF THE CONTROL SYSTEM REGARDING THE SPREAD OF INFECTIOUS DISEASES IN THE RUSSIAN EMPIRE BE-FORE THE TWENTIETH CENTURY
Authors: Hrynzovskyi Anatolii
Published: April 2024

None of the areas of medicine has so far managed to save as many lives as epidemiology, namely immunoprophylaxis. The history of immunoprophylaxis dates back many centuries, but as a specialized scientific and medical field dates back to May 14, 1796. It was on this day that the English physician Edward Anthony Jenner began to practice vaccinations against smallpox.
Book2. Building an ecosystem and infrastructure for smart confectionery production
Authors: Shchurenko Anastasiia
Published: April 2024

Innovative transformation operational and operational characteristics of the ecosystem and infrastructure of a smart confectionery production facility into a developed combined supersystem with interconnected subsystems for online monitoring and control in real time, including for energy supply and water treatment modules. The importance of applying the principles of innovative design, manufacturing and operation of the entire complex and ecosystem components of the infrastructure of a smart confectionery production facility in the formation of an integrated system for the regeneration and recycling of wastewater and other environmental resources with the introduction of innovative technological production relaxation systems into sets of technological equipment and equipment, in turn included in autonomous ecosystems and infrastructures of special technological equipment, as well as ecosystems and infrastructures of special technological equipment, as well as smart production, office and warehouse premises. Features of current standards, conditions and requirements for creating elements Features of the current standards, conditions and requirements for creating design elements of a smart infrastructure complex and ecosystem of a smart object design of a smart infrastructure complex and ecosystem of a smart confectionery production facility and special technological equipment, taking into account confectionery production and special technological equipment, taking into account the solution he solutions online in real time monitoring and control tasks, as well as real-time monitoring and control tasks, as well as partial energy supply through the use of solar energy and, in addition, partial energy supply through the use of solar energy, and in addition, the creation of conditions and characteristics that allow the use of visual stabilizers to create conditions and characteristics that allow the use of visual stabilizers of the psychological and psychological climate in production systems and premises of the startup climate in production systems and premises of startups.
PENANAMAN NILAI-NILAI MULTIKULTURAL MELALUI PENDIDIKAN AGAMA ISLAM DI SEKOLAH MENENGAH PERTAMA PGRI 2 LAWANG
Authors: Cindy Ika Saraswati  , Moh. Mansur Fauzi
Published: April 2024

Indonesia is a pluralistic country because its own citizens consist of a variety of ethnicities, religions, languages, cultures, and different beliefs because of the many diversities that often many conflicts occur. So religious education is needed to create an attitude of tolerance, respect, and understanding. SMP PGRI 2 Lawang is a public educational institution with a lot of diversity in its students. For this reason, Islamic Religious Education is needed to foster multicultural values. This research aims to find out the multicultural values at SMP PGRI 2 Lawang through Islamic Religious Education and to find out the supporting and inhibiting conditions for the cultivation of multicultural values at SMP PGRI 2 Lawang through Islamic Religious Education. Qualitative research is the method used in this study. In collecting data, researchers used observation, interviews, and documentation. In analyzing the data, researchers used data reduction, data presentation, and conclusion. Testing the validity of the research data, researchers used triangulation and extended observation.
PENGARUH PENGGUNAAN MODEL PEMBELAJARAN DISCOVERY LEARNING TERHADAP PENINGKATAN HASIL BELAJAR SISWA PADA MATA PELAJARAN FIQIH DI MTS AHMAD YANI JABUNG
Authors: Irna Nur Solikah  , Imam Athoir Rokhman
Published: April 2024

One of the problems found at MTs Ahmad Yani Jabung is the lack of understanding and ability of students in understanding Islamic Religious Education lessons, especially zakat material. One of the proposed models is discovery learning, which is known to train students' abilities in critical, analytical, and creative thinking.
The purpose of this research is to know: (1) to know the effect of the discovery learning model on improving student learning outcomes in fiqh material at MTS Ahmad Yani Jabung. (2) to know the students' response to the discovery learning learning model.
The research method used is a quantitative approach with the type of quasi-experimental design using two classes, the first class using the lecture model and the second class using the discovery learning model on the same material using tests.
The results showed that the use of discovery learning model has a significant effect on students' learning outcomes in zakat material. Through paired t-test between pre-test and post-test in the experimental class, it was found that the significance value (2-tailed) was 0.000, smaller than 0.05, which indicated a significant difference between students' learning outcomes before and after using the discovery learning model. This confirms the positive influence of this learning model on students' understanding of fiqh material. In addition, students' responses to the discovery learning model were also positive, with a high percentage of satisfaction, indicating that students at MTs Ahmad Yani Jabung liked the use of this learning model.
HUBUNGAN ANTARA LITERASI DIGITAL DENGAN KEMANDIRIAN BELAJAR BIOLOGI PESERTA DIDIK DITINJAU DARI JENIS KELAMINNYA
Authors: Debitama Hanif , Muhammad Khalifah Mustami  , Ahmad Ali
Published: April 2024

Digitalisasi telah merambah dunia pendidikan saat ini, menambah pentingnya peserta didik untuk menguasai keterampilan literasi digital. Keterampilan tersebut dapat memicu kemandirian  peserta didik untuk memanfaatkan perangkat digital untuk mencari informasi edukatif yang dibutuhkan. Penelitian ini bertujuan untuk mengetahui hubungan antara literasi digital dengan kemandirian belajar biologi peserta didik kelas XI MA Madani Alauddin Pao-Pao ditinjau dari jenis kelaminnya. Jenis penelitian ini merupakan ex-post facto dengan desain penelitian korelasional tipe explanatory design. Populasi pada penelitian ini berjumlah 121 peserta didik. Sampel yang digunakan sebanyak 55 peserta didik yang diperoleh dengan menggunakan teknik  probability sampling tipe simple random sampling. Instrumen yang digunakan adalah kuesioner untuk mengumpulkan data literasi digital dan kemandirian belajar peserta didik. Teknik analisis data menggunakan uji korelasi product moment. Hasil penelitian yang diperoleh menunjukkan bahwa gambaran literasi digital peserta didik ditinjau dari jenis kelamin masing-masing tergolong tinggi yang dibuktikan dari nilai mean, yaitu 78,36 (laki-laki) dan 81,40 (perempuan). Begitupun gambaran kemandirian belajar peserta didik ditinjau dari jenis kelamin juga tergolong tinggi dengan nilai mean, yaitu 88,96 (laki-laki) dan 90,17 (perempuan). Selanjutnya, literasi digital dengan kemandirian belajar memiliki hubungan yang positif dan signifikan yang dapat dilihat dari nilai sig. α = 0,000<0,05 serta rhitung = 0,532 > rtabel = 0,2656.
Pengaruh Return On Asset , Corporate social Responbility dan Capital Intensity terhadap Tax Avoidaice
Authors: Prasetya Dionisius Andra Anggara , Susilowati Clara
Published: April 2024

Penelitian ini bertujuan untuk menguji pengaruh Return On Assets (ROA), Corporate Social Responbility dan Intensitas Modal pada Penghindaran Pajak. Penelitian ini dilakukan pada perusahaan manufaktur dan Perusahaan perbankan di Bursa Efek Indonesia (BEI) pada tahun 2017-2022. Itu data diperoleh dengan mengakses laman Bursa Efek Indonesia. Pengujian hipotesis menggunakan analisis regresi berganda dengan menggunakan SPSS 24.Hasil uji regresi menunjukkan bahwa Return On Asset, Corporate Socal Responbility, dan Capital Intensitas berpengaruh terhadap Penghindaran Pajak. Keterbatasan penelitian ini adalah bahwa hal itu terletak pada masa observasi dan keterbatasan data Corporate Social Responbility dikarenakan Sebagian Perusahaan manufaktur tidak menerbitkan Corporate Social Responbility.  sehingga membuka peluang untuk selanjutnya peneliti untuk melakukan penelitian lebih lanjut dengan menambahkan periode pengamatan dan menambah sampel .Implikasi dari penelitian ini adalah meningkatkan pengetahuan dasar mengenai penghindaran pajak yang dapat dilakukan dipengaruhi oleh Return On Asset yang diproksikan menggunakan Return On Assets (ROA) dan Corporate Social Responbility diproksikan dengan menggunakan Rasio Corporate Social Responbility (GRI Index), sedangkan Intensitas Modal dalam penelitian ini menggunakan Rasio Intensitas Aktiva Tetap.
FACTORS AFFECTING TAX REVENUE AT KPP PRATAMA TERNATE CITY
Authors: Fala Dwi Yana Amalia Sari , Meliana Meliana
Published: April 2024

Taxes have an important role in the life of the country and the implementation of development. Tax revenues are very much needed for this. Revenue that does not meet the target will certainly be an obstacle in the country's development process. The purpose of this research is to determine and analyze the influence of E-Commerce Transactions, Tax Audits, Information Technology, Account Representative Professionalism and E-Tax Applications on Tax Revenue at KPP Pratama Ternate City. The population in this study are individual taxpayers registered at KPP Pratama Ternate City. The sampling method used was simple random sampling. with a total sample of 399 respondents and using primary data. The test tool used is partial linear regression analysis (Partial Least Square/PLS). The research results show that e-commerce transactions have no effect on tax revenues. Meanwhile, audits, information technology, professionalism of account representatives and e-tax applications influence tax revenues.
ANALISIS AKUNTANSI PEMILU DALAM PELAPORAN DANA KAMPANYE GUNA MEMINIMALISIR POTENSI SALAH SAJI
Authors: Dianawati Dianawati , Yani Ahmad , Selviasari Rike
Published: April 2024

Pemilihan umum (pemilu) 2024 ditetapkan pada 14 Februari 2024, setiap peserta pemilu memerlukan dana kampanye dan wajib melaporkan dana kampanye ke KPU sebagai pertanggungjawaban peserta pemilu. Tujuan dari penelitian ini adalah menganalisis penerapan akuntansi pemilu terkait pengakuan, penyajian, dan pengungkapan dalam pelaporan dana kampanye sekaligus sebagai kebaruan penelitian. Lokasi penelitian dilakukan pada DPD Partai PERINDO Kabupaten Kediri. Jenis penelitian ini adalah deskriptif kualitatif dengan sumber data transaksi laporan awal dana kampanye (LADK) periode 2023-2024. Teknik pengumpulan data diperoleh dari wawancara dan dokumentasi. Teknik analisis data yang digunakan yaitu pengumpulan data, reduksi data, penyajian data, penarikan kesimpulan dan verifikasi. Hasil penelitian menunjukkan bahwa DPD Partai PERINDO Kabupaten Kediri belum menerapkan akuntansi pemilu yang sesuai dengan PKPU No.18 Tahun 2023 Tentang Dana Kampanye Pemilihan Umum dan Keputusan KPU No.1677 Tahun 2023 Tentang Pedoman Teknis Pelaporan Dana Kampanye Pemilihan Umum. Pengakuan, penyajian, dan pengungkapan transaksi LADK periode 2023-2024 masih belum sesuai standar yang berlaku karena kurangnya kompetensi SDM.
PENGARUH MORAL PAJAK, PERSEPSI KEADILAN PAJAK, PENGETAHUAN PAJAK TERHADAP INTENSI KEPATUHAN PAJAK
Authors: Sihombing Deborah W. G. , Nuryanah Siti
Published: April 2024

Belum optimalnya tax to GDP ratio Indonesia mengindikasikan masih rendahnya kepatuhan pajak. Oleh karena itu, upaya peningkatan kepatuhan pajak harus dilakukan kepada masyarakat dimulai sejak dini, salah satunya kepada generasi muda yang merupakan calon wajib pajak di masa depan. Penelitian ini bertujuan untuk meneliti pengaruh moral pajak (tax morals), persepsi keadilan pajak (perception of tax fairness), dan pengetahuan pajak (tax knowledge) terhadap intensi kepatuhan pajak mahasiswa sebagai generasi muda yang merupakan bagian dari wajib pajak potensial. Metode yang digunakan adalah metode kuantitatif dan data yang digunakan merupakan data primer yang diperoleh melalui kuesioner. Berdasarkan survey dari 116 responden yang terkumpul dengan convenience sampling, hasil penelitian menunjukkan mahasiswa yang memiliki moral pajak yang tinggi akan memiliki intensi untuk berlaku patuh melaksanakan kewajiban perpajakannya, begitu pula mahasiswa yang memiliki persepsi keadilan pajak, dan pengetahuan pajak yang tinggi. Penelitian ini membuktikan bahwa terdapat pengaruh moral pajak, persepsi keadilan pajak, dan pengetahuan pajak terhadap intensi kepatuhan pajak mahasiswa.
SafeRouteGuard : Accident-Aware Navigation System
Authors: Garande Anuja Garande , Kondhalkar Omkar , Sherigar Ayush , Rathod Pranav , Gadhave Manish
Published: April 2024

SaferRouteGuard is a novel web application designed to enhance road safety by providing real-time notifications of accident- prone zones, or "black spots," along user-input routes. This system aims to reduce the likelihood of accidents and enhance overall road safety. The research paper discusses the development, methodology, data sources, and future scope of SaferRouteGuard. In a world where transportation is a vital part of our daily lives, road safety remains a paramount concern. The alarming frequency of road accidents, their devastating consequences, and the associated economic burden demand innovative solutions that can proactively address this issue. We are proud to present a groundbreaking project that brings together technology, data analysis, and real-world impact in the form of the "Road Accident Navigation System and Minimal Accident Route Recommendation.”
The Effect of Fenugreek Paste on Physical Quality and Organoleptic Quality Meatballs Made From Chicken Meat
Authors: Nur Laila  , Patriani Peni , Trisna Ade
Published: April 2024

Meatballs is a processed meat product and one of Indonesia's favourite culinary delights. This study aims to determine the effect of fenugreek paste on the physical and organoleptic quality of meatballs made from chicken meat. The research was conducted in June-July 2023 at the Research and Technology Laboratory, Faculty of Agriculture, and Animal Production Laboratory, Faculty of Agriculture, University of No Sumatra. The design used in this study was RAL (Completely Randomised Design) with 4 treatments, namely P0 = 0%, P1 = 5%, P2 = 10%, P315%, and 5 replications. The parameters    in this study were physical quality tests, namely meatball pH and cooking loss, and organoleptic tests of color, aroma, taste, and tenderness. The results showed that 5%, 10%, 15% fenugreek paste had a very significant effect (P<0.01) on physical quality and organoleptic quality. The higher the percentage of fenugreek paste used in meatballs, the higher the physical and organoleptic quality of meatballs In conclusion of this study is that fenugreek is good to add to get quality meatballs
The Problematics of Turning on The Main Light Lettings For Two-Wheeled Motor Vehicle Under The Laws Number 22 Year 2009 on Traffic And Road Transport
Authors: Prihartini Juliani , Syahrin Alvi , Mulyadi Mahmud , Marlina
Published: April 2024

For two-wheeled vehicles, it is expressly required by Law Number 22 of 2009 Concerning Road Traffic and Transportation to switch on the primary lights during the day. A requirement for vehicle eligibility on the road is the regulation of this obligation. The provisions in the UULLAJ do not yet control the ATPM's accountability for vehicle requirements that ensure the headlights stay on and the availability of an automatic device as a warning when the headlights are damaged. This has ramifications for traffic-related duties performed by the National Police in the area of law enforcement. Only drivers who fail to fulfil their requirements to ensure the specifications of their primary lights throughout the day without touching the ATPM are the targets of law enforcement. Because there was no legal framework for the Police to take action against the ATPM, this law enforcement was not carried out. In reality, considerations of legal certainty, justice, and advantages must be given while establishing a legal norm. Data were collected using interviews as main sources and library research as secondary sources. This study employs a qualitative research methodology and is a descriptive analysis.
The Interview: Citra Politik Kim Jong Un Dalam Hegemoni Film Amerika
Authors: Nasution Faiz Albar , Indainanto Yofiendi Indah , Muhammad Ardian  , Saraan Muhammad Imanuddin Kandias
Published: April 2024

This study examines film The Interview to determine hegemonic process of political power relations in American films. North Korea is known as a closed country that strongly opposes western domination, especially America. Foreign media always describe North Korean government as a dictator, meaning absolute power of leader. In contrast, film The Interview depicts a humorous figure of North Korean leader by showing figure of Kim Jong Un who enjoys American culture. The plot of Twits in this film depicts uprising that took place to make North Korea a democracy. Qualitative descriptive research method is used in analyzing film through approach of Gramsci hegemony theory about how hegemony process in the film The Interview. Data collection techniques through literature examination include books, journals, documents, and films. Data reduction, data visualization, and drawing conclusions are data analysis activities. The results of study show that dominant group tries to exert influence with concepts of mastery in a persuasive manner by presenting reality from a different point of view. The dominant people here are Americans who are trying to change mindset audience by seeing North Korea as an oppressed people. Leaders who have been known to be assertive, such as Kim Jong Un, who is feared by people, are portrayed as humorous figures with a love for American culture, which is a clear fact in their development that they often experience political tensions.
Kebebasan Politik Menurut Hannah Arendt dan Relevansinya Bagi Masyarakat Indonesia
Authors: Ranubaya Fransesco , Nikodemus  , Endi Yohanes
Published: April 2024

The study focuses on freedom and politics, which are often contrasted, as if politics and freedom are contradictory. There is an assumption that there is no freedom in politics or that people are free to do anything with politics. This assumption has developed so that the two can never be united. In the political situation, a political theorist named Hannah Arendt felt an anxiety. The purpose of writing this scientific paper is to explore the idea of political freedom according to Hannah Arendt and find its relationship in Indonesian society. The method used in this writing is the literature method with a literature approach. The research results of this study discuss work that is not related to daily activities (labor) but work (work) for a common goal. Meanwhile, in relation to Indonesian politics, work ethic is an attitude that leads to the best results, high competitiveness, optimism and looking for productive and innovative ways to sustain an independent Indonesia. Regarding freedom, Arendt takes the Athenian polis as a model of communicative and open speech space which is the same as politics