bluuebunny/crossref_metadata_2025 huggingface dataset:
The role and importance of physical exercise in the prevention of cardiovascular disease
Authors: Neamtu A.C. , Amaricai E.C. , Ghircau Radu R. , Olariu I. , Lintini T.R. , Olariu T. , Iurciuc S.
Published: November 2024

Cardiovascular disease (CVD) is the leading health problem of the modern world. They are the leading cause of death in both developed and transition countries. Physical activity (PA) has a beneficial impact on the cardiovascular system, both directly by improving endothelial function and indirectly by normalising atherosclerosis risk factors such as dyslipidaemia, hypertension, obesity and through positive effects on the clotting mechanism. The impact of physical activities on the cardiovascular system is manifested by immediate changes in hemodynamics, blood pressure and heart rate during physical training. After sustained physical training basal heart rate, blood pressure and heart rate response to physical activity stress decrease, indicating good conditioning through increased physical capacity. Prospective epidemiological studies have shown that a sedentary lifestyle has a two-fold increased risk of sudden death and cardiovascular mortality. Physical activity needs to be ongoing to have positive effects on the cardiovascular system; that means 4 to 5 times a week depending on the duration and intensity of exercise. Physical activity in patients with coronary heart disease should be individualised, quantified and monitored. In subjects with impaired heart muscle function, physical activity is limited with characteristic symptoms - dyspnoea and stenocardia. These patients are classified into mild, moderate and high risk groups and based on this the allowable intensity of their physical activity is assessed, as well as the degree of its control. Exercise should be range free and should not exceed this symptom limit. The aim of physical activity and training is to increase the symptom tolerance threshold.
Factors influencing the postoperative evolution of patients underwent total hip arthroplasty
Authors: Bontea M.G. , Bimbo-Szuhai E. , Macovei I.C. , Maghiar A.M. , Moga I.
Published: November 2024

This study aimed to explore the preoperative risk factors related to blood transfusion after hip arthroplasty and the benefits of anterior approach over the traditional lateral approach and to determine the influence of selected factors on the intensity of postoperative pain after hip total hip arthroplasty. Methods: Patients underwent preanesthetic assessment, checking preoperative hemoglobin (Hgb) levels and reassessing on the first and second postoperative days. We also controlled postoperative pain according to our pain control protocol to track opioid need at 6, 12, 24, 48, 96 hours after hip arthroplasty. Results: Risk factors affecting postoperative blood transfusion were highly correlated with preoperative Hgb level. In anterior approach the needed quantities of opioids is lower.
Evaluation of the oral health values in a group of adults
Authors: Dumitrache M.A. , Moanţă E.A. , Cărămidă M. , Sinescu R. , Himcinschi M.E. , Funieru C. , Sfeatcu R.
Published: November 2024

This study aims to put into perspective the attitudes and oral health values of a defined population group from Romania, in connection with their dental habits. By using a set of closed questions, the individuals participating to the study were able to give a glimpse into the general psychology behind most of their decisions regarding oral health. The paper comes to provide valuable information regarding the difference between the oral health values of the studies subjects from different groups of environment, educational levels, sex, age, and work field. The results showed that the most favourable populational group to have a high oral health values and sanogenic behaviour is correlated with the feminine sex, high educational level, urban environment, medical work field, and not so much with age, as the results state a clear non-difference age dependant.
Oral health related behaviour among dental students – a comparative study
Authors: Sfeatcu R. , Dumitrache M.A. , Mihai C. , Dumitrașcu L.C. , Tănase M. , Funieru C.
Published: November 2024

The aim of the present study was to compare the oral health behavior of first year students with that of sixth year students from Faculty of Dentistry, University of Medicine and Pharmacy “Carol Davila”, in Bucharest. A descriptive cross-sectional study was carried out on 293 undergraduates, divided into 2 groups: 156 students from the first year and 137 from the sixth year. The method used was the sociological survey based on an anonymous self-administered questionnaire. The results showed an unhealthy behaviour among first-year students and a correct one regarding oral hygiene, but also incorrect in other respects (dental attendance, diet with low consumption of fruits and vegetables, but frequent consumption of cariogenic foods, and smoking status). The oral health behaviors reflect the importance of the speciality knowledge accumulated during the years of study. The knowledge and habits of dental students are an important part of professional education.
Treatment approaches for maxillary sinus cysts
Authors: Vasca E. , Riviș M. , Popovici R.A. , Fluieras R. , Nica D. , Chioran D. , Todor S.A. , Domocoș D.
Published: November 2024

Maxillary sinus cysts are frequently asymptomatic and are often discovered accidentally on radiographs. Panoramic radiography and plain radiography of the skull can be used in routine practice to highlight these cysts, which usually appear as rounded, dome-shaped masses located on the floor of the maxillary sinus. Computed tomography (CT) should be used to determine their dimensions or relationship to neighboring anatomical structures. Treatment of maxillary sinus cysts is consistent with their size, location, pathology and potential for recurrence. Interdisciplinary treatment planning is important in its long-term success. The following surgical methods are described as treatment methods: marsupialization, enucleation or radical cure (extirpation of the cystic membrane) and radical cure by the rhinological method and as an exceptional, sometimes transient method, the drainage of the cystic content through a polyethylene tube.
Clinical management of inverted mesiodens – case report
Authors: Luca M. , Nikolajevic-Stoican N. , Balog C. , Buzatu R. , Popa M. , Urechescu H. , Matichescu A.
Published: November 2024

Mesiodens is a common developmental anomaly characterized by the presence of one or more supernumerary teeth in the maxillary midline region. However, inverted mesiodens, where the tooth crown points towards the nasal cavity, is a rare variation of this condition. This paper aims to present a case study of a 7 years old male patient with inverted mesiodens and aspects of treatment, successful management and aetiology of this unique dental anomaly.
Efficacy of Goccles medical device in the screening of potentially malignant oral lesions- an experimental study
Authors: Rusu L.C. , Roi A. , Muntean I. , Grecu A. , Lupean B. , Roi C.I. , Soanca A. , Rivis M.
Published: November 2024

Oral cancer is characterized by the abnormal growth of cells that can invade any part of the mouth, including the gums, tongue, hard palate, and soft palate. GOCCLES® uses autofluorescence technology to aid in the early detection of oral cancer lesions. This non-invasive screening method is more effective than visual inspections and can detect even the slightest tissue changes. While traditional white lights decrease the dentist's ability to identify affected areas, GOCCLES® allows them to see subtle changes in intense fluorescent green light. With such advanced technology, dentists can more efficiently diagnose oral lesions at the first signs, thereby increasing the chances of successful treatment. Additionally, GOCCLES® can be used as a monitoring tool to ensure that patients have ongoing oral health.
Patient’s rights to dental treatment - the influence of the Covid-19 pandemic
Authors: Roi C. , Roi A. , Nicoară A. , Riviș M.
Published: November 2024

Aim and objectives: The present study aims is to observe and analyse the impact that the COVID-19 pandemic has on patients' right to have access to dental medical services. Both the national quarantine by decreeing the state of national emergency in Romania and the state of alert instituted due to the pandemic had an important impact on patients' appointments for dental procedures. Material and methods: We analyse the statistical data starting from the two groups of patients and follow the main differences that appear due to the COVID-19 pandemic. Group 1-non-pandemic included patients who presented themselves in the office between March 14, 2019 and March 14, 2020 and group 2-pandemic included patients who presented themselves in the office between March 15, 2020 and March 15, 2021. Conclusions: Following this study, we can say that the COVID-19 pandemic has a major impact on patients' right to dental treatment, affecting both access to services medical as well as unjustifiably delaying the treatment of dental pathology.
Three filters intravital fluorescence microscopy evaluation of tissue loss progression induced by ligatures in experimental peri-implantitis in a dog model
Authors: Rusu D. , Stratul S.I. , Boariu M.I. , Luchian I. , Boldeanu C. , Calniceanu H. , Vela O. , Kardaras G. , Chinnici S. , Veja I. , Igna V. , Roman A. , Soanca A.
Published: November 2024

Objectives: Tissue breakdown was obtained by placing ligatures around dental implants on the same edentulous dog hemimandible. Evaluation of hard tissue loss progression was performed using intravital fluorochrome labeling, as an alternative to standard light microscopy, on thin sections of non-demineralized hybrid bone-implant specimens. Material and Methods: Intravital fluorochrome labeling was administered by intraperitoneal injection of oxytetracycline and alizarin red S. Sections were cut, stained and evaluated by light microscopy and under the epifluorescent microscope. Bone loss architecture was analyzed under three filters: UV, green and red. Results: Epifluorescence microscopy demonstrated continuous bone activity in the surrounding area of the implants during the healing period. LM confirmed the intense cellular activity in the hard tissues around the implants. Conclusion: Within the limits of the present study, epifluorescence can be seen as a complementary approach to the LM “golden standard”, providing both reliable and sufficient information with regard to bone resorption/apposition kinetics.
Correlations between the age of dental implants and color changes of the peri-implant mucosa
Authors: Țandără A. , Funieru C. , Oancea R. , Preoteasa C. , Slușanschi O.
Published: November 2024

Aim and objectives: The aim of the present study is to detect the presence of changes in the color of the peri-implant mucous membranes in a group of patients with implants supported dentures and to correlate these changes with the age of the dentures. Our study group consisted of 62 patients with one or more dental implants placed between 6 months and 5 years prior to the study. Data were collected by dental examinations and were photographically documented. Later, the data were introduced and analyzed in SPSS software, version 14.0. The correlations revealed that all patients with peri-implant mucosal discoloration had prosthesis placed in the previous 2 years. If these color changes are not a sign of peri-implant inflammation, we recommend evaluating them regularly to follow their evolution.
Apical resection in oral surgery: current data
Authors: Vasca E. , Nicoară A. , Riviș M. , Todor S.A. , Olariu I. , Matei R.I.
Published: November 2024

Apical surgery is considered a standard oral surgical procedure. It is often a last resort to maintain a tooth with a periapical lesion that cannot be managed with conventional endodontic (re)treatment. The main goal of apical surgery is to prevent bacterial leakage from the endodontic system into the periradicular tissues by placing a filling at the root end after its resection. The microscope and the endoscope in dentistry have enabled a significant evolution in apical surgery techniques. Indeed, the microscopic enlargement with the addition of light optimizes the visibility of the operating field and improve the results.
The attitude regarding dental pain among a group of Romanian adults
Authors: Sfeatcu R. , Didilescu A. , Dimciu A. , Oancea R. , Cărămidă M.
Published: November 2024

Dental pain is a common symptom for oral conditions and most frequently caused by the dental disease. The aim of the present study was the assessment of Romanian adult patients’ attitude toward dental pain. Material and method: the cross-sectional study was conducted in 2022-2023 on a sample of 200 adults using an on-line self-administered questionnaire. Results showed that 32.2% of the participants experienced dental pain at least 1 time/year, and the most frequent approaches were scheduling a dental visit (67.5%) and self-medication (42.5%). Only 29% visited the dental office as soon as the pain was felt and the main reason for postponing was the costs of the dental treatments. Analgesics were the preferred medicine for pain management (74%), most frequently ibuprofen (59.5%). Conclusion: Participants in the present showed a suboptimal attitude toward dental pain, tending to postpone the dental visits to address the condition and self-medication with analgesics was largely observed.
The healing process of the postextractional alveolar bone of the wisdom tooth
Authors: Roi A. , Riviș M. , Mihai L.L. , Voinescu G. , Roi C.
Published: November 2024

Aim and objectives: Wound healing after tooth extraction is a dynamic process and represents an ongoing challenge in the surgical field. Specialists have focused their attention on healing management, addressing various treatment techniques. In this context, the aim of this study is to research and analyse the factors that influence the healing of the post-extraction alveolar bone of the wisdom tooth. Material and methods: This observational study analyses the healing process and the complications that appear after the tooth extraction. Conclusions: The study demonstrated that most patients did not experience post-extractional healing complications. Postoperative management of patients who experienced complications resulted in complete recovery.
The implications of phytotherapy in the management of periodontal disease
Authors: Muntean I. , Roi C.I. , Rusu L.C. , Rivis M. , Mihai L.L. , Puscas A. , Roi A. , Leretter M.T.
Published: November 2024

Periodontal disease has a high prevalence worldwide and is estimated to affect up to 90% of the world population. Currently, the attention was directed towards the effects of the herbal extraction in prevention and management of the periodontal disease. Taking into consideration their antimicrobial activity and immunomodulatory action, plant extracts can influence the treatment outcome. This review aims to provide an overview of the implications of different herbal extracts as adjuvant therapy and the outcome of the cases compared to standard controls. By integrating the herbal plant extracts and essential oils into different oral hygiene products as well, the first signs of inflammation can be controlled. The results highlighted an important antimicrobial action upon the most common pathogens of the periodontal disease, offering important advantages in the management of this disease.
Conservative treatment of the dental pulp in the young permanent dentition
Authors: Hosszu T. , Lile I.E. , Berari A. , Marian D. , Freiman P.C. , Stana O.L. , Stana A. , Flueras R. , Popa M. , Dinu S. , Ilyes I.
Published: November 2024

Aim and objectives: The purpose of this clinical trial was to evaluate the effectiveness of calcium hydroxide [Ca(OH)2] and mineral trioxide aggregate (MTA) in treating deep carious lesions using the direct total caries removal approach. The objective of treatment planning for young permanent teeth is to ensure the well-being of the pulp, while also facilitating ongoing root growth and the natural formation of dentin. Material and methods: The study was carried out on 81 teeth with advanced caries treated by indirect pulp capping using calcium hydroxide and MTA. Results: Following therapy, the recall rates were 92% at six and twelve months. Endodontic emergency treatment was provided for four teeth that were capped with Ca(OH)2 (2 at 6 months and 2 at 12 months posttreatment), and two capped with MTA (2 at 12 months posttreatment), due to signs of irreversible pulpitis that were confirmed clinically and/or radiographically. Between the two pulp-capping agents at six and twelve, there were not significant differences in pulp vitality. Conclusions: When it comes to indirect pulp-capping success can be achieved with both materials: calcium hydroxide and MTA.
Preclinical evidence on the potential of silibinin in liver cancer therapy
Authors: Geamantan A. , Marcovici I. , Macasoi I. , Dehelean C.
Published: November 2024

Liver cancer is a public health problem worldwide, hepatocellular carcinoma (HCC) constituting 90% of cases. Although research is in continuous development, the prognosis of this type of cancer remains unfavorable, as selective treatments with low toxicity are necessary. Silibinin is a flavonoid recognized for its hepatoprotective effect, antioxidant and anti-inflammatory properties, and also for its proven effectiveness in cancer treatment when administered indiviadually or in association with conventional therapies.
Post covid Follow up on Diabetic Patient
Authors: Romanescu D. D. , Beiusanu C. , Maghiar A. M. , Bostan A. C. , Micula Cociuban C. L. , Macovei I. C. , Bimbo-Szuhai E.
Published: November 2024

Aim and objectives: This study aimed to explore insulin necessity in hospitalized patients with non-insulin-dependent diabetes mellitus (DM) for the first six months after COVID-19 infection. A pro-inflammatory and pro-coagulative status probably contribute to the risk of worse outcomes in diabetes. Material and Methods: A number of 78 non-insulin necessitate diabetic patients with COVID-19 infection which needed oxygen therapy were included in the research. There were collected parameters routinely assessed to detect the possible predictors of diabetic patient evolution in SARS-CoV-2 infection. Results: The evolution of insulin necessity for 78 patients with non-insulin-dependent DM at admission was towards transformation into insulin-dependent DM at 6 months after discharge in 30 cases (38.5%), while the rest of the patients remained on oral antidiabetic drugs (48 patients, 61.5%). Conclusions: At hospitalized diabetic patient with covid-19 infection under corticotherapy, statistically significant differences were noted in HbA1c and aPTT level at 3 and 6 months after discharge.
Diagnostic Marker of Interleukin 6 in Acute Pancreatitis
Authors: Domocos D. , Popovici R. , Rosan C. A. , Bei M. F. , Pogan M.
Published: November 2024

Cytokines exert their action by binding to specific receptors on the cell surface. The experimental model of acute pancreatitis has conclusively shown that TNF-α (tumor necrosis factor), IL-1 (interleukin) and IL-6 are also produced outside the pancreatic parenchyma. This phenomenon occurs one hour after the induction of acute pancreatitis, being accompanied by appreciable histological changes in the pancreas. IL-1 and TNF-α have as primary inducers the production of IL-6 and IL-8 and both occur systematically in acute pancreatitis. IL-6 is the major cytokine mediator of the acute phase response and is produced by monocytes, macrophages and endothelial cells. IL-6 is a measure of systemically activated pro-inflammatory cytokines. The serum level of IL-6 also reflects the severity of acute pancreatitis, its growth precedes that of C-reactive protein by 24-36 hours. IL-8 is the secondary mediator of TNF-α-induced neutrophil activation. It is a chemotactic factor that attracts neutrophils and plays a significant role in the development of MODS (multiple organ dysfunction), especially in acute pulmonary injury, associated with sepsis.
Parotid Gland Lithiasis in Stensen’s Duct. Case Report
Authors: Bumbu B. A. , Precup A. I. , Pasca C. , Berari A. , Vasca E. , Stana O. L.
Published: November 2024

Salivary disease may result as a side effect from long term medications in chronic patients, dehydration, autoimmune diseases, ductal stenosis, smoking, trauma to salivary glands or due to systemic illness. Patients with sialoliths present a dysfunction related to salivary secretion. Salivary gland stones or calculi are the most common disease of the salivary glands most common in men aged between 30 to 60 years old. More than 85% of salivary sialoliths occur in the submandibular gland, 5–15% occur in the parotid gland and around 2% are in the sublingual and minor salivary glands. The article will present the case of an 84-year-old male patient with a parotid gland sialolithiasis.
Access to health assessment services for confirmed COVID-19 patients in Bihor County, Romania
Authors: Rahotă D.M. , Cămărășan A. , Rahotă D. , Moga D.T. , Moga I. , Rahotă R.G. , Mureșan M. , Pop O.
Published: November 2024

Aim and objective: This study presents the usefulness of a geographical information system to identify issues related to geographical access of COVID-19 confirmed individuals to established assessment services, in Bihor County, Romania. Material and method: Using the QGIS application, a geographic information system (GIS) was created with the following layers: the centroid of county localities, the assessment centres of confirmed cases, the corresponding 30-minute and 60-minute intervals for vehicle travel time from the localities to the assessment centre. Results: Determination of travel time (personal car or ambulance) from localities to an assessment centre was performed using isochrones for 30 minutes and 60 minutes. The ORS Tools plugin was used to plot the isochrones as a map. Conclusions: These analyses performed may provide key information for the development of health policies that promote safety and well-being in relation to the risks associated with COVID-19. Data are provided on areas with reduced access to healthcare resources.
Genetic testing approach in cardiomyopathies comparing NGS panels, WES and WGS
Authors: Voinescu O. R. , Ionac A. , Sosdean R. , Ionac I. , Morariu V. I. , Puiu M. , Chirita-Emandi A.
Published: November 2024

Background: Genetic testing in cardiomyopathies has a great impact on diagnosis and further management. Considering novel technologies developed for DNA sequencing, it is important to understand the indication and limits of genetic testing available, while taking cost-efficiency into account. Aim: The focus of this review is to summarize the current genetic testing approach in cardiomyopathies in order to determine the best patient pathway in reaching a genetic diagnosis. Methods: For this narrative review, we performed a search of several electronic databases, selected and evaluated relevant manuscripts. Results: Each method of genetic testing in cardiomyopathies was assessed in terms of the diagnosis yield, benefits, limitations and turnaround time. Conclusion: Whether the use of whole exome or genome sequencing can improve the performance of genetic diagnosis in cardiomyopathies over standard custom panels is challenging and needs to be determined in future researches.
A bibliometric analysis of digitalization challenges in healthcare systems of the European Union
Authors: Luca M. , Nikolajevic-Stoican N. , Buzatu B. , Galuscan A. , Panaite M. A. , Popa M. , Buzatu R.
Published: November 2024

This study aims to analyze the challenges in health systems at the level of the European Union in terms of digitization, with the help of bibliometric analysis. The proposed empirical analysis aims to select the most relevant scientific articles from the Web of Science Core Collection, a highly trusted scientific literature database, due to its comprehensive coverage of high-impact journals across the world, including open access journals, conference proceedings and books. Bibliometric analysis is a methodical approach to quantifying the state of knowledge in the field of digitization of health systems in the EU, involving several steps, each designed to provide insights into publication patterns, citation patterns and the overall landscape of academic research. Two concepts were considered, respectively “e-health” and”digital,” following that the type of articles included was only”Article”, and as the last condition for the search was the analysis period that was between the years 2010-2022. The visual results of the investigation undertaken indicate a significant increase in interest in the topic investigated in our study, observable not only among the member countries of the European Union, but also internationally. This trend reflects the relevance and novelty of the topic in the global scientific community.
Prospective study on Glutathione expression and immune response in the oral cavity of diabetic patients
Authors: Slăvescu D. A. , Frățilă O. , Moca A. E. , Vaida L. L. , Iurcov R. , Lixandru N. , Rusu M. , Vasca E. M.
Published: November 2024

Aim and objectives: This study aimed to investigate the association between antioxidant protection factors (glutathione and MTH1/MUTH) and immune response (CD3-lymphocyte T and CD20-lymphocyte B) in the oral cavity mucosa of diabetic patients. Material and methods: Glutathione levels and immune cell expressions (CD3 and CD20) were measured in the oral mucosa of diabetic patients and compared with a control group using immunohistochemical analysis. Results: Diabetic patients had significantly lower glutathione levels and altered immune responses, with higher oxidative stress in B lymphocytes (CD20) and T lymphocytes (CD3). The T/B lymphocyte ratio was significantly higher in diabetic patients, indicating immune imbalance. Conclusions: Diabetic patients showed reduced glutathione levels and a higher T/B lymphocyte ratio in the oral cavity, suggesting that oxidative stress negatively impacts immune function. This highlights the need for antioxidant therapies in managing oral health in diabetic patients.
Legal considerations on criminal liability in the medical field
Authors: Tănase A. D. , Popa A. , Bojoga D. E. , Negrutiu M. L. , Pop D. M. , Novac A. C. , Soter A. D. , Miok K. , Petrescu E. L.
Published: November 2024

Medical criminal liability is a current, leading to a series of consequences regarding the future professional life of doctors. In the context where the health and safety of patients are major priorities, understanding legal medical responsibility is essential for ensuring the quality of medical services and preventing the commission of acts that constitute offenses. Materials and Methods: To conduct this observational-prospective study, a questionnaire consisting of 10 closed choice or selection questions was compiled, aiming to analyse the level of information among dentists regarding the Romanian legislation that regulates the legal framework for engaging the medical staff's liability once offenses related to the practice of the profession are established. Results and Discussions: After the completion period ended, the questionnaires were centralized and statistically analysed. Dental practitioners from urban areas are better informed about the medical legislation and are aware how to protect themselves against and their professional activity. Conclusions: The main conclusion of this study focuses on the importance of increasing the level of information among dentists regarding the content of the existing criminal legislation currently in force in our country, and one of the professional bodies that could contribute to this is the College of Dental Physicians of Romania through its active involvement.
Impact of dietary habits on health outcomes in children and adolescents with poor oral hygiene
Authors: Motoc G. V. , Moca A. E. , Juncar M. , Marian P. , Trusculescu L. M. , Pitic D. E. , Irimie C. , Olariu I.
Published: November 2024

Aim and Objectives. This study aimed to investigate the relationship between nutrition and the health status of children with poor oral hygiene. Specifically, it sought to identify factors influencing their health and to explore strategies for improving their nutrition and overall well-being. Material and Methods. Conducted at the Pediatric Department of the Emergency County Clinical Hospital in Oradea, the study reviewed medical records of patients aged 0 to 18 years hospitalized from May 13, 2023, to June 13, 2023. Inclusion criteria encompassed patients with poor oral hygiene, excluding those with chronic general diseases or syndromes. Demographic and dietary data were analyzed alongside laboratory parameters and systemic pathologies. Results. Among the 100 participants, the majority were male, with normal weight status, and followed artificial or mixed diets. Pathological alterations were predominant in the respiratory system, while no significant association was found between dietary patterns and pathological changes in other systems. However, significant correlations were observed between specific dietary habits and paraclinical parameters, such as Total-IgE and CPE levels. Conclusions. This study emphasizes the critical role of nutrition in children's health, particularly in the context of poor oral hygiene. Findings suggest that a natural or mixed diet may mitigate risks associated with allergies and immune disorders compared to an artificial diet. Advocating for balanced nutrition strategies could offer substantial benefits in mitigating chronic ailments and enhancing long-term health outcomes in children. Further research is warranted to validate and expand upon these findings.
Evaluating aesthetic benefits of composite veneers: investigating dental students and lay people's self-perception
Authors: Kui A. , Biasi G. , Negucioiu M. , Aron R. , Buduru R. , Buzatu R. , Țig I. A. , Buduru S.
Published: November 2024

Aims and objectives: This study aims to explore how demographic variables such as gender, age, and country influence perceptions related to dental health and aesthetics. Materials and methods: We conducted an online survey, gathering responses from participants across various countries. The survey included questions ranging from satisfaction with dental aesthetics to the perceived benefits of dental treatments such as veneers. Results: The results revealed significant differences in dental health perceptions based on gender, with males generally more satisfied with their gum health compared to females. However, age did not significantly influence dental health perceptions, suggesting a universal concern across age groups. The country of residence significantly affected perceptions of the confidence-boosting effects of dental veneers, highlighting cultural differences in dental aesthetics. Conclusions: The findings emphasize the need for dental health professionals to consider demographic factors when planning treatment and education programs. Gender differences suggest that targeted educational campaigns might be necessary to address specific misconceptions and expectations.
Digital workflow for ten upper veneers: a case report
Authors: Tăut M. , Dumbrovca B. , Kui A. , Negucioiu M. , Buzatu R. , Țig I. A. , Buduru S.
Published: November 2024

Aim and objectives: The purpose of this article is to present the case of ten upper veneers using a full digital protocol in the interest of evaluating the results both estethically and functionally, duration of the whole process, overall cost, the efficiency of the workflow and patient’s satisfaction. Material and Methods: The digital workflow consisted of a previsualization of the final result by using the Smile Cloud application, therefore creating a digital wax-up and printing a model for the mock-up. The ten upper preparations from first molar to first molar were performed. In the end, after the intraoral scanning of the preparations, the restorations were milled from ceramic ingots in CAD-CAM 5-axis milling unit and tried-in in order to verify the integration and adaptation, finally ten upper monolithic veneers being cemented. Results: The digital workflow allows to have a predictible final result – especially esthetically, offering a natural final touch thanks to micro and macro textures, alongside with color choice and shade integration, improving the whole facial aspect. Conclusions: In terms of time and predictability, the digital workflow offers a better time-management and faster results, alongside with an improved esthetic outcome. The duration of the entire clinical process was shorter compared to the average time for conventional protocol, increasing patient’s satisfaction for the whole treatment. Overall cost can surpass the usual one of traditional workflow, as the CAD-CAM system used, the software updates and the special-created materials for digital protocol require significant financial investment.
Interdisciplinary approaches to preventing oral complications in diabetic patients: a systematic literature review
Authors: Galuscan A. , Balean O. , Dumitrescu R. , Alexa V. , Sava-Rosianu R. , Floare L. , Jumanca D. E.
Published: November 2024

In the last three decades the number of people with diabetes has doubled. The global prevalence of diabetes mellitus (DM) is rapidly rising as a result of population aging, urbanization and associated lifestyle changes. Among the complications in the oral sphere of diabetes were reported: periodontal disease (PD) (the most important oral disease correlated with diabetes), xerostomia, oral candidiasis, glossodynia, slow healing of the tissues of the oral cavity, as well as other conditions for which it would be necessary to implement early prophylactic and therapeutic measures. This systematic literature review was conducted to answer the following questions: The primary question: What are the ways to prevent periodontal disease and oral mucosal diseases in DM patients? And the secondary questions were: How were these methods evaluated in the studies included in the research? What is the level of knowledge of both patients and diabetologists regarding the prevention of these oral complications in diabetic patients? 436 bibliographic references were identified and were centralized in a file. The studies were evaluated according to their title and abstract, following the extent to which they correspond to the inclusion criteria. After analyzing the titles, 351 articles were excluded and the remaining 86 had their abstracts evaluated. 25 articles were selected and read in full, two of which were excluded because they proved not to be relevant to the chosen topic. Thus, finally, 23 studies were included in the systematic review. The most important conclusion was that: an interdisciplinary collaboration is necessary between health specialists, dentists and diabetologists alike, with the aim of developing programs to educate diabetic patients about the oral complications of DM and their prevention.
The aesthetic impact of black stains in paediatric patients - a study of chemical and microbiological composition
Authors: Buzatu R. , Paulinskyi D. , Ivan D. , Popa M. , Nikolajevic-Stoican N. , Luca M.
Published: November 2024

The present study aims to present the clinical implications of black stains but also their microbiological and chemical components. The study involved three paediatric patients divided into two groups on which samples were taken and through specific tests the presence of extrinsic chromogenic bacteria as well as metals and sulfuric components was demonstrated. The microbiological and chemical evaluation provides additional information that can be used by clinicians to improve the treatment protocol by knowing the bacteria involved and their specifics.
Review: The tumor microenvironment of melanoma
Authors: Mihulecea (Jitian) C.-R. , Ceaușu A. R. , Gaje N. P. , Rotaru M. , Raica M.
Published: November 2024

Aim and objectives: Melanoma is one of the most complex skin cancers based on its numerous somatic mutations and chromosomal instability. Besides the traditional causative factors, such as ultraviolet radiation, or genetic factors, recent studies showed that melanoma highly depends on its adjacent microenvironment. A malignant tumor, like melanoma, is composed of oncogenic cells, regular cells (melanocytes, macrophages, mast cells, keratinocytes, and others), the supporting stroma, which includes fibroblasts, endothelial cells, immune cells, soluble molecules, and the extracellular matrix (ECM). This article aims to present the tumor microenvironment's main functions in the development or progression of melanoma. Material and methods: we have studied some of the most recent 30 articles based on the role of the microenvironment in melanoma. Results: After analyzing the most recent articles regarding melanoma’s tumor microenvironment (TME) and its impact, we have found that the cells that comprise the TME can affect melanoma’s onset or progression. TME’s cells actively interact with each other and have many functions, from tumor-suppressing roles to the initiation or progression of melanoma. Conclusions: Understanding the complex interplay between tumor cells, and systemic mediators of disease progression is critical for the rational development of effective melanoma treatments. Each cell involved in the TME can play an important role either in the onset or advancement of melanoma with the help of certain mutagenic factors.
The role of communication in the success of therapeutic interventions in dental practice
Authors: Tănase A. D. , Negrutiu M. L. , Petrescu E. L. , Pop D.M. , Novac A. C. , Bojoga D. E. , Soter A. D. , Miok K. , Cosoroabă M. R.
Published: November 2024

The professional relationship between dentists and patients encompasses the provision of medical care and needs to be completed by an ethical and accurate communication. This highlights the significant emphasis placed on the interaction between medical staff and patients in medical practice. The success of dental treatments also hinges on the dentist's ability to establish a connection through communication with patients, paying attention to their needs, and demonstrating empathy and care towards them. Materials and Methods: For this observational-prospective study it was developed a questionnaire consisting of 10 closed-ended questions. The aim is to assess patients' opinions regarding the role and impact of communication in their relationship with dentists and on the success of medical treatment. Results and Discussions: The results indicate that the majority of patients evaluate their collaboration with dentists from a medical perspective but also through the way of communication and interaction quality. There is a strong emphasis on how healthcare providers are aware by their patient’s needs, demonstrating empathy and skills in their professional collaborations. Conclusions: The primary conclusion of this study centers on the development of communication skills among dentists to achieve successful therapeutic outcomes, given the increasing needs of patients in the present context.
Manual vs. power toothbrush efficiency on plaque removal in patients with fixed orthodontic appliances
Authors: Bica I. , Oancea R. , Funieru C.
Published: November 2024

Aim and objectives: The main goal of this study is to compare the efficiency of manual and power toothbrushes in dental plaque removal on patients with orthodontic appliances. Material and methods: 30 patients aged from 12 to 29 years were selected for this study, 17 of them being girls/women. Half of them received education for manual toothbrushing and the other half for using power toothbrush. An adapted version of Ciancio plaque score was used for the plaque measurements. Results: Patients who used power-toothbrushes seem to have a lower plaque score but the results were not statistically confirmed (p > 0.05). Conclusion: Using a power-toothbrush may be an advantage during the orthodontic treatment.
Clinical assessement of ceramic inlays compared to resin composite inlays- literature review
Authors: Petrescu E. L. , Negruţiu M. L. , Sinescu C. , Romînu M. , Pop D. M. , Abdi H. B. , Tănase A. D. , Leretter M. T. , Antoniac I. , Manole M.
Published: November 2024

The development and enhanced performance of restorative dental materials—both direct and indirect restorative materials, along with adhesives—are paving the way for minimally invasive dental treatments. High-performance composite resins and ceramic materials, when appropriately matched to the clinical case, ensure excellent restorative outcomes. These outcomes include superior aesthetics, precise marginal fit, conservative or minimal tooth preparation, strong adhesion, and long-term success. Materials and Methods This systematic review analysed various published studies with similar objectives and a minimum follow-up period of 3 years. The outcomes assessed included quantifiable factors such as tooth and restoration fractures, chipping of both teeth and inlay restorations, the frequency of endodontic issues, secondary caries, and debonding. Results and Discussions The selection of a material for inlays and onlays need to absorb significant occlusal forces. Consideration regarding the durability and effectiveness of the selected materials used through direct or indirect technique and clinical case are essential for a long-term success. The survival rate of adhesive restorations is heavily influenced by factors like dental cement and adhesive system, marginal fit, bruxism and interdental contact areas. Conclusions: Ceramic inlays and onlays have shown higher survival rates over a 5-10 year period of time compared to alternative materials such as composite resin. Fractures is the most frequent type of failure for composite resin restorations. This evidence indicates that ceramic inlays are a highly successful treatment option with a very favourable prognosis.
CAD/CAM applications for implant-supported prosthesis
Authors: Pop D. M. , Novac A. C. , Vieru M. O. , Petrescu E. L. , Sinescu C. , Negruțiu M. L. , Buzatu R. , Leretter M.
Published: November 2024

Introduction: The integration of CAD/CAM technology with high-strength ceramics enables the creation of all-ceramic restorations, even in posterior regions. These restorations are typically composed entirely of ceramic material. Alternatively, a high-strength ceramic substructure can be utilized, necessitating ceramic veneering and glazing. CAD/CAM milling techniques, along with the advent of new zirconia ceramics, facilitate the production of full-zirconia restorations featuring occlusal design, without the need for veneering. Aim of the Study: The aim of the study is to assess the abrasion of zirconia restorations in comparison to ceramic ones, and also to evaluate the abrasion of the opposing teeth to these restorations. Material and Methods: The specimens, totaling 16 in number with a diameter of 5mm and a thickness of 2mm, were crafted from various ceramic materials. The zirconia specimen underwent glazing immediately after polishing. Ceramic veneers were chosen to be applied onto the zirconia substructures. Human enamel and Vita Omega 900 ceramic, typically utilized in metal-ceramic restorations, served as reference materials. The ceramic veneers were glazed using the appropriate glazing material. The specimens were then smoothed using abrasive paper while being cooled with cold water. Surface roughness was assessed before conducting the abrasion tests using a profilometer. Standard abrasion simulation was achieved using steatite spheres as antagonists. Results and Discussions: Zirconia demonstrates greater resistance to abrasion compared to ceramic materials. Interestingly, in the subsequent analysis, the hypothesis suggesting that the reduced abrasion observed for zirconia would coincide with increased abrasion of antagonists was disproved. Although enamel antagonists were not quantitatively assessed, comparison of SEM micrographs revealed similar wear patterns for both steatite and enamel. The materials tested represent typical zirconia ceramics commonly employed in the fabrication of all-ceramic substructures. Conclusions: The abrasion tests conducted with steatite or enamel antagonists did not reveal any noticeable abrasion on the surface of zirconium oxide. Ceramic exhibited comparable or even lower rates of abrasion compared to enamel. The abrasion experienced by antagonists against zirconia was found to be similar or even lower when compared to the results observed with ceramic.
Continued root-growth and apexification procedure of immature permanent incisors using calcium hydroxide
Authors: Ilyeș I. , Marian D. , Olariu I. , Ghircău Radu R. , Olariu T. , Cosoroabă R. M. , Talpoș Ș.
Published: November 2024

Teeth with incomplete apical development or with a wide apex (unformed apex) have the etiology of complicated dental caries or a trauma with pulp exposure and periapex damage, before the root is fully matured. Two male patients aged 9 and 7 years old with history of carious pathology and dental trauma were selected for the apexification procedure. Apexification produced consistent results in the treatment of immature teeth with pulp necrosis and apical periodontitis.
Exploring Deprivation Experiences among Senior Citizens: A Strategic Gender Needs Analysis Framework in Davao City
Authors:   University of Southeastern Philippines, Salazar Gene Anthony
Published: November 2024

This study is aimed at developing a strategic gender needs framework for the senior citizens in Davao City. The study used a convergence-parallel mixed methods design and a snowball sampling technique. As part of the quantitative study, a survey questionnaire consisting of 20 items was used to collect data from the 20 senior citizen participants. On the other hand, a qualitative study was also facilitated through the key informant interviews of two elders. The location of the data gathering is in Davao City. The mean and t-test were the statistical tools used in the study. Also, data triangulation was utilized to check the convergence (divergence) of the results.

The study’s findings showed that senior citizens’ levels of deprivation were high in terms of help-seeking behavior. In the same manner, the participation level in terms of family and community decision-making was very high. Meanwhile, it was found that there is a significant difference in the level of deprivation experienced in terms of help-seeking behavior and participation in decision making among senior citizens when grouped according to age. This concurs with the fact that, as they age, they are likely to experience deprivations. On the other hand, the study concurred that there is no significant difference in the level of deprivation experienced in terms of help-seeking behavior and participation in decision-making among senior citizens when grouped according to sex, primary source of income, average monthly income, and medical history. Given the qualitative data, this study confirmed that the salient and dominant themes triggered in the thematic analysis are: the prolonged turn-around time in the scheduled social pension pay-outs; the insufficient amount of social pension; the lack of livelihood training or programs obtained; and the age discrimination to access work. Furthermore, significant statements about the deprivation experiences of senior citizens were analyzed, which resulted in a common category called “poverty.”

Lastly, Senior Citizens on Relevant Enactions (SCORE) is the proposed strategic gender needs framework for the senior citizens in Davao City that aims to provide an avenue to enhance their living conditions through suitable and relevant strategies and programs.