bluuebunny/crossref_metadata_2025 huggingface dataset:
Fractionation of fish waste oil through low-temperature crystallization in acetone followed by urea complexation
Authors: Rastegari Hajar , Espootin Simin , Ghaziaskar Hassan S. , Yatim Norhafiza Ilyana , Ali Nora’aini
Published: August 2022

Fatty acids fractionation has enabled the introduction of many fatty acids into new food/feed applications. Yet, a simple, efficient, and low-cost process to separate biomass oily feedstocks into valuable fatty acids fractions remains a challenge. Herein, a new, efficient, and simple fractionation method is developed to obtain enriched polyunsaturated fatty acids fraction from fish waste oil using acetone for crystallization at low-temperature followed by urea complexation. This method obtained two fractions, one enriched in polyunsaturated fatty acids, and the other enriched in saturated fatty acids. The fraction enriched in polyunsaturated fatty acids contained oleic, eicosapentaenoic, and docosahexaenoic acids with mass percentages of 58, 20, and 22%, respectively. While the fraction enriched in saturated fatty acids contained 78, 12, 5, and 5 wt.% palmitic, myristic, oleic, and stearic acids. The solvent was recovered from the liquid phase with an efficiency of 80% and reutilization of it obtained almost identical results.
Sensitive and Specific Analysis of Two Banned Phenyl Xanthene Dyes in Bottled Chili Sauce by High Performance Liquid Chromatography- Fluorescence Detection
Authors: Ali Hazim M.
Published: August 2022

The risk of human exposure to phenylxanthene dyes is widely documented. Preliminary analysis of bottled chili sauce samples revealed the presence of two banned phenyl xanthene dyes (rhodamine B and eosin Y). Therefore, a simple, specific, and sensitive approach was implemented for the simultaneous estimation of rhodamine B (RhB) and eosin Y (EsY) in bottled chili sauce. The first high performance liquid chromatography-fluorescence detector (HPLC-FLD) was used for the simultaneous estimation of RhB and EsY, based on their native fluorescence. In addition, to overcome the difference in the excitation and emission wavelengths between the two dyes and maintain their sensitivity, a zero-order emission mode was selected in the fluorescence detector (FLD) unit. The excitation wavelength was adapted at 530 nm in mobile phase composed of 0.1% formic acid in ultrapure water (A) and methanol (B) at ratio of 30:70 v/v). Furthermore, using the Sep-Pak® C18 cartridge for solid-phase extraction method, interference from the chili sauce matrix was eliminated. Under the optimum condition, a linear calibration graphs in the range of 0.5- 300 and 0.5- 300 of RhB and EsY with r = 0.9994 and 0.9991, respectively were acquired. The limits of detection for RhB and EsY were 0.344 ng/mL (0.355 ng/g) and 0.215 ng/mL (0.222 ng/g), respectively. The recovery percentage and relative standard deviation of two analytes were obtained in the range of 98.38-101.86% and 0.83-1.66 % respectively. According to the results, the presented method offers specificity, convenience and sufficient sensitivity for the simultaneous estimation of RhB and EsY in wide variety of food matrices.
Antimicrobial resistance genes of fermented red pepper (FRP) related food in a large-scale environment: distribution pattern and risk assessment
Authors: Li Zhihua , Zhao Chi , Dong Ling , Zhang Fengju , Chen Yaxi , Zhou PingPing
Published: August 2022

Background
Antibiotic resistance genes (ARGs) are rapidly increasing numbers of difficult-to-treat infections and have been taken as a severe global health threat, which is estimated that the number of approximately 700,000 annual deaths and will exceed 10 million deaths per year by 2050 due to ARGs. Recently, ARGs involved in fermented foods have been taken more attention due to the spread of ARGs throughout the food chain. As well known, fermented red pepper (FRP) foods have been consumed widely as their unique flavor and health beneficial effects. However, knowledge gaps are still in the risk assessment of FRPs and their dissemination patterns on a large scale, which limited the development of effective methods to control and monitor the ARGs in fermented food. Here, a combination of read- and assembly-based whole genome sequencing methods as well as amplicon sequences analysis was used to investigate and reveal the ARGs dissemination patterns and risk assessment in FRPs related foods on a large-scale metagenomic data.
Results
65.38% of FRP samples contained high-risk ARGs need to be concerned. Multidrug resistant (MDR) was the highest abundant type. On average, tetL and tetracycline resistance protein account for 81.8%, followed by multidrug (7.5%), beta-lactam (5.5%), colistin (1.5%), aminoglycoside (1.1%), and macrolide-lincosamide-streptogramin (1.1%) in the highest risk level, and the corresponding host range crossed from genus to bacteria indicating high mobility. Bacillus, Enterobacter, and Pantoea were the predominant host of carrying ARGs, which involved three major classes of resistance mechanism, that is, antibiotic efflux, antibiotic inactivation, and antibiotic target alteration. In addition, various ARGs and virulence factors with significant positive or negative relationships have been revealed.
Conclusion
Our findings demonstrated various ARGs were present in FRPs and high-risk ARGs such as tetL, tetracycline resistance protein, multidrug, beta-lactam, colistin, aminoglycoside, and macrolide-lincosamide-streptogramin has high mobility from genus to bacteria, which were significantly positively or negatively related to virulence factors. These results not only pave a way for understanding distribution patterns of ARGs in FRP foods on a large scale but also provide valuable knowledge to monitor and mitigate the ARGs.
Value of Central Review of RECIST v1.1 Outcomes in the AGITG INTEGRATE randomised phase 2 international trial for advanced oesophago-gastric cancer
Authors: Sjoquist Katrin M. , Martin Andrew , Pavlakis Nick , Goldstein David , Tsobanis Eric , Moses Daniel , Maher Richard , Hague Wendy , Gebski Val , Stockler Martin R. , Simes R. John
Published: August 2022

Purpose
Activity estimates should be accurately evaluated in phase 2 clinical trials to ensure appropriate decisions about proceeding to phase 3 trials. RECIST v1.1. progression-free survival (PFS) is a common endpoint in oncology; however, it can be influenced by assessment criteria and trial design. We assessed the value of central adjudication of investigator-assessed PFS times of participants in a double-blind, randomised phase 2 trial evaluating regorafenib versus placebo in advanced gastro-oesophageal cancer (AGITG INTEGRATE) to inform plans for central review in future trials.
Methods
We calculated the proportion of participants with a disagreement between the site investigator assessment and blinded independent central review and in whom central review resulted in a change, then evaluated the effect of central review on study conclusions by comparing hazard ratios (HRs) for PFS based on site review versus central review. Post-progression unblinding was assessed with similar methods. Simulation studies explored the effect of differential and non-differential measurement error on treatment effect estimation and study power.
Results
Disagreements between site assessments versus central review occurred in 8/147 (5.4%) participants, 5 resulting in amended date of progression (3.4%). PFS HRs (sites vs central review progression dates) were similar (0.39 vs 0.40). RECIST progression occurred in 82/86 (95%) of cases where post-progression unblinding was requested by the site investigator.
Conclusions
Blinded independent central review was feasible and supported the reliability of site assessments, trial results, and conclusions. Modelling showed that when treatment effects were large and outcome assessments blinded, central review was unlikely to affect conclusions.
A dansyl-based fluorescent probe for turn-off and turn-on detection of Hg 2+ in a full water system
Authors: Sha Chunming , Li Zhengkun , Lu Shengzhou , Hu Xiaolong , Xu Dongmei
Published: August 2022

A dasnyl-based fluorescent probe, 2-((5-dimethylamino)naphthalene-1- sulfonamido)acetic acid (DNSG), was synthesized from dansyl chloride and glycine. In HEPES buffer (20 mM, pH 6.7), DNSG could detect Hg2+ by fluorescence quenching. The maximal fluorescence intensity showed a good linear relationship with the Hg2+ concentration (0 ~ 80 µM). The detection limit was 0.33 µM. With the help of silk fibroin (0.076 g/L), DNSG could detect Hg2+ by fluorescence enhancement and blueshift. The linear concentration range for Hg2+ was 0 ~ 160 µM with a detection limit of 0.81 µM. DNSG could detect Hg2+ quickly and reversibly with excellent anti-interference ability and further could assay environmental water sample efficiently. The sensing mechanism was examined by Job’s plot, mass spectrum and 1H NMR analysis.
Effect of alternative protein blends on Oreochromis niloticus (Nile Tilapia) fingerlings’ growth performance, nutrient utilization and carcass characteristics
Authors: Ronke Edem Bunmi , Oluwayemisi Adeparusi Eunice
Published: August 2022

This study was conducted to evaluate blends of alternative protein sources (gliricidia and moringa leaves) in the diet of Nile tilapia (Oreochromis niloticus) fingerlings. Five experimental diets containing 30% crude protein were formulated as fishmeal/soybean (FMS, control), fishmeal/moringa(FMM), fishmeal/gliricidia (FMG), fishmeal/soybean/moringa (FSM) and fishmeal/soybean/gliricidia (FSG) and fed to O. niloticus fingerlings for 10 weeks. A total of 150 fingerlings were distributed into 15 tanks in triplicates with 10 fish per tank. The findings showed fish given diets FMS, FMM, and FMG had similar weight gains, while fish fed diet FSM experienced weight gains that were significantly different (P < 0.05) from other experimental fish. However, the experimental fish's specific growth rate (SGR) and f protein efficiency ratio (PER) value did not change significantly (P > 0.05). Fish fed diet FSG had a feed conversion ratio (FCR) of 1.12 ± 0.01, while fish fed diet FMG had an FCR of 1.23 ± 0.02. Experimental fish's carcass protein, ash and fat contents varied significantly. This study's findings showed that Nile tilapia utilized the experimental diets effectively and could be supplemented with fishmeal.
Design and simulation of a semiconductor detector-based Compton imaging system with efficiency analysis
Authors: niknami mostafa , Hosseini Seyed Abolfazl , Loushab Mahdy Ebrahimi
Published: August 2022

Compton cameras have become widespread in recent years because it uses electronic collimators. One or more scatterer detectors and an absorber detector make up the Compton camera, which is sensitive to the energy and location of scattered gamma rays. It predicts the distribution of gamma-ray sources by reflecting all valid events in the image space using conical surfaces. Compton cameras are designed for specific applications and image reconstruction using various methods. Based on studies of the efficiency of the Compton camera, the current work provides a novel detector design that includes scatterer and absorber detectors. The Compton imaging system is simulated using the GEANT4 toolkit. In addition, this research uses an analytical method to reconstruct the Compton camera image. The method used for analytical reconstruction in the Compton imaging system differs slightly from the simple restoration methods used in other imaging systems. In the analytical method, the equation related to the data reflected by the image must be solved to reconstruct the image directly. In this method, C + + code required development to reconstruct images using the Compton camera. According to the results, using the analytical method to identify the best circumstances and the parameters impacting efficiency, the value of FWHM achieved was 3.7 mm with an angular uncertainty of about 2.7 at an energy of 0.662 MeV. Furthermore, the value of FWHM was decreased by 0.7 mm, compared to another (experimental) design that employed the analytical image reconstruction approach.
Analysis of Reclaimed Asphalt Pavement Heating with Microwave Radiation
Authors: SOROCIAK WOJCIECH , GRZESIK BARTŁOMIEJ , SZOŁTYSIK JOANNA , BZÓWKA JOANNA , MIECZKOWSKI PAWEŁ , KLEMENS MAŁGORZATA
Published: August 2022

The research focuses on the analysis of potential use of microwave radiation as alternative Reclaimed Asphalt Pavement (RAP) heating method. Material characteristics and the microwave heating possibility for the production of Hot Mix Asphalt (HMA) were verified. The research focused on testing HMA with different content of RAP and RAP of different moisture containing unmodified bitumen and modified bitumen with styrene-butadiene-styrene (SBS) polymer. Tests for density, bulk density, air void content and the Indirect Tensile Strength were carried out. The test results confirmed the possibility of using microwaves to heat the HMA without adversely affecting its basic properties. The research also shows the possibility of heating the RAP in the process of HMA production, especially with the RAP of a moisture content above 3%. In addition, the tests of HMA did not reveal any negative impact of microwave heating in the case of using moist RAP for the production of HMA. The susceptibility of the SBS polymer to microwave radiation was indicated by comparing the behavior of the two HMA types under its influence. HMA containing modified bitumen appears to achieve higher temperatures than HMA with unmodified bitumen after the same time of microwave heating.
Do Chinese Industry Spur Innovation to Embrace the Challenges of the Current Technological Revolution: Data Envelopment Approach
Authors: Usman Magaji Abdullahi , Sun Prof. Xinbo
Published: August 2022

The capacity base of the manufacturing sector plays a pivotal role in the process of wealth creation and economic growth of any country. The industrial innovative performance of an economy depends on the rigorous application of new ideas, methods of production, and modern techniques. This study uses the Malmquist productivity index of Data Envelopment Analysis (DEA), and the generalized ordinal model to investigate the actual innovation growth of China’s industrial enterprises. It also analyses the possibilities of the low innovative industries under study transforming into high innovative industries. The findings highlight that, although China’s industrial enterprises above high designated are on average experiencing a negative growth rate in terms of technical progress, yet they have spurred innovation with an average growth of 7% in total factor productivity. It concludes that there is a general need for the authority concern to lay more emphasis on reducing technical inefficiency, thereby improving technological innovation level and subsequent increase in overall efficiency scale.
Development of automated delivery quality assurance analysis software for helical tomotherapy
Authors: Yoon Young Hun , Shin Han-Back , Han Min Cheol , Kim Hojin , Kim Dong Wook , Hong Chae-Seon , Kim Jihun , Kim Jin Sung
Published: August 2022

Background: To develop a fully-automated in-house gamma analysis software for the “Cheese” phantom-based delivery quality assurance (QA) of helical tomotherapy plans.Methods: The developed in-house software was designed to automate several procedures, which need to be manually performed using commercial software packages. The region of interest (ROI) for the analysis was automatically selected by cropping out film edges and thresholding dose values (>10% of the maximum dose). The film-measured dose was automatically aligned to the computed dose. An optimal film scaling factor was determined to maximize the percentage of pixels passing gamma (gamma pass rate) between the measured and computed doses (3%/3 mm criteria). This gamma analysis was repeated by introducing setup uncertainties in the anterior-posterior direction. For 73 tomotherapy plans, the gamma analysis results using the developed software were compared to those analyzed by medical physicists using a commercial software package.Results: The developed software successfully automated the gamma analysis for the tomotherapy delivery QA. The gamma pass rate calculated by the developed software was higher than that by the clinically used software by 3.0%, on average. While, for 1 of the 73 plans, the gamma pass rates by the manual gamma analysis were higher than 90% (pass/fail criteria), the gamma analysis using the developed software resulted in fail.Conclusions: The use of the automated and standardized gamma analysis software can improve both the clinical efficiency and veracity of the analysis results. Furthermore, the gamma analyses with various film scaling factors and setup uncertainties will provide clinically useful information for further investigations.
Pulmonary Tuberculosis Bacilli Detection from Sputum Smear Microscopy Images Using K-Nearest Neighbor Classifier
Authors: Abdeta Diriba , Diriba Chala , Jimma Worku
Published: August 2022

Tuberculosis is a very deadly disease worldwide, including in Ethiopia. TB is caused by Mycobacterium tuberculosis, which can cause pulmonary tuberculosis disease. Sputum smear microscopy is the most commonly used diagnostic tool in developing countries. The main purpose of this study is to develop a k-nearest neighbor classifier model for detecting PTB bacteria from sputum smear microscopic images. This study developed an algorithm based on the image processing technique to identify pulmonary tuberculosis bacilli in a digital image of a stained sputum smear. Thus, k-nearest neighbor classifiers were used to identify bacilli from sputum smear images in two classes: bacilli detect and non-bacilli detect. The total sample size of the image dataset of 180 from stained sputum images of PTB bacilli infected was obtained from Ethiopian Public Health Institute (EPHI). The model's accuracy, sensitivity, specificity, and F-measures then provided an average performance of 92.6%, which is the average performance of the prototype KNN model's sensitivity of 93%, specificity of 92%, and F-measure of 94.7%.
Short- and long-term outcomes of preservation of the superior rectal artery versus ligation of the inferior mesenteric artery in laparoscopic D3 lymph node dissection for descending colon cancer: a propensity score-matched analysis
Authors: Sato Aya , Imaizumi Ken , Kasajima Hiroyuki , Ichimura Kentaro , Sato Kentaro , Yamana Daisuke , Tsuruga Yosuke , Umehara Minoru , Kurushima Michihiro , Nakanishi Kazuaki
Published: August 2022

Purpose
This study aimed to compare the short- and long-term outcomes of laparoscopic D3 lymph node (LN) dissection between ligation of the inferior mesenteric artery (IMA) (LIMA) and preservation of the superior rectal artery (SRA) (PSRA) for descending colon cancer using propensity score-matched analysis.
Methods
This retrospective study included 101 patients with stage I-III descending colon cancer who underwent laparoscopic D3 LN dissection with LIMA (n = 60) or PSRA (n = 41) at a single center between January 2005 and March 2022. After propensity score matching, 64 patients (LIMA, n = 32; PSRA, n = 32) were included in the analysis. The primary endpoint was the long-term outcomes, and the secondary endpoint was the surgical outcomes.
Results
In the matched cohort, no significant difference was noted in surgical outcomes, included the operative time, estimated blood loss, number of harvested LNs, number of harvested LN 253, and complication rate. The long-term outcomes were also not significantly different between the LIMA and PSRA groups (3-year recurrence-free survival: 78.7% vs. 88.9%, P = 0.335; 5-year overall survival: 69.8% vs. 63.4%, P = 0.888; 5-year cancer-specific survival: 84.2% vs. 82.8%, P = 0.607). No recurrence of LN metastasis was observed around the IMA root.
Conclusion
Laparoscopic D3 dissection in PSRA was comparable to that in LIMA regarding both short- and long-term outcomes. The optimal LN dissection for descending colon cancer should be investigated in future large-scale studies.
Short-course palliative hypofractionated radiotherapy in patients with poor-prognosis high-grade glioma: quality-of-life outcomes from a prospective phase II study
Authors: Baviskar Yamini , Likonda Beda , Pant Siddharth , Mokal Smruti , Pawar Akash , Dasgupta Archya , Chatterjee Abhishek , Gupta Tejpal
Published: August 2022

Purpose: To report longitudinal quality-of-life (QoL) outcomes in patients with poor prognosis high-grade glioma (HGG) treated with palliative hypofractionated radiotherapy (RT). Methods: Patients with poor-prognosis HGG based on age and performance status were accrued on a prospective study of short course palliative hypofractionated RT delivering 35Gy in 10 fractions over 2 weeks after written informed consent. European Organization for Research and Treatment of Cancer (EORTC) QoL core questionnaire (QLQ-C30) and brain cancer module (BN20) were used in English or validated Indian vernacular languages (Hindi and Marathi) for QoL assessment at baseline (pre-RT), conclusion of RT, 1-month post-RT and subsequently at 3-monthly intervals until disease progression/death. Summary QoL scores were compared longitudinally over time by related samples Friedman’s two-way test. Results: Forty-nine (89%) of 55 patients completed the planned course of hypofractionated RT. Longitudinal QoL data was available in 42 (86%) patients that constitutes the present study cohort. Median age of included patients comprising mainly of glioblastoma (81%) was 57 years with median baseline Karnofsky score of 60. Baseline QoL scores of included patients were significantly worse for several domains compared to historical institutional cohort of HGG patients treated previously with conventionally fractionated RT indicating negative selection bias. QoL scores remained stable for most domains after palliative hypofractionated RT with statistically significant improvements in fatigue (p=0.032), dyspnea (p=0.042) and motor dysfunction (p=0.036) over time. Conclusion: Short-course palliative hypofractionated RT in patients with poor-prognosis HGG is associated with stable and/or improved QoL scores in several domains making it a viable resource-sparing regimen.
Analysis and synthesis of multiview images using wavelets based on voxel patterns
Authors: Saveljev Vladimir
Published: August 2022

Multiview wavelets based on voxel patterns of autostereoscopic multiview three-dimensional (3D) displays are proposed. Direct and inverse continuous wavelet transforms of binary and grayscale multiview images were performed. With modified wavelet coefficients, 3D images with the changed parallax and depth were obtained. Multiview images were displayed using lenticular plates. The visual picture confirms the correctness of all synthesized images. The results can be applied to various types of autostereoscopic 3D displays.
Legacy thinking for long term sustainability: Innovative approach applied in the development of a codesigned co-produced Social Prescribing intervention
Authors: Spencer Llinos Haf , Lynch Mary , Thomas Gwenlli , Edwards Rhiannon Tudor
Published: August 2022

Background
A North Wales housing association offer a social prescription (SP) service within an innovative health and well-being Hub, currently being planned in the Nantlle Valley, Northwest Wales. In line with the requirement of Welsh Government policy, Grŵp Cynefin sought to engage the community in the development of the SP intervention through a co-design and co-production approach.
Method
Drawing from the principles of citizen assembly deliberations and Future Design four focus groups (n = 16) were conducted to develop sustainable strategies, a novel approach was applied to the focus groups. The “Today Groups” deliberated on the well-being of the community today, and the “Legacy Groups” deliberated on the well-being of future generations in developing SP interventions and the well-being Hub as a whole.
Temporal Assessment of River Stages and Discharge Regimes of the Cross River Basin, SE-Nigeria
Authors: EKWERE AZUBUIKE , Kudamnya Ebenezer
Published: August 2022

Hydrological basins commonly experience variations in flow and discharge regimes which are dominantly controlled by prevalent climatic conditions as well as other hydrological parameters. This study is being carried out to establish baseline documentation of water levels and discharge regimes in the Cross River hydrological basin in southeastern Nigeria. The focus of the study is on monitoring sections of the river basin underlain by varied geology and geomorphological settings and the computation of annual means of water levels and discharge with their fluctuations for a period of five years (2010–2014). The data for daily water levels and discharge were recorded at four river gauging stations within the hydrological basin during the study period. Annual mean values for the dataset were computed to establish low and peak flows in the river basin within the period of investigation. Analysis of data by principal component analysis (PCA) shows significant positive correlations for rainfall, mean of water level, and minimum discharge in the upstream and midstream sections of the basin. The mean water level and minimum discharge in the downstream section of the basin indicate no significant correlation with rainfall. Generally, discharge increased from the upstream to the downstream of the basin, and rainfall amounts also increased within the period. Drought analysis by calculation of water-bearing coefficients shows that the basin generally experienced a dry hydrological regime in the first three years of monitoring and a wet regime in the latter years. Variations within the basin over the study period indicate the effects of location, catchment size, and other hydrological parameters.
Prevalence of Osteoporosis among a group of Syrian Women and its Risk Factors
Authors: Alkhani Musab , A.Kadri Saeed , Hammoud Taghrid
Published: August 2022

Background and aim: Osteoporosis is a disease affecting the skeletal system, causing a reduction in bone mass and density, so the bones become fragile and prone to fractures. In addition, osteoporosis affects both men and women, but its prevalence appears widely and strongly in women, especially those after menopause. This disease has many negative impacts on individual and community health in terms of morbidity and mortality. This study aims to determine the prevalence of osteoporosis among a sample of women. By studying demographic factors, medical history, surgical history, gynecological history, and lifestyle, we can determine the risk factors related to it.Materials and Methods: The across-sectional study included a sample of (70) pre and postmenopausal women who had been referred to the densitometry unit in the radiology department at Damascus hospital. Bone mineral density (BMD) at the lumber spine and left femur was assessed by a densitometer using (DXA) technology and, following the World Health Organization criteria for osteoporosis, height and weight were measured. By oral questioning of the patient, detailed demographic information, lifestyle, dietary habits, medical, menstrual, and drug history were recorded in a questionnaire designed for this study. Inclusion criteria included pre and postmenopausal women. Exclusion criteria included females aged less than 18 years and pregnancy. The data was collected between 1/6/2022 and 5/8/2022. Data analysis was performed using the (JMP 14) program.Results:The prevalence of osteoprosis and osteopenia in the study sample were (19%) and (43%), respectively. The mean age in normal BMD women was (48.18±11.76), and the mean age in low BMD women was (54.13±13.71). Osteopenia was significantly associated with age, postmenopausal, number of pregnancies, family history of osteoporosis, low calcium diet, sun exposure, and rheumatoid arthritis, but there was no statistically significant correlation with BMI, menarche, years following menopause, smoking, corticosteroids, thyroxine, or skin color.Conclusions:More than half of the study sample had low BMD, and most of them were postmenopausal. These findings help identify high-risk women and suggest early strategies and serious steps to raise awareness among them and to reduce modifiable risk factors to prevent developing osteoporosis.
Epileptic seizure detection from multivariate sequential signals using Multidimensional convolution network
Authors: Wei Xiaoyan , zhang zhen , Zhou Yi
Published: August 2022

Background
The ability to predict coming seizures will improve the quality of life of patients with epilepsy. Analysis of brain electrical activity using multivariate sequential signals can be used to predict seizures.
Method
Seizure prediction can be regarded as a classification problem between interictal and preictal EEG signals. In this work, hospital multivariate sequential EEG signals were transformed into multidimensional input,multidimensional convolutional neural network models were constructed to predict seizures. several channels segments were extracted from the interictal and preictal time duration and fed them to the proposed deep learning models.
Result
The average accuracy of multidimensional deep network model for multi-channel EEG data is about 94%, the average sensitivity is 88.47%, and the average specificity is 89.75%.
Conclusion
This study combines the advantages of multivariate sequential signals and multidimensional convolution network for EEG data analysis to predict epileptic seizures, thereby enabling early warning before epileptic seizures in clinical applications.
Catenin delta 1 mediates epithelial–mesenchymal transition, proliferation, migration, and invasion of pancreatic cancer via the Wnt/β-catenin pathway
Authors: Huang Xiaobin , Xie Mengyi , Liu Xingyu , Huang Xiaodong , Li Jiayu , Shu Zhihui , Zeng Xin , Yang Yang , Yu Jun , Lan Chuan , Deng Dawei , Li Yong , Zhang Guangnian , Li Jianshui
Published: August 2022

Background: Catenin delta 1 (CTNND1) is upregulated in many tumors and is closely associated with poor prognosis. However, the role of CTNND1 in pancreatic cancer and its underlying mechanisms remain unclear Methods: The expression of CTNND1 in pancreatic cancer and normal tissues in the TCGA and GTEX databases was preliminarily screened and further verified by immunohistochemistry (IHC) and qPCR. Transwell, wound healing, and cell proliferation assays were used to study the effect of CTNND1 on epithelial-mesenchymal transition (EMT), proliferation, migration, and invasion of pancreatic cancer cells. Western blot experiments verified the signaling pathway mediating the effect of CTNND1 on pancreatic cancer progression. The expression of CTNND1 in the TCGA database, clinical pancreatic cancer samples, and pancreatic cancer cells was significantly upregulated. Results: We found that the silent CTNND1 in pancreatic cancer cells significantly inhibited the EMT, proliferation, migration, and invasion of pancreatic cancer cells. In addition, the silencing of CTNND1 in pancreatic cancer cells inhibited the Wnt/β-catenin signaling pathway. LiCl (a Wnt/β-catenin-specific activator) treatment partially restored the EMT, proliferation, migration, and invasion abilities of CTNND1-silenced pancreatic cancer cells. Conclusion: Our research confirmed that CTNND1 can regulate the EMT, proliferation, migration, and invasion of pancreatic cancer through the WNT/β-catenin signaling pathway.
Current Sensor FTC Method for MPTC of Three-Phase Induction Motor Drives without Speed Measurement
Authors: Aghili Soroush , Noori Meisam , Khoshdel Adel , KHAN Ashraf ALI
Published: August 2022

In encoderless Model Predictive Torque Control (MPTC) of three-phase Induction Motor (IM) drives, current sensors can face different electrical or mechanical faults in harsh industrial environments. In this research, single-phase current sensor Fault-Tolerant Control (FTC) method for MPTC of three-phase IM drives without speed measurement using a flux linkage observer and Model Reference Adaptive System (MRAS) algorithm is proposed. In the presented FTC method, Third-Difference (TD) operators, logic circuit module, flux linkage observer, and MRAS algorithm are utilized for fault detection, fault isolation, estimation of stator currents and fluxes, and speed estimation, respectively. In comparison with the conventional current sensor FTC methods, the proposed method can be utilized for encoderless three-phase IM drives. In order to confirm the usefulness and possibility of the proposed encoderless FTC method, experimental studies are performed for a 0.75 kW three-phase IM drive system in different situations. The achieved results demonstrate good performances of the proposed technique during both normal and faulty situations.
Generalized Symmetries in F-theory and the Topology of Elliptic Fibrations
Authors: Hübner Max , Morrison David R. , Schäfer-Nameki Sakura , Wang Yi-Nan
Published: August 2022

We realize higher-form symmetries in F-theory compactifications on non-compact elliptically fibered Calabi-Yau manifolds.
Central to this endeavour is the topology of the boundary of the non-compact elliptic fibration, as well as the explicit construction of relative 2-cycles in terms of Lefschetz thimbles. We apply the analysis to a variety of elliptic fibrations, including geometries where the discriminant of the elliptic fibration intersects the boundary.
We provide a concrete realization of the 1-form symmetry group by constructing the associated charged line operator from the elliptic fibration.
As an application we compute the symmetry topological field theories in the case of elliptic three-folds, which correspond to mixed anomalies in 5d and 6d theories.
TÜRKİYE'DE AKTİF YAŞLANMA ENDEKSİNDE 2008-2020 DÖNEMİNDE YAŞANAN DEĞİŞİM: AVRUPA BİRLİĞİ ÜLKELERİ İLE KARŞILAŞTIRMALI BİR DEĞERLENDİRME
Authors: BEŞE CANPOLAT Şebnem , TAŞTI Enver
Published: August 2022

Türkiye’de nüfusun yaşlanmasının, zaman içinde çalışma hayatı, sosyal güvenlik, sağlık ve eğitim alanlarında etkilerinin olması beklenmektedir. Türkiye’de olduğu gibi dünya genelinde yaşlanan nüfusa yönelik olarak bazı tedbirlerin alınması, özellikle beklenen ömrün uzamasıyla birlikte kişilerin ileri yaşlarda da çalışma hayatında tutulması, yaşam kalitelerinin artırılmasına yönelik politikalar önem kazanmıştır. Avrupa Birliği'nde aktif yaşlanma, bir politika aracı olarak kullanılmakta olan Aktif Yaşlanma Endeksi (AYE) tarafından izlenmektedir. Bu çalışmanın temel amacını, Türkiye için AYE ve bu endeksi oluşturan alan endekslerinin ilk kez 2008-2020 dönemi için hem toplam hem de cinsiyet bazında hesaplanması oluşturmaktadır. Mevcut veri kaynaklarının, endeks değerlerinde zaman içinde meydana gelen değişimin incelenmesi ve Türkiye’de yaşlıların potansiyellerini kullanma konusunda gelişmeye açık alanların belirlenmesi de çalışmanın diğer amaçları arasında yer almaktadır. Çalışmanın sonuçlarına göre Türkiye’nin genel AYE puanında son 12 yılda 6,5 puanlık bir artış meydana gelmiştir ve bu ilerleme, özellikle AB ortalamasındaki gelişimle karşılaştırıldığında oldukça olumlu bir değişimi göstermektedir. Genel AYE değerlerinde iyileşmeye katkısı olan alanlar sırasıyla, 11,3 puan ile “sosyal katılım” alanı, 9,7 puan ile “bağımsız, sağlıklı ve güvenli yaşam” alanı ve 6,1 puanlık artış ile “aktif yaşlanma için kapasite ve elverişli ortam” alanı olmuştur. Türkiye’de yaşlı nüfusun yetenek ve potansiyelinden en az yararlanılan ve önlem alınması gereken alanın istihdam alanı olduğu görülmektedir.
On the asymptotical separation of linear signals from harmonics by singular spectrum analysis
Authors:   JetBrains Research, Zenkova Natalia V. , Nekrutkin Vladimir V. ,   St Petersburg State University
Published: August 2022

The general theoretical approach to the asymptotic extraction of the signal series from the additively perturbed signal with the help of singular spectrum analysis (briefly, SSA) was already outlined in Nekrutkin (2010), SII, vol. 3, 297–319. In this paper we consider the example of such an analysis applied to the linear signal and the additive sinusoidal noise. It is proved that in this case the so-called reconstruction errors r_i(N) of SSA uniformly tend to zero as the series length N tends to infinity. More precisely, we demonstrate that max_i |r_i(N)| = O(N^(−1)) if N → ∞ and the “window length” L equals (N + 1)/2. It is important to mention, that the completely different result is valid for the increasing exponential signal and the same noise. As it is proved in Ivanova, Nekrutkin (2019), SII, vol. 12, 1, 49–59, in this case any finite number of last terms of the error series does not tend to any finite or infinite values.
On extremes of PSI-processes and gaussian limits of their normalized independent identical distributed sums
Authors:   St Petersburg State University, Rusakov Oleg V. , Ragozin Roman A. ,   St Petersburg State University
Published: August 2022

We define PSI-process — Poisson Stochastic Index process, as a continuous time random process which is obtained by a manner of a randomization for the discrete time of a random sequence. We consider the case when a double stochastic Poisson process generates this randomization, i. e. such Poisson process has a random intensity. Under condition of existence of the second moment the stationary PSI-processes possess a covariance which coincides with the Laplace transform of the random intensity. In our paper we derive distributions of extremes for a one PSI-process, and these extremes are expressed in terms of Laplace transform of the random intensity. The second task that we solve is a convergence of the maximum of Gaussian limit for normalized sums of i. i. d. stationary PSI-processes. We obtain necessary and sufficient conditions for the intensity under which, after proper centering and normalization, this Gaussian limit converges in distribution to the double Exponential Law. For solution this task we essentially base on the monograph: M.R.Leadbetter, Georg Lindgren, Holder Rootzen (1986) “Extremes and Relative Properties of Random Sequences and Processes”, end essentially use the Tauberian theorem in W. Feller form.
On solutions of the equation of small transverse vibrations of a moving canvas
Authors:   Moscow Aviation Institute (National Research University), Romanenkov Аlexander M.
Published: August 2022

The paper considers a model problem of one-dimensional small transverse vibrations of a canvas moving at a constant speed, which is fixed in a hinged manner. The oscillatory process is described by a linear differential equation of the 4th order with constant coefficients. In the model under consideration, the Coriolis force is taken into account, which leads to the appearance of a term with a mixed derivative in the differential equation. This effect makes it impossible to use the classical method of separating variables. However, families of exact solutions of the oscillation equation in the form of a traveling wave have been constructed. For the initial-boundary value problem, it was established that the solution can be constructed in the form of a Fourier series according to the system of eigenfunctions of the auxiliary problem on beam vibrations. For the considered oscillatory process, the law of conservation of energy is established and the uniqueness of the solution to the initialboundary value problem is proved.
WASH, vulnerability, severity, and the response of urban slum dwellers to the COVID-19 pandemic
Authors: Nguyen Thi Phuoc Lai , Pattanarsi Siwarat
Published: August 2022

Urban slum dwellers lacked water, sanitation, and hygiene (WASH) and health care assistance during the COVID-19 outbreak. This research aimed to investigate the lived experiences of slum dwellers during the COVID-19 pandemic. Data were obtained through 453 questionnaires and 29 semi-structured interviews with community people and organizations from two slum neighbourhoods in Bangkok, Thailand. The results showed that respondents who had no access to WASH perceived the pandemic as more severe (t = −3.807, p < 0.001; df = 451), whereas respondents who had access to WASH had a higher protective intention towards COVID-19 (t = −3.947, p < 0.001; df = 431). However, there are no differences between the two groups in terms of knowledge, practice, vulnerability, perceived self-efficacy, response efficacy, or response cost between accessibility and non-accessibility to WASH. The Structural Equation Modelling (SEM) results showed that the knowledge of slum dwellers drives their current practice (β = 0.456, p < 0.001) and perceived vulnerability (β = 0.180, p < 0.001), wherein the current practice is influenced by their perceived vulnerability (β = 0.163, p = 0.002). Their current practice also influences their perceived self-efficacy (β = 0.314, p < 0.001), response efficacy (β = 0.557, p < 0.001), and severity (β = 0.198, p = 0.003). Their perceived severity affects their protective intention (β = 0.102, p = 0.043) and perceived self-efficacy promotes their protective behaviours (β = 0.308, p < 0.001). Future pandemic prevention programmes should improve the awareness about COVID-19 protection, self-efficacy, and response efficacy through community sensitization.
REFORMA ADMINISTRATIVA DO GOVERNO BOLSONARO: PARA ALÉM DO PATRIMONIALISMO
Authors: Castro de Albuquerque Melo Esaú , Cabral de Albuquerque Neta Barros Terezinha , Beserra Brasileiro Cyntia Carolina
Published: August 2022

Este artigo analisa a reforma administrativa proposta pelo governo Bolsonaro sob o prisma do patrimonialismo. Com o intuito de compreender os objetivos e motivações da proposta de emenda à Constituição, em especial o pensamento político que a fundamenta, abordaremos os aspectos do texto da reforma administrativa que permeiam o patrimonialismo, mas também os que ultrapassam as definições do próprio patrimonialismo. Para tanto, será realizada uma revisão de literatura com relação ao patrimonialismo na ciência política brasileira, uma breve contextualização da reforma administrativa do governo Bolsonaro, bem como uma análise do texto da proposta de emenda à Constituição, levantando os principais pontos que possibilitam uma apropriação de bens e serviços públicos pelo privado. Nos resultados dessas análises, destacamos que a reforma administrativa foi pensada para atender aos interesses do mercado, e não da administração pública em si; constatamos que existem mecanismos presentes na reforma que reforçam e ampliam o modelo patrimonialista na administração pública.
FEMINICÍDIO: DADOS SOBRE A VIOLÊNCIA DE GÊNERO E POSSIBILIDADES DE INTERVENÇÃO DIDÁTICA NO ENSINO DE SOCIOLOGIA
Authors: Borges da Mota Junior Raimundo
Published: August 2022

A presente pesquisa busca apresentar o feminicídio e suas interfaces dentro de intervenções sociológicas. Deste modo, o objetivo geral do estudo foi investigar a violência de gênero a partir de características sociológicas e suas possibilidades de intervenção didática no Ensino de Sociologia no Ensino Médio da educação básica do Brasil. Para tanto foi desenvolvida pesquisa bibliográfica e documental por meio da coleta do indicador de “Casos Novos de Conhecimento Feminicídio” publicados no site de Monitoramento da Política Judiciária Nacional de Enfrentamento à Violência contra as Mulheres, do Conselho Nacional de Justiça (CNJ). Como resultados, evidencia-se que os casos novos de conhecimento de feminicídio entre 2016 e 2020 apresentou variações regionais que apontam aspectos referentes a estes dados, assim como o aumento significativo da morte de mulheres brasileiras vítimas do ódio e aversão ao mero fato de ser mulher. Conclui-se que uma intervenção didática efetiva em ensino de Sociologia, a partir desses dados, podem sensibilizar estudantes do Ensino Médio a uma postura mais crítica.

Palavras-chave: Feminicídio. Indicadores. Violência de gênero. Ensino de Sociologia.
"lado feio" da Belle Époque
Authors: Marinho Ferreira Julio
Published: August 2022

O historiador francês Dominique Kalifa, um especialista em crimes e suas representações na sociedade francesa dos séculos XIX e XX, apresenta nesta instigante obra “A tinta e o sangue” um importante recorte crítico sobre o papel da mídia impressa parisiense do início do século passado para a divulgação dos chamados fait divers ou “fatos diversos”. Esses “fatos” para aquela forma de mídia impressa (jornais, revistas, novelas), seriam os crimes e suas representações, aos quais, a informação veiculada (o relato em si) era sempre posta em cores sanguíneas. Entretanto, se pode pensar que naquele contexto, a ideia de uma “verdade” seria como uma ferramenta moldável e pintada para acentuar ainda mais a violência. Criando, assim, uma palpável atmosfera de medo e terror que visava um nascente público consumidor, cada vez mais ávido por entretenimento.
Sobre as mudanças na conceitografia: papel formal dos valores de verdade
Authors: Bandeira Duarte Alessandro
Published: August 2022

O objetivo do presente artigo é indicar a função que a distinção entre sentido e referência desempenha dentro da perspectiva logicista de Frege. Em particular, a partir da distinção, Frege busca introduzir os valores de verdade como objetos, os quais desempenham um papel central no sistema lógico das Leis básicas da aritmética
Giant Cell Tumor and Giant Cell Reparative Granuloma of Bone of the
Head: CT and MR Imaging Findings
Authors: Li Sheng-Lan , Kong Yong-Gang , Zou You , Yu Xi , Ouyang Huang-Qing , Chen Shi-Ming , Deng Yu-Qin
Published: August 2022

Background:

This study aimed to determine the features and differentiation of Giant Cell
Reparative Granuloma (GCRG) and Giant Cell Tumor (GCT) of the head on CT and MRI.

Methods:

This retrospective study included six patients with histopathology-confirmed head GCRG
and 5 patients with histopathology-confirmed head GCT. All images were independently reviewed
by two radiologists. The growth pattern, bone changes, MRI signal intensity, enhancement patterns
and other image features were recorded. All patients received CT scans and MR images.

Results:

All the lesions were located centrally in the bone. Osteolytic bone destruction and expansive
growth patterns were observed on CT images. Four of six cases broke the cortical bone with
residual cortical bone, and the last two showed a thin cortex in GCRG. Five cases broke the cortical
bone with residual cortical bone in GCT. There were enhancing septations in GCT lesions on contrast-
enhanced T1-Weighted Images (T1WI) while enhancing septations were not present in GCRG
cases. The size of GCT lesions was larger than that of GRCG. GCRG and GCT showed iso-low signals
on T1WI and iso-high signals on T2-Weighted Images (T2WI). There was a case with cystic or
necrotic lesions in each of the two types of lesions. Osteolytic bone destruction and expansive
growth patterns were observed in GCTs and GCRGs.

Conclusion:

The size of the GRCG lesion was smaller than that of the GCT. The presence of enhancing
septations and the size of the lesion may distinguish GCTs from GCRG.
A Review on the Syntheses and Applications of the 5H-chromeno[2,3-
b]pyridines
Authors: Ramazani Ali , Rezayati Sobhan , Kiani Mohammad Taghi
Published: August 2022

5H-Chromeno[2,3-b]pyridine derivatives are a series of the most important compounds of
chromenes with industrial, biological, and medicinal properties. These compounds are known as the
privileged medicinal scaffold and can be synthesized by different methods such as multicomponent reactions (MCRs), Multicomponent coupling reactions (MCCRs), pot, atom, and step economy (PASE).
In this review article, we have focused on the significant reactions for the syntheses and applications of
5H-chromeno[2,3-b] pyridines, including two-component reactions, three-component reactions, four component reactions, and multi-step reactions. This review is expected to serve as a useful conceptual
overview and inspire the next generation to develop the different strategies for the preparation of 5H Chromeno[2,3-b] pyridine derivatives