bluuebunny/crossref_metadata_2025 huggingface dataset:
Retinal Vascular Lesions in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Authors: Orfanidou Myrsini , Ntenti Charikleia , Evripidou Kleo , Mataftsi Asimina , Goulas Antonis , Polyzos Stergios A.
Published: July 2023

Background: This systematic review and meta-analysis aimed to summarize and compare data on retinal vascular lesions between patients with nonalcoholic fatty liver disease (NAFLD) and individuals without the disease. Methods: Search was performed in PubMed, Scopus and Cochrane Library, complemented by handsearching (PROSPERO ID: CRD42022345558). Thirty-six studies comprising 24,985 individuals (12,387 NAFLD patients and 12,598 controls) were selected for the meta-analysis. Results: Apart from retinopathy, no study with a different type of retinal vascular lesion was retrieved. Overall, there was no significant difference in the presence of retinopathy in NAFLD patients compared to controls (Odds Ratio (OR) = 1.20; 95% Confidence Interval (CI): 0.91–1.59). Heterogeneity among studies was high (I2 = 93%; p < 0.00001), while Egger’s test revealed no publication bias (p = 0.60). However, subgroup analysis showed positive association between retinopathy and NAFLD in type 1 diabetes mellitus (T1DM) (OR = 2.35; 95% CI: 1.53–3.60), but not in type 2 diabetes mellitus patients. Meta-regression analysis exploring potential confounders revealed no significant association. Conclusions: The presence of retinopathy was not overall different between individuals with and without NAFLD; however, T1DM patients with NAFLD had higher rates of retinopathy compared to T1DM patients without NAFLD, a finding warranting further research to show whether NAFLD may predict retinopathy in T1DM patients.
Cell-in-Cell Structures in Gastrointestinal Tumors: Biological Relevance and Clinical Applications
Authors: Druzhkova Irina , Ignatova Nadezhda , Shirmanova Marina
Published: July 2023

This review summarizes information about cell-in-cell (CIC) structures with a focus on gastrointestinal tumors. The phenomenon when one cell lives in another one has attracted an attention of researchers over the past decades. We briefly discuss types of CIC structures and mechanisms of its formation, as well as the biological basis and consequences of the cell-engulfing process. Numerous clinico-histopathological studies demonstrate the significance of these structures as prognostic factors, mainly correlated with negative prognosis. The presence of CIC structures has been identified in all gastrointestinal tumors. However, the majority of studies concern pancreatic cancer. In this field, in addition to the assessment of the prognostic markers, the attempts to manipulate the ability of cells to form CISs have been done in order to stimulate the death of the inner cell. Number of CIC structures also correlates with genetic features for some gastrointestinal tu-mors. The role of CIC structures in the responses of tumors to therapies, both chemotherapy and immunotherapy, seems to be the most poorly studied. However, there is some evidence of involvement of CIC structures in treatment failure. Here, we summarized the current literature on CIC structures in cancer with a focus on gastrointestinal tumors and specified future perspectives for investigation.
Does the Perceived Effectiveness of Voluntary Conservation Programs Affect Household Adoption of Sustainable Landscaping Practices?
Authors: Zhang Xumin , Khachatryan Hayk
Published: July 2023

State and local governments have implemented voluntary and mandatory programs to conserve and protect natural resources in and around urban developments. Even though the long-term environmental benefits are apparent, convincing homeowners to adopt sustainable landscapes with less water and chemical use is challenging. An important consideration from the successful policy implementation point of view is that homeowners have different environmental attitudes, which can be the determining factor that influences their adoption intentions of sustainable landscaping practices. This study assesses whether homeowners’ environmental attitude is a statistically significant predictor of sustainable landscape adoption intention. Moreover, homeowners’ perception of the effectiveness of the voluntary environmental programs may be influenced by their environmental attitudes and impose mediating effects on sustainable landscape adoption intentions. We also examine whether homeowners’ perceived effectiveness of voluntary environmental programs has a mediating effect on the adoption decision. The Value-Belief-Norm hierarchical model framework is utilized to examine both effects. The results revealed that homeowners’ pro-environmental attitudes influence their perceived effectiveness of voluntary programs and their sustainable landscape adoption intentions. The combined influence accounts for 13.6% of homeowners’ adoption intention. Homeowners’ personal norms also affect their perceived effectiveness of voluntary programs (9% variance explained), and the mediating effect of the perceived effectiveness of voluntary programs has an amplifying effect and positively influences the adoption intention. The implications for policymakers in the realm of landscape conservation programs are discussed.
The Value of Agricultural Areas: An Estimation Model of the Area to the Southeast of the City of Bari
Authors: Carbonara Sebastiano , Stefano Davide , Fischetti Michele , Della Spina Lucia
Published: July 2023

The role of agricultural activities in countries with mature economies suggests, on the one hand, the traditional role of producing foodstuffs and dietary fibers; on the other, it speaks to the offering of landscape, cultural, recreational, and environmental services. The member states of the European Union have for some time derogated the control of agricultural processes to EU decision-making, within an overarching vision that recalls both roles of this primary activity. The COVID-19 pandemic and the Russia–Ukraine military crisis have heightened the urgency to protect national agricultural production and guarantee minimum levels of agricultural provisions. In Italy, this orientation clashes with practices of unauthorized construction, favored by policies of “building amnesties”, and the pressure exercised on urban growth that, particularly in fringe areas, modifies the mercantile nature of agricultural lands. This paper examines the theme in operative terms, analyzing an urban fringe in the city of Bari. The use of multiple regression analysis, applied to the agricultural land market, evidenced how prices in these areas are clearly impacted by their potential transformation into buildable terrains, even when urban plans do not foresee this use.
Where Will Threatened Aegle marmelos L., a Tree of the Semi-Arid Region, Go under Climate Change? Implications for the Reintroduction of the Species
Authors: Waheed Muhammad , Haq Shiekh Marifatul , Arshad Fahim , Jameel Muhammad Azhar , Siddiqui Manzer H. , Bussmann Rainer W. , Manshoor Nabeel , Alamri Saud
Published: July 2023

The conservation of threatened species and the restoration of ecosystems have emerged as crucial ecological prerequisites in the context of a changing global environment. One such species of significant commercial value is the Bael tree, scientifically known as Aegle marmelos, which is native to semi-arid regions in Pakistan. However, the species faces threats in Pakistan due to overexploitation and changing land use. To support sustainable production practices and agricultural planning, it is important to investigate how climate change has affected the geographic distribution of Aegle marmelos. Additionally, the impact of climate change on its frequency and distribution remains uncertain. To address these concerns, we employed species distribution modeling techniques using MaxEnt and GIS to predict the present and future distribution of favorable habitats for Aegle marmelos. Based on our findings, several key bioclimatic variables were identified as significant influencers of Aegle marmelos distribution. These variables include soil bulk density (bdod), isothermality (bio03), precipitation during the warmest quarter (bio18), and mean temperature during the wettest quarter (bio08). Currently, the potential suitable habitat for Aegle marmelos spans an area of approximately 396,869 square kilometers, primarily concentrated in the regions of Punjab, Khyber Pakhtunkhwa, and Balochistan in Pakistan. The habitats deemed highly suitable for Aegle marmelos are predominantly found in upper and central Punjab. However, if climate change persists, the suitable habitats in Pakistan are likely to become more fragmented, resulting in a significant shift in the overall suitable area. Moreover, the distribution center of the species is expected to relocate towards the southeast, leading to increased spatial separation over time. The results of this research significantly contribute to our understanding of the geo-ecological aspects related to Aegle marmelos. Furthermore, they provide valuable recommendations for the protection, management, monitoring, and sustainable production of this species.
Abducted Child’s Best Interests versus the Theoretical Child’s Best Interests: Australia, New Zealand and the Pacific
Authors: Henaghan Mark , Poland Christian , Kong Clement
Published: July 2023

A recent trend can be seen in jurisprudence concerning the Hague Convention on the Civil Aspects of International Child Abduction, at least in the Australasia/Pacific region. Courts are now more mindful of the abducted child in particular and will investigate the true impacts of returning the child to determine what is in their best interests, particularly in cases of domestic violence. This is a departure from the long-standing emphasis on returning abducted children promptly to their country of habitual residence, after which the courts of that country will make the final decision, because it is generally in the best interests of children to deter child abduction. This article compares various jurisdictions’ approaches with the lens of whether the courts are preferring the particular child over the ‘theoretical’ child.
Enhancing sEMG-Based Finger Motion Prediction with CNN-LSTM Regressors for Controlling a Hand Exoskeleton
Authors: Vangi Mirco , Brogi Chiara , Topini Alberto , Secciani Nicola , Ridolfi Alessandro
Published: July 2023

In recent years, the number of people with disabilities has increased hugely, especially in low- and middle-income countries. At the same time, robotics has made significant advances in the medical field, and many research groups have begun to develop low-cost wearable solutions. The Mechatronics and Dynamic Modelling Lab of the Department of Industrial Engineering at the University of Florence has recently developed a new version of a wearable hand exoskeleton for assistive purposes. In this paper, we will present a new regression method to predict the finger angle position of the first joint from the value of the sEMG of the forearm and the previous position of the finger itself. To acquire the dataset necessary to train the regressor a specific graphical user interface was developed which was able to acquire sEMG data from a Myo armband and the finger position from a Leap Motion Controller. Two long short-term memory (LSTM) models were compared, one in its standard configuration and the other with a convolutional layer, yielding significantly better performance for the second one, with an increase in R2 coefficient from an average value of 0.746 to 0.825, leading to the conclusion that a convolutional layer could increase performance when few sensors are available.
Anomaly Detection of Underground Transmission-Line through Multiscale Mask DCNN and Image Strengthening
Authors: Kim Min-Gwan , Jeong Siheon , Kim Seok-Tae , Oh Ki-Yong
Published: July 2023

This study proposes an integrated framework to automatically detect anomalies and faults in underground transmission-line connectors (UTLCs) with thermal images because anomaly detection of underground transmission-line connectors (UTLCs) plays a critical role in power line risk management. The proposed framework features three key characteristics. First, the measured thermal images were preprocessed through z-score normalization and image strengthening. Z-score normalization improves the robustness of feature extraction for UTLCs even though noise exists in a thermal image, and image strengthening improves the accuracy of segmentation for UTLCs. Second, a preprocessed thermal image is segmented to detect UTLCs by addressing a multiscale mask deep convolutional neural network (MS mask DCNN). The MS mask DCNN effectively detects UTLCs, enabling anomaly detection only for pixels of UTLCs. Specifically, the multiscale feature extraction module enables the extraction of distinct features of UTLCs and environments, and the skip-layer fusion module concatenates distinct features from the feature extraction module. Furthermore, a half tensor is used to reduce computational resources but maintain the same segmentation accuracy, enhancing the feasibility of the proposed framework in field applications. Third, anomaly detection is performed by addressing the contour method and unsupervised clustering method of DBSCAN. The contour method compensates for the limits of the MS mask DCNN for real-world applications because the neural networks cannot secure perfect accuracy of 100% owing to a lack of sufficient training images and low computational resources. DBSCAN improves the accuracy of diagnosis and ensures robustness to eliminate noise from thermal reflection caused by low-emissivity objects. Field experiments with high-voltage UTLCs demonstrated the effectiveness of the proposed framework. Ablation studies also confirmed that the methods addressed in this study outperform other methods. The proposed framework with a novel automatic non-destructive patrol inspection system would decrease the risks of human casualties during the periodic operation and maintenance of UTLCs, which are currently the most critical concerns.
Anisotropic Tensile and Compressive Strengths of Al-4wt.%Cu Alloy Powder: Part 2—Effect of Dendritic Arm Spacings
Authors: Bonatti Rodrigo S. , Rodrigues João F. Q. , Peixoto Leandro C. , Baldo Rodrigo F. G. , Bortolozo Ausdinir D. , Osório Wislei R.
Published: July 2023

This investigation focuses on the effects of the compaction directions (i.e., transversal and longitudinal) and microstructural arrays (inside the powder utilized to constitute the specimens) on the anisotropic strengths. The initial powders are obtained from the as-cast Al-4 wt.% Cu alloys solidified in two distinct cooling rates, i.e., ~0.5 and 2.5 °C/s. The powder particles are compacted by using 300, 400 and 600 MPa and sintered at 540 °C for 1 h. The compressive and tensile strengths are carried out and the anisotropic strengths are determined. It is found that transverse samples exhibit higher UCS (ultimate compressive strength) and UTS (ultimate tensile strength) than the longitudinal samples. It is also found that the powder compacted in the transversal direction and utilizing powder with finer dendritic arm spacing provides better UCS and UTS results. The novelty in the study concerns the fact that is evidenced in the role of the dendrite spacings concatenated with the compaction pressure and direction upon the mechanical behavior. It is concluded that depending on the compaction level intended or demanded mechanical behavior, the planning in the compaction direction is preprogrammed. Since recycled powder particles from conventional machining, drilling and turning can potentially be utilized to constitute parts and components, the environmentally friendly aspects are associated, and hazardous stages in a manufacturing process are substantially reduced or eliminated.
SARS-CoV-2 Recombinants: Genomic Comparison between XBF and Its Parental Lineages
Authors: Scarpa Fabio , Locci Chiara , Azzena Ilenia , Casu Marco , Fiori Pier Luigi , Ciccozzi Alessandra , Giovanetti Marta , Quaranta Miriana , Ceccarelli Giancarlo , Pascarella Stefano , Ciccozzi Massimo , Sanna Daria
Published: July 2023

Recombination events are very common and represent one of the primary drivers of RNA virus evolution. The XBF SARS-CoV-2 lineage is one of the most recently generated recombinants during the COVID-19 pandemic. It is a recombinant of BA.5.2.3 and BA.2.75.3, both descendants of lineages that caused many concerns (BA.5 and BA.2.75, respectively). Here, we performed a genomic survey focused on comparing the recombinant XBF with its parental lineages to provide a comprehensive assessment of the evolutionary potential, epidemiological trajectory, and potential risks. Genetic analyses indicated that although XBF initially showed the typical expansion depicted by a steep curve, causing several concerns, currently there is no indication of significant expansion potential or a contagion rate surpassing that of other currently active or previously prevalent lineages. BSP indicated that the peak has been reached around 19 October 2022 and then the genetic variability suffered slight oscillations until early 5 March 2023 when the population size reduced for the last time starting its last plateau that is still lasting. Structural analyses confirmed its reduced potential, also indicating that properties of NTDs and RBDs of XBF and its parental lineages present no significant difference. Of course, cautionary measures must still be taken and genome-based monitoring remains the best tool for detecting any important changes in viral genome composition.
Ni(II)-Salophen—Comprehensive Analysis on Electrochemical and Spectral Characterization and Biological Studies
Authors: Ngounoue Kamga Francis Aurelien , Hrubaru Madalina-Marina , Enache Oana , Diacu Elena , Draghici Constantin , Tecuceanu Victorita , Ungureanu Eleonora-Mihaela , Nkemone Stephanie , Ndifon Peter T.
Published: July 2023

New aspects of the Ni(II)-salophen complex and salophen ligand precursor were found during deep electrochemical and optical characterization, as well as biological studies for new pharmacological applications. Physicochemical and spectroscopic methods (1H- and 13C-NMR, FT-IR and UV-Vis, electrospray ionization mass spectroscopy, thermogravimetric analysis, and molar conductance measurements) were also used to prove that the salophen ligand acts as a tetradentate and coordinates to the central metal through nitrogen and oxygen atoms. The electrochemical behavior of the free Schiff salophen ligand (H2L) and its Ni(II) complex (Ni(II)L) was deeply studied in tetrabutylammonium perchlorate solutions in acetonitrile via CV, DPV, and RDE. Blue films on the surfaces of the electrodes as a result of the electropolymerization processes were put in evidence and characterized via CV and DPV. (H2L) and Ni(II)L complexes were tested for their antimicrobial, antifungal, and antioxidant activity, showing good antimicrobial and antifungal activity against several bacteria and fungi.
Hydrogen Evolution Reaction on Ultra-Smooth Sputtered Nanocrystalline Ni Thin Films in Alkaline Media—From Intrinsic Activity to the Effects of Surface Oxidation
Authors: Neumüller Daniela , Rafailović Lidija D. , Jovanović Aleksandar Z. , Skorodumova Natalia V. , Pašti Igor A. , Lassnig Alice , Griesser Thomas , Gammer Christoph , Eckert Jürgen
Published: July 2023

Highly effective yet affordable non-noble metal catalysts are a key component for advances in hydrogen generation via electrolysis. The synthesis of catalytic heterostructures containing established Ni in combination with surface NiO, Ni(OH)2, and NiOOH domains gives rise to a synergistic effect between the surface components and is highly beneficial for water splitting and the hydrogen evolution reaction (HER). Herein, the intrinsic catalytic activity of pure Ni and the effect of partial electrochemical oxidation of ultra-smooth magnetron sputter-deposited Ni surfaces are analyzed by combining electrochemical measurements with transmission electron microscopy, selected area electron diffraction, X-ray photoelectron spectroscopy, and atomic force microscopy. The experimental investigations are supplemented by Density Functional Theory and Kinetic Monte Carlo simulations. Kinetic parameters for the HER are evaluated while surface roughening is carefully monitored during different Ni film treatment and operation stages. Surface oxidation results in the dominant formation of Ni(OH)2, practically negligible surface roughening, and 3–5 times increased HER exchange current densities. Higher levels of surface roughening are observed during prolonged cycling to deep negative potentials, while surface oxidation slows down the HER activity losses compared to as-deposited films. Thus, surface oxidation increases the intrinsic HER activity of nickel and is also a viable strategy to improve catalyst durability.
Human Monkeypox: A Comprehensive Overview of Epidemiology, Pathogenesis, Diagnosis, Treatment, and Prevention Strategies
Authors: Martínez-Fernández Diana Emilia , Fernández-Quezada David , Casillas-Muñoz Fidel Antonio Guadalupe , Carrillo-Ballesteros Francisco Josué , Ortega-Prieto Ana Maria , Jimenez-Guardeño Jose M. , Regla-Nava Jose Angel
Published: July 2023

Monkeypox virus (MPXV) is an emerging zoonotic virus that belongs to the Orthopoxvirus genus and presents clinical symptoms similar to those of smallpox, such as fever and vesicular–pustular skin lesions. However, the differential diagnosis between smallpox and monkeypox is that smallpox does not cause lymphadenopathy but monkeypox generates swelling in the lymph nodes. Since the eradication of smallpox, MPXV has been identified as the most common Orthopoxvirus to cause human disease. Despite MPXV being endemic to certain regions of Africa, the current MPXV outbreak, which began in early 2022, has spread to numerous countries worldwide, raising global concern. As of the end of May 2023, over 87,545 cases and 141 deaths have been reported, with most cases identified in non-endemic countries, primarily due to human-to-human transmission. To better understand this emerging threat, this review presents an overview of key aspects of MPXV infection, including its animal reservoirs, modes of transmission, animal models, epidemiology, clinical and immunological features, diagnosis, treatments, vaccines, and prevention strategies. The material presented here provides a comprehensive understanding of MPXV as a disease, while emphasizing the significance and unique characteristics of the 2022 outbreak. This offers valuable information that can inform future research and aid in the development of effective interventions.
Administration of mRNA-Nanomedicine-Augmented Calvarial Defect Healing via Endochondral Ossification
Authors: Tsou Hsi-Kai , Wu Cheng-Hsin , Chan Long Yi , Kataoka Kazunori , Itokazu Nanae , Tsuzuki Minoru , Hu Hsuan , Zhuo Guan-Yu , Itaka Keiji , Lin Chin-Yu
Published: July 2023

Large-area craniofacial defects remain a challenge for orthopaedists, hastening the need to develop a facile and safe tissue engineering strategy; osteoconductive material and a combination of optimal growth factors and microenvironment should be considered. Faced with the unmet need, we propose that abundant cytokines and chemokines can be secreted from the bone defect, provoking the infiltration of endogenous stem cells to assist bone regeneration. We can provide a potent mRNA medicine cocktail to promptly initiate the formation of bone templates, osteogenesis, and subsequent bone matrix deposition via endochondral ossification, which may retard rapid fibroblast infiltration and prevent the formation of atrophic non-union. We explored the mutual interaction of BMP2 and TGFβ3 mRNA, both potent chondrogenic factors, on inducing endochondral ossification; examined the influence of in vitro the transcribed polyA tail length on mRNA stability; prepared mRNA nanomedicine using a PEGylated polyaspartamide block copolymer loaded in a gelatin sponge and grafted in a critical-sized calvarial defect; and evaluated bone regeneration using histological and μCT examination. The BMP2 and TGFβ3 composite mRNA nanomedicine resulted in over 10-fold new bone volume (BV) regeneration in 8 weeks than the BMP2 mRNA nanomedicine administration alone, demonstrating that the TGFβ3 mRNA nanomedicine synergistically enhances the bone’s formation capability, which is induced by BMP2 mRNA nanomedicine. Our data demonstrated that mRNA-medicine-mediated endochondral ossification provides an alternative cell-free tissue engineering methodology for guiding craniofacial defect healing.
Economic Uses of Salt-Tolerant Plants
Authors: Garcia-Caparros Pedro , Al-Azzawi Mohammed J. , Flowers Timothy J.
Published: July 2023

Climate change is likely to affect the ability of world agricultural systems to provide food, fibre, and fuel for the growing world population, especially since the area of salinised land will increase. However, as few species of plants (less than 1% of all plant species) can tolerate saline soils, we believe it is important to evaluate their potential as crops for salinised soils. We have analysed the economic and potential economic uses of plants that are listed in the database eHALOPH, including the most tolerant species, halophytes. For nine main categories of economic value, we found a total of 1365 uses amongst all species listed in eHALOPH as of July 2022; this number reduced to 918 amongst halophytes. We did not find any obvious differences in rankings between the more tolerant halophytes and the whole group of salt-tolerant plants, where the order of use was medical, followed by forage, traditional medicine, food and drink, fuel, fuelwood, and bioenergy. While many species are potentially important as crops, the effects of salt concentration on their uses are much less well documented. Increasing salt concentration can increase, decrease, or have no effect on the concentration of antioxidants found in different species, but there is little evidence on the effect of salinity on potential yield (the product of concentration and biomass). The effect of salinity on forage quality again varies with species, often being reduced, but the overall consequences for livestock production have rarely been evaluated. Salt-tolerant plants have potential uses in the bioremediation of degraded land (including revegetation, phytoremediation, and extraction of NaCl) as well as sources of biofuels, although any use of saline water for the sustainable irrigation of salt-tolerant crops must be viewed with extreme caution.
The Biosynthesis and Functions of Polyamines in the Interaction of Plant Growth-Promoting Rhizobacteria with Plants
Authors: Dunn Michael F. , Becerra-Rivera Víctor A.
Published: July 2023

Plant growth-promoting rhizobacteria (PGPR) are members of the plant rhizomicrobiome that enhance plant growth and stress resistance by increasing nutrient availability to the plant, producing phytohormones or other secondary metabolites, stimulating plant defense responses against abiotic stresses and pathogens, or fixing nitrogen. The use of PGPR to increase crop yield with minimal environmental impact is a sustainable and readily applicable replacement for a portion of chemical fertilizer and pesticides required for the growth of high-yielding varieties. Increased plant health and productivity have long been gained by applying PGPR as commercial inoculants to crops, although with uneven results. The establishment of plant–PGPR relationships requires the exchange of chemical signals and nutrients between the partners, and polyamines (PAs) are an important class of compounds that act as physiological effectors and signal molecules in plant–microbe interactions. In this review, we focus on the role of PAs in interactions between PGPR and plants. We describe the basic ecology of PGPR and the production and function of PAs in them and the plants with which they interact. We examine the metabolism and the roles of PAs in PGPR and plants individually and during their interaction with one another. Lastly, we describe some directions for future research.
Transcriptomic Profiling of Cold Stress-Induced Differentially Expressed Genes in Seedling Stage of Indica Rice
Authors: Yan Tao , Sun Meng , Su Rui , Wang Xiaozhong , Lu Xuedan , Xiao Yunhua , Deng Huabing , Liu Xiong , Tang Wenbang , Zhang Guilian
Published: July 2023

Cold stress significantly constrains the growth, development, productivity, and distribution of rice, particularly the indica cultivar, known for its susceptibility to cold, limiting its cultivation to specific regions. This study investigated the genes associated with cold responsiveness in the roots of two indica cultivars, SQSL (cold-tolerant) and XZX45 (cold-susceptible), through transcriptome dynamics analysis during the seedling stage. The analysis identified 8144 and 6427 differentially expressed genes (DEGs) in XZX45 and SQSL, respectively. Among these DEGs, 4672 (G2) were shared by both cultivars, while 3472 DEGs (G1) were specific to XZX45, and 1755 DEGs (G3) were specific to SQSL. Additionally, 572 differentially expressed transcription factors (TFs) from 48 TF families, including WRKY, NAC, bHLH, ERF, bZIP, MYB, C2H2, and GRAS, were identified. Gene Ontology (GO) enrichment analysis revealed significant enrichment of DEGs in the G3 group, particularly in the “response to cold” category, highlighting the crucial role of these specific genes in response to cold stress in SQSL. Furthermore, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated pronounced enrichment of DEGs in the G3 group in metabolic pathways such as “Pyruvate metabolism”, “Glycolysis/Gluconeogenesis”, and “Starch and sucrose metabolism”, contributing to cold tolerance mechanisms in SQSL. Overall, this study provides comprehensive insights into the molecular mechanisms underlying cold responses in the indica cultivar, informing future genetic improvement strategies to enhance cold tolerance in susceptible indica rice cultivars.
Synthesis of Multifunctional Polymersomes Prepared by Polymerization-Induced Self-Assembly
Authors: Phan Hien , Cavanagh Robert , Jacob Philippa , Destouches Damien , Vacherot Francis , Brugnoli Benedetta , Howdle Steve , Taresco Vincenzo , Couturaud Benoit
Published: July 2023

Polymersomes are an exciting modality for drug delivery due to their structural similarity to biological cells and their ability to encapsulate both hydrophilic and hydrophobic drugs. In this regard, the current work aimed to develop multifunctional polymersomes, integrating dye (with hydrophobic Nile red and hydrophilic sulfo-cyanine5-NHS ester as model drugs) encapsulation, stimulus responsiveness, and surface-ligand modifications. Polymersomes constituting poly(N-2-hydroxypropylmethacrylamide)-b-poly(N-(2-(methylthio)ethyl)acrylamide) (PHPMAm-b-PMTEAM) are prepared by aqueous dispersion RAFT-mediated polymerization-induced self-assembly (PISA). The hydrophilic block lengths have an effect on the obtained morphologies, with short chain P(HPMAm)16 affording spheres and long chain P(HPMAm)43 yielding vesicles. This further induces different responses to H2O2, with spheres fragmenting and vesicles aggregating. Folic acid (FA) is successfully conjugated to the P(HPMAm)43, which self-assembles into FA-functionalized P(HPMAm)43-b-P(MTEAM)300 polymersomes. The FA-functionalized P(HPMAm)43-b-P(MTEAM)300 polymersomes entrap both hydrophobic Nile red (NR) and hydrophilic Cy5 dye. The NR-loaded FA-linked polymersomes exhibit a controlled release of the encapsulated NR dye when exposed to 10 mM H2O2. All the polymersomes formed are stable in human plasma and well-tolerated in MCF-7 breast cancer cells. These preliminary results demonstrate that, with simple and scalable chemistry, PISA offers access to different shapes and opens up the possibility of the one-pot synthesis of multicompartmental and responsive polymersomes.
Comparison of Cavitation in Two Axial-Flow Water Jet Propulsion Pumps
Authors: Xu Zipeng , Lai Huanxin
Published: July 2023

To investigate the appropriate design method of the water jet pump, numerical simulations are carried out to compare the cavitation in two pumps designed by the streamline method and the blade load method. Based on a brief description of the design methods, the internal flow fields and cavitation in the two axial flow water jet propulsion pumps are studied by using the SST k−ω turbulence model and barotropic law cavitation model. The cavitation location, disturbance velocity field, blade load, and their variations with the cavitation number are analyzed. The results show that the pump designed by the blade load method has a smaller cavitation bubble than the pump designed by the streamline method. With the decrease of cavitation number, the vapor bubbles first appear at the blade tip of the leading edge and then extend from the leading edge to the trailing edge. The bubble thickness and the area of the low pressure on the suction surface also increases. A whirl in the disturbance velocity is observed, which turns the direction of incoming flow to the cavitation area. Furthermore, the head drop of water jet pump is related to the decrease of blade load. The results also show that at the point of cavitation number equal to 0.319, an unexpected peak of head in the pump designed by the streamline method is observed, which indicates an unstable working point for the pump. If the priorities are anti-cavitation performance and high efficiency at the design condition, the blade load method is the first choice to design pumps. While the streamline method should be adopted if high efficiency at large flow rates is preferred.
A Study on the Funerals of the Han Buddhist Monks of Lingnan during the Late Qing Dynasty via the Haichuang Temple in Guangzhou
Authors: Wang Ronghuang , Chen Wanqing
Published: July 2023

The funeral protocol of Buddhist monks is an important part of the rituals of Han Buddhism. The monks’ funeral rituals were recorded in detail in the Monastic Rules (清规) of Chan. The funeral of Chinese Buddhism monks after the Song Dynasty was known through the records of Monastic Rules. However, how it is concretely practiced is unknown. In the late Qing Dynasty, Westerners who came to China out of curiosity about the rituals of Han Buddhism recorded the process and details of the funerals of the monks in the temples they visited, among which Haichuang Temple (海幢寺) in Guangzhou ranks first. The funerals of the monks at Haichuang Temple in the late Qing Dynasty inherited the tradition of Chan funeral culture from the Song Dynasty. Meanwhile, the degradation into secular funeral culture appeared. Influenced by the secular funeral culture in Lingnan (岭南), the tombs of the monks in Chan Temples there, among them, Haichuang Temple is listed as a typical example, showed a trend toward the Shanshou Tomb (山手墓) in the early Qing Dynasty. In the late Qing Dynasty, some of the ancestral tomb-pagodas (祖师墓) in Lingnan Chan Temples abandoned the traditional form of pagodas completely and were almost the same as the Shanshou Tombs. The degradation of the funeral culture of Han Buddhism in the late Qing Dynasty reflects the declining trend of Buddhism.
PENGARUH PEER GRUP EDUCATION TERHADAP TINGKAT PENGETAHUAN LANSIA TENTANG KETASIDOSIS DIABETIKUM DI POSBINDU LANSIA SAKURA KELURAHAN PLESUNGAN KABUPATEN KARANGANYAR
Authors: Windyastuti Erlina , Mardiyah Siti
Published: July 2023

Diabetes Mellitus (DM) merupakan salah satu penyakit dengan pengobatan jangka Panjang dan seumur hidup. DM merupakan salah satu penyakit sistemik yang mampu memunculkan komplikasi. Salah satu komplikasi yang muncul apda penderita DM adalah Ketoasidosisi Diabetik. Ketoasidosis diabetik (KAD) merupakan komplikasi akut diabetes melitus tipe 1 yang ditandai dengan dehidrasi, kehilangan elektrolit, asidosis dan disebabkan oleh pembentukan keton yang berlebihan.  Keadaan ini merupakan gangguan metabolisme yang paling serius dan mengancam jiwa. Tujuan penelitian ini adalah menganalisis pengaruh pendidikan kesehatan peer gorup education terhadap tingkat pengetahuan Ketoasidosis Diabetikum pada lansia DM di Posbindu Lansia Sakura di wilayah Kerja Puskesmas Gondangrejo. Responden lansia berjumlah 25 orang. Uji statistic dengan menggunakan Wilcoxon diperoleh nilai p value = 0,01. Nilai p value = 0,01 lebih kecil dari alpha 0,05 berarti ada pengaruh pendidikan kesehatan peer gorup education terhadap tingkat pengetahuan Ketoasidosis Diabetikum pada penderita DM di Posbindu Lansia Sakura di wilayah Kerja Puskesmas Gondangrejo. Hasil penelitian ini dapat menambah menambah informasi bagi perawat dalam penatalaksanaan peningkatan pengetahuan Ketoasidosis Diabetikum melalui pendidikan kesehatan peer gorup education.

 Diabetes Mellitus (DM) is a disease with long-term and lifelong treatment. DM is a systemic disease that can cause complications. One of the complications that arise in DM patients is diabetic ketoacidosis. Diabetic ketoacidosis (DKA) is an acute complication of type 1 diabetes mellitus which is characterized by dehydration, loss of electrolytes, acidosis and is caused by excessive formation of ketones. This condition is the most serious and life-threatening metabolic disorder. The purpose of this study was to analyze the effect of peer group health education on the level of knowledge of diabetic ketoacidosis in elderly DM at the Elderly Sakura Posbindu in the working area of the Gondangrejo Health Center. Elderly respondents totaled 25 people. Statistical test using Wilcoxon obtained p value = 0.01. The p value = 0.01 is smaller than alpha 0.05, meaning that there is an influence of peer group education health education on the level of knowledge of diabetic ketoacidosis in DM sufferers at the Elderly Sakura Posbindu in the working area of the Gondangrejo Health Center. The results of this study can add additional information for nurses in the management of increased knowledge of diabetic ketoacidosis through peer group education health education.
PENGARUH PENDIDIKAN MENGGUNAKAN VIDEO GAME DEDIMIA TERHADAP UPAYA PENCEGAHAN KEPUTIHAN PADA KEHAMILAN DI BALAI KESEHATAN GAMBIRSARI SURAKARTA
Authors: Rohmatika Dheny , Apriani Arista , Ernawati E
Published: July 2023

Anemia kehamilan adalah keadaan ibu dengan kadar hemoglobin di bawah 11 g% pada trimester pertama dan ketiga, atau kadar hemoglobin di bawah 10,5 g% pada trimester berikutnya, menyebabkan ruam, berat lahir rendah, pengangkatan janin, kondisi medis ibu seperti kemampuan keselamatan yang terhambat, batas kerja yang berkurang, dan peningkatan risiko penyakit jantung. Salah satu cara untuk mencegah terjadinya anemia pada masa kehamilan adalah dengan memberikan informasi melalui media yang efektif. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pendidikan menggunakan video game DEDIMIA (Lokasi awal kelemahan) terhadap upaya pencegahan keputihan pada kehamilan di Balai Kesehatan Gambirsari Surakarta. Pemeriksaan ini merupakan eksplorasi kuantitatif dengan rencana penelitian percobaan dengan rencana pra-eksplorasi, prosedur pengujiannya adalah pemeriksaan lengkap. Jumlah sampel penelitian ini adalah 30 responden. Instrumen penelitian menggunakan kuesioner pengetahuan dan Analisa data menggunakan uji Wilcoxon. Berdasarkan analisis uji Wilcoxon dapat ditarik kesimpulan bahwa terdapat perbedaan antara tingkat pengetahuan sebelum dan sesudah perlakuan (p-Value 0,000). Oleh karena itu dapat diduga bahwa sebenarnya diterima adanya pengaruh pemberian rekaman EDEMIA pada ibu hamil dalam upaya mencegah keputihan pada kehamilan. 

Weakness of pregnancy is a state of a mother with a hemoglobin level under 11 g% in the first and third trimesters, or a hemoglobin level under 10.5 g% in the subsequent trimester, causing rashness, low birth weight, fetus removal, maternal medical conditions like hindered safe capability, diminished work limit, and expanded chance of coronary illness. One way to prevent the effects of anemia during pregnancy is to provide information through effective media. The point of the review was to decide the impact of schooling utilizing video activity DEDIMIA (early location of frailty) on endeavors to forestall paleness in pregnancy at the Gambirsari Wellbeing Center in Surakarta. This examination is a quantitative exploration with trial research plan with pre-exploratory plans, the testing procedure is complete inspecting. The example in this study were 30 respondents. Instrument of research used quessionare of knowledge and data analysed used Wilcoxon test. Based on the Wilcoxon test analysis, it is possible to draw the conclusion that there is a difference between the level of knowledge before and after treatment (p-Value 0.000). Accordingly it tends to be presumed that genuinely it is accepted that there is an impact of giving EDEMIA recordings to pregnant ladies on endeavors to forestall paleness in pregnancy.
UPAYA PENURUNAN TINGKAT DISTRESS ANAK TODDLER SAAT PEMASANGAN INFUS DENGAN MENGGUNAKAN KOMBINASI TERAPI MUSIK DAN PARENTAL HOLDING
Authors: Dwi Lestari Puji Utami Ratih , Ulfa Alfiatun Nuriyah Nela
Published: July 2023

Hospitalisasi merupakan pengalaman yang tidak menyenangkan bagi anak dan menimbulkan stress pada anak. Tindakan pemasangan infus menyakitkan bagi anak dan menimbulkan distress. Salah satu tindakan untuk mengurangi distress anak dengan menerapkan kombinasi terapi musik dan parental holding. Penelitian ini bertujuan untuk mengetahui tingkat stress anak pada saat pemasangan infus setelah diberikan kombinasi terapi musik dan parental holding dengan desain penelitian Post Test Only Control Group Design. Hasil uji Mann Whitney pada 38 sampel menunjukkan p value = 0,027, dimana kelompok kombinasi terapi musik dan  parental holding mampu menurunkan tingkat distress dengan rata-rata penurunan 15,53 sedangkan kelompok parental holding hanya mampu menurunkan tingkat distress dengan rata-rata 23,47. Disimpulkan bahwa kombinasi terapi musik dan parental holding lebih efektif dalam proses penurunan tingkat distress anak usia toodler selama prosedur pemasangan infus.

 

Hospitalization is an unpleasant experience for children and causes stress in children. The act of inserting an infusion is painful for the child and causes distress. One of the measures to reduce children's distress is by implementing a combination of music therapy and parental holding. This study aims to determine the stress level of children at the time of infusion after being given a combination of music therapy and parental holding with the Post Test Only Control Group Design research design. The results of the Mann Whitney test on 38 samples showed a p value = 0.027, where the combination of group of music therapy and parental holding was able to reduce the level of distress with an average decrease of 15.53, while the parental holding group was only able to reduce the level of distress with an average of 23.47. It was concluded that the combination of music therapy and parental holding was more effective in reducing the distress level of toddlers during infusion procedures.
Assessing Faculty Salary Equity
Authors: Allard Celia
Published: July 2023

What is salary equity? How can one show that it does or does not exists? What statistical techniques are appropriate for negotiation or litigation? Questions such as these periodically arise in the college or university setting, particularly with regard to the salaries of continuing academic faculty, which are often determined through loosely defined policies and procedures. When university administrators demand answers, institutional research personnel suddenly find themselves enmeshed in the nontrivial task of salary equity analysis.
HUBUNGAN KUALITAS TIDUR TERHADAP KECEMASAN PADA LANSIA DI POLI GERIATRIK RSUD INDRASARI RENGAT
Authors: Rahmaniza Rahmaniza , Fadhli Rohmi , Nazarudin Etin , Harlia Putri Triyana
Published: July 2023

Lansia merupakan tahapan terakhir dalam perkembangan manusia. Seiring dengan bertambahnya usia, terjadi penurunan fungsi tubuh pada lansia, baik fisik, fisiologis maupun psikologis. Masalah psikologis yang sering terjadi pada lansia adalah kecemasan. Rasa cemas yang dialami oleh lansia yang tidak dapat diatasi akan menganggu kualitas tidur lansia. Tujuan penelitian ini untuk mengetahui hubungan kualitas tidur terhadap kecemasan pada lansia di Poli Geriatrik. Penelitian ini menggunakan metode deskriptif korelasional, dengan rancangan survey cross sectional, dengan teknik total sampling. Sampel pada penelitian ini adalah semua lansia yang berobat ke Poli Geriatrik, dengan jumlah sampel 106. Analisa data yang digunakan chi-square test. Hasil penelitian menunjukkan rata-rata lansia mengalami kualitas tidur buruk yaitu 84 orang (79,2%), sedangkan 56 orang (52,8%) lansia mengalami kecemasan sedang. Adanya hubungan antara kualitas tidur terhadap kecemasan pada lansia di Poli Geriatrik RSUD Indrasari Rengat, dengan nilai korelasi p value (0,010). Direkomendasikan kepada lansia : diharapkan lansia tetap aktif melakukan aktivitasnya dan menjaga kesehatan, serta mengurangi rasa stress pada lansia.
FACTORS AFFECTING URBAN CONSUMERS' PURCHASE DECISIONS FOR READY-TO-EAT FOODS: A STUDY IN PULAU PINANG, MALAYSIA
Authors: Mohammad Tajulurrus , Yusop Azni Syazwani , Ahamad Azam Nurul Atiqah
Published: July 2023

In recent times, the popularity of ready-to-eat food has witnessed a significant rise, especially among the urban population. These convenient foods are easily available in supermarkets and can be consumed at any time and from any location. However, there is a lack of understanding about the factors that influence urban consumers' purchase decisions for ready-to-eat foods. To address this knowledge gap, a study was conducted to analyze the impact of price, packaging, safety, and convenience on the purchase decisions of urban dwellers. The study involved 157 respondents aged 18 and above, residing in urban areas of Pulau Pinang, who were selected through convenience sampling methods. Both online and manual questionnaires were utilized to gather data, which was then analyzed using Statistical Package for the Social Sciences (SPSS) version 27 and Microsoft Excel. The study findings suggest that the independent variables, namely price, packaging, safety, and convenience, had a significant and positive impact on urban consumers' purchase decisions. Thus, this study sheds light on critical factors that influence the purchase decisions of urban consumers for ready-to-eat foods.
Kolonialisasi Gelar Haji: Inisiasi Belanda Waspadai Perlawanan Umat
Authors: Hasanah Aldhania Uswatun
Published: July 2023

Kolonialisasi ibadah haji yang dilakukan oleh pemerintah belanda melalui kebijakan serta ordonansi pelaksanaan ibadah haji pada masa penjajahan merupakan bentuk prasangka sosial (Ambiguous), yang berdampak pada kekhawatiran atas perlawanan kolonialisme oleh umat muslim pribumi. Metode yang digunakan dalam penelitian ini adalah dengan menggunakan metode kualitatif deskriptif melalui pendekatan Histografi atau sejarah. Hasil dari penelitian ini menunjukan bahwa dominasi politik haji yang dilakukan oleh kolonial belanda pada masa penjajahan sangat kental, hal ini didasari dengan adanya berbagai regulasi yang dikeluarkan oleh pemerintah belanda yang sangat memberatkan jamaah yang akan melaksanakan ibadah haji ke tanah suci dengan alasan kewaspadaan dan kekhawatirannya tehadap masyarakat pribumi yang berhaji.