bluuebunny/crossref_metadata_2025 huggingface dataset:
Ellagic acid inhibits cell proliferation, migration, and invasion of anaplastic thyroid cancer cells via the Wnt/β-catenin and PI3K/Akt pathways
Authors: Meng Xianglong , Cui Zhihua , Shi Hui , Ma Xiaoru , Li Wanru , Liu Xianjun , Jiang Yang
Published: February 2023

Anaplastic thyroid cancer (ATC) is a rare but lethal human malignant cancer with no known cure. Ellagic acid (EA), a natural plant extract, has shown antitumor activity against multiple cancers; however, its effects on the malignant phenotypes of ATC cells remain unknown. This study aimed to evaluate the effects of EA on proliferation, migration, and invasion of ATC cells and further explore the associated signaling mechanisms. The normal human thyroid cell line Nthy-ori3-1 and ATC cell line BHT-101 were used. Cytotoxicity assay was performed using the Cell Counting kit-8 (CCK-8) assay. Cell proliferation, migration, and invasion assays were performed using the CCK-8 and colony formation, wound healing, and Transwell invasion assays, respectively. Western blotting was used to detect the levels of related proteins. β-catenin nuclear protein levels were measured to evaluate the Wnt/β-catenin pathway. The phosphorylation level of the Akt protein was measured and calculated to evaluate the PI3K/Akt pathway. LiCl and IGF-1 were used as pathway agonists to determine the involvement of the corresponding pathway. The results showed that EA inhibited the proliferation, migration, and invasion of ATC cells. Furthermore, both the Wnt/β-catenin and PI3K/Akt pathways were suppressed by EA treatment, and activation of these two pathways reversed the EA-induced inhibition of the pathological phenotypes of ATC cells. These findings demonstrate that EA inhibits proliferation, migration, and invasion of ATC cells by suppressing the Wnt/β-catenin and PI3K/Akt pathways, suggesting that EA is a potential drug candidate for treating ATC and provides a theoretical basis for further in vivo experiments and clinical applications.
Assessing Non-Revenue Water Reduction Strategies by Water Service Providers in Kenya
Authors: Ernest Ngolo Chea , Kidere Flaura
Published: February 2023

This study assessed the Non-Revenue Water reduction strategies used by Water Service Providers in Kenya. High NRW affects the financial sustainability of many WSPs in Kenya. The objectives of the study are to ascertain the NRW reduction strategies being used and establish the level of NRW reduction strategy implementation. The researcher used mixed methods approach in conducting this study. He also used stratified random sampling to select a sample of 61 companies from a target population of 81 active water companies in Kenya. The research design for this study was both descriptive and analytical in nature. A semi structured questionnaire was sent online to collect both qualitative and quantitative data from the respondents and analysed using SPSS. A reliability test was also done on the research instruments using factor method analysis. Four theories were reviewed during the study and the key ones being the Managerial Efficiency Theory and the Theory of Constraints. The findings of the study confirmed that all the NRW reduction strategies are being used by the water companies in Kenya. However, other strategies are widely used more than others. The findings also revealed that there are various factors that hamper the full implementation of NRW reduction strategies. The study recommends that management should allocate adequate resources and prioritize NRW reduction activities and fully implement NRW reduction strategies. Managers should also develop policies, procedures and build structures that help in implementation of NRW reduction interventions, leverage technology and ensure that the budget making process takes care of all NRW reduction strategies.
IMPLIKASI SERTIFIKAT HALAL PRODUK DALAM SAKRALISASI AGAMA DI INDONESIA
Authors: Fatimah Cindy , Surawan Surawan , Wahdah Nurul
Published: February 2023

Abstract                This paper aims to determine the implications of halal product certification in the sacralization of religion in Indonesia. Halal certification of the product itself is familiar to business people around the world, especially Indonesia. This paper uses a qualitative descriptive approach through a literature review of halal certification practices in Indonesia. The data were obtained from various articles, magazines, books and media about halal certification and related institutions, namely LPPOM MUI (Indonesian Food, Drug and Cosmetics Institute). The results of this study will describe the halal logo certification, its formation, certification stages, and products that must be halal certified. This article also shows that halal certification is related to the sacralization of Indonesian religion. The implications of product halal certification in the sanctity of Indonesian religion, halal certification does not only sanctify a religion, but also provides guarantees, protection, and provides information about the official halal of a product. Halal certification also affects consumer confidence in halal-certified products for consumption because they have the loyalty and legality of the products consumed and used.Keywords: Halal certification; Religion; Indonesia. Abstract Tulisan ini bertujuan untuk mengetahui  implikasi sertifikasi produk halal dalam sakralisasi agama di Indonesia. Sertifikasi halal produk sendiri sudah tidak asing oleh para pebisnis di seluruh dunia, khususnya Indonesia. Tulisan ini menggunakan pendekatan deskriptif kualitatif melalui kajian literatur praktik sertifikasi halal di Indonesia. Adapun data diperoleh dari berbagai artikel, majalah, buku dan media tentang sertifikasi halal dan lembaga terkait, yaitu LPPOM MUI (Lembaga Pangan, Obat dan Kosmetika Indonesia). Hasil penelitian ini akan memaparkan sertifikasi logo halal, pembentukannya, tahap sertifikasi, dan produk yang harus bersertifikat halal. Artikel ini juga menunjukkan bahwa sertifikasi halal berkaitan dengan sakralisasi agama Indonesia. Implikasi sertifikasi halal produk dalam kesucian agama Indonesia, sertifikasi halal tidak hanya menyakralkan suatu agama, tetapi jugamemberikan jaminan, perlindungan, dan pemberian informasi mengenai halal resmi suatu produk. Sertifikasi halal juga mempengaruhi kepercayaan konsumen pada produk bersertifikat halal untuk dikonsumsi karena memiliki loyalitas dan legalitas produk yang dikonsumsi dan digunakan.  Keywords: Sertifikasi halal; Agama; Indonesia.
SOLUSI AL-QUR’AN DALAM MENGATASI BAHAYA HOAKS PADA ERA DIGITAL (PERSPEKTIF TAFSIR AL-MISBAH)
Authors: Ansari Panji , Abdillah Muhammad Torieq
Published: February 2023

Abstract: From time to time hoaxes have always existed and are now increasing due to the massive development and progress of Science and technology. This hoax is very dangerous if left unchecked. The danger of this hoax can cause many social problems, such as hostility and disputes that lead to the division of the people. Therefore, it is necessary to conduct a research study on the Qur'an regarding hoaxes considering that the Qur'an as a guide for Muslims certainly has a significant role in providing guidance to overcome all problems of the people, including the hoaxes. This study uses the literature method with primary sources, namely Tafsir al-Misbah, because this interpretation is more patterned on the social community. So it is suitable to examine the problem of hoaxes which is a social problem. In addition, the position of the author of this interpretation is quite famous and prominent in Indonesia, so the interpretation is easily understood and accepted by the people of Indonesia. The results of this study obtained interesting ideas from the study of QS. al-Hujurat: 6, namely, the Qur'an provides a solution to overcome hoaxes by teaching to be able to tabayun and sort and choose the essence of the news, knowing the disseminator of the report, and the recipient of the information should know about the message received. If every human being is taught the truth, it will be revealed to him. Keywords: Al-Qur’an, Hoax, al-Misbah Interpretation. Abstrak: Dari masa ke masa, fenomena adanya hoaks selalu ada dan kini meningkat akibat adanya perkembangan dan kemajuan ilmu pengetahuan dan teknologi secara masif. Hoaks ini sangat bahaya jika dibiarkan terus-menerus. Bahaya dari hoaks ini dapat menimbulkan banyak masalah sosial seperti permusuhan dan pertikaian yang berujung pada perpecahan umat. Oleh karena itu, perlu diadakan kajian penelitian terhadap Al-Qur‘an mengenai hoaks mengingat Al-Qur‘an sebagai pedoman umat Islam tentunya memiliki peran besar dalam memberikan petunjuk untuk mengatasi segala permasalahan umat termasuk hoaks tersebut. Penelitian ini menggunakan metode kepustakaan dengan sumber primer, yaitu Tafisr al-Misbah disebabkan tafsir ini lebih bercorak pada sosial kemasyarakatan sehingga cocok untuk mengkaji masalah hoaks yang merupakan masalah sosial. Selain itu, kedudukan pengarang tafsir ini cukup terkenal dan terkemuka di Indonesia sehingga penafsirannya pun mudah dipahami dan diterima oleh masyarakat Indonesia. Hasil dari penelitian ini diperoleh gagasan yang menarik dari kajian terhadap QS. al-Hujurat: 6, yaitu Al-Qur‘an memberikan solusi untuk mengatasi hoaks dengan mengajarkan untuk dapat bertabayun dan memilah serta memilih esensi berita, mengetahui penyebar berita, dan penerima berita hendaknya memiliki pengetahuan berita yang diterima. Dengan demikian, jika setiap manusia mengamalkan apa yang telah diajarkan oleh Al-Qur‘an, hoaks yang ada akan sedikit demi sedikit teratasi. Kata Kunci: Al-Qur’an, Hoaks, Tafsir al-Misbah.
Effect of caffeine supplementation during treadmill exercise on hippocampal genes expression levels in adolescent rats
Authors: BAKIR Fatma , ÇEVİK Özge Selin , MÜSÜROĞLU KELOĞLAN Seval , ŞAHİN Leyla
Published: February 2023

Objectives: The usage of caffeine, a psychostimulant that is included in many foods and drinks, is rising, especially among young people. Also, caffeine works as an ergogenic substance during exercise to improve performance, and strength. In this study, our aim was to investigate the effect of caffeine consumption and exercise on hippocampal learning and memory functions in early life.
Methods: Postnatal 28 days old Wistar albino male rats (n = 28) were randomly divided into 4 groups; control group (C), caffeine group (Cf), exercise group (E), caffeine+exercise group (CfE). Caffeine was dissolved in drinking water (0.3 g/L) and the treadmill exercise was applied 3 days a week. Following, the rats were applied to Morris Water Maze Test (MWMT) and open field test. N-methyl-D-aspartate (NMDA) receptors NR2A, NR2B, and brain-derived neurotrophic factor (BDNF) gene expression levels were investigated in hippocampus tissue by RT-PCR.
Results: In MWMT, there was no significant difference in terms of learning and memory functions and hippocampal gene expression levels of the groups (p > 0.05). In the open field test, the time spent in the center was decreased in the CfE group, and the number of entries to the center was decreased in the E and CfE groups compared to the control group (p < 0.05).
Conclusions: We assumed that caffeine given with exercise application caused anxiety behavior but did not affect learning and memory. There is a need for new studies investigating the effect of caffeine on exercise with different doses and durations depending on age.
Monostephanostomum mesospinosum (Digenea: Acanthocolpidae) Infecting the Coastal Trevally Carangoides caeruleopinnatus (Carangiformes: Carangidae) from the Marine Water off Saudi Arabia
Authors: Abdel-Gaber Rewaida , Alotaibi Mashael , Quraishy Saleh Al , Omar Sawsan A. , Elkhadragy Manal F. , Aljawdah Hossam M.A. , Al-Shaebi Esam M.
Published: February 2023

Background: Carangids, like any other fish, can become infected with a variety of external and internal parasites. Little information on parasite infestations in these fish species is known. This study aimed to provide light on parasites that infect caragnids in Saudi Arabia. Methods: A total of 20 Carangoides caeruleopinnatus specimens were collected from the Red Sea (Saudi Arabia) and then examined for the presence of digenetic trematodes. Parasitic species were isolated and studied morphologically by using light microscopic examination and molecularly via the partial sequencing of 18S rRNA and 28S rRNA genes. Result: Only one parasitic species has been identified. This parasite is morphologically and morphometric compatible with previously Monostephanostomum mesospinosum, identified from Carangoides malabaricus in VSK, BOB. Phylogeny revealed that these putative acanthocolpid species nested well within a clade clustering Monostephanostomum species, which along with morphological data, suggests it is a member of the genus Monostephanostomum. Query sequences showed identities of 97.99% and 97.98% for 18S (EF506762.1.1) and 28S rRNA (EF506763.1) of Monostephanostomum nolani, respectively. This study reflects the third account of this genus as endoparasitic taxa of various carangid fish, as well as providing novel DNA data for this species.
Effect of Wheat Varieties and Integrated Nutrient Management Practices on Nutrient Content, Uptake and Soil Nutrient Status
Authors: Kantwa C.R. , Saras P.K. , Vyas K.G. , Chaudhari H.L. , Choudhary R.R. , Patel Sweta A. , Singh S.R.K. , Patel B.J.
Published: February 2023

Background: A field experiment was conducted during two consecutive Rabi (winter) seasons of 2016-17 and 2017-18 at Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar, Gujarat, India to assess the impact of wheat varieties and integrated nutrient management practices on nutrient content and uptake and soil nutrient status. The soil of the experimental plot was loamy sand in texture, low in organic carbon (0.24%), available nitrogen (159 kg/ha) and Zn (0.41 mg/kg), medium in available phosphorus (38.90 kg/ha) and high in available potash (287 kg/ha). Methods: Experiment was laid out in a Factorial RBD with three replications, consist of four wheat varieties viz. GW 273, GW 322, GW 451 and GW 496 and six integrated nutrient management (INM) practices viz. control, 100% RDF, 100% RDF + Azotobacter + PSB, 75% RDF + Azotobacter + PSB, 75% RDF + Azotobacter + PSB + ZnSO4 and 50% RDF + 25% N through FYM + Azotobacter + PSB + ZnSO4. Result: The pooled results indicated that uptake of nitrogen, phosphorus and potassium by grain and straw, grain yield and straw yield were found higher with wheat variety GW 451 as compared to other wheat varieties. Nutrient content in grain and straw was not significantly affected by different wheat varieties. Among nutrient management practices, nitrogen, phosphorus and potassium content, uptake, grain yield and straw of wheat were significantly higher under application of 100% RDF + Azotobacter + PSB. Further, result revealed that different wheat varieties did not bring any significant variation in available nitrogen, phosphorus, potassium, zinc and organic carbon content in soil. Moreover, highest available nitrogen and phosphorus in soil was recorded with the application of 100% RDF + Azotobacter + PSB. However, significantly higher organic carbon and zinc content in soil was observed under 50% RDF + 25% N through FYM + Azotobacter + PSB +ZnSO4.
Psychological Resilience in Children and Adolescents: The Power of Self-Recovery
Authors: YAVUZ Kudret
Published: February 2023

Many children in the world grow up without good enough opportunities under challenging conditions such as poverty, violence, neglect, abuse, family discord and diseases. These conditions hinder the mental, emotional and social development of children and young people, making it difficult for them to reach their potential to become healthy adults. In addition to all these, there are children who can survive even in the most severe conditions and continue their development with health and functionality. Psychological resilience is a resource that protects and develops the psychological well-being of children and adolescents, rather than an invariable, innate feature, it is a dynamic process that can be developed, continuous and shaped by the interaction of the individual with his own internal factors and environmental factors. The aim of this study is to present a review of the literature on resilience research from past to present. The article includes the definition of resilience, the history of resilience research, components of resilience, models, measurement, interventions, and future directions in resilience research. Investments in the development of resilience in children and adolescents will produce health-promoting outcomes that balance individual and community-based psychological well-being throughout life, including positive outcomes and potential improvements.
Factors Affecting Online Infidelity: A Review
Authors: KAYA Mücahit Mustafa , ŞAKİROĞLU Mehmet
Published: February 2023

Online infidelity has been a topic of discussion for the past two decades. Hence, while it is on the agenda of current researches, the associated factors of online infidelity have not yet been sufficiently clarified. The current review examines factors affecting online infidelity in line with Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. In the review the studies were included considering the criteria of (i) being an empirical study, (ii) being written in Turkish or English, (iii) being published in peer-reviewed journals (iv), evaluating at least one factor that may affect online infidelity. Eight studies which include factors affecting online infidelity were examined and the findings of these studies were evaluated. More positive attitudes towards infidelity, lower relationship commitment, higher quality of alternative partners, lower marital quality, higher loneliness, lower relationship satisfaction, higher relationship uncertainty, anxious and avoidant attachment, and being in a strong position were found significantly associated with online infidelity.
Peran Layanan Home Visit pada Pelaksanaan Pembelajaran Tatap Muka Pasca Masa Pandemi Covid-19
Authors: Denikit Nurin Aulia  , Muhammad Arif Maulana  , Mahmuddah Dewi Edmawati
Published: February 2023

Masa pandemi Covid-19 telah menimbulkan efek yang cukup besar dalam perkembangan belajar peserta didik. Dimana guru bimbingan dan konseling pada pelaksanaan pembelajaran tatap muka pasca masa pandemi Covid-19 masih banyak menemukan permasalahan-permasalahan yang terjadi pada siswa. Seperti penurunan prestasi belajar, menurunnya motivasi belajar siswa, kecanduan game online, pergaulan, dan siswa yang masih terbawa dengan kebiasaan pada waktu pembelajaran daring sehingga pada pembelajaran tatap muka siswa masih merasa malas untuk datang ke sekolah. Faktor-faktor tersebut yang menjadi pemicu banyaknya siswa yang membolos. Sehingga guru bimbingan dan konseling memilih layanan home visit sebagai layanan pendukung yang digunakan untuk membantu siswa dalam mencari solusi dan mengatasi permasalahan yang dialaminya. Tujuan penelitian ini adalah untuk mengetahui peran layanan home visit pada pelaksanaan pembelajaran tatap muka pasca masa pandemi Covid-19. Penelitian ini menggunakan metode kualitatif deskriptif dengan teknik studi kasus. Penelitian ini mengambil lokasi di SMK Muhammadiyah 1 Sukoharjo. Hasil penelitian ini menunjukkan bahwa layanan home visit memiliki peran yang cukup besar dalam pengentasan permasalahan yang terjadi pada siswa. Dengan adanya layanan home visit permasalahan-permasalahan siswa bisa segera untuk ditangani dan terentaskan. Sehingga dapat membantu kelancaran dan keberhasilan proses pembelajaran di sekolah.
Konsep Self-actualized Abraham Maslow: Perspektif Psikologi Sufistik
Authors: Annajih Moh. Ziyadul Haq , Sa'idah Ishlakhatus , Taufik
Published: February 2023

Self-actualization is the peak experience in Maslow's hierarchy of needs theory. Maslow's hierarchy of needs consists of physiological needs, the need for a sense of security (safety needs), the need to have affection (social needs), esteem needs, and self-actualization. The purpose of this study is to describe how Maslow's holistic-dynamic theory describes self-actualization and the Sufistic view of the concept of self-actualization. This study employs a qualitative research method in conjunction with a type of literature review. The data collection technique used is documentation. The results of the study show that Sufistic psychology views self-actualization as a peak experience that is not absolute because humans are not just physical, mechanical beings. Ibn 'Arabi views that humans will reach a peak experience when they have abandoned themselves to unite with God (fana'); then humans must experience four levels: Shari'a, Tariqah, essence, and makrifat. In addition, al-Ghazali also emphasized the fulfillment of mashlahah al-'amm as his peak experience.
Trends in Interpretation of EU Data Protection Authorities of Cybersecurity Requirements Under the GDPR
Authors: GĂBUDEANU Larisa
Published: February 2023

One of the main legal requirements for the adopting the GDPR was the technical and organizational security requirements, alongside the transparency and purpose limitation principles. The wide wording mentioned by the GDPR in terms of state-of-the-art security measures has given rise to a series of interpretations both in literature and by the data controllers and data processors. The manner in which national data protection authorities interpret this wording on a case-by-case basis is a good indicator in terms of interpretation, as the authorities look into the specific use case requiring preventive security measures. Thus, this research paper brings additional clarity in the interpretation of this legal requirement in terms of the risks and damages considered relevant for the specific data breach or lack of proper legal requirement implementation, given publicly available information in this respect. Further, the research paper highlights the number of use cases analyzed by different national data protection authorities and the views of each national data protection authority.
Getting Started with Vulnerability Disclosure and Bug Bounty Programs
Authors: PASCARIU Cristian
Published: February 2023

The raise in online platforms and services that organizations around the world offer has grown significantly, ensuring the information security of these platforms is a task of paramount importance. There are challenges in achieving this mainly due to the shortage of skilled security professionals and the growing number of online services that companies offer. This article focuses on the benefits of using Crowdsourcing security programs, such as Vulnerability Disclosure Programs (VDP) and Bug Bounty programs to complement the existing security assessments performed by organizations. These programs provide a way for organizations to better interact with the security community, gain valuable insight into the public security posture, improve the brand image by providing a mechanism in which security researchers can notify the organizations of imminent security risks.
Multiculturalidad en la formación de recursos humanos y ejercicio profesional del área de la salud.
Authors: González Fócil José R. , Fócil González Leticia , González Fócil Roberto C. , Domínguez Aguirre Gloria A.
Published: February 2023

Multiculturalidad en la formación de recursos humanos y ejercicio profesional del área de la salud.
Evaluation of the protective and moisturizing effects of cosmetic formulations for the skin containing extracts with film-forming properties
Authors: Penachin Bruna , Kakuda Letícia , Maia Campos Patrícia
Published: February 2023

The development of formulations that provide efficient film-forming properties is important since film formation can protect the skin and hair from the action of external aggressors, such as pollution. Thus, the aim of this study was to evaluate the film-forming effect of cosmetic formulations for the skin containing extracts of Kappaphycus alvarezii and Caesalpinia spinosa, as well as the use of hemisqualane as an alternative to synthetic silicones. The evaluation of efficacy was performed by biophysical techniques and skin imaging techniques, as well as by a sensorial analysis. Sixteen women, aged 18 to 30 years, participated in the study. The results obtained demonstrated that the presence of the extracts in the formulation enabled the formation of a film that helped maintain skin barrier integrity, reduced desquamation, and improved parameters related to hydration. Finally, the study also showed that there were no significant differences between the formulations containing silicones and hemisqualane, which supports the use of hemisqualane as a more sustainable alternative in cosmetic formulations. Keywords: biopolymer, film-forming effect, hemisqualane, clinical efficacy, cosmetics
Skin care in women after 45 years of age
Authors: Chamczyńska Magdalena , Kuźniak Aleksandra , Jenerowicz Dorota , Żaba Ryszard , Adamski Zygmunt , Polańska Adriana
Published: February 2023

Introduction. Proper skin care, including cleansing, hydration, protection against sun, has meaningful impact on one’s look and function. Skin care should always be adjusted to its needs that changes through years of life.Aim. The aim of the study was to assess the knowledge about skincare at women past 45.Material and Methods. Fifty‑six women participated in this study. The research instrument was a questionnaire, which contained twenty‑seven questions. The questionnaire was put online. Inclusion criteria: age after 45 and female gender.Results. Women past 45 didn't care correctly about their own skin. Their knowledge was not proper considering photoprotection and regular application of cosmetics with UV filters. Women past 45 didn’t have enough knowledge about photoprotection and they didn’t use it adequately. Women with less amount of skin lesions, which was related with skin aging, were more pleased about their appearance than women, who have more skin changes.Conclusions. Women after the age of 45 applied most of all moisturizers and anti‑wrinkle creams in their skincare routine. Women after the age of 45 require more education about how to use photoprotection in the right and effective way. The less skin changes, connected with skin aging, the better frame of mind about skin appearance at women past 45.
The use of cutometer to evaluate the skin elasticity on the face
Authors: Hojan-Jezierska Dorota , Matthews-Kozanecka Maja , Kubisz Leszek
Published: February 2023

This paper presents the possibilities of pre‑treatment instrumental diagnosis assessing the condition of various facial skin areas. Tests which are aimed at determining the elasticity of facial skin were conducted. Analysis of skin parameters in selected facial areas in adults over a wide age range was performed using the Cutometer Dual MPA 580 probe. Parameters R2, R5, R7 were analysed. The following results were obtained: R2 (0.66–0.82) a.u.; R5 (0.60–0.92) a.u.; R7 (0.37–0.52) a.u. On the basis of the other parameters it can be concluded that skin elasticity and an ability to return to its original shape around the eyes, on the cheeks and around the lips is greater in younger patients than in older groups. There were no statistically significant differences within each age group between the right and left sides of the face. The ageing process simultaneously affects the entire facial skin which was confirmed by skin elasticity testing.
Application of botulinum toxin associated with aesthetic surgical crown lengthening in treatment of gummy smile
Authors: Pedron Irineu Gregnanin , Shitsuka Caleb
Published: February 2023

The pursuit of esthetic excellence has become a major goal in the dental treatment. The beauty of the smile is not only constituted by the shape, position and size of the teeth, but also based on the characteristics of the gingival tissue and conformation of the lips, which should be as harmonious as teeth. Gummy smile is one of the complaints of the patients, since such a situation can influence self-esteem. The purpose of this article is to present the case of a patient who presented dentogingival discrepancy and gummy smile, treated by gingivectomy and by application of botulinum toxin.
Effects of mesotherapy treatments on subjective assessment of facial skin in patients aged 40+
Authors: Jarocka Magdalena , Młyńska Monika , Polańska Adriana
Published: February 2023

Introduction. Needle mesotherapy is a procedure that has been known since the 20th century. It involves intradermal or subcutaneous administration of active substances that are responsible for renewal and regeneration. Cyclic punctures performed during the procedure further stimulate the formation of collagen, elastin and hyaluronic acid.Aim. The purpose of the study was to evaluate the effectiveness of needle mesotherapy treatment based on the subjective opinions of patients of aesthetic medicine offices in the Tri‑City area.Material and methods. Questionnaires of our own authorship were used in the study of patients' opinions. The procedure was performed under local anesthesia, using a preparation containing in its composition hyaluronic acid and a mixture of amino acids.Results. Based on the obtained results, it can be concluded that needle mesotherapy treatment is a highly effective procedure that meets the expectations of clients. The main group of people interested in the treatment are women aged 40–45, with a college or post‑secondary education, living in a married couple. The effects of needle mesotherapy include an increase in hydration, improvement in firmness and elasticity, reduction of wrinkles, equalization of skin tone and increased skin smoothness. The increase in skin hydration and skin smoothness are the most visible effects. On average, 2 out of 10 needle mesotherapy treatments may be followed by side effects, which last up to a maximum of 3 days after treatment.Conclusions. Needle mesotherapy is one of the more popular and safe ways to preserve the youthful appearance of the face and neck skin. In the majority of treatments, side effects do not occur or are so minor that patients are able to return to daily life within a short period of time. The vast majority of respondents are satisfied with the results of the procedure performed and express a desire to continue.
Assessment of facial surface tension after CGF Harmony treatment – preliminary report
Authors: Łącka Monika , Komisarek Oskar , Luchowska Anna , Kawałkiewicz Weronika , Matthews‑Brzozowska Teresa
Published: February 2023

Introduction. The aim of the study was to evaluate the usefulness of the Clinical Direct Transmission System device and photographic medical documentation to assess the improvement in the skin of the face and hands before and after a one‑time CGF Harmony treatment.Material and methods. The study, after signing a voluntary informed consent, was attended by 3 patients of the Facial Aesthetics Clinic of the University Center of Dentistry and Specialist Medicine of the limited liability company. in Poznan. Once, in accordance with the procedure, a complex of stem cells and growth factors (CGF Harmony – in liquid and gel form) was administered to the area of the facial skin and the gel skin to the area of the dorsal surface of the hands. The observation period was 12 months, from the moment of the procedure, including control tests at several stages: before the procedure, immediately after administration, and approximately 6 and 12 months after the application.Results. The study showed no statistically significant differences in the surface tension of facial expressive muscles with a single application of CGF Harmony for most of the measurements.Conclusions. The analyzis of the photographic documentation and the subjective assessment of the patients, showed that the treatment turned out to be beneficial in terms of improving the quality of the facial skin and exceptionally beneficial in the area of the skin of the hands, which requires confirmation in further studies with a larger study group. There were no statistically significant changes in the facial expression muscles surface tension after the CGF Harmony procedure.
Polemics around facial aesthetic medicine
Authors: Matthews-Kozanecka Maja , Baum Ewa , Mojs Ewa
Published: February 2023

Facial aesthetic medicine is a young component of aesthetic medicine that raises a lively polemic on a number of issues on both medical and ethical grounds. The main focus of (non‑therapeutic) aesthetics turns to the improvement and correction of the face and neck to get from what is good to an even better, more beautiful, aesthetically pleasing, younger face. However, when qualifying a patient for aesthetic treatments, it is important to approach the issue holistically, to pay attention to all aspects: psychological state, social and cultural conditions and a holistic attitude towards life. Any worrying symptoms should not be underestimated. Thus, the practitioner of aesthetic medicine should always bear in mind two very topical truths of ancient origin: primum non nocere and salus aegroti suprema lex.
Current principles of photoprotection
Authors: Fijak Emilia , Polańska Adriana
Published: February 2023

Solar radiation is an important factor affecting human health. Under the influence of ultraviolet UVR vitamin D is synthesized in the skin, but its negative consequences are the possibility of skin burns, photoaging, damage to cell structures, including the DNA chain, and secondarily carcinogenesis. Protection from sunlight can be provided by using creams with UV filters, clothing with accessories, and avoiding overexposure to the sun. This paper presents the current principles of photoprotection based on current literature data.
The use of platelet-rich fibrin in dental aesthetics
Authors: Tuczyńska Magdalena , Zamaro Martyna , Matthews-Brzozowska Teresa
Published: February 2023

Introduction. Appearance is an important element of both the physical and psychological spheres of a person. Clinicians are increasingly using platelet‑rich fibrin (PRF) in aesthetic medicine procedures. PRF can be used to improve the smile with great success. Aim. The aim of this study is to present the latest reports on the use of platelet‑rich fibrin in smile aesthetics from the last 5 years. Material and methods. Online databases were searched by typing the keyword platelet‑rich fibrin and adding words with treatments used in smile aesthetics. The time interval was defined as between 2017–2022. Results. Twelve scientific articles on the use of platelet‑rich fibrin in bone defect regeneration, gingival recession coverage, bifurcation regeneration and tissue regeneration after tooth extractions were used. Conclusions. Platelet‑rich fibrin is widely used in dentistry and has the added value of being autologous.
Exploring English Skill Problems of Engineering Students for Evaluating Their Needs
Authors: Noprival
Published: February 2023

Despite the existence of many studies on English skills in the classroom context, little scholarly work reports English skill problems for engineering students. To fill this gap,  this current study explores English skill problems of engineering students for evaluating their needs. This study was conducted at a national institute of technology in India. The data were collected through administering questionnaires. The study indicates that the engineering students feel the most difficulty in making presentations individually (speaking). They also have difficulty in listening, especially in understanding lectures. Further, the obstacle in writing reveals that the engineering students more frequently encountered difficulty in transferring information from visual to verbal and using correct punctuation during the writing activity. It is surprising in reading skill that the students do not encounter a big problem in reading. Moreover, they state that reading is very important to success in their courses of study. The findings suggest that although reading is keeping to be taught extensively, the lecturer should foster students more in listening, speaking, and writing skills in the teaching learning process.
A SCIENTOMETRIC ANALYSIS OF ACADEMIC PERFORMANCE DEVELOPMENT: R BIBLIOSHINY
Authors: Septian Cahya Azhari  , Fadjarajani Siti , Muhamad ferdi Firmansyah  , Tita Yuniarti
Published: February 2023

The development of research in the field of education experiences exponential growth every year. This study aims to analyze the development of research on academic performance from 2010-2022. A total of 1906 articles indexed by the PubMed database were analyzed with a scientometric qualitative approach with bibliometric R bibliophily and VosViewer R tools. The results showed a significant development of research on the object of study of academic performance, especially in 2020-2022. From the analysis of several articles, this development was primarily influenced by the covid-19 pandemic. Some authors are categorized as productive writers on this theme, in most of them are from China. The potential for future research by looking at the research keywords of bibliometric analysis results in cluster 1, such as academic functioning, school performance, educational attainment, socioeconomic status, sleep duration, and parental education, is about increasing "student academic performance" which is supported by "school performance", "parental education" and "socioeconomic" families. This research helps compile study topics regarding academic performance and find novelty in subsequent research.
ORAL ASSESSMENT IN TRIGGERING STUDENT HIGHER-ORDER THINKING SKILLS (HOTS)
Authors: Mahendra Eka
Published: February 2023

Students' higher-order thinking skills (HOTS) due to the application of oral Assessment and Assessment are usually compared using experimental research in two separate groups. The experimental group consisted of 31 students, and the control group of 32 students was taken using a simple random sampling technique from a population of 315 students. Students' HOTS data were collected utilizing a test consisting of 5 items tested for validity, and the reliability coefficient was calculated. The collected data were then analyzed using a test (t-test), and the classical assumption test had previously been carried out. It turns out that the HOTS of students who are given an oral assessment is better than the HOTS of students who are given a regular assessment. Even though students are more afraid to face oral Assessment, they consider oral Assessment more beneficial than ordinary Assessment.
COMPUTER-BASED STANDARDIZED TESTING (CBT) SUMMATIVE ASSESSMENT: ONE INSTITUTION EXPERIENCE
Authors: Naila Rajiha  , Rini Setia
Published: February 2023

One tool for measuring the result of learning is the summative assessment using Computer-Based Standardized Testing (CBT). The assessment process and the issues that arise in holding are fascinating to be discussed. This research was focused on: How the CBT final examination test is being implemented in a school in Pati Regency. This study employs descriptive case studies as one of the methods of qualitative research. Interviews, observation, and documentation are the data collection techniques for this study's primary and secondary sources. The researchers used a triangulation data source and triangulation technique to check the data integrity. The authors draw the following conclusions: Students' learning evaluation processes are through various activity procedures, such as simulating, implementing, overseeing evaluations, processing data, and using evaluation results. Moreover, observing student needs and readiness in all forms is an obligation applied in conducting CBT.
Between Philosophical Criticism and Ideological Apologetics (on the Levels of Existence of Human Ideas)
Authors:   Institute of Philosophy, Russian Academy of Sciences, Kara-Murza Alexei A.
Published: February 2023

The article is devoted to the problem of the correlation of Philosophy and Ideol­ogy. The deep opposition of these two phenomena is that Philosophy is critical thinking, while Ideology is apologetic consciousness. Ideologies are also sa­turated with critical invectives against opponents, but this criticism is only a preparatory action before the main act of ideology – the postulation of one’s own indisputability. The declaration of absolute truth is the credo of an Ideolo­gist, not a Philosopher, who understands the unattainability of absolute truth. There are three levels of existence of human ideas. The first is the actual Ideas, breakthrough guesses; this is a personalized level, where each idea is marked by the author. The second level is the space of ideologems, ideological constructions that still retain the memory of their personal authorship, but have already over­grown with a “party” shell. Ideologems are clusters of not creative-authorial, but already secondary, relaying consciousness; these are “ideas – passwords” by which corporations are self-determined and delimited in the public space. Fi­nally, the third level of the existence of ideas is Ideologies, firmly fixed ideologi­cal complexes that have indisputable dogmatics. Ideologies are the final station of the path from “love of truth” to “will to power”.
The Influence of Confucianism on Formation Zeng Guo-fan’s System of Philosophical Views
Authors:   Institute of Philosophy, Saint-Petersburg State University, Konstantinova Ekaterina A.
Published: February 2023

Zeng Guo-fan played an important role in the development of the position of Confucianism in China. The article is devoted to the consideration of the cate­gorical and conceptual apparatus of the philosophical system of Zeng Guo-fan. The thinker found points of contact between his own progressive ideas related to the development of personality and basic Confucian values. For the first time, translations of Zeng Guo-fan’s reflections on the ways of self-improvement of the individual are introduced into scientific circulation, recommendations for daily practical actions. A significant role in the formation and development of Zeng Guo-fan’s philosophical system of views was played by neo-Confucian­ism, namely the “teaching of the heart”, which the thinker analyzed through the prism of his practical life experience. The article presents an analysis of the most significant categories of Confucianism such as humanity, wisdom, conscious­ness/heart, reverence, sincerity, generosity. Zeng Guo-fan in his system of philo­sophical views brings a personality practical values such as diligence, modera­tion, calmness, constancy, lack of laziness, practicality, education.
Understanding the “Vernacular”: Between “Native Chickens”, Architectural “Peculiarity”, and “Living Religiosity”
Authors:   Vladimir State University named after A.G. and N.G. Stoletovs, Arinin Evgenyi I. , Lyutaeva Maria S. ,   Vladimir State University named after A.G. and N.G. Stoletovs, Silantyeva Margarita V. ,   MGIMO University
Published: February 2023

The article explores the development of ideas about the ‘vernacular’ in Linguis­tics, Urban Planning, and Philosophy of Religion. It focuses on ‘living religios­ity’ reflected in personal and group perceptions and practices embedded in lan­guage. This understanding has shown continuity since ancient times, with its first written records as ‘vernaculum’ used by Plautus, Cicero, and Varro to denote ‘home’, ‘native’, and ‘domestic’ as compared to ‘universal’ meaning ‘Roman’. In the Renaissance, the term acquires new connotations. These result from the then-emerging nation-states and the consequent need to translate the Bible into ‘vernacular’ (i.e., common, local) languages, on the one hand, and the ideal­ization of Cicero’s Rome scented with an ‘inexplicable metropolitan aroma’ symbolically inherited by the new centers of influence across the globe – on the other. In the 19th century, researchers introduce the subculture of na­tional ‘folklore’ (or ‘popular wisdom’) identified with a ‘folk religion’ (typical of grass-roots) colliding with an official lofty ‘theological religion’. To over­come the misrepresentation of such ‘folk’ religious manifestations in ethnogra­phy and folklore, scholars formulate the concept of ‘vernacular religion’ aimed to correctly reflect the dynamism of actual religious life, including both ‘ecclesi­astical’ and ‘extra-church’ forms of religiosity. Accordingly, in a bid to avoid the stereotypical juxtaposition of the official vs. popular, or ‘pure’ vs. ‘spoiled’, which is still relevant for such terms as ‘sect’, ‘paganism’, ‘superstition’, ‘rene­gades’, enemies of the ‘dominant religion’, and alike as retaining negative inter­pretations, the authors point out the prospects of using the term ‘private religion’ coined by Alexander Panchenko.
Russia and Europe, Man and History in the Book by Vladimir Kantor “Dostoevsky’s Two Homelands: an Attempt at Comprehension”
Authors:   Gorky Institute of World Literature of the Russian Academy of Sciences, Gacheva Anastasia G.
Published: February 2023

The article is a reflection on the book by the Russian writer and philosopher Vladimir Kantor, which examines the interaction in Dostoevsky’s creative con­sciousness of two historical and cultural streams coming from Russia and Europe, having a single source in Christianity and ultimately converging in the ideal of all-humanity. The relevance of the appearance of this book is shown, which, relying on Dostoevsky and European thinkers, raises the problem of the religious crisis and allows us to reveal the ethical and axiological content of the Russian idea in the aspect of the movement towards a new version of planetarity. The wa­tershed is marked between the historiosophical model based on the idea of the civilizational alienation of Russia and the West to each other, and the vision of Dostoevsky, for whom Russia and Europe are spiritual sisters and co-workers in history, designed to transfer humanity from a state of enmity to a state of brotherhood.
Rammohun Roy and Pyotr Tchaadaev: Philosophical Thought in the Dialogue of the West and the East
Authors:   Penza State University, Skorokhodova Tatiana G.
Published: February 2023

A comparative research of philosophical thought by Rammohun Roy and Pyotr Tchaadaev is presented in the article. At the context of the West – the East inter­action in Modernity, both philosophers became the pioneers of self-discovery and self-knowledge by India and Russia respectively. Based on a juxtaposition of the works by Indian and Russian thinkers, their thought is described as special ‘philosophy of self-finding’ for their own societies in circumstances of the dia­logue between the East and the West. It is formed owing to their reflections on reasons of crisis in their societies and possibilities to overcome one. Philoso­phy of self-finding includes two levels; the first is religious-philosophical, which correlates the being of Indian and Russian societies with the universal Absolute (the building of spiritual vertical). Seen through universalist approach, thinkers’ spiritual traditions (Vedantism of R. Roy and Christianity of P. Tchaadaev) helped to create the realistic knowledge of social life and ways of development in India and Russia. The second level is social-philosophical. Thinkers offer the prece­dents of objective understanding of the West to discover the true reasons of own societies’ backwardness and perspective for their improvement in Modernity.