bluuebunny/crossref_metadata_2025 huggingface dataset:
A study on cisplatin -paclitaxel induced peripheral neuropathy in cancer patients
Authors: C. Umamaheshwari , M. Shanthi , M. Malathi
Published: April 2019

Background: Chemotherapy induced peripheral neuropathy is a significant disability after the treatment of large number of cancers and they have an impact on quality of life. The aim of the present endeavour was to study the cisplatin-paclitaxel induced peripheral neuropathy in patients with lung or ovarian cancerMethods: The study was carried out in the Department of Oncology, Government Rajaji Hospital, Madurai, after obtaining clearance from Institutional ethical committee, Government Rajaji Hospital, Madurai. Thirty newly diagnosed patients suffering from Lung or ovarian cancer attending Oncology department were selected. After satisfying inclusion and exclusion criteria. Patient received injection cisplatin 60 mg/m2 and injection paclitaxel 175 mg/m2. Nerve conduction study was done to assess the peripheral neuropathy. It was done before starting the chemotherapy. Patients with grade 0 neuropathy were included for the study. Nerve conduction study was repeated after each cycle. The time taken to develop peripheral neuropathy was assessed using Cancer Institute - Common Toxicity Criteria version 3.0. The data were analyzed with SPSS statistical software package (Version 16.0 SPSS Inc., Chicago, USA ).Results: There is a statistically significant reduction in sensory nerve (sural) amplitude (SNAP) and latency (p <0.05) indicating significant axonal damage. The time taken to develop peripheral neuropathy was 3 cycles with grade 3/4.Conclusions: In this present study, the neurotoxicity induced by cisplatin-paclitaxel in patients with lung or ovarian carcinoma was observed, so that early intervention can prevent the permanent neurotoxicity.
Assessment of adverse drug reaction profile of the disease-modifying anti-rheumatic drugs at the department of orthopaedics in a tertiary care hospital, Silchar, Assam, India
Authors: Kairi Vijoy S. , Chakravarty Pinaki , Sipani Arun Kumar
Published: April 2019

Background: The mainstay of treatment of Rheumatoid Arthritis (RA) is the use of the disease-modifying anti-rheumatic drugs (DMARDs). Methotrexate, sulfasalazine and hydroxychloroquine are some of the DMARDs which are used in combination for the treatment of RA. The current study was undertaken to assess the adverse drug reactions (ADRs) of DMARDs that are commonly encountered with the treatment of RA.Methods: The present study was designed as a prospective, observational study on newly diagnosed patients with RA. Patients diagnosed with RA above 18 years (excluding pregnant women) of either sex who were prescribed DMARDs in combination were included. ADRs reported spontaneously by the patients and also responses obtained in a questionnaire related to likely ADRs from the patients was recorded in the case record form. Statistical analysis was done using graph pad and p value <0.05 was considered to be statistically significant.Results: A total of 47 patients attending the Outpatient Department of Orthopaedics, Silchar Medical College and Hospital, Silchar, Assam, India were screened for the study. ADRs were monitored up to the last visit on 41 patients excluding the patients who were lost and who were not able to adhere to the treatment. A total of 27 ADRs were reported from 19 ADR forms. Gastrointestinal manifestations were the most common adverse effects of combination DMARDs seen in 10 patients (24.39%). Severity assessment done using modified Hartwig and Siegel scale that showed majority of the ADRs were mild (74.07%).Conclusions: Present study showed that DMARDs are well-tolerated and have an acceptable toxicity profile as majority of ADRs seen were mild. It was however difficult to prevent the occurrence of ADRs. Proper monitoring of therapy is needed for early recognition of ADRs.
Adherence to treatment in patients undergoing dialysis
Authors: V. Rakshitha B. , G. K. Nalini , G. N. Sahana , P. Deepak , Nagaral Jayashree V. , N. Mohith , C. R. Divyashree
Published: April 2019

Background: Chronic Kidney Disease (CKD) is a silent disease that is frequently diagnosed in advanced stages. The prevalence and incidence of chronic kidney disease (end-stage renal disease) are continuously increasing, particularly in elderly patients. Poor adherence to complex multimodal therapies is a widely recognized problem in the daily care of dialysis patients, contributing to excess morbidity and mortality of this population. Aims and objectives was to assess the adherence to medications among patients undergoing haemodialysis and to explore the factors affecting non adherence.Methods: After obtaining approval from Institutional Ethics Committee, a prospective observational study was carried out among 150 patients, who were on dialysis in a tertiary care hospital, Hassan. An eight item Morisky Medication adherence questionnaire was used to assess medication adherence. Chi-square test applied to assess statistics.Results: Adherence levels were 28%, 42% and 30% for high, medium and poor adherence respectively. The overall prevalence of non-adherence among respondents was 30%. Among them 77.77% were males, 44.44% belonged to age group of 41-60 years, 40% illiterate, 60% employed, 51.11% of patients with smoking and alcoholic habits were not adherent to Dialysis. Other reasons contributing to non-adherence to treatment were forget fullness (86.66%), inadequate knowledge about side effects (80%), unhappy clinical visits (71.11%) and lack of assistance (48.88%).Conclusions: In this study patient showed moderate adherence. This emphasizes the need for constant motivation and education at frequent intervals to ensure better adherence.
Knowledge, attitude and practices of generic names usage in prescription among the medical postgraduate residents of a tertiary care teaching hospital: an observational cross-sectional study
Authors: Jadhav Rakesh R. , Kulkarni Rushikesh S. , Rathod Arati V.
Published: April 2019

Background: Establishment of Pradhan Mantri Bhartiya Janaushadhi Kendras through Pradhan Mantri Janaushadhi Pariyojana (PMBJP) is a breakthrough step to reduce expenses in healthcare due to costly branded names in prescription. Medical council of India also amended clause 1.5 of the Indian Medical Council Regulations, 2002 mandating the doctors to prescribe medicines by generic names in place of brand names. Moreover, medical practitioner nowadays has raised concern about education/qualification of the chemist who is being made the decision maker.Methods: In this questionnaire based cross-sectional observational study, all students admitted to post graduation course in academic year 2018 were included and those who were not willing to give consent were excluded from study. A knowledge, attitude and practices (KAP) questionnaire containing 12 questions was assessed by using true/false type and Likert scale-based questions. Descriptive statistics used to generate frequencies, percentages and proportions.Results: Majority of the population have answered positively about knowledge questions. Surprisingly 72.41% population don’t know about process of new drug approval. Most of them agreed to pros and cons of generic drug prescribing. 58.14% population always write generic names in their prescription. Shockingly 74.42% population write prescription based on their knowledge from promotional literature by a medical representative.Conclusions: Findings of present study highlights usefulness of the practice of writing generic names in prescriptions. It also raises concern about professional qualification of the chemist who will be decision maker in drug delivery to consumers.
Effectiveness of malabaricone-A in P-glycoprotein over-expressing cancer cell lines
Authors: Yasmin Nafisha , Manna Alak , Sarkar Sritama D. , Bandyopadhyay Chandrakana , Bauri Ajay K. , Chattopadhyay Subrata , Chatterjee Mitali
Published: April 2019

Background: A major impediment in treatment for cancers is resistance to chemotherapy and is primarily attributed to over-expression of efflux pumps. This study aimed to establish the cytotoxicity of malabaricone-A (MAL-A) in P-glycoprotein/multidrug resistance (P-gp/MDR) over-expressing hematopoietic cancer cell lines.Methods: Leukemia and multiple myeloma cell lines were indirectly evaluated for their P-gp/MDR status by examining Calcein-AM fluorescence and cell viability was assessed by the MTS-PMS assay.Results: The fluorescence of calcein was significantly decreased in three cell lines LP-1, RPMI-8226 and CEM-ADR 5000 and reversal with verapamil endorsed their P-gp/MDR activity. The mean IC50 of MAL-A in these MDR+ cell lines (5.40±1.41 to 12.33±0.78 µg/ml) was comparable with the MDR- leukemic (9.72±1.08 to 19.26±0.75 µg/ml) and multiple myeloma cell lines (9.65±0.39 to 18.05±0.17 μg/ml).Conclusions: Irrespective of their P-gp activity, the cytotoxicity of MAL-A was comparable, making it worthy of future pharmacological consideration in multidrug resistance.
Assessment of the knowledge, attitude and practice of self medication among second year undergraduate medical students in a tertiary care teaching hospital
Authors: Gupta Seema , Khajuria Kanika , Bhat Nusrat K. , Khajuria Vijay , Mehra Akanksha
Published: April 2019

Background: Inappropriate self-medication is a cause of concern as it can result in wasteful expenditure, prolonged suffering, drug dependence, resistance and increase in morbidity. Self medication assumes significance among medical students as they have knowledge about ailments and medicines. The aim of the study was to assess the knowledge, attitude and practice of self-medication among undergraduate medical students.Methods: The present study was conducted in December 2017 among second professional undergraduate medical students in the Department of Pharmacology and Therapeutics, GMC Jammu after obtaining approval from the Institutional Ethics Committee of GMC, Jammu. A total of 123 students who took self-medication during last six months were included and given a questionnaire that included open and close ended questions about self-medication. Data was analysed using Microsoft Excel and presented as number and percentages.Results: Total of 123 second professional undergraduate MBBS students were analysed. 72 (58.53%) were males and 51 (41.46%) were females. 96 (78%) students practised self-medication. Allopathic drugs were most commonly used for self medication (93.5%), followed by Ayurvedic drugs. Fever and headache were common ailments treated with self medication. Common class of drugs used for self medication were antipyretics (66.6%), antibiotics (42.2%). Adverse drug reactions were perceived as the most common disadvantage of self medication. Analysis of source of information revealed that old prescriptions (33%), internet (18%) were the main sources of information. Regarding prevention of self medication, many students perceived that enhancing awareness was the most effective solution (72.3%) followed by stoppage of supply of medicines without prescription(39.8%).Conclusions: Self medication is practised by a majority of students. As responsible self medication is now increasingly being considered as a component of self-care, there is need for review of educational programs especially teaching of rational and judicious use of medicines to the undergraduate medical students.
Analysis of drug promotional literatures in a tertiary care hospital: a cross sectional study
Authors: Vyas Noopur , Shahani Savita
Published: April 2019

Background: Large numbers of new drugs are introduced into the market every day and pharmaceutical companies are in the business of development and selling of new drug. There are different modes of drug promotion which include visual aids, leave behind leaflets and audio visuals. Drug Promotional Literatures (DPL’s) claim to provide vital and accurate information regarding the drug. To ensure rational use of drugs a set of standards laid by the WHO for ethical drug promotion.Methods: A cross sectional observational study was performed in Department of Pharmacology at a tertiary care teaching hospital of Navi Mumbai. A total of 100 drug promotional literatures were randomly collected from different outpatient departments and were evaluated by using WHO guidelines.Results: None of drug promotional literature fulfilled all WHO criteria. Generic name, Brand name, active ingredients were mentioned in all. The problem causing ingredient was not mentioned in any of the cases. Safety information was not complete, adverse drug reactions were mentioned in only 45% of the cases, contraindications and drug interactions were mentioned in 39% of the cases. Manufacturer details including name and address of manufacturer was mentioned in 67% of the DPL’s. References were mentioned in 80% of the literature out of which 84% were from journal articles.Conclusions: None of the DPL’s satisfied all the WHO criteria. Incomplete information may lead to irrational prescription of drugs. Therefore, more strict regulations need to be implemented and physicians must critically evaluate DPL’s before considering the same for prescribing.
Comparison of Beers criteria and EU(7) potentially inappropriate medications list for the potentially inappropriate medications in Indian elderly inpatients
Authors: Thummar Manoj H. , Patel Tejas K. , Godbole Varsha Y. , Saurabh Manoj Kumar
Published: April 2019

Background: Use of inappropriate medication is an important problem in present geriatric clinical practice. No specific potentially inappropriate medications (PIM) tools are available considering the availability of drugs in India. Aim and objective were to assess prevalence and pattern of potentially inappropriate medication (PIM) use in elderly inpatients by updated Beers criteria 2015 and EU(7) PIM list 2015.Methods: This cross-sectional study was carried out on medical records of elderly patients (≥65 yrs) admitted in the internal medicine wards and intensive care units (ICU) over a period of 6 weeks. The medications were evaluated for the PIM use as per Beers criteria and EU(7) PIM list.Results: A total of 225 patients (mean age- 71.48 yrs) were admitted in internal medicine wards and ICU during study period. Total 184 PIM belonged to 33 different medications were used during study period. The prevalence of PIM in internal medicine wards and ICUs were 51.96% and 57.14%, respectively. The prevalence of PIM was significantly higher with the EU(7) PIM list than Beers criteria (49.77% vs. 21.77%) [p<0.0001]. The commonly prescribed PIM were dextromethorphan (13.33%), ranitidine (11.11%) and glipizide (10.22%).Conclusions: Elderly patients frequently receive PIM. EU(7) PIM list identifies more PIM among elderly inpatients than Beers criteria.
A Study of Association of Diabetes Mellitus and Vitiligo Patients
Authors: Korde Sayli Shekhar , Gugle Anil Shankarlal , Pawar Manoj Karbhari
Published: April 2019

The most accepted pathogenesis of vitiligo is autoimmune theory and as a result vitiligo is known to be associated with many autoimmune diseases one of which is diabetes mellitus. A comparative cross-sectional study was done in Department of Dermatology in a tertiary care institute. Eighty patients of vitiligo and eighty controls in the age group of 12-60 years were investigated for fasting blood glucose levels. Five (6.25%) out of eighty patients with vitiligo were found to have diabetes mellitus. This study indicates that all the patients of vitiligo must be screened for diabetes mellitus, for its early diagnosis, to avoid its adverse impact on health status.
Study of Serum Alkaline Phosphatase Levels among Psoriasis Patients and Comparative Group in Tertiary Care Institute
Authors: Deshmukh Milind D. , Agiwal Paresh Shirish , Gugle Anil S. , Kumavat Shrikant , Pawar Manoj
Published: April 2019

Background: Psoriasis is a chronic relapsing autoimmune skin disease of unknown etiology, characterised by complex alterations in epidermal growth and differentiation. Oxidative stress is a known risk factor for exacerbation of psoriasis. Serum alkaline phosphatase level is a marker of oxidative stress in body. Aims and Objectives: To study and compare serum alkaline phosphatase levels in cases of psoriasis. Materials and Methods: Serum Alkaline Phosphatase levels were evaluated in 100 cases of psoriasis and controls. Results: There was no statistically significant difference between serum alkaline phosphatase levels among cases and controls. Conclusion: Serum alkaline phosphatase levels, as a marker of oxidative stress is not significantly raised in cases of psoriasis.
Prospective Study of Psychiatric Morbidity and Evaluation of Quality of Life in Patients Undergoing Hysterectomy
Authors: Gupte S. G. , Nagabhirava Gautami
Published: April 2019

Background: Hysterectomy is the most common gynecological operation in the world, secondary to caesarian section. However, women undergoing hysterectomy face a multitude of psychosocial problems both before and after hysterectomy. Aims: To study and compare psychiatric morbidity, quality of life in patients on admission and after about 6 weeks post hysterectomy. Methods and Methodology: A total number of 100 women undergoing hysterectomy were included after they satisfied the eligibility criteria. Written informed consent was taken from all the study participants. After being evaluated by the inpatient Department of Obstetrics and Gynecology, such cases along with records of hospitalization and treatment were evaluated for any psychiatric morbidity and quality of life was assessed. Instruments used for assessment include WHOQOL-BREF, M.I.N.I, and Semi structured proforma. Results: There was overall improvement in psychiatric morbidity (30% to 12%). There was improvement in all domains of quality of life (p<0.0001). Conclusion: Most patients undergo hysterectomy to relieve symptoms and to improve their quality of life. Further research should be done to assess long term impact of hysterectomy.
Clinical Profile of Respiratory Distress in Newborn
Authors: Sonawane Ravindra , Patil Akshay , Sonawane Sagar
Published: April 2019

Introduction: Pulmonary disorders represent one of the most common diagnoses in infants admitted to neonatal units. The clinical presentation of respiratory distress in the new born includes apnea, cyanosis, grunting, inspiratory stridor, nasal flaring, poor feeding, and tachypnea. Most cases are caused by transient tachypnea of the newborn, respiratory distress syndrome, or meconium aspiration syndrome, but various other causes are possible. Objectives: Study was performed to analyze clinical profile, risk factors and outcome in terms of mortality. Methods: Data was collected for 78 newborns included in the study with respiratory distress. General information, socioeconomic status, history and clinical examination were documented. Newborn with respiratory distress were shifted to NICU for further management. Time of onset of distress was documented and the severity of the distress was documented and the severity was assessed by using Silverman and Anderson clinical scoring. Duration of O2 therapy, intervention done in the form of surgical/ventilator/surfactant therapy/treatment and mortality was documented to assess the clinical outcome against the final diagnosis. Results: It was seen that in 97.4% of the cases of newborn respiratory distress the cause was respiratory in origin. Majority of the newborns had severe respiratory distress (47.43%) and moderate respiratory distress (46.15%) compared to mild distress (6.4%). 100% of newborns with RDS was diagnosed with severe respiratory distress (5 out of 5) and 73.9% was with diagnosis of MAS (17 out of 23) had developed severe respiratory distress as compared to 29.8% of the neonates with respiratory distress with diagnosis of TTNB (14 out of 47). 55.5% of the newborns (30 out of 54) male babies developed severe respiratory distress compared to 33.3% (8 out of 24) female babies. Interpretation and Conclusions: Transient tachypnea of the newborn is the most common cause of respiratory distress in newborn. Almost 50% of newborn with respiratory distress develop severe respiratory distress which require intensive monitoring. Risk factors like high maternal age, primigravida mothers, Small for gestation age, birth weight less than 2.5Kg associated with severe respiratory distress in newborns.
To Study the Correlation between Maternal Body Mass Index and Birth Weight of the Baby
Authors: Patole Kiran P. , Paprikar Deepti Satish
Published: April 2019

Maternal BMI directly or indirectly indicates maternal health and wellbeing. Birth weight of the baby is an important determinant of the neonate's wellbeing. A total of 150 women who had delivered at a tertiary care hospital fulfilling the inclusion criteria were studied. They were classified into underweight, average weight, overweight according to the BMI noted in the first trimester. 22 women (14.7%) were underweight having BMI less than 18.5 kg/m2. 97 women (64.7%) belonged to the average weight group with BMI between 18.5 kg/m2 to 25 kg/m2. 31 women (20.7%) belonged to the overweight group with BMI more than 25 kg/m2. In the underweight group, 13 (59.1%) had underweight babies, 9 (40.9%) had appropriate for gestational age babies and there were no large for gestational age babies. In the average weight group, 22 (22.7%) had underweight babies, 72 (74.2%) had appropriate for gestational age babies and 3 (3.1%) had large for gestational age babies. In the overweight group, 6 (19.4%) had underweight babies, 17 (54.8%) had appropriate for gestational age babies while 8 (25.8%) had large for gestational age babies. Correlation of maternal BMI and birth weight of the babies was found to be statistically significant. Underweight mothers had significantly more chance of having a small for gestational age baby as compared to the average weight mothers. Overweight mothers have significantly more chance of having a large for gestational age baby as compared to average weight mothers.
Maternal and Perinatal Outcome in Patients with HELLP Syndrome
Authors: Kamble Rohit Chandrakant , Gupte Nilima S.
Published: April 2019

HELLP syndrome (haemolysis, elevated liver enzymes, and low platelets) is a component of hypertensive disorders of pregnancy which is associated with significant maternal as well as perinatal morbidity and mortality. Maternal mortality is due to consequences such as pulmonary oedema, renal failure, disseminated intravascular coagulation and subcapsular liver hematoma. Perinatal mortality appears to be primarily related to the gestational age at the time of delivery. This study evaluates the maternal and perinatal outcome in HELLP syndrome so that the management is improved resulting in reduced mortality and morbidity. Objectives: A. To study maternal outcome in patients diagnosed with HELLP syndrome. B. To study perinatal outcome in patients with HELLP syndrome. Methods: This study was conducted in department of obstetrics and gynaecology of medical college and tertiary health care centre. A consecutive series of 56 pregnant women above 24 weeks of gestational age with HELLP syndrome were admitted at a tertiary care hospital, during the period of 24 months from 30th November, 2015 to 31st October, 2017. History, clinical data, detailed laboratory investigations were studied and categorized by Mississippi classification for better analysis of complication and outcome in HELLP syndrome. Results: Total 56 cases of HELLP syndrome were studied. Majority of the patients were primigravidae belonging to lower socio-economic status, which were unbooked with no proper antenatal care. 60.71% of the patients had maternal complications. The complications were severe anemia in 21.43%, renal complication in 21.43%, DIC in 19.64%, abruption 14.29%, respiratory complication 7.15%, ascites 3.57% and septicemia in 3.57% and maternal mortality rate was 14.28%. A high incidence of perinatal morbidity and mortality (46.43%) was seen. Major contributing factors being prematurity, fetal growth restriction and birth asphyxia. Conclusion: HELLP syndrome is associated with increased maternal and perinatal morbidity and mortality. Once diagnosis is made, it warrants aggressive intervention with control of blood pressure, antiseizure prophylaxis and corticosteroid treatment and delivery. We have to increase grass root level antenatal care. Early detection and prompt management of pre-eclampsia is the most important approach to the prevention of HELLP syndrome.
Maternal Exercise Uncovers Placental Insufficiency in Diabetic Mothers
Authors: BM Petrikovsky , EV Zharov , D Plotkin , E Petrikovsky
Published: April 2019

Regular physical activity during pregnancy improves or maintains physical fitness, helps with weight management, reduces the risk of gestational diabetes, and enhances patient’s psychological well-being. We studied the possibility to use maternal exercise to test placental reserves in diabetic mothers. We used a motorized treadmill in a moderate exercise regimen (15-minute fast walk at a speed of 3 mph with an incline of 15-25 degrees). Fetal monitoring was provided by using standard Phillips equipment (Avalon CTS and FM40). Adverse fetal outcomes were considered if one or more of the following were present: Category III Fetal Heart Rate (FHR) tracing, 5-minute Apgar score of less than 7, admission to the neonatal intensive care nursery, fetal growth restriction, and fetal and early neonatal death. A total of 819 fetal assessments were performed: 160 patients had gestational diabetes, 80 had pregestational diabetes. The most common complication in fetuses with positive prenatal test results was abnormal FHR in labor (36%) followed by low Apgar score (21%) and need for NICU admission (19%). Most of the adverse outcomes had good correlation with positive results of the exercise test. In conclusion, it appears that maternal exercise causes changes in FHR, which may be used to assess placental and fetal reserves.
Comparativo entre Efeito da Carbonatação em Corpos-de-Prova de Concreto Expostos na Cidade de Pelotas/RS e o Uso de Modelos Matemáticos
Authors: Ferreira Carina Farias , Paliga Charlei Marcelo , Torres Ariela Da Silva
Published: April 2019

A carbonatação é uma das principais causas do comprometimento do desempenho de estruturas de concreto ao longo do tempo, sendo estudada por diferentes métodos. Esta pesquisa teve como objetivo fazer uma análise comparativa entre a previsão feita por modelos matemáticos existentes na literatura com a profundidade carbonatada encontrada em elementos de concreto na cidade de Pelotas/RS. Para tanto, foram expostos corpos-de-prova de concreto (10x20cm) em diferentes bairros da cidade com o intuito de verificar se ocorre diferença na profundidade de penetração de CO2 ao longo do período de exposição. Os corpos-de-prova foram expostos por um período total de 16 meses, sendo retiradas amostras a cada 4 meses para aplicação de fenolftaleína e determinação da profundidade carbonatada. Em seguida, para comparação e análise dos resultados, foram aplicados os modelos de Smolczyk, Vesikari, Morinaga, Helene e Possan. Como resultado, foram encontrados valores significativos de CO2, e através da aplicação dos modelos de previsão, foi possível observar que o modelo de Helene, apesar das diferenças entre os valores obtidos com sua aplicação e os dados do ensaio natural, representou de forma satisfatória a penetração de CO2 ao longo do tempo para a cidade de Pelotas/RS, muito possivelmente devido às características do concreto utilizado.
Avaliação de desempenho térmico nos Módulos Antárticos Emergenciais (Brasil)
Authors: Martins Wagner Gomes , Alvarez Cristina Engel de
Published: April 2019

Os Módulos Antárticos Emergenciais – MAE, instalados na Península Keller, desde 2013 têm servido à continuidade das atividades desenvolvidas no local após o incêndio de parte da brasileira Estação Antártica Comandante Ferraz. Tendo-se em vista as condições climáticas extremas e a necessidade de se obter conforto térmico com o menor gasto energético e impacto ao meio-ambiente, avaliou-se o desempenho do conjunto edificado, particularmente quanto à sua capacidade de manter a temperatura interna estável e dentro de uma faixa de aceitação conforme as normas aplicáveis, considerando-se também o isolamento proporcionado pela envoltória. Através de medições de temperatura, com o tratamento dos dados coletados e a análise dos resultados, verificou-se que não houve correlação entre a temperatura externa e a interna, sendo possível inferir que a envoltória garante o isolamento do ambiente interno, apesar de identificados alguns problemas de estanqueidade, e/ou que o sistema de aquecimento é capaz de compensar as diferenças de temperatura. É possível que os resfriamentos observados e as diferenças de temperatura entre horas seguidas tenham sido provocados pelo comportamento em uso, com perda de calor pela abertura de portas, por exemplo, principalmente no período de verão, em que há uma maior quantidade e movimentação de usuários.
Comparison of Middle-Sized PTC and PV Power Plants for METU NCC
Authors: Taylan Gozde , Taylan Onur , Fahrioglu Murat
Published: April 2019

Since usage of fossil fuels for producing electricity causes climate change, renewable energy options have become one of the best substitution for fossil fuels. Solar energy promises high amount of resources for producing electricity. Among solar energy alternatives, Photovoltaic (PV) and Parabolic Trough Collectors (PTC) are dominant in the market. This paper compares middle size of PV and PTC power plant for the electricity need of Middle East Technical University Northern Cyprus Campus. Based on the maximum hourly demand of METU NCC, both PV and PTC are sized to 3 MWe. The simulations were performed via SAM software using the hourly values from typical meteorological data, which include solar irradiation, wind speed, dry and wet bulb temperatures, relative humidity and pressure. For the PTC and PV plants, commercially available components are used. The scenario assumes METU NCC to be a grid-connected micro-grid with one-way tariff, so that any deficit energy can be met by the utility and any excess energy produced by the suggested renewable energy systems will be given to the grid for free. The results indicate that 3 MW PV plant would generate annual energy of about 4.95 GWh with a capacity factor of 18.9%. These numbers would yield to a LCOE value of 2.60 Â¢/kWh. On the other hand, the suggested 3 MW PTC plant with 2 solar multiple would supply about annual energy of 6.3 GWh at a capacity factor of 24.0%. The LCOE of the energy from PTC plant was estimated to be 8.47 Â¢/kWh due to high capital and operation cost of PTC plants compared to PV plants. However, over years the cost of PTC power plants has been decreasing. Additionally, both PTC plant and PV plant would consume water only for cleaning purposes that makes them suitable for Cyprus water scarcity conditions. Overall, this study shows pros and cons of middle-sized PV and PTC plants with the case study of METU NCC.

 

Keywords: economic comparison, levelized cost of energy, parabolic trough, photovoltaic, renewable energy, solar energy
Proceso de exclusión simple simétrico y la ecuación de calor
Authors: Gonçalves Patricia , Jiménez Oviedo Byron
Published: April 2019

Nuestro principal foco consiste en motivar al lector para el estudio de los sistemas de partículas y que el lector entienda, de forma más o menos heurística e intuitiva, la deducción de ecuaciones diferenciales parciales a través de sistemas microscópicos subyacentes con dinámicas probabilistas. Para esto vamos a utilizar el modelo llamado proceso de exclusión simple simétrico que está en contacto con depósitos de partículas. Y la ecuación diferencial parcial involucrada es la  ecuación de calor con condiciones de Dirichlet.
Choosing Treatment for Dogs With Generalised Demodicosis – Isoxazolines or Imidacloprid and Moxidectin?
Authors: Long Sarah
Published: April 2019

PICO question

In dogs with generalised demodicosis, are isoxazolines as effective as a combined formulation of imidacloprid and moxidectin at reducing mite count and the severity of associated clinical signs?

Clinical bottom line

Five single-blinded, randomised, positive control trials, most under laboratory conditions, directly compared the use of isoxazolines against moxidectin/imidacloprid to treat canine generalised demodicosis. All of them showed comparable efficacy of isoxazolines. Three different isoxazolines were studied with two routes of administration (oral and topical) and four different dosing frequencies of moxidectin/imidacloprid. This made the papers more challenging to compare however, the evidence provided is sufficient to support their use. All of these trials were sponsored by the manufacturers of their respective isoxazoline products which may bias the study design and reporting of results. It is worth noting that sarolaner (Simparica™, Zoetis UK) was licensed in the UK for the treatment of canine demodicosis in January 2018 and that in the UK the Cascade should be followed when prescribing treatments. The licensed use of isoxazolines in other countries is beyond the scope of this article and the reader is urged to check local regulatory body advice before prescribing the below medications.

  
Mitigasi Kecelakaan Kapal di Pelawangan Pantai Pancer Kecamatan Puger Kabupaten Jember
Authors: Kadhafi Muammar
Published: April 2019

Profesi nelayan merupakan profesi yang sangat beresiko karena melakukan aktifitas dilaut yang kondisinya sangat dinamis, ditambah kondisi gelombang laut pantai selatan yang cukup tinggi. Salah satu kecelakaan kapal nelayan di Pantai Puger Jember terjadi pada Juli 2018 yang menyebabkan 9 orang nelayan meninggal dunia. Disisi lain, mayoritas nelayan merupakan kepala keluarga yang harus menafkahi anak, istri dan keluarganya. Ketika kepala keluarga meninggal dunia, maka akan menyebabkan terjadinya masalah-masalah lain sebagai persoalan turunannya seperti kemiskinan dan lain sebagainya. Penyadaran akan pentingnya aspek keselamat kerja dilakukan dalam bentuk kegiatan sosialisasi kepada masyarakat nelayan meliputi presentasi dan diskusi, pembagian alat keselamatan berupa pelampung dan simulasi secara langsung dilapangan guna mengetahui apakah para nelayan menerapkan pengetahuan yang diberikan dengan baik.

Kata Kunci: Puger, kecelakaan kapal, keselamatan, nelayan.

A fishermen's profession is very risky because they perform activities in the sea, which can be dynamic; additionally, the south coast sea waves can be quite high. A fishing boat accident on Puger Jember Beach occurred in July 2018, and left nine fishermen dead. The majority of fishermen are family heads who have to provide for their children, wives, and families. When the head of the family dies, it will cause other derivative problems such as poverty. Awareness of the importance of work safety aspects is carried out in the form of socialization activities within fishing communities. These activities include presentations and discussions, the distribution of safety equipment in the form of buoys, and simulations directly in the field to find out whether the fishermen properly apply the knowledge provided.

Keywords: Puger, boat accident, safety, fisherman.
Pemberdayaan Lansia Produktif, Aktif, Sehat Melalui Promosi Kesehatan dan Pemanfaatan Tanaman Obat di Desa Bumiharjo Kecamatan Glenmore Kabupaten Banyuwangi
Authors: Andriani Yeni , Raraningrum Vita , Sulistyowati Reni
Published: April 2019

Desa Bumiharjo merupakan salah satu desa yang terletak di Kecamatan Glenmore Kabupaten Banyuwangi yang membawahi 3 dusun yaitu Dusun Wonoasih, Dusun Sugih Waras dan Dusun Balerejo. Penduduk Desa Bumiharjo sebagian besar merupakan lansia. Lansia di Desa Bumiharjo mayoritas berpendidikan rendah, yaitu hanya lulusan SD, sehingga sebagian besar bekerja sebagai buruh tani dan rata-rata penghasilannya sangat jauh dibawah Upah Minimum Regional (UMR) Kabupaten Banyuwangi. Program kemitraan masyarakat (PKM) ini bertujuan untuk memberikan penguatan pada program posyandu lansia di Desa Bumiharjo, dengan memberikan pendidikan kesehatan, mengajari senam lansia dan membudidayakan serta memanfaatkan tanaman obat keluarga. Kegiatan ini dilaksanakan dalam bentuk promosi kesehatan melalui pemberian pendidikan kesehatan penyakit tidak menular yang sering dialami oleh lansia serta cara pencegahan dan penanggulangannya dengan memanfaatkan tanaman obat keluarga. Metode yang digunakan adalah ceramah disertai tanya jawab dengan media leaflet. Hasil program ini yaitu pelaksanaan kegiatan PKM secara garis besar sudah cukup baik (80%). Promosi kesehatan berupa pemberian pendidikan kesehatan efektif digunakan untuk meningkatkan pengetahuan lansia, senam lansia untuk meningkatkan keaktifan fisik dan pemanfaatan tanaman obat keluarga untuk menjaga kesehatan lansia dengan bahan-bahan yang alami serta dalam jangka panjang mampu meningkatkan derajat kesehatan dan usia harapan hidup lansia.

Kata Kunci: Lansia, Pemberdayaan, Tanaman Obat

 Bumiharjo Village is one of the villages located in Glenmore Sub-district, Banyuwangi Regency which is in charge of 3 hamlets, namely, Wonoasih Hamlet, Sugih Waras Hamlet, and Balerejo Hamlet. Most of the residents of Bumiharjo Village are elderly. Elderly people in the village of Bumiharjo has a low level of education, which is only collecting elementary school, more work as farm laborers and the average is higher than the Regional Minimum Wage (UMR) of Banyuwangi Regency. This community partnership program (PKM) supports the elderly posyandu program in Bumiharjo Village, provides health education, teaches elderly gymnastics and cultivates and utilizes family medicinal plants. This activity is carried out in the form of health promotion through the implementation of non-communicable health education that is often attended by the elderly as well as ways to prevent and utilize family medicinal plants. The method used is question and answer with media leaflets. The result of this program is that the activities carried out by PKM in general have been quite good (80%). Health promotion consisting of effective health education is used to increase the knowledge of the elderly, elderly gymnastics to improve physical activity and the use of medicinal plants to improve the health of the elderly with natural ingredients and in improving health and the elderly.

Keywords: Elderly, Empowerment, Medicinal Plants
Antartica's Sovereignty: Adoption of Artic Council Concept as a Better Replacement for Antartica Treaty System (ATS)
Authors: Ladiqi Suyatno , Hamzah Akmal
Published: April 2019

The conflict surrounding the sovereignty over the region of Antarctica is a long-standing issue that has plagued the claimant states for decades. The exhaustion of mineral and raw material fuels the hostility and struggle for dominance over the unclaimed region which beliefs to be the largest remaining reserve of oil and gas as well as other valuable natural resources. With growing number of claimant states and the inexistence of proper international framework, the issue over Antarctica is a time-ticking bomb waiting to burst and causes a major friction over the South Pole. Due to the success achieved by Arctic Council in managing the Arctic region inspire this paper to propose and evaluate the idea of establishing an “Antarctica Council” as a crucial recourse to solve what Antarctica Treaty System (ATS) has failed to achieve. This paper is an examination of analysis and critiques in legal documents and international reports that seek a critical approach over the ineffectiveness of the existing legal framework and possible improvement in Arctic council concept adoptions.
Smart Maritime Diplomacy: Diplomasi Maritim Indonesia Menuju Poros Maritim Dunia
Authors: Rijal Najamuddin Khairur
Published: April 2019

This article examines the efforts of Indonesia's maritime diplomacy, especially in Southeast Asia and ASEAN to realize the World Maritime Axis (WMA) vision. WMA is the “jargon” of the Joko Widodo government to realize Indonesia’s ideals as an advanced, independent, and strong maritime state, and has positive contribution to the world. Through a descriptive-qualitative research approach, to answer the efforts of Indonesian maritime diplomacy, the primary data was collected through a review of the annual reports of the Ministry of Foreign Affairs and the Ministry of Maritime Affairs and Fisheries. The secondary data is obtained through various literature related to WMA and Indonesian maritime diplomacy in Southeast Asia and ASEAN. By using Christian Le Miere's conceptualization of maritime diplomacy, this article shows that Indonesia’s maritime diplomacy efforts integrate the soft approach through cooperation and persuasive efforts with a hard approach through coercive action. By the author, this efforts is referred as Smart Maritime Diplomacy.
Simultaneidade espacial multicêntrica na música de Stravinsky: questões teóricas e novos exemplos
Authors: Viegas Alexy
Published: April 2019

Conforme Straus (2014), certos procedimentos composicionais de Stravinsky podem ser entendidos por meio da elaboração de duas camadas simultâneas de prolongamento de quintas justas separadas por algum intervalo. Lerdahl (2001) sugere um tipo de hierarquia tonal que pode ser modelada por um espaço multidimensional, no qual determinada distância espacial equivalerá à distância cognitiva. Acolhendo conceitos de Lerdahl (2001) e Straus (2014), este trabalho busca investigar aspectos qualitativos da simultaneidade multiespacial na música de Stravinsky, atentando-se especialmente a passagens de Ragtime for Eleven Instruments (1918), Preludium for Jazz Ensemble (1937), Tango (1940) e Ebony Concerto (1945), obras orientadas pela influência da música popular americana. Este artigo se detém aos desdobramentos da questão da simultaneidade em processos composicionais de Stravinsky, sobretudo mediante aquilo que denominamos como “prolongamentos simultâneos multicêntricos”. Este artigo busca ampliar tal discussão pelo intermédio de uma perspectiva teórica baseada principalmente na ideia de prolongamento estrutural provida pela teoria neoschenkeriana.
POTENSI PAJAK BUMI DAN BANGUNAN PERKOTAAN PEDESAAN (PBB-P2) KOTA BANJARMASIN
Authors: Muzdalifah Muzdalifah
Published: April 2019

Abstrak- Tujuan penelitian ini adalah untuk mengetahui besarnya potensi penerimaan Pajak Bumi dan Bangunan (PBB) di Kota Banjarmasin tahun 2018. Jenis penelitian yang digunakan dalam penelitian ini adalah kuantitatif. Manfaat penelitian ini adalah sebagai bahan informasi kepada Pemerintah Daerah Kota Banjarmasin dalam pengambilan kebijakan serta pengelolaan Pajak Bumi dan Bangunan (PBB) pada tahun 2018. Penelitian ini memberikan gambaran bahwa potensi penerimaan Pajak Bumi dan Bangunan (PBB) di Kota Banjarmasin cukup besar karena besarnya piutang yang tidak tertagih sehingga jika diasumsikam besarnya peningkatan penerimaan PBB sebesar rata-rata pertumbuhan ditambah dengan potensi besarnya piutang tertagih sama dengan besarnya pertumbuhan ekonomi Kota sebesar 6,28% maka besarnya potensi penerimaan BPP P2 Kota Banjarmasin Tahun 2018 adalah sebesar Rp. 28.550.753.211,- mengalami peningkatan dari tahun 2017 yang hanya sebesar Rp. 24.910.454.029,- Peningkatan ini bisa tercapai jika kendala dilapangan dapat di atas yakni berupa pembersihan data melalui pemutahiran data yang selama ini digunakan oleh Bakueda yang merupakan data dari KPP Pratama yang masih banyak tumpang tindih, selain itu juga perlu dilakukan treatment berupa discount terhadap piutang pajak serta pemutihan terhadap pajak yang datanya tumpang tindih. Kata Kunci : Potensi, Penerimaan, PBB-P2, Kota Banjarmasin
Potensi Dan Strategi Pengembangan Industri Kerajinan Anyaman Di Kabupaten Tapin
Authors: Dewi Rahayu , Muzdalifah Muzdalifah , Nuryadin Muhammad Rusmin , Rakhmatullah Akhsanul
Published: April 2019

Abstrak – Penelitian ini bertujuan untuk mengetahui potensi dan strategi pengembangan industri kerajinan anyaman di Kabupaten Tapin. Penelitian bersifat kualitatif dengan data yang diperoleh dari observasi di lapangan dan wawancara kepada pihak yang terlibat yaitu BAPPEDA, Dinas Perindustrian, Perdagangan, dan Koperasi Kabupaten Tapin dan para pengrajin anyaman. Teknik analisa yang digunakan adalah analisis deskriptif dan analisis SWOT. Hasil penelitian menunjukkan bahwa Industri kerajinan anyaman di Kabupaten Tapin mempunyai potensi yang cukup besar untuk terus dikembangkan dengan pembinaan secara intensif dan berkelanjutan. Peranan peningkatan SDM, pemanfaatan teknologi, akses keuangan dan permodalan, akses pemasaran, akses informasi, dan manajemen sangat penting dalam mengembangkan industri kerajinan anyaman di Kabupaten Tapin. Peranan pemerintah daerah melalui Dinas Perindustrian, Perdagangan, Koperasi, dan UKM dan Dewan Kerajinan Nasional Daerah (DEKRANASDA) dalam memberikan bimbingan/pelatihan serta menyelenggarakan pameran/expo dan fasilitasi lainnya terbukti mampu mendorong upaya meningkatkan daya saing industri kerajinan anyaman secara signifikan, hanya saja intensitasnya masih kurang.
Kata Kunci: Industri Kecil, Kerajinan Anyaman, Analisis SWOT, Kabupaten Tapin
ANALISIS POTENSI PENGEMBANGAN EKONOMI MIKRO DI KABUPATEN HULU SUNGAI TENGAH
Authors: Yunani Ahmad
Published: April 2019

Abstrak-Tujuan Penelitian ini adalah untuk Kajian Perekonomian Daerah Kabupaten Hulu Sungai Tengah sehingga penelitian ini dapat digunakan sebagai evaluasi dan perencanaan dalam upaya mendukung program pembangunan daerah dan dalam rangka menganalisa perekonomian daerah dilihat dari sektor UMKM dan IKM yang dapat meningkatkan PAD, Kesempatan Kerja dan Kesejahteraan Masyarakat di Kabupaten Hulu Sungai Tengah. Hasil penelitian menunjukkan bahwa Kebijakan pengembangan ekonomi mikro di Kabupaten Hulu Sungai Tengah pada tahun 2017, dibagai menjadi empat kategori yaitu bantuan langsung, bantuan infrastruktur pendukung dan pengembangan kawasan, bantuan penguatan lembaga (capacity building), dan bantuan pemasaran (marketting). Masyarakat menilai bahwa tidak merasa puas dengan kinerja Instansi Pemerintah terkait program pengembangan ekonomi mikro, hal itu ditunjukkan dengan prosentase 81,3 %, yang merasa puas sebesar 10,5 %, tidak tahu 5,8 %, dan tidak menjawab 2,4 %. Untuk keterlibatan dalam penyusunan rencana kerja (Renja) oleh SKPD terkait bahwa pelaku usaha ekonomi mikro tidak pernah terlibat ditunjukkan dengan prosentase 68, 4 % dan yang pernah terlibat sebesar 22,9 %, masyarakat miskin juga tidak pernah terlibat sebesar 66,6 % dan pernah terlibat sebesar 10,3 %, dan untuk kaum perempuan yang pernah terlibat sebesar 20,8 %, tidak pernah terlibat 35,8 % dan tidak tahu sebesar 38,9 %. Sasaran program pengembangan ekonomi mikro yang dilakukan Pemerintah Daerah Kabupaten Hulu Sungai Tengah , dinilai masyarakat belum mencapai sasaran, dimana penilaian tersebut ditunjukkan dengan prosentase 44,7 % (tidak tepat sasaran), untuk penilaian tepat sasaran sebesar 33,4 %, tidak tahu 19,2 %, dan tidak menjawab sebesar 2,6 %.Kata Kunci: ekonomi mikro, potensi, daerah