bluuebunny/crossref_metadata_2025 huggingface dataset:
Teatro como metodologia formativa na graduação em enfermagem
Authors: Souza Noemy dos Reis , Da Silva Rudval Souza , Suto Cleuma Sueli Santos , Costa Laura Emmanuela Lima
Published: July 2023

OBJETIVO: Compreender as contribuições do Teatro no formato Simulação como ferramenta de aprendizagem para a formação da enfermeira, e sua influência na competência clínica MÉTODOS E MATERIAIS: Revisão integrativa de literatura realizada a partir de buscas nas bases de dados e BDENF usando as palavras-chave: “Ensino de enfermagem”, “Simulação” e “Teatro”, publicados nas línguas Portuguesa, Espanhola e Inglesa. RESULTADOS:  Foram encontrados 169 artigos, após seleção, 21 artigos integraram o corpus desta pesquisa. As estratégias que mais contribuem para a formação foram: Role Play, Paciente Simulado e Simulação Realística, o Brasil e o Chile lideram essa inciativa, sendo as IES brasileiras as que mais se destacam. O desenvolvimento do trabalho em equipe tanto contribuiu para as relações interpessoais durantes as práticas como se torna uma bagagem para as vivências profissionais futuras, além da redução da ansiedade no momento do cuidado ao paciente, e o desenvolvendo uma maior criticidade na identificação de medidas para a segurança do paciente. CONSIDERAÇÕES FINAIS: É possível considerar que o Teatro, do tipo Simulação, tem grande potencial metodológico e vem ganhando espaço como estratégia ativa de ensino sendo ressaltada por graduandos de enfermagem como uma estratégia e um importante meio para a formação da prática clínica.
La movilidad humana en los litigios climáticos: aportes de América latina desde la perspectiva de los derechos humanos
Authors: Capdeville Fernanda de Salles Cavedon , Andreola Serraglio Diogo , Velez-Echeverri Juliana , Madrigal-Pérez Mauricio Felipe , Castro-Buitrago Erika
Published: July 2023

Latin America is highly exposed to climate change, leading to human mobility patterns. Faced with the lack of specific legal instruments facilitating climate migrants’ protection, human rights-based climate litigation may add to their visibility, as well as address their protection needs. The study aims to investigate how far climate litigation cases in the region deal with the distinct dimensions of human mobility, as well as Latin America’s contribution in terms of human rights arguments. It identifies regional human rights arguments to cope with the current climate crisis that can be raised in litigation cases on the topic, such as the right to a safe climate, the extraterritoriality of human rights obligations and more recently the right not to be forcibly displaced. A categorization of climate litigation addressing the distinct dimensions of human mobility is presented. This categorization is divided according to the degree of consideration of the phenomenon, the type of litigation and the arguments invoked. The study then analyzes specific climate litigation cases associated with human mobility in Latin America and its central arguments. Advances in the consideration of human mobility in climate litigation were noted, as well as Latin America's potential to advance this trend, through new interpretative and argumentative developments and litigation strategies that contextualise human rights in the face of the climate crisis and favour the protection of climate migrants.
Jurisprudencia ambiental en Andalucía (Primer semestre 2023)
Authors: Mellado Ruiz Lorenzo
Published: July 2023

Jurisprudencia ambiental en Andalucía (Primer semestre 2023)
Los derechos de la naturaleza en Colombia, Ecuador y Bolivia: De la gramática constitucional y los procesos de reconocimiento, a una nueva interpretación
Authors: Vargas-Chaves Iván , Cumbe-Figueroa Alexandra
Published: July 2023

The objective of this paper is to analyze the liberal narrative on the recognition of the rights of nature in Colombia, Ecuador, and Bolivia, as well as study, from constitutional grammar and recognition processes, the interpretation of this phenomenon by Andean constitutionalism. The methodology chosen by the authors was the documentary analysis of the collected sources, such as laws, jurisprudence, and national and international legal doctrine, among others. As a result, the paper compiles some reflections on the scope of the rights of nature in these countries, from the constitutional grammar of the norms where this recognition was achieved. In addition, the authors propose a way of understanding the relationships in this process of legal recognition. All this occurred as a logical consequence of the constitutional interpretations of Andean constitutionalism, based on interculturality, plurinationality, and respect for biodiversity and cultural diversity.
Derecho y políticas ambientales en Andalucía (Primer semestre 2023)
Authors: Mora Ruiz Manuela
Published: July 2023

Derecho y políticas ambientales en Andalucía (Primer semestre 2023)
Derecho y políticas ambientales en el País Vasco (Primer semestre 2023)
Authors: Lazkano Brotóns Iñigo
Published: July 2023

Derecho y políticas ambientales en el País Vasco (Primer semestre 2023)
Derecho y políticas ambientales en Catalunya (Primer semestre 2023)
Authors: GIL CASION MARIA INES
Published: July 2023

Derecho y políticas ambientales en Catalunya (Primer semestre 2023)
Jurisprudencia constitucional ambiental (Primer semestre 2023)
Authors: Esteve-Jordà Clara
Published: July 2023

Jurisprudencia constitucional ambiental (Primer semestre 2023)
Derecho y políticas ambientales en Castilla y León (Primer semestre 2023)
Authors: Sanz Rubiales Iñigo
Published: July 2023

Derecho y políticas ambientales en Castilla y León (Primer semestre 2023)
Justice, gender and climate migration in the eu perspective. Exploring different roles of the eu commission, EU parliament, and the council.
Authors: Rosignoli Francesca
Published: July 2023

Climate migration is an emerging policymaking area not yet regulated by European Law. Given the absence of a legally-binding treaty governing this phenomenon, the scope of this study focuses on policy documents issued by the most relevant European Institutions: the EU Commission, EU Parliament, and the Council. Thanks to this document-based analysis, the present contribution will show the different roles the selected EU institutions played and whether they have a common denominator. The main findings show that despite the different ontologies and approaches, the selected EU institutions seem to converge into a significant securitization of climate migration, with scant attention to gender and environmental justice within the most relevant EU documents concerning migration and asylum. Indeed, such perspectives are more likely to be mentioned in EU policy documents dedicated to gender but are not integrated into the migration policies where they would matter. A detailed analysis of the New Pact on Migration and Asylum reveals its substantially gender and environmental justice-blind approach despite the gender mainstreaming ontology that has been invoked in numerous policy documents largely focused on gender.
NGS analysis of unexplained Community-Acquired Pneumonia (CAP) cases in South Korea
Authors: Sooyeon Lim , Jae Kyung Lee , Han Sol Lee , Ji Yun Noh , Joon Young Song , Hee Jin Cheong , Woo Joo Kim
Published: July 2023

In general, pneumonia has known to be closely associated with respiratory infection of viruses, bacteria, fungi, and parasites. In South Korea, pneumonia is a leading cause of death that continues to threaten public health every year. Through the tertiary hospital-based influenza surveillance system in South Korea, nasopharyngeal swab specimens were obtained from patients with unexplained cases of Community-Acquired Pneumonia (CAP) between 2011 and 2017. After real-time PCR screening using respiratory viral panels, the samples were found negative for 16 common respiratory pathogens including adenovirus, influenza viruses, rhinovirus, respiratory syncytial virus, coronavirus, metapneumovirus, and parainfluenza viruses. The aim of this study was to investigate the patient microbiota and examine the etiology of CAP requiring hospitalization. The nasopharyngeal microbiome of adult patients during CAP was analyzed using Next-Generation Sequencing (NGS) on the Illumina MiSeq platform and a subsequent bioinformatics pipeline. Viral nucleic acids were nearly absent in the samples and failed to generate any sequence reads. On the other hand, samples were enriched with a diverse bacterial community, which was mainly comprised of Corynebacterium, Staphylococcus, Streptococcus, Haemophilus, Moraxella, Acinetobacter, and Rhizobium genera. Despite the diversity of bacterial composition, only a few dominant species with > 1% abundance were identified in each patient sample. Population analysis at the genus level showed that microbial diversity varied according to age, sex, and location.
Regular maintenance of human pluripotent stem cells v1
Authors: Yadavalli Narayana
Published: July 2023

This protocol describes the regular maintenance and passaging human iPSCs.
Nuclear cytoplasmic fractionation v1
Authors: Yadavalli Narayana
Published: July 2023

This protocol describes nuclear cytoplasmic fractionation.
Nuclei Isolation and Immunoprecipitation for 10X Sequencing v2
Authors: Caceres Lakme
Published: July 2023

This protocol is for isolating nuclei for downstream sequencing applications.
DQ-BSA assay v1
Authors: Yadavalli Narayana
Published: July 2023

This protocol describes the DQ BSA assay for measuring the lysosomal proteolytic activity.
New Media and Green Behaviour Campaign Through Corporate Social Responsibility Collaboration
Authors:   Universitas Sebelas Maret, Indonesia, Pujihartati Sri Hilmi , Nurhaeni Ismi Dwi Astuti ,   Universitas Sebelas Maret, Indonesia, Kartono Drajat Tri ,   Universitas Sebelas Maret, Indonesia, Demartoto Argyo ,   Universitas Sebelas Maret, Indonesia
Published: July 2023

This research delves into the role of new media in promoting green behaviour campaigns as part of community development programs supported by corporate social responsibility (CSR) initiatives. In particular, the program under investigation involves a collaboration between the community and the CSR division of Indaco Warna Dunia Company. Employing the sociology of communication analysis, this study aims to reveal the importance of new media platforms in disseminating environmental messages that resonate with the younger generation. In the current age of rapid communication and information exchange, new media has the potential to overcome the challenges posed by traditional channels and engage young people, who play a crucial role in driving social and environmental change. By leveraging new media, environmental messages can be effectively communicated to the youth, fostering a generation that is conscious of sustainable practices and environmental issues. To investigate the impact of new media on promoting green behaviour, this research utilised a single holistic case study methodology. The findings of this study indicate that social media, as a form of new media, can serve as a contemporary and effective means of disseminating environmental education. By utilising these platforms, green behaviour campaigns can reach a wider audience, inspire young people to adopt eco-friendly habits, and ultimately contribute to the development of environmentally-conscious communities through strategic CSR collaborations. Keywords: CSR, green behaviour, new media, Indaco, sociology.
The Effect of Influencer Engagement Rate in Increasing Followers of Instagram Official Account
Authors:   Sebelas Maret University, Indonesia, Monacho Benny Chandra , Slamet Yulius ,   Sebelas Maret University, Indonesia
Published: July 2023

The phenomenon of influencer marketing has grown rapidly in recent years. Instagram is considered one of the social media platforms that produce the highest number of influencer marketing, especially to reach Generation Y and Generation Z. Influencers are part of the marketing strategy, which is also used by brands to market their products. Several studies show that the engagement rate affects the desire to buy from followers of official Instagram accounts, and also make followers consider to buy products from the official Instagram account is the number of followers. Therefore, the main study of this research is to compare the effect of the engagement rate of Instagram influencers on increasing the number of followers of official brand accounts so that the resulting recommendations can be used in the next stage of the influencer marketing process. The research will be conducted using quantitative research methods. There are two types of variables, the dependent variable is the result of adding followers to the official account during the research period and the independent variable of this research is the engagement rate value of the influencer. The results show that the engagement rate of influencers has no effect on increasing followers on Instagram's official accounts, but the engagement rate value affects the percentage increase in the number of followers. This shows that the higher the engagement rate, the higher the percentage of additional followers. A significant increase 24.7 % in followers (account number) will occur on official accounts that have previously had more followers when doing influencer marketing. Keywords: Digital marketing, influencer, engagement rate, increased followers, marketing strategy.
Analysis of Mobile App Promotion Methods in the Gamedev Sphere (In Russ.)
Authors:   ITMO University, Izmailova A.A. , Budrin A.G. ,   ITMO University, Soldatova A.V. ,   ITMO University
Published: July 2023

This study aims to review and systematize the methods, tools and channels for mobile app promotion in the gamedev sphere. The entertainment industry is becoming increasingly digitalized and consumers are actively immersed in the world of mobile apps. The last few years have seen an incredible speed of change, both in terms of consumer behavior and promotional methods. The disappearance of the biggest traffic channels and changes in the legal environment over the last two years have encouraged companies to rethink their marketing strategies, promotion methods and channels used in order to maintain marketing effectiveness. The aim of the study is to deepen knowledge about the specifics of mobile application promotion methods in gamedev, reviewing current promotion tools and channels in the new reality. The specific aspects of the application of such promotion methods and tools as targeted advertising, contextual advertising, media advertising, ASO-optimization, app localization, as well as Influencer Marketing and SMM to the gamedev sphere have been described. The most relevant channels for attracting mobile app users in the context of high speed of gamedev market transformation were studied.
Assessment of the Quality of Entrepreneurial Innovation Projects of Russian Universities Based on a Machine Learning Model (In Russ.)
Authors:   ITMO University, Potsulin A.S. , Sergeeva I.G. ,   ITMO University
Published: July 2023

By 2030 it has been planning to support more than 30 thousand entrepreneurial and innovative projects of students and graduate students, this idea has become one of the government initiatives in the sphere of social and economic development of Russia. It is known that the pursuit of quantity can lead to a decrease in quality and the subsequent closure of innovative projects. However now there is no generally accepted methodology that allows preliminary assessment of the quality of innovative projects of universities. The presented study empirically illustrates the ap-plication of machine learning methods for assessing the quality of entrepreneurial innovation projects of universities and predicting their success. The study analyzed the main reasons for the closure of Russian startups, resulting in a list of criteria for evaluating the quality of university innovation projects. A survey of managers of innovative projects implemented in universities in St. Petersburg, Moscow and Vladivostok was conducted, on the basis of which a sample was formed for training the quality assessment model of entrepreneurial innovation projects. As a result of the study, a machine learning model was built and trained, and its accuracy was evaluated. Random Forest was chosen as the ma-chine learning method; the reason for its choice was its high accuracy, resistance to outliers, and ability to process data with a large number of features and classes. The application of these results will simplify the process of assessing the quality of entrepreneurial innovation projects and allow predicting their success. Assessing the quality of entrepreneuri-al innovation projects at the early stages of their implementation will be beneficial not only for project managers, but also for business incubators at universities.
Blockchain as a Tool for Integrating Various Areas of Economic Activity (In Russ.)
Authors:   ITMO University, Loginov N.A. , Budrina E.V. ,   ITMO University
Published: July 2023

This paper describes the impact of blockchain on organizations in various fields of activity. In order to describe the impact in detail and correctly, the blockchain process is described, which is divided into several stages. In addition, the architecture of the blockchain technology implementation system is displayed. Due to the fact that blockchain technology correlates with other electronic centralized systems, its distinctive features are listed. Based on these features, there is a change and simplification of business processes in organizations. However, this technology has both advantages and disadvantages which will disappear over time. There are certain requirements for the blockchain, the fulfillment of which will allow creating a working version of a decentralized system. Thus, this work confirms the pos-sibility of integrating blockchain technology into various fields of activity.
Using Foresight Marketing Methods when Developing a Brand Strategy (In Russ.)
Authors:   ITMO University, Chernyavskaya E.I. , Soloveva D.V. ,   ITMO University
Published: July 2023

This study is aimed at reviewing and systematizing the methods of brand strategy development based on the concept of foresight marketing in the senses. It is important for brands to follow modern trends, as well as the needs of customers in order to hold key positions in the market, increase the number of consumers, increase their brand loyalty, the level of trust, and gradually expand the geography of business. The purpose of the study is to deepen knowledge about the concept of foresight marketing and develop a brand strategy based on it. The paper considers several approaches to the concept of «foresight», its main methods are given. The approaches of thinking about the future are considered and a correlation between strategy and foresight is found. The key aspects of the use of foresight, as well as the key methods of foresight marketing are identified. The author proposes a unified method for developing a brand strategy based on the use of the concept of foresight marketing, which is relevant for modern brands, and can also be adapted to various conditions. Using the proposed approach will allow brands to create strategies that will be ahead of the current time and help companies adapt to changes in the environment faster than competitors, as well as make it easier to adapt to a new turbulent future.
Development of Information Support for the Student Project Management System (In Russ.)
Authors:   ITMO University, Afanasev A.V. , Gorlushkina N.N. ,   ITMO University, Shutov D.E. ,   ITMO University
Published: July 2023

The article discusses the systems for organizing project management, which are used in the educational process in the preparation of specialists for the IT sphere, who are able to manage and manage the creation of new products. The requirements for systems with which you can manage the organization of the design process are considered. An information system is proposed for managing students' project activities, providing network interaction in the implementation of educational projects and monitoring this process. The information system allows you to coordinate the actions of students of different courses and groups, monitor the progress of work and evaluate the contribution to the work of each student.
SECONDARY PHRASE-FORMATION PROCESSES IN THE ENGLISH LANGUAGE
Authors:   Volodymyr Vynnychenko Central Ukrainian State University, ARDELIAN Olena
Published: July 2023

The article provides a description of secondary phrase-forming processes in the English language, which result in the emergence of usual derived phraseological units. The typology of these processes has been examined according to structural and semantic criteria. According to structural criteria, secondary phrase-forming processes can be classified into intrastructural (where the derivative and creative unit have the same structure) and interstructural (involving units with different structures). The relevance of the study is determined by both active secondary phraseology in the English language and interest in derived phraseological units, as well as the need to provide generalization and explanation regarding the process of formation of a new phrase based on an existing one. The aim of the work is the study of secondary phrase formation as one of the language mechanisms for describing the phraseological system in its dynamic state and development. In the course of the study, all possible changes in the expression plan of the creative phraseological unit that occur in the process of creating a new phraseological unit have been summarized and correlated with changes in the content plan. It has been established that the formation of a new phraseological unit is possible if the meaning of the derived unit differs from the value of the original unit. The meaning of a derived phraseological expression is created based on an existing linguistic sign, therefore it necessarily incorporates in a certain way the meaning of the creative unit. The common elements of the structure of the creative and derived phraseological units create a material basis for the semantic correlation between the units. The process of secondary phrase formation leads to the emergence of phraseological units with new structural and semantic indicators. It is simultaneously associated with changes in both form and content. The analyzed linguistic material has demonstrated that based on the same event or plot, different phraseological nominations can arise, including new meanings of already existing units.
THE SCORE OF PROBLEM-THEMATIC COMPLEXES IN I. MCEWAN’S NOVEL “LESSONS” (2022): THE TOPIC OF “THE WAY OF THE HERO”
Authors:   The National Academy of Sciences of Ukraine, DROZDOVSKYI Dmytro
Published: July 2023

In the paper, the author explores the problem-thematic landscape explicated in Ian McEwan’s post-postmodern novel “Lessons” (2022). Philosophical aspects of the literary work by the British writer have been studied, in particular, the representation of environmental issues that shape the worldview of the protagonist (Roland). The genre specification of the novel has been clarified, and the genre forms exploited in the novel Lessons have been outlined. Emphasis is placed on the reinforcement of the topics of romantic discourse (with a focus on the metaphysical/transcendental phenomenon represented through music), which is a general typological feature of the British post-postmodern novel. The scope of problem-thematic complexes that define the existential and epistemological landscape of the novel has been determined: the interaction of erotic and thanatological aspects in the life of the protagonist, problems of sexuality, the motif of Roland’s coming of age, awareness of the planetary threat to humanity, the fragility of human life in the second half – end of the 20th century. The specific events in Roland’s life are compared with historical, social and political events, particularly in terms of how the specific and general interact in the space of the novel. Emphasis is placed on the forms of explication of the road motif in McEwan’s Lessons, which involves the sub-motif of self-discovery, rethinking mistakes and self-improvement, etc. In this way, the thematic aspects of the novel reveal the meta-genre pattern of mystery, which opposes the carnivalization of reality in postmodern novels. The protagonist understands the crisis of political institutions and the danger of an ideology that seeks to conquer the individual at all costs. The policy of the USSR indirectly affects the formation of the worldview of the young British man, Roland, giving him the opportunity to accept for the first time his own finitude through the understanding of a hypothetically possible nuclear explosion. The second global problem discussed in the novel as a consequence of the Soviet ideology, is the Chernobyl disaster. The novel reveals the stages of formation of existentially significant categories and values in the life of the protagonist. The detective plot, which revolves around the key intrigue in the novel, intersects with social criticism of power, political discourse in general, environmental policy, etc., combining skepticism and irony with Roland’s attempt to find out the essence of human beings: both physical and metaphysical.
DOĞRUDAN YABANCI YATIRIMLAR VE KARBONDİOKSİT EMİSYONU İLİŞKİSİ: TÜRKİYE İÇİN KİRLİLİK CENNETİ HİPOTEZİNİN DEĞERLENDİRİLMESİ
Authors: GÜR Betül
Published: July 2023

Ekonomik faaliyetlerin artması bir yandan çevre sorunlarını artırırken, diğer yandan çevresel sorunlardaki artış ekonomik gelişmeyi olumsuz etkilemektedir. Bu nedenle, sürdürülebilir bir ekonomik gelişmenin sağlanmasında çevresel kaynakların etkin kullanımı son derecede önemlidir. Ülkelerin büyüme arzusu ile gerçekleştirmiş oldukları üretim ve doğrudan yabancı yatırımları (DYY) ülkelerine çekebilmek için uyguladığı politikalar dünya genelinde karbondioksit salınımını artırmaktadır. Artan karbondioksit miktarı da çevresel bozulmaya yol açmaktadır. Böylece, gerçekleşen sermaye yatırımlarının ekonomiye olan etkilerinin yanı sıra çevresel etkileri de araştırılması gereken konulardandır. Yabancı sermaye yatırımlarının CO2 emisyon düzeyi üzerine olan etkisi yatırım yapan ve yatırım yapılan ülkeye göre değişiklik gösterebilmektedir. Bu çalışmanın amacı, 1990-2017 yılları için Türkiye’ye yönelik kirlilik cenneti hipotezinin yapısal kırılmalı eşbütünleşme Maki (2012) testi ve kısa dönem hata düzeltme modeli yardımıyla sınanmasıdır. Analiz sonucunda, DYY ve CO2 salınımı arasında uzun dönemde düşük etkili pozitif yönde ilişki ve kısa dönemde daha yüksek düzeyde pozitif yönde ilişki belirlenmiştir. Sonuç olarak, kirlilik cenneti hipotezi doğrulanmıştır.
Efficiency of antiseptic agents for treatment of autogenous dentinal blocks
Authors: Le Thanh H. , Drobyshev Alexey Yu. , Redko Nikolay A. , Tsarev Viktor N. , Podporin Mikhail S.
Published: July 2023

BACKGROUND: Autogenous material is currently one of the most common and effective materials used for bone grafting. In recent years, materials based on extracted teeth have attracted attention. When analyzing modern articles, all authors agree that before using autogenous dentinal material, it is necessary to carry out antiseptic treatment to prevent possible complications.
AIM: A comparison was made of various antiseptic agents for the treatment of autogenous dentinal blocks with subsequent osteoplastic operations in the pre-implantation period.
MATERIALS AND METHODS: At the Department of Maxillofacial and Plastic Surgery of the Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, 43 teeth were removed for orthodontic indications, the teeth were processed mechanically and fragmented into 125 autogenous dentinal blocks. Then they were treated with antiseptic agents (0.01% Miramistin solution, 95% ethyl alcohol solution, 0.05% and 2% chlorhexidine solution) for 15 min and were sent to the Department of Microbiology, Virology, Immunology of the Moscow State University of Medicine and Dentistry named after A.I. Evdokimov for the isolation of microbial cultures.
RESULTS: The use of antiseptic agents showed a significant reduction in microbial contamination compared with the control group, which did not undergo antiseptic treatment, which indicates the effectiveness of the treatment of extracted teeth before using it as an osteoplastic material for bone grafting.
CONCLUSION: Autogenous dentinal blocks must be processed before being used as an osteoplastic material.
Implantation microenvironment in chronic endometritis
Authors: Polina M. L. , Vityazeva I. I. , Ordiyants I. M. , Lebedeva M. G. , Shelenina L. A. , Zakharova P. N. , Douglas N. I.
Published: July 2023

Objective. To study the immune patterns of the endometrium in women with infertility of uterine genesis in the phase of "implantation window".
Materials and methods. Forty-two infertile women of reproductive age were prospectively examined. At the first stage, the contingent of women was divided into groups in accordance with the causes of infertility diagnosed before the current treatment: with chronic endometritis (CE) (n = 10); with tubal peritoneal infertility (TPI) (n = 32). A comprehensive examination of women included sonography of pelvic organs, hysteroscopy, examination of endometrial material in the period of the "implantation window" (morphological, immunohistochemical, real time (RT) PCR study,). The resulting for distinguishing molecular phenotypes of chronic inflammation (n = 30) and "normal" endometrium (n = 12) were the data of immunohistochemical studies of the immune profile (in the glandular epithelium and stromal cells (TNF-, IL-10, NRF2, GM-CSF and CXCL16), in the glandular epithelium BCA1, in the stroma TGF-) compared with the indicators of healthy fertile women (control group, n = 10).
CE was verified based on pathomorphological and immunohistochemical studies (CD 138+).
Results. Structural features of the endometrium in women with CE in the phase of the "implantation window" corresponded to the average stage of secretion in 36.4 %; variants of "out-of-phase" were identified in 63.6 % (late stage of the proliferation phase (16.7 %), dissociated development (13.3 %), early stage of the secretion phase (43.3 %)).
Molecular characteristics of the immunologically tolerant endometrium, favorable for implantation, are determined by the balanced production of pro-and anti-inflammatory cytokines, growth factors and chemokines.
Aggressive "microenvironment" in the endometrium of women with the phenotype of chronic inflammation was determined by the dominant of proinflammatory cytokines of the Th1/Th17 profile (an increase in comparison with the control of the expression level of TNF- and GM-CSF by 1.1 times and 1.2 times, in the glandular epithelium of chemokines CXCL16 and BCA1 by 1.2 times, CXCL16 in the stroma in 1.2 times) on the background of reduced production of protective factors (TGF- (1 point), IL-10 (in the glandular epithelium by 2 times, in the stroma by 1.8 times), NRF2.
Conclusions. Different molecular characteristics of the endometrium in women with TPI and CE determine the heterogeneity of potencies for blastocyst implantation.
Difficulty of diagnostics and efficiency of pathogenetic therapy of paroxysmal nocturnal hemoglobinuria (clinical case)
Authors: Barlamov P. N. , Vasilyeva E. R. , Zholobov V. G.
Published: July 2023

To show the features of the clinical picture of this orphan disease and demonstrate the effectiveness of a long-term pathogenetic treatment of this disease using the case history of a patient with paroxysmal nocturnal hemoglobinuria (PNH) as an example. Complaints, anamnesis, physical status, as well as laboratory and instrumental studies used for a patient with PNH were presented. Modern literature data on the diagnosis and treatment of PNH have been studied.
Complaints, anamnesis, physical status as well as laboratory and instrumental studies used for PNH patient were analyzed in comparison with the world literature data on this pathology.
A conclusion was made regarding the need for a wide coverage of the clinical picture and diagnosis of PNH. The effectiveness of a long-term (for 13 years) pathogenetic treatment of the classical form of PNH with eculizumab was shown.
Antitumor activity of solution of natural substance G-01 at the example of sarcoma M-1 when using adjuvant
Authors: Mirsaeva F. Z. , Garaishin Rustam M. , Kzyrgalin Sh. R. , Kitapova R. R. , Kostromina D. A. , Garaishina D. R. , Zaleev T. R.
Published: July 2023

Objective. To study the properties of the G-01 solution with an aluminum hydroxide-based adjuvant singly injected, while changing the concentration of the solution.
Materials and methods. The model of a transfused tumor (Sarcoma M-1) shows the antitumor activity of various concentrations of a solution of natural origin G-01 with the presence of an adjutant.
Results. The prospect of using G-01 solution in medicine as a preventive agent was established. To study the properties of a solution of G-01 with an adjuvant based on aluminum hydroxide singly injected, we found while changing the concentration of the solution that an immune response of different intensity can be induced to the same antigen, depending on the dose and multiplicity of the administered antigen.
Conclusions. In our study, which investigated the effect of G-01 solution on the body of mongrel albino white rats of the "Wistar" line in different concentrations, an optimal 15 % concentration of G-01 solution was found to have a pronounced effect on the immune system, causing the greatest antitumor activity.
Biotropic effects of geomagnetic disturbance in middle latitudes: psychological aspects of the problem
Authors: Oskolkova A. I. , Parshina S. S. , Kargina N. A. , Polidanov Maxim A. , Kondrashkin I. E. , Afanasyeva T. N. , Olenko E. S. , Belousova K. O.
Published: July 2023

Objective. To identify the individual psychological features and forms of stress coping in volunteers, participating in one of the stages of latitudinal monitoring Geliomed and living in the middle latitudes depending on the presence of psychological sensitivity to the impact of geomagnetic disturbance.
Materials and methods. Fifty-seven rather healthy male and female volunteers (mean age 42.3 (39.6; 47.5) years), living in the middle latitudes (Saratov city) were examined using the Spielberger Hanin Anxiety Test, the Haim Stress Coping Behavior Test and projective psychogeometrical test. Based on matching pick values of reactive anxiety and Kr-index (integral geomagnetic disturbance index), all volunteers were divided into two groups: group I those having psychological sensitivity to the impact of heliogeomagnetic factors and group II without the latter.
Results. The standard personal features of the observed persons were found to depend on the presence or absence of psychological sensitivity to the changes in geomagnetic disturbance and are reflected in the peculiar features of the stress-coping behavior formed by them. The volunteers of group I were less effective in the behavior sphere, they more often analyzed problems and suppressed their emotions compared with those of group II.
Conclusions. Thus, the persons having psychological sensitivity to the changes in geomagnetic disturbance require psychological correction of the established changes to decrease risk for the development of neuroses and psychological pathology.
Prevalence of bronchopulmonary dysplasia in infants with very low body weight and extremely low body weight in Perm Krai according to the data of catamnesis department of Perinatal center
Authors: Bakhmetieva Oksana B. , Permyakova Maria A. , Okunev Sergey L. , Mamunts Maria A.
Published: July 2023

Objective. To analyze the prevalence of bronchopulmonary dysplasia (BPD) in the city of Perm and Perm Krai, to state the prevalence dynamics for 3 years and BPD prevalence among infants with very low body weight (VLBW) and extremely low body weight (ELBW) from 2021 to 2021.
Materials and methods. Examination of 271 patients aged 0 to 3 years and assessment of clinico-anamnestic, laboratory, instrumental, X-ray data according to diagnostic standards and protocols was carried out.
Results. The number of infants diagnosed BPD in the group of preterm newborns was detected to decrease despite the fact that the quantity of preterm labors in Perm Krai is at the same level.
Conclusions. In Perm Krai, for the recent 3 years there is a tendency to reduction in the frequency of BPD formation in infants with VLBW as well as decrease in the share of severe BPD forms among premature infants.
A comparative study of solitary and teacher-led pre-task planning effect on EFL university learners’ writing performance: A case of an online platform amidst COVID-19
Authors: Zohoorian Zahra
Published: July 2023

Many educational institutions turned to the employment of online platforms during the Corona crisis. However, there were concerns for the students’ solitary plans of learning as in many parts of the world students did not have the experience of such online courses. This study compared the effect of a solitary pre-task intervention with a teacher-led pre-task planning on the Iranian EFL learners’ writing performance during COVID-19. Besides, it investigated the patterns of improve-ment in writing through an 8-session treatment conducted through Skype. Having employed a qua-si-experimental design through repeated measures, the researcher sought voluntary participation of 40 Iranian EFL university students who were randomly assigned to the control and experimental groups. The intervention included the instruction of seven types of paragraphs, which led to a writ-ten task as their writing performance. The repeated measures ANOVA and t-test results confirmed that both teacher-led pre-task planning and solitary pre-task planning elicited a statistically signifi-cant improvement within groups in students’ writing scores from the first session to the last session with an exception of the very last session for the solitary group which could be due to lack of inter-nal motivation. There was no significant difference between the two groups in their writing perfor-mance leading to the conclusion that solitary pre-task planning has been as effective as teacher-led. Thus, both types of pre-task planning can be operative in enhancing learners’ writing performance in a virtual environment.
A Comparison of Cosmetic Outcome of Periumbilical versus Intraumbilical Incision in Laparoscopic Appendectomy and Cholecystectomy-A One Year Randomised Controlled Trial
Authors: Keerthi M. Sravya , Kore S. S. Shimi , Togale Manoj D.
Published: July 2023

Laparoscopic surgeries are advantageous over open surgeries in terms of minimal tissue handling, earlier return of bowel function, less postoperative pain, better cosmesis, lesser duration of hospital stay, earlier return to full activity and decreased overall cost. The incidence of bowel injuries is 0.13%, vascular injuries is 0.05-2% and abdominal wall vascular injuries 0.2-2%. Therefore, safe abdominal entry in laparoscopy is a major concern. Considering the fact that initial entry to abdominal cavity is a blind procedure, there is no ideal entry site. Various entry points used are Umbilicus, Palmar’s point, Jain point, Lee-Huang point, etc. The current study aimed to compare the better cosmetic outcome between trans umbilical and periumbilical incision for primary port insertion in cases of Laparoscopic Appendicectomy and Laparoscopic Cholecystectomy. This is a one year RCT done in Department of General Surgery, KLEs Dr.Prabhakar Kore Hospital and Medical Research Centre, Belagavi, from January 2022-December 2022. A total of 100 patients operated for laparoscopic appendectomy and laparoscopic cholecystectomy were studied. The patients were divided into Group A and Group B based on type of incision taken either periumbilical or transumbilical. Postoperative cosmetic outcome was analyzed using POSAS score on post op day 3,7 and 1-month follow up. The results are statistically significant (P<0.05). Between the two incisions during POD# 3 and 7 there is significant difference between variables such as induration, erythema, SSI. In our study 3 cases had SSI in both the groups. Transumbilical incision has better cosmetic satisfaction compared to Periumbilical incision.
Optimizing Prophylactic Anticoagulation in Burns is Associated with Low Incidence of Venous Thromboembolic Complications
Authors: Mokline A , R Ghabara , Fraj H , Saad M Ben , Thabet L , Messadi AA
Published: July 2023

Venous thromboembolism (VTE) complications in burn patients are often under-diagnosed and potentially serious. Thromboprophylaxis in this population remains controversial. Objective: Assess the impact of optimizing prophylactic anticoagulation with enoxaparin in burn patients on the incidence of venous thromboembolism (VTE). Methods: Case-control study conducted in intensive burn care department in Tunisia during 24 months, (February 2018- February 2020). Patients were divided into 2 groups according to the prophylactic anticoagulation modalities: - G1 (Equation) receiving enoxaparine en mg/12H = 22.8 + (3.3 × % TBSA/10) + (1.89 × (weight in kg)/10)) - G2 (No équation) receiving enoxaparine at a dose of 0.5mg/kg, twice daily The goal of prophylactic antifactor Xa level was 0.2- 0.4 IU/ml Results: During study period, 216 patients were included divided into 2 groups: G1 (n= 108) et G2 (n= 108). The groups were comparable in terms of sex, age, weight, burned skin surface and VTE risk. Also, severity of the 2 groups was comparable regarding: smoke inhalation (p=0.46), use of mechanical ventilation (p=0.22), use of catecholamines within 48 hours (p=0.56) and rescue incision (p=0.77). In the equation group, initial dose of enoxaparin was 0.42± 0.12 mg. Target anti Xa was reached at the 1st dosage in 55 patients 55 (50.9%). The median final dose of enoxaparin required to reach the anti Xa target was 52 mg every 12 hours (range, 35-69 mg). No episodes of bleeding, thrombocytopenia, or heparin allergy were documented in either group. The incidence of VTE complications was higher in group 2 than in group 1 (8.3% versus 3.7%; p=0.001 with an OR=1.6 and CI [0.47-1.03]). The length of stay was longer for G2 with a significant difference (30 days vs 22 days; p=0.001). Mortality was the same for two groups. Conclusion: Optimizing thromboprophylaxis in severely burned patients with enoxaparin, using the enoxaparin dosing eqauation allows to achieve prophylactic anti-Xa level and to reduce risk of VTE complications.
Перевернутая технология обучения иностранному языку в техническом вузе
Authors: Власова И.В.
Published: July 2023

At the present stage, vocational education and training is undergoing transformation, structural changes and innovations due not only to the dynamism of the educational system, but also to the general increase in society’s requirements for the quality of learning processes [3]. Thus, the actual topic of modern pedagogical practice is the theme of building the educational environment and organization of students’ activities from the position of active interaction. In this connection, a number of problems arise based on the choice of optimal methods and techniques, forms, technologies and means of interaction of students during the educational process both with a teacher and in the process of collective-creative work [2; 8]. Thus, one of the promising and so far little-studied technologies is flipped learning. The aim of this article is to consider the main theoretical aspects of the practical application of flipped learning technology on the example of teaching a foreign language at a non-linguistic university.
LabERE – Andanças do Percurso Ocorrido e Incorporado, como Experiência de Atividade Remota em Grupo de Pesquisa
Authors: Saraiva Raimundo , Leão José Antônio Carneiro
Published: July 2023

Este estudo tem como objetivo descrever o processo utilizado para sensibilizar a continuidade das andanças realizadas de forma remota no âmbito de um Programa de Pós-Graduação Stricto Senso, durante o contexto da Pandemia do covid-19. A inquietação foi: como comunicar aos integrantes de um Grupo de Pesquisa, aspectos que levem a um percurso em presença contínua de construção do conhecimento, através da tríade sujeito-história-lugar, tendo em vista os projetos articuladores propostos por seus integrantes? O pressuposto apontou para a escolha da experiência literomusical, para dizer que, mesmo de forma remota, poderíamos estar integrados nas pesquisas do grupo. A metodologia esteve na utilização da ferramenta da Microsoft Teams, com reuniões em formato de laboratórios virtuais como produção formativa para construções espontâneas, em que se utilizou o método colaborativo, com 06 (seis) integrantes (Mestrandos e Doutores do Grupo na Universidade). O resultado apresentou participação interativa, desenvolvimento e alteridade que foi reverberada como forma de sensibilizar não apenas os pesquisadores do Projeto articulador RedePub, mas também dos demais membros que compõem o Grupo de Pesquisa, para a continuidade de seus estudos.
 
Palavras-chave: Corpografia. Educação científica. Laboratório de ensino remoto Emergencial. Pesquisa colaborativa.
Artificial division of a single administrative violation of license requirements in the sphere of management of apartment buildings
Authors:   Togliatti State University, Dulger A. V.
Published: July 2023

The paper deals with the problem of qualification and artificial division of a single administrative offense related to the presence of a debt to the public utilities suppliers by a managing company amounting double average monthly accrual when implementing the entrepreneurial activities on the management of apartment buildings with a gross violation of license requirements. The paper reveals the elements of administrative offense provided by part 3 of Art. 14.1.3 of the Code of the Russian Federation on Administrative Offenses. The author pays the particular attention to the analysis of small, but critically important judicial practice. Often the positions of regional courts contradict the positions of the RF Supreme Court and the general principles of administrative law. A problem of artificial division of a single offense into several independent ones was identified, since the disposition of part 3 of Art. 14.1.3 of the Code of the Russian Federation on Administrative Offenses is formulated inaccurately. Failure to fulfill the obligation for timely mutual settlements with a resource supplying organization may be erroneously qualified as several offenses, depending on the number of suppliers to whom the debt arose, and depending on the period of occurrence of such debt. Such an approach to law enforcement is found among the prosecution and housing supervision authorities. This problem leads to the repeated application of administrative punishment, when a single offense is qualified as several. The study identified general regularities in the approaches of superior courts, starting from the cassation level. These regularities allow determining the more precise conditions for qualifying gross violations of license requirements in the sphere of housing and utilities infrastructure in accordance with part 3 of Article 14.1.3 of the Code of the Russian Federation on Administrative Offenses.
Особенности аутсорсинга в сфере обеспечения лечебным питанием пациентов в оздоровительных учреждениях
Authors: Бакулина Е. А.
Published: July 2023

За последние несколько лет аутсорсинг лечебного питания получил достаточно широкое распространение среди медицинских организаций, однако алгоритм его работы еще не до конца сформирован и понятен. Его суть в передаче непрофильных функций (в данном конкретном случае – приготовлении диетических блюд) сторонней организации, имеющей для этого необходимые ресурсы, на основе долгосрочного договора. Технические навыки и наличие высококвалифицированного персонала субподрядчиков – важнейшая причина, по которой руководители медицинских организаций обращаются к ним за услугами лечебного питания на аутсорсинге. Еще одна причина – стремление повысить уровень эффективности и снизить затраты на непрофильную деятельность – приготовление здоровой пищи. Как действовать, на что обратить внимание при отработке аутсорсинга? Рассмотрим эти вопросы последовательно, начиная с общих понятий и заканчивая определением конкретных позиций при формировании договорных отношений.