bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanozyme as a rising star for metabolic disease management
Authors: Wang Yanan , He Xiaoyun , Huang Kunlun , Cheng Nan
Published: May 2024

Nanozyme, characterized by outstanding and inherent enzyme-mimicking properties, have emerged as highly promising alternatives to natural enzymes owning to their exceptional attributes such as regulation of oxidative stress, convenient storage, adjustable catalytic activities, remarkable stability, and effortless scalability for large-scale production. Given the potent regulatory function of nanozymes on oxidative stress and coupled with the fact that reactive oxygen species (ROS) play a vital role in the occurrence and exacerbation of metabolic diseases, nanozyme offer a unique perspective for therapy through multifunctional activities, achieving essential results in the treatment of metabolic diseases by directly scavenging excess ROS or regulating pathologically related molecules. The rational design strategies, nanozyme-enabled therapeutic mechanisms at the cellular level, and the therapies of nanozyme for several typical metabolic diseases and underlying mechanisms are discussed, mainly including obesity, diabetes, cardiovascular disease, diabetic wound healing, and others. Finally, the pharmacokinetics, safety analysis, challenges, and outlooks for the application of nanozyme are also presented. This review will provide some instructive perspectives on nanozyme and promote the development of enzyme-mimicking strategies in metabolic disease therapy.

Graphical Abstract
Adjuvant chemotherapy omission after pancreatic cancer resection: a French nationwide study
Authors: Poiraud Charles , Lenne Xavier , Bruandet Amélie , Theis Didier , Bertrand Nicolas , Turpin Anthony , Truant Stephanie , El Amrani Mehdi
Published: May 2024

Background

Adjuvant chemotherapy (AC) improves the prognosis after pancreatic ductal adenocarcinoma (PDAC) resection. However, previous studies have shown that a large proportion of patients do not receive or complete AC. This national study examined the risk factors for the omission or interruption of AC.

Methods

Data of all patients who underwent pancreatic surgery for PDAC in France between January 2012 and December 2017 were extracted from the French National Administrative Database. We considered “omission of adjuvant chemotherapy” (OAC) all patients who failed to receive any course of gemcitabine within 12 postoperative weeks and “interruption of AC” (IAC) was defined as less than 18 courses of AC.

Results

A total of 11 599 patients were included in this study. Pancreaticoduodenectomy was the most common procedure (76.3%), and 31% of the patients experienced major postoperative complications. OACs and IACs affected 42% and 68% of the patients, respectively. Ultimately, only 18.6% of the cohort completed AC. Patients who underwent surgery in a high-volume centers were less affected by postoperative complications, with no impact on the likelihood of receiving AC. Multivariate analysis showed that age ≥ 80 years, Charlson comorbidity index (CCI) ≥ 4, and major complications were associated with OAC (OR = 2.19; CI95%[1.79–2.68]; OR = 1.75; CI95%[1.41–2.18] and OR = 2.37; CI95%[2.15–2.62] respectively). Moreover, age ≥ 80 years and CCI 2–3 or ≥ 4 were also independent risk factors for IAC (OR = 1.54, CI95%[1.1–2.15]; OR = 1.43, CI95%[1.21–1.68]; OR = 1.47, CI95%[1.02–2.12], respectively).

Conclusion

Sequence surgery followed by chemotherapy is associated with a high dropout rate, especially in octogenarian and comorbid patients.
Efficacy and safety of hepatic arterial infusion chemotherapy combined with lenvatinib and PD-1 inhibitors for advanced hepatocellular carcinoma with macrovascular invasion
Authors: Zhang Yufeng , Zhang Haiyan , Xu Haoqian , Wang Ying , Feng Long , Yi Fengming
Published: May 2024

Background and aims

The prognosis of hepatocellular carcinoma (HCC) with macrovascular invasion(MaVI)is poor, and the treatment is limited. This study aims to explore the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC), combined with lenvatinib and programmed cell death-1(PD-1) inhibitor in the first-line treatment of HCC with MaVI.

Methods

From July 2020 to February 2022, we retrospectively analyzed consecutive patients with HCC with MaVI who received hepatic arterial infusion FOLFOX(oxaliplatin, 5-fluorouracil, and leucovorin)combined with lenvatinib and PD-1 inhibitor. The efficacy was evaluated by RECIST 1.1. Kaplan-Meier was used to explore the overall survival and progression-free survival (PFS), and the COX regression model was used to analyze the risk factors of PFS. Adverse events (AEs) were evaluated according to CTCAE5.0.

Results

Thirty-two patients with HCC complicated with MaVI were recruited from the Second Affiliated Hospital of Nanchang University. Among the patients treated with HAIC combined with lenvatinib and PD-1 inhibitor, ten patients (31.25%) got partial response, eighteen patients (56.25%) maintained stable disease and four patients (12.50%) suffered progressive disease during follow-up; and objective response rate was 31.25%, and disease control rate was 87.5%. The median PFS was 179 days. Univariate and multivariate Cox analysis showed that the extrahepatic metastases and Child-Pugh score were independent prognostic factors of PFS. Twenty-two (68.75%) patients suffered adverse reactions. The main AEs were elevated transaminase (46.87%), thrombocytopenia (40.63%), hypoalbuminemia (28.13%), nausea and vomiting (21.88%), leukopenia (18.76%), abdominal pain (15.63%), hypertension (15.63%) and fever (15.63%). There were seven cases (21.88%) that had grade 3 or above AEs; Among them, two cases with elevated transaminase (6.25%), leukopenia, thrombocytopenia, nausea and vomiting, abdominal pain, and diarrhea occurred in one case respectively. Moreover, no treatment-related death was observed.

Conclusions

Hepatic arterial infusion of FOLFOX combined with lenvatinib and PD-1 inhibitor as the first-line treatment for HCC complicated with MaVI is effective, and adverse reactions are tolerable.
Gonadotropin elevation is ootoxic to ovulatory oocytes and inhibits oocyte maturation, and activin decoy receptor ActRIIB:Fc therapeutically restores maturation
Authors: Bernstein Lori R. , Mackenzie Amelia C. L. , Chaffin Charles L. , Lee Se-Jin , Kraemer Duane C. , Merchenthaler Istvan
Published: May 2024

Background

Elevated FSH often occurs in women of advanced maternal age (AMA, age ≥ 35) and in infertility patients undergoing controlled ovarian stimulation (COS). There is controversy on whether high endogenous FSH contributes to infertility and whether high exogenous FSH adversely impacts patient pregnancy rates.

Methods

The senescence-accelerated mouse-prone-8 (SAMP8) model of female reproductive aging was employed to assess the separate impacts of age and high FSH activity on the percentages (%) of viable and mature ovulated oocytes recovered after gonadotropin treatment. Young and midlife mice were treated with the FSH analog equine chorionic gonadotropin (eCG) to model both endogenous FSH elevation and exogenous FSH elevation. Previously we showed the activin inhibitor ActRIIB:Fc increases oocyte quality by preventing chromosome and spindle misalignments. Therefore, ActRIIB:Fc treatment was performed in an effort to increase % oocyte viability and % oocyte maturation.

Results

The high FSH activity of eCG is ootoxic to ovulatory oocytes, with greater decreases in % viable oocytes in midlife than young mice. High FSH activity of eCG potently inhibits oocyte maturation, decreasing the % of mature oocytes to similar degrees in young and midlife mice. ActRIIB:Fc treatment does not prevent eCG ootoxicity, but it restores most oocyte maturation impeded by eCG.

Conclusions

FSH ootoxicity to ovulatory oocytes and FSH maturation inhibition pose a paradox given the well-known pro-growth and pro-maturation activities of FSH in the earlier stages of oocyte growth. We propose the FOOT Hypothesis (“FSH OoToxicity Hypothesis), that FSH ootoxicity to ovulatory oocytes comprises a new driver of infertility and low pregnancy success rates in DOR women attempting spontaneous pregnancy and in COS/IUI patients, especially AMA women. We speculate that endogenous FSH elevation also contributes to reduced fecundity in these DOR and COS/IUI patients.

Restoration of oocyte maturation by ActRIB:Fc suggests that activin suppresses oocyte maturation in vivo. This contrasts with prior studies showing activin A promotes oocyte maturation in vitro. Improved oocyte maturation with agents that decrease endogenous activin activity with high specificity may have therapeutic benefit for COS/IVF patients, COS/IUI patients, and DOR patients attempting spontaneous pregnancies.
Exosome-transported circ_0061407 and circ_0008103 play a tumour-repressive role and show diagnostic value in non-small-cell lung cancer
Authors: Chen Zhenhua , Ma Xinyi , Chen Ziyuan , Chen Wei , Li Leyi , Lin Yichen , Hu Yulin , Shang Yue , Zhao Yikai , He Jinxian , Zhou Chengwei , Meng Xiaodan
Published: May 2024

Background

Circular RNAs (circRNAs), one of the major contents of exosomes, have been shown to participate in the occurrence and progression of cancers. The role and the diagnostic potential of exosome-transported circRNAs in non-small-cell lung cancer (NSCLC) remain largely unknown.

Methods

The NSCLC-associated exosomal circ_0061407 and circ_0008103 were screened by circRNA microarray. The role of circ_0061407 and circ_0008103 in NSCLC was examined in vitro and in vivo. The encapsulation of the two circRNAs into exosomes and the transport to recipient cells were observed by confocal microscopy. The effects of exosome-transported circ_0061407 and circ_0008103 on recipient cells were investigated using a co-culture device. Bioinformatics analyses were performed to predict the mechanisms by which circ_0061407 and circ_0008103 affected NSCLC. The quantitative polymerase chain reaction was used to quantify the exosome-containing circ_0061407 and circ_0008103 in the serum samples of healthy, pneumonia, benign lung tumours, and NSCLC. The diagnostic efficacy was evaluated using receiver operating characteristic curves.

Results

The levels of circ_0061407 and circ_0008103 within exosomes were down-regulated in the serum of patients with NSCLC. The up-regulation of circ_0061407 and circ_0008103 inhibited the proliferation, migration/invasion, cloning formation of NSCLC cells in vitro and inhibited lung tumour growth in vivo. Circ_0061407 and circ_0008103 were observed to be packaged in exosomes and transported to recipient cells, where they inhibited the proliferation, migration/invasion, and cloning formation abilities of the recipient cells. Moreover, circ_0061407 and circ_0008103 might be involved in the progression of NSCLC by interacting with microRNAs and proteins. Additionally, lower serum exosomal circ_0061407 and circ_0008103 levels were associated with advanced pathological staging and distant metastasis.

Conclusions

This study identified two novel exosome-transported circRNAs (circ_0061407 and circ_0008103) associated with NSCLC. These findings may provide additional insights into the development of NSCLC and potential diagnostic biomarkers for NSCLC.
Postembryonic development and lifestyle shift in the commensal ribbon worm
Authors: Hookabe Natsumi , Ueshima Rei , Miura Toru
Published: May 2024

Background

Various morphological adaptations are associated with symbiotic relationships between organisms. One such adaptation is seen in the nemertean genus Malacobdella. All species in the genus are commensals of molluscan hosts, attaching to the surface of host mantles with a terminal sucker. Malacobdella possesses several unique characteristics within the order Monostilifera, exhibiting the terminal sucker and the absence of eyes and apical/cerebral organs, which are related to their adaptation to a commensal lifestyle. Nevertheless, the developmental processes that give rise to these morphological characteristics during their transition from free-living larvae to commensal adults remain uncertain.

Results

In the present study, therefore, we visualized the developmental processes of the internal morphologies during postembryonic larval stages using fluorescent molecular markers. We demonstrated the developmental processes, including the formation of the sucker primordium and the functional sucker. Furthermore, our data revealed that sensory organs, including apical/cerebral organs, formed in embryonic and early postembryonic stages but degenerated in the late postembryonic stage prior to settlement within their host using a terminal sucker.

Conclusions

This study reveals the formation of the terminal sucker through tissue invagination, shedding light on its adhesion mechanism. Sucker muscle development likely originates from body wall muscles. Notably, M. japonica exhibits negative phototaxis despite lacking larval ocelli. This observation suggests a potential role for other sensory mechanisms, such as the apical and cerebral organs identified in the larvae, in facilitating settlement and adhesive behaviors. The loss of sensory organs during larval development might reflect a transition from planktonic feeding to a stable, host-associated lifestyle. This study also emphasizes the need for further studies to explore the phylogenetic relationships within the infraorder Amphiporiina and investigate the postembryonic development of neuromuscular systems in closely related taxa to gain a more comprehensive understanding of ecological adaptations in Nemertea.
Redefining Debt-to-Health, a triple-win health financing instrument in global health
Authors: Hu Yunxuan , Wang Zhebin , Zhou Shuduo , Yang Jian , Chen Ying , Wang Yumeng , Xu Ming
Published: May 2024

Background

As a recognized win–win-win approach to international debt relief, Debt-to-Health(D2H)has successfully translated debt repayments into investments in health-related projects. Although D2H has experienced modifications and periodic suspension, it has been playing an increasingly important role in resource mobilization in public health, particularly for low-and middle-income countries deep in debt.

Main text

D2H, as a practical health financing instrument, is not fully evidenced and gauged by academic literature though. We employed a five-step scoping review methodology. After posing questions, we conducted comprehensive literature searches across three databases and one official website to identify relevant studies.We also supplemented our research with expert interviews. Through this review and interviews, we were able to define the concept and structure of D2H, identify stakeholders, and assess its current shortcomings. Finally, we proposed relevant countermeasures and suggestions.

Conclusion

This paper examines the D2H project's implementation structure and influencing variables, as well as the current research plan's limitations, with a focus on the role health funding institutions have played during the project's whole life. Simultaneously, it examines the interdependencies between debtor nations, creditor nations, and health financing establishments, establishing the groundwork for augmenting and revamping D2H within the ever-changing worldwide context of health development assistance.
A qualitative study of experiences with physical activity among people receiving opioid agonist therapy
Authors: Furulund Einar , Carlsen Siv-Elin Leirvåg , Druckrey-Fiskaaen Karl Trygve , Madebo Tesfaye , Fadnes Lars T , Lid Torgeir Gilje
Published: May 2024

Background

Physical or mental health comorbidities are common among people with substance use disorders undergoing opioid agonist therapy. As both a preventive and treatment strategy, exercise offers various health benefits for several conditions. Exercise interventions to people with substance use disorders receiving opioid agonist therapy are limited. This study aims to explore experiences with physical activity, perceived barriers, and facilitators among people receiving opioid agonist therapy.

Method

Fourteen qualitative interviews were conducted with individuals receiving opioid agonist therapy in outpatient clinics in Western Norway.

Results

Most were males in the age range 30 to 60 years. Participants had diverse and long-term substance use histories, and most received buprenorphine-based opioid agonist therapy. The identified themes were (1) Physical limitations: Participants experienced health-related problems like breathing difficulties, pain, and reduced physical function. (2) Social dynamics: Social support was essential for participating in physical activities and many argued for group exercises, but some were concerned about the possibility of meeting persons influenced by substances in a group setting, fearing temptations to use substances. (3) Shift in focus: As participants felt the weight of the health burden, their preference for activities shifted from sports aiming for “adrenaline” to a health promoting focus. (4) COVID-19’s impact on exercise: because of the pandemic, group activities were suspended, and participants described it as challenging to resume. (5) Implementation preferences in clinics: Not interfering with opioid medication routines was reported to be essential.

Conclusion

This study offers valuable insights for the development of customized exercise interventions aimed at enhancing the health and well-being of patients undergoing opioid agonist therapy. These findings underscore the significance of addressing social dynamics, overcoming physical limitations, and implementing a practical and effective exercise regimen.
Scoping review of the recommendations and guidance for improving the quality of rare disease registries
Authors: Tarride JE , Okoh A. , Aryal K. , Prada C. , Milinkovic Deborah , Keepanasseril A. , Iorio A.
Published: May 2024

Background

Rare disease registries (RDRs) are valuable tools for improving clinical care and advancing research. However, they often vary qualitatively, structurally, and operationally in ways that can determine their potential utility as a source of evidence to support decision-making regarding the approval and funding of new treatments for rare diseases.

Objectives

The goal of this research project was to review the literature on rare disease registries and identify best practices to improve the quality of RDRs.

Methods

In this scoping review, we searched MEDLINE and EMBASE as well as the websites of regulatory bodies and health technology assessment agencies from 2010 to April 2023 for literature offering guidance or recommendations to ensure, improve, or maintain quality RDRs.

Results

The search yielded 1,175 unique references, of which 64 met the inclusion criteria. The characteristics of RDRs deemed to be relevant to their quality align with three main domains and several sub-domains considered to be best practices for quality RDRs: (1) governance (registry purpose and description; governance structure; stakeholder engagement; sustainability; ethics/legal/privacy; data governance; documentation; and training and support); (2) data (standardized disease classification; common data elements; data dictionary; data collection; data quality and assurance; and data analysis and reporting); and (3) information technology (IT) infrastructure (physical and virtual infrastructure; and software infrastructure guided by FAIR principles (Findability; Accessibility; Interoperability; and Reusability).

Conclusions

Although RDRs face numerous challenges due to their small and dispersed populations, RDRs can generate quality data to support healthcare decision-making through the use of standards and principles on strong governance, quality data practices, and IT infrastructure.
DCAF1 interacts with PARD3 to promote hepatocellular carcinoma progression and metastasis by activating the Akt signaling pathway
Authors: Zhang Jinyao , Shi Yuze , Ding Ke , Yu Weiwei , He Jianbo , Sun Beicheng
Published: May 2024

Background

Hepatocellular carcinoma (HCC) is a fatal malignancy with poor prognosis due to lack of effective clinical interference. DCAF1 plays a vital role in regulating cell growth and proliferation, and is involved in the progression of various malignancies. However, the function of DCAF1 in HCC development and the underlying mechanism are still unknown. This study aimed to explore the effect of DCAF1 in HCC and the corresponding molecular mechanism.

Methods

Quantitative real-time PCR, Western blot and immunostaining were used to determine DCAF1 expression in tumor tissues and cell lines. Subsequently, in vitro and in vivo experiments were conducted to explore the function of DCAF1 in tumor growth and metastasis in HCC. Coimmunoprecipitation, mass spectrometry and RNA sequencing were performed to identify the underlying molecular mechanisms.

Results

In this study, we found that DCAF1 was observably upregulated and associated with poor prognosis in HCC. Knockdown of DCAF1 inhibited tumor proliferation and metastasis and promoted tumor apoptosis, whereas overexpressing DCAF1 yielded opposite effects. Mechanistically, DCAF1 could activate the Akt signaling pathway by binding to PARD3 and enhancing its expression. We also found that the combined application of DCAF1 knockdown and Akt inhibitor could significantly suppress subcutaneous xenograft tumor growth.

Conclusions

Our study illustrates that DCAF1 plays a crucial role in HCC development and the DCAF1/PARD3/Akt axis presents a potentially effective therapeutic strategy for HCC.

Graphical Abstract
Deficiency of histone deacetylases 3 in macrophage alleviates monosodium urate crystals-induced gouty inflammation in mice
Authors: Yang Qi-Bin , Zhang Meng-Yun , Yang Liu , Wang Jie , Mi Qing-Sheng , Zhou Jing-Guo
Published: May 2024

Background

Gout is caused by monosodium urate (MSU) crystals deposition to trigger immune response. A recent study suggested that inhibition of Class I Histone deacetylases (HDACs) can significantly reduce MSU crystals-induced inflammation. However, which one of HDACs members in response to MSU crystals was still unknown. Here, we investigated the roles of HDAC3 in MSU crystals-induced gouty inflammation.

Methods

Macrophage specific HDAC3 knockout (KO) mice were used to investigate inflammatory profiles of gout in mouse models in vivo, including ankle arthritis, foot pad arthritis and subcutaneous air pouch model. In the in vitro experiments, bone marrow-derived macrophages (BMDMs) from mice were treated with MSU crystals to assess cytokines, potential target gene and protein.

Results

Deficiency of HDAC3 in macrophage not only reduced MSU-induced foot pad and ankle joint swelling but also decreased neutrophils trafficking and IL-1β release in air pouch models. In addition, the levels of inflammatory genes related to TLR2/4/NF-κB/IL-6/STAT3 signaling pathway were significantly decreased in BMDMs from HDAC3 KO mice after MSU treatment. Moreover, RGFP966, selective inhibitor of HDAC3, inhibited IL-6 and TNF-α production in BMDMs treated with MSU crystals. Besides, HDAC3 deficiency shifted gene expression from pro-inflammatory macrophage (M1) to anti-inflammatory macrophage (M2) in BMDMs after MSU challenge.

Conclusions

Deficiency of HDAC3 in macrophage alleviates MSU crystals-induced gouty inflammation through inhibition of TLR2/4 driven IL-6/STAT3 signaling pathway, suggesting that HDAC3 could contribute to a potential therapeutic target of gout.
Continuous lipreading based on acoustic temporal alignments
Authors: Gimeno-Gómez David , Martínez-Hinarejos Carlos-D.
Published: May 2024

Visual speech recognition (VSR) is a challenging task that has received increasing interest during the last few decades. Current state of the art employs powerful end-to-end architectures based on deep learning which depend on large amounts of data and high computational resources for their estimation. We address the task of VSR for data scarcity scenarios with limited computational resources by using traditional approaches based on hidden Markov models. We present a novel learning strategy that employs information obtained from previous acoustic temporal alignments to improve the visual system performance. Furthermore, we studied multiple visual speech representations and how image resolution or frame rate affect its performance. All these experiments were conducted on the limited data VLRF corpus, a database which offers an audio-visual support to address continuous speech recognition in Spanish. The results show that our approach significantly outperforms the best results achieved on the task to date.
Demographic and economic inequality of antenatal care coverage in 4 African countries with a high maternal mortality rate
Authors: Belay Winini , Belay Amanuel , Mengesha Tariku , Habtemichael Mizan
Published: May 2024

Background

Maternal deaths are concentrated in low and middle-income countries, and Africa accounts for over 50% of the deaths. Women from socioeconomically disadvantaged households have higher morbidity and mortality rates and lower access to maternal health services. Understanding and addressing these inequalities is crucial for achieving the Sustainable Development Goals and improving maternal health outcomes. This study examines the demographic and economic disparities in the utilization of antenatal care (ANC) in four countries with high maternal mortality rates in Africa, namely Nigeria, Chad, Liberia, and Sierra Leone.

Method

The study utilised data from Demographic and Health Surveys (DHS) and Multiple Indicator Cluster Surveys (MICS) from Nigeria, Chad, Liberia, and Sierra Leone. The data was obtained from the Health Equity Assessment Toolkit (HEAT) database. The study examined ANC service utilisation inequality in four dimensions such as economic status, education, place of residence, and subnational region across different subgroups by using four summary measures (Difference (D), Absolute Concentration Index (ACI), Population Attributable Risk (PAR), and Population Attributable Factor (PAF)).

Result

A varying level of inequality in ANC coverage across multiple survey years was observed in Nigeria, Chad, Liberia, and Sierra Leone. Different regions and countries exhibit varying levels of inequality. Disparities were prominent based on educational attainment and place of residence. Higher level of inequality was generally observed among individuals with higher education and those residing in urban areas. Inequality in ANC coverage was also observed by economic status, subnational region, and other factors in Nigeria, Chad, Liberia, and Sierra Leone. ANC coverage is generally higher among the richest quintile subgroup, indicating inequality. Nigeria and Chad show the highest levels of inequality in ANC coverage across multiple measures. Sierra Leone displays some variation with higher coverage among the poorest quintile subgroup.

Conclusion and recommendation

Inequalities in ANC coverage exist across age groups and survey years in Nigeria, Chad, Liberia, and Sierra Leone. Disparities are prominent based on education, residence, and economic status. Efforts should focus on improving access for vulnerable groups, enhancing education and awareness, strengthening healthcare infrastructure, and addressing economic disparities.
Worlds apart? Investigating acceptance and usage demands of carbon-based cosmetics and clothing across European countries
Authors: Wilkowska Wiktoria , Haverkämper Imke Tabea , Ziefle Martina
Published: May 2024

Background

Global warming and the increasing risk of natural disasters force us all to act. As the reduction of carbon dioxide (CO2) emissions has been proven effective but insufficient on its own, Carbon Capture and Utilization (CCU) technologies emerged to fill the gap. Using CCU technologies, CO2 is captured and further processed into valuable products instead of being emitted into the atmosphere.

Method

This study investigates the prevailing public perception of such CCU-based products by the example of clothing and cosmetics. We applied the method of conjoint measurement to experimentally examine context-related factors (= attributes) in different usage settings and explored the consumers’ decision profiles for or against the usage of CCU-based products (cosmetics and clothing). Conjoint measurements were realized as an online experiment, addressing acceptance patterns and preferences in four European countries (Germany, Norway, Spain, and Poland). In addition, we assessed general attitudes and affective assessments of the CCU products. A total of N = 828 participants took part in the study, and the international subsamples were comparable.

Results

Results revealed that health compatibility is the main adoption-driving factor in the decisions for or against the use of the products. Still, attributes like the environmental impact, product quality, and information flow play an important role as well, even though to a lesser extent. Participants from different countries significantly differ in their cognitive and affective evaluations of acceptance-related attributes.

Conclusions

The outcome provides insights into differences in Pan-European comparison and helps to understand the public motives and country-specific terms of use for CCU-based products, effectively establishing recommendations for policy and governance.
A study of spatial cognition in the rural heritage based on VR 3D eye-tracking experiments
Authors: Zhang Han , Andrade Bruno , Wang Xiaoqiong , Aburabee Ibrahim , Yuan Sinan
Published: May 2024

Traditional Chinese villages act as the essential carriers of China’s rural heritage. Such villages are considered to retain living practices of intangible heritage through know-how, artistic and folk customs, as well as a well-preserved architectural appearance. However, their conservation is at stake due to degradation, abandonment, and urbanization. Spatial cognition is one way of bringing people to the matter of what is important to conserve (attributes) and why they are important (values). This is done by analysing how people perceive and value rural heritage. Traditional methods of gathering spatial cognition data, such as laborious fieldwork or subjective qualitative analyses, often fall short of providing a holistic representation of real-world experiences. This article presents an innovative method for analysing cognitive features in traditional village spaces using an immersive virtual reality equipped with an eye-tracking system. We selected Cheng and Jitou, two traditional Chinese villages, as our case studies. In two virtual reality environments, we captured accurate 3D cognitive data, including participants’ locomotion, gaze point, and sightline. The results indicate that the accessibility of village roads affects the distribution of people’s locomotion, which in turn affects the distribution of people’s areas of interest; the changes in the rhythm of the sightline scale reflect the rhythm of spatial changes in the villages. By broadening the understanding of spatial cognition in traditional Chinese villages related to people’s values, this paper sheds light on an alternative approach to assess the cultural significance of such villages for higher conservation and sustainability.
Assessing the current landscape of AI and sustainability literature: identifying key trends, addressing gaps and challenges
Authors: Tripathi Shailesh , Bachmann Nadine , Brunner Manuel , Rizk Ziad , Jodlbauer Herbert
Published: May 2024

The United Nations’ 17 Sustainable Development Goals stress the importance of global and local efforts to address inequalities and implement sustainability. Addressing complex, interconnected sustainability challenges requires a systematic, interdisciplinary approach, where technology, AI, and data-driven methods offer potential solutions for optimizing resources, integrating different aspects of sustainability, and informed decision-making. Sustainability research surrounds various local, regional, and global challenges, emphasizing the need to identify emerging areas and gaps where AI and data-driven models play a crucial role. The study performs a comprehensive literature survey and scientometric and semantic analyses, categorizes data-driven methods for sustainability problems, and discusses the sustainable use of AI and big data. The outcomes of the analyses highlight the importance of collaborative and inclusive research that bridges regional differences, the interconnection of AI, technology, and sustainability topics, and the major research themes related to sustainability. It further emphasizes the significance of developing hybrid approaches combining AI, data-driven techniques, and expert knowledge for multi-level, multi-dimensional decision-making. Furthermore, the study recognizes the necessity of addressing ethical concerns and ensuring the sustainable use of AI and big data in sustainability research.
RETRACTED ARTICLE: Microwave-ultrasonic
assisted extraction of lignin to synthesize new nano micellar organometallic surfactants
for refining oily wastewater
Authors: Alhalafi M. H. , Rizk S. A. , Al-Malki E. S. , Algohary A. M.
Published: May 2024

In this work, a beneficial approach for efficient depolymerization of
lignin and controllable product distribution is provided. Lignin, an abundant aromatic
biopolymer, has the potential to produce various biofuels and chemical adsorption agents
and is expected to benefit the future circular economy. Microwave-ultrasonic (MW/US)
assisted efficient depolymerization of lignin affords some aromatic materials used in
manufacturing the starting material to be investigated. Some nano organometallic
surfactants (NOMS) based on Ni2+,
Cu2+, Co2+,
Fe3+, and Mn2+ besides
2-hydroxynaphth-sulphanilamide are synthesized to enhance oil recovery (EOR). In this
work, the assessment of the NOMS’s efficiency was improving the heavy oil recovery via
the study of the dynamic interfacial tension (IFT), contact angle, and chemical flooding
scenarios. The NOMS-Ni2+ exhibited the maximum reduction of
viscosity and yield values. Dropping the viscosity to 819.9, 659.89, and 499.9 Pa s from
blank crude oil viscosity of 9978.8, 8005.6, and 5008.6 Pa s respectively at
temperatures of 40, 60, and 80 °C was investigated. The reduction of
τB values was obtained also by
OMS-Ni2+. The minimum IFT was recorded against the
Ni2+ derivatives (0.1 × 10–1 mN
m−1). The complete wettability alteration was achieved
with the NOMS-Ni2+ surfactant (ɵ $$\cong 6.01).$$

≅
6.01
)
.

The flooding test has been steered in 3 sets using the sand-packed
model as a porous media at surfactant concentrations (1, 1.5, 2 and 2.5%) at 50 °C and
499 psi as injection pressure. The best value (ORs) formed for
NOMS-Ni2+ were 62, 81, 85.2, and 89% respectively as
compared with other NOMS-M2+ at the same concentrations. The
mechanism of alternating wettability was described in the text. The rheology of the used
heavy crude oil was investigated under temperatures of 40, 60, and 80 °C.

Graphical Abstract
Prognostic potentials of AI in ophthalmology: systemic disease forecasting via retinal imaging
Authors: Tan Yong Yu , Kang Hyun Goo , Lee Chan Joo , Kim Sung Soo , Park Sungha , Thakur Sahil , Da Soh Zhi , Cho Yunnie , Peng Qingsheng , Lee Kwanghyun , Tham Yih-Chung , Rim Tyler Hyungtaek , Cheng Ching-yu
Published: May 2024

Background

Artificial intelligence (AI) that utilizes deep learning (DL) has potential for systemic disease prediction using retinal imaging. The retina’s unique features enable non-invasive visualization of the central nervous system and microvascular circulation, aiding early detection and personalized treatment plans for personalized care. This review explores the value of retinal assessment, AI-based retinal biomarkers, and the importance of longitudinal prediction models in personalized care.

Main text

This narrative review extensively surveys the literature for relevant studies in PubMed and Google Scholar, investigating the application of AI-based retina biomarkers in predicting systemic diseases using retinal fundus photography. The study settings, sample sizes, utilized AI models and corresponding results were extracted and analysed.

This review highlights the substantial potential of AI-based retinal biomarkers in predicting neurodegenerative, cardiovascular, and chronic kidney diseases. Notably, DL algorithms have demonstrated effectiveness in identifying retinal image features associated with cognitive decline, dementia, Parkinson’s disease, and cardiovascular risk factors. Furthermore, longitudinal prediction models leveraging retinal images have shown potential in continuous disease risk assessment and early detection. AI-based retinal biomarkers are non-invasive, accurate, and efficient for disease forecasting and personalized care.

Conclusion

AI-based retinal imaging hold promise in transforming primary care and systemic disease management. Together, the retina’s unique features and the power of AI enable early detection, risk stratification, and help revolutionizing disease management plans. However, to fully realize the potential of AI in this domain, further research and validation in real-world settings are essential.
Association between systemic lupus erythematosus and osteoporosis: a mendelian randomization analysis
Authors: Xu Danfeng , Wu Bing
Published: May 2024

Background

Systemic Lupus Erythematosus (SLE) and Osteoporosis are two prevalent medical conditions. Previous studies have suggested a possible correlation between SLE and osteoporosis, though the underpinning causal relationship remains largely unknown. The current study aimed to elucidate the causal association between SLE and osteoporosis by employing a Mendelian randomization (MR) approach.

Methods

We performed two-sample MR analysis using the inverse variance-weighted (IVW), weighted median, and MR-Egger methods on publicly available summary statistics datasets using a SLE genome-wide association study (GWAS) as an exposure and osteoporosis GWASs in people with East Asia ancestry as outcomes. The pleiotropy and heterogeneity were examined using a variety of techniques, including the MR-Egger intercept, the MR-PRESSO approach, and the Cochran’s Q test.

Results

We selected 26 single-nucleotide polymorphisms from a SLE GWAS as instrumental variables for osteoporosis. The IVW (p < 0.05) method results support a potential association between SLE and osteoporosis. MR-Egger intercept (p = 0.82) and MR-PRESSO global test (p = 0.80) did not suggest evidence of horizontal or directional pleiotropy. Cochran’s Q test (p = 0.78) showed that there was no heterogeneity between IVs.

Conclusion

The results of MR analysis indicated that SLE is likely associated with an increased risk of osteoporosis incidence. Our findings highlight the need for increased awareness the potential risk of osteoporosis among SLE patients.
Physical activity moderates the association between school start time and sleep duration in a cross-sectional national sample of adolescents
Authors: Farley Zachary S. , Ward Mandilyn , Giuliani Nicole R. , Budd Elizabeth L.
Published: May 2024

Background

Adolescent insufficient sleep is an endemic issue that may result in compromised functioning throughout the course of the day and is associated with increased risk for a variety of adverse outcomes. Early school start time (SST) has been consistently found to be detrimental to adolescents’ sleep achievement on school nights. However, there are logistical barriers to changing SST. Evidence supports daily engagement in moderate-to-vigorous intensity physical activity (MVPA) to enhance adolescents’ nightly sleep achievement. However, the role of MVPA in the association between SST and sleep duration is unknown. This study examines the potential moderating effect of MVPA in the association between SST and sleep duration on a typical school day among adolescents.

Methods

This study examined data (collected in April and October 2014) from a national sample of 1132 adolescents (mage = 14.5 years) living in the United States from the Family Life, Activity, Sun, Health, and Eating study, a cross-sectional, internet-based survey. First, three linear regressions were computed to examine bivariate associations between SST, MVPA, and sleep duration while controlling for participant sex, race and ethnicity, household income, school level, and the presence of a TV in the bedroom. Next, a three-step multiple regression was computed with sleep duration as the dependent variable, and the final step included an interaction term between SST and MVPA.

Results

Later SST (b1 = 0.41, p < 0.001) and increased MVPA (b1 = 0.39, p < 0.001) were both associated with increased sleep duration, while SST and MVPA were not significantly associated. In the final multiple regression model, which included the interaction term, school day MVPA moderated the positive association between SST and school night sleep duration (b1 = − 3.7, p < 0.05), such that the greater the MVPA on a typical school day, the weaker the positive association between early SST and sleep duration. In post-hoc analysis, the interaction effect was only significant for females and not males.

Conclusions

The significant buffering effect of MVPA on the association between SST and sleep duration suggests that in the absence of SST changes, promoting MVPA among adolescents may be a promising strategy to mitigate insufficient sleep among US adolescents.
Assisted death for prisoners and forensic patients: complexity and controversy illustrated by four recent cases
Authors: Jones Roland M. , Simpson Alexander I. F.
Published: May 2024

Medical assistance in dying (MAiD) (which includes euthanasia and assisted suicide) is available in an increasing number of countries. In Belgium, The Netherlands and Switzerland (and was due to be implemented in Canada from 2024) eligibility includes mental suffering in the absence of any physical disorder. There are particular ethical and legal issues when considering MAiD for those involuntarily detained in prisons and hospitals. We describe four recent cases that illustrate these complexities, and highlight issues of equivalence of healthcare and self-determination against concerns about the criteria for determining eligibility of those with non-terminal conditions as well as the objections raised by victims and families and the demands for justice.
Association Between Visceral Obesity Index and Diabetes: A Systematic Review and Meta-analysis
Authors: Deng Ruixue , Chen Weijie , Zhang Zepeng , Zhang Jingzhou , Wang Ying , Sun Baichuan , Yin Kai , Cao Jingsi , Fan Xuechun , Zhang Yuan , Liu Huan , Fang Jinxu , Song Jiamei , Yu Bin , Mi Jia , Li Xiangyan
Published: May 2024

Content

The correlation between visceral obesity index (VAI) and diabetes and accuracy of early prediction of diabetes are still controversial.

Objective

This study aims to review the relationship between high level of VAI and diabetes and early predictive value of diabetes.

Data Sources

The databases of PubMed, Cochrane, Embase, and Web of Science were searched until October 17, 2023.

Study Selection

After adjusting for confounding factors, the original study on the association between VAI and diabetes was analyzed.

Data Extraction

We extracted odds ratio (OR) between VAI and diabetes management after controlling for mixed factors, and the sensitivity, specificity, and diagnostic 4-grid table for early prediction of diabetes.

Data Synthesis

Fifty-three studies comprising 595 946 participants were included. The findings of the meta-analysis elucidated that in cohort studies, a high VAI significantly increased the risk of diabetes mellitus in males (OR = 2.83 [95% CI, 2.30-3.49]) and females (OR = 3.32 [95% CI, 2.48-4.45]). The receiver operating characteristic, sensitivity, and specificity of VAI for early prediction of diabetes in males were 0.64 (95% CI, .62–.66), 0.57 (95% CI, .53–.61), and 0.65 (95% CI, .61–.69), respectively, and 0.67 (95% CI, .65–.69), 0.66 (95% CI, .60–.71), and 0.61 (95% CI, .57–.66) in females, respectively.

Conclusion

VAI is an independent predictor of the risk of diabetes, yet its predictive accuracy remains limited. In future studies, determine whether VAI can be used in conjunction with other related indicators to early predict the risk of diabetes, to enhance the accuracy of prediction of the risk of diabetes.
Profound Coronary Vasospasm Associated with Intraoperative Ketamine Administration: A Case Report
Authors: Perez Richard K. , Lighthall Geoffrey
Published: May 2024

We report a case of a 62-year-old woman with a decade-long history of atypical chest pain resulting in a largely negative cardiac workup, who developed significant angiographically demonstrated coronary vasospasm thought to be due to a small dose of intravenous ketamine. In patients with a history of atypical chest pain despite a reassuring cardiac evaluation, providers should carefully consider medications that may precipitate coronary vasospasm and be prepared to treat it accordingly.
Every Picture Tells A Story: Managing Exertional Heatstroke with Rotating Ice Water Towels
Authors: Roberts William O.
Published: May 2024

A 23-year-old woman completing her first marathon collapsed near the finish line at 4 hours 6 min with a rectal temperature of 41.8°C. She was in good health before the race with no recent illness, had completed a full training program, and was taking no medications or supplements. On the initial exam, she was unconscious with a response to painful stimulus, spontaneous breathing, rapid pulse, eyes closed, fully dilated pupils, poor muscle tone, and pale skin that was warm to touch. The medical team initiated whole-body cooling using rapidly rotating ice water towels and ice packs placed in the neck, axilla, and groin. She developed echolalia during active cooling. About 20 minutes into the cooling procedure, she “woke up,” was able to answer questions coherently, and her pupils were normal size and reactive. She was discharged home with instructions to follow-up in 2 d for evaluation and blood chemistry testing.
Philanthropic Cause Prioritization
Authors: Oehlsen Emily
Published: May 2024

Many foundations decide how much and where to give based on their founders' personal precommitments to specific issues, geographies, and/or institutions. If a grantmaking organization instead wanted to select problems based on a general measure of impact per dollar spent, how should it approach this goal? What tools could it use to identify promising cause areas (climate change, education, or health, for example) or to compare grants that achieve different results? This paper focuses on an approach followed by the grantmaking organization Open Philanthropy for its “Global Health and Wellbeing” portfolio, with an emphasis on two key frameworks: equalizing marginal philanthropic returns, as well as importance, neglectedness, and tractability. It describes measurement and comparability under the first framework, and then applies the second framework to the example of reducing exposure to lead. It concludes by considering critiques and areas for improvement.
W poszukiwaniu biblijnego Gilgal
Authors: Pikor Wojciech
Published: May 2024

Artykuł stanowi krytyczną recenzję monografii Dariusza Dziadosza Gilgal. Biblia – Archeologia – Teologia. Studium historyczno-krytyczne deuteronomi(sty)cznych tradycji o podboju Kanaanu. Celem monografii Dziadosza o Gilgal jest analiza historyczno-krytyczna deuteronomicznych i deuteronomistycznych tradycji o podboju Kannanu, w którym kluczową rolę odegrało Gilgal leżące blisko Jerycha. Badania Dziadosza mają charakter interdyscyplinarny. Analizuje on dane etnograficzne, topograficzne i archeologiczne o Gilgal, zaś w analizie tekstów biblijnych łączy podejście synchroniczne z diachronicznym. To pierwsze w literaturze polskiej tak kompletne i całościowe studium historii Gilgal w okresie przedmonarchicznym. Stanowi ono zachętę do kontynuowania badań nad biblijnym Gilgal w drugiej części historii deuteronomistycznej (1 Sm – 2 Krl) oraz w księgach prorockich.