bluuebunny/crossref_metadata_2025 huggingface dataset:
Unveiling the Sub-10 GHz Performance of SMA Connectors: A Comparative Analysis
Authors: Vasjanov Aleksandr , Barzdenas Vaidotas , Jurgo Marijan , Gursnys Darius
Published: July 2024

This research review article provides a detailed examination of SMA (SubMiniature version A) connectors, which are integral components in high-frequency electronic systems. Through extensive S-parameter and time-domain reflectometry (TDR) measurements conducted on various SMA connector constructions, this study aims to evaluate the performance and impact of SMA connectors on signal integrity. Results reveal insights into the comparative performance of different SMA connector types mounted on PCB land pads, highlighting their strengths and limitations. Additionally, this paper explores the application of reference plane cut-outs for discontinuity impedance compensation, aiming to enhance the frequency response of SMA connectors. By linking measured performance parameters with relative market prices, this study offers valuable insights into the economic viability of different SMA connector types. The best and worst performing SMA connector measurements reveal an S11 < −10 dB bandwidth of more than 8 GHz and 1.5 GHz and a transition impedance of 46.5 Ω and 21 Ω, respectively. Overall, this research contributes to advancing the understanding and selection of SMA connectors for RF applications in telecommunications, aerospace, medical devices, and beyond.
Modelling and Forecasting Crude Oil Prices Using Trend Analysis in a Binary-Temporal Representation
Authors: Stasiak Michał Dominik , Staszak Żaneta
Published: July 2024

The oil market is one of the most important markets for the global economy. Often, oil prices influence the financial results of whole countries and sectors. Therefore, the modeling and prediction of crude oil prices are of high importance. Most up-to-date publications have used daily closing rates in crude oil price modeling, not considering the variability in prices during the day. The application of this kind of price representation leads to a loss of information about the range of price changes during the day, which influences the accuracy of the models and makes them useless in short-term course predictions. In this paper, we introduce the concept of a new state model in a binary-temporal representation, which uses trend analysis, which is one of the main methods used in the prediction of the direction of future changes in the course trajectory. The model described in this paper stands as the first tool that allows for predicting course changes in a given range. The presented work also summarizes the research results of modeling crude oil prices from the last six years, which prove the effectiveness of the mentioned modeling method.
Addressing Data Scarcity in Solar Energy Prediction with Machine Learning and Augmentation Techniques
Authors: Gevorgian Aleksandr , Pernigotto Giovanni , Gasparella Andrea
Published: July 2024

The accurate prediction of global horizontal irradiance (GHI) is crucial for optimizing solar power generation systems, particularly in mountainous areas with complex topography and unique microclimates. These regions face significant challenges due to limited reliable data and the dynamic nature of local weather conditions, which complicate accurate GHI measurement. The scarcity of precise data impedes the development of reliable solar energy prediction models, impacting both economic and environmental outcomes. To address these data scarcity challenges in solar energy prediction, this paper focuses on various locations in Europe and Asia Minor, predominantly in mountainous regions. Advanced machine learning techniques, including random forest (RF) and extreme gradient boosting (XGBoost) regressors, are employed to effectively predict GHI. Additionally, optimizing training data distribution based on cloud opacity values and integrating synthetic data significantly enhance predictive accuracy, with R2 scores ranging from 0.91 to 0.97 across multiple locations. Furthermore, substantial reductions in root mean square error (RMSE), mean absolute error (MAE), and mean bias error (MBE) underscore the improved reliability of the predictions. Future research should refine synthetic data generation, optimize additional meteorological and environmental parameter integration, extend methodology to new regions, and test for predicting global tilted irradiance (GTI). The studies should expand training data considerations beyond cloud opacity, incorporating sky cover and sunshine duration to enhance prediction accuracy and reliability.
Human and Murine Cell Lines for Adrenocortical Carcinoma and Pheochromocytoma
Authors: Luca Edlira , Abate Andrea , Wang Katharina , Bornstein Stefan , Sigala Sandra , Beuschlein Felix , Nölting Svenja , Hantel Constanze
Published: July 2024

Adrenocortical carcinoma (ACC) and pheochromocytoma (PCC) are malignancies originating from distinct layers of the adrenal gland. ACCs arise from the adrenal cortex, are often detected at advanced stages and are associated with poor prognosis. PCCs are mostly benign, arise from the adrenal medulla and have a variable prognosis, with 10% of PCCs resulting in metastasis. Genetic background strongly influences metastasis of PCCs, and no reliable biomarkers that predict metastatic behavior exist to date. Current therapeutic strategies for both ACCs and PCCs are overall limited. Thus, novel preclinical models and drug screening approaches need to be established to aid in the identification of more promising drugs and treatment schemes. In this review, we summarize the currently available human and murine cell lines for both tumor entities.
Empowering Remote Living: Optimizing Hybrid Renewable Energy Systems in Mexico
Authors: León Gómez Juan Carlos , Aguayo Alquicira Jesus , De León Aldaco Susana Estefany , Sánchez Vargas Oscar , Gómez Díaz Kenia Yadira
Published: July 2024

The developing environmental consequences of excessive dependence on fossil fuels have pushed many countries to invest in clean and renewable energy sources. Mexico is a country that, due to its geographic and climatic diversity, can take advantage of this potential in renewable energy generation and reduce its dependence on fossil fuels while developing strategies to improve its energy system. This study investigated the feasibility of the autonomous use of two hybrid renewable energy systems and a photovoltaic system to power homes in a remote location. With the help of HOMER Pro Version 3.14.5 software, a model was made to evaluate the operation of three systems for one year, and the demand was predicted according to a given scenario. In addition, the optimal configuration of the components of each system was determined. The results showed that the simultaneous use of solar systems with a converter and a backup system consisting of a diesel generator and batteries would be the most viable and reliable option for generating renewable energy at the selected location, offering electricity with a renewable fraction of more than 80%.
Unveiling the Impact of Lactic Acid Bacteria on Blood Lipid Regulation for Cardiovascular Health
Authors: Yilmaz Birsen , Arslan Neslihan , Şahin Teslime Özge , Ağadündüz Duygu , Ozogul Fatih , Rocha João Miguel F.
Published: July 2024

Lactic acid bacteria (LAB) are a group of microorganisms which are beneficial and well-characterized with respect to the flavor and texture of food products via fermentation. The accumulated literature has suggested that dietary intake of fermented foods rich in LAB is related to different health-promoting benefits; however, in recent years, emerging evidence suggests a contribution of LAB to blood lipid regulation and cardiovascular health via certain mechanisms. Different potential mechanisms for the lipid regulatory effects of LAB may include the interaction of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and bile salt hydrolase activity and bile salt metabolism; gut microbiome modulation; and regulation of mRNA expression of genes related to fat metabolism in animal models and human studies. This review comprehensively aims to answer whether/how LAB influence blood lipids in both animal models and human studies while also uncovering the underlying mechanisms linking LAB to lipid metabolism.
Characterization of Several Pellets from Agroforestry Residues: A Comparative Analysis of Physical and Energy Efficiency
Authors: Papandrea Salvatore Francesco , Palma Adriano , Carnevale Monica , Paris Enrico , Vincenti Beatrice , Gallucci Francesco , Proto Andrea Rosario
Published: July 2024

The use of agroforestry biomass provides several advantages, both from an environmental point of view, in terms of the mitigation of global warming, and in terms of a circular economy for agricultural or agroforestry companies that reuse pruning residues as a source of energy. However, even if the use of energy pellets resulting from the pruning residues of various agroforestry species has excellent potential for the valorization of agricultural by-products, the physicochemical characteristics of these pellets have been scarcely studied by the scientific community. In this context, this study aims to assess the valorization potential of various lignocellulosic material residues produced during agroforestry activities. The objectives of the study include evaluating the chemical and physical characteristics of pellets produced with different mixtures of agroforestry biomass (olive, citrus, black locust, poplar, paulownia, etc.) in order to determine the optimal pellet blend from an energy and physicochemical perspective. The results of this study demonstrate that this comprehensive analysis provides valuable information on the optimization of biomass mixtures for better energy valorization, addressing both compositional and combustion-related challenges. In fact, it is observed that the addition of citrus and olive biomass to the various mixtures increases their energy potential. Furthermore, all of the pellets analyzed are found to possess an adequate and useful durability index (PDI) for their handling during storage and transport operations. This study demonstrates that olive and citrus pruning residues can be used to improve biomasses that have poor suitability in energetic, physical, and chemical terms. Further studies could be useful to understand which specific interaction mechanisms have an influence on emissions in order to optimize mixtures using different biomass sources for sustainable energy production.
Investigating the Dietary Impact on Trans-Vaccenic Acid (Trans-C18:1 n-7) and Other Beneficial Fatty Acids in Breast Milk and Infant Formulas
Authors: Sanjulian Laura , Lamas Alexandre , Barreiro Rocío , Martínez Ismael , García-Alonso Leopoldo , Cepeda Alberto , Fente Cristina , Regal Patricia
Published: July 2024

Maternal diet plays a significant role in the fatty acid composition of breast milk. Dietary products such as milk and meat are the primary sources of natural TFAs for humans. These peculiar fatty acids hold nutritional significance as they not only lack the detrimental effects of industrially produced trans fats on the endothelium characteristic, but they also exhibit anti-inflammatory properties. The relationship between the presence of eight fatty acids in breast milk (including natural TFAs trans-vaccenic and conjugated linoleic acid) and the maternal diet has been explored, and their abundance has been compared to that of infant formulas. Two cohorts of lactating women, originating from a Spanish region, participated in this study; they adhered to the Southern European Atlantic diet or the Atlantic diet. While the consumption of conventional meat or dairy products does not seem to increase the abundance of TFAs in breast milk, trans-vaccenic and oleic acid are among the most distinctive features of breast milk fat in mothers consuming naturally improved dairy products with an improved fatty acid profile. The most significant differences between natural breastfeeding and formula feeding lie in natural TFAs, since formulas are notably deficient in natural TFAs while being overfortified in alpha-linolenic acid in comparison to breast milk. We suggest an improvement in the formulation of these products through using cow’s milk with an optimal fatty acid profile that better mimics the fatty acid composition found in human milk.
Fatty Acids Profile and Consumers’ Preferences of Pecorino Cheese Manufactured from Milk of Sheep Supplemented with Flaxseed and Ascophyllum nodosum
Authors: Santillo Antonella , Ciliberti Maria Giovanna , Caroprese Mariangela , Sevi Agostino , Albenzio Marzia
Published: July 2024

The impact of flaxseed and Ascophyllum nodosum supplementation in ewes during the summer season on the fatty acid and sensory profile and consumer preference for cheese was evaluated. Comisana ewes (n = 32) were divided into four groups: a control (CON) group fed (30 days) with pelleted concentrate, a flaxseed (FS) group fed with whole flaxseed supplementation (250 g/ewe per day), an A. nodosum (AN) group fed with 5% of A. nodosum (into 1 kg/ewe of pelleted concentrate), and an FS + AN group fed with a combination of algae and flaxseed. Pecorino cheeses were analysed after 1 day (curd) and after 45 days (cheese) of ripening. Curd from the FS and FS + AN groups registered higher contents of MUFA, n-3, and n-3/n-6, and lower levels of atherogenic and thrombogenic indexes than curd from the CON and AN groups, as well as a higher content of C18:3n-3, C18:2t9t12, and CLA9c11t, and n-3 and n-3/n-6 fatty acids. Consumers attributed the lowest scores for appearance attributes to AN Pecorino cheese; while Pecorino cheese from FS and FS + AN was judged to have a high-strength flavour attribute and a low rancid, mouldy, and piquant flavour, in comparison with cheese from AN. Flaxseed supplementation could be an effective strategy to improve the nutritional quality of the lipid fraction of cheese without having a detrimental impact on its sensory attributes, especially during the summer season.
Interactions and Behaviors of Pedestrians with Autonomous Vehicles: A Synthesis
Authors: Rezwana Saki , Lownes Nicholas
Published: July 2024

Integrating autonomous vehicles (AVs) into public roads presents profound implications for pedestrian safety and the broader acceptance of this emerging technology. This work examines the complex interactions between AVs and pedestrians, a dynamic influenced by the variability of pedestrian behaviors and the absence of traditional communication mechanisms, such as eye contact and gestures, commonly relied upon in human-driven scenarios. Given the nascent stage of AV deployment, this research addresses the challenges of evaluating AV−pedestrian interactions amid safety concerns and technological limitations. We review and synthesize global research on pedestrian behavior in the context of AV technology to track changes in pedestrians’ acceptance over time and identify the factors driving these shifts. Additionally, this review incorporates insights from transportation authorities to highlight potential safety issues and the need for innovative communication strategies that ensure safe interactions between pedestrians and AVs. By analyzing these factors, the research aims to contribute to the development of guidelines and communication protocols that enhance pedestrian safety and facilitate the integration of AVs into urban environments.
Determinants of the Willingness to Use Autonomous Mobility as a Service in Germany
Authors: Glimm Frieder , Fabus Michal
Published: July 2024

Fully autonomous vehicles, once legally and technically feasible and widely available, have numerous advantages compared to human-driven vehicles, from greater availability and shorter travel times to lower negative environmental emissions and fewer accidents. This, combined with a usage-based form of payment, can massively increase the usage rate of vehicles without the need for high initial investments. This study explores the determinants affecting the willingness to adopt Autonomous Mobility as a Service (AMaaS) in Germany. Utilizing a mobile cross-sectional survey via Pollfish, 400 complete responses of German speakers aged 18 years or older in Germany were collected to assess influential factors. The survey data were analyzed using binary logistic regression analysis. Age, possession of a driving license, and the quality of public transport were identified as significant predictors. Younger people and driving license holders showed a higher willingness to use AMaaS, while low-quality public transport reduced their willingness to use it. This study concludes that targeted strategies for AMaaS implementation should consider these key demographic and infrastructural factors to maximize market penetration and acceptance in Germany.
“The Indians Complain, and with Good Cause”: Allotting Standing Rock—U.S. Policy Meets a Tribe’s Assertion of Rights
Authors: Egbert Stephen L. , Meisel Joshua J.
Published: July 2024

Land allotment was embraced by the U.S. Government in the late 1800s and early 1900s as part of a solution to the “Indian problem”, the goal of which was assimilation into the Euro-American cultural and economic system. As a progressivist program, it was imposed with enthusiasm and confidence, dividing reservations into rectangular land parcels (allotments) in the belief that the allotment recipients would become yeoman farmers of the Jeffersonian mold. Tribes were unable to thwart the imposition of allotment, despite their best efforts, and its devastating long-term effects are now well known. Much less is understood, however, about the efforts of various tribes, sometimes successful and sometimes not, to obtain modifications to the terms of allotment imposed on them. We describe how the people of the Standing Rock Reservation in North and South Dakota successfully advocated for modifications which worked to their significant advantage. We draw heavily from the outgoing correspondence and allotment records of the Special Allotting Agent, Carl Gunderson, along with contemporaneous records of legislative proceedings and other documents. The successful efforts of the people of Standing Rock resulted not only in equitable access to scarce timber, but in allotments to numerous individuals who otherwise would have been ineligible. The net impact was the additional allotment of nearly 400,000 acres (160,000 ha) to over 1800 individuals who otherwise would have received nothing.
Urban Planning with Rational Green Infrastructure Placement Using a Critical Area Detection Method
Authors: Herath Herath Mudiyanselage Malhamige Sonali Dinesha , Fujino Takeshi , Senavirathna Mudalige Don Hiranya Jayasanka
Published: July 2024

In an era of intense urban development and climate extremes, green infrastructure (GI) has become crucial for creating sustainable, livable, and resilient cities. However, the efficacy of GI is frequently undermined by haphazard implementation and resource misallocation that disregards appropriate spatial scales. This study develops a geographic information system (GIS)-based critical area detection model (CADM) to identify priority areas for the strategic placement of GI, incorporating four main indices—spatial form, green cover, gray cover, and land use change—and utilizing the digital elevation model (DEM), normalized difference vegetation index (NDVI), urban density index (UDI), and up-to-date land use data. By employing the developed method, the study successfully locates priority zones for GI implementation in Saitama City, Japan, effectively pinpointing areas that require immediate attention. This approach not only guarantees efficient resource allocation and maximizes the multifunctional benefits of GI but also highlights the importance of a flexible, all-encompassing GI network to address urbanization and environmental challenges. The findings offer policymakers a powerful tool with which to optimize GI placement, enhancing urban resilience and supporting sustainable development.
Evaluation of a Virtual Tai Chi Program for Older Veterans at Risk of Loneliness or Physical Deconditioning: A Quality Improvement Project
Authors: Dawson Bonnie D. , Keller Hallie E. , Sawyer Linda M. , Gorman Shannon , Sabangan Jerome A. , McPartlin Adam , Payne Sarah , Brown Karl J. , Li Gail , Sullivan Dennis H.
Published: July 2024

This Quality Improvement project evaluated the implementation of a virtual Tai Chi program for older Veterans (OVs) at risk of loneliness and/or physical deconditioning. A 12-week Tai Chi course was conducted virtually at three Veterans Affairs sites using VA Video Connect (VVC). Changes in physical function based on the 30-Second Chair Stand (30CST) and loneliness based on the De Jong Gierveld Loneliness Scale (DJGS) were measured, as were the OVs’ satisfaction and adherence. Of 109 OVs who enrolled, 74 completed the program with a mean attendance rate of 84%. Completers demonstrated a statistically significant improvement in the 30CST, and those who were moderately or severely lonely at baseline saw a statistically significant improvement in the DJGS. Course evaluations were generally very positive. Results suggest that a virtual Tai Chi program is an effective and very satisfying intervention for OVs at risk of loneliness or physical deconditioning.
Risk of Hemorrhoidal Bleeding in Patients Treated with Direct Oral Anticoagulants (DOACs)
Authors: Petruzziello Carmine , Saviano Angela , Brigida Mattia , Migneco Alessio , Manetti Luca Luigi , Candelli Marcello , Ojetti Veronica
Published: July 2024

(1) Background: Lower gastrointestinal bleeding (LGIB) accounts for 20% of all gastrointestinal bleeds. LGBI originates in the colon, rectum, and anus, mainly in patients who are receiving antiaggregant or anticoagulant treatment. The major causes are diverticular disease, colitis, hemorrhoids, and angiodysplasia. The literature studies underline that Direct Oral Anticoagulants (DOACs) are effective in reducing the risk of thromboembolic events but are associated with a higher risk of lower gastrointestinal bleeding (LGIB), particularly lower hemorrhoid bleeding. (2) Methods: The aim of our review is to revise the risk of hemorrhoid bleeding, pathophysiology, and management in patients taking DOACs in light of the most modern evidence. (3) Conclusions: central to the management of hemorrhoid bleeding in patients receiving DOAC therapy is the consideration of a tailored approach that respects the delicate equilibrium between the need for thromboembolic prophylaxis and the potential for bleeding complications. Cessation of anticoagulation, if clinically feasible, constitutes a fundamental cornerstone in the control of hemorrhage. This pause in therapy aims to mitigate the exacerbation of bleeding risk while offering a window for the implementation of local measures to manage hemorrhoid bleeding.
Integrating the Sufficiency Economy Royal Philosophy and Participatory Action Research Approach to Promote Self-Care for Stroke Prevention in Selected Communities of Southern Thailand
Authors: Sathirapanya Chutarat , Trijun Jamaree , Sathirapanya Pornchai
Published: July 2024

(1) Introduction: Effective control of stroke risk factors can reduce stroke incidence. Motivation for participatory action of community dwellers to practice self-care to modify stroke risk after providing them with knowledge of stroke risk factors is considered useful under a situation of limited healthcare resources. This study aimed to evaluate the outcomes of integrating the sufficiency economy philosophy (SEP), a royal economic philosophy in Thailand, and the participatory action research (PAR) approach on stroke risk factors control among selected communities. (2) Methods: Villagers who had medium to high stroke risk from two provinces with leading stroke incidences in southern Thailand were invited to participate in an eight-month SEP-PAR program conducted in 2019. Group meetings among the study participants, local healthcare providers, the researchers, and relevant stakeholders in the communities were held to co-design a health behaviors program targeting lower waist circumference (WC), body weight (BW), blood pressure (BP), fasting blood sugar, blood lipids, and smoking and alcohol consumption rates. Follow-up physical measurements and blood tests were compared with the baseline results for significant differences by descriptive statistics (p < 0.05) using the R program. (3) Results: Of 126 participants, 75.4% were female. Moderate and high stroke risk levels were found in 58.2% and 19.8%, respectively. Elevated baseline WC, BW, BP, and blood test results were found in 50–80% of the participants. The co-designed health behaviors in this study were dietary control, regular exercise, relieving psychological stress, and stopping smoking and alcohol consumption. Overall, the participants had significant adherence to the co-designed health behaviors. At the end of the program, the follow-up tests showed significant reductions in BW, BP, fasting blood sugar, and lipids, but not in WC. (4) Conclusions: A combined SEP and PAR approach was effective for stroke risk factors control among the community dwellers. Motivation for self-care is a significant strategic outcome expected of this approach. Longer follow-up studies in larger populations are needed.
Sex Disparities in the Direct Cost and Management of Stroke: A Population-Based Retrospective Study
Authors: Lucas-Noll Jorgina , Clua-Espuny José L. , Carles-Lavila Misericòrdia , Solà-Adell Cristina , Roca-Burgueño Íngrid , Panisello-Tafalla Anna , Gavaldà-Espelta Ester , Queralt-Tomas Lluïsa , Lleixà-Fortuño Mar
Published: July 2024

(1) Background: Previous studies have identified disparities in stroke care and outcomes by sex. Therefore, the main objective of this study was to evaluate the average cost of stroke care and the existence of differences in care provision by biological sex. (2) Methods: This observational study adhered to the recommendations of the STROBE statement. The calculation of costs was performed based on the production cost of the service or the rate paid for a set of services, depending on the availability of the corresponding information. (3) Results: A total of 336 patients were included, of which 47.9% were women, with a mean age of 73.3 ± 11.6 years. Women were typically older, had a higher prevalence of hypertension (p = 0.005), lower pre-stroke proportion of mRS 0-2 (p = 0.014), greater stroke severity (p < 0.001), and longer hospital stays (p = 0.017), and more were referred to residential services (p = 0.001) at 90 days. Women also required higher healthcare costs related to cardiovascular risk factors, transient ischemic strokes, institutionalization, and support needs; in contrast, they necessitated lower healthcare costs when undergoing endovascular therapy and receiving rehabilitation services. The unadjusted averaged cost of stroke care was EUR 22,605.66 (CI95% 20,442.8–24,768.4), being higher in women [p = 0.027]. The primary cost concept was hospital treatment (38.8%), followed by the costs associated with dependence and support needs (36.3%). At one year post-stroke, the percentage of women not evaluated for a degree of dependency was lower (p = 0.008). (4) Conclusions: The total unadjusted costs averaged EUR 22,605.66 (CI95% EUR 20,442.8–24,768.4), being higher in women compared to men. The primary cost concept was hospital treatment (38.8%), followed by the costs associated with dependence and support needs (36.3%).
Translation and Validation of Digital Competence Indicators in Greek for Health Professionals: A Cross-Sectional Study
Authors: Karvouniari Alexandra , Karabetsos Dimitrios , Kleisiaris Christos F. , Karavasileiadou Savvato , Baghdadi Nadiah , Kyrarini Virginia-Athanasia , Kasagianni Evangelia , Tsalkitzi Afroditi , Malliarou Maria , Melas Christos
Published: July 2024

Background: it is widely accepted that living in the digital transformation era, the need to develop and update new professional skills and tools in health sectors is crucially important. Therefore, this study aimed to explore the reliability and validity of the Digital Competence Indicators tool in assessing the digital skills of Greek health professionals. Methods: in this cross-sectional study, 494 health professionals, including doctors (175) and registered nurses (319) working in four Greek hospitals were recruited and willingly participated using a convenience-sampling method. The original framework of Digital Competence Indicators was translated from English to Greek based on guidelines for cross-cultural adaptation of questionnaires. The validity of the tool was explored using confirmatory factor analysis (CFA) to verify the fit of the model using inductive techniques. The instrument reliability was confirmed using Cronbach’s alpha (α) and McDonald’s Omega coefficients. Results: the reliability was estimated at 0.826 (Cronbach’s-α) and 0.850 (McDonald’s Omega-ω). The indicators of CFA were all calculated within an ideal range of acceptance. Specifically, the CFA comparative fit index produced the following adjustment indices: x2/df = 1.152 (p = 0.037), CFI = 0.997, Lewis index (TLI) = 0.966, and root mean square error of approximation (RMSEA) = 0.018. Conclusions: The present study demonstrated that the Digital Competence Indicator instrument has high reliability, internal consistency, and construct validity and, therefore, it is suitable for measuring digital skills of health professionals.
Insights into Digital MedicRehApp Maintenance Model for Pulmonary Telerehabilitation: Observational Study
Authors: Vitacca Michele , Paneroni Mara , Saleri Manuela , Beccaluva Chiara Giuseppina
Published: July 2024

Maintenance strategies after center-based pulmonary rehabilitation (CBPR) are currently needed. This study aimed to evaluate the feasibility and effect on the quality of life of a home-based pulmonary rehabilitation (HBPR) program delivered by a digital app. As secondary objectives, the patients’ adherence, symptoms, effort tolerance changes, and safety were evaluated. This was a single-arm prospective observational monocentric study on 30 patients referred for chronic respiratory diseases. The prescription and evaluations of the HBPR programs performed at the pulmonary facility and delivery of structured exercise and counselling by the digital health tool were achieved under the supervision of a respiratory therapist. Digital capabilities included aerobic, strength, and respiratory exercises, which were monitored with a fitness tracker. The engagement rate of the HBPR after the CBPR was 1:10. The EuroQoL VAS score increased from 66.2 ± 16.28 to 75.60 ± 16.07 (p < 0.001), mainly in younger subjects. No patient was lost during the HBPR program. The global adherence session rate was 94%. The Medical Research Council dyspnea scale (MRC), COPD Assessment Test (CAT) score, and six-minute walking test (6MWT) improved from admission into the pulmonary unit to the end of the HBPR program. Between the beginning and end of the CBPR, the CAT score decreased from 14.4 ± 6.39 to 8.50 ± 5.39 (p < 0.001), the MRC decreased from 1.87 ± 0.9 to 1.17 ± 0.83 (p < 0.001), and the 6MWT increased from 451 ± 93 to 473 ± 115 m (p < 0.05). The average Technology Acceptance Model score for usability was high (145 ± 12.1) and no adverse events occurred during the HBPR program. This HBPR model seemed to be feasible and well-accepted by patients, leading to improvements in quality of life, symptoms, and functional capacity.
Combining Ability and Hybrid Breeding in Tunisian Melon (Cucumis melo L.) for Fruit Traits
Authors: Chikh-Rouhou Hela , Kienbaum Lydia , Gharib Amani H. A. M. , Fayos Oreto , Garcés-Claver Ana
Published: July 2024

A half-diallel cross study of seven melon inbred lines was carried out. The seven parents and their 21 F1 hybrids were evaluated for precocity of maturity, average weight per fruit, and fruit quality (fruit size, rind thickness, and soluble solids). The Diallel analysis was investigated for breeding values of these melon genotypes via general and specific combining ability, relationships between general and specific combining ability, and heterosis for the evaluated traits. The analysis of variance of the traits evaluated indicated highly significant differences among genotypes, suggesting the presence of adequate genetic variation for breeding. Additive genetic effects were most important with respect to fruit weight, while genetic dominance and epistasis effects mainly controlled fruit quality traits (fruit size, rind thickness, and TSS). Parent 1 (P1) and parent 3 (P3) had significant positive general combining ability effects for fruit weight. Also, P3 had positive general combining ability effects for fruit length and diameter, and cavity diameter. P3 was found to show maximum significant GCA in the desirable direction for all the traits except for TSS. Evaluation of heterosis (%) revealed that hybrid P1 × P3 can be considered as the best-performing hybrid for average fruit weight, TSS, and precocity, which also exhibited the highest positive and significant SCA effect for these traits. These results suggested that, among the melon genotypes studied, there is the potential to generate superior new varieties in hybrid production.
Fruit Position, Light Exposure and Fruit Surface Temperature Affect Colour Expression in a Dark-Red Apple Cultivar
Authors: Peavey Madeleine , Scalisi Alessio , Islam Muhammad S. , Goodwin Ian
Published: July 2024

This study aimed to evaluate the effects of fruit position, light exposure and fruit surface temperature (FST) on apple fruit colour development and fruit quality at harvest, including sunburn damage severity. This was achieved by undertaking two experiments in a high-density planting of the dark-red apple ANABP 01 in Tatura, Australia. In the 2020–2021 growing season an experiment was conducted to draw relationships between fruit position and fruit quality parameters. Here, sample fruit position and level of light exposure were respectively determined using a static LiDAR system and a portable quantum photosynthetically active radiation (PAR) sensor. At harvest the sample fruit were analysed for percentage red colour coverage, objective colour parameters (L*, a*, b*, hue angle and chroma), sunburn damage, fruit diameter (FD), soluble solids concentration (SSC), flesh firmness (FF) and starch pattern index (SPI). A second experiment was conducted in the 2021–2022 growing season and focused on how fruit shading, light exposure and the removal of ultraviolet (UV) radiation affected the FST, colour development and harvest fruit quality. Five treatments were distributed among sample fruit: fully shaded with aluminium umbrellas, shaded for one month and then exposed to sunlight until harvest, exposed for one month and then shaded until harvest, covered with a longpass UV filter and a control treatment. The development of colour in this dark-red apple cultivar was highly responsive to aspects of fruit position, and the intensity and quality of light exposure. The best-coloured fruit were exposed to higher quantities of PAR, exposed to both PAR and UV radiation simultaneously and located higher in the tree canopy. Fruit that were fully exposed to PAR and achieved better colour development also displayed higher FST and sunburn damage severity.
Cytomegalovirus in Adenoma and Carcinoma Lesions: Detecting Mono-Infection and Co-Infection in Salivary Glands
Authors: Guimarães Ana Carolina Silva , Raposo Vedovi Jéssica Vasques , de Almeida Ribeiro Camilla Rodrigues , Martinelli Katrini Guidolini , Pelajo Machado Marcelo , de Abreu Manso Pedro Paulo , Euzebio Pereira Dias de Oliveira Barbara Cristina , Bergamini Mariana Lobo , de Rosa Catharina Simioni , Tozetto-Mendoza Tania Regina , Fernandes de Souza Ana Carolina Mamana , Martins Marília Trierveiler , Braz-Silva Paulo Henrique , de Paula Vanessa Salete
Published: July 2024

Salivary glands’ neoplasms are hard to diagnose and present a complex etiology. However, several viruses have been detected in these neoplasms, such as HCMV, which can play a role in certain cancers through oncomodulation. The co-infections between HCMV with betaherpesviruses (HHV-6 and HHV-7) and polyomaviruses (JCV and BKV) has been investigated. The aim of the current study is to describe the frequency of HCMV and co-infections in patients presenting neoplastic and non-neoplastic lesions, including in the salivary gland. Multiplex quantitative polymerase chain reaction was used for betaherpesvirus and polyomavirus quantification purposes after DNA extraction. In total, 50.7% of the 67 analyzed samples were mucocele, 40.3% were adenoma pleomorphic, and 8.9% were mucoepidermoid carcinoma. Overall, 20.9% of samples presented triple-infections with HCMV/HHV-6/HHV-7, whereas 9.0% were co-infections with HCMV/HHV-6 and HCMV/HHV-7. The largest number of co-infections was detected in pleomorphic adenoma cases. All samples tested negative for polyomaviruses, such as BKV and JCV. It was possible to conclude that HCMV can be abundant in salivary gland lesions. A high viral load can be useful to help better understand the etiological role played by viruses in these lesions. A lack of JCV and BKV in the samples analyzed herein does not rule out the involvement of these viruses in one or more salivary gland lesion subtypes.
Chemokine CX3CL1 (Fractalkine) Signaling and Diabetic Encephalopathy
Authors: Wątroba Mateusz , Grabowska Anna D. , Szukiewicz Dariusz
Published: July 2024

Diabetes mellitus (DM) is the most common metabolic disease in humans, and its prevalence is increasing worldwide in parallel with the obesity pandemic. A lack of insulin or insulin resistance, and consequently hyperglycemia, leads to many systemic disorders, among which diabetic encephalopathy (DE) is a long-term complication of the central nervous system (CNS), characterized by cognitive impairment and motor dysfunctions. The role of oxidative stress and neuroinflammation in the pathomechanism of DE has been proven. Fractalkine (CX3CL1) has unique properties as an adhesion molecule and chemoattractant, and by acting on its only receptor, CX3CR1, it regulates the activity of microglia in physiological states and neuroinflammation. Depending on the clinical context, CX3CL1-CX3CR1 signaling may have neuroprotective effects by inhibiting the inflammatory process in microglia or, conversely, maintaining/intensifying inflammation and neurotoxicity. This review discusses the evidence supporting that the CX3CL1-CX3CR1 pair is neuroprotective and other evidence that it is neurotoxic. Therefore, interrupting the vicious cycle within neuron–microglia interactions by promoting neuroprotective effects or inhibiting the neurotoxic effects of the CX3CL1-CX3CR1 signaling axis may be a therapeutic goal in DE by limiting the inflammatory response. However, the optimal approach to prevent DE is simply tight glycemic control, because the elimination of dysglycemic states in the CNS abolishes the fundamental mechanisms that induce this vicious cycle.
A Framework for Antecedents to Health Information Systems Uptake by Healthcare Professionals: An Exploratory Study of Electronic Medical Records
Authors: Torkman Reza , Ghapanchi Amir Hossein , Ghanbarzadeh Reza
Published: July 2024

Health information systems (HISs) are essential information systems used by organisations and individuals for various purposes. Past research has studied different types of HIS, such as rostering systems, Electronic Medical Records (EMRs), and Personal Health Records (PHRs). Although several past confirmatory studies have quantitatively examined EMR uptake by health professionals, there is a lack of exploratory and qualitative studies that uncover various drivers of healthcare professionals’ uptake of EMRs. Applying an exploratory and qualitative approach, this study introduces various antecedents of healthcare professionals’ uptake of EMRs. This study conducted 78 semi-structured, open-ended interviews with 15 groups of healthcare professional users of EMRs in two large Australian hospitals. Data analysis of qualitative data resulted in proposing a framework comprising 23 factors impacting healthcare professionals’ uptake of EMRs, which are categorised into ten main categories: perceived benefits of EMR, perceived difficulties, hardware/software compatibility, job performance uncertainty, ease of operation, perceived risk, assistance society, user confidence, organisational support, and technological support. Our findings have important implications for various practitioner groups, such as healthcare policymakers, hospital executives, hospital middle and line managers, hospitals’ IT departments, and healthcare professionals using EMRs. Implications of the findings for researchers and practitioners are provided herein in detail.
Ascarosides and Symbiotic Bacteria of Entomopathogenic Nematodes Regulate Host Immune Response in Galleria mellonella Larvae
Authors: Chantab Kanjana , Rao Zhongchen , Zheng Xuehong , Han Richou , Cao Li
Published: July 2024

Insects protect themselves through their immune systems. Entomopathogenic nematodes and their bacterial symbionts are widely used for the biocontrol of economically important pests. Ascarosides are pheromones that regulate nematode behaviors, such as aggregation, avoidance, mating, dispersal, and dauer recovery and formation. However, whether ascarosides influence the immune response of insects remains unexplored. In this study, we co-injected ascarosides and symbiotic Photorhabdus luminescens subsp. kayaii H06 bacteria derived from Heterorhabditis bacteriophora H06 into the last instar larvae of Galleria mellonella. We recorded larval mortality and analyzed the expressions of AMPs, ROS/RNS, and LPSs. Our results revealed a process in which ascarosides, acting as enhancers of the symbiotic bacteria, co-induced G. mellonella immunity by significantly increasing oxidative stress responses and secreting AMPs (gallerimycin, gloverin, and cecropin). This led to a reduction in color intensity and the symbiotic bacteria load, ultimately resulting in delayed host mortality compared to either ascarosides or symbiotic bacteria. These findings demonstrate the cross-kingdom regulation of insects and symbiotic bacteria by nematode pheromones. Furthermore, our results suggest that G. mellonella larvae may employ nematode pheromones secreted by IJs to modulate insect immunity during early infection, particularly in the presence of symbiotic bacteria, for enhancing resistance to invasive bacteria in the hemolymph.
IBD Patients with Primary or Secondary Nonresponse to Ustekinumab Benefit from Dose Escalation or Reinduction
Authors: Vernia Filippo , Monaco Sabrina , Latella Giovanni
Published: July 2024

Ustekinumab is a monoclonal antibody approved for the treatment of IBD. This drug has a well-established efficacy; however, patients may not respond or lose response. The availability of other biological therapies prompts the need for comparative data between different agents to suggest first- or second-line strategies. Aim of this review is to compare the effectiveness of ustekinumab to other biologics in Crohn’s disease and ulcerative colitis, as well as report the available data on dose escalation and reinduction. A systematic electronic search of the English literature was performed up to November 2023, using Medline (PubMed), Web of Science, Scopus and the Cochrane Library. Conference proceedings were also screened. Out of 659 citations, 80 relevant articles were selected and included in the present narrative review. Head-to-head comparisons of different biological drugs are relatively scarce, mostly deriving from indirect comparison or retrospective studies. Overall available data indicate similar effectiveness in the treatment of IBD patients. Dose escalation and reinduction strategies are well documented, but the optimal treatment schedule is still to be defined. Response and remission rates vary in different studies, and a proportion of patients fail to achieve clinical and endoscopic outcomes. However, both approaches are effective and safe in nonresponders and secondary loss of response. IBD patients may benefit from dose escalation or reinduction. Both strategies prove effective in regaining response in a proportion of patients, avoiding unnecessary early switch. Head-to-head trials are still needed to determine the exact placement of this drug compared to other biologics.
Arthroscopic Assessment of Temporomandibular Joint Pathologies—Is It Possible for Non-Specialists in Arthroscopy? Analysis of Variability and Reliability of Dental Students’ Ratings after a Comprehensive One-Semester Introduction
Authors: Brüning Lennard-Luca , Rösner Yannick , Meisgeier Axel , Neff Andreas
Published: July 2024

Background: Arthroscopy of the temporomandibular joint (TMJ) plays a long-established role in the diagnostics and therapy of patients suffering from arthrogenic temporomandibular disorders (TMDs), which do not respond adequately to conservative/non-invasive therapy. However, the interpretation of arthroscopic findings remains challenging. This study investigates the reliability and variability of assessing arthroscopic views of pathologies in patients with TMDs by non-specialists in arthroscopy and whether a standardized assessment tool may improve correctness. Methods: Following a comprehensive one-semester lecture, dental students in the clinical stage of education were asked to rate 25 arthroscopic views (freeze images and corresponding video clips) regarding the severity of synovitis, adhesions, and degenerative changes on a scale of 0–10 (T1). The results were compared to ratings stated by two European-board-qualified academic OMF surgeons. In a second round (T2), the students were asked to repeat the ratings using a 10-point rating scheme. Results: With regard to all three subcategories, congruency with the surgeons’ results at T1 was at a low level (p < 0.05 in 19/75 cases) and even decreased at T2 after the implementation of the TMDs-SevS (p < 0.05 in 38/75 cases). For both T1 and T2, therefore, the inter-rater agreement was at a low level, showing only a slight agreement for all three subcategories (Fleiss’ Kappa (κ) between 0.014 and 0.099). Conclusions: The judgement of the arthroscopic pathologies of the TMJ remains an area of temporomandibular surgery that requires wide experience and training in TMDs to achieve expertise in TMJ arthroscopic assessments, which cannot be transferred by theoretical instruction alone.
Performance of Massive Parallel Sequencing-Based Cell-Free DNA Testing in Compromised Pregnancies
Authors: Antolin Maria , Tarrasó Guillermo , Sánchez María Ángeles , Plaja Alberto , Martínez-Cruz Desiree , Xunclà Mar , Castells Neus , Carreras Elena , Tizzano Eduardo F. , García-Arumí Elena
Published: July 2024

Background/Objectives: Non-Invasive prenatal test (NIPT) is used as a universal or contingent test after prior risk assessment. Screening is mainly performed for common trisomies (T21, T13, T18), although other chromosomal anomalies may be detected. Our objective was to study the performance of GWNIPT in the detection of chromosomal abnormalities in pregnancies in which an invasive prenatal study was performed and in early pregnancy losses, in comparison with the reference test. Method: VeriSeqTM NIPT Solution v2, a genome-wide NIPT (GWNIPT), was performed prior to invasive testing in fetal diagnostic study cases (FDS, n = 155) and in early pregnancy losses (EPL, n = 68). Results: In the FDS group, the diagnostic test (QFPCR, array and karyotype) detected anomalies in 32 pregnancies (21%), in twenty of them (61%) also detected by GWNIPT. Eleven of the twelve cases undetected by GWNIPT were balanced translocations (n = 4) or deletions/duplications <7 Mb (n = 7). In the EPL group, GWNIPT detected anomalies in 46% of cases (31/68) but comparison with reference test (QFPCR and karyotype) in products of conception (POC) was only possible in 18 cases. Concordant results between POC and GWNIPT test were obtained in 16 of the 18 cases. In EPL, with GWNIPT testing, common trisomies accounted for 25.8% of cases (8/31), rare trisomies 54.8% (17/31) and microdeletions/duplications 16.1% (5/31). Conclusions: The GWNIPT test may be useful in clinical practice in prenatal and in EPL’s genetic diagnosis when the appropriate sample is not available.