bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation of starch-based cationic flocculants and its study on the removal of textile dyes
Authors: Chang Na , Cao Shuchen , Li Jiaqian , Zhang Hao , Wang Haitao
Published: July 2023

To effectively solve the problem of wastewater pollution. In this paper, a starch (St) based natural polymer cationic flocculant (DMSt-g-DMC) was prepared via a tetherification, esterification and grafting co-polymerization triple modification using corn starch as raw material, 3-chloro-2-hydroxypropyl triethylammonium chloride (CTA), vinyl acetate (VAC) and methylacryloxyethyltrimethyl ammonium chloride (DMC) were used as etherifying agents, esterifying agents and grafting monomers. The results by FT-IR, 13C NMR and XPS showed that acetyl, quaternary ammonium and DMC grafted chain segments were introduced into the starch macromolecular backbone. XRD, SEM analysis and polarized light observation showed that the structure of DMSt-g-DMC was disrupted water solubility was increased. Zeta potential test showed DMSt-g-DMC has increased positive charge quantity and isoelectric point PI. GPC analysis showed that DMSt-g-DMC maintained a high molecular weight and increased the degree of branching to improve flocculation performance. 94.1% removal of acid light yellow G by DMSt-g-DMC, 83.7% and 97.1% removal by reactive brilliant blue X-BR and direct lake blue 5B, respectively. St-g-DMC had a wide flocculation window from 5 g/L to 12 g/L. It also maintained good flocculation performance over a wide pH range. This is advantageous for treating wastewater with high alkalinity and complex composition.
MiR-130a-3p inhibits endothelial inflammation by regulating the expression of MAPK8 in endothelial cells
Authors: Gu Mingming , Liu Kun , Xiong Hui , You Qingsheng
Published: July 2023

MicroRNA-130a-3p (miR-130a-3p) has been reported closely related to atherosclerosis(AS). This study is to survey the effects of miR-130a-3p in endothelial cells (ECs) treated with oxidized low-density lipoprotein (ox-LDL) and explore underlying mechanisms. The proliferation and apoptosis of ox-LDL-treated HUVEC cells were determined by CCK-8, EdU and flow cytometry assays. ELISA and western blot analysis measured the expressions of cytokines and protein levels. Bioinformatics and dual-luciferase reporter assay were performed to predict and confirm that Mitogen-activated protein kinase 8 (MAPK8) was a direct target of miR-130a-3p, and MAPK8 was negatively associated with miR-130a-3p. As expected, miR-130a-3p was down-regulated in ox-LDL-treated HUVEC cells, and up-regulation of miR-130a-3p promoted proliferation and inhibited apoptosis of ox-LDL-treated HUVEC cells. Furthermore, miR-130a-3p mimics suppressed the expressions of TNF-α and IL-6 and decreased the protein levels of VCAM-1, ICAM-1 and E-selectin. MAPK8 was highly expressed in ox-LDL-treated HUVEC cells, and silence of MAPK8 promoted proliferation, inhibited apoptosis, suppressed inflammatory responses, and decreased the levels of VCAM-1, ICAM-1 and E-selectin, over-expression of MAPK8 partially restored the functional effects of miR-130a-3p on proliferation, inflammatory responses, and the expressions of VCAM-1, ICAM-1 and E-selectin. This study indicates that miR-130a-3p may emerge as an effective target for treating AS.
Future anti-Sleep Disorders agents: In silico virtual screening, Drug likness, ADMET and molecular docking and dynamics
Authors: Mkhayar Khaoula , Haloui Rachid , Daoui Ossama , khattabi Kaouakeb El , Rahman Shahedur , Chtita Samir , Elkhattabi Souad
Published: July 2023

The problem with sleep disorders is that they are frequent, often severe, and obstruct the patient's recovery and quality of life. Therefore, it is extremely important to identify new anti-Sleep Disorders agents. The objective of this research was to identify potent anti-sleep disorders agents using screening that combined molecular docking, dynamics. As part of this study, we have screened 20 compounds of Cannabis sativa L plants against orexin. Drug-like filters and ADMET analysis were used to refine the selected molecules. Based on the results of drug like and ADMET, we use the docking tools aids to visualizing and analysing protein-ligand complexes at the atomic level. In the end, two hits were chosen for molecular dynamics simulation. Results showed that two hits had potent inhibitory activity and excellent ADMET characteristics, and they might be used as new leads for the development of potent anti-sleep drugs. MD simulation study is applied for these two hits during 50 ns. As a result of these in-silico experiments, there is a strong basis for further investigation into their anti-Sleep properties.
Estimation of possible isothermal supersaturation of solutions in porous media
Authors: Tikhonov Nikolay
Published: July 2023

The phenomenon of isothermal supersaturation of solutions in a porous medium at ion exchange is studied on the basis of mathematical modeling. The phenomenon consists in the fact that the solution with concentration significantly higher than the maximal solubility of the substance is formed in the pores of sorbent and no precipitation occurs. The question of why sediment does not appear in the pores between the grains is investigated in the article. It is shown that the phenomenon under consideration can be explained by the effect of dynamic equilibrium between the association of condensed phase particles in the inner part of the pores, their diffusion, and decomposition near the surface of the sorbent grains caused by a change in potential. The degree of possible supersaturation of the solution is estimated depending on the process parameters. The proposed hypothesis is confirmed by quantitative studies using the available experimental data.
MSC Classification Codes: 93A30 - Mathematical modeling (models of systems, model-matching, etc.)
Therapist perspectives on telehealth-based virtual reality exposure therapy
Authors: Ong Triton , Wilczewski Hattie , Soni Hiral , Ivanova Julia , Barrera Janelle , Cummins Mollie , Welch Brandon , Bunnell Brian
Published: July 2023

Virtual reality (VR) can enhance mental health care. In particular, the effectiveness of VR-based exposure therapy (VRET) has been well-demonstrated for treatment of anxiety disorders. However, most applications of VRET remain localized to clinic spaces. We aimed to explore mental health therapists’ perceptions of telehealth-based VRET (tele-VRET) by conducting semi-structured, qualitative interviews with 18 telemental health therapists between October and December 2022. Interview topics included telehealth experiences, exposure therapy over telehealth, perceptions of VR in therapy, and perspectives on tele-VRET. Therapists described how telehealth reduced barriers (88.9%, 16/18), enhanced therapy (61.1%, 11/18), and improved access to clients (38.9%, 7/18), but entailed problems with technology (61.1%, 11/18), uncontrolled settings (55.6%, 10/18), and communication difficulties (50%, 9/18). Therapists adapted exposure therapy to telehealth by using online resources (66.7%, 12/18), preparing client expectations (55.6%, 10/18), and adjusting workflows (27.8%, 5/18). Most therapists had used VR before (72.2%, 13/18) and had positive impressions (55.6%, 10/18), but none had used VR clinically. In response to tele-VRET, therapists requested interactive session activities (77.8%, 14/18) and customizable interventions components (55.6%, 10/18). Concerns about tele-VRET included risks with certain clients (77.8%, 14/18), costs (50%, 9/18), side effects and privacy (22.2%, 4/18), and inappropriateness for specific forms of exposure therapy (16.7%, 3/18). These results show how designing for telehealth may extend VRET and can help inform collaborative development of health technologies.
The Prediction of Ultimate Base Shear of BRB frames under push-over using ensemble methods and Artificial neural networks
Authors: Al-Ghabawi Humam , Khattab Mustafa. M. , Zahid Idrees A. , Al-Oubaidi Bilal
Published: July 2023

This study aims to develop machine learning (ML) models that can predict the base shear of buckling restrained braced frames (BRBF). four machine learning (ML) algorithms (Random Forest, Artificial Neural Network (ANN), XGBoost, and Adaboost) were used to conduct this task. The training data were generated by conducting pushover analysis in OpenSeesPy. The BRBF model in OpenSeesPy considered both geometric and material nonlinearity. Six different configurations were used in this study. Each data point has unique frame properties (column, beam, BRB, boundary condition, leaning column and dead load, number of bays and stories, bay width, and story height). The learning and testing process were carried out for each BRB configuration individually and then combining the data of all the configurations. several statistical analyses were done to evaluate the prediction model and to study the importance of the BRBF properties based on their influence on the prediction. For that matter, the number of stories had the highest effect on the prediction values, and it shows the higher the number of stories the lower the maximum base shear that can be provided for that frame. The second most important feature is the core area of the BRB where increasing the core area increases the base shear and vice versa. Furthermore, XGboost showed the best predicted results followed by Adaboost, Random Forest, and Finally Artificial Neural Network (ANN). Finally, a graphical user interface based on the models was developed for the preliminary estimation of the base shear of buckling restrained braced frames.
Does the Opening of Ports and Trading Affect Long- term Green Economic Efficiency?Evidence from China’s Yangtze River Delta
Authors: Chen Haisheng , Shen Manhong
Published: July 2023

Taking the Yangtze River Delta of China as a case study, the SBM model GML index is used to measure urban green total factor productivity (GTFP), green technical efficiency (EC) and green technological progress (TC) respectively, and the multi-period spatial DID method is applied to empirically demonstrate the long-term heterogeneous effects of the late Qing Dynasty's open port and trade policy on urban green economic efficiency. The study concludes that (1) the late Qing Dynasty's policy of opening ports for trade objectively increased the city's long-term green total factor productivity (GTFP) and green technical efficiency (EC), but had an insignificant effect on green technological progress (TC). (2) The Treaty of Shimonoseki was a watershed in the long-term impact of the port-opening and trading policy on green economic efficiency, with the port-opening and trading policy implemented before 1895 boosting urban GTFP and EC, and the port-opening and trading policy implemented after 1895 having a negative impact on urban GTFP, EC and TC. (3) Long-term GTFP, EC and TC were negatively affected by the opening of ports and trading policies in cities where the governors were based, while opening of ports and trading policies in cities where the governors were not based had a positive effect on long-term GTFP, EC and TC. (4) Western powers following the civil law tradition had a more prominent long-term impact on the green economic efficiency of economically invaded cities than did common law countries. This paper appropriately verifies the long-term impact of open history on a city's green economic efficiency, which is instructive for better understanding, formulating and improving foreign opening policies in the new era.
Development of an Efficient, Effective, and Economical Technology for Proteome Analysis
Authors: Yu Yanbao , Martin Katherine , Le Ha , Yang Canyuan , Lu Guotao , Zhang Xiaohui , Grimes Catherine , Zhuang Zhihao , Asare-Okai Papa Nii
Published: July 2023

Proteomics experiments have typically high economic and technical barriers to broad biomedical scientists, which not only result in costly supplies and accessories for sample preparation but also the reluctance to adapt new techniques. In the present study, we present an effective and efficient, yet economical technology, which we call E3technology, for proteomics sample preparation. By immobilizing silica microparticles into a polytetrafluoroethylene (PTFE) matrix, we developed a novel medium, which could be used as a robust and reliable proteomics platform to generate LCMS-friendly samples in a rapid and low-cost fashion. Using different formats of E3technology, including E3tip, E3filter, E3cartridge, and E3plate, we explored a variety of sample types in varied complexity, quantity, volume, and size, including bacterial, fungi, mammalian cells, mouse tissue, and human body fluids. We benchmark their performance against several established approaches. Our data suggest that E3technology outperforms many of the currently available techniques in terms of proteome identification and quantitation. It is widely applicable, highly reproducible, readily scalable and automatable, and is user-friendly and stress-free to non-expert proteomics laboratories. It does not require specialized expertise and equipment, and significantly lowers the technical and economical barrier to proteomics experiments. An enhanced version, E4technology, also opens new avenues to sample preparation for low input and/or low-cell proteomics analysis. The presented technologies by our study represent a breakthrough innovation in biomedical science, and we anticipate widespread adoption by the proteomics community.
Structure-property relations in Pb-supersaturated metastable Sn-rich Pb-Sn alloys
Authors: Friák Martin , Čípek Petr , Pavlů Jana , Zobač Ondřej , Roupcová Pavla , Miháliková Ivana , Holec David , Msallamová Šárka , Michalcová Alena
Published: July 2023

We have performed a theoretical study of three different allotropes of Pb-supersaturated Sn-rich Pb-Sn alloys with the α-Sn, β-Sn and a simple hexagonal γ-Sn structure employing quantum-mechanical calculations. Structure-property relations were analyzed in the case of the lattice parameters, thermodynamic stability, elastic properties and mechanical stability as well as electronic-structure density of states. Compositional trends in structural, thermodynamic and electronic-structure properties were found nearly linear. Our theoretical study sheds new light on a decades-long controversy related to the γ-phase of supersaturated Sn-rich Pb-Sn alloys. We suggest that the experimental difficulties to synthesized the γ-phase solid solutions are due to the high formation energy of this phase.
Dead Man’s Cell Phone: Supernatural Interactions and the Ethics of Hyperconnectivity
Authors:   British And American Language And Literature Association Of Korea, Hong Eun-Sook
Published: July 2023

This paper focuses on the process of recovering supernatural interactions for all the characters in Dead Man’s Cell Phone. Sarah Ruhl is recognized as a playwright and thinker who expands cultural influence beyond the theatre through a conscious confrontation with the contemporary era. Dead Man's Cell Phones represents a new dimension of dramatic action that generates ‘freedom of hyperconnectivity,’ ‘hyper-connected survival,’ and ‘spiritual networks’ that humanity has neglected due to the temptation of materialism and technological advances. The play revolves around the dead man Gordon and his cell phone, exploring the human ontology that needs to be filled with meaning in the context of change and making connections among humans as well as humans and non-human others. Organ trading in Dead Man's Cell Phone is a dramatic motif that first appeared in English dramas. In this play, organ trading is a dramatic representation of the ethics of hyperconnectivity and raises ethical questions about the consequences of hyperconnectivity. This play demonstrates that drama is a platform for the transition of human life in restoring primitive connectivity in the hyper-connected era.
Food allergy and anaphylaxis to walnut
Authors: Ivanov A. A. , Esakova N. V. , Zimin S. B. , Gorev V. V. , Pampura A. N.
Published: July 2023

Among the wide variety of tree nuts, walnut is an allergen that deserves special attention in the context of acute allergic reactions, due to their severity, low inducing trigger dose, and minimal likelihood of developing tolerance. The overall consumption of walnut has been steadily increasing, while the importance of this allergen as a trigger for anaphylaxis is underestimated due to its often “hidden” presence in foods and the difficulty of trigger verification. This article presents the epidemiological aspects of walnut food allergy, provides current data on the molecular characteristics and properties of various allergen proteins, and their clinical significance for the development of anaphylaxis. The article is supplemented with two clinical cases of food anaphylaxis to walnuts from own clinical practice.
Ranking significance of risk factors in erosive and ulcerative lesions of the gastroduodenal zone in children
Authors: Kozhonazarova G. K.
Published: July 2023

The issue of erosive and ulcerative lesions of the stomach and duodenum is an urgent task for scientists, because, despite numerous studies and undoubted achievements in pediatric gastroenterology, many issues of etiopathogenesis are still not fully resolved and the incidence is steadily increasing.Purpose. To evaluate the risk factors for the occurrence of erosive and ulcerative lesions of the upper digestive tract in children.Materials and methods. We examined 1405 children from 2 to 17 years old with erosive and ulcerative lesions of the gastroduodenal zone, who were treated at the Department of Gastroenterology of the National Center for Maternal and Childhood Welfare (Kyrgyzstan) from 2010 to 2021. The study was conducted by questioning patients and their parents using a study-specific chart. The results were subjected to special statistical processing to study the rank significance of risk factors.Results. During the study, it was found that the first place is occupied by the pathology of the gastrointestinal tract up to 1 year, then, in terms of rank significance (in descending order of the OR value), the quality of nutrition, viral hepatitis А, diet, gastrointestinal diseases in relatives, pregnancy, neonatal pathology, and feeding follow.Conclusion. These facts are important for studying the processes of etiopathogenesis of erosive and ulcerative lesions of the gastrointestinal tract in children, which will later become the basis for creating an algorithm for managing this category of patients at all levels of healthcare.
Das falsas promessas de emprego e sua relação com o tráfico de seres humanos diante da pandemia da Covid-19
Authors: Cunha Bezerra Germano , Alexsandra de Melo Pedroso Vanessa
Published: July 2023

Tem-se um problema que há décadas, quiçá séculos, aflige milhares de pessoas – em sua grande maioria provenientes de grupos vulneráveis – qual seja, o tráfico de seres humanos. Além da fragilidade das vítimas tem-se que o desemprego, a desigualdade social, a falta de perspectiva de melhorias, a instabilidade financeira e a inconstância política contribuem para que mais pessoas se tornem vítimas dos criminosos. Percebe-se desde meados do mês de março de 2020 um grave problema oriundo da pandemia da Covid-19 – que além de milhares de mortes direcionou outras tantas à pobreza – em razão do fechamento de postos de trabalho e consequente aumento do desemprego. Assim, por óbvio, tal problemática social ampliará significativamente a possibilidade de mais pessoas tornarem-se vítimas dos traficantes de pessoas ao serem ludibriadas por falsas promessas de emprego. Busca-se no presente artigo não apenas prevenir aqueles que podem ser induzidos a erro, mas também sensibilizar as autoridades envolvidas na investigação do caso concreto de que, por trás de uma mera promessa vazia de emprego, pode existir o escopo da prática de crimes. Para tanto, empregamos a averiguação de situações fáticas e reais do mundo concreto e utilizamos a análise de jurisprudências, explanações doutrinárias e da apreciação de dados concretos, visando a demonstrar a necessidade de estarmos atentos às falsas promessas de emprego que surgirão, as quais poderão estar mascaradas e que terão como único fim a exploração de pessoas para o tráfico de seres humanos.
Percebe-se desde meados do mês de março do ano de 2020 um grave problema oriundo da pandemia da COVID-19 - que além de milhares de mortes direcionou outras tantas à pobreza - em razão do fechamento de postos de trabalho e consequente aumento do desemprego. Assim, por óbvio, tal problemática social ampliará significativamente a possibilidade de mais pessoas tornarem-se vítimas dos traficantes de pessoas ao serem ludibriadas por falsas promessas de emprego.
Busca-se no presente artigo não só prevenir aqueles que podem ser induzidos a erro, mas também sensibilizar as Autoridades envolvidas na investigação do caso concreto de que, por trás de uma mera promessa vazia de emprego, pode existir o escopo da prática de crimes. Para tanto, empregamos a averiguação de situações fáticas e reais do mundo concreto e utilizamos da análise de jurisprudências, explanações doutrinárias e da apreciação de dados concretos; visando demonstrar a necessidade de estarmos atentos às falsas promessas de emprego que surgirão, as quais poderão estar mascaradas e que terão como único fim a exploração de pessoas para o tráfico de seres humanos.
Auto-enhanced population diversity and ranking selection-based differential evolutionary algorithm applied to the optimal design of water distribution system
Authors: Du Kun , Xiao Bang , Xu Wei , Liu Zilian , Song Zhigang , Tang Zhiyi , Zheng Feifei
Published: July 2023

The differential evolution (DE) algorithm is considered the most powerful evolutionary algorithm (EA) for the optimal design of water distribution systems (WDSs). However, when dealing with large-scale WDS optimization, issues such as premature convergence become a concern. This paper presents an auto-enhanced population diversity and ranking selection-based differential evolutionary (AEPD-RSDE) algorithm for the optimal design of WDSs, which is the first work that incorporates an AEPD strategy to avoid the premature convergence issue and enhance the exploration ability of DE applied to WDS optimization. Besides, the proposed algorithm includes a ranking selection strategy that replaces the tournament selection operator to enhance convergence speed. Three well-known WDSs, i.e., the New York Tunnels (NYT), the Hanoi network (HAN), and the Balerma irrigation network (BIN), were used to validate the proposed algorithm. Results indicate the proposed algorithm is able to find the current best solution, with a success rate of 100% for the NYT and HAN cases and lower average cost solution of €1.921 million for the BIN case relative to other EAs. Instead of solely focusing on ultimate performance comparison, search behavior analyses are conducted between different mutation and selection operators, offering deep insight to guide the development of more advanced EAs.
Trends in the Development of the Subjects of the Russian Federation under Sanctions
Authors: Valentey S. D. , Bakhtizin A. R. , Borisova S. V. , Kol’chugina A. V. , Lykova L. N.
Published: July 2023

For the period from 2020 to the present, both the domestic economy and the economies of the constituent entities of the Russian Federation have been subjected to two shocks. The shock caused by COVID-19 and the shock caused by the sanctions policy against Russia. As our research has shown, regional economies have relatively successfully overcome the negative consequences of the pandemic, suffering fewer losses than initially hypothetically predicted. An attempt to determine the degree of negative consequences of sanctions at the regional level is made in this article. At the same time, the authors understand that the problem requires further research, because, firstly, the impact of covid and post-covid restrictions on the national and regional economies has not been completely overcome. Secondly, since sanctions were introduced (and are being introduced) not simultaneously, but incrementally, they affect (and will affect) regional economies with different industry specialization of enterprises in different ways.
Medicinal Plants for the Treatment of Neuropathic Pain: A Review of Randomized Controlled Trials
Authors: Ahmadzadeh Amir Mahmoud , Pourali Ghazaleh , Mirheidari Seyed Behzad , Shirazinia Matin , Hamedi Mahdieh , Mehri Ali , Amirbeik Hesam , Saghebdoust Sajjad , Tayarani-Najaran Zahra , Sathyapalan Thozhukat , Forouzanfar Fatemeh , Sahebkar Amirhossein
Published: July 2023

Neuropathic pain is a disabling condition caused by various diseases and can profoundly impact the quality of life. Unfortunately, current treatments often do not produce complete amelioration and can be associated with potential side effects. Recently, herbal drugs have garnered more attention as an alternative or a complementary treatment. In this article, we summarized the results of randomized clinical trials to evaluate the effects of various phytomedicines on neuropathic pain. In addition, we discussed their main bioactive components and potential mechanisms of action to provide a better view of the application of herbal drugs for treating neuropathic pain.
Emerging Therapies and Therapeutic Targets for Composite Liver Disease: NASH
Authors: Sobhia M. Elizabeth , Kumari Sonia , Kumar Harish , Gandhe Akshata , Kaushik Dhriti , Kumar Harish , Jain Jethender , Ankita  , Mallick Moyim , Pavani Bommana , Moudgil Mridula , Patel Deepesh
Published: July 2023

Background:

Liver diseases continue to destroy the lives of people, one of which is known as Non-alcoholic Steatohepatitis (NASH) that becomes a serious liver disease all around the world over the last few years. Non-alcoholic Steatohepatitis (NASH) is a progressive form of Nonalcoholic Fatty Liver Disease (NAFLD) and is characterized by liver steatosis, inflammation, different degrees of fibrosis, and hepatocellular injury. The inflammatory mediators play a vital role in the transition of Non-alcoholic Fatty Liver (NAFL) to Non-alcoholic Steatohepatitis (NASH), which further leads to Hepatocellular Carcinoma (HCC) and becomes a cause of liver transplantation.

Objective:

Considering the severity and complexity of the disease, we aim to summarize the works of various research groups that are working in the area of NASH to find a sophisticated treatment.

Results:

The present review focused on various factors that are responsible for the development and progression of this prevalent disease, emerging pharmacotherapies as well as therapeutic targets that have been utilized for the treatment of NASH. We also have conducted the structural analysis of available targets, which will be helpful for the enhancement of drug discovery through the implementation of in silico methods.

Conclusion:

Efforts have been made to provide an update on research in the area of NASH, including the pharmacological agents that are currently undergoing clinical trials for the treatment of NASH. Besides the massive research, still, gaps and challenges are there in the drug development for NASH that also have been discussed.
Proteome Profiling of Serum Exosomes from Newborns with Lung Injury after Perinatal Asphyxia
Authors: Shen Feifei , Li Ying , Gu Wenjing , Yu Xingmei , Wu Youjia , Suo Guihai , Zheng Yuqin , Li Haiying , Hao Chuangli
Published: July 2023

Background:

Neonate lung injury is a common phenomenon after perinatal asphyxia.

Objective:

To evaluate proteomic profiles of exosomes isolated from lung injury offspring serum after perinatal asphyxia.

Methods:

Serum samples were collected at 12 h, 24 h, and 72 h after birth in neonates with perinatal asphyxia-induced lung injury. Exosomes were isolated, and the concentration and size distribution were assessed. The exosome surface markers CD9, CD63, CD81, HSP70, and TSG101 were detected by Western blot. The exosome proteins were evaluated by quantitative proteomics using a tandem mass tag (TMT). All the identified proteins were submitted to the Weighted Gene Co-Expression Network Analysis (WGCNA), GO function, and KEGG pathway analysis. A protein-protein interaction network (PPI) was utilized to identify hub proteins with the Cytohubba plugin of Cytoscape.

Results:

The exosomes were round or oval vesicular structures at a diameter range of 100-200 nm, and the size distribution was standard and consistent. Exosome surface markers CD9, CD63, CD81, HSP70, and TSG101 were detected. 444 out of 450 proteins were mapped with gene names. A brown module containing 71 proteins was highly linked with the 12 h phenotype and was predominantly concentrated in lipoprotein and complement activation. The top 10 proteins, APOA1, APOB, APOE, LPA, APOA2, CP, C3, FGB, FGA, and TF, were determined as hub proteins.

Conclusion:

The present study demonstrates comprehensive information for understanding molecular changes of lung injury following perinatal asphyxia, which provides a reliable basis for screening potential biomarkers and therapeutic targets in the clinic.
Fragment-based Drug Discovery Successful Contributions to Current Pharmacotherapeutic
Agents Arsenal against Aggressive Cancers: A Mini-Review
Authors: Santos Leandro Marcos , da Silveira Nelson José Freitas
Published: July 2023

After a decade of approval of the drug vemurafenib in 2011, the hopeless scenario imposed by some severe
cancer types has been mitigated by the magic bullets developed through fragment-based drug discovery. Moreover, this
recent approach to medicinal chemistry has been successfully practiced by academic laboratories and pharmaceutical
industry workflows focused on drug design with an enhanced profile for chemotherapy of aggressive tumors. This
mini-review highlights the successes achieved by these research campaigns in the fruitful field of the molecular fragment
paradigm that resulted in the approval of six new anticancer drugs in the last decade (2011-2021), as well as
several promising clinical candidates. It is a particularly encouraging opportunity for other researchers who want to
become aware of the applicability and potency of this new paradigm applied to the design and development of powerful
molecular weapons in the constant war against these merciless scourges of humanity.
CD163 as a Potential Biomarker-associated Immune Inflammation in
Diabetes Mellitus: A Systematic Review and Bioinformatics Analysis
Authors: Cao Yang , Liang Ning , Kong Kaili , Qiao Xiaomei , Liu Ting , Fang Jing-ai , Zhang Xiaodong
Published: July 2023

Background:

Several studies have identified CD163 as a potential mediator of diabetes melli-tus through an immune-inflammation. Further study is necessary to identify its specific mechanism.

Objective:

In this study, we aimed to investigate CD163 as a potential biomarker associated with immune inflammation in diabetes mellitus through a systematic review and bioinformatics analysis.

Methods:

We searched PubMed, Web of Science, the Cochrane Library, and Embase databases with a time limit of September 2, 2022. Furthermore, we conducted a systematic search and review based on PRISMA guidelines. Additionally, diabetic gene expression microarray datasets GSE29221, GSE30528, GSE30529, and GSE20966 were downloaded from the GEO database (http://www.ncbi.nlm.nih.gov/geo) for bioinformatics analysis. The PROSPERO number for this study is CRD420222347160.

Results:

Following the inclusion and exclusion criteria, seven articles included 1607 patients, comprising 912 diabetic patients and 695 non-diabetic patients. This systematic review found significantly higher levels of CD163 in diabetic patients compared to non-diabetic patients. People with diabetes had higher levels of CRP expression compared to the control group. Similarly, two of the three papers that used TNF-α as an outcome indicator showed higher expression levels in diabetic patients. Furthermore, IL-6 expres-sion levels were higher in diabetic patients than in the control group. A total of 62 samples were analyzed by bioinformatics (33 case controls and 29 experimental groups), and 85 differential genes were identified containing CD163. According to the immune cell correlation analysis, CD163 was associated with mac-rophage M2, γδ T lymphocytes, macrophage M1, and other immune cells. Furthermore, to evaluate the diagnostic performance of CD163, we validated it using the GSE20966 dataset. In the validation set, CD163 showed high diagnostic accuracy.

Conclusion:

This study suggests CD163 participates in the inflammatory immune response associated with diabetes mellitus and its complications by involving several immune cells. Furthermore, the results suggest CD163 may be a potential biomarker reflecting immune inflammation in diabetic mellitus.
Preparation and Application of Plant-derived Biochar
Authors: Fu Li
Published: July 2023

Plant-derived biochar is derived from biomass as a carbon source. It has a
large specific surface area, high pore capacity, adjustable surface functional groups,
and good environmental compatibility. Its raw material, plant-derived biomass, is
widely available and renewable. It is a cheap and efficient adsorbent. Most biochar
contains more than 70 percent carbon. Biochar can adsorb heavy metal ions, hormones,
and organic pollutants. It can also be used for soil improvement, carbon sequestration,
and the development of new materials with BC as the main component. In this chapter,
biochar preparation and plants’ selection are introduced. How to characterize biochar is
also discussed. In addition, biochar adsorption applications in different fields are also
introduced.
Plant Tissues as Templates for Morphology Genetic Material Synthesis
Authors: Fu Li
Published: July 2023

In order to ensure the needs of survival and reproduction, plants have
formed various, diverse, multi-dimensional, and multi-scale fine and subtle
configurations for millions of years, which provides rich inspiration for scientific
research in many fields today. Research on morphology genetic material converts
natural biological components into target materials by directly using biological
structures as templates and selecting appropriate physicochemical methods while
maintaining the fine-graded structure of the template. It can be used to prepare new
functional materials with a biological finely-graded structure. This section describes
methods for preparing functional materials with biological structures using morphology
genetic material research ideas. In this chapter, we briefly introduce the structure of
residual materials prepared by using several typical plant structures as templates, and
discuss the related functional performance of materials with different structural
characteristics. 
Christine Delphy, an Anti-essentialist TERF: Materialist Feminism and the Affective Legacies of the MLF
Authors: Costello Katherine
Published: July 2023

For the last decade, Christine Delphy, one of the most important feminists in France, has taken profoundly reactionary positions in relation to transgender people, that qualify her as a trans-exclusionary radical feminist (TERF). But while most TERF discourse relies on biological essentialism, Delphy is radically anti-essentialist. As early as 1981, she showed that both gender and sex are socially constructed, a premise that has become a cornerstone of transgender studies. How is one to understand the fact that a feminist whose thinking would seem to inscribe itself in the direction of transfeminism allies herself with the TERF movement? This essay shows that her theoretical arguments against transness can be overcome from a materialist feminist perspective and argues that her transphobia is bound up in the affective aftermath of conflicts in the women’s liberation movement that were cemented through a complex transatlantic intellectual history and never resolved.
Dialogue and Repertoire: The Ever-Changing Nature of Walking and Talking Together
Authors: Maciel Andrea , Taylor Diana
Published: July 2023

This conversation between Professor Diana Taylor and Dr. Andrea Maciel presents Taylor’s life-long experience fostering art and activism, as well as promoting dialogical research encounters through The Hemispheric Institute of Performance & Politics. The discussion encompasses the role of the archive as part of a mutual collaboration between performance and practice as research whilst opening a critical inquiry on how new epistemologies for artists and researchers can contemplate the archive as a force for the creation of laboratorial praxis.  Drawing on her long experience as a core member of Cross Pollination (CP), an international arts research platform for the exchange of knowledge and nomadic laboratory spaces, Maciel invites Taylor to also reflect about the power of performances and somatic practices to trace trauma related to social cultural alienation and oppression.
Like the space in-between beats :a dialogue on dialogues
Authors: Nie Marije Sanneke , van den Berg Lotte
Published: July 2023

This article transmits a dialogue between two theatre practitioners: theatre maker Lotte van den Berg, co-founder of Building Conversation, and performer/creator Marije Nie, co-founder of the Parliament of Practices and the Cross Pollination collective. The dialogue is not an argument or a debate, it is an encounter in the space in-between, in-between our practises, experiences, professional ethos and praxis as theatre-makers. It is an exercise in inviting the swirls and eddies of thoughts and impulses and following them, with care. The text follows the meandering path of the dialogue, both an exchange and a search for a state of being together that allows thoughts to emerge and take flight while staying connected to our centres, like in a physical theatre training.
Cómo cultivar sus hortalizas aromáticas en casa :agricultura urbana
Authors: Paredes Zambrano Guillermo Alfredo
Published: July 2023

La presente cartilla técnica contribuye a la capacitación en agricultura urbana y ofrece un medio de consulta para los productores urbanos que ya están cultivando alimentos en sus casas y quieran mejorar sus huertas y sus hábitos alimenticios, contibuyendo a la seguridad alimentaria, a la economía familiar, creación de espacios verdes y decorativos y fomentar el consumo de hortalizas, mejorando el bienestar y salud de las familias.
Effectiveness of Telecare Interventions on Depression Symptoms Among Older Adults: Systematic Review and Meta-Analysis (Preprint)
Authors: Wu Man , Li Chaoyang , Hu Ting , Zhao Xueyang , Qiao Guiyuan , Gao Xiaolian , Zhu Xinhong , Yang Fen
Published: July 2023

BACKGROUND

Depression is the most common psychiatric disorder among older adults. Despite the effectiveness of pharmacological and psychological therapies, many patients with late-life depression (LLD) are unable to access timely treatment. Telecare has been shown to be effective in addressing patients' psychosocial issues, while its effectiveness in serving patients with LLD remains unclear.

OBJECTIVE

This study aimed to evaluate the effectiveness of telecare in reducing depression and anxiety symptoms and improving quality of life (QoL) in patients with LLD.

METHODS

Databases including the Cochrane Library, Web of Science, PubMed, Embase, and EBSCO were searched for randomized controlled trials (RCTs) evaluating the effectiveness of telecare for LLD from database establishment to December 28, 2022.

RESULTS

A total of 12 RCTs involving 1663 participants were identified in this study. The meta-analysis showed that (1) telecare significantly reduced depressive symptoms in patients with LLD compared to those in usual care (UC; standardized mean difference [SMD]=–0.46, 95% CI –0.53 to –0.38; P<.001), with the best improvement observed within 3 months of intervention (SMD=–0.72, 95% CI –1.16 to –0.28; P<.001); (2) other scales appeared more effective than the Patient Health Questionnaire-9 for LLD in telecare interventions (SMD=–0.65, 95% CI –0.96 to –0.35; P<.001); (3) telecare was more effective than telephone-based interventions for remote monitoring of LLD (SMD=–1.13, 95% CI –1.51 to –0.76; P<.001); (4) the reduction of depressive symptoms was more pronounced in patients with LLD with chronic conditions (SMD=–0.67, 95% CI –0.89 to –0.44; P<.001); (5) telecare was more effective for LLD in Europe and the Americas than in other regions (SMD=–0.73, 95% CI –0.99 to –0.47; P<.001); (6) telecare significantly reduced anxiety symptoms in patients with LLD (SMD=–0.53, 95% CI –0.73 to –0.33; P=.02); and (7) there was no significant improvement in the psychological components of QoL in patients with LLD compared to those receiving UC (SMD=0.30, 95% CI 0.18-0.43; P=.80).

CONCLUSIONS

Telecare is a promising modality of care for treatment, which can alleviate depression and anxiety symptoms in patients with LLD. Continued in-depth research into the effectiveness of telecare in treating depression could better identify where older patients would benefit from this intervention.
Discrete Communication Systems - Review
Authors: Berber Stevan
Published: July 2023

n/a
The Effect of Digital Finance on Rural Revitalization
Authors: Wang Jiatong , Tong Niancheng
Published: July 2023

Digital finance is gradually becoming an important source of strength to promote rural revitalization. In order to give full play to the role of digital finance in promoting rural revitalization, based on the provincial panel data of China from 2011 to 2021, this paper constructs rural revitalization indicators and explores the effect of digital finance on rural revitalization. It is found that the development of digital finance has a significant effect on rural revitalization; Digital finance has a positive impact on rural revitalization by improving the level of urban-rural integration, promoting agricultural modernization and boosting economic growth; In high-income areas, digital finance plays a more significant role in promoting rural revitalization; The higher the level of digital finance, the better it can play a role in promoting rural revitalization.
OVERVIEW ON CARBONDOTS
Authors: SINHA PRIYANKA , RATHNAM GRACE , S. M. DAN KASPERO , N. JAGAN KARTHICK
Published: July 2023

As a prospective material for biosensing, drug administration, and bioimaging, carbon dots (C-dots) have grown in popularity due to their outstanding visual characteristics, great biocompatibility, and low cytotoxicity. As a result, there has been a lot of curiosity about the development, characteristics, and potential applications of CDOTs. Based on variations in precursors and methods of preparation, CDOTs were divided into two classes. The procedure for the formation of CDots was outlined, and their luminescence process was investigated. Also presented were CDOTs' uses in biosensing, medication administration, and bioimaging. For their continued development, CDOTs' challenges and challenges were reviewed.
AN OUTBREAK OF SCRUB TYPHUS IN A REMOTE VILLAGE-AN OVERVIEW
Authors: BHARATHI M. , KALYANI C. SIVA , SIRISHA T.
Published: July 2023

Objective: An outbreak of scrub typhus was declared by Public Health authorities in our district in October, 2022. To investigate this a team of experts from Microbiology, SPM, Medicine and Pediatric Medicine was sent to the place of outbreak and they observed that there was heavy vegetation, stagnant water, dwellings heavily infested with rodent population. There was heavy rain in the past two weeks in the district. To investigate the cause of sudden upsurge of febrile illness cases. Methods: Blood samples were collected from 28 persons who were symptomatic with fever/headache/diarrhea/rash and myalgia to do tests for Scrub typhus, Typhoid fever, Malaria, Dengue, Complete blood count, CRP, LFT and KFT. The samples which were positive for Scrub typhus in rapid test kits were subjected for IgM ELISA to confirm scrub typhus. Results: Seven of twenty-eight patients tested positive for scrub typhus by rapid test (25%), and four of them were positive by IgM ELISA (14.28%). Three patients were Widal-positive (10.7%). More than half samples showed increased CRP levels (53.57%). Thrombocytopenia and mild leucocytosis was observed in scrub typhus cases (42.85%) as well as in typhoid cases. Conclusion: Any outbreak during monsoon should be investigated thoroughly not only for the specified disease but also for all infectious diseases that are prevalent in that area.
EFFECTIVENESS OF PLATELET TRANSFUSION IN DENGUE PATIENTS IN A TERTIARY CARE HOSPITAL
Authors: V. VIJAY ANAND , SHARMA ANKIT
Published: July 2023

Objective: Dengue has been emerging as rapidly spreading and dreaded mosquito-borne disease caused by the bite of Aedes Aegypti Mosquito. Clinical features are variable and presents with Dengue fever or Dengue Hemorrhagic fever or more severe Dengue shock syndrome. Thrombocytopenia is presenting feature in all Dengue cases and some often presents with bleeding. Platelet transfusions are given in patients with haemorrhagic symptoms. While medical fraternity globally recognizes the role of platelet transfusion in the management of hospitalized dengue patients the exact indications and situations in which these are to be transfused may vary. Since there is inherent risk associated with the transfusion of blood/blood-component, it is imperative for each institution (or country) to lay their own criteria for transfusion of these blood components. The present study was conducted to lay precise criteria and transfusion trigger for platelet transfusion in our setup.

Methods: The present study was conducted on 225 serologically confirmed dengue patients admitted at sawaimansign Hospitals between 1" of August to 30th of November 2022. Clinical data, reports of hematological investigation, platelets requirements and data obtained from SHealth services.

Results: In the serologically confirmed cases, the prevalence of thrombocytopenia (count less than 100,000/cumm) was 84.88% on admission and bleeding was recorded in 22 (9.7%) patients. About 96 (42.6%) patients of dengue cases received platelet transfusion. Among them 47 (20.88%) patients had a platelet count<20,000/cumm, 43 (19.11%) had a platelet count in the range of 21-40.000/cumm, while 6 (2.66%) patients had the platelet count in between 41 and 50.000/cumm. Out of 49 patients with a platelet count>20,000/cumm, 18 patients had hemorrhagic manifestations such as petechiae, gum-bleeding, epistaxis, etc., which necessitates the use of platelet transfusion. However, 31 patients received inappropriate platelet transfusion.

Conclusion: This study suggests that bleeding occurs more often in patients with severe thrombocytopenia. High-risk patients having platelet count<20,000/cumm and risk of bleeding require urgent platelet transfusion. Patients with a platelet count 21-40,000/cumm are in moderate risk and require platelet transfusion only if they have any haemorrhagic manifestations and other superadded conditions.
ROLE OF ULTRASOUND AS PROGNOSTIC INDICATOR DURING PRONSETI CORRECTION
Authors: GUPTA NAVEEN , THAKUR AMIT , GAUTAM DIXIT
Published: July 2023

Objective: Clubfoot ultrasonography is an objective means of determining severity. The purpose of this study is to evaluate the reliability of measuring clubfoot severity by sonographic evaluation of the talonavicular angle (TNA) and the reliability of assessing angle change on simulated Ponseti manipulation.
Methods: Twenty-six infants with unilateral idiopathic clubfoot were evaluated prospectively using clinical scoring and Pirani scoring and sonographic measurements of TNA at the start of treatment, after midfoot correction, and after the complete correction was achieved. The TNA and its change during simulated Ponseti manipulation were recorded.
Results: In static posture, the mean TNA of the clubfoot (66.46°) differed substantially from that of the contralateral normal foot (101.3°). The mean shift in TNA after simulated Ponseti manipulation was 22.54° (5-50°), and it correlated negatively with clinical ratings and the total number of casts required for final correction (p<0.05). Linear regression research demonstrated that the change in TNA on simulated Ponseti manipulation was the strongest predictor of treatment outcome in CTEV (with a prediction of 60% compared to 25% for Pirani scores).
Conclusion: The severity of clubfoot in babies can be better accessed via sonographic examination of TNA and change in TNA following simulated Ponseti manipulation. This objective form of assessment is less expensive, more reproducible in clinical settings, and can better predict treatment outcomes.