bluuebunny/crossref_metadata_2025 huggingface dataset:
Water resource safety assessment and limiting factor diagnosis based on improved concept and matter–element analysis models: a case study of a typical karst area in southwest China
Authors: Peng Tao , Zhao Lei , Wang Peng
Published: December 2024

Water is an important strategic resource for sustainable development and a basic element for ecological environment construction, especially in the karst areas of southwest China. Based on the concept model of drive, pressure, engineering water shortage, status, ecological foundation, and response (DPESFR), we built a comprehensive assessment indicator system based on the characteristics of karst water resources. The entropy-weighted right, CRITIC, and analytic hierarchy process methods were used to determine three types of basic weights, and the coordinated weights of all indicators were obtained by combining the thought method of game theory. The matter–element analysis model was then used to calculate the water resource safety situation of Guiyang from 2013 to 2022, and the limiting factors were explored using the limiting degree model. Finally, the autoregressive integrated moving average (ARIMA) model was used to predict water resource safety of Guiyang from 2023 to 2030. The results of these analyses were as follows: (1) the integral situation of the water resource safety in Guiyang showed an annual downward trend. The water resource safety was found to be grade IV from 2013 to 2017 and grade III from 2017 to 2022; from 2023 to 2030, the integral water resource safety grade is expected to continue decreasing, with the integral level expected to remain at grade III. (2) In six subsystems of the criterion layer, the key limiting factors affecting the water resource safety of Guiyang were the “state” subsystem, followed by the “response” and “drive” subsystems, with the indicators under different subsystems being different. (3) The most influential factors limiting the degree were concentrated in the “state” subsystem, followed by the “response” subsystem, indicating that both human activities and natural conditions significantly impact water resource safety in Guiyang. By identifying and analyzing the indicators affecting water resource safety in Guiyang, it is seen that measures such as controlling the total amount of industrial wastewater discharge, improving the treatment rates of domestic sewage, ensuring ecological water usage, and promoting water-saving technologies are important prerequisites for ensuring water resource safety in Guiyang.
Exploring lymphocyte subsets in COVID-19 patients: insights from a tertiary academic medical center with a high proportion of patients on immunosuppression
Authors: Daenen Katrijn , van Hooijdonk Samantha , Tong-Minh Kirby , Dik Willem A. , van Hagen Petrus M. , Huijben Jilske A. , Gommers Diederik , van Gorp Eric C. M. , Endeman Henrik , Dalm Virgil A. S. H.
Published: December 2024

Introduction

Severe COVID-19 is associated with reduced absolute lymphocyte counts, suggesting that lymphocyte subsets may serve as predictors of clinical outcomes in affected patients. Early identification of patients at risk for severe disease is crucial for optimizing care, accurately informing patients and their families, guiding therapeutic interventions, and improving patient flow in the ED. Given that immunosuppressive drugs significantly impact lymphocyte profiles, we aimed to determine the association between prior use of immunosuppressive drugs, lymphocyte subsets, and COVID-19 severity in our population with a high prevalence of immunosuppression.

Methods

In 2021, suspected COVID-19 patients were included in the ED. Lymphocyte subsets were determined in peripheral blood within 24 hours after presentation and comparative analyses was performed between SARS-CoV-2 negative and positive patients, mild versus severe disease and patients with and without prior immunosuppressive drug use. Mild cases were patients discharged home or admitted to a general ward, severe cases were patients with COVID-19-related mortality or necessitating ICU admission. Logistic regression analysis was performed to assess the association between lymphocyte subsets and COVID-19 severity, and between prior immunosuppressive drug use and COVID-19 severity.

Results

Twenty-five SARS-CoV-2 negative and 77 SARS-CoV-2 positive patients were included, whereof 57 (74%) had mild and 20 (26%) severe COVID-19. No significant differences were observed in the absolute counts of CD3+, CD4+, and CD8+ T-lymphocytes, B-lymphocytes, and NK-cells between SARS-CoV-2 negative and positive patients or between mild and severe cases. The 36 patients with prior use of immunosuppressive drugs had significantly lower CD4+ T-lymphocytes (p<0.01). Prior use of immunosuppressive drugs was not associated with COVID-19 severity (adjusted OR 1.074, 0.355-3.194).

Conclusion

Lymphocyte subsets were not significantly different between SARS-CoV-2 negative and positive patients and between mild versus severe cases. Neither lymphocyte subsets nor prior immunosuppressive drug use were associated with COVID-19 severity.
Genetically predicted serum metabolites mediate the association between inflammatory proteins and polycystic ovary syndrome: a Mendelian randomization study
Authors: Jia Ming-Jie , Zhou Li , Liu Xing-Ning , Li Hui-Lin
Published: December 2024

Objective

To investigate the association between polycystic ovary syndrome (PCOS) and inflammatory proteins, and to identify and quantify the role of serum metabolites as potential mediators.

Methods

Utilizing summary-level data from a genome-wide association study (GWAS), we conducted a two-sample Mendelian Randomization (MR) analysis, a genetic approach that uses genetic variants as instrumental variables to assess the causal relationships between risk factors and outcomes. This analysis involved genetically predicted PCOS (1,639 cases and 218,970 controls) and inflammatory proteins (14,824 participants of primarily European descent). Additionally, a two-step MR analysis was performed to quantify the proportion of the effect of serum metabolites-mediated inflammatory proteins on PCOS. The Inverse Variance Weighted (IVW) method, a statistical technique used within MR to combine data from multiple genetic variants, was used to estimate the causal effects.

Results

The IVW method revealed that the inflammatory proteins IFN-γ (p-value = 0.037, OR = 1.396, 95% CI = 1.020–1.910) and CCL7 (p-value = 0.033, OR = 1.294, 95% CI = 1.021–1.641) were associated with an increased risk of PCOS, while IL-6 (p-value = 0.015, OR = 0.678, 95% CI = 0.495–0.929) and MMP-10 (p-value = 0.025, OR = 0.753, 95% CI = 0.587–0.967) were associated with a decreased risk. No significant evidence suggested an effect of genetically predicted PCOS on inflammatory proteins. The serum metabolite X-11444 was found to mediate 5.44% (95% CI: 10.8–0.0383%) of the effect of MMP-10 on PCOS.

Conclusion

This study not only introduces novel causal associations between inflammatory proteins and PCOS but also highlights the mediating role of serum metabolites in these associations. By applying MR, we were able to minimize confounding and reverse causality, offering robust insights into the biological mechanisms underlying PCOS. These findings advance the understanding of PCOS pathogenesis, particularly in relation to inflammatory pathways and serum metabolite interactions, and suggest potential therapeutic targets that could inform future clinical interventions aimed at mitigating inflammation-related PCOS risks.
Observation on the therapeutic effect of probiotics on early oral feeding in the treatment of severe acute pancreatitis
Authors: Zhao Yanan , Zhang Rui , Wang Shuling , Yang Chunchun , Wang Yang , Fan Hongyun , Yang Mingyue
Published: December 2024

Objectives

To evaluate the clinical efficacy of probiotics and early oral feeding in patients with severe acute pancreatitis.

Methods

A prospective, randomized, controlled trial was conducted involving 66 patients, who were randomly divided into a control group (n = 32) receiving standard enteral nutrition and an observation group (n = 34) receiving additional Bifidobacterium quadruplex live bacterial tablets. Serum inflammatory markers, including white blood cells (WBC), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP), were measured on days 1, 3, and 7 post-admission. Abdominal pain scores, the computed tomography severity index (CTSI), and the Bedside Index for Severity in Acute Pancreatitis (BISAP) scores were also assessed. Additionally, defecation time and the total duration of hospitalization were compared between the two groups.

Results

Inflammatory markers declined in all groups by the third day post-admission, with the observation group exhibiting a significantly greater reduction compared to the control group (p < 0.05). Similarly, from the first day to the third day, both groups experienced a decrease in abdominal pain scores, CTSI, and BISAP scores, with the observation group showing a significantly more pronounced decrease in BISAP scores compared to the control group (p < 0.05). By the seventh day of admission, inflammatory markers continued to decline in all groups compared to the third day, except for TNF-α levels, and the observation group demonstrated a significantly greater decrease compared to the control group (p < 0.05). Abdominal pain scores, CTSI, and BISAP scores also decreased further in both groups compared to the third day, with the observation group again showing a significantly greater improvement than the control group (p < 0.05). Additionally, the observation group had a significantly shorter time to bowel movement resumption (38.23 ± 2.31 h vs. 43.43 ± 2.75 h, p = 0.013) and total hospital stay compared to the control group (10.97 ± 0.35 days vs. 13.40 ± 0.50 days, p < 0.001).

Conclusion

Early oral ingestion combined with probiotics can reduce the levels of inflammatory factors, improve abdominal pain symptoms, alleviate pancreatic edema and shorten defecation time and hospital stay in patients with severe acute pancreatitis.
Handgrip strength is independently associated with physical quality of life in patients undergoing maintenance hemodialysis: a cross-sectional study
Authors: Li Chunlei , Pan Xiangyou , Xu Shilin , Hu Jianguang , Zhong Xiaoshi , Wen Luona , Qiu Jingxian , Tan Rongshao
Published: December 2024

Objective

We aimed to identify the association between Health-related quality of life (HRQoL) and muscle strength in patients undergoing maintenance hemodialysis (MHD).

Methods

In this cross-sectional study from March 2021 to December 2021, 110 MHD patients with a mean age of 63.9 ± 13.0 years and a median dialysis vintage of 25.5 (12.0–52.3) months, were enrolled at a hemodialysis center in Guangzhou city, China. HRQoL was assessed using the Short Form 36 Health Survey (SF-36) and converted into the Physical Component Summary (PCS) and the Mental Component Summary (MCS). The groups were assigned according to the mean score of PCS and MCS, and those with higher PCS/MCS scores (high-PCS/MCS) were compared with those with lower PCS/MCS scores (low-PCS/MCS). Independent factors were evaluated using multivariate analysis. Muscle strength was estimated by handgrip strength (HGS).

Results

The mean HGS was 23.7 ± 9.60 kg in men and 14.3 ± 5.30 kg in women. Compared to the high-PCS group, the low-PCS group had older age, higher levels of creatinine, total cholesterol, high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6), and had lower HGS (all p < 0.05). After adjusting for confounding factors in different models, the five-model multivariate binary logistic regression analyses revealed that HGS was the only independent factor in PCS domain, but not in MCS.

Conclusion

HGS may be an independent factor of poor HRQoL in MHD patients, particularly in relation to physical health. The management of muscle strength may improve the HRQoL in MHD patients.

Clinical trial registration

The study was registered at https://www.chictr.org.cn/ as ChiCTR2100053790.
Obstacles and sustainability of enhanced recovery after surgery in pediatric laparoscopic pyeloplasty
Authors: Zhu Wenliang , Lai Huajian , He Ziqin , Zhang Yifei , Guo Qiang , Zhong Wenwen , Ye Lei , Qiu Jianguang , Wang Dejuan
Published: December 2024

Objectives

Previous studies on Enhanced Recovery After Surgery (ERAS) in pediatric Laparoscopic Pyeloplasty (LP) lacked clear control cases and discussed the obstacles in the implementation process. This article details the obstacles and lessons learned during the implementation of ERAS in patients with ureteropelvic junction obstruction (UPJO).

Methods

An ERAS protocol was implemented in the UPJO population undergoing LP, which included preoperative, intraoperative, and postoperative management. The clinical data of ERAS program Before Implementation (BI) and After Implementation (AI) were collected and analyzed retrospectively.

Results

A total of 107 patients (BI 46, AI 61) were enrolled. Compared with the BI group, the AI group had an earlier normal diet (19.83 h vs. 9.53 h, p < 0.001), ambulation (39.10 h vs. 12.70 h, p < 0.001), resumption of defecation (89.88 h vs. 27.90 h, p < 0.001), less need for additional analgesia (19.5% vs. 1.6%, p = 0.002) and shorter postoperative hospital stay (POS) (6.00 d vs. 1.91 d, p < 0.001) without increasing complications and readmission rates. Patients in the AI group had a median protocol score of 17 (IQR 16–18), and the compliance rate of the ERAS protocol was negatively correlated with the length of POS (R2 = 0.69, p < 0.001).

Conclusions

The application of ERAS in pediatric LP is feasible and sustainable, with the potential for even greater impact as compliance improves. Common barriers were uncertain start time of surgery, lack of knowledge of ERAS among pathway participants, and support from anesthesiologists. Pre-determining the start time of surgery, strengthening preoperative education and positive communication among team members can help to promote the full implementation of ERAS program.
Clinical characteristics and predictive indictors of macrolide-unresponsive Mycoplasma pneumoniae pneumonia in children: a retrospective study
Authors: Li Yun , Liu Yunwei , Chen Xinying , Xiao Xiaolan , Chen Yiting , Wang Lianyu , Jiang Wenwen , Yang Jinghua
Published: December 2024

Introduction

Macrolide-unresponsive Mycoplasma pneumoniae pneumonia (MUMPP) cases have been rapidly increasing. The primary reason for this increased incidence is the pathogen's acquisition of resistance through mutations in 23S rRNA genes. Due to the unfeasibility of testing for macrolide susceptibility at the time of admission, this study aimed to assess the clinical features of pediatric MUMPP, using insights from laboratory tests and patterns of chest radiographic resolution.

Material and methods

We conducted a retrospective review of 161 patients with M. pneumoniae pneumonia (MPP) between January 2023 and December 2023. These patients were categorized into two groups based on their responsiveness to macrolides: 72 patients were in the MUMPP group, and 89 patients were in the macrolide-sensitive Mycoplasma pneumoniae pneumonia (MSMP) group.

Results

MUMPP patients experienced a longer duration of fever and hospital stay. A higher proportion of MUMPP patients had shortness of breath, transcutaneous blood oxygen saturation (SpO2) lower than 94%, bilateral lobar infiltrates, lobar pneumonia and pleural effusion. The serum level of serum ferritin (SF), interleukin-6(IL-6), D-dimer, lactate dehydrogenase to albumin rate (LAR), and neutrophil to lymphocyte rate (NLR) were higher in MUMPP group.

Conclusions

Our findings revealed that patients with MUMPP exhibit more severe initial radiographic indicators and clinical course compared to those with MSMP. Therefore, it is crucial to promptly administer alternative therapeutic agents besides macrolides for the management of MUMPP.
Trabecular bone scores in children with osteogenesis imperfecta respond differently to bisphosphonate treatment depending on disease severity
Authors: Futagawa Natsuko , Hasegawa Kosei , Miyahara Hiroyuki , Tanaka Hiroyuki , Tsukahara Hirokazu
Published: December 2024

Introduction

Osteogenesis imperfecta (OI) is a congenital skeletal disorder characterized by bone fragility. Bisphosphonates (BISs) have become the mainstream treatment in children with OI. However, an optimal treatment protocol has not yet been established, while BIS treatment tends to be administered to normalize bone mineral density (BMD). Bone quality is an important component of bone strength. The trabecular bone score (TBS) is a quantitative measure of the microstructure that affects bone quality. This study investigated the TBS during BIS treatment in children with OI.

Materials and methods

Twenty-nine children with OI were enrolled and classified into two groups: mild (type 1) and moderate to severe (types 3 and 4). Dual-energy x-ray absorptiometry images were retrospectively analyzed for TBS calculation. The relationship between the areal BMD (aBMD), its Z-score, height-adjusted BMD (BMDHAZ) Z-score, TBS, and TBS Z-score with the treatment duration was assessed for each group.

Results

In the mild group, the aBMD, its Z-score, and BMDHAZ Z-score showed a significant positive correlation with treatment duration (r = 0.68, 0.68, 0.72, respectively, p < 0.01). The TBS Z-score tended to increase with treatment duration, albeit without reaching significance. In the moderate to severe group, the TBS Z-score showed a significant positive correlation with treatment duration (r = 0.48, p < 0.01), in contrast to the aBMD Z-score, which did not increase. Finally, the BMDHAZ Z-score only showed a weak positive correlation with treatment duration (r = 0.37, p < 0.01).

Conclusion

Because BIS affect the BMD and TBS differently based on the severity of OI, treatment goals may need to be stratified by disease severity.
Targeting cuproptosis with nano material: new way to enhancing the efficacy of immunotherapy in colorectal cancer
Authors: Liu Xiangdong , Zhang Wanqiu , Wei Shaozhong , Liang Xinjun , Luo Bo
Published: December 2024

Colorectal cancer has emerged as one of the predominant malignant tumors globally. Immunotherapy, as a novel therapeutic methodology, has opened up new possibilities for colorectal cancer patients. However, its actual clinical efficacy requires further enhancement. Copper, as an exceptionally crucial trace element, can influence various signaling pathways, gene expression, and biological metabolic processes in cells, thus playing a critical role in the pathogenesis of colorectal cancer. Recent studies have revealed that cuproptosis, a novel mode of cell death, holds promise to become a potential target to overcome resistance to colorectal cancer immunotherapy. This shows substantial potential in the combination treatment of colorectal cancer. Conveying copper into tumor cells via a nano-drug delivery system to induce cuproptosis of colorectal cancer cells could offer a potential strategy for eliminating drug-resistant colorectal cancer cells and vastly improving the efficacy of immunotherapy while ultimately destroy colorectal tumors. Moreover, combining the cuproptosis induction strategy with other anti-tumor approaches such as photothermal therapy, photodynamic therapy, and chemodynamic therapy could further enhance its therapeutic effect. This review aims to illuminate the practical significance of cuproptosis and cuproptosis-inducing nano-drugs in colorectal cancer immunotherapy, and scrutinize the current challenges and limitations of this methodology, thereby providing innovative thoughts and references for the advancement of cuproptosis-based colorectal cancer immunotherapy strategies.
Clinical predictors of treatment response to gabapentin in women with unexplained chronic pelvic pain
Authors: Coxon Lydia , Amer Maryam , Daniels Jane , Doust Ann M. , Mackenzie Scott C. , Horne Andrew W. , Vincent Katy
Published: December 2024

Introduction

Chronic pelvic pain affects up to 24% of women worldwide and for up to 55% of these there is no associated pathology. Despite this there are no established treatments in this cohort. This is a secondary analysis of a randomised-controlled trial (GaPP2) to explore if there are measures which enable us to predict treatment outcome.

Methods

GaPP2 recruited women with chronic pelvic pain and no identified pathology and compared the response to gabapentin and placebo. This analysis used variables collected at baseline including validated questionnaires. Binary logistic regression was used to create models to explore whether baseline variables predicted treatment response. Treatment response was determined using 30% reduction in average pain intensity, 30% reduction in worst pain intensity and the Patient Global Impression of Change (‘marked’ or ‘very marked’ improvement) individually. We also explored whether baseline variables predicted the occurrence of side-effects (dizziness, visual disturbances and drowsiness).

Results

Using the Patient Global Impression of Change questionnaire, we found a significant binary logistic regression (p = 0.029, explaining 31% of the variance), with those with lower worst pain intensity (odds ratio (OR) of 0.393, 95% CI [0.217, 0.712]), lower bladder symptom score (OR = 0.788, CI [0.628, 0.989]), and higher mental component quality of life score (OR = 0.911, CI [0.840, 0.988]), more likely to have ‘marked’ or ‘very marked’ improvement when treated with gabapentin. We could not identify predictors of experiencing side-effects to gabapentin. However, we did find predictors of these in the placebo group (binary logistic regression (p = 0.009) and explained 33% of the variance). Worse mental health (OR = 1.247, CI [1.019, 1.525]) and lower baseline pain interference (OR = 0.687, CI [0.483, 0.978]) were associated with having side effects, whilst the use of hormones reduced the risk of experiencing side effects (OR = 0.239, CI [0.084, 0.676]).

Discussion

Researchers and clinicians are increasingly aware of the importance of personalised medicine and treatment decisions being driven by knowledge of what treatments work for whom. Our data suggests an important role of the Patient Global Impression of Change in clinical trials as it may better reflect balance between symptoms reduction and side-effects and therefore be more useful in clinician-patients joint decision making.
Cuticular wax in wheat: biosynthesis, genetics, and the stress response
Authors: Tian Ruiyang , Liu Wendi , Wang Yuhai , Wang Wenqiang
Published: December 2024

All terrestrial plants possess a hydrophobic cuticle in the outermost layer of their aerial organs that is composed of cutin and wax. The cuticle serves as the first barrier between the plant and the surrounding environment and plays a key role in the resistance of plants to abiotic and biotic stressors. Additionally, they are closely associated with plant growth and development. Cuticular wax has attracted considerable attention as the main mediator of cuticular functions. In this review, we summarize the advances in the research investigating wheat cuticular wax, focusing on three aspects that include biosynthesis, genetics, and stress responses. Additionally, we discuss the applications of cuticular wax in wheat breeding.
Toward characterization of perceptual specialization for faces in Multiracial contexts
Authors: Pickron Charisse B. , Kutlu Ethan
Published: December 2024

This conceptual analysis focuses on opportunities to advance research and current hypotheses of perceptual development by examining what is presently known and unknown about perceptual specialization in a Multiracial context during the first year of life. The impact of being raised in a Multiracial family or community is discussed to further characterize the development of perceptual expertise for faces and languages. Historical and present-day challenges faced by researchers in defining what race is, identifying Multiracial individuals or contexts, and how to study perceptual and cognitive processes in this population are discussed. We propose to leverage current data from developmental Multilingual populations as a guide for future research questions and hypotheses characterizing perceptual specialization based on face race for Multiracial/Multiethnic individuals and contexts. Variability of input and the pattern of specialization are two factors identified from the developmental Multilingual literature that are likely useful for studying Multiracial contexts and development. Several methodological considerations are proposed in hopes of facilitating research questions and practices that are reflective of and informed by the diversity of experiences and social complexities within Multiracial populations.
Family resilience and social support as mediators of caregiver burden and capacity in stroke caregivers: a cross-sectional study
Authors: Xu Qihang , Ma Jingjing , Zhang Yiqing , Gan Jiehua
Published: December 2024

Introduction

Caring for stroke survivors poses significant challenges to survivors and caregivers; understanding these relationships can inform targeted interventions and support systems.

Aim

This study investigates the influencing factors of caregiver burden and the potential mediating roles of family resilience and perceived social support between caregiver burden and caregiver capacity.

Design

This is a cross-sectional study.

Methods

The participants in this study included 462 stroke survivors and their primary caregivers from Ningbo Lihuili Hospital in Zhejiang Province, China. Primary caregivers completed several assessments, including the Shortened Chinese Version of the Family Resilience Assessment Scale (FRAS), the Perceived Social Support Scale (PSSS), the Zarit Caregiver Burden Interview (ZCBI), and the Family Caregiver Task Inventory (FCTI). The ZCBI was used to evaluate caregiver burden, while the activities of daily living (ADL) were assessed for stroke survivors to measure their actual level of dependence. The mediating effect of family resilience was estimated using the bootstrap method through Jamovi version 2.3.0 with the mediation plug-in, while controlling for sociodemographic variables.

Results

The results showed that caregiver burden was influenced by stroke survivors’ level of dependence on activities of daily living (ADL), caregiver education level, caregiver health status, and average daily care time. The family resilience mediated the relationship between caregiver burden and caregiver capacity (b = 0.141; 95% confidence interval: 0.091 to 0.176). Additionally, perceived social support mediated the relationship between caregiver burden and caregiver capacity (b = 0.080; 95% confidence interval: 0.041 to 0.110).

Conclusion

These findings indicate that enhancing family resilience and perceived social support can be strategies for alleviating caregiver burden. Clinical practitioners should actively assess the family resilience and social support of stroke survivors, and implement interventions that promote resilience and strengthen social support, thereby reducing caregiver burden and improving the health outcomes of stroke survivors.
Psychotic relapse prediction via biomarker monitoring: a systematic review
Authors: Smyrnis Alexandros , Theleritis Christos , Ferentinos Panagiotis , Smyrnis Nikolaos
Published: December 2024

Background

Associating temporal variation of biomarkers with the onset of psychotic relapse could help demystify the pathogenesis of psychosis as a pathological brain state, while allowing for timely intervention, thus ameliorating clinical outcome. In this systematic review, we evaluated the predictive accuracy of a broad spectrum of biomarkers for psychotic relapse. We also underline methodological concerns, focusing on the value of prospective studies for relapse onset estimation.

Methods

Following the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines, a list of search strings related to biomarkers and relapse was assimilated and run against the PubMed and Scopus databases, yielding a total of 808 unique records. After exclusion of studies related to the distinction of patients from controls or treatment effects, the 42 remaining studies were divided into 5 groups, based on the type of biomarker used as a predictor: the genetic biomarker subgroup (n = 4, or 9%), the blood-based biomarker subgroup (n = 15, or 36%), the neuroimaging biomarker subgroup (n = 10, or 24%), the cognitive-behavioral biomarker subgroup (n = 5, or 12%) and the wearables biomarker subgroup (n = 8, or 19%).

Results

In the first 4 groups, several factors were found to correlate with the state of relapse, such as the genetic risk profile, Interleukin-6, Vitamin D or panels consisting of multiple markers (blood-based), ventricular volume, grey matter volume in the right hippocampus, various functional connectivity metrics (neuroimaging), working memory and executive function (cognition). In the wearables group, machine learning models were trained based on features such as heart rate, acceleration, and geolocation, which were measured continuously. While the achieved predictive accuracy differed compared to chance, its power was moderate (max reported AUC = 0.77).

Discussion

The first 4 groups revealed risk factors, but cross-sectional designs or sparse sampling in prospective studies did not allow for relapse onset estimations. Studies involving wearables provide more concrete predictions of relapse but utilized markers such as geolocation do not advance pathophysiological understanding. A combination of the two approaches is warranted to fully understand and predict relapse.
Prevalence of mental disorders and their associations with age at diagnosis and time since diagnosis of nasopharyngeal cancer
Authors: Wang Wen-Xuan , Wu Yi-Shan , Qi Li-Ping , Wu Anise M. S. , Zhu Ying-Ying , Gong Wei-Jie , Guo Shan-Shan , Hua Yi-Jun , Luo Dong-Hua , Chen Qiu-Yan , Xiang Yan-Qun , Zhang Jin-Xin , Mai Hai-Qiang , Li Ji-Bin
Published: December 2024

Background

Despite advancements in cancer treatment, understanding the long-term mental health implications for nasopharyngeal carcinoma (NPC) survivors remains an underexplored area. This study aims to examine the prevalence of mental disorders and their correlations with age at diagnosis and time since diagnosis among NPC survivors.

Methods

A total of 1872 NPC patients were surveyed from September 2020 to June 2021 in this cross-sectional survey. Logistic regression models were used to analyze the associations of age at diagnosis and time since NPC diagnosis with the risk of mental disorders. Additionally, the potential nonlinear trend between these factors was examined using restricted cubic splines. Analyses were conducted both overall and stratified by gender. Gender interaction was also examined.

Results

The prevalences of depression, anxiety, and sleep disorders were 32.4, 33.2, and 61.5%, respectively. Age at NPC diagnosis was significantly associated with an elevated risk of depression (adjusted OR (aOR): 1.75 for 30–39 years old; 2.33 for 50–59 years old; 2.59 for ≥60 years old) and sleep disorders (aOR: 2.41 for 40–49 years old; 1.95 for 50–59 years old; 2.26, for ≥60 years old), compared to patients diagnosed with NPC at age < 30 years. Conversely, the risk of depression, anxiety, and sleep disorders exhibited negative associations with the time since diagnosis, compared to patients <3 months. Notably, significant nonlinear associations were observed between time since diagnosis and the risk of depression, anxiety, and sleep disorders, which showed an initial increase, with the highest risk occurring at approximately 3.0 (ORmax: 2.7), 1.5 (ORmax: 2.1), and 4.0 (ORmax: 1.9) months since NPC diagnosis, followed by a gradual recovery to a lower risk level at around 12 months. No gender interactions were observed.

Conclusion

The prevalence of mental disorders is notable among NPC survivors, showing a positive correlation with age at diagnosis while displaying a negative correlation with time since diagnosis, thus indicating the need for psychological support, especially within the initial several months following NPC diagnosis.
Ovule and seed development of crop plants in response to climate change
Authors: Erfatpour Mohammad , MacLean Dustin , Lahlali Rachid , Jiang Yunfei
Published: December 2024

The ovule is a plant structure that upon fertilization, transforms into a seed. Successful fertilization is required for optimum crop productivity and is strongly affected by environmental conditions including temperature and precipitation. Climate change refers to sustained changes in global or regional climate patterns over an extended period, typically decades to millions of years. These shifts can result from natural processes like volcanic eruptions and solar radiation fluctuations, but in recent times, human activities—especially the burning of fossil fuels, deforestation, and industrial emissions—have accelerated the pace and scale of climate change. Human-induced climate change impacts the agricultural sector mainly through global warming and altering weather patterns, both of which create conditions that challenge agricultural production and food security. With food demand projected to sharply increase by 2050, urgent action is needed to prevent the worst impacts of climate change on food security and allow time for agricultural production systems to adapt and become more resilient. Gaining insights into the female reproductive part of the flower and seed development under extreme environmental conditions is important to oversee plant evolution, agricultural productivity, and food security in the face of climate change. This review summarizes the current knowledge on plant reproductive development and the effects of temperature and water stress, soil salinity, elevated carbon dioxide, and ozone pollution on the female reproductive structure and development across grain legumes, cereal, oilseed, and horticultural crops. It identifies gaps in existing studies for potential future research and suggests suitable mitigation strategies for sustaining crop productivity in a changing climate.
Choosing the proper path: outcomes of subxiphoid vs. lateral intercostal approaches in the resection of anterior mediastinal masses
Authors: Leng Xuechun , Chen Mengzou , Zhang Yang , Gao Jian , You Zhenbing , Hu Zhongwu
Published: December 2024

Background

While the subxiphoid approach (SA) in thoracoscopic thymectomy offers benefits in terms of fat removal and pain reduction, it remains unclear which patients with anterior mediastinal masses benefit most from the subxiphoid vs. the lateral intercostal approach (LA).

Methods

This retrospective study analyzed patients treated for anterior mediastinal masses at our center from January 2019 to December 2023. Patients were categorized into two groups based on the surgical approach: SA (35 cases) and LA (56 cases). Demographic data, clinical characteristics, perioperative metrics, and short-term outcomes were compared.

Results

Ninety-one patients were included, with diagnoses including thymic cysts (43), thymomas types A, AB, and B1 (24), B2 thymomas (18), thymic carcinoma (6).No significant differences were found between the groups in terms of gender, age, tumor size, body mass index, conversion to sternotomy, or blood loss. The LA group, however, experienced shorter surgical durations (P < 0.001), less drainage (P = 0.021), shorter hospital stays (P < 0.001), and lower hospitalization costs (P = 0.024). Pain scores on the visual analogue scale were similar between groups on the day of surgery and the first postoperative day.

Conclusion

The findings suggest that the lateral intercostal approach is preferable for patients with thymic cysts and Masaoka stage I–II thymomas without myasthenia gravis due to its efficiency and cost-effectiveness.
Platelet rich fibrin three-layer reconstruction of the sellar floor after endoscopic endonasal transsphenoidal approach: technical note and initial experience
Authors: Shah Mukesch Johannes , Argiti Katerina , Nakagawa Julia M. , Stathi Angeliki , Schönen Emilia , Strahnen Daniel , Joseph Kevin , Straehle Jakob , Neidert Nicolas , Beck Jürgen , Vasilikos Ioannis
Published: December 2024

Background

Cerebrospinal fluid (CSF) leakage frequently complicates endoscopic endonasal transsphenoidal pituitary resections, despite the use of lumbar drains, nasoseptal flaps, or commercial dura sealants. Managing this complication often requires revision surgery and increases the risk of infection. Platelet-rich fibrin (PRF), an affordable autologous biomaterial derived from the patient's blood through short, angulated centrifugation, contains growth factors and leukocytes embedded in a fibrin matrix. PRF exhibits regenerative properties in various surgical disciplines. This study assesses a three-layer sellar reconstruction method employing solid membranous (s-PRF) and high-viscosity injectable (i-PRF) forms of PRF.

Materials and methods

We present our initial experience on a series of 22 patients with pituitary macroadenomas. For all patients, an endoscopic transnasal transsphenoidal approach was selected. Following the resection of the pathology, sellar reconstruction was accomplished using a three-layer orthobiologic technique. A membranous s-PRF was utilized as an inlay inside the opened sellar floor, followed by a layer of injectable i-PRF finally covered with another s-PRF membrane over the top to the sellar corridor.

Results

In all cases the implementation of the proposed three-layer PRF reconstruction strategy was feasible and safe. During the 12-month follow-up period there were no adverse effects reported associated with the PRF application. 77% (17/22) of the patients demonstrated intraoperatively a cerebrospinal fluid (CSF) leak (Esposito Grade 1–3). In total, the proposed PRF reconstruction effectively prevented postoperative CSF leaks in 95% of the patients and in 94% of those with an Esposito Grade 1–3. One of the two patients with intraoperative Esposito Grade 3 developed a CSF leak on the first postoperative day, which was successfully managed with a lumbar drain for 5 days.

Conclusion

Sellar reconstruction after endoscopic endonasal transsphenoidal resection of pituitary adenomas with PRF is feasible and safe. The three layer PRF augmentation is a novel technique to prevent CSF-leakage.
Proinflammatory cytokines interleukin-18 and interleukin-6 mediate anorexia induction by trichothecene deoxynivalenol and its congeners
Authors: Zhou Chuang , Qin Zihui , Zhang Huayue , Xiao Huiping , Zhang Hua
Published: December 2024

As the common foodborne mycotoxins with the highest pollution rate, deoxynivalenol (DON, also named “vomitoxin”) can harm the health of humans and animals by causing anorectic response. It has four congeners: 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), nivalenol (NIV), and fusarenon X (FX). These five mycotoxins have been associated with the detrimental effect on food intake. However, its underlying mechanism of anorexia remains unclear. The goal of this research was to compare the anorectic responses to these five mycotoxins and relate these effects to proinflammatory cytokines interleukin-18 (IL-18) and interleukin-6 (IL-6) following intraperitoneal (IP) and oral exposure to a common dose at 2.5 mg/kg BW in mice. Plasma IL-18 and IL-6 were elevated within 1–2 h and returned to basal levels at 6 h after exposure to DON, 3-ADON and 15-ADON. FX promoted IL-18 expression at 6 h. Whereas, FX only promoted IL-6 at 6 h. When NIV was injected intraperitoneally, IL-18 started to rise at 1 h and peaked at 6 h. Whereas, NIV only promoted IL-18 at 2 h following oral exposure. IP exposure to NIV induced an increase in IL-6 that occurred only at 2 h. No effect on IL-6 when exposed orally to NIV. In conclusion, the data indicate that IL-18 and IL-6 play critical roles in anorectic response induced by DON and its four congeners 3-ADON, 15-ADON, NIV, FX.
A Novel Optimization Algorithm Inspired by Egyptian Stray Dogs for Solving Multi-Objective Optimal Power Flow Problems
Authors: ElMessmary Mohamed H. , Diab Hatem Y. , Abdelsalam Mahmoud , Moussa Mona F.
Published: December 2024

One of the most important issues that can significantly affect the electric power network’s ability to operate sustainably is the optimal power flow (OPF) problem. It involves reaching the most efficient operating conditions for the electrical networks while maintaining reliability and systems constraints. Solving the OPF problem in transmission networks lowers three critical expenses: operation costs, transmission losses, and voltage drops. The OPF is characterized by the nonlinearity and nonconvexity behavior due to the power flow equations, which define the relationship between power generation, load demand, and network component physical constraints. The solution space for OPF is massive and multimodal, making optimization a challenging concern that calls for advanced mathematics and computational methods. This paper introduces an innovative metaheuristic algorithm, the Egyptian Stray Dog Optimization (ESDO), inspired by the behavior of Egyptian stray dogs and used for solving both single and multi-objective optimal power flow problems concerning the transmission networks. The proposed technique is compared with the particle swarm optimization (PSO), multi-verse optimization (MVO), grasshopper optimization (GOA), and Harris hawk optimization (HHO) and hippopotamus optimization (HO) algorithms through MATLAB simulations by applying them to the IEEE 30-bus system under various operational circumstances. The results obtained indicate that, in comparison to other used algorithms, the suggested technique gives a significantly enhanced performance in solving the OPF problem.
From Folklore to Conspiracy Beliefs: A Gramscian Approach to Conspiracy Theory Studies
Authors: Pozzoni Maria Chiara , Quattromini Giuseppe
Published: December 2024

This paper applies Antonio Gramsci’s theory of folklore—defined as the cultural expressions of subaltern groups reflecting their lived experiences of subalternity—to contemporary conspiracy beliefs, arguing that these beliefs function as a form of what he called “modern folklore”. Drawing on Gramsci’s insights into hegemony, it examines how subaltern beliefs emerge as both reflections of and responses to sociocultural conditions. The paper demonstrates that conspiracy mentality, akin to Gramscian folklore, inadequately encapsulates the issues and aspirations of those feeling marginalised and not represented within hegemonic systems. It outlines how distorted elements of modern scientific and political thought are integrated into folklore, resulting in inconsistent and fragmented worldviews. Key topics include the role of commercial literature in shaping subaltern consciousness and the political implications of conspiracy beliefs, particularly how they are utilised by reactionary movements to further their agendas. The analysis concludes with two case studies: one from Gramsci’s writings and another on contemporary conspiracy beliefs related to COVID-19, illustrating how these examples exemplify modern folklore. This approach offers a critical framework for understanding the social, cultural, and political origins and functions of conspiracy beliefs, highlighting the relevance of Gramsci’s thought to conspiracy theory studies.
The Effect of Lactiplantibacillus plantarum and Lacticaseiba-cillus Rhamnosus Strains on the Reduction of Hexachlorobenzene Residues in Fermented Goat Milk During Refrigerated Storage
Authors: Witczak Agata , Dmytrów Izabela , Mituniewicz-Małek Anna
Published: December 2024

Hexachlorobenzene (HCB) is a persistent organic pollutant (POP) commonly detected in milk and dairy products. These compounds pose a serious threat to the health of consumers due to their considerable bioaccumulation potential, high stability, and toxicity. (2) Methods: The study evaluated the potential of Lactiplantibacillus plantarum and Lacticaseibacillus rhamnosus probiotic cultures to reduce HCB residues in fermented goat milk beverages during 21-day refrigerated storage. HCB content was determined by gas chromatography coupled with mass spectrometry (GC/MS). (3) Results: A strong negative correlation was found between HCB concentration in fermented milk and storage time. After 21 days, a 75–78% reduction in HCB content was observed, with L. plantarum showing greater efficiency in reducing hexachlorobenzene levels than L. rhamnosus. (4) Conclusions: The use of probiotic cultures contributed to a significant reduction in the HCB content of fermented goat milk. Our findings support the hypothesis that the lactic acid bacteria Lactiplantibacillus plantarum and Lacticaseibacillus rhamnosus can lower hexachlorobenzene levels in fermented products
Comparative Efficacy of Botryocladia leptopoda Extracts in Scar Inhibition and Skin Regeneration: A Study on UV Protection, Collagen Synthesis, and Fibroblast Proliferation
Authors: Hsieh Chen-Che , Yi Tsung-Kai , Kao Yi-Feng , Lin Shin-Ping , Tu Ming-Chieh , Chou Yu-Chieh , Lu Jheng-Jhe , Chai Huey-Jine , Cheng Kuan-Chen
Published: December 2024

Botryocladia leptopoda is a red macroalga known for its bioactive compounds with antioxidant, anti-inflammatory, and skin-regenerative properties. The study aimed to examine their effects on UV protection, collagen synthesis, fibroblast proliferation, and pigmentation modulation. Bioactive compounds were extracted using two solvents, producing ethanol extract (FE) and alkaline extracts (AE). Methods involved characterizing extracts using mass spectrometry and assessing their effects on human fibroblasts under UVB-induced damage. UV absorbance, ROS production, and collagen synthesis were evaluated. The FE extract, which comprised 4-hydroxyquinoline, phytosphingosine, and docosapentaenoic acid, reinstated procollagen type I synthesis to 113% of baseline levels and reduced TGF-β1-mediated fibroblast proliferation to 87.78%. FE also suppressed Smad2 and α-SMA by 71% and 68%, respectively, indicating modulation of fibrosis-associated pathways. AE, containing 4-hydroxyquinoline and phenylalanine betaine, demonstrated dose-responsive cellular repair, reducing fibroblast proliferation to 97.86% and collagen Type I expression by 73% at 1000 μg/mL. Both extracts decreased ROS production, with FE and AE reducing levels by 21.4% and 19.7%, respectively, under UVB-induced oxidative stress. FE showed superior scar inhibition, while AE excelled in skin regeneration and pigmentation management.