bluuebunny/crossref_metadata_2025 huggingface dataset:
Phenotypic response to soil compaction varies among genotypes and correlates with plant size in sorghum
Authors: Correa José , Postma Johannes A. , Wojciechowski Tobias
Published: January 2022

Aims

Soil compaction is a major yield-reducing factor worldwide and imposes physico-chemical constraints to plant growth and development. Facing limitations, roots can adapt and compensate for loss of functioning through their plasticity. Being primarily a belowground challenge, tolerance to soil compaction needs to be associated with root phenotype and plasticity. It is therefore of importance to distinguish between size-related apparent and size-independent adaptive plasticity. We determined the above- and belowground plasticity of sorghum genotypes varying in overall plant size.

Methods

We quantified plasticity as the degree response (adaptive and apparent plasticity) to soil compaction and conducted two experiments with sorghum and two soil density levels (1.4 and 1.8 Mg m−3). First, we quantified the shoot biomass plasticity of 28 sorghum genotypes. Second, we studied the root plasticity of six genotypes varying in shoot size and tolerance to soil compaction.

Results

Plasticity was correlated with plant biomass with larger genotypes responding earlier and more intensely. Soil compaction affected roots more than shoots and plasticity was expressed foremost in nodal root number and fine root length. Impeded plants produced 35 and 47% less root mass and length, respectively.

Conclusions

Plasticity to soil compaction varies among genotypes, but less-sensitive lines are in general smaller-sized genotypes. The association between tolerance and plant biomass may pose challenges to crop production; however, vigorous genotypes with unresponsive shoots to soil compaction do exist. Maintaining shoot growth relatively stable while the root modifies its structure can be an important adaptation mechanism to soil compaction.
Bridging the Knowledge Gap in Collaborative Research—in Dialogues We Trust
Authors: Melander Anders , Mullern Tomas , Anderssson David , Elgh Fredrik , Löfving Malin
Published: January 2022

By building upon the prior work exploring the nature of practicing and knowing in collaborative research (CR), this article argues that focusing on how trust evolves in collaborative dialogue could enhance the learning potential in CR projects. Drawing from 42 workshops within a CR project, we analyze how dialogue and learning practices develop trust. We use the dialogical framework developed by Walton and Krabbe (1995) to identify and classify 107 dialogues. From our data, we identify three distinct dialogical patterns (educating, inquiring and practicing). These three dialogical patterns are related to four learning practices that are conceptualized as knowledge sharing, knowledge gapping, knowledge bettering and knowledge speculating. Combined, these dialogical patterns and learning practices develop collaborative trust in CR projects. We propose that these results represent an emerging conceptual language that addresses the development of trust in managing CR projects. This conceptual language can both improve managerial practice in the CR context and inspire future theory building.
Hydrogen Isotopes Permeation in Clean or Unoxidized FeCrAl Alloys: A Review
Authors: Garud Yogendra S. , Hoffman Andrew K. , Rebak Raul B.
Published: January 2022

The US Department of Energy is working with fuel vendors to develop accident tolerant fuels (ATF) for the current fleet of light water reactors (LWRs). The ATF should be more resilient to loss of coolant accident scenarios and help extending the life of the operating LWRs. One of the proposed ATF concepts is to use iron-chromium-aluminum (FeCrAl) alloys for the cladding of the fuel. A concern in using ferritic FeCrAl is that this type of cladding may result in an increase in the concentration of tritium in the coolant. The objective of the current critical review is to collect and assess information from the literature regarding diffusion or permeation of hydrogen (H) and its isotopes deuterium (D) and Tritium (T) across industrial alloys (including FeCrAl) used or intended for the nuclear industry. Over a hundred years of data reviewed shows that the solubility of hydrogen in ferritic alloys is lower than in austenitic alloys but hydrogen permeates faster through a ferritic material than through austenitic materials. The tritium permeation rates in FeCrAl alloys are between those in austenitic stainless steels and in ferritic FeCr steels. The activation energy for hydrogen permeation is approximately 30 pct higher in the austenitic alloys compared with the ferritic (typically ∼ 50 kJ/mol in ferritic vs. ∼ 65 kJ/mol in the austenitic). None of the major elements in FeCrAl alloys react with hydrogen to form detrimental hydride phases. The effect of surface oxides on FeCrAl delaying hydrogen entrance into FeCrAl alloy is not part of this review.
Prevalence of Elevated Liver Stiffness Among Potential Candidates for Bariatric Surgery in the United States
Authors: Ciardullo Stefano , Pizzi Mattia , Pizzi Pietro , Oltolini Alice , Muraca Emanuele , Perseghin Gianluca
Published: January 2022

Purpose

Obesity represents a well-known risk factor for metabolic-dysfunction associated fatty liver disease (MAFLD) and its progression towards cirrhosis. The aim of this study is to estimate the proportion of potential candidates to a bariatric surgery intervention that has an elevated liver stiffness on vibration-controlled transient elastography (VCTE).

Materials and Methods

This is a cross-sectional study performed using data obtained during the 2017–2018 cycle of the National Health and Nutrition Examination Survey. Potential candidates for a bariatric surgery intervention from the general US population were identified by applying criteria from international guidelines. All included participants were evaluated by VCTE. A controlled attenuation parameter (CAP) value ≥ 288 dB/m was considered indicative of steatosis while liver stiffness measurement (LSM) was considered elevated if ≥ 9.7 kPa. Multivariable logistic regression models were fitted to identify independent predictors of both outcomes.

Results

A total of 434 participants were included (mean age 42.9 ± 0.6 years; 54.4% women). Among them, 76.7% (95% CI 71.7–81.0) had steatosis, while 23.1% (95% CI 17.8–29.3) had an elevated LSM. Male sex, older age, γ-glutamyltranspeptidase levels, and body mass index (BMI) were independent predictors of steatosis, while BMI was the only independent predictor of elevated LSM. Non-Hispanic black participants were protected from both outcomes, while other ethnicities were not.

Conclusion

The prevalence of elevated LSM is high in potential candidates for a bariatric surgery intervention. Accurate screening for occult advanced liver disease might be indicated in this patient population.

Graphical abstract
Long Non-coding Antisense RNA DDIT4-AS1 Regulates Meningitic Escherichia coli-Induced Neuroinflammation by Promoting DDIT4 mRNA Stability
Authors: Yang Bo , Xu Bojie , Yang Ruicheng , Fu Jiyang , Li Liang , Huo Dong , Chen Jiaqi , Yang Xiaopei , Tan Chen , Chen Huanchun , Wang Xiangru
Published: January 2022

Our previous studies have shown that meningitic Escherichia coli can colonize the brain and cause neuroinflammation. Controlling the balance of inflammatory responses in the host central nervous system is particularly vital. Emerging evidence has shown the important regulatory roles of long non-coding RNAs (lncRNAs) in a wide range of biological and pathological processes. However, whether lncRNAs participate in the regulation of meningitic E. coli-mediated neuroinflammation remains unknown. In the present study, we characterized a cytoplasm-enriched antisense lncRNA DDIT4-AS1, which showed similar concordant expression patterns with its parental mRNA DDIT4 upon E. coli infection. DDIT4-AS1 modulated DDIT4 expression at both mRNA and protein levels. Mechanistically, DDIT4-AS1 promoted the stability of DDIT4 mRNA through RNA duplex formation. DDIT4-AS1 knockdown and DDIT4 knockout both attenuated E. coli-induced NF-κB signaling as well as pro-inflammatory cytokines expression, and DDIT4-AS1 regulated the inflammatory response by targeting DDIT4. In summary, our results show that DDIT4-AS1 promotes E. coli-induced neuroinflammatory responses by enhancing the stability of DDIT4 mRNA through RNA duplex formation, providing potential nucleic acid targets for new therapeutic interventions in the treatment of bacterial meningitis.
The Effect of Sleep Deprivation and Subsequent Recovery Period on the Synaptic Proteome of Rat Cerebral Cortex
Authors: Gulyássy Péter , Todorov-Völgyi Katalin , Tóth Vilmos , Györffy Balázs A. , Puska Gina , Simor Attila , Juhász Gábor , Drahos László , Kékesi Katalin Adrienna
Published: January 2022

Sleep deprivation (SD) is commonplace in the modern way of life and has a substantial social, medical, and human cost. Sleep deprivation induces cognitive impairment such as loss of executive attention, working memory decline, poor emotion regulation, increased reaction times, and higher cognitive functions are particularly vulnerable to sleep loss. Furthermore, SD is associated with obesity, diabetes, cardiovascular diseases, cancer, and a vast majority of psychiatric and neurodegenerative disorders are accompanied by sleep disturbances. Despite the widespread scientific interest in the effect of sleep loss on synaptic function, there is a lack of investigation focusing on synaptic transmission on the proteome level. In the present study, we report the effects of SD and recovery period (RP) on the cortical synaptic proteome in rats. Synaptosomes were isolated after 8 h of SD performed by gentle handling and after 16 h of RP. The purity of synaptosome fraction was validated with western blot and electron microscopy, and the protein abundance alterations were analyzed by mass spectrometry. We observed that SD and RP have a wide impact on neurotransmitter-related proteins at both the presynaptic and postsynaptic membranes. The abundance of synaptic proteins has changed to a greater extent in consequence of SD than during RP: we identified 78 proteins with altered abundance after SD and 39 proteins after the course of RP. Levels of most of the altered proteins were upregulated during SD, while RP showed the opposite tendency, and three proteins (Gabbr1, Anks1b, and Decr1) showed abundance changes with opposite direction after SD and RP. The functional cluster analysis revealed that a majority of the altered proteins is related to signal transduction and regulation, synaptic transmission and synaptic assembly, protein and ion transport, and lipid and fatty acid metabolism, while the interaction network analysis revealed several connections between the significantly altered proteins and the molecular processes of synaptic plasticity or sleep. Our proteomic data implies suppression of SNARE-mediated synaptic vesicle exocytosis and impaired endocytic processes after sleep deprivation. Both SD and RP altered GABA neurotransmission and affected protein synthesis, several regulatory processes and signaling pathways, energy homeostatic processes, and metabolic pathways.
Is a Wizard-of-Oz Required for Robot-Led Conversation Practice in a Second Language?
Authors: Engwall Olov , Lopes José , Cumbal Ronald
Published: January 2022

The large majority of previous work on human-robot conversations in a second language has been performed with a human wizard-of-Oz. The reasons are that automatic speech recognition of non-native conversational speech is considered to be unreliable and that the dialogue management task of selecting robot utterances that are adequate at a given turn is complex in social conversations. This study therefore investigates if robot-led conversation practice in a second language with pairs of adult learners could potentially be managed by an autonomous robot. We first investigate how correct and understandable transcriptions of second language learner utterances are when made by a state-of-the-art speech recogniser. We find both a relatively high word error rate (41%) and that a substantial share (42%) of the utterances are judged to be incomprehensible or only partially understandable by a human reader. We then evaluate how adequate the robot utterance selection is, when performed manually based on the speech recognition transcriptions or autonomously using (a) predefined sequences of robot utterances, (b) a general state-of-the-art language model that selects utterances based on learner input or the preceding robot utterance, or (c) a custom-made statistical method that is trained on observations of the wizard’s choices in previous conversations. It is shown that adequate or at least acceptable robot utterances are selected by the human wizard in most cases (96%), even though the ASR transcriptions have a high word error rate. Further, the custom-made statistical method performs as well as manual selection of robot utterances based on ASR transcriptions. It was also found that the interaction strategy that the robot employed, which differed regarding how much the robot maintained the initiative in the conversation and if the focus of the conversation was on the robot or the learners, had marginal effects on the word error rate and understandability of the transcriptions but larger effects on the adequateness of the utterance selection. Autonomous robot-led conversations may hence work better with some robot interaction strategies.
Die Relevanz von Sozialkapitalindikatoren für die Mitgliederbindung in Zeiten von Corona
Authors: Burrmann Ulrike , Sielschott Stephan , Braun Sebastian
Published: January 2022

Bereits vor der Corona-Pandemie berichteten immer mehr Sportvereine von zurückgehenden Mitgliederzahlen, episodischen Engagements und Schwierigkeiten bei der Gewinnung und Bindung von freiwillig Engagierten. Angesichts der komplexen Einschränkungen der Sportvereins- und geselligen Aktivitäten während der Corona-Pandemie stellt sich die Frage, wie diese außergewöhnliche soziale Situation die Mitgliederbindung in Vereinen beeinflusst hat und welche Bedeutung dem Sozialkapital zukommt. Der vorliegende Beitrag, in dem die Mitgliederbindung nach der Corona-Pandemie abgeschätzt werden soll, greift eine Forschungslücke auf, wobei v. a. die Relevanz von verschiedenen Sozialkapitalindikatoren betrachtet wird. Basis der empirischen Analysen bildet eine repräsentative Bevölkerungsbefragung, die Ende 2020/Anfang 2021 durchgeführt wurde. Die Mitgliederbindung der Sportvereinsmitglieder ist nach wie vor recht hoch. Sozialkapitalindikatoren, die sich eng auf den Sportverein beziehen, erklären wenig zur Vorhersage der Mitgliederbindung. Neben den im Verein wahrgenommenen Reziprozitätsnormen erhöhen Hilfsbereitschaft und Ingroup-Vertrauen die Bindung an den Verein, während Geselligkeitsorientierung und Outgroup-Vertrauen die Wahrscheinlichkeit verringern, auch nach der Pandemie noch Mitglied im Verein zu sein. Unter Einbeziehung aller Prädiktoren erhöht sich die Modellgüte auf knapp 26 %. Neben wenigen soziodemographischen Merkmalen tragen v. a. mitgliedschaftsbezogene Merkmale (z. B. Krisenmanagement des Vereins) zur Varianzaufklärung bei. Hilfsbereitschaft, Outgroup-Vertrauen und tendenziell auch Geselligkeitsorientierung stellen im Gesamtmodell die einzigen bedeutsamen Sozialkapitalindikatoren dar, wenngleich sie mit beachtlichen Gewichten zur Varianzaufklärung beitragen.
Fluid Resonance Between Twin Floating Barges with Roll Motion Under Wave Action
Authors: Li Shu , Teng Bin
Published: January 2022

The wave-induced fluid resonance between twin side-by-side rectangular barges coupled with the roll motion of the twin barges is investigated by both numerical simulation and physical model test. A 2D numerical wave flume, based on an open source computational fluid dynamics (CFD) package OpenFOAM, is applied for the numerical simulation. After numerical validations and convergent verifications, the characteristics of the fluid resonance in the gap between the twin rolling side-by-side barges are examined. The resonant frequency of the oscillating fluid in the gap between the twin rolling barges decreases compared with that between the twin fixed barges. Generally, the twin barges roll in the opposite directions, and their equilibrium positions lean oppositely with respect to the initial vertical direction. A physical model test is carried out for a further investigation, in which the twin barges are set oppositely leaning and fixed. From the present experimental results, a linear decrease of the resonant frequency with the increasing leaning angle is found. Combined with the numerical results, the deflection of the equilibrium positions of the twin barges is a relevant factor for the resonant frequency. Besides, the effects of the gap width and incident wave height on the fluid resonance coupled with roll motion are examined.
Multimorbidity prevalence and patterns and their associations with health literacy among chronic kidney disease patients
Authors: Gurgel do Amaral M. S. , Reijneveld S. A. , Meems L. M. G. , Almansa J. , Navis G. J. , de Winter A. F.
Published: January 2022

Background

Health literacy is the ability to deal with information related to one’s health. Patients with low health literacy have poor disease-management skills for chronic diseases, such as chronic kidney disease (CKD). This could influence the number and combination of their diseases.

Methods

We included adult patients with CKD stages 1–5 from the Lifelines Study (n = 2,742). We assessed the association between low health literacy and the number and patterns of comorbidities, considering them globally and stratified by age and sex, using multinomial logistic regression and latent class analysis, respectively.

Results

Low health literacy was associated with a higher number of comorbidities in the crude models, and after adjustment for age, sex, eGFR, smoking, and BMI. In the crude model, the OR for low health literacy increased from 1.71 (1.25–2.33) for two comorbidities to 2.71 (2.00–3.68) for four comorbidities. In the fully-adjusted model, the associations remained significant with a maximum OR of 1.70 (1.16–2.49) for four comorbidities. The patterns of multimorbidity were similar for low and adequate health literacy, overall and by sex, bur tended to be different for patients older than 65. Older patients with low health literacy had higher comorbidity prevalence and a relatively greater share of cardiovascular, psychiatric, and central nervous system diseases.

Conclusions

Among CKD patients, low health literacy is associated with more multimorbidity. Health literacy is not associated with patterns of multimorbidity in younger patients, but a difference was observed in older ones. Improving low health literacy could be an intervention efficient also in decreasing multimorbidity in CKD patients.

Graphical abstract
TVS: a trusted verification scheme for office documents based on blockchain
Authors: Zhai Xue , Pang Shanchen , Wang Min , Qiao Sibo , Lv Zhihan
Published: January 2022

To realize the encryption of document information, authority authentication, and traceability of historical records, we propose a trusted verification scheme (TVS) for office documents to ensure security. Specifically, the scheme is realized by timestamps, smart contracts (or chaincode), and other blockchain technologies. It is based on the features of blockchain, such as security, credibility, immutability, and traceability of network behavior. And the TVS stores users and documents information through blockchain; it can monitor the state changes of office documents in real time by setting the trigger conditions of smart contracts. The experiment indicates that we have realized the real-time monitoring of data and the traceability of historical records. Moreover, we have achieved the purpose of document encryption and authority authentication, ensuring the authenticity and objectivity of data, avoiding the illegal tampering of malicious users to realize the trusted verification for documents.
Dimensioning of a permanent magnet synchronous machine for electric vehicles according to performance and integration requirements
Authors: Künzler Moritz , Pflüger Robin , Lehmann Robert , Werner Quentin
Published: January 2022

Finding the optimum design of electrical machines for a certain purpose is a time-consuming task. First results can be achieved, however, with scaling known machine designs in length and turns per coil by means of analytical equations, while scaling in diameter requires finite element analysis (FEA), since electromagnetic properties change significantly. In this paper, the influence of diameter, length and turns per coil on the torque, power and efficiency of a permanent magnet synchronous machine (PMSM) are investigated in a sensitivity analysis. Furthermore, their impact on energy consumption in different drive cycles and different vehicle types is outlined. A highway car and a city car are compared in a highway cycle, a city cycle and the Worldwide Harmonized Light Vehicle test Cycle. The results describe significant differences in energy consumption for different machine designs in one application but also between different applications. This highlights the necessity to decide whether or not the powertrain should be optimized for a single purpose or for universal use.
Microbiological quality analysis of inoculants based on Bradyrhizobium spp. and Azospirillum brasilense produced “on farm” reveals high contamination with non-target microorganisms
Authors: Bocatti Camila Rafaeli , Ferreira Eduara , Ribeiro Renan Augusto , de Oliveira Chueire Ligia Maria , Delamuta Jakeline Renata Marçon , Kobayashi Renata Katsuko Takayama , Hungria Mariangela , Nogueira Marco Antonio
Published: January 2022

The use of inoculants carrying diazotrophic and other plant growth–promoting bacteria plays an essential role in the Brazilian agriculture, with a growing use of microorganism-based bioproducts. However, in the last few years, some farmers have multiplied microorganisms in the farm, known as “on farm” production, including inoculants of Bradyrhizobium spp. for soybean (Glycine max L. Merrill.) and Azospirillum brasilense for corn (Zea mays L.) or co-inoculation in soybean. The objective was to assess the microbiological quality of such inoculants concerning the target microorganisms and contaminants. In the laboratory, 18 samples taken in five states were serial diluted and spread on culture media for obtaining pure and morphologically distinct colonies of bacteria, totaling 85 isolates. Molecular analysis based on partial sequencing of the 16S rRNA gene revealed 25 genera of which 44% harbor species potentially pathogenic to humans; only one of the isolates was identified as Azospirillum brasilense, whereas no isolate was identified as Bradyrhizobium. Among 34 isolates belonging to genera harboring species potentially pathogenic to humans, 12 had no resistance to antibiotics, six presented intrinsic resistance, and 18 presented non-intrinsic resistance to at least one antibiotic. One of the samples analyzed with a shotgun-based metagenomics approach to check for the microbial diversity showed several genera of microorganisms, mainly Acetobacter (~ 32% of sequences) but not the target microorganism. The samples of inoculants produced on farm were highly contaminated with non-target microorganisms, some of them carrying multiple resistances to antibiotics.
A Space-Time Interior Penalty Discontinuous Galerkin Method for the Wave Equation
Authors: Shukla Poorvi , van der Vegt J. J. W.
Published: January 2022

A new higher-order accurate space-time discontinuous Galerkin (DG) method using the interior penalty flux and discontinuous basis functions, both in space and in time, is presented and fully analyzed for the second-order scalar wave equation. Special attention is given to the definition of the numerical fluxes since they are crucial for the stability and accuracy of the space-time DG method. The theoretical analysis shows that the DG discretization is stable and converges in a DG-norm on general unstructured and locally refined meshes, including local refinement in time. The space-time interior penalty DG discretization does not have a CFL-type restriction for stability. Optimal order of accuracy is obtained in the DG-norm if the mesh size h and the time step $$\Delta t$$

Δ
t

satisfy $$h\cong C\Delta t$$

h
≅
C
Δ
t

, with C a positive constant. The optimal order of accuracy of the space-time DG discretization in the DG-norm is confirmed by calculations on several model problems. These calculations also show that for pth-order tensor product basis functions the convergence rate in the $$L^\infty$$

L
∞

and $$L^2$$

L
2

-norms is order $$p+1$$

p
+
1

for polynomial orders $$p=1$$

p
=
1

and $$p=3$$

p
=
3

and order p for polynomial order $$p=2$$

p
=
2

.
Negotiating Stakeholder Relationships in a Regional Circular Economy: Discourse Analysis of Multi-scalar Policies and Company Statements from the North of England
Authors: Newsholme Aodhan , Deutz Pauline , Affolderbach Julia , Baumgartner Rupert J.
Published: January 2022

Circular economy (CE) literature discusses the need for cooperation between different stakeholders to promote a CE; there is also an assumption regarding the benefits of loop closing on a local or regional scale. However, the potentially conflicting priorities, understandings, and expectations of the stakeholders involved have not been sufficiently addressed. Regional (or local) authorities have a responsibility to promote prosperity for stakeholders in their administrative region, within the constraints of national policy; conversely companies can have financial imperatives associated with stakeholders who may be globally distributed. Evidence of these conflicting priorities, the various positions stakeholder take, and their expectations of each other can be seen in the language choices regional actors make in their public-facing policy and report documents. The aim of the paper is to consider the challenges for creating a regional-scale CE that might arise from the differing priorities and values of companies and public agencies relating to specific places. It uses discourse analysis (including critical approaches) to examine how policy and business documents represent the stakeholders of the CE, their place in it, their priorities, and, importantly, the relationship between CE actors, focusing on the case of North Humberside on the North East coast of England. The plans set out in these reports are designed for external stakeholders and allow us to gain an insight into company and policy thinking in relation to CE developments in the coming years, including how they view each other’s roles. Findings indicate a shared motivation across scales and sectors for the CE as a means towards sustainable growth within which business plays a central role. However, there is a critical double disjuncture between different visions for implementation. First, between policy scales, a regional-scale CE is prioritised by regional policymakers, who have an interest in economic advantage being tied to a specific place and call for national scale support for their actions. Second, between regional policymakers and business, companies focus on their own internal operations and potential supply chain collaborations, with little attention given to the regional scale. This can be seen in the way organisations represent the actors of a nascent CE differently. In addition, a hegemonic business-focused growth discourse excludes other visions of the CE; the public are relegated to a passive role primarily as consumers and recipients of under-specified “opportunities” of wealth creation. CE theorisations need to incorporate and address these critical perspectives in order to support the development of strategies to overcome them.
Kids With Altitude: Acute Mountain Sickness and Changes in Body Mass and Total Body Water in Children Travelling to 3800 m
Authors: Rieger Matt , Algaze Isabel , Rodriguez-Vasquez Adriana , Smith Kurt , Stembridge Mike , Smith Brianne , Radom-Aizik Shlomit , McManus Alison
Published: January 2022

Introduction

We explored the incidence of acute mountain sickness (AMS) and extravascular lung water (ELW) in children in relation to changes in body composition and peripheral blood oxygenation (SpO2) during 1 week of acclimatization to 3800 m.

Methods

In a prospective cohort study, 10 children (7 female, ages 7–14 y) and 10 sex-matched adults (ages 23–44 y) traveled via automobile from sea level to 3000 m for 2 nights, followed by 4 nights at 3800 m. Each morning, body mass and body water (bioelectrical impedance), SpO2 (pulse oximetry), AMS (Lake Louise Questionnaire), and ELW (transthoracic echocardiography) were measured.

Results

No differences were found between children and adults in SpO2 or ELW. At 3800 m 7 of 10 children were AMS+ vs 4 of 10 adults. Among those AMS+ at 3800 m, the severity was greater in children compared to adults (5±1 vs 3 ± 0; P=0.005). Loss of body mass occurred more quickly in children (day 5 vs day 7) and to a greater extent (–7±3% vs –2±2%; P<0.001); these changes were mediated via a larger relative loss in total body water in children than in adults (–6±5% vs –2±2%; P=0.027).

Conclusions

Children demonstrated a higher incidence of AMS than adults, with greater severity among those AMS+. The loss of body water and body mass at high altitude was also greater in children, albeit unrelated to AMS severity. In addition to awareness of AMS, strategies to maintain body weight and hydration in children traveling to high altitudes should be considered.
Prehospital Use of Ultrathin Reflective Foils
Authors: Kosiński Sylweriusz , Podsiadło Paweł , Darocha Tomasz , Pasquier Mathieu , Mendrala Konrad , Sanak Tomasz , Zafren Ken
Published: January 2022

Ultrathin reflective foils (URFs) are widely used to protect patients from heat loss, but there is no clear evidence that they are effective. We review the physics of thermal insulation by URFs and discuss their clinical applications. A conventional view is that the high reflectivity of the metallic side of the URF is responsible for thermal protection. In most circumstances, the heat radiated from a well-clothed body is minimal and the reflecting properties of a URF are relatively insignificant. The reflection of radiant heat can be impaired by condensation and freezing of the moisture on the inner surface and by a tight fit of the URF against the outermost layer of insulation. The protection by thermal insulating materials depends mostly on the ability to trap air and increases with the number of covering layers. A URF as a single layer may be useful in low wind conditions and moderate ambient temperature, but in cold and windy conditions a URF probably best serves as a waterproof outer covering. When a URF is used to protect against hypothermia in a wilderness emergency, it does not matter whether the gold or silver side is facing outward.
Australian Uniform Evidence Law
Authors: Hum Fiona , Urbas Gregor , Quirico Ottavio
Published: January 2022

Now in its second edition, Australian Uniform Evidence Law provides a clear, accessible introduction to the law of evidence. Following the structure of the Evidence Act 1995 (Cth), the text introduces students to basic principles, then covers more complex elements of evidence law. Cases and excerpts from legislation have been selected to guide students through the application of the Act. This edition has been updated to include significant recent case examples and decisions. Each chapter includes a summary of key points, definitions and practice questions to encourage students to apply their knowledge to realistic scenarios. The final chapter comprises longer-form, complex problems designed to test students' understanding of the concepts and rules covered in the Act as a whole. Guided solutions to each question are provided so students can check their understanding. Providing clear explanations and examples, Australian Uniform Evidence Law is an essential resource for all students of evidence law.
The Observation and Analysis of Stellar Photospheres
Authors: Gray David F.
Published: January 2022

This textbook describes the equipment, observational techniques, and analysis used in the investigation of stellar photospheres. Now in its fourth edition, the text has been thoroughly updated and revised to be more accessible to students. New figures have been added to illustrate key concepts, while diagrams have been redrawn and refreshed throughout. The book starts by developing the tools of analysis, and then demonstrates how they can be applied. Topics covered include radiation transfer, models of stellar photospheres, spectroscopic equipment, how to observe stellar spectra, and techniques for measuring stellar temperatures, radii, surface gravities, chemical composition, velocity fields, and rotation rates. Up-to-date results for real stars are included. Written for starting graduate students or advanced undergraduates, this textbook also includes a wealth of reference material useful to researchers. eBook formats include color imagery while print formats are greyscale only; a wide selection of the color images are available online.
Loneliness and Social Isolation During the COVID-19	Pandemic
Authors: Buecker Susanne , Horstmann Kai T.
Published: January 2022

Abstract. The outbreak of the global COVID-19 pandemic has drastically altered people’s lives. Loneliness and social isolation were publicly discussed as possible psychological consequences of the measures taken to slow the virus spread. These public discussions have sparked a surge in empirical studies on loneliness and social isolation. In this study, we first provide a systematic review synthesizing recent literature on the prevalence and correlates of loneliness and social isolation during the early phase of the COVID-19 pandemic ( k = 53 studies). We found that most quantitative studies included in the systematic review were cross-sectional. The few longitudinal studies mainly reported increases in loneliness, especially when the pre-pandemic measurement occasions were months or years before the COVID-19 pandemic. Studies with pre-pandemic measures weeks or days before the pandemic reported relatively stable or even decreasing loneliness trends. Second, we enrich the systematic review with an empirical investigation on daily changes in the perceived quality and quantity of social relationships during the pandemic compared to before the pandemic ( N = 4,823). This empirical investigation showed that, on average, the quality of social relationships was perceived worse during the pandemic than before. This perception got slightly stronger over the first 2 weeks of the pandemic but stagnated thereafter. Regarding the quantity of social relationships, participants reported on average that they had fewer social interactions at the beginning of the study than before the pandemic. This perceived reduction in the quantity of social interactions linearly decreased over time.
Psychological Science Into Practice During the COVID-19	Pandemic
Authors: Karayianni Eleni , Van Daele Tom , Despot-Lučanin Jasminka , Lopižić Josip , Carr Nicholas
Published: January 2022

Abstract. The public health outbreak of the COVID-19 virus has hit all aspects of life as we know it. We found ourselves trying to solve several concurrent crises that have afflicted us. The European Federation of Psychologists’ Associations (EFPA) launched the Psychologists’ Support Hub to share resources among its members and beyond and promote the continuing adoption of psychological science to battle the pandemic. In the greater context of evidence-based practice (EBP), the best available evidence is what we turn to for help in our decision-making on how best to address different challenges. However, there are challenges in implementing EBP when the science is limited, and we are still expected to be effective and efficient as professionals. The article outlines the need for EBP during the pandemic. Three vignettes display how that can be done while identifying obstacles and recommending ways forward in the future. The first one relates to the development of e-mental health services in Belgium following the March 2020 lockdown. The second describes addressing the needs of older adults in Croatia when it was hit by two crises simultaneously – the March 2020 lockdown and a destructive earthquake. The third looks at how targeted community-based interventions in Norway directed at social change can positively impact times of crisis. Overall, the pandemic presents a unique opportunity for professional growth for researchers, trainers, practitioners, and policymakers alike. EFPA can play a pivotal role in EBP adoption.
Well-Being and the COVID-19 Pandemic
Authors: Esposito Ciro , Di Napoli Immacolata , Agueli Barbara , Marino Leda , Procentese Fortuna , Arcidiacono Caterina
Published: January 2022

Abstract. The purpose of this systematic review is to analyze the COVID-19 pandemic’s effects through the lens of community psychology. Our study applied PRISMA methodology, and it was carried out using the PsycInfo, PubMed, Embase, and EBSCO databases utilizing the keywords “connectedness,” “resilience,” “shared action,” “social action,” “trust,” “individual well-being,” and “social well-being.” We selected 12 of 216 eligible publications based on the inclusion criteria. The results indicated that the role of trust in institutions and others is a protective factor for communities that experience crises, such as the COVID-19 pandemic. Moreover, developing social actions promoted connections and social support and that, in the absence of in-person communication, online communication promoted connections and reduced psychological distress and isolation. Finally, the study revealed that some psychosocial factors stem from declines in people’s well-being due to the pandemic and subsequent lockdowns. Furthermore, our findings highlighted the role of technology as a positive communication tool for promoting connectedness and social support, as well as the social function of trust in institutions. Our results suggested that community interactions at the local and virtual levels should be viewed as positive actions to support institutions in detecting the most effective social intervention measures to stimulate individual and community well-being during the pandemic. These findings may serve as a guide for health policymakers in their efforts to face the effects of the COVID-19 pandemic supporting beneficial strategies for social planning and effective public policies. Finally, both the strengths and limitations of the research will be discussed in depth.
Heterogeneous Spatial Effects of FDI on CO2 Emissions in China
Authors: Lin Hang , Wang Xingyu , Bao Ge , Xiao Huijuan
Published: January 2022

As the world’s largest CO2 emitter, China’s emission reduction is the key to mitigating global climate change. Global investment capital, as a significant influencing factor of emissions, greatly contributes to China’s economic growth and stimulates frequent interprovincial trade since the reform and opening. However, the spatial correlation of foreign investment and CO2 emissions across Chinese provinces is rarely considered. This paper explores the role of foreign direct investment (FDI) in emission reduction in China during 2004–2015 using the spatial Durbin economic models with two‐way fixed effects. Then, the partial differential equations decomposition of the local and spatial spillover effects is conducted for capturing the marginal effects of influencing factors. Results show that FDI contributes to emission reduction for the whole country, whereas interprovincial transmission and intra‐provincial transmission show significant heterogeneity. Specifically, FDI increases emissions in host areas, while FDI provides positive environmental externalities to adjacent areas through spatial spillovers. Our findings provide a new perspective to explain the coexistence of the “Pollution Haven” and “Pollution Halo” theories in a country. Also, the exploration of spatial spillover effects of FDI on emissions can provide a reference for other countries with rising trade and investment flows to promote collaborative emission reduction.
Formation of Rolling‐Pin Distribution of Suprathermal Electrons Behind Dipolarization Fronts
Authors: Fu W. D. , Fu H. S. , Cao J. B. , Yu Y. , Chen Z. Z. , Xu Y.
Published: January 2022

The rolling‐pin distribution of suprathermal electrons, exhibiting electron pitch angles primarily at 0°, 90°, and 180°, receives attention in both observations and simulations recently. However, its formation mechanism has rarely been studied. In this work, we report an observation of such distribution with two substructures behind the dipolarization front (DF) and reveal that only Fermi mechanism is contributory to suprathermal electron acceleration. We present a new explanation for its formation. The Fermi mechanism accelerates parallel and antiparallel suprathermal electrons, the spatially varying magnetic bottles control the emergence of perpendicular electrons, and electrons whose pitch angle around 45° and 135° drift away in the middle magnetotail. Under the combination of these mechanisms, the rolling‐pin distribution with two substructures is formed behind DFs. This formation mechanism is useful to understand the electron dynamics behind DFs.
Relation of Jupiter's Dawnside Main Emission Intensity to Magnetospheric Currents During the Juno Mission
Authors: Nichols J. D. , Cowley S. W. H.
Published: January 2022

We compare Jupiter's dawn‐side main auroral emission intensity observed by the Hubble Space Telescope with the simultaneous magnitude of the dawn‐side magnetospheric equatorial radial current as observed by Juno during Orbits 3–7. We show that the peak auroral intensity and the square of the radial current per radian of azimuth are strongly correlated with R ≈ 0.9, and that the chance that the two phenomena are unrelated is negligible. We also fit empirical profiles of the total radial current flowing per radian of azimuth to the observed values and estimate the precipitating electron energy flux during each observation, and show this exhibits a similar correlation to the current. We find 1 mW m−2 of precipitating energy flux is associated with ∼5–11 kR of auroral emission, consistent with modeling studies. This is the first demonstration of a statistical relationship between the intensity of Jupiter's auroras and the strength of the magnetospheric currents, specifically the radial current, the j × B force of which accelerates plasma in the sense of planetary rotation. This result provides compelling evidence that the magnetosphere‐ionosphere coupling current system at Jupiter plays a key role in powering the planet's dawn side main auroral emission. We further show that there is no association between the auroral intensity and the rate of change of the magnetic energy density outside the current sheet.
Formation of Metamorphic Soles Underlying Ophiolites During Subduction Initiation: A Systematic Numerical Study
Authors: Zhong Xinyi , Li Zhong‐Hai
Published: January 2022

The understanding of subduction initiation (SI) remains ambiguous due to limited geological records. The metamorphic sole, generally considered to be generated by oceanic crustal metamorphism during SI, is characterized by high temperature condition (∼800°C) at shallow depths (<40 km). However, the exact tectonic setting of the metamorphic sole with such a high geothermal gradient is still controversial. The petrological and geochemical signatures of ophiolites and metamorphic soles in nature indicate three different types: (a) supra‐subduction zone (SSZ)‐type ophiolite with mid‐ocean ridge basalt (MORB)‐type metamorphic sole; (b) SSZ‐type ophiolite with SSZ‐type metamorphic sole; and (c) MORB‐type ophiolite with MORB‐type metamorphic sole. To clarify the conditions of metamorphic sole generation in different tectonic settings, a series of numerical models are conducted. The model results indicate that the SI at a (back‐arc) spreading center or spontaneous SI at a transform fault provides the favorable high‐temperature condition for formation of the metamorphic sole underlying the ophiolite. The former regime generates SSZ‐type ophiolite with SSZ‐type sole, whereas the latter generates SSZ‐type ophiolite with MORB‐type sole. The P‐T conditions of natural metamorphic soles may not represent the characteristic subduction channel condition for the majority of ophiolites, but stand for the end‐member high‐temperature regime that facilitates weakening, detachment and further exhumation of metamorphic soles. It thus illustrates the less widely distributed metamorphic soles than ophiolites in nature. The model results are further compared with three present‐day back‐arc basins on the Earth to evaluate the likelihood of future metamorphic sole generation and preservation in these basins.
Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice
Authors: Wang Zuqiang , Chen Hangang , Tan Qiaoyan , Huang Junlan , Zhou Siru , Luo Fengtao , Zhang Dali , Yang Jing , Li Can , Chen Bo , Sun Xianding , Kuang Liang , Jiang Wanling , Ni Zhenhong , Wang Quan , Chen Shuai , Du Xiaolan , Chen Di , Deng Chuxia , Yin Liangjun , Chen Lin , Xie Yangli
Published: January 2022

The intervertebral disc (IVD) is the largest avascular tissue. Hypoxia-inducible factors (HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease (DDD) is one of the leading causes of disability, and current therapies are ineffective. This study sought to explore the role of HIFs in DDD pathogenesis in mice. The findings of this study showed that among HIF family members, Hif1α was significantly upregulated in cartilaginous endplate (EP) and annulus fibrosus (AF) tissues from human DDD patients and two mouse models of DDD compared with controls. Conditional deletion of the E3 ubiquitin ligaseVhlin EP and AF tissues of adult mice resulted in upregulated Hif1α expression and age-dependent IVD degeneration. Aberrant Hif1α activation enhanced glycolytic metabolism and suppressed mitochondrial function. On the other hand, genetic ablation of theHif1αgene delayed DDD pathogenesis inVhl-deficient mice. Administration of 2-methoxyestradiol (2ME2), a selective Hif1α inhibitor, attenuated experimental IVD degeneration in mice. The findings of this study show that aberrant Hif1α activation in EP and AF tissues induces pathological changes in DDD, implying that inhibition of aberrant Hif1α activity is a potential therapeutic strategy for DDD.
No evidence for increased cell entry or antibody evasion by Delta sublineage AY.4.2
Authors: Arora Prerna , Kempf Amy , Nehlmeier Inga , Graichen Luise , Winkler Martin S. , Lier Martin , Schulz Sebastian , Jäck Hans-Martin , Pöhlmann Stefan , Hoffmann Markus
Published: January 2022

Since the beginning of the COVID-19 pandemic, multiple SARS-CoV-2 variants have emerged. While some variants spread only locally, others, referred to as variants of concern, disseminated globally and became drivers of the pandemic. All SARS-CoV-2 variants harbor mutations relative to the virus circulating early in the pandemic, and mutations in the viral spike (S) protein are considered of particular relevance since the S protein mediates host cell entry and constitutes the key target of the neutralizing antibody response. As a consequence, mutations in the S protein may increase SARS-CoV-2 infectivity and enable its evasion of neutralizing antibodies. Furthermore, mutations in the S protein can modulate viral transmissibility and pathogenicity.
Retinoblastoma and vision
Authors: Warda Omar , Naeem Zishan , Roelofs Kelsey A. , Sagoo Mandeep S. , Reddy M. Ashwin
Published: January 2022

The assessment of vision has a growing importance in the management of retinoblastoma in the era of globe-conserving therapy, both prior to and after treatment. As survival rates approach 98–99% and globe salvage rates reach ever-higher levels, it is important to provide families with information regarding the visual outcomes of different treatments. We present an overview of the role of vision in determining the treatment given and the impact of complications of treatment. We also discuss screening and treatment strategies that can be used to maximise vision.