bluuebunny/crossref_metadata_2025 huggingface dataset:
Riemann Zeta Function and Dirichlet Eta Function relating to Alternative Harmonic Series
Authors: Annamalai Chinnaraji
Published: August 2024

This paper discusses how the Dirichlet eta function relates to the alternative harmonic series and the Riemann zeta function in more detail. In this article, theorems with proof on the alternative harmonic series and relation between the Dirichlet eta function and the Riemann zeta function are provided to improve the research techniques further in the area of analytic number theory.
Cambridge Permanence and Durability Voluntary Carbon Market Workshop: Resources and Summary
Authors: Hunnable Harriet , Mayer Braeden , Kelly Alexia , Strong Julia , Barata Pedro
Published: August 2024

Over sixty experts from across the voluntary carbon market ecosystem — policymakers, practitioners, academia convened at the University of Cambridge on January 31 & February 1, 2024 to discuss issues and challenges related to permanence and durability and identify potential solutions for the continued development of the market. Historically there has been a lack of consistent accounting for differences in storage duration and risk in the voluntary carbon market. It was agreed that the materials from the workshop would be used as an input to the Integrity Council for the Voluntary Carbon Market’s Continuous Improvement Work Program (IC-VCM CIWP) on Permanence due to commence spring 2024. After publishing its Core Carbon Principles and corresponding Assessment Framework in July 2023, the IC-VCM launched the CIWPs to consider key issues related to the future of the carbon markets and to develop recommendations to inform the next iteration of IC-VCM Core Carbon Principles label requirements. Materials include the pre workshop resources sent to all participants and the post event summary, aggregated, anonymized, synthesised participant views on key topics and the workshop systems design exercise outputs. These are made available on Cambridge Open Engage as a research summary/ policy brief by Harriet Hunnable at the Cambridge Centre for Carbon Credits (4C) on behalf of the workshop conveners and facilitators: Pedro Barata, Harriet Hunnable, Alexia Kelly, Braeden Mayer and Julia Strong.
Digital Transformation in Management Accounting: Towards Efficiency and Competitive Advantage
Authors: Rosmala Cici
Published: August 2024

Exploring the impact of digital transformation on management accounting, this study aims to identify pathways towards enhanced efficiency and competitive advantage. Employing a qualitative research design, the investigation involved a purposive sampling of medium-sized enterprises, with data gathered through structured interviews and analyzed using thematic analysis. The findings reveal significant shifts in operational dynamics, notably in data management and strategic decision-making, with themes highlighting the integration of advanced technologies fostering streamlined processes. Discussion centers on the implications of these transformations for organizational agility and market positioning. The study concludes with recommendations for leveraging digital tools to reinforce management accounting practices, ultimately contributing to sustained organizational growth
Rhizobium etli CFN42 and Sinorhizobium meliloti 1021 bioinformatic transcriptional regulatory networks from culture and symbiosis
Authors: Taboada-Castro Hermenegildo , Hernández-Álvarez Alfredo José , Escorcia-Rodríguez Juan Miguel , Freyre-González Julio Augusto , Galán-Vásquez Edgardo , Encarnación-Guevara Sergio
Published: August 2024

Rhizobium etli CFN42 proteome–transcriptome mixed data of exponential growth and nitrogen-fixing bacteroids, as well as Sinorhizobium meliloti 1021 transcriptome data of growth and nitrogen-fixing bacteroids, were integrated into transcriptional regulatory networks (TRNs). The one-step construction network consisted of a matrix-clustering analysis of matrices of the gene profile and all matrices of the transcription factors (TFs) of their genome. The networks were constructed with the prediction of regulatory network application of the RhizoBindingSites database (http://rhizobindingsites.ccg.unam.mx/). The deduced free-living Rhizobium etli network contained 1,146 genes, including 380 TFs and 12 sigma factors. In addition, the bacteroid R. etli CFN42 network contained 884 genes, where 364 were TFs, and 12 were sigma factors, whereas the deduced free-living Sinorhizobium meliloti 1021 network contained 643 genes, where 259 were TFs and seven were sigma factors, and the bacteroid Sinorhizobium meliloti 1021 network contained 357 genes, where 210 were TFs and six were sigma factors. The similarity of these deduced condition-dependent networks and the biological E. coli and B. subtilis independent condition networks segregates from the random Erdös–Rényi networks. Deduced networks showed a low average clustering coefficient. They were not scale-free, showing a gradually diminishing hierarchy of TFs in contrast to the hierarchy role of the sigma factor rpoD in the E. coli K12 network. For rhizobia networks, partitioning the genome in the chromosome, chromids, and plasmids, where essential genes are distributed, and the symbiotic ability that is mostly coded in plasmids, may alter the structure of these deduced condition-dependent networks. It provides potential TF gen–target relationship data for constructing regulons, which are the basic units of a TRN.
Determination of glucose cut-off points for optimal performance of glucagon stimulation test
Authors: Kawalec Joanna , Horzelski Wojciech , Karbownik-Lewińska Małgorzata , Lewiński Andrzej , Lewandowski Krzysztof C.
Published: August 2024

Introduction

The glucagon stimulation test (GST) is widely used to assess growth hormone (GH) and cortisol secretion, nevertheless the precise mechanisms underpinning these hormonal responses remain unclear. We have endeavoured to explore the relationship between glucose and insulin fluctuations during GST and their impact on GH and cortisol secretion.

Subjects and methods

We retrospectively studied 139 subjects (mean age 35.5 ± 15.1 years, BMI 26.6 ± 6.61 kg/m²), including 62 individuals with a history of pituitary disease (27 with an intact adrenal axis) and 77 healthy controls. Standard dose intramuscular GST was performed in all subjects.

Results

Once BMI and age were excluded from multivariate model, the nadir of glucose concentration during GST was the sole variable associated with maximal GH secretion (ΔGH, p<0.0003), while neither glucose/insulin peak, nor Δglucose/Δinsulin concentrations contributed to ΔGH. 100% pass rate for GH secretion above 3 ng/ml or 1.07 ng/ml cut-offs was observed for glucose concentrations at, or below 60 mg/dl (3.33 mmol/l) (for Controls), or 62 mg/dl (3.44 mmol/l) (for Controls and patients with an intact adrenocortical axis). Such low glucose concentrations were obtained, however, only in about 30% of studied individuals. Conversely, cortisol secretion did not correlate with glucose or insulin fluctuations, suggesting alternative regulatory mechanisms.

Conclusions

This study reveals that glucose nadir below 3.33 mmol/l is the only biochemical biovariable linked with optimal GH secretion during GST, whereas mechanisms responsible for cortisol secretion remain unclear. We emphasize the importance of glucose monitoring during GST to validate GH stimulation and support clinical decisions in GH deficiency management.
Climate neutrality of the French energy system: overview and impacts of sustainable aviation fuel production
Authors: Merceron Louis , Boissonnet Guillaume , Maréchal François
Published: August 2024

CO2 emission reduction of sectors such as aviation, maritime shipping, road haulage, and chemical production is challenging but necessary. Although these sectors will most likely continue to rely on carbonaceous energy carriers, they are expected to gradually shift away from fossil fuels. In order to do so, the prominent option is to utilize alternative carbon sources—like biomass and CO2 originating from carbon capture—for the production of non-fossil carbonaceous vectors (biofuels and e-fuels). However, the limited availability of biomass and the varying nature of other carbon sources necessitate a comprehensive evaluation of trade-offs between potential carbon uses and existing sources. Then, it is primordial to understand the origin of carbon used in sustainable aviation fuel (SAF) to understand the implications of defossilizing aviation for the energy system. Moreover, the production of SAF implies deep changes to the energy system that are quantified in this work. This study utilizes the linear programming cost optimization tool EnergyScope TD to analyze the holistic French energy system, encompassing transport, industry, electricity, and heat sectors while ensuring net greenhouse gas neutrality. A novel method to model and quantify carbon flows within the system is introduced, enabling a comprehensive assessment of greenhouse gas neutrality. This study highlights the significance of fulfilling clean energy requirements and implementing carbon dioxide removal measures as crucial steps toward achieving climate neutrality. Indeed, to reach climate neutrality, a production of 1,046 TWh of electricity by non-fossil sources is needed. Furthermore, the findings underscore the critical role of efficient carbon and energy valorization from biomass, providing evidence that producing fuels by combining biomass and hydrogen is optimal. The study also offers valuable insights into the future cost and impact of SAF production for air travel originating from France. That is, the European law ReFuelEU would increase the price of plane tickets by +33% and would require 126 TWh of hydrogen and 50 TWh of biomass to produce the necessary 91 TWh of jet fuel. Finally, the implications of the assumption behind the production of SAF are discussed.
Growth conditions of tree species relative to climate change and sea level rise in low-lying Mid Atlantic coastal forests
Authors: Haaf LeeAnn , Dymond Salli F.
Published: August 2024

Introduction

Coastal forests occupy low-lying elevations, typically adjacent to tidal salt marshes. Exposed to increased flooding with sea level rise, coastal forests have retreated as salt marshes advance upslope. Coastal forests likely currently experience periodic tidal flooding, but whether they temporarily accommodate or quickly succumb to rising sea level under changing climatic conditions remains a complex question. Disentangling how tidal flooding and climate affect tree growth is important for gauging which coastal forests are most at risk of loss with increasing sea levels.

Methods

Here, dendrochronology was used to study tree growth relative to climate variables and tidal flooding. Specifically, gradients in environmental conditions were compared to species-specific (Pinus taeda, Pinus rigida, Ilex opaca) growth in coastal forests of two estuaries (Delaware and Barnegat Bays). Gradient boosted linear regression, a machine learning approach, was used to investigate tree growth responses across gradients in temperature, precipitation, and tidal water levels. Whether tree ring widths increased or decreased with changes in each parameter was compared to predictions for seasonal climate and mean high water level to identify potential vulnerabilities.

Results

These comparisons suggested that climate change as well as increased flood frequency will have mixed, and often non-linear, effects on coastal forests. Variation in responses was observed across sites and within species, supporting that site-specific conditions have a strong influence on coastal forest response to environmental change.

Discussion

Site- and species-specific factors will be important considerations for managing coastal forests given increasing tidal flood frequencies and climatic changes.
Can infrared light really be doing what we claim it is doing? Infrared light penetration principles, practices, and limitations
Authors: Henderson Theodore A.
Published: August 2024

Near infrared (NIR) light has been shown to provide beneficial treatment of traumatic brain injury (TBI) and other neurological problems. This concept has spawned a plethora of commercial entities and practitioners utilizing panels of light emitting diodes (LEDs) and promising to treat patients with TBI and other disorders, who are desperate for some treatment for their untreatable conditions. Unfortunately, an LED intended to deliver photonic energy to the human brain does not necessarily do what an LED pointed at a mouse brain does. There is a problem of scale. Extensive prior research has shown that infrared light from a 0.5-watt LED will not penetrate the scalp and skull of a human. Both the properties of NIR light and the manner in which it interacts with tissue are examined. Based on these principles, the shortcomings of current approaches to treating neurological disorders with NIR light are explored. Claims of clinical benefit from low-level LED-based devices are explored and the proof of concept challenged. To date, that proof is thin with marginal benefits which are largely transient. Extensive research has shown fluence at the level of the target tissue which falls within the range of 0.9 J/cm2 to 15 J/cm2 is most effective in activating the biological processes at the cellular level which underlie direct photobiomodulation. If low-level infrared light from LED devices is not penetrating the scalp and skull, then these devices certainly are not delivering that level of fluence to the neurons of the subjacent brain. Alternative mechanisms, such as remote photobiomodulation, which may underlie the small and transient benefits for TBI symptoms reported for low-power LED-based NIR studies are presented. Actionable recommendations for the field are offered.
Adaptation of Almond Cultivars in Majorca Island: Agronomical, Productive, and Fruit Quality Characteristics
Authors: Llompart Miquel , Barceló Miguel , Pou Jeroni , Luna Joana Maria , Miarnau Xavier , Garau Maria Carme
Published: August 2024

Almond cultivation has a long-standing tradition on the island of Majorca, traditionally practiced under rainfed conditions. Currently, new plantations are established with irrigation; however, due to present conditions and the impacts of climate change, water availability is limited. The Government of the Balearic Islands permits a maximum water supply of 3000 m3 ha−1 per year for almond cultivation. In this study, a 6-year field trial was conducted to investigate the adaptation of fourteen almond cultivars obtained from different research centers under deficit irrigation practices in the soil and climatic conditions of Majorca Island. The cultivars had a significant effect on trunk cross-sectional area TCSA, cumulative almond in-shell yield, cumulative kernel yield, yield efficiency, and shelling percentage. The ‘Marta’ and ‘Tarraco’ cultivars exhibited the highest TCSA values. Regarding cumulative almond in-shell yield, ‘Glorieta’ and ‘Constantí’ produced the highest yields, whereas the lowest yields were observed in ‘Mardía’ and ‘Tarraco’. In terms of shelling percentage, ‘Ferragnès’ exhibited the highest value. Kernel quality parameters were cultivar-specific. Additionally, oleic acid content was strongly negatively correlated with linoleic acid content. All cultivars exhibited an unsaturated fatty acid content exceeding 90%, with ‘Masbovera’ showing the highest value.
Research on Lightweight Rice False Smut Disease Identification Method Based on Improved YOLOv8n Model
Authors: Yang Lulu , Guo Fuxu , Zhang Hongze , Cao Yingli , Feng Shuai
Published: August 2024

In order to detect rice false smut quickly and accurately, a lightweight false smut detection model, YOLOv8n-MBS, was proposed in this study. The model introduces the C2f_MSEC module to replace C2f in the backbone network for better extraction of key features of false smut, enhances the feature fusion capability of the neck network for different sizes of false smut by using a weighted bidirectional feature pyramid network, and designs a group-normalized shared convolution lightweight detection head to reduce the number of parameters in the model head to achieve model lightweight. The experimental results show that YOLOv8n-MBS has an average accuracy of 93.9%, a parameter count of 1.4 M, and a model size of 3.3 MB. Compared with the SSD model, the average accuracy of the model in this study increased by 4%, the number of parameters decreased by 89.8%, and the model size decreased by 86.9%; compared with the YOLO series of YOLOv7-tiny, YOLOv5n, YOLOv5s, and YOLOv8n models, the YOLOv8n-MBS model showed outstanding performance in terms of model accuracy and model performance detection; compared to the latest YOLOv9t and YOLOv10n models, the average model accuracy increased by 2.8% and 2.2%, the number of model parameters decreased by 30% and 39.1%, and the model size decreased by 29.8% and 43.1%, respectively. This method enables more accurate and lighter-weight detection of false smut, which provides the basis for intelligent management of rice blast disease in the field and thus promotes food security.
Design and Experiments of a Roll-Knife Pickup for a Buckwheat Pickup Harvester
Authors: Ye Shaobo , Wang Xiaolei , Zhang Chao , Zhang Jianlong , Wang Jiawei , Zheng Decong
Published: August 2024

To reduce grain loss during pickup and prevent stalk entanglement in buckwheat harvesters, thereby improving the quality of mechanized harvesting, a three-stage pickup conveyor roll with a ground-level rotary knife-type pickup header was designed and tested. This paper, based on the growth characteristics of buckwheat, determined the three-stage pickup conveying process and the overall structure of the ground-level rotary knife-type pickup header. Kinematic analysis and parameter design of the rotary knife-type pickup roll were conducted. Finally, a physical prototype was fabricated, and field performance tests were carried out, using machine forward speed and pickup roll rotational speed as influencing factors and pickup loss rate as an evaluation metric. Results showed that the interaction between pickup roll rotational speed and forward speed had a significant effect on the pickup loss rate, with forward speed having a greater impact than pickup roll rotational speed. Under consideration of their interaction, when the pickup roll rotational speed was within the range of 396–457 r/min, and the forward speed was between 0.9–1.0 m/s, the pickup loss rate was minimized. Based on the regression equation model, the predicted optimal conditions were a forward speed of 1.0 m/s and a roll pickup speed of 396 rpm. Under these conditions, the test results showed a pickup loss rate of 5.235%, indicating good pickup performance. This research provides a reference for the design of pickup devices in grain combine harvesters.
The Effect of the Species Source of Muscle and/or Digestive Enzymes on the Utilization of Fish Protein Hydrolysates as a Dietary Protein Source in First Feed for Larval Walleye (Sander vitreus)
Authors: Molinari Giovanni S. , Wojno Michal , Terova Genciana , Wick Macdonald , Riley Hayden , Caminiti Jeffery T. , Kwasek Karolina
Published: August 2024

Fish protein hydrolysates used in larval diets have been prepared from a variety of fish species, with different enzymes used to hydrolyze the protein. This study’s objectives were to determine the effect of the dietary inclusion of fish muscle hydrolysates obtained from species-specific muscle/enzymes—versus hydrolysates produced from muscle/enzymes of a different species—on the growth performance, survival, skeletal development, intestinal peptide uptake, and muscle-free amino acid (FAA) composition of larval Walleye (Sander vitreus). Eight protein products were obtained for this study, comprising an unhydrolyzed and hydrolyzed product from each combination of muscle/enzymes from Walleye and Nile tilapia (Oreochromis niloticus). Four diets were produced, and the dietary protein was provided in a 50/50 ratio of unhydrolyzed and hydrolyzed protein from the respective muscle/enzyme combination. Four groups were fed one of the corresponding formulated diets, and two groups of larvae, fed a commercial starter diet and Artemia, respectively, served as reference groups. Larval Walleye fed the diet containing protein produced with the species-specific muscle and enzymes had a significantly higher weight after the study—30% higher than any other group. A significant interaction effect between muscle and enzyme sources on the growth of Walleye larvae was observed. The species-specific combination also led to a significant increase in postprandial FAA and indispensable amino acid concentrations in muscle. No significant differences were observed between the hydrolysate-fed groups in survival, deformity occurrence, or peptide uptake. Each hydrolysate-based diet significantly reduced skeletal deformities and survival compared to the commercial diet. The results of this study suggest that species-specific muscles and enzymes produce a more optimal dietary protein source for larval fish than non-species-specific products. Further research should focus on improving the physical properties of the formulated diets to reduce possible leaching of hydrolyzed protein and improve the survival of fish larvae.
Assessing the Impact of On-Farm Biosecurity Coaching on Farmer Perception and Farm Biosecurity Status in Belgian Poultry Production
Authors: Amalraj Arthi , Van Meirhaeghe Hilde , Chantziaras Ilias , Dewulf Jeroen
Published: August 2024

Veterinary coaching was tested to assess its efficacy in promoting adherence to biosecurity procedures. Poultry farmers (n = 13) in Belgium were profiled using ADKAR®, coached and audited prior to and 6 months after coaching. The ADKAR® (Awareness, Desire, Knowledge, Ability, and Reinforcement) profiling technique identified 5/13 participating farmers with relatively low scores (≤3) for one or more elements that block change (biosecurity compliance in this case). Education was the only demographic variable that influenced knowledge scores. Through the Biocheck.UgentTM methodology, farm biosecurity was assessed and benchmarked to allow for tailored guidance. The farmer, farm veterinarian, and coach defined a farm-specific action plan that covered infrastructure, site access, staff/visitors, purchase policies, transport and depopulation, feed and water supplies, flock management, cleaning and disinfection between flocks, and measures between houses. From a total of 49 proposed actions, 36 were adopted. Purchasing policy had the highest (100%) and cleaning and disinfection had the lowest compliance (38%). Time, cost, and feasibility (e.g., inadequate farm layout) were the main reasons cited for not implementing action points. Overall, biosecurity improved significantly (p = 0.002) from 67.1 ± 5.7% to 70.3 ± 5.7% (mean ± Std. dev). The study, hence, presents convincing proof of how coaching can lead to new solutions not previously considered.
Reproductive Dynamics of Spot Tail Mantis Shrimp (Squilla mantis): Insights from the Central Mediterranean Sea
Authors: Colella Sabrina , Mascoli Alessia , Donato Fortunata , Panfili Monica , Santojanni Alberto , Gioacchini Giorgia
Published: August 2024

Fisheries management requires improvement in scientific knowledge to ensure sustainable exploitation of important commercial species and population renewal. Within this context, this study focused on the reproductive biology of spot tail mantis shrimp, Squilla mantis, in the Central Mediterranean Sea, aiming to understand the reproductive pattern of this species and validate the macroscopic maturity scale through histological analysis. A multi-year sampling was performed from 2016 to 2020 by a commercial fishing fleet in the Northern Central Adriatic Sea (GSA 17), and a total of 2206 individuals were collected. The monthly average value of the total sex ratio of S. mantis was 0.524 ± 0.044 (mean ± SEM) in favor of females, which dominated the population from September to April. The proposed 5 stage macroscopic maturity scale was validated histologically through histological analysis, confirming synchronous ovarian development. The somatic indexes (GSI and K Fulton) and monthly incidence of macroscopic ovarian maturity stages highlighted a protracted reproductive season from winter to spring (January–May). Although the length-weight relationship showed a similar growth trend between genders, males reached a bigger size in terms of carapace length (C.L.) and dominated the population from 32 mm (C.L.). The macroscopic L50 estimated was 25.94 mm (C.L.).
Health Risk Assessment of Ambient Volatile Organic Compounds in a Border City in Canada
Authors: Mihankhah Taraneh , Su Yushan , Zhang Tianchu , Wang Jonathan , Gilmore James , Noble Michael , Munoz Anthony , Charron Chris , Xu Xiaohong
Published: August 2024

This study characterizes cancer and non-cancer risks due to inhalation exposure to volatile organic compounds (VOCs) in a border city of Windsor in southern Ontario, Canada, using hourly ambient concentrations collected from 17 November 2021 to 17 March 2023. The total incremental lifetime cancer risk (CR) due to benzene and ethylbenzene is 4.33 × 10−6, which is in the acceptable risk range of 1 × 10−6 to 1 × 10−4 used by the USEPA. The CR was higher in winter (5.20 × 10−6), followed by fall (4.32 × 10−6), spring (3.86 × 10−6), and summer (2.96 × 10−6), all in the acceptable range. The total chronic non-cancer risk (Hazard Quotient, HQ) of inhalation exposure to 16 VOCs was 0.0488, with a higher value in fall (0.0571), followed by winter (0.0464), and lower in spring (0.0454) and summer (0.0451), all in the safe level of below HQ = 1 used by the USEPA. The hazard index (HI) by organs was higher for the nervous system (0.0213), followed by the hematologic system and immune system (0.0165 each), but much lower for the other five target organs, i.e., the liver/kidney (1.52 × 10−4), developmental system (3.38 × 10−4), endocrine system and urinary system (2.82 × 10−4 each), and respiratory system (9.70 × 10−5). Similar hour-of-day trends were observed in the total CR, total HQ, and HI by organs with higher values in the early morning hours of 5:00–8:00 and lower values during 12:00 to 15:00. Benzene was the major contributor to both total CR (89%) and total HQ (34%) due to its high toxicity and high concentrations. Benzene, toluene, ethylbenzene, and xylenes (BTEX) contributed 100% of the total CR and 51% of the total HQ. Further, BTEX is the sole contributor to the HI for the hematologic system and immune system and the major contributor to the HI for the nervous system (39%) and developmental system (55%). Higher cancer and non-cancer risks were associated with the airmass from the east, southeast, and southwest of Windsor.
Epilepsy and Myasthenia Gravis: A Case Series
Authors: Oyarzun Iñigo , Hernández Guillermo , Sala-Padró Jacint , Morandeira Francisco , Casasnovas Carlos , Falip Mercè
Published: August 2024

The association between epilepsy and myasthenia gravis has rarely been reported, and when it has been reported, it has only been in a small case series. The aim of the present study was to report the frequency of epilepsy and myasthenia gravis and to describe a case series of patients with myasthenia gravis and epilepsy, focusing on their clinical characteristics and searching for a possible physiopathological mechanism. A retrospective, observational, adult center study was conducted in 2022. Patients were recruited from the database of the outpatient clinic of the Myasthenia Gravis and Epilepsy Unit of the Neurology Service, Hospital Universitari de Bellvitge. Five patients were included. The frequency of epilepsy in the myasthenia gravis cohort was 5/469 (1.1%), and the frequency of myasthenia gravis in the epilepsy cohort was 5/1432 (0.35%). All patients suffered from focal epilepsy, mainly temporo-central, which was drug-resistant in 3/5 Myasthenia gravis, which was generalized and with exacerbations in 3/5. Three patients were thymectomized (anatomopathology: thymic hyperplasia). Other autoimmune diseases were found in two (40%). Epilepsy onset preceded myasthenia gravis onset in all patients. Both diseases were considered autoimmune-related in 3/5, related to genetic predisposition due to altered innate immune system in 1/5, and due to chance or to treatment in 1/5. Epilepsy and myasthenia gravis are only infrequently associated. In adult patients, epilepsy onset precedes myasthenia onset in most cases. In some cases, epilepsy has an autoimmune etiology and coexists with other autoimmune conditions.
Machine Learning Predicts Phenoconversion from Polysomnography in Isolated REM Sleep Behavior Disorder
Authors: Cesari Matteo , Portscher Andrea , Stefani Ambra , Angerbauer Raphael , Ibrahim Abubaker , Brandauer Elisabeth , Feuerstein Simon , Egger Kristin , Högl Birgit , Rodriguez-Sanchez Antonio
Published: August 2024

Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal stage of alpha-synucleinopathies. This study aimed at developing a fully-automated machine learning framework for the prediction of phenoconversion in patients with iRBD by using data recorded during polysomnography (PSG). A total of 66 patients with iRBD were included, of whom 18 converted to an overt alpha-synucleinopathy within 2.7 ± 1.0 years. For each patient, a baseline PSG was available. Sleep stages were scored automatically, and time and frequency domain features were derived from electromyography (EMG) and electroencephalography (EEG) signals in REM and non-REM sleep. Random survival forest was employed to predict the time to phenoconversion, using a four-fold cross-validation scheme and by testing several combinations of features. The best test performances were obtained when considering EEG features in REM sleep only (Harrel’s C-index: 0.723 ± 0.113; Uno’s C-index: 0.741 ± 0.11; integrated Brier score: 0.174 ± 0.06). Features describing EEG slowing had high importance for the machine learning model. This is the first study employing machine learning applied to PSG to predict phenoconversion in patients with iRBD. If confirmed in larger cohorts, these findings might contribute to improving the design of clinical trials for neuroprotective treatments.
Differentiated Empowering Leadership and Interpersonal Counterproductive Work Behaviors: A Chained Mediation Model
Authors: Song Yuanzhao , Zhou Haining , Choi Myeong-Cheol
Published: August 2024

Through an empirical analysis of paired sample data from 308 employees in China, this study examines the chain-mediated effects of trust in leaders and defensive silence on the relationship between differentiated empowering leadership and interpersonal counterproductive work behaviors. The study finds that differentiated empowering leadership does not directly influence employees’ interpersonal counterproductive work behaviors. Additionally, it finds that trust in leaders and defensive silence each serve as mediators in the relationship between differentiated empowering leadership and interpersonal counterproductive work behaviors, forming a chained mediation effect. This study is the first empirical research to explore the impact mechanism of differentiated empowering leadership using a chained mediation model. The findings contribute to a deeper understanding of how and why differentiated empowering leadership affects employees’ attitudes, such as trust in leaders, and behaviors, such as interpersonal counterproductive work behaviors.
A Post Occupancy Evaluation of the Space Utilization of Cultural Heritage in Children’s Education: A Case Study of Wuhan’s Historical Districts, China
Authors: Xiao Wei , Yoon Jae-Eun
Published: August 2024

Cultural heritage has educational value because it provides children with a realistic learning environment and a wealth of educational resources. This study intends to fill a gap in academic research by evaluating the efficiency of utilizing cultural heritage in children’s education. This study uses the Post Occupancy Evaluation (POE) method to create a comprehensive evaluation index system. Through research and analysis of six key elements—inheritance of historical context, improvement in environmental quality, completion of infrastructure, achievement of educational goals, participation in children in activities, and sustainable development—it was discovered that rational utilization of cultural heritage space significantly improves the educational experience and promotes cultural heritage transmission. This study is significant since it provides an empirical foundation for educational practice and serves as a valuable guide for innovative heritage transmission and policy creation. Our findings emphasize the necessity of incorporating educational goals into preserving and revitalizing cultural heritage, advocating for a forward-thinking approach that honors the past while fostering learning and progress for future generations.
Study on the Effect of Silica–Manganese Slag Mixing on the Deterioration Resistance of Concrete under the Action of Salt Freezing
Authors: He Jingjing , Sun Chuanwu , Hu Wei , Ni Zhipeng , Yin Xiangwen , Wang Xuezhi
Published: August 2024

The use of silico-manganese slag as a substitute for cement in the preparation of concrete will not only reduce pollution in the atmosphere and on land due to solid waste but also reduce the cost of concrete. To explore this possibility, silico-manganese slag concrete was prepared by using silico-manganese slag as an auxiliary cementitious material instead of ordinary silicate cement. The mechanical properties of the silico-manganese slag concrete were investigated by means of slump and cubic compressive strength tests. The rates of mass loss and strength loss of silico-manganese slag concrete were tested after 25, 50, and 75 cycles. The effect of the silica–manganese slag admixture on the microfine structure and properties of concrete was also investigated using scanning electron microscopy (SEM). Finally, the damage to the silica–manganese slag concrete after numerous salt freezing cycles was predicted using the Weibull model. The maximum enhancement of slump and compressive strength by silica–manganese slag was 17.64% and 11.85%, respectively. The minimum loss of compressive strength after 75 cycles was 9.954%, which was 34.96% lower than that of the basic group. An analysis of the data showed that the optimal substitution rate of silica–manganese slag is 10%. It was observed by means of electron microscope scanning that the matrix structure was denser and had less connected pores and that the most complete hydration reaction occurred with a 10% replacement of silica–manganese slag, where an increase in the number of bladed tobermorite and flocculated C-S-H gels was observed to form a three-dimensional reticulated skeleton structure. We decided to use strength damage as a variable, and the two-parameter Weibull theory was chosen to model the damage. The final comparison of the fitted data with the measured data revealed that the model has a good fitting effect, with a fitting parameter above 0.916. This model can be applied in real-world projects and provides a favorable basis for the study of damage to silica–manganese slag concrete under the action of salt freezing.
Strength Model for Prestressed Concrete Beams Subjected to Pure Torsion
Authors: Ju Hyunjin , Jung Chanseo , Cho Hae-Chang
Published: August 2024

A torsional strength model for prestressed concrete beams was proposed considering the initial crack angle, principal stress angle, and longitudinal strain, which are affected by the axial stress induced by the effective prestress. The use of the torsional effective thickness was also proposed to calculate the torsional strength of prestressed concrete beams by considering the effect of prestress. The shear element in the torsional member was simplified under the assumption that the principal tensile stress and principal compressive strain were negligible in the ultimate state. The torsional strength was determined when the principal compressive stress or shear stress at the crack surface in the shear element reached the failure criterion according to the multipotential capacity model, which considers concrete crushing and aggregate interlocking as the main resistances to the applied load. The proposed strength model was verified using test specimens collected from existing experimental studies. The proposed model accurately evaluated the torsional strength of prestressed concrete beam specimens, regardless of the key variables of the prestressed concrete specimens, where the mean value of the tested results to the calculated torsional strengths was 1.123, and the corresponding coefficient of variation was 17.7% for 104 prestressed concrete beam specimens, while the ACI 318-19 torsional design method gave the mean and coefficient of variation of 0.880 and 24.3%, respectively.
Oncologic Applications of Artificial Intelligence and Deep Learning Methods in CT Spine Imaging—A Systematic Review
Authors: Ong Wilson , Lee Aric , Tan Wei Chuan , Fong Kuan Ting Dominic , Lai Daoyong David , Tan Yi Liang , Low Xi Zhen , Ge Shuliang , Makmur Andrew , Ong Shao Jin , Ting Yong Han , Tan Jiong Hao , Kumar Naresh , Hallinan James Thomas Patrick Decourcy
Published: August 2024

In spinal oncology, integrating deep learning with computed tomography (CT) imaging has shown promise in enhancing diagnostic accuracy, treatment planning, and patient outcomes. This systematic review synthesizes evidence on artificial intelligence (AI) applications in CT imaging for spinal tumors. A PRISMA-guided search identified 33 studies: 12 (36.4%) focused on detecting spinal malignancies, 11 (33.3%) on classification, 6 (18.2%) on prognostication, 3 (9.1%) on treatment planning, and 1 (3.0%) on both detection and classification. Of the classification studies, 7 (21.2%) used machine learning to distinguish between benign and malignant lesions, 3 (9.1%) evaluated tumor stage or grade, and 2 (6.1%) employed radiomics for biomarker classification. Prognostic studies included three (9.1%) that predicted complications such as pathological fractures and three (9.1%) that predicted treatment outcomes. AI’s potential for improving workflow efficiency, aiding decision-making, and reducing complications is discussed, along with its limitations in generalizability, interpretability, and clinical integration. Future directions for AI in spinal oncology are also explored. In conclusion, while AI technologies in CT imaging are promising, further research is necessary to validate their clinical effectiveness and optimize their integration into routine practice.
Expression Analysis of Circulating microRNAs in Saliva and Plasma for the Identification of Clinically Relevant Biomarkers for Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders
Authors: Rocchetti Federica , Tenore Gianluca , Macali Federica , Vicidomini Teresa , Podda Gian Marco , Fantozzi Paolo Junior , Silvestri Valentina , Porzio Virginia , Valentini Virginia , Ottini Laura , Richetta Antonio Giovanni , Valentini Valentino , Della Monaca Marco , Grenga Camilla , Polimeni Antonella , Romeo Umberto
Published: August 2024

This study aims to evaluate the expression of salivary and plasmatic miRNAs as diagnostic biomarkers in patients with oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs). A total of 25 patients were divided into three groups, according to their diagnosis: OSCC patients (n = 14); OPMDs patients (n = 6); and healthy controls (n = 5). At the time at diagnosis/enrolment, patients underwent salivary and plasmatic collection. The expression of miRNA -21, -31, -138, -145, -184, and -424 were evaluated by real-time PCR. An F-test and ANOVA test were performed to evaluate the miRNA levels (significance at p < 0.05). By comparing miRNA expression levels from saliva, a statistically significant difference emerged in the expression of miR-138 and miR-424 between the three groups (p < 0.05). In particular, these two miRNAs showed decreased expression levels in saliva samples from OSCC and OPMD patients compared to those from healthy controls. On the other hand, miRNA expression levels in plasma were low in all the groups, and no statistically significant differences were found. Overall, our results showed that liquid biopsy from saliva may be a useful tool for the identification of diagnostic molecular biomarkers in OSCC and OPMDs.
Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) for Gastric Cancer Peritoneal Metastases: Results from the Lithuanian PIPAC Program
Authors: Luksta Martynas , Bausys Augustinas , Gendvilaite Neda , Bickaite Klaudija , Rackauskas Rokas , Paskonis Marius , Luksaite-Lukste Raminta , Ranceva Anastasija , Stulpinas Rokas , Brasiuniene Birute , Baltruskeviciene Edita , Lachej Nadezda , Bausiene Juste , Poskus Tomas , Bausys Rimantas , Tulyte Skaiste , Strupas Kestutis
Published: August 2024

Background: Peritoneal metastases (PM) of gastric cancer (GC) are considered a terminal condition, with reported median survival ranging from 2 to 9 months. Standard treatment typically involves systemic chemotherapy alone or combined with targeted therapy or immunotherapy, though efficacy is limited. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has emerged as a novel technique for treating GC PM, although it remains an experimental treatment under investigation. This study aimed to summarize the outcomes of GC PM treatment with PIPAC from the Lithuanian PIPAC program. Methods: All patients who underwent PIPAC for GC PM at Vilnius University Hospital Santaros Klinikos between 2015 and 2022 were included in this retrospective study. The safety of PIPAC was assessed by postoperative complications according to the Clavien–Dindo classification. Efficacy was evaluated based on the peritoneal carcinomatosis index (PCI), ascites dynamics throughout the treatment, and long-term outcomes. Results: In total, 32 patients underwent 71 PIPAC procedures. Intraoperative and postoperative morbidity related to PIPAC occurred after three (4.2%) procedures. Following PIPAC, there was a tendency towards a decrease in median PCI from 10 (Q1 3; Q3 13) to 7 (Q1 2; Q3 12), p = 0.75, and a decrease in median ascites volume from 1300 mL (Q1 500; Q3 3600) at the first PIPAC to 700 mL (Q1 250; Q3 4750) at the last PIPAC, p = 0.56; however, these differences were not statistically significant. The median overall survival after PM diagnosis was 12.5 months (95% CI 10–17), and the median survival after the first PIPAC procedure was 5 months (95% CI 4–10). Conclusions: PIPAC is a safe and feasible treatment option for GC PM; however, well-designed prospective studies are needed to fully assess its efficacy.
Single-Port Extraperitoneal vs. Multiport Transperitoneal Robot-Assisted Radical Prostatectomy: A Propensity Score-Matched Analysis
Authors: Chavali Jaya S. , Pedraza Adriana M. , Soputro Nicolas A. , Ramos-Carpinteyro Roxana , Mikesell Carter D. , Kaouk Jihad
Published: August 2024

(1) Background: Since the introduction of the purpose-built Single Port (SP) robotic platform, there has been an ongoing debate regarding its advantages compared to the established multi-port (MP) system. The goal of this present study is to compare the perioperative, oncological, and functional outcomes of SP Extraperitoneal robotic radical prostatectomy (RARP) versus that of MP Transperitoneal RARP approach at a high-volume tertiary center. (2) Methods: Based on a retrospective review of the prospectively maintained IRB-approved database, 925 patients successfully underwent RARP by a single experienced robotic surgeon. A 4:1 propensity-matched analysis based on the baseline prostate cancer International Society of Urological Pathology (ISUP) Grade Group, clinical stage, and preoperative Prostate Specific Antigen (PSA) was performed, which yielded a cohort of 606 patients—485 in the SP EP and 121 in the MP TP approaches. Of note, the SP EP approach also included the traditional Extraperitoneal (n = 259, 53.4%) and the novel Transvesical (TV) approaches (n = 226, 46.6%). (3) Results: The overall operative time was slightly longer in the SP cohort, with a mean of 198.9 min compared to 181.5 min for the MP group (p < 0.001). There were no intraoperative complications with the MP approach and only one during the SP approach. The SP EP technique demonstrated significant benefits, encompassing reduced intraoperative blood loss (SP 125.1 vs. MP 215.9 mL), shorter length of hospital stay (SP 12.6 vs. MP 31.9 h), reduced opioid use at the time of discharge (SP 14.4% vs. MP 85.1%), and an earlier Foley catheter removal (SP 6 vs. MP 8 days). From an oncological perspective, the rate of positive surgical margins remained comparable across both groups (p = 0.84). Regarding functional outcomes, the mean continence rates and Sexual Health Inventory for Men (SHIM) scores were identical between the two groups at 6 weeks, 3 months, and 6 months respectively. (4) Conclusion: SP EP RARP demonstrates similar performance to MP TP RARP in terms of oncologic and functional outcomes. However, SP EP RARP offers several advantages in reducing the overall hospital stay, decreasing postoperative pain and hence the overall opioid use, as well as shortening the time to catheter removal, all of which translates to reduced morbidity and facilitates the transition to outpatient surgery.
Research Progress of Pt-Based Catalysts toward Cathodic Oxygen Reduction Reactions for Proton Exchange Membrane Fuel Cells
Authors: Chen Yue , Huang Zhiyin , Yu Jiefen , Wang Haiyi , Qin Yukuan , Xing Lixin , Du Lei
Published: August 2024

Proton exchange membrane fuel cells (PEMFCs) have been considered by many countries and enterprises because of their cleanness and efficiency. However, due to their high cost and low platinum utilization rate, the commercialization process of PEMFC is severely limited. The cathode catalyst layer (CCL) plays an important role in manipulating the performance and lifespan of PEMFCs, which makes them one of the most significant research focuses in this community. In the CCL, the intrinsic activity and stability of the catalysts determine the performance and lifetime of the catalyst layer. In this paper, the composition and working principle of the PEMFC and cathode catalyst layer are briefly introduced, focusing on Pt-based catalysts for oxygen reduction reactions (ORRs). The research progress of Pt-based catalysts in the past five years is particularly reviewed, mainly concentrating on the development status of emerging Pt-based catalysts which are popular in the current research field, including novel concepts like phase regulation (intermetallic alloys and high-entropy alloys), interface engineering (coupled low-Pt/Pt-free catalysts), and single-atom catalysts. Finally, the future research and development directions of Pt-based ORR catalysts are summarized and prospected.
Engineered CoS/Ni3S2 Heterointerface Catalysts Grown Directly on Carbon Paper as an Efficient Electrocatalyst for Urea Oxidation
Authors: Aladeemy Saba A. , Arunachalam Prabhakarn , Al-Mayouf Abdullah M. , Sudha P. N. , Rekha A. , Vidhya A. , Hemapriya J. , Latha Srinivasan , Prasad P. Supriya , Pavithra S. , Arunadevi Raja , Hameed Salah T.
Published: August 2024

Developing highly efficient and stable electrocatalysts for urea electro-oxidation reactions (UORs) will improve wastewater treatment and energy conversion. A low-cost cobalt sulfide-anchored nickel sulfide electrode (CoS/Ni3S2@CP) was synthesized by electrodeposition in DMSO solutions and found to be highly effective and long-lasting. The morphology and composition of catalyst surfaces were examined using comprehensive physicochemical and electrochemical characterization. Specifically, CoS/Ni3S2@CP electrodes require a potential of 1.52 volts for a 50 mA/cm2 current, confirming CoS in the heterointerface CoS/Ni3S2@CP catalyst. Further, the optimized CoS/Ni3S2@CP catalyst shows a decrease of 100 mV in the onset potential (1.32 VRHE) for UORs compared to bare Ni3S2@CP catalysts (1.42 VRHE), demonstrating much greater performance of UORs. As compared to Ni3S2@CP, CoS/Ni3S2@CP exhibits twofold greater UOR efficiency as a result of a larger electroactive surface area. The results obtained indicate that the synthetic CoS/Ni3S2@CP catalyst may be a favorable electrode material for managing urea-rich wastewater and generating H2.