bluuebunny/crossref_metadata_2025 huggingface dataset:
A Case Study in the Development of Fibrinolytic Therapy in a Community Hospital in Indonesia
Authors: Purawijaya Handrian , Anjelin Isabella
Published: May 2023

ABSTRACT Coronary heart disease (CHD) is one of the leading causes of mortality in Indonesia aside from stroke. To reduce the mortality rate, a highly time-dependent, adequate therapy is needed for patients with electrocardiographic features of ST-Elevation Myocardial Infarction (STEMI). The gold standard for reperfusion therapy is thirty minutes for fibrinolytics and ninety minutes for primary PCI. For a community hospital, conducting the reperfusion therapy can be a challenge due to various factors, including human resources, standard operating procedures, and the infrastructure needed. However, to refer the patient to a tertiary hospital often requires time longer than ninety minutes. Therefore, community hospitals should be able to act as the front line of the healthcare system by facilitating fibrinolytic therapy to reduce the mortality rate of CHD in Indonesia. Development of fibrinolytics treatment in community hospitals can be done by creating an expert-reviewed SOP, providing competent human resources, and equipping the hospital with the necessary infrastructure for the service. These are all done in order to keep up with the "golden period" of STEMI patients with a thirty-minute door-to-needle timeframe and reduce the mortality rate caused by ACS in Indonesia. Keywords: Community Hospital, CHD, STEMI, Fibrinolytics.  ABSTRAK Penyakit jantung koroner (PJK) merupakan salah satu penyebab utama kematian di Indonesia selain stroke. Untuk mengurangi angka kematian, terapi yang sangat tergantung waktu dan memadai diperlukan untuk pasien dengan fitur elektrokardiografi ST-Elevation Myocardial Infarction (STEMI). Standar emas untuk terapi reperfusi adalah tiga puluh menit untuk fibrinolitik dan sembilan puluh menit untuk PCI primer. Untuk rumah sakit komunitas, melakukan terapi reperfusi dapat menjadi tantangan karena berbagai faktor, termasuk sumber daya manusia, prosedur operasi standar, dan infrastruktur yang dibutuhkan. Namun, untuk merujuk pasien ke rumah sakit tersier seringkali membutuhkan waktu lebih dari sembilan puluh menit. Oleh karena itu, rumah sakit komunitas harus mampu berperan sebagai garda terdepan dalam sistem pelayanan kesehatan dengan memfasilitasi terapi fibrinolitik untuk menurunkan angka kematian PJK di Indonesia. Pengembangan pengobatan fibrinolitik di rumah sakit komunitas dapat dilakukan dengan membuat SOP yang ditinjau oleh ahli, menyediakan sumber daya manusia yang kompeten, dan melengkapi rumah sakit dengan infrastruktur yang diperlukan untuk pelayanan. Ini semua dilakukan untuk mengimbangi “masa emas” pasien STEMI dengan timeframe door-to-needle tiga puluh menit dan menekan angka kematian akibat SKA di Indonesia. Kata Kunci: RS Komunitas, PJK, STEMI, Fibrinolitik.
Perbedaan Pertumbuhan Bayi Usia 0-6 Bulan yang Mendapat Asi Ekslusif dan Asi Non Ekslusif di UPTD Puskesmas Langsa Timur
Authors: Surnimawati Surnimawati , Tindaon Rotua Lenawati , Marlina Teti , Tasya Tasya , Suryati Suryati , Aulia Tia
Published: May 2023

ABSTRACT Based on UNICEF data in 2020, three regions have a very high prevalence of growth disorders, with around a third of children affected. The aim of the study was to determine the differences in the growth of infants aged 0-6 months who were exclusively breastfed and non-exclusively breastfed. What will be carried out by the East Langsa Health Center UPTD will be held on April 26-November 2022. The entire population is taken as a sample, namely 30 people. The design of this study is descriptive analytic, with a cross sectional approach using data analysis using the Chi-Square test method to test hypotheses with the help of SPSS. Based on the calculation results of the Chi-Square Statistical Test method, a p-value of 0.042 ± 0.05 was obtained, meaning that Ho was accepted and Ha was rejected so that it could be concluded that there were differences in the growth of infants aged 0-6 months who received exclusive breastfeeding with non-exclusive breastfeeding. The results of the statistical test also obtained an OR value of 7.857, meaning that babies who were not given exclusive breastfeeding had an 8 times greater chance of experiencing poor growth than babies who were given exclusive breastfeeding Keywords: Infant Growth, Exclusive Breastfeeding, Non-Exclusive Breastfeeding  ABSTRAK Berdasarkan data UNICEF pada tahun 2020 tiga wilayah memiliki pravalensi penyimpangan pertumbuhan yang sangat tinggi, dengan sekitar sepertiga anak terkena dampaknya. Tujuan penelitian mengetahui perbedaan pertumbuhan bayi usia 0-6 bulan yang mendapatkan ASI ekslusif dengan ASI non ekslusif. Yang akan dilaksanakan UPTD Puskesmas Langsa Timur, diadakan pada 26 April-November 2022. Semua populasi dijadikan sampel yaitu 30 orang. Desain penelitian ini adalah deskriptif anaSlitik, dengan metode pendekatan cross sectional menggunakan analisa data metodsse Chi-Square test untuk menguji hipotesa dengan bantuan SPSS. Berdasarkan hasil perhitungan metode Uji statistic Chi- Square, diperoleh nilai p-value sebesar 0,042 0,05 artinya Ho diterima dan Ha ditolak sehingga dapat disimpulkan bahwa terdapat perbedaan pertumbuhan bayi usia 0-6 bulan yang mendapatkan ASI eksklusif dengan ASI non eksklusif. Hasil Uji statistik juga memperoleh nilai OR 7,857 artinya bayi yang tidak diberikan ASI Eksklusif memiliki peluang 8 kali lebih besar mengalami pertumbuhan yang tidak baik dari pada bayi yang diberikan ASI Eksklusif.kata kunci: Pertumbuhan Bayi, ASI Ekslusif, ASI non Ekslusif
Hubungan Kebutuhan Perawatan Bayi BBLR di Rumah dengan Pendekatan Family Centered Maternity Care di Puskesmas Lhok Kruet Aceh Jaya
Authors: Siregar Efrida Yanti , Aminah Aminah , Suharti Dewiana , Turnip Jayanti , Suryana Herni
Published: May 2023

ABSTRACT Low birth weight, commonly referred to as LBW, remains a major problem in infant mortality in Indonesia. Mother's skills for optimal care for low birth weight babies by using educational experiences, discussions, as well as technology for stunting prevention learning media to increase mother's knowledge and confidence to care for babies with low birth weight can be strengthened through Family- Centered Maternal Care (FCMC), which is care focused on a family that provides care to women and their families, integrating pregnancy, childbirth and infant care into the chain of family life. FCMC was implemented to improve self-care and newborn care skills. The purpose of this study is to find out whether there is a relationship between the care needs of LBW infants at home and the FMCM approach. This research will use a descriptive method with a cross sectional approach, will be carried out at the Lhok Kruet Health Center, Kec. Sampoiniet Kab. Aceh Jaya, held in July 2022. All populations were sampled, namely 30 mothers, the type of research was descriptive with a cross sectional approach. The results of the chi square test obtained a p-value of 0.002 (p<α) 0.05, namely Ho is rejected and Ha is accepted, the conclusion is that there is a relationship between the care needs of LBW babies at home with the Family Centered Maternity Care approach at the Lhok Kruet Health Center Aceh Jaya 2022.  Keywords: Needs, LBW, Family Centered Maternity Care  ABSTRAK Berat bayi lahir rendah yang biasa disebut sebagai BBLR tetap menjadi masalah utama kematian bayi di Indonesia. Kemahiran ibu agar perawatan optimal pada BBLR dengan menggunakan pengalaman pendidikan, diskusi, juga teknologi untuk media pembelajaran pencegahan stunting untuk bertambahnya pengetahuan dan kepercayaan diri ibu untuk merawat bayi dengan berat badan kurang dapat diperkuat melalui Family-Centered Maternal Care (FCMC) ialah perawatan berfokus terhadap keluarga yang memberikan perawatan kepada wanita serta keluarganya, menyatukan kehamilan, persalinan dan perawatan bayi ke dalam rantai kehidupan keluarga. FCMC diimplementasikan supaya meningkatkan keterampilan perawatan diri dan perawatan bayi baru lahir. Tujuan penelitian ini agar mengetahui adakah hubungan kebutuhan perawatan bayi BBLR di rumah dengan pendekatan FMCM?. Pada penelitian ini akan menggunakan metode deskriptif dengan pendekatan cross sectional, akan dilaksanakan di Puskesmas Lhok Kruet Kec. Sampoiniet Kab. Aceh Jaya, diadakan pada Juli 2022. Semua populasi dijadikan sampel yaitu 30 orang ibu, jenis penelitan yaitu deskriptif dengan pendekatan cross sectional. Hasil uji chi square diperoleh nilai p-value 0,002 (p<α) 0,05 yaitu Ho ditolak dan Ha diterima, kesimpulannya terdapat hubungan kebutuhan perawatan bayi BBLR di rumah dengan pendekatan Family Centered Maternity Care di Puskesmas Lhok Kruet Aceh Jaya 2022. Kata Kunci: Kebutuhan, BBLR, Family Centered Maternity Care
«ІНШИЙ/ЧУЖИЙ»: ОБРАЗ ЄВРЕЇВ У СПОГАДАХ УКРАЇНСЬКИХ СУСІДІВ ПРО ДРУГУ СВІТОВУ ВІЙНУ»
Authors: Долганов Петро
Published: May 2023

Статтю присвячено аналізу свідчень українських очевидців про події Голокосту на теренах Західної Волині. Більшість свідчень було записано в межах реалізації усноісторичного проєкту «Голоси» впродовж 2020–2021 рр. У цих свідченнях оприявнюється чимало стереотипних уявлень українських селян про євреїв. Ще від рубіжної для студій Голокосту дискусії поміж Д.  Ґольдгаґеном та К. Браунінгом чимало дослідників дискутують про те, який вплив міг здійснювати антисемітизм на поведінку неєврейського населення під час Голокосту.

Стаття демонструє, що чимало представників християнського населення Волині під час Другої світової війни були носіями традиційних антисемітських упереджень і стереотипів. Більшість цих стереотипів розділено на ті, що мають соціально-економічний вимір, та  стереотипи релігійного походження. Перші випливають із наявного в регіоні етнокультурного поділу праці, в умовах якого більшість українців працювали в аграрному секторі, тоді як євреї були ремісниками, торговцями, лікарями, юристами тощо. Попри те, що на території Західної Волині чимало євреїв теж працювали в аграрному секторі й мешкали в сільській місцевості, українські селяни все одно виношували чимало стереотипів про «єврея-торговця», який не любить працювати, а заробляє на життя «хитрістю» чи «обманом». Часто саме нерозуміння специфіки торгової сфери породжувало в багатьох українських селян-аграріїв уявлення про «невиробничий» характер професії торговця. Воно призводило до переконання в тому, що більшість євреїв «хитрі» й отримують прибуток, не докладаючи великих зусиль. Звідси випливало ще одне міфологічне переконання про казкові багатства навіть позірно бідних євреїв (чимало селян були переконані, що вони мають заховані золоті скарби).

Релігійні ж стереотипи про євреїв випливали з християнської культури, в якій ще з середньовіччя усталилося переконання про те, що євреї «винні» у вбивстві Ісуса Христа. У зв’язку з цим окремі українські селяни були схильні обґрунтовувати причини Голокосту «покаранням» за тисячолітні гріхи єврейських предків перед Ісусом. Зважаючи на те, що більшість оповідачів належали до числа малограмотних селян, які мали переважно початкову освіту, їм виявилися не близькі модерні ідеологічні міфи про «жидо-більшовизм», які так ревно поширювалися нацистською пропагандою. Якою мірою традиційні антисемітські уявлення українських селян могли впливати на їхню поведінку під час Голокосту судити важко. Найімовірніше вони могли позначатися на схильності до емпатії окремих єврейських сусідів та їх готовності прийти на допомогу. Проте цей чинник навряд чи мав вирішальний вплив на формування соціальної динаміки геноциду.
ХТО БОЇТЬСЯ УКРАЇНСЬКОГО НАЦІОНАЛІЗМУ?
Authors: Макбрайд Джаред , Шаталов Денис
Published: May 2023

Рецензія на книги:• Grzegorz Rossoliński-Liebe, Stepan Bandera: The Life and Afterlife of a Ukrainian Nationalist. Fascism, Genocide, and Cult. Stuttgart: Іbidem, 2014.• Myroslav Shkandrij, Ukrainian Nationalism: Politics, Ideology, and Literature, 1929–1956. New Haven: Yale University Press, 2015.• Володимир В’ятрович, Друга польсько-українська війна 1942–1947. Київ: Видавничий дім «Києво-Могилянська академія», 2011.
Application of Fractional $SPR$ Psychological Disease Model in Turkey and Stability Analysis
Authors: ÖZTÜRK Zafer , BİLGİL Halis , SORGUN Sezer
Published: May 2023

Psychological diseases and their treatment are problems related to public health. According to data from the World Health Organization, about a billion people have either mental illness or substance use disorder problems in 2017. Mental, neurological diseases and substance use disorders account for 30 percent of the global non-fatal disease burden and 10 percent of the global disease burden. It is noted that in the world Dec 2005 and 2015, the incidence of mental health diseases increased by about 16 percent. In this study, we have created a fractional-order mathematical modeling for the population of individuals suering from psychological diseases in a society. In this model, the total population was divided into three compartments: individuals who did not receive psychological treatment (S), individuals who received psychological support (P) and individuals who recovered after completing psychological treatment (R). As a fractional derivative, we used the Caputo derivative definitions. Numerical solutions were obtained with the help of Euler method by performing stability analysis related to the fractional SPR model created for the mathematical model of psychological patients. Thus, it was interpreted by creating dynamics for the number of individuals with psychological problems
in a population.
TRANSPOSIÇÃO DIDÁTICA: UM OLHAR PARA O ENSINO DA FÍSICA
Authors: Carneiro André Tarcisio , Prado Suzana Pereira do
Published: May 2023

Este texto discute por meio de uma pesquisa bibliográfica alguns enfoques da Teoria da Transposição Didática (TD), em especial a transposição didática interna e a sobrevivência dos saberes no âmbito do ensino da Física. Buscou-se reconhecer a importância de refletir sobre o processo de construção do saber a ensinar, bem como as adaptações e aproximações estabelecidas pela noosfera. Para tanto, trouxemos uma definição de Transposição Didática em Chevallard e sua abordagem na Física através de Brockington e Pietrocola. Concluímos que é possível a aplicabilidade da TD em contextos para além da Matemática, porém, ainda existem alguns obstáculos referentes ao tempo didático e por vezes em torno da própria noosfera, o que pode impactar no processo de aprendizagem.    
Palavras-chave: Transposição Didática. Física. Ensino. Aprendizagem.
 
ABSTRACT
This text discusses, through a bibliographical research, some approaches of the Didactic Transposition Theory (DT), in particular the internal didactic transposition and the survival of knowledge within the scope of Physics teaching. We sought to recognize the importance of reflecting on the process of building knowledge to teach, as well as the adaptations and approximations established by the noosphere. For that, we brought a definition of Didactic Transposition in Chevallard and its approach in Physics through Brockington and Pietrocola. We conclude that the applicability of DT in contexts beyond the Mathematics, however, there are still some obstacles related to didactic time and sometimes around the noosphere itself, which can impact the learning process. 
Keywords: Didactic Transposition. Physical. Teaching. Learning.
Manifestações bucais do diabetes mellitus: uma revisão integrativa
Authors: Gonçalves Pedro Paullo Alves , Sampaio Joana D’arc da Silva , Freitas Núria Irina Gomes dos Reis , Raposo Rebeca Carvalho , Fonseca de Arruda Samira , Lago Marilia Leal Ferreira , Cantanhede Luana Martins
Published: May 2023

O Diabetes Mellitus (DM) é uma doença crônica caracterizada pela insuficiência de insulina não produzida pelo pâncreas ou pela incapacidade do corpo de usá-la podendo acarretar em hiperglicemia. As alterações metabólicas decorrentes do DM descompensado geram consequências em todo o corpo, consequentemente afetando a saúde bucal também. Portanto, é imprescindível que os cirurgiões-dentistas conheçam essas manifestações a fim de proporcionar um melhor tratamento odontológico. Nesse sentido, o objetivo desse estudo foi descrever as principais manifestações bucais associadas ao diabetes mellitus por meio de uma revisão integrativa da literatura. Assim, realizou-se uma busca nas bases de dados PubMed/Medline, Lilacs e SciELO chegando à seleção final de 12 artigos para este trabalho. Os resultados revelaram uma alta prevalência de alterações bucais como xerostomia, cárie dentária, doença periodontal e estomatite em pacientes com DM. Dessa forma, constatou-se que o DM está associado a manifestações bucais como alterações salivares, dentais, periodontais e em tecidos moles. Portanto, fica clara a importância do cirurgião-dentista no diagnóstico precoce e/ou controle das possíveis complicações associadas ao DM.
RISKS ANALYSIS IN CATERING INDUSTRY
Authors: ANKARALIGİL Tolga , ÖZDEMİR Ayşe
Published: May 2023

In recent years, the occupational health and safety has become one of the important elements of working life. The importance of contributing to the protection of employee health by preventing occupational accidents and occupational diseases is increasing demand nowadays. The rapid growth of the catering sector with increasing employment and competition turn into a growing problem: increase in occupational accidents. In this research carried out with the necessity of taking precautions for the solution of this problem; A risk analysis was conducted in a catering company in Uşak to identify hazards and risks in the company.  The hazards and risks are evaluated and precautionary actions were determined according to the current situation. At the same time, it is thought to be beneficial in terms of creating awareness for all companies in the sector by contributing to the protection of employee health by reducing occupational accidents and diseases. Risk analyses were done by L type matrix (5x5 matrix table). In this study, a total of 131 hazards and risks were identified. The identified hazards and risks are grouped according to their risk level (Unacceptable risk: 5; Significant risk:61; Medium risk:59). It is considered that adopting proactive approaches within the scope of occupational safety practices will accelerate the spread of the safety network and occupational safety culture to all employees
IMMUNOHISTOCHEMICAL ANALYSIS OF SFLT-1 AND ADAMTS-8 EXPRESSION IN DIABETIC RAT TESTIS TISSUE
Authors: KAYA Seval , NERGİZ Yusuf , ASIR Fırat , GÖKALP ÖZKORKMAZ Ebru , ERDOGAN Gamze , DEVECİ Engin
Published: May 2023

Abstract: The aim of this study was to determine the testicular inflammation
and angiogenetic effect of diabetes with ADAMTS-8 and SFlt-1 proteins
immunohistochemically. Wistar albino male rats (n: 12)were used for the study,
Group 1: Control group (n: 6), only 1 ml i.p. saline injection was performed.
Group 2: Diabetes group (n: 6) received a single intraperitoneal dose of
streptozotocin (STZ) of 60 mg / kg. The glucose value measured above 250 mg /
dl was considered as diabetic. Under anesthesia, dissection was performed at
the lower part of abdominal clearance and testicular tissue was removed. Testis
tissues were fixed in 10% neutral formalin, followed by the routine paraffin
protocol and cut with a microtome. Then, primary antibodies (ADAMTS-8, sFlt-1)
were applied by immunohistochemistry method and incubated at +4 ˚C overnight.
The sections were then examined under a light microscope.

Diabetes
group showed that Leydig cells in the  inter tubular area had vacuolization and
capillary dilatations in histopathological examinations. sFlt-1 staining of
control group showed positive expression in capillary endothelium between
Leydig chambers of the intertubular area. Sflt-1 expression of diabetes group
was observed in degenerative spermatic cells and Sertoli cells of the basement
membrane facing tubules. The expression of ADAMTS-8in control group was
positive in some Leydig cells in the interstitial area of Sertoli cells in
seminiferous tubule but, spermatogenetic cells were negative. In the ADAMTS-8
staining of diabetes group, the expression of ADAMTS-8 was increased in the
stromal cells and some inflammatory cells in the intertubular space. SFlt-1 plays a crucial role in angiogenesis
as well as in diabetic testes and is marked as a precursor for the disruption
of vascular structure and blood flow due to degenerative changes. It is thought
that the distribution of ADAMTS-8 may be a determinant protein in the
development of extracellular matrix and in damage to testicular tissue of
diabetic testis.
Yazılım Dağıtım Sürecinin Otomatikleştirilmesine İlişkin Uygulamalı Bir Çalışma
Authors: ŞAHİNASLAN Ender , ARPACIOĞLU Nusret , ŞAHİNASLAN Önder
Published: May 2023

Yazılım dağıtımı, geliştirilen bir uygulamanın çalıştırılacak dijital ortamlara yüklenmesidir ve yazılım geliştirme yaşam döngüsünde önemli bir aşamadır. Herhangi bir hataya veya kesintiye yol açmayacak şekilde titizlikle uygulanmalıdır. Küçük organizasyon ve sistemlerde bu sürecin işleyişinin manuel olarak işletilebilmesi mümkündür. Ancak orta ve büyük organizasyonlarda dağıtım yapılacak ortamların çeşitliliği, büyüklüğü, karmaşıklığı buna engeldir. Ayrıca iş sürekliliği, güvenlik ve uyum gibi gereksinimler dikkate alındığında manuel dağıtımdan kaynaklı birçok risk söz konusudur. Bu tür risk ve sorunların aşımında otomatik yazılım dağıtım araçlarına ihtiyaç vardır. Bu çalışmada yazılım yaşam ve dağıtım süreci, manuel dağıtımdan kaynaklı sorunlar, sorunların çözümünde kullanılan otomatik dağıtım araçları incelenmiştir. Yazılım dağıtım sürecinin otomatikleştirilmesi uygulamalı olarak çalışılmıştır. Bu çalışma daha önce yapılan çalışmalardan farklı olarak, konusu ve uygulamalı bir sunum olması sebebiyle ilgili kurum çalışanları, öğrenci ve araştırmacılar için teknik bir rehber niteliğindedir. Yazılım dağıtım süreci ve bu sürecin otomatikleştirilmesine yönelik uygulamalı çalışma literatüre kazandırılmıştır.
NEW STUDENT CLUSTERIZATION BASED ON NEW STUDENT ADMISSION USING DATA MINING METHOD
Authors: Diana Anita , Ariesta Atik , Wibowo Arief , Risaychi Diva Ajeng Brillian
Published: May 2023

The process of admitting new students to the Faculty of Information Technology (FTI) at Universitas Budi Luhur produces a large amount of student data in the form of student profile data and other data. This happens causing a buildup of new student data, thus affecting the search for information on that data. This study aims to classify regular undergraduate admissions data at the Faculty of Information Technology (FTI) Universitas Budi Luhur by utilizing the data mining process using the clustering technique. The algorithm used for clustering is the K-Means algorithm. K-Means is a non-hierarchical clustering data method that can group student data into several clusters based on the similarity of the data, so that student data with the same characteristics is grouped in one cluster and those with different characteristics are grouped in another cluster. An implementation using RapidMiner is used to help find accurate values. This research produced a description of what clusters were formed from data on regular undergraduate admissions at the Faculty of Information Technology (FTI) at Universitas Budi Luhur. This will help recommend decision-making to determine the marketing promotion strategy for each study program at Universitas Budi Luhur. Based on the results of the K-Means algorithm cluster, it can also be seen which majors or study programs are of interest in each school from which new students come.
TANTANGAN DALAM PENYELESAIAN GUGATAN SEDERHANA
Authors: Agustini Shenti
Published: May 2023

Indonesia is a state of law. This is due to the existence of a fundamental judicial power that adheres to the principles of the administration of judicial power. One of the principles is the principle of simple, fast and low cost. This is manifested in the settlement of a simple lawsuit. The purpose of this study is to analyze the challenges of settling a simple lawsuit. The research method used is normative juridical and uses juridical and theoretical foundations in analyzing this research. The theory used is the Theory of Legal Certainty by Gustav and Theory of Legal Systems by Lawrence. The results of the study, it was found that Indonesia has provided legal certainty in the settlement of simple lawsuits by stipulating this in PERMA Number 4 of 2019. However, its application still varies based on obstacles caused by legal culture.
Refining capture-recapture recruitment estimation methods for Atlantic sturgeon
Authors: Baker MA , Ingram EC , Higginbotham DL , Irwin BJ , Fox AG
Published: May 2023

The Atlantic sturgeon Acipenser oxyrinchus oxyrinchus was once of great commercial importance in many coastal rivers of the eastern USA. Over the 19th and 20th centuries, most historical stocks of Atlantic sturgeon were depleted by human activities. Estimating recruitment for the remaining populations is challenging due to sampling constraints, limited age data, and natural variability. However, recruitment estimates could inform recovery efforts. The objectives of this study were to compare 2 modeling approaches to estimate recruitment of age-1 Atlantic sturgeon and provide an updated index of abundance across more than a decade of sampling in the Altamaha River, Georgia. First, we constructed capture histories of river-resident juveniles, using capture-mark-recapture data collected from 2008 to 2020, and assigned ages based on length-frequency analysis. Second, we compared more traditional Huggins closed population models and a recent nonlinear extension of Huggins models—vector generalized additive models (VGAMs)—to estimate abundance of age-1 fish. Both model types indicated similar yearly age-1 abundance estimates (Huggins: 163 in 2017 to 3839 in 2010; VGAM: 312 in 2020 to 4448 in 2010), but the VGAMs provided more direct interpretation for factors that might affect capture probability (e.g. sampling effort, temperature, fish length). This study indicates that the age-1 Altamaha River Atlantic sturgeon population has remained relatively stable over the past decade and provides a long-term baseline which will better enable managers to assess the effects of either future restoration actions or environmental disturbances on the population.
ANALISIS KESIAPAN PEMERINTAH DESA DALAM PENGELOLAAN KEUANGAN DAN ASET DESA
Authors: Nuna Muten , Tumuhulawa Arifin , Sahi Nirmala A , Pauweni Lisnawati , Biongan Ahiar
Published: May 2023

The problems faced by the Village Government of Panca Karsa I Taluditi District are related to the management of village finances and village assets. Among them, the readiness of the Human Resources (HR) owned by the Panca Karsa I Village Government in managing village finances and assets. This is also due to the unpreparedness of the village officials in line with developments and changes in regulations and also the lack of reliable human resources in their fields. This qualitative descriptive research by prioritizing primary data and secondary data, focuses on seeing how prepared the village government is in managing village finances and assets, in Panca Karsa I Village, Taluditi District and what factors influence it? The conclusion is that the readiness of the village government of Panca Karsa I, Taluditi District, in general, is quite good, where the village government has a fairly good mental and emotional attitude, namely having the ability and great will to manage village finances and assets. The several factors that influence it are: organizational commitment, human resources and information systems.
KEBIJAKAN PENYELENGGARAAN REFORMASI BIROKRASI PADA PEMERINTAH KABUPATEN BEKASI
Authors: Kuswandi Aos , Nuraini Siti , Hartono Rina Susanti
Published: May 2023

In the development of the Indonesian government, bureaucratic reform has lagged behind reforms in the political, economic, and legal fields. The first wave of government bureaucratic reform was gradually implemented in 2004 and the second phase in 2010. In 2025, Indonesia is expected to be in a phase that is truly moving towards a developed country and the strength of a professional and high-integrity government bureaucracy. Efforts to achieve the goals of bureaucratic reform are carried out through the stipulation of Presidential Regulation no. 81 of 2010 concerning the Grand Design of Bureaucratic Reform 2010-2025, it is very necessary to be supported by the provincial and district/city governments. This study describes the results of research on the implementation of bureaucratic reform in the Bekasi Regency Government. The results of the study indicate that it is important for the Bekasi Regency Government to formulate and establish the Grand Design for Bureaucratic Reform as the master plan that contains the policy direction for implementing bureaucratic reform within the Bekasi district government. As an operational medium in the medium term, the Bureaucratic Reform Road Map needs to be drawn up and carried out every 5 (five) years and is a detailed plan for bureaucratic reform from one stage to the next for five years with clear annual targets. Bureaucratic reform in Bekasi Regency needs to revise and develop various regulations, modernize various government management policies and practices, and adapt the tasks of regional work unit functions to new paradigms and roles.
FENOMENA FLYPAPER EFFECT PADA PENGELOLAAN KEUANGAN DAERAH KABUPATEN DAN KOTA DI JAWA TIMUR
Authors: Linawati
Published: May 2023

Pemerintah daerah harus melakukan pengelolaan keuangan dengan baik. Diwujudkan dengan melakukan perencanaan penerimaan dan pengeluaran daerah yang efektif dan efisien. Penelitian ini bertujuan untuk menganalisis fenomena flypaper effect pada pengelolaan keuangan daerah Kota dan Kabupaten di Jawa Timur. Pengelolaan diproksikan dengan mengkaji pengaruh PAD dan DAU terhadap belanja daerah. Analisis menggunakan analisis regresi berganda. Hasil penelitian mendapatkan bukti bahwa Pendapatan Asli Daerah dan Dana Alokasi Umum secara parsial maupun simultan berpengaruh signifikan terhadap belanja daerah di Kota dan Kabupaten Di Jawa Timur. Hasil penelitian juga menemukan hasil bahwa tidak terjadi fenomena flypaper Effect pada kota dan kabupaten di Jawa Timur. Hal ini mengungkapkan bahwa pemerintah daerah Kota dan Kabupaten di Jawa timur tidak mengandalkan dana transfer dari pemerintah pusat  berupa DAU sebagai sumber pembiayaan untuk belanja daerahnya. Pemerintah daerah Kota dan Kabupaten di Jawa Timur ingin mewujudkan otonomi daerah yang kuat, dengan tingkat kemandirian daerah yang tinggi.
E-Recruitment BEM PSDKU Polinema Di Kota Kediri (Rekomendasi Pemilihan Kementrian Menggunakan Metode K-Nearest Neighbor)
Authors: Fadelis Sukya  , Isna Uswatun K  , Muhamad Efendi M
Published: May 2023

Open Recruitment is an activity that must be carried out every year by BEM PSDKU to recruit new members. So far, these activities are still carried out manually by collecting registration files and registration forms in hardfile form to the committee. So that the committee must check the participant's files one by one and it will take a long time. In addition, the risk of losing files is also very possible, even though registration data is important data for the implementation of the next selection. Another problem is that participants are often confused and hesitant to decide which ministry to choose when registering as a new member of the BEM. Usually to overcome this problem participants only consult directly with existing BEM members so that they get a recommendation for a ministry position that suits their interests or seek information independently on BEM social media.Therefore, it is necessary to develop an online Recruitment system for the Ministry's Recommendation section using the website-based K-Nearest Neighbor Method. The system is designed and implemented using PHP, MySQL, HTML, CSS, JavaScript, and Boostrap. This system has also been tested by several users and the result is that each user can process form data and participant registration files more easily and quickly. In addition, participants can also use the available decision support system to obtain recommendations from the ministry as a provision to register at the BEM.
Sistem Informasi Program Kerja ASLAB Berbasis Web (Studi Kasus GI-BEI PSDKU Polinema di Kota Kediri)
Authors: Yanda Muhammad Naufall. A  , Ellya Nufarida  , Agustono Heriadi
Published: May 2023

Data processing of work programs at the Indonesian Stock Exchange Investment Gallery Laboratory Assistant (ASLAB GI-BEI) belonging to the accounting department at the PSDKU Polinema campus in Kediri City is still running with a manual system. This work program data processing still uses paper to record the formation of the committee, attendance data and meeting minutes. Then for the work program data processing using the Microsoft Excel application to create reports. Work program data will not be effective if data recording is done manually. Besides being difficult, recording data manually using paper is very risky, such as damage and loss of recording books. Meanwhile, recording data using the Microsoft Excel application is also less efficient and effective, which allows redundancy and errors in writing data. Therefore, we need a website-based application that can manage data recording of work program activities with the aim of making it easier for ASLAB GI-BEI to process data on work program activities online. This work program information system is made in the Laravel Framework with PHP programming language and MySQL database. This activity information system has 3 users, namely Members, Chairpersons, and Supervisors. The application features consist of user management, application management, work program management, meeting management, committee management, and LPJ management.
Sistem Informasi Geografis Pemetaan Angka Gizi Buruk di Wilayah Kediri
Authors: Shofi Romal ‘Izzul ‘Ula  , Rinanza Zulmy Alhamri
Published: May 2023

Proses representasi pemetaan angka gizi buruk di wilayah Kediri belum menggunakan teknologi komputer, sehingga proses pemantauan angka gizi buruk pada setiap wilayah masih belum tersajikan dengan baik. Hal ini tentu mempersulit kerja dari kader maupun dinas Kehatan untuk memantau angka gizi buruk di Wilayah Kediri. Oleh karena itu, perlu dibangun sebuag sistem informasi yang mampu menyediakan data-data baik dalam bentuk grafik maupun peta untuk pemetaan angka gizi buruk di wilayah Kediri. Perancangan dan pembangunan sistem informasi ini dilakukan dengan menggunakan metode pengambilan data dan wawancara langsung kepada Dinas Kesehatan Kota dan Kabupaten Kediri, dengan mencari referensi lain terkait dengan penilitian yang serupa.

Tujuan dibangunnya Sistem Informasi Geografis Pemetaan Angka Gizi buruk di Wilayah Kediri adalah agar dapat membantu masyarakat dan Dinas Kesehatan dalam memantau serta menangani kasus gizi buruk di wilayah Kediri. Sistem Informasi Geografis ini akan menampilkan data gizi buruk berdasarkan kecamatan dengan menggunakan poligon warna sebagai tanda yang memberikan informasi mengenai keadaan yang aman atau keadaan yang membutuhkan penanganan lebih lanjut. Sistem yang dirancang akan diimplementasikan menggunakan framework laravel dengan bahasa pemrogaman yang digunakan adalah PHP, CSS, JavaScript, dan menggunakan database MySQL.
Analisis Securities Selection Skill dan Market Timing Ability pada Kinerja Reksadana Syariah Campuran di Bursa Efek
Authors: Dwiyana Marta , Nur Indah Riwajanti  , Fita Setiadi
Published: May 2023

Reksadana adalah media yang digunakan untuk mengumpulkan uang dari investor dan kemudian diinvestasikan dalam bentuk portofolio oleh manajer investasi. Penelitian ini bertujuan untuk mengukur kinerja manajer investasi reksadana syariah dengan menganalisis securities selection skill dan market timing ability berdasarkan model TreynorMazuy dan Henriksson-Merton. Data yang digunakan dalam penelitian ini adalah Nilai Aktiva Bersih, Sertifikat Bank Indonesia dan Jakarta Islamic Index. Populasi dalam penelitian ini adalah sembilan puluh tiga reksadana. Sampel diambil dengan menggunakan teknik purposive sampling. Sampel yang digunakan adalah tiga belas reksadana syariah yang terdaftar di Bursa Efek Indonesia dari 2014 hingga 2016. Penelitian ini menggunakan metode regresi yang diolah dengan menggunakan Eviews 7.0. Hasil penelitian menunjukkan bahwa berdasarkan Sharpe Ratio mengindikasikan bahwa dari tiga belas reksadana, hanya ada empat reksadana yang berkinerja baik sementara sembilan reksadana lainnya berkinerja buruk. Hasil berdasarkan model Treynor-Mazuy dan Henriksson-Merton mengindikasikan bahwa manajer investasi tidak memiliki securities selection skill dan market timing ability. Secara umum, temuan tersebut menunjukkan bahwa manajer investasi reksadana tidak memiliki kemampuan untuk memilih aset dari portofolio yang diharapkan untuk memberikan return dan tidak memiliki kemampuan untuk mengambil kebijakan yang tepat untuk membeli atau menjual sekuritas tertentu. Disarankan agar Otoritas Jasa Keuangan harus mengadakan pelatihan berkelanjutan untuk manajer investasi dan harus mengeluarkan sertifikasi baru khusus untuk manajer investasi dengan meningkatkan standar kompetensi.
Immunogenetics and pharmacogenetics of allergic asthma in Africa
Authors: Mabelane Tshegofatso , Masekela Refiloe , Dandara Collet , Hadebe Sabelo
Published: May 2023

Asthma is a common chronic condition in children and in an African setting is often highly prevalent in urban areas as compared to rural areas. Asthma is a heritable disease and the genetic risk is often exacerbated by unique localised environmental factors. The Global Initiative for Asthma (GINA) recommendation for the control of asthma includes inhaled corticosteroids (ICS) alone or together with short-acting β2-agonists (SABA) or long-acting β2-agonists (LABA). While these drugs can relieve asthma symptoms, there is evidence of reduced efficacy in people of African ancestry. Whether this is due to immunogenetics, genomic variability in drug metabolising genes (pharmacogenetics) or genetics of asthma-related traits is not well defined. Pharmacogenetic evidence of first-line asthma drugs in people of African ancestry is lacking and is further compounded by the lack of representative genetic association studies in the continent. In this review, we will discuss the paucity of data related to the pharmacogenetics of asthma drugs in people of African ancestry, mainly drawing from African American data. We will further discuss how this gap can be bridged to improve asthma health outcomes in Africa.
Selection of biophysically favorable antibody variants using a modified Flp-In CHO mammalian display platform
Authors: Huhtinen Olli , Salbo Rune , Lamminmäki Urpo , Prince Stuart
Published: May 2023

Mammalian display enables the selection of biophysically favorable antibodies from a large IgG antibody library displayed on the plasma membrane of mammalian cells. We constructed and validated a novel mammalian display platform utilizing the commercially available Flp-In CHO cell line as a starting point. We introduced a single copy of a landing pad for Bxb1 integrase-driven recombinase-mediated cassette exchange into the FRT site of the Flp-In CHO line to facilitate the efficient single-copy integration of an antibody display cassette into the genome of the cell line. We then proceeded to demonstrate the ability of our platform to select biophysically favorable antibodies from a library of 1 × 106 displayed antibodies designed to improve the biophysical properties of bococizumab via randomization of problematic hydrophobic surface residues of the antibody. Enrichment of bococizumab variants via fluorescence-activated cell sorting selections was followed by next generation sequencing and thorough characterization of biophysical properties of 10 bococizumab variants that subsequently allowed attribution of the mutations to the biophysical properties of the antibody variants. The mammalian displayed variants exhibited reduced aggregation propensity and polyreactivity, while critically retaining its target binding thereby demonstrating the utility of this valuable tool.
Development and evaluation of pH sensitive semi-interpenetrating networks: assessing the impact of itaconic acid and aloe vera on network swelling and cetirizine release
Authors: Ajaz Nyla , Bukhsh Munnaza , Kamal Yousaf , Rehman Fauzia , Irfan Muhammad , Khalid Syed Haroon , Asghar Sajid , Rizg Waleed Y. , Bukhary Sahar M. , Hosny Khaled M. , Alissa Mohammed , Safhi Awaji Y. , Sabei Fahad Y. , Khan Ikram Ullah
Published: May 2023

Hydrogels are crosslinked three-dimensional networks, and their properties can be easily tuned to target the various segments of the gastrointestinal tract (GIT). Cetirizine HCl (CTZ HCl) is an antihistaminic drug, which when given orally can upset the stomach. Moreover, this molecule has shown maximum absorption in the intestine. To address these issues, we developed a pH-responsive semi-interpenetrating polymer network (semi-IPN) for the delivery of CTZ HCl to the lower part of the GIT. Initially, 10 different formulations of itaconic acid-grafted-poly (acrylamide)/aloe vera [IA-g-poly (AAm)/aloe vera] semi-IPN were developed by varying the concentration of IA and aloe vera using the free radical polymerization technique. Based on swelling and sol-gel analysis, formulation F5 containing 0.3%w/w aloe vera and 6%w/w IA was chosen as the optimum formulation. The solid-state characterization of the optimized formulation (F5) revealed a successful incorporation of CTZ HCl in semi-IPN without any drug-destabilizing interaction. The in vitro drug release from F5 showed limited release in acidic media followed by a controlled release in the intestinal environment for over 72 h. Furthermore, during the in vivo evaluation, formulation F5 did not affect the hematological parameters, kidney, and liver functions. Clinical observations did not reveal any signs of illness in rabbits treated with hydrogels. Histopathological images of vital organs of treated animals showed normal cellular architecture. Thus, the results suggest a non-toxic nature and overall potential of the developed formulation as a targeted drug carrier.
Mussel-inspired HA@TA-CS/SA biomimetic 3D printed scaffolds with antibacterial activity for bone repair
Authors: Ji Cheng , Zhang Chengcheng , Xu Zeya , Chen Yan , Gan Yanming , Zhou Minghui , Li Lan , Duan Qinying , Huang Tingting , Lin Jinxin
Published: May 2023

Bacterial infection is a major challenge that could threaten the patient’s life in repairing bone defects with implant materials. Developing functional scaffolds with an intelligent antibacterial function that can be used for bone repair is very important. We constructed a drug delivery (HA@TA-CS/SA) scaffold with curcumin-loaded dendritic mesoporous organic silica nanoparticles (DMON@Cur) via 3D printing for antibacterial bone repair. Inspired by the adhesion mechanism of mussels, the HA@TA-CS/SA scaffold of hydroxyapatite (HA) and chitosan (CS) is bridged by tannic acid (TA), which in turn binds sodium alginate (SA) using electrostatic interactions. The results showed that the HA@TA-CS/SA composite scaffold had better mechanical properties compared with recent literature data, reaching 68.09 MPa. It displayed excellent degradation and mineralization capabilities with strong biocompatibility in vitro. Furthermore, the antibacterial test results indicated that the curcumin-loaded scaffold inhibited S.aureus and E.coli with 99.99% and 96.56% effectiveness, respectively. These findings show that 3D printed curcumin-loaded HA@TA-CS/SA scaffold has considerable promise for bone tissue engineering.
Blockchain based resource governance for decentralized web environments
Authors: Basile Davide , Di Ciccio Claudio , Goretti Valerio , Kirrane Sabrina
Published: May 2023

Decentralization initiatives such as Solid, Digi.me, and ActivityPub aim to give data owners more control over their data and to level the playing field by enabling small companies and individuals to gain access to data, thus stimulating innovation. However, these initiatives typically use access control mechanisms that cannot verify compliance with usage conditions after access has been granted to others. In this paper, we extend the state of the art by proposing a resource governance conceptual framework, entitled ReGov, that facilitates usage control in decentralized web environments. We subsequently demonstrate how our framework can be instantiated by combining blockchain and trusted execution environments. Through blockchain technologies, we record policies expressing the usage conditions associated with resources and monitor their compliance. Our instantiation employs trusted execution environments to enforce said policies, inside data consumers’ devices. We evaluate the framework instantiation through a detailed analysis of requirments derived from a data market motivating scenario, as well as an assessment of the security, privacy, and affordability aspects of our proposal.
New integrative tool for assessing vulnerable urban areas. Refurbishment model for energy self-sufficient and bio-healthy neighbourhoods. Madrid, Spain. HABITA-RES
Authors: Alonso Carmen , Martín-Consuegra Fernando , Oteiza Ignacio , De Frutos Fernando , González-Cruz Eduardo , Cuerdo-Vilches Teresa , Frutos Borja , Pérez Gloria , Fernández-Agüera Jessica , Dominguez-Amarillo Samuel
Published: May 2023

The research conducted under HABITA-RES explored the advisability of the integrative refurbishment of urban neighbourhoods on the outskirts of Madrid built between the end of the Civil War in 1939 and the enactment of the country’s first building code on the indoor environment in 1979. Characterised by highly inefficient buildings, many such neighbourhoods are listed as vulnerable urban areas. The study described hereunder analysed the feasibility of their conversion to energy self-sufficiency to improve residents’ environment, social circumstances and health. European directives and domestic legislation on energy production are introducing increasingly demanding requirements geared to achieving nearly zero energy buildings in 2020 and cities’ carbon neutrality by target year 2050. Possible approaches to achieve those ends were assessed under this study. The theoretical model used was validated with detailed information collected in situ on both social circumstances and energy efficiency. Designed to study improvement strategies for both individual and groups of buildings, the model prioritises passive improvements to lower demand. The findings will enable residents in such neighbourhoods to participate actively in improvement measures and access information on their costs and benefits.