bluuebunny/crossref_metadata_2025 huggingface dataset:
Applying continuous-time models to ecological momentary assessments: A practical introduction to the method and demonstration with clinical data
Authors: Abplanalp Samuel J. , Reavis Eric A. , Le Thanh P. , Green Michael F.
Published: March 2024

Ecological momentary assessment (EMA) is a frequently used approach among clinical researchers to collect naturalistic data in real time. EMA data can provide insights into the temporal dynamics of psychological processes. Traditional methods used to analyze EMA data, such as hierarchical linear modeling and multilevel vector auto-regression, paint an incomplete picture of the dynamics of psychological processes because they cannot capture how variables evolve outside predefined measurement occasions. Continuous-time models, an analytical approach that treats variables as dynamical systems that evolve continuously, overcome this limitation. Time advances smoothly in continuous-time models, contrasting with standard discrete-time models in which time progresses in finite jumps. This paper presents a practical introduction to continuous-time models for analyzing EMA data. To illustrate the method and its interpretation, we provide an empirical demonstration of a continuous-time model utilizing EMA data of real-time loneliness and mood states (happiness, sadness, and anxiety) from a clinical sample comprising Veterans with a history of mental illness. Psychological variables, such as feelings of loneliness or sadness, can often change many times throughout the day. However, standard ways of analyzing these variables do not accurately capture these changes and fluctuations. Here, we highlight the benefits of continuous-time models, a method that can capture subtle changes in such psychological variables over time.
BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly
Authors: Gan Shiming , Zhou Shumin , Ma Jinzhe , Xiong Mengneng , Xiong Wenjing , Fan Xu , Liu Kuan , Gui Yiqian , Chen Bei , Zhang Beibei , Wang Xiaoli , Wang Fengli , Li Zhean , Yan Wei , Ma Meisheng , Yuan Shuiqiao
Published: March 2024

Teratozoospermia is a significant cause of male infertility, but the pathogenic mechanism of acephalic spermatozoa syndrome (ASS), one of the most severe teratozoospermia, remains elusive. We previously reported Spermatogenesis Associated 6 (SPATA6) as the component of the sperm head-tail coupling apparatus (HTCA) required for normal assembly of the sperm head-tail conjunction, but the underlying molecular mechanism has not been explored. Here, we find that the co-chaperone protein BAG5, expressed in step 9-16 spermatids, is essential for sperm HTCA assembly. BAG5-deficient male mice show abnormal assembly of HTCA, leading to ASS and male infertility, phenocopying SPATA6-deficient mice. In vivo and in vitro experiments demonstrate that SPATA6, cargo transport-related myosin proteins (MYO5A and MYL6) and dynein proteins (DYNLT1, DCTN1, and DNAL1) are misfolded upon BAG5 depletion. Mechanistically, we find that BAG5 forms a complex with HSPA8 and promotes the folding of SPATA6 by enhancing HSPA8’s affinity for substrate proteins. Collectively, our findings reveal a novel protein-regulated network in sperm formation in which BAG5 governs the assembly of the HTCA by activating the protein-folding function of HSPA8.
Water-dispersible donor–acceptor–donor π-conjugated bolaamphiphiles enabling a humidity-responsive luminescence color change
Authors: Enjou Tomoya , Goto Shimpei , Liu Qiming , Ishiwari Fumitaka , Saeki Akinori , Uemtasu Taro , Ikemoto Yuka , Watanabe Sora , Matsuba Go , Ishibashi Kouichiro , Watanabe Go , Minakata Satoshi , Sagara Yoshimitsu , Takeda Youhei
Published: March 2024

Water-dispersible fluorescent bolaamphiphiles have been developed. Also, luminescence color change in response to humidity has been demonstrated with a composite material.
Substrate-controlled [4+1] and [3+2] annulations of ninhydrin-derived Morita–Baylis–Hillman carbonates to access polysubstituted furans and cyclopentenes
Authors: Wang Kai-Kai , Li Yan-Li , Li Ya-Fei , Yao Wei-Wei , Li Lan-Xin , He Xiao-Long , Chen Rongxiang
Published: March 2024

The substrate-enabled switching of the regioselectivity allows for efficient regiocontrol via [4+1] and [3+2] annulations of ninhydrin-derived MBH carbonates with α,β-unsaturated ketones to access highly substituted furans and cyclopentene.
Porous tremella-like NiMoP/CoP network electrodes as an efficient electrocatalyst
Authors: Wang Jianzhi , Yang Jie , Huang Fuhua , Li Yuru , Luo Yu , Xue Yanan , Cai Ning , Li Hui , Yu Faquan
Published: March 2024

Tremella-like NiMoP/CoP was synthesized on Ni foam via a hydrothermal and low-temperature phosphating method, exhibiting remarkable electrocatalytic activity with an ultralow overpotential of 38 mV (10 mA cm−2) and low Tafel slope of 83 mV dec−1.
Enhancing catalytic activity of Cr2O3 in CO2-assisted propane dehydrogenation with effective dopant engineering: a DFT-based microkinetic simulation
Authors: Jan Faheem , Zhi Shuaike , Sun XiaoYing , Li Bo
Published: March 2024

Using CO2 as a mild oxidizing agent in propane dehydrogenation (PDH) presents an attractive pathway for the generation of propene while maintaining high selectivity.
Reactivity of Ts and At oxides and oxyhydrides with a gold surface from periodic DFT calculations
Authors: Ryzhkov Anton , Pershina Valeria , Iliaš Miroslav , Shabaev Vladimir
Published: March 2024

DFT periodic calculations of adsorption properties of oxides and oxyhydrides of Ts and At on the surface of gold. Strong interaction of the considered species with the surface. Increasing reactivity of the Ts compounds with respect to the At ones.
Study of two-photon absorption and excited-state dynamics of coumarin derivatives: the effect of monomeric and dimeric structures
Authors: Jia Jidong , Li Jie , Zhang Tianwei , Lu YinLin , Song Yinglin
Published: March 2024

Intramolecular charge transfer (ICT) and π-electron delocalization are two key factors affecting the nonlinear optical absorption of organic molecules.
Benchmarking machine-readable vectors of chemical reactions on computed activation barriers
Authors: van Gerwen Puck , Briling Ksenia R. , Calvino Alonso Yannick , Franke Malte , Corminboeuf Clemence
Published: March 2024

We benchmark various methods for the prediction of computed activation barriers on three diverse datasets.
Identification of reaction intermediates in the decomposition of formic acid on Pd
Authors: Fingerhut Jan , Lecroart Loïc , Schwarzer Michael , Hörandl Stefan , Borodin Dmitriy , Kandratsenka Alexander , Kitsopoulos Theofanis N. , Auerbach Daniel J. , Wodtke Alec M.
Published: March 2024

We report an approach to identify intermediates for the formic acid decomposition reaction on Pd(111) and Pd(332) based on accurate measurements of isotopologue specific thermal reaction rates.
Cormorant-inspired macro-porous hydrogel thin film evaporators for boosting cost-effective solar water purification
Authors: Ma Guang-Lei , Qi Xi-Yan , Wei Qing-Cong , Shi Xiao-Fang , Chang Yi , Guo Yu-Ming , Hu Zhi-Guo , Ma Xiao-Ming
Published: March 2024

We develop a macro-porous hydrogel film strategy for solar water purification inspired by the structure of cormorant wings. The evaporation rate can reach 4.14 kg m−2 h−1 and the energy efficiency can reach 98% under one sun.
Development of a multi-isotopic (Pb, Fe, Cu) analytical protocol in gold matrices for ancient coin provenance studies
Authors: de Palaminy Louise , Poitrasson Franck , Baron Sandrine , Blet-Lemarquand Maryse , Perrière Loïc
Published: March 2024

Lead, copper and iron isotopes are precisely measured for the first time in gold matrices owing to an adapted purification protocol that allows the tracing of gold sources from archaeological and historical contexts.
Synthesis and photocatalytic property of Au–TiO2 nanocomposites with controlled morphologies in microfluidic chips
Authors: Ye Ziran , Lu Ping , Chen Yiben , Xu Zhixian , Huang Haixia , Zhi Mingjia , Chen Zi Ang , Yan Bo
Published: March 2024

We present an efficient approach for the consecutive synthesis of Au–TiO2 nanocomposites with controlled morphologies in a microfluidic chip.
Enhancing microplastic capture efficiencies with adhesive coatings on stainless-steel filters
Authors: Ramkumar Malavika , Ji Woojung , Thurber Henry E. , Clough Madeline E. , Chirdon Sarena , McNeil Anne J.
Published: March 2024

Poly(alkyl acrylate)-based adhesives are used as coatings for stainless-steel filters to enhance microplastic removal efficiencies via adsorption.
Silver-deposited titanium as a prophylactic ‘nano coat’ for peri-implantitis
Authors: Madiwal Vaibhav , Rajwade Jyutika
Published: March 2024

Dental implant failures caused by bacterial infections are a significant concern for dental implantologists.
Molybdenum phosphide nanoparticles encapsulated with biomolecule-derived N, P-codoped carbon nanosheets for the synergistic hydrogen evolution reaction
Authors: Peng Yixin , Liu Qianyi , Huang Baobing
Published: March 2024

A one-step pyrolysis strategy to synthesize novel MoP nanoparticles encapsulated with biomolecule-derived N, P-codoped carbon nanosheets for synergistic hydrogen evolution reaction.
Preparations of spherical nanoparticles of chiralCinchonaalkaloid-based bridged silsesquioxanes and their use in heterogeneous catalysis of enantioselective reactions
Authors: Tetour David , Novotná Marika , Tatýrek Jan , Máková Veronika , Stuchlík Martin , Hobbs Christopher , Řezanka Michal , Müllerová Monika , Setnička Vladimír , Dobšíková Kristýna , Hodačová Jana
Published: March 2024

Chiral spherical nanoparticulate organosilica materials containingCinchonaalkaloid derivatives were prepared and used as heterogeneous catalysts of enantioselective dihydroxylation of alkenes and chlorolactonization of 4-arylpent-4-enoic acids.
Ultralight aerogels via supramolecular polymerization of a new chiral perfluoropyridine-based sulfonimidamide organogelator
Authors: Proietti Giampiero , Axelsson Anton , Capezza Antonio J. , Todarwal Yogesh , Kuzmin Julius , Linares Mathieu , Norman Patrick , Szabó Zoltán , Lendel Christofer , Olsson Richard T. , Dinér Peter
Published: March 2024

Chiral perfluorinated sulfonimidamides act as low-molecular weight gelators at low critical gelation concentration (<1 mg mL−1) in unipolar organic solvents via supramolecular polymerization and form ultralight aerogels upon freeze-drying.
Synthesis and pharmacological activity of vinpocetine derivatives
Authors: Dong Zhang Chao , Shi Yang , Liu Li Juan , Feng Ting Ting , Zhou Ying , Pan Bo Wen
Published: March 2024

Vinpocetine and Vincamine were extensively employed in the treatment of ischemic stroke, serving as effective cerebrovascular vasodilators.
Latest technological advances and insights into capture and removal of hydrogen sulfide: a critical review
Authors: Aminuddin Muhammad Syahir , Bustam Mohamad Azmi , Johari Khairiraihanna
Published: March 2024

Hydrogen sulfide is an extremely toxic, poisonous and flammable gas often found in natural gas streams and crude oil reservoirs.
Challenges and opportunities for characterisation of high-temperature polymer electrolyte membrane fuel cells: a review
Authors: Zucconi Adam , Hack Jennifer , Stocker Richard , Suter Theo A. M. , Rettie Alexander J. E. , Brett Dan J. L.
Published: March 2024

High-temperature polymer electrolyte membrane fuel cells require advancements to capitalise on their advantages over conventional PEMFCs, the critical roles and opportunities for characterisation and durability testing are discussed in this review.
N, P co-doped graphene-supported monometallic nanoparticles for highly efficient hydrogen evolution by acid electrolysis of water
Authors: Wu Fengshun , Zeng Li , Pei An , Feng Yingliang , Zhu Lihua
Published: March 2024

Pt/rGNP exhibits much higher catalytic properties than other transition metal/rGNP catalysts for hydrogen evolution; its overpotential at 100 mA cm−2 in 0.5 M H2SO4 is only 10.6 mV, and its Tafel slope is 14.53 mV dec−1.
Suppression of the dark current in PbS quantum dot infrared photodetectors through the introduction of a CuInSeS interfacial layer
Authors: Chen Zuyan , Huang Tengzuo , Zhang Bo , Wu Chunyan , Zhang Xuanyu , Sun Tao , Xu Wei , Kang Kai , Xiang Chaoyu , Zhang Ting , Li Ruifeng
Published: March 2024

Lead sulfide (PbS) colloidal quantum dot (CQD) materials are extensively utilized in the fabrication of near-infrared detectors.
A novel in situ method for linear alkylbenzene sulfonate quantification in environmental samples using a digital image-based method
Authors: de Sousa Helayne S. , Arruda-Santos Roxanny , Zanardi-Lamardo Eliete , Suarez Willian T. , de Oliveira Josiane L. , Farias Renata A. , Bezerra dos Santos Vagner
Published: March 2024

Surfactants spilled in water resulting in the contamination of aquatic environments being in situ monitored using a smartphone.
High photocatalytic performance over ultrathin 2D TiO2 for CO2 reduction to alcohols
Authors: Yin Chenxu , Li Xue , Sun Shangcong , Wei Xiaoqian , Tong Qing , Tan Wei , Wang Xin , Peng Bo , Wan Haiqin , Dong Lin
Published: March 2024

We report a noble-metal-free photocatalyst, ultrathin TiO2 with atomic layer thickness, which is a potential catalyst for CO2 photoreduction.
Metal-free β,γ-C(sp3)–H difunctionalization of propanols: DMP-initiated asymmetric spirocyclopropanation
Authors: Li Zheyao , Zhang Huiwen , Zhao Lin , Ma Yueyue , Wu Qiufang , Ren Haosong , Lin Zhongren , Zheng Jun , Yu Xinhong
Published: March 2024

This work reports a one-pot asymmetric synthesis of spirocyclopropyl propionaldehydes/propanols via β,γ-bifunctionalization of propanols through the synergistic effect of a secondary amine catalyst and an oxidant.
Regulable high-contrast mechanofluorochromic enhancement behaviour based on substituent effects
Authors: Yang Guang , Zhao Wen-Xuan , Cao Jing-Yi , Xue Zeng-Min , Lin Hong-Tao , Chen Shu-Hai , Yamato Takehiko , Redshaw Carl , Wang Chuan-Zeng
Published: March 2024

Four mechanofluorochromic (MFC) luminogenic materials were prepared and found to exhibit outstanding mechanically-induced emission enhancement (MIEE) by virtue of substituent and position effects. Such materials can be used in OLED devices.
A DNA tetrahedron dimer for dual membrane protein logic recognition and interaction inhibition
Authors: Zhang Yuanmeng , Lin Muyang , Yao Jingkang , Xu Xiaowen
Published: March 2024

A DNA tetrahedron dimer is proposed for dual membrane protein logic recognition and interaction inhibition. The nanostructure can identify specific types of cells that express both proteins and particularly suppress the proliferation of target cells.
Introduction of new guest molecules into BEDT-TTF radical-cation salts with tris(oxalato)ferrate
Authors: Blundell Toby J. , Rusbridge Elizabeth K. , Pemberton Rebecca E. , Brannan Michael J. , Morritt Alexander L. , Ogar Joseph O. , Wallis John D. , Akutsu Hiroki , Nakazawa Yasuhiro , Imajo Shusaku , Martin Lee
Published: March 2024

We present the crystal structures of five new BEDT-TTF radical-cation salts with tris(oxalato)ferrate anions using solid or liquid additives toluene, phenol, benzaldehyde, 4-bromobenzaldehyde, and kojic acid.
Similarity scores of vibrational spectra reveal the atomistic structure of pentapeptides in multiple basins
Authors: Otaki Hiroki , Ishiuchi Shun-ichi , Fujii Masaaki , Sugita Yuji , Yagi Kiyoshi
Published: March 2024

A similarity score of vibrational spectra is proposed to reveal the structures of two conformers of a pentapeptide, acetyl-SIVSF-N-methylamide. One of the conformers is found to be 25 kJ mol−1 less stable than the most stable one.
Investigating the behaviour of NaCl brines and hydrocarbons in porous alumina using low-field NMR relaxation and diffusion methods
Authors: Mavridis Aristarchos , Sankey Mark , Chellappah Kuhan , D’Agostino Carmine
Published: March 2024

Low-field NMR methods are used to investigate brine wettability behaviour.
Correction: Porous oligomeric materials synthesised using a new, highly active precatalyst based on ruthenium(iii) and 2-phenylpyridine
Authors: Pobłocki Kacper , Jarzembska Katarzyna N. , Kamiński Radosław , Drzeżdżon Joanna , Deresz Krystyna A. , Schaniel Dominik , Gołąbiewska Anna , Gawdzik Barbara , Rybiński Przemysław , Jacewicz Dagmara
Published: March 2024

Correction for ‘Porous oligomeric materials synthesised using a new, highly active precatalyst based on ruthenium(iii) and 2-phenylpyridine’ by Kacper Pobłocki et al., Dalton Trans., 2024, 53, 4194–4203, https://doi.org/10.1039/D3DT04091G.
Tuning the peroxidase activity of artificial P450 peroxygenase by engineering redox-sensitive residues
Authors: Jiang Fengjie , Wang Zihan , Cong Zhiqi
Published: March 2024

Engineering redox-sensitive residues dramatically increases the peroxidase activity of P450BM3 monooxygenase, providing new insights and a strategy for regulating P450s' promiscuous functionality.
An efficient pyrrolysyl-tRNA synthetase for economical production of MeHis-containing enzymes
Authors: Hutton Amy E. , Foster Jake , Sanders James E. J. , Taylor Christopher J. , Hoffmann Stefan A. , Cai Yizhi , Lovelock Sarah L. , Green Anthony P.
Published: March 2024

A highly efficient aminoacyl tRNA synthetase (G1PylRSMIFAF) has been developed to produce MeHis-containing proteins. High protein titres can be achieved with low ncAA concentrations (0.1 mM) enabling more economical production of MeHis-containing enzymes.
Ultrathin redox active hydrogel electrolytes for high performance flexible supercapacitors
Authors: Xun Mengmeng , Shi Xiuting , Wang Haiping , Li Xiaoyan , Miao Wenxing , Wang Xiangbing , Sun Kanjun , Peng Hui , Ma Guofu , Xu Yuxi
Published: March 2024

An ultrathin poly(vinyl alcohol)/carboxymethyl chitosan with a redox ionic liquid (PVA/CMCS-[ViEtIm][Br]) gel electrolyte is prepared to improve the performance of supercapacitors.
Spin-degree manipulation for one-dimensional room-temperature ferromagnetism in a haldane system
Authors: Tan Pengfei , Zhu Chuanhui , Ni Xiaosheng , Wu Han-Qing , Zhao Shuang , Xia Tao , Yang Jinjin , Han Tao , Zhao Mei-Huan , Han Yifeng , Xia Yuanhua , Deng Zheng , Wu Muwei , Yao Dao-Xin , Li Man-Rong
Published: March 2024

Exotic ferromagnetic order up to ∼700 K has been introduced in the well-known S = 1 Haldane system nickelate, Y2BaNiO5, induced by locally mixed S = 1 and 1/2 states (d8-Ni2+ and d9-Ni+) and oxygen vacancies along the finite chain segments.
Overcoming microbial resuscitation using stable ultrafine gold nanosystems
Authors: Thakur Anindita , Maroju Pranay Amruth , Ganesan Ramakrishnan , Ray Dutta Jayati
Published: March 2024

The investigations with two categories of ultrafine gold nanosystems (UGNs) have shown sustained antibacterial activity elicited by the stable UGNs as the key for overcoming microbial resuscitation.
Insights into the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)-induced gelation of fully carboxylated collagen and the fabrication of hydrogels with enhanced mechanical properties
Authors: Zhang Juntao , Xu Haofei , Liu Yang , Sui Peishan , Deng Fen , Zheng Mingming , Liu Tianyi , Wei Benmei , Xu Chengzhi , Wang Haibo
Published: March 2024

EDC-induced gelation of succinylated collagen with a high concentration was realized, and its triple helix structure is crucial for this process. G′ of succinylated collagen hydrogel was improved to 310 Pa compared to 20 Pa of the collagen hydrogel.
High-efficiency ammonia synthesis via electrochemical nitrate reduction over Co3O4 nanoarrays by B doping
Authors: Deng Zhiqin , Liu Heng , Wang Huiyong , Ma Chaoqun , Du Juan , Zheng Baozhan
Published: March 2024

B acts as an effective dopant to boost the catalytic activity of Co3O4 for the nitrate reduction reaction towards NH3 synthesis. Such B-Co3O4/TM achieves a high faradaic efficiency of 94.7% and a large NH3 yield rate of 407.3 μmol h−1 cm−2.
Correction: The role of PMA in enhancing the surface acidity and catalytic activity of a bimetallic Cr–Mg-MOF and its applications for synthesis of coumarin and dihydropyrimidinone derivatives
Authors: Salama Reda S. , Hassan Shawky M. , Ahmed Awad I. , El-Yazeed W. S. Abo , Mannaa Mohammed A.
Published: March 2024

Correction for ‘The role of PMA in enhancing the surface acidity and catalytic activity of a bimetallic Cr–Mg-MOF and its applications for synthesis of coumarin and dihydropyrimidinone derivatives’ by Reda S. Salama et al., RSC Adv., 2020, 10, 21115–21128, https://doi.org/10.1039/D0RA03591B.
Expression of concern: An efficient one pot three-component nanocatalyzed synthesis of spiroheterocycles using TiO2 nanoparticles as a heterogeneous catalyst
Authors: Tailor Yogesh Kumar , Khandelwal Sarita , Kumari Yogita , Awasthi Kamlendra , Kumar Mahendra
Published: March 2024

Expression of concern for ‘An efficient one pot three-component nanocatalyzed synthesis of spiroheterocycles using TiO2 nanoparticles as a heterogeneous catalyst’ by Yogesh Kumar Tailor et al., RSC Adv., 2015, 5, 46415–46422, https://doi.org/10.1039/C5RA04863J.
Retraction: Interfacial adsorption study of nitrogen based inhibitors in silane nanocontainers as anticorrosive and self-healing material for steel in strong acid solution
Authors: M. S. Darris , Shibli S. M. A.
Published: March 2024

Retraction of ‘Interfacial adsorption study of nitrogen based inhibitors in silane nanocontainers as anticorrosive and self-healing material for steel in strong acid solution’ by Darris M. S. et al., J. Mater. Chem. A, 2023, Accepted Manuscript, https://doi.org/10.1039/D3TA02203J.
The effect of precursor concentrations on the structure and optoelectronic properties of quasi low-dimensional hybrid 2-methylpyridinium lead bromide crystalline phases
Authors: Shtarev D. S. , Chaplygina D. A. , Patrusheva O. V. , Chen C. , Shtareva A. V. , Stoumpos C. C. , Kevorkyants R. , Emeline A. V.
Published: March 2024

This work presents the synthesis and optoelectronic properties of the crystalline phases [Pb2Br5][C6NH8] and [PbBr3][C6NH8] of 2-methylpyridinium lead bromide.
Technological process and laws of change of energy consumption parameters of spinning enterprises
Authors: Khoshimov Fozildjon , Kаdirov Kamoliddin , Yusupalieva Khulkaroy , Kushev Alijon
Published: March 2024

Textile industrial enterprises are composed of three main sectors, which differ significantly from each other in terms of energy capacity, and include - spinning, weaving and finishing departments. In comparison to other departments, spinning technological processes consumes the most electricity. It is necessary to use modern energy-saving devices and to improve technological processes in accordance with the requirements of the times. Building an energy balance based on the analysis of the enterprise's technological processes, as well as forecasting electricity consumption, is one of the urgent issues. In this article, the issues of energy saving and efficiency improvement and forecasting in spinning departments are considered.
Dynamic Response of Bowstring-arch Highway Bridge Subjected to Above and Below Deck Close-range Large Explosion
Authors: Akram Shahbaz , Umair Mohammad , Alam Mehtab , Anas S.M.
Published: March 2024

Explosion incidents that are unforeseen can lead to the occurrence of extreme loads, resulting in the generation of remarkably high stress levels within the materials comprising various structures. This can cause significant damage to crucial elements and potentially trigger a disproportionate collapse or even initiate a progressive collapse. Bridge structures, which serve as vital lifelines for cosmopolitan areas and strategic bordering environments, hold immense economic and political significance. The failure of these structures can have severe consequences with far-reaching implications. The use of a steel bowstring-arch bridge is a practical choice for congested crossings and remote border areas where spans are short. However, the current design codes for bridges do not take into account high-strain loadings such as blasts or impacts, nor do they provide recommendations for preventing these occurrences during construction or throughout the lifespan of the bridge. Explosive incidents cause greater damage in terms of material damage and loss compared to earthquakes. There has been limited investigation into how steel-concrete bridges respond to explosions in the past. This study examines the numerical analysis of a bowstring-arch highway girder bridge made of steel and concrete. The bridge is supported at both ends and is subjected to close-range concentric explosions above and below the deck at the center and end of the bridge. To model the bridge and predict its behavior, the authors utilized the Abaqus software suite. For the analysis, a significant quantity of TNT weighing 1.63-tonne has been positioned at the midpoint of the bridge and is defined using the Eulerian-Lagrangian scheme. The transmission of the explosive shockwaves within the bridge material under the given loading circumstances is illustrated and elucidated. The behavior of the bridge is examined in relation to plastic deformations, primary stress, displacement, size of the crater, and overall energy of damage.
Status quo analysis of the Aidar-Arnasay Lake System
Authors: Erkabaev Furkat , Madrimov Rajabboy , Nurmatova Victoria
Published: March 2024

The Aidar-Arnasay lake system, situated within a natural depression in the southern expanse of the Kyzylkum desert, southwest of the Shardara reservoir, constitutes a unique hydrological entity. Comprising drainless lakes sustained by inflows from the collector-drainage network and the Shardara reservoir, this system has, over the span of 50 years, accumulated an astonishing 2.5 times more water than all 53 reservoirs combined in the province. However, recent studies conducted to assess the water quality in the Aidar-Arnasay lake system have revealed alarming concentrations of pollutants. A comprehensive analysis of the water samples has unveiled significant exceedances across nearly all measured indicators. Notably, the general mineralization of water stands out as a critical concern, surpassing the permissible norm by more than 25 times. This excessive mineralization poses a severe threat to the biological diversity within the system, impacting the overall ecological health of the region. The repercussions of these heightened pollutant levels extend beyond mere water quality concerns, adversely affecting the delicate balance of the ecosystem. Urgent intervention and remediation efforts are imperative to mitigate the ecological consequences and preserve the integrity of the Aidar-Arnasay lake system, ensuring its sustainability for future generations.
Role of faults and tectonic blocks in the Daugiztau gold deposit, Uzbekistan
Authors: Janibekov Bobir , Turapov Mirali , Tulyaganova Nargiza , Yunusova Oqibat , Ilyasova Dilfuza
Published: March 2024

This article delves into the comprehensive study of geodynamics concerning ore formation within the local area of gold ore mineralization in the central KyzylKum province. The primary focus lies in understanding the influential role of faults and tectonic blocks in the distribution of gold mineralization at the Daugyztau ore field. Geodynamics, as a significant factor in ore formation processes, is driven by external forces and prominently characterized by the dynamic activity of faults and blocks.The central KyzylKum province is renowned for its rich gold deposits, and exploring the underlying geodynamic processes is crucial for deciphering the mechanisms behind the formation and distribution of these valuable mineral resources. The study aims to shed light on the relationship between geodynamic phenomena and gold mineralization within the Daugyztau ore field.One of the key aspects under investigation is the role of faults, which are fractures or discontinuities in the Earth's crust, in controlling the migration and concentration of gold-bearing fluids. These faults act as pathways and conduits for the transportation of hydrothermal fluids, facilitating the deposition of gold and other associated minerals. By analyzing the spatial distribution and characteristics of faults in the area, researchers can gain insights into the geological processes responsible for gold mineralization.
Study on isolation methods of natural polysaccharides
Authors: Turatbekova Aidai , Yaxyaeva-Urunova Mavjuda , Usmanov Rasul , Jabbarova Ikbol , Shipilova Kamila , Yuldashev Boʻstonbek , Gulbaev Yakhshilik , Gulbaev Ulugbek
Published: March 2024

Polysaccharides are a significant and varied class of biomolecules that are vital to human health. They are complex carbohydrates made up of monosaccharide units. This scientific article provides a comprehensive review of the sources, extraction methods, and biomedical properties of polysaccharides. Understanding the intricacies of polysaccharides is crucial for harnessing their potential in various biomedical applications, ranging from drug delivery systems to immunomodulation. Polysaccharides are abundant in nature and can be found in a range of sources, such as marine organisms, bacteria, and plants. The unique structural diversity and inherent bioactivity of polysaccharides make them attractive candidates for biomedical research. This article aims to elucidate the diverse sources of polysaccharides, methods of extraction, and their biomedical properties.
Radiation exposure in routine mammography screening: a large observational cross-sectional study in Morocco
Authors: Tahiri Z. , Talbi M. , El Mansouri M. , Sekkat H. , Mkimel M. , Nhila O. , Essendoubi M. , Hiroual S.
Published: March 2024

This observational cross-sectional study aims to assess the exposure levels during mammography examinations in Morocco and provide an international comparative analysis. Patient data from 1100 mammographic examinations conducted in five units, comprising both digital radiography (DR) and computed radiography (CR) systems from various brands and models in the Rabat-Salé-Zemmour-Zaër region, were collected. The mean glandular dose (MGD) and technical parameters, including exposure factors and breast thickness, were analyzed. The collected data were compared with findings from international studies to provide valuable context. The overall median MGD was 1.34 ± 0.36 mGy for craniocaudal (CC) and 1.48 ± 0.38 mGy for mediolateral oblique (MLO) incidences. It’s essential to note that these values were calculated based on the median compressed breast thickness. The MGD varied among different units and anode/filter combinations. The Rh/Rh anode/filter combination was most commonly used, resulting in the lowest radiation dose. The study findings also highlighted the relationship between MGD and breast thickness, with higher doses observed for thicker breasts. This study provides valuable insights into radiation exposure during mammography breast cancer screening in Morocco. The results underscore the importance of future dose optimization strategies to ensure patient safety without compromising diagnostic image quality. Implementing optimized technical parameters, conducting regular quality assurance programs, and promoting education and awareness are essential in achieving dose reduction and minimizing radiation risks. Collaboration among healthcare professionals, regulatory bodies, and international organizations is crucial for sharing best practices and advancing radiation dose optimization in mammography.
Is There a Cumulative Effect for Congenital Heart Defects in Monochorionic Twins after Assisted Reproduction? – A Retrospective Analysis at a Tertiary Referral Center
Authors: Zdanowicz Jarmila A. , Yildrim Gülay , Fonseca Andreia , Hecher Kurt , Tavares de Sousa Manuela
Published: March 2024

The aim of our study was to compare maternal, chorionicity and neonatal complications in monochorionic (MC) twins between spontaneously conceived (SC) and assisted reproductive technologies (ART) pregnancies.

This was a retrospective cohort study between January 2010 to December 2019 at a tertiary referral University center. All consecutive pregnancies with MC twins that delivered at our University hospital were included. Maternal, chorionicity and neonatal complications were recorded and compared between SC and ART pregnancies.

393 MC pregnancies were included for final analysis, including 353 (89.8%) SC and 40 (10.2%) pregnancies conceived after ART. Hypothyroidism was the only maternal condition seen significantly more often in ART pregnancies (35.0% vs 12.5%, p = 0.001). There were no significant differences in chorionicity complications, such as twin-twin transfusion syndrome, selective fetal growth restriction and twin anemia-polycythemia sequence (40.0% in ART pregnancies vs 31.6% in SC pregnancies, p = 0.291). At least one congenital anomaly in one twin was seen significantly more often in ART pregnancies (18.8% vs 8.1%, p = 0.004), especially congenital heart defects (16.3% vs 6.2%, p = 0.005). There were no other significant differences in neonatal outcomes between both groups, however, there were non-significant trends in gestational age at delivery (34 weeks in ART pregnancies vs 35 weeks, p = 0.078) and birthweight (1951 g ± 747 in ART pregnancies vs 2143 g ± 579, p = 0.066).

This is the largest cohort study to date comparing maternal, chorionicity and neonatal complications between MC twin pregnancies after ART and after SC. Hypothyroidism was the only maternal condition occurring more frequently in pregnancies conceived after ART. There were no significant differences in chorionicity complications, in contrast to previously reported studies. While MC twins and ART pregnancies per se are known to be at risk for congenital heart defects, there seems to be a cumulative effect in MC pregnancies conceived after ART.
Relationship Between Urinary Iodine Concentration and the Prevalence
of Thyroid Nodules and Subclinical Hypothyroidism
Authors: Zhu Huachao , Chen Pu , Ding Xi , Zhao Yanru
Published: March 2024

The aim of the study was to investigate the iodine intake in the resident
population in Xi’an and analyze the relationship between iodine nutritional
status and the prevalence of subclinical hypothyroidism and thyroid nodules
(TNs). A total of 2507 people were enrolled in Xi’an. Venous serum thyroid
stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb) and thyroglobulin
antibody (TgAb), urinary iodine concentration (UIC), and thyroid ultrasonography
were collected. Patients with abnormal TSH were checked for free thyroxine (FT4)
and triiodothyronine (FT3). Adults in Xi’an had median UICs of 220.80 μg/L and
178.56 μg/l, respectively. A sum of 16.78% of people had subclinical
hypothyroidism. Both iodine excess and iodine deficit increased the frequency of
subclinical hypothyroidism. The lowest was around 15.09% in females with urine
iodine levels between 200 and 299 μg/l. With a rate of 10.69%, the lowest
prevalence range for males was 100–199 μg/l. In Xi’an, 11.37% of people have
TNs. In comparison to other UIC categories, TN occurrences were higher in
females (18.5%) and males (12%) when UIC were below 100 μg/l. In conclusion,
iodine intake was sufficient in the Xi’an area, while the adults’ UIC remains
slightly higher than the criteria. Iodine excess or deficiency can lead to an
increase in the prevalence of subclinical hypothyroidism. Patients with iodine
deficiency are more likely to develop TNs.
Dysregulation of miR-335-5p in People with Obesity and its Predictive
Value for Metabolic Syndrome
Authors: Lu Liting , He Yufeng
Published: March 2024

The epidemic of obesity and metabolic syndrome has become the most serious global
public health problem. The part played by microRNA (miRNA) in the onset and
progression of obesity and metabolic syndrome has been increasingly focused
upon. The goal of this study was to explore miR-335-5p as a potential predictive
biomarker or therapeutic target for obesity and metabolic syndrome. The
expression level of miR-335-5p was detected by qRT-PCR. The diagnostic value of
miR-335-5p was evaluated by ROC curve. The association between serum miR-335-5p
levels and various clinical parameters was assessed using the chi-square test.
Logistic regression analysis was used to evaluate the risk factors of metabolic
syndrome in obese population. The biological processes and molecular mechanisms
are studied through GO and KEGG enrichment analysis. The ROC curve analysis
revealed that miR-335-5p could serve as a predictive indicator for the
development of obesity accompanied by metabolic syndrome. Logistic regression
analysis revealed that BMI, TG, FBG, HOMA-IR, and miR-335-5p expression
represent independent risk factors of metabolic syndrome occurrence. Chi-square
test analysis revealed that patients with higher values of BMI, SBP, DBP, TG,
FBG, and HOMA-IR exhibited a more significantly increased expression of
miR-335-5p in their serum. In conclusion, miR-335-5p holds predictive and
diagnostic value for obesity and metabolic syndrome and has potential to serve
as a biomarker for these conditions.
Efficacy and safety of endoscopic ultrasound-guided hepaticogastrostomy: a meta-regression analysis
Authors: Binda Cecilia , Dajti Elton , Giuffrida Paolo , Trebbi Margherita , Coluccio Chiara , Cucchetti Alessandro , Fugazza Alessandro , Perini Barbara , Gibiino Giulia , Anderloni Andrea , Repici Alessandro , Fabbri Carlo
Published: March 2024

Background Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) is a valid option for EUS-guided biliary drainage that has been increasingly used in the last decade. The aims of this study were to provide a systematic review with meta-analysis and meta-regression of the features and outcomes of this procedure.

Methods The MEDLINE, Scopus, Web of Science, and Cochrane databases were searched for literature pertinent to EUS-HGS. Meta-analysis of the proportions and meta-regression of potential modifiers of the main outcome measures were applied. The main outcome was technical success; secondary outcomes were clinical success and procedure-related adverse events (AEs).

Results 33 studies, including 1644 patients, were included in the meta-analysis. Malignant biliary obstruction (MBO) was the underlying cause in almost all cases (99.6%); the main indications for EUS-HGS were duodenal/papillary invasion (34.8%), surgically altered anatomy (18.4%), and hilar stenosis (16.0%). The pooled technical success of EUS-HGS was 97.7% (95%CI 96.1%–99.0%; I
2 = 0%), the intention-to-treat clinical success rate was 88.1% (95%CI 84.7%–91.2%; I
2 = 33.9%), and procedure-related AEs occurred in 12.0% (95%CI 9.8%–14.5%; I
2 = 20.4%), with cholangitis/sepsis (2.8%) and bleeding (2.3%) the most frequent. The rate of procedure-related AEs was lower with the use of dedicated stents on univariable meta-regression analysis. Meta-regression showed that technical success and clinical success rates were modified by the centers’ experience (>4/year).

Conclusions EUS-HGS represents an effective and safe procedure for EUS-guided biliary drainage in patients with MBO. Future studies should address the impact of center experience, patient selection, and the use of dedicated stents to improve performance of this technique.
A simplified algorithm to evaluate the risk of submucosal invasive cancer in large (≥20 mm) nonpedunculated colonic polyps
Authors: O'Sullivan Timothy , Craciun Ana , Byth Karen , Gupta Sunil , Gauci Julia Louisa , Cronin Oliver , Whitfield Anthony , Abuarisha Muhammad , Williams Stephen John , Lee Eric Yong Tat , Burgess Nicholas Graeme , Bourke Michael J.
Published: March 2024

Background Recognition of submucosal invasive cancer (SMIC) in
large (≥20 mm) nonpedunculated colonic polyps (LNPCPs) informs selection of the optimal
resection strategy. LNPCP location, morphology, and size influence the risk of SMIC; however,
currently no meaningful application of this information has simplified the process to make it
accessible and broadly applicable. We developed a decision-making algorithm to simplify the
identification of LNPCP subtypes with increased risk of potential SMIC.

Methods Patients referred for LNPCP resection from September 2008
to November 2022 were enrolled. LNPCPs with SMIC were identified from endoscopic resection
specimens, lesion biopsies, or surgical outcomes. Decision tree analysis of lesion
characteristics identified in multivariable analysis was used to create a hierarchical
classification of SMIC prevalence.

Results 2451 LNPCPs were analyzed: 1289 (52.6%) were flat, 1043
(42.6%) nodular, and 118 (4.8%) depressed. SMIC was confirmed in 273 of the LNPCPs (11.1%). It
was associated with depressed and nodular vs. flat morphology (odds ratios [ORs] 35.7 [95%CI
22.6–56.5] and 3.5 [95%CI 2.6–4.9], respectively; P<0.001);
rectosigmoid vs. proximal location (OR 3.2 [95%CI 2.5–4.1]; P<0.001);
nongranular vs. granular appearance (OR 2.4 [95%CI 1.9–3.1]; P<0.001);
and size (OR 1.12 per 10-mm increase [95%CI 1.05–1.19]; P<0.001).
Decision tree analysis targeting SMIC identified eight terminal nodes: SMIC prevalence was 62%
in depressed LNPCPs, 19% in nodular rectosigmoid LNPCPs, and 20% in nodular proximal colon
nongranular LNPCPs.

Conclusions This decision-making algorithm simplifies
identification of LNPCPs with an increased risk of potential SMIC. When combined with surface
optical evaluation, it facilitates accurate lesion characterization and resection
choices.
Synthesis of Heteroaromatic-Fused Cyclic β-Amino Acids by Rhodium-Catalyzed Electrophilic Amination
Authors: Noda Hidetoshi , Shibasaki Masakatsu , Manoharan Ramasamy , Asada Yasuko
Published: March 2024

A series of cyclic β-amino acids fused with heteroaromatic moieties was prepared by Rh-catalyzed electrophilic amination. The transformation involves a rhodium alkyl nitrene generated from substituted isoxazolidin-5-ones upon the N–O bond cleavage. These products contain an underexplored class of cyclic structures that may have specific applications in various chemistry disciplines.
Lanthanoids in Hydroarylaminations: Yb(III)- and Tb(III)-Catalyzed Addition of Arylamines to Activated Olefins
Authors: Kunjanpillai Rajesh , Rajesh Rajagopal , Sandhya Olencheri Karimpanakkal , Narayanan Sunilkumar Puthenpurackal
Published: March 2024

Michael-type hydroaminations of acrylonitrile, phenyl vinyl sulfone, and dimethyl maleate were realized using arylamines catalyzed independently by Yb(OTf)3 and Tb(OTf)3 to give the desired β-aminonitriles, β-amino sulfones, and dimethyl aspartates, respectively, in moderate to excellent yields. The reactions were carried out in toluene for Yb(OTf)3 and in t-BuOMe for Tb(OTf)3, all reactions were performed at 100 °C.
Stereoselective Synthesis of Acylethenyl Tetrahydropyridino- and Deazepanopyrrolo[1,2-c]imidazolidines via Annulation of Cyclic Imines with Acylethynylpyrroles
Authors: Trofimov Boris A. , Oparina Ludmila A. , Belyaeva Kseniya V. , Kolyvanov Nikita A. , Ushakov Igor A. , Sagitova Elena F.
Published: March 2024

A new and efficient strategy for the stereoselective synthesis of tetrahydropyridino- and deazepanopyrrolo[1,2-c]imidazolidines has been developed. Annulation of acylethynylpyrroles with six- and seven-membered cyclic imines (MeCN/THF, 20–25 °C, 24–72 h) leads to tetrahydropyrrolo[1′,2′:3,4]imidazo[1,2-a]pyridines and hexahydropyrrolo[1′,2′:3,4]imidazo[1,2-a]azepines with (E)-acylethenyl moiety in 28–96% yields.
Eye Diseases: When the Solution Comes from Plant Alkaloids
Authors: Lorrai Riccardo , Cavaterra Dario , Giammaria Sara , Sbardella Diego , Tundo Grazia Raffaella , Boccaccini Alessandra
Published: March 2024

Plants are an incredible source of metabolites showing a wide range of biological activities. Among these, there are the alkaloids, which have been exploited for medical purposes since ancient times. Nowadays, many plant-derived alkaloids are the main components of drugs used as therapy for different human diseases. This review deals with providing an overview of the alkaloids used to treat eye diseases, describing the historical outline, the plants from which they are extracted, and the clinical and molecular data supporting their therapeutic activity. Among the different alkaloids that have found application in medicine so far, atropine and pilocarpine are the most characterized ones. Conversely, caffeine and berberine have been proposed for the treatment of different eye disorders, but further studies are still necessary to fully understand their clinical value. Lastly, the alkaloid used for managing hypertension, reserpine, has been recently identified as a potential
drug for ameliorating retinal disorders. Other important aspects discussed in this review are different solutions for alkaloid production. Given that the industrial production of many of the plant-derived alkaloids still relies on extraction from plants, and the chemical synthesis can be highly expensive and poorly efficient, alternative methods need to be found. Biotechnologies offer a multitude of possibilities to overcome these issues, spanning from genetic engineering to synthetic biology for microorganisms and bioreactors for plant cell cultures. However, further efforts are needed to completely satisfy the pharmaceutical demand.
Outpatient Prescription Opioid Use following Discharge after Deep Inferior Epigastric Perforator Breast Reconstruction with and without an Educational Intervention
Authors: Marquez Jessica L. , Chow Josh , Moss Whitney , Luo Jessica , Eddington Devin , Agarwal Jayant P. , Kwok Alvin C.
Published: March 2024

Background There is limited evidence for appropriate postoperative opioid prescribing in autologous breast reconstruction. We sought to describe postoperative outpatient prescription opioid use following discharge after deep inferior epigastric perforator (DIEP) breast reconstruction with and without an educational video.

Methods Patients undergoing DIEP reconstruction were given a 28-day postoperative pain and medication logbook from August 2022 to June 2023. Our practice implemented an educational video upon discharge on proper opioid consumption. Descriptive statistics on patient characteristics, intraoperative and postoperative opioid consumption, and outpatient prescription opioid use after discharge were compared between the two cohorts.

Results A total of 53 logbooks were completed with 20 patients in the no video cohort and 33 in the video cohort. On average, the days to cessation of opiates was longer in the no video cohort (8.2 vs. 5.1 days, p = 0.003). The average number of oxycodone 5 mg equivalents consumed following discharge was 13.8 in the no video cohort and 7.8 in the video cohort, which was statistically significant (p = 0.01). Overall, the percentage of opioids prescribed that were consumed in the video cohort was 28.3% versus 67.1% in the no video cohort.

Conclusion For patients discharging home after DIEP reconstruction, we recommend a prescription for 12 oxycodone 5 mg tablets. With the use of an educational video regarding proper opioid consumption, we were able to reduce the total outpatient opioid use to 5 oxycodone 5 mg tablets following hospital discharge.
The Difunctionalization of Alkenes Completed by DMTSM and CF3SO2Na without Metal Catalysts
Authors: Yan Rulong , Shen Siwei , Gao Jinzhao , Luo Xiaofeng , Wang Tianqiang , Liu Peihua
Published: March 2024

The electrophilic thiolation of alkenes initiated by DMTSM and the addition of CF3SO2Na in one pot has been developed. This reaction also can be extended to ArSO2Na. This protocol features a good substrate scope, simple procedures, and mild reaction conditions and affords the desired products in moderate yields without metal catalysts.
Microsurgical reconstruction of the breast: ‘The versatile lower abdomen’
Authors: Ramakrishnan Venkat V
Published: March 2024

Since the first reported use of lower abdominal tissue from the lower abdominal skin and fat by Hans Holmstrom in 1979, there have been over 300 publications on this subject. The refinements have been aimed at Ule limitation of donor mOibidity and to allow a predictable success of the transfer. This article analyses the landmarks and highlights the key developments in this area. The more recent development in this area - the Deep Inferior Epigastric Perforator flap is discussed.
Congenital anterior urethrocutaneous fistula revisited
Authors: Agarwal Pawan
Published: March 2024

Congenital anterior urethrocutaneous fistulas are rare. A case of this unusual anomaly is presented with review of literature, discussion of the possible etiology and management strategy.