bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 6 from Deletion or Epigenetic Silencing of AJAP1 on 1p36 in Glioblastoma
Authors: Lin Ningjing , Di Chunhui , Bortoff Kathy , Fu Jinrong , Truszkowski Peter , Killela Patrick , Duncan Chris , McLendon Roger , Bigner Darell , Gregory Simon , Adamson David Cory
Published: April 2023

PDF file - 74K
Figure S6 from Mesothelin Enhances Tumor Vascularity in Newly Forming Pancreatic Peritoneal Metastases
Authors: Avula Leela Rani , Rudloff Michael , El-Behaedi Salma , Arons Danielle , Albalawy Rakan , Chen Xiongfong , Zhang Xianyu , Alewine Christine
Published: April 2023

Identifying a novel mediator for MSLN activity using qPCR.
Supplementary Figure 3 from Deletion or Epigenetic Silencing of AJAP1 on 1p36 in Glioblastoma
Authors: Lin Ningjing , Di Chunhui , Bortoff Kathy , Fu Jinrong , Truszkowski Peter , Killela Patrick , Duncan Chris , McLendon Roger , Bigner Darell , Gregory Simon , Adamson David Cory
Published: April 2023

PDF file - 60K
Figure S5 from Mesothelin Enhances Tumor Vascularity in Newly Forming Pancreatic Peritoneal Metastases
Authors: Avula Leela Rani , Rudloff Michael , El-Behaedi Salma , Arons Danielle , Albalawy Rakan , Chen Xiongfong , Zhang Xianyu , Alewine Christine
Published: April 2023

Examination of involvement of NF-κB pathway in MSLN IP pro-tumorigenicity.
Figure S4 from Mesothelin Enhances Tumor Vascularity in Newly Forming Pancreatic Peritoneal Metastases
Authors: Avula Leela Rani , Rudloff Michael , El-Behaedi Salma , Arons Danielle , Albalawy Rakan , Chen Xiongfong , Zhang Xianyu , Alewine Christine
Published: April 2023

Examination of protein signaling pathways.
Supplementary Figure 1 from Deletion or Epigenetic Silencing of AJAP1 on 1p36 in Glioblastoma
Authors: Lin Ningjing , Di Chunhui , Bortoff Kathy , Fu Jinrong , Truszkowski Peter , Killela Patrick , Duncan Chris , McLendon Roger , Bigner Darell , Gregory Simon , Adamson David Cory
Published: April 2023

PDF file - 28K
Figure S1 from Mesothelin Enhances Tumor Vascularity in Newly Forming Pancreatic Peritoneal Metastases
Authors: Avula Leela Rani , Rudloff Michael , El-Behaedi Salma , Arons Danielle , Albalawy Rakan , Chen Xiongfong , Zhang Xianyu , Alewine Christine
Published: April 2023

MSLN sequence showing positioning of the Exon 3 gRNA site.
Supplementary Figure 1 from Fibroblast Growth Factor Receptor Mediates Fibroblast-Dependent Growth in EMMPRIN-Depleted Head and Neck Cancer Tumor Cells
Authors: Liu Zhiyong , Hartman Yolanda E. , Warram Jason M. , Knowles Joseph A. , Sweeny Larissa , Zhou Tong , Rosenthal Eben L.
Published: April 2023

Supplementary Figure 1 from Fibroblast Growth Factor Receptor Mediates Fibroblast-Dependent Growth in EMMPRIN-Depleted Head and Neck Cancer Tumor Cells
Supplementary Data from Dominant-Negative Features of Mutant TP53 in Germline Carriers Have Limited Impact on Cancer Outcomes
Authors: Monti Paola , Perfumo Chiara , Bisio Alessandra , Ciribilli Yari , Menichini Paola , Russo Debora , Umbach David M. , Resnick Michael A. , Inga Alberto , Fronza Gilberto
Published: April 2023

Supplementary Tables S1-S5.
Supplementary File S1 from Interactions with Fibroblasts Are Distinct in Basal-Like and Luminal Breast Cancers
Authors: Camp J. Terese , Elloumi Fathi , Roman-Perez Erick , Rein Jessica , Stewart Delisha A. , Harrell J. Chuck , Perou Charles M. , Troester Melissa A.
Published: April 2023

Supplementary File S1 from Interactions with Fibroblasts Are Distinct in Basal-Like and Luminal Breast Cancers
Supplementary Data from Small Interfering RNA–Directed Knockdown of Uracil DNA Glycosylase Induces Apoptosis and Sensitizes Human Prostate Cancer Cells to Genotoxic Stress
Authors: Pulukuri Sai Murali Krishna , Knost James A. , Estes Norman , Rao Jasti S.
Published: April 2023

Supplementary Data from Small Interfering RNA–Directed Knockdown of Uracil DNA Glycosylase Induces Apoptosis and Sensitizes Human Prostate Cancer Cells to Genotoxic Stress
Supplementary Data from Long-term Stability of Demethylation after Transient Exposure to 5-Aza-2′-Deoxycytidine Correlates with Sustained RNA Polymerase II Occupancy
Authors: Kagey Jacob D. , Kapoor-Vazirani Priya , McCabe Michael T. , Powell Doris R. , Vertino Paula M.
Published: April 2023

Supplementary Figures S1-S3 and Supplementary Table S1.
Supplementary Data from Loss-of-Function Fibroblast Growth Factor Receptor-2 Mutations in Melanoma
Authors: Gartside Michael G. , Chen Huaibin , Ibrahimi Omar A. , Byron Sara A. , Curtis Amy V. , Wellens Candice L. , Bengston Ana , Yudt Laura M. , Eliseenkova Anna V. , Ma Jinghong , Curtin John A. , Hyder Pilar , Harper Ursula L. , Riedesel Erica , Mann Graham J. , Trent Jeffrey M. , Bastian Boris C. , Meltzer Paul S. , Mohammadi Moosa , Pollock Pamela M.
Published: April 2023

Supplementary Data from Loss-of-Function Fibroblast Growth Factor Receptor-2 Mutations in Melanoma
Supplementary Data from Wilms' Tumor 1 Suppressor Gene Mediates Antiestrogen Resistance via Down-Regulation of Estrogen Receptor-α Expression in Breast Cancer Cells
Authors: Han Youqi , Yang Lin , Suarez-Saiz Fernando , San-Marina Serban , Cui Jie , Minden Mark D.
Published: April 2023

Supplementary Data from Wilms' Tumor 1 Suppressor Gene Mediates Antiestrogen Resistance via Down-Regulation of Estrogen Receptor-α Expression in Breast Cancer Cells
Supplementary Data from Protein Sialylation by Sialyltransferase Involves Radiation Resistance
Authors: Lee Minyoung , Lee Hae-June , Bae Sangwoo , Lee Yun-Sil
Published: April 2023

Supplementary Data from Protein Sialylation by Sialyltransferase Involves Radiation Resistance
Supplementary Figure 1 from Regulation of Cell Cycle Genes and Induction of Senescence by Overexpression of OTX2 in Medulloblastoma Cell Lines
Authors: Bunt Jens , de Haas Talitha G. , Hasselt Nancy E. , Zwijnenburg Danny A. , Koster Jan , Versteeg Rogier , Kool Marcel
Published: April 2023

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Supplementary Figures S1-S4 from A Novel Role of Dipeptidyl Peptidase 9 in Epidermal Growth Factor Signaling
Authors: Yao Tsun-Wen , Kim Woo-Shin , Yu Denise MT. , Sharbeen George , McCaughan Geoffrey W. , Choi Kang-Yell , Xia Pu , Gorrell Mark D.
Published: April 2023

Supplementary Figures S1-S4 from A Novel Role of Dipeptidyl Peptidase 9 in Epidermal Growth Factor Signaling
Supplementary Figures S1-S2 from Expression Regulation of the Metastasis-Promoting Protein InsP3-Kinase-A in Tumor Cells
Authors: Chang Lydia , Schwarzenbach Heidi , Meyer-Staeckling Sönke , Brandt Burkard , Mayr Georg W. , Weitzel Joachim M. , Windhorst Sabine
Published: April 2023

Supplementary Figures S1-S2.
Supplementary Data from Wild-Type BRCA1, but not Mutated BRCA1, Regulates the Expression of the Nuclear Form of β-Catenin
Authors: Li Huchun , Sekine Masayuki , Tung Nadine , Avraham Hava Karsenty
Published: April 2023

Supplementary Data from Wild-Type BRCA1, but not Mutated BRCA1, Regulates the Expression of the Nuclear Form of β-Catenin
Supplementary Figure 2 from Osteopontin Stimulates Preneoplastic Cellular Proliferation Through Activation of the MAPK Pathway
Authors: Luo Xianmin , Ruhland Megan K. , Pazolli Ermira , Lind Anne C. , Stewart Sheila A.
Published: April 2023

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Supplementary Figure S1 from Role of the Protein Tyrosine Kinase Syk in Regulating Cell-Cell Adhesion and Motility in Breast Cancer Cells
Authors: Zhang Xiaoying , Shrikhande Ulka , Alicie Bethany M. , Zhou Qing , Geahlen Robert L.
Published: April 2023

Supplementary Figure S1 from Role of the Protein Tyrosine Kinase Syk in Regulating Cell-Cell Adhesion and Motility in Breast Cancer Cells
Supplementary Data from Acquired Resistance to Combination Treatment with Temozolomide and ABT-888 Is Mediated by Both Base Excision Repair and Homologous Recombination DNA Repair Pathways
Authors: Liu Xuesong , Han Edward K. , Anderson Mark , Shi Yan , Semizarov Dimitri , Wang Gang , McGonigal Thomas , Roberts Lisa , Lasko Loren , Palma Joann , Zhu Gui-dong , Penning Thomas , Rosenberg Saul , Giranda Vincent L. , Luo Yan , Leverson Joel , Johnson Eric F. , Shoemaker Alexander R.
Published: April 2023

Supplementary Data from Acquired Resistance to Combination Treatment with Temozolomide and ABT-888 Is Mediated by Both Base Excision Repair and Homologous Recombination DNA Repair Pathways
Supplementary Table 1 from Dual Screen for Efficacy and Toxicity Identifies HDAC Inhibitor with Distinctive Activity Spectrum for BAP1-Mutant Uveal Melanoma
Authors: Kuznetsoff Jeffim N. , Owens Dawn A. , Lopez Andy , Rodriguez Daniel A. , Chee Nancy T. , Kurtenbach Stefan , Bilbao Daniel , Roberts Evan R. , Volmar Claude-Henry , Wahlestedt Claes , Brothers Shaun P. , Harbour J. William
Published: April 2023

Table S1. Results of differential expression analysis
Supplementary Fig 2 from Heme Sequestration Effectively Suppresses the Development and Progression of Both Lung Adenocarcinoma and Squamous Cell Carcinoma
Authors: Dey Sanchareeka , Ashrafi Adnin , Vidal Chantal , Jain Nivesh , Kalainayakan Sarada Preeta , Ghosh Poorva , Alemi Parinaz Sadat , Salamat Narges , Konduri Purna Chaitanya , Kim Jung-whan , Zhang Li
Published: April 2023

Supplementary Figure 2. The levels of representative OXPHOS complex subunits in ADC and SCC tumors developed in KLLuc mice. A, Representative IHC images of lung tissue sections showing levels of COX5B, along with ADC marker NKX2-1 and SCC marker Î"Np63, from KLLuc mice at 10 weeks after the initiation of tumorigenesis via viral infection. B, Representative IHC images of lung tissue sections showing levels of COX7B, along with ADC marker NKX2-1 and SCC marker Î"Np63, from KLLuc mice at 10 weeks after the initiation of tumorigenesis via viral infection. C, Representative IHC images of lung tissue sections showing levels of CYCS, along with ADC marker NKX2-1 and SCC marker Î"Np63, from KLLuc mice at 10 weeks after the initiation of tumorigenesis via viral infection. Shown are montage and 10X images of lung tissue sections stained with DAPI (row 1), antibodies to NKX2-1 or Î"Np63 (row 2), antibodies to the indicated protein (row 3), and merged images of NKX2-1 or Î"Np63 with the indicated protein (row 4). The light green lines in DAPI montage images outline the tumors in the lung. The white arrows denote the regions shown in 10X images. Scale bar, montage, 1mm; 10X, 100Âµm. D, Graph showing quantified levels of COX5B in ADC and SCC tumors correlating with A. E, Graph showing quantified levels of COX7B in ADC and SCC tumors correlating with B. F, Graph showing quantified levels of CYCS in ADC and SCC tumors correlating with C. Protein levels were quantified, and data are plotted as mean {plus minus} SEM.
Video 1 from Tumor-Resident Stromal Cells Promote Breast Cancer Invasion through Regulation of the Basal Phenotype
Authors: Hanley Christopher J. , Henriet Elodie , Sirka Orit Katarina , Thomas Gareth J. , Ewald Andrew J.
Published: April 2023

Co-culture of tumor organoids with stromal cells increases tumor cells invasion in collagen I.
Supplemental Figures 1-6 from AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer
Authors: Beck Anna C. , Cho Edward , White Jeffrey R. , Paemka Lily , Li Tiandao , Gu Vivian W. , Thompson Dakota T. , Koch Kelsey E. , Franke Christopher , Gosse Matthew , Wu Vincent T. , Landers Shannon R. , Pamatmat Anthony J. , Kulak Mikhail V. , Weigel Ronald J.
Published: April 2023

S1. Confirmation of AP-2α expression. S2. Comparative growth of parental and KO clones. S3. FACS Analysis of Apoptotic Cells with TFAP2AKO. S4. AP-2α binding site. S5. Colon cancer tissue microarray analysis (TMA). S6. TFAP2Aand TGM2 Expression in Response to BKM120.
Table S3 from Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1
Authors: Calvo Jennifer A. , Fritchman Briana , Hernandez Desiree , Persky Nicole S. , Johannessen Cory M. , Piccioni Federica , Kelch Brian A. , Cantor Sharon B.
Published: April 2023

Predicted Functional consequence of LOF mutations based on homology model
Figure S5 from Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1
Authors: Calvo Jennifer A. , Fritchman Briana , Hernandez Desiree , Persky Nicole S. , Johannessen Cory M. , Piccioni Federica , Kelch Brian A. , Cantor Sharon B.
Published: April 2023

Sensitivity data from validated FANCJ LOF mutations
Table S2 from A Novel miR-146a-POU3F2/SMARCA5 Pathway Regulates Stemness and Therapeutic Response in Glioblastoma
Authors: Cui Tiantian , Bell Erica H. , McElroy Joseph , Liu Kevin , Sebastian Ebin , Johnson Benjamin , Gulati Pooja Manchanda , Becker Aline Paixao , Gray Ashley , Geurts Marjolein , Subedi Depika , Yang Linlin , Fleming Jessica L. , Meng Wei , Barnholtz-Sloan Jill S. , Venere Monica , Wang Qi-En , Robe Pierre A. , Haque S. Jaharul , Chakravarti Arnab
Published: April 2023

Table S2. Antibodies used in the study
Table S4 from IQGAP3, a YAP Target, Is Required for Proper Cell-Cycle Progression and Genome Stability
Authors: Leone Marina , Cazorla-Vázquez Salvador , Ferrazzi Fulvia , Wiederstein Janica L. , Gründl Marco , Weinstock Grit , Vergarajauregui Silvia , Eckstein Markus , Krüger Marcus , Gaubatz Stefan , Engel Felix B.
Published: April 2023

Interactome of IQGAP3
Figure S9 from A Novel miR-146a-POU3F2/SMARCA5 Pathway Regulates Stemness and Therapeutic Response in Glioblastoma
Authors: Cui Tiantian , Bell Erica H. , McElroy Joseph , Liu Kevin , Sebastian Ebin , Johnson Benjamin , Gulati Pooja Manchanda , Becker Aline Paixao , Gray Ashley , Geurts Marjolein , Subedi Depika , Yang Linlin , Fleming Jessica L. , Meng Wei , Barnholtz-Sloan Jill S. , Venere Monica , Wang Qi-En , Robe Pierre A. , Haque S. Jaharul , Chakravarti Arnab
Published: April 2023

Fig. S9 POU3F2 and SMARCA5 are two target candidates of miR-146a
Figure S5 from A Novel miR-146a-POU3F2/SMARCA5 Pathway Regulates Stemness and Therapeutic Response in Glioblastoma
Authors: Cui Tiantian , Bell Erica H. , McElroy Joseph , Liu Kevin , Sebastian Ebin , Johnson Benjamin , Gulati Pooja Manchanda , Becker Aline Paixao , Gray Ashley , Geurts Marjolein , Subedi Depika , Yang Linlin , Fleming Jessica L. , Meng Wei , Barnholtz-Sloan Jill S. , Venere Monica , Wang Qi-En , Robe Pierre A. , Haque S. Jaharul , Chakravarti Arnab
Published: April 2023

Fig. S5 Dox-inducible stable GBM cell model
Supplementary Table 2 from Heterogeneity and Cancer-Related Features in Lymphangioleiomyomatosis Cells and Tissue
Authors: Espín Roderic , Baiges Alexandra , Blommaert Eline , Herranz Carmen , Roman Antonio , Saez Berta , Ancochea Julio , Valenzuela Claudia , Ussetti Piedad , Laporta Rosalía , Rodríguez-Portal José A. , van Moorsel Coline H.M. , van der Vis Joanne J. , Quanjel Marian J.R. , Villar-Piqué Anna , Diaz-Lucena Daniela , Llorens Franc , Casanova Álvaro , Molina-Molina María , Plass Mireya , Mateo Francesca , Moss Joel , Pujana Miquel Angel
Published: April 2023

Table S2. A, Differentially expressed LAMp genes between non-LAM and LAM cells (FDR < 5%; Guo dataset). B, Differential gene expression between LAM cells with low and high LAMcore values (all genes considered). C, Curated gene sets positively correlated (FDR < 5%) with LAMcore in LAM cells. D, Curated gene sets negatively correlated (FDR < 5%) with LAMcore in LAM cells. E, Curated gene sets positively correlated (FDR < 5%) with LAMp in LAM cells. F, Curated gene sets negatively correlated (FDR < 5%) with LAMp in LAM cells. G, Overexpressed genes (n = 50) in depicted six cancer cell lines and LAM cells, relative to all other cancer cell lines analyzed. H, Overrepresented GO terms and KEGG pathways in the 50 genes commonly overexpressed in the six cancer cell lines and LAM cells. I, Overrepresented transcription factor binding sites in LAMp and LAMcore signatures. J, Overrepresented GO terms and KEGG pathways (FDR < 5%) in 10% of the most variably expressed genes among bulk LAM lung samples. K, Inferred immune cell contents in bulk LAM lung nodules (n = 14; GEO GSE12027) using CIBERSORTx.
Figure S2 from Epstein-Barr Virus Induces Lymphangiogenesis and Lympth Node Metastasis via Upregulation of VEGF-C in Nasopharyngeal Carcinoma
Authors: Li Deng-Ke , Chen Xing-Rui , Wang Li-Na , Wang Jia-Hong , Wen Yue-Ting , Zhou Zi-Ying , Li Ji-Ke , Liu Jing-Xian , Cai Lin-Bo , Zhong Shui-Sheng , Lyu Xiao-Ming , Damola Faleti Oluwasijibomi , Li Min-Ying , Zhang Jing-Jing , Zeng Yu-Mei , Wang Qian-Li , Zhang Qian-Bing , Lyu Hao , Fu Xiao-Yan , Wang Wei , Li Xin , Huang Zhong-Xi , Yao Kai-Tai
Published: April 2023

The expression pattern of VEGF-D in EBV-negative and EBV-positive cell lines, cellular supernatant, and specimens
Supplementary Figure 3 from Radiomics Biomarkers Correlate with CD8 Expression and Predict Immune Signatures in Melanoma Patients
Authors: Aoude Lauren G. , Wong Bernadette Z.Y. , Bonazzi Vanessa F. , Brosda Sandra , Walters Shaun B. , Koufariotis Lambros T. , Naeini Marjan M. , Pearson John V. , Oey Harald , Patel Kalpana , Bradford Julia J. , Bloxham Conor J. , Atkinson Victoria , Law Phillip , Strutton Geoffrey , Bayley Gerard , Yang Samuel , Smithers B. Mark , Waddell Nicola , Miles Kenneth , Barbour Andrew P.
Published: April 2023

Multiplex immunofluorescence staining quantification by Visiopharm Image Analytical System. DAPI nuclei were segmented defining the areas. Then each marker was quantified within this DAPI area. MPP4 low (MelR062) and MPP4 high (MelR166) phenotypes are represented.
Supplementary Figure 1 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase
Authors: Ginzel Joshua D. , Acharya Chaitanya R. , Lubkov Veronica , Mori Hidetoshi , Boone Peter G. , Rochelle Lauren K. , Roberts Wendy L. , Everitt Jeffrey I. , Hartman Zachary C. , Crosby Erika J. , Barak Lawrence S. , Caron Marc G. , Chen Jane Q. , Hubbard Neil E. , Cardiff Robert D. , Borowsky Alexander D. , Lyerly H. Kim , Snyder Joshua C.
Published: April 2023

HER2BOW transgene design
Table S3 from Thyroid Hormone Receptor Beta Induces a Tumor-Suppressive Program in Anaplastic Thyroid Cancer
Authors: Bolf Eric L. , Gillis Noelle E. , Davidson Cole D. , Rodriguez Princess D. , Cozzens Lauren , Tomczak Jennifer A. , Frietze Seth , Carr Frances E.
Published: April 2023

Pathway Analysis
Figure S6 from Thyroid Hormone Receptor Beta Induces a Tumor-Suppressive Program in Anaplastic Thyroid Cancer
Authors: Bolf Eric L. , Gillis Noelle E. , Davidson Cole D. , Rodriguez Princess D. , Cozzens Lauren , Tomczak Jennifer A. , Frietze Seth , Carr Frances E.
Published: April 2023

Supplemental Figure 6: TRβ Induced a more Differentiated Phenotype. RNA-sequencing data revealed statistically significant increase of the epithelial marker CDH1 and repression of the mesenchymal marker VIM. Although SNAI1 was expressed, no significant changes in expression were observed. n=3, * p<0.05, ***** p<0.0001.
Figure S5 from Thyroid Hormone Receptor Beta Induces a Tumor-Suppressive Program in Anaplastic Thyroid Cancer
Authors: Bolf Eric L. , Gillis Noelle E. , Davidson Cole D. , Rodriguez Princess D. , Cozzens Lauren , Tomczak Jennifer A. , Frietze Seth , Carr Frances E.
Published: April 2023

Supplemental Figure 5: TRβ Alters Expression of Key Cell Cycle Regulators. RNA-sequencing data revealed statistically significant increase of the anti-proliferative gene CDKN1A and repression the pro-proliferative gene MYC. n=3, ** p<0.01, *** p<0.001.
Supplementary Table 4 from Loss of 9p21 Regulatory Hub Promotes Kidney Cancer Progression by Upregulating HOXB13
Authors: Baietti Maria Francesca , Zhao Peihua , Crowther Jonathan , Sewduth Raj Nayan , De Troyer Linde , Debiec-Rychter Maria , Sablina Anna A.
Published: April 2023

Overlap HOXB13 targets
Supplementary Figures 1-7 from Nestin Is Required for Spindle Assembly and Cell-Cycle Progression in Glioblastoma Cells
Authors: Wang Qinglin , Wu Hao , Hu Jian , Fu Haijuan , Qu Yanghui , Yang Yijun , Cai Kathy Q. , Efimov Andrey , Wu Minghua , Yen Tim , Wang Yuan , Yang Zeng-Jie
Published: April 2023

Supplementary Figure 1. Hedgehog pathway is not activated in U251 cells. Supplementary Figure 2. Colony formation from passaged U251 cells after Nestin knockdown. Supplementary Figure 3. GBM cells from PDX undergo apoptosis after Nestin knockdown. Supplementary Figure 4. Nestin deletion causes G2/M arrest and apoptosis in U251 cells. Supplementary Figure 5. Colony formation from U87 cells after transduction with Nestin shRNA. Supplementary Figure 6. No alterations in the mRNA expression of TUBB2A and TUBB2B in U251 cells after Nestin manipulation. Supplementary Figure 7. No alterations in the expression of Nestin mRNA and protein in U251 cells after βII-tubulin knockdown.
Supplementary Table 3 from Loss of 9p21 Regulatory Hub Promotes Kidney Cancer Progression by Upregulating HOXB13
Authors: Baietti Maria Francesca , Zhao Peihua , Crowther Jonathan , Sewduth Raj Nayan , De Troyer Linde , Debiec-Rychter Maria , Sablina Anna A.
Published: April 2023

9p interacting genes
Supplementary Table 1 from RICTOR Amplification Promotes NSCLC Cell Proliferation through Formation and Activation of mTORC2 at the Expense of mTORC1
Authors: Kim Laura C. , Rhee Christopher H. , Chen Jin
Published: April 2023

sgRNA sequences and plasmids
Supplementary Table 2 and Legend from Distinct Biomarker Profiles and TCR Sequence Diversity Characterize the Response to PD-L1 Blockade in a Mouse Melanoma Model
Authors: El Meskini Rajaa , Atkinson Devon , Kulaga Alan , Abdelmaksoud Abdalla , Gumprecht Michelle , Pate Nathan , Hayes Susana , Oberst Michael , Kaplan Ian M. , Raber Patrick , Van Dyke Terry , Sharan Shyam K. , Hollingsworth Robert , Day Chi-Ping , Merlino Glenn , Weaver Ohler Zoë
Published: April 2023

The top differentially expressed genes from Figure 3
Table S1 from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer
Authors: Park Yuri , Baik Seunghan , Ho Charles , Lin Chin-Yo , Chung Sang-Hyuk
Published: April 2023

Description of mouse strains.
Figure S1 from Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer
Authors: Park Yuri , Baik Seunghan , Ho Charles , Lin Chin-Yo , Chung Sang-Hyuk
Published: April 2023

H&E images of cancer and epithelium.
Supplementary Figures 1-6 from HDAC3 Is Required for XPC Recruitment and Nucleotide Excision Repair of DNA Damage Induced by UV Irradiation
Authors: Nishimoto Koji , Niida Hiroyuki , Uchida Chiharu , Ohhata Tatsuya , Kitagawa Kyoko , Motegi Akira , Suda Takafumi , Kitagawa Masatoshi
Published: April 2023

Supplementary Figure S1. Depletion of HDAC3 increases UV sensitivity and delays CPD removal. Supplementary Figure S2. HDAC3 does not interact with NER factors in the presence or absence UV irradiation. Supplementary Figure S3. HDAC3 facilitates XPC and TFIIH recruitment in U2OS cells. Supplementary Figure S4. Most XPC localizes to chromatin in the absence of DNA damage. Supplementary Figure S5. Depletion of HDAC3 induces continuous checkpoint activation in response to DNA damage. Supplementary Figure S6. Representative immunostaining of cells after local UV irradiation in Figure 6B.
File S5 from Circulating Tumor Cell Genomic Evolution and Hormone Therapy Outcomes in Men with Metastatic Castration-Resistant Prostate Cancer
Authors: Gupta Santosh , Halabi Susan , Kemeny Gabor , Anand Monika , Giannakakou Paraskevi , Nanus David M. , George Daniel J. , Gregory Simon G. , Armstrong Andrew J.
Published: April 2023

The table representing the top somatic mutations validated in the COSMIC database were compared between baseline sensitive (N=5) and resistant CTC-DNA (N=5).
File S2 from Circulating Tumor Cell Genomic Evolution and Hormone Therapy Outcomes in Men with Metastatic Castration-Resistant Prostate Cancer
Authors: Gupta Santosh , Halabi Susan , Kemeny Gabor , Anand Monika , Giannakakou Paraskevi , Nanus David M. , George Daniel J. , Gregory Simon G. , Armstrong Andrew J.
Published: April 2023

Commonly altered genes present in >=40% of progression cases (N=28).
Figure S4 from Circulating Tumor Cell Genomic Evolution and Hormone Therapy Outcomes in Men with Metastatic Castration-Resistant Prostate Cancer
Authors: Gupta Santosh , Halabi Susan , Kemeny Gabor , Anand Monika , Giannakakou Paraskevi , Nanus David M. , George Daniel J. , Gregory Simon G. , Armstrong Andrew J.
Published: April 2023

Genomic-wide CNAs analysis in CTCs in the radium-223 trial. Top genomic gain (A) and loss (B) detected in the PROPHECY trial were independently validated in the radium-223 trial CTCs DNA (N=14 patients) study. Before radium-223 treatment, these patients were priorly treated with enza/abi.
Figure S3 from Circulating Tumor Cell Genomic Evolution and Hormone Therapy Outcomes in Men with Metastatic Castration-Resistant Prostate Cancer
Authors: Gupta Santosh , Halabi Susan , Kemeny Gabor , Anand Monika , Giannakakou Paraskevi , Nanus David M. , George Daniel J. , Gregory Simon G. , Armstrong Andrew J.
Published: April 2023

Comparing copy number alterations in CTCs DNA over time. A heat map shows the copy number alterations of sixty genes in 25 paired baseline and progression CTCs DNA, longitudinally at individual patient-level. Genomic copy gain is presented in red, loss in blue, and no change in white color.
Supplementary Data 2 from Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung Cancer
Authors: Mirhadi Shideh , Zhang Wen , Pham Nhu-An , Karimzadeh Fereshteh , Pintilie Melania , Tong Jiefei , Taylor Paul , Krieger Jonathan , Pitcher Bethany , Sykes Jenna , Wybenga-Groot Leanne , Fladd Christopher , Xu Jing , Wang Tao , Cabanero Michael , Li Ming , Weiss Jessica , Sakashita Shingo , Zaslaver Olga , Yu Man , Caudy Amy A. , St-Pierre Julie , Hawkins Cynthia , Kislinger Thomas , Liu Geoffrey , Shepherd Frances A. , Tsao Ming-Sound , Moran Michael F.
Published: April 2023

Differentially expressed proteins and pathways analyses
Supplementary Data from GAS6/AXL Inhibition Enhances Ovarian Cancer Sensitivity to Chemotherapy and PARP Inhibition through Increased DNA Damage and Enhanced Replication Stress
Authors: Mullen Mary M. , Lomonosova Elena , Toboni Michael D. , Oplt Alyssa , Cybulla Emily , Blachut Barbara , Zhao Peinan , Noia Hollie , Wilke Daniel , Rankin Erinn B. , Kuroki Lindsay M. , Hagemann Andrea R. , Hagemann Ian S. , McCourt Carolyn K. , Thaker Premal H. , Mutch David G. , Powell Matthew A. , Mosammaparast Nima , Vindigni Alessandro , Fuh Katherine C.
Published: April 2023

Supplementary Table S1. Comprehensive radiologic, surgical, and pathologic scoring system used to evaluate tumor response to neoadjuvant chemotherapy. Supplementary Table S2. Summary of antibodies used. Supplementary Table S3. Disease characteristics of ovarian cancer patients receiving neoadjuvant chemotherapy and undergoing interval cytoreductive surgery stratified by chemoresponse. Supplementary Table S4. Disease characteristics of ovarian cancer patients receiving neoadjuvant chemotherapy and undergoing interval cytoreductive surgery stratified by high and low serum GAS6 expression prior to neoadjuvant chemotherapy. Supplementary Figure S1. RAD51 foci formation in irradiated ovarian cancer cells. Supplementary Figure S2. GAS6 and AXL expression in four ovarian cancer cell lines. Supplementary Figure S3. Mean combination indexes and dose response curves for paclitaxel and AVB-500 in three ovarian cancer cell lines. Supplementary Figure S4. GAS6/AXL inhibitor AVB-500 improves response to carboplatin and decreases tumor burden in PDX mouse model of ovarian cancer. Supplementary Figure S5. GAS6/AXL inhibitor AVB-500 decreases GAS6 and pAKT expression in mouse tumors. Supplementary Figure S6. Cleaved Caspase 3 levels in OVCAR8 ovarian cancer cells at 24 and 48 hours of treatment. Supplementary Figure S7. Treatment with AVB-500 increases DNA damage. Supplementary Figure S8. Treatment with AVB-500 decreases activation of AKT and does not affect protein expression of 53BP1, AXL, or RAD51. Supplementary Figure S9. Treatment with carboplatin plus AVB-500 decreases pATM and increases pCHK1. Supplementary Figure S10. Treatment with AVB-500 decreases RPA binding and does not affect the cell cycle. Supplementary Figure S11. Treatment with AVB-500 in addition to olaparib increases DNA damage and decreases homologous recombination. Supplementary Figure S12. Proposed mechanism of AVB-500 and carboplatin increasing DNA damage through replication fork perturbation.
Supplementary Data from Inhibiting WEE1 and IKK-RELA Crosstalk Overcomes TNFα Resistance in Head and Neck Cancers
Authors: Hu Zhengbo , Viswanathan Ramya , Cheng Hui , Chen Jianghong , Yang Xinping , Huynh Angel , Clavijo Paul , An Yi , Robbins Yvette , Silvin Christopher , Allen Clint , Ormanoglu Pinar , Martin Scott , Cornelius Shaleeka , Saleh Anthony , Chen Zhong , Van Waes Carter , Morgan Ethan L.
Published: April 2023

Supplementary Data from Inhibiting WEE1 and IKK-RELA Crosstalk Overcomes TNFα Resistance in Head and Neck Cancers
Supplementary Figure from Distinct Transcriptional Programs in Ascitic and Solid Cancer Cells Induce Different Responses to Chemotherapy in High-Grade Serous Ovarian Cancer
Authors: Loret Nele , Vandamme Niels , De Coninck Jordy , Taminau Joachim , De Clercq Kato , Blancke Gillian , Jonckheere Sven , Goossens Steven , Lemeire Kelly , De Prijck Sofie , Verstaen Kevin , Seurinck Ruth , Van Dorpe Jo , Weyers Steven , Denys Hannelore , Van de Vijver Koen , Lambrecht Bart N. , Tummers Philippe , Saeys Yvan , Berx Geert
Published: April 2023

Supplementary Figure from Distinct Transcriptional Programs in Ascitic and Solid Cancer Cells Induce Different Responses to Chemotherapy in High-Grade Serous Ovarian Cancer
Supplementary Figure from MOB3A Bypasses BRAF and RAS Oncogene-Induced Senescence by Engaging the Hippo Pathway
Authors: Dutchak Kendall , Garnett Sam , Nicoll Mary , de Bruyns Angeline , Dankort David
Published: April 2023

Supplementary Figure from MOB3A Bypasses BRAF and RAS Oncogene-Induced Senescence by Engaging the Hippo Pathway
Supplementary Figure from EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal
Authors: Li Haojie , Fu Xuhong , Zhao Junjie , Li Chen , Li Lingmeng , Xia Peiyan , Guo Jianping , Wei Wenyi , Zeng Rong , Wu Jiarui , Sun Yihong , Huang Liyu , Wang Xuefei
Published: April 2023

Supplementary Figure from EXOC4 Promotes Diffuse-Type Gastric Cancer Metastasis via Activating FAK Signal
Supplementary Table from MYC-Induced Upregulation of Lncrna ELFN1-AS1 Contributes to Tumor Growth in Colorectal Cancer via Epigenetically Silencing TPM1
Authors: Li Chenyao , Hong Sen , Hu Han , Liu Tao , Yan Guoqiang , Sun Di
Published: April 2023

Supplementary Table from MYC-Induced Upregulation of Lncrna ELFN1-AS1 Contributes to Tumor Growth in Colorectal Cancer via Epigenetically Silencing TPM1
Supplementary Figure from MYC-Induced Upregulation of Lncrna ELFN1-AS1 Contributes to Tumor Growth in Colorectal Cancer via Epigenetically Silencing TPM1
Authors: Li Chenyao , Hong Sen , Hu Han , Liu Tao , Yan Guoqiang , Sun Di
Published: April 2023

Supplementary Figure from MYC-Induced Upregulation of Lncrna ELFN1-AS1 Contributes to Tumor Growth in Colorectal Cancer via Epigenetically Silencing TPM1
Supplementary Data from KDM6A Depletion in Breast Epithelial Cells Leads to Reduced Sensitivity to Anticancer Agents and Increased TGFβ Activity
Authors: Xiao Jin-Fen , Kua Ley-Fang , Ding Ling-Wen , Sun Qiao-Yang , Myint Khine Nyein , Chia Xiu-Rong , Venkatachalam Nachiyappan , Loh Xinyi , Duex Jason E. , Neang Vanessa , Zhou Siqin , Li Ying , Yang Henry , Koeffler H. Phillip , Theodorescu Dan
Published: April 2023

Supplementary Data from KDM6A Depletion in Breast Epithelial Cells Leads to Reduced Sensitivity to Anticancer Agents and Increased TGFβ Activity
Pintotable1.xlsx from Clinical and Functional Significance of TP53 Exon 4–Intron 4 Splice Junction Variants
Authors: Pinto Emilia M. , Maxwell Kara N. , Halalsheh Hadeel , Phillips Aaron , Powers Jacquelyn , MacFarland Suzanne , Walsh Michael F. , Breen Kelsey , Formiga Maria N. , Kriwacki Richard , Nichols Kim E. , Mostafavi Roya , Wang Jinling , Clay Michael R. , Rodriguez-Galindo Carlos , Ribeiro Raul C. , Zambetti Gerard P.
Published: April 2023

Pintotable1.xlsx
Table S1a. Cohort characteristicsTable S1b. Frequencies and features of TP53 variants at codon 125 in public databasesTable S1c. Annotation and interpretation of TP53 variants at codon 125 and surrounding basesTable S1d. Splice site predictionTable S1e. Primers sequences for mutagenesis constructs and cDNA sequencing Table S1f. STR profiling of Saos-2 and H1299 cell lines
Supplementary Data from Antizyme Inhibitor 1 Regulates Matrikine Expression and Enhances the Metastatic Potential of Aggressive Primary Prostate Cancer
Authors: Van den Broeck Thomas , Moris Lisa , Gevaert Thomas , Davicioni Elai , Boeckx Bram , Lambrechts Diether , Helsen Christine , Handle Florian , Ghesquière Bart , Soenen Stefaan , Smeets Elien , Eerlings Roy , El Kharraz Sarah , Devlies Wout , Karnes R. Jeffrey , Lotan Tamara , Van Poppel Hendrik , Joniau Steven , Claessens Frank
Published: April 2023

Supplementary Data from Antizyme Inhibitor 1 Regulates Matrikine Expression and Enhances the Metastatic Potential of Aggressive Primary Prostate Cancer
Supplementary Table 4 from Downregulation of iNOS/NO Promotes Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
Authors: Du Qiang , Liu Silvia , Dong Kun , Cui Xiao , Luo Jing , Geller David A.
Published: April 2023

KD of iNOS regulated gene expressions of selected stem-cell markers in CRC cells
Supplementary Table 3 from Downregulation of iNOS/NO Promotes Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
Authors: Du Qiang , Liu Silvia , Dong Kun , Cui Xiao , Luo Jing , Geller David A.
Published: April 2023

KD of iNOS regulated gene expressions of selected EMT markers
Supplementary Table 2 from Downregulation of iNOS/NO Promotes Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
Authors: Du Qiang , Liu Silvia , Dong Kun , Cui Xiao , Luo Jing , Geller David A.
Published: April 2023

Reference genes regulated by downregulation of iNOS
Table S4 from Hypertension Promotes the Proliferation and Migration of ccRCC Cells by Downregulation of TIMP3 in Tumor Endothelial Cells through the miR-21–5p/TGFBR2/P38/EGR1 Axis
Authors: Wang Chenguang , Xu Haibo , Liao Xinhui , Wang Weiming , Wu Wanjun , Li Wujiao , Niu Liman , Li Zhichao , Li Aolin , Sun Yangyang , Huang Weiren , Song Fei
Published: April 2023

Top 100 genes that have similar expression patterns with TIMP3 in ccRCC by GEPIA2
Supplementary Table S5 from BAP1 Loss Is Associated with Higher ASS1 Expression in Epithelioid Mesothelioma: Implications for Therapeutic Stratification
Authors: Barnett Sarah E. , Kenyani Jenna , Tripari Martina , Butt Zohra , Grosman Rudi , Querques Francesca , Shaw Liam , Silva Luisa C. , Goate Zoe , Marciniak Stefan J. , Rassl Doris M. , Jackson Richard , Lian Lu-Yun , Szlosarek Peter W. , Sacco Joseph J. , Coulson Judy M.
Published: April 2023

Patient scoring and survival summary
Supplementary Figure Legends from The Elongin BC Complex Negatively Regulates AXL and Marks a Differentiated Phenotype in Melanoma
Authors: Schieven Sebastiaan M. , Traets Joleen J.H. , Vliet Alex v. , Baalen Martijn v. , Song Ji-Ying , Guimaraes Marcos Da Silva , Kuilman Thomas , Peeper Daniel S.
Published: April 2023

Supplementary Figure Legends 1-7
Supplementary Figures 1-7 from ATM Regulation of the Cohesin Complex Is Required for Repression of DNA Replication and Transcription in the Vicinity of DNA Double-Strand Breaks
Authors: Bass Thomas E. , Fleenor Donald E. , Burrell Paige E. , Kastan Michael B.
Published: April 2023

S1. Identification of novel ATM-interactors using BioID.
S2.NIPBL, PDS5A, and PDS5B are required for chromosomal stability and viability after IR.
S3. Mutation of Fok1 nuclease domain blocks DSB formation.
S4. Low dose IR causes suppression of DNA replication within the vicinity of the DSBs.
S5. Fok1-induced DSBs do not result in a decrease in nuclear DNA replication.
S6. Repression of DNA replication around DSBs is dependent on ATM and not ATR or DNAPK.
S7. ATM phosphorylation of cohesin is required for repression of DNA replication within the vicinity of a DSB.
Video 8 from Autocrine Fibronectin Inhibits Breast Cancer Metastasis
Authors: Shinde Aparna , Libring Sarah , Alpsoy Aktan , Abdullah Ammara , Schaber James A. , Solorio Luis , Wendt Michael K.
Published: April 2023

FN-depleted Ca1h cells (shFN32) cannot facilitate the migration of Ca1a cells (labeled in red) off of the solid support of the scaffold.
Video 6 from Autocrine Fibronectin Inhibits Breast Cancer Metastasis
Authors: Shinde Aparna , Libring Sarah , Alpsoy Aktan , Abdullah Ammara , Schaber James A. , Solorio Luis , Wendt Michael K.
Published: April 2023

Ca1a cells (labeled by d-tomato) can migrate off of the solid support scaffold on FN-expressing Ca1h cells.
Data from Targeting Unc51-like Autophagy Activating Kinase 1 (ULK1) Overcomes Adaptive Drug Resistance in Acute Myelogenous Leukemia
Authors: Bhattacharya Seemana , Piya Sujan , Ma Huaxian , Sharma Priyanka , Zhang Qi , Baran Natalia , Ruvolo Vivian R. , McQueen Teresa , Davis R. Eric , Pourebrahim Rasoul , Konopleva Marina , Kantarjian Hagop , Cosford Nicholas D. P. , Andreeff Michael , Borthakur Gautam
Published: April 2023

Abstract
Despite effective new therapies, adaptive resistance remains the main obstacle in acute myelogenous leukemia (AML) therapy. Autophagy induction is a key mechanism for adaptive resistance. Leukemic blasts at diagnosis express higher levels of the apical autophagy kinase ULK1 compared with normal hematopoietic cells. Exposure to chemotherapy and targeted agents upregulate ULK1, hence we hypothesize that developing ULK1 inhibitors may present the unique opportunity for clinical translation of autophagy inhibition. Accordingly, we demonstrate that ULK1 inhibition, by genetic and pharmacologic means, suppresses treatment-induced autophagy, overcomes adaptive drug-resistance, and synergizes with chemotherapy and emerging antileukemia agents like venetoclax (ABT-199). The study next aims at exploring the underlying mechanisms. Mechanistically, ULK1 inhibition downregulates MCL1 antiapoptotic gene, impairs mitochondrial function and downregulates components of the CD44-xCT system, resulting in impaired reactive oxygen species (ROS) mitigation, DNA damage, and apoptosis. For further validation, several mouse models of AML were generated. In these mouse models, ULK1 deficiency impaired leukemic cell homing and engraftment, delayed disease progression, and improved survival. Therefore, in the study, we validated our hypothesis and identified ULK1 as an important mediator of adaptive resistance to therapy and an ideal candidate for combination therapy in AML. Therefore, we propose ULK1 inhibition as a therapeutically relevant treatment option to overcome adaptive drug-resistance in AML.
Implications:
ULK1 drives a cell-intrinsic adaptive resistance in AML and targeting ULK1-mediated autophagy can synergize with existing and emerging AML therapies to overcome drug-resistance and induce apoptosis.
Data from Scaffolding Protein Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Regulates MAPK Inhibition Responsiveness in Pancreas Cancer via Crosstalk with AKT Signaling
Authors: Li Dandan , Miermont Anne M. , Sable Rushikesh , Quadri Humair S. , Mathews Griner Lesley A. , Martin Scott E. , Odzorig Taivan , De Soumita , Ferrer Marc , Powers Astin S. , Hewitt Stephen M. , Rudloff Udo
Published: April 2023

Abstract
Combinatorial molecular therapy in pancreatic ductal adenocarcinoma (PDAC) has yielded largely disappointing results in clinical testing to-date as a multitude of adaptive resistance mechanisms is making selection of patients via molecular markers that capture essential, intersecting signaling routes challenging. Here, we report the scaffolding protein connector enhancer of kinase suppressor of Ras 1 (CNKSR1) as mediator of resistance to MAPK (MEK) inhibition. MEK inhibition in CNKSR1high cancer cells induces translocation of CNKSR1 to the plasma membrane where the scaffolding protein interacts with and stabilizes the phosphorylated form of AKT. CNKSR1-mediated AKT activation following MEK inhibition was associated with increased cellular p-PRAS40 levels and reduced nuclear translocation and cellular levels of FoxO1, a negative regulator of AKT signaling. In clinical PDAC specimens, high cytoplasmatic CNKSR1 levels correlated with increased cellular phospho-AKT and mTOR levels. Pharmacological co-blockade of AKT and MEK ranked top in induced synergies with MEK inhibition in CNKSR1high pancreas cancer cells among other inhibitor combinations targeting known CNKSR1 signaling. In vivo, CNKSR1high pancreatic tumors treated with AKT and MEK inhibitors showed improved outcome in the combination arm compared with single-agent treatment, an effect not observed in CNKSR1low models.

Our results identify CNKSR1 as regulator of adaptive resistance to MEK inhibition by promoting crosstalk to AKT signaling via a scaffolding function for the phosphorylated form of AKT. CNSKR1 expression might be a possible molecular marker to enrich patients for future AKT–MEK inhibitor precision medicine studies.
Implications:
The CNKSR1 scaffold, identified within an RNAi screen as a novel mediator of resistance to MEK inhibition in pancreas cancer, connects the MAPK pathway and AKT signaling and may be adopted as a biomarker to select patients for combined MEK AKT blockade.
Supplementary Figure 1 from Direct Targeting of MEK1/2 and RSK2 by Silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell Growth
Authors: Lee Mee-Hyun , Huang Zunnan , Kim Dong Joon , Kim Sung-Hyun , Kim Myoung Ok , Lee Sung-Young , Xie Hua , Park Si Jun , Kim Jae Young , Kundu Joydeb Kumar , Bode Ann M. , Surh Young-Joon , Dong Zigang
Published: April 2023

PDF file - 29K, The protein levels of total and phosphorylated BRAF, MEK1/2, and RSK2 in SK-MEL-5, SK-MEL-28, and SK-MEL-2 melanoma cells and NHDF cells, a normal control cell line.
Supplementary Table 1 from Identification of Actively Translated mRNA Transcripts in a Rat Model of Early-Stage Colon Carcinogenesis
Authors: Davidson Laurie A. , Wang Naisyin , Ivanov Ivan , Goldsby Jennifer , Lupton Joanne R. , Chapkin Robert S.
Published: April 2023

Supplementary Table 1 from Identification of Actively Translated mRNA Transcripts in a Rat Model of Early-Stage Colon Carcinogenesis
Supplementary Appendix 1 from Increased Levels of Urinary PGE-M, a Biomarker of Inflammation, Occur in Association with Obesity, Aging, and Lung Metastases in Patients with Breast Cancer
Authors: Morris Patrick G. , Zhou Xi Kathy , Milne Ginger L. , Goldstein Daniel , Hawks Laura C. , Dang Chau T. , Modi Shanu , Fornier Monica N. , Hudis Clifford A. , Dannenberg Andrew J.
Published: April 2023

PDF file - 30K, Study questionnaire used to collect smoking and NSAID data.
Supplementary Figure 3A from Mortality in the Randomized, Controlled Lung Intergroup Trial of Isotretinoin
Authors: Lee J. Jack , Feng Lei , Reshef Daniel S. , Sabichi Anita L. , Williams Brendell , Rinsurongkawong Waree , Wistuba Ignacio I. , Lotan Reuben , Lippman Scott M.
Published: April 2023

Supplementary Figure 3A from Mortality in the Randomized, Controlled Lung Intergroup Trial of Isotretinoin
Perspective on this Article from Deguelin Inhibits Growth of Breast Cancer Cells by Modulating the Expression of Key Members of the Wnt Signaling Pathway
Authors: Murillo Genoveva , Peng Xinjian , Torres Karen E.O. , Mehta Rajendra G.
Published: April 2023

Perspective on this Article from Deguelin Inhibits Growth of Breast Cancer Cells by Modulating the Expression of Key Members of the Wnt Signaling Pathway
Supplementary Figure 3 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
Authors: Fordyce Colleen , Fessenden Tim , Pickering Curtis , Jung Jason , Singla Veena , Berman Hal , Tlsty Thea
Published: April 2023

Supplementary Figure 3 from DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and Lesions
Supplementary Table 1 from Cyclooxygenase-2 Generates the Endogenous Mutagen trans-4-Hydroxy-2-nonenal in Enterococcus faecalis–Infected Macrophages
Authors: Wang Xingmin , Allen Toby D. , Yang Yonghong , Moore Danny R. , Huycke Mark M.
Published: April 2023

PDF file - 45K, Primers, PCR product size, and cycling parameters
Supplementary Figures 1-6 from Metformin Prevents Liver Tumorigenesis by Inhibiting Pathways Driving Hepatic Lipogenesis
Authors: Bhalla Kavita , Hwang Bor Jang , Dewi Ruby E. , Twaddel William , Goloubeva Olga G. , Wong Kwok-Kin , Saxena Neeraj K. , Biswal Shyam , Girnun Geoffrey D.
Published: April 2023

PDF file - 343K
Related Article from Preventing Cancer with Vaccines: Progress in the Global Control of Cancer
Authors: Kane Mark A.
Published: April 2023

Related Article from Preventing Cancer with Vaccines: Progress in the Global Control of Cancer
Supplementary Data from Association between Urinary Prostaglandin E2 Metabolite and Breast Cancer Risk: A Prospective, Case–Cohort Study of Postmenopausal Women
Authors: Kim Sangmi , Taylor Jack A. , Milne Ginger L. , Sandler Dale P.
Published: April 2023

Supplementary Data from Association between Urinary Prostaglandin E2 Metabolite and Breast Cancer Risk: A Prospective, Case–Cohort Study of Postmenopausal Women
Supplementary Figure 1 from Dietary Fish Oil Promotes Colonic Apoptosis and Mitochondrial Proton Leak in Oxidatively Stressed Mice
Authors: Fan Yang-Yi , Ran Qitao , Toyokuni Shinya , Okazaki Yasumasa , Callaway Evelyn S. , Lupton Joanne R. , Chapkin Robert S.
Published: April 2023

PDF file - 148K
Perspective on this Article from Synergistic Effects of Combined Phytochemicals and Skin Cancer Prevention in SENCAR Mice
Authors: Kowalczyk Magdalena C. , Kowalczyk Piotr , Tolstykh Olga , Hanausek Margaret , Walaszek Zbigniew , Slaga Thomas J.
Published: April 2023

Perspective on this Article from Synergistic Effects of Combined Phytochemicals and Skin Cancer Prevention in SENCAR Mice
Supplementary Table 2 from MAPRE1 as a Plasma Biomarker for Early-Stage Colorectal Cancer and Adenomas
Authors: Taguchi Ayumu , Rho Jung-hyun , Yan Qingxiang , Zhang Yuzheng , Zhao Yang , Xu Hanwen , Tripathi Satyendra Chandra , Wang Hong , Brenner Dean E. , Kucherlapati Melanie , Kucherlapati Raju , Boutin Adam T. , Wang Y. Alan , DePinho Ronald A. , Feng Ziding , Lampe Paul D. , Hanash Samir M.
Published: April 2023

Case/control ratios of 22 proteins selected for antibody microarrays in pre-diagnostic CRC plasma samples from the Women's Health Initiative cohort
Supplementary Figure 1 from Colorectal Adenoma Stem-like Cell Populations: Associations with Adenoma Characteristics and Metachronous Colorectal Neoplasia
Authors: Bartley Angela N. , Parikh Nila , Hsu Chiu-Hsieh , Roe Denise J. , Buckmeier Julie A. , Corley Lynda , Phipps Ron A. , Gallick Gary , Lance Peter , Thompson Patricia A. , Hamilton Stanley R.
Published: April 2023

PDF file - 636K, Representative images of ALDH1 staining and enumeration by Aperio Genie with color.
Supplementary Figure 1 from MAPRE1 as a Plasma Biomarker for Early-Stage Colorectal Cancer and Adenomas
Authors: Taguchi Ayumu , Rho Jung-hyun , Yan Qingxiang , Zhang Yuzheng , Zhao Yang , Xu Hanwen , Tripathi Satyendra Chandra , Wang Hong , Brenner Dean E. , Kucherlapati Melanie , Kucherlapati Raju , Boutin Adam T. , Wang Y. Alan , DePinho Ronald A. , Feng Ziding , Lampe Paul D. , Hanash Samir M.
Published: April 2023

MAPRE1 protein expression in tissue microarray
Supplementary Figure legends from Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis
Authors: Shukla Samriddhi , Khan Sajid , Kumar Sudhir , Sinha Sonam , Farhan Mohd. , Bora Himangsu K. , Maurya Rakesh , Meeran Syed Musthapa
Published: April 2023

Supplementary Figure legends. Supplementary Figure S1-S3 legends
Supplementary Table 1 from New Role of (−)-Epicatechin in Enhancing the Induction of Growth Inhibition and Apoptosis in Human Lung Cancer Cells by Curcumin
Authors: Saha Achinto , Kuzuhara Takashi , Echigo Noriko , Suganuma Masami , Fujiki Hirota
Published: April 2023

Supplementary Table 1 from New Role of (−)-Epicatechin in Enhancing the Induction of Growth Inhibition and Apoptosis in Human Lung Cancer Cells by Curcumin