bluuebunny/crossref_metadata_2025 huggingface dataset:
The influence of whole-body cryotherapy or winter swimming on the lipid profile and selected adipokines
Authors: Ptaszek Bartłomiej , Podsiadło Szymon , Wójcik Artur , Czerwińska-Ledwig Olga , Teległów Aneta
Published: October 2023

Purpose

The aim of this study was to investigate the effect of a series of 20 whole-body cryotherapy (WBC) sessions and 20 winter swimming sessions on the lipid profile and selected adipokines.

Materials/methods

The experimental group consisted of 30 people who underwent a series of WBC treatments and 30 people who underwent a winter swimming. The control group consisted of 30 people - without intervention. Study 1: on the day of the commencement of whole-body cryotherapy / at the beginning of the winter swimming season; and Study 2: after a series of 20 cryotherapy sessions / at the end of the winter swimming season. The control group was also tested twice (4-week break). There were 20 WBC treatments − 5 times a week (4 weeks) and 20 cold water baths - once a week (20 weeks).

Results

A statistically significant increase in the concentration of adiponectin, resistin and leptin in women and resistin and leptin in men was observed after the winter swimming season. Differences were also found in the second study between the groups of women using WBC and the control group, as well as the groups of women swimming and the control group. In men, however, these differences were observed in WBC and the control group. The significance level of α = 0.05 was adopted in the analyzes.

Conclusions

The use of WBC may changes in the lipid profile and selected adipokines in men. Regular winter swimming may changes of selected adipokines in both women and men.
Influence of cuff stiffness on hemodynamics and perceived cuff pressure in the upper extremities in males and females: implications for practical blood flow restriction training
Authors: Bielitzki Robert , Behrendt Tom , Nguyen Toan , Behrens Martin , Malczewski Victoria , Franz Alexander , Schega Lutz
Published: October 2023

Background

Practical blood flow restriction (pBFR) during exercise is a cost-saving alternative to traditional blood flow restriction using pneumatic cuffs, particularly when exercising in a group setting. Depending on the pBFR technique, several factors (e.g., cuff width, limb circumference) have already been shown to be of importance when applying the pBFR pressure. Given that elastic cuffs are often used for pBFR, the cuff stiffness might be an additional influencing factor. Therefore, the present study compared the acute effects of three elastic cuffs with identical width but different stiffness (high stiffness (HS), medium stiffness (MS), and low stiffness (LS)) on hemodynamic measures and perceived cuff pressure at rest.

Methods

In a randomized, counter-balanced cross-over study, 36 young and normotensive participants completed three experimental trials. After a 10-min rest period in supine position, the cuff was loosely and proximally applied to the right upper arm. Following baseline data recording, the cuff was successively tightened in 10%-increments with respect to the limb circumference (%overlap) until arterial blood flow was occluded. At baseline and during each %overlap, systolic peak blood flow velocity of the brachial artery, rating of perceived cuff pressure, as well as muscle oxygen saturation and total hemoglobin concentration of the biceps brachii muscle were recorded.

Results

The %overlap required to occlude arterial blood flow was different between the three cuffs (HS: 30.9 ± 3.8%, MS: 43.9 ± 6.1%, LS: 54.5 ± 8.3%). Furthermore, at 30% overlap, systolic peak blood flow velocity was lower when applying the HS (9.0 ± 10.9 cm∙s− 1) compared to MS (48.9 ± 21.9 cm∙s− 1) and LS cuff (62.9 ± 19.1 cm∙s− 1). Rating of perceived cuff pressure at 30% overlap was higher when using the HS (6.5 ± 1.5 arbitrary unit (a.u.)) compared to MS (5.1 ± 1.4 a.u.) and LS cuff (4.9 ± 1.5 a.u.) with no difference between the MS and LS cuff. However, muscle oxygen saturation and total hemoglobin concentration were not different between the three cuffs.

Conclusions

The present study revealed that the cuff stiffness influenced blood flow velocity and arterial occlusion pressure. Therefore, cuff stiffness seems an important factor for the application of pBFR.
Incidence of asymptomatic catheter-related thrombosis in intensive care unit patients: a prospective cohort study
Authors: Abbruzzese Chiara , Guzzardella Amedeo , Consonni Dario , Turconi Gloria , Bonetti Claudia , Brioni Matteo , Panigada Mauro , Grasselli Giacomo
Published: October 2023

Background

Catheter-related thrombosis (CRT) incidence, rate, and risk factors vary in literature due to differences in populations, catheters, diagnostic methods, and statistical approaches.

The aim of this single-center, prospective, observational study was to assess incidence, incidence rate (IR), cumulative incidence, and risk factors by means of IR ratio (IRR) of asymptomatic CRT in a non-oncologic Intensive Care Unit (ICU) population. CRT development was assessed daily by means of ultrasound screening. The proportions of patients and catheters developing CRT and CRT incidence rates, expressed as the number of events per catheter-days (cd), were calculated. Kalbfleisch and Prentice’s method was used to estimate the cumulative incidence of CRTs. Univariate and multivariable Poisson regression models were fitted to calculate IRR in risk factors analysis.

Results

Fifty (25%, 95% CI 19–31) out of 203 included patients, and 52 (14%, 95% CI 11–18) out of 375 catheters inserted developed CRT [IR 17.7 (13.5–23.2) CRTs/1000*cd], after 5 [3–10] days from insertion. Forty-six CRTs (88%) were partial thrombosis. All CRTs remained asymptomatic. Obesity and ECMO support were patient-related protective factors [IRR 0.24 (0.10–0.60), p = 0.002 and 0.05 (0.01–0.50), p = 0.011, respectively]. The internal jugular vein had higher CRT IR than other sites [20.1 vs. 5.9 CRTs/1000*cd, IRR 4.22 (1.22–14.63), p = 0.023]. Pulmonary artery catheter and left-side cannulation were catheter-related risk factors [IRR 4.24 (2.00–9.00), p < 0.001 vs. central venous catheters; IRR 2.69 (1.45–4.98), p = 0.002 vs. right cannulation, respectively]. No statistically significant effect of the number of simultaneously inserted catheters [IRR 1.11 (0.64–1.94), p = 0.708] and of the catheterization length [IRR 1.09 (0.97–1.22), p = 0.155] was detected. The ICU length of stay was longer in CRT patients (20 [15–31] vs. 6 [4–14] days, p < 0.001), while no difference in mortality was observed.

Conclusions

CRTs are frequent but rarely symptomatic. This study suggests that obesity and ECMO are protective factors, while pulmonary artery catheter, internal jugular vein and left-side positioning are risk factors for CRT.
Explicit solutions of conjugate, periodic, time-varying Sylvester equations
Authors: Ma Li , Chang Rui , Han Mengqi , Jiao Yongmei
Published: October 2023

Solutions of a group of conjugate time-varying matrix equations are discussed in this paper. Through mathematical derivation, the solutions to this group of equations are equivalent to the solutions to a class of conjugate time-invariant matrix equations. Further, the related conditions of solvability are obtained and the general explicit solutions are represented by using quasicontrollability and quasiobservability matrices. A detailed algorithm is presented to make the calculation process clear, and the effectiveness of the algorithm is verified by a concrete example. The proposed algorithm can provide complete solutions to the considered equation in explicit parametric form and its main computation includes solving an ordinary linear algebraic equation and some matrix multiplication operations.
Micro, small and medium enterprises and their linkage with key actors in Ethiopia: developing entrepreneurial ecosystem mapping
Authors: Abate Tadesse Wudu , Sheferaw Henok Ezezew
Published: October 2023

Since micro, small, and medium enterprises (MSMEs) are a basic source of income and employment opportunities for the least developed countries, more emphasis has recently been given to those enterprises, and a number of research studies have been conducted. Ethiopia, as one of the Least Developed countries, could also benefit from those MSMEs if the sector is supported enough. Accordingly, this research is conducted to identify the basic determinants of the performance of MSMEs in Ethiopia and to try to develop an entrepreneurial ecosystem mapping to connect those enterprises with the concerned stakeholders, which can contribute to the improvement of the performance of MSMEs. Primary data from randomly selected 400 sampled enterprises is analyzed using ordered logistic regression, and data collected from stakeholder interviews is analyzed using descriptive analysis to develop the ecosystem mapping. Accordingly, academic institutions, such as universities, financial institutions, such as banks and credit associations, non-governmental organizations, such as GIZ and Reach for Change, and government organizations are important actors in entrepreneurship in Ethiopia. Finally, the result of the ordered logit model indicates that access to finance, training, and raw materials, experience, level of education, and sectoral dummy are statistically significant factors that affect the performance of MSMEs. Based on the results, we recommend the government of Ethiopia give more emphasis to MSMEs in different forms, such as providing support in the form of financial, training, market, and raw material linkages.
From big data to smart data: a sample gradient descent approach for machine learning
Authors: Ganie Aadil Gani , Dadvandipour Samad
Published: October 2023

This research paper presents an innovative approach to gradient descent known as ‘‘Sample Gradient Descent’’. This method is a modification of the conventional batch gradient descent algorithm, which is often associated with space and time complexity issues. The proposed approach involves the selection of a representative sample of data, which is subsequently subjected to batch gradient descent. The selection of this sample is a crucial task, as it must accurately represent the entire dataset. To achieve this, the study employs the use of Principle Component Analysis (PCA), which is applied to the training data, with a condition that only those rows and columns of data that explain 90% of the overall variance are retained. This approach results in a convex loss function, where a global minimum can be readily attained. Our results indicate that the proposed method offers faster convergence rates, with reduced computation times, when compared to the conventional batch gradient descent algorithm. These findings demonstrate the potential utility of the ‘‘Sample Gradient Descent’’ technique in various domains, ranging from machine learning to optimization problems. In our experiments, both approaches were run for 30 epochs, with each epoch taking approximately 3.41 s. Notably, our ‘‘Sample Gradient Descent’’ approach exhibited remarkable performance, converging in just 8 epochs, while the conventional batch gradient descent algorithm required 20 epochs to achieve convergence. This substantial difference in convergence rates, along with reduced computation times, highlights the superior efficiency of our proposed method. These findings underscore the potential utility of the ‘‘Sample Gradient Descent’’ technique across diverse domains, ranging from machine learning to optimization problems. The significant improvements in convergence rates and computation times make our algorithm particularly appealing to practitioners and researchers seeking enhanced efficiency in gradient descent optimization.
Sex estimation using angular measurements of nasion, sella, and glabella on lateral cephalogram among Indonesian adults in Yogyakarta
Authors: Ningtyas Aini Hasibah , Widyaningrum Rini , Shantiningsih Rurie Ratna , Yanuaryska Ryna Dwi
Published: October 2023

Background

Sex estimation gives the probability that someone is classified as a male or a female. Lateral cephalogram analysis can be used for sex estimation due to the resistance and dimorphism of the skull. Glabella has been known to have dimorphic characteristic in male and female, while nasion and sella have been widely used as a standard point in many craniometric measurements. This study aimed to develop an equation using nasion–sella–glabella (NSG), sella–glabella–nasion (SGN), and glabella–nasion–sella (GNS) angles on lateral cephalograms for sex estimation among Indonesian adults in Yogyakarta, Indonesia.

Results

A total of 138 adults (aged 20–40 years) digital lateral cephalograms were taken from the dental records at Universitas Gadjah Mada Dental Hospital (108 used to form the equation of sex estimation; 30 used to test the equation), and the parameters were measured with EzDent-i Vatech. An independent t-test was used to analyze the differences in the angles between male and female adults. The equation for sex estimation was determined using discriminant function analysis. The average measurements of the NSG angles in male and female adults were 9.64° ± 1.36° and 11.21° ± 1.57°, respectively, the SGN angles were 54.65° ± 4.19° and 60.83° ± 4.13°, respectively, whereas the GNS angles were 118.33° ± 4.61° and 109.84° ± 5.19°, respectively. The independent t-test revealed a significant difference (p < 0.05) between male and female adults. Discriminant function analysis yielded an equation for sex estimation using the NSG, SGN, and GNS angles with an accuracy of up to 75.9%, with the accuracy of sex estimation based on the testing sample being 70%.

Conclusion

Based on the findings of this study, male Indonesian adults have a smaller NSG and SGN angles but a bigger GNS angle than female adults. Related to the accuracy, the study’s findings indicate that the discriminant function of NSG, SGN, and GNS angles for sex estimation should not be generalized in wider population. More cephalogram parameters must be investigated in future studies on sex estimation.
Assess: anomaly sensitive state estimation with streaming systems
Authors: Brand Michael , Engel Dominik , Lehnhoff Sebastian
Published: October 2023

Information and communication technology (ICT) is an increasing part of modern power systems, which are, therefore, recognised as cyber-physical energy system (CPESs). The increase of ICT affects the situational awareness in CPESs, which is traditionally solely based on information about the power system but not about the ICT system. However, CPESs are facing various challenges regarding the integrity, correctness, and availability of process data due to the interconnection with ICT. Examples are stealthy false data injection attack (FDIAs). This paper pursues a holistic approach to describe the quality of process data, which brings together aspects like integrity, correctness, and availability in multivariate trust values. The arising research question this paper deals with is, how multivariate trust in physical measurements in a CPES can be modelled, estimated, and integrated into situational awareness. A proposed framework implements a context-sensitive and multivariate trust model as well as a trust sensitive state estimation. While these two artefacts are already published, the focus of this paper is on the implementation of the framework and the fulfilment of the requirements for timeliness, interoperability, flexibility, and scalability. It is evaluated in three different scenarios with CIGRE and IEEE benchmark grids.
Verifiable proofs for the energy supply chain: small proofs brings you a long way
Authors: Jokumsen Morten , Pedersen Torben Pryds , Daugaard Martin Schmidt , Tschudi Daniel , Madsen Mikkel Wienberg , Wisbech Thomas
Published: October 2023

We describe a solution for secure and verifiable handling of energy certificates. Such certificates are increasingly used to claim and prove responsible use of green energy, and there is a strong need for transparency and public verifiability. While the proposed solution is designed for handling electricity it applies to different types of energy as well and the concepts may also be applied to other domains. Transmission System Operators are trusted to record consumption and production of electricity. The movement from volume-based MWh yearly certificates to spot-market aligned hourly or 15 min time-volume based intervals, creates challenges in relation to handling large amounts of data and subsequent transactions. Small discrete intervals gives the certification increased accuracy of energy consumption, as a means to prevent greenwashing, with the cost of higher amounts of transactional data and complexity. To ensure trust in the certification, these certificates must in addition be unique and publicly verifiable. This paper describes how blockchain technology can be used to create the required transparency and public verifiability. We show how large amounts of data can be efficiently handled on blockchains and how confidential data such as the amount of used energy in the certificates can be protected, ensuring privacy and correctness of the certificates.
Effect of thermocycling on acetal resin versus PEEK surface hardness and flexure strength of implant-retained overdenture bars: in vitro study
Authors: Salem Sherihan Hanafy , AlSourori Ali Abdulghani , Mostafa Marwa Hassan
Published: October 2023

Background

Implant-supported mandibular overdentures with bar attachments are considered an excellent option for a completely edentulous mandible. It provides a long-lasting and reliable solution to restore function and aesthetics to the patient. Many materials can be used for the construction of bar attachments, among which are PEEK and Acetal resin materials. The choice between PEEK and Acetal bar attachments eventually depends on the application, considering factors such as load-bearing requirements, biocompatibility, adaptability, and ease of use.

Methods

Twelve 3D-printed edentulous mandible models each received two implants. Models were then divided into two equal groups. Group1: Six models with PEEK bars were fabricated by thermo-pressed technique while Group 2: Six models with Acetal resin bars were fabricated by thermo-pressed technique. Surface hardness and flexure strength were then evaluated and statistically analyzed before and after thermocycling.

Results

PEEK group revealed significant higher surface hardness than Acetal resin before and after thermocycling. Regarding flexure strength, PEEK showed an insignificant increase than Acetal before thermocycling; however, the PEEK group displayed much higher values than the Acetal group following the thermocycling, resulting in a significant difference between the two groups.

Conclusions

Bar made of PEEK showed more promising surface hardness and flexure strength than Acetal resin bar.
Correlation between speed and agility with an influence of gender in adolescent Kho-Kho players—an observational study
Authors: Mahapatra Charuhasini , Abhinandan Abhishek
Published: October 2023

Background

Adolescent girls who participate in sports have injuries 4–6 times greater as compared to boys. Several factors are responsible for the injuries are as anatomical, biomechanical, hormonal, and some extrinsic factors. The ideal level of motor characteristics, including speed, endurance, agility, and flexibility, determines how well a player performs in Kho-Kho. Speed and agility are two major components for better Kho-Kho performance. This study aimed to evaluate the correlation between speed and agility with an influence on gender in Kho-Kho players.

Method

A total of 75 participants (boys 34 and girls 41) Kho-Kho players in the age groups 11–17 years were included in the study based on selection criteria. For the agility-modified T test for speed, a 50-m Dash test was done.

Results

Pearson’s correlation was used to analyze the collected data. The results indicated a moderate correlation between agility and speed in both genders (r = 0.404, p = 0.001), but in boys specifically, it showed a moderate correlation(r = 0.586, p = 0.001) and in girls, it showed a weak correlation (r = 0.267, p = 0.095).

Conclusion

It can be concluded from the results of this study that there is a moderate correlation between speed and agility in Kho-Kho players, but boys have a moderate and girls have a weak correlation this indicates combining both genders and a particular gender also shows a weak to moderate correlation between speed and agility in adolescent Kho-Kho players.
Activation and induction of antigen-specific T follicular helper cells play a critical role in recombinant SARS-CoV-2 RBD vaccine-induced humoral responses
Authors: Yang Songhao , Duan Liangwei , Wang Chan , Zhang Cuiying , Hou Siyu , Wang Hao , Song Jiahui , Zhang Tingting , Li Zihua , Wang Mingxia , Tang Jing , Zheng Qianqian , Wang Hui , Wang Qi , Zhao Wei
Published: October 2023

The role of follicular T helper (Tfh) cells in humoral response has been considered essential in recent years. Understanding how Tfh cells control complex humoral immunity is critical to developing strategies to improve the efficacy of vaccines against SARS-CoV-2 and other emerging pathogens. However, the immunologic mechanism of Tfh cells in SARS-CoV-2 receptor binding domain (RBD) vaccine strategy is limited. In this study, we expressed and purified recombinant SARS-CoV-2 RBD protein in Drosophila S2 cells for the first time and explored the mechanism of Tfh cells induced by RBD vaccine in humoral immune response. We mapped the dynamic of Tfh cell in lymph node and spleen following RBD vaccination and revealed the relationship between Tfh cells and humoral immune response induced by SARS-CoV-2 RBD vaccine through correlation analysis, blocking of IL-21 signaling pathway, and co-culture of Tfh with memory B cells. Recombinant RBD protein elicited a predominant Tfh1 and Tfh1-17 subset response and strong GC responses in spleen and lymph nodes, especially to enhanced vaccination. IL-21 secreted by Tfh cells affected the development and differentiation of B cells and played a key role in the humoral immune response. These observations will help us further understand the mechanism of protective immune response induced by COVID-19 vaccine and has guiding significance for the development of vaccines against newly emerging mutants.
Evidence-Based Care of Older Adults With Metastatic Colorectal Cancer: Insights From Landmark Clinical Trials
Authors: Ioffe Dina , Dotan Efrat
Published: October 2023

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology , to patients seen in their own clinical practice.

Colorectal cancer (CRC) is the second leading cause of cancer-related death in the United States with more than half of the patients diagnosed being older than 65 years, and an expected further increase in older adults (OA) diagnosed with this cancer in the coming years as the population ages. Prospective data guiding the management of older patients with metastatic CRC (mCRC) have been limited and treatment decisions for these patients are often guided by chronologic age, crude evaluation of performance status, and extrapolation from trials conducted in younger individuals. Recent evidence from randomized clinical trials specifically designed for OA supports treatment deintensification and dose modification to increase tolerability without compromising efficacy in older, frailer patients with mCRC. Additional studies support the incorporation of geriatric assessment (GA)–driven care to further improve the outcomes of OA with mCRC. Although the use of GA has not been validated in guiding specific treatment selection or modification for OA with mCRC, it provides a comprehensive and objective evaluation of a patient's functional status, comorbidities, risk of potential toxicities, effect on the quality of life, goals of care, and assists with personalizing therapy. With the increase in the number of OA we care for in our practices, it is time to stop extrapolating and define an evidence-based approach for this population that is based on data from prospective elderly specific clinical trials.
A De Novo Deleterious PHEX Variant Without Clinical Features of X-Linked Hypophosphatemia
Authors: Kayser Michelle , Jain Preti , Bale Allen , Carpenter Thomas O
Published: October 2023

X-linked hypophosphatemia (XLH), the most common form of hereditary rickets, is due to inactivation of PHEX, resulting in increased circulating fibroblast growth factor 23. Consequent renal phosphate loss leads to hypophosphatemia, rickets, and progressive bow deformity. Inheritance is X-linked dominant, such that heterozygous females are affected, as well as hemizygous males. A 10-month-old girl was referred for potential treatment for presumed XLH. Amniocentesis, performed following prenatal identification of duodenal atresia, polyhydramnios, and intrauterine growth restriction, revealed a de novo X-chromosomal deletion encompassing 10 genes, including PHEX. Postnatal genetic testing confirmed presence of the deletion in the baby. She demonstrated no phenotypic, biochemical, or radiographic features of XLH. Neither parent had features of XLH, nor carried the deletion. Given the discordance between genotype and phenotype, evaluation for skewed X-inactivation was pursued. Methylation analysis via the androgen receptor locus was inconclusive, thus RNA sequencing was pursued. Analysis of 12 high-quality single nucleotide polymorphisms (SNPs) that are expressed in mRNA revealed skewed X-inactivation. Heterozygous disruption of PHEX typically confers a diagnosis of XLH. Skewed X-inactivation, whereby one X chromosome is preferentially silenced, appears to have protected this patient from the expected expression of an X-linked dominant disorder.
Atuação de psicólogas/os com Redução de Danos: a construção de uma apologia ao cuidado.
Authors: Silva Carlos Diogo Mendonca da , Brasilino Queiroz Pinto Martins Arthur , Dantas de Vasconcelos Leticia , De Maria Quirino Lopes Samara , Gonçalves Domingos Maria Sâmira , Rocha Sombra Afonso José
Published: October 2023

Compreende-se que o uso de drogas é uma prática que vai muito além do bem ou do mal, estando atravessada por fatores contextuais, individuais, da realidade do sujeito, entre outros. Ao longo da história, a relação dos sujeitos com essas substâncias passou por diferentes mudanças. Buscou-se, neste ensaio, refletir sobre as implicações para a prática profissional de psicólogas e psicólogos no campo da saúde mental, em especial, no cuidado com aqueles que trazem questões relacionadas ao uso abusivo de álcool e outras drogas. Conclui-se, a partir do estudo realizado, a necessidade de superar determinada visão individualista e descontextualizada sobre os modos de constituição da subjetividade, que, muitas vezes, leva a toda uma culpabilização do indivíduo por um sofrimento oriundo de questões coletivas.
Αξιοποιώντας την Αφηγηματική Συμβουλευτική Σταδιοδρομίας για την Ενίσχυση της Βιώσιμης Επαγγελματικής Ανάπτυξης στην Τριτοβάθμια Εκπαίδευση
Authors: Αργυροπούλου Κατερίνα
Published: October 2023

Oι θεωρητικές προσεγγίσεις της αφηγηματικής συμβουλευτικής για τη σταδιοδρομία έχουν επηρεαστεί από το κίνημα του κονστρουκτιβισμού και βρίσκονται, όπως και η επαγγελματική ζωή, σε συνεχή εξέλιξη. Σύμφωνα με τις προσεγγίσεις αυτές η επαγγελματική πορεία των ατόμων είναι αποτέλεσμα της «κατασκευής» που αυτά κάνουν, ανάλογα με το πώς νοηματοδοτούν την πραγματικότητα που τα περιβάλλει. Παράλληλα, η βιωσιμότητα στη σταδιοδρομία σηματοδοτεί τη δυναμική αλληλεπίδραση του ατόμου με το περιβάλλον με τέτοιο τρόπο, ώστε το άτομο να αυτορυθμίζεται και να εξελίσσεται. Έτσι, η παρούσα έρευνα επιχειρεί να διερευνήσει την επαγγελματική ιστορία μεταπτυχιακών φοιτητών/τριών σε σχέση με τη βιώσιμη επαγγελματική τους ανάπτυξη και την πραγματοποίηση στόχων με κοινωνικό περιεχόμενο. Οι συμμετέχοντες της έρευνας ήταν 26 μεταπτυχιακοί φοιτητές και φοιτήτριες που παρακολουθούν μεταπτυχιακό πρόγραμμα σπουδών στη συμβουλευτική και τον επαγγελματικό προσανατολισμό. Για την ανάλυση των δεδομένων αξιοποιήθηκε η θεματική ανάλυση περιεχομένου προκειμένου να αναδυθούν επιμέρους θεματικές κατηγορίες, θέματα και υποθέματα, όπως επίσης και οι σχέσεις που αναπτύσσονται μεταξύ τους. Τα αποτελέσματα καταδεικνύουν ότι το αφηγηματικό εργαλείο «Η Επαγγελματική Μου Ιστορία» τους βοήθησε να σχεδιάσουν τα επόμενα εκπαιδευτικά και επαγγελματικά τους βήματα, ενώ συνετέλεσε στην ανάπτυξη βιώσιμων σχεδίων για το μέλλον και την απόδοση νοήματος και σκοπού στο ρόλο της επαγγελματικής τους δραστηριότητας, με τη συνειδητοποίηση του αντίκτυπού της στους ίδιους και το κοινωνικό σύνολο.
Seven ascidian (Tunicata) species from the North Eastern Mediterranean
Authors: KARAHAN ARZU , TEMIZ BERIVAN , ÖZTÜRK ESRA , DOUEK JACOB , RINKEVICH BARUCH
Published: October 2023

Members of the tunicates, a subphylum of marine filter-feeder chordates, inhabit all marine and oceanic habitats from the subtidal to the abyssal. Considered the closest relatives to the vertebrates, the tunicates are widely used as model organisms for evo-devo, allorecognition, senescence, and whole-body regeneration studies. However, species boundaries are poorly understood due to the high morphological and genetic plasticity that characterizes many tunicate taxa. Here, we present findings on seven tunicate species (Botrylloides israeliense, Botrylloides sp., Botryllus humilis, Botryllus schlosseri, Symplegma brakenhielmi, Polyclinum constellatum and Didemnum perlucidum) sampled from six Turkish sites at the North Eastern Mediterranean Sea and employed the mitochondrial barcoding marker (COI) for evaluating the relationships among geographically restricted and widely spread ascidian species. Species delimitation was conducted using sequences generated in the current study in addition to sequences obtained from GenBank. General morphological features and colors of colonies were recorded at sampling sites. Then, all Styelidae colonies were attached and cultured on slides in an aquaculture room, enabling the study of other features, such as zooid distributions and sizes, oral tentacle  numbers, and life cycles, using stereo and light microscopes. The spicules of formalin-fixed Didemnum perlucidum samples were examined under a light microscope. Then, scientific names were assigned to all species based on the results of the species delimitation and on comparisons of the obtained COI sequences with GenBank sequences. A putative new Botrylloides species (Botrylloides sp.) from the Antalya region was revealed, with a 99% match with the COI gene of another specimen from Saudi Arabia; further waiting for detailed traditional taxonomy.
Perceived risk and condomless sex practice with commercial and non-commercial sexual partners of male migrant sex workers in London, UK
Authors: Ruiz-Burga Elisa
Published: October 2023

Background: Since the emergence of HIV and the AIDS pandemic, the majority of risk-reduction interventions have been centred on the use of condoms in sex workers.   Methods: This qualitative study recruited 25 male migrant sex workers in London to understand their risk perception and condomless sex experiences within the context of sex work and private life. The data was collected using face-to-face interviews, analysed using thematic analysis, and the findings interpreted through the theory of planned behaviour.   Results: The themes explain that condomless sex with clients occurred when participants consciously accepted to perform this service deploying a risk assessment of clients, faulty strategies, and sexual practices to reduce their risk; or when they lost control because of recreational drugs, feeling attraction to clients, were in precarious circumstances, or were victims of violence. Conversely, condomless sex with non-commercial partners occurred according to the type of relationship, with formal partners it was rationalised through emotional aspects attached to this kind of relationship, while with casual partners it was connected to sexual arousal and the use of alcohol and drugs.  Conclusions: Reinforce educational interventions to deliver STI-HIV information, enhance the use of condoms, and to address specific contextual factors that facilitate condomless practice with commercial and non-commercial sexual partners.
Amodiaquine drug pressure selects nonsynonymous mutations in pantothenate kinase 1, diacylglycerol kinase, and phosphatidylinositol-4 kinase in Plasmodium berghei ANKA
Authors: Chepngetich Jean , Muriithi Brenda , Gachie Beatrice , Thiong'o Kevin , Jepkorir Mercy , Gathirwa Jeremiah , Kimani Francis , Mwitari Peter , Kiboi Daniel
Published: October 2023

Background Lumefantrine (LM), piperaquine (PQ), and amodiaquine (AQ), the long-acting components of the artemisinin-based combination therapies (ACTs), are a cornerstone of malaria treatment in Africa. Studies have shown that PQ, AQ, and LM resistance may arise independently of predicted modes of action. Protein kinases have emerged as mediators of drug action and efficacy in malaria parasites; however, the link between top druggable Plasmodium kinases with LM, PQ, and AQ resistance remains unclear. Using LM, PQ, or AQ-resistant Plasmodium berghei parasites, we have evaluated the association of choline kinase (CK), pantothenate kinase 1 (PANK1), diacylglycerol kinase (DAGK), and phosphatidylinositol-4 kinase (PI4Kβ), and calcium-dependent protein kinase 1 (CDPK1) with LM, PQ, and AQ resistance in Plasmodium berghei ANKA. Methods We used in silico bioinformatics tools to identify ligand-binding motifs, active sites, and sequence conservation across the different parasites. We then used PCR and sequencing analysis to probe for single nucleotide polymorphisms (SNPs) within the predicted functional motifs in the CK, PANK1, DAGK, PI4Kβ, and CDPK1. Using qPCR analysis, we measured the mRNA amount of PANK1, DAGK, and PI4Kβ at trophozoites and schizonts stages. Results We reveal sequence conservation and unique ligand-binding motifs in the CK, PANK1, DAGK, PI4Kβ, and CDPK1 across malaria species. DAGK, PANK1, and PI4Kβ possessed nonsynonymous mutations; surprisingly, the mutations only occurred in the AQr parasites. PANK1 acquired Asn394His, while DAGK contained K270R and K292R mutations. PI4Kβ had Asp366Asn, Ser1367Arg, Tyr1394Asn and Asp1423Asn. We show downregulation of PANK1, DAGK, and PI4Kβ in the trophozoites but upregulation at the schizonts stages in the AQr parasites. Conclusions The selective acquisition of the mutations and the differential gene expression in AQ-resistant parasites may signify proteins under AQ pressure. The role of the mutations in the resistant parasites and their impact on drug responses require investigations using reverse genetics techniques in malaria parasites.
Dynamic Pricing with External Information and Inventory Constraint
Authors: Li Xiaocheng , Zheng Zeyu
Published: October 2023

A merchant dynamically sets prices in each time period when selling a product over a finite time horizon with a given initial inventory. The merchant utilizes new external information that is observed at the beginning of each time period, whereas the demand function—how the external information and the price jointly impact that single-period demand distribution—is unknown. The merchant’s decision, setting price dynamically, serves dual roles to learn the unknown demand function and to balance inventory with an ultimate objective to maximize the expected cumulative revenue. The main objective of this work is to characterize and provide a full spectrum of relations between the order of optimal expected cumulative revenue achieved in three decision-making regimes: the merchant’s online decision-making regime, a clairvoyant regime with complete knowledge about the demand function, and a deterministic regime in which all the uncertainties are relaxed to the expectations. In the analyses, we derive an unconstrained representation of the optimality gap for generic constrained online learning problems, which renders tractable lower and upper bounds for the expected revenue achieved by dynamic pricing algorithms between different regimes. This analytical framework also inspires the design of two dual-based dynamic pricing algorithms for the clairvoyant and online regimes.

This paper was accepted by Hamid Nazerzadeh, data science.

Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2023.4963 .
O Infilmável e as adaptações de Dom Quixote
Authors: Loureiro Junior João Pereira , Loureiro Junior João Pereira , Sarmento-Pantoja Augusto
Published: October 2023

De todas as narrativas memoráveis que conhecemos ao longo da história humana, Dom Quixote é de longe, uma das mais traduzidas para o cinema. São aproximadamente 60 adaptações. No presente trabalho apresentamos um levantamento estatístico acerca das obras adaptadas em torno de Dom Quixote, para em seguida analisarmos algumas delas sob o prisma da tradução cinematográfica, considerando para isso uma discussão em torno do Infilmável, uma categoria que se ergue como proposta para entender os mecanismos de negação e impossibilidade que se coloca no âmbito da tradução de obras literárias para o cinema/TV. Um dos objetivos pontuais deste trabalho é entender as versões da obra a partir da essência que a faz eterna: o poder atemporal da linguagem que Dom Quixote impôs ao nosso imaginário. Para teorizar em torno do tema, utilizamos para esta pesquisa alguns autores como Sánchez Noriega 2001; León (2015); Hildalgo e Arruda (2020); Stam (2008); Morell (2022) Silva (2016); Johnson (2003); Dias (2014).
Do Livro ao LP: crônica de costumes e referências intermidiáticas em Quarto de despejo – Carolina Maria de Jesus cantando suas composições
Authors: Loyolla Dirlenvalder do Nascimento , Ferreira Cinara Antunes
Published: October 2023

Neste estudo efetivamos uma análise de canções do LP Quarto de despejo – Carolina Maria de Jesus cantando suas composições, sob a perspectiva da teoria da intermidialidade. Buscamos investigar, especificamente, o modo através do qual esse disco lançado em 1961 pode ser visto como uma obra duplamente marcada pela referência intermidiática, uma vez que, para além da relação direta com o título do livro Quarto de despejo – diário de uma favelada, publicado em 1960 por Carolina Maria de Jesus, suas canções comportam-se como crônicas de costumes tendo como parâmetro o espaço social no qual vivia a escritora. Os títulos das doze composições que integram o disco são: "Rá, ré, ri, ró, rua", "Vedete da favela", "Pinguço", "Acende o fogo", "O pobre e o rico", "Simplício", "O malandro", "Moamba", "As granfinas", "Macumba", "Quem assim me ver cantando" e "A Maria veio?". Pautado em pesquisa bibliográfica, análise de narrativa e de canções, este trabalho conta com o seguinte quadro teórico: Arrigucci Jr. (1987), Cunha (in: CHALHOUB; NEVES; PEREIRA, 2005), Melo (in: CASTRO; GALENO, 2005), Miranda (2013), Oliveira (2010), Rajewsky (in: DINIZ, 2012; in; DINIZ; VIEIRA, 2012) e Ramazzina Ghirardi, Rajewsky e Diniz (2020).
Transmidialidade e reescrita criativa em Algo antigo, de Arnaldo Antunes
Authors: Kobs Verônica Daniel
Published: October 2023

Este artigo objetiva analisar a obra Algo antigo, de Arnaldo Antunes, focalizando especificamente a transmidialidade e a expansão da literatura nas mídias digitais. Para isso, serão avaliados dois formatos distintos: o livro impresso, lançado em 2021; e os vídeos on-line publicados pelo próprio artista, em 2022, no YouTube. Como pressupostos teóricos, foram utilizados principalmente os estudos de Henry Jenkins, Lars Elleström, Giselle Beiguelman e Roxane Rojo. Considerando a reconfiguração do livro físico e a preponderância do computador e da Internet nos dias atuais, os resultados obtidos neste estudo demonstram que a transmidialidade privilegia os aspectos múltiplo, híbrido e interativo, em conformidade com os conceitos de hipermídia, multimodalidade e transletramento. Diante disso, foi possível constatar que o processo transmidiático gera um ciclo de reciprocidade, protagonizado pelas diferentes mídias envolvidas no projeto, sem, no entanto, restringir-se à mera repetição. Portanto, a obra precisa ser recriada, possibilitando alterações significativas no que diz repeito à autoria e à leitura, de modo a oferecer ao público novas perspectivas de forma e conteúdo.
Representações intermidiáticas da violência de gênero em Patrícia Melo e Luiza Romão
Authors: AMANCIO Angélica
Published: October 2023

Resumo: O presente trabalho tem por objetivo examinar as obras de duas artistas multimídia brasileiras: Patrícia Melo e Luiza Romão. Após uma apresentação panorâmica dos trabalhos das autoras, nos quais identificam-se práticas associadas à intermidialidade e à literatura expandida, detemo-nos na análise de dois volumes, em especial: o romance Valsa Negra (2003), de Melo, e o livro de poemas Sangria (2017), de Romão. Espera-se demonstrar em que medida a extrapolação de recursos narrativos e poéticos tradicionais, pelo empréstimo e o entrecruzamento de mídias, potencializa a crítica política de viés feminista vislumbrável nessas publicações. A análise fundamenta-se em teóricos como Irina Rajewsky e Werner Wolf, para os estudos da intermidialidade; Vera Follain de Figueiredo e Alex Martoni, para o conceito de “literatura expandida”; Silviano Santiago, para se pensar cultura de massa; Ursula Le Guin, por uma reflexão sobre o patriarcalismo na literatura; Aníbal Quijano, para considerações relativas à colonialidade, entre outros autores.
Los factores sociales en el acceso a las prestaciones y servicios del catálogo de servicios del Sistema para la Autonomía y Atención a la Dependencia de la Ley 39/2006, de 14 de diciembre, de Promoción de Autonomía Personal y Atención a las Personas en Situación de Dependencia.
Authors: Novillo García Belén , Cubero García Marta
Published: October 2023

En el presente artículo, se analiza la necesidad de contemplar los factores sociales en el acceso a las prestaciones y servicios del Catálogo de Servicios del Sistema para la Autonomía y Atención a la Dependencia de la Ley 39/2006, de 14 de diciembre, de Promoción de Autonomía Personal y Atención a las personas en situación de dependencia. Se pone de manifiesto, que, tanto a la hora de determinar el orden de prelación de dichos servicios y prestaciones como a la hora de acordar la intensidad de estos, se deben contemplar también los factores sociales que afectan a la vida de las personas que se encuentran en situación de dependencia a fin de mejorar su calidad de vida de manera integral.
Gestión psicosocial y sanitaria de la covid-19 en un centro de menores de edad con necesidades específicas de apoyo: del confinamiento al proceso de vacunación
Authors: González Herrera Inmaculada
Published: October 2023

El 11 de marzo de 2020 la Organización Mundial de la Salud (OMS) declaró la COVID-19 "pandemia in-ternacional" y los centros dedicados al cuidado de personas vulnerables tuvieron que adaptarse rápi-damente a esta nueva situación. El presente artículo pretende aglutinar las medi-das puestas en marcha en el Centro de Acogida de Menores (CAM) Xiquets que han permitido generar un protocolo de actuación sistematizado que puede servir para otros centros de similares características y para el propio recurso. El método de trabajo de CAM Xiquets se basa en dos pilares: el modelo de la calidad de vida y el de la atención integral centrada en la persona. A esta metodología se le ha sumado la ingente normativa que sobre la COVID-19 ha ido surgiendo desde organismos internacionales, nacionales y autonómicos. Sin embargo, a mediados de enero y principios de febrero de 2021 el recurso ha tenido dos brotes, por lo que este trabajo también pretende ahondar en las dificultades de tratar este tipo de pandemias en un centro dedicado a la atención a la infancia y adolescencia con necesi-dades de apoyo. La vacunación es también un aspec-to que cabría mejorar por parte de todos/as.
Olaudah Equiano and Freedom of the Scenes: Embodied Performances in Equiano's Interesting Narrative
Authors: Okoli Chinaza Amaeze
Published: October 2023

Abstract: This article considers Equiano's turn to performance and spectacle in his Interesting Narrative of the Life of Olaudah Equiano in relation to the eighteenth-century stage practice known as "freedom of the scenes." Widely regarded as the "prototype" of all subsequent slave narratives, the Narrative is infused with instances of racial mimicry, including whiteface and blackface, as well as self-fashioning through dress and style—scenes that evince potential for understanding Equiano's more radical abolitionist vision. In foregrounding race and mimicry, Equiano not only takes on the techniques of what was emerging in his lifetime as "blackface," but he reverses the dynamic, appropriating "whiteness" in whiteface acts in order to offer a sustained critique of racial injustice. By strategically positioning himself before audiences through mimicry, fashion and style, Equiano demonstrates how performance cultures help Black Atlantic subjects to constitute themselves as a people.
Circumcision Stories: Enhancing our Understanding of Parental Perspectives in a Context of Controversy
Authors: Carpenter Laura M.
Published: October 2023

Abstract: This commentary examines twelve stories in which parents recount how they (and often their co-parent) decided whether or not to circumcise their newborn sons. Several debated whether this should be their decision to make. The stories offer an intimate glimpse into people's efforts to do the best for children in a context of incomplete and changing information and intense public controversy. The commentary explores the diverse meanings and contradictory commonsense beliefs that surround foreskin removal in the United States today. Considering these parents' reflections—and their silences—can help us appreciate the real-life consequences of debates about the ethics of male circumcision.
What Do We Owe to Patients Who Leave Against Medical Advice? The Ethics of AMA Discharges
Authors: Hendizadeh Leenoy , Goodman-Crews Paula , Martin Jeannette , Weber Eli
Published: October 2023

Abstract: Discharges against medical advice (AMA) make up a significant number of hospital discharges in the United States, and often involve vulnerable patients who struggle to obtain adequate medical care. Unfortunately, much of the AMA discharge process focuses on absolving the medical center of liability for what happens to these patients once they leave the acute setting. Comparatively little attention is paid to the ethical obligations of the medical team once an informed decision to leave the acute care setting AMA has been made. Via a case narrative, we offer an ethical framework that we believe can help guide an ethically defensible AMA discharge process. By emphasizing our duty to provide the best care possible under the circumstances, we contend, our ethical obligations to promote the patient's best interests can still be met despite their decision to leave the acute setting against medical advice.
Childhood, Redemption, and l'écriture de soi : Colette's La chambre éclairée and La maison de Claudine
Authors: Cummins Laurel
Published: October 2023

Abstract: This article examines the child figure in Colette's work, analyzed as a means to a literary redemption after Colette's initiation into literature through another work depicting a child, Claudine à l'école . The reintegration of the child figure is presaged by the appearance in early works, especially La vagabonde , of images of the archetypal "divine" child. The child figure is then integrated into stories, first featuring Colette's daughter Bel-Gazou, then the child Colette herself. The theme of play, traced in vignettes from La chambre éclairée and La maison de Claudine , reveals a process by which Colette reintegrates the child figure into her textual self. This then participates in giving voice to Colette's écriture de soi .