bluuebunny/crossref_metadata_2025 huggingface dataset:
PEMBEBANAN JAMINAN ATAS BENDA BENDA TIDAK BERGERAK DALAM KONTRAK PEMBIAYAAN MUDHARABAHPERSPEKTIF UNDANG-UNDANG NOMOR 4 TAHUN 1996 TENTANG HAK TANGGUNGAN
Authors: Harahap Muhammad Yadi
Published: June 2020

The imposition of collateral for immovable objects, especially land in mudharabah financing contracts, is preceded by making a guarantee contract to the capital owners. The purpose is to fulfil the implementation of obligation payment, even though there must not be collateral in mudharabah financing contract. Therefore, the guarantee of liability means that the collateral at any time can be confiscated and sold by the capital owner to repay the obligation. This study aims to find a comprehensive solution about how and what is the purpose of imposing collateral for immovable objects which are originally not part of mudharabah financing contracts principles. Empirical juridical research method is employed where law is not only considered as law in books but also in action with legal regulation approach, namely the 1996 Law Number 4 concerning Mortgage Rights. The results indicate that the collateral imposition for immovable objects in mudharabah financing contract refers to the aforementioned law concerning mortgage rights which aims at applying the precautionary and risk principles based on the 2008 Law Number 21 concerning Sharia Banking.

Pembebanan jaminan atas benda-benda tidak bergerak khususnya tanah dalam kontrak pembiayaan mudharabahlebih dahulu dilakukan kontrak pemberian jaminan kepada pemilik modal dengan tujuan untuk pemenuhanpelaksanaan pembayaran kewajiban, sekalipun pada prinsipnya dalam kontrak pembiayaan mudharabah tidak dibenarkan ada jaminan.Untuk itu pembebanan jaminan hak tanggungan dengan sendirinya telah meletakkan kebendaannya di mana setiap saat dapat disita dan dijual oleh pemilik modal untuk mengembalikan pelunasan kewajiban dalam kontrak pembiayaan mudharabah.Penelitian ini bertujuan untuk mencari solusi secara komprehensif tentang bagaimana dan apa tujuan dilakukan pembebanan jaminan atas benda tidak bergerak dalam kontrak pembiayaan mudharabahyang pada prinsipnya tidak dibenarkan. Untuk menjawab pertanyaan penelitian tersebut metode yang digunakan adalah metode penelitian yuridis empiris di mana hukum tidak hanya dilihat sebagai law in books tetapi juga law in action dengan pendekatan peraturan perundang-undangan yaitu UU No. 4 Tahun 1996 Tentang Hak Tanggungan. Hasil penelitian menunjukkan bahwa pembebanan jaminan atas benda-benda tidak bergerak dalam kontrak pembiayaan mudharabah mengacu kepada UU No. 4 Tahun 1996 tentang hak tanggungan, dengan tujuan untuk menerapkan prinsip kehati-hatian dan prinsip risiko sesuai dengan amanat Undang-undang No. 21 Tahun 2008 Tentang Perbankan Syariah.
KEABSAHAN AKTA RISALAH LELANG SEBAGAI AKTA OTENTIK DALAM PELAKSANAAN LELANG ELEKTRONIK OLEH KANTOR PELAYANAN KEKAYAAN NEGARA DAN LELANG
Authors: KARINA AHNIA SEPTYA , Sukarmi Sukarmi , Kawuryan Endang Sri
Published: June 2020

Currently, auction can be done through internet media a.k.a. e-auction. E-auction sells the goods by offering written prices without the presence of participants conducted through an internet-based auction application. This internet-based auction is similar with conventional one. The difference is in case of face-to-face which will affect the originality of Auction Treatise. Treatise is the official report of auction issued by Auction Officer. This paper aims at analyzing the validity of treatise as an authentic document in e-auction. This is a normative juridical writing by analyzing the validity of e-auction treatise reviewed with legislation related to internet-based auction. The results indicate that the treatise in e-auction is authentic since it follows the principles written in Article 1868 of the Civil Code. However, in PMK Number 90/PMK.06/2016 and Vendu Reglement concerning the recitation of the chief of Auction Treatise can be done using Lex Specialis Derogat Legi Generalis principles. The e-auction treatise also has valid proof as long as there is no lawsuit filing.

Saat ini, lelang dapat dilakukan melalui media internet atau e-auction. E-auction adalah penjualan barang dengan penawaran harga secara tertulis tanpa kehadiran peserta lelang yang dilakukan melalui aplikasi lelang berbasis internet. Lelang berbasis internet ini sama seperti pelaksanaan lelang konvensional. Perbedaanya terletak dalam hal tatap muka yang nantinya akan berpengaruh terhadap keotentikan Risalah Lelang. Risalah Lelang adalah berita acara
pelaksanaan lelang yang dibuat oleh Pejabat Lelang. Makalah ini mеngаnаlіsis kеаbsаhаn аktа Rіsаlаh Lеlаng sеbаgаі аktа оtеntіk dаlаm pеlаksаnааn lеlаng еlеktrоnіk. Penulisan ini adalah yuridis normatif dengan menganalisis keabsahan Risalah Lelnag elektronik yang dikaji dengan peraturan perundang-undangan yang berkaitan dengan lelang melalui internet. Hasil menunjukkan bahwa Risalah Lelang dalam lelang internet merupakan akta otentik karena telah memenuhi unsur-unsur dalam Pasal 1868 KUH Perdata. Namun dalam PMK Nomor 90/PMK.06/2016 dan Vendu Reglement tentang pembacaan Kepala Risalah Lelang tersebut dapat terselesaikan dengan asas Lex Specialis Derogat Legi Generalis. Risalah Lelang dalam lelang melalui media internet juga memiliki kekuatan pembuktian sempurna sepanjang tidak ada yang melakukan gugatan.
THE CONCEPT OF PROPERTY LAW EXTRACTED FROM THEMATIC VERSES OF AL-QUR’AN
Authors: Susamto Burhanuddin
Published: June 2020

Artikel ini menjelaskan hasil penggalian hukum tentang harta dari ayat-ayat al-Qur’an. Untuk mencapai tujuan tersebut, penulisan diawali dengan melakukan klasifikasi ayat-ayat al-Qur’ansecara tematik (maudlu’iyah);baik itu menggunakan lafadz al-mal secara langsung maupun lafadz lainnya yang berkaitan dengan harta. Ayat-ayat yang telah terkumpul kemudian akan digali menggunakan metode istinbath sehingga dapat diketahui hukum-hukum tentang harta. Keberadaan harta dari perspektif hukum al-Qur’an merupakan ujian Allah bagi manusia. Apabila ujian tersebut dapat dilalui dengan baik melalui ketaatan maka akan bernilai ibadah dari hasil pengamalan hukum-hukum harta baik yang bersifat perintah, larangan maupun kebolehan. Begitupula sebaliknya, kegagalan menghadapi ujian harta dapat menjerumuskan pemiliknya berbuat istidraj melalui kemaksiatan sehingga akan mendapatkan azhab Allah.

This study explains the results of extracting the law about property derived from the verses of al-Qur’an. To achieve this purpose, the writing is begun by classifying the verses inal-Qur’an thematically (maudlu’iyah); either using that term al-mal directly or other terms related to property. The collected versenthen will be analyzed using the method of istinbath, so the laws of propertyare discovered. Propertyfrom the perspective of al-Qur’an is God’s examination for humans. If they pass the examination properly through obedience, it will be worth the worship as a result of law practice in the form of instruction (al-amr), prohibition(al-nahy) or permissibility (al-ibahah). On the contrary, the failure in examinationcan trigger the owners to do istidraj by doing immoral acts that cause them to be punished (azab) by God.
Avishai Margalit — słownik pojęć podstawowych
Authors: Liszka Katarzyna
Published: June 2020

Celem artykułu jest przedstawienie głównych idei rozwijanych przez wybitnego izraelskiego myśliciela Avishaia Margalita. Odpowiada na potrzebę stworzenia propedeutyki lektury wynikającej z tego, że recepcja tego dzieła jest selektywna i podzielona według różnych dyscyplin, takich jak myśl polityczna, prawna, etyka, studia pamięciowe czy studia nad Zagładą, a Margalitowi nie poświęcono dotąd monografii systematyzującej całość jego dorobku. Artykuł stawia tezę, że najważniejszym założeniem tworzącym ramę myślenia społeczno-politycznego i moralnego Margalita jest rozróżnienie na etykę i moralność. Niniejszy artykuł ilustruje ten argument, wskazując powiązania między pojęciami, takimi jak przyzwoite społeczeństwo, upokorzenie, etyka i moralność pamięci, świadek moralny, zgniły kompromis czy zdrada. Oprócz treści dzieła Margalita artykuł podejmuje również zagadnienie metodologii, podkreślając znaczenie Wittgensteinowskiego pojęcia obrazu, filozofii przykładu oraz krytyki idolatrii/ideologii. Wybór głównych pojęć opisanych w artykule odsłania zarówno złożoność, jak i to, co spaja filozoficzną perspektywę rozwijaną w ciągu lat przez Margalita.
Notatki Załmena Gradowskiego w świetle koncepcji świadka moralnego Avishaia Margalita
Authors: Iwaszuk Marta
Published: June 2020

Celem artykułu jest zastosowanie koncepcji świadka moralnego sformułowanej przez Avishaia Margalita w książce The Ethics of Memory do analizy notatek sporządzonych przez Załmena Gradowskiego podczas jego pracy w Sonderkommando w Auschwitz-Birkenau. Aplikacja tej dość ogólnej, ale wyraźnie zarysowanej, koncepcji do konkretnego a jednocześnie trudnego świadectwa pozwoli z jednej strony doprecyzować istotne aspekty kontekstu, jaki kształtuje świadectwo moralne, z drugiej zaś wydzielić i przeanalizować w systematyczny sposób świadectwo moralne Z. Gradowskiego. Artykuł będzie również okazją do sformułowania uwag i pytań dotyczących koncepcji świadka moralnego, których zaadresowanie pozwoliłoby dookreślić paradygmatycznego świadka moralnego na bardziej szczegółowym poziomie, a tym samym zaproponować ustrukturyzowaną analizę niezwykle subtelnego fenomenu, jakim jest każde świadectwo moralne.
Türkiye’de zeytin (Olea europaea L.) üretimine uygun alanların coğrafi bilgi sistemleri (CBS) tabanlı çoklu kriter analizi ile belirlenmesi
Authors: TUĞAÇ Murat Güven , SEFER Filiz
Published: June 2020

Amaç: Bu çalışmada, Türkiye’de iklim, toprak ve topoğrafik faktörlere göre zeytin yetiştiriciliği için optimum yetişme koşulları ve potansiyel arazi uygunluk sınıfları belirlenmiştir.
Materyal ve Yöntem: Zeytin yetiştiriciliği için arazi uygunluğunun belirlenmesinde, Coğrafi Bilgi Sistemleri Tabanlı Çok Kriterli Karar Verme yöntemi uygulanmıştır. Bu kapsamda; yıllık ortalama sıcaklık, Ocak ayı mutlak minimum sıcaklık, Ocak ayı ortalama sıcaklık, Mayıs ayı ortalama sıcaklık, yaz dönemi ortalama maksimum sıcaklık, nem, yağış, arazi kullanım kabiliyeti sınıfları, toprak derinliği, kısıtlayıcı toprak özellikleri, erozyon, yükseklik ve eğim değerlendirme kriterleri olarak alınmış ve uygunluk sınır değerleri belirlenmiştir. Analitik Hiyerarşi Süreci yaklaşımı ile kriterlerin birbirlerine göre göreceli üstünlükleri belirlenerek kriter ağırlıklıları atanmış ve ürün uygunluk sınıfları oluşturulmuştur.
Araştırma Bulguları: Zeytin üretimi için Türkiye’nin % 6.7’si (5 254 937 ha) yetiştirmeye uygun alanları oluştururken, orta derecede uygun alanlar % 6.3 (4 940 932 ha). oranında yer almıştır. Zeytin üretimi yapılan uygun alanlarda; yıllık ortalama sıcaklık 16.8°C, mutlak minimum sıcaklık -2.8°C, Ocak ayı ortalama sıcaklık 7.0°C, Mayıs ayı ortalama sıcaklık 19.6°C ve yıllık toplam yağış 668 mm olarak belirlenmiştir.
Sonuç: Zeytin yetiştiriciliğinde bölgesel farklılıkların oluşmasında sıcaklık en önemli ve ağırlıklı faktördür. CBS tabanlı çok kriterli değerlendirme yöntemi, ürün uygunluk sınıflamasında etkin olarak kullanılmıştır.
Management of Pregnancy in 31-Year-Old Woman with Persistent Atrial Flutter After Cone Reconstruction for Ebstein’s Anomaly
Authors: Susilowati Eliana
Published: June 2020

There is a growing number of mothers suffering innate heart disease which could potentially risk their gestation period. Ebstein’s anomaly refers to a rare innate disease in the heart which accounts for less than 1% of most cases of innate heart disease, and only 5% of the patients surviving beyond 50 years of age. Cone reconstruction (CR) is an option for the repairment of tricuspid valve in patients with Ebstein anomaly. However, persistent arrhytmia, such as AFL, is possible to occur after CR. This case report aims to opt suitable pregnancy management of patients with persistent atrial flutter (AFL) after Cone reconstruction for Ebstein’s Anomaly. We report a 31 year-old woman who consulted for pregnancy planning due to history of Ebstein’s Anomaly, and had undergone successful cone reconstruction. No recorded history of AFL is reported. Physical examination finding was tricuspid regurgitation murmur without signs and symptoms of right ventricular failure. Electrocardiography showed counter-clockwise typical AFL. Echocardiography finding demonstrated post Cone reconstruction (CR), mild tricuspid regurgitation, and EF of 76%.
Son Dönem Osmanlı Eğitimci-Bürokratı Ahmed Kemal Paşa’nın Hayatı
Authors: BARDAK Musa
Published: June 2020

Bu çalışmanın amacı Osmanlı Devleti’nde Tanzimat ve Islahat dönemleri ile I. Meşrutiyet döneminde yaşamış eğitimci, sefir ve bürokrat Ahmet Kemal Paşa’nın (1808-1887) hayatı hakkında bilgi vermektir. Bu amaçla başta Osmanlı arşivi olmak üzere birçok arşiv ve kütüphane kataloğu taranarak elde edilen dokümanlar analiz edilmiştir. Paşa’nın eğitimci yönünün ön planda tutulduğu bu çalışma esnasında ulaşılan ve kronolojik olarak sıraya konulan verilerin bir kısmı, Ahmed Kemal Paşa hakkında önceden yazılmış kısa yazıların genişletilmiş ve düzeltilmiş halidir. Yetişme tarzından yaptığı görevlere, ailesinden kişisel özelliklere farklı yönlerinin ortaya konduğu çalışmada Türk eğitim sisteminin bugününü de etkileyen rolleriyle Paşa’nın profili etraflıca tasvir edilmiştir. Bu çalışmada ortaya konulanlar, Ahmed Kemal Paşa hakkında bilimsel ve kapsamlı bir biyografinin altyapısı olarak nitelendirilebilir.
Development of HOTS (High Order Thinking Skill) Oriented Learning Through Discovery Learning Model to Increase The Critical Thinking Skill of High School Students
Authors: Indah Purnama
Published: June 2020

The aim of this research is to produce HOTS (High Order Thinking Skill) lesson through a valid, practical, and effective discovery learning model for class XI high schools to improve students' critical thinking skills. This research is a development that refers to the Borg & Gall model. The subject trials for grade XI students of SMA Negeri 2 Sangatta Utara, East Kutai. Validity and practicality analysis techniques used percentage of descriptive techniques. The effectiveness analysis technique is by looking at the percentage of increase in students' pretest-posttest results. The result of this research in the form of development of learning tools which included: Syllabus, teaching materials, LKPD, and assessment instruments. The result showed that learning tools that have been developed meet the validity with a validity percentage of 99.66% which is categorized as very valid. The practicality of the lesson plan produced is very practical, this is indicated by the assessment of students as research respondents about 85.93%. HOTS (High Order Thinking Skill) lesson plan through Discovery Learning model to improve student’s critical thinking skills that are produced are able to provide the effectiveness learning, it looked through an increased in learning between pretest and posttest about 33%.Keywords: development, lesson plan, HOTS (high order thinking skill), discovery learning model, students' critical thinking skill
An Updated Primer on SARS-CoV-2 and the Evolving Covid-19 Pandemic
Authors: Mani Subramani
Published: June 2020

In this paper we first provide a primer on SARS-CoV-2 and Covid-19 delineating the etiopathogenesis, epidemiology, clinical manifestations and the natural history of the disease. We then trace the evolution of the Covid-19 pandemic highlighting the characteristics of the epidemic in China where the pandemic originated, select countries of Europe which peaked during April, and Brazil, US and India where the pandemic has taken serious turns recently. We also project some possible trajectories for the mega cities of India based on the demographic characteristics of these cities in comparison to New York city. This is an updated version of the article from mid-April published online.
Comparing Lung CT in COVID-19 Pneumonia and Acute Heart Failure: An Imaging Conundrum
Authors: Suciadi Leonardo Paskah , William Yonathan , Jorizal Patricia , Tarigan Vera Nevyta , Santoso Andreas Hartanto , Henrina Joshua , Tedjasukmana Firman , Marliani Kristanti Nathania
Published: June 2020

Background: Lung CT provides an effective modality to evaluate patients with suspected COVID-19. However, overlapping imaging findings with cardiogenic pulmonary oedema have been reported. Reports comparing lung CT features of these diseases have not been elaborated. Thus, we aimed to investigate these gaps in the knowledge regarding low-dose lung CT features of patients with COVID-19 pneumonia with those with acute heart failure (HF). Methods: This retrospective analysis enrolled hospitalized patients with COVID-19 (n=10) and acute heart failure (n=9) that exclusively underwent low-dose lung CT scans within 24-hours of admission. Clinical and lung CT characteristics were collected and analysed. Results: Ground-glass-opacities (GGO) appearance has been recorded in all subjects in HF and COVID-19 group. There was no significant statistical difference between the two groups for rounded morphology, consolidation, crazy paving pattern, lesion distribution, parenchymal band (P> 0.05). However, diffuse lesions were more frequent in HF cases (55.6% vs. 0%) than in COVID-19 pneumonia, which had predominantly multifocal pattern. Notably, CT images in HF patients were more likely to have signs of interstitial tissue thickening such as the interlobular septums, fissures and peribronchovascular interstitium (55.6% vs 0%, 88.9% vs 20% and 44.4% vs 0%,respectively), as well as cardiomegaly (77.8% vs 0%), increased artery to bronchus ratio (55.6% vs 0%), and pleural effusions (77.8% vs 0%). Conclusions: Major overlaps of lung CT imaging features existed between COVID-19 pneumonia and acute HF cases. However, signs of fluid redistribution are clues that favour HF over COVID-19 pneumonia.
Charge Conjugation Symmetry in the Finite Basis Approximation of the Dirac Equation
Authors: Salman Maen , Saue Trond
Published: June 2020

4-component relativistic atomic and molecular calculations are typically performed within the no-pair approximation where negative-energy solutions are discarded, hence the symmetry between electronic and positronic solutions is not considered. These states are however needed in QED calculations, where furthermore charge conjugation symmetry becomes an issue. In this work we shall discuss the realization of charge conjugation symmetry of the Dirac equation in a central field within the finite basis approximation. Three schemes for basis set construction are considered: restricted, inverse and dual kinetic balance. We find that charge conjugation symmetry can be realized within the restricted and inverse kinetic balance prescriptions, but only with a special form of basis functions that does not obey the right boundary conditions of the radial wavefunctions. The dual kinetic balance prescription is on the other hand compatible with charge conjugation symmetry without restricting the form of the radial basis functions. However, since charge conjugation relates solutions of opposite value of the quantum number κ, this requires the use of basis sets chosen according to total angular momentum j rather than orbital angular momentum ` . As a special case, we consider the free-particle Dirac equation, where the solutions of opposite sign of energy are related by charge conjugation symmetry. We note that there is additional symmetry in those solutions of the same value of κ come in pairs of opposite energy.
Respect of Skin Microbiome with Different Types of LeavE-on Skincare Products, an Ecobiological Approach
Authors: Callejon Sylvie , Giraud Félix , Larue Florence , Buisson Armonie , Matéos Léa , Grare Laurence , Guyoux Aurélie , Perrier Eric , Ardiet Nathalie , Trompezinski Sandra
Published: June 2020

Background: Skincare products are used daily to maintain a healthy skin (cleansing, moisturizing, protecting…), but their impact on this first layer, which corresponds to the skin microbiome, is still poorly understood. Preserving natural resources and mechanisms of the skin ecosystem is essential; an original approach based on these premises, called ecobiology, has recently emerged in skincare. Ecobiology considers the skin as an ever-evolving ecosystem which hosts human and microbial cells that interact together with their environment. In this context, we evaluated the impact on the skin microbiome of three types of leave-on face skincare products: a hydrophilic sterile solution, a micellar solution, and an oil-in-water emulsion. Materials and Methods: The individual microbial profiles of 20 Caucasian females were investigated. Samples were obtained twenty-four hours and four days following a daily application of the skincare products versus control area where no product was applied. To analyze the bacterial diversity and abundance of skin microbiome, a 16SrRNA gene sequencing was performed using the Illumina MiSeq platform. Results: Our results confirm the overall diversity of skin microbiome as previously observed and notably reveal the prevalence of Cutibacterium spp. and Staphylococcus spp. on sebaceous site (the back). Bacterial diversity and abundance were not affected by the products either twenty-four hours or four days after application, as indicated by comparison with the control. Moreover, no dissimilarity was observed between the three products versus their control, neither between each product. Conclusions: These preliminary results demonstrated for the first time that three different types of leave-on face skincare products such as a hydrophilic sterile solution, a micellar solution, and an emulsion have no impact on skin microbiome and can be considered as “microbiome friendly”.
Bentonite Exposure in Western Pacific Amyotrophic Lateral Sclerosis/ Parkinsonism Dementia Complex and Neurodegenerative Diseases
Authors: Reddy Kavitha
Published: June 2020

Neurodegenerative diseases of protein misfolding affect humans and animals. In humans, these diseases include Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Western Pacific amyotrophic lateral sclerosis and Parkinsonism-dementia complex (ALS/PDC). Mineral exposure may be important in the pathogenesis of protein misfolding cascades. The possible association of bentonite, montmorillonite, and mineral risk factors with Alzheimer’s disease, Parkinson’s disease, ALS, and Western Pacific ALS/PDC is analyzed and discussed.
Early and Contemporary Human Neuroimaging Studies of Serotonergic Psychedelics
Authors: Tagliazucchi Enzo
Published: June 2020

Serotonergic psychedelics are known to elicit changes in conscious awareness, including perception of the environment and the self, as well as in mood, emotion and different aspects of cognition (Nichols, 2016). The effect of these compounds is complex and resists a straightforward classification that is useful for other drugs, such as “stimulants” or “sedatives”. While the effects of certain psychedelics do have a stimulant dimension, their defining characteristic is the capacity to temporarily induce a state of altered consciousness. Because of this, the study of psychedelics cannot be based only on animal models, since humans are alone in their capacity to explicitly report the contents of their conscious awareness. Psychedelic research with healthy human subjects necessitates techniques for the non-invasive recording of brain activity or its physiological and metabolic correlates. These techniques are referred to as “neuroimaging”, and here we review their application in the study of the neural correlates of altered consciousness induced by serotonergic psychedelics.
Some Dirichlet Forms on Graphs as Traces of One-Dimensional Diffusions
Authors: Moussa Rafed
Published: June 2020

We compute explicitly trace of one-dimensional diffusion process which can be regarded as a Dirichlet form on graphs and we study its conservativeness property. Finally, we give an example of a discretization of one dimensional diffusion of Bessel's process with order $\nu$.
Multiplicative Error Modeling Approach for Time Series Forecasting
Authors: Chowdhury Poulami , Chakraborty Tanujit
Published: June 2020

Real-world time series data sets contain a combination of linear and nonlinear patterns, making the time series forecasting problem more challenging. In this paper, a new hybrid methodology is introduced for forecasting univariate time series data sets using a multiplicative error modeling approach. An autoregressive integrated moving average (ARIMA) model is combined with an autoregressive neural network (ARNN) for improving the predictions of individual forecast models. The proposed multiplicative ARIMA-ARNN model glorifies the chances of capturing the different combinations of linear and nonlinear patterns in time series. The model shows outstanding performance on six standard time-series data sets compared to other widely used single and hybrid forecasting models.
Getting critical thinking about ecosystem: How impact and responses of students about the CirGi learning model?
Authors: Harahap Lia Junita , Ristanto Rizhal Hendi , Komala Ratna
Published: June 2020

The broad scope of biology and the many sources of biology reading requires eleven grade students to think critically about sorting out information to develop and support students' critical thinking skills. CirGi is an integration of the cooperative integrated reading and composition (CIRC) learning model and guided inquiry (GI) that emphasizes reading and writing activities, accompanied by guidance from the teacher. This study aimed to analyze the influence of CirGi's learning model on students' critical thinking skills. This research uses a quasi-experiment method with pre-post control group design. The sampling technique used purposive sampling, namely 104 high school students. Data collection was carried out using instruments of critical thinking skills in the form of essays, questionnaire responses of students to learning, and observation sheets of syntax implementation. The data analysis technique used was one-way ANCOVA. After controlling for the pretest scores, the CirGi learning model's influence on students' critical thinking skills was influenced. This learning model was appropriate for learning biology, so it can regrow the activities of reading science books that impact students' critical thinking skills.
Refeeding Postmolting Method to Improve Weekly Production Performance of Rejected Laying Hens with Low Mortality
Authors: Airin Claude Mona , Hana Amelia , Astuti Pudji , Sarmin Sarmin , Susmiati Trini , Herawati Okti
Published: June 2020

This research aimed to investigate the influence of gradually feeding rejected laying hens after molting on the performance of production. This research used 6,000 rejected laying hens of 80 weeks old in Subur Farm. Molting method was a modification method by reducing the feed gradually. At the beginning of this research, the feed was given 120 g/laying hens/day and it would be reduced by 10 g/laying hens/day until it reach 50 g/laying hens/day. In the next phase, all chickens fasted for seven days then the chicken was given 10 g/laying hens on the first day. The feed was increased 10 g/laying hens every two days up to 120 g/laying hens/day. Data Collection of Feed conversion ratio (FCR), mortality rate, amount of feed, and egg production were taken at the start of re-feeding. The results showed that during the period of molting until refeeding, mortality was 3.6%, an increase in egg production was seen since week 1, peak of production was 78% at week 9 with FCR 2.3.  The results of statistical analysis showed significant differences (P<0.05) on the percentage of egg production between time periods after the treatment of feed reduction. As the conclusion, molting followed by refeeding in rejected laying hen influences weekly production performance by extending peak production period, optimal FCR and daily egg production.
Physicochemical Characteristics and Microbiological Quality of the Topside and Longissimus Dorsi of Indonesian Local Buffalo Meat
Authors: Sulaiman Noraimah Binti , Sumantri Cece , Arief Irma Isnafia , Budiman Cahyo
Published: June 2020

The physicochemical characteristics and microbiological quality of buffalo meat are influenced by differences in muscle type. This study aimed to evaluate the physiochemical characteristic and microbiological quality of the topside (active muscle) and longissimus dorsi (passive muscle) of Indonesian local buffalo meat. Samples used in this study were buffalo meat from local swamp buffalo, aged more than four years old on the topside and longissimus dorsi. This study used a completely randomized design, with three repetitions in each treatment. All data were analyzed using analysis of variance (ANOVA). The result of the study on the topside and longissimus dorsi area showed a significant difference in the pH and cholesterol levels of the buffalo meat. The longissimus dorsi area had a lower level of pH and cholesterol compared to the topside area. Furthermore, this longissimus dorsi meat has a higher color, protein, ash, fat, essential amino acid, and lactic acid bacterial (BAL) content than the topside meat. However, the topside meat had higher carbohydrate, essential fatty acid, Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) content compared to the longissimus dorsi meat. Longissimus dorsi meat had better physicochemical characteristics and microbiological quality than the topside meat
Aids in physics: Design and development
Authors: Hasim Norfaridatul Akmar Bt , Karim Mohd Mustamam Bin Abd , Rahman Nurulhuda Binti Abd
Published: June 2020

Electricity is found to be a difficult topic to learn due to its abstract concepts. Research showed that games based learning using dioramas can help students to interest and  enhance students’ understanding in learning abstract Physics topics. As a result, PhyKER Games was developed in order to assist students in the learning of the Electricity circuit topic. ADDIE model (analysis, design, development, implementation and evaluation) as instructional design and develope of PhyKER Games. Dioramas were added in PhyKER Games to depict real scenes. The information delivery and the flow of content follow the ADDIE phases theory. It is hoped that the PhyKER Games would be able to assist students in the learning of Electricity circuit terms of concept understanding and motivation level.
TERSİNE ZORBALIK (MOBBİNG) EYLEMLERİ VE TERSİNE ZORBALIKLA BAŞA ÇIKMA STRATEJİLERİ ÜZERİNE NİTEL BİR ARAŞTIRMA
Authors: BAYRAKÇI Eylem , DİNÇ Mehmet
Published: June 2020

Bu çalışma hangi eylemlerin yöneticiler tarafından tersine zorbalık olarak algılandığını belirleyerek zorbalıkla başa çıkma stratejilerini araştırmak amacıyla yapılmıştır. Bu amaçla, amaçlı örneklem yöntemlerinden kartopu örneklem yöntemine göre belirlenmiş farklı sektörlerde çalışan 8 yönetici ile görüşmeler yapılmış ve görüşme notlarının analizinde tümevarımsal içerik analizi kullanılmıştır. Araştırma sonucunda olumsuz eylemlerin, öncelikle iş ile ilgili olarak algılandığı daha sonraki aşamalarda kişiselleştirildiği görülmüştür. Zorbalık olarak algılanan olumsuz eylemler, üretkenlik karşıtı eylemler ve psikolojik baskılar olmak üzere iki ana tema altında toplanmıştır. Zorbalıkla başa çıkma stratejileri ise aktif stratejiler ve pasif stratejiler olmak üzere yine iki tema altında betimlenmiştir. Aktif stratejiler altında, uzlaşmaya çalışma, sosyal ve yönetsel destek arama, çatışma, zorbalıkla karşılık verme ve ayrılma stratejileri, pasif stratejiler altında, yok sayma, kaçınma ve geri çekilme/vazgeçme stratejileri kodlanmıştır. Yöneticiler tarafından sosyal/yönetsel destek arama ve uzlaşma stratejilerinin en etkili stratejiler olarak görüldüğü tespit edilmiştir. Aynı zamanda katılımcılar tarafından hem olumsuz eylemlerin zorbalık olarak algılanmasının hem de bu eylemlerle başa çıkma stratejilerinin birbirleriyle etkileşim halinde olan bir sürecin aşamaları olarak algılandığı sonucu bulunmuştur.
Mortality Analysis of the Pulmonary Department of the Emergency Hospital
Authors: Dubrovskaya I. I. , Puzyreva L. V. , Yanina O. A. , Didenko N. E. , Druzenko A. V. , Lobastov A. Yu.
Published: June 2020

The assessment of mortality in medical institutions is a reflection of the health status of the majority of the population and the assessment of preventive measures aimed at reducing the incidence of certain nosologies.

Purpose of the study: to assess mortality in the pulmonology department of the emergency hospital on-duty.

Materials and methods. The reporting data of the pulmonology department for the period from 2017 to 2019 were used. using statistical research methods.

Results. Pneumonia led to death in 35,2% of patients, which was associated with hospitalization of elderly and senile patients with a severe comorbid background, as well as the admission of patients leading an asocial lifestyle, late seeking medical help. Mortality from HIV infection caused death in 11,5% of patients, all in the late stages of infection 4B with the development of secondary diseases (bacterial pneumonia, pulmonary tuberculosis, pneumocystis pneumonia). Mortality from malignant neoplasms remains high during the study period, which indicates a late diagnosis. During the study period, oncology caused death in 13,2% of patients.

Conclusion. High mortality in the pulmonology department is due to late verification of pneumonia, HIV infection and malignant neoplasms.
Percutaneous-perventricular device closure of ventricular septal defect: mid-term follow-up.
Authors: Wang Long , Xie Lin , Ruan Weiqiang , Li Tao , Gan Changping , Lin Ke
Published: June 2020

Background: This report presents updated data and mid-term follow-up information to a former study introducing the novel technique of percutaneous-perventricular device closure of doubly committed subarterial ventricular septal defect. Methods: Thirty-eight patients were added to the former series. There were 54 patients in total who had isolated doubly committed subarterial ventricular septal defects and underwent percutaneous-perventricular device closure. Closure outcomes and possible complications were measured in the hospital and during the 2.5-year follow-up. Results: Surgery was successful in 53 patients (98.1%). There was no death, residual shunt, new valve regurgitation or arrhythmia either perioperatively or during the entire follow-up period. Only one patient developed pericardial effusion and tamponade in the former series. The mean hospital stay was 3.2±0.6 days (range, 3.0 to 6.0 days), and only one unsuccessful case needed blood transfusion (1.9%). Conclusions: The percutaneous-perventricular device closure of isolated doubly committed subarterial ventricular septal defects appeared to be safe. Close monitoring for bleeding is essential postoperatively, especially in younger patients. This technique is generally safe with acceptable mid-term follow-up.
The DLC-1 tumor suppressor is involved in regulating immunomodulation of human mesenchymal stem cells through interacting with the Notch1 protein
Authors: Na Tao , Zhang Kehua , Yuan Bao-Zhu
Published: June 2020

Background Immunomodulatory activities of human mesenchymal stem cells (hMSCs) has been widely recognized as the most critical function of hMSCs for exerting its therapeutic effects. However, the detailed mechanisms responsible for regulating the immunomodulation of hMSCs still remain largely unknown. Previous studies revealed that the Notch1 protein exerted a pro-immunomodulatory function probably through interacting with the protein(s) subjective to proteasome-mediated protein degradation. The DLC-1 protein represents a well characterized tumor suppressor subjective to proteasome-mediated degradation. However, the detailed signaling pathway of Notch1 and the involvement of DLC-1 in regulating the immunomodulation of hMSCs have not been studied before. Methods The transfection with cDNA or siRNA into hMSCs assisted by co-culture of hMSCs with peripheral blood mononuclear cells and small molecule inhibitors of signaling proteins, followed by immunoprecipitation, Western blotting, RT-PCR, and flowcytometry, were employed to characterize the Notch1 signaling, to identify DLC-1 as a candidate proteasome-targeted protein, and to characterize DLC-1 signaling pathway and its interaction with the Notch1 signaling, in the regulation of immunomodulation of hMSCs, specifically, the inhibition of pro-inflammatory CD4+-Th1 lymphocytes, and the release of immunomodulatory molecule IDO1. Statistical analysis One-way ANOVA was utilized as a statistical tool to analyze the data presented as means ± SEM of at least three separate experiments. Results The present study revealed that the Notch1-Hey1 axis, but not the Notch1-Hes1 axis, was likely responsible for mediating the pro-immunomodulatory function of the Notch1 signaling. The DLC-1 protein was found subjective to proteasome-mediated protein degradation mediated by the DDB1 and FBXW5 E3 ligases and served as an inhibitor of the immunomodulation of hMSCs through inhibiting Rock1, but not Rock2, downstream the DLC-1 signaling. The Notch1 signaling in the Notch1-Hey1 pathway and the DLC-1 signaling in the DLC-1-Rock1-FBXW5 pathway exhibited a mutual exclusion interaction in the regulation of immunomodulation of hMSCs. Conclusions The present study uncovers a novel function of DLC-1 tumor suppressor in regulating the immunomodulation of hMSCs. It also proposes a novel mutual exclusion mechanism between the DLC-1 signaling and the Notch1 signaling that is possibly responsible for fine-tuning the immunomodulation of hMSCs with different clinical implications in hMSCs therapy.
Communication of advance care planning decisions: a retrospective cohort study of documents in general practice
Authors: Panozzo Laura , Harvey Pam , Adams Meagan-Jane , O'Connor Dennis , Ward Bernadette
Published: June 2020

Background Doctors, particularly general practitioners, play a significant role in assisting patients to create advance care plans. When medically indicated, these documents are important tools to promote congruence between end-of-life care and patient’s personal preferences. Despite this, little is known regarding the availability of these documents in hospitals. The aim of this study was to identify the proportion of people who died in hospital without an advance care plan and how many of these had advance care planning (ACP) documents in their general practice records.Methods A retrospective cohort study was conducted of patient hospital records with manual linkage to general practice records. The large regional hospital in Victoria, Australia has a catchment population in excess of 300,000 people. The study sample was patients aged 75 years and over who died in the hospital between 1 January 2016 and 31 December 2017. The hospital records of these patients were examined to identify those which did not have a system alert for ACP documents on the file. Alerted ACP documents were limited to those legislated in the state of Victoria: advance care plan, Enduring Power of Attorney (Medical Treatment) or Enduring Power of Guardianship. Where no ACP document system alert was found in the hospital record, the patient’s nominated general practice was consented to participate and the corresponding general practice record was examined. Data were analysed using descriptive statistics.Results Of the 406 patients who died in hospital, 76.1% (309) did not have a system alert for any ACP document. Of the 309 hospital records without a system alert, 144 (46.7%) corresponding general practice records were examined. Of these, 14.6% included at least one ACP document, including four advance care plans, that were not available in hospital.Conclusions Unless ACP documents are consistently communicated from general practice, patient’s preferences may be unknown during end-of-life care. It is important that both doctors and patients are supported to use connected electronic health records to ensure that documents are readily available to healthcare staff when they are required.
Higher activity of monodehydroascorbate reductase and lower activities of leaf and spike vacuolar invertase and glutathione S-transferase reveals higher number of grains per spike in spring wheat genotypes grown under well-watered and drought conditions
Authors: Shokat sajid , Großkinsky Dominik K. , Roitsch Thomas , Liu Fulai
Published: June 2020

Background: To improve our understanding about the physiological mechanism of grain yield reduction at anthesis, three spring wheat genotypes (L1, L2 and L3) having contrasting yield potential under drought in field were investigated under controlled greenhouse conditions., drought stress was imposed at anthesis stage by withholding irrigation until all plant available water was depleted, while well-watered control plants were kept at 95% pot water holding capacity. Results: Compared to genotype L1 and L2, pronounced decrease in grain number (NGS), grain yield (GY) and harvest index (HI) were found in genotype L3, mainly due to its greater kernel abortion (KA) under drought. A significant positive correlation of leaf monodehydroascorbate reductase (MDHAR) with both NGS and HI was observed. In contrast, significant negative correlations of glutathione S-transferase (GST) and vacuolar invertase (vacInv) both within source and sink with NGS and HI were found. Likewise, a significant negative correlation of leaf abscisic acid (ABA) with NGS was noticed. Moreover, leaf aldolase and cell wall peroxidase (cwPOX) activities were significantly and positively associated with TKW. Conclusion: Collectively, distinct physiological markers were correlating with yield traits and higher activity of leaf aldolase and cwPOX may be chosen as predictive bio-markers for higher TKW. Also, higher activity of MDHAR within the leaf can be selected as a predictive bio-marker for higher NGS in wheat under drought. Whereas, lower activity of vacInv and GST both within leaf and spike can be selected as bio-markers for higher NGS and HI. The results highlighted the role of antioxidant and carbohydrate-metabolic enzymes in the modulation of source-sink balance in wheat crops, which could be used as bio-signatures for breeding and selection of drought-resilient wheat genotypes for a future drier climate.
Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance via PTEN-mediated crosstalk between the PI3K/Akt and Erk/MAPKs signaling pathways in the skeletal muscles of db/db mice
Authors: Chen Guang , Fan Xiao-yan , Zheng Xiao-peng , Jin Yue-lei , Liu Ying , Liu Shuang-chun
Published: June 2020

Background: Globally, 1 in 11 adults have diabetes mellitus and 90% of the cases are type 2 diabetes mellitus. Asia is the epicenter of this global type 2 diabetes mellitus epidemic. Type 2 diabetes mellitus and its complications have contributed significantly to the burden of mortality and disability worldwide. Insulin resistance is a central defect in type 2 diabetes mellitus, and although multiple drugs have been developed to ameliorate insulin resistance, the limitations and accompanying side effects cannot be ignored. Thus more effective methods are required to improve insulin resistance. Methods: In the current study, db/m and db/db mice were injected with human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) via tail vein injection, intraperitoneal injection and skeletal muscle injection. Body weight, fasting blood glucose and the survival rates were monitored. Furthermore, the anti-insulin resistance effects and potential mechanisms of transplanted HUC-MSCs were investigated in db/db mice in vivo . Results: The results showed that HUC-MSC transplantation by skeletal muscle injection was safer compared with tail vein injection and intraperitoneal injection, and the survival rate reached 100% in the skeletal muscle injection transplanted mice. HUC-MSCs can stabilize localization and differentiation in skeletal muscle tissue and significantly ameliorate insulin resistance. Potential regulatory mechanisms are associated with downregulation of inflammation; regulating the balance between PI3K/Akt and ERK/MAPK signaling pathway via PTEN, but was not associated with the IGF-1/IGF-1R signaling pathway. Conclusions: These results suggest HUC-MSC transplantation may be a novel therapeutic direction to prevent insulin resistance and increase insulin sensitivity, and skeletal muscle injection was the safest and most effective way.
Low UV-C stress modulates Chlamydomonas reinhardtii biomass composition and oxidative stress response through proteomic and metabolomic changes involving novel signalers and effectors
Authors: Colina Francisco , Carbó María , Meijón Mónica , Cañal María Jesús , Valledor Luis
Published: June 2020

Background: The exposition of microalgae and plants to low UV-C radiation dosages can improve their biomass composition and stress tolerance. Despite UV-C shares these effects with UV-A/B but at much lower dosages, UV-C sensing and signal mechanisms are still mostly unknown. Thus, we have described and integrated the proteometabolomic and physiological changes occurring in Chlamydomonas reinhardtii –a simple Plantae model– into the first 24 h after a short and low intensity UV-C irradiation in order to reconstruct the microalgae response system to this stress. Results : The microalgae response was characterized by increased redox homeostasis, ROS scavenging and protein damage repair/avoidance elements. These processes were upregulated along others related to the modulation of photosynthetic electron flux, carbon fixation and C/N metabolism. These changes, attributed to either direct UV-C-, ROS- or redox unbalances-associated damage, trigger a response process involving novel signaling intermediaries and effectors as the translation modulator FAP204, a PP2A like protein and a novel DYRK kinase. These elements were found linked to the modulation of Chlamydomonas biomass composition (starch accumulation) and proliferation, within an UV-C response probably modulated by different epigenetic factors.Conclusion: Chosen multiomics integration approach was able to describe many fast changes, including biomass composition and ROS stress tolerance, as a response to a low intensity UV-C stress. Moreover, the employed omics and systems biology approach placed many previously unidentified protein and metabolites at the center of these changes. These elements would be promising targets for the characterization of this stress response in microalgae and plants and the engineering of more productive microalgae strains.
From Invention to Industry from a social movement perspective: The emergence of the 3D Printing Industry
Authors: Lechner Christian , Pervaiz Abeer
Published: June 2020

In the entrepreneurship literature, the phenomenon of industry emergence has been largely investigated from an institutional perspective. Appropriate institutions would allow then a group of individual entrepreneurs (‘the heroes’) to create an industry through innovative ventures. New ventures create new industries and firm entry, survival and exit drive industry evolution. Our research, however, explores what creates the favorable set of circumstances for new ventures to emerge and focuses on the pre-emergence phase and we propose that the patterns of emergence resemble those of social movements. Through an actor perspective, this research highlights the existence of diverse actors, not necessarily entrepreneurs, who are necessary to trigger a collective action during the pre-emergence phase of industries. This research is also distinct from entrepreneurial ecosystems as its development already requires some successful entrepreneurial action. The 3D Printing industry was chosen as a single longitudinal case study, where the actors are the embedded units of analysis. The findings of the study lead to the identification of three aggregate dimensions; “Social Movement Composition”, Temporal Engagement” and “Coalitions Development”, that were prevalent during the pre-emergence phase of the 3D printing industry. Our propositions emphasize the importance of large collective action and the role of multiple actors in order to create the conditions for, first, firm emergence and the second, to the process of industry emergence.