bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of IgG Antibody Response against SARS-CoV-2 (COVID-19) in the Cypriot Population
Authors: Krashias George , Deeba Elie , Constantinou Astero , Hadjiagapiou Maria , Koptides Dana , Richter Jan , Tryfonos Christina , Bashiardes Stavros , Lambrianides Anastasia , Loizidou Maria A. , Hadjisavvas Andreas , Panayiotidis Mihalis I. , Christodoulou Christina
Published: January 2022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has hit its second year and continues to damage lives and livelihoods across the globe. There continues to be a global effort to present serological data on SARS-CoV-2 antibodies in different individuals. As such, this study aimed to characterize the seroprevalence of SARS-CoV-2 antibodies in the Cypriot population for the first time since the pandemic started. Our results show that a majority of people infected with SARS-CoV-2 developed IgG antibodies against the virus, whether anti-NP, anti-S1RBD, or both, at least 20 days after their infection. Additionally, the percentage of people with at least one antibody against SARS-CoV-2 in the group of volunteers deemed SARS-CoV-2 negative via RT-PCR or who remain untested/undetermined (14.43%) is comparable to other reported percentages worldwide, ranging anywhere from 0.2% to 24%. We postulate that these percentages reflect the underreporting of true infections in the population, and also show the steady increase of herd immunity. Additionally, we showed a significantly marked decrease in anti-NP IgG antibodies in contrast to relatively stable levels of anti-S1RBD IgG antibodies in previously infected individuals across time.
Reduction of Deuterium Level Supports Resistance of Neurons to Glucose Deprivation and Hypoxia: Study in Cultures of Neurons and on Animals
Authors: Kravtsov Alexandr , Kozin Stanislav , Basov Alexandr , Butina Elena , Baryshev Mikhail , Malyshko Vadim , Moiseev Arkady , Elkina Anna , Dzhimak Stepan
Published: January 2022

The effect of a reduced deuterium (D) content in the incubation medium on the survival of cultured neurons in vitro and under glucose deprivation was studied. In addition, we studied the effect of a decrease in the deuterium content in the rat brain on oxidative processes in the nervous tissue, its antioxidant protection, and training of rats in the T-shaped maze test under hypoxic conditions. For experiments with cultures of neurons, 7–8-day cultures of cerebellar neurons were used. Determination of the rate of neuronal death in cultures was carried out using propidium iodide. Acute hypoxia with hypercapnia was simulated in rats by placing them in sealed vessels with a capacity of 1 L. The effect on oxidative processes in brain tissues was assessed by changes in the level of free radical oxidation and malondialdehyde. The effect on the antioxidant system of the brain was assessed by the activity of catalase. The study in the T-maze was carried out in accordance with the generally accepted methodology, the skill of alternating right-sided and left-sided loops on positive reinforcement was developed. This work has shown that a decrease in the deuterium content in the incubation medium to a level of −357‰ has a neuroprotective effect, increasing the survival rate of cultured neurons under glucose deprivation. When exposed to hypoxia, a preliminary decrease in the deuterium content in the rat brain to −261‰ prevents the development of oxidative stress in their nervous tissue and preserves the learning ability of animals in the T-shaped maze test at the level of the control group. A similar protective effect during the modification of the 2H/1H internal environment of the body by the consumption of DDW can potentially be used for the prevention of pathological conditions associated with the development of oxidative stress with damage to the central nervous system.
In Vitro Antineoplastic and Antiviral Activity and In Vivo Toxicity of Geum urbanum L. Extracts
Authors: Zaharieva Maya M. , Dimitrova Lyudmila L. , Philipov Stanislav , Nikolova Ivanka , Vilhelmova Neli , Grozdanov Petar , Nikolova Nadya , Popova Milena , Bankova Vassya , Konstantinov Spiro M. , Zheleva-Dimitrova Dimitrina , Najdenski Hristo M.
Published: January 2022

This study evaluated the in vitro antineoplastic and antiviral potential and in vivo toxicity of twelve extracts with different polarity obtained from the herbaceous perennial plant Geum urbanum L. (Rosaceae). In vitro cytotoxicity was determined by ISO 10993-5/2009 on bladder cancer, (T-24 and BC-3C), liver carcinoma (HEP-G2) and normal embryonic kidney (HEK-293) cell lines. The antineoplastic activity was elucidated through assays of cell clonogenicity, apoptosis induction, nuclear factor kappa B p65 (NFκB p65) activation and total glutathione levels. Neutral red uptake study was applied for antiviral activity. The most promising G. urbanum extract was analyzed by UHPLC–HRMS. The acute in vivo toxicity analysis was carried out following OEDC 423. The ethyl acetate extract of aerial parts (EtOAc-AP) exhibited the strongest antineoplastic activity on bladder cancer cell lines (IC50 = 21.33–25.28 µg/mL) by inducing apoptosis and inhibiting NFκB p65 and cell clonogenicity. EtOAc and n-butanol extracts showed moderate antiviral activity against human adenovirus type 5 and human simplex virus type I. Seventy four secondary metabolites (gallic and ellagic acid derivatives, phenolic acids, flavonoids, etc.) were identified in EtOAc-AP by UHPLC–HRMS. This extract induced no signs of acute toxicity in liver and kidney specimens of H-albino mice in doses up to 210 mg/kg. In conclusion, our study contributes substantially to the detailed pharmacological characterization of G. urbanum, thus helping the development of health-promoting phytopreparations.
Impact of Eutectic Solvents Utilization in the Microwave Assisted Extraction of Proanthocyanidins from Grape Pomace
Authors: Neto Rodrigo T. , Santos Sónia A. O. , Oliveira Joana , Silvestre Armando J. D.
Published: January 2022

The extraction of proanthocyanidins (PACs), despite being an important and limiting aspect of their industrial application, is still largely unexplored. Herein, the possibility of combining eutectic solvents (ESs) with microwave assisted extraction (MAE) in the extraction of PACs from grape pomace (GP) is explored, aiming to improve not only the extraction yield but also the mean degree of polymerization (mDP). The combination of choline chloride with lactic acid was shown to be the most effective combination for PACs extraction yield (135 mgPAC/gGP) and, despite the occurrence of some depolymerization, also enabled us to achieve the highest mDP (7.13). Additionally, the combination with MAE enabled the process to be completed in 3.56 min, resulting in a considerably reduced extraction time.
Tetrabromobisphenol A Disturbs Brain Development in Both Thyroid Hormone-Dependent and -Independent Manners in Xenopus laevis
Authors: Dong Mengqi , Li Yuanyuan , Zhu Min , Li Jinbo , Qin Zhanfen
Published: January 2022

Although tetrabromobisphenol A (TBBPA) has been well proven to disturb TH signaling in both in vitro and in vivo assays, it is still unclear whether TBBPA can affect brain development due to TH signaling disruption. Here, we employed the T3-induced Xenopus metamorphosis assay (TIXMA) and the spontaneous metamorphosis assay to address this issue. In the TIXMA, 5–500 nmol/L TBBPA affected T3-induced TH-response gene expression and T3-induced brain development (brain morphological changes, cell proliferation, and neurodifferentiation) at premetamorphic stages in a complicated biphasic concentration-response manner. Notably, 500 nmol/L TBBPA treatment alone exerted a stimulatory effect on tadpole growth and brain development at these stages, in parallel with a lack of TH signaling activation, suggesting the involvement of other signaling pathways. As expected, at the metamorphic climax, we observed inhibitory effects of 50–500 nmol/L TBBPA on metamorphic development and brain development, which was in agreement with the antagonistic effects of higher concentrations on T3-induced brain development at premetamorphic stages. Taken together, all results demonstrate that TBBPA can disturb TH signaling and subsequently interfere with TH-dependent brain development in Xenopus; meanwhile, other signaling pathways besides TH signaling could be involved in this process. Our study improves the understanding of the effects of TBBPA on vertebrate brain development.
A Review of Microbial Mediated Iron Nanoparticles (IONPs) and Its Biomedical Applications
Authors: Nadeem Muhammad , Khan Rijma , Shah Nausheen , Bangash Ishrat Rehman , Abbasi Bilal Haider , Hano Christophe , Liu Chunzhao , Ullah Sana , Hashmi Syed Salman , Nadhman Akhtar , Celli Jonathan
Published: January 2022

Nanotechnology is a booming avenue in science and has a multitude of applications in health, agriculture, and industry. It exploits materials’ size at nanoscale (1–100 nm) known as nanoparticles (NPs). These nanoscale constituents are made via chemical, physical, and biological methods; however, the biological approach offers multiple benefits over the other counterparts. This method utilizes various biological resources for synthesis (microbes, plants, and others), which act as a reducing and capping agent. Among these sources, microbes provide an excellent platform for synthesis and have been recently exploited in the synthesis of various metallic NPs, in particular iron. Owing to their biocompatible nature, superparamagnetic properties, small size efficient, permeability, and absorption, they have become an integral part of biomedical research. This review focuses on microbial synthesis of iron oxide nanoparticles using various species of bacteria, fungi, and yeast. Possible applications and challenges that need to be addressed have also been discussed in the review; in particular, their antimicrobial and anticancer potentials are discussed in detail along with possible mechanisms. Moreover, some other possible biomedical applications are also highlighted. Although iron oxide nanoparticles have revolutionized biomedical research, issues such as cytotoxicity and biodegradability are still a major bottleneck in the commercialization of these nanoparticle-based products. Addressing these issues should be the topmost priority so that the biomedical industry can reap maximum benefit from iron oxide nanoparticle-based products.
Asymmetric Interfaces in Epitaxial Off-Stoichiometric Fe3+xSi1−x/Ge/Fe3+xSi1−x Hybrid Structures: Effect on Magnetic and Electric Transport Properties
Authors: Tarasov Anton S. , Tarasov Ivan A. , Yakovlev Ivan A. , Rautskii Mikhail V. , Bondarev Ilya A. , Lukyanenko Anna V. , Platunov Mikhail S. , Volochaev Mikhail N. , Efimov Dmitriy D. , Goikhman Aleksandr Yu. , Belyaev Boris A. , Baron Filipp A. , Shanidze Lev V. , Farle Michael , Varnakov Sergey N. , Ovchinnikov Sergei G. , Volkov Nikita V.
Published: January 2022

Three-layer iron-rich Fe3+xSi1−x/Ge/Fe3+xSi1−x (0.2 < x < 0.64) heterostructures on a Si(111) surface with Ge thicknesses of 4 nm and 7 nm were grown by molecular beam epitaxy. Systematic studies of the structural and morphological properties of the synthesized samples have shown that an increase in the Ge thickness causes a prolonged atomic diffusion through the interfaces, which significantly increases the lattice misfits in the Ge/Fe3+xSi1−x heterosystem due to the incorporation of Ge atoms into the Fe3+xSi1−x bottom layer. The resultant lowering of the total free energy caused by the development of the surface roughness results in a transition from an epitaxial to a polycrystalline growth of the upper Fe3+xSi1−x. The average lattice distortion and residual stress of the upper Fe3+xSi1−x were determined by electron diffraction and theoretical calculations to be equivalent to 0.2 GPa for the upper epitaxial layer with a volume misfit of −0.63% compared with a undistorted counterpart. The volume misfit follows the resultant interatomic misfit of |0.42|% with the bottom Ge layer, independently determined by atomic force microscopy. The variation in structural order and morphology significantly changes the magnetic properties of the upper Fe3+xSi1−x layer and leads to a subtle effect on the transport properties of the Ge layer. Both hysteresis loops and FMR spectra differ for the structures with 4 nm and 7 nm Ge layers. The FMR spectra exhibit two distinct absorption lines corresponding to two layers of ferromagnetic Fe3+xSi1−x films. At the same time, a third FMR line appears in the sample with the thicker Ge. The angular dependences of the resonance field of the FMR spectra measured in the plane of the film have a pronounced easy-axis type anisotropy, as well as an anisotropy corresponding to the cubic crystal symmetry of Fe3+xSi1−x, which implies the epitaxial orientation relationship of Fe3+xSi1−x (111)[0−11] || Ge(111)[1−10] || Fe3+xSi1−x (111)[0−11] || Si(111)[1−10]. Calculated from ferromagnetic resonance (FMR) data saturation magnetization exceeds 1000 kA/m. The temperature dependence of the electrical resistivity of a Ge layer with thicknesses of 4 nm and 7 nm is of semiconducting type, which is, however, determined by different transport mechanisms.
Wear of Functionally Graded Coatings under Frictional Heating Conditions
Authors: Zelentsov Vladimir B. , Lapina Polina A. , Mitrin Boris I.
Published: January 2022

Multilayered and functionally graded coatings are extensively used for protection against wear of the working surfaces of mechanisms and machines subjected to sliding contact. The paper considers the problem of wear of a strip made of a functionally graded material, taking into account the heating of the sliding contact from friction. Wear is modeled by a moving strip along the surface of a hard abrasive in the form of a half-plane. With the help of the integral Laplace transform with respect to time, the solutions are constructed as convolutions from the law of the introduction of an abrasive into the strip and the original in the form of a contour integral of the inverse Laplace transform. The study of the integrands of contour quadratures in the complex plane allowed determination of the regions of stable solutions to the problem. Unstable solutions of the problem lead to the concept of thermoelastic instability of the contact with friction and formed regions of unstable solutions. The solutions obtained made it possible to determine a formula for the coefficient of functionally graded inhomogeneity of the coating material and to study its effect on the occurrence of thermoelastic instability of the contact taking friction into account, as well as on its main characteristics: temperature, displacement, stress and wear of the functionally graded material of the coating. The effects of the abrasive speed, contact stresses and temperature on wear of the coating with the functionally graded inhomogeneity of the material by the depth were investigated.
Effect of Salt Stress and Foliar Application of Salicylic Acid on Morphological, Biochemical, Anatomical, and Productivity Characteristics of Cowpea (Vigna unguiculata L.) Plants
Authors: El-Taher Ahmed M. , Abd El-Raouf Hany S. , Osman Nahid A. , Azoz Samah N. , Omar Magdy A. , Elkelish Amr , Abd El-Hady Mahmoud A. M.
Published: January 2022

The present study aimed to investigate the impact of salinity on vegetative growth, chemical constituents, and yields of cowpeas (Vigna unguiculata) and the possible benefits of salicylic acid (SA) on these plants after damage from salinity. To achieve these objectives, two pot experiments were carried out at the Faculty of Agriculture, Al-Azhar University, Egypt, during the two growing seasons of 2019 and 2020. The results revealed that salinity significantly decreased, and SA treatment substantially increased the plant height, number of compound leaves, number of internodes per plant, fresh weights of leaves and stems, productivity, photosynthetic pigments content, and concentrations of nitrogen (N), phosphorus (P), and potassium (K) of the cowpea plants compared with the control. The anatomical structure of stems and leaves of the plants were also investigated, and it was found that positive variations in the anatomical structure of the median portion of the main stems and blades of mature foliage leaves were detected in the stressed and SA-treated plants. In conclusion, SA treatment increased the salt stress tolerance of cowpea plants by improving the morphological and physiological attributes of the plants.
Physiological Characteristics of Cultivated Tepary Bean (Phaseolus acutifolius A. Gray) and Its Wild Relatives Grown at High Temperature and Acid Soil Stress Conditions in the Amazon Region of Colombia
Authors: Suárez Juan Carlos , Contreras Amara Tatiana , Anzola José Alexander , Vanegas José Iván , Rao Idupulapati M.
Published: January 2022

Common bean (Phaseolus vulgaris L.) is sensitive to different types of abiotic stresses (drought, high temperature, low soil fertility, and acid soil), and this may limit its adaptation and consequently to its yield under stress. Because of this, a sister species, tepary bean (Phaseolus acutifolius A. Gray), has recently gained attention in breeding for improved abiotic stress tolerance in common bean. In this study, we evaluated the adaptation of 302 accessions of tepary bean (Phaseolus acutifolius A. Gray) and its wild relatives (grouped in four types of tepary bean genetic resource: cultivated, acutifolius regressive, acutifolius wild, tenuifolius wild) when grown under high temperature and acid soil conditions with aluminum toxicity in the Amazon region of Colombia. Our objective was to determine differences among four types of tepary bean genetic resource in their morpho-phenological, agronomic, and physiological responses to combined high temperature and acid soil stress conditions. We found that cultivated P. acutifolius var acutifolius presented a greater number of pods per plant, as well as larger seeds and a greater number of seeds per pod. Some traits, such as root biomass, days to flowering and physiological maturity, specific leaf area, and stomatal density, showed significant differences between types of tepary bean genetic resource, probably contributing to difference in adaptation to combined stress conditions of high temperature and acid soil conditions. The photochemical quenching (qP) was higher in cultivated P. acutifolius var. acutifolius, while energy dissipation by non-photochemical quenching (NPQ) in the form of heat and the coefficient of non-photochemical dissipation (qN) were higher in acutifolius regressive and tenuifolius wild accessions. We have identified 6 accessions of cultivated and 19 accessions of tenuifolius wild that exhibited grain yields above 1800 kg ha−1. These accessions could be suitable to use as parents to improve dry seed production of tepary bean under combined stress conditions of high temperature and acid soil.
Pharmacological Efficacy of Tamarix aphylla: A Comprehensive Review
Authors: Alshehri Saad Ali , Wahab Shadma , Abullais Shahabe Saquib , Das Gotam , Hani Umme , Ahmad Wasim , Amir Mohd , Ahmad Ayaz , Kandasamy Geetha , Vasudevan Rajalakshimi
Published: January 2022

Tamarix aphylla is a well-known species of the genus Tamarix. T. aphylla (Tamaricaceae) is a perennial tree in Asia, the Middle East, and Central Africa. It is used as a carminative diuretic in tuberculosis, leprosy, and hepatitis. Various pharmacological properties have been shown by T. aphylla, such as antidiabetic, anti-inflammatory, antibacterial, antifungal, anticholinesterase, and wound-healing activity. However, T. aphylla has not received much attention for its secondary metabolites and bioactive constituents. Research has shown that this plant has hidden potential that needs to be explored. This review aims to cover botanical classification, geographical distribution, taxonomy, ethnobotanical uses, and the phytochemical compounds found in T. aphylla. The toxicology and pharmacological effects of T. aphylla are also discussed. We examined various scholarly resources to gather information on T. aphylla, including Google Scholar, Scopus, Science Direct, Springer Link, PubMed, and Web of Science. The finding of this work validates a connection between T. aphylla in conventional medicine and its antidiabetic, antibacterial, anti-inflammatory, wound-healing, antifungal, anticholinesterase, and other biological effects. T. aphylla’s entire plant (such as bark, leaves, fruits) and root extracts have been used to treat hypertension, stomach discomfort, hair loss, cough and asthma, abscesses, wounds, rheumatism, jaundice, fever, tuberculosis, and gum and tooth infection. The phytochemical screening revealed that noticeably all extracts were devoid of alkaloids, followed by the presence of tannins. In addition, different parts have revealed the existence of steroids, flavonoids, cardiac glycosides, and byproducts of gallic acid and ellagic acid. T. aphylla has shown many valuable activities against different diseases and supports its traditional uses. Therefore, high-quality preclinical research and well-designated clinical trials are needed to establish the efficacy and safety of this plant in humans.
Major changes affecting EU funded loan and equity scheme management in 2021-2027 budgetary period
Authors: Bató Márk
Published: January 2022

Approximately ten percent of support from the European Union structural funds sources was utilised as financial instruments in the 2014-2020 EU budgetary period. The term ‘financial instruments’ represents support in the form of loans and capital injections in Hungary. Programmes for 2021-2027 have not been finalised yet, but major amounts of money are expected to be used in the form of financial instruments. Therefore, one should review the changes affecting the criteria to use EU structural funds, which determine development policies in the next period regarding loan and equity schemes. Both the EU and the Hungarian regulatory framework have been established, they can be studied and used as the starting point of further planning. In this paper the major components of the relevant regulatory framework including its practical conclusions to be expected are discussed.
Peran Anggaran Informasi Akuntansi Terhadap Pusat Pertanggungjawaban Biaya
Authors: Hertati Lesi
Published: January 2022

Tanggungjawab timbul karena adanya pendelegasian wewenang dari suatu tingkat manajemen yang lebih tinggi ke tingkat yang lebih rendah. Untuk mengetahui tanggung jawabnya, manajemen bawah harus mengetahui dengan jelas wewenang apa yang harus didelegasikan oleh atasannya. Manajemen bawah harus bertanggungjawab terhadap pelaksanaan wewenang yang diberikan kepadanya. Oleh karenanya, timbul kebutuhan organisasi akan wewenang informasi akuntansi untuk menilai pertanggungjawaban pelaksanaan wewenang. Uji validitas dilakukan yang digunakan untuk menentukan kelayakan item dalam daftar pertanyaan untuk menentukan variabel yang di uji. Varians yang dikenal SEM PLS untuk menguji hipotesis dilakukan untuk menguji variabel eksogen terhadap variabel endogen secara langsung yaitu dengan membandingkan t-tabel dan t-hitung. Masing-masing t hasil perhitungan ini kemudian dibandingkan dengan t - tabel yang diperoleh dengan menggunakan taraf kesalahan 0,05. Populasi target dari penelitian ini adalah SKPD kabupaten/kota di Sumatera Selatan. Pengumpulkan data yang menjadi sumber data Primer yaitu metode pengumpulan data yang dilakukan sendiri oleh penulis secara langsung ke objek penelitian. Adapun metode ini diperoleh dengan cara: (a) Wawancara (Interview) dan (b) Observast (Observation). Kemudian data Sekunder yaitu metode pengumpulan data dalam bentuk hasil publikasi atau data yang sudah dikumpulkan oleh pihak atau instansi lain. Adapun metode ini diperoleh dengan cara pengumpulan data dimana data-data yang berhubungan dengan objek penelitian diperoleh. Penelitian ini untuk mengetahui peran anggaran, informasi akuntansi terhadap pusat pertanggungjawaban biaya. Hasil penelitian membuktikan bahwa pusat pertanggungjawaban angaran dapat digunakan untuk mengawasi, menganalisis, melaksanakan, mengendalikan dan mengambil keputusan. Metode pengumpulan data menggunakan Structural Equation Model (SEM) dengan metode Partial Least Square (PLS).
Penerapan Metode IPA dan PGCV untuk Mengukur Tingkat Kepuasan Konsumen Coffee Shop
Authors: Rizqiyah P E , Subagio R T , Putri T E
Published: January 2022

Upaya untuk mengetahui tingkat kinerja kualitas pelayanan dan kualitas produk di Oksigen Coffee saat ini dilakukan survei kepuasan konsumen, survei dilakukan secara manual dan bentuk wawancara belum berdasarkan indikator-indikator sebagai standar yang diperlukan untuk keseragaman materi survei sehingga mengalami kesulitan untuk melakukan analisa lebih lanjut. Maka dibutuhkan adanya sistem untuk mengukur tingkat kepuasan konsumen dengan menerapkan metode analisis yang mempertimbangkan tingkat kepentingan atau harapan dari responden. Tujuan dari penelitian ini adalah menerapkan penggabungan 2 metode analisa yaitu metode IPA yang digunakan untuk mengetahui atribut yang diperbaiki atau dikurangi berdasarkan letak pada pemetaan kuadrannya, sedangkan metode PGCV digunakan untuk mengetahui urutan prioritas perbaikan atribut yang harus diperbaiki atau ditingkatkan berdasarkan nilai potensialnya serta hasil dari metode PGCV merupakan hasil akhir dalam pengukuran tingkat kepuasan konsumen. Hasil penelitian ini adalah sistem yang mampu mengetahui tingkat kepuasan konsumen berdasarkan tingkat kinerja dan tingkat kepentingan atribut yang harus diperbaiki atau dikurangi dan urutan prioritas perbaikannya.
Analisa Manajemen Risiko E-Learning Edlink Menggunakan Metode NIST SP 800-30 Revisi 1
Authors: Putro A A , Ambarwati A , Setiawan E
Published: January 2022

EdLink merupakan produk e-learning yang mendukung pembelajaran online di perguruan tinggi. EdLink tersedia dalam platform android, IOS, dan web browser. Pada tahun 2020 pengguna EdLink tercatat 100 perguruan tinggi dan terjadi peningkatan sampai dengan 270 perguruan tinggi di seluruh Indonesia pada tahun 2021. Dengan adanya kebijakan pembelajaran daring akibat dampak COVID-19 dan kebutuhan pasar yang meningkat, maka peneliti melakukan analisis manajemen risiko EdLink dengan menggunakan metode NIST SP 800-30 Revisi 1. Metode NIST SP 800-30 Revisi 1 telah dibandingkan dengan metode lain dan dipilih karena sesuai dengan kebutuhan penelitian. Dengan menggunakan metode NIST SP 800-30 Revisi 1 akan diketahui risiko yang mungkin terjadi pada EdLink beserta dengan rekomendasi kontrol EdLink. Rekomendasi kontrol yang diberikan diharapkan dapat meminimalisir peluang munculnya risiko yang menyebabkan dampak buruk bagi aplikasi EdLink maupun perusahaan pengembang. Berdasarkan hasil penelitian yang telah dilakukan dapat diketahui terdapat tujuh risiko dengan rincian tiga tingkat very high dan empat tingkat high. Peneliti telah memberikan tujuh rekomendasi kontrol untuk risiko dengan tingkat very high dan high.
PENGARUH STRATEGI.RESOURCE BASED VIEW DAN.ORIENTASI.KEWIRAUSAHAAN TERHADAP KEUNGGULAN.BERSAING DI SENTRA JEANS CIHAMPELAS BANDUNG
Authors: Sartika Siva , Handayani Trustorini
Published: January 2022

Penilitian ini bertujuan untuk mengatahui tanggapan pelaku usaha tentang Resource Based View di Sentra Jeans Cihampelas Bandung, untuk mengathui tanggapan pelaku usaha tentang Orientasi Kewirausahaan di Sentra Jeans Cihampelas Bandung. Penelitian yang digunakan yaitu metode uji deskriptif dan verifikatif dimana sampel menggunakan sebanyak 30 responden kepada pelaku usaha di Sentra Jeans Cihampelas Bandung dari 30 populasi maka karena itu menggunakan metode analisis linier berganda. Sebelumnya dilakukan uji normalitas, uji multikolineritas, uji heteroskedastisitas, dan uji verifikatif. Hasil penelitian menunjukan hasil analisis desktiptif, Variabel Resource Based View memiliki kategori yang cukup baik, Variabel Orientasi Kewiraushaan memiliki kategori yang cukup baik lalu untuk Variabel Keunggulan Bersaing.dengan kategori yang cukup baik Lalu Analisis dengan cara verifikatif menunjukan bahwa Resource Based View secara parsial signifikan terhadap Keunggulan Bersaing, Orientasi Kewirausahaan secara parsial signifikan terhadap Keunggulan.Bersaing dan juga Resource Based View dan Orientasi Kewirausahaan secara simultan signifikan terhadap Keunggulan Bersaing.
Statistical Literacy as a Way to Achieve Social Consensus
Authors: Karmanov M. V. , Zolotareva O. A.
Published: January 2022

The maintenance of civil peace and harmony in the Russian state from time immemorial has been defined as a priority that allows maintaining the integrity of both state and territorial. Global processes taking place in the world, epidemic waves of viruses, incessant local wars, diligent attempts to separate people and peoples bring to the fore the need to consolidate society in order to ensure the national security of the country. In this context, the importance of statistics increases, which significantly affects the perception of the dominant values by society, forms the attitude of people to the state policy being pursued. At the same time, the understanding of statistical information (figures, data) in a number of cases does not correspond to reality, making it difficult to adequately assess the existing situation, which is associated with an insufficient level of statistical literacy of the population, officials and specialists in various fields of activity.
Mortgage Lending Market in Modern Russia: a Multidimensional Approach .
Authors: Bakumenko L. P. , Lipatova I. A.
Published: January 2022

The market of one of the most basic participants of the market of housing and communal services – credit organizations is considered. A statistical analysis of mortgage housing lending in Russia was carried out, the classification of the regions of the Russian Federation according to two groups of indicators was carried out: according to the indicators of the housing and communal services market and indicators of the level of socio-economic development of regions by cluster analysis methods and it was shown that not all regions (36 regions) correspond to their levels of groups according to two groups of indicators. The reasons for the development of regions according to the state of development of the housing and communal services market are revealed.
Социальная изоляция как один из рисков пожилых: новая реальность и новые смыслы
Authors: Kornilova M. V.
Published: January 2022

This article is devoted to the study of the consequences of social isolation of elderly Muscovites during the spread of coronavirus infection. The author draws attention to the fact that the informal isolation of the older generation has existed for a long time, but only in the new conditions associated with the pandemic, the «home mode» of life in old age was fixed by law. Social isolation is considered as a risk to the life and health of the older generation. It is shown how unprecedented restrictive measures of the Government affec­ted the psycho-emotional and physical health of elderly people, and the tasks of the state to reduce the vulnerability, ensure the safety and resilience of the elderly were not solved.
Simulação computacional via ATPDraw das alternativas para expansão da capacidade de transmissão de energia elétrica na região de Jaíba e Janaúba em Minas Gerais/ Computational simulation via ATPDraw of alternatives for expanding electricity transmission capacity in the Jaíba and Janaúba region in Minas Gerais
Authors: Sudré Cleiton Rocha , Araújo João Vitor Gomes , Fernandes Júlia Oliveira , Souza Mariana Tainná Silva , Breda Jáder Fernando Dias , Silva Thiago Franchi Pereira da
Published: January 2022

A inserção de fontes de energia alternativas renováveis na matriz elétrica do país se torna cada vez mais presente, tornando-se necessário implantar e potencializar sistemas capazes de explorar todo o potencial elétrico das regiões onde se faz mais presente o uso deste potencial, seja ele eólico, solar ou hídrico. Todavia, para que os sistemas implantados sejam capazes de escoar o máximo de potencial elétrico de uma região, é necessário um período de análises e estudos específicos, com a utilização de critérios também específicos para cada tipo de região utilizada como referência. No caso da região norte do estado de Minas Gerais, ao observar a conexão entre os municípios de Jaíba e Janaúba, nota-se que a subestação Janaúba 3 apresenta problemas para escoamento de potencial elétrico devido a ultrapassagem dos limites de carregamento com a atual quantidade de autotransformadores presentes nesta subestação. A adição do 3° e 4° bancos de autotransformadores nesta subestação foi a solução encontrada para resolver o problema do escoamento. Sendo que, esta solução teve sua eficácia comprovada por meio de simulações realizadas pela Empresa de Pesquisa Energética (EPE) utilizando o programa computacional Anarede, que requer a aquisição de uma licença para uso. No presente trabalho foram replicadas as mesmas simulações, porém utilizando-se o software livre ATPDraw, apresentando resultados plenamente satisfatórios em suas análises, comprovando a eficácia de sua utilização se comparando com os resultados obtidos pelo software Anarede.
Nefrotoxicidade por Anti-Inflamatórios / Anti-InflammatoryNephrotoxicity
Authors: Chaves Luís Fernando Ferreira , Pinto Rafaela Rocha
Published: January 2022

Os anti-inflamatórios não esteroidais (AINEs) fármacos habitualmente utilizados, que constituem uma das categorias de fármacos mais prescritas em todo mundo, são utilizados no tratamento da dor aguda, moderada e crônica decorrente de processo inflamatório e possuem três tipos de ações diferentes: Anti-inflamatória, Analgésica e Antipirética. Eles são relacionados à Nefrotoxicidade, principalmente quando empregues cronicamente. Condições como idade e patologias, que sozinhos já geram à redução na taxa de filtração glomerular, aumentando a probabilidade de Nefrotoxicidade dos AINEs. Tratando-se de uma pesquisa bibliográfica de natureza exploratória, que tem como base o levantamento de dados científicos secundários e a sistematização das informações a partir de bancos de dados como o Scielo, Pubmed e Medline.Tendo por objetivo descrever a categoria terapêutica dos AINEs, ao demonstrar suas propriedades farmacológicas, indicações clínicas e reações adversas; relacionar os riscos mais frequentes associados ao seu uso recorrente e irracional e ressaltar a importância da assistência farmacêutica na seleção e seguimento da terapia. A utilização por um longo período pode levar ao desenvolvimento da doença renal crônica (DRC). Já nos indivíduos saudáveis esse uso não gera grandes prejuízos. No entanto, por possuir um efeito dose-dependente, recomenda-se grande atenção no uso crônico, por fomentar o risco de evoluir para uma nefrotoxicidade.
Use of fruit epicarps to formulate pectin-based bioactive films / Utilização de epicarpos de frutos para formulação de filmes bioativos à base de pectinas
Authors: Júnior Sérgio Dantas de Oliveira , Santos Paula Romenya Gouvea dos , Aguiar Lorena Bentolila de , Nascimento Larissa Batista Brito do , Santos Jocélia Pinheiro , Pessoa Vitor Alves , Campos Ceci Sales- , Chevreuil Larissa Ramos
Published: January 2022

The functional properties of biofilms can vary according to the biopolymer used as the raw material; thus, in the search for alternative sources for preparation of biodegradable films, fruits and vegetables have been used to extract compounds of interest with applications in the food industry. The objective of this work was to obtain and characterize bioactive films based on pectin extracted from the epicarps (skin) of the fruit. The genipap (Genipa americana), red pitaya (Hylocereus polyrhizus) and star fruit (Averrhoa carambola) were collected, washed, pulped and dried at 50 °C for 24 h, and their epicarps were ground and subjected to pectin extraction using the casting method. The films were characterized as to their visual appearance, moisture, pH, water solubility and antioxidant activity. The pectin-based films of G. americana and H. polyrhizus showed a yellowish color, while A. carambola was dark brown. The highest pectin yield (29%) and moisture content (13.9%) were obtained from the H. polyrhizus film, while A. carambola showed the highest solubility in water (98.6%) and had the highest pH (3.9). Additionally, the film based on A. carambola showed greater antioxidant potential against ABTS (30.5%) and DPPH (34%), as well as greater reducing power (0.262 absorbance at 750 nm) and content of total phenolic compounds (553 mg GAE/100 g), whereas H. polyrhizus had a higher percentage of chelating ability (27%). The physicochemical characteristics and bioactive properties exhibited make the film formulation a viable alternative for the food industry.
O papel das instituições de ensino superior no desenvolvimento de soft Skills para a empregabilidade / The role of higher education institutions in the development of soft Skills for employability
Authors: Freitas Gabriel Blanc Costa Vargas , Alvaro Marcos Coelho Silva , Miranda Bianca Sampaio e Melo de , Junior Hamilton Lopes de Miranda
Published: January 2022

O presente artigo visa realizar uma revisão bibliométrica, com o tema “soft skills e empregabilidade”. Neste âmbito, faz-se uma relação entre as elevadas taxas de desemprego no Brasil, a inadequação de postos de trabalho a graduandos atuantes no mercado e o papel das Instituições de Ensino Superior (IES) na melhoria destes números a partir das soft skills. Para a construção deste trabalho, propõem-se uma síntese do estudo feito a partir de 140 artigos relacionados ao tema, presentes na base Scopus, com o auxílio da plataforma EndNote. Através da análise das pesquisas selecionadas, confirma-se que as Instituições de Ensino Superior são uma das responsáveis pelo desenvolvimento das soft skills para empregabilidade. Dessa forma, a pesquisa aponta os responsáveis e diversos meios para esse desenvolvimento, assim como, a necessidade de um alinhamento de expectativas entre IES, governo e mercado para ser possível a redução das taxas de desemprego. Por fim, o tema estudado se apresenta como fundamental para a atuação de graduandos no mercado e diminuição da taxa de desemprego, conclui-se também que o tema deve ser mais estimulado no Brasil visto que, na amostra analisada não há periódicos ou autores brasileiros.
Análisis de intrusiones cibernéticas con el uso del Honeypots. Una revisión sistemática / Análise de invasões cibernéticas usando Honeypots. Uma revisão sistemática
Authors: Macias Henrry Javier Rentería , Márquez Jimmy Fernando Ramírez , Cabrera Carlos Simón Plata , Ruperti Jonathan Patricio Cárdenas , Calero Rómulo Sandino Jurado
Published: January 2022

Honeypot o sistema señuelo diseñado para ser el objetivo de un atacante en las intrusiones cibernéticas además puede recopilar información sobre técnicas y comportamientos de ataque. Se ha realizado una gran cantidad de trabajo en el campo de la detección de intrusiones en la red durante las últimas tres décadas. Con las redes cada vez más rápidas y con la creciente dependencia de Internet tanto a nivel personal como comercial, la detección de intrusos se convierte en un proceso desafiante. El desafío aquí no es solo poder monitorear activamente un gran número de sistemas, sino también poder reaccionar rápidamente a diferentes eventos. Antes de desplegar un honeypot es recomendable tener una idea clara de lo que debe y no debe hacer el honeypot. Debe haber una comprensión clara de los sistemas operativos que se utilizarán y los servicios (como un servidor web, servidor ftp, etc.) que ejecutará un honeypot. Se deben tener en cuenta los riesgos involucrados y se deben comprender los métodos para abordar o reducir estos riesgos. También es recomendable tener un plan sobre qué hacer en caso de que el honeypot se vea comprometido. La presente revisión sistemática aborda el estado actual de la investigación ligada a la detección de intrusiones usando honeypots. La recopilación de información científica se apoyó en el sistema Mendeley, seleccionándose 32 artículos luego de la evaluación de calidad que tuvo como base criterios de inclusión y exclusión previamente establecidos.
La prevención de riesgos laborales y su marco normativo. Una revisión documental / Prevenção de riscos ocupacionais e seu marco regulatório. Uma revisão documental
Authors: Quiñonez Luis Adrián González , Mina Mirna Geraldine Cevallos , Bolaños Karla Roxeyine Realpe , Vega Roxana Jasmine Santillán , Vera Carlos Humberto Reyes
Published: January 2022

El objetivo de esta investigación fue analizar la prevención de riesgos laborales y su marco normativo bajo una visión prospectiva de los derechos humanos. Se ha realizado un estudio crítico de las diferentes situaciones de riesgo a las que se exponen los trabajadores en los lugares donde cumplen sus labores y el marco normativo que los ampara en materia de derechos humanos. Este estudio siguió los lineamientos del enfoque cuantitativo, bajo el paradigma positivista y constituye una investigación documental–descriptiva, razón por la cual, para el abordaje de la información, se utilizó como técnica el análisis de contenidos y como instrumento se empleó una hoja de registro, aplicado a los diferentes documentos. Como resultados se tiene que, en el Ecuador se reconoce el derecho al trabajo y se garantiza el derecho a la salud de los trabajadores en caso de accidentes laborales en concordancia con las leyes de la república y de los convenios y normativas internacionales. Se concluye que, el estado a través de sus leyes y normativas, promueve espacios de trabajo dignos que minimicen riesgos y por consiguiente eviten afectaciones de la salud física y mental de los trabajadores de manera que logren su desarrollo pleno, el de las empresas e instituciones y el de la nación.
As dificuldades enfrentadas pelo portador de ostomia de eliminação intestinal na sexualidade e as implicações para a atuação da enfermagem / The difficulties faced by the intestine disposal ostomy patient in sexuality and the implications for the performance of nursing
Authors: Santos Júlio César , Viana Janayna Araújo , Silva Arannadia Barbosa , Oliveira Iraciane Rodrigues Nascimento , Soares Mariana Reis , Murada Sabrynna Gabryela Rocha , Pinho Michelle Dhemensa Monteiro de , Araújo Mateus Noleto
Published: January 2022

Objetivo Conhecer as dificuldades sentidas e/ou enfrentadas pelo portador de ostomia de eliminação intestinal na sexualidade e as implicações para a atuação da enfermagem. Método Trata se de uma revisão da literatura do tipo Revisão Integrativa realizada nas bases de dados: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Scientific Eletronic Library Online (SCIELO), Banco de dados em Enfermagem (BDENF), Portal de Periódicos da CAPES e National Library of Medicine National Institutesof Health (PUBMED). Foi utilizado o operador booleano AND e os descritores ostomia, sexualidade, assistência de enfermagem e ostomia intestinal. Foram selecionados 16 artigos para análise do estudo. Resultados. Os ostomizados enfrentam dificuldades na sua sexualidade, de origem emocionais e fisiológicas como medos e receios de rejeição do parceiro, de mostrar o corpo, de lesionar a ostomia, de contar sobre sua nova condição e de passar por constrangimento causado pela bolsa; disfunção erétil, distúrbio ejaculatório, perda da elasticidade vaginal, dispareunia, redução da lubrificação e dificuldade de chegar ao orgasmo. Considerações finais Portanto, sugere-se uma maior intensificação das políticas públicas em saúde em educação permanente que proporcione aos enfermeiros e demais profissionais de saúde acerca do cuidado com o paciente ostomizado de forma holística, voltada para a condição clínica e reabilitação, incluindo o cuidado na saúde sexual e auto - realização pessoal destes pacientes.
Autotransplante dentário: revisão da literature / Dental autotransplantation: literature review
Authors: Almeida Dayanna Stefani C , Gama Fidel carloan Castro , Rodrigues Paloma Gomes , De Oliveira Juliana Maria Souza
Published: January 2022

O autotransplante dentário autógeno é a remoção e transferência de um dente com vitalidade do seu sítio de origem para outro local com a finalidade de repor um dente ausente ou perdido, sendo que este elemento dentário é doado pelo próprio indivíduo. Sendo assim, este estudo teve como objetivo realizar uma revisão de literatura sobre o autotransplante dentário, abordando as vantagens deste, as principais técnicas cirúrgicas e quais os fatores que influenciam no seu sucesso clínico. A metodologia da revisão de literatura contou com a busca de artigos científicos a respeito da temática nas plataforma on line SciELO e PubMed, publicados integralmente em língua portuguesa ou inglesa entre os anos de 2016 à 2021. Os principais achados revelam que o transplante dentário autógeno é uma opção adequada para reposições dentárias em pacientes jovens, pois devolve as características funcionais e estéticas de forma segura e conservadora. E por fim, para o sucesso clínico é muito importante um planejamento cirúrgico adequado, a idade do paciente, anatomia e condições do elemento dentário doador e do sítio receptor e habilidade do cirurgião-dentista.
Uso Quetiapina no tratamento da Esquizofrenia: Revisão da literatura / Use Quetiapine in the treatment of Schizophrenia: Literature review
Authors: Filho Francisco Fernandes da Silva , Campos João Soares , Ramos Denny Vitor Barbosa
Published: January 2022

A esquizofrenia é transtorno mental cujo os sintomas levam a classificação dos pacientes acometidos. A partir da farmacoterapia de primeira geração, os pacientes apresentaram a melhoria na qualidade de vida devido a redução dos sintomas, mas a recorrência hospitalar e os efeitos colaterais, levam a dificuldade na adesão ao tratamento e/ou abandono ao tratamento. Dentre os fármacos de segunda geração, encontra-se a Quetiapina que pertence à classe dos Dibenzotiazepina de ação farmacológica atípica. O objetivo desta pesquisa é descrever o emprego da Quetiapina no tratamento da esquizofrenia apresentando as melhorias proporcionadas na qualidade de vida dos pacientes através de revisão bibliográfica. Com o desenvolvimento dos antipsicóticos atípico de segunda geração, a Quetiapina apresenta-se como eficaz no tratamento tanto nos sintomas positivos como negativos da esquizofrenia, reduzindo o tempo de internação hospitalar dos pacientes, possibilitando a melhoria qualidade de vida para portadores devido ao retorno do convívio social, tendo efeitos colaterais mínimos principalmente frente aos sintomas extrapiramidais, porém o uso deste fármaco está relacionado ao aumento de peso dos pacientes visto possíveis as variações metabólicas causadas pelo uso de longo prazo.