bluuebunny/crossref_metadata_2025 huggingface dataset:
Estimating Invasion Success by Non-Native Trees in a National Park Combining WorldView-2 Very High Resolution Satellite Data and Species Distribution Models
Authors: Monteiro Antonio , Gonçalves João , Fernandes Rui , Alves Susana , Marcos Bruno , Lucas Richard , Teodoro Ana , Honrado João
Published: January 2017

Invasion by non-native tree species is an environmental and societal challenge requiring predictive tools to assess invasion dynamics. The frequent scale mismatch between such tools and on-ground conservation is currently limiting invasion management. This study aimed to reduce these scale mismatches, assess the success of non-native tree invasion and determine the environmental factors associated to it. A hierarchical scaling approach combining species distribution models (SDMs) and satellite mapping at very high resolution (VHR) was developed to assess invasion by Acacia dealbata in Peneda-Gerês National Park, the only national park in Portugal. SDMs were first used to predict the climatically suitable areas for A. dealdata and satellite mapping with the random-forests classifier was then applied to WorldView-2 very-high resolution imagery to determine whether A. dealdata had actually colonized the predicted areas (invasion success). Environmental attributes (topographic, disturbance and canopy-related) differing between invaded and non-invaded vegetated areas were then analyzed. The SDM results indicated that most (67%) of the study area was climatically suitable for A. dealbata invasion. The onset of invasion was documented to 1905 and satellite mapping highlighted that 12.6% of study area was colonized. However, this species had only colonized 62.5% of the maximum potential range, although was registered within 55.6% of grid cells that were considerable unsuitable. Across these areas, the specific success rate of invasion was mostly below 40%, indicating that A. dealbata invasion was not dominant and effective management may still be possible. Environmental attributes related to topography (slope), canopy (normalized difference vegetation index (ndvi), land surface albedo) and disturbance (historical burnt area) differed between invaded and non-invaded vegetated area, suggesting that landscape attributes may alter at specific locations with Acacia invasion. Fine-scale spatial-explicit estimation of invasion success combining SDM predictions with VHR invasion mapping allowed the scale mismatch between predictions of invasion dynamics and on-ground conservation decision making for invasion management to be reduced. Locations with greater potential to suppress invasions could also be defined. Uncertainty in the invasion mapping needs to be accounted for in the interpretation of the results.
Learning Parsimonious Classification Rules from Gene Expression Data Using Bayesian Networks with Local Structure
Authors: Lustgarten Jonathan , Balasubramanian Jeya , Visweswaran Shyam , Gopalakrishnan Vanathi
Published: January 2017

The comprehensibility of good predictive models learned from high-dimensional gene expression data is attractive because it can lead to biomarker discovery. Several good classifiers provide comparable predictive performance but differ in their abilities to summarize the observed data. We extend a Bayesian Rule Learning (BRL-GSS) algorithm, previously shown to be a significantly better predictor than other classical approaches in this domain. It searches a space of Bayesian networks using a decision tree representation of its parameters with global constraints, and infers a set of IF-THEN rules. The number of parameters and therefore the number of rules are combinatorial in the number of predictor variables in the model. We relax these global constraints to learn a more expressive local structure with BRL-LSS. BRL-LSS entails a more parsimonious set of rules because it does not have to generate all combinatorial rules. The search space of local structures is much richer than the space of global structures. We design the BRL-LSS with the same worst-case time-complexity as BRL-GSS while exploring a richer and more complex model space. We measure predictive performance using Area Under the ROC curve (AUC) and Accuracy. We measure model parsimony performance by noting the average number of rules and variables needed to describe the observed data. We evaluate the predictive and parsimony performance of BRL-GSS, BRL-LSS and the state-of-the-art C4.5 decision tree algorithm, across 10-fold cross-validation using ten microarray gene-expression diagnostic datasets. In these experiments, we observe that BRL-LSS is similar to BRL-GSS in terms of predictive performance, while generating a much more parsimonious set of rules to explain the same observed data. BRL-LSS also needs fewer variables than C4.5 to explain the data with similar predictive performance. We also conduct a feasibility study to demonstrate the general applicability of our BRL methods on the newer RNA sequencing gene-expression data.
Impact of Ambient Conditions of Arab Gulf Countries on the Performance of Gas Turbines Using Energy and Exergy Analysis
Authors: Baakeem Saleh , Orfi Jamel , Alaqel Shaker , Al-Ansary Hany
Published: January 2017

In this paper, energy and exergy analysis of typical gas turbines is performed using average hourly temperature and relative humidity for selected Gulf cities located in Saudi Arabia, Kuwait, United Arab Emirates, Oman, Bahrain and Qatar. A typical gas turbine unit of 42 MW is considered in this study. The electricity production, thermal efficiency, fuel consumption differences between the ISO conditions and actual conditions are determined for each city. The exergy efficiency and exergy destruction rates for the gas turbine unit and its components are also evaluated taking ISO conditions as reference conditions. The results indicate that the electricity production losses occur in all cities during the year, except in Dammam and Kuwait for the period between November and March. During a typical day, the variation of the power production can reach 4 MW. The rate of exergy destruction under the combined effect of temperature and humidity is significant in hot months reaching a maximum of 12 MW in July. The presented results show also that adding inlet cooling systems to the existing gas turbine units could be justified in hot periods. Other aspects, such as the economic and environmental ones, should also be investigated.
Exploitation of the Maximum Entropy Principle in Mathematical Modeling of Charge Transport in Semiconductors
Authors: Mascali Giovanni , Romano Vittorio
Published: January 2017

In the last two decades, the Maximum Entropy Principle (MEP) has been successfully employed to construct macroscopic models able to describe the charge and heat transport in semiconductor devices. These models are obtained, starting from the Boltzmann transport equations, for the charge and the phonon distribution functions, by taking—as macroscopic variables—suitable moments of the distributions and exploiting MEP in order to close the evolution equations for the chosen moments. Important results have also been obtained for the description of charge transport in devices made both of elemental and compound semiconductors, in cases where charge confinement is present and the carrier flow is two- or one-dimensional.
Evaluation Model of Aluminum Alloy Welded Joint Low-Cycle Fatigue Data Based on Information Entropy
Authors: Liu Yaliang , Zou Li , Sun Yibo , Yang Xinhua
Published: January 2017

An evaluation model of aluminum alloy welded joint low-cycle fatigue data based on information entropy is proposed. Through calculating and analyzing the information entropy of decision attributes, quantitative contribution of stress concentration, plate thickness, and loading mode to the fatigue destruction are researched. Results reveal that the total information entropy of the fatigue data based on nominal stress, structural stress and equivalent structural stress are, respectively, 0.9702, 0.8881, and 0.8294. There is consistency between the reducing trend of the weight-based information entropy and the smaller and smaller standard deviation of the S-N curves. In the structural stress based S-N curve, total stress concentration factor is crucial for the distribution of the fatigue data and the weight based information entropy of membrane stress concentration factor is 0.6754, which illustrates that stress concentration is a key issue of welded structure to which ought to be attached great importance. Subsequently, in the equivalent structural stress-based S-N curve, the weight based information entropy of stress ratio is 0.5759, which plays an important role in the distribution of fatigue data. With the importance level of the attributes on the S-N curves investigated, the correction of R in the equivalent structural stress based master S-N curve method should be carried out to make the welding fatigue prediction much more accurate.
Distributed Rateless Codes with Unequal Error Protection Property for Space Information Networks
Authors: Jiao Jian , Yang Yi , Feng Bowen , Wu Shaohua , Li Yonghui , Zhang Qinyu
Published: January 2017

In this paper, we propose a novel distributed unequal error protection (UEP) rateless coding scheme (DURC) for space information networks (SIN). We consider the multimedia data transmissions in a dual-hop SIN communication scenario, where multiple disjoint source nodes need to transmit their UEP rateless coded data to a destination via a dynamic relay. We formulate the optimization problems to provide optimal degree distributions on the direct links and the dynamic relay links to satisfy the required error protection levels. The optimization methods are based on the And–Or tree analysis and can be solved by multi-objective programming. In addition, we evaluate the performance of the optimal DURC scheme, and simulation results show that the proposed DURC scheme can effectively provide UEP property under a variety of error requirements.
Acknowledgement to Reviewers of Energies in 2016
Authors:   Energies Editorial Office
Published: January 2017

The editors of Energies would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2016.[...]
Evaluating the Degradation Mechanism and State of Health of LiFePO4 Lithium-Ion Batteries in Real-World Plug-in Hybrid Electric Vehicles Application for Different Ageing Paths
Authors: Zhang Chi , Yan Fuwu , Du Changqing , Kang Jianqiang , Turkson Richard
Published: January 2017

Accurate determination of the performance and precise prediction of the state of health (SOH) of lithium-ion batteries are necessary to ensure reliability and efficiency in real-world application. However, most SOH offline studies were based on dynamic stress tests, which only reflect the universal rule of degradation, but are not necessarily applicable for real-world applications. This paper presents an experimental evaluation of two different operations of real-world plug-in hybrid electric vehicles with LiFePO4 batteries as energy-storage systems. First, the LiFePO4 batteries were subjected to a set of comparative experimental tests that consider the effects of charge depleting (CD) and charge sustaining (CS) operations. Then, different voltage analysis along with the close-to-equilibrium open circle voltage was utilized to evaluate the performance of the batteries in life cycles. Finally, a qualitative relationship between the external factors (the percentage of time of CD/CS operations during the entire driving range) and the degradation mechanism was built with the help of the proposed methods. Results indicated that the external factors affect the degree of the batteries degradation, but not up to the point when the capacity fading stage occurs. This relationship contributes to the foundation for plug-in hybrid electric vehicles’ (PHEVs’) energy management strategy or battery management system control strategy.
Exploring the Feasibility of Low-Carbon Scenarios Using Historical Energy Transitions Analysis
Authors: Napp Tamaryn , Bernie Dan , Thomas Rebecca , Lowe Jason , Hawkes Adam , Gambhir Ajay
Published: January 2017

The scenarios generated by energy systems models provide a picture of the range of possible pathways to a low-carbon future. However, in order to be truly useful, these scenarios should not only be possible but also plausible. In this paper, we have used lessons from historical energy transitions to create a set of diagnostic tests to assess the feasibility of an example 2 °C scenario (generated using the least cost optimization model, TIAM-Grantham). The key assessment criteria included the rate of deployment of low carbon technologies and the rate of transition between primary energy resources. The rates of deployment of key low-carbon technologies were found to exceed the maximum historically observed rate of deployment of 20% per annum. When constraints were added to limit the scenario to within historically observed rates of change, the model no longer solved for 2 °C. Under these constraints, the lowest median 2100 temperature change for which a solution was found was about 2.1 °C and at more than double the cumulative cost of the unconstrained scenario. The analysis in this paper highlights the considerable challenge of meeting 2 °C, requiring rates of energy supply technology deployment and rates of declines in fossil fuels which are unprecedented.
Towards Nearly Zero Energy Buildings in Europe: A Focus on Retrofit in Non-Residential Buildings
Authors: D’Agostino Delia , Zangheri Paolo , Castellazzi Luca
Published: January 2017

Buildings are the focus of European (EU) policies aimed at a sustainable and competitive low-carbon economy by 2020. Reducing energy consumption of existing buildings and achieving nearly zero energy buildings (NZEBs) are the core of the Energy Efficiency Directive (EED) and the recast of the Energy Performance of Building Directive (EPBD). To comply with these requirements, Member States have to adopt actions to exploit energy savings from the building sector. This paper describes the differences between deep, major and NZEB renovation and then it provides an overview of best practice policies and measures to target retrofit and investment related to non-residential buildings. Energy requirements defined by Member States for NZEB levels are reported comparing both new and existing residential and non-residential buildings. The paper shows how the attention given to refurbishment of NZEBs increased over the last decade, but the achievement of a comprehensive implementation of retrofit remains one of main challenges that Europe is facing.
The Use of Auxin Quantification for Understanding Clonal Tree Propagation
Authors: Stuepp Carlos , Wendling Ivar , Trueman Stephen , Koehler Henrique , Zuffellato-Ribas Katia
Published: January 2017

Qualitative and quantitative hormone analyses have been essential for understanding the metabolic, physiological, and morphological processes that are influenced by plant hormones. Auxins are key hormones in the control of many aspects of plant growth and development and their endogenous levels are considered critical in the process of adventitious root induction. Exogenous auxins are used extensively in the clonal propagation of tree species by cuttings or tissue culture. Understanding of auxin effects has advanced with the development of increasingly accurate methods for auxin quantification. However, auxin analysis has been challenging because auxins typically occur at low concentrations, while compounds that interfere with their detection often occur at high concentrations, in plant tissues. Interference from other compounds has been addressed by extensive purification of plant extracts prior to auxin analysis, although this means that quantification methods have been limited by their expense. This review explores the extraction, purification, and quantification of auxins and the application of these techniques in developing improved methods for the clonal propagation of forestry trees.
What Is Genealogy? An Anthropological/Philosophical Reconsideration
Authors: Knauft Bruce
Published: January 2017

Genealogical analysis in the present begs reconsideration of Nietzschean and Foucauldian precursors in relation to the ethical subject position of the subject, on the one hand, and application to concrete contexts of lineal connection asserted diversely across cultural time and space, on the other. This paper considers how the relation between genealogy and history has emerged in anthropologically relevant ways since Foucault, including comparisons and contrasts with selected recent philosophical treatments, with implications for contemporary understandings of subversion, resistance, and the critical assessment of truth claims, including concerning veridiction itself. Developments in anthropology resonate with many features associated with genealogical analysis in Foucault’s latter works. In selected respects, the subversive process of problematizing received accounts of historical and cultural development articulates with the subversive process of ethnographic investigation, whereby received Western or other assumptions are defamiliarized by being thrown into contrastive cultural relief. The more general relation between genealogical analysis and the critical understanding of modernity is discussed, including in relation to contemporary political genealogy and ‘inter-genealogical’ analysis.
Self-Reported Snoring Is Associated with Dyslipidemia, High Total Cholesterol, and High Low-Density Lipoprotein Cholesterol in Obesity: A Cross-Sectional Study from a Rural Area of China
Authors: Zhang Naijin , Chen Yintao , Chen Shuang , Jia Pengyu , Guo Xiaofan , Sun Guozhe , Sun Yingxian
Published: January 2017

Studies to explore the relationship between self-reported snoring and dyslipidemia, especially high total cholesterol (TC) and high low-density lipoprotein cholesterol (LDL-C), in the general population are still lacking. Our study was designed to examine whether self-reported snoring is significantly associated with dyslipidemia and ascertain the effects of different snoring intensities on dyslipidemia. There were 10,139 participants in our study. After adjustment for all confounding factors, self-reported snoring (OR = 1.207; p = 0.003), moderate (OR = 1.229; p = 0.015), strong (OR = 1.222; p = 0.033), and very strong (OR = 1.467; p = 0.012) snoring intensity, but not low (OR = 1.110; p = 0.224) snoring intensity, were significantly associated with dyslipidemia among adults with BMI (body mass index) ≥ 25 kg/m2. In addition, self-reported snoring was significantly associated with high TC (OR = 1.167; p = 0.048) and high LDL-C (OR = 1.228; p = 0.044), rather than low HDL-C (OR = 1.171; p = 0.057) and high triglyceride (TG) (OR = 1.110; p = 0.141). In conclusion, adults with BMI ≥ 25 kg/m2 and who experience snoring, especially moderate, strong, and very strong intensity levels of snoring, should be on the alert regarding the possibility of dyslipidemia, especially high LDL-C and high TC.
Comparison of Gastric versus Gastrointestinal PBET Extractions for Estimating Oral Bioaccessibility of Metals in House Dust
Authors: Boros Kristina , Fortin Danielle , Jayawardene Innocent , Chénier Marc , Levesque Christine , Rasmussen Pat
Published: January 2017

Oral bioaccessibility estimates for six metals which are prevalent as contaminants in Canada (zinc, lead, cadmium, copper, nickel, and chromium) are investigated for house dust using the simple gastric phase versus the two-phase physiologically-based extraction technique (PBET). The purpose is to determine whether a complete gastrointestinal (GI) assay yields a more conservative (i.e., higher) estimate of metal bioaccessibility in house dust than the gastric phase alone (G-alone). The study samples include household vacuum dust collected from 33 homes in Montreal, Canada, plus four certified reference materials (NIST 2583, NIST 2584, NIST 2710 and NIST 2710a). Results indicate that percent bioaccessibilities obtained using G-alone are generally greater than or equivalent to those obtained using the complete GI simulation for the six studied metals in house dust. Median bioaccessibilities for G-alone/GI in household vacuum dust samples (n = 33) are 76.9%/19.5% for zinc, 50.4%/6.2% for lead, 70.0%/22.4% for cadmium, 33.9%/30.5% for copper and 28.5%/20.7% for nickel. Bioaccessible chromium is above the detection limit in only four out of 33 samples, for which G-alone results are not significantly different from GI results (p = 0.39). It is concluded that, for the six studied metals, a simple G-alone extraction provides a conservative and cost-effective approach for estimating oral bioaccessibility of metals in house dust.
Genetic Aspects of Susceptibility to Mercury Toxicity: An Overview
Authors: Andreoli Virginia , Sprovieri Francesca
Published: January 2017

Human exposure to mercury is still a major public health concern. In this context, children have a higher susceptibility to adverse neurological mercury effects, compared to adults with similar exposures. Moreover, there exists a marked variability of personal response to detrimental mercury action, in particular among population groups with significant mercury exposure. New scientific evidence on genetic backgrounds has raised the issue of whether candidate susceptibility genes can make certain individuals more or less vulnerable to mercury toxicity. In this review, the aim is to evaluate a new genetic dimension and its involvement in mercury risk assessment, focusing on the important role played by relevant polymorphisms, located in attractive gene targets for mercury toxicity. Existing original articles on epidemiologic research which report a direct link between the genetic basis of personal vulnerability and different mercury repercussions on human health will be reviewed. Based on this evidence, a careful evaluation of the significant markers of susceptibility will be suggested, in order to obtain a powerful positive “feedback” to improve the quality of life. Large consortia of studies with clear phenotypic assessments will help clarify the “window of susceptibility” in the human health risks due to mercury exposure.
SSIEGNOS: A New Asian Single Site Tropospheric Correction Model
Authors: Huang Liangke , Xie Shaofeng , Liu Lilong , Li Junyu , Chen Jun , Kang Chuanli
Published: January 2017

This paper proposes a new Asian single site tropospheric correction model called the Single Site Improved European Geostationary Navigation Overlay Service model (SSIEGNOS) by refining the European Geostationary Navigation Overlay Service (EGNOS) model at a single site. The performance of the SSIEGNOS model is analyzed. The results show that (1) the bias and root mean square (RMS) error of zenith tropospheric delay (ZTD) calculated from the EGNOS model are 0.12 cm and 5.87 cm, respectively; whereas those of the SSIEGNOS model are 0 cm and 2.52 cm, respectively. (2) The bias and RMS error show seasonal variation in the EGNOS model; however, little seasonal variation is observed in the SSIEGNOS model. (3) The RMS error decreases with increasing altitude or latitude in the two models; however, no such relationships were found in the bias. In addition, the annual predicted bias and RMS error in Asia are −0.08 cm and 3.14 cm for the SSIEGNOS model, respectively; however, the EGNOS and UNB3m (University of New Brunswick) models show comparable predicted results. Relative to the EGNOS model, the annual predicted bias and RMS error decreased by 55% and 48%, respectively, for the SSIEGNOS model.
Recent Advances in Phospholipids from Colostrum, Milk and Dairy By-Products
Authors: Verardo Vito , Gómez-Caravaca Ana , Arráez-Román David , Hettinga Kasper
Published: January 2017

Milk is one of the most important foods for mammals, because it is the first form of feed providing energy, nutrients and immunological factors. In the last few years, milk lipids have attracted the attention of researchers due to the presence of several bioactive components in the lipid fraction. The lipid fraction of milk and dairy products contains several components of nutritional significance, such as ω-3 and ω-6 polyunsaturated fatty acids, CLA, short chain fatty acids, gangliosides and phospholipids. Prospective cohort evidence has shown that phospholipids play an important role in the human diet and reinforce the possible relationship between their consumption and prevention of several chronic diseases. Because of these potential benefits of phospholipids in the human diet, this review is focused on the recent advances in phospholipids from colostrum, milk and dairy by-products. Phospholipid composition, its main determination methods and the health activities of these compounds will be addressed.
Glycative Stress and Its Defense Machinery Glyoxalase 1 in Renal Pathogenesis
Authors: Hirakawa Yosuke , Inagi Reiko
Published: January 2017

Chronic kidney disease is a major public health problem around the world. Because the kidney plays a role in reducing glycative stress, renal dysfunction results in increased glycative stress. In turn, glycative stress, especially that due to advanced glycated end products (AGEs) and their precursors such as reactive carbonyl compounds, exacerbates chronic kidney disease and is related to premature aging in chronic kidney disease, whether caused by diabetes mellitus or otherwise. Factors which hinder a sufficient reduction in glycative stress include the inhibition of anti-glycation enzymes (e.g., GLO-1), as well as pathogenically activated endoplasmic reticulum (ER) stress and hypoxia in the kidney. Promising strategies aimed at halting the vicious cycle between chronic kidney disease and increases in glycative stress include the suppression of AGE accumulation in the body and the enhancement of GLO-1 to strengthen the host defense machinery against glycative stress.
Independent Effects of a Herbivore’s Bacterial Symbionts on Its Performance and Induced Plant Defences
Authors: Staudacher Heike , Schimmel Bernardus , Lamers Mart , Wybouw Nicky , Groot Astrid , Kant Merijn
Published: January 2017

It is well known that microbial pathogens and herbivores elicit defence responses in plants. Moreover, microorganisms associated with herbivores, such as bacteria or viruses, can modulate the plant’s response to herbivores. Herbivorous spider mites can harbour different species of bacterial symbionts and exert a broad range of effects on host-plant defences. Hence, we tested the extent to which such symbionts affect the plant’s defences induced by their mite host and assessed if this translates into changes in plant resistance. We assessed the bacterial communities of two strains of the common mite pest Tetranychus urticae. We found that these strains harboured distinct symbiotic bacteria and removed these using antibiotics. Subsequently, we tested to which extent mites with and without symbiotic bacteria induce plant defences in terms of phytohormone accumulation and defence gene expression, and assessed mite oviposition and survival as a measure for plant resistance. We observed that the absence/presence of these bacteria altered distinct plant defence parameters and affected mite performance but we did not find indications for a causal link between the two. We argue that although bacteria-related effects on host-induced plant defences may occur, these do not necessarily affect plant resistance concomitantly.
Neuroprotection by Caffeine in Hyperoxia-Induced Neonatal Brain Injury
Authors: Endesfelder Stefanie , Weichelt Ulrike , Strauß Evelyn , Schlör Anja , Sifringer Marco , Scheuer Till , Bührer Christoph , Schmitz Thomas
Published: January 2017

Sequelae of prematurity triggered by oxidative stress and free radical-mediated tissue damage have coined the term “oxygen radical disease of prematurity”. Caffeine, a potent free radical scavenger and adenosine receptor antagonist, reduces rates of brain damage in preterm infants. In the present study, we investigated the effects of caffeine on oxidative stress markers, anti-oxidative response, inflammation, redox-sensitive transcription factors, apoptosis, and extracellular matrix following the induction of hyperoxia in neonatal rats. The brain of a rat pups at postnatal Day 6 (P6) corresponds to that of a human fetal brain at 28–32 weeks gestation and the neonatal rat is an ideal model in which to investigate effects of oxidative stress and neuroprotection of caffeine on the developing brain. Six-day-old Wistar rats were pre-treated with caffeine and exposed to 80% oxygen for 24 and 48 h. Caffeine reduced oxidative stress marker (heme oxygenase-1, lipid peroxidation, hydrogen peroxide, and glutamate-cysteine ligase catalytic subunit (GCLC)), promoted anti-oxidative response (superoxide dismutase, peroxiredoxin 1, and sulfiredoxin 1), down-regulated pro-inflammatory cytokines, modulated redox-sensitive transcription factor expression (Nrf2/Keap1, and NFκB), reduced pro-apoptotic effectors (poly (ADP-ribose) polymerase-1 (PARP-1), apoptosis inducing factor (AIF), and caspase-3), and diminished extracellular matrix degeneration (matrix metalloproteinases (MMP) 2, and inhibitor of metalloproteinase (TIMP) 1/2). Our study affirms that caffeine is a pleiotropic neuroprotective drug in the developing brain due to its anti-oxidant, anti-inflammatory, and anti-apoptotic properties.
Extract of Polygala tenuifolia Alleviates Stress-Exacerbated Atopy-Like Skin Dermatitis through the Modulation of Protein Kinase A and p38 Mitogen-Activated Protein Kinase Signaling Pathway
Authors: Sur Bongjun , Lee Bombi , Yoon Ye , Lim Pooreum , Hong Riwon , Yeom Mijung , Lee Hyang , Park Hijoon , Shim Insop , Lee Hyejung , Jang Young , Hahm Dae-Hyun
Published: January 2017

Atopic dermatitis (AD) and stress create a vicious cycle: stress exacerbates atopic symptoms, and atopic disease elicits stress and anxiety. Targeting multiple pathways including stress and allergic inflammation is, therefore, important for treating AD. In this study, we investigated the remedial value of Polygala tenuifolia Willd. (PTW) for treating immobilization (IMO) stress-exacerbated atopy-like skin dermatitis and its underlying mechanism. Trimellitic anhydride (TMA) was applied to dorsal skin for sensitization and subsequently both ears for eliciting T-cell-dependent contact hypersensitivity in mice, which underwent 2 h-IMO stress and PTW administration for the latter 6 and 9 days in the ear exposure period of TMA, respectively. To elicit in vitro degranulation of human mast cell line-1 (HMC-1), 10 µM substance P (SP) and 200 nM corticotrophin-releasing factor (CRF) were sequentially added with 48 h-interval. PTW extract (500 µg/mL) was added 30 min before CRF treatment. IMO stress exacerbated TMA-induced scratching behavior by 252%, and increased their blood corticosterone levels by two-fold. Treatment with 250 mg/kg PTW significantly restored IMO stress-exacerbated scratching behavior and other indicators such as skin inflammation and water content, lymph node weights, and serum histamine and immunoglobulin E (lgE) levels. Furthermore, it also reversed TMA-stimulated expression of tumor necrosis factor (TNF)-α and interleukin (IL)-4 mRNAs in ear tissues. PTW significantly inhibited SP/CRF-stimulated degranulation of HMC-1 cells, subsequent tryptase secretion, and protein kinase A (PKA) activity. PTW also selectively inhibited p38 mitogen-activated protein kinase (MAPK) phosphorylation in SP/CRF-treated HMC-1 cells. PTW significantly inhibited HMC-1 cell degranulation and alleviated IMO stress-exacerbated atopic dermatitis symptoms by modulating the PKA/p38 MAPK signaling pathway.
MicroRNA-29a Alleviates Bile Duct Ligation Exacerbation of Hepatic Fibrosis in Mice through Epigenetic Control of Methyltransferases
Authors: Yang Ya-Ling , Wang Feng-Sheng , Li Sung-Chou , Tiao Mao-Meng , Huang Ying-Hsien
Published: January 2017

MicroRNA-29 (miR-29) is found to modulate hepatic stellate cells’ (HSCs) activation and, thereby, reduces liver fibrosis pathogenesis. Histone methyltransferase regulation of epigenetic reactions reportedly participates in hepatic fibrosis. This study is undertaken to investigate the miR-29a regulation of the methyltransferase signaling and epigenetic program in hepatic fibrosis progression. miR-29a transgenic mice (miR-29aTg mice) and wild-type littermates were subjected to bile duct-ligation (BDL) to develop cholestatic liver fibrosis. Primary HSCs were transfected with a miR-29a mimic and antisense inhibitor. Profibrogenic gene expression, histone methyltransferases and global genetic methylation were probed with real-time quantitative RT-PCR, immunohistochemical stain, Western blot and ELISA. Hepatic tissue in miR-29aTg mice displayed weak fibrotic matrix as evidenced by Sirius Red staining concomitant with low fibrotic matrix collagen 1α1 expression within affected tissues compared to the wild-type mice. miR-29a overexpression reduced the BDL exaggeration of methyltransferases, DNMT1, DNMT3b and SET domain containing 1A (SET1A) expression. It also elevated phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling within liver tissue. In vitro, miR-29a mimic transfection lowered collagen 1α1, DNMT1, DNMT3b and SET1A expression in HSCs. Gain of miR-29a signaling resulted in DNA hypomethylation and high PTEN expression. This study shines a new light on miR-29a inhibition of methyltransferase, a protective effect to maintain the DNA hypomethylation state that decreases fibrogenic activities in HSC. These robust analyses also highlight the miR-29a regulation of epigenetic actions to ameliorate excessive fibrosis during cholestatic liver fibrosis development.
Seasonal Effects on the Population, Morphology and Reproductive Behavior of Narnia femorata (Hemiptera: Coreidae)
Authors: Cirino Lauren , Miller Christine
Published: January 2017

Many insects are influenced by the phenology of their host plants. In North Central Florida, Narnia femorata (Hemiptera: Coreidae) spends its entire life cycle living and feeding on Opuntia mesacantha ssp. lata. This cactus begins producing flower buds in April that lead to unripe green fruit in June that ripen into red fruit through December. Many morphological and behavioral characteristics of N. femorata are known to be affected by cactus phenology in a controlled laboratory setting, including the degree of sexual dimorphism and mating behavior. Our goal with this study was to determine if similar phenotypic changes of N. femorata occurred over time in the wild, and the extent to which these changes were concordant with phenological changes in its host plant. Further, we investigate the length of the insect mouthparts (beak) over time. Ongoing work has suggested that beak length may change across cohorts of developing insects in response to feeding deep within cactus fruit where seed and pulp depth decrease as the fruit ripens. Our results revealed a drop in cactus fruit abundance between the months of July through October 2015 as cactus fruits turned red and ripened. Simultaneously, the average body size of both males and females of N. femorata declined at two sampled sites. Male hind femora (a sexually-selected weapon) decreased disproportionately in size over time so that males later in the year had relatively smaller hind femora for their body size. The sex-specific patterns of morphological change led to increased sexual-size dimorphism and decreased sexual dimorphism for hind femora later in the year. Further, we found that beak length decreased across cohorts of insects as cactus fruit ripened, suggesting phenotypic plasticity in mouthpart length. Behavioral studies revealed that female readiness to mate increased as the season progressed. In sum, we found pronounced changes in the phenotypes of these insects in the field. Although this study is far from comprehensive, it provides tantalizing patterns that suggest many directions for future research.
Ergonomics of Prehensility in Pushing and Pulling Motions: An Anatomical and Biomechanical Overview
Authors: Szychlinska Marta , Dullaert Koen , Beumer Annechien , Nsir Houda , Guglielmino Claudia , Mazzone Venera , Giunta Salvatore
Published: January 2017

The hand represents one of the most remarkable expressions of humanization of the anterior limb. The anterior limb, at first ambulatory, underwent continuous evolution acquiring innumerable new functions. In the course of human evolution the hand has undergone continual structural and functional adaptations, characterized, among others, by enrichment of peripheral innervation and further development of the thumb. This development was accompanied by important changes in the brain and the relocation of the eyes, together allowing the muscle control and stereoscopic vision, necessary for a controlled grip. The anatomy of the hand is complex, intricate, and fascinating. Its integrity is absolutely essential for our everyday functional living. It is intimately correlated with the brain, both in the evolution of the species and in the development of the individual. Actually, we can state that we “think” and “feel” with our hands, hence, their contribution is essential to the mental processes of thought and feeling. The aim of this review is to evaluate the most typical hand quality, the prehensility and hence, the possibility of manoeuvring tools. Our attention is mainly focused on the hand anatomy and prehensility during pushing and pulling motions. In particular, our attention is directed toward the relationship existing between the hand prehensility and the volume of the object to be gripped. As an example, we use a grip of the paddle and, pushing and pulling motions during kayak paddling. Indeed, we are firmly convinced that the prehensility plays a crucial role not only in performing the stylistically correct paddling, but especially in realizing a more effective and powerful paddle stroke. This review highlights a great link existing between biomechanical and anatomical notions and sporting performance.
Acknowledgement to Reviewers of Journal of Intelligence in 2016
Authors:   J. Intell. Editorial Office
Published: January 2017

The editors of Journal of Intelligence would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2016.[...]
The Role of Lipid Membranes in Life’s Origin
Authors: Deamer David
Published: January 2017

At some point in early evolution, life became cellular. Assuming that this step was required for the origin of life, there would necessarily be a pre-existing source of amphihilic compounds capable of assembling into membranous compartments. It is possible to make informed guesses about the properties of such compounds and the conditions most conducive to their self-assembly into boundary structures. The membranes were likely to incorporate mixtures of hydrocarbon derivatives between 10 and 20 carbons in length with carboxylate or hydroxyl head groups. Such compounds can be synthesized by chemical reactions and small amounts were almost certainly present in the prebiotic environment. Membrane assembly occurs most readily in low ionic strength solutions with minimal content of salt and divalent cations, which suggests that cellular life began in fresh water pools associated with volcanic islands rather than submarine hydrothermal vents.
Ethyl (1R*,10S*,12R*,15S*)-4-Hydroxy-2-oxo-15- (2-oxo-1-pyrrolidinyl)-9-oxatetracyclo[10.2.2.01,10.03,8]hexadeca-3,5,7,13-tetraene-13-carboxylate
Authors: Heredia-Moya Jorge , Araya-Maturana Ramiro
Published: January 2017

N-Vinylpirrolidinone reacts with (E)-ethyl 5-hydroxy-3-(4-oxo-4H-chromen-3-yl) acrylate (1) through a domino reaction similar to that reported reaction for ethyl vinyl ether. Inverse electron demand Diels–Alder (IEDDA)–elimination-IEDDA generates isomeric tetracycles 5 and 6. The assignment of the relative stereochemistry of the products was made by comparing the proton couplings with those obtained by reaction with ethyl vinyl ether.
A Sparse Representation Algorithm for Effective Photograph Retrieval
Authors: Zhang Hong-Bo , Lei Qing , Zhong Bi-Neng , Du Ji-Xiang , Chen Duan-Sheng
Published: January 2017

Searching through information based on a photograph, which may contain graphics and images, has become a popular trend, such as in electronic books, journals, and products. Although many context-based methods have been proposed to retrieve images, most work focuses on selecting appropriate features for different objects. In the present study, we apply sparse representation to simultaneously retrieve image and graphics from a photograph. The sparse vector can be regarded as the similarity between the query photograph and dataset. The image with the largest entry (or several largest entries) can be assigned as the retrieved result. In the sparse representation framework, the common image features are used. Experimental results demonstrate that if the similarity vector in photograph retrieval is sparse, feature extraction is no longer critical. Compared with similar works in photograph retrieval, the proposed method has better retrieval accuracy.
Asymmetric Total Synthesis of Ieodomycin B
Authors: Lin Shuangjie , Zhang Jianting , Zhang Zhibin , Xu Tianxiang , Huang Shuangping , Wang Xiaoji
Published: January 2017

Ieodomycin B, which shows in vitro antimicrobial activity, was isolated from a marine Bacillus species. A novel asymmetric total synthetic approach to ieodomycin B using commercially available geraniol was achieved. The approach involves the generation of 1,3-trans-dihydroxyl at C-3 and C-5 positions via a Crimmins-modified Evans aldol reaction and a chelation-controlled Mukaiyama aldol reaction of a p-methoxybenzyl-protected aldehyde, as well as the generation of a lactone ring in a deprotection–lactonization one-pot reaction.
New Enzyme-Inhibitory Triterpenoid from Marine Macro Brown Alga Padina boergesenii Allender & Kraft
Authors: Ali Liaqat , Khan Abdul , Al-Broumi Muhammad , Al-Harrasi Rashid , Al-Kharusi Lubna , Hussain Javid , Al-Harrasi Ahmed
Published: January 2017

In continuation to our study of the chemical and biological potential of the secondary metabolites isolated from Omani seaweeds, we investigated a marine brown alga, Padina boergesenii. The phytochemical investigation resulted in the isolation of a new secondary metabolite, padinolic acid (1), along with some other semi-pure fractions and sub-fractions. The planar structure was confirmed through MS and NMR (1D and 2D) spectral data. The NOESY experiments coupled with the biogenetic consideration were helpful in assigning the stereochemistry in the molecule. Compound 1 was subjected to enzyme inhibition studies using urease, lipid peroxidase, and alpha-glucosidase enzymes. Compound 1 showed low to moderate α-glucosidase and urease enzyme inhibition, respectively, and moderate anti-lipid peroxidation activities. The current study indicates the potential of this seaweed and provides the basis for further investigation.
Biological Fuel Cells and Membranes
Authors: Ghassemi Zahra , Slaughter Gymama
Published: January 2017

Biofuel cells have been widely used to generate bioelectricity. Early biofuel cells employ a semi-permeable membrane to separate the anodic and cathodic compartments. The impact of different membrane materials and compositions has also been explored. Some membrane materials are employed strictly as membrane separators, while some have gained significant attention in the immobilization of enzymes or microorganisms within or behind the membrane at the electrode surface. The membrane material affects the transfer rate of the chemical species (e.g., fuel, oxygen molecules, and products) involved in the chemical reaction, which in turn has an impact on the performance of the biofuel cell. For enzymatic biofuel cells, Nafion, modified Nafion, and chitosan membranes have been used widely and continue to hold great promise in the long-term stability of enzymes and microorganisms encapsulated within them. This article provides a review of the most widely used membrane materials in the development of enzymatic and microbial biofuel cells.
Colloidal Fouling of Nanofiltration Membranes: Development of a Standard Operating Procedure
Authors: Al Mamun Md , Bhattacharjee Subir , Pernitsky David , Sadrzadeh Mohtada
Published: January 2017

Fouling of nanofiltration (NF) membranes is the most significant obstacle to the development of a sustainable and energy-efficient NF process. Colloidal fouling and performance decline in NF processes is complex due to the combination of cake formation and salt concentration polarization effects, which are influenced by the properties of the colloids and the membrane, the operating conditions of the test, and the solution chemistry. Although numerous studies have been conducted to investigate the influence of these parameters on the performance of the NF process, the importance of membrane preconditioning (e.g., compaction and equilibrating with salt water), as well as the determination of key parameters (e.g., critical flux and trans-membrane osmotic pressure) before the fouling experiment have not been reported in detail. The aim of this paper is to present a standard experimental and data analysis protocol for NF colloidal fouling experiments. The developed methodology covers preparation and characterization of water samples and colloidal particles, pre-test membrane compaction and critical flux determination, measurement of experimental data during the fouling test, and the analysis of that data to determine the relative importance of various fouling mechanisms. The standard protocol is illustrated with data from a series of flat sheet, bench-scale experiments.
Heating Changes Bio-Schwertmannite Microstructure and Arsenic(III) Removal Efficiency
Authors: Qiao Xingxing , Liu Lanlan , Shi Jing , Zhou Lixiang , Guo Yanhan , Ge Yuanying , Fan Wenhua , Liu Fenwu
Published: January 2017

Schwertmannite (Sch) is an efficient adsorbent for arsenic(III) removal from arsenic(III)-contaminated groundwater. In this study, bio-schertmannite was synthesized in the presence of dissolved ferrous ions and Acidithiobacillus ferrooxidans LX5 in a culture media. Bio-synthesized Sch characteristics, such as total organic carbon (TOC), morphology, chemical functional groups, mineral phase, specific surface area, and pore volume were systematically studied after it was dried at 105 °C and then heated at 250–550 °C. Differences in arsenic(III) removal efficiency between 105 °C dried-sch and 250–550 °C heated-sch also were investigated. The results showed that total organic carbon content in Sch and Sch weight gradually decreased when temperature increased from 105 °C to 350 °C. Sch partly transformed to another nanocrystalline or amorphous phase above 350 °C. The specific surface area of 250 °C heated-sch was 110.06 m2/g compared to 5.14 m2/g for the 105 °C dried-sch. Total pore volume of 105 °C dried-sch was 0.025 cm3/g with 32.0% mesopore and 68.0% macropore. However, total pore volume of 250 °C heated-mineral was 0.106 cm3/g with 23.6% micropore, 33.0% mesopore, and 43.4% macropore. The arsenic(III) removal efficiency from an initial 1 mg/L arsenic(III) solution (pH 7.5) was 25.1% when 0.25 g/L of 105 °C dried-sch was used as adsorbent. However, this efficiency increased to 93.0% when using 250 °C heated-sch as adsorbent. Finally, the highest efficiency for arsenic(III) removal was obtained with sch-250 °C due to high amounts of sorption sites in agreement with the high specific surface area (SSA) obtained for this sample.