bluuebunny/crossref_metadata_2025 huggingface dataset:
Nosocomial Mucormycetes Isolates of Local Environment and a Ligand based Antibiogram Predictive Model
Authors: Mishra Dhananjaya , Pattnaik Smaranika
Published: September 2024

Three nosocomial fungal strains were isolated from the local environment and encoded as NBF2, NBF3 and NBF7. The luxuriantly grown fungi in PDA, SDA and RBA were observed with slender entangled mycelia and black sporogonium. The SEM analysis made with the said fungi showed that three strains have similar morphology of sporangiospores with striped surface and grooves along with a long thin thread mycelia network. The spores were globular in shape with the surface devoid of grooves with filamentous hyphae. The three isolates were allowed to grow on six different Agar media as mentioned above and were considered for the nutritional typification of said isolates. 18s rRNA sequencing of the fungal isolates was carried out and was identified as strains of Rhizopus arrhizus provided with respective GenBank accession numbers OQ123495.1, OR018277.1 and OR651763.1. The antibiogram tests were carried out considering conventional antifungals and it was observed that the strains were sensitive towards the test drugs (Itraconazole and Terbinafine). Further a ligand based predictive antibiogram model was suggested, considering genes of interest. There was establishment of concurrence result between in vitro and in silico, deciphering that the isolates were originally nonpathogenic in nature. However further integrative research is obligatory in this area to decipher the underlying mechanisms of pathogenecity involved during Mucormycosis.
Screening of UV mutants of Listeria monocytogenes NCIM 5260 and growth optimization for production of listeriolysin O
Authors: Ramesh Mundlamuri , Jalaja Naravula
Published: September 2024

Listeria monocytogenes is a foodborne pathogen and the causative agent of the life-threatening disease listeriosis. To address the severity and health risk caused by Listeria, a potential and safe vaccine for protecting humans is the need of the day. In the present work, mutants of L. monocytogenes were isolated by exposing the L. monocytogenes NCIM 5260 to UV rays for different time periods. Of the isolated ultraviolet (UV) mutants, the mutant producing maximum toxin listeriolysin O (LLO) was selected for improving the production of LLO (g/L) further by optimizing the medium composition using statistical methodology. Carbon and nitrogen sources were selected using two independent Plackett Burmann designs. For optimizing the final medium composition, sucrose, peptone, pH of the medium, temperature and rpm were selected at five different levels using central composite rotatable design by Response surface methodology. Optimized medium composition of sucrose (1 g/L), peptone (10 g/L), pH (7.6), temperature (38°C), speed of the shaker (200 RPM) yielded 0.64 g/L of LLO toxin. A 3.5-fold increase in the LLO toxin (g/L) titer was observed after medium optimization. LLO toxin thus produced can be inactivated and used as a vaccine candidate either as LLO toxoid and in combination with other toxoids as bivalent vaccine.
The Batal′noe settlement, the Batal′noe graveyard, and the NW Graveyard of Batal′noe 1 (Republic of Crimea, Leninsky Region)
Authors: Ермолин С.А. , Бонин А.В.
Published: September 2024

В июне – октябре 2017 г. близ с. Батальное (Ленинский р-н Республики Крым) отделом сохранения археологического наследия Института археологии РАН проведены спасательные археологические исследования территории объекта культурного наследия поселение Батальное 1, а также могильника Батальное и северо-западного могильника Батальное 1. В ходе работ на поселении Батальное 1 было раскопано 19625 кв.м. Открыто 458 хозяйственных ям, пять жилищ, очаг и водосборник. Поселение датируется втор. пол. XVIII в. Кроме того, на площади 3275 кв. м исследована южная часть могильника Батальное 1. В ходе работ выявлено 152 погребения. Могильник датируется XIX в. На северо-западном могильнике Батальное 1 на площади 1650 кв. м раскопано 36 погребений.

Over June to October 2017, a team from the Preservation of Archaeological Heritage department of the Institute of Archaeology of the Russian Academy of Sciences, undertook studies close to Batal′noe village, at the area of the Batal′noe I settlement, and also at the graveyard of Batal′noe and the NW Graveyard of Batal′noe 1. During the study at Batal′noe I, 19,625 square metres of ground was excavated. These works revealed 458 household pits, five dwellings, fireplaces, and a water storage pool. The settlement dates back to the second half of the 18th century. Further excavations, totally 3275 square metres, were made at the graveyard of Batal′noe-1, which was dated to the 19th century. The North-Western graveyard of Batal′noe was similarly excavated over an area of 1650 square metres, revealing 36 burials.
The Kremlin town of Pereslavl′-Zalessky (Yaroslavl′ Region)
Authors: Зейфер В.А.
Published: September 2024

В 2017 г. экспедиция Института археологии РАН провела обследование участков на территории кремля г. Переславля-Залесского. Общая площадь исследований составила 114,6 кв. м при мощности культурного слоя от 0,70 до 2,20 м. В результате работ получены новые данные о топографии и сохранности культурного слоя Переславского кремля. В границах кремля выявлен участок пашни XIII–XIV вв. Коллекция индивидуальных находок представлена 144 изделиями из стекла, камня, черного и цветного металла, кости и глины.

In 2017 an expedition from the Institute of Archaeology of the Russian Academy of Sciences undertook investigations of an area within the kremlin of the town of Pereslavl′-Zalessky. The overall area studied wsa 114.6 square metres, with a cultural layer depth of between 0.70 m to 2.20 m. The results of the study were that new data for the topography and preservation of the cultural layer of Pereslavl′-Zalessky were obtained. A plot of arable land (ploughed land) from the 13th–14th centuries was revealed within the area of the kremlin. A collection of individual finds was made, including 144 jewellery items made from glass, stone, black and non-ferrous metals, bone, and clay.
The earthwork mound of Uzlovoe Severnoe (Republic of Crimea, Leninsky district)
Authors: Кубарев Г.В. , Рукавишникова И.В.
Published: September 2024

В статье рассматриваются результаты аварийных раскопок кургана Узловое Северное, проведенных осенью 2017 г. Крымским отрядом ИАЭТ СО РАН на территории Республики Крым. Исследованный курган расположен в юго-восточной части Крымского п-ва, в окрестностях г. Феодосии и входил в зону строительства автомобильной трассы «Таврида». В кургане исследовано 38 объектов, большинство из которых являлись погребениями. Наиболее многочисленная группа погребений относилась к эпохе ранней бронзы (III – середина II тыс. до н. э.). В скифо-сарматское время и в эпоху Средневековья курган также использовался для совершения в нем впускных погребений. Новые археологические материалы, полученные в ходе исследования кургана, должны представлять интерес для специалистов по археологии и истории Крымского полуострова.

This article covers the results of rescue archaeological work undertaken at the Uzlovoe Severnoe earth mound (barrow), made during autumn of 2017 by the Crimean Team of the Institute of Archaeology of the Russian Academy of Sciences within the territory of the Crimean Peninsula. The barrow which was investigated is located in the south-eastern area of the peninsula, within the construction zone of the new Tavrida highway. 38 items were surveyed within the barrow, of which the majority were burials. The most numerous group of these burials related to the Early Bronze Age (mid-3rd to 2nd century BC). During the Scythian and Sarmatian period, and the Middle Ages, the barrow continued to be used for in-situ burials. New archaeological material, obtained during the course of this investigation, will be of interest to specialists in the history of the Crimean peninsula.
Earthworks No 2 from the Ak-Monayskaya 1 earthworks group
Authors: Рукавишникова И.В. , Бейлин Д.В.
Published: September 2024

Статья посвящена результатам исследования участка некрополя I–II вв. н. э. укрепленного посе- ления Городище 11 км, обнаруженного при археологических исследованиях ОАН «Курганная группа Алек- сандровские скалы 1». Общая площадь исследованных участков составила 6364 кв. м, где было исследовано 244 погребения. Помимо погребений I–II вв. н. э. под насыпью кургана 1 были обнаружены погребения, совер- шенные в катакомбах II тыс. до н. э. На вершине скального массива кургана 2 под основательно разрушенной каменной конструкцией выявлено центральное погребение кургана IV–III вв. до н. э.

This article is devoted to the results of a study carried out at a section of the necropolis of the Ist- 2nd century AD at the fortified settlement of Gorodisha, found during OAS archaeological investigations at the ‘Earthwork Group of Alexandrovskie Cliffs I’ site. The overall area of site surveyed was 6364 square metres, and 244 burials were located. In addition to burials from the 1st and 2nd centuries AD, a further burial was found in catacombs dates to the 2nd millenium BC, under rockfill from the earthwork. At the top of the rock structure of Earthwork II. below the ruins of a stone structure, the central burial mound of the 4th–3rd centuries BC was located.
The necropolis of Volna-1 (2017) (Krasnodar Territory, Taman Peninsula)
Authors: Мимоход Р.А. , Сударев Н.И. , Успенский П.С.
Published: September 2024

В статье представлены итоги работ Сочинской экспедиции ИА РАН в 2017 г. на античном некрополе Волна 1, расположенном на Таманском полуострове. В течение сезона 2017 г. на территории некрополя было исследовано 265 погребений и 132 комплекса. В статье анализируются планиграфия, погребальный обряд и хронология исследованных комплексов, а также дана характеристика основных категорий погребального инвентаря. На некрополе выявлен участок с погребениями, не характерными для греческих некрополей, а также погребений, совершенных по-варварскому, не характерному для греков обряду, что позволяет говорить о наличии в этом поселении групп варварского населения.

This study presents the results of work undertaken by the Sochi Expedition group of the Institute of Archaeology of the Russian Academy of Sciences during 2017 at the ancient necropolis of Volna-1, located on the Taman Peninsula. During the summer of 2017, a total of 265 burials and 132 necropolis complexes were investigated at this funerary site. The article analyses the layout, funerary rites, and chronology of the complexes under consideration, besides giving an overall characterisation of the funerary regalia found. At the necropolis an area was identified with burials which are not typical for Greek funerary complexes, as well as graves laid out in a barbarian style, and also untypical of Greek rites. This enables us to say that an area of the necropolis was specially assigned to burials from a local barbarian population.
Underwater investigations at Ak-Burun Bay
Authors: Ольховский С.В.
Published: September 2024

В 2017 г. на ОАН «Бухта Ак-Бурун» завершились подводные раскопки участков дна под запроектированными опорами Крымского моста в акватории Керченской бухты. Общая площадь раскопок составила 3000 кв. м, при этом найдено почти 50 тыс. археологических находок – в основном фрагменты керамических сосудов V в. до н. э. – XIII в.н. э. В результате доследования площадь ОАН уточнена и ныне оценивается в 75 тыс. кв.м.

Underwater studies were made during 2017 of OAS areas of Ak-Burun Bay, of areas of the water bed located within the projected area of supports for the Kerch′ Crimea Bridge, and the area around Kerchenskaya Bay. The overall area studied totalled 3000 square metres. A total of over 50,000 archaeological finds was made. These are primarily fragments of ceramic vessels of the 5th to 8th centuries AD. As a result of the studies, the total area of the OAS was calculated, and is now estimated to cover 75,000 square metres.
Earthwork mound group at Nizhniy Solnechnyy 1 (Republic of Crimea, Leninsky Region)
Authors: Рукавишникова И.В. , Бейлин Д.В. , Белик Ю.Л. , Гаспарович С.Г.
Published: September 2024

В статье приводится информация об исследованной курганной группе Нижний Солнечный I, где найдены остатки построек, культурных напластований регулярно организованного летнего военного лагеря крепости Керчь, существовавшего с 60‑х гг. XIX в. до начала XX в. Исследована его часть с регулярной системой возведения палаток. Об уникальности объекта археологического наследия позволяет судить многочисленный материал находок, относящийся к военной деятельности и личным вещам русских войск.

This article provides information on the studies into the earthwork group at Nizhniy Solnechnyy 1, where remains of structures and cultural strata relating to regularly held summer military camps of Kerch Fortress – which were held prior to the 1860s, until the early 20th century – have been found. An area for regularly erecting tents was identified and studied. The uniqueness of this archaeological data is witnessed by a large number of finds relating to military activities and personal belongings of Russian soldiers.
Военная археология. Сборник материалов научного семинара. Выпуск 4.
Authors: Двуреченский О.В.
Published: September 2024

Настоящий очередной военно-исторический сборник представляет на своих страницах комплекс результатов научных исследований, связанных с историей военного дела Восточной Европы, Кавказа, Сибири в эпоху раннего и развитого Средневековья. В статьях рассматриваются как археологические находки, связанные с защитным и наступательным средневековым вооружением, так и вопросы военной истории, тактики, формирования боевых подразделений.
Новая атрибуция шлема из реки Мульта
Authors: Kubik A.L. , Nicolle D.
Published: September 2024

The article discusses a helmet found in the middle or late 1980s on the bank of the river Multa, a tributary of the River Kotun in the southern Altai Mountains. This helmet was often associated with the presence of Mongols in the region during the 13th-14th centuries AD. However the author consider this to be highly unlikely. On the basis of a detailed comparative analysis, the author puts forward a thesis which dates the object to either the early-Islamic period, i.e. to the first half of 8th c. AD. Specifically, it is suggested that the appearance of the helmet in the southern Altai Mountains may be attributed to the era of rapid Islamic conquest in Asia. Additionally, the article argues that in the late Sasanid period or early post-Sasanid period a new sub-type of helmets came into existence in Sogdiana. This was the tall, conical body form spangenhelme type with a lower band which is itself divided into front and back parts and is sometimes decorated with a triangular iron plate at the front. Furthermore, it is proposed that the Multa river helmet has certain similarities with helmets shown in Sogdian murals of the 7th to 9th centuries AD.

В статье рассматривается шлем, найденный в середине или конце 1980-х годов на берегу реки Мульта (приток реки Катунь) на Южном Алтае. Часто этот шлем связывают с присутствием в регионе монголов в XIII–XIV вв. Тем не менее авторы считают это крайне маловероятным. На основе детального сравнительного анализа авторы выдвигают тезис, что шлем относится к раннему исламскому периоду, то есть к первой половине VIII в. Предполагается, что появление шлема в южной части Алтайских гор можно отнести ко времени стремительных исламских завоеваний в Азии. Кроме того, в статье высказана точка зрения, что в конце Сасанидского периода или раннем Постсасанидском периоде в Согдиане появляется новый подтип шлемов. Это был шлем типа шпангельхельм с высокой тульей конической формы с венцом, разделенным на переднюю и заднюю части. Иногда передняя часть венца оформляется в виде треугольной железной пластины. Кроме того, предполагается, что шлем из реки Мульта имеет определенное сходство со шлемами, изображенными на согдийских росписях VII–IX вв.
ПЕРЕКРЕСТЬЕ МЕЧА ИЗ РАСКОПОК ВИЗАНТИЙСКОГО ХЕРСОНА
Authors: Баранов Г.В.
Published: September 2024

В статье рассматривается перекрестье меча, найденное на Херсонесском городище при раскопках, производившихся в 1905 г. под руководством К.К. Косцюшко-Валюжинича. Перекрестье представляет собой редкий образец вооружения и, на данный момент, является единственным перекрестьем такого типа, происходящим с территории Византийской империи. Несмотря на это, перекрестье более 100 лет не вызывало интереса исследователей. В 2009 г. перекрестье исследовал болгарский археолог В. Йотов. Статья болгарского исследователя была посвящена поиску аналогий предмету и не содержала подробной публикации памятника. Настоящая статья заполняет этот пробел. На основании археологического контекста и аналогий датировку херсонесского перекрестья предлагается ограничить концом X – началом XI вв., а общую датировку перекрестий такого типа – концом X – первой половиной XI вв.

The article describes a cross-guard from archaeological excavations of Chersonesus which were conducted in 1905 under the guidance of Karl Kazimirovich Kosciuszko-Valyuzhinich. The crossguard is a rare example of such type of armament and for now it is the only cross-guard of its type which originates from the territory of the Byzantine Empire. Despite these facts the cross-guard didn’t attract the interest of researchers for more than 100 years. In 2009 it was studied by the Bulgarian archaeologist V. Yotov. His article was devoted to the search of analogies and didn’t contain a detailed description of the object. The current article fills this gap. On the basis of the context and the analogical objects the article suggests to limit the dating by the end of the 10th and the beginning of the 11th century for the Chersonesus cross-guard and by the end of the 10th and the first half of the 11th century for the cross-guards of this type in general.
Details of Blade Weapons from the Excavations of the Medieval Drutsk.
Authors: Плавинский Н.А.
Published: September 2024

Древнерусский город Друцк (сейчас Толочинский район Витебской области Республики Беларусь) впервые упоминается под 1078 г. В древнерусское время Друцк был одним из наиболее зна- чительных городских центров Полоцкой земли. В ходе раскопок Друцка была собрана достаточно представительная коллекция вооружения. В данном сообщении рассматриваются немногочислен- ные, но крайне интересные находки деталей клинкового оружия, а именно: две детали рукоятей мечей, перекрестье сабли, целый и фрагментированный наконечники ножен мечей.

The Old Rusian town Drutsk (present-day Talachyn district of Vitebsk region in the Republic of Belarus) was first mentioned in 1078. In Old Rusian times Drutsk was one of the most important urban centers of the Polotsk land. During the excavation of Drutsk fairly representative collection of weapons was collected. This publication discusses a few, but extremely interesting finds of blade weapons details, namely: two details of swords handles, saber cross-guard, fully preserved and fragmented sword chapes.
Archaeology of Vladimir-Suzdal land. The next issue of the edition is based on the materials on the materials of the 8th scientific-practical seminar «Archaeology of VladimirSuzdal land», which was held on the 31st October – 1 November, 2017 in the city of Vladimir.
Authors: Макаров Н.А.
Published: September 2024

Очередной выпуск сборника составлен на основе материалов 8-го научнопрактического семинара «Археология Владимиро-Суздальской земли», прошедшего 31 октября – 1 ноября 2017 г. в г. Владимире. В публикациях представлены результаты новейших археологических работ в историческом центре Северо-Восточной Руси, а также материалы исследований ряда средневековых памятников Верхнего Поволжья и новгородских земель. Освещаются исследования территорий исторических городов, архитектурных памятников, средневековых сельских поселений и погребальных древностей, ряд общих вопросов изучения материальной и духовной культуры населения исторического ядра Владимиро-Суздальской земли. 

Archaeology of Vladimir-Suzdal land. The next issue of the edition is based on the materials on the materials of the 8th scientific-practical seminar «Archaeology of VladimirSuzdal land», which was held on the 31st October – 1 November, 2017 in the city of Vladimir. The results of the latest archaeological works in the historical center of North-Eastern Russia, as well as the research materials of a number of medieval sites of of Upper Volga area and Novgorod lands are presented in the publications. The research of territories of historical cities, architectural monuments, medieval rural settlements and funerary antiquities, a number of the general questions studying of material and spiritual culture of the population of a historical core of Vladimir-Suzdal land covered in the materials of the seminar.
wHITE STONE VLADIMIR LAPIDARY IN N. N. VORONIN’S DIARIES
Authors: Тимофеева Т.П.
Published: September 2024

Дневники Н. Н. Воронина 1937, 1938, 1939 и 1955 гг. об археологических раскопках и разведках во Владимире и Боголюбове содержат богатый материал о белокаменных, в том числе наиболее известных, резных находках, входящих ныне в лапидарий (коллекцию белого камня) Владимиро-Суздальского музея-заповедника. Дневники содержат описания места и обстоятельств обнаружения предметов, рисунки, обмеры, предоставляя возможность подробной атрибуции музейных экспонатов. 

The archaeological finds of N. N. Voronin in Bogolyubov and Vladimir make a significant part of the white stone lapidary of the Vladimir-Suzdal Museum-reserve. The paper deals with the materials of N. N. Voronin’s diary entries, which contains descriptions of various white stone details. Diaries accurately localize more than two dozen finds – carved stones and fragments, which were repeatedly published in the works of N. N. Voronin and G. K. Wagner. Diaries introduce these stones in the context of the archaeological research of monuments.
GREAT SETTLEMENT wITH NO TRACES OF FORTIFICATIONS IN SURA REALM OF SUzDAL PRINCE REACHES BORIS KONSTANTINOVICH
Authors: Грибов Н.Н.
Published: September 2024

В статье изложены краткие итоги первых исследований большого неукрепленного поселения Курмыш-4, обнаруженного на левом берегу реки Суры в 2007 г. Рассмотрены основные группы инвентаря. Дана характеристика особенностям комплекса керамической посуды. Предложен подход к историко-социологической интерпретации данного поселения. По летописным данным, поселение находилось во владениях суздальского князя Бориса Константиновича. Вместе с городищем Курмыш оно входило в единую поселенческую агломерацию, обладающую городскими чертами. 

The article describes the brief the results of the first large studies of settlement with no traces of fortifications Kurmysh-4, found on the left bank of the Sura River in 2007 year. The main group of equipment. Characterised by the ceramic ware. An approach to historicalsociological interpretation of this settlement. According to the chronicles the settlement was in the realm of suzdal Prince Boris Konstantinovich. However, settlement Kurmysh it was a unified settlement agglomeration with urban characteristics.
Analyses of the perturbative motion in the Coupled Nosé-Hoover equation for assessing the system parameter values
Authors: Fukuda Ikuo , Moritsugu Kei
Published: September 2024

The coupled Nosé-Hoover (cNH) equation offers a physical state sampling technique employed in molecular dynamics simulations, requiring fewer iterations and using a single-replica approach. The key to enhancing sampling efficiency is the ability to dynamically fluctuate the temperature of the Nosé-Hoover thermostat according to a predefined distribution. While the global behavior of cNH dynamics has been characterized probabilistically due to the existence of an invariant measure, this study focuses on a detailed analysis of the local behavior of these dynamics. We captured the local behavior of the temperature system (TS), a distinctive feature of cNH, using the TS mass and the Hessian of the TS potential. We conducted a comprehensive analysis of the Hessian and utilized these insights to assign suitable system parameter values for the cNH method. Given that the choice of parameter values influences the convergence of the distribution, selecting them appropriately is crucial from a practical perspective. In this study, we developed a method for determining suitable parameter values and validated it numerically by applying it to model systems. Our findings provide a foundation for achieving efficient and straightforward sampling simulations.
NHC-Catalyzed Transition-Metal-Free Allylation of Aldehydes with MBH Carbonates and Their Michael Addition-Elimination-Cope Rearrangement Cascade: Facile Access to Sacubitril API
Authors: Kale Tushar , Jagtap Sayali , Mhaske Santosh
Published: September 2024

We report herein, a novel NHC-catalyzed transition-metal-free chemoselective allylation of aldehydes with Morita-Baylis-Hillman (MBH) carbonates using inorganic base. Fascinatingly, use of an organic base follows a different mechanism leading to highly functionalized 1,5-dienes via Michael addition-elimination reaction followed by [3,3]-sigmatropic cope rearrangement. The described method harnesses a new Csp2–Csp3 bond to access α-methylene-γ-oxo-γ-substituted ester derivatives paving a way to facile synthesis of potent natural products and APIs. A broad range of aromatic and aliphatic aldehydes with MBH carbonates were employed to provide a variety of interesting butanoate and dienyl ketone scaffolds in good to excellent yields. This chemistry has been extended to the efficient syntheses of sacubitril API and γ-butyrolactone scaffold found in many natural products and APIs.
In vitro antischistosomal activity of 2-aroyl-benzofuran derivatives against Schistosoma mansoni
Authors: Vieira Tatiana , Dias Herbert , Santos Daiane , Magalhães Lizandra , Crotti Antônio
Published: September 2024

Five 2-aroylbenzofuranes were synthesized by condensation between α-bromoacetone and an ortho-hydroxybenzaldehyde or ortho-hydroxy-acetophenone and evaluated for their in vitro antischistomal effects against adult Schistosoma mansoni worms. Below 200 µg/mL, none of the tested 2-aroylbenzofurans killed adult S. mansoni worms. On the other hand, at 200 µg/mL all the tested compounds reduced the motor activity of adult S. mansoni worms after treatment for 72 h. At 200 µg/mL, compound 1 was the only one to decrease the motor activity of 67% of the worms after incubation for 24 h. The methyl group at C6 and the nature of the substituent at ring A play important roles in the efficacy of 2-aroylbenzofurans in reducing the worm motor activity.
Peroxy-Carbenium Mediated Asymmetric Synthesis of 1,2-Dioxanes and 1,2-Dioxolanes
Authors: Ferrié Laurent , Figadère Bruno , Jamey Nicolas , Champciaux Bastien
Published: September 2024

The endoperoxide scaffold is found in numerous natural products and synthetic substances with pharmaceutical interest. The principal challenge to their synthetic access remains the preparation of chiral compounds, due to the weakness of the peroxide bond, which limits the scope of available or applicable methods. Here, we demonstrate how peroxycarbenium species can be trapped by silylated nucleophiles with high enantioselectivities, and diastereoselectivities when applicable, using a chiral imidophosphorimidate (IDPi) as catalyst. The scope of the methodology is broad, encompassing a large varie-ty of enoxysilanes, and yielding 1,2-dioxanes or 1,2-dioxolanes. Peroxides can be converted into chiral alcohols or trans-epoxides, and the methodology was applied in a key step of the total synthesis of ethyl plakortide Z, which demonstrated enhanced selectivity. Kinetic studies demonstrated that tert-butyldimethylsilylated nucleophiles are more potent than trime-thylsilylated ones. Furthermore, it was observed that the reaction necessitates an induction period, indicating the formation of a silylium species that behaves as the true catalyst.
La necesidad de una democracia efectiva y un Estado eficiente
Authors: Pérez Luyo Ricardo
Published: September 2024

En el proceso de construcción social de la democracia, los seres humanos hemos tratado de encontrar una serie de reglas de juego (instituciones) que coadyuven a preservar nuestra existencia como colectividad. Esta construcción social constituye un aprendizaje permanente en el sentido que podemos determinar el conjunto de normas que habrían generado los incentivos adecuados para lograr una arquitectura de autogobierno con resultados positivos para la cohesión social y el bienestar, y viceversa. En el presente ensayo, enfatizamos sobre la importancia para nuestras sociedades —y en particular para el caso peruano— del establecimiento de una apropiada legislación electoral que impulse e incentive la conformación de gobiernos efectivos (resultados) y que a su vez la democracia sea una adecuada plataforma política que —en paralelo a un Estado “músculo”— puedan ser los motores institucionales adecuados para lograr el bienestar anhelado. Requerimos de una importante capacidad para entender e interpretar los procesos sociales, políticos y económicos que vivimos en el presente siglo xxi, y que son complejos: crecimiento económico, partidos políticos institucionalizados, cultura democrática, una burocracia de alto nivel, entre otros.
Tempestad en Egipto: prensa y diplomacia peruana frente a la crisis de Suez (1956)
Authors: Gálvez Carcelén Mauricio
Published: September 2024

En julio de 1956, el presidente egipcio Gamal Abdel Nasser nacionalizó el canal de Suez, gran arteria comercial para el mundo occidental y administrada por Gran Bretaña y Francia. La reacción anglo-francesa fue furibunda; empero, la posición de los demás actores globales no iría en la misma dirección. El Perú, país periférico y con presencia diplomática en la Organización de las Naciones Unidas (ONU), expresaría su postura frente a la crisis de Suez en este contexto de Guerra Fría y bipolaridad. Este artículo explorará, en primer lugar, el registro de los hechos por el decano de la prensa peruana: El Comercio. En segundo lugar, analizará la postura diplomática peruana de su delegación ante la ONU, presidida en aquel entonces por Víctor Andrés Belaúnde.
Determination of harvesting time and quality of kesum (Persicaria minor) in
different cultivation systems
Authors: M.N. Mohd Effendi , M. Nurhazwani , M. Razali , M. Yaseer Suhaimi , T. Muhammad Faidhi , A.H. Ahmad Arif Luqman , Z.A. Siti Nurzahidah , M.Y. Saidatul Aqilah
Published: September 2024

Various planting techniques and systems have been studied and practised to produce high
quality and yield crops. Among the cultivation systems that are widely used in agriculture
are open-field planting, fertigation, and hydroponic systems. Harvesting at the optimal
maturity stage is a vital approach to obtaining crops with high quality and nutrient content.
Kesum (Persicaria minor) is an aromatic herb that is very native to Southeast Asian
countries and is synonymous with Asian cuisine because of its ability to enhance flavour
in dishes and is also used as a traditional medicine. This study was conducted to evaluate
the optimal harvesting time and quality of kesum in different cultivation systems, which
were open field planting, fertigation, and hydroponic systems (controlled and semicontrolled environment). In an open field and fertigation system, kesum were planted on
soil but with different fertilizer rates and applications. While for the hydroponic system,
kesum were planted in 156 cm × 63 cm polystyrene boxes filled with water in a controlled
and semi-controlled environment (closed and opened rain shelter structure, respectively).
Samples were harvested at different maturity stages 8, 12, 16, and 18 weeks after planting.
The postharvest quality of the samples was measured at every harvesting time. The plant
fresh weight was found to increase at every harvesting week in all cultivation systems,
whereas optimal weight was reached at week 16 after planting (296.18 g in controlled
hydroponic, 509.45 g in semi-controlled hydroponic, 639.20 g in fertigation and 751.5 g in
open field). Meanwhile, the total phenolic content (TPC) was found to increase to optimal
content at week 12 for kesum planted in semi-controlled hydroponic (183.47 mg/g),
fertigation (333.30 mg/g) and open field (435.32 mg/g) system but at week 16 in
controlled hydroponic (207.43 mg/g). Ascorbic acid and water content showed a
decreasing trend throughout the harvesting weeks, in contrast to the total soluble solids
content, total titratable acidity, and pH value, which increased in all four cultivation
systems. Based on the data obtained, the optimal harvesting time for kesum planted in
either fertigation, conventional or hydroponic systems is at week 16 after planting for
obtaining kesum with high yield and quality.
Desafios da educação infantil para a aprendizagem das crianças no cenário da pandemia
Authors: Dolci Mário Henrique , Gileno Rosangela Sanches da Silveira , Argenti Marcia Cristina
Published: September 2024

No cenário da pandemia, a estampa da desigualdade social refletida no acesso aos recursos tecnológicos pelas diferentes camadas sociais mostrou-se um desafio para a garantia de direitos aos alunos da pré-escola. O artigo tem por objetivo refletir acerca dos impactos da pandemia no processo educativo. A metodologia da pesquisa envolveu um estudo de caso em duas turmas da faixa etária de cinco anos de uma Instituição Municipal de Educação Infantil de uma cidade de médio porte no interior do Estado de São Paulo no ano de 2021. Os procedimentos metodológicos envolveram a análise dos registros escolares das atividades em tempos pandêmicos daquelas turmas e os relatos dos docentes das duas turmas daquela etapa. Os resultados apontam os obstáculos enfrentados e o prejuízo na aprendizagem das crianças em virtude do afastamento do espaço escolar.
The Fog has not Lifted: No Reduction in Complications for Partial REBOA in the AAST AORTA Registry
Authors: Gomez Micaela , Wood Elizabeth , Saxena Juhi , Neff Lucas P , Forssten Maximillian Peter , Johnson Austin , Williams Timothy K , Ribeiro Jr Marcelo , Joseph Bellal , DuBose Joseph , Mohseni Shahin
Published: September 2024

Background: Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) is a potentially lifesaving but polarizing therapy due to the associated morbidity and uncertainty of who might benefit. Techniques such as partial (p)REBOA that provide hemodynamic support while reducing distal ischemia are now captured in the Aortic Resuscitation in Trauma and Acute Care (AORTA) registry. We hypothesized that pREBOA would be associated with improved mortality and fewer adverse outcomes.Methods: The AORTA registry was queried for adult patients who received complete (c)REBOA or pREBOA between 2020 and 2022. Patients were excluded if they had a head Abbreviated Injury Scale (AIS) ≥three or an AIS of six in any body region. Outcome measures were complications and mortality. Poisson regression analyses identified the independent effect of the type of approach on outcomes.Results: 164 patients met the inclusion criteria, with pREBOA used in 36% of cases and no significant difference in patient demographics, injury characteristics, or injury severity between pREBOA and cREBOA. There was no difference in mortality rate (44.1% vs 45.7%). After adjusting for potential confounders, no statistically significant difference in complications was detected between the two approaches [adjusted IRR (95% CI): 1.11 (0.54–2.27), p = 0.777]. This association persisted after subgroup analysis of aortic Zone one vs Zone three deployment.Conclusions: In this registry analysis, pREBOA did not reduce morbidity or mortality compared to cREBOA. Improving the granularity of clinical metrics in the AORTA registry is essential to understanding whether patients will benefit from pREBOA, and how to best implement this controversial resuscitation adjunct.
Migration, Anthropology, and Voice
Authors: Graw Knut
Published: September 2024

One of the most striking features of contemporary migration to Europe and elsewhere is the almost complete anonymity of its pro-tagonists. The most immediate effect of this anonymity has been the emergence of the figure of the ‘migrant’ in public consciousness with little attention for national and personal backgrounds. A related effect of this anonymization of migration has been that, without personal identity, the individuals concerned also seem to have no history, leading to a rather de-historicized view of migration in the public debate. The present text attempts to counter these tendencies by focusing on an individual narrative of migration between West Africa and Europe, dating back to the late 1980s. On a more theoretical plane, by reflecting on an individual account the article reflects on the question of voice as one of the most central problems of ethnographic representation, both in migration studies and more generally.
Health Education of Parents About Baby Massage for Stunting Toddler in The Working Area of The Sumbergempol Puskesmas 2024
Authors: Oktaviana Friska , Widyawati Evita , Handayani
Published: September 2024

The decline in stunting rates in Indonesia is very slow. Stunting is a condition of failure to thrive in toddlers under 5 years of age which can have a long-term impact on the quality and productivity of the nation's next generation of children. In this era of development, many parents still believe in shamans and lack knowledge about the many benefits of baby massage which can help optimize children's growth and development to prevent stunting. This community service aims to provide health education to parents about baby massage to reduce stunting rates. The results and discussion of this community service were positive responses from 30 parents who had taken part in the activity of providing health education about the benefits of baby massage on children's growth and development. Providing intervention in the form of baby massage can stimulate growth hormones in children so that mothers or parents have the knowledge and motivation to carry out baby massages regularly. The conclusion from this community service is that there is a significant influence of health education about baby massage on mothers' attitudes towards being able to do baby massage as an effort to prevent stunting.
The Impact of Talent Management on Intention to Stay: The Mediating Role of Justice
Authors:   ,   Lebanese American University -- Chouran Beirut, ElHayek Rachelle Tannios
Published: September 2024

Organizations are now focusing on making people want to stay with their company more than ever. However, more research needs to be done on how talent management (TM) methods affect the desire to stay put. The purpose of this study was to look into how organizational justice (OJ) affects the link between TM and the desire to stay. A questionnaire was sent to different companies in Lebanon to get information. SPSS was used to do hierarchical multiple regression. The results showed that organizational justice (OJ) partially mediated the link between TM practices and intention to stay. This shows that the intention to stay is affected by many things, such as OJ. The results also showed that TM practices have a big effect on the desire to stay. This means that TM practices need to be changed to keep employees while also making the workplace more just and fair. Also, the study found that workers are not likely to stay in their current jobs if their needs are not met. So, HR workers should look at their own policies again to make the workplace a better place for employees to learn and grow. Even though workers feel like they are being heard, this doesn't have a big effect on the results. Employees should be more involved in making decisions, and managers should communicate clearly with all of them. The study also found that internal learning and growth is one of the most common TM practices. Even though in-house training is important, offering a wider range of learning and growth opportunities could make people even more likely to stay. The study also found that TM practices and OJ have a big effect on this link. On the other hand, everyone has a different idea of what is fair and just. Organizational psychologists can use this study to learn more about the psychological effects that make people feel fairer and just. Leaders should know that different methods may be needed for different people in different situations. The researchers know of few studies that have looked at the link between TM practices and the desire to stay, and none of these studies have fully looked into the role of OJ. In this way, the results add something useful to the current research and lay the groundwork for more studies to come.
The Gem of Tripoli, A Unique Mamluk Star Domical Pattern, where Visual Arts and Mathematical Sciences Intersect
Authors:   ,   Lebanese American University -- Chouran Beirut, Shehabeddine Rana
Published: September 2024

Hidden within the labyrinthine streets of Trāblus ash-Shām lies a forgotten monument from the Mamluk period, known as al-Mashhad, overlooked by travelers and erased from local memory. Despite its central location, this enigmatic structure remains shrouded in mystery, its function obscured by time and neglect. Adorning its front facade is a captivating testament of artistic ingenuity and craftsmanship: a colorful star domical pattern gracing its quarter hood, a beautiful example of the intricate interplay of Islamic geometric artistry and polyhedral geometry. A thorough formal analysis of the monument with particular focus on its portal, reveals the unique features that set al-Mashhad apart from other monuments in Tripoli and in the broader region. This research places this portal within a comparative study of the historical use of star patterns on mihrabs, portals, and domes in Medieval Cairo and Syria. It also explores insights into the evolution of the star geometric patterns in architectural designs and their relation to the development of mathematics at the time. Rooted in Arabic primary sources, this research aims to unveil the monument’s historical narrative, amplifying its significance in the annals of Mamluk architectural history. This thesis argues that al-Mashhad epitomizes a unique fusion of Seljuk mathematical innovation and Syrian aesthetic expression, showcasing a harmonious balance between precision and beauty. It also marks a pivotal point in the political history of Mamluk Tripoli with the resurgence of architectural patronage under the Circassian Mamluks. Furthermore, this research underscores Tripoli’s significant contribution to the manifestation, richness, and maturity of the Mamluk geometric domical decoration, offering a deeper understanding of the city’s cultural legacy.
Administración de la Salud Pública
Authors: Rodríguez Calderón Nancy Jacqueline , Patiño Zambrano Viviana Paola , Touriz Bonifaz María Antonieta , Álvarez Álvarez Agustín Hugo , Píngel Erráez Juan Carlos , Palacios Tavara María Del Socorro , Lindao Cañizares Miriam Gisela , Guerrero Pozo Erika Pilar , Santillan Cuero Elaynne Mariela , Villegas Villao Nancy Elizabeth , Vargas Vera Tanya María , Vera Espinoza Yuridia Lisbeth
Published: September 2024

La pandemia de COVID-19 ha marcado un antes y un después en la forma en que se ha entendido la salud y ha situado en el centro del debate político mundial el tema de la administración de la salud pública. La crisis sanitaria ha dejado al descubierto la fragilidad de los sistemas de salud ante la propagación de enfermedades a nivel mundial, resaltando la necesidad apremiante de reforzar su capacidad de respuesta en todos los niveles asistenciales para hacer frente a emergencias y aplicar medidas preventivas y de control que salvaguarden la salud y bienestar de la población. En el contexto antes descrito, el libro, Administración de la Salud Pública, se presenta como una herramienta fundamental para el estudio y comprensión de los graves desafíos que enfrenta la salud pública en la época actual. Desde esta perspectiva, el presente libro aborda de manera clara y académicamente rigurosa los principios y prácticas fundamentales de la administración de la salud pública. Ofrece a los lectores una visión integral y actualizada de los procesos, herramientas y desafíos que implica la gestión eficaz de la salud a nivel poblacional. Se estudian desde las funciones esenciales de la administración pública y la calidad de la atención al paciente, hasta la formación idónea de los recursos humanos. Este texto constituye una guía indispensable para todos aquellos interesados en contribuir al bienestar y desarrollo de las comunidades a través de una administración eficaz de la salud pública. También se exploran temas emergentes como la ética en el uso de la tecnología sanitaria, los estilos de vida saludables, la equidad en el acceso y la sostenibilidad de los sistemas de salud. La obra está dirigida a estudiantes, profesionales y académicos interesados en profundizar en el conocimiento de la administración de la salud pública y deseen contribuir al desarrollo de políticas y prácticas innovadoras y efectivas en la creación de sistemas de salud más saludables y resilientes para todos. Finalmente, según la perspectiva de los autores de este libro, la administración de la salud pública no se reduce a una mera tarea técnica, sino que, por el contrario, implica un compromiso ético y humano.
Conexões na resolução de problemas matemáticos: estratégias e abordagens docentes
Authors: Hahn Krás Guilherme , De Fraga Sant'Ana Marilaine
Published: September 2024

Este artigo advém de uma pesquisa de mestrado acadêmico que teve o objetivo de analisar as concepções de licenciandos em Matemática acerca da Resolução de Problemas e seus aspectos pedagógicos. A metodologia de pesquisa é qualitativa, e os dados analisados foram produzidos durante dois dos seis encontros propostos para (futuros) professores em um curso de extensão. Neste recorte, analisamos como a resolução de problemas pode ser uma aliada na construção de conexões mentais nas aulas de Matemática, e identificamos quais as conexões foram destacadas pelos participantes da pesquisa. Concluímos que a reflexão sobre Resolução de Problemas pode auxiliar os licenciandos a incorporar a construção de conexões em sua prática pedagógica, portanto, deve ser incentivada no curso de Licenciatura em Matemática.
Automated Disease Detection in Silkworms Using Machine Learning Techniques
Authors: Binson V A  , G Manju
Published: September 2024

Silkworm diseases pose a major threat to the sericulture industry, with early detection remaining a challenge due to limited infrastructure. This study focuses on detecting Grasserie disease, which can rapidly spread in silkworm rearing units, leading to significant economic losses. A novel dataset of 668 healthy and 574 Grasserie-affected silkworm images forms the basis of this research. The study applies machine learning techniques, using the Histogram Oriented Gradient (HOG) feature descriptor combined with Kernel Principal Component Analysis (KPCA) and supervised classifiers. The integration of Support Vector Machines (SVM) with HOG and KPCA achieved high accuracy (93.16%), recall (93.38%), and precision (91.94%), offering a faster, more accurate alternative to manual detection methods. This approach holds great potential for developing real-time, IoT-based diagnostic tools that enable farmers to quickly identify infected silkworms, reducing disease spread and economic losses, and can be extended to other agricultural applications requiring early disease detection.