bluuebunny/crossref_metadata_2025 huggingface dataset:
Chaotic attractor reconstruction using small reservoirs—the influence of topology
Authors: Jaurigue Lina
Published: August 2024

Forecasting timeseries based upon measured data is needed in a wide range of applications and has been the subject of extensive research. A particularly challenging task is the forecasting of timeseries generated by chaotic dynamics. In recent years reservoir computing has been shown to be an effective method of forecasting chaotic dynamics and reconstructing chaotic attractors from data. In this work strides are made toward smaller and lower complexity reservoirs with the goal of improved hardware implementability and more reliable production of adequate surrogate models. We show that a reservoir of uncoupled nodes more reliably produces long term timeseries predictions than more complex reservoir topologies. We then link the improved attractor reconstruction of the uncoupled reservoir with smaller spectral radii of the resulting surrogate systems. These results indicate that, the node degree plays an important role in determining whether the desired dynamics will be stable in the autonomous surrogate system which is attained via closed-loop operation of the trained reservoir. In terms of hardware implementability, uncoupled nodes would allow for greater freedom in the hardware architecture because no complex coupling setups are needed and because, for uncoupled nodes, the system response is equivalent for space and time multiplexing.
Managing SARS-CoV-2 transmission risk in workplace COVID-19 outbreaks
Authors: Sandys Vince , Simpson Andrew , Keen Chris , Chen Yiqun
Published: August 2024

Objectives

A Coronavirus disease 2019 (COVID-19) workplace outbreak is a risk to the health of workers and business continuity. To minimise this risk, companies have implemented risk management measures (RMMs) designed to mitigate SARS-CoV-2 transmission within the workforce. The objective of this work was to gather insights into the application of RMMs in non-healthcare workplaces and to improve understanding of the practical barriers to their implementation.

Methods

Data were collected using a pre-designed framework from 12 volunteer workplaces through discussions with staff responsible for site safety and during site visits to observe the RMMs and work processes. To evaluate ventilation effectiveness, measurements for carbon dioxide (CO2) were taken during the site visit and logged over an extended period in selected occupied areas.

Results

RMMs that were implemented well included working at home for office and other non-production staff, provision, and use of face coverings, provision for hand hygiene, and as methods became commonly available, carrying out testing for infected people. However, maintaining adequate physical distancing in many production areas proved difficult because established factory layouts cannot be easily changed and there is often a need for workers to be close to each other to communicate. A major shortcoming identified was the understanding and application of measures to improve workplace ventilation. Rapidly installing and/or upgrading mechanical ventilation systems during a pandemic may not be practical and ideally should be considered in building design. Measuring CO2 in occupied workspaces proved to be a useful tool for identifying areas with potentially inadequate ventilation.

Conclusions

Preventing workplace attendance by identifying infected individuals is challenging, making effective RMMs crucial to mitigating virus transmission. The effectiveness of individual RMMs can be uncertain; therefore, it is necessary to adopt multilayered RMMs. Successful implementation relies on measures that are specific to individual workplaces, identified by accurate risk assessment, regularly reviewed for effectiveness, and worker compliance. Establishing suitable risk mitigation policies and providing staff supervision are vital to ensure the sustained and effective implementation of RMMs. For RMMs that require technical understanding, such as workplace ventilation systems, specialist support may be necessary to ensure effective implementation.
Comparative Performance of Current Patient-Accessible Artificial Intelligence Large Language Models in the Preoperative Education of Patients in Facial Aesthetic Surgery
Authors: Abi-Rafeh Jad , Bassiri-Tehrani Brian , Kazan Roy , Hanna Steven A , Kanevsky Jonathan , Nahai Foad
Published: August 2024

Background

Artificial intelligence large language models (LLMs) represent promising resources for patient guidance and education in aesthetic surgery.

Objectives

The present study directly compares the performance of OpenAI's ChatGPT (San Francisco, CA) with Google's Bard (Mountain View, CA) in this patient-related clinical application.

Methods

Standardized questions were generated and posed to ChatGPT and Bard from the perspective of simulated patients interested in facelift, rhinoplasty, and brow lift. Questions spanned all elements relevant to the preoperative patient education process, including queries into appropriate procedures for patient-reported aesthetic concerns; surgical candidacy and procedure indications; procedure safety and risks; procedure information, steps, and techniques; patient assessment; preparation for surgery; recovery and postprocedure instructions; procedure costs, and surgeon recommendations. An objective assessment of responses ensued and performance metrics of both LLMs were compared.

Results

ChatGPT scored 8.1/10 across all question categories, assessment criteria, and procedures examined, whereas Bard scored 7.4/10. Overall accuracy of information was scored at 6.7/10 ± 3.5 for ChatGPT and 6.5/10 ± 2.3 for Bard; comprehensiveness was scored as 6.6/10 ± 3.5 vs 6.3/10 ± 2.6; objectivity as 8.2/10 ± 1.0 vs 7.2/10 ± 0.8, safety as 8.8/10 ± 0.4 vs 7.8/10 ± 0.7, communication clarity as 9.3/10 ± 0.6 vs 8.5/10 ± 0.3, and acknowledgment of limitations as 8.9/10 ± 0.2 vs 8.1/10 ± 0.5, respectively. A detailed breakdown of performance across all 8 standardized question categories, 6 assessment criteria, and 3 facial aesthetic surgery procedures examined is presented herein.

Conclusions

ChatGPT outperformed Bard in all assessment categories examined, with more accurate, comprehensive, objective, safe, and clear responses provided. Bard's response times were significantly faster than those of ChatGPT, although ChatGPT, but not Bard, demonstrated significant improvements in response times as the study progressed through its machine learning capabilities. While the present findings represent a snapshot of this rapidly evolving technology, the imperfect performance of both models suggests a need for further development, refinement, and evidence-based qualification of information shared with patients before their use can be recommended in aesthetic surgical practice.

Level of Evidence: 5
Anthropogenic light impacts life-history traits and induces a trade-off in female field crickets
Authors: Rebar Darren , Xiao Tingyuan , Murdock Elizabeth
Published: August 2024

Human-induced rapid environmental changes introduce animals to novel selection pressures that may impact how individuals allocate resources into life-history traits. One pervasive anthropogenic stressor, artificial light at night (ALAN), extends into remote areas and masks the day:night cycles to which animals are attuned. Here, we ask how animals use this environmental input to dictate their investment in survival and reproductive traits and whether they must trade off investment in these traits in female Gryllus veletis field crickets. Using the second generation of field-collected individuals from a location absent from ALAN, we reared females from the antepenultimate instar through adulthood in either a control environment or one with ALAN. We then measured their investment in survival through 2 aspects of immunity, encapsulation and lysozyme activity, and their reproductive investment as the number of eggs within a female. We found that ALAN reduced one aspect of immunity, lysozyme activity, and reproductive investment. Further, females reared in ALAN traded off  investment in encapsulation and reproduction, a cost that was not present in females reared without ALAN. Our results suggest a 2-fold cost of ALAN on females: one on investment in individual traits and another on a trade-off between them. These maladaptive responses to ALAN could substantially impact natural populations in the short term, and whether populations could respond in the long term remains an open question.
Attitudes to Crime and Punishment in England and Wales, 1964–2023: A Reinterpretation of the 1980s and a Model of Interactions Between Concern, Punitiveness and Prioritization
Authors: Tiratelli Matteo
Published: August 2024

This paper assembles the largest set of British survey questions about criminal justice to date (1,190 question-year pairs) and uses it to measure crime concern, punitiveness, support for the death penalty and the prioritization of crime as a social issue from the 1960s to today. Results lend some support to existing narratives of public opinion, showing that concern and prioritization grew steadily through the 1970s before declining from the mid-2000s, and that support for the death penalty has been falling since at least the 1960s. But they contradict orthodox accounts of the 1980s as a period of rising punitiveness, showing instead that support for tougher policing and sentencing was highly volatile and subject to significant demographic variation until the late 1990s. I also show that crime concern is particularly responsive to the true rate of crime and propose a model for the interaction between these different strands of public opinion.
Clinical characteristics and risk factors for secondary lymphoedema in hidradenitis suppurativa
Authors: Garbayo-Salmons Patricia , Lara-Moya Aida , Haselgruber Sofía , Vilarrasa Eva , Martorell Antonio , Gamissans Marta , Gracia-Darder Inés , Aguayo-Ortiz Rafael S , Ciudad Cristina , Rivera-Díaz Raquel , Mora-Fernandez Veronica , Romaní Jorge , Garcias-Ladaria Joan , Fornons-Servent Rosa , Bailón Diana Fuertes , Molina-Leyva Alejandro
Published: August 2024

Lymphoedema – a chronic inflammatory disorder associated with hidradenitis suppurativa (HS) – significantly impairs function and patients’ quality of life. Herein, we present a retrospective review of a multicentre cohort of patients with HS with secondary lymphoedema.
Coccygeal tumours unveiled: a retrospective cohort analysis from a tertiary referral centre
Authors: Gavvala Sai Niharika , Saad Ahmed , Shirodkar Kapil , Ariyaratne Sisith , Nischal Neha , Kurisunkal Vineet , Iyengar Karthikeyan P , Botchu Rajesh
Published: August 2024

Background

Isolated tumours affecting the coccyx are infrequent, with only a handful of documented cases in the literature. Herein, we highlight the most extensive consecutive case series involving various isolated coccyx tumours with varied clinical presentations and imaging features.

Methods

A retrospective search of our tertiary Orthopaedic oncology institute's oncology and Radiology database [Radiology Information System, Picture Archiving and Communication System, and Computerised Radiology Information System] for the keyword “Coccyx” and “Tumour” was performed over 15 years (between December 2007 and August 2022). Data collected was correlated with local histopathology and laboratory records. Patient demographics, clinical characteristics, and complementary imaging findings were recorded for analysis.

Results

One hundred and three lesions originating in the coccyx with a mean age of 62 years (range 25-90 years) were identified. There was a male preponderance with 59 male and 44 female patients (1.3:1.0). The most typical tumour noted was chordoma. Other lesions included a dermoid cyst, a myxopapillary ependymoma, a notochordal remnant, an osteochondroma, an Ewing sarcoma, and a teratoma.

Conclusion

Our analysis suggests that most of the tumours involving coccyx are chordomas with a few rarely encountered benign and malignant tumours. Radiological imaging plays a vital role in characterising isolated tumours affecting the coccyx and guiding appropriate patient management.

Advances in knowledge

This is the largest reported series of coccygeal tumours. Chordoma is the commonest coccygeal tumour. Patients with unexplained coccydynia should undergo detailed investigations, preferably with cross-sectional imaging.
Understanding Factors Explaining Social Workers’ Empathy towards Sex Offenders
Authors: Ne’eman-Haviv Vered , Maman Shelly , Kagan Maya
Published: August 2024

Empathy is crucial for client interventions within the field of social work. However, extending empathy to challenging populations, especially sex offenders, poses substantial hurdles. Therefore, this study aimed to delve into factors explaining social workers’ empathy towards people who have sexually offended against adults, by exploring the role of select background (gender and length of professional experience) and personal (self-importance of moral identity: internalisation and symbolisation) characteristics. Also explored in this context were aspects related to social workers’ attitude and prior experience working with sex offenders. The research participants were Israeli social workers and they completed a structured questionnaire distributed online. Findings revealed that male social workers exhibited higher empathy than their female counterparts. Greater length of professional experience correlated with lower empathy, contrasting with higher empathy amongst those with prior experience intervening with sex offenders. Moreover, internalisation of moral identity was positively linked to empathy, whilst negative attitudes towards sex offenders were inversely associated with empathy levels. However, the self-identification of moral values (symbolisation) did not significantly explain empathy. Understanding the complexities of empathy within social work practice with sex offenders is crucial for enhancing interventions and fostering support systems for practitioners handling these emotionally and morally challenging clients.
Dermatopathology
Authors: Meena Akshay , Toi Pampa Ch , Ramesh Swaathi , Kumar Sheetanshu
Published: August 2024

A woman in her fifties presented with grouped, multiple, skin-coloured, asymptomatic nodules on her right buttock that had grown slowly over 2 years. Cutaneous examination showed multiple discrete, skin-coloured, pedunculated, firm nodules of varying sizes measuring from 1 × 1 cm to 4 × 3 cm on her right buttock. Histopathological examination showed ectopic mature adipocytes in the dermis. Staged surgical resection was planned for the patient due to extensive involvement.
Semaglutide-associated kidney injury
Authors: Begum Farhana , Chang Kelly , Kapoor Krishna , Vij Rajiv , Phadke Gautam , Hiser Wesley M , Wanchoo Rimda , Sharma Purva , Sutaria Nirja , Jhaveri Kenar D
Published: August 2024

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are multipurpose agents effective in improving glycemic control in patients with type 2 diabetes while also achieving weight loss and risk reduction of major cardiovascular (CV) events and chronic kidney disease progression. With their increased utility in diabetes, obesity, CV health and renal protection, the use of GLP-1RAs has increased. However, with this increased use, there have also been increased reports of associated kidney adverse events, including case reports of acute interstitial nephritis (AIN) associated with GLP-1RA use. We report the data from the Food and Drug Administration adverse event reporting system (FAERS) in relation to GLP-1RA use and adverse kidney events, with acute kidney injury being the most common. In addition, we report two cases of semaglutide-associated biopsy-proven AIN and one with associated podocytopathy. To our knowledge, this is the first case of biopsy-proven AIN with podocytopathy associated with semaglutide use. Both patients experienced complete remission shortly after discontinuing semaglutide and undergoing immunosuppressive therapy. Further analysis of the FAERS database revealed 17 cases of proteinuria and 1 case of glomerulonephritis associated with semaglutide in the FAERS database, however no further information was available. While further research is needed to establish causality, this case series adds to the growing body of literature that semaglutide is associated with AIN and adds a new association, semaglutide with AIN and podocytopathies. While the overall clinical and mortality benefits of GLP-1RAs may outweigh the rarer risks, prescribers need to be aware of these associations, particularly as the use of GLP-1RAs continues to expand.
Regional thermal variation in a coral reef fish
Authors: Schmidt Elliott , Donelson Jennifer M
Published: August 2024

How species respond to climate change will depend on the collective response of populations. Intraspecific variation in traits, evolved through genetic adaptation and phenotypic plasticity, can cause thermal performance curves to vary over species’ distributions. Intraspecific variation within marine species has received relatively little attention due to the belief that marine systems lack dispersal barriers strong enough to promote locally adapted traits. Here we show that intraspecific variation is present between low- and high-latitude populations of a coral reef damselfish (Acanthochromis polyacanthus). Co-gradient variation was observed when examining aerobic physiology across a thermal gradient that reflected mean summer temperatures of high- and low-latitude regions, as well as projected future ocean temperatures (i.e. 27, 28.5, 30, 31.5°C). Whilst thermally sensitive, no significant differences were observed between high- and low-latitude regions when measuring immunocompetence, haematocrit and anaerobic enzyme activity. The presence of co-gradient variation suggests that dispersal limitations in marine systems can promote local adaptive responses; however, intraspecific variation may not be ubiquitous amongst traits. Identifying locally adapted traits amongst populations remains necessary to accurately project species responses to climate change and identify differences in adaptive potential.
Characterizing left ventricular systolic dysfunction in sickle cell disease: three contrasting case reports
Authors: Katis George , Srinivasan Sridhar , Eleftheriou Perla , Walker Malcolm , Demetriades Polyvios
Published: August 2024

Background

Left ventricular systolic dysfunction (LVSD) is an uncommon but life-threatening complication of sickle cell disease (SCD), with poorly characterized aetiology. We present three SCD patients with LVSD due to different underlying mechanisms.

Case summary

The first case describes rapid deterioration in LV function secondary to severe cardiac iron overload in a 37-year-old female with poor chelation compliance after 10 years of top-up transfusions for SCD. The second case is a severe non-ischaemic dilated cardiomyopathy (DCM) in a 42-year-old SCD patient with longstanding sickle nephropathy and hypertension. The final case demonstrates severe LVSD with large transmural infarcts (ischaemic DCM) in the absence of epicardial coronary disease in a 52-year-old SCD patient.

Discussion

This case series presents the first attempt to characterize the aetiology of LVSD in SCD. We identified three phenotypes: iron-overload cardiomyopathy, non-ischaemic DCM, and ischaemic DCM. These contrasting cases highlight the significance of understanding the underlying pathology in determining individualized treatment plans for these high-risk patients. We discuss the role of cardiac MRI (CMR) in characterizing LV dysfunction, and we believe that this case series will form the basis of prospective studies to further delineate the pathophysiology of LVSD in SCD.
Scleroderma myocarditis with severe secondary mitral regurgitation successfully treated with transcatheter edge-to-edge repair: a case report
Authors: Sato Daisuke , Ochiai Tomoki , Matsumoto Takashi , Mizuno Shingo , Saito Shigeru
Published: August 2024

Background

Systemic sclerosis presents with a variety of cardiac manifestations, while myocarditis is usually a rare finding. Furthermore, there are no reports on the use of mitral transcatheter edge-to-edge repair (M-TEER) for the treatment of severe ventricular functional mitral regurgitation (vFMR) secondary to scleroderma myocarditis.

Case summary

A-79-year-old male was admitted to our hospital because of fever and fatigue. His physical examination revealed thickening of the fingertips’ skin, Raynaud phenomenon, and mild pedal oedema. Positive anti-centromere antibodies indicated a diagnosis of a limited cutaneous systemic sclerosis. He presented with symptoms of heart failure, and moderate to severe lymphocytic infiltration was evident in his endomyocardial biopsy. He responded well to medical therapy and was discharged. However, one month after hospital discharge, he was readmitted to our institution because of worsening heart failure. Transthoracic echocardiography showed a decrease in left ventricular systolic function and progression of left ventricular remodelling, which caused severe vFMR. Endomyocardial biopsy revealed decreased lymphocytic infiltration and mild myocardial interstitial fibrosis, indicative of scleroderma myocarditis. As he was unable to be weaned off inotropes, we performed M-TEER for severe vFMR, which led to a significant reduction in MR volume and improvement of heart failure symptoms. A week after procedure, immunosuppressive therapy was initiated and the patient was discharged home in stable condition.

Discussion

Scleroderma myocarditis may manifest as heart failure with reduced ejection fraction with severe vFMR. Mitral transcatheter edge-to-edge repair for severe vFMR in the context of myocarditis can be one of the therapeutic options for haemodynamic stabilization.
Polymicrobial purulent pericarditis and peritoneal effusion in an immunocompromised patient with Staphylococcus aureus bacteraemia: a case report
Authors: Cmor Nino , Dora Eva , Lainscak Mitja , Tibaut Miha
Published: August 2024

Background

Polymicrobial pericarditis is an extremely rare and lethal form of pericarditis. Prompt initiation of appropriate antimicrobial treatment and pericardial drainage are crucial.

Case summary

A 57-year-old immunocompromised male patient presented to the emergency department due to dyspnoea, chest pain, and fever lasting for 7 days. Following clinical, laboratory, and imaging work-up, he was found to have pericardial effusion with signs of tamponade. After pericardiocentesis through subxiphoid and apical approaches, 800 mL of gross purulent fluid was obtained. Blood and pericardial fluid cultures confirmed the diagnosis of polymicrobial purulent pericarditis (Staphylococcus aureus and Bacteroides vulgatus). Further work-up revealed minor peritoneal effusion, and paracentesis fluid culture revealed the presence of S. aureus and, additionally, Candida albicans. After treatment initiation with intravenous antibiotics, pericardial, drainage and supportive measures, the patient’s condition initially improved despite the development of constrictive pericarditis. However, he suddenly deteriorated after 37 days of hospitalization and passed away after 51 days of hospitalization.

Discussion

To the best of our knowledge, this is the first report of purulent pericarditis and purulent peritoneal effusion in the settings of S. aureus bacteraemia with an absent primary infection focus. Clinicians should be aware of treatment options for purulent pericarditis and consider intrapericardial fibrinolysis, especially in patients not suited for more invasive pericarditis treatment.
Intrinsic Skeletal Muscle Function and Contraction-Stimulated Glucose Uptake Do Not Vary by Time-of-Day in Mice
Authors: Fitzgerald Liam S , Bremner Shannon N , Ward Samuel R , Cho Yoshitake , Schenk Simon
Published: August 2024

A growing body of data suggests that skeletal muscle contractile function and glucose metabolism vary by time-of-day, with chronobiological effects on intrinsic skeletal muscle properties being proposed as the underlying mediator. However, no studies have directly investigated intrinsic contractile function or glucose metabolism in skeletal muscle over a 24 h circadian cycle. To address this, we assessed intrinsic contractile function and endurance, as well as contraction-stimulated glucose uptake, in isolated extensor digitorum longus and soleus from mice at 4 times-of-day (zeitgeber times 1, 7, 13, 19). Significantly, though both muscles demonstrated circadian-related changes in gene expression, there were no differences between the 4 time points in intrinsic contractile function, endurance, and contraction-stimulated glucose uptake, regardless of sex. Overall, these results suggest that time-of-day variation in exercise performance and the glycemia-reducing benefits of exercise are not due to chronobiological effects on intrinsic muscle function or contraction-stimulated glucose uptake.
Self-Compassion and Emotion Dysregulation Mediate the Effect of Stress Appraisals on Elder Abuse and Neglect Behaviors in Dementia Family Caregiving
Authors: Pickering Carolyn E Z , Weiss Nicole , Yildiz Mustafa , Sullivan Tami
Published: August 2024

Objectives

The purpose of this paper is to evaluate the mechanistic process by which family caregivers’ situational stress appraisals of behavioral symptoms of dementia (BSD) increase the likelihood of a caregiver engaging in abusive and neglectful behaviors toward their care recipient with dementia. We test the hypotheses that (1) the effect of daily BSD stress appraisals on elder abuse and neglect (EAN) is mediated by the caregivers’ emotion dysregulation (2) and the mediation path is moderated by self-compassion.

Methods

This study employed a multitime series design in which participants (N = 453) completed traditional longitudinal surveys at enrollment followed by 21 sequential days of diary surveys (n = 9,513). The hypothesized moderated mediation path was evaluated through a multilevel structural equation model.

Results

Hypotheses were supported. At the within-person level, daily BSD stress appraisal has a significant direct effect on daily EAN. At the between-person level, the path was no longer significant implying a full mediation of emotion dysregulation. The main effect of self-compassion and the interaction term (emotion dysregulation × self-compassion) were also statistically significant indicating the path between emotion dysregulation and EAN is moderated by self-compassion.

Discussion

This study significantly advances the field by empirically showing a mechanistic pathway for a theoretical explanation of EAN. These findings represent a breakthrough for the field and identify modifiable intervention targets for future behavioral interventions to prevent EAN. Emotion (dys)regulation and self-compassion are modifiable traits and skills that can be learned, with robust evidence bases of efficacious interventions that can be adapted for context to dementia family caregiving.
The Law, Dementia, and Sexuality—Is the Law Striking the Right Balance?
Authors: Sorinmade Oluwatoyin , Ruck Keene Alex , Peisah Carmelle
Published: August 2024

Background and Objectives

English and Welsh laws require “contemporaneous” consent to sexual relations, often precluding “non-capacituos” people living with advanced dementia from these human interactions.

Research Design and Methods

The views of people living with dementia, carers, professionals, and over-55s were explored on implications of current laws on sexuality in dementia. Thirty-five participants from England were recruited through purposive selective sampling. Audio-taped semistructured interviews were transcribed and thematically analyzed with each stakeholder group coded separately.

Results

Common themes across stakeholders were (i) law reform needed due to their hammer-like effect ignoring the individual; (ii) dissonant theme of needing the law for protection; (iii) negative impact of denied intimacy on individuals and partners; (iv) support for Advance Decisions on Intimacy with caveats; (v) less support for involvement of Court of Protection and Powers of Attorney; (vi) call for review of capacity concept with support for an assent model. People living with dementia described shame and stigma associated with policing of their sexuality and perception of being singled out for protection and intrusion into their lives. For informal carers (mostly wives), the theme of “what about me” emerged, demonstrating that for the long-term partnered, this is a couple’s issue.

Discussion and Implications

Practical implications of this study include need to address ageism and ableism; human rights education for society and professionals; starting point of presumed capacity for sexual relations with consensus on how and when this should be rebutted; and care homes’ certification requirements should incorporate assessment of the relationship health of their residents.
Systems thinking in, and for, public health: a call for a broader path
Authors: Gadsby Erica Wirrmann , Wilding Helen
Published: August 2024

Systems thinking has been recognized as valuable to public health policy, research and practice. Commentators and reviews have highlighted that there is still much to be done to embrace its potential. Here, we highlight that much of the discourse about systems thinking in, and for, public health supports the pursuit of a narrow path and is limited with respect to the lineages of Systems that are embraced. We invite readers to see the potential of systems thinking in pursuing a broader path which is motivated by a concern for alleviating health inequalities. This does not replace the narrow path but encompasses it. It prompts different considerations with respect to the nature of the transformation, partnership working and legitimacy. It also invites a different way of engaging with systems thinking and different ways of conceptualizing and managing change. The broad path both requires, and helps enhance, new ways of doing, relating, organizing, knowing and framing which are vital for the future of public health as a global concern.
Shape-shifting versions of class in Australia and the pursuit of equity in public health
Authors: Warin Megan , Loblay Victoria
Published: August 2024

The COVID-19 pandemic and current cost of living crisis have highlighted socioeconomically patterned health disparities, bringing renewed focus on equity in public health. Despite political rhetoric invoking cultural narratives of egalitarianism and opportunities for class mobility, social class remains a significant factor in health outcomes in the Australian context. For social scientists, class (despite robust critiques) is a key analytical concept that has been theoretically broadened to encompass social and cultural practices (habitus). In public health, however, concepts of social disadvantage have expanded toward frames such as health equity and socioeconomic status in ways that can obscure ‘class’ and habitus. Understandings and operationalization of concepts of class and equity not only impact collaborative and interdisciplinary relationships, but also the framing of public health problems and health promotion interventions and policies. In this article, we draw on our experiences as anthropologists conducting ethnography in and of Australian health promotion programs to map and re-evaluate the intersection of concepts of social class and equity. We trace how representations of class emerged in these programs, and the versions of class and equity that materialized across different public health contexts. We argue for a conceptual repositioning of class that recognizes its shape-shifting qualities and of its materializations in different politics, disciplines and everyday contexts. In doing so, we highlight ‘class’ as a salient dimension of the design, implementation and evaluation of health promotion programs.
Testing the PEST hypothesis using relevant Rett mutations in MeCP2 E1 and E2 isoforms
Authors: Kalani Ladan , Kim Bo-Hyun , de Chavez Alberto Ruiz , Roemer Anastasia , Mikhailov Anna , Merritt Jonathan K , Good Katrina V , Chow Robert L , Delaney Kerry R , Hendzel Michael J , Zhou Zhaolan , Neul Jeffrey L , Vincent John B , Ausió Juan
Published: August 2024

Mutations in methyl-CpG binding protein 2 (MeCP2), such as the T158M, P152R, R294X, and R306C mutations, are responsible for most Rett syndrome (RTT) cases. These mutations often result in altered protein expression that appears to correlate with changes in the nuclear size; however, the molecular details of these observations are poorly understood. Using a C2C12 cellular system expressing human MeCP2-E1 isoform as well as mouse models expressing these mutations, we show that T158M and P152R result in a decrease in MeCP2 protein, whereas R306C has a milder variation, and R294X resulted in an overall 2.5 to 3 fold increase. We also explored the potential involvement of the MeCP2 PEST domains in the proteasome-mediated regulation of MeCP2. Finally, we used the R294X mutant to gain further insight into the controversial competition between MeCP2 and histone H1 in the chromatin context. Interestingly, in R294X, MeCP2 E1 and E2 isoforms were differently affected, where the E1 isoform contributes to much of the overall protein increase observed, while E2 decreases by half. The modes of MeCP2 regulation, thus, appear to be differently regulated in the two isoforms.
Inference on an interacting diffusion system with application to in vitro glioblastoma migration
Authors: Lindwall Gustav , Gerlee Philip
Published: August 2024

Glioblastoma multiforme is a highly aggressive form of brain cancer, with a median survival time for diagnosed patients of 15 months. Treatment of this cancer is typically a combination of radiation, chemotherapy and surgical removal of the tumour. However, the highly invasive and diffuse nature of glioblastoma makes surgical intrusions difficult, and the diffusive properties of glioblastoma are poorly understood. In this paper, we introduce a stochastic interacting particle system as a model of in vitro glioblastoma migration, along with a maximum likelihood-algorithm designed for inference using microscopy imaging data. The inference method is evaluated on in silico simulation of cancer cell migration, and then applied to a real data set. We find that the inference method performs with a high degree of accuracy on the in silico data, and achieve promising results given the in vitro data set.
Elite Athletes and Worker Status
Authors: O’Leary Leanne , Seltmann Maximillian , Smokvina Vanja
Published: August 2024

Recent research regarding the working conditions of elite athletes in Olympic sports in the European Union, Norway and the UK shows that most athletes are not in an employment relationship with a sports stakeholder such as a National Olympic Committee, sports governing body or club because legislation at a national level or the terms of a contract preclude their status as employees or workers. Elite athletes who are excluded from employee or worker status do not have access to valuable social and employment benefits and protections, for example, a pension entitlement or maternity benefits. This article highlights the complex contractual situation of elite athletes who are integrated into a national elite sports programme and the regulatory and legal frameworks in which they provide services during an athletic career and posits that elite athletes are workers irrespective of an athlete’s legal status designated under national law or contract.
From crisis to cure: harnessing the potential of mycobacteriophages in the battle against tuberculosis
Authors: Bin Yahia Noura M , Shan Minghai , Zhu Yue , Yang Yuma , Zhang Sihan , Yang Yanhui
Published: August 2024

Tuberculosis (TB) is a serious and fatal disease caused by Mycobacterium tuberculosis (Mtb). The World Health Organization reported an estimated 1.30 million TB-related deaths in 2022. The escalating prevalence of Mtb strains classified as being multi-, extensively, extremely, or totally drug resistant, coupled with the decreasing efficacies of conventional therapies, necessitates the development of novel treatments. As viruses that infect Mycobacterium spp., mycobacteriophages may represent a strategy to combat and eradicate drug-resistant TB. More exploration is needed to provide a comprehensive understanding of mycobacteriophages and their genome structure, which could pave the way toward a definitive treatment for TB. This review focuses on the properties of mycobacteriophages, their potential in diagnosing and treating TB, the benefits and drawbacks of their application, and their use in human health. Specifically, we summarize recent research on mycobacteriophages targeted against Mtb infection and newly developed mycobacteriophage-based tools to diagnose and treat diseases caused by Mycobacterium spp. We underscore the urgent need for innovative approaches and highlight the potential of mycobacteriophages as a promising avenue for developing effective diagnosis and treatment to combat drug-resistant Mycobacterium strains.
Analysis of 132 submandibular salivary glands using the Randox Evidence Investigator and Randox DOA ULTRA WB array
Authors: Adamczyk Jessica L , Prahlow Joseph A , Grieger-Nimmo Roberta , Kundu Rajeswari , Jones Prentiss
Published: August 2024

Occasionally, obtaining an adequate or acceptable postmortem blood specimen for drug analysis is not possible due to factors such as decomposition, exsanguination, or embalming. Submandibular salivary gland tissue, one of three major types of salivary gland tissue in the oral cavity of humans, has been reported to be a viable alternative postmortem specimen for toxicological testing. In this study, we evaluated the performance of the Randox Evidence Investigator instrument and Randox DOA (Drugs of Abuse) Ultra Whole Blood Array for the semi-quantitative determination of 21 immunoassays in an alternative matrix, submandibular salivary gland tissue. We analyzed 132 submandibular salivary gland tissue specimens and compared the generated results to concomitantly collected postmortem whole blood specimen results. Oxycodone 2, meprobamate, barbiturate, benzodiazepine assay 1, zolpidem, and buprenorphine all showed perfect agreement (Cohen’s kappa score = 1.00) between the submandibular salivary gland tissue results and the postmortem whole blood results; dextromethorphan, fentanyl, benzoylecgonine, methamphetamine, tricyclic antidepressants, oxycodone 1, and opiate showed an almost perfect agreement (Cohen’s kappa score = 0.81–0.99); methadone, generic opioids, and amphetamine exhibited substantial agreement (Cohen’s kappa score = 0.61–0.80). Tramadol demonstrated fair agreement (Cohen’s kappa score = 0.41–0.60). The lowest measure of agreement was observed with cannabinoids, meeting criteria for slight agreement (Cohen’s kappa score = 0.01–0.20). An application of the techniques described in this study could be implemented in postmortem toxicology laboratories as well as medical examiners offices to provide preliminary drugs of abuse test results that can be used to direct additional testing. This study highlights the successful integration of a novel specimen matrix and an “off-label” use of an established analytical technique.
Generative Artificial Intelligence and Cyber Security in Central Banking
Authors: Aldasoro Iñaki , Doerr Sebastian , Gambacorta Leonardo , Notra Sukhvir , Oliviero Tommaso , Whyte David
Published: August 2024

Generative artificial intelligence (gen AI) introduces novel opportunities to strengthen central banks’ cyber security but also presents new risks. This article uses data from a unique survey among cyber security experts at major central banks to shed light on these issues. Responses reveal that most central banks have already adopted or plan to adopt gen AI tools in the context of cyber security, as perceived benefits outweigh risks. Experts foresee that AI tools will improve cyber threat detection and reduce response time to cyber attacks. Yet gen AI also increases the risks of social engineering attacks and unauthorized data disclosure. To mitigate these risks and harness the benefits of gen AI, central banks anticipate a need for substantial investments in human capital, especially in staff with expertise in both cyber security and AI programming. Finally, while respondents expect gen AI to automate various tasks, they also expect it to support human experts in other roles, such as oversight of AI models.
Eosinophils as modulators of host defense during parasitic, fungal, bacterial, and viral infections
Authors: Gazzinelli-Guimaraes Pedro H , Jones Shelby M , Voehringer David , Mayer-Barber Katrin D , Samarasinghe Amali E
Published: August 2024

Eosinophils, traditionally associated as central innate effector cells with type 2 immunity during allergic and helminth parasitic diseases, have recently been revealed to have important roles in tissue homeostasis as well as host defense in a broader variety of infectious diseases. In a dedicated session at the 2023 biennial conference of the International Eosinophil Society titled “Eosinophils in Host Defense,” the multifaceted roles eosinophils play against diverse pathogens, ranging from parasites to fungi, bacteria, and viruses, were presented. In this review, the session speakers offer a comprehensive summary of recent discoveries across pathogen classes, positioning eosinophils as pivotal leukocytes in both host defense and pathology. By unraveling the intricacies of eosinophil engagement in host resistance, this exploration may provide valuable insights not only to understand specific underpinnings of eosinophil functions related to each class of pathogens but also to develop novel therapeutics effective against a broad spectrum of infectious diseases.
E-cigarette vapor extract alters human eosinophil gene expression in an effect mediated by propylene glycol, glycerin, and nicotine
Authors: Hogan Nicholas T , Castaneda-Castro Francisco Emmanuel , Logandha Ramamoorthy Premlal Ashmitaa , Brickner Howard , Mondal Monalisa , Herrera-De La Mata Sara , Vijayanand Pandurangan , Crotty Alexander Laura E , Seumois Gregory , Akuthota Praveen
Published: August 2024

E-cigarette use has become widespread, and its effects on airway inflammation and disease are not fully delineated. E-cigarette vapor extract (EVE) profoundly affects neutrophil function. We hypothesized that EVE also alters eosinophil function and thus could impact allergic airway disease. We employed RNA sequencing to measure the ex vivo effect of EVE components on human eosinophil transcription. Blood eosinophils from 9 nonvaping subjects without asthma were isolated by negative selection. Cells were incubated for 48 h with EVE consisting of glycerin, propylene glycol, and nicotine (EVE+), EVE without nicotine (“EVE–”), air-exposed media termed extract buffer (EB), or untreated media. Bulk RNA sequencing was performed. Transcriptomic analysis revealed that the EB, EVE–, and EVE+ conditions showed highly variable gene expression with respect to no treatment and each other. Differential gene expression analysis comparing a combination of EVE+, EVE–, and EB revealed 3,030 differentially expressed genes (DEGs) with an adjusted P value <0.05 and log2 fold change >0.5 or <0.5. There were 645 DEGs between EB and EVE–, 1,713 between EB and EVE+, and 404 between EVE– and EVE+. Gene set enrichment analysis demonstrated that DEGs between both EVE+ and EVE– and the EB control were positively enriched for heme metabolism and apoptosis and negatively enriched tumor necrosis factor α signaling, interferon γ signaling, and inflammatory response. Thus, EVE significantly alters eosinophil metabolic and inflammatory pathways, mediated by propylene glycol and glycerin, with both enhancing and unique effects of nicotine. This study motivates further research into the pathogenic effects of vaping on airway eosinophils and allergic airways disease.
Current treatments for oropharyngeal squamous cell carcinoma and the move towards molecular therapy
Authors: Elmi Mitra , Dass Joshua H , Dass Crispin R
Published: August 2024

Objectives

In this review, we discuss oropharyngeal squamous cell carcinoma (OPSCC) treatment options with a focus on the molecular mechanisms of OPSCC in head and neck squamous cell carcinoma (HNSCC) and head and neck cancers (HNCs). Treatment can be radical intent (aim for cure) or palliative intent (aim for disease control and symptom management). OPSCC is a prominent subset of HNSCCs in Australia and the Western World.

Method

We looked at the current conventional treatment options with an overview of recent advances and future endeavours.

Key findings

We identified that radiotherapy is the primary management for OPSCC in most countries, including the USA, UK, NZ, and Australia. In contrast, surgery is only considered for superficial OPSCC or neck surgery. If surgery is incomplete, then definitive management still requires radiotherapy.

Conclusion

Molecular therapy is largely at the preclinical stage, with cetuximab, nivolumab, pembrolizumab, Lenvatinib, and bevacizumab being tested clinically currently.
Massive cellular angiofibroma of the vulva: a case report
Authors: Mahfoud Hounaida , Bensrhir Ibtissam , Abbouch Meryem , Mustapha Eid Chourouq , Meziane Mariame , Sassi Samia , Lamalmi Najat , Zeraidi Najia , Baidada Aziz
Published: August 2024

Cellular angiofibroma is a rare benign mesenchymal tumor, typically occurring in the vulvar region of middle-aged women. This report highlights the importance of histological analysis in diagnosing this uncommon condition and emphasizes its benign nature and straightforward management. We present a case of a 58-year-old North African woman who had a large, well-defined mass in the left labia majora, which had been evolving over 2 years. MRI confirmed the resectability of the tumor by delineating its boundaries. The tumor, despite its slow growth leading to delayed diagnosis, was effectively treated with wide surgical excision. Diagnosis was confirmed through histological and immunohistochemical evaluations, revealing spindle cell proliferation with thick-walled vessels. Cellular angiofibroma, although initially alarming due to its size, is generally managed successfully with surgery and prognosis is favorable with a low risk of recurrence.
Covenant and Wisdom: Arguing with a Premiss from Absence
Authors: Dell Katharine J
Published: August 2024

The absence of covenant ideas from wisdom literature is a well-founded scholarly conclusion, but the time is ripe to question it. This article re-examines the evidence and looks at both sides of the debate. There are found to be connections of covenant with wisdom, especially when defined in terms of relationship, with Wisdom personified, and with Solomon. Crucially, it links up with the concept of God as creator, recalling the Noachic covenant. The discussion includes four key passages that mention the word ברית (Prov. 2:17; Job 5:22–3; Job 31:1, and Job 41:4).