bluuebunny/crossref_metadata_2025 huggingface dataset:
Concealed left hepatic artery injury with liver trauma
Authors: Joy Rejana Rachel , Valsalan Abhijith , Kavalakat Alfie J. , Kuriakose Aneesh M. , Suresh Mayyattil V.
Published: June 2022

Injury to the liver accounts for 3%–10% of blunt abdominal trauma injuries. Majority of these injuries are currently managed nonoperatively. Hepatic artery or portal triad injuries are less frequent. However, the mortality rates with portal triad injuries and with combined injuries are high. Hence, identifying these injuries are important to the trauma team to proceed with optimal management. We present the case of a patient with concealed hepatic artery injury with liver trauma who was managed by laparotomy and vessel repair. We highlight the importance of recognising the clinical and radiological signs that indicate the possibility of hepatic artery injuries. This case report aims at improving awareness of hepatic artery injuries that may occur alone or in association with liver injuries and their management.
Platelet concentrates: An elixir of periodontal regeneration
Authors: Chandel Deepika , Sinha Aditya , Chauhan Shailendra Singh , Sharma Satendra , Garg Ankita
Published: June 2022

Platelet concentrates (PCs) such as platelet-rich plasma and platelet-rich fibrin (PRF) are commonly used in various surgical procedures in medical as well as dental fields, oral and maxillofacial surgery, plastic surgery and sports medicine. The main motive is to elicit all the components of a blood sample that can be used to promote healing and regeneration. PCs came a long way since their existence in 1954 from titanium-PRF, advanced-PRF and injectable-PRF being introduced newly. These concentrates have been successfully applied in periodontal regenerative procedures and implantology. However, the preparation techniques, methodology, standing time, transfer process, temperature of centrifuge, vibration and other factors tend to produce mixed results. This review is designed to sort out all the confusions by introducing the exact origination of PCs, preparation techniques along with recent trends and clinical applications in periodontology.
Opportunistic infections in patients with haematological malignancies in Nigeria
Authors: Ekeng Bassey Ewa , Akaba Kingsley , Ide Christian , Oladele Rita
Published: June 2022

Haematological malignancies (HM) are common clinical conditions encountered in Nigeria. Patients with haematological cancers are immunocompromised and as such are at risk of invasive fungal infections (IFIs). The objective of this review was to highlight the paucity of data on IFIs in patients with HM in Nigeria and recommendations on the way forward. A literature search for publications from Nigeria on HM including case reports and reviews from 1961 to 2021 yielded 76 publications of which only 9 (11.8%) reported infections in HM. Eight publications documented infection by viruses while only one publication documented bacterial infection. Viruses (73/93, 78.5%) including human cytomegalovirus (n = 19, 20.4%), Hepatitis B virus (n = 15, 16.1%), hepatitis C virus (n = 6, 6.5%) and human T-lymphotropic virus (n = 2, 2.2%) were the commonest causative agents of infections with HIV (n = 31, 33.3%) as the predominant pathogen. Mycobacterium tuberculosis was the only bacterial agent (n = 20, 20.5%). Reports on infections in patients with HM were mostly from the South-South (n = 4), followed by South West (n = 3) and North Central (n = 2). There were no data on IFIs. The limited information on the profile of IFIs in patients with HM in Nigeria may account for the high morbidity and mortality rates associated with HM. Prospective studies should be carried out as a matter of urgency to bridge this knowledge gap.
Association of Knowledge, Perception, and Fear Regarding COVID-19 with the Socioeconomic Status of Patients Attending a Dental Hospital in Belagavi District
Authors: Deepika V. , Sankeshwari Roopali Manohar , Ankola Anil V. , Jalihal Sagar , Choudhury Abhra Roy , Deshpande Apurva P
Published: June 2022

Background:

The COVID-19 pandemic has resulted in a significant loss of human life over the world and poses an unparalleled public health threat. As a result, it is critical to comprehend the patients' perspectives and knowledge on the subject.

Aim:

The aim of the study is to assess the knowledge, fear, and perception regarding COVID-19 among patients attending a dental hospital in Belagavi, India, and to compare it with their socioeconomic status using Kuppuswamy scale 2019.

Materials and Methods:

A cross-sectional questionnaire study was conducted among patients attending the dental hospital during the complete lockdown. A total of 170 respondents were included in the study. A self-designed, validated questionnaire with 14 closed-ended questions was prepared, among which 11 questions were knowledge based, two were on perception, and one on fear. Data were entered into Microsoft Excel and analyzed using the SPSS version 25.P≤ 0.05 was considered statistically significant.

Results:

A total of 170 participants were included in the study. The age ranged between 26 and 80 years. Majority of the population (95%) knew the symptoms of COVID-19 and the measures to be taken to prevent it. An association was found between participants' educational status and their knowledge regarding signs and symptoms of novel coronavirus (P = 0.005). Most of the study participants were not aware of the distance to be kept during social distancing (45.8%). Lockdown caused financial burden to more than 70% of the study participants.

Conclusion:

Nonliterate youth and adults were most likely to be the hardest hit by educational, social, and economic impacts of COVID-19.
Effect of COVID-19 driven lockdown on social contact pattern in Puducherry, India: A longitudinal study
Authors: Kar SS , Krishnamoorthy Y , Sivanantham P , Anandraj J , Gnanadhas J
Published: June 2022

Objective:

This study was undertaken to assess the change in social contact and transmission dynamics among adults in the Puducherry district during the different phases of country-wide lockdown.

Methods:

Adults aged 18–69 years in Puducherry were assessed for frequency and duration of contacts in the following time points: prior to lockdown (March 2020), during lockdown, immediate post-lockdown (April, June 2020), and seven months post-lockdown (February 2021). Adjusted incidence rate ratios (aIRR) were obtained using a generalized estimating equation. We also assessed the exponential trajectory of the time-varying reproduction number (Rt) during and after lockdown.

Results:

Compared to pre-lockdown phase, frequency of social contacts during 1st week, 4th week of lockdown, and immediate post-lockdown were reduced by 89% (aIRR = 0.11; 95% CI: 0.09–0.13), 40% (aIRR = 0.60; 95% CI: 0.52–0.69) and 91% (aIRR = 0.09; 95% CI: 0.07–0.10) respectively. However, the decline was not statistically significant at seven months post-lockdown. Correspondingly, we observed an initial spike in Rt during the lockdown phase followed by a gradual decline during the immediate post-lockdown phase. However, seven months post-lockdown, Rt has increased again.

Conclusion:

The study showed high compliance to the lockdown measures in Puducherry during the lockdown and immediate post-lockdown periods. However, as the lockdown measures were relaxed, the contact rate returned to the pre-lockdown state.
Lunar lenses – Acquired lens colobomas
Authors: Choudhary S , Katoch D , Pandav SS , Kaushik S
Published: June 2022

Acquired lens colobomas secondary to ocular surgeries are scarcely described in the literature. We describe two cases of acquired lens coloboma in two infants with glaucoma who underwent ocular surgery. The coloboma in the first case was likely because of direct trauma to the lens zonules during an optical iridectomy with a vitrectomy cutter, resulting in localized loss of zonules and consequently localized lens coloboma. The coloboma in the second case was noticed during examination under anesthesia after scleral buckling and cryopexy for retinal detachment. The cause for coloboma development in this case could be disruption of the lens zonules because of stretching of the globe after scleral buckle surgery or because of injury to zonules during scleral buckling and the cryopexy procedure.
Impact of boko haram insurgency on the nutritional status of two communities in Gulani Local Government Area, Yobe State, Nigeria
Authors: Musab Maina , Otovwe Agofure
Published: June 2022

The Boko Haram insurgency has consistently posed a threat to the lives of residents in the North-East and national security in general. The insurgency has led to increased incidence of diseases, food insecurity, unemployment, violation of human rights, displacements and shelter problems among others. The study was designed to investigate the impact of boko haram insurgency on the nutritional status of two communities in Gulani Local Government Area, Yobe State, Nigeria. The study was a descriptive cross sectional study conducted among 391 respondents utilizing a simple random sampling technique. A questionnaire was administered to obtain information from respondents while anthropometric measurements of height and weight were carried out with the appropriate instruments. The analysed data was presented in descriptive of frequency, Tables and charts. Majority of the respondents were males 269(68.8%) and most 185(47.3%) were farmers. The mean height, weight and body mass index (BMI) were 1.61±0.87, 62.60±14.93 and 22.39±4.70 respectively. The BMI classification shows that 50.5% of the respondents had normal weight, 25.4% had overweight and 19.2% were underweight. Similarly, majority of the respondents 227(70.8%) affirmed that the insurgency has affected the availability and quantity of staple foods, affected their ability of going to farms 169(61.0%) and led to increase in food prices 305(78.0%). Meanwhile, 142(36.3%) affirmed that they harvest 10-20 quantity (bags) of grains before the insurgency, which slightly decreased to 5-10 quantity (bags) of grains as affirmed by 135 (34.5%) of the respondents during the insurgency. The study shows the boko haram insurgency continues to pose serious challenges to farming activities, which has led to increased food prices as well as poor nutritional status of residents of the affected areas. Hence adequate measures must be put in place to mitigate the impact of the insurgency on residents of the affected areas.
“It makes me work strong”: Cannabis and cannabis use persistency in a Nigerian city
Authors: Ugwu Ugochukwu T.
Published: June 2022

Cannabis use has been researched comprehensively, especially in the western societies. In Africa, there is also a corpus of literature on cannabis use. In Nigeria, particularly in Awka, southeast Nigeria, there is a dearth of qualitative empirical research on cannabis use among different classes of people. This study sets out to understand cannabis use motive in Awka and why cannabis users persist in using cannabis. In-depth interview (IDI) was conducted among 18 participants selected through snow balling. The interviews were conducted between November 2018 and June 2019. Data collected were transcribed and analyzed and two major themes of coping and enhancement were generated. Data showed non-medical use of the drug by the participants. Findings suggest among others that cannabis use has continued because it helps users to cope with life challenges. Also, cannabis is seen as a boost to strength among users, especially those who do jobs that demand sustained physical energy, among others, and enhancement functions users derive from it. Consequently, there is the need for practical policy to tame recreational cannabis use in this Nigerian City.
Optimal sizing and placement of shunt capacitors on the distribution system using Whale Optimization Algorithm
Authors: Okelola M. O. , Adebiyi O. W. , Salimon S. A. , Ayanlade S. O. , Amoo A. L.
Published: June 2022

This paper aims at power loss minimization and reduction of cost due to losses in the distribution network as well as improvement of the network voltage stability and profile via optimal shunt capacitor allocation. The optimal shunt capacitor allocation was obtained using Whale Optimization Algorithm considering technical (real power loss and VSI) and economic objective functions as sub-optimal allocation may result in undesired effects on the network. The obtained optimal sizes of the shunt capacitors were placed on the obtained location of the distribution networks to ascertain the behavior of the networks before and after their placements taking power loss, cost due to losses, and voltage stability index as the performance metrics. A comparison of these performance metrics under four cases, namely base case (case one), installation of one SC (case two), installation of two SCs (case three), and installation of three SCs (case four) were demonstrated using standard IEEE 33-bus and Dada 46-bus distribution networks. The results gave a percentage loss reduction of 33.74% with 27.60% annual net saving for the IEEE 33-bus network and 22.24% loss reduction with 25.60% annual net saving for the Dada 46-bus network. Hence, reduction in the total power losses and costs. Also, the voltage profile and voltage stability index were significantly improved.
Production of natural gas and liquefied petroleum gas from flare gas using methanol based process
Authors: Ndunagu P. U. , Joel O.F. , Akuma O. , Alaike E. E.
Published: June 2022

Flare gas utilization has been a topic of discussion among stakeholders of the Nigerian Petroleum Industry and one of the simplest technical and commercial strategies is to send these gases to an existing gas pipeline with spare capacity. Peculiarities of flare gas can pose different challenges but the feasibility of the project depends on exogenous factors such as proximity to gas pipeline and availability of markets. In this work, an energy integrated methanol-based gas processing method for treatment and recovery of Liquefied Petroleum Gas (LPG) is presented using a high flaring intensity Nigerian Marginal oilfield close to an existing gas pipeline. A capacity of 60 MMscfd was determined using the flaring profile of the oilfield and a propane refrigeration system was selected as the cold process. ASPEN HYSYS V9 Cubic Plus Association (CPA) equation of state was used to optimally predict methanol (used as a hydrate inhibitor) partitioning in the methanol-hydrocarbon system. This process produced 57.15 MMscfd of natural gas, 163.7 tonne/day of LPG, and 33.19 tonne/day of stabilized condensate in line with Nigerian gas transport code specifications. The equipment count in comparison to other gas processing schemes, operational flexibility, and ease of scalability indicates that it is an economic technology that will be well suited for solving the gas flare scenario in the Niger Delta region by converting these wasted gas into more useful products.
Effect of berbamine hydrochloride on the absorption of berberine hydrochloride in an in situ single-pass intestinal perfusion system in rats
Authors: Tang Xi , Feng Hui , Gao Jie , Bi Ruohong , Pan Lin , Shi Yi , Han Yunfeng , Lai Xianrong
Published: June 2022

Purpose: To investigate the intestinal absorption characteristics of berberine hydrochloride (BBH) under different perfusion conditions in rats.Methods: Based on the in situ single-pass intestinal perfusion model of rats, HPLC was used to determine the content of berberine hydrochloride in solution after perfusion under different conditions. The absorption rate constant (Ka), effective permeability coefficient (Papp) and cumulative absorption per unit area (Q) under different perfusion conditions were analyzed by one-way ANOVA.Results: The Papp and Ka of BBH in perfusion solution at pH 7.4 were greater than those in perfusion solution at pH 6 and 8. There was no significant difference (p > 0.05) in Papp and Ka of duodenum, jejunum and ileum at high, medium and low concentrations of berberine hydrochloride perfusion solution. The Q increased linearly with increase of mass concentration of perfusion solution. The Ka and Papp of BBH in duodenum, jejunum, and ileum of BBH and berbamine hydrochloride (BAH) combined at different ratios were higher than those of BBH control group at the same BBH concentration, but absorption of BBH in the ratio B40:A50 and B30:A20 groups was highest. In the ratio of B40:A50 ratio, B30:A20 ratio group or the same concentration's BBH group, Ka and Papp of BBH decreased in the order of jejunum > duodenum > ileum.Conclusion: Berberine hydrochloride is absorbed in neutral environment of pH 7.4. The intestinal absorption mechanism of BBH is passive diffusion, and jejunum is the best intestinal segment for absorption. BAH promotes the absorption of BBH.
Effects of herbal-based toothpastes on cell viability
Authors: Kahvecioğlu Firdevs , Ülker Hayriye Esra
Published: June 2022

Purpose: To evaluate the effects of herbal-based toothpastes with different contents on the viability of L929 cells.Methods: Herbal-based toothpastes {Aloe vera - propolis herbal toothpaste, Group 1; Parodontax, Group 2; Toothpaste with miswak, propolis and tea tree extract, Group 3, Dent natural protective toothpaste with clay, Group 4; Gano fresh, Group 5} were diluted (1:1, 1:2, 1:4, 1:8, 1:16, and 1:32) in Dulbecco’s modified Eagle’s medium. L929 fibroblast cells were treated with the medium containing the herbal toothpastes for 2 min. Cell viability was assessed using methyl tetrazolium test. The viability of the negative control group was set at 100 %, and the percentage viability of all groups was determined accordingly.Results: Cell viability was significantly reduced at all dilutions in Group 5 (p = 0.00). This trend was also observed in Group 4. All dilutions except 1:32 significantly affected cell viability (p = 0.00). In Group 2, only the 1:1 dilution showed a toxic effect (p = 0.00). The samples in Groups 1 and 3 did not show statistically significant cytotoxicity to L929 cells (p > 0.05).Conclusion: Herbal toothpastes containing substances such as sodium lauryl sulfate (Group 5) and sodium benzoate (Groups 2 and 4) are cytotoxic towards L929 cells. Groups 1 and 3 did not contain detergents but contain potassium sorbate as a preservative; hence, they are not toxic.
Cardiovascular risks and primary interventions among treated rheumatoid arthritis patients: Experience from a tertiary care centre in Kuala Lumpur, Malaysia
Authors: Radhakrishnan Shantini , Razak Salmi Abdul , Said Mohd Shahrir Bin Mohamed , Shah Noraida Mohamed , Redzuan Adyani Md
Published: June 2022

Purpose: To investigate the cardiovascular risk among treated rheumatoid arthritis (RA) patients to predict the factors associated with high cardiovascular risk and to determine the presence of pharmacotherapy primary prevention among treated RA patients with high cardiovascular disease (CVD) risk.Methods: The study was a prospective cross-sectional study on adult patients diagnosed and treated for RA and without established heart disease/stroke. Cardiovascular risk scoring was based on Framingham Cardiovascular Disease 10-year risk prediction model (BMI model) x 1.5 factor while descriptive and inferential analyses were done using SPSS.Results: High CVD risk was defined as FRS-CVD cardiovascular risk categories (>20%) and 55.9% of patients were at high CVD risk. Use of Hydroxychloroquine (OR: 0.44; 95 % CI: 0.21- 0.92; p= 0.028) and COX-2 inhibitors (OR: 0.31; 95% CI:0.10- 0.95; p = 0.039) were found to be significantly associated with high CVD risk among treated RA patients. Significant number of high CVD risk patients did receive pharmacotherapy primary prevention (p = 0.001).Conclusion: Hydroxychloroquine and COX-2 inhibitors are independent negative risk predictors associated with high CVD risk among treated RA patients. Baseline cardiovascular risk data may be useful in rational use of medications to treat RA, considering that cardiovascular related mortality is the leading cause of death in RA.
Effect of regional versus general anaesthesia on postoperative opioid consumption, clinical outcomes and cognitive function in Chinese patients undergoing metastatic cancer surgery
Authors: Xu Chunmei , Wang Fang , Liu Jiaojiao , Zhan Weiwei , Gao Changjian
Published: June 2022

Purpose: To compare postoperative opioid consumption, inflammatory biomarkers, cognitive function and safety profile of regional anesthesia (RA) versus general anesthesia (GA) in Chinese patients undergoing metastatic cancer surgery.Method: Chinese patients undergoing metastatic cancer surgery were enrolled and received either RA or GA) in allocation ratio of 1:1. The following efficacy variables were assessed: 1) pain score was measured on VAS scale; 2) post-operative consumption; 3) inflammatory biomarkers; 4) cognitive function; 5) clinical outcomes. Safety was also assessed.Results: Data for a total of 220 patients were analyzed. Compared to GA alone, the combination of RA and GA demonstrated significantly greater reduction in post-operative pain with decreased postoperative opioid consumption. Also, RA/GA combination inhibited inflammatory response when compared to patients who received GA only, indicating that RA + GA improved immune response in patient undergoing surgical intervention. The severity of signs and symptoms of dementia were similar at baseline visit (p > 0.05). Patients of RA/GA group had significantly greater relief in signs and symptoms of dementia/cognitive impairment, when compared to the GA-treated patients (p < 0.05). However, incidence of complications (including adverse events) was comparable for both groups (p > 0.05). Additionally, RA/GA was also associated with shorter length of hospital stay, compared to GA.Conclusion: RA/GA combination demonstrates significantly greater improvement in the level of clinical outcomes, decreases postoperative opioid consumption, and improves cognitive functions when compared to GA in Chinese patients undergoing metastatic cancer surgery.
Expression of mTOR conduction pathway in human osteosarcoma MG-63 cells and their stem cells, and the inhibitory effect of different doses of rapamycin
Authors: Wu Hao , Wang Xuelei , Cao Zhilin , Zheng Mingdi , Zhao Zhongyuan , Zhao Yuchi , Zhang Jianzhong , Zhang Jianzhong , Cheng Gong
Published: June 2022

Purpose: To investigate the expressions of rapamycin target protein (mTOR) conduction pathway in human osteosarcoma MG-63 cells and their stem cells, and to examine the inhibitory effect of different doses of rapamycin.Methods: mTOR mRNA in osteosarcoma stem-like cells and human osteosarcoma MG-63 cells were determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR). The cells were treated with different doses of rapamycin and divided into low dose group (0.5 mg), medium dose group (1.0 mg), high dose group (2.0 mg) and blank (control) group. Apoptosis and cell cycle of MG-63 cells were determined by flow cytometry, while proliferation of MG-63 cells up was assessed by CCK-8 kit.Results: mTOR in human osteosarcoma MG-63 cells was significantly lower than that in osteosarcoma stem-like cells. Compared with the control group, mRNA expression levels of mTOR in MG-63 cells and osteosarcoma stem-like cells were significantly decreased after treatment with different concentrations of rapamycin (p < 0.05). MG-63 cells treated with various doses of rapamycin exhibited a significant decrease in their proliferation, compared with control group, while only the high rapamycin concentration group exhibited a significant decrease in osteosarcoma stem-like cell proliferation (p < 0.05). Treatment with rapamycin in MG-63 cells and osteosarcoma stem-like cells resulted in a significant increase in apoptosis, prolonged G0/G1 phase and shortened S phase (p < 0.05).Conclusion: Rapamycin inhibits the expression of mTOR mRNA in osteosarcoma stem-like and MG-63 cells. It also inhibits the proliferation and cell cycle formation of osteosarcoma stem-like cells and MG-63 cells via mTOR signal pathway. These findings may provide a new target for the treatment of osteosarcoma.
Elektronički zdravstveni zapis
Authors: Balenović Antonija , Lazić Vanja , Mesarić Jasna
Published: June 2022

Digitalne tehnologije i elektronički zdravstveni zapis (e‑Karton) imaju mogućnost smanjiti vrijeme koje liječnici troše na izradu zdravstvene dokumentacije, što osigurava više vremena za izravnu i kvalitetniju zdravstvenu skrb o pacijentima. Racionalizacijom poslova oko vođenja zdravstvene dokumentacije smanjuje se vrijeme administrativnih obveza te poboljšava efikasnost i zadovoljstvo zdravstvenih radnika. Osim prednosti, utvrđene su i poteškoće i prepreke u implementaciji e‑Kartona: ulazni troškovi, digitalna nepismenost, vrijeme potrebno za edukaciju, problem nepotpunih ili loših digitalnih aplikacija, jezične varijacije i terminološka neusklađenost, medicinsko-pravna usklađenost i interoperabilnost s postojećim računalnim sustavima. Iako nova tehnologija elektronskog vođenja zdravstvenih podataka ima brojne prednosti kako za pacijente, tako i za liječnike i za cjelokupni zdravstveni sustav, prepreke koje postoje moraju se identificirati i riješiti kako bi se osigurala sigurna i učinkovita integracija i provođenje zdravstvene skrbi. Promicanje ovih tema važno je kako bi se kvantitativno i kvalitativno obuhvatili te analizirali svi različiti učinci nastali nakon implementacije e‑Kartona budući da izravno utječu na sigurnost i kvalitetu zdravstvene skrbi.
Aplikasi Kaedah Usul Fiqh dalam Memahami Hadith-Hadith Berkaitan Wabak dan Penetapan Langkah Keselamatan
Authors: Aris Helimy , Abdul Halim Amran , Muslim Nazri
Published: June 2022

Artikel ini membahaskan tentang aplikasi beberapa Kaedah Usul Fiqh dalam memahami hadith-hadith wabak dan sejauh mana ia sesuai dijadikan sebagai asas dalam penetapan hukum dan prosidur keselamatan dalam usaha memutuskan rantaian sesuatu wabak melalui kaedah analisis teks. Hadith wabak adalah salah satu daripada teks nabawi yang perlu difahami melalui kerangka ilmu usul fiqh agar prinsip-prinsip Islam yang tersirat di sebaliknya dapat dihayati oleh masyarakat. Para sarjana Islam dilihat telah memainkan peranan dalam mengeluarkan ‘illah yang boleh dijadikan sandaran hukum ke atas situasi semasa yang perlu kepada pandangan dan penyelesaian Islam. Selain kaedah istinbatiyyah, kaedah istidlaliyyah seperti maslahah mursalah yang menjadi sebahagian perbahasan ilmu Usul Fiqh juga dilihat amat signifikan dalam menentukan keharusan atau sebaliknya tindakan pihak berwajib dalam membendung penularan penyakit berjangkit.
The Influence of Marketing Strategy and Lifestyle on the Purchase Decision of Mitsubishi Xpander at PT. Dipo Internasional Pahala Otomotif
Authors: Sri Rezeki  , Ihdina Gustina
Published: June 2022

This study aims to determine the effect of Marketing Strategies and Lifestyle on Purchasing Decisions at PT. Dipo Internasional Pahala Otomotif. The population in this study are all consumers who have made purchases at PT. Dipo Internasional Pahala Otomotif in 2019. By using the Slovin formula with an error rate of 10%, a total sample of 91 respondents was obtained. The research analysis shows that the Marketing Strategy and Lifestyle partially and simultaneously positively and significantly affect Purchasing Decisions at PT. Dipo Internasional Pahala Otomotif. The results of this study are supported by the value of R square (R2) which means that the Marketing Strategies and Lifestyle have an effect on the Purchasing Division at PT. Dipo Internasional Pahala Otomotif. While the remaining is affected by other factors originating from outside this research model such as price discounts, advertising, consumer attitudes, consumer confidence, and brand image.
Analysis of Efforts to Increase Customer Loyalty in Improving Brand Trust, Marketing Communication Strategies and Product Diversity
Authors: Dedy Lazuardi
Published: June 2022

This study aims to determine the effect of Brand Trust, Marketing Communication Strategies and Product Diversity on Customer Loyalty at PT. Jaya Abadi Chandra Kartika Medan. The population in this study are customers of PT. Jaya Abadi Chandra Kartika Medan totaling 137 respondents. The technique of determining the number of samples used in this study is Slovin formula and totaling 102 respondents. The results of the research analysis show that Brand Trust, Marketing Communication Strategies and Product Diversity partially have a positive and significant effect on Customer Loyalty at PT. Jaya Abadi Chandra Kartika Medan. The results showed that Brand Trust, Marketing Communication Strategies and Product Diversity simultaneously have a positive and significant effect on Customer Loyalty at PT. Jaya Abadi Chandra Kartika Medan. The results of this study are supported by the value of R square (R2) which means Brand Trust, Marketing Communication Strategies and Product Diversity have an effect on Customer Loyalty at PT. Jaya Abadi Chandra Kartika Medan. While the remaining is effected by other factors originating from outside this research model such as brand image, promotion, and location.
The Impact of Infrastructure Development and the Role of Community Leaders on the Number of Visits and the Image of Spinsur Tourism in the Lake Toba Region, North Sumatra with the Partial Least Square Method
Authors: Riko Fridolend Sianturi  , Lasma Ria Tampubolon  , Ferdinand Napitupulu
Published: June 2022

This study aims to analyze and examine the Impact of Infrastructure Development and the Role of Community Leaders on the Number of Visits and the Image of Spinsur Tourism in the Lake Toba region, North Sumatra. The research location was taken at Sipinsur Tourism Object, which is located in Paranginan District, Humbang Hasundutan Regency. The sample size used is 100 people. The sampling technique used is simple random sampling. The research was conducted from 2019 to 2020. There are two data collected, namely primary data in the form of questionnaires and secondary data obtained through books, literature and other sources. The research method uses Partial Least Square (PLS). The results showed that infrastructure development had no positive and insignificant effect on the number of visits, the role of community leaders had a positive and significant effect on the number of visits, and infrastructure development had no positive and insignificant effect on tourism image. The role of community leaders had a positive and significant effect on tourism image. The community has a positive and significant effect on the image of tourism, the role of community leaders has a positive and significant effect on the image of tourism, infrastructure development has no positive and insignificant effect on the image of tourism through the number of visits and the role of community leaders has a positive and significant effect on the image of tourism through the number of visits.
Analysis Of The Effect Of Marketing Mix On The Competitive Advantage Of Samoto Products In PT. Utama Netindo Semesta
Authors: Ihdina Gustina  , Dedy Lazuardy  , Sienny
Published: June 2022

This study aims to determine the effect of Product and Price on the Competitive Advantage of Samoto's Products at PT. Main Netindo Semesta. The research population that will be used in the study are all consumers who made purchases on Samoto stabilizer products during the 2020 period as many as 2,905 consumers. The sample that will be used in this research is 97 consumers. The results of the research analysis show that Product and Price simultaneously have a significant influence on Competitive Advantage at PT. Main Netindo Semesta. For the coefficient of determination, it is found that Product and Price can explain its relationship with Competitive Advantage at PT. Main Netindo Semesta.
Training preschool educational institutions on the performance of uzbek folk instruments
Authors: Mukhammadiev Muslimbek
Published: June 2022

This article provides detailed information on the use of methods by educators in preschool education to engage children in Uzbek folk instruments, the study of various songs through the words of the instrument, the use of music in determining the temperament of children given.
Inexpensive Ways to Improve Homebuilders Tree Survival
Authors: Anderson L.M. , Barrows-Broaddus Jane
Published: June 2022

Observations of trees around recently built single- and multiple-family dwellings in two expanding Georgia cities showed that more than 85% of hardwoods and 95% of pines survived construction, but more than half showed signs of stress. The results suggest guidelines for builders who want to promote the survival and health of trees following home construction on wooded lots.
Structural Dynamics and Susceptibility of Anti-Alzheimer’s Drugs Donepezil and Galantamine against Human Acetylcholinesterase
Authors: Nutho Bodee , Yanarojana Somchai , Supavilai Porntip
Published: June 2022

Alzheimer’s disease (AD) is a major public health problem worldwide due to an increase in the elderly population. The current pharmacotherapy for the early stages of AD is mainly dependent on cholinesterase inhibitors. Two of the most commonly used anti-AD drugs, donepezil (DPZ) and galantamine (GLM), are selective inhibitors for human acetylcholinesterase (hAChE). However, the inhibitory activity of DPZ on hAChE was more potent than GLM by ~85 times. To better understand the molecular basis for differences in mode of inhibition of hAChE by both drugs, molecular dynamics (MD) simulation was performed. The results showed that the active site residues of hAChE/DPZ had the higher hydrogen bond occupancies as compared to hAChE/GLM. Nevertheless, the 2 drugs directly formed hydrogen bonds with the catalytic residue H447 of hAChE. The per-residue free energy decomposition suggested that DPZ interacted with the residues in peripheral anionic site of hAChE, resulting in the greater binding affinity of DPZ than that of GLM toward hAChE. The binding free energy calculation based on MM-PBSA and MM-GBSA methods indicated that van der Waal interactions played a predominant role as the driving force for binding process of DPZ and GLM to hAChE. Moreover, the predicted total binding free energy of hAChE/DPZ was stronger than hAChE/GLM, which was consistent well with the experimental data. We hope that our findings provide useful information for further design of novel hAChE inhibitors.

HIGHLIGHTS

Anti-Alzheimer’s drugs donepezil and galantamine in complex with human acetylcholinesterase were explored by MD simulations and binding free energy calculations

The MM-PB(GB)SA-based binding free energy indicated that donepezil exhibited a more favorable binding affinity to human acetylcholinesterase than galantamine

The molecular rotation of galantamine during MD simulation resulted in the reduction of hydrogen bond occupancies with D74 and S203

The van der Waals interactions were considered as the major contributor to the binding of both drugs

GRAPHICAL ABSTRACT
Procrastination and anxiety: Exploring the contributions of multiple anxiety-related disorders
Authors: Hutchison Taylor E. , Penney Alexander Murley , Crompton Jessica E.
Published: June 2022

Background

Procrastination is the unnecessary delay of a task that subsequently creates anxiety (Rothblum, Solomon, & Maurakami, 1986). Research suggests that procrastination is linked with poorer mental health, but questions remain regarding its association with anxiety disorders. Studies exploring obsessive-compulsive disorder (OCD) and procrastination have found high levels of procrastination in OCD (Ferrari & McCown, 1994), but have also found no association between obsessive thoughts and procrastination (Kağan, Çakır, İlhan, & Kandemir, 2010). Scher and Osterman (2002) found that procrastination correlated with physiological anxiety and social anxiety, but not worry. No previous research has examined the connection between procrastination and health anxiety.

Participants and procedure

A non-clinical university sample (N = 300) completed online self-report questionnaires in order to examine the relationships between procrastination and symptoms of OCD, generalised anxiety disorder, social anxiety disorder, health anxiety, and panic disorder.

Results

Symptoms of panic disorder, social anxiety disorder, and health anxiety correlated with levels of procrastination. However, using a multiple regression analysis, only panic disorder symptoms uniquely predicted procrastination.

Conclusions

It is proposed that people with panic disorder may procrastinate to avoid anxiety inducing situations, or that individuals who frequently procrastinate may become sensitive to the anxiety caused by procrastination, thereby potentially triggering panic disorder. The full implications of these findings are further discussed.
Peran Motivasi Intrinsik Dalam Memediasi Etika Kerja Islam, Religiusitas Dan Kepuasan Kerja Terhadap Komitmen Organisasi
Authors: Nazah Khairatun , Nafil Herwan
Published: June 2022

Tujuan dalam penelitian ini yaitu untuk mengetahui peran motivasi intrinsik dalam memediasi etika kerja isalam, religiusitas dan kepuasan kerja terhadap komitmen organisasi. Populasi dan sampel dalam penelitian ini yaitu seluruh dosen tetap kampus Politeknik Unggul LP3M yang berjumlah 65 Dosen baik yang beragama muslim. Dimana teknik penarikan sampel menggunakan total sampling. Hasil penelitian 1) motivasi intrinsik tidak memiliki peran dalam memediasi etika kerja islam terhadap komitmen organisasi, 2) motivasi intrinsik tidak memiliki peran dalam memediasi religiusotas terhadap komitmen organisasi, 3) motivasi intrinsik tidak memiliki peran dalam memediasi kepuasan kerja terhadap komitmen organisasi.
Quí-passatempo: uma revista educativa sobre o laboratório de química
Authors: Aragão Adriano Lobão , Davi Adrielle de Oliveira , Pereira Conceição de Maria dos Santos , Cole Thiciana Silva Sousa
Published: June 2022

A revista Quí-passatempo foi desenvolvida com o objetivo de facilitar a aprendizagem sobre o laboratório de química aos alunos através de um conteúdo lúdico, leve, educativo e divertido. Com isso, ela trás uma abordagem totalmente ilustrativa e dinâmica com várias informações importantes e atividades que possibilitam o aluno aplicar seu próprio conhecimento adquirido na revista para resolvê-las. Ao longo do estudo, o aluno será convidado a observar, refletir, relacionar diferentes conhecimentos, formular hipóteses e também solucionar problemas.
Dietary diversity and associated factors among pregnant women in urban Northern Ghana
Authors: Atosona Ambrose
Published: June 2022

Background: Though low dietary diversity during pregnancy results in low nutrient intake and adverse pregnancy outcomes, information on dietary diversity and its associated factors among pregnant women in Ghana particularly Northern Ghana is scanty. This study therefore assessed dietary diversity and associated socio-demographic characteristics among pregnant women in urban Northern Ghana. Methods: An analytical cross-sectional study design was used, involving 273 pregnant women randomly selected from 8 health facilities in Tamale Metropolis and Sagnarigu Municipality. Socio-demographic characteristics of participants were documented using a structured questionnaire. Dietary diversity of participants was assessed using a 24 hour dietary recall method and the dietary diversity score was calculated based on ten food groups. Chi-square test and binary logistic regression analysis were used to identify the factors associated with low dietary diversity. Results: The mean age of the participants was 26.44 ±5.75 years with minimum and maximum ages of 16 and 44 years respectively. About 48% of the women had low dietary diversity. The mean dietary diversity score was 4.87 ± 2.04. Having no education at all [Odds Ratio (OR) = 5.5; 95% CI (2.09 –14.31); p = 0.001] and having only primary education [OR = 3.8; 95% CI (1.21 –12.09); p < 0.022] were significantly associated with low dietary diversity. Conclusion: The study revealed that the prevalence of low dietary diversity is high among pregnant women in urban Northern Ghana. Improving the educational level of women is recommended to improve their dietary diversity.
Modulating effects of Fumonisin B1 and Ochratoxin A on immune cells in human carcinoma
Authors:   , Adam Jamila Khatoon
Published: June 2022

Fumonisin B1 (FB1) and ochratoxin A (OTA) represent examples of mycotoxins of greatest public health and agro-economic significance. They ex¬ert adverse effects on humans, animals and crops that result in illnesses and economic losses. Fumonisin B1 are cancer-promoting metabo¬lites of Fusarium proliferatum and F verticillioides, (formerly moniliforme), and are implicated in oesophageal cancer. Ochratoxins are metabolites of both Aspergillus and Penicillium species. These compounds are known for their nephrotoxic effects in all animal species and may promote tumours in humans. In man OTA exhibits unusual toxicokinetics, with a half-life in blood of 840 h (35 days) after oral ingestion. Although much is known regarding the toxicology of these toxins, little is known of the effects of these toxins on the immune system. The aim of this study was to determine and compare the immunomodulating effects of FB1 and OTA in human carcinoma. Initial experiments involved isolating lymphocytes and neutrophils from healthy volunteers. The isolated cells were exposed to either FB1 or OTA on a dose and time dependent level and LD50 of the toxins was determined. Thereafter, challenge tests were performed, whereby lymphocytes and neutrophils isolated from volunteers, oesophageal cancer patients and breast cancer patients were exposed to the LD50 dose of either FB1 or OTA for the appropriate time. The effect of the toxins was demonstrated by viability studies, light microscopy and electron microscopy. Cytokine receptors (CK, TNF and CSF) were evaluated by immuno-cytochemical methods and the levels of circulating cytokines (IL –1, IL-6, IL-8, IL-10 and TNF-) were determined using ELISA kits.
Çalgı Çalma Sürecini Etkileyen Faktörlerin İncelenmesi
Authors: ŞEKER Sadullah Serkan
Published: June 2022

Araştırmanın amacı müzik öğretmeni adaylarının çalgı performans öz-yeterlik, çalgı çalışma sürecinde öz-düzenleme ve çalgı çalışma sürecine erteleme düzeyleri arasındaki ilişki incelenmiştir. Araştırmaya 454 aday katılmıştır. Araştırmadan elde edilen sonuçlara göre adayların çalgı performans öz-yeterlik ve çalgı çalışma sürecinde öz-düzenlemeli öğrenme düzeyleri yüksek, çalgı çalışma sürecinde erteleme düzeyleri ise düşük olarak bulunmuştur. Araştırmada adayların çalgı çalışma sürecindeki erteleme düzeylerinin çalgı çalışma sürecinde öz-düzenlemeli öğrenme ve çalgı performans öz-yeterlik değişkenleri tarafından ne derecede açıklandığının belirlenmesi için hiyerarşik regresyon analizi yapılmış, çalgı çalışma sürecinde öz-düzenlemeli öğrenmenin ertelemenin çalgı performans öz-yeterliğe göre negatif yönde daha güçlü bir açıklayıcısı olduğu görülmüştür. Analizde adayların çalgılarını kendi isteklerine göre seçip seçmediğine göre regresyon analizi tekrarlandığında ise çalgı performans öz-yeterliğin çalgısını isteyerek seçmeyen grupta etkisini tamamen yitirdiği saptanmıştır. Analizde adayların çalgılarını isteyerek seçip seçmemelerinin tüm değişkenlerde istatistiksel olarak anlamlı fark oluşturduğu gözlemlenmiş, farkın her değişkende de çalgısı isteyerek seçen grubun lehine olduğu tespit edilmiştir. Cinsiyet açısından araştırma değişkenleri incelendiğinde ise sadece çalgı çalışma sürecinde öz-düzenlemede kadınlar lehine anlamlı farka rastlanmıştır. Adayların mezun oldukları lise türüne göre araştırma değişkenlerinde anlamlı farka rastlanmamıştır. Araştırma değişkenleri arasında yapılan korelasyon analizi sonucunda ise çalgı performans öz-yeterlik ile çalgı çalışma sürecinde öz-düzenlemeli öğrenme arasında yüksek düzeyde pozitif ilişki, çalgı çalışma sürecinde erteleme ile çalgı performans öz-yeterlik ve çalgı çalışma sürecinde öz-düzenlemeli öğrenme arasında negatif yönde orta düzey ilişki olduğu tespit edilmiştir.
Üniversite Sınavına Hazırlanan Ortaöğretim Öğrencilerinin Dijital Eğitime Yönelik Görüşleri
Authors: ŞERBETÇİ Havva Nur , BÜYÜKŞAHİN Yasemin
Published: June 2022

Bu çalışma koronavirüse karşı eğitim alanında alınan tedbirler sonucunda dijital eğitime geçilmesine ilişkin süreç hakkında üniversite sınavına hazırlanan 12. sınıf öğrencilerinin görüşlerinin değerlendirilmesi için yapılmıştır. Araştırmanın çalışma grubunu 4 kadın, 3 erkek olmak üzere üniversite sınavına hazırlanan lise son sınıf öğrencisi oluşturmaktadır. Var olan bir durumun etkilerinin derinlemesine incelenmesi için nitel çalışma yöntemlerinden durum çalışması ile araştırma yürütülmüştür. Veri toplama aracı olarak yarı yapılandırılmış görüşme formu kullanılmıştır. Toplanan verilerin analizinde içerik analizinden faydalanılmıştır. Çalışmanın sonucunda dijital eğitim platformları yani EBA ile TRT EBA TV aracılığıyla gerçekleştirilen uzaktan eğitimin verimsiz ve yetersiz olduğunu belirlenmiştir. Ayrıca Covid-19 pandemisinin eğitimi olumsuz yönde etkilemesinin yanı sıra sınava hazırlık sürecinde sınavın ertelenmesi ile öğrencilere eksiklerini tamamlamaları için fırsat oluştuğu tespit edilmiştir.
Ayurvedic Approach for Management of Ulcerative Colitis- A Case Report
Authors: Gautam Sankar , Praveen Kumar B,Harshitha K.S., Narayan Pandey Rashmi Mutha, Ajay Kumar Sahu, Sunita Rawat
Published: June 2022

Introduction: Ulcerative colitis (UC) is related to chronic mucosal inflammation and manifestations such as bloody diarrhea and abdominal cramps, tenesmus and urgency. Main Clinical Finding: A 63-year-old male patient, known case of ulcerative colitis under regular allopathic treatment for 16 years had recurrent symptoms of blood and mucous mixed stool (2-3 times/day) with abdominal tenesmus and urgency to defecate. Diagnosis: Based on the clinical features like tenesmus, increased frequency of blood mixed mucoid defecation, and decreased volume of faeces, this case of UC was diagnosed as Raktaja Pravahika. Interventions and Outcome: The combinations of medicines based on Ayurvedic principles were intervened. Significant result was observed in signs and symptoms with Grade I UC impression within 15 months without recurrence of any signs symptoms for about 6 months. Conclusions: This treatment was found effective for this case. It could be a valuable intellectual addition to researchers and to the medical field.
PENGARUH PENGGUNAAN MEDIA PEMBELAJARAN APLIKASI DISCORD TERHADAP HASIL BELAJAR SISWA PADA MATA PELAJARAN PENDIDIKAN AGAMA ISLAM DI SMP MUHAMMADIYAH 12 BINJAI
Authors: Puspita Dewi Kiki
Published: June 2022

The problem that arises is the lack of learning media in the learning process, especially in this day and age, learning media have developed very widely. Especially during the pandemic, the school only used the WhatsApp application, and it didn't work well, and it would affect the learning outcomes of students. Therefore, of course, from the pandemic period that transformed into the new normal period, their learning outcomes will also experience changes. To view t Table dk= + - 2 = 17+17-2 = 32, 349, with the obtained t table at = 0.05 (5%) 2-party test obtained t table = 0.339 It turns out that th > tt then Ha is accepted. So, there is a difference in learning outcomes between the use of discord media, namely the class that uses the application and the control class, namely the conventional class on student learning outcomes of PAI subjects at SMP Muhammadiyah 12 Binjai. It can be seen from the average value between the control class (54.00) and the experimental class (81.00). The effect of using the discord application is proven by the mean whienoy u test, the mean rank of the experimental class is 17.38 and the mean value of the control class is 6.14. this means that the use of the Discord Application is appropriate for online learning.