bluuebunny/crossref_metadata_2025 huggingface dataset:
Myo-inositol supplementation in women of reproductive age with subclinical hypothyroidism and obesity on the background of vitamin D deficiency
Authors: Pasyechko N.V. , Kulchinska V.M. , Kadubets S.V.
Published: October 2021

Background. In recent years, thyroid diseases occupy the top places in the structure of the endocrine pathology. There exists a tight functional relationship between the thyroid and reproductive systems, which leads to a high probability of the development of combined disorders in one of these links of homeostasis. The problem of reproductive health disorders is of particular concern around the world and is relevant to the study of the impact of thyroid diseases on both fertility and pregnancy, especially in conditions of comorbidity. The purpose of the study was to investigate the effect of myo-inositol on the reproductive function of women with subclinical hypothyroidism on the background of autoimmune thyroiditis and obesity. Materials and methods. The study included 98 patients aged 18–40 years with subclinical hypothyroidism, overweight, or obesity on the background of autoimmune thyroiditis. They were randomly subdivided into two groups. Patients of the first group (n = 49) before the basic treatment received myo-inositol at a dose of 2000 mg/day and cholecalciferol at a dose of 2000 IU/day. Patients of the second group (n = 49) before the basic treatment received only cholecalciferol at a dose of 2000 IU/day. Results. Vitamin D deficiency was observed in 90.81 % of women with subclinical hypothyroidism, and vitamin D insufficiency in 9.19 %. A negative correlation was found between the level of 25(OH)D and the level of TPO-Ab (r =–0.189; p < 0.05). There was a weak negative correlation between the level of 25(OH)D and the level of the HOMA-IR (r = –0.168; p < 0.05). The administration of myo-inositol together with vitamin D led to a significant increase in the content of 25(OH)D, as well as to a decrease in the titer of TPO-Ab. Conclusions. The positive effect of myo-inositol drugs together with vitamin D on the functional state of the thyroid gland, on the level of TPO-Ab and HOMA-IR in women of reproductive age with subclinical hypothyroidism and obesity has been established.
Immunological aspects of bacterial keratites in patients with diabetes mellitus
Authors: Zavoloka O.V. , Bezditko P.A. , Abramova L.P. , Vekshyn V.O.
Published: October 2021

Background. The purpose was to analyze the cytokine balance of lacrimal fluid in patients with bacterial keratitis and diabetes mellitus (DM) at the first visit and to identify the immunological aspects of the disease. Materials and methods. The analysis of pro- and anti-inflammatory cytokine concentration in the lacrimal fluid was performed in 17 patients with type 1 DM and bacterial keratitis and 15 nondiabetic patients with bacterial keratitis at the first visit. Data from 14 healthy individuals were used for comparison. In addition to standard ones, ophthalmic examination methods included bacteriological examination, fluorescein test, anterior segment optical coherence tomography, non-contact corneal aesthesiometry. The levels of interleukin (IL) 1β, IL-6 and IL-10 in the lacrimal fluid of the sick and the contralateral eye were determined by a quantitative colorimetric enzyme-linked immunosorbent assay using ELISA kits. Results. In DM patients with bacterial keratitis, the concentration of IL-1β and IL-6 in the lacrimal fluid of the sick eye exceeded that in healthy individuals (p < 0.05) and did not differ significantly from nondiabetic patients with bacterial keratitis (p > 0.05). In the lacrimal fluid of the contralateral eye of DM patients with bacterial keratitis, the level of IL-1β and IL-6 exceeded the corresponding indicators of nondiabetic patients with bacterial keratitis and healthy individuals (p < 0.05). The concentration of IL-10 in the lacrimal fluid of the contralateral eye in DM patients with bacterial keratitis exceeded that in healthy individuals (p < 0.05) and did not significantly differ from those in nondiabetic patients with bacterial keratitis (p > 0.05). Conclusions. DM patients with bacterial keratitis have immunological features of the disease.
Modern approach to diagnosis and treatment of post-traumatic periorbital scarring
Authors: Petrenko O.V. , Hryhorash N.V.
Published: October 2021

Background. The treatment of cicatricial deformities of the periorbital region is one of the most difficult problems of ophthalmoplasty. The choice of treatment tactics depends on the correct assessment of the type of periorbital scarring, which further determines its effectiveness. Based on the analysis of literature sources, the causes of periorbital scarring are determined, and modern me-thods of their clinical assessment and treatment are presented. The purpose: to analyze the current state of the issues of pathogenesis, classification, diagnosis, and treatment of post-traumatic cicatricial deformities of the periorbital region. Materials and methods. The research was carried out using the search and information systems PubMed, eLibrary, Google Scholar, and library databases for the period 2012–2020. Results. It was found that the formation and type of scars depend on many internal and external factors. The most common classification divides the scars into normotrophic, atrophic, hypotrophic, which refer to superficial scars, as well as deep — hypertrophic, keloid, and mixed. Determining the stages of scar tissue formation is important for choosing a method of treating a patient and obtaining the most positive result. Various thoughts are given regar-ding the stages and timing of the wound healing and scar formation process. The main modern methods of assessing and diagnosing scars have been determined, their advantages and disadvantages have been analyzed. The modern approaches to the treatment of scars based on their type were analyzed. Conclusions. The results of the analysis of modern literary sources showed that the issue of the etiology and pathogenesis of pathological scars has not yet been finally resolved. There is no single approach to diagnosis and treatment of scars, the optimal timing of treatment initiation. A particular problem is the treatment of cicatricial deformities of the periorbital region, which is predetermined by its anatomical and functional complexity. All this makes the task of studying the features of the course of scar formation of this particular area and the development of individualized algorithms for their treatment urgent.
Experience in the use of Brirosa and Rozacom in secondary glaucoma
Authors: Konovalova N.V. , Khramenko N.I. , Guzun O.V. , Kovtun A.V.
Published: October 2021

Background. Glaucoma is one of the most acute medical and social problems that cause enormous economic damage to society. Secondary glaucoma is the result of complications of such eye diseases as inflammation of the choroid of the eye, retinal vascular thrombosis. The purpose was to determine the effect of Briroza and Rozacom on the condition of the visual analyzer in patients with secondary glaucoma. Material and methods. The study involved 58 patients (58 eyes) with a unilateral process. All patients were divided into three groups. Groups 1 and 2 consisted of the patients with se-condary glaucoma after anterior recurrent iridocyclitis — 32 patients (32 eyes) in remission and relapse, respectively. Group 3 included patients with secondary (neovascular) glaucoma, which resulted from the central vein stenosis (CVS) and its branches — 26 patients (26 eyes). Results. In the first and second groups, Briroza administration resulted in the intraocular pressure decrease by 21.6 % (p = 0.001) — 21.0 ± 3.5 mm Hg. After a course of treatment in groups 1 and 2, electrical phosphene excitation decreased significantly by 22.4 % (p < 0.05). The critical frequency of flicker-induced phosphene in the mode 3 and 1.5 increased by 20.6 % (p < 0.05) and 47 % (p < 0.05), which indicates an increase in the functional activity of visual analyzer. Conclusions. The inclusion of the drugs Briroza and Rozacom twice a day for 2 months in the treatment of patients with secondary glaucoma is effective due to the increased functional activity of the visual analyzer and normalization of intraocular pressure in patients with secondary glaucoma.
Forms to improve the quality of postgraduate training of ophthalmologists
Authors: Rykov S.O. , Tumanova O.V. , Petrenko O.V. , Kosuba S.I.
Published: October 2021

The main direction of improving the process of professional development of doctors at the stage of postgraduate training is the gradual introduction of modern forms of education. Internship is the first step to independent work of a doctor, so it is important from this stage to direct the efforts of a young specialist to self-improvement. Traditional methods of training interns are primarily aimed at obtaining and deepening knowledge through the transfer of information with subsequent implementation in specific professional activities with recognized algorithms. However, this method of teaching does not contribute to the development of independent cognitive activity of young colleagues, although it is on this postulate the concept of distance learning is based as a new form of postgraduate education. The article characterizes the modern system of training of interns-ophthalmologists. The use of distance learning, clinical analysis of patients’ data, stage test control, situational tasks in the educational process is substantiated. Wishes are expressed to improve the organization of the internship in ophthalmology.
The relation of phacoemulsification and progression of age-related macular degeneration
Authors: Denisyuk O.U.
Published: October 2021

Background. It is currently impossible to draw definitive conclusions whether phacoemulsification (PhE) is safe for people with age-related macular degeneration (ARMD). It is not clear if PhE causes the progression of ARMD and affects visual acuity (VA). The purpose was to analyze the possible association of PhE with ARMD progression in the early and late (up to 18 months after surgery) period. Materials and methods. The study included 86 patients (93 eyes), 37 men and 49 women aged 60 to 82 years, who were operated for PhE (implantation of soft intraocular lens on the camera Infiniti, “Alcon”, USA). ARMD was assessed based on the classification of the American Academy of Ophthalmologists (AREDS, 2001). Patients were examined 1, 3, 6, 12 and 18 months after surgery. For statistical processing of obtained data, Statistica 10 (StatSoft, Inc., USA) and MedCalc Statistical Software 18 (MedCalc Software bvba, Belgium) were used. Results. In 69.9 % of eyes with cataract, ARMD was registered: early and midstage (AREDS 2 and 3) was diagnosed in 16.1 % of cases, late stage (AREDS 4.1) — in 25.8 %, and exudative (AREDS 4.2) — in 28.0 %. VA before surgery was consistent with the stage of ARMD and was worse in AREDS 4. To evaluate the progression of ARMD, the index of progression (IP) was developed characterizing the average rate of ARMD clinical manifestations change. The progression of ARMD within 18 months (IP > 0) after the PhE was observed in 33.3 % of cases, including 12.9 % of first determined ARMD. Patients without ARMD progression were 6 years younger than those that had progression (p = 0.001). When IP = 0.100, the disorder progressed at the early stages (3 months); when IP = 0.033, in the later period (12 and 18 months). After surgery, VA was significantly increased, which depended on the initial stage of ARMD (VA was worse at the late stage and in AREDS 4) and ARMD progression (VA was worse when IP > 0, and in the cases of progression when IP = 0.033, that is, with the later ARMD progression). Conclusions. The characteristics of the stages of ARMD and VA dynamics after PhE suggest a positive impact of PhE on the ARMDS progression.
Again about carbonic anhydrase inhibitors: modern aspects of the use of ICA in ophthalmology
Authors: Bezdetko P.A.
Published: October 2021

For more than 70 years, the inhibitors of carbonic anhydrase (ICA) have been used in the treatment of glaucoma. Since 1995, topical forms of ICA have appeared among antiglaucoma drugs — dorzolamide, and since 1999 — brinzolamide. The hypotensive efficacy and safety of topical ICA gave rise to the widespread use of these drugs in the treatment of various forms of glaucoma. The peculiarities of the mechanism of action made it possible to create on their basis effective fixed combinations, which allow reducing the intraocular pressure by up to 40 % in patients with glaucoma. The attractiveness of the drug has expanded due to the effect of ICA on various tissues of the organ of vision. Thus, ICAs effectively improve the hemodynamics of the eye and optic nerve. The antioxidant activity of the drug makes it possible to expand the indications for its use in patients with vascular patho-logy of the retina and optic nerve. The biomechanical characte-ristics of the drug allowed its effective and safe use in the complex treatment of macular edema of various etiologies. The adjuvant use of topical ICAs expands the possibilities of anti-VEGF therapy in the treatment of macular edema of various etiologies. Features of the action of ICA on the endothelial pump function of the cornea made it possible to formulate the rules for the use of topical ICA in patients with an insufficient function of the corneal endothelium.
Двухуровневая методика оценки эксплуатационной надежности модульной кабины с активной защитой (МКАЗ) от лазерного воздействия
Authors: Люхтер А.Б. , Криворотов В.И. , Скворцов К.В.
Published: October 2021

Выполнение обязательных требований лазерной безопасности, указанных в отечественной и мировой нормативной документации, является важнейшим фактором, определяющим широкое внедрение в промышленное производство лазерных комплексов, установок и систем, а также технологий лазерной обработки. В 2020 году целый ряд нормативных документов РФ утратил правовую силу, в частности СН 5804-91, СанПиН 2.2.4.3359-16 и др. Однако важность и актуальность решения проблемы обеспечения условий безопасной эксплуатации лазерного оборудования на отечественных предприятиях, невзирая на отсутствие этих документов в нормативно-правовом поле РФ, не вызывает сомнений. В новых проектах при разработке эксплуатационных документов лазерный генератор без средств коллективной защиты (кабин, кабинетов и др.) по-прежнему продолжают относить к 4‑му классу опасности [1–9]. При работе лазерных роботизированных комплексов (ЛРК) не исключена вероятность возникновения опасных и аварийных ситуаций: образование мощного отраженного лазерного излучения (ЛИ) от обрабатываемой поверхности; выход ЛИ за пределы обрабатываемой детали / области обработки в сторону вероятного нахождения персонала (прожиг обрабатываемой детали, неточность позиционирования, сбой программы управления). При возникновении аварийных ситуаций высока вероятность нанесения тяжелого вреда здоровью рабочего персонала лазерным излучением. По мнению авторов настоящей работы, ссылаясь на собственный опыт, а также публикации других исследователей [5–7, 10–13], лазерный генератор, используемый в составе лазерных систем (установок, комплексов и др.), оборудованный средствами коллективной активной защиты, можно с достаточным обоснованием отнести к 1‑му классу опасности.
Magnitude, Seasonal-variation, Serological and Hematological Profile of Dengue in a Tertiary Teaching Hospital, Karwar, India
Authors: Kukanur F. Sneha , Naveen G. , Chitrabanu N. Ashwin , Prashant B.M. , Meghana R. , Venkatesh V.N.
Published: October 2021

Dengue viral infection is the most widely spread arbo-viral disease in Indian subcontinent. High index of clinical suspicion especially during its peak season can be rewarding in diagnosing as well as early case management of anticipated DHF and DSS cases. To estimate the magnitude, seasonal-variation, serological as well as hematological aspects of dengue cases. This was a prospective observational study held in Microbiology and Hematology laboratories of our hospital for duration of one year from July-2019 to June-2020. All the suspected dengue cases were subjected to NS1-antigen, IgM and IgG antibody detection. The samples were also tested for platelet count, total count, haematocrit as well as hemoglobin estimation. All 1,550 dengue suspected cases were subjected to serological testing, among which 157 (10.1%) were positive. The most affected populations were the adult male. As the study was conducted for one year, we could observe the seasonal trend which peaked during post-monsoon. Out of 157 cases, 81.5%, 0.6% and 17.8% were determined as primary, secondary and old dengue cases respectively. There was a significant association between NS1 antigen and fever of </= 5 days duration with ‘p’ value< 0.00001. Thrombocytopenia, leucopenia and increased haematocrit were witnessed in 15.9%, 28.6% and 35% respectively. Our study shows that we had a high magnitude of primary cases that are prone to secondary dengue infection which might have a catastrophic effect giving rise to DHF, DSS or SD.
Plant-microbe Interactions in Rhizospheric soil Treated with Different Quality Organic Residues
Authors: Somboon Saowalak , Kamolmanit Bhanudacha , Lawongsa Phrueksa
Published: October 2021

The objective of this research was to study plant-microbe interactions in rhizospheric soil treated with different quality organic residues in short-term incubation of the soil and subsequent planting of maize crop. The treatments combinations were, 1) untreated soil (control; CT), 2) groundnut stover (GN) with high nitrogen (N) but low lignin (L) and polyphenol (PP), 3) tamarind leaf and petiole litter (TM) with medium N, L and PP, 4) rice straw (RS) with low N, L and PP but high cellulose, 5) GN+TM, 6) GN+RS and 7) TM+RS. Single and mixed residue additions of GN and TM, both high and intermediate quality, resulted in higher soil microbial properties and nutrients than the application of RS as a low quality. Accordingly, the application of the former group increased microbial abundances (i.e., bacteria, archaea, and fungi), elevated the enzymes related to the decomposition of organic residue (i.e., invertase, protease, phenoloxidase and peroxidase activity), and enhanced soil nutrients and plant growth. The results indicated that the chemical compositions (N, L, and PP) of the organic residues amendment are key factors regulating soil microbial abundance and enzyme activity both in after incorporation and after planting. Moreover, bacterial and archaeal abundance, and microbial activities including soil respiration, invertase, protease, and peroxidase activity in the soil after planting higher than those in the soil before planting.
The Effect of Sayeok-san for Insomnia: A Systematic Review and Meta-Analysis
Authors: Huh Tae-young , Ha Da-jung , Kim Kyoung-min
Published: October 2021

Objectives: This study evaluated the effectiveness of Sayeok-san for treating insomnia.Methods: We conducted a search using keywords, such as “Sayeoksan", “Si-ni-san", and “insomnia" in eight databases (CNKI, Wanfang, Pubmed, Embase, Cochrane, NDSL, OASIS, RISS) on July 17, 2012. There was no limit placed on the publication period of the papers, and we used Cochrane’s risk of bias tool to assess their quality. Meta-analysis was classified according to the outcome measurements, such as total effective rate and PSQI.Results: Nine RCTs were selected. Meta-analysis showed that the treatment group, which used Sayeok-san, had a higher total effective rate than did the control group that used only Western medicine. The treatment group also had a lower average of PSQI and TSS (TCM symptom score) than did the control group.Conclusion: This study suggests that Sayeok-san is effective in treating insomnia. However, these findings should be interpreted cautiously due to unknown or high risk of bias of the included trials.
Safety of Korean Medicine Treatment in Patients Vaccinated with the AstraZeneca COVID-19 Vaccine (ChAdOx1 nCoV-19/AZD1222): A Case Series
Authors: Kang Sung-woo , Hong Sung-eun , Park Ji-won , Kwon Seungwon , Yoon Sang-hyub , Kim Kwan-il , Lee Beom-joon , Jung Hee-jae
Published: October 2021

Objectives: The purpose of this study is to examine the safety of Korean medicine treatment in patients vaccinated with the AstraZeneca COVID-19 vaccine (ChAdOx1 nCoV-19/AZD1222).Methods: We investigated patients at Kyung Hee University Korean Medicine Hospital who were vaccinated with the AstraZeneca COVID-19 vaccine between June 1, 2021 and June 30, 2021. The safety of Korean medicine treatment was evaluated by examining adverse events that occurred within seven days of vaccination, including liver function and kidney function testing, assessment of the severity of adverse events, and examination of causality to vaccines and Korean medicine treatment.Results: Eleven patients vaccinated with the first dose of the AstraZeneca COVID-19 vaccine were included. A total of 19 adverse events were reported: 15 systemic adverse events, three local adverse events, and one alanine aminotransferase increase. The most commonly reported systemic adverse events were fatigue (4 cases, 36.4%), headache (4 cases, 36.4%), and myalgia (4 cases, 36.4%). All adverse events were rated below moderate (grade 2) in severity. Systemic and local adverse events were evaluated as definitely related to vaccination and unlikely to be related to Korean medicine treatment, while alanine aminotransferase increase was evaluated as unlikely to be related to either the vaccine or Korean medicine treatment. Aspartate transaminase, Blood urea nitrogen, and creatinine were measured within the reference range after vaccination.Conclusion: Our results suggest that the severity and frequency of adverse events in patients vaccinated with the AstraZeneca COVID-19 vaccine did not increase after Korean medicine treatment.
A Study on the Hypoglycemic Effect and Safety of Combined-Therapy of Baekhogainsam-tang and Hypoglycemic Agent for Type 2 Diabetes Mellitus Patients without Complications: A Systematic Review and Meta-Analysis
Authors: Shin Jae-ik , Baek Ji-soo , Shin Seon-mi , Cho Chung-sik
Published: October 2021

Objectives: The purpose of this study is to assess the efficacy and safety of Baekhogainsam-tang for type 2 diabetes without complications by systemic review and meta-analysis of randomized controlled trials (RCTs).Methods: For a systematic review and meta-analysis, we set a key question in accordance with PICOT-SD. We searched the following up to March 31. 2021: PubMed, EMBASE, The Cochrane Library, CNKI, CiNii, KISS, KMBASE, OASIS, and ScienceON. A meta-analysis was conducted by synthesizing the results, including fasting plasma glucose level, postprandial 2-hour plasma glucose level, and Glycated Hemoglobin (HbA1c).Results: A total of five trials are included in this systemic review. The treatment group (Baekhogainsam-tang plus conventional treatment) showed more statistically significant effect than did the control group (conventional treatment only) in fasting plasma glucose level, postprandial 2-hour plasma glucose level, and glycated hemoglobin (HbA1c).Conclusions: Baekhogainsam-tang showed statistically significant effects in hypoglycemic effect and in improving insulin resistance. However, the number of studies included in the meta-analysis was insufficient, and the BIT used in the included studies was not standardized. This topic requires further attention and more clinical research.
A Case Report of Abdominal Pain Relief in a Patient with Metastatic Colorectal Cancer Treated with Korean Medicine
Authors: Yoon Mi-jung , Kim Na-yeon , Choi Hong-sik , Kim Seung-mo , Kim Kyung-soon
Published: October 2021

Objectives: The aim of this case report is to present abdominal pain relief in a patient diagnosed with colorectal cancer with several organ metastases.Methods: The patient was treated with herbal medicine, acupuncture, and moxibustion. The effect of the treatment was measured by a numeric rating scale (NRS).Results: The NRS of the patient’s abdominal pain was reduced after Korean medicine treatment.Conclusions: This case report suggests that Korean medicine may be effective for treating abdominal pain in cancer patients. However, additional study is needed to confirm interactions between Korean medicine and the control of abdominal pain.
Evaluation of the Biological Control Agent’s Efficiency Against the Causal Agent of Early Blight of Solanum melongena
Authors:   Department of Plant Protection, College of Agriculture, University of Basra, Iraq, Abbdul Ameer Matrood Abdulnabi , Rhouma Abdelhak ,   Higher Agronomic Institute of Chott Mariem Sousse, University of Sousse, Tunisia, Okon Okon Godwin ,   Department of Botany, Faculty of Biological Sciences, Akwa Ibom State University, Nigeria
Published: October 2021

Eggplant, an important vegetable crop in Iraq, faces yield losses due to early blight disease caused by Alternaria solani. Two antagonistic fungi (Aspergillus niger and Purpureocillium lilacinum) isolated from eggplant rhizosphere were tested in vitro (dual confrontation technique) and in vivo (preventive treatments) as potential bioagents against the most virulent A. solani isolates. A. niger and P. lilacinum at 30% conidia/ml exhibited high inhibitory rate (55.11%) against A. solani mycelial growth. Furthermore, these two antagonistic species when applied preventively at 30% of the stock conidial suspension in vivo, reduced significantly disease severity index (<28.41%). Moreover, A. niger (11.98 units/g of soluble protein) and P. lilacinum (8.11 units/g of soluble protein) enhanced the polyphenol oxidase activity. Based on the results obtained by this study, it appears that A. niger and P. lilacinum could be employed as foliar treatments against A. solani to promote eggplant growth and development and induce plant systemic resistance. To control A. solani, it is encouraged to use natural enemies as components in integrated disease management. Keywords: Alternaria solani, biological control, polyphenol oxidase, Solanum melongena, antagonistic fungi
First Record of the Parasitoid Buquetia musca (Robineau-Desvoidy, 1847) on Papilio machaon (Linnaeus, 1758) Larvae aAlong the Syrian Coast
Authors:   Plant Protection Department, Faculty of Agriculture, Teshreen University, Lattikia, Syria, Ahmad Israa , Ramadan Ali Mohamad ,   Plant Protection Department, Faculty of Agriculture, Teshreen University, Lattikia, Syria, Aslan Louay ,   Faculty of Agriculture, Department of Plant Protection, Damascus  University, Syria, Khatib Nadia Ibrahim ,   Department of Biological Control , Agriculture Directorate, Lattikia, Syria
Published: October 2021

Larvae samples of Papilio machaon (Linnaeus, 1758) were collected along with its host plant Foeniculum from Tartous governorate (Baniyas and Al Qadmous), Syria during the autumn of 2019. Samples were examined at the Laboratory of Entomology, Faculty of Agriculture, Tishreen University. The larvae were reared and observed at 25±1°C, 60±5% RH, and 16 hr light: 8 hr dark photoperiod, until the emergence of either the parasitoid, Buquetia musca (Robineau-Desvoidy, 1847) (Diptera: Tachinidae) or the host adults. The parasitoid larvae emerged from the 5 th instar larvae and/or pupal stage. The pupal developmental period was 11.7±1.32 days (n= 13) and adult longevity was 6.2±2.3 days (n= 13). Keywords: Tachinid flies, Buquetia musca, Papilio machaon, Syrian coast
First Report of Variegated Caper Bug (Stenozygum coloratum Klug, 1845) on Sunflower (Helianthus annuus L.) in Syria
Authors:   General Commission for Agricultural Scientific research, Tartous, Syria, Ali Ali Yassine
Published: October 2021

The caper plant is the main host for the variegated caper bug Stenozygum coloratum (Klug, 1845) along the Syrian coast. The plants loose most of their leaves due to high infestation with this bug. The different stages of this bug were observed to feed on the vegetative parts of sunflower, Helianthus annuus L., in high numbers (75 to 120 bugs/plant). The symptoms of infestation were white spots on the leaf surface. This report includes information on morphological characteristics of the bug, as well as plant hosts, and reporting sunflower as a new plant host for this insect. Keywords: Stenozygum coloratum, Sunflower, Helianthus annuus, New host plant. Syria
Bacterial biofilms: formation, advantages for community members, clinical implications, and antibiotic resistance
Authors: Aliane Samia , Meliani Amina
Published: October 2021

Microbial biofilms offer several advantages to cells forming the biofilm community, such metabolic cooperation, genetic diversity, protection against environmental hostilities and a high resistance and tolerance potential. In addition, biofilm-forming bacteria present the most important cause of infection in human. Biofilm-assciociated infections are characterized by the development of biofilm in human tissues or medical devices, which makes these infections more difficult to cure and helps bacteria to acquire new pathogenesic features such as antibiotic resistance. Antibiotic resistance is considered as the most important threat for global health, which affects the treatment outcomes, costs, disease extention, and illness duration. In this review, we discuss an overview of biofilm formation, and advantages ensured to microbial cells. Furthermore, clinical implications of biofilms and antibiotic resistance profiles acquired are also highlighted.
Amelioration of ethanol intoxicated ovarian dysfunction by Alocasia indica tuber: possible involvement of nuclear factor kappa B
Authors: Pal Swagata , Bhattacharjee Ankita , Banerjee Oly , Prasad Shilpi K. , Singh Siddhartha , Mukherjee Sandip
Published: October 2021

The protective efficacy of ethanolic extract of Alocasia indica tuber was studied on ethanol-intoxicated ovaries of rats, searching for the possible involvement of expression levels of nuclear factor kappa B (NF‑κB) and caspase‑3. The extract was prepared by 80% ethanol using Soxhlet. Female albino rats were intraperitoneally injected by ethanol (3 g kg‑1 body weight per day) with and without extract (200 and 400 mg kg‑1 body weight per day) for a period of 14 days. Oxidative stress parameters and the gonadal hormone profile were determined, and apoptosis assay and immuno-staining of NF‑κB and caspase‑3 were conducted. Oxidative stress parameters and antioxidant enzyme levels were regained by 41 to 90% and 36 to 96%, respectively, by extract at a higher dose in ethanol intoxicated rat. Decreased levels (18 to 28%) of follicle stimulating hormone, luteinizing hormone, estrogen and progesterone level due to ethanol intoxication were restored (19 to 98%) by extract at same dose, whereas elevated level of prolactin and corticosterone level were restored by 51 to 81%. The extract reduced number of apoptotic dead cells in the ovary with altered expression of NF‑κB and caspase‑3, indicated by lower number of positively stained cells in extract-treated rats. It appears that ethanolic extract of A. indica can suppress ethanol-induced ovarian apoptotic cell death and other reproductive changes.
Personalizing Evidence for Shoulder Fracture Patients Using an Extended Instrumental Variable Causal Forest Algorithm
Authors: Brooks John M. , Chapman Cole G. , Floyd Sarah , Chen Brian K. , Thigpen Charles A. , Kissenberth Michael
Published: October 2021

Objective: To assess the ability of an extended Instrumental Variable
Causal Forest Algorithm (IV-CFA) to provide personalized evidence of
early surgery effects on benefits and detriments for elderly shoulder
fracture patients. Data Sources/Study Setting: Population of 72,751
fee-for-service Medicare beneficiaries with proximal humerus fractures
(PHFs) in 2011 who survived a 60-day treatment window after an index PHF
and were continuously Medicare fee-for-service eligible over the period
12 months prior to index to the minimum of 12 months after index or
death. Study Design: IV-CFA estimated early surgery effects on both
beneficial and detrimental outcomes for each patient in the study
population. Classification and regression trees (CART) were applied to
these estimates to create patient reference classes. Two-stage least
squares (2SLS) estimators were applied to patients in each reference
class to scrutinize the estimates relative to the known 2SLS properties.
Principal Findings: This approach uncovered distinct reference classes
of elderly PHF patients with respect to early surgery effects on benefit
and detriment. Older, frailer patients with more comorbidities, and
lower utilizers of healthcare were less likely to gain benefit and more
likely to have detriment from early surgery. Reference classes were
characterized by the appropriateness of early surgery rates with respect
to benefit and detriment. Conclusions: Extended IV-CFA provides an
illuminating method to uncover reference classes of patients based on
treatment effects using observational data with a strong instrumental
variable. This study isolated reference classes of new PHF patients in
which changes in early surgery rates would improve patient outcomes. The
inability to measure fracture complexity in Medicare claims means
providers will need to discuss the appropriateness of these estimates to
patients within a reference class in context of this missing
information.
Esophageal atresia associating gastrointestinal malformations: a study of clinical approach
Authors: Iozsa Dan , Costea Andreea , Ionescu Nicolae
Published: October 2021

Digestive tract malformations requiring surgical repair in association with esophageal atresia are rare occurrences. Because of this uncommon presentation of esophageal atresia, its evaluation and management are often difficult, requiring extensive workup and multiple surgical procedures. We present our experience with esophageal atresia associating gastrointestinal congenital anomalies in the last 10 years. Clinical and surgical perspectives were pointed willing to make relevant observations in matters of diagnosis and treatment strategy in these patients. Therefore, 7 cases resembling this pattern were identified – duodenal atresia and anorectal malformation being the most common coexistent malformations. All the cases exhibited technical and procedural staging difficulties that we shaped according to the patient’s general picture in the absence of a standardized approach. Careful preoperative follow-up, multidisciplinary communication, watchful waiting and an individually patient-shaped approach are elementary requirements for good outcomes in complex cases of EA.
Fractional-order iterative learning control for robotic Arm-PD2Dα type
Authors: Cvetkovic Bosko , Lazarevic Mihailo
Published: October 2021

In this paper, a new open-loop PD2D? type a fractional order iterative
learning control (ILC) is studied for joint space trajectory tracking
control of a linearized uncertain robotic arm. The robust convergent
analysis of the tracking errors has been done in time domain where it is
theoretically proven that the boundednesses of the tracking error are
guaranteed in the presence of model uncertainty. The convergence of the
proposed open-loop ILC law is proven mathematically using Gronwall integral
inequality for a linearized robotic system and sufficient conditions for
convergence and robustness are obtained.
On the approximations of solutions to stochastic differential equations under polynomial condition
Authors: Djordjevic Dusan , Jovanovic Miljana
Published: October 2021

The subject of this paper is an analytic approximate method for a class of
stochastic differential equations with coefficients that do not necessarily
satisfy the Lipschitz and linear growth conditions but behave like a
polynomials. More precisely, equations from the observed class have unique
solutions with bounded moments and their coefficients satisfy polynomial
condition. Approximate equations are defined on partitions of a time
interval, and their coefficients are Taylor approximations of the coefficients
of the initial equation. The rate of Lp convergence increases when degrees
in Taylor approximations of coefficients increase. At the end of the paper, an
example is provided to support the main theoretical result.
Almost convergence of complex uncertain double sequences
Authors: Das Birojit , Tripathy Binod , Debnath Piyali , Bhattacharya Baby
Published: October 2021

Convergence of real sequences, as well as complex sequences are studied by B.
Liu and X. Chen respectively in uncertain environment. In this treatise, we
extend the study of almost convergence by introducing double sequences of
complex uncertain variable. Almost convergence with respect to almost
surely, mean, measure, distribution and uniformly almost surely are
presented and interrelationships among them are studied and depicted in the
form of a diagram. We also define almost Cauchy sequence in the same format
and establish some results. Conventionally we have, every convergent
sequence is a Cauchy sequence and the converse case is not true in general.
But taking complex uncertain variable in a double sequence, we find that a
complex uncertain double sequence is a almost Cauchy sequence if and only if
it is almost convergent. Some suitable examples and counter examples are
properly placed to make the paper self sufficient.
Aplicación del diseño de prácticas pedagógicas basadas en metodología STEM en tecnología, innovación e industria 4.0
Authors: Duque Suárez Oscar Manuel , Duque Suárez María Carolina , Restrepo Chaustre Yesenia
Published: October 2021

Para mejorar los índices de educación, innovación y desarrollo en la población, resulta nece- sario que las instituciones educativas estatales, junto con los entes gubernamentales trabajen de forma incorporada y proactiva en el diseño de planes, programas, proyectos y políticas que, conjuntamente con las metas, permitan, en breve, mediano y largo plazo beneficios que proporcionen el desarrollo armónico para conseguir una región más competitiva, es decir, un mejor nivel de vida para su población de forma generalizada. Lograr que la educación en las ciudades sea más competitiva, equitativa y justa conlleva que su desarrollo se debe basar en la innovación tecnológica y en el emprendimiento para poder robustecer las empresas, las insti- tuciones de conocimiento.

Es aquí donde se genera la intención de implementar estrategias, como la elaboración de se- milleros en tecnología e innovación en los colegios de las ciudades del país, que proporcionen escenarios para que los estudiantes de las instituciones educativas se involucren en la investigación que fortifique el progreso y mantenimiento de grupos de investigación, además de fortalecer sus aptitudes básicas orientadas a la investigación, incorporando el perfeccionamiento de la investigación a temprana edad; también mejorar su proyección vocacional identificando y planteando soluciones a problemas del entorno, fortaleciendo la productividad junto a la competitividad en la ciudad y el país. En este escrito se realiza la presentación de los casos de estudio realizados en Tecnoacademia Cúcuta, aplicados en diferentes escenarios de aprendizaje generando proyectos de formación utilizando la metodología STEM (Sciences, Technology, En- gineering and Mathematics).
Średniowieczny kościół Świętego Wojciecha na Zawodziu w Kaliszu — badania i interpretacje
Authors: Wyczółkowski Dariusz
Published: October 2021

Celem artykułu jest przedstawienie informacji o początkach kościoła Św. Wojciecha w Kaliszu funkcjonujących dotychczas w literaturze oraz próba ich weryfikacji. Tytułowa świątynia leży na terenie przygrodowej osady Kalisz Zawodzie. Z uwagi na bliskość grodu oraz wezwanie badacze zaliczali go do najstarszych, jedenastowiecznych kościołów parafialnych w Kaliszu. Powtórna analiza źródeł pisanych pozwoliła na przesunięcie daty jego powstania na XII–XIII w. Z kolei dalsze uściślenie czasu wzniesienia świątyni — po połowie XII w. było możliwe dzięki analizie wyników dawnych i nowszych badań archeologicznych prowadzonych wewnątrz kościoła i na terenie cmentarza przykościelnego. Dostarczyły one dowodów, żebudowlę wzniesiono na terenie osady użytkowanej od X do przełomu XII i XIII w.
ANÁLISIS DE LOS MÉTODOS DE AMORTIZACIÓN UTILIZADOS EN ARGENTINA, CHILE Y PERÚ
Authors: Buelvas Parra John Arturo , Estrada Marrugo Sindy , Genes Luna Eliana , Sierra Rojas Mariana
Published: October 2021

Al momento de amortizar créditos, alrededor del mundo existen muchos sistemas para hacerlo, que van desde el alemán, americano, hasta el francés, cada uno con características y efectos diferentes, pero que su finalidad es la misma al momento de conceder o adquirir una deuda. Centrándonos en américa latina, se escogieron tres países como punto de análisis Argentina, Chile y Perú, cada uno con monedas diferentes, normatividad contable y financiera diferente, pero con algo en común, ya que en los tres casos existe un patrón en los cuales los bancos  quieren obtener una ventaja mayor al escoger el sistema por el cual se quiere amortizar el crédito. Cada método de amortización en los diferentes países puede tener una connotación distinta, pero como punto referencial se observa que en los tres casos el comportamiento de los acreedores está encaminado a buscar siempre el uso del sistema francés aunque no se descartan en algún caso el uso del sistema alemán y americano. Las operaciones crediticias en los países de una u otra forma permiten seguir con actividades económicas o de otra índole, cada país es autónomo en la decisión de escoger la forma en como amortizan sus créditos, encauzando al sistema bancario y financiero a maximizar su rentabilidad, pero buscando siempre que exista una regulación por esa razón al momento de acceder a un crédito se debe tener en cuenta las características y condiciones que presenta cada sistema de amortización para liquidar el crédito y así escoger la más conveniente para las partes.Palabras Claves: Métodos, Amortización, Créditos, Sistemas de amortizar, Decisión.
EL MALTRATO, VIOLENCIA Y DELINCUENCIA JUVENIL EN EL MUNICIPIO DE SINCELEJO
Authors: Manjarres Marquez Jose Alexander
Published: October 2021

Objetivo: Se hizo un análisis de la Juventud, en el municipio de Sincelejo en el tema de delincuencia y maltrato a los jóvenes en un rango de edades desde 6 años hasta los 18 años, cuáles son las afectaciones de este indicador en  este sector. Métodos: se utilizó la estadística de la población afectada y análisis en el tiempo establecido, con proyecciones en algunos indicadores Resultados: el estudio nos muestra el comportamiento de los problemas familiares y extra familiares de los jóvenes del municipio de Sincelejo, cuales en las cifras con más deterioros en el hogar y su personalidad para el desarrollo de sus actividades. Se utilizó una encuesta de 37 preguntas de fácil comprensión y resolución que permite obtener información acerca de la edad, grado escolar, sexo, conformación familiar, grado de escolaridad de las familias y convivencia familiar; conocimiento de la Ley y Programas de Juventud, e interés y compromiso por vincularse a agremiaciones juveniles. Conclusiones: Es posible que la implementación inmediata de políticas públicas en ayuda de los jóvenes y programas de capacitación en cuanto a recreación y deporte, salud, emprendimiento y una vida sana o establecer proyecto de vida
Comunicación y salud
Authors: Cardozo Mariela Rosana , Gianfrini Maria Flor
Published: October 2021

Al indagar en el campo Comunicación y Salud observamos un desequilibrio entre las prácticas profesionales -en aumento y consolidación-, y la escasa reflexión sistemática sobre estas. Por ello, nos proponemos a partir de una experiencia concreta, esbozar interrogantes, y reflexiones que permitan comprender dónde nos encontramos y hacia dónde vamos. En este trabajo reflexionaremos sobre la investigación en comunicación y salud tomando como punto de partida la experiencia del Taller de Trabajo Integrador Final de la Especialización en Comunicación y Salud de la Facultad de Periodismo y Comunicación Social de la Universidad Nacional de La Plata, en el período 2015-2020. En dicho espacio apuntamos a promover la investigación en comunicación y salud problematizando las prácticas profesionales para producir conocimiento.
OUR EXPERIENCE TO DISCOVER THE ESSENCE OF PEDAGOGICAL FACILITATION
Authors: Samvel Asatryan Miopap
Published: October 2021

Today, the changes of the education system conditioned by the new strategy of education are aimed not only at the modernization of the content and methodological tools of education but also at the reconstruction of the whole characteristic /structure/ of the subject implementing those changes. In this article, we have tried to present pedagogical facilitation in the context of modern education, the requirements for a pedagogue who has mastered the technology of facilitation, the content of the pedagogue-facilitator activity, and the research carried out in two stages reveals how the image of the facilitator-teacher is perceived in the students' consciousness. The quantitative and qualitative features of the facilitator-pedagogues were given.
POLITICAL DISCOURSE OF MODERNIZATION AND ITS DEVELOPMENTS
Authors: SHIRINYAN LEVON , SHIRINYAN TATEVIK
Published: October 2021

Every state during some historical period stands before the choice of becoming modern via modernization. There comes the problem of modernization theory which is vital for both political ideas and comprehensive development of the Republic of Armenia. The issue lies in the ways of modernization: to become modern via Westernization, or relying on the own cultural base? There comes the necessity of political discourse.
Self-Disclosure: A Psychological Analysis
Authors: Arslan Serhat
Published: October 2021

Self-disclosure is defined as the process of expressing one's feelings and thoughts about oneself to others. It is now extensively studied by social and clinical psychologists interested in self-disclosure, interpersonal communication and close relationships. Questions about why people self-disclose have led to significant research and theory generation over the years. Little attention has been paid, however, to the potential biological underpinnings of this complex behavior. Although situational factors have a significant impact on communication patterns in close relationships, individual differences can be observed even in the face of strong social-situational stimuli. Self-disclosure is seen as a healthy personality structure and sign. It appears to be a relatively stable personality trait associated with positive personality traits. The aim of this research is to examine the concept of self-disclosure from a psychological perspective.