bluuebunny/crossref_metadata_2025 huggingface dataset:
Sosyal Medya Kullanıcılarının Satın Alma Tercihlerinde Influencer Pazarlamasının Etkisi
Authors: YILDIZ Selçuk Yasin
Published: December 2021

Sosyal medyanın bir parçası olarak son dönemde popülerleşen influencer pazarlaması firmaların ve tüketicilerin dikkatini üzerine toplamış durumdadır. Sürekli bir pazarlama faaliyetinde bulunma gerekliliği duyan firmaların, influencerlar aracılığıyla tüketicilere ulaşabilmeleri pazarlama açısından yeni bir çığır açmıştır. Influencerların tüketici davranışını nasıl etkilediğini araştıran çalışmalar son zamanlarda artan düzeyde ilgi görmesine rağmen, bu faaliyetlerin gerçekte tüketicilerin ödeme istekliliğini ne derecede etkilediği üzerine literatürde herhangi bir bilgi bulunmamaktadır. Dijitalleşen pazarlama uygulamaları kapsamında firmalar, kaynak güvenilirliğinden faydalanmak amacıyla sosyal medya influencerları ile ortak projeler yürütmektedir. Bu iş birliklerinin sonucunda firmalar; influencerların görselliği, güvenirliği ve uzmanlığı sayesinde, tüketicilerde satın alma niyetinin oluşmasını sağlamayı ve tüketicilerin daha fazla ödeme istekliliğine sahip olmalarını istemektedir. Bu çalışmanın amacı, sosyal medyada influencerların tüketicilerin ödeme istekliliğini artırıp artırmadığını belirlemektir. Kaynak Güvenilirliği Modeli’ne dayanarak incelenmekte olan bu çalışmada incelenen veriler, sosyal ağ platformlarından Instagram kullanan bireylerin takip ettikleri fenomenler temel alınarak toplanmıştır. Analiz sonuçlarına göre, erkek influencerların uzmanlığı ve güvenirliği ile kadın influencerların çekiciliği ve uzmanlığı tüketicilerin ödeme istekliliğini artırmada bir unsur olarak karşımıza çıkmaktadır. Yapılan çok değişkenli istatistiksel analiz sonuçları, firmalara ve uygulamacılara yönetimsel çıkarımlarda bulunmaktadır. Tüketicilerin bakış açısına göre, uzmanlık özellikleri yüksek olan erkek influencerlar ve çekicilik özellikleri yüksek olan kadın influencerlar ile çalışılması, pazarlama faaliyetlerinden daha yüksek faydanın elde edilmesine katkı sunabilir.
Çanakkale Kentinin Markalaşması ve Marka İmajının Ölçümü
Authors: GÖRÜN Mustafa , ADIGÜZEL EMİR Fatma
Published: December 2021

Küreselleşmeyle birlikte artan rekabet koşulları kentlerinde birbirleriyle rekabet etmesini gündeme getirmiştir. Rekabet ortamındaki kentler, diğer kentler arasında farklılıklarını ortaya koyarak, tercih edilebilirliklerini arttırabilmek için markalaşma çalışmaları yürütmeye başlamıştır. Kentlerin bu markalaşma sürecinde imaj unsuru ön plana çıkmaktadır. Kent imajı, insanlar tarafından kentin nasıl algılandığını ifade eden bir kavramdır. Kentte bulunan imaj unsurları kentlerin markalaşarak gelişmesine katkı sağlayacaktır. Dolayısıyla bir kentin markalaşması çalışmaları yürütülürken öncelikle imaj unsurlarının tespit edilmesi markalaşma aşamasında yararlı olacaktır. Bu çalışmada, Çanakkale’nin kent markası ve marka imajının ölçülmesi hedeflenmiştir. Bu doğrultuda yapılan anket çalışması ile Çanakkale kentinin markalaşmasına katkı sağlayan unsurların neler olduğu ve kent imajının hangi düzeyde olduğu ölçülmeye çalışılmıştır. Yapılan araştırma sonucuna göre, Çanakkale kentinin markalaşmasına en çok katkı sağladığı düşünülen unsur Çanakkale’nin “tarihi zenginliğinin olması”dır. Çanakkale kentinin markalaşmasına en çok katkı sağladığı düşünülen turizm destinasyonu olarak “Tarihi Alan (Şehitlik)” sonucuna ulaşılmıştır. Çanakkale’nin kent imajı algısının ise “iyi” yönde olduğu sonucuna ulaşılmıştır.
Examining the leadership styles among High School teachers at Dominican schools in Indonesia
Authors: Hermawan Agus
Published: December 2021

Spiritual leadership in the education field is not something new. However, it has not been deeply examined. The studies on spiritual leadership are more easily found in the non-educational than in educational fields (Scott & Tweed, 2016). For that reason, drawing on spiritual leadership and Dominican spirituality, the researcher examined how Dominican Schools in Indonesia integrate Dominican spirituality and leadership in their teaching performances. A leadership styles (Lewin’s leadership styles) questionnaire and collaborative leadership survey through Google form was conducted to collect data from 114 high school teachers of six Dominican Schools in Indonesia. The study results were a) Dominican spirituality provides unity of leadership styles among the high school teachers at Dominical Schools, b) leadership styles adopted by teachers are in line with Dominican spirituality leadership. Therefore, a positive correlation between Dominican spirituality and educational leadership was rooted in the values and vision of Dominican Educational Institution and became an educational leadership identity among high school teachers. The researcher suggests that curriculum designers and education facilitators collaborate to include and practice Dominican spiritual leadership as one of the principles and visions in Dominican educational institutions. It can also be used to describe other institutions with similar charisms. This study also advises that future researchers perform a poll on "Dominican Spiritual Leadership" using quantitative research methodologies. It is necessary to investigate the relationship between Dominican spiritual leadership and other educational characteristics in-depth. Educational levels, teaching experience, gender, community culture, and other factors may influence stakeholders in Dominican schools and other educational institutions worldwide.
Rancang Bangun Sistem Akses Rumah Indekos Menggunakan QR Code Berbasis Mikrokontroler dengan Payment Reminder System pada Aplikasi Android
Authors: Kartina Aisyah Nanda , Kusumawardani Mila , Saptono Rachmad
Published: December 2021

Rumah indekos merupakan tempat tinggal sementara dan dijadikan sebagai tempat untuk menyimpan barang-barang berharga. Salah satu sarana yang perlu ditingkatkan adalah keamanan pagar dan pintu rumah, karena rumah seringkali menjadi sasaran bagi orang yang ingin berbuat kejahatan, sehingga sistem keamanan sangat dibutuhkan. Salah satu cara yang bisa dilakukan untuk mengamankan pagar dan pintu rumah adalah menggunakan kunci pintu digital. Sistem keamanan pada kunci pintu rumah disaat ini mayoritas ialah sistem keamanan manual berbentuk kunci gembok konvensional.
Penelitian ini bertujuan untuk melakukan pengembangan sebuah sistem untuk memberikan tingkat akurasi keamanan yang lebih baik pada pintu kamar dan pagar indekos, dan sistem pengingat waktu pembayaran agar pembayaran indekos lebih terkontrol. Untuk membuka pagar dan pintu kamar penghuni indekos melakukan pemindaian kode QR dengan aplikasi android sehingga dapat mengakses pagar dan pintu kamar tersebut. Penghuni indekos yang statusnya belum membayar uang sewa akan diberi peringatan berupa pop up di aplikasi android.
Setelah dilakukan pengujian sistem miniatur rumah indekos, maka didapatkan hasil pengujian yaitu berupa keberhasilan uji fungsionalitas miniatur rumah indekos yang telah dibuat, uji fungsionalitas aplikasi SmartKos pada smartphone android, database firebase, dan keakuratan komunikasi data antara firebase dan NodeMCU berupa delay dengan nilai terburuk pada pengukuran ke-3 dengan nilai 3.89 detik, throughput yang paling baik adalah pada pengukuran ke-3 dengan nilai 43864 bps, packet loss pada penelitian ini memiliki indeks 4 karena memiliki nilai packet loss sebesar 0%.
Garage Control and Monitoring System using Fuzzy Logic Method Based on User Distance and Speed
Authors: Rochmah Aida Ulfia , Junus Mochammad , Imammuddin Azam Muzakhim
Published: December 2021

The increase in private vehicles number will also increase the number of crimes such as vehicle theft. So the owner must have a garage to increase security. However, generally security systems still use standard security. So, a system was developed to improve security and make it easier to be more effective using the ESP32 microcontroller to process the user's distance and speed values ??to control the rolling door using fuzzy logic, monitor whether or not vehicles are in the garage through a smartphone application, manage the queuing system on the smartphone application and find out the quality of the network used. Data retrieval is done by testing the hardware performance, namely the MG996R Servo Motor, ultrasonic sensor HC-SR04, Magnetic Switch MC-38, Infrared Sensor, Buzzer Module, and 1W HPL LED and the performance of smartphone application software made using Android Studio. From the test results, the speed of the servo motor with forward rotation is obtained from fuzzy logic processing to get the maximum and minimum values. A monitoring system to determine the presence or absence of a car in the garage by utilizing the color change of the view on the smartphone application. In automatic mode the smartphone application uses a queue system, where only one user can use the application, so other users cannot access the smartphone application and receive notifications. Based on the ITU-T standard, network quality testing (QOS) using wireshark software with parameters delay, packet loss and throughput gets a very good category value.
Evaluation of YouTube Videos as a Source of Information on Non-Invasive Prenatal Testing
Authors: Yener Cem , Ates Sinan
Published: December 2021

Aim: Non-invasive prenatal testing is a method that determines the risk of a fetus being born with certain genetic abnormalities. In this study, we aimed to examine the quality of information on YouTube for non-invasive prenatal testing.

Methods: The term "Non-invasive prenatal testing" was entered in the YouTube search bar on May 1, 2021, and the top 50 YouTube videos of the non-invasive prenatal testing with the highest number of views were recorded after the exclusion of videos with a non-English language, videos repeated twice and irrelevant videos. Length of the videos, likes, and dislikes were recorded. Videos were evaluated by two obstetricians. A questionnaire consisting of 9 dichotomous questions was conducted to assess whether there was adequate information about non-invasive prenatal testing. In addition, video quality was evaluated with the Global Quality Scale, the Patient Education Materials Assessment Tool and the Journal of the American Medical Association Benchmark Criteria.

Results: The mean Global Quality Scale was 2.96±0.62. Most videos answered the question: ‘What is non-invasive prenatal testing?’ (94%), and ‘How is non-invasive prenatal testing done?’ (82%). However, there was a lack of information about the limitation of non-invasive prenatal testing in certain situations (only %16 of videos answered limitations of non-invasive prenatal testing). Three (6%) of the videos had misinformation. The mean Global Quality Scale was 2.96±0.62. The Patient Education Materials Assessment Tool mean value was 72% and 58% in terms of understandability and actionability, respectively. The mean Journal of the American Medical Association Benchmark Criteria score was found as 1.4±0.8.

Conclusion: The videos posted about non-invasive prenatal testing on YouTube were of poor-moderate quality. If the quality of the videos increases, patients can have sufficient and accurate information about non-invasive prenatal, especially during these pandemic days.

Keywords: health information, prenatal diagnosis, online systems
Evaluation of the Knowledge Level of Family Medicine Residents about Mammography and Breast Cancer Screening Programs
Authors: Koc Ali Murat
Published: December 2021

Aim: It was aimed to evaluate the level of knowledge of family medicine residents about breast cancer screening program national standards and mammography.

Methods: In this cross-sectional study, an online questionnaire was used to measure the knowledge level of family medicine resident doctors about breast cancer and mammography. In addition to demographic information, the questionnaire included questions about the diagnostic advantages of radiological breast imaging methods, the age of onset of breast cancer screening in different risk groups, and the national breast cancer screening program. The questionnaire, prepared through Google forms, was announced on social media channels used by family physicians and kept open for three months.

Results: The mean age of 151 physicians was 30.4±4.3. 61.6% of the physicians were female and 38.4% were male. Only 11.9% (n=18) of the participants had previously attended a training/course on mammography. The mean correct answer score was 4.58±1.50 for 9 questions. The test scores of the residents who received specialized training in the education and research hospital were statistically significantly higher than those who received training in the university hospital (4.77±1.86 and 3.64±1.63). The mean score of residents who received previous mammography education was significantly higher than others.

Conclusion: Awareness and knowledge levels of family medicine residents about breast cancer screening methods and programs should be increased with multidisciplinary training programs.

Keywords: mammography, breast cancer, screening, family practice
Producción de blastosporas de Simplicillium lanosoniveum en medios de cultivo líquidos
Authors: García-Nevárez Gerardo , Hidalgo-Jaminson Eduardo , Velásquez-Valle Rodolfo
Published: December 2021

Antecedentes: Los hongos del género Simplicillium son enemigos naturales de la roya del café, Hemileia vastatrix. La producción de altas concentraciones de propágulos del micoparásito es fundamental para el manejo biorracional del patógeno.
Objetivos: Evaluar la producción de blastosporas de Simplicillium lanosoniveum in vitro.
Métodos: Se evaluó la producción de blastosporas de S. lanosoniveum (SL) en cuatro medios de cultivo líquidos con diferentes fuentes de carbono y nitrógeno: medio base (MB), medio Jackson (MJ), medio Bayfolan-Soya (BS) y medio Bayfolan-Quitina (BQ), inoculados con una suspensión de SL (1x106 conidios/50 mL de medio).
Resultados y conclusiones: Los medios BQ y BS registraron la mayor producción de blastosporas 14 días después de la inoculación (BQ=1.2X108 y BS=4.8X107). Estos resultados demuestran que es factible su uso para la reproducción de S. lanosoniveum.
Bifidobacterium adolescentis Alleviates Liver Steatosis and Steatohepatitis by Increasing Fibroblast Growth Factor 21 Sensitivity
Authors: Long Xiaoxue , Liu Dan , Gao Qiongmei , Ni Jiacheng , Qian Lingling , Ni Yueqiong , Fang Qichen , Jia Weiping , Li Huating
Published: December 2021

The gut microbiota is a newly identified contributor to the development of non-alcoholic fatty liver disease (NAFLD). Previous studies of Bifidobacterium adolescentis (B. adolescentis), a species of Bifidobacterium that is common in the human intestinal tract, have demonstrated that it can alleviate liver steatosis and steatohepatitis. Fibroblast growth factor 21 (FGF21) has long been considered as a biomarker of NAFLD, and recent studies have shown the protective effect of FGF21 analogs on NAFLD. We wondered whether B. adolescentis treatment would alleviate NAFLD via the interaction with FGF21. To this end, male C57BL/6J mice on a choline-deficient high-fat diet (CDHFD) were treated with drinking water supplemented with B. adolescentis for 8 weeks, followed by the acute administration of recombinant mouse FGF21 protein (rmFGF21) to conduct the FGF21 response test. Consistent with previous studies, B. adolescentis supplementation reversed the CDHFD-induced liver steatosis and steatohepatitis. This was evaluated on the NAFLD activity score (NAS), reduced liver enzymes, and lipid accumulation. Further studies demonstrated that B. adolescentis supplementation preserved the gut barrier, reduced the gut microbiota-derived lipopolysaccharide (LPS), and inhibited the hepatic TLR4/NF-κB pathway. This was accompanied by the elevated expressions of the receptors of FGF21, fibroblast growth factor receptor 1 (FGFR1) and β-klotho (KLB), in the liver and the decreased expression of FGF21. The results of FGF21 response test showed that B. adolescentis supplementation alleviated the CDHFD-induced FGF21 resistance. In vivo experiments suggested that LPS could suppress the expression of FGF21 and KLB in a dose-dependent manner. Collectively, this study showed that B. adolescentis supplementation could alleviate NAFLD by increasing FGF21 sensitivity.
Optimal Experience in Adult Learning: Conception and Validation of the Flow in Education Scale (EduFlow-2)
Authors: Heutte Jean , Fenouillet Fabien , Martin-Krumm Charles , Gute Gary , Raes Annelies , Gute Deanne , Bachelet Rémi , Csikszentmihalyi Mihaly
Published: December 2021

While the formulation of Mihaly Csikszentmihalyi's theory of flow, including the experience dimensions, has remained stable since its introduction in 1975, its dedicated measurement tools, research methodologies, and fields of application, have evolved considerably. Among these, education stands out as one of the most active. In recent years, researchers have examined flow in the context of other theoretical constructs such as motivation. The resulting work in the field of education has led to the development of a new model for understanding flow experience in education, specifically dedicated to adult learning. As a result of both a meticulous analysis of existing models and consideration of more recent developments, a new flow scale has thus been developed. The aim of this study is therefore twofold: to validate the new flow measurement scale dedicated to the educational environment, EduFlow-2, and to test a new theoretical model. Students taking a course (N = 6,596), some on-site and others in a MOOC, participated. Several scales were administered online at the end of the participants' course during the 2017 academic year. The factor structure of EduFlow-2 was tested using Exploratory Structural Equation Modeling. Several models were tested. The model with a second-order factor best fit the data. We tested the invariance of the flow scale measure for gender and for the type of training (MOOC/on-site). We were able to show that the flow scale is invariant of the modalities of these two variables. Results revealed good psychometric qualities for the scale, making it suitable for both on-site and distance learning. The analysis also revealed significant relationships with the classic variables of motivation, self-efficacy, learning climate, and life satisfaction. Furthermore, all four dimensions of the model were found to be adequate and consistent with the underlying theoretical arguments. In the end, this new, short flow scale and the theoretical model were demonstrated to be promising for future studies in the field of education.
Evaluation of Influence Factors on the Visual Inspection Performance of Aircraft Engine Blades
Authors: Aust Jonas , Pons Dirk , Mitrovic Antonija
Published: December 2021

Background—There are various influence factors that affect visual inspection of aircraft engine blades including type of inspection, defect type, severity level, blade perspective and background colour. The effect of those factors on the inspection performance was assessed. Method—The inspection accuracy of fifty industry practitioners was measured for 137 blade images, leading to N = 6850 observations. The data were statistically analysed to identify the significant factors. Subsequent evaluation of the eye tracking data provided additional insights into the inspection process. Results—Inspection accuracies in borescope inspections were significantly lower compared to piece-part inspection at 63.8% and 82.6%, respectively. Airfoil dents (19.0%), cracks (11.0%), and blockage (8.0%) were the most difficult defects to detect, while nicks (100.0%), tears (95.5%), and tip curls (89.0%) had the highest detection rates. The classification accuracy was lowest for airfoil dents (5.3%), burns (38.4%), and tears (44.9%), while coating loss (98.1%), nicks (90.0%), and blockage (87.5%) were most accurately classified. Defects of severity level S1 (72.0%) were more difficult to detect than increased severity levels S2 (92.8%) and S3 (99.0%). Moreover, visual perspectives perpendicular to the airfoil led to better inspection rates (up to 87.5%) than edge perspectives (51.0% to 66.5%). Background colour was not a significant factor. The eye tracking results of novices showed an unstructured search path, characterised by numerous fixations, leading to longer inspection times. Experts in contrast applied a systematic search strategy with focus on the edges, and showed a better defect discrimination ability. This observation was consistent across all stimuli, thus independent of the influence factors. Conclusions—Eye tracking identified the challenges of the inspection process and errors made. A revised inspection framework was proposed based on insights gained, and support the idea of an underlying mental model.
DPDRC, a Novel Machine Learning Method about the Decision Process for Dimensionality Reduction before Clustering
Authors: Dessureault Jean-Sébastien , Massicotte Daniel
Published: December 2021

This paper examines the critical decision process of reducing the dimensionality of a dataset before applying a clustering algorithm. It is always a challenge to choose between extracting or selecting features. It is not obvious to evaluate the importance of the features since the most popular methods to do it are usually intended for a supervised learning technique process. This paper proposes a novel method called “Decision Process for Dimensionality Reduction before Clustering” (DPDRC). It chooses the best dimensionality reduction method (selection or extraction) according to the data scientist’s parameters and the profile of the data, aiming to apply a clustering process at the end. It uses a Feature Ranking Process Based on Silhouette Decomposition (FRSD) algorithm, a Principal Component Analysis (PCA) algorithm, and a K-means algorithm along with its metric, the Silhouette Index (SI). This paper presents five scenarios based on different parameters. This research also aims to discuss the impacts, advantages, and disadvantages of each choice that can be made in this unsupervised learning process.
The Use of Olkuska Sheep Milk for the Production of Symbiotic Dairy Ice Cream
Authors: Kowalczyk Magdalena , Znamirowska Agata , Pawlos Małgorzata , Buniowska Magdalena
Published: December 2021

The aim of this study was to determine the possibility of using Olkuska sheep milk for the production of ice cream with probiotics and prebiotics. The study examined the effect of the storage and type of bacteria used for the fermentation of ice cream mixes and partial replacement of inulin with apple fiber on the physicochemical properties, viability of probiotic cultures and organoleptic properties of sheep’s milk ice cream stored at −22 °C for 21 days. The addition of apple fiber reduced the pH value of ice cream mixes before fermentation. In ice cream mixes and ice cream with apple fiber, the lactic acid content was higher by 0.1–0.2 g L−1 than in their equivalents with inulin only. These differences persisted during the storage of the ice cream. After fermentation of the ice mixes, the bacterial cell count ranged from 10.62 log cfu g−1 to 12.25 log cfu g−1. The freezing process reduced the population of probiotic bacteria cells in ice cream with inulin from 0.8 log cfu g−1 in ice cream with Lactobacillus acidophilus, 1.0 log cfu g−1 in ice cream with Lacticaseibacillus paracasei and 1.1 log cfu g−1 in ice cream with Lacticaseibacilluscasei. Freezing the varieties with apple fiber also resulted in a reduction of viable bacterial cells from 0.8 log cfu g−1 in ice cream with L. paracasei and Lb. acidophilus to 1 log cfu g−1 in ice cream with L. casei, compared to the results after fermentation. The highest percentage overrun was determined in ice cream with L. paracasei and Lb. acidophilus. Ice cream with L. casei was characterized by significantly lower overrun on the 7th and 21st days of storage. Although L. paracasei ice cream had the highest overrun, it did not cause a significant reduction in the probiotic population during storage. After seven days of storage, the first drop differed significantly depending on the type of bacteria used for fermentation of the mixture and the addition of apple fiber. L. casei ice cream had a longer first drop time than L. paracasei and Lb. acidophilus ice cream. Partial replacement of inulin with apple fiber resulted in a significant darkening of the color of ice cream mixes. Depending on the type of bacteria used for fermentation, the addition of apple fiber decreased the value of the L* parameter. Ice cream mixes and ice cream with inulin and apple fiber were characterized by a high proportion of yellow. Partial replacement of inulin with apple fiber reduced the hardness of ice cream compared to inulin-only ice cream. Moreover, the panelists found that ice cream with inulin was characterized by a sweeter taste than ice cream with apple fiber. Moreover, the addition of apple fiber favorably increased the flavor and aroma perception of the mango-passion fruit. Therefore, the milk of Olkuska sheep could be successfully used for the production of symbiotic dairy ice cream.
The Sexual Effect of Chicken Embryos on the Yolk Metabolites and Liver Lipid Metabolism
Authors: Ding Peng , Tong Yueyue , Wu Shu , Yin Xin , Liu Huichao , He Xi , Song Zehe , Zhang Haihan
Published: December 2021

The metabolic processes of animals are usually affected by sex. Egg yolk is the major nutrient utilized for the growth and development of a chicken embryo. In this study, we explored the differences of yolk metabolites in male and female chicken embryos by LC–MS/MS. Furthermore, we investigated the mRNA expression of lipoprotein lipase (LPL) and fatty acid synthase (FAS) in chicken embryo liver with different sexes in different embryonic stages. The results showed that the nutrient metabolites in the yolk of female chickens were mainly related to lipid metabolism and amino acid metabolism in the early embryonic stage, and vitamin metabolism in the late embryonic stage. The male yolk metabolites were mainly associated with lipid metabolism and nucleic acid metabolism in the early developmental stage, and amino acids metabolism in the late embryonic stage. There was no significant difference in the expression of LPL or FAS in livers of male and female chicken embryos at different embryonic stages. Our results may lead to a better understanding of the sexual effect on yolk nutrient metabolism during chicken embryonic development.
Att-BiL-SL: Attention-Based Bi-LSTM and Sequential LSTM for Describing Video in the Textual Formation
Authors: Ahmed Shakil , Saif A F M Saifuddin , Hanif Md Imtiaz , Shakil Md Mostofa Nurannabi , Jaman Md Mostofa , Haque Md Mazid Ul , Shawkat Siam Bin , Hasan Jahid , Sonok Borshan Sarker , Rahman Farzad , Sabbir Hasan Muhommod
Published: December 2021

With the advancement of the technological field, day by day, people from around the world are having easier access to internet abled devices, and as a result, video data is growing rapidly. The increase of portable devices such as various action cameras, mobile cameras, motion cameras, etc., can also be considered for the faster growth of video data. Data from these multiple sources need more maintenance to process for various usages according to the needs. By considering these enormous amounts of video data, it cannot be navigated fully by the end-users. Throughout recent times, many research works have been done to generate descriptions from the images or visual scene recordings to address the mentioned issue. This description generation, also known as video captioning, is more complex than single image captioning. Various advanced neural networks have been used in various studies to perform video captioning. In this paper, we propose an attention-based Bi-LSTM and sequential LSTM (Att-BiL-SL) encoder-decoder model for describing the video in textual format. The model consists of two-layer attention-based bi-LSTM and one-layer sequential LSTM for video captioning. The model also extracts the universal and native temporal features from the video frames for smooth sentence generation from optical frames. This paper includes the word embedding with a soft attention mechanism and a beam search optimization algorithm to generate qualitative results. It is found that the architecture proposed in this paper performs better than various existing state of the art models.
Effect of Tuned Spring on Vibration Control Performance of Modified Liquid Column Ball Damper
Authors: Shah Mati Ullah , Usman Muhammad , Farooq Syed Hassan , Kim In-Ho
Published: December 2021

This paper reports the theoretical findings of the new modified type of tuned liquid column ball damper (TLCBD), called a tuned liquid column ball spring damper (TLCBSD). In this new modified form, the ball inside the horizontal section of the damper is attached to the spring. Furthermore, two types of this modified version are proposed, known as a tuned liquid column ball spring sliding damper (TLCBSSD) and a tuned liquid column ball spring rolling damper (TLCBSRD). In the former, the rotational motion of the ball attached to the spring is restricted, whereas in the latter, the ball attached to the spring can translate as well as rotate. Mathematical models and optimum design parameters are formulated for both types. The performance of these new modified damper versions is assessed numerically and subjected to harmonic, seismic, and impulse loadings. The results show that the performance of the newly proposed dampers is relatively better than traditional TLCBDs in harmonic and seismic excitations. The peak response reduction soon after the impact load becomes zero is comparatively better in TLCBSDs over TLCBDs. Overall, the newly proposed passive vibration control devices performed excellently in structure response reduction over TLCBDs.
The Efficiency of Pd Addition and Sr Substitution on La1−xSrxMnO3 to Remove Ventilation Air Methane in a Catalytic Flow Reversal Reactor
Authors: Wang Yanxia , Zhu Tao
Published: December 2021

Ventilation air methane (VAM) is the main cause of greenhouse gas emissions in coal mining. Catalytic flow reverse reactor (CFRR) is widely used in VAM to mitigate methane emissions. In this study, palladium (Pd) and La1−xSrxMnO3 were used as catalysts in a CFRR. Different types of catalysts were prepared by loading La0.8Sr0.2MnO3, La0.9Sr0.1MnO3, and 0.1%Pd-La0.9Sr0.1MnO3 on a cordierite honeycomb reactor coated with γ-Al2O3 to compare their performances. In addition, this study compared the performance of the three catalysts in an 800 °C reactor based on different methane inlet concentrations, inlet speeds, and conversion times. The results showed: (1) 0.1% addition of Pd increased methane conversion. (2) La0.8Sr0.2MnO3 had higher efficiency at lower methane inlet concentrations, whereas La0.9Sr0.1MnO3 was more efficient at higher methane concentrations. This study demonstrates that a higher Sr loading is worth implementing only when the methane concentration of VAM is lower than 0.6%. (3) To achieve a higher methane conversion efficiency, the inlet velocity of methane should also be considered.
Accurate Exponential Representations for the Ground State Wave Functions of the Collinear Two-Electron Atomic Systems
Authors: Liverts Evgeny Z. , Barnea Nir
Published: December 2021

In the framework of the study of helium-like atomic systems possessing the collinear configuration, we propose a simple method for computing compact but very accurate wave functions describing the relevant S-state. It is worth noting that the considered states include the well-known states of the electron–nucleus and electron–electron coalescences as a particular case. The simplicity and compactness imply that the considered wave functions represent linear combinations of a few single exponentials. We have calculated such model wave functions for the ground state of helium and the two-electron ions with nucleus charge 1≤Z≤5. The parameters and the accompanying characteristics of these functions are presented in tables for number of exponential from 3 to 6. The accuracy of the resulting wave functions are confirmed graphically. The specific properties of the relevant codes by Wolfram Mathematica are discussed. An example of application of the compact wave functions under consideration is reported.
Development of an SNP Assay for Marker-Assisted Selection of Soil-Borne Rhizoctonia solani AG-2-2-IIIB Resistance in Sugar Beet
Authors: Ravi Samathmika , Hassani Mahdi , Heidari Bahram , Deb Saptarathi , Orsini Elena , Li Jinquan , Richards Christopher M. , Panella Lee W. , Srinivasan Subhashini , Campagna Giovanni , Concheri Giuseppe , Squartini Andrea , Stevanato Piergiorgio
Published: December 2021

Rhizoctonia solani, causing Rhizoctonia crown and root rot, is a major risk to sugar beet (Beta vulgaris L.) cultivation. The development of resistant varieties accelerated by marker-assisted selection is a priority of breeding programs. We report the identification of a single-nucleotide polymorphism (SNP) marker linked to Rhizoctonia resistance using restriction site-associated DNA (RAD) sequencing of two geographically discrete sets of plant materials with different degrees of resistance/susceptibility to enable a wider selection of superior genotypes. The variant calling pipeline utilized SAMtools for variant calling and the resulting raw SNPs from RAD sequencing (15,988 and 22,439 SNPs) were able to explain 13.40% and 25.45% of the phenotypic variation in the two sets of material from different sources of origin, respectively. An association analysis was carried out independently on both the datasets and mutually occurring significant SNPs were filtered depending on their contribution to the phenotype using principal component analysis (PCA) biplots. To provide a ready-to-use marker for the breeding community, a systematic molecular validation of significant SNPs distributed across the genome was undertaken to combine high-resolution melting, Sanger sequencing, and rhAmp SNP genotyping. We report that RsBv1 located on Chromosome 6 (9,000,093 bp) is significantly associated with Rhizoctonia resistance (p < 0.01) and able to explain 10% of the phenotypic disease variance. The related SNP assay is thus ready for marker-assisted selection in sugar beet breeding for Rhizoctonia resistance.
Galectin-9 Triggers Neutrophil-Mediated Anticancer Immunity
Authors: Ustyanovska Avtenyuk Natasha , Choukrani Ghizlane , Ammatuna Emanuele , Niki Toshiro , Cendrowicz Ewa , Lourens Harm Jan , Huls Gerwin , Wiersma Valerie R. , Bremer Edwin
Published: December 2021

In earlier studies, galectin-9 (Gal-9) was identified as a multifaceted player in both adaptive and innate immunity. Further, Gal-9 had direct cytotoxic and tumor-selective activity towards cancer cell lines of various origins. In the current study, we identified that treatment with Gal-9 triggered pronounced membrane alterations in cancer cells. Specifically, phosphatidyl serine (PS) was rapidly externalized, and the anti-phagocytic regulator, CD47, was downregulated within minutes. In line with this, treatment of mixed neutrophil/tumor cell cultures with Gal-9 triggered trogocytosis and augmented antibody-dependent cellular phagocytosis of cancer cells. Interestingly, this pro-trogocytic effect was also due to the Gal-9-mediated activation of neutrophils with upregulation of adhesion markers and mobilization of gelatinase, secretory, and specific granules. These activation events were accompanied by a decrease in cancer cell adhesion in mixed cultures of leukocytes and cancer cells. Further, prominent cytotoxicity was detected when leukocytes were mixed with pre-adhered cancer cells, which was abrogated when neutrophils were depleted. Taken together, Gal-9 treatment potently activated neutrophil-mediated anticancer immunity, resulting in the elimination of epithelial cancer cells.
Hand-Powered Inertial Microfluidic Syringe-Tip Centrifuge
Authors: Xiang Nan , Ni Zhonghua
Published: December 2021

Conventional sample preparation techniques require bulky and expensive instruments and are not compatible with next-generation point-of-care diagnostic testing. Here, we report a manually operated syringe-tip inertial microfluidic centrifuge (named i-centrifuge) for high-flow-rate (up to 16 mL/min) cell concentration and experimentally demonstrate its working mechanism and performance. Low-cost polymer films and double-sided tape were used through a rapid nonclean-room process of laser cutting and lamination bonding to construct the key components of the i-centrifuge, which consists of a syringe-tip flow stabilizer and a four-channel paralleled inertial microfluidic concentrator. The unstable liquid flow generated by the manual syringe was regulated and stabilized with the flow stabilizer to power inertial focusing in a four-channel paralleled concentrator. Finally, we successfully used our i-centrifuge for manually operated cell concentration. This i-centrifuge offers the advantages of low device cost, simple hand-powered operation, high-flow-rate processing, and portable device volume. Therefore, it holds potential as a low-cost, portable sample preparation tool for point-of-care diagnostic testing.
Increase in Low-Frequency Oscillations in fNIRS as Cerebral Response to Auditory Stimulation with Familiar Music
Authors: Bicciato Giulio , Keller Emanuela , Wolf Martin , Brandi Giovanna , Schulthess Sven , Friedl Susanne Gabriele , Willms Jan Folkard , Narula Gagan
Published: December 2021

Recognition of typical patterns of brain response to external stimuli using near-infrared spectroscopy (fNIRS) may become a gateway to detecting covert consciousness in clinically unresponsive patients. This is the first fNIRS study on the cortical hemodynamic response to favorite music using a frequency domain approach. The aim of this study was to identify a possible marker of cognitive response in healthy subjects by investigating variations in the oscillatory signal of fNIRS in the spectral regions of low-frequency (LFO) and very-low-frequency oscillations (VLFO). The experiment consisted of two periods of exposure to preferred music, preceded and followed by a resting phase. Spectral power in the LFO region increased in all the subjects after the first exposure to music and decreased again in the subsequent resting phase. After the second music exposure, the increase in LFO spectral power was less distinct. Changes in LFO spectral power were more after first music exposure and the repetition-related habituation effect strongly suggest a cerebral origin of the fNIRS signal. Recognition of typical patterns of brain response to specific environmental stimulation is a required step for the concrete validation of a fNIRS-based diagnostic tool.
Rapid Reconstruction of 3D Structural Model Based on Interactive Graph Cuts
Authors: Han Siyu , Huo Linsheng , Wang Yize , Zhou Jing , Li Hongnan
Published: December 2021

The image-based 3D reconstruction technique has been applied in many scenarios of civil engineering, such as earthquake prevention and disaster reduction, construction monitoring, and intelligent city construction. However, the traditional technique is time-consuming, and the modeling efficiency has become a bottleneck limiting its application in emergency scenarios. In this paper, a rapid reconstruction method is proposed which combines the traditional image-based 3D reconstruction technique and an interactive graph cuts algorithm. Firstly, a sequence of images is collected around the target structure. Then, the images are preprocessed using the interactive iterative graph cuts algorithm to extract the target from each image. Finally, the resulting sequence of images is used to perform the 3D reconstruction. During the preprocessing, only a few images require manual intervention while the rest can be processed automatically. To verify the modeling accuracy of the proposed method, a column that has been destroyed is selected as a target for 3D reconstruction. The results show that compared with the traditional method, the modeling efficiency of the fast reconstruction method is doubled. In addition, the modeling accuracy is 97.65%, which is comparable to the modeling accuracy of the traditional method (97.73%); as well, by comparing the point clouds, the alignment between the two models is tremendously close, with tiny difference. The proposed rapid reconstruction method can be applied in emergency scenarios, such as rapid assessment in post-disaster situations.
Nipple Aspirate Fluid at a Glance
Authors: Patuleia Susana I. S. , Suijkerbuijk Karijn P. M. , van der Wall Elsken , van Diest Paul J. , Moelans Cathy B.
Published: December 2021

Nipple aspirate fluid (NAF) is an intraductal mammary fluid that, because of its close proximity to and origin from the tissue from which breast cancer originates, is a promising source of biomarkers for early breast cancer detection. NAF can be non-invasively acquired via the nipple by aspiration using a suction device; using oxytocin nasal spray helps increase yield and tolerability. The aspiration procedure is generally experienced as more tolerable than the currently used breast imaging techniques mammography and breast magnetic resonance imaging. Future applications of NAF-derived biomarkers include their use as a tool in the detection of breast carcinogenesis at its earliest stage (before a tumor mass can be seen by imaging), or as a supporting diagnostic tool for imaging, such as when imaging is less reliable (to rule out false positives from imaging) or when imaging is not advisable (such as during pregnancy and breastfeeding). Ongoing clinical studies using NAF samples will likely shed light on NAF’s content and clinical potential. Here, we present a narrative review and perspectives of NAF research at a glance.
The Stroma Liquid Biopsy Panel Contains a Stromal-Epithelial Gene Signature Ratio That Is Associated with the Histologic Tumor-Stroma Ratio and Predicts Survival in Colon Cancer
Authors: Ravensbergen Cor J. , Kuruc Matthew , Polack Meaghan , Crobach Stijn , Putter Hein , Gelderblom Hans , Roy Devjit , Tollenaar Rob A. E. M. , Mesker Wilma E.
Published: December 2021

Liquid biopsy has emerged as a novel approach to tumor characterization, offering advantages in sample accessibility and tissue heterogeneity. However, as mutational analysis predominates, the tumor microenvironment has largely remained unacknowledged in liquid biopsy research. The current work provides an explorative transcriptomic characterization of the Stroma Liquid BiopsyTM (SLB) proteomics panel in colon carcinoma by integrating single-cell and bulk transcriptomics data from publicly available repositories. Expression of SLB genes was significantly enriched in tumors with high histologic stromal content in comparison to tumors with low stromal content (median enrichment score 0.308 vs. 0.222, p = 0.036). In addition, we identified stromal-specific and epithelial-specific expression of the SLB genes, that was subsequently integrated into a gene signature ratio. The stromal-epithelial signature ratio was found to have prognostic significance in a discovery cohort of 359 colon adenocarcinoma patients (OS HR 2.581, 95%CI 1.567–4.251, p < 0.001) and a validation cohort of 229 patients (OS HR 2.590, 95%CI 1.659–4.043, p < 0.001). The framework described here provides transcriptomic evidence for the prognostic significance of the SLB panel constituents in colon carcinoma. Plasma protein levels of the SLB panel may reflect histologic intratumoral stromal content, a poor prognostic tumor characteristic, and hence provide valuable prognostic information in liquid biopsy.
Long-Term Outcomes of Breast Cancer Patients Who Underwent Selective Neck Dissection for Metachronous Isolated Supraclavicular Nodal Metastasis
Authors: Chen Shin-Cheh , Shen Shih-Che , Yu Chi-Chang , Huang Ting-Shuo , Lo Yung-Feng , Chang Hsien-Kun , Lin Yung-Chang , Kuo Wen-Ling , Tsai Hsiu-Pei , Chou Hsu-Huan , Lee Li-Yu , Huang Yi-Ting
Published: December 2021

We retrospectively enrolled 139 patients who developed metachronous isolated supraclavicular lymph node metastasis (miSLNM) from 8129 consecutive patients who underwent primary surgery between 1990 and 2008 at a single medical center. The median age was 47 years. The median follow-up time from date of primary tumor surgery was 73.1 months, and the median time to the date of neck relapse was 43.9 months in this study. Sixty-one (43.9%) patients underwent selective neck dissection (SND). The 5-year distant metastasis-free survival (DMFS), post-recurrence survival, and overall survival (OS) rates in the SND group were 31.1%, 40.3%, and 68.9%, respectively, whereas those of the no-SND group were 9.7%, 32.9%, and 57.7%, respectively (p = 0.001). No SND and time interval from primary tumor surgery to neck relapse ≤24 months were the only significant risk factors in the multivariate analysis of DMFS (hazard ratio (HR), 1.77; 95% confidence interval (CI), 1.23–2.56; p = 0.002 and HR, 1.76, 95% CI, 1.23–2.52; p = 0.002, respectively) and OS (HR, 1.77; 95% CI, 1.22–2.55; p = 0.003 and HR, 3.54, 95% CI, 2.44–5.16; p < 0.0001, respectively). Multimodal therapy, including neck dissection, significantly improved the DMFS and OS of miSLNM. Survival improvement after miSLNM control by intensive surgical treatment suggests that miSLNM is not distant metastasis.
Golgi Alpha1,2-Mannosidase IA Promotes Efficient Endoplasmic Reticulum-Associated Degradation of NKCC2
Authors: Demaretz Sylvie , Seaayfan Elie , Bakhos-Douaihy Dalal , Frachon Nadia , Kömhoff Martin , Laghmani Kamel
Published: December 2021

Mutations in the apically located kidney Na-K-2Cl cotransporter NKCC2 cause type I Bartter syndrome, a life-threatening kidney disorder. We previously showed that transport from the ER represents the limiting phase in NKCC2 journey to the cell surface. Yet very little is known about the ER quality control components specific to NKCC2 and its disease-causing mutants. Here, we report the identification of Golgi alpha1, 2-mannosidase IA (ManIA) as a novel binding partner of the immature form of NKCC2. ManIA interaction with NKCC2 takes place mainly at the cis-Golgi network. ManIA coexpression decreased total NKCC2 protein abundance whereas ManIA knock-down produced the opposite effect. Importantly, ManIA coexpression had a more profound effect on NKCC2 folding mutants. Cycloheximide chase assay showed that in cells overexpressing ManIA, NKCC2 stability and maturation are heavily hampered. Deleting the cytoplasmic region of ManIA attenuated its interaction with NKCC2 and inhibited its effect on the maturation of the cotransporter. ManIA-induced reductions in NKCC2 expression were offset by the proteasome inhibitor MG132. Likewise, kifunensine treatment greatly reduced ManIA effect, strongly suggesting that mannose trimming is involved in the enhanced ERAD of the cotransporter. Moreover, depriving ManIA of its catalytic domain fully abolished its effect on NKCC2. In summary, our data demonstrate the presence of a ManIA-mediated ERAD pathway in renal cells promoting retention and degradation of misfolded NKCC2 proteins. They suggest a model whereby Golgi ManIA contributes to ERAD of NKCC2, by promoting the retention, recycling, and ERAD of misfolded proteins that initially escape protein quality control surveillance within the ER.