bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical guidelines for burosumab in the treatment of XLH in children and adolescents: British paediatric and adolescent bone group recommendations
Authors: Padidela Raja , Cheung Moira S , Saraff Vrinda , Dharmaraj Poonam
Published: October 2020

X-linked hypophosphataemia (XLH) is caused by a pathogenic variant in the PHEX gene, which leads to elevated circulating FGF23. High FGF23 causes hypophosphataemia, reduced active vitamin D concentration and clinically manifests as rickets in children and osteomalacia in children and adults. Conventional therapy for XLH includes oral phosphate and active vitamin D analogues but does not specifically treat the underlying pathophysiology of elevated FGF23-induced hypophosphataemia. In addition, adherence to conventional therapy is limited by frequent daily dosing and side effects such as gastrointestinal symptoms, secondary hyperparathyroidism and nephrocalcinosis. Burosumab, a recombinant human IgG1 MAB that binds to and inhibits the activity of FGF23, is administered subcutaneously every 2 weeks. In clinical trials (phase 2 and 3) burosumab was shown to improve phosphate homeostasis that consequently resolves the skeletal/non-skeletal manifestations of XLH. Burosumab was licensed in Europe (February 2018) with the National Institute for Health and Care Excellence, UK approving use within its marketing authorisation in October 2018. In this publication, the British Paediatric and Adolescent Bone Group (BPABG) reviewed current evidence and provide expert recommendations for care pathway and management of XLH with burosumab.
Familial associations for Addison’s disease and between Addison’s disease and other autoimmune diseases
Authors: Thomsen Hauke , Li Xinjun , Sundquist Kristina , Sundquist Jan , Försti Asta , Hemminki Kari
Published: October 2020

Design

Addison’s disease (AD) is a rare autoimmune disease (AID) of the adrenal cortex, present as an isolated AD or part of autoimmune polyendocrine syndromes (APSs) 1 and 2. Although AD patients present with a number of AID co-morbidities, population-based family studies are scarce, and we aimed to carry out an unbiased study on AD and related AIDs.

Methods

We collected data on patients diagnosed with AIDs in Swedish hospitals and calculated standardized incidence ratios (SIRs) in families for concordant AD and for other AIDs, the latter as discordant relative risks.

Results

The number of AD patients was 2852, which accounted for 0.4% of all hospitalized AIDs. A total of 62 persons (3.6%) were diagnosed with familial AD. The SIR for siblings was remarkably high, reaching 909 for singleton siblings diagnosed before age 10 years. It was 32 in those diagnosed past age 29 years and the risk for twins was 323. SIR was 9.44 for offspring of affected parents. AD was associated with 11 other AIDs, including thyroid AIDs and type 1 diabetes and some rarer AIDs such as Guillain–Barre syndrome, myasthenia gravis, polymyalgia rheumatica and Sjögren’s syndrome.

Conclusions

The familial risk for AD was very high implicating genetic etiology, which for juvenile siblings may be ascribed to APS-1. The adult part of sibling risk was probably contributed by recessive polygenic inheritance. AD was associated with many common AIDs; some of these were known co-morbidities in AD patients while some other appeared to more specific for a familial setting.
Association of n-6 PUFAs with the risk of diabetic retinopathy in diabetic patients
Authors: Li Ju-shuang , Wang Tao , Zuo Jing-jing , Guo Cheng-nan , Peng Fang , Zhao Shu-zhen , Li Hui-hui , Hou Xiang-qing , Lan Yuan , Wei Ya-ping , Zheng Chao , Mao Guang-yun
Published: October 2020

Diabetic retinopathy (DR), the most common microvascular complication of diabetes and leading cause of visual impairment in adults worldwide, is suggested to be linked to abnormal lipid metabolism. The present study aims to comprehensively investigate the relationship between n-6 polyunsaturated fatty acids (PUFAs) and DR. This was a propensity score matching based case–control study, including 69 pairs of DR patients and type 2 diabetic patients without DR with mean age of 56.7 ± 9.2 years. Five n-6 PUFAs were determined by UPLC-ESI-MS/MS system. Principle component regression (PCR) and multiple conditional logistic regression models were used to investigate the association of DR risk with n-6 PUFAs depending on independent training and testing sets, respectively. According to locally weighted regression model, we observed obvious negative correlation between levels of five n-6 PUFAs (linoleic acid, γ-linolenic acid, eicosadienoic acid, dihomo-γ-linolenic acid and arachidonicacid) and DR. Based on multiple PCR model, we also observed significant negative association between the five n-6 PUFAs and DR with adjusted OR (95% CI) as 0.62 (0.43,0.87). When being evaluated depending on the testing set, the association was still existed, and PCR model had excellent classification performance, in which area under the curve (AUC) was 0.88 (95% CI: 0.78, 0.99). In addition, the model also had valid calibration with a non-significant Hosmer–Lemeshow Chi-square of 9.44 (P = 0.307) in the testing set. n-6 PUFAs were inversely associated with the presence of DR, and the principle component could be potential indicator in distinguishing DR from other T2D patients.
BioLitMine: Advanced Mining of Biomedical and Biological Literature About Human Genes and Genes from Major Model Organisms
Authors: Hu Yanhui , Chung Verena , Comjean Aram , Rodiger Jonathan , Nipun Fnu , Perrimon Norbert , Mohr Stephanie E
Published: October 2020

The accumulation of biological and biomedical literature outpaces the ability of most researchers and clinicians to stay abreast of their own immediate fields, let alone a broader range of topics. Although available search tools support identification of relevant literature, finding relevant and key publications is not always straightforward. For example, important publications might be missed in searches with an official gene name due to gene synonyms. Moreover, ambiguity of gene names can result in retrieval of a large number of irrelevant publications. To address these issues and help researchers and physicians quickly identify relevant publications, we developed BioLitMine, an advanced literature mining tool that takes advantage of the medical subject heading (MeSH) index and gene-to-publication annotations already available for PubMed literature. Using BioLitMine, a user can identify what MeSH terms are represented in the set of publications associated with a given gene of the interest, or start with a term and identify relevant publications. Users can also use the tool to find co-cited genes and a build a literature co-citation network. In addition, BioLitMine can help users build a gene list relevant to a MeSH term, such as a list of genes relevant to “stem cells” or “breast neoplasms.” Users can also start with a gene or pathway of interest and identify authors associated with that gene or pathway, a feature that makes it easier to identify experts who might serve as collaborators or reviewers. Altogether, BioLitMine extends the value of PubMed-indexed literature and its existing expert curation by providing a robust and gene-centric approach to retrieval of relevant information.
Identifying individuals in need of help for their uncontrolled gaming: A narrative review of concerns and comments regarding gaming disorder diagnostic criteria
Authors: Ko Chih-Hung , Király Orsolya , Demetrovics Zsolt , Chang Yun-Ming , Yen Ju-Yu
Published: October 2020

Objective

In 2013, the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) included the diagnostic criteria of Internet gaming disorder (IGD). Then, in 2019, the 11th Revision of the International Classification of Diseases (ICD-11) categorized gaming disorder (GD) as an addictive disorder. This review aimed to review the raised concerns, debate, and research of IGD or GD criteria and provide suggestions to resolve them.

Methods

A narrative review was conducted, and PubMed was searched for articles mentioning concerns and research on the DSM-5 criteria for IGD, ICD-11 criteria for GD, or criteria for other synonyms, such as problematic gaming or gaming addiction. A total of 107 articles were identified.

Results

Concerns were organized into three categories: conceptual framework, moral panic, and diagnostic validity. Most argumentations supported the proposition that GD and other substance use disorders have similar presentations. A clear definition of GD and adequate public education could prevent rather than exacerbate moral panic. Several researchers reported concerns regarding the nosology, diagnostic validity, and wording of each criterion. However, the threshold, five of the nine criteria with impaired function, demonstrated adequate validity in interview studies.

Conclusion

The current findings support the addiction framework, functional impairment, and validity of the GD criteria. However, further prospective, experimental, and clinical studies validating these findings are warranted. Moreover, an integrative review or debate conference could contribute to the organization of the available results and concept development. Aggregating adequate scientific information could allay or resolve concerns related to the diagnosis of GD.
More stringent criteria are needed for diagnosing internet gaming disorder: Evidence from regional brain features and whole-brain functional connectivity multivariate pattern analyses
Authors: Dong Guang-Heng , Wang Ziliang , Dong Haohao , Wang Min , Zheng Yanbin , Ye Shuer , Zhang Jialin , Potenza Marc N.
Published: October 2020

Background

Internet gaming disorder (IGD) is included in the DSM-5 as a provisional diagnosis. Whether IGD should be regarded as a disorder and, if so, how it should be defined and thresholded have generated considerable debate.

Methods

In the current study, machine learning was used, based on regional and interregional brain features. Resting-state data from 374 subjects (including 148 IGD subjects with DSM-5 scores ≥5 and 93 IGD subjects with DSM-5 scores ≥6) were collected, and multivariate pattern analysis (MVPA) was employed to classify IGD from recreational game use (RGU) subjects based on regional brain features (ReHo) and communication between brain regions (functional connectivity; FC). Permutation tests were used to assess classifier performance.

Results

The results demonstrated that when using DSM-5 scores ≥5 as the inclusion criteria for IGD subjects, MVPA could not differentiate IGD subjects from RGU, whether based on ReHo or FC features or by using different templates. MVPA could differentiate IGD subjects from RGU better than expected by chance when using DSM-5 scores ≥6 with both ReHo and FC features. The brain regions involved in the default mode network and executive control network and the cerebellum exhibited high discriminative power during classification.

Discussion

The current findings challenge the current IGD diagnostic criteria thresholding proposed in the DSM-5, suggesting that more stringent criteria may be needed for diagnosing IGD. The findings suggest that brain regions involved in the default mode network and executive control network relate importantly to the core criteria for IGD.
Influence of Different Incision Designs on Flap Extension: A Cadaveric Animal Model
Authors: Traboulsi-Garet Bassel , González-Barnadas Albert , Camps-Font Octavi , Figueiredo Rui , Valmaseda-Castellón Eduard
Published: October 2020

It is well known that wound dehiscence is one of the most frequent complications in guided bone regeneration. The main cause of this complication may be a lack of tension-free and primary wound closure. The aim of this study was to evaluate and compare the effect of periosteal releasing incisions (PRI) on the extension of 3 different flap designs: envelope, triangular, and trapezoidal. Twelve pig mandibles were used to quantify extension of the flap designs. The mandibles were equally and randomly distributed into the 3 flap groups. Each mandible was divided into 2 sides: 1 was subjected to a PRI and the other not. The flap was pulled with a force of 1.08 N, and the extension was recorded. The subgroups without PRI showed an average extension of 5.14 mm with no statistically significant differences among them (P = .165). The PRI provided an average extension of 7.37 mm with statistically significant differences among the subgroups (P < .001). The releasing incisions significantly increased flap extension in each flap design. The increase in extension of the trapezoidal flap with PRI was significantly greater than in the other subgroups. In cases where primary closure is required, surgeons should consider performing trapezoidal flaps with PRI in order to reduce tension.
Molecular approach to detecting pollen types in honey: DNA barcoding
Authors: ECEM BAYRAM Nesrin
Published: October 2020

Günümüzde, özellikle doğal ürünlere olan ilginin artmasına bağlı
olarak arı ürünlerine olan talep artmıştır. Bu ürünlerden biri olan balın
taklit edilmesi oldukça kolay olmasına rağmen taklitlerin tespit edilmesi de
bir o kadar zordur. Sahteciliği tespit etme noktasında özellikle baldaki bitki
kaynaklarını tespit etmeye yönelik çalışmalar yapılmaktadır. Balın botanik
orijinini tanımlamak için yaygın olarak kullanılan yöntemler,
melissopalinolojik analiz ve kimyasal analizlerdir. Son yıllarda ise daha hızlı,
basit ve güvenilir sonuç sunan DNA tabanlı yöntemler ile balın bitki kaynakları
tespit edilmeye başlanmasına rağmen bu konuda yapılan çalışmalar Türkiye’de yok
denecek kadar azdır. Bireysel polen tanelerinin görsel olarak incelenmesini
gerektiren morfolojik tanımlama yöntemlerinin aksine, yakın zamanda
geliştirilen genetik yaklaşımlar, polen analizlerinin ölçeğini ve çözünürlüğünü
artırma potansiyeline sahiptir. Bu çalışmada balda moleküler teknikler
kullanılarak yapılan çalışmaların sonuçları derlenerek toplu bir veri sunulması
amaçlanmış ve yöntemin avantaj ve dezavantajları değerlendirilmiştir.
Institutional Aspects of Digitalization of Regional Economy in the Context of Industry 4.0
Authors: Buyanova Marina , Averina Irina
Published: October 2020

The phenomenon of the fourth industrial revolution causes extensive changes in the economic system at all levels of its functioning. Of particular interest in this aspect are regional studies, as they allow us to consider and assess the readiness of individual subjects of the Russian Federation to these changes, as well as the degree of potential adaptation to them and opportunities for development in a new “key”, taking into account historical, geographical, social and economic prerequisites. The article includes the analysis of major constraints to economic growth at the international, national and regional levels and the full involvement of domestic economy in Industry 4.0. The differentiation in the development of meso-economic systems in Russia leads to the specificity of the approaches to adaptation of subjects to rapidly changing technological realities. The study is based on the analysis of socio-economic components of one of the regions of the Russian Federation – Volgograd region, in order to further identify the degree of its readiness for systematic development in the new neo-industrial era. The presence of a complex of problematic (similar to general) issues of a regulatory, social, financial, information and technological nature has been revealed. The identified problems require the development of directions for their solution (economic and institutional orientation) in order to reduce the level of losses in the process of transition to a new industrial model of economic development and increase the opportunities to ensure favorable competitive positions within it for the region.
Objective Grading System Scores After the Use of a New Finishing Protocol
Authors: Carvajal Flórez Álvaro , Zapata Noreña Óscar , Barbosa Liz Diana María , Plazas Patricia , Montoya Sepúlveda Felipe , Murillo Ana Milena
Published: October 2020

Objective: This non-randomized controlled clinical trial compared a new finishing protocol UDEA2 with the UDEA1 finishing protocol, according to the Objective Grading System (ogs).Methods: Forty-one patients treated in the postgraduate orthodontics clinic were included. Twenty patients served as intervention group (ig) with whom was used the UDEA2 protocol which includes dental positioners, and were compared to twenty-one patients that served as control group (cg) with whom was used the UDEA1 finishing protocol. An orthodontist (gold standard) determined the required movements with positioners used in the UDEA2 protocol. Eight ogs variables were measured by a calibrated clinician.Results: Both groups were comparable in gender, age and severity, but not in type of treatment applied. The total ogs for gc was 28.9±10.0, for ig at T1 (before the positioner) was 20.4±6.0 and the score for ig at T2 (after the positioner) was 19.2±6.0, with statistically significant differences (P≤0.05). The ogs score was principally increased for “alignment” in gc and ig-T1 groups. This variable decreased significantly in the ig-T2 group. There were no patients with more than 30 points in the ig-T2. The regression analysis showed an association (P=0.002) between the finishing protocol applied and the final ogs score. Possibility of belonging to the ig-T2 decreases as the ogs score increases (odds ratio [or] 0.83; 95% confidence interval [CI] 0.738, 0.933).Conclusions: The implementation of the UDEA2 finishing protocol, which includes an orthodontics student’s constant training, a Finishing Protocol Guide application, and a dental positioner in the finishing phase, showed an improvement in quality of orthodontic treatments.
Reflexiones sobre la situación actual de la formación de profesionales de odontología en Colombia
Authors: Martínez Delgado Cecilia María
Published: October 2020

El escenario de la formación de odontólogos en el país es preocupante, no por la calidad de lo que se enseña, sino por la manera como este recurso humano tan importante, está pasando por una época de precarización que bien podría contenerse en la medida en que el país reflexione para qué formar profesionales de la salud bucal, si no hay posibilidades de empleo, o si las hay, con un costo muy alto que no se compadece con el retorno a la inversión esperado por los egresados y por sus familias. Este artículo de reflexión quiere generar provocaciones amén de otras que ya se han planteado en el medio nacional, para que entre todos: formadores, decisores de políticas, agremiaciones, los mismos estudiantes, se haga efectiva una planeación de los recursos humanos en salud como lo han reclamado desde hace muchísimas décadas la Organización Mundial de la Salud (OMS), la Organización Panamericana de la Salud (OPS) entre otros.
The Corporate Bond Market Crises and the Government Response
Authors: Sharpe Steven A. , Zhou Xing
Published: October 2020

The Covid-19 pandemic led to acute stress in the global economy and, as a consequence, many parts of the global financial system. In the U.S., when concerns over the coronavirus escalated in March, many financial markets were hit by extraordinary selling pressure.
Estado y acción colectiva: los afiliados al Seguro Social Campesino en Ecuador, 1993-1998
Authors: Leon Ninfa de Lourdes
Published: October 2020

El estudio de las relaciones entre el Estado y la acción colectiva se ha vuelto un ámbito de interésacadémico en la última década. El presente artículo se inscribe en este campo de preocupacionescon la particularidad de que su foco de análisis es el papel del Estado en la génesis de la accióncolectiva. Teniendo como referencia a Alberto Melucci (1989), se rastrean las interacciones quese dieron, entre los afiliados al Seguro Social Campesino (SSC) y los operadores de la políticapública en la aplicación de la política de aseguramiento. Se logran identificar los procesos clave deconstrucción del momento de latencia de la acción colectiva: la modalidad de afiliación medianteuna representación corporativa y la implementación de un modelo de atención integral, integradoy participativo.
De la igualdad natural a la igualdad de oportunidades. Revisitando la teoría igualitarista frente al bienestar y la desigualdad en América Latina
Authors: Hernández Bazán Freddy
Published: October 2020

En este artículo se revisan los fundamentos teóricos y filosóficos del concepto de desigualdad como justificación a las medidas redistributivas y de atención a las asimetrías en el bienestar, en escenarios de persistente y alta desigualdad. Presenta, primero, un planteamiento analítico sobre los principales conceptos de desigualdad dentro de la teoría igualitarista contemporánea y, segundo, un análisis empírico que asocia la desigualdad y el nivel de bienestar anuales en 18 países de América Latina, de 2001 a 2013, por el tipo de régimen de bienestar. Uno de los principales resultados es que, en países con regímenes de bienestar más igualitaristas y de mayor desmercantilización, la asociación entre desigualdad y bienestar es negativa y estadísticamente significativa.
El «yo» del sujeto migrante. Análisis de «La conversión de Uei-Kuong» de Siu Kam Wen
Authors: Yuan Yushu
Published: October 2020

Como escritor peruano de origen chino, Siu Kam Wen describe en el cuento «La conversión de Uei-Kuong» la vida caótica de Uei-Kuong, un peruano que se crió en China pero vuelve a vivir en Lima. Por medio del discurso múltiple del tiempo, el espacio y los narradores, Siu construye la figura del «sujeto migrante» y habla de la confusión de la identidad étnica debido a la incongruencia del «yo» cognitivo y el «mí» social. Por medio de Uei-Kuong, Siu Kam Wen logra presentar no solo el «yo individual» que sufre crisis de identidad, sino también el «yo colectivo» del hombre inmigrante chino que vive simultáneamente en dos mundos, pero condenados a pertenecer al «no lugar».
https://doi.org/10.17398/2660-7301.41.175
Tradición e innovación temática y métrica en Las latinas o poesías castellanas en metro latino de Esteban Manuel de Villegas
Authors: Díez Coronado María Ángeles
Published: October 2020

Esteban Manuel de Villegas, oriundo de Matute, La Rioja, se presenta en el panorama literario español del siglo xvii como una rara avis. Desde su más temprana juventud, cuando comienza su producción, se provee a sí mismo de un canon literario de corte clásico en cuanto a contenidos y estructura y moldea sus composiciones poéticas con unos criterios alejados de las tendencias del momento, pensando que con el resultado superará incluso a los ya consagrados autores del Siglo de Oro español. Una de sus apuestas más arriesgadas la materializa en el libro cuarto de la segunda parte de Las Eróticas o amatorias, obra que publica en 1618.
En el artículo que sigue se contextualiza la vida literaria del autor, se describe grosso modo su obra poética y se comentan desde el punto de vista del contenido y la métrica varias composiciones de su libro titulado Las latinas con la idea de mejorar el conocimiento de un autor que, aunque no logra eclipsar, a pesar de intentarlo desde la misma portada de su trabajo, a los autores que vertebran la literatura española del Siglo de Oro; sin embargo, sí que adopta unas acertadas decisiones sobre cuestiones métricas en un momento de asentamiento de criterios compositivos en verso.
https://doi.org/10.17398/2660-7301.41.61
Tipología de arcaísmos en el DRAE en la primera mitad del siglo XIX
Authors: Jiménez Ríos Enrique
Published: October 2020

El artículo establece la tipología de arcaísmos en el Diccionario de la lengua española de la Real Academia Española en las ediciones publicadas en la primera mitad del siglo xix. El interés por el léxico arcaico desde el Diccionario de Autoridades, en particular en su segunda edición de 1770, y la atención preferente que se manifiesta en las posteriores explica que la atención se ponga en este momento. Se atiende a los procedimientos usados para su marcación y a los cambios por adición y supresión; se analizan las características de los arcaísmos, de lo que resulta que abundan las variantes formales —gráficas o morfológicas— sobre las léxicas, variación que hace que presenten remisión en vez de definición. Se considera la dificultad para establecer la fuente del léxico arcaico, aspecto de interés al comprobar que es mayor su inserción en unas ediciones que en otras y que dicha inserción afecta a un tipo concreto de voces.
https://doi.org/10.17398/2660-7301.41.95
The Reaction Path of Product Release in NO Detoxification at the Active Site of Truncated Hemoglobin N in MCSCF Approach
Authors: Simon K.V. , Tulub A.V.
Published: October 2020

The Multi-Configurational Self-Consistent Field approach with the geometry optimization was applied to the calculation of electronic properties of active site of heme core of truncated hemoglobin N, with the inclusion of [ONOO] functional group and two water molecules. The localized molecular orbitals are employed as a starting set. Two subspaces of full interaction have been used by the construction of MCSCF wavefunction. The first one includes 3d orbitals of iron atom, and the second contains bonding and antibonding molecular orbitals of peroxynitrite with one unshared electronic pair of the O2 fragment. The reaction is characterized by two transition states; the products are nitrate anion and one unbound water molecule. There arise an evidence of NO2 and NO radicals as the reaction products.
Ready for the World? Measuring the (Trans-)National Quality of Political Issue Publics on Twitter
Authors: Schünemann Wolf J.
Published: October 2020

This article presents a multi-method research design for measuring the (trans-)national quality of issue publics on Twitter. Online communication is widely perceived as having the potential to overcome nationally bound public spheres. Social media, in particular, are seen as platforms and drivers of transnational communication through which users can easily connect across borders. Transnational interactivity can be expected in particular for policy fields of global concern and elite or activist communication as practiced on Twitter. Nevertheless, there is still a lot of evidence for the enduring national structuration of political communication and publics as it results from a shared language (mostly), culturally defined media markets, established routines of social and political communication, and sociocultural stocks of knowledge. The study goes beyond measuring user interaction and also includes indicators of cross-referential cohesion. It applies a set of computational methods in network and discourse analysis and presents empirical evidence for Twitter communication on climate change being a prime issue of global concern and a globalized policy agenda. For empirical analysis, the study relies on a large Twitter dataset (N ≈ 6m tweets) with tweet messages and metadata collected between 2015 and 2018. Based on basic measurements such as geolocation and language use, the metrics allowed measurement of cross-national user interactions, user centrality in communicative networks, linking behaviour, and hashtag co-occurrences. The findings of the exploratory study suggest that a combined perspective on indicators of user interaction and cross-referential cohesion helps to develop a better and more nuanced understanding of online issue publics.
Social Media, Populism, and Migration
Authors: Datts Mario
Published: October 2020

Several scholars have attributed high hopes to social media regarding their alleged ability to enable a nonhierarchical and freely accessible debate among the citizenship (Loader & Mercea, 2011; Shirky, 2011). Those hopes have culminated in theses such those describing the social web as being a ‘new public sphere’ (Castells, 2009, p. 125) as well as in expectations regarding its revitalizing potential for the ‘Habermas’s public sphere’ (Kruse, Norris, & Flinchum, 2018, p. 62). Yet, these assumptions are not uncontested, particularly in the light of socially mediated populism (Mazzoleni & Bracciale, 2018). Interestingly, research on populism in the social web is still an exception. The same is true for the populist permeation of the social media discourse on migration, as a highly topical issue. This study seeks to elaborate on this research gap by examining to what extent the Twitter debate on the Global Compact for Safe, Orderly, and Regular Migration (GCM) was permeated by populist content. For this purpose, almost 70,000 tweets on the most important Hashtags referring to the GCM that took place in Marrakesh in December 2018 were collected and the 500 widest-reaching tweets analysed in terms of their populist permeation. Against initial expectations, the empirical findings show that populist narratives did not dominate the Twitter debate on migration. However, the empirical results indicate that ordinary citizens play an important role in the creation and dissemination of populist content. It seems that the social web widens the public sphere, including those actors who do not communicate in accordance with the Habermasian conceptualization of it.
Phenomenological Analysis of the Dynamics of Clients’ Experience in the Process of Psychotherapy: A Case-Study. Part 2
Authors: Kiselnikova N.V. , Lavrova E.V. , Almukhametova T.N. , Kuminskaya E.A. , Rzaeva F.R.
Published: October 2020

The paper reports the results of the phenomenological study of client experiences in the process of psychotherapy. It describes the stages of categorization, generalization, and interpretation of data. We raised the following questions: what changes happen to client experiences during the same treatment session and between sessions; and how these changes relate to the components of optimal experience. The sample consisted of 6 people aged 32—53, 5 women, and one man. One female client attended four meetings with a psychotherapist; the male and four female clients attended three meetings each. The transcripts were coded by two independent experts, followed by a joint discussion. First, unique semantic units were marked, then the statements were coded and categorized by experts. We give an account of the generalized dynamics of client experiences. The results of applying the categorical grid of the model of optimal experience to the dynamics of client experiences are presented separately. The yielded results can be interpreted as qualitative effectiveness markers of psychotherapeutic work.
Internet Interventions for Mental Health: Current State of Research, Lessons Learned and Future Directions
Authors: Bielinski L.L. , Berger T.
Published: October 2020

This article gives an overview of current research on internet interventions in the field of mental health. As a result of COVID-19, the implementation of internet interventions has been given a boost in the mental health sectors of several countries all over the world. With regard to these developments, a definition of internet interventions is provided and the current state of research on different formats, treatment contents, and settings of internet interventions is discussed. Current research on the therapeutic alliance in internet interventions and possible negative effects is also described. The review closes with lessons learned from the past decades of research on internet interventions along with possible implications and future directions.
Digital Technologies in Rehabilitation of Patients with Focal Brain Injury
Authors: Kalantarova M. , Zavaliy L.B. , Borisonik E.V. , Subotich M.I. , Grechko A.V. , Shchelkunova I.G. , Petrikov S.S.
Published: October 2020

Focal damage of the brain leads to cognitive impairments, which sufficiently limit the person’s functional capabilities, which, in turn, can lead to secondary disorders of the emotional and personal sphere and social maladjustment. The need to include cognitive rehabilitation in the system of complex treatment methods for patients with focal brain lesions is generally recognized. The article describes methods of neurorehabilitation based on high technologies and indicates their place in the general rehabilitation process. Data yielded by domestic and foreign studies on the effectiveness of digital technologies in the cognitive rehabilitation of patients with focal brain lesions is presented.
A Parametric Study Of Window, Orientation And Shading to Minimize Energy Consuption in Mechanically Ventilated High Rise Office Buildings in Dhaka, Bangladesh
Authors: Hossain Md Shajjad
Published: October 2020

Vital statistics of a building, meaning geometric attributes, are very important design tool to manipulate energy performance of a building which is often neglected. Though a lot of recent researches focused on increasing capabilities of material and technology to build energy efficient buildings, design elements such as form, shape, window, orientation, etc. can play a very important and effective role to increase energy efficiency. The strategic design decisions about geometric attributes in the design phase costs almost nothing and can save energy bills through lifetime of the building, which is yet be specified in particular climatic region and particular building types where energy consumption matters in national scale. This paper investigates the critical proportion of façade glazing through parametric study by simulation to obtain optimum balance between luminous and thermal behavior as well as energy consumption. The context of the study is Dhaka, with tropical monsoon climate where heat and humidity is a big concern. The experiment is carried out and hence relevant to highrise office building due to its large vertical surface compared to insignificant roof area. The outcomes indicate that significant harvesting of daylight and reduction of total energy consumption by 50% comes with proper shading on large glazing on East and West facade; and 30% on South facade.
Anogenital Warts Prevalence and Associated Risk Factors among MSM Population in Surakarta, Indonesia
Authors: Soenardi Ancella , Fiqri Ahmad , Trisnarizki Leonardo , Kariosentono Harijono , Probandari Ari Natalia , Mawardi Prasetyadi , Redhono Dhani , Ellistasari Endra Yustin
Published: October 2020

To know anogenital warts prevalence and its correlation with HIV infection in men who have sex with men (MSM) population in Surakarta, Indonesia. To identify risk factors associated with anogenital warts among MSM population in Surakarta, Indonesia.

This cross-sectional study collects data from MSM population in Surakarta, Indonesia. Patients are MSM who joined monthly mobile clinic held by the health government of Surakarta and those who attend the Voluntary Consultation and Testing Clinic of Dr. Moewardi General Hospital. Risk factors were asked using questionnaire. Physical examination was used to diagnose anogenital warts, and took blood samples for HIV screening.

From 190 subjects, 25 (13.1%) had anogenital warts, and 17 (8.9%) are HIV positive. Anogenital warts increase the odds of having HIV infection by 5.18 times. Risk factors that contribute to anogenital warts include age 25-34 years old (OR= 3,729) and a history of drug abuse (OR= 7.184).

This research only uses simple physical examination to diagnose anogenital warts, and the small study subjects may not be representative of general MSM population in Indonesia.

Age 25-34 years old and history of drug abuse are substantial risk factors for anogenital warts. Having anogenital warts infection increases the odds of acquiring HIV.  This study highlights the importance of STD screening especially in high-risk population such as MSM, which currently is still neglected by the Health Department of Indonesia.
Depósitos del Aptiano inferior con amonitas y rudistas, Punta Espada, Alta Guajira (Uribia – Colombia). Litoestratigrafía y apreciaciones regionales
Authors: Patarroyo Pedro , Götz Stephan
Published: October 2020

En depósitos del valle Piedra del Destino (Punta Espada, Uribia – La Guajira, Colombia) se presentan biomicritas, bioesparitas y lodolitas calcáreas, en las que se encontraron Dufrenoyia sp., D. cf. hansbuergli, Cheloniceras sp. Pseudohaploceras cf. liptoviense y Amphitriscoelus waringi con un rango estratigráfico del Aptiano inferior. La literatura refiere que dichos depósitos hacen parte de la Formación Cogollo, pero con base en el análisis de la litoestratigrafía, la fauna fósil, la tectónica y la continuidad de los cuerpos de roca, difícilmente se recomienda aplicar la nomenclatura litoestratigráfica del occidente de Venezuela para la Alta Guajira, región que involucra los depósitos cretácicos de Punta Espada. La fauna encontrada muestra influencia tanto del mar del Tetis como del entorno regional por provincialismo
A Calibration Technique for Bi-axial Shake Tables with Stepper Motor
Authors: DAMCI Erdem , ŞEKERCI Çağla , TAŞKIN Yener , GÜRKAN Koray
Published: October 2020

Shaking tables are frequently used to determine the dynamic behavior of structures in the laboratory environment. In order to obtain realistic results in experimental studies, table response and performance should be consistent with the desired motion. In this multidisciplinary study, an application of a new method for determining and calibrating the mechanical response of a developed bi-axial displacement controlled shake table according to the desired motion data is presented. The bi-axial shake table's electro-mechanical components consist of stepper motors, ball screw sets, linear ball bearings, and linear potentiometers positioned on both axes for displacement measurements. For the control and data acquisition (DAQ) unit of the shake table, an open-source electronic prototyping platform Arduino was used. From several experimental results, it was seen that, with the presented calibration method, harmonic and earthquake simulations could be achieved with a relative root mean square error (relative RMS error) of less than 5% for desired displacement-time histories.
Robotic Gynecologic Surgery: What it Means for Women
Authors: KURT Gönül , AKYÜZ Aygül , SEVEN Memnun , DEDE Murat , YENEN Müfit  Cemal
Published: October 2020

Objective: The aim of this study is to improve the understanding of the experiences of women undergoing gynecologic robotic surgery.
Method: A qualitative descriptive phenomenologic approach was used. We conducted phone interviews with women who had undergone a gynecological procedure via robotic surgery in a gynecology clinic of a university hospital (n=19). Semi-structured interviews were conducted with women, and data were analyzed using Colaizzi’s methods.
Results: Two major themes were identified. These two themes concerned: (1) Ambivalent Feelings on Robotic Surgery, and (2) Robotic Surgery was a Piece of Cake.
Conclusion: Because of the newness of this procedure, the women in this study indicated that they had concerns and lacked information about robotic gynecologic surgery but that their decision was influenced by the confidence they had in their physicians. The women indicated that they had confidence in the robotic technique and recovered quickly physically.
Anomalías genitales: contextualización de un campo olvidado en el diagnóstico prenatal
Authors: López Soto Álvaro
Published: October 2020

Objetivo: hacer una reflexión sobre el bajo desarrollo que hay actualmente en el campo del diagnóstico prenatal de las anomalías genitales. Materiales y métodos: a partir de la tesis de que el desarrollo del diagnóstico antenatal de las anomalías genitales es escaso, se presenta una comparación con el estado actual de otros campos del diagnóstico prenatal, así como con su contrapartida posnatal; se analizan las distintas causas que pueden haber llevado a esta situación, y se reflexiona sobre formas de mejora de la especialidad. Conclusión: en comparación con otras áreas del diagnóstico prenatal, la detección de anomalías genitales tiene un menor nivel de desarrollo en cuanto a la disponibilidad de herramientas diagnósticas, de protocolos de manejo o investigación clínica. Algunas causas probables son una impresión de baja prevalencia, una importancia limitada o las dificultades para su exploración. Una forma de reforzar este componente de la medicina fetal sería la integración del conocimiento actual, la adquisición de herramientas adecuadas, y una traslación a la medicina clínica.
Ultrasound Applied in the Reduction of Viscosity of Heavy Crude Oil
Authors: Olaya-Escobar David Roberto , Quintana-Jiménez Leonardo Augusto , González-Jiménez Edgar Emir , Olaya-Escobar Erika Sofia
Published: October 2020

Reducing the viscosity of heavy oil through upgrading techniques is crucial to maintaining the demand for oil, which is growing at an annual rate of 1.8%. The phenomenon of acoustic cavitation occurs when ultrasound is applied in the treatment of heavy crudes. This is an emerging technology that is being developed to improve the physical and chemical properties of highly viscous crudes, which facilitates handling, increases the proportion of light factions, and improves their price in the market. Taking into account that it does not yet operate on an industrial scale, a bibliographic review of the advances in acoustic cavitation technology with ultrasound for the improvement of heavy crude is justified, to contribute to the development of its industrial application by identifying new approaches and research guidelines in engineering and science. The objective of this article is to show the advance of said technology and describe the experiments carried out by various authors. For this purpose, a literature review was conducted with documents published from 1970 to 2020, which were compiled through a systematic search in academic databases. As a result of this review, some conceptual gaps and deficiencies in the phenomenological foundation were found, which explain the current difficulties to implement experimental tests and design the process at larger scales. These deficiencies limit the quality and repeatability of the results. A need was also identified to focus the efforts on a systematic experimentation that fulfills the laboratory and pilot plant phases, which are essential to take these technologies to an industrial scale.
COMMUNITY EMPOWERMENT BASED ON SOCIAL ENTREPRENEURSHIP TRAINING: TRAINING IN MANAGEMENT OF COFFEE LEATHER BROWNIES BUSINESS IN SOPPENG CITY, SOUTH SULAWESI
Authors: Amin Nur , Prakaswati Tingga Sari Novi , Khotimah Husnul , Sumarto Iin
Published: October 2020

The purpose of this study was to determine the level of success of the implementation of social entrepreneurship-based community empowerment programs in the training of business management of coffee skin brownies in Soppeng City, South Sulawesi. The population of this study was all people who participated in entrepreneurship training in the community empowerment program as many as 285 people. Data was collected using a questionnaire instrument that was processed and analyzed using quantitative descriptive analysis. The results showed that the level of success of the implementation of social entrepreneurship training-based empowerment programs in Soppeng City was highly measured by indicators: (1) increased knowledge and skills of the community in managing coffee skin into brownies, preparing business/business plans, and making simple books; (2) increasing community participation in training programs; and (3) increasing interest in the community in developing social-based creative entrepreneurship
ANALISIS PERAN SUKUK AL-INTIFA’A SEBAGAI INSTRUMEN DALAM MENGENTASKAN KEMISKINAN DI INDONESIA
Authors: Wiratama Dadang , Putra Bintang Ramadhan
Published: October 2020

Abstract

Today the capital market is one of the instruments that plays an important role in the economy of developed and developing countries. For developing countries like Indonesia, the capital market is an economic potential that is able to offer solutions to capital problems that are often faced in the context of national development. Especially when efforts to obtain additional capital through loans are felt to be increasingly unprofitable. Likewise with the Islamic capital market, although it is still new when compared to other Islamic financial instruments, the development of the Islamic capital market in Indonesia is considered quite good. One of the sharia financial instruments that is an important financing for the state budget is sukuk. At home, sukuk are growing quite rapidly although the proportion is still relatively small compared to conventional markets. This will be able to support the development of the Islamic capital market in Indonesia, especially if it is able to capture the opportunities that exist. One such opportunity is waqf assets which are widely available in various regions in Indonesia and many are still not being worked productively. Dual integration between sukuk and waqf in Al Intifa‘a Sukuk is expected to be able to create a financial instrument that can boost economic development and alternatives for poverty alleviation efforts in Indonesia.

Keyword: Sukuk, Waqf, Poverty, Islamic Capital Market

 

Abstrak

Dewasa ini pasar modal menjadi salah satu instrumen yang memainkan peranan penting dalam perekonomian negara maju maupun berkembang. Bagi negara berkembang seperti Indonesia, pasar modal merupakan potensi perekonomian yang mampu menawarkan solusi bagi permasalahan permodalan yang sering dihadapi dalam rangka pembangunan nasional. Terlebih ketika upaya perolehan tambahan modal melalui pinjaman dirasa semakin tidak menguntungkan. Demikian halnya dengan pasar modal syariah, walaupun masih baru jika dibandingkan dengan instrumen keuangan syariah yang lain, tapi perkembangan pasar modal syariah di Indonesia dinilai cukup baik, Salah satu instrumen keuangan syariah yang menjadi pembiayaan penting bagi anggaran negara adalah sukuk. Di dalam negeri sendiri, sukuk tumbuh cukup pesat walaupun proporsinya masih relatih kecil dibandingkan dengan pasar konvensional. Hal ini akan mampu menunjang perkembangan pasar modal syariah di Indonesia, apalagi jika mampu menangkap peluang yang ada. Salah satu peluang tersebut adalah aset wakaf yang banyak terdapat di berbagai wilayah di Indonesia dan masih banyak yang belum tergarap secara produktif. Dual integrasi antara sukuk dan wakaf dalam Sukuk Al Intifa‘a diaharapkan mampu menciptakan sebuah instrumen keuangan yang bisa mendongkrak pembangunan ekonomi dan seabgai alternatif dalam upaya pengentasan kemiskinan di Indonesia.

Kata kunci : Sukuk, Waqf, Kemiskinan, Pasar Modal Syariah
Model-driven support for business process families with the Common Variability Language (CVL)
Authors: Calegari Daniel , Delgado Andrea , Peña Leonel
Published: October 2020

To achieve a business objective, organizations may require variants of the same business process that depend on the context in which they are enacted. Several proposals have emerged to deal with the variability of business processes, focused on the modeling of a so-called process family. The proposals try to avoid modeling each variant separately, which implies duplication and maintenance of the common parts. Few of them also focus on automatically deriving a process variant from the definition of a process family, which is a central and complex task. One of these proposals is the Common Variability Language (CVL), which allows representing variability transparently in a host language. This article aims to explore the use of CVL together with the Business Process Model and Notation (BPMN 2.0) for modeling business process families, and the use of Model-Driven Engineering (MDE) techniques for the automatic generation of process variants. We also present a graphical tool supporting these ideas and a qualitative evaluation of the variability approach by using the VIVACE framework.