bluuebunny/crossref_metadata_2025 huggingface dataset:
Academic and Social Effects of Inclusion on Students without Disabilities: A Review of the Literature
Authors: Kart Ayse , Kart Mehmet
Published: January 2021

In many countries, educational practices are changing to inclusive education. Inclusive education is educating students with disabilities in general education classrooms with their peers without disabilities. If inclusive education is spreading, research needs to investigate the effects of inclusion not only for students with special needs but also for typically developing students. However, there is more research on the outcomes of inclusion for students with disabilities and less for students without disabilities in inclusive settings. Research shows academic and social gains for students with disabilities, but there is less clarity regarding the influence of inclusion on general education students. Therefore, the purpose of this review is to summarize and organize the literature on the academic and social outcomes of inclusion on students without disabilities. Academic effects of inclusion on students without disabilities are mixed, and the levels of schooling may have a differential impact on the achievement of students without disabilities. The literature indicates mostly positive or neutral effects of inclusion on the academic achievement of typically developing students in the lower grades, whereas neutral or negative influence is indicated for later grades. Additionally, students without disabilities have socially benefited from being in inclusive classrooms with students with disabilities. Mainly, the social effects of inclusion are reduction of fear, hostility, prejudice, and discrimination as well as increase of tolerance, acceptance, and understanding.
Fostering Students’ Workplace Communicative Competence and Collaborative Mindset through an Inquiry-Based Learning Design
Authors: Chen Rosa Huiju
Published: January 2021

This paper illustrates the efficiency of implementing an inquiry-based teaching and learning module on the development of workplace communication competence and collaborative mindset in a college-level English as a Foreign Language context. In particular, the study highlights the 5E constructivist approach as the pedagogical foundation and addresses the effects of project-based learning scenario on students’ engagement and their views in terms of “workplace habits of mind”. The 5E model includes five stages: engagement, exploration, explanation, elaboration, and evaluation. In addition, teaching strategies like academia-industry cooperative teaching, industry field trip, reflective writing, and project-based presentation were incorporated into each instructional phase to emphasize the development of students’ social, collaborative, and problem-solving skills. Both quantitative and qualitative data were collected including students’ perceived effectiveness of engagement activities, weekly reflective journal writing and focus group interviews. The results of the study indicate that the inquiry-based teaching and learning approach had a favorable effect on the development of students’ engagement and hands-on, mind-on skills such as critical thinking, collaboration, and communication.
Biomedical Image Processing and Classification
Authors: Mesin Luca
Published: January 2021

Biomedical image processing is an interdisciplinary field [...]
A Cartesian Genetic Programming Based Parallel Neuroevolutionary Model for Cloud Server’s CPU Usage Prediction
Authors: Ullah Qazi Zia , Khan Gul Muhammad , Hassan Shahzad , Iqbal Asif , Ullah Farman , Kwak Kyung Sup
Published: January 2021

Cloud computing use is exponentially increasing with the advent of industrial revolution 4.0 technologies such as the Internet of Things, artificial intelligence, and digital transformations. These technologies require cloud data centers to process massive volumes of workloads. As a result, the data centers consume gigantic amounts of electrical energy, and a large portion of data center electrical energy comes from fossil fuels. It causes greenhouse gas emissions and thus ensuing in global warming. An adaptive resource utilization mechanism of cloud data center resources is vital to get by with this huge problem. The adaptive system will estimate the resource utilization and then adjust the resources accordingly. Cloud resource utilization estimation is a two-fold challenging task. First, the cloud workloads are sundry, and second, clients’ requests are uneven. In the literature, several machine learning models have estimated cloud resources, of which artificial neural networks (ANNs) have shown better performance. Conventional ANNs have a fixed topology and allow only to train their weights either by back-propagation or neuroevolution such as a genetic algorithm. In this paper, we propose Cartesian genetic programming (CGP) neural network (CGPNN). The CGPNN enhances the performance of conventional ANN by allowing training of both its parameters and topology, and it uses a built-in sliding window. We have trained CGPNN with parallel neuroevolution that searches for global optimum through numerous directions. The resource utilization traces of the Bitbrains data center is used for validation of the proposed CGPNN and compared results with machine learning models from the literature on the same data set. The proposed method has outstripped the machine learning models from the literature and resulted in 97% prediction accuracy.
The Effects of Hole Arrangement and Density Ratio on the Heat Transfer Coefficient Augmentation of Fan-Shaped Film Cooling Holes
Authors: Kim Young Seo , Jeong Jin Young , Kwak Jae Su , Chung Heeyoon
Published: January 2021

An experimental study was performed to investigate the effects of the arrangement of fan-shaped film cooling holes and density ratio (DR) on heat transfer coefficient augmentation. Both single- and multi-row fan-shaped film cooling holes were considered. For the multi-row fan-shaped holes, the heat transfer coefficient was measured at DRs of 1 and 2, and both staggered and inline arrangements of holes were considered. For the single-row fan-shaped holes, DR = 1.0, 1.5, 2.0, and 2.5 and M = 1.0 and 2.0 conditions were tested. The mainstream velocity was 20 m/s, and the turbulence intensity and boundary layer thickness were 3.6% and 6 mm, respectively. The heat transfer coefficient was measured using the one-dimensional transient infrared thermography method. The results show that an increased heat transfer coefficient augmentation is observed between film cooling holes for the case with a smaller hole pitch and higher blowing ratio. For the given fan-shaped hole parameters, the effects of the row-to-row distance and hole arrangement are not significant. In addition, as the velocity difference between the mainstream and coolant increases, the heat transfer coefficient ratio increases.
Monitoring Carbon Stock and Land-Use Change in 5000-Year-Old Juniper Forest Stand of Ziarat, Balochistan, through a Synergistic Approach
Authors: Jallat Hamayoon , Khokhar Muhammad Fahim , Kudus Kamziah Abdul , Nazre Mohd , Saqib Najam u , Tahir Usman , Khan Waseem Razzaq
Published: January 2021

The Juniper forest reserve of Ziarat is one of the biggest Juniperus forests in the world. This study assessed the land-use changes and carbon stock of Ziarat. Different types of carbon pools were quantified in terms of storage in the study area in tons/ha i.e., above ground, soil, shrubs and litter. The Juniper species of this forest is putatively called Juniperus excelsa Beiberstein. To estimate above-ground biomass, different allometric equations were applied. Average above ground carbon stock of the forest was estimated as 8.34 ton/ha, 7.79 ton/ha and 8.4 ton/ha using each equation. Average carbon stock in soil, shrubs and litter was calculated as 24.35 ton/ha, 0.05 ton/ha and 1.52 ton/ha, respectively. Based on our results, soil carbon stock in the Juniper forest of Ziarat came out to be higher than the living biomass. Furthermore, the spatio-temporal classified maps for Ziarat showed that forest area has significantly decreased, while agricultural and barren lands increased from 1988 to 2018. This was supported by the fact that estimated carbon stock also showed a decreasing pattern between the evaluation periods of 1988 to 2018. Furthermore, the trend for land use and carbon stock was estimated post 2018 using a linear prediction model. The results corroborate the assumption that under a business as usual scenario, it is highly likely that the Juniperus forest will severely decline.
Growth Inhibitory and Selective Pressure Effects of Sodium Diacetate on the Spoilage Microbiota of Frankfurters Stored at 4 °C and 12 °C in Vacuum
Authors: Samelis John , Kakouri Athanasia
Published: January 2021

This study evaluated microbial growth in commercial frankfurters formulated with 1.8% sodium lactate (SL) singly or combined with 0.25% sodium diacetate (SDA), vacuum-packaged (VP) and stored at 4 °C and 12 °C. Standard frankfurters without SDA, containing 0.15% SL, served as controls (CN). Lactic acid bacteria (LAB) were the exclusive spoilers in all treatments at both storage temperatures. However, compared to the CN and SL treatments, SL + SDA delayed growth of LAB by an average of 5.1 and 3.1 log units, and 3.0 and 2.0 log units, respectively, after 30 and 60 days at 4 °C. On day 90, the SL + SDA frankfurters were unspoiled whereas the SL and CN frankfurters had spoiled on day 60 and day 30 to 60, respectively. At 12 °C, LAB growth was similar in all treatments after day 15, but strong defects developed in the CN and SL frankfurters only. Differential spoilage patterns were associated with a major reversal of the LAB biota from gas- and slime-producing Leuconostoc mesenteroides and Leuconostoc carnosum in the CN and SL frankfurters to Lactobacillus sakei/curvatus in the SL + SDA frankfurters. Thus, SL + SDA extends the retail shelf life of VP frankfurters by delaying total LAB growth and selecting for lactobacilli with a milder cured meat spoilage potential than leuconostocs, particularly under refrigeration.
Healing Lives in Community: The Integrated Transformative Potential Intervention Development (InTrePID) Method
Authors: Jemal Alexis
Published: January 2021

This conceptual paper introduces the Integrated Transformative Potential Intervention Development (InTrePID) Method. InTrePID is a method that social problem solvers can use to develop interventions (practices, programs, policies, culture) that translate the critical transformative potential development framework into concrete practice steps: (1) dialogue, (2) critical participatory action research initiatives, (3) skill building, and (4) critical action project implementation. The purpose of the InTrePID method is to develop each prong of the Critical Transformative Potential Development Framework: consciousness (awareness), accountability/responsibility, efficacy (ability), and action. The framework is theorized to bridge the gap between critical consciousness and critical action needed to transform and address dehumanizing realities that harm the self, relationships, and the community. In essence, InTrePID should generate a cyclical process for participants to increase awareness of individual and systemic factors that perpetuate interpersonal and community violence; take responsibility for (in)actions that perpetuate dehumanization and accountability for implementing solutions; develop efficacy in individual and collective community/cultural organizing skills; and, practice solution-oriented multi-level action. The paper highlights the work of a community-based project as an example of one way to implement the method to support community members in healing from the harm of dehumanization by addressing the violence of living in a dehumanizing society.
Detecting and Mapping Gas Emission Craters on the Yamal and Gydan Peninsulas, Western Siberia
Authors: Zolkos Scott , Fiske Greg , Windholz Tiffany , Duran Gabriel , Yang Zhiqiang , Olenchenko Vladimir , Faguet Alexey , Natali Susan M.
Published: January 2021

Rapid climate warming at northern high latitudes is driving geomorphic changes across the permafrost zone. In the Yamal and Gydan peninsulas in western Siberia, subterranean accumulation of methane beneath or within ice-rich permafrost can create mounds at the land surface. Once over-pressurized by methane, these mounds can explode and eject frozen ground, forming a gas emission crater (GEC). While GECs pose a hazard to human populations and infrastructure, only a small number have been identified in the Yamal and Gydan peninsulas, where the regional distribution and frequency of GECs and other types of land surface change are relatively unconstrained. To understand the distribution of landscape change within 327,000 km2 of the Yamal-Gydan region, we developed a semi-automated multivariate change detection algorithm using satellite-derived surface reflectance, elevation, and water extent in the Google Earth Engine cloud computing platform. We found that 5% of the landscape changed from 1984 to 2017. The algorithm detected all seven GECs reported in the scientific literature and three new GEC-like features, and further revealed that retrogressive thaw slumps were more abundant than GECs. Our methodology can be refined to detect and better understand diverse types of land surface change and potentially mitigate risks across the northern permafrost zone.
Effect of Exercise Training on Body Temperature in the Elderly: A Retrospective Cohort Study
Authors: Matsumura Koichiro , Iwasaka Toshiji , Mizuno Satoshi , Mizuno Ikuko , Hayanami Hikaru , Sawada Kiyoshi , Iwasaka Junji , Takeuchi Kotaro , Suga Toshimitsu , Sugiura Tetsuro , Shiojima Ichiro
Published: January 2021

Background: This study evaluated the effect of exercise training on body temperature and clarified the relationship between body temperature and body composition in the elderly. Methods: In this retrospective cohort study, a total of 91 elderly participants performed aerobic and anaerobic exercise training twice a week for 2 years. Non-contact infrared thermometer and bioelectrical impedance analysis were performed at baseline and at 2 years. Results: Mean age of study participants was 81.0 years. The participants were divided into two groups by baseline body temperature of 36.3 °C; lower body temperature group (n = 67) and normal body temperature group (n = 24). Body temperature rose significantly after exercise training in the lower body temperature group (36.04 ± 0.11 °C to 36.30 ± 0.13 °C, p < 0.0001), whereas there was no significant difference in the normal body temperature group (36.35 ± 0.07 °C to 36.36 ± 0.13 °C, p = 0.39). A positive correlation was observed between the amount of change in body temperature and baseline body temperature (r = −0.68, p < 0.0001). Increase in skeletal muscle mass was an independent variable related to the rise in body temperature by the multivariate logistic regression analysis (odds ratio: 4.77, 95% confidence interval: 1.29–17.70, p = 0.02). Conclusions: Exercise training raised body temperature in the elderly, especially those with lower baseline body temperature.
The Association between Dietary Variety and Physical Frailty in Community-Dwelling Older Adults
Authors: Kiuchi Yuto , Makizako Hyuma , Nakai Yuki , Tomioka Kazutoshi , Taniguchi Yoshiaki , Kimura Mika , Kanouchi Hiroaki , Takenaka Toshihiro , Kubozono Takuro , Ohishi Mitsuru
Published: January 2021

The aim of this cross-sectional study was to examine the association between diet variety and physical frailty in community-dwelling older adults. Data of 577 older adults (mean age: 74.0 ± 6.3 years, women: 62.5%) were analyzed. Diet variety was assessed using the Food Frequency Score (FFS) (maximum, 30 points). The FFS assessed the one-week consumption frequency of ten foods (meat, fish/shellfish, eggs, milk & dairy products, soybean products, green & yellow vegetables, potatoes, fruits, seafood, and fats & oil). Physical frailty was assessed using Fried’s component (slowness, weakness, exhaustion, low physical activity, and weight loss). The participants were classified into frail, pre-frail, and non-frail groups. The prevalence of physical frailty was 6.6%. This study found significant associations between physical frailty and low FFS after adjusting for covariates (odds ratio (OR) 0.90, 95% confidence interval (CI) 0.84–0.97, p < 0.01). The optimal cutoff point of the FFS for physical frailty was ≤16 points. FFS lower than the cutoff point were significantly associated with physical frailty after adjusting for covariates (OR 3.46, 95% CI 1.60–7.50, p < 0.01). Diet variety assessed using the FFS cutoff value of ≤16 points was related to the physical frailty status in community-dwelling older adults.
Diode Laser Management of Primary Extranasopharyngeal Angiofibroma Presenting as Maxillary Epulis: Report of a Case and Literature Review
Authors: Capodiferro Saverio , Limongelli Luisa , D’Agostino Silvia , Tempesta Angela , Dolci Marco , Maiorano Eugenio , Favia Gianfranco
Published: January 2021

Juvenile nasopharyngeal angiofibroma is a rare vascular neoplasm, mostly occurring in adolescent males, and representing 0.05% of all head and neck tumors. Nevertheless, it is usually recognized as the most common benign mesenchymal neoplasm of the nasopharynx. Usually, it originates from the posterolateral wall of the nasopharynx and, although histologically benign, classically shows a locally aggressive behavior with bone destruction as well as spreading through natural foramina and/or fissures to the nasopharynx, nasal and paranasal cavities, spheno-palatine foramen, infratemporal fossa and, very rarely, to the cranial cavity. Extranasopharyngeal angiofibroma is considered a distinct entity due to older age at presentation, different localizations (outside the nasopharyngeal pterygopalatine fossa) and attenuated clinical course. Extranasopharyngeal angiofibroma has been sporadically described in the oral cavity. We report a case of extranasopharyngeal angiofibroma with primary and exclusive involvement of the adherent gingiva of the anterior maxilla, managed by preoperative diode laser trans-mucosal photocoagulation and subsequent surgical removal. The current literature on primary extranasopharyngeal angiofibroma is also reviewed.
Portal Dissemination of Fusarium graminearum in a Patient with Acute Lymphoblastic Leukemia and Febrile Neutropenia
Authors: Uscamayta Mary Gabriela , Martin-Onraet Alexandra , Espinosa-Bautista Karla , Herrera-Goepfert Roberto , Hernández-Castro Rigoberto , Perez-Jimenez Carolina
Published: January 2021

We present the case of a man with acute lymphoblastic leukemia and prolonged profound neutropenia, who developed an invasive infection by Fusarium graminearum, acquired via non-cutaneous entry, with gastrointestinal symptoms, sigmoid perforation and liver abscesses due to portal dissemination. The etiologic agent was identified using the 18S-ITS1-5.8S-ITS2-28S rRNA sequence gene, from a liver biopsy. The infection was resolved with surgical drainage and antifungal treatment based on voriconazole. As far as we know, there are no previous reports in the literature of cases of human infection due to Fusarium graminearum.
Prevalence of Clostridioides difficile Infection in Critically Ill Patients with Extreme Leukocytosis and Diarrhea
Authors: Teja Bijan , Alibhai Nafeesa , Rubenfeld Gordon D. , Taggart Linda R. , Jivraj Naheed , Hirji Sameer A. , O’Gara Brian P. , Shaefi Shahzad
Published: January 2021

While early empiric antibiotic therapy is beneficial for patients presenting with sepsis, the presentation of sepsis from Clostridioides difficile (formerly Clostridium difficile) infection (CDI) has not been well studied in large cohorts. We sought to determine whether the combination of extreme leukocytosis and diarrhea was strongly predictive of CDI in a cohort of 8659 patients admitted to the intensive care unit. We found that CDI was present in 15.0% (95% CI, 12.1–18.3%) of patients with extreme leukocytosis and diarrhea and that mortality for those with CDI, diarrhea, and extreme leukocytosis was 33.8% (95% CI, 23.2–44.3%). These data support consideration of empiric treatment for CDI in unstable critically ill patients with extreme leukocytosis and diarrhea, along with treatment of other possible sources of sepsis as appropriate. Empiric treatment for CDI can usually be discontinued promptly, along with narrowing of other broad-spectrum antimicrobial coverage, if a sensitive C. difficile test is negative.
Angioedema and COVID-19: A New Dermatological Manifestation?
Authors: Royer Pierre-Yves , Zayet Souheil , Jacquin-Porretaz Claire , Kadiane-Oussou N’dri Juliette , Toko Lynda , Gendrin Vincent , Klopfenstein Timothée
Published: January 2021

The main localization of SARS-CoV-2 infection is the respiratory tract. Digestive and otorhinolaryngological localizations are also reported. More recently, dermatological manifestations have been reported during Coronavirus disease-19 (COVID-19). We report a case of a labial angioedema in a patient with confirmed COVID-19.
Primary Peritonitis Secondary to Streptococcus pyogenes in a Young Female Adult—A Case Report and Literature Review
Authors: Aw Avelyn E. Y. , Lee James W. K. , Tay Kon Voi
Published: January 2021

Primary spontaneous bacterial peritonitis (SBP) is a rare cause of acute abdomen in previously healthy patients, even more unusually caused by a group A Streptococcus (GAS) (also known as Streptococcus pyogenes) infection. We report a young, otherwise healthy female who presented with generalized abdominal pain that was initially managed conservatively as gastroenteritis, with a computed tomography (CT) scan showing a ruptured corpus luteal cyst. Upon subsequent readmission with worsened pain and symptoms, a repeat CT scan showed worsened free fluid with signs of peritonitis. A diagnostic laparoscopy confirmed primary peritonitis with an unknown infection source and causative pathology, as the appendix, ovaries and bowels were healthy-looking. Fluid cultures returned positive for GAS Pyogenes, while blood and urine cultures were negative. The discussion reviews the challenges in diagnosis and treatment of GAS primary peritonitis, highlighting the need for clinical suspicion, early diagnosis via laparoscopy or laparotomy and prompt antibiotic therapy as the current standard for treatment.
Application of Artificial Intelligence-Based Technologies in the Healthcare Industry: Opportunities and Challenges
Authors: Lee DonHee , Yoon Seong No
Published: January 2021

This study examines the current state of artificial intelligence (AI)-based technology applications and their impact on the healthcare industry. In addition to a thorough review of the literature, this study analyzed several real-world examples of AI applications in healthcare. The results indicate that major hospitals are, at present, using AI-enabled systems to augment medical staff in patient diagnosis and treatment activities for a wide range of diseases. In addition, AI systems are making an impact on improving the efficiency of nursing and managerial activities of hospitals. While AI is being embraced positively by healthcare providers, its applications provide both the utopian perspective (new opportunities) and the dystopian view (challenges to overcome). We discuss the details of those opportunities and challenges to provide a balanced view of the value of AI applications in healthcare. It is clear that rapid advances of AI and related technologies will help care providers create new value for their patients and improve the efficiency of their operational processes. Nevertheless, effective applications of AI will require effective planning and strategies to transform the entire care service and operations to reap the benefits of what technologies offer.
Implementation of Brain Breaks® in the Classroom and Its Effects on Attitudes towards Physical Activity in a Chinese School Setting
Authors: Zhou Ke , He Sensen , Zhou Yanli , Popeska Biljana , Kuan Garry , Chen Li , Chin Ming-Kai , Mok Magdalena Mo Ching , Edginton Christopher R. , Culpan Ian , Durstine J. Larry
Published: January 2021

This study aimed to examine the effects of three-months of classroom-based Brain Breaks Physical Activity Solution (Brain Breaks®) on attitudes toward physical activity levels of primary school children in Henan Province, China. The participants were 704 children enrolled in grades 3–5 who were randomly assigned to either an experimental or a control group. The experimental group participated in Brain Breaks® video intervention for 3–5 min daily, at low-to-moderate intensity for three consecutive months. The control group resumed their normal routine. The children’s attitudes in both groups towards physical activity (PA) were evaluated using the self-reported Attitudes toward Physical Activity Scale (APAS), before and after the intervention. The effects of the intervention on APAS scores were analyzed using mixed model analysis of variance with Time as within-subject, and Group as between-subject factors. The analysis revealed evidence in support of the positive effect of classroom video interventions such as Brain Break on children’s attitudes toward importance, fun, and trying to do their personal best in physical activity. Also revealed was the important role the teacher plays in this process.
Scientometric Analysis of Safety Sign Research: 1990–2019
Authors: Gao Jingqi , Wu Xiang , Luo Xiaowei , Guan Shukai
Published: January 2021

The purpose of this paper is to summarize the research themes and hotspots of safety signs research between 1990 and 2019 through the scientometric analysis method. In total, 3102 articles of literature from the Web of Science core database were analyzed by the CiteSpace visualization tool and the results were displayed in mapping knowledge domains. The overall characteristics analysis showed that safety sign is an emerging research field in a rapid development stage—81.4% of the literature works were published in the past ten years, and the United States was in the leading position, followed by China and Canada. The keyword co-occurrence analysis indicated that traffic signs and driving safety were the most popular research topics and have been combined with simulation technology in recent years, whereby individual mental health has been added as an influential factor. The journals and category co-citation analysis showed that the safety signs research involved many subjects, mainly engineering, transportation and public safety. The results indicated that the safety signs research is multi-disciplinary, and it will continue to develop in various scientific domains in the future. The conclusions can provide help and reference for potential readers, as well as help with the sustainable development of safety signs research.
Influence of Physical Activity on the Regulation of Disease of Elderly Persons with Metabolic Syndrome
Authors: Stetic Lucija , Belcic Ivan , Sporis Goran , Stetic Leon , Starcevic Nikola
Published: January 2021

Metabolic syndrome is a group of metabolic risk factors whose combination significantly contributes to the development of the risk of cardiovascular disease, diabetes, stroke, some cancers and is a clear indicator of morbidity rate. The aim of this study was to identify physical activity programs that can successfully influence the reduction of risk factors in metabolic syndrome of the elderly. Subjects were aged between 60 and 80 years, had three of five signs of metabolic syndrome, and were randomly divided into three groups of 20 subjects. The first group conducted a continuous cycling ergometer (55% VO2max), the second group a physical activity strength program and the third was a control group. Before and after the experimental treatment body composition, biochemical parameters, functional parameters, cardiovascular functions, metabolic and hematological system were determined. Significant differences between control and experimental groups were determined using MANOVA. The training effects of the experimental and control groups were determined using the ANOVA for repeated measurements with Bonfferoni correction. The results showed that a physical activity program of strength has a better effect on disease regulation in the elderly with metabolic syndrome than a moderate-intensity physical activity program which also has a significant change but in less variables.
The Impact of ABO Blood Grouping on COVID-19 Vulnerability and Seriousness: A Retrospective Cross-Sectional Controlled Study among the Arab Community
Authors: El-Shitany Nagla A. , El-Hamamsy Manal , Alahmadi Ahlam A. , Eid Basma G. , Neamatallah Thikryat , Almukadi Haifa S. , Arab Rana A. , Faddladdeen Khadija A. , Al-Sulami Khayria A. , Bahshwan Safia M. , Ali Soad S. , Harakeh Steve , Badr-Eldin Shaimaa M.
Published: January 2021

Background and Objectives: Studies have noted that some ABO blood types are more susceptible to COVID-19 virus infection. This study aimed to further confirm the relationship between different blood groups on the vulnerability, symptoms, cure period, and severity among COVID-19 recovered patients. Subjects and Methods: This cross-sectional study approached the participants from the Arab community via social media (mainly Facebook and WhatsApp). The data were collected through two Google Form questionnaires, one for COVID-19 recovered patients (COVID-19 group, n = 726), and the other for the healthy people (Control group, n = 707). Results: The subjects with blood group O were the least likely to be infected with the COVID-19 virus, while those with blood group A were not likely to be the most susceptible. There were significant differences among different ABO blood groups regarding the distribution of oxygen saturation percentage, myalgia, and recovery time after COVID-19 infection (p < 0.01, 0.01, and 0.05, respectively). The blood group A showed the highest percentage of patients who experienced an oxygen saturation range of 90–100%, whereas the blood group O showed the highest percentage of patients who experienced an oxygen saturation range of 70–80%. The blood group A showed the lowest percentage of patients who required artificial respiration, whereas the blood group O showed the highest percentage of patients who required artificial respiration. The blood group B showed the lowest percentage of patients who experienced myalgia and exhibited the lowest percentage of patients who needed 3 weeks or more to recover. Conclusion: The people of blood group O may be the least likely to be infected with COVID-19, however, they may be the more in need of treatment in hospital and artificial respiration compared to the other blood groups.
A Minimally-Invasive, Simple, Rapid, and Effective Surgical Technique for the Treatment of Ingrown Toenails: A Reminder of the Original Winograd Procedure
Authors: Kim Jahyung , Lee Sanghyeon , Lee Jeong Seok , Won Sung Hun , Chun Dong Il , Yi Young , Cho Jaeho
Published: January 2021

(1) Background: Ingrown toenail is a common disorder of the toe that induces severe toe pain and limits daily activities. The Winograd method, the most widely used operative modality for ingrown toenails, has been modified over years to include wedge resection of the nail fold and complete ablation of the germinal matrix. We evaluated the outcomes of original Winograd procedure without wedge resection with electrocautery-aided matrixectomy. (2) Methods: We retrospectively analyzed the outcomes of patients who underwent surgery for ingrown toenails at a university hospital for two years from November 2015 to October 2017. Surgery was performed in 76 feet with a mean operation time of 9.34 min. (3) Results: The minimal interval from surgery to return to regular activities was 13.26 (range 7 to 22) days. Recurrence and postoperative wound infections were found in 3 (3.95%) and 2 (2.63%) patients, respectively. Evaluation of patient satisfaction at one-year follow-up showed that 40 (52.63%) patients were very satisfied, 33 (43.42%) were satisfied, 3 (3.95%) were dissatisfied, and none of them were very dissatisfied. The average follow-up duration was 14.66 (range 12 to 25) months. (4) Conclusions: Therefore, it is believed that this less-invasive and simple procedure could be easily performed by clinicians, with satisfactory patient outcomes.
The ASHA (Hope) Project: Testing an Integrated Depression Treatment and Economic Strengthening Intervention in Rural Bangladesh: A Pilot Randomized Controlled Trial
Authors: Karasz Alison , Anne Shabnam , Hamadani Jena Derakhshani , Tofail Fahmida
Published: January 2021

Depression, a debilitating disorder, is highly prevalent among low-income women in low- and middle-income countries. Standard psychotherapeutic approaches may be helpful, but low treatment uptake, low retention, and transient treatment effects reduce the benefit of therapy. This pilot randomized controlled trial examined the effectiveness and feasibility of an integrated depression treatment/economic strengthening intervention. The study took place in two villages in the Sirajganj district in rural Bangladesh. Forty-eight low-income women with depressive symptoms (Patient Health Questionnaire (PHQ-9) score ≥ 10) were recruited and randomized to intervention or control arms. The intervention included a six-month group-based, fortnightly depression management and financial literacy intervention, which was followed by a cash-transfer of $186 (equivalent to the cost of two goats) at 12 months’ follow-up. The cash transfer could be used to purchase a productive asset (e.g., agricultural animals). The control arm received no intervention. Findings showed significant reduction in depression scores in the intervention group. The mean PHQ-9 score decreased from 14.5 to 5.5 (B ± SE, −9.2 ± 0.8 95% CI −10.9, −7.5, p < 0.01) compared to no change in the control group. Most other psycho-social outcomes, including tension, self-esteem, hope, social-support, and participation in household economic decision-making, also improved with intervention. An integrated depression treatment and financial empowerment intervention was found to be highly effective among rural low-income women with depression. Next steps involve formal testing of the model in a larger trial.
Evaluating the Effects of Holidays on Road Crash Injuries in the United Kingdom
Authors: Wiratama Bayu Satria , Chen Ping-Ling , Chen Liang-Hao , Saleh Wafaa , Chen Shang-Ku , Chen Hui-Tsai , Lin Hui-An , Pai Chih-Wei
Published: January 2021

Background: Research suggests that drivers tend to engage in risk-taking behaviours on public holidays. Studies that examined the association between holidays (or other special days) and fatal injuries are inconsistent. This study used UK STATS19 data to investigate the associations of nine public holidays on road crash casualties. Methods: This retrospective study assessed UK STATS19 crash data for 1990–2017. All casualties from two vehicle crashes were initially considered; subsequently, casualties with missing data were excluded. Multiple logistic regression was estimated to explore the associations of potential risk factors with the likelihood of killed or seriously injured (KSI) casualties and to calculate adjusted odds ratios (AORs). Results: In total, 3,751,998 casualties from traffic accidents in the United Kingdom during 1990–2017 were included in the final data set; among these, 410,299 (10.9%) were KSI casualties, and 3,341,699 (89.1%) were slight injuries. Crashes on public holidays were 16% (AOR = 1.16; 95% confidence interval [CI] = 1.13–1.19) more likely to involve KSI casualties than were crashes on non-holidays. With other factors controlled for, crashes during the Queen’s 2002 Golden Jubilee and on New Year’s Day were 48% (AOR = 1.48; 95% CI = 1.06–2.07) and 36% (AOR = 1.36; 1.26–1.48) more likely to lead to KSIs, respectively. Conclusions: The proportion of crashes resulting in KSI casualties on public holidays was higher than that on non-holidays. Furthermore, crashes during the Queen’s 2002 Golden Jubilee had the highest risk of KSI casualties followed by New Year’s Day.
COVID-19: Detecting Government Pandemic Measures and Public Concerns from Twitter Arabic Data Using Distributed Machine Learning
Authors: Alomari Ebtesam , Katib Iyad , Albeshri Aiiad , Mehmood Rashid
Published: January 2021

Today’s societies are connected to a level that has never been seen before. The COVID-19 pandemic has exposed the vulnerabilities of such an unprecedently connected world. As of 19 November 2020, over 56 million people have been infected with nearly 1.35 million deaths, and the numbers are growing. The state-of-the-art social media analytics for COVID-19-related studies to understand the various phenomena happening in our environment are limited and require many more studies. This paper proposes a software tool comprising a collection of unsupervised Latent Dirichlet Allocation (LDA) machine learning and other methods for the analysis of Twitter data in Arabic with the aim to detect government pandemic measures and public concerns during the COVID-19 pandemic. The tool is described in detail, including its architecture, five software components, and algorithms. Using the tool, we collect a dataset comprising 14 million tweets from the Kingdom of Saudi Arabia (KSA) for the period 1 February 2020 to 1 June 2020. We detect 15 government pandemic measures and public concerns and six macro-concerns (economic sustainability, social sustainability, etc.), and formulate their information-structural, temporal, and spatio-temporal relationships. For example, we are able to detect the timewise progression of events from the public discussions on COVID-19 cases in mid-March to the first curfew on 22 March, financial loan incentives on 22 March, the increased quarantine discussions during March–April, the discussions on the reduced mobility levels from 24 March onwards, the blood donation shortfall late March onwards, the government’s 9 billion SAR (Saudi Riyal) salary incentives on 3 April, lifting the ban on five daily prayers in mosques on 26 May, and finally the return to normal government measures on 29 May 2020. These findings show the effectiveness of the Twitter media in detecting important events, government measures, public concerns, and other information in both time and space with no earlier knowledge about them.
The Paradox Effect of Calcification in Carotid Atherosclerosis: Microcalcification Is Correlated with Plaque Instability
Authors: Montanaro Manuela , Scimeca Manuel , Anemona Lucia , Servadei Francesca , Giacobbi Erica , Bonfiglio Rita , Bonanno Elena , Urbano Nicoletta , Ippoliti Arnaldo , Santeusanio Giuseppe , Schillaci Orazio , Mauriello Alessandro
Published: January 2021

Background: this study aims to investigate the possible association among the histopathologic features of carotid plaque instability, the presence of micro- or macrocalcifications, the expression of in situ inflammatory biomarkers, and the occurrence of the major risk factors in this process in a large series of carotid plaques. Methods: a total of 687 carotid plaques from symptomatic and asymptomatic patients were collected. Histological evaluation was performed to classify the calcium deposits in micro or macrocalcifications according to their morphological features (location and size). Immunohistochemistry was performed to study the expression of the main inflammatory biomarkers. Results: results here reported demonstrated that calcifications are very frequent in carotid plaques, with a significant difference between the presence of micro- and macrocalcifications. Specifically, microcalcifications were significantly associated to high inflamed unstable plaques. Paradoxically, macrocalcifications seem to stabilize the plaque and are associated to a M2 macrophage polarization instead. Discussion: the characterization of mechanisms involved in the formation of carotid calcifications can lay the foundation for developing new strategies for the management of patients affected by carotid atherosclerosis. Data of this study could provide key elements for an exhaustive evaluation of carotid plaque calcifications allowing to establish the risk of associated clinical events.
Functional Comparison between VP64-dCas9-VP64 and dCas9-VP192 CRISPR Activators in Human Embryonic Kidney Cells
Authors: Javaid Nasir , Pham Thuong L. H. , Choi Sangdun
Published: January 2021

Reversal in the transcriptional status of desired genes has been exploited for multiple research, therapeutic, and biotechnological purposes. CRISPR/dCas9-based activators can activate transcriptionally silenced genes after being guided by gene-specific gRNA(s). Here, we performed a functional comparison between two such activators, VP64-dCas9-VP64 and dCas9-VP192, in human embryonic kidney cells by the concomitant targeting of POU5F1 and SOX2. We found 22- and 6-fold upregulations in the mRNA level of POU5F1 by dCas9-VP192 and VP64-dCas9-VP64, respectively. Likewise, SOX2 was up-regulated 4- and 2-fold using dCas9-VP192 and VP64dCas9VP64, respectively. For the POU5F1 protein level, we observed 3.7- and 2.2-fold increases with dCas9-VP192 and VP64-dCas9-VP64, respectively. Similarly, the SOX2 expression was 2.4- and 2-fold higher with dCas9-VP192 and VP64-dCas9-VP64, respectively. We also confirmed that activation only happened upon co-transfecting an activator plasmid with multiplex gRNA plasmid with a high specificity to the reference genes. Our data revealed that dCas9-VP192 is more efficient than VP64-dCas9-VP64 for activating reference genes.
Melanin-Like Nanomedicine in Photothermal Therapy Applications
Authors: Yue Yale , Zhao Xiao
Published: January 2021

Photothermal therapy (PTT) mediated by nanomaterial has become an attractive tumor treatment method due to its obvious advantages. Among various nanomaterials, melanin-like nanoparticles with nature biocompatibility and photothermal conversion properties have attracted more and more attention. Melanin is a natural biological macromolecule widely distributed in the body and displays many fascinating physicochemical properties such as excellent biocompatibility and prominent photothermal conversion ability. Due to the similar properties, Melanin-like nanoparticles have been extensively studied and become promising candidates for clinical application. In this review, we give a comprehensive introduction to the recent advancements of melanin-like nanoparticles in the field of photothermal therapy in the past decade. In this review, the synthesis pathway, internal mechanism and basic physical and chemical properties of melanin-like nanomaterials are systematically classified and evaluated. It also summarizes the application of melanin-like nanoparticles in bioimaging and tumor photothermal therapy (PTT)in detail and discussed the challenges they faced in clinical translation rationally. Overall, melanin-like nanoparticles still have significant room for development in the field of biomedicine and are expected to applied in clinical PTT in the future.
Effect of Lintel Beam on Seismic Response of Reinforced Concrete Buildings with Semi-Interlocked and Unreinforced Brick Masonry Infills
Authors: Shendkar Mangeshkumar R. , Kontoni Denise-Penelope N. , Mandal Sasankasekhar , Maiti Pabitra Ranjan , Gautam Dipendra
Published: January 2021

The primary focus of this study is to evaluate the nonlinear response of reinforced concrete (RC) frames with two types of brick infills viz., unreinforced brick masonry infill (URM) and semi-interlocked brick masonry infill (SIM) together with lintel beams, subjected to seismic loads. The seismic response is quantified in terms of response reduction factor and base shear. Infill walls are modeled using double strut nonlinear cyclic element. Nonlinear static adaptive pushover analysis is performed in the finite element program SeismoStruct. The response reduction factor (R) is computed from adaptive pushover analysis and performance for all models is obtained. The results showed that the average R factor of the RC framed structure with semi-interlocked masonry (SIM) is 1.31 times higher than the RC frame with unreinforced masonry (URM) infill. The R value of the bare frame with the lintel beam is found to be less than the corresponding value recommended in the Indian Standard Code. The results obtained in this study highlight that if the impacts of lintel beams and various brick infill scenarios are considered in the RC frames then the R values used for the design of RC frame buildings with infills would be underestimated (i.e., the evaluated R values are greater than the R values used for the design purpose).
The Relationship between Genus/Species Richness and Morphological Diversity among Subfamilies of Jewel Beetles
Authors: Tong Yi-Jie , Yang Hai-Dong , Jenkins Shaw Josh , Yang Xing-Ke , Bai Ming
Published: January 2021

A positive correlation between the species richness and morphological diversity of some organisms has been found in almost all studies at the local community scale. However, this documented relationship has not always been consistent because of diverse niches and the status of an organism in an ecosystem. Global taxon sampling, new morphological approaches, and consideration of more taxonomic categories other than species level are possible methods to further investigate this contradiction. In this study, we proposed a new paradigm for higher taxa biodiversity analysis based on a cosmopolitan dataset. A total of 1106 species from around the world representing all subfamilies and 33% genera of Buprestidae (jewel beetles) were selected to test the correlation between morphological diversity (MD) and genus/species richness (GR/SR) among subfamilies. The MD was quantified by the contours of the pronotum and elytron in dorsal view based on a geometric morphometric approach. The positive correlation between MD and GR was found in all test combinations, but was irrelevant in the species-level test. Interestingly, the correlation between MD and GR was higher than MD and SR in both pronotum and elytron measurements. Additionally, the MD of the pronotum is obviously higher than the MD of the elytron. Our results demonstrate that the geometric morphometric approach could quite accurately reveal diversity patterns of the family Buprestidae. Future studies on different groups, using more characters, more analyses and detailed biological interpretations, are required to fully understand the relationship between MD and SR.
Diagnosis and Management of the Cryopyrin-Associated Periodic Syndromes (CAPS): What Do We Know Today?
Authors: Welzel Tatjana , Kuemmerle-Deschner Jasmin B.
Published: January 2021

The cryopyrin-associated periodic syndromes (CAPS) are usually caused by heterozygous NLRP3 gene variants, resulting in excessive inflammasome activation with subsequent overproduction of interleukin (IL)-1β. The CAPS spectrum includes mild, moderate, and severe phenotypes. The mild phenotype is called familial cold autoinflammatory syndrome (FCAS), the moderate phenotype is also known as Muckle–Wells syndrome (MWS), and the neonatal-onset multisystem inflammatory disease (NOMID)/chronic infantile neurologic cutaneous articular syndrome (CINCA) describes the severe phenotype. The CAPS phenotypes display unspecific and unique clinical signs. Dermatologic, musculoskeletal, ocular, otologic, and neurologic disease symptoms combined with chronic systemic inflammation are characteristic. Nevertheless, making the CAPS diagnosis is challenging as several patients show a heterogeneous multi-system clinical presentation and the spectrum of genetic variants is growing. Somatic mosaicisms and low-penetrance variants lead to atypical clinical symptoms and disease courses. To avoid morbidity and to reduce mortality, early diagnosis is crucial, and a targeted anti-IL-1 therapy should be started as soon as possible. Furthermore, continuous and precise monitoring of disease activity, organ damage, and health-related quality of life is important. This review summarizes the current evidence in diagnosis and management of patients with CAPS.