bluuebunny/crossref_metadata_2025 huggingface dataset:
Establishing and validating a survey for trauma-informed, culturally responsive change across multiple systems
Authors: Moreland-Capuia Alisha , Dumornay Nathalie M. , Mangus Alexandra , Ravichandran Caitlin , Greenfield Shelly F. , Ressler Kerry J.
Published: October 2022

Aim

The purpose of the present study was to establish and validate the Survey for Trauma-Informed Systems Change (STISC), a measure of culturally responsive trauma-informed care (TIC) and services that can be administered to professionals in any field or industry.

Subject/methods

The current study with 262 respondents from judicial, healthcare, political, non-profit, and for-profit settings examined the internal consistency reliability and factor structure of the STISC.

Results

A total of 262 respondents from various industries accessed the pre-training survey. Seven of the 59 items were reassigned to alternate subscales and three subscales were merged following correlation analysis. Internal consistency reliability for subscales based on the final item assignments was good or excellent (lower 95% confidence limits for hierarchical omega ≥ 0.85). The root mean square error of approximation estimate for the confirmatory factor analysis based on final item assignments was acceptable (0.073; 90% CI 0.071, 0.076). Neither the comparative fit index value of 0.76 nor the Tucker–Lewis fit index value of 0.75 approached conventional thresholds for acceptable fit.

Conclusion

Given the absence of a validated alternative, this study supports use of the STISC tool to measure the degree of an individual’s trauma-informed knowledge and positive attitudes toward trauma-informed systems change, as well as trauma-informed practices in the workplace. Further study and refinement will aim to determine whether the STISC survey is sensitive to change, which will provide stronger support for the survey’s potential usefulness as a cost-effective method of standardizing trauma-informed systems change programs across multiple fields and industries.
HALT-D: a randomized open-label phase II study of crofelemer for the prevention of chemotherapy-induced diarrhea in patients with HER2-positive breast cancer receiving trastuzumab, pertuzumab, and a taxane
Authors: Pohlmann Paula R. , Graham Deena , Wu Tianmin , Ottaviano Yvonne , Mohebtash Mahsa , Kurian Shweta , McNamara Donna , Lynce Filipa , Warren Robert , Dilawari Asma , Rao Suman , Mainor Candace , Swanson Nicole , Tan Ming , Isaacs Claudine , Swain Sandra M.
Published: October 2022

Purpose

To assess whether crofelemer would prevent chemotherapy-induced diarrhea (CID) diarrhea in patients with HER2-positive, any-stage breast cancer receiving trastuzumab (H), pertuzumab (P), and a taxane (T; docetaxel or paclitaxel), with/without carboplatin (C; always combined with docetaxel rather than paclitaxel).

Methods

Patients scheduled to receive ≥ 3 consecutive TCHP/THP cycles were randomized to crofelemer 125 mg orally twice daily during chemotherapy cycles 1 and 2 or no scheduled prophylactic medication (control). All received standard breakthrough antidiarrheal medication (BTAD) as needed. The primary endpoint was incidence of any-grade CID for ≥ 2 consecutive days. Secondary endpoints were incidence of all-grade and grade 3/4 CID by cycle/stratum; time to onset and duration of CID; stool consistency; use of BTAD; and quality of life (Functional Assessment of Chronic Illness Therapy for Patients With Diarrhea [FACIT-D] score).

Results

Fifty-one patients were randomized to crofelemer (n = 26) or control (n = 25). There was no statistically significant difference between arms for the primary endpoint; however, incidence of grade ≥ 2 CID was reduced with crofelemer vs control (19.2% vs 24.0% in cycle 1; 8.0% vs 39.1%, in cycle 2). Patients receiving crofelemer were 1.8 times more likely to see their diarrhea resolved and had less frequent watery diarrhea.

Conclusion

Despite the choice of primary endpoint being insensitive, crofelemer reduced the incidence and severity of CID in patients with HER2-positive breast cancer receiving P-based therapy. These data are supportive of further testing of crofelemer in CID.

Trial registration

Clinicaltrials.gov, NCT02910219, prospectively registered September 21, 2016.
Local time-dependent microstructure of aging TEMPO nanofibrillated cellulose gel
Authors: Koochi Hakimeh , Mac Intyre Jonatan , Viitanen Leevi , Puisto Antti , Maleki-Jirsaraei Nahid , Alava Mikko
Published: October 2022

The aging behavior of TEMPO-CNF suspensions is investigated using rheological measurements and experiments involving the free-falling solid sphere. The properties of CNF suspensions, which are formed of water and cellulose fibers with a large aspect ratio, are fundamentally different from those commonly known as model low-density gels. We characterize their aging utilizing SAOS rheometry following a period of shear rejuvenation, measuring the effect of aging time on the observed stress overshoot, and additionally measure the rheological hysteresis under continuous shear. In addition to such tests, which probe the sample at the bulk level, we study their local aging behavior via the Stokes’ experiment. During SAOS, the aging of the material results in a logarithmic growth of the elastic modulus over the first 50 minutes. In the Stokes’ experiment, depending on the sphere size, we find a systematic decrease in the sphere velocity with aging times up to 16 days and identify a range of intermittent particle motion. Based on our experimental evidence, we propose that the aging effect within the TEMPO-CNFs occurs due to the restructuring of fibrous elements by Brownian diffusion and that the aging of the system does not develop homogeneously across the whole sample as a consequence of the wide size distribution of CNFs. Finally, we note that this may be one of the primary reasons why the rheological data on even the same batch of CNFs show a large scatter.

Graphical abstract
Bones and injustices: provenance research, restitutions and identity politics
Authors: Kurzwelly Jonatan
Published: October 2022

The last decade has witnessed increasing numbers of “provenance research” projects investigating the histories of human remains in academic collections and leading to their restitution. Such projects explicitly and implicitly address the historical injustices and their continuities of amassing people’s mortal remains and their subsequent use by those who have appropriated them. This article considers which historical wrongdoings provenance research and restitutions attempt to address and how effective they are in doing so. Firstly, the article points towards the relatively effective recognition of spiritual and emotional injustice. Secondly, it discusses the limited recognition of “race science’s” history and legacies and of its logic’s persistence in a social essentialism that inheres in contemporary handling of such human remains. Thirdly, it discusses how recognition of past oppression, dispossession and exploitation ties to broader political goals and attempts at redistribution.
Longitudinal flow in superhydrophobic channels with partially invaded grooves
Authors: Miyoshi Hiroyuki , Rodriguez-Broadbent Henry , Curran Anna , Crowdy Darren
Published: October 2022

Analytical expressions are derived for the longitudinal flow in a superhydrophobic microchannel where flat menisci in the Cassie state have partially invaded the grooves between no-slip blades. Using these solutions, the effective slip lengths are computed and compared with recent analytical results for unbounded shear flow over the same class of surfaces. Expressions for the first-order corrections to these effective slip lengths when the menisci are weakly curved are also derived. A mathematical connection to superhydrophobic channel flows where the flat menisci are still pinned to the tops of the pillars is also made, resulting in novel analytical expressions for those solutions too.
Toward a Culture-Analytical and Praxeological Perspective on Decision-Making
Authors: Schmidt Robert
Published: October 2022

This article outlines a culture-analytical alternative in, and to, decision science. In contrast to the predominant individualistic and mentalistic conceptions of decision making an empirical and praxeological perspective is proposed. Beginning with empirical processes and situated practices of decision-making, this perspective aims to decenter the decision-making subject. The author revisits Harold Garfinkel’s analyses of actual decision-making behavior amongst jurors in court proceedings and Ludwig Wittgenstein’s reflections on rule-following to develop this critical perspective on decision-making necessities in contemporary culture and everyday life.
Betulin and Its Derivatives Reduce Inflammation and COX-2 Activity in Macrophages
Authors: Szlasa Wojciech , Ślusarczyk Sylwester , Nawrot-Hadzik Izabela , Abel Renata , Zalesińska Aleksandra , Szewczyk Anna , Sauer Natalia , Preissner Robert , Saczko Jolanta , Drąg Marcin , Poręba Marcin , Daczewska Małgorzata , Kulbacka Julita , Drąg-Zalesińska Małgorzata
Published: October 2022

Abstract

Betulin is a heavily studied natural compound for its use as an anticancer or pro-regenerative agent. The structural similarity between betulin to steroids gives rise to the idea that the substance may as well act as an anti-inflammatory drug. This study is the first to describe the anti-inflammatory properties of betulinic acid, betulin, and its derivatives with amino acids 1,4-diaminebutane (Dab), 1,3-diaminepropane (Dap), Ornithine (Orn), and lysine (Lys) on murine macrophages from lymphoma site. The compounds were compared to dexamethasone. To establish the response of the macrophages to the natural compounds, we tested the viability as well as sensitivity to the inflammatory signaling (IFNγR). IL-6 secretory properties and HSP-70 content in the cells were examined. Furthermore, we characterized the effects of compounds on the inhibition of cyclooxygenase-2 (COX-2) activity both in the enzymatic assays and molecular docking studies. Then, the changes in COX-2 expression after betulin treatment were assessed. Betulin and betulinic acid are the low-cytotoxicity compounds with the highest potential to decrease inflammation via reduced IL-6 secretion. To some extent, they induce the reorganization of IFNγR with nearly no effect on COX-2 activity. Conversely, Bet-Orn and Bet-Lys are highly cytotoxic and induce the aggregation of IFNγR. Besides, Bet-Lys reduces the activity of COX-2 to a higher degree than dexamethasone. Bet-Orn is the only one to increase the HSP-70 content in the macrophages. In case of IL-6 reduction, all compounds were more potent than dexamethasone.
Single-beat global atrial mapping facilitates the treatment of short-lived atrial tachycardias and infrequent premature atrial contractions
Authors: Gagyi Rita B. , Noten Anna M. E. , Lesina Krista , Mahmoodi Bakhtawar K. , Yap Sing-Chien , Hoogendijk Mark G. , Wijchers Sip , Bhagwandien Rohit E. , Szili-Torok Tamas
Published: October 2022

Background

Short runs of atrial tachycardias (ATs) and infrequent premature atrial contractions (PACs) are difficult to map and ablate using sequential electrophysiology mapping techniques. The AcQMap mapping system allows for highly accurate mapping of a single atrial activation.

Objectives

We aimed to test the value of a novel dipole charge density-based high-resolution mapping technique (AcQMap) in the treatment of brief episodes of ATs and PACs.

Methods

Data of all patients undergoing catheter ablation (CA) using the AcQMap mapping system were reviewed.

Results

Thirty-one out of 219 patients (male n = 8; female n = 23) had short runs of ATs (n = 23) and PACs (n = 8). The mean procedural time was 155.3 ± 46.6 min, with a mean radiation dose of 92.0 (IQR 37.0–121.0) mGy. Total radiofrequency application duration 504.0 (271.0–906.0) s. Left atrial localization of ATs and PACs was identified in 45.1% of the cases, right atrium localization in 45.1%, and septal origins in 9.8% of the cases. Acute success was achieved in 30/31 (96.8%), and recurrence during the follow-up developed in six patients (19.4%), including four patients with PACs and two patients with short-lived ATs. One patient presented procedure-related groin hematoma as minor complication.

Conclusion

Brief episodes of highly symptomatic ATs and infrequent PACs can be mapped using charge density mapping and successfully ablated with high acute and long-term success rates.
Psychological and Hierarchical Closeness as Opposing Factors in Whistleblowing: A Meta-Analysis
Authors: Batolas Dimitrios , Perkovic Sonja , Mitkidis Panagiotis
Published: October 2022

Although employees are an important means of detecting and preventing misconducts through whistleblowing, many witnesses choose to remain silent. One reason to remain silent is the discomfort of reporting a colleague. Intuitively, employees should be less likely to report a close or trusted colleague, but a previous review suggests that the opposite may actually be true. However, later studies have shown mixed effects of social closeness on whistleblowing. To gain a better understanding of how social closeness affects whistleblowing, we meta-analyzed 22 experimental studies on intentions to blow the whistle. Overall, the studies show no effect of social closeness on whistleblowing intentions, d =  − 0.21, p = .05. However, when separating the studies by type of closeness, we find that psychological closeness has a negative effect, d =  − 0.46, p < .001, while hierarchical closeness has a positive effect, d = .34, p < .001 on whistleblowing intentions. This means that employees are most likely to report misconduct if the perpetrator is at the same hierarchical level in the organization and not a close or trusted friend. Since close psychological bonds are more likely to develop between employees at the same hierarchical level, the two types of closeness may counteract each other. This dilemma could be part of the explanation why so many witnesses choose to remain silent.
How the COVID-19 Pandemic and its Consequences Affect the Presence of and Search for Meaning of Life: A Longitudinal Study
Authors: Baños Rosa Mª , Desdentado Lorena , Vara Mª Dolores , Escrivá-Martínez Tamara , Herrero Rocío , Miragall Marta , Tomás José M.
Published: October 2022

The presence of meaning in life (PML) and the search for meaning in life (SML) are crucial when facing difficult times. Although several theoretical frameworks have tried to explain the dynamics of meaning in life during adversity, empirical evidence about interactions among both constructs using longitudinal designs is scarce. This study examined the trajectories of both PML and SML during the COVID-19 lockdown period in Spain. In total, 220 adults fulfilled an online survey during two periods: a strict and a relaxed lockdown period. Latent growth models showed that both PML and SML declined slightly during the strict lockdown, but they reached a plateau during the relaxed lockdown. Results also showed that age and having a partner predicted higher PML and lower SML at baseline, whereas being male predicted higher scores on PML. PML and SML were negatively associated at baseline, higher SML at baseline was related to a steeper decreasing PML slope during the strict lockdown, and the PML and SML slopes in the relaxed lockdown period were negatively related. This study contributes to better understanding longitudinal fluctuations of meaning in life in situations of adversity.
Orbital-free spherical density functional theory
Authors: Nagy Ágnes
Published: October 2022

Recently, it has been proved that a set of spherically symmetric densities uniquely determines the Coulomb external potential. Utilizing this theorem, a previous method is extended to construct an orbital-free density functional theory. Auxilary spherical non-interacting systems and Kohn–Sham-like equations are constructed. A set of spherical generating functions are defined. These functions have two extra variables and are reduced to the set of spherically symmetric densities if the extra variables are equal to zero. Euler equations are rewritten as Schrödinger-like equations for the square root of the spherically symmetric generating functions. Generalized Pauli potentials are defined, and it is shown that these potentials can be calculated in the knowledge of the generating functions. The Euler equations can be solved with these Pauli potentials.
Optimisation of rural roads planning based on multi-modal travel: a multi-service accessibility study in Nepal’s remote Karnali Province
Authors: Heyns Andries M. , Banick Robert
Published: October 2022

The traditional aim in transportation planning is to maximise gains associated with vehicular travel distances or times, indirectly prioritising populations that live near existing or proposed roads—remote populations that first require hours of walking to reach roads are overlooked. In this paper, rural roads optimisation is performed using a new model that estimates proposed roads’ accessibility gains, considering reductions in vehicular travel time and reductions in walking time required by remote populations to reach them. This ensures that even the most remote populations that may benefit from new roads are included in their evaluation. When presented with a large number of proposed roads and the requirement of determining a plan within a suitable budget, it is often infeasible to construct all proposed roads. In such instances, subsets of well-performing road-combinations that are evaluated with respect to multiple objectives need to be identified for analysis and comparison–for which multi-objective optimisation approaches can be employed. Traditional optimisation approaches return a small number of road-combination plans only, limited to user-specified budget levels and objective weight sets. This paper presents an innovative heuristic solution approach that overcomes such limitations by returning thousands of well-performing solutions scattered across a budget span, and not limited in number to user-specified objective weight sets at fixed budget levels. The heuristic is employed along with a more traditional weighted-sum integer-linear programming approach to determine high-quality road-combination plans selected from 92 roads recently proposed for construction in Nepal’s remote Karnali province. Using these two approaches with inputs from the new multi-modal accessibility model, it is illustrated how rural roads planning can be performed to the benefit of rural populations regardless of their proximity to roads. New planning and analysis benefits of the heuristic are demonstrated by comparing its solutions to those determined by the weighted-sum approach, providing a level of detail and sophistication not previously possible for rural roads planning and analysis.
Use of remote sensing-derived fPAR data in a grapevine simulation model for estimating vine biomass accumulation and yield variability at sub-field level
Authors: Leolini L. , Bregaglio S. , Ginaldi F. , Costafreda-Aumedes S. , Di Gennaro S. F. , Matese A. , Maselli F. , Caruso G. , Palai G. , Bajocco S. , Bindi M. , Moriondo M.
Published: October 2022

Grapevine simulation models are mostly used to estimate plant development, growth and yield at plot scale. However, the spatial variability of pedologic and micro-climatic conditions can influence vine growth, leading to a sub-field heterogeneity in plant vigor and final yield that may be better estimated through the assimilation of high spatial resolution data in crop models. In this study, the spatial variability of grapevine intercepted radiation at fruit-set was used as input for a grapevine simulation model to estimate the variability in biomass accumulation and yield in two Tuscan vineyards (Sites A and B). In Site A, the model, forced with intercepted radiation data as derived from the leaf area index (LAI), measured at canopy level in three main vigor areas of the vineyard, provided a satisfactory simulation of the final pruning weight (r2 = 0.61; RMSE = 19.86 dry matter g m−2). In Site B, Normalized Difference Vegetation Index (NDVI) from Sentinel-2A images was firstly re-scaled to account for canopy fraction cover over the study areas and then used as a proxy for grapevine intercepted radiation for each single pixel. These data were used to drive the grapevine simulation model accounting for spatial variability of plant vigor to reproduce yield variability at pixel scale (r2 = 0.47; RMSE = 75.52 dry matter g m−2). This study represents the first step towards the realization of a decision tool supporting winegrowers in the selection of the most appropriate agronomic practices for reducing the vine vigor and yield variability at sub-field level.
Plastoquinone pool redox state and control of state transitions in Chlamydomonas reinhardtii in darkness and under illumination
Authors: Virtanen Olli , Tyystjärvi Esa
Published: October 2022

Movement of LHCII between two photosystems has been assumed to be similarly controlled by the redox state of the plastoquinone pool (PQ-pool) in plants and green algae. Here we show that the redox state of the PQ-pool of Chlamydomonas reinhardtii can be determined with HPLC and use this method to compare the light state in C. reinhardtii with the PQ-pool redox state in a number of conditions. The PQ-pool was at least moderately reduced under illumination with all tested types of visible light and oxidation was achieved only with aerobic dark treatment or with far-red light. Although dark incubations and white light forms with spectral distribution favoring one photosystem affected the redox state of PQ-pool differently, they induced similar Stt7-dependent state transitions. Thus, under illumination the dynamics of the PQ-pool and its connection with light state appears more complicated in C. reinhardtii than in plants. We suggest this to stem from the larger number of LHC-units and from less different absorption profiles of the photosystems in C. reinhardtii than in plants. The data demonstrate that the two different control mechanisms required to fulfill the dual function of state transitions in C. reinhardtii in photoprotection and in balancing light utilization are activated via different means.
Reciprocity and the matrilineal advantage in European grand-parenting
Authors: Brunello Giorgio , Yamamura Eiji
Published: October 2022

This study proposes reciprocity between parents and children to explain the observed matrilineal advantage in grandparent—grandchildren relationships in Europe. On the one hand, maternal grandparents look after grandchildren more than paternal grandparents do. On the other hand, daughters help their parents with personal tasks more than sons do. This advantage is stronger in the countries of Europe with lower gender equality and lower trust in others, where the traditional view of the family is more likely to prevail.
Digital platforms and entrepreneurial support: a field experiment in online mentoring
Authors: Lall Saurabh A. , Chen Li-Wei , Mason Dyana P.
Published: October 2022

The benefits of entrepreneurial mentorship are well documented, but there is limited research on how entrepreneurs connect with mentors, especially in digital settings. We partnered with an online platform that connects entrepreneurs to potential mentors to conduct a field experiment in online mentoring. Drawing on literature on entrepreneurial mentorship and Social Cognitive Theory, we compared the effects of three interventions on the likelihood of reaching out and making a connection with a mentor in a digital setting. We find that showing entrepreneurs a video of a successful mentor–mentee relationship increases the chances that they will reach out to a potential mentor but does not improve their chances of making a connection. These findings are more pronounced for female entrepreneurs. While not all entrepreneurs adopt the offered interventions, those that make the effort to learn to navigate the online platform and craft a suitable introductory message are successful in establishing a mentoring connection. We discuss these implications for both theory and practice.
Stakeholder roles in sustainable supply chain management: a literature review
Authors: Siems Erik , Seuring Stefan , Schilling Lara
Published: October 2022

Since ecological deterioration and social discrepancy are intensifying, multiple stakeholders are driving companies to incorporate sustainability in their supply chains. Thus, integrating non-traditional supply chain stakeholders, such as non-governmental organizations and competitors, in supply chain practices is essential for achieving a more sustainable supply chain. Hence, this research aims to show how stakeholders and their roles are related to sustainable supply chain management practices. A systematic literature review including 78 peer-reviewed English journal articles published between 2000 and 2020 was conducted. The results suggest that multiple supply chain external and internal stakeholders drive, facilitate, or inspect the implementation of sustainable supply chain management practices. While governmental and non-governmental organizations are key drivers for implementing sustainable supply chain management practices, they can also support their implementation. Moreover, proactive engagement with external supply chain stakeholders facilitates the organizational learning process through capability development, increasing understanding and awareness of sustainability, and creating knowledge. This study strengthens the value of proactive and collaborative measurements to deal with stakeholder issues before putting pressure on a company, which can result in reputation and legitimacy loss. These insights enrich the theoretical debate while explaining stakeholders’ relevance and roles in the sustainable supply chain management context. However, the study has some limitations regarding the chosen sustainable supply chain management and stakeholder constructs and potential within-study bias, offering possibilities for further research.
A new family of modified Gaussian copulas for market consistent valuation of government guarantees
Authors: Cerqueti Roy , Cesarone Francesco , Heusch Maria C. , Mottura Carlo D.
Published: October 2022

This paper deals with a copula-based stochastic dependence problem in the context of financial risks. We discuss the financial framework for assessing the theoretical up-front value of government guarantees on bank liabilities. EU States widely use these contracts to improve the financial system’s stability and manage the banking sector in crisis situations; in Italy, they have also been used to address the consequences of the Covid-19 emergency. From a market viewpoint, we deal with a defaultable guarantee contract where the State-guarantor and the bank-borrower are both subject to default risk, and their risks are interconnected. We show that the classical Gaussian copula is not satisfactory for modeling the dependence among the considered risks. Indeed, using the benchmark market model for credit risk portfolio management, we highlight some contradictory results observed for the up-front values of the guarantee when the default intensity of the guarantor is smaller than that of the borrower. Then, we introduce a new family of modified Gaussian copulas that overcomes the limitations of the standard approach, allowing to determine realistic results in terms of the guarantees “mark-to-model” value when the benchmark market model does not work. Numerical simulations validate the theoretical proposal.
Trophodynamics of Nekton Assemblages and Relationships with Estuarine Habitat Structure Across a Subtropical Estuary
Authors: Whaley Shannon D. , Shea Colin P. , Burd James J. , Harmak Craig W.
Published: October 2022

Understanding the spatiotemporal dynamics of trophic structures, or trophodynamics, is important for assessing the overall condition and function of estuarine ecosystems. We examined spatial and seasonal trophodynamics of nekton assemblages across the seascape of a subtropical estuary (Charlotte Harbor, FL, USA) using historical nekton data from an ongoing monitoring program. We also examined relationships between trophodynamics and the spatial distribution of vegetated habitats, such as salt marshes, mangroves, and seagrass beds, as well as their absence along hardened shorelines (seawalls or riprap) using seascape metrics (area and edge density of habitats within several search radii of sample locations). We found that nekton assemblages in shallow waters (from the shoreline to a depth of ≤ 1.5 m) transitioned from mainly planktivores in the lower Peace and Myakka Rivers to mainly benthivores (those feeding on benthic infauna, epifauna, or seagrass) in the middle and lower portions of Charlotte Harbor. Overall nekton assemblages throughout the estuary appeared to be largely sustained through benthic pathways in areas with abundant seagrass and nearby mangrove habitat, particularly during the cool-dry winter when planktivore densities were seasonally low. The dramatic seasonal decline in planktivore densities we found in the lower rivers may be related to low freshwater inflow and increased predation resulting from seasonal recruitment pulses of several omnivorous species. Trophodynamics linked with seascape metrics of estuarine habitat structure described here may be used as a spatially explicit baseline of the estuarine seascape to monitor ecosystem health as well as parameterize spatial ecosystem models used in fisheries management in Charlotte Harbor and similar subtropical estuaries.
The NET G3 enigma: dealing with a “new” entity
Authors: Raderer Markus , Kiesewetter Barbara
Published: October 2022

Neuroendocrine neoplasms of the gastroenteropancreatic system (GEP-NENs) have historically been graded into well-differentiated neuroendocrine tumors (NETs) G 1 and 2 and undifferentiated neuroendocrine carcinomas (NEC) G3 according to the proliferative index Ki-67, with the latter being larger than 20% for G3 NENs. However, clinical and pathological findings have suggested G3 NENs to be heterogeneous, and the most recent World Health Organization (WHO) classification has further subdivided G3 NENs into NET G3 with differentiated features and a usually lower Ki-67 (20–55%) as opposed to undifferentiated NECs. Currently, however, no standard approach to patients with NET G3 has been defined. As opposed to NET G1/G2, application of somatostatin analogues is not recommended, and the response to platinum-based chemotherapy is inferior when compared to NEC. The objective of this short review is to summarize pathological characteristics as well as therapeutic data obtained in patients with NET G3.
Acceptance of Remote Assistive Robots with and without Human-in-the-Loop for Healthcare Applications
Authors: Nertinger Simone , Kirschner Robin Jeanne , Naceri Abdeldjallil , Haddadin Sami
Published: October 2022

Assistive social robots aim to facilitate outpatient-care including required safety critical measures. Accepting a robot to perform such measures, e.g., operate in close physical interaction for medical examinations, requires human trust towards the robot. Human-in-the-loop (HIL) applications where the robot is teleoperated by a human expert can help the person to accept even risky tasks performed by a robot. Therefore, the assistive humanoid GARMI was designed to enable HIL applications with varying autonomy. In this study, we use GARMI to understand which tasks in the framework of care may be accepted depending on human socio-demographics and user beliefs as well as the level of robot autonomy. Firstly, we seek to understand the general acceptance of GARMI using the Almere questionnaire. Secondly, we ask adults to rate their willingness to use several functionalities of GARMI. Lastly, we investigate the effect of the introduction method of GARMI on user acceptance. We assemble all relevant factors on acceptance to provide direction in the user-centered design process of assistive robots. The results of 166 participants show that alongside others, trust towards the robot and utilitarian variables such as perceived usefulness are the most influencing factors on the acceptance of GARMI and should be considered for the design of robotic semi-autonomous outpatient-services.
InP/ZnS quantum dots synthesis and photovoltaic application
Authors: Pidluzhna Anna , Stakhira Pavlo , Baryshnikov Glib , Zavaraki Asghar Jamshidi , Ågren Hans
Published: October 2022

In the present paper hybrid core–shell InP/ZnS quantum dots were prepared by the one pot synthesis method which does not require additional component injections and which complies more with cost requirements. The synthesized quantum dots were characterized by X-ray diffraction and optical spectroscopy methods. The applicability of the synthesized InP/ZnS core–shell particles in inverted solar cells fabricated with a step-by-step procedure which combines thermal vacuum deposition and spin-coating techniques was investigated. The resulting efficiency of the fabricated inverted solar cell is comparable to that of quantum-dot sensitized TiO2 based solar cells. Therefore, hybrid core–shell InP/ZnS particles can be considered as multifunctional light-harvesting materials useful for implementation in different types of photovoltaic devices, such as quantum dot sensitized solar cells and inverted solar cells.
Using decision theory to understand preservice teachers’ implementations of mathematical modelling
Authors: Hansen Ragnhild
Published: October 2022

In this study, we aim to explain choices that groups of preservice teachers made to implement modelling tasks in primary school. We found that the preservice teachers decided to facilitate everyday-inspired contexts for the tasks and that this could be explained by their reasoning that modelling is supposed to be an activity close to reality. Essentially, the groups preferred two different approaches to introducing students to the tasks: (1) by inviting students to physically participate in situations related to their local communities that were familiar to them (e.g. trash picking), and (2) through pre-structured problems that were recognisable to students (e.g. estimation of the number of beads in an irregular box). We found evidence that the preservice teachers tended towards avoiding focusing on possible mathematical answers to the tasks. This could be explained by lacking experience with how to find approximate solutions, or that the preservice teachers were engaged in observing students’ solution strategies and mathematical behaviour.
Ernst-Wolfgang Böckenförde: Scholar of Law, Religion, and Democracy -
Discussed: Religion, Law, and Democracy: Selected Writings. By Ernst-Wolfgang Böckenförde. Edited by Mirjam Künkler and Tine Stein. Translated by Thomas Dunlap. Oxford: Oxford University Press, 2020. Pp. 480. $65.00 (cloth); Oxford Scholarship Online by subscription (digital). ISBN: 9780198818632. DOI: https://doi.org/10.1093/oso/9780198818632.001.0001.
Authors: Künkler Mirjam , Stein Tine
Published: October 2022

Ernst-Wolfgang Böckenförde (1930–2019) was one of Germany’s foremost postwar legal scholars. He coined or popularized key terms and ideas that have left their mark on postwar German political debate to an extent matched by only few, from the chain of legitimation to the concept of the constitution as an ordering frame, the importance of the idea of subsidiarity in the European Union’s political competency, and his insistence that society must continuously work toward agreement on the things that cannot be voted on: the ultimate agreements in society that lie beyond the ballot box. Böckenförde was a lifelong commentator on Catholic affairs in Germany and involved in several important inner-Catholic reform initiatives. At the age of thirty-one, he became known to a wider German public with an article that presented a critical historical appraisal of the role of the Catholic Church under National Socialism. While still a postdoc, he co-authored a widely publicized critique of Jesuit Gustav Gundlach’s justification on theological grounds of a war of nuclear deterrence. In 1968, he was the first to publish a German edition of De Libertate Religiosa, the final declaration of the Second Vatican Council (Vatican II), and provided an authoritative commentary.
Framing provides reasons
Authors: Levy Neil
Published: October 2022

Framing effects are held to be irrational because preferences should remain stable across different descriptions of the same state of affairs. Bermúdez offers one reason why this may be false. I argue for another: If framing provides implicit testimony, then rational agents will alter their preferences accordingly. I show there is evidence that framing should be understood as testimonial.
The study of rational framing effects needs developmental psychology
Authors: Vasil Jared
Published: October 2022

Experimental research is reviewed which suggests that rational framing effects influence young children's social activities according to a logic of interdependence. However, young children are unlikely to possess some of the elaborate cognitive skills argued in the Target Article to be prerequisite for rational framing effects. Understanding rational framing effects requires understanding their ontogenetic origins.
Framing is a motivated process
Authors: Ainslie George
Published: October 2022

Frames group choices into categories, thus modifying the incentives for them. This effect makes framing itself a motivated choice rather than a neutral cognition. In particular, framing an inferior choice with a high short-term payoff as part of a broad category of choices recruits incentive to reject it; but this must be motivated by its being a test case.
Frames, trade-offs, and perspectives
Authors: Weisel Ori , Zultan Ro'i
Published: October 2022

Bermúdez argues for rational framing effects based on normatively appropriate quasi-cyclical preferences. We suggest that this argument conflates preferences over specific outcomes with preferences over outcome aspects. Instead of implying quasi-cyclical preferences, framing affects decisions through standard economic trade-offs. Nonetheless, we demonstrate that framing can affect behavior through altering perceptions of particular outcome aspects when framing effects are not decomposable.
The Labor of Care in Carceral Spaces: The Work of Resistance in the New York City Jails
Authors: Ludwig Ariel
Published: October 2022

The carceral history of Rikers Island, which now houses nine of the New York City jails, begins with garbage and forced labor. The Municipal Farm on Rikers Island, operated by the Department of Public Charities and Correction, opened in 1884 and served as a “prison farm.” Penal farms were common at that time, but what was not common was the simultaneous use of the island as a landfill. Most of the landmass that now comprises Rikers was formed from the refuse of New Yorkers. As the amount of garbage grew the initially productive farm became plagued by rats and other pests—not to mention fetid smells and poor air quality. This history is felt today on the island, as there are shunts into the earth that spew sickening steam, a constant reminder of its origins.
Oxygen Variability in the Offshore Northern Benguela Upwelling System From Glider Data
Authors: Lovecchio Elisa , Henson Stephanie , Carvalho Filipa , Briggs Nathan
Published: October 2022

Despite their role in modulating the marine ecosystem, variability and drivers of low‐oxygen events in the offshore northern Benguela Upwelling System (BenUS) have been rarely investigated due to the events' episodicity which is difficult to resolve using shipboard measurements. We address this issue using 4 months of high‐resolution glider data collected between February and June 2018, 100 km offshore at 18°S. We find that oxygen (O2) concentrations in the offshore northern Benguela are determined by the subsurface alternation of low‐oxygen Angola‐derived water and oxygenated water from the south at 100–500 m depth. We observe intermittent hypoxia (O2 < 60 μmol kg−1) which occurs on average for ∼30% of the 4 months deployment and is driven by the time‐varying subsurface pulses of Angola‐derived tropical water. Hypoxic events are rather persistent at depths of 300–450 m, while they are more sporadic and have weekly duration at shallower depths (100–300 m). We find extreme values of hypoxia, with O2 minima of 16 μmol kg−1, associated with an anticyclonic eddy spinning from the undercurrent flowing on the BenUS shelf and showing no surface signature. Fine‐scale patchiness and water mass mixing are associated with cross‐frontal stirring by a large anticyclone recirculating tropical water into the northern BenUS. The dominance of physical drivers and their high variability on short time scales reveal a dynamic coupling between Angola and Benguela, calling for long‐term and high‐resolution measurements and studies focusing on future changes of both tropical O2 minima and lateral fluxes in this region.
The Wet Bias of RegCM4 Over Tibet Plateau in Summer Reduced by Adopting the 3D Sub‐Grid Terrain Solar Radiative Effect Parameterization Scheme
Authors: Gu Chunlei , Huang Anning , Zhang Yaocun , Yang Ben , Cai Shuxin , Xu Xiaoke , Luo Jiangxin , Wu Yang
Published: October 2022

The Regional Climate Model Version 4 (RegCM4) with the conventional plane‐parallel radiative transfer scheme severely overestimates the summer precipitation over the Tibetan Plateau (TP) due to the excessive surface heat source, which results from the poor representation of the sub‐grid terrain‐related radiation processes. To realistically describe the surface sub‐grid radiation process in the RegCM4, a 3‐dimensional sub‐grid terrain solar radiative effect (3DSTSRE) parameterization scheme is implemented into the RegCM4 to improve the original plane‐parallel radiative transfer scheme. Results show that adopting the 3DSTSRE scheme in RegCM4 can significantly reduce the summer (June–August) wet bias over the TP produced by the model with the plane‐parallel radiative transfer scheme. Mechanism analysis indicates that the 3DSTSRE scheme largely improves the description of the TP surface energy balance in the RegCM4 by reducing the positive bias of downward surface solar radiation (DSSR). The reduced DSSR leads to the weakened surface heat source and cooler near‐surface air over the TP. Consequently, the local atmospheric circulation adapts to the temperature field as the low‐level anti‐cyclonic (high‐level cyclonic) anomaly over the TP. The adjustment of the temperature and wind field attenuates the water vapor transport, enhances the low‐level atmospheric stability, inhibits the updraft motion, and eventually reduces the rainfall over TP. Although the 3DSTSRE improves the DSSR simulation only during daytime, the precipitation simulation is also improved at nighttime, which is fundamentally attributed to the maintenance of the cooled atmosphere throughout the daytime and nighttime.
Unclonable human-invisible machine vision markers leveraging the omnidirectional chiral Bragg diffraction of cholesteric spherical reflectors
Authors: Agha Hakam , Geng Yong , Ma Xu , Avşar Deniz Işınsu , Kizhakidathazhath Rijeesh , Zhang Yan-Song , Tourani Ali , Bavle Hriday , Sanchez-Lopez Jose-Luis , Voos Holger , Schwartz Mathew , Lagerwall Jan P. F.
Published: October 2022

The seemingly simple step of molding a cholesteric liquid crystal into spherical shape, yielding aCholesteric Spherical Reflector(CSR), has profound optical consequences that open a range of opportunities for potentially transformative technologies. The chiral Bragg diffraction resulting from the helical self-assembly of cholesterics becomes omnidirectional in CSRs. This turns them into selective retroreflectors that are exceptionally easy to distinguish—regardless of background—by simple and low-cost machine vision, while at the same time they can be made largely imperceptible to human vision. This allows them to be distributed in human-populated environments, laid out in the form of QR-code-like markers that help robots and Augmented Reality (AR) devices to operate reliably, and to identify items in their surroundings. At the scale of individual CSRs, unpredictable features within each marker turn them into Physical Unclonable Functions (PUFs), of great value for secure authentication. Via the machines reading them, CSR markers can thus act as trustworthy yet unobtrusive links between the physical world (buildings, vehicles, packaging,…) and its digital twin computer representation. This opens opportunities to address pressing challenges in logistics and supply chain management, recycling and the circular economy, sustainable construction of the built environment, and many other fields of individual, societal and commercial importance.
Sleep-related breathing disorder in non-infectious pulmonary complications after pediatric allogeneic stem cell transplantation
Authors: Ukonmaanaho Elli-Maija , Kirjavainen Turkka , Martelius Laura , Lohi Jouko , Karikoski Riitta , Koskenvuo Minna , Taskinen Mervi
Published: October 2022

Background

Chronic lung problems are a rare but serious complication of allogeneic hematopoietic stem cell transplantation (HSCT). We studied clinical phenotypes and polysomnography appearance of breathing abnormality in late onset non-infectious pulmonary complications (NIPS).

Methods

We reviewed Finnish national reference database between the years 1999 and 2016. We identified 12 children with most severely decreased pulmonary function and performed polysomnography and 24 aged-matched controls out of 325 performed pediatric allogeneic HSCTs.

Results

All patients with NIPS had severely decreased pulmonary function already at 6 months post HSCT with median FEV1 value 42% (interquartile range (IQR) 30–52%) of predicted normal values. Seven children had obstructive and five children more restrictive lung function. Children with obstructive lung function showed laborious breathing (7/7), decreased oxygenation and ventilation-to-perfusion mismatch (6/7), or REM-sleep-related hypoventilation (4/7) on polysomnography. Children with restrictive lung function (5/12) did not show sleep-related breathing disorder.

Conclusions

Children going through allogeneic HSCT who develop severe chronic obstructive lung function are more likely to present with sleep-related hypoxia and hypoventilation than children with restrictive lung function.

Impact

Children with severe obstructive lung function and chronic lung graft-versus-host disease following hematopoietic stem cell transplantation are more likely to present with sleep-related mild hypoxia and hypoventilation than children with restrictive lung disease.

To our knowledge there are no reports on sleep-related breathing disorders and ventilatory function measured by polysomnography in children with pulmonary complications after allogeneic HSCT.

Polysomnography may add to the differential diagnostics between patients with BOS and other non-infectious pulmonary complications.