bluuebunny/crossref_metadata_2025 huggingface dataset:
Biomarkers for Predicting the Occurrence and Progression of Atrial Fibrillation: Soluble Suppression of Tumorigenicity 2 Protein and Tissue Inhibitor of Matrix Metalloproteinase-1
Authors: Sun Wei-Ping , Du Xiao , Chen Jun-Jun
Published: January 2023

Background. Soluble suppression of tumorigenicity 2 protein (sST2) and tissue inhibitor of matrix metalloproteinase (TIMP)-1 are involved in multiple pathogenic pathways, including cardiac remodeling, which is the main pathology of atrial fibrillation (AF). This study aims to investigate the previously unexplored relationship between the serum levels of sST2, TIMP-1, and AF. Methods. This was a prospective cross-sectional study conducted at the Capital Medical University Affiliated Beijing Anzhen Hospital between June 2019 and July 2020, with a total of 359 participants. The clinical characteristics and laboratory results of the patients were compared, and multivariable ordinal logistic regression was used to evaluate the relationship between serum sST2, TIMP-1, and AF. Results. The participants included 110 patients with sinus rhythm (SR), 113 with paroxysmal AF (the paroxysmal AF group), and 136 with persistent AF (the persistent AF group). It was found that the sST2 levels gradually increased in these three groups, from 9.1 (6.7–12.4 pg/ml) in the SR group to 14.0 (10.4–20.8 pg/ml) in the paroxysmal AF group and to 19.0 (13.1–27.8) pg/ml) in the persistent AF group (

p
 
<
 
0.001

). The multivariable ordinal logistic regression model for sST2 and TIMP-1 demonstrated that sST2 had an area under the receiver operating characteristic (ROC) curve (AUC) of 0.797 (95% confidence interval (CI) 0.749–0.846,

p
 
<
 
0.001

) and TIMP-1 had an AUC of 0.795 (95% CI 0.750–0.841,

p
=
0.000

). The multivariable ordinal logistic regression model for sST2 and TIMP-1 showed good discrimination between SR and AF, with an AUC of 0.846, and the addition of clinical factors, such as brain natriuretic peptide (BNP), left atrial diameter, age, and gender, to the biomarker model improved the detection of SR and AF (AUC 0.901). Conclusions. In this cohort study, sST2 and TIMP-1 were associated with AF progression, independent of clinical characteristics and biomarkers. Soluble ST2 and TIMP-1 combined with age, elevated N-terminal-pro hormone BNP(NT-BNP), and an enlarged left atrium were able to demonstrate the progression of AF reliably.
Rapid Characterization and Action Mechanism of the Antidiabetic Effect of Diospyros lotus L Using UHPLC-Q-Exactive Orbitrap MS and Network Pharmacology
Authors: Qin Shihan , Liu Mingjuan , Tang Sunv , Shuai E. , Wang Ziming , Yu Kaiquan , Cai Wei
Published: January 2023

Diospyros lotus L, F. Ebenaceae, is an edible fruit that is widely distributed in China and other Asian countries. Presently, Diospyros lotus L can be used to treat patients with diabetes; however, its chemical composition and pharmacological profiles remain to be elucidated. This study investigated the potential bioactive compounds of Diospyros lotus L and their mechanisms of action using LC-MS and network pharmacology analysis. First, the components of Diospyros lotus L were identify using a reliable strategy for UHPLC-Q-Exactive Orbitrap mass spectrometry combined with parallel reaction monitoring (PRM) in the negative ion mode. Second, a network pharmacology study, including target gene prediction and functional enrichment, was applied to screen the main quality markers of Diospyros lotus L and explore its potential mechanism for the treatment of diabetes. The results showed that a total of 159 compounds were identified from Diospyros lotus L, among which, 140 were reported for the first time. Furthermore, 40 active components, such as quercetin, luteolin, and kaempferol, were proposed as active components of Diospyros lotus L for the treatment of diabetes based on network pharmacology analysis. In addition, 92 relevant antidiabetic targets were mainly related to positive regulation of transcription from the RNA polymerase II promoter, extracellular space, and protein binding, suggesting the involvement of TNF, PI3K-Akt, and HIF-1 signaling pathways in the antidiabetic effect of Diospyros lotus L. Our results may provide a useful approach to identify potential active components and molecular mechanisms of Diospyros lotus L for the treatment of diabetes.
Anthelmintic Agents from African Medicinal Plants: Review and Prospects
Authors: Jato Jonathan , Orman Emmanuel , Duah Boakye Yaw , Oppong Bekoe Emelia , Oppong Bekoe Samuel , Asare-Nkansah Samuel , Spiegler Verena , Hensel Andreas , Liebau Eva , Agyare Christian
Published: January 2023

Soil-transmitted helminthiasis affects more than 1.5 billion people globally and largely remains a sanitary problem in Africa. These infections place a huge economic burden on poor countries and affect livestock production, causing substantial economic losses and poor animal health. The emergence of anthelmintic resistance, especially in livestock, and the potential for its widespread in humans create a need for the development of alternative therapies. Medicinal plants play a significant role in the management of parasitic diseases in humans and livestock, especially in Africa. This report reviews anthelmintic studies that have been conducted on medicinal plants growing in Africa and published within the past two decades. A search was made in various electronic databases, and only full articles in English were included in the review. Reports show that aqueous and hydroalcoholic extracts and polar fractions obtained from these crude extracts form the predominant (80%) form of the extracts studied. Medicinal plants, extracts, and compounds with different chemical groups have been studied for their anthelmintic potential. Polyphenols and terpenoids are the most reported groups. More than 64% of the studies employed in vitro assays against parasitic and nonparasitic nematode models. Egg hatch inhibition, larval migration inhibition, and paralysis are the common parameters assessed in vitro. About 72% of in vivo models involved small ruminants, 15% rodents, and 5% chicken. Egg and worm burden are the main factors assessed in vivo. There were no reports on interventions in humans cited within the period under consideration. Also, few reports have investigated the potential of combining plant extracts with common anthelmintic drugs. This review reveals the huge potential of African medicinal plants as sources of anthelmintic agents and the dire need for in-depth clinical studies of extracts, fractions, and compounds from African plants as anthelmintic agents in livestock, companion animals, and humans.
AMELX and ENAM Polymorphisms and Dental Caries
Authors: Khami Mohammad Reza , Asgari Sahar , Valizadeh Sara , Karami Jafar , Rezaei Arezou , Rezaei Nima
Published: January 2023

Introduction. The variety of the genetic factors playing role in development of dental caries calls for further research in this regard. The aim of the present study was to investigate the differences between caries-free adults and adults with dental caries in terms of polymorphism of caries-related genes (AMELX and ENAM). Methods. The present case-control study was performed on 81 adults aged 18–24 years, 41 caries free, and 40 with a DMFT ≥ 4. A questionnaire containing background and demographic information (such as age, gender, time and type of latest dental check-ups, parent’s education, oral self-care, and the place of residence in the first 12 years of life) was completed by participants at the time of examination. The blood sample was taken from each participant in the EDTA tube, and PCR was performed. Gene diversity of AMELX and ENAM genes was compared between the two groups. Results. Regarding AMELX gene, in the caries-free group 33 (80.5%) and in the group with DMFT ≥ 4, 33 (82.5%) students had TT genotype, but this difference was insignificant. For ENAM gene, in the caries-free group 34 (82.9%) and in the group with DMFT ≥ 4, 39 (97.5%) students had TT genotype, but this difference was insignificant (P value = 0.048, CI 95%:0.02–1.27, and OR = 0.145). Conclusion. There was no relationship between TT and TC genotypes of single nucleotide polymorphism of AMELX and ENAM gene and susceptibility to dental caries, but with increasing sample size, there may be a relationship between SNP of ENAM gene and being caries free.
Analysis of Cases with Cerebrospinal Fluid Characteristics Similar to Tuberculous Meningitis
Authors: Cao Duanhua , Wang Tingting , Wang Yali , Han Jingzhe
Published: January 2023

Purpose. The diagnosis of tuberculous meningitis (TBM) is difficult and relies on the patient’s clinical presentation and initial cerebrospinal fluid testing. Treatment outcomes for some patients with early consideration of TBM meningitis are often poor. Patients and Methods. In this study, we retrospectively analyzed 24 non‐TBM patients whose early changes of cerebrospinal fluid were similar to those of TBM through the second‐generation cerebrospinal fluid sequencing technology. Results. All patients included in this study had an acute onset, including 5 patients with a history of upper respiratory tract infection, 9 patients with fever, 6 patients with headache, 5 patients with psychiatric symptoms, 6 patients with cognitive impairment, 9 patients with signs of meningeal irritation, and 6 patients with seizures. Sixteen patients presented with altered content and level of consciousness during their admission. The leukocyte counts (median, 124.0 × 106/L) and total protein concentrations (median, 1300 mg/L) were higher than normal reference values in all patients, whereas glucose (median, 1.345 mmol/L) and chloride concentration values (average, 111.7 ± 5.2 mmol/L) were lower than normal reference values. The patients included 2 cases of Liszt’s meningitis, 2 cases of Brucella infection in the CNS, 4 cases of Varicella zoster virus encephalitis, 2 cases of human herpes simplex virus type 1, 2 cases of lupus encephalopathy, 2 cases of anti‐NMDAR receptor encephalitis, 2 cases of meningeal carcinomatosis, 5 cases of cryptococcal meningitis, 2 cases of CNS sarcoidosis, and a case of invasive Rhizopus oryzae infection. All patients were tested for NGS in cerebrospinal fluid. Eight patients were diagnosed with anti‐NMDAR encephalitis, meningeal carcinomatosis, lupus encephalopathy, and CNS sarcoidosis. Nine patients experienced death; 15 patients had a good prognosis and left no significant sequelae. Conclusion. The analysis of patients with TBM‐like cerebrospinal fluid changes will help improve the diagnostic accuracy of the disease and reduce misdiagnosis and underdiagnosis.
Methodical support of the structural-functional model of physical self-development of girls - future officers in the process of physical education
Authors: Sliusarchuk Victor
Published: January 2023

The conducted research was aimed at developing the content for the implementation into practice of the pedagogical model of forming the readiness of girls - future officers for physical self-development in the process of physical education at the military academy. Adequate research methods were used to achieve this goal, including analysis, synthesis, systematization, generalization, and theoretical modeling. Sources of information were selected from science metric databases Scopus, SPORT Discus, Web of Science, university libraries, using keywords. The study of information from literary sources proved the lack of adequate methodical support for the model designed by us for the formation of readiness of girls - future officers for physical self-development in the process of physical education in the military academy. In this regard, appropriate methodological support was developed, the basis of which was the following principles: preliminary design of the educational process and its subsequent reproduction in practice; diagnostic goal setting; structural and content integrity of the pedagogical process; the presence of the content of this process and apprenticeship with initial parameters; the determined direction of the process as totality of diagnostic expediency;  objectivity of control over its results. The methodological support developed for the designed model takes into account innovative approaches, modern progressive ideas and the provisions of educational technologies, but requires experimental verification of its effectiveness in achieving the planned result.
Percentage of Appearance of Physical Condition Applications for Badminton Athletes Aged 10-12 Years Old Based on Android Smartphone
Authors: Pambudi Titis , Rahayu Setya , Mukarromah Siti Baitul
Published: January 2023

Badminton games can run well, mastery of techniques or basic game skills is needed. Badminton players must also have good physical abilities. There needs to be an application that supports the performance of the coach. The purpose of creating a product is to realize an attractive design for coaches, especially badminton. The purpose of this study was to determine the percentage of physical condition application displays for badminton athletes aged 10-12 years based on android smartphones. This study uses a survey-based quantitative descriptive method. The population of this study consisted of coaches at badminton clubs in Boyolali District. The sample in this study amounted to 15 coaches at the badminton club in Boyolali Regency were taken using a purposive sampling technique. Data collection techniques in this study used a questionnaire instrument with a Likert scale. Data analysis used SPSS version 25. The results showed that the percentage of physical condition application displays for badminton athletes aged 10-12 years based on Android smartphones in the very good category obtained a percentage of 93.33% with a total of 14 coaches and a good percentage of 6.67 % with a total of 1 coach. So it can be concluded that this application has a very good appearance in the view of the badminton coach.
Chronic Prostatitis / Chronic Pelvic Pain Syndrome – problematic common disease. Current knowledge on etiology, diagnosis and treatments
Authors: Żołyniak Wojciech , Żaba Ziemowit , Warzyszak Paweł , Małek Róża , Milczek Maria , Hawranik Izabela , Lisowska Aleksandra , Tomasik Mikołaj , Niski Szymon , Skrzypek Mateusz
Published: January 2023

Introduction:
Nonbacterial prostatitis (CNP) also known as chronic pelvic pain syndrome (CPPS) is a condition with an incompletely understood etiology. Chronic prostatitis is diagnosed when symptoms of prostatitis persist for more than 3 months and it is difficult to treat. The causes are not fully understood. Among the many possible causes are stress, psycho-emotional disorders, hormonal disorders and autoimmune disorders. The main symptom is pain usually felt in the perineum, at the base of the penis, in the anal area, sometimes over the pubic symphysis. This pain can radiate to the penis and scrotum.
 
Aim of the study:
Summary of current knowledge on the treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome.
 
Material and methods:
Review of PubMed articles using the following keywords: “nonbacterial chronic prostatitis”, “abacterial chronic prostatitis” and “chronic pelvic pain syndrome”.
 
Results:
Complete cure in non-bacterial chronic prostatitis is rare. Due to the lack of knowledge of the cause of chronic prostatitis, there is no effective treatment for this disease. Although the pathogen is rarely found in the patients studied, many patients show improvement after antibiotic therapy. In addition, anti-inflammatory drugs, alpha blockers and neuromodulators are used. Physical therapy also has proven benefits in relieving symptoms.
 
Conclusion:
CNP is a frustrating disease for many doctors and patients. Although it is not yet completely understood, we have made significant progress in the evaluation and treatment of this disease over the past several decades. Physicians need to move away from outdated algorithms that often result in endless courses of antibiotics and embrace multimodal therapy, which provides better results than other treatment strategies.
Herbal Remedies in Post-COVID Trauma: A Systematic Review
Authors: Dhane Rupali Manohar , Shinde Ravikumar Bapurao
Published: January 2023

ABSTRACT: The world has faced huge challenges throughout the endemic of COVID-19. The survivors of Covid too are facing health difficulties. The non-availability of specific treatments made researchers search for all the possible treatment regimens including traditional medicines. India has the greatest culture of Ayurveda. Indian government’s AYUSH ministry has granted permission for use of ancient systems of medicine for treatment of some of the COVID-19 cases, especially which are not at advanced stages. Along with this certain reports are there which have shown the positive outcomes of Ayurvedic treatment of COVID-19. However, it is more beneficial to build the immune system of the host from a large population and its health perspective to avoid widespread infection and control the potency of the infectious viral particles. A vaccine can offer protection by boosting specific immunity in the host at the same time non-specific ways to improve host immunity are suggestible. This has carved a path for the use of ancient Indian therapeutic methods such as Ayurveda and Yoga. Although there are many general articles where the home remedies have suggested but, more scientific references are required to document the ayurvedic medicines for Covid related ailments. In this review, an attempt is made to organize available evidences of usefulness of Ayurveda, Yoga, in COVID-19.
Overview on Development and Validation of Force Degradation Studies with Stability Indicating Methods
Authors: Chandramore Kavita , Sonawane Sandeep
Published: January 2023

ABSTRACT: This article provides an overview on Development and Validation of Force degradation study with Stability Indicating Methods (SIMs) for drug substances. Different stress conditions (hydrolysis, oxidation, thermal, and photolytic conditions) are applied to drugs compounds during a process known as forced degradation, and as a result, various degradation products are created. The major purpose of these investigations is to assess a molecule's stability under accelerated settings. It is well recognized that the stability of molecules affects the regulatory documentation process, the choice of appropriate storage and packaging conditions, and the choice of formulation. The deficiencies of reported methods in terms of regulatory requirements are highlighted. This article is to provide appropriate International conference of harmonization (ICH) criteria for force degradation study and to discuss the methodical process for creating verified SIAMs. The aspects of Mass balance in SIMs are discussed and technique used in SIMs were highlighted. Recent advance in stability indicating methods include characterization of degrdant sample and in-vitro toxicity prediction are addressed. Background of force degradation study with stability indicating methods with respect to international author and national author are discussed.
Design, Synthesis, Computational Docking and Biological Evaluation of Novel 4-Chloro-1,3-Benzoxazole Derivatives as Anticancer Agents
Authors: Fathima Anees , Vagdevi H. M. , Shafeeulla R. Mohammed , Afroz Lubna , Shreedhara S. H.
Published: January 2023

ABSTRACT: An efficient, cost effective and ecologically safe method for the design of series of novel 2-[(4-chloro-1,3-benzoxazol-2-yl)sulfanyl]-N'-[phenylmethylidene] acetohydrazides 5(a-j) have been synthesized by fusing 2-[(4-chloro-1,3-benzoxazol-2-yl)sulfanyl] acetohydrazide with substituted aromatic aldehyde. The prepared compounds were characterized via LC-MS, IR, 1H NMR, 13C NMR and C, H, N analysis technique. All the synthesized compounds were evaluated for biological potency, which includes antimicrobial, antifungal, antioxidant and anticancer activities. The compounds 5a, 5b, 5d, 5e, 5g and 5h showed appreciable antimicrobial, MIC and antioxidant activity. Further, it was also noticed that the prior mentioned compounds showcased more than 70% of cell viability. We also performed molecular docking for all the synthesized compounds and examined their binding affinities to the anticancer receptor 2A91 to qualitatively elucidate their anticancer activity. The data generated from the molecular modeling and the values obtained from the biological screening were correlated.
Formulation and Evaluation of Mouth Dissolving Tablet Rivaroxaban and its Validation
Authors: B. Borse Laxmikant , Bendale Atul R. , L. Borse Sandhya , D. Naphade Vaishali , G. Jadhav Anil
Published: January 2023

ABSTRACT: The foremost intention of present research was the preparation and assessment of mouth dissolving formulation Rivaroxaban and its validation. During present work, this tablet was formulated by straight compression technique by means of Cros-carmellose sodium and Sodium starch glycolate as super-disintegrants (concentration of 2, 4, 6%) and Avicel 102 as a binder. The formulated preparations were exposed to different consideration parameters like hardness test, friability test, disintegration test, release of drug and content of drug. The calibration curve of API using solvent phosphate buffer pH 6.8 was carried out. All prepared formulations exposed to different assessment parameters have shown the findings within prescribed limit. Due to the large concentration of super disintegrants in F8, disintegration time can reach 29±0.06 seconds. In used buffer, drug release was calculated at intervals of 0, 2, 4, 6, 8, 10, and 12 minutes. The F8 demonstrates 96.5±0.567 percent medication release. UV spectrophotometric validation was performed for the quantification of Rivaroxaban in bulk. Rivaroxaban was estimated at 247nm in phosphate buffer 6.8. The linearity range was observed 2–12µg/ml.
Impact of Nutrition Intervention Among Mahatma Gandhi National Rural Employment Guarantee Scheme (MGNREGS) Women Beneficiaries in Salem District, Tamil Nadu, India
Authors: Parameshwari S.
Published: January 2023

The study was undertaken to understand the impact of MGNREGS on the livelihood and nutritional status of women in Salem District, Tamil Nadu, India. The primary aim was to assess the socio-demographic, anthropometric, biochemical, clinical and dietary aspects. After non-formal nutrition education all parameters were re-assessed for impact analysis. The cross-sectional research design was utilized to estimate the prevalence of the outcome of interest for a given population. Among 1000 selected MGNREGS women beneficiaries, 500 were taken as samples by random sampling technique in 20 rural development blocks aged 20 to >60 years. A structured questionnaire was used to collect all the information. The data were analyzed for mean, standard deviation and two-tailed test with statistical significance level of (p<0.05) by SPSS 14.0 software. After intervention, improvement in waist-hip ratio was proven to be statistically significant (p=0.044); Comparing the percentage of each physical sites assessed clinically before and after nutrition intervention, Z-test was taken to ensure where the improvement was statistically significant (p<0.05). Nutritional intervention was carried out in their workplace, it is a cost-effective, feasible method and good option to create a higher level of awareness and standard of living among MGNREGS women beneficiaries.
Toxicity Study of Chlorzoxazone and Isosorbide Dinitrate using Chick Embryo
Authors: Tajanpure Anjali B. , Dashputre Neelam L. , Udavant Pavan B. , Kakad Smita P. , S.Sandhan Varsha , P. Deshmukh Pranali
Published: January 2023

Number of potential drugs are underutilized due to a lack of availability of teratological data. Isosorbide Dinitrate is a saviour drug in angina prophylaxis while chlorzoxazone is a skeletal muscle relaxant and there is no adequate teratogenic study performed till date. This study aims to assess the teratological effect of these drugs on vital organs using the chick embryo model. White Leghorn’s (Gallus gallus domesticus) fertilised chicken eggs were acquired from shivneri agro and hatcheries Nashik and divided into five groups (n=10) as Control, nonteratogenic, teratogenic, chlorzoxazone, and Isosorbide Dinitrate. The drug was injected via yolk inoculation and after inoculation; the eggs were re-incubated at 37.5-37.8°C and 50-60% RH for 21 days. Then the embryos were harvested and evaluated for morphological and histopathological changes. The gross macroscopic examination of Isosorbide Dinitrate and chlorzoxazone treated chicks were normal. The development of the embryo was found shunted in Isosorbide Dinitrate treated group. Microscopic abrasions found in Isosorbide Dinitrate treated group are myocardial congestion, hemorrhage, hydropic degeneration, dislocation of the nucleus, splitting of cells, and infiltration of cells at all three doses. No teratogenic response was observed in chlorzoxazone treated group hence found to be safe. Teratogenic effect of Chlorzoxazone and isosorbide dinitrate in chick embryo provided notable details. Chlorzoxazone was found to be safe in chick embryos in the developmental phase, While Isosorbide dinitrate at highest dose was found toxic and so, it is inadvisable for its utilization in pregnancy.
Geriatric Friendly Medicine Reminder Device Powered by Visual, Voice and IOT Assistance System
Authors: Das Nimish Sunil
Published: January 2023

Any medical care must include regular consumption of the correct dose at the precise time. Because they are more likely to have chronic conditions, older persons consume more medications than younger adults. The majority of medications are used for years, while only a few are used for a brief period. Based on many research investigations, it has been discovered that on average, older individuals take 3 to 5 prescription drugs, and that owing to fading memory impairments, it becomes difficult for them to remember the dosage time and quantity. The dose is effective if it is given at the precise time and in the correct quantity; otherwise, the patient's health would deteriorate. This study proposes a medicine reminder device based on an algorithm that addresses and eliminates difficulties experienced by older adults, such as remembering time, name, quantity or amount of dose, with some specific description, feedback and assistance mechanisms. The device employs a system clock for reminders based on the time inputted, a television display for presenting medicine and meal images, and a speaker for voice help. Finally, a rack of devices is used to pick up the right dose, and a trigger feedback device is employed to notify the website that the drug has been taken.
Evaluation of the Internal Morphology of Antennal Sensilla in Scirpophaga Incertulas for Male and Female by Scanning Electron Microscopy
Authors: Bandameedhi Anusha , Mamidala Praveen
Published: January 2023

The Scirpophaga incertulas (Walker), trivial name Yellow Stem Borer (YSB) is a serious pest contributing to significant yield loss to rice. YSB detects host/mate cues through olfactory receptors (sensilla) on antennae, which is critical for its survival, adaptability, and perpetuation. Though YSB is a destructive pest, its mechanism of olfaction is poorly understood. Using a scanning electron microscope, it is attempted to detect distinct sensilla, decode their characteristics, and compare the antennal sensilla of both males and females. Sensilla trichodea (S.T), Sensilla chaetica (S.Ch), Sensilla styloconica (S.St), Sensilla squamiformia (S.Sq), Sensilla coeloconica (S.Co), Sensilla cavity, and Bőhm bristles (BB) are the seven distinct kinds and subtypes of sensilla are recognized. Sexual dimorphism was observed in the arrangement of scales over the antenna in males and females. Interestingly, among the subtypes, the S.T-I was observed only in males. Furthermore, Sensilla coeloconica without a fence (type II) noticed in our studies was also reported earlier in other monophagous lepidopteran pests. The statistical analysis of the number and size of sensilla clearly indicates their involvement in sexual differentiation. This study may help in better understanding the processes of communication, identification of plant volatiles, oviposit site, and mate in YSB.
Fluoroscopic and radiostereometric analysis of a bicruciate-retaining versus a posterior cruciate-retaining total knee arthroplasty: a randomized controlled trial
Authors: Mills Kelly , Wymenga Ate B. , Bénard Menno R. , Kaptein Bart L. , Defoort Koen C. , van Hellemondt Gijs G. , Heesterbeek Petra J. C.
Published: January 2023

Aims

The aim of this study was to compare a bicruciate-retaining (BCR) total knee arthroplasty (TKA) with a posterior cruciate-retaining (CR) TKA design in terms of kinematics, measured using fluoroscopy and stability as micromotion using radiostereometric analysis (RSA).

Methods

A total of 40 patients with end-stage osteoarthritis were included in this randomized controlled trial. All patients performed a step-up and lunge task in front of a monoplane fluoroscope one year postoperatively. Femorotibial contact point (CP) locations were determined at every flexion angle and compared between the groups. RSA images were taken at baseline, six weeks, three, six, 12, and 24 months postoperatively. Clinical and functional outcomes were compared postoperatively for two years.

Results

The BCR-TKA demonstrated a kinematic pattern comparable to the natural knee’s screw-home mechanism in the step-up task. In the lunge task, the medial CP of the BCR-TKA was more anterior in the early flexion phase, while laterally the CP was more posterior during the entire movement cycle. The BCR-TKA group showed higher tibial migration. No differences were found for the clinical and functional outcomes.

Conclusion

The BCR-TKA shows a different kinematic pattern in early flexion/late extension compared to the CR-TKA. The difference between both implants is mostly visible in the flexion phase in which the anterior cruciate ligament is effective; however, both designs fail to fully replicate the motion of a natural knee. The higher migration of the BCR-TKA was concerning and highlights the importance of longer follow-up. Cite this article: Bone Joint J 2023;105-B(1):35–46.
Clinical outcomes after surgery for cervical radiculopathy performed in public and private hospitals
Authors: Danielsen Elisabet , Gulati Sasha , Salvesen Øyvind , Ingebrigtsen Tor , Nygaard Øystein P. , Solberg Tore K.
Published: January 2023

Aims

The number of patients undergoing surgery for degenerative cervical radiculopathy has increased. In many countries, public hospitals have limited capacity. This has resulted in long waiting times for elective treatment and a need for supplementary private healthcare. It is uncertain whether the management of patients and the outcome of treatment are equivalent in public and private hospitals. The aim of this study was to compare the management and patient-reported outcomes among patients who underwent surgery for degenerative cervical radiculopathy in public and private hospitals in Norway, and to assess whether the effectiveness of the treatment was equivalent.

Methods

This was a comparative study using prospectively collected data from the Norwegian Registry for Spine Surgery. A total of 4,750 consecutive patients who underwent surgery for degenerative cervical radiculopathy and were followed for 12 months were included. Case-mix adjustment between those managed in public and private hospitals was performed using propensity score matching. The primary outcome measure was the change in the Neck Disability Index (NDI) between baseline and 12 months postoperatively. A mean difference in improvement of the NDI score between public and private hospitals of ≤ 15 points was considered equivalent. Secondary outcome measures were a numerical rating scale for neck and arm pain and the EuroQol five-dimension three-level health questionnaire. The duration of surgery, length of hospital stay, and complications were also recorded.

Results

The mean improvement from baseline to 12 months postoperatively of patients who underwent surgery in public and private hospitals was equivalent, both in the unmatched cohort (mean NDI difference between groups 3.9 points (95% confidence interval (CI) 2.2 to 5.6); p < 0.001) and in the matched cohort (4.0 points (95% CI 2.3 to 5.7); p < 0.001). Secondary outcomes showed similar results. The duration of surgery and length of hospital stay were significantly longer in public hospitals. Those treated in private hospitals reported significantly fewer complications in the unmatched cohort, but not in the matched cohort.

Conclusion

The clinical effectiveness of surgery for degenerative cervical radiculopathy performed in public and private hospitals was equivalent 12 months after surgery. Cite this article: Bone Joint J 2023;105-B(1):64–71.
Higher complication rate after nail compared with plate fixation of ankle fractures in patients aged 60 years or older: a prospective, randomized controlled trial
Authors: Stake Ingrid K. , Ræder Benedikte W. , Gregersen Martin G. , Molund Marius , Wang Johan , Madsen Jan E. , Husebye Elisabeth E.
Published: January 2023

Aims

The aim of this study was to compare the functional and radiological outcomes and the complication rate after nail and plate fixation of unstable fractures of the ankle in elderly patients.

Methods

In this multicentre study, 120 patients aged ≥ 60 years with an acute unstable AO/OTA type 44-B fracture of the ankle were randomized to fixation with either a nail or a plate and followed for 24 months after surgery. The primary outcome measure was the American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot score. Secondary outcome measures were the Manchester-Oxford Foot Questionnaire, the Olerud and Molander Ankle score, the EuroQol five-dimension questionnaire, a visual analogue score for pain, complications, the quality of reduction of the fracture, nonunion, and the development of osteoarthritis.

Results

At 24 months, the median AOFAS score was equivalent in the two groups (nail 90 (interquartile range (IQR) 82 to 100), plate 95 (IQR 87 to 100), p = 0.478). There were statistically more complications and secondary operations after nail than plate fixation (p = 0.024 and p = 0.028, respectively). There were no other significant differences in the outcomes between the two groups.

Conclusion

The functional outcome after nail and plate fixation was equivalent; however, the complication rate and number of secondary operations was significantly higher after nail fixation. These results suggest that plate fixation should usually be the treatment of choice for unstable ankle fractures in the elderly. Cite this article: Bone Joint J 2023;105-B(1):72–81.
Thin highly cross-linked polyethylene liners combined with large femoral heads in primary total hip arthroplasty show excellent survival and low wear rates at a mean follow-up of 12.8 years
Authors: Fransen Bas L. , Bengoa Francisco J. , Neufeld Michael E. , Sheridan Gerard A. , Garbuz Donald S. , Howard Lisa C.
Published: January 2023

Aims

Several short- and mid-term studies have shown minimal liner wear of highly cross-linked polyethylene (HXLPE) in total hip arthroplasty (THA), but the safety of using thinner HXLPE liners to maximize femoral head size remains uncertain. The objective of this study was to analyze clinical survival and radiological wear rates of patients with HXLPE liners, a 36 mm femoral head, and a small acetabular component with a minimum of ten years’ follow-up.

Methods

We retrospectively identified 55 patients who underwent primary THA performed at a single centre, using HXLPE liners with 36 mm cobalt-chrome heads in acetabular components with an outer diameter of 52 mm or smaller. Patient demographic details, implant details, death, and all-cause revisions were recorded. Cox regression and Kaplan-Meier survival was used to determine all-cause and liner-specific revision. Of these 55 patients, 22 had a minimum radiological follow-up of seven years and were assessed radiologically for linear and volumetric wear.

Results

Overall survival rate for all-cause revision was 94.5% (95% confidence interval (CI) 81.7% to 97.2%) at a mean follow-up of 12.8 years (10.9 to 18.7). Three patients were revised, none for liner wear, fracture, or dissociation. A total of 22 patients were included in the radiological analysis (mean follow-up 9.9 years (7.5 to 13.7)). Mean linear liner wear was 0.085 mm (95% CI -0.086 to 0.257) and the volumetric wear rate was 11.097 mm3/year (95% CI -6.5 to 28.7).

Conclusion

Using HXLPE liners with 36 mm heads in 52 mm acetabular components or smaller is safe, with excellent survival and low rates of linear and volumetric wear at medium-term follow-up. Patients did not require revision surgery for liner complications such as fracture, dissociation, or wear. Our results suggest that the advantages of using larger heads outweigh the potential risks of using thin HXLPE liners. Cite this article: Bone Joint J 2023;105-B(1):29–34.
PRAGMATISMO: A CONEXÃO ENTRE A TEORIA E A PRÁTICA
Authors: Mendonça Octavio Ribeiro de , Oyadomari José Carlos Tiomatsu , Lima Ronaldo Gomes Dultra de
Published: January 2023

Objetivo: Diante das críticas recorrentes ao distanciamento entre a pesquisa acadêmica e as necessidades emanadas da prática profissional, a abordagem intervencionista tem sido entendida como uma das alternativas que pode mitigar esse distanciamento e produzir resultados relevantes para a prática profissional. Alguns modelos foram desenvolvidos para a realização de pesquisas intervencionista que, embora úteis, não possuem a abrangência do método pragmático O objetivo desse ensaio é provocar uma reflexão sobre a utilização desse método nas pesquisas da área de Contabilidade e Gestão para a solução de problemas complexos relacionados à prática profissional.

Método: Esse ensaio foi desenvolvido por meio de uma análise crítica de textos relacionados ao Pragmatismo, abrangendo desde aqueles classificados como seminais, até os mais recentes focados na de Contabilidade e Gestão.

Discussão: Esse ensaio sugere que a utilização do método pragmático pode constituir mais uma alternativa válida para a pesquisa na área de Contabilidade e Gestão, notadamente naquelas que envolvem problemas práticos complexos.

Contribuições: De particular interesse para as pesquisas no campo contábil e organizacional, notadamente aquelas de caráter intervencionista, é a utilização do raciocínio abdutivo na formulação de hipóteses alternativas e provisórias no decorrer do processo do Inquiry, hipóteses essas que, evidentemente, deverão ser posteriormente testadas com o rigor científico necessário.
PERFIL E NATUREZA CONTINGENTE DA DÍVIDA ATIVA PREVIDENCIÁRIA BRASILEIRA ENTRE 2012 E 2020
Authors: Almeida dos Santos Graziele , Lima Diana Vaz de , Driemeyer Wilbert Marcelo
Published: January 2023

Objetivo: analisar a capacidade do Governo brasileiro na recuperação de recebíveis oriundos da dívida ativa previdenciária (DAP).
Método: é apresentado o fluxo do processo de registro e classificação de probabilidade de pagamento da DAP, abrangendo saldos, pagamentos, tempo de inscrição e demais detalhamentos de saldos. Na sequência é analisada a recuperabilidade da DAP com o uso de estatística descritiva dos dados da DAP disponíveis na Prestação de Contas do Presidente da República no Balanço Geral da União (BGU) e no sítio da Procuradoria Geral da Fazenda Nacional (PGFN), contemplando o período de 2012 a 2020, a partir da classificação do rating estabelecida pela Portaria nº 293/2017
Resultados: os achados da pesquisa mostram que (i) houve crescimento do montante de valores inscritos a título de DAP no período; (ii) enquanto o estoque da DAP cresceu de forma exponencial em relação ao produto interno bruto (PIB), a recuperação desses valores permaneceu relativamente constante; (iii) 64,8% dos valores registrados no período eram correspondentes a créditos irrecuperáveis ou com baixa probabilidade de recuperação. Portanto, é baixa a capacidade de recuperação dos recebíveis oriundos da dívida ativa previdenciária brasileira, evidenciando a natureza contingente desses valores.
Contribuições: o estudo ratifica os achados da literatura sobre o baixo nível de recuperação de recebíveis e seu acúmulo duvidoso nas demonstrações contábeis do setor público, e alerta sobre as discrepâncias observadas nas bases de dados oficiais que tratam da dívida ativa previdenciária brasileira.
Um Debate Polifônico sobre o Orçamento Público “Moderno” no Brasil e suas Implicações para a Contabilidade
Authors: Bartoluzzio Alann Inaldo Silva de Sá , Cruz Cláudia Ferreira da , Dias Lidiane Nazaré da Silva , Diniz Josedilton Alves , Sauerbronn Fernanda Filgueiras
Published: January 2023

Objetivo: Produzir uma pensata a partir de diferentes perspectivas sobre o debate orçamentário no Brasil para a articulação do campo com as questões que envolvem o orçamento público e suas implicações sociais, políticas, institucionais, acadêmicas, entre outras.

Método: Em uma perspectiva construtivista, pesquisadores com diferentes bases onto-epistêmicas desenvolveram reflexões a partir das suas experiências teóricas e práticas antecedentes. Esse material foi articulado em dois encontros junto à comunidade interessada, sendo o primeiro realizado no XVI Anpcont e o segundo mediado pelo Observatório de Gestão e Accountability (OGA/UFRJ). Com base nesses eventos, seis perspectivas ao debate orçamentário foram estruturadas e propostas para a construção de uma discussão abrangente sobre o orçamento público no Brasil. 

Resultados: A integração de diferentes visões permitiu a produção de uma discussão ampla, plural e multiparadigmática sobre as questões que tangenciam o orçamento público. Não obstante, a integração teórica, conceitual e metodológica a partir de um processo colaborativo, como o proposto nesta pensata, viabiliza a construção de sentidos outros não apenas para o orçamento, mas, sobretudo, para a contabilidade nos/dos governos.

Contribuições: Prospectamos que esta iniciativa seja reconhecida como abrangente e conciliatória para o desenvolvimento teórico, conceitual e prático do orçamento governamental e da contabilidade pública, e que, a partir desse material, a comunidade encontre possibilidades de integração, articulação e engajamento para o avanço do debate em curso.
The Effect of Emotion Change Puzzle Media on Visual-Spatial Intelligence for Early Childhood Education
Authors: Mubaroroh Arini , Hidayah Nur , Pramono Pramono
Published: January 2023

Purpose – This study aims to determine the effect of emotion change puzzle media on visual-spatial intelligence in children aged 5-6 years at TK ABA 39 Malang City.Design/methods/approach – The method used in this study is an experimental method using a pre-experimental design by choosing an Intact-Group Comparison design. The research subjects totaled 30 children who were children aged 5-6 years in TK ABA 39 Malang City. The Analysis used in this study is a normality test, homogeneity test, and hypothesis test.Findings – The results of data analysis, and the validity test obtained. The validity test obtained the tcount test 0.053 ≥ from ttable -0.601 which means there is an increase in visual-spatial intelligence in children aged 5-6 years. The standard value of the post-test results is higher than the standard value of the post-test results, namely the experimental pre-test 7.12, pre-test control 7.38, experimental post-test 10.79, and the control post-test 10.26.Research implications/limitations – This study concluded that the emotion change puzzle media has a significant influence on the visual-spatial intelligence of children aged 5-6 years in TK ABA 39 Malang City.Practical implications – The results show that using media emotion change puzzle to children’s learning media can be done by watching animated videos telling stories about various kinds of expressions.Originality/value – This study highlight that emotion change puzzle media can be alternative learning tools that improve children’s visual-spatial intelligence.Paper type: Research paper
Burning Skin Detection System in Human Body
Authors: Abdulhadi Noor M. , Ibraheem Noor A. , Hasan Mokhtar M.
Published: January 2023

Early accurate burn depth diagnosis is crucial for selecting the appropriate clinical intervention strategies and assessing burn patient prognosis quality. However, with limited diagnostic accuracy, the current burn depth diagnosis approach still primarily relies on the empirical subjective assessment of clinicians. With the quick development of artificial intelligence technology, integration of deep learning algorithms with image analysis technology can more accurately identify and evaluate the information in medical images. The objective of the work is to detect and classify burn area in medical images using an unsupervised deep learning algorithm. The main contribution is to developing computations using one of the deep learning algorithm. To demonstrate the effectiveness of the proposed framework, experiments are performed on the benchmark to evaluate system stability. The results indicate that, the proposed system is simple and suits real life applications. The system accuracy was 75%, when compared with some of the state-of-the-art techniques.
Kapsayıcı matematik eğitimine ilişkin sınıf öğretmenlerinin uygulamaları, yeterlilikleri ve karşılaştıkları problemler
Authors: AGAÇ Gülay , ÖZTÜRK Ayşe
Published: January 2023

Bu çalışmada, kapsayıcı matematik eğitimine (KME’ye) ilişkin sınıf öğretmenlerinin uygulamalarının, yeterliliklerinin ve karşılaştıkları problemlerin incelenmesi amaçlanmıştır. Durum araştırması olan bu çalışmanın katılımcılarını 15 sınıf öğretmeni oluşturmuş olup, veriler odak grup görüşmesi ve yarı yapılandırılmış görüşme tekniğiyle toplanmıştır. Araştırma verileri içerik analizi yapılarak çözümlenmiştir. Araştırma sonuçları genel olarak değerlendirildiğinde, araştırmaya katılan sınıf öğretmenlerinin 12’sinin KME amaçlı hazırlık, öğretme-öğrenme süreci ve ölçme-değerlendirme bağlamında çeşitli çalışmalar gerçekleştirdikleri, üçünün ise herhangi bir çalışma yapmadığı görülmüştür. Ayrıca, sınıf öğretmenlerinin uygulama sürecinde KME bağlamında çeşitli problemler yaşadıkları ve biri dışında mesleki yeterlilik açısından kendilerini yeterli görmedikleri ortaya çıkmıştır. Araştırmada, KME’nin etkili hâle getirilmesi için hizmet içi eğitimlerin yapılması, materyal hazırlanması ve programda düzenlemeler yapılması gibi çeşitli önerilerde bulunulmuştur.
Cadmium and zinc accumulation behaviour of hyperaccumulator Arabidopsis halleri ssp. gemmifera in the hydroponic system
Authors: Sari Syarifah Hikmah Julinda , Chien Mei-Fang , Inoue Chihiro
Published: January 2023

Arabidopsis halleri ssp. gemmifera is classified as Cd and Zn hyperaccumulator plant, however, the disparity accumulation preferences in organs (root, stem and leaves) between cadmium and zinc seems less understandable. Therefore, this study aimed to portray accumulation behaviour toward the presence of Cd and Zn in the hydroponic method employing A. halleri ssp. gemmifera. The experiment was conducted by applying this plant using 2 and 300 µM of Cd, and 2 and 200 µM Zn, together with 20% Hoagland solution for 7 days, separately. The results showed that Zn in the medium was uptake faster than Cd. Furthermore, increasing Cd/Zn supply at the medium resulted in an increasing accumulation of Cd/Zn in the organs of the plant. In both Cd treatments, the accumulation followed the order of stem>root>leaves, indicating Cd transportation to the upper part has occurred during this period. The same accumulation preference pattern was also reported in the 200 µM Zn supply. However, at 2 µM Zn supply, Zn accumulation was mainly found in the leaves, followed by the root and stem. A. halleri ssp. gemmifera uptake Zn faster from the medium and translocate rapidly to the leaves at low-level Zn supply. Increasing Zn supply concentration might inhibit the translocation of Zn from stem to leaves. Meanwhile, regardless of Cd supply concentrations, this plant could only translocate Cd to the stem mostly within a short-time exposure period. Therefore, this study concluded that A. halleri ssp. gemmifera exhibited different accumulation responses when exposed to different Cd and Zn supply concentrations.