bluuebunny/crossref_metadata_2025 huggingface dataset:
Computational investigation of phytochemicals from Allamanda cathartica as a potent agonist of Peroxisome proliferator-activated receptor-gamma (PPARγ) for the treatment of Diabetes mellitus
Authors: Tomar Ritu , Mishra Shashank , Sahoo Jagannath , Rath Santosh Kumar
Published: April 2024

Diabetes, a chronic metabolic disease, has become a serious health problem worldwide. According to the latest data from the International Diabetes Federation (IDF), there were 451 million DM patients worldwide in 2017, and would be expected to increase to 693 million by 2045. Therefore, there is a need to develop new drug-like molecules to combat this problem. Peroxisome proliferators-activated receptors (PPARs) are ligand-inducible nuclear receptors that control many intracellular metabolic processes. PPARγ agonists can improve metabolism and reduce the side effects caused by single drugs and have become a valuable drug target for designing effective drugs for the treatment of type 2 diabetes. In the present investigation, by the application of bioactivity score prediction, molecular docking, and ADMET prediction approach, the potential and selective phytoconstituents with the highest binding affinity, and lower toxicity than reference drug rosiglitazone was gained from the curated datasets of Allamanda cathartica. Further molecular dynamics simulations were carried out to identify the favourable binding conformations when the top-scored phytoconstituents bind with the PPARγ receptors compared to the rosiglitazone. Compound AC2 interacts with the PPARγ proteins through the formation of 7 hydrogen bonds with the amino acid residues Phe282, His449, Tyr327, His323 and Ser289. The ligand was bound to the protein during the simulation since none of the complexes conformations were unstable and no unfolding or folding took place. Our results provided an approach to further design and optimize the natural product-inspired small druglike molecules as potential antidiabetic agents. The present study highlighted that the phytoconstituents of Allamanda cathartica has antidiabetic potential as PPARγ agonists that can be further explored for novel antidiabetic drug development.
The Effect of High Ownership Concentration on Tax-Motivated Income Shifting : Evidence from North Africa Multinational Groups
Authors: soltani lynda
Published: April 2024

This paper focuses on multinational corporate groups that resort to income shifting motivated by tax evasion, measuring their association with high ownership concentration. In order to test our hypothesis, our sample is composed of parent companies located in north africa as well as subsidiaries with a lower tax rate than the parent company. The model is based on natural logarithm of pre-tax profit. The results show that parent companies with a high concentration of ownership transfer income for tax avoidance purposes. The result is that governments are reducing their statutory tax rates to encourage investors to focus on high concentration companies in order to increase economic growth. This study shows that, depending on their characteristics, entrepriques can practise tax avoidance strategies, with the emphasis on high levels of ownership concentration
Causal network localization of brain stimulation targets for trait anxiety
Authors: Siddiqi Shan , Klingbeil Julian , Webler Ryan , Kratter Ian , Blumberger Daniel , Fox Michael , George Mark , Grafman Jordan , Pascual-Leone Alvaro , Pines Andrew , Richardson R. Mark , Talati Pratik , Vila-Rodriguez Fidel , Downar Jonathan , Hershey Tamara , Black Kevin
Published: April 2024

Transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS) can treat some neuropsychiatric disorders, but there is no consensus approach for identifying new targets. We localized causal circuit-based targets for anxiety that converged across multiple natural experiments. Lesions (n=451) and TMS sites (n=111) that modify anxiety mapped to a common normative brain circuit (r=0.68, p=0.01). In an independent dataset (n=300), individualized TMS site connectivity to this circuit predicted anxiety change (p=0.02). Subthalamic DBS sites overlapping the circuit caused more anxiety (n=74, p=0.006), thus demonstrating a network-level effect, as the circuit was derived without any subthalamic sites. The circuit was specific to trait versus state anxiety in datasets that measured both (p=0.003). Broadly, this illustrates a pathway for discovering novel circuit-based targets across neuropsychiatric disorders.
Factors affecting the willingness to pay for biogas digestor construction of pig farms in Champasak province Lao PDR
Authors: Fongsamouthb Salongxay , Moonphoxay Houmpheng , Phaxaisithidet Thanousinh , Sounakeovongsa Vilaphone , Homsombath Philavanh , Souvannasouk Vannasinh
Published: April 2024

This paper aims to estimate the environmental issue and policy recommendations for supporting biogas digestor construction. An environmental evaluation related to environmental protection and raising natural resources as renewable energy to persuasion policy applies to pig farms with the idea of building a biogas digestor. The main occupation of the household has a relationship in the same direction as the WTP, agricultural occupation as their main occupation, especially crop producing and feeding animals, be willing to pay more than the households that are engaged in other occupations because the households that are engaged in agricultural production have high expectations for the not only benefits producing biogas, but also high-quality compost that can be used for their crops producing as well. They are willing to pay more than others, especially in a situation where the price of chemical fertilizers is high like the current situation. The period of raising pigs (year) has a relationship in the opposite direction to the WTP, and households with increased periods of raising pigs have the opportunity to be willing to pay less with a statistical significance level of 90%. It may be because the number of pigs has a relationship in the same direction with WTP, according to the hypothesis, a household with an increase in the number of pigs in the farm has a chance to be willing to pay by 1.43% with a statistical confidence level of 99%.
A field study of manhole cover leakage
Authors: Lowe Scott
Published: April 2024

Leaking manhole covers add inflow to sanitary sewer systems. These are the most accessible components of the sewer system, and so potentially the cheapest to repair or modify, to reduce inflow. There is, however, very little data regarding manhole cover leakage available to evaluate the cost–benefit of such an approach, and there is no field data. So, a multi-year field study of inflow was conducted. Two-hundred and fifty manholes in New York City and surrounding towns were tested. A key field observation in this study was that a dust and grit seal typically built up between the cover and the rim. This seal had a big impact on leakage rates. This made testing in-situ a necessity, and the test method had to preserve this seal. Due to the presence of the dust and grit seal, approximately 80% of the manholes tested showed no leakage. A further 15% had slow leaks. Only 5% had significant leaks.
Syntheses and Spectroscopic Characterization of Selected Methyl
Quinolinylphosphonic and Quinolinylphosphinic Acids; Rationalized based on DFT
Calculation
Authors: Nycz Jacek E. , Karaush-Karmazin Nataliya , Minaev Boris , Minaeva Valentina , Małecki Jan G. , Książek Maria , Swoboda Daniel , Kusz Joachim
Published: April 2024

The quinoline derivatives arouse interest due to their broad spectrum of activity.
The phosphorus compounds under investigation, quinolinylphosphonic and -phosphinic
acids and aminophenylphosphonic and -phosphinic acids, possess potent bioactive properties,
mimicking amino acids, phosphate esters, anhydrides, or carboxylate groups in enzymes.
Despite its potential value, there is no reported example of quinolinylphosphonic or -
phosphinic acids with phosphonic or phosphinic functional groups connected directly to the
benzene ring in quinoline constitution. The selected quinoline derivatives have been synthesized
by adopting the Skraup-Doebner-Von Miller reaction. To this end, the syntheses of
aminophenylphosphonic and -phosphinic acids were conducted and afforded the target
products with high yield. All structures have been proven by the combination of NMR, IR,
MS, and HRMS techniques and were rationalized based on DFT calculation. The structures of triphenylphosphane
oxide (TPO), diphenylphosphosphinic acid (1c), (tert-butyl)phenylphosphinic acid (1d) and
bis(3-nitrophenyl)phosphinic acid (2c) were determined by single-crystal X-ray diffraction measurements. The
Hirshfeld surface analyses for 1c, 1d and 2c were performed to analyze the intermolecular interactions in their
crystal structures. According to our findings, the presence of numerous intermolecular PO•••H, NO•••H, and
CH•••O contacts stabilizes the crystal structures. The NO•••H interactions manifest in the IR spectrum of 2c
crystal as a narrow band with a maximum at 3088 cm-1. The PO•••H intermolecular interactions are attributed to
a weak experimental band at 1288 cm-1.
Heroin and its Effects on the Brain
Authors: Krishnan Jayalakshmi
Published: April 2024

As per the Drug Enforcement Administration (DEA) and the Controlled
Substances Act (CSA) reports, heroin is a Schedule I drug. Heroin causes addiction to
the brain like any other addictive substance. Heroin addiction has both long-term and
short-term effects on the body. The brain has natural opioid receptors. Heroin is a
synthetic opioid. When taken regularly, the brain stops making its own natural opioids.
This affects the pain/reward system and causes withdrawal symptoms in patients.
Heroin addiction damages the brain's reward system and breathing. Less breathing
causes less oxygen supply to the brain. There are reports that state that dementia-like
situation is created in the brain due to heroin abuse. Heroin lipophilicity allows the
entry of it into the Blood Brain Barrier. μ-opioid receptors (MOR), causing the
addictive effects of the heroin in the brain. Dementia symptoms, memory issues, and
mental health changes like depression or anxiety are the symptoms that are caused by
heroin abuse. Both individual and environmental factors influence a person's ability to
abuse heroinanopioid which provides intense feelings of pleasure.
Development of a U.S./U.K. Collaborative Online International Learning (COIL) partnership for undergraduate education in public health
Authors: Versnik Nowak Amy , Gray Marzell , Omodara Damilola , Gibson Linda
Published: April 2024

Preparing future public health (U.S.) or health and social care (U.K.) professionals for international settings is imperative in today’s higher education landscape. Collaborative Online International Learning (COIL) is an innovative form of virtual exchange (VE) that provides students with international experience, cultural competence, and an understanding of global healthcare needs. This practice report summarizes how two universities in the U.S. and U.K. co-developed a COIL unit for their public health and health and social care students to learn about international healthcare systems. Public health faculty used SUNY COIL planning strategies and backward course design to guide the planning of the COIL unit. The learning processes and outcomes were designed to support program and campus learning outcomes that align with domain areas required by the Council on Education for Public Health. The planning process, curriculum, and technology used for the COIL unit are outlined. Evaluation of the unit included achieving student learning outcomes at the course, program, and campus levels; changes in intercultural awareness based on the Intercultural Knowledge and Competence VALUE Rubric; benefits to students, research assistants, and faculty; and alignment with the qualities of VE.
Using the Cuckoo Optimization to Initialize the Harmony Memory in Harmony Search Algorithm to Find New Hybrid (CSHS) Algorithm
Authors: Hameed Fariaa , Tariq Kanar , Hasan Harith , Johni Riyam
Published: April 2024

The current paper seeks to present a hybrid harmony search algorithm, using CS and HS. The proposed algorithm takes advantage of using a method to initialize the harmony memory (HM) with the help of the cuckoo search optimization algorithm. The HS algorithm is inspired by the method used by musicians to create and enhance harmony in music. It follows 3 main principles of pitch adjustment (PA), HM consideration (HMC), and random selection (RS). The performance of HS can be affected by its poor accuracy in optimization and speed of convergence, 2 main issues with it. However, to improve the HS algorithm, Cuckoo search can be used as it can do a local search using one parameter only, other than the size of the population, making it work more efficiently. This current method has been tested for its validity and efficiency in performance by being implemented on many international standard optimization problems. The results confirm the fact that the performance of the currently proposed algorithm is better and more efficient in finding solutions compared to HS and other algorithms.
An Infrastructure Framework for Remote Patient Monitoring Interventions and Research
Authors: Claggett Jennifer , Petter Stacie , Joshi Amol , Ponzio Todd , Kirkendall Eric
Published: April 2024

Remote patient monitoring (RPM) enables clinicians to maintain and adjust their patients’ plan of care by using remotely gathered data, such as vital signs, to proactively make medical decisions about a patient’s care. RPM interventions have been touted as a means to improve patient care and well-being while reducing costs and resource needs within the health care ecosystem. However, multiple interworking components must be successfully implemented for an RPM intervention to yield the desired outcomes, and the design and key driver of each component can vary depending on the medical context. This viewpoint and perspective paper presents a 4-component RPM infrastructure framework based on a synthesis of existing literature and practice related to RPM. Specifically, these components are identified and considered: (1) data collection, (2) data transmission and storage, (3) data analysis, and (4) information presentation. Interaction points to consider between components include transmission, interoperability, accessibility, workflow integration, and transparency. Within each of the 4 components, questions affecting research and practice emerge that can affect the outcomes of RPM interventions. This framework provides a holistic perspective of the technologies involved in RPM interventions and how these core elements interact to provide an appropriate infrastructure for deploying RPM in health systems. Further, it provides a common vocabulary to compare and contrast RPM solutions across health contexts and may stimulate new research and intervention opportunities.
Analysis on the Path to Improve College Students' Innovation Ability
Authors: Guan Lijie
Published: April 2024

The core elements of innovation or creativity mainly include creative thinking and creative personality. Universities should start from the perspectives of collaborative participation, service and publicity, establish a sound innovation education mechanism, link up professional teaching, develop characteristic entrepreneurship and innovation courses, build diversified entrepreneurship and innovation practice platforms, and hold entrepreneurship and innovation competitions, so as to promote college students to accumulate knowledge, skills and experience in innovation and entrepreneurship in practice.
Polar Question Particle Ke in Bagri
Authors: Syopat Syopat
Published: April 2024

The aim of this paper is to provide an account for the unique properties of the polar question particle (PQP) Ke in Bagri. Being a dialect of Hindi, this PQP is similar to its Hindi counterpart Kyaa in many aspects: optional occurrence in polar (Yes/No) questions, selectiveness in embedded polar questions, information structural effects. However, unlike Hindi, it is restricted to only polar Y/N questions and cannot occur in a clause-initial position, similar to PQP Ki in Bangla and Odia. Since Ke in Bagri meets all the necessary conditions explicitly laid out in Bhatt and Dayal (2018), we argue that this lexical item qualifies as a PQP residing in ForceP and has a presuppositional requirement that its complement must be a singleton-set question. Moreover, Ke is enclitic in nature requiring some phonological element to be present to its left.
Harnessing Emotional Intelligence for Music Curation in Recommendation Systems
Authors: Sruthi Dr.
Published: April 2024

Abstract- When an individual decides the music he or she wants to listen to from a huge collection of already-existing options, sometimes it might get confusing. Diverse maneuvers have been executed for music, pride and food, and shopping based on user mood available, but there is no centrally managed network for all. The objective behind the technology of our music recommendation system is to give user-fitted recommendations to customers. The facial expression/user emotion analysis may a way to rectify defects in the current emotional or mental status of a user. When it comes to music and videos, this is the one area where there is a considerably large avenue for predictions based on customer tastes and previous records. This is a common thing that you've probably heard: that people often use facial expressions to be more direct about what they are really saying and the situation they are in. More than 60% of users agree with the sentiment that it will at some point become so difficult for them to determine which video they should play because quantity of videos in their library is really huge. Through the modelling of a robot dedicated to making recommendations about music to a user, it can facilitate the decision-making of which music one should be listening to and, thereby, lower the stress levels of the user. The user would not need to spend time on music searching or looking up suitable songs, as the best song paired with the user’s mood status would be successfully detected and immediately recommended to him/her by the application. The picture of the user is delivered through the camera incorporated into it. The picture of the user is taken, and then song is displayed on the screen in accordance with the mood or emotion of the user from their playlist, which matches the needs of the user.
Classification of Embryos Using Microscopic Pictures
Authors: Shruthi Dr. P.
Published: April 2024

Abstract: This study focuses on classifying the microscopic images of embryo by using DL neural networks including Mobilenet that captures the crucial patterns in the images and classify whether the Embryo is Good or Bad for In-Vitro Fertilization (IVF). The paper introduces an enhanced DL-based approach for recognizing patterns within images and adjusting each input image to meet specified normalization criteria, as normalization plays a crucial role in ensuring consistency, comparability across data sets. The dataset consists of 1079 embryos from which 239 microscopy images were utilized to validate the proposed method.
Classical analogue of quantum superdense coding and communication advantage of a single quantum system
Authors: Patra Ram Krishna , Naik Sahil Gopalkrishna , Lobo Edwin Peter , Sen Samrat , Guha Tamal , Bhattacharya Some Sankar , Alimuddin Mir , Banik Manik
Published: April 2024

We analyze utility of communication channels in absence of any short of quantum or classical correlation shared between the sender and the receiver. To this aim, we propose a class of two-party communication games, and show that the games cannot be won given a noiseless 1-bit classical channel from the sender to the receiver. Interestingly, the goal can be perfectly achieved if the channel is assisted with classical shared randomness. This resembles an advantage similar to the quantum superdense coding phenomenon where pre-shared entanglement can enhance the communication utility of a perfect quantum communication line. Quite surprisingly, we show that a qubit communication without any assistance of classical shared randomness can achieve the goal, and hence establishes a novel quantum advantage in the simplest communication scenario. In pursuit of a deeper origin of this advantage, we show that an advantageous quantum strategy must invoke quantum interference both at the encoding step by the sender and at the decoding step by the receiver. We also study communication utility of a class of non-classical toy systems described by symmetric polygonal state spaces. We come up with communication tasks that can be achieved neither with 1-bit of classical communication nor by communicating a polygon system, whereas 1-qubit communication yields a perfect strategy, establishing quantum advantage over them. To this end, we show that the quantum advantages are robust against imperfect encodings-decodings, making the protocols implementable with presently available quantum technologies.
Hub Parameters of Hypergraph
Authors: Chandrasekar Nandhini , Myithili K. K.
Published: April 2024

A hypergraph is an extension of a graph in which one edge can connect any number of vertices. In contrary, an edge connects exactly two vertices in a graph.In this paper we introduce hub-hyperpath, hubset and hubnumber of a hypergraph. Also we defined the hubnumber of a different types of hypergraphs and analyze some of its properties. Then the hub number of a hypergraph is compared with its dual hypergraph. Hubset can be useful for various tasks, such as targeted marketing and social networks. Additionally, finding the hub number of a graph is useful in network security, as it helps in identifying nodes that, if compromised, could have a significant impact on the overall network.
The Riemann problem for the main model cases of the Euler-Poisson equations
Authors: Gargyants L. V. , Rozanova O. S. , Turzynsky M. K.
Published: April 2024

In this paper, we construct a solution to the Riemann problem for an inhomogeneous nonstrictly hyperbolic system of two equations, which is a corollary of the Euler-Poisson equations without pressure [9]. These equations can be considered for the cases of attractive and repulsive forces as well as for the cases of zero and nonzero underlying density background. The solution to the Riemann problem for each case is nonstandard and contains a delta-shaped singularity in the density component. In [16], solutions were constructed for the combination corresponding to the cold plasma model (repulsive force and nonzero background density). In this paper, we consider the three remaining cases.
Averaging method for problems on quasiclassical asymptotics
Authors: Dobrokhotov S. Yu. , Nazaikinskii V. E.
Published: April 2024

The averaging method is developed for operators with rapidly oscillating coefficients, intended for use in problems of quasiclassical asymptotics and not assuming a periodic structure of coefficient oscillations. Algebras of locally averaged functions are studied, an averaging theorem for differential operators of general form is proved, and some features of the method are illustrated using the example of the wave equation.
Coercive estimates for multilayer degenerate di erential operators
Authors: Kazaryan G. G.
Published: April 2024

We obtain the conditions under which a given multilayer differential operator \(P(D)\) (polynomial \(P(\xi)\)) is more powerful than operator \(Q(D)\) (polynomial \(Q(\xi)\)). This is used to obtain estimates of monomials, which, in turn, using the theory of Fourier multipliers, is used to obtain coercive estimates of derivatives of functions through the differential operator \(P(D)\) applied to these functions.
Barodontalgia during hyperbaric oxygen therapy of an 8-year-old male: A case report
Authors:   Marmara University, Faculty of Dentistry, Department of Oral and Maxillofacial Radiology, Istanbul, Turkey, Öçbe, DDS Melisa , Sümen, MD Selin Gamze ,   University of Health Sciences, Kartal Dr. Lutfi Kirdar City Hospital, Department of Underwater and Hyperbaric Medicine, Istanbul, Turkey, Altun, DDS Büşra Dilara ,   Marmara University, Faculty of Dentistry, Department of Oral and Maxillofacial Radiology, Istanbul, Turkey, Dumlu, DDS Asım ,   Marmara University, Faculty of Dentistry, Department of Oral and Maxillofacial Radiology, Istanbul, Turkey
Published: April 2024

Barodontalgia, barometric pressure-induced dental pain, may occur during hyperbaric oxygen (HBO2 ) therapy due to pressure changes. This case report presents an 8-year-old male patient with barodontalgia. The patient declared a severe toothache during HBO2 therapy. The diving medicine specialist referred the patient to the dental clinician immediately. On clinical examination, the pain was thought to be caused by caries lesions of the deciduous teeth in the left maxillary molar region. Tooth extraction was suggested. After extraction, the patient continued hyperbaric oxygen therapy sessions without any pain. The patient was recommended for an intraoral and radiographic examination session one week after the extraction. In conclusion, caries lesions and faulty restorations should be examined before hyperbaric oxygen therapy sessions. Even though barodontalgia is a rare phenomenon, dental examination is essential to avoid these kinds of pain-related complications. All carious lesions and defective restorations must be treated, if necessary. Removal of faulty restorations and management of inflammation as part of the treatment is suggested before exposure to pressure changes.
Health Insurance Literacy: Bridging the gap between Financial Knowledge and Purchase Intention
Authors: Supriya M.Lalitha , PJyothi *
Published: April 2024

It is a matter of serious concern that in spite of having the financial
capacity, a significant portion (30%) of India’s population referred to
as the ‘Missing Middle’- lacks health insurance due to limited awareness
[1](#ref-0001). The present research tries to understand how health
insurance literacy influences purchase intentions and how financial
knowledge contributes to this relationship. This study aimed to explore
and understand the mediating role of health insurance literacy in the
relationship between an individual’s financial knowledge and their
intention to purchase health insurance. Data was collected through a
cross-sectional survey using a structured questionnaire and analysed
using the PLS-SEM technique with SmartPLS software. The results are in
the expected direction and the findings confirm that an individual’s
subjective financial knowledge does affect their purchase intention
which is mediated by health insurance literacy. These insights have
implications for stakeholders in the health insurance industry as well
as policy makers, suggesting the need for targeted educational efforts
aimed at different and distinct population segments.
Extensive and Progressive Cerebral Infarction Associated with Mycoplasma pneumoniae Infection. A Case Report and Literature Review
Authors: Ni Shijia , Che Siyi , Cai Jinhua
Published: April 2024

Mycoplasma pneumoniae (MP) is one of the most common respiratory
pathogens causing respiratory infection in children, especially in those
above 5 years old. Although rare, cerebral infarction is the most severe
neurological complication of MP infection and could be fatal. Herein, we
report a case of extensive and progressive acute cerebral infarction
associated with MP infection, which not only received medical treatment
but also underwent a decompressive craniectomy. Computed tomography
angiography (CTA) and magnetic resonance angiography (MRA) revealed
occlusion of the left internal carotid artery, left anterior cerebral
artery, and middle cerebral artery. In order to better understand the
relationships between MP infection and cerebral infarction both on
clinical and radiological perspectives, literature of cerebral
infarction associated with MP infection were searched and reviewed.
ICD in Cardiac Sarcoidosis: Variables associated with appropriate therapy, inappropriate therapy, and device complications
Authors: Mactaggart Sebastian , Ahmed Raheel
Published: April 2024

Introduction: Those with cardiac sarcoidosis (CS) are at risk
of sudden cardiac death (SCD), which may be prevented using an
implantable cardioverter defibrillator (ICD). There is limited data
available that follows the post-procedural outcomes of patients with
cardiac sarcoidosis (CS) who have had an ICD implanted. Areas
Covered: This review will highlight studies that focus on both
appropriate and inappropriate therapies in those with an ICD, as well as
device complications in this group. There were several variables
inclusive of age, gender, ventricular characteristics and findings on
cardiac imaging that were investigated and discussed as influencing
factors in predicting appropriate and inappropriate therapies.
Conclusions: Adverse events in those with an ICD and CS were
minimally reported in the literature. Individuals diagnosed with CS are
at high risk of ventricular arrhythmia, with comparable rates of
appropriate therapy but higher incidence of side effects and
inappropriate therapy. The younger average age of CS patients in
comparison to other ICD cohorts warrants the need for further,
large-scale, prospective trials with periodic interim follow-ups focused
on those with this condition.
IT-ENABLED WGCNA FOR CRITICAL GENE MODULE MAPPING AND THERAPY OPTIMIZATION: ADVANCING LEUKEMIA CARE
Authors: Kapçiu Rinela
Published: April 2024

Acquiring a profound comprehension of the complex correlation between genes is essential for progressing treatment and diagnostics in acute leukemia research. This work utilizes WGCNA to analyze the gene expression data obtained from 72 patients diagnosed with acute leukemia. This approach has not been widely employed in this particular setting previously. Our first objective was to identify essential gene modules and core genes that could offer a novel insight into the fundamental causes of the disease. To ensure the precision of the gene expression data, a thorough pre-processing is carried out, which includes normalization and quality control techniques. The WGCNA technique produces a gene co-expression network that targets explicitly differentially expressed genes (DEGs). This network is designed primarily to exploit pairwise correlations, as the underlying data is meant to create such a network. The modules identified via hierarchical clustering are assigned distinct colors to aid in recognizing gene expression patterns and associations that may not be readily apparent when examining individual genes in isolation. An essential component of our research involved identifying pivotal genes inside these modules using several centrality metrics, including degree, closeness, and betweenness centralities. These genes are suspected to have a crucial role in starting and progressing acute leukemia. We must mention that genes such as M91438_at and S82362_s_at came out as significant, in line with their centrality in the network analysis. However, it is privileged that these results hold a promise for further validation. The study throws open trails for future research, especially in experimental validation of these genes. These findings indeed have the potential to contribute to the development of targeted therapies and improvement in diagnostic methods, resulting in better patient outcomes in acute leukemia. This study also highlights the applicability of WGCNA towards unraveling leukemia's genomics, underscoring the continued exploration in this critical area of medical research.
Tick-borne infections in the Leningrad oblast: incidence and seroprevalence
Authors: Karmokov I. A. , Riabiko E. G. , Baimova R. R. , Buts L. V. , Khalilov E. S. , Grechishkina D. I. , Lyzenko I. S. , Bachinin I. A. , Tokarevich N. K.
Published: April 2024

The study’s objective was to reveal trends in infections transmitted by ixodes ticks epidemic processes and the level of seroprevalence of the population to the tick-borne encephalitis virus, Borrelia burgdorferi sensu lato, Coxiella burnetii, Anaplasma phagocytophilum and Ehrlichia chaffeensis/ E. muris in the Leningrad Oblast.

Materials and methods. A retrospective epidemiological analysis of the tick-bite incidence rate, the ixodic tick-borne borreliosis, tick-borne encephalitis, Q fever, human granulocytic anaplasmosis and human monocytic ehrlichiosis incidence rates, as well as vaccination against tick-borne encephalitis of the population of the Leningrad Oblast in 20112020. The official data of the tick-bite incidence rate, infections transmitted by ixodes ticks incidence rates and vaccination of the population was taken from the forms of federal statistical observation No. 2 and No. 5. Blood was sampled in 2019-2020 from randomly selected donors. Blood serum samples were examined by enzyme-linked immunosorbent assay for the presence of IgG antibodies to the pathogens of the studied infections using commercial test systems according to the manufacturer’s instructions.

Results. In the Leningrad Oblast, in 2011-2020, there was a downward trend in the tick-bite incidence rate, as well as in the incidence rates of infections transmitted by ixodic ticks. The long-term average tick bite incidence rate was 369.0. The long-term average incidence rate of ixodic tick–borne borreliosis was 4.1; tick–borne encephalitis was 1.4; Q fever was 0.02. During the analyzed period, no cases of human granulocytic anaplasmosis and human monocytic ehrlichiosis were reported. The seroprevalence to tick-borne encephalitis virus was 1.7%; to B. burgdorferi s. l. – 3.7%; to C. burnetii – 1.8%; to A. phagocytophilum – 1.0%; to E. chaffeensis/ E.muris – 3.2%.

Conclusion. The results obtained indicate the existence of active natural foci of infections transmitted by ixodes ticks, fairly frequent contact of the residents with these foci, and possible significant hypodiagnosis of these infections in the Leningrad Oblast.
POLA PEWARISAN TARI COKEK SIPATMO DIKAMPUNG WISATA BUDAYA TEHYAN KOTA TANGERANG
Authors: Toyibah Lala Halalan , Permanasari Alis Triena , Hadiyatno Hadiyatno
Published: April 2024

Penelitian ini dilatarbelakangi Tarian Cokek Sipatmo yang merupakan hasil dari akulturasi budaya Betawi dan Tionghoa yang didukung oleh pola pewarisan dalam proses perkembanganya. Adapun  tujuan penelitian diantaranya adalah untuk menggali informasi mengenai pola pewarisan Tari Cokek Sipatmo dan faktor yang mempengaruhi pola pewarisan Tari Cokek Sipatmo. Metode penelitian yang digunakan yaitu metode kualitatif deskriptif dengan teknik pengumpulan data melalui observasi, wawancara, dan dokumentasi, serta analisis data dilakukan dengan reduksi data, penyajian data, dan menginterpretasikan informasi yang diperoleh. Berdasarkan hasil penelitian didapatkan bahwa Tari Cokek Sipatmo melalui pola pewarisan diagonal dengan melibatkan dukungan pewarisan dari lingkungan sosial di Kampung Wisata Budaya Tehyan dan Lembaga Pendidikan yang diterapkan sebagai materi pada ekstrakulikuler di SMK Kristen Gracia. Adapun faktor yang mempengaruhi pola pewarisan meliputi motivasi prestasi, motivasi afiliasi, motivasi kompetensi, motivasi kekuasaan dan dukungan dari lingkungan sekitar Kampung Wisata Budaya Tehyan, kebijakan pemerintah serta aspek sosial budaya dan ekonomi, sehingga Tari Cokek Sipatmo tetap berkembang sampai saat ini
Kooperatywy mieszkaniowe jako innowacyjne rozwiązanie na polskim rynku nieruchomości
Authors:   Uniwersytet Ekonomiczny w Krakowie, Badura Ewelina
Published: April 2024

The first works on the act on housing cooperatives appeared in mid-2019. Work on the project of the then Ministry of Investment and Development was interrupted by the election calendar. The second attempt took place in 2020 (draft act of April 9, 2020 on housing cooperatives). The project is part of the concept contained in the National Housing Program. During the consultations, a number of comments and opinions were received. According to, inter alia, The original draft of the Government Legislation Center contained the statutory privilege of cooperatives over other entities operating in the field of housing construction. For this reason, it was necessary to prepare a new draft act on housing cooperatives and the rules for the sale of real estate belonging to the municipal real estate resource in order to support the implementation of housing investments, which appeared on July 21, 2021. on a voluntary association of people who pursue their housing goals. The project relates not only to housing cooperatives, but also to newly established housing cooperatives.
Různé aspekty fenoménu moci
Authors:   Právnická fakulta Univerzity Karlovy, Hodek Viktor
Published: April 2024

In my contribution, I focus attention on the phenomenon of power, which is the focus of my dissertation research on the topic: „The power of judicial power“. It can be safely said that the very word „POWER“ is surrounded by a veil of mystery and has a magical touch and evokes various feelings. However, this word is often mentioned rather in pejorative connotations. However, it is hard for anyone to deny that power has its „dangerous attraction“. In general, power as a social category is associated with a certain differentiation, hierarchization of society, expresses superiority and subordination. Bertrand Russel (1872–1970), an English mathematician and philosopher, considered power to be „a fundamental concept of the social sciences, just as energy is a fundamental concept of physics“. This phenomenon is therefore investigated by a number of social sciences. In my contribution, at least in theses and quotes, I will try to draw attention to the views of these sciences. The views of philosophy, sociology, political science and, of course, law will be discussed gradually, but also in a connected manner. Unfortunately, due to the scope of the contribution, it will not be possible to discuss psychological, economic, or theological aspects.
Imunita a indemnita ústavných činiteľov
Authors:   Paneurópska vysoká škola v Bratislave, Kostelník Erik
Published: April 2024

Contribution analyzes and approximates the development of the institution of immunity and indemnity of constitutional officials in the territorial conditions of the Slovak Republic, its current significance and comparison of the legal arrangement with the most closely related legal order of the Czech Republic.
The problem of sovereignty according to Hans Kelsen and Luigi Ferrajoli
Authors:   University of Padua, Department of Public, International and European Law, Daldoss Ivan
Published: April 2024

This contribution deals with the theme of ‘sovereignty’, especially state sovereignty, as a problematic concept that, from legal modernity onwards, falls into crisis and determines multiple aporias. According to the theoretical constructions of the two authors here considered in a diachronic key, Kelsen and Ferrajoli, it should be overcome in favour of an internationalist dimension of law, which can effectively guarantee the protection of fundamental rights and peace, thus approaching the horizon that Kant outlined at the end of the 18th century. This contribution will therefore set out several reasons why such a shift is desirable.
Periodická tlač
Authors:   Univerzita Komenského v Bratislave, Právnická fakulta, Munk Rastislav
Published: April 2024

Act. no. 265/2022 Coll. on Press Publishers and the Register in the Field of Media and Audiovisual and on Amendments and addition of certain Acts (Publications Act) with effect from August, 1 2022 constitutes a long-awaited shift in the legislation in the field of periodicals in the Slovak Republic. While for a long time only printed matter of periodicals or other press, i.e., media in printed form, was considered periodicals, the Publications Act changed it. The aim of the article was to analyze the most fundamental shift in the field of periodicals in the Slovak Republic which occurred with the adoption of the Publications Act. The article directed attention exclusively to periodicals which understood press in its literal meaning i.e., in the Slovak republic periodical press or other press were for a long-time considered periodicals only if printed. In connection with the adoption of the Publications Act, there was a significant shift, as the Publications Act no longer defines periodical press but introduces new terms such as publication, periodical publication including scientific and professional periodical publication. The basic goal was to analyze the most fundamental shift in the field of periodicals according to the Press Act and to introduce a new legal regulation of periodical publications according to the Publications Act.
Rodový audit ako nástroj boja proti rozdieľom v odmeňovaní Islande a v Slovenskej republike
Authors:   Právnická fakulta Univerzity Komenského v Bratislave, Nevická Denisa
Published: April 2024

The topic of gender audits in labor law is relatively heterogeneous in the European states. While in Iceland, gender audits are a common part of labor law culture, in the Slovak Republic it is a new phenomenon that has no basis in legislation. In the article, the author deals with the essentials of a gender audit as well as its use in labor relations in order to achieve equality in payment and a way to fight pay gap. Furthermore, the author analyzes the approach to gender audits in Iceland and the Slovak republic and points out their advantages as well as pitfalls. In the author’s opinion a gender audit is an effective tool promoting gender equality in the workplace and it should be one of the decisive criteria when providing subsidies from public funds, hence “forcing” the employers to ensure gender equality at workplace.
Povinné pojištění jako možné řešení odpovědnosti za činnost autonomních strojů
Authors:   Právnická fakulta Univerzity Karlovy, Rosůlek Jan
Published: April 2024

Today‘s regulation of liability for damage caused by an autonomous machine appears inadequate for the future. One of the variants discussed is the mandatory insurance of the autonomous machine. However, the question of who would be the person obliged to insure the autonomous machine needs to be resolved. In the case of tangible products, the owner of the autonomous system should be the liable person. Furthermore, a more appropriate solution seems to be to supplement the insurance with a guarantee fund. There is then a broader discussion of how the guarantee fund should be created and who should manage it.
Právní konceptualismus jako obecná teorie práva a jako společný jmenovatel pro další teorie
Authors:   Katedra evropského hospodářského práva Právnické a správní fakulty Univerzity v Lodži, Rzymowski Jakub
Published: April 2024

Legal conceptualism is my original theory that explains the validity of law and answers the question of what the law is. The theory is based on the theory of universals as defined by Aristotle and Piotr Abelard. In my considerations, I also use the findings of the Czech ontologist, prof. Zbynek Fisher (Egon Bondy). The theory is ontological in nature. The basis of the theory is the concept that the rights that people are entitled to exist primarily in the mind of a person. These rights are at the same time the characteristics of the persons to whom they are entitled. Rights exist insofar as they manifest themselves in the specific rights of specific people. The theory was not so conceived, but it can serve as a common denominator for many known theories, for normativism, for Hart’s theory, for the theory of the law of nature, for positivist theories.
Vývoj obranných prostředků proti nařízení izolace nebo karanténního opatření v rámci epidemie onemocnění COVID-19
Authors:   Katedra správního práva a finančního práva Právnické fakulty Univerzity Palackého v Olomouci, Smrčková Gabriela
Published: April 2024

Public health protection authorities are authorized to order isolations or quarantine measures for specific persons in accordance with Public Health Protection Act in justified cases. Such a procedure is regulated by The Administrative Code which, especially by those legal provisions relating to the issuing of decisions. On the basis of § 8a of The Pandemic Act, which is lex specialis to the Public Health Protection Act public health protection authorities are eligible to order the isolations or the quarantine measures arising from the disease Covid-19 as well. but in the form of an intervention, not in a form of a legal decision. Moreover § 8a of The Pandemic Act expressly excludes the application of the second and third part of The Administrative Code when ordering the isolations or the quarantine measure. In fact determining this legal form of that activity of the public health protection authorities is crucial for possible subsequent legal protection.
Konanie o vydaní súhlasu s inšpekciou
Authors:   Univerzita Pavla Jozefa Šafárika v Košiciach, Právnická fakulta, Katedra občianskeho práva, Sudzina Milan
Published: April 2024

The article analyzes the issue of issuing a decision giving consent to the inspection of buildings, premises or means of transport, which may be carried out by the Commission or the Antimonopoly Office of the Slovak Republic. The purpose of the inspection is to provide evidence that a person has acted unlawfully in competition and that this evidence is intended to prove that person‘s liability. The procedure for issuing the consent to the inspection is regulated in Act no. 162/2015 Coll. Administrative Procedure Code as amended.
Důsledky nelegální práce v oblasti ochrany zdraví cizinců
Authors:   University of West Bohemia, Špatenková Renata
Published: April 2024

The article deals with the performance of illegal work by foreigners and focuses on preventive and follow-up protection of health at work. During the performance of illegal work, the elements of protection can be fundamentally affected, which brings a number of negative consequences for foreigners. The article aims to highlight these consequences. The article deals in detail with the causes of illegal work and its legal regulation in the legal system of the Czech Republic. In particular, the reduced legal protection of the employee’s position as a weaker party to the contract is highlighted in the context of the lack of preventive health protection. The article also discusses work-related accidents and the most serious consequences for foreigners.
Slovenská republika ako právny štát s ohľadom na garanciu ľudských práv
Authors:   Univerzita Mateja Bela v Banskej Bystrici, Právnická fakulta, Václavová Veronika
Published: April 2024

In the contribution we consider the question whether the Slovak Republic really fulfills all the attributes of the rule of law, which it is considered to be in accordance with the Constitution of the Slovak Republic. The article discusses the issue from the point of view of the guarantee of human rights; it is concretized on the rights of persons, or same-sex couples. The legal recognition and creation of a legal union of same-sex couples is an important human rights issue resolved within the framework of the right to private and family life, which is guaranteed by Art. 8 of the Convention on the Protection of Human Rights and Fundamental Freedoms. We are of the opinion that the legal absence of recognition of the cohabitation of same-sex couples does not respect the human rights obligations of the Slovak Republic. We believe that as long as a certain right is granted to the majority, it should be a certainty for all, otherwise there is discrimination and at the same time disrespect for the codes that guarantee this. At the same time, discrimination against same-sex couples contradicts the declared model of a free and democratic society.