bluuebunny/crossref_metadata_2025 huggingface dataset:
Thiazides Attenuate Insulin Secretion Through Inhibition of Mitochondrial Carbonic Anhydrase 5b in β-Islet Cells in Mice
Authors: Kucharczyk Patrycja , Albano Giuseppe , Deisl Christine , Ho Tin Manh , Bargagli Matteo , Anderegg Manuel , Wueest Stephan , Konrad Daniel , Fuster Daniel G.
Published: March 2023

Significance Statement

Thiazide diuretics (thiazides) are among the most widely prescribed drugs worldwide, but their use is associated with glucose intolerance and new-onset diabetes mellitus. The molecular mechanisms remain elusive. Our study reveals that thiazides attenuate insulin secretion through inhibition of the mitochondrial carbonic anhydrase isoform 5b (CA5b) in pancreatic β cells. We furthermore discovered that pancreatic β cells express only one functional carbonic anhydrase isoform, CA5b, which is critical in replenishing oxaloacetate in the mitochondrial tricarboxylic acid (TCA) cycle (anaplerosis). These findings explain the mechanism for thiazide-induced glucose intolerance and reveal a fundamental role of CA5b in TCA cycle anaplerosis and insulin secretion in β cells.

Background

Thiazide diuretics are associated with glucose intolerance and new-onset diabetes mellitus. Previous studies demonstrated that thiazides attenuate insulin secretion, but the molecular mechanisms remain elusive. We hypothesized that thiazides attenuate insulin secretion via one of the known molecular thiazide targets in β cells.

Methods

We performed static insulin secretion experiments with islets of wild-type, Sodium/chloride co-transporter (NCC) (SLC12A3), and sodium-driven chloride/bicarbonate exchanger (NDCBE) (SLC4A8) knock-out (KO) mice and with murine Min6 cells with individual knockdown of carbonic anhydrase (CA) isoforms to identify the molecular target of thiazides in β cells. CA isoform 5b (CA5b) KO mice were then used to assess the role of the putative thiazide target CA5b in β-cell function and in mediating thiazide sensitivity in vitro and in vivo.

Results

Thiazides inhibited glucose- and sulfonylurea-stimulated insulin secretion in islets and Min6 cells at pharmacologically relevant concentrations. Inhibition of insulin secretion by thiazides was CO2/HCO3
−-dependent, not additive to unselective CA inhibition with acetazolamide, and independent of extracellular potassium. By contrast, insulin secretion was unaltered in islets of mice lacking the known molecular thiazide targets NCC or NDCBE. CA expression profiling with subsequent knockdown of individual CA isoforms suggested mitochondrial CA5b as a molecular target. In support of these findings, thiazides significantly attenuated Krebs cycle anaplerosis through reduction of mitochondrial oxaloacetate synthesis. CA5b KO mice were resistant to thiazide-induced glucose intolerance, and thiazides did not alter insulin secretion in CA5b KO islets.

Conclusions

Thiazides attenuate insulin secretion via inhibition of the mitochondrial CA5b isoform in β cells of mice.
Tendencias y dilemas del contexto actual hacia la construcción de una mirada prospectiva
Authors: LI Bonilla Federico , Coto Moya Luís Guillermo
Published: March 2023

La sociedad contemporánea está experimentado cambios de múltiple variedad; la comprensión de diferentes fenómenos sociales, obliga a la construcción de nuevos referentes de conocimiento, que ayuden a descifrar la dimensión, alcance y profundidad de los cambios sociales.

Para el estudio riguroso de los fenómenos sociales, se requiere de la búsqueda y construcción de nuevas bases conceptuales y metodológicas, así como de la observación aguda y crítica por parte de los científicos de la práctica social, que permita la generación de nuevas fuentes de conocimiento.

En este ámbito toma importancia evaluar el rol de un actor estratégico en la sociedad contemporánea; el cooperativismo representa un sector socioempresarial con presencia de casi un siglo de historia contemporánea, en la mayoría de los países de América Latina.

Una de las áreas, entre otras, que viene experimentando cambios importantes en el nuevo contexto, es lo referido al mundo de las organizaciones; desde una concepción en sus inicios, de carácter “bipolar”, que definía las empresas como públicas y privadas, hasta una nueva realidad, donde aparecen nuevas organizaciones que deambulan entre lo público y lo privado, entre lo social y lo particular, entre la propiedad pública y la propiedad privada, entre la democracia participativa y representativa, entre los intereses privados y los intereses colectivos.

Es en este marco que aparecen las organizaciones de la economía social solidaria, un concepto que resulta tan amplio como discreto, concreto y algunas veces difuso, con identidades, naturaleza y límites poco conocidos, donde proliferan una diversa gama de valoraciones y apreciaciones sobre su naturaleza, así como de la contribución de éstas a la sociedad.
La economía social y solidaria: Propuesta válida en los territorios
Authors: Cediel Morales Hans ,   Universidad Cooperativa de Colombia, Rodríguez Espinosa Néstor Alfonso ,   REDUNICOSOL, Valencia Velásquez Amanda Vanessa ,   Universidad Cooperativa de Colombia, Noriega Navarro Alicia ,   Universidad Cooperativa de Colombia, González Ulloa Paola Andrea ,   Universidad Cooperativa de Colombia, Jiménez Solanlly ,   Universidad Cooperativa de Colombia, Pacheco Pérez Camilo Ernesto ,   Universidad Cooperativa de Colombia, Galvis-Gómez Alba Lucía ,   Universidad Cooperativa de Colombia, Pérez Villa Pastor Emilio ,   Universidad Cooperativa de Colombia, Uribe Castrillón Víctor Hugo ,   Universidad Cooperativa de Colombia, Muñoz Navarro Óscar Diego ,   Universidad Cooperativa de Colombia, Cordero Espitia Leidys ,   Universidad Cooperativa de Colombia, Hernández Conde Sol María ,   Universidad Cooperativa de Colombia, Arteaga López Sebastián ,   Universidad Cooperativa de Colombia, Esteban Regino Edna Margarita ,   Universidad Cooperativa de Colombia
Published: March 2023

¿Cuáles son los territorios reales, vividos, legales, posibles y pensados? ¿Cómo se construyen esos espacios soñados por la economía social y solidaria que nos permitirían llegar a un buen vivir? Estas preguntas son la base de este libro, cuyo objetivo es entender la relación existente entre la teoría y la práctica de la economía solidaria en Latinoamérica y Colombia. Nuestro análisis nos ha permitido comprender que el territorio es un espacio de poder y una construcción social donde se superponen distintas ideas e ideales que se encuentran en disputa. A partir de allí, hemos hecho un examen histórico y documental sobre la evolución de la teoría y su aplicación, el cual nos muestra que no se puede hablar de una sola forma de hacer o pensar que asegure las transformaciones necesarias para conseguir un buen vivir. Contrario a esto, lo que encontramos es la reafirmación de la heterogeneidad y la multiplicidad de condiciones que determinan las formas en que pueden construirse las diferentes ideas de territorio, calidad de vida, habitar o bien común. Este libro es la invitación a pensar estas diferencias y a construir a partir de ellas.
Sharing the Resource
Authors: De Lisle Harold F.
Published: March 2023

The competitive exclusion principle would seem to apply to six species of rattlesnakes in the genus Crotalus, all of which feed mostly on small mammals. In Joshua Tree National Park, California, however, six species occur in an area of just 400,000 ha. A pattern noted in ecology is that diversity at one level begets diversity at other levels. Almost 70 years of locality data combined with present field research was used as evidence for the hypothesis that these rattlesnake species mostly avoid competitive exclusion by microhabitat differences within the great diversity of ecological communities in the park. These long-term records might also indicate that the dynamics of the desert ecosystem could be changing, possibly the result of climate change and/or local urbanization.
Suburbanization of a Central Texas Herpetofauna
Authors: Gehlbach Frederick R.
Published: March 2023

Reptiles and amphibians were surveyed on the Balcones Escarpment in central Texas as the area was transformed into suburbia. Of four habitats, oak-juniper savanna was totally destroyed and a quarter of the adjacent oak-juniper woodland was eliminated, but two creeks and most deciduous riparian forest remained. Extirpation of 12 of 30 species (40%) included 55% of nine amphibian species, 50% of two turtles, 33% of six lizards, and 30% of 13 snakes. Herpetofaunal richness declined exponentially from 1965 to 1990 with increased house building, then stabilized through 2005 as building slowed and stopped. Species survival was related to use of cultural and remaining natural habitats, secretive behavior, and human interest.
Some Natural History Notes on the Brooding Behavior and Social System of Two Oklahoma Skinks, Plestiodon fasciatus and Plestiodon obtusirostris
Authors: Cavalieri Cybil N. , Fox Stanley F.
Published: March 2023

The purpose of this study was to quantify the social and reproductive behavior of Plestiodon fasciatus and P. obtusirostris. We conducted laboratory experiments with brooding behavior and field experiments to test for mate-guarding and territoriality. To determine the use of space by both species, we conducted a mark-recapture study. We constructed two permanent 1-ha trapping grids of can pitfall traps and cover-boards, with an inter-trap distance of 10 m. One was in a mixed woodland-grassland habitat and one in a grassland habitat. We manipulated the hydric environment to determine parental behavior of brooding female P. obtusirostris. We size-matched male P. fasciatus and P. obtusirostris for dyadic encounters with and without females and both on and off home ranges in order to determine social behavior. Change in hydric conditions did not induce female P. obtusirostris to move eggs to more suitable nest sites in our experiments. Plestiodon fasciatus exhibited behavior associated with mate-guarding. Plestiodon obtusirostris did not display behavior associated with territoriality, and our experiment examining mate-guarding calls for a more intensive study.
Improving the efficiency of electric transport systems using energy storage units
Authors:   Novosibirsk State Technical University, Russian Federation, Shtang Alexander A. , Biryukov Valeriy V. ,   Novosibirsk State Technical University, Russian Federation
Published: March 2023

The complex of issues related to the saving of electric energy in all elements of the technological chain of urban electric transport from the power source to the rolling stock is considered in the monograph. The monograph is intended for specialists in the field of electric transport and students majoring in power and electrical engineering as an additional source to form a holistic view of the state of affairs and prospects for the development of energy saving in vehicles with an electric drive.
Reliability analysis method of coupling optimal importance sampling density and multi-fidelity Kriging model
Authors: Xie Jiayu , Tian Zongrui , Zhi Pengpeng , Zhao Yadong
Published: March 2023

The commonly used reliability analysis approaches for Kriging-based
models are usually conducted based on high-fidelity Kriging models.
However, high-fidelity surrogate models are commonly costly.
Therefore, in order to balance the calculation expense and calculation
time of the surrogate model, this paper proposes a multi-fidelity Kriging
model reliability analysis approach with coupled optimal important
sampling density (OISD+MFK). First, the MEI learning function is
proposed considering the training sample distance, model computation
cost, expected improvement function, and model relevance. Second, a
dynamic stopping condition is proposed that takes into account the
failure probability estimation error. Finally, the optimal importance
sampling density is incorporated into the reliability analysis process,
which can effectively reduce failure probability estimation error. The
results of the study show that the approach proposed in this paper can
reduce the calculation cost while outputting relatively accurate failure
probability evaluation results.
Spanish-Portuguese Serial Fiction as a Politainment Tool: Representations of Politics on Iberian Television
Authors: Chicharro-Merayo Mar , Gil-Gascón Fátima , Baptista Carla
Published: March 2023

This article deals with recent Spanish and Portuguese political television series. Within this sub-genre, it is pertinent to consider the symbolic construction of politics, as well as the differences caused by each series’ geographical adscription. Six Spanish productions have been selected—Isabel (Isabella the Catholic), Carlos Rey Emperador (Charles the Emperor King), La Embajada (The Embassy), Crematorio (Crematorium), Vamos Juan/Venga Juan (Come on, Juan/Let’s go Juan), and El Partido (The Party)—along with three Portuguese productions—A Rainha e a Bastarda (The Queen and the Bastard), Teorias da Conspiração (Conspiracy Theories), and Os Boys (The Boys). The narrative of these audio-visual stories has been examined utilising qualitative content analysis, looking at the plotlines and characters involved. The type of characterisation of politics has been identified by means of the deconstruction of the main characters. The conclusion is that the evaluation is eminently negative, although differential frameworks are present, depending, in particular, on the fiction’s genre, either historical drama, drama-thriller, or comedy.
FUNCTIONALITY OF SPATIAL ANALYSIS IN THE ASSESSMENT OF THE IMPACT OF LAND COVER ON THE EROSION PROCESS PREDICTION
Authors:   Kazimierz Wielki University, Poland, Szatten D. , Herman O. ,   Kazimierz Wielki University, Poland, Tęgowska N. ,   Kazimierz Wielki University, Poland
Published: March 2023

Erosion is a process shaping the earth’s surface, responsible for supplying sediment to the fluvial system. Identification of areas vulnerable to erosion is a critical element of sediment management in the catchment, enabling the assessment of the degree of its degradation. The research was based on the use of spatial data, Digital Terrain Model (DTM), and Corine Land Cover (CLC) on the example of two sub-catchments located on the lower Brda River. The main aim of the research was to assess the impact of land cover on the spatial prediction of the erosion process at the catchment scale. The Maximum Entropy Method was used to determine the spatial probability distribution of environmental variables related to the erosion process. Results showed the greatest predictive power of relief-related environmental features, associated with specific types of land cover. Predictive models can be successfully used to predict areas potentially exposed to erosion
Fault Roughness at Seismogenic Depths and Links to Earthquake Behavior
Authors: Cochran Elizabeth S. , Page Morgan T. , van der Elst Nicholas J. , Ross Zachary E. , Trugman Daniel T.
Published: March 2023

Fault geometry affects the initiation, propagation, and cessation of earthquake rupture, as well as, potentially, the statistical behavior of earthquake sequences. We analyze 18,250 (−0.27 < M < 4.4) earthquakes of the 2016–2019 Cahuilla, California, swarm and, for the first time, use these high-resolution earthquake locations to map, in detail, the roughness across an active fault surface at depth. We find that the strike-slip fault is 50% rougher in the slip-perpendicular direction than parallel to slip. 3D mapping of fault roughness at seismogenic depths suggests that roughness varies by a factor of 8 for length scales of 1 km. We observe that the largest earthquake (M 4.4) occurred where there is significant fault complexity and the highest measured roughness. We also find that b-values are weakly positively correlated with fault roughness. Following the largest earthquake, we observe a distinct population of earthquakes with comparatively low b-values occurring in an area of high roughness within the rupture area of the M 4.4 earthquake. Finally, we measure roughness at multiple scales and find that the fault is self-affine with a Hurst exponent of 0.52, consistent with a Brownian surface.
Pengaruh Suhu dan Lama Penyimpanan Terhadap Karakteristik Fisikokimia, Organoleptik dan Mikrobiologis Jruek Drien (Durian Fermentasi Khas Aceh)
Authors: Murlida Eva , Wilfida Cut Wirna , Asmawati Asmawati
Published: March 2023

Durian is a horticultural product that is easily damaged so it needs to be processed into other products. One of them can be processed into jruek drien. Jruek drien is one of the efforts made to extend the shelf life by means of fermentation. The purpose of this study was to determine the effect of temperature and duration of storage time on the physicochemical, microbiological and organoleptic on jruek drien characteristic. This study used a factorial randomized block design with two factors, namely the storage temperature with two level (room temperature and refrigerator temperature) and storage time with three levels (3, 6, 9 days) with 3 replicatons. The average value of each parameter is pH 4,1, total acid 1,26%, total lactic acid bacteria 7,14 log CFU/g and organoleptic values of color, aroma, taste and texture are 3.24 (neutral), 2.71 (neutral), 2.63 (neutral), 3.08 (neutral) respectively. Temperature and storage time and their interaction greatly affect the pH and total acid in the juicer. Temperature significantly affected the total lactic acid bacteria and organolepti test of color and aroma. The best result in making  jruek drien is refrigerator temperature storage with six days of storage.
Láser de baja potencia como alternativa terapéutica al eritema multiforme idiopático. Informe de caso
Authors: Gamarra-Insfrán José Miguel , Ruiz Diaz-Barrios María Clara , Giménez-Leguizamón Micaela Belén , González Galván María del Carmen , Espínola Mirtha Daniela , Cantero-Viñarro María Fátima
Published: March 2023

El eritema multiforme es una enfermedad aguda de la piel y/o de las mucosas de naturaleza inmunológica, siendo está de etiología desconocida. Solo el 20% de los casos se dan en niños. El diagnóstico se basa en la historia clínica y el examen físico y el tratamiento no está sistematizado. La terapia con láser de baja potencia está siendo cada vez más utilizada en el campo estomatológico. El objetivo fue evidenciar los beneficios del láser de baja potencia como alternativa terapéutica. Este caso corresponde a un paciente de 10 años de edad, que acudió a la cátedra de Patología Bucal de la Facultad de Odontología de la Universidad Nacional de Asunción (UNA), derivado del Hospital General de Barrio Obrero con antecedentes de internación por presentar lesiones erosivas en labios, boca y máculas en toráx, abdomen, orejas y miembros. En el examen intraoral costras serohemáticas negruzcas en labios, lesiones ulceradas en lengua, piso de boca, paladar duro y mucosa yugal. Se procedió a hacer una lavado de la zona con agua oxigenada, en las áreas afectadas se colocó azul de metileno al 0,01% por 5 minutos, y para la aplicación de laserterapia se realizó una única sesión. El paciente mostró gran evolución a las 24 horas de la aplicación del tratamiento. A los 8 días estaba sin lesiones y asintomático. La fotobioestimulación a nivel celular que ofrece el láser de baja potencia es una herramienta verosímil que se suma a nuevas opciones terapéuticas.
Relação entre diferentes decisões financeiras no Brasil: Investimento, Financiamento e Payout
Authors: Da Costa Gomes Matheus , Eça João Paulo Augusto , Fernandes Marlos , Do Valle Mauricio Ribeiro
Published: March 2023

Este trabalho tem por objetivo analisar se as decisões de investimento e de financiamento são fatores relacionados às decisões de payout nas empresas brasileiras de capital aberto. Com base na Teoria da Política de Payout, analisou-se uma amostra composta por 307 companhias listadas na B3, no período entre 2010-2018, utilizando um modelo de regressão linear com dados em painel (com efeitos fixos da firma). Os resultados apontam que as decisões de investimento (Capex) afetam positivamente o payout, assim como as decisões de financiamento (alavancagem) também se mostraram positivamente relacionadas ao payout das empresas. Conclui-se que a política de payout deve ser posta em conjunto com as políticas de financiamento e de investimento, para uma melhor compreensão da primeira.
Incubadoras de negocios, desempeño y eficacia: una revisión sistemática
Authors: Flores-Bueno Daniel , Jerez Oscar
Published: March 2023

Desde su aparición en los años cincuenta, hasta su popularización a finales de los noventa, las incubadoras de negocios han promovido el emprendimiento y la innovación a nivel mundial. Este artículo propone una revisión sistemática de la literatura sobre la evaluación de su desempeño a nivel global. Se analizaron 75 artículos provenientes de Scopus y Web of Science desde 2015 hasta el 2021 y se identificaron siete tipos de evaluaciones: 1) gestión de procesos, 2) resultados finales 3) evaluación comparativa, 4) impacto de redes externas, 5) aprendizaje, 6) comportamiento del incubado y 7) evaluación de la literatura de incubación. Este estudio contribuye con la identificación de un cambio significativo en cuanto a la metodología con predominio de lo cuantitativo (44 apariciones) sobre lo cualitativo (11 apariciones) y lo mixto (12 apariciones). En cuanto a la teoría, se encontró una gran dispersión. Para terminar, se propone una agenda de investigación.
Evolución de la investigación científica sobre electronic word of mouth en la industria del turismo: un análisis bibliométrico
Authors: Osorio-Andrade Carlos Fernando , Arango Pastrana Carlos Alberto , Rodríguez Orejuela Augusto
Published: March 2023

The research status of electronic word of mouth in the tourism sector was evaluated and a research agenda was formulated. Through bibliometric analysis, 1017 scientific articles indexed in Scopus between 2008 and 2021 were reviewed. Descriptive indicators, qualitative analysis of texts, and maps of social networks allowed to summarize the literature. Six research streams were identified: automatic classification of texts, content generated by tourists, eWOM valence, decision making, impact of eWOM on performance, and impact on trust. For future research, it is suggested to include topics such as elements that favor eWOM, effects of business attributes on eWOM, factors driving the generation of eWOM, changes in eWOM behavior and online reviews, and business management.
El informe pericial probatorio de gradualidad de lesión psíquica o afectación psicológica en denuncias por violencia familiar en Lima, Perú
Authors: Arce Zavala Ruth Isabel , Moreno Galindo Eliseo , Rodríguez Ludeña Manuel Francisco
Published: March 2023

Frente a la alta incidencia que se viene presentado en los despachos de las fiscalías especializadas en violencia contra las mujeres y demás miembros del grupo familiar en el distrito fiscal de Lima (Perú), común denominador de muchas otras fiscalías, los operadores de justicia no han logrado integrarlas desde una adecuada gestión y aplicación de las mismas.La investigación tuvo como objetivo investigar la incidencia que tiene el informe pericial psicológico en la determinación del daño psíquico o afectación psicológica cognitiva o conductual en las denuncias por violencia familiar, frente al alto índice de violencia suscitado en agravio de las mujeres.La metodología utilizada es de enfoque cualitativo, con un nivel de investigación de análisis temático descriptivo y revisión estructurada.La conclusión precisa que los informes psicológicos emitidos por el Centro Emergencia Mujer (CEM), en el distrito fiscal de Lima, no han cumplido con los parámetros establecidos en la Guía de Evaluación Psicológica Forense, lo que conlleva a una ineficaz determinación del daño psíquico o afectación psicológico, cognitivo y conductual en las víctimas de violencia familiar.
Literate Change Agents Working in Oral Communities
Authors: Manley Regina Marie
Published: March 2023

This research documents the experience of 12 local leaders implementing an oral curriculum over 13 months in
Karnataka, India. These leaders were Change Agents interested in influencing a community with new information.
They created audio materials referred to as “content” in their group’s mother tongue: In a Kannada-Telegu mix for
the Madiga group (a Scheduled Caste); in Vaagri Booli for the Hakkipikki group (a Scheduled Tribe); and in Kannada
for the Kannadiga group. The first two languages are unwritten. The Kannada language is the official language of
Karnataka state. The oral curriculum followed the Spoken Worldwide® model. Each team of local leaders designed their
content by combining a topic, a local proverb, and an informative resource in story form. Next, the individual leaders
facilitated discussion groups in their community centered on the content. Eighteen men were interviewed; this included
six community discussion group members.

The Connected Learning Framework was the conceptual lens for this research. It consists of four constructs—relationship,
relevance, oral modes of communication, and mutual respect. Relationships played a primary role because the learners preferred
to work with individuals they knew, or with individuals who were approved by the community’s leaders. Content that centered on
what was relevant to community members was well-received by the listeners. The leaders used modes of communication that were
familiar to community members by presenting content in the mother tongue and including local proverbs. By facilitating discussion
after presenting the content, the leaders demonstrated mutual respect ensuring a multidirectional flow of information. This informed
how the leaders created subsequent content.

This research found that introducing new ideas, specifically Christian Scripture as a source of wisdom, was received positively
by almost all audiences. In addition, the Team Leaders who had more experience using oral modes of communication, specifically
telling Bible stories, and facilitating discussion were more consistent in implementing the Spoken process and principles and
modeled the process during the content creation sessions with their Local Leaders or in presenting the content in their Leader’s
gatherings. These leaders who had more experience with Connect Learning strategies were able to navigate further in the oral learning paradigm.
Understanding Students' Experience with 1:1 Computer-Supported Collaborative Learning in a Mathematics Classroom
Authors: Perales Aguilera Oscar Antonio
Published: March 2023

There has been a move towards integrating educational technology into K-12 mathematics classrooms. This emphasis has been partly driven by
policy, increases in technology resources available, and a need to engage students in their mathematical learning. Most studies on technology
integration in mathematics education are focused on teachers’ perceptions or students’ academic achievement. However, we need to learn how
students perceive their learning in this type of environment. This dissertation is a basic qualitative study aimed at understanding the
experiences of students with 1:1 computer-supported collaborative learning (CSCL) in an Algebraic Reasoning classroom. The study used the
mathematical software, Desmos, as its CSCL system. The school in which this research took place fully implemented a 1:1 student-to-Chromebook
program since 2016, and the participants of this study were students in a 1:1 Algebraic Reasoning classroom. The data used in this study were
taken from participants’ responses to individual semi-structured interviews about their learning experiences with Desmos. Data was analyzed
using Kumar et al.’s (2010) framework for effective CSCL systems which encompasses five criterions: (1) Open-ended and guided interactions,
(2) interactions that can be stored centrally for meaningful interpretation, (3) predefined collaboration strategies, (4) underlying theories
of collaboration represented in the software, and (5) providing active and passive feedback. Results suggest that students' experiences with
1:1 CSCL in Algebraic Reasoning captured all but one them. These elements can inform educational stakeholders as to how to implement an
engaging, innovative, and student-centered 1:1 CSCL mathematics environment.
Using Food-Industry Byproduct to Treat Expansive Clay
Authors: Shaw Nicole L.
Published: March 2023

Lime stabilization has proven to be a valuable method in improving the properties of expansive clays under light structures such as those
in transportation projects where ground improvement methods are often necessary over a large area. Hydrous and quick lime products are
also utilized in various types of food processing operations to remove impurities from agricultural products. During this purification,
waste is produced consisting of precipitated calcium carbonate, organic debris, and trace amounts of soil and agricultural contaminants.
This food-processing waste typically contains commercially available unspent lime products, which are still viable for construction
applications. Hence, this type of waste could be viewed as a byproduct to be reused or recycled.

The waste is generated in excess of 100,000 tons per year per site when produced in large-scale operations. The volume produced is too
large to be sent to landfills and is not compostable due to its chemical composition. Therefore, the waste is typically stockpiled on land
adjacent to food processing facilities. There is potential to save capital on construction projects as well as significantly save in land
investment by food processing facilities if a more environmentally and economically sustainable solution is found to utilize, reuse, or
recycle this material. This paper studies the potential to use agricultural and food industry waste in construction applications where
the organic content by weight is consistently measured at lower than 5%. Using a series of geotechnical and environmental laboratory testing
procedures, several engineering properties (e.g., swell potential, permeability, and strength properties) of various blends of this waste and
expansive clay are measured to find the right series of tests to evaluate this potential. Preliminary testing on a series of blends with an
expansive clay suggests decreased swelling potential, increased density, and potential leachate immobilization. Once more blends have been
studied and procedures have been standardized, these materials may also produce a secondary revenue stream for certain food processing
facilities when utilized in construction applications.
Game-Based Learning
Authors: Ward Sean
Published: March 2023

Video games have become a popular and accepted part of digital culture and are becoming more accepted as an engaging
instructional tool in schools. Integration of games can help develop students’ intrinsic motivation for learning and are
a great way for teachers to incorporate student interests and make connections to the curriculum. Classroom usage of digital
games is becoming more widespread, but prior research suggests that game-based learning is underutilized as a tool in the teacher
toolbox. This study seeks to understand the factors that influence teachers’ decisions to use or not use digital games in their classroom
and make suggestions for convincing reluctant teachers to increase usage of game-based learning in the future.

This study uses a survey-based concurrent embedded research design. Participants in the study were 133 current K-12 educators in
the United States. Quantitative data was analyzed using SPSS software and path analysis was used to determine the factors that
influence a teacher’s intention to use digital games and actual reported usage of digital games in the classroom. Open-ended
responses were analyzed using a word frequency and theme-based approach.

Overall, the data shows that teachers are integrating digital games into their instruction, with 86% of teachers reporting usage
of digital games at least once per week. Teacher perceptions, knowledge of games and teaching with games, and experiences with games
were identified as factors influencing digital game usage in the classroom. Findings suggest that ongoing professional development
opportunities for teachers can positively affect teacher perceptions and help resistant teachers overcome perceived barriers and increase
classroom usage of GBL.
Automatic Generation of Ontologies Based on Articles Written in Ukrainian Language
Authors: Zhezherun Oleksandr , Ryepkin Maksym
Published: March 2023

The article presents a system capable of generating new ontologies or supplementing existing ones based on articles in Ukrainian. Ontologies are described and an algorithm suitable for automated concept extraction from natural language texts is presented.Ontology as a technology has become an increasingly important topic in contemporary research. Since the creation of the Semantic Web, ontology has become a solution to many problems of understanding natural language by computers. If an ontology existed and was used to analyze documents, then we would have systems that could answer very complex queries in natural language. Google’s success showed that loading HTML pages is much easier than marking everything with semantic markup, wasting human intellectual resources. To find a solution to this problem, a new direction in the ontological field, called ontological engineering, has appeared. This direction began to study ways of automating the generation of knowledge, which would be consolidated by an ontology from the text.Humanity generates more data every day than yesterday. One of the main levers today in the choice of technologies for the implementation of new projects is whether it can cope with this flow of data, which will increase every day. Because of this, some technologies come to the fore, such as machine learning, while others recede to the periphery, due to the impossibility or lack of time to adapt to modern needs, as happened with ontologies. The main reason for the decrease in the popularity of ontologies was the need to hire experts for its construction and the lack of methods for automated construction of ontologies.This article considers the problem of automated ontology generation using articles from the Ukrainian Wikipedia, and geometry was taken as an example of the subject area. A system was built that collects data, analyzes it, and forms an ontology from it.
Software System of Checking for Plagiarism of Ukrainian Texts
Authors: Hlybovets Andrii , Bikchentaev Mykola
Published: March 2023

The purpose of this work is to describe the methodology of building a software system (application) for plagiarism checking of scientific publications in the Ukrainian language using two machine learning models, Word2Vec and BERT. We consider the detection of external plagiarism in Ukrainian texts.Plagiarism is usually defined as the passing off someone else’s ideas as your own. As the Internet becomes more and more accessible every day, a huge amount of data becomes available to people. Nowadays, it is quite easy to find a suitable study and plagiarize it instead of developing one’s own from scratch.Plagiarism undermines the efforts of the researcher whose work has been plagiarized and gives the plagiarist the opportunity to over-praise himself; such a person can be detrimental when appointed to an important position.Many fields of life are susceptible to plagiarism, including research and education. Plagiarism can also take many forms: from straight up copy-paste to paraphrasing and sentence restructuring. This makes plagiarism a rather complex problem, where methods, such as longest common subsequence or n-grams, based on finding shared words between documents, might not work. Therefore, we might consider applying deep learning to the problem of plagiarism detection.In this article we discussed the concept of plagiarism and listed its types. Two machine learning models have been proposed for plagiarism detection: Word2Vec and BERT. We also provided an overview of both models and described how they could be used in the problem of plagiarism detection.A web application for plagiarism detection in the Ukrainian language has been developed. This application features React, a JavaScript framework, on the frontend and Python on the backend. To store application data, MongoDB is used.This application allows a user to input a text that will be compared with the texts from the application database using cosine similarity or Euclidean distance as metrics. Comparison is performed using word embeddings, calculated by pre-trained BERT or Word2Vec model. A user can choose the model and similarity metrics using the application’s UI.The application can be further improved to not only output similarity metric but also highlight the similar sentences in the texts.
Bicycle Protection System Using GPS/GSM Modules аnd Radio Protocol
Authors: Gorokhovskyi Semen , Аlieksieiev Аnton
Published: March 2023

Bicycle security systems have not developed as much as home security, and it is difficult to find competitive examples when researching the market. Many security systems on the market have weaknesses that can be bypassed or are not convenient to use. The technologies used to protect bicycles are rather uniform, predictable and not reliable. Most of such systems do not have convenient means of monitoring, such as, for example, a mobile application. Improvement of these systems, introduction of new technologies is very relevant in the field of bicycle protection. This is due to the unpopularity of these systems, their unreliability and lack of control over the phone. The majority of bicycle users are inclined to use proven methods – bicycle locks. But this decision is wrong.The system with GPS is so easy not to be deceived – it has more than one level of protection, and quickly warns the user about a threat. It has deterrents and means of attracting the attention of others.In addition, the use of GSM technology facilitates the possibility of control through a mobile application, which simplifies work with the system.Using GPS is the best way to monitor the position of the bicycle in space, and to track movement in unpredictable circumstances. GPS opens a number of possibilities and increases the functionality of the system. From monitoring the situation of the protection object to collecting statistics].The GSM module is almost never used in bicycle security systems. This is due to the concept of bike guarding, which says why use the ability to transmit data to any corner of the world if the user does not move more than 100 meters from the guarded object. But this concept is wrong. GSM is one of the fastest solutions among analogs. But transmission speed is not the only criterion for information transmission in wireless systems.Since the bicycle is a moving object, and the security system must be wireless, an important criterion for the functioning of such a system is the operating time.This article deals with the problem of protecting a moving object, using GSM and GPS modules. The main features of existing systems in this area, their advantages and disadvantages are shown. The advantages of using a radio protocol for bicycle protection are given. A model of the system that meets the needs of the user has been developed.
Two-Stage Transportation Problem with Unknown Consumer Demands
Authors: Stetsyuk Petro , Khomiak Olga , Lіashko Volodymyr
Published: March 2023

The work investigates a mathematical model of a two-stage transportation problem for finding the most economical plan for the transportation of homogeneous products from suppliers to consumers, where the demands of consumers are unknown, taking into account constraints on their lower and upper bounds. It is an extension of the classic two-stage transportation problem, where products are transported from suppliers to consumers only through intermediate points. Intermediary firms and various storage facilities (warehouses) can be such intermediate points.The relationship of the developed mathematical model with the two-stage continuous-discrete problem of optimal partitioning-distribution, which is characterized by the presence of two stages, is investigated. The problem consists in determining the areas of collection of the continuously distributed resource (raw material) by enterprises of the first stage and the volumes of transportation of the processed product from the enterprises of the first stage to consumers (points of the second stage), in order to minimize the total costs of transportation of the resource from suppliers to consumers through processing points (collection points, storage points).The material of the article is presented in two sections. Section 1 describes the mathematical model of the two-stage transportation problem with unknown consumer demands and provides the necessary and sufficient conditions for the compatibility of the system of linear constraints. It is shown that its special case coincides with the classic two-stage transportation problem.Section 2 provides a description of the model problem of optimal partitioning-distribution for the continuous area Ω and the discrete analog of the model problem. The results of computational experiments for a rectangular area Ω = {x = (x(1), x(2)) : 0 ≤ x(1) ≤ 1, 0 ≤ x(2) ≤ 1} with discretizations by grids 31 × 31 and 500 × 500 are presented. Optimal plans for transportation of processed product from points of the first stage to points of the second stage for both grids were found. The average time spent by the Gurobi solver to solve problems for the second grid, where the number of variables equals 250018 and the number of constraints equals 250009, is a few seconds on modern PCs.
EXPERIMENTAL ECONOMY AND SOCIAL ENGINEERING: COMMON AND DIFFERENT
Authors: Kudinova A. V. , Kyrianova O. V. , Dvornyk I. V.
Published: March 2023

The last 30-50 years of the development of economic science were marked by the rapid development of new directions of research, and interdisciplinary, which today is increasingly entering the social sciences, only strengthened this trend. Behavioral economics, global political economy, experimental economics, social engineering, information economics, post-industrial economics, etc. In particular, global institutional changes, the Covid-19 pandemic and the war with Russia led to the actualization of the concept of "social engineering" in the domestic socio-economic and political space, and the results of experimental economics research are actively used not only in fundamental and theoretical research, but also in real economic practice. which unfolds the status of economic science in a completely different way - economics becomes a truly empirical science. The article examines theoretical and methodological aspects of experimental economics and social engineering. The content of the "social engineering" category was clarified, a comparative analysis of approaches was carried out, and the methodological principles of theimplementation of social engineering were determined. Thus, it was found that the vast majority of domestic scientists consider social engineering from the standpoint of a system of constructing a new social reality, a specific social practice of managing industrial objects, and an experimental technology for changing social life. Experimental economics, as one of the newest directions of economic science, is analyzed in the context of key studies of Nobel laureates, representatives of experimental economics. Despite certain similarities between social engineering and experimental economics, the authors conducted a critical analysis of these two directions, identified fundamental differences in approaches, limits, and opportunities of each.
INFLUENCE OF SYSTEMATIC STRATEGIC PLANNING AND STRATEGIC BUSINESS INNOVATIONS ON THE FOREIGN ECONOMIC ACTIVITY OF ENTERPRISES
Authors: Kulish D. V. , Holoborodko H. Y.
Published: March 2023

The article examines the theoretical and methodological aspects of the influence of systematic strategic planning and strategic business innovations on the foreign economic activity of enterprises. It was found that in a dynamic business environment, the ability of enterprises to quickly and effectively adapt is a critical success factor that requires a clear strategy. Thus, systematic strategic planning has grown to the point where its main value lies in helping businesses operate successfully in a dynamic and complex environment and navigate an increasingly unpredictable environment. It is justified that social, environmental and economic indicators are considered simultaneously as a whole, and not independently, as a means of conducting business through obtaining profit, promoting the efficiency of the enterprise, involvement in social harmony and environmental protection, which can help to find practical recommendations and theoretical foundations, that will help businesses grow, thrive and stay in business.
It is substantiated that the top management of manufacturing small and medium-sized enterprises should realise the need for systematic strategic planning of foreign economic activity, which can lead to an improvement in sustainable productivity. In addition, since strategic business innovation is crucial for the sustainability of manufacturing enterprises and is a significant source of competitive advantage, additional attention should be paid to the development of an innovative culture within the enterprise. This indicates that these practices must exist for this culture to emerge. Thus, decision-makers must realise the added value potential of strategic business innovations and systematic practices of strategic planning of foreign economic activities of enterprises.
PROBLEMS AND PERSPECTIVES OF THE FUNCTIONING OF NATIONAL LOGISTICS SYSTEMS ON AGRICULTURAL PRODUCT MARKETS
Authors: Radchenko O. P.
Published: March 2023

This article examines the main trends in the creation and development of the logistics concept in normal conditions and in the conditions of military operations on the territory of Ukraine, where, in particular, an analysis was carried out and, based on its results, the main elements of the functioning of logistics systems to ensure the competitive advantages of agricultural entities in the food market were identified. The leading role of the supply chain of agricultural products in logistics is emphasized and the scenarios of its development under the influence of external factors are considered. At the same time, the main aspects of the restoration of supply chains, taking into account large-scale military operations on the territory of Ukraine, are highlighted in such areas as transparency in the supply chain, availability of stocks, realistic demand of the end consumer, etc. In addition, it has been proven that logistics is one of the key elements of the development of the state'seconomy in general and the agricultural industry in particular. It has been determined and proven that the prospects for the development of the logistics services market in Ukraine directly depend on the state of the country's economy as a whole. In the process of writing the article, one's own vision of the functioning and peculiarities of logistics chain management in conditions of uncertainty and the influence of negative trends was proposed. These trends include: a decrease in export and import volumes due to the blockade of ports; changing the structure of logistics flow directions; a significant increase in risks and unforeseen threats to the supply of goods. The proper definition and conditions of functioning of logistics chains of agrarian enterprises in conditions of full-scale war are given.