bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic factors and the role of adjuvant radiation therapy in Non-melanoma skin cancer: Retrospective, A single-center experience
Authors: lmaz Emine
Published: April 2023

Objective: Non-melanoma skin cancer (NMSC) is the most prevalent malignancy worldwide, with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) representing the most common types of NMSC. In this retrospective analysis, patients with NMSC who had adjuvant radiotherapy (RT) had their treatment results and prognostic variables evaluated.

Material and Methods: A total of 115 patients with NMSC who had adjuvant RT in our clinic during January 2006 and September 2021 were assessed. The average age was 74 years, and the male to female ratio was 1.95:1. (range: 25–95). The most often diagnosed kind of NMSC was SCC (93%, n=107), preceded by BCC (7%, n=8). The extremities (17.4%, n=20), the trunk (1.7%, n=2), and the head and neck area (80.9%, n=93) were where the bulk of NMSC lesions were discovered.

Results: The mean follow-up period was 60.7 months (the range was 4.2–194.7); metastases were found in six patients (5.2%), and locoregional recurrence was identified in 24 patients (20.8%). The 3- and 5-year total survival percentages were 71.2% and 59.3%, respectively, and the median overall survival (OS) time was 87.1 months. Tumor size and surgical margin status were linked to a worse OS in multivariate analysis of prognostic variables (hazard rate [HR]=3.0, 95% confidence interval [CI]: 1.8-5.2; p=0,001 and HR=2.4, 95% CI: 1.4-4.1; P=0,002, respectively).

Conclusion: Postoperative RT is an efficient, acceptable therapeutic option for NMSC in high-risk individuals. Our results suggest that surgical margin and tumor size were independent predictors of OS in NMSC patients; nevertheless, future studies including more patients are required to corroborate these results.
Association of Liver and Renal Function Impairment with Major Cardiac Events in Heart Failure Patients
Authors: Akkaya Fatih , Kaya Ahmet , Kaya Yasemin , Dereli Se , Filiz Mehmet
Published: April 2023

Aim: We aimed to show whether liver and renal function tests impairment have an effect on cardiovascular major adverse events (MACE) in patients with chronic heart failure (CHF).
MateriaL and Method: 514 Patients with Ejection Fraction (EF) 40% were screened retrospectively. Biochemical and hemogram parameters of the patients at the first admission were recorded. GFRs were calculated with the MDRD formula. Patients were classified into four groups based on whether they had just a kidney injury, only a liver damage, both a kidney and liver injury, or neither a kidney and liver injury. Exitus, stroke, and hospitalization were taken as major cardiovascular adverse events, and whether they had a major cardiovascular adverse event within one year was recorded.
Results: There was no difference between the groups in terms of exitus. When the groups were compared, a difference was found between the groups in terms of stroke, hospitalization, and MACE rates (p=0.001; p= 0.017; p=0.004, respectively). Stroke rate (13.8%) in the only kidney injury group; hospitalization (24%) and MACE (38%) in the liver + kidney injury group were found. As a result of binary logistic regression analysis, it was found that creatinine and EF predicted hospitalization for CHF, stroke, and MACE.
Conclusion: In heart failure patients, the rate of stroke was higher in the group with only kidney injury, and the rates of hospitalization and MACE were higher in the group with both liver and kidney injury. It was found that creatinine and EF predicted hospitalization, stroke, and MACE from CHF.
A ÉTICA NO PROCESSO DE FORMAÇÃO E ATUAÇÃO DO DOCENTE
Authors: Meninea Antonio Danilo Bentes , Maia Patrícia Ribeiro , Nunes Emília do Socorro Conceição de Lima , Gomes Suzana Mourão , De Bastos Luana Brito Bluhm , Dos Santos Caila Rogéria Prazeres
Published: April 2023

Os professores são o alicerce de qualquer sistema educacional. Eles estão na conexão da transmissão de conhecimento, habilidades e valores. A postura ética do professor irá governar como ele instrui e avalia os alunos. A ética também desempenhará um papel importante na forma como um professor interage com estudantes, colegas, administradores e com a comunidade em geral. Portanto, o papel do professor na formação de valores morais nos alunos vai crescendo, na medida em que sua formação vai sendo eficientemente direcionada para tais valores morais, despertando reflexões éticas. A ética é o espelho que reflete os valores, os princípios, as normas, as regras de comportamento do homem. Os professores devem manter um comportamento ético na prática profissional. No presente artigo analisamos aspectos considerados relevantes no que diz respeito às definições e a relação da ética na formação dos professores; este estudo foi dividido nas seguintes partes: a primeira consiste em uma análise sobre a ética e moral na educação; na segunda destacamos o papel da ética na formação dos professores e por fim, na terceira observamos o professor e a ética profissional.
Adjuvant therapy for renal cell carcinoma
Authors: Lalani Aly-Khan A. , Kapoor Anil , Basappa Naveen S. , Bhindi Bimal , Bjarnason Georg A. , Bosse Dominick , Breau Rodney H. , Canil Christina M. , Cardenas Luisa M. , Castonguay Vincent , Chavez-Munoz Claudia , Chu William , Dudani Shaan , Graham Jeffrey , Heng Daniel Y.C. , Kollmannsberger Christian , Lattouf Jean-Baptiste , Morgan Scott , Reaume M. Neil , Richard Patrick O. , Swaminath Anand , Tanguay Simon , Wood Lori A. , Lavallée Luke T.
Published: April 2023

INTRODUCTION: Several recent randomized trials evaluated the impact of adjuvant immune checkpoint inhibitor (ICI)-based therapy on post-surgical outcomes in renal cell carcinoma (RCC), with disparate results. The objective of this consensus statement is to provide data-driven guidance regarding the use of ICIs after complete resection of clear-cell RCC in a Canadian context.
METHODS: An expert panel of genitourinary medical oncologists, urologic oncologists, and radiation oncologists with expertise in RCC management was convened in a dedicated session during the 2022 Canadian Kidney Cancer Forum in Toronto, Canada. Topic statements on the management of patients after surgery for RCC, including counselling, risk stratification, indications for medical oncology referral, appropriate followup, eligibility and management for adjuvant ICIs, as well as treatment options for patients with recurrence who receive dadjuvant immunotherapy, were discussed. Participants were asked to vote if they agreed or disagreed with each statement. Consensus was achieved if greater than 75% of participants agreed with the topic statement.
RESULTS: A total of 22 RCC experts voted on 14 statements. Consensus was achieved on all topic statements. The panel felt patients with clear-cell RCC at increased risk of recurrence after surgery, as per the Keynote-564 group definitions, should be counselled about recurrence risk by a urologist, should be informed about the potential role of adjuvant ICI systemic therapy, and be offered referral to discuss risks and benefits with a medical oncologist. The panel felt that one year of pembrolizumab is currently the only regimen that should be considered if adjuvant therapy is selected. Panelists emphasized current opinions are based on disease-free survival given the available results. Significant uncertainty regarding the benefit and harms of adjuvant therapy remains, primarily due to a lack of consistent benefit observed across similar trials of adjuvant ICI-based therapies and immature overall survival (OS) data.
CONCLUSIONS: This consensus document provides guidance from Canadian RCC experts regarding the potential role of ICI-based adjuvant systemic therapy after surgery. This rapidly evolving field requires frequent evidence-based re-evaluation.
ҲОЗИРГИ ЗАМОН ХАЛҚАРО МУНОСАБАТЛАРИДА ИСЛОМ ХАЛҚАРО ТАШКИЛОТЛАРИНИНГ РОЛИ
Authors: Ҳайдарали Ю.
Published: April 2023

Ушбу мақолада ҳозирги замон халқаро муносабатларида ислом халқаро таш-килотларининг роли таҳлил қилинган. Муаллиф ислом халқаро ташкилотлари оиласига ки-рувчи халқаро ҳукуматлараро ташкилотлар ва ноҳукумат уюшмаларга умумий тавсиф берган ҳамда уларнинг мақсад ва вазифаларига тўхталиб ўтган. Шунингдек, мақолада Ўзбекистон Республикасининг ислом халқаро ташкилотлари доирасидаги халқаро ҳамкорлик масалалари ҳам ёритиб берилган.

This article analyzes the role of Islamic international organizations in contemporary international relations. The author gives a general description of international intergovernmental organizations and non-governmental associations belonging to the family of Islamic international organizations and focuses on their goals and objectives. The article also covers issues of international cooperation of the Republic of Uzbekistan within the Islamic international organizations.

В статье анализируется роль исламских международных организаций в современных международных отношениях. Автор дает общую характеристику международных межправительственных и неправительственных организаций, принадлежащих к семейству исламских международных организаций, и акцентирует внимание на их целях и задачах. В статье также освещаются вопросы международного сотрудничества Республики Узбекистан в рамках исламских международных организаций.
ЖАМОАТ ХАВФСИЗЛИГИНИ ТАЪМИНЛАШДА ФУҚАРОЛИК ЖАМИЯТИ ИНСТИТУТЛАРИНИНГ ЎРНИ
Authors: Шухрат А.
Published: April 2023

Мақолада жиноятчиликнинг олдини олиш ва унга қарши курашишда ваколатли давлат идоралари фуқаролик жамияти институтлари ва фуқароларнинг фаол ижтимоий ҳамкорлигига таяниши ёритилган. Ушбу ҳамкорликнинг ҳуқуқий асослари ва муҳим йўналишлари илғор хорижий тажрибалар асосида атрофлича таҳлил қилиниб, уни ташкил этишнинг ижтимоий зарурати асослаб берилган.

The article highlights the fact that the competent government agencies in the prevention and fight against crime rely on the active social cooperation of civil society institutions and citizens. The legal basis and important directions of this cooperation have been thoroughly analyzed on the basis of advanced foreign experience, and the social necessity of its organization has been substantiated.

В статье подчеркивается тот факт, что компетентные государственные органы в области предупреждения преступности и борьбы с ней полагаются на активное социальное сотрудничество институтов гражданского общества и граждан. На основе передового зарубежного опыта тщательно проанализированы правовая основа и важные направления этого сотрудничества.
СУВ ВА СУВДАН ФОЙДАЛАНИШ СОҲАСИДА ПРОКУРАТУРА ФАОЛИЯТИНИ ТАКОМИЛЛАШТИРИШ МАСАЛАЛАРИ
Authors: Шавкатжон Р.
Published: April 2023

Мақолада сув ва сувдан фойдаланиш соҳасида прокуратура фаолиятини такомиллаштириш масалалари таҳлил қилинган. Бу борада ҳуқуқий адабиётларда илгари сурилган фикр-мулоҳазалар, миллий ва хорижий давлатлар қонунчилиги ўрганилган. Шу асосида илмий-назарий хулосалар ва таклифлар билдирилган.

The article analyzes the issues of improving the work of the prosecutor’s office in the field of water and water use. In this regard, the views expressed in the legal literature, the legislation of national and foreign countries are studied. On this basis, scientific and theoretical conclusions and recommendations are made.

В статье анализируются вопросы совершенствования деятельности прокуратуры в сфере водоснабжения и водопользования. На основания юридической литературы и законодательства Узбекстана и зарубежных стран формулируются научно обоснованные выводы и рекомендации
HUMAN RIGHTS AND THE RULE OF LAW AS THE CORNERSTONE OF EFFECTIVE COUNTER-TERRORISM EFFORTS
Authors: Dilnoza M.
Published: April 2023

In this article, the importance of human rights and rule of law in countering terrorism was analyzed.

Мазкур мақолада терроризмга қарши курашишда инсон ҳуқуқлари ва қонун устуворлигининг аҳамияти таҳлил қилинган.

В статье анализируются вопросы обеспечения законности и соблюдения прав человека в борьбе с терроризмом и экстремизмом.
SOME ASPECTS OF CHILDREN’S RIGHTS PROTECTION
Authors: Begzod U.
Published: April 2023

The article analyzes international and national regulations on the protection of the rights and freedoms of children, the measures taken in our country to ensure the rights of the child. Opinions were expressed on the responsibilities and obligations of the state, as well as parents or guardians in the development of a harmoniously developed generation.

Мақолада болаларнинг ҳуқуқ ва эркинликларини ҳимоя қилишга оид халқаро ва миллий норматив-ҳуқуқий ҳужжатлар, мамлакатимизда бола ҳуқуқларини таъминлаш бўйича амалга оширилаётган чора-тадбирлар таҳлил қилинган. Баркамол авлодни камол топтиришда давлат, шунингдек ота-оналар ёки уларнинг ўрнини босувчи шахслар зиммасидаги масъулият ва мажбурият тўғрисида фикр-мулоҳазалар билдирилган.

В статье анализируются международные и национальные нормативные акты по защите прав и свобод детей, меры, принимаемые в нашей стране для обеспечения прав ребенка.
ВАЖНЕЙШИЙ РЕСУРС ДЛЯ ЭКОНОМИЧЕСКОГО РОСТА И РАЗВИТИЯ
Authors: Гулнора А.
Published: April 2023

В статье проанализированы вопросы гендерного равенства, роли женщин в раз-витии национальных экономик, проблемы женского предпринимательства, особенности Стратегии достижения гендерного равенства в Республике Узбекистан до 2030 г., направленной на расширение прав и возможностей женщин, поощрение женского предпринимательства, повышение роли женщин во всех процессах государственного управления и общественной жизни.

Мақолада гендер тенглик масалалари, миллий иқтисодиёт ривожида аёлларнинг роли, тадбиркорлик фаолияти билан шуғулланувчи хотин-қизларнинг муаммолари, аёлларнинг ҳуқуқ ва имкониятларини кенгайтириш, уларнинг тадбиркорлик фаолиятини қўллаб-қувватлаш, давлат бошқаруви ва жамият ҳаётидаги барча жараёнларда хотин-қизлар ролини оширишга қаратилган 2030 йилга қадар Ўзбекистон Республикасида гендер тенгликка эришиш стратегиясининг ўзига хос хусусиятлари таҳлил қилинган.

The article analyzes the issues of gender equality, the role of women in the development of national economies, the problems of women's entrepreneurship, the features of the Strategy for achieving gender equality in the Republic of Uzbekistan until 2030, aimed at empowering women, encouraging women’s entrepreneurship, increasing the role of women in all processes of public management and public life.
ОБЕСПЕЧЕНИЕ ДОСТУПА К ПРАВОСУДИЮ ДЛЯ ЖЕНЩИН В УСЛОВИЯХ ПАНДЕМИИ И ЦИФРОВОЙ ТРАНСФОРМАЦИИ
Authors: Фируза Х.
Published: April 2023

Статья посвящена вопросам судебной защиты женщин в условиях пандемии и цифровой трансформации. В период пандемии COVID-19 наблюдался рост насилия в отношении женщин, однако карантинные ограничения стали препятствием для доступа к правосудию. Отмечается, что одним из частых нарушений в отношении женщин становится кибернасилие. По итогам исследования автор формулирует конкретные предложения, направленные на обеспечение судебной защиты женщин в условиях пандемии и цифровизации.

Мақола пандемия ва рақамли трансформация шароитида аёлларнинг суд ҳимоя си масалаларига бағишланган. Мақолада таъкидланишича, пандемия пайтида аёлларга нисбатан зўравонлик кўпайган, аммо карантин чекловлари адолатни тиклаш учун тўсиқ бўлиб келган. Бундан ташқари, муаллифнинг таъкидлашича, аёлларга нисбатан тез-тез учрайдиган қоидабузарликлардан бири киберҳужумдир. Таҳлиллар асосида муаллиф пандемия ва рақамлаштириш шароитида аёлларнинг суд ҳимоясини таъминлаш бўйича таклифларни илгари суради.

The article is devoted to the issues of judicial protection of women in the context of a pandemic and digital transformation. The article notes that during the pandemic, there was an increase in violence against women, but quarantine restrictions became an obstacle to access to justice. In addition, the author notes that one of the frequent violations against women is cyber violence. In conclusion, the author puts forward proposals for ensuring the judicial protection of women in the context of a pandemic and digitalization.
ВЛИЯНИЕ «ЦИФРОВОГО РАЗРЫВА» НА ПРАВА ЧЕЛОВЕКА
Authors: Шахсанем С.
Published: April 2023

Статья посвящена раскрытию понятия «цифровой разрыв» и оценке влияния этого явления на обеспечение прав человека в стране, а также анализу современных тенденций и статистики «цифрового разрыва». Автором сформулированы предложения по совершенствованию Конституции Республики Узбекистан путем закрепления нормы о гарантиях доступа к информации, а также внесены рекомендации по преодолению «цифрового разрыва».

Ушбу мақолада “рақамли тафовут” тушунчаси тавсифланган. Ушбу ҳодиса давлатда инсон ҳуқуқларини таъминлашга қандай таъсир қилиши, “рақамли тафовут”нинг замонавий тенденциялари ва статистикаси таҳлил қилинган. Муаллиф “рақамли тафовут” тушунчаси билан ўзаро алоқада ахборот олиш кафолати нормасини белгилаш орқали Ўзбекистон Рес публикаси Конституциясини такомиллаштириш бўйича таклифлар киритган, шунингдек, "рақамли бўлиниш"ни бартараф этиш бўйича хулоса ва тавсиялар берилган.

This article is devoted to explaining the concept of “digital divide” and how this phenomenon affects the provision of human rights in the country, analyzing current trends and statistics of the “digital divide”. The author makes proposals to improve the Constitution of the Republic of Uzbekistan, by enshrining the norm of guaranteeing access to information in interaction with the concept of “digital divide”, and also draws conclusions and recommendations for overcoming the “digital divide”.
КУЛЬТУРНАЯ ГОСУДАРСТВЕННОСТЬ КАК ОСНОВА ОБЕСПЕЧЕНИЯ ПУБЛИЧНОГО УПРАВЛЕНИЯ В НОВОМ УЗБЕКИСТАНЕ
Authors: Азамат Э.
Published: April 2023

В статье рассматриваются отдельные вопросы понимания в Узбекис тане гражданского общества, правового государства и правовой государственности, их соотношения с друг другом в контексте обозначенных подсистем социальной сферы государства. Анализируется основное содержание недостаточно изученных в национальной науке концепции «культурной государственности».

Мақолада давлат ижтимоий соҳасининг белгиланган қуйи тизимлари контекстида Ўзбекистонда фуқаролик жамияти ва ҳуқуқий давлатни, шунингдек, Ўзбекистондаги ҳуқуқий давлатчиликни, уларнинг бир-бири билан муносабатларини тушунишнинг айрим масалалари кўриб чиқилади. Миллий фанда етарлича ўрганилмаган “маданий давлатчилик” тушунчасининг асосий мазмуни таҳлил қилинади.

The article deals with certain issues of understanding civil society and the rule of law in Uzbekistan, as well as legal statehood in Uzbekistan, their relationship with each other, in the context of the designated subsystems of the social sphere of the state. The main content of the concepts of “cultural statehood” that have not been sufficiently studied in national science is analyzed.
ВОПРОСЫ ДЕМОКРАТИЗАЦИИ ГЛОБАЛЬНОГО УПРАВЛЕНИЯ
Authors: Абдулбоки Б.
Published: April 2023

В статье исследуются теоретические и практические аспекты феномена глобального управления и утверждается, что глобализация как социально-политическое явление является современной фазой капитализма. Раскрываются сущность и тенденции возникновения и развития глобального капитализма, анализируются причины его возникновения, степень распространения и отличия от старого капитализма. Устанавливается, что современный глобальный этап капитализма и глобального управления страдает от дефицита демократии, и предлагаются альтернативные пути развития.

Мақолада глобал бошқарувнинг назарий ва амалий жиҳатлари кўриб чиқилган ҳамда глобаллашув ижтимоий-сиёсий ҳодиса сифатида капитализмнинг замонавий босқичи экани таъкидланган. Жаҳон капитализмининг пайдо бўлиши ва ривожланишининг моҳияти ҳамда тенденциялари ёритилган, унинг пайдо бўлиш сабаблари, тавсифи, тарқалиш кўлами ва эски капитализмдан фарқли жиҳатлари таҳлил қилинган. Капитализмнинг ҳозирги глобал босқичи ва бугунги глобал бошқарув тизими демократия етишмаслигидан азият чекаётгани асослантирилган ва ривожланишнинг муқобил йўллари таклиф қилинган.

The article examines the theoretical and practical aspects of the phenomenon of global governance and argues that globalization as a socio-political phenomenon is the modern phase of capitalism. The essence and tendencies of the emergence and development of global capitalism are revealed, the reasons for its emergence, description, extent of distribution and differences from the old capitalism are analyzed. It is argued, that the current global stage of capitalism and global governance system suffer from the lack of democratic principles and suggests alternative ways of development.
ГРАЖДАНСКОЕ ОБЩЕСТВО В РЕСПУБЛИКЕ УЗБЕКИСТАН: СОСТОЯНИЕ И ПЕРСПЕКТИВЫ РАЗВИТИЯ
Authors: Отабек Н.
Published: April 2023

В статье анализируются процесс создания Общественной палаты, ее задачи в поддержке развития институтов гражданского общества в Узбекистане, осуществленные масштабные общественно-политические, социально-экономические, судебно-правовые, демократические реформы и преобразования в стране.

Мақолада Жамоатчилик палатасининг ташкил этилиши, унинг Ўзбекистонда фуқаролик жамияти институтларини ривожлантириш, шунингдек мамлакатда амалга оширилаётган кенг кўламли ижтимоий, сиёсий, иқтисодий, ҳуқуқий, демократик ислоҳотлар ва ўзгаришларни қўллаб-қувватлашга доир вазифалари таҳлил қилинган.

The article analyzes the creation of the Public Chamber, its tasks in supporting the development of civil society institutions in Uzbekistan, the large-scale socio-political, socio-economic, judicial, legal, democratic reforms and transformations carried out in the country.
Comparing Responses to Climate-related Security Risks Among the EU, NATO and the OSCE
Authors: Barnhoorn Anniek
Published: April 2023

This SIPRI Policy Report compares responses to climate-related security risks by the European Union (EU), the North Atlantic Treaty Organization (NATO) and the Organization for Security and Co-operation in Europe (OSCE). All three organizations have formulated ambitious policies in this area in recent years. However, while they have come a long way in raising the interlinkages between climate, peace and security on their agendas, more is required to achieve their various ambitions. This paper recommends three ways forward for policymakers: (a) enhance cooperation between relevant European regional organizations; (b) increase leadership from member states, including through dedicated bodies; and (c) strengthen financial instruments aimed at supporting responses to climate-related security risks.
Gospodarka odpadami komunalnymi w gminie Skrzyszów
Authors: Kolak Tomasz , Maj-Zajezierska Katarzyna
Published: April 2023

W artykule przeanalizowano system gospodarki odpadami komunalnymi w gminie wiejskiej Skrzyszów w latach 2016–2102. Analiza została opracowana na podstawie rocznych sprawozdań tworzonych i publikowanych przez Urząd Gminy. Analiza wykazała, że system selektywnej zbiórki odpadów funkcjonuje prawidłowo oraz mieszkańcy oddają odpady komunalne w PSZOK Pogórska Wola. Co roku wzrasta masa odpadów komunalnych wytworzonych przez mieszkańca gminy Skrzyszów, w roku 2021 wyniosła 309 kg. Analiza frakcji odpadów komunalnych odbieranych z gospodarstw domowych wykazała, że największy udział masowy mają odpady biodegradowalne, wielkogabarytowe oraz opakowania szklane. Podobnie dominującą frakcją wśród odpadów komunalnych oddawanych do PSZOK były odpady gabarytowe, zwłaszcza zużyte opony. Gmina Skrzyszów osiągnęła założone poziomy recyklingu odpadów biodegradowalnych, odpadów budowlanych oraz odpadów papieru, metali, tworzyw sztucznych i szkła określone w Planie Gospodarki Odpadami dla Województwa Małopolskiego na lata 2016–2022.
Review and comparison of methods for limiting leakage currents in single-phase transformerless PV inverter topologies
Authors: Kołodziejski Wojciech , Jasielski Jacek , Kuta Stanisław W. , Szerszeń Grzegorz , Machowski Witold
Published: April 2023

Transformerless inverters are widely used in different photovoltaic nonisolated ac module applications, mainly in grid-tied photovoltaic (PV) generation systems, due to the benefits of achieving high efficiency over a wide load range, and low cost. Various transformerless inverter topologies have been proposed to meet the safety requirement of low ground leakage currents, such as specified in the VDE-4105 standard and low-output ac-current distortion. Topology modifications of transformerless full bridge inverters are designed to balance and maintain a constant common mode output voltage, thereby eliminating or reducing leakage currents. This article reviews and compares the different methods for limiting leakage currents in known topologies of the full-bridge transformerless inverters, such as: H4, H5, H6, HERIC, and their improvements. The main topologies and strategies used to reduce the leakage current in transformerless schemes are summarized, highlighting advantages and disadvantages and establishing points of comparison with similar topologies. To compare the properties of different medium to high power inverters, PV inverter topologies were implemented using IGBTs and tested with the same components, same simulation parameters in PSPICE to evaluate their performance in terms of energy efficiency and leakage current characteristics. The detailed power stage operating principles, extended PWM modulator, and integrated universal gate driver with galvanic isolation in the transmission path of control signal for all IGBTs of the inverter, as well isolated and floating bias power supply for gate drivers are described.
Making sustainable finance taxonomies work for the circular economy: Lessons from the EU Taxonomy
Authors: Barrie Jack , Schröder Patrick , Sherman Suzannah
Published: April 2023

Circular economy initiatives face a significant gap in the availability of finance. Annual worldwide circular economy spending by the corporate sector is estimated at around $850 billion, compared with $35 trillion spent on existing ‘linear’ economic models. Awareness of the circular economy among investors and in the financial sector generally is still low, and there is a lack of tools available with which to define and measure those activities that substantially contribute to the circular economy transition, as well as the investment opportunities and risks associated with those activities. Sustainable finance taxonomies – i.e. shared classification systems for defining environmentally sustainable investments – could help unlock the additional investment needed. The EU’s Sustainable Finance Taxonomy is the most ambitious and comprehensive existing taxonomy, and includes the transition to a circular economy as one of its key objectives. This research paper presents a detailed case study of the EU Taxonomy and identifies the unique challenges associated with embedding the circular economy, with the aim of informing the development of similar taxonomies elsewhere.
Navigating the regionalization of Ethiopia’s Tigray conflict
Authors: Abate Demissie Abel
Published: April 2023

Although fighting in Ethiopia’s Tigray region ceased following the Pretoria agreement of November 2022, peace remains tenuous and spillover conflicts persist in other regions of the country. The war in Tigray has blighted many aspects of Ethiopia’s economy and social fabric, disrupting intercommunal relationships and causing widespread insecurity and humanitarian crisis in the north. Ethiopia has historically maintained a pre-eminent position in the Horn of Africa region, but the conflict significantly impaired and complicated its relations with regional and international partners. Evolving conflict dynamics across northern Ethiopia, newly erupted conflict in Sudan (from April 2023), and the vested interests of neighbouring states risk significantly derailing the peace process outlined in Pretoria and subsequently in Nairobi. Based on key informant interviews and incorporating a wealth of information on the geopolitics of the Horn of Africa region, this paper identifies opportunities for Ethiopia to leverage its external relationships to strengthen regional mediation mechanisms and secure sustainable peace in northern Ethiopia, in line with the arrangements agreed in Pretoria.
Nano-photonics in cancer therapy
Authors: Venkatesh D. Nagasamy
Published: April 2023

Biological alterations result in unchecked cell growth and division producing cancer. Mankind has always been interested in light, and, it being both a topic of study and a device for looking into other occurrences can be seen following the inception of time. Besides the development of nanosystems, the usage of light has now entered a new level where interactions between light and matter occur at wavelength and subwavelength levels accompanying management by physico-chemical properties of nanoforms. This area of nanophotonics enables the investigation and control of lightencompassing nanoforms, individual molecules, and biomolecular assemblies. Numerous molecular cancer treatments have been developed using the amazing nanoscale features as a result of nanophotonics in biomolecular interactivities, or nanobiophotonics. In this work, we demonstrate the applications of nanobiophotonics and of multifaceted nanoplatforms which constitute excellent treatment efficiency and impart breakthroughs for aimed tumour treatment
The effect of the concept of modified unaffected-side active treatment on the gaits of patients with central nervous system damage
Authors: Lee Jung-Ho
Published: April 2023

This study was conducted to investigate the effects of unaffected-side active treatment on the gait of hemiplegic patients. The study subjects were 20 patients who showed hemiplegic symptoms after a stroke. Through a random classification method, the subjects were divided into an experimental group (n = 10) who underwent treadmill exercise based on the concept of unaffected-side active treatment to strengthen the paretic side lower extremity after proprioceptive neuromuscular facilitation (PNF) treatment and a control group (n = 10) who underwent general treadmill training without unaffected side-active treatment after PNF treatment. The therapeutic interventions were performed three times a week for 4 weeks. To analyze behavioural motor motions, the patient's gait speeds and ankle angles were measured using the timed up-and-go (TUG) and the Dartfish program before treatment and 14 and 28 days after beginning treatment. The study results showed that the TUG and ankle angles significantly differed between the experimental and control groups at 14 and 28 days after beginning treatment. These significant differences between the two groups were verified. In conclusion, a lower limb strengthening treadmill exercise based on unaffected-side active treatment can increase gait speed and ankle angle by improving motor control ability
Predicting, designing, characterization and evaluation of a new novel anticancer peptide SSVAM-9 against the lung carcinoma, an insilico approach
Authors: Palanimuthu Vasanth Raj
Published: April 2023

Several anticancer drugs are getting resisted by the cancer cell and treatment like chemotherapy, radiation causes serious side effects. In immunomodulatory treatment the efficiency is less and CAR-T cells, CAR-NK cells require enormous time to get adopt to the in vitro and may cause seizures, dilemma, concussion in prolonged use against the cancer. Even the production of CAR-T cells and NK cells are tedious process. To overcome this situation, anticancer peptides can be used, as they don’t have any drug resistance and they can be highly potent, with good cell penetration. The advantages of these peptides are easy to modify, produce and formulate. This pandemic showed us that, identifying and characterizing a novel anticancer peptide (ACP) is an extremely time and labor consuming process. To reduce the time and labor, this study uses several in silico tools and algorithms like SVM, RF, XGBoost and KNN to predict a novel anticancer peptide. After several studies, with the collected data, a novel anticancer peptide – SSVAM-9 was predicted, which acts against the lung carcinoma. In this, anticancer activity prediction, cell permeation prediction with all 4 algorithms; stability prediction, allergenicity prediction and activity on lung carcinoma prediction were carried out in in silico model. Considering all the parameters, one best novel ACP was selected (SSVAM-9), and it can be easily formulated as the peptide is a stable one. This approach is an advantageous one as it is cost efficient and less-time consuming which can be studied in vivo and in vitro in future.
ẢNH HƯỞNG CỦA BSISO ĐẾN MƯA CỰC TRỊ Ở VIỆT NAM
Authors: Công Thanh  , Bùi Công Minh
Published: April 2023

Các yếu tố tác động đến sự thay đổi lượng mưa ở Việt Nam rất phức tạp và chúng có tác động đáng kể đến các hoạt động phát triển kinh tế - xã hội. Sự biến đổi các yếu tố khí tượng giữa các năm đã được nghiên cứu rộng rãi, nhưng tương đối ít nghiên cứu tập trung vào sự biến đổi theo mùa về lượng mưa, mặc dù sự biến đổi này có thể rất quan trọng đối với các hoạt động nông nghiệp. Trong nghiên cứu này, chúng tôi xem xét tác động của chỉ số dao động trong mùa hè (BSISO) đối với sự thay đổi lượng mưa ở Việt Nam (tháng 6 đến tháng 10). Kết quả nghiên cứu chỉ ra cực trị mưa tăng tại vùng Bắc Trung Bộ (BTB) và vùng Tây Nguyên Nam Bộ (TNNB) trong pha 4 đến pha 6 của BSISO-1, vùng Bắc Bộ (BB) tăng ở pha 3 và 4. Trong pha 1 và 2 của BSISO-2, mưa cực trị ở vùng BTB và vùng TNNB tăng, vùng BB có xác suất tăng không đáng kể.
A Study on the Impact of Various Motor Fitness Characteristics on Performing Ability in High and Low-Performing Divisional Women Cricket Players
Authors: Boby Farjana Akter
Published: April 2023

Background: Motor fitness has a big impact on the cricket performance pyramid.
Objectives: The research concentrates on certain motor fitness components to improve playing competency in both high- and low-performing Divisional women cricket players.
Methods: For this study, 36 female players were randomly selected as subjects from the Bangladesh Women's National Cricket League held in Sylhet in 2022-23. They ranged in age from 16 to 27 years. Three equal groups of twelve people each were formed from the chosen subjects. Khulna, Sylhet, and Dhaka teams were represented by Group I, Group II, and Group III, respectively. Regular exercises and training were provided to enhance the player's performance in the game. Our research scholar additionally prepared the questionnaires with the help of the literature review. The researcher reported the following motor fitness factors: explosive leg power, speed, agility, and cardiovascular endurance. The generated data were gathered during the competition and statistically evaluated after the competition by applying ANOVA and Post Hoc Test (Tukey HSD). The researcher used the statistical software package SPSS version 26 for data analysis.
Results: The results of the study showed that there were significant differences in motor fitness characteristics between high and low-performing Divisional women cricket players. High-performing players had significantly better scores on cardiovascular endurance (p=.000), explosive leg power (p=.013), speed (p=.002), and agility (p=.000) than low-performing players. The Champion Team (Sylhet) of the league was discovered to be more successful than other teams in achieving high-level performance.
Conclusion The study concluded that to execute the best gaming plan, playing skill exclusively depends on physical condition and a stress-free mind. The study highlights the importance of motor fitness characteristics in cricket performance. The findings may have implications for developing training programs tailored to improve specific motor fitness characteristics for players at different performance levels.
Recenzja podrcznika prawniczego: Gertruda Uciska PRAWO UBEZPIECZE SPOECZNYCH. ZASADY, FINANSOWANIE, ORGANIZACJA.
Authors: Wiśniewski Zenon
Published: April 2023

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The Role of the Financial Services Authority in Supervising Capital Market Flows in Indonesia
Authors: Hidayat Defril , Aji Ari Bakti Windi , Aziz Muhammad Ibrahim
Published: April 2023

This study aims to examine the enforcement of laws and the role of the Financial Services Authority in addressing capital market violations amid the development of economic flows in Indonesia. This study uses normative legal research with the statute and comparative approaches. The collected legal material is then qualitatively analyzed to describe the problem and answer study purposes. The results show that capital market violations consist of administrative violations and criminal offenses. Meanwhile, Bapepam’s role in addressing capital market violations has been shifted to the Financial Services Authority. OJK is a builder, regulator, and supervisor of capital market activities. In executing its law enforcement functions, OJK also has the authority to examine, impose administrative sanctions, and investigate criminal offenses to be pursued and resolved through the criminal justice system. On the other hand, based on the una via principle, OJK can also decide not to proceed to the investigation stage of an alleged criminal offense by imposing an administrative sanction in the form of a fine accompanied by a written order. In carrying out its enforcement functions, OJK enforces criminal law both preventively and repressively. Therefore, it is recommended that the OJK and relevant parties enhance coordination and collaboration in enforcing capital market laws, both preventively and repressively. This enforcement can be achieved by improving human resources capacity and infrastructure to monitor daily capital market activities. Increasing investor education and awareness is also crucial to reduce the likelihood of violations. Lastly, OJK should ensure a balanced approach between preventive and repressive law enforcement, considering the una via principle in specific cases. Implementing these recommendations will support creating a conducive, transparent, and fair capital market environment, ultimately attracting investors and further promoting Indonesia’s economic growth.
16. YÜZYILDA İSTANBUL KARAİ CEMAATİ
Authors: TANINMIŞ Vesile
Published: April 2023

Karailik, esasları 8. yüzyılda Irak’ta şekillenen bir Yahudi mezhebidir. Bu mezhebin en karakteristik özelliği, Yahudi sözlü geleneğini reddetmesi ve inanç ilkelerini yalnızca Tevrat’a dayandırmasıdır. Bu yönüyle Yahudiliğin Rabbani kanadına muhalif akımı temsil eden Karailik, göçlerle birçok coğrafyaya dağılmış ve mezhep, Bizans ülkesinde de yayılma fırsatı bulmuştur. Bizans başkenti İstanbul’a yerleşen Karailer, şehrin Osmanlılar tarafından fethi sonrasında varlıklarını devam ettirmişlerdir. Özellikle, II. Mehmet’in uygulamaya koyduğu sürgün politikası ile şehirdeki Karai nüfusu artış göstermiştir. Çalışmamızda, arşiv vesikalarının rehberliğinde, Karai cemaatinin 16. yüzyıldaki yaşamı ele alınmıştır. Bu çerçevede istifade ettiğimiz tahrir defterleri, şehrin Yahudi cemaatlerine ilişkin mühim veriler içermektedir. Döneme ait tahrir defterleri ışığında, İstanbul Karai cemaatinin nüfusu, cemaat mensuplarının ödemekle yükümlü oldukları vergiler, gelir seviyeleri, icra edilen meslekler ve yerleşim alanları değerlendirilmiştir.
Los aspectos legales de la administración del recurso hídrico en Haití
Authors: Giai Marcos
Published: April 2023

El artículo contribuye al conocimiento sobre los aspectos legales de la administración del recurso hídrico en la Republica de Haití. Focalizado en la evolución legal de la gestión del recurso hídrico desde comienzos del siglo XX hasta la actualidad y en simetría con los cambios políticos e institucionales de dicha nación caribeña y delimitado al recurso agua potable y saneamiento. Se adoptó una metodología cualitativa basada en la propia experiencia en terreno, el análisis los instrumentos de política pública y en el proceso de modernización del Estado para la gestión eficiente de los recursos.
POLITICAL UNSTEADINESS AND ECONOMIC RETARDATION IN PAKISTAN
Authors: Shakoor Aqil
Published: April 2023

This study aims to investigate the association between uncertainty in politics and economic retardation in Pakistan, which has been grappling with various political and economic obstacles, such as corruption, frequent government changes, and inadequate investments in infrastructure and human capital. The study utilizes a qualitative methodology and examines secondary data sources, including academic publications, government reports, and international organization reports. A thematic analysis approach is employed to identify the key themes and patterns associated with political uncertainty and retardation in economic activities in Pakistan. The research findings indicate that political uncertainty has a considerable negative impact on the growth of economic activities in Pakistan. Frequent changes in government and a lack of accountability have caused corruption, poor resource management, and a dearth of investment in infrastructure and human capital, resulting in a stagnant economy, high unemployment, poverty, and fewer opportunities for vulnerable populations. The study suggests that several potential solutions can help promote economic growth and stability in Pakistan, including strengthening institutions and governance, promoting economic opportunities, prioritizing human capital development and education, and establishing social protection programs. The implementation of these solutions necessitates long-term commitment and sustained efforts from policymakers, civil society organizations, and the private sector. The research concludes by highlighting the research's limitations and the requirement for further investigation to deepen understanding of the challenges faced by Pakistan. However, the study's findings and recommendations provide critical insights into the relationship between uncertainty in politics and retardation in economic activities in Pakistan, offering potential solutions to enhance the growth of economic activities and stability in the country.
PROSPECTS OF CPEC AND ECONOMIC AND SOCIAL SUSTAINABILITY IN PAKISTAN
Authors: Hussain Arif
Published: April 2023

This paper gives a far-extensive examination of the China-Pakistan Economic Corridor (CPEC) and its possible effect on monetary and social sustainability in Pakistan. Through an analysis of the literature, it assesses the potential open doors and difficulties related to the task, like administration and institutional plans, ecological supportability, social and monetary effect, and international dangers. Furthermore, the paper presents suggestions to work on the possibilities of CPEC and sustainability in Pakistan, including strengthening governance and institutional arrangements, addressing environmental sustainability, ensuring social and economic impact, managing geopolitical risks, and enhancing research and monitoring. The study concluded that while CPEC has the potential for critical financial development and improvement, careful planning and management are necessary to ensure sustainable development and poverty reduction. It recognizes limits in the concentrate like information, time, extension, and predisposition, and prescribes regions for future exploration to fill these gaps. So, this study adds to the continuous discussion on CPEC's advantages and difficulties and its effect on financial and social development in Pakistan.
Mapeo de literatura sobre competencias investigativas en educación. Un análisis bibliométrico
Authors: Romero Sandoval Adriana
Published: April 2023

La investigación ha sido considerada como una de las funciones sustantivas en la educación superior. Todo estudiante debe hacer una investigación en algún momento de su carrera. La educación tomó un giro importante a partir de la pandemia. Existen estudios sobre competencias investigativas, queremos saber dónde se concentran estos estudios y en qué área del conocimiento se explora, a partir de estos resultados, conocer cuáles son esas competencias investigativas que los estudiantes deben desarrollar. Se trabajó con el paradigma cualitativo. El método de estudio fue la bibliometría sobre competencias investigativas en educación, reflejadas en publicaciones científicas desde los años 2000 a 2022 y análisis de narrativa. Con un análisis de frecuencias de las competencias investigativas generales o básicas se encontró que Estados Unidos es el país con mayor cantidad de documentos publicados, la mayoría de los documentos están en revistas ubicadas en cuartil uno, el área de conocimiento que más publicaciones tiene sobre este tema es Salud y Vida, seguido por Tecnología y Ciencias Sociales. La narrativa mostró que se necesita desarrollar habilidades de aprendizaje como el pensamiento crítico, la resolución de problemas, la comunicación escrita, analizar y comprender los datos, evaluar la credibilidad de diversas fuentes de información. A medida que aumenta la difusión de las competencias investigativas, crecen la concienciación y las probabilidades de formar más y mejores investigadores en América Latina.
Estrategias de afrontamiento y resiliencia en cuidadores de la ciudad de Quito
Authors: Morales Fonseca Cristhian Fabricio , Villacís Jácome Juan Enrique , Jurado Mendoza Diana Elizabeth , Gabela Acurio Edison Santiago
Published: April 2023

Se realizó una investigación con el objetivo de identificar las estrategias de afrontamiento y el nivel de resiliencia en cuidadores formales e informales en una institución de salud en la ciudad de Quito. Fue una investigación cuantitativa, no experimental y descriptiva; muestra de 40 cuidadores. Los instrumentos fueron un cuestionario Sociodemográfico, cuestionario de Salud General, inventario COPE-28 de estrategias de afrontamiento, cuestionario de Apoyo Social MOS y escala Bief Resilence. En los resultados se evidencio que los cuidadores emplean estrategias de afrontamiento adecuadas y cuentan con apoyo social, pero el 45% presenta síntomas de ansiedad, y el 72.5% tiene un nivel medio de resiliencia.
Impact of Macro Factors on Stock Market Capitalization
Authors: Lai Cao Mai Phuong  , Tran Thi Quynh  , Ho Le Tuong Vi  , Dinh Thi Kim Truc
Published: April 2023

This article studies the impact of macro factors on the market capitalization of countries around the world. The study uses inflation, interest rates, exchange rates, GDP growth and foreign direct investment as a proxy for macroeconomic factors. Data for all variables are collected for the period 2008-2019. Estimation methods for the balanced panel data are used in this study. The results from the generalized method of moments (GMM) show that inflation, interest rates and foreign direct investment are important factors that significantly affect the capitalization of the stock market. The higher the net foreign direct investment capital, the more support for the development of the stock market. Conversely, higher inflation and interest rates will hinder stock market development in these countries. In addition, the study results confirm that developed stock markets have significantly higher capitalization values than the rest.
Foreign Investor Trading and Stock Market Stability: Evidence from VN30
Authors: Nguyen Thi Nhung  , Anh Dinh Thi Quynh , Pham The Thanh
Published: April 2023

This paper aims to investigate the extent to which foreign investors’ net trading value impacts on the stability of the Vietnamese stock market. By using the vector error correction model (VECM) approach, and a time series of 30 stocks listed on the VN30 which are collected from Fiinpro over the period from February 2012 to September 2022, the research provides evidence of the positive impact of foreigners’ net trading value on the stability of the Vietnamese stock market, with a positive impact on stock market liquidity and a negative influence on stock market volatility in the short-term. However, there is no evidence of a long-term relationship between foreigners’ net trading value and the volatility or liquidity of the Vietnamese stock market. In addition, the research proposes several implications for policy makers which could enable them to make appropriate adjustments to regulations on foreign investor trading, in order to ensure the stability of the Vietnamese stock market in the future, as well as for both individual and institutional investors who can use foreign investor trading as a sign of the stock market stability to make decisions.