bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Konseling Kelompok Menggunakan Pendekatan Cognitive Behavior Therapy untuk Meningkatkan Kontrol Diri Siswa
Authors: Hardi Emeliya , Ermayulis Desi , Masril Masril
Published: October 2021

The main problem in this study is the lack of self-control of students in class XI IPS SMAN 1 Batipuh. The purpose of this study was to see how much influence the group counseling approach to Cognitive Behavior Therapy to improve self-control of students of class XI IPS SMAN 1 Batipuh. This type of research is quantitative research using experimental methods. The design used in this study was pre-experimental design with the type of one group pretest-posttest design, namely by measuring the self-control of the experimental group students by using the same instrument in the pretest and posttest measurements. The population in this study were all students of class XI IPS SMAN 1 Batipuh, the sample in this study were 10 students who have low self-control. The results showed that cognitive behavior therapy approach group counseling had a significant effect on student self control. This can be seen based on the results of "t" count with df or db 9, with a significance level of 0.5% obtained that (16.8)> tt (1.83) can thus be interpreted that the cognitive behavior therapy approach group counseling influential significant to the self-control of students of class XI IPS at SMAN 1 Batipuh
Penerapan Perilaku Altruistik dalam Layanan Konseling Individu Oleh Guru Bimbingan dan Konseling di Sekolah
Authors: Yandri Hengki , Fikri Moh Kamil , Juliawati Dosi
Published: October 2021

Penelitian ini dilatarbelakangi oleh adanya indikasi guru BK di sekolah dalam melaksanakan layanan konseling individu belum memperlihatkan perilaku altruistik. Tujuan penelitian ini yaitu untuk mengungkapkan tingkat penerapan perilaku altuistik dalam layanan konseling individu oleh guru BK di sekolah menggunakan penelitian kuantitatif deskriptif dengan jumlah responden sebanyak 74 orang yang pernah mendapatkan layanan konseling individu dari guru BK. Hasil peneltian ini mengungkapkan bahwa rata-rata tingkat penerapan perilaku altruistik guru BK dalam melaksanakan layanan konseling individu berada pada kategori sedang
Quality of Service Packet Loss Pada Sistem Home Monitoring Water Flow Berbasis Internet of Things
Authors: Pratama Andree Fajar , Baqaruzi Syamsyarief , Muhtar Ali
Published: October 2021

Perilaku boros air bersih menyebabkan semakin banyak orang yang kehilangan akses terhadap air bersih. Penggunaan air di dalam rumah tangga selama ini masih sangat sulit untuk dilakukan pengelolaan dalam penggunaan air secara efektif. Kelangkaan air bersih adalah situasi saat terjadinya kekurangan air untuk memenuhi kebutuhan manusia. Penelitian ini menmbangun sistem Home Water Flow Monitoring (HEROIG) berbasis Internet of Things (IoT) untuk melakukan monitoring dan controlling penggunaan air pada rumah. Perangkat keras menggunakan NodeMCU sebagai mikrokontroler serta mengirimkan hasil sensing debit air oleh sensor water flow yang akan dikirimkan ke cloud server. Pengontrolan dapat dilakukan melalui aplikasi android HEROIG yang telah dibuat dan terintegrasi dengan sistem IoT yang harus bekerja dalam koneksi jaringan yang baik. Pengujian kualitas koneksi jaringan atau Quality of Services (QoS) khususnya packet loss menggunakan dua parameter yaitu dari waktu dan jarak. Hasil pengujian packet loss parameter waktu dengan pengujian enam detik sekali dalam waktu satu menit memiliki nilai rata-rata packet loss 1,13%, kemudian untuk pengujian parameter jarak dengan selisih setiap jarak adalah empat meter memiliki nilai rata-rata packet loss 0,15%. Hasil pengujian tersebut menunjukan kualitas pengiriman data sensor ke cloud server memiliki parameter QoS packet loss kategori sangat baik, karena memiliki nilai packet loss <3%.
PENGARUH PARTISIPASI ANGGOTA DAN LINGKUNGAN KERJA TERHADAP KEBERHASILAN USAHA KOPERASI KARYA KITA DI SEKRETARIAT DEWAN PIMPINAN PUSAT PARTAI GOLONGAN KARYA
Authors: Sugina Sugina , Sunarya Po Abas , Khairul Khairul
Published: October 2021

Penelitian ini bertujuan untuk menguji pengaruh partisipasi anggota dan lingkungan kerja secara parsial maupun secara simultan terhadap keberhasilan usaha Koperasi Karya Kita di Sekretariat DPP Partai Golkar, populasi berasal dari Koperasi Karya Kita Sekretariat DPP Partai Golkar dengan metode sampel jenuh sebanyak 62 responden, metode penelitian yang digunakan adalah metode survey secara deskriptif berjenis penelitian kuantitatif, dengan analisis data pengujian validitas dan reliabilitas, uji normalitas dan pengujian regresi sederhana dan regresi berganda meliputi uji model summary, coefficient dan uji anova. Hasil penelitian menunjukkan bahwaterbukti terdapat pengaruh secara simultan Partisipasi Anggota (X1) dan Lingkungan Kerja (X2) terhadap Keberhasilan Usaha Koperasi (Y) berdasarkan nilai t hitung 6.991 > 2.00030 secara signifikan 0.000 < 0.05, terbukti bahwa terdapat pengaruh Partisipasi Anggota (X1) terhadap Keberhasilan Usaha Koperasi (Y) berdasarkan model summary senilai 0,510 atau 26,01% sedangkan sisanya 73,9% dipengaruhi variable lainnya yang tidak diteliti, terbukti bahwa terdapat pengaruh lingkungan kerja (X2) terhadap keberhasilan usaha koperasi (Y) berdasarkan model summary senilai 0,330 atau 10,89% sedangkan sisanya 80,91% dipengaruhi variable lainnya yang tidak diteliti dan terbukti bahwa terdapat pengaruh partisipasi anggota (X1) dan lingkungan kerja (X2) secara simultan terhadap keberhasilan usaha koperasi (Y) berdasarkan model summary senilai 0,870 atau 75,69% sedangkan sisanya 24,31% dipengaruhi variable lainnya yang tidak diteliti
Pemanfaatan Film Sebagai Peningkatan Media Promosi Pada Tempat Wisata
Authors: Desrianti Dewi Immaniar , Supriati Ruli , Herdiana Kivti
Published: October 2021

Perkembangan zaman saat ini berpengaruh terhadap berkembang nya teknologi informasi dan komunikasi. Salah satu media pendukung untuk menyampaikan informasi yang efektif yaitu media promosi. Saat ini banyak tempat – tempat wisata yang memanfaatkan Film sebagai media promosi. Film saat ini banyak digemari oleh kalangan manapun karena Film menampilkan penyampaian cerita yang berbentuk audiovisual dan memiliki makna atau arti serta dikemas dengan teknik sinematografi yang indah dan menarik. Permasalahannya adalah dalam menginformasikan dan mempromosikan Wisata Alam Sevillage ini hanya menggunakan media cetak seperti brosur, pamflet keterangan harga tiket, nameboard dan foto-foto yang diunggah ke sosial media Wisata Alam Sevillage, sehingga diperlukan pemanfaatan Film untuk peningkatan media promosi pada Wisata Alam Sevillage. Tujuan penelitian ini adalah untuk membantu pihak pengelola dalam peningkatan media promosi untuk menarik minat berkunjung ke Wisata Alam Sevillage melalui strategi promosi pada sosial media Facebook, Instagram, Youtube, dan promosi ke relasi. Manfaat penelitian ini yaitu melalui Film ini, Wisata Alam Sevillage dapat meningkatkan jumlah wisatawan lokal maupun mancanegara yang berkunjung, serta meningkatkan pencapaian target pemasaran. Metode penelitiannya yaitu, Pengumpulan Data, Analisa SWOT, Analisa Perancangan Media dan Konsep Produksi Media (KPM). Hasil dari penelitian ini nanti nya akan diimplementasikan ke media sosial seperti Facebook, Instagram dan Youtube untuk membantu mempromosikan Wisata Alam.
Video Penyuluhan Hama Tanaman Dan Pengenalan Pestisida Produksi PT. CBA Mitra Petani Oleh PT. Anugerah Creative Media
Authors: Andwiyan Denny , Wulandari Ria , Prasetyo Alam Putra
Published: October 2021

Pada era globalisasi dunia, dibutuhkan strategi pemasaran yang baik, sehingga dapat menjangkau luasnya target pemasaran dari yang sebelumnya. PT. Anugerah Creative Media berlokasi di Tangerang Selatan ini bergerak dibidang creative. Perusahaan ini membutuhkan sebuah media implementasi guna membantu project kerjasama dengan klien PT. CBA Mitra yang membutuhkan sebuah video sebagai media penyuluhan hama tanaman bagi para petani. Permasalahannya adalah, saat ini PT. CBA Mitra masih memanfaatkan video penyuluhan yang sederhana. Observasi ini bertujuan untuk memberikan informasi dan meningkatkan pemasaran produksi PT. CBA Mitra. Manfaatnya yaitu PT. Anugerah Creative Media dapat memberikan promosi dan informasi yang terupdate mengenai PT. CBA Mitra. Penelitian ini melingkupi metode pengumpulan data, SWOT analysis, pengembangan media dan konsep produksi media (KPM), yang didalamnya terdapat pre production, production dan post production, serta meliputi software unggulan yaitu : Adobe Premiere Pro CC 2019, Adobe Audition CC 2019, Adobe After Effect CC 2019 dan Adobe Photoshop CC 2019. Melalui video penyuluhan ini, diharapkan petani atau masyarakat mengetahui informasi hama tanaman dari meningkatnya jumlah produk PT. CBA Mitra.
Breviario sociocultural de sabores serranos
Authors: Vargas-Vizuet Ana Liviere , Morandín-Ahuerma Fabio , Romero-Fernández Abelardo
Published: October 2021

En este trabajo, resultado de un acopio prolongado de experiencias y relatos desde la tradición oral de los pobladores de la Sierra Nororiental de Puebla y regiones vecinas del estado de Veracruz, se hace una recopilación de platillos que constituyen la usanza y costumbres culinarias en la región y que más allá de la práctica nutrimental de los mismos, se pone en evidencia el elemento sociocultural del entorno alimentario de las comunidades que la conforman. Se realizaron entrevistas en profundidad semiestructuradas con personas dispuestas a compartir su conocimiento y vivencias en torno a la atmósfera del platillo, desde su ámbito cotidiano hasta el festivo y ceremonial. El propósito de este trabajo ha sido el de compartir no sólo la gastronomía de la región, sino y, sobre todo, conocer la voz de aquellos que se involucran en la experiencia social y cultural de alimentarse, desde la preparación hasta la degustación, desde el ingrediente secreto hasta su carga simbólica, desde la obtención de los ingredientes hasta el entorno ritual que les hace únicos.
Unconventional Intersection Designs for Improving Traffic Operation Along Arterial Roads
Authors: Hadidi Taqwa , Naghawi Hana , Jadaan Khair
Published: October 2021

The main objective of this paper is to evaluate the effect of implementing four Unconventional Arterial Intersection Designs (UAIDs) including median U-Turn, Superstreet, Jughandle and Single Quadrant Intersection on a major arterial road using SYNCHRO microscopic simulation software. For this purpose, Wadi Saqra Signalized Intersection on Shaker Bin Zaid major arterial road in Amman, Jordan was selected. The simulation results showed that only the Jughandle improved the intersection Level of Service (LOS) slightly, F–E. Nevertheless, the intersection delay was significantly reduced by 64.81%, 76.6%, 91.28% and 75.60% on the proposed Median U-Turn, Superstreet, Jughandle and Single Quadrant unconventional intersection design, respectively. This indicated that these UAIDs don't perform well under heavy traffic volumes. Also, since the Jughandle was the only UAID which improved the LOS on the main intersection, the operational performance of Prince Shaker Bin Zaid arterial after implementing the Jughandle at the main intersection was evaluated including the main intersection: Wadi Saqra intersection, one prior to the main intersection and one after the main intersection. It was found that the use of the Jughandle increased the average travel speed by 35% and decreased the average stopped delay by 28.68% on the arterial road. Also, this paper evaluated the current transportation system and road user's attitude towards UAIDs' implementation through a questionnaire survey. The results indicated high acceptance of UAIDs. Finally, the construction cost for each UAID type was estimated. It was found that the Jughandle had the highest construction cost due to its high acquisition cost.
Jövőt adni az építészeti múltnak : A füzéri Felsővár gazdasági épületszárnyának rekonstrukciója
Authors: Sulyok Miklós
Published: October 2021

Without resorting to sentimentallity or overt trends regarding modernisation of historical monuments the architect responsible for this project was afforded the freedom to create a historically fatihfull reconstruction. This former bakery and archive building has been given a new lease of life, that is forward looking, considers issues of maintenance and usability. This is not a static exhibit, it is a functional building, and reinforces the idea of cultural identity and locality.
Clinical Profile and Outcome of Children with Congenital Heart Disease in First Year of Life
Authors: Rana Rubina Afroz , Khatoon Soofia , Ahmed Mir Nesaruddin , Islam Md Rafiqul , Kabir Shahreen , Das Nanda Lal , Nahar Zakia , Jebunnesa - , Jobayer Mohammad
Published: October 2021

Diagnosis of congenital heart disease (CHD) which is a structural abnormality of the heart or intra thoracic great vessels in the earliest possible time is very important. Identifying the various modes of presentation, early referral and appropriate intervention can save lives and reduce risk of complications. The objectives of this study were to determine the clinical profile, complication and immediate outcome of children with congenital heart disease in first year of life. This cross-sectional observational study was conducted from October 2011 to March 2012 among 50 children from zero to one year of age who was diagnosed as CHD by echocardiography admitted in Department of Paediatrics of ShaheedSuhrawardy Medical College, Dhaka and Department of Paediatric Cardiology of National Institute of Cardiovascular Diseases, Dhaka, Bangladesh. Among 50 infants acyanotic CHD was detected in 70% and cyanotic in 30% infants. Major structural defects were venticularseptal defect 34%, patent ductusarteriosus 30%, tetralogy of fallot’s 14%, transposition of great arteries 12%, atrial septal defect 6%. Presenting features were cough 82%, dyspnea 80%, poor weight gain 70%, feeding difficulty 68% and fever 58%. Frequently observed complications were failure to thrive, pulmonary hypertension and heart failure. Among the outcome of CHD 8% cases closed spontaneously, case fatality rate was 8% and the rest were advised accordingly for surgery, intervention and medical management among which 14% had device closure within the study period. High index of suspicion, early diagnosis, close monitoring and timely intervention can reduce complication of CHD.

Bangladesh Med J. 2020 Sept; 49(3) : 17-21
Obituary News September-2020 Vol.49(3)
Authors: Halim Kazi Shafiqul
Published: October 2021

Abstract not available

Bangladesh Med J. 2020 Sept; 49(3) : 57-63
Morphometry of stingless bees (Hymenoptera:Apidae:Meliponini) of the genus Lisotrigona indicates presence of more than one species in India
Authors: Viraktamath Shashidhar , Jha Ashish Kumar , Rao Shubham , Thangajam Rojeet , Roy Jagruti
Published: October 2021

Morphometry of 53 stingless bees of the genus Lisotrigona collected from seven places in India by using 36 morphological parameters was studied. The data set also included  morphometry data of primary types of L. cacciae, L. chandrai and L. revanai for comparison and was subjected to Factor and Canonical Discriminant analysis. All the bees collected from five places formed two distinct clusters in the Factor analysis and five clusters in Canonical Discriminant analysis. In both the methods of analysis primary types of L. cacciae, L. chandrai and L. revanai were placed well separated from each other as well as from other bees. The bees from seven places also differed from the three known species in morphometry and ratios of length and width of parts of the body. Based on these results it is concluded that Indian stingless bees of the genus Lisotrigona consists of more than one species besides L. cacciae. The action of synonymizing L. mohandasi, L. chandrai and L. revanai with L. cacciae appears arbitrary; these three species should be considered valid until supported by male genital morphology or molecular characters.
Seasonal foraging activity of stingless bee Tetragonula travancorica Shanas and Faseeh (Hymenoptera: Apidae: Meliponini)
Authors: Abraham Lincy , Shanas S.
Published: October 2021

The foraging hive activity of stingless bee Tetragonula travancorica Shanas and Faseeh was studied from November 2018 to August 2019. The activity varied between the seasons, weather conditions and time hours of study. The outgoing and incoming pollen foragers exhibited two peaks in activity, from 0800-1200 h (first) and during 1500-1600 h (second). The activity of incoming non-pollen foragers displayed only one distinct peak between 1000-1200 h except during the southwest monsoon period. The greatest activity was recorded during the dry season (January-May), followed by the south-west monsoon (June-August) and north-east monsoon (November- December) seasons. Maximum overall activity was recorded during hotter months February, March and April while the lowest was observed in January and December. At any season or time, the number of incoming foragers without pollen was greater than pollen foragers.
Compensación reactiva en redes eléctricas de transmisión basado en programación no lineal considerando ubicación óptima de SVC
Authors: Ramirez Jhon
Published: October 2021

El subsistema de transmisión en sistemas eléctrico de potencia es muy importante, debido a que es el encargado de llevar la energía eléctrica desde la generación hasta la etapa de subtransmisión y posteriormente a ser distribuida. Las aplicaciones de los FACTS SVC en las barras del sistema eléctrico de potencia son variadas; estos dispositivos nos permiten modificar el flujo de potencia en el sistema de potencia, con el fin de aprovechar al máximo la capacidad de las líneas de transmisión; el ubicar estos elementos compensadores de potencia reactiva tiene un costo elevado, por lo que es necesario ubicarlos de forma óptima e inteligente, con el fin de hacer que la inversión sea factible. En la presente investigación se presenta una metodología para minimizar la desviación de las magnitudes de los perfiles de voltaje, para lo cual analizamos el comportamiento antes y después de la compensación reactiva en redes de transmisión mediante programación no lineal considerando ubicación óptima de SVC en los modelos de 14 y 30 barras del IEEE (Institute of Electrical and Electronics Engineers). Finalmente, la ubicación de compensadores de potencia reactiva en las barras del SEP mejora los perfiles de voltaje en cada una de sus barras, minimiza costos de inversión y reduce las pérdidas de potencia activa y reactiva en las líneas de transmisión.
Interacción de electrones rápidos con esferas de plata sub-10 nm: resultados recientes
Authors: Campos Alfredo
Published: October 2021

La interacción de electrones rápidos con nanopartículas metálicas ha sido de gran interés científico y tecnológico debido a la posibilidad de explorar las propiedades ópticas de nanopartículas metálicas con resolución espacial sub-nanométrica y espectral en el orden de los meV. Esta combinación de información espacio-espectral es posible gracias a la microscopia electrónica de transmisión de barrido (STEM) junto a un espectrómetro de pérdida de energía de electrones (EELS). Recientemente, diferentes artículos han mostrado estudios EELS en nanoesferas de plata de tamaños inferiores a los 10 nm, dimensión en la cual se esperan efectos cuánticos, reportando resultados contradictorios a los obtenidos en décadas pasadas por la conocida técnica de absorbancia óptica. Esta discrepancia EELS-óptica ha sido tema de debate en los últimos años y en este artículo de revisión mostraremos como este problema se ha venido esclareciendo, considerando la influencia del haz de electrones sobre la interfaz partícula-medio.
Herramientas de infraestructura como código: Ansible, Terrafom, Chef, Puppet
Authors: Dominguez-Quintero Luis , Vargas-Lombardo Miguel
Published: October 2021

Las herramientas de Infraestructura como código (IaC) permiten automatizar las tareas realizadas por los departamentos de IT de forma rápida y dinámica mediante el uso de lenguajes de programación de scripts, que permiten administrar, crear, manipular y distribuir múltiples recursos informáticos a gran escala dentro de una infraestructura de Cloud Computing. Las herramientas de Infraestructura como código Ansible, Terrafom,  Chef, Puppet  generan una representación virtual de toda la infraestructura física y  escalable de una plataforma Cloud Computing y de  Centro de Datos, facilitando  que esta sea programable y dinámica.
Benthic synecology in a soft sediment shelf: habitat contrasts and assembly rules of life strategies
Authors: Beauchard O , Mestdagh S , Koop L , Ysebaert T , Herman PMJ
Published: October 2021

Biological traits of benthic macroinvertebrates from a large area of the North Sea soft sediments were used to explore habitat occupancy within seascapes of contrasting hydrodynamics. The area, the Dutch sector of the North Sea, is mainly composed of 2 habitats: shallow dynamic bottoms of heterogeneous geomorphologies and deep homogeneous muddy bottoms. Higher within-habitat heterogeneity was hypothesized to more specifically select benthic life strategies according to environmental filtering, i.e. through the action of abiotic forces. Functional community patterns were explored through the RLQ method, which relates habitat and trait variables, at different spatial scales of specific seascape heterogeneity, and functional diversity indices were used to shed light on community assembly mechanisms. Locally, 3 associations between habitat characteristics and biological traits were shown to correspond with predictions of life history theories, whereas only 2 emerged when considering all types of seascapes. This spatial scale-dependence was explained by abiotic alternations masked over the larger scale at which all the existing strategies could not be properly disentangled. The relative composition in strategies obeyed specific assembly rules as identified by functional diversity indices. Seascape geomorphology was locally discriminant of functional patterns, and could account for biodiversification, much beyond basic taxonomic counts. Whereas habitats of higher physical stability hosted the taxonomically richest communities, stress or disturbance frequency increased functional variations within communities due to different strategist habitat occupancies. This study proposes a generic mechanism of benthic community structuring in soft sediment shelves.
OPTIMALISASI PERAN TENAGA TEKNIK KEFARMASIAN (TTK) PADA PELAKSANAAN SWAMEDIKASI VITAMIN SEBAGAI PENGUAT SISTEM IMUN DIMASA PANDEMI COVID-19
Authors: Sukmawati Ika Kurnia , Lisni Ida , Hartini Ni Nyoman Mas Dri , Pryadi Akhmad , Yunisa Ed
Published: October 2021

Many people do self-medication to deal with complaints or symptoms of disease by buying drugs at a pharmacy or drug store. Such treatment needs to be carried out appropriately, so that people need clear information in determining the type and amount of drugs to be used rationally and how to use them properly. To be able to increase the understanding of Pharmaceutical Technical Workers in providing self-medicating vitamins as a booster for the immune system during the Covid 19 pandemic, community service was carried out by holding online webinars about vitamin giving material and its classification and characteristics of vitamins, as well as reminding about dosages, indications, side effects and the dangers of overuse of vitamins. In addition, an example video is provided for the provision of vitamin information to help technical understanding of pharmaceutical technical workers in providing drug information services to patients / the public. The webinar was held in two meetings, namely on 19 and 26 September 2020 with presenters being lecturers at the Faculty of Pharmacy, Bhakti Kencana University, to Pharmaceutical Engineering Workers who are members of the JABAR Indonesian Pharmacists Association (PAFI) organization. Community Service Activities through Webinars and screening of vitamin self-medication videos can increase understanding of Pharmaceutical Technical Staff in providing self-medicated vitamins as a booster for the immune system during the Covid 19 pandemic.
PKM KELOMPOK KRR DALAM PENCEGAHAN PERILAKU SEKS PRANIKAH DI MTS TARATE KABUPATEN SUMENEP
Authors: Permatasari Dian , Camalia Hadina Eka , Suprayitno Emdat
Published: October 2021

Reproductive health has the concept that everyone can have a satisfaction and a safe and responsible Sexual life. Therefore it is the right of every youth to be informed and gain access to Seksual and reproductive health true, complete and honest that enables them to make choices and decisions responsible for their reproductive and Sexual health rights. The main objective of reproductive health is to provide reproductive health services comprehensively to each individual and partner, especially to adolescents so that Each individual is able to undergo the reproductive process in a healthy and responsible manner as well as free from discrimination and violence, including recognition and respect for reproductive and Sexual health rights as an integral part of Human Rights. Providing access to education and adolescent reproductive health services is expected to increase the independence of adolescents in regulating functions and processes reproduction, including their Sexual life, so that their reproductive health rights can be fulfilled in improving the quality of life and the quality of their offspring both physically, mentally and social and free from fear, violence and discrimination. The result achieved from this activity is an increase in participants' knowledge about puberty and reproductive health. Specific objectives of the development of the education system and health services Reproduction for adolescents is to protect adolescents from the risk of early marriage, unwanted pregnancies, abortions, Sexually Transmitted Infections (STIs), HIV/AIDS and Sexual violence.
PENGARUH PENAMBAHAN POLIETILEN GLIKOL 6000 PADA TABLET IBUPROFEN DISPERSI PADAT TERHADAP ABSORBSI IBUPROFEN SECARA IN SITU
Authors: Tampubolon Antetti
Published: October 2021

Drug absorption can be decided by various methods, namely in vitro methods, in situ methods, and in vivo methods. The in situ method is a procedure that is very close to the in vivo method. The aim of this study was to identify the effect of accumulation of polyethylene glycol 6000 (PEG 6000) on solid dispersion of ibuprofen tablets on the in-situ absorption of the drug. This research was conducted through an experiment to determine the effect of adding polyethylene glycol 6000 to the absorption of ibuprofen in situ by flowing the solution from solid dispersion ibuprofen tablets, solutions from generic ibuprofen tablets and standard ibuprofen solutions. The solid dispersion system was carried out by melting ibuprofen and polyethylene glycol 6000 in a ratio of 1:05. The drug solution was flowed through the lumen of the small intestine of male rats. Unabsorbed ibuprofen was measured by an ultraviolet spectrophotometer at a wavelength of 225.5 nm. Next, the absorbed level of ibuprofen was calculated. The results showed that ibuprofen from solid dispersion tablets was absorbed more than ibuprofen from generic tablets and standard ibuprofen. It can be concluded that polyethylene glycol 6000 has an effect on the absorption of ibuprofen in situ.
LAJU FILTRASI GLOMERULUS PASIEN DIABETES MELITUS TIPE II DI SALAH SATU RUMAH SAKIT SWASTA DI KABUPATEN DEMAK
Authors: Rukminingsih Fef , Widiastuti Mei
Published: October 2021

Diabetes Mellitus (DM) Type II is a group of metabolic diseases with hyperglycemia characteristics. The use of oral hypoglycemic drugs (OHO) lasts for a relatively long time. Most of the OHO is excreted through the kidneys. This study aims to determine the Glomerulus Filtration Rate (GFR) of type 2 DM patients who use OHO at the "X" Hospital, District of Demak. This study is an observational descriptive study using retrospective data obtained from medical record data (RM) of outpatient JKN participants with type 2 DM for the period October-December 2020. Inclusion criteria were patients who received OHO for at least one year with or without comorbidities, aged 36-65 years, and had a serum creatinine test. Patients receiving combination therapy with insulin were excluded. LFG is calculated using the Cockroft-Gault formula. From 82 patients, 52 patients (62.2%) were female, 74 patients (90.2%) were more than 45 years old. Patients who consumed OHO for more than 2 years were 47 (57.3%). Patients without comorbidities were 62 (75.7%) people. Patients who experienced a decrease in GFR in the moderate category (stage 3) as many as 24 people (29.3%), a decrease in GFR in the severe category (stage 4) as many as 5 people (6.1%) and 1 person (1.2%) experienced End Stage Renal Disease.
Análise do perfil dos orientadores do Programa Institucional de Bolsas de Iniciação Científica (Instituto Federal Goiano – Campus Urutaí – 2011 a 2014)
Authors: Malafaia Guilherme , Lima Géssyca Mendes , Menezes Ivandilson Pessoa Pinto de , Lacerda Priscilla Mendonça de , Pereira Alexandre Igor de Azevedo
Published: October 2021

Este estudo teve como objetivo analisar o perfil de professores orientadores do Programa Institucional de Bolsas de Iniciação Científica (PIBIC) do Instituto Federal Goiano – Câmpus Urutaí, entre os anos de 2011 e 2014. Para isso, coletou-se dados dos orientadores através da Plataforma Lattes do CNPq. Foram coletadas informações sobre titulação, áreas e linhas de atuação, experiência de orientação, produção cientifica, dentre outros. Na sequência, construiu-se um dendrograma baseado no método de agrupamento de Neighbor Joining, o qual permitiu a identificação de três grupos bem distintos, representativos do perfil de professores orientadores (A, B e C). O grupo A (n=17) compreende aquele em que nenhum professor orientador do PIBIC foi estudante de PIBIC/PIVIC em sua instituição de origem e não possui linhas de pesquisa explicitadas em seu currículo Lattes. O grupo B (n=24), representa o maior percentual de professores que foram estudantes de PIBIC/PIVIC, além de possuírem projetos e áreas de atuação cadastradas no currículo Lattes e serem o grupo com maior número de orientações de estudantes concluídas, assim como maior índice de publicação de resumos nos últimos 4 anos. No entanto, esse grupo compreende a menor porcentagem de professores com doutorado (42%). Já o grupo C (n=26) destaca-se por ter o maior percentual de professores com doutorado, sendo também o grupo que menos orientou estudantes em trabalhos de conclusão de curso e em PIBIC/PIVIC. É possível notar, que este grupo compreende, portanto, professores jovens, recém-doutores, cujas publicações possivelmente sejam resultados de pesquisas de seus estudos em programas de pós-graduação ou de estudos independentes, não vinculados ao PIBIC/PIVIC. Em síntese, pôde-se concluir que o perfil dos orientadores analisados é caracterizado por possuir (1) aproximadamente metade de professores que foram estudantes do PIBIC/PIVIC, (2) projetos cadastrados no Lattes, (3) orientadores-doutores, (4) experiência em orientação de iniciação científica e (5) publicação de pelo menos 5 resumos nos últimos 4 anos. Todavia, apenas 35,9% dos orientadores, possuem pelo menos 5 artigos publicados entre os anos de 2011 a 2014.
Governo eletrônico brasileiro: ações de integração entre sistemas de governo e sociedade
Authors: Vieira Gabriel da Silva
Published: October 2021

Ao longo das últimas décadas vimos uma proliferação de sistemas baseados em computador. Notadamente sistemas computacionais de diferentes naturezas estão presentes no cotidiano, em escolas, empresas, governo, entre outros. O desafio atual consiste em tornar essa grande quantidade de sistemas diversos em sistemas computacionais interoperáveis. Com o intuito de promover a integração entre sistemas de governo e sociedade, o governo federal brasileiro vem promovendo ações para que essa integração ocorra. Esse trabalho investiga essas soluções, apresentando padrões definidos, arquiteturas adotadas e mecanismos de oferta e consumo de serviços.
Tendências da produção científica sobre o tráfico de espécies
Authors: Santos Letícia Pereira dos , Araujo Danielle Rodrigues de
Published: October 2021

O objetivo deste trabalho foi avaliar as tendências das pesquisas mundiais sobre o tráfico de espécies por meio de uma análise cienciométrica. Foi realizada uma busca por artigos científicos na base de dados Web of Science, sobre o tema comércio ilegal de espécies, publicadas entre os anos de 1991 a 2012. Foram encontradas 254 publicações, das quais não foi encontrada nenhuma tendência no número de artigos publicados ao longo dos anos. Entretanto publicações sobre temas ecológicos, conservacionistas e genéticos apresentaram aumento temporal. Há ainda uma preocupação dos pesquisadores em verificar os impactos ecológicos e a importância da conservação da biodiversidade, por meio de ferramentas moleculares que permitem a identificação de espécies comercializadas ilegalmente. Além disso, a relação das espécies com o interesse final, pela qual ela é comercializada, pode fornecer importantes dados para contribuir com a fiscalização do comércio ilegal de espécies.
Education and economic growth in Brazil of 2000s
Authors: Ferreira Filipe Possa
Published: October 2021

Brazilian economy was appointed, at the middle 2000s, as a bright promising economy in a global scale. Following the prognostic, Brazil was confirmed as an emergent nation along the years, and even on the harsh period of the international financial crisis of 2008, Brazil still follows his own positive growth path. Among others, some statistics were considerably important to demonstrate Brazil success, such as: GDP, trade balance, consumption, investments and further, launching Brazilian economy on the top 10 largest economies in the world. Despite these positive aspects, the Brazilian education did not follow the same path. While there were improvements in economic-social aspects, such as: reduction of poverty, income equality, social inclusion, housing, sanitation and others, the quality of primarily education did remained in a lower level than world average, according to PISA tests and specialized educational works. These two distinct features contribute to the existence of a paradox between: education and economic growth. The aims of this article is to present the positive and negative aspects of Brazilian economic growth path, pointing out achievements and fails. For then presents a critical view on education system using PISA and others reports. Paradoxically the level of Brazilian education has not become a barrier preventing economic growth, however the gap between education and economic progress would indicate an obstacle ahead. Indeed this will be a necessary challenge to the future of Brazilian government and society.
A modular framework for ontology learning from text in Portuguese
Authors: Guimarães Norton Coelho , De Carvalho Cedric Luiz
Published: October 2021

Research on ontology learning has been carried out in many knowledge areas, especially in Artificial Intelligence. Semi-automatic or automatic ontology learning can contribute to the field of knowledge representation. Many semi-automatic approaches to ontology learning from texts have been proposed. Most of these proposals use natural language processing techniques. This paper describes a computational framework construction for semi-automated ontology learning from texts in Portuguese. Axioms are not treated in this paper. The work described here originated from the Philipp Cimiano’s proposal along with text standardization mechanisms, natural language processing, identification of taxonomic relations and techniques for structuring ontologies. In this work, a case study on public security domain was also done, showing the benefits of the developed computational framework. The result of this case study is an ontology for this area.
Metodologia padronizada para o teste de germinação em sementes de grão-de-bico (Cicer arietinum L.)
Authors: Rosa Marina Rodrigues , Betânia Xavier Dias Letícia , Nascimento Warley Marcos , Fernandes Leão-Araújo Érica
Published: October 2021

O presente trabalho objetivou estabelecer (atualizar) a metodologia para execução do teste de germinação em sementes de grão-de-bico, no que se refere ao substrato, temperatura ideal e data da primeira contagem. Para tanto, foram realizados três ensaios: I) avaliação de substrato; II) avaliação da temperatura de exposição das sementes durante a germinação; e III) averiguação da data de primeira contagem. Os experimentos foram organizados em delineamento inteiramente casualizado, esquema fatorial 6 x 3 (cultivares x substratos), para o ensaio I e 6 x 4 (cultivares x temperatura) para o ensaio II, ao final foram realizadas as análises de variâncias e as médias comparadas pelo teste de LSD. Para o ensaio III foi elaborado gráfico de contagem de plântulas normais, avaliando a porcentagem de germinação. Os parâmetros analisados foram: germinação, índice de velocidade de germinação e tempo médio de germinação, nos ensaios I e II. No ensaio III apenas germinação. Foram observadas maiores porcentagens de germinação, e aumento na velocidade de germinação quando utilizado o substrato rolo de papel. As temperaturas extremas não se mostraram favoráveis ao processo de formação de plántulas. De acordo com os resultados obtidos recomenda-se a utilização de rolo de papel, à 20 °C e com data de avaliação da primeira contagem aos 6 dias após a semeadura para teste de germinação.
Spatiotemporal Clustering of Repeated Super-Resolution Localizations via Linear Assignment Problem
Authors: Schodt David J. , Lidke Keith A.
Published: October 2021

Many fluorescence super-resolution techniques, such as (d)STORM, PALM, and DNA-PAINT, generate datasets wherein multiple localizations across many camera frames may arise from a single blinking event of an emitter. These repeated localizations not only hinder interpretation and analysis of such datasets, but also represent an incomplete use of the fluorescence photons. Such localizations are typically combined into a single localization either by clustering with hard distance and time thresholds, or by classical hypothesis testing assuming Gaussian localization errors. In this work, we describe a method for clustering that accounts for localization precision, local emitter density estimates, and a kinetic model for blinking which is used to optimize connections within a group of spatiotemporally colocated localizations.
Cyanophycin Modifications—Widening the Application Potential
Authors: Kwiatos Natalia , Steinbüchel Alexander
Published: October 2021

A circular bioeconomy approach is essential to slowing down the fearsome ongoing climate change. Replacing polymers derived from fossil fuels with biodegradable biobased polymers is one crucial part of this strategy. Cyanophycin is a polymer consisting of amino acids produced by cyanobacteria with many potential applications. It consists mainly of aspartic acid and arginine, however, its composition may be changed at the production stage depending on the conditions of the polymerization reaction, as well as the characteristics of the enzyme cyanophycin synthetase, which is the key enzyme of catalysis. Cyanophycin synthetases from many sources were expressed heterologously in bacteria, yeast and plants aiming at high yields of the polymer or at introducing different amino acids into the structure. Furthermore, cyanophycin can be modified at the post-production level by chemical and enzymatic methods. In addition, cyanophycin can be combined with other compounds to yield hybrid materials. Although cyanophycin is an attractive polymer for industry, its usage as a sole material remains so far limited. Finding new variants of cyanophycin may bring this polymer closer to real-world applications. This short review summarizes all modifications of cyanophycin and its variants that have been reported within the literature until now, additionally addressing their potential applications.
Genome Instability and Long Noncoding RNA Reveal Biomarkers for Immunotherapy and Prognosis and Novel Competing Endogenous RNA Mechanism in Colon Adenocarcinoma
Authors: Ren Ziyuan , Wang Zhonglin , Gu Donghong , Ma Hanchen , Zhu Yan , Cai Menghua , Zhang Jianmin
Published: October 2021

Background: Long noncoding RNAs (lncRNAs) crucially modulate DNA damage responses/repair in cancer cells. However, the underlying regulatory role of genome integrity and its clinical value in colon adenocarcinoma (COAD) remains unclear. This study links genome instability to lncRNA using computational biology techniques, in attempt to propose novel biomarkers of immunotherapy outcome, and investigated a potential competing endogenous RNA (ceRNA) as a molecular regulatory mechanism.

Methods: TCGA-COAD patients were divided into genome unstable (GU)-like and genome stable (GS)-like clusters via hierarchical clustering to predict immunotherapy outcomes. Multivariate Cox model was established to predict the overall survival rate in COAD patients. Additionally, SVM and LASSO algorithms were applied to obtain hub lncRNAs. A novel genome instability-related ceRNA network was predicted with the Starbase 2.0 database. To better understand how these genes fundamentally interact during tumor progression and development, the mutation analysis and single-gene analysis for each gene was performed.

Results: In contrast to those in the GS-like cluster, GU-like-cluster patients demonstrated a higher tumor mutational burden (TMB)/microsatellite instability (MSI), DNA polymerase epsilon (POLE) mutation rate, and immune checkpoint expression, all indicate a greater predictive power for response rate for immunotherapy. The novel prognostic signature demonstrated an outstanding predictive performance (AUC > 0.70). The genes in the genome insatiability-related ceRNA network (including four axes: AL161772.1-has-miR-671-5p (hsa-miR-181d-5p, has-miR-106a-5p)-NINL, AL161772.1-has-miR-106a-5p-TNFSF11, AC124067.4-hsa-miR-92b-3p (hsa-miR-589-5p)-PHYHIPL, and BOLA3-AS1-has-miR-130b-3p-SALL4) were identified as critical regulators of tumor microenvironment infiltration, cancer stemness, and drug resistance. qPCR was performed to validate the expression patterns of these genes. Furthermore, the MSI-high proportion was greater in patients with mutated type than in those with the wild type according to all four target genes, indicating that these four genes modulate genomic integrity and could serve as novel immunotherapy biomarkers.

Conclusion: We demonstrated that genome instability-related lncRNA is a novel biomarker for immunotherapy outcomes and prognosis. A novel ceRNA network that modulates genomic integrity, including four lncRNA-miRNA-mRNA axes, was proposed.
New Polyprenylated Acylphloroglucinol Derivatives and Xanthones From Hypericum wilsonii
Authors: Hao Ji , Zhou Tongxi , Ma Yuanren , Deng Jingtong , Cheng Haitao , Wang Qiang , Lin Qinxiong , Yang Xinzhou , Choi Hoyoung
Published: October 2021

Four new polyprenylated acylphloroglucinol derivatives, hyperwilone A-D (1–4), and two new xanthones, wilsonxanthone A (5) and wilsonxanthone B (6), together with eight known compounds were isolated from the aerial parts of Hypericum wilsonii. Their structures were expounded by comprehensive analysis of the 1D and 2D NMR spectra and HRESIMS. The relative configurations and absolute configurations of 1-6 were determined by NMR calculations and comparing their experimental and computed ECD data. All compounds were evaluated for GLUT4 translocation effects in L6 myotubes. Compound 5 showed the strongest GLUT4 translocation effects with 2.57 folds at a concentration of 30 μg/ml.
Novel Hydroxytyrosol-Donepezil Hybrids as Potential Antioxidant and Neuroprotective Agents
Authors: Costanzo Paola , Oliverio Manuela , Maiuolo Jessica , Bonacci Sonia , De Luca Giuseppina , Masullo Mariorosario , Arcone Rosaria , Procopio Antonio
Published: October 2021

It is well-accepted that the endogenous antioxidant protection system progressively decays in elderly people, and that the oxidative stress contributes to different neurodegenerative disorders such as Alzheimer’s Diseases (AD). The lower incidence of AD in countries which feature the Mediterranean Diet was associated to the high consumption of extra virgin olive oil and its polyphenolic fraction, in particular hydroxytyrosol. The protective role of these bio-phenols against oxidative stress, suggested that we combine their antioxidant/free radical scavenging activity with donepezil, an active ingredient which has just been approved for the treatment of AD. Different synthetic strategies were tested to conjugate the two different synthons in good yields. Additionally, a nitro-hydroxytyrosol derivative was synthesized to extend the application to other neurodegeneration inflammatory models. Then, their bioactivity was measured in different chemical and biological tests on a human neuroblastoma cell line (SHSY-5Y). Remarkable results on cell viability and the regulation of the redox state of cells were obtained. All hybrids showed negligible cell death under 1 μM and are stable and non toxic. Reactive oxygen species (ROS) measurements showed that the nitro-hybrid was the more effective one at reducing the ROS amount to physiological values. Then, in light of the bio-metal hypothesis of diverse neurodegenerative disorders, we tested these new compounds on the chelation properties of redox-active metals. The nitro-hybrid was able to chelate all of the tested metal cations, suggesting that we propose it as potential lead compound for a new class of neuroprotective antioxidant agents.
Hyper-Virulent Listeria monocytogenes Strains Associated With Respiratory Infections in Central Italy
Authors: Guidi Fabrizia , Chiaverini Alexandra , Repetto Antonella , Lorenzetti Cinzia , Centorotola Gabriella , Bazzucchi Viviana , Palombo Barbara , Gattuso Antonietta , Pomilio Francesco , Blasi Giuliana
Published: October 2021

Listeria monocytogenes (Lm) is a foodborne pathogen causing listeriosis. Invasive forms of the disease mainly manifest as septicaemia, meningitis and maternal-neonatal infections. Lm-associated respiratory infections are very rare and little known. We reported two Lm respiratory infection cases occurred in Central Italy during the summer of 2020, in the midst of the SARS-CoV2 pandemic. In addition to collect the epidemiological and clinical characteristics of the patients, we used Whole Genome Sequencing to study the genomes of the Lm isolates investigating their virulence and antimicrobial profiles and the presence of genetic mobile elements. Both the strains belonged to hypervirulent MLST clonal complexes (CC). In addition to the Listeria Pathogenicity Island 1 (LIPI-1), the CC1 strain also carried LIPI-3 and the CC4 both LIPI-3 and LIPI-4. Genetic determinants for antimicrobial and disinfectants resistance were found. The CC1 genome presented prophage sequences but they did not interrupt the comK gene, involved in the phagosomal escape of Lm. None of the strains carried plasmids. Lm is an important, although rare, opportunistic pathogen for respiratory tract and lung infections. To avoid dangerous diagnostic delays of these severe clinical forms, it is important to sensitize hospital laboratories to this rare manifestation of listeriosis considering Lm in the differential diagnosis of respiratory infections.