bluuebunny/crossref_metadata_2025 huggingface dataset:
Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain
Authors: Obernier Kirsten , Alvarez-Buylla Arturo
Published: February 2019

In the adult rodent brain, neural stem cells (NSCs) persist in the ventricular-subventricular zone (V-SVZ) and the subgranular zone (SGZ), which are specialized niches in which young neurons for the olfactory bulb (OB) and hippocampus, respectively, are generated. Recent studies have significantly modified earlier views on the mechanisms of NSC self-renewal and neurogenesis in the adult brain. Here, we discuss the molecular control, heterogeneity, regional specification and cell division modes of V-SVZ NSCs, and draw comparisons with NSCs in the SGZ. We highlight how V-SVZ NSCs are regulated by local signals from their immediate neighbors, as well as by neurotransmitters and factors that are secreted by distant neurons, the choroid plexus and vasculature. We also review recent advances in single cell RNA analyses that reveal the complexity of adult neurogenesis. These findings set the stage for a better understanding of adult neurogenesis, a process that one day may inspire new approaches to brain repair.
We develop social skills: parents of children with disabilities
Authors: Закрепина Алла , Zakrepina Alla
Published: February 2019

This book is written for parents whose children have limited health opportunities and therefore have difficulties with socialization. Here parents will find detailed descriptions of games aimed at the development of social skills of their children. Some of these games are possible in everyday situations, others require the organization of a special playing space. For each, a description of the possible reactions of children to the game actions and pedagogical techniques that allow to adapt the game situation to the needs of each child. The book will be useful not only for parents but also for specialists.
Right
Authors: Ефимова Ольга , Efimova Ol'ga , Ведышева Наталия , Vedysheva Nataliya , Питько Елена , Pitko Elena
Published: February 2019

The textbook covers the basics of the state and state structure, the basic concepts of law. The basic provisions of such branches of law as constitutional, civil, family, administrative, criminal law and other branches of law are determined, the elements of the relevant legal relations are shown. The presentation of the material is carried out in accordance with the principles of objectivity and specificity, generally recognized laws of formal and dialectical logic.
Meets the requirements of the Federal state educational standard of secondary vocational education and higher education of the last generation.
For students and students of law faculties of educational institutions of secondary professional and higher education, as well as studying or interested in the problems of state and law.
Tank device
Authors: Зайчиков Юрий , Zaychikov Yuriy
Published: February 2019

This manual is intended to assist teachers in preparing for classes, and students-in the independent study of the purpose, the General structure, operation and testing of devices and systems of electrical equipment and collective protection system of the tank, purpose, General device, operation and testing of weapons, special equipment of the tank, as well as in the study of the purpose and features of the General device BMP - 2 and BTR-80.
In detail, the manual contains sections: the General device of the electrical system of the tank, the system of electric start of the engine and power supply to consumers, consumers of electric energy, the system of collective protection against weapons of mass destruction and fire equipment, machine gun PKT, anti-aircraft installation, tank gun, tank ammunition, automatic charging, tank aiming devices, observation and orientation, fire control system of the tank, equipment to overcome water obstacles, equipment for self-digging, the General device BMP-2, BTR-80, features of the device of other samples of BTW.
NEWS ANALYSIS
Authors: McAlees Melissa
Published: February 2019

The charity Age UK has urged the Government to facilitate recruitment of care workers from the EU. With shortages in social care already present, the sector cannot afford to lose EU staff.
Urinary incontinence: promoting independence and dignity
Authors: Yates Ann
Published: February 2019

Urinary incontinence is prevalent in the older population, but it is not an inevitable consequence of growing older. Ann Yates addresses the root causes and sets out how to promote or return continence, rather than manage incontinence
Organising photography courses for residents and staff
Authors: Ashurst Adrian
Published: February 2019

Learning new things is a joy for people of any age, and it can highly increase the quality of life of older people living in care homes. Adrian Ashurst describes how to organise photography courses that can be jointly attended by residents and staff
A primary inferior lumbar hernia misdiagnosed as a lipoma
Authors: Kadler B , Shetye A , Patten DK , Al-Nowfal A
Published: February 2019

Lumbar hernias can be superior (Grynfelt) and inferior (Petit). Inferior lumbar hernias are extremely rare and, therefore, are associated with diagnostic difficulty. We present a case of a primary spontaneous inferior lumbar hernia in a 79-year-old woman that was initially diagnosed as a large lipoma on ultrasound. The first operation was abandoned and an open mesh repair was conducted.

Lumbar hernias can be primary acquired (55%), secondary acquired (25%) or congenital (20%). Cross-sectional imaging by CT or MRI appears to be the gold standard in diagnosis as ultrasound may lead to misdiagnosis. Strangulation, incarceration and obstruction are recognised complications, requiring prompt surgical intervention. There are currently no guidelines for surgical managements, although laparoscopic surgery may give the best results. In view of the scarcity of published cases, we aim to add to the literature to raise the index of suspicion and to promote prompt surgical management of lumbar hernias.
Quelles réflexions sur les retombées économiques du patrimoine : pour une valorisation des gravures rupestres d’Ait Ouaazik
Authors: Faouzi Dr. Mustapha
Published: February 2019

Les gravures rupestres d’Aït Ouaazik sont parmi les plus connus du Sud marocain. Elles se trouvent à 70km de route au nord de Zagora, région Draa Tafilalet (Maroc). Le village est situé dans une oasis dans le bassin de Maider, près de Tazzarine. Ces pétroglyphes dateraient du Néolithique. A cette époque la région Aït Ouaazik était une steppe.. Ces musées à ciel ouvert sont en grande partie méconnus, mais ceux dont le public a connaissance souffrent aujourd’hui de dégradations : climat et vandalisme. «Les aires rupestres marocaines sont d’accès libre et aucun droit de visite n’est acquitté par personne. Ce patrimoine aura des retombées économiques directes et indirectes s’il est valorisé. Et par conséquent, l’amélioration des conditions de vie de la population locale qui sera prise en compte dans l’exploitation et la valorisation du site. En effet, s’approprier le patrimoine par sauvegarde d’abord, la réhabilitation et également le plaidoyer pour son rayonnement. C’est dans ce sens que l’Agence nationale pour le développement des zones oasiennes et de l’arganier (ANDZOA), dans le cadre du projet d’adaptation aux changements climatiques (PACCZO) compte avec tous les acteurs locaux, à entamer des mesures pour réhabiliter ce site afin de drainer des ressources à cette localité en soutenant des initiatives locales au profit des jeunes et des femmes dans les secteurs de l’agriculture, le tourisme, la culture et l’artisanat.
Regenerasi Jamuju (Dacrycarpus imbricatus (Blume.) de Laub.) di Cagar Alam Gebugan, Kabupaten Semarang Jawa Tengah
Authors: Waskitaningtyas Evananda , Utami Sri , Wiryani Erry
Published: February 2019

Gebugan Nature Reserve is one of the protected forest that still has the natural habitat of Dacrycarpus imbricatus. D. imbricatus has the potential of producing wood that is widely used by the people while the exploitation of Jamuju causes this tree species difficult to find in their natural habitat. The aim of this research was to asses D. imbricatus regeneration. The method used for taking jamuju was systematic method. The number of plots used were 15 with 10 m x 10 m area for each plot. The number of individual jamuju at the tree level, pole level, sapling level and seedling level were counted at each plot. The result of this research showed the regeneration of jamuju in Gebugan Nature Reserve was poor, indicated by tree-level individual density (5 individuals/0.15 ha = 33.3 ind/ha), pole level (not found), sapling (4 individuals/0.15 ha = 26.6 ind/ha), and seedlings (21 individuals/0.15 ha = 140 ind/ha). The environmental factors of Jamuju were found to grow at the altitude of 1,050 m asl, temperature 26.7°C to 27°C, humidity 53% to 61%, soil pH 6.3 to 7.
Shallow water sponges that associated to mangrove ecosystem at Labuhan conservation area in Sepulu, Bangkalan, Madura, East Java Province
Authors: Setiawan Edwin , Muzaki Farid Kamal , Ashuri Nova Maulidina
Published: February 2019

Sponges (Porifera) are benthic sessile animals that have an important role in coastal ecosystems. Mangrove habitat is an example of a coastal ecosystem that can be inhabited by sponges. Research diversity on shallow water sponges in mangrove areas in Indonesia or even large scale such as the Indo-Pacific area are still relatively underestimated because of an extreme difference tidal factors. For this reason, we aimed to research a diversity of shallow water sponges in mangrove Indonesia, especially in  East Java Province to enrich and inform additional data on its biodiversity. Research on shallow water sponges in mangrove was conducted from June 2017 to January 2018 at two stations located on the coast of Labuhan Village, Sepulu District, Bangkalan Regency, Madura - East Java. Mangrove areas are consisted of Sonneratiaarea in the west (B) and Rhizophoramangroves in the east (R). There were six sponge genera identified, namely Spongia, Dysisdea, Lendelfedia, Dactylospongia, Cynachyrellaand one unidentified genus. Sonneratiamangrove was inhabited by of five genera sponges, whereas Rhizoporamangrove was inhabited only by one genus
Usytuowanie OLAF w systemie wielopoziomowego zarządzania Unii Europejskiej
Authors: Ruszkowski Janusz
Published: February 2019

Autor opracowania stawia sobie za cel zbadanie usytuowania OLAF-u w systemie wielopoziomowego zarządzania UE (Multi-level Governance - MLG) wraz z określonymi interinstytucjonalnymi zależnościami i konsekwencjami takiego usytuowania, przy założeniu, że OLAF nie jest klasyczną instytucją ponadnarodową. Skoro OLAF jako agent i supervisor posiada kompetencje kontrolne nad instytucjami ponadnarodowymi, w tym nad swoim mocodawcą, jakim jest ponadnarodowa Komisja Europejska, to mało prawdopodobne jest, aby był także instytucją ponadnarodową.W badaniach wykorzystano dwa narzędzia teoretyczno-metodologiczne: Principal/Agent Theory oraz Principal/Supervisor/Agent Theory.
Chinese Belt and Road Initiative – the perspective of the Federal Republic of Germany
Authors: Ciesielska-Klikowska Joanna
Published: February 2019

Chińska Republika Ludowa osiągnęła pozycję jednego z głównych graczy na arenie międzynarodowej i odważnie realizuje politykę ekspansji zagranicznej. Jej podstawowym instrumentem jest inicjatywa Pasa i Szlaku (Belt and Road Initiative, BRI), która w ostatnich latach jest jednym z najważniejszych projektów chińskich władz, zakładającym zintensyfikowanie współpracy gospodarczej i wymianę kulturalną krajów wzdłuż Nowego Jedwabnego Szlaku. Niemcy, czołowe państwo UE i kluczowy partner Chin w Europie, są silnym zwolennikiem inicjatywy BRI. Ponieważ jednak koncepcja ta obejmuje państwa członkowskie Unii Europejskiej, wymaga również silnej reakcji ze strony Wspólnoty. I chociaż stosunki UE z ChRL leżą w interesie gospodarczym wszystkich jej państw członkowskich, w ostatnich latach nie były one wolne od komplikacji. Artykuł analizuje znaczenie społecznego postrzegania i postaw aktorów państwowych Republiki Federalnej Niemiec wobec projektu Pasa i Szlaku od 2013 r., stosując liberalne podejście wyjaśniające. Celem artykułu jest przeanalizowanie reakcji Niemiec na inicjatywę Nowego Jedwabnego Szlaku w dwóch różnych fazach: pierwszej (2013-2016) i drugiej fazie (2016-), w której wypracowano model współpracy i świadomość występujących konfliktów. Ponadto artykuł próbuje zidentyfikować problemy istniejące w stosunkach między Unią Europejską a Chi­nami, ze szczególnym naciskiem na stosunki między Chińską Republiką Ludową a Republiką Federalną Niemiec. Analizę kończą krótki wniosek teoretyczny oraz rekomendacje polityczne.
Statin use and histopathological change in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis
Authors: Rattanachaisit Pakkapon , Susantitaphong Paweena , Thanapirom Kessarin , Chaiteerakij Roongruedee , Komolmit Piyawat , Tangkijvanich Pisit , Treeprasertsuk Sombat
Published: February 2019

Background

Non-alcoholic fatty liver disease (NAFLD) is one of the major causes of chronic liver disease. The primary treatment of NAFLD by statins has not been clearly elucidated.

Objectives

To evaluate the effectiveness of statin use in patients with biopsy-proven NAFLD or non-alcoholic steatohepatitis on the change in liver histology.

Methods

We searched MEDLINE, Scopus, Google Scholar, and the Cochrane Central Register of Controlled Trials for clinical trials and observational studies investigating the effects of statins on histological change regardless of type or dosage from inception to December 2015. Random-effect model meta-analyses were used to compute changes in outcomes of interest. The study protocol was registered in advance with the International Prospective Register of Systematic Reviews (PROSPERO 2016 CRD42016033132).

Results

We identified 6 studies (111 patients), representing 5 cohort studies and 1 randomized controlled clinical trial. There was significant decrease in steatosis grading with a standardized mean difference of –2.580 (95% confidence interval [CI] –4.623 to –0.536; P = 0.013) and NAFLD activity score standardized mean difference of –1.488 (95% CI –2.506 to –0.471; P = 0.004). However, there was no significant change in fibrosis stage (0.156; 95% CI –0.553 to 0.865; P = 0.667).

Conclusions

Statin use can possibly reduce the extent of steatohepatitis but not the stage of fibrosis. Further randomized controlled studies to assess histological evidence with adequate sample size and duration are required in order to establish the role of statin as a primary treatment of NAFLD.
In vitro study of the anticancer activity of various doxorubicin-containing dispersions
Authors: Matvienko Tatiana , Sokolova Viktoriya , Prylutska Svitlana , Harahuts Yuliia , Kutsevol Nataliya , Kostjukov Viktor , Evstigneev Maxim , Prylutskyy Yuriy , Epple Matthias , Ritter Uwe
Published: February 2019

Introduction: The aim of this research was to study the impact of various doxorubicin (Dox)-containing nanofluids, e.g. singlewalled carbon nanotube (SWCNT)+Dox, graphene oxide (GO)+Dox and DextranPNIPAM (copolymer)+Dox mixtures on HeLa cells (human transformed cervix epithelial cells, as a model for cancer cells) depending on their concentration. Methods: Structural analysis of GO+Dox complex was accomplished using Hartree-Fock level of theory in 6-31G** basis set in Gaussian. Dynamic light scattering (DLS), zeta-potential, scanning electron microscopy and confocal laser scanning microscopy were used. The cell viability was analyzed by the MTT assay. Results: The viability of HeLa cells was studied with the MTT assay after the incubation with various Dox-containing dispersions depending on their concentration. The size of the particles was determined by DLS. The morphology of the nanoparticles (NPs) was studied by scanning electron microscopy and their uptake into cells was visualized by confocal laser scanning microscopy. It was found that the Dextran-PNIPAM+Dox nanofluid in contrast to Dox alone showed higher toxicity towards HeLa cells up to 80% after 24 hours of incubation, whereas the SWCNT+Dox and GO+Dox nanofluids at the same concentrations protected cells from Dox. Conclusion: The importance of Dextran-PNIPAM copolymer as a universal platform for drug delivery was established, and the huge potential of Dextran-PNIPAM+Dox NPs as novel anticancer agents was noted. Based on the in vitro study of the SWCNT+Dox and GO+Dox nanofluids, it was concluded that SWCNT and GO NPs can be effective cytoprotectors against the highly toxic drugs.
Aid Effectiveness in the Sustainable Development Goals Era Comment on ""It’s About the Idea Hitting the Bull’s Eye": How Aid Effectiveness Can Catalyse the Scale-up of Health Innovations"
Authors: Ogbuoji Osondu , Yamey Gavin
Published: February 2019

Over just a six-year period from 2005-2011, five aid effectiveness initiatives were launched: the Paris Declaration on Aid Effectiveness (2005), the International Health Partnership plus (2007), the Accra Agenda for Action (2008), the Busan Partnership for Effective Cooperation (2011), and the Global Partnership for Effective Development Cooperation (GPEDC) (2011). More recently, in 2015, the Addis Ababa Action Agenda (AAAA) was signed at the third international conference on financing for development and the Universal Health Coverage (UHC) 2030 Global Compact was signed in 2017. Both documents espouse principles of aid effectiveness and would most likely guide financing decisions in the Sustainable Development Goals (SDG) era. This is therefore a good moment to assess whether the aid effectiveness agenda made a difference in development and its relevance in the SDG era.
Flexibilización probatoria y equidad: Propuestas para la justicia del posconflicto
Authors: Sánchez Gutiérrez Juan Felipe , Córdoba Hernández Michael Julián , Serrano Manrique Hannier Santiago , Castro Bermúdez Adriana Carolina
Published: February 2019

The Inter-American Court of Human Rights, following guidelines of ius cogens and soft law in relation with the victim’s rights, has created rules of probative flexibilization to guarantee the effective jurisdictional tutelage to the victims of serious human rights violations. Thanks to this scenario, in Colombia, due of the legal-procedural design that has been created in virtue of the armed conflict, practices used in the ISHR have been insufficiently adopted in terms of probative flexibilization and the use of equity. The tools provided conforming to IHRL and IHL, when it will be adopted in a more comprehensive way, will provide more guarantees for victims, and will be a great practical and hermeneutical assistance to the damage judge to base their decisions for integral reparation incidents and direct reparation processes when they were related with serious violations of human rights.
Positive solutions of higher order fractional integral boundary value problem with a parameter
Authors: Hao Xinan , Zhang Luyao , Liu Lishan
Published: February 2019

In this paper, we study a higher-order fractional differential equation with integral boundary conditions and a parameter. Under different conditions of nonlinearity, existence and nonexistence results for positive solutions are derived in terms of different intervals of parameter. Our approach relies on the Guo–Krasnoselskii fixed point theorem on cones.
Stability analysis of fractional differential equations with unknown parameters
Authors: Koksal Mehmet Emir Emir
Published: February 2019

In this paper, the stability of fractional differential equations (FDEs) with unknown parameters is studied. Using the graphical based D-decomposition method, the parametric stability analysis of FDEs is investigated without complicated mathematical analysis. To achieve this, stability boundaries are obtained firstly by a conformal mapping from s-plane to parameter space composed by unknown parameters of FDEs, and then the stability region set depending on the unknown parameters is found. The applicability of the presented method is shown considering some benchmark equations, which are often used to verify the results of a new method. Simulation examples show that the method is simple and give reliable stability results.
On Fučík type spectrum for problem with integral nonlocal boundary condition
Authors: Sergejeva Natalija , Pečiulytė Sigita
Published: February 2019

The Fučík equation x' '= -μ x+λ x- with two types of nonlocal boundary value conditions are considered. The Fučík type spectrum for both problems are constructed. The visualization of the spectrum for some values of parameter γ is provided.
Ki-67 status in patients with primary breast cancer and its relationship with other prognostic factors
Authors: Kermani Touraj Asvadi , Kermani Iraj Asvadi , Faham Zhaleh , Dolatkhah Roya
Published: February 2019

Introduction: Breast cancer (BC) is the most common cancer in women and is the second most common cause of fatality in patients with cancer in the world. Cell proliferation plays an important role in the clinical behavior of invasive BC. We aimed to assess the status of Ki-67 in patients with primary breast cancer and evaluate the association of this tumor marker with other clinico-pathologic and prognostic factors.

Methods: The current study recruited 220 patients with primary BC admitted to the oncology clinic of the Tabriz University of Medical Sciences. We evaluated Ki-67 IHC slides and reported the Ki-67 status and its relationship with other prognostic factors in breast cancer patients. Among 220 patients, 63.3% developed grade 2 tumors, and 63.8% were younger than 50-year-olds. 117 cases (53%) were Ki-67 positive with more than 1% tumor nuclei stained, and 53 cases (24%) had tumors with more than 15% of Ki-67 expression.

Results: There was no correlation between Ki-67 and patient's age (Spearman rho = 0.375, tau Kendall = 0.374), tumor size (Spearman rho = 0.558, tau Kendall = 0.548) and grade (Spearman rho = 0.570, tau Kendall = 0.568), however, there was a marginally significant relationship between lymph node status and Ki-67 expression (Spearman rho = 0.077, tau Kendall = 0.079). Based on the Mann -Whitney test, there was a significant correlation between the expression of estrogen receptor (ER) and progesterone receptor (PR) with Ki-67.

Conclusion: A reliable estimation of different prognostic factors in BC patients is required for the selection of an optimal therapeutic strategy. The attention has been focused on the markers of tumor biology.
Desarrollo de vectores génicos basados en polímeros sintéticos: PEI y PDMAEMA
Authors: Díaz-Ariza Ivonne Lorena , Sierra César Augusto , Pérez-Pérez León Darío
Published: February 2019

En años recientes hubo un auge del uso de terapias génicas para el tratamiento de enfermedades de gran incidencia, como el cáncer. Generalmente, estas se basan en la liberación de material genético como plásmidos, en el núcleo celular, con lo cual se corrige una función o se induce la producción de proteínas deficientes a nivel fisiológico. Para llevar a cabo la terapia génica se requiere de vectores capaces de encapsular el material genético y garantizar su entrega en el núcleo celular. Los polímeros catiónicos sintéticos han llamado la atención como vectores, debido a su capacidad de condensar ácidos nucleicos para formar partículas que los protegen de la degradación enzimática y facilitan su captación celular.La polietilenimina y el polimetacrilato de N, N-dimetilaminoetilo son los polímeros catiónicos más eficaces para la administración génica. Sin embargo, estos requieren modificaciones químicas específicas para eliminar o disminuir algunas limitaciones tales como su alta citotoxicidad y baja biodegradabilidad. En este artículo se analizan algunas de estas modificaciones, enfocándose en avances recientes en el desarrollo de copolímeros anfifílicos como precursores de nanopartículas usadas como vectores génicos.
Validación de una metodología analítica por HPLC-DAD para la cuantificación de ácido benzoico complejado, en un ensayo de permeación transdérmica in vitro empleando piel de cerdo
Authors: Martínez Laura A. , Martínez Jorge A. , Baena Yolima
Published: February 2019

En el presente estudio se realizó la validación de una metodología analítica por cromatografía líquida de alta eficiencia con detector de arreglo de diodos (HPLC-DAD) para la cuantificación del ácido benzoico en complejos polielectrolíticos, obtenidos con Eudragit® E100. Para ello se evaluaron las características de desempeño determinando que la metodología es selectiva; lineal en el rango de concentraciones de 2 a 10 μg/mL; precisa con un RSD inferior a un 2%; exacta con un porcentaje de recuperación de un 98,7% y se establecieron límites de cuantificación (LOQ) de 0,72 y de 1,56 μg/mL para el sistema y método respectivamente. De acuerdo a estos resultados, la metodología analítica es adecuada para evaluar la permeación in vitro, del ácido benzoico incluido en los complejos polielectrolíticos a través de piel porcina, empleando celdas de Franz.
A descrição matemática do desempenho do novo derivado acridínico na detecção eletroanalítica do conteúdo total do ácido gálico em alfarroba
Authors: Tkach Volodymyr , Kushnir Marta V. , Ivanushko Yana G. , De Oliveira Sílvio C. , Zavhorodnii Mykhailo P. , Brazhko Oleksandr A. , Luganska Olga V. , Ahafonova Oleksandra V. , Yagodynets´ Petró I.
Published: February 2019

A possibilidade do uso de um novo derivado de acridina, munido de um grupo doador de elétrons, como modificador de elétrons para a detecção do conteúdo total do ácido gálico em goma de alfarroba tem sido avaliada mediante uma análise teórica. O modelo matemático correspondente foi analisado mediante a teoria de estabilidade linear e análise de bifurcações. Foi mostrado que o derivado fosfazoico da acridina pode servir de modificador eficiente para a detecção eletroanalítica do conteúdo total do ácido gálico em alfarroba. As causas dos comportamentos oscilatório e monotônico também foram detectadas.
Pinge Development Strategyas Turism Village in Baru Village, Kecamatan Marga,Tabanan Bali District
Authors: IGN Alit Wiswasta, Utari Vipritanti I Nyoman Purnata, I Wayan Gde Wiryawan,
Published: February 2019

The development of tourist villages will provide many benefits for both tourism and the people and culture of Bali. This research was conducted in Pinge, Pinge, which is one of the official offices in Baru Village, Marga Subdistrict, Tabanan Regency. The purpose of this study was to find the right strategy to develop Pinge as a Tourism Village. Data collection was carried out by observation, interviews, FGD, questionnaire techniques, documentation techniques. The researcher used a sampling technique with a sampling technique that was purposive sampling. The type of research used in this study is qualitative research (descriptive), the data analysis techniques used are SWOT and AHP (Analytical Hierarchy Process) analysis. In accordance with the results of internal and external matrix analysis (IFE and EFE), the position of internal environmental factors in developing the Pinge Tourism Village is in a STRONG position with a score of 3,086, while the position of external environmental factors in the position is 2,955. priority strategies that can be carried out by Pinge Village in the development of Pinge Village as a Tourism Village are the Environmental Management and Zone Management Strategy with an average value of 0.135 or 13.5%.
Investigation of the modulatory role of Bulgarian Mentha Piperita L. oil against radiation-induced oxidative disorders and antioxidant status In Vitro
Authors: Karamalakova Y.
Published: February 2019

This investigation report on the free radical-scavenging and radio-modulatory properties of Bulgarian M. piperita L. oil. The chemically pure oil (97 %) was tested alone and after expositer to ultraviolet radiation (290-320 nm) and gamma radiation at doses of 5, 10, 20 and 30 Gy. The in vitro antioxidant status studied by different spectrophotometrically methods of M. piperita alone was found to be lower compared to UVB and 10 Gy radiated oil. By direct EPR spectroscopy, single almost symmetrical EPR signals were registered in oil alone (g= 2.00492 ± 0.0003), UVB (g= 2.00586 ± 0.0002) and 10 Gy irradiated (g= 2.0019 ± 0.0002) samples. Antioxidant activity and radical scavenging capacity of M. piperita oil alone and after radiation was also evaluated by the DPPH test. The intensities of the EPR signals of M. piperita oil alone, and irradiated samples demonstrated the possible formation of stable radical structures. The EPR spectra considerably higher after radiation, and excellent DPPH scavenging capacity exhibited by M. piperita indicate good antioxidant potential, radio-modulatory activity and prevent effectively radiation–induced oxidative disorders.
Beneficial impact of human placenta extracts on erythrocyte membrane thermostability
Authors: Nardid O. , Repina S. , Bobrova E. , Govorova Yu. , Narozhnyi S. , Rozanova E.
Published: February 2019

PURPOSE: To study the influence of human placenta extract (HPE) and its individual fractions on the thermal stability of human erythrocyte membrane. METHODS: HPE fractions were isolated by gel chromatography. Thermal hemolysis of erythrocytes, exposed to 55°C was measured spectrophotometrically. Cytosol microvscosity and barrier function of erythrocyte membranes at hyperthermia were investigated by EPR spin probe TEMPON. Thermal denaturation of erythrocyte membrane proteins were studied by differential scanning calorimetry. RESULTS: Pre-treatment of erythrocytes with HPE or its fractions inhibited thermal hemolysis. Low-molecular fractions (below 4 kDa and 12-20 kDa) were the most effective in thermal hemolysis inhibition ((31.7±3.3) % and (31.5±3.2) %, respectively). The latter fractions markedly reduced the hyperthermia (55°C)-induced permeability of erythrocytes for ferricyanide ions and inhibited the thermo-induced structural transitions in erythrocyte membrane between 40 and 50°C, which are associated with cytoskeletal proteins. HPE fractions reversibly increased the denaturation temperatures of erythrocyte membrane proteins, except that of spectrin, and enlarged the enthalpy of denaturation of all membrane proteins. CONCLUSIONS: HPE and its individual fractions increased the thermal stability of erythrocyte membranes and erythrocytes. This effect was attributed to the reversible binding of some low molecular ingredient of HPE to the integral proteins and consequent stabilization of their interaction with under-membrane cytoskeleton.
Algoritm for diagnostics of appendicitis in childhood and SIRS
Authors: Dimcheva Y. , Kalinova Kr. , Georgiev K.
Published: February 2019

The specific purpose of this study was to describe and characterize the systemic inflammatory response to appendicitis in childhood. The clinical symptoms of SIRS are present in a large proportion of patients . A study of high-risk patients showed that over a given period of time, 44-68% of the patients met the criteria for this condition, while at the same time they had proven infection up to 50%.The incidence of SIRS is even higher in the post-operative period and in trauma regardless of the presence or absence of infection. On the other hand, between 10% and 43% of patients with proven sepsis do not meet the SIRS criteria.The inclusion of a number of biological markers (C-reactive protein, procalcitonin, cytokines) aims to help differentiate SIRS with infectious and noninfectious etiology. Sixty six patients were studied, divided into four groups from onset of symptoms to diagnosis. The primary outcome measure was to determine the systemic inflammatory response to appendicitis according to the established groups of time intervals. The secondary outcome measure was the analysis of C-reactive protein for the same purpose. The variables of the systemic inflammatory response, according to diagnostic intervals, showed non-significant differences in white blood cell count. The temperature rose constantly after 48 h, reaching its peak after 72 h (p = 0.001), and the respiratory rate rose after 72 h (p < 0.0001). After 73 h, most patients had three or four systemic inflammatory response criteria (p < 0.0001). C-reactive protein levels rose progressively, showing higher levels after 48 h (p = 0.005). The inflammatory response to appendicitis is progressive, being more marked along the timeline from onset of symptoms to diagnosis.
Key words: appendicitis, diagnostic SIRS, children, algoritm.
Application of nanofilters for ventilation
Authors: Rubina Aleš , Rubinová Olga , Blasinski Petr
Published: February 2019

Nanotechnology is a perspective manufacturing technology, and in the technical fields, it deals with the production, development and utilization of technologies and materials with dimensions in nanometre sizes (1–100 nm). Nanofilters used in the article for filtration purposes consist from a nanolayer which is applied to a coarse textile backing layer, and they are inserted into the frames as conventional textile filters. The most commonly used materials are PP and PE polymers, as well as carbon, glass and metal filters. With the fabrication of nanotechnology-based filter, it is very important to choose materials, polymers with specific properties, which can be used for filtration function of the product itself. The results given in the main article compare the nanofilters with the main representatives of existing filter products currently available on the market. There is a problem with high pressure loss of the nanomaterial, and when we compare them with traditional filters, it is difficult to use them in technical practice, even if there exists the possibility for us to define the material and the thickness of the layer which are adapted to the application-specific application conditions.
Component Analysis of Purification System of RSG-GAS
Authors: Susmikanti Mike , Hartini Entin , Saepudin Aep , Sulistyo Jos Budi
Published: February 2019

COMPONENT ANALYSIS OF PURIFICATION SYSTEM OF RSG-GAS. Component reliability analysis is required in the aging management of RSG-GAS that has reached an age of 30 years. One of the required analyses is the assessment of the distribution of repair data and the estimation of related parameters. The Primary Purification System (KBE01) and the Purification and Warm Water Layer System (KBE02) are important components of RSG-GAS. By knowing the repair data distribution, the parameters of the most frequently occurring component repair and the average of the repair period can be estimated, so that the required provision of spare parts for the smooth operation of the reactor can be predicted. The purpose of this study is to analyze the components of the KBE01 and KBE02 systems through the data distribution approach using the matching test method. With the matching test, the form of data distribution can be determined, so the parameter of the average component repair period that can be used as a comparison of the maintenance period of the components can be estimated. The repair times of KBE01 and KBE02 in RSG-GAS on Core 52 through Core 88 (2006-2015) were analyzed using goodness-of-fit test. The repair times of AA068 and AP001 KBE01 follow the exponential distribution with average repair times of 631.6 and 451.2 days, respectively. The repair times of WWL and AA002 KBE02 followed an exponential distribution with average repair times of 239.5 days and 888.0 days.
Study of Dispersion Hazard Potential of The LPG Stations Around the RDE Site in Rainy and Dry Season
Authors: Alimah Siti , Mellawati June
Published: February 2019

STUDY OF DISPERSION HAZARD POTENTIAL OF THE LPG STATIONS AROUND THE RDE SITE IN RAINY AND DRY SEASON. There are two LPG station (SPPBE) which are the depot of filling, storage and distribution of  Liquid Petroleum Gas (LPG) namely PT. BM and PT. ISR which the distance each are 2,995 and 4,141 km from Experimental Power Reactor (RDE) site with capacity 15 and 30 tons. LPG station is a stationary source, which is one aspect of the external human induced events that need to be analyzed in the preparation of site evaluation reports to obtain site permits. Hazard potential that may occur from the depot LPG are fire, explosion and dispersion of hazardous and toxic gas. The release of LPG due to valve leakage which is then dispersed at a certain dose has potentially harmful to health, even death to the population around  the RDE site. The purpose of the study was to know the effect of seasons (rainy and dry) to the potential hazard of LPG dispersion from LPG truck tank valve to the around RDE site. The method of study are collection the atmospheric data such as wind direction and speed, temperature and humidity, collection the station LPG characteristic, such as mass of gas, diameter and length of tank, and valve diameter, etc. The atmospheric data was obtained from Pondok Betung Climatology Station, in dry, transition, and rainy seasons, furthermore data was analyzed using ALOHA software version 5.4.5. The results show dispersion from LPG release due to valve  leakage from PT. BM and PT. ISR around the RDE site, in the dry season (April), the transition (January and July) as well as the rainy season (October) does not hazardous to the RDE site. Maximum threat zone occurs in dry season at April (wind speed 1.54 m/s), which reaches radius 179 m with airborne LPG concentration 5500 ppm, radius 111 m with concentration 17000 ppm and radius 71 m with concentration 53000 ppm.
Plug & Produce auf dem Sprung in den Markt
Authors: Bernshausen Jens , Haller Axel , Bloch Henry , Hoernicke Mario , Hensel Stephan , Menschner Anna , Stutz Andreas , Maurmaier Mathias , Holm Thomas , Schäfer Christian , Urbas Leon , Christmann Ulrich , Fleischer-Trebes Christoph , Stenger Frank
Published: February 2019

Modulare Automatisierung wird als eine der Schlüsseltechnologien zur Erhöhung der Flexibilität von Produktionsanlagen angesehen. Zugleich kann durch eine durchgängige Modularisierung von Produktionsanlagen und die Verwendung von Standards der Engineeringaufwand erheblich reduziert werden. Um dieses Ziel zu erreichen, arbeiten Namur (Interessengemeinschaft Automatisierungstechnik der Prozessindustrie) und der ZVEI (Zentralverband Elektrotechnik- und Elektronikindustrie) seit 2015 gemeinsam an der Spezifikation einer funktionalen, herstellerunabhängigen Beschreibung von Prozessmodulfunktionen, die aus dem Automatisierungsengineering eines Moduls heraus gewonnen werden kann. Durch den Import eines Module Type Packages (MTP) in eine übergeordnete Automatisierungsebene können dort die Modulfunktionen automatisch bereitgestellt werden. Durch die Kooperation mit dem Fachausschuss 5.16 der VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik(GMA) sind Teile der gemeinsamen Spezifikationen in die Richtlinienreihe VDI/VDE/Namur 2658 überführt worden. Diese bilden nun die Grundlage zur Entwicklung entsprechender Werkzeuge auf Seiten der Automatisierungshersteller, die bereits in Pilotprojekten erprobt wurden. Der Artikel stellt den Fortschritt bei der Spezifikation und Standardisierung des MTP dar und zeigt Ergebnisse aus Pilotprojekten, die den Nutzen des MTP und die damit einhergehende praxistaugliche Realisierung von Plug & Produce-Konzepten nachweisen.
Manisa-Spil Dağı’ndaki biyolojik çeşitliliği korumanın ekonomik değerinin belirlenmesi
Authors: Başar Hadiye , YÜCEL Arzu
Published: February 2019

Biyolojik kaynaklar ve çeşitliliği, ekosistemlerin sağladığı hizmetlerin temelini oluşturan önemli kaynaklardan biri olarak değerlendirilmektedir. Orman kaynaklarının bu yönüyle toplumsal refaha katkısı doğal kaynaklar içinde önemli bir yere sahip olup bu katkının değerlendirilmesine yönelik teknikler ve çalışmalar önem kazanmaktadır. Bu araştırmada, Ege Bölgesi içinde sanayileşme ve kentleşmenin etkilerinin artmakta olduğu Manisa ilinde önem kazanan Spil Dağı çalışma alanı olarak belirlenmiştir. Spil Dağı’ndaki biyoçeşitliliğin sağladığı hizmetlerin devamlılığını ve çevresinde yaşayanlarca önemini ortaya koymak amaçlanmıştır. Manisa il merkezinde yaşayan ve Spil Dağı’nı ziyarete gelen 444 birey ile yüz yüze görüşme tekniğiyle anket yapılmış ve Spil Dağı biyoçeşitliliğinin korunmasının toplumsal refaha katkısını belirlemek amacıyla koşullu değerleme yöntemi kullanılmıştır. Çalışmanın bulguları ile Spil Dağı biyoçeşitliliğini korumanın yıllık değeri 5.220.000 TL olarak tahmin edilmiştir.
A clinical study of aetiology of acute intestinal obstruction
Authors: Nasiruddin Syed , Patil Sharangouda , Pinate Anil Reddy
Published: February 2019

Background: Acute intestinal obstruction is one of common abdominal emergency and is associated with significant morbidity and mortality especially if it progresses to bowel ischemia. The diagnosis and management of the patient with intestinal obstruction is one of the more challenging emergencies that a general surgeon can come across. Although the mortality due to acute intestinal obstruction is decreasing with better understanding of pathophysiology and improvement in diagnostic techniques, fluid and electrolyte correction, much potent anti-microbials but still mortality ranges from 10-15% and more so in developing countries.Methods: The study will be conducted in the department of general surgery with symptoms and signs of acute intestinal obstruction admitted in the surgical ward. Fifty cases of intestinal obstruction have been studied. Patients belonged to all the age groups except infants are included in present study. The criteria for selection of cases was based on clinical history, physical findings, radiological and haematological investigations. The study was divided into clinical study, investigations and treatment. The results are tabulated stressing on following points age, sex, symptoms examination findings, investigations, abnormalities, probable causative factors, operative findings and operative procedure adopted and complications if any.Results: The commonest cause of intestinal obstruction in the adults in this study series was postoperative adhesions (36%) followed by obstructed/strangulated hernia (26%). Malignancy of the large bowel was seen in 9 cases constituting 18% of cases where as incidence of Volvulus of bowel was 4% in this series. Although pulmonary tuberculosis is more prevalent in India due to advent in use of antitubercular drugs incidence of abdominal tuberculosis is becoming less. In present study incidence of ileocaecal tuberculosis was 10%. One case of mesenteric ischaemia was present in our study.Conclusions: Acute intestinal obstruction remains an important surgical emergency in the surgical field. Success in the treatment of acute intestinal obstruction depends largely upon its early diagnosis, skilful management and treating the pathological effects of the obstruction just as much as the cause itself.
Implementation of fiqh based on the maslahah in murabahah financing in sharia banking
Authors: Atsar Abdul , Izuddin Azid
Published: February 2019

The law of Muamalat gives the freedom to bind themselves to contracts and conduct transactions for mutual benefits and benefits. Islamic banking prepares various types of contracts in accordance with sharia provisions, one of the murabahah contracts. The formulation of the problem in this study is how is the application of fiqh maslahah in Islamic banking murabahah financing contracts? The method used in this study is a normative juridical method, which refers to the concept of law as a rule. In this research the author of the legal approach, analytical approach. The specification of this study is descriptive analytical research. The type of data used in this study are secondary data and primary data. Data collection begins with activities to identify and inventory data sources. Drawing conclusions is done using inductive methods. Murabahah is a sale and purchase agreement between a bank and a customer where the bank buys the goods needed and resells the customer with a basic cost plus profits agreed by both parties, there is no coercion from the parties in making murabahah agreements. In making and implementing murabahah financing contracts must pay attention to public interests not just the interests of the parties. According to Islamic law in making contracts based on sharia principles, must prioritize the benefit and refuse harm to achieve the goal of shara, namely to increase the benefit of the people by guaranteeing basic needs (dharuriyah) and fulfilling secondary needs, needs (hajjiiyah) and their complementary needs.
Sukuk model determinant as funding strategy of Islamic Bank in Indonesia
Authors: Hadi Ryandono Muhamad Nafik
Published: February 2019

The Sukuk issued by Islamic banks in Indonesia has high flexibility and is a unique strategy in funding but in its implementation still faces many determinants that need to be identified. This research uses a qualitative approach and the type of research is exploratory with case study method. The research finds seven determinants of sukuk as an alternative source of fundraising. In fact, these 7 determinants are obstacles to the issuance of sukuk, so that Islamic banks in the issuance of sukuk tend to choose to become Special Purpose Vehicle and or as a selling agent of sukuk. If it is related to a special project, the Islamic bank will develop public fund raising with mudharabah-muqayadah contract. The sukuk model that is suitable and sought by investors in Islamic banks is sukuk based on revenue sharing which is partnership contract. It is since partnership sukuk yield reflects business reality and economic cycle so that it is fair for the owner of fund and fund manager.
Peran sumber daya manusia (SDM) dalam perkembangan perbankan syariah: sebuah analisis kualitas dan kinerja pegawai
Authors: Sari Nilam , Amri Abrar
Published: February 2019

Human resources have a very important role in a company organization especially when compared to other resources. Employee performance is a very important thing in an effort to achieve change in order to achieve its goals. This study discusses the influence of the quality of human resources on the performance of sharia banking employees in Aceh and how efforts should be made in improving the quality of sharia banking human resources in Aceh. The research method used is a mixed method (Mixed Method). Based on test variables obtained by tcount of 3.859 while t table of 2.048 the results of this calculation indicate that tcount> t table with a significance level of 0.001 or probability above α = 5%. Thus the results of statistical calculations indicate that the variable quality of human resources has a significant influence on employee performance. Which means that the higher the quality of human resources, the higher the performance of employees in Islamic banking. Efforts to improve the quality of banking Human Resources can be done through: 1) Evaluation of a sustainable Islamic economic curriculum in higher education institutions. 2) Establish a faculty / Islamic economic study program in accordance with the needs of the Islamic banking market. 3) Higher Education collaborates with Bank Indonesia to carry out Islamic economic education and training for students and employees of Islamic banks. 5) Education and training on banking to improve the quality of human resources in sharia banking is a short-term effort that can be done now. While the efforts made in the long term are by organizing education that is synergized between the education provider (college) user (bank) and the person in charge of education (government).