bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of the Surface Wind Field Representation in the Operational Storm Surge Model of the National Hurricane Center
Authors: Mayo Talea , Lin Ning
Published: April 2019

The Sea, Lake, and Overland Surges from Hurricanes (SLOSH) model is the operational storm surge model of the National Hurricane Center (NHC). Previous studies have found that the SLOSH model estimates storm surges with an accuracy of ±20%. In this study, through hindcasts of historical storms, we assess the accuracy of the SLOSH model for four coastal regions in the Northeastern United States. We investigate the potential to improve this accuracy through modification of the wind field representation. We modify the surface background wind field, the parametric wind profile, and the maximum wind speed based on empirical, physical, and observational data. We find that on average the SLOSH model underestimates maximum storm surge heights by 22%. The modifications to the surface background wind field and the parametric wind profile have minor impacts; however, the effect of the modification to maximum wind speed is significant—it increases the variance in the SLOSH model estimates of maximum storm surges, but improves its accuracy overall. We recommend that observed values of maximum wind speed be used in SLOSH model simulations when possible.
Robust SERS Platforms Based on Annealed Gold Nanostructures Formed on Ultrafine Glass Substrates for Various (Bio)Applications
Authors: Zhou Lan , Poggesi Simone , Casari Bariani Giuliocesare , Mittapalli Rakesh , Adam Pierre-Michel , Manzano Marisa , Ionescu Rodica Elena
Published: April 2019

In this study, stable gold nanoparticles (AuNPs) are fabricated for the first time on commercial ultrafine glass coverslips coated with gold thin layers (2 nm, 4 nm, 6 nm, and 8 nm) at 25 °C and annealed at high temperatures (350 °C, 450 °C, and 550 °C) on a hot plate for different periods of time. Such gold nanostructured coverslips were systematically tested via surface enhanced Raman spectroscopy (SERS) to identify their spectral performances in the presence of different concentrations of a model molecule, namely 1,2-bis-(4-pyridyl)-ethene (BPE). By using these SERS platforms, it is possible to detect BPE traces (10−12 M) in aqueous solutions in 120 s. The stability of SERS spectra over five weeks of thiol-DNA probe (2 µL) deposited on gold nano-structured coverslip is also reported.
Integrative Analysis Reveals Subtype-Specific Regulatory Determinants in Triple Negative Breast Cancer
Authors: Huang Shujun , Xu Wayne , Hu Pingzhao , Lakowski Ted M.
Published: April 2019

Different breast cancer (BC) subtypes have unique gene expression patterns, but their regulatory mechanisms have yet to be fully elucidated. We hypothesized that the top upregulated (Yin) and downregulated (Yang) genes determine the fate of cancer cells. To reveal the regulatory determinants of these Yin and Yang genes in different BC subtypes, we developed a lasso regression model integrating DNA methylation (DM), copy number variation (CNV) and microRNA (miRNA) expression of 391 BC patients, coupled with miRNA–target interactions and transcription factor (TF) binding sites. A total of 25, 20, 15 and 24 key regulators were identified for luminal A, luminal B, Her2-enriched, and triple negative (TN) subtypes, respectively. Many of the 24 TN regulators were found to regulate the PPARA and FOXM1 pathways. The Yin Yang gene expression mean ratio (YMR) and combined risk score (CRS) signatures built with either the targets of or the TN regulators were associated with the BC patients’ survival. Previously, we identified FOXM1 and PPARA as the top Yin and Yang pathways in TN, respectively. These two pathways and their regulators could be further explored experimentally, which might help to identify potential therapeutic targets for TN.
Kinase Regulation of HOX Transcription Factors
Authors: Primon Monika , Hunter Keith D. , Pandha Hardev S. , Morgan Richard
Published: April 2019

The HOX genes are a group of homeodomain-containing transcription factors that play important regulatory roles in early development, including the establishment of cell and tissue identity. HOX expression is generally reduced in adult cells but is frequently re-established as an early event in tumour formation and supports an oncogenic phenotype. HOX transcription factors are also involved in cell cycle regulation and DNA repair, along with normal adult physiological process including stem cell renewal. There have been extensive studies on the mechanism by which HOX proteins regulate transcription, with particular emphasis on their interaction with cofactors such as Pre-B-cell Leukaemia Homeobox (PBX) and Myeloid Ecotropic Viral Integration Site 1 (MEIS). However, significantly less is known of how the activity of HOX proteins is regulated. There is growing evidence that phosphorylation may play an important role in this context, and in this review, we draw together a number of important studies published over the last 20 years, and discuss the relevance of phosphorylation in the regulation and function of HOX proteins in development, evolution, cell cycle regulation, and cancer.
A Case of Identity: HOX Genes in Normal and Cancer Stem Cells
Authors: Smith Jessica , Zyoud Ahmad , Allegrucci Cinzia
Published: April 2019

Stem cells are undifferentiated cells that have the unique ability to self-renew and differentiate into many different cell types. Their function is controlled by core gene networks whose misregulation can result in aberrant stem cell function and defects of regeneration or neoplasia. HOX genes are master regulators of cell identity and cell fate during embryonic development. They play a crucial role in embryonic stem cell differentiation into specific lineages and their expression is maintained in adult stem cells along differentiation hierarchies. Aberrant HOX gene expression is found in several cancers where they can function as either oncogenes by sustaining cell proliferation or tumor-suppressor genes by controlling cell differentiation. Emerging evidence shows that abnormal expression of HOX genes is involved in the transformation of adult stem cells into cancer stem cells. Cancer stem cells have been identified in most malignancies and proved to be responsible for cancer initiation, recurrence, and metastasis. In this review, we consider the role of HOX genes in normal and cancer stem cells and discuss how the modulation of HOX gene function could lead to the development of novel therapeutic strategies that target cancer stem cells to halt tumor initiation, progression, and resistance to treatment.
Facet-Dependent Interfacial Charge Transfer in TiO2/Nitrogen-Doped Graphene Quantum Dots Heterojunctions for Visible-Light Driven Photocatalysis
Authors: Ou Nan-Quan , Li Hui-Jun , Lyu Bo-Wen , Gui Bo-Jie , Sun Xiong , Qian Dong-Jin , Jia Yanlin , Wang Xianying , Yang Junhe
Published: April 2019

Interfacial charge transfer is crucial in the efficient conversion of solar energy into fuels and electricity. In this paper, heterojunction composites were fabricated, comprised of anatase TiO2 with different percentages of exposed {101} and {001} facets and nitrogen-doped quantum dots (NGQDs) to enhance the transfer efficiency of photo-excited charge carriers. The photocatalytic performances of all samples were evaluated for RhB degradation under visible light irradiation, and the hybrid containing TiO2 with 56% {001} facets demonstrated the best photocatalytic activity. The excellent photoactivity of TiO2/NGQDs was owed to the synergistic effects of the following factors: (i) The unique chemical features of NGQDs endowed NGQDs with high electronic conductivities and provided its direct contact with the TiO2 surface via forming Ti–O–C chemical bonds. (ii) The co-exposed {101} and {001} facets were beneficial for the separation and transfer of charge carriers in anatase TiO2. (iii) The donor-acceptor interaction between NGQDs and electron-rich {101} facets of TiO2 could remarkably enhance the photocurrent, thus hindering the charge carriers recombination rate. Extensive characterization of their physiochemical properties further showed the synergistic effect of facet-manipulated electron-hole separation in TiO2 and donor-acceptor interaction in graphene quantum dots (GQDs)/TiO2 on photocatalytic activity.
A Review on Thermal Conversion of Plant Oil (Edible and Inedible) into Green Fuel Using Carbon-Based Nanocatalyst
Authors: Abdulkareem-Alsultan G. , Asikin-Mijan N. , Lee H. V. , Rashid Umer , Islam Aminul , Taufiq-Yap Y. H.
Published: April 2019

Renewable diesels (e.g., biodiesel and green diesel) have emerged as a sustainable alternative to petrodiesel as a means of meeting the growing demand for fuel without damaging the environment. Although renewable diesels are composed of different chemical compositions to petrodiesel, they provide similar fuel characteristics as petrodiesel. The present articles focused on various type of green diesel, where the properties and its performance are discussed in detail. Green diesels offer multiple benefits over petrodiesel in terms of biodegradability, environmental protection and low toxicity. Additional, this paper described various types of process for green diesels production such as deoxygenation, hydrodeoxygenation, and pyrolysis. Among the synthesis process, the most effective and economical route to produce green diesel is through deoxygenation (DO). This study also emphasizes the use of a carbon-based catalyst for the DO reaction. The carbon-based catalyst renders several advantageous in term of highly resistance toward coke formation, greater catalyst stability, and product selectively, where the DO process occur via carbon–oxygen cleavage of fatty acid chain yielding diesel-like hydrocarbons. Due to this reason, various methods for synthesizing effective carbon-based catalysts for the DO reaction are further reviewed. Coke affinity over carbon-base catalyst during DO process is further discussed in the present study. Besides, DO operating condition toward optimum yield of hydrocarbons and recent progress in DO of realistic oil for production of diesel-like hydrocarbons are also discussed herein.
Dermatopontin in Skeletal Muscle Extracellular Matrix Regulates Myogenesis
Authors: Kim Taeyeon , Ahmad Khurshid , Shaikh Sibhghatulla , Jan Arif Tasleem , Seo Myung-Gi , Lee Eun Ju , Choi Inho
Published: April 2019

Dermatopontin (DPT) is an extensively distributed non-collagenous component of the extracellular matrix predominantly found in the dermis of the skin, and consequently expressed in several tissues. In this study, we explored the role of DPT in myogenesis and perceived that it enhances the cell adhesion, reduces the cell proliferation and promotes the myoblast differentiation in C2C12 cells. Our results reveal an inhibitory effect with fibronectin (FN) in myoblast differentiation. We also observed that DPT and fibromodulin (FMOD) regulate positively to each other and promote myogenic differentiation. We further predicted the 3D structure of DPT, which is as yet unknown, and validated it using state-of-the-art in silico tools. Furthermore, we explored the in-silico protein-protein interaction between DPT-FMOD, DPT-FN, and FMOD-FN, and perceived that the interaction between FMOD-FN is more robust than DPT-FMOD and DPT-FN. Taken together, our findings have determined the role of DPT at different stages of the myogenic process.
Saturated Fatty Acid-Enriched Diet-Impaired Mitochondrial Bioenergetics in Liver From Undernourished Rats During Critical Periods of Development
Authors: Simões-Alves Aiany C. , Costa-Silva Joao H. , Barros-Junior Idelfonso B. , da Silva Filho Reginaldo C. , Vasconcelos Diogo A. A. , Vidal Hubert , Morio Béatrice , Fernandes Mariana P.
Published: April 2019

The nutritional transition that the western population has undergone is increasingly associated with chronic metabolic diseases. In this work, we evaluated a diet rich in saturated fatty acids (hyperlipidic, HL) after weaning of the offspring rats submitted to maternal protein restriction on the hepatic mitochondrial bioenergetics. Wistar rats were mated and during gestation and lactation, mothers received control diets (NP, normal protein content 17%) or low protein (LP, 8% protein). After weaning, rats received either NL (normolipidic) or HL (+59% SFA) diets up to 90 days of life. It was verified that all respiratory states of hepatic mitochondria showed a reduction in the LP group submitted to the post-weaning HL diet. This group also presented greater mitochondrial swelling compared to controls, potentiated after Ca2+ addition and prevented in the presence of EGTA (calcium chelator) and cyclosporin A (mitochondrial permeability transition pore inhibitor). There was also an increase in liver protein oxidation and lipid peroxidation and reduction in catalase and glutathione peroxidase activities in the LP group fed HL diet after weaning. Our data suggest that adult rats subjected to maternal protein restriction were more susceptible to hepatic mitochondrial damage caused by a diet rich in saturated fatty acids post-weaning.
Diverse Role of SNARE Protein Sec22 in Vesicle Trafficking, Membrane Fusion, and Autophagy
Authors: Adnan Muhammad , Islam Waqar , Zhang Jing , Zheng Wenhui , Lu Guo-Dong
Published: April 2019

Protein synthesis begins at free ribosomes or ribosomes attached with the endoplasmic reticulum (ER). Newly synthesized proteins are transported to the plasma membrane for secretion through conventional or unconventional pathways. In conventional protein secretion, proteins are transported from the ER lumen to Golgi lumen and through various other compartments to be secreted at the plasma membrane, while unconventional protein secretion bypasses the Golgi apparatus. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) proteins are involved in cargo vesicle trafficking and membrane fusion. The ER localized vesicle associated SNARE (v-SNARE) protein Sec22 plays a major role during anterograde and retrograde transport by promoting efficient membrane fusion and assisting in the assembly of higher order complexes by homodimer formation. Sec22 is not only confined to ER–Golgi intermediate compartments (ERGIC) but also facilitates formation of contact sites between ER and plasma membranes. Sec22 mutation is responsible for the development of atherosclerosis and symptoms in the brain in Alzheimer’s disease and aging in humans. In the fruit fly Drosophila melanogaster, Sec22 is essential for photoreceptor morphogenesis, the wingless signaling pathway, and normal ER, Golgi, and endosome morphology. In the plant Arabidopsis thaliana, it is involved in development, and in the nematode Caenorhabditis elegans, it is in involved in the RNA interference (RNAi) pathway. In filamentous fungi, it affects cell wall integrity, growth, reproduction, pathogenicity, regulation of reactive oxygen species (ROS), expression of extracellular enzymes, and transcriptional regulation of many development related genes. This review provides a detailed account of Sec22 function, summarizes its domain structure, discusses its genetic redundancy with Ykt6, discusses what is known about its localization to discrete membranes, its contributions in conventional and unconventional autophagy, and a variety of other roles across different cellular systems ranging from higher to lower eukaryotes, and highlights some of the surprises that have originated from research on Sec22.
Microrna-130a Downregulates HCV Replication through an atg5-Dependent Autophagy Pathway
Authors: Duan Xiaoqiong , Liu Xiao , Li Wenting , Holmes Jacinta A. , Kruger Annie J. , Yang Chunhui , Li Yujia , Xu Min , Ye Haiyan , Li Shuang , Liao Xinzhong , Sheng Qiuju , Chen Dong , Shao Tuo , Cheng Zhimeng , Kaj Batul , Schaefer Esperance A. , Li Shilin , Chen Limin , Lin Wenyu , Chung Raymond T.
Published: April 2019

We previously identified that miR-130a downregulates HCV replication through two independent pathways: restoration of host immune responses and regulation of pyruvate metabolism. In this study, we further sought to explore host antiviral target genes regulated by miR-130a. We performed a RT² Profiler™ PCR array to identify the host antiviral genes regulated by miR-130a. The putative binding sites between miR-130a and its downregulated genes were predicted by miRanda. miR-130a and predicted target genes were over-expressed or knocked down by siRNA or CRISPR/Cas9 gRNA. Selected gene mRNAs and their proteins, together with HCV replication in JFH1 HCV-infected Huh7.5.1 cells were monitored by qRT-PCR and Western blot. We identified 32 genes that were significantly differentially expressed more than 1.5-fold following miR-130a overexpression, 28 of which were upregulated and 4 downregulated. We found that ATG5, a target gene for miR-130a, significantly upregulated HCV replication and downregulated interferon stimulated gene expression. miR-130a downregulated ATG5 expression and its conjugation complex with ATG12. ATG5 and ATG5-ATG12 complex affected interferon stimulated gene (ISG) such as MX1 and OAS3 expression and subsequently HCV replication. We concluded that miR-130a regulates host antiviral response and HCV replication through targeting ATG5 via the ATG5-dependent autophagy pathway.
On the Applicability of ATR-FTIR Microscopy to Evaluate the Blending between Neat Bitumen and Bituminous Coating of Reclaimed Asphalt
Authors: Margaritis Alexandros , Tofani Giorgio , Jacobs Geert , Blom Johan , Tavernier Serge , Vuye Cedric , Van den bergh Wim
Published: April 2019

The utilization of Reclaimed Asphalt (RA) in the road construction sector induces considerable economic and ecological benefits. The blending of the recycled material with new components is believed to be of great importance for the mixture’s properties. An extensive knowledge of the blending of the materials is crucial in optimizing the use of RA, especially at higher recycling rates. In this paper, the applicability of Fourier transform infrared (FTIR) microscopy in attenuated total reflectance (ATR) mode to study the bituminous coating of RA granulates is investigated. This method is a promising alternative to trace heterogeneous areas within the coating compared to methods that require extraction and recovery of bitumen. A method for sample preparation and FTIR spectra analysis is proposed. Four different samples were analyzed: a reference RA granulate, two types of RA granulates mixed with neat bitumen, and a RA granulate with rejuvenator. The results show that the use of ATR-FTIR microscope allows the tracing of different components, indications of blending, as well as proof of rejuvenation of the aged bituminous area.
Numerical Simulation of Failure of Composite Coatings due to Thermal and Hygroscopic Stresses
Authors: Zhou Helezi , Liu Hong-Yuan , Fu Kunkun , Yuan Hong , Du Xusheng , Mai Yiu-Wing
Published: April 2019

Due to the higher thermal and moisture expansions of epoxy coatings than the rigid substrate, these coatings suffer from high thermal and hygroscopic stresses, leading to coating/substrate interfacial crack growth. Herein, a parametric study was conducted systematically on epoxy coatings incorporated with fillers, in order to understand their effects on coating/substrate interface delamination caused by thermal and hygroscopic stresses. A finite element model (FEM) was developed to determine an indicator J-integral value (Ji), in comparison with a critical JC value to interpret the obtained interface delamination experimental results. FE simulations showed that interfacial pre-cracks located at coating edges were more serious than those at the centre. Once delamination was triggered by thermal shock or moisture absorption, it propagated rapidly along the coating/substrate interface. However, by adding suitable micro-/nano-fillers to the coating the thermal and hygroscopic stresses give lower Ji values, so that delamination crack growth can be effectively controlled. The simulation results demonstrate that the incorporation of fillers with lower Young’s modulus, lower thermal expansion and moisture absorption coefficients, smaller size for soft fillers, larger size for rigid fillers, and suitable aspect ratios for rod-shape fillers to the coatings, are more effective against interface delamination. Hence, useful guidelines for improving the design of epoxy composite coatings against delamination growth can be obtained for different engineering applications.
Decomposition Characterizations of Methane Hydrate Confined inside Nanoscale Pores of Silica Gel below 273.15 K
Authors: Wan Lihua , Zhou Xuebing , Chen Peili , Zang Xiaoya , Liang Deqing , Guan Jinan
Published: April 2019

The formation and decomposition of gas hydrates in nanoscale sediments can simulate the accumulation and mining process of hydrates. This paper investigates the Raman spectra of water confined inside the nanoscale pores of silica gel, the decomposition characterizations of methane hydrate that formed from the pore water, and the intrinsic relationship between them. The results show that pore water has stronger hydrogen bonds between the pore water molecules at both 293 K and 223 K. The structure of pore water is conducive to the nucleation of gas hydrate. Below 273.15 K, the decomposition of methane hydrate formed from pore water was investigated at atmospheric pressure and at a constant volume vessel. We show that the decomposition of methane hydrate is accompanied by a reformation of the hydrate phase: The lower the decomposition temperature, the more times the reformation behavior occurs. The higher pre-decomposition pressure that the silica gel is under before decomposition is more favorable to reformation. Thus, reformation is the main factor in methane hydrate decomposition in nanoscale pores below 273.15 K and is attributed to the structure of pore water. Our results provide experimental data for exploring the control mechanism of hydrate accumulation and mining.
Adaptive Synchronization Strategy between Two Autonomous Dissipative Chaotic Systems Using Fractional-Order Mittag–Leffler Stability
Authors: Liu Licai , Du Chuanhong , Zhang Xiefu , Li Jian , Shi Shuaishuai
Published: April 2019

Compared with fractional-order chaotic systems with a large number of dimensions, three-dimensional or integer-order chaotic systems exhibit low complexity. In this paper, two novel four-dimensional, continuous, fractional-order, autonomous, and dissipative chaotic system models with higher complexity are revised. Numerical simulation of the two systems was used to verify that the two new fractional-order chaotic systems exhibit very rich dynamic behavior. Moreover, the synchronization method for fractional-order chaotic systems is also an issue that demands attention. In order to apply the Lyapunov stability theory, it is often necessary to design complicated functions to achieve the synchronization of fractional-order systems. Based on the fractional Mittag–Leffler stability theory, an adaptive, large-scale, and asymptotic synchronization control method is studied in this paper. The proposed scheme realizes the synchronization of two different fractional-order chaotic systems under the conditions of determined parameters and uncertain parameters. The synchronization theory and its proof are given in this paper. Finally, the model simulation results prove that the designed adaptive controller has good reliability, which contributes to the theoretical research into, and practical engineering applications of, chaos.
Bogdanov Map for Modelling a Phase-Conjugated Ring Resonator
Authors: Aboites Vicente , Liceaga David , Jaimes-Reátegui Rider , García-López Juan Hugo
Published: April 2019

In this paper, we propose using paraxial matrix optics to describe a ring-phase conjugated resonator that includes an intracavity chaos-generating element; this allows the system to behave in phase space as a Bogdanov Map. Explicit expressions for the intracavity chaos-generating matrix elements were obtained. Furthermore, computer calculations for several parameter configurations were made; rich dynamic behavior among periodic orbits high periodicity and chaos were observed through bifurcation diagrams. These results confirm the direct dependence between the parameters present in the intracavity chaos-generating element.
Satellite Quantum Communications When Man-in-the-Middle Attacks Are Excluded
Authors: Vergoossen Tom , Bedington Robert , Grieve James A. , Ling Alexander
Published: April 2019

An application of quantum communications is the transmission of qubits to create shared symmetric encryption keys in a process called quantum key distribution (QKD). Contrary to public-private key encryption, symmetric encryption is considered safe from (quantum) computing attacks, i.e. it provides forward security and is thus attractive for secure communications. In this paper we argue that for free-space quantum communications, especially with satellites, if one assumes that man-in-the-middle attacks can be detected by classical channel monitoring techniques, simplified quantum communications protocols and hardware systems can be implemented that offer improved key rates. We term these protocols photon key distribution (PKD) to differentiate them from the standard QKD protocols. We identify three types of photon sources and calculate asymptotic secret key rates for PKD protocols and compare them to their QKD counterparts. PKD protocols use only one measurement basis which we show roughly doubles the key rates. Furthermore, with the relaxed security assumptions one can establish keys at very high losses, in contrast to QKD where at the same losses privacy amplification would make key generation impossible.
An Improved Model Equation Based on a Gaussian Function Trinomial for State of Charge Estimation of Lithium-ion Batteries
Authors: Linghu Jinqing , Kang Longyun , Liu Ming , Hu Bihua , Wang Zefeng
Published: April 2019

Establishing a model equation with high accuracy and high computational efficiency is very important for the estimation of battery state of charge (SOC). To ensure better SOC estimation results, most studies have focused on the improvement of the algorithm, while the impact of the model equation which may offset the benefits of advanced algorithms has been overlooked. To address this problem, this paper studies the widely used model equations and presents a new model equation based on a Gaussian function that improves the SOC estimation accuracy and computational efficiency. With the Worldwide harmonized Light Vehicles Test Cycle (WLTC) which is highly dynamic and more realistic than any other driving cycles, the proposed model equation is applied to different filtering algorithms to validate its performance in SOC estimation. The results indicate that the proposed model equation can greatly improve the accuracy of SOC estimation without an increase of computation. In addition, for the traditional polynomial-based model equations, the 6th-order power function polynomial has better performance in SOC estimation than polynomials with other orders.
On the Assessment of the 2030 Power Sector Transition in Spain
Authors: Gómez-Calvet Roberto , Martínez-Duart José M.
Published: April 2019

Recently, the European Union has recognized that more ambitious plans in reducing emissions are needed in order to comply with the target 1.5–2° warming limit for this century. Along this line, the main objective of this paper is to study the evolution of the power sector in Spain, taking into account the Paris Agreement and the further European Union Directives. In particular, we have studied the substitution by renewable energies of all coal power plants before 2030. For this study, we have applied linear programming techniques to optimize the deployment of the additional wind and solar resources. If, in addition to the substitution of coal power plants, we also consider the expected increase in demand for the period 2019–2030, we find that the present park of renewables should be increased by a factor of about 115%. We have also statistically analyzed the amount of surpluses and shortages in energy, assuming that the demand curve would have a daily shape similar to the present one. As a result, we have found that additional storage capabilities of around 55 GWh for 11 h would be needed in order not to waste more than 25% surplus energy by curtailment. As for backup, we propose in a first step to use the overwhelming amount of gas combined cycle units which are available.
Solar Irradiance Forecasts by Mesoscale Numerical Weather Prediction Models with Different Horizontal Resolutions
Authors: Ohtake Hideaki , Uno Fumichika , Oozeki Takashi , Hayashi Syugo , Ito Junshi , Hashimoto Akihiro , Yoshimura Hiromasa , Yamada Yoshinori
Published: April 2019

This study examines the performance of radiation processes (shortwave and longwave radiations) using numerical weather prediction models (NWPs). NWP were calculated using four different horizontal resolutions (5, 2 and 1 km, and 500 m). Validation results on solar irradiance simulations with a horizontal resolution of 500 m indicated positive biases for direct normal irradiance dominate for the period from 09 JST (Japan Standard Time) to 15 JST. On the other hand, after 15 JST, negative biases were found. For diffused irradiance, weak negative biases were found. Validation results on upward longwave radiation found systematic negative biases of surface temperature (corresponding to approximately −2 K for summer and approximately −1 K for winter). Downward longwave radiation tended to be weak negative biases during both summer and winter. Frequency of solar irradiance suggested that the frequency of rapid variations of solar irradiance (ramp rates) from the NWP were less than those observed. Generally, GHI distributions between the four different horizontal resolutions resembled each other, although horizontal resolutions also became finer.
Stability Control for Gob-Side Entry Retaining with Supercritical Retained Entry Width in Thick Coal Seam Longwall Mining
Authors: Zhang Zizheng , Yu Xianyang , Wu Hai , Deng Min
Published: April 2019

Taking gob-side entry retaining with large mining height (GER-LMH) of the 4211 panel in the Liujiazhuang coal mine as the engineering background, a numerical simulation was conducted to study the surrounding rock deformation, stress, and plastic zone distribution of GER-LMH with respect to retained entry width. The concept of critical retained entry width of GER-LMH was proposed. In view of the deformation characteristics of surrounding rock, an innovative approach to determine the critical width of GER-LMH based on the cusp catastrophe theory was proposed. The cusp catastrophe functions were set up by approximate roadside backfill body rib convergence and roof subsidence series with respect to different retained entry widths. The critical retained entry width of GER-LMH was 4.0 m according to bifurcation set equations. Surrounding rock stability control principle and technique of GER-LMH was proposed, including “rib strengthening and roof control”: road-in support with high pre-stress rockbolts and anchor cables, roadside backfill body construction technology with high-water quick consolidated filling materials and counter-pulled rockbolt, road-in reinforced support technology with hydraulic prop support and roof master. Field test and field monitoring results show that GER-LMH with supercritical retained entry width in the 4211 panel could meet the requirements for ventilation when the 4211 panel was retreating.
The Impact of Fuel Type on the Output Parameters of a New Biofuel Burner
Authors: Tucki Karol , Orynycz Olga , Wasiak Andrzej , Świć Antoni , Wichłacz Joanna
Published: April 2019

Intensified action aimed at reducing CO2 emissions and striving for energy self-sufficiency of both business entities and individual consumers are forcing the sustainable development of environmentally friendly and renewable energy sources. The development of an appropriate class of equipment and production technology is not without significance in this process. On the basis of a proven design for a combustion burner for ecological fuels, a new biofuel burner, also dedicated to prosumers’ energetics, was built. The aim of the study was to determine the effect of the type of biofuel on a burner’s output parameters, especially gaseous emissions, during the combustion of four types of fuels, including three types of biomass. The combustion temperature was measured for lignite, wood pellets, straw pellets, and sunflower pellets. An analysis of exhaust gas composition was performed for lignite and wood pellets. The results of exhaust emissions and combustion temperatures were compared with the burners currently in use. The use of a new burner might contribute to cleaner combustion and reducing the emissions of some gaseous components.
Two-Layer Routing for High-Voltage Powerline Inspection by Cooperated Ground Vehicle and Drone
Authors: Liu Yao , Shi Jianmai , Liu Zhong , Huang Jincai , Zhou Tianren
Published: April 2019

A novel high-voltage powerline inspection system was investigated, which consists of the cooperated ground vehicle and drone. The ground vehicle acts as a mobile platform that can launch and recycle the drone, while the drone can fly over the powerline for inspection within limited endurance. This inspection system enables the drone to inspect powerline networks in a very large area. Both vehicle’ route in the road network and drone’s routes along the powerline network have to be optimized for improving the inspection efficiency, which generates a new Two-Layer Point-Arc Routing Problem (2L-PA-RP). Two constructive heuristics were designed based on “Cluster First, Route Second” and “Route First, Split Second”. Then, local search strategies were developed to further improve the quality of the solution. To test the performance of the proposed algorithms, different-scale practical cases were designed based on the road network and powerline network of Ji’an, China. Sensitivity analysis on the parameters related to the drone’s inspection speed and battery capacity was conducted. Computational results indicate that technical improvement on the inspection sensor is more important for the cooperated ground vehicle and drone system.
Dynamic Simulation of the Crown Net Photosynthetic Rate for Young Larix olgensis Henry Trees
Authors: Liu Qiang , Xie Longfei , Li Fengri
Published: April 2019

Numerical integration of the instantaneous net photosynthetic rate (An) is a common method for calculating the long-term CO2 uptake of trees, and accurate dynamic simulation of the crown An has been receiving substantial attention. Tree characteristics are challenging to assess given their aerodynamically coarse crown properties, spatiotemporal variation in leaf functional traits and microenvironments. Therefore, the variables associated with the dynamic variations in the crown An must be identified. The relationships of leaf temperature (Tleaf), the vapor pressure deficit (VPD), leaf mass per area (LMA) and the relative depth into the crown (RDINC) with the parameters of the photosynthetic light-response (PLR) model of Larix olgensis Henry were analyzed. The LMA, RDINC and VPD were highly correlated with the maximum net photosynthetic rate (Amax). The VPD was the key variable that mainly determined the variation in the apparent quantum yield (AQY). Tleaf exhibited a significant exponential correlation with the dark respiration rate (Rd). According to the above correlations, the crown PLR model of L. olgensis trees was constructed by linking VPD, LMA and RDINC to the original PLR equation. The model performed well, with a high coefficient of determination (R2) value (0.883) and low root mean square error (RMSE) value (1.440 μmol m−2 s−1). The extinction coefficient (k) of different pseudowhorls within a crown was calculated by the Beer–Lambert equation based on the observed photosynthetically active radiation (PAR) distribution. The results showed that k was not a constant value but varied with the RDINC, solar elevation angle (ψ) and cumulative leaf area of the whole crown (CLA). Thus, we constructed a k model by reparameterizing the power function of RDINC with the ψ and CLA, and the PAR distribution within a crown was therefore well estimated (R2 = 0.698 and RMSE = 174.4 μmol m−2 s−1). Dynamic simulation of the crown An for L. olgensis trees was achieved by combining the crown PLR model and dynamic PAR distribution model. Although the models showed some weakened physiological biochemical processes during photosynthesis, they enabled the estimation of long-term CO2 uptake for an L. olgensis plantation, and the results could be easily fitted to gas-exchange measurements.
ORTHOSCOPE Analysis Reveals the Presence of the Cellulose Synthase Gene in All Tunicate Genomes but Not in Other Animal Genomes
Authors: Inoue Jun , Nakashima Keisuke , Satoh Noriyuki
Published: April 2019

Tunicates or urochordates—comprising ascidians, larvaceans, and salps—are the only metazoans that can synthesize cellulose, a biological function usually associated with bacteria and plants but not animals. Tunicate cellulose or tunicine is a major component of the outer acellular coverage (tunic) of the entire body of these organisms. Previous studies have suggested that the prokaryotic cellulose synthase gene (CesA) was horizontally transferred into the genome of a tunicate ancestor. However, no convenient tools have been devised to determine whether only tunicates harbor CesA. ORTHOSCOPE is a recently developed tool used to identify orthologous genes and to examine the phylogenic relationship of molecules within major metazoan taxa. The present analysis with this tool revealed the presence of CesA orthologs in all sequenced tunicate genomes but an absence in other metazoan genomes. This supports an evolutionary origin of animal cellulose and provides insights into the evolution of this animal taxon.
Establishment of a Greek Food Database for Palaeodiet Reconstruction: Case Study of Human and Fauna Remains from Neolithic to Late Bronze Age from Greece
Authors: Dotsika Elissavet , Diamantopoulos Georgios , Lykoudis Spyridon , Gougoura Sofia , Kranioti Elena , Karalis Petros , Michael Dimitra , Samartzidou Eleni , Palaigeorgiou Emmanouil
Published: April 2019

We review the stable isotopic data of recovered Greek bones from the Early Neolithic to the Late Bronze period in order to examine dietary changes over time. As an isotopic baseline we use the published fauna data of the periods. The analysis revealed a diet that included a significant proportion of foods based on C3 plants, and the bulk of the animal protein must have been provided by terrestrial mammals with a small but detectable proportion of marine protein for coastal and island populations. A more significant contribution of marine protein is observed for Bronze Age populations while the enrichment in both C and N isotopes is connected, for some areas, to the introduction of millet during the Bronze Age, and to freshwater consumption. An extensive database of Greek food sources is presented and compared to the fauna from the prehistoric periods (Early Neolithic to Late Bronze Age) of the literature. We propose that this database can be used in palaeodiet reconstruction studies.
Smart Restored by Learning Exercise Alleviates the Deterioration of Cognitive Function in Older Adults with Dementia—A Quasi-Experimental Research
Authors: Tseng Chi-Fen , Lee Shao-Huai , Hsieh Tsung-Cheng , Lee Ru-Ping
Published: April 2019

Maintaining cognitive function is essential for older adults with dementia. The purpose of this study was to investigate the effectiveness of Smart Restored by Learning Exercise (SRLE) on cognitive functions, neuropsychiatric symptoms, and frontal lobe functions in elderly people with dementia. A total of 68 older adults with dementia participated in this study. A quasi-experimental design was used, and convenience sampling and assignment approaches were adopted to select the participants for experimental and control groups. The experimental group engaged in SRLE for 6 months. The control group received routine care without SRLE. The participants’ cognitive function, neuropsychiatric symptoms, and frontal lobe function at baseline were evaluated using the Mini-Mental State Examination (MMSE), Neuropsychiatry Inventory (NPI), and Frontal Assessment Battery (FAB), respectively, in month 3 and month 6. The Group by Time interaction was statistically significant for MMSE and FAB scores, which indicated the different group effects between months 3 and 6. The results also showed that the improvement of MMSE, NPI, and FAB scores in the SRLE group were significantly better than the control group (t = −5.99~4.90, p < 0.001) at both months 3 and 6. In conclusion, long-term facilities may provide residents with SRLE every day to prevent a decline in the residents’ levels of cognitive function.
The Thermal Effects of Water Immersion on Health Outcomes: An Integrative Review
Authors: An Jiyeon , Lee Insook , Yi Yunjeong
Published: April 2019

Hydrotherapy is widely used for the treatment and rehabilitation of patients, but it can also be applied to prevent diseases in healthy people. This review investigates the health effects of water immersion, a form of hydrotherapy, and the mechanisms by which the properties of water elicit such an effect. We searched PubMed, EMBASE, Cochrane Library, and CINAHL to identify relevant articles, of which 13 met the inclusion criteria. Various factors of water immersion were investigated in the 13 selected articles, including water temperature, immersion height, and application area. With respect to health effects, warm and cold water immersion affects the cardiovascular and neuromuscular systems, respectively. Nine articles focused on the effects of warm water immersion, explaining its thermal effect in relation to changes in disease-related serum substance levels and hemodynamic changes. While the sample population in most studies comprised young adults, two articles applied partial water immersion to the legs of elderly subjects to assess its effect on sleep. Because the water immersion protocols applied in the 13 articles were inconsistent, the health benefits could not be clearly explained. However, we expect the present findings to be beneficial for providing research guidelines for studies on the application of water immersion.
Integration of Green Energy and Advanced Energy-Efficient Technologies for Municipal Wastewater Treatment Plants
Authors: Guo Ziyang , Sun Yongjun , Pan Shu-Yuan , Chiang Pen-Chi
Published: April 2019

Wastewater treatment can consume a large amount of energy to meet discharge standards. However, wastewater also contains resources which could be recovered for secondary uses under proper treatment. Hence, the goal of this paper is to review the available green energy and biomass energy that can be utilized in wastewater treatment plants. Comprehensive elucidation of energy-efficient technologies for wastewater treatment plants are revealed. For these energy-efficient technologies, this review provides an introduction and current application status of these technologies as well as key performance indicators for the integration of green energy and energy-efficient technologies. There are several assessment perspectives summarized in the evaluation of the integration of green energy and energy-efficient technologies in wastewater treatment plants. To overcome the challenges in wastewater treatment plants, the Internet of Things (IoT) and green chemistry technologies for the water and energy nexus are proposed. The findings of this review are highly beneficial for the development of green energy and energy-efficient wastewater treatment plants. Future research should investigate the integration of green infrastructure and ecologically advanced treatment technologies to explore the potential benefits and advantages.
The miRNA-Mediated Post-Transcriptional Regulation of Maize in Response to High Temperature
Authors: Zhang Moubiao , An Panpan , Li Hongping , Wang Xiuling , Zhou Jinlong , Dong Pengfei , Zhao Yali , Wang Qun , Li Chaohai
Published: April 2019

High temperature (HT) has recently become one of the most important abiotic stresses restricting crop production worldwide. MicroRNAs (miRNAs) are important regulators in plant development and stress responses. However, knowledge of miRNAs of maize in response to HT is limited. In this study, we simultaneously adopted miRNA sequencing and transcriptome profiling to analyze the differential expression of miRNAs and mRNAs in maize during exposure to HT stress. Our analysis revealed 61 known miRNAs belonging to 26 miRNA families and 42 novel miRNAs showing significant differential expression, with the majority being downregulated. Meanwhile, the expression of 5450 mRNAs was significantly altered in the same stressed tissues. Differentially expressed transcripts were most significantly associated with response to stress, photosynthesis, biosynthesis of secondary metabolites, and signal transduction pathways. In addition, we discovered 129 miRNA–mRNA pairs that were regulated antagonistically, and further depiction of the targeted mRNAs indicated that several transcription factors, protein kinases, and receptor-like-protein-related transmembrane transport and signaling transduction were profoundly affected. This study has identified potential key regulators of HT-stress response in maize and the subset of genes that are likely to be post-transcriptionally regulated by miRNAs under HT stress.
Serine/Threonine Protein Kinase STK16
Authors: Wang Junjun , Ji Xinmiao , Liu Juanjuan , Zhang Xin
Published: April 2019

STK16 (Ser/Thr kinase 16, also known as Krct/PKL12/MPSK1/TSF-1) is a myristoylated and palmitoylated Ser/Thr protein kinase that is ubiquitously expressed and conserved among all eukaryotes. STK16 is distantly related to the other kinases and belongs to the NAK kinase family that has an atypical activation loop architecture. As a membrane-associated protein that is primarily localized to the Golgi, STK16 has been shown to participate in the TGF-β signaling pathway, TGN protein secretion and sorting, as well as cell cycle and Golgi assembly regulation. This review aims to provide a comprehensive summary of the progress made in recent research about STK16, ranging from its distribution, molecular characterization, post-translational modification (fatty acylation and phosphorylation), interactors (GlcNAcK/DRG1/MAL2/Actin/WDR1), and related functions. As a relatively underexplored kinase, more studies are encouraged to unravel its regulation mechanisms and cellular functions.
The Cardioprotective Signaling Activity of Activated Protein C in Heart Failure and Ischemic Heart Diseases
Authors: Ren Di , Giri Hemant , Li Ji , Rezaie Alireza R.
Published: April 2019

Activated protein C (APC) is a vitamin-K dependent plasma serine protease, which functions as a natural anticoagulant to downregulate thrombin generation in the clotting cascade. APC also modulates cellular homeostasis by exhibiting potent cytoprotective and anti-inflammatory signaling activities. The beneficial cytoprotective effects of APC have been extensively studied and confirmed in a number of preclinical disease and injury models including sepsis, type-1 diabetes and various ischemia/reperfusion diseases. It is now well-known that APC modulates downstream cell signaling networks and transcriptome profiles when it binds to the endothelial protein C receptor (EPCR) to activate protease-activated receptor 1 (PAR1) on various cell types. However, despite much progress, details of the downstream signaling mechanism of APC and its crosstalk with other signaling networks are far from being fully understood. In this review, we focus on the cardioprotective properties of APC in ischemic heart disease and heart failure with a special emphasis on recent discoveries related to the modulatory effect of APC on AMP-activated protein kinase (AMPK), PI3K/AKT, and mTORC1 signaling pathways. The cytoprotective properties of APC might provide a novel strategy for future therapies in cardiac diseases.