bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychobiological Predictors of Sexual Function in Patients with Prostate Cancer After Radical Prostatectomy
Authors:   Faculty of Psychology and Educational Sciences, University of Porto, Porto, Portugal, Nobre P. J. , Quinta Gomes A. L. ,   Faculty of Psychology and Educational Sciences, University of Porto, Porto, Portugal, Janssen E. ,   Institute for Family and Sexuality Studies, Ku Leuven, and The Kinsey Institute, Leuven, Belgium, Adaikan G. ,   Yong Loo Lin School of Medicine, National University of Singapore, National University Hospital, Singapore, Singapore
Published: November 2020

Objective: The objective of the present study is to test the effect of psychological trait dimensions (e.g., personality dimensions, sexual beliefs, sexual inhibition and sexual excitation), along with medical dimensions, in sexual function recovery in men with prostate cancer after radical prostatectomy. Design and Method: Over a 12 month period, 75 men diagnosed with prostate cancer and pending for radical prostatectomy with bilateral nerve sparing will be assessed four times (before surgery and at 3, 6, and 12 months after surgery) in order to examine the role of psychobiological dimensions in the evolution of different dimensions of sexual function (sexual desire, erectile function, and orgasm). Eligible participants will be presented with the study’s objectives and procedures and if agree to participate voluntarily in the study will give their written consent. A clinical interview will be conducted individually with each participant and a battery of self-reported questionnaires will also be filled out by the participants in each assessment session. Results: Given the particular impact of radical prostatectomy in men’s sexual functioning, particular aspects regarding the interplay between psychological and medical factors in determining the recovery of sexual function in men with prostate cancer will be discussed. Conclusions: This study has important clinical implications for the future management of sexual problems associated with prostate cancer and related treatments, and have important implications for the sexual health, general and emotional wellbeing of patients with cancer.
The Investigation of Penile Length with Newborn Circumcision and Second to Fourth Digit Ratio
Authors:   Chonbuk National University Hospital, Jeonju, South Korea, Park J. , Lee S. ,   Sungkyunkwan University Samsumg Seoul Hospital, Seoul, South Korea, Yang S. ,   Konkuk Uinversity School of Medicine, Chungju, South Korea, Shin Y. ,   Chonbuk National University Hospital, Jeonju, South Korea
Published: November 2020

Objective: We retrospectively investigated the relationship between newborn male circumcision (NMC) and second to fourth digit ratio with penile length in young adult. Design and Method: We evaluated that the patients who had history of the circumcision at past visited our hospital for urological treatment. The age at which the circumcision had been done was assessed. The patients’ heights and weights were measured. Second to fourth digit ratio was calculated by measuring the second and fourth digit lengths. The flaccid and erectile penile lengths were measured from the base of the penis to the tip of the glans in standing position. Results: A total of 248 patients finished our study. The subjects were divided into two groups, including 72 patients in the NMC group, and 176 patients in the non-NMC group. In univariate analysis, height, second to fourth digit ratio, flaccid penile length and age of circumcision were associated with erectile penile length. Flaccid (p<0.001) and erectile (p=0.001) penile lengths were shorter in the NMC group than in the non-NMC group. Among these variables, second to fourth digit ratio, flaccid penile length and age of circumcision were a significant predictive factor for erectile penile length in multivariate analysis. Conclusions: Second to fourth digit ratio, flaccid penile length and the age of circumcision were significant predictive factors for erectile penile length. Furthermore, penile lengths were shorter in the NMC group than in the non-NMC group.
Sexuality of Pregnant Women
Authors:   Centro Universitário Adventista de São Paulo, São Paulo, Brazil, Castelão Fernandes T. , Protti F. ,   Grupo de Estudos e Pesquisas do Inpasex, São Paulo, Brazil, Belz P. ,   Clínica Psicológica, São Paulo, Brazil
Published: November 2020

Objective: Pregnancy is a very special time in women’s life, because it is a period that involves a lot of biological, psychological and relationship changes with their partners. It is in this context of changes that sexuality can be profoundly affected. This research investigates these changes in women sexuality during pregnancy. Design and Method: This is a qualitative and descriptive research that used the study of clinical cases. For this research, there was a group of married women that joined the program. The women were between 25 and 40 years old and got pregnant in the years 2014 and 2015. Results: The results indicate that the main changes in sexuality were: decreased sex drive, insecurities with physical appearance and attractiveness, partner’s jealousy, lack of affection, absence or reduction in the frequency of intercourse, pain during sexual intercourse, fear of not being desired by the spouse, difficulties in reconciling the roles of mother and wife, afraid that the penetration hurts the baby, anxiety about childbirth and concerns with the ideal of being a good mother. Conclusions: Pregnant women experience significant changes in sexuality during pregnancy. These changes can be mitigated with psychological care support, where women may reflect on their fears and anxieties, and to strengthen their selfconfidence and self-esteem. The participation of the partner in this period is crucial, including psychological counseling for the couple. Although it is a time of strong emotions, pregnancy may foster sexual experience and increase the complicity of the partners.
Sexting, Self-Esteem, Body Image: Sexual Health in a Sample of Young Women in Italy
Authors:   Department Of Humanities, Social And Health, University of Cassino And The Southern Lazio, Cassino, Italy, Verrastro V. , Fontanesi L. ,   Department of Development Processes And Socialization, University of Rome La Sapienza, Rome, Italy, Petruccelli I. ,   Department Of Humanities And Social Sciences, University Kore, Enna, Italy, Diotaiuti P. ,   Department Of Humanities , Social And Health, University of Cassino and The Southern Lazio, Cassino, Italy, Saladino D. ,   Institute For The Study of Psychotherapies, Rome, Italy
Published: November 2020

Objective: The present research aims to identify the relation between at risk on-line behaviour (as sexting), self-esteem and the influence of media on bodyimage. According to the literature, our hypothesis suggests that on line behavior is influenced by self-esteem and body-image perception. Design and Method: 500 female participants (range 14-25) filled out self-report questionnaires about socio-anagraphical information, health and sexual behaviour (a.e. BMI, contraception, sexual experiences). Italian versions of Sexting Behaviour Scale, Sociocultural Attitudes Towards Appearance Questionnaire-3 and Multidimensional Self Concept Scale, Cyberbulliyng Questionnaire were administered too. Results: Our results suggest that there are several differences between female adolescents and young adult women, especially for what concern sexual health and body image perception. Higher scores in the Sexting Behaviour Scale were associated with higher scores in the SATAQ subscales concerning internalization, suggesting that they perceive their body as not in shape as they want it to be. Moreover, we found that having a strong self-esteem was a protective factor from the pressure of TV and Magazines. Conclusions: Our results highlighted the relation between on line and offline sexual health, self-esteem and the influence of media on self-perception. Adolescents should be considered at high risk for development of psychological and health problem related to on line behaviour. Therefore it is extremely important for prevention to focus on intervention in schools to enhance self-efficacy in girls and young women, and to develop specific programs to show the risk of the use of internet.
The Mapping of Quality Tourists Prospects for Indonesia’s Tourism Markets
Authors: Maulana Addin , Koesfardani RR Chamma Fitri Putri Pradjwalita , Richard Alan Amory I Dewa Gede
Published: November 2020

The research aimed to identify which countries could be segmented as a potential tourism market for Indonesia to increase quality tourists. The researchers used quantitative methods with descriptive statistical analysis techniques to describe the average expenditure per visit and the length of stay. It was conducted by modifying the quadrant model. The result shows that there are countries included in the market with the prospect of quality tourists. Those are Saudi Arabia, Netherlands, Sweden, Switzerland, Belgium, Russia, France, Germany, Austria, Finland, Italy, Spain, Norway, Denmark, Canada, United Kingdom, New Zealand, USA, Portugal, Egypt, Pakistan, and Australia. The government needs to optimize those countries to become the main market. Therefore, the revenue from the tourism sector can be better optimized.
FATTY ACIDS ANALYSIS AND CHEMOTAXONOMIC CONSIDERATIONS OF MALVOIDEAE (MALVACEAE) SPECIES
Authors: Fernandes Diégina , Chaves Otemberg , Teles Yanna , Agra Maria , Vieira Maria , Silva Paulo , Marques Marcia , Souza Maria
Published: November 2020

Previous researches showed that fatty acids analysis might be a useful tool to support the taxonomic investigation. In this approach the fatty acids content of ten Malvoideae species was analyzed and its chemotaxonomic significance has been investigated. The aerial parts of the species were collected in the Northeast of Brazil and their fatty acid methyl esters were analyzed by gas chromatography with flame ionization detector. The chemometric analysis consisted of principal component analysis (PCA) and hierarchical clustering analysis (HCA) with the euclidean distance between the samples given by the Ward.D2 algorithm. This is the first report of fatty acids from Wissadula peripocifolia, Herissantia crispa, Bakeridesia pickelii, Sidastrum micranthum, Pavonia cancellata and Pavonia malacophylla. The results showed the predominance of palmitic (C16:0), oleic (C18:1) and linoleic (C18:2) acids in the studied species. By the PCA and HCA analysis, the fatty acid composition was able to distinguish the species Herissantia crispa and Pavonia malacophylla. Our findings showed a chemotaxonomic proximity among species from different genera reflecting the taxonomic and phylogenetic closeness previously demonstrated by molecular investigations on Malvoidae species. Furthermore, our results demonstrated that the fatty acid analysis may be an interesting tool to support the taxonomic investigations on Malvoideae species.
Study of the CuII Affinity by Three Chelating Agents of Biological Interest: TPEN, TRIEN and Et2DTC
Authors: Valle Eliana , Maltarollo Vinicius , Princhak Thiago , Honorio Kathia , Cerchiaro Giselle
Published: November 2020

Copper is an important micronutrient, and it is present in some protein structures, as well as participate in several important biological processes. Due to its importance, some ligands are used and studied like carriers of copper in the biological systems. This work has investigated the affinity of CuII by three ligands of biological interest: N,N,N,N’-tetrakis (2-pyridilmethyl) ethylenediamine (TPEN), triethylenetetramine (TRIEN), and diethyldithiocarbamate (Et2DTC), used for this purpose. The studies were performed by evaluating the CuII d-d band when complexed with these three ligands. The CuII d-d band in aqueous solution appears around 800 nm; when in the presence of TRIEN, this band displaces to 576 nm. TRIEN ligand is substituted by TPEN ligand (d-d band at 689 nm), and finally, in the presence of the Et2DTC ligand, the d-d band displaces to 665 nm. Theoretical calculations were used to obtain the binding energy and the values obtained were −481.85 kcal mol−1 for the CuII-TPEN, −417.80 kcal mol−1 for CuII-TRIEN and −726.72 kcal mol−1 for CuII-Et2DTC. Electrochemical studies showed an oxidation peak at 0.008 V to CuII-TRIEN complex, −0.135 V to CuII-TPEN and 0.150 V to CuII-Et2DTC. These results showed that CuII has a higher affinity by the Et2DTC ligand compared to the other ligands studied.
Efecto de la adición de β-mananasa sobre el consumo de alimento, producción, composición y contenido de células somáticas en leche de vacas Holstein-Friesian
Authors: López-Ordaz Rufino , Sánchez-López Florencia , Sánchez del Real Carlos , Lara-Bueno Alejandro , López-Ordaz Reyes , Ruiz-Flores Agustín
Published: November 2020

Introducción: El objetivo del presente estudio, fue evaluar el efecto de la adición de β-mananasa sobre el consumo de materia seca (CMS) en los periodos pre y posparto, la producción (PL) y calidad de la leche, el contenido de nitrógeno ureico (NU), y el conteo de células somáticas (CCS) en leche de vacas Holstein-Friesian.Método: En el estudio se utilizaron 30 vacas (Peso vivo (PV)=781±83 kg; de más de dos lactancias) de aproximadamente 260 d de gestación, las cuales se estratificaron por PV y PL en la lactancia previa y se asignaron aleatoriamente a uno de dos tratamientos: 1) Dieta completa (Maíz-ensilado de Maíz), Control; y 2) Control+0.10% de β-mananasa (CTCZYME; Seoul, South Korea).Resultados: El CMS preparto no fue diferente (14.44±0.70 vs 15.66±0.70 kg d-1; p>0.05) entre tratamientos. En el posparto, de manera similar, no hubo diferencias (p>0.05) entre las vacas complementadas con las enzimas y las vacas Control. Por el contrario, PL fue mayor (42.66±1.31 vs 38.24±1.31 kg vaca-1 d-1; p<0.05) en las vacas complementadas comparadas con las Control. La adición de B-mananasa no alteró (p>0.05) ninguno de los componentes de la leche. Por el contrario, las vacas que se alimentaron con la enzima fueron más eficientes (p<0.05) en producción de leche comparadas con las Control. Paralelamente, el CCS fue menor (152,600±294.1 vs 1´112,6400±294.1 células coliformes por mL; p<0.05) en las vacas que recibieron enzimas.Discusión o Conclusión: La adición de β-mananasa a dietas con Maíz-ensilado de Maíz, incrementó la producción de leche y disminuyó el contenido de células somáticas en la leche. No influyó en el consumo de materia seca en los periodos pre- y posparto, la composición de la leche producida y en el contenido de nitrógeno ureico en leche.
Evaluation of Filtering Techniques applied to simulated Electroencephalogram signals for Visual Evoked Potential Detection
Authors: Montalvo-Aguilar Jesús Alejandro , Bazán Ivonne , Ramírez-García Alfredo
Published: November 2020

Introduction: In this paper, it is presented an assessment of different windowing techniques and denoising methods applied to detect the Visual Evoked Potential (VEP) contained into the electroencephalographic (EEG) signals. The objective is to analyze advantages and disadvantages of each technique performance to identify correctly the VEP waveform and to quantify the latency which is a parameter commonly used as an indicator of ocular diseases.                       Method: Assessment of techniques was performed considering rigorous controlled conditions on the signal set, to assure that obtained results were linked just to the technique performances and avoid any undesirable effect due to the natural interference of acquisition of signals. For this reason, a simulated signals set was created based on a typical VEP waveform commonly registered around 100ms after an external stimulus was applied in the routine clinical study. Additionally, two evaluation stages were considered: fixed latency parameters stage and random latency parameters stage.Results: The best results without filter was with rectangular window and the use of elliptic filter can help to extract the VEP with a rectangular window too. For wavelet denoising the best result is Biorthogonal 2.6 wavelet with a Hamming window.                       Discussion or Conclusion: Five parameters were proposed to assessment the VEP extraction performed: signal noise ratio (SNR) mean square error (MSE), average latency (AL), latency standard deviation (LSD) and latency correlation variance (LCV) as representative factors to be considered on evaluations of VEP extraction methods. SNR and MSE were focused to assess the level of noise that remain in signal after windowing & denoising method was applied. In the other hand AL, LSD and LCV were oriented to evaluate the impact of the method on the VEP latency estimation.
Biomarker Analysis Based Chemoprofiling of Polyherbal Ayurvedic Formulation Containing Vitis vinifera L. by Validated UPLC-MS/MS Method
Authors: Goel Prerna , Aeri Vidhu , Dewangan Rikeshwer Prasad , Rub Rehan Abdur
Published: November 2020

Background:

Drakshasava is one of the commercial Ayurvedic medicines from India,
prepared from grapes and spices. It is believed to address health imbalances and claimed to be
beneficial for weakness, bleeding disorders, and various inflammatory diseases. It has been
reported to possess pharmacological activities such as diuretic, cardioprotective, and antimicrobial.
Being a polyherbal mixture, it faces challenges in its standardization and quality control.

Objective:

The aim of the present study is to develop a validated UPLC-MS/MS method for
simultaneous quantification of 10 polyphenolic biomarkers in Drakshasava. It explores the effect
of Vitis vinifera L. and additional herbs on fermentation with respect to bioactive compounds
through the successive addition method.

Methods:

The MS methods were optimized in multiple-reaction monitoring (MRM) mode with
ESI while chromatographic separation was achieved on an Acquity UPLC BEH C18 column using
both isocratic and gradient elution in water and acetonitrile containing 0.1% formic acid.

Results:

The developed method was validated as per ICH-Q2B guidelines and found to be within the
assay variability limits. Gallic acid was found to be the most abundant marker in all the samples
followed by resveratrol. The content of all the markers has been found to be increased significantly
post-fermentation, compared to decoction except kaempferol. The successive addition of prashpeka
drvya (minor herbs) in the formulation showed variability at different stages with respect to the
selected markers and did not exhibit major changes in the chemical profiling of the final product.

Conclusion:

The developed method was found to be rapid, accurate, reliable, and highly sensitive
for the simultaneous quantification of selected biomarkers in Drakshasava. The research is the first
chemometric report on the standardization of Drakshasava by validated UPLC-MS/MS method. It
may prove to be a useful tool for the development of new phytopharmaceutical drugs and further
quality control of other polyherbal formulations.
Efficient One-Pot Synthesis of 3-Substituted Phthalides via Additive Arylation of Organozinc Intermediate
Authors: Tonk Rajiv Kumar , Yadav Vivek , Hasan Mohsin
Published: November 2020

In recent years, substitution at the third position on phthalides has been proven a valuable
synthetic intermediate for developing active molecules. We reported a direct and efficient onepot
method for the synthesis of 3-aryl Phthalides performed by adding organo-zinc reagent on
methyl-2-formylbenzoate; reagent formed in-situ by the reaction between diethylzinc and different
aryl boronic acid derivatives without using any ligand. The possible mechanism involved a coordinated
zinc carbonyl transition state, arylation, and followed by the intramolecular cyclization. The
substituents groups in boronic having different electronic and steric properties played an important
role in the reaction completion time and yield. The structure elucidation and confirmation of the
synthesized compounds were done by using H-NMR analytical data. The method can be useful for
synthesizing various scaffolds and intermediates in search of potentially active compounds.
Computational Investigation of Zerumbone as an Inhibitor of TNF-alpha Using Molecular Dynamics and Molecular Docking Methods
Authors: Singh Salam Pradeep , Nongalleima Khumukcham , Singh Ningthoujam Indrajit , Chanu Wahengbam Kabita , Singh Thiyam Ramsing , Singh Chingakham Brajakisor
Published: November 2020

Background:

There are several reports on the anti-cancer property of zerumbone, such
as in breast, cervical and ovarian cancer. But the investigation of the actual protein target has been
the least concerned and there are few reports on the inhibitory effect of zerumbone against specific
cancer-causing proteins and enzymes. Therefore, further investigation is required at a much deeper
molecular level.

Objective:

This study aimed to determine the anti-proliferative activity of Zerumbone against cervical
cancer cell and assess its TNF-α enzyme inhibitory action.

Methods:

The investigation emphasized the anti-cancer activity of zerumbone against HeLa cells
and its subsequent TNF-α assay. Furthermore, computational studies on Zerumbone as an inhibitor
of TNF-α were carried out using computational techniques such as docking and MD simulations.

Results and Discussion:

From the molecular docking analysis, it was observed and substantiated
that the α,β-Unsaturated carbonyl scaffold is the main driving force for anti-cancer activity of
zerumbone and inhibition of TNF-α.

Conclusion:

Zerumbone might be a potent anti-cancer agent targeting the HeLa cancer cell lines
and inhibiting the TNF-α enzyme.
Nigella Sativa (Black Seeds), A Potential Herb for the Pharmacotherapeutic Management of Hypertension - A Review
Authors: Maideen Naina M.P. , Balasubramanian Rajkapoor , Ramanathan Sambathkumar
Published: November 2020

:

Hypertension is one of the leading risk factors for stroke, myocardial infarction and untimely
death. The prevalence of hypertension is extremely high among the global population, and
many of them depend on modern medicines to manage their blood pressure. The modern antihypertensive
medications include angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor
blockers (ARBs), calcium channel blockers (CCBs), diuretics, beta-adrenergic blockers, direct
renin inhibitors, direct-acting vasodilators, alpha-adrenergic blockers and centrally acting
drugs that are associated with many harmful and undesirable effects. The patients may consider traditional
herbal medicines as a good strategy to manage chronic conditions due to the reasons such
as perceived failure of allopathic medicines, relatively high cost of allopathic medicines, social-cultural
practices and/or herbal knowledge, poor access to medical facilities and safety concerns about
modern medicines. Nigella sativa (Black seeds) has been used to treat various conditions, including
hypertension, obesity, diabetes, cancer, etc. Hence, the antihypertensive potential of N. sativa is
analyzed in this review. The literature was searched in databases including Medline/PMC/PubMed,
Google Scholar, ScienceDirect, Directory of Open Access Journals (DOAJ) and reference lists to
identify articles associated with antihypertensive properties of N.sativa. Numerous randomized controlled
trials and animal studies reported that N.sativa has potential antihypertensive effects.
Hence, N. sativa could be used effectively to manage patients with stage 1 hypertension, and the patients
using modern antihypertensive medications could reduce their doses by adding N. sativa into
their regimen as adjuvant therapy.
Novel Somatic Mutations of the CDH1 Gene Associated with Gastric Cancer: Prediction of Pathogenicity Using Comprehensive In silico Methods
Authors: Chakraborty Payel , Ghatak Souvik , Yadav Ravi Prakash , Mukherjee Subhajit , Chhakchhuak Lalchhandama , Chenkual Saia , Zomuana Thomas , Lalruatfela Sailo Tlau , Maitra Arindam , Kumar Nachimuthu Senthil
Published: November 2020

Background::

Mutations in the CDH1 and the role of E-cadherin proteins are well
established in gastric cancer. Several in silico tools are available to predict the pathogenicity
of the mutations present in the genes with varying efficiency and sensitivity to detect the
pathogenicity of the mutations.

Objective::

Our objective was to identify somatic pathogenic variants in CDH1 involved in
Gastric Cancer (GC) by Sanger sequencing as well as using in silico tools and to find out
the best efficient tool for pathogenicity prediction of somatic missense variants.

Methods::

Sanger sequencing of CDH1 was done for 80 GC tumor and adjacent normal tissues.
Synthetic data sets were downloaded from the COSMIC database for comparison of
the known mutations with the discovered mutations from the present study. Different algorithms
were used to predict the pathogenicity of the discovery and synthetic mutation datasets
using various in-silico tools. Statistical analysis was done to check the efficiency of
the tools to predict pathogenic variants by using MEDCALC and GraphPad.

Results::

Six missense somatic variants were found in exons 3, 4, 7, 9, 12 and 15. Out of the
6 variants, 5 variants (chr16:68835618C>A, chr16:68845613A>C, chr16:68847271T>G,
chr16:68856001T>G, chr16:68863585G>C) were novel and not reported in disease variant
databases. PROVEAN, Polyphen 2 and PANTHER predicted the pathogenicity of the variants
more efficiently in both the discovery and synthetic datasets. The overall sensitivity of
predictions ranged from 60 to 80%, depending on the program used, with specificity from
55 to 100%.

Conclusion::

This study estimates the specificity and sensitivity of prediction tools in predicting
novel missense variants of CDH1 in Gastric Cancer. We report that PROVEAN,
Polyphen 2 and PANTHER are efficient predictors with constant higher specificity and accuracy.
This study will help the researchers to explore mutations with the best pathogenicity
prediction tools.
Taraxacum officinale Extracts Exhibit Safe and Selective Anticancer Activity
Authors: Al-Eisawi Zaynab , Abderrahman Salim M. , Al-khalaf Islam F. , Al-Abbassi Reem , Bustanji Yasser K.
Published: November 2020

Background:

Medicinal plants have been and continue to be the primary source of treatment for many diseases. Taraxacum officinale (dandelion), has been used for hundreds of years as a traditional medical remedy for several diseases. However, the anti-cancer potential of this plant has not been fully screened. Genotoxicity screening which is an integral part of the evaluation of the safety of this plant is also lacking.

Objective:

The aim of this study was to investigate the cytotoxic and genotoxic effects of different extracts of T. officinale.

Method:

Plant sample was extracted in different solvents to prepare ethanol, methanol, chloroform and water extracts. These extracts were then tested for their ability to inhibit the proliferation of colorectal cancer (Caco-2), chronic myelogenous leukemia (K562), prostate cancer (PC-3), and breast cancer (MCF-7) cells. Cell viability was evaluated using MTT assay and the selectivity indices was determined with the aid of mortal human fibroblasts. Then the most active extract, chloroform extract, was used to detect the genotoxicity of the constituents on mice bone marrow cells.

Results:

The results showed that the T. officinale chloroform extract was found to be most effective against leukemia (K562) and prostate cancer (PC-3) cell lines. The extracts showed marked selectivity towards these cancer cells. Genotoxic studies revealed that genotoxic changes occurred after chloroform extract treatment, however, these changes were observed at the very high concentrations only.

Conclusion:

The results suggest that T. officinale exhibits selective anti-tumor activity and it is safe for use.
Does Hypofractionated Radiotherapy Regimens Increase the Vulnerability to SARS- COV-2 by Influencing ACE-2 Activity?
Authors: Cherkaoui Ghofrane Salhi , Taleb Sara , Kadil Youness , Filali Houda
Published: November 2020

In the context of the novel Coronavirus pandemic due to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), the management of patients with cancer constitutes a real challenge.
These patients are more likely to be immunocompromised due to the underlying malignancy or
anticancer treatments. As a consequence, they are more at risk of contracting this virus and tend to show
a higher rate of fatal cases. In order to reduce the risk of this pandemic among patients and health care
professionals, oncologists are currently proposing hypofractionated radiotherapy regimens using higher
doses per fraction, thus shortening treatment courses and saving treatment visits. Since higher doses of
radiation may also increase the ACE/ACE2 activity, which has been identified as a key SARS-CoV-2
receptor, this paper raises the question of whether hypofractionated radiotherapy regimens further increase
the infectivity of these already vulnerable patients.
Novel Coronavirus Disease 2019 (COVID-19) Current Update: Perspective on Epidemiology, Diagnosis, Drug Targets and Vaccines
Authors: Harer Sunil L. , Sonar Priyanka A.
Published: November 2020

Background::

A novel coronavirus disease, 2019-nCoV (COVID-19), was reported first in Wuhan, the capital of Hubei, China, in late December 2019 and subsequently reached pandemic level affecting around 213 countries. As of 24th May 2020, the total number of positive cases confirmed is 5,446,514 and 344,754 death reports worldwide. COVID-19 infection causes pneumonialike severe respiratory infection and acute lung failure. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA beta coronavirus that is a confirmed causative agent of COVID-19. SARS-CoV-2 may use angiotensin-converting enzyme 2 (ACE2), unlike the receptor utilized by SARS-CoV (emerged in 2002) to infect humans. People with a history of hypertension, chronic obstructive pulmonary disease, diabetes, cardiovascular disease are more susceptible to SARS-CoV-2.

Objective::

The purpose of this review was to help the society to distinguish and deal with SARSCoV- 2, and make available a reference for forthcoming studies.

Methods::

Recently, diagnostic primer sets on the SARS-CoV-2 genome have been identified. The receptor-binding domain of SARS-COV-2 highlighted the mode by which beta-CoV recognizes ACE2. Various diagnostic tools are available to differentiate and identify SARS-CoV-2 infection as RT-PCR, antigen detection assay, and antibody detection assay. Different strategies have been employed to control the SARS-CoV-2, considering various drug targets like the main protease (3- CLPro), papain-like protease (PLpro), helicase (NSP13), RNA dependent RNA polymerase (RdRp), and viral envelope (E) protein.

Conclusion::

In the present review, we have updated details of transmission, pathogenesis, genome structure, diagnostic criteria, clinical characteristics, therapeutics, and vaccine development of the SARS-CoV-2 infection, which may be significant in the control and response to the COVID-19 outbreak.
Translating for children in the Arab world: an exercise in child political socialization
Authors: Mdallel Sabeur
Published: November 2020

Translating under the Arab dictatorships is a perilous task, as censorship bodies control all means and forms of expression. This is particularly true for children’s literature, which is a powerful tool of political socialisation. Al-Hajji’s Guide to Arab children's literature, translated in the Arab world from 1950 to 1998, shows that no book that undermines the dominant ideology has ever been translated in this geographical context. However, if a book chosen for translation contains some elements that might be viewed as subversive, strategies are adopted that automatically annihilate any threat. This paper focuses on the Arabic translation of Anna Sewell’s Black Beauty, published in Syria in 1991, to which elements have been added that were never envisaged by the original author.
Measuring censorship?: determining the level of “censoredness” of films subtitled during the dictatorship in Portugal
Authors: Pieper Katrin
Published: November 2020

During the Portuguese Estado Novo (1933-1974), many films were banned and others mutilated by the cutting of scenes and suppression and manipulation of subtitles. What reached the audience, in many cases, was a cleansed version of the original. A quick look into censorship documents shows how many cuts a film might have suffered. Suppressed subtitles are also relatively easy to detect. Yet, to get a complete picture, one has to take a deeper look at the subtitles, comparing them with the original spoken dialogues to detect ideological manipulations on the linguistic level. But how can one tell if a film was heavily or slightly censored? Is “censoredness” comparable? This article sets out to find an answer to the question of whether these measures are objectively describable and structurable, and if so, how the level of “censoredness” of subtitled films can be determined, with a view to allowing a larger-scale comparison of films.
A tradução de poesia nos períodos ditatoriais em Itália e Portugal
Authors: Cacchioli Serena
Published: November 2020

O presente estudo configura-se como uma investigação, do ponto de vista comparatista, sobre a tradução de poesia durante os períodos ditatoriais do século XX, em Itália e Portugal. O papel da tradução de poesia estrangeira como vector de mudanças sociais e como factor incidente nas dinâmicas socioculturais durante os períodos de forte repressão política é o foco desta investigação. As balizas temporais, para cada um dos países, são diferentes; é, no entanto, possível identificar elementos comuns relacionados especificamente com a tradução de poesia como forma de resistência à autoridade cultural, à cultura hegemónica imposta pelos regimes e à censura. A investigação demonstra como esta actividade pôde ser um dos meios de transmissão de mensagens revolucionárias em tempos de extrema repressão. O estudo concentra-se, em particular, num corpus reduzido de revistas italianas e portuguesas e extrai os elementos comuns relacionados com a tradução de poesia como meio de contestação à ditadura.
Money Management Behavior and Issues among Congolese University Students: Requirement for Educational Finance
Authors: Chinyabuuma Vigoureux , Suprapto Suprapto , Romadhon Muhammad Imron
Published: November 2020

Abstract: This study investigated the factors that influence a number of financial issues students face in the Democratic Republic of Congo. A survey was conducted to collect the data for this study. Respondents were asked to demonstrate which of the ten financial education topics they were keen on taking. Descriptive statistics was utilized to present the data. The results show that loans, residential status, and impulse spending were the causes that brought about the students’ financial issues. By identifying the causes of students’ financial issues, educators may be able offer a course, in which students can learn the money management skills needed to address these issues. The respondents were asked if they would be interested in financial education if offered. Almost all of the students expressed their interest in learning how to manage their money. In conclusion, many of the respondents did not have sufficient knowledge and skills in managing their financial affairs.Keywords: financial issues, loans, residential status, impulse spending, money management Perilaku dan Masalah Pengelolaan Uang di Kalangan Mahasiswa Universitas Kongo: Kebutuhan Keuangan PendidikanAbstrak: Penelitian ini menyelidiki faktor-faktor yang mempengaruhi sejumlah masalah keuangan yang dihadapi siswa di Republik Demokratik Kongo. Sebuah survei dilakukan untuk mengumpulkan data untuk penelitian ini. Responden diminta untuk menunjukkan yang mana dari sepuluh topik pendidikan keuangan yang mereka minati. Statistik deskriptif digunakan untuk menyajikan data. Hasil penelitian menunjukkan bahwa pinjaman, status tempat tinggal, dan pengeluaran impulsif merupakan penyebab yang menimbulkan masalah keuangan siswa. Dengan mengidentifikasi penyebab masalah keuangan siswa, pendidik mungkin dapat menawarkan kursus, agar siswa dapat mempelajari keterampilan pengelolaan uang yang diperlukan untuk mengatasi masalah ini. Para responden ditanya apakah mereka akan tertarik dengan pendidikan keuangan jika ditawarkan. Hampir semua siswa menyatakan minatnya untuk mempelajari cara mengelola uang mereka. Kesimpulannya, banyak responden yang tidak memiliki pengetahuan dan keterampilan yang memadai dalam mengelola urusan keuangannya.Kata Kunci: masalah keuangan, pinjaman, status tempat tinggal, pengeluaran impulsif, pengelolaan uang
Marginal Part-Time Employment in Indonesian Labor Market: Profile and Determinant
Authors: Mahmuda Dede
Published: November 2020

Abstract: The increase of marginal part-time employment has been found in developed countries, as well as in developing countries. This form of non-standard employment has very short work hours (less than 15 hours/week) and no guarantee of stable employment. In Indonesia, the share of part-time worker amongst working population increased from 15.4 percent in 2009 to 22.1 percent in 2018. Unfortunately, few studies discuss about marginal part-time employment. Using binary logistic regression, this study aims to identify marginal part-time workers based on their socio-demographic characteristic. The result indicates that female (OR: 1.81; 95% CI: 1.75-1.87), living in rural area (OR: 1.12; 95% CI: 1.08-1.16), and less educated are more likely to be marginal part-timer. Therefore, it is recommended for policymakers to ensure the labor regulation adequately protect the rights of part-time worker, so that the workers condition can be improved since they are most vulnerable group in the globalized economy.Keywords: non-standard employment, labor market, part-time, Indonesia Pekerja Paruh Waktu Marjinal Pada Pasar Tenaga Kerja Indonesia: Profil dan DeterminanAbstrak: Peningkatan pekerja paruh waktu marjinal telah teramati pada negara-negara maju dan juga negara berkembang. Salah satu bentuk pekerjaan non-standar ini memiliki jam kerja yang sangat pendek (kurang dari 15 jam seminggu) dan tidak adanya jaminan kestabilan pekerjaan. Di Indonesia, proporsi pekerja paruh waktu diantara penduduk bekerja meningkat dari 15,4 persen pada 2009 menjadi 22,1 persen pada 2018. Sayangnya, hanya sedikit studi yang membahas tentang pekerjaan paruh waktu marjinal. Dengan menggunakan regresi logistik biner, studi ini bertujuan untuk mengidentifikasi pekerja paruh waktu marjinal berdasarkan karakteristik sosio-demografinya. Hasil menunjukkan bahwa perempuan (OR: 1,81; 95% CI: 1,75-1,87), penduduk desa (OR: 1,12; 95% CI: 1,08-1,16), dan kurang berpendidikan berisiko lebih besar menjadi pekerja paruh waktu marjinal. Oleh karena itu, direkomendasikan bagi pembuat kebijakan untuk dapat memastikan peraturan ketenagakerjaan cukup untuk melindungi hak-hak pekerja paruh waktu khusus yang termarjinal agar kondisi pekerja dapat ditingkatkan karena mereka adalah kelompok paling rentan dalam ekonomi global.Kata kunci: pekerjaan non-standar, pasar tenaga kerja, paruh waktu, Indonesia
Consultor Jurídico do D.A.S.P
Authors: ENAP RSP
Published: November 2020

A Divisão do Pessoal Civil do Ministério da Guerra consulta se, tendo o art. 80, n.° IV, do Estatuto, se referido ao cômputo dotempo de serviço em autarquia apenas p efeito de disponibilidade e aposentadoria, poderia o art. 26 do Decreto n.° 32.015, de 29.de dezembro de 1952, autorizar a sua contagem para desempate na classificação por an tiguidade.
A Lei de Licença Prévia e o Mandado de Segurança
Authors: Wald Arnold
Published: November 2020

A nova lei de licença prévia, procurando coibir os abusos que vinham desfalcando o Tesouro Nacional e perturbando a política anti-inflacionista do govêrno, estabeleceu que os mandados de segurança relativos à entrada de bagagens no território nacional só poderiam ser executados depois do julgamento de tribunal de segunda instância a menos que seja oferecida caução idôneacorrespondente a 150% do valor das referidas bagagens.
Gobernanza de la pandemia covid-19 y modelos de gestión
Authors: Vidal Josep Pont
Published: November 2020

La pandemia causada por el covid-19 ha impulsado, de manera urgente y no planificada,  diferentes orientaciones o modelos de gobernanza de la pandemia. Los gobiernos han propuesto diferentes modelos u orientaciones de combate a la pandemia, con resultados no concluyentes. Estos modelos y las premisas que los subyacen, no son solo respuestas rápidas a una situación contingente e hipercompleja para dar respuesta a la situación sanitaria, sino que corresponden a la existencia de racionalidades, decisiones y planificación de modelos de Administración y gestión y su vínculo con el Estado. A partir de un contexto de hipercomplejidad, describimos una aproximación a los modelos de gestión de la pandemia de Suecia, Alemania y España principalmente. En base a las reflexiones sobre su gestión, abrimos un análisis sobre las orientaciones en la reconfiguración futura del Estado y su relación con la sociedad y la Administración y gestión pública y los impactos políticos ya visibles.
O teletrabalho como indutor de aumentos de produtividade e da racionalização de custos: uma aplicação empírica no Ministério da Justiça e Segurança Pública
Authors: Nogueira Filho José de Albuquerque , Oliveira Míriam Aparecida Mesquita , Sämy Fabiano Pereira Corrêa , Nunes André
Published: November 2020

O objetivo deste artigo é avaliar a implementação do teletrabalho no âmbito do Ministério da Justiça e Segurança Pública, com relação à redução de custos e ao aumento da produtividade. A literatura especializada apresenta benefícios para organizações e teletrabalhadores, relacionando-os à elevação da produtividade e à racionalização de custos, bem como à satisfação do teletrabalhador. Os dados analisados provêm de avaliações realizadas pelo Comitê Gestor do órgão no período de 01/09/2016 a 31/08/2017. Os resultados preliminares indicam que o teletrabalho contribui: na otimização de uso dos espaços físicos, possibilitando racionalização dos custos comuns da instituição; no aumento significativo da produtividade média dos servidores em teletrabalho. Logo, percebe-se que os resultados desta pesquisa corroboram os achados na literatura, sobretudo naquilo que se refere aos benefícios percebidos pela organização, visto que a adoção do teletrabalho evidenciou a elevação da produtividade e possibilidades reais de racionalização de custos no referido ministério.
Parlamento de saberes: a atuação de cientistas sociais nos debates na Câmara dos Deputados como uma forma de serviço público
Authors: Barros Antonio Teixeira de
Published: November 2020

Partindo da noção de intelectuais do campo das Ciências Sociais como intérpretes do mundo social e da política, o artigo tem como foco analítico a participação de cientistas sociais em debates políticos promovidos pela Câmara dos Deputados por meio das audiências públicas. O enfoque teórico adotado é o da Sociologia Política. Os debates são entendidos aqui como uma forma de serviço público prestado pelos pesquisadores convidados, a partir do compartilhamento de conhecimentos especializados no âmbito da agenda legislativa. As audiências públicas constituem um importante instrumento de trocas argumentativas e fontes de informação para subsidiar as decisões dos parlamentares. Para tanto, foram entrevistados antropólogos, cientistas políticos e sociólogos que participaram de debates no contexto legislativo ou que acompanham tais discussões. As conclusões indicam um olhar crítico desses atores, focado em duas abordagens: (a) os impactos e efeitos positivos do uso da expertise intelectual no campo político; e (b) nas suas limitações, devido à superficialidade e uso instrumental dos debates, principalmente no caso das audiências públicas.
Simulação de Monte Carlo para estimativa do tempo ótimo de contratos de concessão: Estudo de caso baseado em rodovias do Rio Grande do Sul
Authors: Nobre Fernandez Rodrigo , Pivatto Douglas , Freitas Everton , Carraro André , Bezerra dos Santos Helton Saulo
Published: November 2020

Este trabalho tem por objetivo analisar os contratos de concessão de praças de pedágio existentes no Estado do Rio Grande do Sul no período de 1998 até 2012, utilizando as informações obtidas do Relatório de Acompanhamento do Programa Estadual de Concessão Rodoviária do Rio Grande do Sul (PECR-RS). Para atingir tal meta, emprega-se o modelo de simulação proposto por Ng et al. (2007), o qual utiliza o procedimento de simulação de Monte Carlo, que permite inserir as informações contratuais, de modo a visualizar um possível comportamento das empresas durante a execução dos mesmos. Em suma, os resultados encontrados indicam que, para as praças analisadas com a taxa interna de retorno sendo aquela considerada no projeto básico de exploração, o tempo ótimo simulado foi igual ou menor do que aquele acordado contratualmente. Deve-se destacar que os contratos apresentados pelas concessionárias Rodo Sul e Santa Cruz seriam economicamente inviáveis dentro deste período de tempo.
Comunicação entre deputados federais brasileiros e cidadãos: há responsividade no contato por e-mail?
Authors: Franklin Luíza Amália Soares , Ferreira Marco Aurélio Marques , Campos Ana Paula Teixeira
Published: November 2020

Este trabalho buscou investigar o grau de responsividade dos deputados federais brasileiros quando contatados, por um cidadão, por meio eletrônico. Considerando as oportunidades de interação possibilitadas pelas tecnologias da comunicação e informação (TICs) e o dever da administração pública de um Estado democrático de dialogar com a população, verificou-se a importância de avaliar como os representantes do povo têm respondido ao contato realizado por um cidadão. Para tanto, foram realizados dois experimentos que consistiram no envio de e-mails para deputados federais, e as respostas foram analisadas com base em critérios advindos do conceito de “responsividade” – princípio chave da democracia. Foram enviados três e-mails para cada parlamentar, mas o índice de resposta foi de apenas 11,16%, número muito inferior ao obtido em outros estudos que aplicaram metodologia semelhante. No quesito qualidade das respostas, obteve-se notas regulares. Dessa forma, levando-se em conta o objeto de pesquisa aqui tratado, ou seja, os e-mails oficiais das deputadas e deputados, conclui-se que os parlamentares e seus assessores ainda apresentam um grande déficit quanto ao cumprimento do papel de informar e dialogar com os cidadãos. Assim, o uso de recursos tecnológicos oficiais na intermediação da relação entre parlamentares e população parece muito longe de atingir um caráter efetivamente democrático.
As recomendações e as soluções amistosas da Comissão Interamericana de Direitos Humanos: política, preferências e cumprimento
Authors: Sousa Costa Adriano , Roriz João
Published: November 2020

O artigo trata das recomendações e das soluções amistosas da Comissão Interamericana de Direitos Humanos e das respostas dos Estados a partir de uma ferramenta de avaliação de políticas públicas. Pressupondo a necessidade de problematizar o envolvimento da linguagem dos direitos humanos com os estudos de políticas públicas, o objetivo principal do texto é analisar as decisões da Comissão e a reação dos Estados a partir de preferências distintas dos atores envolvidos. O artigo considera as recomendações e soluções amistosas da Comissão não como um bloco monolítico sem distinções, mas como tipos variados que demandam políticas públicas diversas. Através da análise do relatório de 2017 da Comissão, em particular as suas ferramentas e o seu cumprimento por parte dos Estados, pode-se constatar que: (i) a Comissão Interamericana tem preferência por determinados tipos de ferramentas nos desenhos de soluções, (ii) os Estados também têm preferências por certos tipos de ferramentas, e (iii) tais preferências não coincidem com as da Comissão.