bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk factors for COVID-19-related death, hospitalization and intensive care: a population-wide study of all inhabitants in Stockholm
Authors: Hergens Maria-Pia , Bell Max , Haglund Per , Sundström Johan , Lampa Erik , Nederby-Öhd Joanna , Östlund Maria Rotzén , Cars Thomas
Published: January 2022

Since the beginning of the Covid-19 pandemic, the scientific community has explored determinants of Covid 19 disease severity. However, the majority of studies are based on in-hospital patients with high risk of collider- or selection bias. The present investigation details risk factors associated with overall mortality, hospitalization and intensive care unit (ICU) admission in Covid-19 infections, with complete population coverage and high-resolution data on patient characteristics and comorbid conditions This population-based observational study comprises all residents 18 years and older in Stockholm Region—1.8 million inhabitants—using the real-time Covid-19 monitoring framework. The observation period lasted between March 1 to December 31, 2020. Hazard ratios (HR) for risk factors of Covid-19 disease severity were assessed using Cox proportional hazard models. In total, 3322 deaths, 11,508 hospitalizations and 1423 ICU-admissions related to Covid-19 occurred during the study period. Kidney failure, diabetes and obesity increased risk of mortality and so did heart failure and ischemic heart disease. However, atrial fibrillation and hypertension did not. Risk of hospitalization follow a similar pattern, whereas admission to intensive care differs; triage processes where clearly present as certain co-morbid conditions were associated with lower ICU admission. Observed differences in risk of mortality and hospitalization among patients with Covid 19 raise important questions about potentially protective comedication which will be further addressed using the real-time Covid-19 monitoring framework.
Healthy lifestyle in older adults and life expectancy with and without heart failure
Authors: Limpens Marlou A. M. , Asllanaj Eralda , Dommershuijsen Lisanne J. , Boersma Eric , Ikram M. Arfan , Kavousi Maryam , Voortman Trudy
Published: January 2022

Several lifestyle factors have been linked to risk for heart failure (HF) and premature mortality. The aim of this study was to estimate the impact of a healthy lifestyle on life expectancy with and without HF among men and women from a general population. This study was performed among 6113 participants (mean age 65.8 ± 9.7 years; 58.9% women) from the Rotterdam Study, a large prospective population-based cohort study. A continuous lifestyle score was created based on five lifestyle factors: smoking status, alcohol consumption, diet quality, physical activity and weight status (assessed 1995–2008). The lifestyle score was categorized into three levels: unhealthy (reference), intermediate and healthy. Gompertz regression and multistate life tables were used to estimate the effects of lifestyle on life expectancy with and without HF in men and women separately at ages 45, 65 and 85 years (follow-up until 2016). During an average follow-up of 11.3 years, 699 incident HF events and 2146 deaths occurred. At the age of 45 years, men in the healthy lifestyle category had a 4.4 (95% CI: 4.1–4.7) years longer total life expectancy than men in the unhealthy lifestyle category, and a 4.8 (95% CI: 4.4–5.1) years longer life expectancy free of HF. Among women, the difference in total life-expectancy at the age of 45 years was 3.4 (95% CI: 3.2–3.5) years and was 3.4 (95% CI: 3.3–3.6) years longer for life expectancy without HF. This effect persisted also at older ages. An overall healthy lifestyle can have a positive impact on total life expectancy and life expectancy free of HF.
A Rod Theory for Liquid Crystalline Elastomers
Authors: Goriely Alain , Moulton Derek E. , Angela Mihai L.
Published: January 2022

We derive a general constitutive model for nematic liquid crystalline rods. Our approach consists in reducing the three-dimensional strain-energy density of a nematic cylindrical structure to a one-dimensional energy of a nematic rod. The reduced one-dimensional model connects directly the optothermal stimulation to the generation of intrinsic curvature, extension, torsion, and twist, and is applicable to a wide range of liquid crystalline rods subject to external stimuli and mechanical loads. For illustration, we obtain the shape of a clamped rod under uniform illumination, and compute the instability of an illuminated rod under tensile load. This general framework can be used to determine the shape and instabilities of nematic rods with different cross-sections or different alignment of the nematic field.
Study on Acoustic Emission Characteristics of Different Felsic Metagabbros Under Hydraulic Coupling
Authors: Zhang Tongzhao , Ji Hongguang , Su Xiaobo , Quan Daolu , Zhang Zhou , Li Jinzhe
Published: January 2022

The mechanical properties of the deep rock are impacted not only by the complicated stress environment but also by the mineral composition. To reveal the relationship between mineral development characteristics and acoustic emission signals in the mechanical evolution of deep rocks, metagabbros with different feldspar mineral development were subjected to acoustic emission tests under hydraulic coupling. The characteristic parameter of acoustic emission signals and their correlation characteristics were investigated. The results showed that the mechanical property of the metagabbro with feldspar mineral development was better than that without feldspar mineral. The metagabbro with feldspar mineral development had much larger AE ringing counts and absolute energies, as well as stronger rock brittleness features than that without feldspar mineral development. With increasing feldspar mineral content in metagabbro, the AE signals showed a longer duration and a higher amplitude. During the unstable crack propagation stage, metagabbro without feldspar mineral development exhibited four peak frequency ranges, while that with feldspar mineral development displayed five frequency ranges. The metagabbro with nonuniform feldspar mineral development had more pores and microcracks than that with uniform mineral development. The permeability of the rocks was highly correlated with the uniformity of mineral development. This study provides a theoretical foundation for monitoring and early warning of water inrush risk in deep rock engineering.
Depressive symptoms improve over 2 years of type 2 diabetes treatment via a digital continuous remote care intervention focused on carbohydrate restriction
Authors: Adams Rebecca N. , Athinarayanan Shaminie J. , McKenzie Amy L. , Hallberg Sarah J. , McCarter James P. , Phinney Stephen D. , Gonzalez Jeffrey S.
Published: January 2022

Depressive symptoms are prevalent among people with type 2 diabetes (T2D) and, even at low severity levels, are associated with worse diabetes outcomes. Carbohydrate restriction is an effective treatment for T2D but its long-term impacts on depressive symptoms are unclear. In the current study we explored changes in depressive symptoms over 2 years among 262 primarily non-depressed T2D patients participating in a continuous remote care intervention emphasizing carbohydrate restriction. Subclinical depressive symptoms decreased over the first 10 weeks and reductions were maintained out to 2 years. Increased frequency of blood ketone levels indicative of adherence to low carbohydrate eating predicted decreases in depressive symptoms. Concerns have been raised with recommending restrictive diets due to potential negative impacts on quality-of-life factors such as mood; however, results of the current study support positive rather than negative long-term impacts of closely monitored carbohydrate restriction on depressive symptoms.
Collaborative Inquiry with Men Who Use Intimate Partner Violence: Service User Perspectives on Expertise in Domestic Violence Services for Men
Authors: Jury Rebecca
Published: January 2022

Concerns have been expressed regarding the efficacy of services for heterosexual men who use intimate partner violence. In addition, there has been limited research into the perspectives of these men regarding their use of services. The Australian study outlined in this article sought to examine the experiences of heterosexual men who use intimate partner violence (IPV) when they access domestic violence services. Collaborative inquiry was undertaken with men who were attending a residential domestic violence service to explore the research question; What does expertise look like in domestic violence services for men? When discussing expertise, twenty men identified four themes: lived experience and book knowledge, services and supports, professional helping skills and expertise, and non-professional helping and expertise. These collaborative researchers described expertise as a product of book knowledge and lived experience knowledge, indicating these knowledges could be located within the one person or shared between professionals and service attendees. The informants suggested cultural mentoring, peer support and co-production are important inclusions in men’s domestic violence services. They also highlighted positive peer affirmations as supporting their behaviour change and suggested sociological frameworks are central to successful interventions with men. Men who use IPV may have important insights about expertise in domestic violence services for men which can inform future practice.
Switching Interacting Particle Systems: Scaling Limits, Uphill Diffusion and Boundary Layer
Authors: Floreani Simone , Giardinà Cristian , Hollander Frank den , Nandan Shubhamoy , Redig Frank
Published: January 2022

This paper considers three classes of interacting particle systems on $${{\mathbb {Z}}}$$
Z
: independent random walks, the exclusion process, and the inclusion process. Particles are allowed to switch their jump rate (the rate identifies the type of particle) between 1 (fast particles) and $$\epsilon \in [0,1]$$

ϵ
∈
[
0
,
1
]

(slow particles). The switch between the two jump rates happens at rate $$\gamma \in (0,\infty )$$

γ
∈
(
0
,
∞
)

. In the exclusion process, the interaction is such that each site can be occupied by at most one particle of each type. In the inclusion process, the interaction takes places between particles of the same type at different sites and between particles of different type at the same site. We derive the macroscopic limit equations for the three systems, obtained after scaling space by $$N^{-1}$$

N

-
1

, time by $$N^2$$

N
2

, the switching rate by $$N^{-2}$$

N

-
2

, and letting $$N\rightarrow \infty $$

N
→
∞

. The limit equations for the macroscopic densities associated to the fast and slow particles is the well-studied double diffusivity model. This system of reaction-diffusion equations was introduced to model polycrystal diffusion and dislocation pipe diffusion, with the goal to overcome the limitations imposed by Fick’s law. In order to investigate the microscopic out-of-equilibrium properties, we analyse the system on $$[N]=\{1,\ldots ,N\}$$

[
N
]
=
{
1
,
…
,
N
}

, adding boundary reservoirs at sites 1 and N of fast and slow particles, respectively. Inside [N] particles move as before, but now particles are injected and absorbed at sites 1 and N with prescribed rates that depend on the particle type. We compute the steady-state density profile and the steady-state current. It turns out that uphill diffusion is possible, i.e., the total flow can be in the direction of increasing total density. This phenomenon, which cannot occur in a single-type particle system, is a violation of Fick’s law made possible by the switching between types. We rescale the microscopic steady-state density profile and steady-state current and obtain the steady-state solution of a boundary-value problem for the double diffusivity model.
Rubiscosome gene expression is balanced across the hexaploid wheat genome
Authors: Caruana Louis , Orr Douglas J. , Carmo-Silva Elizabete
Published: January 2022

Functional and active Rubisco is essential for CO2 fixation and is a primary target for engineering approaches to increasing crop yields. However, the assembly and maintenance of active Rubisco are dependent on the coordinated biosynthesis of at least 11 nuclear-encoded proteins, termed the ‘Rubiscosome’. Using publicly available gene expression data for wheat (Triticum aestivum L.), we show that the expression of Rubiscosome genes is balanced across the three closely related subgenomes that form the allohexaploid genome. Each subgenome contains a near complete set of homoeologous genes and contributes equally to overall expression, both under optimal and under heat stress conditions. The expression of the wheat thermo-tolerant Rubisco activase isoform 1β increases under heat stress and remains balanced across the subgenomes, albeit with a slight shift towards greater contribution from the D subgenome. The findings show that the gene copies in all three subgenomes need to be accounted for when designing strategies for crop improvement.
Impact of postanesthesia care unit delirium on self-reported cognitive function and perceived health status: a prospective observational cohort study
Authors: Kainz Elena , Stuff Karin , Kahl Ursula , Wiessner Christian , Yu Yuanyuan , von Breunig Franziska , Nitzschke Rainer , Haese Alexander , Graefen Markus , Fischer Marlene
Published: January 2022

Purpose

The objective of this study was to determine the influence of postanesthesia care unit (PACU) delirium on self-reported cognitive function and perceived health status 3 months after surgery.

Methods

This prospective observational cohort study was performed in a PACU at a high-volume prostate cancer center. We used a convenience sample of patients > 60 years undergoing elective radical prostatectomy. Patients with a history of cerebrovascular or neurodegenerative disease were excluded. Fifteen, 30, 45, and 60 following extubation, patients were screened for signs of delirium with the Confusion Assessment Method for the Intensive Care Unit. Three months after surgery self-reported cognitive function was assessed with the Cognitive Failures Questionnaire, and health status was evaluated with the 36-item Short-Form Health Survey (SF-36).

Results

Signs of PACU delirium were present in 32.4% (n = 72/222) of patients, and 80.2% (n = 178/222) completed the 3-month follow-up. The presence of PACU delirium signs was not significantly associated with self-reported cognitive failures (B = 0.60, 95% CI: −1.72; 2.92, p = 0.61) or SF-36 physical component scores (B = 0.19, 95% CI: 0.02; 0.36, p = 0.03) or SF-36 mental component scores (B =  −0.03, 95% CI: −0.18, 0.11, p = 0.66) 3 months after radical prostatectomy.

Conclusions

In a cohort of educated, highly functioning, elderly male patients who were assessed immediately after surgery and at a 3-month follow-up, we found no association between PACU delirium and self-reported cognitive failures or perceived health status, which implies that PACU delirium may be an event of limited duration and impact.

Trial registration

The study was registered at ClinicalTrials.gov (Identifier: NCT04168268, Date of registration: November 19, 2019).
Business-as-usual reading instruction in 2nd grade: teacher centered and rarely evidence-based
Authors: Peters Martin T. , Förster Natalie , Forthmann Boris , Souvignier Elmar
Published: January 2022

The goal of the current study was to gain insight into what elements encompass business-as-usual (BAU) reading instruction and to what extent BAU reading instruction includes elements that have been found to positively impact reading competence. In addition, we examined whether and how these evidence-based elements are incorporated and how they cluster. In total, in 52 2nd grade classrooms from 30 schools, reading instruction was systematically observed by a trained student assistant. In 24 of these classrooms, a second co-observer rated the lesson to assess inter-rater reliability. In addition, teachers were asked about content-related aspects of their reading instruction using a questionnaire. The observations showed that BAU reading instruction was predominantly teacher centered and characterized by many phases in which students worked independently. Evidence-based elements of reading instruction were rarely observed. Further, teachers rated their instruction as more differentiated than did observers. Our cluster analysis of evidence-based elements of reading instruction revealed that in BAU reading instruction, various aspects of strategy instruction are primarily implemented together.
Impact of Covid-19 on research output by gender across countries
Authors: Abramo Giovanni , D’Angelo Ciriaco Andrea , Mele Ida
Published: January 2022

The massive shock of the COVID-19 pandemic has already shown its negative effects on economies around the world, unprecedented in recent history. COVID-19 infections and containment measures caused a general slowdown in research and new knowledge production. Because of the link between R&D output and economic growth, it is to be expected then that a slowdown in research activities will slow in turn the global recovery from the pandemic. Many recent studies also claim an uneven impact on scientific production across gender. In this paper, we investigate the phenomenon across countries, analysing preprint depositions in main repositories. Differently from other works, that compare the number of preprint depositions before and after the pandemic outbreak, we analyse the depositions trends across geographical areas, and contrast after-pandemic outbreak depositions with expected ones. Differently from common belief and initial evidence, the decrease in research output is not more severe for women than for men.
National and organizational patterns of Nobel laureate careers in physiology/medicine, physics, and chemistry
Authors: Heinze Thomas , Fuchs Joel Emanuel
Published: January 2022

This paper examines the distribution of Nobel laureates in Physiology/Medicine, Physics, and Chemistry across countries and research organizations. We provide basic information about where future laureates received their education and/or conducted their research, then present heat maps depicting country and organizational specialization patterns. In addition, we identify theorganizational ultra-elitein science: universities and research institutes that show continuously above-average numbers of future laureates, typically in one career phase. Furthermore, we identify those universities and research institutes that have undergone considerable growth (or decline) in their capabilities for highly innovative research. Also, we compare country-specific profiles with those at the organizational level. Our findings are interpreted in the light of findings from comparative-historical studies.
Catalytic Production of Renewable Hydrogen for Use in Fuel Cells: A Review Study
Authors: Rossetti Ilenia , Tripodi Antonio
Published: January 2022

Hydrogen production from renewable sources is gaining increasing importance for application as fuel, in particular with high efficiency and low impact devices such as fuel cells. In addition, the possibility to produce more sustainable hydrogen for industrial application is also of interest for fundamental industrial processes, such as ammonia and methanol synthesis. Catalytic processes are used in most options for the production of hydrogen from renewable sources. Catalysts are directly involved in the main transformation, as in the case of reforming and of electro-/photo-catalytic water splitting, or in the upgrade and refining of the main reaction products, as in the case of tar reforming. In every case, for the main processes that reached a sufficiently mature development stage, attempts of process design, economic and environmental impact assessment are presented, on one hand to finalise the demonstration of the technology, on the other hand to highlight the challenges and bottlenecks. Selected examples are described, highlighting whenever possible the role of catalysis and the open issues, e.g. for the H2 production from reforming, aqueous phase reforming, biomass pyrolysis and gasification, photo- and electro-catalytic processes, enzymatic catalysis. The case history of hydrogen production from bioethanol for use in fuel cells is detailed from the point of view of process design and techno-economic validation. Examples of steady state or dynamic simulation of a centralised or distributed H2 production unit are presented to demonstrate the feasibility of this technology, that appears as one of the nearest to market. The economic feasibility seems demonstrated when producing hydrogen starting from diluted bioethanol.
Kidney failure, CKD progression and mortality after nephrectomy
Authors: Ellis Robert J. , Cameron Anne , Gobe Glenda C. , Diwan Vishal , Healy Helen G. , Lee Jeremy , Tan Ken-Soon , Venuthurupalli Sree , Zhang Jianzhen , Hoy Wendy E. ,   the NHMRC CKD.CRE, the CKD.QLD Collaborative
Published: January 2022

Purpose

This study tested the hypothesis that progression of chronic kidney disease (CKD) is less aggressive in patients whose primary cause of CKD was nephrectomy, compared with non-surgical causes.

Methods

A sample of 5983 patients from five specialist nephrology practices was ascertained from the Queensland CKD Registry. Rates of kidney failure/death were compared on primary aetiology of CKD using multivariable Cox proportional hazards models. CKD progression was compared using multivariable linear and logistic regression analyses.

Results

Of 235 patients with an acquired single kidney as their primary cause of CKD, 24 (10%) and 38 (17%) developed kidney failure or died at median [IQR] follow-up times of 12.9 [2.5–31.0] and 33.6 [18.0–57.9] months after recruitment. Among patients with an eGFR < 45 mL/min per 1.73m2 at recruitment, patients with diabetic nephropathy and PCKD had the highest rates (per 1000 person-years) of kidney failure (107.8, 95% CI 71.0–163.8; 75.5, 95% CI 65.6–87.1); whereas, patients with glomerulonephritis and an acquired single kidney had lower rates (52.9, 95% CI 38.8–72.1; 34.6, 95% CI 20.5–58.4, respectively). Among patients with an eGFR ≥ 45 mL/min per 1.73m2, those with diabetic nephropathy had the highest rates of kidney failure (16.6, 95% CI 92.5–117.3); whereas, those with glomerulonephritis, PCKD and acquired single kidney had a lower risk (11.3, 95% CI 7.1–17.9; 11.7, 95% CI 3.8–36.2; 10.7, 95% CI 4.0–28.4, respectively).

Conclusion

Patients who developed CKD after nephrectomy had similar rates of adverse events to most other causes of CKD, except for diabetic nephropathy which was consistently associated with worse outcomes. While CKD after nephrectomy is not the most aggressive cause of kidney disease, it is by no means benign, and is associated with a tangible risk of kidney failure and death, which is comparable to other major causes of CKD.
The Value of Strident Agnosticism: Dorothy Pawluch and the Endurance of Ontological Gerrymandering
Authors: Woolgar Steve
Published: January 2022

This paper reflects on the origins and subsequent reception of the paper “Ontological Gerrymandering: The anatomy of social problems explanations”, published in 1985. It describes the circumstances of my turning up at McGill University as a Visiting Professor in Sociology and meeting Dorothy, then a graduate student and the TA assigned to an undergraduate course on Social Problems which I was asked to teach. The paper reflects on the twin benefits: of an interloper, from Europe and from Science and Technology Studies (STS), entering the exotic and heady fray of North American social problems; and of Dorothy’s steady and resolute guidance in introducing me to a new field. The paper suggests some reasons for the endurance of the paper’s arguments, more than 35 years after its publication, drawing on some parallel developments in Social Problems and STS. It asks why has there been rather little mutual interaction between these disciplines, given their common concern with questions, among others, about values, effects and interventions in academic scholarship. The paper concludes that many more of us might have done well to pursue the path of strident agnosticism.
Metabolic and electrolyte abnormalities as risk factors in drug-induced long QT syndrome
Authors: TeBay Clifford , Hill Adam P. , Windley Monique J.
Published: January 2022

Drug-induced long QT syndrome (diLQTS) is the phenomenon by which the administration of drugs causes prolongation of cardiac repolarisation and leads to an increased risk of the ventricular tachycardia known as torsades de pointes (TdP). In most cases of diLQTS, the primary molecular target is the human ether-à-go-go-related gene protein (hERG) potassium channel, which carries the rapid delayed rectifier current (IKr) in the heart. However, the proarrhythmic risk associated with drugs that block hERG can be modified in patients by a range of environmental- and disease-related factors, such as febrile temperatures, alterations in pH, dyselectrolytaemias such as hypokalaemia and hypomagnesemia and coadministration with other drugs. In this review, we will discuss the clinical occurrence of drug-induced LQTS in the context of these modifying factors as well as the mechanisms by which they contribute to altered hERG potency and proarrhythmic risk.
Antioxidant-containing monoolein aqueous dispersions: a preliminary study
Authors: Sguizzato Maddalena , Drechsler Markus , Baldisserotto Anna , Cortesi Rita , Esposito Elisabetta
Published: January 2022

The present study describes a preliminary study on the use of monoolein aqueous dispersions (MADs) as delivery systems for antioxidant molecules, namely, ascorbyl palmitate (AP) and alpha-tocopherol (AT). MAD, produced by emulsifying monoolein (4.5% w/w) in water and poloxamer 407 (0.5% w/w) as emulsifier, was characterized in terms of size, morphology, and antioxidant activity by mean of PCS, cryo-TEM, and (2,2-diphenyl-1-picrylhydrazyl) assay. MAD-AP or MAD-AT gave rise to a bimodal size distribution with mean size around 200 nm. All the preparations stored at 25 °C showed quite stable size at least up to 90 days. Cryo-TEM images confirmed MAD size distribution and indicated different MAD morphologies as a function of the loaded antioxidant molecule. Indeed, in the case of MAD-AP, vesicles and cubosomes with the typical inner cubic structure were observed, while vesicles and hexosomes were shown for MAD-AT. The encapsulation efficiency of both antioxidants reached more than 90% with respect to the total amount of drug used for MAD preparation. Moreover, AP and AT antioxidant activity was retained after encapsulation, and in vitro Franz cell experiments showed that the MAD enabled to better control the drug release. These preliminary results suggest that MAD formulations could be further investigated as a potential delivery system for antioxidant supplementation in dietary or cosmetic fields.

Graphical abstract
Genome-wide identification and characterization of grapevine UFD1 genes during berry development and salt stress response
Authors: Wei Lingzhu , Cheng Jianhui , Xiang Jiang , Wu Jiang
Published: January 2022

Grapevine (Vitis vinifera) is widely applicated in food industry, which shows high economical and nutritional values. However, growth of grapevine was usually affected by various environmental stresses, such as salt, drought and disease. Ubiquitin fusion degradation protein 1 (UFD1) is an essential ubiquitin-recognition protein facilitates regulation of stress response through ERAD pathway. Even though, a comprehensive investigation of UFD1 genes in the plant species is still lacking. Here we identified three VvUFD1 proteins from genome of grapevine, which were assigned into different subgroups. All VvUFD1 genes contain highly conserved motifs in structure. Several cis-elements that related to fruit development and stress response were found in the promoter regions of VvUFD1 genes, including bHLH, NCA, MYB, HD-ZIP, GATA and AP2. Expression analysis found VvUFD1 genes showed different expression patterns in different tissues. Most importantly, VvUFD1 genes were found to be involved in salt stress response during growth of grapevine. Transcriptomic analyses were investigated for further understanding the genes’ function. Expression of VvUFD1 were increased at late stage of berry ripening. In addition, expression of VvUFD1 were also regulated by elevated light treatment and pathogen Neofusicoccum parvum infection. Co-expression network analysis revealed several major transcription factors that co-expressed with VvUFD1 genes. These results provide a basis for investigating the function of UFD1 genes in plant species and expand understanding of the regulation of berry development and salt stress response in grapevine.
Auslandsdeutsche Mediendiskurse: sprachliche und interkulturelle Aspekte von Minderheitenzeitungen
Authors: Földes Csaba
Published: January 2022

Der Aufsatz behandelt einen in der Medienlinguistik noch weitgehend unerforschten Zeitungstyp: die Presse deutsch(sprachig)er Minderheiten im Ausland. Im Sinne eines Werkstattberichts fasst der Beitrag das Untersuchungsdesign, die zentralen Inhaltsstrukturen bzw. -elemente sowie die bisherigen Beobachtungen und Ergebnisse eines aktuellen Forschungsprojekts mit Überblickscharakter zusammen und stellt sie zur Diskussion. Am Beispiel von drei Minderheitenzeitungen aus Russland, Kasachstan und Ungarn konnte die explorative Studie u. a. zu folgenden Befunden gelangen: (1) Aufgrund von Mehrsprachigkeit und Mehrschriftlichkeit bildet vor allem eine Bandbreite sprachkontaktinduzierter Phänomene das wichtigste Alleinstellungsmerkmal dieser Zeitungen. (2) Es liegen viele etwas eklektische und stilistisch-pragmatisch inkonsistente Texte vor. (3) Inhaltliche und kulturinduzierte Auffälligkeiten prägen das Gesamtbild des untersuchten medialen Mikrokosmos. (4) Die Kompetenzbesonderheiten der mehrsprachigen Textproduzenten färben auf die Textgestaltung ab.
SUMO E3 ligase SIZ1 negatively regulates arsenite resistance via depressing GSH biosynthesis in Arabidopsis
Authors: Hong Yechun , Chen Yunjuan , Shi Huazhong , Kong Xiangfeng , Yao Juanjuan , Lei Mingguang , Zhu Jian-Kang , Wang Zhen
Published: January 2022

Arsenic is a metalloid toxic to plants, animals and human beings. Small ubiquitin-like modifier (SUMO) conjugation is involved in many biological processes in plants. However, the role of SUMOylation in regulating plant arsenic response is still unclear. In this study, we found that dysfunction of SUMO E3 ligase SIZ1 improves arsenite resistance in Arabidopsis. Overexpression of the dominant-negative SUMO E2 variant resembled the arsenite-resistant phenotype of siz1 mutant, indicating that SUMOylation plays a negative role in plant arsenite detoxification. The siz1 mutant accumulated more glutathione (GSH) than the wild type under arsenite stress, and the arsenite-resistant phenotype of siz1 was depressed by inhibiting GSH biosynthesis. The transcript levels of the genes in the GSH biosynthetic pathway were increased in the siz1 mutant comparing with the wild type in response to arsenite treatment. Taken together, our findings revealed a novel function of SIZ1 in modulating plant arsenite response through regulating the GSH-dependent detoxification.
The Statistical Physics of Data Assimilation and Machine Learning
Authors: Abarbanel Henry D. I.
Published: January 2022

Data assimilation is a hugely important mathematical technique, relevant in fields as diverse as geophysics, data science, and neuroscience. This modern book provides an authoritative treatment of the field as it relates to several scientific disciplines, with a particular emphasis on recent developments from machine learning and its role in the optimisation of data assimilation. Underlying theory from statistical physics, such as path integrals and Monte Carlo methods, are developed in the text as a basis for data assimilation, and the author then explores examples from current multidisciplinary research such as the modelling of shallow water systems, ocean dynamics, and neuronal dynamics in the avian brain. The theory of data assimilation and machine learning is introduced in an accessible and unified manner, and the book is suitable for undergraduate and graduate students from science and engineering without specialized experience of statistical physics.
Teaching Publishing and Editorial Practice
Authors: Hargrave Jocelyn
Published: January 2022

A key challenge facing all educators working in practice-based subjects is the need to negotiate tensions between past and present and provide a training that prepares students for fast-changing conditions, while also conveying long-standing principles. This Element therefore investigates how effectively editing and publishing programmes prepare graduates for industry and how well these graduates translate this instruction to the workplace. Taking a global perspective to gauge the state of the discipline, the mixed-methods approach used for this Element comprised two online surveys for educators and graduates, three semi-structured interviews with industry practitioners (scholarly, education and trade) and ethnographic practice (author as educator and practitioner). Three key concepts also framed this Element's enquiry: being, learning and doing. The Element demonstrates how these transitioning but interdependent concepts have the potential to form a holistic practice-led pedagogy for students of editing and publishing programmes.
Can Arbitrary Beliefs be Rational?
Authors: Skipper Mattias
Published: January 2022

When a belief has been influenced, in part or whole, by factors that, by the believer's own lights, do not bear on the truth of the believed proposition, we can say that the belief has been, in a sense,arbitrarily formed. Can such beliefs ever be rational? It might seem obvious that they can't. After all, belief, supposedly, “aims at the truth.” But many epistemologists have come to think that certain kinds of arbitrary beliefs can, indeed, be rational. In this paper, I want to do two things. First, I want to show that the claim that arbitrary beliefs can be rational is inconsistent with the conjunction of two other attractive claims: one saying that rationality requires a certain kind ofepistemic immodesty, and one saying that rationality forbids certain kinds ofself-ascriptions of epistemic luck. Second, I want to evaluate different ways one might respond to this inconsistent triad. I won't defend any response in particular, but I'll draw out some notable costs and benefits of each response, which may help shed light on the question of whether arbitrary beliefs can be rational.
Can We Talk? The Application of the Public Law Democratic Dialogue Model to the Interactions between Domestic Legislatures and the European Courts
Authors: Gillis Matilda
Published: January 2022

The democratic dialogue model is a domestic constitutional model of rights protection, which is used to explain and evaluate the relationship between domestic courts and legislatures. It is characterised by there being some capacity on the part of the legislature to respond to a court decision and it claims, among other things, to produce a ‘better protection of human rights’. This paper examines whether the democratic dialogue model can be, and should be, applied to the relationship between state legislatures and, respectively, the European Court of Human Rights and the Court of Justice of the European Union (the European Courts). The paper first demonstrates that this proposed application of the model differs from other accounts of dialogue hitherto applied at the transnational level. It examines how exactly the model can be applied to the relationship between national legislatures and the European Courts and it demonstrates that the model provides an explanatory framework for the interactions between the institutions. It argues that the normative claims of the domestic dialogue model are achieved when the model is applied in the proposed way, but it acknowledges that the achievement of those normative claims might not always be desirable at the transnational level.
Resolved and subgrid-scale crossing trajectory effects in Eulerian large eddy simulations of size-dependent droplet transport
Authors: Aiyer A.K. , Meneveau C.
Published: January 2022

We study the dispersion characteristics of slightly buoyant droplets in a turbulent jet using large eddy simulations (LES). The droplet number density fields are represented using an Eulerian approach, with the dispersed phase modelled using the Fast-Eulerian method (Ferry & Balachandar, Intl J. Multiphase Flow, vol. 27, issue 7, pp. 1199–1226, 2001) that includes the droplet rise velocity. Radial concentration profiles and turbulent concentration fluxes for droplets of different sizes are analysed to quantify the ‘trajectory crossing effect’, when relative motions between particles and turbulent eddies tend to reduce turbulent diffusion. For finer LES grid resolutions, the model captures the differential, size-based dispersion characteristics of the droplets with the transverse dispersion of the larger droplet sizes suppressed, since trajectory crossing effects are explicitly resolved in LES. We examine a similarity solution model for the size-dependent radial concentration profiles based on a modified Schmidt number derived from the theory of turbulent diffusion of particles in the atmosphere proposed by Csanady (J. Atmos. Sci., vol. 20, pp. 201–208, 1963). The results are validated with the high resolution LES data and show good agreement. Then the size-dependent Schmidt number model is reformulated as a model for unresolved subgrid-scale trajectory crossing effects and used to calculate the subgrid concentration flux in a coarse LES of a turbulent jet, with slightly buoyant droplets injected at the centreline in the self-similar region of the jet. The results are compared to a simulation with higher grid resolution and a coarse simulation with a constant Schmidt number subgrid-scale model. We find that the subgrid model enhances the prediction accuracy of the concentration profiles and turbulent concentration flux for the coarse LES.
Counter-flow orbiting of the vortex centre in turbulent thermal convection
Authors: Li Yi-Zhen , Chen Xin , Xu Ao , Xi Heng-Dong
Published: January 2022

We present an experimental study of the large-scale vortex (or large-scale circulation, LSC) in turbulent Rayleigh–Bénard convection in a

$\varGamma =\text {diameter}/\text {height}=2$

cylindrical cell. The working fluid is deionized water with Prandtl number (

$Pr$

) around 5.7, and the Rayleigh number (

$Ra$

) ranges from

$7.64\times 10^7$

to

$6.06\times 10^8$

. We measured the velocity field in various vertical cross-sectional planes by using the planar particle image velocimetry technique. The velocity measurement in the LSC central plane shows that the flow is in the single-roll form, and the centre of the single-roll (vortex) does not always stay at the centre of the cell; instead, it orbits periodically in the direction opposite to the flow direction of the LSC, with its trajectory in the shape of an ellipse. The velocity measurements in the three vertical planes in parallel to the LSC central plane indicate that the flow is in the vortex tube form horizontally filling almost the whole cell, and the centre line of the vortex tube is consistent with the so-called ‘jump rope’ form proposed by a previous study that combined numerical simulation and local velocity measurements in the low

$Pr$

case (Vogt et al., Proc. Natl Acad. Sci. USA, vol. 115, 2018, pp. 12674–12679). In addition, we found that the oscillation of the local velocity in

$\varGamma =2$

cells originates from the periodical orbiting of the vortex centre. Our velocity measurements further indicate that the vortex centre orbiting is absent in

$\varGamma =1$

cells, at least in the

$Ra$

range of our experiments.
First evidence for Neoproterozoic rocks offshore South-East Greenland
Authors: Guarnieri Pierpaolo , Storey Michael , Thomsen Tonny B. , Heredia Benjamin Dominguez , Malkki Sebastian Næsby
Published: January 2022

Meta-sedimentary rocks recovered beneath Palaeogene basalts near the base of Ocean Drilling Program (ODP) Leg 152-917A offshore South-East Greenland were thought to be of Late Cretaceous age. This interpretation, however, has several inconsistencies as it requires a tectono-metamorphic event during the Cretaceous not recognized in the North Atlantic region, and the presence of a wide Mesozoic sedimentary basin that extended from SE-Greenland to the Rockall Plateau, for which there is currently no evidence. Here, we report a Neoproterozoic U/Pb apatite age of 905 ± 21 Ma and a younger40Ar/39Ar isochron whole-rock age of 820 ± 40 Ma for an altered tuff layer that occurs in the upper part of the meta-volcaniclastic sequence recovered from hole 917A. The40Ar/39Ar step-heating ages on biotite and whole-rock mini-cores from deeper in hole 917A yielded Palaeoproterozic dates that cluster around 1950 to 1850 Ma, pointing toward a Palaeoproterozoic source. The U/Pb apatite date is interpreted as the eruption age of the tuff layer, whereas the younger whole-rock40Ar/39Ar age is consistent with low-temperature greenschist alteration of volcanic glass and secondary mineral growth during sedimentary burial in an extensional regime. Thec.905 Ma age for the tuff provides the first evidence for Neoproterozoic rocks offshore South-East Greenland and suggests a correlation between this sequence and the Torridon Group in the Hebridean Foreland of the Scottish Caledonides. The calc-alkaline nature of the volcaniclastic rocks and the age of the tuff layer point toward a source area with arc-magmatism related to the Renlandian event of the Valhalla Orogeny.
The heritability of Nematodirus battus fecal egg counts
Authors: Nikbin Saeid , Almasi Fazel , Alenizi Dalal , Jenvey Caitlin , Sloan Sarah , Preston Sarah , Piedrafita David , Jonsson Nicholas , Stear Michael
Published: January 2022

Although Nematodirus battus is a serious threat to the health and survival of young lambs, there are few options to control this parasite. Bayesian Monte Carlo Markov Chain modelling with a zero-inflated Poisson distribution was used to estimate the heritability of egg counts in both June and July for each of five consecutive cohorts of 200 Scottish Blackface lambs. In one of the 10 analyses, the results failed the diagnostic tests. In seven of the analyses, there was no convincing evidence that the variation in egg counts was heritable. In the 2 years of high infection, the heritability was approximately 0.4 in June but the estimates lacked precision and the 95% highest posterior density credible intervals ranged from just above zero to 0.7. Selective breeding for resistance to N. battus will be difficult because genetically resistant or susceptible lambs cannot be consistently identified by phenotypic markers.
Three new species of Helicometroides Yamaguti, 1934 from Japan and Australia, with new molecular evidence of a widespread species
Authors: Wee Nicholas Q-X. , Cribb Thomas H. , Shirakashi Sho , Cutmore Scott C.
Published: January 2022

We report specimens of monorchiids infecting Haemulidae from the waters off Japan and Australia; these specimens represent five species of Helicometroides Yamaguti, 1934, three of which are unambiguously new. Helicometroides murakamii n. sp. infects Diagramma pictum pictum from off Minabe, Japan; Helicometroides gabrieli n. sp. infects Plectorhinchus chrysotaenia from off Lizard Island, Australia; and Helicometroides wardae n. sp. infects Plectorhinchus flavomaculatus and Plectorhinchus multivittatus from off Heron Island, Australia. Helicometroides murakamii n. sp. and H. gabrieli n. sp. conform to the most recent diagnosis of Helicometroides in lacking a terminal organ, but H. wardae n. sp. possesses a terminal organ with distinct, robust spines; despite this morphological distinction, the three form a strongly-supported clade in phylogenetic analyses. We also report specimens morphologically consistent with Helicometroides longicollis Yamaguti, 1934, from D. pictum pictum from off Minabe, Japan, and Diagramma pictum labiosum on the Great Barrier Reef, Australia. Genetic analyses of ITS2 rDNA, 28S rDNA and cox1 mtDNA sequence data for the Japanese specimens reveal the presence of two distinct genotypes. Specimens of the two genotypes were discovered in mixed infections and are morphologically indistinguishable; neither genotype can be associated definitively with H. longicollis as originally described. We thus identify them as H. longicollis lineage 1 and 2, pending study of further fresh material. Genetic analyses of specimens from the Great Barrier Reef are consistent with the presence of only H. longicollis lineage 1. This species thus has a range that incorporates at least Australia and Japan, localities separated by over 7000 km.
Ecological specificity explains infection parameters of anuran parasites at different scales
Authors: Euclydes Lorena , De La Torre Gabriel M. , Dudczak Amanda Caroline , Melo Francisco Tiago de Vasconcelos , Campião Karla Magalhães
Published: January 2022

Understanding the determinants of parasite infection in different hosts is one of the main goals of disease ecology. Evaluating the relationship between parasite–host specificity and infection parameters within host communities and populations may contribute to this understanding. Here we propose two measures of specificity that encompasses phylogenetic and ecological relatedness among hosts and investigated how such metrics explain parasite infection prevalence and mean infection intensity (MII). We analysed the parasites associated with an anuran community in an area of Atlantic Forest and used the number of infected hosts and the net relatedness index to calculate the phylogenetic and ecological specificities of the parasites. These specificity measures were related to infection metrics (prevalence and MII) with generalized linear mixed models at community (all hosts) and population (infected host species) scales. Parasite prevalence was correlated with the number of infected hosts and, when considering only multi-host parasites, was positively related to parasite ecological specificity at community and population scales. Thus, parasite species have similar prevalences in ecologically closer hosts. No relationship was found for parasite MII. Incorporating ecological characteristics of hosts in parasite specificity analyses improves the detection of patterns of specificity across scales.
Is adult separation anxiety associated with offspring risk for internalizing psychiatric problems?
Authors: Finsaas Megan C. , Klein Daniel N.
Published: January 2022

Background

Awareness of adult separation anxiety (ASA) is growing, but there is a dearth of knowledge about how separation anxiety aggregates in families. We examined the intergenerational associations of separation anxiety and other forms of internalizing problems in an American community sample of 515 predominantly white children and their parents.

Methods

Children's separation anxiety (CSA), depression, and other anxiety disorders were modeled as latent factors using diagnoses from interviews and symptom scores from questionnaires completed by mothers, fathers, and children when children were 9 years old and again 3 years later. Parents' separation anxiety was assessed via a questionnaire and parents' other anxiety, depressive, and substance use disorders were assessed with a diagnostic interview when children were nine. Relationships between parents' and children's psychopathology were modeled using s.e.m.

Results

Mothers' and fathers' ASA were related to all three psychopathology factors in offspring, over and above other parental disorders, in concurrent and prospective analyses. CSA was also related to maternal depression concurrently and prospectively and to maternal anxiety prospectively. Of all paternal psychopathology variables, only ASA was significantly related to children's psychopathology in either model.

Conclusions

Results indicate that parental separation anxiety is an important, but non-specific, risk factor for children's psychopathology. The pathway by which this risk is transmitted may be genetic or environmental, and the observed statistical associations likely also encompass child-to-parent effects.