bluuebunny/crossref_metadata_2025 huggingface dataset:
Функции государственной жилищной политики в Республике Беларусь
Authors: Еременко Марина Михайловна
Published: November 2018

Вмешательство государства в жилищную сферу необходимо в той или иной мере в любой стране при любом экономическом укладе. При этом, открытым остается вопрос, какие именно аспекты жилищной сферы нуждаются в государственном вмешательстве. Целью работы явилось формирование наиболее полной системы функций государственной жилищной политики (далее – ГЖП) любой страны, а также выявление их содержания. Различные авторы по-разному рассматривают функции, инструменты и мероприятия ГЖП, при этом ни один из них не приводит классификационных признаков, по которым они сгруппированы. Кроме того, набор функций, инструментов и мероприятий в жилищной сфере у всех авторов различный. Существуют и публикации, где авторы рассматривают только одну или несколько функций без их классификации. Так, анализ литературы по теме исследования, изучение мирового и отечественного опыта, а также собственные исследования автора позволили впервые предложить авторский подход к формированию наиболее полной системы функций ГЖП, в основу которого положен такой классификационный признак, как специфика объектов государственного воздействия. В статье обобщен и систематизирован авторский перечень функций ГЖП, который состоит из экономической, правовой, социальной, управленческо-финансовой, экологической, технической, охранной и информационной функций. Также, в статье представлен обзор выполнения функций ГЖП Республики Беларусь. Результаты исследования могут быть использованы органами государственного управления для принятия управленческих решений в области ГЖП.
Dehydration of Methylbutenes to Isoprene. Part 3: Comparative Mathematical Analysis of Methylbutene Dehydrogenation in Axial and Radial Reactors
Authors: Gilmurakhmanov B. Sh. , Urtyakov P. V. , Nazarov M. V. , Roshchina O. S. , Lamberov A. A.
Published: November 2018

A mathematical model of the process of dehydrogenation of methylbutenes to isoprene was used for comparative analysis of energetic efficiency of two versions of modernization: (1) a system of consecutively connected two axial reactors with a fixed catalyst beds, and (2) adiabatic radial reactor with fixed catalyst bed. The purpose was to determine the dependence of yield (Y) and selectivity (S) to the target product on the heat energyQsupplied with vapor. In the two-reactor system, the best parameters (Y= 53.1 % andS= 82.9 %) were achieved atQ= 9.0 MJ/kg and contact time t = 0.8 s. At the same time, in the radial reactor the best performance (Y= 42.0 % andS= 86.1 %) was observed atQ= 7.8 MJ/kg andt= 0.8 s. Hence, the radial reactor consumes less heat energy (by 13.0 %) than the radial reactor for methylbutene dehydrogenation.
Turismo y capital social: vacíos y oportunidades de investigación
Authors: Ramírez Hernández Omar Ismael , Cruz Jiménez Graciela , Serrano Barquín Rocío del Carmen
Published: November 2018

Este artículo aporta nuevas oportunidades de investigación centradas en el capital social y el turismo. Aunque este tipo de capital ha permitido explicar una amplia gama de fenómenos sociales, su análisis en el contexto turístico aún es incipiente. La contribución se realiza a partir de las siguientes limitaciones detectadas en la literatura sobre la incorporación del capital social al estudio del turismo: las diferentes conceptualizaciones utilizadas, los diversos procedimientos para medirlo y la inclusión de solo algunos grupos de actores a su análisis. Otra limitante se refiere a que en la literatura solo se reconoce el binomio turismo-capital social como una forma de alcanzar el desarrollo turístico. Una de las principales conclusiones de este artículo es que esta actividad ha sido poco considerada como un agente de cambio en los destinos turísticos, además del incipiente reconocimiento de su influencia en el capital social de los actores vinculados a ella.
The management of Bochdalek congenital diaphragmatic hernia: a single center experience and review of the literature
Authors: OKAY Sefer Tolga , SANCAR Serpil , ÖZÇAKIR Esra , GÜNEY VARAL İpek , DOĞAN Pelin , KAYA Mete
Published: November 2018

Objectives:
Congenital diaphragmatic hernia (CDH) is a rare congenital anomaly of the
diaphragm with pulmonary hypoplasia and persistent pulmonary hypertension and
has serious consequences. Despite recent diagnosis and treatment strategies,
CDH is still a challenging condition. We aim to present our clinical
experiences of CDH, and review of the literature. Methods: Data of
CDH patients who were operated in our clinic between January 2010 and September
2018 were obtained from the patient's chart. The clinical course and results of
the patients with Bochdalek type CDH were reviewed. Results: We
performed diaphragmatic closure in 16 patients with Bochdalek CDH during study
period. Fourteen (82%) cases were diagnosed antenatally. In 5 (29%) patients,
preoperative pulmonary hypertension developed and nitric oxide was
administered. Twelve of the sixteen patients (75%) underwent primary repair and
4 of them underwent prosthetic patch. Three patients were repaired
thoracoscopically. Five (31%) patients died due to severe persistent pulmonary
hypertension on postoperative period. There was no recurrence in our patients
who were followed-up for a mean of 27 months.

Conclusion: In
the management of Bochdalek CDH, the clinical success has been increasing in
parallel with the important developments with the application of new treatment
modalities in the neonatal intensive care units and new surgical techniques in
recent years.
Effect of concept cartoons used in teaching the mole concept
Authors: Akben Nimet
Published: November 2018

Visual materials that can be used in classes such as PowerPoint presentations, analogies, documentaries and concept cartoons appeal to more than one sense of students and thus enable them to be more active in the learning process and learn more permanently by structuring knowledge in their minds more easily. In concept cartoons used to discover studentsâ€™ conceptual structures and develop their comprehension, the intention is to create a discussion environment to reach knowledge by discussions without giving the answers directly. With this purpose, primary school candidates were given a variety of pictures and concept cartoons regarding the mole concept in the general chemistry class in order to explore the effect of these images on the concept learning as well as evaluating their view. This studyâ€™s result was parallel to the results of the studies that suggest that concept cartoons are effective on improving student success and developing a positive opinion.

Keywords: Concept cartoons, chemistry education, mole concept.
The Top Ten Things Parents Want to Hear From You in the NICU
Authors: Discenza Deborah
Published: November 2018

Connecting with a family is a huge challenge for nurses as they are more focused on the technical aspects of caring for the premature infant in the NICU. In this column, the top ten things parents want to hear from nurses in a variety of scenarios help to provide insight into the patient family mind-set and how to best work with them.
‘Universo feminino e masculino’: análise do discurso parental sobre meninos e meninas
Authors: Campos Maria Teresa de Assis , Tilio Rafael de
Published: November 2018

Este estudo teve como objetivo identificar as Formações Discursivas presentes nos discursos de pais de meninos e meninas sobre o feminino e o masculino. Participaram dele cinco casais heterossexuais, com pelo menos um filho e uma filha. Os dados coletados foram analisados à luz da Análise do Discurso de Michel Pêcheux, e indicaram que as famílias reproduzem em seus discursos e práticas estereótipos tradicionais de gênero, respondendo a Formação Ideológica heteronormativa e binária que acentua a dominação do masculino sobre o feminino. Ao final, percebeu-se que a família se caracteriza como importante núcleo interventivo na tentativa de reconfigurar as alternativas discursivas no campo da sexualidade e gênero, criando autonomia e espaços seguros para mulheres e sujeitos dissidentes da heteronorma.
Análise fonético-acústica de disfarces vocais com aplicações para a fonética forense
Authors: Passetti Renata Regina , Barbosa Plínio Almeida
Published: November 2018

Esta pesquisa avaliou quais parâmetros acústicos foram modificados e quais permaneceram inalterados na fala de indivíduos durante a utilização de dois disfarces vocais: um envolvendo a utilização de um lápis posicionado atrás dos dentes incisivos e outro buscando imitar a fala do apresentador de televisão Sílvio Santos. O corpus foi composto por amostras de fala de três locutores do sexo masculino que leram a transcrição de um discurso deste apresentador em três situações: (1) utilizando seus padrões de fala habituais; (2) imitando o apresentador Sílvio Santos; e (3) utilizando um lápis na boca. Foram analisadas as frequências dos dois primeiros formantes; frequência fundamental, por meio dos descritores estatísticos mediana e valor de base; ênfase espectral; duração das vogais orais do português brasileiro e das pausas silenciosas; e a duração entre dois picos consecutivos da frequência fundamental. Os resultados mostram que os locutores conseguiram desviar da própria fala por meio de alterações na entonação, no esforço vocal, em alongamentos vocálicos e por alterações no tempo global do discurso. As alterações nas frequências formânticas resultaram na reconfiguração do espaço vocálico. Essas modificações estavam associadas ao desejo de alcançar o registro vocal do locutor-alvo, no caso da imitação, ou às restrições impostas pelo uso do lápis na boca. Não foram atestadas modificações significativas nos valores obtidos para a duração interpicos da frequência fundamental para nenhum dos locutores.
A produção textual escrita: junção e(m) aquisição
Authors: Lopes-Damasio Lúcia Regiane , Silva Patrícia Celene Senna da
Published: November 2018

Neste artigo, investigamos a constituição de tradições discursivas (TDs), na aquisição da escrita infantil, com base na ideia de que os mecanismos de junção do texto, em espaços determinados, são sintomáticos de TDs e vice-versa. Adotando um quadro teórico em que a descrição da escrita infantil é pautada na consideração conjunta de aspectos linguísticos e pragmático-discursivos, os resultados, alcançados a partir de uma análise de cunho qualitativo e quantitativo, mostram evidências de dois tipos de relações passíveis de serem estabelecidas entre esses mecanismos e as TDs focalizadas: (i) com as TDs narração, relato, argumentativa e explicativa, em que a repetibilidade dos espaços de junção preenchidos por mecanismos com acepção causal reafirma a hipótese que caracteriza o aspecto sintomático entre a TD que se constitui e a forma como os encadeamentos dessa natureza a constituem; e (ii) com as TDs cartão de Natal, injuntiva e pedido, em que o uso dos mecanismos de junção causal está relacionado à mescla de TDs, diretamente associada à parte do texto em que são inseridas TDs explicativas/argumentativas. Por isso, nessas TDs, a repetibilidade dos mecanismos de junção causal não pode ser o ponto de partida da análise, mas, sim, o seu papel pragmático-discursivo como matéria que constitui a composicionalidade da tradição textual.
A Fênix finalmente renascida: filologia, história e língua: olhares sobre o português medieval
Authors: Módolo Marcelo , Ackel Antonio
Published: November 2018

Este livro foi escrito por quatro pesquisadores – três da área de Letras (com especialização em filologia, linguística histórica e história da língua portuguesa) e um da área de História (com especialização em história medieval) – e preenche uma lacuna da nossa bibliografia. Temos boas gramáticas históricas da língua portuguesa e estamos razoavelmente bem servidos de introduções à linguística histórica, à filologia e à teoria da história. Faltava, porém, um livro que pudesse servir de apoio aos cursos voltados especificamente à preparação dos estudantes para a leitura, edição e comentário de textos de sincronias passadas, em particular de manuscritos medievais. Igualmente, um volume que conjugasse e entrecruzasse os vários olhares envolvidos nessas atividades – o olhar filológico, o histórico-linguístico e o histórico; traçando um percurso pormenorizado, bem exemplificado e bem recheado de atividades complementares para auxiliar os estudantes a alcançar autonomia no trabalho analítico. A lacuna foi preenchida com este volume redigido por Leonardo Lennertz Marcotulio, Célia Regina dos Santos Lopes, Mário Jorge da Motta Bastos e Thiago Laurentino de Oliveira. Os autores combinam com maestria os saberes técnicos, a sensibilidade didática e a paixão por uma atividade que é árdua, mas indispensável.
Apresentação
Authors: Novaes Rosana do Carmo
Published: November 2018

Temos o prazer de informar aos nossos leitores que acaba de ser lançado o Volume 60(3) de 2018 da Cadernos de Estudos Linguísticos, que conta com a colaboração de 23 autores em 2 resenhas e 16 artigos das mais diversas áreas da Linguística e de suas interfaces.
The Continuance Intention of User’s Engagement in Multiplayer Video Games based on Uses and Gratifications Theory
Authors: Puspitasari Ira , Syahputra Elzha Odie , Raharjana Indra Kharisma , Jie Ferry
Published: November 2018

One of the key success factors in video game industry, including multiplayer video game (MVG), is the user’s continuance intention. The MVG industry runs in a highly competitive market. Users can shift to another game as soon as they discover a slightly inconvenient issue. Thus, maintaining the user’s enthusiasm in playing MVG for a long time is challenging for most games. The solution to prolong the users’ engagement can be initiated by identifying all factors that facilitate the continuance use of playing MVG. This study applied uses and gratifications theory to examine seven variables (enjoyment, fantasy, escapism, social interaction, social presence, achievement, and self-presentation) and the moderating effects of age and gender on the MVG continuance intention. The data analysis and the model development were tested based on Partial Least Square method using the responses of 453 MVG users. The results revealed that enjoyment, fantasy, social interaction, achievement, and self-presentation significantly affected the continuance intention of playing MVG, with enjoyment being the strongest variable. The result also demonstrated the moderating effect of age and gender on the relation between independent variables and continuance intention. The results and findings offered additional insights into the system development to enhance the information system application.
Potential European Emissions Trajectories within the Global Carbon Budget
Authors: Perissi Ilaria , Sara Falsini , Bardi Ugo , Natalini Davide , Green Michael , Jones Aled , Solé Jordi
Published: November 2018

The Global Carbon Budget is the cumulative carbon emissions that human activities can generate while limiting the global temperature increase to less than 2°C. On this basis, most countries ratified the Paris Agreement 2015, pledging to reduce national emissions and the impacts of climate change. The European Union has planned to reduce emissions by 80% of their 1990 value by 2050 but such a target needs to be coupled with a further constraint on the cumulative greenhouse gases released along the path to 2050. The aim and the novelty of this study are to propose, for the first time, a carbon budget for the European Union, which represents the most significant physical characteristic to assess the feasibility of current EU-28 greenhouse gas reduction objectives under the goals of the 2015 Paris treaty
Natural Computing Applied to the Underground System: A Synergistic Approach for Smart Cities
Authors: Morales Lucas Clemencio , de Mingo Lopez Luis Fernando , Gómez Blas Nuria
Published: November 2018

The management and proper use of the Urban Public Transport Systems (UPTS) constitutes a critical field that has not been investigated in accordance to its relevance and urgent idiosyncrasy within smart cities realm. Swarm Intelligence is a very promising paradigm to deal with such complex and dynamic systems. It presents robust, scalable and self-organized behaviour to deal with dynamic and fast changing systems. The intelligence of cities can be modelled as a swarm of digital telecommunication networks (the nerves), ubiquitously embedded intelligence, sensors and tags, and software. In this paper, a new approach based on the use of the Natural Computing paradigm and Collective Computation is shown, more concretely taking advantage of an Ant Colony Optimization algorithm variation and Fireworks algorithms in order to build a system that makes the complete control of the UPTS a tangible reality.
Introduction of an Experimental Terrestrial Forecasting/Monitoring System at Regional to Continental Scales Based on the Terrestrial System Modeling Platform (v1.1.0)
Authors: Kollet Stefan , Gasper Fabian , Brdar Slavko , Goergen Klaus , Hendricks-Franssen Harrie-Jan , Keune Jessica , Kurtz Wolfgang , Küll Volker , Pappenberger Florian , Poll Stefan , Trömel Silke , Shrestha Prabhakar , Simmer Clemens , Sulis Mauro
Published: November 2018

Operational weather and also flood forecasting has been performed successfully for decades and is of great socioeconomic importance. Up to now, forecast products focus on atmospheric variables, such as precipitation, air temperature and, in hydrology, on river discharge. Considering the full terrestrial system from groundwater across the land surface into the atmosphere, a number of important hydrologic variables are missing especially with regard to the shallow and deeper subsurface (e.g. groundwater), which are gaining considerable attention in the context of global change. In this study, we propose a terrestrial monitoring/forecasting system using the Terrestrial Systems Modeling Platform (TSMP) that predicts all essential states and fluxes of the terrestrial hydrologic and energy cycles from groundwater into the atmosphere. Closure of the terrestrial cycles provides a physically consistent picture of the terrestrial system in TSMP. TSMP has been implemented over a regional domain over North Rhine-Westphalia and a continental domain over European in a real-time forecast/monitoring workflow. Applying a real-time forecasting/monitoring workflow over both domains, experimental forecasts are being produced with different lead times since the beginning of 2016. Real-time forecast/monitoring products encompass all compartments of the terrestrial system including additional hydrologic variables, such as plant available soil water, groundwater table depth, and groundwater recharge and storage.
Non-flat Earth Recalibrated for Terrain and Rugged Soil Relief
Authors: Blakemore Robert J.
Published: November 2018

Earth’s land surface area is raised from conventionally flat 15 to 64 Gha to account for hilly undulation and soil relief detail. Three main aspects are: topography, rugosity/tortuosity and micro-relief/porosity of vegetation-free ground. Recalibration is arrived at from four approaches: first, direct empirical estimates from the few compiled satellite or LiDAR data with means of +2.5–26% progressively overlain by +94% at cm2 scale for soil ruggedness then +108% for mm2 micro-relief; second, from digital elevation models with 1.6–2.0 times flat areas; third, by ‘reverse engineering’ global soil bulk densities and carbon reserves requiring x 2–6 land. Finally, a Fermi estimation conveniently sets the World’s new surface area – that exposed to Sun, air and rain – at 100 Gha (with 36 Gha flat ocean). Soil organic carbon (SOC) is thence raised to 8,580 Gt mainly in SOM/humus with its biotic complexity plus roots, VAM-fungi and leaf-litter, that itself = 17,800 Gt. Although four to six times IPCC’s or NASA/NOAA’s calculations of just 1,500–2,300 Gt SOC, this is likely an underestimation. Global biomass and biodiversity are at least doubled (x 2–3.5) and net primary productivity (NPP) similarly increased on land to >270 Gt C yr-1 due to terrain.
Supplementing Dairy Ewes Grazing Low Quality Pastures with Plant-Derived Oils and Rumen-Protected EPA+DHA Pellets Improves Lactation Traits and Body Condition Score
Authors: Nguyen Quang V. , Le Hung V. , Nguyen Don V. , Nish Peter , Otto John R. , Malau-Aduli Bunmi S. , Nichols Peter D. , Malau-Aduli Aduli E.O.
Published: November 2018

The Australian dairy sheep industry is small and mostly based on a natural grass grazing system which can limit productivity. The current study tested different plant oil-infused and rumen protected polyunsaturated fats and their interactions with sire breeds to improve lactation traits and body condition score (BCS) of ewes grazing low quality pastures. It was hypothesised that supplementing lactating ewe diets plant-derived polyunsaturated oils will improve milk production and composition without compromising BCS. Sixty ewes (n=10/treatment) in mid-lactation, balanced by sire breed, parity, milk yield, body condition score, and liveweight were supplemented with: 1) control: wheat-based pellets without oil inclusion; wheat-based pellets including 2) canola oil (CO); 3) rice bran oil (RBO); 4) flaxseed oil (FSO), 5); safflower oil (SFO) and 6) rumen protected fat containing eicosapentaenoic acid and docosahexaenoic acid (RPO).  Except for the control group, all supplementary diets included the same level of 50 ml/kg DM of oil and all diets were isocaloric and isonitrogenous. Experimental animals were grazed in the same paddock with ad libitum access to pasture, hay and water during the 10-week study. RPO was the most effective diet that enhanced milk, fat and protein yields by approximately 30, 13, and 31% respectively (P<0.0001). Significant increase in milk production was also observed in CO, RBO, and SFO (P<0.0001). Breed significantly influenced animal performance with higher milk yield recorded for crossbred Awassi x East Friesian (AW x EF) (578 g/day) vs purebred Awassi (452 g/day) (P<0.0001). This study provides empirical evidence for the use of rumen-protected and plant-derived oil-infused pellets as supplements under low quality pasture grazing conditions, to improve production performance of purebred Awassi and crossbred AW x EF ewes.
Computational Topology Techniques Help to Solve a Long-Lasting Forensic Dilemma: Aldo Moro’s Death
Authors: Peters James F. , Tozzi Arturo
Published: November 2018

Here we show how a recently-introduced method from algebraic topology, namely proximal planar vortex 1-cycles, might be helpful in detecting hidden features of the shapes and holes in images, therefore contributing to the solution of both cold and fresh forensic cases. In particular, we test the efficacy of this technique by assessing one of the most puzzling cases of recent history, i.e., Aldo Moro’s death. Terrorists of the Red Brigades claimed that they killed Moro when he was placed inside the trunk of a car,shooting him with a barrage of bullets. We demonstrate, based on the analysis of the photographs taken during the autoptic procedure, that the terrorist’s account does not hold true. Our results, showing different series of shots, point towards a three-step execution, with the first phasestaking place outside the car. In conclusion, the novel forensic analysis method introduced in this paper permits the evaluation of a collection of vortex cycles/nerves equipped with a connectedness proximity, which makes it possible to assess unexpected spatial clusters in photographs.
${\rm {\bf UL}}_\omega $ and ${\rm {\bf IUL}}_\omega $ Are Substructural Fuzzy Logics
Authors: Wang SanMin
Published: November 2018

Two representable substructural logics ${\rm {\bf UL}}_\omega $ and ${\rm {\bf IUL}}_\omega $ are logics for finite UL and IUL-algebras, respectively. In this paper, the standard completeness of ${\rm {\bf UL}}_\omega $ and ${\rm {\bf IUL}}_\omega $ is proved by the method developed by Jenei, Montagna, Esteva, Gispert, Godo and Wang. This shows that ${\rm {\bf UL}}_\omega $ and ${\rm {\bf IUL}}_\omega $ are substructural fuzzy logics.
Acidic Gases Separation from Gas Mixtures on the SILMs Providing the Facilitated and Solution-Diffusion Transport Mechanisms
Authors: Akhmetshina Alsu I. , Mochalova Alla , Trubyanov Maxim M. , Atlaskin Artem A. , Yanbikov Nail R. , Mechergui Amal , Otvagina Kseniya V. , Razov Evgeny N. , Vorotyntsev Ilya V.
Published: November 2018

Nowadays, the imidazolium-based ionic liquids containing acetate counter-ions are attracting much attention as both highly selective absorbents of the acidic gases and CO2 carriers in the supported ionic liquid membranes. In this regard, the investigation of the gas transport properties of such membranes may be appropriate for better understanding of various factors affecting the separation performance and the selection of the optimal operating conditions. In this work, we have tested CH4, CO2 and H2S permeability across the SILM impregnated by 1-butyl-3-methylimidazolium acetate (bmim[ace]) with the following determination of the ideal selectivity in order to compare the facilitated transport membrane performance with the SILM that dissolves acidic gases physically, namely, containing 1-butyl-3-methylimidazolium tetrafluoroborate (bmim[BF4]). Both SILMs have showed modest individual gases permeability and ideal selectivity of CO2/CH4 and H2S/CH4 separation that achieves values up to 15 and 32, respectively. The effect of the feed gas mixture composition on the permeability of acidic gases and permeselectivity of the gas pair was investigated. It turned out that the permeation behavior for the bmim[ace]-based SILM toward the binary CO2/CH4, H2S/CH4 and ternary CO2/H2S/CH4 mixtures was featured with high acidic gases selectivity due to the relatively low methane penetration through the liquid phase saturated by acidic gases.
Endoscopic Stenting for Colorectal Cancer. The Importance of Collaboration between Specialists
Authors: Sterpetti Antonio V , Lamazza Antonietta , Di Marzo Luca , Fiori Enrico
Published: November 2018

BACKGROUND: Endoscopic placement of Self Expandable Metal Stents to relieve malignant colorectal obstruction has become a common therapeutic  advancement in clinical practice. MATERIAL: In a 16 year period 167 patients had endoscopic placement of a Self Expandable Metal Stent  in a center where gastroenterologists and surgeons cooperate in  a daily basis, discussing indications. RESULTS: There was no operative mortality and no major complication in placement of the stent. Technical and clinical success was respectively 95.1% and 92.9%. Consultation among specialists changed the preoperative indication in 60 patients, during the same time period. CONCLUSIONS: Self expandable metal stents placement represents an important tool to treat patients with obstructing colorectal cancer and complications after colorectal resection . A proper training is required, and this training in operative endoscopy is not always available and possible. In this scenario, a close collaboration among specialists in selecting the most appropriate operative procedure is essential and brings to better results.
9,10-Phenanthrenedione as Visible-Light Photoredox Catalyst: A Green Methodology for the Functionalization of 3,4-Dihydro-1,4-Benzoxazin-2-ones through a Friedel-Crafts Reaction
Authors: Rostoll-Berenguer Jaume , Blay Gonzalo , Pedro José R. , Vila Carlos
Published: November 2018

A visible-light photoredox functionalization of 3,4-dihydro-1,4-benzoxazin-2-ones through a Friedel-Crafts reaction with indoles using an inexpensive organophotoredox catalyst is described. The reaction uses a dual catalytic system formed by a photocatalyst simple and cheap, 9,10-phenanthrenedione, and a Lewis acid, Zn(OTf)2. 5W white LEDs are used as visible-light source and oxygen from air as a terminal oxidant, obtaining the corresponding products with good yields. The reaction can be extended to other electron-rich arenes.
Poisson-Gamma Mixture Spatially Varying Coefficient Modeling of Small-Area Intestinal Parasites Infection
Authors: Osei Frank Badu , Stein Alfred , Ofosu Anthony
Published: November 2018

Understanding the spatially varying effects of demographic factors on the spatio-temporal variation of intestinal parasites infections is important for public health intervention and monitoring. This paper presents a hierarchical Bayesian spatially varying coefficient model to evaluate the effects demographic factors on intestinal parasites morbidities in Ghana. The modeling relied on morbidity data collected by the District Health Information Management Systems. We developed Poisson and Poisson-gamma spatially varying coefficient Models. We used the demographic factors, unsafe drinking water, unsafe toilet and unsafe liquid waste disposal as model covariates. The models were fitted using the Integrated Nested Laplace Approximations (INLA). The overall risk of intestinal parasites infection was estimated to be 10.9 per 100 people with a wide spatial variation in the district-specific posterior risk estimates. Substantial spatial variation of increasing multiplicative effects of unsafe drinking water, unsafe toilet and unsafe liquid waste disposal occurs on the variation of intestinal parasites risk. The structured residual spatial variation widely dominates the unstructured component, suggesting that the unaccounted-for risk factors are spatially continuous in nature. The study concludes that both the spatial distribution of the posterior risk and the associated exceedance probability maps are essential for monitoring and control of intestinal parasites.
Optimization of Thermoplastic Blend Matrix HDPE/PLA with Different Nature and Level of Coupling Agent
Authors: Quitadamo Alessia , Massardier Valérie , Santulli Carlo , Valente Marco
Published: November 2018

High density polyethylene (HDPE) and poly(lactic) acid (PLA) blends with different ratios of both polymers, namely 30:70, 50:50 and 70:30, were produced. Polyethylene grafted maleic anhydride and a random copolymer of ethylene and glycidyl methacrylate, were also proposed as compatibilizers to modify HDPE-PLA optimal blends and were added in the amounts of 1, 3 and 5 wt.%. Blends properties have been evaluated through different aspects by performing tensile tests, scanning electron microscopy to analyze blend morphology and interfaces, and thermomechanical analysis through differential scanning calorimetry, thermo-gravimetric analyses and infrared spectroscopy. The second blend, the one with equal amounts of HDPE and PLA seems to represent a good balance between high amount of bio-derived charge and acceptable mechanical properties. This suggests a good potential of these blends, which would be a good starting point for the production of composites with lingo-cellulosic fillers.
Stochastic Thermodynamics of Oscillators' Networks
Authors: Borlenghi Simone , Delin Anna
Published: November 2018

We apply the stochastic thermodynamics formalism to describe the dynamics of systems of complex Langevin and Fokker-Planck equations. We provide in particular a simple and general recipe to calculate thermodynamical currents, dissipated and propagating heat for networks of nonlinear oscillators. By using the Hodge decomposition of thermodynamical forces and fluxes, we derive a formula for entropy production that generalises the notion of non-potential forces and makes transparent the breaking of detailed balance and of time reversal symmetry for states arbitrarily far from equilibrium. Our formalism is then applied to describe the off-equilibrium thermodynamics of a few examples, notably a continuum ferromagnet, a network of classical spin-oscillators and the Frenkel-Kontorova model of nano friction.
An Informational Test for Random Finite Strings
Authors: Bonnici Vincenzo , Manca Vincenzo
Published: November 2018

In this paper, by extending some results of informational genomics, we present a new randomness test based on the empirical entropy of strings and some properties of repeatability and unrepeatability of substrings of certain lengths. We give the theoretical motivations of our method and some experimental results of its application to a wide class of strings: decimal representations of real numbers, roulette outcomes, logistic maps, linear congruential generators, quantum measurements, natural language texts, and genomes. It will be evident that the evaluation of randomness resulting from our tests does not distinguish among the different sources of randomness (natural, or pseudo-casual).
Supplementing Conjugated and Non-Conjugated L-Methionine and Acetate Alters Expression Patterns of β-Casein, Proteins, and Metabolites Related to Protein Synthesis in Bovine Mammary Cells
Authors: Conejos Jay Ronel , Jeon S. W. , Kim J. E. , Kim M. J. , Lee J. E. , Lee B. S. , Park J. S. , Moon J. O. , Lee J.S. , Lee Hong-Gu
Published: November 2018

The study was done to determine the effect of supplementing different forms of L-methionine (L-Met) and acetate on protein synthesis in immortalized bovine mammary epithelial cell line (MAC-T Cell): Control, L-Met, conjugated L-Met and acetate (CMA), and non-conjugated L-Met and Acetate (NMA). Protein synthesis mechanism was determined by omics method. NMA group had the highest protein content in the media and β-casein mRNA expression levels (P < 0.05). The number of upregulated and downregulated proteins observed were 77 and 62 in CMA group and 50 and 81 in NMA group from 448 proteins, respectively (P < 0.05). NMA and CMA treatments stimulated pathways related to protein and energy metabolism (P < 0.05). Metabolomic analysis also revealed CMA and NMA treatments resulted in increases of several metabolites (P < 0.05). In conclusion, NMA treatment increased protein concentration and expression level of β-casein mRNA in MAC-T cells compared to CMA.
Automatic Thin Cap Fibroatheroma Detection Using Fusion of Intravascular Ultrasound and Virtual Histology Images
Authors: Rezaei Zahra , Selamat Ali , Taki Arash , Mohd Rahim Mohd Shafry , Abdul Kadir Mohammed Rafiq , Fujita Hamido , Videma Harera Enrique , Krejcar Ondrej
Published: November 2018

Virtual Histology- Intravascular Ultrasound (VH-IVUS) image is an available method for visualizing plaque component to detect thin cap fibroatheroma. Nevertheless, this imaging modality has considerable limitations to extract the plaque component features and identifying the TCFA plaque. The aim of this paper is to improve the identification of TCFA using fusion of IVUS and VH-IVUS images. In order to generate the automatic technique for reducing the human interaction, a new method namely Active Contour based Plaque Border Detection (ACPB) is proposed. In order to perform the pixel wise classification, hybrid of K-means algorithm with Particle Swarm Optimization and Plaque based Minimum Euclidean Distance (KMPSO-PMED) method is presented to classify the plaque region as well. Moreover, to obtain more significant information of imaging modalities, fusion of two different images consisting of VH-IVUS and IVUS is performed. Therefore, geometric features are extracted from the plaque region and combine with IVUS features. Furthermore, different group of plaque features are divided by means of the histopathological studies. SVM classifiers is applied to detect the TCFA and non-TCFA plaques. The proposed method is applied on 566 in-vivo IVUS and their matching VH-IVUS images obtained from 9 patients. The best result of SVM illustrates the accuracy rates of 99.41% for classification of TCFA plaque. The results prove that the highest accuracy is achieved by integrated features of IVUS and VH-IVUS images.
Using Recurrent Procedures in Adaptive control System for Identify the Model Parameters of the Moving Vessel on the Cross Slipway
Authors: Rudakova Hanna , Polyvoda Oksana , Omelchuk Anton
Published: November 2018

The article analyzes the problems connected with ensuring the coordinated operation of slipway drives that arise during the launch of a ship. The dynamic model of load of the electric drive of the ship's cart is obtained taking into account the peculiarities of the construction of the ship-lifting complex, which allows to analyze the influence of external factors and random influences during the entire process of launching the ship. A linearized mathematical model of the dynamics of a complex vessel movement in the process of descent in the space of states is developed, which allows to identify the mode of operation of the multi-drive system, taking into account its structure. The analysis of efficiency of application of recurrent methods of identification (stochastic approximation and least squares) of the parameters of the linearized model in the space of states is carried out. A decision support system has been developed in the automated system of operational control by the module for estimating the situation and the control synthesis to ensure a coherent motion of a complex ship-carts object in a two-phase environment.
Catalytic Hot Gas Filtration for Tailoring Vapor-Phase Chemistry of Fast Pyrolysis Bio-Oils
Authors: Lu Mi , Lepore Andrew , Choi Jae-Soon , Li Zhenglong , Wu Zili , Polo Garzon Felipe , Hu Michael Z.
Published: November 2018

Carboxylic acids such as acetic acid and propionic acid have been investigated as representative components for fast pyrolysis (FP) bio-oil upgrading. Selective catalytic conversion of carboxylic acids can enhance bio-refinery processing economics through catalyst preservation and process intensification. Various metal-doped molybdenum carbide bead catalysts have been synthesized and developed in this work.  Our aim is to enable selective conversion of carboxylic acids. In the case of acetic acid conversion, calcium doped Mo2C beads offer the highest yield of acetone ~96% at 450 °C among undoped and Ca or Ni doped catalysts. By comparing hot gas filter with and without Ca-Mo2C catalyst tested with real FP vapors, the former showed a 36.7% reduction of acetic acid, a 37.5% reduction of small ketones in aqueous phase, and a ~50% reduction of methoxies (methoxy phenols and methoxy aromatics) in organic phase. The conversion resulted in the formation of more long chain chemicals in the organic phase, which are more amendable for downstream upgrading.
Novel Insights into the Crosstalk between Mineralocorticoid Receptor and G Protein-Coupled Receptors in Heart Adverse Remodeling and Disease
Authors: Parker Barbara M. , Wertz Shelby L. , Pollard Celina M. , Desimine Victoria L. , Maning Jennifer , McCrink Katie A. , Lymperopoulos Anastasios
Published: November 2018

The mineralocorticoid hormone aldosterone regulates sodium and potassium homeostasis but also adversely modulates the maladaptive process of cardiac adverse remodeling post-myocardial infarction. Through activation of its mineralocorticoid receptor (MR), a classic steroid hormone receptor/transcription factor, aldosterone promotes inflammation and fibrosis of the heart, the vasculature, and the kidneys. This is why MR antagonists reduce morbidity and mortality of heart disease patients and are part of the mainstay pharmacotherapy of advanced human heart failure. A plethora of animal studies using cell type–specific targeting of the MR gene have established the importance of MR signaling and function in cardiac myocytes, vascular endothelial and smooth muscle cells, renal cells, and macrophages. In terms of its signaling properties, the MR is distinct from nuclear receptors in that it has, in reality, two physiological hormonal agonists: not only aldosterone but also cortisol. In fact, in several tissues, including in the myocardium, cortisol is the primary hormone activating the MR. There is a considerable amount of evidence indicating that the effects of the MR in each tissue expressing it depend on tissue- and ligand-specific engagement of molecular co-regulators that either activate or suppress its transcriptional activity. Identification of these co-regulators for every ligand that interacts with the MR in the heart (and in other tissues) is of utmost importance therapeutically, since it can not only help elucidate fully the pathophysiological ramifications of the cardiac MR`s actions but also help design and develop novel better MR antagonist drugs for heart disease therapy.  Among the various proteins the MR interacts with are molecules involved in cardiac G protein-coupled receptor (GPCR) signaling. This results in a significant amount of crosstalk between GPCRs and the MR, which can affect the latter`s activity dramatically in the heart and in other cardiovascular tissues. This review summarizes the current experimental evidence for this GPCR-MR crosstalk in the heart and discusses its pathophysiological implications for cardiac adverse remodeling as well as for heart disease therapy. Novel findings revealing non-conventional roles of GPCR signaling molecules, specifically of GPCR-kinase (GRK)-5, in cardiac MR regulation are also highlighted.
ISSUES OF ADMISSION TO PHYSICAL ACTIVITY IN PEDIATRICS AND CHILDREN’S CARDIOLOGY
Authors: Gnusaev S. F. , Konopko N. N.
Published: November 2018

The article analyzes a regulatory base for admission of children and adolescents to physical culture, sports, conformity with the standards of preparedness for work and defense, recommended tests for determining tolerance to physical activity. The article reveals issues of admission to various types of physical activity: ways to assess tolerance to physical exercises, the right for admission to various types of physical activity.
SURGICAL ASPECTS OF CELIAC DISEASE
Authors: Shakirova A. R. , Kamalova A. A. , Yafasov R. Ya. , Nizamova R. A.
Published: November 2018

There are publications on the association of celiac disease with intussusception and intestinal obstruction in adults. Although intussusception is the most common cause of intestinal obstruction in children, it is rarely considered in association with celiac disease. The article presents clinical cases of a rare manifestation of celiac disease with acute surgical pathology – acute intestinal obstruction due to the intestinal intussusception and obstruction. Children with intussusception with non-established etiology should be examined for celiac disease, especially when they have the appropriate symptoms – growth retardation, anemia, bloating, increased transaminase levels and other manifestations of celiac disease, and in case the child’s age is not entirely characteristic of the intussusception.
NATAL INJURIES OF VISCERAL ORGANS
Authors: Morozov V. I. , Podshivalin A. A. , Chigvintsev G. E. , Yulmetov G. A.
Published: November 2018

The article describes surgical diseases of newborns after a trauma of central nervous system in the perinatal period. There is a detailed diagnostic and therapeutic tactics for injuries of internal organs. There is a clinical case of natal injury, leading to severe multi-organ failure and death.
THE ROLE OF CONNECTIVE TISSUE DYSPLASIA IN CHILDREN’S CYSTIC FIBROSIS. CLINICAL AND GENETIC ASPECTS
Authors: Goryainova A. V. , Shumilov P. V. , Kashirskaya N. Yu. , Semykin S. Yu.
Published: November 2018

The article considers the issue of cystic fibrosis – a monogenic autosomal recessive disease. It describes the history of the CFTR gene discovery, the further search for modifier genes to explain the variability of the clinical manifestations of cystic fibrosis. The review discusses problems of connective tissue dysplasia and somatic pathology, which is formed due to the connective tissue dysmorphogenesis in patients with cystic fibrosis; and also the article contains justification for the connection between the formation of severe fibrosis of the lungs and liver and the presence of clinical and genetic markers of connective tissue dysplasia. The author assumes that the clinical and genetic polymorphisms of connective tissue influence the course of cystic fibrosis, formation of bronchiectasis, interstitial pneumofibrosis, cystic fibrosis dysplasia, liver fibrosis and cirrhosis.
EXPERIENCE IN APPLYING EDUCATIONAL PROGRAM FOR PEDIATRICIANS ON EMERGENCY CARE FOR CHILDREN USING MOBILE SIMULATION EQUIPMENT
Authors: Sadykova D. I. , Khasanov R. Sh. , Yusupova N. Z. , Belousova M. V. , Mikhaylova Т. V. , Safina L. Z. , Zakirov I. I. , Maryanina Yu. V.
Published: November 2018

The article describes the experience of implementing the “Emergency pediatrics” educational program with the use of simulation training methods, mobile simulation equipment, and distance educational technologies. The program is aimed at improving the doctors’ professional competence in emergency medical care for children. This format of the training helps to train the largest number of doctors in accordance with the international standards for emergency medical care on-the-job. The educational program makes it possible to assess the level of initial and final knowledge, to monitor professional skills, to determine the degree of the doctor’s readiness for emergency medical care for children. Based on the results of the incoming test control and assessment of basic cardiopulmonary resuscitation skills, we can conclude that the pediatricians have insufficient theoretical and practical skills of emergency care. As a promising direction, we plan to create a Register for sudden cardiac arrest, the Register of survival after sudden cardiac arrest in children at hospital and outside the hospital, which improve the quality of emergency and urgent care for children.
FREQUENCY AND OUTCOME OF RETINOPATHY IN PROFOUNDLY PRETERM NEWBORNS RECEIVING SPECIALIZED MEDICAL CARE
Authors: Shilova N. A. , Kharlamova N. V. , Fisyuk Yu. A. , Chasha T. V. , Churakova E. V. , Mezhinsky S. S.
Published: November 2018

Objective. To determine frequency of retinopathy cases in profoundly preterm newborns treated at Gorodkov Ivanovo Scientific Research Institute of Maternity and Childhood in 2016-2017, as well as to evaluate impact of the risk factors on disease severity in the conditions of specialized medical care. We examined 344 profoundly preterm newborns with gestational age of less than 32 weeks. 83 children (24.1%) were diagnosed with retinopathy of preterm newborns. A high quality of medical care was proved by a low percentage of children with severe forms of retinopathy in preterm newborns and absence of blindness in the children. A low gestational age, low Apgar score at the end of the first minute of life and traditional artificial lung ventilation are the most significant factors of severe retinopathy of preterm newborns.
FUNCTIONAL CONDITION OF THE CARDIOVASCULAR SYSTEM IN CHILDREN WITH TYPE 1 DIABETES DEPENDING ON THE LEVEL OF GLYCEMIA
Authors: Alimova I. L. , Demyanenko A. N.
Published: November 2018

Purpose of the study: to determine main parameters of the heart rhythm in children with type 1 diabetes, depending on the night level of glycemia. We performed bifunctional monitoring of glycemia and ECG in 50 patients with type 1 diabetes from 10 to 17 years. Depending on the glycemic parameters summarized in all patients we divided 3 groups: Group 1 (n=11) – sites of hypoglycemia (≤3.9 mmol/l), Group 2 (n=35) – optimal level of glycemia (4.0-9.0 mmol/l) and Group 3 (n=45) – sites of hyperglycemia (> 9 mmol/l). According to the results of glycemic monitoring, 96% of children do not have glycemic target marks at night and 20% of patients have asymptomatic night hypoglycemia. When analyzing the parameters of Holter ECG monitoring, the greatest value of heart rate, duration of the QTc interval, as well as atrial ectopic activity were often recorded during periods of hypoglycemia. Hyperglycemia also causes pathologic elongation of the ventricular electric systole and a greater number of ventricular extrasystoles. Thus, night hypo- and hyperglycemia in children and adolescents with type 1 diabetes leads to an extension of the QTc interval, an increase in the number of extrasystoles with the highest severity and frequency in hypoglycemia. We noted a high level of functioning of the sympathetic department of the autonomic nervous system and the central contour of heart rhythm regulation in children and adolescents with type 1 diabetes mellitus in hypoglycemia.