bluuebunny/crossref_metadata_2025 huggingface dataset:
Morente-Lorca, Lorca-Morente
Authors: Ossa Martínez Marco Antonio de la
Published: January 2022

In this paper we will focus on Morente-Lorca, the explicit recording that Enrique dedicated in 1998 to Fuente Vaqueros on the centenary of his birth. Produced by La Barbería del Sur under the artistic direction of the cantaor and arranged in two sections by Giorgi Petkov and Giorgi Krassimirov, it was structured in 14 tracks. In a good number of them, Morente started from different poems and fragments of Lorca dramas (So after five years, Doña Rosita la soltera, Yerma, Poeta en Nueva York, Poema del cante jondo and Diwán del Tamarit) that were put to music by Juan Manuel Cañizares, Juan Carlos Romero and by himself (he also took letters from San Juan de la Cruz and Francisco García Lorca).

Among them, “Campanas por el poeta” stands out, a song recorded live by the engineer José Ángel Ruiz in the Plaza de la Catedral in Barcelona at the 1998 Mercè Festival. In addition to the live performance, they also added the sound of the bells of the city of Granada collected from the Plaza de San Nicolás del Albaicín at 5 in the morning. They also picked up other echoes of the dawn atmosphere of the city of the Alhambra.

En este artículo nos centraremos en Morente-Lorca, la explícita grabación que el del Albaicín dedicó en 1998 al de Fuente Vaqueros en el centenario de su nacimiento. Producida por La Barbería del Sur bajo la dirección artística del cantaor y con arreglos en dos secciones de Giorgi Petkov y Giorgi Krassimirov, se estructuró en catorce cortes. En varios de ellos, Enrique partió de distintos poemas y fragmentos de dramas lorquianos (Así que pasen cinco años, Doña Rosita la soltera, Yerma, Poeta en Nueva York, Poema del cante jondo y Diwán del Tamarit) que fueron puestos en música por Juan Manuel Cañizares, Juan Carlos Romero y por él mismo (también tomó letras de san Juan de la Cruz y Francisco García Lorca).Entre ellos, sobresale “Campanas por el poeta”, tema grabado en vivo por el ingeniero José Ángel Ruiz en la plaza de la Catedral de Barcelona en las Fiestas de la Mercè de 1998. Además de la interpretación en vivo, también añadieron el sonido de las campanas de la ciudad de Granada recogido desde la plaza de san Nicolás del Albaicín a las cinco de la mañana. Del mismo modo, tomaron otros ecos del ambiente del amanecer de la ciudad de la Alhambra.
Jesús Arias y el universo Morente
Authors: Chicharro Martínez Irene
Published: January 2022

El presente artículo aborda a grandes rasgos la participación de Jesús Arias Solana (1963-2015) en el proyecto Omega de Enrique Morente. Músico, poeta y periodista, Arias es una de las personalidades clave en el panorama cultural de Granada de las últimas décadas, ya que, entre otras aportaciones, fue uno de los precursores del género musical punk en dicha ciudad y parte esencial para conocer la crítica musical en la prensa granadina de esos años. Jesús Arias, Lagartija Nick y Enrique Morente lograron con el proyecto Omega un espacio de interdisciplinariedad y heterodoxia dentro del mundo del rock y el flamenco.
ARTE Y EDUCACIÓN ARTÍSTICA
Authors: Álvarez García Francisco José
Published: January 2022

El presente artículo trata de, a través de una importante revisión bibliográfica, realizar una reflexión actual sobre los conceptos de arte y educación artística, profundizando en los axiomas de la creatividad como motor didáctico y la interdisciplinariedad de los lenguajes artísticos en el contexto educativo.

Partiendo de la idea de que las artes y por ende la educación artística son conocimiento, se incide en conceptos como la educación “del” arte (o “en” arte), la educación “para” el arte (para su producción y comprensión) o la propia “educación artística” (utilizando el resultado y ejecución como elemento transversal de enseñanza-aprendizaje).

Por otra parte, es tratada la dimensión trasversal de la propia educación artística a través de reflexiones concretas que invitan a acercarse al proceso creativo no como un elemento aislado, sino perteneciente a un conjunto de ítems que enriquecen el propio proceso de enseñanza-aprendizaje.
Vie musicale et contexte culturel de Sherbrooke (1940-1953)
Authors: Sirois Antoine
Published: January 2022

Les Canadiens français, qui ont colonisé les Cantons de l’Est depuis 1871, forment les quatre cinquièmes de la population sherbrookoise en 1941. Grâce au dynamisme de leurs institutions scolaires, de leurs organismes voués à la musique, au théâtre, aux arts visuels et aux lettres, grâce à une solide infrastructure pour les diverses prestations, ils ont pu, dans une collaboration et une pacifique compétition avec leurs concitoyens anglophones, parfaire leur développement culturel, particulièrement remarquable en musique. Dans les années 1940-1950, toute une jeune génération se prépare à participer et à apporter une contribution importante à la révolution des années soixante, localement et à l’extérieur.
La formation musicale de Serge Garant à Sherbrooke (1941-1951)
Authors: Lefebvre Marie-Thérèse
Published: January 2022

Recherche sur l’apprentissage musical du compositeur québécois Serge Garant durant sa jeunesse à Sherbrooke entre 1941 et 1951. L’auteure étudie l’importance du milieu familial et le rôle de trois musiciens de la région, Marcel Marcotte, Mimi Shea et Harry Long, dans la formation de compositeur avant son départ pour Paris.
Le chantre et la société paroissiale du Québec au XIXe siècle : la musique du lutrin et son temps
Authors: Pinson Jean-Pierre
Published: January 2022

Dans cet article, l’auteur cherche à dresser une première synthèse de la vie musicale dans les églises paroissiales au Québec durant le XIXesiècle, en prenant pour toile de fond la société paroissiale alors en plein développement. Ce premier exercice de synthèse s’appuie essentiellement sur les archives et les monographies locales, sources qui n’ont pas encore été systématiquement exploitées et traitées. En prenant comme figure centrale et emblématique le maître chantre, représentant de la tradition populaire, cet article cherche à ébaucher une histoire des rapports entre la société québécoise et la musique liturgique, histoire confrontée au courant international de la restauration liturgique et grégorienne, et perméable aux influences de la musique non liturgique, voire profane, alors en vogue.
La musique actuelle au Québec : enjeux et perspectives méthodologiques d’une analyse génétique
Authors: Stévance Sophie
Published: January 2022

La présente recherche se range du côté des approches analytiques du processus créatif visant une caractérisation stylistique de la musique actuelle francophone québécoise en centrant notre point de vue sur la manière dont ce courant musical utilise l’improvisation. Reposant plus particulièrement sur les stratégies « comprovisationnelles » à l’origine du disque Phénix (2008) du trio actualiste Les Poules, notre objectif est de mieux comprendre ce processus créateur. À partir d’approches permettant de retracer les états successifs des éléments musicaux (critique génétique, enquêtes ethnographiques, recherche-création en musique), il s’agit d’observer, grâce notamment à des modélisations, les constantes et les variantes dans les opérations d’écriture entre les divers paradigmes qui constituent Phénix (versions initiale, composée et performée). Sans toutefois épuiser les questions que soulève ce type de production, un contexte générant des collaborations entre chercheurs et créateurs a permis d’aller plus loin dans l’application de l’analyse génétique à la création musicale : en faisant apparaître les influences réciproques de la recherche sur la création que l’on peut difficilement passer sous silence.
A multi-center, cross-sectional study on the prevalence of facial dermatoses induced by mask use in the general public during the COVID-19 pandemic
Authors: Kaur Tanreet , Kaur Simplepreet
Published: January 2022

Background: The use of face masks and coverings has been recommended in public settings to minimize the risk of the transmission of coronavirus. The rampant surge in the use of masks for a prolonged duration has resulted in various facial dermatoses. Materials and Methods: The present study was an outpatient, multicentric, observational survey conducted over the period of one year. A total of 350 patients were enrolled. A structured questionnaire was employed to collect data identifying adverse skin reactions that had occurred in the area covered by a face mask. Results: Most of the facial dermatoses were observed in the urban population (78.85%). Maskne was the most common facial dermatosis, detected in 62% of the participants, followed by hypopigmentation (11.42%), hyperpigmentation (8.28%), contact dermatitis (5.42%), non-specific erythema (4.28%), desquamation (3.71%), urticaria (2.57%), and cheilitis (2.28%). The mean duration of mask use was 5.76 hours. A majority of the participants reported maskne in the U zone (both on the cheeks and the chin area) of the face (34%), followed by isolated involvement of the chin (26%), cheeks (20%), mandible region (14%), and bridge of the nose (6%). Conclusion: The use of face masks for extended hours without adequate precautions causes various cutaneous adverse effects. Thus, it is important to identify the risk factors precipitating mask-related facial dermatoses.
Urticarial eruption in COVID-19-positive children: A report of two cases
Authors: Ganjoo Shikhar , Vasani Resham
Published: January 2022

Recent literature has reported a variety of dermatological manifestations in children and adults associated with COVID-19. Herein, we report urticarial eruptions in two COVID-19-positive children. In the first case, urticaria with angioedema preceded a febrile episode and only partially responded to conventional doses of antihistamines. In the second case, urticaria followed the appearance of fever and upper respiratory symptoms. Both cases recovered completely within two weeks of diagnosis. These cases demonstrate that urticaria and angioedema, precedent or following a febrile illness, with or without respiratory symptoms, may be a presenting symptom of COVID-19 infection in children. A high index of suspicion in such cases helps the early administration of treatment and isolation of the patients to limit the spread of the virus.
Lupus vulgaris mimicking cutaneous leishmaniasis: A case report
Authors: Bin Rubaian Nouf Faihan , Alzamami Haya Fahad , Alhosawi Gadah Abdulatif , Almuhaish Leena Abdulrahman
Published: January 2022

Lupus vulgaris (LV) is a progressive, chronic form of cutaneous tuberculosis (CTB). The head and neck regions are the most commonly affected sites, followed by the arms and legs. Occurring in unusual sites may pose diagnostic difficulties. Herein, we report a case of LV present on the dorsal aspect of the right hand in a twenty-year-old Saudi male. It was misdiagnosed as leishmaniasis as the patient lived in an area in which it was endemic, and was treated accordingly with no benefit. A skin punch biopsy was taken and the diagnosis of LV was confirmed. The lesion responded well to anti-tubercular therapy (ATT), yet healed with atrophic scarring. Although rare, clinicians must be aware of the importance of considering CTB as an important differential, as misdiagnosis or delayed diagnosis of this entity may eventually cause prolonged morbidity.
SAPHO syndrome associated with a digestive disorder in a ten-year-old girl: Diagnostic difficulties
Authors: Dégboé Bérénice , Nouhoumon Gloria , Nguessie Christabelle , Akpadjan Fabrice , Agbéssi Nadège , Koudoukpo Christiane , Zomalheto Zavier , Sèhonou Jean , Adégbidi Hugues , Atadokpèdé Félix
Published: January 2022

SAPHO syndrome (acronym for synovitis, acne, pustulosis, hyperostosis, osteitis) is a rare dermato-rheumatic entity usually observed in young adults. The clinical manifestations are proteinaceous and without specificity at the origin of inflammatory diseases of the intestine. Our clinical case is that of a ten-year-old girl who presented with chronic and recurrent osteomyelitis of the pelvic limbs on a febrile background, followed by persistent and recurrent pustular lesions. During the same period, because of an acute abdominal pain syndrome accompanied by fever, a biological inflammatory syndrome, and predominantly neutrophilic hyperleukocytosis, laparotomy was performed and no lesions were found. She subsequently presented with intermittent and recurrent spasmodic abdominal pain. In view of these various symptoms, a multidisciplinary consultation concluded that the patient had SAPHO syndrome associated with a digestive disorder, possibly Crohn’s disease. Our clinical case illustrates the diagnostic difficulties of SAPHO syndrome.
Superficial epidermolytic ichthyosis: A rare disorder with the unusual absence of blistering
Authors: Rana Ashwani , Mehta Prajul
Published: January 2022

Superficial epidermolytic ichthyosis (SEI), formerly known as ichthyosis bullosa of Siemens (IBS), is an extremely rare keratinization disorder with superficial peeling, with an estimated prevalence of 1:500,000, caused by a variety of mutations in the keratin 2E gene. The clinical features include hyperkeratosis and blistering, but these are milder than in epidermolytic hyperkeratosis. The treatment is symptomatic and involves keratolytics and emollients. Herein, we report a case of SEI with the unusual absence of spontaneous blistering.
Sézary syndrome preceded by mycosis fungoides and complicated by tumor lysis syndrome and macrophage activation syndrome
Authors: Abdelmouttalib Asmae , Elghtaibi Fatima Zahra , Sialiti Sanae , Senouci Karima
Published: January 2022

Sir, Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common malignancies of cutaneous T-cell lymphoma [1]. Herein, we report a case of SS complicated by tumor lysis syndrome and macrophage activation syndrome. A 54-year-old patient, followed since October 2017 for mycosis fungoides and undergoing various treatments (PUVA therapy, methotrexate, chlorambucil + prednisone), presented with an aggravation of lesions toward extensive and intensely pruritic. A clinical examination revealed dry erythroderma, scratch marks, wart plaques, an accentuation of frontal wrinkles and nasolabial folds (leonine facies), palmoplantar fissuring keratoderma, xanthopachyonychia of all nails, and a carapace-like appearance of the scalp (Figs. 1 – 3). Generalized lymphadenopathy, hepatomegaly, and a state of anasarca-type edema caused by hypoalbuminemia were also found. A skin biopsy revealed lymphoproliferation of CD4+ T-cells and an aberrant loss of pan-T antigens. The CD4-to-CD8 ratio was at 48.5% and Sézary cells were 6960 (absolute value). A lymph node biopsy showed a dense infiltration of Sézary cells. A PET scan revealed hypermetabolism in the entire skin and at the lymph node level. Tumor lysis syndrome was evident, with high levels of blood uric acid (at 182 mg/L), elevated LDH (at 924 U/L), and functional kidney failure. Macrophage activation syndrome was also present, with fever, anemia and thrombocytopenia, liver cytolysis, hypertriglyceridemia, and hyperferritinemia. The patient received an albumin infusion, oral corticosteroid therapy to treat the syndrome, and rasburicase for hyperuremia. Despite this, the patient died before multiagent chemotherapy could have been started. On rare occasions, SS may be preceded by a prior history of classic MF. The International Society for Cutaneous Lymphomas (ISCL) recommends that such cases be designated “SS preceded by MF” [2]. Traditionally, SS is defined as a leukemic form of CTCL associated with erythroderma. Sézary cells are a population of large lymphocytes in the peripheral blood, with grooved and lobulated nuclei, in the case of SS, numbering 1000 cells/mL or more [2]. The histopathologic findings in the skin often resemble those observed in MF, with less prominent epidermotropism. As in MF, immunohistochemical studies showing a CD4 predominance and loss of pan-T-cell markers may be helpful. Lymph node involvement is characterized by the complete effacement of the nodal architecture by the infiltrating Sézary cells (2). The poor prognostic factors in Sézary syndrome include an advanced stage of the disease, an older age at onset, and large cell transformation [3]. While high response rates may be achieved with systemic chemotherapy, they are frequently short-lived and associated with significant toxicities [2]. The management of SS is complicated and requires multidisciplinary collaboration between dermatologists, hematologists, biologists, and reanimators.
Recurrent herpes zoster with IgD deposits, multinucleated keratinocytes and overexpression of galectin and glypican 3 in a patient with SARS-COVID-19 infection
Authors: Abreu Velez Ana Maria , Thomason Amanda Bortle , Jackson Billie L. , Howard Michael S.
Published: January 2022

The novel coronavirus disease (COVID-19) that currently plagues the world and caused by SARS-CoV-2, has spread internationally since late 2019. The dermatologic manifestations of this virus are currently being identified. We describe a 73-year-old Caucasian female who presented to many physicians for recurrent Herpes zoster episodes that persisted, despite treatment with multiple antiviral medications. The patient was diagnosed with COVID-19 before an onset of vesicular pustular lesions. The clinical diagnoses were recurrent herpes zoster and recurrent varicella. A skin biopsy was obtained and stained with hematoxylin and eosin to confirm a diagnosis. Immunohistochemical stains for Ki-67, Phospho-Histone H3, galectin 3, glypican and IgD were positive in multinucleated cells of the skin, where the viral lesions were detected. Recidivated herpes zoster and varicella are currently being clinically associated with COVID- 19; the abnormal immune response in patients with COVID-19 may be due to the overexpression of molecules that facilitate the outbreak of these viruses.
Et sted å starte: Geografiske utforskninger av litteratur
Authors: Samoilow Tatjana Kielland
Published: January 2022

Artikkelen tar form som en refleksjon over et utprøvende undervisningsopplegg med studenter i norskdidaktikk, høsten 2020. Med utgangspunkt i teorifeltet litterære geografier brukte vi geografi som analytisk linse i arbeidet med den svenske barneromanen Mördarens apa av Jakob Wegelius (2014). Studentene kartla romanens geografiske steder på et kart i Padlet, de analyserte de visuelle kartene i innsidepermene og reflekterte over sentrale handlingssteder i romanen. Utprøvingen indikerer at denne analytiske tilnærmingen hjalp studentene med å lese analytisk og stimulerte til kritiske refleksjoner. Likevel må det arbeides videre med å stimulere til nærlesing. Undervisningssekvensen er en del av en serie geografiske utprøvinger med det formålet å utvikle en spatial litteraturdidaktikk. Denne didaktikken skal svare på en utfordring i den nye læreplanen, LK20, nemlig: Hvordan kan vi utvikle kritisk lesing gjennom utforskende og tverrfaglig arbeid med skjønnlitteratur?
Genome-wide identification and expression analysis of the cucumber PYL gene family
Authors: Zhang Zeyu , Luo Shilei , Liu Zeci , Wan Zilong , Gao Xueqin , Qiao Yali , Yu Jihua , Zhang Guobin
Published: January 2022

Abscisic acid (ABA) is a very important hormone in plants. It regulates growth and development of plants and plays an important role in biotic and abiotic stresses. The Pyrabactin resistance 1-like (PYR/PYL) proteins play a central role in ABA signal transduction pathways. The working system of PYL genes in cucumber, an important economical vegetable (Cucumis sativus L.), has not been fully studied yet. Through bioinformatics, a total of 14 individual PYL genes were identified in Chinese long ‘9930’ cucumber. Fourteen PYL genes were distributed on six chromosomes of cucumber, and their encoded proteins predicted to be distributed in cytoplasm and nucleus. Based on the phylogenetic analysis, the PYL genes of cucumber, Arabidopsis, rice, apple, Brachypodium distachyon and soybeancould be classified into three groups. Genetic structures and conserved domains analysis revealed that CsPYL genes in the same group have similar exons and conserved domains. By predicting cis-elements in the promoters, we found that all CsPYL members contained hormone and stress-related elements. Additionally, the expression patterns of CsPYL genes were specific in tissues. Finally, we further examined the expression of 14 CsPYL genes under ABA, PEG, salt stress. The qRT-PCR results showed that most PYL gene expression levels were up-regulated. Furthermore, with different treatments about 3h, the relative expression of PYL8 was up-regulated and more than 20 times higher than 0h. It indicated that this gene may play an important role in abiotic stress.
Spatiotemporal variations in length-weight relationship, growth pattern and condition factor of Periophthalmus variabilis Eggert, 1935 in Vietnamese Mekong Delta
Authors: Dinh Quang Minh , Nguyen Ton Huu Duc , Nguyen Tien Thi Kieu , Tran Giang Van , Truong Ngon Trong
Published: January 2022

Length-weight relationship (LWR), growth pattern and condition factor (CF) play a vital role in fish resource evaluation and management but data on this is limited for Periophthalmus variabilis. This is an amphibious fish that lives in the mudflats of the mangrove forests in the Western Pacific regions, including the Vietnamese Mekong Delta (VMD). This paper contributes to the understanding of the LWR, growth pattern and CF of P. variabilis. Fish specimens were collected by hand at four sites in the VMD from April 2020 to March 2021. The analysis of 495 individual fish (259 females and 236 males) showed that fish weight could be estimated from a given fish length due to high determination values (r2 = 0.70 − 0.97). Dusky-gilled mudskippers of the VMD exhibited positive allometry, as indicated by their larger than 3 b value (b = 3.094 ± 0.045, p = 0.04). However, the growth pattern of the mudskipper between the sex and maturation stage (immature versus mature) showed isometry. These fish displayed positive allometry in the dry season (b = 3.138 ± 0.065) (>3, p = 0.04) but isometry in the wet season (b = 3.058 ± 0.061) (≈3, p = 0.34). Fish growth ranged from isometry to positive allometry and varied by site (b = 2.850 ± 0.103–3.370 ± 0.114) and month (b = 2.668 ± 0.184–3.588 ± 0.299) based on the b value. The CF of P. variabilis was not affected by sex (p = 0.29), body size (p = 0.64) or season (p = 0.43), but was affected by site (p = 0.01) and month (p = 0.01). The CF of this species (1.05 ± 0.02) was higher than 1 (p < 0.001), indicating that the fish adapted well to their habitat.
Qualitative Evaluation of Platelet Concentrates Prepared with Different Methods
Authors: Varshashree . , Das Subhashis , Prabhakar K
Published: January 2022

Introduction: One of the most important responsibility of Blood Bank is to ensure uninterrupted supply of quality blood products, namely Platelet Concentrate (PC), which are in high demand particularly during pandemic. In India, PCs are of three types prepared by different methods like Platelet Rich Plasma-Platelet Concentrate (PRP-PC), Buffy Coat Platelet Concentrates (BC- PC), and Single Donor Platelets (SDP) units. Hence, establishing optimum quality standards across all the three types of PC remains a challenge in order to maximum benefit to recipients. Aim: To assess and compare the quality parameters of platelet concentrate prepared by PRP-PC, BC-PC and apheresis methods (SDP). Materials and Methods: This laboratory based observational study was conducted at rural, tertiary care, postgraduate, teaching hospital located at South India from December 2018 to November 2019. A total of 156 PCs were studied with 52 units belonging to PRP method, 52 units BC-PC method and the remaining were 52 units of SDP prepared by apheresis method. Quality parameters include volume, pH, swirling, White Blood Cell (WBC) count/bag, platelet count/bag and platelet indices. Platelet indices include Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), and Platelet Large Cell Ratio (PLCR). Arterial Blood Gas (ABG) analysis was also done to assess (pH, partial pressure of Carbon Dioxide (pCO2), plasma bicarbonate (pHCO3-)). The p-value less than 0.05 were considered statistically significant. Statistical Package for the Social Sciences (SPSS) software version 23.0 used for statistical analysis. Results: All the 156 PC units were analysed as per the Director General of Health Services (DGHS) India, criteria. Among the 156 platelet concentrates scored as per DGHS criteria, a score of 5 was obtained for 34.61% [18/52], 30.76 [16/52] and 11.5% [6/52] SDP, BC-PC and PRP-PC units, respectively. All the PC units were sterile and Red Blood Cell (RBC) contamination was within acceptable limits. Conclusion: In this study, quality parameters of SDP was better than BC-PC and PRP-PC but with improvement and more standardisation of procedures and storage, BC-PC units can give a yield similar to that of SDP units.
Immunohistochemical Expression of Vascular Endothelial Growth Factor in Ovarian Surface Epithelial Neoplasms and its Association with Histological Type, Grade, Clinical Stage and Tumour Metastasis
Authors: Kar Asaranti , Das Debasmita , Nayak Bhagyalaxmi , Bhuyan Pallavi , Panda Sasmita , Kar Tushar
Published: January 2022

Introduction: Ovarian carcinoma is one of the most common gynaecologic cancers and remains the leading cause of death as the patients are diagnosed at the advanced stage of the disease. Vascular Endothelial Growth Factor (VEGF), a promoter of angiogenesis, participates in multiple mechanisms to promote ovarian cancer cell growth, angiopoiesis and distant metastasis. So, it is a promising target for antiangiogenic therapy in management and downstaging of ovarian cancer. Aim: To evaluate the immunohistochemical expression of VEGF in different surface epithelial neoplasms of ovary and compare it with histological type, grade and stage in malignant cases. Materials and Methods: This was an observational cross-sectional study conducted from August 2018 to January 2020. Total 50 consecutive cases of surface epithelial ovarian neoplasms received in Pathology Department of Srirama Chandra Bhanja (SCB) Medical College, Cuttack were examined for expression of VEGF by Immunohistochemistry (IHC). Data was examined to find association of VEGF expression with demographic profile, grade, stage and were analysed statistically using Statistical Package for the Social Sciences (SPSS) software version 21.0. Statistical significance was tested by using Pearson’s chi-square test. The p<0.05 was considered significant. Results: Total 50 cases of ovarian surface epithelial neoplasms of different types and grade were included in the study. A 42 of the 50 cases (84%) showed VEGF expression. Out of the 42 positive cases, 18 were high VEGF expressors and 24 were low VEGF expressors. The VEGF expression was significantly higher in carcinomas as compared to benign and borderline neoplasms and also in high grade malignancies in comparison to low grade (p≤0.001). Conclusion: The study shows that the differential expression of VEGF in different ovarian epithelial neoplasms which can be a diagnostic and prognostic tool and can be applied as a VEGF targeted therapy in certain group of patients.
Histomorphological Study of Urinary Bladder Biopsies- A Retrospective Study in a Tertiary Care Centre, Kerala, India
Authors: Preethamol S , Prasanth PS
Published: January 2022

Introduction: Urinary bladder diseases are quite frequent in clinical practices. Both non neoplastic and neoplastic lesions are quite common. Bladder malignancies are on an increasing incidence and are considered as an important cause of cancer related morbidity and mortality. To provide accurate diagnosis and treatment histopathology remains as the gold standard investigation. Aim: To study the histomorphology of lesions of bladder obtained through Trans Urethral Resection of Bladder Tumour (TURBT) and cystoscopic biopsies. Materials and Methods: The present study was a five years descriptive retrospective study conducted over a period of six months starting from July 2020 to December 2020 and data were collected from records for the period of January 2015 to December 2019 carried out in the Department of Pathology, Government Medical College, Trivandrum, Kerala, India. Record of all patients who visited to Urology Outpatient Department (OPD) with lower urinary tract symptoms and obstructive bladder symptoms and subjected to cystoscopy were included in study. The detailed clinico-histomorphological features of all biopsies were studied using World Health Organization (WHO)/ International Society of Urologic Pathologists (ISUP) 2016 histological grading and Tumour (T), Nodes (N), and Metastasis (M) (TNM) staging were used in classifying the bladder tumours. Results: The data for the present study was collected over a period of five years; during which a total of 742 lesions were histopathologically evaluated. A total of 688 cases (92.72%) were neoplastic, 46 cases (6.19%) were diagnosed as non neoplastic and 8 cases were (1.07%) were metastatic malignancy. A total of 646 cases (87.06%) were males. Most common affected age group was 61-80 years. Haematuria was the most common clinical presentation. A 332 cases (48.25%) were of non invasive papillary urothelial neoplasm low grade. Conclusion: Lesions of urinary bladder are heterogenous in nature. Detailed awareness regarding the various histological features of these lesions, their neoplastic potential, risk of recurrence and possible pitfalls can help pathologists for accurate diagnosis. The study also emphasised on inclusion of smooth muscle in the biopsy for accurate grading and staging in bladder tumours.
MCM2 Expression in Different Molecular Subtypes of Epithelial Breast Cancers and its Association with Clinicopathological Parameters and Ki-67 Expression
Authors: Mandal Meghadipa , Chowdhury Anadi Roy , Mukhopadhyay Susmita
Published: January 2022

Introduction: Breast cancer is one of the most common malignancies, with few subtypes having a more aggressive outcome and resistance to conventional therapies, Triple Negative Breast Cancers (TNBCs) being one such variant. The Ki-67 lacks reproducibility and a standardised cut-off. MCM2 (Minichromosome Maintenance 2) has role in DNA repair and replication and its role as alternate marker for prognosis has been studied in this case. Aim: To study MCM2 expression with respect to histologic grade, stage, nodal status and molecular subtypes of breast carcinoma. Also, to look for any correlation between Ki-67 and MCM2 expressions. Materials and Methods: A cross-sectional, observational study conducted on a group of 20 patients who underwent mastectomy in a Tertiary Care Centre, R.G. Kar Medical College and Hospital, Kolkata, West Bengal, India, for a total duration of six months. Histologic grading, staging, nodal status was evaluated from Haematoxylin and Eosin (H&E) stained sections. Formalin-Fixed Paraffin-Embedded (FFPE) blocks suitable for Immunohistochemistry (IHC) were selected and MCM2, Estrogen Receptor (ER), Human Epidermal Growth Factor Receptor 2 (HER2), Progesterone Receptor (PR)/neu and Ki-67 were performed. Scores given based on visual examination under light microscope. Analysis was done using IBM Statistical Package for the Social Sciences (SPSS) version 25.0 software. Results: Most of the subjects belonged to 41-55 years age group. Statistical significance was seen between high MCM2 and Ki- 67 expressions (p-value=0.0171) and high histologic grade and TNBCs (p-value=0.009). High MCM2 and Ki-67 expressions also come with increased risk for advanced disease. High Ki-67 is also a risk predictor for lymph node positive cases. Positive correlation was seen between MCM2 and (R)= 0.4318. Conclusion: The MCM2 is a predictor for adverse outcomes in breast carcinoma cases. It may serve as an alternative to Ki-67 as a proliferation marker, to guide clinicians in treatment strategies. Its role as a therapeutic target in aggressive breast carcinomas may be evaluated with larger study population in the future.
Recurrent Cutaneous Adenoid Cystic Carcinoma of Forehead
Authors: Vijayaraghavan Ashi , Ramamoorthy Subhashini , Theresa Sylvia Mary , Srinivasamurthy Banushree C , Sinhasan Sankappa P
Published: January 2022

Adenoid Cystic Carcinoma (ACC) is a malignant tumour more commonly seen in salivary glands and rarely arises from the skin as adnexal tumour. Cutaneous ACC is a rare malignant adnexal tumour of eccrine origin. It has an indolent course and rarely metastasizes. Hereby, authors report a case of 48-year-old male with complaints of swelling on right forehead present for the past four years. Clinical diagnosis of infected sebaceous cyst was made and excised with simple excision. The swelling reappeared within 15 days of first surgery. The cytological examination of the swelling revealed abundant cellularity with predominantly cohesive clusters of monomorphic population of cells centered around eosinophilic hyaline globules suggestive of ACC. Retrieval of previous biopsy report revealed diagnosis of ACC reaching the margins of excision, the report of which was neither collected by either operating surgeon nor by the patient. Histopathological examination revealed classical cribriform pattern of arrangement of tumour cells with perineural infiltration by tumour cells. Immunohistochemistry further confirmed the diagnosis. The present case report brings out the importance of clearance of surgical margins in malignant tumours, including skin adnexal tumours. It also highlights the importance of histopathological examination of benign looking skin adnexal tumours.
Two – Warehouse Inventory System Model for Deteriorating Items Considering Partial Upstream Trade Credit Financing
Authors: Aliyu Z. H. , Sani B.
Published: January 2022

In this study, we developed an inventory system model under two – level trade credit where the supplier considers the retailer as credit risk but the retailer considers the customers as credit worthy. Therefore, the retailer is given a trade credit period on  proportion of the goods ordered whenever he/she pays for proportion of the goods immediately after delivery. In the same vein, the retailer passes the same grace to the customers but without attaching any condition as the customers are assumed credit worthy. This partial upstream trade credit is offered to reduce the risk of failure in payment on the business transaction especially that most retailers are involved in bulk orders. The relevant cost functions are determined and a numerical example is given. Sensitivity analysis was carried out to see the effect of changes in parameters on the optimal solution of the model.
Bioactive Building Blocks and Potential Pharmacological Perspectives of Green Coffee: A Review
Authors: Kundu Namrata , Pant Gaurav
Published: January 2022

Coffee is known to be one of the popular beverages today on the globe. Due to its easy availability and preparation, it is consumed by the population of almost all countries. This wonder crop was discovered in the 6th century in Ethiopia. Since then, people have also used various brewing methods to extract hundreds of the bioactive compounds present in these aromatic seeds. No doubt, excessive consumption of the same can be harmful too. As a functional food, coffee is known to have multiple health benefits. Coffee beans contain vitamins, minerals, caffeine, chlorogenic acid, and various other biologically active ingredients. This review briefly describes the major biologically active compounds present in these seeds – caffeine, trigonelline, diterpenes, and chlorogenic acid (CGA). It also aims to describe various bioactive activities such as antioxidant, antiproliferative, antibacterial, antiviral, etc., against variable hallmarks. Thus, explaining different pharmacological effects for the welfare of the human population.
Geospatial Distribution of Iron in Major Sugarcane Growing Soils of Sivagangai, Tamil Nadu, India
Authors: Chandrasekar K. , Prabhaharan J. , Mahendran P.  P. , Pandiyan P. Saravana , Gurusamy A. , Gnanamalar R. P. , Kannan P.
Published: January 2022

The present study was undertaken to assess the available DTPA iron status in the major sugarcane growing soils of Southern Sivangai district, Tamil Nadu, India. A total of 500 geo referenced surface (0-30 cm) were collected from five blocks viz., Kalaiyarkovil, Padamathur, Sivagangai, Thiruppachetty and Thiruppuvanam and analyzed for basic soil properties and available DTPA iron. Simple correlation was worked out to ascertain the degree of relationship between soil properties and available DTPA iron content of soil study area. The available DTPA iron in the entire sugarcane growing soils ranged from 2.95 to 5.79 mg kg-1, 2.11 to 4.31 mg kg-1, 3.49 to 5.59 mg kg-1, 1.99 to 5.66 mg kg-1 and 3.94 to 6.39 mg kg-1 in soil samples of Kalaiyarkovil, Padamathur, Sivagangai, Thiruppachetty and Thiruppuvanam respectively. In the soil samples from Kalaiyarkovil, Padamathur, Sivagangai, Thiruppachetty, and Thiruppuvanam, the results revealed that 52, 59, 55, 53, and 51 % of the soils were deficient in available iron and 33, 29, 35, 30 and 32 % of the soils were moderate in available iron, and 15, 12, 10,5 and 17 % of the soils were sufficient in available iron. As per the nutrient index study, the soils of study area recorded very low to low fertility rating for available iron and the mean nutrient index value (NIV) ranged from 1.42 to 1.64 in the soil of the study area. SOC and CEC were found to have a beneficial impact on iron availability, whereas EC and CaCO3 levels had a negative impact on DTPA iron availability.
A Novel Spectrophotometric Determination and Kinetic Study of Sulfamethoxazole in Pure and Tablet Formulation using 9-chloroacridine Reagent
Authors: Ahmed Alaa A. , Al-Sabha Theia’a N. , Al-Hyali Emad A. S.
Published: January 2022

A spectrophotometric method has been developed for analysis of Sulfamethoxazole (SMX) in pure and dosage forms. The method is based on the reaction of the SMX with 9-chloroacridine (9-CA) reagent in organic and acidic medium, to produce a yellow product having maximum absorption at 448 nm. Beer’s law was obeyed in the concentration range 1-30 μg.ml-1 with molar absorptivity of 1.63x104 L.mol-1.cm-1 with good detection and quantification limits. Accuracy (Average recovery %) and precision are 98.43% and 0.651, respectively. The proposed method was applied successfully for determination of Sulfamethoxazole in its commercial dosage form as tablet and agree well with the official method.

The equilibrium constant and the thermodynamic functions (ΔHo, ΔGº and ΔSº) of the  complex formation were estimated. The study revealed that the complex formation could occur spontaneously, the type of interacting forces between SMX and 9-CA are physical is nature and association increases the order of the studied systems.

The results of kinetic parameters indicated that, the reaction is pseudo first order with respect to SMX. The rate constant at various temperatures and the thermodynamic functions of activation were determined. Theoretical parameters were calculated by applying the semi-empirical Austin method (AM1). These parameters are helped to suggest reaction mechanism and supporting other results.
The Effect of Fat Emulsion Intralipid Infusion on Reproductive Outcome for Women with Unexplained First Trimester Habitual Abortion
Authors: Al Mohasseb Mahmoud Abd Alsattar , Goda Eltahera Mohsen
Published: January 2022

Objectives: To study the effect of the use of intralipid in management of women suffering from unexplained first trimester habitual abortion.

Methods: The study was a prospective cohort study, which conducted in Tanta university Hospital; Egypt. It included 93 women with history of two or more unexplained recurrent abortion in the first trimester. They were divided into three groups: group Ι received only intralipid, group II received low molecular weight heparin (LMWH) and low dose aspirin, and group III served as controls and received only saline as placebo. The patients were followed up until continuation of pregnancy into the second trimester. Occurrence of complication and pregnancy outcomes were evaluated.

Results: Ninety three women were included. After treatment, more pregnancy continued into the second trimester, more live births and less numbers of abortions in group A and B in comparison with group C (p=0.008, 0.008 and 0.035) respectively. Maternal and neonatal outcomes were comparable in all studied regimens.

Conclusions: Management of women with unexplained first trimester habitual abortion (before 14 weeks) with intralipid or LMWH with small dose of aspirin may increase the proportion of pregnancy continued into the second trimester, more live births and less numbers of abortions. However, LMWH is more superior to the intralipid but with more side effect.
Serological Changes of Monoclonal Antibody CAMA3C8 against Human Breast Cancer Cell Line
Authors: Muninathan N. , Ponnazhagan K. , Meghalatha T. S.
Published: January 2022

Background: Tumor associated antigen are glycoproteins and glycolipids expressed on the surface or in the cytoplasm of tumor cells. The antigenic components are shed from the tumor cells into the tissue culture medium or blood or other human body fluids like human milk.

Objective: In the present study, investigate the serological assay of the antigen recognized by CAMA3C8 in patients with carcinoma of the breast.

Methods: The study is desgriptive cross section study.The study was divited into four groups based on the expression of tumor associated antigen.

Results: In breast cancer CAMA3C8 levels were significantly increased in stage 4 when compared with stage 1 breast cancer cell line. 

Conclusion: In the present study, we conclude that significantly recognized CAMA3C8 defined antigens in breast cancer.
Estimation of Variations in the Erythrocyte Sedimentation Rate in COVID-19 Recovered Patients
Authors: Aravindan Manoj , Sinduja Palati , Priyadharshini R. , Meghashree V.
Published: January 2022

Background: A cluster of patients with pneumonia and severe acute respiratory syndrome developed in Wuhan, China in December 2019, and infection with a novel coronavirus virus called COVID -19 was later verified. Although fever and cough were the most common early signs and symptoms of COVID -19, extrapulmonary symptoms have also been reported. Many studies demonstrate that called COVID -19 swiftly progresses to acute respiratory distress syndrome and even multiple organ dysfunction.

Aim:The study aims to evaluate the erythrocyte sedimentation rate count in COVID -19 recovered individuals and compare it with healthy controls.

Materials & Methods: A cross-sectional pilot study in 5 healthy COVID -19 uninfected and 5   COVID -19 recovered individuals was conducted, the blood samples were collected and the erythrocyte sedimentation rate was calculated for each set of controls and samples. Statistical analysis was performed using SPSS software. An independent t-test was done to compare the results.

Results: The mean value of the control participants was found to be 8.08 ± 4.38 and the mean value of COVID -19 recovered patients was 20.60 ± 1.81. The difference in Erythrocyte Sedimentation Rate (ESR) values between control individuals and COVID -19 recovered patients was statistically significant with p value of less than 0.005.

Conclusion: Within the limitations of the study, we conclude that the COVID -19 recovered patients has higher ESR values compared to the healthy uninfected individuals.
Case Report on Cerebral Venous Sinus Thrombosis
Authors: Mujbaile Gaurav , Tembare Vaishali
Published: January 2022

Introduction: Cerebral venous sinus Thrombosis is the unusual cause of a stroke affecting both reproductively old and genetically or thrombotic risk factors (CVST). The superior sagittal sinus and the cross sinus are two most common places for thrombus formation. A 26-year-old Man was taken to the Acharya Vinoba Bhave Rural Hospital with a new-onset complex-partial convulsion with secondary generalization, headache, and emesis seven days before presentation. Later on he experienced headache which was acute in onset and continuous in nature which was associated with fever. Patient had 1 episode of seizers lasting for 3-4 mints. Which was associated with fall on ground. He complained about weakness in left upper limb.

The patient was then transferred to our care institution for definitive management. On arrival, the patient’s neurological examination was done and he reported a severe headache. MRI imaging performed at our institution. The patient was followed clinically, and no posttreatment imaging studies were performed. Following a 3-day hospital stay, the patient reported a significant reduction in headache severity and was discharged home.
Attitude and Views towards Mental Health among Dental Students
Authors: Sri Sangaraju Soumya , Priya A. Jothi , Devi R. Gayatri
Published: January 2022

Introduction: Stress can be a feeling of emotional or physical tension. It can come from any event or thought that can make us feel frustrated, angry, or nervous. Stress is your body's reaction to a challenge or demands.

Aim: The aim of the study is to assess attitude and views towards mental health and psychiatry among dental students.

Materials and Methods: Study Setting is prospective observational study.The advantages of this study was economical, easy to create, wide reach, and gathering larger data Quick Interpretation . It was approved by the scientific review Board Saveetha Dental college Chennai .Number of participants involved in this study are 138 college students .The responses from the google sheet were transferred into excel. Inferential statistics was done using Chi square test and exported to SPSS software, version 25

Results: From the survey conducted among dental students on mental health and psychiatry.Majority of dental students were female participants compared male participants.Interpretation was based on a p value less than 0.05, which was considered to be statistically significant.

Conclusion: The findings of the present study proves that the majority of dental students have awareness of attitudes and views of mental health .Among dental students, females are the major participants compared to males. In order to develop psychiatric and mental health services, public acceptance is necessary.
Pleomorphic Adenoma of Neck: Case Report
Authors: Shukla Deepankar , Bhola Nitin
Published: January 2022

Pleomorphic adenomas are benign tumour of the salivary glands that mostly affect the parotid gland. The tumor's "pleomorphic" form can be explained by its epithelial and connective tissue origins. Females between the ages of 30 and 50 are more likely to get the tumour. The tumour usually presents as asymptomatic swelling that progresses slowly. The majority of treatment is surgical removal of the tumour mass, with special attention paid to preserving the facial nerve. This is a case report of a 42-year-old female patient who had a pleomorphic adenoma of the submandibular gland. On the right side of the face, the patient had a slowly growing asymptomatic swelling. Pleomorphic adenoma is the commonest salivary gland tumor characterized by  diverse  histomorphological  features.  Early diagnosis and treatment plan entails thorough history taking, clinical examination, coupled with radiographic and histopathological findings.