bluuebunny/crossref_metadata_2025 huggingface dataset:
Revisión del modelo geometalúrgico para la estimación de recursos minerales en depósitos pórfido cupríferos
Authors: Ramos Armijos Nelson Jesús , Calderón Celis Julia Marilú
Published: August 2023

El modelo geometalúrgico es una herramienta que permite evaluar la variabilidad de los depósitos minerales desde el punto de vista geológico, de procesamiento y producción. Con ello es posible estimar el valor actual neto más realista y reducir significativamente el riesgo técnico-operacional que se presenta en las etapas de factibilidad de un proyecto minero. En la presente investigación se ha realizado una búsqueda exhaustiva sobre estudios enfocados a modelamiento geometalúrgico en depósitos pórfido cupríferos en los cuales se ha estimado y simulado como variables geometalúrgicas la ley de cobre total, cobre oxidado, elementos penalizantes, recuperación metalúrgica, índice de trabajo y de abrasión. A través de esta investigación se evidencia que al incorporar atributos geometalúrgicos en la estimación de recursos minerales es posible cuantificar de mejor forma la variabilidad espacial del depósito, prever aquellos minerales que interfieran en el tratamiento metalúrgico y valorar la probabilidad de cada destino para los bloques minerales en el procesamiento.
Modelo matemático para la recuperación de oro y zinc mediante el proceso de flotación a partir de minerales sulfurados de zinc marmatitico en la provincia de Casma – Ancash
Authors: Aramburú Rojas Vidal Sixto , Calderón de Alvarado Julia Marilú , Adama Navarro Aldo Joel , Ortiz Barreto Jorge Alberto , Gutiérrez Falcón Luís Santiago , Quispe Gallegos Luís Enrique
Published: August 2023

El presente estudio de investigación demuestra que es viable la recuperación de oro y zinc en minerales de zinc marmatitico con contenido de oro. Se analizó la recuperación de oro y zinc mediante diseños experimentales factoriales, utilizando los reactivos: CuSO4, AR-3418 y AR-1242 como variables independientes; el resto de las variables se mantuvieron constantes.

Como resultado de la investigación se obtuvo un modelo para la recuperación de oro y zinc, realizando el análisis del diseño factorial ajustado como se indica:

Recuperación de Au = 83.40+ 0.00600 CuSO4+ 0.110 AR-3418+ 0.035 AR-1242+ 0.000313 CuSO4*AR 3418+ 0.000275 CuSO4*AR-1242- 0.00800 AR-3418*AR-1242 - 0.000011 CuSO4*AR-3418*AR-1242.

Asimismo, la recuperación de Zn = 73.14 + 0.0100 CuSO4+ 0.132 AR-3418+ 0.051 AR-1242 + 0.000164 CuSO4*AR-3418 + 0.000131 CuSO4*AR-1242 - 0.00811 AR-3418*AR-1242 - 0.000004 CuSO4*AR-3418*AR-1242.
Impactos en la salud humana y ambiental generados por la actividad de construcción de edificios multifamiliares en la ciudad de Lima
Authors: Suárez Salinas Jesús , García Gamboa Carmen , Velasco Urdiales Miguel , Huiman Cruz Alberto
Published: August 2023

La construcción de edificios multifamiliares destaca como una de las principales actividades económicas de la ciudad de Lima, incluso ha sido considerada en la primera etapa de reactivación económica en plena pandemia del COVID-19 y a la fecha ha logrado alcanzar las expectativas previstas, sin embargo, son significativos los impactos resultantes de dicha actividad que generan daños al ambiente y la salud humana.Para el desarrollo de la investigación se consideró la revisión de fuentes de primer orden, principalmente tesis de universidades nacionales y extranjeras las cuales abordan la problemática de identificar los impactos más significativos al ambiente y la salud humana durante la construcción de edificios multifamiliares. La presente investigación es descriptiva, comparativa y aplicada; se desarrolla un enfoque cualitativo-cuantitativo, mediante el análisis de la matriz de Leopold modificada que permite alcanzar el objetivo de identificar las actividades del proceso constructivo que generan mayores impactos ambientales y la salud humana, siendo éstas: demolición, excavación y estructura casco (Chávez Vargas, 2014), con la finalidad de la proponer acciones de mitigación y control.
Los resultados obtenidos determinaron que las etapas de demolición, excavación y estructura casco son las que generan impactos negativos más significativos al ambiente, principalmente contaminación del aire por material particulado, gases y ruido ambiental, también contaminación del suelo por generación de residuos sólidos. Referente a los impactos negativos significativos a la salud humana además de las 3 etapas anteriormente mencionadas se obtuvo resultado que también durante los acabados se genera daño pudiendo resultar en enfermedades ocupacionales.
Análisis costo beneficio de la implementación de un sistema de gestión de seguridad y salud ocupacional basado en la productividad de la empresa Electrocons Ingenieros S.A
Authors: Malpartida Córdova Yeni Miriam
Published: August 2023

El objetivo de la presente investigación, se relaciona con la realización de un análisis costo-beneficio de la aplicación de método para colocar en marcha un Sistema de Gestión de Seguridad y Salud en el trabajo, con la intención de incrementar los índices de producción de la empresa Electrocons Ingenieros S.A., como herramienta para promover un ambiente de trabajo más seguro, lo cual permitirá que el trabajador detecte preventivamente, la presencia de accidentes laborales y lograr mejores resultados en los empleados, mediante la tipificación factores de riesgos en los que se encuentra expuesto el trabajador y generen accidentes laborales según la evolución de las actividades desarrolladas en la empresa Electrocons Ingenieros S.A. Esta investigación se basa en investigaciones realizadas por autores como Cortés Díaz (2018), Koontz et al. (2012), Organización Internacional del Trabajo (OIT, 2019), Muñoz Romero (2014) y Martínez Gómez (2015). Se basó en estudios no experimentales y tiene un diseño transversal y correlacional. La población era de 40 empleados, con una muestra de treinta y seis (36) empleados. Para la recogida de datos se utilizó la observación no estructurada, las notas y la memoria fotográfica tras visitar las instalaciones de Electrocons Ingenieros S.A., lo que reveló que el establecimiento de un Sistema de Gestión de Seguridad y Salud Ocupacional (SGSSO), lo cual influyó de forma positiva para obtener un valor añadido a la variable de productividad de la empresa Electrocons Ingenieros S.A.
Evidencia geoquímica y geocronológica del Batolito de Pataz entre los paralelos 8°10´S - 8°17´S
Authors: López Mogrovejo Willy , Yparraguirre Calderón José Andrés , Mayorga Rojas Jaime César
Published: August 2023

El Batolito de Pataz del Carbonífero (Missisipiano), datado entre los 329 – 347 Ma (Haeberlin et al., 2004), tiene aproximadamente 160 km de largo (N30°O) y un ancho de 2.5 a 5 Km actualmente reconocidos.  El intrusivo está constituido por más de una facies plutónica; una facies de granito – granodiorita y otra facies de tonalita - diorita, siendo la primera la más favorable para el emplazamiento y desarrollo de las vetas del tipo orogénico con contenido aurífero.

La zona de estudio se emplaza entre los paralelos 8°10´S a 8°17´S, entre las localidades de Llacuabamba y Tayabamba de la provincia de Pataz, Perú, los estudios realizados a los intrusivos aflorando en las inmediaciones de la localidad de Tayabamba habrían mostrado una similitud petrológica y geoquímica al Batolito de Pataz, la afinidad de todas las muestras hacia granitos de arco volcánico, así como una similitud en el ratio SiO2 vs Sm/Yb, hace presumir  una posible coetaneidad de los pulsos cristalinos (Mantle & Collins, 2008), esto ha sido corroborado con los resultados geocronológicos U-Pb obtenidos, los cuales colocan a los intrusivos de la zona de estudio entre los 333 – 335 Ma, afirmando con esto la continuidad del Batolito de Pataz hacia el Sur.
Modelo de vulnerabilidad al cambio climático por peligro de inundaciones para el cálculo del costo evitado Caso Sector El Piste, Ciudad de Calca, Cuzco
Authors: Montero Chirito Juan Carlos , Cabrera Carranza Carlos Francisco
Published: August 2023

Esta investigación estuvo basada en la determinación de un modelo de vulnerabilidad al cambio climático por peligro de inundaciones para el cálculo del costo evitado, cuya característica relevante es la importancia de la variable precipitación. El primer paso ha consistido en la elaboración del estado de arte sobre modelación de vulnerabilidad en la temática de inundaciones. Cuando se trata de modelar inundaciones, se plantea un problema que se origina esencialmente en tratar de simular, con expresiones discretas en el tiempo y el espacio, un progreso que ocurre en la naturaleza a una escala progresivamente mucho menor. La última etapa de la investigación consistió en la corrida del modelo, comparando los valores numéricos con las medidas de control a implementarse, obteniéndose mapas con diversos periodos de retorno ante inundaciones. La principal conclusión es que la modelación ante inundaciones está en función del área de estudio y de las variables meteorológicas, y reducir los niveles de incertidumbre sigue siendo el reto principal, y más aún si lo orientamos al cálculo del costo evitado por inundaciones.
TRENDS OF THE LIGHT OIL PRODUCTS MARKET OF UKRAINE AND PROSPECTS OF ENERGY SECURITY IN THIS FIELD
Authors:   Lviv Polytechnic National University, Kuzo N.Je. , Kosar N.S. ,   Lviv Polytechnic National University
Published: August 2023

The market of light oil products is decisive for every country, significantly influencing all sectors of the economy and the standard of living of citizens. It was investigated that in 2020, compared to 2019, sales volumes of all types of fuel in Ukraine decreased, except for propane and liquefied butane. However, in 2021, the demand for all fuel types increased significantly. In 2021, compared to 2020, the cost of all types of fuel in Ukraine also increased. This trend of increasing the cost of fuel will continue in 2022. At the same time, fuel prices differ depending on the market operators. It has been established that the Ukrainian market of light oil products is quite competitive. However, today almost 40% of all high-octane gasoline and diesel fuel in our country are sold only by three large chains operating under such brands as WOG and OKKO, as well as UKRNAFTA. A feature of the market of light oil products of Ukraine is significant dependence on imported supplies, the share of which in 2021 reached 80 %. Logistical links in the export of oil products from European markets were not developed. In the market of light oil products in Ukraine, their sellers use primarily non-price competition tools. The loyalty of the gas station network customers is implemented through various marketing activities (advertising, social and environmental projects). In martial law conditions, the issue of providing fuel to the economy of Ukraine and the population became more acute. During the first six months of the war in 2022, Ukraine increased its fuel imports 12 times, satisfying market demand. During this period, our country received 95 % of imported gasoline, as well as 72 % of diesel fuel, from EU countries. The consumer survey results showed that gasoline A-95 and diesel fuel, which meet Euro standards, predominate among the popular types of fuel in Ukraine. Customers' choice of gas stations is most influenced by their convenient location and the fuel level in the tank. The most popular gas station chains for the respondents are OKKO and WOG gas station chains. Among the additional services at gas stations, the most popular are purchasing food and drinks, free Wi-Fi, food and non-food products, parking, and car washing. The most promising additional services at gas stations include a mechanic's consultation, medical corner, use of terminals and ATMs, car wash, free Wi-Fi, parking, and Internet ordering points. Prospects for developing the market of light oil products in Ukraine depend primarily on the end of the war in Ukraine and the reconstruction of its economy. The Polish company Orlen can be considered the most likely partner for agreeing to process Ukrainian oil to produce the fuel necessary for Ukraine further.
LESSONS FROM THE MARSHALL PLAN: GAINING PUBLIC SUPPORT, PREREQUISITES FOR SUCCESS, AND KEY EMPHASES FOR UKRAINE
Authors:   Dolishniy Institute of Regional Research of NAS of Ukraine, Nestor O.Yu.
Published: August 2023

The article reveals the peculiarities of the Marshall Plan or the European Recovery Program after World War II. In particular, three phases of the Marshall Plan are described (the first one began two years after the end of World War II and was characterized by the threatening situation in Europe; the second phase began when the process of European economic recovery approached the pre-war 1938 level and was characterized by concerns about the sustainability of these achievements, their maintenance, and improvement; the third phase began with the war on the Korean Peninsula and was marked by a gradual change in the Marshall Plan's course towards international security and defense). The propaganda aspect of the Marshall Plan and the process of its development are outlined. The article analyzes the prerequisites for the success of the Marshall Plan, which include the following: personnel and selection policy; organizational structure of the ECA; institutional prerequisites; psychological aspect; attention to detail: approach to foreign policy making, decisionmaking process, problem-solving method; management style. The article emphasizes that the idea that economics, politics, and psychology are inseparable in the process of creating support and rebuilding other countries was an important feature and basis for the development and implementation of the Marshall Plan. The author identifies the unique features of the Ukrainian context to be taken into account in the process of developing a “Marshall Plan for Ukraine” for its recovery after the Russian-Ukrainian war, in particular, the geopolitical aspect and the importance of geopolitical support from Ukraine's partners, as well as the need to restructure the Ukrainian economy in a modern way. The article argues that the lessons of the Marshall Plan for Western Europe can and should be used in the development of the “Marshall Plan for Ukraine”. The situation with the creation of an analog of the Marshall Plan for Ukraine will have its own unique specifics, as the recipient of assistance will be one country, and the circle of donors will be wider. Mutually beneficial partnership and respect between the recipient and donors, as well as the optimal organizational and management structure of the organization that will be involved in the reconstruction of Ukraine, are important.
ОСОБЛИВОСТІ ФОРМУВАННЯ СТРУКТУРНОЇ НЕОДНОРІДНОСТІ У ВУГЛЕЦЕВІЙ СТАЛІ ЗАЛЕЖНО ВІД СПОСОБУ ВИГОТОВЛЕННЯ
Authors: Бабаченко О. , Балаханова Т. , Сафронова О. , Подольський Р.
Published: August 2023

Вступ. Гомогенна, однорідна мікроструктура габаритних металевих виробів є найбільш переважною при забезпеченні необхідного комплексу властивостей.Проблематика. Режими деформаційної та термічної обробки, які застосовують сьогодні, потребують коригування залежно від особливостей виплавки сталі для забезпечення високого комплексу властивостей металопродукції.Мета. Проаналізувати вплив розміру вихідної безперервнолитої заготовки (БЛЗ), її геометрії, ступеню пророблення готової залізничної осі й дослідити вплив ступеня чистоти сталі на особливості структуроутворення вже готового продукту — залізничних осей.Матеріали й методи. Всі дослідні зразки відібрані з 1/2 товщини шийки чорнових залізничних осей. Розмір осей був однаковий і становив ∅ 218 мм. Всі осі пройшли дві нормалізації за температур 820 та 840 °С відповідно. Фото мікроструктур зроблено на Axiovert 200 MAT.Результати. В результаті проведених експериментів показано, що основні відмінності структуроутворення кінцевої структури, що виявлялися у готових залізничних осей, виготовлених з заготовок різного способу виготовлення, спостерігаються і при проведенні експериментальної термічної обробки недеформованої заготовки. Деформація призводить лише до пом’якшувальної дії процесів впливу литої вихідної структури, лікваційної неоднорідності, недосконалості будови тощо.Висновки. Визначено, що при виборі оптимального хімічного складу сталі для виготовлення відповідальних деталей залізничного призначення, необхідно брати до уваги спосіб виробництва сталі, вихідні матеріали та технологічні особливості металургійного підприємства, оскільки сталь навіть близького хімічного складу може мати різну природу структуроутворення. З’ясовано, що формування феритного облямування біля сульфідних включень має природу формування, схожу з утворенням газових бульбашок, і демонструє характерну структуру. Наявність сульфідних включень обумовлена насамперед одночасним перебуванням їх в лікваційній зоні поруч з іншими лікватами й газами в сталі.
Fluctuating Asymmetry and Length-Weight Relationship of the Three Populations of Sardinella lemuru (Clupeiformes, Dorosomatidae) from Surigao del Norte, Philippines
Authors: Cinco J. G. , Farma J. , Silvosa J. D. , Weling C. B. , Cuadrado J. T.
Published: August 2023

Despite its economic importance and current conservation status, studies on Sardinella lemuru (Bleeker, 1853) are very scarce in the province of Surigao del Norte, Philippines, so this study was conducted to assess the body shape and health status of fish populations in the area using fluctuating asymmetry (FA) and length-weight ratio (LWR) analyses. 258 individuals were collected from the coastal waters of Malimono (n = 6), San Francisco (n = 101) and Surigao (100) from August to October 2021 using fishnets and gillnets. Among the three populations, fish samples from Malimono have the highest cumulative variation of 63.07 % followed by San Francisco and Surigao City (60.85 % and 55.51 %). The high percentage of FA among the three populations (57.66 % in Malimono; 54.43 % in San Francisco; and 49.78 % in Surigao City) also suggests that individuals had deformities particularly, especially in the fins and head region of the fish. The LWR of the fish samples (b = 2.6398 in Malimono; b = 2.7541 in San Francisco; and b = 2.8377 in Surigao City) indicates a negative allometric growth pattern, suggesting that the fish samples do not grow symmetrically or become thinner with increasing length. The results of FA and LWR analyses suggest morphological abnormalities in the fish samples that may be attributed to the different environmental stressors in the area. Studies on sex differences, water quality and fish ecology are suggested to better understand the current status of fish in the area.
Late Miocene Turtles of Grytsiv (western Ukraine) with Rodent Gnaw Marks on the Carapace Surface
Authors: Yanenko V. , Kovalchuk O.
Published: August 2023

The paper describes a series of turtle remains from the Early Late Miocene of Grytsiv (Khmelnytskyi Oblast, Ukraine). This fossil assemblage was quite diverse and included representatives of four families (Emydidae, Geoemydidae, Testudinidae, and Trionychidae), most of which are described only to the family level due to incompleteness. The discovery of shell fragments, identified here as Testudo chernovi, is the earliest record of this species on the territory of Ukraine. Scratches on the nuchal of T. chernovi are interpreted as traces of gnawing or rasping and are described as a new ichnospecies, Machichnus inrosus isp. n. These traces are identified as gnawing marks of the rodent Anomalomys grytsivensis, as evidenced by the width of the lower incisors and the presence of two characteristic longitudinal ridges on their labial surface.
Helminth Fauna in Carnivoran Mammals from Uzbekistan
Authors: Safarov A. , Khan A. , Azimov D. , Akramova F. , Saparov K. , Ben Said M.
Published: August 2023

Helminths, or parasitic worms, are a group of organisms that can infect various animal species, including humans. In Uzbekistan, previous studies on the helminth fauna of mammals have mainly focused on domestic animals and some wildlife species, with little attention given to carnivoran mammals. This survey aims to conduct a comprehensive study for the first time in Uzbekistan on the helminth fauna of Carnivora. In this study, helminths were collected from 1002 carnivorans (Canidae, n = 710; Mustelidae, n = 167; and Felidae, n = 125) from five locations in Uzbekistan (Northeastern, Eastern, Central, Southern and Northwestern). A total of 71 species of helminths were identified in domestic and wild carnivores by necropsy and faecal examination, of which 36, 23, 9, and 3 species belonged to the higher taxon Nematoda, Cestoda, Trematoda and Acanthocephala respectively. The highest number of helminth species was recorded in studied Canidae (51 species), followed by Felidae (40 species) and Mustelidae (35 species). The overall infection rate of carnivorans was 79.8 %. Infection intensity ranged from a single to dozens of specimens. The statistical analysis indicated that the diversity of helminth species is significant among members of Canidae, with foxes having 42 species and dogs having 41 species (P < 0.05). Our study proves that the parasitic worm species that inhabit predatory mammals in Uzbekistan are a diverse and complex group that can cause helminthiases, which may be dangerous to livestock and humans.
Enzymatic hydrolysates from camel colostrum and milk proteins display inhibitory activity toward a key enzyme related to obesity
Authors: Olfa O. , Zeineb J. , Halima E.H.
Published: August 2023

This study aimed to investigate the anti-obesity potential of camel colostrum and milk proteins as well as their enzymatic hydrolysates. Camel colostrum and milk proteins were treated using six proteolytic enzymes (pepsin, trypsin, α-chymotrypsin, pancreatin, papain, and pronase). The degree of hydrolysis was measured to verify the degradation of proteins. The in vitro anti-obesity activity was evaluated using the pancreatic lipase inhibitory assay. Camel colostrum and milk protein hydrolysates exhibited different degrees of hydrolysis ranging from 17.69 to 43.97%. The protein content varied between 56.08–61.95% and 37.39–41.72% for camel colostrum and milk protein hydrolysates, respectively. The hydrolysates displayed significantly higher anti-obesity activity than the undigested proteins at all tested concentrations (P < 0.05). Colostrum protein hydrolysate generated with pancreatin had the highest anti-obesity potential (59.92%). These results suggest that colostrum and milk protein hydrolysates could be used to formulate functional foods and nutraceuticals.
Course features and functional condition of pancreas in adolescents with gastroesophageal reflux disease
Authors:   Ivano-Frankivsk National Medical University, Ukraine, Lembryk І.S. , Zhyliak О.V. ,   Ivano-Frankivsk National Medical University, Ukraine, Stefanyshyn А.B. ,   Ivano-Frankivsk National Medical University, Ukraine, Tsytsiura О.О. ,   Ivano-Frankivsk National Medical University, Ukraine, Slimkevych І.V. ,   Ivano-Frankivsk National Medical University, Ukraine
Published: August 2023

Chronic acid-dependent diseases and, in particular, gastroesophageal reflux disease (GERD), are urgent problems in pediatric gastroenterology. However, the clinical features and functional state of the pancreas in adolescents with reflux disease remain not fully understood. Purpose - to investigate the main parameters of quality of life, clinical features, and functional state of the pancreas in adolescents with GERD. Materials and methods. We examined 100 inpatients aged 13-17 years who were hospitalised in the period between 2016 and 2022. The diagnosis was verified according to modern protocols of diagnosis and treatment, and the results were statistically processed using the Statistica for Microsoft 7.0 software package. Results. Of the children we examined, 80.0% had endoscopically positive (non-erosive form) GERD, with 50.0% having concomitant functional pancreatic disorders. The most significant changes in blood amylase were noted in patients with comorbidity (120.5±0.1 g/(hr×L) and 33±0.3 g/(hr×L), p<0.05) and in patients with the erosive form of GERD (98.1±0.2 g/(hr×L) and 25±0.1 g/(hr×L), p<0.05). Serum lipase levels were also more pronounced in patients with comorbid GERD (70±0.1 U/L and 35±0.2 U/L, χ2=32, p<0.0001). In these teenagers, there was a violation of the quality of life according to the main parameters: heartburn, regurgitation, sleep disorders (the sum of points on three scales was 14.95±0.36 (95% confidence interval: 14.85-15.05) in combination with the appearance of pathology. 11.25±0.65 (95% confidence interval: 11.02-11.48) points - in patients with an isolated course of the disease, erosive form (р˂0.001). Conclusions. The clinical features of GERD in combination with functional pancreatic disorders include severe abdominal pain localized in the pyloric duodenal zone and left hypochondrium. In adolescents with comorbid GERD, the levels of organ-specific enzymes were more often increased compared to the control group. Quality of life was significantly changed in them too. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
Clinical and genetic characteristics of young children with epileptic encephalopathies and their role in the development of autism spectrum disorders
Authors:   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Kyrylova L.G. , Miroshnikov O.O. ,   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Badyuk V.M. ,   «Ultragenom», LLC, Kyiv, Ukraine, Dolenko O.O. ,   «Ultragenom», LLC, Kyiv, Ukraine
Published: August 2023

Purpose - to analyze the clinical and genetic characteristics of young children with developmental and epileptic encephalopathies and to determine their role in the formation of autism spectrum disorders (ASD). Materials and methods. The study included 58 children aged 0-3 years with the onset of epileptic seizures in the first year of life, clinical manifestations of developmental and epileptic encephalopathies with genetic etiology. The examination included assessment of neurological status, collection of anamnesis, assessment of semiology and determination of seizure type, assessment of development and screening for ASD at the age of 18 and 24 months, night sleep electroencephalography (video EEG), brain magnetic resonance imaging (MRI), screening for pathogenic variants by whole-exome sequencing or examination of relevant gene panels. Pathogenic variants of 33 different genes were found in the examined children. Pathogenic variants of genes responsible for the function of ion channels (41.3%), intracellular signaling systems (17.2%), organelles and intracellular membranes (12.1%) were most frequently found. 44.8% of children had symptoms of ASD at the age of 18 months, and 68.9% of children at the age of 24 months. The predominant types of epileptic seizures were myoclonic (37.9%) and focal clonic (34.4%). According to video EEG monitoring, interictal focal (39.6%) and multifocal (22.4%) epileptiform changes dominated in the examined children. According to MRI, structural changes of the brain were found in 86.2% of children. Conclusions. It is shown that children with a history of myoclonic seizures (RR=1.264) and infantile spasms (RR=1.44) have a high risk of developing ASD at 24 months. It has been established that there is a positive relationship between the presence in the child of mutations in the genes responsible for the functioning of ion channels (RR=1.32), as well as for the functioning of synapses, neurotransmitters and receptors (RR=1.5) and the development of ASD in 24 months. The research was carried out in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Bioethics and Deontology Commission. Informed consent of the children’s parents was obtained for the research. No conflict of interests was declared by the authors.
Exhaled phospholipids as a prognostic factor of pulmonary complications in children with acute lymphoblastic leukemia
Authors:   Kharkiv National Medical University, Ukraine, Makieieva N.I. , Koval V.A. ,   Kharkiv National Medical University, Ukraine, Gorbach T.V. ,   Kharkiv National Medical University, Ukraine
Published: August 2023

Introduction. Pulmonary complications are common in children with acute lymphoblastic leukemia (ALL). The assessment of phospholipids (PL) in the exhaled breath condensate can provide more information about pathological processes in the lungs in children with ALL. Purpose - to assess the level of PL in the exhaled breath condensate (EBC) in children with ALL and its prognostic value. Materials and methods. 40 children with ALL aged 6-17 years were examined. 1st group included newly diagnosed children with ALL (n=18). 2nd group involved ALL survivors, who had completed the total course of chemotherapy (n=22). The control (С) group consisted of 15 healthy children. The levels of PL in the EBC were investigated by spectrophotometric thin-layer chromatography using an SPh 46 spectrophotometer. Results. The frequency of pulmonary complication was 82.5% during chemotherapy protocols and 18.4% in ALL survivals. The statistically significant increase in the level of phospholipids in 1st (150.75 (137.62; 158.45) mmol/l) and 2nd (130.12 (120.59; 138.34) mmol/l) ALL groups compared with the group C (54.80 (48.30; 60.80) mmol/l) has been detected (p1-C=0.0000; p2-C=0.0000). Children of the 1st group had significantly higher levels of PL in the EBC than children of the 2nd group (p1-2=0.002911). PL level in EBC collected during induction phase of chemotherapy >132.15 mmol/l can be prognostic for the development of acute pulmonary complications (Sensitivity 93.75%; Specificity 100%). PL level in EBC collected after a complete course of chemotherapy >133.28 mmol/l can be predictive for persistent pulmonary complications (Sensitivity 100.00%; Specificity 83.33%). Conclusions. PL level in EBC can be prognostic for the development of pulmonary complications, both during chemotherapy and in long-term remission after completed chemotherapy course. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
Prevalence of antibodies to SARS-COV-2 in children and adolescents: a single-center study
Authors:   Kharkiv State Academy of Physical Culture, Ukraine, Shlyakhova N.V. , Rak L.I. ,   SІ «Institute for Children and Adolescents Health Care of the NAMS of Ukraine», Kharkiv, Shevchenko N.S. ,   SІ «Institute for Children and Adolescents Health Care of the NAMS of Ukraine», Kharkiv,   V.N. Karazin Kharkiv National University, Ukraine, Holovko T.O. ,   SІ «Institute for Children and Adolescents Health Care of the NAMS of Ukraine», Kharkiv,   V.N. Karazin Kharkiv National University, Ukraine
Published: August 2023

Despite the fact that children with COVID-19 are usually asymptomatic or mild, infection with SARS-CoV-2 is more likely to lead to the development of an antibody response. Understanding humoral immunity to SARS-CoV-2, including in children, is critical for future public health and vaccination strategies. Children with chronic diseases deserve special attention. Purpose - to study the prevalence of positive antibodies to SARS-CoV-2 in children and adolescents who were in paediatric hospital without signs of viral disease to develop future healthcare strategies. Materials and methods. In 32 children aged 6-17 years (14 (43.8%) boys and 16 (56.2%) girls) quantitative determination of IgG antibodies to SARS-CoV-2 in blood serum was carried out by enzyme immunoassay using commercial SARS-CoV-2 S1\RBD IgG Ab ELISA (TECAN, IBL International GmbH, Germany). Results. The majority (n=27, 84.4%) of children had a positive level of class G antibodies to SARS-CoV-2. 7 (25.9%) children had a positive PCR test in their anamnesis, 6 (18.8%) persons provided information about the infection transmitted by family members. Clinical manifestations characteristic of SARS-CoV-19 were present in 2 (7.4%) children. Parents of 18 (66.7%) children claimed that their children had no symptoms of COVID-19, while family members of 6 (33.3%) children had cases of the disease. All children (n=6, 18.8%) who were vaccinated with two doses of Comirnaty® vaccine had positive IgG antibodies to SARS-CoV-2. Antibodies to SARS-CoV-2 were absent in 5 (15.4%) people, all of them were patients with type 1 diabetes. Conclusions. The study of the prevalence of antibodies to SARS-CoV-2 provides important information about circulating antibodies against SARS-CoV-2 in children and adolescents, in particular those with chronic diseases. The obtained results showed the predominant seropositivity of children, which is formed regardless of the clinical manifestations of the disease. A high level of antibodies under the conditions of revaccination confirms the benefit of revaccination of children to strengthen memory formation. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
Post-traumatic stress disorder in children: early recognition and coordination of medical care in the conditions of war
Authors:   Dnipro State Medical University, Ukraine, Mokia-Serbina S.O. , Zabolotnia N.I. ,   Dnipro State Medical University, Ukraine, Mavropulo M.I. ,   Dnipro State Medical University, Ukraine
Published: August 2023

At the current stage, when military operations continue and there is possible development of various manifestations of psychotraumatic stress disorders in children, the acuteness and urgency of solving the problem determines the need for early recognition of the symptoms of post-traumatic stress disorder, due to its frequency and high risk and indicators of negative consequences. Purpose - to improve the quality of life of children in wartime conditions by early recognition of symptoms of the risk of developing post-traumatic stress disorder and increasing the awareness of primary care physicians about this condition and coordination of medical and psychological care. Materials and methods. Practical guidelines on the early recognition of symptoms of the risk of developing post-traumatic stress disorder in children are presented in the national Adapted clinical guideline based on evidence (2016), Unified clinical protocol (primary, secondary (specialized) and tertiary highly specialized medical care) (2019), as well as the guidelines of the National Institute for Health and Clinical Improvement of Great Britain (NICE, 2018) and information from PubMed databases, UpTo Date. For determining these recommendations the new version of the International Classification of Diseases (ICD-11) was taken into account. Results. An analysis of clinical guidelines and scientific literature related to the study of post-traumatic stress disorder in children, in particular, its early recognition by primary care physicians, was carried out. The question of the peculiarities of the clinical course of psychotraumatic disorders depending on the time of their appearance after a traumatic event and the age of children is highlighted. In the context of the time that has passed since the traumatic event and the age of the children, a screening program for the early recognition of symptoms of the risk of developing post-traumatic stress disorder, which require immediate response by primary care workers, is presented. Special attention was paid to children from war zones, geographically remote regions, displaced persons, refugees. Conclusions. Early conducting of a short screening assessment of the risk of developing post-traumatic stress disorder in children, a timely decision on the provision of medical and psychological assistance, will contribute to the improvement of their quality of life in wartime conditions. No conflict or interests was declared by the authors.
Clinical case of alopecia totalis in pediatric practice
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Stroi O.А. , Кyian Т.А. ,   Bogomolets National Medical University, Kyiv, Ukraine, Balatska N.I. ,   Bogomolets National Medical University, Kyiv, Ukraine,, Levadna L.O. ,   Bogomolets National Medical University, Kyiv, Ukraine, Kozynkevych G.E. ,   Bogomolets National Medical University, Kyiv, Ukraine
Published: August 2023

Alopecia (baldness) is a pathological hair loss. A chronic relapsing course leads to a violation of the emotional sphere of the child, worsens the quality of life. Alopecia is considered autoimmune, since it is characterized by hair loss due to lymphocytic infiltration around the hair follicles. It can be secondary as a result of infectious and inflammatory processes. Purpose - is to conduct own clinical observation of a child with total alopecia to increase the awareness of doctors about this pathology in children. Clinical case. The article presents a clinical case of total alopecia in an 11-year-old child. It is known from the anamnesis that in 9 months the child began to lose hair on his head, at 2 years old - eyebrows and eyelashes, at 3 years old he was diagnosed with total alopecia. The patient had a complex clinical and laboratory examination with the involvement of a multidisciplinary team, since alopecia can occur under the mask of autoimmune diseases and immunodeficiencies. Total alopecia, atopic dermatitis, changes in immunological status in the anamnesis, cases of early mortality among family members, as well as a history of alopecia areata in the father gave us reason to suspect a genetic disease in the patient, including autoimmune polyendocrinopathy candidiasis-ectodermal dystophia (APECED syndrome) with mutation in the AIRE gene. Conclusions. For verification the diagnosis and choose a treatment strategy, the patient needs an additional examination: sequencing of the relevant locus of the AIRE gene to detect mutations characteristic of APECED syndrome, as well as a serological test to detect the titer of antibodies to Candida and a puncture biopsy of the scalp. Considering the above, the prognosis for recovery is unfavorable. The research was carried out in accordance with the principles of the Declaration of Helsinki. Informed consent of parents was obtained for the study. No conflict of interests was declared by the authors.
MULTI-DIMENSIONAL SUSTAINABILITY ASSESSMENT IN MICRO-BUSINESS OF SIAMESE FIGHTING FISH CULTIVATION DURING THE COVID-19 PANDEMIC
Authors: Sukwika Tatan , Sukamdani Nugroho B
Published: August 2023

The economic value of Siamese Fighting fish and betta fish (Betta splendens) cultivation at the micro-business level has good potential to be developed during the COVID-19 pandemic. Considering the potential of the betta ornamental fish business, not a few parties use this as an alternative solution to the community's income crisis. During the COVID-19 pandemic, many parties engaged as ornamental fish cultivators to become a commodity of economic value, which in the past was usually only fish for complaints and not specifically cultivated to become aesthetic fish. The research objective focuses on assessing multi-dimensional sustainability in micro-business Betta splendens aquaculture during the pandemic. The data collected in this study include primary data and secondary data. Primary data was collected based on a questionnaire through interviews with micro-business actors of betta fish spread across six villages community associations, while secondary data was collected based on reports, journals, and the results of relevant studies. Data analysis used multi-dimensional scaling (MDS), leverage test, and Monte Carlo test. The analysis results show that two dimensions are categorized as less sustainable, namely business feasibility and business strategy, and three other dimensions, namely market networks, infrastructure, and maintenance and handling categorized as moderately sustainable. Ten sensitive attributes are considered unstable. The conclusion of the five dimensions assessed shows a less sustainable category. Leveraging factors in each dimension can be a key to developing a sustainable strategy for micro-business siamese fighting  fish farming in the future.
How to Disappear Completely
Authors: Johnstad Petter Grahl
Published: August 2023

This article presents an interview study of self-dissolution experiences induced by entheogenic or psychedelic drugs, with the aim of broadening our understanding of the nature and characteristics of such experiences. Respondents (N=37) were recruited at various online fora for individual interviews via private messaging. They reported a wide variety of experiences that involved some form of self-dissolution, ranging from the disruption of self-related illusions to experiences of bodilessness and total immersion in another reality. Several interviewees also reported a temporary transformation of their identity, where they went from seeing themselves as a separate individual to an experience of oneness with all of humanity or with a transcendent force. There were also reports of telepathic contact between friends or partners who used entheogens together, and in their most intense form, these experiences involved what was described as a mind blending where one’s usual sense of selfhood dissolved into the telepathic unity.
The Gathering: A Story of the First Buddhist Women
Authors: Sasson Vanessa R.
Published: August 2023

Sasson’s new book is a retelling of the story of the women’s request for ordination. Inspired by the Therigatha and building on years of research and experience in the field, Sasson follows Vimala, Patachara, Bhadda Kundalakesa, and many others as they walk through the forest to request full access to the tradition. The Buddha’s response to this request is famously complicated; he eventually accepts women into the Order, but specific and controversial conditions are attached. Sasson invites us to think about who these first Buddhist women might have been, what they might have hoped to achieve, and what these conditions might have meant to them thereafter. By shaping her research into a story, Sasson invites readers to imagine a world that continues to inspire and complicate Buddhist narrative to this day.
SAFE: EFFICIENT DDOS ATTACK DEFENSE WITH ELASTIC TRAFFIC FLOW INSPECTION IN SDN-BASED DATA CENTERS
Authors: Nguyen Tri Gia , Hoang Nguyen Hai , Phan Trung
Published: August 2023

In this paper, we propose an efficient distributed denial-of-Service (DDoS) Attack deFEnse solution, namely SAFE, which utilizes an elastic traffic flow inspection mechanism, for Software-Defined Networking (SDN) based data centers. In particular, we first examine a leaf-spine SDN-based data center network, which is highly vulnerable to volumetric DDoS attacks. Next, we develop a rank-based anomaly detection algorithm to recognize anomalies in the amount of incoming traffic. Then, for the traffic flow inspection, we introduce a component called DFI (Deep Flow Inspection) running an Open vSwitch (OvS) that can be dynamically initiated (as a virtual machine) on-demand to collect traffic flow statistics. By utilizing deep reinforcement learning-based traffic monitoring from our previous study, the DFIs can be protected from the flow-table overflow problem while providing more detailed traffic flow information. Afterward, a machine learning-based attack detector analyzes the gathered flow rule statistics to identify the attack, and appropriate policies are implemented if an attack is recognized. The experiment results show that the SAFE can effectively defend against volumetric DDoS attacks while assuring a reliable Quality-of-Service level for benign traffic flows in SDN-based data center networks. Specifically, for TCP SYN and UDP floods, the SAFE attack detection performance is improved by approximately 40% and 30%, respectively, compared to the existing SATA solution. Furthermore, the attack mitigation performance, the ratio of dropped malicious packets obtained by the SAFE is superior by approximately 48% (for TCP SYN flood) and 52% (for UDP flood) to the SATA.
OPTIMAL TRACKING CONTROL FOR ROBOT MANIPULATORS WITH ASYMMETRIC SATURATION TORQUES BASED ON REINFORCEMENT LEARNING
Authors: Dien Nguyen Duc , Luy Nguyen Tan , Lai Lai Khac
Published: August 2023

This paper introduces an optimal tracking controller for robot manipulators with asymmetrically saturated torques and partially - unknown dynamics based on a reinforcement learning method using a neural network. Firstly, the feedforward control inputs are designed based on the backstepping technique to convert the tracking control problem into the optimal tracking control problem. Secondly, a cost function of the system with asymmetrically saturated input is defined, and the constrained Hamilton-Jacobi-Bellman equation is built, which is solved by the online reinforcement learning algorithm using only a single neural network. Then, the asymmetric saturation optimal control rule is determined. Additionally, the concurrent learning technique is used to relax the demand for the persistence of excitation conditions. The built algorithm ensures that the closed-loop system is asymptotically stable, the approximation error is uniformly ultimately bounded (UUB), and the cost function converges to the near-optimal value. Finally, the effectiveness of the proposed algorithm is shown through comparative simulations.
OPTIMAL TRACKING CONTROL FOR ROBOT MANIPULATORS WITH INPUT CONSTRAINT BASED REINFORCEMENT LEARNING
Authors: Dien Nguyen Duc , Luy Nguyen Tan , Lai Lai Khac , Hai Tran Thanh
Published: August 2023

This paper introduces an optimal tracking controller for robot manipulators with saturation torques. The robot model is presented as a strict-feedback nonlinear system. Firstly, the position tracking control problem is transformed into the optimal tracking control problem. Subsequently, the saturated optimal control law is designed. The optimal control law is determined through the solution of the Hamilton-Jacobi-Bellman (HJB) equation. We use a reinforcement learning algorithm with only one neural network (NN) to approximate the solution of the equation HJB. The technique of experience replay is used to relax a persistent citation condition. By Lyapunov analysis, the tracking and the approximation errors are uniformly ultimately bounded (UUB). Finally, the simulation on a robot manipulator with saturation torques is performed to verify the efficiency of the proposed controller.
AN IN-DEPTH EVALUATION OF FREQUENCY-AWARE SCHEDULER FOR IMPROVING USER EXPERIENCE ON MOBILE DEVICES
Authors: Tran Giang Son , Carlier Axel , Hagimont Daniel
Published: August 2023

Mobile devices are more and more invading our daily life. Users of such devices expect to have a good experience, which is mainly linked with performance. However, higher performance also means a reduction in battery life, negatively contributing to the overall user experience. A common way to balance this performance-battery trade-off is to reduce CPU frequency when underload with Dynamic Voltage and Frequency Scaling. In our previous work, we introduced a Frequency-Aware Completely Fair Scheduler (called FA-CFS), which helps in reducing battery consumption and increasing the smoothness of mobile interface browsing. However, the current evaluation of FA-CFS model is only at quantitative results of power consumption rather than user experience on using their mobile device. In this paper, we perform an in-depth evaluation of the FA-CFS model, both quantitative results for system performance evaluation and qualitative results for user experience on mobile device usage. The experiments show that FA-CFS can reduce the rate of interface frame time peaks by up to 40% in terms of quantitative results and obtains a quantifiable impact on the quality of user experience with a quicker, more responsive interface.