bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Negative Personality Memories on the Features of Self-Perception
Authors: Ivanova Olena , Bondarenko Anastasiya
Published: April 2023

The question of the memory impact on personality is topical and requires experimental research. The article presents theoretical analysis of autobiographical memory aspects that can combine the areas of personality functioning and mnemonic processes. In the context of the development of G.K. Sereda's ideas about the relationship and interaction of memory and personality, an empirical study was conducted to elicit the impact of negative memories on self-perception characteristics of personality in middle-aged and older people. R. Cattell's Sixteen Personality Factor Questionnaire was chosen as a method of studying the peculiarities of self-perception. Between two stages of the questionnaire application we used the autobiographical interview, designed to actualize negative memories, that took the position of experimental intervention and became a source of memories as a material for qualitative analysis. The study involved 32 participants from different professions with a middle age fluctuating near 57. It has been found that among middle-aged and older people the actualization of negative memories leads to certain changes in personality self-perception immediately after the process of recollection. Above all, these changes refer to self-control, courage, self-esteem, dominance, warmth, emotional stability, abstractedness, apprehension, self-reliance, openness to change, vigilance, liveliness, sensitivity, privateness and rule-consciousness. So undoubtedly, negative memories have some influence on changes in one's vision of one's own personality, but variously, in different ways. As it has been demonstrated, these changes are related to the organization of the narrative, the accompanying and following reactions, the thematic focus of the story etc. The obtained results confirmed G.K. Sereda`s assumption about the impact of memory on the personality, at least within a short period of time.
The Qualities of Romantic Relationships and Emotional Creativity of Hetero- and Homosexual Couples Representatives - Do They Love Differently in the Female Sexual Minority?
Authors: Lutsenko Olena , Artiukhova Vladislava , Zimovin Oleksii , Verbovata Valeriia
Published: April 2023

Studies of the characteristics of hetero- and homosexual couples relationships are fragmentary. Modern Ukrainian society remains insufficiently aware of this issue, which leads to the stigmatization of a person because of his sexual orientation. The purpose of our study was to determine the relationship between emotional creativity and the quality of love relationships in hetero- and homosexual couples. The sample consisted of 20 heterosexual and 20 homosexual female couples (60 women and 20 men) aged 18-40. R. Sternberg's "Triangular Scale of Love", J. Avrill's questionnaire "Emotional Creativity", S. Khedrik's and K. Khedrik's "Psychological Types of Love" questionnaire, T. Rumyantseva's "Circle of Relationships" projective method (2006) were used for diagnosis. It was found out that regardless of sexual orientation, partners in romantic relationships are characterized by the same pronounced emotional creativity and have the similar quality of love relationships. It was determined that love-friendship prevails in all pairs, they also have partially symbiotic relationships, which are more pronounced in some heterosexual couples. Homosexual couples are characterized by more symmetrical relationships, although, as in heterosexual couples, there is a reaction of alienation in response to an attempt to build a symbiotic relationship by another partner. The revealed connections of emotions novelty with love obsession in lesbians and love pragmatism in heterosexual couples indicate the specificity of this emotional creativity component manifestation depending on the sexual orientation of the couples.
The Emotional Sphere of Women Staying in the Anti-Terrorist Operation Zone for a Long Time
Authors: Kreydun Nadiya , Kharchenko Andrii , Nalyvaiko Oleksii , Sevostianov Pavlo , Zotova Liliya , Nevoenna Olena , Iavorovska Liubov , Lukianova Viktoriia
Published: April 2023

In Ukraine, an anti-terrorist operation, carried out on a significant territory of the country (about 20 percent) has been going on for eight years. All this time, hundreds of thousands of Ukrainians stay in stressful conditions. Changes occur in cognitive, behavioral, value-motivational, emotional and other spheres of these people personality. One of the risk groups is middle-aged people, because the key tasks for this stage of a person's life become difficult to implement. In women, the emotional component of this process is more intense than in men, which becomes an additional stress factor in this situation. There are studies on the emotional component in interpersonal relationships in these women, their tendency to affect, the consequences of receiving traumatic experience, impulsiveness, etc. However, the number of studies on the peculiarities of basic emotions manifestation, level indicators of anxiety, aggressiveness and other components of the emotional sphere remains insignificant, which would make it possible to develop appropriate psychocorrective programs. The purpose of the study was to identify the features of emotional sphere in middle-aged women who have been in the area of anti-terrorist operation (ATO) for a long time. Research methods – a technique for measuring the level of anxiety (J. Taylor), a scale of differential emotions (K. Izard), a technique for detecting the level of aggressiveness (Bassa-Darky). Mathematical and statistical processing - φ-criterion Fisher's angular transformation. The subjects were 40 middle-aged women employed with higher education. They are divided into two groups of 20: according to the criterion, they were in the area of anti-terrorist operation (ATO) for a long time and had never been in the specified territory. Conclusions: for the emotional sphere of middle-aged women who have been for a long time (at least 5 years) in the area of anti-terrorist operation (ATO), the phenomena of "level decrease of emotions of the positive spectrum" and "level increase of aggressiveness" and a high general level of anxiety are characteristic. In the anxiety-depressive spectrum of the emotional sphere, guilt becomes the dominant emotion. There is a tendency to increase more open forms of aggressiveness, but the manifestation of anger, on the contrary, is becoming more moderate.
Diagnostics of Professional Identity Statuses in Ukraine: Comparison of the Results of Two Questionnaires
Authors: Malofeikina Kateryna
Published: April 2023

The article deals with the problem of using questionnaires to study professional identity in Ukraine. Now there is a significant lack of methods for studying professional identity, the obsolescence of their methodology, as well as the lack of Ukrainian-language tools. The purpose of this study was to compare the results of two methods of studying professional identity statuses in the Ukrainian scientific space – the method of studying professional identity of L.B. Schneider and the questionnaire of professional identity statuses of students by A.A. Ozerina. These two methods are among the most commonly used for diagnosing the professional identity of adult subjects, regardless of their professional affiliation. During the investigation, a cluster analysis was performed to take into account all possible variants of the formation of professional identity statuses according to A.O. Ozerina, after which the results of both methods were compared by calculating percentages, as well as applying the Pearson's chi-squared test. The results showed a weak correspondence between the statuses of professional identity according to L.B. Schneider and A.O. Ozerina: of all the options for calculating statuses and ways to avoid the problem of pseudo-positive identity, only the achieved identity coincided between the two methods in 4.3% -17% of cases from the total number of subjects studied. Especially problematic was the determination of premature identity, the percentage of coincidence between methods for which in none of the calculation options exceeded 2.2% of cases from the total number of subjects studied. In addition, the absence of a statistically significant relationship between the questionnaires considered was determined using Pearson's chi-squared test. Suggestions are made about the inexpediency of using or adapting these questionnaires in Ukrainian.
Psychological Factors Of Intragroup Process Efficiency Within Modern Organizations
Authors: Varava Liudmila , Dekaliuk Yelyzaveta
Published: April 2023

The article is devoted to consideration of the problematic issue of improving productivity and increasing the efficiency of management, which is faced by the managers of Ukrainian enterprises and organizations providing social services in the competitive market of goods supply in conditions of full-scale war. Since the organization’s high performance indicators may provide an advantage over competitors and boost financial success, each organization, in turn, strives to become a leader and even a monopolist in a competitive market by its own means. Depending on the productivity of such actions, the organization may gain a significant competitive advantage, which is an integral component of business economic opportunities that can be employed to achieve strategic goals and objectives. Given the current economic behavior of business entities, the need to isolate the psychological factors of corporate culture directly affecting the organizational management efficiency is undeniable, since highly professional psychologists and business consultants in this field may contribute to solving problems of organizational interaction. The article analyzes the theoretical background of the corporate culture phenomenon, value orientations and organization in psychological science. The authors’ interpretations of scientific terms from the standpoint of economic, managerial, sociological and psychological approaches are considered. It is noted that corporate culture is driving force of dynamics in organizational changes and collective behavior, which determines the core of activity of the company's functional divisions. Corporate values are a fundamental psychological factor, being in dyadic interaction with each employee’s personal values. Therefore, the employees’ system of career value orientations should be consistent with the company’s system of professional values, for in synergy these are capable of helping the organization improve its efficiency and achieve the desired goal. A comparative analysis of organizational cultures, career and personal value orientations between the representatives of the Ukrainian metallurgical company "Metinvest" and the American telecommunications company "Koscom Cable Inc" was performed. It has been established that internal integration, mutual exchange of knowledge and management experience, and also improvement of the enterprises’ organizational structure should increase the performance of Ukrainian businesses in wartime.
Conflict Competence of Pharmacy Students
Authors: Rybachuk Vasyl , Maievska Nataliia
Published: April 2023

Conflict competence is an integral component of the professional competence of pharmacists and an important characteristic of them as specialists. However, nowadays an insufficient attention is paid to the study of the pharmacists’ conflict competence specifics, and the developed general recommendations for the prevention and regulation of conflict situations do not always take into account the specific conditions that have developed in the pharmaceutical market. The aim of the work is to study the specifics of conflict competence of pharmaceutical students at the stage of professional training in order to develop recommendations for its development. In the empirical study, it was found that the most pronounced personality trait of the tested pharmaceutical students is "Conscientiousness", they are characterized by high motivation and persistence in their attitude to goals and actions. The level of readiness for negotiations and conflict resolution, as well as the level of empathy, is average in the majority of respondents. Pharmacy students, unlike psychology students, have a lower degree of extroversion, empathy for children, for characters in works of art, and for strangers or unfamiliar people, and in a conflict situation, they often resort to compromise. With the help of correlation analysis, the relationship between personality traits and behavior strategies in conflict was revealed. Subjects with the personality trait "Friendliness" in a conflict situation choose the adaptation strategy and avoid rivalry, with the personality trait "Conscientiousness" in the conflict choose the response strategy "Compromise". Ways to optimize the development of conflict competence at the stage of professional training are revealed.
Category of Psychological Security of Personality in Scientific Literature
Authors: Fedchuk Oleksandr
Published: April 2023

In the article, the author reveals the category of psychological safety of the individual in the scientific literature. It was established that there is still no unified point of view regarding the concept of psychological safety and all its prerequisites. Scientists interpret this concept as a dynamic, integral and complex phenomenon, a feeling, experience or state of protection from internal and external dangers, controllability of life events, self-confidence, the ability to maintain balance and resistance to threats, satisfaction with life and basic personal needs, inner peace and a favorable environment for development in the future and its self-realization. The author claims that the main signs of psychological security of an individual are a sense of security and psychological well-being, satisfaction with one's life, confidence in the future, in the possibility of self-realization and self-development, faith in oneself, in one's ability to cope with difficulties in life, relative predictability of changes in the external environment and society. The article reveals three factors that determine personal safety, in particular, the security factor, the environmental factor, and the human factor. The levels of psychological safety and its structure were also analyzed.
To the Question of Attitude to Death of Middle-Aged People During the War in Ukraine
Authors: Yanovskaya Svitlana , Turenko Rimma , Kononenko Nelli , Bilous Natalia , Timchenko Vyacheslav
Published: April 2023

A person's attitude to death is influenced by the critical situations he encounters in his life. The war, which began in Ukraine at the beginning of 2022, made people's feelings about death relevant, because death has become everyday reality in the lives of Ukrainians. The purpose of the study is to determine the peculiarities of middle-aged people attitude to the phenomenon of death during the war in Ukraine. A sample of subjects (N=76) who previously participated in our research in 2019 and 2020 during the coronavirus infection. The age of the subjects varies as follows: Me=44.00; min=35.00; max=55.00. Research methods: the "Attitude to Death" method (I.Yu. Kulagina, L.V. Senkevich), the "Attitude to Death Scale" method by D.V. Hardt, Metaphor of Personal Death technique – the Revised Death Fantasy Scale (RDFS) J. McLennan. It was determined that the attitude towards death in people of the studied middle-aged group during the war is ambivalent with a certain deviation towards the positive. The studied group is characterized by an average level of stress resistance, which is associated with thoughts about death. The choice of metaphors about death is determined by the degree of attitude positivity towards death: a pessimistic attitude towards death is associated with negative thoughts about death, fixation on its external side, avoidance of contact with death. Lack of seeing a positive perspective in death leads to pessimism and negative thoughts. An optimistic attitude towards death is associated with the rare occurrence of negative thoughts about own death, perception of death as a necessary aspect of being, openness to contact with death. Significant differences were found between believers and atheists on the indicator of positive thoughts about their own death: believers showed a high level of acceptance of death. Significant differences in attitudes toward death between men and women were also identified: men have a more positive and "black" humor to thoughts about death.
Socio-Psychological Characteristics of the Suspect's Personal Profile During a Polygraphical Examination
Authors: Kovalchuk Zoriana
Published: April 2023

The article analyzes the expediency and importance of describing the personal profile of individuals during a polygraph survey and ascertaining their involvement in the commission of a crime. Since the field study on the involvement of individuals does not always can give a reliable conclusion, there is a need to create a psychological profile of the individual. A thorough analysis of personal characteristics that are dominant in the profile, a combination of reactions obtained through polygraph examinations and fixed nonverbal manifestations of a person during a polygraph examination, make it possible to conclude that the suspects are involved in the commission of a crime. Only in this case analysis of suspects' profiles can make the most accurate and true conclusion. The results of the conducted research prove that it should be noted that the persons involved in the commission of the crime and persons not involved, the highest figure on the scale of "Reactive aggression". Unrelated to the crime, in contrast to those involved, there is a high rate on the "Irritability" scale, which indicates the presence of emotional instability and the tendency to react to the affective response in order to avoid tension. High rates on the scale of "Emotional lability" are revealed in both groups, but somewhat predominate in persons involved in a crime. It is worth noting that the persons involved in a crime, unlike those who are not involved, are more constrained, uncertain in themselves, rarely show caution in establishing contacts with others, but they seek to expand them. Persons not involved in committing a crime are dominated by respiratory failure, abnormal functioning of the gastrointestinal tract, and sleep problems. They have complicated functioning of attention. There is a feeling of anxiety, which is accompanied by various emotional reactions - shame, anger, guilt, fear.
Should intensive care unit patients get psychotherapy after discharge for Post-Traumatic Stress Disorder (PTSD)?
Authors: Kashif Khan
Published: April 2023

Intensive Care Unit (ICU) patients should get psychotherapy consultations because most of the patients suffer from Post- Traumatic Stress Disorder (PTSD) after discharge, which leads to life-threatening conditions like flashbacks of the events which ultimately results in mood swings and depression. An ICU diary can be used as a form of psychotherapy that can be written by family members and staff everyday. This diary can help the patient during recovery and is useful in their rehabilitation. However, according to a survey on neurotic patients, psychotherapy may not always be effective and can sometimes lead to other problems. People who survive Intensive Care Units have the chance to develop Post-Intensive Care Syndrome (PICS), of which PTSD is also a component.
Effect of warm humidified oxygen on thermoregulation of post-operative patients with abdominal surgery in the selected hospitals of pune
Authors: Jyoti Badade Karande , Meena Ganapathy
Published: April 2023

The majority of surgeries performed in hospitals are related to the abdomen. Many patients develop complications after surgery, and nurses are the primary caregivers for the patients after surgery. Studies have shown that the number of elderly patients with life-threatening abdominal diseases undergoing emergency surgeries is increasing. The common problems arising after surgery performed under general anesthesia are altered thermoregulation and circulatory complications. One of the strategies to reduce post-operative complications related to thermoregulation in abdominal surgery is warm, humidified oxygen intervention. The objectives are to assess the pre-intervention data on thermoregulation in the experimental and control groups, determine the effect of warm humidified oxygen on thermoregulation in the experimental group, assess the post-intervention data on thermoregulation in both groups, and associate the thermoregulation with selected background variables in both groups. The purposive sampling technique was adopted to select the participants. The study comprised 40 patients who fulfilled the inclusion criteria. The research tools included a demographic profile, a shivering score, physiological parameters, and other parameters. The data was analyzed quantitatively in terms of frequency and percentage, mean, standard deviation test, ANOVA test, and Fisher exact test. The findings of the study revealed that the warm humidified oxygen intervention is helpful in increasing temperature and reducing shivering in the experimental group, and the alternative hypothesis is accepted. The study results will be very useful in nursing practice because nurses can use this method to increase body temperature, reduce shivering, help with oxygen saturation, and reduce the incidence of dry mouth.
A study to assess knowledge, attitude, and practice towards major bloodborne diseases and needle-stick injury protocols among second-year nursing students in selected nursing colleges of pune city
Authors: Jyoti Badade Karande
Published: April 2023

Bloodborne pathogens, including Hepatitis B (HBV), Hepatitis C (HCV), and the Human Immunodeficiency Virus (HIV), are infectious microorganisms in human blood that can cause disease in humans. Needle sticks and other sharp related injuries may expose workers to bloodborne pathogens. Workers in many occupations, including first responders, housekeeping personnel in some industries, nurses, and other healthcare personnel, may be at risk for exposure to bloodborne pathogens. The objective of this study is to assess the knowledge, attitude, and practice of second-year nursing students regarding major bloodborne diseases and needle stick injury protocols and to find the association between knowledge, attitude, and practice scores with demographic variables. The quantitative approach to be used is a non-experimental descriptive study, and the sampling method to be used is non-probability purposive sampling. Structured questionnaires, Likert scales, and checklists are used as tools, and statistical methods include Karl Pearson's test for correlation between variables and the chi-square test to test the association. The majority of students have an average level of knowledge, a neutral attitude, and very good practice methods in clinical areas. They also have an average level of knowledge, a neutral attitude, and very good practice skills in clinical areas regarding the prevention and precaution of major bloodborne diseases and needle stick injuries. The correlation between knowledge and attitude scores is found to be negative, while the correlation between knowledge and practice scores is positive and the correlation between attitude and practice scores is negative.
Information Security Management Measures for College Archives Under the Network Environment
Authors: Cui Litao
Published: April 2023

The construction of archives in colleges and universities in China is in the process of development and improvement. With the development information technology, the informatization of college archives has been accelerated. Network technology is developing rapidly in our country, and the number of network users has increased significantly. The use of network technology in university archives management can improve the management efficiency and quality of archives, but the safety factor has dropped significantly. For example, the archival system may face many problems such as virus infection, system paralysis, or cyberattacks, which affects the security of the university archives. Therefore, this paper presents an analysis of these problems in detail, and proposes corresponding solutions, so as to optimize and improve the information security management of college archives.
Global trends from original research on COVID-19 and coinfection
Authors: Moura Maria Eliete Batista , Sousa Neto Antonio Rosa de , Chissamba Rogério Epolua , Carvalho Ana Raquel Batista de , Peres Neris Violeta Gonzalez , Oliveira Thais Alexandre de , Valle Andreia Rodrigues Moura da Costa , Freitas Daniela Reis Joaquim de
Published: April 2023

Introduction: The clinical symptomatology of SARS-CoV-2 and the occurrence of coinfections can be masked by the similarity of the manifestations, thereby delaying the clinical diagnosis and therapeutic decision-making, favoring the worsening of the clinical condition and increasing the chances of death. Aim: to conduct a bibliometric analysis of the world's scientific production on COVID-19 and coinfection in general. Outlining: Bibliometric study with a quantitative approach. Two hundred eight articles were analyzed using the Bibliometrix R package and the Biblioshiny application. Results: The articles were published mainly in 2021 and 2022. The scientific journals that published the most were the Journal of Medical Virology and Cureus. The most cited was the Journal of Medical Virology. The articles were cited 2567 times and addressed the etiology of coinfections, which bacteria, other viruses, fungi, and vectors can cause. Implications: Through this bibliometric analysis, it was possible to identify global trends in research on COVID-19 and coinfection, which in the long term can support the development of new research and the elaboration of strategies aimed at preventing, controlling, and managing cases of coinfections, not only in the pandemic period but continuously.
The Impact of the COVID-19 Pandemic on Tourism in the Tatra County (Poland)
Authors: Druet Paweł
Published: April 2023

The COVID-19 pandemic and the numerous restrictions implemented because of it have had a huge impact on the tourism sector around the world. The aim of this study is to identify and assess their effects on tourism in the Tatra County, the area in which there are some of the most popular tourist places in Poland – the Tatra National Park and the town of Zakopane. The study showed that the COVID-19 pandemic caused a significant decrease in the tourist traffic in this area in 2020, and as a result, a smaller number of incidents requiring the intervention of the Tatra Volunteer Search and Rescue, less demand for accommodation or fewer foreign tourists. In addition, entrepreneurs directly or indirectly involved in the tourism industry recorded lower revenues or losses. Smaller revenues were also recorded in the mentioned town of Zakopane.
De la apicultura fijista a la movilista: Políticas públicas y dinámicas de la modernización del sector apícola español (1867-1980)
Authors: Copena Damián
Published: April 2023

The aim of this paper is to study the process of modernisation of beekeeping in Spain from 1867 to 1980. For this purpose and based on different historical sources such as beekeeping publications, historical statistics, normative documents, and archival documentation, we analyse the process of technological change derived from the appearance of new knowledge that made possible the gradual change from fixism beekeeping to mobilism in beekeeping. The paper presents the two beekeeping models and the public policies and initiatives implemented in Spain for the dissemination of these beekeeping innovations. Finally, the article analyses the main dynamics of the modernisation process in the beekeeping sector. It shows the increase in the number of mobilist hives and the gradual decline in the number of fixist hives, the changes in the geography of the sector and the production dynamics resulting from technological change with an increase in honey production.
TRIPLE-NEGATIVE BREAST CANCER PATIENTS HAVE MORE ABUNDANT MIRNAS PROFILES DERIVED FROM THE PERIPHERAL BLOOD CIRCULATING MICROVESICLES AS A TOOL OF LIQUID BIOPSY
Authors: Braga Letícia da Conceição , Moreira Thayse Batista , Gomes Ana Luiza de Freitas Magalhães , Souza Matheus Gomes de , Salles Paulo Guilherme de Oliveira , Queiroz Fábio Ribeiro
Published: April 2023

Objective: The identification and characterization of miRNAs derived from microvesicles of breast cancer patients is the main goal of this study. Methods: A cohort of 28 patients was evaluated, 28.6% are HER2 overexpressed, 46.4% are triple-negative, and 25% are triple-positive. The study protocol was approved by the Ethics Committee of Instituto Mário Penna (CAEE 82703418.8.0000.5121). For this purpose, the peripheral blood was collected in EDTA tubes and obtained the red blood cell-free plasm. The microvesicles were purified from plasm using the microRNeasy kit (Qiagen) with posterior small RNA precipitation, according to manufacturer’s instructions. The small RNA obtained was used for high throughput sequencing using the QIAseq miRNA Library kit (Qiagen) for library construction, according to manufacturer’s instructions. The sequencing was performed by the Illumina NextSeq 550. The sequences obtained were filtered by quality, the adapters were removed, and small RNA patterns were evaluated using the Unitas (version 1.7.8). Results: The three groups of patients showed a significant abundance of miRNA profiles. The triple-negative breast cancer (TNBC) patients showed the highest relative abundance, which can be due to the more intense exocrine activity of this type of tumor. Furthermore, our results highlighted a great abundance of miR-223-3p in the TNBC patient group. Conclusion: Normally, TNBC patients have an aggressive condition of disease, and cell proliferation, migration, and invasion are common events. These characteristics can be regulated by miRNAs exported from tumor cells in microvesicles. Several miRNAs are already related to these events, and this makes them potential therapeutic or diagnostic targets for this disease. miR-223-3p was previously related to epithelial-mesenchymal transition, cell proliferation, and migration. This phenotypic effect is a strong indication that this miRNA could be used as a biomarker in TNBC management and opens great possibilities for further validation of this as a tool for liquid biopsy tests.
MULTIGENE PANEL TESTING FOR BREAST CANCER PREDISPOSITION IN BRAZILIAN PATIENTS
Authors: Paixão Daniele , Torrezan Giovana Tardin , Santiago Karina Miranda , Formiga Maria Nirvana , Dias Neto Emmanuel , Silva Israel Tojal da , Polak Paz , Carraro Dirce Maria
Published: April 2023

Objective: Only 5–10% of breast cancer (BC) is related to inherited genetic variants, and BRCA1 and BRCA2 mutations are responsible for the majority of cases. BRCA1 is more associated with triple-negative and BRCA2 to the luminal subtype. The contribution of other genes of high and moderate risk for BC, such as TP53, STK11, CDH1, PTEN, ATM, CHEK2, and PALB2, are not well defined, and risk estimates to specific BC subtype are lacking, especially for an admixed population like Brazilian. The aim of this study was to evaluate the contribution of the multigene panel in detecting germline mutations in Brazilian BC patients and their relationship with molecular subtypes and predominant ancestry. Methods: A 94-gene panel was performed on 321 patients with BC fulfilling NCCN criteria who were referred for BRCA1/2 testing between August 2016 and May 2018. Molecular subtypes were retrieved from medical records, and ancestry-specific variants were obtained from the sequencing data. Results: A panel analysis of 321 patients resulted in a total of 83 pathogenic/likely pathogenic (P/LP) variants identified in 81 patients, leading to a positivity rate of 25%. Of the total P/LP variants, 47% were identified in high-risk BC genes (BRCA1/2, PALB2, and TP53) and 17% in moderate-penetrance genes (ATM and CHEK2). The remainders of the variants were identified in low-risk genes and were considered unexpected findings. Variants of uncertain significance were identified in 77.6% of the patients. Regarding the molecular subtype, triple-negative BC had a mutation frequency of 32% (25/79), with predominance in BRCA1 (40%). Among the luminal subtype, 19% (29/155) had P/LP variants, with BRCA1/2 genes contributing to 38% of mutated cases. For the Luminal B HER2-positive subtype, 40% (16/40) had P/LP variants, with a predominance of the ATM gene (37%). Finally, the HER2-enriched subtype presented a mutation rate of 31% (4/13; 1 BRCA2 and 3 non-BRCA1/2). We did not detect any association of ancestry with P/LP variants or molecular subtypes. Conclusion: The multigene panel contributed to identify P/LP variants in other actionable genes besides BRCA1/2, increasing 7.2% of the positivity of the genetic test. Additionally, our results highlight the distinct contributions of BC genes in each molecular subtype. These results indicate that women with clinical criteria for hereditary BC may benefit from multigene panel testing as it allows them to identify P/LP variants in other BC susceptibility genes, including actionable genes, which directly impact the clinical management of these patients and family members.
EARLY-ONSET BREAST CANCER PATIENTS FULFILLING HEREDITARY BREAST AND OVARY CANCER AND LI-FRAUMENI-LIKE SYNDROMES CAN HARBOR TP53 PATHOGENIC VARIANTS
Authors: Silva Paula Francinete Faustino da , Goveia Rebeca Mota , Teixeira Thais Bomfim , Gamba Bruno Faulin , Lima Aliny Pereira de , Rogatto Sílvia Regina , Freitas Júnior Ruffo de , Silveira-Lacerda Elisângela de Paula
Published: April 2023

Objective: We investigate the prevalence of TP53 germline pathogenic variants in a cohort of 83 breast cancer patients and 217 family members from the Midwest Brazilian region. Methods: All patients met the clinical criteria for hereditary breast and ovarian cancer syndrome (HBOC) and were negative for BRCA1 and BRCA2 mutations. Moreover, 40 index patients fulfilled HBOC and the Li-Fraumeni-like syndromes (LFL) criteria. The samples were tested using next-generation sequencing for TP53. Results: Three patients harbored TP53 missense pathogenic variants (p.Arg248Gln, p.Arg337His, and p.Arg337Cys), confirmed by Sanger sequencing. One patient showed a large TP53 deletion (exons 2–11), which was also confirmed. The p.R337H variant was detected in only one patient. Conclusion: This study concluded that 4 out of 83 HBOC and LFL patients presented TP53 pathogenic variants at a young age. In contrast to other Brazilian regions, the TP53 p.R337H variant appeared with low prevalence.
MIR-26A AND MIR-181C PROFILE HIGHLIGHT AS POTENTIAL PROGNOSIS BIOMARKERS IN TRIPLENEGATIVE BREAST CANCER PATIENTS
Authors: Siqueira Bárbara Danielle Silva , Camargos Bianca Nataliene Carvalho de , Freitas Ana Luiza de , Salles Paulo Guilherme de Oliveira , Lucena Clécio Ênio Murta de , Braga Letícia da Conceição , Lopes Luciana Maria Silva
Published: April 2023

Objective: This retrospective cohort study aims to investigate the relative expression profiles of microRNAs (miR 26a, 125b, 181a, 181c, and 340-5p) in patients with triple-negative breast cancer (TNBC) and their relationship with clinical outcome. Methods: We included 10 patients with TNBC, treated at the Mário Penna Institute, Brazil, and 5 patients without TNBC evidence, considered as control. This study was approved by the research ethics committee (CAAE protocol: 39741820.4.0000.9507). The total RNA extraction was performed from the formalin-fixed, paraffin-embedded (FFPE) tissues using the All Prep FFPE (Qiagen™). The RNA concentration was evaluated by the GE NanoVue Plus Spectrophotometer and complementary DNA (cDNA) for each target was synthesized, as appropriate. To analyze the transcripts, the TaqMan real-time PCR technique was used. The small nucleolar RNA RNU6-6P was used as an endogenous control. Changes in miRNA expression were measured by method 2(-ΔΔCq). Results: The expression profile of microRNAs showed a great variability among the TNBC patients, who reinforces the intratumoral heterogeneity of TNBC patients. One of 10 patients showed overexpression of all miRNA evaluated, while 2/10 had underexpression from all of them. An underexpressed profile of miR 181c and 26a was seen in those samples that had a tumor histopathological grade II (3/4) and the overall survival at 1–3 years. In contrast, the overexpression for both miRNAs was seen in 2/10 patients, independent of tumor histopathological grade, with the overall survival at 5–6 years. According to the literature, miR-26a and miR-181c suppressed the expression of MTDH and MAP4K4 genes, respectively, inhibiting the tumor-promoting effects in tumors. Conclusion: Our data appear to highlight the clinical evidence to use miRNAs as new prognosis biomarkers, allowing better stratification of patients. Studies are in progress to evaluate more patients and identify a molecular signature able to predict TNBC prognosis.
DETERMINANTS OF SURVIVAL ON BRAZILIAN PATIENTS WITH BREAST CANCER IN PUBLIC AND PRIVATE PRACTICE
Authors: Frederice Ridania de Oliveira , Pereira Alan Andresson Lima , Andrade Felipe Eduardo Martins de , Hanna Samir Abdallah , Carvalho Heloisa de Andrade , Marta Gustavo Nader
Published: April 2023

Objective: The Brazilian health system can be divided into public and private sectors. In the public sector, insurance is provided by the state to all Brazilian citizens (municipal, state, and federal levels). The private sector is comprised of the private health insurance area, with various schemes of health plans or with out-of-pocket expenses. This study proposed to evaluate the breast cancer population characteristics and treatments according to public and private health care systems. Methods: This retrospective cohort study included patients diagnosed with invasive breast cancer, with health insurance information, between January 2000 and June 2020, from the Fundação Oncocentro de Sao Paulo database. Patients were described according to age, gender, level of education, histology of neoplasm, stage at diagnosis, and type of treatment. Categorical variables are described as percentages and frequencies. The association between demographic and treatment factors and overall survival (OS) was evaluated using a Cox proportional hazard (PH) regression model while accounting for different lengths of participant follow-up. Uni- and multivariable Cox PH models were used to estimate hazard ratios with corresponding 95% confidence intervals for OS. The Kaplan-Meier (KM) curves were used to visually display survival curves, and the log-rank test was used to compare the estimated KM curves. Results: A total of 65,543 patients were included. The distribution by age, gender, and histology was the same for public and private systems. The majority of patients were diagnosed on stages I and II (77.8%) in the private system. However, in the public system, it was found more advanced stage disease (67.8% in stages II and III). Patients with metastatic tumor were more common in the public system (11.1% versus 5.3%). Treatment with surgery and, at least, two types of adjuvant therapy as trimodal therapy were the same in both groups (46.6% private versus 46.2% public). KM plot shows 5- and 10-years OS differences in all stages; 10-year OS in stages I, II, III, and IV in private and public systems were, respectively, 81.6 versus 77.5%, 74 versus 63.3%, 55.6% versus 39.6%, and 7.6 versus 6.4%. In the multivariable analyses, the significant independent predictors for OS were private system, age and stage at diagnosis, high-level education, and trimodal therapy. Conclusion: Older patients, less intensive treatment, and lower educational levels were independent predictors for worse OS. Public health system presented a more advanced stage at diagnosis than private care and was associated with worse survival outcomes in Brazilian breast cancer patients.
Experimental analysis of thermal power plant operating Efficiency Improvements
Authors: Rajeev Sharma
Published: April 2023

Boiler efficiency "The percentage of the total suction heating value of the output steam to the total supply heating value." The main objective of thermal power plants is to meet the energy needs of the market and meet these requirements; Factories need technical availability with parts reliability and maintenance strategies. The current energy situation in India strongly supports the economic security, stability and future development of the country and the social and economic well-being of the people, all of which depend on the wise use of available domestic resources and imported energy. Increasing energy demand. Our future lies in taking extreme measures to combat energy waste caused by the use of inadequate equipment and poor work practices. The industrial and commercial sector of any economy is its pillar. Since they are the main energy users and are few in number, they are easy to approach and target. Thus, they offer a significant opportunity to save considerable energy in their operations by implementing appropriate energy efficiency measures. However, we must not forget that this is a nursery school for developing energy efficient skills as a nation. Moreover, it should not be forgotten that innovation is the key to growth and success. Therefore, we as a nation must think ahead and quickly to utilize the alternative energy sources that exist in our country to utilize our conventional energy sources and use innovative technologies. It is true that boilers are highly desirable for efficient operation / reducing production costs, saving energy and reducing unwanted emissions. If possible, immediate replacement of inefficient boilers should be considered. Here is a review of the following aspects: · Basic Priority Boiler Efficiency and Area Management · Estimate the energy performance of earth boilers and calculate the efficiency. · Factors affecting boiler efficiency · Identification and rational use of alternative renewable energy sources It contains relevant theoretical material and information and is a practical guide for students to identify and implement energy efficiency and savings opportunities in steam boilers. Our project is concerned with determining the current operating efficiency of boilers and calculating the main losses of boilers in thermal power plants. Then determine the reason for the decline in productivity. It also improves boiler efficiency. Boilers are widely used in power generation, chemical and processing industries. This project attempts to explore available methods to maintain and improve boiler efficiency.
Kristus Sang Komunikator Kebenaran: Refleksi Teologi Kontekstual atas Fenomena Hoaks di Media Sosial
Authors: Suroso Yulius
Published: April 2023

Abstract. The media often produces destructive and provocative stories, which can erode and destroy the communal life. This research, which is based on a literature study and observation of digital space phenomena, is an attempt to build a contextual theology to respond to the phenomenon of hoaxes that proliferate in digital media. Through this study, it was revealed that hoax, that appears as half-true news, could be considered as a truth if it is constanly promoted. In dealing with this phenomenon, Christ is an example to be able to discern and confront every available information, so that the truth can be uncovered.Abstrak. Media seringkali memproduksi cerita-cerita destruktif dan provokatif, yang dapat mengikis dan menghancurkan sendi kehidupan bersama. Penelitian yang didasarkan pada studi pustaka dan pengamatan fenomena ruang digital ini adalah sebagai upaya untuk membangun suatu teologi kontekstual untuk menanggapi fenomena hoaks yang menjamur di media digital. Melalui studi ini terungkap bahwa berita bohong, yang sering tampil sebagai berita setengah benar, akan menjadi narasi yang dianggap benar, jika dipromosikan secara terus-menerus. Berhadapan dengan fenomena ini, Kristus menjadi teladan untuk bisa mencermati dan mengonfrontasi setiap informasi yang ada, sehingga kebenaran bisa terungkap ke permukaan.
Síndrome de Zollinger-Ellison: revisión del conocimiento actual
Authors: Beltrán Marcelo A.
Published: April 2023

El síndrome de Zollinger-Ellison se caracteriza por la presencia de úlceras pépticas resistentes al tratamiento que se deben a la hipersecreción ectópica de gastrina por un tumor neuroendocrino, que es el gastrinoma y que resulta en la hipersecreción de ácido clorhídrico en el estómago. Este síndrome se presenta en forma esporádica y también se asocia al síndrome de neoplasia neuroendocrina múltiple de tipo 1. Se describen ambas presentaciones clínicas, así como también la fisiopatología, el diagnóstico, el estudio, el tratamiento y el pronóstico, enfatizando en los detalles técnicos de la cirugía. El pronóstico de los gastrinomas cuando son identificados precozmente es bueno, aun en aquellos casos malignos, por lo que la sospecha clínica asociada al estudio específico y al tratamiento de estos pacientes es fundamental. Dada la tecnología diagnóstica disponible en la actualidad, la identificación de estos tumores será cada vez más frecuente, por lo que el conocimiento de los detalles esenciales para su tratamiento es importante para el cirujano.
The Phenomenon of Division and Modification of The Individual Houses in Baghdad after 2003
Authors: Al- silq Ghada , Salih Amna Basim Mohamed
Published: April 2023

The Research deals with the negative phenomena which appeared in the urban scenes of the  Iraqi cities after 2003, particularly trespassing the architectural design of the urban Individual houses.  Many academic researchers , critics, and cultural circles, drawn attention to the impact of  political and cultural variable change on such phenomena  without detailed  analysis . The research problem  is set according to central questions : If the phenomena is the trespass , whatare the sides which are being trespassed  in the division of the individual house? , If the diagnosis of the phenomena denotes perceived repetition of the cases , So what's size of this transposes on the architectural design of the individual house? , and what are its connections  socially and economically ? The research problem diagnosis by: The lack of knowledge about the impact of the phenomena of trespassing on the architectural design of the individual house specifically?.The research target is to explain the range  of the spreading of trespass in these houses with objective , social , economical investigation, Then clarify the phenomena's impact on the architectural design of individual house in Baghdad. The theoretical frame is built  to extract the research  indicators ( economic, social and  design) theoretically , then  enhance them with the study of the development of the urban house in Baghdad along the 20th century. The indicators were applied on (12) samples were distributed on (2) residential districts, (Palestine Street, AL- Sadr City) which they are various in the residential areasand they different in the social and economic level of the their dwelling, and their houses have modifications and divisions, then find its impact on the designing level of the individual house in Baghdad after 2003. The results showed that both districts in Baghdad houses have this kind of illegal division and (non.efficient , non functional relationship and some of them non ventilation)  , the spread of the phenomenon reflects that there are special details in the methods of division and the modification of the houses ,That should be a widely reviewed  to get to limit this Regulations in precedent phenomena and regain the residential cultural of the city.