bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of financing of free medical care provision state and territorial programs
Authors: Egorova Larisa Vladimirovna , Klunko Nataliya Sergeevna , Regent Tatiana Mihaylovna
Published: October 2023

The article analyzes and compares the financing of expenditures of various types of medical care within the framework of the “Program of state guarantees of free provision of medical care to citizens for 2022 and for the planning period of 2023 and 2024” and the “Territorial program of state guarantees of free provision of medical care to citizens in the Rostov region” for the same periods. Some types of costs for the implementation of state programs in the field of healthcare are considered, due to the implementation of the national project “Healthcare” in the Rostov region and shortcomings in the healthcare system of this region. The growth rates of expenditures of the federal and regional budgets of the Rostov region, as well as the health insurance fund for financing various types of medical care have been determined. The most significant problems in the region that hinder the implementation of state programs included in the national project “Healthcare” have been identified. The budget for healthcare in the region according to regional experts, is not getting bigger, which is an incentive to search for other financing models, in particular, the perspective of the experience of the Rostov region in the field of organization of medical management is noted. In recent years, the municipal authorities have made a decision and transferred all municipal medical institutions to the ownership of the regional government, explaining this by the need to centralize management. The transition of municipal medical institutions to the category of state ones will simplify the routing of patients, make medical care more qualitative and affordable, and also provide an opportunity for more efficient use of all types of resources directed to the field of health care in the region. The results obtained can serve as a basis for adjusting the health policy of the Rostov region.
Identification: problems, trends, methodological aspects
Authors: Tilindis Tatiana Vitalievna , Lazareva Alina Vyacheslavovna
Published: October 2023

For a commercial enterprise, the identification process as an element of the quality and safety assurance system is very important, as well as for consumers who come to a trading organization and choose the right and safe high quality product. Development of methodological aspects of its implementation is relevant. The methods of the process and system approaches used in the research process made it possible to build a logical chain, where identification, as a common denominator between quality and safety, is the dominant link in the process of selling goods at an enterprise, which is ensured by state regulation of system requirements and its components. A unified methodology for all trade enterprises has been developed on the basis of identifying requirements for the identification process and comparing it with the requirements for quality, safety and with the trade technological process. This methodology for the identification process was developed for the first time, which ensures the novelty and significance of the study. The approach to the formation of the methodology was based on the research of various scientists, who partially touched upon the problems of this development, the legal aspects of the problem in general and the reasons for the appearance of negative results of identification, which in turn causes scientific novelty, reflected in the improvement of the methodological approach to solving the problems of trade enterprises associated with ensuring the quality and safety of goods at the stages of acceptance and display. Ultimately, the developed methodology contributes not only to improving the quality of retail trade services at the regional level, but also allows local trade organizations to reach the level retailers from central regions of Russia, especially in the context of change management.
Trends and prospects for logistics development in e-commerce on the example of the last mile delivery of marketplaces
Authors: Viryacheva Evgenia Valer'evna , Treiman Marina Gennad'evna
Published: October 2023

In recent years the volume of online commerce has increased rapidly. The share of online sales is 15% of retail and 30% of non-food retail, and the bulk of online sales (73%) are sales on marketplaces. Logistics is of great importance in online commerce, especially last-mile delivery, which is a complex and expensive component of logistics. Couriers contribute to the formation of the “quality” of the goods for the client, and “traffic jams” and the number of orders complicate the planning process and increase the cost of the service. Currently, last mile delivery is a service with a high level of automation and a high achieved quality standard: delivery at a specified time interval, delivery in 15 minutes, order tracking, delivery with fitting, etc. More recently, marketplaces sacrificed operational efficiency in pursuit of customers and growth indicators. Today, in the absence of Western financing, operational efficiency comes first and many actions of market places are associated with its increase. In logistics, there is a tendency at the last mile to shift the cost of delivery from the marketplace to the end consumer or supplier of goods (depending on the trading conditions chosen by the supplier). The service has become standardized, and marketplaces are beginning to abandon their own delivery services and use outsourcing. It can be assumed that the next step towards improving operational efficiency in large cities will be the zoning of delivery by regions with the allocation of darkstores. It can also be assumed that there will be a unification of the points of delivery of goods of various marketplaces and their approximation to the final consumer.
Benchmarking of the university intellectual products commercialization: experience of innovation-oriented countries
Authors: Pryadko Svetlana Nikolaevna , Vinnik Alina Evgenievna , Dolinskiy Nikolay Ivanovich
Published: October 2023

The article presents brief results of intellectual products of the university commercialization benchmarking at national and regional (local) markets. As the concept of intellectual product of the university we used a generalized indicator that includes all the innovative developments of the university scientists that have the potential to protect intellectual property rights and further commercialization. The objects of benchmarking were the models of commercialization of intellectual products of innovation-oriented countries universities, which are in high positions of the Global Innovation Index: the USA and China. The sources of information for the analysis were secondary information on the research problem, multifunctional search platform for scientific publications Google Scholar, websites of the universities of the countries-leaders of innovative development universities selected as objects of benchmarking. As a result of the studies carried out at the national level the model of China᾿s innovation ecosystem was chosen as a reference sample for further analysis. Indicators for comparative analysis that characterize the process of commercialization of intellectual products at the national market level are the presence of an institutional innovation environment, the presence of a high-tech knowledge-intensive market, innovation spending and the value of companies᾿ intangible assets. At the local level, a multi-company network model for the intellectual products of US universities commercialization was chosen as a reference sample for further analysis. Indicators for comparative analysis are the innovative infrastructure of the university, publication activity of university scientists, indicators of
Factors associated with the combination of general and abdominal obesity in middle-aged and older Korean women: a cross-sectional study
Authors: Ra Jin Suk
Published: October 2023

Objectives: To identify factors associated with general and abdominal obesity in middle-aged and older Korean women based on the biopsychosocial model. Methods: Data from 4,076 women aged ≥45 years who participated in the Korea National Health and Nutrition Examination Survey from 2015 to 2020 were analyzed. Complex sampling analysis was performed using IBM SPSS ver. 26.0. Results: The combination of general and abdominal obesity was positively associated with age ≥65 years, postmenopausal status, and without breastfeeding experience among biomedical factors; depressive symptoms and prolonged (≥8 hours a day) sedentary behavior among psychosocial factors; and an educational level lower than middle or high school graduation and the first and second income quantiles among biosocial factors. Conclusion: Healthcare providers in communities and public societies should screen for risk factors for the combination of general and abdominal obesity while considering non-modifiable biomedical (e.g., age) and biosocial factors (e.g., educational level). In addition, intervention strategies should be developed by considering modifiable psychosocial factors such as sedentary behavior.
Género, imagen y discurso: habla culta de Ciudad de México durante 1960
Authors: Cepeda Ruiz Cristal Yeseidy
Published: October 2023

El presente documento examina la negociación de la imagen social y los roles de género desde el enfoque de la (des)cortesía. Analizamos discursivamente seis intercambios comunicativos grabados en la Ciudad de México de los años de 1960, en los que participan siete mujeres y cuatro hombres cultos entre los 25 y 59 años. Observamos una fuerte adhesión a los roles de género tradicionales entre varones y mujeres mayores, así como algunos cuestionamientos entre mujeres jóvenes y profesionales. Tal patrón se refleja discursivamente: ellas emplean estrategias del rol tradicional femenino (encubrimiento e indirección), y ellos, del papel masculino (actos directos); empero, en eventos confrontativos, ellas utilizan mecanismos directos, y ellos, indirectos y atenuados.
Evaluación de diferentes estrategias para la generación de sistemas de predicción por conjuntos regionales de escala convectiva en un caso de precipitación intensa
Authors: Matsudo Cynthia , Garc´ıa Skabar Yanina , Ruiz Juan Jos´e
Published: October 2023

El pronóstico por conjuntos constituye una metodología consolidada para incorporar la incertidumbre asociada a los pronósticos en diversas escalas espaciales y temporales. En particular, en la mesoescala, no es claro aún cuáles son las técnicas más efectivas para representar la incertidumbre asociada a las condiciones iniciales y a los errores de modelo. En este trabajo se evalúan tres alternativas diferentes para la generación de pronósticos por conjuntos en alta resolución, y se realiza una comparación con un sistema de predicción por conjuntos global de baja resolución. Cada conjunto se construyó con 20 miembros utilizando el modelo WRF-ARW y 4 km de resolución horizontal sobre un dominio que abarca el centro noreste de Argentina. Se explora el desempeño de los conjuntos para un caso de estudio de precipitación intensa entre el 22 y 24 de diciembre de 2015. Los resultados se centran en el análisis del desempeño del pronóstico de precipitación y muestran que los conjuntos en alta resolución tienen mejor desempeño que el sistema global de menor resolución tanto en términos de la precisión del pronóstico como en términos de la cuantificación de su incertidumbre. En este trabajo, los conjuntos donde solo se perturban las condiciones iniciales y de borde tienden a mostrar una menor dispersión que aquellos en donde se combinan diferentes parametrizaciones de los procesos de escala sub-reticular para la representación de los errores de modelo. Estos ´últimos presentan además un menor sesgo para umbrales mayores a 10 mm. Asimismo, aumentar la resolución de las condiciones iniciales y de borde de la media del ensamble aumenta levemente la dispersión y mejora la representación espacial de los patrones de precipitación para todos los umbrales considerados.
Dinámicas de endeudamiento de empresas durante la pandemia y pospandemia COVID-19. La situación de Rafaela y la región
Authors: Ferrero Bruno José , Revale Hernán
Published: October 2023

El trabajo investiga el impacto generado por la pandemia de COVID-19 en las empresas, principalmente en términos financieros y de endeudamiento. A través de un análisis cualitativo exploratorio, se realizaron entrevistas en profundidad a nueve empresas de Rafaela (Argentina) y la región, en su mayoría PyMES industriales de origen familiar. Se investigó la situación de ellas previa a la pandemia, para luego ahondar en cómo esta última repercutió durante el momento de restricción más estricto y después de él.
El análisis muestra que el ecosistema de las empresas entrevistadas de Rafaela (y la región), en general, durante y después de la pandemia, no ha sufrido consecuencias negativas en términos económicos y financieros. La gestión de la crisis, así como el apoyo de las políticas públicas asistenciales, ha permitido atravesar la pandemia sin mayores dificultades y, en muchos de los casos investigados, les ha permitido crecer.
El desempeño laboral de los servidores públicos de la DIGEIM, un análisis desde el clima organizacional
Authors: Ortega Galarza Máximo , Altamirano Pérez Hólguer Rodrigo , Tovar Pinzón María Eugenia
Published: October 2023

La investigación tiene como objetivo determinar la relación existente entre clima organizacional y desempeño laboral de los trabajadores de la Dirección General de Intereses Marítimos de la Armada del Ecuador (DIGEIM). El estudio analiza el clima laboral bajo tres dimensiones: la comunicación interpersonal, la autonomía y la motivación laboral. Por otro lado, el desempeño laboral se estudia bajo las dimensiones de productividad laboral, eficacia y eficiencia laboral. La metodología fue correlacional. Se usaron fuentes primarias mediante la recolección de datos in situ, utilizando como instrumento la encuesta a 64 servidores públicos y aplicando un criterio de medición basado en la escala de Likert para calcular su acuerdo o desacuerdo y proceder a validarlo mediante el Alpha de Cronbach. El principal resultado condujo a establecer la relación directa entre las variables. Para el tratamiento de la información se utilizó el programa SPSS 24.
Trayectorias de formación de profesores de estadística
Authors: Zapata-Cardona Lucía
Published: October 2023

Este artículo estudia las características de las trayectorias de formación de los profesores de estadística. Los participantes fueron siete profesores de estadística en ejercicio de la educación obligatoria que enseñaban en instituciones educativas oficiales en una ciudad al noroeste de Colombia. Se llevó a cabo un estudio de naturaleza cualitativa con enfoque interpretativo. Se utilizó la entrevista a profundidad para reconstruir las narrativas autobiográficas de los participantes y entender las trayectorias de formación que los llevaron a convertirse en profesores de estadística. Los resultados revelaron que los profesores tenían una limitada formación estadística y didáctica, que fueron formados en una tradición donde el conocimiento estadístico era estático y alienante, que enseñaban estadística como un requerimiento de su labor, que tenían prácticas de autoaprendizaje para poder enseñar estadística, y tenían débiles vínculos con asociaciones académicas. Al final se aporta una discusión para pensar la formación de los profesores que enseñan estadística.
EXPLORING THE RELATIONSHIP BETWEEN THE GENERATION Z CONSUMERS’ DESIRE TO LEARN AND OPENNESS TO TECHNOLOGY
Authors: Pânișoară Georgeta , Berceanu Denisa Cristina , Popovici Filip , Sandu Cristina Maria
Published: October 2023

This study explores the relationship between the desire to learn and openness to technology among Generation Z consumers. As a digitally native generation, Generation Z has grown up in an era of rapid technological advancement. This has influenced their attitudes and behaviors towards learning and technology adoption. The aim of this research is to investigate whether there is a correlation between the desire to learn and openness to technology among Generation Z consumers. The research employed a quantitative survey method to collect data from a diverse sample of Generation Z consumers. The survey included measures of desire to learn, openness to technology, and demographic information. Data analysis was conducted using Pearson correlation and regression analysis to explore potential associations between motivation and openness to technology. The results show that Engagement and Desire to Learn are significant predictors for perceived usefulness. Related to the predictors of attitude and intentions to use, results showed that Engagement (R² = 0.19, p < 0.05) and Eagerness to Learn (R² = -0.20, p < 0.05) were predictors for attitude toward mobile apps. On the other side, engagement (R² = 0.17, p < 0.01), fearlessness (R² = -0.21, p < 0.01), and Eagerness to Learn (R² = -0.14, p < 0.05) were significant predictors for the intention to use mobile apps in the future. These findings have important implications for marketers, educators, and policymakers. Understanding the relationship between the desire to learn and openness to technology can help organizations develop targeted strategies to engage Generation Z consumers effectively.
THE IMPACT OF THE NEW TEACHING STRATEGY ON COMMUNICATION IN THE TEACHING OF NATURE AND SOCIETY
Authors: Nikolic Ivko , Sehovic Sefedin , Sadovic Filduza Prusevic
Published: October 2023

The interdisciplinary nature and society teaching provides the teacher with many opportunities in the selection and application of different forms and forms of communication during the teaching process. Depending on the content of learning, the goal and tasks of teaching that we plan to accomplish during the lesson, methods and forms of work, we can plan different forms of communication in teaching. In order to be able to talk about the forms of communication in the teaching of nature and society, we must first know what constitutes teaching communication and what are its basic elements. Social changes in the 21st century require new competencies, and a special emphasis is placed on learning to learn, that is, the development of learning strategies that will equip young people for life and enable their further development through lifelong learning. Since communication is a complex, circular process, in order to better understand it, we must analyze its basic components. A simple communication model consists of the source or sender of the message, the message or the content of the message, the channel or medium for transmitting the message, and finally the recipient as the final destination of the communication process. These four components influence each other in such a way that from the content of the message, the recipient or the medium through which the message is sent, we adapt the other components in order to convey the message in the most effective way.
THE IMPACT OF THE TRAINING METHOD ON STUDENT SATISFACTION: THEORY VERSUS PRACTICE - ONE OF THE MOST CONTROVERSIAL ISSUES IN HIGHER EDUCATION
Authors: Rudnak Ildiko
Published: October 2023

In my study, after a general introduction to the training method, I discuss its important role in higher education and link it to the learning pyramid theory. I will describe the so-called T-subjects integrated in the curriculum of our university (Hungarian Agricultural and Life Sciences University, MATE), which are implemented in the economics majors (bachelor, master and doctoral), and which are present in both our Hungarian and English language economics courses. In the empirical part, I summarise the opinions expressed in the textual reflections of a selected group of students from the Leadership Skills Training in five different classes of international students. The feedback clearly demonstrates that master’s students need both the latest and most up-to-date theories and the skills acquired through experiential learning.
INVESTIGATING THE INFLUENCE OF COVID-19 ETHICS ON STUDENTS’ INTEREST IN LEARNING CHEMISTRY
Authors: NNOLI Juliana Nkiru , Nwafor Stephen Chinedu
Published: October 2023

This study discusses the influence of COVID-19 ethics on students’ interest in learning chemistry. Five research questions and one null hypothesis guided the study. A descriptive survey research design was used to carry out this study. The population for this study consists of 2,644 chemistry Students in the 19 public secondary schools in Awka South Local Government Area of Anambra state. A sample size of 80 chemistry students was used for the study. The simple random sampling method was used to select eight (8) public secondary schools in Awka South Local Government Area. Therefore, 10 chemistry students were selected from each of the eight secondary schools. Twenty (20) item structured questionnaires on a four-point rating scale developed by the researchers were used for data collection. The instrument was validated by two experts. To determine the internal consistency of the instrument, the Cronbach alpha formula was used and a reliability coefficient of 0.87 was obtained. After the administration of the instrument to the respondents, the data obtained were analyzed using mean and standard deviation to answer the research question and z-test to test the null hypothesis at the significance level of 0.05. The findings of the study revealed that social distancing, use of face masks, regular washing of hands, use of hand sanitizers and restriction of movement are common COVID-19 ethics. Also, COVID-19 negatively affected students’ chemistry learning and influences students’ interest to a high extent. It was shown that COVID-19 ethics influenced more of male students’ interest than their female counterparts as there was a significant difference between the male and female chemistry students on COVID-19 ethics on student interest in favour of the males. Thus, providing enough lesson time and provision of ICT and e-learning facilities are possible ways to improve students’ interest in learning chemistry during the COVID-19 era.
AUTONOMOUS LEARNING – A THEORETICAL APPROACH
Authors: Anca Monica Iuliana
Published: October 2023

Autonomy is a pedagogical concept with multiple educational dimensions, the most important correlative notions being involvement, freedom of choice, responsibility, critical thinking, and metacognition. Educational autonomy is a pedagogical concept with multiple educational dimensions, important correlative notions being activation, freedom of choice, responsibility, critical thinking, and metacognition. The common teacher-student actions aim to increase the student's autonomy and include the acquisition of meta-knowledge and the use of meta-cognitive strategies, reflection on knowledge, performing self-evaluations and co-evaluations, combining individual activity with cooperative work activities, and mutual exchanges. The student thus contributes responsibly to his own training, (self) training. The autonomy of the student is objectified in the management of the new knowledge, in setting their own goals and strategies of learning and training, in the hierarchy of priorities, in the design of the strategies of (self) monitoring and self-evaluation, in the curricular management, in the time management. Just like self-education, self-training refers to the conscious, voluntary processes, in which the person undertakes actions aimed, consciously, at qualitative transformations, which lead to the development of his own personality. In self-training, "learning to learn" is essential, understood as the assimilation of cognitive/intellectual and metacognitive skills, contributing to the transformation of self-instruction and self-training into a necessity.
PERCEIVED IMPACT OF MULTIMEDIA TOOLS ON ILESA WEST SECONDARY SCHOOL STUDENTS LEARNING OF ENGLISH LANGUAGE CONCEPTS
Authors: Abanikannda Mutahir Oluwafemi Mukhtar , Ayegbo Temitope Joshua
Published: October 2023

The study Perceived Impact of Multimedia Tools on Ilesa West Secondary School Students Learning of English Language Concepts. The study is a descriptive study; a total number of 300 respondents were used. The instrument for data collections was inventory and was inventory and was structured by the researcher for data collection and reliability level was 0.75. Data collected were analyzed using descriptive statistics specifically mean, standard deviation, frequency counts and Person Product Moment Correlation (PPCM). The findings of the study revealed that Multimedia tools enable you to gain better understanding of English Language concepts that are unclear to you, Multimedia tools give you rom to receive an answer at the same time, as well as being able to exchange responses to questions with teachers in real time, Multimedia tools encourage you to share our thought and opinion on English Language concepts, Multimedia tools develop your critical thinking skills and enrich your learning experience in learning English Language concepts, Multimedia tools help to develop your language skills chiefly English Language, Multimedia tools assist you in comprehending text by utilizing prior knowledge new terminology, Does the appealing features of the multimedia tools allow you to boost your stimulation to the learning process involved in learning English Language concepts, application of multimedia tools in learning English Language also improve memory retention, learning accomplishment and satisfaction. Also, the study has revealed that there is significant difference in learning effectiveness of student who learned English Language concept with multimedia tools and those who learn without it. It also revealed that there is a significant difference in the attitude of secondary school students to learning English Language concepts when multimedia tools are explored and when not. As a result of the findings in this study, this can strengthen the literatures of Multimedia tools.
Diagnostic significance of serum erythropoietin as a marker of perinatal brain damage in premature newborns with very low birth weight
Authors: Sharafutdinova D. R. , Balashova E. N. , Kessler Yu. V. , Vedikhina I. A. , Sukhova Yu. V. , Kirtbaya А. R. , Ryndin A. Yu. , Ivanets T. Yu. , Ionov O. V.
Published: October 2023

The search for promising markers of brain damage in premature newborns is important for the development and optimization of individual diagnostic and therapeutic approaches to neuroprotection in neonatology. Objective: to evaluate the diagnostic significance of serum erythropoietin (sEPO) on the 1st day of life as a marker of perinatal brain damage in premature infants with very low birth weight (VLBW). The study protocol was approved by the Biomedical Research Ethics Committee (Minutes No.12 of 17 November 2016) and the Scientific Council (Minutes No.19 of 29 November 2016) of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V.I. Kulakov of Ministry of Healthcare of the Russian Federation. Written informed consent to the patients' participation in the study was obtained from their parents. The study included 47 premature infants with VLBW born in 2018 at the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of the Ministry of Healthcare of the Russian Federation. In these patients, sEPO was determined on the 1st day of life. Depending on the level of sEPO, infants were divided into 3 groups: group 1 – premature infants with VLBW with a low sEPO level on the 1st day of life (< 20 IU/L, n = 24); group 2 – premature infants with VLBW with an average sEPO level of 20–39 IU/L (reference values) (n = 14) – control group; group 3 – premature infants with VLBW with an elevated sEPO level (≥ 40 IU/L, n = 9). We determined the frequency of brain damage, including intraventricular hemorrhages (IVH) and periventricular leukomalacia. sEPO was not correlated with gestational age. In group 1, IVH ≤ Grade II was observed in 4/24 (16.7%) infants; in group 2, IVH ≤ Grade II was observed in 3/14 (21.4%) infants, and 1/14 (7.1%) infant had IVH Grade III; in group 3, IVH ≤ Grade II was noted in 1/9 (11.1%) infant, and IVH Grade III – in 1/9 (11.1%) infant, p > 0.05. There were no cases of periventricular leukomalacia. A high sEPO level on the 1st day of life in premature infants with VLBW was not associated with an increased risk of perinatal brain damage. The clinical value and practical significance of the determination of sEPO on the 1st day of life as a marker of perinatal brain damage in premature infants with VLBW did not demonstrate any benefits. Further studies are required to assess the role of sEPO in predicting neonatal outcomes.
Reticulocyte hemoglobin content as a marker of iron deficiency in premature newborns with very low birth weight. A simple tool for diagnosing iron deficiency
Authors: Sharafutdinova D. R. , Balashova E. N. , Kessler Yu. V. , Sukhova Yu. V. , Kirtbaya A. R. , Ryndin А. Yu. , Ivanets T. Yu. , Ionov O. V.
Published: October 2023

Reticulocyte hemoglobin content (RET-He) is a promising marker of iron deficiency (ID) in newborns. Objective: to determine the diagnostic value of RET-He as a marker of ID in premature newborns with very low birth weight (VLBW). We conducted a single-center retrospective cohort study, which included 66 premature infants admitted to the National Medical Research Center for Obstetrics, Gynecology and Perinatology named the Academician V.I. Kulakov of the Ministry of Healthcare of the Russian Federation. Data were obtained from January 2016 to December 2018. The gestational age ranged from 29 to 32 weeks. Laboratory examination included blood tests on the 1st and 3rd day of life, then every 10–14 days until the day of life, then every 10–14 days the Institute of Neonatology and Pediatrics;  discharge from hospital, and the measurements of serum iron, ferritin, transferrin on the 7th until the discharge from hospital. This clinical study was approved by the Biomedical Research Ethics Committee (Minutes No.12 of 17 November 2016) and the Scientific Council (Minutes No.19 of 29 November 2016) of the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after the Academician V.I. Kulakov of Ministry of Healthcare of the Russian Federation. RET-He was the highest at birth and declined gradually thereafter in premature newborns reaching the lowest values after 3 weeks of life (median (interquartile range) 28.4 (25.8–34.8) pg (on the 1st day of life – 40.0 (35.7–41.9) pg and 33.5 (29.2–36.6) pg at the time of discharge). A low RET-He level was associated with low reticulocytes, with no changes in hemoglobin. There was a positive correlation between RET-He and MCH. D-He decreased from 1 to 42 days of life as a marker of increasing anemia. There was a negative correlation between RET-He and Hypo-He (p < 0.005). Starting from 42 days of life, or by the time of discharge, 32% of premature infants (n = 21) had a low ferritin level and 77% (n = 51) of premature infants had a low RET-He level, of which 21 infants developed ID (a positive correlation between RET-He and ferritin after 42 days of life (r = 0.34, p = 0.046)). There was no correlation between RET-He and ferritin in newborns without ID. Also, there were no correlations between RET-He and iron and RET-He and transferrin. After 42 days of life, RET-He less than 28.4 pg was a marker of ID (sensitivity 83.3% and specificity 93.7%). Low RET-He, D-He, RBC-Hе and high microR, Hypo-He were the earliest markers of ID in premature infants which predicted a decrease in serum iron and ferritin levels. RET-He, D-Не and Hypo-He are biomarkers with accurate diagnostic value of ID in premature infants with VLBW.
Age-dependent changes in platelet function of a patient with SLFN14-related macrothrombocytopenia
Authors: Rashevskaya E. Yu. , Polokhov D. M. , Fyodorova D. V. , Ignatova A. A. , Ponomarenko E. A. , Raykina E. V. , Mersiyanova I. V. , Poletayev A. V. , Trukhina E. V. , Plyasunova S. A. , Zharkov P. А. , Panteleev M. A.
Published: October 2023

Platelet-type bleeding disorder-20 is a rare inherited thrombocytopenia caused by mutations in the SLFN14 gene. We report a case of a female patient with SLFN14 mutation, macrothrombocytopenia, severe hemorrhagic syndrome and a positive family history who was followed up from the age of 17 to 19. The 3-year follow-up showed a tendency towards partial normalization of platelet counts (from 47 to 82 × 109/L) and morphology. Platelet size and granularity as well as the density of glycoprotein (GP) membrane receptors such as GP Ib/V/IX and GP IIb/IIIa decreased. GP IIb/IIIa activation was impaired and there were no positive changes over time. The dense granules indicators were stably elevated. The parameters of a-granules (assessed by P-selectin expression) did not differ from the control group. The proportion of procoagulant phosphatidylserine-positive platelets at rest was increased and the potential to form procoagulant platelets upon activation was reduced. As the patient grew older, her bleeding disorder symptoms abated and she showed a tendency towards normalization of platelet laboratory parameters. All investigations were performed after obtaining informed consent from the patient and her parents in accordance with the Declaration of Helsinki.
The use of next generation sequencing technologies for the diagnosis of inborn errors of immunity
Authors: Polyakova E. A. , Guryanova I. E. , Vertelko V. R. , Liubushkin A. V. , Skapavets K. Ya. , Aleshkevich S. N , Zharankova Yu. S. , Sharapova S. O. , Belevtsev M. V.
Published: October 2023

Primary immunodeficiencies are congenital genetically determined immune disorders. Recent advances in molecular genetic technologies have enabled a simultaneous analysis of a large number of genes in a patient. The purpose of this study was to analyze the mutational spectrum in DNA samples collected from patients with various types of primary immunodeficiencies. In this study, we applied next-generation sequencing technology using a panel developed at the Belarusian Research Center for Pediatric Oncology, Hematology and Immunology and consisting of 290 genes that are associated with primary immunodeficiencies according to the existing literature. The testing was carried out in 96 patients with a clinical history suggesting a primary immunological defect. As a result, 37.5% of cases (36/96 patients) were found to harbor genetic defects that lead to disorders of the immune system.
Shwachman–Diamond syndrome: a hematologist's view
Authors: Tesakov I. P. , Deordieva E. A. , Brontveyn T. G. , Sveshnikova A. N.
Published: October 2023

Shwachman–Diamond syndrome is a rare genetic disorder with an autosomal recessive inheritance pattern. Most often (in more than 90% of cases) this disease is caused by biallelic pathogenic variants in the highly conserved SBDS gene located on the long arm of chromosome 7. However, approximately 10% of patients with the clinical phenotype of Shwachman–Diamond syndrome lack mutations in SBDS but have pathogenic variants in other genes, such as DNAJC21 or EFL1. Shwachman–Diamond syndrome is a multisystemic disorder characterized by exocrine pancreatic insufficiency, protein-energy undernutrition, delayed physical development, cognitive disorders, anomalies of the skeletal system, and immunological disorders. In addition to the described symptoms, Shwachman–Diamond syndrome is characterized by the presence of bone marrow failure (most often neutropenia and anemia), as well as an increased risk of cytogenetic abnormalities and a predisposition to myelodysplastic syndromes and acute myeloid leukemia. In this review, the authors summarize the spectrum of hematological disorders observed in Shwachman–Diamond syndrome, as well as describe the molecular mechanisms underlying them.
The efficacy and toxicity of L-asparaginase in the treatment of acute lymphoblastic leukemia in children
Authors: Smirnova D. S. , Valiev T. T.
Published: October 2023

L-asparaginase, an enzyme used as an anticancer drug, was one of the first drugs included in the treatment protocols for acute lymphoblastic leukemia. It has become widely used when an important metabolic feature of leukemia cells – their high demand for asparagine to maintain viability – was discovered. Three L-asparaginase preparations are currently used in clinical practice: native E. coli asparaginase, pegylated E. coli asparaginase (PEG-asparaginase), and native E. chrysanthemi-derived asparaginase, which have different half-lives, immunogenic profiles, and the spectrum and frequency of toxic effects. One of the main factors limiting the use of L-asparaginase is its high immunogenicity which can cause acute allergic reactions and the phenomenon of silent inactivation. The development of the immune response leads to an accelerated asparaginase clearance and a shortening of its half-life. To monitor the effectiveness of therapy with L-asparaginase, therapeutic drug monitoring of serum asparaginase activity can be used. When choosing management strategies for patients experiencing acute hypersensitivity reactions to L-asparaginase, the following factors should be taken into consideration: the severity of reaction, the number of previous exposures to L-asparaginase and serum asparaginase activity. The use of PEG-asparaginase is the best first-line treatment strategy for children acute lymphoblastic leukemia, its advantages include a significant reduction in the risk of developing acute allergic reactions, higher therapeutic efficacy and, as a result, improved treatment outcomes.
The prophylaxis of severe hemophilia A with inhibitors in children in the Republic of Belarus: a 12-year experience
Authors: Dmitriev E. V. , Volkova L. I. , Aleinikova О. V. , Liubushkin A. V.
Published: October 2023

The development of inhibitory antibodies against FVIII is the most serious complication associated with the use of FVIII concentrates in hemophilia A patients. There is a need for more research on measures that could reduce the risk of inhibitor formation in previously untreated patients (PUPs) with severe hemophilia A. The purpose of this study was to determine the effectiveness of the prevention of clotting inhibitor development in PUPs (or minimally treated patients) with severe hemophilia A by administering plasma-derived factor VIII concentrate (pdFVIII) at a dose of 25 IU/kg once a week for a year. The study was approved by the Independent Ethics Committee and the Scientific Council of the Belarusian Research Center for Pediatric Oncology, Hematology and Immunology (the Republic of Belarus). Between 2010 and 2022, 56 boys were newly diagnosed with severe hemophilia A. Twenty-one of them received pdFVIII as on-demand treatment to stop bleeding (Group 1). Thirty-five boys received pdFVIII at a dose of 25 IU/kg body weight once a week during the first 50 weeks of treatment for the prevention of inhibitor development (Group 2). The administration of pdFVIII at a dose of 25 IU/kg once a week in the PUPs (or minimally treated patients) contributed to a decrease in the cumulative incidence of inhibitors to 15.9 ± 7.7% (4 out of the 35 patients who had been treated prophylactically) compared with 43.7 ± 11.8% (8 out of the 21 patients who had received hemostatic therapy to stop bleeding) (log-rank test, p = 0.041). Thus, the administration of pdFVIII concentrate at a dose of 25 IU/kg once a week for the first 50 weeks of treatment lead to a decrease (p = 0.009) in the cumulative incidence of inhibitors against the administered coagulation factor VIII to 15.9 ± 7.7%.
A single-center experience of using immunofluorescence staining of blood smears for the diagnosis of hereditary thrombocytopathies
Authors: Yushkova E. V. , Podoplelova N. A. , Fedorova D. V. , Khoreva A. L. , Shcherbina A. Yu. , Zharkov P. A. , Panteleev M. A.
Published: October 2023

The method of immunofluorescence staining of blood smears is a recently developed approach to the remote diagnosis of various platelet pathologies including MYH9 disorders/MYH9-related disease, biallelic Bernard–Soulier syndrome, Glanzmann thrombasthenia, gray platelet syndrome, and others. We report here the experience of introducing this method at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology (Moscow, Russia), which is the main national pediatric hematology hospital that provides diagnosis and therapy to children with blood disorders throughout the country. Our study aimed to transfer this relatively labor-intensive and skill-sensitive method and introduce it into routine laboratory practice, and to perform its validation. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology.
IV jornadas de investigación de la Facultad de psicología y logopedia : Libro de contribuciones
Authors: Rey Peña Lourdes
Published: October 2023

Libro de contribuciones de las ponencias desarrolladas en las IV Jornadas de Investigación de la Facultad de Psicología y Logopedia de la Universidad de Málaga celebradas en este centro durante los días 13 y 14 mayo de 2021. En este libro se presentan los manuscritos completos de algunos de los mejores Trabajos Fin de Grado y Fin de Máster de la Facultad de Psicología y Logopedia realizados en la Universidad de Málaga así como algunos de los trabajos que se están llevando a cabo en diferentes grupos de investigación pertenecientes a este centro
The effects of per- and polyfluoroalkyl substances on environmental and human microorganisms and their potential for bioremediation
Authors: Shittu Adenike R. , Iwaloye Opeoluwa F. , Ojewole Akinloye E. , Rabiu Akeem G. , Amechi Miracle O. , Herve Ouambo F.
Published: October 2023

Utilised in a variety of consumer products, per- and polyfluoroalkyl substances (PFAS) are major environmental contaminants that accumulate in living organisms due to their highly hydrophobic, lipophobic, heat-resistant, and non-biodegradable properties. This review summarizes their effects on microbial populations in soils, aquatic and biogeochemical systems, and the human microbiome. Specific microbes are insensitive to and even thrive with PFAS contamination, such as Escherichia coli and the Proteobacteria in soil and aquatic environments, while some bacterial species, such as Actinobacteria and Chloroflexi, are sensitive and drop in population. Some bacterial species, in turn, have shown success in PFAS bioremediation, such as Acidimicrobium sp. and Pseudomonas parafulva.
Aronia Melanocarpa Fruit Juice Ameliorates the Histopathological Changes in the Myocardium and Coronary Arteries in a Rat Metabolic Syndrome Model
Authors: Reyzov M. , Tzaneva M. , Eftimov M. , Gancheva S. , Todorova M. , Valcheva-Kuzmanova S.
Published: October 2023

Aim:

The purpose of this study was to examine the effect of Aronia melanocarpa fruit juice (AMFJ) on the histology of the myocardium and coronary arteries in metabolic syndrome (MS) rats.

Materials and methods:

The animals were divided into five groups: control, MS, MS+AMFJ2.5, MS+AMFJ5, and MS+AMFJ10. For 10 weeks, the control group received regular rat chaw and tap water, the other groups – high-fat, high-fructose diet and 10% fructose in their drinking water to induce MS. Throughout the experiment, rats received a daily oral treatment: the control and MS groups – 10 ml/kg distilled water, the other groups – AMFJ at doses of 2.5, 5.0, and 10.0 ml/kg, respectively. At the end of the experimental period, the animals were sacrificed and tissue samples from the myocardium and coronary arteries were evaluated histologically.

Results:

In the MS group, degeneration of the cardiomyocytes and endothelial cell necrosis were detected. In the MS+AMFJ2.5 group, cardiomyocyte damage was decreased, the endothelium was damaged and the preserved cells were activated. In MS+AMFJ5 and MS+AMFJ10 groups, the myocardium and the endothelial layer of the coronary arteries were preserved.

Conclusion:

These results indicate cardio- and vasoprotective effects of the juice.
Pharmaceutical Regulation of Herbal Medicinal Products in the Countries of the European Union, the USA, Canada and Japan
Authors: Hadzhieva B. , Dimitrov M. , Petkova V.
Published: October 2023

The regulation of herbal medicines is changing and alters in the different countries. The Federal Food, Drug, and Cosmetic Act (FD&C Act) defines medicines on the grounds of their intended use. Medicines shall be preliminarily approved by the FDA prior to their placing on the market or if they are OTC – they shall meet the requirements of specific regulations, called monographs, for their category. The definition of medicine according to the Canadian Food and Drugs Act (R.S.C., 1985, c. F-27) is “any substance or a combination of substances manufactured, sold or made available for use”. In Japan, the objective of the Medicines and Medical Products Act is to improve public health by means of regulations that are necessary to guarantee the quality, the efficiency and the safety of medicines, quasi-drugs, cosmetics, medical and medicinal products. The definition of a medicinal product in the EU has been specified in Section I Definitions of Directive 83/2001/EC. In the aforementioned countries under consideration, medicines are classified into: medicines prescribed by a doctor (POM) and medicines sold without a doctor’s prescription (OTC). The conducted comparative analysis of the aforementioned countries has shown that there are specific requirements and regulations for herbal medicinal products in the European Union. In the USA and Canada, herbal medicinal products are regarded as a subsection of the Federal Food, Drug, and Cosmetic Act (FD&C Act), sec. 351-360n-1 U.S.C. 379e; the Food and Drugs Act (R.S.C., 1985, c. F-27) – Government of Canada. In the Japanese legislation, there are no specific requirements for herbal medicinal products.
Development of the financial situation of Hungarian food industry enterprises – changes between 2017 and 2021
Authors: Hegyi Judit , Troján Szabolcs , Kacz Károly , Varga Anita Miklósné
Published: October 2023

Subject and purpose of work:

The aim of the study is to analyse how the main financial data of d ouble-entry b ookkeeping f ood p rocessing e nterprises r eflect t he e ffects o f t he i ndicated economic environment.

Materials and methods:

The evaluation was fundamentally based on ratios calculated on the basis of the statement of financial position and the income statement as well as trend analysis and financial indicators.

Results:

The number of Hungarian food processing enterprises has been gradually decreasing over the period under review. Both turnover and expenditure show linear growth at current prices, with increases in the various result categories. The asset structure is stable, and profitability is improving.

Conclusions:

The number of companies and the employment in the sector have been steadily declining in recent years, while efficiency is increasing. The increase in profits in the food industry is remarkable for all branches of the economy. The sector is adapting well to the negative effects of the changing economic environment.
WIBOR, WIRON, WIBID, POLONIA as reference rates for bank loans
Authors: Król Patryk
Published: October 2023

The paper discusses issues connected with the use of selected indices (WIBOR, WIBID, WIRON, POLONIA) as benchmarks for bank loans. In the introduction, the author addresses the problem of manipulation of rates, which are characterized by the forecasting of interest rate values. The following part of the paper analyses the differences in benchmarks’ construction, describes their operation, methods of setting and use. It also outlines their behavior over time. Subsequently, issues relating to the application of WIBOR, WIBID, POLONIA, WIRON as benchmarks for consumer loans are presented. They have been compared to a sample bank offer based on a fixed interest rate. The final conclusions outline the possible effects of various benchmarks on borrowers, and compare the situation of the Polish banking offer for fixed-rate loans with other countries. The possible effects of new regulations in the context of the share of fixed-rate loans in the credit market are also described.