bluuebunny/crossref_metadata_2025 huggingface dataset:
A Systematic Review of Neurovascular Complications in Patients with Pseudoxanthoma Elasticum
Authors: Domzalski Colin , Wei Nancy , Lebwohl Mark
Published: November 2020

Background: Pseudoxanthoma elasticum (PXE) is a rare, hereditary connective tissue disorder characterized by ectopic calcification of multiple organ systems. Cardiovascular complications secondary to accelerated atherosclerosis are well-documented in published literature; however, there is a paucity of studies that reviews serious neurovascular complications including CVA(cerebral vascular accident), TIA(Transient ischemic attack), and intracranial aneurysm development in PXE patients.  
Objective: We aim to review current literature reporting cases of serious ischemic and hemorrhagic neurovascular complications in PXE patients as of September 2020 and reexamine current guidelines on anticoagulation and antiplatelet therapy in PXE patients
Methods: A search of the PubMed database limited to English language case reports using the key words “pseudoxanthoma elasticum”, “neuro*”, “cerebr*”, “CVA”, “TIA”, and “aneurysm” was performed.
Results: A total of 67 cases of cerebral disease were reported; ranging from ages 2-71 years from 12 countries. The most common neurovascular complication seen was ischemic strokes (68.7%) followed by TIAs (20.8%), intracranial aneurysms (6.0%) and lastly hemorrhagic strokes (4.5%).
Conclusions: PXE patients have a greater incidence of ischemic strokes compared to the general population. Clinicians should thus carefully weigh the benefits of anticoagulation therapy in patients with known cardiovascular disease against the risk of bleeding.
Complete Histologic Response of Regionally Metastatic Melanoma Treated with Intralesional Interleukin 2, Topical Retinoid and Imiquimod
Authors: Schaffenburg William , Davis Joshua , Logemann Nicholas , Simpson Meagan
Published: November 2020

Abstract not available.
Integrating Metagenomics into Personalized Medicine in Dermatology
Authors: Huang Amy , Glick Sharon
Published: November 2020

There has been a recent focus on the association between human microbiomes and disease development, disease resistance, and therapy response. Fecal transplants for inflammatory bowel disease and resistant Clostridium difficile infection have demonstrated that manipulating the gut microbiome can be beneficial in treating disease. Microbiomes are important in dermatology, where response to immune checkpoint inhibitors for melanoma therapy can be affected by differences in gut microbial composition. Bleach baths, which alter the skin microbiome, are known to be beneficial in atopic dermatitis. Gut dysbiosis, or disturbance in the gut microbiome in early life, can influence the development of systemic sclerosis and atopic dermatitis. Metagenomic sequencing can therefore be a useful addition to personalized medicine to identify therapy responders versus non-responders, patients at risk of serious side-effects from biologics and immune checkpoint inhibitors, and prebiotic supplements that aid in improving therapy response.
A Cross-Sectional Study on Herpes Zoster Diagnosis in the time of COVID-19
Authors: Nourmohammadi Niki , Yale Katerina , Ghigi Alessandro , Zheng Kai , Mesinkovska Natasha
Published: November 2020

Background: COVID-19 infections have presented with various cutaneous manifestations in COVID-19 positive patients, including reports of rising cases of herpes zoster (HZ).  
Objective: Our investigation sought to investigate the proposed association between a positive COVID-19 test result and herpes zoster infection as well as determine whether the COVID-19 pandemic has affected the overall incidence of HZ.
Methods: In this cross- sectional study, de-identified patient data was collected from the University of California COVID Research Data Set (UC CORDS), a centralized, rapidly accumulating database of COVID-19 tested patients. Patients were divided into those diagnosed with HZ before COVID test and those with HZ after COVID testing. The University of California Health Data Warehouse was then used to collect the total number of HZ cases from March to August in 2019 and 2020 to calculate and compare the HZ condition rate.
Results: A total of 608 patients were diagnosed with HZ from March 1 to August 31, 2020; of which, 2.1% (n=13) tested positive for COVID-19. From March to August 2019 there were 4,349 reported HZ cases, and in comparison, there were 3,551 reported cases of HZ in 2020, a significant decrease (χ2 =90.6454, p<.00001).
Conclusion: In this limited dataset, there was no evidence to substantiate an association between HZ and COVID-19 infection, nor was there an increase in the number of cases of HZ during the time of the COVID-19 pandemic.
Dupilumab Provides Acceptable Long-Term Safety and Efficacy in Children Aged ≥ 6 to < 12 Years with Uncontrolled, Severe Atopic Dermatitis
Authors: Cork Michael , Thaçi Diamant , Eichenfield Lawrence , Arkwright Peter , Chen Zhen , Kamal Mohamed , O'Malley John , Bansal Ashish
Published: November 2020

Abstract not available.
Reduced Blood-brain Barrier Penetration of Sarecycline Relative to Minocycline in Rats Corresponds with Lipophilicity and Low Vestibular Side Effects
Authors: Stein-Gold Linda , Moore Angela , Tanaka S. Ken , Johnson Jodi , Grada Ayman
Published: November 2020

Abstract not available.
Combining DNA and RNA Analyses Enhances Non-Invasive Early Detection of Cutaneous Melanoma
Authors: Cullison Stepnaie , Ferris Laura , Yao Zuxu , Ibarra Claudia , Howell Michael , Jansen Burkhard
Published: November 2020

Abstract not available.
Dose Adjustment Patterns in the Open-Label Extension Arms of Three Phase 3 Trials of Certolizumab Pegol in Psoriasis: CIMPASI-1, CIMPASI-2, and CIMPACT
Authors: Blauvelt A , Gottlieb AB , Fierens F , Brock F , Wiegratz S , Sofen H
Published: November 2020

Abstract not available.
A study on legal and medical dimensions of radiation exposure in neurosurgery clinics in Turkish practice
Authors: Karaarslan Abdulkadir , Kasim Fatma Bahar Hacioğlu , Karaarslan Numan , Ates Ozkan
Published: November 2020

Background:

In the present study, the first aim was to address the detrimental effects of the fluoroscopy procedure performed by physicians and other health-care professionals in neurosurgery clinics, then to examine precautions that should be taken to avoid harmful effects of radiation and radioactive substances during this process. The second aim was to handle the rights provided for health-care professionals exposed to the radiation in workplaces.

Methods:

A standardized questionnaire was used for a multicenter survey. Volunteer, intellectual, and cooperative participants (n = 41) were randomly chosen. The survey was prepared considering reports drawn up by the International Atomic Energy Agency. The questions concerning safe and effective fluoroscopy procedure were asked to the participants. The answers received were statistically evaluated. The alpha significance value was accepted as 0.05.

Results:

Two neurosurgeons only knew the legal rights that they might possess due to the exposure to the radiation or radioactive substances.

Conclusion:

The survey conducted among the health-care professionals revealed the insufficiency of knowledge about the protection from the radiation exposure or radioactive substances in workplaces. Furthermore, both health-care professionals working in radiology clinics, and those in neurosurgery and other clinics who are likely to be exposed to the radiation or radioactive substances have the rights afforded by the law.
Use of Thin Dressings Under N95 Respirators: Exploring Their Effect on Quantitative Fit Testing Results to Guide Hospital Practice During the COVID-19 Pandemic
Authors: Guschel Susan , Chmiel Karen , Rosenstein Jennifer
Published: November 2020

At the beginning of the coronavirus disease-19 pandemic, health care staff at a level 1 trauma center in the state of New York experienced facial irritation and skin breakdown under their N95 respirators due to increased and prolonged use. PURPOSE: Members of the Certified Wound and Ostomy Nurse, Nurse Practitioners staff were charged with developing recommendations within 48 hours to help prevent and manage facial skin issues using available products that would not compromise the seal of the respirators. METHOD: With the assistance of a health care safety specialist from the Environmental Health and Safety Department of the hospital, an ambient particle counting device was used to measure the N95 fit factor following application of a liquid skin barrier, transparent film dressing, light silicone-based adhesive dressing, or an extra-thin hydrocolloid dressing on the bridge of the nose and the cheekbones underneath an N95 respirator of 2 hospital staff members who volunteered to test the dressings. RESULTS: All thin dressings tested showed a fit factor over 100, reflecting an effective seal. The highest fit factors were seen with the liquid skin barrier in the 2 volunteers (200 and 198, respectively). Thin dressing usage information was included in the hospital guidelines for N95 respirators and shared with staff. Subsequent feedback suggests that the light silicone-based adhesive dressing and the extra-thin hydrocolloid dressing were preferred. CONCLUSION: Thin dressing use may help reduce skin complications among hospital staff during periods of extended N95 respirator wear time. Because use of the dressings did not result in failure of the quantitative fit test, they were permitted for use by health care staff under their N95 respirators. Studies are needed to help health care facilities optimize N95 respirator use to protect staff from coronavirus disease-19 and respirator-related skin complications while supply shortages remain.
Shipworm symbiosis ecology-guided discovery of an antibiotic that kills colistin-resistant Acinetobacter
Authors: Miller Bailey W. , Lim Albebson L. , Lin Zhenjian , Bailey Jeannie , Barrows Louis R. , Manoil Colin , Schmidt Eric W. , Haygood Margo G.
Published: November 2020

Teredinibacter turnerae is an intracellular bacterial symbiont that lives in the gills of wood-eating shipworms, where it is proposed to use antibiotics to defend itself and its animal host. Several biosynthetic gene clusters are conserved in T. turnerae and in their host shipworms around the world, implying that they encode the important defensive antibiotics. Here, we describe the turnercyclamycins, lipopeptide antibiotics encoded in the genomes of all sequenced T. turnerae strains. Turnercyclamycins A and B are bactericidal against challenging Gram-negative pathogens, including Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii, at 1, 2, and 8 µg/mL, respectively. Additionally, these compounds kill colistin-resistant Acinetobacter strains, while lacking toxicity to mammalian cells. Phenotypic screening identified the outer membrane as the likely target. By exploring the inhabitants of environments that select for the properties we require, we can harvest the fruits of evolution to discover compounds with potential to target unmet health needs. Investigating the symbionts of animals, and shipworms in particular, is a powerful example of this principle.
Molecular Docking of Olea europaea and Curcuma Longa Compounds as Potential Drug Agents for Targeting Main-Protease of SARS-nCoV2
Authors: Saif Rashid , Raza Muhammad Hassan , Rehman Talha , Zafar Muhammad Osama , Zia Saeeda , Qureshi Abdul Rasheed
Published: November 2020

One of the main reasons of rapidly growing cases of COVID-19 pandemic is the unavailability of approved therapeutic agents. Therefore, it is urgently required to find out the best drug/vaccine by all means. Aim of the current study is to test the anti-viral drug potential of many of the available olive and turmeric compounds that can be used as potential inhibitors against one of the target proteins of SARS-nCoV2 named Main protease (Mpro/3clpro). Molecular docking of thirty olive and turmeric compounds with target protein was performed using Molecular Operating Environment (MOE) software to determine the best ligand-protein interaction energies. The structural information of the viral target protein M pro/3CL pro and ligands were taken from PDB and PubChem database respectively. Out of the thirty drug agents, 6 ligands do not follow the Lipinski rule of drug likeliness by violating two or more rules while remaining 24 obey the rules and included for the downstream analysis. Ten ligands from olive and four from turmeric gave the best lowest binding energies, which are Neuzhenide, Rutin, Demethyloleoeuropein, Oleuropein, Luteolin-7-rutinoside, Ligstroside, Verbascoside, Luteolin-7-glucoside, Cosmosin, Curcumin, Tetrehydrocurcumin, Luteolin-4'-o-glucoside, Demethoxycurcumin and Bidemethoxycurcumin with docking scores of -10.91, -9.49, -9.48, -9.21, -9.18, -8.72, -8.51, -7.68, -7.67, -7.65, -7.42, -7.25, -7.02 and - 6.77 kcal/mol respectively. Our predictions suggest that these ligands have the potential inhibitory effects of M pro of SARS-nCoV2, so, these herbal plants would be helpful in harnessing COVID-19 infection as home remedy with no serious known side effects. Further, in-silico MD simulations and in-vivo experimental studies are needed to validate the inhibitory properties of these compounds against the current and other target proteins in SARS-nCoV2.
Activation of Ammonia and Hydrazine by Electron Rich Fe(II) Complexes Supported by a Dianionic Pentadentate Ligand Platform Through a Common Terminal Fe(III) Amido Intermediate
Authors: Nurdin Lucie , Yang Yan , Neate Peter , Piers Warren , Maron Laurent , Neidig Michael L. , Lin Jian-Bin , Gelfand Benjamin S.
Published: November 2020

We report the use of electron rich iron complexes supported by a dianionic diborate pentadentate ligand system, B2Pz4Py, for the coordination and activation of ammonia (NH3) and hydrazine (NH2NH2). For ammonia, coordination to neutral (B2Pz4Py)Fe(II) or cationic [(B2Pz4Py)Fe(III)]+ platforms leads to well characterized ammine complexes from which hydrogen atoms or protons can be removed to generate, fleetingly, a proposed (B2Pz4Py)Fe(III)- NH2 complex (3Ar-NH2). DFT computations suggest a high degree of spin density on the amido ligand, giving it significant aminyl radical character. It rapidly traps the H atom abstracting agent 2,4,6-tri-tert-butylphenoxy radical (ArO•) to form a C-N bond in a fully characterized product (2Ar), or scavenges hydrogen atoms to return to the ammonia complex (B2Pz4Py)Fe(II)-NH3 (1ArNH3). Interestingly, when (B2Pz4Py)Fe(II) is reacted with NH2NH2, a fully characterized bridging diazene complex, 4Ar, is formed along with ammonia adduct 1Ar-NH3 as the spectroscopically observed (-78˚C) (B2Pz4Py)Fe(II)-NH2NH2-Fe(II)( B2Pz4Py) dimer (1Ar)2-NH2NH2 is allowed to warm to room temperature. Experimental and computational evidence is presented to suggest that (B2Pz4Py)Fe(II) induces reductive cleavage of the N-N bond in hydrazine to produce the Fe(III)-NH2 complex 3Ar-NH2, which abstracts H• atoms from (1Ar)2-NH2NH2 to generate the observed products. All of these transformations are relevant to proposed steps in the ammonia oxidation reaction, an important process for the use of nitrogen-based fuels enabled by abundant first row transition metals.
İntravenöz Katater Uygulamasında Kullanılan Kelebek Desenli Tespit Malzemesinin Çocukların Emosyonel ve Fizyolojik Göstergelerine Etkisi
Authors: BURUNSUZ Ezgi Gamze , KÖSE Selmin
Published: November 2020

Amaç: Bu araştırma intravenöz katater uygulamasında kullanılan tespit malzemesinin çocuğun emosyonel ve fizyolojik göstergelerine etkisini belirlemek amacıyla gerçekleştirildi.
Materyal ve Metot: Örneklem grubunu 30 deney, 30 kontrol grubu olmak üzere toplam 60 çocuk oluşturdu. Veriler, Çocuk ve Ebeveyni Tanılama Formu, Çocuklarda Emosyonel Göstergeler Ölçeği, Vital Bulgu Değerlendirme Formu kullanılarak toplandı. Verilerin değerlendirilmesinde uygun istatistiksel analizler kullanıldı. Deney grubuna renklendirilmiş desenli, kontrol grubuna ise rutin bakımda kullanılan beyaz renk tespit malzemesi kullanıldı. Bulgular: Deney grubundaki çocukların tespit öncesi, tespitten sonra birinci ve beşinci dakikada ölçülen oksijen saturasyonu ortalamalarının çok yakın olduğu, kontrol grubunda ise tespit sonrası birinci ve beşinci dakikada en yüksek seviyeye ulaştığı belirlendi. Deney grubundaki çocukların emosyonel puan ortalamalarının, kontrol grubundan daha düşük olduğu saptandı (p<0,05).
Sonuç: Renklendirilmiş desenli tespit malzemesi ile çocuğun dikkatinin başka yöne çekilmesi fizyolojik ve emosyonel göstergeler üzerinde olumlu etki yapmıştır. Çocuklarda IV katater yerleştirme sonrası kullanılan renklendirilmiş desenli tespit malzemesinin çocuk servislerinde kullanımının yaygınlaştırılması ve farklı yaş ve hastalık gruplarında fazla sayıda örneklemin olduğu çalışmalarda etkinliğinin araştırılması önerilir.
Origin and integration: a study of migrants in the 2016 Irish Census
Authors:   ESRI, McGinnity Frances , Privalko Ivan , Fahey Éamonn , O'Brien Doireann , Enright Shannen
Published: November 2020

Many migrant groups have higher educational attainment but higher unemployment levels, according to a new ESRI study.
Editorial: What is the future of the endovascular treatment of intracranial aneurysms?
Authors: Pierot Laurent
Published: November 2020

Intracranial aneurysms rapture is a common cause of mortality or morbidity worldwide. For this reason, in case of rupture, early treatment of the aneurysm is mandatory. The evaluation of unruptured intracranial aneurysms continue to increased due to the improvements in invasive and non-invasive neuroimaging. Securing of this life-threatening condition, considering all demographical and procedural factors is necessary for improving treatment results and patients outcome. The endovascular treatment has become frontline therapy of cerebral aneurysms treatment during the last 20 years, and without a doubt its recent advances shifted this boundary even further. Nowadays endovascular armamentarium continues to grow rapidly. Neuro-interventional procedures have tremendously improved their efficiency and continue to improve device’s safety. However some types of aneurysms are not really easy to treat with ordinary endovascular technique as it can result in devastating consequence, Firstly, it is not always applicable to complex aneurysms or very large neck aneurysms. Secondly, durability of the of the aneurysm occlusion is not guaranteed in all cases even after usage of the remodeling technique or regular stenting. New devices are introduced to decrease these limits. Two new innovative techniques that are increasingly used for endovacular occlusion of the complex aneurysms are flow diversion and intrasaccular flow disruption. The objective of this review is to provide a comprehensive overview of novel paradigms and latest research of flow diversion and intrasaccular flow disruption devices, its current application, limitation and future prospective. The obvious advantages of these new technologies proved progressive expansion of their utilization to the extent that they will ultimately replace standard coiling in an increasing number of cases going forward. The future of the endovascular treatment of intracranial aneurysms is bright. Fast gro-wing improvement in vascular access, treatment modalities and device delivery continue to increase number of patients with intracranial aneurysms treated with endovascular approach versus surgical clipping.
Complejidad ontológica y enunciados de problemas matemáticos
Authors: Oxley Insfrán Víctor Manuel
Published: November 2020

El contexto común, que condiciona la práctica escolar de la resolución de problemas matemáticos, contempla el paso de la enunciación verbal (oral escrita o pictográfica), es decir de la enunciación general (lingüística por lo común) del problema a su resolución en lenguaje matemático; este proceso no es para nada automático, inmediato ni transparente, pues está determinado por lo que denominamos grado de complejidad ontológica -proceso que condiciona la comprensión (interpretación) en términos matemáticos de lo que se plantea- desde el lenguaje coloquial. La complejidad ontológica hace referencia a la oración gramatical en cuanto a su estructura lógica. Esta propuesta teórica postula la fórmula -que denominamos índice de complejidad ontológica (CO)-, como cociente al número que se refiere a la cantidad total de variables que contiene el o los predicados de las proposiciones y el denominador al número total de relaciones entre las variables de los predicados. Se puede usar esta fórmula para la cualificación de los ejercicios en cuanto a la cantidad de referentes y de sus relaciones –contenido ontológico- proporcionándose así una herramienta que brinda otra perspectiva para la labor pedagógica en el aula. Esta investigación, es metaanalítca, se estudian las bases de datos del Tercer Estudio Regional Comparativo y Explicativo TERCE (de la Organización de las Naciones Unidas para la Educación, la Ciencia y la Cultura – UNESCO - Oficina Regional de Educación para América Latina y el Caribe) en lo que respecta a los resultados de los niños del tercer grado de la Educación Escolar Básica del Paraguay, encontrando que el 73% de estos, agrupados en los niveles IV y III de competencia matemática, también alcanzaron el Nivel IV en Lectura, esto lleva a pensar que los niveles superiores de competencia matemática están asociados a los niveles superiores de competencia lectora (lenguaje).
High rates of metallo-beta-lactamase-producing Klebsiella pneumoniae in Greece - a review of the current evidence
Authors: Vatopoulos A
Published: November 2020

For the last four years Greece has faced a large number of infections, mainly in the intensive care units (ICU), due to carbapenem-resistant, VIM-1-producing Klebsiella pneumoniae. The proportion of imipenem-resistant K. pneumoniae has increased from less than 1% in 2001, to 20% in isolates from hospital wards and to 50% in isolates from ICUs in 2006. Likewise, in 2002, these strains were identified in only three hospitals, whereas now they are isolated in at least 25 of the 40 hospitals participating in the Greek Surveillance System. This situation seems to be due to the spread of the blaVIM-1 cassette among the rapidly evolving multiresistant plasmids and multiresistant or even panresistant strains of mainly K. pneumoniae and also other enterobacterial species. However, the exact biological basis of this phenomenon and the risk factors that facilitate it are not yet fully understood. Moreover, the fact that most strains display minimum inhibitory concentration (MIC) values below or near the Clinical Laboratory Standard Institute (CLSI) resistance breakpoint create diagnostic and therapeutic problems, and possibly obstruct the assessment of the real incidence of these strains.
Language learning strategies (SILL) for foreign langauge learners: A sample from Gagavuzia
Authors: KÜÇÜKLER Halil
Published: November 2020

Learning strategies and their usage arebrought under notice when studying about learners who study English as a Foreign Language (EFL). The learning strategies have been investigated for more than 35 years using various elicitation tools and methods. The objective of this study is to identify the learning practices of students who are learning their second languages at Foreign languages and Culture Faculty in State University in Gagavuzia in the academic year 2019-2020 concerning the use of learning strategy inventory.The survey plays a significant role in helping educators to check the learners' awareness of the subject under discussion. A quantitative study was conducted at Foreign languages Department in Komrat State University in Gagavuzia in the academic year 2019-2020 to examine and weigh the use of Strategy Inventory for Language Learning,(Oxford;1990). 581(182 female 399 male) students answered the questionnaire. After the questionnaire was completed, the common strategies of the group were identified as male and female under analysing gender. From the results of the study, it is clear that the foreign language learners both male and female, heavily rely on the learning strategies to boost their memory and mastery of vocabularies. However, the degree of use of the strategies significantly differs. The participants' attitudes towards the use of SILL learning strategies also vary based on the learning environment that they are exposed to. As such, SL educators should try to create a positive learning environment, especially for SL students, to enhance their learning capacities.
Student’s motivation to pursue a graduate-entry medicine degree programme
Authors: Kumar Sonia , Browne Rachel , Wu Jeffrey , Tso Simon
Published: November 2020

The decision to pursue medicine is a significant step for individuals, particularly those for whom this involves a career change. While medicine in the UK has traditionally been an undergraduate course, graduate-entry medicine (GEM) programmes were introduced in 2000 and offer an accelerated course for suitably qualified candidates with a Bachelor’s degree. Students have a variety of motivations for undertaking a GEM programme (Carter & Peile, 2007), and we herein explore the factors that influence this range of motivations.
Development of a 3-dimensional printed tube thoracostomy task trainer: An improved methodology
Authors: Chen Wen Hao , Radzi Shairah , Chiu Li Qi , Yeong Wai Yee , Mogali Sreenivasulu Reddy
Published: November 2020

Introduction: Simulation-based training has become a popular tool for chest tube training, but existing training modalities face inherent limitations. Cadaveric and animal models are limited by access and cost, while commercial models are often too costly for widespread use. Hence, medical educators seek a new modality for simulation-based instruction. 3D printing has seen growing applications in medicine, owing to its advantages in recreating anatomical detail using readily available medical images.
Methods: Anonymised computer tomography data of a patient’s thorax was processed using modelling software to create a printable model. Compared to a previous study, 3D printing was applied extensively to this task trainer. A mixture of fused deposition modelling and material jetting technology allowed us to introduce superior haptics while keeping costs low. Given material limitations, the chest wall thickness was reduced to preserve the ease of incision and dissection.
Results: The complete thoracostomy task trainer costs approximately SGD$130 (or USD$97), which is significantly cheaper compared to the average commercial task trainer. It requires approximately 118 hours of print time. The complete task trainer simulates the consistencies of ribs, intercostal muscles and skin.
Conclusion: By utilising multiple 3D printing technologies, this paper aims to outline an improved methodology to produce a 3D printed chest tube simulator. An accurate evaluation can only be carried out after we improve on the anatomical fidelity of this prototype. A 3D printed task trainer has great potential to provide sustainable simulation-based education in the future.
Assessment of medical professionalism using the Professionalism Mini-Evaluation Exercise (P-MEX): A survey of faculty perception of relevance, feasibility and comprehensiveness
Authors: Fong Warren , Kwan Yu Heng , Yoon Sungwon , Phang Jie Kie , Thumboo Julian , Ng Swee Cheng
Published: November 2020

Introduction: This study aimed to examine the perception of faculty on the relevance, feasibility and comprehensiveness of the Professionalism Mini Evaluation Exercise (P-MEX) in the assessment of medical professionalism in residency programmes in an Asian postgraduate training centre.
Methods: Cross-sectional survey data was collected from faculty in 33 residency programmes. Items were deemed to be relevant to assessment of medical professionalism when at least 80% of the faculty gave a rating of ≥8 on a 0-10 numerical rating scale (0 representing not relevant, 10 representing very relevant). Feedback regarding the feasibility and comprehensiveness of the P-MEX assessment was also collected from the faculty through open-ended questions.
Results: In total, 555 faculty from 33 residency programmes participated in the survey. Of the 21 items in the P-MEX, 17 items were deemed to be relevant. For the remaining four items ‘maintained appropriate appearance’, ‘extended his/herself to meet patient needs’, ‘solicited feedback’, and ‘advocated on behalf of a patient’, the percentage of faculty who gave a rating of ≥8 was 78%, 75%, 74%, and 69% respectively. Of the 333 respondents to the open-ended question on feasibility, 34% (n=113) felt that there were too many questions in the P-MEX. Faculty also reported that assessments about ‘collegiality’ and ‘communication with empathy’ were missing in the current P-MEX.
Conclusion: The P-MEX is relevant and feasible for assessment of medical professionalism. There may be a need for greater emphasis on the assessment of collegiality and empathetic communication in the P-MEX.
Full Field EOR Implementation of A Low Cost Surfactant Continuous Injection at Arahan-Banjarsari, South Sumatra
Authors: Ariadji T.
Published: November 2020

The objective of this paper is to describe a series of laboratory work results in conjunction with successful implementation of the surfactant (micellar) continuous injection in the Muara Enim sand of the Arahan-Banjarsari Field, South Sumatra. A series of lab tests were conducted using field cores and fluids taken from the Arahan-Banjarsari (AR-BS) field. The tests included phase behavior, mixture viscosity measurement, spontaneous imbibition, and static isotherm adsorption tests. Several surfactant formulas had been tested to find the most consistent and most suitable to the reservoir conditions. The surfactant injection was started in March 2009 into three AR wells. The injection was divided into 4 stages with initial concentration of 0.45% and the final concentration of 0.1%. Total volume of micellar solution injected in 110 days was 52,365 bbls. An increase in oil production was observed not only in two AR wells but also in 8 wells in the neighboring BS field (500 meters distance) after 140 days since injection of micellar solution started with injection rates of 200-250 bpd. Two BS wells were reopened and produced 28% and 54% water cut (the water cut before the two wells were shut in was 19% and 76%). This micellar solution injection managed to decrease the decline rate of 70% to 26% per year, increase production rate from AR and BS fields from 90 bopd to a peak of 220 bopd in 5 months since injection started, and reserves enhancement of 183 M bbls (10% OOIP) during 3.5 years of continuous injection. The low cost, full scale chemical EOR leads to changes in the common understanding about micellar flooding and shows a high impact on oil recovery of 183 Mbls (AB-5c sand with OOIP of 1.8 MMSTB).
IMPROVING STUDENTS’ SPEAKING PERFORMANCE THROUGH VLOG
Authors: Mandasari Berlinda , Aminatun Dyah
Published: November 2020

The shifting of English language learning from conventional way to technology-based learning is popular nowadays. It is necessary to identify the effect of using technology towards the students’ performance. One of technology that currently well-known is Vlog. This study aims at identifying the improvement of the students’ performance after learning English using Vlog. The participants of this study is 40 students majoring English Education Department of Universitas Teknokrat Indonesia. They enrolled in Transactional Conversation subject where practicing English through vlog was carried out. The design of this research is quantitative study in which the researcher employed pre-test and post-test. The result of pre-test and post-test was analyzed by using statistics descriptive and statistics inferential (Mann-Whitney U). The result of analysis is there is significant improvement towards students’ performance after learning English by using Vlog.
Peningkatan Kedisiplinan dengan Konseling Kelompok Melalui Teknik Token Economy Bagi Peserta Didik SMPN 3 Banyuates
Authors: Nurhayati Titie
Published: November 2020

Tujuan dalam penelitian tinakan bimbingan dan konseling ini adalah untuk meningkatkan perilaku disiplin pada peserta didik. Ada banyak treatment yang dapat dilakukan untuk meningkatkan kedisiplinan, salah satunya adalah terapi modifikasi perilaku. Dalam penelitian ini menggunakan teknik token economy, yaitu dengan memberikan penguatan positif (positive reinforcement). Penelitian tindakan bimbingan dan konseling ini menggunakan jenis penelitian tindakan kelas. Teknik purposive sampling digunakan pada penelitian tindakan bimbingan dan konseling ini. Berdasarkan hasil observasi yang dilakukan selama penelitian, terjadi perubahan perilaku disiplin secara signifikan dari tindakan pemberian token economy pada siklus 1 dan siklus 2
Upaya Meningkatkan Asertivitas Melalui Layanan Konseling Kelompok Dengan Teknik Asertif Training Pada Siswa Asuh Kelas X DPIB 2 SMK Negeri 1 Sampang
Authors: Hidayatullah Syaiful
Published: November 2020

Perilaku asertif menjadi hal penting yang dimiliki individu. Perilaku asertif mencerminkan bagaimana individu mampu untuk mengenali diri sendiri dan jujur dalam berhubungan atau berinteraksi dengan orang lain. Perilaku asertif mengarahkan individu untuk mampu menghargai ekspresi dari perasaan positif dan negative diri sendiri maupun orang lain dan mampu untuk melakukan control diri tanpa rasa bersalah. Tujuan Penelitian ini bertujuan untuk mengkaji Upaya peningkatkan Asertivitas Melalui Layanan Konseling Kelompok Dengan Teknik Asertif Training Pada Siswa. Dalam Penelitian ini subjek penelitian adalah siswa yang memiliki tingkat asertivitas rendah di kelas X DPIB 2 SMK Negeri 1 Sampang. Penelitian ini berlangsung dalam dua siklus. Teknik pengumpulan data menggunakan angket assetivitas siswa. Metode analisis data yang digunakan menganalisis tingkat keberhasilan atau persentase pemberian reinforcement terhadap Asertivitas siswa dilakukan dengan cara memberikan evaluasi angket. Dari hasil siklus I dan II terdapat peningkatan kriteria asertivitas dari “rendah” ke “sedang” dan “tinggi”. Konseling kelompok dengan teknik assertive training dapat meningkatkan assertivitas siswa.
Evaluasi Pemilihan Penyedia Jasa Truk Angkutan Barang Menggunakan Metode Simple Additive Weighting
Authors: Somadi Somadi , Pasaribu Desi Arista , Khoiriyah Rizky
Published: November 2020

This study aims to determine the priority of freight truck service providers at PT. XYZ by using the simple additive weighting method. Data collection techniques using interviews and documentation study. The criteria for selecting a freight trucking service provider uses the dimensions of the service marketing mix. Based on the results of the study that the freight truck service providers selected to be the first choice priority of the three existing service providers are Chess Prime Trans, followed by MGM Bosco Logistics as the second choice, and PT. Indo Partner Logistics as a third choice.
Perbandingan Terapi Topikal Natrium Klorida 0,9% dengan Minyak Biji Jintan Hitam (Nigella sativa) terhadap Waktu Transpor Mukosilliar Hidung Penderita Rinitis Alergi
Authors: Diyanah Fatimah Qonitah , Haitamy M Nurrizki , Kusumawati Anis , Kadarullah Oke
Published: November 2020

Rinitis alergi terjadi 40% pada populasi dunia, di Indonesia cenderung meningkat setiap tahunnya. Paparan allergen yang menstimulus gejala rinitis dapat menganggu proses bersihan hidung dan  meningkatkan waktu Transpor Mukosilliar  (TMS). Semprot hidung NaCl 0,9% merupakan salah satu terapi suportif rinitis alergi. Minyak Biji Jintan Hitam diketahui sebagai antihistamin dan antiinflamasi yang dapat memperbaiki gejala rinitis alergi danTMS hidung. Mengetahui perbandingan terapitopikal NaCl 0,9% dengan Minyak Biji Jintan Hitam terhadap waktu TMS hidung penderita rinitis alergi. Penelitian ini merupakan clinical trial dengan melibatkan 10 subyek penelitian. Subyek dipilih dengan menggunakan kuesioner SFAR. Subyek yang terpilih dibagi menjadi 2 kelompok yang diterapi dengan topikal NaCl 0,9% dan Minyak Biji Jintan Hitam selama 14 hari. Sebelum dan sesudah terapi dilakukan pemeriksaan waktu TMS dengan tessakarin. Data perbedaan waktu TMS hidung sebelum dan sesudah terapi dianalisis dengan Paired T-Test. Data perbandingan waktu TMS hidung antara kelompok NaCl 0,9% dan Minyak Biji Jintan Hitam dianalisis dengan Independent T-Test. Waktu TMS hidung sebelum dan sesudah terapi pada kelompok NaCl 0,9% dan Minyak Biji Jintan Hitam masing - masing memiliki p>0,05. Perbandingan penurunan waktu TMS pada kedua terapi menunjukkan perbedaan yang tidak bermakna (p=0,831). Terdapat perbedaan yang tidak bermakna pada waktu TMS hidung terapi topikal NaCl 0,9% dan minyak biji jintan hitam pada penderita rinitis alergi.
Comparison of the Effect of Ethanol Extracts of Phaleria macrocarpa (scheff.Boerl) Fruit and Metformin on the Kidney Function of Hyperglycaemic Rat Models
Authors: Sutrisna Eman , Sutrisna Eman , Gumilas Nur Signa Aini , Topa Mus , Sulistyoningrum Evy
Published: November 2020

Diabetes mellitus is a disease that often causes diabetic nephropathy complications due to persistent hyperglycaemia. Phaleria macrocarpa (scheff. Boerl)  is one of the plants that has been widely used in the treatment of diabetes mellitus, but its effect on the risk of diabetic nephropathy is still unknown. A dose of 300mg / 200gbb / day is known as an effective dose that can significantly reduce blood sugar levels in diabetic rat. The Streptozotocin Effect (STZ) causes damage to the pancreas and causes hyperglycaemia. This study aims to compare the effect of Phaleria macrocarpa (scheff. Boerl) fruit extracts on urea and creatinine levels as a parameter of kidney function in hyperglycaemic mouse models. The study was carried out experimentally using the post-test only with control group design. Fifteen white rats were divided into 3 groups. All rats were induced with 40 mg / 200gbb of Streptozotocin (STZ) to experience hyperglycaemia. Group I as negative control was given aquades. Group II was given ethanol extract of Phaleria macrocarpa (scheff. Boerl) with a dose of 300 mg / 200gbw / day. Group III was given Metformin at a dose of 150 mg / 200gbw / day. On the 22nd day of treatment, blood specimens were taken for examination of urea and creatinine levels. The research data were statistically analyzed with α <0.05; CI95%. The mean of urea levels in Group I (79.80 ± 25.09 mg / dl), II (76.00 ± 22.59 mg / dl and III (59.60 ± 6.35 mg / dl). Kruskal-Wallis test results showed no significant difference in urea levels between treatment groups (p value = 0.273; CI95%). The mean of creatinine levels in Group I (0.68 ± 0.07 mg / dl), II (0.63 ± 0.14 md / dL) and III (0.98 ± 0.25 mg / dL). One Way Anova and Post hoc test results showed a significant difference in mean creatinine levels between Groups I and III (p = 0.014; 95% CI) and II with III ( p value = 0.006; CI95%). the results of this study can be concluded that the extract of Phaleria macrocarpa (scheff. Boerl) fruit flesh at a dose of 300 mg / 200gbb has better effectiveness than metformin dose 150 mg / 200gbb in repairing the kidney function of hyperglycaemia rats.
PENGETAHUAN DAN SIKAP TERHADAP SWAMEDIKASI OBAT HERBAL PADA MAHASISWA KEDOKTERAN SELAMA PAN-DEMI COVID19
Authors: Septianawati Paramita , Pratama Tisna Sendy , Pratiwi Hadis , Sumoprawiro Mambodyanto
Published: November 2020

Latar Belakang : Coronavirus disease (COVID 19) sudah terjadi hampir di seluruh dunia, termasuk Indonesia. FK UMP memiliki misi keunggulan dalam bidang Herbal. Tujuan Penelitian ini untuk mengetahui pengetahuan dan sikap pola penggunaan obat herbal pada mahasiswa FK UMP selama menghadapi COVID 19. Jenis penelitian adalah penelitian cross sectional yang dilakukan pada April 2020. Dalam penelitian ini menggunakan kuisioner sebagai media untuk memperoleh data. Jumlah sampel penelitian ini berjumlah 41 responden. Analisis deskriptif dilaporkan untuk menggambarkan demografi, frekuensi pengetahuan dan sikap mahasiswa FK UMP terhadap swamedikasi obat/ramuan herbal selama Pandemi COVID 19. Sebanyak 46,4% mahasiswa meminum obat herbal selama pandemic COVID 19. Adapun ramuan herbal yang dikonsumsi adalah jahe (15%), bawang putih (24,4%), Echinacea sp. (7,3%), kunyit (5,1%), kemangi (10,3%), kurma merah (7,7%), jeruk (43,6%) dan jambu (17,9%). Dengan demikian, penelitian ini menemukan bahwa pengetahuan mahasiswa mengenai obat herbal dan pengetahuan tentang COVID 19 adalah baik. Sikap tentang penggunaan obat herbal dan sikap selama menghadapi pandemi COVID 19 pada mahasiswa FK UMP termasuk kategori baik. Kesimpulan dari penelitian ini menunjukkan bahwa swamedikasi obat herbal selama pandemic COVID 19 di kalangan mahasiswa FK UMP rendah, dikarenakan obat herbal yang dikonsumsi selama pandemic COVID 19 hanya untuk peningkatan imunitas tubuh.
Studi Epidemiologi Perkembangan Prehipertensi Menjadi Normotensi, Tetap Prehipertensi, Hipertensi Stage I dan Stage II Setelah 10 Tahun
Authors: Alatas HAIDAR
Published: November 2020

AbstractIndividual with a systolic BP of 120 to 139 mmHg or diastolic BP of 80 to 89 mmHg should be considered as prehypertensive and require health-promoting lifestyle modifications to prevent CVD. After four years, 40% of prehypertension that is not managed properly becomes serious hypertension. Approximately 31–37% of US adults are prehypertensive, is associated with 3-fold greater likelihood of developing hypertension and roughly twice the cardiovascular events. What is the progress of prehypertension after 10 years in rural populations? Will it be normal (normotensive), still prehypertension, become stage I hypertension or stage II hypertension. Epidemiological studies were conducted in Mlati Village, Sleman, Yogyakarta. From the prehypertension subject data as many as 4,091 who were on the computer, after 10 years were selected who were still aged 30-59 years, were willing to take further research and then do interviews and blood pressure checks. The data obtained was analyzed. Of the 743 subjects now aged 30-59 years, who had prehypertension ten years ago, their blood pressure became normal as many as 183 (25%), still prehypertension was 328 (44%), became stage I hypertension as much as 152 (20%) and became hypertensive stage II as many as 80 (11%).  AbstrakPrehipertensi menurut JNC 7 adalah tekanan darah 120-139/80-89 mmHg. Dalam 4 tahun, 40% prehipertensi dilaporkan akan menjadi hipertensi  yang serius bila tidak dikelola dengan baik. Sekitar 31-37% populasi di Amerika Serikat dewasa merupakan  penyandang prehipertensi dan berhubungan dengan kecenderungan tiga kali lipat untuk mengalami hipertensi dan dua kali lipat untuk  mengalami kejadian kardiovaskular dibanding orang dengan tekanan darah normal. Bagaimana perkembangan prehipertensi setelah 10 tahun pada populasi daerah pedesaan? Apakah akan menjadi normal (normotensi), tetap prehipertensi, menjadi hipertensi stage I atau hipertensi stage II. Dilakukan studi epidemiologi di Desa Mlati, Sleman, Yogyakarta. Dari data subyek prehipertensi sebanyak 4.091 yang ada di komputer, setelah 10 tahun dipilih yang masih berusia 30-59 tahun, bersedia mengikuti penelitian lanjutan kemudian dilakukan wawancara dan pemeriksaan tekanan darah. Data yang didapatkan dianalisis. Dari 743 subyek sekarang berusia 30-59 tahun, yang sepuluh tahun lalu prehipertensi, didapatkan tekanan darahnya menjadi normal sebanyak 183 (25%), tetap prehipertensi sebanyak 328 (44%), menjadi hipertensi stage I sebanyak 152 (20%) dan menjadi hipertensi stage II sebanyak 80 (11%).
Diogo de Macedo e o Museu de Arte Contemporânea: Pioneirismo e herança na redefinição do Museu de Arte
Authors: Falcão Isabel
Published: November 2020

Diogo de Macedo (1889-1959) assume a direção do Museu Nacional de Arte Contemporânea (MNAC) em 1 de julho de 1944, sendo, nos 33 anos de existência do museu, o primeiro escultor a ocupar este cargo. A sua atividade desenvolve-se entre 1944 e 1959, articulando e contextualizando a intervenção no museu com as suas convicções culturais e estéticas, evidenciadas numa intensa atividade como crítico e historiador da arte.

Com este estudo pretende-se interpretar o projeto delineado pelo escultor Diogo de Macedo para o MNAC, analisando o seu pioneirismo, destacando os aspetos mais inovadores, e registando, simultaneamente, as fragilidades e fracassos da sua ação. Uma ação centrada na valorização do espaço expositivo, no estudo e divulgação das coleções e na constituição de um acervo representativo da arte contemporânea.

Esta função é compreendida em necessária articulação, e contextualização, com o percurso biográfico de Macedo, com a sua obra escultórica e com a sua atividade de crítico, ensaísta e historiador.

Pretende-se, ainda, demonstrar que Diogo de Macedo cria um programa museológico para o museu, com um projeto específico que relaciona investigação científica sobre a coleção e divulgação da arte, com o desígnio da construção de uma identidade institucional e científica para o MNAC, no panorama da cultura portuguesa da primeira metade do século XX.
Museus e Escolas: as relações pedagógicas e o papel dos jovens
Authors: Ornelas Marta
Published: November 2020

Este livro apresenta uma investigação que versa sobre diversos modos de relação entre jovens do 3.º ciclo da escolaridade obrigatória e museus de arte contemporânea. Através de quatro estudos de casos, foi possível verificar que os jovens reclamam por práticas mais participativas do que aquelas que tradicionalmente a escola e os museus lhes oferecem. O cumprimento do currículo e as imposições programáticas dos museus constituem constrangimentos à criação de relações pedagógicas entre museus e escolas.

Além disso, a legitimidade para ensinar está ainda muito centrada na figura docente ou de quem dinamiza as visitas nos museus, enquanto aos estudantes é atribuído um papel essencialmente subordinado.

É a escola que aprende com o museu, sendo muito raramente criadas oportunidades para que o museu aprenda também com a escola. Contudo, a forma como as professoras e as educadoras de museu encaram o conhecimento, a aprendizagem e a arte contemporânea é determinante para o modo como os estudantes aprendem. Se aos jovens for dado um espaço participativo e de autoria na relação com o museu, isso permitirá a criação de propostas alternativas às macronarrativas, sejam estas provenientes dos museus ou mesmo da própria escola tradicional que perpetua a ordem social.

No caso da investigação que aqui se expõe, foram as propostas alternativas concebidas pelos jovens que lhes proporcionaram a realização de aprendizagens dotadas de sentido.
Future changes in growing degree days of wheat crop in Pakistan as simulated in CORDEX South Asia experiments
Authors: Shaheen Nuzba , Jahandad Ambreen , Goheer Muhammad Arif , Ahmad Qurat-ul Ain
Published: November 2020

Climate change has become a global phenomenon having severe ramifications on socio-economic sectors such as agriculture, water resources, environment and health. The effects of changing climate are much more prominent on developing economies as compared to the implications on well-developed industrial powers. Pakistan is one of the struggling agricultural economies confronting the issues of food insecurity as a consequence of profound climatic conditions. Notable changes in climatic factors such as temperature can have a direct effect on Growing Degree Days (GDD) and may alter the growing season length (GSL). Growing season length is an important factor in ensuring that each crop developmental stage has a sufficient period for the transition to the next developmental stage. Lengthening or shortening of GSL can have dire threats to crop development and ultimately, production. This study has been conducted to assess the changes in GSL in response to the variability in daily maximum and minimum temperatures with a base temperature of 5°C across Northern, Central and Southern Pakistan. RCP 4.5 and 8.5 have shown an increase of 2°C and 5.4°C in minimum and maximum temperatures, respectively.