Effect of antioxidant dental gel on the adaptation of the oral mucosa to removable dentures.
Authors: Samoilova M. , Kosyreva T. , Voeikova O. , Dragunova S. , Sakanyan M. , Katbeh I. , Ezhova E. , Tuturov N. , Davidian O. , Samusenkov V. , Grishaeva K. 
Published: July 2024

Determination of the effect of a gel with natural astaxanthin on the timing of adaptation of the oral mucosa to removable dentures. The gel made from a natural antioxidant reduces the risk of stomatitis, values of hygienic indices and traumatic factor. Aims: Reduction of the period of adaptation to removable dentures in patients with partial adentia. The objective was to evaluate the effect of antioxidant gel on the oral mucosa. Patients and Methods. The state of oropharyngeal microbiocenosis was studied in 105 patients aged 30-65 years old who were divided into three groups: the main group - 45 patients; comparison group - 35 patients; control group - 25 patients. The groups were comparable by age; gender differences were not taken into account. Patients in the main group received astaxanthin gel for 7 days after the delivery of the removable denture. Patients in the comparison group did not receive astaxanthin gel after the delivery of the removable denture. Clinical indices were used to assess oral hygiene: oral hygiene index plaque index API, gingivitis index, papillary-marginal-alveolar - (PMA); gingival sulcus bleeding index – SBI. We used a therapeutic and prophylactic agent in the form of a gel containing natural astaxanthin - 0.026%, vitamin E - 2.2%, Coenzyme Q - 1.5%. Result. According to the results of the analysis of the visual control and the results of photometric registration of the speed of healing and adaptation of the patient to the prosthesis, the data obtained differed in the patients of the 1st and 2nd groups. Visual control data of the dynamics of inflammatory changes in the oral mucosa development, received by the results of semi-quantitative evaluation of the severity of edema and hyperemia indicate significant differences in the rate of their reduction depending on the type of the applied tactics. In the case of group 1, prophylactic gel was applied from the time of denture fitting, and in group 2, only denture correction was performed. Thus, the index of hyperemia intensity testified to the dis-appearance of signs of the latter in Group 1 (gel with natural astaxanthin) - by the 4th day of observation, in Group 2 - by the 10th day after prosthesis correction. Complete disappearance of the signs of edema, respectively, was ascertained: in Group 1 - on the 4-5th day of observation and in Group 2 - by the 10th-11th day, at that, edema was retained 1-2 days longer. The method of photoplanimetric registration of the healing rate objectively confirmed the results obtained. Conclusion. Studies of the effectiveness of the gel containing natural astaxanthin indicate improved oral hygiene parameters of patients and reduced concentration of bacterial endotoxin and plasmalogen metabolites of oral microorganisms after 7 days of using the gel. Prophylactic dental gel with astaxanthin reduces the rate of adaptation to removable dentures by 1.7 - 2 times and reduces the risk of denture stomatitis due to wound healing, anti-inflammatory and anti-microbial action.