bluuebunny/crossref_metadata_2025 huggingface dataset:
The relationship between agility, linear sprinting, and vertical jumping performance in U-14 and professional senior team sports players
Authors: Gisladottir Thordis , Petrović Miloš , Sinković Filip , Novak Dario
Published: April 2024

Aim

The aim of this paper is to determine the relationship between the modified agility T-test (change of direction speed ability), 20-meter sprint test (linear speed ability), and countermovement jump test (vertical jumping performance) in U-14 and professional senior team sports players.

Methods

The sample included 78 (59 female and 19 male) U-14 athletes (age 11.70 ± 1.33 years, height 153.00 ± 12.20 cm and body mass 47.10 ± 11.20 kg) and 43 (18 female and 25 male) senior professional athletes (age 24.80 ± 6.58 years, height 169.00 ± 9.13 cm and body mass 71.20 ± 15.10 kg). Both samples participated in different team sports including basketball, field hockey, and football. Participants underwent a series of tests to assess their speed, change of direction speed, and explosive power. Speed assessments involved 20-meter sprints (sec), while change of direction speed was measured using the modified agility T-test (sec). Explosive power was evaluated through countermovement jumps (CMJ), where concentric mean force (N), concentric peak force (N), concentric peak velocity (m/s), eccentric peak force (N), jump height (cm), peak power (W), peak power/BM (W/kg), RSI (m/s) and vertical velocity (m/s) were determined. Pearsońs product moment-correlation coefficient (r) served to determine correlations and linear regression was conducted to explain the relationship between the dependent variable (CODS) and independent variables (S20 m and CMJ). The level of statistical significance was set at p < 0.05 and the confidence interval was 95%.

Results

The Pearson product-moment correlation analysis in the U-14 athletes indicated no correlation (r = 0.11, p = 0.34) between the 20-meter linear sprint speed and the modified change of direction T-test. Additionally, the results revealed that 4 out of 10 CMJ values showed a significant moderate correlation (r = 0.3, p < 0.05) between CMJ and the modified change of direction T-test. In contrast, senior players exhibited statistically significant correlations in all variables. A significant correlation (r = 0.90, p = 0.01) was found between 20-meter linear sprint speed and the modified change of direction T-test, while CMJ values showed a range of correlations from moderate to large. In both competitive categories, according to the linear regression model, only linear sprint speed over 20-meters significantly explained (p < 0.05) the CODS speed ability, while the other CMJ parameters did not reach the significance level (p > 0.05).

Conclusion

The study emphasized the influence of explosive power performance (CMJ) and linear speed (S20 m) on agility (CODS) within the sample, particularly among professional senior team sports players. These findings indicate that agility, linear sprinting, and jumping abilities may share common underlying factors.
Lost gallstones during laparoscopic cholecystectomy as a common but underestimated complication—case report and review of the literature
Authors: Danhel L. , Fritz A. , Havranek L. , Kratzer T. , Punkenhofer P. , Punzengruber A. , Rezaie D. , Tatalovic S. , Wurm M. , Függer R. , Biebl M. , Kirchweger P.
Published: April 2024

Introduction

Laparoscopic cholecystectomy (LC) represents one of the most commonly performed routine abdominal surgeries. Nevertheless, besides bile duct injury, problems caused by lost gallstones represent a heavily underestimated and underreported possible late complication after LC.

Methods

Case report of a Clavien-Dindo IVb complication after supposedly straightforward LC and review of all published case reports on complications from lost gallstones from 2000-2022.

Case Report

An 86-year-old patient developed a perihepatic abscess due to lost gallstones 6 months after LC. The patient had to undergo open surgery to successfully drain the abscess. Reactive pleural effusion needed additional drainage. Postoperative ICU stay was 13 days. The patient was finally discharged after 33 days on a geriatric remobilization ward and died 12 months later due to acute cardiac decompensation.

Conclusion

Intraabdominal abscess formation due to spilled gallstones may present years after LC as a late complication. Surgical management in order to completely evacuate the abscess and remove all spilled gallstones may be required, which could be associated with high morbidity and mortality, especially in elderly patients. Regarding the overt underreporting of gallstone spillage in case of postoperative gallstone-related complications, focus need be put on precise reporting of even apparently innocuous complications during LC.
Storage Conditions of Refrigerated Prickly Pears in Small Processing Industries
Authors: Díaz-Delgado Goretti L. , Rodríguez-Rodríguez Elena M. , Cano M. Pilar , Lobo M. Gloria
Published: April 2024

Prickly pears (Opuntia ficus-indica), which are well known for their beneficial properties for human health, are the subject of many studies due to their high content of bioactive compounds. However, the presence of spines on the fruit’s surface is a factor that limits consumption. Therefore, the viability and nutritional quality of peeled and packaged white, orange, and pink prickly pears were studied during storage. Refrigerated whole fruits stored at 8 °C and 85% RH for 0, 1, 2, 3, or 4 weeks were electrically peeled and packaged with micro-perforated film. At each time point, their microbial quality; physical parameters, such as hardness, texture, and color; and chemical parameters, including pH, titratable acidity, total soluble solids content, sugar content, ascorbic acid content, antioxidant capacity, and total phenol content, were analyzed. The mesophilic aerobic counts were lower than the values established by Spanish legislation (7 log (CFU/g f.w.)) until day 8 after packaging (or until day 6 after 4 weeks of storage). The hardness, texture, pH, sugar content, ascorbic acid content, and antioxidant capacity decreased significantly between day 0 and day 8 after packaging, independently of the number of weeks for which the whole fruits had been refrigerated previously. Furthermore, the changes in the parameters analyzed for whole fruits during storage were less remarkable. The evaluation of the sensory features was positive throughout the preserved period. The minimally processed prickly pears retained suitable microbial, nutritional, and sensory qualities when the whole fruits had been refrigerated for 1, 2, 3, or 4 weeks, facilitating their management in small processing companies.
Differences in the Synovial Fluid Proteome of Septic and Aseptic Implant Failure
Authors: Sowislok Andrea , Busch André , Kaschani Farnusch , Kaiser Markus , Jäger Marcus
Published: April 2024

Implant loosening is a severe complication after total joint replacement. Here, differential diagnosis between septic and aseptic cases is crucial for further surgical treatment, but low-grade periprosthetic joint infections (PJIs) in particular remain a challenge. In this study, we analyzed the synovial fluid proteome of 21 patients undergoing revision surgery for septic (eight cases) or aseptic (thirteen cases) implant failure using LC-MS/MS to identify potential new biomarkers as future diagnostic tools. Staphylococci were found in four cases, Streptococci in two cases, Serratia marcescens and Cutibacterium acnes in one case. Proteomic analysis of the synovial fluid resulted in the identification of 515 different proteins based on at least two peptides. A statistical comparison revealed 37 differentially abundant proteins (p < 0.05), of which 17 proteins (46%) showed a higher abundance in the septic group. The proteins with the highest fold change included the known marker proteins c-reactive protein (7.57-fold) and the calprotectin components protein S100-A8 (4.41-fold) and protein S100-A9 (3.1-fold). However, the protein with the highest fold change was leucine-rich alpha-2-glycoprotein 1 (LRG1) (9.07-fold), a currently discussed new biomarker for inflammatory diseases. Elevated LRG1 levels could facilitate the diagnosis of PJI in the future, but their significance needs to be further investigated.
Intelligent Analysis System for Teaching and Learning Cognitive Engagement Based on Computer Vision in an Immersive Virtual Reality Environment
Authors: Li Ce , Wang Li , Li Quanzhi , Wang Dongxuan
Published: April 2024

The 20th National Congress of the Communist Party of China and the 14th Five Year Plan for Education Informatization focus on digital technology and intelligent learning and implement innovation-driven education environment reform. An immersive virtual reality (IVR) environment has both immersive and interactive characteristics, which are an important way of virtual learning and are also one of the important ways in which to promote the development of smart education. Based on the above background, this article proposes an intelligent analysis system for Teaching and Learning Cognitive engagement in an IVR environment based on computer vision. By automatically analyzing the cognitive investment of students in the IVR environment, it is possible to better understand their learning status, provide personalized guidance to improve learning quality, and thereby promote the development of smart education. This system uses Vue (developed by Evan You, located in Wuxi, China) and ECharts (Developed by Baidu, located in Beijing, China) for visual display, and the algorithm uses the Pytorch framework (Developed by Facebook, located in Silicon Valley, CA, USA), YOLOv5 (Developed by Ultralytics, located in Washington, DC, USA), and the CRNN model (Convolutional Recurrent Neural Network) to monitor and analyze the visual attention and behavioral actions of students. Through this system, a more accurate analysis of learners’ cognitive states and personalized teaching support can be provided for the education field, providing certain technical support for the development of smart education.
Research on the Correlation of Safety Risk of Railway Bridge Construction Based on Meta-Analysis
Authors: Shan Zhi , Liang Yuling , Yu Zhiwu , Chen Huihua
Published: April 2024

China has emerged as a prominent global player in the field of railways, with numerous railway construction projects spanning across diverse locations. Railway bridges, as a crucial component of railway construction, warrant significant attention. Meta-analysis, a statistical method that systematically synthesizes research findings, has been utilized to summarize and compare the results of safety risk management studies pertaining to railway bridge construction in China. By integrating social network analysis and evidence-based assessment of the literature, this study explores the interrelationships among risk factors. Within a specific railway bridge construction project, various safety risk factors may originate from common sources, including environmental factors, material and equipment factors, technical factors, management factors, personnel factors, and bridge-specific factors. Notably, there exists coupling among these security risk factors, whereby the presence or occurrence of one factor can influence the probability or severity of consequences associated with other factors. The results reveal that safety risk factors in railway bridge construction accumulate and propagate, thereby impacting the efficacy of safety risk management. Moreover, these factors are significantly influenced by the complexities inherent in the geo-meteorological and social-technical systems. This finding provides valuable insights for innovations in security risk management practices and offers suggestions for future innovation pathways.
Studying the Role of Visuospatial Attention in the Multi-Attribute Task Battery II
Authors: Gugerell Daniel , Gollan Benedikt , Stolte Moritz , Ansorge Ulrich
Published: April 2024

Task batteries mimicking user tasks are of high heuristic value. Supposedly, they measure individual human aptitude regarding the task in question. However, less is often known about the underlying mechanisms or functions that account for task performance in such complex batteries. This is also true of the Multi-Attribute Task Battery (MATB-II). The MATB-II is a computer display task. It aims to measure human control operations on a flight console. Using the MATB-II and a visual-search task measure of spatial attention, we tested if capture of spatial attention in a bottom-up or top-down way predicted performance in the MATB-II. This is important to understand for questions such as how to implement warning signals on visual displays in human–computer interaction and for what to practice during training of operating with such displays. To measure visuospatial attention, we used both classical task-performance measures (i.e., reaction times and accuracy) as well as novel unobtrusive real-time pupillometry. The latter was done as pupil size covaries with task demands. A large number of analyses showed that: (1) Top-down attention measured before and after the MATB-II was positively correlated. (2) Test-retest reliability was also given for bottom-up attention, but to a smaller degree. As expected, the two spatial attention measures were also negatively correlated with one another. However, (3) neither of the visuospatial attention measures was significantly correlated with overall MATB-II performance, nor with (4) any of the MATB-II subtask performance measures. The latter was true even if the subtask required visuospatial attention (as in the system monitoring task of the MATB-II). (5) Neither did pupillometry predict MATB-II performance, nor performance in any of the MATB-II’s subtasks. Yet, (6) pupil size discriminated between different stages of subtask performance in system monitoring. This finding indicated that temporal segregation of pupil size measures is necessary for their correct interpretation, and that caution is advised regarding average pupil-size measures of task demands across tasks and time points within tasks. Finally, we observed surprising effects of workload (or cognitive load) manipulation on MATB-II performance itself, namely, better performance under high- rather than low-workload conditions. The latter findings imply that the MATB-II itself poses a number of questions about its underlying rationale, besides allowing occasional usage in more applied research.
Developing Higher-Order Unconditionally Positive Finite Difference Methods for the Advection Diffusion Reaction Equations
Authors: Ndou Ndivhuwo , Dlamini Phumlani , Jacobs Byron Alexander
Published: April 2024

This study introduces the higher-order unconditionally positive finite difference (HUPFD) methods to solve the linear, nonlinear, and system of advection–diffusion–reaction (ADR) equations. The stability and consistency of the developed methods are analyzed, which are necessary and sufficient for the numerical approach to converge to the exact solution. The problem under consideration is of the Cauchy type, and hence, Von Neumann stability analysis is used to analyze the stability of the proposed schemes. The HUPFD’s efficacy and efficiency are investigated by calculating the error, convergence rate, and computing time. For validation purposes, the higher-order unconditionally positive finite difference solutions are compared to analytical calculations. The numerical results demonstrate that the proposed methods produce accurate solutions to solve the advection diffusion reaction equations. The results also show that increasing the order of the unconditionally positive finite difference leads an implicit scheme that is conditionally stable and has a higher order of accuracy with respect to time and space.
Comparative Study on the Effectiveness of Three Inoculation Methods for Valsa sordida in Populus alba var. pyramidalis
Authors: Shen Wanna , Pan Long , Fu Yuchen , Suo Yutian , Zhang Yinan , Liu Huixiang , Su Xiaohua , Zhao Jiaping
Published: April 2024

A key step in the study of tree pathology is the identification of an appropriate method for inoculating pathogens of diseases in branches and trunks. Pathogens of diseases in branches and trunks are commonly inoculated through punching, burning, and toothpick inoculation. However, there is a lack of comparative analyses of the inoculation outcomes of these three methods. In this work, six-year-old P. alba var. pyramidalis were inoculated with V. sordida using punching, burning, and toothpick techniques to investigate the differences in the effectiveness of these inoculation methods. Results reveal that the incidence rate was 93.55% in the toothpick inoculation group, significantly higher than the 80.65% in the burning inoculation group (chi-square, n = 90, p = 0.007), while punching inoculation exhibited significant pathological responses in the early stages, with spontaneous healing in the later stage. Additionally, toothpick inoculation was more efficient in inducing Valsa canker when inoculating the pathogen at the bottom of the tree, with lower intra- and inter-row spacing (stand density) providing better outcomes than higher intra- and inter-row spacing. The results of this study demonstrate that toothpick inoculation is an optimal option for studying the artificial inoculation of V. sordida in six-year-old P. alba var. pyramidalis, providing technical support for research on poplar diseases and offering a theoretical basis for the inoculation of other diseases in the branch and trunk.
Selection of Leptin Surrogates by a General Phenotypic Screening Method for Receptor Agonists
Authors: Wang Tao , Chen Xixi , Yang Guang , Shi Xiaojie
Published: April 2024

There is a high demand for agonist biomolecules such as cytokine surrogates in both biological and medicinal research fields. These are typically sourced through natural ligand engineering or affinity-based screening, followed by individual functional validation. However, efficient screening methods for identifying rare hits within immense libraries are very limited. In this research article, we introduce a phenotypic screening method utilizing biological receptor activation-dependent cell survival (BRADS). This method offers a high-throughput, low-background, and cost-effective approach that can be implemented in virtually any biochemical laboratory setting. As a proof-of-concept, we successfully identified a surrogate for human leptin following a two-week cell culture process, without the need for specialized high-throughput equipment or reagents. This surrogate effectively emulates the activity of native human leptin in cell validation assays. Our findings not only underscore the effectiveness of BRADS but also suggest its potential applicability to a broad range of biological receptors, including Notch and GPCRs.
Safety and Effectiveness of Meatal Mobilization (MEMO) Technique for Glandular, Coronal, and Subcoronal Hypospadias Repair in Children: A 5-Year Single-Center Study with 105 Hypospadias
Authors: Pogorelić Zenon , Milovac Boris , Čohadžić Tin , Todorić Jakov
Published: April 2024

Background: This study aims to compare outcomes of treatment, in terms of early and late complications, between the Snodgrass and meatal mobilization (MEMO) techniques in children operated on because of distal hypospadias. Methods: The medical records of 127 children who underwent glandular, coronal, or subcoronal hypospadias repair between 1 January 2019 and 31 December 2023 were retrospectively reviewed. A total of 105 children met the inclusion criteria and were included in further analysis. The inclusion criteria were pediatric patients who underwent glandular, coronal, or subcoronal hypospadias repair using MEMO (n = 49) or the Snodgrass technique (n = 56) as a comparative group. The primary outcome of this study was the incidence of early and late complications with two different surgical techniques. Secondary outcomes were the duration of surgery, the length of hospital stay, the number of readmissions or unplanned returns to the operating room, and repeat surgeries between groups. Results: The median age of all patients was 17 (interquartile range, IQR 13, 29) months, with a median follow-up of 26 (IQR 17, 34) months. Regarding the type of hypospadias, the majority of patients in both groups were categorized as coronal and subroronal hypospadias. Regarding the incidence of postoperative complications, a significantly lower incidence of postoperative complications was found in the MEMO group compared to the Snodgrass group (n = 4; 8.2% vs. n = 14; 25%; p = 0.037). An urethrocutaneous fistula was the most common complication in the Snodgrass group (n = 8; 14.3%), while in the MEMO group, only one patient (2%) developed a fistula (p = 0.034). The incidence of meatal stenosis (p = 0.621) and wound infections (p > 0.999) was low in both groups. No further complications were recorded during the follow-up period. Duration of surgery (41 min (IQR 38, 47) vs. 51 min (IQR 45.5, 61); p < 0.001), duration of hospitalization (1 day (IQR 1, 2) vs. 3 days (IQR 2, 6); p < 0.001), and time to catheter removal (3 days (IQR 2.5, 5) vs. 6 days (IQR 6, 8); p < 0.001) were significantly lower in patients operated on with MEMO compared to the Snodgrass technique. Only one case of readmission due to severe wound infection which led to suturing line dehiscence was recorded in the Snodgrass group. The incidence of redo surgery was significantly lower in the MEMO group than in the Snodgrass group (n = 3; 6.1% vs. n = 11; 19.6%; p = 0.048). Conclusions: MEMO is a safe and effective technique that can be used for the treatment of distal hypospadias. It showed excellent outcomes, cosmetic results, and a low incidence of complications as well as a significantly shorter duration of surgery compared to the Snodgrass technique.
Storytelling of Myocarditis
Authors: Thiene Gaetano
Published: April 2024

In 1900, Fiedler first reported autopsy cases with peculiar inflammation of the myocardium, which he named interstitial myocarditis. He postulated an isolated cardiac inflammation of the myocardium in the absence of multiorgan involvement and with a poor prognosis due to invisible microorganisms, which years later would have been identified as viruses. The revision of original histologic sections by Schmorl showed cases with lymphocytes and others with giant-cell inflammatory histotypes. The in vivo diagnosis of myocarditis became possible thanks to right cardiac catheterization with endomyocardial biopsy (EMB). The gold standard for diagnosis was achieved with the employment of immunohistochemistry and molecular investigation by Polymerase Chain Reaction (PCR), which allows for the detection of viruses as causal agents. Both RNA and DNA were revealed to be cardiotropic, with a common receptor (CAR). A protease, coded by coxsackie virus, disrupts the cytoskeleton and accounts for cell death. Unfortunately, vaccination, despite having been revealed to be effective in animal experiments, has not yet entered the clinical field for prevention. Cardiac Magnetic Resonance turned out to be a revolutionary tool for in vivo diagnosis through the detection of edema (inflammatory exudate). Myocarditis may be fulminant in terms of clinical presentation but not necessarily fatal. The application of ExtraCorporeal Membrane Oxygenation (ECMO) allows for relieving the overloaded native heart.
Precision of Measurements of Delayed Slip in Structural High-Strength Assemblies by Contact and Optical Methods
Authors: Ortega José Joaquín , Pan Kaiming , Ruiz Gonzalo , Zhang Xiaoxin
Published: April 2024

Structural bolted connections of steel plates must fulfill the requirements specified by the standard EN 1090-2:2018 in the European Union. For the slip-resistant joints, the standard establishes the experimental procedure to obtain the delayed slip under a constant loading, which should not exceed 2 μm from the first five minutes to three hours. However, the usual extensometers available in laboratories, like LVDTs, lack the necessary precision to obtain a reliable measurement of such a small displacement because, even if their resolution is 1 μm, the scatter of repeated measurements of the same distance is normally higher. In contrast, the resolution and precision in optical methods like Digital Image Correlation (DIC) can be easily set under 1 μm depending on the number of pixels covering the studied area and the performed subpixel interpolation. This work introduces the use of DIC for delayed slip tests. In comparison with an LVDT, it is verified that this technique is a valid alternative to measure displacements at that scale with a simpler experimental setup.
Unlocking Weather Observations at the End of the World: Late-XIX and Early-XX Century Monthly Mean Temperature Climatology for Southern Patagonia
Authors: Canziani Pablo O. , Lakkis S. Gabriela , Yuchechen Adrián E. , Bonfilli Oscar
Published: April 2024

A climate analysis of the monthly mean temperatures of Southern Patagonia during the late-XIXth and early-XXth centuries was carried out as part of the international data rescue Atmospheric Circulation Reconstructions over the Earth (ACRE) program partnership in Argentina, together with other data sources with regional and global records. The data from these diverse sources were combined to carry out a study in the coastal region of Patagonia, including Tierra del Fuego, between 42° S and 55° S for 11 locations. Furthermore, HadSST monthly/seasonal fields during the period 1880–1920 were also used. Both mean monthly and seasonal temperature values and timeseries variability were considered. Their analysis shows consistent behavior within the study region and compared to Southern Hemisphere mean results, which are characterized by a warm late-XIX century and a cooler early-XX century. This is also in agreement with SST variability along the coasts of Patagonia and hemispheric records. A comparison with present-day observations, where available, also yields consistent behavior. Low-frequency variability, i.e., in periods longer than 3 years, during the study period is consistent with present variability. Trend estimates at Trelew and Rio Gallegos for the period 1901–2020 yield significant trends, consistent with hemispheric warming at their latitudes.
Unlocking Weather Observations at Puerto Madryn-Patagonia, Argentina, 1902–1915
Authors: Lakkis Susan Gabriela , Canziani Pablo O. , Yuchechen Adrián E.
Published: April 2024

The recovery of early records of maximum, minimum, and mean temperatures; pressure; and relative humidity measurements in Puerto Madryn for the period 1902–1915 is presented. A careful evaluation of the quality of the data was performed using internal coherence, tolerance, and temporal consistency tests. The monthly mean series of all the variables, constructed from daily raw data, were subject to several homogeneity tests, and only discontinuities in pressure and relative humidity were found. The homogenized monthly mean series were compared with the Twentieth Century Reanalysis series in annual and seasonal time steps. In addition, the trends of each variable were assessed using the Mann–Kendall procedure, and correlations between relative humidity and the other variables were examined. The results show a remarkably good agreement between the temperature measurements and reanalysis values with a Spearman correlation coefficient of 0.94. The raw data for minimum and maximum temperatures represent a very good upper and lower bound for the mean temperature values of both observational and reanalysis data. Agreement was found to be lower for relative humidity and pressure with the correlation coefficients being close to 0.6 in both cases. No trends were found for the variables. The correlation analysis of the humidity measurements with the other variables shows an inverse dependence of the temperatures and no relatedness with the pressure values.
“Every Cloud Has a Silver Lining”: How Three Rare Diseases Defend Themselves from COVID-19 and What We Have Learnt from It
Authors: Cacciapuoti Martina , Caputo Ilaria , Stefanelli Lucia Federica , Davis Paul A. , Nalesso Federico , Calò Lorenzo A.
Published: April 2024

The process of SARS-CoV-2 infection, responsible for the COVID-19 pandemic, is carried out through different steps, with the interaction between ACE2 and Spike protein (S) being crucial. Besides of that, the acidic environment of endosomes seems to play a relevant role in the virus uptake into cells and its intracellular replication. Patients affected by two rare genetic tubulopathies, Gitelman’s and Bartter’s Syndromes, and a rare genetic metabolic disease, Fabry Disease, have shown intrinsic protection from SARS-CoV-2 infection and COVID-19 on account of specific intrinsic features that interfere with the virus uptake into cells and its intracellular replication, which will be reported and discussed in this paper, providing interesting insights for present and future research.
Evolution of Diagnoses, Survival, and Costs of Oncological Medical Treatment for Non-Small-Cell Lung Cancer over 20 Years in Osona, Catalonia
Authors: Parera Roig Marta , Colomé David Compte , Colomer Gemma Basagaña , Sardo Emilia Gabriela , Tournour Mauricio Alejandro , Fernández Silvia Griñó , Ominetti Arturo Ivan , Juvanteny Emma Puigoriol , Polo José Luis Molinero , Jobal Daniel Badia , Espejo-Herrera Nadia
Published: April 2024

Non-small-cell lung cancer (NSCLC) has experienced several diagnostic and therapeutic changes over the past two decades. However, there are few studies conducted with real-world data regarding the evolution of the cost of these new drugs and the corresponding changes in the survival of these patients. We collected data on patients diagnosed with NSCLC from the tumor registry of the University Hospital of Vic from 2002 to 2021. We analyzed the epidemiological and pathological characteristics of these patients, the diverse oncological treatments administered, and the survival outcomes extending at least 18 months post-diagnosis. We also collected data on pharmacological costs, aligning them with the treatments received by each patient to determine the cost associated with individualized treatments. Our study included 905 patients diagnosed with NSCLC. We observed a dynamic shift in histopathological subtypes from squamous carcinoma in the initial years to adenocarcinoma. Regarding the treatment approach, the use of chemotherapy declined over time, replaced by immunotherapy, while molecular therapy showed relative stability. An increase in survival at 18 months after diagnosis was observed in patients with advanced stages over the most recent years of this study, along with the advent of immunotherapy. Mean treatment costs per patient ranged from EUR 1413.16 to EUR 22,029.87 and reached a peak of EUR 48,283.80 in 2017 after the advent of immunotherapy. This retrospective study, based on real-world data, documents the evolution of pathological characteristics, survival rates, and medical treatment costs for NSCLC over the last two decades. After the introduction of immunotherapy, patients in advanced stages showed an improvement in survival at 18 months, coupled with an increase in treatment costs.
Prehabilitation in Adults Undergoing Cancer Surgery: A Comprehensive Review on Rationale, Methodology, and Measures of Effectiveness
Authors: Guerra-Londono Carlos E. , Cata Juan P. , Nowak Katherine , Gottumukkala Vijaya
Published: April 2024

Cancer surgery places a significant burden on a patients’ functional status and quality of life. In addition, cancer surgery is fraught with postoperative complications, themselves influenced by a patient’s functional status. Prehabilitation is a unimodal or multimodal strategy that aims to increase a patient’s functional capacity to reduce postoperative complications and improve postoperative recovery and quality of life. In most cases, it involves exercise, nutrition, and anxiety-reducing interventions. The impact of prehabilitation has been explored in several types of cancer surgery, most commonly colorectal and thoracic. Overall, the existing evidence suggests prehabilitation improves physiological outcomes (e.g., lean body mass, maximal oxygen consumption) as well as clinical outcomes (e.g., postoperative complications, quality of life). Notably, the benefit of prehabilitation is additional to that of enhanced recovery after surgery (ERAS) programs. While safe, prehabilitation programs require multidisciplinary coordination preoperatively. Despite the existence of numerous systematic reviews and meta-analyses, the certainty of evidence demonstrating the efficacy and safety of prehabilitation is low to moderate, principally due to significant methodological heterogeneity and small sample sizes. There is a need for more large-scale multicenter randomized controlled trials to draw strong clinical recommendations.
Large-Scale Re-Implantation Efforts for Posidonia oceanica Restoration in the Ligurian Sea: Progress and Challenges
Authors: Robello Chiara , Acunto Stefano , Leone Laura Marianna , Mancini Ilaria , Oprandi Alice , Montefalcone Monica
Published: April 2024

The Ligurian Sea (NW Mediterranean) has been a focal point for numerous interventions aimed at restoring Posidonia oceanica meadows. The success of pioneer restoration actions in France during the 1970s stimulated similar initiatives across the Mediterranean Sea. Early attempts in the Ligurian Sea were implemented in 1993 and 1996 on limited seabed areas (i.e., tens of square meters) at the two coastal sites of Sori and Rapallo (Liguria, NW Italy). No further initiatives have been reported for the Ligurian Sea until 2022. In that year, a large-scale restoration project, which uses biodegradable mats coupled with metal mesh, began in Liguria. Different levels of anthropogenic pressure and wave exposure characterize the three investigated locations: (1) Portofino, on the eastern Liguria and on the border with the Portofino Marine Protected Area; (2) Bergeggi in the central Liguria and within the Isola di Bergeggi Marine Protected Area; and (3) Sanremo in the western Liguria, without any formal protection. Despite recent setbacks caused by severe storms in late 2023, which particularly damaged the Portofino site, ongoing monitoring revealed promising survival rates. Most notably, the site in Bergeggi displayed a 90% survival rate in September 2023. Although challenges to restore P. oceanica beds persist, such as mitigating damages caused by unpredictable events, this extensive re-implantation initiative offers the opportunity to evaluate the effectiveness of new basin-scale restoration strategies. This approach marks an important step in the conservation of Posidonia oceanica habitat.
An Advanced Explainable Belief Rule-Based Framework to Predict the Energy Consumption of Buildings
Authors: Kabir Sami , Hossain Mohammad Shahadat , Andersson Karl
Published: April 2024

The prediction of building energy consumption is beneficial to utility companies, users, and facility managers to reduce energy waste. However, due to various drawbacks of prediction algorithms, such as, non-transparent output, ad hoc explanation by post hoc tools, low accuracy, and the inability to deal with data uncertainties, such prediction has limited applicability in this domain. As a result, domain knowledge-based explainability with high accuracy is critical for making energy predictions trustworthy. Motivated by this, we propose an advanced explainable Belief Rule-Based Expert System (eBRBES) with domain knowledge-based explanations for the accurate prediction of energy consumption. We optimize BRBES’s parameters and structure to improve prediction accuracy while dealing with data uncertainties using its inference engine. To predict energy consumption, we take into account floor area, daylight, indoor occupancy, and building heating method. We also describe how a counterfactual output on energy consumption could have been achieved. Furthermore, we propose a novel Belief Rule-Based adaptive Balance Determination (BRBaBD) algorithm for determining the optimal balance between explainability and accuracy. To validate the proposed eBRBES framework, a case study based on Skellefteå, Sweden, is used. BRBaBD results show that our proposed eBRBES framework outperforms state-of-the-art machine learning algorithms in terms of optimal balance between explainability and accuracy by 85.08%.
A Combined Computational Fluid Dynamics and Thermal–Hydraulic Modeling Approach for Improving the Thermal Performance of Corrugated Tank Transformers: A Comparative Study
Authors: Wang Chunping , Sun Qingjun , Al-Abadi Ali , Wu Wei
Published: April 2024

In this study, we present a complete analysis of the thermal behavior of an oil-filled distribution transformer using two different approaches: numerically, by applying computational fluid dynamics (CFD) simulations; and analytically, by using thermal–hydraulic modelling (THM). The THM method becomes challenging when the corrugated transformer tank wall structures are complex, and therefore CFD simulations are required to provide in-depth details of the winding oil thermal–hydraulic behavior and to generate parameters for improving the THM calculation. The numerical and analytical thermal performance results were then compared with heat-run measurements of a case study transformer and the accuracy of both approaches on different thermal performance parameters was validated. This study has certain reference value for improving the thermal performance and operation efficiency of distribution transformers, and eventually aims to provide engineers with an effective tool to design the most efficient and reliable distribution transformers with corrugated tank walls for various applications.
Impact of Active Galactic Nuclei Feedback on the Dynamics of Gas: A Review across Diverse Environments
Authors: Raouf Mojtaba , Purabbas Mohammad Hossein , Fazel Hesar Fatemeh
Published: April 2024

This review examines the relationship between black hole activity and kinematic gas–star misalignment in brightest group galaxies (BGGs) with different merger rates. The formation history of galaxy groups is assessed through “age-dating” as an indicator of distinct major mergers involving the BGGs. BGGs within groups characterized by a higher frequency of major mergers are more likely to host active SMBHs. A consistent correlation is identified between the level of black hole activity, as indicated by the 1.4 GHz and 325 MHz radio emissions, and the degree of kinematic misalignment between the gas and stellar components in BGGs. In dynamically fossil groups, where black hole accretion rate is relatively (∼1 dex) lower due to the lack of recent (≤1 Gyr) major mergers, there is reduced (∼30%) misalignment between the gas and stellar components of BGGs compared to non-fossil groups. Additionally, this study reveals that BGGs in non-fossil groups show higher levels of star formation rate and increased occurrence of mergers, contributing to observed color differences. Exploring the properties and dynamics of the gas disk influenced by mechanical AGN feedback through hydrodynamic simulations suggests that AGN wind-induced effects further lead to the persistent gas misalignment in the disk around the supermassive black hole.
Temperature Dependence of the Dielectric Constant on the Lunar Surface Based on Mini-RF and Diviner Observations
Authors: Sun Chenhao , Miyamoto Hideaki , Kobayashi Makito
Published: April 2024

Radar observation is an effective way to understand subsurface structures in terms of the dielectric constant, whose controlling factors include chemical composition, packing density, and water/ice content. Recently, laboratory measurements have shown that the dielectric constant of lunar regolith simulants also depends on the temperature, which has never been evaluated from remote sensing data. In this study, we estimated the dielectric constant from the Miniature Radio Frequency (Mini-RF) data on a lunar crater floor in the north polar region at two different local times (i.e., different surface temperatures). We calculated the dielectric constant using the inversion method and obtained the bolometric surface temperature from the Diviner Lunar Radiometer Experiment (Diviner) data. The histograms of the estimated dielectric constant values are different between the two local times. This could be interpreted as a result of the temperature dependence of the dielectric constant, while further evaluation of the influence of topography on the incidence angle and small surface roughness is needed. Nevertheless, our result suggests that the temperature dependence of the dielectric constant should be considered when interpreting S-band radar observations of the Moon and other celestial bodies with large surface temperature differences.
Radon Emanation and Dynamic Processes in Highly Dispersive Media
Authors: Zaalishvili Vladislav B. , Melkov Dmitry A. , Martyushev Nikita V. , Klyuev Roman V. , Kukartsev Vladislav V. , Konyukhov Vladimir Yu. , Kononenko Roman V. , Gendon Angelika L. , Oparina Tatiana A.
Published: April 2024

The paper considers a dispersive geological medium (seismically turbid medium, as defined by A.V. Nikolaev), which is in a stress–strain state. Results of studies on the joint monitoring of seismic effects and radon emanation in various geological environments are presented. It is concluded that the turbidity of the medium, as a statistical characteristic, can be generalized in terms of other media parameters, such as permeability. A stable connection between radon emanation and dynamic processes occurring in a geological environment and caused by external influences has been established. The concentration of radon can also reflect the degree of enrichment of the environment by underground fractures. Consequently, saturation of the environment with radon provides information about the presence of disturbances in a geological environment in the form of cracks and a stress–strain state of the medium before and after seismic loadings. Radon observations make it possible to assess a continuity of the environment and the possibility of leaching in natural conditions. Therefore, it could be efficiently used for underground leaching efficiency assessment.
Shear Banding and Cracking in Unsaturated Porous Media through a Nonlocal THM Meshfree Paradigm
Authors: Pashazad Hossein , Song Xiaoyu
Published: April 2024

The mechanical behavior of unsaturated porous media under non-isothermal conditions plays a vital role in geo-hazards and geo-energy engineering (e.g., landslides triggered by fire and geothermal energy harvest and foundations). Temperature increase can trigger localized failure and cracking in unsaturated porous media. This article investigates the shear banding and cracking in unsaturated porous media under non-isothermal conditions through a thermo–hydro–mechanical (THM) periporomechanics (PPM) paradigm. PPM is a nonlocal formulation of classical poromechanics using integral equations, which is robust in simulating continuous and discontinuous deformation in porous media. As a new contribution, we formulate a nonlocal THM constitutive model for unsaturated porous media in the PPM paradigm in this study. The THM meshfree paradigm is implemented through an explicit Lagrangian meshfree algorithm. The return mapping algorithm is used to implement the nonlocal THM constitutive model numerically. Numerical examples are presented to assess the capability of the proposed THM mesh-free paradigm for modeling shear banding and cracking in unsaturated porous media under non-isothermal conditions. The numerical results are examined to study the effect of temperature variations on the formation of shear banding and cracking in unsaturated porous media.
The Role of Autologous Stem Cell Transplantation in the Treatment of Newly Diagnosed Multiple Myeloma: Is It Time to Rethink the Paradigm in the Era of Targeted Therapy?
Authors: Richardson Paul G.
Published: April 2024

High-dose melphalan (HDM) plus autologous stem cell transplant (ASCT) remains a standard-of-care treatment approach for eligible patients with newly diagnosed multiple myeloma (NDMM) based on demonstrated superiority in terms of progression-free survival (PFS) versus nontransplant approaches. Very high rates of minimal residual disease (MRD)-negative responses are also being seen with novel triplet and quadruplet induction regimens plus HDM-ASCT. However, recent clinical trials have shown no overall survival benefit with transplant versus nontransplant approaches. Furthermore, HDM is associated with several important downsides, including acute and long-term toxicities, transient decreases in quality of life, the need for hospitalization, an increased mutational burden at relapse, and an elevated risk of second primary malignancies. In this context, given the highly heterogeneous nature of MM in the NDMM patient population, as well as the continued emergence of novel agents and treatment approaches, there is an increasing rationale for considering deferred HDM-ASCT approaches in selected patients. Approaches under investigation include MRD-adapted therapy and the use of novel immune-based therapies as alternatives to HDM-ASCT. Ongoing developments in understanding the pathobiology and prognostic factors in NDMM, plus immune profiling and routine MRD evaluation, will result in novel, HDM-sparing treatment paradigms, enabling further improvement in patient outcomes.
The Impact of Cancer Stem Cells in Colorectal Cancer
Authors: Radu Petru , Zurzu Mihai , Tigora Anca , Paic Vlad , Bratucu Mircea , Garofil Dragos , Surlin Valeriu , Munteanu Alexandru Claudiu , Coman Ionut Simion , Popa Florian , Strambu Victor , Ramboiu Sandu
Published: April 2024

Despite incessant research, colorectal cancer (CRC) is still one of the most common causes of fatality in both men and women worldwide. Over time, advancements in medical treatments have notably enhanced the survival rates of patients with colorectal cancer. Managing metastatic CRC involves a complex tradeoff between the potential benefits and adverse effects of treatment, considering factors like disease progression, treatment toxicity, drug resistance, and the overall impact on the patient’s quality of life. An increasing body of evidence highlights the significance of the cancer stem cell (CSC) concept, proposing that CSCs occupy a central role in triggering cancer. CSCs have been a focal point of extensive research in a variety of cancer types, including CRC. Colorectal cancer stem cells (CCSCs) play a crucial role in tumor initiation, metastasis, and therapy resistance, making them potential treatment targets. Various methods exist for isolating CCSCs, and understanding the mechanisms of drug resistance associated with them is crucial. This paper offers an overview of the current body of research pertaining to the comprehension of CSCs in colorectal cancer.
Integrated Omics Analysis Uncovers the Culprit behind Exacerbated Atopic Dermatitis in a Diet-Induced Obesity Model
Authors: Ahn You Mee , Jung Jeeyoun , Lee So Min
Published: April 2024

Atopic dermatitis (AD), a chronic inflammatory skin disease, is exacerbated by obesity, yet the precise linking mechanism remains elusive. This study aimed to elucidate how obesity amplifies AD symptoms. We studied skin samples from three mouse groups: sham control, AD, and high-fat (HF) + AD. The HF + AD mice exhibited more severe AD symptoms than the AD or sham control mice. Skin lipidome analysis revealed noteworthy changes in arachidonic acid (AA) metabolism, including increased expression of pla2g4, a key enzyme in AA generation. Genes for phospholipid transport (Scarb1) and acyltransferase utilizing AA as the acyl donor (Agpat3) were upregulated in HF + AD skin. Associations were observed between AA-containing phospholipids and skin lipids containing AA and its metabolites. Furthermore, imbalanced phospholipid metabolism was identified in the HF + AD mice, marked by excessive activation of the AA and phosphatidic acid (PA)-mediated pathway. This imbalance featured increased expression of Plcb1, Plcg1, and Dgk involved in PA generation, along with a decrease in genes converting PA into diglycerol (DG) and CDP-DG (Lpin1 and cds1). This investigation revealed imbalanced phospholipid metabolism in the skin of HF + AD mice, contributing to the heightened inflammatory response observed in HF + AD, shedding light on potential mechanisms linking obesity to the exacerbation of AD symptoms.