bluuebunny/crossref_metadata_2025 huggingface dataset:
Melanoma in Iranian Childhood and Adolescence: An Analysis of 14 Patients
Authors: Rakhshan Azadeh , Moradi Afshin , Masoudi Elham
Published: March 2023

Background: Skin cancer is the most common cancer in Iran. Given the importance of early diagnosis in treating early tumors, knowledge of the demographic and pathological findings of the disease is helpful. Objectives: The aim of present study was to investigate the incidence, trend and risk factors of melanoma in Iranian childhood and adolescents. Methods: The present retrospective study was performed between 2005 and 2014 on registered data in the National Cancer Registry System, Iran. The age group studied was patients 18 years or younger. Data included demographic status, risk factors, clinical and histopathological characteristics. Results: The results showed that 8 (57.1%) of 14 patients were males. The mean age of the study population was 8.71 ± 6.02 years (range, 1 - 15 years). Ten (71.4%) patients were of Fars ethnic groups. In terms of tumor invasiveness, 13 (92.9%) patients were invasive and one (7.1%) patient was in situ. The growth phase of melanoma was vertical in 13 (92.9%) patients and radial phase in one (7.1%) patient. In terms of lymph node metastasis, it was observed in only one patient. Surgical treatment was performed on all patients. Melanoma histology was nodular in 3 patients and unspecified or unregistered in the rest. The most area of the tumor was in the head/neck and lower limbs. Conclusions: According to the results, regardless of the differences in the specific coverage of the Iranian people, the distribution and statistical characteristics of malignant melanoma in Iran are almost similar to other countries in the world. Further studies are recommended to confirm the findings of the present study.
Experiences from the first implementation round of two electronics courses utilizing flipped learning method
Authors: Laine Katja , Sipilä Erja
Published: March 2023

During the past years we have witnessed various development trends in learning. More and more the learning has moved online thus making it independent of time and place, students’ responsibility of their own learning has increased, methods that promote active learning have gained more interest as they result in better learning results, and the role of a teacher has shifted towards a facilitator of learning. Consequently, the flipped learning pedagogical approach has become more common in recent years as it is one way to answer these trends. This concept paper introduces two studies of practice in which flipped learning approach was implemented for the first time in a bachelor level university course of electronics at Tampere University (TU) during the academic year 2021 – 2022. The structure of the flipped courses consisted of online pre-class study materials and assignments, face-to-face learning events, various individual and group learning assignments and so-called prime time small group meetings with the teacher. Flexibility and versability of the learning experiences, both-way feedback possibilities as well as a combination of individual and collaborative face-to-face and online learning were emphasized in the course design. According to the feedback many students felt that this flipped learning approach promoted learning and encouraged to study evenly throughout the entire course. Furthermore, the teachers' thoughts after the first implementation round are considered e.g., which parts and practices were successes, and which need further development. In addition, thoughts about teachers' workload and institute's support in utilizing flipped learning method are shared.
Factors of acceptance of digital tools: the example of the 3DEXPERIENCE platform in the context of collaborative projects
Authors: Lanthony Antoine , Konan Rodrigue , Filogene Fedler
Published: March 2023

In face of the omnipresence of digital technology in all aspects of life, education and training players are encouraged to adapt to digital tools. This should enable learners to grasp and take advantage of the potential it offers, while developing the various dimensions of digital skills. However, the introduction of digital tools in education and training environments still raises many challenges, especially because any new technology requires from all actors, teachers and learners in particular, a change in their habits and postures. This action research takes as a theoretical analysis framework the model of instrumental acceptance applied to information and communication technologies developed by Caron and Heutte (2017). It focuses on the factors of acceptance and use of a digital tool in general, in particular the 3DExperience platform, by learners involved in applied collaborative projects. It is based on several experiments carried out with students from ISAE-Supméca, a French engineering school, and other students from partner institutions as part of the EXAPP_3D educational research project. With a methodology that focuses on interpretative phenomenological analysis (Restivo et.al., 2018), it provides scientific support for the sometimes complex challenges of integrating new tools in engineering schools.
Broadening personal competence profiles through transdisciplinary project modules
Authors: Marckwardt Anja , Kühne Stefan , Behme Jonas , Bleszynski Charlotte , Bullerdieck Philip , Dang Tra Mi , Ghazi Mohamed , Oberschmidt Dirk
Published: March 2023

Engineering education today is often organised in discipline-specific modules. Although it is essential to build up basic knowledge, cross-disciplinary knowledge is fundamental for solving complex problems. Transdisciplinary approaches can provide the necessary hard and soft skills, improve self-determination in education and broaden personal competence profiles. The experience gained is conveyed using the example of project-based modules on the topics of a) AI applications to minimise racial biasing in medical technology and b) construction of microfluidic systems to avoid animal testing. These were developed over several semesters by interdisciplinary student groups involving industry and research partners. The concept was initially carried out online in an interdisciplinary project module focusing on individual learning objectives, composed of the disciplines "Mechanical Engineering", "Computational Engineering Science", "Physical Engineering Sciences" as well as "Biomedical Engineering" and is being expanded in a hybrid-transdisciplinary manner through gradual additions including systems engineering, philosophy and sustainability in technology, ergonomics and human-machine systems. Through active participation in researching and solving real challenges, collaboration of transdisciplinary teams over several group generations and setting individual learning goals, profound knowledge and new methodological competences can be acquired beyond engineering disciplines. The integration of non-technical methods and approaches allows students to recognise complex problems and identify the necessary competences in order to realise a successful project. To further expand this approach, a new module concept for interdisciplinary cooperation in production engineering was developed. It takes up the aspects of individual, project-based learning and brings together all the competences of the institute in transdisciplinary exchange.
Reconciling the Epistemic and the Zetetic
Authors: Haziza Eliran ,   Philosophy Documentation Center
Published: March 2023

In recent work, Jane Friedman has argued that commonly accepted epistemic norms conflict with a basic instrumental principle of inquiry, according to which one ought to take the necessary means to resolving one’s inquiry. According to Friedman, we ought to reject the epistemic norms in question and accept instead that the only genuine epistemic norms are zetetic norms—norms that govern inquiry. I argue that there is a more attractive way out of the conflict, one which reconciles the epistemic and the zetetic.
Управление транспортными работами компанией ТОО «Damu Logistics» на основе современного информационного обеспечения
Authors: КЕНЖЕБАЕВА Г.Ж. , БАЙБУСИНОВА М.А. , САРКЫТОВ Н.К.
Published: March 2023

Мақалада кәсіпорынның көлік және қойма жұмыстарын оңтайландыру мақсатында заманауи ақпараттандыру қызметтері қолданылады. Қазіргі уақытта логистика елдегі ең дамып келе жатқан салалардың бірі болып табылады. Жеткізу тізбегінің орындалу уақытын қысқарту логистикалық процестің тиімділігін арттырудың бір бөлігі болып табылады. Толыққанды орындау үшін заманауи ақпараттандыру қызметін пайдалану қажет. Кәсіпорынның өнімділігін одан әрі арттыру маңызды мәселе болып табылады. Аралас экономика және Қазақстанда тауарларды өткізу саласында бәсекелестік ортаны қалыптастыру көлік процесіне қатысушылар арасындағы ұйымдастырушылық және экономикалық қатынастарда елеулі өзгерістерді қалыптастыруға ықпал етті.

В статье используются современные услуги информатизации с целью оптимизации выполнения предприятием транспортных и складских работ. В настоящее время логистика является одной из самых развивающихся отраслей в стране. Сокращение времени выполнения цепочки поставок является частью повышения эффективности логистического процесса. Для полноценного выполнения необходимо использовать современную службу информатизации. Дальнейшее повышение производительности предприятия является важнейшим вопросом. Формирование конкурентной среды в сфере смешанной экономики и сбыта товаров в Казахстане способствовало формированию существенных изменений в организационных и экономических отношениях между участниками транспортного процесса.

The article uses modern informatization services in order to optimize the performance of transport and warehouse work by the enterprise. Currently, logistics is one of the most developing industries in the country. Reducing the lead time of the supply chain is part of improving the efficiency of the logistics process. For full-fledged implementation, it is necessary to use a modern informatization service. Further improvement of the company's productivity is the most important issue. The formation of a competitive environment in the field of mixed economy and the sale of goods in Kazakhstan contributed to the formation of significant changes in organizational and economic relations between participants in the transport process.
Жүк вагоны элементтерінің сенімділігін ықтималдық талдаудың негізгі міндеттері
Authors: СЕРГЕЕВ К.А. , САДЫКОВА О.И. , ЛЕВЧУК Т.В. , ТУРСЫМБЕКОВА З.Ж.
Published: March 2023

В данной статье обоснована практическая значимость вероятностных методов исследования надежности элементов грузовых вагонов на всех этапах проектирования и эксплуатации. Выявлены конкретные задачи, которые необходимо решить для целенаправленного вероятностного исследования надежности элементов грузового вагона. При написании статьи авторы использовали теоретические методы: изучение исследований в данной области, анализ технической информации и документации.

Бұл мақалада жобалау мен пайдаланудың барлық кезеңдерінде жүк вагондары элементтерінің сенімділігін зерттеудің ықтималды әдістерінің практикалық маңыздылығы негізделген. Жүк вагоны элементтерінің сенімділігін мақсатты ықтималды зерттеу үшін шешілуі қажет нақты міндеттер анықталды. Мақала жазу кезінде авторлар теориялық әдістерді қолданды: осы саладағы сұрыптауларды зерттеу, техникалық ақпарат пен кұжаттаманы талдау.

This article substantiates the practical significance of probabilistic methods for studying the reliability of freight car components at all stages of design and operation. Specific tasks have been identified that need to be solved for a targeted probabilistic study of the reliability of freight car elements. When writing the article, the authors used theoretical methods: the study of research in this field, the analysis of technical information and documentation.
Елдер мен өңірлердің әлеуметтік-экономикалық қауіпсіздігі мәселелері: теориялық-әдіснамалық аспектілері
Authors: ГУСЕВА В.И. , ГУСЕВА Ю.В.
Published: March 2023

В настоящей статье представлены результаты теоретико-методологических аспектов исследования социально-экономической безопасности стран и регионов. В условиях пандемии COVID-19 в мире произошло углубление неравенства доходов между и богатыми и бедными, что негативно отразилось на развитии мировой экономики, как в целом, так и в отдельных странах и регионах. Эксперты Международного Валютного фонда исследовали влияние COVID-19 на уровень неравенства доходов населения в разных странах и сделали неутешительный вывод, что пандемия короновируса сильнее повлияла на разрыв в доходах населения разных стран мира, нежели предыдущие глобальные эпидемии.

Бұл мақалада елдер мен аймақтардың әлеуметтік-экономикалық қауіпсіздігін зерттеудің теориялық және әдіснамалық аспектілерінің нәтижелері келтірілген. COVID-19 пандемиясы жағдайында әлемде байлар мен кедейлер арасындағы табыс теңсіздігінің тереңдеуі байқалды, бұл жалпы, сондай-ақ жекелеген елдер мен өңірлердегі әлемдік экономиканың дамуына кері әсерін тигізді. Халықаралық валюта қорының сарапшылары COVID-19-ның әртүрлі елдердегі халық табысының теңсіздігі деңгейіне әсерін зерттеп, короновирус пандемиясы алдыңғы жаһандық эпидеттерге қарағанда әлемнің әртүрлі елдеріндегі халық табысының алшақтығына көбірек әсер етті деген көңіл көншітпейтін қорытынды жасады.

This article presents the results of theoretical and methodological aspects of the study of socio-economic security of countries and regions. In the context of the COVID-19 pandemic, there was a deepening of income inequality between rich and poor in the world, which negatively affected the development of the global economy, both in general and in individual countries and regions. Experts of the International Monetary Fund investigated the impact of COVID-19 on the level of income inequality in different countries and made a disappointing conclusion that the coronavirus pandemic had a stronger impact on the income gap of the population of different countries of the world than previous global epidemics.
Ұйымның қазіргі менеджмент жүйесіндегі өзгерістерді басқару мәселелері
Authors: БАЯХМЕТОВА А.Т. , САРЖАНОВ Т.С.
Published: March 2023

В современной системе менеджмента организации одним из важных звеньев по праву можно считать управление изменениями. Отсутствие понимания природы организационного развития и управление изменениями не позволяют организации пойти по пути своего процветания, укрепить свои позиции на рынке и быть конкурентоспособным. Каждая организация на пути своего жизненного цикла сталкивается с проблемами, решение которых приводит либо к дальнейшему росту, либо к закрытию организации. Данный вопрос включен в перечень изучаемых тем в силу его важности. Предложенный материал знакомит с возможными трудностями, с которыми организация сталкивается на своем жизненном пути, раскрывает причины их возникновения и предлагает пути их разрешения

Ұйымның қазіргі менеджмент жүйесінде өзгерістерді басқару заңдағы маңызды буындардың бірі деп санауға болады. Ұйымдастырушылық дамудың табиғаты туралы түсініктің болмауы және өзгерістерді басқару ұйымның өркендеу жолымен жүруіне, нарықтағы позициясын нығайтуға және бәсекеге қабілетті болуына жол бермейді. Әрбір ұйым өзінің өмірлік циклі жолында проблемаларға тап болады, олардың шешімі ұйымның одан әрі өсуіне немесе жабылуына әкеледі. Бұл мәселе оның маңыздылығына байланысты зерттелетін тақырыптар тізіміне енгізілген. Ұсынылған материал ұйымның өмір жолында кездесетін мүмкін қиындықтармен таныстырады, олардың пайда болу себептерін ашады және оларды шешу жолдарын ұсынады

In the modern management system of an organization, change management can rightfully be considered one of the important links. The lack of understanding of the nature of organizational development and change management do not allow the organization to follow the path of its prosperity, strengthen its position in the market and be competitive. Every organization on the path of its life cycle faces problems, the solution of which leads either to further growth or to the closure of the organization. This issue is included in the list of topics being studied due to its importance. The proposed material introduces the possible difficulties that an organization faces on its life path, reveals the causes of their occurrence and suggests ways to resolve them
Бақылауды басқарудың экономикалық негіздері
Authors: ЕРАЛИЕВА Я.А. , СОТНИК М.С.
Published: March 2023

Контроллинг, координируя, интегрируя и направляя деятельность всей системы управления предприятием на достижение поставленных целей, выполняет функцию «управления управлением» и является синтезом планирования, учета, контроля, анализа, организации информационных потоков и т.д. Занимая особое место в системе управления предприятием, контроллинг осуществляет информационное обеспечение принятия решений в целях оптимального использования имеющихся возможностей, объективной оценки сильных и слабых сторон предприятия, а также во избежание банкротства и кризисных ситуаций. Решение этих задач предполагает использование принципов антикризисного управления, а также наиболее прогрессивных концепций менеджмента в области финансов и маркетинга. Одной из наиболее современных, перспективных концепций управления предприятием и является контроллинг.

Бақылау, кәсіпорынды басқарудың бүкіл жүйесінің қызметін үйлестіре, біріктіре және алға қойылған мақсаттарға жетуге бағыттай отырып, "басқаруды басқару" функциясын орындайды және жоспарлау, есепке алу, бақылау, талдау, ақпараттық ағындарды ұйымдастыру және т. б. синтезі болып табылады. Кәсіпорынды басқару жүйесінде ерекше орын ала отырып, бақылау қолда бар мүмкіндіктерді оңтайлы пайдалану, кәсіпорынның күшті және әлсіз жақтарын объективті бағалау, сондай-ақ банкроттық пен дағдарыстық жағдайларды болдырмау мақсатында шешімдер қабылдауды ақпараттық қамтамасыз етуді жүзеге асырады. Бұл міндеттерді шешу дағдарысты басқару принциптерін, сондай-ақ қаржы және маркетинг саласындағы менеджменттің ең прогрессивті тұжырымдамаларын қолдануды қамтиды. Кәсіпорынды басқарудың ең заманауи, перспективалы тұжырымдамаларының бірі-бақылау.

Controlling, coordinating, integrating and directing the activities of the entire enterprise management system to achieve its goals, performs the function of "management management" and is a synthesis of planning, accounting, control, analysis, organization of information flows, etc. Occupying a special place in the enterprise management system, controlling provides information support for decision-making in order to make optimal use of available opportunities, an objective assessment of the strengths and weaknesses of the enterprise, as well as to avoid bankruptcy and crisis situations. The solution of these tasks involves the use of anti-crisis management principles, as well as the most progressive management concepts in the field of finance and marketing. Controlling is one of the most modern, promising concepts of enterprise management.
Экономические и правовые вопросы транспортной политики Республики Казахстан
Authors: ОМАРОВА А.Б.
Published: March 2023

Қазіргі уақытта Қазақстанда демократиялық мемлекеттің құқықтық негізін құру үрдісі жүргізілуде. Қазақстан Республикасының Конституциясында бекітілген құқықтық қатынастарды реттеуші заңның жоғары тұруы қоғамдық өмірдің барлық қырларын, соның ішінде көліктік қатынастарды да реттейтін заңнамаларда көрініс табуы тиіс. Мəселен, көлік саласында алуан түрлі, айрықша, əлі де зерттелмеген қатынастар туындайды. Мұндай қатынастарды құқықтық реттеу өзекті мəселе болып табылады. Тəуелсіздігімізді алғалы бері нормативтік-құқықтық актілер жаңадан қабылданып, заңды күшіне енгізіліп жатыр. Соған сəйкес көлік кешенінің нормативтік-құқықтық негізі нарықтық экономикаға сəйкес құрылып жатыр. Сондықтан бұл үрдіс аяқтала қойған жоқ, əлі де жетілдірілу үстінде деп айтуымыз керек. Бірақ, өкінішке орай, осы күнге дейін көлік құқығы теориясының көптеген өзекті мəселелі сұрақтары ғылыми негізделмеген жəне ғалымдардың көзқарастары қарама-қайшы күйінде қалып отыр.

В настоящее время в Казахстане идет процесс создания правовой основы демократического государства. Верховенство закона, регулирующего правоотношения, установленное Конституцией Республики Казахстан, должно найти отражение в законодательстве, регулирующем все стороны общественной жизни, в том числе и транспортные отношения. Например, в сфере транспорта возникают различные, особенно, еще не изученные отношения. Правовое регулирование таких отношений является актуальным вопросом. За годы независимости были приняты и вступили в законную силу нормативные правовые акты. Соответственно, нормативно-правовая база транспортного комплекса создается в соответствии с рыночной экономикой. Поэтому надо сказать, что этот процесс еще не завершен, он еще совершенствуется. Но, к сожалению, и по сей день многие актуальные вопросы теории ПДД не имеют научного обоснования, а взгляды ученых остаются противоречивыми.

Currently, Kazakhstan is in the process of creating the legal basis for a democratic state. The rule of law governing legal relations, established by the Constitution of the Republic of Kazakhstan, should be reflected in the legislation regulating all aspects of public life, including transport relations. For example, in the field of transport, various relations, especially those that have not yet been studied, arise. The legal regulation of such relations is a topical issue. During the years of independence, normative legal acts were adopted and entered into force. Accordingly, the regulatory and legal framework of the transport complex is being created in accordance with the market economy. Therefore, it must be said that this process has not yet been completed, it is still being improved. But, unfortunately, to this day, many topical issues in the theory of traffic rules have no scientific justification, and the views of scientists remain controversial.
The use of hypothesis testing in transport research
Authors: Kent Jonathan , Wallbank Caroline
Published: March 2023

Hypothesis testing is a well-used statistical method to evaluate whether a proposition is true or false. A fundamental part of the testing procedure is the calculation and interpretation of a p-value, which represents the probability of a set of data being observed, under the assumption that the proposition is true. This null hypothesis is then rejected if the p-value is less than a certain threshold, usually 0.05. In recent years, some members of the scientific community have called into question the validity of the hypothesis testing approach, because it places so much emphasis on whether or not a value is above or below an arbitrary threshold. We think that hypothesis testing is still a valid method, but it is important that, as well as the p-value additional information such as effect sizes is taken into account when interpreting results. In addition, there are alternative approaches, such as equivalence testing or Bayesian hypothesis testing, which should be considered in certain circumstances.
An Examination of the Implications of Transformative Leadership on the Perceptions Towards the Workplace
Authors: Dhiman Aashish , Vashistha Neha
Published: March 2023

The purpose of this research is to assess the role of transformative leadership on perceptions of faculty members towards the workplace. Workplace perceptions refer to how individuals feel, believe, and behave in various aspects of their work, environment, and colleagues. This study seeks to differentiate the perceptions of faculty members working in private and government institutions/colleges in the Ghaziabad District, Uttar Pradesh. Satisfaction at the workplace and commitment towards the workplace are the two variables considered for the study. This study is based on survey data from 160 faculty members using the Likert Scale. A chi-square test was used to test the effect of transformational leadership on workplace perceptions. The correlation coefficient is used to explore the association between perceptions of faculty members. Responses were collected through subjective sampling and analysis. In line with prior research, transformative leadership is found to have a significant impact on satisfaction and commitment toward the workplace. It is revealed in this study, that transformative leadership (TL) has a significant effect on the perception of the workplace of faculty members working in both Private and Government Institutes. The study also examined the correlation between the faculty members of private and government institutes and presented an adverse association between the two. The results cannot be generalized to other parts of the state/country and elsewhere as they are limited to a specific region only due to different policies and mindsets of the employees that differ from place to place.
Micronutrients Why and How
Authors: Koleilat Aziz
Published: March 2023

Nutrition is one of the important factors that affect the immune system. The key nutrients for a healthy immune system are proteins, antioxidants, micronutrients, prebiotics, and probiotics. The only food that has all the nutrients needed by the body is breastmilk. Breastmilk is not sterile since it has its own microbial composition. It helps in the development of a breastfed infant’s gut microbiome.
Peptic Ulcer Disease and Its Implications
Authors: John Umaru Isaac
Published: March 2023

Peptic ulcer disease (PUD) is one of the commonest diseases seen throughout the world. Peptic ulcers are open sores that develop on the inside lining of your stomach and the upper portion of your small intestine. The most common symptom of a peptic ulcer is stomach pain. There are various risk factors for the development of peptic ulcer disease, but the most important ones are Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs (NSAIDs). Patients generally present with dyspepsia or peptic ulcer bleeding. Acid suppressant therapy, H. pylori eradication, and avoidance of nonsteroidal anti-inflammatory drugs are the cornerstones of treatment of peptic ulcer disease. Peptic ulcer bleeding could be life-threatening. It is managed by appropriate supportive care, intravenous proton pump inhibitor therapy, and endoscopic homeostasis. Trans arterial embolization (TAE), Herbal treated and surgery are rarely required if endoscopic therapy fails.
Analytical Method Development and Validation of Hptlc Method for Simultaneous Estimation of Telmisartan and Azelnidipine in Tablet Dosage Form
Authors: Dhruv Ashwini
Published: March 2023

Background: A specific, accurate, precise, robust and cost effective HPTLC method was developed and validated for quantitative analysis of Telmisartan and Azelnidipine in fixed dose combination. The separation was carried out on pre-coated TLC plates with Silica gel 60 F254 as stationary phase using Chloroform: Ethyl acetate: Methanol (7.5:2:0.5 v/v/v) as developing system followed by densitometry measurement of bands at 280nm. Result: The separation of Telmisartan and Azelnidipine was found to be at the following RF values 0.3 and 0.63 respectively. Calibration curves were found to be linear over the concentration ranges 400-4000ng/band, 80-800ng/band for Telmisartan and Azelnidipine with correlation coefficient 0.9957 and 0.9966 respectively. Accuracy was found between 98.03% - 102% and 98.72% - 102 % for Telmisartan and Azelnidipine respectively. LOD was found to be 1.04% and 1.6% and LOQ was found to be 3.49% and 5.57% for Telmisartan and Azelnidipine respectively Conclusion: The results showed that the proposed HPTLC method is reliable for routine analysis for simultaneous determination of Telmisartan and Azelnidipine without any interference.
A Comparitive Study of Detection of Serum Total and Direct Bilirubin by Jendrassik & Grof and Automated Method
Authors: kaur Sukhraj
Published: March 2023

Background: Bilirubin is one of the major bile pigments, clinically and biologically important among the bile pigments present in the mammals. Material and Methods: The cross-sectional study was conducted in department of biochemistry in the collaboration with department medicine in Civil Hospital Tarn Taran. Out of 90 patients, 54 were males and 36 were females. Result: The comparison of Serum Total and Direct bilirubin by Jendrassik & Grof and Automated method was non-Significant with p value = 0.7788and 0.5394 respectively. The comparison of Serum Total and Direct bilirubin by Malloy Evelyn and Automated method is Highly Significant with p value =0.0002 and 0.0003 respectively. The mean difference of malloy with jendrassik & grof and automated was 2.394 and 2.162 respectively and the mean difference of jendrassik & grof with automated methodwas -0.231. Conclusion: It was concluded that a good correlation is found between bilirubin detection by manual and automated method. Non-significant mean difference between Jendrassik & Grof and Automated makesit better than Malloy Evelyn.
Characteristics of a Case Series of Long Covid-19 In General Medicine from March 15, 2020 to October 31, 2022, In Toledo, Spain
Authors: Luis Turabian Jose
Published: March 2023

Background Previous epidemiological studies of Long covid-19 have been difficult to interpret given the variety and heterogeneity of methods used, differences in the selection of patient populations and response rates, different follow-up periods and inconsistent terms used to describe symptoms. Objective To study in general medicine clinical-epidemiological characteristics of patients with Long covid-19 (presence of prolonged symptoms for at least 12 weeks, lasting at least 2 months, after acute covid-19 infection, and that are not explained by an alternative diagnosis). Methodology An observational, longitudinal and prospective case series study of patients with Long covid-19, based on a prospective cohort of covid-19 patients in a family medicine office in Toledo (Spain) was carried out from from March 15, 2020 to October 31, 2022. Results During the study period, 27 cases of Long covid-19 were included. The mean age was 48 years, 26% were >= 65 years and 4% <= 18 years; 48% were women; 11% ethnic minority; 30% presented moderate-severe severity of primary infection (pneumonias) and hospitalization in acute phase; 56% had chronic diseases, being more frequent the Nervous and Senses group (20%), Endocrine (17), and Digestive system (14%); 52% presented acute infection during 2021; Only 4% were not vaccinated with any dose. Regarding Long covid-19 symptoms, 27% were respiratory [4 chronic cough, 7 dyspnea, 1 chest pain], 20% ENT [5 rhinitis, 2 chronic sore throat, 1 epistaxis, 1 anosmia/ageusia], and 18% Neurological [5 headaches, 1 dizziness, 2 paresthesias in lower limbs] Conclusion In the context of general medicine in Toledo (Spain), patients with Long covid-19 were predominantly middle-aged, had been admitted to hospital for moderate-severe severity of primary infection, were vaccinated, and had preferably respiratory symptoms. It is estimated that 50% of the cohort had been infected with alpha or delta variants.
TERT Promoter Mutation c.-124C>T Commonly Occurs in Low-Grade Fibromatosis-like Metaplastic Breast Carcinoma
Authors: Webersinke Gerald , Burghofer Jonathan , Malli Theodora , Rammer Melanie , Jahn Stephan Wenzel , Niendorf Axel , Tavassoli Fattaneh A. , Moinfar Farid
Published: March 2023

Context.—

Low-grade fibromatosis-like metaplastic carcinoma (FLMC) is a very rare subtype of triple-negative metaplastic (spindle cell) breast carcinoma. It is characterized by the proliferation of spindle cells closely resembling fibromatosis, which represents a benign fibroblastic/myofibroblastic breast proliferation. Unlike most triple-negative and basal-like breast cancers, FLMC has a very low potential for metastases, but demonstrates frequent local recurrences.

Objective.—

To genetically characterize FLMC.

Design.—

To this end, we analyzed 7 cases by targeted next-generation sequencing for 315 cancer-related genes and performed comparative microarray copy number analysis in 5 of these cases.

Results.—

All cases shared TERT alterations (6 patients with recurrent c.-124C>T TERT promoter mutation and 1 patient with copy number gain encompassing the TERT locus), had oncogenic PIK3CA/PIK3R1 mutations (activation of the PI3K/AKT/mTOR pathway), and lacked mutations in TP53. TERT was overexpressed in all FLMCs. CDKN2A/B loss or mutation was observed in 4 of 7 cases (57%). Furthermore, tumors displayed chromosomal stability, with only few copy number variations and a low tumor mutational burden.

Conclusions—

We conclude that FLMCs typically show the recurrent TERT promoter mutation c.-124C>T, activation of the PI3K/AKT/mTOR pathway, low genomic instability, and wild-type TP53. In conjunction with previous data of metaplastic (spindle cell) carcinoma with and without fibromatosis-like morphology, FLMC is most likely distinguished by TERT promoter mutation. Thus, our data support the notion of a distinct subgroup within low-grade metaplastic breast cancer with spindle cell morphology and associated TERT mutations.
EU Market Monitoring Survey: Analysis of Loans, Credit and Credit Cards Industry
Authors: Khachatryan Mare V. , Kalantaryan Hayk L.
Published: March 2023

EU Market Monitoring Survey (MMS) is conducted by the European Commission for a range
of different industries to capture the patterns of consumer experience and enable the analysis of industry satisfaction based on core and industry specific indicators. MMS is designed to reveal how different markets and industries perform considering the consumer's perspective to the extent possible in terms of financial and human resources. The three broadly defined pillars of the survey for the EU27 plus Iceland, Norway and the UK consist of indicators related to (I) trust and confidence in traders, (II)choosing products and services, (III) and the in-market experience. While market-specific indicators are a reasonable way to differentiate between industries, the gap between industries in terms of consumer satisfaction and in terms of market-specific indicators might create a comparability constraint.
Impact of Eurasian Economic Union on trade activity
Authors: Kalantaryan Hayk L.
Published: March 2023

Eurasian Economic Union started its operation as a customs union in 2011 and moved towards a deeper integration by establishing an economic union in 2015. The Union consists of Armenia, Belarus, Kazakhstan, the Kyrgyz Republic, and Russia. The personality of the union is internationally recognized and established by the Treaty on the Eurasian Economic Union. The Treaty defines the purposes of the agreement as stable economic development, the creation of common and harmonized markers for goods and services and boosting the global competitiveness within the trade bloc members. It covers an economic area of $2,045 trillion GDP, 183.6 million people and is a major hub of oil, gas, and power generation. The economic area is also notable for its agriculture production which reaches 136 billion USD.
ՀՀ ապահովագրական ոլորտում ինշուրտեխ թվային նորարարությունների ներդրման հնարավոր ուղղությունները / The Possible Directions of Implementation of Insurtech Digital Innovations in the Insurance Sector of RA
Authors: Karapetyan Suren H.
Published: March 2023

In the course of research, the essence of insurance was revealed, the KPIs of RA insurance companies were analyzed. On the basis of academic literature, the features of RA insurance companies are evaluated and highlighted. As a result of the research, it was revealed that, despite the great progress in the digitalization of the RA financial sector, similar technologies do not have large application volumes in the insurance sector. Moreover, there are already fintech companies in the financial sector of RA, and the technological community of RA has accumulated a lot of experience in the field of financial technologies. It is emphasized that the insurance sector of RA needs to be re-equipped, taking into account the comfort of the user.
The purpose of the article is to identify and indicate possible directions of implementation of digital innovations in the insurance sector of RA.
The article may be of interest to insurance industry policy makers, analysts and representatives of tech companies.
Tin halide perovskites: computational modeling of structural, electronic and thermodynamic properties towards solar cell applications
Authors:   , Paschal Catherine
Published: March 2023

In the photovoltaic field, significant attention has been drawn to lead organo-halide perovskite materials because of their higher ability to convert sun energy to electricity and relatively simple process of fabrication as compared to silicon materials. Among the issues which hinder the lead perovskites solar cells (PSCs) application, are lead toxicity and instability of the PSCs in presence of moisture and light. The tin perovskites are thought over as the foremost fitting substitute due to their comparable chemical nature and high-power conversion efficiency. In this work, the methylammonium tin iodide CH3NH3SnI3 (MASnI3) and guanidinium tin halides C(NH2)3SnX3 (GUASnX3), X = Cl, Br, I, are considered; the electronic, structural as well as thermodynamic properties of the perovskites’ orthorhombic phase (O-phase) have been investigated using various theoretical DFT approaches. For the MASnI3, a direct band gap has been proved; in gamma symmetrical point of the band structure, the band gap value Eg is computed using three different exchange-correlation (XC) functionals: LDA 0.46 eV, PBEsol 0.98 eV and for PBE 1.12 eV; the best result has been obtained with the PBE which follows from the comparison of the computed Eg and lattice parameters with available experimental data. The enthalpy of the decomposition reaction of the MASnI3 into the solid-state materials, SnI2 and CH3NH3I, with reaction enthalpy, ΔrH°(0 K) = 37 kJ mol–1 , and enthalpy of formation ΔfH°(CH3NH3SnI3, 0 K) = –390 kJ mol–1 , have been evaluated showing the stability of the O-phase perovskite at low temperature. For the guanidinium-tin perovskites GUASnX3, the lattice parameters are optimized using the GGA PBE functional. Computations of the materials’ band structures was carried out, and band gaps at the gamma symmetry points were obtained: 3.00, 2.47 and 1.78 eV for the C(NH2)3SnCl3, C(NH2)3SnBr3 and C(NH2)3SnI3, respectively. The projected state densities are visualized, and the s-and p-states contribution of the halogens and tin to valence and conduction bands of the perovskites assessed. For the GUASnX3 compounds, the thermodynamic stability to different decomposition routes is examined, the standard enthalpies of formation are obtained: –673 (GUASnCl3), –541 (GUASnBr3), and –401 kJ mol–1 (GUASnI3). The interface between the hole transport material Cu2O and perovskite MASnI3 has been built and analyzed; the predicted binding energy shows strong binding between the two layers.
The Evolution, Formation and Development of Namatala Slum of Mbale Municipality, Uganda
Authors: Manana Mary, N. G.
Published: March 2023

Namatala, is the largest slum in the industrial division of Mbale Municipality in Eastern Uganda, having depicted the strongest patterns of urban infill and sprawl between 2003 and 2013.  The aim of this paper is to assess the evolution, formation, and development of Namatala slum drawing attention to the various challenges in the slum area in order to develop a place-centered approach for considering sustainable development solutions. The study targeted households in the slum area collecting data through observation, survey questionnaires, key stakeholder interviews, and focus group discussions. It was found that Namatala is a significantly disadvantaged location; wrought with poverty, inadequate social amenities, poor housing, lack of solid waste management, lack of essential infrastructure, and inadequate access to clean water, safe sanitation facilities, and security of tenure. This problem is largely attributable to lack of place-specific policy implementation of the national policies and guidelines inappropriate regulation, dysfunctional land markets, unresponsive financial systems, and a fundamental lack of political will. More so, there is absence of the means for public engagement.
Continental magmatism abstracts, International Association of Volcanology and Chemistry of the Earth's Interior
Authors:   International Association of Volcanology and Chemistry of the Earth's Interior, anonymous
Published: March 2023

This publication is produced for the International Association of Volcanology and Chemistry of the Earth's Interior (IAVCEI) General Assembly held in Santa Fe, NM, on 25 June-1 July 1989. This contains over 600 abstracts pertaining to symposia on (1) North American cordilleran magmatism, (2) continental arcs, (3) extensional volcanism, (4) aqueous magmatic fluids, ore deposits, and geothermal systems, (5) active volcanism and hazards, and (6) volcanic and magmatic processes. 340 pp., 11 tables, 103 figs., 1 index.
Stratigraphic studies of the San Andres Mountains, New Mexico
Authors: Kottlowski Frank E. , Flower R. H. , Thompson M. L. , Foster R. W.
Published: March 2023

The San Andres Mountains in south-central New Mexico expose a section of Paleozoic sedimentary rocks unrivaled in New Mexico in length of continuous outcrop and in completeness of existing time-lithologic units. The thickness, lithology, and extent of the Paleozoic strata concealed in the nearby basins can be estimated accurately from the sections in the San Andres Mountains and from known sections in more accessible areas.

The Bliss Sandstone, El Paso Group, Montoya Group, Fusselman Dolomite, Devonian formations, Mississippian formations, Pennsylvanian beds, Bursum Formation, Hueco Formation, Abo red beds, Yeso Formation, San Andres Formation, Dockum Formation, Sarten Formation, Dakota Sandstone, Eagle Ford or Mancos Formation, and Love ranch Formation were measured and described in detail in Rhodes, Hembrillo, and Ash Canyons. Rhodes Canyon, the most accessible in the range, contains the northernmost complete section. Hembrillo Canyon, though difficult of access, is in the center of the range. Ash Canyon is the southernmost accessible canyon in which the formations have escaped intense deformation and metamorphism associated with intrusion of the Organ Mountains batholith.

Paleozoic sedimentary rocks measure a total of 7,065 ft in Rhodes Canyon, 6,519 ft in Hembrillo Canyon, and 7,130 ft in the Ash Canyon-Love ranch area. Pre-Pennsylvanian sedimentary rocks thicken southward from 858 ft in Rhodes Canyon, and 1,380 ft in Hembrillo Canyon, to 1,918 ft in Ash Canyon. Eighteen mi north of Rhodes Canyon, in Sly Gap, pre-Pennsylvanian strata are 674 ft thick. Pennsylvanian sedimentary rocks thicken and thin southward, and Permian beds thin, as do combined thicknesses of Pennsylvanian and Permian strata. The Abo red beds thin markedly southward, where they interfinger with marine beds of the Hueco Formation. Triassic beds occur only north of Rhodes Pass. Rocks of Jurassic age are not present anywhere in or near the San Andres Mountains. Upper Cretaceous sedimentary rocks in the adjoining basins thin southward, though Lower Cretaceous rocks, absent near Hembrillo Canyon and northward, appear near Love Ranch, and thicken south of the range.

The porous dolomites and dolomitized limestones of pre-Devonian age thin northward beneath a relatively uniform blanket of impervious Devonian shales and siltstones, but still are 509 ft thick in Sly Gap, near the north end of the range. The lower part of the Pennsylvanian strata, from Derryan to Missourian in age, thickens southward to Hembrillo Canyon, but thins abruptly in Ash Canyon; south and east of the San Andres Mountains it again thickens, but remains relatively thin to the west. The thick Virgilian sequence of the Pennsylvanian, named the Panther Seep Formation in this report, thickens southward and is lithologically different from rocks or correlative age outside of the range. Biohermal and biostromal reefs are common in the upper part of the Panther Seep beds north of Ash Canyon.
Middle Pennsylvanian brachiopods from the Mud Springs Mountains and Derry Hills, New Mexico
Authors: Gehrig John L.
Published: March 2023

A brachiopod fauna from carefully measured sections of the lower part of the Pennsylvanian in Sierra County, New Mexico, was studied to determine if the megafossils could be useful in designating and correlating the various units of the Pennsylvanian in this area.

It was found that strata belonging to the Derry and the Des Moines series could be distinguished on the basis of the contained brachiopod species. Several characteristic species from the Derry, which is believed to be younger than the Morrow of the mid-continent region, are similar to upper Mississippian forms. Brachiopods of the Bolander Group in the upper part of the Desmoinesian show close affinities with those of the Marmaton Group of Kansas. It thus appears that both megafossils and microfossils can be used successfully to distinguish groups and series in the Pennsylvanian of New Mexico.

Sedimentary rocks of Pennsylvanian age are widespread in New Mexico both on the surface and in the subsurface. They are particularly important as a source of petroleum and natural gas, and in the western part of the State they contain mineral deposits. They vary greatly from place to place in the proportions of sandstone and shale to carbonates; yet they are commonly more than 1,000 ft in total thickness, so that the distinction of units which can be recognized in outcrops or in drill holes is of economic importance.

Thompson measures a number of sections and divided the strata into series, groups, and formations. The age determinations and the correlations of these units with the standard section of the mid-continent region were based in large part upon the microfossil content. In many localities, mega fossils, particularly brachiopods, are abundant. The purpose of this study was to determine whether or not the brachiopods could be used to distinguish units within the Pennsylvanian.

In the summer of 1953, Thompson's sections in the vicinity of Derry on the Rio Grande, 30 mi south of Truth or Consequences, and at Whiskey Canyon in the Mud Springs Mountains, 7 mi northwest of Truth or Consequences, were remeasured, and both megafaunas and microfaunas collected. These collections represent the Green Canyon and Mud Springs Groups of the Derry series and the Armendaris and Bolander Groups of the Des Moines series. The brachiopods are described and illustrated in this report, and their stratigraphic relationship to the Fusulinidae is recorded. All figured specimens are in the collection of the New Mexico Bureau of Mines and Mineral Resources at Socorro; the remainder were left at the University of Wisconsin, where the laboratory studies were completed.