bluuebunny/crossref_metadata_2025 huggingface dataset:
Increasing trends of pharmaceutical payments to breast cancer specialists in Japan: A retrospective study from 2016 to 2019
Authors: Kaneda Yudai , Yamashita Erika , Saito Hiroaki , Gonda Kenji , Wada Masahiro , Tanimoto Tetsuya , Ozaki Akihiko
Published: September 2024

Introduction

The introduction of new drugs often leads to aggressive promotion and potential financial conflicts of interest, which may bias treatment decisions and potentially harm patients. The breast cancer therapeutics market is rapidly evolving globally, and Japan is no exception. This study aimed to analyze trends in pharmaceutical payments to breast cancer specialists in Japan from 2016 to 2019, focusing on company-level data, relationships with new drug introductions, and individual specialist payment patterns.

Methods

This retrospective study examined financial relationships between pharmaceutical companies and breast cancer specialists in Japan from 2016 to 2019. The analysis focused on certified specialists as of May 2023 and used payment data from 93 pharmaceutical companies for activities such as lecturing, writing, and consulting. First, a company-level analysis examined total payments, categories, and trends for all companies and the top 10 individually; second, a specialist-level analysis looked at payment amounts amount and counts. The Gini index was employed to assess the concentration of payments among specialists.

Results

Total payments reached USD 13,329,911, growing at 10.1% annually, with 81.4% allocated to lecturing engagements. The top 10 companies, led by Chugai Pharmaceutical, Eisai, and AstraZeneca, accounted for 89.5% of all payments. Companies like Pfizer Japan and Eli Lilly Japan saw notable increases following the introduction of new drugs such as palbociclib and abemaciclib. Payment distribution was highly skewed, with an average of $7,692 per specialist but a median of only $2,884. A Gini index of 0.994 further confirmed that a small group of specialists received a disproportionately large share of the payments

Conclusion

From 2016 to 2019, pharmaceutical payments to Japanese breast cancer specialists increased significantly, coinciding with new drug introductions. The concentration of payments among a select group of specialists raises concerns about potential influences on clinical decision-making and guideline recommendations.
Upstream factors impacting COVID-19 vaccination rates across Africa: A systematic review protocol
Authors: Ezezika Obidimma , Kotsaftis Tiana Stephanie , Marson Alanna
Published: September 2024

Background

Upstream factors have been found to affect COVID-19 vaccination rates and coverage globally. However, there are inadequate details within the African context. This systematic review aims to close this research gap by investigating upstream factors influencing COVID-19 vaccination rates in Africa.

Methods

A literature search will be systematically conducted utilizing various databases including: MEDLINE, EMBASE, SCOPUS, CINAHL, Web of Science, and PsycINFO. Eligible studies will include peer-reviewed articles published in the English language from 2020–2023, conducted in Africa, focused on upstream factors, and include one barrier or facilitator to COVID-19 vaccination rates. Two reviewers will use a two-step screening process to examine every article’s title, abstract, and full text. A third-party reviewer will resolve disagreements between both individual reviewers. This review will focus on extracting data from published studies to explain the upstream factors included and their impact on COVID-19 vaccination rates across Africa. Data and records will be managed using Covidence. Preferred Reporting Items for Systematic Reviews and Meta-Analyses [PRISMA] framework will be used as the basis for reporting. To reduce bias, the researchers will use the Mixed Methods Appraisal Tool to assess the studies chosen for review. Results will be compiled utilizing four tables to summarize articles and group determinants based on the Consolidated Framework for Implementation Research (CFIR).

Discussion

Upstream factors have been cited as affecting population health, vaccination programs, and COVID-19, yet a large-scale systematic review has not been conducted to investigate these factors in relation to COVID-19 vaccination disparities faced in Africa. This review aims to analyze the root causes of African vaccination disparities by focusing on upstream factors. Understanding these factors is vital to help explain why these disparities occur and for designing effective interventions for future vaccinations. The results are expected to provide insights for researchers, policymakers, health systems, and individuals by identifying how resources and efforts can be better utilized to improve vaccination uptake and access.

Trial registration

Systematic review registration: CRD42024501293.
TFAB002s, novel CD20-targeting T cell-dependent bispecific Fab-FabCH3 antibodies, exhibit potent antitumor efficacy against malignant B-cell lymphoma
Authors: Li Qinghong , Zhang Kunming , Yu Yao , Yu Zeng , Xu Jingyi , Shen Wenyan , Zhang Lin , Qu Aidong , Liang Hongyuan
Published: September 2024

B-cell lymphoma, clinically, comprises a heterogeneous group of malignancies that encompass various subtypes. CD20 is an optimal target for therapeutic antibodies in B-cell lymphoma immunotherapy since approximately 90% of B-cell malignancies typically exhibit CD20 expression on their surface, while its presence is limited in normal tissues. In this study, we have developed a series of novel non-IgG-like T cell-dependent bispecific antibodies by constructing Fab-FabCH3, referred to as Tandem Antigen-binding Fragment 002 (TFAB002), which specifically target CD20 for the treatment of malignant B-cell lymphoma. TFAB002s display strong binding affinity with CD20 and moderate binding affinity with CD3, thereby triggering target-specific T-cell activation, cytokine release, and tumor cell lysis in vitro. Furthermore, TFAB002s exhibit potent cytotoxicity against B-cell malignancies that express varying levels of CD20. Besides, the TFAB002s show potent pharmacodynamic activity in vivo in the WIL2-S cells CDX mouse model. Collectively, these results underscore the potential of TFAB002s as a highly promising therapeutic approach for selectively depleting CD20-positive B cells, thereby warranting further clinical evaluation as a viable treatment option for CD20-expressing B-cell malignancies.
Risk factors for urinary tract infection in elderly patients with type 2 diabetes: A protocol for systematic review and meta-analysis
Authors: Jia Hairong , Su Wenhao , Zhang Jiaqi , Wei Zhaoyang , Tsikwa Pepertual , Wang Yanru
Published: September 2024

Introduction

Type 2 diabetes mellitus (T2DM) is a frequent chronic condition among the elderly, which increasing their susceptibility to infection. Urinary tract infection (UTI) is one of the most prevalent infections among older people with T2DM. However, the association between geriatric T2DM and the risk of UTI has not been thoroughly researched and is still contentious. Consequently, this protocol describes a systematic review to pinpoint the primary risk factors for UTI among elderly T2DM. Our goal is to improve recommendations for the creation of targeted treatment interventions by examining risk factors for UTI in elderly individuals with T2DM.

Methods and analysis

We will search 4 English literature databases (PubMed, Embase, Web of Science, and Cochrane Library) and 3 major Chinese databases (CNKI, WanFang, and VIP) from the establishment of the database to June 20, 2024. Systematic evaluation and meta-analysis will be conducted on cohort and case-control studies exploring the occurrence and risk determinants of UTI in individuals diagnosed with T2DM. The main focus will be on identifying the risk factors for UTI in elderly diabetic patients. Two researchers will independently review articles, collect data, and evaluate the quality and potential bias of study inclusion. We will use RevMan V.5.4 software to analyze the data. The quality of the included studies will be assessed using the Newcastle-Ottawa scale. In addition, the GRADE (Grade of Recommendations, Assessment, Development, Evaluation) method will be used to examine the quality of evidence for each exposure and outcome of interest.

Discussion

This study aims to illuminate the various risk factors associated with UTI in older patients diagnosed with T2DM. By this thorough investigation, we hope to provide a more comprehensive reference for medical professionals and researchers, thereby supporting the implementation of effective preventive strategies against UTI and improving overall nursing outcomes for this specific patient population.

Trail registration

PROSPERO (CRD42024559129).
Factors affecting seeking psychological and psychiatric support for Turkish society
Authors: Çebi Karaaslan Kübranur , Karaaslan Abdulkerim , Subaşı Hüriye
Published: September 2024

The increase in mental health issues and awareness among individuals, compared to previous times, has contributed to recognizing this as a significant public health issue. The necessity to explore potential factors behind mental health problems has become paramount and served as the primary impetus for the current research endeavor. This study aims to explore if there is a relationship between attitudes toward seeking psychological and psychiatric support. a significant relationship between sociodemographic factors and individuals’ tendency to seek psychological and psychiatric help, and if so, in what direction are these relationships? and a significant relationship between individual and social factors and individuals’ tendency to seek psychological and psychiatric help, and if so, in what direction are these relationships? Microdata from the Turkey Health Survey, conducted by the Turkish Statistical Institute and representative of Turkey, was used as the dataset. Increased the representative power of the data set over the universe by weighting the data set, and the Bivariate Probit Model was used to address the research questions. As a result of the study, various sociodemographic (gender, age, employment status, et al.), individual and social factors (general health status, participation in social activities, alcohol use et al.) may influence individuals’ inclinations toward seeking psychological and psychiatric assistance. The research offers valuable insights for social policymakers and researchers into the behavioral tendencies of individuals seeking professional psychiatric help.
HNL Dimer in plasma is a unique and useful biomarker for the monitoring of antibiotic treatment in sepsis
Authors: Venge Per , Peterson Christer , Xu Shengyuan , Larsson Anders , Johansson Joakim , Tydén Jonas
Published: September 2024

Introduction

Sepsis is a growing problem worldwide and associated with high mortality and morbidity. The early and accurate diagnosis and effective supportive therapy are critical for combating mortality. The aim of the study was to compare the kinetics of four biomarkers in plasma in patients admitted to ICU including sepsis and during antibiotics treatment.

Methods

The biomarkers evaluated were HBP (Heparin-binding protein), HNL Dimer (Human Neutrophil Lipocalin), HNL Total and PCT (Procalcitonin). Plasma was obtained at admission to ICU and during follow-up at days 2 and 3. Antibiotic treatment was started or reviewed on admission to ICU. The results were compared to SOFA and KDIGO-scores and to survival. 277 patients admitted to ICU were included of which 30% had sepsis. The other groups were categorized as miscellaneous, other medical and trauma.

Results

The plasma concentrations of all four biomarkers were highly elevated with the highest concentrations in sepsis patients. During the follow-up period HNL Dimer decreased already day 2 and further so day 3 (p<0.00001) in contrast to unchanged concentrations of the other three biomarkers. HNL Total showed the strongest relationships to the clinical scores (p<0.0001) and was by multiples regression analysis independently related to these scores.

Conclusion

Our data supports and confirms our earlier findings of HNL Dimer being a novel and potentially useful clinical tool in antibiotic stewardship in sepsis. HNL Total reflects epithelial cell activity in the body and is an interesting biomarker for the management of organ failure in such patients.
DNA methylation profiling identifies TBKBP1 as potent amplifier of cytotoxic activity in CMV-specific human CD8+ T cells
Authors: Yu Zheng , Sasidharan-Nair Varun , Buchta Thalea , Bonifacius Agnes , Khan Fawad , Pietzsch Beate , Ahmadi Hosein , Beckstette Michael , Niemz Jana , Hilgendorf Philipp , Mausberg Philip , Keller Andreas , Falk Christine , Busch Dirk H. , Schober Kilian , Cicin-Sain Luka , Müller Fabian , Brinkmann Melanie M. , Eiz-Vesper Britta , Floess Stefan , Huehn Jochen
Published: September 2024

Epigenetic mechanisms stabilize gene expression patterns during CD8+ T cell differentiation. Although adoptive transfer of virus-specific T cells is clinically applied to reduce the risk of virus infection or reactivation in immunocompromised individuals, the DNA methylation pattern of virus-specific CD8+ T cells is largely unknown. Hence, we here performed whole-genome bisulfite sequencing of cytomegalovirus-specific human CD8+ T cells and found that they display a unique DNA methylation pattern consisting of 79 differentially methylated regions (DMRs) when compared to memory CD8+ T cells. Among the top demethylated DMRs in cytomegalovirus-specific CD8+ T cells was TBKBP1, coding for TBK-binding protein 1 that can interact with TANK-binding kinase 1 (TBK1) and mediate pro-inflammatory responses in innate immune cells downstream of intracellular virus sensing. Since TBKBP1 has not yet been reported in T cells, we aimed to unravel its role in virus-specific CD8+ T cells. TBKBP1 demethylation in terminal effector CD8+ T cells correlated with higher TBKBP1 expression at both mRNA and protein level, independent of alternative splicing of TBKBP1 transcripts. Notably, the distinct DNA methylation patterns in CD8+ T cell subsets was stable upon long-term in vitro culture. TBKBP1 overexpression resulted in enhanced TBK1 phosphorylation upon stimulation of CD8+ T cells and significantly improved their virus neutralization capacity. Collectively, our data demonstrate that TBKBP1 modulates virus-specific CD8+ T cell responses and could be exploited as therapeutic target to improve adoptive T cell therapies.
Effects of deficit irrigation on potato yield and water productivity in northern Ethiopia
Authors: Teshome Aemro Wale , Wosenie Mekete Dessie , Addis Hailu Kendie
Published: September 2024

In northern Ethiopia, potatoes are frequently cultivated with excessive irrigation water. Water is a scarce and expensive resource in semi-arid environments, so it is critical to create irrigation technology that enhances water efficiency and availability, as well as to implement better irrigation management methods. A field experiment was conducted for the years in 2018/19 and 2019/20 to investigate the effects of water deficit on potato yield, water productivity, and net income. Deficit irrigation treatments affected yield and yield-related components, but were not statistically different in all cases. Each treatment had important effects on tuber yield, water productivity, and plant height. Tuber yield was best in the non-deficit treatments (T1). In most cases, the variations in tuber production and plant height between initial, late season (25% deficit), other stages with full demand, and non-deficit treatments were small and statistically insignificant. The highest water productivity and irrigation water productivity were obtained at 25% deficit treatment (T3) in the initial and late-season stages. Under limited land and water, the 25% deficit treatment (T3) offered the best net financial benefits in initial and late season stages of potato production. These findings are valuable for making policy decisions about appropriate irrigation and water management under water-stressed conditions that maximize net economic benefits from limited land and water resources.
Universal Algebraic Survey of C∞-Rings
Authors: Cerqueira Berni Jean , Luiz Mariano Hugo
Published: September 2024

This survey brings a detailed and systematic exposition of some fundamental results regarding the Universal Algebra of C∞−rings. Some of these were nowhere to be found – stated or proved – in the current literature. Our main contribution is to bundle these results up in a single text, using the unifying language of Universal Algebra and referring the reader to detailed proofs. Such a presentation is inspired by the treatment given by D. Joyce in [1] to some concepts involving these rings. Thus, we provide a comprehensive material with many known “taken for granted” results and constructions used everywhere in the literature about C∞−rings and their applications, providing a “propaedeutic exposition” for the reader’s benefit.
The equality between ε(f ) and δ(f ) proved via Newton polygons
Authors: Silva de Souza Caio Henrique
Published: September 2024

In this paper, we reproduce the proof given in [1] of the equality be- tween ε(f) and δ(f), two important objects in Valuation Theory. This proof uses the notion of Newton polygons. We present some details that were omitted in [1] and illustrate a step-by-step construction of a Newton Polygon associated to a specific finite set.
Difficult to Pass: Cholangitis With Vertical Band Stenosis
Authors: Abrol Robinder , Mushtaq Muhammad , Muftah Abdullah , Samreen Sarah , Yang Juliana
Published: September 2024

As techniques have been refined, more patients in the United States have undergone bariatric surgery for weight loss. These surgeries alter the gastrointestinal tract to restrict caloric intake. While most surgeons prefer sleeve gastrectomy and Roux-en-Y gastric bypass, some older procedures, like vertical band gastroplasty, have fallen out of favor due to late complications. In any bariatric procedure, endoscopy can be challenging if indicated due to altered anatomy. Here, we present a case of challenging anatomy due to remote vertical band gastroplasty in a patient presenting with cholangitis, highlighting the effective use of a lumen-apposing metal stent across a vertical band stenosis.
Otimizando a Fiscalização de Serviços Contínuos de Dedicação Exclusiva: Uma Análise dos Manuais nos Institutos Federais de Minas Gerais
Authors: Dantas Isabela , Barbosa Agata Priscila , Alves Garcia Luan Augusto , De Castro Melo Daniela , Araújo Lima Danielli
Published: September 2024

Com a desburocratização do Estado, em 1995, verifica-se a prática da terceirização das atividades-meio como uma tática para que o Estado pudesse concentrar seus esforços nas funções principais. No entanto, é fundamental que as atividades terceirizadas sejam fiscalizadas pelo ente público, especialmente aquelas que envolvem serviços contínuos com dedicação exclusiva de mão de obra, em que o ente público assume responsabilidade subsidiária. Para garantir a eficiência e a supremacia do interesse público nesse cenário, a figura dos fiscais, tanto técnicos quanto administrativos, desempenha um papel imprescindível. Nesse contexto, o presente estudo propõe melhorias nos manuais de fiscalização disponíveis nos websites dos Institutos Federais de Minas Gerais. Foram avaliados 21 requisitos específicos, registrando-se o número de requisitos observados (atendidos) por instituto. A metodologia adotada consistiu em pesquisa documental com análise qualitativa. Os resultados revelaram uma variação considerável na quantidade de requisitos atendidos pelos diferentes institutos. Os requisitos mais atendidos dizem respeito às legislações apontadas; a conceitos relevantes; e à existência de materiais de apoio, como, por exemplo, o check-list. Em contrapartida, os requisitos relacionados aos procedimentos de fiscalização preventiva, rotineira e sistemática foram os menos atendidos, também, verificou-se instruções deficitárias em relação à comunicação com órgão auxiliares ou de controle interno. Como resultado da análise, foram propostas cinco melhorias para os manuais de fiscalização. Essa análise pode ser útil para identificar áreas que necessitem de aprimoramento na fiscalização de contratos e ressalta a importância de estabelecer padrões claros e objetivos para garantir transparência e efetividade nesse processo.
Application of Roy Adaptation Model: Using Artificial Intelligence-driven Immersive Virtual Reality As a Novel Technology for Cancer Pain Management among Patients with Advanced Breast Cancer
Authors:   Middle East University, Amman, Jordan, Kh. Alhusamiah, Bushra , Aldiqs Mohannad , Zeilani Ruqayya S
Published: September 2024

Background: Patients with advanced breast cancer often experience severe physical and psychological symptoms, including pain. Poor pain management is still prevalent despite the widespread availability of opioids as well as guidelines from the World Health Organization, professional training, and the availability of pain management alternatives. Consequently, researchers and healthcare practitioners have directed their efforts towards non-pharmacological approaches, such as artificial intelligence and virtual reality. Recently, AI technology has been used to develop advanced virtual reality systems that adapt and respond to human behavior in a highly intelligent and interactive manner. Purpose: This study aimed to structure a conceptual framework guided by the Roy Adaptation Model (RAM) for implementing AI-driven immersive VR in managing pain among patients with advanced breast cancer. Methods: A conceptual study framework was structured to use artificial intelligence-driven immersive virtual reality as a novel technology for pain management among patients with advanced breast cancer guided by the (RAM). Results: According to the proposed conceptual framework, it has been determined that healthcare providers can use the structured conceptual framework guided by the Roy Adaptation Model to adapt a nursing-based intervention, such as AI-driven Immersive VR for pain management among patients with advanced breast cancer. Adopting this intervention will help patients achieve a state of adaptation by addressing various modes of adaptation to manage pain, including physiological-physical mode, self-concept mode, role function mode, and independence mode. Conclusion: Roy Adaptation Model (RAM) is a highly valuable conceptual framework that plays a crucial role in guiding the use of artificial intelligence-driven immersive virtual reality as a novel technology for pain management among patients with advanced breast cancer. Implications for Nursing: By utilizing RAM, nurses can enhance their abilities to facilitate effective innovative nursing interventions such as artificial intelligence-driven immersive virtual reality for cancer pain management and to identify all of the related stimuli that directly lead to an increase in the intensity of cancer pain and have a significant influence on the effectiveness of the nursing intervention. Keywords: Breast cancer, Chronic cancer pain, Roy adaptation model, Artificial intelligence-driven immersive virtual reality
Richard Rohr and the Paradigm Shift in Trinitarian Theology
Authors: Heryán Ladislav
Published: September 2024

This paper describes Rohr’s shift from the traditional Trini-tarian theology to a new concept of God. Rohr sees Christ as the mysterious essence of all things. The Trinity is an expression of the flowing nature of the Divine. Jesus, through his cross, allowed suffer-ing to change him and the world, so that people could break out of the endless cycle of projecting pain elsewhere and be loved by the real-ity that surrounds them. The implications of this shift for spirituality are considered. People can live with constant prayer, meditation and practice of his words in his presence.
The “Theology” of Richard Rohr
Authors: Gallus Petr
Published: September 2024

Based on R. Rohr’s book The Universal Christ, this arti-cle presents a very critical review of Rohr’s „theology“. It focuses on Rohr’s crucial theological decisions, on his hermeneutics, his biblical interpretations and some important theological concepts as sin, evil, or christology. It sets Rohr’s view into a critical contrast to the tradition and current literature to particular topics. As concluded in the end, based on the reasons provided, the article doubts that Rohr’s propsal can stand to academic scrutiny.
Richard Rohr: Trinity, Christ, and Creation
Authors: Paluchníková Štěpánka
Published: September 2024

This article aims to present Richard Rohr’s Trinitarian and Christological approach in to the whole of creation. The Trinity as the basic structure of the cosmos is here the principal starting point for a dynamic process of „becoming“. The specific key in this approach is found in the theological meaning of „Christ in all and all.“ Although this Rohr‘s view of Christ is in many ways controversial, it undoubtedly brings a current challenge to man’s self-understanding in his relation-ship to this God-created world.
The Possibilities of Theory - the Theory of Possibilities
Authors: Woźniak-Czech Ewelina
Published: September 2024

This essay attempts to describe a new field of research in contemporary literary theory, defined in terms of performative, dramatic, and dramaturgical interactions and relations. The focus is placed on the dynamic movement of concepts and categories, as it allows theory to keep up with the constant new developments in literature and culture. These movements give rise to a dramatic discourse that replaces traditional methodologies. Such a transdisciplinary dialogue allows for a complex play of meanings. Any theory is a sum of choices made from among many possibilities, compatible approaches and ideas, and potential perspectives. In the new theoretical perspective described in this essay, no theory of a work of art is rejected and each remains valid, as long as it functions inclusively in a field of many different possibilities. The dramaturgy of concepts, the potential tensions and possible contradictions between them, which, paradoxically, are not mutually exclusive, complex plays and displacements, fractures and entanglements, open up new theoretical horizons. Indeed, we should ask whether the time of grand theories has passed or whether one of the most comprehensive literary theories is being created today, as it unites all past and future concepts involved in the study, interpretation, and reception of literature. It is the theory of possibilities.
Hyers-Ulam stability of Davison functional equation on restricted domains
Authors: Park Choonkil , Tareeghee Mohammad Amin , Najati Abbas , Noori Batool
Published: September 2024

In this article, we study the Hyers-Ulam stability of Davison functional equation

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on some unbounded restricted domains. Using the obtained results, we study an interesting asymptotic behavior of Davison functions. We also investigate the Hyers-Ulam stability of Davison functional equation and its generalized form given by

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Optimizing personalized treatments for targeted patient populations across multiple domains
Authors: Chen Yuan , Zeng Donglin , Wang Yuanjia
Published: September 2024

Learning individualized treatment rules (ITRs) for a target patient population with mental disorders is confronted with many challenges. First, the target population may be different from the training population that provided data for learning ITRs. Ignoring differences between the training patient data and the target population can result in sub-optimal treatment strategies for the target population. Second, for mental disorders, a patient’s underlying mental state is not observed but can be inferred from measures of high-dimensional combinations of symptomatology. Treatment mechanisms are unknown and can be complex, and thus treatment effect moderation can take complicated forms. To address these challenges, we propose a novel method that connects measurement models, efficient weighting schemes, and flexible neural network architecture through latent variables to tailor treatments for a target population. Patients’ underlying mental states are represented by a compact set of latent state variables while preserving interpretability. Weighting schemes are designed based on lower-dimensional latent variables to efficiently balance population differences so that biases in learning the latent structure and treatment effects are mitigated. Extensive simulation studies demonstrated consistent superiority of the proposed method and the weighting approach. Applications to two real-world studies of patients with major depressive disorder have shown a broad utility of the proposed method in improving treatment outcomes in the target population.
Verbal numeral classifiers in languages of Eastern Eurasia: A typological survey
Authors: Honkasalo Sami , Yurayong Chingduang
Published: September 2024

This article presents a typological survey of verbal numeral classifiers (VNCs) in languages of Eastern Eurasia. As classifiers of occurrence (e.g., to V once, to V twice), VNCs are prevalent in languages of East Asia and Southeast Asia, yet the phenomenon has been largely overlooked in typological studies that have overwhelmingly focused on the adnominal use of numeral classifiers. Analyzing a sample of 543 linguistic varieties, the study categorizes the language families of Eastern Eurasia into three groups based on their use of VNCs: 1) VNCs consistently present in all languages (e.g., Tai-Kadai); 2) VNCs present in some languages (e.g., Sino-Tibetan); and 3) VNCs consistently absent (e.g., Yukaghir). Additionally, the meanings of VNCs are shown to follow a non-random distribution by centering on certain semantic fields, such as quantifying hits with ‘verbs of violence’. The study aims to offer the first step toward an areal typological study of VNCs, highlighting the importance of including this phenomenon in future descriptive work.
“I Want to Judge! I Have to Judge!”: Judg-mentaility and the Theopolitics of the Apocalypse
Authors: Bielik-Robson Agata
Published: September 2024

The apocalyptic genre was from the beginning in the centre of the theologico-political discourse which, according to Jacob Taubes, always has to choose one of the two fundamental options: either in favour of the apocalypse (“from above,” as in early Schmitt, or “from below,” as in Taubes himself), or against it in the katechonic defense against the apocalyptic chaos and destruction (late Schmitt). In Taubes’s account, apocalypse is simultaneously revelatory and destructive. By assuming the standpoint of the Last Judgment, it passes an ultimate verdict without appeal over the world – as indeed in Taubes’s most famous statement: “I have no spiritual investment in the world as it is. I can imagine as an apocalyptic: let it come down.” It is precisely this form of position assuming the uncompromising perspective of the Last Judgment, which will occupy me in my essay. I want to approach critically the most recent phenomenon of what we may call an absolute judg-mentaility – or, in Nietzschean terms, a “mentality of judgment” – which takes apocalyptic form of a violent negation, exposing the whole “world as it is” to the scorching light of the verdict and leaving no space that would be free from adjudication.
The Affective Neuroscience Personality Scales (ANPS) in Slovenia: Validation of the Six Primary Scales Across Three ANPS Versions
Authors: Glavač Timotej , Zupančič Maja
Published: September 2024

To assess primary emotions in subcortical brain regions across all mammals, the affective neuroscience personality scales (ANPS) were created for use in research involving human subjects. Later revisions of the scales have been validated across many countries and are used in diverse fields of psychology. The ANPS revisions culminated in the most recent ANPS 3.1. In this study, we evaluated the psychometric properties of the ANPS 3.1 and its two abbreviated versions (affective neuroscience personality scales – brief (BANPS) and affective neuroscience personality scales – short version (ANPS-S)) in a Slovenian community sample of 502 young adults. We simultaneously examined several kinds of validity evidence across the three versions: construct validity, internal reliability, and convergent validity. Our findings revealed acceptable construct validity of the six-factor model of the BANPS that was superior to the ANPS-S and particularly to the ANPS 3.1. The latter exhibited incremental fit issues noted in previous versions. However, we revealed sufficient internal reliability and convergent validity of the scale scores against the Big Five personality traits, and the frequency of the participants’ recently felt positive and negative emotions across all three ANPS versions. Testing the measurement invariance of BANPS across sex suggested full metric invariance and partial scalar invariance which allows direct score comparisons between males and females.
An Analyst's Hallucination as a Manifestation of Osmotic Communication
Authors: Zalewska Justyna
Published: September 2024

This article conveys the psychoanalyst's hallucinatory experience during a session with a patient who experienced premature birth trauma. Engaging with the patient's primal fears of disappearance and confusion with the object through hallucinosis initiated the analyst's engagement with her own trauma. The concept of osmotic communication within the patient-analyst relationship is viewed as central to description and understanding of the primal dialogue of two unconscious minds. The filtration of psychic content from the patient's to the analyst's unconscious is facilitated by the semipermeable membrane of analyst's receptivity. As a recipient, the analyst embodies and processes the patient's unmentalized experiences in a transformative manner.
How War Is Rebordering Ukraine
Authors: Zhurzhenko Tatiana
Published: September 2024

Ukraine’s border regions have been long associated with the country’s cultural and linguistic diversity, but also with political cleavages and alternative geopolitical orientations. The annexation of Crimea by Russia and the military conflict in Donbas violently reshaped Ukraine’s eastern borderlands and led to alienation between the two countries. At the same time, the Ukraine-EU Association Agreement and visa-free regime facilitated the growing reorientation of Ukrainian society toward Europe. The 2022 Russian invasion, occupation of further Ukrainian territories and mass displacement intensified these trends. While the war is forging the country together, it is experienced in very different ways in its regions, and these collective experiences will matter for postwar Ukrainian politics.
Cardiometabolic risk factors in women experienced thrombosis at a young age
Authors: Movchan Tatiana V. , Vereina Natalia K.
Published: September 2024

Objective: to assess the presence of cardiometabolic risk factors in women who have suffered arterial or venous thrombosis at a young age. Material and methods. The type of study is a "cross-section" based on a prospective observational study. The main group included 49 women aged 18-44 who had undergone instrumental^ verified arterial or venous thrombosis at least 1 year ago. The median follow-up was 80.3 months [50.1; 96.2] months. The control group included 24 practically healthy female volunteers in the same age range. All patients underwent a comprehensive laboratory examination, bioimpedance measurement and oscillographic sphygmography Results. Women with a history of thrombosis had higher levels of LDL cholesterol (3.4±0.8 vs 2.6±0.6 mmol/L); lipoprotein (a) (90.6±7.4 vs56.9±6.5 mg/dl) and adiponectin (10.4±4.3 vs 8.2±3.6 mcg/ml); lower levels of cholesterol HDL(1.5±0.4 vs 1.8±0.4 mmol/l) (0.049>p>0.001). The incidence of visceral obesity in this group was 76.2% vs 37.5% in the control group (p<0.001). The total number of cardiovascular risk factors in these patients averaged 2.7±0.1 vs 1.4±0.2 in the control group (p=0.0001). In the main group, an increase in the cardio-ankle vascular index was revealed 6.85±0.95 vs 6.20±0.51 (p=0.044) in women without thrombosis. Only in the group with thrombosis patients have a decrease in LPK0.9 and an increase in the CAVI index>8 (18,5 vs 0% in the control; p=0.025). Conclusion. Young women with a history of thrombosis are characterized by a more burdened profile of cardiometabolic risk factors, a higher incidence of visceral obesity and increased vascular wall stiffness compared with women without thrombosis of the same age group.
Efficiency of platelet aggregation with different sensitivity of cyclooxygenase to non-steroid anti-inflammatory drugs in patients with nephrolithiasis
Authors: Barinov Edward F. , Giller Dina I. , Akhundova Sabina A. , Yureva Alina S. , Tereshchuk Bogdan P.
Published: September 2024

Objective: to establish the dependence of thrombocyte (Tc) aggregation efficiency on crosstalk-signaling pathways associated with stimulation of TR-receptor and purine P2-receptors, with different cyclooxygenase (COX) activity against the background of non-steroidal anti-inflammatory drugs (NSAIDs) administration in patients with nephrolithiasis (NLT). Material and methods. The study was prospective and included 60 patients with NLT who received non-steroid anti-inflammatory drugs (NSAIDs) for analgesia as part of lithokinetic therapy (LKT). The cohort of patients was divided into two groups, with effective (group 1, n=30) and ineffective (group 2, n=30) COX inhibition. The activity of TP receptors, purine P2 receptors (P2X1 and P2Y receptors) of platelets was assessed on a ChronoLog analyzer (USA). Agonists (ATP, ADP and Arachidonic acid) were used at EC50 and EC10 concentrations. Results. In the 1st group, after 72 hours of LCT, the activity of the TR receptor, P2 receptors of Tc decreased to the level of hyporeacti-vity. The regulation of the compensatory reaction of Tc in response to hematuria was provided through the synergism of the P2 receptors, and the TP receptor and the P2X1 receptor. In 2nd group hyperreactivity of the TP receptor and P2 receptors persisted. Optimal modulation of the compensatory reaction of Tc was provided by the synergism of the TP receptor and P2Y receptors. Conclusion. The efficiency of Tc aggregation during NSAIDs administration is determined by intracellular signalling associated with TR receptor and P2 receptors.
The impact of altruistic leadership on turnover intention amongst healthcare professionals the mediating role of job stress
Authors: Dinler Zeynep Merve , Akbolat Mahmut
Published: September 2024

This study aims to investigate the relationship between altruistic leadership, turnover intention, and work stress in healthcare professionals and to show the mediating role of work stress in the effect of altruistic leadership on turnover intention. Altruistic leadership, turnover intention, and work stress were studied to determine whether healthcare workers differ by occupational group. This study was conducted on healthcare professionals working in a private hospital. The findings indicated that while job stress and intent to leave were high among healthcare workers, altruistic leadership levels were moderate. Additionally, nurses' job stress and intent to leave were significantly higher than those of doctors and other healthcare professionals. The study finds that job stress significantly mediated the relationship between altruistic leadership and intent to leave. The result: Managers who demonstrate altruistic leadership reduce turnover intention to quit their job but have a negative mediation of the model with increased work stress among healthcare workers in situations such as pandemics. As a recommendation, strengthening organisational policies and management practices that support employees and enhancing subordinate-supervisor relationships to support workloads mutually may prove beneficial.
Integrating AI with aviation cybersecurity: The strategic role of human resources
Authors: Mızrak Filiz
Published: September 2024

The escalating complexity of cyber threats in aviation highlights the crucial need to integrate advanced technologies and strategic human resource management. This study delved into incorporating artificial intelligence (AI) in aviation cybersecurity, explicitly focusing on the strategic role of human resources (HR) in supporting these endeavours. Semi-structured interviews with eight industry experts from Turkey were analysed using NVivo to identify critical themes such as HR's involvement in cybersecurity, challenges in AI implementation, and the significance of cultural integration and interdepartmental collaboration. Sentiment analysis with Python's TextBlob indicated high positivity towards AI and strategic HR involvement. The findings underscored the necessity for continuous education, strategic recruitment, and resilient cybersecurity frameworks, emphasising AI's transformative impact on real-time threat detection and predictive analytics. The research offered valuable insights and recommendations for enhancing aviation cybersecurity, highlighting the essential role of HR and the advantages of AI integration.
Bibliometric analysis of career decidedness studies using a visual mapping technique
Authors: Uzunbacak Hasan Hüseyin
Published: September 2024

This study aims to provide an overview of "career decidedness" and identifies related study trends and gaps. Analyzing 104 works published between 1995 and 2024 in the Web of Science (WoS) database using VOSviewer includes 93 journal articles, 12 papers, and two early appearance studies. Most research was in social psychology (88) and management (5). The most cited authors were Lent-Robert (519), Penn, Lee (464), and Ireland Gleen (460), while the most co-cited authors were Lent-Robert (144), Hirschi Andreas (63), and Savickas (63). The USA (1676 citations), Germany (258 citations), and The USA (1676 citations), Germany (258 citations), and Australia (252 citations) were the top cited countries. Leading institutions included the University of Maryland (749 citations), the University of Tennessee (235 citations), and the Leuphana University of Lüneburg (181 citations). Common keywords were career decidedness, self-management model, career decision-making, social career theory, and career development. The top publications were by Duffy (2007), with 203 citations; Lent (2016), with 168 citations; and Lent (2017) with 164 citations.
SPATIAL-SPECTRAL DESCRIPTION OF THE CURRENT DIPOLE AS A SOURCE OF THE MAGNETIC FIELD OF THE HEART
Authors: ГОЛЫШЕВ Н.В. , МОТОРИН С.В. , ГОЛЫШЕВ Д.Н.
Published: September 2024

В реальных условиях экспериментатор работает с входными сверхпроводниковыми преобразователями, конструкция которых в биомагнитных системах зависит от условий исследований, наличия магнитной экранировки, имеющегося криогенного обеспечения, требуемой чувствительности к индукции магнитного поля, технологических возможностей разработчиков. Сравнивать результаты исследований, полученных для разных биомагнитных систем, невозможно. Рассмотрены вопросы описания источника магнитного поля сердца на основе пространственно-частотных преобразований 2D-модели токового диполя. Исследовались: глубина залегания, местоположение и ориентация токового диполя на значение индукции магнитного поля и её спектр по пространству сетки измерения магнитного поля сердца.

In real conditions, the experimenter deals with input superconducting converters, whose design in biomagnetic systems depends on the research conditions, presence of magnetic shielding, available cryogenic support, required sensitivity to magnetic field induction, and technological capabilities of developers. It is impossible to compare the results of studies obtained for different biomagnetic systems. The paper considers the issues of describing the source of the magnetic field of the heart based on the spatial-frequency transformations of the 2-D model of the current dipole. The depth of occurrence, location and orientation of the current dipole on the value of magnetic field induction and its spectrum over the space of the magnetic field measurement grid of the heart are investigated.
NEURAL NETWORK TECHNOLOGIES IN OBJECT DETECTION AND CLASSIFICATION
Authors: БОРЗОВ С.М. , НЕЖЕВЕНКО Е.С.
Published: September 2024

Выполнен обзор основных идей, использованных при решении задач обнаружения и классификации объектов по их изображениям с применением нейросетевых технологий. Рассмотрены ключевые публикации, посвящённые наиболее популярным способам повышения точности классификации. Показано, что в последнее десятилетие нейросетевые методы обнаружения объектов достигли существенных успехов за счёт использования свёрточных технологий и практической реализации идеи глубокого обучения с применением объёмных баз данных. Проанализированы основные недостатки, ограничения и возможные направления развития существующих подходов.

The main ideas used in solving the problems of detecting and classifying objects by their images using neural network technologies are reviewed. The key publications devoted to the most popular ways to improve the accuracy of classification are considered. It is shown that neural network methods of object detection have achieved significant success in the last decade due to the use of convolutional technologies and practical implementation of the idea of deep learning using large visual databases. The main disadvantages, limitations, and possible directions of development of existing approaches are considered and analyzed.
METHODS OF FUNCTIONAL OBSERVER DESIGN FOR NONLINEAR DYNAMIC SYSTEMS
Authors: ЖИРАБОК А.Н. , ЗУЕВ А.В. , ШУМСКИЙ А.Е.
Published: September 2024

Рассматривается задача построения функциональных наблюдателей для динамических систем, описываемых нелинейными дифференциальными уравнениями, которые подвержены внешним возмущениям. Приводятся соотношения, позволяющие построить наблюдатель пониженной размерности, нечувствительный к возмущениям, который оценивает заданную функцию вектора состояния. Теоретические результаты иллюстрируются примером.

The problem of functional observer design for dynamic systems described by nonlinear differential equations under external disturbances is considered. Relations that allow design of the observer of a reduced-order-dimensional invariant with respect to the disturbances and estimating the prescribed function of the state vector are derived. Theoretical results are illustrated by an example.
IMPLEMENTATION OF DISTRIBUTED SIMULATION IN THE MTSS SYSTEM
Authors: РУДОМЕТОВ С.В. , ОКОЛЬНИШНИКОВ В.В. , ЖУРАВЛЕВ С.С.
Published: September 2024

В системе имитационного моделирования MTSS реализована возможность распределённого имитационного моделирования. Для реализации этой возможности применён стандарт HLA. В качестве примера использования распределённого имитационного моделирования представлена федерация, состоящая из двух федератов: имитационной модели очистного забоя угольной шахты и имитационной модели конвейерной сети угольной шахты.

The MTSS simulation system implements the possibility of distributed simulation. To implement this feature, the HLA standard is used. As an example of the use of distributed simulation, a federation consisting of two federates is presented: a simulation model of a coal mine working face and a simulation model of a coal mine conveyor network.