bluuebunny/crossref_metadata_2025 huggingface dataset:
Local anesthetic effect and safety of ropivacaine oily solution
Authors: Lu Wudang , Yao Tong , Hui Minquan , Gu Jingliang , Wu Manli , Zhou Liqiang , Yang Yi , Cao Lei , Cao Yongxiao
Published: January 2024

Purpose: To investigate the effectiveness and safety of ropivacaine oily solution (ROPOS).

Methods: After effecting nerve block in postoperative rats by injection of ROPOS near the sciatic nerve, the expression levels of sodium-potassium-chloride co-transporter 1 (NKCC1) and potassium-chloride co-transporter 2 (KCC 2) in the spinal dorsal horn, were assayed. The safety of ROPOS in beagle dogs was evaluated through subcutaneous injection.

Results: The duration of anesthetic effect of ROPOS was 5 times longer than that of ropivacaine hydrochloride injection. The analgesic effect occurred via downregulation of the expression of NKCC1. Dogs administered ROPOS had acute inflammatory reactions at the injection sites within 3 days, but they recovered after 14 days. No other toxic reactions were observed. The Tmax values for dogs subcutaneously injected with ROPOS at doses of 15, 30 and 60 mg/kg were 2.15 ± 3.09, 6.25 ± 9.62 and 14.85 ± 11.82 h; with the Cmax values of 0.78 ± 0.51, 1.35 ± 0.38 and 2.09 ± 0.53 µg/mL, while the AUC(0-48h) values were 15.88 ± 5.41, 31.46 ± 11.45 and 66.10 ± 17.81 h·µg/mL, respectively. The values of Tmax, Cmax and AUC(0-48h) were positively correlated with ROPOS dose.

Conclusion: Ropivacaine oily solution has a longer duration of local anesthetic effect than ropivacaine hydrochloride injection and it also possesses a good safety profile. The acute inflammatory reactions are noteworthy and will be further investigated in subsequent studies.
Effect of Mongolian medicine alcohol spray therapy on fracture healing in rabbits
Authors: Wu Qilatu A, Rihan , Su Rilige
Published: January 2024

Purpose: To evaluate the healing effect and mechanism of Mongolian medicine alcohol spray therapy on fracture healing process in rabbits.

Methods: Thirty New Zealand white rabbits were randomly divided into normal, fracture, and treatment groups, with 10 rabbits in each group. Fracture and treatment groups underwent bone-fracture modeling, with the latter receiving daily alcohol spraying and stroking for six weeks. Serum calcium and phosphorus were measured using an automatic biochemical analyzer. Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of BMP-2, ALP, and TGF-β. Biomechanical testing was performed to assess callus properties, and real-time polymerase chain reaction (PCR) and western blot were performed to assess BMP-2, Runx2, and p-Smad1/5 expressions in callus.

Results: There were low serum calcium, phosphorus, BMP-2, ALP, and TGF-β levels in fracture and treatment groups, compared to normal group. Similarly, treatment group showed significantly increased levels of serum calcium, phosphorus, bone morphogenetic protein 2 (BMP-2), alkaline phosphatase (ALP), and transforming growth factor-β (TGF-β) (p < 0.05) compared to fracture group. Biomechanical testing revealed that maximum load, stiffness, and deflection of callus in the fracture and treatment groups were significantly lower compared to normal group (p < 0.05). expressions of BMP-2, Runx2, and p-Smad1/5 mRNA in the callus significantly decreased in both fracture and treatment groups compared to normal group (p < 0.05). However, treatment group showed significantly increased expression levels compared to fracture group (p < 0.05).

Conclusion: Mongolian medicine alcohol spray therapy promotes fracture healing in rabbits and increases maximum load of the callus, possibly through upregulation of the BMP-2 signaling pathway. Further research is necessary to confirm the exact mechanism by which alcohol spray therapy regulates BMP-2 signaling pathway.
PELATIHAN DASAR AKUNTANSI PEMILIK UMKM DI KABUPATEN BANGKA TENGAH
Authors: Sumiyati Sumiyati , Fahria Izma , Khairiyansyah Khairiyansyah , Aprilian Rahil
Published: January 2024

MSME owners in Central Bangka also have not been able to prepare financial reports in accordance with applicable financial standards. This is because MSME owners do not know the basics of accounting records. Even though there are quite a lot of Android-based accounting and financial reporting applications available with various choices according to the needs of the owner. This service uses the lecture method to introduce the basics of accounting and demonstration methods for assisting in the preparation of Android-based financial reports. This activity is expected to provide knowledge for PPKL and MSME owners regarding the basics of accounting and at the same time prepare financial reports for MSME owners. Evaluation of this activity is carried out by providing feedback sheets in the form of pre-test and post-test to measure the level of understanding of participants.
Voluntary intake and digestibility of lambs fed hay of forage soybeans cv. ‘Rongai’ [Lablab purpureus (L.) Sweet]
Authors: Valencia Elide , Rivera Francisco
Published: January 2024

Sun cured hays of two legumes, forage soybean (Glycine max L. Merr.) cv. ‘Hinson Long Juvenile’ and Lablab [Lablab purpureus (L.) Sweet] cv. ‘Rongai’, were compared in terms of voluntary intake and digestibility of dry matter (DM), crude protein, and neutral detergent fiber, in six individually caged lambs (28.4 ± 4 kg body weight). Treatments were arranged in a completely randomized design with three replicates (animals). The lambs were fed periodically during a seven-day adaptation period, and data collection was carried out over five days. ‘Hinson’ and ‘Rongai’ did not differ in crude protein (15.8 vs. 15.5%) and neutral detergent fiber (56.2 vs. 55.1% of DM). Lambs fed cv. ‘Hinson’ consumed more DM (P<0.05) than those fed ‘Rongai’ (945 vs. 853 g/d). ‘Hinson’ also registered higher DM digestibility (56.2 vs. 49.6%) than ‘Rongai’. Based on their agronomic characteristics, chemical composition, voluntary intake, and digestibility, both legumes exhibit good potential for use as hay. Large-scale planting of these legumes could supply hay for ruminant feeding to supplement low quality tropical grasses and reduce the need for imported protein sources for ruminant feeding.
EVALUATION OF VISUAL ASSESSMENT AS A TOOL FOR CLASSIFYING HAIR COAT TYPE IN PUERTO RICAN SLICK AND WILD TYPE-HAIRED HOLSTEIN COWS
Authors: Sánchez-Rodríguez Héctor L. , Domínguez-Anchondo Carolina L. , Muñiz-Ruiz Anthony K. , Tosado-Martínez Tatiana , Contreras-Correa Zully , Domenech-Pérez Katherine , Muñiz-Colón Gladycia C.
Published: January 2024

EVALUATION OF VISUAL ASSESSMENT AS A TOOL FOR CLASSIFYING HAIR COAT TYPE IN PUERTO RICAN SLICK AND WILD TYPE-HAIRED HOLSTEIN COWS
La construcción de la identidad gráfica de las instituciones públicas de Galicia en la posmodernidad (1979-1999): la reinterpretación de los símbolos propios a partir de los mitos-de-lugar
Authors: Dopico Castro Marcos , Vázquez Gómez Jesús , Rico López Cibrán
Published: January 2024

La llegada de la democracia a España supuso la descentralización del Estado y una oportunidad para repensar una compleja identidad cuyas diferentes sensibilidades nacionales habían sido cercenadas y perseguidas durante la dictadura. El diseño emergió como una herramienta de vanguardia, y la identidad visual de los nuevos estamentos políticos; ministerios, autonomías, diputaciones, ayuntamientos y demás entidades territoriales abordaron una urgente renovación de su imagen con resultados dispares. En Galicia, la primera generación de diseñadores y diseñadoras con conciencia de serlo, protagonizaron una búsqueda de novedosos símbolos identitarios.  
 
Siguiendo las nuevas ideas posmodernas, reinterpretaron la tradición desde la esquina atlántica en contraposición al concepto de «mediterraneidad» dominante. Recurrieron a los símbolos ancestrales como la vieira del peregrino, la Cruz de Santiago, los símbolos de la cultura castrexa o las reinterpretaciones de heráldica con la complicidad política de instituciones que buscaban una identidad singular y un encaje propio. Los estudios de diseño construyen sobre las ideas de sus predecesores, aquellos diseñadores-artistas que habían intentado el proyecto casi utópico de los años sesenta y setenta del Laboratorio de Formas de Galicia. El diseño gráfico en la Galicia de los ochenta y noventa se movió entre la contradicción de descubrir, al mismo tiempo, el rigor del proyecto moderno y los nuevos postulados posmodernos. Este artículo pretende analizar las singularidades del diseño corporativo institucional y territorial en Galicia en la época posmoderna, mediante la reinterpretación de una serie de símbolos propios como mitos-de-lugar que han definido hasta la actualidad una identidad gráfica diferenciada.
Análisis financiero, la clave para la toma de decisiones
Authors: Valenzuela Chicaiza Carmen Verónica , Ushiña Gualpa Juan Elias , Paredes Moyano Jorge Enrique , Carvajal Lita Mariana De Jesús
Published: January 2024

El libro Análisis Financiero, La Clave para la Toma de Decisiones, aborda una amplia gama de temas relacionados con el análisis financiero con el objetivo de proporcionar a los estudiantes y lectores en general la base y sustento para la toma de decisiones financieras estratégicas, se realiza una introducción al análisis financiero, reconocimiento de los estados financieros y su función en el análisis financiero, conceptos y utilidad, objetivos, estados financieros porcentuales e integrales, cálculo de razones financieras, análisis de indicadores de mercado, punto de equilibrio financiero y operativo, apalancamiento, estados financieros proyectados, entre otros. El libro está escrito de forma clara y concisa, y proporciona ejemplos prácticos para ilustrar los conceptos y técnicas de análisis financiero. Está dirigido a estudiantes, profesionales y cualquier persona que desee aprender sobre análisis financiero.
How to Build a Stock Exchange
Authors: Roscoe Philip
Published: January 2024

Exploring the development of stock exchanges, markets and the links with states, in this book Roscoe offers a cautionary tale about the drive of financial markets towards expropriation, capture and exclusion and wonders what the future for finance might be, and how we might get there.
PRAVNI POLOŽAJ VOJNIH SVEŠTENIKA I VERSKIH SLUŽBENIKA U VOJSCI SRBIJE
Authors: Karapandzin Stevica S.
Published: January 2024

on the Constitution of the Republic of Serbia and five laws, as well as a number of by-laws, the paper analyzes the legal position of military priests, i.e. religious officers in the Serbian Army. A part of the domestic new-century legal and by-law regulations was presented, which regulated the issue of religious service, as well as the characteristics of the legal position of military priests in modern armies. By combining content analysis, deduction and historical method, the paper presents a part of the research that leads to the conclusion of the necessity of ensuring the right to freedom of religion to a specific category of citizens in a specific way, and exclusively while performing tasks from functional competence.
MODELI FINANSIRANjA VERSKIH ORGANIZACIJA U EVROPI: REGULATIVA I PRAKSA
Authors: Milović Nikifor
Published: January 2024

This paper discusses the complex topic of financing religious organizations in Europe. While there is a great deal of diversity in the ways in which religious organizations are funded, most countries have a system that allows for funding from public resources, subject to certain conditions and limitations. The legal regulations that apply in different countries also vary, but in most cases, they aim to ensure transparency and accountability in the financing of religious organizations. The relationship between the state and the church in Europe is also very complex and varies from country to country, but in most cases, it is based on mutual respect and cooperation. Overall, this document provides useful information on the financing of religious organizations in Europe and can be of benefit to anyone interested in this topic
Impact of Influencer Trustworthiness and Financial Literacy on Herding Behavior with Risk Perception Mediating Variables of Indonesian Millennial Investors
Authors: Natahadi Herdyawan , Makaryanawati Makaryanawati , Keliwon Kamarul Baraini
Published: January 2024

The ease of investment resulted in soaring number of millennial investors in Indonesia. Most investors in Indonesia are a beginner and do not know how to invest properly. Ignorance of investment encourages investors to find information and looking for role model then commonly leads to herding behaviour. This habit contradicts with traditional finance theory where investors supposed to invest rationally and avoid risk. This study will further explore the relationship between trustworthiness of financial influencers and financial literacy on herding behaviours with risk perception as mediating variables in millennial investors in Indonesia. Based on path analysis resulting the variable significantly influence each other directly or indirectly through mediating variable. Direct effect of trustworthiness financial influencer positively related with the herding behaviour, but the financial literacy negatively related with the herding behaviour. Indirectly Financial literacy level increased to increase risk perception and trustworthiness financial influencer vice versa. The decrease of risk perception leads millennial investor to herd and the increase of risk perception make investor more careful to make investment. There are still 33% of other factors influenced outside this study, for example gender, age, income, occupation and many other. Prior study has not examined the impact of a millennial follower’s trust on influencers to herding behaviours using risk perception as a mediating variable.
PROSPECTS AND CHALLENGES OF EDUCATING A DEAF-BLIND STUDENT IN A UNIVERSITY IN GHANA
Authors: Dogbe Daniel S. Q. , Anku Francis Kwame
Published: January 2024

This study explored the challenges and prospects of educating a deaf-blind student in a public university in Ghana. The study utilised an exploratory qualitative research design based on interviews and observation to explore how the deaf-blind learner navigated university life. The study found that the challenges experienced by all stakeholders included a lack of knowledge and understanding about deaf-blindness, communication challenges, inadequate preparation of educators/teachers and resource persons, lack of support structures for all stakeholders, and the time-consuming nature needed to educate the deaf-blind learner. The study recommends continuous in-service training on basic knowledge of deaf-blindness, instructional and socially inclusive strategies, and communication modes for deaf-blind learners for all stakeholders. A collaborative team approach to delivering training and inclusive education that involves all stakeholders is necessary. The study concludes that if lecturers of learners who are deaf-blind are provided with the necessary training on the skills and knowledge of facilitating communication with their students, this would, in turn, contribute positively towards teaching and learning.
 

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ENHANCING THE QUALITY OF GENERAL PHYSICS EDUCATION THROUGH PROJECT-BASED LEARNING: A STUDY AT THE UNIVERSITY OF INFORMATION TECHNOLOGY AND COMMUNICATIONS
Authors: Huong Duong Thi Thu
Published: January 2024

The article explores the impact of Project-Based Learning (PBL) on General Physics education. The study, conducted with 120 students at a Vietnamese university, utilizes a mixed-method approach combining theoretical research, expert opinions, and data analysis. It examines the shift from traditional teaching to PBL, emphasizing hands-on, real-world problem-solving to improve understanding and application of physics concepts. The findings indicate significant positive outcomes in student engagement, understanding, and satisfaction. The study also discusses the challenges and considerations in implementing PBL, the importance of teacher training, and the potential for scalability and long-term impact in diverse educational settings.
 

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EQUIVALENCE OF PARABOLA΄S DEFINITIONS WITHIN MATHEMATICAL MACHINES SIMULATED BY “GEOGEBRA”
Authors: Ntontos Georgios K. , Koleza Eugenia
Published: January 2024

This paper aims to highlight two historical parabolographs and a third one that is at the design level and to prove the equivalence of the respective definitions of parabola they contain. Specifically, using the Geogebra math software, each mechanism is attempted to articulate another, so that by moving the cursor of the original mechanism to the common output of the two articulated mechanisms, the same parabola is drawn. This proves the equivalence of definitions of parabolic curve as well as of suitably articulated mathematical machines.
 

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Digitalisasi Dakwah Berbasis Kearifan Lokal
Authors: Nirwan Wahyudi AR  , M. Said Nurhidayat , Fitra Siagian Haidir
Published: January 2024

Penggunaan teknologi digital untuk menyebarkan pesan-pesan dakwah dengan tetap mengapresiasi kearifan lokal masyarakat setempat adalah langkah dalam proses digitalisasi dakwah yang sangat penting, terutama di Indonesia yang memiliki keragaman budaya, suku, dan agama. Penting untuk memasukkan kearifan lokal sebagai dasar nilai dan pesan dalam upaya digitalisasi dakwah. Melalui artikel ini, penulis mendeskripsikan digitalisasi dakwah berbasis kearifan lokal masyarakat Indonesia melalui pendekatan riset etnografi virtual. Pemanfaatan teknologi digital secara bijak dapat berdampak signifikan terhadap penyebaran pesan-pesan keagamaan dan menjaga kearifan lokal di tengah dinamika modernisasi dan globalisasi. Digitalisasi dakwah yang mengintegrasikan nilai-nilai lokal turut membantu pelestarian budaya, mencapai sasaran dakwah yang lebih luas, mengadaptasikan dakwah dengan perkembangan zaman, memperkaya konten dakwah, serta memperkuat identitas agama dan bangsa. Adapun bentuk pelaksanaannya dapat bervariasi, tergantung pada preferensi setiap dai. Namun, secara umum dan praktis, digitalisasi dakwah berdasarkan kearifan lokal di Indonesia dapat diwujudkan melalui platform digital seperti media sosial, situs web, dan aplikasi mobile.
Proses Mandi Tujuh Bulanan Tradisi Masyarakat Banjar Di Kelurahan Selat Utara Kecamatan Selat Kabupaten Kapuas
Authors: Almira Riski Amanda, Fimeir Liadi, Muhammad Husni
Published: January 2024

Tradisi Mandi Tujuh Bulanan hingga saat ini masih tetap dilaksanakan dan berlaku bagi setiap wanita yang hamil anak pertama. Secara umum makna dari prosesi mandi tujuh bulan ini bermakna adalah agar dalam proses melahirkan nanti dapat berjalan dengan lancar dan selamat hal ini terlihat dari beberapa rangkaian proses yang dilakukan. Tradisi mandi 7 bulanan merupakan adat kebiasaan yang dilakukan secara turun temurun oleh masyarakat banjar khususnya ibu yang hamil anak pertama pada usia kandungan memasuki 7 bulan. Upacara 7 bulanan adalah sebagai bentuk syukur kepada allah karean sebentar lagi bayi yang di kandung akan lahir ke dunia. Upacara ini di harapakan bisa menjadi doa untuk anak yang di kandung agar selalu taat kepada allah dan bisa bebakti kepada kedua orang tuanya. Ketika upacara di gelar, si ibu yang akan di mandikan berada pada dalam pagar mayang untuk di mandikan. Setelah selesai mandi 7 bulanan  si ibu yang hamil tersebut rambutnya di sisir, di rias,  dan di beri pakaian yang bagus. Upacara ini di akhiri dengan bersalaman sambil mendoakan kepada si ibu yang mandi tersebut. Penelitian ini menunjukan bahwa tradisi yang turun temurun tetap bertahan di tengah masyarakat, meskipun gempuran budaya modernisasi dan globalisasi budaya  dengan dahsyat menerpa, hal ini disebabkan budaya Tradisional seperti mandi Tujuh Bulanan menjadi salah satu keyakinan yang diyakini oleh masyarakat secara kuat dan memberikan efek manfaat bagi masyarakat itu sendiri .
Akreditasi Perguruan Tinggi Di Era Society 5.0: Tantangan dan Solusi
Authors: Septian Aristya  , Muchammad Eka Mahmud
Published: January 2024

Artikel ini membahas peran kunci akreditasi perguruan tinggi dalam menghadapi era Society 5.0, di mana perubahan teknologi dan kompleksitas masyarakat menciptakan tantangan baru. Melalui metode studi pustaka, penelitian ini mengeksplorasi bagaimana akreditasi dapat disesuaikan dengan dinamika era baru, memastikan kualitas dan relevansi pendidikan tinggi. Penerapan akreditasi menjadi penting sebagai solusi dalam mempersiapkan mahasiswa menghadapi ketidakpastian dan perubahan yang cepat di era Society 5.0. Artikel ini menyoroti dampak akreditasi dalam menjaga standar kualitas, mendorong inovasi kurikulum, memberikan manfaat berkelanjutan, dan memberikan jaminan kepada mahasiswa dan masyarakat. Kesimpulannya, akreditasi memainkan peran krusial dalam memastikan perguruan tinggi tetap adaptif, relevan, dan berkualitas di tengah transformasi masyarakat dan teknologi.
Otolith morphology and total length relationships in Schizothorax grahami
Authors: Zhou Yang , Cui Weijie , He Zhongtang , Xu Li , Yang Feng , Lu Qun , Liu Jianhu , He Tao
Published: January 2024

Otolith is important for studying fish populations and life histories. In this study, the dominant species of Schizothorax grahami in the source section of the Chishui River was taken to understand the relationships between otolith morphology and total length (TL). Results showed a large difference between the four TL groups (A/B/C/D), except group B is similar to group C. The combined discrimination success rate of linear discriminant analysis was 62.2%. Group A and D’s success rate is the highest, at around 75%. Meanwhile, the success rate for Group B and Group C is below 65%. The one-way ANOVA of the Shape Index and the Canonical analysis of Principal Coordinates with two coefficients (Fourier coefficients and Wavelet coefficients) showed that Group B is similar to Group C, with a large difference from the other two groups. When TL was greater than 100 mm (the pearl organs appearing), the otolith growth was lower changing. Otolith morphology still changes with growth after sexual maturity in fish, so the larger fish is more useful for conducting otolith morphology studies for accurate evaluation and management of local fishery resources.
Role of Ayurveda in Postponing Arthroplasty in Severe Degenerative Joint Diseases
Authors: Swathi Padinjakkara  , Bindu.P.R
Published: January 2024

Degenerative joint disease, also known as osteoarthritis (OA) is a common “wear and tear” disease. Typically, relentless repetitive motion deteriorates structural joints and causes inflammation is the underlying cause of this illness. Although it may affect any joint, it is usually seen in the hands, hips, knees, and spine. Bilateral hip osteoarthritis is described as a non-inflammatory degenerative condition of the hip joint that typically manifests in middle or late life. It is marked by acetabular dysplasia and growth or maturational abnormalities in the femoral neck and head. Pain experienced while moving or carrying weight is a prevalent symptom. As per Ayurvedic classics, the clinical presentation can be understood as Sandhigatavata in the initial stages and later as Asthigathavatha. Initial presentation includes difficulty in moving joints. Bony pain and joint discomfort are explained as Sakthi and Sandhi Shoolam and associated with Theevram balakshayam [severe weakness]. Internal and external applications of Sneha are the main therapeutic modalities explained in Asthi-majja gatha vatha chikitsa by Bruhathrayees. In Charaka samhitha, Ksheera, Basthi and Sarpi with Thiktha rasa Dravya are mentioned as the primary treatment along with Panchakarmas. Because it is the best of the four Snehas, cow's ghee was chosen for the study. According to Sanskaranuvartana, Ghrita has the ability to change in order to absorb the properties of things that are introduced while retaining its original attributes. Ghee's inherent property, oleate, settles Vata and Pitta while without raising Kapha. Phospholipid bilayers are the core elements of cell membranes. Molecules and ions are unable to directly get into or out of the cell via the lipid layer. We constantly need a lipid medium to go deeper. Asthi, Majja, and Sukra have been considered as deeper Dhatus in Ayurveda. The greatest administration for that is Samana accha snehapana. Degenerative joint condition can be effectively treated with traditional Asthigathavata Chikitsa.
An Ayurvedic Approach in the Management of Vatarakta
Authors: Swadha Tiwari  , Anupam Biswas  , Shomya Tiwari  , Tapas Bhaduri
Published: January 2024

Ayurveda, since beginning emphasizes on the importance of wholesome lifestyle for maintenance of health and prevention of several diseases. Changing dietary habit with fast food culture, lack of physical activities and stressful environmental factors are the leading cause of many lifestyle disorders and Vatarakta is one of them. It is characterized by severe pain, swelling, stiffness, inflammation and burning sensation of affected joints. It may be correlated with Gout in contemporary science. A 45 years old female patient visited Panchakarma OPD of S.V.S.P hospital with severe pain, mild oedema, tingling sensation in the joints of hand and leg bilaterally associated with burning sensation and discolouration of both feet since 3 month. She was treated with Shamana aushadhi, Panchakarma therapy and specific dietary intervention for 30 days. Encouraging improvement in both subjective and objective criteria was obtained. This case study may ignite a positive hope for individual suffering from Vatarakta.
Immune-Enhancing Effect of an Ayurveda formulation Vidhara-Amalaki Yog
Authors: Minakshi Paneru  , Nisha Ojha
Published: January 2024

Plant extracts and Ayurvedic polyherbal mixtures have been used to treat a variety of diseases since time immemorial. Studies on the therapeutic effects of these extracts in the treatment of various disorders are also extensively established. The synergistic effect of polyherbal medications in repairing and revitalizing the immune system is also highlighted in Ayurvedic classics. Argyreia speciosa Linn. (Elephant Creeper, Vidhara in Sanskrit; Family: Convolvulaceae) and Emblica officinalis Gaertn (Indian gooseberry, Amalaki in Sanskrit; Family: Phyllanthaceae) are important drugs explained in Ayurvedic literatures and Nighantus for their Rasayana and Bala-vardhaka properties (immunomodulatory actions). They also possess the restorative and rejuvenating powers as they act on the immune system and positively affect the response of the body towards disease causing pathogens. In this review a comprehensive account of the pharmacological activities along with the immunomodulatory activities of Vidhara- Amalaki yog (compound formulation of Vidhara and Amalaki) are included in view of the many recent findings of importance on this plant.
In-Vitro Experimental Study on the Anticoagulant Activity of Rakta Pravarthana Churna
Authors: B S Kasturirangan  , Angadi Ravindra  , B N Ashok Kumar  , R R Geethesh
Published: January 2024

Coagulation disorders disrupt the delicate balance between clot formation and prevention. Various coagulopathies involve abnormal clotting as a manifestation. Rakta Pravarthana Churna (RPC) is an Ayurvedic formulation designed for external application during Rakta Mokshana to address Apravarthana or clotting tendencies. Aims & Objectives: The in-vitro study aims to evaluate its anticoagulant (thrombolytic) activity using blood samples from healthy human volunteers. Materials & Methods: The clot lysis activity of aqueous and alcohol extracts of Rakta Pravarthana churna at two different concentrations (5% & 20%) along with streptokinase as a positive control and distilled water and alcohol as a negative control was carried out. Results: The aqueous extracts showed clot lysis activity whereas alcoholic extracts did not exhibit evidently significant clot lysis. Discussion: In comparison with positive control (streptokinase), aqueous extract of RPC at 5% concentration showed 10.76% more clot lysis activity, aqueous extract of RPC at 20% concentration showed 14.31% more activity. Conclusion: Aqueous extracts of RPC promote clot dissolution, while alcoholic extracts displayed inhibitory effects. These findings show the complexity of Ayurvedic drug interactions with coagulation processes. The study contributes to the understanding of anticoagulation potential of RPC and its scope for potential therapeutic applications.
Etiopathogenesis of Vibandha w.s.r to Functional Constipation in Children
Authors: Pooja Bhat  , Nagaratna S Jartarghar  , Chithralekha
Published: January 2024

Vibandha/Baddapureesha means Sanga or obstruction for the passage of stool, and this condition can be due to the functional or structural. Vibandha (constipation) has been described in numerous places. In conditions like Udavarta, it manifests as a separate entity, and in diseases like Kasa and Shwasa, it plays a significant role in the occurrence of Samprapti. Vibandha as a separate entity has not been described by any major text in Ayurveda. Its Lakshana includes voiding of small quantity of stool with difficulty or voiding a large quantity of watery stool with sound and pain. Current era due to lifestyle, fast and stressful life, humans are frequently led towards irregular and bad habits of Ahara, Vihara and Vegadharana leading to several problems like Vibandha, Ajirna, Sthoulya etc. Vibandha not only caused because Pureeshavahasrotho Dusti it can also be caused because of Apanavata Vaigunya along with Agnimandya. As Agni is responsible for the formation of Pakwa Mala, Agnimandya is considered as main cause for Vibandha. Hence Agni plays a significant role in Vibandha.
Adverse events following immunization among children during primary immunizations in selected health facility of Himachal Pradesh
Authors: Sharma Neeti , Pugazhendi Sanchita , Semwal Jayanti , Prakash Kamli
Published: January 2024

Background: Vaccine related problems are commonly reported after immunizations and are a matter of concern for health care professionals. A study on the pattern and rate of incidences of vaccine related problems was conducted among children undergoing primary immunizations. Materials and methods: The study was conducted in Zonal hospital, Solan, Himachal Pradesh. 150 mothers and their children undergoing immunization were enrolled in the study using systematic random sampling and followed on every immunization event until nine months. Vaccine related problems were enquired at every immunization events namely birth, six weeks, ten weeks, fourteen weeks and nine months using a self-structured tool to assess vaccine related problems among children. Results: Pain at vaccination site, redness and swelling, excessive crying, fever, and sleep related problems, feeding problems and fever were common AEFIs reported by mothers among children. Conclusion:  AEFIs are frequent and need to be reported. None of the child had any severe reaction or hospitalization after immunization.
Integrating diversity into the medical curriculum
Authors: Shrivastava Saurabh R , Shrivastava Prateek S , Joshi Ahishek
Published: January 2024

In the field of medical education, diversity refers to the presence and representation of persons from a diversified range of personal backgrounds, experiences, and characteristics across the student community, faculty members, and employees in the institution. The scope of diversity in medical education is immense and it plays a vital role in creating an effective learning environment. Once students are exposed to a group of diverse students and patients during their undergraduate training, there is a significant improvement in cultural competence, which becomes crucial in our mission to deliver patient-centered care. Considering the merits of diversity in the medical curriculum for medical students, there is an indispensable need to take specific measures to ensure that diversity is integrated in the curriculum, as it will also ensure the delivery of equitable and culturally competent medical care. As important is to ensure the integration of diversity into medical curriculum, equal importance has to be given to the measurement of various initiatives that have been taken to promote diversity in medical education. In conclusion, diversity in medical education is the need of the hour to create a fruitful learning environment for medical students. This calls for the need to take measures for the integration of diversity into the medical curriculum and subsequently identify strategies and indicators to measure and monitor the progress of diversity initiatives in medical institutions.
A systematic review of the role of surfactants in bronchial asthma: Implications for pathogenesis and treatment of the disease
Authors:   Pathology, Basic and Clinical Pharmaco State University, Osh, Kyrgyzstan, Ismailov Imetkul
Published: January 2024

The study aims to examine existing literature and highlight the significance of surfactants as a factor in pathogenesis and a potential therapeutic target in bronchial asthma. A systematic search is conducted in Scopus, Web of Science, and PubMed/Medline, utilizing specific keywords related to surfactants and bronchial asthma. The findings demonstrate that surfactants, a unique mixture of lipids and proteins, play a crucial role in the mechanisms of innate and adaptive immunity in the lungs. They act as a mechanical barrier, modulate inflammatory responses, and interact with pathogens. Changes in surfactant composition and levels have been associated with various lung diseases, including bronchial asthma
PERBANDINGAN PERATURAN TINDAK PIDANA KEKERASAN SEKSUAL TERHADAP ANAK DI INDONESIA DAN THAILAND
Authors: Abunawas Abunawas , Aprilsesa Tri Dian , Aminah Siti , Tahir Muhammad , Marnita Marnita
Published: January 2024

Anak berperan dalam menjamin stabilitas masa depan bangsa dan negara, sehingga memerlukan perlindungan dan perawatan khusus untuk memastikan tumbuh kembang generasi masa depan bangsa dan negara. Kasus kekerasan seksual terhadap anak menimbulkan permasalahan bagi berbagai negara salah satunya Indonesia dan Thailand Tujuan penulisan makalah penelitian ini adalah untuk menemukan persamaan dan perbedaan dokumen hukum di Indonesia dan Thailand melalui studi banding. Metode penelitian yang digunakan adalah penelitian hukum normatif yang tersistematis terhadap subjek perbandingan hukum dan dokumen hukum. Data yang digunakan dalam penelitian ini adalah data kualitatif sekunder yang diperoleh dari tinjauan pustaka. Temuan studi perbandingan ini fokus pada isi dan dampak dari hukum pidana masing-masing negara terhadap kekerasan seksual anak secara normatif dan penegakan hukum. Antara KUHP Indonesia dan KUHP Thailand sama-sama mengatur tentang tindak pidana pelecehan seksual terhadap anak. Sementara itu, perbedaan lain antara aspek hukum kriminalisasi kekerasan seksual di Indonesia dan Thailand adalah dampak sanksi pidana yang dijatuhkan kepada pelakunya.
El desvío Retórico de la crítica en Walter Benjamin
Authors: García Elizondo Eduardo
Published: January 2024

El presente trabajo se propone analizar el giro retórico que hace Walter Benjamin en su lectura de la crítica kantiana a la metafísica. En función de ello, mediante una vía de interpretación expositiva, abordaremos cómo se sitúa lo retórico en el marco de una tarea crítica que busca ampliar los dominios transcriptos de la experiencia posible hacia un trasfondo incondicionado, no reducible bajo el ideal sistemático de la Wissenschaft y sus primados de tipo metafísico-gnoseológico. A partir de la exposición de los vínculos entre crítica retórica, Sprache y el uso retórico de figuras teológicas en algunos contextos discursivos de las disquisiciones benjaminianas, arribaremos a las consideraciones finales, en las que planteamos que el giro retórico de la crítica efectuado por el autor resulta inseparable de una crítica radical al estatuto del discurso filosófico sistemático y a su fundamento de determinación idealista, concebida mediante una reinvención de categorías y problemas estéticos.
Evaluation of Phytochemical and Antioxidant Potential of Lepidagathis Pungens Nees: A Therapeutic Application
Authors: R Jothi Lakshmi , R Srinivasan
Published: January 2024

ANTIOXIDANT POTENTIAL AND PHYTOCHEMICAL PROFILING OF LEPIDAGATHIS PUNGENS NEES: A COMPREHENSIVE ANALYSIS FOR THERAPEUTIC APPLICATIONS

 

Abstract:

                          This study aimed to investigate the physicochemical properties, heavy metal content, inorganic elements, extract parameters, and antioxidant activities of Lepidagathis pungens Nees, a plant with potential health-promoting properties. The physicochemical analysis revealed the presence of ash values, moisture content, total fiber content, swelling index, and foaming index. Heavy metal content analysis showed that cadmium, nickel, mercury, lead, chromium, and arsenic levels were within the safe limits set by the World Health Organization, indicating the plant's safety for consumption. The presence of various essential inorganic elements such as calcium, chloride, copper, iron, magnesium, nitrate, phosphate, and potassium was also confirmed. Five different solvent extracts, including Oil ether, chloroform, ethyl acetate, methanol, and absolute ethanol extracts of the plant were obtained. from the whole plant, and their extractive values, colors, odors, and consistencies A determination was made. The methanol and aqueous extracts had the highest extractive values. The fluorescent analysis of the whole plant powder revealed various colors under daylight, long UV, and short UV light, depending on the solvent used. The antioxidant properties of the Lepidagathis pungens Nees extracts were assessed through their product scavenges superoxide radicals, hydroxyl radicals, and lipid peroxidations. An aqueous and methanol extract demonstrated the highest scavenging activities across all concentrations for both Lipid peroxidation and hydroxyl radicals. The scavenging activity increased in an inverse relationship between dose and response. In conclusion, this study demonstrated the potential of Lepidagathis pungens Nees as a source of antioxidant compounds, particularly in methanol and aqueous extracts. The safety profile and presence of essential inorganic elements in the plant suggest its potential for use in traditional medicine or as a dietary supplement. Further research into the Inhibitors of antioxidant activity: specific compounds could lead to the development of health-promoting products or therapeutic interventions utilizing the extracts' antioxidant properties.
A comparative clinical study on Matra Basti with Kshirabala Taila and Ketakadya Taila in Janu Sandhigata Vata
Authors: Sabharwal Yamini , D Ratnang , Parappagoudra Mahesh , Gayakwad Anjali , Dash Gaurav Kumar
Published: January 2024

Osteoarthritis is a prevailing form of Arthritis, also known as Degenerative Joint Disease, which occurs due to the gradual deterioration of joints, including the articular cartilage and subchondral bone. Common symptoms of osteoarthritis include joint pain, stiffness, and reduced range of motion, leading to a loss of flexibility in the affected joints. In modern medical science, NSAIDs are commonly prescribed to manage the symptoms of Osteoarthritis which help in reducing pain, inflammation, and stiffness. NSAIDs only provide symptomatic relief to the patients. Indeed, Sandhigatavata and Osteoarthritis are closely correlated terms, with Sandhigatavata being the Ayurvedic term for Osteoarthritis. Ayurvedic texts suggest various treatments for this condition, with the most common ones being repeated application of Snehana and Swedana, along with Basti and Mriduvirechana. Among these treatments, Basti is considered a crucial part of the overall therapy, and the Matra Basti, a specific form of Basti, is relatively easier to administer without any complications. Here an attempt was made through Matra Basti with Kshira Bala Taila and Ketakadya Taila mentioned in Vata Vyadhi Chikitsa specifically. This is an open-label, observational, and clinical research study, a total of 30 patients diagnosed with Sandhigata Vata were randomly selected from the OPD and IPD of Parul Ayurved Hospital and Khemdas Ayurved Hospital in Waghodia, Vadodara. These patients were divided into two groups i.e., in Group A, 15 patients were given Abhyanga, Baspa Swedana followed by Matra Basti with Kshira Bala Taila, and in Group B, 15 patients were given Abhyanga, Baspa Swedana followed by Matra Basti with Ketakadya Taila for 15 days. The assessment of patients was carried out before treatment, on the 8th day, after treatment, and on the 30th day of treatment. Statistically significant effects were seen in both the groups in symptoms including Sandhi Shoola, Akunchan Prasaranajanya Vedana, Sparsha Asahatva, Sandhi Sphootana, and ROM.
Physicochemical and preliminary phytochemical analysis of different brands of Hingwashtak churna; a polyherbal medicine in Sri Lanka
Authors: Dassanayaka Gathika Ganganath , Srikokulan Sivasinthujah , Christy Jeyaseelan Tharmila
Published: January 2024

Hingwashtak churna is a polyherbal medicine, used to treat gastrointestinal diseases like gastric ulcers, bloating, acidity, and joint disease. The quality evaluation of hingwashtak churna is needed for its acceptability and safety for stakeholders. Therefore, this study focused on the evaluation of physiochemical and preliminary phytochemicals of different selected marketed brands of polyherbal medicine “hingwashtak churna” in Kurunegala, Sri Lanka. Three brands of powder form (H1, H2 & H3) of Hingwashtak churna samples were purchased in Kurunegala, Sri Lanka. Preliminary phytochemical screening and physio-chemical tests were carried out for each brand. The results were analyzed with one-way ANOVAs using SPSS 22. The results of physico-chemical parameters obtained from the study showed that there was a significant difference (Ρ > 0.05) among all three marketed brands as well as between each and other brands. Phytochemical screening of aqueous extract revealed the presence of carbohydrates, reducing sugar, flavonoids, saponins, tannins, steroids, phenols and ascorbic acid in all the brands. There was a significant difference in the flow properties of the powders from all three brands. Most of the parameters of the physiochemical tested brands of Hingwashtak Churna had roughly similar values to previous studies. As no published data are available in Sri Lanka, this preliminary profile could be a reference in future studies. However, further analysis has to be done in order to standardize the product according to the WHO guideline on Quality control methods for medicinal plant materials.
Development and Evaluation of Lavangadi Vati in the Form of Suspension- A Polyherbal Novel Liquid Dosage Form
Authors: Swaminath Meenu , R S Hiremath , V S Mannur
Published: January 2024

Introduction: The demand of the herbal medicine is increasing worldwide due to its lesser toxicity and side effects. Though so many formulations are there in ayurveda, the patient compliance for its palatability and acceptability need to consider. The present study focused on the modification of lavangadi vati into suspension, a liquid dosage form, which is effective in prana vaha sroto vikaras (disorders related to respiratory system) and standardising its quality parameters. Aims: To develop lavangadi vati suspension from the classical lavangadi vati dosage form and standardising the process by the evaluation of the micrometric properties, quality control parameters and TLC finger printing. Materials and Method: Among the six trials, the suspension containing lavangadi vati churna in a dose of 1gm/5ml and 4% sodium CMC as the suspending agent with a specific formula and using suitable excipients were selected as master formula. Result: As per the criteria lavangadi vati shown with particle size of 433.7nm, Haussner ratio with 1.06, Carr’s index about 6% and angle of repose with 28. 770.Lavangadi vati suspension shown a pH in the normal range about 6.28 and having high sedimentation range and good redispersibility. Both the vati and modified suspension almost shown similar bands in TLC. Conclusion: After the evaluation of the various quality control parameters, prepared suspension having appropriate properties of a standard suspension without deviating from the classical lavangadi vati formulation.
Phytoestrogen: A protective shield for post-menopausal symptoms and breast cancer risk
Authors: Sawant Prajakta Dhairyashil , Tavhare Swagata Dilip
Published: January 2024

Menopause is a physiological unavoidable condition in women’s life which leads to vasomotor, psychological, urogenital and chronic diseases collectively termed as post-menopausal symptoms (PMS). Hormone replacement therapy (HRT) is conventional line of treatment for treating PMS in which estrogens replacement is major choice for better therapeutic efficacy against symptoms like hot flushes, osteoporosis, hormonal balances, insomnia, obesity etc. However, estrogen is reported risk factor for breast cancer. The review discusses Ayurveda based strategies for management of PMS with phytoestrogen herbs, diet, lifestyle modification, de-addiction measures, yoga, aroma therapies etc. supported by evidence-based documentation.Herbs namely Dhanyaka (Coriander sativum), Manjishtha (Rubia cordifolia L), Chandana (Santalum album L), Ashwagandha (Withania somnifera L. Dunal), Jatamansi (Nardostachys jatamansi DC), Shatavari (Asparagus racemosus L), Kumari (Aloe vera L), Yashtimadhu (Glycyrrhiza glabra L), Haridra (Curcuma longa L), Triphala (Combination of fruits of Haritaki, Bibhitak, Amalaki in the proportion 1:2:4), Gokshura (Tribulus terrestris L), Arjuna (Terminalia Arjuna L.), Guduchi (Tinospora cordifolia L.), Ela (Elettaria cardamomum L), Narikela (Coccus nucifera L), Masha (Phaseolus vulgaris L), Mudga (Vigna radiata L). Shunthi (Zinziber officinale Roxb), Methika (Trigonella foenumgraecum L), Tila (Sesamum indicum L) are the natural sources of phytoestrogens. Phytoestrogen don’t exert side effects like synthetic estrogen molecules. These herbs are useful for management of various symptoms of PMS. Having anti-cancer potential against breast carcinoma these are useful for prevention of risk of breast cancer.
Commentary: Antibiotic Resistance, Sustainable Development 2030 and Poverty in Developing Countries
Authors: Jawad A.
Published: January 2024

Sustainable Development - 2030 is poised for a transformative global landscape, marked by two pressing challenges: antibiotic resistance, an escalating public health crisis, and the pursuit of Sustainable Development Goals (SDGs) to alleviate poverty and enhance living standards. This commentary explores the intricate relationship between antibiotic resistance, the 2030 agenda for sustainable development, and poverty in developing countries. Antibiotic resistance, primarily fuelled by overuse and misuse, threatens to intensify the burden of infectious diseases, particularly among vulnerable populations. Concurrently, sustainable development in these regions is beset with hurdles. Eradicating poverty, a central SDG-2030 goal hinges on addressing healthcare disparities and the impacts of antibiotic resistance. This in-depth analysis comprehensively examines the complex interplay of these factors, evaluating the challenges they pose to the SDGs-2030. It assesses the current state of sustainable development and its potential to uplift impoverished communities, highlighting the consequences of antibiotic resistance on healthcare access and the challenges related to achieving food security amid antibiotic residues. The paper explores strategies and obstacles in the dual pursuit of poverty elimination and antibiotic resistance mitigation, emphasizing the need for holistic, evidence-based solutions across social, economic, environmental, and health dimensions. These commentaries offer insights and recommendations to inspire proactive efforts towards a more equitable and sustainable future.