bluuebunny/crossref_metadata_2025 huggingface dataset:
Mobilising knowledge in complex health systems: a call to action
Authors: Holmes Bev J , Best Allan , Davies Huw , Hunter David , Kelly Michael P , Marshall Martin , Rycroft-Malone Joanne
Published: November 2016

Worldwide, policymakers, health system managers, practitioners and researchers struggle to use evidence to improve policy and practice. There is growing recognition that this challenge relates to the complex systems in which we work. The corresponding increase in complexity-related discourse remains primarily at a theoretical level. This paper moves the discussion to a practical level, proposing actions that can be taken to implement evidence successfully in complex systems. Key to success is working with, rather than trying to simplify or control, complexity. The integrated actions relate to co-producing knowledge, establishing shared goals and measures, enabling leadership, ensuring adequate resourcing, contributing to the science of knowledge-to-action, and communicating strategically.
The historical panorama in post-1974 Greek cinema: The Travelling Players, Stone Years, Crystal Nights, The Weeping Meadow
Authors: Mini Panayiota
Published: November 2016

Unlike the majority of Greek historical films made before 1974, which dramatized specific events, after 1974 some leading Greek film-makers shot historical panoramas, whose plots spanned many periods. This article analyses four such historical panoramas that cover roughly similar periods, Angelopoulos’s O Thiasos/The Travelling Players (1975) and To Livadi pou Dakrizei/The Weeping Meadow (2004), Voulgaris’s Petrina Hronia/Stone Years (1985) and Marketaki’s Kristallines Nihtes/Crystal Nights (1992). The article situates each film within its broader cultural context and identifies the forces that motivate the history’s development, the plot’s logic and its formal substantiation. Each film, the article shows, suggests a different ‘historical cause’ for the events it depicts, ranging from imperialist processes and immanent human traits to psychoanalytic and mythological drives, and uses distinct formal means to convey the events. The examination of these four historical panoramas also attests to the gradual ‘de-politicization’ of auteur Greek cinema, in addition to prompting us to reflect on the various cinematic forms through which history can be represented and the different ways in which historical events can be linked and interpreted.
Sex, violence, dogs and the impossibility of escape: Why contemporary Greek film is so focused on family
Authors: Aleksić Tatjana
Published: November 2016

The article reads two recent Greek films, Kinodontas/Dogtooth (Lanthimos, 2009) and Miss Violence (Avranas, 2013), as offering a critique of the model of family repression. It argues that the films in their seemingly different aesthetic choices make similar points about the familial necropolitics that does not merely reflect social pathologies but likely also produces them. The families in both films are exposed to forms of control by a fatherly figure who dominates and almost entirely determines the content of the families’ daily lives. They inhabit lives and living spaces that visually, as well as narratively, offer no space for dissent or escape. However, the family members themselves, and especially their mother figures, are likewise perceived as semi-willing accomplices in the repressive scheme, as afraid of the male tyrants, as of the idea of their own liberation. Overall, the article argues that while the family control mechanisms presented in these and other recent Greek films can be read in response to the contemporary Greek crisis, this need not be the case, as the reach and implications of their critique are far wider.
The mother accomplice: Questions of representation in Dogtooth and Miss Violence
Authors: Kazakopoulou Tonia
Published: November 2016

This article seeks to raise some questions and open a conversation on issues relating to the representation of the mother-figure, of motherhood, and by extension of women in contemporary Greek cinema. Focusing on Yorgos Lanthimos’s Kynodontas/Dogtooth (2009) and Alexandros Avranas’s Miss Violence (2013), the article argues that, despite their overall unconventional approach in terms of content and form, both films remain rather conventional in their regressive representations of the character of the mother, who is characterized by her paradoxical conceptualization as an active accomplice without agency within the patriarchal universe of both films. In a broader sense, the article (re)turns to established feminist scholarship in insisting on the ‘woman question’ so often neglected in Greek film criticism more generally, and in relation to the selected films more specifically.
Aesthetics of recession: Urban space and identity in Attenberg and Beautiful Youth
Authors: Karkani Ina
Published: November 2016

The contemporary cinemas of the European countries directly involved with the current socio-economic crisis, such as Greece and Spain, have become key cultural areas in which urban space and social identity is imagined. Films such as Attenberg (Tsangari, 2010) and Hermosa Juventud/Beautiful Youth (Rosales, 2014) come from different cultural backgrounds and are examples of films that establish a powerful semiotic relationship between aesthetics and politics to give cinematic space a new meaning by tapping into a nexus of ideas about time and subjectivity. The films bear striking similarities in their articulation of the latest economic crisis through images of urban recession and their manifestation of social identity. Commonalities can be detected in stylistic and narrational strategies, thematic motifs, characterization and plot construction, and the use of film technology. This article explores the ways in which these images are related and articulate the current social reality in South European cities narratively, stylistically and formally. Bringing Walter Benjamin’s ‘aestheticizing politics’ of urban space in dialogue with Michel Foucault’s concept of ‘desubjectification’, this article is interested in investigating the links between subjective experience and urban space in South European cities hit by the recession.
Contemporary Greek horror cinema: Yes! It is a ‘Thing’!
Authors: Fotiou Mikela
Published: November 2016

Although horror films are quite prevalent in Hollywood as well as in various national cinemas, they are not so in the tradition of Greek cinema. However, there are several Greek horror films as well as film-makers – both amateur and professional – working on the genre. This article provides an overview of contemporary horror cinema in Greece, briefly discussing its background and highlighting a change both in the quantity and quality of Greek horror films after 2010. The article also presents key themes found in Greek horror films and traces threads that connect the films while also noting the ways recent horror films have been influenced by and commented upon the Greek economic and sociopolitical crisis. It situates these films in an emerging culture that surrounds, sustains, and seeks to develop this phenomenon in Greece. Finally, the article is followed by an appendix that offers a chronologically organized indicative list of Greek horror films encountered online during this research from early precursors in the mid-1970s to the more recent production discussed in the article, from 2004 down to the present.
Treatment of type 2 diabetes: the stability of the effectiveness of hypoglycemic medications
Authors: Morgunova Tat'yana , Fadeev Valentin
Published: November 2016

This article is dedicated to the problem of glycaemic durability of drugs used in treatment of type 2 diabetes. The results of studies comparing durability of glycemic control as monotherapy or in combination of metformin with different drugs: dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, sulfonylurea, inhibitors of sodium-glucose cotransporter-2 are shown. The article discusses the results of original research and meta-analysis.
Contraception in obese women
Authors: Andreeva Elena , Sokolova Dar’y , Grigoryan Ol'ga
Published: November 2016

At present, the prevalence of overweight people in the world is more than 1.7 billion; 312 million people are obese. The 25% of them consist of reproductive age women. In the modern world contraception is not only the way to prevent unscheduled pregnancy but also the opportunity to treat endocrine and gynecological diseases. While choosing the method of contraception, it is important to realize it’s pharmacological effect on carbohydrate and lipid metabolism, hemocoagulation/fibrinolysis system, cardiovascular and other systems of body that are involved in cascade of pathological processes. Selection of contraception for overweight/obese patients needs an individualized approaches with evaluation of efficiency/risk for every specific method of fertility correction.
Chronic kidney disease progression in a patient with primary hyperparathyroidism
Authors: Mirnaya Svetlana Sergeevna , Mokrysheva Natalia Georgievna
Published: November 2016

Nowadays cases of severe primary hyperparathyroidism (PHPT) are rare. Doctors of different specialties are informed better about PHPT “masks” and overall PHPT is diagnosed much earlier. We present a case report of a patient with nephrolithiasis and primary hyperparathyroidism with both bone and visceral complications, who showed deterioration of renal function up to chronic kidney disease stage 5 and was referred to renal transplantation.
Integration oder Interkultur?
Authors: Teissl Verena , Allmanritter Vera , Türk Jasmin , Bubik Theresa , Schairer Lea , Breindl Jasmin
Published: November 2016

Im Rahmen eines studentischen Praxisprojektes und unterstützt vom Kulturamt der Stadt Innsbruck wurde von März 2014 bis Februar 2015 eine dreistufige Studie zum Thema Kulturnutzung von MigrantInnen in Innsbruck (Arbeitstitel) unternommen. Die Ergebnisse wurden schließlich unter den Titel Interkulturalität in und von Innsbrucker Kultureinrichtungen gestellt. Sowohl der Entwicklungsprozess als auch die Umsetzung in Form qualitativer Sozialforschung und deren Interpretation brachten vielschichtige, z. T. verallgemeinerbare Ergebnisse für kulturmanageriale Theorienbildung und Handlungsempfehlungen zu Tage, welche im Folgenden vorgestellt und kontextualisiert werden. Der dritte Teil der Studie, die Kernergebnisse und Handlungsempfehlungen gestützt auf Interviews mit Experten und Expertinnen und Erfahrungen von „MigrantInnen“, ist auf der Plattform Kulturvermittlung Online der Universität Hildesheim einsehbar (TEISSL u. a. 2015).
Solving volterra integral equation via nonlinear programming
Authors: Othman Jamal
Published: November 2016

In this paper we propose an approach to find approximate solution to the nonlinear Volterra integral equation of the second type through a nonlinear programming technique by firstly converting the integral equation into a least square cost function as an objective function for an unconstrained nonlinear programming problem which solved by a nonlinear programming technique (The preconditioned limited- memory quasi-Newton conjugates, gradient method) and as far as we read this is a new approach in the ways of solving the nonlinear Volterra integral equation. We use Maple 11 software as a tool for performing the suggested steps in solving the examples.
Haploinsufficiency of the folliculin gene leads to impaired functions of lung fibroblasts in patients with Birt–Hogg–Dubé syndrome
Authors: Hoshika Yoshito , Takahashi Fumiyuki , Togo Shinsaku , Hashimoto Muneaki , Nara Takeshi , Kobayashi Toshiyuki , Nurwidya Fariz , Kataoka Hideyuki , Kurihara Masatoshi , Kobayashi Etsuko , Ebana Hiroki , Kikkawa Mika , Ando Katsutoshi , Nishino Koichi , Hino Okio , Takahashi Kazuhisa , Seyama Kuniaki
Published: November 2016

Birt–Hogg–Dubé syndrome (BHDS) is an autosomal dominant inherited disorder caused by germline mutations in the FLCN gene, and characterized by skin fibrofolliculomas, multiple lung cysts, spontaneous pneumothorax, and renal neoplasms. Pulmonary manifestations frequently develop earlier than other organ involvements, prompting a diagnosis of BHDS. However, the mechanism of lung cyst formation and pathogenesis of pneumothorax have not yet been clarified. Fibroblasts were isolated from lung tissues obtained from patients with BHDS (n = 12) and lung cancer (n = 10) as controls. The functional abilities of these lung fibroblasts were evaluated by the tests for chemotaxis to fibronectin and three‐dimensional (3‐D) gel contraction. Fibroblasts from BHDS patients showed diminished chemotaxis as compared with fibroblasts from controls. Expression of fibronectin and TGF‐β1 was significantly reduced in BHDS fibroblasts when assessed by qPCR. Addition of TGF‐β1 in culture medium of BHDS lung fibroblasts significantly restored these cells' abilities of chemotaxis and gel contraction. Human fetal lung fibroblasts (HFL‐1) exhibited reduced chemotaxis and 3‐D gel contraction when FLCN expression was knocked down. To the contrary, a significant increase in chemotactic activity toward to fibronectin was demonstrated when wild‐type FLCN was overexpressed, whereas transduction of mutant FLCN showed no effect on chemotaxis. Our results suggest that FLCN is associated with chemotaxis in lung fibroblasts. Together with reduced TGF‐β1 expression by BHDS lung fibroblasts, a state of FLCN haploinsufficiency may cause lung fibroblast dysfunction, thereby impairing tissue repair. These may reveal one mechanism of lung cyst formation and pneumothorax in BHDS patients.
Intention–Behavior Discrepancy of Foreign versus Domestic Brands in Emerging Markets: The Relevance of Consumer Prior Knowledge
Authors: Sun Luping , Zheng Xiaona , Su Meng , Keller L. Robin
Published: November 2016

Most research on the performance of foreign versus domestic brands in emerging markets has examined dependent measures of product evaluation or purchase intention. However, consumers who intend to buy a product may switch to competing brands, thus displaying an intention–behavior discrepancy (IBD). Drawing on literature on country associations and dual process theory, the authors examine the performance of foreign versus domestic brands on IBD in emerging markets and the moderating role of consumer prior knowledge. They conduct an intention survey followed by a postpurchase survey in the Chinese automobile and smartphone industries and find that foreign brands have an advantage on IBD relative to domestic brands, indicating that they have the dual advantage of higher evaluations and lower IBDs. Furthermore, foreign brands’ advantage on IBD is smaller for consumers with inaccurate prior knowledge because they are more likely to systematically reprocess information and discount foreign brands’ favorable country associations. For these consumers, overestimating the product reduces foreign brands’ advantage to a lesser degree than underestimating it as a result of confirmation bias. These findings provide implications for brands in emerging markets.
Understanding External and Cascading Benefits for HIV/AIDS Control in a Subsistence Marketplace: Insights from Indonesia
Authors: Arli Denni , Cadeaux Jack
Published: November 2016

The objectives of this study are (1) to examine user perceptions and preferences toward various HIV/AIDS prevention control products and services and (2) to explore how both perceived likelihood of infection and beliefs about external benefits might distinctively affect intentions to use various HIV/AIDS-prevention goods and services in poor communities. The study compares a sample drawn from a subsistence marketplace (a red-light district in a major city) with one drawn from a relatively non–subsistence marketplace (a university area in the same city) in Indonesia. In spite of significant differences in education, income, and sexual activity, the two samples show a surprising degree of similarity in generic positioning maps for the six HIV/AIDS-prevention goods and services. Quite concerning, though, is the finding that in the higher-risk, subsistence setting, individuals actually infected with HIV are less likely to use HIV/AIDS-prevention goods and services than are those who are not infected. The authors review these empirical results in light of (1) theories of external, cascading benefits, and generalized exchange and (2) a theory of subsistence marketplaces in developing economies.
Simulation of In-Flight Reduction of the Fine Iron Ore Concentrate by Hydrogen
Authors: Abolpour Bahador , Afsahi M. Mehdi , Goharrizi Ataallah Soltani , Azizkarimi Mehdi
Published: November 2016

A mathematical model has been proposed to simulate a novel method for direct reduction of iron concentrate by hydrogen. Flight of fine particles in a vertical reactor containing a gaseous mixture of H2-N2-H2O has been studied. Effect of generating gaseous jet on the residence time of the particles has been also investigated. Coupled turbulent Navier-Stokes equations with eddy kinetic energy equation have been solved using a developed homemade code. Kinetics of this reaction has been studied using the unreacted core model. Accuracy of the model predictions has been approved by the experimental data. Finally, effects of vital variables (i. e. temperature, particle size, hydrogen concentration and particle feed rate) on the particle residence time and also fractional conversion have been studied.
A proximity based macro stress testing
framework
Authors: Waelchli Boris
Published: November 2016

In this a paper a non-linear macro stress testing methodology with focus on early warning is developed.
The methodology builds on a variant of Random Forests and its proximity measures. It is embedded
in a framework, in which naturally defined contagion and feedback effects transfer the impact of stressing a
relatively small part of the observations on the whole dataset, allowing to estimate a stressed future state. It
will be shown that contagion can be directly derived from the proximities while iterating the proximity based
contagion leads to naturally defined feedback effects. Since the methodology is Random Forests based the
framework can be estimated on large numbers of risk indicators up to big data dimensions, fostering the stability
of the results while reducing inaccuracies in estimated stress scenarios by only stressing a small part of
the observations. This procedure allows accurate forecasting of events under stress and the emergence of a
potential macro crisis. The framework also estimates a set of the most influential economic indicators leading
to the potential crisis, which can then be used as indications of remediation or prevention.
Luminescence chronology of alluvial fan in North Bengal, India: Implications to tectonics and climate
Authors: Singh Atul K. , Jaiswal Manoj K. , Pattanaik Jitendra K. , Dev Maha
Published: November 2016

Alluvial fans are important geomorphic archives because of its strategic location at mountain front which can provide clues to the past climate and tectonics. In general, they provide information about optimum climate condition suitable for fan formation. We provide a detailed luminescence chronology of alluvial fan in north West Bengal, India. The regional fan surface (T44) has been dissected by E-W trending Himalayan thrusts known as Matiali and Chalsa thrusts and have various terraces named as T3, T2 and youngest one as T1. Luminescence ages suggest that the formation of the alluvial fan (regional surface) started before 171 ka and continued till 72 ka covering a time span of nearly 100 ky; suggesting of weaker monsoon at 72 ka. Matiali fault activated after 171 ky. Chalsa fault is suggested to be active during 48–41 ka. The last aggradational phase was around 6 ka which led to the formation of T1a terrace. The study suggests that climatic fluctuation during the period were shaping the morphology of the alluvial fan, along with tectonic activities on the two faults.
Some non-unique fixed point theorems of Ćirić type using rational-type contractive conditions
Authors: Olatinwo Memudu Olaposi
Published: November 2016

In this paper, we prove some fixed point theorems of Ćirić type for mappings having non-unique fixed points by employing rational-type contractive conditions and the notion of comparison functions. Our results are generalizations, extensions and improvements of some previous and corresponding results in the literature.
Safe Distance, Dark Tourism, and Ambivalent Spatial Relation in Gillian Plowman’s Yours Abundantly, From Zimbabwe, and Christine Evans’s Trojan Barbie
Authors: Dundar Eda Dedebas
Published: November 2016

Colonial adventures and imperialistic travels have taken a new pattern as in the cases of humanitarian travel and dark tourism in the twenty-first century. Dark tourism not only satisfies Western individual’s hunger for orientalism labeling the touristic site a marginal and exotic landscape, but also uncovers the touristic undercurrents involved in the voyage. In this article, by utilizing the immediacy of the theatre genre, I argue that dramatic literature shares similar ambivalent spatial relations with humanitarian travel in that they both locate themselves between proximity and remoteness in their relation to the other. Similarly, by staging metatheatrical aspects, Plowman’s
Dismantling Recognition: Reading Isolation in The Goat
Authors: Lucas Kristin
Published: November 2016

Edward Albee’s play
People, Places & Things: Addiction, Identity and Performance
Authors: Paull Michelle
Published: November 2016

Duncan Macmillan’s
“A community of storytellers and translators”: Ubu and the Truth Commission
Authors: Planche Jill
Published: November 2016

Does the space of performance play a dynamic role in South Africa twenty years after the end of apartheid? Can theatre tell the stories that resonate in a landscape of ambiguity and uncertainty, where fragile and fractured memories remain concealed? The post-apartheid milieu produces a complex audience dislocated by spaces of inherited physical and mental boundaries. Theatre played an important oppositional role during apartheid. Now, the challenge for theatre is far more entangled and calls for theatre-making that heightens the community’s critical social and political reflection.
Synthesis and crystal structure of [2-(menthoxycarbonyl)ethyl]tris(8-quinolinato)tin
Authors: Tian Laijin , Zhang Shuai , Yao Yanze , Shi Xiaowen
Published: November 2016

In this study, [2-(Menthoxycarbonyl)ethyl]tris(8-quinolinato)tin, MenOCOCH
The crystal structure of 1-(4-bromophenyl)-2-(4-(4-fluorophenyl)piperazin-1-yl)ethanol, C18H20BrFN2O1
Authors: Zhang Yang , Wang Su , Sun Juan
Published: November 2016

C18H20BrFN2O1, monoclinic, P21/c (no. 14), a = 14.1884(10) Å, b = 5.3673(4) Å, c = 22.3768(15) Å, β = 93.293(2)°, V = 1701.3(2) Å3, Z = 4, Rgt(F) = 0.0510, wRref(F2) = 0.1384, T = 273 K.
Applicability of biobased packaging materials for long shelf-life food products
Authors: Peelman Nanou , Ragaert Peter , Verguldt Elien , Devlieghere Frank , De Meulenaer Bruno
Published: November 2016

The research aim was to evaluate the applicability of biobased plastics for packing long shelf-life food products, both on laboratory and industrial scale. Therefore, the shelf-life (room temperature) of tortilla chips, dry biscuits and potato flakes packed under air or modified atmosphere (MAP) in xylan and cellulose-based packages was evaluated and compared with their shelf-life in reference (conventional) packaging materials. These tests were followed by packaging trials on industrial lines. Furthermore, overall migration studies and printability tests were performed. Most of the biobased packages showed sufficient barrier towards moisture and gasses to serve as a food packaging material and MAP packaging of long shelf-life food products is possible. But for very moisture-sensitive food products (e.g. dry biscuits), no suited packaging material was found. The quality of the tortilla chips and potato flakes could be guaranteed during their shelf-life, even if packaging materials with lower barrier properties were used. Still, brittleness and seal properties are critical for use on industrial scale (important for use on vertical flow packaging machines). Furthermore, the films were printable and migration tests showed compliance with legislation. This study shows promising results towards the industrial application of biobased packaging materials for long shelflife food products.
Genealogie als intertextuelles Spiel
Authors: Schollmeyer Jonas
Published: November 2016

In Book 1 of theArgonautica, Apollonios Rhodios counts out the names of 55 heroes who set off to win the Golden Fleece. All the heroes are given genealogical details that often contribute to their characterisation. Only Admetus’ γενεή is passed over in silence by the catalogue. This was noted already by H. Fränkel, who suspected a lacuna in the text. However, there is another solution to the problem. The distinctive relationship of Admetus to his parents is detailed nowhere more clearly and drastically than in Euripides’Alcestis. In what is perhaps the most bitter agon in Greek tragedy, the father and son quarrel so severely that Admetus throws his parents out of the house and from then on wishes not to be regarded as their son. Apollonios assumes a knowledge of this famous quarrel among his readers or hearers, and he shows the sad consequences of this unreconciled generational conflict by breaking the convention of filiation and silently calling to mind the unresolved problems of theAlcestis.
The Problem of the Instrument Stabilization During Hydrographic Measurements
Authors: Felski Andrzej , Naus Krzysztof , Wąż Mariusz
Published: November 2016

Performing any measurement on watercraft is connected with many additional difficulties caused by the sea-environment. The most important is the problem of spatial stabilization of measurement systems, which are usually fastened to craft body. As soon as usually these measurement are executed during the move of the craft additional question is the accuracy of execution the planed trajectory.

This is a problem for all investigators, especially when system use spatially configured beams of any antennas or other sensors, regardless is it receiving or transmitting one.

Different aspects of these question are the subject of research activity of Institute of Navigation and Maritime Hydrography of Polish Naval Academy. In this paper the review of works executed in last years are presented.
Geodetic and Geodynamic Studies at Department of Geodesy and Geodetic Astronomy Wut
Authors: Brzeziński Aleksander , Barlik Marcin , Andrasik Ewa , Izdebski Waldemar , Kruczyk Michał , Liwosz Tomasz , Olszak Tomasz , Pachuta Andrzej , Pieniak Magdalena , Próchniewicz Dominik , Rajner Marcin , Szpunar Ryszard , Tercjak Monika , Walo Janusz
Published: November 2016

The article presents current issues and research work conducted in the Department of Geodesy and Geodetic Astronomy at the Faculty of Geodesy and Cartography at Warsaw University of Technology. It contains the most important directions of research in the fields of physical geodesy, satellite measurement techniques, GNSS meteorology, geodynamic studies, electronic measurement techniques and terrain information systems.
Vasculo-Neuronal Coupling: Retrograde Vascular Communication to Brain Neurons
Authors: Kim Ki Jung , Ramiro Diaz Juan , Iddings Jennifer A. , Filosa Jessica A.
Published: November 2016

Continuous cerebral blood flow is essential for neuronal survival, but whether vascular tone influences resting neuronal function is not known. Using a multidisciplinary approach in both rat and mice brain slices, we determined whether flow/pressure-evoked increases or decreases in parenchymal arteriole vascular tone, which result in arteriole constriction and dilation, respectively, altered resting cortical pyramidal neuron activity. We present evidence for intercellular communication in the brain involving a flow of information from vessel to astrocyte to neuron, a direction opposite to that of classic neurovascular coupling and referred to here as vasculo-neuronal coupling (VNC). Flow/pressure increases within parenchymal arterioles increased vascular tone and simultaneously decreased resting pyramidal neuron firing activity. On the other hand, flow/pressure decreases evoke parenchymal arteriole dilation and increased resting pyramidal neuron firing activity. InGLAST-CreERT2;R26-lsl-GCaMP3mice, we demonstrate that increased parenchymal arteriole tone significantly increased intracellular calcium in perivascular astrocyte processes, the onset of astrocyte calcium changes preceded the inhibition of cortical pyramidal neuronal firing activity. During increases in parenchymal arteriole tone, the pyramidal neuron response was unaffected by blockers of nitric oxide, GABAA, glutamate, or ecto-ATPase. However, VNC was abrogated by TRPV4 channel, GABAB, as well as an adenosine A1receptor blocker. Differently to pyramidal neuron responses, increases in flow/pressure within parenchymal arterioles increased the firing activity of a subtype of interneuron. Together, these data suggest that VNC is a complex constitutive active process that enables neurons to efficiently adjust their resting activity according to brain perfusion levels, thus safeguarding cellular homeostasis by preventing mismatches between energy supply and demand.

SIGNIFICANCE STATEMENTWe present evidence for vessel-to-neuron communication in the brain slice defined here as vasculo-neuronal coupling. We showed that, in response to increases in parenchymal arteriole tone, astrocyte intracellular Ca2+increased and cortical neuronal activity decreased. On the other hand, decreasing parenchymal arteriole tone increased resting cortical pyramidal neuron activity. Vasculo-neuronal coupling was partly mediated by TRPV4 channels as genetic ablation, or pharmacological blockade impaired increased flow/pressure-evoked neuronal inhibition. Increased flow/pressure-evoked neuronal inhibition was blocked in the presence of adenosine A1 receptor and GABABreceptor blockade. Results provide evidence for the concept of vasculo-neuronal coupling and highlight the importance of understanding the interplay between basal CBF and resting neuronal activity.
Comorbidities, treatment patterns and cost-of-illness of acromegaly in Sweden: a register-linkage population-based study
Authors: Lesén Eva , Granfeldt Daniel , Houchard Aude , Dinet Jérôme , Berthon Anthony , Olsson Daniel S , Björholt Ingela , Johannsson Gudmundur
Published: November 2016

Objective

Acromegaly is a complex endocrine disease with multiple comorbidities. Treatment to obtain biochemical remission includes surgery, medical therapy and radiation. We aimed to describe comorbidities, treatment patterns and cost-of-illness in patients with acromegaly in Sweden.

Design

A nationwide population-based study.

Methods

Patients with acromegaly were identified and followed in national registers in Sweden. Longitudinal treatment patterns were assessed in patients diagnosed between July 2005 and December 2013. The cost-of-illness during 2013 was estimated from a societal perspective among patients diagnosed between 1987 and 2013.

Results

Among 358 patients with acromegaly (48% men, mean age at diagnosis 50.0 (s.d. 15.3) years) at least one comorbidity was reported in 81% (n = 290). The most common comorbidities were hypertension (40%, n = 142), neoplasms outside the pituitary (30%, n = 109), hypopituitarism (22%, n = 80) and diabetes mellitus (17%, n = 61). Acromegaly treatment was initiated on average 3.7 (s.d. 6.9) months after diagnosis. Among the 301 treated patients, the most common first-line treatments were surgery (60%, n = 180), somatostatin analogues (21%, n = 64) and dopamine agonists (14%, n = 41). After primary surgery, 24% (n = 44) received somatostatin analogues. The annual per-patient cost was €12 000; this was €8700 and €16 000 if diagnosed before or after July 2005, respectively. The cost-of-illness for acromegaly and its comorbidities was 77% from direct costs and 23% from production loss.

Conclusions

The prevalence of comorbidity is high in patients with acromegaly. The most common first-line treatment in acromegalic patients was surgery followed by somatostatin analogues. The annual per-patient cost of acromegaly and its comorbidities was €12 000.
Silent somatotroph tumour revisited from a study of 80 patients with and without acromegaly and a review of the literature
Authors: Chinezu Laura , Vasiljevic Alexandre , Trouillas Jacqueline , Lapoirie Marion , Jouanneau Emmanuel , Raverot Gérald
Published: November 2016

Background

Silent somatotroph tumours are growth hormone (GH) immunoreactive (IR) pituitary tumours without clinical and biological signs of acromegaly. Their better characterisation is required to improve the diagnosis.

Materials and methods

Twenty-one silent somatotroph tumours were compared to 59 somatotroph tumours with acromegaly. Tumours in each group were classified into GH and plurihormonal (GH/prolactin (PRL)/±thyroid-stimulating hormone (TSH)) and into densely granulated (DG) and sparsely granulated (SG) types. The two groups were then compared with regards to proliferation (Ki-67, p53 indexes and mitotic count), differentiation (expression of somatostatin receptors SSTR2A–SSTR5 and transcription factor Pit-1) and secretory activity (% of GH- and PRL-IR cells).

Results

The silent somatotroph tumours represented 2% of all tested pituitary tumours combined. They were more frequent in women than in men (P = 0.002), more frequently plurihormonal and SG (P < 0.01), with a lower percentage of GH-IR cells (P < 0.0001) compared to those with acromegaly. They all expressed SSTR2A, SSTR5 and Pit-1. The plurihormonal (GH/PRL/±TSH) tumours were mostly observed in women (sex ratio: 3/1) and in patients who were generally younger than those with acromegaly (P < 0.001). They were larger (P < 0.001) with a higher Ki-67 index (P = 0.007).

Conclusions

The silent somatotroph tumours are not uncommon. Their pathological diagnosis requires the immunodetection of GH and Pit-1. They are more frequently plurihormonal and more proliferative than those with acromegaly. A low secretory activity of these tumours might explain the normal plasma values for GH and insulin-like growth factor 1 (IGF1) and the absence of clinical signs of acromegaly.
Microencapsulación mediante secado por aspersión de aceite de mora (Rubus glaucus) extraido con CO2 supercrítico
Authors: Figueroa Martínez Paola Milena , Hurtado Benavides Andrés Mauricio , Ceballos Ortíz Miguel Angel
Published: November 2016

El aceite de mora es un ingrediente natural con potencial en la industria cosmética y alimentaria, a su vez puede experimentar degradación oxidativa en condiciones ambientales. Por ello, se extrajo aceite a partir de semillas de mora empleando fluidos supercríticos y, posteriormente, se microencapsuló mediante secado por aspersión y se  evaluó la influencia de diferentes condiciones de operación en el rendimiento, y la eficiencia del proceso. Se emplearon como materiales encapsulantes: masterdry, goma arábiga y maltodextrina. Se estudió el tamaño y morfología de las microcápsulas. Se determinó que en el proceso de microencapsulación la temperatura de entrada fue la única variable estadísticamente significativa que afectó el rendimiento y la eficiencia, cuando se usaron como encapsulantes masterdry y goma arábiga. El caudal de alimentación fue estadísticamente significativo sólo para el rendimiento del proceso y lo influenció negativamente cuando se usó maltodextrina. La goma arábiga resultó ser el mejor encapsulante entre los tres estudiados. Se obtuvieron microcápsulas con tamaños entre 8,2 y 14 μm, con superficie continua en las paredes y ausencia de poros. Se comprobó que la microencapsulación con los tres encapsulantes permitió proteger el aceite y conservar mayoritariamente su perfil de ácidos grasos.
Determinación del contenido extra e intracelular de algunas enzimas líticas relacionadas con pared celular en raíces de clavel (Dianthus caryophyllus L.)
Authors: Martínez Peralta Sixta Tulia , Ramínez Vargas Edilene
Published: November 2016

En el presente trabajo se verificó la presencia de algunas enzimas relacionadas con la pared celular vegetal (poligalacturonasa, pectato liasa, proteasa y xilanasa) en raíces de clavel (Dianthus caryophyllus L.). Así mismo, se determinaron los niveles de actividad de las mismas. Estos niveles se analizaron en diferentes espacios celulares: en el fluido intercelular que hace parte del apoplasto, en el simplasto y en el tejido total de las raíces de clavel (apoplasto y simplasto).Para extraer el fluido intercelular, se ensayaron dos metodologías. Para obtener el contenido intracelular (simplasto) y el extracto total (apoplasto y simplasto) en raíces de clavel se ensayaron tres metodologías que utilizaban como solución i) extractante buffer fosfato, ii) buffer fosfato con PVPP y iii) lavados con acetona a las raíces de clavel, antes de la extracción con buffer fosfatos. Los resultados mostraron el efecto de las diferentes soluciones en las actividades enzimáticas y en el contenido de proteína. Se propuso una de estas metodologías para extraer las cuatro enzimas en un único paso y realizar análisis comparativo de actividad enzimática.
Caracterización de los compuestos del aroma en rones colombianos por HS-SPME-GC-MS-O
Authors: Osorio Monsalve Jazmín , López Córdoba Carlos Alberto , Zapata Ochoa Julián Andrés
Published: November 2016

Se identificaron por primera vez 46 compuestos volátiles olfativamente activos con actividad aromática significativa presentes en rones comerciales de Colombia. Lo anterior, mediante microextracción en fase sólida en modo espacio de cabeza (HS-SPME), acoplada a cromatografía de gases con detectores de espectrometría de masas y olfatometría (GC-MS-O). Dentro de los compuestos identificados se encuentran ésteres, compuestos aromáticos, alcoholes, acetales, lactonas y furfural. De esos 46 compuestos, nueve están presentes en todos los rones estudiados y algunos otros son característicos solo de la marca.
Pemeliharaan Benih ikan Botia (Chrombotia macracanthus Bleeker) dengan Salinitas yang Berbeda
Authors: Sugito Slamet , Herminawati Sri Cahyaningsih
Published: November 2016

Abstrak lengkap dapat dilihat pada full. PDFKegiatan ini bertujuan untuk mengetahui pengaruh salinitas yang berbeda terhadap sintasan dan pertumbuhan ikan botia
Pemeliharaan Calon Induk Ikan Bandeng Chanos chanos Asal Aceh dan Bali dalam Bak terkontrol
Authors: Romdlianto Muslim , Supriyatna Agus
Published: November 2016

Abstrak lengkap dapat dilihat pada full. PDFInduk yang berkualitas dapat diperoleh melalui usaha seleksi mulai dari fase benih, gelondongan maupun calon induk bandeng
Analisis Nutrisi daun Murbei (Morus alba L) Sebagai Bahan Substitusi Pakan Kepiting Bakau (Scylla serrata) untuk Produksi Kepiting Soka
Authors: Rosni Rosni , Tamsil Tamsil
Published: November 2016

Abstrak lengkap dapat dilihat pada full. PDFDaun murbei tergolomg dalam tanaman tingkat tinggi, tumbuh dengan baik pada ketinggian 100 m diatas permukaan air laut, daun murbei umumnya digunakan untuk makanan ulat sutra.
Teknik Mencampur Larutan Fiksasi untuk Histologi
Authors: Mujimin Mujimin , Suratmi Sri
Published: November 2016

Abstrak lengkap dapat dlihat pada full PDFFiksasi merupakan salah satu bagian dalam metode histologi. Fiksasi adalah pemberian perlakuan tertentu terhadap elemen elemen jaringan, terutam inti sel atau nukleusnya sehingga dapat diawetkan dalam kondisi yang sedikit banyak mendekati keadaan aslinya. Tujuan percobaaan ini adalah untuk mengetahui teknik mencampur larutan fiksasi yang digunakan untuk mengawetkan organ/jaringan ikan
Perbaikan Teknik Preservasi Sperma Ikan Lele ( Clarias Gariepinus) dalam Mendukung Keberhasilan Pemijahan Ikan
Authors: Suwargono Pudji
Published: November 2016

Abstrak lengkap dapat dilihat pada full. PDFIkan lele merupakan komoditas perikanan budidaya yang diunggulkan. Pengembangan budidaya ikan lele memerlukan benih dengan kualitas, kuantitas dan kontinuitas yang memadai
Teknik Aplikasi Vaksin Vibrio Polivalen melalui Perendaman pada ikan kerapu bebek (cromileptes altivelis) di Hatchery
Authors: Ansari Mohamad , Haryanto Slamet , Suratmi Sri
Published: November 2016

Abstrak lengkap dapat dilihat pada full PDFIkan kerapu bebek, Cromileptes altivelis merupakan salah satu komoditas unggulan budidaya di Indonesia karena memiliki nilai jual yang tinggi.Sejak spesies ini dikembangkan secara intensif, antara lain vibriosis. Tujuan kegiatan ini adalah untuk mengetahui respons yuwana ikan kerapu terhadap vaksin vibrio polivalen.
Kesesuaian dan Pengelolaan lahan budi daya tambak di Kabupaten Kotabaru, Kalimantan Selatan
Authors: Pantjara Brata , Aliman Aliman , Mangampa Markus , Pongsapan Daud , Utojo Utojo
Published: November 2016

Studi kesesuaian potensi pertambakan dilakukan di 3 Kecamatan Kabupaten Kotabaru, Kalimantan Selatan, meliputi: Kecamatan Pulau Laut Utara, Pulau Laut Tengah, dan Pulau Laut Barat. Tujuan penelitian adalah mengetahui potensi dan tingkat kesesuaian lahan budi daya tambak di Kabupaten Kotabaru, Kalimantan Selatan. Metode penelitian dengan melakukan survai untuk mendapatkan data primer. Data sekunder diperoleh dari wawancara pemilik/pembudi daya tambak dan data stastistik serta Laporan Tahunan Kabupaten Kotabaru, Kalimantan Selatan. Analisis data untuk mengetahui potensi dan kesesuaian lahan budi daya tambak dengan Sistem Informasi Geografis (SIG). Tingkat kesesuaian budi daya tambak diperoleh dengan cara tumpang susun beberapa peta dan data primer pada setiap pengamatan dengan mempertimbangkan pembobotan dan skala penilaian untuk mendapatkan nilai skoring. Hasil analisis potensi dan kesesuaian tambak di 3 Kecamatan Kabupaten Kotabaru mempunyai tingkat kesesuaian sedang. Potensi kelayakan lahan untuk tambak di Desa Stagen Kecamatan Pulau Laut Utara seluas 2.548,8 ha dengan teknologi budi daya tambak sistem ekstensif hingga semi intensif, Desa Sungai Pasir dan Sungai Paring Kecamatan Pulau Laut Tengah seluas 57,9 ha dengan teknologi budi daya ekstensif hingga semi intensif. Desa Sebanti Kecamatan Pulau Laut Barat seluas 516,8 ha dengan teknologi ekstensif hingga ekstensif plus.Land suitability study of brackish water pond was conducted at 3 District in Kotabaru Regency, South Kalimantan were Pulau Laut Utara, Pulau Laut Tengah, and Pulau Laut Barat. The objectives of research to know land suitability and management for brackishwater pond in Kotabaru Regency, South Kalimantan. Survey has been done collected primary data. While secondary data was obtained from questioner with the pond farmers and statistical data from related Institution. Data analysis to know of potency and land suitability for pond with Geographical Information System (GIS), with overlying maps and primary data in each station observation with considering and assessment scale value of determining land suitability for brackish water pond. The result of research that potency and land suitability of 3 District in Kotabaru Regency were moderate suitability. Land potency in Stagen and Sungai Paring Villages, Pulau Laut Utara District can reach 2,548.8 ha with application extensive until semi intensive technology. Sungai Pasir Village, Pulau Laut Tengah District can reach 57.9 ha with application extensive until semi intensive technology. Sebanti Village, Pulau Laut Barat District of 516.8 ha with application extensive until plus extensive technology.
Kebutuhan Vitamin C Untuk Pertumbuhan dan Meningkatkan Ketahanan Benih Kerapu Macan (Epinephelus fuscoguttatus)
Authors: Giri Nyoman Adiasmara , Johnny Fris , Suwirya Ketut , Marzuqi Muhammad
Published: November 2016

Penelitian untuk mengetahui kebutuhan vitamin C untuk pertumbuhan dan ketahanan benih ikan kerapu macan (Epinephelus fuscoguttatus) telah dilakukan, menggunakan 18 buah bak polikarbonat volume 100 liter yang dilengkapi dengan sistem air mengalir dan aerasi. Benih kerapu macan dengan bobot rata-rata 23,0 ± 0,1 gram ditebar dalam bak penelitian dengan kepadatan 12 ekor per bak. Ikan diberi pakan penelitian 2 kali sehari pada level satiasi selama 13 minggu. Pakan penelitian diformulasi dengan kandungan nutrien yang sama kecuali kandungan vitamin C. Pada formula pakan ditambahkan vitamin C (L-ascorbyl-2-phosphate Magnesium, APM) dengan dosis berbeda, yaitu 0, 15, 30, 60, 120, dan 250 mg/kg pakan. Pakan dibuat dalam bentuk pelet dan dikeringkan menggunakan freeze dryer. Penelitian dirancang menggunakan rancangan acak lengkap (RAL) dengan 6 perlakuan beda kandungan vitamin C dalam pakan dan setiap perlakuan terdiri atas 3 ulangan. Hasil penelitian menunjukkan bahwa ikan yang diberi pakan tanpa penambahan vitamin C pertumbuhannya, kadar hemoglobin dan hematokrit darah, aktivitas fagositik, dan indeks fagositiknya adalah paling rendah dibandingkan dengan kelompok ikan lainnya. Dari hasil ini disimpulkan bahwa diperlukan penambahan vitamin C sebanyak 30 mg/kg pakan untuk pertumbuhan ikan yang baik dan penambahan vitamin C sebanyak 60—120 mg/kg pakan untuk kesehatan ikan kerapu macan.The experiment to determine dietary vitamin C requirement for good growth of tiger grouper has been conducted in 18 polycarbonate tanks, 100 liters volume. Each tank is equipped with flow-through water system. Twelve juvenile of tiger grouper (23.0 ± 0.1 gram in body weight), which were produced in hatchery, were randomly selected and stocked in each tank. Fish fed by experimental diets twice everyday at satiation level for 13 weeks. Experimental diets were formulated to contain the same level of nutrients (protein, lipid, and energy), except for vitamin C. Graded level of vitamin C (L-ascorbyl-2-phosphate Magnesium, APM) were supplemented to experimental diet at the level of 0, 15, 30, 60, 120, and 250 mg/kg diet. Diets were prepared as pellet and dried using freeze dryer. The experiment was designed according to complete random design (CRD) with 6 treatments (vitamin C levels) and three replicates for each treatment. Result of the experiment showed that growth, blood hemoglobin and hematocrite, phagocytic activity, and phagocytic index of fish fed diet without supplemental vitamin C were the lowest. This result indicates that vitamin C is essential for tiger grouper. Tiger grouper juvenile requires supplemental 30 mg vitamin C (APM)/kg diet for good growth or 60—120 mg vitamin C for good health condition.