bluuebunny/crossref_metadata_2025 huggingface dataset:
Creating a Specialized Arduino-Powered Control Interface for Precise Management of Water Evaporation, Including Isothermal Transformation and Adaptive Pressure Modulation
Authors: Bougtaib Ayoub , Nfaoui Mohamed , Hayani-Mounir Sanaa , idrissi Moha El , Mejdal Mohamed
Published: January 2024

The fundamental objective of this experimental investigation is to methodically scrutinize the changes in the physical state of a chemically pure substance. This scrutiny involves the intentional manipulation of critical parameters, specifically temperature and pressure, to meticulously observe and comprehend the resultant transformations. The specific focus of this study is directed towards instigating the evaporation of water while maintaining a consistent temperature, with the variable of interest being the precise adjustment of pressure. This experimental design is rooted in the aspiration to elucidate the intricate interdependencies between pressure and the consequential physical state transitions of a substance. The primary emphasis is placed on discerning the nuanced processes involved in the transition from a liquid phase to a gaseous phase. The deliberate decision to isolate and vary solely the pressure parameter is driven by the quest to systematically explore and comprehend its substantial role in steering and modulating these transformations. The overarching rationale is predicated on the notion that through this focused manipulation of experimental conditions, participants can cultivate a more profound and sophisticated understanding of the underlying mechanisms governing these phenomena. This, in turn, serves to fortify their expertise in the specialized domains of thermodynamics and materials sciences. The experiment presents an empirical platform for participants to actively engage with and dissect how fluctuations in pressure exert a compelling influence on the metamorphosis of a substance, particularly within the contextual framework of transitioning from a liquid to a gaseous state. The insights derived from this scholarly inquiry are poised to contribute meaningfully to the existing body of knowledge in the field. Furthermore, they may offer practical implications for a broader comprehension of material behaviors under diverse thermodynamic conditions, thereby potentially informing advancements in related scientific and technological pursuits
Online and Offline Reading Materials from Students’ Perspective
Authors: Virgiyanti Diska Fatima , Fachriza Aries , Nuraini Eka Indah , Dipta Dinar , Hafiz Latifa Annisa
Published: January 2024

In this digital era, reading can be done anywhere and anytime. Nowadays, as the rapid development of technology, there are many learning sources available in online platform such as website. As a result, it also affected students’ habit in reading. Moreover, reading online is different from reading offline. In reading offline, the students need printed reading materials such as book, novel, newspaper, or magazine. However, offline reading does not need any printed materials, except the computer, laptop, or smart phone. Students often got difficulties in choosing their reading materials when they are given freedom to choose their own materials from online or offline sources. In this article, the researcher aimed to find out the students’ perspective toward reading using online and offline materials as well as its benefits and drawbacks. This research used descriptive qualitative research method. The researcher obtained the data from questionnaire, interview, and field observation. There were 25 students involved in this research. The findings indicated that students usually read in their free time, they are familiar with e-book materials, students’ reading motivation affected by formal features of a book, printed book is easier to be understood, both online and offline materials is interesting, online platform is more update in giving news, and they like to read book from both Indonesian and foreign authors.
Anatomy of the eigenstates distribution: A quest for a genuine multifractality
Authors: Kutlin Anton , Khaymovich Ivan M.
Published: January 2024

Motivated by a series of recent works, an interest in multifractal phases has risen as they are believed to be present in the Many-Body Localized (MBL) phase and are of high demand in quantum annealing and machine learning. Inspired by the success of the Rosenzweig-Porter (RP) model with Gaussian-distributed hopping elements, several RP-like ensembles with the fat-tailed distributed hopping terms have been proposed, with claims that they host the desired multifractal phase. In the present work, we develop a general (graphical) approach allowing a self-consistent analytical calculation of fractal dimensions for a generic RP model and investigate what features of the RP Hamiltonians can be responsible for the multifractal phase emergence. We conclude that the only feature contributing to a genuine multifractality is the on-site energies’ distribution, meaning that no random matrix model with a statistically homogeneous distribution of diagonal disorder and uncorrelated off-diagonal terms can host a multifractal phase.
A CASE SERIES OF INTRACARDIAC THROMBOSIS REVEALING BEHCETS DISEASE IN MOROCCAN PATIENTS
Authors:   Department of Internal Medicine, Faculty of Medicine and Pharmacy of Agadir, University Ibn Zohr, Agadir, Morocco., Boustani Salma , Elkaddouri Oumaima ,   Department of Internal Medicine, Faculty of Medicine and Pharmacy of Agadir, University Ibn Zohr, Agadir, Morocco., Bouissar Wassila ,   Department of Internal Medicine, Faculty of Medicine and Pharmacy of Agadir, University Ibn Zohr, Agadir, Morocco.
Published: January 2024

Aim of the work: The clinical presentation of Behcets disease (BD) is varied, While cardiovascular effects such as pericarditis, acute myocardial infarction, conduction disorders, and valvular disease have been reported, they are infrequent. The formation of intracardiac thrombus, as seen in our patients, is an exceptional occurrence. Patients and methods: We present a retrospective study of 4 cases of intracardiac thromboses in a series of 50 patients followed for BD in our department (over a period of four years), The diagnosis is made on the basis of the criteria proposed by the International Study Group (ISG). Results: All were male, the mean age at the time of the ICT diagnosis was 29.5 years. The main presenting symptoms were hemoptysis, chest pain, and dyspnea. It was associated with pulmonary artery aneurysm in two cases, and pulmonary embolism in all cases. In three cases, echocardiography was sufficient to reach the diagnosis but, in one, the difficulty of differential diagnosis with a cardiac tumor has been raised. The diagnosis has been confirmed by examining the operative specimen histologically in the case of this deceased patient, who experienced postoperative complications. Three patients were treated with immunosuppressant agents, corticosteroids, and anti-TNF alpha, one of whom showed a good response to treatment. Conclusion: A potential diagnosis of BD should be considered if a patient presents with an intracardiac mass, this is especially relevant in young male patients.
DERMATOMYOSITIS UNMASKING HIDDEN BREAST CARCINOMA: A CASE REPORT
Authors:   Final Year Postgraduate, Department of DVL, Narayana Medical College, Nellore 524003., G.R Heera , Kiran Raja Uday ,   Assistant Professor, Department of DVL, Narayana Medical College, Nellore 524003., Rathi Pooja ,   Final Year Postgraduate, Department of DVL, Narayana Medical College, Nellore 524003., Vijaya Mohan Rao A. ,   Professor and Head of Department, Department of DVL, Narayana Medical College, Nellore 524003.
Published: January 2024

Dermatomyositis is a rare autoimmune disorder characterized by muscle weakness and skin abnormalities. It is associated with malignancy in 15 to 30% of cases. We present the case of a 73-year-old female patient who initially presented with itchy purplish skin lesions, photosensitivity and oral ulcers. The patient also complained of difficulty in standing, joint pain of the shoulders, knees and ankles, but no joint swelling or morning stiffness. Relevant investigations revealed a surprising discovery of underlying left breast carcinoma, which was asymptomatic. This case highlights the importance of recognizing dermatomyositis as a paraneoplastic syndrome and its potential to unmask hidden malignancies. Dermatomyositis has long been recognized as a paraneoplastic syndrome, meaning that it can precede the clinical manifestation of an underlying malignancy. In this case, the patients initial presentation with dermatomyositis-related skin and muscle symptoms served as a sentinel sign, alerting clinicians to investigate further. The patient responded positively to treatment with intravenous methylprednisolone and was subsequently referred for further management of the breast carcinoma.
VULVAR SQUAMOUS CELL CARCINOMA REVEALED BY PRURITUS
Authors:   Dermatology Department of the University Hospital of Tangier, Tetouan, Al-Hoceima, Faculty of Medicine and Pharmacy of Tangier, Abdelmalek Essaadi University., Marraha S. , Jouari O.El ,   Dermatology Department of the University Hospital of Tangier, Tetouan, Al-Hoceima, Faculty of Medicine and Pharmacy of Tangier, Abdelmalek Essaadi University., Farhat L. ,   Dermatology Department of the University Hospital of Tangier, Tetouan, Al-Hoceima, Faculty of Medicine and Pharmacy of Tangier, Abdelmalek Essaadi University., El Ali FZ. ,   Dermatology Department of the University Hospital of Tangier, Tetouan, Al-Hoceima, Faculty of Medicine and Pharmacy of Tangier, Abdelmalek Essaadi University., Handous N. ,   Dermatology Department of the University Hospital of Tangier, Tetouan, Al-Hoceima, Faculty of Medicine and Pharmacy of Tangier, Abdelmalek Essaadi University., Gallouj S. ,   Dermatology Department of the University Hospital of Tangier, Tetouan, Al-Hoceima, Faculty of Medicine and Pharmacy of Tangier, Abdelmalek Essaadi University.
Published: January 2024

Squamous cell carcinoma of the vulva accounts for 3 to 5% of all female genital cancers. It occurs in women with a history of HPV infection or lichen sclerosus lesions, and in post-menopausal women is also linked to estrogen deficiency. It is generally manifested by a painful, pruritic ulceration on an erythroplastic background on the inner surface of the labia majora. Diagnosis is confirmed by biopsy with anatomical and histological examination. Diagnosis must be made early, and treatment relies mainly on surgery. We report the case of a post-menopausal woman with no pathological history who consulted us for a single symptom: vaginal pruritus.
EXPERIMENTAL STUDY OF NATURAL CONVECTION IN A SOLAR CHIMNEY WITH HYPERBOLIC COLLECTOR
Authors:   University of Agadez, PO BOX 199, Niger., Ousmane Moctar ,   Laboratory L.E.T.R.E, Universite Joseph KI-ZERBO, Burkina Faso., Sikoudouin Maurice K.Y Thierry ,   Laboratory L.E.T.R.E, Universite Joseph KI-ZERBO, Burkina Faso., Kabore Boureima ,   Departement de Physique, UFR-ST, Universite Norbert ZONGO, Burkina Faso.,   Laboratory L.E.T.R.E, Universite Joseph KI-ZERBO, Burkina Faso., Magloire Pakouzou B. ,   Laboratory L.E.T.R.E, Universite Joseph KI-ZERBO, Burkina Faso.,   Universite de Bangui, R.C.A., Ouedraogo Salifou ,   Laboratory L.E.T.R.E, Universite Joseph KI-ZERBO, Burkina Faso., Wende Pouire Ouedraogo Germain ,   Laboratory L.E.T.R.E, Universite Joseph KI-ZERBO, Burkina Faso.,   ESI, Universite de Fada NGourma, Burkina Faso., Boureima Dianda ,   Laboratory L.E.T.R.E, Universite Joseph KI-ZERBO, Burkina Faso.,   Institut de Recherche en Sciences Appliquees et Technologies, Burkina Faso., Sie Kam ,   Laboratory L.E.T.R.E, Universite Joseph KI-ZERBO, Burkina Faso., Joseph Bathiebo Dieudonne ,   Laboratory L.E.T.R.E, Universite Joseph KI-ZERBO, Burkina Faso.
Published: January 2024

The solar tower consisting of the chimney, the turbine, and the collector, initiated by Jorg Schlaich, is an electrical energy production system. This work aims to understand the phenomenon of natural air convection in the device as a function of solar radiation. A prototype designed at the L.E.T.RE laboratory made it possible to experimentally study the behavior of air in the device. To do this, we carried out readings on the solar tower using measuring devices such as the Midi LOGGER, the pyranometer and the hot wire anemometer. They showed that the air temperature changes depending on the amount of sunlight as well as the speed of the fluid entering the chimney. The temperature of the absorber is maximum between 12:30 p.m. to 1 p.m. with values Ã¢Â€Â‹Ã¢Â€Â‹respectively of 87.1Ã‚Â°C 88.5Ã‚Â°C and 91.3Ã‚Â°C for the days of October 8, October 9, and November 9, 2022. However, the temperature of the fluid drops from the collector to the chimney. The results show that the collector efficiency reaches 19.32% on average 34.05% and 33.49% respectively for the days of 08/10/2022, 09/10/2022 and 09/11/2022. The collector is insulated using polystyrene. With improvements the system could meet the needs for ventilation by thermal draft, drying as well as electricity production.
The Role of External Auditor in the Adoption of Computer-Assisted Audit Techniques with Unified Theory of Acceptance and Use of Technology: An Empirical Study in Public Audit Firms in Jakarta
Authors: Deniswara Kevin , Henky Thomas , Mulyawan Archie Nathanael , Armand Wishnu Kameshwara , Mustapha Mazlina
Published: January 2024

The research aimed to analyze factors that influence acceptance of Computer Assisted Audit Techniques (CAATs) among external auditors in Public Audit Firms in Jakarta. The Unified Theory of Acceptance and Use of Technology (UTAUT) approach was used for this analysis. Technological advancements had an effect on auditors' ability to adopt audit software. However, it had been found that there was no preparation or openness from auditors, leading to suboptimal utilization of audit implementation software and affected the presentation of audit information. This investigation adopted a quantitative method by distributing close-ended questionnaires to external auditors in audit firms in Jakarta. Data were analyzed using Partial Least Square with SmartPLS Ver 3. The results show that social influence affected behavioral intention of external auditors in Jakarta in adopting and using CAATs. Expectancy performance, effort expectancy, and facilitating conditions do not affect behavioral intention of external auditors in adopting and using CAATs. The research generates contributions that can be further directed toward the development of auditors’ competencies in optimizing technology in audit.
A fuzzy TOPSIS-based approach for prioritizing low-impact development methods in high-density residential areas
Authors: Mehri Milad , Sadeghi Sonia , Mehdy Hashemy Shahdany Seied
Published: January 2024

The study successfully implemented six low-impact development (LID) methods to manage surface runoff in urban areas: green roof, infiltration trench, bio retention cell, rain barrel, green roof combined with infiltration trench, and rain barrel combined with bio-retention cell. Each method has unique benefits in mitigating surface runoff effects in urban environments. The following four indicators were used to evaluate the methods: runoff volume reduction, peak runoff flow rate reduction, economic sustainability, and social sustainability. The study, which lasted approximately 4 months, was conducted in an eastern Tehran metropolis residential area with a mix of old and new buildings. The SWMM model determined runoff volume and peak flow values, and a price analysis list determined the economic index. Local experts completed 25 questionnaires to evaluate the social index. Fuzzy TOPSIS multi-indicator decision criteria were used to prioritize LID methods, and the Rain barrel + Bio retention cell combined scenario emerged as the best option based on all four criteria. The method reduced peak runoff flow by 23.1–66.1% under rainfall with 10-year return periods. The green roof + infiltration trench method had the highest percentage reduction of 2,737 m3, while the infiltration trench had the lowest reduction of 273 m3.
POLICY ANALYSIS OF EU COUNTRIES UNDER THE CARBON EMISSIONS TRADING SYSTEM
Authors: Zhenlian T. , Solovieva Y. V.
Published: January 2024

The carbon tariff policy of the EU seeks to lessen emissions and promote the use of renewable energy sources. EU member states primarily undertake a number of fiscal and tax policy measures, such as taxation and preferential tax policies, government procurement policies, and financial subsidy policies, in relation to the carbon emissions trading system. to promote the creation, use, and development of renewable energy. Thе article does multiple linear regression analysis on the variables carbon emission intensity and per capita energy consumption, industrial production index, and per capita GDP based on pertinent data from 8 nations in the European Union from 2013 to 2019. The financial subsidies, green procurement regulations, and tax laws of EU nations participating in the carbon emissions trading system are examined in detail based on the findings, offering other nations useful real-world experience.
DISEÑO DE UN ANÁLISIS MULTICRITERIO PARA ESTIMAR EL POTENCIAL ECOTURÍSTICO DE LA RESERVA PAISAJÍSTICA SUBCUENCA DEL COTAHUASI, AREQUIPA, PERÚ
Authors: Canales-Springett Ayling Wetzell , Chávez Salas Jorge Mario
Published: January 2024

El ecoturismo es una actividad que puede contribuir de diversas formas al desarrollo sostenible y a la conservación de la biodiversidad en zonas con potencial ecoturístico, en especial en ámbitos rurales y silvestres, por lo que desarrollar metodologías para estimar el potencial ecoturístico de un espacio debería consignar dichos principios, contribuyendo así a la planificación y gestión apropiada de estas áreas. Esta investigación tuvo como objetivo diseñar una metodología de análisis de factores con un enfoque multicriterio de conservación y desarrollo sostenible, jerarquización turística, educación ambiental, monitoreo participativo y sistemas social-ecológicos, descritos y desarrollados por investigadores de nivel internacional, entidades académicas, institutos de desarrollo y organizaciones gubernamentales y no gubernamentales. Se definieron trece criterios de evaluación, de los cuales siete tienen un enfoque ambiental, biológico y sociocultural y los otros seis, un enfoque de planificación, servicios y mercado. Al mismo tiempo se establecieron cinco niveles de jerarquía y puntajes, desde un nivel bajo de potencial ecoturístico, hasta uno muy alto o excepcional, encaminados a la estimación del potencial ecoturístico. Esta metodología fue aplicada a la Reserva Paisajística Subcuenca del Cotahuasi, en el departamento de Arequipa, Perú, lo que permitió evaluar, de forma detallada y a la vez integral, el potencial ecoturístico de esta área natural protegida, obteniéndose como resultado un potencial para el desarrollo del ecoturismo de nivel Bueno, mostrando además qué condiciones requieren ser mejoradas.
Drug-Protein Interactions Prediction Models Using Feature Selection and Classification Techniques
Authors: Idhaya T. , Suruliandi A. , Raja S. P.
Published: January 2024

Background::

Drug-Protein Interaction (DPI) identification is crucial in drug discovery. The high dimensionality of drug and protein features poses challenges for accurate interaction prediction, necessitating the use of computational techniques. Docking-based methods rely on 3D structures, while ligand-based methods have limitations such as reliance on known ligands and neglecting protein structure. Therefore, the preferred approach is the chemogenomics-based approach using machine learning, which considers both drug and protein characteristics for DPI prediction.

Methods::

In machine learning, feature selection plays a vital role in improving model performance, reducing overfitting, enhancing interpretability, and making the learning process more efficient. It helps extract meaningful patterns from drug and protein data while eliminating irrelevant or redundant information, resulting in more effective machine-learning models. On the other hand, classification is of great importance as it enables pattern recognition, decision-making, predictive modeling, anomaly detection, data exploration, and automation. It empowers machines to make accurate predictions and facilitates efficient decision-making in DPI pre-diction. For this research work, protein data was sourced from the KEGG database, while drug data was obtained from the DrugBank data machine-learning base.

Results::

To address the issue of imbalanced Drug Protein Pairs (DPP), different balancing techniques like Random Over Sampling (ROS), Synthetic Minority Over-sampling Technique (SMOTE), and Adaptive SMOTE were employed. Given the large number of features associated with drugs and proteins, feature selection becomes necessary. Various feature selection methods were evaluated: Correlation, Information Gain (IG), Chi-Square (CS), and Relief. Multiple classification methods, including Support Vector Machines (SVM), Random Forest (RF), Adaboost, and Logistic Regression (LR), were used to predict DPI. Finally, this research identifies the best balancing, feature selection, and classification methods for accurate DPI prediction.

Conclusion::

This comprehensive approach aims to overcome the limitations of existing methods and provide more reliable and efficient predictions in drug-protein interaction studies.
Identification of Novel CDK 4/6 Inhibitors by High-throughput Virtual Screening
Authors: Debnath Abhijit , Mazumder Rupa
Published: January 2024

Background:

CDK4/6 plays a crucial role in regulating cell proliferation, and inhibiting
this kinase can effectively prevent the initiation of cell growth and division. However, current FDAapproved
CDK4/6 inhibitors have limitations such as poor bioavailability, adverse effects, high cost,
and limited accessibility. Thus, this research aimed to discover novel CDK4/6 inhibitors to overcome
the challenges associated with FDA-approved inhibitors.

Methods:

To identify potential CDK4/6 inhibitors, we have performed structure-based virtual
screening. Chem-space and Mcule databases have been screened, followed by a series of filtering
steps. These steps included assessing drug-likeness, PAINS alert, synthetic accessibility scores,
ADMET properties, consensus molecular docking, and performing molecular dynamics simulations.

Results:

Four new compounds (CSC089414133, CSC091186116, CSC096023304, CSC101755872)
have been identified as potential CDK4/6 inhibitors. These compounds exhibited strong binding
affinity with CDK4/6, possessed drug-like features, showed no PAINS alert, had a low synthetic
accessibility score, demonstrated effective ADMET properties, were non-toxic, and exhibited high
stability.

Conclusion:

Inhibiting CDK4/6 with the identified compounds may lead to reduced cell proliferation
and the promotion of cancer cell death.
Anti-seizure Medications: Challenges and Opportunities
Authors: Tandon Neha , Radosavljevic Milica , Vucevic Danijela , Radenkovic Miroslav , Jancic Jasna , Samardzic Janko
Published: January 2024

Epilepsy is a chronic neurological condition characterized by unprovoked, recurrent seizures.
There are several types of epilepsy, and the cause of the condition can vary. Some cases of
epilepsy have a genetic component, while others may be caused by brain injuries, infections, or other
underlying conditions. Treatment for epilepsy typically involves anti-seizure medications
(ASMs), although different approaches, such as surgery or a special diet, may be considered in specific
cases. The treatment aims to effectively manage and potentially eliminate seizures while minimizing
any accompanying side effects. Many different ASMs are available, and the choice of medication
depends on several factors, including the type of seizures, the patient's age, general health,
and potential drug interactions. For the treatment of epilepsy, there have been significant advancements
in recent decades, which have led to the approval of many different ASMs. Newer ASMs offer
a broader range of mechanisms of action, improved tolerability profiles, and reduced drug interactions
compared to older drugs. This review aims to discuss the pharmacological characteristics,
clinical applications, effectiveness, and safety of ASMs, with a particular emphasis on various age
groups, especially children. Moreover, this review seeks to provide a comprehensive understanding
of ASM therapy for epilepsy management, assisting physicians in selecting suitable ASMs for their
patients.
Sufficiency of a Single Negative Thyroglobulin Standard for Judging the
Success of Ablation in Low- and Intermediate-risk Differentiated Thyroid
Cancer: A Retrospective Study
Authors: Long Yahong , Jin Jianhua , Zhang Wanchun
Published: January 2024

Background:

We investigated how reduced successful ablation criteria may be used
to evaluate radioiodine remnant ablation in patients with low- and intermediate-differentiated
thyroid carcinoma (DTC).

Methods:

Overall, 254 low- and intermediate-risk patients with DTC were categorized into
three groups (positive, weak, positive, and negative) on the basis of a visual study of thyroid
imaging performed before postoperative iodine treatment. Semi-quantitative analysis parameters
were incorporated into the positive Tc-99m pertechnetate scanning to further examine the clinical
use of thyroid imaging. We investigated the value of successful judgment criteria and the
influencing factors of radioiodine ablation. At the same time, the predictive value of thyroglobulin
(Tg) for radioiodine treatment and the overall clinical efficacy were assessed.

Results:

A total of 250 (98.43%) patients were identified as having functional thyroid tissue
residue on the Rx-whole-body scan, and 137 (53.94%) patients had positive Tc-99m pertechnetate
scans using semi-quantitative analysis. The single Tg standard could not substitute the double
standard (χ2c=22.042, p< 0.001) for patients with residual thyroid weight by a semiquantitative
analysis. However, the semi-quantitative analysis revealed no association between
99mTcO4−thyroid scan and ablation treatment using semi-quantitative analysis; only preablation
sTg levels were related with success in the multivariate logistic regression analysis,
with a cut-off value of 2.88 ng/mL. The pre-ablation stimulated Tg level was also the primary
factor of satisfactory response following follow-up with an optimal cut-off of 6.506 ng/mL.

Conclusion:

Even in low- and intermediate-risk patients with DTC, a single negative Tg standard
also requires receiving some restrictions in the evaluation of ablation success and is inadequate.
Conventional 99mTcO4 thyroid imaging combined with a quantitative analysis program
can improve the clinical practice of single negative Tg standard.
Designing a Secretory form of RTX-A as an Anticancer Toxin: An
In Silico Approach
Authors: Taheri-Anganeh Mortaza , Nezafat Navid , Gharibi Saba , Khatami Seyyed Hossein , Vahedi Farzaneh , Shabaninejad Zahra , Asadi Marzieh , Savardashtaki Amir , Movahedpour Ahmad , Ghasemi Hassan
Published: January 2024

Background:

Cancer is a leading cause of death and a significant public health
issue worldwide. Standard treatment methods such as chemotherapy, radiotherapy, and
surgery are only sometimes effective. Therefore, new therapeutic approaches are needed
for cancer treatment. Sea anemone actinoporins are pore-forming toxins (PFTs) with
membranolytic activities. RTX-A is a type of PFT that interacts with membrane phospholipids,
resulting in pore formation. The synthesis of recombinant proteins in a secretory
form has several advantages, including protein solubility and easy purification. In this
study, we aimed to discover suitable signal peptides for producing RTX-A in Bacillus
subtilis in a secretory form.

Methods:

Signal peptides were selected from the Signal Peptide Web Server. The probability
and secretion pathways of the selected signal peptides were evaluated using the
SignalP server. ProtParam and Protein-sol were used to predict the physico-chemical
properties and solubility. AlgPred was used to predict the allergenicity of RTX-A linked
to suitable signal peptides. Non-allergenic, stable, and soluble signal peptides fused to
proteins were chosen, and their secondary and tertiary structures were predicted using
GOR IV and I-TASSER, respectively. The PROCHECK server performed the validation
of 3D structures.

Results:

According to bioinformatics analysis, the fusion forms of OSMY_ECOLI and
MALE_ECOLI linked to RTX-A were identified as suitable signal peptides. The final
proteins with signal peptides were stable, soluble, and non-allergenic for the human body.
Moreover, they had appropriate secondary and tertiary structures.

Conclusion:

The signal above peptides appears ideal for rationalizing secretory and soluble
RTX-A. Therefore, the signal peptides found in this study should be further investigated
through experimental researches and patents.
Revolutionizing Nitrofurantoin Delivery: Unraveling Challenges and
Pioneering Solutions for Enhanced Efficacy in UTI Treatment
Authors: Nanda Gouri P. , Patel Mrunali , Patel Rashmin B.
Published: January 2024

Nitrofurantoin is an antimicrobial drug, highly effective in the treatment of critical or chronic bacterial infections of the urinary tract, and hence, it is the first line choice of drug for the treatment of urinary tract infections (UTI). Although the molecule is legacy in nature, there are many challenges in terms of drug product formulation and efficacy thereof. The authors are main-ly focused in this literature review on, but not limited to, understanding the molecule in terms of physico-chemical properties of the drug, pharmacokinetics and pharmacodynamics, approved and withdrawn formulations, challenges concerning drug formulation, the cause of drug shortage in the market, improvement areas in terms of formulation and its therapeutic effectiveness. The au-thors found during their widespread review that the major challenge in the existing conventional drug delivery system of nitrofurantoin is the fluctuation of plasma concentration owing to its var-iability in drug absorption. Further, they understood that the variability in absorption is due to in-herent variability in particle size distribution. Based on the findings, authors also explored the possibilities to deliver the drug in novel drug delivery systems such as nano self-emulsifying emulsions, nanoemulsions and multiple emulsions where the drug can be presented in soluble form and hence the variability in absorption and fluctuation in plasma concentration of drug can be avoided and described briefly the salient features of each drug delivery in this review.
Public Health Dashboards in Overdose Prevention: The Rhode Island Approach to Public Health Data Literacy, Partnerships, and Action
Authors: Yedinak Jesse , Krieger Maxwell S , Joseph Raynald , Levin Stacey , Edwards Sarah , Bailer Dennis A , Goyer Jonathan , Daley Ndoye Colleen , Schultz Cathy , Koziol Jennifer , Elmaleh Rachael , Hallowell Benjamin D , Hampson Todd , Duong Ellen , Shihipar Abdullah , Goedel William C , Marshall Brandon DL
Published: January 2024

As the field of public health rises to the demands of real-time surveillance and rapid data-sharing needs in a postpandemic world, it is time to examine our approaches to the dissemination and accessibility of such data. Distinct challenges exist when working to develop a shared public health language and narratives based on data. It requires that we assess our understanding of public health data literacy, revisit our approach to communication and engagement, and continuously evaluate our impact and relevance. Key stakeholders and cocreators are critical to this process and include people with lived experience, community organizations, governmental partners, and research institutions. In this viewpoint paper, we offer an instructive approach to the tools we used, assessed, and adapted across 3 unique overdose data dashboard projects in Rhode Island, United States. We are calling this model the “Rhode Island Approach to Public Health Data Literacy, Partnerships, and Action.” This approach reflects the iterative lessons learned about the improvement of data dashboards through collaboration and strong partnerships across community members, state agencies, and an academic research team. We will highlight key tools and approaches that are accessible and engaging and allow developers and stakeholders to self-assess their goals for their data dashboards and evaluate engagement with these tools by their desired audiences and users.
Assessment of renal and cardiovascular risks in patients with type 2 diabetes when using non-steroidal mineralocorticoid receptor antagonists
Authors: Yerokhovych V.М. , Komisarenko Y.I. , Karpenko O.V. , Pankiv V.I. , Kobyliak N.M. , Bobryk M.I. , Kyriienko D.V. , Gurska K.S. , Kaplina A.A. , Vasiuk V.L.
Published: January 2024

Background. Given the proven excessive activation of the renin-angiotensin-aldosterone system and the clinical manifestations of hypertension, mostly of renal origin, there is a need to optimize antihypertensive therapy aimed at an active nephroprotection. The purpose of the study is to carry out a comprehensive assessment of kidney and heart risk factors in patients with type 2 diabetes mellitus and chronic kidney disease (CKD) and to justify the administration of non-steroidal mineralocorticoid receptor antagonists to these patients. Materials and methods. In a prospective cohort study, 88 patients with type 2 diabetes were examined: group 1 — estimated glomerular filtration rate (eGFR) < 60 ml/min/m2, group 2 — eGFR ≥ 60 ml/min/m2. eGFR was evaluated according to the CKD-EPI (Chronic Kidney Disease Epidemiology Colla­boration) formula based on serum creatinine. GFR category was defined according to the KDIGO (Kidney Disease: Improving Global Outcomes) criteria. The albumin-creatinine ratio was calcula­ted. The level of glycated hemoglobin (HbA1c) was assessed by the method of high-performance liquid chromatography. Aldosterone was evaluated by immunoenzymatic method. Results. In patients with eGFR < 60 ml/min/m2, the albumin-creatinine ratio in daily urine is statistically significantly higher compared to group 2. Patients with eGFR < 60 ml/min/m2 had an average uric acid level of 410.3 ± 98.8 μmol/l, which is statistically significantly higher than in those with eGFR ≥ 60 ml/min/m2 — 321.10 ± 74.54 μmol/l. A statistically significant correlation between the level of uric acid and markers of renal dysfunction was found only in patients with eGFR < 60 ml/min/m2. Aldosterone levels were higher in the first group. No statistical difference was found between the average value of HbA1c in the studied groups. Conclusions. Numerous factors of unfavorable prognosis regarding kidney and heart risks have been identified: hypertension, increased albumin-creatinine ratio and cholesterol, unsatisfactory compensation of diabetes, obesity. There is an increase in the frequency of resistant hypertension, hyperuricemia, and hyperaldosteronism in patients with decreased eGFR. In patients with diabetic kidney damage on the background of type 2 diabetes, the administration of finerenone, a non-steroidal mine­ralocorticoid receptor antagonist, at a dose of 10–20 mg/day is pathogenetically justified.
Understanding Intersectionality through Tequila Leila’s Experience in 10 Minutes 38 Seconds in this Strange World (2019)
Authors: Wandira Diah Putri Ayu , Datau Rizal Octofianto , Wulan Nur
Published: January 2024

The article aims to explore intersectionality and its societal impact on the characters as portrayed in Elif Shafak’s 10 Minutes 38 Seconds In This Strange World (2019). This issue was extensively discussed to comprehend the representation of gender inequality and patriarchy in the story. Although the text has been the subject of discussion among a limited number of scholars, the novelty of this study lies in its adoption of a theoretical perspective that has not been utilized previously, specifically Kimberly Crenshaw’s framework of intersectionality. Methodologically, this qualitative study identified and collected the primary data from the text by selecting direct and indirect quotations relevant to the issue discussed. This approach was complemented by secondary sources from previous and related studies which were drawn from books and journal articles. Having analyzed the text by applying Crenshaw’s theory of intersectionality, the authors found that Shafak represented gender inequality and patriarchy in Turkey as a hegemonic and systematic belief. The text also discovered that the perpetuation of the patriarchal system, rooted in the practices frequently justified by religious rhetoric, is effectively prolonged by the continued male dominance in shaping public policies. It also indicates that the main character, Tequila Leila, and the other characters in the story possess overlapping identities, leading to numerous unfortunate experiences. Tequila Leila’s oppressed experiences unveiled the structural and representational intersectionalities.
Das análises de gêneros textuais/discursivos às propostas didáticas: entrevista com Joaquim Dolz
Authors: Cobucci Paula , Dolz Joaquim , Aparecido da Silva Kleber
Published: January 2024

Esta entrevista tem por objetivo central apresentar reflexões desde as análises de gêneros textuais/discursivos às propostas didáticas, focalizando, entre outros, temas como a importância do trabalho em sala de aula com gêneros textuais/discursivos para a formação de cidadãos capazes de agir socialmente, demandando seus direitos, expondo seus pensamentos e desejos. O texto nos convida a uma “crítica de dentro para fora”, por meio da seguinte provocação e/ou indagação: “Como empoderar o professor de Língua Portuguesa para ensinar de forma produtiva gêneros textuais e (trans)formar cidadãos brasileiros por meio de uma educação linguística crítica?”. A partir de uma entrevista feita via plataforma Zoom e de trocas de e-mails com o pioneiro e estudioso da área da Didáticas das Línguas, Joaquim Dolz, da Universidade de Genebra, visam-se suscitar reflexões críticas sobre planejamentos e experiências docentes em sala de aula, (re)apresentar realidades do ensino de gêneros textuais/discursivos em Língua Portuguesa e desvendar possibilidades metodológicas e teóricas profícuas para a rupturas de concepções cristalizadas no sistema de ensino público brasileiro.
Testagem de proficiência em língua inglesa no formato de curso online: uma análise de gênero
Authors: Buzetto Bruno Souza , Marcuzzo Patrícia
Published: January 2024

As análises de gêneros discursivos têm sido desenvolvidas a partir de diferentes aparatos teórico-metodológicos que buscam dar conta dos aspectos linguísticos, sociais e retóricos levantados ao se pensar em gêneros. A Análise Crítica de Gênero (ACG) (MOTTA-ROTH, 2005, 2008a, 2008b; MOTTA-ROTH; HEBERLE, 2015), por exemplo, é uma perspectiva que propõe uma análise de gêneros fundamentada em três abordagens, a saber, Sociorretórica (BATHIA, 1993; MILLER, 1984; BAZERMAN, 1988; SWALES, 1990; 1998; 2004), Linguística Sistêmico-Funcional (LSF) (HALLIDAY & HASAN, 1989; HALLIDAY, 1994; HALLIDAY & MATTHIESSEN, 2004; 2014) e Análise Crítica do Discurso (ACD) (FAIRCLOUGH, 1989; 1995; 2010). Nesse sentido, este artigo tem por objetivo reportar a análise que partiu dos pressupostos teórico-metodológicos da ACG para investigar o curso de proficiência em inglês online da Universidade Franciscana (UFN), uma Instituição de Ensino Superior (IES) localizada no município de Santa Maria, no Rio Grande do Sul. O processo de testagem de proficiência da UFN carece de investigação devido ao fato de que o curso online surgiu recentemente, como resposta às restrições impostas pela pandemia de COVID-19, que suspendeu diversas atividades presenciais. A partir de metodologias de análise baseadas na ACG, investigamos três aspectos do curso: sua estrutura, os textos-base e as questões que fazem parte do processo de testagem. Os resultados deste estudo não apenas lançam luz a aspectos linguísticos e estruturais de um gênero relativamente novo, como também contribuem para o avanço das análises de gêneros ao partir de uma perspectiva teórico-metodológica que preza por uma abordagem interdisciplinar, detalhada e problematizadora.
Resenha do livro “O gênero como ele é (e como não é)”, de Benedito Gomes Bezerra
Authors: Santos Pereira Maria Ladjane dos
Published: January 2024

Para que esta resenha possa ser lida por você, leitor deste periódico, aponto para um dos caros conceitos explorados na obra de Bezerra (2022), o uptake. Valho-me, portanto, da metáfora de Freadman (1994), ao considerar a chamada de submissão da revista como o lançamento da bola que deu início ao jogo. Em resposta, envio o texto que, dentro das regras do jogo, se apresenta ao público como parte do conteúdo desta edição. É nesta direção, de uma concepção de gêneros para além de definições centradas em um ou outro aspecto de natureza mais estrutural ou composicional que caminha a obra em destaque.Neste livro, o autor apresenta os gêneros considerando a sua complexidade e, consequentemente, dá conta de explorar as relações contextuais para a compreensão desse objeto. Em seus termos, “o gênero é complexo como a linguagem é complexa, como os seres humanos que a constituem e por ela são constituídos são complexos” (p. 18).
Uma proposição metodológica para a análise de gêneros acadêmicos à luz de culturas disciplinares
Authors: Sousa Aline Pereira , Bernardino Cibele Gadelha
Published: January 2024

Sob o viés da abordagem sociorretórica de gêneros, neste artigo, temos o intuito de apresentar um construto metodológico para a análise de gêneros acadêmicos à luz da compreensão de culturas disciplinares. Para tanto, revisitamos e dialogamos com algumas propostas analíticas já reconhecidas no campo teórico a fim de justificar como tais abordagens influenciaram a construção do nosso próprio desenho metodológico (Swales, 1990, 2004; Bhatia, 1993; Hyland, 2000; Askehave; Swales, 2001). Em seguida, evidenciamos a conceituação de cultura disciplinar (Pacheco; Bernardino, 2022) que está por trás do nosso percurso metodológico e que vem se tornando produtiva à análise de gêneros acadêmicos. Por fim, refletimos sobre as dificuldades de operacionalização e implicações desta metodologia para a viabilização de pesquisas empíricas na área. De modo geral, acreditamos que nossa proposição analítica possa vir a contribuir para uma descrição de gêneros acadêmicos cada vez mais pautada no olhar da própria cultura disciplinar que o produz.
O uso de gêneros textuais nas atividades laborais de pecuaristas
Authors: Viana Fonseca Alyssandra , De Oliveira Paz Ana Maria
Published: January 2024

Os textos estão presentes em todas as atividades de trabalho inclusive naquelas que demandam, prioritariamente, esforços físicos e braçais como é o caso dos pecuaristas. Entretanto, como as publicações acadêmicas que discutem suas atividades são voltadas, na maioria das ocorrências, para questões que envolvem o manejo dos animais para abate e produção leiteira, o uso de gêneros textuais, por esses trabalhadores não é evidenciado. Diante dessa problemática, o presente artigo objetiva analisar textos que direta e indiretamente são utilizados por pecuaristas no trato de bovinos, à luz do Interacionismo Sociodiscursivo. Para tanto, utiliza como aportes teóricos Marcuschi (2008; 2010) em relação aos gêneros textuais e Bronckart (1999) no que diz respeito às categorias de análise destes em relação as condições de produção. Como resultados, observamos a importância e a necessidade das práticas de leitura e escrita nesse espaço de trabalho para obtenção de resultados positivos em determinadas demandas e tarefas, assim como a presença, nos gêneros analisados, de características que são específicas dos usos dos produtores e da comunidade na qual estão inseridos.
¿Por qué es necesario eliminar la categoría sexo del ámbito biomédico? Hacia la noción de bioprocesos en la era posgenómica
Authors: Ciccia Lu
Published: January 2024

La categoría sexo suele remitir a la idea de variables pre-sociales, es decir, desvinculadas del ambiente. Al mismo tiempo, se las interpreta fundamentales para acceder a una mejor comprensión respecto de las prevalencias, el desarrollo y el tratamiento de enfermedades. En este trabajo, argumento que tal caracterización supone una serie de sesgos que derivan de una lectura mecanicista sobre los procesos de diferenciación sexual, por un lado, la enfermedad, por otro y de manera confluente, respecto de la relación sexo-prevalencia. Con dicho fin, mostraré que ni la mayoría de las variables consideradas de relevancia clínica, ni sus variabilidades, son definidas por los atributos que asociamos a la categoría sexo. Por eso propondré que en la era posgenómica resulta necesario desplazar dicha categoría por la noción de bioprocesos. Este desplazamiento sugiere que la plasticidad que nos caracteriza desde la ontogenia deja sin efecto la dicotomía sexo-género, puesto que resulta implausible rastrear atributos biológicos pre-sociales, sobre los que finalmente cobraría inteligibilidad la propia noción de sexo. Posteriormente, recuperaré la idea de clases prácticas para considerar que, combinándola con la noción de bioprocesos, las variables biomédicas deben ser situadas y específicas, ajustadas al estudio de interés. Mostraré que algunas de las implicancias del desplazamiento que propongo suponen diluir valores cisnormativos, que marginalizan las corporalidades trans.
Relatos trans*: [re]-torciendo los contratos narrativos en el cine documental
Authors: Lapuerta Kani
Published: January 2024

"Relatos trans* [re]-torciendo los contratos narrativos en el cine documental" ofrece una perspectiva crítica y creativa de las construcciones narrativas alrededor de lo trans y de las disidencias sexogenéricas. Este ensayo es una búsqueda y un diálogo con varias propuestas narrativas con el fin de trazar posibles rutas alternativas para la construcción de relatos trans. Basándose en el trabajo de una amplia gama de pensadorxs, academicxs y narradorxs feministas, transfeministas y de los estudios culturales se genera una reflexión acerca de las narrativas y narratologías trans.
PEOPLES STUDIES AND NATIONAL POLICY IN THE SOVIET ERA
Authors: Martynova Marina , Tishkov Valery
Published: January 2024

The article presents the results of a study devoted to the analysis of the interaction of ethnic studies (ethnology, or, rather, ethnography as it was called at the time) and Soviet nationality policy. The study of the role of domestic ethnography in the history of the country, reviewing the development of science in the context of the state strategy for the development of society is based on the analysis of a variety of subjects related to the ‘national question’. The project, supported by the Russian Foundation for Basic Research and the Russian Historical Society as part of the competition ‘The Soviet Era: History and Legacy (to the 100th anniversary of the USSR)’, addresses a number of research questions, providing a basis for identifying the role of academic developments and the creative elite in the national policy. The work is largely of historiographical nature. The authors focus on the analysis of conceptual approaches, on the quests and achievements of Russian ethnography in the 20th century. The authors characterize the research tools and provide a comprehensive overview of scientific ethnographic trends that were developed in different parts of the country in the Soviet period from the perspective of national policy. The past allows one to speak of the importance of an individual, an expedition, an (arti)fact in the full range of issues under study. By reading the ‘bright and dark’ pages of the history of science, one can better understand the reality that underlies today’s ethnological research. Compared to the Soviet concept of nation-building, we may clearer see the potential of ethnology and the promise of its role in contemporary Russia for shaping Russian identity, developing mechanisms for migration policy, adapting children of migrants, etc.