bluuebunny/crossref_metadata_2025 huggingface dataset:
ЕНДОМЕТРІОЗАСОЦІЙОВАНА ХІРУРГІЯ: ВПЛИВ ЛАПАРОСКОПІЧНИХ ОПЕРАЦІЙ НА РЕЗУЛЬТАТИ ЕКСТРАКОРПОРАЛЬНОГО ЗАПЛІДНЕННЯ У ЖІНОК ІЗ ЕНДОМЕТРІОЗОМ ЯЄЧНИКІВ
Authors: ХМІЛЬ С. В. , ВІЗНЯК Т. Б.
Published: September 2024

Мета роботи: оцінити вплив проведених ендометріозасоційованих оперативних втручань на результати екстракорпорального запліднення у жінок із ендометріозом яєчників.
Матеріали і методи. Проведено ретроспективний аналіз 112 амбулаторних медичних карток жінок із безпліддям. Було сформовано 3 групи дослідження: І група – 42 жінки з ендометріозасоційованим безпліддям, які в анамнезі мають хірургічне лікування ендометріом яєчника та не мають активної ендометріоми станом на початок циклу стимуляції; ІІ група – 40 пацієнток із одно- або двобічними активними ендометріомами, які не проходили оперативне лікування; ІІІ (контрольна) група – 30 жінок із безпліддям, пов’язаним із виключно трубним фактором.
Результати. За даними анамнезу щодо перенесених оперативних втручань та хірургічних маніпуляцій було встановлено значущі відмінності між групами. Лапаротомія та лапароскопія були частими оперативними втручаннями у жінок першої групи та в групі контролю. Частина жінок вказували на проведення у них лапароскопії із діагностичною метою, для встановлення ймовірної причини безпліддя або верифікації діагнозу зовнішнього ендометріозу. За даними ембріологічних протоколів установлена менша кількість зрілих фолікулів >18 мм у діаметрі в першій групі, що пов’язано із термічним впливом лапароскопічних втручань на тканину яєчника, та в другій групі жінок, які мають активні ендометріоми на момент стимуляції, що пояснюється гіршим доступом до деяких фолікулів унаслідок наявності кісти. Найменша кількість отриманих ооцитів (5,86±0,35) та найбільша частка серед них незрілих була зафіксована в першій групі, що не корелювало із величиною стимуляції та може бути пояснено відсутністю необхідної чутливості рецепторів фолікулів до гонадотропінів унаслідок попередніх лапароскопічних втручань. Найменша кількість бластоцист була отримана в першій групі (1,09±0,16), що є очікуваним результатом, зважаючи на найменшу кількість отриманих ооцитів (5,86±0,35), з яких зрілих та правильно запліднених ооцитів ((3,02±0,32) та (1,68±0,17) відповідно) також було найменше, порівняно із жінками другої досліджуваної та контрольної груп.
Висновки. Проведені ендометріозасоційовані оперативні втручання в анамнезі є потенційним фактором безуспішного циклу ЕКЗ за рахунок негативного впливу на вихід ооцитів, їх морфологічну якість та показники запліднення і бластуляції.
ВПЛИВ ПОШКОДЖЕННЯ ШКІРИ НА ДІУРЕЗ ТА ФІЛЬТРАЦІЙНУ ФУНКЦІЮ НИРОК ЗА УМОВ ПОЄДНАНОЇ ТРАВМИ ТА ЕФЕКТИВНІСТЬ PRP-ТЕРАПІЇ
Authors: ПРИМАЧЕНКО Т. В. , ГУДИМА А. А.
Published: September 2024

Мета роботи: зʼясувати вплив пошкодження шкіри на діурез та фільтраційну функцію нирок за умов поєднаної травми та оцінити ефективність PRP-терапії в умовах досліджуваної патології.
Матеріали і методи. В експериментах на 96 статевозрілих білих щурах-самцях лінії Вістар масою 200–220 г під тіопентало-натрієвим наркозом моделювали скелетну травму (дослідна група 1), поєднану травму, яка включала скелетну травму, ускладнену механічним пошкодженням шкіри (дослідна група 2). У дослідній групі 3 щурам з поєднаною травмою проводили PRP-терапію: алогенну плазму, збагачену тромбоцитами, вводили внутрішньодермально по 0,1 мл в ділянку рани шкіри. Через 3, 7, 14, 21 та 28 діб після моделювання травм у щурів визначали функціональний стан нирок методом водного навантаження: встановлювали діурез та швидкість клубочкової фільтрації.
Результати. Модельована скелетна травма, яка включає перелом стегнової кістки та гостру крововтрату, викликає сповільнення діурезу та швидкості клубочкової фільтрації. Додаткове пошкодження шкіри сприяє поглибленню порушень. Показники стають статистично вірогідно меншими, порівняно зі щурами з самою скелетною травмою. За умов поєднаної травми використання PRP-терапії у групі щурів викликає поступове зростання діурезу та швидкості клубочкової фільтрації з 7 до 28 діб експерименту. Порівняно з травмованими щурами без корекції показники стають статистично вірогідно більшими за величиною діурезу починаючи з 21 доби експерименту, за величиною швидкості клубочкової фільтрації – через 28 діб. Отже, на тлі PRP-терапії в період пізніх проявів травматичної хвороби настає покращення фільтраційної функції нирок, що вказує на перспективність методу для зменшення системного патогенного впливу на організм і вимагає подальшого поглибленого вивчення.
ПОВТОРНІ ОПЕРАЦІЇ В АБДОМІНАЛЬНІЙ ХІРУРГІЇ
Authors: КОРОЛЬ Я. А. , ШЕРЕМЕТА С. О. , КРУК О. С. , КОРОЛЬ Р. Я.
Published: September 2024

Мета: вивчення причин, показань та результатів виконання релапаротомій після хірургічних операцій на органах черевної порожнини залежно від нозології і характеру першого операційного втручання.
Матеріал і методи. В ході дослідження проаналізовано 38 карт стаціонарних хворих, яких проліковано в клініці хірургії, пластичної хірургії та ендоскопії ФПДО ЛНМУ імені Данила Галицького (база – відділення № 2 центру хірургії та онкології КНП 1 ТМО м. Львова) за період з січня 2021 до грудня 2023 рр. Переважали жінки (21 хвора – 55,3 %) віком від 24 до 85 років (середній вік – (61,8±16,32) років). Основною патологією, яка у післяопераційному періоді потребувала виконання релапаротомій, був колоректальний рак (8 пацієнтів – 21,1 %). Тяжкість передопераційного стану хворого за ASA становила I і II ступенів (по 12 пацієнтів – 31,6 %), III ступеня – 10 (26,3 %) та IV – 4 (10,5 %). Ступені тяжкості ускладнень за класифікацією Clavien–Dindo були здебільшого IIIb – 17 пацієнтів (44,7 %) та IVb – 18 (47,4 %).
Результати. Усі релапаротомії здійснено під ендотрахеальним наркозом. Переважній більшості пацієнтів (36 – 94,7 %) проведено вимушені повторні втручання, причому термін їх виконання здебільшого становив понад 10 діб після первинного операційного втручання. Повторні абдомінальні втручання були від найпростіших (дренування черевної порожнини), до таких, які складають певну технічну складність (правобічна геміколектомія). Ускладнення у ранньому післяопераційному періоді після релапаротомій виникло в 16 (42,1 %) пацієнтів, причому в 11 (28,9 %) для їх ліквідації довелось здійснювати повторні втручання, зокрема, в 7 (18,4 %) – один раз та багаторазово – у решти. Серед ускладнень здебільшого було прогресування сепсису. Помер 21 пацієнт; післяопераційна летальність становила 55,3 %. Основною причиною летального наслідку була поліорганна недостатність (18 хворих).
Judicialización de la política y guerras jurídicas en el siglo XXI: un análisis sobre los casos de Argentina, Brasil y Ecuador
Authors: Prego Florencia
Published: September 2024

La judicialización de la política y las guerras jurídicas constituyen un tema central en la agenda política y en la opinión pública, y abre discusiones y debates en el seno del campo académico. En el presente trabajo buscamos problematizar los procesos de judicialización impulsados contra dirigentes políticos y elencos gubernamentales que protagonizaron los procesos de cambio social que se libraron en América Latina en el siglo XXI. Más precisamente abordaremos, en clave comparada, los casos de Cristina Fernández de Kirchner en Argentina, Lula Da Silva en Brasil y Rafael Correa en Ecuador. Desde nuestra perspectiva, las guerras jurídicas constituyen un fenómeno propio del siglo XXI y abren una nueva crisis en el seno de las democracias. Se trata de una estrategia sostenida en la lógica de la guerra para desacreditar al adversario político a través de mecanismos institucionales y mediáticos apelando tanto a formatos legales (sostenidos en el derecho penal y en las reglas de la democracia formal) e ilegales (a partir de la creación de normas de excepción) con el objetivo no solo de inhibir o proscribir a determinadas fuerzas y/o dirigentes sino de condicionar los escenarios electorales y generar un efecto disciplinador sobre el sistema político. Desde nuestra perspectiva, las guerras jurídicas constituyen un fenómeno propio del siglo XXI que abren una nueva crisis en el seno de las democracias. Se trata de una estrategia sostenida en la lógica de la guerra para destruir al adversario político a través de mecanismos institucionales y mediáticos apelando tanto a formatos legales (sostenidos en el derecho penal y en las reglas de la democracia formal) e ilegales (a partir de la creación de normas de excepción) con el objetivo no solo de inhibir o proscribir a determinadas fuerzas y/o dirigentes sino de condicionar los escenarios electorales y generar un efecto disciplinador sobre el sistema político y las dinámicas estatales.
A nova direita e os livros: autores, editoras e best sellers de direita no Brasil e na Argentina
Authors: Pereira Thiago Augusto C. , Saferstein Ezequiel
Published: September 2024

En los últimos años, las derechas han vuelto a adquirido relevancia en el campo político en América Latina. El involucramiento de los jóvenes y el fenómeno de las redes sociales para la articulación de agentes, subjetividades y prácticas derechistas han sido algunos de los temas más abordados en los estuidos recientes. En este trabajo nos enfocaremos en la producción editorial de libros de las autodenominadas nuevas derechas en Brasil y en Argentina, que generaron un segmento prolífico y redituable en términos editoriales así como resonante en términos culturales y políticos. Entendidos como productos culturales, comerciales e ideológicos, los libros juegan un papel importante en la consolidación de un marco discursivo asociado a la "nueva derecha" en Argentina y Brasil. Además, ilustran cómo los mercados editoriales dan cuenta de una renovación de los referentes ideológicos que encarnan estos autores. A partir del análisis del derrotero editorial y discursivo de tres autores brasileros y tres argentinos enmarcados en las nuevas derechas, en este trabajo exploraremos la relevancia política, comercial y cultural de un tipo de producción históricamente consagrada en un escenario de transformaciones culturales y políticas.
Diversidade de espécies vegetais em parques urbanos: um estudo em áreas verdes da cidade do Cabo de Santo Agostinho, Pernambuco
Authors: Aniceto Fabricio David Simplicio , Silva Lenival Santana da , Gadelha Fernando Henrique de Lima
Published: September 2024

Os ambientes urbanos têm áreas verdes que são essenciais à sustentabilidade dos ecossistemas. No entanto, a concepção dessas infraestruturas verdes pode resultar em efeitos negativos, principalmente devido à falta de planejamento para implantação da flora urbana. Assim, esta pesquisa busca, por meio de um inventário, analisar a composição, origem (nativa ou exótica ao Brasil, e nativa ou exótica à Mata Atlântica, típica do local em estudo), diversidade e similaridade de espécies arbóreas presentes em quatro parques urbanos da cidade do Cabo de Santo Agostinho, Pernambuco. Um total de 71 espécies e 26 famílias foram registradas, com maior frequência de Cocos nucifera (18,3%) e Fabaceae (12 spp.). Em geral, 40,8% das espécies são nativas do Brasil e 59,2% são exóticas, enquanto 25,4% são naturais da Mata Atlântica de Pernambuco. Os parques apresentam média diversidade de flora, mas exibem baixa similaridade entre si. Conclui-se que a vegetação dos espaços é marcada pelo uso de espécies exóticas, que podem comprometer a integridade dos ecossistemas locais, e demonstra a necessidade de uma melhor gestão das áreas verdes urbanas.
Mori Arinori: Japan’s Diplomat in Washington, D.C.
Authors: Van Sant John E.
Published: September 2024

This article briefly examines the life of Mori Arinori, who in 1871 became Japan’s first resident diplomat in Washington, D.C., with the primary assignment of making preparations for the upcoming Iwakura Mission. Mori’s pedigree of being from a samurai family from Satsuma domain and his unusual background of having already lived in Britain and the United States led senior officials of the new Meiji Imperial government to name Mori to the all-important position of being Japan’s top representative to the United States despite his youth – he was only 23 years old at the time of his appointment. Notwithstanding his occasional impatience with Japanese traditions and the more reserved senior officials of the Iwakura Embassy, Mori’s connections in Washington D.C., his understanding of American society, and his skill at the English language significantly contributed to the institutional, cultural, and economic information that members of the Japanese delegation gathered. Mori’s post-Washington career as an intellectual, diplomat, and top education official in Japan in the late 1870s and 1880s also contributed to his country’s progression from the collapse of the Tokugawa Shogunate to the cusp of Japan’s international recognition as a major power in a world being transformed by industrialization and imperialism.
Contribution to the genus Clypeocaenis Soldán, 1978 (Ephemeroptera: Caenidae) from Lao People’s Democratic Republic with a key to Oriental species
Authors: VANNACHAK VIENGKHONE , MALZACHER PETER , SANGPRADUB NARUMON
Published: September 2024

Larvae of Clypeocaenis laosensis sp. nov. were collected from the Xe Nou River, Xe Bang Hieng River, and Tha Hao Stream in central and southern Lao PDR. This investigation also encompassed the examination of eggs extracted from female larvae, and we give here the first egg description of Cl. multisetosa Soldán, 1978 and Cl. oligosetosa Soldán, 1983. Clypeocaenis laosensis sp. nov. is closely related with Cl. gayathri Balasubramanian & Muthukatturaja, 2020 and Cl. kaveri Balasubramanian & Muthukatturaja, 2021. The new species is distinguishable from other Clypeocaenis species by specific morphological traits. These include the number of setae on the clypeus, the morphology of the labial palpus, the length of marginal setae on the middle and hind femora, setae of the transverse row on the forefemur, and body surface microtrichia. A detailed comparison of the morphological features between this new species and its closely related species is provided. Furthermore, the first-time reporting of Cl. multisetosa and Cl. oligosetosa in Lao PDR expands the known Caenidae diversity in the country to five species. A key to the nymphs of the Oriental species of Clypeocaenis is provided.
Effect of Y on Oxidation Behavior of Directionally Solidified Ni-Based Single-Crystal Superalloy
Authors: Zhao Zihan , Guan Kai , Cui Renjie , Qin Jianchao , Huang Zhaohui
Published: September 2024

The effect of yttrium (Y) addition on the oxidation behavior of a Ni-based directionally solidified single-crystal superalloy is investigated in this study. Isothermal oxidation tests for samples with different levels of Y addition are conducted at 1100 °C in air. The Y content of the samples is determined by the actual pickup amount obtained from an Inductively Coupled Plasma-Atomic Emission Spectrometry test. It is discovered that the addition of Y increases the oxide resistance by the scale of an adhesive double-layer oxide, which is composed of Al2O3 and spinel Ni(Cr,Al)2O4. With 70 ppm of Y addition, the oxidation mass gain decreases from 12.6 g/m2 for the alloy without Y addition to 5.3 g/m2, and the oxidation rate decreases significantly. In addition, the internal nitride disappears after Y doping because of an increase in oxidation scale adherence and a decrease in oxidation products. In this study, the alloy with 660 ppm Y addition demonstrates the best oxidation resistance.
The use of nanomaterials as drug delivery systems and anticancer agents in the treatment of triple-negative breast cancer: an updated review (year 2005 to date)
Authors: Ndongwe Tanaka , Zhou Angel-Alberta , Ganga Nelisa Paidamwoyo , Matawo Nyaradzo , Sibanda Unami , Chidziwa Tinotenda Vanessa , Witika Bwalya A. , Krause Rui W. M. , Matlou Gauta Gold , Siwe-Noundou Xavier
Published: September 2024

Triple-negative breast cancer (TNBC) is characterised by the lack or low expression of estrogen, progesterone, and human epidermal growth factor receptor 2 receptors. TNBC has a high recurrence rate, swiftly metastasizes, and has a high mortality rate. Subsequently, the increase in cases of TNBC has signaled the need for treatment strategies with improved drug delivery systems. New diagnostic approaches, chemical entities, formulations particular those in the nanometric range have emerged after extensive scientific research as alternative strategies for TNBC treatment. As compared to contemporary cancer therapy, nanoparticles offer peculiar tunable features namely small size, shape, electrical charge, magnetic and fluorescent properties. Specifically in targeted drug delivery, nanoparticles have been demonstrated to be highly efficient in encapsulating, functionalization, and conjugation. Presently, nanoparticles have ignited and transformed the approach in photodynamic therapy, bioimaging, use of theranostics and precision medicine delivery in breast cancer. Correspondingly, recent years have witnessed a drastic rise in literature pertaining to treatment of TNBC using nanomaterials. Subsequently, this manuscript aims to present a state-of-the-art of nanomaterials advance on TNBC treatment; the ubiquitous utility use of nanomaterials such as liposomes, dendrimers, solid lipid nanomaterials, gold nanomaterials and quantum dots as anticancer agents and drug delivery systems in TNBC.
The prognostic role of palliative gastrectomy in advanced gastric cancer: a systematic review and meta-analysis
Authors: Luo Desheng , Xu Hongtao , Jiang Chuan , Zheng Jingjing , Wu Dan , Tou Laizhen , Que Haifeng , Sun Zheng
Published: September 2024

Background

The effectiveness of palliative gastrectomy for advanced GC remains a topic of debate. This study sought to establish whether palliative gastrectomy has an impact on prolonging survival.

Methods

We carried out systematic searches in PubMed, Cochrane Library, Web of Science, and the EMBASE databases from database inception to July 2023 to gather studies that examined the connection between palliative gastrectomy and the prognosis of advanced GC. The study employed overall survival as the primary outcome, with the hazard ratio serving as the selected parameter to gauge the association. Subgroup analyses were performed to delve into potential differences within the included studies, categorizing them by study region and sample size in order to examine possible sources of heterogeneity. The stability of individual studies was assessed through sensitivity analysis. The analysis included 20 articles, encompassing a total of 23,061 patients.

Results

According to the meta-analysis results, patients who underwent palliative gastrectomy exhibited a noteworthy enhancement in overall survival (HR: 1.49; 95% CI: 1.12–1.99; P = 0.006) in comparison to those who did not receive this procedure. There was no association between the type of surgery and the length of hospital stay, as revealed by the analysis (HR = -0.02; 95% CI: -0.84–0.81; P = 0.970).

Conclusions

Based on this meta-analysis, patients with advanced gastric cancer who underwent palliative gastrectomy may experience an extended survival duration without a significant prolongation of their hospitalization.
ETDRS grading with CLARUS ultra-widefield images shows agreement with 7-fields colour fundus photography
Authors: Santos Ana Rita , Ghate Sejal , Lopes Marta , Rocha Ana Cláudia , Santos Torcato , Reste-Ferreira Débora , Manivannan Niranchana , Foote Katharina , Cunha-Vaz José
Published: September 2024

Background

To analyse and compare the grading of diabetic retinopathy (DR) severity level using standard 35° ETDRS 7-fields photography and CLARUS™ 500 ultra-widefield imaging system.

Methods

A cross-sectional analysis of retinal images of patients with type 2 diabetes (n = 160 eyes) was performed for this study. All patients underwent 7-fields colour fundus photography (CFP) at 35° on a standard Topcon TRC-50DX® camera, and ultra-widefield (UWF) imaging at 200° on a CLARUS™ 500 (ZEISS, Dublin, CA, USA) by an automatic montage of two 133° images (nasal and temporal). 35° 7-fields photographs were graded by two graders, according to the Early Treatment Diabetic Retinopathy Study (ETDRS). For CLARUS UWF images, a prototype 7-fields grid was applied using the CLARUS review software, and the same ETDRS grading procedures were performed inside that area only. Grading of DR severity level was compared between these two methods to evaluate the agreement between both imaging techniques.

Results

Images of 160 eyes from 83 diabetic patients were considered for analysis. According to the 35° ETDRS 7-fields images, 22 eyes were evaluated as DR severity level 10–20, 64 eyes were evaluated as DR level 35, 41 eyes level 43, 21 eyes level 47, 7 eyes level 53, and 5 eyes level 61. The same DR severity level was achieved with CLARUS 500 UWF images in 92 eyes (57%), showing a perfect agreement (k > 0.80) with the 7-fields 35° technique. Fifty-seven eyes (36%) showed a higher DR level with CLARUS UWF images, mostly due to a better visualization of haemorrhages and a higher detection rate of intraretinal microvascular abnormalities (IRMA). Only 11 eyes (7%) showed a lower severity level with the CLARUS UWF system, due to the presence of artifacts or media opacities that precluded the correct evaluation of DR lesions.

Conclusions

UWF CLARUS 500 device showed nearly perfect agreement with standard 35° 7-fields images in all ETDRS severity levels. Moreover, CLARUS images showed an increased ability to detect haemorrhages and IRMA helping with finer evaluation of lesions, thus demonstrating that a UWF photograph can be used to grade ETDRS severity level with a better visualization than the standard 7-fields images.

Trial registration

Approved by the AIBILI - Association for Innovation and Biomedical Research on Light and Image Ethics Committee for Health with number CEC/009/17- EYEMARKER.
Innovate! Accelerate! Evaluate! Harnessing the RE-AIM framework to examine the global dissemination of parenting resources during COVID-19 to more than 210 million people
Authors: Lachman Jamie M. , Nurova Nisso , Chetty Angelique Nicole , Fang Zuyi , Swartz Alison , Sherr Lorraine , Mebrahtu Helen , Mwaba Kasonde , Green Ohad , Awah Isang , Chen Yuanling , Vallance Inge , Cluver Lucie
Published: September 2024

Background

Parents were at the forefront of responding to the needs of children during the COVID-19 pandemic. This study used the RE-AIM framework to examine the Reach, Effectiveness, Adoption, Implementation, and Maintenance of a global inter-agency initiative that adapted evidence-based parenting programs to provide immediate support to parents.

Methods

Data were collected via short surveys sent via email, online surveys, and analysis of social media metrics and Google Analytics. Retrospective surveys with 1,303 parents and caregivers in 11 countries examined impacts of the resources on child maltreatment, positive relationship building, parenting efficacy, and parenting stress.

Results

The parenting resources were translated into over 135 languages and dialects; reached an estimated minimum 212.4 million people by June 2022; were adopted by 697 agencies, organizations, and individuals; and were included in 43 national government COVID-19 responses. Dissemination via social media had the highest reach (n = 144,202,170, 67.9%), followed by radio broadcasts (n = 32,298,525, 15.2%), text messages (n = 13,565,780, 6.4%), and caseworker phone calls or visits (n = 8,074,787, 3.8%). Retrospective surveys showed increased parental engagement and play, parenting self-efficacy, confidence in protecting children from sexual abuse, and capacity to cope with stress, as well as decreased physical and emotional abuse. Forty-four organizations who responded to follow-up surveys in April 2021 reported sustained use of the resources as part of existing services and other crisis responses.

Conclusion

This study highlights the importance of a) establishing an international collaboration to rapidly adapt and disseminate evidence-based content into easily accessible resources that are relevant to the needs of parents; b) creating open-source and agile delivery models that are responsive to local contexts and receptive to further adaptation; and c) using the best methods available to evaluate a rapidly deployed global emergency response in real-time. Further research is recommended to empirically establish the evidence of effectiveness and maintenance of these parenting innovations.
Adrenal tumours in patients with pathogenic APC mutations: a retrospective study
Authors: Lin Lyman , Beshay Victoria , Macrae Finlay
Published: September 2024

Background

Adrenal tumours are associated with familial adenomatous polyposis (FAP). In the literature, most studies use the clinical definition of FAP (more than 100 adenomatous polyps found in endoscopic studies). However, not all patients that meet clinical criteria for FAP carry pathogenic mutations in the adenomatous polyposis coli (APC) gene, as there is genetic heterogeneity responsible for FAP with the polyposis sometimes explained by genetic and environmental factors other than pathogenic APC mutations. Reciprocally, not all the patients with pathogenic APC variants will fulfil the classic criteria of FAP.

Objective

This study aims to investigate the characteristics of adrenal tumours in patients with pathogenic or likely pathogenic APC variants and explore the hormonal function of these patients.

Method

This is a retrospective cohort study. Patients with pathogenic or likely pathogenic APC variants were recruited and their radiological assessments were reviewed. Patient demographic data, APC variants, adrenal mass characteristics and hormonal testing results were collected.

Result

The prevalence of adrenal mass was 26.7% (24/90) among patients with pathogenic or likely pathogenic APC variants. Using the classic definition, the prevalence was 32.4% (22/68). Four patients had adrenal hormone testing, two of which had Conn’s syndrome and two had nonspecific subclinical results.

Conclusion

In our cohort, the prevalence of adrenal tumours among patients with pathogenic and likely pathogenic APC mutations is at least twice to three times higher than the general population prevalence reported from international population-based studies. The hormonal functions of patients with pathogenic APC variants and adrenal tumours can be investigated with routine testing in further research.
Add-on hemoperfusion in SARS-CoV-2-infected pregnant patients: a case series
Authors: Chiewroongroj Supattra , Naorungroj Thummaporn , Ratanarat Ranistha
Published: September 2024

Background

Pregnant women are more likely to have a higher severity of illness after being infected with coronavirus disease 2019 compared with the general population, particularly in the hyperinflammatory phase. However, immunomodulatory drugs are contraindicated and have been associated with an increased risk of fetal abnormalities. Therefore, we are reporting our experience with the use of HA330 hemoperfusion in combination with standard therapy in severe to critical coronavirus disease 2019 cases among pregnant patients.

Case presentation

From January 2020 to December 2021, four pregnant Thai women were treated with hemoperfusion using a cytokine adsorptive technique. The patients’ ages ranged from 21 to 36 years old, and their gestational ages at the time of admission ranged from 18 to 38 weeks. Two patients required intubation. Extracorporeal blood purification with an adsorptive cartridge (HA330®, Jafron, China) was applied as an adjunctive strategy to standard therapy approximately one week after the onset of symptoms, and most patients received three sessions of hemoperfusion. The baseline C-reactive protein level was greater than 80 mg/dL. The results showed that hemoperfusion could decrease the C-reactive protein level by approximately 80% and improve oxygenation. The newborns were delivered by Cesarean section without complications. Neither mortality nor serious adverse events related to hemoperfusion occurred.

Conclusion

This report may help ensure the use of the hemoperfusion strategy in pregnant patients during a cytokine storm. However, a larger cohort is needed to confirm its safety and efficacy.
Impact of an Etoposide Chemotherapy Shortage on Patients With Extensive-Stage Small-Cell Lung Cancer: Results of a Natural Experiment
Authors: Browne Claire , Ayoub Toufic , Samarasinghe Nadeesha , Hussaini Syed , Warner Andrew , Black Morgan , Palma David A. , Raphael Jacques , Kuruvilla Sara , Blanchette Phillip S.
Published: September 2024

PURPOSE

A shortage of essential intravenous (IV) etoposide lasted from 2018 until 2020 in Ontario, Canada, allowing for a natural experiment in which external factors (IV etoposide availability) dictated patients' treatment assignment. The purpose of this study was to evaluate the impact of this IV etoposide shortage (IVES) on patient care outcomes.

METHODS

Individuals with extensive-stage small-cell lung cancer (ES-SCLC) treated during a pre-IVES (November 2017-October 2018) and IVES (November 2018-October 2019) time intervals were retrospectively reviewed at the Verspeeten Family Cancer Centre. We investigated the association of the shortage on health care utilization and survival using a time-to-event analysis, Cox proportional hazards and logistic regression modeling.

RESULTS

A total of 119 patients with ES-SCLC were assessed, 49 in the pre-IVES interval and 70 in the IVES interval. The median age was 68 (IQR, 62-74) years, 48% (n = 57) were male, 33% (n = 39) had CNS metastases, and 69% (n = 82) received first-line systemic therapy. Alternate regimens used for IVES cohort included IV platinum-oral (PO) etoposide, IV platinum-IV irinotecan, and PO etoposide monotherapy. An adjusted multivariable model demonstrated a significant increase in hospitalization (odds ratio, 2.30 [95% CI, 1.01 to 5.24]; P = .047) and shorter progression-free survival (PFS; hazard ratio, 1.79 [95% CI, 1.19 to 2.68]; P = .005) during the IVES.

CONCLUSION

This study demonstrated increased hospitalization, and decreased PFS, among patients with ES-SCLC treated with alternate chemotherapy regimens during an IVES. The impact of cancer drug shortages can be harmful, and optimizing a more secure drug supply with mitigation strategies is warranted.
Suicídio no Mato Grosso, 2015-2021
Authors: Luna Nascimento Sheila Maria de , Braga de Almeida Fernanda , Pereira Sebba Filho Rogério , Ribeiro Livia Maria , Gomes Timóteo Vykthor Maryanno , Nascimento Iracema , Mendes Oliveira Luciana
Published: September 2024

Objetivo: analisar o perfil epidemiológico das vítimas fatais de lesões autoprovocadas em Mato Grosso entre 2015 e 2021 e a influência da COVID-19 nesse cenário. Métodos: estudo epidemiológico descritivo sobre suicídios em Mato Grosso de 2015 a 2021, utilizando dados do DATASUS. Resultados: registraram-se 1.512 mortes por suicídio. Nos sete anos avaliados, Mato Grosso superou os números nacionais em quatro anos. Em 2020, foram 7,4 óbitos por 100 mil habitantes, um aumento de 6,9% em relação a 2019, enquanto no Brasil o aumento foi de apenas 1,5%. Até 2020, a maioria das vítimas tinham entre 20 e 29 anos, mudando para 30 a 39 anos em 2021. A prevalência foi maior entre os homens e predominaram os solteiros, e os métodos mais usados foram enforcamento, estrangulamento e sufocação. Autointoxicação teve maior crescimento com 58,3% de 2015 a 2020 e 133% de 2015 a 2021. Entre 2020 e 2021, houve um aumento adicional de 47,4%. O uso de objetos cortantes e contundentes também aumentou, foram 833,3% de 2015 a 2020 e 1100% de 2015 a 2021. Entre 2020 e 2021, a taxa desse método de suicídio aumentou em 28,6%. Conclusão: o crescimento no período pandêmico foi semelhante aos outros anos, exceto para os métodos utilizados. É necessário implementar ações mais eficazes para mitigar os suicídios entre jovens adultos em Mato Grosso, especialmente focando nas características apresentadas.
RESEARCH OF THE CAREER COUNSELING MARKET IN RUSSIA
Authors: Kazaeva E. , Chelnokova O.
Published: September 2024

Modern socio-economic processes and changes in social structure are intensifying the need for career counseling. Increased competition in the labor market requires job seekers to have skills for effective job searching, resume writing, and successful performance in interviews, consequently increasing the demand for career counselors. The research aims to analyze current trends in the field of career counselor vacancies after the pandemic in Russia, including an analysis of changes in demand for career counseling and understanding of company preferences when posting such vacancies. The study offers a comprehensive analysis of the demand for career counseling after the pandemic, using statistical data and information on vacancies from various platforms. The practical significance of the research lies in the development of strategies for career program advancement, understanding the needs of employees and job seekers, as well as identifying specific features of posting vacancies for career counselors on different platforms. The theoretical and methodological aspects of researching the issues of career counseling in Russia assess the transformation of socio-economic processes and the modern social structure, analyze the global market for career counseling, and investigate government support programs. The research confirmed the relevance, significance, and potential for further development of career counseling in Russia in the context of contemporary challenges in the labor market.
SUBJECTIVE WELL-BEING AT WORK: APPROACHES TO MONITORING STAFF SELF-FEELING
Authors: Fedorova A. , Morohov N.
Published: September 2024

A direct correlation between the level of staff well-being and the company’s profitability has been proven by both foreign and Russian studies. However, one of the unresolved problems today remains the fact that well-being at work is still not considered as a factor and resource for the productivity and efficiency of employees. The reality of modern life highlights the need for a rapid rethinking of the nature and patterns of connections between well-being at work and the state of labour productivity, socio-economic assessments of this relationship, and the development of management and digital solutions for monitoring and maintaining an adequate level of staff well-being. The article presents the results of a survey of representatives of the expert community conducted by the authors to identify the current aspects of well-being at work, as well as a brief description of the concept of a digital service developed by the authors for monitoring the well-being of employees through self-assessment.
How to Make My Bug Bounty Cost-Effective? A Game-Theoretical Model
Authors: Zhang Leting , Demirezen Emre M. , Kumar Subodha
Published: September 2024

A bug bounty program (BBP) is an innovative crowdsourcing security solution increasingly adopted by organizations. We use a game-theoretical model to analyze how key characteristics impact BBPs and offer practical insights into managing a BBP as part of an organization’s vulnerability management for better cost-effectiveness. Our findings indicate that organizations with high patching complexity should announce lower bounties, especially if they face limited security resources. BBPs should complement, not substitute, an organization’s security characteristics. Evaluating patching complexity and security posture is crucial when designing a BBP. Furthermore, security researchers drive BBP performance. Higher productivity in researchers doesn’t always require higher bounties even with high postdiscovery costs. Novice productivity can increase total costs if unit postdiscovery costs are high, whereas expert productivity consistently reduces costs. Organizations should disclose high-level product and information technology (IT) features to increase expert productivity. The number of security researchers in a BBP is important, but increasing their numbers doesn’t always necessitate higher bounties. A larger crowd may not always be cost-effective. Lastly, enhanced legal protection for security researchers might not increase organizational risks, especially in organizations with robust security or less sophisticated IT infrastructure. Industrial associations and policymakers should consider these factors in standards and legal frameworks.
Comparison of Dietary Behaviors and Health-Related Quality of Life of the Elderly Based on Their Household Type in Korea
Authors: Lee Joo-Eun
Published: September 2024

This study analyzed the raw data from the 2021 National Health and Nutrition Survey conducted annually in Korea to investigate the dietary behavior, nutrient intake, and health-related quality of life of the elderly in the community based on their household type: single-person, couple, or non-couple family household. As a result of the study, based on the household type, significant differences were found in the frequency of breakfast, lunch, and dinner, as well as in the frequency of consuming vegetables and fruits (P<0.05, P<0.01, P<0.001). After analyzing the impact of household type on the depression and happiness levels of the surveyed elderly, it was found that the depression levels of elderly individuals in single-person households were significantly 1.279 times higher, while their feelings of happiness were 0.561 times lower compared to elderly individuals living with their family, including a spouse (P<0.05, P<0.001). In order to enhance the health-related quality of life for elderly individuals living alone with low income and education levels, it is essential to provide systematic management and support activities.
Dietary Macronutrient and Micronutrient Intake Among Corporate Employees Aged 30 to 40 Years Residing in Mumbai, India
Authors: Motwani Meghna S. , Deorukhkar Kasturi V. , Sanwalka Neha , Kochrekar Nikita S. , Pai Akshay , Mitra Anuradha , Mandalika Subhadra
Published: September 2024

The rising burden of non-communicable diseases (NCDs) in India necessitates more studies on nutritional intake and dietary behaviour. While data exists on low-income groups, rural populations and the population at large, limited information exists on that of urban, working professionals – a demographic that has the means and access to make informed choices, and yet, have a disproportionately high risk of NCDs. The aim of this study was to investigate nutrient intake in Indian professionals. A cross-sectional study was conducted on 214 working professionals (aged 30-40 years; 69 females and 145 males) in Mumbai. Habitual food intake was investigated by two 24-hour recalls and a semi-quantitative food frequency questionnaire. Nutrient adequacy ratios were calculated in comparison to Indian estimated average requirements. Compared to recommendations, a lower total energy and carbohydrate intake, while a higher protein and fat intake was observed among the participants. However, the intake of omega-3 fats, and overall fruit and vegetable intake was poor. A significantly higher energy from proteins and fats was observed among non-vegetarians, while vegetarians consumed more energy from carbohydrates. Insufficient intake of vitamins and minerals was prevalent with over 50% of study participants consuming <50% of their required intake of Vitamin A, B12, folate, riboflavin, zinc and potassium. Intake of copper, pyridoxine and iron were also suboptimal. To conclude, the insufficient intake of micronutrient and macronutrient imbalances in the studied population, highlights the urgency of targeted nutritional interventions and education in urban, corporate populations in India, to mitigate the risk of NCDs.
Natural Radioactivity in some Local Food Samples Consumed by Children in Iraq
Authors: Mohammed Zahrah Baqer , Obai Iman Sabah , Jaafar Noor Ali , Abojassim Ali Abid , Al-Khayfawee Ahmed Ali Ghali
Published: September 2024

This work was directed towards studying the specific activity of natural radioactivity (40k, 238U, and 232Th) in 13 samples of foodstuff that are consumed by children in Iraq. The foodstuffs such as biscuit, cocoa powder, milk powder, indomie, and soup were collected from markets in the Al-Najaf governorate. This food was analyzed in the laboratory, which belongs to the University of Kufa, using a scintillation detector (NaI(Tl)) detector (gamma spectrometer systems) and provided with software MESTRO-32. The results found that, the specific activity for potassium-40 were ranged from 52.11 Bq/kg to 619.61 Bq/kg, while the specific activity for uranium-238 ranged between 4.11 Bq/kg to 18.9 Bq/kg, but for thorium-232 were ranged from 0.39 Bq/kg to 12.06 Bq/kg. The specific activity for 40K, 238U, and 232Th for all samples was found to be within the worldwide range for radioactivity in food 420, 30, and 45 Bq/kg, respectively, except for cocoa powder samples have specific activity for 40K higher than worldwide. This study has shown that the levels of radioactivity in most samples of children food were within the limit value of organization UNSCEAR. Finally, the present study will provide data about natural radioactivity in food used by children in all governorates of the country to protect all children.
Narrative Review on the Factors Affecting Fast Food Consumption among Adults
Authors: Bhatoolaul Yogeshwaree , Alrefaei Abdulwahed Fahad , Jeewon Rajesh
Published: September 2024

As a result of increasing industrialisation in various countries and the change in their populations' eating patterns, residents may be shifting from a low-calorie diet to one with a high energy density. People tend to consume fewer fruits and vegetables and instead, they opt for more refined carbs, animal protein, processed meat, and fast food. This highlights how, as globalisation progresses, people are rapidly losing their cultural identities concerning traditional healthy foods and local produce. Fast food intake and lifestyle changes have contributed significantly to the increase in the prevalence of food-related chronic diseases. Adults suffering from diet-related difficulties, particularly chronic illness, have become the primary cause of morbidity and mortality in many countries. Adults' fast food consumption is influenced by factors such as chronological age, gender, socioeconomic level, food availability and accessibility, BMI, physical activity, and nutrition knowledge. This review focuses on aspects that influence people's fast food eating habits, providing insights into how health-related problems associated with fast food consumption can be curbed.
breaking boundaries: children activist as epistemic agents within contours of epistemic marginalisation
Authors: Maldonado castañeda Pedro hernando
Published: September 2024

The article delves into the realm of child environmental activism, portraying it as a concerted response aimed at challenging the prevailing social and political status quo, which systematically underestimates the role of children in decision-making within political and social spheres. It highlights the paramount importance of the epistemological framework that encompasses children's experiences, emphasising how their exclusion from political and social discourse leads to epistemic marginalisation. This exclusion not only prevents children from assuming the role of epistemic agents but also deprives them of agency and perpetuates existing inequalities. From a philosophical perspective, the article proposes a thorough analysis of children's epistemic agency, introducing the concept of 'epistemic capability'. It argues that, despite their social marginalisation, knowledgeable children can equip themselves with epistemic resources to interpret their reality and effect change. Furthermore, it posits that environmental activism plays a crucial role as an epistemic resource for children, facilitating the expression of their ideas, challenging dominant narratives, and addressing environmental and social issues head-on. The article emphasises the transformative potential of activism as an epistemic resource, enabling substantive participation and empowering children to navigate and transcend such marginalised circumstances. In conclusion, it highlights how child environmental activism not only challenges the status quo but also provides children with crucial tools for their development as epistemic and social agents, promoting significant change in power dynamics and in the fight for social and environmental justice.
the postmodern turn in childhood studies and its pedagogical implications
Authors: Luo Yao
Published: September 2024

This paper reflects on the postmodern shift in childhood studies and its impact on education. As scholars interrogate the modern notion of childhood, the discourse of postmodernism has entered the realm of childhood studies, yielding various new perspectives on childhood. The key characteristics of the postmodern shift in childhood studies include: 1) the rejection of essentialism regarding childhood and the recognition of the diversity inherent in it; 2) the deconstruction of binary oppositions and the advocacy for the heterogeneous nature of childhood and the concept of "becoming-child"; 3) the dissolution of the modern subject associated with childhood and the reconstruction of the postmodern subject. Postmodern childhood studies will bring some positive impacts to the field of education, such as focusing on the differences among children rather than abstracting them into a unified map, removing adultism from education, and emphasizing the construction of new forms of child subjectivity in education. However, at the same time, it will also bring many challenges to education, such as questioning the essence of childhood and good education, shaking the foundation of educational existence brought by the dissolution of childhood, and the loss of educational significance due to the fluid and changing construction of child subjectivity. This underscores the importance of acknowledging that as education embraces the discourse of postmodern childhood, both its promises and perils will permeate the educational domain.
Devir-mundos em uma viagem pelas perguntas. Resenha do livro KOHAN, Walter Omar. A viagem dos sonhos impossíveis. Autêntica Editora: Belo Horizonte, 2022.
Authors: Alcalá vinagre Talita
Published: September 2024

A resenha apresenta e discute o livro de Walter Omar Kohan, A viagem dos sonhos impossíveis.
NAVEGANDO SOBRE A PLATAFORMA DO INSTAGRAM EM BUSCA DE “NÓS” E “ELOS” DAS REDES SOCIAIS DOS COLETIVOS DE JOVENS PERIFÉRICOS DE SALVADOR-BA
Authors: Bomfim Natanael Reis
Published: September 2024

Este estudo qualitativo, de caráter interpretativo/descritivo, teve como objetivo investigar a estrutura e as características das redes sociais formadas pelos jovens que constituem os coletivos das periferias urbanas, a fim de desvelar marcadores socioeducativos que conectam esses atores sociais. O estudo foi apoiado pela Teoria e Método das Representações Sociais (Jodelet, 2001; Moscovici, 1961) e na Teoria Social de Rede (Barnes, 1987; Lago Júnior, 2005). A investigação empírica foi desenvolvida com coletivos de jovens do Subúrbio Feroviário de Salvador, Bahia, Brasil, a partir de dados coletados dos pelo InstagramScraper e, no primeiro momento, essas informações foram tratadas pelo GEPHI/Cfinder e evidências pelo método de redes sociais. Em seguida, a análise do conteúdo do discurso foi realizada (Bardin, 2011) e os resultados apontaram conexões e práticas socioeducativas significativas para o processo formativo desses jovens na Educação em Periferias Urbanas.