bluuebunny/crossref_metadata_2025 huggingface dataset:
Research in the field of osteopathy: interest, methodology and perspectives
Authors: Véron Alice , Garet Martin , Bertholon Frédérique , Féval Patrick
Published: December 2019

There is a specifi c interest to the development of research in the osteopathic fi eld: fi rst in order to understand better its effects, then to continue to optimize its practice. To objectivise and quantify the effects of osteopathy would not only legitimate its practice but would also permit progression for the practitioners. These practitioners usually have a somewhat unclear notion of what research is. Firstly this article plans to describe the different types of studies of interest for the osteopathic fi eld, secondly to give an example of scientifi c process, including a step-by-step guide to the osteopath in devising his/her refl exion and building his/her project.
Osteopathic correction effect on anxiety and depression level according to HADS scale in children with various forms of epilepsy
Authors: Musina G. M. , Kushkov A. A. , Mukhin K. Ju.
Published: December 2019

Introduction.Epilepsy is a chronic brain disease, which treatment consists of relieving the seizures with the help of constant long-term use of anti-epileptic drugs. This, in turn, can cause various negative effects on the body. Epilepsy is not a single disease with various attacks, it is a whole spectrum associated with comorbid conditions, including anxiety and depression. Additional medication is suggested to correct this. Therefore, developing the effective drug-free methods with the help of osteopathic treatment to correct anxiety and depression in epilepsy complex therapy received priority.

Goal of research— to study the osteopathic treatment potential to reduce anxiety and depression levels in children with various forms of epilepsy.

Materials and methods.The study included 72 children with various forms of epilepsy, aged from 7 to 17 years, 35 girls, 37 boys. The selection criteria were as follows: at least 1 year of epilepsy course duration, no status or serial course of epileptic seizures, no motor and cognitive deteriorations, all children studied in public schools. All children received osteopathic treatment for 2 months, along with medical treatment. Before and after treatment, each patient′s anxiety and depression levels were assessed according to the Hospital Anxiety and Depression Scale (HADS), along with an osteopathic examination.

Results.All children taken in the study revealed a range of somatic dysfunctions of craniosacral system, skull and reciprocal tension membranes, with biomechanical abnormality. By initial testing, anxiety and depression average values according to HADS scale were above normal in all children. After osteopathic treatment, a statistically signifi cant decrease in anxiety and depression levels was found.

Conclusion. Osteopathic treatment is effi cient for epilepsy complex therapy in children. It helps to reduce drug load in correction of anxiety and depression that accompany the underlying disease.
Comparative researches of the quality indicators of the railway wheels of various methods of manufacture
Authors: Babachenko A. I. , Kononenko H. A. , Dementieva Zh. A. , Podolskyi R.V.
Published: December 2019

Methodology. To identify the macrostructure of the metal of the wheels, deep hot etching was performed with a 50% aqueous hydrochloric acid solution according to GOST 10243. An assessment of the contamination of the metal of the wheels under study was performed in accordance with GOST 1778. The microstructure was detected by etching in 4% alcoholic nitric acid solution. Tensile tests of steel rims and wheel disks were carried out in accordance with GOST 1497, hardness according to GOST 9012, impact strength was determined according to GOST 9454. The results of mechanical tests were checked for compliance with the requirements of DSTU GOST 10791: 2016 Findings. The macro and microstructures of cast and solid-rolled railway wheels were studied. It was established that due to the characteristics of the production of cast railway wheels (the wheel rim crystallizes, feeding on liquid metal through a disk, then the disk and hub crystallize), all three zones that are observed in a steel ingot (a zone of fine-grained crust, columnar crystals and equiaxial crystals) are observed and in each element of the cast railway wheel. In the metal of the rim of the cast wheel, the average score of sulfides is 3 points, which does not meet the requirements of GOST 10791: 2016, and the sulfide inclusions in the whole-rolled railway wheel do not exceed 2 on the C scale of GOST 1778-70. It is shown that the microstructure of a cast railway wheel consists of perlite, has a heterogeneous structure (strongly and weakly treated strips), the formation of which is explained by the presence of dendritic segregation, which occurs in the process of crystallization. In the solid-rolled wheel, segregation heterogeneity is weakly expressed, the microstructure is ferritic-pearlitic, homogeneous. The cast wheels of class C according to the strength properties satisfy the requirements of DSTU GOST 10791: 2016 for wheels made of steel grade T, but do not meet the requirements for plastic and viscous characteristics. Originality. The influence of the production method (casting, hot plastic deformation) on the quality indicators of railway wheels has been established. Practical value. Since the metal of a cast railway wheel of class C has low values of reliability indicators, the use of cast railway wheels is possible, apparently, only on closed routes with special operating conditions. Keywords: cast railway wheels, all-rolled railway wheels, microstructure, macrostructure, crystallization, properties.
Features of the current state of development of pipeline enterprises containing the "Ukrtruboprom" association
Authors: Ksaverchuk L. P. , Grynev A. F. , Korol R. M. , Myronenko M. A.
Published: December 2019

Purpose. Analysis of the development of metallurgical pipe enterprises of Ukraine, which are under the auspices of the association "Ukrtruboprom" at the beginning of 2019. A clear demonstration of trends in the development of the metallurgical industry in our country. Justification of proposals for a set of measures to overcome the negative trends in the pipe industry of Ukraine.
The technique. When writing the article, a comparative analysis method was used to substantiate recommendations for overcoming negative phenomena in the pipe industry in Ukraine.
Results. The article shows the dynamics of the development of the pipe industry in the country over the past year, with an emphasis on the domestic market. Recommendations for overcoming the negative trend of development of metallurgical enterprises, which are under the auspices of the association "Ukrtruboprom", in particular in the domestic market, are presented. The importance of introducing an automatic value added tax reimbursement system for exporting enterprises, as well as increasing the level of wages at pipe enterprises in Ukraine, was emphasized.
Scientific novelty. The importance of the practical application of methods of control theory, in particular, the method of comparative analysis, was confirmed. This made it possible to formulate a series of step-by-step measures aimed at a comprehensive solution to the problems existing in the domestic pipe industry in Ukraine.
Practical value. The information presented in this article will be of interest to a wide range of researchers and practitioners who are interested in the general trend of the development of pipe enterprises in Ukraine. Understanding the depth of the problems of domestic consumption of metal products in modern Ukraine is the first step towards solving them in the future.
Keywords: association of enterprises "Ukrtruboprom", pipe production, management, development, internal and external markets for products
Conhecimento nutricional e uso de suplementos alimentares por frequentadores de academias de uma capital do nordeste
Authors: Soares Jarlson Pio , Da Costa Ana Caroline Pereira , Costa Gilberto de Araújo , De Carvalho Luiza Marly Freitas , Landim Liegy Agnes dos Santos Raposo
Published: December 2019

Objetivo: Investigar o conhecimento nutricional e a prevalência do uso de suplementos alimentares por frequentadores de academias de uma capital do Nordeste. Métodos: Trata-se de um estudo transversal e quantitativo, com a participação de 68 indiví­duos, de ambos os sexos e maiores de 18 anos. Aplicou-se questionário referente ao conhecimento dos alimentos, suplementos alimentares e a fonte de informação desses suplementos. Resultados: Verificou-se que 52,94% (n=36) não apresentaram conhecimento sobre a função dos macronutrientes. Em relação ao uso dos suplementos alimentares, 51,48% (n=35) relataram não usar ou já ter feito uso. O whey protein aparece como o suplemento mais utilizado, citado por 26,75% (n=23) dos indiví­duos. A internet aparece como a maior fonte de informação sobre suplementos com 38,32% (n=41). Conclusão: Conclui-se que há pouco conhecimento quanto aos macronutrientes e suas funções. Além disso, observou-se que a maioria das informações referentes ao uso de suplementos não estão sendo adquiridas por um profissional habilitado, entendendo-se que o uso está sendo feito de forma indiscriminada, sendo necessária uma intervenção em nutrição esportiva nas academias.Palavras-chave: nutrição, suplementos alimentares, academias.
Australian Meningococcal Surveillance Programme annual report, 2017
Authors: Lahra Monica M , Enriquez Rodney , George CR Robert
Published: December 2019

In 2017, there were 374 laboratory-confirmed cases of invasive meningococcal disease (IMD) analysed by the Australian National Neisseria Network. This was the highest number of laboratory-confirmed cases since 2003. Probable and confirmed cases of IMD are notifiable in Australia; there were 379 IMD cases notified to the National Notifiable Diseases Surveillance System in 2017, the highest number reported since 2005. Meningococcal sero-grouping was determined for 98% (367/374) of laboratory-confirmed IMD cases. Serogroup B infections accounted for 137 cases (37%). The number of serogroup W infections (141 cases, 38%) in 2017 was the highest since the Australian Meningococcal Surveillance Programme (AMSP) began. In addition, the number and proportion of serogroup Y infections (75 cases, 20%) was also the highest recorded by the AMSP. Molecular typing results were available for 315 of the 374 IMD cases (83%). Of the serogroup W IMD strains that were able to be genotyped, 97% (125/129) had the PorA antigen encoding gene type P1.5,2 and of these, 59% (74/125) were sequence type 11, the same type as the hypervirulent serogroup W strain that has been circulating in the UK and South America since 2009. The primary IMD age peak was observed in adults aged 45 years or more, whilst secondary disease peaks were observed in those aged less than 5 years. Serogroup B infections predominated in the age group 15–19 years. Serogroup W infections predominated in those aged 65 years or more. Serogroup Y infections were predominately seen in adults aged 45 years or more. Of the IMD isolates tested for antimicrobial susceptibility, 5.1% (14/276) were resistant to penicillin; decreased susceptibility to penicillin was observed in a further 89% (247/276) of isolates. All isolates tested were susceptible to ceftriaxone; two isolates were less susceptible to ciprofloxacin; and one isolate was resistant to rifampicin.
Crónica de la Asamblea Parlamentaria del Consejo de Europa (junio-septiembre 2002)
Authors: Stoffel Vallotton Nicole
Published: December 2019

SUMARIO: Introducción. -1. Cuestiones Políticas. Países no miembros. - II. Derechos Humanos. - III. Cuestiones Jurídicas y Penales. - IV. Economía, Agricultura y Alimentación. - V. Cuestiones sociales y de sanidad. - VI. Educación, Ciencia, Tecnología y Cultura. - VIL Medio Ambiente y Administración Local. - VIII. Población, Refugiados, Formación Profesional. - IX. Cuestiones administrativas y reglas de procedimiento.
Cuenca Toribio, José Manuel y Miranda García, Soledad: «El poder y sus hombres: ¿por quiénes hemos sido gobernados los españoles? (1705-1998)» (Recensión)
Authors: Navarro García Luis
Published: December 2019

Recensión de la obra: Cuenca Toribio, José Manuel y Miranda García, Soledad. El poder y sus hombres: ¿por quiénes hemos sido gobernados los españoles? (1705-1998). Madrid, Actas, 1998, 894 págs.
Crónica del Comité de Ministros del Consejo de Europa (Junio-septiembre de 2003)
Authors: Torres Ugena Nila
Published: December 2019

SUMARIO: Introducción. – I. Cuestiones políticas. Países no miembros. – II. Derechos Humanos. – III. Cuestiones Jurídicas y Penales. – IV. Economía, Agricultura y Alimentación. – V. Cuestiones sociales y de sanidad. – VI. Educación, Ciencia, Tecnología y Cultura. – VII. Medio Ambiente y Administración Local. – VIII. Población, Refugiados, Formación Profesional. – IX. Cuestiones administrativas y reglas de procedimiento.
Pegoraro, Lucio e Porras Nadales, A.J. (a cura di): «Qualità formativa e tecnica legislativa. Europa, Stati, enti territoriali» (Recensión)
Authors: Jimena Quesada Luis
Published: December 2019

Recensión de la obra: Pegoraro, Lucio, e Porras Nadales, Antonio J. (a cura di): Qualità normativa e tecnica legislativa. Europa, Stati, enti territoriali/Calidad normativa y técnica Legislativa. Europa, Estados y entes infraestatales, Bologna, Libreria Bonomo Editrice, 2003, 274 páginas
Crónica del Comité de Ministros del Consejo de Europa (octubre-diciembre de 2003)
Authors: Torres Ugena Nila
Published: December 2019

SUMARIO: Introducción. -1. Cuestiones Políticas. Países no miembros. - II. Derechos humanos. -III. Cuestiones jurídicas y penales. - IV. Economía, Agricultura y Alimentación. - V. Cuestiones Sociales y de Sanidad. - VI. Educación, Ciencia, Tecnología y Cultura. -VIL Medio Ambiente y Administración Local. - VIII. Población, Refugiados, Formación Profesional. - IX. Cuestiones Administrativas y Reglas de Procedimiento.
La ponencia en el procedimiento legislativo en las Cortes Generales
Authors: García-Escudero Márquez Piedad
Published: December 2019

SUMARIO: I. Origen de la ponencia. Modelos en derecho comparado. A) Derecho histórico. B) Derecho comparado. - II. La ponencia en el procedimiento legislativo en las cortes generales. A) Regulación. B) Naturaleza. Caracteres. 1. Órgano colegiado. 2. Órgano constituido en el seno de las comisiones permanentes legislativas. 3. Su función en el procedimiento legislativo es preparar el trabajo de la Comisión. C) Composición. Designación. 1. Composición, a) En el Congreso de los Diputados, b) En el Senado. 2. Designación, a) En el Congreso de los Diputados, b) En el Senado, c) Criterios para la designación. D) Funcionamiento. 1. Carácter acéfalo. 2. Carácter informal y no público de sus reuniones. 3. Lugar y tiempo de sus reuniones. 4. Adopción de acuerdos mediante voto ponderado. 5. Asesoramiento por los Letrados de las Cortes Generales. E) Funciones. 1. En el Congreso de los Diputados, a) Previstas en el Reglamento. a.1) Elaboración del informe. a.2) Calificación de enmiendas financieras. a.3) Emisión de criterio sobre la naturaleza orgánica de iniciativas legislativas y enmiendas. a.4) Actuación en la elaboración y reforma de Estatutos de Autonomía, b) En la realidad: crítica y defensa. Elaboración del informe. 2. En el Senado, a) Elaboración del informe, b) Función de propuesta durante el debate en la Comisión. - III. El Informe de la ponencia. A) Estructura. Contenido. B) Destino del informe. Efectos. 1. Remisión a la Comisión, a) En el Congreso de los Diputados. b) En el Senado. 2. Texto base para el debate en la Comisión. - IV. Perspectivas de reforma. A) Propuestas de la doctrina. 1. Ponente unipersonal. 2. Experto designado por el Gobierno. 3. Audiencia de expertos y grupos de interés. B) Propuesta posibilista.
Consideraciones sobre la historiografía española de la segunda mitad del siglo XX ante el advenimiento de la Revolución Liberal: tres "Cádices" que pueden ser más
Authors: Estrada Michel Rafael
Published: December 2019

Estudio sobre: Consideraciones sobre la historiografía española de la segunda mitad del siglo XX ante el advenimiento de la Revolución Liberal: tres "Cádices" que pueden ser más
Cuenca Toribio, José Manuel: «Catolicismo social y político en la España contemporánea (1870-2000)» (Recensión)
Authors: López Mora Fernando
Published: December 2019

Recensión de la obra: Cuenca Toribio, José Manuel: Catolicismo social y político en la España contemporánea (1870-2000), Unión Editorial, Madrid, 2003,451 pp.
Gidding, P.: «The future of Parliament. Issues for a new century» (Recensión)
Authors: Delgado-Iribarren García-Campero Manuel
Published: December 2019

Recensión sobre la obra: Gidding, P.: The future of Parliament. Issues for a new century, Palgrave Macmillan, Nueva York, 2005, pp. 287
Crónica de la Asamblea Parlamentaria del Consejo de Europa: julio a diciembre 2004
Authors: Stoffel Vallotton Nicole
Published: December 2019

SUMARIO: I. Cuestiones políticas. Países no miembros II. Derechos Humanos. III. Cuestiones jurídicas y penales. I V. Economia, desarrollo y alimentación. V. Cuestiones sociales y de sanidad. VI. Educación, ciencia, tecnología y cultura. VII. Medio ambiente, agricultura y administración local. VIII. Población, refugiados, formación profesional. IX. Cuestiones administrativas y reglas de procedimiento.
IPEX: estado de la cuestión
Authors: Fuentes Josefa , Gonzalo Miguel Ángel
Published: December 2019

Proyecto IPEX sobre el estado de la cuestión
Las Cortes de la Segunda República: ¿un Parlamento de partidos?
Authors: Álvarez Tardío Manuel
Published: December 2019

SUMARIO: Introducción. 1.- Discontinuidad y Fragmentación en una Historia Breve. 2.- La Centralidad de un Parlamento Nuevo. 3.-Los Grupos Parlamentarios. Algunas Conclusiones
El Pleno de las Cámaras: notas, funcionamiento y competencias
Authors: García-Escudero Márquez Piedad
Published: December 2019

Notas sobre el funcionamiento y competencias del Pleno de las Cámaras
El laicismo de la Teoría de la Ley de Marsilio de Padua
Authors: Bayona Aznar Bernardo
Published: December 2019

SUMARIO: 1. Definición marsiliana de ley. 2. La figura del legislador. 3. El procedimiento legislativo. 4. Carácter laico de la ley. 4.1. Diferencias entre la ley divina y la humana. 4.2. El rechazo de la ley natural. 5. La encarnación del legislador en la VALENTIOR PARS.
Informe del Letrado Mayor de las Cortes Generales sobre el procedimiento para la renovación de los Vocales del Consejo General del Poder Judicial
Authors: Alba Navarro Manuel
Published: December 2019

Informe sobre el procedimiento para la renovación de los Vocales del Consejo General del Poder Judicial
Associations among temperature, sea ice and phytoplankton bloom dynamics in the Barents Sea
Authors: Dong K , Kvile ØK , Stenseth NC , Stige LC
Published: December 2019

Variations in physical conditions caused by climate change are likely to have large influences on marine organisms, including phytoplankton. Here, we investigated associations between satellite-derived chlorophyll a data from the Barents Sea and 2 key abiotic factors: sea surface temperature and sea-ice concentration. Specifically, we investigated how climate variability, through the measured physical factors, associated with phytoplankton phenology between 1998 and 2014. Associations between sea surface temperature and phytoplankton bloom dynamics differed depending on the area. The spring phytoplankton bloom occurred earlier and had higher magnitude in warm compared to cold years in the northern part of the Barents Sea, but there was no significant association in the southern part. In seasonally ice-covered regions, the association between the timing of the sea-ice retreat and the phytoplankton peak was nonlinear: sea-ice retreat time before mid-May was not associated with bloom timing, whereas the phytoplankton bloom occurred before or immediately following the ice retreat when the ice retreated after mid-May. Although drivers that are relatively constant across years, such as insolation, probably influenced the spatial gradient in chlorophyll, a space-for-time substitution captured the predicted effects of sea-ice retreat on the timing and magnitude of the phytoplankton bloom quite well.
Effect of Antidiabetic Treatment on Bone
Authors: JACKULIAK J. , KUŽMA M. , PAYER J.
Published: December 2019

Patients with diabetes mellitus are at an increased risk of bone fractures. Several groups of effective antidiabetic drugs are available, which are very often given in combination. The effects of these medications on bone metabolism and fracture risk must not be neglected. Commonly used antidiabetic drugs might have a positive, neutral or negative impact on skeletal health. Increased risk of fracture has been identified with use of thiazolidinediones, most definitively in women. Also treatment with sulfonylureas can have adverse effects on bone. One consequence of these findings has been greater attention to fracture outcomes in trails of new diabetes medication (incretins and SGLT-2 inhibitors). The effect of insulin on bone is discussed and the risk of fractures in patients using insulin seems to be unrelated to insulin as itself. The aim of the review is to summarize effects of antidiabetic treatment on bone – bone mineral density, fractures and bone turnover markers. The authors also try to recommend a strategy how to treat patients with diabetes mellitus regarding the risk of osteoporotic fractures. In this review the problem of how to treat osteoporosis in patient with diabetes is also discussed.
Prevalence and Risk Factors for Drug-Induced Liver Injury Among Patients With Rheumatic Diseases Treated With Biological Therapy: A Single-Center Experience
Authors: BRAZDILOVA K. , KOLLER T. , KILLINGER Z. , PAYER J.
Published: December 2019

Drug-induced liver injury (DILI) is a common event in patients with rheumatic diseases (RD) on biological therapy (BT). We aimed at evaluating the prevalence and pattern of DILI. Consecutive RD patients treated with BT were followed for 6 months. ALT and ALP >the upper limit normal (ULN) and3xULN injury Grade 2. 582 liver function tests (LFTs) in 199 patients were evaluated, median age 53y, 59.3 % females, RA in 108, AS 49, and PsA 42 patients. ALT Grade 1 elevation was observed in 25.6 %, transient in 18.6 %, persisting in 7 %, Grade 2 in 1.5 %, ALP Grade 1 in 3.5 %, transient in 2 %, persisting in 1.5 %. We report no case of ALP Grade 2 or Hy´s law (ALT>3xULN, bilirubin>2xULN). Patients with persisting ALT elevation had higher BMI (28.23 vs. 25.74, p=0.016), lower DAS28 (2.22 vs. 5.28, p=0.046). ALT Grade 1 injury was more frequent with solo tocilizumab compared with other agents (27.5 % vs. 13.6 %, p=0.01). DILI was frequent, in 18.6 % transient, in 7 % persisting, Grade 2 in 1.5 %, led to treatment alteration in 0.5 %, with higher prevalence on solo tocilizumab therapy. We report no new safety signals for BT in RD.
The PI3k/Akt Pathway Is Associated With Angiogenesis, Oxidative Stress and Survival of Mesenchymal Stem Cells in Pathophysiologic Condition in Ischemia
Authors: SAMAKOVA A. , GAZOVA A. , SABOVA N. , VALASKOVA S. , JURIKOVA M. , KYSELOVIC J.
Published: December 2019

Ischemic diseases are characterized by reduced blood supply to a tissue or an organ due to obstruction of blood vessels. The most serious and most common ischemic diseases include ischemic heart disease, ischemic stroke, and critical limb ischemia. Revascularization is the first choice of therapy, but the cell therapy is being introduced as a possible way of treatment for no-option patients. One of the possibilities of cell therapy is the use of mesenchymal stem cells (MSCs). MSCs are easily isolated from bone marrow and can be defined as non-hematopoietic multipotent adult stem cells population with a defined capacity for self-renewal and differentiation into cell types of all three germ layers depending on their origin. Since 1974, when Friedenstein and coworkers (Friedenstein et al. 1974) first time isolated and characterized MSCs, MSC-based therapy has been shown to be safe and effective. Nevertheless, many scientists and clinical researchers want to improve the success of MSCs in regenerative therapy. The secret of successful cell therapy may lie, along with the homing, in secretion of biologically active molecules including cytokines, growth factors, and chemokines known as MSCs secretome. One of the intracellular signalling mechanism includes the activity of phosphatidylinositol-3-kinase (phosphoinositide 3-kinase) (PI3K) - protein kinase B (serine-threonine protein kinase Akt) (Akt) pathway. This PI3K/Akt pathway plays key roles in many cell types in regulating cell proliferation, differentiation, apoptosis, and migration. Pre-conditioning of MSCs could improve efficacy of signalling mechanism.
ÇOCUKLUK DÖNEMİNDE GÖRÜLEN DUYGUSAL VE DAVRANIŞSAL SORUNLARLA İLGİLİ TÜRKİYE’DE YAPILAN LİSANSÜSTÜ TEZLERİN İNCELENMESİ
Authors: AYANOĞLU Mine , BOĞA Ebru , KAY Mehmet Akif , İNCİ Ramazan , TARKOÇİN Suna , KAÇMAZ Cihangir , TEMİZ Ahmet , GÖĞEBAKAN Şahin
Published: December 2019

Bu çalışmanın
amacı, duygusal ve davranışsal sorunlarla ilgili Türkiye’de yapılan lisansüstü
tezlerin incelenmesidir. Araştırmada nicel araştırma yöntemlerinden betimsel
tarama modeli kullanılmıştır. Araştırmanın örneklemini Yüksek Öğretim Kurumu
Ulusal Tez Merkezi internet sitesinden ulaşılan 145 yüksek lisans, doktora ve
tıpta uzmanlık tezleri oluşturmaktadır. Araştırmada veri toplama aracı olarak,  araştırmacılar tarafından araştırmanın
amacına uygun olarak hazırlanan veri toplama formu oluşturulmuştur. İncelenen
tezler, veri toplama formunda yer alan sorular doğrultusunda incelenmiş, elde
edilen verilerin frekans ve yüzdeleri analiz edilmiştir. Araştırma sonucunda duygusal
ve davranışsal sorunları içeren en fazla çalışmanın tıpta uzmanlık tezi
(%44.83) olduğu; yıllara göre bakıldığında en fazla 2000-2009 yılları arasında
(%41) çalışma yapıldığı saptanmıştır. Çalışma gruplarına bakıldığında en fazla
farklı yaş grubundaki çocuklar (%39.31) üzerinde çalışmaların yapıldığı;
lisansüstü çalışmalarında en fazla amaçsal örnekleme tekniğinin (%58.62)
kullanıldığı görülmüştür.  Hastalık
türü/çalışılan sorun türüne göre en fazla birden fazla bozukluk türünü aynı
anda çalışılan (%50.34) lisansüstü tezlere rastlanmıştır. İncelenen lisansüstü
tezlerin çoğunlukla tam metin (%79.31) olarak ulaşıldığı; anabilim dalları
incelendiğinde duygusal ve davranışsal sorunlarla ilgili lisansüstü
çalışmaların çoğunluğunun Çocuk Ruh Sağlığı/Çocuk Ergen Ruh Sağlığı ve
Hastalıkları anabilim dalında (%30.34) 
yayınlandığı tespit edilmiştir. İncelenen lisansüstü tezlerde model ve
desen olarak en fazla betimsel model (%42.76) çalışıldığı; yöntemine
bakıldığındaysa en fazla nicel araştırma yönteminin (%67.59) kullanıldığı
görülmüştür.
Influence of Licorice Root Feeding on Chemical-Nutritional Quality of Cow Milk and Stracciata Cheese, an Italian Traditional Fresh Dairy Product
Authors: Bennato Francesca , Ianni Andrea , Innosa Denise , Martino Camillo , Grotta Lisa , Pomilio Francesco , Verna Micaela , Martino Giuseppe
Published: December 2019

The aim of this study was to evaluate the effect of dietary licorice root supplementation on chemical and nutritional characteristics of cow milk and Stracciata cheese. Licorice did not influence milk and Stracciata fat content but induced modifications in fatty acid profile. Both in milk and Stracciata, a decrease in saturated fatty acids was detected and in cheeses an increase of monounsaturated and polyunsaturated fatty acids was observed. Stracciata obtained from the experimental group showed an improved oxidative stability after six days of ripening, a finding partly justifiable by the well-known richness of antioxidant compounds in the licorice root. The volatile profile of Stracciata was also affected by dietary licorice intake, with an increase in esters and a reduction of aldehydes and ketones. These results suggest a positive role of licorice in modifying chemical and physical properties of cow cheeses, reducing lipid oxidation and inducing changes in color and flavor with a presumable improvement in consumer acceptability.
Engineering Requirements of a Herpes Simplex Virus Patient Registry: Discovery Phase of a Real-World Evidence Platform to Advance Pharmacogenomics and Personalized Medicine
Authors: Surodina Svitlana , Lam Ching , de Cock Caroline , van Velthoven Michelle , Milne-Ives Madison , Meinert Edward
Published: December 2019

Comprehensive pharmacogenomic understanding requires both robust genomic and demographic data. Patient registries present an opportunity to collect large amounts of robust, patient-level data. Pharmacogenomic advancement in the treatment of infectious diseases is yet to be fully realised. Herpes simplex virus (HSV) is one disease for which pharmacogenomic understanding is wanting. This paper aims to understand the key factors that impact data collection quality for medical registries and suggest potential design features of an HSV medical registry to overcome current constraints and allow for this data to be used as a complement to genomic and clinical data to further the treatment of HSV. This paper outlines the discovery phase for the development of an HSV registry with the aim of learning about the users and their contexts, the technological constraints and the potential improvements that can be made. The design requirements and user stories for the HSV registry have been identified for further alpha phase development. The current landscape of HSV research and patient registry development were discussed. Through the analysis of the current state of the art and thematic user analysis, potential design features were elucidated to facilitate the collection of high-quality, robust patient-level data which could contribute to advances in pharmacogenomic understanding and personalised medicine in HSV. The user requirements specification for the development of an HSV registry has been summarised and implementation strategies for the alpha phase discussed.
How Decisiveness, Self-Efficacy, Curiosity and Independent and Interdependent Self-Construals Are Related to Future Hopefulness among Senior Students
Authors: Öztekin Hakan Remzi , Bayraktar Fatih
Published: December 2019

Hope is a future-oriented reasoning that influences psychological assets of individuals. A hopeful standing towards the future can positively influence individual well-being. Different standings in terms of hopefulness may create variations in psychological assets of people. In the current study, we examined the associations of decisiveness, self-efficacy, curiosity and self-construals with hopefulness. A total of 278 senior university students were recruited for the study from Eastern Mediterranean University in Famagusta, North Cyprus. Participants filled six questionnaires; the Beck Hopelessness Scale, the Independent and Interdependent Self-Construal Scale, Multi-Domain Decisiveness Scale, Curiosity and Exploration Inventory II, the Dispositional Hope Scale and the General Self-Efficacy Scale. The data was analyzed by hierarchical multiple regression analysis on SPSS 23 software program. The results indicated that self-efficacy and decisiveness significantly predicted hopefulness, while curiosity did not predict hopefulness and only independent self-construal had the predictive effect on hopefulness. Based on these findings, the emerging adulthood nature of the study sample was discussed, and further recommendations were presented.
Tumor Suppressor Function of miR-127-3p and miR-376a-3p in Osteosarcoma Cells
Authors: Fellenberg Joerg , Lehner Burkhard , Saehr Heiner , Schenker Astrid , Kunz Pierre
Published: December 2019

Since the introduction of high-dose chemotherapy about 35 years ago, survival rates of osteosarcoma patients have not been significantly improved. New therapeutic strategies replacing or complementing conventional chemotherapy are therefore urgently required. MicroRNAs represent promising targets for such new therapies, as they are involved in the pathology of multiple types of cancer, and aberrant expression of several miRNAs has already been shown in osteosarcoma. In this study, we identified silencing of miR-127-3p and miR-376a-3p in osteosarcoma cell lines and tissues and investigated their role as potential tumor suppressors in vitro and in vivo. Transfection of osteosarcoma cells (n = 6) with miR-127-3p and miR-376a-3p mimics significantly inhibited proliferation and reduced the colony formation capacity of these cells. In contrast, we could not detect any influence of miRNA restoration on cell cycle and apoptosis induction. The effects of candidate miRNA restoration on tumor engraftment and growth in vivo were analyzed using a chicken chorioallantoic membrane (CAM) assay. Cells transfected with mir-127-3p and miR-376a-3p showed reduced tumor take rates and tumor volumes and a significant decrease of the cumulative tumor volumes to 41% and 54% compared to wildtype cells. The observed tumor suppressor function of both analyzed miRNAs indicates these miRNAs as potentially valuable targets for the development of new therapeutic strategies for the treatment of osteosarcoma.
Inhibitor of DNA-Binding Protein 4 Suppresses Cancer Metastasis through the Regulation of Epithelial Mesenchymal Transition in Lung Adenocarcinoma
Authors: Wang Chi-Chung , Hsu Yuan-Ling , Chang Chi-Jen , Wang Chia-Jen , Hsiao Tzu-Hung , Pan Szu-Hua
Published: December 2019

Metastasis is a predominant cause of cancer death and the major challenge in treating lung adenocarcinoma (LADC). Therefore, exploring new metastasis-related genes and their action mechanisms may provide new insights for developing a new combative approach to treat lung cancer. Previously, our research team discovered that the expression of the inhibitor of DNA binding 4 (Id4) was inversely related to cell invasiveness in LADC cells by cDNA microarray screening. However, the functional role of Id4 and its mechanism of action in lung cancer metastasis remain unclear. In this study, we report that the expression of Id4 could attenuate cell migration and invasion in vitro and cancer metastasis in vivo. Detailed analyses indicated that Id4 could promote E-cadherin expression through the binding of Slug, cause the occurrence of mesenchymal-epithelial transition (MET), and inhibit cancer metastasis. Moreover, the examination of the gene expression database (GSE31210) also revealed that high-level expression of Id4/E-cadherin and low-level expression of Slug were associated with a better clinical outcome in LADC patients. In summary, Id4 may act as a metastatic suppressor, which could not only be used as an independent predictor but also serve as a potential therapeutic for LADC treatment.
Immunotherapy in Pediatric Solid Tumors—A Systematic Review
Authors: Marayati Raoud , Quinn Colin H. , Beierle Elizabeth A.
Published: December 2019

Despite advances in the treatment of many pediatric solid tumors, children with aggressive and high-risk disease continue to have a dismal prognosis. For those presenting with metastatic or recurrent disease, multiple rounds of intensified chemotherapy and radiation are the typical course of action, but more often than not, this fails to control the progression of the disease. Thus, new therapeutics are desperately needed to improve the outcomes for these children. Recent advances in our understanding of both the immune system’s biology and its interaction with tumors have led to the development of novel immunotherapeutics as alternative treatment options for these aggressive malignancies. Immunotherapeutic approaches have shown promising results for pediatric solid tumors in early clinical trials, but challenges remain concerning safety and anti-tumor efficacy. In this review, we aim to discuss and summarize the main classes of immunotherapeutics used to treat pediatric solid tumors.
Shapes Control of Bi2WO6 Nano-Structures as Photo-Fenton Catalysts for Pulping Wastewater Treatment
Authors: Ran Miao , Zou Xiuxiu , Tian Qingwen , Liang Long , Wu Ting , Pan Aixiang , Deng Yongjun , Fang Guigan , Ding Laibao
Published: December 2019

Bi2WO6 assembled by flower-like microspheres and nanosheets were controllably synthesized through a one-step hydrothermal approach. Multiple technologies, including X-ray powder diffraction (XRD), scanning electron microscopy (SEM), and UV–Vis diffuse reflectance spectrum (UV–Vis), were carried out to characterize the as-synthesized samples. The photocatalytic efficiency of Bi2WO6 synthesized with a series of temperature and pH values shows different morphologies and photocatalytic properties. The photocatalyst (Bi2WO6) synthesized at 220 °C and pH of 7 exhibited the best photocatalytic performance, with the methylene blue (MB) degradation approaching 91.6% after reaction time of 60 min. Free radical capture experiments indicate that •OH is the primary reactive species in the methylene blue (MB) degradation reaction, h+ and •O2− contribute negligible influence, while the addition of H2O2 significantly improves the photocatalytic activity of Bi2WO6. Biodegraded poplar preconditioning refiner chemical alkaline peroxide mechanical pulp wastewater (PPW) was treated over Bi2WO6 under UV light (Bi2WO6/UV/H2O2); chemical oxygen demand (CODCr) and color degradation rate were 85.8% and 92.0%, respectively. These results show that Bi2WO6 semiconductors can be introduced as an efficient and stable photocatalyst for industry wastewater treatment.
Knock Down of Plakophillin 2 Dysregulates Adhesion Pathway through Upregulation of miR200b and Alters the Mechanical Properties in Cardiac Cells
Authors: Puzzi Luca , Borin Daniele , Gurha Priyatansh , Lombardi Raffaella , Martinelli Valentina , Weiss Marek , Andolfi Laura , Lazzarino Marco , Mestroni Luisa , Marian Ali J. , Sbaizero Orfeo
Published: December 2019

Background: Mutations in genes encoding intercalated disk/desmosome proteins, such as plakophilin 2 (PKP2), cause arrhythmogenic cardiomyopathy (ACM). Desmosomes are responsible for myocyte–myocyte attachment and maintaining mechanical integrity of the myocardium. Methods: We knocked down Pkp2 in HL-1 mouse atrial cardiomyocytes (HL-1Pkp2-shRNA) and characterized their biomechanical properties. Gene expression was analyzed by RNA-Sequencing, microarray, and qPCR. Immunofluorescence was used to detect changes in cytoskeleton and focal adhesion. Antagomirs were used to knock down expression of selected microRNA (miR) in the rescue experiments. Results: Knockdown of Pkp2 was associated with decreased cardiomyocyte stiffness and work of detachment, and increased plasticity index. Altered mechanical properties were associated with impaired actin cytoskeleton in HL-1Pkp2-shRNA cells. Analysis of differentially expressed genes identified focal adhesion and actin cytoskeleton amongst the most dysregulated pathways, and miR200 family (a, b, and 429) as the most upregulated miRs in HL-1Pkp2-shRNA cells. Knockdown of miR-200b but not miR-200a, miR-429, by sequence-specific shRNAs partially rescued integrin-α1 (Itga1) levels, actin organization, cell adhesion (on collagen), and stiffness. Conclusions: PKP2 deficiency alters cardiomyocytes adhesion through a mechanism that involves upregulation of miR-200b and suppression of Itga1 expression. These findings provide new insights into the molecular basis of altered mechanosensing in ACM.
The Excitation of Ultrasound by Laser Radiation in Water Using an Optical Fiber Laser Converter with a 2D Colloidal Crystalline Coating
Authors: Bredikhin Vladimir I. , Kazakov Viacheslav V.
Published: December 2019

The technology of applying a colloidal single-layer coating of transparent polystyrene (PS) Ø 1 μm spheres at the tip face of a quartz fiber has been proposed and tested. Such a coating plays, in a light absorbing liquid, the role of a converter of pulsed laser radiation into acoustic radiation. The generation of ultrasound in water using a converter based on a quartz fiber 1 mm in diameter with a 2D colloidal crystalline coating consisted of polystyrene spheres with a diameter of ~1 μm at the fiber end was investigated. When excited by laser radiation (λ = 1.064 µm), coating of polystyrene spheres created in the liquid a laser thermal microstructure with a characteristic size of fractions of ~λ and a maximum temperature up to 10−2 degree at an energy in a short laser pulse of ~0.005 J. This short-lived thermal microstructure generated sound pulses in the liquid in the approximately 0.2–4 MHz range. The results of the experimental study of this effect are reported. The proposed laser radiation converter with colloidal coating of the optical fiber distal tip by a single layer of transparent spheres can be used for the development of new laser microtools for studying, processing of various objects in microsurgery, microstructuring of the surface, spot cleaning and restoration of objects of art and history.
Self-Cleaning Nanoscale Coating for the Separation of Oil–Water Mixture
Authors: Shervani Suboohi , Ling Jingjing , Liu Jiabin , Husain Tahir
Published: December 2019

The current study pertains to the self-cleaning nanoscale coating of graphene/polymer nanohybrid system for the separation of oil–water mixture. Using a single nanohybrid system, we have developed a two-stage process for the selective removal of the hydrocarbons. Total petroleum hydrocarbons (TPHs) and separation efficiency are determined by gas chromatography-flame ionization detector (GC-FID). Analysis of the polycyclic aromatic hydrocarbons (PAHs) in the two stage samples is carried out by using gas chromatography coupled to mass spectrometry (GC-MS). The analysis shows the reduction in TPHs from 290 ppm to less than 1 ppm and more than 99.5% separation efficiency (oil removal from oil–water mixture) is achieved. No polycyclic aromatic hydrocarbons (PAHs) were detected in the treated water.
Preparation and Performance Test of the Super-Hydrophobic Polyurethane Coating Based on Waste Cooking Oil
Authors: Cheng Yingmo , Miao Dejun , Kong Lingxiao , Jiang Jiachen , Guo Zhenxing
Published: December 2019

In order to solve the problem of dust accumulation on the fin surface of a mine air cooler, a method of preparing super-hydrophobic polyurethane (SPU) coating based on waste cooking oil (WCO) was proposed. Firstly, the polyurethane prepolymer was synthesized with WCO as a raw material, and then the polyurethane prepolymer was modified with amino-terminated polydimethylsiloxane (ATP) to obtain SPU emulsion. The chemical structure and thermal stability of SPU were characterized by infrared spectrum and thermogravimetric analysis. A series of nanocomposites were prepared by combining modified silicon carbide (APT-SiC) particles and SPU emulsions. According to the parameters of pull-off strength, contact angle, sliding angle and thermal conductivity, the filler ratio of nanocomposites was optimized. The test results show that when the content of APT-SiC particles is 20 wt %, super-hydrophobic polyurethane coating can be obtained. The coating has good pull- off strength and thermal conductivity, and the contact angle and sliding angle are 161° and 3°, respectively. In addition, the practical application of the super-hydrophobic polyurethane coating was tested by related experiments. The experimental results show that the coating has good self-cleaning, wear resistance and anti-corrosion performance, can meet the requirements of air coolers in special environments, and has great application prospects.
Generalized Binary Time Series Models
Authors: Jentsch Carsten , Reichmann Lena
Published: December 2019

The serial dependence of categorical data is commonly described using Markovian models. Such models are very flexible, but they can suffer from a huge number of parameters if the state space or the model order becomes large. To address the problem of a large number of model parameters, the class of (new) discrete autoregressive moving-average (NDARMA) models has been proposed as a parsimonious alternative to Markov models. However, NDARMA models do not allow any negative model parameters, which might be a severe drawback in practical applications. In particular, this model class cannot capture any negative serial correlation. For the special case of binary data, we propose an extension of the NDARMA model class that allows for negative model parameters, and, hence, autocorrelations leading to the considerably larger and more flexible model class of generalized binary ARMA (gbARMA) processes. We provide stationary conditions, give the stationary solution, and derive stochastic properties of gbARMA processes. For the purely autoregressive case, classical Yule–Walker equations hold that facilitate parameter estimation of gbAR models. Yule–Walker type equations are also derived for gbARMA processes.
Effect of Temperature, Pressure, Feed Particle Size, and Feed Particle Density on Structural Characteristics and Reactivity of Chars Generated during Gasification of Pittsburgh No.8 Coal in a High-Pressure, High-Temperature Flow Reactor
Authors: Krishnamoorthy Vijayaragavan , Pisupati Sarma V.
Published: December 2019

The gasification behavior of coal under high-temperature and high-pressure conditions is important from the perspective of designing and optimizing high efficiency gasifiers and troubleshooting existing gasifiers. The effect of feed particle size, density, temperature, and pressure on char porous structure, morphology, reflectance, and reactivity under conditions relevant to entrained-flow gasification was investigated. The chars were generated over a range of temperatures (1100, 1300, and 1400 °C at 11.3 bar for the −150 + 106 µm fraction), pressures (3.4, 6.2, 11.3, 15.5, and 21.7 bar at 1300 °C for the −150 + 106 µm fraction), for various size fractions (−106 + 75, −150 + 106, −212 + 150, −420 + 212 µm at 1300 °C and 11.3 bar), and density fractions (<1.3, 1.3–1.6, >1.6g/cc for the −106 + 75 µm at 1300 °C and 11.3 bar) of Pittsburgh No.8 bituminous coal using a high-pressure, high-temperature flow reactor (HPHTFR) in a equimolar mixture of CO2 and N2. Chars were characterized for conversion, morphology, thermal swelling ratio, and reactivity using ash tracer technique, oil immersion microscopy, tap density technique, and a thermogravimetric analyzer, respectively, and the results were statistically analyzed to determine for effects by feed particle density, feed particle size, temperature, and pressure. The results showed that the conversion was most affected by temperature, followed by feed particle size, pressure, and feed particle density. In the case of structural characteristics (i.e., thermal swelling ratio and group-I char concentration), feed particle density affected group-I concentration, while both feed particle size and feed particle density affected thermal swelling ratio. Variation in vitrinite content and fragmentation affected the thermal swelling ratio and group-I char concentration. In the case of intrinsic reactivity, particle density showed the largest effect, followed by temperature, particle size, and pressure. An increase in reflectance and temperature was found to inversely affect intrinsic reactivity.