bluuebunny/crossref_metadata_2025 huggingface dataset:
Enterococci as Dominant Xylose Utilizing Lactic Acid Bacteria in Eri Silkworm Midgut and the Potential Use of Enterococcus hirae as Probiotic for Eri Culture
Authors: Unban Kridsada , Klongklaew Augchararat , Kodchasee Pratthana , Pamueangmun Punnita , Shetty Kalidas , Khanongnuch Chartchai
Published: January 2022

A total of 51 pentose utilizing lactic acid bacteria (LAB) were isolated from acid-forming bacteria in the midgut of healthy mature Eri silkworm using de Man, Rogosa and Sharpe (MRS) agar containing 10 g/L xylose (MRS-xylose) as the carbon source supplemented with 0.04% (w/v) bromocresol purple. Further analysis of 16S rRNA gene sequences revealed the highest prevalence of up to 35 enterococci isolates, which included 20 isolates of Enterococcus mundtii, followed by Entercoccus faecalis (eight isolates), Weissella cibaria (four isolates), Enterococcus hirae (two isolates), Enterococcus lactis (one isolate), and Enterococcus faecium (one isolate). All 51 LAB isolates showed positive growth on MRS containing a range of polysaccharides as the sole carbon source. All isolates were able to grow and form clear zones on MRS supplemented with 1 g/L xylose, while E. faecalis SC1, E. faecalis SCT2, and E. hirae SX2 showed tannin tolerance ability up to 5 g/L. Moreover, five isolates showed antimicrobial activity against Eri silkworm pathogens, including Bacillus cereus, Staphylococcus aureus, and Proteus vulgaris, with E. hirae SX2 having the highest inhibitory effect. Supplementation of live E. hirae SX2 on castor leaves significantly improved the weight and reduced the silkworm mortality when compared with the control group (p < 0.05). This cocci LAB can be considered as the new probiotic for Eri culture. Additionally, this finding presented the perspective of non-mulberry silkworm that could also be used as the model for further applying to new trends of the sericulture industry.
3D Echo Characterization of Proportionate and Disproportionate Functional Mitral Regurgitation before and after Percutaneous Mitral Valve Repair
Authors: Cimino Sara , Agati Luciano , Filomena Domenico , Maestrini Viviana , Monosilio Sara , Birtolo Lucia Ilaria , Mocci Michele , Mancone Massimo , Sardella Gennaro , Grayburn Paul , Fedele Francesco
Published: January 2022

Background: The impact of percutaneous mitral valve repair (PMVr) on long-term prognosis in patients with functional mitral regurgitation (FMR) is still unclear. Recently, a new conceptual framework classifying FMR as proportionate (P-MR) and disproportionate (D-MR) was proposed, according to the effective regurgitant orifice area/left ventricular end-diastolic volume (EROA/LVEDV) ratio. The aim was to assess its possible influence on PMVr efficacy. Methods: A total of 56 patients were enrolled. MV annulus, LV volumes and function were assessed. Global longitudinal strain (GLS) was also calculated. Patients were divided into two groups, according to the EROA/LVEDV ratio. Echocardiographic follow-up was performed after 6 months, and adverse events were collected after 12 months. Results: D-MR patients (n = 28, 50%) had a significantly more elliptical MV annulus (p = 0.048), lower tenting volume (p = 0.01), higher LV ejection fraction (LVEF: 32 ± 7 vs. 26 ± 5%, p = 0.003), lower LVEDV, LV end-systolic volume (LVESV) and mass (LVEDV/i: 80 ± 20 vs. 126 ± 27 mL, p = 0.001; LVESV/i: 60 ± 20 vs. 94 ± 23 mL, p < 0.001; LV mass: 249 ± 63 vs. 301 ± 69 gr, p = 0.035). GLS was more impaired in P-MR (p = 0.048). After 6 months, P-MR patients showed a higher rate of MR recurrence. After 12 months, the rate of CV death and rehospitalization due to HF was significantly higher in P-MR patients (46% vs. 7%, p < 0.001). P-MR status was strongly associated with CV death/rehospitalization (HR = 3.4, CI 95% = 1.3–8.6, p = 0.009). Conclusions: Patients with P-MR seem to have worse outcomes after PVMr than D-MR patients. Our study confirms the importance of the EROA/LVEDV ratio in defining different subsets of FMR based on the anatomical characteristic of MV and LV.
Opioid Consumption in Chronic Pain Patients: Role of Perceived Injustice and Other Psychological and Socioeconomic Factors
Authors: Kleinmann Barbara , Wolter Tilman
Published: January 2022

Background: Chronic pain is a complex biopsychosocial phenomenon. Lifestyle, behavioral, socioeconomic, and psychosocial factors such as depression and perceived injustice are often associated with the development of chronic pain and vice versa. We sought to examine the interaction of these factors with opioid intake. Methods: At our institution, 164 patients with chronic pain undergoing an interdisciplinary assessment within a three-month period participated in the study and completed the Injustice Experience Questionnaire (IEQ). Data regarding opioid intake, pain levels, pain diagnosis, depression, anxiety, stress, quality of life, pain-related disability, habitual well-being, occupational status, and ongoing workers compensation litigation were extracted from the patients’ charts. Results: Approximately one-fourth of the patients used opioids. The IEQ total was significantly higher in patients using Schedule III opioids. Depression, but not the anxiety and stress scores, were significantly higher in patients using opioids. There were no significant differences regarding pain-related disability, habitual well-being, and the coded psychosocial diagnoses. In the patient group without opioids, the percentage of employed persons was significantly higher but there were no significant differences regarding work leave, pension application, or professional education. Conclusions: Opioid use appears to be more closely related to psychological factors and single social determinants of pain than to somatic factors.
Laboratory Profile of COVID-19 Patients with Hepatitis C-Related Liver Cirrhosis
Authors: Cerbu Bianca , Grigoras Mirela Loredana , Bratosin Felix , Bogdan Iulia , Citu Cosmin , Bota Adrian Vasile , Timircan Madalina , Bratu Melania Lavinia , Levai Mihaela Codrina , Marincu Iosif
Published: January 2022

Patients with cirrhosis are known to have multiple comorbidities and impaired organ system functioning due to alterations caused by chronic liver failure. In the past two years, since the COVID-19 pandemic started, several studies have described the affinity of SARS-CoV-2 with the liver and biliary cells. Considering hepatitis C as a significant independent factor for cirrhosis in Romania, this research was built on the premises that this certain group of patients is susceptible to alterations of their serum parameters that are yet to be described, which might be useful in the management of COVID-19 in these individuals. A retrospective cohort study was developed at a tertiary hospital for infectious disease in Romania, which included a total of 242 patients with hepatitis C cirrhosis across two years, out of which 46 patients were infected with SARS-CoV-2. Stratification by patient weight and COVID-19 status identified several important laboratory serum tests as predictors for acute-on-chronic liver failure and risk for intensive care unit admission. Thus, white blood cell count, lymphocyte count, ferritin, hypoglycemia, prothrombin time, and HCV viral load were independent risk factors for ACLF in patients with COVID-19. High PT, creatinine, BUN, and HCV viral load were the strongest predictors for ICU admission. Inflammatory markers and parameters of gas exchange were also observed as risk factors for ACLF and ICU admission, including procalcitonin, CRP, IL-6, and D-dimers. Our study questions and confirms the health impact of COVID-19 on patients with cirrhosis and whether their laboratory profile significantly changes due to SARS-CoV-2 infection.
The Influence of Parathyroidectomy on Osteoporotic Fractures in Kidney Transplant Recipients: Results from a Retrospective Single-Center Trial
Authors: Jehn Ulrich , Kortenhorn Anja , Schütte-Nütgen Katharina , Thölking Gerold , Westphal Florian , Strauss Markus , Wennmann Dirk-Oliver , Pavenstädt Hermann , Suwelack Barbara , Görlich Dennis , Reuter Stefan
Published: January 2022

Kidney transplant (KTx) recipients are a high-risk population for osteoporotic fractures. We herein aim to identify the role of pre-transplant parathyroidectomy (PTX) and other modifiable factors associated with osteoporotic fractures in KTx recipients. We conducted a retrospective study involving 711 adult patients (4608 patient-years) who were transplanted at our center between January 2007 and June 2015. Clinical data were extracted from patients’ electronic medical records. Different laboratory and clinical parameters for mineral bone disease (MBD) and osteoporosis, including medication, were evaluated. We chose fracture events unrelated to malignancies or adequate trauma as the primary endpoint. Osteoporotic fractures occurred in 47 (6.6%) patients (median 36.7 months, IQR 45.9) after KTx (fracture incidence of 10 per 1000 person-years). Prior to KTx, subtotal PTX was performed in 116 patients (16.3%, median time 4.2 years before KTx, IQR 5.0). Of the patients with fracture (n = 47), only one (2.2%) patient had previously undergone PTX. After adjusting for the known fracture risk factors MBD and osteoporosis, PTX remained a protective factor against fractures (HR 0.134, CI 0.018–0.991, p = 0.049). We observed a reduced risk for pathological fractures in KTx patients who underwent PTX, independent from elevated parathyroid hormone at the time of KTx or afterwards.
The Significance of the Alter miR let-7a and miR-335 Expression Level Regulating the CCR7/CCL19 Axis as Potential Biomarkers of Tumor Progression in NSCLC
Authors: Baran Kamila , Kordiak Jacek , Jabłoński Sławomir , Antczak Adam , Brzeziańska-Lasota Ewa
Published: January 2022

The chemokine receptor 7/C-C ligand 19 chemokine (CCR7/CCL19) has been implicated in the development and progression of NSCLC. Its expression is regulated by various epigenetic factors including miRNAs. The aim of this study was to assess the expression of CCR7/CCL19 in cancer tissue in relation to that of miRNAs (miR-let-7a, miR-335) as transcriptional regulators. The expression of the tested miRNAs was also evaluated in serum exosomes. Sixty patients (n = 60) were enrolled in the study. The total expression of the studied mRNA and miRNAs were evaluated using qPCR. Tumor tissue fragments, macroscopically unchanged adjacent tissue, and serum were used as controls. Higher CCR7 and CCL19 mRNA expression levels were observed in tumor tissue compared to control. According to stages of the disease (AJCC tumor staging), the greatest expression level of the studied genes’ mRNA was observed in patients with stage III. In NSCLC patients, lower miR let-7a expression level was observed in tumor tissue compared to serum; however, miR-335 expression level was higher (p < 0.05). The expression level of miR-335 positively correlated with tumor size (T features according to pTNM staging) and AJCC tumor staging, while miR let-7a had a negative correlation (p > 0.05) with liquid biopsy. Significantly greater miR-335 expression level and lower miR let-7a expression level in serum were observed in patients with metastases to lymph nodes. Our findings reveal a significant correlation between the expression levels of the mRNA of the studied genes and miRNAs. Changes in miR-335 and miR let-7a expression levels in the serum exosomes of NSCLC patients in relation to lymph node metastases and tumor stage may serve as a non-invasive molecular biomarker of tumor progression.
Subclinical Atherosclerosis Measure by Carotid Ultrasound and Inflammatory Activity in Patients with Rheumatoid Arthritis and Spondylarthritis
Authors: Rojas-Giménez Marta , López-Medina Clementina , Ladehesa-Pineda María Lourdes , Puche-Larrubia María Ángeles , Gómez-García Ignacio , Calvo-Gutiérrez Jerusalem , Seguí-Azpilcueta Pedro , Ábalos-Aguilera María del Carmen , Ruíz-Vilchez Desirée , Escudero-Contreras Alejandro , Collantes-Estévez Eduardo
Published: January 2022

Objective: To compare the effect of inflammation on subclinical atherosclerosis using carotid ultrasound in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA). Methods: Cross-sectional study including 347 participants (148 RA, 159 SpA, and 40 controls). We measured the carotid intima media thickness (cIMT) and detection of atheromatous plaques using carotid ultrasound. We recorded disease activity (DAS28-CRP/ASDAS-CRP) and traditional cardiovascular risk factors. We performed descriptive, bivariate, and linear multivariate analyses (dependent variable: cIMT) to evaluate the influence of diagnosis on cIMT in all patients. Two additional multivariate analyses were performed by stratifying patients according to their inflammatory activity. Results: cIMT correlated with the mean CRP during the previous 5 years in RA, but not with CRP at the cut-off date. We did not find such differences in patients with SpA. The first multivariate model revealed that increased cIMT was more common in patients with RA than in those with SpA (β coefficient, 0.045; 95% confidence interval (95% CI), 0.0002–0.09; p = 0.048) after adjusting for age, sex, disease course, and differential cardiovascular risk factors (arterial hypertension, smoking, statins, and corticosteroids). The second model revealed no differences in cIMT between the 2 groups of patients classified as remission–low activity (β coefficient, 0.020; 95% CI, −0.03 to 0.080; p = 0.500). However, when only patients with moderate–high disease activity were analysed, the cIMT was 0.112 mm greater in those with RA (95% CI, 0.013–0.212; p = 0.026) than in those with SpA after adjusting for the same variables. Conclusions: Subclinical atherosclerosis measured by carotid ultrasound in patients with RA and SpA is comparable when the disease is well controlled. However, when patients have moderate–high disease activity, cIMT is greater in patients with RA than in those with SpA after adjusting for age, sex, disease course, and cardiovascular risk factors. Our results point to greater involvement of disease activity in subclinical atherosclerosis in patients with RA than in those with SpA.
Taurine and Its Derivatives: Analysis of the Inhibitory Effect on Platelet Function and Their Antithrombotic Potential
Authors: Roşca Adrian Eugen , Vlădăreanu Ana-Maria , Mirica Radu , Anghel-Timaru Cristina-Mihaela , Mititelu Alina , Popescu Bogdan Ovidiu , Căruntu Constantin , Voiculescu Suzana Elena , Gologan Şerban , Onisâi Minodora , Iordan Iuliana , Zăgrean Leon
Published: January 2022

Taurine is a semi-essential, the most abundant free amino acid in the human body, with a six times higher concentration in platelets than any other amino acid. It is highly beneficial for the organism, has many therapeutic actions, and is currently approved for heart failure treatment in Japan. Taurine has been repeatedly reported to elicit an inhibitory action on platelet activation and aggregation, sustained by in vivo, ex vivo, and in vitro animal and human studies. Taurine showed effectiveness in several pathologies involving thrombotic diathesis, such as diabetes, traumatic brain injury, acute ischemic stroke, and others. As human prospective studies on thrombosis outcome are very difficult to carry out, there is an obvious need to validate existing findings, and bring new compelling data about the mechanisms underlying taurine and derivatives antiplatelet action and their antithrombotic potential. Chloramine derivatives of taurine proved a higher stability and pronounced selectivity for platelet receptors, raising the assumption that they could represent future potential antithrombotic agents. Considering that taurine and its analogues display permissible side effects, along with the need of finding new, alternative antithrombotic drugs with minimal side effects and long-term action, the potential clinical relevance of this fascinating nutrient and its derivatives requires further consideration.
Efficacy and Toxicity of Classical Immunosuppressants, Retinoids and Biologics in Hidradenitis Suppurativa
Authors: Das Kinnor , Daveluy Steven , Kroumpouzos George , Agarwal Komal , Podder Indrashis , Farnbach Katherine , Ortega-Loayza Alex G. , Szepietowski Jacek C. , Grabbe Stephan , Goldust Mohamad
Published: January 2022

Hidradenitis suppurativa (HS) is a chronic inflammatory disorder of the apocrine glands characterized by recurrent episodes. Although several therapies exist, none is completely curative. Several immunosuppressives have been studied with encouraging results and targeted approaches. In this review, we highlight the various immunosuppressives used in this condition along with their salient features to enable physicians to choose the correct therapy for their patients. The search of the peer-reviewed literature included clinical trials, scientific reviews, case series, case reports, and guidelines. The literature was identified from electronic databases (MEDLINE and PubMed) through November 2021; additional articles were included from the references of the identified articles.
Preliminary Results on Heparin-Modified Double-Layered PCL and PLA-Based Scaffolds for Tissue Engineering of Small Blood Vessels
Authors: Domalik-Pyzik Patrycja , Morawska-Chochół Anna
Published: January 2022

Low-diameter blood vessels are challenging to replace with more traditional synthetic vascular grafts. Therefore, the obvious choice is to try to regenerate small veins and arteries through tissue-engineering approaches. However, the layered structure of native vessels and blood compatibility issues make this a very challenging task. The aim of this study is to create double-layered tubular scaffolds with enhanced anticoagulant properties for the tissue engineering of small blood vessels. The scaffolds were made of a polycaprolactone-based porous outer layer and a polylactide-based electrospun inner layer modified with heparin. The combination of thermally induced phase separation and electrospinning resulted in asymmetric scaffolds with improved mechanical properties. The release assay confirmed that heparin is released from the scaffolds. Additionally, anticoagulant activity was shown through APTT (activated partial thromboplastin time) assay. Interestingly, the endothelial cell culture test revealed that after 14 days of culture, HAECs (human aortic endothelial cell lines) tended to organize in chain-like structures, typical for early stages of vascular formation. In the longer culture, HAEC viability was higher for the heparin-modified scaffolds. The proposed scaffold design and composition have great potential for application in tissue engineering of small blood vessels.
Pneumocystis Pneumonia: Pitfalls and Hindrances to Establishing a Reliable Animal Model
Authors: Chesnay Adélaïde , Paget Christophe , Heuzé-Vourc’h Nathalie , Baranek Thomas , Desoubeaux Guillaume
Published: January 2022

Pneumocystis pneumonia is a severe lung infection that occurs primarily in largely immunocompromised patients. Few treatment options exist, and the mortality rate remains substantial. To develop new strategies in the fields of diagnosis and treatment, it appears to be critical to improve the scientific knowledge about the biology of the Pneumocystis agent and the course of the disease. In the absence of in vitro continuous culture system, in vivo animal studies represent a crucial cornerstone for addressing Pneumocystis pneumonia in laboratories. Here, we provide an overview of the animal models of Pneumocystis pneumonia that were reported in the literature over the last 60 years. Overall, this review highlights the great heterogeneity of the variables studied: the choice of the host species and its genetics, the different immunosuppressive regimens to render an animal susceptible, the experimental challenge, and the different validation methods of the model. With this work, the investigator will have the keys to choose pivotal experimental parameters and major technical features that are assumed to likely influence the results according to the question asked. As an example, we propose an animal model to explore the immune response during Pneumocystis pneumonia.
Design and Development of an Intelligent Clinical Decision Support System Applied to the Evaluation of Breast Cancer Risk
Authors: Casal-Guisande Manuel , Comesaña-Campos Alberto , Dutra Inês , Cerqueiro-Pequeño Jorge , Bouza-Rodríguez José-Benito
Published: January 2022

Breast cancer is currently one of the main causes of death and tumoral diseases in women. Even if early diagnosis processes have evolved in the last years thanks to the popularization of mammogram tests, nowadays, it is still a challenge to have available reliable diagnosis systems that are exempt of variability in their interpretation. To this end, in this work, the design and development of an intelligent clinical decision support system to be used in the preventive diagnosis of breast cancer is presented, aiming both to improve the accuracy in the evaluation and to reduce its uncertainty. Through the integration of expert systems (based on Mamdani-type fuzzy-logic inference engines) deployed in cascade, exploratory factorial analysis, data augmentation approaches, and classification algorithms such as k-neighbors and bagged trees, the system is able to learn and to interpret the patient’s medical-healthcare data, generating an alert level associated to the danger she has of suffering from cancer. For the system’s initial performance tests, a software implementation of it has been built that was used in the diagnosis of a series of patients contained into a 130-cases database provided by the School of Medicine and Public Health of the University of Wisconsin-Madison, which has been also used to create the knowledge base. The obtained results, characterized as areas under the ROC curves of 0.95–0.97 and high success rates, highlight the huge diagnosis and preventive potential of the developed system, and they allow forecasting, even when a detailed and contrasted validation is still pending, its relevance and applicability within the clinical field.
From Fragility to Resilience—How Prepared Was the Romanian Business Environment to Face the COVID-19 Crisis?
Authors: Demyen Suzana
Published: January 2022

The issue of business resilience is a topical one, in the context of which a large number of the companies on the market have faced many challenges in the last two years, raising the issue of market survival. But was the Romanian business environment ready to face the COVID-19 crisis? How prepared is it to continue to face the obstacles posed by the pandemic? The purpose of this paper is to identify the main effects that the pandemic has generated on Romanian SMEs, while presenting the results of a study on this topic. We proceeded to determine the level of familiarity of respondents on the evolution of SMEs during the pandemic and the study of their level of interest, on the effects generated by the current epidemiological context, and on the evolution of the business environment, while analysing the level of optimism/pessimism of the respondents, regarding the general evolution of the Romanian business environment. Although some companies are open to implementing change, there is also a significant percentage of firms that, for various reasons, do not consider making major changes in the near future, either because they are not aware of the need for change or out of fear.
Seamless Handover Scheme for MEC/SDN-Based Vehicular Networks
Authors: Monir Nirmin , Toraya Maha M. , Vladyko Andrei , Muthanna Ammar , Torad Mohamed A. , El-Samie Fathi E. Abd , Ateya Abdelhamied A.
Published: January 2022

With the recent advances in the fifth-generation cellular system (5G), enabling vehicular communications has become a demand. The vehicular ad hoc network (VANET) is a promising paradigm that enables the communication and interaction between vehicles and other surrounding devices, e.g., vehicle-to-vehicle (V2V) and vehicle-to-everything (V2X) communications. However, enabling such networks faces many challenges due to the mobility of vehicles. One of these challenges is the design of handover schemes that manage the communications at the intersection of coverage regions. To this end, this work considers developing a novel seamless and efficient handover scheme for V2X-based networks. The developed scheme manages the handover process while vehicles move between two neighboring roadside units (RSU). The developed mechanism is introduced for multilane bidirectional roads. The developed scheme is implemented by multiple-access edge computing (MEC) units connected to the RSUs to improve the implementation time and make the handover process faster. The considered MEC platform deploys an MEC controller that implements a control scheme of the software-defined networking (SDN) controller that manages the network. The SDN paradigm is introduced to make the handover process seamless; however, implementing such a controlling scheme by the introduction of an MEC controller achieves the process faster than going through the core network. The developed handover scheme was evaluated over the reliable platform of NS-3, and the results validated the developed scheme. The results obtained are presented and discussed.
Accessing Citizens’ Perceptions of Land-Related Policy in a Social Media Setting: The Case of Rural Grazing Area Settlement Programme in Nigeria
Authors: Adekola Oluwafemi , Krigsholm Pauliina , Riekkinen Kirsikka
Published: January 2022

Social media have opened interesting avenues for accessing active citizenry’s perceptions, providing an important tool for the promotion of the successful implementation of policy. Although social media data have been used to access citizens’ perceptions in various fields of study, they have yet to be adequately examined in the area of land-related policies. This study showcases the potential of the use of social media data to access citizens’ perceptions of land-related policies in the context of a developing country. We systematically selected YouTube videos with expressions of citizens’ perceptions of the Rural Grazing Area settlement programme in Nigeria. The findings from the social media data indicate that whilst some people perceived the policy’s potential benefits, most expressed dissatisfaction with it, and some suggested alternative policy approaches. The results suggest that social media data may be a promising avenue for accessing citizens’ opinions even in the case of land-related policies. Social media data must be accessed and used with caution, however, taking into consideration their limitations. This study’s main contribution lies in the demonstration that social media data can provide valuable insights into citizens’ perceptions of sensitive interventions, including land-related policies.
Compensation in Time and Space: Prominence Marking in Aging and Disease
Authors: Thies Tabea , Hermes Anne , Mücke Doris
Published: January 2022

This study aims to explore the effects of healthy aging and Parkinson’s disease on speech motor performance. One area of speech production which requires fine speech motor control is prominence marking. Therefore, strategies of prominence marking of three speaker groups with four speakers each were investigated: younger speakers, older speakers, and speakers with Parkinson’s disease (PD). Acoustic and articulatory data were collected. Speech data were analyzed focusing on prominence-related adjustments of vowel production and tongue body movements in the temporal and spatial domain. Longer durations, varying initiation of the tongue movements and smaller vowel sizes in older speakers and in speakers with PD were found compared to younger speakers. The data indicate further that all speaker groups mark prominence by changing relevant parameters in the vowel articulation; however, strategies seem to differ between the groups: (i) in the temporal domain, articulatory movement durations increase with age and are further prolonged in speakers with PD; (ii) in the spatial domain, the articulation space is resized by the older speakers in a non-symmetrical way, while no systematic vocalic modulations were found for speakers with PD. To conclude, the speech system seems to be affected by age and disease, but speakers develop compensatory strategies to counteract influences in the spatial domain.
Photobiomodulation Therapy Combined with Static Magnetic Field (PBMT–SMF) on Spatiotemporal and Kinematics Gait Parameters in Post-Stroke: A Pilot Study
Authors: Dumont Arislander Jonathan Lopes , Casalechi Heliodora Leão , Tomazoni Shaiane Silva , Grecco Luanda Collange , Galli Manuela , Oliveira Claudia Santos , Leal-Junior Ernesto Cesar Pinto
Published: January 2022

Background: Gait deficit is a major complaint in patients after stroke, restricting certain activities of daily living. Photobiomodulation therapy combined with a static magnetic field (PBMT-SMF) has been studied for several diseases, and the two therapies are beneficia. However, their combination has not yet been evaluated in stroke. Therefore, for PBMT–SMF to be used more often and become an adjunctive tool in the rehabilitation of stroke survivors at physical therapy rehabilitation centers and clinics, some important aspects need to be clarified. Purpose: This study aimed to test different doses of PBMT–SMF, to identify the ideal dose to cause immediate effects on the spatiotemporal and kinematic variables of gait in post-stroke patients. Methods: A randomized, triple-blinded, placebo-controlled crossover pilot study was performed. A total of 10 individuals with hemiparesis within 6 months to 5 years since the occurrence of stroke, aged 45–60 years, were included in the study. Participants were randomly assigned and treated with a single PBMT–SMF dose (sham, 10 J, 30 J, or 50 J) on a single application, with one dose per stage at 7-day intervals between stages. PBMT–SMF was applied with a cluster of 12 diodes (4 of 905 nm laser, 4 of 875 nm LEDs, and 4 of 640 nm LEDs, SMF of 35 mT) at 17 sites on both lower limbs after baseline evaluation: plantar flexors (2), knee extensors (9), and flexors (6). The primary outcome was self-selected walking speed, and the secondary outcomes were kinematic parameters. Gait analysis was performed using SMART-D 140® and SMART-D INTEGRATED WORKSTATION®. The outcomes were measured at the end of each stage after the single application of each PBMT–SMF dose tested. Results: No significant differences (p > 0.05) in spatiotemporal variables were observed between the different doses, compared with the baseline evaluation. However, differences (p < 0.05) were observed in the kinematic variable of the hip in the paretic and non-paretic limbs, specifically in the minimum flexion/extension angulation during the support phase (HMST–MIN) in doses 10 J, 30 J, and 50 J. Conclusions: A single application of PBMT–SMF at doses of 10 J, 30 J, and 50 J per site of the lower limbs did not demonstrate positive effects on the spatiotemporal variables, but it promoted immediate effects in the kinematic variables of the hip (maximum and minimum flexion/extension angulation during the support phase) in the paretic and non-paretic limbs in post-stroke people.
Anatomy, Biomechanics, and Loads of the Wrist Joint
Authors: Eschweiler Jörg , Li Jianzhang , Quack Valentin , Rath Björn , Baroncini Alice , Hildebrand Frank , Migliorini Filippo
Published: January 2022

The wrist is by far the most differentiated section of the musculoskeletal system. The spectrum of wrist injuries ranges from minor injuries to complex traumas with simultaneous loss of functions, resulting in enormous economic costs. A proper understanding of the anatomy and biomechanics is essential for effective treatment, whether conservative or surgical; this applies to the wrist no less than to other parts of the human body. Here; information on the wrist anatomy; kinematics; and biomechanical behavior is presented, commencing with a brief explanation of the structure of its hard and soft tissues. Eight carpal bones in combination with two forearm bones (radius and ulna) construct the wrist joint. The motion of the wrist joint is initiated by the muscles of the forearm, and strong and short ligaments ensure the stability of the wrist. All of these components are essential to bringing functions to the wrist joint because these structures allow wrist mobility and sustainability. In addition, the kinematics of the wrist joint is presented and different biomechanical model approaches. The therapeutic (surgical) restoration of the balance between the load–bearing capacity and the actual stress on a joint is the prerequisite for a lifelong and trouble-free function of a joint. Regarding the complex clinical problems, however, a valid biomechanical wrist joint model would be necessary as assistance, to improve the success of systematized therapies based on computer–aided model–based planning and intervention.
The Value of Literature, Today and Tomorrow
Authors: Bump Jerome F. A.
Published: January 2022

While reports of the death of literature are greatly exaggerated, reports of the decline of Aestheticism, New Criticism, and the printed word are not. Literature as a critique of society is alive today, but to survive tomorrow in any form it will need to engage environmental, climate, and pandemic public health issues. Without such engagement, there will be no civilization, and, thus, no literature. Literature can survive now, but to thrive, essays in literary criticism may have to not only (i) continue to discuss canonical and (ii) minority writing but also (iii) partner with cultural studies and/or (iv) expand the definition of literature to include “the best stories”, (v) especially multimedia stories. Critics would also be well advised to (vi) balance abstraction and theory with close, detailed readings of literature. Editors might encourage new essays demonstrating that (vii) unity in literature is compatible with the celebration of diversity, that explore (viii) the relationship of literature and science in general, and (ix) the integration of unity in literature with the search for unified theory in science. Finally, editors might encourage new essays on less trendy topics such as (x) literature focused on feelings and/or (xi) how literature helps individual readers make radical changes in their lives.
Cellulose for the Production of Air-Filtering Systems: A Critical Review
Authors: Lippi Martina , Riva Laura , Caruso Manfredi , Punta Carlo
Published: January 2022

The control of airborne contaminants is of great interest in improving air quality, which has deteriorated more and more in recent years due to strong industrial growth. In the last decades, cellulose has been largely proposed as suitable feedstock to build up eco-friendly materials for a wide range of applications. Herein, the issue regarding the use of cellulose to develop air-filtering systems is addressed. The review covers different cellulose-based solutions, ranging from aerogels and foams to membranes and films, and to composites, considering either particulate filtration (PM10, PM2.5, and PM0.3) or gas and water permeation. The proposed solutions were evaluated on the bases of their quality factor (QF), whose high value (at least of 0.01 Pa−1 referred to commercial HEPA (high-efficiency particulate air) filters) guarantees the best compromise between high filtration efficiency (>99%) and low pressure drop (<1 kPa/g). To face this aspect, we first analyzed the different morphological aspects which can improve the final filtration performance, outlining the importance on using nanofibers not only to increase surface area and to modulate porosity in final solutions, but also as reinforcement of filters made of different materials. Besides the description of technological approaches to improve the mechanical filtration, selected examples show the importance of the chemical interaction, promoted by the introduction of active functional groups on cellulose (nano)fibers backbone, to improve filtration efficiency without reducing filter porosity.
Setting Up and Assessing a New Micro-Structured Waveguiding Fluorescent Architecture on Glass Entirely Elaborated by Sol–Gel Processing
Authors: Bonnel Morgane , Marzouk Ibtihel , Riassetto David , Morand Alain , Bucci Davide , Langlet Michel
Published: January 2022

Channel waveguides with diffraction gratings at their input and output for light injection and extraction, respectively, are extensively exploited for optical and photonic applications. In this paper, we report for the first time on such an architecture on glass entirely elaborated by sol–gel processing using a titanium-oxide-based photoresist that can be imprinted through a single photolithography step. This work is more particularly focused on a fluorescent architecture including channel waveguides doped with a ruthenium-complex fluorophore (tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II), Rudpp). The study demonstrates that this original sol–gel micro-structured architecture is well adapted to efficient channel waveguide/diffraction grating coupling and propagation of the fluorescence excitation and emission signals in the core of the channel waveguide. It demonstrates, in particular, a relatively large tolerance of several degrees in the angular injection fiber positioning and an important axial and vertical fiber spatial positioning tolerance of more than 100 µm at the Rudpp emission wavelength. The measurements also indicate that, in the conditions tested in this work, a Rudpp concentration of around 0.1 mM and a channel waveguide length of 2 to 5 mm offer the best trade-off in terms of excitation signal propagation and emission signal detection. This work constitutes a promising preliminary step toward the integration of our architecture into a microfluidic platform for fluorescence measurement in a liquid medium and waveguiding configuration.
TEOS Nanocomposites for the Consolidation of Carbonate Stone: The Effect of Nano-HAp and Nano-SiO2 Modifiers
Authors: Rodrigues Alexandra , Sena da Fonseca Bruno , Ferreira Pinto Ana Paula , Piçarra Susana , Montemor Maria de Fátima
Published: January 2022

This study aimed at evaluating the effect of hydroxyapatite (HAp) nanosized structures and nanoparticles of hydrophilic silica as modifiers of both acid- and alkaline-catalysed tetraethoxysilane (TEOS)-based products for the consolidation of carbonate stones. Their initial effectiveness and some compatibility aspects were assessed in a porous limestone (sound and artificially aged Ançã stone samples) and two types of treatment (capillary absorption and brushing). The studied products were examined by scanning electron microscopy (SEM) and micro-Raman spectroscopy. Their depth of penetration and strengthening effect were evaluated through drilling resistance. Their action on the substrate was also further assessed by non-destructive methods based on colour variation and Shore-D hardness. Treated stone samples were dissimilarly affected by the tested treatments and exhibited a significant increase in strength with a low risk of over-strengthening. Adequate in-depth penetration patterns, as well as colour compatibility with the substrate were obtained with some of the prepared formulations through two types of treatment, both in sound and aged stone samples. The potential most effective treatments with the lowest colour change were obtained with the acid-catalysed TEOS-based products modified with HAp nanosized structures.
Impact of Surfactant and Calcium Sulfate Type on Air-Entraining Effectiveness in Concrete
Authors: Sypek Maciej , Latawiec Rafał , Łaźniewska-Piekarczyk Beata , Pichór Waldemar
Published: January 2022

The paper presents the evaluation of the influence of calcium sulfate on the air void microstructure in concrete and its action mechanism depending on the character of the air-entraining agent. Gypsum dehydration has been previously proven to negatively influence the air void structure of air-entrained concrete. Ettringite, nucleating from tricalcium aluminate and calcium sulfate, influences the adsorption and mode of action of anionic-based polycarboxylate ether admixtures. The authors suspected the admixture’s air-entraining mechanism was also affected by these characteristics. Gypsum dehydration was confirmed to influence the air void structure. In the case of the anionic surfactant, the content of air bubbles smaller than 300 µm was lower compared to cement with gypsum and hemihydrate. On the other hand, the content of air voids with a diameter up to 60 µm, which are the most favorable, was higher. The results obtained led to the conclusion that the mechanism of air entrainment was twofold, and in most cases occurred through the lowering of surface tension and/or through the adsorption of surfactant on cement grains. The adsorptive mechanism was proved to be more effective in terms of the total air content and the structure of the air void system. The results and conclusions of the study provide guidelines to determine the proper surfactant type to reduce the risk of improper air entrainment of concrete, and emphasize the importance of gypsum dehydration of cement in the process of air entrainment.
Power-Dependent Investigation of Photo-Response from GeSn-Based p-i-n Photodetector Operating at High Power Density
Authors: Chang Chiao , Cheng Hung-Hsiang , Sevison Gary A. , Hendrickson Joshua R. , Li Zairui , Agha Imad , Mathews Jay , Soref Richard A. , Sun Greg
Published: January 2022

We report an investigation on the photo-response from a GeSn-based photodetector using a tunable laser with a range of incident light power. An exponential increase in photocurrent and an exponential decay of responsivity with increase in incident optical power intensity were observed at higher optical power range. Time-resolved measurement provided evidence that indicated monomolecular and bimolecular recombination mechanisms for the photo-generated carriers for different incident optical power intensities. This investigation establishes the appropriate range of optical power intensity for GeSn-based photodetector operation.
Improving the Conductivity of the PEDOT:PSS Layers in Photovoltaic Cells Based on Organometallic Halide Perovskites
Authors: Spivak Yuliya , Muratova Ekaterina , Moshnikov Vyacheslav , Tuchkovsky Alexander , Vrublevsky Igor , Lushpa Nikita
Published: January 2022

Among conductive polymers, PEDOT films find the widest application in electronics. For photovoltaic applications, studies of their optical properties, stability, and electrical conductivity are of greatest interest. However, the PEDOT:PSS transport layers, when used in photovoltaic cells, have a high electrical resistance, which prevents solar cells from increasing their efficiency. One of the promising ways to improve their electrical properties is the use of composite materials based on them, in which the conductivity can be increased by introducing various additives. In this work, conductive polymer films PEDOT:PSS (poly (3,4-ethylenedioxythiophene):polystyrene sulfonate acid) doped with a number of amines (Pentylamine, Octylamine, Diethylamine, Aniline with carbon nanotubes) were obtained and studied. It is shown that, depending on the concentration of dopants, the electrical conductivity of PEDOT:PSS films can be significantly improved. In this case, the light transmission of the films practically does not change. The process of improving the conductivity by treating the surface of the finished film with amines, followed by heat treatment, was studied. It is assumed that the improvement in conductivity is the result of the self-assembly of monolayers of organic molecules on the surface of the PEDOT:PSS film leading to its p-doping due to intermolecular interaction.
Creation of 3D Model of Stainless-Steel Billet’s Grain after Three-High Screw Rolling
Authors: Skripalenko Mikhail Mikhailovich , Rogachev Stanislav Olegovich , Romantsev Boris Alekseevich , Galkin Sergei Pavlovich , Kaputkina Liudmila Mikhailovna , Skripalenko Mikhail Nikolaevich , Danilin Andrei Vladimirovich , Fadeev Viktor Aleksandrovich
Published: January 2022

The three-high screw rolling of AISI 321 billet from 60 mm to 52 mm diameter was performed using an MISIS-100T mill. When screw rolling was carried out, a set of sections were made in the billet’s cross-section at the stationary stage of screw rolling. SolidWorks was applied to make the 3D model of the rolled billet’s grain using microstructure images. The same technique was applied for the creation of the 3D model of a nondeformed billet’s grain. A comparison of the 3D models’ shape and dimensions before and after screw rolling was made. It was established that, compared to the nondeformed grain model, the screw rolled billet’s grain model was twisted and elongated along some angle in the rolling direction. This angle’s value is commensurable to the roll’s feed angle during the experimental rolling. Anisotropy indexes of before and after rolling grain models were estimated and compared to the anisotropy indexes obtained via the sections’ analysis in earlier research. Difference did not exceed 5%.
The Influence of Abrasive and Acidic Aggressions on the Surface Condition of Flowable Composite Resin
Authors: Tărăboanță Ionuț , Stoleriu Simona , Gurlui Silviu , Nica Irina , Tărăboanță-Gamen Andra Claudia , Iovan Alexandru , Andrian Sorin
Published: January 2022

The aim of this in vitro study was to evaluate the effect of hydrochloric acid associated with the abrasive effect of toothbrushing on the surface condition of three flowable composite resins used for direct restoration. Seventy samples of each composite resin: Grandio Flow (VOCO, Germany)—group A, Filtek Ultimate Flow (3M-ESPE, MN, USA)—group B, G-aenial Flo X (GC Europe)—group C were prepared, submersed in hydrochloric acid 30% for 60 min and then submitted to simulated toothbrushing procedure using 5000 cycles with toothbrushes with medium and hard bristles, immediately after the chemical attack, after 30 min or without any chemical attack. The sample’s surface roughness was analyzed using a noncontact profilometer (Dektak XT, Bruker, USA). ANOVA and post hoc Bonferroni tests, with a p < 0.05, were used to analyze the values. Hydrochloric acid action for 60 min and six months of toothbrushing using toothbrushes having medium hardness or firm bristles affects the surface roughness of tested flowable composite resins. Toothbrushing with firm bristles immediately after acidic challenge determines increased surface roughness for two of the three flowable composite resins (Grandio Flow and Filtek Ultimate Flow). Toothbrushing with medium or firm bristles thirty minutes after the acidic aggression determine no effect on surface condition of flowable composite resins.
Long-Term Behavior of Cement Mortars Based on Municipal Solid Waste Slag and Natural Zeolite—A Comprehensive Physico-Mechanical, Structural and Chemical Assessment
Authors: Thomas Marta , Osińska Małgorzata , Ślosarczyk Agnieszka
Published: January 2022

Limitations in natural aggregate resources and the continuous increase in the demand for concrete as a building material, as well as the increase in the production of waste and the problem with its storage were the reasons for attempts to replace the sand fraction in cement matrices with a corresponding slag fraction. Municipal solid waste incineration (MSWI) slag, which is a product of waste incineration, can be used as an aggregate. This extends its service life and reduces landfill waste. Therefore, three types of cement mortars with different aggregate composition were prepared. In addition, to increase the durability of the cement matrix and the degree of immobilization of harmful heavy metals and salts present in the slag, a natural zeolite with pozzolanic properties was used. A set of tests was carried out on fresh mortar and hardened mortar, including strength tests after 7, 28 and 360 days. What is more, chemical tests were undertaken, including the content of chlorides and sulfates, leaching using the TCLP method and oxide composition. The conducted tests revealed that all mortars had similar strength properties and demonstrated the effectiveness of immobilizing harmful substances contained in the municipal solid waste incineration (MSWI) slag by cementing.