bluuebunny/crossref_metadata_2025 huggingface dataset:
Governance through Translation: Policies and Practices in Brunei Darussalam
Authors: Yusof Badriyah , Azalie Izni Azrein
Published: November 2024

The research investigated how translation functions as an object of governance in Brunei Darussalam, guided by the polysystem theory. Translation served as a critical component within the communication framework, affecting domains like education, economy, and information technology. Applying qualitative-descriptive methods, including experiential insights and observational data, the research explored how translation activities were regulated and integrated across government institutions to promote social cohesion, accessibility, and national development. In Brunei, translation was essential for ensuring effective communication in legal, health, and religious contexts. Key government entities, such as the Language and Literature Bureau and the Ministry of Religious Affairs, managed translation units to support these functions. The analysis underscored how translation aligned with the national objectives of Brunei Vision 2035, aiming at a high-quality education, improved quality of life, and a sustainable economy. Results reveal that effective translation practices foster social cohesion, equitable access to public services, and national development. Continuous assessment, technological advancements, and human resource development are crucial for maintaining and enhancing the effectiveness of translation as an object of governance. Brunei’s case sheds light on the transformative potential of translation as a powerful tool for governance and holistic development, fostering cultural preservation and inclusivity. The research significantly contributes to the broader discourse on how effective translation governance can facilitate sustainable national progress and cross-cultural understanding.
Metaphorical Representation in Social Criticism in Indonesian Comedy
Authors: Langoday Yohanes Redan
Published: November 2024

The research aimed to investigate the metaphorical representations employed by comedians in delivering social criticism through Indonesian stand-up comedy. Metaphors played a crucial role in shaping how to understand and interpret social reality. Through metaphors, speakers or writers could frame subjects or concepts in ways that influence the audience’s perceptions and attitudes, perpetuating certain ideologies and power structures. Stand-up comedy prioritized the individual performer’s voice, but its success relied on the ability to make people laugh by tapping into shared cultural ideologies and societal power dynamics. Abdur Arsyad is an example of an Indonesian comedian who presents stand-up material containing social criticism of various societal issues and ideological assumptions. The research analyzed Arsyad’s comedy through Norman Fairclough’s threedimensional critical discourse analysis model of description, interpretation, and explanation of text, discursive practice, and sociocultural practice. The descriptive dimension examined how Arsyad used language to construct representations of the world shaped by ideology. The interpretative dimension analyzed how his language perpetuated or challenged power relations and social hierarchies. The explanatory dimension focused on how Arsyad’s representations of social identities were informed by dominant ideologies. A qualitative method wasapplied to obtain data from Arsyad’s performances on the KompasTV YouTube channel using documentation, library research, and note-taking techniques. The results reveal that Arsyad employs a range of metaphorical representations across Fairclough’s three textual values to critique and influence social norms and actions. Fairclough’s paradigm allows for a detailed examination of how comedy functions as social criticism, providing insights into the complex interplay between language, ideology, authority, and community.
Language Documentation Practices in Indonesia: A Critical Theory Perspective
Authors: Budiono Satwiko , Yanita Selly Rizki
Published: November 2024

The research examined the potential of language documentation practices in Indonesia. Using principles from critical theory, it argued that language documentation was different from language description, which was classified as monodisciplinary linguistics. Rather, language documentation had a broad scope of potential uses beyond descriptive linguistics. This was because language documentation could be linked to other linguistics fields such as sociolinguistics, oral tradition, oral history, and others. The core of language documentation was the natural language recordings that can be used in various fields, making language documentation part of interdisciplinary linguistics. Besides, multiple national and international institutions recognized its value. Meanwhile, language documentation in Indonesia was still closely linked to traditional descriptive or theoretical linguistics and was considered a data collection process rather than an independent field in linguistics. Furthermore, natural language recordings were still considered unscientific by the Indonesian academic community, especially in linguistics fields. This was because natural language recording could not be a final project for linguistics students or an output of linguistics research in Indonesia. Research output was still limited to products such as dictionaries, teaching materials, grammar, language maps, and so on. The research applied a descriptive qualitative approach. Data collection included close reading books, journals, and other relevant academic materials. Therefore, the research argues that natural language recordings should be considered a valid scientific activity as a final project for linguistics students or the output of linguistic research in Indonesia. Thus, the number of natural language recordings in Indonesia will increase in national and international repositories. In fact, this can contribute tolinguistic research because many linguistics scholars can utilize these language documentation results.
Indicação geográfica como vetor de promoção da sustentabilidade na era da sociedade de serviço
Authors: Marcolla Fernanda Analú , Arrabal Alejandro Knaesel
Published: November 2024

O artigo avalia o insituto jurídico da Indicação Geográfica e seu potencial para atuar como vetor de promoção das dimensões da sustentabilidade propostas por Sachs (1993) no contexto da sociedade de serviço. Com base nos dados levantados a partir de um conjunto de pesquisas realizadas sobre o tema na área do direito e da sustentabilidade, torna-se possível afirmar que a Indicação Geográfica de Serviço (IGS) pode ser um instrumento eficaz na promoção das cinco dimensões da sustentabilidade propostas por Sachs, quais sejam: econômica, ecológica, cultural, espacial e social. O estudo considera que a IGS, além de atuar como um catalisador para o desenvolvimento sustentável, também se configura como um instrumento eficaz para integrar e fomentar as cinco dimensões da sustentabilidade no contexto da sociedade de serviço. Ademais, a IGS pode ser um meio de assegurar direitos humanos, ao passo que incentiva a valorização e a preservação de saberes, práticas e patrimônios culturais locais, frequentemente vinculados a comunidades tradicionais ou em situação de vulnerabilidade. O método de pesquisa utilizado foi o hipotético-dedutivo, por meio da aplicação de técnicas de pesquisa bibliográfica e documental.
Descolonizar os direitos humanos: Um debate sobre letalidade juvenil, estado e terror
Authors: Marinho Camila
Published: November 2024

O objetivo desse texto é realizar uma reflexão acerca das práticas de violação dos direitos humanos, enunciadas por vozes das periferias, quando a violência institucional atravessa seus cotidianos, na qual, recorrentemente, as juventudes têm sido o principal alvo. Dessa forma, o conceito de ‘terrorismo de Estado” emerge como uma narrativa produzida pela dor, mas também como uma forma de alardear que a presença do Estado, de forma violenta nas periferias, coloca em risco, especialmente, a vida dos jovens pobres e pretos. Desse fato, a proposta é refletir sobre Estado, terror e letalidade juvenil, a partir de uma perspectiva decolonial dos direitos humanos, em diálogo com uma política de afetos fundamentada por uma ética amorosa como designa Bell Hooks, e pelo reconhecimento das diferenças como uma política enunciada por Nancy Fraser. Por fim, o caso em análise será a Chacina do Curió, um crime no qual 11 pessoas foram assassinadas, em sua maioria, jovens, que levou a julgamento profissionais da segurança pública da Polícia Militar do Ceará.
Neoliberalismo e ensino jurídico: Algumas reflexões sobre a educação enquanto força motriz para um (re)ascender democrático
Authors: Zambiasi Vinícius Wildner , Lyra José Francisco Dias da Costa
Published: November 2024

O presente ensaio aborda os impactos da razão de mundo neoliberal na sociedade e na democracia brasileira, bem como o papel que o ensino jurídico pode desempenhar tanto na emancipação do indivíduo, quanto para frear os intentos autoritários que circundam o Estado brasileiro e, consequentemente, trabalhar como força motriz do (re)ascender democrático. Para tanto, são investigadas as origens, características e consequências do neoliberalismo, seguida pela discussão acerca dos aspectos hodiernos da tendente precarização da educação jurídica. Ao final, conclui-se que somente um ensino jurídico crítico, humanista e plural, calcado no tripé de ensino, pesquisa e extensão, é que pode ser amplamente útil para a sociedade, na medida em que além de contemplar o direito fundamental à educação e, consequentemente, sustentar na formação do sujeito-cidadão, coletivo e comunitário, pode, ainda, auxiliar a solução dos problemas oriundos do não cumprimento das promessas da democracia, há tanto tempo já apontadas por Norberto Bobbio.
Water quality characterization for two lakes in Panchkula, Haryana, India
Authors: Vasistha Prachi , Ganguly Rajiv
Published: November 2024

The rising concerns surrounding water scarcity have prompted a closer examination of water sources to determine their suitability for various purposes based on their quality. Multivariate Statistical Analysis (MSA) is often used for grouping pollution sources based on their shared characteristics. Techniques such as Pearson's correlation coefficient analysis, Principal Component Analysis (PCA), and Hierarchical Cluster Analysis (HCA) are employed for in-depth parametric analysis. Additionally, the quantification of these parameters is carried out using both traditional Water Quality Index (WQI) methods and the newer Modified Water Quality Index (MWQI). For the present study, the MSA revealed elevated levels of electrical conductivity (EC), biochemical oxygen demand (BOD), and chemical oxygen demand (COD), primarily due to sediment influx from watershed areas and increased agricultural activities around the lakes. HCA indicated moderate pollution levels, further corroborated by the three selected WQI techniques. Overall, the water quality in both lakes was deemed ‘good’ across their entire expanse, suggesting they can be used directly for activities such as bathing, boating, and irrigation. However, for drinking purposes, some degree of treatment was still necessary.
Apresentação e Editoração
Authors: Silva Iransé Oliveira , Dutra e Silva Sandro , Sampaio Carlos Alberto Cioce
Published: November 2024

.
Percepción de barreras de género para el ejercicio del liderazgo en una universidad estatal de Chile
Authors: Suárez-Amaya Wendolin , Ganga-Contreras Francisco Anibal , Pérez Marcela Freire , Villegas Francisco Javier
Published: November 2024

Las barreras de género en la academia son un conjunto de obstáculos que limitan la participación equitativa de las mujeres en el ámbito académico. Estas barreras pueden manifestarse de diversas formas, desde las expectativas culturales y estereotipos de género hasta las políticas institucionales y prácticas cotidianas. El objetivo del estudio es analizar las percepciones sobre barreras de género de académicas que ocupan posiciones de liderazgo en una universidad estatal de Chile, para el comprender el desarrollo del liderazgo en este tipo de entidades educativas. El estudio utilizó una metodología cualitativa y descriptiva, interpretando la realidad según lo expresado por las participantes voluntarias. Como principales resultados, se identificaron barreras significativas para el liderazgo femenino, destacando la percepción de desigualdad de género y las dificultades en la participación y toma de decisiones. Las entrevistas revelaron que, aunque se han implementado políticas de género en las universidades chilenas, persisten desafíos como la cultura institucional, para asegurar una verdadera igualdad de oportunidades y desarrollo de mujeres en cargos de liderazgo universitario.  Los hallazgos sugieren consideraciones que pueden ser útiles para desarrollar estrategias más inclusivas en la gestión universitaria.
Entre humanitarismo y seguridad: la reorganización del control fronterizo en Chile (2010-2022)
Authors: Ramos Romina , Tapia Ladino Marcela
Published: November 2024

Desde 2010, el Estado chileno diseñó diversas estrategias con el fin de contener los flujos irregularizados e intentar sellar las fronteras del norte de Chile con normas y acciones de control fronterizo sobre perfiles de personas consideradas de “riesgo”, así como con el reforzamiento del control fronterizo bajo el supuesto de proteger a los migrantes más vulnerables. Este artículo analiza la reorganización del control fronterizo en Chile y sus efectos en la producción de irregularidad migratoria a partir del análisis de reportes nacionales oficiales sobre los rechazos en frontera y datos de expulsiones de extranjeros e ingresos por pasos no habilitados hasta 2022. Se concluye que, más allá de la narrativa estatal sobre el combate al crimen organizado y su versión humanitaria de la movilidad, se habilitaron estrategias selectivas de contención de flujos que reorganizaron el control fronterizo con acento securitario lo que aumentó la irregularidad migratoria y criminalizó las movilidades transnacionales.
CHANGE IN THE PHASE RELATIONSHIP OF THE ARTERIAL PRESSURE AND HEART RATE OSCILLATIONS DURING ORTHOSTASIS: THE EFFECT OF GRAVITATIONAL UNLOADING
Authors:   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Borovik A.S. , Pavlova Е.А. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Zhediaev R.Yu. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Rukavishnikov I.V. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Tarasova O.S. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Vinogradova O.L. ,   Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow
Published: November 2024

Investigation of the amplitude characteristics of arterial pressure (AP) and heart rate (HR) within the low-frequency (LF) band (baroreflex waves, ~ 0.1 Hz) and high-frequency (HF) band (breathing rate) is commonly used to asses the cardiovascular system functioning. This work was concerned with the effects of 7-d dry immersion (DI) (period of distinct hemodynamic shifts) on the phase characteristics of AP and HR oscillations within the LF and HF bands during the orthostatic test. Eight young healthy male subjects were exposed to the passive tilt test, i.e. 15 min in supine position followed by 15-min tilt at 60°. During the test, ECG, AP and breathing rate were registered continuously; breathing rate was set by the vocal command from PC. Breathing control and data analysis were performed using a specially developed program. It was found that orthostasis increased synchronization of the AP and HR oscillations within the LF band and also reduced the phases difference (temporal shift) between the oscillations within the HF band. Disappearance of these changes after DI reflects deterioration of the cardiac rhythm control by the nervous system. The comprehensive analysis of the AP and HR phase relations within the LF and HF bands can be useful for assessing changes in nervous regulation of the heart during gravitational unloading, diagnostics of orthostatic instability due to cardiovascular diseases, and developing methods of prevention.
An Innovative Telomere-associated Prognosis Model in AML: Predicting Immune Infiltration and Treatment Responsiveness
Authors: Song Binyang , Lou Jinzhan , Mu Lijun , Lu Xiao , Sun Jian , Tang Bo
Published: November 2024

Aims:

To build an innovative telomere-associated scoring model to predict
prognosis and treatment responsiveness in acute myeloid leukemia (AML).

Background:

AML is a highly heterogeneous malignant hematologic disorder with a
poor prognosis. While telomere maintenance is frequently observed in tumors, investigations
into telomere-related genes (TRGs) in AML remain limited.

Objectives:

This study aimed to identify prognostic TRGs using the least absolute shrinkage
and selection operator (LASSO) Cox regression and multivariate Cox regression,
evaluate their predictive value, explore the association between TRG scores and immune
cell infiltration, and assess the sensitivity of high-scoring AML patients to chemotherapeutic
agents.

Method:

Univariate Cox regression analysis was conducted on the TCGA cohort to identify
prognostic TRGs and to develop the TRG scoring model using LASSO-Cox and
multivariate Cox regression. Validation was performed on the GSE37642 cohort. Immune
cell infiltration patterns were assessed through computational analysis, and the sensitivity
to chemotherapeutic agents was evaluated.

Results:

Thirteen prognostic TRGs were identified, and a seven-TRG scoring model (including
NOP10, OBFC1, PINX1, RPA2, SMG5, MAPKAPK5, and SMN1) was developed.
Higher TRG scores were associated with a poorer prognosis, as confirmed in the
GSE37642 cohort, and remained an independent prognostic factor even after adjusting
for other clinical characteristics. The high-score group was characterized by elevated infiltration
of B cells, T helper cells, natural killer cells, tumor-infiltrating lymphocytes,
regulatory T (Treg) cells, M2 macrophages, neutrophils, and monocytes, along with reduced
infiltration of gamma delta T cells, CD4- T cells, and resting mast cells. Moreover,
high infiltration of M2 macrophages and Tregs was associated with poor overall
survival compared to low infiltration. Notably, high-risk AML patients were resistant to
Erlotinib, Parthenolide, and Nutlin-3a, but sensitive to AC220, Midostaurin, and Tipifarnib.
Additionally, using RT-qPCR, we observed significantly higher expression of
two model genes, OBFC1 and SMN1, in AML tissues compared to control tissues.

Conclusion:

This innovative TRG scoring model demonstrates considerable predictive
value for AML patient prognosis, offering valuable insights for optimizing treatment
strategies and personalized medicine approaches. The identified TRGs and associated
scoring models could aid in risk stratification and guide tailored therapeutic interventions
in AML patients.
Preparation of DOX-TPP/HA-ss-OA Nanoparticles, Investigation of Drug Release Behavior In Vitro, and Evaluation of Anti-proliferative Activity
In Vitro
Authors: Fei Xuanting , Hu Qiaohong
Published: November 2024

Objective:

This study aimed to develop and characterize DOX-TPP/HA-ss-OA nanoparticles,
utilizing the mitochondria-targeting prodrug doxorubicin-triphenylphosphine (DOXTPP)
and a reduction-sensitive amphiphilic polymer, hyaluronic acid-disulfide-oleic acid (HAss-
OA). The research focused on evaluating the drug release behavior of these nanoparticles under
varying glutathione (GSH) concentrations and their anti-tumor activity in vitro.

Methods:

DOX-TPP/HA-ss-OA nanoparticles were prepared using probe ultrasound technology.
The study examined the impact of different organic solvents on drug loading capacity and encapsulation
efficiency to determine the optimal conditions. A single-factor experimental design was
used to optimize the formulation process. Key parameters, including particle size and zeta potential,
were measured to assess nanoparticle stability and performance. The dynamic dialysis
method was employed to evaluate the reduction-sensitive drug release characteristics in media
with different GSH concentrations. The MTT assay was used to analyze the growth-inhibitory
effects of the nanoparticles on human breast cancer cells (MCF-7) and drug-resistant cells
(MCF-7/ADR).

Results:

The optimized preparation process for DOX-TPP/HA-ss-OA nanoparticles included a
drug dosage of 2.0 mg, an oil-to-water volume ratio of 1:5, ultrasonic power of 500 W, and ultrasonic
time of 15 minutes. The nanoparticles had an average particle size of 203.72 ± 2.30 nm
and a zeta potential of 25.82 ± 0.58 mV, indicating favorable stability and effective drug delivery
properties. The nanoparticles exhibited a slow, sustained release of DOX-TPP in pH 7.4 phosphate
buffer solution (PBS) and accelerated release in high GSH concentrations, demonstrating
reduction-responsive drug release. In vitro studies showed that DOX-TPP/HA-ss-OA nanoparticles
significantly inhibited the proliferation of MCF-7 and MCF-7/ADR cells in a dosedependent
manner, with enhanced efficacy compared to free DOX and other formulations.

Conclusion:

DOX-TPP/HA-ss-OA nanoparticles demonstrate excellent reduction sensitivity, effective
tumor cell growth inhibition in vitro, and the ability to overcome drug resistance. Including
particle size and zeta potential measurements supports their suitability as drug carriers, highlighting
their potential for targeted cancer therapy and further development.
Myotoxicity of Crotoxin on C2C12 Myoblasts and its Inhibition by Crotalus Neutralizing Factor versus Enhanced Resistance in Myotubes: Exploring Toxicity and Membrane Potential
Authors: Tavares Maria Naiara Macedo , Eulálio Micaela de Melo Cordeiro , Santana Hallison Mota , Boeno Charles Nunes , Reis Valdison Pereira dos , Alves Rego Cristina Matiele , Ferreira e Ferreira Alex Augusto , Paloschi Mauro Valentino , Soares Andreimar M. , Fortes-Dias Consuelo Latorre , Setúbal Sulamita Silva , Zuliani Juliana Pavan
Published: November 2024

Background:

Crotalus Neutralizing Factor (CNF) is a γ-type Phospholipase A2 (PLA2)
inhibitor present in the blood of Crotalus durissus terrificus snake. Particularly, CNF inhibits the
toxic action of Crotoxin (CTX), which is a major neurotoxin found in C. d. terrificus venom. CTX
induces also myotoxic action and demonstrates high selectivity for skeletal muscle fibers. Consequently,
CTX can diffuse beyond the site of infection, which can potentially evoke rhabdomyolysis.
The present study has evaluated the effects of CTX on myoblasts and myotubes of muscle
cells C2C12 in vitro and the effect of CNF on CTX-induced damage.

Methods:

Cytotoxicity assays were performed by measuring the mitochondrial enzyme dehydrogenase
levels. Furthermore, creatine kinase and lactate dehydrogenase levels were used as indicators
of muscle damage.

Results:

Crotoxin has been found to have cytotoxic effects on C2C12 myoblast cells, while CNF
has not shown toxic effects on these cells. Furthermore, the findings have shown CNF (50 μg/mL)
to abolish CTX toxicity in myoblasts. The myotubes, differentiated cells, showed no change in mitochondrial
respiration when exposed to CNF or CTX, showing greater resistance to the toxic actions
of crotoxin.

Conclusion:

The data have confirmed the potential of CNF as an anti-myotoxic agent to prevent
CTX-damaged myoblasts and increase resistance to the toxic effects of crotoxin on differentiated
cells.
Carbamazepine-induced Stevens-Johnson Syndrome: A Case Report with Review of the Literature
Authors: Subramanian Arunkumar , Haitharali Rajamohamed , S Nirenjen , T Tamilanban , Dhansekaran Sivaraman , Gnanasekaran Sabariakilesh , Manavalan Mohankumar , Raja Sangeetha
Published: November 2024

Background:

Stevens-Johnson Syndrome (SJS) is an infrequent yet severe mucocutaneous
reaction that involves less than 10% of the Body Surface Area (BSA). It is predominantly
induced by certain medications, including anticonvulsants (e.g., Lamotrigine, Carbamazepine,
Phenytoin, Phenobarbitone), Allopurinol at doses above 100 mg per day, and sulphonamides
(e.g., Cotrimoxazole, Sulfasalazine). Genetic predispositions, particularly the presence of the
HLA-B*1502 allele, significantly increase the risk of developing SJS. This case report discusses
a unique presentation of SJS in a young female patient, emphasizing the critical need for genetic
screening and careful monitoring when prescribing Carbamazepine, especially in populations at
higher genetic risk.

Case Presentation:

A 19-year-old female patient, who had been on Phenytoin and Sodium
Valproate for epilepsy management over the past year, was newly prescribed Carbamazepine.
Within a week of initiating Carbamazepine, the patient experienced a seizure, followed by the
sudden onset of fever, painful sores, and blisters covering the upper body, along with mucous
discharge from both eyes. These symptoms rapidly worsened. Based on clinical presentations
and the extent of epidermal detachment, the patient was diagnosed with SJS. The severity and
mortality risks were assessed using the SCORTEN score. Therapeutic interventions included intravenous
Ranitidine, Ondansetron, Paracetamol, Midazolam, Levetiracetam, and Dexamethasone,
along with oral Fluconazole, Chlorpheniramine tablets, and Ciprofloxacin eye drops.
The patient showed significant improvement and was discharged after fourteen days with followup
advice.

Conclusion:

This case underscores the critical importance of performing genetic testing for the
HLA-B*1502 allele and conducting baseline blood tests before initiating Carbamazepine therapy.
Such precautionary measures can significantly mitigate the risk of severe adverse reactions
like SJS. This report adds to the scientific literature by highlighting the potential dangers associated
with anticonvulsant therapies and the necessity for personalized medicine approaches in
preventing life-threatening conditions. The main takeaway is the pivotal role of genetic screening
and vigilant monitoring in the management of patients requiring anticonvulsant medications to
prevent serious adverse reactions.
Composition and Biological Activity of Flavonoid-containing Fractions of an Extract
from Gratiola officinalis L.
Authors: Shirokov Alexander , Grinev Vyacheslav , Kanevskiy Matvey , Fedonenko Yulia , Matora Larisa , Polukonova Natalya , Mudrak Dmitry , Mylnikov Artyom , Polukonova Anna , Bucharskaya Alla , Navolokin Nikita , Maslyakova Galina
Published: November 2024

Introduction:

Gratiola officinalis L. (hedge hyssop), a medicinal plant of the Scrophulariaceae family,
has diuretic, purgative, and vermifuge properties. It is used as a herbal tea to treat chronic gastroenteritis, renal
colic, jaundice, and intestinal worms. Previously, we have found that an extract from G. officinalis is nontoxic
and has antitumor, antioxidant, antimicrobial, antiinflammatory, anticachexic, and other properties. Our aims in
this study were to separate the G. officinalis extract into individual fractions, to identify the most biologically
active fractions, and to examine the chemical composition of these fractions and their biological activity toward
A498 renal carcinoma cells.

Methods:

The G. officinalis extract was fractionated by reversed-phase high-performance liquid chromatography,
and each fraction was tested for antitumor activity. The active fractions were characterized by UV-visible electron
spectral analysis, circular dichroism analysis, Fourier transform infrared spectroscopy, high-performance
liquid chromatography, electrospray ionization tandem mass spectrometry, and nuclear magnetic resonance spectroscopy.

Results:

Two antitumor-active fractions of a flavonoid nature were isolated and chromatographically purified. On
the basis of the nuclear magnetic resonance data, the aglycone fragment of the main component of one fraction
was found to be structured as 2-(3,4-dimethoxyphenyl)-7-hydroxychroman-4-one, or 3',4'-dimethoxy-7-
hydroxyflavanone.

Conclusion:

The antitumor effect of the most active fraction containing 7-O-glucoside of apigenin, glycoside
7,3'-di-O-luteolin and trace amounts of eupatilin against renal carcinoma A498 cells was manifested in its cytotoxic,
cytostatic, apoptotic and autophagosomal activities. In addition, we found 3-(1-2)-glucoside of
soyaspogenol B, which is a pentacyclic triterpenoid in the structure.
Cardio-metabolic Disorders Affected by Genetic Polymorphisms Related to Premature Menopause
Authors: Mirinezhad Mohammad Reza , Bana Hamideh Safarian , Aghsizadeh Maliheh , Mohammadi Mohammad Amin , Ghazizadeh Hamideh , Dabagh Ali Ebrahimi , Mir Nourbakhsh Sayyedeh Helya , Shahvandi Hassan Kiani , Ghodsi Alireza , Aghsizadeh Mahdie , Taghipour Faezeh , Hasanzadeh Elahe , Andalibi Nazanin Sheikh , Khedmatgozar Hamed , Ferns Gordon A. , Hamzehloei Tayebeh , Pasdar Alireza , Ghayour-Mobarhan Majid
Published: November 2024

Background:

Premature menopause (PM) is defined as the end of ovulation before the
age of 40 years, a condition commonly referred to as primary ovarian insufficiency. It has been
shown there is an association between early menopause and a high risk of cardiovascular disease.

Aim:

This study aimed to evaluate the effect of genetic polymorphisms related to premature menopause
on cardio-metabolic disorders

Objective:

We aimed to investigate the single nucleotide polymorphisms associated with PM and
the risk of cardio-metabolic disorders in the MASHAD cohort study.

Methods:

In this cross-sectional study, a total of 117 women with PM were recruited and compared
with 183 healthy women. All participants were assessed for anthropometric indices and
genotyped for eight selected polymorphisms within seven different genes.

Results:

A significant difference was observed in physical activity level (PAL) between the
groups. Individuals with rs4806660 CC genotype had a 3.63-fold increased risk of metabolic syndrome.
Moreover, individuals with a TT genotype of the rs2303369 polymorphism had a 3.11--
fold increased risk of obesity.

Conclusion:

Our findings showed that genetic variations are risk factors related to cardio-
metabolic disorders in women with premature menopause.

other:

Cardio-metabolic disorders affected by genetic polymorphisms related to premature menopause
Recent Advancement in Pyrazole Derivatives as Antimalarial Agents and their SAR Study
Authors: Paliwal Deepika , Thakur Aman , Sahu Rakesh , Shah Kamal , Rao GSN Koteswara
Published: November 2024

Malaria is caused by protozoan parasites and is a significant contributor to global
mortality and morbidity. The main reasons for the resurgence of malaria are the emergence of
drug-resistant strains of the parasite and the ineffectiveness of current treatment. Pyrazole-based
drugs play a crucial role in medicinal chemistry due to their diverse pharmacological properties.
The pyrazole structure, a five-membered ring with two nitrogen atoms, is a key pharmacophore
in various therapeutic agents. Numerous derivatives of pyrazole scaffold exhibited a wide range
of pharmacological activity such as analgesics, antiinflammatory, antioxidant, antimicrobial, antidiabetic,
anticancer, antiviral, antifungal, and antithrombotic activities. These drugs provide
numerous opportunities for enhancing antimalarial agents by targeting various critical receptors.
Various pyrazole derivatives have been reported to inhibit enzymes, receptors, and other targets
to manage malaria. These derivatives inhibited parasite through various mechanisms such as
falcipain, dihydrofolate redcutase, dihydroorotate dehydrogenase, lactate dehydrogenase, protein
kinase, calcium dependent protein kinase, glycogen synthase kinase, and histo aspartic protease.
Currently, researchers are developing new pyrazole-based derivatives, often in combination
with other moieties, for improved malaria treatment. This review highlights the recent therapeutic
advancements of pyrazole, including its structure-activity relationship, molecular docking,
commercial drug availability, and a summary of recent research publications, all of which
collectively assist scientists in developing effective drugs with desired pharmacological activities.
Synthesis, Characterization, and Anticancer, Antidiabetic, and Antimicrobial Activities of Azo-Schiff Base Ligand with ONO Donor Atom and its Transition Metal Complexes
Authors: Sakhare Kuldeep Bhaskar , Sakhare Mahadeo Abarao , Sarwade Kirti Navnath , Bharate Yogesh Navnath
Published: November 2024

Introduction:

Cancer, diabetes, and infection of bacteria and fungi are serious issues
in the world. Synthesis of the potential drugs against them is a major challenge to the researcher.
Hence, coordination chemistry has attracted researchers as it has various applications
in medicinal and biological fields.

Methods:

Synthesis and biological evolution of azo-Schiff base ligand and its Mn(II), Co(II),
Ni(II), Cu(II), Zn(II), and VO(II) metal complexes were carried out. These compounds were
characterized by Mass, 1H-NMR, FT-IR, Elemental analysis, Molar conductance, Magnetic
susceptibility, UV-Vis., P-XRD, TGA, etc., and were screened for biological activities.

Result:

Synthesised azo-Schiff base ligand and its metal complexes were evaluated for their
antimicrobial, antidiabetic as well as anticáncer activities against various bacteria and fungi
and MCF-7 breast cancer cell line, respectively.

Conclusion:

From the findings of various results, we can conclude that the synthesized metal
complexes exhibit higher biological activities than the azo-Schiff base ligand.
Research on the Warm Mixing Effect and Evaluation Method of WMA-DSBS Modified Asphalt
Authors: Shi Silin , Wu Di , Yang Jixu , Yan Xiang , Zhang Wengang , Cui Lilong
Published: November 2024

Background:

Traditional SBS-modified asphalt consumes a large amount
of energy during the production process. WMA-DSBS-modified asphalt can reduce
the mixing temperature, which is crucial for reducing energy consumption.

Objectives:

The aim of this study was to reduce the mixing temperature as much as
possible without compromising the performance of the asphalt mixture while saving
energy consumption and protecting the environment. By evaluating the warm mixing
effects of different warm mixing types applied to direct-to-plant SBS (DSBS) modified
asphalt, as well as the changes in road performance after warm mixing DSBS
modified asphalt mixture, reference opinions are provided for the dosage of warm
mixing agents in engineering problems.

Method:

A comparison is made between DSBS-modified asphalt and warm mix
DSBS-modified asphalt in terms of technical performance parameters. On the basis of
the Brinell rotational viscosity test and the variable temperature compaction test, an
index system for evaluating the modification effect of warm-mixed asphalt was developed.

Result:

The research results indicated that three different warm mixing agents have
an enhancing effect on the temperature sensitivity, high-temperature performance,
and low-temperature plastic deformation ability of asphalt in some temperature ranges.
The viscosity of DSBS modified asphalt decreases with the increase of temperature
before and after the addition of the three warm mix agents. During the temperature
increase process, the viscosity reduction index K value changes from negative to
positive; The dosage of warm mixing agent is negatively correlated with the porosity
of WMA-DSBS modified asphalt mixture, and as the temperature increases, the porosity
of the mixture will decrease. The performance value T shows an upward trend,
improving its road performance.

Conclusion:

A reasonable dosage of warm mix agent can significantly reduce the
mixing temperature, therefore WMA-DSBS modified asphalt plays an important role
in reducing energy consumption.
Navigating Biosimilar Regulatory Pathways in Emerging Markets: Insights from BRICS Nations
Authors: Patil Niraj , Ranjan Animesh , Gaurav  , Mukherjee Debanjan , Panda Brajesh Kumar , Diksha  , Komal  , Narang Raj Kumar , Singh Amandeep
Published: November 2024

This comprehensive review delves into the intricate landscape of biosimilars, offering
a nuanced exploration of their background, pivotal role in emerging markets like BRICS,
and the multifaceted considerations spanning regulatory, quality, manufacturing, pricing, reimbursement,
intellectual property, pharmacovigilance, and future trends. The backdrop on
biosimilars unravels their significance as a transformative force in healthcare, providing costeffective
alternatives to biologics. The focus then shifts to the emerging markets encapsulated
by BRICS, where economic and healthcare landscapes are pivotal determinants in shaping the
biosimilar ecosystem. Navigating the regulatory landscape becomes imperative for biosimilar
developers, and an overview of regulatory agencies within BRICS underscores the need for
harmonized guidelines. Delving deeper, the paper outlines the intricate registration requirements,
providing insights into key considerations pivotal for successful biosimilar submissions.
Quality, manufacturing, and marketing of biosimilars form a critical triad. Quality attributes
and similarity assessments, coupled with analytical methods and characterization,
emerge as focal points ensuring the safety and efficacy of these biologic counterparts. Pricing,
reimbursement, and market access, the linchpin for successful biosimilar integration, are dissected
comprehensively. Pricing policies and strategies, reimbursement considerations, and
the plethora of challenges and opportunities associated with market access are examined, offering
a holistic understanding of the economic dynamics at play. The intellectual property
landscape, delineated through patent regulations, data exclusivity, challenges, and litigation,
adds a layer of complexity to biosimilar development and market entry. Pharmacovigilance
and post-marketing surveillance emerge as crucial pillars ensuring the ongoing safety of biosimilars.
Safety monitoring, risk management plans, and post-marketing surveillance requirements
are essential components in this ever-evolving field. The exploration culminates in
case studies and market insights, providing tangible examples of successful biosimilar submissions
and approvals within the BRICS nations. This segment unveils the current market
dynamics, competitive landscapes, and the intricacies of navigating these diverse markets.
Looking forward, the paper outlines potential growth prospects and anticipates future trends
and opportunities in the biosimilar landscape. It concludes by addressing the evolving policy
and regulatory developments, offering stakeholders a comprehensive guide for navigating the
dynamic and promising future of biosimilars within the BRICS nations. This work serves as a
vital resource for industry professionals, policymakers, and researchers involved in the intricate
journey of biosimilar development and market access.
PENGEMBANGAN E-LKPD BERBASIS PBL MATERI HORMON REPRODUKSI UNTUK MENINGKATKAN LITERASI KESEHATAN REPRODUKSI
Authors: Cahyani Danisa Naya , Pertiwi Kartika Ratna
Published: November 2024

Penelitian ini bertujuan untuk 1) mengetahui karakteristik LKPD elektronik (e-LKPD) berbasis Problem Based Learning pada materi hormon dalam sistem reproduksi manusia, 2) mengetahui kelayakan LKPD elektronik (e-LKPD) berbasis Problem Based Learning apabila digunakan dalam pembelajaran, 3) mengetahui efektivitas e-LKPD berbasis Problem Based Learning untuk meningkatkan literasi kesehatan reproduksi. Penelitian ini merupakan penelitian pengembangan dengan mengadaptasi model pengembangan 4D, yaitu define, design, dan develop. Pengembangan e-LKPD memanfaatkan website liveworksheets yang dapat diakses secara online. Desain uji coba e-LKPD berbasis PBL menggunakan one group pretest posttest design. Instrumen pengumpulan data menggunakan lembar penilaian kelayakan oleh ahli, lembar penilaian kelayakan oleh guru, angket respon peserta didik, soal literasi pengetahuan, dan angket literasi sikap. Data dianalisis menggunakan analisis deskriptif dan inferensial (uji paired T test dan uji Wilcoxon). Hasil penelitian ini berupa produk e-LKPD berbasis PBL yang layak digunakan pada pembelajaran biologi materi hormon dalam sistem reproduksi manusia. Selain itu, e-LKPD berbasis PBL ini efektif digunakan untuk meningkatkan literasi kesehatan reproduksi peserta didik.
PENGEMBANGAN GAME EDUKASI BERBASIS APLIKASI ANDROID UNTUK MELATIH LITERASI DIGITAL DAN KETERAMPILAN ARGUMENTASI ILMIAH SISWA KELAS X SMA PADA MATERI VIRUS DAN PERANANNYA
Authors: Putri Nada Oktavia , Akmalia Hafidha Asni , Tauhidah Dian
Published: November 2024

Keterampilan abad 21 melalui pendidikan holistik menjadi suatu hal penting yang tidak dapat diabaikan, terutama seiring dengan perkembangan era digital yang mengubah paradigma pembelajaran di mana kebutuhan akan keterampilan seperti literasi digital, pemecahan masalah, kreativitas, dan kolaborasi semakin mendesak serta tidak hanya mengandalkan pengetahuan tetapi keterampilan ikut berperan dalam pembelajaran abad 21. Penelitian ini bertujuan untuk mengembangkan, menganalisis kelayakan, dan keterbacaan dari produk game edukasi berbasis aplikasi android untuk melatih literasi digital dan keterampilan argumentasi ilmiah siswa kelas X SMA pada materi virus dan peranannya. Jenis penelitian yang digunakan pada penelitian ini adalah penelitian pengembangan (Research and Development) dengan model pengembangan 4-D yang mencakup tahapan yaitu Define (Pendefinisian), Design (Perancangan), dan dibatasi pada Develop (Pengembangan). Hasil dari produk yang dikembangkan berupa game edukasi berbasis aplikasi android. Berdasarkan hasil uji validasi, diperoleh nilai kelayakan sebesar 77,03% dari ahli media, 89,5% dari ahli materi, 82,5% dari ahli literasi digital, 86,66% dari ahli argumentasi ilmiah, dan 87,93% dari respon guru Biologi. Uji keterbacaan dari respon siswa dengan uji skala kecil sebesar 83,46% dari hasil  uji skala kecil. Berdasarkan perolehan hasil uji dapat disimpulkan bahwa, media game edukasi berbasis aplikasi android untuk melatih literasi digital dan keterampilan argumentasi ilmiah siswa kelas X SMA pada materi virus dan peranannya dikategorikan sangat layak dan valid untuk digunakan.
Nanostructure-Based Solid-State Energy Storage through Hydrogen Trapping in Batteries Using Materials Modelling Technique
Authors: Mollaamin Fatemeh
Published: November 2024

A comprehensive investigation on hydrogen grabbing by SiO-GeO was carried out, including DFT computations at the CAM-B3LYP-D3/6-311+G (d,p) level of theory. The data shows that if silicon elements are replaced by germanium, the H-grabbing energy will be ameliorated. Electromagnetic and thermodynamic properties of SiO, GeO, and SiO-GeO nanoclusters have been evaluated. The hypothesis of the hydrogen adsorption phenomenon was confirmed by density distributions of PDOS and LOL for hydrated nanoclusters of H-SiO, H-GeO, and H-SiO-GeO-H. The fluctuation in charge density values demonstrates that the electronic densities were mainly located in the boundary of adsorbate/adsorbent atoms during the adsorption status. The advantages of germanium over silicon include its higher electron and hole mobility, allowing germanium devices to operate at higher frequencies than silicon devices. Therefore, by combining SiO and GeO, it can be concluded that the SiO-GeO nanocluster might be an appropriate candidate for hydrogen storage in transistors.
Exploring the Use of Activity Trackers to Support Physical Activity and Reduce Sedentary Behavior in Adults Diagnosed With Type 2 Diabetes: Qualitative Interview Study Using the RE-AIM Framework
Authors: Hodgson William , Kirk Alison , Lennon Marilyn , Janssen Xanne
Published: November 2024

Background

The prevalence of type 2 diabetes in adults worldwide is increasing. Low levels of physical activity and sedentary behavior are major risk factors for developing the disease. Physical activity interventions incorporating activity trackers can reduce blood glucose levels in adults diagnosed with type 2 diabetes. The My Diabetes My Way website is a support and educational platform for people diagnosed with diabetes and health care professionals. Users of the My Diabetes My Way website can upload their Fitbit (Google Inc) activity data into the system but this is not presently being analyzed and used routinely within clinical care. Developers of the My Diabetes My Way system are planning to allow different makes of activity trackers to be integrated with the platform.

Objective

This qualitative study aimed to explore (through the RE-AIM [reach, effectiveness, adoption, implementation, and maintenance] framework) views from adults diagnosed with type 2 diabetes and health care professionals on the integration of activity trackers into type 2 diabetes care.

Methods

Overall, 12 adults diagnosed with type 2 diabetes and 9 health care professionals (4 general practitioners, 1 consultant, 2 diabetes nurses, 1 practice nurse, and 1 physical activity advisor) were recruited through social media and professional contacts. Semistructured one-to-one interviews were conducted. Abductive thematic analysis was undertaken, and main themes and subthemes were identified. The RE-AIM framework was used to evaluate the themes with respect to the wider use of activity trackers and the My Diabetes My Way platform within type 2 diabetes clinical care.

Results

Overall, 6 main themes (awareness, access, cost, promotion, support, and technology and data) and 20 subthemes were identified. Evaluation using the 5 RE-AIM dimensions found that reach could be improved by raising awareness of the My Diabetes My Way platform and the ability to upload activity tracker data into the system. Effectiveness could be improved by implementing appropriate personalized measures of health benefits and providing appropriate support for patients and health care staff. Adoption could be improved by better promotion of the intervention among stakeholders and the development of joint procedures. Implementation could be improved through the development of an agreed protocol, staff training, and introducing measurements of costs. Maintenance could be improved by supporting all patients for long-term engagement and measuring improvements to patients’ health.

Conclusions

Through this study, we identified how the reach, effectiveness, adoption, implementation, and maintenance of integrating activity trackers into adult type 2 diabetes care could be improved.