bluuebunny/crossref_metadata_2025 huggingface dataset:
Joint Power Allocation for Coordinated Multi-Point Diversity Transmission in Rayleigh Fading Channels
Authors: Lee Min , Oh Seong-Keun
Published: January 2019

We consider the problem of joint power allocation (JPA) in a coordinated multi-point (CoMP) joint diversity transmission (JDT) network with a total coordination point power (TCPP) constraint, aimed at maximizing the ergodic cooperative capacity (ECC) in Rayleigh fading channels. In this paper, we first extend the JPA problem in the coordinated two-point (Co2P) JDT networkto the case of a non-unity TCPP constraint. Furthermore, we introduce more accurate log-quadratic approximated (LQA) expressions to obtain the coordinated transmission point (CTP) powers. Next, we extend our study to a coordinated three-point (Co3P) JDT network. Given the mean branch gain-to-noise ratios, we first obtain a log-linear approximated (LLA) expression for obtaining the optimum power of the third CTP (i.e., the worst quality-providing CTP). After obtaining the third-CTP power, we obtain the CTP powers of two better quality-providing CTPs by invoking the LLA CTP power expressions for Co2P JDT power allocation, under the remaining power given by the TCPP minus the third-CTP power. The numerical results demonstrate that the LQA and LLA CTP power expressions for Co2P JDT and the LLA CTP power expressions for Co3P JDT are very efficient in terms of the simplicity for JPA and CoMP set selection, as well as the resulting ECC.
Logging Contractors’ Growth in the Southern Cone: An Analysis of Contractor Business Strategies, Innovation, and Mechanization
Authors: Mac Donagh Patricio , Velazco Santiago José Elías , Botta Guido F. , Schlichter Tomas , Cubbage Frederick
Published: January 2019

Forest plantations have increased in South America for several decades. Harvesting is performed mainly through contractor companies. Our hypothesis is that logging contractors that innovate, grow more than others. We analyzed logging contractors through production and innovation, working in Argentina (22), Brazil (35) and Uruguay (10), through surveys between 2008 and 2012. Factors that affected firm growth were analyzed with linear mixed effect models. In all three countries there was a preponderance of logging contractors with cellulose companies. Our results show that logging firms that had mutualistic supply chain relations with the contracting organizations had better production indicators and lower cost per ton than other independent harvesting contractors. In the last 10 years, mechanization increased significantly, reducing the number of employees. Innovation was the most significant variable in enhanced logging production. For the period from 10 to 5 years before the survey period, the number of employees and type of contracting company were most significant on loggers’ growth. During the last 5-year period before the survey period, the number of employees and innovation were significant. Thus, during the last 10 years, logging companies shifted from growth based on type of the firm to the amount of innovation by firms, and contracting companies.
Effects of Lewis Number on the Evolution of Curvature in Spherically Expanding Turbulent Premixed Flames
Authors: Alqallaf Ahmad , Klein Markus , Chakraborty Nilanjan
Published: January 2019

The effects of Lewis number on the physical mechanisms pertinent to the curvature evolution have been investigated using three-dimensional Direct Numerical Simulation (DNS) of spherically expanding turbulent premixed flames with characteristic Lewis number of L e = 0.8 , 1.0 and 1.2. It has been found that the overall burning rate and the extent of flame wrinkling increase with decreasing Lewis number L e , and this tendency is particularly prevalent for the sub-unity Lewis number (e.g., L e = 0.8 ) case due to the occurrence of the thermo-diffusive instability. Accordingly, the L e = 0.8 case has been found to exhibit higher probability of finding saddle topologies with large magnitude negative curvatures in comparison to the corresponding L e = 1.0 and 1.2 cases. It has been found that the terms in the curvature transport equation due to normal strain rate gradients and curl of vorticity arising from both fluid flow and flame normal propagation play pivotal roles in the curvature evolution in all cases considered here. The net contribution of the source/sink terms of the curvature transport equation tends to increase the concavity and convexity of the flame surface in the negatively and positively curved locations, respectively for the L e = 0.8 case. This along with the occurrence of high and low temperature (and burning rate) values at the positively and negatively curved zones, respectively acts to augment positive and negative curved wrinkles induced by turbulence in the L e = 0.8 case, which is indicative of thermo-diffusive instability. By contrast, flame propagation effects tend to weakly promote the concavity of the negatively curved cusps, and act to decrease the convexity of the highly positively curved bulges in the L e = 1.0 and 1.2 cases, which are eventually smoothed out due to high and low values of displacement speed S d at negatively and positively curved locations, respectively. Thus, flame propagation tends to smoothen the flame surface in the L e = 1.0 and 1.2 cases.
Effects of Harvest Time on the Aroma of White Wines Made from Cold-Hardy Brianna and Frontenac Gris Grapes Using Headspace Solid-Phase Microextraction and Gas Chromatography-Mass Spectrometry-Olfactometry
Authors: Rice Somchai , Tursumbayeva Madina , Clark Matthew , Greenlee David , Dharmadhikari Murlidhar , Fennell Anne , Koziel Jacek A.
Published: January 2019

The Midwest wine industry has shown a marked increase in growers, hectares planted, wineries, and wine production. This growth coincides with the release of cold-hardy cultivars such as Brianna and Frontenac gris, in 2001 and 2003, respectively. These white grape varieties account for one-third of the total area grown in the state of Iowa. It is generally accepted that the wine aroma profile plays a crucial role in developing a local, sustainable brand. However, the identity of Brianna/Frontenac Gris-based wine aromas and their link to the grape berry chemistry at harvest is unknown. This study aims to preliminarily characterize key odor-active compounds that can influence the aroma profile in wines made from Brianna and Frontenac gris grapes harvested at different stages of ripening. Brianna and Frontenac gris grapes were harvested approximately 7 days apart, starting at 15.4 °Brix (3.09 pH) and 19.5 °Brix (3.00 pH), respectively. Small batch fermentations were made for each time point with all juices adjusted to the same °Brix prior to fermentation. Odor-active compounds were extracted from wine headspace using solid-phase microextraction (SPME) and analyzed by gas chromatography-mass spectrometry (GC-MS) and simultaneous olfactometry (O). Over 30 odor-active compounds were detected. Aromas in Brianna wines developed from “cotton candy” and “floral”, to “banana” and “butterscotch”, then finally to “honey”, “caramel” and an unknown neutral aroma. Frontenac gris wines changed from an unknown neutral aroma to “fruity” and “rose”. Results from the lay audiences’ flavor and aroma descriptors also indicate a shift with harvest date and associated °Brix. To date, this is the first report of wine aromas from Brianna and Frontenac gris by GC-MS-O. Findings from this research support the hypothesis that aroma profiles of Brianna and Frontenac gris wines can be influenced by harvesting the grapes at different stages of ripening.
Overexpression of Rice Rab7 Gene Improves Drought and Heat Tolerance and Increases Grain Yield in Rice (Oryza sativa L.)
Authors: El-Esawi Mohamed A. , Alayafi Aisha A.
Published: January 2019

Rab family proteins play a crucial role in plant developmental processes and tolerance to environmental stresses. The current study investigated whether rice Rab7 (OsRab7) overexpression could improve rice tolerance to drought and heat stress conditions. The OsRab7 gene was cloned and transformed into rice plants. The survival rate, relative water content, chlorophyll content, gas-exchange characteristics, soluble protein content, soluble sugar content, proline content, and activities of antioxidant enzymes (CAT, SOD, APX, POD) of the transgenic rice lines were significantly higher than that of the wild-type. In contrast, the levels of hydrogen peroxide, electrolyte leakage, and malondialdehyde of the transgenic lines were significantly reduced when compared to wild-type. Furthermore, the expression of four genes encoding reactive oxygen species (ROS)-scavenging enzymes (OsCATA, OsCATB, OsAPX2, OsSOD-Cu/Zn) and eight genes conferring abiotic stress tolerance (OsLEA3, OsRD29A, OsSNAC1, OsSNAC2, OsDREB2A, OsDREB2B, OsRAB16A, OsRAB16C) was significantly up-regulated in the transformed rice lines as compared to their expression in wild-type. OsRab7 overexpression also increased grain yield in rice. Taken together, the current study indicates that the OsRab7 gene improves grain yield and enhances drought and heat tolerance in transgenic rice by modulating osmolytes, antioxidants and abiotic stress-responsive genes expression. Therefore, OsRab7 gene could be exploited as a promising candidate for improving rice grain yield and stress tolerance.
Intrusion of Saline Water into a Coastal Aquifer Containing Palaeogroundwater in the Viimsi Peninsula in Estonia
Authors: Raidla Valle , Pärn Joonas , Aeschbach Werner , Czuppon György , Ivask Jüri , Kiisk Madis , Mokrik Robert , Samalavičius Vytautas , Suursoo Siiri , Tarros Siim , Weissbach Therese
Published: January 2019

The Viimsi peninsula is located north-east of Tallinn, capital of Estonia. The Cambrian-Vendian (Cm-V) aquifer system is a sole source of drinking water in the area. Historically, the groundwater exploitation has led to freshening of groundwater in the peninsula, but in recent years an increase in chloride concentrations and enrichment in δ18O values has been detected, but in recent years hydrochemical parameters indicate an increasing influence of a saline water source. The exact origin of this saline water has remained unclear. The aim of the current study is to elucidate whether the increase in Cl− concentrations is related to seawater intrusion or to the infiltration of saline water from the underlying crystalline basement. To identify the source of salinity, chemical composition of the groundwater and the isotope tracers (e.g., δ18O and radium isotopes) were studied in the Viimsi peninsula in the period from 1987 to 2018. Our results show that chemical composition of Cm-V groundwater in the peninsula is clearly controlled by three-component mixing between glacial palaeogroundwater, saline water from the underling crystalline basement and modern meteoric water. The concentrations of Ra are also significantly affected by the mixing, but the spatial variation of radium isotopes (226Ra and 228Ra) suggests the widespread occurrence of the U in the surrounding sedimentary sequence. Our hypothesis is that, in addition to U originating from the crystalline basement, some U could be associated with secondary U deposits in sedimentary rocks. The formation of these secondary U deposits could be related to glacial meltwater intrusion in the Pleistocene. Although the results suggest that the infiltration of saline groundwater from the underlying crystalline basement as the main source of salinity in the study area, the risk of seawater intrusion in the future cannot be ruled out. It needs to be highlighted that the present groundwater monitoring networks may not be precise enough to detect the potential seawater intrusion and subsequent changes in water quality of the Cm-V aquifer system in the Viimsi peninsula.
Portugal in the European Network of Marine Science Heritage and Outreach (19th–20th Centuries)
Authors: Amorim Inês , Pinto Bruno
Published: January 2019

The gradual consciousness of the scientific and economic riches of marine life is rooted in the legacy of some pillars of scientific production and dissemination in institutions such as natural history museums, aquariums, and maritime stations. Nowadays, one of the biggest issues of these scientific collections of species (marine or others) is their contextual interpretation which demands its original collection point, collectors, and original aims. The current research focuses on the origin of collections of marine specimens in Portugal as well as their historical evolution. In this particular approach, we assess the connection of the Portuguese natural history museums, universities and aquariums to similar European institutions since the mid-19th century, crossing primary sources from different archives. It was possible to reconstruct connections with the Zoological Station of the bay of Naples (Italy), the Maritime Museum of Monaco, and Aquariums of Monaco, France, and England. We identify both informers and the circulation of zoological specimens that underpin Museums and Aquariums collections that are today important scientific heritage repositories for a larger understanding of marine biodiversity and its threats, and core places of aesthetic contemplation and of philosophical discussion about the evolution of scientific knowledge.
Living the 14/14 Schedule: Qualitative Analysis of the Challenges and Coping Strategies among Families of Offshore Wind Workers
Authors: Mette Janika , Robelski Swantje , Kirchhöfer Maria , Harth Volker , Mache Stefanie
Published: January 2019

Offshore wind workers in Germany usually spend 14 days offshore, alternating with 14 days of spare time at home. The offshore lifestyle may considerably affect offshore workers’ partners and families. However, there is a lack of evidence regarding the psychosocial adaptation among offshore wind couples living the 14/14 schedule. The present study intended to offer a contemporary view on the topic from the perspective of the women of offshore workers. Our aim was (1) to examine the perceived features of living the 14/14 schedule, (2) explore women’s coping strategies, and (3) investigate their views on the reconciliation of offshore work and partnership/family life. The women reported differentiated views on the benefits and costs associated with their living situation, and stated various coping strategies that facilitated psychosocial adaptation. Despite some burdens, overall, most of the women seemed to have adapted relatively favourably to their lifestyle. This was particularly eased by recent sociological and technological advances, e.g., improved communication technologies.
Effects of Cardiorespiratory Exercise on Cognition in Older Women Exposed to Air Pollution
Authors: Molina-Sotomayor Edgardo , González Orb Marcelo , Pradas de la Fuente Francisco , Carozzi Figueroa Giovanni , Sánchez-Oliver Antonio Jesús , González-Jurado José Antonio
Published: January 2019

The aim was to analyze the effects of cardiorespiratory exercise and air pollution on cognition and cardiovascular markers in four groups of older women: the active/clean air group (AC), the active/polluted air group (AP), the sedentary/clean air group (SC), and the sedentary/polluted air group (SP). Active groups performed a training task based on progressive walking. Prior to and after the experiment, the following parameters were assessed: cognition, by Mini Mental State Examination (MMSE); maximum oxygen uptake (VO2max), estimated by the Six-Minute Walk Test (6mWT); heart rate (HR); and oxygen saturation (SpO2). There were significant differences (p < 0.05) between the AC and the SP in all the MMSE dimensions except “Registration”, and in all the physiological variables (VO2max, SpO2, HR). Aerobic exercise may be a protective factor against the effects that pollution have on cognition and on the mechanisms of oxygen transport.
Study on the Filtration Performance of the Baghouse Filters for Ultra-Low Emission as a Function of Filter Pore Size and Fiber Diameter
Authors: Liu Xingcheng , Shen Henggen , Nie Xueli
Published: January 2019

The main objective of this study was to determine the effect of filter pore size and fiber diameter on the performance of the baghouse filters for ultra-low emission. In this study, three kinds of conventional polyester filter (depth filtration media) and two kinds of polytetrafluoroethylene membrane-coated polyester filter (surface filtration media), having various filter pore sizes and fiber diameters, were tested to determine the performance of static and dynamic filtration. In order to determine the static filtration performance, the filtration resistance and the filtration efficiency of the clean filter media were measured by the arrestance method. The dynamic filtration performance experiments were conducted to determine the dynamic resistances, dust depositions, and dynamic filtration efficiencies of the dust-containing filter media under the condition of dust airflow filtration through a pulse-cleaning cycle. In the dynamic filtration performance experiments, the size of 50% test dust was less than 2.5 μm, and the mass mean aerodynamic diameter of the dust was 1.5 μm. The filtration velocity was 2 m∙min−1, and the dust concentration was 18.4 g∙m−3. The static filtration performance experiments showed that the filter pore size greatly affected the filtration resistance and the filtration efficiency of the fabric structure of the surface filtration media. In the depth filtration media, the filtration efficiency and the filtration resistance of the fabric structure were improved when the filter pore size and the fiber diameter were smaller in magnitude. For all the five filter media, smaller the pore size of the filter media, greater was the filtration precision (for fine particles, such as PM2.5) of the fabric structure. In the dynamic filtration performance experiments, the filter pore size and the fiber diameter of the depth filtration media affected the dynamic filtration resistance and the dynamic filtration efficiency of the depth filtration media by affecting the deposition rate of dust in the depth filtration media; however, the filter pore size of the surface filtration media affected the blocking rate of dust in the membrane micropores, thus influencing the dynamic filtration resistance and the dynamic filtration efficiency of the surface filtration media.
Acoustic Comfort in Virtual Inner Yards with Various Building Facades
Authors: Taghipour Armin , Sievers Tessa , Eggenschwiler Kurt
Published: January 2019

Housing complex residents in urban areas are not only confronted with typical noise sources, but also everyday life sounds, e.g., in the yards. Therefore, they might benefit from the increasing interest in soundscape design and acoustic comfort improvement. Three laboratory experiments (with repeated-measures complete block designs) are reported here, in which effects of several variables on short-term acoustic comfort were investigated. A virtual reference inner yard in the ODEON software environment was systematically modified by absorbers on building facades, whereby single-channel recordings were spatialized for a 2D playback in laboratory. Facade absorption was found, generally, to increase acoustic comfort. Too much absorption, however, was not found to be helpful. In the absence of any absorbers on the facade, absorbing balcony ceilings tended to improve acoustic comfort, however, non-significantly. Pleasant and unpleasant sounds were associated with comfort and discomfort, accordingly. This should encourage architects and acousticians to create comfortable inner yard sound environments, where pleasant and unpleasant sound occurrence probabilities are designed to be high and low, respectively. Furthermore, significant differences were observed between acoustic comfort at distinct observer positions, which could be exploited when designing inner yards.
Religious Coping, Religiosity, Depression and Anxiety among Medical Students in a Multi-Religious Setting
Authors: Francis Benedict , Gill Jesjeet Singh , Yit Han Ng , Petrus Chiara Francine , Azhar Fatin Liyana , Ahmad Sabki Zuraida , Said Mas Ayu , Ong Hui Koh , Chong Guan Ng , Sulaiman Ahmad Hatim
Published: January 2019

Medical students are vulnerable to depression and anxiety due to the nature of their academic life. This study aimed to determine the prevalence of depressive and anxiety symptoms among medical students and the association between religious coping, religiosity and socio-demographic factors with anxiety and depressive symptoms. A cross sectional design was used for this study. Scales used were the Malay version of the Duke Religious Index (DUREL-M), the Malay version of the Brief Religious Coping Scale (Brief RCOPE) and the Malay version Hospital and Anxiety Depression Scale (HADS-M). 622 students participated in this study. They scored moderately on the organized (mean: 3.51) and non-organized religious (mean: 3.85) subscales of the DUREL, but had high intrinsic religiosity (mean: 12.18). The prevalence of anxiety and depressive symptoms were 4.7% and 17.4% respectively, which is lower than local as well as international data. Islam, negative religious coping and the presence of depressive symptoms were significantly associated with anxiety symptoms. Only the presence of anxiety symptoms was significantly associated with depressive symptoms. Negative religious coping, rather than positive religious coping, has significant association with depressive and anxiety symptoms. Redirecting focus towards negative religious coping is imperative to boost mental health outcomes among medical students.
Potential Effects of Lung Function Reduction on Health-Related Quality of Life
Authors: Wen Yuhan , Wang Dongming , Zhou Min , Zhou Yun , Guo Yanjun , Chen Weihong
Published: January 2019

Health-related quality of life (HRQOL) was reported to reflect overall quality of life and individual perceptions related to health. Decreased lung function is associated with reduced ventilation and oxygen intake and reported to affect body functions. However, the effect of lung function reduction on HRQOL is still unclear. A total of 8398 retired workers from Dongfeng-Tongji Cohort Study were included in this cross section study. Lung function was measured using an electronic spirometer. HRQOL was evaluated through a questionnaire designed according to the WHOQOL-BREF. The mean of the HRQOL scores of its four domains (physical health, psychological state, social relationships and environment) is the total HRQOL score. A general linear model was used to analyse the association between lung function and HRQOL. In the continuous analysis by the general linear model, FVC was associated with the total HRQOL, physical health domain and social relationships domain scores. In the categorical analysis, there was a linear trend between FVC and the total HRQOL and physical health scores. We also found a similar relationship between FEV1 and HRQOL scores. Further analysis suggested that elevated lung function could improve the scores of pain and discomfort facet and independence facet of physical health domain. The lung function was significantly positively associated with HRQOL in middle-aged and older Chinese.
Semi-Automatic Versus Manual Mapping of Cold-Water Coral Carbonate Mounds Located Offshore Norway
Authors: Jarna Alexandra , Baeten Nicole J. , Elvenes Sigrid , Bellec Valérie K. , Thorsnes Terje , Diesing Markus
Published: January 2019

Cold-water coral reefs are hotspots of biological diversity and play an important role as carbonate factories in the global carbon cycle. Reef-building corals can be found in cold oceanic waters around the world. Detailed knowledge on the spatial location and distribution of coral reefs is of importance for spatial management, conservation and science. Carbonate mounds (reefs) are readily identifiable in high-resolution multibeam echosounder data but systematic mapping programs have relied mostly on visual interpretation and manual digitizing so far. Developing more automated methods will help to reduce the time spent on this laborious task and will additionally lead to more objective and reproducible results. In this paper, we present an attempt at testing whether rule-based classification can replace manual mapping when mapping cold-water coral carbonate mounds. To that end, we have estimated and compared the accuracies of manual mapping, pixel-based terrain analysis and object-based image analysis. To verify the mapping results, we created a reference dataset of presence/absence points agreed upon by three mapping experts. There were no statistically significant differences in the overall accuracies of the maps produced by the three approaches. We conclude that semi-automated rule-based methods might be a viable option for mapping carbonate mounds with high spatial detail over large areas.
Extracellular Vesicles from Fresh and Dried Plants—Simultaneous Purification and Visualization Using Gel Electrophoresis
Authors: Woith Eric , Melzig Matthias F.
Published: January 2019

Although animal-derived extracellular vesicles (EVs) are moving increasingly into scientific focus, EVs from other kingdoms remain underestimated and our knowledge of them is still expandable, probably due to the lack of an easy and broadly executable isolation, purification and visualization method. Using differential centrifugation with subsequent agarose gel electrophoresis, we were able to simplify the terms of EV isolation. EVs from Nicotiana tabacum L., Vinca minor L., and Viscum album L. were purified, even though they did not migrate into the gel matrix. If 3,3- Dihexyloxacarbocyanine iodide (DiOC 6 ) is added to the specimen in excess, membranous components can already be detected by eye, or with higher sensitivity, using a UV transilluminator. The sample preparation can be adjusted to the EV species of interest. Moreover, EVs are separated from small charged contaminants and dye excess, because these impurities can pass the gel matrix, while EVs themselves are retained in the pocket. Significantly, we isolated EVs from dried plant material, which is—to our knowledge—the first proof that EVs are stable enough to overcome the drying process of plant material.
Additives for Efficient Biodegradable Antifouling Paints
Authors: Faÿ Fabienne , Gouessan Maëlle , Linossier Isabelle , Réhel Karine
Published: January 2019

The evolution of regulations concerning biocidal products aims to increase protection of the environment (e.g., EU Regulation No 528/2012) and requires the development of new non-toxic anti-fouling (AF) systems. The development of these formulations implies the use of ingredients (polymers, active substances, additives) that are devoid of toxicity towards marine environments. In this context, the use of erodable antifouling paints based on biodegradable polymer and authorized biocides responds to this problem. However, the efficiency of paints could be improved by the use of specific additives. For this purpose, three additives acting as surface modifiers were studied (Tween 80, Span 85 and PEG-silane). Their effects on parameters involved in antifouling efficiency as hydrophobicity, hydration and copper release were studied. Results showed that the addition of 3% of additives modulated hydrophobicity and hydration without an increase of copper release and significantly reduced microfouling development. Efficient paints based on biodegradable polymer and with no organic biocide could be obtained by mixing copper thiocyanate and additives.
Comprehensive Analysis of Differentially Expressed Unigenes under NaCl Stress in Flax (Linum usitatissimum L.) Using RNA-Seq
Authors: Wu Jianzhong , Zhao Qian , Wu Guangwen , Yuan Hongmei , Ma Yanhua , Lin Hong , Pan Liyan , Li Suiyan , Sun Dequan
Published: January 2019

Flax (Linum usitatissimum L.) is an important industrial crop that is often cultivated on marginal lands, where salt stress negatively affects yield and quality. High-throughput RNA sequencing (RNA-seq) using the powerful Illumina platform was employed for transcript analysis and gene discovery to reveal flax response mechanisms to salt stress. After cDNA libraries were constructed from flax exposed to water (negative control) or salt (100 mM NaCl) for 12 h, 24 h or 48 h, transcription expression profiles and cDNA sequences representing expressed mRNA were obtained. A total of 431,808,502 clean reads were assembled to form 75,961 unigenes. After ruling out short-length and low-quality sequences, 33,774 differentially expressed unigenes (DEUs) were identified between salt-stressed and unstressed control (C) flax. Of these DEUs, 3669, 8882 and 21,223 unigenes were obtained from flax exposed to salt for 12 h (N1), 24 h (N2) and 48 h (N4), respectively. Gene function classification and pathway assignments of 2842 DEUs were obtained by comparing unigene sequences to information within public data repositories. qRT-PCR of selected DEUs was used to validate flax cDNA libraries generated for various durations of salt exposure. Based on transcriptome sequences, 1777 EST-SSRs were identified of which trinucleotide and dinucleotide repeat microsatellite motifs were most abundant. The flax DEUs and EST-SSRs identified here will serve as a powerful resource to better understand flax response mechanisms to salt exposure for development of more salt-tolerant varieties of flax.
Targeting the Hepatocyte Growth Factor and c-Met Signaling Axis in Bone Metastases
Authors: Whang Young Mi , Jung Seung Pil , Kim Meyoung-Kon , Chang In Ho , Park Serk In
Published: January 2019

Bone metastasis is the terminal stage disease of prostate, breast, renal, and lung cancers, and currently no therapeutic approach effectively cures or prevents its progression to bone metastasis. One of the hurdles to the development of new drugs for bone metastasis is the complexity and heterogeneity of the cellular components in the metastatic bone microenvironment. For example, bone cells, including osteoblasts, osteoclasts, and osteocytes, and the bone marrow cells of diverse hematopoietic lineages interact with each other via numerous cytokines and receptors. c-Met tyrosine kinase receptor and its sole ligand hepatocyte growth factor (HGF) are enriched in the bone microenvironment, and their expression correlates with the progression of bone metastasis. However, no drugs or antibodies targeting the c-Met/HGF signaling axis are currently available in bone metastatic patients. This significant discrepancy should be overcome by further investigation of the roles and regulation of c-Met and HGF in the metastatic bone microenvironment. This review paper summarizes the key findings of c-Met and HGF in the development of novel therapeutic approaches for bone metastasis.
Adverse Outcomes after Major Surgeries in Patients with Diabetes: A Multicenter Matched Study
Authors: Lin Chao-Shun , Chang Chuen-Chau , Lee Yuan-Wen , Liu Chih-Chung , Yeh Chun-Chieh , Chang Yi-Cheng , Chuang Ming-Tsang , Chang Tzu-Hao , Chen Ta-Liang , Liao Chien-Chang
Published: January 2019

The impact of diabetes on perioperative outcomes remains incompletely understood. Our purpose is to evaluate post-operative complications and mortality in patients with diabetes. Using the institutional and clinical databases of three university hospitals from 2009–2015, we conducted a matched study of 16,539 diabetes patients, aged >20 years, who underwent major surgery. Using a propensity score matching procedure, 16,539 surgical patients without diabetes who underwent surgery were also selected. Logistic regressions were used to calculate the odds ratios (ORs) with 95% confidence intervals (CIs) for post-operative complications and in-hospital mortality associated with diabetes. Patients with diabetes had a higher risk of postoperative septicemia (OR 1.33, 95% CI 1.01–1.74), necrotizing fasciitis (OR 3.98, 95% CI 1.12–14.2), cellulitis (OR 2.10, 95% CI 1.46–3.03), acute pyelonephritis (OR 1.86, 95% CI 1.01–3.41), infectious arthritis (OR 3.89, 95% CI 1.19–12.7), and in-hospital mortality (OR 1.51, 95% CI 1.07–2.13) compared to people without diabetes. Previous admission for diabetes (OR 2.33, 95% CI 1.85–2.93), HbA1c >8% (OR 1.96, 95% CI 1.64–2.33) and fasting glucose >180 mg/dL (OR 1.90, 95% CI 1.68–2.16) were predictors for post-operative adverse events. Diabetes patients who underwent surgery had higher risks of infectious complications and in-hospital mortality compared with patients without diabetes who underwent similar major surgeries.
It’s about Time: Effects of Physical Exertion on Duration Estimates
Authors: Brewer Britton W. , Schwartz Lawrence O. , Cornelius Allen E. , Van Raalte Judy L. , Urbina Edmundo L. , Stubbs John S.
Published: January 2019

Background: Task duration is a fundamental aspect of exercise, but little is known about how completed bouts of physical activity are perceived. Consequently, the purpose of the five experiments conducted for this investigation was to examine the effects of engaging in physical tasks on retrospective duration estimates with college student participants. Methods: Across the five experiments, participants were 113 college students (82 women, 31 men). In Experiments 1 and 2, participants provided duration estimates of a period spent engaging in physical activity or rest. In Experiments 3, 4, and 5, participants provided duration estimates of periods spent engaged in physical tasks of high intensity and low intensity. Results: In Experiments 1, 2, and 3, participants engaged in physical activity tended to perceive durations as shorter than participants at rest. When completing less familiar tasks (Experiments 4 and 5), however, participants recalled a high intensity bout of physical activity as lasting longer than a low intensity bout of physical activity of comparable duration. Cohen’s d values for physical activity effects on duration estimates ranged from 0.40 to 1.60. Conclusion: The findings, which partially support a contextual-change interpretation, suggest that factors, such as perceived exertion and task familiarity, affect retrospective duration estimates.
Acknowledgement to Reviewers of Journal of Low Power Electronics and Applications in 2018
Authors:   Journal of Low Power Electronics and Applications Editorial Office
Published: January 2019

Rigorous peer-review is the corner-stone of high-quality academic publishing [...]
Microstructure and Mechanical Properties of 34CrNiMo6 Steel Repaired by Friction Stir Processing
Authors: Wu Zhongwen , Huang Chunping , Liu Fencheng , Xia Chun , Ke Liming
Published: January 2019

Repairing damaged parts using proper repairing methods has become an important means to reduce manufacturing and operational costs and prolong the service life of 34CrNiMo6 steel structures. In the conventional fusion repairing method, welding wire and powder are often used as filling materials. Filling materials are often expensive or difficult to find. Some metallurgical issues (such as solidification crack, higher distortion) were also found with these methods. At the same time, most of the equipment that requires welding wire and powder is expensive. In this study, a new method based on friction stir processing (FSP) was successfully employed to repair 34CrNiMo6 steel, using a block as filling material. Filling blocks are much cheaper than conventional fusion repair consumables. As a result of solid-state repair, this method can also avoid the metallurgical issues of fusion repair. The microstructure and mechanical properties of the repaired samples were investigated using OM (Optical Microscope), SEM, EDS (Energy Dispersive Spectroscopy), XRD, and a Vickers hardness electronic universal tensile tester. The results showed that 34CrNiMo6 steel was successfully repaired by this method, with no defect. Tensile tests showed that the maximum ultimate strength (UTS) was 900 MPa and could reach 91.8% of that of the substrate. The fracture mode of the tensile samples was ductile/brittle mixed fracture. Hence, the repairing method based on FSP appears to be a promising method for repairing castings.
Probabilistic Conversion of the Compressive Strength of Cubes to Cylinders of Natural and Recycled Aggregate Concrete Specimens
Authors: Pacheco João Nuno , de Brito Jorge , Chastre Carlos , Evangelista Luís
Published: January 2019

This paper investigates the effect of recycled coarse aggregate incorporation on the relationship between 150 mm cubic and Փ 150 mm cylindrical compressive strength (the reference strength of standards) by comparing data from recycled and natural aggregate concrete compositions in which both cubes and cylinders were tested. A conversion factor from cubic to cylindrical strength is proposed in two versions: A deterministic and a probabilistic one. Such factor has not been studied before and researchers have been converting cubic data as if natural aggregate concrete were tested. The probabilistic factor is intended for reliability analyses on the structural behaviour of recycled aggregate concrete using data from laboratory cube tests. It was found that the incorporation of recycled coarse aggregates sourced from concrete waste significantly decreases the expected value of the factor but the factor’s scatter is relatively unaffected.
Discrete Element Modeling of Intermetallic Matrix Composite Manufacturing by Powder Metallurgy
Authors: Nosewicz Szymon , Rojek Jerzy , Chmielewski Marcin , Pietrzak Katarzyna
Published: January 2019

This paper presents a numerical and experimental analysis of manufacturing of intermetallic ceramic composites by powder metallurgy techniques. The scope of the paper includes the formulation and development of an original numerical model of powder metallurgy of two-phase material within the framework of the discrete element method, simulations of powder metallurgy processes for different combinations of process parameters, and a verification of the numerical model based on own experimental results. Intermetallic-based composite NiAl–Al 2 O 3 has been selected as representative material for experimental and numerical studies in this investigation. Special emphasis was given to the interactions between the intermetallic and ceramic particles by formulating the special model for adhesive contact bond. In order to properly represent a real microstructure of a two-phase sintered body, a discrete element specimen was generated using a special algorithm. Numerical validation showed the correct numerical representation of a sintered two-phase composite specimen. Finally, micromechanical analysis was performed to explain the macroscopic behavior of the sintered sample. The evolution of the coordination number, a number of equilibrium contacts, and the distribution of the cohesive neck size with respect to time are presented.
Effect of Zn/Mg Ratios on Microstructure and Stress Corrosion Cracking of 7005 Alloy
Authors: Wang Shuai , Luo Binghui , Bai Zhenhai , He Chuan , Tan Sizhi , Jiang Gen
Published: January 2019

The effects of different Zn/Mg ratios on the microstructure, mechanical properties and resistance of stress corrosion cracking of peak-aged 7005 aluminum alloy were investigated. It was found that the Zn/Mg ratio played a very important role in controlling the aging time, the electrical conductivity of the hardness peak point and the resistance of stress corrosion cracking of the alloy. With the increase of Zn/Mg ratio (wt. %), the time taken by the alloy to achieve the peak hardness value gradually increases aging at 120 °C. When the Zn/Mg ratio is in the range from 2.27% to 2.62%, the precipitate phase of the alloy after peak-aged is mainly dominated by smaller disc-like η’ phase and GP I (Guinier Preston) zones, the grain boundary precipitates are slender and continuous and the PFZ (precipitate free zones) is narrow. However when this value is in the range from 3.01% to 4.08%, precipitation phase in matrix of the alloy is mainly composed of short-rod η′ phase and GP II zones, the precipitation phases within the grain boundary are large and distribute intermittently and the PFZ is narrower. The results of SSRT (slow strain rate tests) show that when Zn/Mg ≥ 3.61, the 7005 aluminum alloy at peak-aged has good resistance of stress corrosion cracking in 3.5% NaCl + 0.5% H2O2 aqueous solution. However, when Zn/Mg ≤ 3.01, the strength of the alloy sharply decreases in 3.5% (wt. %) NaCl + 0.5% (wt. %) H2O2 aqueous solution.
The Nature-Inspired Metaheuristic Method for Predicting the Creep Strain of Green Concrete Containing Ground Granulated Blast Furnace Slag
Authors: Sadowski Łukasz , Nikoo Mehdi , Shariq Mohd , Joker Ebrahim , Czarnecki Sławomir
Published: January 2019

The aim of this study was to develop a nature-inspired metaheuristic method to predict the creep strain of green concrete containing ground granulated blast furnace slag (GGBFS) using an artificial neural network (ANN)model. The firefly algorithm (FA) was used to optimize the weights in the ANN. For this purpose, the cement content, GGBFS content, water-to-binder ratio, fine aggregate content, coarse aggregate content, slump, the compaction factor of concrete and the age after loading were used as the input parameters, and in turn, the creep strain (εcr) of the GGBFS concrete was considered as the output parameters. To evaluate the accuracy of the FA-ANN model, it was compared with the well-known genetic algorithm (GA), imperialist competitive algorithm (ICA) and particle swarm optimization (PSO). Results indicated that the ANNs model, in which the weights were optimized by the FA, were more capable, flexible and precise than other optimization algorithms in predicting the εcr of GGBFS concrete.
Acknowledgement to Reviewers of MCA in 2018
Authors:   MCA Editorial Office
Published: January 2019

Rigorous peer-review is the corner-stone of high-quality academic publishing [...]
Kinetic Studies on Gas-Based Reduction of Vanadium Titano-Magnetite Pellet
Authors: Chen Junwei , Chen Weibin , Mi Liang , Jiao Yang , Wang Xidong
Published: January 2019

Vanadium titano-magnetite (VTM) is a significant resource in China—analysis shows that China possesses approximately 10 billion tons of VTM. In this study, we characterize VTM’s isothermal reduction mechanisms in the mixture of H2, CO, and N2 where the variables considered include reduction time, reduction temperature, gas composition, and pellet size. The kinetics of the reduction process were studied following a shrinking core model. The results indicate that the reduction degree of oxidized VTM pellets increases with increases of reduction time and reduction temperature but decreases with increasing pellet size. Moreover, we found that an increase of H2/(H2 + CO) ratio induced an increase of the reduction degree. We discuss the transformation of main Ti-bearing mineral phases, and we consider the most probable reaction mechanism. For the entire reduction process, the kinetic results confirm the existence of an early and later stages that are controlled by interface chemical reaction and diffusion, respectively. Furthermore, the results show that the diffusion-control step can be observably shortened via decreased pellet size because a thinner product layer is formed during the reduction process. Our study thus provides a valuable technical basis for industrial applications of VTM.
Titanocene Selenide Sulfides Revisited: Formation, Stabilities, and NMR Spectroscopic Properties
Authors: Laasonen Heli , Ikäheimonen Johanna , Suomela Mikko , Rautiainen J. Mikko , Laitinen Risto S.
Published: January 2019

[TiCp2S5] (phase A), [TiCp2Se5] (phase F), and five solid solutions of mixed titanocene selenide sulfides [TiCp2SexS5−x] (Cp = C5H5−) with the initial Se:S ranging from 1:4 to 4:1 (phases B–E) were prepared by reduction of elemental sulfur or selenium or their mixtures by lithium triethylhydridoborate in thf followed by the treatment with titanocene dichloride [TiCp2Cl2]. Their 77Se and 13C NMR spectra were recorded from the CS2 solution. The definite assignment of the 77Se NMR spectra was based on the PBE0/def2-TZVPP calculations of the 77Se chemical shifts and is supported by 13C NMR spectra of the samples. The following complexes in varying ratios were identified in the CS2 solutions of the phases B–E: [TiCp2Se5] (51), [TiCp2Se4S] (41), [TiCp2Se3S2] (31), [TiCp2SSe3S] (36), [TiCp2SSe2S2] (25), [TiCp2SSeS3] (12), and [TiCp2S5] (01). The disorder scheme in the chalcogen atom positions of the phases B–E observed upon crystal structure determinations is consistent with the spectral assignment. The enthalpies of formation calculated for all twenty [TiCp2SexS5−x] (x = 0–5) at DLPNO-CCSD(T)/CBS level including corrections for core-valence correlation and scalar relativistic, as well as spin-orbit coupling contributions indicated that within a given chemical composition, the isomers of most favourable enthalpy of formation were those, which were observed by 77Se and 13C NMR spectroscopy.
TiO2 Photocatalysis for Transfer Hydrogenation
Authors: Ma Dongge , Zhai Shan , Wang Yi , Liu Anan , Chen Chuncheng
Published: January 2019

Catalytic transfer hydrogenation reactions, based on hydrogen sources other than gaseous H2, are important processes that are preferential in both laboratories and factories. However, harsh conditions, such as high temperature, are usually required for most transition-metal catalytic and organocatalytic systems. Moreover, non-volatile hydrogen donors such as dihydropyridinedicarboxylate and formic acid are often required in these processes which increase the difficulty in separating products and lowered the whole atom economy. Recently, TiO2 photocatalysis provides mild and facile access for transfer hydrogenation of C=C, C=O, N=O and C-X bonds by using volatile alcohols and amines as hydrogen sources. Upon light excitation, TiO2 photo-induced holes have the ability to oxidatively take two hydrogen atoms off alcohols and amines under room temperature. Simultaneously, photo-induced conduction band electrons would combine with these two hydrogen atoms and smoothly hydrogenate multiple bonds and/or C-X bonds. It is heartening that practices and principles in the transfer hydrogenations of substrates containing C=C, C=O, N=O and C-X bond based on TiO2 photocatalysis have overcome a lot of the traditional thermocatalysis’ limitations and flaws which usually originate from high temperature operations. In this review, we will introduce the recent paragon examples of TiO2 photocatalytic transfer hydrogenations used in (1) C=C and C≡C (2) C=O and C=N (3) N=O substrates and in-depth discuss basic principle, status, challenges and future directions of transfer hydrogenation mediated by TiO2 photocatalysis.
Umami as an ‘Alimentary’ Taste. A New Perspective on Taste Classification
Authors: Hartley Isabella E , Liem Djin Gie , Keast Russell
Published: January 2019

Applied taste research is increasingly focusing on the relationship with diet and health, and understanding the role the sense of taste plays in encouraging or discouraging consumption. The concept of basic tastes dates as far back 3000 years, where perception dominated classification with sweet, sour, salty, and bitter consistently featuring on basic taste lists throughout history. Advances in molecular biology and the recent discovery of taste receptors and ligands has increased the basic taste list to include umami and fat taste. There is potential for a plethora of other new basic tastes pending the discovery of taste receptors and ligands. Due to the possibility for an ever-growing list of basic tastes it is pertinent to critically evaluate whether new tastes, including umami, are suitably positioned with the four classic basic tastes (sweet, sour, salty, and bitter). The review critically examines the evidence that umami, and by inference other new tastes, fulfils the criteria for a basic taste, and proposes a subclass named ‘alimentary’ for tastes not meeting basic criteria.