bluuebunny/crossref_metadata_2025 huggingface dataset:
ANGIOGRAPHY AND REGIONAL CHEMOTHERAPY IN TREATMENT OF BREAST CANCER PATIENTS
Authors: Suvorova Yuliya , Buynyakova A. , Milkevich I. , Kuznetsova Yu. , Chagunava O.
Published: November 2020

The aim of the study was to evaluate the safety of regional chemotherapy and to find the most optimal technique for regional administration of chemotherapy in the arteries of the breast taking into account the localization of the tumor. Diagnostic angiography and regional chemotherapy were performed in 10 patients with breast cancer. Cancer of the right breast was diagnosed in 6 women, left - in 3 women, tumors of both breasts were detected in 1 patient. For regional administration cyclophosphamide (7) and paclitaxel (3) were used. The estimations of the doses were carried out according to a standard procedure. Chemotherapy medicines were infused in the arteries of the breast under fluoroscopic control, slowlY., for 30 min. In the most patients (6 of 10 patients) the angiographic pattern was nonspecific. At large tumor sizes pathological vessels and areas of hypervascularization were identified (4). The catheterization of the internal thoracic artery on the side of the lesion for regional chemotherapy was performed in 9 out of 10 cases. With tumors of large sizes and lesions of lymph nodes chemotherapy medicines were additionally injected into the axillary artery (2 of 10 patients). The catheterization of the external thoracic artery was performed when the tumor was localized in the outer parts of the breast (1). Complications of regional chemotherapy and severe systemic toxicity were not observed. Diagnostic angiography allowed assessing the vascular anatomy of the thoracic arteries, the sources of blood supply of breast tumor and most optimally planning further therapeutic endovascular intervention. Thus, regional chemotherapy is a safe method of treatment for breast cancer that does not have severe systemic toxicity.
AGE FEATURES OF MOLECULAR-BIOLOGICAL SUBTYPES OF BREAST CANCER IN THE REPUBLIC OF UZBEKISTAN
Authors: Miryusupova Gulya , Khakimov G. , Shayusupov N.
Published: November 2020

According to the results of breast cancer data in the Republic of Uzbekistan in addition to the increase in morbidity and mortality from breast cancer among women the presence of age specific features among indigenous women in the direction of “rejuvenating” of the disease with all molecular-biological (phenotypic) subtypes of breast cancer were marked. Within the framework of age-related features the prevalence of the least favorable phenotypes of breast cancer was found among indigenous women: Her2/neu hyperexpressive and three times negative subtype of breast cancer. The data obtained made it possible to build a so-called population “portrait” of breast cancer on the territory of the Republic, which in turn would contribute to further improvement of cancer care for the female population of the country.
DIAGNOSIS AND RECONSTRUCTIVE MICROSURGERY IN CASE OF THE LYMPHATIC SYSTEM LESION OF THE UPPER LIMB AFTER MASTECTOMY
Authors: Ivashkov Vladimir , Sobolevskiy Vladimir , Yegorov Yuriy , Krokhina Olga
Published: November 2020

Purpose: To improve the results of treatment of secondary lymphatic edema in patients after complex treatment of breast cancer and to introduce a method of fluorescent lymphography to assess the stage of lymphedema.
Materials and methods: The analysis of the results of examination and treatment of female patients with secondary lymphatic edema of the upper limbs, which appeared after the complex treatment of breast cancer in 2012-2016 was performed. To estimate the prevalence and stage of lymphatic edema all patients underwent fluorescent lymphography with indocyanine green. Based on fluorescent lymphography for each patient treatment algorithm was individually substantiated. Of 40 patients with secondary lymphatic edema 20 (50%) patients underwent surgical and 20 (50%) conservative treatment. The results were divided into early (up to 6 months) and long-term results (6-12 months).
Results: In the early period after treatment (up to 6 months) the results of treatment in the surgical and conservative groups were comparable. Long-term results (6-12 months) were significantly higher in the group of patients after inguinal lymph node transplantation in combination with conservative methods than the isolated use of conservative methods.
Conclusion: The method of fluorescent lymphography with indocyanine green is modern and accurate for the diagnosis of lymphatic edema. It allows determining the stage and prevalence of lymphatic edema. It is an indispensable tool for visualization of lymph nodes in the allocation of the inguinal lymphatic flap and postoperative control of the functional activity of the transplanted lymph nodes. The combination of lymph node transplant with conservative therapy gives better results than the isolated use of conservative methods.
BP-C3 POLYPHENOLIC COMPOSITION INFLUENCE ON DYNAMICS OF 5-FLUOROURACIL INDUCED DAMAGE IN SMALL INTESTINE EPITHELIUM IN MICE
Authors: Gubareva Yekaterina , Panchenko Andrey , Fedoros Yelena , Maydin Mikhail
Published: November 2020

Chemotherapeutic drugs negatively influence on normal tissues with high proliferative activity such as intestinal epithelium. The damage of chemotherapy to healthy tissues significantly reduces oncological patients’ quality of life. Drugs based on polyphenolic natural compounds are a perspective mean of adjuvant therapy due to their antioxidant and antiinflammatory properties. In this study we have showed that a single intragastric administration of BPC3 polyphenolic composition 2 hours before 5-fluorouracil treatment alleviates small intestine damage in C57Bl/6 mice after 3.5, 24 or 72 hours. BPC3 effect manifested in reduced apoptosis rate, increased mitotic activity of the epithelium in the regenerative phase and protection of LGR5-positive jejunum stem cells against 5-fluorouracil induced damage.
CLINICAL EXPERIENCE OF USING BRACHYTHERAPY WITH HIGH DOSE RATE SOURCES FOR MONOTHERAPY IN PROSTATE CANCER PATIENTS
Authors: Novikov Sergey , Kanaev Sergey , Novikov Roman , Ilin N. , Gotovchikova M. , Girshovich M.
Published: November 2020

The aim of the study: to evaluate efficacy and toxicity of interstitial high-dose-rate prostate brachytherapy when it was used as monotherapy for low-, intermediate risk prostate cancer.
Material and methods: 198 primary patients with low-, intermediate risk prostate cancer that were treated from 1.07.2012 to 01.07.2017 were included in the study. Two fractions of 13Gy were used in 67 men, 3 fractions of 11.5Gy -in the remaining 131 patients. The reported end points were overall/cancer-specific survival, biochemical control rates according to Phoenix definition. Toxicity was scored according to the RTOG scale.
Results: The median follow-up time was 28.7 [19.3; 36.6] (10.9-58.9) months. The 3-year biochemical control (nadir+2) was reached in 94.1% cases. Late grade III genito-urinary toxicity was represented by urethral strictures in 1.6% of evaluated patients. Grade III rectal toxicity was not mentioned. IIEF score before treatment was below 16 in 28.8% patients and after brachytherapy - in 52.9% cases.
Conclusion: high dose rate brachytherapy can be effectively and safely used for monotherapy of patients with low-, intermediate risk prostate cancer.
IPILIMUMAB IN PATIENTS WITH DISSEMINATED MELANOMA: THE N.N. PETROV NATIONAL MEDICAL RESEARCH CENTER OF ONCOLOGY EXPANDED ACCESS PROGRAM EXPERIENCE
Authors: Anokhina Yekaterina , Rubinchik V. , Yaremenko Yekaterina , Teletaeva Gulfiya , Latipova Dilorom , Semenova Anna , Semiglazova Tatyana , Baldueva Irina , Protsenko Svetlana , Novik Aleksey , Oganesyan A.
Published: November 2020

Ipilimumab (IPI) provides a ten-year overall survival in almost 20 % of selected patients participated in several phase II-III trials. However, the expanded access program (EAP) looks more like routine practice than like clinical trials& This is why the results of such application could be different. Here we present the long-term follow-up data of single center EAP. Ninety-six patients with disseminated melanoma progressing after at least one lines of drug therapy were included at the N.N. Petrov National Medical Research Center of Oncology. Sixty-seven (70 %) patients had stage IV M1c, 35 patients (36 %) had elevated LDH before initiating IPI therapy. All patients received IPI 3 mg / kg IV every 3 weeks for a maximum of 4 cycles. Totally, 320 cycles (mean - 3.3 per patient) were conducted. Grade 3-4 immuno-mediated adverse events (imAE) observed in 18 (19 %) patients. Three patients died of adverse events, possibly associated with ongoing therapy. The median time to progression was 3 (95 % CI, 2.4 to 3.5) mo., the median overall survival was 13 (95 % CI, 8.3 to17.6) mo. Previous immunotherapy with dendritic cell vaccines decreased the risk of death by 48 % (Log-rank p = 0.049). The wild type BRAF status increased three-year overall survival from 29 to 68 % (p = 0.042). Our data confirms long-term safety and efficacy of IPI in patients with pretreated disseminated melanoma in the close to real practice setting.
COMPARATIVE FEATURES OF CARBOHYDRATE METABOLISM STATE, BODY WEIGHT AND ASSOCIATED HORMONAL FACTORS IN VARIOUS MOLECULAR-BIOLOGICAL TYPES OF ENDOMETRIAL CANCER
Authors: Bershteyn Lev , Poroshina Tatyana , Radzhabova Zamira , Kovalenko Irina , Ivantsov Aleksandr , Ievleva Aglaya , Berlev Igor
Published: November 2020

Aims: The tradition of dividing endometrial cancer (EC) into two types - which existed for many decades - has undergone significant changes over the past few years. The aim of this work was to collect data on important aspect of hormonal-metabolic status in patients having one of the four EC types which compose a modern molecular-biological classification of this tumor.
Materials and methods: The division of EC into types (234 tumors from patients predominantly of postmenopausal age) was based on the classification of this carcinoma, which includes cases with mutations in tumor tissue of DNA polymerase epsilon (POLE), signs of mismatch repair deficiency - microsatellite instability (MMR-D), expression of the multifunctional protein p53 and, finally, with the absence of these three features. In the studies of hormone-metabolic status, depending on the methodology, materials from a varying number of patients were involved.
Results and conclusions: It has been established that EC patients, carriers of the POLE mutations, are characterized by a lower body mass index (BMI), a decreased incidence of overt diabetes and a lower ratio of leptin/adiponectin in the serum. For patients with EC having signs of MMR-D, an increase in BMI and the most pronounced tendency to disturbances in carbohydrate metabolism were found, while for patients with increased expression of oncoprotein p53 were characteristic frequent detection of patients with low body weight (BMI <25.0) and a trend towards a decrease in the insulin resistance index. In conditionally “triply negative” type (not having three listed markers: POLE mutations, MMR-D signs and p53 hyperexpression), uterine body cancer patients revealed highest average BMI value and positive correlation of BMI with the level of leptinemia. The data obtained indicate the need for a selective approach to the prevention of different types of EC and for the study on the association of revealed type-specific features with the further course of the disease.
Temporal bisection is influenced by ensemble statistics of the stimulus set
Authors: Zhu Xiuna , Baykan Cemre , Müller Hermann J. , Shi Zhuanghua
Published: November 2020

Although humans are well capable of precise time measurement, their duration judgments are nevertheless susceptible to temporal context. Previous research on temporal bisection has shown that duration comparisons are influenced by both stimulus spacing and ensemble statistics. However, theories proposed to account for bisection performance lack a plausible justification of how the effects of stimulus spacing and ensemble statistics are actually combined in temporal judgments. To explain the various contextual effects in temporal bisection, we develop a unifiedensemble-distribution account(EDA), which assumes that the mean and variance of the duration set serve as a reference, rather than the short and long standards, in duration comparison. To validate this account, we conducted three experiments that varied the stimulus spacing (Experiment 1), the frequency of the probed durations (Experiment 2), and the variability of the probed durations (Experiment 3). The results revealed significant shifts of the bisection point in Experiments 1 and 2, and a change of the sensitivity of temporal judgments in Experiment 3—which were all well predicted by EDA. In fact, comparison of EDA to the extant prior accounts showed that using ensemble statistics can parsimoniously explain various stimulus set-related factors (e.g., spacing, frequency, variance) that influence temporal judgments.
Regional medical information systems in the field of healthcare: directions of development and legal problems
Authors:   Saint Petersburg University, Akulin I. M. , Chesnokova E. A. ,   Saint Petersburg University, Presnyakov R. A. ,   Association of Medical Law to St. Petersburg, Pryadko A. E. ,   Committee for social protection of the population of the Leningrad region, Zimina E. I. ,   Federal Research Institute for Health Organization and Informatics of Ministry of Health of the Russian Federation, Guryanova N. E. ,   Federal Research Institute for Health Organization and Informatics of Ministry of Health of the Russian Federation
Published: November 2020

The article analyzes the development trends of regional medical information systems in the field of health care. The authors pay special attention to the peculiarities of the development of regional medical systems, identify individual and general problems of these systems, and finally draw conclusions about the ongoing development of the legal framework of the Russian Federation in the field of e-health, and as a solution to the identified problems, they propose to form unified rules at the federal level containing general principles and provisions on regional medical information systems, including the electronic health records.
TECNOLOGÍA EN TIEMPOS DE COVID DE LA COMUNIDAD DEL INSTITUTO TECNOLÓGICO EDWARDS DEMING
Authors: Bilbao Maritza
Published: November 2020

Los problemas educativos a consecuencia de la pandemia por el COVID-19 encontraron solución en el uso de la tecnología de información y comunicación (TIC) con el uso de computadoras y todo equipo de telecomunicación de almacenamiento, transmisión y manipulación de datos. Hoy en día muchas personas pueden acceder a la información desde cualquier dispositivo inteligente. Sin embargo, hay un gran porcentaje de personas que no tienen acceso a estas herramientas y limitan sus posibilidades de estudios y por ende a entrar al mercado laboral con conocimientos certificados.
Corporate Governance dan Kinerja Keuangan
Authors: Sa’diyah Haniatus
Published: November 2020

This study aims to determine the effect of corporate governance as proxied by the Board of Commissioners, the Board of Independent Commissioners, the Board of Directors and the Sharia Supervisory Board on Financial Performance, through a connecting variable, namely Non Performing Financing (NPF). The sample of this research is using purposive sampling method. The population is 13 Islamic Commercial Banks in Indonesia. The samples obtained were 8 Islamic Commercial Banks. The data is obtained from the quarterly reports of each bank, namely the first quarter of 2017 to the second quarter of 2020. Data analysis and hypothesis testing methods use path analysis using panel data. The results of this study indicate that corporate governance as proxied by the Board of Commissioners, the Independent Commissioner, the Board of Directors and the Sharia Supervisory Board has no effect on financial performance and non-performing financing. This means that higher corporate governance does not affect financial performance or non-performing financing. In this study it was also found that non-performing financing has an effect on financial performance. If non-performing financing decreases, financial performance will increase. In addition, non-performing financing in this study cannot be an intervening variable for corporate governance.
Chandra Observations of the Newly Discovered Magnetar Swift J1818.0–1607
Authors: Blumer Harsha , Safi-Harb Samar
Published: November 2020

Swift J1818.0–1607 is a new radio-loud magnetar discovered by the Swift Burst Alert Telescope on 2020 March 12. It has a magnetic field B ∼ 2.5 × 1014 G, spin-down luminosity

 ∼ 7.2 × 1035 erg s−1, and characteristic age τ

c
 ∼ 470 yr. Here we report on the Chandra observations of Swift J1818.0–1607, which allowed for a high-resolution imaging and spectroscopic study of the magnetar and its environment. The 1–10 keV spectrum of the magnetar is best described by a single blackbody model with a temperature of 1.2 ± 0.1 keV and an unabsorbed flux of 1.9−0.3
+0.4 × 10−11 erg cm−2 s−1. This implies an X-ray luminosity of 9.6−1.5
+2.0×1034 d
6.5
2 erg s−1 and efficiency of

 ∼ 0.13 d
6.5
2 at a distance of 6.5 kpc. The Chandra image also shows faint diffuse emission out to

from the magnetar, with its spectrum adequately described by a power law with a photon index of 2.0 ± 0.5 and a luminosity of ∼8.1 × 1033 

erg s−1. The extended emission is likely dominated by a dust-scattering halo and future observations of the source in quiescence will reveal any underlying compact wind nebula. We conclude that Swift J1818.0–1607 is a transient source showing properties between high-B pulsars and magnetars, and could be powered at least partly by its high spin-down, similar to rotation-powered pulsars.
P/2019 LD2 (ATLAS): An Active Centaur in Imminent Transition to the Jupiter Family
Authors: Steckloff J. K. , Sarid G. , Volk K. , Kareta T. , Womack M. , Harris W. , Woodney L. , Schambeau C.
Published: November 2020

The recently discovered object P/2019 LD2 (by the Asteroid Terrestrial-impact Last Alert System) was initially thought to be a Jupiter Trojan asteroid, until dynamical studies and the appearance of persistent cometary activity revealed that this object is actually an active Centaur. However, the dynamical history, thermal environment, and impact of such environments on the activity of 2019 LD2 are poorly understood. Here we conduct dynamical simulations to constrain its orbital history and resulting thermal environment over the past 3000 yr. We find that 2019 LD2 is currently in the vicinity of a dynamical “Gateway” that facilitates the majority of transitions from the Centaur population into the Jupiter Family of Comets (JFC population). Our calculations show that it is unlikely to have spent significant amounts of time in the inner solar system, suggesting that its nucleus is relatively pristine in terms of physical, chemical, and thermal processing through its history. This could explain its relatively high level of distant activity as a recently activated primordial body. Finally, we find that the median frequency of transition from the Gateway population into the JFC population varies from once every ∼3 yr to less than once every 70 yr, if 2019 LD2's nucleus is ∼1 km in radius or greater than 3 km in radius. Forward modeling of 2019 LD2 shows that it will transition into the JFC population in 2063, representing the first known opportunity to observe the evolution of an active Centaur nucleus as it experiences this population-defining transition.
Global and Regional IUCN Red List Assessments: 10
Authors: Fenu Giuseppe , Al-Rammahi Hayder M. , Mohammad Mohammad K. , Perrino Enrico V. , Rosati Leonardo , Wagensommer Robert P. , Orsenigo Simone
Published: November 2020

In this contribution, the conservation status assessment of two vascular plants according to IUCN categories and criteria is presented. It includes the regional assessment of Jasione orbiculata Griseb. ex Velen. for Italy and of Vachellia gerrardii (Benth.) P.J.H.Hurter subsp. negevensis (Zohary) Ragup., Seigler, Ebinger & Maslin for Iraq.
Genèse de l’État mandataire
Authors: Mizrahi Jean-David
Published: November 2020

« Zone tribale du Nord-Yémen », « zone tribale de l’Ouest pakistanais », voilà bien des expressions qui reviennent dans l’actualité pour désigner des régions de confins farouchement réfractaires à l’imposition d’un nouvel ordre politique. Dès la fin du XIXe et au début du XXe siècle, les États européens, emportés dans leur mouvement d’expansion outre-mer, vinrent buter, en périphérie, sur ce type d’espace en quelque sorte interstitiel des relations internationales contemporaines. Dans ces zones où les agents traditionnels de la vie diplomatique pénétraient peu, ou mal, une expertise particulière, celle du renseignement et des agences de sécurité, parut s’imposer. Lorsque la France coloniale s’implante en Syrie et au Liban, au lendemain de la Première Guerre mondiale, elle doit précisément faire face à ce type de résistance, où se combinent turbulences tribales, désordres sociaux et effervescence identitaire. La lutte qui s’engage alors entre bandes armées locales d’une part, et Service des Renseignements de l’armée française de l’autre, dépasse, et de loin, le face-à-face purement martial, mais renvoie à un choc des violences, sociale et guerrière d’un côté, étatique et militaire de l’autre, dont il n’est pas sûr que la leçon ne vaille qu’au passé.
L’UNESCO oubliée
Authors: Renoliet Jean-Jacques
Published: November 2020

La faillite politique de la SDN ne doit pas faire oublier son action dans bon nombre de domaines techniques, souvent poursuivie après 1945 par des organismes dépendant de l’ONU. Ainsi, dans le domaine de la coopération intellectuelle, l’UNESCO a pris le relais de l’Organisation de Coopération Intellectuelle (OCI), qui a fonctionné de 1922 à 1946 et dont l’élément moteur a été l’Institut International de Coopération Intellectuelle (IICI). Ce dernier, malgré ses défauts - notamment son caractère élitiste - a été un véritable laboratoire de la coopération culturelle en vue de favoriser l’activité des intellectuels et la diffusion d’une conscience universelle et pacifiste. La présente étude retrace l’histoire de l’OCI de 1919 à 1946 et tente d’établir un bilan de l’action de l’IICI tout en rendant compte du fonctionnement d’une organisation internationale dans l’entre-deux-guerres, notamment dans ses rapports avec les États et en particulier avec la France, qui a été à l’origine de l’IICI et qui l’a hébergé à Paris de 1926 à 1946.
Network pharmacology-based analysis of effective components and mechanism of Rhizoma coptidis in treating diabetes
Authors: Zeng Qian-Qian , Cai Jia-Wei , Xu Yue , Li Lin , Chen Qiu , Yue Ren-Song
Published: November 2020

Objective:

To identify the active ingredients, potential targets, and mechanism of Rhizoma coptidis by bioinformatics method, and to explore the hypoglycemic effect of Rhizoma coptidis by in vitro experiments.

Methods:

The chemical components of Rhizoma coptidis were collected through database search, and oral bioavailability and drug-likeness were used for preliminary screening. The targets of Rhizoma coptidis and diabetes-related targets were collected by database retrieval and reverse docking techniques, and the biological process of cross-set proteins was analyzed. The inhibitory effects of Rhizoma coptidis on α-glucosidase, α-amylase activity, and advanced glycation end products (AGEs) were determined via in vitro experiments. In addition, the effects of Rhizoma coptidis on pre-adipocyte differentiation, absorption of glucose by adipocytes, and the level of intracellular triglyceride were investigated using the adipocyte differentiation model.

Results:

There were 11 potentially active ingredients in Rhizoma coptidis. IL-6, caspase-3, epidermal growth factor receptor (EGFR), MYC, and estrogen receptor 1 were considered as the key genes. The bioinformatics analysis showed that Rhizoma coptidis played an anti-diabetic role mainly via biological processes and signaling pathways including hormone receptor activity, glutathione binding, steroid binding, etc. In vitro experiments showed that the extract of Rhizoma coptidis inhibited the activities of α-glucosidase and α-amylase, and the generation of AGEs; meanwhile, the extract promoted the absorption of glucose by adipocytes. In addition, the extract of Rhizoma coptidis decreased triglyceride level.

Conclusions:

Our network pharmacology and in vitro experiments demonstrate the anti-diabetic effects and possible underlying mechanisms of Rhizoma coptidis extract.
Assessing the Management Effectiveness of Three Protected Areas in Ghana
Authors: Afriyie Jerry Owusu , Asare Michael O. , Danquah Emmanuel , Pavla Hejcmanová
Published: November 2020

Assessments of management effectiveness of protected areas offer vital information about threats and management issues at the protected area. However, these assessments are frequently conducted mainly at the internal management level, without input from the local communities that implicitly influence the resources of the protected areas. The aim of this study was to assess the effectiveness of three protected areas in Ghana—Kogyae Strict Nature Reserve, Gbele Resource Reserve, and Kalakpa Resource Reserve—using the Rapid Assessment and Prioritisation of Protected Areas Management assessment tool. The study included workshops with park managers and representatives from local communities, district assemblies, and the Environmental Protection Agency. Poaching, settlements, agricultural encroachment, poverty in nearby communities, and bush fires were identified as common pressures to all the assessed protected areas. The degree of these pressures was influenced by little or no funding, poor community relations, lack of staff and research, and natural resource inventories in the protected areas. Our study highlights the priority of remedial actions that are urgently needed to preserve the protected area resources.
Prescribed k-symmetric curvature hypersurfaces in de Sitter space
Authors: Ballesteros-Chávez Daniel , Klingenberg Wilhelm , Lambert Ben
Published: November 2020

We prove the existence of compact spacelike hypersurfaces with prescribed k-curvature in de Sitter space, where the prescription function depends on both space and the tilt function.
HIỆU ỨNG “SWITCHING” VÀ ỨNG DỤNG TRONG KỸ THUẬT CỦA HỢP CHẤT Ge2Sb2Te5
Authors: PHÚC NGUYỄN HUY
Published: November 2020

Hợp chất họ Chalcogenide trong đó Ge2Sb2Te5 được xem là ứng cử viên đặc biệt, được sử dụng trong các thiết bị lưu trữ thông tin, bởi chu trình lưu và xóa thông tin rất lớn (106 – 1013 lần) và thời gian lưu, xóa, đọc thông tin diễn ra rất nhanh (50s), gấp 103 lần so với những bộ nhớ dạng flash. Đồng thời việc lưu và xóa thông tin diễn ra không yêu cầu tốn nhiều năng lượng. Hiệu ứng “switching” và hiệu ứng nhớ là hai hiệu ứng song song, rất đặc trưng của Ge2Sb2Te5. Quá trình chuyển trạng thái từ điện trở cao đến điện trở thấp và ngược lại dưới sự tác dụng của xung điện đã tạo tiền để cho việc nghiên cứu và chế tạo tế bào nhớ pha (Phase Change Memory). Ứng dụng tính chất quang của hợp chất này đã có mặt trên thị trường. Đó là việc sử dụng hợp chất Ge-Sb-Te trong lớp lưu trữ thông tin của đĩa quang nhiều dạng khác nhau (CD-RW, DVD-RW, Blue-ray). Vì vậy, các nghiên cứu trong bài báo này tập trung vào tính chất điện, hiệu ứng “switching” của hợp chất Ge2Sb2Te5 và ứng dụng của chúng trong công nghệ kỹ thuật.
Aspectos relevantes del emprendimiento en Sudamérica
Authors: Feijó-Cuenca Tito Eliecer , Feijó-Cuenca Nilba Priscila
Published: November 2020

El evidente interés de la administración pública y privada en brindar apoyo a las iniciativas de creación de nuevo negocios, también es expresado por la academia a través de la elaboración de artículos de carácter científico hechos en Sudamérica, lo cual nos invita a analizar la producción investigativa generada en relación al emprendimiento en Sudamérica, para lo cual se desarrolló una exploración bibliográfica en una de las más respetables bases de datos existentes como lo es Scientific Electronic Library Online (Scielo), donde se tomó como buscador la palabra emprendimiento, así mismo se escogieron los artículos de carácter científico donde se evidencie que los estudios fueron realizados en Sudamérica. La información conseguida permitió evidenciar el crecimiento en la producción de artículos científicos concernientes al emprendimiento en Sudamérica, los artículos según el área de conocimiento y las revistas donde se realizan las publicaciones. Con los resultados obtenidos se espera crear nuevas expectativas para investigaciones futuras.

Palabras clave: Investigación en emprendimiento, emprendimiento en Sudamérica, análisis bibliométrico.
CALIDAD DEL PORTAFOLIO DE SERVICIOS DE LA POLICÍA NACIONAL DEL DISTRITO JIPIJAPA
Authors: Acebo-Pisco Rosa Judith , Anchundia-Loor Andrés Miguel
Published: November 2020

Este estudio se centró en analizar el portafolio de servicios que brinda la Policía Nacional ya que es el que posibilita al talento humano, liderando todos aquellos procesos comunitarios y desarrollando acciones preventivas, operativas y estratégicas conformadas por una serie de fortalezas en beneficio de la comunidad, cada uno de los servicios presentan sus ventajas, ya que son programas piloto a incrementarse en la medida que la ciudadanía tenga una alta receptividad, permitiendo aplicar una metodología de tipo transversal no experimental, descriptiva que permiten determinar la calidad del servicio policial del distrito Jipijapa, llevando a cabo cada etapa a la práctica conforme la realidad de cada sector, para efectividad de la mejora se efectuó la adopción de las normas ISO 9001; 2015 ya que estas consisten en organizar un sistema o procedimientos de calidad, reorganizar la institución acogiendo las normativas de calidad y sobre todo planificar una estrategia de mejora que representan como una institución crea y entrega valor a la ciudadanía constituyendo su trabajo y contribuyendo a la mejora de la calidad de servicios acorde a los requerimientos ciudadanos, de donde se concluye que al aplicar esta norma de estándar internacional la organización contará con viabilidad en tiempo y talento humano requerido para lograr los objetivos planteados.

Palabras clave: Satisfacción al usuario, policía nacional, ISO 9001, talento humano.
Pandemic effect on the elderly and their caregivers
Authors: Walarine Maryelizabeth Tidiya , K V Binoy Mathew
Published: November 2020

COVID-19 pandemic forced governments to enact mobility restrictions to contain the spread of infection. Elderly, especially those with co-morbidities, are highly susceptible to infections. Hence, reverse quarantine measures have been enacted to protect the elderly. The barriers in social connectedness have an impact on the mental and physical well-being of the elderly. Stress, anxiety, anger, confusion, depression, and suicidal tendencies are reported among the elderly kept in social isolation. Apart from the elderly, their family caregivers also go through similar physical and psycho-social stress. Many times, the caregivers are also having additional responsibilities of childcare and homeschooling during the pandemic time. The authors outline the various intricate issues and dimensions of the pandemic's effect on the elderly and their caregivers. Various feasible strategies to address these multidimensional problems faced by the elderly and their caregivers during the pandemic time, like mobile-based mindfulness meditation training, spiritual support, telephone-based psychotherapy, telehealth services, physical exercise promotion, and social support measures, are recommended.
The new norm in the management of COVID-19 positives: home-based care
Authors: Ilesanmi Olayinka Stephen , Oguntoye Abolanle Adesile , Afolabi Aanuoluwapo Adeyimika
Published: November 2020

Background: The Coronavirus disease (COVID-19) has disrupted health systems globally and locally. The increasing number of COVID-19 positives has overwhelmed healthcare facilities and health workers. Home-based care (HBC) is a new norm in the management of COVID-19 positives. We aimed to give insight into the HBC of COVID-19 positives in Nigeria.

Methods: We conducted a descriptive review of the existing literature and summarized the authors' opinions regarding HBC in Nigeria.

Results: HBC has increasingly gained recognition for the management of COVID-19 positives. The HBC of COVID-19 positives provides the opportunity for patient management under an atmosphere of emotional, physical, and spiritual fulfillment as required for quick recovery. Guidelines have been developed for HBC of COVID-19 positives; however, negligence to these measures has been noted.

Conclusion: To ensure compliance and harness HBC's benefits, community leaders, religious organizations, civil-based organizations, and opinion leaders should be actively involved in HBC activities. Also, enforcement authorities such as the Civil Defence Corps could help to improve adherence to HBC restrictions.
Práticas pedagógicas na educação do campo: o ensino de História e cultura afrobrasileira e africana
Authors: Nascimento Heliosa Helena Fonseca do , Silva Celma Rocha , Scalabrin Rosemeri
Published: November 2020

O presente estudo, de cunho exploratório, é parte da pesquisa intitulada “Metodologias de Ensino de História e Cultura Afro-brasileira e Africana na Educação Profissional e Tecnológica: Experiências do Ensino Médio Integrado no IFPA”, tem como objetivo discutir as práticas pedagógicas referente ao ensino de história e cultura afro-brasileira e africana no currículo integrado. O estudo traz um diálogo sobre os pressupostos que embasam o currículo integrado na Educação Profissional e Tecnológica (EPT) e do ensino de cultura afro-brasileira e africana no currículo integrado. A pesquisa traz uma discussão sobre a implementação da lei 10639/03 no currículo da EPT. Para a problematização partimos da pesquisa bibliográfica, documental e de campo, bem como de entrevista com 5 professores, no sentido responder como tem sido desenvolvida as práticas pedagógicas e como vem sendo organizada a matriz curricular no ensino médio integrado no curso de Agropecuária no Campus Rural de Marabá (CRMB)/Instituto Federal do Pará (IFPA). A pesquisa demonstra avanços na implementação da lei, porém, a necessidade de um planejamento coletivo e integrado do currículo no Projeto Pedagógico do Curso (PPC), bem como, da formação de professores para o ensino de história e cultura afro-brasileira e africana, no sentido de descolonizar o currículo e, portanto, de construir práticas pedagógicas desatreladas de uma concepção hegemônica e eurocêntrica.
O Bullying e suas consequências na cultura escolar
Authors: Moreira Adailson Silva , Souza Welton Rodrigues
Published: November 2020

O enfrentamento das expressões da violência torna-se um desafio na atualidade, principalmente para a escola, que reproduz a cultura mais ampla da sociedade, mas também produz uma cultura própria a partir do social. Esse trabalho tem por objetivo refletir sobre as relações entre cultura e violência no contexto escolar. Por isso foi realizado a partir de revisão de literatura que trata desta temática, através de buscas em bases de dados. A partir do material encontrado, foi possível traçar um panorama a respeito do bullying no ambiente escolar e suas repercussões na vida de agressores e vítimas. Os resultados evidenciaram que o bullying prejudica o desenvolvimento na infância e adolescência, gerando danos na fase adulta. Pode acarretar o desinteresse pela escola, déficit de concentração e aprendizagem, queda do rendimento, absenteísmo e evasão escolar, isolamento, tentativas de suicídio, agressividade, irritabilidade, ansiedade e relatos constantes de medo. Assim, concluímos que os objetivos de formação devem ir ao encontro da necessidade de formar sujeitos capazes de entender e viver num mundo marcado pela diversidade, rompendo com as questões de violência entre os alunos. Todavia, este é um processo de longo prazo que deve ser incorporado desde a formação dos professores.
Dampak Kawasan dan Status Negara Terhadap Pertumbuhan Ekonomi Negara-Negara Terdampak Covid-19
Authors: Junaedi Dedi , Salistia Faisal
Published: November 2020

Faisal Salistia

IAI Nasional Laa Roiba Bogor

faisalsalistia@laaroiba.ac.id

 

 

ABSTRACT

The COVID-19 pandemic has had multi-sectoral impacts, including disrupting the economic growth of many countries. This study aims to analyze the impact of the COVID-19 pandemic, fiscal capability as well as regional differences and country status on the economic growth of the affected countries. The method used is a quantitative method with a saturated sample of 135 countries, and a regression analysis approach with dummy variables. The results showed that the variables of pandemic cases, exposure time, population, regional differences and country status differences affected the economic growth of the affected countries (R2 0.6373). If the pandemic is under control and there is no disparity in management between regions and between countries, then global economic growth has the potential to be positive at 0.18%. If state spending is increased, it has the potential to reduce the impact of economic contraction by 0.27%. The management of the pandemic in the Asian, American and African regions is significantly different from that in the Australian region. Poor countries are different from developed countries, but not different from middle-income countries, in managing pandemics in their regions. In relative terms, the impact of the pandemic in Asia, America and Africa is heavier than other regions.
Trans-sphenoidal Surgery for Pituitary Adenoma – A Prospective Study
Authors: Talha K A , Kumar S , Selina F
Published: November 2020

Pituitary tumours constitute 10% to 25% of all intraeranial neoplasms. The goals of treatment of pituitary adenomas include normalization of hormonal secretion and resolution or cessation of the progression of neurological defects. hoot-minions may inclutk surgery. medical treatment. radiation therapy. or a combination of these modalities. The tramisphenoidal nticrosurgical approach to a pituitary lesion is the most widely used surgical approach to pituitary lesions and represents a major development the sqk surgical treatment of hods homonally active and nonfunctioning tumours. This is a prospective study of iranssphenoidal removal of paid.). tumours that Arm tarried ow in neurosurgery department of Apollo Hospital. Dhaka. Study period was of one year. All p0/i 55 who underwent transsphenoidal surgety for pituitary adenoma were included in this study. Aim of this stud, was to evohnue the cases of pituitary adenoma undergoing nonssphenoidal surgery from pathological and surgical point of view. The aini ma also to compare the results with other oldie. There was a male predominance in the patient population. Age of most of the patients was in between 91 000/ 50 wars. Presenting complaints were headache in 80% of cases followed by visual disturbance (70%) mul menstrual disturbance (20%). Size of pituitary adenoma was 10 mot or MINT in 90% of cases. Improwntent vision after surgery was achieved in 60% cases. HOI71101,01 status was improved in 70%.
Study of TVC Count and Haemoglobin Concentration in Female Athletes
Authors: Akhter D , Amin Md. R , Akhter N , Rahman Md. A , Islam Md. M
Published: November 2020

The present study was designed to observe ABC and haemoglobin concentration in female table/es. For this purpose, a total member of 60 /oaks. age ranged from 17-38 years. were selected Thirty of them were athletes 101IperillK011eli group) and 30 non-athletes (comrolh Athletes were selected form Dhanonadi Mohan Krira Comptes ad controls fiat students of Dhaka University. ROC man and haemoglobin concentration were measured by electronk reO water method. RBC moot was land significantly lower in athletes than that of controls but Mere was no change in haemoglobin concentration. The reat of the study 'weals that lowered RBC coma was due to mechanical damage of ersahrocytic membrane leading to shortening of mean life span of ROC.
Impact of Testosterone to Induce Benign Prostatic Hyperplasia in Long Evens Rats
Authors: Rahman Md. A , Haque G A , Akhter N , Naher S , Akhter D
Published: November 2020

This experimental softly was carried out in the Department of Anatomy, Sir Salintallah Medical College. Dhaka from January to December 2006. The objective of the study was to see the effects of testosterone on prostate and to measure the weight. length, transverse diameter and ameroposterior diameters the organ, and also to estimate transvenical diameter of acini and percentage of steam. Total .10 maimed male Long Evans nos of age 8-10 weeks and ',visiting 200 to 300 gnu tore used in this study. They were divided into Am equal groups. Group A was vehicle (ohm oil) control group and Group II tots testosterone treated group. The rats 'sere sacrificed on the eleventh day. It wat concluded dna testosterone induces hyperplasia of the prostate within In increased weight. length. transverse diameter anteroposterior diameter and higher values in trans-venical diameter of acitti and percentage of SIMINO.
High Level of Serum Lactate Dehydrogenase: A Diagnostic Maker of Childhood Acute Lymphoblatic Leukaemia
Authors: Hafiz Md. G , Rahman Md. M , Talukder A M , Islam A , Mannan M A
Published: November 2020

By the estimation of serum lactate dekthrogerrase (LDH). one may assnme the diagnosis of childhood acute ionphoblastic lenkaanin (ALL). This awe anneal study was aimed at evaluating the level of serum LOH at the initial presentation and to establish it as a diagnostic marker in childhood ALL The study was carried ma in the Paediatric Haematology and Oncology rink Bangabandthe Sheikh Mt& Medical University (BSMMU), Dhaka, during the period from Jamialy 2004 to December 2004 on 69 subjects with age ranging Jinni birth to 15 years irrespective of sex. The SII16. subjects were grouped into group 1: ALL (44)and group 11: healthy control (25). At the initial presentation. haematological investigations (Rh percentage. fond 1913C platelet coma and blast cell percernage)and measurement of. awn LDH nom done in both groups. But only in ALL patients bone Marrow blast cell percentage was done at the initial presentation. At admission. means SD of term LOH level in ALL patients and healthy contras were 2091.911 g 1073.20 and 362.32 x 89.69 Ulf. respectively. h was fraud that serum LOH levels were markedly elevated (more than 900 (UM in 36 (82M) and moderately elevated (upto 900 1U/L) only in eight (18%) ALL patients in the initial presentation. and a ray high serum LOH level was common in children with ALL at diagnosis and indicated a total nIll/011r load. Serum LDH level W. significantly raised in ALL patients than in control group (Pe 0.001). So. the measurement of serum LDH can be accepted as a good and reliable en:y11101k diagnostic marker at childhood ALL.
Nanofertilizers for enhancing nutrient use efficiency, crop productivity and economic returns in winter season crops of Rajasthan
Authors: KUMAR YOGENDRA
Published: November 2020

The results of 600 on-farm trials with 8 crops conducted during winter season in different districts of Rajasthan have proved that the quantity of urea being applied by the farmers to supply nitrogen to the crops can be successfully reduced to half. The yields obtained with 50% less nitrogen plus 2 sprays of nano-nitrogen in standing crops gave yields higher than that applied in most of the 8 crops tested in these trials. Apart from this, effect of the Nano-Zn and Nano-Cu was also evaluated. As the deficiencies of these micronutrients were not universal like nitrogen, the significant responses to these nanofertilizers depended on the magnitude of deficiency of specific micronutrients and the nature of the crops.These results clearly establish that with application of nanofertilizers, the nutrient use efficiency can be significantly enhanced as revealed by 50 per cent saving of urea through 2 sprays of Nano N.Nanofertilizers are considered as a novel approach towards saving of nutrients, in particular nitrogen, and protecting the environment.This paper describes the results of 600 on-farm trials conducted on 8 crops grown during winter season of 2019-20.
A New Ultra Low-Power and Noise Tolerant Circuit Technique for CMOS Domino Logic
Authors: Meher Preetisudha , Mahapatra K. K.
Published: November 2020

Dynamic logic style is used in high performance circuit design because of its fast speed and less transistors requirement as compared to CMOS logic style. But it is not widely accepted for all types of circuit implementations due to its less noise tolerance and charge sharing problems. A small noise at the input of the dynamic logic can change the desired output. Domino logic uses one static CMOS inverter at the output of dynamic node which is more noise immune and consuming very less power as compared to other proposed circuit. In this paper we have proposed a novel circuit for domino logic which has less noise at the output node and has very less power-delay product (PDP) as compared to previous reported articles. Low PDP is achieved by using semi-dynamic logic buffer and also reducing leakage current when PDN is not conducting.
CLIMATE CHANGE WITH SPECIAL REFERENCE TO RISK FACING SMALL ISLAND STATES
Authors: Patel Mr. Darshan V.
Published: November 2020

Climate change is the burning issue of the current era. Because of the advancement in the technology and accelerated use of fuels have lead to the increasing concentration of the Greenhouse gases. Greenhouse gases affect the climate system very badly. The Climate of the Earth varies naturally because of a variety of cosmological and geological processes but Climate change refers to an additional and relatively rapid change induced by human actions. The average temperature of the Earth is increasing very rapidly over the past 30 years and because of that the snow is melting on the glaciers and the sea water level is increasing gradually rapidly and as a result of that many temperature sensitive systems / processes have been disturbed and changed over the past two decades. The additional change of several degree centigrade (oC) with in a century will disrupt the foundations of life on Earth.
A Novel Fuzzy Logic Based Technique to Find the Criticality of Power Transformer
Authors: Rao U. Mohan , Jarial R. K.
Published: November 2020

Determining the current prevailing conditions in the transformer is still a challenge and an attempt is made for meeting the same challenge. In this paper a novel system based on fuzzy logic is developed which considers thermal, electrical and mechanical conditions prevailing in the transformer and gives the critical status of the transformer at an aggregate. The developed system also facilitates to give the critical condition of Paper thermal, Oil thermal, Partial discharge, Electrical arching, Dissolved gas analysis(DGA), Break down voltage and sweep frequency response analysis(SFRA) individually so that corresponding preventive measures can be taken by the technologists. This system consists of 10 fuzzy logic controllers whose connections are made by considering technical conditions and reasons, the corresponding rule bases of these fuzzy logic controllers were developed by considering various standards and experience of TIFAC CORE in NIT-Hamirpur. This fuzzy logic based system is tested for various transformers and found that it is highly précised in classifying the critical statues of any transformer as well as all identifying the current prevailing conditions.
The Metaphysics of Identity
Authors: Nechaev Aleksei
Published: November 2020

The paper proposes an approach to solving identity problems from the perspective of scientific philosophical materialism, whereby identity is defined as an objective social phenomenon independent of the individual’s ability for categorization.  Human being is studied in his/her action content as a social being that is ontologically divided in its essence and existence. Overcoming this alienation through adequate action provides the basis for identity formation in a social individual.