bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of bone metabolism regulators sclerotin and osteoprotegerin in the development of cardiovascular complications in the late stages of chronic kidney disease
Authors: Dzgoeva F. U. , Remizov O. V. , Botsieva V. Kh. , Malakhova N. G. , Ikoeva Z. R. , Goloeva V. G. , Gireyeva E. Yu. , Gurina A. E. , Tsallagova L. V.
Published: November 2021

BACKGROUND. Cardiovascular complications caused by vascular calcification in chronic kidney disease (CKD) are closely related to disorders of bone and mineral metabolism, the mechanisms of which require further study.

THE AIM: to clarify the role of the regulatory proteins of bone metabolism of sclerostin and osteoprotegerin in the processes of vascular calcification and the development of cardiovascular complications in CKD.

PATIENTS AND METHODS. 110 patients with stage 3-5D CKD (67 men) were examined. Median age is 47.0 (23.0-68.0) years. Osteoprotegerin (OPG), sclerostin, intact parathyroid hormone (IPTG), troponin I in blood serum were determined using commercial kits "Enzyme-linked Immunosorbent Assay Kit for Sclerostin" ("Cloud-Clone Corp.", USA) and commercial kits "ELISA kit" ("Biomedica" (Austria) by enzyme immunoassay (ELISA). Echocardiography with Dopplerography was performed on the device "ALOKA 4000" ("Toshiba", Japan). The left ventricular myocardial mass index (LVMI) and peak systolic blood flow velocity in the aortic arch (Vps, peak systolic velocity) were determined to quantify hemodynamic changes indirectly indicating the state of the aortic vascular wall.

RESULTS. Analysis of the ratios of the calculated glomerular filtration rate (EGFR), IMLJ, Vps, OPG, and sclerostin showed that a decrease in excretory kidney function is accompanied by an increase in the concentrations of OPG and sclerostin in the blood serum. At the same time, there is an increase in IMLJ and Vps. During the correlation analysis, it was shown that the level of OPG was positively correlated with the level of sclerostin and negatively with the level of iPTG.

CONCLUSION. In our study, we obtained data confirming the interactive interaction between the vascular and bone systems. Morphogenetic proteins-inhibitors of bone metabolism (sclerostin and OPG) play a significant role in the defeat of the cardiovascular system in patients with CKD, as they promotes the development of vascular calcification.
Vitamin D levels in patients with diabetes mellitus in combination with chronic kidney disease
Authors: Lichacheva A. P. , Agranovich N. V. , Klassova A. T. , Anopchenko A. S. , Solovyova E. L.
Published: November 2021

BACKGROUND. Vitamin D has been known since 1928. The wide range of its metabolic effects paradoxically contrasts with the high prevalence of insufficiency and deficiency in the population of different regions of the world. A number of publications have demonstrated information about the relationship between vitamin D and insulin production by beta cells of the pancreas, as well as the excretory function of the kidneys.

THE AIM: to assess the level of vitamin D in patients with diabetes mellitus in combination with chronic kidney disease (CKD).

PATIENTS AND METHODS. A questionnaire and a study of the level of 25-hydroxyvitamin D, creatinine, urea, and glucose in the blood were conducted in 117 patients aged 18 to 84 years who gave voluntary consent. All patients were divided into three study groups: group 1 - patients with long-term DM, group 2 - patients with newly diagnosed DM, and 3 - control group. The glomerular filtration rate (GFR) is calculated by the formula CKD-EPI.

RESULTS. As a result of the study, it was found that patients with DM, regardless of the duration of its course, were more likely to suffer from vitamin D deficiency, compared with the control group, where D-deficiency and D-deficiency occurred with the same frequency. In addition, patients with DM were more likely to have stage 2-3A CKD, in contrast to the control group, where preserved kidney function prevailed. We also identified and confirmed the direct dependence of GFR on the level of vitamin D in the blood of patients with DM.

CONCLUSION. In the patients studied by us, a clear association was found between a lower vitamin D index in the blood serum and the presence of a history of diabetes. They also showed a tendency to decrease the excretory function of the kidneys and the formation of CKD. Consequently, a full-fledged diagnosis of vitamin D-deficient conditions and timely initiated therapy can prevent or at least slow down the progression of CKD in these patients, which will certainly improve their quality of life and reduce the costs of health services for renal replacement therapy and rehabilitation of this group of patients.
Epigenetic mechanisms of nephroprotection in diabetic nephropathy: focus is on sirtuin-1
Authors: Aitbaev K. A. , Murkamilov I. T. , Fomin V. V. , Murkamilova Zh. A. , Yusupov F. A.
Published: November 2021

Numerous studies have shown the critical role of sirtuin-1 deacetylase (SIRT1) in the protection of renal cells from endogenous and exogenous stresses. A protective role for SIRT1 has been established in both podocytes and renal tubular cells in many kidney diseases, including diabetic nephropathy (DN). SIRT1 has also been shown to have nephroprotective effects in DN, in part through the deacetylation of transcription factors involved in disease pathogenesis, such as p53, FOXO, RelA / p65NF-KB, STAT3, and PGC1a / PPARy. Recently, it was found that podocyte-specific overexpression of SIRT1 attenuates proteinuria and kidney damage in an experimental model of DN, suggesting the possibility of using SIRT1 as a potential target for the treatment of kidney disease. In addition, SIRT1 agonists such as resveratrol and BF175 have been shown to reduce diabetic kidney damage in several experimental animal models. It has also been shown that puerarin, a Chinese herbal medicine, activates SIRT1, providing nephroprotection in a mouse model of DN. In addition to SIRT1 agonists, inhibitors of bromodomain, in particular, MS417, also have a nephroprotective effect. These results suggest that SIRT1 agonists and bromodomain inhibitors may be new potential therapeutic agents that slow the progression of DN.
Clinical and morphological presentation of C3 glomerulopathy: a single-center study of 60 cases
Authors: Dobronravov V. A. , Karunnaya A. V.
Published: November 2021

INTRODUCTION. СЗ-glomerulopathy (СЗ-GP) is a spectrum of diseases caused by dysregulation of the alternative complement pathway. The present study was carried out taking into account the limited number of foreign and the absence of original studies in the Russian population.

THE AIM. Analysis of clinical and morphological manifestations of СЗ-GP at the time of primary diagnosis.

PATIENTS AND METHODS. Retrospective analysis of the etiology, clinical data and morphology of СЗ-GP identified in the period 2006-2021.

RESULTS. The study included 60 cases. The average age of patients is 4З±17 years. Nephrotic syndrome was detected in 47 % of patients; in 58 % of cases the estimated glomerular filtration rate was <60 ml/ min/иЗ m2. The dominant morphological pattern was membranoproliferative glomerulonephritis (75% cases). In 2 cases, СЗ-GP debuted with clinical and morphological manifestations of the disease of minimal changes, in which the identification of characteristic electron-dense deposits became obvious when performing a second biopsy. 4 cases had at the onset classical signs of complement-mediated thrombotic microangiopathy (atypical hemolytic uremic syndrome) in combination with C3-GP or its subsequent development.Ultrastructural examination was performed in 40 cases. 8 patients (20%) were diagnosed dense deposit disease, 32 patients - C3-glomerulonephritis. Primary C3-GP was detected in 87 % of patients, secondary - in 13 % (monoclonal gammopathies - 10 %, autoimmune diseases - 3 %).Increased level of antibodies to factor H was detected in 2 of 12 patients who underwent this study. Nucleotide variants of unknown clinical significance in complement genes were detected in 2 out of 6 patients during molecular genetic testing.

CONCLUSION. C3-GP is a severe variant of glomerular damage with a heterogeneous etiological structure, which requires the use of ultrastructural and molecular diagnostics, as well as clinical analysis and identification of pathogenetic mechanisms to determine approaches to therapy.
PANDEMIA E SEDENTARISMO: CONSEQUÊNCIAS PARA A INFÂNCIA E ADOLESCÊNCIA
Authors: Santos Pedro Afonso Pegoretti Matias dos , Domingues Natália Stéfane de Godoi , Oliveira Mariana Rabelo de , Martelli Anderson , Delbim Lucas
Published: November 2021

No final de 2019 observou-se o início de uma pandemia causada pelo SARS-CoV-2 causador da Covid 19. Para controlar a propagação deste vírus foram determinadas medidas de segurança como o distanciamento social, levando o fechamento de diferentes estabelecimentos com consequências físicas, psicológicas e socioeconômicas, além de diversas mudanças no estilo de vida de pessoas em todas as idades. O presente estudo abordou a influência das adaptações decorrentes das condições de isolamento social sobre o sedentarismo e problemas relacionados, reforçando a importância da atividade física entre crianças e adolescentes ainda que no meio de uma pandemia, para uma melhor saúde e prevenção de doenças crônicas. Foi realizado uma pesquisa de artigos publicados entre os anos de 1995 a 2021 retratando as consequências da pandemia e o sedentarismo sobre esse grupo de pessoas. Evidências científicas indicaram aumento no tempo de inatividade física após o início da pandemia, sobretudo pelas mudanças nos hábitos diários e distanciamento social e a atividade física é um quesito indispensável para a melhora na qualidade de vida das crianças e adolescentes.
KETERKAITAN PENDIDIKAN KARAKTER DALAM MATERI NORMA DAN KEADILAN MATA PELAJARAN PPKN KELAS 7 SMP/MTS
Authors: Syafawati Zulfah Lis , Marzuki Marzuki
Published: November 2021

AbstractThis study aims to analyze the relationship between values education and character education in the material of norms and justice for grade 7 SMP/MTs subjects of Pancasila and Citizenship Education. This study uses a qualitative approach by means of library research as a technique of collecting data from various related references to analyze content. The results of the study indicate that value education and character education in civic education have an integrated relationship with each other. With value education, students have values in themselves which are considered good, right, worthy and valuable to take action. Actions based on these values are manifested in character education as a guide for good behavior in the family, school, friendship, community. Good character values must always be instilled in children from an early age so that they become good habits and reflect human beings who have character and are civilized or make good citizens. The values contained in character education are manifested in civic education subjects, one of which is in the material of norms and justice for grade 7 SMP/MTs.Keywords: education, character, values, normsAbstrakPenelitian ini bertujuan untuk menganalisis keterkaitan pendidikan nilai dan pendidikan karakter dalam materi norma dan keadilan kelas 7 SMP/MTs mata pelajaran Pendidikan Pancasila dan Kewarganegaraan. Penelitian ini menggunakan pendekatan kualitatif dengan cara studi kepustakaan sebagai teknik pengumpulan data dari berbagai referensi yang terkait untuk menganalisis konten. Hasil penelitian menunjukkan bahwa Pendidikan nilai dan pendidikan karakter dalam pendidikan kewarganegaraan saling memiliki keterkaitan yang terintegrasi. Dengan pendidikan nilai, peserta didik memiliki nilai-nilai dalam diri yang mana dianggap baik, benar, layak dan berharga untuk melakukan tindakan. Tindakan berdasarkan nilai tersebut terwujud dalam pendidikan karakter sebagai pedoman dalam bertingkah laku baik di lingkungan keluarga, sekolah, pertemanan, masyarakat. Nilai-nilai karakter yang baik harus selalu ditanamkan sejak dini kepada anak-anak agar menjadi kebiasaan yang baik dan mencerminkan manusia yang berkarakter serta beradab atau menjadikan warga negara yang baik. Nilai-nilai yang terkandung dalam pendidikan karakter diwujudkan dalam mata pelajaran pendidikan kewarganegaraan, salah satunya pada materi norma dan keadilan kelas 7 SMP/MTs.Kata kunci: pendidikan, karakter, nilai, norma
Stubble burning: Root cause, impacts and its management in Indian scenario
Authors: Gottipati Rohith , Burra Pavan M N , Menon Sandeep
Published: November 2021

The practice of purposefully setting fire to the residue that remained after harvest of rice and wheat crop is increasing periodically.  Stubble burning has become one of the challenging issues in India in recent times. Government has been consistently instructing farmers not to burn the crop residues, instead asking them for in-situ management. Farmers are citing various complications in stubble management which pulling them to setting up fire to the stubble. Rice straw burning generates life threatening greenhouse gases which causes air pollution injury. Particulate matter (PM2.5) levels in the capital state of India (New Delhi) have been exceeded by 14 times than threshold level because of episodic agricultural fires in the neighbouring states namely Punjab, Haryana. A very limited study has been done so far on this complete issue despite of its importance. The present review tried to expose root cause, impacts on ecosystem and management strategies of stubble burning especially in India. There are plethora of possibilities in managing residue in sustainable ways including in-situ residue management, mushroom production, livestock feed, composting, biochar preparation, bio-thermal power plants and paper industries. Mechanical and effective method of in-situ management has been come into existence in the form of happy seeder. Depending on the land holding farmers can follow any of the said methods and manage their residue in sustainable way by overcoming the constraints thereby reducing the impacts on ecosystem.
Rapid in-vitro micropropagation of Bamboo (Dendrocalamus strictus) and its genetic fidelity testing using ISSR markers
Authors: Khare Shambhu Ram , Kharate Pawankumar S. , Sahu Ritesh kumar , Jha Zenu
Published: November 2021

Bamboo is a versatile, arborescent, perennial and non-wood forest tree with tremendous commercial importance. For mass scale propagation of bamboo, the micropropagation is an effective way for producing elite, infection free and true-to-type planting material. Here, the nodal explants of Dendrocalamus strictus used to develop an effective protocol for micropropagation based on tissue culture technique. In this study, the sterilization treatment of 70% ethanol + Tween 20 + Bavistin  + Hgcl2 + PPM was successfully controlled the contamination up to 90 % as compared to other treatments. The shoots were initiated from nodal segments in MS medium supplemented with BAP (4 mg/l) and PPM (500µl/l). Shoot multiplication was found best with BAP (4 mg/l) and kinetin (2 mg/l) by using liquid MS medium. Whereas, rooting in solid MS medium has shown good results when supplemented with NAA (4mg/l). Healthy and disease-free plants were obtained after hardening under greenhouse conditions. Genetic fidelity testing by using ISSR markers reported that there was no variation in plantlets developed through micropropagation.
PROBLEMS OF CREATING A SINGLE HISTORY TEXTBOOK IN THE CONTEXT OF CONSTRUCTING STATE IDEOLOGY
Authors:   Kemerovo State University, Gavrilov O.F. , Gavrilov E.O. ,   Kemerovo State University
Published: November 2021

The article shows the connection of the discussion about the creation of a single history textbook with attempts to build state ideology. It has been found that the idea of a single state ideology correlates with the idea of a single history textbook. The implementation of this idea is hindered by the development factors of modern Russia. The implementation of this idea is hindered by the development factors of modern Russia. One of the main reasons is the contradiction caused by the duality of the goals of the modern political system of the Russian Federation: building unity in a pluralistic society.
ПРО ПІДГОТОВКУ І ПІДВИЩЕННЯ КВАЛІФІКАЦІЇ ФАХІВЦІВ У ДЗВО «УНІВЕРСИТЕТ МЕНЕДЖМЕНТУ ОСВІТИ» НАПН УКРАЇНИ В УМОВАХ ЗМІШАНОГО НАВЧАННЯ
Authors: Kyrychenko Mykola
Published: November 2021

У доповіді представлено реалізацію змішаного навчання в ДЗВО «Університет менеджменту освіти» НАПН України, що зумовлено пріоритетними завданнями формування інноваційного середовища підготовки та підвищення кваліфікації фахівців. Зосереджено увагу на впровадження он-лайн технологій, ґрунтовних змін у підходах до організації навчання в Університеті з відповідними методичними підходами та моделями. Розглянуто складові організації освітнього процесу: організаційну (нормативна база, технологічне забезпечення, матеріально-технічна база, створення цифрових робочих місць, опанування викладачами та здобувачами освіти цифровими технологіям, оволодіння науково-педагогічними працівниками необхідними компе-тентностями, створення контенту курсів та навчальних дисциплін); методичну (модель «перевернутого навчання», використання он-лайн курсів, навчально-методичне забезпечення, авторські курси, академічна мобільність); технологічну (навчальні платформи, цифрові інструменти). Проаналізовано підготовку та підвищення кваліфікації фахівців в умовах змішаного навчання в системі формальної, неформальної та інформальної освіти шляхом створення єдиної освітньо-цифрової екосистеми. Охарактеризовано організацію підвищення кваліфікації в «Українському відкритому університеті», що реалізується на основі хмарних технологій в системі неформальної освіти. Представлено результати моніторингу ключових показників освітнього середовища.
ANALYSIS OF THE POSSIBILITY OF FORMING A STRUCTURAL SYSTEM FOR DEVELOPING ALTERNATIVE OPTIONS OF THE TECHNOLOGICAL PROCESS OF HOT VOLUME FORMING AT THE STAGE OF TECHNOLOGICAL PREPARATION OF PRODUCTION
Authors: Шибаков Владимир Георгиевич , Панкратов Дмитрий Леонидович , Низамова Лилия Миннуровна , Низамов Равиль Салимович
Published: November 2021

Рассмотрена возможность оценки альтернативной технологии на этапе технологической подготовки производства.

The possibility of evaluating an alternative technology at the stage of technological preparation of production is considered.
Urgensi Beracara di Pengadilan Perdata Terhadap Hukum Acara perdata
Authors: Puhi Oyaldi , Akili Rustam Hs , Ahmad Ibrahim , Moonti Roy Marthen , Nuna Muten
Published: November 2021

Hukum acara perdata merupakan hukum perdata formil, yang pada dasarnya berfungsi mempertahankan atau menegakkan hukum perdata materiil melalui pengadilan apabila terjadi pelanggaran terhadap hukum perdata materiil atau terjadi sengketa. Bahkan hukum acara perdata juga mengatur bagaimana tata cara memperoleh hak dan kepastian hukum manakala tidak terjadi sengketa melalui pengajuan “permohonan” ke pengadilan. Artikel ini ingin menjelaskan bagaimana mekanisme beracara di pengadilan perdata terhadap hukum acara perdata, dengan menggunakan metode penulisan secara normatif. Sebagai kesimpulan, artikel ini menjelaskan bahwa didalam beracara hukum acara perdata dapat ditinjau dalam dua aspek yakni dalam arti luas dan dalam arti sempit, dalam arti luas beracara meliputi segala tindakan hukum yang dilakukan, baik di luar maupun di dalam persidangan di pengadilan guna menyelesaikan suatu perkara menurut ketentuan hukum acara perdata. Sedangkan dalam arti sempit, beracara meliputi tindakan beracara di dalam persidang di pengadilan dari sidang pertama sampai dengan hakim menjatuhkan putusannya. Sedangkan untuk prosedur dalam pengajuan Gugatan di Pengadilan merujuk pada Pasal 118 ayat (1) Herizen Indlandsch Reglement (“HIR”)/Pasal 142 RBg.

Abstract. Civil procedural law is formal civil law which basically is to defend or enforce material civil law through the court if there is a violation of the law toward material civil law or a dispute. Even the civil procedural law also regulates how to obtain legal rights and certainty, if there is no dispute through filing an "application" to the court. This article aims to explain how the procedure of mechanisms in civil courts toward civil procedural law by using the normative writing method. In conclusion, this article explains that civil procedural law proceedings can be viewed in two aspects, which are broad sense and narrow sense. In the broad sense, it includes all legal actions that are taken both outside and inside the court to resolve the case according to the provisions of civil procedural law. Whereas in a narrow sense, it includes proceeding at trial in court from the first trial until the judge makes his decision. whereas, the procedure for filing a lawsuit in court is referring to Article 118 paragraph (1) Herizen Indlandsch Reglement (“HIR”) / Article 142 RBg.
TRANSGÊNICOS: COMO ESTES SÃO CONHECIDOS PELOS ALUNOS DE CIÊNCIAS BIOLÓGICAS?
Authors: Fragoso Jane Elen Almeida , Matos Renata Fernandes de
Published: November 2021

Os transgênicos são organismos geneticamente modificados obtidos mediante a inserção de material genético oriundo de outro organismo, geralmente, de uma espécie diferente. Apesar da polêmica que gira em torno dos transgênicos, grandes benefícios podem ser observados com sua utilização. Com o objetivo de identificar o conhecimento que alunos de um curso de Ciências Biológicas apresentam sobre os produtos transgênicos, foi desenvolvida uma pesquisa do tipo quali-quantitativa em uma instituição de ensino superior pertencente a Universidade Estadual do Ceará, na qual foram entrevistados 90 alunos. A coleta de dados se deu por meio da aplicação de um questionário, sendo os dados categorizados, transformados em porcentagens e apresentados na forma de gráficos e tabelas. Pelos resultados obtidos ficou claro que o tema transgênicos precisa ser melhor trabalhado no âmbito acadêmico, sendo identificadas deficiências na aprendizagem dos alunos. Dessa forma, é necessário que estratégias de aprendizado sejam desenvolvidas, sendo de grande viabilidade a associação dos conhecimentos com o dia a dia dos alunos.
A IMPORTÂNCIA DA AFETIVIDADE NA RELAÇÃO PROFESSOR/ALUNO NA APRENDIZAGEM DA CRIANÇA COM TRANSTORNO DO ESPECTRO AUTISTA - TEA NA EDUCAÇAO BÁSICA
Authors: Silva Fabio , PERUSSI DEISE
Published: November 2021

Faz-se notória desde há algum tempo, a preocupação de pesquisadores, estudiosos e docentes com o processo educacional de crianças com Transtornos do Espectro Autista - TEA. O tema foi selecionado pela necessidade de evidenciarmos teoricamente, se a afetividade pode ser elemento fundamental a influenciar o desenvolvimento infantil da criança com Transtorno do Espectro Autista – TEA. O problema que deu origem a esta investigação e que impôs este estudo foram os seguintes questionamentos: como proporcionar a estudantes com TEA uma educação inclusiva de qualidade, que seja, ao mesmo tempo motivadora ao estudante enquanto impulsione seu desenvolvimento global? A busca por responder tais questionamentos se justifica por termos, na instituição onde atuamos como docente, alunos com Transtorno do Espectro Autista – TEA. Assim sendo, nosso objetivo consiste em conhecer, através da revisão da literatura específica, se a afetividade pode influir significativamente na aprendizagem das crianças com Transtorno do Espectro Autista – TEA. Buscamos subsídios teóricos em Wallon e Vygotsky tendo por objetivo confirmar ou negar a idéia de que a afetividade possa ser elemento fundamental a influenciar o desenvolvimento do aluno com TEA. Obtivemos a comprovação de que ensinando com afetividade, o docente conseguirá que seu aluno aprenda efetivamente.
ORIGENS HISTÓRICAS DA VACINAÇÃO NO BRASIL
Authors: Rosado Roberta Coely Lira Santos , Bessa Marcos Vinicius Holanda Bessa Vinicius , Nascimento Ingrid Milena Lopes do , Oliveira Antonio Jocilan dos Santos de , Moura Joed Soares de , Azevedo Sâmya Pires Batista de , Lima Allan Michel Bezerra , Neto Paulo Holanda Ponto , Barros Rodrigo José Fernandes de , Holanda Jamile Rodrigues Cosme de
Published: November 2021

Desde o início da humanidade, há a busca por uma melhor qualidade de vida, bem como há o surgimento de algumas patologias, e dessa forma necessita-se da criação de técnicas que permitam a prevenção de doenças, principalmente as infectocontagiosas. O presente estudo se propõe a apresentar, por meio de uma ampla abordagem teórica, as questões em torno do avanço da vacinação no Brasil, o processo de defesa da população por meio de imunizantes e quais os avanços considerados pela medicina nesse processo, que tem se mostrado tão importante no período de pandemia pelo qual o mundo atravessa. Para tal foi realizado uma revisão da literatura embasada no periódico CAPES, com as palavras chaves “vacina”, “Brasil”, “princípio”, “origem” de forma associada com o operador booleano “AND”, quanto aos filtros aplicados foram a de estar disponível na integra de forma online e o do texto encontrar-se em português, não sendo aplicado o filtro de período de tempo, já que objetivava encontrar artigos que mencionassem o início da vacinação no Brasil. Ressalta-se que alguns sites também foram consultados, como o da Fiocruz. O qual possibilitou realizar um resgate histórico sobre o processo de vacinação, sua origem e o início da obrigatoriedade da mesma no Brasil.
Department of Experimental Research (Brief Historical Summary)
Authors: Korolev Yu. N.
Published: November 2021

Основные направления научных исследований отдела экспериментальных исследований — изучение клеточных и внутриклеточных механизмов адаптации при применении природных и искусственных лечебных физических факторов в целях повышения их устойчивости к сильным патогенным воздействиям; разработка и обоснование принципов регуляции адаптивных процессов в различных функциональных системах организма. В последние годы в отделе проводятся научные исследования по изучению механизмов первичной и вторичной профилактики пострадиационных и стрессогенных нарушений в мужской репродуктивной системе с применением сочетанных немедикаментозных лечебных факторов.
Levels of methylated arginines and L-arginine in patients with polycystic ovary syndrome: a promising approach in clinical evaluation
Authors: OZTAN Ozgur , ERDOĞAN Gökçen , ŞİMŞİR Coşkun , TÜRKSOY Vugar Ali , ABUŞOĞLU Gülsüm , TUTKUN Lütfiye , DENİZ Serdar , ALAGÜNEY Mehmet Erdem
Published: November 2021

Aim: Polycystic ovary syndrome (PCOS) is a prevalent disease in women. PCOS is related with metabolic syndrome and associated with cardiovascular disorders. Methylated arginine is involved in endothelial dysfunction, inflammation and atherosclerosis pathophysiology. Our aim is to determine the association between PCOS and methylated arginine metabolites in order to investigate the role of vascular factors in the etiopathogenesis of PCOS.

Material and Method: This is a case-control study. The study group is consisted of 45 PCOS cases and 45 controls. The case group is patients who applied to Department of Gynecology and diagnosed with PCOS. Control group is consisted of healthy volunteers who applied to the outpatient clinics for other reasons. The study took place in Department of Gynecology in XX hospital. Data collection was held between 2018 October to 2019 June. Methylated arginine derivatives such as ADMA, SDMA, L-NMMA (L-NG-monomethyl Arginine Acetate) and also arginine and citrulline were determined.

Results: ADMA, SDMA, L-NMMA, arginine, citrulline, Arginine/ADMA, SDMA/ADMA and total methylarginine parameters showed statistically significant differences between groups. Strong positive relation was determined between scoring of Ferriman-Gallway (FGS) and luteinizing hormone (LH), glucose, insulin, ADMA, citrulline, homoarginine, L-NMMA and total methylarginine levels.

Conclusions: High levels of methylated arginine/NO pathway metabolites in PCOS patients may be related with cardiovascular outcomes of PCOS.
Combined effects of the implementation of magnesium and ascorbic acid on myocardial ischemia-reperfusion in open heart surgery
Authors: GÜLTEKİN Yıldırım , GÜZEL Abdulkadir , KARAKAYA Atalay , BEŞOĞUL Yavuz
Published: November 2021

Aim: This study aimed to investigate the combined effects of magnesium (Mg) and high dose ascorbic acid on cardiac ischemia-reperfusion (IR) injury.

Material and Method: This study was performed on 45 patients that were scheduled for coronary artery bypass graft (CABG) operations. The patients were divided into three equal groups. Group C received 50 mg/kg ascorbic acid; Group CM received the same dose of ascorbic acid plus 30 mg/kg Mg; Group K received neither ascorbic acid nor Mg. At various times during the operation, the blood levels of malondialdehyde (MDA), serum creatine kinase MB (CK-MB), and lactate dehydrogenase (LDH) levels were analyzed.

Results: There were statistically significant decreases in arrhythmia requiring intervention in Group CM compared to Group K (P=0.026). MDA levels increased in all groups but MDA 2 and MDA 3 levels were found to be statistically significantly lower in Group C and Group CM than in Group K (P=0.009, P=0.012, P=0.009 and P=0.006 respectively). However, inhibition of lipid peroxidation in both Group C and Group CM was not parallel to cardiac enzymes and hemodynamic measurements. There was no significant statistical difference in the cardiac enzyme levels between Group K, Group C, and Group CM (p>0.05).

Conclusion: To reduce the IR, Mg with a high dose of ascorbic acid may be efficacious in patients undergoing cardiac surgery. A larger population group is needed to prove the results of this study.
DO ECONOMIC GROWTH AND ENVIRONMENT QUALITY CONTRIBUTE TO TOURISM DEVELOPMENT IN EU COUNTRIES? A PANEL DATA ANALYSIS
Authors: Badulescu Daniel , Simut Ramona , Mester Ioana , Dzitac Simona , Sehleanu Mariana , Bac Dorin Paul , Badulescu Alina
Published: November 2021

The positive impact of the tourism industry on economic growth, revenues, infrastructure, employment, social inclusion and poverty reduction, although widely recognised, has been lately weighted against the appearance and exacerbation of several problems, such as: environmental footprint, increase of income inequality, cost increases related to solid waste collection, energy consumption, increased global CO2 emissions. On the other hand, the tourism sector is not just an active economic, societal, or environmental change agent; in turn, the tourism sector supports or is highly influenced by various factors, such as climate change, economic, political, or social factors. More recently, this industry has been highly impacted by the pandemic, technological developments and cultural trends. In this article we examined both the short and long-run relationship between tourism development and economic growth, CO2 emissions and energy consumption in European Union member states (EU27), by using the Principal Component Analysis (PCA) technique and autoregressive distributed lag (ARDL) model for panel data. The findings suggest that economic growth and energy consumption have a statistically significant impact on the tourism index both in the short and long-run, whereas CO2 emissions only have a significant impact upon the tourism index on the long run.
Active Galactic Nuclei Abundance in Cosmic Voids
Authors: Mishra Hora D. , Dai Xinyu , Guerras Eduardo
Published: November 2021

The abundance of active galactic nuclei (AGN) in cosmic voids is relatively unexplored in the literature, but can potentially provide new constraints on the environmental dependence of AGN activity and the AGN-host coevolution. We investigated AGN fractions in one of the largest samples of optically selected cosmic voids from Sloan Digital Sky Survey Data Release 12 for redshift range 0.2–0.7 for moderately bright and bright AGN. We separated inner and outer void regions based on the void size, given by its effective void radius. We classified galaxies at a distance <0.6 R
eff as inner void members and galaxies in the interval 0.6 < R/R
eff < 1.3 as outer void galaxies. We found higher average fractions in the inner voids (4.9 ± 0.7)% than for their outer counterparts (3.1 ± 0.1)% at z > 0.42, which clearly indicates an environmental dependence. This conclusion was confirmed upon further separating the data in narrower void-centric distance bins and measured a significant decrease in AGN activity from inner to outer voids for z > 0.42. At low redshifts (z < 0.42), we find very weak dependence on the environment for the inner and outer regions for two out of three bins. We argue that the higher fraction in low-density regions close to void centers relative to their outer counterparts observed in the two higher-redshift bins suggests that more efficient galaxy interactions may occur at a one-to-one level in voids that may be suppressed in denser environments due to higher velocity dispersions. It could also indicate less prominent ram pressure stripping in voids or some intrinsic host or void environment properties.
Anatomy of the leaf blades of Waldsteinia ternata (Stephan) Fritsch (Rosaceae) grown under different light conditions
Authors: Belaeva Tatiana N. , Butenkova Alina N.
Published: November 2021

AbstractThe paper reports the results of a comparative study of the anatomical structures of the leaf blades of Waldsteinia ternata grown under different light conditions in the Siberian Botanical Garden of Tomsk State University. Waldsteinia ternata is a tertiary nemoral relict from the mountains of southern Siberia, which is found in a limited number of taiga communities due to narrow environmental tolerance to various factors. The species remains poorly studied; comprehensive studies of the anatomical features of its leaves have not been performed on the territory of Russia. Leaves of W. ternata are dorsoventral and amphistomatous with anomocytic type stomata. The plants are classified as mesophytes. The relationship between the development of the anatomical structure of leaves and light conditions was revealed. The W. ternata plants grown in the sun showed an increased number of stomata and epidermal cells, an increased thickness of the leaf and mesophyll, and an increased number of cells of the upper and lower epidermis, that is, the plants exhibited heliophytic features of plant adaptation to good light conditions. At the same time, the vascular tissues of the plants grown in the sun were less developed, which reflected their adaptation to unfavorable water conditions. A number of relative indicators, such as the stomatal index of the lower epidermis, the ratio of the palisade to spongy mesophyll, and the ratio of xylem to phloem, did not change under different growth conditions. Thus, under different light and water conditions, W. ternata acquires helioxeromorphic or sciomesomorphic features.
Possible effect of alkalization therapy on SARS-CoV-2 virus lifecycle
Authors: Elsadani Khaled
Published: November 2021

This proposal tries to drive attention to the observation that pH variation plays a fundamental role in the functional mechanism of SARS-CoV-2 virus proteases. Depending on this role, testing the effect of alkalization therapy on the SARS-CoV-2 patients could be reasonable.
On two new species of deep-sea carrier crabs (Crustacea, Brachyura, Homolodromiidae, Dicranodromia) from Taiwan and the Philippines, with notes on other Indo-West Pacific species
Authors: Ng Peter K. L. , Yang Chien-Hui
Published: November 2021

The systematics of four species of the homolodromiid genus Dicranodromia A. Milne-Edwards, 1880, from East Asia and the Philippines is reappraised: D. danielae Ng & McLay, 2005, D. doederleini Ortmann, 1892, D. karubar Guinot, 1993, and D. martini Guinot, 1995; and key characters such as the epistome, gonopods, and spermatheca are figured in detail. Two new species, D. erinaceussp. nov. and D. robustasp. nov., are described from Taiwan and the Philippines, respectively. Dicranodromia erinaceussp. nov. resembles D. spinulata Guinot, 1995, and D. delli Ahyong, 2008 (from New Caledonia and New Zealand) but can be separated by its distinctly spinulated carapace surfaces and proportionately shorter fifth ambulatory legs. Dicranodromia robustasp. nov. is superficially similar to D. baffini (Alcock & Anderson, 1899) and D. karubar Guinot, 1993, but can easily be separated by possessing a broad dorsoventrally flattened infraorbital tooth. A genetic study of the species using the mitochondrial cytochrome c oxidase I gene confirms that the taxa are distinct, with D. erinaceussp. nov. coming out in a well-supported clade from congeners. The megalopa of D. doederleini is also reported for the first time.
Think Before You Flush! A Sustainable Aquatic Eco-System’s Relation to Human Health
Authors: McKeown Elaine , Pawloski Judith
Published: November 2021

What we do every day at work and in our home lives can make a difference in the quality of our environment. Consider, for example, the flushing of pharmaceuticals into the sewer system can lead to water pollution resulting in a threat to aquatic and human life. In contrast, keeping aquatic life healthy may contribute to human health. Some aquatic-based medications are currently on the market. Others are in various stages of development. In this article the authors argue that, for the benefit of both human and marine life, it is time to implement safer disposal methods for unwanted medications. The authors begin by sharing nursing’s guiding principles for environmental health; after which they review research related to pharmaceutical pollution of water resources; describe health care treatments derived from marine life; and discuss suggestions for promoting aquatic health. They conclude that by taking care to preserve aquatic life, we contribute to the quality of our own human lives.
The Impact of Evidence-Based Practice in Nursing and the Next Big Ideas
Authors: Stevens Kathleen
Published: November 2021

The impact of evidence-based practice (EBP) has echoed across nursing practice, education, and science. The call for evidence-based quality improvement and healthcare transformation underscores the need for redesigning care that is effective, safe, and efficient. In line with multiple direction-setting recommendations from national experts, nurses have responded to launch initiatives that maximize the valuable contributions that nurses have made, can make, and will make, to fully deliver on the promise of EBP. Such initiatives include practice adoption; education and curricular realignment; model and theory development; scientific engagement in the new fields of research; and development of a national research network to study improvement. This article briefly describes the EBP movement and considers some of the impact of EBP on nursing practice, models and frameworks, education, and research. The article concludes with discussion of the next big ideas in EBP, based on two federal initiatives, and considers opportunities and challenges as EBP continues to support other exciting new thinking in healthcare.
Building Linkages between Nursing Care and Improved Patient Outcomes: The Role of Health Information Technology
Authors: Dykes Patricia , Collins Sarah
Published: November 2021

Health information technology (health IT or HIT) holds the potential to transform the quality of care and to establish linkages between nursing care and patient outcomes. This article defines eMeasurement and describes Quality of Care Definitions and Metrics for Evaluation. The authors explore the role of health IT to improve quality, barriers to eMeasurement, and health IT interventions by considering linkages between nursing care and patient outcomes for a select set of nursing sensitive indicators including patient falls, pressure ulcers, and the patient experience. We discuss specific challenges, such as barriers for routine data capture to populate nursing sensitive indicators and the use of health IT to promote positive outcomes. The conclusion addresses the implications of the current state of health IT and identifies areas for further nursing research.
Challenges in High Fidelity Simulation: Risk Sensitization and Outcome Measurement
Authors: Onello Rachel , Regan Mary
Published: November 2021

As the use of high fidelity simulation (HFS) in nursing education increases, evidence of its impact on learner self-confidence continues to grow. However, evidence to demonstrate an actual, positive influence on learner competence remains inconsistent. This lack of clear evidence supporting increased clinical competence challenges faculty seeking effective teaching strategies related to HFS. The purpose of this article is to discuss two key challenges in the integration and use of HFS in nursing curricula. The authors review the use of HFS in nursing education and provide a critical discussion of two challenges to incorporating HFS into the nursing curricula: the dangers of risk sensitization and the need for a standardized framework. They conclude that simulation experiences that encompass the element of longitudinal care and patient response, along with further research identifying best practices are needed to provide a sound basis for supporting the use of HFS in nursing education.
La rue bordée de boutiques au-dessus de l’Odéon de Lyon (Haut-Empire)
Authors: Fellague Djamila , Houal Jean-Baptiste , Olivero Davide , Papadopoulou Anna , Mignon Jean-Marc
Published: November 2021

L’article est consacré à la rue bordée de boutiques-ateliers visible au-dessus de l’odéon de Lyon. Un bilan historiographique est suivi d’une mise au point sur les caractéristiques des vestiges et sur leur chronologie, qui ne peut être fondée sur aucune stratigraphie. Cette présentation est l’occasion de s’arrêter sur une fontaine de rue ainsi que sur une construction inédite, de nature indéterminée, située devant un mur peint à pilastres. La chronologie avancée pour la fontaine a une incidence sur la restitution de la circulation des véhicules à l’échelle de la ville : elle affaiblit l’hypothèse de la condamnation de la rue carrossable après la construction de l’édifice de spectacle. Au contraire, c’est peut-être la volonté de la maintenir en usage qui a pu engendrer la suppression du lacus et des boutiques afin de réaliser, à peu de frais, un décalage de la rue et du portique.
Travail reproductif et parentalité
Authors: Gabaret Jim
Published: November 2021

Les théories féministes ont souvent critiqué l’essentialisme intrinsèque aux notions de « nature », de « naturel féminin ou masculin » et de « droit naturel ». Mais la notion de nature ne peut pas être si vite disqualifiée. Les luttes de reconnaissance du travail domestique, émotionnel et reproductif mobilisent ainsi implicitement un droit naturel du travail. Elles usent pour ce faire d’un concept de « travail » dont on critiquera l’application aux tâches d’enfantement ou de soin. Mais d’après certaines théories du care dont on étudiera les liens avec les sciences naturelles, c’est en admettant que ces tâches ne sont pas du travail, mais justement des activités « naturelles », d’une « nature » humaine qui concerne autant le masculin que le féminin, qu’on pourra participer à mieux les répartir.
La relation diplomatique entre la Chine et le Brunei : de multiples intérêts
Authors: Galloux Félix
Published: November 2021

Le sultanat de Brunei est certes un micro-État de par sa taille, mais il bénéficie d’importantes ressources en hydrocarbures, le faisant de ce fait un acteur important dans la géopolitique régionale. Bien que lié à la Chine, sa relation reste complexe avec Pékin pour un État vivant de sa rente pétrolière.
La semaine sanglante : une formule ?
Authors: Dontenwille-Gerbaud Aude
Published: November 2021

L’épisode tragique de la fin mai 1871 où les troupes républicaines versaillaises entrent dans Paris insurgé pour mettre fin à l’expérience de la Commune se nomme classiquement semaine sanglante . Cet article interroge le choix graphique d’emploi de majuscules, de minuscules et de guillemets dans l’écriture du syntagme. Dans une démarche en analyse du discours, l’historienne travaille un corpus hétérogène constitué de textes littéraires, d’ouvrages politiques, d’articles de presse ou encore d’analyses historiographiques couvrant la large période de mai 1871 à nos jours. Cette recherche exploratoire ne prétend en rien à l’exhaustivité et demande à être poursuivie, notamment par la constitution d’un corpus en langue anglaise.
$ S $-asymptotically $ \omega $-periodic dynamics in a fractional-order dual inertial neural networks with time-varying lags
Authors: Qu Huizhen ,   Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, China, Zhou Jianwen
Published: November 2021

This paper investigates global dynamics in fractional-order dual inertial neural networks with time lags. Firstly, according to some crucial features of Mittag-Leffler functions and Banach contracting mapping principle, the existence and uniqueness of $ S $-asymptotically $ \omega $-periodic oscillation of the model are gained. Secondly, by using the comparison principle and the stability criteria of delayed Caputo fractional-order differential equations, global asymptotical stability of the model is studied. In the end, the feasibility and effectiveness of the obtained conclusions are supported by two numerical examples. There are few papers focus on $ S $-asymptotically $ \omega $-periodic dynamics in fractional-order dual inertial neural networks with time-varying lags, apparently, the works in this paper fill some of the gaps.
Levenberg-Marquardt method for absolute value equation associated with second-order cone
Authors: Miao Xin-He , Yao Kai , Yang Ching-Yu , Chen Jein-Shan
Published: November 2021

In this paper, we suggest the Levenberg-Marquardt method with Armijo line search for solving absolute value equations associated with the second-order cone (SOCAVE for short), which is a generalization of the standard absolute value equation frequently discussed in the literature during the past decade. We analyze the convergence of the proposed algorithm. For numerical reports, we not only show the efficiency of the proposed method, but also present numerical comparison with smoothing Newton method. It indicates that the proposed algorithm could also be a good choice for solving the SOCAVE.
Measuring efficiency of a recycling production system with imprecise data
Authors: Hu Cheng-Feng , Wang Hsiao-Fan , Liu Tingyang
Published: November 2021

Resources scarcity and environmental degradation have made sustainable resource utilization and environmental protection worldwide. A circular economy system considers economic production activities as closed-loop feedback cycles in which resources are used sustainably and cyclically. Improving the eco-efficiency of the circular economy system has both theoretical value and practical meaning. In this work, the efficiency measurement model of the circular economy system with imprecise data based on network data envelopment analysis is proposed. The two-level mathematical programming approach is employed for measuring the system and process efficiencies. The lower and upper bounds of the efficiencies scores are calculated by transformed conventional one-level linear programs so that the existing solution methods can be applied. The proposed method is applied to assess the circular economy system of EU countries. Our results show that most countries have large difference among fuzzy efficiencies between the production efficiency and recycling efficiency stages, which reveals the source that causes the low efficiency of the circular economy system.
Optimality and duality for complex multi-objective programming
Authors: Huang Tone-Yau , Tanaka Tamaki
Published: November 2021

We consider a complex multi-objective programming problem (CMP). In order to establish the optimality conditions of problem (CMP), we introduce several properties of optimal efficient solutions and scalarization techniques. Furthermore, a certain parametric dual model is discussed, and their duality theorems are proved.