Engaging a polylactide copolymer in oral tissue regeneration: first validation of Suprathel® for guided epithelial and osseous healing
Authors: Vacaras Sergiu ,   Department of Maxillofacial Surgery and Radiology, Division of Maxillofacial Surgery and Implantology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania,   Department of Maxillofacial Surgery and Radiology, Division of Maxillofacial Surgery and Implantology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania,   Department of Maxillofacial Surgery and Radiology, Division of Maxillofacial Surgery and Implantology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania,   Department of Maxillofacial Surgery and Radiology, Division of Maxillofacial Surgery and Implantology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania,   Department of Maxillofacial Surgery and Radiology, Division of Maxillofacial Surgery and Implantology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania,   Department of Maxillofacial Surgery and Radiology, Division of Maxillofacial Surgery and Implantology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania,   Department of Maxillofacial Surgery and Radiology, Division of Maxillofacial Surgery and Implantology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania,   Department of Maxillofacial Surgery and Radiology, Division of Maxillofacial Surgery and Implantology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania,   Department of Maxillofacial Surgery and Radiology, Division of Maxillofacial Surgery and Implantology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania,   Department of Maxillofacial Surgery and Radiology, Division of Maxillofacial Surgery and Implantology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, Baciut Grigore , Gheban Dan ,   Department of Morphological Sciences, Division of Pathoanatomy, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, Bran Simion , Colosi Horatiu ,   Department of Medical Education, Division of Medical Informatics and Biostatistics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania,   *Corresponding Author: Horatiu Alexandru Colosi, Associate Professor, DMD, MS, PhD, Department of Medical Education, Division of Medical Informatics and Biostatistics, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 6 Louis Pasteur Street, 400349, Cluj-Napoca, Romania. Phone: +40264597256 Fax: +40264893547 E-mail: hcolosi@umfcluj.ro, Toader Septimiu ,   Center for Experimental Surgery, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, Opris Daiana , Kretschmer Winfried ,   Klinik fur Mund-, Kiefer- und Plastische Gesichtschirurgie, Alb Fils Kliniken GmbH, Goppingen, Baden-Wurttemberg, Germany, Manea Avram , Armencea Gabriel , Baciut Mihaela , Opris Horia , Mitre Ileana , Hedesiu Mihaela ,   Department of Maxillofacial Surgery and Radiology, Division of Maxillofacial Radiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania, Dinu Cristian 
Published: October 2021

The present study investigated the capacity of Suprathel® (a copolymer membrane, so far validated for skin regeneration) to also regenerate oral tissue – mucosa and bone, by comparing this biomaterial, in a split-mouth rabbit model, to Mucoderm®, a xenogeneic collagen matrix certified for keratinized oral mucosa healing. The clinical reason behind this experimental animal model was to determine whether the benefits of this advanced skin regeneration product (Suprathel®) could be conveyed for future evaluation in clinical trials of oral tissue regeneration in humans. The outcomes of this study validated the use of Suprathel®, a terpolymer of polylactide with trimethylene carbonate and ε-caprolactone, for stimulation of oral epithelium and alveolar bone regeneration in rabbits. Both Suprathel® and Mucoderm® exhibited comparable results and the null hypothesis stating a comparable regenerating effect of these two materials could not be rejected.