bluuebunny/crossref_metadata_2025 huggingface dataset:
Incorporación de los Objetivos de Desarrollo Sostenible en los planes de desarrollo municipales en el departamento del Huila
Authors: Bravo Rivera Yuly Vanesa
Published: February 2023

Uno de los mayores reconocimientos que ha tenido el departamento del Huila a nivel nacional e internacional es su producción agrícola, este es catalogado como uno de los departamentos más productivos del país. Sin embargo, su nivel productivo se ha visto opacado por la identificación de diferentes problemáticas ambientales, entre ellas las prácticas inadecuadas de producción, así como ha quedado evidenciado en diferentes informes, específicamente y para objeto de estudio dentro del plan de Desarrollo Departamental “El camino es la educación 2016-2019” y el Plan de Acción 2016- 2019 realizado por la Corporación del Alto Magdalena CAM. 

Para este análisis se realizó una investigación de carácter objetivo normativa con enfoque analítico descriptivo, puntualmente de la incorporación de los Objetivos de Desarrollo Sostenible dados desde la Organización de Naciones Unidas, en el marco de la regulación ambiental existente a nivel nacional, y específicamente un estudio a la particularidad del Departamento. Esto con el fin de determinar si la articulación realizada responde a las problemáticas demostradas en el sector ambiental en relación con el agrícola.  

El estudio encontró que, el mayor desarrollo en el tema de producción ambientalmente sostenible a nivel municipal, se encuentra reflejado en los programas y metas propuestas en los Planes de Desarrollo Municipales, los cuales se construyen siguiendo un modelo participativo dado por la metodología del Departamento Nacional de Planeación, esto es, articulado con el Plan Nacional de Desarrollo, Plan Departamental de Desarrollo y con los Objetivos de Desarrollo Sostenible. Estos últimos demostrados de manera característica y particular en cada municipio.
El conflicto armado y su impacto en los ecosistemas del Departamento del Huila: reflexiones de un proceso investigativo en tiempos de pandemia
Authors: Ordoñez Ardila María del Mar , Mosquera Jonathan Andrés , Amórtegui Cedeño Elías Francisco
Published: February 2023

En el presente artículo se expone una descripción narrativa y reflexiva acerca del proceso de aprendizaje, obtenido a partir de la convocatoria denominada Jóvenes investigadores e innovadores para el Departamento del Huila No.856, otorgado en el año 2019 en modalidad de beca-pasantía; la cual es desarrollada anualmente por el Departamento Administrativo de Ciencia, Tecnología e Innovación-Minciencias en el programa de oferta institucional, dirigido a estudiantes o graduados pertenecientes a grupos de investigación de las instituciones de educación superior o centros de desarrollo tecnológico.  

En ese sentido, se presenta la experiencia desarrollada bajo el marco de la beca-pasantía vinculada al grupo de investigación CPPC-Conocimiento Profesional del Profesor de Ciencias- Categoría A Minciencias, adscrito al programa de la Licenciatura en Ciencias Naturales y Educación Ambiental de la Universidad Surcolombiana, la cual fue realizada en el periodo de tiempo del 27 de marzo del año 2020 hasta el 10 de abril del año 2021, a través de la ejecución del proyecto de investigación titulado Concepciones del profesorado de Ciencias naturales y Educación ambiental sobre la repercusión del conflicto armado en los ecosistemas del departamento del Huila, en modalidad virtual debido a la emergencia mundial sanitaria por la covid-19, no obstante durante el desarrollo del proyecto se destaca que las tendencias investigativas han estado enfocadas principalmente en el reconocimiento de los escenarios del posconflicto desde las representaciones sociales, excluyendo en algunos casos la escuela como eje dinamizador del aprendizaje, por lo cual es importante reconocer las concepciones, emociones y actitudes de estudiantes y maestros sobre el fenómeno del conflicto armado y sus implicaciones en el actuar social y desarrollo ambiental.
La investigación como instrumento en el desarrollo y formación profesional
Authors: Rodríguez Quintero Ana María
Published: February 2023

Para la creación del artículo de revisión se brindaron espacios de formación en revisión y selección documental de artículos de investigación en temas de depresión y DCL en revistas indexadas, así como formación en la elaboración y publicación de artículos científicos, lo que derivó en el desarrollo de habilidades que permitieron iniciar un proceso de publicación de este trabajo en revistas de impacto e interés a nivel académico y social.
Pardos y morenos veracruzanos, siglo XVIII: blanquitud y diferencia colonial en las milicias novohispanas
Authors: Jiménez Sotero Jairo Eduardo
Published: February 2023

En el artículo pretendemos demostrar como las ideas de blanquitud y diferencia colonial se hicieron patentes durante la incorporación de los afrodescendientes novohispanos a los modelos defensivos de la Monarquía católica y como estos dos elementos condicionaron — pero no impidieron— el acceso de pardos y morenos a estos cuerpos. El escrito se compone de tres apartados en los que se utilizan estudios de caso provenientes de diversos archivos. Se comienza el texto presentando un contexto histórico de las milicias en el continente americano. Posteriormente se discuten las estrategias de blanqueamiento social utilizadas por los afrodescendientes para ingresar a las milicias y en el tercer y último apartado, se analiza la existencia de compañías milicianas de tipo independientes como un mecanismo más de acceso diferenciado para pardos y morenos a las fuerzas armadas novohispanas en el siglo XVIII. Cerraremos el articulo con un conjunto de reflexiones finales.
Aprendizajes sobre la enseñanza de la blanquedad en América Latina
Authors: Carlos Fregoso Gisela
Published: February 2023

En este artículo presentaré algunos de los hallazgos y reflexiones surgidas a partir de la investigación «Blanquedad en México. Hacia una comprensión de ser blanco en México para generar agendas de justicia social», adscrita a la Universidad de Guadalajara; dicha investigación se llevó a cabo durante el año 2020 y 2021. Parte de la metodología fue llevar a cabo dos seminarios desde México, cada seminario de seis meses, en donde participaron en total sesenta y tres ponentes y aproximadamente cien asistentes. Basada en los hallazgos de esta investigación, en este artículo sostengo la hipótesis de que las personas blancas y mestizas desean ser parte de las conversaciones antirracistas, pero desde posicionamientos binarios los cuales contribuyen a discusiones «blancos vs. no blancos». Para demostrarlo, primero mostraré algunas de las discusiones angloparlantes sobre los estudios de blanquedad, posteriormente mencionaré varios análisis clave sobre la blanquedad en América Latina que nos permitan hacer una distinción conceptual; en un tercer momento explicaré en qué consistió dicho seminario para luego desmenuzar las implicaciones que tienen las voces de personas blanco-mestizas en las conversaciones antirracistas. Finalizo el texto profundizando en dos ideas centrales como el negacionismo blanco-mestizo y las implicaciones de la educación de los cuerpos blancos en el antirracismo.
Vietnamese Higher Education Challenges: Quality Accreditation, Rankings and Ratings
Authors: Duc Nguyen Huu , Anh Tran Mai , Hien Ta Thi Thu
Published: February 2023

A study analyzing data from an international university ranking system, a regional rating system, and quality accreditation processes revealed that challenges of Vietnamese higher education are identified in three levels: the national system, the institution level, and training programs. Analysis of the multiple datasets exposed 20 potential gaps at the educational institution and training program level assessments, which may be the reasons preventing the top five ASEAN Vietnamese higher education to further advance to higher levels. On that basis, the report proposes eight solutions to improve the quality and competitiveness of the university accreditation, ranking and rating systems.
Krajowe miody odmianowe w profilaktyce i lecznictwie
Authors: Hołderna-Kędzia Elżbieta , Kędzia Bogdan
Published: February 2023

The paper presents the characteristics of domestic varietal honeys, taking into account their formation, organoleptic properties, and characteristic ingredients – the chemical markers, biological, prophylactic and therapeutic properties. Light honeys (rapeseed, acacia, multiflower) showed weak or medium level of biological activity, which is low antibiotic and enzymatic activity. Dark honeys, from high summer or late summer (linden, buckwheat, heather, honeydew) were characterized by a stronger biological effect, which translated into higher antibiotic and enzymatic activity.
Oddziaływanie olejku rozmarynowego (Rosmarini aetheroleum) na grzyby drożdżopodobne
Authors: Kędzia Anna , Hołderna-Kędzia Elżbieta
Published: February 2023

Introduction. The plants have been used as herbs and medicines for thousands of years. Rosemary (Rosmarinus officinalis L.) from Lamiaceae family is cultivated all over the world. The rosemary herb contains flavonoids, carnosic acid, caffeic acid and its esters (rosmarinic acid), referred to as Labiatae tannins, essential oil (borneol, 1,8-cineol, borneol acetate, ?- and ?-pinene, camphor, ?-myrcene, camphene, geraniol, citronellol, linalool, p-cymene, ?-terpinene, ?-phellandrene, verbenone) and phytosterols. The compounds present in the extracts and essential oil have antimicrobial, antioxidant, antitumor and antidiabetic properties, protect against gastric and duodenal ulcers and prevent dementia in the elderly peoples. Aim. The aim of the research was to determine the activity of rosemary oil (Semifarm, Gdańsk) against yeast-like fungi of the genus Candida. Material and methods. 31 strains of yeast-like fungi isolated from the oral cavity of patients with candidosis and 9 reference strains were tested. The susceptibility (MIC) was determined by the method of serial dilution in Sabouraud agar. The suspension containing 10 5 CFU/drop was transferred using a Steers apparatus upon the agar medium with the appropriate concentration of rosemary oil (15.0; 10.0; 7.5; 5.0 and 2.5 mg/ml) and on the medium without the addition of oil (strain growth control). Incubation was carried out for 24-48 hours in aerobic conditions at 37°C. The lowest concentration of rosemary oil, which completely inhibited the growth of the tested yeast-like fungi strains, was assumed as MIC. Results. The growth of all tested yeast-like strains was inhibited by oil concentrations of 7.5-15.0 mg/ml. The most sensitive to rosemary oil were strains of the species C. utilis (MIC = 7.5 mg/ml), C. guilliermondii and C. kefyr (MIC 7.5-10.0 mg/ml), and the least sensitive species were C. tropicalis. C. krusei and C. lusitaniae strains were more resistant (MIC = 15 mg/ml). Conclusions. Candida strains showed moderate sensitivity to rosemary oil. The oil was most active against yeast-like fungi strains from the species of C. utilis, C. guilliermondii and C. kefyr. The strains of C. krusei and C. lusitaniae showed the lowest sensitivity to the oil.
Aktywność przeciwutleniająca handlowych preparatów propolisowych
Authors: Cabaj Agnieszka , Juszczak Lesław
Published: February 2023

Introduction. Propolis is a resinous substance collected by honey bees Apis mellifera. Due to a significant content of compounds with varied biological activity, propolis shows a wide spectrum of antioxidant activity. Due to increasing interest in the use of propolis in prevention and treatment of many disease entities, the commercial offer of propolis-based preparations is constantly widening. However, the properties of such commercial propolis preparations can be very diverse, which is related both to the origin of the raw material itself as well as to its purification, processing and extraction of bioactive compounds. Aim. The aim of this study was to evaluate and compare antioxidant properties of commercial propolis preparations. Material and methods. Ten liquid commercial propolis preparations available on the Polish market from different producers constituted the material tested. The total content of phenolic compounds, flavonoids and phenolic acids was determined in the examined preparations. Moreover, their antioxidant activity, antiradical activity in reaction with ABTS•+, DPPH• and OH•, reducing ability by FRAP and CUPRAC methods and chelating ability of Fe (II) ions were evaluated. Results. The studied propolis preparations were characterized by different content of antioxidant compounds. The total content of polyphenols ranged from 4.62 to 215.03 mg GAE/ml, flavonoids from 0.49 to 21.26 mg QE/ml and phenolic acids from 1.16 to 28.81 mg CAE/ml. The content of antioxidant-like constituents determined the antioxidant and antiradical activities as well as the reducing and chelating capacity of the individual samples. There was also a significant linear correlation (r = 0.69) between the declared propolis concentration in the preparation and the total polyphenol content. Conclusions. The correlation between the content of polyphenols and antioxidant and antiradical activity as well as reducing and chelating ability was confirmed by significant values of linear correlation coefficients. It was stated that the concentration of propolis alone is not the only factor determining its antioxidant activity, which is confirmed by the lowest activity of a non-alcoholic preparation with a relatively high concentration declared by the manufacturer.
SPECYFIKA INFORMACJI MUZYCZNEJ I PROBLEMY WERBALNEJ REPREZENTACJI OBRAZÓW MUZYCZNYCH ZA POMOCĄ JĘZYKA
Authors: ЦЕНДРОВСКА Александра
Published: February 2023

W artykule podejmuje się problem reprezentacji muzycznej informacji przy pomocy środków języka. Stwierdzono, że ma on związek z opisem wrażeń o innym charakterze niż sam opisywany obiekt – z wrażeniami zmysłowymi, emocjonalnymi stanami, myślami i przejawem woli. Zauważono związek przyczynowo-skutkowy między obrazem świata odbiorcy, który jest z  jednej strony zawsze indywidualny i niepowtarzalny oraz kulturowo i cywilizacyjnie wspólny dla członków jednej wspólnoty, a różnicą w percepcji akustycznych przebiegów dźwiękowych, co bezsprzecznie ma przełożenie na interpretację przebiegów muzycznych. Autor postawia tezę o niewystarczalności środków językowych, gdzie mamy do czynienia z kodem jakościowo odmiennego typu (pojęciowo-werbalnym), przy czym jest to zawsze język narodowy, a także o pewnych ograniczeniach wynikających z umiejętności użytkownika języka.

W artykule omówiono kilka rodzajów dyskursu, zwrócono uwagę na to, że w związku z innym typem działalności językowej, w każdym z nich będzie inny cel podczas realizacji procesu werbalizacji informacji muzycznej. Określono problemy związane z typologizacją i opisem wrażeń muzycznych – brak wyjątkowych środków wyrazu, odrębnego słownictwa, które może opisywać muzykę jako fenomen, co prowadzi to tego, że opisywane są obiekty z muzyką styczne. Ponadto w opisie dochodzi do synkretycznego połączenia kwestii stanów sensorycznych i emocjonalnych. Autor pracy przeanalizował bazowe terminy muzyczne, które nie mówią wprost o fizycznym zjawisku dźwiękowym, lecz o pojęciach z obszaru informacji o muzyce jako rodzaju sztuki, jako doświadczeniu kulturowym, oraz jako sferze przeżyć emocjonalno-akustycznych. Obiekty te (muzyka jako tekst, muzyka jako utwór, muzyka jako sztuka) mieszczą się w jednej przestrzeni kognitywnej, jednak mają odmienny status ontologiczny, semantyczny i pragmatyczny.

Narracja i deliberacja zostały określone jako podstawowe sposoby werbalnej prezentacji wrażeń muzycznych, demonstracja zaś jako najbardziej adekwatna możliwość zobrazowania samego ciągu muzycznego.
PRAGMATICS OF THE INITIATION NOVEL
Authors: ГАРАСИМ Тетяна
Published: February 2023

A type of literature that is intended for teenagers and young adults is the novel of initiation, which is a narrative about maturation, the process of growing up, the loss of innocence and the entry into the stage adulthood. These texts form a separate phenomenon of literature, which acts as a kind of “bridge” from children’s to adult reading and is characterized by a number of psychological characteristics, worldview aspects, a peculiar system of images and motives, themes, aimed at readers of adolescence.

Modern literature turns to the ritual, borrowing certain elements of its structure and aesthetically interpreting them in a literary text. Initiation rites are intended to transfer an individual to another social and spiritual status, i.e. socialization, and therefore they are directly related to various rites of passage. Through the prism of cultural experience, an individual searches for his own outlook and value orientations, which will help him understand himself, the world around him, and his place in it. It is the initiation rite that is the tool for a young person helping to become a full-fledged member of society, performs certain roles.

“Fusion of horizons” (term of H.R. Jauss) of the reading audience with the artistic content of modern literature implies that during reading the reader’s life situations are identified with the circumstances of the initiation rite of the heroes in initiation novels. This process makes possible a kind of initiation of the recipients of the texts, the result of which is an understanding of the modern social cultural situation, finding answers to questions about the meaning of human existence, gaining experience. In this sense, the reading process has an anthropological meaning, as it satisfies young people’s psychological needs for self-awareness, self-affirmation and self-realization in modern world. This is what defines the pragmatics of initiation novels.
РОМАН БОРИСА ХАРЧУКА «КРЕВНЯКИ» У РОСІЙСЬКОМУ ПЕРЕКЛАДІ
Authors: ГЛОТОВ Олександр
Published: February 2023

Роль російського перекладу творів радянських письменників національних республік у формуванні соціально-політичного статусу автора в ідеологічній структурі СРСР була надзвичайно високою. Наявність такого явища, поряд з фактом членства у Спілці радянських письменників, засвідчувала офіційне визнання автора, його право на відповідні пільги. Романи, повісті та оповідання українського прозаїка Бориса Харчука неодноразово перекладалися на європейські мови (англійську, німецьку, іспанську, польську, угорську) та мови народів Радянського Союзу (білоруську, вірменську, таджицьку), але перш за все – на російську. Творча та соціально політична біографія письменника складалася неоднозначно, репутація автора у читацькій рецепції досі не відповідає об’єктивній естетичній та громадській цінності його творів. Один з останніх творів літератора, роман «Кревняки», був виданий у російському перекладі 1987 року, ювілейного для радянської влади, року століття Жовтневого перевороту. Цей фактор очевидно від’ємно вплинув на естетичну якість перекладу, здійсненого В. Россельсом. Рельєфність, глибина та поетичне напруження оригінального українського тексту не знайшли адекватного відповідника у російськомовній версії. Причиною цього була від самого початку хибна методика перекладу художнього на основі перекладу підрядкового, без належного знання мови оригіналу. Загальносоюзний читач так і не зрозумів своєрідності художнього світу українського епіка, залишившись під нав’язаним впливом трактування у дусі ідей соціалістичного реалізму. Фактично переклад на російську мову творів українського прозаїка Бориса Харчука значною мірою дискримінував естетичну та соціальну вартість його творчої спадщини у сучасному художньо-соціальному сприйнятті, де письменник перебуває у лавах численних регіональних літераторів, зокрема волинських.
ЛІТЕРАТУРНО-МИСТЕЦЬКІ ЧАСОПИСИ ТЕРНОПІЛЛЯ КІНЦЯ ХІХ — ПЕРШОЇ ТРЕТИНИ ХХ СТОЛІТТЯ
Authors: РЕШЕТУХА Тетяна
Published: February 2023

У статті окреслюється цілісна картина становлення та функціонування літературно-мистецьких часописів Тернопілля кінця ХІХ – першої третині ХХ століття, з’ясувється їх змістове наповнення і тематичне спрямування.

Зазначається, що уже перший українськомовний часописом краю – рукописна газета членів учнівського товариства «Громада» «Сніп» (1876) – мала риси літературного часопису. Наголошується, що усі рукописні літературно-мистецькі часописи («Поступ», (Бережани); «Ідея», «Перший промінь», «Праця» (Тернопіль); «Перші кроки», «Юнацтво», «Хвиля», «Проліски» (Кременець)) видавалися учнями гімназій. Перші чотири датуються періодом Австро-Угорського панування, кременецькі видання – 20-ми роками міжвоєнного періоду. Вони містили художні твори (поетичні та прозові) в першу чергу самих гімназистів, а також українських письменників і поетів, а також статті національно-патріотичного та літературознавчого змісту. Видання відзначалися невеликим обсягом, обмеженою читацькою аудиторією і нетривали періодом існування – зазвичай вдавалося видати кілька чисел. Окремі видання («Ідея», «Перший промінь», «Юнацтво») тиражувалися на гектографі.

Друковані літературно-мистецькі часописи краю («Молодїж», «Чар-зілля», «Літературно-науковий вістник», «Сяйво» (Тернопіль), «Віра» (Кременець)) характеризуються широкою автурою, високим рівнем опублікованих у них творів. Два з п’яти видань («Чар-зілля» та «Літературно-науковий вістник») не були власне тернопільським, а їх редакції передислокувалися у місто зі Львова через помірну ціну на друкарські послуги.

Літературно-мистецькі видання Тернопільщини кінця ХІХ – першої третини ХХ століття були покликані до життя щораз більшою потребою в українському слові як реальному чинникові суспільного поступу нації, гуртуванням українців, піднесенням рівня їхньої національної свідомості. Вони видавалися з приватної ініціативи їх засновників – тодішніш чи майбутніх видатних постатей, громадських та культурних діячів України чи краю.
WOKALIZY WERBALNE INFORMACJI MUZYCZNEJ JAKO PRZYKŁAD IMITACJI SENSORYCZNO-EMOCJONALNEJ
Authors: ЦЕНДРОВСКА Александра , CZAJKOWSKI Piotr
Published: February 2023

W artykule omówiono jeden ze sposobów werbalizacji informacji muzycznej, mianowicie tzw. wokalizy werbalne. Na materiale tekstów w polskim, ukraińskim chorwackim i rosyjskim języku zastały zróżnicowane wokalizy proste i złożone kreowane, w odróżnieniu od wokaliz muzycznych, przez zwykłych słuchaczy w celu wyrażenia muzycznych wyobrażeń akustyczno-emocjonalnych. Autorzy artykułu zwracają uwagę na złożoność problemu. Stwierdzono potrzebę zbadania tej części informacji, wchodzącej w skład ludzkiego obrazu świata, która jeszcze nie została skonceptualizowana za pomocą pojęć, czyli tzw. treści niepojęciowych. Chodzi przede wszystkim o treści percepcyjne oraz emocjonalne. Jednostki, które takie treści wyrażają zostały określone jako ekspresywy werbalne. Nie nazywają one pojęć o obiektach myślenia, lecz wyrażają wyobrażenia psychiczne o takich obiektach oraz demonstrują je przy pomocy zabiegu imitacji. Wyróżniono zatem trzy rodzaje werbalizacji informacji kognitywnych o muzyce: nominacje (kiedy dochodzi do nazywania pojęć związanych z muzyką za pomocą słów, frazemów i frazeologizmów), predykację (kiedy ludzie poprzez zdania i teksty opisują  muzykę, oceniają ją, a także opowiadają lub rozważają o swoim przeżywaniu muzyki) oraz ekspresję samych wrażeń muzycznych przy pomocy ideofonów emocjonalnych (w tym przypadku dochodzi do imitacji dźwięków muzycznych poprzez demonstrację swoich wyobrażeń emocjonalno-akustycznych). W artykule krótko omówiono charakter wrażeń akustycznych jako jednego z obiektów informacyjnego doświadczenia zmysłowego, związanego z ostatnim obiektem z triady w działalności muzycznej (muzyka – sztuka, muzyka – utwór, muzyka – tekst), a także podkreślono istotną rolę w procesie odbioru muzyki stanów emocjonalnych, które bezpośrednio oddziałują na sferę doświadczenia związanego z przeżyciem piękna. W artykule zaprezentowano kilkadziesiąt egzemplifikacji ekspresji werbalnej, będących środkami celowej imitacji sensoryczno-emocjonalnej ciągów muzycznych oraz służących potoczno-estetycznej demonstracji wyobrażeń akustyczno-emocjonalnych.
КУЛЬТУРНИЙ ТРАНСФЕР І АНТРОПОЛОГІЧНИЙ ВИМІР УКРАЇНСЬКОЇ ПРОЗИ ПЕРШОЇ ПОЛОВИНИ ХІХ СТОЛІТТЯ
Authors: ПОПЛАВСЬКА Наталія
Published: February 2023

Рецензія на монографію Артура Малиновського «Антропологія української прози першої половини XIX століття. Культурні трансфери» (Київ: Талком, 2022. 560 с.).
Attitude Motion of Cylinder in Variable Electrostatic Field Near L1 Libration Point
Authors: Aslanov Vladimir S.
Published: February 2023

This paper explores the spatial attitude motion of an electrostatic cylindrical container (E container) in a variable attracting electrostatic field. This field generated by the E container and the orbiting spacecraft (orbiter) located at the L1 libration point of the Mars–Phobos system is used to capture the E container by the orbiter in the Phobos Sample Return mission. Based on the Lagrange formalism and using the Euler angles, the equations of attitude motion of a cylindrical E container are constructed in the framework of the circular restricted three-body problem with the addition of the electrostatic force and torque acting on the E container. For modeling electrostatic force and torque acting on a cylindrical E container, the multisphere method is used, which was developed by Stevenson and Schaub (Multi-Sphere Method for Modeling Electrostatic Forces and Torques,” Advances in Space Research, Vol. 51, No. 1, 2013, pp. 10–20). The influence of gravitational, centrifugal, and electrostatic moments on angular motion for different initial conditions has been studied analytically by analyzing the equations of both attitude motion and numerical simulations. It is shown that the action of the aforementioned torques as the E container approaches the orbiter causes the excitation of high-frequency nutation oscillations with large amplitudes. On the other hand, there are no natural and artificial factors of physical nature that could lead to damping of oscillations of large amplitude, and this fact corresponds to the obtained equations of attitude motion. Also, the electrostatic torque is the greatest contributor to the oscillations with large amplitude. Hence, it is clear that the E container must have a spherical current-conducting shell: in which case, the electrostatic torque turns to zero.
Overcoming Challenges of Polymer Injection Pilot in High-viscosity, High-salinity Reservoir – A Case Study from Sirikit Oilfield, Thailand
Authors: Worawutthichanyakul Thanawut , Hanchaiphiboolkul Suwapich , Ketmalee Thanapong , Pancharoen Monrawee , Sinhabaedya Prangtip , Thammasanya Rungkarn , Rujipimolkit Chuthanart , Srisuriyon Jantakan , Roatkanjanaporn Tiam , Sornsoongnoen Yannavit , Srisen Parichat
Published: February 2023

In Pru Kratium (PKM) highly viscous oil reservoir, the secondary recovery method such as waterflood can adversely affect production due to an unfavorable mobility ratio, resulting in viscous fingering and early water breakthrough. Although polymer flooding which usually mitigates unfavorable mobility ratio, this technique also faces a challenge due to the high salinity formation water which may lead to excessive polymer consumption. To improve recovery, a special polymer injection scheme was designed and the small-scale pilot was initiated.

After one year of injection, the pilot demonstrated that the polymer improved the sweep efficiency of the flood in both vertical and horizontal directions. Ultimately, the increase in oil recovery factor gain was 2.41%.
Formulation, Statistical Optimization and Stability Study of Ondansetron Films
Authors: Thakare Mahesh M. , Karole Sarita .
Published: February 2023

Nausea and/or vomiting is common in patients of all ages. Nausea and vomiting can occur for a variety of reasons and may be related to illness or treatment. Careful study of the receptors involved has aided in the selection of drug classes to treat patients (34). This study aimed to prescribe an oral dissolving film of the antiemetic drug ondansetron for treating vomiting patients and nausea and vomiting (NVP) in pregnancy. The goal for optimizing the orally dissolving ondansetron film was to reduce disintegration time and maximize drug release from the film. The formulation of the mouth-dissolving film contains carefully selected additives to impart aesthetic and performance properties such as taste masking, rapid dissolution, physical mouth feel and tactility. From a regulatory perspective, all excipients used in the formulation of oral dissolution films are generally considered safe (i.e., on the GRAS list ) and are approved for use in oral pharmaceutical dosage forms.
Extraction, Characterization and Therapeutic Evaluation of Seeds of Phaseolus vulgaris L. for Weight Management
Authors: Bhide Yogesh S. , Nehete Jitendra Y. , Bhambar Rajendra S.
Published: February 2023

The frequency of overweight concerns and obesity is progressively growing in high-income countries in the west and low-income and middle-income countries. Those suffering from these conditions may find that taking measures to cut their carbohydrate consumption and their absorption rate is beneficial. To slow the pace at which glucose is taken into the bloodstream, blocking amylase, a key enzyme in the digestion of carbs, is highly recommended. AIs, or beta-amylase inhibitors, are chemicals found in plants that work to prevent this enzyme from doing its job. Interestingly, the common bean, or Phaseolus vulgaris, has protein-based α‐Amylase inhibitors that regulate the activity of this enzyme through protein-protein interaction. In this article, we cover the numerous extracts of common bean seeds, the protein inhibitors that those extracts include, and what the most recent research has shown about the molecular structure of those extracts and the method by which they exert their inhibitory effects. Evidence for the possible benefits of P. vulgaris protein inhibitors, including clinical research conducted on both animals and humans, is also covered in this article. However, more research is necessary to validate the therapeutic efficacy of the drugs already on the market. This research has the ability to provide a succinct review of the current state of information on P. vulgaris extract and its prospective application as a nutraceutical alternative to control possible weight gain if observed to be successful.
Preparation, Characterization of Bacterial Cellulose and
Chlordiazepoxide Tablets for Oral Drug Delivery
Authors: Kodalkar Dada . , Kulkarni Ajit . , Shrivastav Birendra . , Tare Harshal .
Published: February 2023

Bacterial cellulose (BC) is a highly purified form of cellulose that offers several benefits, including an ultrafine fiber network, a high water retention capacity, and simple fabrication into desired forms. There has been a recent uptick in BC’s focus on drug delivery for biomedical applications. Studies on prodrug design, controlled-release methods, and pill coating have all been conducted for BC. This research was done to determine if BC might be employed as a medication carrier in chemical and biological formulations. BC microparticles laden with the medication were produced via grinding. Clordiazepoxide hydrochloride (CDP) was used to test the microparticles’ drug loading and release capabilities. Particle morphologies, drug loading efficiency, loaded drug physical state, and drug release behavior were all assessed for the manufactured microparticles. Amorphous microparticles were formed from BC microparticles. An scanning electron microscope (SEM) study found that the microparticles had a nearly round form with an average diameter of 400–500 μm. Drug loading was greater in the renewed BC microparticles (37.57 ± 0.22%) when the concentration of drugs was held constant at 10%. More than 85% of the medication was delivered for all formulations in the first 30 minutes.
Estimation of Linoleic Acid in Flax Seed Oil Formulation using a Validated High-performance Thin-layer Chromatograph Method
Authors: Kothapalli Lata . , Tupe Rahul . , Thomas Asha . , Raut Vaidehi .
Published: February 2023

Linoleic acid, an omega-6 fatty acid present widely in plant seeds and one of the major components among the fatty acids in Linum Usitatissimum L., commonly called as flax seed and represents the content of 12–19% out of the total lipids in flax seed. This work attempted to quantify the Linoleic acid from flax seed oil using the high-performance thin layer chromatography (HPTLC) method with mobile phase, methanol: toluene: formic acid (3:7:1 v/v), and the wavelength used is 254 nm. The method gave a sharp, symmetrical peak at Rf value 0.63 ± 0.02. The method was validated using intracerebral brain hemorrhage (ICH) guidelines and applied to the assay of marketed capsules of flaxseed. It is confirmed that the reported method can help analyze flax seed oil in different dosage forms, along with cosmetic products containing linoleic acid-rich oils.
An Improved Efficient Chromatographic Development and Validation for Quantitative Determination of Rosuvastatin Calcium and Cholecalciferol in Solid Pharmaceutical Tablets Dosage Forms
Authors: Jana Kallol . , Mahanti Beduin .
Published: February 2023

The simple, reliable, sensitive and isocratic analytical chromatography was developed for the estimation, separation and validation of both the drugs rosuvastatin calcium and cholecalciferol in tablets dosage forms. Chromatographic elution was attained by C18 thermo, 250 x 4.6 mm column, with particle size 5 μm and 1.5 mL per minute flow rate using mobile phase as methanol : acetonitrile : triethanolamine (55:45:0.4%). Detection of both drugs were monitored at 265 nm. The retention time of rosuvastatin calcium and cholecalciferol were 1.336 and 6.031 minutes, respectively and overall chromatographic run time was approximately 20 minutes. The establishment of linearity was done in concentration of 70–130 μg/mL ( r2 = 0.995) and 7–13 IU ( r2 = 0.983), respectively in rosuvastatin calcium and cholecalciferol. The limit of detection (LoD) 0.88 and 0.11 and limit of quantification (LoQ) was 2.66 and 0.34 for rosuvastatin calcium and cholecalciferol, respectively. Accuracy (recovery) was between 94.34 to 103.51% and 100.82 to 102.46% for rosuvastatin calcium and cholecalciferol, respectively. The developed and validated chromatographic method was within the acceptable limits for both the drugs with precision, robustness, accuracy, ruggedness, and stability of the solution and the relative standard deviation was less then 2. The proposed chromatographic method is precise, accurate, rapid, time effective, simple, reproducible for routine quantitative estimation of both the drugs rosuvastatin calcium and cholecalciferol in solid pharmaceutical tablets dosage forms
Formulation and Characterization of Herbal Ingredients based Shampoo
Authors: Kaushik Vivek . , Meel Rakesh K.
Published: February 2023

Shampoo is one of the cosmetic items that uses surfactants as its principal ingredient. When used as directed, the shampoo will clean the hair of surface grease, filth, and skin debris without having an unfavorable effect on the user. Shampoo is now used to promote hair growth and stop hair loss in addition to cleaning debris from the hair and scalp. The shampoo was prepared using amla extract, ritha extract, shikakai extract, bhringraja extract, henna extract, neem extract, and kalonji extract and evaluated for pH, wetting time, doaming properties, detergency ability, surface tension measurement, viscosity percent of solids, skin irritation test and stability test. It was concluded that sodium lauryl sulfate is very toxic to the hair. It damages the morphological integrity of the hair fiber, whereas natural conditioners protect hair morphological integrity and provides consistency and shine to hair.
The Impact of Generic Drug User Fee Act on Generic Drug
Export from India
Authors: Singh Rajender . , Singh Swati . , Kumar Anil . , Kulkarni GT . , Thakkar Arti .
Published: February 2023

Generic drugs are drugs that have a similar active ingredient, dosage type, strength, and route of administration as a brand name medication. India is the hub of generic drugs and exports to various countries. The regulations for generics have been evolving through the years for better control of the price and quality of generic drugs. In this study, we have formulated a questionnaire consisting of questions on review time, communication with authority, the quality of products, and future expectations of the industry. Most people agreed that there had been a change since the introduction of generic drug user fee act (GDUFA). It has helped in reducing the review time of backlog applications, quick review for new applications, and raised certain expectations from the industry for the future of GDUFA. Communication has also improved between the industry and the food and drug administration (FDA), which has helped the applicant better understand the expectation of the authority.
Exosomes as Crucial Player in Insulin Resistance and Obesity: Potential Therapeutic Approach
Authors: Sood Shreya , Devi Sushma , Singh Thakur G , Yadav Nishant , Kumar Parveen , Chatterjee Arindam
Published: February 2023

Increasing obesity has become a serious health problem worldwide in recent years, both in adults and children. Obesity can lead to numerous diseases such as osteoarthritis, diabetes, cardiovascular and respiratory diseases, and other metabolic disorders. In addition, obesity is considered one of the most common causes of insulin resistance in the body. Moreover, obesity disrupts normal insulin physiology, resulting in impaired insulin signaling and other intrinsic abnormalities such as poor glucose movement, phosphorylation, and decreased glucose oxidation and glycogenesis. Therefore, it is necessary to find an effective treatment for such conditions. Recently, exosomal therapy has been proposed as one of the alternative approaches to treat metabolic diseases. Exosomes are endosome-derived extracellular vesicles that circulate in body fluids such as mucus, blood plasma, urea, etc., transfer molecules and signals from one cell to another, and thus are involved in various normal and pathological processes in the human body. It has been discovered that exosomes play a role in processes related to obesity, such as adipocyte differentiation, angiogenesis, inflammation, etc. The current study reviewed exosomes’ role in the development of insulin resistance associated with obesity and possible targets.
Distribution and Biochemical Composition of Seaweeds in relation to Hydro-chemical Characters of Marine Water
Authors: Goswami Nirali Y. , Kumar Nirmal J.I. , Kumar Rita N. , Shah Riya
Published: February 2023

The aim of this study was to determine the distribution pattern, pigments and biochemical composition of various seaweed species collected from the Gopnath coast in Gujarat, India from August 2021 to December 2021 as well as to examine physico-chemical variables in marine waters. Besides, the relationship between the pigment, biochemical content of seaweed species and hydrochemical characters was also investigated with principal component analysis (PCA). There are total of nine species with the highest number of Chlorophyta species. During the investigation period, the distribution and occurrence of the species changed greatly. Results indicate that the chlorophyta had the highest chlorophyll content, on the other hand carotenoids were found greater in Rhodophyta members. According to a statistical analysis (Correlation) computed among environmental parameters and pigment, it was observed that the chlorophyll content was positively correlated with pH, salinity and hardness whereas carotenoid shows positive correlation with temperature and dissolved oxygen of selected site. Moreover, the principal component analysis shows that the pH, electrical conductivity (EC), salinity, hardness and alkalinity are the main factor for marine water quality whereas principal component analysis of metabolites of seaweed shows that the carbohydrate and amino acids are the main principal components of Chlorophyta species. Protein is the main principal component of Rhodophyta specie. Based on the results obtained, we can conclude that the hydro-chemical characters may play a role in the biosynthetic pathways of seaweed.
Study on Activated Carbon derived from Cassava Peels as Magnetic Solid of Dispersive Solid Phase Extraction Technique for Determination of Tetracycline
Authors: Rinawati R. , Kiswandono A.K. , Widiarto S. , Kasih Y.O. , Hadi S.
Published: February 2023

Concern on the existence of antibiotic residues in aqueous environment has been growing in recent years since they are known to impart various severe effects on human health and environment. In general, the concentration of antibiotic residue in environment is in trace level and often below the limit of detection of analytical instruments, implying that sample preparation prior to analysis requires particular strategy. In the present work, activated carbon produced from cassava peel was converted into magnetite activated carbon followed by utilization of magnetite activated carbon produced as adsorbent for tetracycline antibiotic, in order to evaluate its potential as the material for dispersive solid‐phase extraction (DSPE).Characteristics of the adsorbent were investigated using several techniques including Scanning electron microscopy (SEM) and X‐ray diffraction. Several parameters influencing the adsorption by DSPE were optimized. The tetracycline adsorbed by magnetic activated carbon was analyzed using a UV-Vis spectrophotometer at a wavelength of 275 nm. Characterizations revealed that the adsorbent has irregular surface, rough and highly porous structure with magnetic properties. Adsorption experiments indicate that equilibrium reached at pH 6, time 10 minute and adsorbate concentration 1 mg/L. By application of 20 mg adsorbent, the highest percentage of adsorption of 73 was achieved. The study indicates that magnetic activated carbon from cassava peel has promising potential as a low-cost and effective adsorbent for determination of tetracycline residues in aquatic environment.
Synthesis and characterization of phytochemical fabricated Ag doped ZnO nanoparticles with Ficus benghalensis and their enhanced antibacterial and photocatalytic applications
Authors: Gowri Shankari C. , Kavitha B. , Kalanithi M.
Published: February 2023

The use of various plant materials for the bio synthesis of metal oxide nanoparticles follows the principles of green chemistry since it minimizes the amount of chemicals used. In the present work, ZnO and Ag doped ZnO nanoparticles were synthesized utilizing aqueous leaf extract of Ficus benghalensis. The aqueous leaf extract was screened qualitatively for the presence of chemical constituents. The nanoparticles ZnO, green modified ZnO and Ag doped ZnO were characterized by X-ray diffraction (XRD), FT-IR, EDAX and Scanning Electron Microscope (SEM). The optical properties were studied using UV-Vis-DRS spectroscopy and a bathochromic shift is observed in the band gap energy of synthesized Ag doped ZnO. From XRD, the particle size of the ZnO, green modified ZnO and Ag doped ZnO nanoparticles was found to be 36, 39 and 53 nm respectively. Photodegradation of crystal violet dye was studied by UV-Visible spectroscopy. The degradation ability of the surface modified ZnO was found to be more efficient than that of bare ZnO and green modified ZnO nanoparticles. The photocatalytic reactions obeyed pseudo-first-order kinetics according to Langmuir- Hinshelwood model. The reuse of nanoparticles for photocatalytic activity was also studied.
Irreversible Inactivation of SARS-CoV-2 by Lectin Engagement with Two Glycan Clusters on the Spike Protein
Authors: Nangarlia Aakansha , Hassen Farah Fazloon , Canziani Gabriela , Bandi Praneeta , Talukder Choya , Zhang Fengwen , Krauth Douglas , Gary Ebony , Weiner David , Bieniasz Paul , Navas-Martin Sonia , O'Keefe Barry , Ang Charles , Chaiken Irwin
Published: February 2023

Host cell infection by SARS-CoV-2, similar to that by HIV-1, is driven by a conformationally metastable and highly glycosylated surface entry protein complex, and infection by these viruses has been shown to be inhibited by the mannose-specific lectins Cyanovirin-N (CV-N) and Griffithsin (GRFT). We discovered in this study that CV-N and His6-tagged GRFT not only inhibit SARS-CoV-2 infection but also lead to irreversibly inactivated pseudovirus particles. The irreversibility effect was revealed by the observation that pseudoviruses first treated with either CV-N or GRFT and then washed to remove all soluble lectin did not recover infectivity. Infection inhibition of SARS-CoV-2 pseudovirus mutants with single-site glycan mutations in Spike suggested that two glycan clusters in S1 are important for both CV-N and GRFT inhibition, one cluster associated with the RBD (receptor binding domain) and the second with the S1/S2 cleavage site. We observed lectin antiviral effects with several SARS-CoV-2 pseudovirus variants, including the recently emerged omicron, as well as a fully infectious coronavirus, therein reflecting the breadth of lectin antiviral function and the potential for pan-coronavirus inactivation. Mechanistically, observations made in this work indicate that multivalent lectin interaction with S1 glycans is likely a driver of the lectin infection inhibition and irreversible inactivation effect and suggest the possibility that lectin inactivation is caused by an irreversible conformational effect on Spike. Overall, lectins' irreversible inactivation of SARS-CoV-2, taken with their breadth of function, reflects the therapeutic potential of multivalent lectins targeting the vulnerable metastable Spike before host cell encounter.
Achieving Tunable Organic Afterglow and UV Irradiation-Responsive Ultralong Room-Temperature Phosphorescence from Pyridine-Substituted Triphenylamine Derivatives
Authors: Xiong Shengde , Xiong Yu , Wang Deliang , Pan Yiwen , Chen Keyao , Zhao Zheng , Wang Dong , Tang Ben Zhong
Published: February 2023

Amorphous polymers with ultralong room-temperature phosphorescence (RTP) have received considerable attention due to their potential applications in anti-counterfeiting, bioimaging, and sensing. However, multifunctional polymer-based RTP materials endowed with color-tunability or stimulus-responsiveness are highly desirable but rarely reported. Herein, we have designed three pyridine-substituted triphenylamine derivatives and achieved ultralong RTP properties with both color-tunability and UV irradiation-responsiveness by embedding them into poly(vinyl alcohol) (PVA) and poly(methyl methacrylate) (PMMA) matrices, respectively. Notably, introducing the pyridine groups with the capabilities of promoting intersystem crossing (ISC) and forming hydrogen-bonding networks is essential for triggering efficient and ultralong RTP from doping PVA systems. Consequently, doping film TPA-2Py@PVA exhibits excellent RTP property with an ultralong lifetime of 798.4 ms and a high quantum yield of 15.2%. Moreover, by co-doping with the fluorescent dye rhodamine B, color-tunable persistent luminescence has been realized via phosphorescence energy transfer. More importantly, doping PMMA systems exhibit reversible UV irradiation-responsive ultralong RTP properties. Finally, various patterns are devised to demonstrate the potential applications of these doping PVA and PMMA systems in advanced anti-counterfeiting and information encryption. We believe this feasible and facile strategy to achieve multifunctional organic RTP materials with color-tunability and stimulus-responsiveness will provide new opportunities for high-tech applications.