bluuebunny/crossref_metadata_2025 huggingface dataset:
A fluorescent probe for Hg 2+ specific recognition based on xanthene and its application in food detection and cell imaging
Authors: Zhang Chenglu , Nie Shiru , Liu Chang , zhang Yang , Guo Jinghao
Published: March 2024

The mercury-loving unit aminothiourea was introduced into the xanthene fluorophore to synthesized the probe molecule NXH. NXH has a specific response to Hg2+, and with the addition of (0 ~ 50 µM) Hg2+, the fluorescence intensity of the probe solution was quenched from 2352 a.u. to about 308 a.u.. The probe NXH exhibited excellent detection performance of high sensitivity (LOD = 96.3 nM), real-time response (105 s), wide pH range (2.1 ~ 9.3), and strong anti-interference ability for Hg2+. At the same time, the probe NXH has wide range of applications for Hg2+ detection, which can be used to create molecular logic gates, make Hg2+ detection test paper, as well as the fluorescence imaging of Hg2+ in Hela live cells and tea samples.
Comparative Analysis of Machine Learning Algorithms for Predicting House Prices
Authors: Yamannage Sachith Nimesh
Published: March 2024

This study conducted a thorough examination of residential property data in the Abbotsford area of M elbourne with the goal of identifying significant trends in housing, regional patterns, and variables aff ecting home values.The dataset contained a number of elements, such as neighborhood information, g eographic coordinates, transaction details, and property attributes.Using a variety of techniques, inclu ding mean imputation, forward filled imputation, machine learning algorithms, and discarding missin g data, the study started with the identification and treatment of missing values.Particularly in the pric e variable, outliers were found, and boxplots and other visualization tools were used for outlier analysi s.For additional analysis, numerical values representing the categorical variables were converted.To in vestigate the distributions of numerical variables and comprehend connections between variables with a focus on correlations with home prices—univariate and bivariate analyses were carried out. Feature engineering, covariance analysis, ANOVA testing, and predictive modeling with regression algorithms like Random Forest, XGBoost, and Support Vector Machine (SVM) were all part of the quantitative analysis process. Metrics like Mean Absolute Error (MAE) were used to assess the performance of the model; the results showed that XGBoost was the most accurate predictor of housing prices. Significant factors influencing home prices were identified by the study, such as building area, property type, number of rooms, and geographic considerations including proximity to important sites. Each component was analyzed in terms of its relative relevance, and the building area and land size. It was noted how the constructed model has limits, such as overfitting and the need for more model refining. The results offer insightful information to scholars, politicians, and real estate professionals who are interested in the dynamics of the housing market.
High-sensitivity whole-mount in situ hybridization of mouse oocytes and embryos visualizes the super-resolution structures and distributions of mRNA molecules
Authors: Sanada Takahiro , Kotani Tomoya
Published: March 2024

Background
Mammalian oocytes accumulate more than ten thousand mRNAs, of which three to four thousand mRNAs are translationally repressed. The timings and sites of translational activation of these dormant mRNAs are crucial for promoting oocyte maturation and embryonic development. How these mRNAs are accumulated and distributed in oocytes is therefore a fundamental issue to be explored. A method that enables visualization of mRNA molecules with high resolution in a simple manner would be valuable for understanding how oocytes accumulate and regulate the dormant mRNAs.
Results
We have developed a highly sensitive whole-mount in situ hybridization method using in vitro-synthesized RNA probes and the tyramide signal amplification (TSA) system optimized for mouse oocytes and embryos. Using this method, Pou5f1/Oct4, Emi2, and cyclin B1 mRNAs were detected in immature oocytes and 2-cell stage embryos. Confocal microscopy showed that these mRNAs formed granular structures in the oocyte cytoplasm. The structures of Pou5f1/Oct4 and cyclin B1 mRNAs persisted in 2-cell stage embryos. Pou5f1/Oct4 RNA granules exhibited a solid-like property in immature oocytes and became liquid-like droplets in 2-cell stage embryos. Double-staining of cyclin B1 mRNA with Emi2 or Pou5f1/Oct4 mRNA revealed that these mRNAs were distributed as different RNA granules without overlapping each other and that the size of cyclin B1 RNA granules tended to be larger than that of Emi2 RNA granules. The structures and distribution patterns of these mRNAs were further analyzed by N-SIM super-resolution microscopy. This analysis revealed that the large-sized RNA granules consist of many small-sized granules, suggesting the accumulation and regulation of dormant mRNAs as basal-sized RNA granules.
Conclusion
This method can easily visualize the structure and distribution of mRNAs accumulated in mammalian oocytes and embryos with high sensitivity and super-resolution. This method is useful for investigating the cellular and molecular mechanisms of translational control of mRNAs by which maturation and early developmental processes are promoted.
Association between class III obesity and overall survival in previously untreated younger patients with acute myeloid leukemia enrolled on SWOG S1203
Authors: Percival Mary-Elizabeth , Zhang Michelle , Othus Megan , McMillen Kerry , Erba Harry , Garcia-Manero Guillermo , Pagel John , Sorror Mohamed
Published: March 2024

There has been ongoing debate on the association between obesity and outcomes in acute myeloid leukemia (AML). Currently there are few studies that have stratified outcomes by class I obesity, class II obesity, and class III obesity; and a more nuanced understanding is becoming increasingly important with the rising prevalence of obesity. We examined the association between body mass index (BMI) and outcomes in previously untreated AML in younger patients (age ≤60) enrolled in SWOG S1203 (n=729). Class III obesity was associated with an increased rate of early death (p=0.004) and worse overall survival (OS) in multivariate analysis (hazard ratio (HR) 2.48, 95% confidence interval (CI) 1.62-3.80 versus normal weight). Class III obesity was also associated with worse OS after allogeneic hematopoietic cell transplant (HR 2.37, 95% CI 1.24-4.54 versus normal weight). These findings highlight the unique risk of class III obesity in AML, and the importance of further investigation to better characterize this patient population.
Photosynthetic Physiological Regulation Mechanism of VIRESCENT-ALBINO LEAF 1 in Rice (Oryza sativa L.)
Authors: Li Lingyi , Yang Shihui , Jiao Yingrui , Liu Yufei , Wang Bingbing , Zhang Hongmei , Hu Jian , Wang Guangyuan , Gul Shareef , Feng Ping , Zhang Ting , Ling Yinghua , He Guanghua , Yao Hesheng
Published: March 2024

Improving photosynthetic potential and light use efficiency is a crucial way to increase rice yield. The virescent-albino leaf 1 (val1) mutant, wild-type ‘Jinhui 10’ (WT), and VAL1 gene overexpression plants (VAL1-OE) were used to determine the physiological mechanisms of survival strategy in val1 mutant and improvement of photosynthetic potential in VAL1-OE through investigating leaf photosynthetic characteristics, photoprotection processes and yield. The results showed that, compared with WT, the expressions of key genes in photosynthetic pathway and chlorophyll contents in val1 mutant were both significantly lower at the early growth stage and higher at the late growth stage. Besides, the photosynthetic electron transport rate, the quantum yield of photosystem II and I, and carboxylation efficiency in val1 mutant were significantly lower than those in WT at the early growth stage, but significantly higher at the late growth stage. Furthermore, the non-photochemical quenching (NPQ) of val1 mutant was significantly higher than WT, thereby optimizing the heat dissipation pathway on the basis of reducing the chlorophyll contents and light absorption at the early growth stage. The NPQ and cyclic electron flow (CEF) were significantly higher in val1 mutant than WT at the late growth stage, resulting in the improvements of light use efficiency and photosynthetic acclimation under both low and high light conditions. Compared with WT, the expressions of key genes in photosynthetic pathway and chlorophyll contents were significantly higher in VAL1-OE. The photosynthetic electron transport rate, quantum yield of photosystem II and I, and the carboxylation efficiency in VAL1-OE were significantly higher than those in WT, improving light use efficiency and carboxylation efficiency of VAL1-OE. Overall, the val1 mutant survived by the optimal plant phenotype and leaf photoprotection pathway at the early growth stage, and improved photosynthetic potential and light use efficiency at the late growth stage. VAL1-OE improved light absorption by optimizing the dissipation pathway of excess light energy so as to increase light use efficiency and carboxylation efficiency. Cultivating phenotypic materials with high leaf area on the basis of high photosynthesis rate in VAL1-OE could be a breakthrough in high photosynthetic efficiency rice breeding.
Overexpression of COL4A1 promotes progression of colon cancer and is associated with poor prognosis
Authors: Li Qiusheng , Wang Changjing , Wang guiying
Published: March 2024

Background
Colon cancer is one of the common malignant tumor diseases of the digestive system, and its incidence and mortality rate are increasing year by year.Collagen type IV alpha 1 chain (COL4A1) is a hypoxia-associated gene (a collagen family protein) involved in the formation of the extracellular matrix.COL41 plays an important role in the progression of several cancers and is associated with poorer prognostic outcomes.However, whether it can mediate the progression of colon cancer is unclear.
Method
First, based on the TCGA-COAD dataset, we analyzed the mRNA expression levels of COL4A1 in colon cancer and evaluated the relationship between COL4A1 and clinicopathological features as well as prognosis.Then,we further analyzed the expression of COL4A1 in colon cancer tissues and colon tumor cells by qRT-PCR and HIC.Colon cancer cell lines SW480 and HCT116 were transfected with small interfering rna (siRNA) to construct low expression cell lines.Clone formation assay and transwell migration and invasion assays were used to detect the effects of knockdown of COL4A1 on proliferation, migration and invasion of colon cancer cells.
Result
Bioinformatics analysis showed that COL4A1 was significantly higher expressed in colon cancer tissues than in normal colon tissues. High expression of COL4A1 is associated with poor clinical stage and poor prognosis.We observed that COL4A1 was also highly expressed in colon cancer tissue and colon tumor cells compared with normal colon tissue and normal colon cells.Downregulation of COL4A1 significantly inhibited tumor cell proliferation, migration and invasion progression.
Conclusion
In summary, our study suggests that COL4A1 is a potential oncogene for colon cancer and can mediate colon cancer progression.
PPM1D/Wip1 is amplified, overexpressed, and mutated in human Non-Hodgkin Lymphomas
Authors: Pilevneli Hatice , Doger Firuzan , Karagenc Levent , Kozaci Leyla Didem , Eren Mehtap Kilic
Published: March 2024

Background Wip1, is a p53-dependent Ser/Thr phosphatase involved in the timely termination of DDR. ThePPM1Dgene encoding Wip1 is deregulated and thus gained an oncogene character in common human solid tumors and cell lines. This study assessed the oncogenic potential of thePPM1Dgene in human NHL, the most common hematological malignancy worldwide. Methods and Results FFPE human LH (n = 17) and NHL tumor lymph node samples (n = 65) and human NHL cell lines were used to assess the oncogenic potential of thePPM1Dgene in the present study. Copy number gain and mRNA expression analysis of thePPM1D/Wip1 gene were assessed by qRT-PCR analysis. Mutational analysis of Exon 6 of thePPM1Dgene was performed by PCR amplification and Sanger sequencing. Expressions of Wip1 and p53 proteins were assessed by immunohistochemistry and western blot analysis. Conclusions We found thatPPM1Dgained gene copy number in NHL tumors by 0.7-8 times compared to the control (p < 0.01). IncreasedPPM1D/Wip1 gene copy number was associated with higher mRNA and protein expression in human NHL samples (p < 0.01). Overexpression of Wip1 in NHL tumors and NHL cell lines was associated with amplification level and was unaffected by p53 status. Furthermore, a heterozygous type mutation was detected in exon 6 (c.1553C > A, p.518) of thePPM1Dgene particularly in DLBCL samples. Wip1 may have oncogenic potential, perhaps playing a role in the onset and progression of human NHL. The possible significance of Wip1 overexpression to chemotherapy response in NHL remains an intriguing question that requires more exploration.
Infection episodes and islet autoantibodies in children at increased risk for type 1 diabetes before and during the COVID-19 pandemic
Authors: Zeller Ivo , Weiss Andreas , Arnolds Stefanie , Schütte-Borkovec Katharina , Arabi Sari , Berge Thekla , Casteels Kristina , Hommel Angela , Kordonouri Olga , Larsson Helena Elding , Lundgren Markus , Rochtus Anne , Snape Matthew D , Szypowka Agnieszka , Vatish Manu , Winkler Christiane , Bonifacio Ezio , Ziegler Anette-Gabriele
Published: March 2024

Purpose. To determine the impact of the COVID-19 pandemic on the incidence rates of infection and islet autoimmunity in children at risk for type 1 diabetes. Methods. 1050 children aged 4 to 7 months with an elevated genetic risk for type 1 diabetes were recruited from Germany, Poland, Sweden, Belgium and the UK. Reported infection episodes and islet autoantibody development were monitored until age 40 months from February 2018 to February 2023. Results. The overall infection rate was 311 (95% Confidence Interval [CI], 304–318) per 100 person years. Infection rates differed by age, country, family history of type 1 diabetes, and period relative to the pandemic. Total infection rates were 321 per 100 person-years (95% CI, 304–338) in the pre-pandemic period (until February 2020), 160 (95% CI, 148–173) per 100 person-years in the first pandemic year (March 2020 - February 2021; P < 0.001) and 337 (95% CI, 315–363) per 100 person-years in subsequent years. Similar trends were observed for respiratory and gastrointestinal infections. Islet autoantibody incidence rates were 1.6 (95% CI, 1.0-2.4) per 100 person-years in the pre-pandemic period, 1.2 (95% CI, 0.8–1.9) per 100 person-years in the first pandemic year (P = 0.46), and 3.4 (95% CI, 2.3–4.8) per 100 person-years in subsequent years (P = 0.005 vs. pre-pandemic year; P < 0.001 vs. first pandemic year). Conclusions. The COVID-19 pandemic significantly altered infection patterns. Islet autoantibody incidence rates increased two-fold when infection rates returned to pre-pandemic levels.
Histo-morphological changes induced by nano nickel particles in rat testis
Authors: Singh Meenu , Verma Yeshvandra , Rana S V S
Published: March 2024

Exposure to nickel nanoparticles is known to cause adverse health effects in man and animal models. Present investigations were undertaken to determine the histo-morphological changes induced by nickel nanoparticles in testis of Wistar rats with special reference to duration of exposure. Suitable numbers of rats were fed with NiONPs and NiOMPs (5mg/kg b.w.each) for 15 and 30 days. Testes were removed and processed for histopathological, histochemical and SEM observations. Bioconcentration of nickel in testis and serum level of testosterone were also estimated. The results showed that NiONPs and NiOMPs could induce specific time dependent lesions in the testis of rat. Degeneration of germinal epithelium, spermatocytes, hypertrophy of seminiferous tubules and necrosis were observed. Localization of alkaline phosphatase was also altered. SEM results also indicated specific morphological changes in cellular components of tubules. In conclusion, present study suggests that testis is a target organ of NiONPs toxicity where its exposure time dependent effects are expressed. The results will be helpful in understanding the reproductive toxicity of new materials.
Dialyl-sulfide with chalcone prevent breast cancer prohibiting SULT1E1 malregulations and oxidant-stress induced HIF1a-MMPs induction
Authors: Nazmeen Aarifa , Maiti Sayantani , Maiti Smarajit
Published: March 2024

Background: In some breast cancers, decreased estrogen-sulfotransferase (SULT1E1) and its inactivation caused by oxidative-stress lead to elevated E2 levels as well as hypoxia-inducible tissue-damaging factors.
Methods: Here, matrix-metalloproteases (MMP2/9) activity and SULT1E1-HIF1α protein/gene expression (Western-blot/RTPCR) were assessed in human breast-cancers versus their adjacent-tissues. Oxidant-stress neutralizer, chalcone (α,β unsaturated ketone) and SULT1E1-inducer pure vdialyl-sulfide (source garlic; Allium sativum) were tested to prevent cancer causing factors in rat, in-vitro and in-vivo model. The antioxidant-enzymres SOD1, catalase, GPx and LDH, and matrix-degenerating MMP2/9 activities were assessed (gel-zymogram). Histoarchitecture (HE-staining) and tissue SULT1E1-localization (immuno-histochemistry) were screened. Extensive statistical-analysis were performed.
Results: Human cancer-tissue expresses higher SULT1E1, paralleling HIF1α protein/mRNA owing to lower LDH activity. In addition, increase of MMP2/9 activities commenced tissue damage. However, chalcone and DAS significantly induced SULT1E1 gene/protein, and suppressed HIF1α expression, and MMP2/9 activities in rat tissues. Correlation of individual parameter statistics and group statistics of t-test suggest significant correlation of oxidative-stress (MDA) with SULT1E1 (p=0.006), HIF1α (p=0.006) protein-expression. The non-protein-thiols showed a negative correlation (p=0.001) with HIF1α. These two proteins and SULT1E1 mRNA expressions in human breast tumor were significantly higher (p<0.05) compared to the adjacent tissues. Pearson correlation data suggest, SULT1E1 is correlated with non-protein-thiols in different exposure groups.
Conclusions: Breast cancers associate with SULT1E1, HIF1α and MMPs deregulations. We are reporting for the first time that higher SULT1E1-protein in advanced cancer, remain inactive in oxidative environment and may be re-activated in chalcone induced reducing-state. Moreover, DAS induced SULT1E1 mRNA expression augments its protein synthesis. Synergistic drug-effects commenced HIF1α and MMPs suppression. Further studies are necessary.
Ethnic disparities and lifestyle determinants in the prevalence of cardiovascular disease among Han majority and Ha Ni ethnic minority older adults in rural Southwest China
Authors: HUANG You , LI Qin , ZUO Mei , LIU Lan , LI Guo-hui , CAI Le
Published: March 2024

Objectives
Cardiovascular disease (CVD) is the leading cause of death in China. To provide evidence for preventing and controlling the development of CVD among older adults in ethnic minority communities by understanding the ethnic disparities and lifestyle determinants of CVD. This study aimed to compare ethnic disparities and lifestyle determinants in the prevalence of CVD (hypertension, CHD, and stroke) among older adults between Han majority and Ha Ni ethnic minority in rural southwest China.
Methods
A cross-sectional questionnaire and physical examination were conducted among Han majority and Ha Ni ethnic minority groups aged ≥ 60 years in rural Southwest China. Height, weight, waist circumference and blood pressure values of each participant were recorded. The relationship between ethnic and lifestyle factors and CVD was analyzed using multivariate logistic regression.
Results
A total of 1413 Han majority and 1402 Ha Ni ethnic minority elderly individuals participated in this study. Han majority older adults had a higher prevalence of CHD and stroke than in Ha Ni ethnic minority counterparts (P < 0.01). Compared with the Han majority elderly, Ha Ni ethnic minority older adults had a higher risk of hypertension (OR = 1.168, 95%CI: 1.070–1.274), and a lower risk of CHD (OR = 0.818, 95%CI: 0.680–0.985) and stroke (OR = 0.736, 95%CI: 0.605–0.895). Participants with obesity were more likely to have hypertension (OR = 2.092, 95%CI: 1.344–3.255) and CHD (OR = 2.259, 95%CI: 1.341–3.808). Additionally, those who with central obesity and physically inactivity were more likely to have hypertension (OR = 2.349, 95%CI: 1.930–2.858 and OR = 1.303, 95%CI: 1.105–1.537) and stroke (OR = 2.205, 95%CI: 1.384–2.962 and OR = 2.024, 95%CI: 1.405–2.916). Current drinking increased the risk of hypertension (OR = 1.311, 95%CI: 1.077–1.596), but decreased the risk of stroke (OR = 0.428, 95%CI: 0.243–0.754).
Conclusion
CHD and stroke are more prevalent among the Han majority older adults in rural Southwest China, and there is a significant influence of lifestyle factors on CVD.
Multimodal Representation and Cross Modal Enhancement for Short Video Recommendation
Authors: Jae-won Song , Yoo-jin Kang , Min-seok Jang
Published: March 2024

The surge in short video content production on various platforms has marked the emergence of short videos as a new and popular form of media. However, the sheer abundance and complexity of short video data present challenges for effective video recommendation. Short videos encapsulate rich multimodal information across both temporal and spatial dimensions, allowing users to engage with videos in various ways—whether focusing on the content of a particular shot, delving into the storyline, or enjoying the accompanying music. Conventional video recommendation systems typically focus on a singular type of recommended content, providing recommendations for entire videos, which may not fully satisfy the nuanced preferences of users. In multimodal data, each modality contributes specific information to the others, establishing correlations between them. In the context of video data, which combines image, speech, and text data, understanding the relationships among these three media types is crucial for effective multimodal content-based video recommendation. In this paper, we leverage the consistency of multimodal features for understanding multimedia content, aiming to derive a robust representation from the inherent characteristics of short videos. Unlike previous studies that primarily concentrate on a single modality in short video recommendation, our approach capitalizes on the multimodality of short video content and adopts a multimodal recommendation strategy. By extracting and fusing information from multiple modalities, we achieve a more comprehensive short video content analysis, paving the way for our recommendation method.
Deciphering omics atlases to aid stony corals in response to global change
Authors: He Chunpeng , Han Tingyu , Huang Wanlong , Wang Bing , Liao Xin , Chen J.-Y. , Lu Zuhong
Published: March 2024

Coral reefs are rapidly declining due to global climate change1. Alongside environmental protection, gene engineering technologies are essential in protecting reef-building (stony) corals2-7. Precise multi-omics backgrounds are crucial for gene technique application8-13 and understanding stony coral biology2-5. However, high heterozygosity4,14 and exogenous sequence contamination15-17 impede high-quality stony coral genome assembly. To address this, we developed a workflow for stony coral genome assembly, achieving four high-quality chromosome-level genomes (Acropora muricata, Montipora foliosa, M. capricornis, and Pocillopora verrucosa). A global synteny analysis of chromosomes and homeobox genes highlighted the highly conserved features of Scleractinia stony coral genomes, even after an evolutionary divergence 250 million years ago (mya). Single-cell RNA sequencing (scRNA-seq), combined with a pan-genomic analysis, aided our understanding of symbiosis and calcification, both issues of conservation concern. A dynamics simulation of the mechanism of systemic RNA interference defective protein 1 transmembrane family member 1 (SIDT1) tetramer offered a potential approach to observe gene impacts on stony corals. This work enhances understanding of the evolutionary, molecular, and cellular aspects of stony corals and provides a detailed dataset for applying gene engineering technologies in response to global climate challenges.
Integrating Protein Structure Prediction and Bayesian Optimization for Peptide Design
Authors: Xu Dong
Published: March 2024

Peptide design, with the goal of identifying peptides possessing unique biological properties, stands as a crucial challenge in peptide-based drug discovery. While traditional and computational methods have made significant strides, they often encounter hurdles due to the complexities and costs of laboratory experiments. Recent advancements in deep learning and Bayesian Optimization have paved the way for innovative research in this domain. In this context, our study presents a novel approach that effectively combines protein structure prediction with Bayesian Optimization for peptide design. By applying carefully designed objective functions, we guide and enhance the optimization trajectory for new peptide sequences. Benchmarked against multiple native structures, our methodology is tailored to generate new peptides to their optimal potential biological properties.
Gene expression biomarkers differentiate overall survival of colorectal cancer upon targeted therapies
Authors: Yazdani Akram , Yazdani Azam , Mendez-Giraldez Raul , Pillonetto Gianluigi , Samiei Esmat , Hadi Reza , Lenz Heinz-Josef , Venook Alan , Samiei Ahmad , Nixon Andrew ,   Joseph Lucci 3rd, Kopetz Scott , Bertagnolli Monica , Perou Charles , Innocenti Federico
Published: March 2024

While monoclonal antibody-based targeted therapies have substantially improved progression-free survival in cancer patients, the variability in individual responses poses a significant challenge in patient care. Therefore, identifying cancer subtypes and their associated biomarkers is required for assigning effective treatment. In this study, we integrated genotype and pre-treatment tissue RNA-seq data and identified biomarkers causally associated with the overall survival (OS) of colorectal cancer (CRC) patients treated with either cetuximab or bevacizumab. We performed enrichment analysis for specific consensus molecular subtypes (CMS) of colorectal cancer and evaluated differential expression of identified genes using paired tumor and normal tissue from an external cohort. In addition, we replicated the causal effect of these genes on OS using validation cohort and assessed their association with the Cancer Genome Atlas Program data as an external cohort. One of the replicated findings was WDR62, whose overexpression shortened OS of patients treated with cetuximab. Enrichment of its over expression in CMS1 and low expression in CMS4 suggests that patients with CMS4 subtype may drive greater benefit from cetuximab. In summary, this study highlights the importance of integrating different omics data for identifying promising biomarkers specific to a treatment or a cancer subtype.
A case of metacarpal coloboma caused by Tumor-induced Osteomalacia treated with bone cement prosthesis and literature review
Authors: Huang Chuanhong , Dong Panfeng , Chen Yueping , Chen Shangtong
Published: March 2024

Tumor-induced osteomalacia (TIO) is a rare disease known as hypophosphoric osteomalacia (HO). Phosphaturic mesenchymal tumor (PMT) is the pathological basis of most TIO patients and is caused by abnormal secretion of fibroblast growth factor 23 (Fibroblast Growth Factor 23, PMT). FGF-23 causes abnormal renal phosphate consumption and hypophosphatemia and is often subject to repeated examination and treatment before diagnosis, and the process of definitive diagnosis usually lasts several years. Most of these patients can be cured by surgical resection of the tumor, but the tumor causing this disease is often small in size, hidden in location, and difficult to detect. Multiple examination methods are needed to determine the location of the tumor, and cases of complete bone loss caused by direct tumor erosion have not been reported in the literature. We report a case in which the third metacarpal bone was lost due to direct tumor erosion, which was treated with prostheses made of bone cement. We also reviewed the relevant literature to explore the diagnosis of tumor-related osteomalacia and the treatment strategy used for this extremely rare case.
A case report of Inguinal Endometriosis-A rare entity of a common condition
Authors: Rodrigo Nilan
Published: March 2024

Background: This case report discusses the presentation, diagnostic challenges, and successful surgical management of inguinal endometriosis(IEM).
Case presentation: A 46-year-old Sinhalese woman experienced a painful lump in the right groin area for 5 years, with exacerbation during menstruation, coughing, and sneezing. Initial treatment, with depot methylprednisolone acetate injection, was ineffective. Two years later, at a different hospital, an endometriotic mass was identified in the right inguinal region, excision was not performed because of the propensity for vascular injury instead three doses of depot medroxyprogesterone acetate(DMPA) significantly alleviated the pain. When she presented to our hospital, a provisional diagnosis of right inguinal endometriosis was made after an ultrasound examination. A multidisciplinary approach involving a surgeon was employed for excision surgery, with meticulous attention given to avoiding femoral vein injury. The 45x25x25 mm mass, located in the inguinal ligament, was successfully removed.
Conclusion: This case underscores the importance of collaboration between specialties for accurate diagnosis and effective surgical management of inguinal endometriosis. Preoperative imaging is useful, but the final diagnosis can be confirmed only after surgical excision and histopathology
Advanced Key Expansion Algorithm Using a High-Performance Four-Dimensional Chaotic Map and a Strong S-Box for Enhanced Sensitivity and Independence
Authors: Li Yuxuan
Published: March 2024

The round key is pivotal to the integrity of block encryption algorithms, derived from the initial key via the key expansion process to enhance security measures. This study introduces an innovative key expansion algorithm, underpinned by a high-performance four-dimensional chaotic map and a durable S-box, distinguishing itself through key sensitivity and independence, thereby enhancing defense against diverse cryptographic attacks. We debut a four-dimensional chaotic map, lauded for its exceptional dynamic qualities as evidenced through rigorous behavior analysis. Furthermore, we develop an S-box generation method utilizing operations in the finite field GF(28), producing an S-box characterized by its high nonlinearity and fortified security. This S-box is meticulously designed to avoid common vulnerabilities such as fixed points, reverse fixed points, and brief periods, rendering it ideal for key expansion purposes. Leveraging the strengths of the chaotic map and S-box, we detail our key expansion algorithm and validate its security efficacy through comprehensive analysis, highlighting its potential as a robust tool in cryptographic security.
Evaluation of Turbo expander technologies for FLNG
Authors: Chan We Lin
Published: March 2024

The global increase in carbon emission is one factor in using clean fuels to minimise air pollution by avoiding fossil fuel usage in the marine sector. The current effort of changing the energy source to LNG fossil gas fuel was assumed to be the cleanest fuel due to lower carbon emission to ease the rapid growth of carbon emission. Recent development in the LNG market drives the shipyard industry to build the LNG offshore platform FLNG, which is like the LNG plant with no land base but offshore. The LNG marine industry forecasts that increasing demand for FLNG vessels will accelerate the de-velopment of gas resources, research work on the system process analysis and optimisation of the Liquefaction system. The rapid growth in equipment and processes of FLNG development is the response to weight and space limits challenges. This paper describes the optimisation process of LNG turboexpander technologies’ benefits based on the different pro-cesses. Since the Single Nitrogen Expander that less efficiency and irreversible losses, another consideration of the dual expander process models and comparison from the simple model to the complex expander process. This article will focus on the LNG liquefaction research process results and analyses the design and optimisation based on power consumption, LNG production and future research directions of FLNG. This research is to aid in a small-scale liquefaction process with a refrigerant cycle proposed in this study to meet these FLNG challenges. The research methodology is to study all models of the expander liquefaction process and analyse the differential pressure of natural gas entry to vary the temperature, heat flow, exergy, and enthalpy. The Aspen Plus and Hysys simulator used a state-of-the-art run simulation for processes for all models.
Esports Physical Exercise/Performance Matrix 1.0 Country Factsheets: A Protocol for National, Regional and Global Annual Assessment
Authors: Long Bo , AGUDAMU AGUDAMU , Matic Radenko , Popovic Stevo , Bu Te
Published: March 2024

This protocol was developed to allow evaluators to collect up-to-date data and produce a comprehensive annual assessment through several specific indicators and ensure the outcomes that include the most relevant evidence about physical activity/exercise for esports players from each country and recognition of particular barriers for physical activity/exercise. For this reason, this manuscript aims to create a methodology that will provide a better basis for establishing a standardized monitoring system on physical exercise and performance in esports players at national and regional levels as well as globally. This study protocol proposed 20 sociodemographic indicators that are available online and it will be compiled to identify the characteristics of the participating countries and describe country's demographic profile. On the other hand, this protocol proposed nine content indicators that were singled out for the assessment of physical exercise and performance in esports players. To evaluate each of the content indicators, a separate analysis has to be conducted, and a ten-point grading scale will be employed. This study protocol will initiate the national evaluators (researchers) to meet annually to produce national reports (the Country Factsheets) that will ensure effective and dynamic linkages between research and practice.
The role of environmental performance in mediating the relationship between green accounting and corporate social responsibility
Authors: Ratmono Dwi , Mail Rasid , Cahyonowati Nur , N. A. Janie Dyah
Published: March 2024

The problems of pollution, global warming, and environmental damage are currently relevant and vital challenges for corporations, governments, and society. The implementation of green accounting is one of the responses of corporations to overcome sustainability issues. This study aims to examine the impact of green accounting on the level of environmental performance and the impact of environmental performance on corporate social responsibility (CSR) disclosure. This study also tests the role of environmental performance as a mediating variable in the relationship between green accounting and CSR disclosure. The sample consists of 95 listed Indonesian firms during the period 2017–2021. The results show that the adoption of green accounting positively affects environmental performance (coefficient is 0.291 and p-value < 0.01). Meanwhile, environmental performance positively affects CSR disclosure with a coefficient of 0.296 and a p-value < 0.01. The empirical evidence also shows that environmental performance has a critical role as a mediating variable in the effect of green accounting on CSR disclosure.
A coroa e a espada no espetáculo das nações
Authors: Ferreira Túlio Sérgio Henriques , Souza Lucas
Published: March 2024

Analisam-se as autoimagens construídas pelo governo brasileiro para duas Exposições Universais oitocentistas (Paris 1889 e Saint Louis 1904). Busca-se entender o conteúdo e interesses dessas autoimagens propagadas nesses eventos, a primeira ocorrida no Império e a segunda no período republicano brasileiro. O trabalho concorda que essas participações eram uma proto-diplomacia pública utilizada para melhorar a imagem internacional do Brasil. Pela análise qualitativa bibliográfica e documental primária, foram estabelecidos quatro âmbitos: político, modernidade, econômico e racial. Dos quatro, apenas o político apresentou alterações. A despeito das alterações na política externa, nos demais eixos, foram observadas a manutenção das imagens.
Segurança ou Direitos Humanos? Uma análise do processo de legalização da Cannabis no Uruguai
Authors: Facchini da Silva Allana , Moreira de Souza Rodrigues Thiago
Published: March 2024

Considerando o processo de legalização da Cannabis no Uruguai, trabalhamos a hipótese de que a estratégia operada pelo país se fundamentou numa lógica securitária, em contraste com os discursos pró-canábicos globais. Utilizando-nos de técnicas de análises qualitativas e do marco teórico-metodológico do Drug Policy Framework, concluímos que o apelo à lógica securitária foi a via para alterar o status jurídico da Cannabis, pois, na dimensão dos valores morais, a defesa dos direitos humanos não mobilizaria transformações legais. A principal contradição deste processo é que os argumentos securitários, histórica e internacionalmente, fundamentam a proibição das drogas e suas políticas repressivas.
A NEW STUDY ON RHYTHMIC STYLE AND ON THE COOPERATION WITH MUSIC ABOUT NEW YUEFU BY BO JUYI — TAKING NEW YUEFU PULLING UP THE SILVER BOTTLE FROM THE BOTTOM OF THE WELL AS AN EXAMPLE
Authors:   Tianjin University, Niu Qian
Published: March 2024

This paper takes the rhyme analysis of the famous poem Pulling up the Silver Bottle from the Bottom of the Well in Bo Juyis New Yuefu as an example, discussing three important issues in the study of Bo Juyi’s New Yuefu poetic form: 1) put forward five differences between Bo Juyi’s New Yuefu and traditional Yuefu; 2) put forward “the view that rhyme and passage are closely related” and discusse the characteristics of rhyme segment, which reflects the plot structure of the poem and is highly consistent with the music segment. As a poem of “preparing for music”, the New Yuefu has many similarities with the traditional Yuefu in its poetic form; 3) put forward “the theory of the relationship between Yuefu melody and emotion”. This theory is only applicable to literature with musical accompaniment, such as New Yuefu; 4) put forward that the New Yuefu has “colorful movement theory”.
BAI JUYI AND ORIGINS OF THE NEW YUEFU
Authors:   St. Petersburg State University, Storozhuk Alexander
Published: March 2024

The first poetic cycle of 50 New Yuefu was written by Bo Juyi (白居易, 772–846) in 809 after the works of by his friend Li Shen (李紳, 772–846). Bo Juyi wrote it simultaneously with another great Tang poet Yuan Zhen (元稹, 779–831), and the new literary style has been known for centuries as Yuan-Bo (元白). Both of the poets shared the same attitude towards the role of letters in the society and aspired to implement their credo at the official posts they held. The origin of New Yuefu philosophy dates back at least to 806, when he together with Yuan Zhen created the illustrious political composition known as Celin (策林), where the bulk of their sociopolitical concepts were pronounced and stated. Most of these notions, inspired by Fugu movement, seem quite predictable and naive: the belief in an omni harmonizing role of ancient ritual, claim of necessity to promote worthy and knowledgeable, appeal to stop war and cut taxes. With all that this was a declaration of primary of benevolence over quasi orderliness, and this idea fully revealed later in New Yuefu poetry. Surely enough, New Yuefu have not been limited to the 50 poems, inspired by Li Shen. The new poetic experience gave birth to a whole literary trend, covering the most burning, up-to-date issues of contemporaneousness as well as the nearest past, picturing typical characters of different strata, pointing out social diseases and perils. The absolute trust in uppermost ritual role of a text has been embodied in such texts as, for example, Song of Eternal Grief (《長恨歌》), where the infamous story of Emperor Xuan-zong (玄宗, 685–762) and his favorite concubine Yang Gui-fei (楊貴妃, 719–756) found a new interpretation, that later would have become mainstream. Thus, the main conclusions are: 1) New Yuefu had a philosophic basement, carried out long before the first poem of the new style appeared; 2) its main goal was to revive the actual social role of poetry; 3) it had a great impact on the later Chinese poetry and social thought.
THANSLATIONS OF BO JUYI’S POEMS IN RUSSIA UNDER THE VIEW OF “LIBERTY RATE”
Authors:   Shandong University, Zhang Shujuan , Zhao Chengbiao ,   Tianjin University of Commerce
Published: March 2024

This article systematically examines the Russian translation of Bо Juyi’s poems by Russian sinologists in different periods and quantifies the evaluation of poetry translation by using the “measure of liberty” and “measure of accuracy” of Russian literary theorist M. L. Gasparov, through which we analyze the degree of relativity between different translations and the original works. The Soviet period was the period when Bо Juyi’s poems were most translated, and there were translations by Ju. K. Shucki, B. A. Vasiliev, L. Z. Edlin, and V. F. Pereleshin. In the new era, Russian Sinology inherited the tradition initiated by V. M. Alekseev, S. A. Toroptsev and N. A. Orlova continued to translate Bо Juyi’s poetry with frequent excellent works. The article points out that Russian sinologists attach importance to the reproduction of these factors of prosody, such as rhymes, rhythms, and verse in translating Bо Juyi’s poems.
ON THE HEROIC SPIRIT OF BAI JUYI’S POETRY
Authors:   Capital University of Economics and Business, Zhao Jianmei
Published: March 2024

Bai Juyi’s poetry creation generally pursues the easy style, but there is also a strong side in the easy style. The mutual integration and dialectical unity of easy style and strong strength constitute the diverse features of his poetry. His poems often show pride when writing about the theme of caring for the country and people’s livelihood, strong and broad when writing about the natural landscape, and momentum in poems on things. This heroic spirit is not only reflected in Bai Juyi’s allegorical poems, but also in his leisure poems and sentimental poems. These poems are full of emotion. Poet is good at selecting magnificent and vigorous images, words conveying power and breadth, and often use vigorous images as metaphors. The heroic spirit in Bai Juyi’s poetry is not only influenced by Du Fu, a poet of the prosperous Tang Dynasty, and Liu Yuxi, a poet of the same era, but also closely related to the overall atmosphere of advocating heroism in the poetry circle of the middle Tang Dynasty; The Confucian spirit hidden in his heart and the heroic spirit in his temperament are the internal root of the heroic spirit in Bai poetry.
SPECIAL FEATURES AND SIGNIFICANCE OF THE EARLY RECENSION OF THE BAOJUAN OF XIANGSHAN IN THE HANOI REPRINT EDITION (1772)
Authors:   Fudan University, Berezkin Rostislav ,   Institute of Oriental Studies of the Russian Academy of Sciences
Published: March 2024

The Hanoi reprint edition of the Baojuan of Xiangshan (1772) is a rare text of Chinese popular literature preserved out of China; it reproduces the edition from Nanjing. It retells the legend of Princess Miaoshan, considered to be an earthly reincarnation of Bodhisattva Guanyin, which is one of the most popular Buddhist narrative subjects in China. This recension till recently remained almost unknown in the world sinology. Special features of form and contents of this text prove its comparatively early origins (15th — early 16th century). The unusual structure of the Baojuan of Xiangshan, which includes quotations from the chapter “Gates of Universal Salvation” in the famous Lotus Sutra, establishes its connection with this sacred book of Buddhism and the tradition of Buddhist preaching with the use of sutra subjects that developed in China in the earlier period (7th–13th centuries). This feature of text is very important for the study of origins of baojuan genre and its development in the early period (14th–16th centuries). The Baojuan of Xiangshan represents an early version of the Miaoshan legend, in which Buddhist ideas were connected with Chinese concepts and realities. This subject that formed in China ca. beginning of the 12th century represents adaptation of Buddhist teaching, primarily aimed at lay folk believers. It is symptomatic that it enjoyed popularity in the form of baojuan, designed to be recited for the broad audiences.
GUO MORUO’S MY CHILDHOOD AND HU SHI’S SELF-NARRATION AT FORTY: COMMON AND SPECIAL FEATURES IN REPRESENTATION OF NEW MAN OF THE NEW ERA
Authors:   Far Eastern Federal University, Kurako Julia
Published: March 2024

The genre of literary autobiography started its formation in China during the New Culture Movement and entered a phase of rapid development by the end of the 1920s. A new understanding of autobiography as a generalized and objectified experience of the writer generated the diversified and syncretic form based on the combination of national tradition and foreign experience. The most representative works of that period are Guo Moruo’s My Childhood (1928) and Hu Shi’s Self-narration at Forty (1933). Based on the main characteristics of the genre of literary autobiography in world literature, the present article attempts to compare these two works in order to identify similarities and differences in authors’ approaches to the representation of personality, as well as to reveal typological features of the Chinese literary autobiography genre of the first half of the 20th century.
MYSTICISM AND FOLKLORE IN LIU ZHENYUN’S NOVEL LAUGHTER AND TEARS
Authors:   St. Petersburg State University, Rodionova Oxana
Published: March 2024

The article examines the elements of mysticism and folklore in the novel Laughter and Tears (2021) by Chinese writer Liu Zhenyun (born 1958). In modern Chinese literature, there are many works in which everyday reality is described with the help of mystical and folklore elements. Examples of this kind of narration are the prose of Mo Yan, Jia Pingwa, Chen Zhongshi, Han Shaogong. In Liu Zhenyun’s novel Laughter and Tears mysticism and folklore are not so much auxiliary means as a kind of framework and play a plot-forming role. The legend of Hua Erniang, the legend of the White Snake, the Yanjin “tales”, the reincarnations of the souls of the dead, the relocation of ghosts into the bodies of people, traditional divination practices — all these are the tools by which the fates of people, ghosts and immortals intersect and merge in the novel. This kind of narration perfectly reflects the current state of folk culture and customs in the Chinese hinterland, which in the novel is represented by Yanjin. Liu Zhenyun skilfully uses folk tales and mystical elements to overcome the barriers between reality, imagination and fantasy, blurring the line between life and death. Having studied the motives of the author’s use of elements of mysticism and folklore in the novel Laughter and Tears, it can be argued that they are the driving force of the narrative and are pivotal for the plot of the novel, developing and deepening it’s theme about the fate of people and interpersonal relationships.