bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of an Electronic Portal Imaging Device Dosimetry Method
Authors: Zhang Jun , Fan Ziting , Zhang Xile , Yang Ruijie , Wen Junhai
Published: September 2021

Support arm backscatter and off-axis effects of an electronic portal imaging device (EPID) are challenging for radiotherapy quality assurance. Aiming at the issue, we proposed a simple yet effective method with correction matrices to rectify backscatter and off-axis responses for EPID images. First, we measured the square fields with ionization chamber array (ICA) and EPID simultaneously. Second, we calculated the dose-to-pixel value ratio and used it as the correction matrix of the corresponding field. Third, the correction value of the large field was replaced with that of the same point in the small field to generate a correction matrix suitable for different EPID images. Finally, we rectified the EPID image with the correction matrix, and then the processed EPID images were converted into the absolute dose. The calculated dose was compared with the measured dose via ICA. The gamma pass rates of 3%/3 mm and 2%/2 mm (5% threshold) were 99.6% ± 0.94% and 95.48% ± 1.03%, and the average gamma values were 0.28 ± 0.04 and 0.42 ± 0.05, respectively. Experimental results verified our method accurately corrected EPID images and converted pixel values into absolute dose values such that EPID was an efficient radiotherapy dosimetry tool.
Biological Significance of the Protein Changes Occurring in the Cerebrospinal Fluid of Alzheimer’s Disease Patients: Getting Clues from Proteomic Studies
Authors: Pedrero-Prieto Cristina M. , Frontiñán-Rubio Javier , Alcaín Francisco J. , Durán-Prado Mario , Peinado Juan R. , Rabanal-Ruiz Yoana
Published: September 2021

The fact that cerebrospinal fluid (CSF) deeply irrigates the brain together with the relative simplicity of sample extraction from patients make this biological fluid the best target for biomarker discovery in neurodegenerative diseases. During the last decade, biomarker discovery has been especially fruitful for the identification new proteins that appear in the CSF of Alzheimer’s disease (AD) patients together with amyloid-β (Aβ42), total tau (T-tau), and phosphorylated tau (P-tau). Thus, several proteins have been already stablished as important biomarkers, due to an increase (i.e., CHI3L1) or a decrease (i.e., VGF) in AD patients’ CSF. Notwithstanding this, only a deep analysis of a database generated with all the changes observed in CSF across multiple proteomic studies, and especially those using state-of-the-art methodologies, may expose those components or metabolic pathways disrupted at different levels in AD. Deep comparative analysis of all the up- and down-regulated proteins across these studies revealed that 66% of the most consistent protein changes in CSF correspond to intracellular proteins. Interestingly, processes such as those associated to glucose metabolism or RXR signaling appeared inversely represented in CSF from AD patients in a significant manner. Herein, we discuss whether certain cellular processes constitute accurate indicators of AD progression by examining CSF. Furthermore, we uncover new CSF AD markers, such as ITAM, PTPRZ or CXL16, identified by this study.
High-Rate Continuous-Variable Quantum Key Distribution with Orbital Angular Momentum Multiplexing
Authors: Ruan Xinchao , Shi Wenhao , Chen Guojun , Zhao Wei , Zhang Hang , Guo Ying
Published: September 2021

The secret key rate is one of the main obstacles to the practical application of continuous-variable quantum key distribution (CVQKD). In this paper, we propose a multiplexing scheme to increase the secret key rate of the CVQKD system with orbital angular momentum (OAM). The propagation characteristics of a typical vortex beam, involving the Laguerre–Gaussian (LG) beam, are analyzed in an atmospheric channel for the Kolmogorov turbulence model. Discrete modulation is utilized to extend the maximal transmission distance. We show the effect of the transmittance of the beam over the turbulent channel on the secret key rate and the transmission distance. Numerical simulations indicate that the OAM multiplexing scheme can improve the performance of the CVQKD system and hence has potential use for practical high-rate quantum communications.
A General Metric for the Similarity of Both Stochastic and Deterministic System Dynamics
Authors: Shea-Blymyer Colin , Roy Subhradeep , Jantzen Benjamin
Published: September 2021

Many problems in the study of dynamical systems—including identification of effective order, detection of nonlinearity or chaos, and change detection—can be reframed in terms of assessing the similarity between dynamical systems or between a given dynamical system and a reference. We introduce a general metric of dynamical similarity that is well posed for both stochastic and deterministic systems and is informative of the aforementioned dynamical features even when only partial information about the system is available. We describe methods for estimating this metric in a range of scenarios that differ in respect to contol over the systems under study, the deterministic or stochastic nature of the underlying dynamics, and whether or not a fully informative set of variables is available. Through numerical simulation, we demonstrate the sensitivity of the proposed metric to a range of dynamical properties, its utility in mapping the dynamical properties of parameter space for a given model, and its power for detecting structural changes through time series data.
Entropy as a Topological Operad Derivation
Authors: Bradley Tai-Danae
Published: September 2021

We share a small connection between information theory, algebra, and topology—namely, a correspondence between Shannon entropy and derivations of the operad of topological simplices. We begin with a brief review of operads and their representations with topological simplices and the real line as the main example. We then give a general definition for a derivation of an operad in any category with values in an abelian bimodule over the operad. The main result is that Shannon entropy defines a derivation of the operad of topological simplices, and that for every derivation of this operad there exists a point at which it is given by a constant multiple of Shannon entropy. We show this is compatible with, and relies heavily on, a well-known characterization of entropy given by Faddeev in 1956 and a recent variation given by Leinster.
Editorial Introduction to the Special Issue “Teachers Matter—Improving Recruitment, Retention and Development of Teachers”
Authors: See Beng Huat , Morris Rebecca
Published: September 2021

This Special Issue of Education Sciences on the theme of Education Matters was commissioned in recognition of the important role that teachers play in the development of students’ learning and wider outcomes [...]
Modeling the Level of User Frustration for the Impaired Telemeeting Service Using User Frustration Susceptibility Index (UFSI)
Authors: Mrvelj Štefica , Matulin Marko
Published: September 2021

Modern users are accustomed to always-accessible networks ready to serve all of their communication, entertainment, information, and other needs, at the touch of their devices. Spoiled with choices provided on the competitive markets, the risk of customer churn makes network and service providers sensitive to user Quality of Experience (QoE). Services that enable people to work and industries to function in these pandemic times, such as the telemeeting service, are becoming ever more critical, not just for the end-users but also for the providers. Nevertheless, the heterogeneity of end-users network environments and the uniqueness of the service (bidirectional video and audio transmissions and interactivity between the meeting peers) imposes specific QoE requirements. Hence, this paper focuses on understanding how different service quality degradations affect user perception and frustration with such impaired service. The impact of eight quality degradations was analyzed. Based on the conducted user study, we used the multiple regression analysis and developed three models capable of predicting user Level of Frustration (LoF) for the specific degradations that we have analyzed. The models work with the User Frustration Susceptibility Index (UFSI), which categorizes users into groups based on their tendency to become frustrated with the impaired service.
Factors Contributing to Korean Older Adults’ Acceptance of Assistive Social Robots
Authors: Wang Lin , Chen Jia , Ju Da-Young
Published: September 2021

This study investigated the factors contributing to older adults’ acceptance of assistive social robots. A survey was conducted to find factors explaining and predicting older adults’ acceptance behavior of assistive social robots. Three factors of older adults’ needs for assistive social robots were found (advanced needs, social needs, and physiological needs) which integrated Maslow’s five levels of basic human needs. According to older adults’ self-reported scores, the most important needs were physiological needs, followed by advanced needs and social needs. A regression analysis showed that the advanced needs and social needs significantly influence older adults’ use intention of assistive social robots. The results can assist in the future design of assistive social robot functions and features targeting the older population.
Similarity-Aware Architecture/Compiler Co-Designed Context-Reduction Framework for Modulo-Scheduled CGRA
Authors: Zhao Zhongyuan , Sheng Weiguang , Li Jinchao , Ye Pengfei , Wang Qin , Mao Zhigang
Published: September 2021

Modulo-scheduled coarse-grained reconfigurable array (CGRA) processors have shown their potential for exploiting loop-level parallelism at high energy efficiency. However, these CGRAs need frequent reconfiguration during their execution, which makes them suffer from large area and power overhead for context memory and context-fetching. To tackle this challenge, this paper uses an architecture/compiler co-designed method for context reduction. From an architecture perspective, we carefully partition the context into several subsections and only fetch the subsections that are different to the former context word whenever fetching the new context. We package each different subsection with an opcode and index value to formulate a context-fetching primitive (CFP) and explore the hardware design space by providing the centralized and distributed CFP-fetching CGRA to support this CFP-based context-fetching scheme. From the software side, we develop a similarity-aware tuning algorithm and integrate it into state-of-the-art modulo scheduling and memory access conflict optimization algorithms. The whole compilation flow can efficiently improve the similarities between contexts in each PE for the purpose of reducing both context-fetching latency and context footprint. Experimental results show that our HW/SW co-designed framework can improve the area efficiency and energy efficiency to at most 34% and 21% higher with only 2% performance overhead.
Could Avatar Therapy Enhance Mental Health in Chronic Patients? A Systematic Review
Authors: Franco Marta , Monfort Carlos , Piñas-Mesa Antonio , Rincon Esther
Published: September 2021

The use of avatars in the psychological treatment of some chronic diseases is in their infancy, and it represents a growing field of research with many possibilities for innovation. However, there is a lack of studies seeking to determine if avatar-based therapies could improve mental health in chronic care settings. In fact, to the best of our knowledge, this is the first systematic review addressing this research topic. The objectives of this study were to review the scientific literature on those studies involving avatar-based therapies for chronic patients, as well as different ways to develop them and their efficacy on mental health outcomes. Two main questions were addressed: (1) Are avatar-based strategies useful to improve mental health in chronic patients? (2) Which is the best way to develop avatar-based strategies regarding chronic diseases? A systematic review of the peer-reviewed literature was conducted in March 2021. The results were, not only useful for establishing suitable ways to develop avatar-based strategies to improve mental health in chronic care, but also for providing an ad hoc taxonomy regarding this research topic. Five modalities were established according to technological complexity and avatar presentation. Most of the studies were effective (61.1%) in enhancing mental health in chronic care.
A 0.2-Terahertz Ceramic Relic Detection System Based on Iterative Threshold Filtering Imaging and Neural Network
Authors: Mao Yiqing , Wu Tianxiang , Chen Yong , Ma Shunli
Published: September 2021

Ceramic cultural relics have an important cultural value, and their detection technology plays a pivotal role in the protection of cultural relics. The traditional detection method of ceramic relics is based on X-ray technology, resulting in damage to the cultural relics. The terahertz-wave transmission is nondestructive; yet, the terahertz imaging has several technical problems, such as complex algorithms and unclear imaging. In this paper, we propose a terahertz-wave imaging system of a 0.2-terahertz operating frequency with a single input and single output and perform the transmission imaging experiment of the ceramic container. This design adopts the iterative threshold segmentation imaging method to obtain the high-quality transmission image and the neural network algorithm in the imaging recognition. Both the imaging and identification results effectively prove excellent performance, such as the high efficiency, high precision, and good reliability of the nondestructive testing system for the ceramic relics. The resolution can reach 2 mm, and the time for imaging identification can be <10 s, which will provide support for the nondestructive testing of ceramic cultural relics.
Design and Realization of an Inductive Power Transfer for Shuttles in Automated Warehouses
Authors: Ceraolo Massimo , Consolo Valentina , Di Monaco Mauro , Lutzemberger Giovanni , Musolino Antonino , Rizzo Rocco , Tomasso Giuseppe
Published: September 2021

The inductive power transfer (IPT) is expected to greatly contribute towards electrification in transportation. In fact, IPT charging technology has the potential to overcome several limitations of conductive charging: in particular, the process can be fully automatable, and both static and dynamic charging are allowed, thus reducing the size of the battery pack. Additionally, safety is increased due to the absence of safety issues related to loss of cable insulation or to the unwanted interruption of the plug-socket connection. This paper presents, from a systematic approach, the design and realization of a prototype for IPT charging of autonomous shuttles in automated warehouses. First of all, the typical mission profile of the shuttle was properly identified, and a storage system based on power-oriented electrochemical cells was sized. Based on that, the architecture of the IPT system was chosen, both for transmitting and receiving sections. The pads were designed for this purpose, by considering the geometric constraints imposed by the manufacturer, through the utilization of the finite elements method. Finally, the power electronic circuitry was also designed. Numerical simulations of the components, as well as of the complete system, were performed and a prototype was built to widely verify the correspondence of the simulation outputs with the results obtained from an experimental measurements campaign.
Cost–Benefit Analysis of Solar Thermal Plants with Storage in a Hydrothermal System
Authors: Trama Cibelle Pereira , Pereira Júnior Amaro Olímpio , Guimarães Ana Paula Cardoso , Diniz André Luiz , Vieira Leonardo dos Santos Reis
Published: September 2021

Economic feasibility studies of concentrated solar power (CSP) plants with thermal energy storage (TES) systems have been mainly based on the levelized cost of electricity (LCOE), disregarding the economic benefits to the electricity system resulting from the dispatchability of the CSP plants. The analysis of these benefits is essential since the existence of storage can provide greater operating flexibility to the system. Although there are few studies on the benefits of CSP plants in thermoelectric systems, this analysis has not yet been done in a predominantly hydroelectric system. In this paper, CSP plants with TES systems were inserted in a hydrothermal system in order to estimate the economic benefits and the net cost of electricity generated by those plants. The System Advisor Model (SAM) and the hydrothermal scheduling model DESSEM were used in a real case study of inclusion of CSP plants in the Brazilian system. The results indicate that the cost of a CSP plant, previously estimated by the LCOE, can be reduced by at least 37% when considering its benefits to a hydrothermal system, increasing its competitiveness with other technologies. Therefore, we propose the use of the net cost for an appropriate comparison among energy sources.
Waste Heat Driven Multi-Ejector Cooling Systems: Optimization of Design at Partial Load; Seasonal Performance and Cost Evaluation
Authors: Viscito Luca , Lillo Gianluca , Napoli Giovanni , Mauro Alfonso William
Published: September 2021

In this paper, a seasonal performance analysis of a hybrid ejector cooling system is carried-out, by considering a multi-ejector pack as expansion device. A 20 kW ejector-based chiller was sized to obtain the optimal tradeoff between performance and investment costs. The seasonal performance of the proposed solution was then evaluated through a dynamic simulation able to obtain the performance of the designed chiller with variable ambient temperatures for three different reference climates. The optimized multi-ejector system required three or four ejectors for any reference climate and was able to enhance the system performance at partial load, with a significant increase (up to 107%) of the seasonal energy efficiency ratio. The proposed system was then compared to conventional cooling technologies supplied by electric energy (electrical chillers EHP) or low-grade heat sources (absorption chillers AHP) by considering the total costs for a lifetime of 20 years and electric energy-specific costs for domestic applications from 0.10 to 0.50 €/kWhel. The optimized multi-ejector cooling system presented a significant convenience with respect to both conventional technologies. For warmer climates and with high electricity costs, the minimum lifetime for the multi-ejector system to achieve the economic break-even point could be as low as 1.9 years.
Editorial to the Special Issue “AI Applications to Power Systems”
Authors: Lie Tek-Tjing
Published: September 2021

This Special Issue consists of the successful invited submissions to Energies on the very topical subject area of “AI applications to power systems”.
Implementation of “Smart” Solutions and An Attempt to Measure Them: A Case Study of Czestochowa, Poland
Authors: Biadacz Renata , Biadacz Marek
Published: September 2021

The aim of the study is to present the implemented “smart” solutions and the developed indicators of their measurement in the context of the city of Częstochowa (Poland), as well as a participant in the “Benchmarking—we are looking for the best smart city solutions”. In order to achieve the assumed goal, a traditional review of the literature on the subject in the field of “smart city” was carried out. Then, the methodological assumptions related to developing a model set of indicators for cities participating in the program have been presented. In addition, a comparative analysis of the obtained indicators values for cities, Częstochowa and Bydgoszcz, has been carried out in the scope of one exemplary measure. The proposed research procedure can be used to analyze and evaluate cities in the country, as well as to select alternative solutions in the context of other urban features. Due to the fact that other cities in Poland will also participate in the study, the significance of this work will have a wide impact. The research presented in the article is only a part of an intended larger initiative in which several dozen Polish cities will take part.
Combining Optical Microscopy and X-ray Computed Tomography Reveals Novel Morphologies and Growth Processes of Methane Hydrate in Sand Pores
Authors: Le Thi Xiu , Bornert Michel , Brown Ross , Aimedieu Patrick , Broseta Daniel , Chabot Baptiste , King Andrew , Tang Anh Minh
Published: September 2021

Understanding the mechanisms involved in the formation and growth of methane hydrate in marine sandy sediments is crucial for investigating the thermo-hydro-mechanical behavior of gas hydrate marine sediments. In this study, high-resolution optical microscopy and synchrotron X-ray computed tomography were used together to observe methane hydrate growing under excess gas conditions in a coarse sandy sediment. The high spatial and complementary temporal resolutions of these techniques allow growth processes and accompanying redistribution of water or brine to be observed over spatial scales down to the micrometre—i.e., well below pore size—and temporal scales below 1 s. Gas hydrate morphological and growth features that cannot be identified by X-ray computed tomography alone, such as hollow filaments, were revealed. These filaments sprouted from hydrate crusts at water–gas interfaces as water was being transported from their interior to their tips in the gas (methane), which extend in the µm/s range. Haines jumps are visualized when the growing hydrate crust hits a water pool, such as capillary bridges between grains or liquid droplets sitting on the substrate—a capillary-driven mechanism that has some analogy with cryogenic suction in water-bearing freezing soils. These features cannot be accounted for by the hydrate pore habit models proposed about two decades ago, which, in the absence of any observation at pore scale, were indeed useful for constructing mechanical and petrophysical models of gas hydrate-bearing sediments.
Use of Renewable Energy Sources in the European Union and the Visegrad Group Countries—Results of Cluster Analysis
Authors: Kacperska Elżbieta , Łukasiewicz Katarzyna , Pietrzak Piotr
Published: September 2021

Increasing the use of renewable energy sources is one of the strategic objectives of the European Union. In this regard, it seems necessary to answer the question: which of the member countries are the most effective in its implementation? Therefore, the main goal was to distinguish groups of European Union countries, including the Visegrad Group, differing in the use of renewable energy sources in transport, electricity, heating and cooling (based on cluster analysis). All members of the EU were determinedly selected for research on 1 February 2020 (27 countries). The research period embraced the years 2009–2019. The sources of materials were the literature on the topic and data from Eurostat. Descriptive, tabular, graphical methods and cluster analysis were used in the presentation and analysis of materials. In 2019 wind and hydro power accounted for two-thirds of the total electricity generated from renewable sources. In 2019, renewable energy sources made up 34% of gross electricity consumption in the EU-27. Wind and hydro power accounted for two-thirds of the total electricity generated from renewable sources (35% each). Moreover, it was determined that there were 5 clusters that differed in their use of renewable energy sources. The highest average renewable energy consumption in transport, heating and cooling in 2019 was characterized by a cluster consisting of Sweden and Finland. In contrast, the highest average renewable energy consumption in electricity was characterized by a cluster consisting of countries such as: Austria, Croatia, Denmark, Latvia and Portugal. Finally, in a group that included countries such as Belgium, France, Luxembourg, Malta, the Netherlands and the entire VG (Hungary, Czechia, Slovakia and Poland), renewable energy consumption rates (in transport, electricity, heating and cooling) were lower than the EU average (27 countries).
A Comparative Study of Power Mixes for Green Growth: How South Korea and Japan See Nuclear Energy Differently
Authors: Lim Eunjung
Published: September 2021

South Korea and Japan are two large contributors to global greenhouse gas emissions. In October 2020, President Moon Jae-in and Prime Minister Suga Yoshihide declared that their countries would aim for carbon neutrality by 2050. The Moon administration presented the Korean version of the New Deal that includes its Green New Deal, whereas the Suga administration completed its strategy aiming for green growth. Both countries emphasize the importance of energy transition through the expansion of green energy in power generation. However, they show some significant differences in dealing with nuclear energy. The purpose of this article is to compare the two countries’ energy policies and analyze the rationales and political dynamics behind their different approaches to nuclear energy. The study reveals that the contrast between the two political systems has resulted in differences between their policies. This study depends on comparative methods that use primary sources, such as governmental documents and reports by local news media.
Combining Dual Fluidized Bed and High-Temperature Gas-Cooled Reactor for Co-Producing Hydrogen and Synthetic Natural Gas by Biomass Gasification
Authors: Zhou Yangping , Gu Zhengwei , Dong Yujie , Xu Fangzhou , Zhang Zuoyi
Published: September 2021

Biomass gasification to produce burnable gas now attracts an increasing interest for production flexibility in the renewable energy system. However, the biomass gasification technology using dual fluidized bed which is most suitable for burnable gas production still encounters problems of low production efficiency and high production cost. Here, we proposed a large-scale biomass gasification system to combine dual fluidized bed and high-temperature gas-cooled reactor (HTR) for co-production of hydrogen and synthetic natural gas (SNG). The design of high-temperature gas-cooled reactor biomass gasification (HTR-BiGas) consists of one steam supply module to heat inlet steam of the gasifier by HTR and ten biomass gasification modules to co-produce 2000 MWth hydrogen and SNG by gasifying the unpretreated biomass. Software for calculating the mass and energy balances of biomass gasification was developed and validated by the experiment results on the Gothenburg biomass gasification plant. The preliminary economic evaluation showed that HTR-BiGas and the other two designs, electric auxiliary heating and increasing recirculated product gas, are economically comparative with present mainstream production techniques and the imported natural gas in China. HTR-BiGas is the best, with production costs of hydrogen and SNG around 1.6 $/kg and 0.43 $/Nm3, respectively. These designs mainly benefit from proper production efficiencies with low fuel-related costs. Compared with HTR-BiGas, electric auxiliary heating is hurt by the higher electric charge and the shortcoming of increasing recirculated product gas is its lower total production. Future works to improve the efficiency and economy of HTR-BiGas and to construct related facilities are introduced.
Research on Exhaust Emissions in Dynamic Operating States of a Combustion Engine in a Real Driving Emissions Test
Authors: Andrych-Zalewska Monika , Chlopek Zdzislaw , Merkisz Jerzy , Pielecha Jacek
Published: September 2021

The paper describes the method of investigations of exhaust emissions from a combustion engine under operation classified in terms of its dynamic states. In this paper, the engine operating states are determined through the vehicle driving under actual traffic conditions in the RDE (Real Driving Emissions) test. Based on the recorded tracings of the vehicle velocity, the engine states were classified as static for the acceleration of the absolute value lower than the adopted classification limit. Besides, the authors analyzed the engine operating states for the positive as well as negative acceleration. For the adopted engine operating states, zero-dimensional characteristics of the emission intensity for individual exhaust components were determined (average value, coefficient of variation). The influence of the analyzed operating states on the emission of individual exhaust components was assessed. The greatest increase in the intensity of the emission of nitrogen oxides was observed for the positive vehicle acceleration model and the lowest (also for the nitrogen oxides) for the negative vehicle acceleration. On average, the greatest increase in the emission intensity of pollutants and the intensity of particle number occurred for the dynamic states of the engine corresponding to positive acceleration. The conclusions from the performed investigations entitle the authors to propose a greater allowance for the exhaust emission-related criteria in the engine control algorithms.
An Overview of the Classification, Production and Utilization of Biofuels for Internal Combustion Engine Applications
Authors: Awogbemi Omojola , Kallon Daramy Vandi Von , Onuh Emmanuel Idoko , Aigbodion Victor Sunday
Published: September 2021

Biofuel, a cost-effective, safe, and environmentally benign fuel produced from renewable sources, has been accepted as a sustainable replacement and a panacea for the damaging effects of the exploration for and consumption of fossil-based fuels. The current work examines the classification, generation, and utilization of biofuels, particularly in internal combustion engine (ICE) applications. Biofuels are classified according to their physical state, technology maturity, the generation of feedstock, and the generation of products. The methods of production and the advantages of the application of biogas, bioalcohol, and hydrogen in spark ignition engines, as well as biodiesel, Fischer–Tropsch fuel, and dimethyl ether in compression ignition engines, in terms of engine performance and emission are highlighted. The generation of biofuels from waste helps in waste minimization, proper waste disposal, and sanitation. The utilization of biofuels in ICEs improves engine performance and mitigates the emission of poisonous gases. There is a need for appropriate policy frameworks to promote commercial production and seamless deployment of these biofuels for transportation applications with a view to guaranteeing energy security.
Chemometrics in Tandem with Hyperspectral Imaging for Detecting Authentication of Raw and Cooked Mutton Rolls
Authors: Jiang Hongzhe , Yang Yi , Shi Minghong
Published: September 2021

Authentication assurance of meat or meat products is critical in the meat industry. Various methods including DNA- or protein-based techniques are accurate for assessing meat authenticity, however, they are destructive, expensive, or laborious. This study explores the feasibility of chemometrics in tandem with hyperspectral imaging (HSI) for identifying raw and cooked mutton rolls substitution by pork and duck rolls. Raw or cooked samples (n = 180) of three meat species were prepared to collect hyperspectral images in range of 400–1000 nm. Spectra were extracted from representative regions of interest (ROIs), and spectral principal component analysis (PCA) revealed that PC1 and PC2 were effective for the identification. Different methods including standard normal variable (SNV), first and second derivatives, and normalization were individually employed for spectral preprocessing, and modeling methods of partial least squares-discriminant analysis (PLS-DA) and support vector machines (SVM) were also individually applied to develop classification models for both the raw and the cooked. Results showed that PLS-DA model developed by raw spectra presented the highest 100% correct classification rate (CCR) of success in all sets. After that, effective wavelengths selected by successive projections algorithm (SPA) built optimal simplified models which didn’t influence the modeling results compared with full spectra regardless of the meat roll states. Therefore, SPA-PLS-DA models were subsequently used to visualize the raw and cooked meat rolls classification. As a consequence, the general meat species of both raw and cooked meat rolls were readily discernible in pixel-wise manner by generating classification maps. The results showed that HSI combined with chemometrics can be used to identify the authentication of raw and cooked mutton rolls substituted by pork and duck rolls accurately. This promising methodology provides a reference which can be extended to the classification or grading of other meat rolls.
Authentication of Geographical Origin in Hainan Partridge Tea (Mallotus obongifolius) by Stable Isotope and Targeted Metabolomics Combined with Chemometrics
Authors: Fu Jiashun , Yu Hai-Dong , Wu Long , Zhang Chenghui , Yun Yong-Huan , Zhang Weimin
Published: September 2021

Partridge tea (Mallotus oblongifolius (Miq.) Müll.Arg.) is a local characteristic tea in Hainan, the southernmost province of China, and the quality of partridge tea may be affected by the producing areas. In this study, stable isotope and targeted metabolomics combined chemometrics were used as potential tools for analyzing and identifying partridge tea from different origins. Elemental analysis—stable isotope ratio mass spectrometer and liquid chromatography-tandem mass spectrometrywas used to analyze the characteristics of C/N/O/H stable isotopes and 54 chemical components, including polyphenols and alkaloids in partridge tea samples from four regions in Hainan (Wanning, Wenchang, Sanya and Baoting). The results showed that there were significant differences in the stable isotope ratios and polyphenol and alkaloid contents of partridge tea from different origins, and both could accurately classify partridge tea from different origins. The correct separation and clustering of the samples were observed by principal component analysis and the cross-validated Q2 values by orthogonal partial least squares discriminant analysis (OPLS-DA) were 0.949 (based on stable isotope) and 0.974 (based on polyphenol and alkaloid), respectively. Potential significance indicators for origin identification were screened out by OPLS-DA and random forest algorithm, including three stable isotopes (δ13C, δ D, and δ18O) and four polyphenols (luteolin, protocatechuic acid, astragalin, and naringenin). This study can provide a preliminary guide for the origin identification of Hainan partridge tea.
Optimisation of Stingless Bee Honey Nanoemulsions Using Response Surface Methodology
Authors: Rozman Azri Shahir , Hashim Norhashila , Maringgal Bernard , Abdan Khalina
Published: September 2021

Nanoemulsions (NEs) have been used in a wide range of products, such as those produced by the food, cosmetics, and pharmaceutical industries, due to their stability and long shelf life. In the present study, stingless bee honey (SBH) NEs were formulated using SBH, oleic acid, tween 80, glycerol, and double-distilled water. SBH NEs were prepared using a high-pressure homogeniser and were characterised by observing their stability and droplet size. Fourier Transform-Infrared (FTIR) analysis was used to observe the functional groups of the SBH NEs after being subjected to high-pressure homogenisation. Transmission Electron Microscopy (TEM) images were then used to confirm the particle size of the SBH NEs and to investigate their morphology. The effects of the independent variables (percentage of oleic acid, storage time, and storage temperature) on the response variables (particle size and polydispersity index) were investigated using the response surface methodology, along with a three-level factorial design. The results showed that the models developed via the response surface methodology were reliable, with a coefficient of determination (R2) of more than 0.90. The experimental validation indicated an error of less than 10% in the actual results compared to the predicted results. The FTIR analysis showed that SBH NEs have the same functional group as SBH. Observation through TEM indicated that the SBH NEs had a similar particle size, which was between 10 and 100 nm. Thus, this study shows that SBH NEs can be developed using a high-pressure homogeniser, which indicates a new direction for SBH by-products.
Time Course Analysis of Genome-Wide Identification of Mutations Induced by and Genes Expressed in Response to Carbon Ion Beam Irradiation in Rice (Oryza sativa L.)
Authors: Zhang Jian , Peng Ziai , Liu Qiling , Yang Guili , Zhou Libin , Li Wenjian , Wang Hui , Chen Zhiqiang , Guo Tao
Published: September 2021

Heavy-ion irradiation is a powerful mutagen and is widely used for mutation breeding. In this study, using whole-genome sequencing (WGS) and RNA sequencing (RNA-seq) techniques, we comprehensively characterized these dynamic changes caused by mutations at three time points (48, 96, and 144 h after irradiation) and the expression profiles of rice seeds irradiated with C ions at two doses. Subsequent WGS analysis revealed that more mutations were detected in response to 40 Gy carbon ion beam (CIB) irradiation than 80 Gy of CIB irradiation at the initial stage (48 h post-irradiation). In the mutants generated from both irradiation doses, single-base substitutions (SBSs) were the most frequent type of mutation induced by CIB irradiation. Among the mutations, the predominant ones were C:T and A:G transitions. CIB irradiation also induced many short InDel mutations. RNA-seq analysis at the three time points showed that the number of differentially expressed genes (DEGs) was highest at 48 h post-irradiation. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of the DEGs showed that the “replication and repair” pathway was enriched specifically 48 h post-irradiation. These results indicate that the DNA damage response (DDR) and the mechanism of DNA repair tend to quickly start within the initial stage (48 h) after irradiation.
Attitudes toward Female Genital Mutilation/Circumcision: A Systematic Review and Meta-Analysis
Authors: Jahangiry Leila , Pashaei Tahereh , Ponnet Koen
Published: September 2021

Background: Understanding the attitudes toward FGM/C held by people who have been involved in this practice can lead to more active interventions to prevent this harmful practice. In order to achieve this, a systematic review was performed on scientific articles. Methods: Electronic databases (PubMed, Scopus, and Science Direct) were examined to identify articles. Results: Our initial search resulted in 3013 articles, of which 40 articles with estimations of attitudes toward FGM/C were reviewed. The results indicate that the random-effects pooled estimation of negative attitudes toward FGM/C practice was 53% (95% CI 47–59; p < 0.001). Furthermore, the pooled estimation of attitudes toward the decision not to circumcise young daughters was 63% (95% CI 46–80; p < 0.001). Conclusion: Despite the increased awareness and efforts to ban FGM/C in many countries around the world, our review demonstrates that positive attitudes toward FGM/C are still far from being eradicated and have hardly changed in the past years. This issue reflects deeply rooted cultural and social concerns of health care professionals with regard to continuing the practice. The authors believe that circumcised women can play a key role in encouraging the abandonment of FGM/C through educational and cultural campaigns.
A Backward Walking Training Program to Improve Balance and Mobility in Children with Cerebral Palsy
Authors: Choi Ji-Young , Son Sung-Min , Park Se-Hee
Published: September 2021

Background: We studied the effects of motor tasks using backward walking training on balance and gait functions of children with cerebral palsy. This was a single-blinded, randomized controlled trial with a crossover design conducted at a single facility. Methods: Among 12 children with cerebral palsy, the forward (FWG) (n = 6) and backward walking groups (BWG) (n = 6) underwent training three times a week for 4 weeks, 40 min a day. After a 6-week break, the crossover training was conducted. Functional walking variables were measured. Time-Up-and-Go (TUG) test, Figure-8 Walk Test (FW8T), and Pediatric Balance Scale (PBS) were used for measuring balance. Results: Both groups showed significant improvement in walking speed, stride length, and step length. The BWG demonstrated significant improvement in walking speed (p < 0.05) compared with the FWG. The TUG test, FW8T, and PBS showed significant improvement. After the 4-week intervention, both groups displayed a remarkable decrease in TUG duration and FW8T. Both groups also exhibited improvement in the PBS; more so in the BWG. Conclusions: Backward walking training with motor dual tasks could be a more effective interventional approach than forward walking training to improve balance and walking functions of children with spastic hemiplegia.
Wastewater Valorization: Practice around the World at Pilot- and Full-Scale
Authors: Duque Anouk F. , Campo Riccardo , Val del Rio Angeles , Amorim Catarina L.
Published: September 2021

Over the last few years, wastewater treatment plants (WWTPs) have been rebranded as water resource recovery facilities (WRRFs), which recognize the resource recovery potential that exists in wastewater streams. WRRFs contribute to a circular economy by not only producing clean water but by recovering valuable resources such as nutrients, energy, and other bio-based materials. To this aim, huge efforts in technological progress have been made to valorize sewage and sewage sludge, transforming them into valuable resources. This review summarizes some of the widely used and effective strategies applied at pilot- and full-scale settings in order to valorize the wastewater treatment process. An overview of the different technologies applied in the water and sludge line is presented, covering a broad range of resources, i.e., water, biomass, energy, nutrients, volatile fatty acids (VFA), polyhydroxyalkanoates (PHA), and exopolymeric substances (EPS). Moreover, guidelines and regulations around the world related to water reuse and resource valorization are reviewed.
Inequality-Reducing Effects of Tobacco Tax Increase: Accounting for Behavioral Response of Low-, Middle-, and High-Income Households in Serbia
Authors: Vladisavljević Marko , Zubović Jovan , Đukić Mihajlo , Jovanović Olivera
Published: September 2021

While previous research has indicated that increasing tobacco excises is a crucial instrument for lowering tobacco demand, this policy has been criticized for its alleged regressive impact on the poor. However, this critique does not take into account the behavioral response, i.e., decrease in consumption that occurs after excises and prices increase. In this paper, we examine the effect of cigarettes’ price increase on tobacco consumption, household expenditures, and tax burdens in three income groups and provide empirical arguments on the regressivity/progressivity effects of tobacco tax increase. Estimated elasticities indicate that all groups decrease their cigarettes demand with increasing prices, with demand decrease stronger for low- than for middle- and high-income households. Results further suggest that increasing tobacco excises (1) decreases tobacco expenditure of low-income households, which increases their productive consumption, such as on food, clothes, etc., and (2) redistributes the tobacco tax burden from low- to high-income households. Therefore, excise increase policies do not have an adverse effect on the position of the low-income households; on the contrary, they lower their cigarettes expenditure and their tax burden, while lower cigarettes consumption has an additional, positive effect on their health, which attenuates future inequalities.
Assessing the Quality of Life of Oral Submucous Fibrosis Patients: A Cross-Sectional Study Using the WHOQOL-BREF Tool
Authors: Memon Abdul Bari , Rahman Aneela Atta Ur , Channar Kashif Ali , Zafar Muhammad Sohail , Kumar Naresh
Published: September 2021

The aim of the present study was to evaluate the quality of life (QoL) of oral submucous fibrosis (OSMF) patients using the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire. This cross-sectional study was conducted at the Department of Oral and Maxillofacial Surgery, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro. We used the consecutive sampling technique to recruit patients who were clinically diagnosed with OSMF (n = 112). Data were collected using the WHOQOL-BREF questionnaire, which contains a total of 26 questions. The first two questions, related to overall QoL and overall health status, were evaluated separately. The remaining questions (3–26), which represented four domains—physical, psychological, social, and environmental health—were evaluated separately. Patients were asked questions in their native language (Urdu). The relationship between these four domains of life was evaluated with gender, age categories, functional staging, and habit duration using the independent t-test to determine statistical significance. Cronbach’s Alpha was used to assess the reliability of the WHOQOL-BREF domains. The overall QoL of the OSMF patients was considerably poor, and the majority of the patients were unsatisfied with their oral health status. The age variable significantly affected the scores of all domains except for social relationships, whereas habit duration and functional staging of OSMF did not significantly affect the scores of all domains. The domains of the WHOQOL-BREF questionnaire (translated into the Urdu language) showed good reliability, except for social relationships.
Promotion of Mental Health Literacy in Adolescents: A Scoping Review
Authors: Nobre Joana , Oliveira Ana Paula , Monteiro Francisco , Sequeira Carlos , Ferré-Grau Carme
Published: September 2021

In recent years, there has been an important commitment to the development of programs to promote mental health literacy (MHL) among adolescents, due to the prevalence of mental health problems and the low level of MHL that affects this group. The aim of this study was to map the structure and context of programmes/interventions for promoting MHL among adolescents in school settings. A scoping review was conducted following the guidelines of The Joanna Briggs Institute. We searched for studies on programmes/interventions promoting at least one of the components of MHL of adolescents, written in Portuguese, English or Spanish, published from 2013 to 2020, in MEDLINE, CINAHL Plus with Full Text, SciELO, SCOPUS, OpenGrey, RCAAP and in the article reference lists. This review included 29 articles. The majority of programmes/interventions addressed one or more of the four components of MHL, with the knowledge of mental disorders and stigma reduction components being the most covered; were taught by adolescent’s regular teachers; used face to face interventions; had a height variable duration; used non-validated instruments; were implemented in a classroom environment; and showed statistically significant improvements in adolescent’s MHL levels. More research is needed to implement/construct programmes/interventions promoting adolescents’ MHL concerning knowledge on how to obtain and maintain good mental health.