bluuebunny/crossref_metadata_2025 huggingface dataset:
Failure to Control Hyperglycemia in NonCritically Ill Diabetes Patients despite Standard Glycemic Management in a Hospital Setting
Authors: Neubauer Katharina Maria , Schaupp Lukas , Plank Johannes , Augustin Thomas , Mautner Selma Isabella , Tschapeller Bernd , Pieber Thomas Rudolf
Published: January 2014

Background:

Successful control of hyperglycemia has been shown to improve outcomes for diabetes patients in a clinical setting. We assessed the quality of physician-based glycemic management in two general wards, considering the most recent recommendations for glycemic control for noncritically ill patients (<140 mg/dl for premeal glucose).

Methods:

Quality of glycemic management of 50 patients in two wards (endocrinology, cardiology) was assessed retrospectively by analyzing blood glucose (BG) levels, the glycemic management effort, and the online questionnaire.

Results:

Glycemic control was clearly above the recommended target (mean BG levels: Endocrinology: 175 ± 62 mg/dl; cardiology: 186 ± 68 mg/dl). When comparing the first half with the second half of the hospital stay, we found no difference in glycemic control (endocrinology: 168 ± 32 vs 164 ± 42 mg/dl, P = .67; cardiology: 174 ± 36 mg/dl vs 170 ± 42 mg/dl, P =.51) and in insulin dose (endocrinology: 15 ± 14 IU vs 15 ± 13 IU per day, P = .87; cardiology: 27 ± 17 IU vs 27 ± 18 IU per day, P = .92), despite frequent BG measurements (endocrinology: 2.7 per day; cardiology: 3.2 per day). A lack of clearly defined BG targets was indicated in the questionnaire.

Conclusion:

The recommended BG target range was not achieved in both wards. Analysis of routine glycemic management demonstrated considerable glycemic management effort, but also a lack of translation into adequate insulin therapy. Implementation of corrective measures, such as structured treatment protocols, is essential.
An Apparatus to Quantify Anteroposterior and Mediolateral Shear Reduction in Shoe Insoles
Authors: Belmont Barry , Wang Yancheng , Ammanath Peethambaran , Wrobel James S. , Shih Albert
Published: January 2014

Background:

Many of the physiological changes that lead to diabetic foot ulceration, such as muscle atrophy and skin hardening, are manifested at the foot-ground interface via pressure and shear points. Novel shear-reducing insoles have been developed, but their magnitude of shear stiffness has not yet been compared with regular insoles. The aim of this study was to develop an apparatus that would apply shear force and displacement to an insole's forefoot region, reliably measure deformation, and calculate insole shear stiffness.

Methods:

An apparatus consisting of suspended weights was designed to test the forefoot region of insoles. Three separate regions representing the hallux; the first and second metatarsals; and the third, fourth, and fifth metatarsals were sheared at 20 mm/min for displacements from 0.1 to 1.0 mm in both the anteroposterior and mediolateral directions for two types of insoles (regular and shear reducing).

Results:

Shear reduction was found to be significant for the intervention insoles under all testing conditions. The ratio of a regular insole's effective stiffness and the experimental insole's effective stiffness across forefoot position versus shear direction, gait instance versus shear direction, and forefoot position versus gait instance was 270% ± 79%, 270% ± 96%, and 270% ± 86%, respectively. The apparatus was reliable with an average measured coefficient of variation of 0.034 and 0.069 for the regular and shear-reducing insole, respectively.

Conclusion:

An apparatus consisting of suspended weights resting atop three locations of interest sheared across an insole was demonstrated to be capable of measuring the insole shear stiffness accurately, thus quantifying shear-reducing effects of a new type of insole.
Self-Monitoring of Blood Glucose in Type 2 Diabetes: Recent Studies
Authors: Schnell Oliver , Alawi Hasan , Battelino Tadej , Ceriello Antonio , Diem Peter , Felton Anne-Marie , Grzeszczak Wladyslaw , Harno Kari , Kempler Peter , Satman Ilhan , Vergès Bruno
Published: January 2014

The increasing role for structured and personalized self-monitoring of blood glucose (SMBG) in management of type 2 diabetes has been underlined by randomized and prospective clinical trials. These include Structured Testing Program (or STeP), St. Carlos, Role of Self-Monitoring of Blood Glucose and Intensive Education in Patients with Type 2 Diabetes Not Receiving Insulin, and Retrolective Study Self-Monitoring of Blood Glucose and Outcome in Patients with Type 2 Diabetes (or ROSSO)-in-praxi follow-up. The evidence for the benefit of SMBG both in insulin-treated and non-insulin-treated patients with diabetes is also supported by published reviews, meta-analyses, and guidelines. A Cochrane review reported an overall effect of SMBG on glycemic control up to 6 months after initiation, which was considered to subside after 12 months. Particularly, the 12-month analysis has been criticized for the inclusion of a small number of studies and the conclusions drawn. The aim of this article is to review key publications on SMBG and also to put them into perspective with regard to results of the Cochrane review and current aspects of diabetes management.
Blood Glucose Measurement in the Intensive Care Unit: What is the Best Method?
Authors: Le Huong T. , Harris Neil S. , Estilong Abby J. , Olson Arvid , Rice Mark J.
Published: January 2014

Abnormal glucose measurements are common among intensive care unit (ICU) patients for numerous reasons and hypoglycemia is especially dangerous because these patients are often sedated and unable to relate the associated symptoms. Additionally, wide swings in blood glucose have been closely tied to increased mortality. Therefore, accurate and timely glucose measurement in this population is critical. Clinicians have several choices available to assess blood glucose values in the ICU, including central laboratory devices, blood gas analyzers, and point-of-care meters. In this review, the method of glucose measurement will be reviewed for each device, and the important characteristics, including accuracy, cost, speed of result, and sample volume, will be reviewed, specifically as these are used in the ICU environment. Following evaluation of the individual measurement devices and after considering the many features of each, recommendations are made for optimal ICU glucose determination.
The Future is Now: Software-Guided Intensive Insulin Therapy in the Critically Ill
Authors: Rattan Rishi , Nasraway Stanley A.
Published: January 2014

Since the development of intensive insulin therapy for the critically ill adult, tight glycemic control (TGC) has become increasingly complicated to apply and achieve. Software-guided (SG) algorithms for insulin dosing represent a new method to achieve euglycemia in critical illness. We provide an overview of the state of SG TGC with an eye to the future. The current milieu is disorganized, with little research that incorporates newer variables of dysglycemia, such as glycemic variability. To develop and implement better algorithms, scientists, programmers, and clinicians need to standardize measurements and variables.
Recommendations for Standardizing Glucose Reporting and Analysis to Optimize Clinical Decision Making in Diabetes: The Ambulatory Glucose Profile
Authors: Bergenstal Richard M. , Ahmann Andrew J. , Bailey Timothy , Beck Roy W. , Bissen Joan , Buckingham Bruce , Deeb Larry , Dolin Robert H. , Garg Satish K. , Goland Robin , Hirsch Irl B. , Klonoff David C. , Kruger Davida F. , Matfin Glenn , Mazze Roger S. , Olson Beth A. , Parkin Christopher , Peters Anne , Powers Margaret A. , Rodriguez Henry , Southerland Phil , Strock Ellie S. , Tamborlane William , Wesley David M.
Published: January 2014

Underutilization of glucose data and lack of easy and standardized glucose data collection, analysis, visualization, and guided clinical decision making are key contributors to poor glycemic control among individuals with type 1 diabetes mellitus. An expert panel of diabetes specialists, facilitated by the International Diabetes Center and sponsored by the Helmsley Charitable Trust, met in 2012 to discuss recommendations for standardizing the analysis and presentation of glucose monitoring data, with the initial focus on data derived from continuous glucose monitoring systems. The panel members were introduced to a universal software report, the Ambulatory Glucose Profile, and asked to provide feedback on its content and functionality, both as a research tool and in clinical settings. This article provides a summary of the topics and issues discussed during the meeting and presents recommendations from the expert panel regarding the need to standardize glucose Profile summary metrics and the value of a uniform glucose report to aid clinicians, researchers, and patients.
Integration of a Mobile-Integrated Therapy with Electronic Health Records: Lessons Learned
Authors: Peeples Malinda M. , Iyer Anand K. , Cohen Joshua L.
Published: January 2014

Background:

Responses to the chronic disease epidemic have predominantly been standardized in their approach to date. Barriers to better health outcomes remain, and effective management requires patient-specific data and disease state knowledge be presented in methods that foster clinical decision-making and patient self-management. Mobile technology provides a new platform for data collection and patient-provider communication. The mobile device represents a personalized platform that is available to the patient on a 24/7 basis. Mobile-integrated therapy (MIT) is the convergence of mobile technology, clinical and behavioral science, and scientifically validated clinical outcomes. In this article, we highlight the lessons learned from functional integration of a Food and Drug Administration-cleared type 2 diabetes MIT into the electronic health record (EHR) of a multiphysician practice within a large, urban, academic medical center.

Methods:

In-depth interviews were conducted with integration stakeholder groups: Mobile and EHR software and information technology teams, clinical end users, project managers, and business analysts. Interviews were summarized and categorized into lessons learned using the Architecture for Integrated Mobility® framework.

Results:

Findings from the diverse stakeholder group of a MIT-EHR integration project indicate that user workflow, software system persistence, environment configuration, device connectivity and security, organizational processes, and data exchange heuristics are key issues that must be addressed.

Conclusions:

Mobile-integrated therapy that integrates patient self-management data with medical record data provides the opportunity to understand the potential benefits of bidirectional data sharing and reporting that are most valuable in advancing better health and better care in a cost-effective way that is scalable for all chronic diseases.
Methodology for Quantifying Fasting Glucose Homeostasis in Type 2 Diabetes: Observed Variability and Lability
Authors: Hill Nathan R. , Tsapas Apostolos , Hindmarsh Peter , Matthews David R.
Published: January 2014

Background:

Increased glycemic variability is associated with an increase risk of adverse clinical outcomes in diabetes. Central to the understanding of diabetes is glucose homeostasis. “Good” homeostasis is equated to low glycemic variability, and “poor” homeostasis is linked to greater glycemic variability. We have, therefore, developed a method with the aim to objectively quantify the domain of glucose-insulin homeostasis. We have termed this method as Observed Variability And Lability (OVAL).

Method:

Blood samples for the measurement of glucose and insulin concentrations were acquired every 2 min for 120 min from 12 patients with type 2 diabetes mellitus [T2DM; median (range) age 35 (25–47) years and duration of diabetes 7 (2–9) years receiving oral hypoglycemic treatment] and 27 controls [aged 38(30–53) years] with an equal split of genders and equal distribution of body mass indexes. The insulin-glucose time variant data form the boundaries of OVAL, defined as the ellipse enclosing the 95% confidence intervals of the insulin and glucose concentrations plotted on an x-y scatter graph and normalized to ensure equal weighting of insulin and glucose.

Results:

Less precise OVAL homeostasis was observed in subjects with T2DM, by a factor of 4, in comparison with controls [OVAL, T2DM 7.8(3.8) versus controls 1.9(1.0); p = .0003]. The assessment remained statistically robust ( p < .001) with increased sampling intervals up to 8 min.

Conclusion:

The OVAL model is a robust method for measuring glucose-insulin homeostasis in controls and T2DM subjects (available online at http://www.oval-calc.co.uk ). Deranged glucose-insulin homeostasis is the hallmark of diabetes and OVAL has the capacity to quantify in the fasting state.
Evaluation of a Minimally Invasive System for Measuring Glucose Area under the Curve during Oral Glucose Tolerance Tests: Usefulness of Sweat Monitoring for Precise Measurement
Authors: Sakaguchi Kazuhiko , Hirota Yushi , Hashimoto Naoko , Ogawa Wataru , Hamaguchi Tomoya , Matsuo Toshihiro , Miyagawa Jun-Ichiro , Namba Mitsuyoshi , Sato Toshiyuki , Okada Seiki , Tomita Koji , Matsuhisa Munehide , Kaneto Hideaki , Kosugi Keisuke , Maegawa Hiroshi , Nakajima Hiromu , Kashiwagi Atsunori
Published: January 2014

Aims:

We developed a system for measuring glucose area under the curve (AUC) using minimally invasive interstitial fluid extraction technology (MIET). Sweat contamination during interstitial fluid glucose (IG) extraction affects the accuracy of glucose AUC measurement, because this technology uses extracted sodium ion levels as an internal standard. Therefore, we developed a sweat monitoring patch to reduce this effect and investigated its efficacy in volunteers undergoing oral glucose tolerance tests (OGTTs). Materials and Methods: Fifty diabetes mellitus inpatients and 10 healthy subjects undergoing the 75 g OGTT were included. Two sites on the forearm were pretreated with microneedle arrays, then hydrogels for interstitial fluid extraction were placed on the treated sites. Simultaneously, hydrogels for sweat monitoring were placed on untreated sites near the treated sites. Plasma glucose (PG) levels were measured every 30 min for 2 h to calculate reference AUC values. Using MIET, IG AUC was calculated from extracted glucose and sodium ion levels after attachment of the hydrogel for 2 h.

Results:

Good correlation between IG AUC measurements using MIET and reference AUCs measured using PG levels was confirmed over a wide AUC range (202–610 mg/h/dl) after correction for the sweat-induced error detected by the hydrogel patches on the nonpretreated skin. Strong correlation between IG AUC and peak glucose levels indicates that glucose spikes can be easily detected by this system.

Conclusion:

We confirmed the effectiveness of a sweat monitoring patch for precise AUC measurement using MIET. This novel, easy-to-use system has potential for glucose excursion evaluation in daily clinical practice.
Applicability Results of a Nonlinear Model-Based Robust Blood Glucose Control Algorithm
Authors: Kovács Levente , Szalay Péter , Almássy Zsuzsanna , Barkai László
Published: January 2014

Introduction:

Generating optimal control algorithms for an artificial pancreas is an intensively researched problem. The available models are all nonlinear and rather complex. Model predictive control or run-to-run-based methodologies have proven to be efficient solutions for individualized treatment of type 1 diabetes mellitus (T1DM). However, the controller has to ensure safety and stability under all circumstances. Robust control methods seek to provide this safety and guarantee to handle even the worst-case situations and, hence, to generalize and complement results obtained by individualized control algorithms. Methods: Modern robust (e.g., Hinf) control is a linear model-based methodology that we have combined with the nonlinear model-based linear parameter varying technique. The control algorithm was designed on the high-complexity modified nonlinear glucose-insulin model of Sorensen, and it was compared step-by-step with linear model-based Hinf control results published in the literature. The applicability of the developed algorithm was tested first on a control cohort of 10 healthy persons' oral glucose tolerance test results and then on a large meal absorption profile adapted from the literature. In the latter case, two preliminary virtual patients were generated based on 1–1 week real continuous glucose monitor measurements.

Results:

We have found that the algorithm avoids hypoglycemia (not caused by physical activity or stress) independently from the considered absorption profiles.

Conclusion:

Use of hard constraints proved their efficiency in fitting blood glucose level within a defined interval. However, in the future, more data of different T1DM patients will be collected and tested, including dynamic absorption model and in silico tests on validated simulators.
Outcomes of a 12-Month Technology-Based Intervention to Promote Weight Loss in Adolescents at Risk for Type 2 Diabetes
Authors: Patrick Kevin , Norman Gregory J. , Davila Evelyn P. , Calfas Karen J. , Raab Fred , Gottschalk Michael , Sallis James F. , Godbole Suni , Covin Jennifer R.
Published: January 2014

Background:

Obese adolescents are at risk for type 2 diabetes mellitus (T2DM). Obesity interventions delivered through media, such as the web and text messages [short message service (SMS)] may be beneficial when targeting obese adolescents.

Methods:

A randomized controlled trial, Pace-Internet for Diabetes Prevention Intervention (PACEi-DP), compared three forms of an obesity intervention to usual care (UC): (a) website only (W); (b) website, monthly group sessions, and follow-up calls (WG); and (c) website and SMS (WSMS). Participants were overweight or obese adolescents at risk for T2DM ( n = 101; age 12–16 years; mean body mass index (BMI) percentile = 97.6; 74.3% Hispanic). In addition to the website, WSMS participants received SMS supporting intervention goals and behavioral strategies and communicated via SMS with a case manager. WG participants had additional group activities related to weight loss and received follow-up calls from a health coach. UC participants were given printed materials and encouraged to attend three initial group sessions. Repeated measures mixed model regression analyses tested treatment effects for anthropometric, behavioral, and behavioral change strategy outcomes.

Results:

There were no treatment effects for BMI, adiposity, physical activity, or diet at 12 months. Treatment effects were observed for sedentary behavior, with the W arm having a greater decrease in sedentary behavior (4.9 to 2.8 h/day) than the UC arm ( p = .006).

Conclusion:

Although not sufficient to produce weight loss, the combination of web intervention and group sessions with telephone follow-up yielded improvements in sedentary behavior and in the use of behavior change strategies expected to lead to behavior change.
Warring Identities
Authors: Smith R. Tyson , True Gala
Published: January 2014

Drawing from 26 life story interviews of recent American veterans, this paper analyzes the identity struggle faced by soldiers returning from Operation Iraqi Freedom and Operation Enduring Freedom and reentering the civilian world. Instead of examining veterans’ problems as a consequence of post-combat mental illnesses such as PTSD and major depression, we analyze the contrast between the participants’ identities as soldiers and their identities as civilians. We find that the postwar transition causes adverse mental health effects that stem from contrasts between the military’s demands for deindividuation, obedience, chain-of-command, and dissociation and the civilian identity expectations of autonomy, self-advocacy, and being relational. Veterans’ reintegration to civilian society is further hindered by a culture that is perceived (by veterans) as having decreased understanding of the soldier/veteran experience itself. These identity conflicts—what we term warring identities—have an important yet understudied effect on veterans’ combat-related mental health problems.
Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay
Authors: Lordkipanidzé Marie , Lowe Gillian C. , Kirkby Nicholas S. , Chan Melissa V. , Lundberg Martina H. , Morgan Neil V. , Bem Danai , Nisar Shaista P. , Leo Vincenzo C. , Jones Matthew L. , Mundell Stuart J. , Daly Martina E. , Mumford Andrew D. , Warner Timothy D. , Watson Steve P.
Published: January 2014

Key Points

The Optimul 96-well platelet aggregation assay has high levels of sensitivity and specificity for detecting platelet defects. The requirement for a small volume of blood, straightforward nature, and speed make Optimul a promising screening test in bleeding patients.
Analysis of TTG1 function in Arabis alpina
Authors: Chopra Divykriti , Wolff Heike , Span Johannes , Schellmann Swen , Coupland George , Albani Maria C , Schrader Andrea , Hülskamp Martin
Published: January 2014

Background

In Arabidopsis thaliana (A. thaliana) the WD40 protein TRANSPARENT TESTA GLABRA1 (TTG1) controls five traits relevant for the adaptation of plants to environmental changes including the production of proanthocyanidin, anthocyanidin, seed coat mucilage, trichomes and root hairs. The analysis of different Brassicaceae species suggests that the function of TTG1 is conserved within the family.

Results

In this work, we studied the function of TTG1 in Arabis alpina (A. alpina). A comparison of wild type and two Aattg1 alleles revealed that AaTTG1 is involved in the regulation of all five traits. A detailed analysis of the five traits showed striking phenotypic differences between A. alpina and A. thaliana such that trichome formation occurs also at later stages of leaf development and that root hairs form at non-root hair positions.

Conclusions

The evolutionary conservation of the regulation of the five traits by TTG1 on the one hand and the striking phenotypic differences make A. alpina a very interesting genetic model system to study the evolution of TTG1-dependent gene regulatory networks at a functional level.
Radiofrequency ablation following first-line transarterial chemoembolization for patients with unresectable hepatocellular carcinoma beyond the Milan criteria
Authors: Zhang Lan , Yin Xin , Gan Yu-hong , Zhang Bo-heng , Zhang Ju-bo , Chen Yi , Xie Xiao-ying , Ge Ning-lin , Wang Yan-hong , Ye Sheng-long , Ren Zheng-gang
Published: January 2014

Background

Recent studies suggest that a combination of radiofrequency ablation (RFA) and transarterial chemoembolization (TACE) may have theoretical advantages over TACE alone for treatment of hepatocellular carcinoma (HCC). The purpose of this study was to evaluate the effectiveness and safety of radiofrequency ablation following first-line TACE treatment in the management of HCC beyond the Milan Criteria.

Methods

Forty-five patients who consecutively underwent RFA following first-line TACE treatment for HCC beyond the Milan criteria were enrolled in this study. RFA was performed within 1–2 months after TACE treatment in patients who had incomplete necrotic tumor nodules. Primary effectiveness, complications, survival rates, and prognostic factors were evaluated retrospectively.

Results

Complete ablation was achieved in 76.2% of the lesions according to 1-month follow-up computed tomography/magnetic resonance imaging evaluation. The mean follow-up period was 30.9 months (range 3–94 months). There were no major complications after RFA therapy. The median overall survival was 29 months (range 20–38 months), with 1-, 2-, and 3-year survival of 89%, 61%, and 43%, respectively. Multivariate analysis revealed that tumor diameter (P = 0.045, hazard ratio [HR] = 0.228, 95% confidence interval [CI]: 0.054-0.968) and pretreatment serum alpha-fetoprotein level (P = 0.024, HR = 2.239, 95% CI: 1.114-4.500) were independent predictors for long-term survival.

Conclusions

HCC beyond the Milan criteria can be completely and safely ablated by radiofrequency ablation following first-line TACE treatment with a low rate of complications and favorable survival outcome. Further assessment of the survival benefits of combination treatment for HCCs beyond the Milan Criteria is warranted.
Rifampicin mono-resistant tuberculosis in France: a 2005–2010 retrospective cohort analysis
Authors: Meyssonnier Vanina , Bui Thuy Van , Veziris Nicolas , Jarlier Vincent , Robert Jérôme
Published: January 2014

Background

Rifampicin resistance is a risk factor for poor outcome in tuberculosis. Therefore, we sought to describe the characteristics and management of Rifampicin monoresistant (RMR) tuberculosis (TB) in France.

Methods

We conducted a retrospective cohort analysis in 2012 on RMR TB patients diagnosed in France between 2005 and 2010 by using a national laboratory network. A standardized questionnaire was used to collect basic demographic data, region of birth, history of TB, HIV-coinfection, alcohol use, and antituberculosis treatment. Outcome was assessed after at least 18 months of follow-up.

Results

A total of 39 patients with RMR TB were reported (0.12% of all TB cases). Overall, 19 (49%) had a previous history of treatment, 9 (23%) were HIV-coinfected, and 24 (62%) were smear-positive. Patient with secondary RMR were more likely to have alcohol abuse (P = 0.04) and HIV-coinfection (p = 0.04). Treatment outcome could be assessed for 30 patients, the nine others being dead or lost to follow-up. A total of 20 (67%) of the 30 assessed were cured, 3 (10%) died, 3 (10%) relapsed, and 4 (13%) were lost to follow up. Four (13%) received less than 6 months of treatment, 3 did not have any modification of the standardized regimen, 13 (43%) received fluoroquinolones, 4 (13%) aminoglycosides, and 8 (26%) a combination of both.

Conclusions

RMR TB is a rare disease in France, and its management was heterogeneous. The lack of treatment standardization may be a consequence of low expertise and may lead to the unsatisfactory low success rate.
The novel p.Cys65Tyr mutation in NR5A1gene in three 46,XY siblings with normal testosterone levels and their mother with primary ovarian insufficiency
Authors: Fabbri Helena Campos , de Andrade Juliana Gabriel Ribeiro , Soardi Fernanda Caroline , de Calais Flávia Leme , Petroli Reginaldo José , Maciel-Guerra Andréa Trevas , Guerra-Júnior Gil , de Mello Maricilda Palandi
Published: January 2014

Background

Disorders of sex development (DSD) is the term used for congenital conditions in which development of chromosomal, gonadal, or phenotypic sex is atypical. Nuclear receptor subfamily 5, group A, member 1 gene (NR5A1) encodes steroidogenic factor 1 (SF1), a transcription factor that is involved in gonadal development and regulates adrenal steroidogenesis. Mutations in the NR5A1 gene may lead to different 46,XX or 46,XY DSD phenotypes with or without adrenal failure. We report a Brazilian family with a novel NR5A1 mutation causing ambiguous genitalia in 46,XY affected individuals without Müllerian derivatives and apparently normal Leydig function after birth and at puberty, respectively. Their mother, who is also heterozygous for the mutation, presents evidence of primary ovarian insufficiency.

Case presentation

Three siblings with 46,XY DSD, ambiguous genitalia and normal testosterone production were included in the study. Molecular analyses for AR, SRD5A2 genes did not reveal any mutation. However, NR5A2 sequence analysis indicated that all three siblings were heterozygous for the p.Cys65Tyr mutation which was inherited from their mother. In silico analysis was carried out to elucidate the role of the amino acid change on the protein function. After the mutation was identified, all sibs and the mother had been reevaluated. Basal hormone concentrations were normal except that ACTH levels were slightly elevated. After 1 mcg ACTH stimulation test, only the older sib showed subnormal cortisol response.

Conclusion

The p.Cys65Tyr mutation located within the second zinc finger of DNA binding domain was considered deleterious upon analysis with predictive algorithms. The identification of heterozygous individuals with this novel mutation may bring additional knowledge on structural modifications that may influence NR5A1 DNA-binding ability, and may also contribute to genotype-phenotype correlations in DSD. The slightly elevated ACTH basal levels in all three patients with 46,XY DSD and the subnormal cortisol response after 1 mcg ACTH stimulation in the older sib indicate that a long-term follow-up for adrenal function is important for these patients. Our data reinforce that NR5A1 analysis must also be performed in 46,XY DSD patients with normal testosterone levels without AR mutations.
A European inventory of common electronic health record data elements for clinical trial feasibility
Authors: Doods Justin , Botteri Florence , Dugas Martin , Fritz Fleur
Published: January 2014

Background

Clinical studies are a necessity for new medications and therapies. Many studies, however, struggle to meet their recruitment numbers in time or have problems in meeting them at all. With increasing numbers of electronic health records (EHRs) in hospitals, huge databanks emerge that could be utilized to support research. The Innovative Medicine Initiative (IMI) funded project ‘Electronic Health Records for Clinical Research’ (EHR4CR) created a standardized and homogenous inventory of data elements to support research by utilizing EHRs. Our aim was to develop a Data Inventory that contains elements required for site feasibility analysis.

Methods

The Data Inventory was created in an iterative, consensus driven approach, by a group of up to 30 people consisting of pharmaceutical experts and informatics specialists. An initial list was subsequently expanded by data elements of simplified eligibility criteria from clinical trial protocols. Each element was manually reviewed by pharmaceutical experts and standard definitions were identified and added. To verify their availability, data exports of the source systems at eleven university hospitals throughout Europe were conducted and evaluated.

Results

The Data Inventory consists of 75 data elements that, on the one hand are frequently used in clinical studies, and on the other hand are available in European EHR systems. Rankings of data elements were created from the results of the data exports. In addition a sub-list was created with 21 data elements that were separated from the Data Inventory because of their low usage in routine documentation.

Conclusion

The data elements in the Data Inventory were identified with the knowledge of domain experts from pharmaceutical companies. Currently, not all information that is frequently used in site feasibility is documented in routine patient care.
VATS bullectomy and apical pleurectomy for spontaneous pneumothorax in a young patient with Swyer-James-Mc Leod syndrome: case report presentation and literature review focusing on surgically treated cases
Authors: Panagopoulos Nikolaos , Papavasileiou Gerasimos , Koletsis Efstratios , Kastanaki Myrto , Anastasiou Nikolaos
Published: January 2014

Background

Swyer-James-McLeod Syndrome (SJMS) is an uncommon, emphysematous disease characterized by radiologic hyperlucency of pulmonary parenchyma due to loss of the pulmonary vascular structure and to alveolar overdistension.

Case report

We herein describe a 15-year-old Caucasian patient with well-established SJMS since childhood who presented with spontaneous pneumothorax. Video-assisted thoracoscopic bullectomy with apical pleurectomy was performed. Since SJMS is considered an on-going inflammatory process, the patient one year after surgery exhibits excellent quality of life with no pneumothorax recurrence.
Growth arrest lines and intra-epiphyseal silhouettes: a case series
Authors: Kennedy Ian W , Irwin Greg J , Huntley James S
Published: January 2014

Background

Growth arrest lines can develop within the skeleton after physiological stress or trauma. They are usually evident on radiographs as transverse lines in the metaphyses and have been used in fields from palaeontology to orthopaedics. This report consists of three cases, two of which describe growth arrest lines in an intra-epiphyseal site hitherto rarely documented, and a third demonstrating their clinical application.

Case presentation

Case 1 describes a 9-year-old who suffered a knee hyperflexion injury requiring anterior cruciate ligament and posterior cruciate ligament reattachments. She subsequently developed a marked distal femoral intra-epiphyseal arrest silhouette, as well as metaphyseal arrest lines in the femur, tibia and fibula. Case 2 describes an 8-year-old who sustained a tibial spine fracture and underwent open reduction and internal fixation. Subsequent imaging shows a further example of femoral intra-epiphyseal arrest silhouette as well as tibia and fibula metaphyseal arrest lines. Case 3 describes a 10-year-old who sustained a distal tibia fracture which was managed with open reduction and internal fixation. Subsequently the metaphyseal growth arrest line was parallel to the physis, suggesting no growth arrest (a danger with such a fracture).

Conclusion

This case series describes two examples of rarely described intra-epiphyseal growth arrest silhouettes and demonstrates the usefulness of arrest lines when assessing for growth plate damage.
IL-17E (IL-25) and IL-17RB promote respiratory syncytial virus-induced pulmonary disease
Authors: Petersen Bryan C , Dolgachev Vladislav , Rasky Andrew , Lukacs Nicholas W
Published: January 2014

One of the most severe pathologic responses of RSV infection is associated with overproduction of cytokines and inflammation, leading to mucus hypersecretion. This study investigated the role of IL-25 in the development of RSV-associated immunopathology. IL-25 and its receptor IL-17RB were increased following RSV infection, and IL-25 blockade using neutralizing antibodies reduced RSV-associated pathology, AHR, and type 2 cytokine production. Likewise, IL-17RB−/− mice demonstrated a modified inflammatory response during RSV infection characterized by decreased Th2 and increased Th17 cytokine production. Additionally, the IL-17RB−/− mice demonstrated significantly reduced inflammation and cytokine production in a model of RSV-driven asthma exacerbation. These results indicate that IL-25 regulates the inflammatory response to RSV infection and that its inhibition may enable a reduction in the severity of RSV-associated pulmonary inflammation, including during viral-induced asthma exacerbation.
RETRACT: Anomalous phases in TE-mode magnetotellurics
Authors: Parker Robert L.
Published: January 2014

This paper has been retracted by the author on 10 March 2015. It was brought to the author’s attention that equation 3 of this paper has the incorrect sign. This error has the serious consequence that the anomalous phases for the system discussed in the paper are much smaller in amplitude than reported, and hence the main conclusion, that any phase may be found in TE mode induction, has not been demonstrated and is likely incorrect.
Progressive Collapse Analysis of Reinforced Concrete Frames with Unreinforced Masonry Infill Walls considering In-Plane/Out-of-Plane Interaction
Authors: Mosalam Khalid M. , Günay Selim
Published: January 2014

Reinforced concrete (RC) frames with unreinforced masonry (URM) infill walls are commonly used in seismic regions around the world. It is recognized that many buildings of this type perform poorly during earthquakes. Therefore, proper modeling of the infill walls and their effect on RC frames is essential to evaluate the seismic performance of such buildings and to select adequate retrofit methods. Using damage observations of RC buildings with URM infill walls from recent earthquakes, this paper presents a new approach to consider in-plane/out-of-plane interaction of URM infill walls in progressive collapse simulations. In addition, the infill wall effect to induce shear failure of columns is simulated with a nonlinear shear spring modeling approach. The research endeavor is accompanied by implementation of the developed modeling aspects in the publicly available open-source computational platform OpenSees for immediate access by structural engineers and researchers.
Nonparametric Estimation for a Class of Piecewise-Deterministic Markov Processes
Authors: Fujii Takayuki
Published: January 2014

In this paper we study nonparametric estimation problems for a class of piecewise-deterministic Markov processes (PDMPs). Borovkov and Last (2008) proved a version of Rice's formula for PDMPs, which explains the relation between the stationary density and the level crossing intensity. From a statistical point of view, their result suggests a methodology for estimating the stationary density from observations of a sample path of PDMPs. First, we introduce the local time related to the level crossings and construct the local-time estimator for the stationary density, which is unbiased and uniformly consistent. Secondly, we investigate other estimation problems for the jump intensity and the conditional jump size distribution.
ΕΠΙΔΡΑΣΗ ΤΟΥ ΚΑΤΑΓΜΑΤΟΣ ΤΟΥ ΜΗΡΙΑΙΟΥ ΟΣΤΟΥ ΣΤΗΝ ΚΑΤΑ ΜΗΚΟΣ ΑΝΑΠΤΥΞΗ ΤΟΥ ΟΣΤΟΥ ΑΥΤΟΥ ΚΑΙ ΤΗΣ ΣΥΣΤΟΙΧΗΣ ΚΝΗΜΗΣ ΣΤΟ ΣΚΥΛΟ
Authors: Στεφάνου Δημήτριος
Published: January 2014

ΣΚΟΠΟΣ ΤΗΣ ΠΕΙΡΑΜΑΤΙΚΗΣ ΑΥΤΗΣ ΕΡΓΑΣΙΑΣ ΕΙΝΑΙ Η ΜΕΛΕΤΗ ΤΗΣ ΕΠΙΔΡΑΣΗΣ ΤΟΥ ΤΕΛΕΙΟΥ 'Η ΤΟΥ ΑΤΕΛΟΥΣ ΚΑΤΑΓΜΑΤΟΣ ΤΟΥ ΜΗΡΙΑΙΟΥ ΟΣΤΟΥ, ΚΑΘΩΣ ΚΑΙ ΤΗΣ ΑΠΟΚΟΛΛΗΣΗΣ ΤΟΥ ΠΕΡΙΟΣΤΕΟΥ ΤΟΥ ΠΑΝΩ ΣΤΗΝ ΚΑΤΑ ΜΗΚΟΣ ΑΝΑΠΤΥΞΗ ΤΟΥ, ΚΑΘΩΣ ΚΑΙ ΣΤΗΝ ΑΝΑΠΤΥΞΗ ΤΗΣ ΣΥΣΤΟΙΧΗΣ ΚΝΗΜΗΣ ΣΤΟ ΣΚΥΛΟ. ΑΠΟ ΤΗ ΜΑΚΡΟΣΚΟΠΙΚΗ ΚΑΙ ΤΗΝ ΑΚΤΙΝΟΓΡΑΦΙΚΗ ΜΕΤΡΗΣΗ ΤΟΥ ΜΗΚΟΥΣ ΤΩΝ ΟΣΤΩΝ ΒΡΕΘΗΚΕ ΟΤΙ ΜΕΤΑ ΑΠΟ ΤΕΛΕΙΟ 'Η ΑΤΕΛΕΣ ΚΑΤΑΓΜΑ ΥΠΗΡΞΕ ΕΠΙΜΗΚΥΝΣΗ ΤΩΝ ΣΠΑΣΜΕΝΩΝ ΟΣΤΩΝ ΚΑΘΩΣ ΚΑΙ ΤΩΝ ΣΥΣΤΟΙΧΩΝ ΚΝΗΜΩΝ ΣΕ ΣΧΕΣΗ ΠΡΟΣ ΤΑ ΑΝΤΙΣΤΟΙΧΑ ΥΓΙΗ ΟΣΤΑ. ΑΝΤΙΘΕΤΑ, ΜΕΤΑ ΑΠΟ ΑΠΟΚOΛΛΗΣΗ ΤΟΥ ΠΕΡΙΟΣΤΕΟΥ ΔΕ ΔΙΑΠΙΣΤΩΘΗΚΕ ΣΤΑΤΙΣΤΙΚΩΣ ΣΗΜΑΝΤΙΚΗ ΔΙΑΦΟΡΑ ΣΤΟ ΜΗΚΟΣ ΤΩΝ ΕΞΕΤΑΖΟΜΕΝΩΝ ΟΣΤΩΝ. ΙΣΤΟΛΟΓΙΚΑ ΔΙΑΠΙΣΤΩΘΗΚΕ ΟΤΙ Ο ΣΥΖΕΥΚΤΙΚΟΣ ΧΟΝΔΡΟΣ ΤΟΥ ΚΑΤΩ ΑΚΡΟΥ ΤΟΥ ΜΗΡΙΑΙΟΥ ΟΣΤΟΥ ΤΩΝ ΣΚΥΛΩΝ ΜΕ ΚΑΤΑΓΜΑ ΤΕΛΕΙΟ 'Η ΑΤΕΛΕΣ ΗΤΑΝ ΔΙΕΥΡΥΣΜΕΝΟΣ ΣΕ ΣΧΕΣΗ ΠΡΟΣ ΤΟΝ ΑΝΤΙΣΤΟΙΧΟ ΤΟΥ ΥΓΙΟΥΣ ΟΣΤΟΥ. ΑΝΑΛΟΓΗ ΔΙΕΥΡΥΝΣΗ ΔΙΑΠΙΣΤΩΘΗΚΕ ΚΑΙ ΣΤΟ ΣΥΖΕΥΚΤΙΚΟ ΧΟΝΔΡΟ ΤΟΥ ΑΝΩ ΑΚΡΟΥ ΤΗΣ ΣΥΣΤΟΙΧΗΣ ΚΝΗΜΗΣ. ΤΕΛΟΣ, ΥΣΤΕΡΑ ΑΠΟ ΤΕΛΕΙΟ ΚΑΤΑΓΜΑ ΤΟΥ ΜΗΡΙΑΙΟΥ ΟΣΤΟΥ ΔΙΑΠΙΣΤΩΘΗΚΕ ΑΥΞΗΣΗ ΤΗΣ ΑΙΜΑΤΩΣΗΣ ΤΟΥ ΣΥΖΕΥΚΤΙΚΟΥ ΧΟΝΔΡΟΥ ΤΟΥ ΟΣΤΟΥΑΥΤΟΥ, ΚΑΘΩΣ ΕΠΙΣΗΣ ΚΑΙ ΤΗΣ ΣΥΣΤΟΙΧΗΣ ΚΝΗΜΗΣ.
ΣΥΜΒΟΛΗ ΣΤΗΝ ΜΕΛΕΤΗ ΚΑΙ ΘΕΡΑΠΕΥΤΙΚΗ ΑΝΤΙΜΕΤΩΠΙΣΗ ΤΗΣ ΚΑΥΣΑΛΓΙΑΣ ΤΟΥ ΣΤΟΜΑΤΟΣ
Authors: Λίνκ-Τσατσούλη Ίρις
Published: January 2014

ΜΕ ΤΟΝ ΟΡΟ ΚΑΥΣΑΛΓΙΑ ΤΟΥ ΣΤΟΜΑΤΙΚΟΥ ΒΛΕΝΝΟΓΟΝΟΥ ΟΡΙΖΕΤΑΙ Η ΔΥΣΑΙΣΘΗΣΙΑ ΠΟΥ ΕΚΔΗΛΩΝΕΤΑΙ ΣΤΟΝ ΒΛΕΝΝΟΓΟΝΟ ΤΟΥ ΣΤΟΜΑΤΟΣ ΜΕ ΑΙΣΘΗΜΑ ΚΑΥΣΟΥ. ΘΕΩΡΕΙΤΑΙ ΩΣ ΠΟΛΥΑΙΤΙΟΛΟΓΙΚΟ ΣΥΜΠΤΩΜΑ ΚΑΙ Ο ΑΙΤΙΟΠΑΘΟΓΕΝΕΤΙΚΟΣ ΜΗΧΑΝΙΣΜΟΣ ΕΙΝΑΙ ΑΓΝΩΣΤΟΣ. ΣΤΗΝ ΕΡΓΑΣΙΑ ΕΓΙΝΕ ΠΡΟΣΠΑΘΕΙΑ ΝΑ ΜΕΛΕΤΗΘΕΙ ΤΟ ΣΥΜΠΤΩΜΑ ΑΠΟ ΑΙΤΙΟΠΑΘΟΓΕΝΕΤΙΚΗΣ ΠΛΕΥΡΑΣ.ΓΙΑ ΤΟΝ ΛΟΓΟ ΑΥΤΟ ΕΓΙΝΕ Η ΑΝΑΛΥΣΗ ΚΑΙ ΣΥΣΧΕΤΙΣΗ ΤΩΝ ΠΑΡΑΓΟΝΤΩΝ ΠΟΥ ΣΥΝΘΕΤΟΥΝΤΑ ΙΣΤΟΡΙΚΑ ΤΩΝ ΑΣΘΕΝΩΝ ΚΑΙ Η ΑΞΙΟΛΟΓΗΣΗ ΤΩΝ ΔΙΑΦΟΡΩΝ ΘΕΡΑΠΕΥΤΙΚΩΝ ΣΧΗΜΑΤΩΝ ΠΟΥ ΕΦΑΡΜΟΣΘΗΚΑΝ. ΤΟ ΥΛΙΚΟ ΤΗΣ ΕΡΓΑΣΙΑΣ ΑΠΕΤΕΛΕΣΑΝ 72 ΑΣΘΕΝΕΙΣ (20 ΑΝΤΡΕΣ, 52 ΓΥΝΑΙΚΕΣ) ΗΛΙΚΙΑΣ ΑΠΟ 35-78 ΕΤΩΝ, ΠΟΥ ΜΕΤΑ ΑΠΟ ΛΕΠΤΟΜΕΡΗ ΚΛΙΝΙΚΟΕΡΓΑΣΤΗΡΙΑΚΟ ΕΛΕΓΧΟ ΧΩΡΙΣΤΗΚΑΝ ΣΕ ΑΣΘΕΝΕΙΣ ΠΟΥ ΠΑΡΟΥΣΙΑΖΟΥΝ: 1. ΣΙΔΗΡΟΠΕΝΙΑ, 2. ΣΑΚΧΑΡΩΔΗ ΔΙΑΒΗΤΗ, 3. ΙΔΙΟΠΑΘΗ ΚΑΥΣΑΛΓΙΑ ΤΟΥ ΣΤΟΜΑΤΟΣ. ΤΑ ΘΕΡΑΠΕΥΤΙΚΑ ΣΧΗΜΑΤΑ ΠΟΥ ΑΚΟΛΟΥΘΗΘΗΚΑΝ ΗΤΑΝ ΑΙΤΙΟΛΟΓΙΚΑ ΣΤΗΝ 1Η ΚΑΙ 2Η ΟΜΑΔΑ. Η ΣΥΜΠΤΩΜΑΤΙΚΗ ΘΕΡΑΠΕΥΤΙΚΗ ΑΝΤΙΜΕΤΩΠΙΣΗ ΕΦΑΡΜΟΣΘΗΚΕ ΣΤΗΝ 3Η ΟΜΑΔΑ ΜΕ ΤΗΝ ΧΟΡΗΓΗΣΗ ΒΙΤΑΜΙΝΩΝ ΤΟΥ ΣΥΜΠΛΕΓΜΑΤΟΣ Β'Η ΤΟΥ ΑΠΟΚΛΕΙΣΜΟΥ ΤΟΥ ΑΣΤΕΡΟΕΙΔΟΥΣ ΓΑΓΓΛΙΟΥ. ΤΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΚΑΙ ΣΥΜΠΕΡΑΣΜΑΤΑ ΠΟΥ ΠΡΟΕΚΥΨΑΝ ΕΙΝΑΙ ΟΤΙ Η ΚΑΥΣΑΛΓΙΑ ΤΟΥ ΣΤΟΜΑΤΟΣ: - ΕΚΔΗΛΩΝΕΤΑΙ ΣΥΧΝΟΤΕΡΑ ΣΕ ΓΥΝΑΙΚΕΣ ΜΕΤΑ ΤΗΝ ΜΕΣΗ ΗΛΙΚΙΑ, - ΕΝΤΟΠΙΖΕΤΑΙ ΚΥΡΙΩΣ ΣΤΟ ΠΡΟΣΘΙΟ ΜΕΡΟΣ ΤΟΥ ΣΤΟΜΑΤΟΣ, - ΠΑΡΟΥΣΙΑΖΕΙ ΜΑΚΡΟΧΡΟΝΙΑ ΠΟΡΕΙΑ, - ΠΑΡΟΥΣΙΑΖΕΤΑΙ ΣΥΧΝΟΤΕΡΑ ΣΕ ΑΤΟΜΑ ΜΕ ΝΕΥΡΟΦΥΤΙΚΕΣ ΔΙΑΤΑΡΑΧΕΣ ΟΙ ΟΠΟΙΕΣ ΕΠΗΡΕΑΖΟΥΝ ΑΡΝΗΤΙΚΑ ΤΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΤΩΝ ΘΕΡΑΠΕΥΤΙΚΩΝ ΠΡΟΣΠΑΘΕΙΩΝ ΚΑΙ ΕΠΙΣΗΣ ΣΕ ΜΕΓΑΛΟ ΠΟΣΟΣΤΟ ΣΕ ΑΤΟΜΑ ΠΟΥ ΛΑΜΒΑΝΟΥΝ ΗΡΕΜΙΣΤΙΚΑ ΦΑΡΜΑΚΑ, - ΕΠΗΡΕΑΖΕΤΑΙ ΩΣ ΠΡΟΣ ΤΗΝ ΕΚΒΑΣΗ ΤΗΣ ΘΕΡΑΠΕΥΤΙΚΗΣ ΑΝΤΙΜΕΤΩΠΙΣΗΣ ΤΗΣ ΑΡΝΗΤΙΚΑ ΑΠΟ ΤΗΝ ΠΡΟΧΩΡΗΜΕΝΗ ΗΛΙΚΙΑ ΤΟΥ ΑΣΘΕΝΗ ΚΑΙ ΑΠΟ ΤΟ ΜΕΓΑΛΟ ΧΡΟΝΙΚΟ ΔΙΑΣΤΗΜΑ ΥΠΑΡΞΗΣ ΤΗΣ, - ΠΡΟΚΑΛΕΙΤΑΙ ΣΕ ΣΗΜΑΝΤΙΚΟ ΠΟΣΟΣΤΟ ΑΠΟ ΣΙΔΗΡΟΠΕΝΙΑ,- ΣΑΝ ΙΔΙΟΠΑΘΗΣ ΜΟΡΦΗ ΔΕΝ ΑΝΤΙΜΕΤΩΠΙΖΕΤΑΙ ΙΚΑΝΟΠΟΙΗΤΙΚΑ ΜΕ ΤΗΝ ΧΟΡΗΓΗΣΗ ΒΙΤΑΜΙΝΩΝ ΤΟΥ ΣΥΜΠΛΕΓΜΑΤΟΣ Β. Η ΙΔΙΟΠΑΘΗΣ ΜΟΡΦΗ ΑΝΤΙΜΕΤΩΠΙΖΕΤΑΙ ΙΚΑΝΟΠΟΙΗΤΙΚΑ ΔΙΑΓΝΩΣΤΙΚΑ ΚΑΙ ΘΕΡΑΠΕΥΤΙΚΑ ΜΕ ΤΗΝ ΜΕΘΟΔΟ ΤΟΥ ΑΠΟΚΛΕΙΣΜΟΥ ΤΟΥ ΑΣΤΕΡΟΕΙΔΟΥΣ ΓΑΓΓΛΙΟΥ ΓΕΓΟΝΟΣ ΠΟΥ ΕΠΙΒΕΒΑΙΩΘΗΚΕ ΜΕ ΤΙΣ ΠΑΡΑΤΗΡΗΣΕΙΣ ΠΟΥ ΕΓΙΝΑΝ ΚΑΤΑ ΤΗΝ ΔΙΑΡΚΕΙΑ 1 ΕΤΟΥΣ ΣΕ 10 ΑΣΘΕΝΕΙΣ.
ΕΞΑΓΩΓΗ ΣΥΝΑΡΤΗΣΕΩΝ ΔΟΜΗΣ GLUONS ΤΟΥ ΠΙΟΝΙΟΥ ΚΑΙ ΑΝΤΙΠΡΩΤΟΝΙΟΥ ΑΠΟ ΜΕΛΕΤΗ ΠΑΡΑΓΩΓΗΣ Ψ
Authors: Τζαμαρίας Σπύρος
Published: January 2014

ΣΥΓΚΡΙΝΟΝΤΑΣ ΤΗΝ ΘΕΩΡΗΤΙΚΗ ΠΡΟΒΛΕΨΗ ΤΗΣ XF ΚΑΤΑΝΟΜΗΣ ΤΟΥ Ψ ΑΠΟ ΑΔΡΟΝΙΚΕΣ ΑΝΤΙΔΡΑΣΕΙΣ ΜΕ ΤΗΝ ΙΔΙΑ ΚΑΤΑΝΟΜΗ ΠΟΥ ΜΕΤΡΗΣΕ ΤΟ ΠΕΙΡΑΜΑ ES37 ΤΟΥ FERMILAB, ΠΡΟΣΔΙΟΡΙΣΘΗΚΑΝ ΟΙ ΣΥΝΑΡΤΗΣΕΙΣ ΔΟΜΗΣ ΤΩΝ GLUONS. ΣΤΗΝ ΣΥΓΚΡΙΣΗ ΠΑΙΡΝΟΝΤΑΙ ΥΠ'ΟΨΗ ΟΛΟΙ ΟΙ ΠΑΡΑΓΟΝΤΕΣ ΠΟΥ ΕΠΗΡΕΑΖΟΥΝ ΤΟ ΣΧΗΜΑ ΤΗΣ XF ΚΑΤΑΝΟΜΗΣ.
Η ΜΕΛΕΤΗ ΤΩΝ ΙΧΝΟΣΤΟΙΧΕΙΩΝ ZN ΚΑΙ CU ΣΕ ΚΑΡΚΙΝΟ ΤΟΥ ΛΑΡΥΓΓΑ
Authors: Σέγγας Ιωάννης
Published: January 2014

ΣΕ 30 ΑΤΟΜΑ ΠΟΥ ΕΠΑΣΧΑΝ ΑΠΟ ΚΑΡΚΙΝΟ ΤΟΥ ΛΑΡΥΓΓΑ, ΜΕΛΕΤΗΘΗΚΑΝ ΟΙ ΔΙΑΚΥΜΑΝΣΕΙΣ ΤΩΝ ΠΥΚΝΟΤΗΤΩΝ ΤΟΥ ΨΕΥΔΑΡΓΥΡΟΥ ΚΑΙ ΧΑΛΚΟΥ ΣΤΟ ΟΡΟ ΚΑΙ ΣΤΟΝ ΥΓΙΗ ΚΑΙ ΚΑΡΚΙΝΙΚΟ ΛΑΡΥΓΓΙΚΟ ΙΣΤΟ. ΤΡΙΑΝΤΑ ΑΛΛΑ ΑΤΟΜΑ ΧΡΗΣΙΜΕΥΣΑΝ ΣΑΝ ΜΑΡΤΥΡΕΣ. Η ΣΥΓΚΕΝΤΡΩΣΗ ΤΟΥ ΨΕΥΔΑΡΓΥΡΟΥ ΕΙΝΑΙ ΣΗΜΑΝΤΙΚΑ ΕΛΑΤΤΩΜΕΝΗΣ ΣΤΟΝ ΟΡΟ ΚΑΙ ΑΥΞΗΜΕΝΗ ΣΤΟΝ ΚΑΡΚΙΝΙΚΟ ΙΣΤΟ ΤΟΥ ΚΑΡΚΙΝΟΠΑΘΟΥΣ ΣΕ ΣΧΕΣΗ ΜΕ ΤΟΝ ΥΓΙΗ ΛΑΡΥΓΓΙΚΟ ΙΣΤΟ. Η ΣΥΓΚΕΝΤΡΩΣΗ ΤΟΥ ΧΑΛΚΟΥ ΕΙΝΑΙ ΣΗΜΑΝΤΙΚΑ ΑΥΞΗΜΕΝΗ ΚΑΙ ΣΤΟΝ ΟΡΟ ΚΑΙ ΣΤΟΝ ΚΑΡΚΙΝΙΚΟ ΛΑΡΥΓΓΙΚΟ ΙΣΤΟ.ΕΝΔΕΧΕΤΑΙ Ο ΚΑΘΟΡΙΣΜΟΣ ΤΩΝ ΠΙΟ ΠΑΝΩ ΙΧΝΟΣΤΟΙΧΕΙΩΝ ΣΤΟΝ ΚΑΡΚΙΝΟ ΤΟΥ ΛΑΡΥΓΓΑ ΝΑΠΑΙΖΕΙ ΡΟΛΟ ΣΤΗΝ ΠΡΟΓΝΩΣΗ, ΕΓΚΑΙΡΗ ΔΙΑΓΝΩΣΗ ΔΙΑΦΟΡΟΔΙΑΓΝΩΣΗ ΚΑΙ ΕΚΤΙΜΗΣΗ ΔΙΑΦΟΡΩΝ ΘΕΡΑΠΕΥΤΙΚΩΝ ΣΧΗΜΑΤΩΝ.
ΔΙΑΛΕΙΠΟΥΣΑ ΧΩΛΟΤΗΣ ΤΗΣ ΙΠΠΟΥΡΙΔΟΣ
Authors: Χριστοδουλίδης Αντώνιος
Published: January 2014

Η ΔΙΑΛΕΙΠΟΥΣΑ ΧΩΛΟΤΗΣ ΤΗΣ ΙΠΠΟΥΡΙΔΟΣ ΠΡΟΚΑΛΕΙΤΑΙ ΛΟΓΩ ΠΙΕΣΕΩΣ ΤΗΣ ΙΠΠΟΥΡΙΔΟΣ 'Η ΤΩΝ ΡΙΖΩΝ ΤΗΣ ΕΝΤΟΣ ΕΝΟΣ ΕΣΤΕΝΩΜΕΝΟΥ ΟΣΦΥΙΚΟΥ ΣΠΟΝΔΥΛΙΚΟΥ ΣΩΛΗΝΟΣ. ΧΑΡΑΚΤΗΡΙΖΕΤΑΙ ΥΠΟ ΑΙΣΘΗΤΙΚΩΝ ΚΥΡΙΩΣ ΣΩΜΑΤΩΝ ΣΧΕΤΙΖΟΜΕΝΩΝ ΠΡΟΣ ΑΣΚΗΣΙΝ ΤΩΝ ΚΑΤΩ ΑΚΡΩΝ 'Η ΠΡΟΣ ΟΡΙΣΜΕΝΑΣ ΘΕΣΕΙΣ ΤΟΥ ΣΩΜΑΤΟΣ. ΑΛΓΟΣ ΠΑΡΑΤΗΡΕΙΤΑΙ ΣΥΝΗΘΩΣ ΕΙΣ ΠΕΡΙΠΤΩΣΕΙΣ ΠΛΑΓΙΑΣ ΚΗΛΗΣ ΟΣΦΥΙΚΟΥ ΜΕΣΟΣΠΟΝΔΥΛΙΟΥ ΔΙΣΚΟΥ ΚΑΙ ΕΙΣ ΕΤΕΡΑΣ ΠΕΡΙΠΤΩΣΕΙΣ ΕΑΝ ΥΦΙΣΤΑΤΑΙ ΕΧΕΙ ΠΑΡΑΙΣΘΗΤΙΚΗΝ ΠΟΙΟΤΗΤΑ. ΥΦΙΣΤΑΝΤΑΙ ΔΥΟ ΘΕΩΡΙΑΙ ΔΙΑ ΤΟΝ ΜΗΧΑΝΙΣΜΟΝ ΠΡΟΚΛΗΣΕΩΣ ΤΩΝ ΣΥΜΠΤΩΜΑΤΩΝ: Η ΜΗΧΑΝΙΚΗ ΗΤΙΣ ΑΠΟΔΙΔΕΙ ΤΗΝ ΕΜΦΑΝΙΣΙΝ ΤΩΝ ΣΥΜΠΤΩΜΑΤΩΝ ΕΙΣ ΕΚΤΑΣΙΝ ΤΗΣ ΟΣΦΥΙΚΗΣ ΜΟΙΡΑΣ ΤΗΣ ΣΠΟΝΔΥΛΙΚΗΣ ΣΤΗΛΗΣ ΚΑΙ Η ΑΓΓΕΙΑΚΗΗΤΙΣ ΑΠΟΔΙΔΕΙ ΤΑ ΣΥΜΠΤΩΜΑΤΑ ΕΙΣ ΑΡΤΗΡΙΑΚΗΝ ΑΝΕΠΑΡΚΕΙΑΝ ΤΩΝ ΡΙΖΩΝ ΤΗΣ ΙΠΠΟΥΡΙΔΟΣ. Η ΕΞΕΤΑΣΙΣ ΤΩΝ ΑΣΘΕΝΩΝ ΕΝ ΗΡΕΜΙΑ ΕΛΑΧΙΣΤΗΣ ΝΕΥΡΟΛΟΓΙΚΑΣ ΑΝΩΜΑΛΙΑΣ ΑΠΟΚΑΛΥΠΤΕΙ ΟΜΩΣ ΔΥΝΑΤΟΝ ΝΑ ΚΑΤΑΣΤΟΥΝ ΕΜΦΑΝΕΙΣ ΜΕΤΑ ΑΣΚΗΣΙΝ ΤΩΝ ΚΑΤΩ ΑΚΡΩΝ. Η ΘΕΡΑΠΕΙΑΕΙΝΑΙ ΜΟΝΟΝ ΧΕΙΡΟΥΡΓΙΚΗ ΚΑΙ ΣΥΝΙΣΤΑΤΑΙ ΕΙΣ ΑΦΑΙΡΕΣΙΝ ΤΗΣ ΚΗΛΗΣ ΤΟΥ ΔΙΣΚΟΥ ΕΙΣΠΕΡΙΠΤΩΣΕΙΣ "ΑΠΛΗΣ" ΚΗΛΗΣ ΔΙΣΚΟΥ ΚΑΙ ΕΙΣ ΕΥΡΕΙΑΝ ΠΕΤΑΛΕΚΤΟΜΗΝ ΕΙΣ ΠΕΡΙΠΤΩΣΕΙΣ ΓΕΝΙΚΕΥΜΕΝΗΣ ΣΤΕΝΩΣΕΩΣ ΤΟΥ ΟΣΦΥΙΚΟΥ ΣΠΟΝΔΥΛΙΚΟΥ ΣΩΛΗΝΟΣ.
ΑΝΤΙ ΜΗΝΙΓΓΙΤΙΔΟΚΟΚΚΙΚΑ ΑΝΤΙΣΩΜΑΤΑ ΣΕ ΠΑΙΔΙΑ ΚΑΙ ΕΝΗΛΙΚΟΥΣ
Authors: Μανωλάκη Αρχοντία
Published: January 2014

1) ΠΡΟΣΔΙΟΡΙΣΤΗΚΑΝ ΜΕ ΤΗ ΜΕΘΟΔΟ ΤΗΣ ΠΑΘΗΤΙΚΗΣ ΑΙΜΟΣΥΓΚΟΛΛΗΣΗΣ ΑΝΤΙΜΗΝΙΓΓΙΤΙΔΟΚΟΚΚΙΚΑ ΑΝΤΙΣΩΜΑΤΑ ΣΕ 949 ΔΕΙΓΜΑΤΑ ΟΡΟΥ ΑΠΟ Α) 222 ΠΑΙΔΙΑ ΠΟΥ ΝΟΣΗΛΕΥΟΝΤΑΝ ΓΙΑ ΜΗΝΙΓΓΙΤΙΔΑ, Β) 69 ΥΓΙΗ ΑΔΕΛΦΙΑ ΚΑΙ 301 ΓΟΝΕΙΣ ΤΩΝ ΠΑΙΔΙΩΝ ΑΥΤΩΝ. Γ) 41 ΠΑΙΔΙΑΠΟΥ ΝΟΣΗΛΕΥΟΤΑΝ ΓΙΑ ΑΛΛΟ ΝΟΣΗΜΑ, ΚΑΙ Δ) 217 ΥΓΙΕΙΣ ΕΝΗΛΙΚΟΥΣ (ΥΓΕΙΟΝΟΜΙΚΟ ΠΡΟΣΩΠΙΚΟ, ΑΙΜΟΔΟΤΕΣ, ΓΟΝΕΙΣ ΠΟΥ ΣΥΝΟΔΕΥΑΝ ΠΑΙΔΙΑ ΤΟΥΣ ΕΞΩΤΕΡΙΚΑ ΙΑΤΡΕΙΑ ΤΟΥ ΝΟΣΟΚΟΜΕΙΟΥ). 2) Ο ΕΠΙΠΟΛΑΣΜΟΣ ΑΝΤΙ-Β ΑΝΤΙΣΩΜΑΤΩΝ ΚΥΜΑΝΘΗΚΕ ΣΤΙΣ ΔΙΑΦΟΡΕΣ ΟΜΑΔΕΣ ΕΝΗΛΙΚΩΝ ΜΕΤΑΞΥ 53% ΚΑΙ 71,4% ΜΕ ΜΟΝΗ ΕΞΑΙΡΕΣΗ ΤΗΝ ΟΜΑΔΑ (Ν 116) ΤΩΝ ΥΓΕΙΟΝΟΜΙΚΩΝ ΟΠΟΥ Ο ΕΠΙΠΟΛΑΣΜΟΣ ΒΡΕΘΗΚΕ ΑΝΕΞΗΓΗΤΑ ΧΑΜΗΛΟΣ (21,5%). 3) ΔΕΝ ΠΑΡΑΤΗΡΗΘΗΚΑΝ ΔΙΑΦΟΡΕΣ ΜΕΤΑΞΥ ΑΝΔΡΩΝ ΚΑΙ ΓΥΝΑΙΚΩΝ (Ρ > 0,1) ΕΚΤΟΣ ΑΠΟ ΤΟΥΣ ΓΟΝΕΙΣ ΠΑΙΔΙΩΝ ΜΕ ΜΗΝΙΓΓΙΤΙΔΑ ΑΓΝΩΣΤΗΣ ΑΙΤΙΟΛΟΓΙΑΣ ΠΟΥ ΟΙ ΜΗΤΕΡΕΣ ΕΙΧΑΝ ΣΕ ΜΕΓΑΛΥΤΕΡΟ ΠΟΣΟΣΤΟ ΑΝΤΙΣΩΜΑΤΑ ΑΠΟ ΤΟΥΣ ΠΑΤΕΡΕΣ (Ρ < 0,001). (ΠΕΡΙΚΟΠΗ)
ΑΥΤΟΜΑΤΟΣ ΔΙΑΤΗΡΗΣΙΣ ΤΗΣ ΑΡΤΗΡΙΑΚΗΣ ΠΙΕΣΕΩΣ ΔΙ' ΕΛΕΓΧΟΜΕΝΗΣ ΑΡΤΗΡΙΑΚΗΣ ΑΦΑΙΜΑΞΕΩΣ ΕΝΤΟΣ ΚΛΕΙΣΤΟΥ ΑΣΚΟΥ ΜΕΓΑΛΗΣ ΕΝΔΟΤΙΚΟΤΗΤΟΣ
Authors: Κοντογιάννης Δημήτριος
Published: January 2014

ΣΚΟΠΟΣ Η ΡΥΘΜΙΣΗ ΤΗΣ ΥΨΗΛΗΣ ΑΡΤΗΡΙΑΚΗΣ ΠΙΕΣΕΩΣ ΠΕΡΙ ΠΡΟΚΑΘΩΡΙΣΜΕΝΟΥ ΕΠΙΠΕΔΟΥ ΣΤΟΧΟΥ. ΕΓΙΝΑΝ ΠΕΙΡΑΜΑΤΑ IN VITRO ΚΑΙ IN VIVO. ΕΙΣ ΤΑ IN VITRO ΠΕΙΡΑΜΑΤΑ ΚΑΤΕΣΚΕΥΑΣΘΗ ΣΥΣΚΕΥΗ ΕΙΣ 12 ΚΟΙΝΩΝ ΑΣΚΩΝ ΤΟΥ ΕΜΠΟΡΙΟΥ ΕΦΗΡΜΟΣΜΕΝΩΝ ΜΕ ΜΕΓΙΣΤΗΝ ΠΙΕΣΗ ΠΛΗΡΩΣΕΩΣ 126 MM HG, ΜΕΓΙΣΤΗ ΠΙΕΣΗ ΕΚΚΕΝΩΣΕΩΣ 119,4 MMHG ΚΑΙ ΥΨΙΠΕΔΟΥ ΠΙΕΣΕΩΣ 94 MM HG. ΤΟ ΥΨΙΠΕΔΟΝ ΑΥΤΟ ΗΤΟ ΚΑΙ ΤΟ ΕΠΙΠΕΔΟΝ ΣΤΟΧΟΣΔΙΑ ΤΗΝ ΡΥΘΜΙΣΗ ΤΗΣ ΑΡΤΗΡΙΑΚΗΣ ΠΙΕΣΕΩΣ ΤΩΝ ΠΕΙΡΑΜΑΤΟΖΩΩΝ. ΕΙΣ ΤΑ IN VIVO ΠΕΙΡΑΜΑΤΑ Η ΕΦΑΡΜΟΓΗ ΤΗΣ ΣΥΣΚΕΥΗΣ ΕΡΥΘΜΙΣΕ ΤΗΝ ΑΡΤΗΡΙΑΚΗ ΠΙΕΣΗ ΤΩΝ ΚΥΝΩΝ ΕΙΣ ΤΟ ΕΠΙΠΕΔΟΝ ΤΩΝ 106,90 +- 8,81 MM HG ΕΝΩ Η ΑΡΧΙΚΗ ΠΙΕΣΗ ΗΤΑΝ 184,20 +- 43,33 MM HG (Χ +- SD) ΕΝΤΟΣ 5 ΜΙΝ ΕΙΧΕ ΕΠΙΤΕΥΧΘΕΙ ΤΟ 88,1 +- 19,3% ΤΗΣ ΣΥΝΟΛΙΚΗΣ ΔΙΟΡΘΩΣΕΩΣ ΤΗΣ ΑΡΤΗΡΙΑΚΗΣ ΠΙΕΣΕΩΣ. ΣΥΜΠΕΡΑΣΜΑ: Η ΠΡΟΣΑΡΤΗΣΗ ΤΗΣ ΣΥΣΚΕΥΗΣ ΕΙΣ ΤΟ ΑΡΤΗΡΙΑΚΟ ΣΥΣΤΗΜΑ ΤΩΝ ΚΥΝΩΝ ΕΡΥΘΜΙΣΕ ΤΗΝ ΑΡΤΗΡΙΑΚΗ ΠΙΕΣΗ ΣΤΟ ΕΠΙΠΕΔΟ ΣΤΟΧΟ ΚΑΙ ΜΑΛΙΣΤΑ ΤΑΧΕΩΣ ΚΑΙ ΧΩΡΙΣ ΔΙΑΚΥΜΑΝΣΕΙΣ. ΤΟ ΠΡΟΒΛΗΜΑ ΠΗΞΙΣ-ΘΡΟΜΒΩΣΙΣ ΔΕΝ ΕΠΙΤΡΕΠΕΙ ΧΡΟΝΙΑΝ ΕΦΑΡΜΟΓΗΝ.
ΦΛΕΒΟΘΡΟΜΒΩΣΙΣ ΚΑΙ ΠΡΟΛΗΨΙΣ ΑΥΤΗΣ ΔΙΑ ΣΟΥΛΦΙΝΠΥΡΑΖΟΝΗΣ ΕΠΙ ΥΠΕΡΗΒΙΚΗΣ ΠΡΟΣΤΑΤΕΚΤΟΜΗΣ
Authors: Τροβάς Αλέξανδρος
Published: January 2014

ΕΜΕΛΕΤΗΘΗΣΑΝ 84 ΑΣΘΕΝΕΙΣ ΟΙ ΟΠΟΙΟΙ ΥΠΟΒΛΗΘΗΣΑΝ ΣΕ ΥΠΕΡΗΒΙΚΗ ΠΡΟΣΤΑΤΕΚΤΟΜΗ ΚΑΙ ΕΧΟΡΗΓΗΘΗ ΕΙΣ ΤΟΥΣ 42 1G SULTIN PYRAZONE ΚΑΙ ΕΙΣ ΤΟΥΣ ΑΛΛΟΥΣ 42 ΑΔΡΑΝΗΣ ΟΥΣΙΑ PLACEB. Η ΕΡΓΑΣΙΑ ΕΓΕΝΕΤΟ ΔΙΑ ΔΙΠΛΗΣ ΤΥΦΛΗΣ ΔΟΚΙΜΑΣΙΑΣ. ΔΙΑΠΙΣΤΩΘΗΚΑΝ ΤΑ ΕΞΗΣ:1) ΕΙΣ ΤΗΝ ΟΜΑΔΑ Α (ΜΑΡΤΥΡΕΣ ΦΛΕΒΟΘΡΟΜΒΩΣΙΣ ΠΑΡΕΤΗΡΗΘΗ ΚΛΙΝΙΚΩΣ ΕΙΣ 4 ΑΤΟΜΑ, ΠΟΣΟΣΤΟ 9,5% ΕΝΩ ΔΙΑ ΤΗΣ ΡΑΔΙΟΙΣΟΤΟΠΙΚΗΣ ΜΕΘΟΔΟΥ ΕΙΣ 14 (ΠΟΣΟΣΤΟ 33,3%). 2) ΕΚΤΩΝ ΑΣΘΕΝΩΝ ΤΗΣ ΟΜΑΔΟΣ Β ΚΛΙΝΙΚΗ ΦΛΕΒΟΘΡΟΜΒΩΣΙΣ ΔΙΑΓΝΩΣΘΗ ΕΙΣ 2 ΑΤΟΜΑ, ΗΤΟΙ ΠΟΣΟΣΤΟ 4,8% ΕΝΩ ΔΙΑ ΤΗΣ ΡΑΔΙΟΙΣΟΤΟΠΙΚΗΣ ΜΕΘΟΔΟΥ ΕΙΣ 7 ΑΤΟΜΑ ΗΤΟΙ ΠΟΣΟΣΤΟ 16,7%. 3) Η ΣΤΑΤΙΣΤΙΚΗ ΑΝΑΛΥΣΙΣ ΤΗΣ ΣΥΧΝΟΤΗΤΟΣ ΤΗΣ ΦΛΕΒΟΘΡΟΜΒΩΣΕΩΣ ΜΕΤΑΞΥ ΤΩΝ 2 ΟΜΑΔΩΝ ΕΔΕΙΞΑΝ ΟΤΙ Η ΟΜΑΣ Β ΕΝΕΦΑΝΙΣΑΝ ΜΙΚΡΟΤΕΡΑ ΣΥΧΝΟΤΗΤΑ ΤΩΝ ΜΑΡΤΥΡΩΝ, ΣΤΑΤΙΣΤΙΚΩΣ ΣΗΜΑΝΤΙΚΗ (Ρ < 0,02).
ΜΗΧΑΝΙΣΜΟΣ HIGGS ΓΙΑ ΑΒΕΛΙΑΝΕΣ ΘΕΩΡΙΕΣ ΒΑΘΜΙΔΑΣ ΣΕ ΧΩΡΟΧΡΟΝΙΚΟ ΠΛΕΓΜΑ
Authors: Κουτσούμπας Γιώργος
Published: January 2014

ΜΕΛΕΤΗΣΑΜΕ ΤΟ ΑΒΕΛΙΑΝΟ ΜΟΝΤΕΛΟ HIGGS Σ'ΕΝΑ ΧΩΡΟΧΡΟΝΙΚΟ ΠΛΕΓΜΑ. ΤΟ ΜΟΝΤΕΛΟ ΠΑΡΟΥΣΙΑΖΕΙ ΤΡΕΙΣ ΦΑΣΕΙΣ, ΤΙΣ ΦΑΣΕΙΣ COULOMB, HIGGS ΚΑΙ ΠΑΓΙΔΕΥΣΗΣ. ΒΛΕΠΟΥΜΕ ΟΤΙ ΛΕΙΤΟΥΡΓΕΙ Ο ΜΗΧΑΝΙΣΜΟΣ COLEMIN- WEINBERG. ΥΠΟΛΟΓΙΣΑΜΕ ΤΟ ΕΝΕΡΓΟ ΔΥΝΑΜΙΚΟ ΣΥΝΔΕΟΝΤΑΣ ΤΟ ΣΥΣΤΗΜΑ ΜΕ ΕΞΩΤΕΡΙΚΑ ΡΕΥΜΑΤΑ. ΣΤΗ ΦΑΣΗ HIGGS ΥΠΑΡΧΕΙ ΠΕΡΙΟΧΗ ΤΙΜΩΝ ΤΟΥ ΒΑΘΜΩΤΟΥ ΠΕΔΙΟΥ, ΟΠΟΥ ΤΟ ΕΝΕΡΓΟ ΔΥΝΑΜΙΚΟ ΔΕΝ ΜΠΟΡΕΙ ΝΑ ΟΡΙΣΤΕΙ. ΟΡΙΣΑΜΕ ΕΝΑ ΝΕΟ ΕΝΕΡΓΟ ΔΥΝΑΜΙΚΟ ΚΑΙ ΤΟ ΥΠΟΓΡΑΜΜΙΣΑΜΕ. ΕΧΕΙ ΤΗ ΜΟΡΦΗ ΤΟΥ ΗΜΙΚΛΑΣΣΙΚΟΥ ΔΥΝΑΜΙΚΟΥ ΚΙ ΕΤΣΙ ΕΠΙΤΡΕΠΕΙ ΝΑ ΣΧΗΜΑΤΙΣΟΥΜΕ ΜΙΑ ΕΙΚΟΝΑ ΤΟΥ ΜΗΧΑΝΙΣΜΟΥ HIGGS ΚΑΤΑ ΠΛΗΡΗ ΑΝΑΛΟΓΙΑ ΜΕ ΤΗΝ ΗΜΙΚΛΑΣΣΙΚΗ ΕΙΚΟΝΑ. ΤΕΛΟΣ, ΥΠΟΛΟΓΙΣΑΜΕ ΤΙΣ ΜΑΖΕΣ ΤΩΝ ΔΙΑΦΟΡΩΝ ΔΕΣΜΙΩΝ ΚΑΤΑΣΤΑΣΕΩΝ ΑΠΟ ΤΗ ΜΕΛΕΤΗ ΤΩΝ ΣΥΝΑΡΤΗΣΕΩΝ ΣΥΣΧΕΤΙΣΜΟΥ.
ΜΕΛΕΤΗ ΤΟΥ ΤΟΠΙΚΟΥ ΕΓΚΕΦΑΛΙΚΟΥ ΜΕΤΑΒΟΛΙΣΜΟΥ ΤΗΣ ΓΛΥΚΟΖΗΣ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΕΣΤΙΑΚΗ ΕΠΙΛΗΨΙΑ ΚΑΙ ΣΥΣΧΕΤΙΣΜΟΣ ΜΕ ΚΛΙΝΙΚΑ ΚΑΙ ΕΡΓΑΣΤΗΡΙΑΚΑ ΔΕΔΟΜΕΝΑ
Authors: Διαμαντόπουλος Νικόλαος
Published: January 2014

ΤΡΙΑΝΤΑ ΕΞΗ ΑΣΘΕΝΕΙΣ ΜΕ ΕΣΤΙΑΚΗ ΕΠΙΛΗΨΙΑ ΕΜΕΛΕΤΗΘΗΚΑΝ ΩΣ ΠΡΟΣ ΤΟΝ ΤΟΠΙΚΟ ΕΓΚΕΦΑΛΙΚΟ ΜΕΤΑΒΟΛΙΣΜΟ ΤΗΣ ΓΛΥΚΟΖΗΣ ΜΕ ΤΗΝ ΜΕΘΟΔΟ ΤΗΣ ΤΟΜΟΓΡΑΦΙΑΣ ΕΚΠΟΜΠΗΣ ΠΟΖΙΤΡΟΝΙΩΝ. ΟΙ ΑΣΘΕΝΕΙΣ ΕΙΧΑΝ ΕΠΙΣΗΣ ΠΛΗΡΗ ΕΛΕΓΧΟ ΚΛΙΝΙΚΟ, ΗΛΕΚΤΡΟΕΓΚΕΦΑΛΟΓΡΑΦΙΚΟ ΚΑΙ ΑΚΤΙΝΟΛΟΓΙΚΟ. ΟΙ ΑΣΘΕΝΕΙΣ ΕΠΑΣΧΑΝ ΑΠΟ ΑΝΘΙΣΤΑΜΕΝΗ ΣΤΗΝ ΦΑΡΜΑΚΕΥΤΙΚΗ ΑΓΩΓΗ ΕΠΙΛΗΨΙΑ . ΤΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΤΩΝ ΔΙΑΦΟΡΩΝ ΕΞΕΤΑΣΕΩΝ ΣΥΝΕΚΡΙΘΗΣΑΝ ΜΕΤΑΞΥ ΤΟΥΣ ΜΕ ΙΔΙΑΙΤΕΡΗ ΕΜΦΑΣΗ ΣΤΗ ΣΥΣΧΕΤΙΣΗ ΗΛΕΚΤΡΟΕΓΚΕΦΑΛΟΓΡΑΦΙΚΩΝ ΚΑΙ ΜΕΤΑΒΟΛΙΚΩΝ ΔΕΔΟΜΕΝΩΝ ΟΠΩΣ ΑΝΑΛΥΤΙΚΑ ΠΕΡΙΓΡΑΦΕΤΑΙ ΣΤΟ ΕΙΔΙΚΟ ΜΕΡΟΣ. (ΠΕΡΙΚΟΠΗ)