bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing the Efficacy of Pipelle Sampling as Outpatient Diagnostic Test in a Tertiary Care Hospital-Rawalpindi, 2020
Authors: Noor Nusrat , Anwar Rabiah , Akbar Rabia , Sadaf Ghazala , Yaqub Khan M
Published: January 2021

ABSTRACT

Objective:

To assess the effectiveness and enlist clinical factors, which may affect effectiveness of Pipelle sampling in diagnosing endometrial pathology in patients with abnormal uterine bleeding and Post-menopausal Bleeding.

Study Design:

‘Analytical Cross-Sectional’ study.

Place and duration:

Gynecology Department at Combined Military Hospital Rawalpindi, in collaboration with Histo-Pathology Department, of six months duration i.e. from 1st  December 2019 to 31st May 2020.

Patients and methods:

100 female patients of outpatient department with presenting complaints of either abnormal or post-menopausal bleeding were included in the study in the specified time frame. After informed written consent, Pipelle endometrial sampling was done on outpatient basis, and by consecutive sampling technique using lottery method, sample was sent for histopathological evaluation. Evaluated factors studied were:  indications for the procedure, age, parity, age of menarche.

Results:

Of the total patients evaluated, 91% (n=100) were non-malignant, while 4% (n=100) were malignant. Inadequate tissue was obtained in 5% samples. Most common histopathological findings among reproductive age group were Proliferative and Secretory phase endometrium 64% (n=100). While in Post-menopausal age group 4% (n=100) were Endometrial carcinoma on histopathology. Inadequate tissue samples 5% (n=100) were noted among the Post-menopausal group. 6% samples showed endometrial hyperplasia. Pipelle Endometrial Sampling had sensitivity and specificity, in diagnosing the endometrial pathologies is summarized in Table 3.

Conclusion:

Pipelle Endometrial Sampling is an effective, safe, simple and acceptable procedure for diagnosing endometrial pathology. It is cost effective requiring no anesthesia with high sensitivity and specificity for detecting endometrial pathology.
Topiramate and Pregabalin in Lumbar Radicular Pain. Is Topiramate a better option?
Authors: Ishfaq Asim , Ashraf Javaria , Haider Aimen
Published: January 2021

Abstract

Objective: To compare the efficacy of two anticonvulsant drugs topiramate and pregabalin on lumbar radicular pain and to find out whether topiramate is a better option or not.

Study design: Experimental study.

Place and Duration: Department of Neurosurgery, Combined Military Hospital Lahore. January 2020 - March 2020.

Patients and Methods: 60 patients of both gender divided in two groups of 30 each were included. Patients were assessed based on subjective impairment scale of oswestry disability index. Maximum score was calculated in percentage with higher score pointing to greater disability. Both drugs were given in low starting once daily dose, 75 mg for pregabalin and 25 mg for topiramate for two weeks followed by twice daily dose for two more weeks in patients not getting pain relief. 

Results: Male to female ratio of 4:1 in both groups. Age range of 27-77 years (41.5+12.45) for pregabalin and 22-74 years (41.6+14.6) for topiramate group. Baseline demographics and pre drug pain measurement index were identical amongst two groups. Oswestry disability index was 49.2+18.3 pre drug and post drug 41+16.4 for pregabalin (p<0.01). For topiramate it was 43.6+37.9 pre drug and 37.9+17.3 post drug (p <0.01).

Conclusion:    Both pregabalin and topiramate are effective in radicular pain management,  and topiramate is not better but still a viable option as an alternative to pregabalin.
Comparison of Paricalcitol (I.V) and Alfacalcidol (I.V) in Treatment of Secondary Hyperparathyroidism (SHPT) in Hemodialysis Patients
Authors: Qaisar Mansoor Abbas , Abideen Zain Ul , Chattah Fateh Sher , Nadeem Muhammad , Hafeez Zahid
Published: January 2021

ABSTRACT

 

Objective of study: To Compare the efficacy of Alfacalcidol (I.V) and Paricalcitol (I.V) for the treatment of secondary hyperparathyroidism  (SHPT)  in hemodialysis patients.

Materials and Methods: An open-label randomized clinical trial  carried out to compare the efficacy of intravenous paricalcitol and alfacalcidol. We recruited 80 patients with end stage renal  disease receiving  maintenance hemodialysis in a tertiary care hospital dialysis unit. The participants were randomly divided into two  groups. A wash out period of one week was decided for each patient in which he/she did not receive any medication for treatment of hypocalcemia, hyperphosphatemia or secondary hyperparathyroidism. Afterwards, patients  received  expanding dosage of alfacalcidol or paricalcitol  for a time of about four months and then after a further wash out period of one week, each group received  opposite treatment (paricalcitol or alfacalcidol) for further  four months (16 weeks).

Results: The analyzed data for the same end points revealed no difference between the two groups. No significant statistical difference in terms of  calcium levels in both groups was noted. The study also found no big difference  in the ability of both drugs to treat secondary hyperparathyroidism, while keeping serum phosphate and calcium levels inside the desired range. The study also found no distinction in the frequency of hypercalcemia and  hyperphosphatemia as a side effect of Vitamin D analogue’s treatment.

 

Conclusion: The study concludes that alfacalcidol and paricalcitol are equally effective in treatment of secondary hyperparathyroidism in dialysis population. Since Paricalcitol is expensive as compared to alfacalcidol, in an economically challenged country like Pakistan, Alfacalcidol can be a better  choice when treating SHPT as we did not  find any gross difference in the ability of two drugs to restrict SHPT.

 

Keywords:  Alfacalcidol, Paricalcitol, Secondary hyperparathyroidism, Hemodialysis.
Antidiabetic Effects of Aloe Vera Whole Leaf Extract and Sitagliptin in Streptozotocin-induced Diabetic Rats
Authors: Javaid Sobia , Waheed Akbar
Published: January 2021

Introduction: Aloe Vera, a perennial herb, is being used since ancient times for the cure of various diseases and is recently being used in curing diabetes due to the synergistic activity of its over 75 biologically active ingredients. The objective of the study was to compare the antidiabetic effects of Aloe Vera whole leaf extract with standard antidiabetic drug Sitagliptin on streptozotocin-induced diabetic rats.

Material and Methods: The present study was RCT, conducted at the Department of Pharmacology, Islamic International Medical College, Rawalpindi in collaboration with the National Institute of Health, Islamabad, Pakistan, from September 2019 to August 2020. A total of 40, young Sprague Dawley rats weighing between 220-250 grams were taken and randomly divided into Group A (Normal Control) and group B. After induction of Type-2 Diabetes, group B was further subdivided into 3 groups with 10 rats each: Group B1 (Diabetic Control), Group B2 (Aloe Vera whole Leaf Extract treated), GROUP B3 (Sitagliptin treated). Terminal Sampling was done to measure FBS and HbA1c on Day 60. Statistical Analysis was done by applying SPSS version 25. A one-way ANOVA test was used for assessing any difference in the mean values. Post-hoc Turkey analysis was conducted to compare any inter-group mean differences. P-value of <0.05 was considered significant.

Results: On completion of the study, at Day 60, mean FBS values for Rats in Group A were 82.40 mg/dl, for Group B1 498.40 mg/dl, for Group B2 89.30 mg/dl, and Group B3 93.00 mg/dl respectively. Mean HbA1c results for rats after terminal sampling in Group A were 3.71%, Group B1 11.84%, Group B2 4.02%, B3 3.73%. Rats in each of Group B2 (Aloe Vera whole leaf treated) and Group B3 (Sitagliptin treated) had a significant reduction in fasting blood sugar and HbA1c levels in comparison to Group B1 (diabetic control), with no statistically significant intergroup differences in results of Group A, Group B2 and Group B3.

Conclusion: Aloe Vera whole leaf extract significantly decreased fasting blood glucose and HbA1c levels with almost similar efficacy to Sitagliptin in diabetic rats.
Microdebrider-Assisted Turbinoplasty and Submucosal Diathermy for Inferior Turbinate Hypertrophy: A Randomized Clinical Trial
Authors: Arshad Muhammad , Ashfaq Ahmed Hasan , Rasheed Muhammad Tayyab , Khawaja Mahwash , Langove Muhammad Nadeem , Khan Muhammad Sheharyar
Published: January 2021

ABSTRACT

Background: Nasal obstruction is a common presenting problem which can lead to symptoms like sleep disturbances, mouth breathing, oral cavity dryness. Hypertrophied inferior turbinate is a common cause of nasal obstruction. Microdebrider assisted turbinoplasty and submucosal diathermy are widely used methods for patients who fail to respond to medical therapy to relieve obstruction. The aim of the study was to compare two methods in terms of relief of nasal obstruction, reduction in sneezing and post-operative complications.

Material & Methods: This randomized clinical trial was conducted at ENT Department, Benazir Bhutto Hospital Rawalpindi, Pakistan for one year from 01-03-2018 to 28-02-2019. One hundred and twenty patients were randomized to into either MAT and SMD groups each with 60 patients. Nasal obstruction symptom evaluation score system (NOSE) was used to access relieve from obstruction and sneezing. SPSS 22, online chai square and fisher exact test calculators were used to analyze the data.

Results:

Two groups were comparable for age and gender. After 3 months of treatment, all patients in MAT group and 51 patients in SMD group were completely relieved from obstruction. At two weeks follow up 37(61.57%) patients in MAT group had grade 0 obstruction compared with 14 (23.33%) in SMD group and this difference was significant (p value .000). at one month follow up 55 (91.67%) patients in MAT while 46 (76.67%) had completely relieved obstruction and this difference was significant ( p value .024). Not all patients showed reduction in sneezing in both groups. 37 patients in MAT and 25 patients in SMD group had completely relieved from sneezing at third month follow up with MAT group showing significantly more patients with sneezing reduced at one month follow up. Crust formation was most seen complication in both groups, more with SMD group at two weeks follow up which responded to treatment alkaline nasal douches and crust removal.

 

Conclusion:

MAT gives better in terms of nasal obstruction relieved, reduction in sneezing and less complications than SMD  procedure.

KEYWORDS: Microdebrider; Diathermy; Turbinates; Nasal obstruction
A clinico-mycological spectrum of superficial mycoses of scalp in pediatric population
Authors: Zeeshan Faiza , Uddin Fakhur , Khan Bahram , Zehra Talat , Razzak Sadaf , Irshad Zareen
Published: January 2021

Objective: A clinico-mycological study was conducted to assess the profile of dermatophytes and non-dermatophytes in patients with superficial mycoses of scalp.

Methods:  This Descriptive cross sectional study was conducted at Department of Microbiology, Basic Medical Sciences Institute, in collaboration with Department of Dermatology, Jinnah Postgraduate Medical Centre, Karachi. The study was carried out from May 2019 to September 2019. A total of 114 children were enrolled in the study having a clinical diagnosis of superficial mycoses of scalp. The hair specimens and scales from the scalp were collected. The specimens were processed for wet mounts (KOH and CFW staining) and mycological culture.  .

Results: The most common clinical presentation was found to be dermatophytoses (28%). Non-dermatophytoses was seen in 16.1% cases, while 55.2% cases were culture negative. The most common isolated dermatophyte was Trichophyton violaceum (35.4%), while among non-dermatophyte molds, Aspergillus spp accounted for 45% of cases.

Conclusion: The unambiguous diagnosis of scalp mycoses can be made by mycological culture and conventional techniques like KOH mounts and CFW staining.

Keywords: Calcoflour white stain, Dermatophytes, KOH mount, Tinea capitis
Predictive Efficacy of Haematological Biomarkers in COVID-19 infection
Authors: Nadeem Ikram,Asma Nafisa, Rabia Anjum,Naeem Akhter Nadeem Ikram,Asma Nafisa, Rabia Anjum,Naeem Akhter
Published: January 2021

Introduction: The ongoing Corona Virus Pandemic is linked with high rates of morbidity and mortality globally. Early and effective predictors of clinical outcomes are urgently required to develop effective management protocols.Objective: To investigate the predictive efficacy of haematological biomarkers in Covid -19 infectionMethods: Blood samples were drawn from COVID‐19 infected pneumonia patients. Baseline clinical information was collected and quantification of hemostatic variable was done.  Laboratory data both groups expired and recovered were compared using t- test, Mann Whitney- U test, chi squared-test and Kruskal Wallis test. Multivariate regression analysis was performed to determine the independent contribution of haematological variable in Covid19 related mortality. Receiver operating characteristic curve were drawn to find the predictive efficacy of significantly related parameters.Results: Out of 191 patients 68.1%  were male. D‐dimer (median 800 ng/mL; IQR 200‐3200) and NLR (median 10.40; IQR 3.20-22.80) were found to be predominantly raised and significantly correlated with Covid mortality in multivariate regression analysis. The optimum cutoff value of D-dimer to predict in-hospital mortality was 450 ng/ml with a sensitivity of 71.6% and a specificity of 95.8%. The optimum cutoff value of NLR to predict in-hospital mortality was 5.450 with a sensitivity of 70.1% and a specificity of 71%.Conclusion: D-dimer and NLR could be used as the signiﬁcant indicators in predicting the mortality of COVID-19.
The Expansion of Wronskian Hermite Polynomials in the Hermite Basis
Authors:   Google Z&, Grosu Codruţ ,   #252,   rich, Switzerland, Grosu Corina ,   Politehnica University of Bucharest, Romania
Published: January 2021

We express Wronskian Hermite polynomials in the Hermite basis and obtain an explicit formula for the coefficients. From this we deduce an upper bound for the modulus of the roots in the case of partitions of length 2. We also derive a general upper bound for the modulus of the real and purely imaginary roots. These bounds are very useful in the study of irreducibility of Wronskian Hermite polynomials. Additionally, we generalize some of our results to a larger class of polynomials.
Assessment of Urinary Kidney Injury Molecule-1 as an Indicator of Early Renal Insult in Children with Cystic Fibrosis
Authors: Shahin Walaa , Bader Ahmed , Ahmed Rawdah , Alattar Mona , Alfalaki Mona , Rabie Walaa
Published: January 2021

BACKGROUND: The risk of acute kidney injury in cystic fibrosis (CF) patients is due to renal tubular affection by CFTR gene.
AIM: Our study aimed at early detection of renal impairment in CF patients, to enable careful monitoring and adjustment of nephrotoxic medications.
METHODS: Fifty patients with CF were enrolled in our study; they were age- and sex-matched to 40 healthy control children. All subjects were screened by urine analysis, measurements of kidney function tests, fractional excretion of sodium, β2-microglobulin (beta-2-M) excretion, and renal ultrasound examination. Urinary kidney injury molecule-1 (KIM-1) was assayed using ELISA technique.
RESULTS: Both urinary beta-2-M and KIM-1 concentrations were significantly higher in CF patients compared to the control group (p < 0.001). The duration of the disease was significantly positively correlated with the urinary beta-2-M and KIM-1 levels (r = 0.6 and 0.7, respectively; p < 0.01).
CONCLUSIONS: Our results showed that urinary KIM-1 can be considered as a sensitive early indicator of acute renal injury.
Les paradoxes dans un établissement de santé : reconstruire du sens par l’innovation managériale
Authors: Albert-Cromarias Anne , Santos Catherine Dos
Published: January 2021

Les établissements de santé connaissent depuis plusieurs années un tournant gestionnaire qui se traduit par une recherche de rationalisation et un risque de focalisation sur la dimension économique. Dans ce contexte, ils font face à des tensions paradoxales qui mettent à mal le sens de leur action. Notre problématique est alors la suivante : peut-on répondre aux paradoxes d’un établissement de santé par l’innovation managériale en s’appuyant sur la (re)construction de sens ? La recherche s’appuie sur l’étude d’un Centre de Lutte Contre le Cancer (CLCC) et est fondée sur une analyse documentaire et des entretiens à visée compréhensive. Les résultats montrent que l’innovation managériale comme réponse aux paradoxes permettrait de recréer collectivement du sens.
Les illusions perdues de l’arrosage connecté intelligent : quand un intermédiaire échoue à accompagner le développement d’une innovation dans un contexte traditionnel
Authors: Lambert Charlène , Tellier Albéric
Published: January 2021

Cet article s’intéresse à l’innovation technologique en métier traditionnel au travers du cas d’un projet d’arrosage connecté intelligent dans le métier traditionnel du paysage. Ce projet collectif, porté par un intermédiaire d’innovation facilitant les étapes du processus d’innovation, a finalement été abandonné à la suite de sa phase de conception. Les réticences culturelles liées à l’attachement à la tradition des professionnels et du marché sont généralement invoquées pour expliquer l’échec d’innovations trop radicales. Nous montrons, pour notre part, que l’intermédiaire d’innovation engagé dans ce contexte a des rôles spécifiques à jouer dans la gestion de la tradition et l’apprentissage.
L’impact de la RSE sur la relation entre la gestion de résultat et la qualité du reporting financier et extra-financier : le cas français
Authors: Fourati Abdelaziz , Jeriji Maher , Louhichi Waël
Published: January 2021

Ce papier examine la relation entre la gestion de résultat (GR) et la qualité du reporting financier et extra-financier. Nous avons étudié l’impact des trois piliers de la performance RSE séparément en analysant le contenu de 255 documents de référence et rapports RSE de 51 sociétés françaises appartenant à l’indice SBF120. Nos résultats révèlent que les pratiques de GR limitent la qualité du reporting financier et extra-financier et que la performance RSE, notamment la gouvernance, améliore la qualité du reporting RSE. En outre, nous avons démontré que la performance environnementale augmente le recours aux pratiques de GR.
Développer les talents des non-cadres par une politique d’intégration des primo-arrivants : le cas d’une entreprise publique en mutation
Authors: Garcia Jean-François , Brillet Franck , Montargot Nathalie
Published: January 2021

Dans les pratiques organisationnelles, le management des talents est souvent associé au personnel cadre d’organisations privées et relié à des dispositifs issus de la GPEC. Cet article propose de questionner ce lien traditionnel. Les auteurs interrogent qualitativement la relation dyadique entre développement des talents non-cadres et politique d’intégration d’une entreprise publique. Les résultats de l’étude montrent qu’en permettant aux primo-arrivants d’être acteurs de leur propre développement, ce dispositif renouvelle « l’offre RH » en matière d’accompagnement des talents.
Augmenter les raisonnements constructifs : une compétence transversale sous-utilisée par les managers pour innover
Authors: Vachon Marc
Published: January 2021

Dans le cadre d’une recherche reliant la gestion des ressources humaines et l’innovation, nous posons la question suivante : quelle compétence transversale les managers doivent-ils utiliser pour innover ?… En réponse, nous préconisons aux managers d’augmenter les raisonnements constructifs, qui sont presque deux fois moins utilisés que les routines défensives. Cette préconisation nous a conduits à créer une formation à l’utilisation des raisonnements constructifs.
Reporting volontaire en matière de responsabilité sociale : un effet contrasté de l’assurance RSE
Authors: Lajmi Amira , Nekhili Mehdi , Nagati Haithem , Paché Gilles
Published: January 2021

L’article analyse le rôle modérateur que joue l’assurance RSE, en tant que mécanisme de gouvernance axé sur le développement durable, dans la relation entre le reporting volontaire en matière de responsabilité sociale et la valeur de marché de l’entreprise. À partir des données recueillies auprès d’un échantillon d’entreprises françaises du SBF 120 entre 2001 et 2011, les résultats indiquent que la valeur de la communication volontaire d’informations relatives à la RSE est perçue négativement et que le recours à une assurance RSE par un organisme tiers indépendant n’est pas nécessairement pertinent. Les auteurs constatent toutefois que les actionnaires ne portent pas le même jugement sur chaque dimension du reporting RSE, et ils ne perçoivent l’intérêt de recourir à une vérification sociétale qu’en cas de doute sur la crédibilité des informations communiquées.
La digitalisation du recrutement post-bac : ses enjeux et ses limites. Peut-on parler d’innovation ?
Authors: Luangsay-Catelin Carine , Roybier-Mtanios Rajaa
Published: January 2021

L’objet de la présente recherche est d’étudier comment par son rôle restructurant, le numérique, a remodelé le processus de recrutement des étudiants à destination des formations Post-Bac. Aussi, après avoir présenté une brève revue de la littérature sur les transformations du service public, en mettant en évidence les enjeux de la digitalisation, nous nous tournerons sur le processus de recrutement des étudiants dans l’enseignement supérieur en France. En effet, nous examinerons en quoi la mise en place et les adaptations de ce dernier peuvent constituer une innovation permettant de renforcer l’efficacité et l’efficience du service public ?
Quel modèle d’émergence pour les start-up des éco-industries : David un futur Goliath ou David avec Goliath ?
Authors: Petzold Stéphanie , Fonrouge Cécile
Published: January 2021

Dans les industries verdissantes, des start-up, tels des "David" tentent de trouver leur place à côté des "Goliath" qui mettent du vert dans leur stratégie. Quel modèle d’émergence ces start-up sont-elles en mesure d’adopter? Pour répondre à cette question deux lectures complémentaires sont proposées : celle en termes de design dominant et celle de type évolutionniste. Un cas de l’éco-industrie en France permet d’étudier en profondeur le cheminement stratégique d’une start-up. Les résultats mettent en évidence des facteurs de contingence qui pousseraient les start-up des éco-industries soit vers un modèle soit vers l’autre.
Le rôle stratégique du chef prescripteur dans le tourisme gastronomique : le cas des produits locaux
Authors: Salvador Marielle , Gandia Romain
Published: January 2021

Le tourisme gastronomique profite aux produits locaux, mais saisir cette forme de promotion est difficile pour les producteurs. L’influence de la prescription du chef étoilé par une collaboration avec le producteur sur l’engagement du client est analysée afin de développer de nouveaux business model. Celui-ci dépend de la forme de la prescription, de la nature du produit et de la pédagogie du chef auprès des clients. Une co-prescription enrichit la proposition de valeur et renforce l’engagement dans l’acte d’achat.
L’impact des différents degrés de la culpabilité sur l’efficacité des appels aux dons charitables au profit des enfants malades du cancer. L’effet du sens de responsabilité sur la culpabilité ressentie
Authors: Chaieb Asma , Gharbi Abderrazak
Published: January 2021

Cet article porte sur l’impact de trois formats publicitaires à différents niveaux d’intensité inscrits dans le registre de la culpabilité dans les appels aux dons charitables soutenant la cause des enfants atteints du cancer. Les résultats ont montré que la relation entre les stimuli culpabilisants et la culpabilité ressentie est curvilinéaire (U inversé). Il a été également démontré que le sens de responsabilité déclenché par l’affiche moyennement culpabilisante est le plus élevé. Ce sens de responsabilité contribue significativement à l’intensité de la culpabilité ressentie par les donateurs potentiels et aux intentions de dons exprimées par ceux-ci. Enfin, les résultats ont montré que la perception de manipulation, qui pourrait être engendrée par l’affiche fortement culpabilisante, agit négativement sur la culpabilité ressentie, ainsi que sur l’intention de donation.
L’entreprise, la comptabilité et le droit : enjeux, risques et perspectives au regard de la loi Pacte
Authors: Bourgeois Clémentine , Ouvrard Stéphane
Published: January 2021

Suite à la publication de la loi Pacte 1 , la vision actionnariale de la gouvernance véhiculée par les IFRS 2 va-t-elle évoluer ? En ouvrant la voie à un modèle de gouvernance élargi, la loi Pacte et les différents rapports qui l’ont précédé réhabilitent le rôle social et sociétal de l’entreprise. Suivant ses propres objectifs, l’entreprise incarne un « objet d’intérêt collectif » (Notat et Sénard, 2018).
L’amélioration de la qualité du management comme facteur d’implication et de fidélisation du personnel des EPHAD en milieu rural. Cas de 3 recherche-interventions
Authors: Combaudon Christophe , Fouré-Joopen Helga
Published: January 2021

Le vieillissement de la population en France aura inévitablement des conséquences sur sa future société et notamment sur la considération des personnes âgées et leur place dans son modèle social actuel. Les établissements d’hébergement pour personnes âgées dépendantes (EHPAD), équivalant à des maisons de retraite médicalisées, ont été mis en place pour répondre à un véritable besoin concernant les soins de longue durée et de services aux personnes âgées. Ces résidences présentent cependant leurs limites au regard de l’implication des personnes soignants. En nous basons sur trois cas d’interventions, nous considérons que la situation défaillante actuelle est très souvent due à un manquement de la part du management aux besoins pas seulement budgétaires mais également sociales et proposons des pistes de progrès.
Proposition d’une échelle de mesure du sensegiving en période de changement organisationnel
Authors: Desgourdes Clément , Leroy Daniel
Published: January 2021

Les périodes de changements organisationnels sont des étapes cruciales de l’évolution des organisations nécessitant un processus de création de sens de la part des individus pouvant être déterminant dans le succès du changement souhaité. Dans ce cadre, notre article propose la création d’une échelle de mesure du sensegiving en sept items permettant d’évaluer la création de sens des managers pour leurs salariés en période de changement organisationnel. Nous testons ensuite notre modèle sur le bien-être au travail des salariés en période de changement en utilisant l’échelle de mesure positive du bien-être au travail (EPBET) de Biétry et Creusier (2013).
Les transformations organisationnelles en contexte africain: une analyse des usages des réseaux sociaux numériques par la force de vente des entreprises de services
Authors: Sone Mbassi Alain Noël
Published: January 2021

Cet article analyse les transformations organisationnelles consécutives aux usages des réseaux sociaux numériques par la force de vente. Il mobilise la littérature en marketing et en systèmes d’information ainsi que la théorie structurationniste comme cadre théorique. Il examine le cas de deux entreprises de services au Cameroun. Les résultats font état d’une synergie des canaux de communication qui améliore la performance de la force de vente dans les deux entreprises. Cependant, les transformations qui en découlent sont de natures différentes et permettent d’identifier deux modèles présentant des caractéristiques opposées. Des recommandations sont ensuite émises.
Attachement conjugal et succès de l’entreprise copreneuriale : une approche conceptuelle
Authors: Villéger Amélie
Published: January 2021

Les copreneurs sont des couples qui possèdent et dirigent ensemble une entreprise. Malgré leur poids économique, leur étude scientifique a longtemps été négligée et l’appréhension de l’impact de la nature du lien conjugal sur le succès de l’entreprise a été oubliée. Cette recherche conceptuelle propose de participer au comblement de cette lacune en appliquant, pour la première fois, les préceptes de la théorie de l’attachement au contexte copreneurial. Le style d’attachement conjugal est pressenti comme pouvant influencer le succès de l’entreprise copreneuriale.
Adaptation sur mesure des instruments d’audit interne aux attributs structurels des collectivités territoriales marocaines
Authors: El Kadiri Boutchich Driss , Gallouj Nizar
Published: January 2021

Ce papier traite du problème d’adaptation des instruments d’audit interne aux attributs structurels des collectivités territoriales marocaines. Fondée sur une étude empirique portant sur un échantillon de 81 communes marocaines, cette recherche a recours à la contingence configurationnelle qui transcende la contingence traditionnelle basée sur des associations bi-variées entre l’objet étudié et ses attributs. La contingence configurationnelle est mêlée à la contingence générique, l’une des bases du constructivisme générique qui est la posture épistémologique adoptée par le présent travail. Comme méthode opératoire de réalisation de cette recherche l’analyse des correspondances multiples est utilisée. Ses résultats montrent que tous les prototypes instrumentaux modelés selon les caractéristiques des collectivités territoriales portent en leur sein des gènes socioéconomiques.
Apports de la recherche-intervention dans la conception d’un parcours de soins
Authors: Giusti Igor , Terramorsi Patrice
Published: January 2021

Cet article tire les enseignements d’un projet de recherche-intervention réalisé, à l’initiative de l’Agence Régionale de Santé de Corse, dans le but d’apporter une réponse aux contraintes posées par l’accès aux soins de réadaptation cardiaque pour les patients habitant au sein de territoires ruraux. Il reviendra plus particulièrement sur les apports de la recherche-intervention comme méthodologie de transformation des connaissances et des relations nécessaires au développement d’un mode d’organisation innovant.
Pôle d’activité médicale et coopération médico-économique : une nouvelle structure organisationnelle à l’épreuve de l’incertitude des préférences
Authors: Vallejo Jimmy
Published: January 2021

Depuis plusieurs années, l’hôpital public français est sujet à un tournant gestionnaire et à la mise en place depuis 2005 d’une nouvelle gouvernance : la création des pôles d’activité́ médicale. L’idée est de rapprocher les logiques gestionnaires et médicales, à travers le développement d’un monde médico-économique, en favorisant la coopération entre ces deux logiques. L’objectif de cette recherche est de s’interroger sur les conditions de la coopération entre gestionnaires et médecins à travers les pôles, à partir d’une mobilisation innovante du cadre théorique de l’anarchie organisée, et de l’étude de cas d’un grand CHU.
Three Experimental Designs Testing Orthopedic Casting Material Strength
Authors: Callahan Dennis J , Daddario Nicholas , Williams Stephen , Walter Norman E
Published: January 2021

ABSTRACT: Three experimental designs are described which were used in assessing the strength of orthopedic casts. The clinical relevance of the testing methods is discussed. The complex structure of the orthopedic casting material is also emphasized.
Effect of water reservoirs types on the prevalence and antibiotic resistance profiles of Pseudomonas aeruginosa isolated from bathroom water in hospitals
Authors: Kusuma Sri Agung Fitri , Rostinawati Tina , Hendriani Rini , Budiman Muhammad Faisal , Parwati Ida
Published: January 2021

This study was aimed to isolate and characterize Pseudomonas aeruginosa antibiotic resistance profiles that isolated from bathroom water of five hospitals in Bandung, Indonesia, with different types of water reservoirs. Total of 25 water samples from bathrooms of five hospitals were collected and analyzed for the existence of P. aeruginosa colonies on the surface of MacConkey agar media using a streak plate method and identified using phenotypic identification and a series of biochemical tests. All P. aeruginosa isolates were tested against ceftazidime, piperacillin/tazobactam, ciprofloxacin, meropenem, and gentamicin containing in paper disc, using the agar diffusion method. Of all samples, the total number of P. aeruginosa isolates was less than that of non-P. aeruginosa. In hospitals that use permanent bathtubs, a greater total bacterial count was obtained than those using pails. From 110 isolates, 14.54% were multidrug resistance antibiotics. The majority of the resistant isolates were from hospital B with permanent bathtubs. Of 25 isolates from that hospital, P. aeruginosa isolates were resistant to ceftazidime (20%), piperacillin/tazobactam (4%), ciprofloxacin (20%), and gentamicin (20%). The multiple antibiotic resistance index value of P. aeruginosa isolates was 0.4–0.6. Thus, it can be concluded that the bathroom wáter in the hospital with permanent bathtubs were potential reservoirs of antibiotic-resistant P. aeruginosa.
Role of dyslipidemia in the development of early-onset preeclampsia
Authors: Al-Maiahy Thabat J. , Al-Gareeb Ali I. , Al-Kuraishy Hayder M.
Published: January 2021

Preeclampsia (PE) is a gestational-related disease presented with hypertension, peripheral edema, and proteinuria after 20 weeks of gestation. In PE, there are various metabolic changes like dyslipidemia. In addition, both PE and dyslipidemia are associated with changes of platelet indices. Thus, objective of the current study was to illustrate the potential role of dyslipidemia and platelet changes in pregnant women with PE. This case–control study involved 37 preeclamptic pregnant women as compared to 24 healthy pregnant women as controls. Blood pressure profile, lipid profile, proteinuria, and platelet indices were measured. Blood pressure profile was higher in preeclamptic pregnant women as compared to the controls (P < 0.01). There was a significant dyslipidemic status in preeclamptic pregnant women compared with the controls (P < 0.01). Platetetcrit (PCT) and platelet count (PC) were lower in preeclamptic pregnant women compared with the controls (P = 0.001). On the other hand, platelet distribution width (PDW), mean platelet volume (MPV), and platelet-large cell ratio (P-LCR) were higher in the pregnant women with PE as compared with the controls (P = 0.001). PCT and PC were insignificantly linked, while P-LCR, MPV and PDW were significantly correlated with total cholesterol, triglyceride, low-density lipoprotein (LDL)/high-density lipoprotein (HDL) ratio, systolic blood pressure, DBP, and MAP in preeclamptic patients compared with women of normal pregnancy. Both dyslipidemia and alterations in the platelet indices are correlated with blood pressure profile in PE. High MPV and PDW in association with high LDL/HDL ratio in pregnant women herald risk of PE.
Antibiofilm effect of C-10 massoia lactone toward polymicrobial oral biofilms
Authors: Utami Diyah Tri , Tunjung Pratiwi Sylvia Utami , Spaink Herman P. , Haniastuti Tetiana , Hertiani Triana
Published: January 2021

This study is aimed to test the efficacy of C-10 Massoia lactone in oral polymicrobial degradation. Polymicrobial of Streptococcus sanguinis, Streptococcus mutans, Lactobacillus acidophilus, and Actinomyces viscosus were studied. C-10 Massoia lactone against biofilm degradation was investigated using modified crystal violet for biofilm staining. The effectiveness of C-10 Massoia lactone against biofilms was calculated by the minimum biofilm inhibitory concentration (MBIC50) and the minimum value of biofilm eradication concentration (MBEC50). Scanning electron microscope was used to study biofilm cell viability and morphological changes. The results showed a degradation effect of C-10 Massoia lactone against mature oral polymicrobial at 0.25% v/v. C-10 Massoia lactone can degrade polymicrobial biofilms of S. mutans, S. sanguinis, L. acidophilus and A. viscosus. This compound can destroy the extracellular polymeric substances (EPS) of polymicrobial biofilms. The potential application of C-10 Massoia lactone for anti-polymicrobial medication should be applied in such a way that any negative effects are minimized. Further research is needed to confirm the findings of this study.
Modification of Anti-acne Bawang Dayak (Eleutherine bulbosa (Mill.)Urb.) Cream to Propionibacterium acnes
Authors: Ardhany Syahrida Dian , Putra Candra Dwi , Novaryatiin Susi
Published: January 2021

Bawang dayak is one of the traditional medicines in Central Kalimantan, used to treat acne vulgaris. Previous research reported that a cream made with bawang dayak extract's active ingredient could inhibit Propionibacterium acnes' growth. However, bawang dayak has a pungent odor that causes discomfort, where the cream separates after 3 days of storage, which decreases its potency. This study aims to improve the quality of the anti-acne cream formulation of bawang dayak extract from previous studies with the addition of cinnamon, honey, and peppermint. The modified formula of bawang dayak extract cream was evaluated and tested for its antibacterial activity in vitro. The results showed an increase in the organoleptic test, especially the smell, which gave a more comfortable fragrance than the previous formula. The pH measurement of the cream shows the results suitable for topical applications. However, the homogeneity observations show that all the formulas are homogeneous, seen from uniform colors but contain coarse grains. The antibacterial activity test of all cream formulations against P. acnes showed inhibition zone diameter between 14.85 and 17.10 mm, all of which were moderate and larger than previous studies. It can be concluded that the modification of the cream formula with the active ingredient of bawang dayak extract showed an increase in the inhibition zone against P. acnes and improved organoleptic properties.
Relaxation effects of Eriobotrya japonica toward tracheal smooth muscle via action mechanism on histamine-1 receptor and phosphodiesterase-5 enzyme
Authors: Marianne Marianne , Husori Dadang Irfan , Nasution Rosnani , Wismar Annisa , Pranata Aspan Ali
Published: January 2021

The Eriobotrya japonica leaves have the activity to relax the smooth muscle in the respiratory tract. However, the mechanism of action due to that activity has never been carried out. This study aims to determine the relaxation effects of E. japonica leaves extract in the isolated trachea of the guinea pigs through the inhibition of the histamine-1 (H-1) receptor and the phosphodiesterase-5 (PDE-5) enzyme. The determination of the relaxation effects was carried out by using histamine to contract smooth muscle within the tracheal tract, followed by adding cumulative concentrations of extract. Michaelis–Menten kinetics equation was used to determine the antagonist type of extract toward H-1 receptor. The understanding of mechanism of action of the extract toward PDE-5 enzyme was performed by incubating the smooth muscle using sildenafil. The percentage value of responses, originated from the relaxation effect of the extract toward the trachea was analyzed by using the t-independent test. The result showed that the extract was able to relax the smooth muscle, which was contracted by histamine, and there was a positive correlation between concentration and relaxation effect (P < 0.05; r = 0.973). The extract also antagonized the histamine as a noncompetitive antagonist. The incubation within the trachea with sildenafil demonstrated equal relaxation effect, produced by the extract. It can be concluded that E. japonica extract had relaxation effect within the isolated trachea as antagonist noncompetitive toward H-1 receptor and inhibitor of the PDE-5 enzyme.
Bovine sponge amnion stimulates socket healing
Authors: Faadhila Tabita Imaniar , Valentina Martha Nadila , Munadziroh Elly , Nirwana Intan , Soekartono Helal , Surboyo Meircurius Dwi Condro
Published: January 2021

Bovine sponge amnion (BSA) is made from bovine amniotic membrane, which contains several growth factors with the ability to suppress inflammation and stimulate the healing process. The healing process of the socket is clinically marked by the proliferation of fibroblasts, formation of new blood vessels, and closure of the wound site. Fibroblasts and new blood vessels are the common histological indicators of tissue regeneration. Twenty-four lower anterior teeth were extracted from the rats. The socket was then applied with BSA and sutured, while a control group was only sutured. The animals were scarified 3, 7, and 14 days after application, and the mandibular was isolated. Histological analysis of socket tissue used the staining of hematoxylin and eosin to analyze the new blood vessels and fibroblasts. An independent t-test was used to analyze the fibroblasts and new blood vessels in each group, with P < 0.05 considered as significant. The number of fibroblasts is higher in the BSA group compared others groups at 3, 7, and 14 days (P < 0.05). The new blood vessel count is higher compared to the control group at only 3 and 7 days (P < 0.05). BSA aids the regeneration of the socket after tooth extraction by stimulating fibroblast proliferation and formation of new blood vessels.
Natural product of gambier (Uncaria gambier Roxb) extracts to counter against hepatotoxicity effects due to monosodium glutamate induction in male mice
Authors: Pane Yunita Sari , Machrina Yetty , Hasan Sufitni , Lumongga Fitriani , Yunanda Yuki
Published: January 2021

Monosodium glutamate (MSG) is often added in foods to enhance the flavor. It has adverse effect to body organs. Natural remedies, such as: gambier have been known for generations used to improve health. Substances contained in gambier, i.e.: catechins are believed to reduce the occurrence of hepatotoxicity. The study aims to analyze the effects of gambier in reducing the hepatotoxicity of MSG. This study with a posttest only control group design. Mice amount 25 (5 groups, n = 5/group). All interventions are given orally for 4 weeks. At the end of the study, it carried out euthanasia taken the liver of mice to made histopathology preparations then examine by light microscope, ×400, ×5 view field. Liver damage was found in each group with various levels of histological appearance:(I) 2 normal, 2 minimal, 1 moderate and none severe; (II) none normal, 1 minimal, 3 moderate and 1 severe; (III) 1 normal, 4 minimal, none moderate and severe;, (IV) 2 normal, 3 minimal, none moderate and severe; and (V) 4 normal, 1 minimal, none moderate, and severe. The data were analyzed using Kruskal–Wallis test. The level of liver damage among all groups was significantly different (p = 0.017). The same on the Dunn test also showed the level of liver damage in Group-II to compare with other groups (p < 0.05). The present study proves that Gambier (Uncaria gambier Roxb) can reduce occurrence of hepatotoxicity caused by MSG.
Synergistic effect of ampicillin and dihydrobenzofuran neolignans (myticaganal C) identified from the seeds of Myristica fragrans Houtt. against Escherichia coli
Authors: Keawchai Kanokrat , Chumkaew Parinuch , Permpoonpattana Patima , Srisawat Theera
Published: January 2021

The present study was designed to enhance the antibacterial activity of ampicillin against Escherichia coli by combining it with myticaganal C. Antibacterial activity of ampicillin combined with myticaganal C against E. coli was assessed by agar well diffusion. Minimum inhibitory concentrations (MICs) and synergy by checkerboard assay of ampicillin and myticaganal C were assessed by resazurin-based 96-well microdilution. Bacterial responses were assessed by flow cytometry. Ampicillin in combination with myticaganal C showed better zone of inhibition (31.67 ± 0.58 mm) than myticaganal C or ampicillin alone. MIC of ampicillin was found to be 12.5 μg/mL, but myticaganal C was ineffective against E. coli. Myticaganal C (8000 μg/mL) with ampicillin (0.0975 μg/mL) exhibited strong synergy, so the need for ampicillin was reduced 128-fold. Combination inhibited E. coli by acting on cell membrane and by granularity disruptions. These findings indicate that myticaganal C enhances the potential of ampicillin against E. coli, thus providing an effective alternative to deal with the problem of bacterial resistance.
Characteristics of fatty acid composition and minor constituents of red palm olein and palm kernel oil combination
Authors: Nainggolan Marline , Sinaga Ahmad Gazali Sofwan
Published: January 2021

Red palm olein (RPOl) is one of the derivatives of palm oil. It contains a high composition of unsaturated fatty acids such as oleic and linoleic, whereas palm kernel oil (PKO) contains more saturated fatty acids of lauric acid. RPOl provides high nutrient contents such as squalene, Vitamin E, and carotene, whereas PKO that is rich in lauric acid can fight Gram-positive microorganisms. This research aims to study the chemical characteristics of RPOl, PKO, and the combination. A combination of RPOl with four different concentrations of PKO (20%, 50%, 80%, and 100%) was analyzed to obtain the composition of fatty acids, squalene content, Vitamin E levels, total carotene, and saponification numbers. RPOL contains high levels of squalene, Vitamin E, and total carotene, followed by RPOl and PKO combination of oil, with a higher percentage of RPOl in its composition. The increase of the PKO level added to the combination will decrease the saponification number and increasing the acid number. Therefore, it can be concluded that RPOl could be the source of squalene, Vitamin E, carotenoids, and oleic acid, whereas PKO is the largest source of lauric acid.
In vitro cytotoxic, genotoxic, and antityrosinase activities of Clitoria macrophylla root
Authors: Pitakpawasutthi Yamon , Suwatronnakorn Maneewan , Issaravanich Somchai , Palanuvej Chanida , Ruangrungsi Nijsiri
Published: January 2021

Clitoria macrophylla Wall. (Leguminosae), locally known as Non-tai-yak or An-chan-pa, commonly distributed in tropical nations and Southeast Asia. Regarding traditional Thai medical system, C. macrophylla roots carry out a potential in dermatology. Its roots are also used as insecticide in agriculture and animal farming. Moreover, clitoriacetal is the major component that can be detected in C. macrophylla root. This research aimed to assess the efficacy of C. macrophylla root extract and clitoriacetal for its anticancer and antityrosinase activities as well as to assess in vitro safety potential for its cytotoxic and genotoxic effects. C. macrophylla root and clitoriacetal were tested by brine shrimp lethality, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, comet assay, and antityrosinase activity. C. macrophylla root, clitoriacetal, and rotenone demonstrated the toxicity against brine shrimp nauplii with LC50 of 332.15, 136.54, and 0.15 μg/mL, respectively. C. macrophylla root and clitoriacetal showed cytotoxic potential against breast ductal carcinoma (BT-474), liver hepatoblastoma (Hep-G2), and colon adenocarcinoma (SW-620). At 100 μg/mL, the percent DNA damage of C. macrophylla root and clitoriacetal was 37.84% and 36.01%, respectively. C. macrophylla root and clitoriacetal were able to inhibit the tyrosinase enzyme with IC50 of 12.27 and 7.30 mg/mL, respectively, which less effective than glutathione (positive control). The present study revealed the in vitro biological activities of C. macrophylla root and its clitoriacetal constituent which proposed the scientific evidences in efficacy and safety evaluation including in vitro cytotoxicity, DNA damage as well as antityrosinase activities.