bluuebunny/crossref_metadata_2025 huggingface dataset:
La Liga de la Decencia: Performing 20th Century Mexican History in 21st Century Texas
Authors: Peña Torres Jessica
Published: February 2024

This article describes the development and public performances of La Liga de la Decencia, a new play presented as part of the 2023 New Works Festival at the University of Texas at Austin. Inspired by the cabaret scene and teatro de revista of the 1940s in Mexico City, La Liga de la Decencia combines live performance and video art to explore how hegemonic gender and social norms shaped by the emergent nationalism of postrevolutionary Mexico continue to oppress femme and queer bodies today across the US–Mexico border. Through satire, parody, and dance, La Liga de la Decencia problematizes the social, class, and gender norms as established by the cultural elite and the state. Following research-based theatre as an inquiry process, this article describes how writing and directing this play allowed for a deeper understanding of the dynamics of a historical period. By mixing facts, fiction, and critical commentary, La Liga de la Decencia investigates history through embodiment.
Development and Validation of a Chromatographic Method for Ibrutinib Determination in Human and Porcine Skin
Authors: Albuquerque Lucas F. F. , Souto Maria Victoria , Saldanha-Araujo Felipe , Carvalho Juliana Lott , Gratieri Tais , Cunha-Filho Marcilio , Gelfuso Guilherme M.
Published: February 2024

Ibrutinib (IBR) is a tyrosine kinase inhibitor investigated for treating solid and non-solid tumors. Considering the advantages that a topical application of IBR could generate in terms of dose reduction and side effects in skin cancer treatment, this paper presents a simple and selective HPLC method for determining IBR concentration in in vitro skin permeation studies to support the development of topical formulations. The method uses a reversed-phase C18 column and a mobile phase composed of acetonitrile and 0.01 mol/L phosphoric acid at pH 3.5 (35:65 v/v), flowing at 1.0 mL/min. The oven temperature was set at 35 °C, the injection volume was 20 μL, and UV drug detection was performed at 259 nm. The validation procedure certified that this method was selective for IBR determination even when extracted from human or porcine skin matrices. The method was linear over a range of 0.2 to 15.0 μg/mL, precise, robust, and accurate, with recovery rates from the skin layers higher than 89.5 ± 5.9% for the porcine skin and higher than 92.0 ± 0.2% for the human skin. The limits of detection and quantification were 0.01 and 0.02 μg/mL, respectively. The method showed, therefore, to be adequate for use in further skin permeation studies employing IBR topical formulations.
FPGA-Based Acceleration of K-Nearest Neighbor Algorithm on Fully Homomorphic Encrypted Data
Authors: Behera Sagarika , Prathuri Jhansi Rani
Published: February 2024

The suggested solution in this work makes use of the parallel processing capability of FPGA to enhance the efficiency of the K-Nearest Neighbor (KNN) algorithm on encrypted data. The suggested technique was assessed utilizing the breast cancer datasets and the findings indicate that the FPGA-based acceleration method provides significant performance improvements over software implementation. The Cheon–Kim–Kim–Song (CKKS) homomorphic encryption scheme is used for the computation of ciphertext. After extensive simulation in Python and implementation in FPGA, it was found that the proposed architecture brings down the computational time of KNN on ciphertext to a realistic value in the order of the KNN classification algorithm over plaintext. For the FPGA implementation, we used the Intel Agilex7 FPGA (AGFB014R24B2E2V) development board and validated the speed of computation, latency, throughput, and logic utilization. It was observed that the KNN on encrypted data has a computational time of 41.72 ms which is 80 times slower than the KNN on plaintext whose computational time is of 0.518 ms. The main computation time for CKKS FHE schemes is 41.72 ms. With our architecture, we were able to reduce the calculation time of the CKKS-based KNN to 0.85 ms by using 32 parallel encryption hardware and reaching 300 MHz speed.
Adapting an Adolescent and Young Adult Program Housed in a Quaternary Cancer Centre to a Regional Cancer Centre: Creating Equitable Access to Developmentally Tailored Support
Authors: Smith Marlie , Kurup Simone , Devaraja Kaviya , Shanawaz Shaayini , Reynolds Lorrie , Ross Jill , Bezjak Andrea , Gupta Abha A. , Kassam Alisha
Published: February 2024

Adolescents and young adults (AYAs) with cancer, representing those between 15 and 39 years of age, face distinctive challenges balancing their life stage with the physical, emotional, and social impacts of a cancer diagnosis. These challenges include fertility concerns, disruptions to educational and occupational pursuits, issues related to body image and sexual health, and the need for age-appropriate psychosocial support within their communities. The Princess Margaret Cancer Centre (PM), a quaternary care center, established a specialized AYA program in 2014, offering holistic and developmentally tailored psychosocial support and currently, efforts are underway to expand this to other regions in the province to address the need for equitable access. The establishment process involves securing funding, conducting an environmental scan, identifying service gaps, developing clinical pathways, and implementing AYA supportive care. An accessible AYA program should also consider social determinants of health, social location, intersectionality, and an interdisciplinary health approach in understanding health inequities in AYA oncology care. This paper describes the processes implemented and challenges faced in creating a community-based AYA program beyond major resource-rich cities and efforts to address intersectionality.
Hydromorphic Impact of Matera’s Urban Area
Authors: Ermini Ruggero , Fattore Carmen , Zoubi Amir Aubed
Published: February 2024

Urban transformations change land use, permeability, and morphology of the areas involved in the evolution process; this, consequently, modifies the impact produced by the precipitation phenomena and increases the risk of flooding or uncontrolled runoff in different areas.The proposed watershed hydrologic approach enables us to consider the morphology of the territory together with the transformations implemented by human activities, and this allows us to evaluate the effects of each area on neighboring areas, emphasizes the hydrological roles of upper, intermediate, and lower parts, and reveals urban and non-urban connections. This elucidates hydromorphic complexities in urban transformations and assesses climate change adaptability. The suggested methodology has been implemented in the urban district of “Sasso Caveoso” within the city of Matera. This application facilitates a quantitative synthesis of the contextual response, allowing for an analysis across various scenarios and offering decision-support tools of practical utility.
Inulin-Coated ZnO Nanoparticles: A Correlation between Preparation and Properties for Biostimulation Purposes
Authors: Gontrani Lorenzo , Bauer Elvira Maria , Casoli Lorenzo , Ricci Cosimo , Lembo Angelo , Donia Domenica Tommasa , Quaranta Simone , Carbone Marilena
Published: February 2024

Within the framework of plant biostimulation, a pivotal role is played by the achievement of low-cost, easily prepared nanoparticles for priming purposes. Therefore, in this report, two different synthetic strategies are described to engineer zinc oxide nanoparticles with an inulin coating. In both protocols, i.e., two-step and gel-like one-pot protocols, nanoparticles with a highly pure ZnO kernel are obtained when the reaction is carried out at T ≥ 40 °C, as ascertained by XRD and ATR/FTIR studies. However, a uniformly dispersed, highly homogeneous coating is achieved primarily when different temperatures, i.e., 60 °C and 40 °C, are employed in the two phases of the step-wise synthesis. In addition, a different binding mechanism, i.e., complexation, occurs in this case. When the gel-like process is employed, a high degree of coverage by the fructan is attained, leading to micrometric coated aggregates of nanometric particles, as revealed by SEM investigations. All NPs from the two-step synthesis feature electronic bandgaps in the 3.25–3.30 eV range in line with previous studies, whereas the extensive coating causes a remarkable 0.4 eV decrease in the bandgap. Overall, the global analysis of the investigations indicates that the samples synthesized at 60 °C and 40 °C are the best suited for biostimulation. Proof-of-principle assays upon Vicia faba seed priming with Zn5 and Zn5@inu indicated an effective growth stimulation of seedlings at doses of 100 mgKg−1, with concomitant Zn accumulation in the leaves.
Uncovering the Role of Hydroxycinnamoyl Transferase in Boosting Chlorogenic Acid Accumulation in Carthamus tinctorius Cells under Methyl Jasmonate Elicitation
Authors: Liu Zebo , Zhu Xiaofeng , Mohsin Ali , Sun Huijie , Du Linxiao , Yin Zhongping , Zhuang Yingping , Guo Meijin
Published: February 2024

Chlorogenic acids (CGAs) are bioactive compounds widely used in the food, pharmaceutical, and cosmetic industries. Carthamus tinctorius is an important economic crop, and its suspension cells are rich in CGAs. However, little is known about the biosynthesis and regulation of CGAs in Carthamus tinctorius cells. This study first elucidated the regulatory mechanism of CGA biosynthesis in methyl jasmonate (MeJA)-treated Carthamus tinctorius cells and the role of the MeJA-responsive hydroxycinnamoyl transferase (HCT) gene in enhancing their CGA accumulation. Firstly, temporal changes in intracellular metabolites showed that MeJA increased the intracellular CGA content up to 1.61-fold to 100.23 mg·g−1. Meanwhile, 31 primary metabolites showed significant differences, with 6 precursors related to increasing CGA biosynthesis. Secondly, the transcriptome data revealed 3637 new genes previously unannotated in the Carthamus tinctorius genome and 3653 differentially expressed genes. The genes involved in the plant signaling pathway and the biosynthesis of CGAs and their precursors showed a general up-regulation, especially the HCT gene family, which ultimately promoted CGA biosynthesis. Thirdly, the expression of a newly annotated and MeJA-responsive HCT gene (CtHCT, CtNewGene_3476) was demonstrated to be positively correlated with CGA accumulation in the cells, and transient overexpression of CtHCT enhanced CGA accumulation in tobacco. Finally, in vitro catalysis kinetics and molecular docking simulations revealed the ability and mechanism of the CtHCT protein to bind to various substrates and catalyze the formation of four hydroxycinnamic esters, including CGAs. These findings strengthened our understanding of the regulatory mechanism of CGA biosynthesis, thereby providing theoretical support for the efficient production of CGAs.
Special Issue: “New Trends in Diabetes, Hypertension, and Cardiovascular Diseases”
Authors: Wang Yutang , Magliano Dianna J.
Published: February 2024

Cardiovascular disease (CVD) encompasses a range of disorders affecting the heart and blood vessels, including coronary heart disease and cerebrovascular disease [...]
Dexamethasone Inhibits White Adipose Tissue Browning
Authors: Giordano Alejandra Paula , Gambaro Sabrina Eliana , Alzamendi Ana , Harnichar Alejandro Ezequiel , Rey María Amanda , Ongaro Luisina , Spinedi Eduardo , Zubiría María Guillermina , Giovambattista Andrés
Published: February 2024

White adipose tissue (WAT) regulates energy balance through energy storage, adipokines secretion and the thermogenesis process. Beige adipocytes are responsible for WAT thermogenesis. They are generated by adipogenesis or transdifferentiation during cold or β3-adrenergic agonist stimulus through a process called browning. Browning has gained significant interest for to its preventive effect on obesity. Glucocorticoids (GCs) have several functions in WAT biology; however, their role in beige adipocyte generation and WAT browning is not fully understood. The aim of our study was to determine the effect of dexamethasone (DXM) on WAT thermogenesis. For this purpose, rats were treated with DXM at room temperature (RT) or cold conditions to determine different thermogenic markers. Furthermore, the effects of DXM on the adipogenic potential of beige precursors and on mature beige adipocytes were evaluated in vitro. Our results showed that DXM decreased UCP-1 mRNA and protein levels, mainly after cold exposure. In vitro studies showed that DXM decreased the expression of a beige precursor marker (Ebf2), affecting their ability to differentiate into beige adipocytes, and inhibited the thermogenic response of mature beige adipocytes (Ucp-1, Dio2 and Pgc1α gene expressions and mitochondrial respiration). Overall, our data strongly suggest that DXM can inhibit the thermogenic program of both retroperitoneal and inguinal WAT depots, an effect that could be exerted, at least partially, by inhibiting de novo cell generation and the thermogenic response in beige adipocytes.
Special Issue “Molecular Advances in Cancer Genetics 3.0”
Authors: Bruno William , Ghiorzo Paola
Published: February 2024

The third volume of this Special Issue focuses on new advances in cancer genetics studies and collates papers reporting on a variety of mechanisms of tumorigenesis, the need to explore them from multiple perspectives, and the difficulties in exploring them, as well as the challenge of integrating them into a unifying but still different model for each tumor type [...]
miR-128-3p Regulates Follicular Granulosa Cell Proliferation and Apoptosis by Targeting the Growth Hormone Secretagogue Receptor
Authors: Dong Shucan , Jiang Shengwei , Hou Biwei , Li Yaokun , Sun Baoli , Guo Yongqing , Deng Ming , Liu Dewu , Liu Guangbin
Published: February 2024

The proliferation and apoptosis of granulosa cells (GCs) affect follicle development and reproductive disorders, with microRNAs playing a crucial regulatory role. Previous studies have shown the differential expression of miR-128-3p at different stages of goat follicle development, which suggests its potential regulatory role in follicle development. In this study, through the Cell Counting Kit-8 assay, the EDU assay, flow cytometry, quantitative real-time polymerase chain reaction, Western blot, and the dual-luciferase reporter assay, we used immortal human ovarian granulosa tumor cell line (KGN) cells as materials to investigate the effects of miR-128-3p and its predicted target gene growth hormone secretagogue receptor (GHSR) on GC proliferation and apoptosis. The results show that overexpression of miR-128-3p inhibited the proliferation of KGN cells, promoted cell apoptosis, and suppressed the expression of proliferating cell nuclear antigen (PCNA) and B-cell lymphoma-2 (BCL2) while promoting that of Bcl-2 associated X protein (BAX). The dual-luciferase reporter assay revealed that miR-128-3p bound to the 3′ untranslated region sequence of GHSR, which resulted in the inhibited expression of GHSR protein. Investigation of the effects of GHSR on GC proliferation and apoptosis revealed that GHSR overexpression promoted the expression of PCNA and BCL2, enhanced GC proliferation, and inhibited cell apoptosis, whereas the opposite effects were observed when GHSR expression was inhibited. In addition, miR-128-3p and GHSR can influence the expression of extracellular signal-regulated kinase 1/2 protein. In conclusion, miR-128-3p inhibits KGN cell proliferation and promotes cell apoptosis by downregulating the expression of the GHSR gene.
Adipose Tissue in Breast Cancer Microphysiological Models to Capture Human Diversity in Preclinical Models
Authors: Hamel Katie M. , Frazier Trivia P. , Williams Christopher , Duplessis Tamika , Rowan Brian G. , Gimble Jeffrey M. , Sanchez Cecilia G.
Published: February 2024

Female breast cancer accounts for 15.2% of all new cancer cases in the United States, with a continuing increase in incidence despite efforts to discover new targeted therapies. With an approximate failure rate of 85% for therapies in the early phases of clinical trials, there is a need for more translatable, new preclinical in vitro models that include cellular heterogeneity, extracellular matrix, and human-derived biomaterials. Specifically, adipose tissue and its resident cell populations have been identified as necessary attributes for current preclinical models. Adipose-derived stromal/stem cells (ASCs) and mature adipocytes are a normal part of the breast tissue composition and not only contribute to normal breast physiology but also play a significant role in breast cancer pathophysiology. Given the recognized pro-tumorigenic role of adipocytes in tumor progression, there remains a need to enhance the complexity of current models and account for the contribution of the components that exist within the adipose stromal environment to breast tumorigenesis. This review article captures the current landscape of preclinical breast cancer models with a focus on breast cancer microphysiological system (MPS) models and their counterpart patient-derived xenograft (PDX) models to capture patient diversity as they relate to adipose tissue.
Effects of Alterations in Acid–Base Effects on Insulin Signaling
Authors: Frassetto Lynda A. , Masharani Umesh
Published: February 2024

Insulin tightly regulates glucose levels within a narrow range through its action on muscle, adipose tissue and the liver. The activation of insulin receptors activates multiple intracellular pathways with different functions. Another tightly regulated complex system in the body is acid–base balance. Metabolic acidosis, defined as a blood pH < 7.35 and serum bicarbonate < 22 mmol/L, has clear pathophysiologic consequences including an effect on insulin action. With the ongoing intake of typical acid-producing Western diets and the age-related decline in renal function, there is an increase in acid levels within the range considered to be normal. This modest increase in acidosis is referred to as “acid stress” and it may have some pathophysiological consequences. In this article, we discuss the effects of acid stress on insulin actions in different tissues.
Placental and Renal Pathways Underlying Pre-Eclampsia
Authors: Andronikidi Paraskevi Eva , Orovou Eirini , Mavrigiannaki Eleftheria , Athanasiadou Virginia , Tzitiridou-Chatzopoulou Maria , Iatrakis George , Grapsa Eirini
Published: February 2024

Pre-eclampsia is a serious complication of pregnancy characterized by a state of multiorgan hypertensive disorders, with or without proteinuria and possible multiorgan dysfunction. Chronic kidney disease is an established risk factor for the development of pre-eclampsia, as angiogenic homeostasis is altered and the maternal circulation is already hypertensive. Facing pre-eclampsia in the context of chronic kidney disease is a challenging emergency for both the mother and the fetus. The clinical features and the management of this multi-organ disorder are clearly defined in the modern literature but the underlying pathophysiologic mechanisms remain not fully elucidated. Understanding the pathophysiology that mediates the onset of pre-eclampsia itself and in synergy with chronic kidney disease is fundamental for developing prompt prevention strategies, treatment planning, and patient counseling. This review aims to summarize the main molecular mechanisms involved in the process of pre-eclampsia, with a particular focus on the role of the kidneys and hormonal pathways related to renal function in normal pregnancy and pre-eclamptic syndromes.
The Killer’s Web: Interconnection between Inflammation, Epigenetics and Nutrition in Cancer
Authors: Mecca Marisabel , Picerno Simona , Cortellino Salvatore
Published: February 2024

Inflammation is a key contributor to both the initiation and progression of tumors, and it can be triggered by genetic instability within tumors, as well as by lifestyle and dietary factors. The inflammatory response plays a critical role in the genetic and epigenetic reprogramming of tumor cells, as well as in the cells that comprise the tumor microenvironment. Cells in the microenvironment acquire a phenotype that promotes immune evasion, progression, and metastasis. We will review the mechanisms and pathways involved in the interaction between tumors, inflammation, and nutrition, the limitations of current therapies, and discuss potential future therapeutic approaches.
Intrinsic Lipid Curvature and Bilayer Elasticity as Regulators of Channel Function: A Comparative Single-Molecule Study
Authors: Ashrafuzzaman Mohammad , Koeppe Roger E. , Andersen Olaf S.
Published: February 2024

Perturbations in bilayer material properties (thickness, lipid intrinsic curvature and elastic moduli) modulate the free energy difference between different membrane protein conformations, thereby leading to changes in the conformational preferences of bilayer-spanning proteins. To further explore the relative importance of curvature and elasticity in determining the changes in bilayer properties that underlie the modulation of channel function, we investigated how the micelle-forming amphiphiles Triton X-100, reduced Triton X-100 and the HII lipid phase promoter capsaicin modulate the function of alamethicin and gramicidin channels. Whether the amphiphile-induced changes in intrinsic curvature were negative or positive, amphiphile addition increased gramicidin channel appearance rates and lifetimes and stabilized the higher conductance states in alamethicin channels. When the intrinsic curvature was modulated by altering phospholipid head group interactions, however, maneuvers that promote a negative-going curvature stabilized the higher conductance states in alamethicin channels but destabilized gramicidin channels. Using gramicidin channels of different lengths to probe for changes in bilayer elasticity, we found that amphiphile adsorption increases bilayer elasticity, whereas altering head group interactions does not. We draw the following conclusions: first, confirming previous studies, both alamethicin and gramicidin channels are modulated by changes in lipid bilayer material properties, the changes occurring in parallel yet differing dependent on the property that is being changed; second, isolated, negative-going changes in curvature stabilize the higher current levels in alamethicin channels and destabilize gramicidin channels; third, increases in bilayer elasticity stabilize the higher current levels in alamethicin channels and stabilize gramicidin channels; and fourth, the energetic consequences of changes in elasticity tend to dominate over changes in curvature.
Deciphering the Interrelationship of arnT Involved in Lipid-A Alteration with the Virulence of Salmonella Typhimurium
Authors: Sivasankar Chandran , Lloren Khristine Kaith Sison , Lee John Hwa
Published: February 2024

The lipopolysaccharide (LPS) that resides on the outermost surface and protects Gram-negative bacteria from host defenses is one of the key components leading to Salmonella infection, particularly the endotoxic lipid A domain of LPS. Lipid A modifications have been associated with several genes such as the arnT that encodes 4-amino-4-deoxy-L-arabinose transferase, which can be critical for bacteria to resist cationic antimicrobial peptides and interfere with host immune recognition. However, the association of arnT with virulence is not completely understood. Thus, this study aimed to elucidate the interrelationship of the major lipid A modification gene arnT with Salmonella Typhimurium virulence. We observed that the arnT-deficient S. Typhimurium (JOL2943), compared to the wild type (JOL401), displayed a significant decrease in several virulence phenotypes such as polymyxin B resistance, intracellular survival, swarming, and biofilm and extracellular polymeric substance (EPS) production. Interestingly, the cell-surface hydrophobicity, adhesion, and invasion characteristics remained unaffected. Additionally, LPS isolated from the mutant induced notably lower levels of endotoxicity-related cytokines in RAW and Hela cells and mice, particularly IL-1β with a nine-fold decrease, than WT. In terms of in vivo colonization, JOL2943 showed diminished presence in internal organs such as the spleen and liver by more than 60%, while ileal infectivity remained similar to JOL401. Overall, the arnT deletion rendered the strain less virulent, with low endotoxicity, maintained gut infectivity, and reduced colonization in internal organs. With these ideal characteristics, it can be further explored as a potential attenuated Salmonella strain for therapeutics or vaccine delivery systems.
Changes in Phytohormones and Transcriptomic Reprogramming in Strawberry Leaves under Different Light Qualities
Authors: Li Peng , Wang Zhiqiang , Wang Xiaodi , Liu Fengzhi , Wang Haibo
Published: February 2024

Strawberry plants require light for growth, but the frequent occurrence of low-light weather in winter can lead to a decrease in the photosynthetic rate (Pn) of strawberry plants. Light-emitting diode (LED) systems could be used to increase Pn. However, the changes in the phytohormones and transcriptomic reprogramming in strawberry leaves under different light qualities are still unclear. In this study, we treated strawberry plants with sunlight, sunlight covered with a 50% sunshade net, no light, blue light (460 nm), red light (660 nm), and a 50% red/50% blue LED light combination for 3 days and 7 days. Our results revealed that the light quality has an effect on the contents of Chl a and Chl b, the minimal fluorescence (F0), and the Pn of strawberry plants. The light quality also affected the contents of abscisic acid (ABA), auxin (IAA), trans-zeatin-riboside (tZ), jasmonic acid (JA), and salicylic acid (SA). RNA sequencing (RNA-seq) revealed that differentially expressed genes (DEGs) are significantly enriched in photosynthesis antenna proteins, photosynthesis, carbon fixation in photosynthetic organisms, porphyrin and chlorophyll metabolisms, carotenoid biosynthesis, tryptophan metabolism, phenylalanine metabolism, zeatin biosynthesis, and linolenic acid metabolism. We then selected the key DEGs based on the results of a weighted gene co-expression network analysis (WGCNA) and drew nine metabolic heatmaps and protein–protein interaction networks to map light regulation.
Targeting ATR Pathway in Solid Tumors: Evidence of Improving Therapeutic Outcomes
Authors: Mavroeidi Dimitra , Georganta Anastasia , Panagiotou Emmanouil , Syrigos Konstantinos , Souliotis Vassilis L.
Published: February 2024

The DNA damage response (DDR) system is a complicated network of signaling pathways that detects and repairs DNA damage or induces apoptosis. Critical regulators of the DDR network include the DNA damage kinases ataxia telangiectasia mutated Rad3-related kinase (ATR) and ataxia-telangiectasia mutated (ATM). The ATR pathway coordinates processes such as replication stress response, stabilization of replication forks, cell cycle arrest, and DNA repair. ATR inhibition disrupts these functions, causing a reduction of DNA repair, accumulation of DNA damage, replication fork collapse, inappropriate mitotic entry, and mitotic catastrophe. Recent data have shown that the inhibition of ATR can lead to synthetic lethality in ATM-deficient malignancies. In addition, ATR inhibition plays a significant role in the activation of the immune system by increasing the tumor mutational burden and neoantigen load as well as by triggering the accumulation of cytosolic DNA and subsequently inducing the cGAS-STING pathway and the type I IFN response. Taken together, we review stimulating data showing that ATR kinase inhibition can alter the DDR network, the immune system, and their interplay and, therefore, potentially provide a novel strategy to improve the efficacy of antitumor therapy, using ATR inhibitors as monotherapy or in combination with genotoxic drugs and/or immunomodulators.
Dietary Intervention during Weaning and Development of Food Allergy: What Is the State of the Art?
Authors: Gravina Alessandro , Olivero Francesca , Brindisi Giulia , Comerci Antonia Fortunata , Ranucci Chiara , Fiorentini Cinzia , Sculco Eleonora , Figliozzi Ethel , Tudini Laura , Matys Viviana , De Canditiis Daniela , Piccioni Maria Grazia , Zicari Anna Maria , Anania Caterina
Published: February 2024

Food allergy (FA) affects approximately 6–8% of children worldwide causing a significant impact on the quality of life of children and their families. In past years, the possible role of weaning in the development of FA has been studied. According to recent studies, this is still controversial and influenced by several factors, such as the type of food, the age at food introduction and family history. In this narrative review, we aimed to collect the most recent evidence about weaning and its role in FA development, organizing the gathered data based on both the type of study and the food. As shown in most of the studies included in this review, early food introduction did not show a potential protective role against FA development, and we conclude that further evidence is needed from future clinical trials.
Monitoring Flow-Forming Processes Using Design of Experiments and a Machine Learning Approach Based on Randomized-Supervised Time Series Forest and Recursive Feature Elimination
Authors: Anozie Leroy , Fink Bodo , Friedrich Christoph M. , Engels Christoph
Published: February 2024

The machines of WF Maschinenbau process metal blanks into various workpieces using so-called flow-forming processes. The quality of these workpieces depends largely on the quality of the blanks and the condition of the machine. This creates an urgent need for automated monitoring of the forming processes and the condition of the machine. Since the complexity of the flow-forming processes makes physical modeling impossible, the present work deals with data-driven modeling using machine learning algorithms. The main contributions of this work lie in showcasing the feasibility of utilizing machine learning and sensor data to monitor flow-forming processes, along with developing a practical approach for this purpose. The approach includes an experimental design capable of providing the necessary data, as well as a procedure for preprocessing the data and extracting features that capture the information needed by the machine learning models to detect defects in the blank and the machine. To make efficient use of the small number of experiments available, the experimental design is generated using Design of Experiments methods. They consist of two parts. In the first part, a pre-selection of influencing variables relevant to the forming process is performed. In the second part of the design, the selected variables are investigated in more detail. The preprocessing procedure consists of feature engineering, feature extraction and feature selection. In the feature engineering step, the data set is augmented with time series variables that are meaningful in the domain. For feature extraction, an algorithm was developed based on the mechanisms of the r-STSF, a state-of-the-art algorithm for time series classification, extending them for multivariate time series and metric target variables. This feature extraction algorithm itself can be seen as an additional contribution of this work, because it is not tied to the application domain of monitoring flow-forming processes, but can be used as a feature extraction algorithm for multivariate time series classification in general. For feature selection, a Recursive Feature Elimination is employed. With the resulting features, random forests are trained to detect several quality features of the blank and defects of the machine. The trained models achieve good prediction accuracy for most of the target variables. This shows that the application of machine learning is a promising approach for the monitoring of flow-forming processes, which requires further investigation for confirmation.
Mechanism of Alleviating Acute Lung Injury in Mice from Serum Metabolomics Analysis of Cordyceps fumosorosea
Authors: Khan Tahir , Zhou Jinna , Guo Yingqi , Hou Donghai , Pi Na , Yang Yinlong , Yu Hong
Published: February 2024

Cordyceps fumosorosea is a common species within the Cordyceps genus. In this study, the protective effect of Cordyceps fumosorosea mycelium was investigated to clarify the potential mechanism of alleviating acute lung injury in mice using serum metabolomic analysis, which could provide a theoretical basis for the clinical application of C. fumosorosea. Sixty mice were divided into six groups (NS, LPS, MIX, COR, COC and DMX). Lung cell nuclei were analyzed using hematoxylin and eosin staining and cellular changes were observed using transmission electron microscopy (TEM). Metabolomic analyses using liquid chromatography-mass spectrometry (LC-MS) were used to identify various compounds. In all six groups, lung nuclear inflammation was observed in the COR, COC and DMX groups, whereas the NS, LPS and MIX groups showed no cellular changes, indicating good health. Metabolomic analysis using LC-MS identified 1607 compounds across various classes. Statistical analyses, including the coefficient of variation and OPLS-DA, revealed distinct metabolic proles, indicating significant changes after the consumption of C. fumosorosea mycelia. Lipids constituted the largest proportion (30.37%) of the 30 identified classes and subclasses of metabolites. A total of 617 differentially accumulated metabolites (DAMs) were identified, both unique and shared between comparisons. Metabolite analysis identified 617 differentially accumulated metabolites, with 493 common to the LPS vs. MIX group, 75 in the LPS vs. NS group and 49 in the LPS vs. NS group and LPS vs. MIX group. This comprehensive investigation suggests that C. fumosorosea mycelia treatment holds promise as a therapeutic intervention for lung injury, influencing both the histopathological (lung) features and serum metabolic profiles.
Biología pesquera de la gallineta, Prionotus stephanophrys (Lockington, 1880), procedentes de la flota polivalente durante el 2017 y 2018 en Ecuador
Authors: España Mindiolaza Sara , Revelo Ramírez Willan , Vergara Gabriela
Published: February 2024

La gallineta (Prionotus stephanophrys) es una de las especies más capturadas como parte de la fauna acompañante dentro de las faenas de pesca de la flota merlucera; por lo tanto, la presente investigación analizó la relación talla-peso, índice gonadosomático y talla media de madurez sexual de 622 individuos capturados incidentalmente por la flota polivalente en la costa ecuatoriana entre el 2017 y 2018, donde se observó que las tallas más frecuentes oscilaron entre 25 – 30 cm LT para ambos sexos, con una talla promedio para hembras de 27.73 ± 2.88 cm LT y para machos de 26.78 ± 2.51 cm LT; sin embargo, de manera general, no se encontraron diferencias significativas en la estructura de tallas en años combinados (p = > 0.05). Adicionalmente, la talla media de madurez sexual estimada fue de 20.22 cm de LT, por lo tanto, se considera que todos los individuos capturados incidentalmente se encuentran por encima de la madurez sexual, con únicamente el 3.86 % por debajo de esta.  La relación longitud total - peso total mostró para la especie un crecimiento alométrico negativo; mientras que, el índice gonadosomático estableció que la época reproductiva corresponde de marzo a noviembre y de abril a mayo como de reposo. La mayor captura incidental de individuos, sobre todo de hembras coincidió con la mayor intensidad reproductiva, con una proporción sexual de 1.5:1.
Aspek Hukum Implikasi Tantangan Globalisasi Terhadap Penyelenggaraan Pemerintahan Daerah Di Sumatera Utara
Authors: Sintara Dani , Bahri Samsul , Japatani Bonanda , Maryani Halimatul
Published: February 2024

Penelitian ini bertujuan untuk melakukan kajian terhadap pengaruh globalisasi pada pelaksanaan pemerintahan daerah  dan untuk menemukan kendala pemerintah daerah dalam era globalisasi. Metode penelitian ini menggunakan metode yuridis normatif dengan memanfaatkan data primer dan sekunder. Analisis data dilakukan secara kualitatif. Hasil penelitian yang pertama bahwa pengaruh globalisasi terhadap pemerintahan daerah telah memberikan warna atau corak pemerintahan yang otonom dengan mengikuti perkembangan jaman dan teknologi. Dalam kaitan ini, ditinjau dari asfek penyelenggaraan otonomi luas maka Pemerintahan Daerah beserta dengan masyarakatnya akan semakin memainkan peranan yang besar dalam membangun kemakmuran dan kesejahteraan sosial ekonomi masyarakat di daerah yang bersangkutan. Pemanfaatan teknologi dan informasi telah merubah struktur kebijakan pemerintah daerah yang berorientasi pada globalisasi. Kedua, di era globalisasi saat ini pemerintah daerah mengalami beberapa kendala diantaranya sumber daya manusia aparatur pemerintah daerah yang belum mampu bersaing secara global,  lemahnya kordinasi antara kepala daerah dengan Lembaga-lembaga daerah dalam pengambilan kebijakan yang bertentangan karkater dan budaya masyarakat daerah serta adanya ketidaksinkronan kebijakan pemerintah daerah dengan dengan Rancangan Anggaran Pendapatan Daerah yang berujung pada perbuatan korup pejabat daerah.
Kesiapan Elemen Support, Capacity Dan Value Untuk Pengembangan E-Government Pada Aplikasi “Miton” Bagian Administrasi Pembangunan Sekretariat Daerah Timor Tengah Utara Provinsi Nusa Tenggara Timur
Authors: Fahik Aryanto Klau , Akadira Tora , Jumiati Ipah Ema
Published: February 2024

This article aims to determine the extent of readiness for e-government development through the Online Integrated Information Management Application (Miton) in the Development Administration Section of the North Central Timor Regional Secretariat, East Nusa Tenggara Province. The problem focuses on 3 (three) important elements of e-Government Development, namely Support Elements, Capacity Elements, and Value Elements based on). To approach this problem, a theoretical reference from Indrajit, and an opinion from Indrajit (Indrajit 2016) was used. Data was collected through questionnaires and analyzed quantitatively. This study concluded that the average level of readiness of 3 (three) elements of successful e-government development in the Miton application it is 75.5% with the details of each element being as follows: (1) Support Elements are ready at 78.59%, (2) Capacity Elements are ready at 70.75%, (3) Value Elements are ready at 70.75% 77.14 %
Estratégias de apresentação de opinião em alunos de ensino básico e secundário: a abertura e a introdução
Authors: Marques Carla
Published: February 2024

O presente artigo propõe um estudo do texto de opinião oral e visa identificar algumas dimensões ensináveis deste género textual, no quadro do Interacionismo sociodiscursivo. Partindo da análise de um corpus de textos orais produzidos por alunos do 5.º, 7.º e 10.º ano, atentamos, particularmente, nas secções abertura e introdução, considerando ainda as subpartes que as integram, com vista a sinalizar as secções / subpartes consideradas pelos alunos. Pretende-se, deste modo, identificar os movimentos textuais não desenvolvidos e as características daqueles que são apresentados, o que permitirá clarificar os conteúdos que a escola deve trabalhar explicitamente com vista à promoção de abordagens didáticas que contemplem as várias dimensões da oralidade.
Referenciação em Arvorada: a (re)construção dos sentidos da tríade avó, neto e ipê-amarelo
Authors: Jesus Natalia Marques de , Bertolazzi Angélica Regina Gonçalves , Oliveira Lolyane Cristina Guerreiro de
Published: February 2024

Os estudos acerca da referenciação contemplam estratégias processuais, que auxiliam na progressão do texto e na (re)construção do sentido. Este artigo tem como objetivo principal observar, na história em quadrinhos Arvorada (2017) de Walmir Orlandeli, como a referenciação contribuiu para evidenciar a relevância da figura do idoso na construção identitária de uma criança. Os objetivos secundários abrangem: 1) demonstrar como as estratégias referenciais auxiliaram na formação do elo existente entre Chico Bento, sua avó Dita e o Ipê-amarelo; 2) elencar quais anáforas retomaram os referenciais introdutórios: um minino, uma anciã e um ipê-amarelo; e 3) verificar como a linguagem dos quadrinhos contribuiu para a construção da identidade de Chico Bento. Metodologicamente, apoia-se nas teorias relativas à referenciação (CAVALCANTI; SANTOS, 2012; CAVALCANTI, 2010; KOCH, 2003; 2012; 2014; 2016; 2018; MARCUSCHI, 2008); à identidade (BAUMAN, 2005; WOODWARD, 2012); e aos aspectos sociais sobre o idoso (WHITAKER, 2010;) e os benefícios de sua interação com as crianças (FRANÇA; SILVA; BARRETO, 2010; OLIVEIRA; VIANNA; CÁRDENAS, 2010). A análise, de cunho interpretativista, aponta que os elementos referenciais introdutórios e anafóricos evidenciam a conexão entre avó e neto, e consequentemente, a construção identitária parental.
From Portfolio to Platform Career
Authors: Clague Mark
Published: February 2024

Written as a concise guide for students and working professionals, this article examines and critiques the “portfolio career” in arts professional development to offer an alternative conceptual strategy to forge a sustainable life. Eight modes of arts work are explored (performing, teaching, creating, writing, healing, manufacturing, distributing, and administering). The “Platform Career” is proposed as an extension of and possible solution to the shortcomings of the portfolio career. In the platform model, one professional activity serves as a financial base for the artist’s panoply of creative work, providing health insurance and other employment benefits plus additional financial stability to reduce financial and emotional precarity.
Analisis Trend Metode Angka Indeks pada Laporan Laba Rugi PT Industri Jamu dan Farmasi Sido Muncul Tbk Periode 2019-2021
Authors: Santi Chitra , Mulyono Bella Juliany Putri , Felisia Anita
Published: February 2024

Meningkatnya pendapatan dari sektor industri barang konsumsi dengan sub-sektor farmasi di Indonesia pada era pandemi. Penelitian ini bertujuan untuk mengetahui peningkatan laba usaha dan tendensi pada laporan laba rugi PT Industri Jamu dan Farmasi Sido Muncul Tbk periode 2019 hingga 2021, yakni pra-pandemi hingga puncak pandemi. Metode penelitian yang digunakan bersifat studi kasus dengan data yang disajikan secara deskriptif kuantitatif. Hasil penelitian berupa kondisi laporan laba rugi 2019–2021 mengalami peningkatan laba usaha yang sangat signifikan, terutama pada periode 2020–2021 yang merupakan tahun puncak dari mewabahnya virus Covid–19, hal ini bisa terjadi dikarenakan minat masyarakat Indonesia terhadap obat – obatan berbasis herbal.
Democracia económica deficitaria en Centroamérica: caldo de cultivo para el autócrata de Naím
Authors: Andrei Cambronero Torres
Published: February 2024

El artículo expone cómo la democracia política debe acompañarse de una democracia económica, puesto que la pauperización de las condiciones de las personas puede ser caldo de cultivo para que se instalen los populismos, la polarización y la posverdad, como las tres “p” que identifican al autócrata de Naím.
Mangroves Addition as Innovation for Sustainable Tourism
Authors: Hillary Janne
Published: February 2024

Grand Maerokoco is a tourist site in Semarang, located close to Marina beach. The presence of mangroves in Maerokoco, is expected to protect it from the coastal disaster, as well as to make it as a new attraction. This study assessed the benefits of mangroves addition in Grand Maerokoco according to visitor perception, economic valuation toward mangrove plantation in there, and its ability to reduce noises. Visitor perception could be known by conducting interviews. Economic valuation measurement employed was TCM (Travel Cost Method). Then for determining the ability to reduce noises, a noise measurement using sound level meter was conducted. Based on visitor perception, existence of mangroves in Grand Maerokoco can increase the attraction, increase the number of visitors, make the air cooler and cleaner, reduce the noise, and prevent the entry of coastal floods. The existing noise known at some point of crowds is still below the threshold standards of the EPA (Environmental Protection Agency), caused by mangroves in Maerokoco are high and dense. The potential consumer surplus value per individual per visit is Rp717,792.00. The value indicates the visitors get the benefits of environmental services greater than the cost incurred. For increasing the values, utilizing mangroves for education and agribusiness functions, along with maintenance should be done.
Die Universität als Tätigkeitsfeld. Die Leitung von Portfoliogruppen im Rahmen des Berufsfeldpraktikums
Authors: Halkiew Daniel
Published: February 2024

Der Beitrag stellt ein Format des BFP innerhalb universitärer Lehr-Lernkonzepte der Lehrer:innenbildung an der Universität Münster vor, in dem die Studierenden ein Peer-Learning-Programm zum Praxisphasen-Portfolio durchlaufen, wodurch sie sich selber zu Begleiter:innen weiterer Studierender bei der methodisch fundierten reflexiven Auseinandersetzung mit Praxisphasen mit Hilfe eines Portfolios qualifizieren. (DIPF/Orig.)
Berufsfeldpraktikum Welcome to School im Fachbereich Deutsch als Zweit-/Fremdsprache. Berufsbezogene Selbstkonzepte und Berufswahlsicherheit im BFP an der Universität Duisburg-Essen (UDE) entwickeln
Authors: Lorth Nicole , Reuschenbach Ursula
Published: February 2024

Der Beitrag stellt das an der Universität Duisburg-Essen angesiedelte Projekt Welcome to School vor, das in Kooperation des Zentrums für Lehrkräftebildung mit dem Projekt Deutsch als Zweitsprache in allen Fächern (ProDaZ) durchgeführt wird. Eine Qualifizierung der Studierenden für den sprachsensiblen Unterricht sowie für Aspekte von Interkulturalität ist die Zielstellung dieses Konzepts. (DIPF/Orig.)
Das DaZ-spezifische Praktikumsformat der Universität Bielefeld. FörBi – Förderunterricht für Schülerinnen und Schüler nicht deutscher Herkunftssprachen
Authors: Hinrichs Beatrix , Wahbe Nadia , Kahmen Frederik , Riemer Claudia
Published: February 2024

Die Autor*innen stellen das Projekt FörBi – Förderunterricht für Schülerinnen und Schüler nicht deutscher Herkunftssprachen – an der Universität Bielefeld vor. Lehramtsstudierende der Germanistik und der Anglistik können in diesem Projekt ihr BFP absolvieren. Ziel des Projekts ist es, dass Studierende bereits im Studium erste Einsichten und praktische Lehrerfahrungen im Bereich von unterrichtsbzw. fachintegrierter DaZ-Förderung und DaZ-Diagnostik gewinnen. (DIPF/Orig.)
Auf dem Weg zur Professionalisierung. Multiperspektivische Zugänge zur Umsetzung sprachbildender Projekte in schulischen und außerschulischen Kontexten
Authors: Beese Melanie , Heil Rebekka , Jahn Stefanie , Moraitis Anastasia , Salewski-Teßmann Kerstin , Schubert Julia
Published: February 2024

Der Beitrag beschäftigt sich mit dem Angebot verschiedener Formate zur sprachsensiblen Unterstützung und Förderung von Schüler:innen mit Deutsch als Zweitsprache und insbesondere von neu zugewanderten Kindern unter Berücksichtigung individueller Voraussetzungen und Bedarfe an der Universität Duisburg-Essen. (DIPF/Orig.)
Bochumer Berufsfeldpraktika. Einblicke in Bildungsübergänge von der Primarstufe in die Sekundarstufe und in die Berufliche Bildung
Authors: Kull Carolin , Mattiesson Christiane
Published: February 2024

Im Beitrag werden zwei Formate des BFP der Professional School of Education der Ruhr-Universität Bochum vorgestellt, die Bildungsübergänge in den Mittelpunkt stellen: das BFP ready4takeoff (Übergang Grundschule – weiterführende Schule) und das BFP Lehr- und Lernprozesse in der Berufsausbildung (Schritt von der weiterführenden Schule in die Berufsausbildung). (DIPF/Orig.)
International und digital – im Berufsfeldpraktikum neue Welten erschließen
Authors: Diehr Bärbel , Fischer Anna Elisabeth
Published: February 2024

Der Beitrag stellt ein BFP-Konzept für Internationalisation at home an der Bergischen Universität Wuppertal vor. Nachdem die Corona-Pandemie Auslandspraktika zum Erliegen brachte, wurde in der Fachdidaktik Englisch ein digitales BFP entwickelt, das Studierenden virtuelle Auslandserfahrungen und deren Reflexion ermöglicht. (DIPF/Orig.)