bluuebunny/crossref_metadata_2025 huggingface dataset:
NGHIÊN CỨU THỰC TRẠNG QUẢN LÝ CHẤT THẢI RẮN Y TẾ TẠI BỆNH VIỆN ĐA KHOA TỈNH CAO BẰNG NĂM 2021
Authors: Văn Bằng Nguyễn , Văn Huỳnh Vũ , Thị Phương Liên Đinh , Thị Chuyền Nông , Thị Thu Thủy Trần
Published: April 2022

Mục tiêu: đánh giá  thực trạng quản lý chất thải rắn y tế tại Bệnh viện Đa khoa tỉnh Cao Bằng năm 2021. Đối tượng và phương pháp nghiên cứu: Dụng cụ, phương tiện phân loại, thu gom tại 23 khoa lâm sàng và 5 khoa cận lâm sàng, phương tiện vận chuyển, khu vực lưu giữ, khu vực xử lý CTRYT. Nhân viên y tế/ người lao động trực tiếp tham gia vào hoạt động phân loại, thu gom, vận chuyển, lưu giữ và xử lý CTRYT; nghiên cứu: 23 khoa lâm sàng, 5 khoa cận lâm sàng Bệnh viện Đa khoa tỉnh Cao Bằng; thiết kế nghiên cứu cắt ngang kết hợp phương pháp định lượng và định tính. Kết quả: dụng cụ phục vụ phân loại, thu gom CTRYT tương đối đầy đủ và đạt chuẩn, từ túi đựng đến thùng đựng từng loại chất thải khác nhau với quy định về an toàn (92,9% - 100%), dụng cụ thu gom được bệnh việu trang bị đầy đủ đáp ứng gần như 100% theo nhu cầu của khoa, trang thiết bị, cơ sở vật chất phục vụ lưu giữ và xử lý CTRYT của bệnh viện được trang bị khá đầy đủ; tỷ lệ NVYT thực hiện phân loại đúng với các loại chất thải lây nhiễm, chất thải sắc nhọn, chất thải lây nhiễm sắc nhọn phân loại đúng (86,6% -100%); các loại chất thải thông thường tái chế và không tái chế được, tỷ lệ phân loại đúng vào loại túi đựng có màu phù hợp (50,0% - 79,1%) tùy vị trí vệc làm. Kết luận: 92,9% - 100% các khoa được trang bị đủ trang thiết bị, dụng cụ phục vụ phân loại, thu gom, vận chuyển CTRYT, 4/28 khoa có đủ thùng thu gom chất thải có các màu sắc theo quy định; khu vực lưu giữ và xử lý được trang bị đầy đủ trang thiết bị; tỷ lệ thực hành phân loại chất thải của nhân viên y tế bệnh viện: 57,4%; các khâu thu gom, vận chuyển, lưu giữ và xử lý đạt yêu cầu.
IMPACT OF BANKING SECTOR CREDITS ON NET SME FORMATION IN TURKEY
Authors: ALICIOĞLU Yasemin , KÜÇÜKKOCAOĞLU Güray
Published: April 2022

Purpose: This study examines the impact of banking sector credit on the growth of small and medium enterprises in Turkey. The main objective of the study is to investigate whether state-equity bank group or private-equity bank group credits have significant impact on the growth of net Small and Medium Enterprise (SME) formation a regional, urban and sectoral basis.
Methodology: As part of the methodology, quarterly data between 2010-2019 was collected and used in the study for Panel Cointegration Model.
Findings: The formulated hypotheses reveal that private-equity bank credits have significant impact on the growth of small and medium enterprises in Turkey. For statistical region segmentation, city segmentation and sectoral segmentation, private equity bank group credit coefficient is higher than state equity bank group. LPCT (private equity bank group city based logarithmic total credits) variable has a higher coefficient than LSCT (state equity bank group city based logarithmic total credits) variable.
Originality: During literature review, no work with these variables could be found. This work is expected to fill a gap in the literature.
Laboratory characterisation and intercomparison sounding test of dual thermistor radiosondes for radiation correction
Authors: Lee Sang-Wook , Kim Sunghun , Lee Young-Suk , Yoo Jae-Keun , Lee Sungjun , Kwon Suyong , Choi Byung Il , So Jaewon , Kim Yong-Gyoo
Published: April 2022

Abstract. A dual thermistor radiosonde (DTR) comprising two
(aluminium-coated and black) sensors with different emissivities was
developed to correct the effects of solar radiation on temperature probes
based on in situ radiation measurements. Herein, the DTR performance is
characterised in terms of the uncertainty via a series of ground-based
facilities and an intercomparison radiosounding test. The DTR
characterisation procedure using laboratory facilities is as follows:
individually calibrate the temperature of the thermistors in a climate
chamber from −70 to 30 ∘C to evaluate the uncertainty of raw
temperature measurement before radiation correction; test the effect of
temperature on the resistance reading using radiosonde boards in the climate
chamber from −70 to 20 ∘C to identify a potential source of errors
owing to the boards, especially at cold temperatures; individually perform
radiation tests on thermistors at room temperature to investigate the degree of heating of aluminium-coated and black sensors (the average ratio = 1 : 2.4) and use the result for obtaining unit-specific radiation correction
formulas; and perform parameterisation of the radiation measurement and
correction formulas with five representative pairs of sensors in terms of
temperature, pressure, ventilation speed, and irradiance using an upper air
simulator. These results are combined and applied to the DTR sounding test
conducted in July 2021. Thereafter, the effective irradiance is measured
using the temperature difference between the aluminium-coated and black
sensors of the DTR. The measured irradiance is then used for the radiation
correction of the DTR aluminium-coated sensor. The radiation-corrected
temperature of the DTR is mostly consistent with that of a commercial
radiosonde (Vaisala, RS41) within the expanded uncertainty
(∼ 0.35 ∘C) of the DTR at the coverage factor k = 2. Furthermore, the
components contributing to the uncertainty of the radiation measurement and
correction are analysed. The DTR methodology can improve the accuracy of
temperature measurement in the upper air within the framework of the
traceability to the International System of Units.
Large ensemble of downscaled historical daily snowfall from an earth system model to 5.5 km resolution over Dronning Maud Land, Antarctica
Authors: Ghilain Nicolas , Vannitsem Stéphane , Dalaiden Quentin , Goosse Hugues , De Cruz Lesley , Wei Wenguang
Published: April 2022

Abstract. We explore a methodology to statistically downscale snowfall – the primary driver of surface mass
balance in Antarctica – from an ensemble of historical (1850–present day) simulations performed
with an earth system model over the coastal region of Dronning Maud Land (East Antarctica).
This approach consists of associating daily snowfall simulations from a polar-oriented regional
atmospheric climate model at 5.5 km spatial resolution with specific weather patterns observed
over 1979–2010 CE with the atmospheric reanalyses ERA-Interim and ERA5. This association is
then used to generate the spatial distribution of snowfall for the period from 1850 to present day for
an ensemble of 10 members from the Community Earth System Model (CESM2). The new dataset of daily and
yearly snowfall accumulation based on this methodology is presented in this paper (MASS2ANT
dataset; https://doi.org/10.5281/zenodo.4287517; Ghilain et al., 2021). Based on a comparison
with available ice cores and spatial reconstructions, our results show that the spatio-temporal
distribution of snowfall is improved in the downscaled dataset compared with the CESM2
simulations. This dataset thus provides information that may be useful in identifying the large-scale
patterns associated with the local precipitation conditions and their changes over the past century.
I. ESTUDIOS
Authors: Arredondo Erika
Published: April 2022

N/A
Sierra Nevada (Spain), the southernmost European locality for the polar-alpine Umbilicaria aprina and U. virginis.
Authors: García Sancho Leopoldo , Aramburu Ana , Pintado Ana , Casares Manuel , Raggio José , Sánchez-Pescador David
Published: April 2022

Two strict polar-alpine Umbilicaria species (U. aprina and U. virginis) are reported growing together in Los Peñones de San Francisco. Other localities known on the highest summits of the Alps and Pyrenees are considered. We discussed the meaning of these isolated populations as glacial relicts.
Types of documents, productions and activities promoted by open science and eligible for evaluation
Authors:   Collège Publications,   Groupe Projet Evaluation
Published: April 2022

The implementation of open science requires all research processes and activities to be taken into account in evaluation. To this end, the document lists the types of documents and productions developed within the entire research cycle and their modes of open dissemination as well as the types of activities eligible for evaluation.
Des identifiants ouverts pour la science ouverte
Authors:   Collège Europe Et International
Published: April 2022

Le document définit dans un premier chapitre ce que sont les identifiants et les registres, leur rôle et leur importance, les attentes en matière de science ouverte. Dans un second chapitre, le comité pour la science ouverte expose son programme d’actions à l’échelle nationale pour les identifiants des publications scientifiques et des données de la recherche.
COUNTERING TERRORISM AND REDUCING STRATEGIC UNCERTAINTY: ANALYSING ‘SHAPING’ MULTINATIONAL MILITARY EXERCISES
Authors: Bashir Sadaf , Gul Sumara
Published: April 2022

The post-Cold War period has witnessed a significant increase in ‘shaping’ multinational military exercises, which are considered a valuable instrument of defence diplomacy. Shaping multinational military exercises aim to encourage the partner military's role and adapt relationship to reduce strategic uncertainty. Since 2014, Pakistan’s conduct and participation in multinational military exercises have increased significantly. Pakistan conducts four such exercises to reduce strategic uncertainty: recruitment, capacity-building, role-forming, and trust-developing. This article, therefore, argues that Pakistan pursues shaping multinational military exercises to mould the strategic thinking of both friends and potential adversaries to achieve foreign policy goals in a complex security environment.
 
Bibliography Entry
Bashir, Sadaf, Sumara Gul. 2021. "Countering Terrorism and Reducing Strategic Uncertainty: Analysing ‘Shaping’ Multinational Military Exercises." Margalla Papers 25 (2): 71-83.
Variants and/in/of the Rhetoric of Health and Medicine
Authors: Molloy Cathryn , Hensley Owens Kim
Published: April 2022

Editors' introduction to 5.1
Productive Tensions
Authors: Bingham Christopher B. , McDonald Rory M.
Published: April 2022

How leaders can recast innovation's toughest trade-offs—efficiency vs. flexibility, consistency vs. change, product vs purpose—as productive tensions.

Why is leading innovation in today's dynamic business environment so distressingly hit-or-miss? More than 90 percent of high-potential ventures don't reach their projected targets. Surveys show that 80 percent of executives consider innovation crucial to their growth strategy, but only 6 percent are satisfied with their innovation performance. Should leaders aim for Steve Jobs-level genius, shower their projects with resources, or lean in to luck and embrace uncertainty? None of the above, say Christopher Bingham and Rory McDonald.

Drawing on cutting-edge research and probing interviews with hundreds of leaders across three continents, Bingham and McDonald find in Productive Tensions that the most effective leaders and successful innovators embrace the tensions that arise from competing aims: efficiency or flexibility? consistency or change? product or purpose? Bingham and McDonald spotlight eight critical tensions that every innovator must master, and they spell out, with dozens of detailed examples of both success and failure, how to navigate them. How do you excite customers about a product they've never imagined? When is it wise to accept what the data is telling you, and when should you ignore the data and plow forward anyway? How can you maintain stakeholders' trust and support during radical unforeseen course corrections? Bingham and McDonald guide readers through innovation's thorniest tensions, using examples drawn from the experience of organizations as varied as P&G, Instagram, the US military, Honda, In-N-Out Burger, Slack, Under Armour, and the snowboarding company Burton.
Radar remote sensing-based inversion model of soil salt content at different depths under vegetation
Authors: Chen Yinwen , Du Yuyan , Yin Haoyuan , Wang Huiyun , Chen Haiying , Li Xianwen , Zhang Zhitao , Chen Junying
Published: April 2022

Excessive soil salt content (SSC) seriously affects the crop growth and economic benefits in the agricultural production area. Prior research mainly focused on estimating the salinity in the top bare soil rather than in deep soil that is vital to crop growth. For this end, an experiment was carried out in the Hetao Irrigation District, Inner Mongolia, China. In the experiment, the SSC at different depths under vegetation was measured, and the Sentinel-1 radar images were obtained synchronously. The radar backscattering coefficients (VV and VH) were combined to construct multiple indices, whose sensitivity was then analyzed using the best subset selection (BSS). Meanwhile, four most commonly used algorithms, partial least squares regression (PLSR), quantile regression (QR), support vector machine (SVM), and extreme learning machine (ELM), were utilized to construct estimation models of salinity at the depths of 0–10, 10–20, 0–20, 20–40, 0–40, 40–60 and 0–60 cm before and after BSS, respectively. The results showed: (a) radar remote sensing can be used to estimate the salinity in the root zone of vegetation (0-30 cm); (b) after BSS, the correlation coefficients and estimation accuracy of the four monitoring models were all improved significantly; (c) the estimation accuracy of the four regression models was: SVM > QR > ELM > PLSR; and (d) among the seven sampling depths, 10–20 cm was the optimal inversion depth for all the four models, followed by 20–40 and 0–40 cm. Among the four models, SVM was higher in accuracy than the other three at 10–20 cm (RP2 = 0.67, RMSEP = 0.12%). These findings can provide valuable guidance for soil salinity monitoring and agricultural production in the arid or semi-arid areas under vegetation.
Cytotoxicity of Different Ages of Weed Debris Extract of Ageratum conyzoides (Billy Goat Weed) using Allium cepa L. Assay
Authors: V Adeleke, Martina T. , Bright Onyegorom,
Published: April 2022

Considering the present inhibition of seed germination, reduction in agricultural yields and the unexpected death of plants in the field, an experiment was conducted to evaluate the cytotoxicity of weed debris extract from soaked plants of Ageratum conyzoides (Billy goat weed) on plants using the Allium cepa L. assay. The onion bulbs were first placed in water for 48 hours to initiate root growth, then they were placed in the weed extract got from different soaking periods of all the plant parts of A. conyzoides (which served as the treatments) for 24 hours. Both macroscopic and microscopic parameters show the toxic effect of A. conyzoides. Root length and root number dropped in value with lower soaking period of A. conyzoides. The cells of the 36hrs treatment were charred; those of the 72hrs were not charred, but had their nuclei fallen out of the cells because the cell wall had broken open; while the cells of the 120hrs treatment had intact cells, but with no sign of division. Hence the mitotic index of the treatments could not be ascertained. It was however observed that treatment effect on the cells decreased with increase in soaking period of the weed. This proves that A. conyzoides is allelopathic in nature, and time is required to get rid of its harmful allelochemicals for this weed debris to be useful in enriching the soil.
Perceptions of Sustainable Utilization of Coastal Resources in the Pangandaran Sub-District
Authors: Firdaus Feriany Athala , Rizal Achmad , Mulyani Yuniar , Suryana Asep Agus Handaka
Published: April 2022

This study aims to determine the Community's perception of the sustainability of resource use in Pangandaran District, Pangandaran Regency, West Java, 2022. The method used in this research is a survey method. The sampling technique used Accidental Sampling with a total of 50 respondents. Data collection use questionnaires and documentation techniques. Then the data was processed use the chi square method. The results showed that the sustainability of coastal resources in the Pangandaran District was classified as moderate, with a percentage of 48%. The factors that support the sustainable use of coastal resources include economic factors that have a calculated chi-square value of 15,089. Then, social factors have a calculated chi-square value that is 18, 163. Environmental factors also have a significant influence, namely by value. The calculated chi-square value obtained is 16,322 . These tree factor have degrees of freedom (df) = 6 where the chi-square tabel is 12,592. So as for decision making in the research method, it can be said that H0 is rejected and Ha is accepted which means that there is a relationship between coastal resources and economic, social and environmental factors. Other factors that affect sustainability are government policy information obtained by the Community and community understanding of the sustainable use of coastal resources. The results of the sustainable use of coastal resources will be correlated with applicable government regulations including related factors.
Metabolism and autophagy in plants—a perfect match
Authors: Magen Sahar , Seybold Heike , Laloum Daniel , Avin‐Wittenberg Tamar
Published: April 2022

Autophagy is a eukaryotic cellular transport mechanism that delivers intracellular macromolecules, proteins, and even organelles to a lytic organelle (vacuole in yeast and plants/lysosome in animals) for degradation and nutrient recycling. The process is mediated by highly conserved autophagy‐related (ATG) proteins. In plants, autophagy maintains cellular homeostasis under favorable conditions, guaranteeing normal plant growth and fitness. Severe stress such as nutrient starvation and plant senescence further induce it, thus ensuring plant survival under unfavorable conditions by providing nutrients through the removal of damaged or aged proteins, or organelles. In this article, we examine the interplay between metabolism and autophagy, focusing on the different aspects of this reciprocal relationship. We show that autophagy has a strong influence on a range of metabolic processes, whereas at the same time, even single metabolites can activate autophagy. We highlight the involvement of ATG genes in metabolism, examine the role of the macronutrients carbon and nitrogen, and various micronutrients, and take a closer look at how the interaction between autophagy and metabolism impacts on plant phenotypes and yield.
Doping‐Induced Electronic/Ionic Engineering to Optimize the Redox Kinetics for Potassium Storage: A Case Study of Ni‐Doped CoSe2
Authors: Shan Hui , Qin Jian , Wang Jingjing , Sari Hirbod Maleki Kheimeh , Lei Li , Xiao Wei , Li Wenbin , Xie Chong , Yang Huijuan , Luo Yangyang , Zhang Gaini , Li Xifei
Published: April 2022

Heteroatom doping effectively tunes the electronic conductivity of transition metal selenides (TMSs) with rapid K+ accessibility in potassium ion batteries (PIBs). Although considerable efforts are dedicated to investigating the relationship between the doping strategy and the resulting electrochemistry, the doping mechanisms, especially in view of the ion and electronic diffusion kinetics upon cycling, are seldom elucidated systematically. Herein, the crystal structure stability, charge/ion state, and bandgap of the active materials are found to be precisely modulated by favorable heteroatom doping, resulting in intrinsically fast kinetics of the electrode materials. Based on the combined mechanisms of intercalation and conversion reactions, electron and K+ ion transfer in Ni‐doped CoSe2 embedded in carbon nanocomposites (Ni‐CoSe2@NC) can be significantly enhanced via electronic engineering. Benefiting from the synthetic controlled Ni grains, the heterointerface formed by the intermediate products of electrochemical reactions in Ni‐CoSe2@NC strengthens the conversion kinetics and interdiffusion process, developing a low‐barrier mesophase with optimized potassium storage. Overall, an electronic tuning strategy can offer deeper atomic insights into the conversion reaction of TMSs in PIBs.
Synthesis of Defective Nanographenes Containing Joined Pentagons and Heptagons
Authors: Fei Yiyang , Liu Junzhi
Published: April 2022

Defective nanographenes containing joined pentagons and heptagons exhibit striking physicochemical properties from both experimental and theoretical perspectives compared with their pure hexagonal counterparts. Thus, the synthesis and characterization of these unique polyarenes with well‐defined defective topologies have attracted increasing attention. Despite extensive research on nonalternant molecules since the last century, most studies focused on the corresponding mutagenic and carcinogenic activities. Recently, researchers have realized that the defective domain induces geometric bending and causes electronic perturbation, thus leading to significant alteration of the photophysical properties. This review discusses the synthesis and characterization of small nonalternant polycyclic hydrocarbons in the early stage and recent developments in embedding pentagon–heptagon (5–7) pairs into large carbon skeletons through in‐solution chemistry.
Temperature and Rainfall Patterns Constrain the Multidimensional Rewilding of Global Forests
Authors: Zhou Guiyao , Zhou Xuhui , Eldridge David J. , Han Ximei , Song Yanjun , Liu Ruiqiang , Zhou Lingyan , He Yanghui , Du Zhenggang , Delgado‐Baquerizo Manuel
Published: April 2022

The long‐term contribution of global forest restoration to support multiple dimensions of biodiversity and ecosystem function remains largely illusive across contrasting climates and forest types. This hampers the capacity to predict the future of forest rewilding under changing global climates. Here, 120 studies are synthesized across five continents, and it is found that forest restoration promotes multiple dimensions of biodiversity and ecosystem function such as soil fertility, plant biomass, microbial habitat, and carbon sequestration across contrasting climates and forest types. Based on global relationship between stand age and soil organic carbon stock, planting 350 million hectares of forest under the UN Bonn Challenge can sequester >30 Gt soil C in the surface 20 cm over the next century. However, these findings also indicate that predicted increases in temperature and reductions in precipitation can constrain the positive effects of forest rewilding on biodiversity and ecosystem function. Further, important tradeoffs are found in very old forests, with considerable disconnection between biodiversity and ecosystem function. Together, these findings provide evidence of the importance of the multidimensional rewilding of forests, suggesting that on‐going climatic changes may dampen the expectations of the positive effects of forest restoration on biodiversity and ecosystem function.
Concise access to perimidines by palladium (II) complexes via acceptorless dehydrogenative coupling of alcohols
Authors: Clinton Savarimuthu Selvan , Ramesh Rengan , Małecki Jan Grzegorz
Published: April 2022

A facile protocol for the one‐pot synthesis of 2,3‐dihydro‐1H‐perimidines via dehydrogenative coupling of easily exploitable benzyl alcohols supported by new Pd(II) complexes has been reported. To accomplish the construction of perimidines, a new set of palladium(II) complexes [Pd(L)Cl (PPh3)] (1–3) encompassing biphenyl benzhydrazone ligands (L=L1–L3) has been reported as catalysts. Structural characterization by elemental analysis, FT‐IR, NMR (1H and13C), and mass spectral analyses confirmed the composition of synthesized complexes. The molecular structures complex1and complex2were unequivocally resolved using single‐crystal X‐ray diffraction. It reveals that the complex espoused distorted square‐planar geometry around Pd(II) ion chelated by azomethine nitrogen and imidolate oxygen of biphenyl benzhydrazone ligands with labile chloride and a triphenylphosphine. Further, the selective synthesis of a broad range of functionalized perimidines has been accomplished via ADC of a variety of alcohols with 1,8‐diamino naphthalene. The palladium complexes mediated catalytic synthesis offered good yields of perimidines up to 86% using only 0.5 mol% catalyst loading. A probable mechanism to the formation of perimidines was postulated from the results of control experimental investigations. The environmentally compassionate, greener ADC protocol progresses via the generation of aldehyde intermediate and releases only water and hydrogen gas.
Efficient Oxidation of Paracetamol Triggered by Molecular‐Oxygen Activation at β‐Cyclodextrin‐Modified Titanate Nanotubes
Authors: Zhou Yi , Liu Qiming , Li Xia , Ling Liangxiong , Zhou Yanbo
Published: April 2022

Titanate nanotubes (TNTs) were coated with a cyclic oligosaccharide (carboxymethyl‐β‐cyclodextrin, CM‐β‐CD) to obtain a photocatalyst (CM‐β‐CD‐TNT) for efficiently activating molecular oxygen and removing the target contaminant. The hydrophobic cavity and the large specific surface area of the photocatalyst provide abundant active sites for activating molecular oxygen. The free radical capture experiment and quenching experiment showed that cyclodextrin could facilitate adsorption and activation of molecular oxygen to produce O2.−. Therefore, compared with the pristine TNT, CM‐β‐CD‐TNT accelerated the oxidation efficiency of paracetamol (APAP) by 3.4 times. Moreover, the ring cleavage reaction induced by CM‐β‐CD‐TNT effectively reduced the acute toxicity of wastewater containing APAP. Furthermore, 100% of bisphenol A (BPA), bisphenol S (BPS), phenol, 2,4‐dichlorophen (2,4‐DCP), and carbamazepine (CBZ) were degraded by CM‐β‐CD‐TNT after 2.5 h ultraviolet (UV) light irradiation. This strategy provides a new dimension for the advanced treatment of organic wastewater by organic macrocyclic molecule‐modified materials.
Non‐fragile reliable control of nonlinear positive semi‐Markovian jump systems with nonlinear actuator faults
Authors: Liu Jinjin , Song Chunyue , Li Zhiqiang , Zhang Ting
Published: April 2022

This paper investigates the non‐fragile reliable control of nonlinear positive semi‐Markovian jump systems with nonlinear actuator faults. First, a novel fault model consisting of linear and nonlinear terms is established for the systems. By constructing a stochastic co‐positive Lyapunov function, the non‐fragile reliable controller is designed for the systems with additive gain perturbations using matrix decomposition technique. Then, the proposed design is extended for dealing with multiplicative gain perturbations and variable gain perturbations. Under the designed controllers, the resulting closed‐loop systems are positive and stochastically stable. All presented conditions are solvable in terms of linear programming. Finally, two illustrative examples are provided to verify the effectiveness of the theoretical results.
How bricolage influences green management in high‐polluting manufacturing firms: The role of stakeholder engagement
Authors: Wu Liang , Liu Heng
Published: April 2022

As green management (GM) matters not only for firms' competitiveness but also has social and health benefits, both the public and government often expect firms to apply it. However, the current literature fails to provide a detailed explanation of how emerging market firms in high‐polluting manufacturing (HPM) industries deal with challenges when applying GM activities, even though these firms may be a key source of environmental problems. To address this research gap, we draw upon a subjectivist view of resource construction to investigate how and when HPM firms in emerging economies can rely on the tactic of bricolage to boost GM. We tested our research model on a sample of 180 chemical engineering manufacturing firms in China. Our results showed that HPM firms can rely on bricolage to positively implement GM, but its effects depend on the participation of different stakeholders. That is, firms can benefit more from bricolage in implementing GM when their suppliers can provide strong technical support and the moral requirements of the public are high. This study highlights the role of subjective resource construction activities in GM with the help of different stakeholder's participation in emerging economies and provides novel explanations and policy implications for this emerging phenomenon.
Treatment patterns, effectiveness, and patient‐reported outcomes of palbociclib therapy in Chinese patients with advanced breast cancer: A multicenter ambispective real‐world study
Authors: Shen Lesang , Zhou Jun , Chen Yiding , Ding Jinhua , Wei Haiyan , Liu Jian , Xia Wenjie , Xie Bojian , Xie Xiaohong , Li Xujun , Dai Yuechu , Zhang Guobing , Qiu Xia , Li Chao , Sun Shanshan , Chen Wuzhen , Gong Dihe , Li Hengyu , Huang Jian , Jiang Xia , Ni Chao
Published: April 2022

Background

Palbociclib was the only available cyclin‐dependent kinase 4/6 inhibitor in China until very recently, and its effect has not been systemically evaluated among Chinese patients. This study aims to assess the efficacy, safety and patient‐reported outcomes (PROs) of palbociclib plus endocrine therapy (ET) in real‐world China.

Methods

An ambispective cohort study was conducted on patients with advanced HR+HER2− breast cancer who received palbociclib between July 2018, and November 2020 and were enrolled from 12 hospitals. Treatment patterns, survival outcomes, and safety events were documented, and PROs (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire‐Core 30 items [EORTC QLQ‐C30] and EuroQoL 5 dimensions [EQ‐5D]) were analyzed. The Kaplan–Meier method was used to visualize and estimate the median progression‐free survival (mPFS). Log‐rank tests, Cox regressions, t tests, and chi‐square tests were performed for comparison.

Results

A total of 190 patients (median follow‐up of 18.0 months) were enrolled. Palbociclib was mostly combined with aromatase inhibitors (66.3%), fulvestrant (32.6%), and tamoxifen (1.1%). The mPFS values were 21.0, 14.0, and 7.0 months with palbociclib administered in first‐ (n = 83), second‐ (n = 41) and subsequent‐line settings (n = 66), respectively. Endocrine sensitivity was significantly associated with patient prognosis (mPFS: 23.0, 12.0, and 6.0 months for endocrine naïve, acquired, and primary resistant patients, respectively, p < 0.01). The outcome was worse for patients who failed to meet the inclusion criteria of PALOMA‐3 than for those who met the criteria (later‐line: 6.0 months vs. 9.0 months). The most common adverse events (AEs) were neutropenia (74.2%; grade 3/4: 30.0%), fatigue (48.4%), anemia (32.6%), and thrombocytopenia (22.1%). PRO data suggested that palbociclib plus ET significantly improved cognitive and emotional function, pain symptoms, and overall quality of life.

Conclusions

Palbociclib is effective for front‐line use and for treating endocrine‐sensitive patients in real‐world China and is generally well tolerated. The prevalence of AEs in the Chinese population is different from that reported in the PALOMA‐2/3 trials.
Cultural congruity and extensions of corporate heritage brands: An empirical analysis of time‐honored brands in China
Authors: Zhou Luyang , Hui Michael K. , Zhou Lianxi , Li Shengxiao
Published: April 2022

This article furthers the understanding of cultural congruity in relation to extension evaluations of corporate heritage brands. The extension of corporate heritage brands remains challenging, due to their unique identities around heritage—typically fostering a narrow spectrum of product‐cultural domain. Drawing on the concept of cultural congruity, this paper puts forward the notion that one effective way to break the deadlock of a brand's heritage is to expand into product categories that share the unique cultural heritage in ways that are meaningful, not merely symbolic. Based on data from a large survey on time‐honored brands in China, this paper demonstrates that cultural congruity does not only influence extension evaluations directly, but also indirectly through perceived fit. The findings further indicate that brand cultural heritage positively moderates both direct and indirect effects. This study enhances the concept of product fit from the lens of cultural congruity and opens up a new avenue for managing corporate heritage brands in the marketplace.
COVID‐19 and COVID‐19 vaccine‐related dermatological reactions: An interesting case series with a narrative review of the potential critical and non‐critical mucocutaneous adverse effects related to virus, therapy, and the vaccination
Authors: Pour Mohammad Arash , Mashayekhi Farzaneh , Seirafianpour Farnoosh , Gholizadeh Mesgarha Milad , Goodarzi Azadeh
Published: April 2022

This narrative review article was conducted to lay out a summarized but exhaustive review of current literature over mucocutaneous manifestations in 4 dimensions of SARS‐CoV‐2 pandemic: virus itself, treatment‐related, vaccine‐induced, and alteration of chronic dermatologic diseases following infection. Virus and vaccine‐related were mainly self‐limited and non‐severe. Treatment‐related reactions could be life‐threatening.
Determining the Scope 3 Emissions of Companies
Authors: Schmidt Mario , Nill Moritz , Scholz Johannes
Published: April 2022

The use of materials, goods, and services is associated with greenhouse gas emissions. These so‐called scope 3 emissions make a considerable contribution to the climate footprints of companies. Calculating these emissions is difficult because they occur in the supply chain, which can usually only be traced to the first supplier. Economic input‐output analysis methods can be used to estimate emissions in supply chains. They provide indications of the origin of emissions by country and industry sector or product group. With recursive methods in the supply chain, these calculations can be continuously improved.
Study on molecular structure and association behaviour of heavy subfractions of vacuum residue by an improved separation method
Authors: Tian Feng , Han Wei , Zhu Yonghong , Wang Yijie , Fan Xiaoyong , Du Chongpeng , Wang Feili , Zheng Huaan , Teng Haipeng , Li Dong
Published: April 2022

Vacuum residue (VR) is the most complex component of crude oil. Due to the special structure of heavy subfractions, physical aggregation and chemical coking reactions easily occur through molecular force, which affects the normal processing. Therefore, in‐depth study and analysis of their composition, structure and association behaviours are particularly important. In view of the shortcomings of the traditional separation method in terms of separation accuracy, mainly including the purification of asphaltenes and the poor separation of resins. In this paper, a reasonably improved separation method is adopted, and the multi‐stage asphaltene extraction and the multi‐stage silica gel coupling separation are carried out innovatively, which achieves a high yield of 99% while ensuring the separation accuracy. The samples were characterized by elemental analysis (EA), gel permeation chromatography (GPC), Fourier‐transform infrared spectroscopy (FT‐IR), hydrogen nuclear magnetic resonance spectroscopy (1H‐NMR), X‐ray photoelectron spectroscopy (XPS), X‐ray diffraction (XRD), and scanning electron microscope (SEM) to study their structural characteristics and association behaviours. The results show that the main forms of heteroatoms in asphaltene and resin surface are C‐O‐C, C‐OH, pyridine, pyrrole, and thiophene, and the content of these substances is higher in asphaltene. Compared with resins, asphaltenes contain a more peri‐condensed aromatic structure and shorter alkyl substituent side chains. By studying the hydrogen bond and acid–base interaction, it is found that asphaltene and resin mainly contain OH‐OH, OH‐π, and OH‐ether O, of which the content of OH‐OH is the highest. Asphaltene and resin have more neutral and basic substances. These hydrogen bonds and acid–base interactions caused by heteroatoms are the main forces for the association of the heavy subfractions of the VR.
Developmental neuroanatomy of the rosy bitterling Rhodeus ocellatus (Teleostei: Cypriniformes)—A microCT study
Authors: Yi Wenjing , Mueller Thomas , Rücklin Martin , Richardson Michael K.
Published: April 2022

Bitterlings are carp‐like teleost fish (Cypriniformes: Acheilanathidae) known for their specialized brood parasitic lifestyle. Bitterling embryos, in fact, develop inside the gill chamber of their freshwater mussel hosts. However, little is known about how their parasitic lifestyle affects brain development in comparison to nonparasitic species. Here, we document the development of the brain of the rosy bitterling, Rhodeus ocellatus, at four embryonic stages of 165, 185, 210, 235 hours postfertilization (hpf) using micro‐computed tomography (microCT). Focusing on developmental regionalization and brain ventricular organization, we relate the development of the brain divisions to those described for zebrafish using the prosomeric model as a reference paradigm. Segmentation and three‐dimensional visualization of the ventricular system allowed us to identify changes in the longitudinal brain axis as a result of cephalic flexure during development. The results show that during early embryonic and larval development, histological differentiation, tissue boundaries, periventricular proliferation zones, and ventricular spaces are all detectable by microCT. The results of this study visualized with differential CT profiles are broadly consistent with comparable histological studies, and with the genoarchitecture of teleosts like the zebrafish. Compared to the zebrafish, our study identifies distinct developmental heterochronies in the rosy bitterling, such as a precocious development of the inferior lobe.
Malignant granular cell tumors: Combining cytological and pathological findings for a definitive diagnosis
Authors: Enomoto Atsumi , Terasaki Mika , Murase Yukihiro , Kitagawa Yasuyuki , Shimizu Akira , Ohashi Ryuji , Terasaki Yasuhiro
Published: April 2022

Malignant granular cell tumors (GCTs) account for less than 2% of all GCTs and mainly occur in the deep soft tissue of the thigh or trunk. Malignant GCTs are highly aggressive tumors with high rates of recurrence and metastasis. In this brief report, we describe a rare case of malignant GCT in a 64‐year‐old Japanese man who presented with a 14 × 20 cm mass in the left inguinal region. The cytologic findings of fine‐needle aspiration (FNA) revealed atypical epithelial‐like granular cells with granular substance in the background, which was difficult to differentiate from apocrine carcinoma or melanoma. The immunohistochemistry (IHC) findings of the needle biopsy revealed that the tumor cells were positive for S‐100 and lysosomal marker CD68 which was suggestive of a GCT. However, the presence of crush artifacts made it challenging to identify cellular atypia, which is a characteristic of malignant tumor. Taken together, the FNA and needle biopsy results were suggestive of malignant GCT. The importance of preoperative diagnosis of malignant GCT is well known, but few reports have described its cytological findings. In our brief report, we show that combining cytological FNA and biopsy findings with IHC findings achieves an accurate diagnosis of malignant GCT.
Near‐term phytoplankton forecasts reveal the effects of model time step and forecast horizon on predictability
Authors: Woelmer Whitney M. , Thomas R. Quinn , Lofton Mary E. , McClure Ryan P. , Wander Heather L. , Carey Cayelan C.
Published: April 2022

As climate and land use increase the variability of many ecosystems, forecasts of ecological variables are needed to inform management and use of ecosystem services. In particular, forecasts of phytoplankton would be especially useful for drinking water management, as phytoplankton populations are exhibiting greater fluctuations due to human activities. While phytoplankton forecasts are increasing in number, many questions remain regarding the optimal model time step (the temporal frequency of the forecast model output), time horizon (the length of time into the future a prediction is made) for maximizing forecast performance, as well as what factors contribute to uncertainty in forecasts and their scalability among sites. To answer these questions, we developed near‐term, iterative forecasts of phytoplankton 1–14 days into the future using forecast models with three different time steps (daily, weekly, fortnightly), that included a full uncertainty partitioning analysis at two drinking water reservoirs. We found that forecast accuracy varies with model time step and forecast horizon, and that forecast models can outperform null estimates under most conditions. Weekly and fortnightly forecasts consistently outperformed daily forecasts at 7‐day and 14‐day horizons, a trend that increased up to the 14‐day forecast horizon. Importantly, our work suggests that forecast accuracy can be increased by matching the forecast model time step to the forecast horizon for which predictions are needed. We found that model process uncertainty was the primary source of uncertainty in our phytoplankton forecasts over the forecast period, but parameter uncertainty increased during phytoplankton blooms and when scaling the forecast model to a new site. Overall, our scalability analysis shows promising results that simple models can be transferred to produce forecasts at additional sites. Altogether, our study advances our understanding of how forecast model time step and forecast horizon influence the forecastability of phytoplankton dynamics in aquatic systems and adds to the growing body of work regarding the predictability of ecological systems broadly.
Strategies for managing marine disease
Authors: Glidden Caroline K. , Field Laurel C. , Bachhuber Silke , Hennessey Shannon M. , Cates Robyn , Cohen Lesley , Crockett Elin , Degnin Michelle , Feezell Maya K. , Fulton‐Bennett Heather K. , Pires Devyn , Poirson Brittany N. , Randell Zachary H. , White Erick , Gravem Sarah A.
Published: April 2022

The incidence of emerging infectious diseases (EIDs) has increased in wildlife populations in recent years and is expected to continue to increase with global environmental change. Marine diseases are relatively understudied compared with terrestrial diseases but warrant parallel attention as they can disrupt ecosystems, cause economic loss, and threaten human livelihoods. Although there are many existing tools to combat the direct and indirect consequences of EIDs, these management strategies are often insufficient or ineffective in marine habitats compared with their terrestrial counterparts, often due to fundamental differences between marine and terrestrial systems. Here, we first illustrate how the marine environment and marine organism life histories present challenges and opportunities for wildlife disease management. We then assess the application of common disease management strategies to marine versus terrestrial systems to identify those that may be most effective for marine disease outbreak prevention, response, and recovery. Finally, we recommend multiple actions that will enable more successful management of marine wildlife disease emergencies in the future. These include prioritizing marine disease research and understanding its links to climate change, improving marine ecosystem health, forming better monitoring and response networks, developing marine veterinary medicine programs, and enacting policy that addresses marine and other wildlife diseases. Overall, we encourage a more proactive rather than reactive approach to marine wildlife disease management and emphasize that multidisciplinary collaborations are crucial to managing marine wildlife health.
Disentangling spatial and environmental effects: Flexible methods for community ecology and macroecology
Authors: Viana Duarte S. , Keil Petr , Jeliazkov Alienor
Published: April 2022

Community ecologists and macroecologists have long sought to evaluate the importance of environmental conditions in determining species distributions, community composition, and diversity across sites. Different methods have been used to estimate species–environment relationships, but their differences to jointly fit and disentangle spatial autocorrelation and structure remain poorly studied. We compared how methods in four broad families of statistical models estimated the contribution of the environment and space to variation in species occurrence and abundance. These methods included redundancy analysis (RDA), generalized linear models (GLMs), generalized additive models (GAMs), and three types of tree‐based machine learning (ML) methods: boosted regression trees (BRT), random forests, and regression trees. The spatial component of the model consisted of Moran's eigenvector maps (MEMs; in RDA, GLM, and ML), smooth spatial splines (in GAM), or tree‐based nonlinear modeling of spatial coordinates (in ML). We simulated typical site‐by‐species data to assess the methods' performance in (1) fitting environmental and spatial models, and (2) partitioning the variation explained by environmental and spatial predictors. We observed marked differences in performance among methods generally caused by their different performances in fitting spatial structures. Generalized linear model and BRT with MEMs were generally the most reliable methods for partitioning the variation explained by environmental and spatial effects across a wide range of simulated scenarios. The remaining methods tended to underestimate pure spatial effects, because of either underfitting of simulated spatial structures or overestimation of environmental effects compared to spatial effects when jointly estimated. Performing variation partitioning on nine different empirical datasets using these methods yielded contrasting results, especially in the estimation of the spatial fraction of variation. Our results suggest that previously overlooked methods for performing variation partitioning, especially tree‐based ML, offer flexible approaches to analyze site‐by‐species matrices. We provide general guidelines on the usefulness of different models under different ecological and sampling scenarios, for species distribution modeling, community ecology, and macroecology.
Enriched puree potato with soy protein for dysphagia patients by using 3D printing
Authors: Mirazimi Farnaz , Saldo Jordi , Sepulcre Francesc , Gràcia Alvar , Pujola Montserrat
Published: April 2022

Dysphagia affects a person's ability to swallow, and it causes health problems by directly limiting nutritional intake, being the elderly the most at‐risk group and also likely to be deficient in nutrition. Diets for patients with dysphagia require textural modifications to offer soft and safe food to swallow. Puree is easily consumed by the elderly, being an alternative food preparation providing essential nutrition for people with dysphagia. In this study, we aimed to create different formulations with soy protein and agar added to potato puree to add nutritional value and end up with printable material by designing food for the elderly and people with dysphagia. Some enriched potato puree formulations were obtained by adding soy protein (3%, 5%, and 7%) and up to 0.2% agar. The use of three‐dimensional food printing allows visual customization with appeal benefits of nutritional food formulations for specific consumers. The rheology and texture profile analysis of the different formulations has been performed. According to International Dysphagia Diet Standardisation Initiative (IDDSI) scales, the texture of all modified samples was suitable for people with swallowing difficulties. The samples with agar presented a better‐printed shape and a more viscous‐like behavior than the samples with soy protein. These findings highlight that soy protein could modify the texture and, from the nutritional point of view, add value to the formulations. The addition of 0.2% agar can establish good material for designing three‐dimensional (3D)‐printed food that allows the creation of textures in accordance with the needs of the elderly and people with dysphagia.