bluuebunny/crossref_metadata_2025 huggingface dataset:
Quality of Life in Adults with Neurofibromatosis 1 in Brazil
Authors: Bicudo Natália Parenti , de Menezes Neto Balduíno Ferreira , da Silva de Avó Lucimar Retto , Germano Carla Maria Ramos , Melo Débora Gusmão
Published: March 2016

Neurofibromatosis type 1 (NF1) is a neurocutaneous genetic disorder that can be associated with severe complications, and it may shorten patients’ lifespan and affect their quality of life negatively. This study aimed to examine quality of life constructs among adults with NF1 in Brazil. It is an exploratory, descriptive and cross‐sectional study consisting of two stages, involving thirteen adult patients with NF1. The first stage was developed using a quantitative methodology, namely the WHOQOL‐100 questionnaire; responses for the 13 patients were compared to a matched control group. The second stage comprised clinical‐qualitative research whereby participants took part in a semi‐structured interview; these data were analyzed using the categorical thematic analysis technique. There were no statistically significant differences in the questionnaire domains between the NF1 patients and the control subjects. Eighteen main themes were extracted from the interviews, showing interference of the NF1 visibility principally in psychological aspects and social relationships. Patients mentioned curiosity about NF1 and confusion about the distinctions between NF1 and contagious diseases, which lead to prejudice. They were concerned about the future and how the disease would develop in themselves and their offspring, and emphasized difficulties acquiring proper healthcare. These findings may help in planning healthcare for Brazilian NF1 patients and improving their quality of life.
Integrative clustering methods of multi‐omics data for molecule‐based cancer classifications
Authors: Wang Dongfang , Gu Jin
Published: March 2016

One goal of precise oncology is to re‐classify cancer based on molecular features rather than its tissue origin. Integrative clustering of large‐scale multi‐omics data is an important way for molecule‐based cancer classification. The data heterogeneity and the complexity of inter‐omics variations are two major challenges for the integrative clustering analysis. According to the different strategies to deal with these difficulties, we summarized the clustering methods as three major categories: direct integrative clustering, clustering of clusters and regulatory integrative clustering. A few practical considerations on data pre‐processing, post‐clustering analysis and pathway‐based analysis are also discussed.
Early life adversities or high fat diet intake reduce cognitive function and alter BDNF signaling in adult rats: Interplay of these factors changes these effects
Authors: Arcego Danusa Mar , Krolow Rachel , Lampert Carine , Toniazzo Ana Paula , Berlitz Carolina , Lazzaretti Camilla , Schmitz Felipe , Rodrigues André Felipe , Wyse Angela T.S. , Dalmaz Carla
Published: March 2016

Environmental factors, like early exposure to stressors or high caloric diets, can alter the early programming of central nervous system, leading to long‐term effects on cognitive function, increased vulnerability to cognitive decline and development of psychopathologies later in life. The interaction between these factors and their combined effects on brain structure and function are still not completely understood. In this study, we evaluated long‐term effects of social isolation in the prepubertal period, with or without chronic high fat diet access, on memory and on neurochemical markers in the prefrontal cortex of rats. We observed that early social isolation led to impairment in short‐term and working memory in adulthood, and to reductions of Na+,K+‐ATPase activity and the immunocontent of phospho‐AKT, in prefrontal cortex. Chronic exposure to a high fat diet impaired short‐term memory (object recognition), and decreased BDNF levels in that same brain area. Remarkably, the association of social isolation with chronic high fat diet rescued the memory impairment on the object recognition test, as well as the changes in BDNF levels, Na+,K+‐ATPase activity, MAPK, AKT and phospho‐AKT to levels similar to the control‐chow group. In summary, these findings showed that a brief social isolation period and access to a high fat diet during a sensitive developmental period might cause memory deficits in adulthood. On the other hand, the interplay between isolation and high fat diet access caused a different brain programming, preventing some of the effects observed when these factors are separately applied.
Effect of aqueous extract of Moringa oleifera leaves on pharmacological models of epilepsy and anxiety in mice
Authors: Ingale Suvarna , Gandhi Foram
Published: March 2016

Objective Among the psychiatric co-morbidities in epilepsy, anxiety disorders are highly frequent and have profound influence on the quality of life of epilepsy patients. Moringa oleifera Lam. (Moringaceae) is used in traditional medicine to treat various ailments including anxiety and epilepsy. However, no scientific evidence exists to support its use. We studied antiepileptic and anxiolytic activities of aqueous extract of Moringa oleifera Lam. leaves (AEMO).

Methods Antiepileptic activity was evaluated using pentylenetetrazole (PTZ) induced seizure and maximum electroshock (MES) induced seizure test and anxiolytic activity was evaluated using elevated plus maze, light/dark box and hole board test.

Results In present study, AEMO (250, 375 and 500 mg/kg, i.p.) demonstrated significant antiepileptic and anxiolytic effects. To study involvement of GABA in anxiolytic and antiepileptic activity of AEMO, we also evaluated effect of AEMO on Baclofen induced catatonia, a GABA mediated behavior, wherein AEMO significantly potentiated (preponed) baclofen induced catatonia, which is suggestive of its GABA mimetic action.

Conclusion Thus, it may be concluded that aqueous extract of M. oleifera possess anxiolytic and antiepileptic effects possibly mediated via of GABA mimetic action and these findings authenticate the traditional claims about use of Moringa oleifera in treatment of epilepsy and anxiety.
Can urinary nitrites or other urinalysis findings be a predictor of bacterial resistance of uncomplicated urinary tract infections?
Authors: Medows Marsha , Nijres Bassel Mohammad , Elbakoush Faesal , Alali Abdulrazak , Patel Rifali , Sami Mohammad
Published: March 2016

Background and objectives:

To evaluate whether initial urinalysis (UA) and urinary nitrite results can be used as a proxy for choosing empiric antibiotic therapy.

Materials and methods:

A retrospective study was conducted in an urban inner city community hospital in New York City (NYU Woodhull Medical Center). We reviewed the charts of patients seen in the Emergency Department and Pediatric Clinic who had a diagnosis of urinary tract infection (UTI) during a 3 year time period (January 2010—December 2012). Statistical analysis was performed using SPSS 20.0 statistical software.

Results:

Between January 2010 and December 2012, a total of 378 patients had a diagnosis of UTI. Seventy-five (19.8%) were males and 203 (80.2%) were females. Of the 378 patients with a diagnosis of UTI, the most common isolated pathogen was Escherichia coli, which was detected in 283 (74.9%) isolates. Other bacteria included Klebsiella spp 30 (7.9%), Proteus 21 (5.6%), Enterococcus 14 (3.7%), and others 30 (7.9%). The resistance rate was higher in the nitrite positive group for the following antibiotics: TMP/SMX and ampicillin with or without sulbactam. No significant correlation was found with the remaining studied antibiotics. No significant correlation was found between leukoesterase and the resistance patterns in all of the studied antibiotics, except cefazolin.

Conclusion:

Urinary nitrite results are not helpful in choosing an initial antibiotic to treat a UTI. Leukocytosis in the blood or urine or the presence of a fever cannot be used to predict bacterial resistance. The use of nitrofurantoin or cephalexin for the treatment of cystitis was optimum, and in the presence of negative leukoesterase, nitrofurantoin was preferable to cephalexin.
Bullying in early adolescence
Authors: AlBuhairan Fadia S. , Al Eissa Majid , Alkufeidy Nourah , Almuneef Maha
Published: March 2016

Background and objectives:

This study aimed to gain a deeper understanding of bullying among intermediate school students in Saudi Arabia to inform preventive measures.

Materials and methods:

Qualitative methods were applied. The study was conducted at four intermediate schools. Students, parents, and school professionals participated, and data were collected through observations, interviews, and focus groups. Emergent themes and sub-themes were identified through coding.

Results:

A total of 91 individuals participated: 40 students, 31 school professionals, and 20 parents/caregivers. Three main themes and multiple subthemes were identified: 1) types of bullying, 2) factors encouraging bullying, and 3) the impact of bullying. The lack of safe environments, recreational facilities, and inconsistencies in addressing problematic behaviors were subthemes that were found to be conducive to bullying, whereas dislike of school, racism, aggressiveness, and social isolation were emergent subthemes that were reflective of the potential impact of bullying. With this process, a model for bullying practices is described.

Conclusion:

A better understanding of the bullying experiences among adolescents has been obtained. Preventive measures need to target the factors that the participants identified as conducive to bullying.
The ALFA project: A research platform to identify early pathophysiological features of Alzheimer's disease
Authors: Molinuevo José Luis , Gramunt Nina , Gispert Juan Domingo , Fauria Karine , Esteller Manel , Minguillon Carolina , Sánchez‐Benavides Gonzalo , Huesa Gema , Morán Sebastián , Dal‐Ré Rafael , Camí Jordi
Published: March 2016

Introduction

The preclinical phase of Alzheimer's disease (AD) is optimal for identifying early pathophysiological events and developing prevention programs, which are shared aims of the ALFA project, including the ALFA registry and parent cohort and the nested ALFA+ cohort study.

Methods

The ALFA parent cohort baseline visit included full cognitive evaluation, lifestyle habits questionnaires, DNA extraction, and MRI. The nested ALFA+ study adds wet and imaging biomarkers for deeper phenotyping.

Results

A total of 2743 participants aged 45 to 74 years were included in the ALFA parent cohort. We show that this cohort, mostly composed of cognitively normal offspring of AD patients, is enriched for AD genetic risk factors.

Discussion

The ALFA project represents a valuable infrastructure that will leverage with different studies and trials to prevent AD. The longitudinal ALFA+ cohort will serve to untangle the natural history of the disease and to model the preclinical stages to develop successful trials.
Texts, Editors, and Readers
Authors: Tarrant Richard
Published: March 2016

This book re-examines the most traditional area of classical scholarship, offering critical assessments of the current state of the field, its methods and controversies, and its prospects for the future in a digital environment. Each stage of the editorial process is examined, from gathering and evaluating manuscript evidence to constructing the text and critical apparatus, with particular attention given to areas of dispute, such as the role of conjecture. The importance of subjective factors at every point is highlighted. An Appendix offers practical guidance in reading a critical apparatus. The discussion is framed in a way that is accessible to non-specialists, with all Latin texts translated. The book will be useful both to classicists who are not textual critics and to non-classicists interested in issues of editing.
Popular Politics in the Making of the Modern Middle East
Authors: Chalcraft John
Published: March 2016

The waves of protest ignited by the self-immolation of Muhammad Bouazizi in Tunisia in late 2010 highlighted for an international audience the importance of contentious politics in the Middle East and North Africa. John Chalcraft's ground-breaking account of popular protest emphasizes the revolutionary modern history of the entire region. Challenging top-down views of Middle Eastern politics, he looks at how commoners, subjects and citizens have long mobilised in defiance of authorities. Chalcraft takes examples from a wide variety of protest movements from Morocco to Iran. He forges a new narrative of change over time, creating a truly comparative framework rooted in the dynamics of hegemonic contestation. Beginning with movements under the Ottomans, which challenged corruption and oppression under the banners of religion, justice, rights and custom, this book goes on to discuss the impact of constitutional movements, armed struggles, nationalism and independence, revolution and Islamism. A work of unprecedented range and depth, this volume will be welcomed by undergraduates and graduates studying protest in the region and beyond.
Language Faculty Science
Authors: Hoji Hajime
Published: March 2016

This book explores how we can aspire to accumulate knowledge about the language faculty in line with Feynman's 'The test of all knowledge is experiment'. The two pillars of the proposed methodology for language faculty science are the internalist approach advocated by Chomsky and what Feynman calls the 'Guess-Compute-Compare' method. Taking the internalist approach, the book is concerned with the I-language of an individual speaker. Adopting the Guess-Compute-Compare method, it aims at deducing definite predictions and comparing them with experimental results. It offers a conceptual articulation of how we deduce definite predictions about the judgments of an individual speaker on the basis of universal and language-particular hypotheses and how we obtain experimental results precisely in accordance with such predictions. In pursuit of rigorous testability and reproducibility, the experimental demonstration in the book is supplemented by an accompanying website which provides the details of all the experiments discussed in the book.
Literature in the Digital Age
Authors: Hammond Adam
Published: March 2016

Literature in a Digital Age: An Introduction guides readers through the most salient theoretical, interpretive, and creative possibilities opened up by the shift to digital literary forms such as e-books, digital archives, and electronic literature. While Digital Humanities (DH) has been hailed as the 'next big thing' in literary studies, many students and scholars remain perplexed as to what a DH approach to literature entails, and skeptical observers continue to see literature and the digital world as fundamentally incompatible. In its argument that digital and traditional scholarship should be placed in dialogue with each other, this book contextualizes the advent of the digital in literary theory, explores the new questions readers can ask of texts when they become digitized, and investigates the challenges that fresh forms of born-digital fiction pose to existing models of literary analysis.
Applied Psychology
Authors: Geller E. Scott
Published: March 2016

This volume demonstrates how readers can become more effective parents, teachers, students, coaches, managers, or work supervisors, while also gaining practical skills to enhance their self-motivation, communication skills, and intervention acumen. The first eight chapters explain evidence-based principles from applied behavioral science (ABS) that can be used to improve the human dynamics of any situation involving behavior. Fundamentals from humanism are integrated strategically to show how an ABS intervention can be more acceptable, influential, and sustainable. The following twelve chapters detail the deployment of ABS interventions to optimize performance in a wide variety of fields, including occupational and transportation safety, quantity and quality of organizational work behavior, healthcare, athletic coaching, parenting, pre-school and college education, environmental sustainability, and the control of obesity and alcohol abuse. Applied Psychology provides a thorough review of the latest research in relation to these domains and explores issues for future investigation.
Confidence, Likelihood, Probability
Authors: Schweder Tore , Hjort Nils Lid
Published: March 2016

This lively book lays out a methodology of confidence distributions and puts them through their paces. Among other merits, they lead to optimal combinations of confidence from different sources of information, and they can make complex models amenable to objective and indeed prior-free analysis for less subjectively inclined statisticians. The generous mixture of theory, illustrations, applications and exercises is suitable for statisticians at all levels of experience, as well as for data-oriented scientists. Some confidence distributions are less dispersed than their competitors. This concept leads to a theory of risk functions and comparisons for distributions of confidence. Neyman–Pearson type theorems leading to optimal confidence are developed and richly illustrated. Exact and optimal confidence distribution is the gold standard for inferred epistemic distributions. Confidence distributions and likelihood functions are intertwined, allowing prior distributions to be made part of the likelihood. Meta-analysis in likelihood terms is developed and taken beyond traditional methods, suiting it in particular to combining information across diverse data sources.
3264 and All That
Authors: Eisenbud David , Harris Joe
Published: March 2016

This book can form the basis of a second course in algebraic geometry. As motivation, it takes concrete questions from enumerative geometry and intersection theory, and provides intuition and technique, so that the student develops the ability to solve geometric problems. The authors explain key ideas, including rational equivalence, Chow rings, Schubert calculus and Chern classes, and readers will appreciate the abundant examples, many provided as exercises with solutions available online. Intersection is concerned with the enumeration of solutions of systems of polynomial equations in several variables. It has been an active area of mathematics since the work of Leibniz. Chasles' nineteenth-century calculation that there are 3264 smooth conic plane curves tangent to five given general conics was an important landmark, and was the inspiration behind the title of this book. Such computations were motivation for Poincaré's development of topology, and for many subsequent theories, so that intersection theory is now a central topic of modern mathematics.
Rifts and Passive Margins
Authors: Nemčok Michal
Published: March 2016

Rifts and passive margins are extremely important for the petroleum industry, as they are areas of high sedimentation and can contain significant oil and gas resources. This book provides a comprehensive understanding of rifts and passive margins as a whole. It synthesises in one volume the existing information devoted to specific aspects of these vitally important hydrocarbon habitats. This collecting together of state-of-the-art information on the topic facilitates the better use of this knowledge to assess the risks of exploring and operating in these settings and the development of systematic and predictive hydrocarbon screening tools. The book will be invaluable for a broad range of readers, from advanced geology students and researchers to exploration geoscientists to exploration managers exploring for and developing hydrocarbon resources in analogous settings.
Thermodynamic Foundations of the Earth System
Authors: Kleidon Axel
Published: March 2016

Thermodynamics sets fundamental laws for all physical processes and is central to driving and maintaining planetary dynamics. But how do Earth system processes perform work, where do they derive energy from, and what are the limits? This accessible book describes how the laws of thermodynamics apply to Earth system processes, from solar radiation to motion, geochemical cycling and biotic activity. It presents a novel view of the thermodynamic Earth system explaining how it functions and evolves, how different forms of disequilibrium are being maintained, and how evolutionary trends can be interpreted as thermodynamic trends. It also offers an original perspective on human activity, formulating this in terms of a thermodynamic, Earth system process. This book uses simple conceptual models and basic mathematical treatments to illustrate the application of thermodynamics to Earth system processes, making it ideal for researchers and graduate students across a range of Earth and environmental science disciplines.
Interactions with Search Systems
Authors: White Ryen W.
Published: March 2016

Information seeking is a fundamental human activity. In the modern world, it is frequently conducted through interactions with search systems. The retrieval and comprehension of information returned by these systems is a key part of decision making and action in a broad range of settings. Advances in data availability coupled with new interaction paradigms, and mobile and cloud computing capabilities, have created a broad range of new opportunities for information access and use. In this comprehensive book for professionals, researchers, and students involved in search system design and evaluation, search expert Ryen White discusses how search systems can capitalize on new capabilities and how next-generation systems must support higher order search activities such as task completion, learning, and decision making. He outlines the implications of these changes for the evolution of search evaluation, as well as challenges that extend beyond search systems in areas such as privacy and societal benefit.
The Channel
Authors: Morieux Renaud
Published: March 2016

Rather than a natural frontier between natural enemies, this book approaches the English Channel as a shared space, which mediated the multiple relations between France and England in the long eighteenth century, in both a metaphorical and a material sense. Instead of arguing that Britain's insularity kept it spatially and intellectually segregated from the Continent, Renaud Morieux focuses on the Channel as a zone of contact. The 'narrow sea' was a shifting frontier between states and a space of exchange between populations. This richly textured history shows how the maritime border was imagined by cartographers and legal theorists, delimited by state administrators and transgressed by migrants. It approaches French and English fishermen, smugglers and merchants as transnational actors, whose everyday practices were entangled. The variation of scales of analysis enriches theoretical and empirical understandings of Anglo-French relations, and reassesses the question of Britain's deep historical connections with Europe.
The Smoke of London
Authors: Cavert William M.
Published: March 2016

The Smoke of London uncovers the origins of urban air pollution, two centuries before the industrial revolution. By 1600, London was a fossil-fuelled city, its high-sulfur coal a basic necessity for the poor and a source of cheap energy for its growing manufacturing sector. The resulting smoke was found ugly and dangerous throughout the seventeenth and eighteenth centuries, leading to challenges in court, suppression by the crown, doctors' attempts to understand the nature of good air, increasing suburbanization, and changing representations of urban life in poetry and on the London stage. Neither a celebratory account of proto-environmentalism nor a declensionist narrative of degradation, The Smoke of London recovers the seriousness of pre-modern environmental concerns even as it explains their limits and failures. Ultimately, Londoners learned to live with their dirty air, an accommodation that reframes the modern process of urbanization and industrial pollution, both in Britain and beyond.
Technical Ekphrasis in Greek and Roman Science and Literature
Authors: Roby Courtney
Published: March 2016

Ekphrasis is familiar as a rhetorical tool for inducing enargeia, the vivid sense that a reader or listener is actually in the presence of the objects described. This book focuses on the ekphrastic techniques used in ancient Greek and Roman literature to describe technological artifacts. Since the literary discourse on technology extended beyond technical texts, this book explores 'technical ekphrasis' in a wide range of genres, including history, poetry, and philosophy as well as mechanical, scientific, and mathematical works. Technical authors like Philo of Byzantium, Vitruvius, Hero of Alexandria, and Claudius Ptolemy are put into dialogue with close contemporaries in other genres, like Diodorus Siculus, Cicero, Ovid, and Aelius Theon. The treatment of 'technical ekphrasis' here covers the techniques of description, the interaction of verbal and visual elements, the role of instructions, and the balance between describing the artifact's material qualities and the other bodies of knowledge it evokes.
Corruption and Government
Authors: Rose-Ackerman Susan , Palifka Bonnie J.
Published: March 2016

The second edition of Corruption and Government updates Susan Rose-Ackerman's 1999 book to address emerging issues and to rethink old questions in light of new data. The book analyzes the research explosion that accompanied the fall of the Berlin Wall, the founding of Transparency International, and the World Bank's decision to give anti-corruption policy a key place on its agenda. Time has vindicated Rose-Ackerman's emphasis on institutional reform as the necessary condition for serious progress. The book deals with routine payoffs and with corruption in contracting and privatization. It gives special attention to political corruption and to instruments of accountability. The authors have expanded the treatment of culture as a source of entrenched corruption and added chapters on criminal law, organized crime, and post-conflict societies. The book outlines domestic conditions for reform and discusses international initiatives - including both explicit anti-corruption policies and efforts to constrain money laundering.
Adaptive Behavior and Learning
Authors: Staddon J. E. R.
Published: March 2016

Every day at about 4:30, Jazz, a Hungarian Vizsla dog, leaps up on the sofa and looks out for his owner who always comes home at 5:00. He doesn't need an internal clock because he has an acute sense of smell that allows him to measure how long his master has been absent. Explaining complex behavior in simple ways, this book is a fascinating exploration of the evolution, development and processes of learning in animals. Now in its second edition, there is increased emphasis on development, evolution and dynamics; new accounts of taxic orientation, reflex induction, habituation and operant learning in organisms; more discussion of spatial learning and the processes underlying it; expanded chapters on choice and completely new chapters on molar laws, classical conditioning theories and comparative cognition. J. E. R. Staddon provides a definitive summary of contemporary theoretical understanding suitable for graduates and advanced undergraduates.
Tyrants
Authors: Newell Waller R.
Published: March 2016

The forces of freedom are challenged everywhere by a newly energized spirit of tyranny, whether it is Jihadist terrorism, Putin's imperialism, or the ambitions of China's dictatorship, writes Waller R. Newell in this engaging exposé of a thousand dangers. We will see why tyranny is a permanent threat by following its strange career from Homeric Bronze Age warriors, through the empires of Alexander the Great and Rome, to the medieval struggle between the City of God and the City of Man, leading to the state-building despots of the Modern Age including the Tudors and 'enlightened despots' such as Peter the Great. The book explores the psychology of tyranny from Nero to Gaddafi, and how it changes with the Jacobin Terror into millenarian revolution. Stimulating and enlightening, Tyrants: A History of Power, Injustice, and Terror will appeal to anyone interested in the danger posed by tyranny and terror in today's world.
Bach's Numbers
Authors: Tatlow Ruth
Published: March 2016

In eighteenth-century Germany the universal harmony of God's creation and the perfection of its proportions still held philosophical, moral and devotional significance. Reproducing proportions close to the unity (1:1) across compositions could render them beautiful, perfect and even eternal. Using the principles of her groundbreaking theory of proportional parallelism and the latest source study research, Ruth Tatlow reveals how Bach used the number of bars to create numerical perfection across his published collections, and explains why he did so. The first part of the book illustrates the wide-ranging application of belief in the unity, showing how planning a well-proportioned structure was a normal compositional procedure in Bach's time. In the second part Tatlow presents practical demonstrations of this in Bach's works, illustrating the layers of proportion that appear within a movement, a work, between two works in a collection, across a collection and between collections.
Debating Early Child Care
Authors: Crosnoe Robert , Leventhal Tama
Published: March 2016

Throughout distressing cultural battles and disputes over child care, each side claims to have the best interests of children at heart. While developmental scientists have concrete evidence for this debate, their message is often lost or muddied by the media. To demonstrate why this problem matters, this book examines the extensive media coverage of the NICHD Study of Early Child Care and Youth Development – a long-running government-funded study that provides the most comprehensive look at the effects of early child care on American children. Analyses of newspaper articles and interviews with scientists and journalists reveal what happens to science in the public sphere and how children's issues can be used to question parents' choices. By shining light on these issues, the authors bring clarity to the enduring child care wars while providing recommendations for how scientists and the media can talk to – rather than past – each other.
Affective Communities in World Politics
Authors: Hutchison Emma
Published: March 2016

Emotions underpin how political communities are formed and function. Nowhere is this more pronounced than in times of trauma. The emotions associated with suffering caused by war, terrorism, natural disasters, famine and poverty can play a pivotal role in shaping communities and orientating their politics. This book investigates how 'affective communities' emerge after trauma. Drawing on several case studies and an unusually broad set of interdisciplinary sources, it examines the role played by representations, from media images to historical narratives and political speeches. Representations of traumatic events are crucial because they generate socially embedded emotional meanings which, in turn, enable direct victims and distant witnesses to share the injury, as well as the associated loss, in a manner that affirms a particular notion of collective identity. While ensuing political orders often re-establish old patterns, traumatic events can also generate new 'emotional cultures' that genuinely transform national and transnational communities.
India and the Islamic Heartlands
Authors: Sood Gagan D. S.
Published: March 2016

Based on the chance survival of a remarkable cache of documents, India and the Islamic Heartlands recaptures a vanished and forgotten world from the eighteenth century spanning much of today's Middle East and South Asia. Gagan Sood focuses on ordinary people - traders, pilgrims, bankers, clerics, brokers, scribes, among others - who were engaged in activities marked by large distances and long silences. By elucidating their everyday lives in a range of settings, from the family household to the polity at large, Sood pieces together the connective tissue of a world that lay beyond the sovereign purview. Recapturing this obscured and neglected world helps us better understand the region during a pivotal moment in its history, and offers new answers to old questions concerning early modern Eurasia and its transition to colonialism.
The Viennese Students of Civilization
Authors: Dekker Erwin
Published: March 2016

This book argues that the work of the Austrian economists, including Carl Menger, Joseph Schumpeter, Ludwig von Mises and Friedrich Hayek, has been too narrowly interpreted. Through a study of Viennese politics and culture, it demonstrates that the project they were engaged in was much broader: the study and defense of a liberal civilization. Erwin Dekker shows the importance of the civilization in their work and how they conceptualized their own responsibilities toward that civilization, which was attacked left and right during the interwar period. Dekker argues that what differentiates their position is that they thought of themselves primarily as students of that civilization rather than as social scientists, or engineers. This unique focus and approach is related to the Viennese setting of the circles, which constitute the heart of Viennese intellectual life in the interwar period.
The Burdens of Proof
Authors: Nance Dale A.
Published: March 2016

Adjudicative tribunals in both criminal and non-criminal cases rely on the concept of the 'burden of proof' to resolve uncertainty about facts. Perhaps surprisingly, this concept remains clouded and deeply controversial. Written by an internationally renowned scholar, this book explores contemporary thinking on the evidential requirements that are critical for all practical decision-making, including adjudication. Although the idea that evidence must favor one side over the other to a specified degree, such as 'beyond reasonable doubt', is familiar, less well-understood is an idea associated with the work of John Maynard Keynes, namely that there are requirements on the total amount of evidence considered to decide the case. The author expertly explores this distinct Keynesian concept and its implications. Hypothetical examples and litigated cases are included to assist understanding of the ideas developed. Implications include an expanded conception of the burden of producing evidence and how it should be administered.
The State, Antisemitism, and Collaboration in the Holocaust
Authors: Dumitru Diana
Published: March 2016

Based on original sources, this important new book on the Holocaust explores regional variations in civilians' attitudes and behavior toward the Jewish population in Romania and the occupied Soviet Union. Gentiles' willingness to assist Jews was greater in lands that had been under Soviet administration during the inter-war period, while gentiles' willingness to harm Jews occurred more in lands that had been under Romanian administration during the same period. While acknowledging the disasters of Communist rule in the 1920s and 1930s, this work shows the effectiveness of Soviet nationalities policy in the official suppression of antisemitism. This book offers a corrective to the widespread consensus that homogenizes gentile responses throughout Eastern Europe, instead demonstrating that what states did in the interwar period mattered; relations between social groups were not fixed and destined to repeat themselves, but rather fluid and susceptible to change over time.
God and Politics in Esther
Authors: Hazony Yoram
Published: March 2016

A political crisis erupts when the Persian government falls to fanatics, and a Jewish insider goes rogue, determined to save her people at all costs. God and Politics in Esther explores politics and faith. It is about an era in which the prophets have been silenced and miracles have ceased, and Jewish politics has come to depend not on commands from on high, but on the boldness and belief of each woman and man. Esther takes radical action to win friends and allies, reverse terrifying decrees, and bring God's justice into the world with her own hands. Hazony's The Dawn has long been a cult classic, read at Purim each year the world over. Twenty years on, this revised edition brings the book to much wider attention. Three controversial new chapters address the astonishingly radical theology that emerges from amid the political intrigues of the book.
The ASEAN Economic Community
Authors: Pelkmans Jacques
Published: March 2016

The Association of Southeast Asian Nations (ASEAN) has experienced rapid economic growth for many years. Although the population of ASEAN is larger than the EU-28, the emerging ASEAN market, called the ASEAN Economic Community (AEC), is still little understood by policy makers in many parts of the world, by business professionals and students, as well as by scholars in economics, business, politics and economic law. This book provides, for the first time, a rigorous analytical approach of the new AEC and its intricacies. It sets out its ambition, scrutinises its economic integration logic and detects its deficits. Besides a detailed analysis of the AEC Roadmap, the book also elaborates on its achievements. Several strategic economic options for the AEC, in particular as an instrument to accelerate the economic development of the region, are explored.
Incarceration Nation
Authors: Enns Peter K.
Published: March 2016

The rise of mass incarceration in the United States is one of the most critical outcomes of the last half-century. Incarceration Nation offers the most compelling explanation of this outcome to date. This book combines in-depth analysis of Barry Goldwater and Richard Nixon's presidential campaigns with sixty years of data analysis. The result is a sophisticated and highly accessible picture of the rise of mass incarceration. In contrast to conventional wisdom, Peter K. Enns shows that during the 1960s, 70s, 80s, and 90s, politicians responded to an increasingly punitive public by pushing policy in a more punitive direction. The book also argues that media coverage of rising crime rates helped fuel the public's punitiveness. Equally as important, a decline in public punitiveness in recent years offers a critical window into understanding current bipartisan calls for criminal justice reform.
Language Evolution
Authors: Botha Rudolf
Published: March 2016

How can we unravel the evolution of language, given that there is no direct evidence about it? Rudolf Botha addresses this intriguing question in his fascinating new book. Inferences can be drawn about language evolution from a range of other phenomena, serving as windows into this prehistoric process. These include shell-beads, fossil skulls and ancestral brains, modern pidgin and creole languages, homesign systems and emergent sign languages, modern motherese, language use of modern hunter-gatherers, first language acquisition, similarities between language and music, and comparative animal behaviour. The first systematic analysis of the Windows Approach, it will be of interest to students and researchers in many disciplines, including anthropology, archaeology, linguistics, palaeontology and primatology, as well as anyone interested in how language evolved.
Promoting Compliance
Authors: Beckman Robert , Bernard Leonardo , Phan Hao Duy , Tan Hsien-Li , Yusran Ranyta
Published: March 2016

The reputation and achievement of the ASEAN Community hinges on compliance. This seminal book discusses whether ASEAN's faith in dispute settlement and monitoring mechanisms as a means to better compliance is justified and delves into the extent to which they can facilitate ASEAN Community building. It provides the first comprehensive and systematic analysis of ASEAN's compliance with its instruments, and enables readers to see ASEAN as an organisation increasingly based on law and institutions. Readers will also learn how ASEAN balances a thin line between law and institutions on the one hand and diplomacy and realism on the other. Scholars of adjudicatory mechanisms will find this book a fascinating addition to the literature available, and it will serve as a 'go-to' reference for ASEAN state agencies. The book will also interest academics and practitioners working on comparative and cross-disciplinary studies of dispute settlement, monitoring mechanisms, compliance, and international and regional organisations.
Women Warriors and Wartime Spies of China
Authors: Edwards Louise
Published: March 2016

In this compelling new study, Louise Edwards explores the lives of some of China's most famous women warriors and wartime spies through history. Focusing on key figures including Hua Mulan, Zheng Pingru and Liu Hulan, this book examines the ways in which these extraordinary women have been commemorated through a range of cultural mediums including film, theatre, museums and textbooks. Whether perceived as heroes or anti-heroes, Edwards shows that both the popular and official presentation of these women and their accomplishments has evolved in line with China's shifting political values and circumstances over the past one hundred years. Written in a lively and accessible style with illustrations throughout, this book sheds new light on the relationship between gender and militarisation and the ways that women have been exploited to glamorise war both historically in the past and in China today.
The Rhetoric of Diversion in English Literature and Culture, 1690–1760
Authors: Domingo Darryl P.
Published: March 2016

Why did eighteenth-century writers employ digression as a literary form of diversion, and how did their readers come to enjoy linguistic and textual devices that self-consciously disrupt the reading experience? Darryl P. Domingo answers these questions through an examination of the formative period in the commercialization of leisure in England, and the coincidental coming of age of literary self-consciousness in works published between approximately 1690 and 1760. During this period, commercial entertainers tested out new ways of gratifying a public increasingly eager for amusement, while professional writers explored the rhetorical possibilities of intrusion, obstruction, and interruption through their characteristic use of devices like digression. Such devices adopt similar forms and fulfil similar functions in literature as do diversions in culture: they 'unbend the mind' and reveal the complex reciprocity between commercialized leisure and commercial literature in the age of Swift, Pope, and Fielding.
How Oceans Could Change If We Reverse Anthropogenic Warming
Authors: Shultz David
Published: March 2016

A computer simulation shows a net increase in primary production by phytoplankton if climate change were mitigated by 2200 but also indicates big changes in the makeup of those species.
The direct interaction of NME3 with Tip60 in DNA repair
Authors: Tsao Ning , Yang Ya-Chi , Deng Yu-Jyun , Chang Zee-Fen
Published: March 2016

Cellular supply of dNTPs via RNR (ribonucleotide reductase) is crucial for DNA replication and repair. It has been shown that DNA-damage-site-specific recruitment of RNR is critical for DNA repair efficiency in quiescent cells. The catalytic function of RNR produces dNDPs. The subsequent step of dNTP formation requires the function of NDP kinase. There are ten isoforms of NDP kinase in human cells. In the present study, we identified NME3 as one specific NDP kinase that interacts directly with Tip60, a histone acetyltransferase, to form a complex with RNR. Our data reveal that NME3 recruitment to DNA damage sites depends on this interaction. Disruption of interaction of NME3 with Tip60 suppressed DNA repair in serum-deprived cells. Thus Tip60 interacts with RNR and NME3 to provide site-specific synthesis of dNTP for facilitating DNA repair in serum-deprived cells which contain low levels of dNTPs.
Amino acids trigger down-regulation of superoxide via TORC pathway in the midgut of Rhodnius prolixus
Authors: Gandara Ana Caroline P. , Oliveira José Henrique M. , Nunes Rodrigo D. , Goncalves Renata L.S. , Dias Felipe A. , Hecht Fabio , Fernandes Denise C. , Genta Fernando A. , Laurindo Francisco R.M. , Oliveira Marcus F. , Oliveira Pedro L.
Published: March 2016

Sensing incoming nutrients is an important and critical event for intestinal cells to sustain life of the whole organism. The TORC is a major protein complex involved in monitoring the nutritional status and is activated by elevated amino acid concentrations. An important feature of haematophagy is that huge amounts of blood are ingested in a single meal, which results in the release of large quantities of amino acids, together with the haemoglobin prosthetic group, haem, which decomposes hydroperoxides and propagates oxygen-derived free radicals. Our previous studies demonstrated that reactive oxygen species (ROS) levels were diminished in the mitochondria and midgut of the Dengue fever mosquito, Aedes aegypti, immediately after a blood meal. We proposed that this mechanism serves to avoid oxidative damage that would otherwise be induced by haem following a blood meal. Studies also performed in mosquitoes have shown that blood or amino acids controls protein synthesis through TORC activation. It was already proposed, in different models, a link between ROS and TOR, however, little is known about TOR signalling in insect midgut nor about the involvement of ROS in this pathway. Here, we studied the effect of a blood meal on ROS production in the midgut of Rhodnius prolixus. We observed that blood meal amino acids decreased ROS levels in the R. prolixus midgut immediately after feeding, via lowering mitochondrial superoxide production and involving the amino acid-sensing TORC pathway.
Nitrogen mineralisation in soil after addition of wine distillery waste compost: laboratory and field evaluation
Authors: Requejo M. I. , Cartagena M. C. , Villena R. , Giraldo L. , Arce A. , Ribas F. , Cabello M. J. , Castellanos M. T.
Published: March 2016

The application of wastes from the wine-distillery industry as source of organic matter and nutrients could be a good option of agricultural management. This study is focused on soil nitrogen (N) mineralisation after addition of compost derived from this industry at different doses (7, 13 and 20 t ha–1). An aerobic soil incubation in controlled conditions was carried out to study N mineralisation from the soil-compost mixture as well as isolating the compost from the soil. The data were fitted to a non-linear regression obtaining low values of potentially mineralisable N (N0) and constants of mineralisation (k) (from 81 to 104 mg kg–1 and from 0.008 to 0.013 L day–1 for the soil-compost mixtures, and from 42 to 71 mg kg–1 and from 0.009 to 0.015 L day–1 for the increasing doses of compost) which indicates that it is a mature compost very resistant to mineralisation. Nitrogen mineralised (NM) in the field during two growing seasons (2011 and 2012) of a melon crop was calculated through a N balance, taking into account N inputs and outputs in the soil-plant system. NM in the unamended plots accounted to 31 kg ha–1 and 24 kg ha–1 in 2011 and 2012, respectively, and increased proportionally to the dose of compost applied until 113 kg ha–1 and 98 kg/ha in the consecutive years. The constants of mineralisation obtained in the laboratory were adjusted by field temperatures to predict NM in the field and a general overestimation was observed. The best estimates were obtained when considering the mixture of soil and compost, which reflects the important role of the soil to evaluate N mineralisation caused by the addition of organic wastes.