bluuebunny/crossref_metadata_2025 huggingface dataset:
Cisplatin-induced apoptosis in auditory, renal, and neuronal cells is associated with nitration and downregulation of LMO4
Authors: Rathinam R , Ghosh S , Neumann WL , Jamesdaniel S
Published: November 2015

Cytotoxic effects of cisplatin occur primarily through apoptosis. Though several pro- and anti-apoptotic signaling molecules have been identified to play an important role in mediating the ototoxic, nephrotoxic, and neurotoxic side effects of cisplatin, the underlying mechanism is yet to be fully characterized. We reported that nitration of LIM domain-only 4 (LMO4), a transcriptional regulator, facilitates cochlear apoptosis in cisplatin-induced ototoxicity. However, its role in cisplatin-mediated nephrotoxicity and neurotoxicity is poorly understood. Therefore, HK2 and SH-SY5Y cells were used along with UBOC1 cells, to investigate the perturbations of LMO4 in cisplatin-induced cytotoxicity, in renal, neuronal, and auditory cells, respectively. Cisplatin induced an increase in the expression of active caspase-3, indicating cellular apoptosis, and increased the nitration of proteins, 24 h post treatment. Immunostaining with anti-nitrotyrosine and anti-LMO4 indicated that nitrotyrosine co-localized with LMO4 protein in cisplatin-treated cells. Immunoblotting with anti-LMO4 indicated that cisplatin induced a decrease in LMO4 protein levels. However, a corresponding decrease in LMO4 gene levels was not observed. Inhibition of protein nitration with SRI110, a peroxynitrite decomposition catalyst, attenuated cisplatin-induced downregulation of LMO4. More importantly, overexpression of LMO4 mitigated the cytotoxic effects of cisplatin in UBOC1 cells while a dose-dependent decrease in LMO4 protein strongly correlated with cell viability in UBOC1, HK2, and SH-SY5Y cells. Collectively, these findings suggested a potential role of LMO4 in facilitating the cytotoxic effects of cisplatin in auditory, renal, and neuronal cells.
Planar-integrated single-crystalline perovskite photodetectors
Authors: Saidaminov Makhsud I. , Adinolfi Valerio , Comin Riccardo , Abdelhady Ahmed L. , Peng Wei , Dursun Ibrahim , Yuan Mingjian , Hoogland Sjoerd , Sargent Edward H. , Bakr Osman M.
Published: November 2015

Hybrid perovskites are promising semiconductors for optoelectronic applications. However, they suffer from morphological disorder that limits their optoelectronic properties and, ultimately, device performance. Recently, perovskite single crystals have been shown to overcome this problem and exhibit impressive improvements: low trap density, low intrinsic carrier concentration, high mobility, and long diffusion length that outperform perovskite-based thin films. These characteristics make the material ideal for realizing photodetection that is simultaneously fast and sensitive; unfortunately, these macroscopic single crystals cannot be grown on a planar substrate, curtailing their potential for optoelectronic integration. Here we produce large-area planar-integrated films made up of large perovskite single crystals. These crystalline films exhibit mobility and diffusion length comparable with those of single crystals. Using this technique, we produced a high-performance light detector showing high gain (above 104 electrons per photon) and high gain-bandwidth product (above 108 Hz) relative to other perovskite-based optical sensors.
Enhancing the linear flow of fine granules through the addition of elongated particles
Authors: Guo Zhiguo , Chen Xueli , Xu Yang , Liu Haifeng
Published: November 2015

Sandglasses have been used to record time for thousands of years because of their constant flow rates; however, they now are drawing attention for their substantial scientific importance and extensive industrial applications. The presence of elongated particles in a binary granular system is believed to result in undesired flow because their shape implies a larger resistance to flow. However, our experiments demonstrate that the addition of elongated particles can substantially reduce the flow fluctuation of fine granules and produce a stable linear flow similar to that in an hourglass. On the basis of experimental data and previous reports of flow dynamics, we observed that the linear flow is driven by the “needle particle effect,” including flow orientation, reduced agglomeration and local perturbation. This phenomenon is observed in several binary granular systems, including fine granules and secondary elongated particles, which demonstrates that our simple method can be widely applied to the accurate measurement of granular flows in industry.
The role of H4 flagella in Escherichia coli ST131 virulence
Authors: Kakkanat Asha , Totsika Makrina , Schaale Kolja , Duell Benjamin L. , Lo Alvin W. , Phan Minh-Duy , Moriel Danilo G. , Beatson Scott A. , Sweet Matthew J. , Ulett Glen C. , Schembri Mark A.
Published: November 2015

Escherichia coli sequence type 131 (ST131) is a globally dominant multidrug resistant clone associated with urinary tract and bloodstream infections. Most ST131 strains exhibit resistance to multiple antibiotics and cause infections associated with limited treatment options. The largest sub-clonal ST131 lineage is resistant to fluoroquinolones, contains the type 1 fimbriae fimH30 allele and expresses an H4 flagella antigen. Flagella are motility organelles that contribute to UPEC colonisation of the upper urinary tract. In this study, we examined the specific role of H4 flagella in ST131 motility and interaction with host epithelial and immune cells. We show that the majority of H4-positive ST131 strains are motile and are enriched for flagella expression during static pellicle growth. We also tested the role of H4 flagella in ST131 through the construction of specific mutants, over-expression strains and isogenic mutants that expressed alternative H1 and H7 flagellar subtypes. Overall, our results revealed that H4, H1 and H7 flagella possess conserved phenotypes with regards to motility, epithelial cell adhesion, invasion and uptake by macrophages. In contrast, H4 flagella trigger enhanced induction of the anti-inflammatory cytokine IL-10 compared to H1 and H7 flagella, a property that may contribute to ST131 fitness in the urinary tract.
Tears of wine: new insights on an old phenomenon
Authors: Venerus David C. , Nieto Simavilla David
Published: November 2015

Anyone who has enjoyed a glass of wine has undoubtedly noticed the regular pattern of liquid beads that fall along the inside of the glass, or ‘tears of wine.’ The phenomenon is the result of a flow against gravity along the liquid film on the glass, which is induced by an interfacial tension gradient. It is generally accepted that the interfacial tension gradient is due to a composition gradient resulting from the evaporation of ethanol. We re-examine the tears of wine phenomenon and investigate the importance of thermal effects, which previously have been ignored. Using a novel experiment and simple model we find that evaporative cooling contributes significantly to the flow responsible for wine tears and that this phenomenon occurs primarily because of the thermodynamic behavior of ethanol-water mixtures. Also, the regular pattern of tear formation is identified as a well-known hydrodynamic instability.
Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism
Authors: Maekawa Motoko , Iwayama Yoshimi , Ohnishi Tetsuo , Toyoshima Manabu , Shimamoto Chie , Hisano Yasuko , Toyota Tomoko , Balan Shabeesh , Matsuzaki Hideo , Iwata Yasuhide , Takagai Shu , Yamada Kohei , Ota Motonori , Fukuchi Satoshi , Okada Yohei , Akamatsu Wado , Tsujii Masatsugu , Kojima Nobuhiko , Owada Yuji , Okano Hideyuki , Mori Norio , Yoshikawa Takeo
Published: November 2015

The solute carrier 27A (SLC27A) gene family encodes fatty acid transport proteins (FATPs) and includes 6 members. During fetal and postnatal periods of development, the growing brain requires a reliable supply of fatty acids. Because autism spectrum disorders (ASD) are now recognized as disorders caused by impaired early brain development, it is possible that functional abnormalities ofSLC27Agenes may contribute to the pathogenesis of ASD. Here, we confirmed the expression ofSLC27A3andSLC27A4in human neural stem cells derived from human induced pluripotent stem cells, which suggested their involvement in the developmental stage of the central nervous system. Additionally, we resequenced theSLC27A3andSLC27A4genes using 267 ASD patient and 1140 control samples and detected 47 (44 novel and 29 nonsynonymous) and 30 (17 novel and 14 nonsynonymous) variants for theSLC27A3andSLC27A4, respectively, revealing that they are highly polymorphic with multiple rare variants. The SLC27A4 Ser209 allele was more frequently represented in ASD samples. Furthermore, we showed that a SLC27A4 Ser209 mutant resulted in significantly higher fluorescently-labeled fatty acid uptake into bEnd3 cells, a mouse brain capillary-derived endothelial cell line, compared with SLC27A4 Gly209, suggesting that the functional change may contribute to ASD pathophysiology.
Generating multi-atom entangled W states via light-matter interface based fusion mechanism
Authors: Zang Xue-Ping , Yang Ming , Ozaydin Fatih , Song Wei , Cao Zhuo-Liang
Published: November 2015

W state is a key resource in quantum communication. Fusion technology has been proven to be a good candidate for preparing a large-size W state from two or more small-size W states in linear optical system. It is of great importance to study how to fuse W states via light-matter interface. Here we show that it is possible to prepare large-size W-state networks using a fusion mechanism in cavity QED system. The detuned interaction between three atoms and a vacuum cavity mode constitute the main fusion mechanism, based on which two or three small-size atomic W states can be fused into a larger-size W state. If no excitation is detected from those three atoms, the remaining atoms are still in the product of two or three new W states, which can be re-fused. The complicated Fredkin gate used in the previous fusion schemes is avoided here. W states of size 2 can be fused as well. The feasibility analysis shows that our fusion processes maybe implementable with the current technology. Our results demonstrate how the light-matter interaction based fusion mechanism can be realized and may become the starting point for the fusion of multipartite entanglement in cavity QED system.
Impact of Visual Impairment and Eye diseases on Mortality: the Singapore Malay Eye Study (SiMES)
Authors: Siantar Rosalynn Grace , Cheng Ching-Yu , Gemmy Cheung Chui Ming , Lamoureux Ecosse L. , Ong Peng Guan , Chow Khuan Yew , Mitchell Paul , Aung Tin , Wong Tien-Yin , Cheung Carol Y.
Published: November 2015

We investigated the relationship of visual impairment (VI) and age-related eye diseases with mortality in a prospective, population-based cohort study of 3,280 Malay adults aged 40–80 years between 2004–2006. Participants underwent a full ophthalmic examination and standardized lens and fundus photographic grading. Visual acuity was measured using logMAR chart. VI was defined as presenting (PVA) and best-corrected (BCVA) visual acuity worse than 0.30 logMAR in the better-seeing eye. Participants were linked with mortality records until 2012. During follow-up (median 7.24 years), 398 (12.2%) persons died. In Cox proportional-hazards models adjusting for relevant factors, participants with VI (PVA) had higher all-cause mortality (hazard ratio[HR], 1.57; 95% confidence interval[CI], 1.25–1.96) and cardiovascular (CVD) mortality (HR 1.75; 95% CI, 1.24–2.49) than participants without. Diabetic retinopathy (DR) was associated with increased all-cause (HR 1.70; 95% CI, 1.25–2.36) and CVD mortality (HR 1.57; 95% CI, 1.05–2.43). Retinal vein occlusion (RVO) was associated with increased CVD mortality (HR 3.14; 95% CI, 1.26–7.73). No significant associations were observed between cataract, glaucoma and age-related macular degeneration with mortality. We conclude that persons with VI were more likely to die than persons without. DR and RVO are markers of CVD mortality.
Biological and immunotoxicity evaluation of antimicrobial peptide-loaded coatings using a layer-by-layer process on titanium
Authors: Shi Jue , Liu Yu , Wang Ying , Zhang Jing , Zhao Shifang , Yang Guoli
Published: November 2015

The prevention and control of peri-implantitis is a challenge in dental implant surgery. Dental implants with sustained antimicrobial coating are an ideal way of preventing peri-implantitis. This study reports development of a non- immunotoxicity multilayered coating on a titanium surface that had sustained antimicrobial activity and limited early biofilm formation. In this study, the broad spectrum AMP, Tet213, was linked to collagen IV through sulfo-SMPB and has been renamed as AMPCol. The multilayer AMPCol coatings were assembled on smooth titanium surfaces using a LBL technique. Using XPS, AFM, contact angle analysis and QCM, layer-by-layer accumulation of coating thickness was measured and increased surface wetting compared to controls was confirmed. Non-cytotoxicity to HaCaT and low erythrocyte hemolysis by the AMPCol coatings was observed.In vivoimmunotoxicity assays showed IP administration of AMPCol did not effect serum immunoglobulin levels. This coating with controlled release of AMP decreased the growth of both a Gram-positive aerobe (Staphylococcus aureus) and a Gram-negative anaerobe (Porphyromonas gingivalis) up to one month. EarlyS. aureusbiofilm formation was inhibited by the coating. The excellent long-term sustained antimicrobial activity of this multilayer coating is a potential method for preventing peri-implantitis through coated on the neck of implants before surgery.
Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1
Authors: Wu Qingsi , Nie Jia , Gao Yayi , Xu Peng , Sun Qijuan , Yang Jing , Han Lei , Chen Zuojia , Wang Xiuwen , Lv Ling , Tsun Andy , Shen Jijia , Li Bin
Published: November 2015

T helper 17 (Th17) cells not only play critical roles in protecting against bacterial and fungal infections but are also involved in the pathogenesis of autoimmune diseases. The retinoic acid-related orphan receptor (RORγt) is a key transcription factor involved in Th17 cell differentiation through direct transcriptional activation of interleukin 17(A) (IL-17). How RORγt itself is regulated remains unclear. Here, we report that p300, which has histone acetyltransferase (HAT) activity, interacts with and acetylates RORγt at its K81 residue. Knockdown of p300 downregulates RORγt protein and RORγt-mediated gene expression in Th17 cells. In addition, p300 can promote RORγt-mediated transcriptional activation. Interestingly, the histone deacetylase (HDAC) HDAC1 can also interact with RORγt and reduce its acetylation level. In summary, our data reveal previously unappreciated posttranslational regulation of RORγt, uncovering the underlying mechanism by which the histone acetyltransferase p300 and the histone deacetylase HDAC1 reciprocally regulate the RORγt-mediated transcriptional activation of IL-17.
Spectroscopic characterization of charge carrier anisotropic motion in twisted few-layer graphene
Authors: Kandyba Viktor , Yablonskikh Mikhail , Barinov Alexei
Published: November 2015

Graphene, a layer of carbon atoms in a honeycomb lattice, captures enormous interest as probably the most promising component of future electronics thanks to its mechanical robustness, flexibility and unique charge carrier quasiparticles propagating like massless high energy Dirac fermions. If several graphene layers form a stack, the interaction between them is, on the one hand, weak, allowing realization of various registries between the layers and, on the other hand, strong enough for a wide range tuning of the electronic properties. Here we grow few layer graphene with various number of layers and twist configurations and address the electronic properties of individual atomic layers in single microscopic domains using angle-resolved photoelectron spectromicroscopy. The dependence of the interlayer coupling on the twist angle is analyzed and, in the domains with tri-layers and more, if different rotations are present, the electrons in weaker coupled adjacent layers are shown to have different properties manifested by coexisting van Hove singularities, moiré superlattices with corresponding superlattice Dirac points and charge carrier group velocity renormalizations. Moreover, pronounced anisotropy in the charge carrier motion, opening a possibility to transform strongly coupled graphene bilayers into quasi one-dimensional conductors, is observed.
The genetic regulatory network centered on Pto-Wuschela and its targets involved in wood formation revealed by association studies
Authors: Yang Xiaohui , Wei Zunzheng , Du Qingzhang , Chen Jinhui , Wang Qingshi , Quan Mingyang , Song Yuepeng , Xie Jianbo , Zhang Deqiang
Published: November 2015

Transcription factors (TFs) regulate gene expression and can strongly affect phenotypes. However, few studies have examined TF variants and TF interactions with their targets in plants. Here, we used genetic association in 435 unrelated individuals ofPopulus tomentosato explore the variants inPto-Wuschelaand its targets to decipher the genetic regulatory network ofPto-Wuschela. Our bioinformatics and co-expression analysis identified 53 genes with the motif TCACGTGA as putative targets ofPto-Wuschela. Single-marker association analysis showed thatPto-Wuschelawas associated with wood properties, which is in agreement with the observation that it has higher expression in stem vascular tissues inPopulus. Also, SNPs in the 53 targets were associated with growth or wood properties under additive or dominance effects, suggesting these genes andPto-Wuschelamay act in the same genetic pathways that affect variation in these quantitative traits. Epistasis analysis indicated that 75.5% of these genes directly or indirectly interactedPto-Wuschela, revealing the coordinated genetic regulatory network formed byPto-Wuschelaand its targets. Thus, our study provides an alternative method for dissection of the interactions between a TF and its targets, which will strength our understanding of the regulatory roles of TFs in complex traits in plants.
The Directional Observation of Highly Dynamic Membrane Tubule Formation Induced by Engulfed Liposomes
Authors: Zhang Xiaoming , Dai Luru , Wang Anhe , Wölk Christian , Dobner Bodo , Brezesinski Gerald , Tang Yunqing , Wang Xianyou , Li Junbai
Published: November 2015

Highly dynamic tubular structures in cells are responsible for exchanges between organelles. Compared with bacterial invasion, the most affordable and least toxic lipids were found in this study to be gentle and safe exogenous stimuli for the triggering of membrane tubules. A specific lipid system was internalized by NIH3T3 cells. Following cellular uptake, the constructed liposomes traveled towards the nucleus in aggregations and were gradually distributed into moving vesicles and tubules in the cytosol. The triggered tubules proceeded, retreated or fluctuated along the cytoskeleton and were highly dynamic, moving quickly (up to several microns per second) and breaking and fusing frequently. These elongated tubules could also fuse with one another, giving rise to polygonal membrane networks. These lipid systems, with the novel property of accelerating intracellular transport, provide a new paradigm for investigating cellular dynamics.
Location-dependent sensing of nitric oxide and calcium ions in living rat kidney using an amperometric/potentiometric dual microsensor
Authors: Kim Yee Seul , Ha Yejin , Sim Jungeun , Suh Minah , Lee Youngmi
Published: November 2015

Location-dependent NO/Ca2+levels of a rat kidney are measured simultaneously using a dual amperometric/potentiometric NO/Ca2+microsensor.
Dual selective iron chelating probes with a potential to monitor mitochondrial labile iron pools
Authors: Abbate Vincenzo , Reelfs Olivier , Kong Xiaole , Pourzand Charareh , Hider Robert C.
Published: November 2015

Mitochondria-targeted peptides incorporating dual fluorescent and selective iron chelators have been designed as novel biosensors for the mitochondrial labile iron pool.
Synthesis of highly white-fluorescent Cu–Ga–S quantum dots for solid-state lighting devices
Authors: Jo Dae-Yeon , Yang Heesun
Published: November 2015

Highly efficient, white-emitting Cu–Ga–S quantum dots are synthesized and applied as down-converters for white lighting device fabrication.
Synthesis, structure and bonding of hexaphenyl thorium(iv): observation of a non-octahedral structure
Authors: Pedrick Elizabeth A. , Hrobárik Peter , Seaman Lani A. , Wu Guang , Hayton Trevor W.
Published: November 2015

[Li(THF)(12-crown-4)]2[Th(C6H5)6] features a non-octahedral coordination geometry about the Th ion. This structural distortion is driven by the presence of anagostic ortho C–H⋯Th interactions, which arise from σ(C–H) → Th(5f) donation.
Rearrangement of {α-P2W15} to {PW6} moieties during the assembly of transition-metal-linked polyoxometalate clusters
Authors: Martin-Sabi Mercè , Winter Ross Stuart , Lydon Claire , Cameron Jamie M. , Long De-Liang , Cronin Leroy
Published: November 2015

Formation of a series of polyoxometalates showing the unprecedented transformation of a Dawson lacunae into a Keggin lacunae.
Turning the heat on conjugated polyelectrolytes: an off–on ratiometric nanothermometer
Authors: Darwish Ghinwa H. , Koubeissi Ali , Shoker Tharallah , Abou Shaheen Samir , Karam Pierre
Published: November 2015

A ratiometric single component nanothermometer fluorescent probe.
Hydrogen-bonding networks of purine derivatives and their bilayers for guest intercalation
Authors: Jang Yoona , Yoo Seo Yeon , Gu Hye Rin , Lee Yu Jin , Cha Young Shin , You Laekyeong , Noh Kyungkyou , Kim Jaheon
Published: November 2015

6-Chloro-9-propyl-purin-2-amine (pr-GCl) forms two-dimensional hydrogen-bonded networks which in turn stack via π–π interactions, leading to the formation of bilayers that can accommodate organic guest molecules.
Excited-state dynamics of guanosine in aqueous solution revealed by time-resolved photoelectron spectroscopy: experiment and theory
Authors: Buchner Franziska , Heggen Berit , Ritze Hans-Hermann , Thiel Walter , Lübcke Andrea
Published: November 2015

Time-resolved photoelectron spectroscopy is performed on aqueous guanosine solution to study its excited-state relaxation dynamics.
Nanoparticle induced miscibility in LCST polymer blends: critically assessing the enthalpic and entropic effects
Authors: Xavier Priti , Rao Praveen , Bose Suryasarathi
Published: November 2015

The use of polymer blends widened the possibility of creating materials with multilayered architectures.
Porous nanoarchitectures of spinel-type transition metal oxides for electrochemical energy storage systems
Authors: Park Min-Sik , Kim Jeonghun , Kim Ki Jae , Lee Jong-Won , Kim Jung Ho , Yamauchi Yusuke
Published: November 2015

Transition metal oxides possessing two kinds of metals (denoted as AxB3−xO4, which is generally defined as a spinel structure; A, B = Co, Ni, Zn, Mn, Fe,etc.), with stoichiometric or even non-stoichiometric compositions, have recently attracted great interest in electrochemical energy storage systems (ESSs).
Effect of salts on the solubility of ionic liquids in water: experimental and electrolyte Perturbed-Chain Statistical Associating Fluid Theory
Authors: Neves Catarina M. S. S. , Held Christoph , Mohammad Sultan , Schleinitz Miko , Coutinho João A. P. , Freire Mara G.
Published: November 2015

New experimental data for the solubility of ILs in aqueous salt solutions are provided while ePC-SAFT can be used in a totally predictive approach to describe the liquid–liquid phase behavior.
Suspensions of carbon nanofibers in organic medium: rheo-electrical properties
Authors: Youssry Mohamed , Guyomard Dominique , Lestriez Bernard
Published: November 2015

The nonaqueous suspensions of carbon nanofibers (CNFs) in 1 M lithium bis(trifluoromethanesulfonaimide) in propylene carbonate electrolyte reveal unique structural evolution and shear-induced transition due to the high aspect ratio.
Low bandgap semiconducting polymers for polymeric photovoltaics
Authors: Liu Chang , Wang Kai , Gong Xiong , Heeger Alan J.
Published: November 2015

This review highlights the design rules for low bandgap semiconducting polymers, with the overview of their applications in polymer solar cells and polymer photodetectors.
Lewis acidic zeolite Beta catalyst for the Meerwein–Ponndorf–Verley reduction of furfural
Authors: Koehle Maura , Lobo Raul F.
Published: November 2015

Tin-, zirconium- and hafnium-containing siliceous Beta zeolite were investigated in the Meerwein–Ponndorf–Verley reduction of furfural under continuous flow conditions.
Low-temperature nitric oxide reduction over silver-substituted cobalt oxide spinels
Authors: Salker A. V. , Fal Desai M. S.
Published: November 2015

Catalytic reduction of NO by CO is performed over novel silver-substituted cobalt oxide nano-sized spinels, prepared via a citric acid-assisted sol–gel method. The catalysts are characterized by XRD, TEM, BET surface area measurements and CO chemisorption studies.
Visible-light-induced photocatalysis and peroxymonosulfate activation over ZnFe2O4 fine nanoparticles for degradation of Orange II
Authors: Zhu Kaixin , Wang Junhu , Wang Yanjie , Jin Changzi , Ganeshraja Ayyakannu Sundaram
Published: November 2015

The coupling effect of photocatalysis and PMS activation remarkably manifested in the eco-friendly ZnFe2O4/PMS/vis system for Orange II degradation.
Activation of molecular oxygen by a molybdenum complex for catalytic oxidation
Authors: Dupé Antoine , Judmaier Martina E. , Belaj Ferdinand , Zangger Klaus , Mösch-Zanetti Nadia C.
Published: November 2015

Activation of molecular oxygen by a Mo(iv) complex yields the corresponding oxo–peroxo complex, which is able to catalyze oxygen atom transfer to a model substrate by transferring both oxygen atoms of the peroxo group.
Fabrication and characterization of a highly sensitive hydroquinone chemical sensor based on iron-doped ZnO nanorods
Authors: Umar Ahmad , Al-Hajry Ali , Ahmad Rafiq , Ansari S. G. , Al-Assiri Mohammed Sultan , Algarni Hamed
Published: November 2015

Herein, we report the development of a simple and highly sensitive hydroquinone (HQ) chemical sensor based on an electrochemically activated iron-doped zinc oxide nanorod modified screen-printed electrode.
Hydrophosphination reactions with transition metal ferrocenylphosphine complexes
Authors: Pritzwald-Stegmann Julian Rodger Frederic , Lönnecke Peter , Hey-Hawkins Evamarie
Published: November 2015

The group 6 metal mono-, bis- and tris-ferrocenylphosphine complexes [M(CO)5(PH2Fc)],cis-[M(CO)4(PH2Fc)2] andfac-[M(CO)3(PH2Fc)3] (M = Cr, Mo, W; Fc = Fe(η5-C5H4)(η5-C5H5)) were prepared and fully characterised. The coordinated FcPH2ligand of [W(CO)5(PH2Fc)] undergoes hydrophosphination with alkene substrates bearing EWGs, yielding the corresponding secondary phosphine complexes.
A Dy2 single-molecule magnet with benzoate anions and phenol-O− bridging groups
Authors: Ke Hongshan , Zhang Sheng , Li Xin , Wei Qing , Xie Gang , Wang Wenyuan , Chen Sanping
Published: November 2015

A Dy2 single-molecule magnet, namely [Dy2(H3L)2(PhCOO)4]·4H2O (1), was obtained from the reaction of Dy(PhCOO)3 with 1,5-bis(2-hydroxy-3-methoxybenzylidene)carbonohydrazide (H4L).
Modification of both d33and TCin a potassium–sodium niobate ternary system
Authors: Wu Bo , Wu Jiagang , Xiao Dingquan , Zhu Jianguo
Published: November 2015

In this work, we simultaneously achieved a giantd33and a highTCin a lead-free piezoelectric ternary system of (1 −x−y)K0.48Na0.52NbO3–xBiFeO3–yBi0.5Na0.5ZrO3{(1 −x−y)KNN–xBF–yBNZ}.
Synthesis of the first metal-free phosphanylphosphonate and its use in the “phospha–Wittig–Horner” reaction
Authors: Esfandiarfard Keyhan , Arkhypchuk Anna I. , Orthaber Andreas , Ott Sascha
Published: November 2015

The synthesis of the first phophanylphosphonate, Mes*PH–PO(OEt)2 (2-H), in which the P(iii) centre is not coordinated by a metal fragment is reported.
Versatility of the ionic assembling method to design highly luminescent PMMA nanocomposites containing [M6Qi8La6]n−octahedral nano-building blocks
Authors: Amela-Cortes Maria , Molard Yann , Paofai Serge , Desert Anthony , Duvail Jean-Luc , Naumov Nikolay G. , Cordier Stéphane
Published: November 2015

Strongly luminescent hybrid nanocomposites were designed by integratingviaan ionic technique high content of different transition metal clusters.
Hierarchical structures composed of MnCo2O4@MnO2 core–shell nanowire arrays with enhanced supercapacitor properties
Authors: Zheng Xiaoting , Ye Yunlong , Yang Qian , Geng Baoyou , Zhang Xiaojun
Published: November 2015

In this paper, hierarchical MnCo2O4@MnO2 core–shell nanowire arrays (MnCo2O4@MnO2 NWAs) with mesoporous and large surface area are synthesized on 3D nickel foam via a facile, two-step hydrothermal approach without any adscititious surfactant and binder.
Two RhIII-substituted polyoxoniobates and their base-induced transformation: [H2RhNb9O28]6− and [Rh2(OH)4Nb10O30]8−
Authors: Son Jung-Ho , Casey Willam H.
Published: November 2015

Two new rhodium-substituted polyoxoniobates, [H2RhNb9O28]6− (RhNb9) and [Rh2(OH)4Nb10O30]8− (Rh2Nb10) are reported.
Reactions of alkynes with cis-RuCl2(dppm)2: exploring the interplay of vinylidene, alkynyl and η3-butenynyl complexes
Authors: Eaves Samantha G. , Yufit Dmitry S. , Skelton Brian W. , Lynam Jason M. , Low Paul J.
Published: November 2015

The course of reactions between cis-RuCl2(dppm)2 and terminal alkynes is shown to depend markedly on the electronic character of the alkyne reagent.
Dielectric response and anhydrous proton conductivity in a chiral framework containing a non-polar molecular rotor
Authors: Yu Shan-Shan , Liu Shao-Xian , Duan Hai-Bao
Published: November 2015

A chiral 3D framework containing a nonpolar rotor shows two dielectric anomalies and can serve as a proton conductor under high-temperature and anhydrous conditions.
Homogeneous and heterogenised masked N-heterocyclic carbenes for bio-based cyclic carbonate synthesis
Authors: Stewart Joseph A. , Drexel Roland , Arstad Bjørnar , Reubsaet Erik , Weckhuysen Bert M. , Bruijnincx Pieter C. A.
Published: November 2015

Substrate scope (including crude glycerol), influence of organocatalyst structure, mechanistic aspects and catalyst heterogenisation are reported.
Combining bio- and chemo-catalysis for the conversion of bio-renewable alcohols: homogeneous iridium catalysed hydrogen transfer initiated dehydration of 1,3-propanediol to aldehydes
Authors: Wang Yue-Ming , Lorenzini Fabio , Rebros Martin , Saunders Graham C. , Marr Andrew C.
Published: November 2015

The hydrogen transfer initiated dehydration of 1,3-propanadiol to propionaldehyde, catalysed by a highly recyclable, air and water stable, soluble Ir(iii) complex, in an ionic liquid, was demonstrated.
Speciation of chromium by dispersive liquid–liquid microextraction followed by laser-induced breakdown spectrometry detection (DLLME–LIBS)
Authors: Gaubeur Ivanise , Aguirre Miguel Ángel , Kovachev Nikolay , Hidalgo Montserrat , Canals Antonio
Published: November 2015

Combination of dispersive liquid–liquid microextraction with laser-induced breakdown spectrometry for simultaneous pre-concentration, speciation and detection of Cr.
3D cardiac μtissues within a microfluidic device with real-time contractile stress readout
Authors: Aung Aereas , Bhullar Ivneet Singh , Theprungsirikul Jomkuan , Davey Shruti Krishna , Lim Han Liang , Chiu Yu-Jui , Ma Xuanyi , Dewan Sukriti , Lo Yu-Hwa , McCulloch Andrew , Varghese Shyni
Published: November 2015

We present the development of three-dimensional (3D) cardiac microtissues within a microfluidic device with the ability to quantify real-time contractile stress measurementsin situ.
Digital droplet PCR on disk
Authors: Schuler Friedrich , Trotter Martin , Geltman Marcel , Schwemmer Frank , Wadle Simon , Domínguez-Garrido Elena , López María , Cervera-Acedo Cristina , Santibáñez Paula , von Stetten Felix , Zengerle Roland , Paust Nils
Published: November 2015

An integrated digital droplet PCR system is presented that enables droplet generation, PCR amplification, and readout within a single reaction chamber on a centrifugal microfluidic LabDisk.
A surface acoustic wave biosensor for interrogation of single tumour cells in microcavities
Authors: Senveli Sukru U. , Ao Zheng , Rawal Siddarth , Datar Ram H. , Cote Richard J. , Tigli Onur
Published: November 2015

Tumour cells are acoustically interrogated using Rayleigh type SAW devices where an embedded microcavity facilitates direct interaction between the cells and the surface waves.
Photodynamic assembly of nanoparticles towards designable patterning
Authors: Wang Huan , Zhang Yong-Lai , Xia Hong , Chen Qi-Dai , Lee Kwang-Sup , Sun Hong-Bo
Published: November 2015

We summarize the recent development in photodynamic assembly (PDA) technology for the designable patterning of nanoparticles (NPs). The fundamentals of PDA that resort to optical trapping (OT) and typical processes are reviewed.
Electromechanical coupling and design considerations in single-layer MoS2 suspended-channel transistors and resonators
Authors: Yang Rui , Islam Arnob , Feng Philip X.-L.
Published: November 2015

We describe systematic investigation of electromechanical coupling effects in suspended single-layer MoS2, as suspended-channel field-effect transistors and vibrating-channel nanoelectromechanical resonators.
Field-directed assembly of nanowires: identifying directors, disruptors and indices to maximize the device yield
Authors: Sam Mahshid , Moghimian Nima , Bhiladvala Rustom B.
Published: November 2015

A systematic framework for field-directed assembly of nanowires is introduced, based on identification of director and disruptor forces. Using this, we demonstrate the realization of 94% pre-clamped yield.
Hydrolytically degradable, dendritic polyglycerol sulfate based injectable hydrogels using strain promoted azide–alkyne cycloaddition reaction
Authors: Dey Pradip , Hemmati-Sadeghi Shabnam , Haag Rainer
Published: November 2015

An anionic degradable hydrogel based on a heparin mimetic polymer was prepared using PEG-PCL-DIC as a crosslinker.
The large electrochemical capacitance of nitrogen-doped mesoporous carbon derived from egg white by using a ZnO template
Authors: Chen Jiucun , Liu Yinqin , Li Wenjun , Yang Huan , Xu Liqun
Published: November 2015

We used ZnO nanoparticles as a hard template and egg white as a precursor to successfully synthesize nitrogen-doped mesoporous carbon materials and the as-prepared material was further used as an electrode material for supercapacitor applications.
Tailoring the optical properties of ZnO nano-layers and their effect on in vitro biocompatibility
Authors: Rogé Vincent , Georgantzopoulou Anastasia , Mehennaoui Kahina , Fechete Ioana , Garin François , Dinia Aziz , Gutleb Arno C. , Lenoble Damien
Published: November 2015

This paper highlights the use of Al2O3 and SnO2 films as protecting layers to tailor the optical properties and biocompatibility of ZnO nano-films.
CL-20 hosted in graphene foam as a high energy material with low sensitivity
Authors: Li Zhimin , Wang Yu , Zhang Yanqiang , Liu Long , Zhang Suojiang
Published: November 2015

A 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20)/graphene foam (GF) composite with a guest–host architecture was prepared as a high energy material with low sensitivity.
Synthesis of β-nitrostyrenes in the presence of sulfated zirconia and secondary amines
Authors: González-Olvera R. , Vergara-Arenas B. I. , Negrón-Silva G. E. , Angeles-Beltrán D. , Lomas-Romero L. , Gutiérrez-Carrillo A. , Lara V. H. , Morales-Serna J. A.
Published: November 2015

A simple and efficient protocol for the synthesis of β-nitrostyrenes has been achieved by the use of sulfated zirconia–secondary amine cooperative systems.
Effects of monovalent ions on membrane potential and permselectivity: evaluation of fixed charge density of polymer based zirconium aluminophosphate composite membrane
Authors: Imteyaz Shahla , Rafiuddin Rafiuddin
Published: November 2015

The composite of poly(vinyl chloride) (PVC) with zirconium aluminophosphate (ZrAlP) employed as additive was prepared by sol–gel method.
Anchoring ternary CuFePd nanocatalysts on reduced graphene oxide to improve the electrocatalytic activity for the methanol oxidation reaction
Authors: Zhang Xuan , Zhang Yi-Chi , Zhang Jia-Wei , Zhang Bei
Published: November 2015

A ternary CuFePd/rGO electrocatalyst was developed facilely, which exhibited improved performance compared to binary CuPd/rGO, FePd/rGO and Pd/rGO.
Size dependent catalytic activities of green synthesized gold nanoparticles and electro-catalytic oxidation of catechol on gold nanoparticles modified electrode
Authors: Ahmad Aftab , Wei Yun , Syed Fatima , Imran Muhammad , Khan Zia Ul Haq , Tahir Kamran , Khan Arif Ullah , Raza Muslim , Khan Qudratullah , Yuan Qipeng
Published: November 2015

A green and facile method for the synthesis of gold nanoparticles with efficient catalytic activity.
Photo-driven near-IR fluorescence switch: synthesis and spectroscopic investigation of squarine-spiropyran dyad
Authors: Doddi Siva , Ramakrishna Bheerappagari , Venkatesh Yeduru , Bangal Prakriti Ranjan
Published: November 2015

Novel NIR fluorescent dyad was synthesized using Squarine derivatives (SQ) and Spiropyran (SP) and characterized. Light driven reversible changes between two isomers of SP modulate the fluorescence of SQ leading to ON/OFF switching behaviors.
Poly(3,4-ethylenedioxythiophene)/nickel disulfide microspheres hybrid in energy storage and conversion cells
Authors: Mukkabla Radha , Deepa Melepurath , Srivastava Avanish Kumar
Published: November 2015

The redox pseudocapacitive response of a hybrid material made up of NiS2 microspheres embedded in a poly(3,4-ethylenedioxythiophene) or (PEDOT) layer is demonstrated for the first time.
Anaerobic co-digestion of municipal wastewater sludge with food waste with different fat, oil, and grease contents: study of reactor performance and extracellular polymeric substances
Authors: Xu Rui , Yang Zhaohui , Chen Ting , Zhao Lijun , Huang Jing , Xu Haiyin , Song Peipei , Li Min
Published: November 2015

The relationship between extracellular polymeric substances and microbial activity was investigated in three groups of fat, oil, and grease (FOG)-enhanced ACoD reactors.
Shape-dependent collective diffusion coefficient of multi-layers graphene nanopores
Authors: Wen Jia-le , Zheng Dong-qin , Zhong Wei-rong
Published: November 2015

Using non-equilibrium molecular dynamics, the particle transport in graphene membrane nanopores has been studied. It is suggested that the interfacial and intracrystalline resistance can suppress particle transport in nanopores.
Anthanthrene dye-sensitized solar cells: influence of the number of anchoring groups and substitution motif
Authors: Geng Yan , Yi Chenyi , Bircher Martin Peter , Decurtins Silvio , Cascella Michele , Grätzel Michael , Liu Shi-Xia
Published: November 2015

Four anthanthrene-based molecules were synthesized as sensitizers in dye-sensitized solar cells, leading to the best overall efficiency up to 5.3%.
Orientation-controlled BaTiO3 thin films fabricated by chemical solution deposition
Authors: Hosokura Tadasu , Ando Akira , Konoike Takehiro
Published: November 2015

We synthesized orientation-controlled (100), (110), and (111) BaTiO3 films by the CSD method and revealed the dielectric properties the films.
Convection associated with exclusion zone formation in colloidal suspensions
Authors: Musa Sami , Florea Daniel , Wyss Hans M. , Huyghe Jacques M.
Published: November 2015

Our experiments on exclusion-zone formation in colloidal suspensions indicate that in addition to diffusiophoresis of the particles, diffusioosmotic flows of the fluid play an important role and lead to double convective flow patterns.
Prediction of structures and properties of 2,4,6-triamino-1,3,5-triazine-1,3,5-trioxide (MTO) and 2,4,6-trinitro-1,3,5-triazine-1,3,5-trioxide (MTO3N) green energetic materials from DFT and ReaxFF molecular modeling
Authors: Naserifar Saber , Zybin Sergey , Ye Cai-Chao , Goddard III William A.
Published: November 2015

Structures and properties of new green energetic materials: I. MTO (P21): ρ=1.92 g cm-3, ΔHrxn = 1036 kcal kg-1 II. MTO3N (P21/c): ρ=2.1 g cm-3, ΔHrxn =1412 kcal kg-1.
A novel phosphorylation site at Ser130 adjacent to the pseudosubstrate domain contributes to the activation of protein kinase C-δ
Authors: Gong Jianli , Holewinski Ronald J. , Van Eyk Jennifer E. , Steinberg Susan F.
Published: November 2015

Protein kinase C-δ (PKCδ) is a signalling kinase that regulates many cellular responses. Although most studies focus on allosteric mechanisms that activate PKCδ at membranes, PKCδ also is controlled via multi-site phosphorylation [Gong et al. (2015) Mol. Cell. Biol. 35, 1727–1740]. The present study uses MS-based methods to identify PKCδ phosphorylation at Thr50 and Ser645 (in resting and PMA-treated cardiomyocytes) as well as Thr37, Thr38, Ser130, Thr164, Thr211, Thr215, Ser218, Thr295, Ser299 and Thr656 (as sites that increase with PMA). We focused on the consequences of phosphorylation at Ser130 and Thr141 (sites just N-terminal to the pseudosubstrate domain). We show that S130D and T141E substitutions co-operate to increase PKCδ’s basal lipid-independent activity and that Ser130/Thr141 di-phosphorylation influences PKCδ’s substrate specificity. We recently reported that PKCδ preferentially phosphorylates substrates with a phosphoacceptor serine residue and that this is due to constitutive phosphorylation at Ser357, an ATP-positioning G-loop site that limits PKCδ’s threonine kinase activity [Gong et al. (2015) Mol. Cell. Biol. 35, 1727–1740]. The present study shows that S130D and T141E substitutions increase PKCδ’s threonine kinase activity indirectly by decreasing G loop phosphorylation at Ser357. A S130F substitution [that mimics a S130F single-nt polymorphism (SNP) identified in some human populations] also increases PKCδ’s maximal lipid-dependent catalytic activity and confers threonine kinase activity. Finally, we show that Ser130/Thr141 phosphorylations relieve auto-inhibitory constraints that limit PKCδ’s activity and substrate specificity in a cell-based context. Since phosphorylation sites map to similar positions relative to the pseudosubstrate domains of other PKCs, our results suggest that phosphorylation in this region of the enzyme may constitute a general mechanism to control PKC isoform activity.
Histogram‐based calibration of capacitor mismatch in SAR ADCs
Authors: Swindlehurst Eric , Chiang Shiuh‐hua Wood
Published: November 2015

An all‐digital, histogram‐based calibration technique to correct capacitor mismatch in successive‐approximation register (SAR) ADCs is proposed. Using a windowing technique to detect non‐uniform code densities, the calibration recursively tunes the bit weights to correct capacitor errors. Simulations of an 8‐bit SAR ADC suffering from capacitor mismatch show significant improvements in differential non‐linearity, integral non‐linearity, and signal‐to‐noise‐and‐distortion ratio after employing the proposed calibration.
Hybrid fuzzy anti‐islanding for grid‐connected and islanding operation in distributed generation systems
Authors: Aguiar Cassius Rossi , Fuzato Guilherme , Bastos Renan Fernandes , Gonçalves Amilcar F. Querubini , Machado Ricardo Quadros
Published: November 2015

This study proposes a method for islanding detection in distributed generation systems, namely, hybrid fuzzy positive feedback (PF). The aim is to reduce the injection of disturbances during the grid‐connected operation from the anti‐islanding methods, particularly at the instant of load connection and, do not require adjustment of the PF gain and frequency filters. This method is designed from fuzzy inference rules and the frequency and voltage inputs are also taken into account in the design procedure. Since the classical active methods do not identify if the voltage variation arises from the islanding condition or from a power quality issue in the grid, the fuzzy PF enables the proposed methods to differentiate the islanding condition from other grid events. In contrast to classical methods that have a fixed PF gain, a dynamic fuzzy PF gain is obtained by means of the fuzzy inference rules. The classical active technique is compared with the proposed approach in terms of detection time and injected disturbances during the grid‐connected operation. The simulation and experimental results are presented to demonstrate the effectiveness of the proposed approach.
„Psychische Gesundheit bei erwachsenen Menschen mit intellektueller Behinderung. Schutz- und Risikofaktoren in Bezug auf Depression und Angststörung“ – eine Querschnittstudie
Authors: Schmückle D. , Schmolz G. , Lindert J.
Published: November 2015

Hintergrund: Psychische Gesundheit bei Menschen mit intellektueller Behinderung wurde bisher nur wenig untersucht. Ziel dieser Studie ist es, Daten zu depressiven Beschwerden und pathologische Angstausprägungen bei Menschen mit intellektueller Behinderung zur Verfügung zu stellen.

Methode: In einer Querschnittstudie wurden Männer und Frauen mit intellektueller Behinderung (18–65 Jahre) mit einem standardisierten Erfassungsinstrument mit 2 Teilen befragt (Teil 1: Variablen „Wohnsituation“, „Selbstbestimmungsmöglichkeiten“, „Gewalterfahrungen“, Teil 2: Variablen „Depression“ und „Angststörungen“ mithilfe des Patient-Health-Questionaire-4 erhoben). Die Daten wurden univariat und bivariat ausgewertet.

Ergebnisse: 44 Personen (Response rate=45%) nahmen an der Studie teil (59% Männer, 41% Frauen). Insgesamt haben 20% (N=9) aller Teilnehmenden dieser Studie einen erhöhten PHQ-2 Score, der auf stärkere depressive Beschwerden hinweist. 18% (N=8) der Probanden weisen einen erhöhten GAD-2 Score auf, der als Indikator für pathologische Angstausprägungen gewertet werden kann. Risikofaktoren für depressive Störungen sind ein „erhöhter Behinderungsgrad“ (RR=11,8) „Wohnen bei den Eltern“ (RR=6,7), „eingeschränkte Selbstbestimmungsmöglichkeiten“ (RR=6,2) und „Angst vor neuen Situationen“ (RR=5,0). Gewalterfahrungen sind ein Risikofaktor (RR=13,3) in Bezug auf pathologische Angstausprägungen.

Schlussfolgerung: Die Studie ist aufgrund der besonderen methodischen Herausforderungen bei dieser Zielgruppe sehr klein. Dennoch gibt diese Studie als eine der ersten in Deutschland Hinweise auf Faktoren, die mit Depressionen und Angst bei Menschen mit intellektueller Behinderung assoziiert sind. Die Assoziation von Gewalterfahrungen und Angst bei Menschen mit intellektueller Behinderung ist eine wichtige Herausforderung für Public Health.
Entscheidungsfaktoren und Informationsquellen für die Krankenhauswahl bei Geburten in der Schweiz
Authors: Wiedenhöfer D. , Keppler S.
Published: November 2015

Seit der Einführung von Swiss DRG im Jahr 2012 haben Frauen in der Schweiz die Möglichkeit der freien Krankenhauswahl. Das Ziel der vorliegenden Arbeit besteht darin, Entscheidungsfaktoren bei der Wahl einer Geburtsabteilung in Schweizer Krankenhäusern zu identifizieren und Informationsquellen hinsichtlich ihres Nutzungsgrades zu bewerten. Hierzu wurden Wöchnerinnen in 7 Schweizer Krankenhäusern der Deutschschweiz schriftlich befragt. Bei der Wahl des Krankenhauses werden Faktoren wie z.B. Fachkompetenz und gute Betreuung durch die Ärzte, gute geburtshilfliche Kompetenz, Fachkompetenz und gute Versorgung durch Pflegekräfte, und eine gepflegte Atmosphäre als wichtig eingestuft. Zu den wichtigsten Informationsquellen zählen Empfehlungen von Freunden, Erfahrungen im Rahmen eines früheren Aufenthaltes, die Fachärztin/der Facharzt, Familie, und die Homepage des Krankenhauses. Informationsabende für schwangere Patienten sind für ein Krankenhaus wichtig, da diese die Entscheidung positiv verstärken. Dem Internetauftritt des Krankenhauses und der Zuweiserbindung kommt zwar eine hohe Bedeutung zu, jedoch spielen Erfahrungen unmittelbarer Bezugspersonen, wie z.B. Freunde und Familie, und eigene Erfahrungen mit dem Krankenhaus eine grössere Rolle.