bluuebunny/crossref_metadata_2025 huggingface dataset:
Intranasal Coronavirus SARS-CoV-2 Immunization with Lipid Adjuvants Provides Systemic and Mucosal Immune Response against SARS-CoV-2 S1 Spike and Nucleocapsid Protein
Authors: Sengupta Anirban , Azharuddin Mohammad , Cardona Maria E. , Devito Claudia , von Castelmur Eleanore , Wehlin Anna , Pietras Zuzanna , Sunnerhagen Maria , Selegård Robert , Aili Daniel , Alamer Ali , Hinkula Jorma , Al-Otaibi Noha
Published: March 2022

In this preclinical two-dose mucosal immunization study, using a combination of S1 spike and nucleocapsid proteins with cationic (N3)/or anionic (L3) lipids were investigated using an intranasal delivery route. The study showed that nasal administration of low amounts of antigens/adjuvants induced a primary and secondary immune response in systemic IgG, mIL-5, and IFN-gamma secreting T lymphocytes, as well as humoral IgA in nasal and intestinal mucosal compartments. It is believed that recipients will benefit from receiving a combination of viral antigens in promoting a border immune response against present and evolving contagious viruses. Lipid adjuvants demonstrated an enhanced response in the vaccine effect. This was seen in the significant immunogenicity effect when using the cationic lipid N3. Unlike L3, which showed a recognizable effect when administrated at a slightly higher concentration. Moreover, the findings of the study proved the efficiency of an intranasally mucosal immunization strategy, which can be less painful and more effective in enhancing the respiratory tract immunity against respiratory infectious diseases.
Economic Growth in the UK: The Inception
Authors: Wardley-Kershaw Julia , Schenk-Hoppé Klaus R.
Published: March 2022

In contrast to the way economic history is often presented, our aim is to provide a concise coverage of economic growth in the UK in four short essays that are written for a general audience of non-economists. In this first essay, we explore the drastic change Britain underwent in the mid-18th century, as agriculture and traditional production methods began to mechanise, increasing productivity to exceed the limits of the land and human strength. For the first time, people witnessed increases in the standard of living within a generation as national wealth soared. It ended centuries of subsistence living in which growth was negligible. As the 19th century dawned, Britain welcomed the steam era, an ignition of modernity, transforming travel, trade and production. We shed light on the wider repercussions of Britain’s economic dominance, highlighting the consequences of rapid urbanisation and assessing the implications of the era of Imperial strength.
Archaeological geomorphometry and geomorphography. Case study on Cucuteni-an sites from Ruginoasta and Scânteia, Iași County, Romania
Authors: Micle Dorel , Măruia Liviu , Török-Oance Marcel , Lazarovici Gheorghe , Lazarovici Mantu Cornelia-Magda , Cîntar Adrian
Published: March 2022

The identification of intrinsic bonds between the men and the geographic space where they lived is one of the desiderata that any archaeologist tries to reach through systemic analysis of an archaeological site reported to the environment. Modern Archaeology uses work methods and techniques borrowed from Geography, which, both for Prehistory and for Antiquity or for the Middle Ages, can offer relevant scientific data regarding the choosing of the place for a house, the placing of a settlement, the preference for certain territories, etc. It is irrefutable the fact that the men constitutes as part of the nature and that they lived in a communion with the environment, dependent of the staple resources, of the geostrategic advantages, of the climatic environment, etc. From the wide pallet of interdisciplinary studies of landscape archaeology, we stopped upon the work methods borrowed from geomorphology (geomorphometry and geomorphography), starting from data gathered while performing the topographical measurements of the Cucuteni archaeological sites from Scânteia and Ruginoasa, Iasi County, Romania. The method, borrowed from Geography, proved to be an excellent historic and archaeological analysis instrument, with surprising results, and this study wants to be a stimulus to use this method at the beginning of any systematic archaeological research, for all types of sites and era. The work methods of the archaeologists’ team from the West University of Timisoara are based on topographical measurements taken with a total station, on orthophotogramms and satellite images analysis, on landscape analysis and geo-physical prospections (magnetometry). The GIS processing of site obtained data corroborated with data obtained from systematic archaeological research of the two sites that we analyze, and also the research of other similar archaeological complexes (including in situ research) belonging to the same cultures and era, from the Moldova region (N-W Romania) took us to the identification of a few geomorphologic factors which constituted as rules of choosing the location for a Cucuteni settlement. The careful analysis of the geomorphometric and geomorphographic altimetry indexes, slope analysis, Sun exposure, water distance, etc. allowed the emit and prove some hypotheses regarding the habitat, settlement size, access roads, defensive system, etc. The present study constitutes into a helping instrument for archaeologists which want to use a scientific method to validate empiric observations taken in situ, and also their processing technique used to obtain sketches, plans and revealing topographic maps for any systematic research of an archaeological site.
The Oldest Snail (Lithoglyphus naticoides) necklace discovered in Romania in the Gravettian III stratum of Poiana Cireșului-Piatra Neamț [25.760±160 –27.321±234 B.P.(31.969 ka)]
Authors: Cârciumaru Marin , Ţuţuianu-Cârciumaru Minodora
Published: March 2022

The settlement of Poiana Cireșului-Piatra Neamț may be indisputably considered, especially through the hard animal material industry found here and mostly through its ornaments and art objects, the most significant in Romania and probably in this part of Europe. The settlement is located 4 km far from Piatra Neamț, on the right bank of the Bistriţa river, close to the confluence with the Doamna brook. In the Gravettian III level, dated, as we have already mentioned, between 25.760 ± 160 B. P. and 27.321 ± 234 B. P. (C. Zeeden et al., 2009), the archaeological campaign of 2004 revealed only 12 pierced snail shells, found at an average depth of approximately 375 cm. they were assigned to the Lithoglyphus naticoides species. As the freshwater snail necklace of Poiana Cireșului is the oldest testimony of this kind in Romania, we can presume the transmission, for future cultural stages, of a powerful tradition in this respect. Furthermore, we cannot ignore that it is unique, from a certain point of view, in the European Gravettian. Experimental reconstitution was essential in understanding the reason of choosing certain materials to make mobiliary art objects. This type of research resulted in revealing data on the relations between gesture, material and tool, the transformation of the blank into a symbol depending on its behaviour during the engraving or piercing operation. The snail shell necklace from the Gravettian of Poiana Cireşului is an illustrative example. The Gravettian man, acting according to a tradition which was deep-rooted in his conscience, exploited what the environment was offering him, the necessary symbolic message being obtained through adaptive means.
The micromorphology of the Gravettian occupation sequence from Poiana Cireşului (Piatra Neamţ, Romania)
Authors: Haită Constantin
Published: March 2022

In this paper, we present the first results of the micromorphological study of the anthropic sequence from the Upper Paleolithic site of Poiana Cireşului (Neamţ County). The stratigraphic succession of the layers attributed to the Gravettian occupation was studied on the Western, Northern and Eastern profiles, in Section V. After the resin impregnation and the subsequent induration, the samples were processed in order to obtain the thin sections for the optic microscopy study. Thin sections were analysed using a polarising petrographic microscope (Olympus BX 60). The stratigraphic units were systematically described and interpreted, and the identification of the sedimentary facies was achieved at magnifications between x100 and x600, using standard methods. The study was centred on the characterization of the sedimentary matrix, and of the anthropogenic features, in order to identify the units corresponding to anthropic and natural forming processes, and to characterize from this point of view the studied occupational sequence from Poiana Cireşului.
Delimited Funerary Spaces – Hellenistic Tumuli with Stone Enclosures at Kallatis
Authors: Sîrbu Valeriu , Ștefan Maria-Magdalena
Published: March 2022

This article analyzes the practice of delimiting tumuli graves with stone enclosures, mainly in the Classical and Hellenistic cemeteries of Kallatis/ Callatis (Mangalia), a Dorian establishment on the western Black Sea, following the recent exploration of a monumental tumulus ensemble, the Documaci Mound, built at the end of the 4th c. BC-early 3rd c. BC at 3 km west of the ancient city limits. The mound, covering a chamber tomb with semi-cylindrical vault, plastered walls and dromos, was surrounded at its base, measuring around 169 m in circumference, by a stone wall, 1.2 m high and 87 cm thick. After offering a systematic description of the Documaci Mound enclosure wall, the authors take on the occasion to discuss certain funerary architectural developments in the Greek colonies on the western and northern Black Sea shores, related to the use of periboloi and other stone delimitations (stone rings, kerbs, krepidae) during the Classical period, establishing also general connections with the building trends of the early Hellenistic period of erecting imposing funerary monuments in contexts related to enhancement of the individual identity expression in Macedonia and Thrace.
Impact of Medication Reconciliation by a Dialysis Pharmacist
Authors: Dyer Summer A. , Nguyen Victoria , Rafie Sally , Awdishu Linda
Published: March 2022

Key Points

Integrating a pharmacist into a hemodialysis unit significantly reduced medication discrepancies and medication-related problems over time.

Medication reconciliation for the Centers for Medicare and Medicaid Services End-Stage Renal Disease Quality Incentive Program can be optimally performed by a dialysis pharmacist.
Taxonomic Revision of Barbacenia (Velloziaceae) Atlantic Forest Inselberg Group, with Two New Species
Authors: Mello-Silva† Renato , Cabral Andressa
Published: March 2022

The systematics of the Barbacenia Vand. Atlantic Forest Inselberg group (Barbacenia AFI), and the description of two new AFI species, B. amphirupia Mello-Silva & Andr. Cabral and B. maritima Mello-Silva & Andr. Cabral, are here presented. Lectotypes are designated for B. fannieae (N. L. Menezes) Mello-Silva, B. mantiqueirae Goethart & Henrard, B. purpurea Hook. var. minor Seub., B. squamata Herb., and Vellozia coerulescens Hort. Belg. ex Gumbl., and a neotype is designated for B. foliosa Goethart & Henrard. Barbacenia burlemarxii L. B. Sm. & Ayensu was placed into synonymy of B. pabstiana L. B. Sm. & Ayensu, B. caricina Goethart & Henrard of B. brevifolia Taub., B. gaveensis Goethart & Henrard, B. foliosa, B. purpurea var. minor, and B. seubertiana Goethart & Henrard under B. squamata, B. ionantha L. B. Sm. and B. monticola L. B. Sm. & Ayensu under B. irwiniana L. B. Sm., and V. coerulescens under B. purpurea. An identification key and morphological and anatomical descriptions for the species are presented, as well as comments on the affinities among the species, geographical distribution, and conservation status.
Counseling as a means of providing safe social support during the COVID-19 pandemic
Authors: Trębski Krzysztof , Młyński Józef
Published: March 2022

The COVID 19 outbreak has affected people’s physical and mental health and triggered an avalanche of consequences that many are unable to cope with, and because of the pandemic, even relatives and friends are unable to help in this situation. Many people experience all kinds of difficult situations (such as relationship problems, health, social, educational or economic difficulties) that are not pathological problems but for which individuals are unable to find a suitable solution. Counseling as a helping relationship is a good way for them to gain self-awareness and find the resources they need to make the necessary changes in their lives. The counselors, as professionals in a helping relationship, can help them get through difficult times by providing the necessary support to begin their journey to well-being. The article presents counseling as an opportunity to provide safe social support to people during the COVID 19 epidemic, but also highlights the difficulties this type of service can bring.
The psychologist’s diagnostic competences in issuing psychological and judicial opinions in divorce cases involving children
Authors: Pisarska Agnieszka
Published: March 2022

Divorce cases where divorcing spouses have minor children pose a particular challenge for psychologists and lawyers. The court decides on important matters regarding the child and the family, but formally does not have sufficient knowledge of the psychological functioning of family members, and the decision is based on a psychological and judicial opinion. The psychologist does not make legally binding decisions regarding the family, but acts as an expert with so-called special information in selected areas of psychology, which allows preparing a psychological and judicial opinion on the functioning of the family to support the court’s decision-making process. Particular diagnostic competence of a psychologist: knowledge, skills and ethical attitude increase the likelihood of accurate and reliable psychological diagnosis and contribute to making the psychological and judicial opinion more useful to the court. The article presents selected legal and psychological issues related to the role of a psychologist and the process of diagnosing in providing psychological and judicial opinion on divorce matters where the partners are parents of minor children. It presents the psychologist’s diagnostic competences: (a) knowledge, including the knowledge of research areas  important in making psychological diagnoses and specific issues (including the concept of resilience, parentification, parental alienation, the child’s adaptation, conflict between partners, the child’s best interest clause as a principle of family law, evidence-based diagnosis), basic legal principles on divorce, the status of an expert psychologist and psychological and judicial opinion, as well as other provisions which are not source of law in the form of guidelines and standards; (b) skills relating to effective planning and execution of multi-person diagnosis, the construction of the psychological and judicial opinion, the selection of diagnostic tools, the presentation of hypotheses, transparent and comprehensive data analysis and the formulation of conclusions; (c) an ethical attitude taking into account the special status of the psychologist and diagnostic relationship in divorce matters, taking into account ethical dilemmas and separateness of diagnosis conducted out of court.
Ways of shaping love for God and people and historical memory during the Year of St. Stanislaus Kostka
Authors: Kućko Wojciech
Published: March 2022

The aim of the article is to show the many various ways in which the Year of St. Stanislaus Kostka, announced in 2018 on the occasion of the 450th anniversary of his death, was celebrated, and how were the ways of shaping love for God and people during that time. The article presents a review of the most important facts about the main jubilee celebrations in Poland and abroad which were also possibilities to build the historical memory. The year of St. Stanislaus Kostka was part of a long tradition of celebrations marking the anniversaries of this patron saint of Poland, held since the year of his beatification (1602/1605), and more solemnly since his canonization in 1726. The text discusses the worldwide and nationwide events commemorating the Saint of Rostkowo, and presents the main publications and conferences devoted to this saint. It also mentions the exhibitions and various pastoral initiatives taken during the year. Particular attention has been paid to celebrations in the Diocese of Płock, where Rostkowo, the birthplace of St. Stanislaus Kostka, is located. On this basis, the pertinence of the saint’s message has been discussed as well.
Outcome Predictors of Tocilizumab Administration in Patients with Severe COVID-19
Authors: Теренин М.А. , Ялонецкий И.З. , Романова Е.В.
Published: March 2022

В ретроспективном исследовании авторы попытались найти предикторы исхода у 100 пациентов с тяжелой формой COVID-19, получивших тоцилизумаб и проходивших лечение в отделении интенсивной терапии и реанимации. Все пациенты были разделены на 2 группы в зависимости от исхода заболевания (I группа – выжившие, II группа – умершие). Среди пациентов в возрасте до 60,5 года и с индексом коморбидности Чарлсона ≤2,5 балла прогнозировалась низкая вероятность летального исхода после введения тоцилизумаба. Пациенты, у которых до инфузии тоцилизумаба определялись ИЛ-6≤101 пг/мл, альбумин в крови ≥30,5 г/л и PaO2/FiO2≥125,5 мм рт. ст., относились к группе низкого риска летального исхода. Быстрое восстановление уровня лимфоцитов в крови со 2-х суток после инфузии тоцилизумаба может рассматриваться как предиктор благоприятного прогноза.

In a retrospective study, the authors attempted to find outcome predictors in 100 patients with severe COVID-19 who received Tocilizumab and were treated in the ICU. All patients were divided into 2 groups depending on the outcome of the disease (group I – survivors, group II – deceased). Among patients under the age of 60.5 years and with a Charlson comorbidity index ≤2.5 points, a low probability of death was predicted after the administration of Tocilizumab. Patients who had IL-6 ≤101 pg/ml, blood albumin ≥30.5 g/L, and PaO2/FiO2 ≥ 25.5 mm Hg before the Tocilizumab infusion were at low risk of mortality. The rapid recovery of blood lymphocyte levels from the 2nd day after tocilizumab infusion can be considered as a predictor of the favorable prognosis.
New Approaches to Treatment of Patients with Autoimmune Ophthalmopathy (the Review of the 2016 and 2021 Clinical Practice Guidelines of the European Group of Graves’ Orbitopathy (EUGOGO) for the Management of Graves’ Orbitopathy Endorsed by the European Society of Endocrinology (ESE))
Authors: Данилова Л.И. , Короленко Г.Г.
Published: March 2022

Лечение аутоиммунной офтальмопатии (АИО) остается непростой задачей для клиницистов, требует пациентоориентированного подхода и анализа эффективности каждого этапа терапии. В обновленных рекомендациях четко прописан алгоритм лечения АИО с выделением терапии первого и второго уровня. Глюкокортикоиды остаются первой линией терапии. Значительный прорыв в понимании патогенеза АИО позволил активно использовать как уже известные, так и новые препараты антипролиферативного действия, биологическую терапию как вторую линию лечения при неудаче применения глюкокортикоидов. Возросло значение лучевой терапии на область орбит. Выделены приоритеты при лечении АИО и тиреотоксикоза в случае болезни Грейвса. Ознакомление эндокринологов и офтальмологов с представленными рекомендациями позволит улучшить результаты лечения пациентов с АИО и качество их жизни. С учетом новых трактовок механизмов развития АИО и практического опыта представляется целесообразным изменение протокола лечения АИО в Республике Беларусь.

The medical management of autoimmune ophthalmopathy (AIO) is a challenge for clinicians requiring a thoughtful analysis of each stage of treatment and considerable skill. Based on the accumulated experience, the AIO mamagement algorithm which provides thefirst- and the second-linetreatmentis clearly defined in the updated Guidelines. Due to their pathogenic validity, effectiveness and widespread availability, glucocorticoids have remained the first-line treatment. A major breakthrough in the understanding of AIO pathogenesis has allowed to actively usewell-establishedand new antiproliferative drugs andbiological agents as a second-line treatment if there is no response to glucocorticoids. The efficacy of orbital radiotherapy has increased. Priorities in the AIO management and treatment of thyrotoxicosis in Graves’ disease are highlighted. Endocrinologists’ and ophthalmologists’awareness of the updated Guidelines will significantly improve the treatment outcomes in patients with AIO and their quality of life. Taking into account the new insights into the pathogenesis of AIO and clinical experience, it seems appropriate to amend the protocol for the medicalmanagement of AIO in the Republic of Belarus.
Involvement of older people in the processes of modern digital transformations
Authors: Барышева Г.А. , Клемашева Е.И. , Недоспасова О.П. , Нгок ТхиБик Чан , Тханг Чиен Нгуен
Published: March 2022

Проанализированы результаты социологического исследования «Цифровые технологии для томичей пожилого возраста», выполненного в Томске (май 2021 г.) с применением методологии фокус-групповой дискуссии. Исследование показало, что у многих граждан пожилого возраста нет психологической готовности и устойчивой мотивации к тому, чтобы интегрироваться в цифровую реальность. Выявлены причинно-следственные связи между многогранной вовлеченностью граждан старшего возраста в социум и их навыками владения и применения цифровых технологий, которые делают людей более сильными, а общество в целом - более инклюзивным перед лицом цифрового будущего. Предложены рекомендации по вовлечению пожилых людей, заинтересованных продвигать идеи цифрового качества жизни и возможность использовать новые сервисы, в процесс цифровой трансформации в качестве активных акторов для формирования нового, привлекательного и безопасного цифрового будущего.

The analysis of the results of the sociological study «Digital Technologies for Tomichs» of the elderly, carried out in Tomsk (May, 2021) using the focus-group discussion methodology, was carried out. The study showed that many elderly citizens have no psychological readiness and sustained motivation to integrate into digital reality. Causal relationships have been identified between the multifaceted involvement of older citizens in society and their skills in mastering and using digital technologies, which make people stronger and society as a whole more inclusive in the face of the digital future. Recommendations on the involvement of older people who have an interest in promoting ideas of digital quality of life and the opportunity to use new services in the process of digital transformation as active actors for the formation of a new, attractive and safe digital future are offered.
Maintenance of persons older the active working age high-tech medical care on the example of the astrakhan region with 2015 for 2019
Authors: Набережная И.Б.
Published: March 2022

В статье представлена динамика численности населения старше трудоспособного возраста Астраханской обл. и уровень их обеспеченности высокотехнологичной медицинской помощью. Подробно представлены и проанализированы суммарные показатели за пятилетний период (2015-2019 гг.) по всем медицинским организациям, оказавшим данный вид помощи рассматриваемой категории лиц. Выявлено увеличение числа оказанных высокотехнологичных видов помощи в 1,6 раза, а обеспеченности - в 1,5 раза, несмотря на то что количество лиц пенсионного возраста растет из года в год. Наиболее востребованными профилями являются сердечно-сосудистая хирургия, травматология и ортопедия, онкология и офтальмология, в сумме составляющие 95 %. Абсолютное большинство исходов приходится на улучшение (92,4 %). Летальный исход составил 0,9 %, причем в значительной части случаев он пришелся на сердечно-сосудистую хирургию (80,8 %). Наиболее востребованным месяцем для оказания высокотехнологичной медицинской помощи явился июнь с максимальным индексом сезонности (123,2 %). Минимальный индекс сезонности был отмечен в январе (47,9 %). Средняя длительность пребывания в стационаре у данной группы лиц составила 10,4±0,1 дня. Недостаточно доступен данный вид помощи для жителей отдаленных районов, но все же их количество постепенно возрастает.

In article dynamics of variation of a population older an active working age of the Astrakhan area and a level of their security is presented by high-tech medical care. Total parameters for the five years’ period on all medical organizations which have rendered the given type of the help of the considered category of persons are in detail presented and analysed. The increase of quantity of the rendered high-tech types of the help in 1,6 times, and security in 1,5 times in spite of the fact that the quantity of persons of a pension age grows from year to year is revealed. The most demanded structures is the cardiovascular surgery, traumatology and orthopedy, oncology and ophthalmology, in the sum components of 95 %. The overwhelming majority of outcomes is necessary on improvement (92,4 %). The lethal outcome has made 0,9 %, and in a major part of cases it has fallen to cardiovascular surgery (80,8 %). Most demanded month for rendering high-tech medical care June, with the maximal index of seasonal prevalence (123,2 %) was. The minimal index of seasonal prevalence has noted been in January (47,9 %). Average duration of stay at the given group of persons has made 10,4±0,1 day. The given type of the help for residents of the remote areas is insufficiently available, but nevertheless their quantity one step at a time increases.
Intraoperative and early postoperative risk factors of development of acute cerebrovascular accident after coronary artery bypass grafting in the elderly age
Authors: Шнитман Т.А. , Труханова И.Г. , Булгакова С.В. , Захарова Н.О.
Published: March 2022

В статье представлены данные, посвященные проблеме ИБС, хирургической реваскуляризации миокарда, а также риску развития ОНМК у пожилых пациентов с аортокоронарным шунтированием (АКШ). Авторами проведено исследование по выявлению факторов риска развития ОНМК у пожилых пациентов. Выявлены предикторы развития ОНМК в операционном и раннем послеоперационном периодах. Доказано, что время экстубации, увеличение уровня PCO , гиперлактатемия являются надежными интраоперационными и ранними послеоперационными предикторами ОНМК у пожилых пациентов с АКШ. Практическая значимость исследования заключается в применении его результатов для прогнозирования развития периоперационного инсульта у пожилых пациентов с АКШ.

The article presents data on the problem of ischemic heart disease, surgical myocardial revascularization, as well as the risk of developing acute cerebrovascular accident (ACVA) in elderly patients with coronary artery bypass grafting (CABG). The authors conducted a study to identify risk factors for the development of stroke in elderly patients. Predictors of ACVA development in the operational and early postoperative periods were identified. It has been proven that the time of extubation, an increase in PCO levels, and hyperlactatemia are reliable intraoperative and early postoperative predictors of stroke in elderly patients with CABG. The practical significance of the study lies in the application of its results to predict the development of perioperative stroke in elderly patients with CABG.
Mundos y agencias posthumanos
Authors: Lo Feudo Yanina Maribel
Published: March 2022

Si la historia de la metafísica es, como sugiere Heidegger, esencialmente humanista, los cuestionamientos que se han dirigido al humanismo, aunados bajo el rótulo de posthumanismo, tienen frente a sí el desafío de establecer una ruptura con una hegemonía bimilenaria de lo humano frente a lo no-humano. En este trabajo interesará problematizar el modo en que el modelo humanista ha atribuido al hombre el privilegio de ser el único ser capaz de actuar y de formar mundo. El objetivo será explorar una perspectiva expandida de la agencia hacia el mundo animal, vegetal y material. A partir de la proliferación de las posibilidades de la agencia se descubren, a su vez, distintas maneras de formar y habitar mundos: el mundo como esfera totalizante, como conjunto de mundos circundantes y como mixtura de agencias materiales. Finalmente, se contrastará esta perspectiva tendiente hacia la des-jerarquización de la agencia humana con las dificultades que plantea la noción de Antropoceno. La responsabilidad del hombre frente al alcance geológico de su actividad vuelve a poner el acento en la centralidad de su capacidad agencia, mostrando así las contradicciones que se gestan en los intentos de ir más allá del humanismo.
Un reto para el debate jurídico: la regulación de la innovación abierta
Authors: Pinazo Dallenbach Julián
Published: March 2022

En la actualidad, para innovar resulta cada vez más necesaria la interrelación entre distintos actores (start-ups, corporaciones, universidades, centros de investigación, usuarios...). La proporción de conocimientos externos utilizados es tal que nos encontramos ante lo que Chesbrough denomina innovación abierta. Ello supone un reto para el debate jurídico por la conjunción de varias temáticas: propiedad intelectual, relación entre actores y, finalmente, el desarrollo de los países y el bienestar social. Es por ello que es preciso reflexionar acerca de cómo el derecho debe regular la innovación abierta.
Features of perception of the phenomenon of the Armenian Genocide in the public opinion of Yerevan residents in the context of the 100th anniversary of the tragedy (analysis of the results of sociological surveys)
Authors: Hovhannisyan H. O. , Hovhannisyan H. H. , Oganyan K. M.
Published: March 2022

The research study was conducted in two stages, in 2015 and 2016 from March 15 to April 15 utilizing the method of formalized interview. Each phase of the survey involved 560 Yerevan residents. As the results of the research come to prove, the mosaic of the public perception and the psychological reflection of the phenomenon of the Armenian Genocide is very sophisticated. The moods of regret, pain, depression, declining moods, complaint, wrath, revenge, hope and optimistic views for future are intertwined and bound together. These moods and feelings appear next to each other and quickly alternating. As a result of sociological surveys, a number of trends and transformations in public opinion and perception were revealed. The authors explain these changes by three groups of domestic political and foreign policy factors.
World experience in defining and measuring poverty
Authors: Nematova D. T.
Published: March 2022

This article analyzes the world experience in defining poverty and measuring poverty. In particular, the experience of the World Bank in defining poverty and defining poverty, the Gini coefficient and the Tile index, the analysis of the activities of the international community Oxfam and the UN to reduce poverty are highlighted. The grouping of various causes of poverty in the modern world is shown. An analysis of the history of the International Oxfam Society is given.
Directions and prospects of researching the sociology of youth in the conditions of transformation of Russian society
Authors: Terekhin A. S.
Published: March 2022

The article examines the main stages, conceptual directions and prospects for the development of the sociology of youth in Russia. Based on the analysis of a number of relevant studies, it was concluded that the study of the Internet and social networks as the most promising object of consideration in the framework of the sociology of youth.
Public discussions and public hearings as a form of direct expression of will in the Russian Federation
Authors: Sharyapova E. A. , Obukhovich V. E. , Taube I. S.
Published: March 2022

The article raises questions of the formation of civil society around urban planning. The concepts of “public discussions” and “public hearings” enshrined in urban planning legislation are of interest to theorists and urban planners, not only because this is an obligatory stage in the adoption of urban planning documents, but also because more and more often citizens are turning to their right to direct expression of will in the form of public discussions and public hearings. The authors tried to analyze and suggest possible ways to increase the civic engagement of the local population of the municipality.
STUDY OF FACTORS INFLUENCING MAJOR AMPUTATION IN DIABETIC FOOT
Authors: Naik Deepak , P B Thrishuli , Kumar S Praveen
Published: March 2022

Introduction Diabetes becoming progressively dominant global due to decreased physical activity, westernizing food behaviours, obesity; consequently, rising the diabetic foot incidence. Patients with diabetes predicted to have 25% possibility of getting at least a single episode of diabetic foot ulcer through their lifespan further ulcer progress and ends in Amputation .The main aim of study is to determine various factors that are inuencing Major amputation in diabetic foot Methodology Prospective observational study of diabetic patients undergoing amputation in JSS hospital Mysore over period of 18 months with sample size of 45 was done. Data was collected from patients by History taking, clinical examination and relevant investigations. Factors like age, duration of diabetes, previous history of amputation, smoking were collected from patient. Arterial insufciency, neuropathy were assessed by Peripheral pulse, ABPI and monolament test respectively. Investigations like HBA1c, Haemoglobin, serum albumin ,Renal function test ,Xray were obtained. After collection of data statistical analysis was made by mean, median, SD, proportion and Inter-quartile range q1 -q3 and determine various factors inuencing amputation in diabetic foot Result Total of 45 patients undergoing amputation were studied of which Gender, Smoking, Previous history of minor amputation, Elevated HBa1c, Presence of neuropathy, Vasculopathy, Hypo albuminemia were statistically signicant Conclusion In this study history of smoking, history of minor amputation, Elevated HBa1c, Presence of neuropathy, Vasculopathy, Hypo albuminemia are signicant factors inuencing/ Predicting amputation in Diabetic patients
LIVED EXPERIENCES OF PARENTS OF CHILDREN SUFFERING FROM EPILEPSY: A PHENOMENOLOGICAL STUDY
Authors: Thakur Jyoti , Sharma Sunita , Kaur Sukhwinder , Choudhary Anupama , Saini Lokesh
Published: March 2022

Epilepsy is one of the common neurological conditions characterized by recurrent episodes of epileptic ts. Parents of children suffering from
Epilepsy face many social and psychological problems. The aim of the study was to explore the lived experiences of parents of children suffering
from Epilepsy. Purposive sampling technique was used and twenty four parents of children suffering from Epilepsy were interviewed. Data was
collected by taking in-depth interviews of parents of children suffering from Epilepsy. Recording of interviews was done by audio recorder.
Verbatim were prepared, from which sixteen themes and forty seven subthemes were identied and described.The result highlighted that parents of
children suffering from Epilepsy had various types of experiences they use various measures to treat Epilepsy including ayurvedic medicines,
homeopathic treatment and also go to various witch quacks and temples. Parents of children suffering from Epilepsy passes through the stages from
where they have to face many types of problems like psychological problems, social problems, family problems, nancial problems and
occupational problems. There is a need to create awareness about Epilepsy on a nation-wide basis to dispel the misconceptions and stigma through
effective and robust programs with the aim to lessen the disease burden.
EFFECT OF MCKENZIE TECHNIQUE WITH ICT AND CONVENTIONAL EXERCISE WITH ICT IN CERVICAL RADICULOPATHY
Authors: P Darji Hardi , M Soni Krupa
Published: March 2022

Cervical radiculopathy is marked by nerve compression of a herniated disk. McKenzie and ICT are more used in participants with Cervical
Radiculopathy. There are no studies that combine the McKenzie with ICT and Conventional Exercise with ICT in participants with Cervical
Radiculopathy. The study aimed to nd the effects of the McKenzie Technique with ICT and Conventional Exercise program with ICT in
participants with Cervical Radiculopathy to determine the better of these for benet of participants. So, a Quasi-Experimental study was conducted
with 30 participants that featured Cervical Radiculopathy. They were studied for a 4-weeks intervention. They were divided into 2 groups by
convenience sampling: - Group A: McKenzie Technique with ICT and Group B: Conventional Exercise with ICT. Pre- and post-treatment data
were collected and analyzed using SPSS 22.0. Paired and unpaired t-test was used to nd out the signicance of the treatment. A signicant
improvement in pain, disability, muscle strength, and endurance (p<0.05) after the treatment was found in both groups. Greater statistically
signicant improvement was seen in Group A as compared to Group B. Thus, the study concluded that McKenzie Technique with ICT was more
effective in Cervical Radiculopathy
EFFECTIVENESS OF ACUPRESSURE PEN WITH ALEXANDER TECHNIQUE IN PARTICIPANTS WITH LOW BACK PAIN AMONG BUS DRIVERS- A RANDOMIZED CONTROLLED TRIAL
Authors: Patel Jinal , Patel Shivani
Published: March 2022

Background: Low back pain has a signicant impact on functional capacity, as pain restricts occupational activities and is a major cause of
malingering. Acupressure is originated from China basically and it is in use from ages in every disease and disorders to treat participants with
manual acupressure and after a time electro acupressure came into introduction. Frederick Matthias Alexander, founder of the Alexander technique
and it uses enhanced kinaesthetic awareness and voluntary inhibition to prevent non-benecial movement pattern.
Aim:To nd out the effect of acupressure pen with alexander technique in low back pain among bus drivers.
Objectives:To decrease pain sensitivity
To improve exercise tolerance and endurance
To compare the experimental group to the control group
Method: Thirty participants were selected based on inclusion and exclusion criteria. They were treated with acupressure pen for three days/week
and AT for ve days/week
Results:The data was analyzed using SPSS Version22. Parametric test was used. In group A improvement was seen.
Conclusions: Acupressure pen along with Alexander technique are effective to reduce low back pain and improve daily life activities among bus
drivers.
EXPERIMENTAL & ANALYTICAL STUDY ON EFFECT OF EMOTIONAL LITERACY PROGRAMME THROUGH EMOTIONAL AWARENESS ON SOCIAL SKILL DEVELOPMENT OF PRIMARY GRADE CHILDREN (3RD & 4TH STANDARD) STUDENTS
Authors: Sohanlal Shrivastav Deepakkumar , Sandeep Jaywant Shailaja
Published: March 2022

Education in school have strong impact on social, emotional development along with the development of academic skills. Relationships &
emotional process has strong impact on how & what we learn. Emotional awareness is the ability to recognise and make sense of not just your own
emotions, but also those of others. It is also known as emotional Intelligence. Our school curriculum lacks the skill development for the emotional
awareness the study was undertaken to develop emotional awareness at earlier age of schooling, through emotional literacy program. It was
rd th intended to evaluate the effect of emotional literacy training on emotional awareness in primary grade children (3 & 4 grade).
There were total 233 (55.90%) male participants out of total 417 participants of were total 184 (44.10%) females' participants. They were given
fortnightly, an hourly session (eight weeks i.e. 4 sessions), of emotional literacy program through various activities & games. The students were
improved in ability to differentiate emotions, Hindi medium students were better in ability of children to verbally share the emotions among them(p
=0.000). The open expression of emotions, so the bodily awareness of different emptions showed signicant improvement. Emotional intelligence
is a tool used by man to master or conduct his own behaviours, to adjust him in the environment around. The group dynamics developed through
games, many students reported inclusive feelings. The inclusion of emotional literacy program in regular curriculum may benet children in
developing social competencies & further enhancing the better skills for integrated social development.
Causes of Complete Removable Denture Renewal: A Tunisian Cross-Sectional Study
Authors: Tayachi Y. , Tayari O. , Bedhief Rabeb , Jaouadi J.
Published: March 2022

The renewal of removable dentures is often suggested to denture wearers subject to discomfort. However, the impact of this rehabilitation on patients’ oral health related quality of life and their removable dentures related satisfaction is still unknown. This study was aimed at assessing these patient-centered outcomes and the potential impact of different factors. Materials and methods: • In our study, the most appropriate parameters to assess the prosthetic quality have been collected to evaluate the satisfaction perceived by patients about their denture; their complaints and the causes of the refabrication. • A completely new questionnaire has been drawn up including: Reason patients requested new dentures (fit, esthetics, broken denture, wear, recommandations of dentist, extractions), satisfaction with the old prosthesis (general, retention, stability, comfort, pronunciation, chewing, esthetics), and technical quality of the old prosthesis as assessed by a dentist (stability, retention, fit, border, wear, esthetics). • Gender, age and socio-economic status were included as confounding variables • Fifty patients have been included in the survey, they have undergone a clinical examination, and we have filled out the questionnaire anonymously. The Chi2 test, ANOVA test, and Pearson correlation test have been employed to relate clinical and anamnestic factors to the causes of removable denture renewal.
Exploring Interventions for increasing Students’ Participation in Science and Technology Bachelor Degree Programmes in Public Universities, Kenya
Authors: Wanyama Bernard Wasilwa
Published: March 2022

This paper argues that although the government and public Universities have committed to initiating several intervention measures targeting increasing students’ participation in Science and Technology Programmes, only 29% of students were studying a course in these areas by the year 2016. Such scenario implies that the country is seriously lagging behind in the realization of Kenya Education Sector Support Programme (KESSP I) participation target of 50%. The purpose of this study was to evaluate some interventions that could be employed to increase student participation. The study employed descriptive survey design to target 31 public Universities, 237 lecturers, 107 Heads of Departments (HoDs) and 31 Academic Registrars. Purposive sampling technique was employed to select three Public Universities, 12 HoDs, 24 lecturers, and three Academic Registrars who participated in the study and interview schedules were utilized to collect data. Qualitative data was analyzed thematically and reported in form of tables, quotations and narrations while quantitative data was analyzed by use of frequencies, percentages, means and pie charts. It was established that Inter-governmental co-operations, linkages and agreements, University-secondary schools linkages, Income Generating Activities (IGAs) and relying on philanthropic gestures were interventions employed. The study concludes that most intervention measures had not played a significant role in enhancing students’ participation and recommends that Universities should engage in Public- Private- Partnerships (PPP) in funding University education, including but not limited to the establishment of robust endowment funds through alumni and other donors for scholarships, establish and commercialize Intellectual Property Organization (IPO), promote co-operation for research, offer incentives to staff winning research grants, engage in value engineering and also diversify sources of income by adopting suitable business models ......
Aesthetic Values in Kamba Children’s Play Songs
Authors: Mutisya Brigitte Mutindi , Muhoro Dr. Peter
Published: March 2022

The involvement of children in the creation and performance of children’s songs creates the aesthetic beauty and the comprehension of themes. However, oral literature has been stereotyped as a rural concept and few scholars have given it serious literary attention to children’s creative expression. Therefore, this study examines the aesthetic value and performance in Kamba children’s play songs. The study employed Hymes (1991) ethnopoetic theory. The study employed ethnographic research design. Data was collected using participant observation. The findings of the study reveal that the songs are embedded on concrete textual traditions of Kamba society and they carry the aesthetic values of friendship and unity, aesthetic value of responsibility, aesthetic value of environmental issues, aesthetic value of Kinship System, aesthetic value of traditional food and the aesthetic value of hard work and condemn the vice of laziness. The study concludes that there are important aesthetic values in Kamba Children play Songs.
Challenge of the Massification in Teaching of Health Science (Preliminary Approach at Nursing High School of Lubumbashi)
Authors: Mamie MUJINGA KALENGA , Freddy MUNUNG NGWEJ , Dora KAFUTSHI MUKEMO , BELINDA KITAMBO , Mathilde MUSANGU SUNGULIYA , Daniel MAYENA KADITSHI , Emmanuel MUMBA WA MUMBA , Fortunat MWINKEU Narcisse , MUKEM KATUMBO
Published: March 2022

Introduction: The increasing of the number of the students remains a problem in high colleges in the Democratic Republic of Congo. Confronted to a big number of students, diverse challenges are raised up in order to reach the level that we normally have to attend. This approach had fixed the inventory of fixtures on the number of the students is concerned and yet identify the challenge on it. Method: A transversal descriptive approach has been applied. Different data had been collected in the honors lists and in the register-book. From 1992 to 2016, 33.690 students were enrolled. Besides, 18 teachers have participated to our research. Results: In nursing, a sensitive increasing of a peak of 400 students from 2007 has been observed. In 2008, 1167 students in G1, 769 students in G2 and 539 students in G3 have been enrolled as a peak. In midwife section, in spite of the reformation, the number of students in different degrees remains high with a peak of 110 students in G1 in2009; of 137 students in G2 in 2010 and of 130 students in G3 in 2011. In EASI, the graduate cycle has enrolled more students in 2003 (a peak of more than 200 students). In the path of laboratory, nutrition and Management health Institution, the number of students was increasing every year. In the degrees where the approach of competency is applied, the ratio between teacher and students was of 1/13 in nursing and 1/29 in midwife. In training, the ratio was of 1/33. Conclusion: As far as the challenge is concerned, we have noticed the increasing of the number of students, the weak number of head of training and educated teachers in approach of competency, difficulty in applying teaching methods when the group of students to teach is increased and overweight in work.