bluuebunny/crossref_metadata_2025 huggingface dataset:
Spinning gluons from the QCD light-ray OPE
Authors: Chen Hao , Moult Ian , Zhu Hua Xing
Published: August 2022

Abstract

We study the transverse spin structure of the squeezed limit of the three-point energy correlator, $$ \left\langle \mathrm{\mathcal{E}}\left({\overrightarrow{n}}_1\right)\mathrm{\mathcal{E}}\left({\overrightarrow{n}}_2\right)\mathrm{\mathcal{E}}\left({\overrightarrow{n}}_3\right)\right\rangle $$

ℰ

n
→

1

ℰ

n
→

2

ℰ

n
→

3

. To describe its all orders perturbative behavior, we develop the light-ray operator product expansion (OPE) in QCD. At leading twist the iterated OPE of $$ \mathrm{\mathcal{E}}\left({\overrightarrow{n}}_i\right) $$
ℰ

n
→

i

operators closes onto light-ray operators $$ {\mathbbm{O}}^{\left[J\right]}\left(\overrightarrow{n}\right) $$

O

J

n
→

with spin J, and transverse spin j = 0, 2. We compute the $$ \mathrm{\mathcal{E}}\left({\overrightarrow{n}}_1\right)\mathrm{\mathcal{E}}\left({\overrightarrow{n}}_2\right) $$
ℰ

n
→

1

ℰ

n
→

2

, $$ \mathrm{\mathcal{E}}\left({\overrightarrow{n}}_1\right){\mathbbm{O}}^{\left[J\right]}\left({\overrightarrow{n}}_2\right) $$
ℰ

n
→

1

O

J

n
→

2

and $$ {\mathbbm{O}}^{\left[{J}_1\right]}\left({\overrightarrow{n}}_1\right){\mathbbm{O}}^{\left[{J}_2\right]}\left({\overrightarrow{n}}_2\right) $$

O

J
1

n
→

1

O

J
2

n
→

2

OPEs as analytic functions of J, which allows for the description of arbitrary squeezed limits of N -point correlators in QCD. We use these results with J = 3 to reproduce the perturbative expansion in the squeezed limit of the three-point correlator, as well as to resum the leading twist singular structure for both quark and gluon jets, including transverse spin contributions, as required for phenomenological applications. Finally, we briefly comment on the transverse spin structure at higher twists, and show that to all orders in the twist expansion the highest transverse spin contributions are universal between quark and gluon jets, and are descendants of the leading twist transverse spin-2 operator, allowing their resummation into a simple two-dimensional Euclidean conformal block. Due to the general applicability of our results to arbitrary correlation functions of energy flow operators, we anticipate that they can be widely applied to improving our understanding of jet substructure at the LHC.
The tadpole conjecture in asymptotic limits
Authors: Graña Mariana , Grimm Thomas W. , van de Heisteeg Damian , Herraez Alvaro , Plauschinn Erik
Published: August 2022

Abstract

The tadpole conjecture suggests that the complete stabilization of complex structure deformations in Type IIB and F-theory flux compactifications is severely obstructed by the tadpole bound on the fluxes. More precisely, it states that the stabilization of a large number of moduli requires a flux background with a tadpole that scales linearly in the number of stabilized fields. Restricting to the asymptotic regions of the complex structure moduli space, we give the first conceptual argument that explains this linear scaling setting and clarifies why it sets in only for a large number of stabilized moduli. Our approach relies on the use of asymptotic Hodge theory. In particular, we use the fact that in each asymptotic regime an orthogonal sl(2)-block structure emerges that allows us to group fluxes into sl(2)-representations and decouple complex structure directions. We show that the number of stabilized moduli scales with the number of sl(2)-representations supported by fluxes, and that each representation fixes a single modulus. Furthermore, we find that for Calabi-Yau four-folds all but one representation can be identified with representations occurring on two-folds. This allows us to discuss moduli stabilization explicitly and establish the relevant scaling constraints for the tadpole.
Epidemiology, patterns, and mechanisms of pediatric trauma: a review of 12,508 patients
Authors: Cintean Raffael , Eickhoff Alexander , Zieger Jasmin , Gebhard Florian , Schütze Konrad
Published: August 2022

Background

Pediatric traumas are common and remain a unique challenge for trauma surgeons. Demographic data provide a crucial source of information to better understand mechanisms and patterns of injury. The aim of this study was to provide this information to improve treatment strategies of potentially preventable morbidity and mortality in children.

Material and methods

A retrospective review of every pediatric trauma treated in the emergency department (ED) between 2015 and 2019 was performed. Inclusion criteria were the age between 0 and 14 years and admission to the ED after trauma. Demographic data, time of presentation, mechanism of injury and pattern of injury, treatment, and outcome were analyzed. Different injury patterns were assessed in relation to age group, sex, mechanism of injury and treatment.

Results

A total of 12,508 patients were included in this study. All patients were stratified into five age groups: babies under the age of 1 (8.8%), toddlers between 1 and 3 (16.8%), preschool children between 4 and 6 (19.3%), young school children between 7 and 10 (27.1%), and young adolescents between 11 and 14 (27.9%). The predominant sex in all age groups was male. 47.7% of patients were admitted between 4 and 10 pm; 14.8% of the patients arrived between 10 pm and 8 am. Peak months of admissions were May to July. Overall, 2703 fractures, 2924 lacerations and superficial tissue injury, 5151 bruises, 320 joint dislocations, 1284 distortions, 76 burns, and 50 other injuries were treated. Most common mechanisms for fractures were leisure activities, falls, and sports-related activities. Forearm fractures were the most common fractures (39.5%) followed by humerus fractures (14%) and fractures of the hand (12.5%). A total of 700 patients with fractures (25.9%) needed surgery. 8.8% of all patients were hospitalized for at least one day. 4 patients died in the hospital (0.03%).

Conclusion

Despite of higher risk, severe injuries in children are rare. Minor injuries and single fractures are common. Treatment should be managed in specialized centers to ensure an interdisciplinary care and fast recovery. Peak times in the late afternoon and evening and summer months should be taken into consideration of personnel planning.
Costimulatory molecule expression profile as a biomarker to predict prognosis and chemotherapy response for patients with small cell lung cancer
Authors: Wu Peng , Zhang Zhihui , Yang Zhaoyang , Zhang Chaoqi , Luo Yuejun , Zhang Guochao , Wang Lide , Xue Qi , Sun Nan , He Jie
Published: August 2022

Owing to the paucity of specimens, progress in identifying prognostic and therapeutic biomarkers for small cell lung cancer (SCLC) has been stagnant for decades. Considering that the costimulatory molecules are essential elements in modulating immune responses and determining therapeutic response, we systematically revealed the expression landscape and identified a costimulatory molecule-based signature (CMS) to predict prognosis and chemotherapy response for SCLCs for the first time. We found T cell activation was restrained in SCLCs, and costimulatory molecules exhibited widespread abnormal genetic alterations and expression. Using a LASSO Cox regression model, the CMS was built with a training cohort of 77 cases, which successfully divided patients into high- or low-risk groups with significantly different prognosis and chemotherapy benefit (both P < 0.001). The CMS was well validated in an independent cohort containing 131 samples with qPCR data. ROC and C-index analysis confirmed the superior predictive performance of the CMS in comparison with other clinicopathological parameters from different cohorts. Importantly, the CMS was confirmed as a significantly independent prognosticator for clinical outcomes and chemotherapy response in SCLCs through multivariate Cox analysis. Further analysis revealed that low-risk patients were characteristic by an activated immune phenotype with distinct expression of immune checkpoints. In summary, we firstly uncovered the expression heterogeneity of costimulatory molecules in SCLC and successfully constructed a novel predictive CMS. The identified signature contributed to more accurate patient stratification and provided robust prognostic value in estimating survival and the clinical response to chemotherapy, allowing optimization of treatment and prognosis management for patients with SCLC.
Sharp phase-field modeling of isotropic solidification with a super efficient spatial resolution
Authors: Fleck Michael , Schleifer Felix
Published: August 2022

The phase-field method provides a powerful framework for microstructure evolution modeling in complex systems, as often required within the framework of integrated computational materials engineering. However, spurious grid friction, pinning and grid anisotropy seriously limit the resolution efficiency and accuracy of these models. The energetic resolution limit is determined by the maximum dimensionless driving force at which reasonable model operation is still ensured. This limit turns out to be on the order of 1 for conventional phase-field models. In 1D, grid friction and pinning can be eliminated by a global restoration of Translational Invariance (TI) in the discretized phase-field equation. This is called the sharp phase-field method, which allows to choose substantially coarser numerical resolutions of the diffuse interface without the appearance of pinning. In 3D, global TI restricts the beneficial properties to a few specific interface orientations. We propose an accurate scheme to restore TI locally in the local interface normal direction. The new sharp phase-field model overcomes grid friction and pinning in three-dimensional simulations, and can accurately operate at dimensionless driving forces up to the order of $$10^{4}$$

10
4

. At one-grid-point interface resolutions, exceptional degrees of isotropy can be achieved, if further the largely inhomogeneous latent heat release at the advancing solid-liquid interface is mitigated. Imposing a newly proposed source term regularization, the new model captures the formation of isotropic seaweed structures without spurious dendritic selection by grid anisotropy, even at one-grid-point interface resolutions.
Out-of-field effects: lessons learned from partial body exposure
Authors: Pazzaglia S. , Eidemüller M. , Lumniczky K. , Mancuso M. , Ramadan R. , Stolarczyk L. , Moertl S.
Published: August 2022

Partial body exposure and inhomogeneous dose delivery are features of the majority of medical and occupational exposure situations. However, mounting evidence indicates that the effects of partial body exposure are not limited to the irradiated area but also have systemic effects that are propagated outside the irradiated field. It was the aim of the “Partial body exposure” session within the MELODI workshop 2020 to discuss recent developments and insights into this field by covering clinical, epidemiological, dosimetric as well as mechanistic aspects. Especially the impact of out-of-field effects on dysfunctions of immune cells, cardiovascular diseases and effects on the brain were debated. The presentations at the workshop acknowledged the relevance of out-of-field effects as components of the cellular and organismal radiation response. Furthermore, their importance for the understanding of radiation-induced pathologies, for the discovery of early disease biomarkers and for the identification of high-risk organs after inhomogeneous exposure was emphasized. With the rapid advancement of clinical treatment modalities, including new dose rates and distributions a better understanding of individual health risk is urgently needed. To achieve this, a deeper mechanistic understanding of out-of-field effects in close connection to improved modelling was suggested as priorities for future research. This will support the amelioration of risk models and the personalization of risk assessments for cancer and non-cancer effects after partial body irradiation.
Optimal fractional-order PID controller based on fractional-order actor-critic algorithm
Authors: Shalaby Raafat , El-Hossainy Mohammad , Abo-Zalam Belal , Mahmoud Tarek A.
Published: August 2022

In this paper, an online optimization approach of a fractional-order PID controller based on a fractional-order actor-critic algorithm (FOPID-FOAC) is proposed. The proposed FOPID-FOAC scheme exploits the advantages of the FOPID controller and FOAC approaches to improve the performance of nonlinear systems. The proposed FOAC is built by developing a FO-based learning approach for the actor-critic neural network with adaptive learning rates. Moreover, a FO rectified linear unit (RLU) is introduced to enable the AC neural network to define and optimize its own activation function. By the means of the Lyapunov theorem, the convergence and the stability analysis of the proposed algorithm are investigated. The FO operators for the FOAC learning algorithm are obtained using the gray wolf optimization (GWO) algorithm. The effectiveness of the proposed approach is proven by extensive simulations based on the tracking problem of the two degrees of freedom (2-DOF) helicopter system and the stabilization issue of the inverted pendulum (IP) system. Moreover, the performance of the proposed algorithm is compared against optimized FOPID control approaches in different system conditions, namely when the system is subjected to parameter uncertainties and external disturbances. The performance comparison is conducted in terms of two types of performance indices, the error performance indices, and the time response performance indices. The first one includes the integral absolute error (IAE), and the integral squared error (ISE), whereas the second type involves the rising time, the maximum overshoot (Max. OS), and the settling time. The simulation results explicitly indicate the high effectiveness of the proposed FOPID-FOAC controller in terms of the two types of performance measurements under different scenarios compared with the other control algorithms.
Using PFC2D to simulate the shear behaviour of joints in hard crystalline rock
Authors: Ríos-Bayona Francisco , Johansson Fredrik , Mas-Ivars Diego , Sánchez-Juncal Abel , Bolin Axel
Published: August 2022

Significant uncertainties remain regarding the assessment of the peak shear strength of rock joints. In recent years, Particle Flow Code (PFC) has been used to simulate shear tests of rock joints. Although previous studies showed PFC’s capability to simulate rock joint shear behaviour, it is uncertain how different parameters in PFC should be combined to realistically capture roughness and strength of asperities in contact of actual rock joints. Under low normal stresses, the shear behaviour of well-mated hard crystalline joints is governed by the interaction between asperities of some tenths of a millimetre. This paper investigates the capability of PFC2D to realistically simulate the peak shear strength of hard crystalline rock joints under different constant normal stress magnitudes. The simulated two-dimensional profiles were selected from the digitised joint surface obtained with optical scanning measurements. To realistically capture surface roughness and asperity strength in PFC2D, different values of joint segment length, particle resolution per segment, and bond strength between particles were studied and calibrated while taking into account the laboratory observations. The results of the numerical simulations in the PFC2D environment show that the simulated peak shear strength using the profile containing the steepest asperity is in good agreement with that measured in the laboratory. The joint profile needs to be represented by both a magnitude of segment length that captures the grain size, and at least two particles per segment. The bond strength calibration needs to account for both asperity size and the number of particles in contact during shearing.
Utilization of gold nanoparticles for the detection of squamous cell carcinoma of the tongue based on laser-induced fluorescence and diffuse reflectance characteristics: an in vitro study
Authors: Nour Maha , Hamdy Omnia , Faid Amna H. , Eltayeb Elsayed Abdallah , Zaky Ahmed Abbas
Published: August 2022

Squamous cell carcinoma is a very common type of oral cancer that affects the health of people with an unacceptably high mortality rate attributed to the difficulties in detecting the disease at an early stage. Therefore, effective techniques for early diagnosis and effective therapy of oral cancer are necessary. In the present study, we exploit the ability of gold nanoparticles (AuNPs) to undergo coupled surface plasmon resonance when closely spaced to improve diagnosing squamous cell carcinoma of the tongue. The prepared AuNPs are characterized by UV–VIS spectroscopy, dynamic light scattering, Fourier transform infrared spectroscopy, and transmission electron microscopy. The size of the prepared AuNPs is 12 ± 2 nm with narrow size distributions and exhibited high stability with a zeta potential of − 16.5 mV. The light fluorescence of the normal and cancer cells is recorded before and after NP addition using a spectrometer upon excitation by 405-nm laser irradiation. Furthermore, the light reflectance of the examined samples is measured at different laser wavelengths (red to NIR region). The obtained results show that the cancer cells mixed with AuNPs produce a higher fluorescence peak at 489.2 nm than the cancer cells without AuNPs. Moreover, the optical diffuse reflectance analyses reveal that the addition of AuNPs enhances cancer detection especially at the 635-nm irradiation with sensitivity (94%), specificity (87%), and overall accuracy (91%).
Sperm culture and bacterial susceptibility to antibiotics in a large andrological population: prevalence and impact on seminal parameters
Authors: Olana Soraya , Mazzilli Rossella , Santino Iolanda , Martinelli Daniela , Zamponi Virginia , Macera Manuela , Salerno Gerardo , Mazzilli Fernando , Faggiano Antongiulio , Gianfrilli Daniele
Published: August 2022

Background

The aim of this study was to evaluate (i) the prevalence of subjects with a positive sperm culture (SC) for bacteria in subjects with or without genitourinary tract inflammation (GTI); (ii) the actual distribution of the species analysed, according to Gram stain; (iii) the impact on sperm parameters; and (iv) the actual bacterial susceptibility to antibiotics.

Methods

A total of 930 subjects (18–55) years, were retrospectively studied. All the patients underwent SC and in the case of positive tests (CFU > 106), a microbiological susceptibility analysis. The subjects studied were subdivided into group A (n = 452), with subjective signs of GTI; group B (n = 478), male partners of infertile couples; and group C, 30 healthy normospermic subjects. In group B and in the control group, a semen analysis was performed.

Results

Overall, the prevalence of positive SC was 21.5% (200/930). The prevalence of positive SC in group A (113/200; 56.5%) was significantly higher vs. group B (87/200; 43.5%; p = 0.01) and control group (1/30; 3.3%; p = 0.0001). In subjects with GTI, the prevalence of asthenozoospermic (96/285; 33.7%) and oligo-asthenozoospermic (98/285; 34.4%) was significantly higher vs. normospermic, oligo-astheno-teratozoospermic, oligozoospermic and azoospermic subjects (22/285 (7.7%), 48/285 (16.8%), 15/285 (5.3%) and 6/285 (2.1%), respectively; p = 0.001). Finally, Enterococcus faecalis (Gram-positive) and Escherichia coli (Gram-negative) showed the highest prevalence of antibiotic resistance.

Conclusions

The prevalence of positive SC is higher in GTI subjects; however, the SC could also be positive in subjects without GTI. Commonly used antibiotics have an increasing risk of being useless for the treatment of bacterial infections. Finally, the diagnosis of GTIs is important also for male fertility.
Drop Test Kinematics Using Varied Impact Surfaces and Head/Neck Configurations for Rugby Headgear Testing
Authors: Stitt Danyon , Kabaliuk Natalia , Alexander Keith , Draper Nick
Published: August 2022

World Rugby employs a specific drop test method to evaluate headgear performance, but almost all researchers use a different variation of this method. The aim of this study was, therefore, to quantify the differences between variations of the drop testing method using a Hybrid III headform and neck in the following impact setups: (1) headform only, with a flat steel impact surface, approximating the World Rugby method, (2 and 3) headform with and without a neck, respectively, onto a flat MEP pad impact surface, and (4) headform and neck, dropped onto an angled MEP pad impact surface. Each variation was subject to drop heights of 75–600 mm across three orientations (forehead, side, and rear boss). Comparisons were limited to the linear and rotational acceleration and rotational velocity for simplicity. Substantial differences in kinematic profile shape manifested between all drop test variations. Peak accelerations varied highly between variations, but the peak rotational velocities did not. Drop test variation also significantly changed the ratios of the peak kinematics to each other. This information can be compared to kinematic data from field head impacts and could inform more realistic impact testing methods for assessing headgear.
Relationship Power, Antiretroviral Adherence, and Physical and Mental Health Among Women Living with HIV in Rural Kenya
Authors: Burger Rachel L. , Cohen Craig R. , Mocello A. Rain , Dworkin Shari L. , Frongillo Edward A. , Weke Elly , Butler Lisa M. , Thirumurthy Harsha , Bukusi Elizabeth A. , Weiser Sheri D.
Published: August 2022

Little is known about the association of gender-based power imbalances and health and health behaviors among women with HIV (WWH). We examined cross-sectional baseline data among WWH in a cluster-randomized control trial (NCT02815579) in rural Kenya. We assessed associations between the Sexual Relationship Power Scale (SRPS) and ART adherence, physical and mental health, adjusting for sociodemographic and social factors. SRPS consists of two subscales: relationship control (RC) and decision-making dominance. Women in the highest and middle tertiles for RC had a 7.49 point and 8.88 point greater Medical Outcomes Study-HIV mental health score, and a 0.27 and 0.29 lower odds of depression, respectively, compared to women in the lowest tertile. We did not find associations between SPRS or its subscales and ART adherence. Low sexual relationship power, specifically low RC, may be associated with poor mental health among WWH. Intervention studies aimed to improve RC among WWH should be studied to determine their effect on improving mental health.
Stochastic tramp ship routing with speed optimization: analyzing the impact of the Northern Sea Route on $$\mathrm {CO_2}$$ emissions
Authors: Li Mingyu , Fagerholt Kjetil , Schütz Peter
Published: August 2022

To address the decarbonization challenge, we consider a tramp ship routing problem with speed optimization where the availability of future cargoes is uncertain. We propose a two-stage stochastic programming model to solve it. The first stage of the model decides on the deterministic cargoes with the known availability, while the second stage decides on the detailed routing and scheduling plans with the available spot cargoes revealed. Since sailing speed heavily influences on the fuel consumption, and hence costs and emissions, we include the ships’ speeds along the different sailing legs as decision variables. The opening of the Northern Sea Route (NSR) provides a shorter alternative in connecting Asia and Europe, which may benefit the shipping industry in reducing $$\mathrm {CO_2}$$

CO
2

emissions. We use our model to evaluate the impact of NSR on $$\mathrm {CO_2}$$

CO
2

emissions in tramp shipping considering speed optimization and possible future carbon tax schemes, such as fixed and progressive carbon taxes. The computational results indicate that using the NSR improves the gross margins and reduces the $$\mathrm {CO_2}$$

CO
2

emissions for tramp operators.
Responsible innovation and ethical corporate behavior in the Asian fashion industry: A systematic literature review and avenues ahead
Authors: Di Vaio Assunta , Hassan Rohail , D’Amore Gabriella , Tiscini Riccardo
Published: August 2022

Fashion firms have transferred their manufacturing processes to Asia, seeking minimum labor costs, supported by the academic literature’s proposals for alternative supply chain configurations to maximize profits. Fashion industry has undergone public analysis, facing demands for greater transparency about environmental and social sustainability. The growing public awareness of sustainability issues has led firms to declare their commitment to sustainable resources, but few changes have been registered. United Nations Economic Commission for Europe listed technological innovation as a key tool for making the fashion industry transparent and traceable regarding sustainability and circularity. The research and responsible innovation framework indicate appropriate ways to manage innovation from a responsible and ethical perspective, according to ethical corporate behaviour (ECB), particularly in the industries characterized by productive phases processed in more countries, such as the fashion industry. However, the linkages between responsible innovation, ECB towards innovative and sustainable business models, and their conceptualization, are still unclear in the fashion industry, achieving the goals included in the UN 2030 Agenda. This study draws on bibliometric analysis and systematic review of the literature on 114 articles published between 1990 and 2021 allows to identify the above issues in the research domains, and outline the evolutionary trajectories, as well as to explore the literary corpus about responsible innovation (RI) in the ethical corporate behaviour (ECB) of the fashion industry and its Asian suppliers. The results highlight that fashion brands strive to develop RI and ECB along their supply chain. Still, the misalignment of corporate ethics and cultural values represents a significant obstacle to the adoption of business models, especially to achieve the goals of UN 2030 Agenda. To the best of our knowledge, this is the first study that discusses RI as enabling driver in the ECB for fashion companies also defining a future research agenda including RI, ECB, iSBMs towards SDGs.
Political polarization in the UK: measures and socioeconomic correlates
Authors: Grechyna Daryna
Published: August 2022

This paper evaluates the political polarization in the UK and analyzes its socioeconomic correlates based on detailed county-level panel data constructed from the British Household Panel Survey. Three different polarization measures, computed following different strands of the literature, are highly correlated and characterized by similar statistical properties, which implies they can be used interchangeably in the quantitative analysis. The empirical evaluation of the determinants of political polarization suggests that regional political polarization in the UK is positively associated with the variability of job status and negatively associated with an increase in the employment rate and an increase in the share of natives in the region. The findings of this paper fill the gaps in understanding the political polarization in the UK by clarifying its measurement, correlates, and trends.
Between the legal technique and the social question: the plural commitments of public defenders in Argentina
Authors: Ciocchini Pablo , Kostenwein Ezequiel
Published: August 2022

The criminal process in the Province of Buenos Aires has been affected by radical reforms in the last decades. Beginning with the complete replacement of the criminal procedure code in 1998 to the introduction of pre-trial hearings and simplified procedures for cases declared in flagrante delicto in 2004 the reforms have impacted more than legal procedures; they have changed the way judicial actors perceive themselves and their relations with the institution. Based on interviews with ten public defenders of the PBA this article offers an exploratory analysis on how public defenders’ perceptions have been impacted by those reforms and to what extent those internal changes have affected the internal dynamics of the PD. Drawing from the sociology of Bernard Lahire and Laurent Thenevot we identify in the public defenders’ responses how these changes affected their personal commitments. Mapping those commitments allow us to describe the subjective folds of the PD through which it is possible to better understand the decisions of public defenders by considering the internalization they make of the judicial world and its relationship with the institutional context.
Profiles of doctoral students’ experience of ethics in supervision: an inter-country comparison
Authors: Löfström Erika , Peltonen Jouni , Frick Liezel , Niglas Katrin , Pyhältö Kirsi
Published: August 2022

The purpose of this study was to examine variation in doctoral students’ experiences of ethics in doctoral supervision and how these experiences are related to research engagement, burnout, satisfaction, and intending to discontinue PhD studies. Data were collected from 860 doctoral students in Finland, Estonia, and South Africa. Four distinct profiles of ethics experience in doctoral supervision were identified, namely students puzzled by the supervision relationship, strugglers in the ethical landscape, seekers of ethical allies, and students with ethically trouble-free experiences. The results show that the profiles were related to research engagement, satisfaction with supervision and studies, and burnout. Not experiencing any major ethical problems in supervision was associated with experiencing higher engagement and satisfaction with supervision and doctoral studies and low levels of exhaustion and cynicism. Similar profiles were identified across the countries, yet with different emphases. Both Estonian and South African PhD students were overrepresented in the profile of students with ethically trouble-free experiences, while the Finnish students were underrepresented in this profile. The Finnish PhD students were overrepresented among the seekers of ethical allies. Profiles provide information that can alert supervisors and administrators about the extent of the risk of burnout or discontinuing of PhD studies based on students’ negative experiences of the ethics in supervision.
Demographic, clinical and tomographic characteristics of pellucid marginal degeneration patients in South Egyptian population
Authors: Mounir Amr , Abdellah Marwa Mahmoud , Awny Islam , Aldghaimy Ahmed Hassan , Mostafa Engy Mohamed
Published: August 2022

Purpose

To retrospectively evaluate the demographic, clinical, and tomographic characteristics of pellucid marginal degeneration (PMD) patients in South Egypt.

Methods

This study was retrospective cross-sectional, including all patients who attended and sought refractive surgery at Sohag Center for Corneal and Refractive Surgeries, Sohag, South Egypt, between October 2016 and October 2020, and had a diagnosis of PMD. It included cases of PMD at different stages. Cases with PMD were diagnosed by the two authors (experienced in corneal refractive surgery), combining both slit-lamp biomicroscopy findings and corneal tomography.

Results

Out of the 2534 patients attending the Sohag Center for Corneal and Refractive Surgeries (between October 2016 and May 2020) seeking correction of their refractive errors, 24 patients were found to fit in the diagnosis of PMD. Forty-three eyes of the 24 patients were diagnosed with PMD. The topographic patterns ranged from horizontal bow tie (against the rule astigmatism) being the least presenting, followed by crab claw, then butterfly pattern.

Conclusion

PMD is a separate entity of the ectatic corneal spectrum that can easily be misinterpreted as Keratoconus. Topographic and tomographic patterns cannot solely diagnose PMD as they should be enforced by slit-lamp findings.
Christian Junge – a pioneer in global atmospheric chemistry
Authors: Duce Robert A. , Dickerson Russell R. , Galbally Ian E. , Galloway James N. , Jaenicke Ruprecht , Keene William C. , Lelieveld Jos , Levy Hiram , Prospero Joseph M. , Schütz Lothar , Slemr Franz , Winkler Peter
Published: August 2022

Christian Junge (1912–1996) is considered by many to be the founder of the modern discipline of atmospheric chemistry. In studies from the 1950s through the 1970s, Junge was able to link chemical measurements in a few scattered locations around the earth and integrate them with meteorology to develop the first global view of the basic chemical and physical processes that control the sources, transport, transformations, and fate of particles and gases in the atmosphere. In this paper we summarize and comment upon a number of Junge’s seminal research contributions to atmospheric chemistry, including his discovery of the stratospheric sulfate layer (known as the Junge layer), his recognition of the relationship between the variability of the concentrations of trace gases and their atmospheric lifetimes, his studies of aerosol size and number distributions, his development of the first quantitative model of tropospheric ozone, and other significant scientific investigations. We also discuss Junge’s professional life, his many international leadership positions and honors, as well as some memories and reflections on his many abilities that led to his outstanding contributions to the science of atmospheric chemistry.
A Least-Squares Method for the Solution of the Non-smooth Prescribed Jacobian Equation
Authors: Caboussat Alexandre , Glowinski Roland , Gourzoulidis Dimitrios
Published: August 2022

We consider a least-squares/relaxation finite element method for the numerical solution of the prescribed Jacobian equation. We look for its solution via a least-squares approach. We introduce a relaxation algorithm that decouples this least-squares problem into a sequence of local nonlinear problems and variational linear problems. We develop dedicated solvers for the algebraic problems based on Newton’s method and we solve the differential problems using mixed low-order finite elements. Various numerical experiments demonstrate the accuracy, efficiency and the robustness of the proposed method, compared for instance to augmented Lagrangian approaches.
Production of Bio-composite Films from Gum Arabic and Galangal Extract to Prolong the Shelf Life of Agaricus bisporus
Authors: Gomaa Maha M. , Fadly Enas El. , Salama Mohamed Abdelbaset , Abdin Mohamed
Published: August 2022

The current study was performed to develop biodegradable films with matrix composed from gum Arabic (GA) and different concentrations from Alpinia officinarum phenolic extract (AOE). The color indices, physical properties, surface shape, crystallinity, mechanical properties and thermal stability of produced films were investigated. The incorporation of AOE extract (0.25 g/100 mL) inside GA films increased dark yellow color, reduced moisture, swelling, solubility and water vapor permeability (WVP) of films up to 10.29%, 21.05%, 14.15% and 4.20 × 10−10 g H2O/m s p.a., respectively. Furthermore, the scanning electron micrographs showed uniform structure with rough surface and turmoil spots in the structure by increasing AOE concentration inside films. The FT-IR analysis showed typically bands that proved physical interaction between AOE extract and GA polymer. The fabricated films showed satisfied thermal stability manners with declining trend by incorporation of AOE inside GA films. Furthermore, the developed films showed significant effects on reducing the changes of browning index from 17.20 to 24.54 and firmness from 33.98 to 22.65 N of Agaricus bisporus caps during storage days compared with commercial packaging materials.
Between Presence and Commitment: A Qualitative Exploratory Study of People with Visual Impairment in Polish Religious Communities
Authors: Maciejewska Magdalena
Published: August 2022

This article aims to identify factors that may be important in the inclusion process of people with disabilities in religious communities. This text was based upon the interviews conducted with 10 respondents who belonged to Christian communities. They were characterised by a diverse approach, and are therefore referred to in this article as spiritual settlers, spiritual pilgrims and spiritual wanderers. These were then associated with theoretical terms such as presence, affiliation and commitment, to analyse the procedures of the respondents' self-reported functioning in these religious communities.
Extraction of uranium and copper from acid leached solid waste of Alluoga sedimentary rocks, Southwestern Sinai, Egypt
Authors: Attia Reda M.
Published: August 2022

A solid waste sample from acidic leaching of Alluoga sedimentary rocks, SW Sinai, Egypt, was processed for leaching and extraction of U and Cu respectively. This sample assayed 200 mg/kg U and 5 g/kg Cu. The present work aims to obtain solid waste free of U and Cu through selective alkaline leaching for uranium followed by environmentally safe glycine solution for copper leaching from the resulted waste. Under studied optimum conditions the leaching efficiency of U and Cu attained 93% and 96% respectively. Uranium was extracted using Amberlite IRA-400 Anion exchanger while Cu was selective extracted by LIX-973N diluted in kerosene. The relevant factors affecting the Cu extraction process were adequately studied and the number of stages for extraction and stripping were determined by the construction of McCabe–Thiele diagram.
Passive thermal control design and analysis of a university-class satellite
Authors: Elhefnawy Ahmed , Elmaihy Ali , Elweteedy Ahmed
Published: August 2022

This paper describes the passive thermal control analysis and design for a small satellite in low Earth orbit. The main objective of the thermal control system is to guarantee the proper operation against the harsh environment in space.

The European Student Earth Orbiter satellite was chosen to carry out this study. The paper introduces an alternative means for the thermal control system to be passive by using tapes, coatings, radiators, and multi-layer insulation applied to the satellite to control radiation heat exchange between the satellite and its environment. For this purpose, a finite-difference model was developed using a commercial software package. Results obtained from the simulations were introduced, analyzed, and partially verified for both extreme hot and cold cases.

The results show that all the components inside the satellite, structural, and solar panels were within their temperature limits. The most critical components in the hot case are the battery and gyro box with temperature safety margins of 1.83 °C and 2.47 ℃, respectively. The most critical components in the cold case are reaction wheel 2 and uCAM with temperature safety margins of 4.62 ℃ and 4.73 ℃, respectively. The battery on panel 6 has a temperature safety margin of 6.64 ℃.
Processes taking place during the preparation and use of electrospun PLA fibers and their effect on controlled drug release
Authors: Yi Lan , Luo Sheng , Cui Lu , Budai-Szűcs Mária , Móczó János , Pukánszky Béla
Published: August 2022

PLA fibers containing metronidazole as the active component were produced by electrospinning from a solvent mixture of dichloromethane (DCM) and dimethyl sulfoxide (DMSO). The DMSO content of the spinning solution changed between 0 and 25 vol% in 5 vol% steps. The fibers were dried at different temperatures, and processes taking place during fiber production and drying were followed by thermogravimetric analysis and differential scanning calorimetry. The morphology and structure of the fibers were studied by microscopy and X-ray diffraction. The mechanical properties of fiber mats and the release of the drug were also determined as a function of processing and drying parameters. The results showed that several processes take place during the production and subsequent handling of the fibers including the evaporation of the solvent (DMSO), the crystallization of the polymer, the changing of composition, phase separation and the consequent partitioning of the drug. The crystalline structure of the fibers changes considerably during drying which determines their mechanical properties. The rate of evaporation and crystallization is in the same order of magnitude. The rate of both processes increases considerably with temperature, but does not depend strongly on the amount of DMSO in the spinning solution. Both the amount of the drug released and the rate of release cover a wide range depending on the parameters of the preparation technology. The large range of mechanical and functional properties obtained allows the control of the kinetics of drug release to some extent.
Free Choice in Modal Inquisitive Logic
Authors: Nygren Karl
Published: August 2022

This paper investigates inquisitive extensions of normal modal logic with an existential modal operator taken as primitive. The semantics of the existential modality is generalized to apply to questions, as well as statements. When the generalized existential modality is applied to a question, the result is a statement that roughly expresses that each way of resolving the question is consistent with the available information. I study the resulting logic both from a semantic and from a proof-theoretic point of view. I argue that it can be used for reasoning about a general notion of ignorance, and for reasoning about choice-offering permissions and obligations. The main technical results are sound and complete axiomatizations, both for the class of all Kripke frames, and for any class of frames corresponding to a canonical normal modal logic.
Neutral Free Logic: Motivation, Proof Theory and Models
Authors: Pavlović Edi , Gratzl Norbert
Published: August 2022

Free logics are a family of first-order logics which came about as a result of examining the existence assumptions of classical logic (HintikkaThe Journal of Philosophy,56, 125–137 1959; LambertNotre Dame Journal of Formal Logic,8, 133–144 1967, 1997, 2001). What those assumptions are varies, but the central ones are that (i) the domain of interpretation is not empty, (ii) every name denotes exactly one object in the domain and (iii) the quantifiers have existential import. Free logics reject the claim that names need to denote in (ii).Positivefree logic concedes that some atomic formulas containing non-denoting names (including self-identity) are true,negativefree logic treats them as uniformly false, andneutralfree logic as taking a third value. There has been a renewed interest in analyzing proof theory of free logic in recent years, based on intuitionistic logic in Maffezioli and Orlandelli (Bulletin of the Section of Logic,48(2), 137–158 2019) as well as classical logic in Pavlović and Gratzl (Journal of Philosophical Logic,50, 117–148 2021), there for the positive and negative variants. While the latter streamlines the presentation of free logics and offers a more unified approach to the variants under consideration, it does not cover neutral free logic, since there is some lack of both clear formal intuitions on the semantic status of formulas with empty names, as well as a satisfying account of the conditional in this context. We discuss extending the results to this third major variant of free logics. We present a series of G3 sequent calculi adapted from Fjellstad (Studia Logica,105(1), 93–119 2017,Journal of Applied Non-Classical Logics,30(3), 272–289 2020), which possess all the desired structural properties of a good proof system, including admissibility of contraction and all versions of the cut rule. At the same time, we maintain the unified approach to free logics and moreover argue that greater clarity of intuitions is achieved once neutral free logic is conceptualized as consisting of two sub-varieties.
Improving Knowledge and Attitudes About Child Trauma Among Parents and Staff in Head Start Programs
Authors: Guerrero A. , Herman A. , Teutsch C. , Dudovitz R.
Published: August 2022

Background

Early childhood represents a sensitive developmental period when trauma-informed care may mitigate the effects of trauma on developmental and health outcomes. However, few interventions use a low-literacy scalable approach to improve child trauma knowledge and attitudes among parents and early childcare and education caregivers.

Methods

Representatives from 24 early head start (EHS) and head start (HS) agencies attended a 2 day online train-the trainer session and then delivered a child trauma and resilience training to staff at their sites, with the option to deliver a similar training to parents. Baseline and 3 month post-training surveys assessed participant knowledge and attitudes regarding childhood trauma and resilience. Paired T-tests and chi2 analyses assessed changes in responses over time.

Results

Thousand five hundred sixty seven staff from 24 agencies and 443 parents from 7 agencies completed baseline and follow up surveys. Over 55% of parents reported their child had experienced at least one adverse childhood experience. Staff and parents had high knowledge regarding causes of trauma at baseline. Both staff and parents, demonstrated significant improvements in identifying symptoms of child trauma. Staff also improved knowledge of resiliency and toxic stress. Parents reported more positive attitudes towards trauma-informed parenting practices.

Conclusion

This is the first training on childhood trauma among EHS/HS providers and parents using a low literacy train-the-trainer approach. Results suggest a potentially promising methodology with broad dissemination potential to prepare and train the one million plus teachers and caregivers in center-based settings and the parents and families who access them to recognize and respond to child trauma.
Synovial fibroblast-miR-214-3p-derived exosomes inhibit inflammation and degeneration of cartilage tissues of osteoarthritis rats
Authors: Lai Chenteng , Liao Boyi , Peng Song , Fang Peng , Bao Nirong , Zhang Lei
Published: August 2022

MicroRNAs (miRs) are regulators of number of cellular process. miRs enclosed within exosomes can be crucial regulators of intercellular signalling and could be an important biomarker of various age-associated disorders. Role of exosomal enclosed miRs in osteoarthritis (OA) chondrocytes and synovial fibroblasts (SFBs) remains poorly studied. Here, we profiled and studied the effect of synovial fluid-derived exosomal miRs on inflammation, survival, proliferation of chondrocyte in correlation with cartilage degeneration. Exosomes were isolated from synovial fluid collected from OA subjects and were analysed by transmission electron microscopy. miRs were isolated and were submitted to microarray profiling. Web-based PCR analysis was done. Chondrocyte proliferation and colony formation assay were performed. Apoptosis study was done by flow cytometer. Gene expression was done by qRT-PCR analysis and protein expression by western blot assay. Rat model of OA was created by operating the knee by anterior cruciate ligament and resection of medial menisci (ACLT + MMx) method. Micro-CT analysis, histological analysis, immunohistochemical staining, and TUNEL assay were also performed. About 17 miRs were found to be expressed differentially in the synovial fluid collected from the control and OA subjects. Microarray analysis confirmed, expression of miR-214-3p was significantly downregulated in the synovial fluid exosome of OA subjects. miR-214-3p mimic promoted proliferation of chondrocyte and suppressed apoptosis. Treatment also inhibited the levels of TNF-α, IL-1β and IL-6. SFB-miR-214-3p exosomes suppressed apoptosis and also inflammation in chondrocytes. In vivo study suggested that SFB-exosomal miR-214-3p from rats suppressed the formation of osteophytes, prevented degeneration of cartilage and exerted anti-inflammatory and anti-apoptotic effect in articular cartilage tissue. The findings suggested that SFB-miR-214-3p exosomes can ameliorate chondrocyte inflammation and degeneration of cartilage tissues. The study confirms therapeutic potential of SFB-miR-214-3p exosomes in treating OA.