bluuebunny/crossref_metadata_2025 huggingface dataset:
Disease Progression in Charcot–Marie–Tooth Disease Related to MPZ Mutations: A Longitudinal Study
Authors: Fridman Vera , Sillau Stefan , Bockhorst Jacob , Smith Kaitlin , Moroni Isabella , Pagliano Emanuela , Pisciotta Chiara , Piscosquito Guiseppe , Laurá Matilde , Muntoni Francesco , Bacon Chelsea , Feely Shawna , Grider Tiffany , Gutmann Laurie , Shy Rosemary , Wilcox Janel , Herrmann David N. , Li Jun , Ramchandren Sindhu , Sumner Charlotte J. , Lloyd Thomas E. , Day John , Siskind Carly E. , Yum Sabrina W. , Sadjadi Reza , Finkel Richard S. , Scherer Steven S. , Pareyson Davide , Reilly Mary M. , Shy Michael E. ,   the Inherited Neuropathies Consortium–Rare Diseases Clinical Research Network
Published: October 2022

Objective

The paucity of longitudinal natural history studies in MPZ neuropathy remains a barrier to clinical trials. We have completed a longitudinal natural history study in patients with MPZ neuropathies across 13 sites of the Inherited Neuropathies Consortium.

Methods

Change in Charcot–Marie–Tooth Examination Score (CMTES) and Rasch modified CMTES (CMTES‐R) were evaluated using longitudinal regression over a 5‐year period in subjects with MPZ neuropathy. Data from 139 patients with MPZ neuropathy were examined.

Results

The average baseline CMTES and CMTES‐R were 10.84 (standard deviation [SD] = 6.0, range = 0–28) and 14.60 (SD = 7.56, range = 0–32), respectively. A mixed regression model showed significant change in CMTES at years 2–5 (mean change from baseline of 0.87 points at 2 years, p = 0.008). Subgroup analysis revealed greater change in CMTES at 2 years in subjects with axonal as compared to demyelinating neuropathy (mean change of 1.30 points [p = 0.016] vs 0.06 points [p = 0.889]). Patients with a moderate baseline neuropathy severity also showed more notable change, by estimate, than those with mild or severe neuropathy (mean 2‐year change of 1.14 for baseline CMTES 8–14 [p = 0.025] vs −0.03 for baseline CMTES 0–7 [p = 0.958] and 0.25 for baseline CMTES ≥ 15 [p = 0.6897]). The progression in patients harboring specific MPZ mutations was highly variable.

Interpretation

CMTES is sensitive to change over time in adult patients with axonal but not demyelinating forms of MPZ neuropathy. Change in CMTES was greatest in patients with moderate baseline disease severity. These findings will inform future clinical trials of MPZ neuropathies. ANN NEUROL 2023;93:563–576
Massless Dirac Fermions on a Space‐Time Lattice with a Topologically Protected Dirac Cone
Authors: Donís Vela A. , Pacholski M. J. , Lemut G. , Tworzydło J. , Beenakker C. W. J.
Published: October 2022

The symmetries that protect massless Dirac fermions from a gap opening may become ineffective if the Dirac equation is discretized in space and time, either because of scattering between multiple Dirac cones in the Brillouin zone (fermion doubling) or because of singularities at zone boundaries. Here an implementation of Dirac fermions on a space‐time lattice that removes both obstructions is introduced. The quasi‐energy band structure has a tangent dispersion with a single Dirac cone that cannot be gapped without breaking both time‐reversal and chiral symmetries. It is shown that this topological protection is absent in the familiar single‐cone discretization with a linear sawtooth dispersion, as a consequence of the fact that there the time‐evolution operator is discontinuous at Brillouin zone boundaries.
Selective Biocatalytic N‐Methylation of Unsaturated Heterocycles
Authors: Ospina Felipe , Schülke Kai H. , Soler Jordi , Klein Alina , Prosenc Benjamin , Garcia‐Borràs Marc , Hammer Stephan C.
Published: October 2022

Methods for regioselective N‐methylation and ‐alkylation of unsaturated heterocycles with “off the shelf” reagents are highly sought‐after. This reaction could drastically simplify synthesis of privileged bioactive molecules. Here we report engineered and natural methyltransferases for challenging N‐(m)ethylation of heterocycles, including benzimidazoles, benzotriazoles, imidazoles and indazoles. The reactions are performed through a cyclic enzyme cascade that consists of two methyltransferases using only iodoalkanes or methyl tosylate as simple reagents. This method enables the selective synthesis of important molecules that are otherwise difficult to access, proceeds with high regioselectivity (r.r. up to >99 %), yield (up to 99 %), on a preparative scale, and with nearly equimolar concentrations of simple starting materials.
Transient Stabilization Effect of CO2 in the Electrochemical Hydrogenation of Azo Compounds and the Reductive Coupling of α‐Ketoesters
Authors: Zhao Yulei , Guo Xuqiang , Li Shuai , Fan Yuhang , Ji Guo‐Cui , Jiang Mengmeng , Yang Yin , Jiang Yuan‐Ye
Published: October 2022

The carbon dioxide (CO2) capture and utilization has attracted a great attention in organic synthesis. Herein, an unpresented transient stabilization effect (TSE) of CO2 is disclosed and well applied to the electrochemical hydrogenation of azo compounds to hydrazine derivatives. Mechanistic experiments and computational studies imply that CO2 can capture azo radical anion intermediates to protect the hydrogenation from potential degradation reactions, and is finally released through decarboxylation. The promotion effect of CO2 was further demonstrated to work in the preliminary study of electrochemical reductive coupling of α‐ketoesters to vicinal diol derivatives. For the electrochemical reductive reactions mentioned above, CO2 is indispensable. The presented results shed light on a different usage of CO2 and could inspire novel experimental design by using CO2 as a transient protecting group.
Graphene Nanoribbon Hybridization of Zeolitic Imidazolate Framework Membranes for Intrinsic Molecular Separation
Authors: Choi Eunji , Choi Ji Il , Kim Yong‐Jae , Kim Yeong Jae , Eum Kiwon , Choi Yunkyu , Kwon Ohchan , Kim Minsu , Choi Wooyoung , Ji Hyungjoon , Jang Seung Soon , Kim Dae Woo
Published: October 2022

Zeolitic imidazolate frameworks (ZIFs) are promising for gas separation membrane, but their molecular cut‐off differs from that expected from its intrinsic aperture structure because of their flexibility. Herein, we introduced graphene nanoribbons (GNRs) to rigidify the ZIF framework. Because the sp2 edge of the GNRs induces strong anchoring effects, the modified layer can be rigidified. Particularly, when the GNRs were embedded and distributed in the ZIF‐8 layer, an intrinsic aperture size of 3.4 Å was observed, resulting in high H2/CO2 separation (H2 permeance: 5.2×10−6 mol/m2 Pa s, ideal selectivity: 142). The performance surpasses the upper bound of polycrystalline MOF membrane performance. In addition, the membrane can be applied to blue H2 production, as demonstrated with a simulated steam reformed gas containing H2/CO2/CH4. The separation performance was retained in the presence of water. The fundamentals of the molecular transport through the rigid ZIF‐8 framework were revealed using molecular dynamics simulations.
Recent Advances in Activatable 19F Magnetic Resonance Imaging Nano‐Probes for the Detection of Biomarkers
Authors: Salaam Jeremy , Minoshima Masafumi , Kikuchi Kazuya
Published: October 2022

Adapting MRI to the field of molecular imaging is a challenge that continues to attract considerable attention. The detection of a given biomolecular analyte requires the availability of a molecular probe that is able to respond with a sufficient signal gap in order to overcome the low sensitivity of MRI. To this end, 19F MRI has yielded promising results due to its negligible endogenous background signals. Several small molecular probes have been reported; however, the low sensitivity of 19F MRI render the detection of biomarkers in vivo difficult, in view of their sub‐nanomolar concentration on site. Researchers have thus directed their attention toward larger chemical objects containing large numbers of 19F nuclei as smart platforms that allow a stimuli‐induced response. This article discusses the recent advances and future directions in the design of nano‐probes that respond to chemical or physical stimuli recognized as biomarkers for life and disease.
Improvement of coagulating strength and toughness of alkoxysilanes for conservation of cultural heritage
Authors: Nakamura Yoshinobu , Nagao Asuha , Kontani Ryo , Nakane Yuta , Nakamura Takashi , Tsuruta Hiroaki , Suemori Kaoru , Suita Hiroshi , Hirai Tomoyasu , Fujii Syuji
Published: October 2022

The optimal restoration agent for the brittle walls of Idout's tomb built 4400 years ago in Saqqara, Egypt, which is located underground in a desert area, was investigated. From x‐ray diffraction analysis of the sand collected near the tomb, the main ingredient is silica. Alkoxysilane and its oligomer are used because its alkoxy groups can react readily with silica. The compressive test of solidified model sand its main component is silica was done. The increase of both molecular weight of oligomer and the content of oligomer with higher molecular weight effectively developed the compressive force. When an earthquake occurs, it is desirable that the reinforced wall will be crushed in ductility. The addition of di‐alkoxy type alkoxysilane to oligomers changed the failure mode from brittle to ductile, because the network becomes looser. When a moderate quantity of di‐alkoxy type is added to oligomers, the solidified model sand deforms with greater displacement, while maintaining a high compressive force. From scanning electron microscopic observation of fractured solidified specimen, alkoxysilane was making the sand particles connect as a binder. Many cracks were clearly observed in the binder layer. Whereas, the formed crack was far smaller for di‐alkoxy added system.
Elevated‐temperature mechanical performance of GFRP composite with functionalized hybrid nanofiller
Authors: De Soubhik , Nuli Krishna Chaitanya , Fulmali Abhinav Omprakash , Behera Priyadarhi , Prusty Rajesh Kumar
Published: October 2022

In this article, alteration in the mechanical performance of glass fiber/epoxy (GE) composite due to individual and simultaneous incorporation of multi‐walled carbon nanotubes (CNT) and multi‐layered graphene sheets (MLG) in both their pristine and oxidized forms are discussed. Further, the effect of two different nanofiller concentrations (0.1 and 0.3 wt%) were also studied to optimize the performance. Flexural testing of these composites was performed at room temperature (RT), 70 and 110°C in‐situ temperatures to understand their temperature dependence behavior. From all considered composites, GE composite with 0.1 wt% of oxidized CNT and MLG mixture (O‐(CNT‐MLG)) (1:1) showed best flexural performance at all the in‐situ temperatures. The presence of oxidized CNTs and MLGs in the GE composite provided a synergetic strengthening effect like CNT pull‐outs and crack bridging confirmed through SEM imaging. Besides, oxidation helped in the dispersion of CNT and MLG in the composite. Glass transition temperature (Tg) of all the considered composites was evaluated using Differential Scanning Calorimetry (DSC). Fourier Transformed Infra‐red Spectroscopy (FTIR) was also conducted to confirm the functionalization of CNT and MLG after oxidation. During the fractography study, these composites showed variation in fiber/matrix interfacial bonding, matrix deformation, dispersion of nanofillers and fiber imprints, which helped to understand different failure modes responsible for the gross failure of the composites.
Evaluation ofbisphenol‐Aepoxy cured with diethylenetriamine by using phosphorus containing liquid poly(1,2‐butadiene) as multifunctional additives
Authors: Xiaojing Lv , Wang Jinwei , Guo Yong
Published: October 2022

Phosphorus containing liquid epoxidate polybutadiene (P‐LEPB) is synthesized and used as the additive to improve the flame retardancy and toughness of epoxy resin (EP). The structure of P‐LEPB is confirmed by Fourier transform infrared (FTIR),1H and13C nuclear magnetic resonance (NMR). With the addition of P‐LEPB, EP composites show earlier degradation; and P‐LEPB plays flame retardancy functions as reflected by the increase of limiting oxygen index (LOI) and its promotion of carbonization as seen from the char scanning electron microscopy images after LOI tests. The addition of P‐LEPB improves the water proof performance of EP composites, playing positive effect on resisting water spreading on the surface and immersing in the EP composites as supported by the water absorption rates and contact angle measurements. The elongation at break increases with addition of P‐LEPB and reaches nearly three times higher than the neat epoxy at P‐LEPB addition of 10%, the toughening effect of P‐LEPB is attributed to the diverting function by the P‐LEPB microspheres upon stress loading, which is related to the size and distribution of P‐LEPB additions as seen from their cross‐sectional images of the composites.
Variations in age structure and growth in congeners Lacerta viridis and Lacerta media
Authors: Altunışık Abdullah , Yıldız Mehmet Zülfü , Akman Bahadır , İğci Naşit , Karış Mert , Sömer Mehtap
Published: October 2022

Determining the age of any species allows it to be analyzed from the ontogenetic, demographic, and ecological perspectives. In the present study, we tested the hypothesis that the age structure of congener species (Lacerta media and Lacerta viridis) with the same ecological niche may vary in different areas. In this context, we applied skeletochronology method to reveal various demographic parameters, such as age structure, longevity, age at sexual maturity, growth rate, survival rate, adult life expectancy, and the relationship between age and body size in the green lizard, L. viridis, and the medium lizard, L. media. In L. media and L. viridis, the maximum lifespan was 10 and 8 years, respectively. The mean age and body size of females were significantly greater than those of males in L. media. However, in the examined L. viridis population, no appreciable variation in mean age or body size was found to exist between the sexes. It was estimated that the green lizards reach maturity at the age of 2 or 3 years. However, the L. media reached sexual maturity approximately 1 year later than the congener. The body size markedly increased with age in males for both studied populations. However, in females, body size positively increased with age only in L. media. The approach of skeletochronology that we utilized in this study to assess age structure makes it simple to gather a variety of time‐dependent ecological data for such ectothermic species.
Spätzle1 is a constituent of the extracellular signaling pathway that promotes nodule formation, a cell‐mediated immune response, in caterpillar hemolymph
Authors: Tang Shuyi , Tezuka Moeko , Otsuka Hinata , Sato Ryoichi
Published: October 2022

The existence of an extracellular signaling pathway that mediates nodule formation, a cell‐mediated immune response, has been reported in Bombyx mori larvae. In this pathway, C‐type lectins and the hemolymph serine proteinase BmHP‐8 function in pathogen associated molecular pattern (PAMPs) recognition and signaling transduction. However, which molecule elicits the cellular response at the end of the pathway is unknown. In this study, the Toll ligand Bombyx mori Spätzel1 was shown to be involved in the pathway by applying anit‐Spätzel1 antiserum in an in vitro nodule‐like aggregate formation assay and an in vivo nodule formation assay.
Star anise from a fifteenth century Indonesian shipwreck
Authors: Castillo Cristina Cobo , Fahy Brian , Fuller Dorian Q.
Published: October 2022

Maritime trade routes in Southeast Asia date to at least the last millennium BC evidenced by excavations of port‐cities, entrepôts and early coastal polities in Peninsular Thailand, the Mekong Delta and Island Southeast Asia. This trade network intensified over the next millennium and by the fifteenth century, the number of trade goods throughout Medieval Southeast Asia was prolific. The bulk of studied material comprises trade ceramics, particularly in archaeological investigations of shipwreck cargoes which provide information on regional trading patterns. Although ceramic assemblages constitute the bulk of shipwreck cargo, other types of material have also been found, including the spice star anise. In this paper, we focus on the organic contents from two jars found in the Bakau shipwreck dating to the early fifteenth century AD. The finds are significant as this spice (star anise, Illicium verum) is being transported together with items of high value for trade.
Robust sliding‐mode observer‐based multiple‐fault diagnosis scheme
Authors: Gao Sheng , Ma Guangfu , Guo Yanning
Published: October 2022

In this study, we simultaneously evaluate the multiple‐fault diagnosis problem of a class of Lipschitz nonlinear systems with actuator and sensor faults and unknown input disturbances. A nonsingular system transformation is used to transform the original system into two subsystems for multiple‐fault diagnosis: subsystems 1 and 2. At the system level, two robust sliding‐mode observers (RSMOs) are proposed. An RSMO is designed for subsystem 1 to detect actuator faults subjected to unknown input disturbances, and another RSMO is designed for subsystem 2 to detect sensor faults subjected to actuator faults. At the component level, a bank of RSMOs is proposed to detect and isolate actuators (sensors) with faults using a dedicated observer scheme. The reachability of RSMOs is comprehensively investigated in the estimation error space. Accordingly, the proposed observer parameters are designed as an optimization problem and solved using the linear matrix inequality (LMI) optimization technique. The effectiveness of the proposed multiple‐fault diagnosis scheme was validated through simulations of a modified seventh‐order aircraft system.
Anti‐rheumatoid arthritis effects of Xanthii Fructus by affecting the PI3K‐AKT signaling pathway based on TMT‐labeled quantitative proteomics
Authors: Jiang Hai , Zhang Jiaxu , Yu Huan , Hou Ajiao , Wang Song , Wang Xuejiao , Zheng Senwang , Yang Liu , Kuang Haixue
Published: October 2022

Rheumatoid arthritis is a systemic autoimmune disease characterized by chronic symmetrical multiple arthritis. Current traditional counter‐therapies are expensive and have side effects. Xanthii Fructus has effects in expelling wind and cold, draining the nasal orifice, and removing wind and dampness. However, its mechanism of action against rheumatoid arthritis is unknown. In this paper, the mechanism of the anti‐ rheumatoid arthritis effect of Xanthii Fructus is studied by proteomics. The experimental results show that it could significantly reduce serum inflammatory factor levels, alleviate joint edema, improve vasodilation and congestion, and significantly reduce the number of inflammatory cells. Proteomics results show that the PI3K‐AKT signaling pathway is the key pathway for Xanthii Fructus to treat rheumatoid arthritis. In this study, we obtained a new understanding of the mechanism of Xanthii Fructus in the treatment of rheumatoid arthritis, which provided a theoretical basis for its prevention and treatment and laid the foundation for further research.
Corporate climate reporting of European banks: Are these institutions compliant with climate issues?
Authors: Friedrich Tim Jan , Velte Patrick , Wulf Inge
Published: October 2022

This article focuses on climate disclosures from STOXX Europe 600 banks during the 2017–2020 period, comprising 152 company years. Specifically, we analyze compliance based on general and bank‐specific recommendations of the Task Force on Climate‐related Financial Disclosures. Although our results indicate an overall increase in climate reporting quality over time, we identify major reporting gaps, such as consideration of forward‐looking information (particularly related to scenario analyses). We also stress that the bank‐specific recommendations are taken into account rather insufficiently. This study stands to benefit mostly researchers, business practices, and regulatory bodies owing to the future standardization of European and global sustainability reporting frameworks.
Secondary malignancies and survival of FCR‐treated patients with chronic lymphocytic leukemia in Central Europe
Authors: Kósa Fruzsina , Nečasová Tereza , Špaček Martin , Giannopoulos Krzysztof , Hus Iwona , Jurková Tereza , Koriťáková Eva , Chrápavá Marika , Nováčková Martina , Katinová Ivana , Krejčí Denisa , Jujka Adam , Mátrai Zoltán , Vályi‐Nagy István , Robak Tadeusz , Doubek Michael
Published: October 2022

This is the first large‐scale cross‐country analysis of patients with chronic lymphocytic leukemia (CLL) aimed to evaluate the incidence, types, and key prognostic factors of secondary malignancies, and to assess the impact on overall survival based on retrospective claims data from three Central European countries. We analyzed 25,814 newly diagnosed CLL patients from Czechia, Hungary, and Poland; 10,312 (39.9%) patients were treated for CLL in study periods between 2004 and 2016. Out of the treated patients, 1986 (19.3%) received the FCR therapy in the first line and 779 (7.6%) received FCR in subsequent lines. We observed that 33.7% of treated patients developed secondary malignancies during the study. Based on country estimates, the probability to develop a secondary malignancy within 4 years since starting the first‐line FCR therapy ranged between 28.0% and 36.8%. We found the age at diagnosis, male gender, any malignancy prior to the CLL diagnosis, and the CLL treatment to be the key risk factors for developing secondary malignancies. Specifically, the FCR therapy was a statistically significant (p < 0.001) prognostic factor for risk increase with the hazard ratio between 1.46 and 1.60. Across the three Central European countries, we observed consistent results indicating FCR increased the risk of secondary malignancies in CLL patients. We conclude that secondary malignancies are clearly an undervalued burden for CLL patients, caregivers, and the healthcare system. When evaluating new therapies in regulatory and reimbursement decision making, the factor of secondary malignancies deserves deeper considerations.
Use of multikinase inhibitors/lenvatinib concomitant with radioiodine for the treatment of radioiodine refractory differentiated thyroid cancer
Authors: Herranz Urbano Anido
Published: October 2022

Thyroid cancer is the most frequent endocrine tumor. However, in locally advanced or metastatic disease we have only two types of treatment at our disposal: radioactive iodine (RAI) when the disease is RAI‐sensitive and multikinase inhibitors (MKIs), lenvatinib and sorafenib, when the disease becomes RAI‐refractory (RR). This review revisits the published data on the potential combination of MKIs/lenvatinib with RAI in RR‐differentiated thyroid cancer and evaluates some special situations where this combination may be of particular interest. The combination of MKIs/lenvatinib with RAI could, at least hypothetically, improve the efficacy seen in both treatments alone via a synergistic effect and with a lower rate of toxicity rates. Early preclinical data support this notion, while its generalized use awaits the results of ongoing clinical trials.
Multi‐omics analysis of the oncogenic value of copper Metabolism‐Related protein COMMD2 in human cancers
Authors: Tai Panpan , Wang Zhanwang , Chen Xinyu , Chen Aiyan , Gong Lian , Cheng Yaxin , Cao Ke
Published: October 2022

Background

The copper metabolism MURR1 domain (COMMD) protein family is involved in tumorigenicity of malignant tumors. However, as the member of COMMD, the role of COMMD2 in human tumors remains unknown.

Methods

We used The Cancer Genome Atlas (TCGA), Genotype Tissue Expression (GTEx), Human Protein Atlas (HPA) database, Cancer Cell Line Encyclopedia (CCLE) platform, univariate Cox regression analysis, Kaplan–Meier curve, cBioPortal, UALCAN database, Sangerbox online platform, GSCA database gene set enrichment analysis (GSEA), and GeneMANIA to analyze the expression of COMMD2, its prognostic values, genomic alteration patterns, and the correlation with tumor stemness, tumor mutational burden (TMB), microsatellite instability (MSI), and immune infiltrates, drug sensitivity, and gene function enrichment in pan‐cancer. qRT‐PCR, CCK‐8, EdU, wound healing, and transwell migration assays were performed to confirm the function of COMMD2.

Results

COMMD2 was strongly expressed in most cancer types. Elevated COMMD2 expression affects the prognosis, clinicopathological stage, and molecular or immune subtypes of various tumors. Moreover, promoter hypomethylation and mutations in the COMMD2 gene may be associated with its high expression and poor survival. Additionally, we discovered that COMMD2 expression was linked to tumor stemness, TMB, MSI, immune cell infiltration, immune‐checkpoint inhibitors, and drug sensitivity in pan‐cancer. Furthermore, the COMMD2 gene co‐expression network is constructed with GSEA analysis, displaying significant interaction of COMMD2 with E2F targets, G2‐M checkpoint, and mitotic spindle in bladder cancer (BLCA). Finally, RNA interference data showed suppression of COMMD2 prevented proliferation and migration of BLCA and uterine corpus endometrial carcinoma (UCEC) cells.

Conclusion

Our findings shed light on the COMMD2 functions in human cancers and demonstrate that it is a promising prognostic biomarker and therapeutic target in pan‐cancer.
Clinical models to predict lymph nodes metastasis and distant metastasis in newly diagnosed early esophageal cancer patients: A population‐based study
Authors: Chen Hong , Wu Junxian , Guo Wanting , Yang Lihang , Lu Linbin , Lin Yihong , Wang Xuewen , Zhang Yan , Chen Xi
Published: October 2022

Background

Patients with early esophageal cancer (EC) receive individualized therapy based on their lymph node metastasis (LNM) and distant metastasis (DM) status; however, deficiencies in current clinical staging techniques and the issue of cost‐effectiveness mean LNM and DM often go undetected preoperatively. We aimed to develop three clinical models to predict the likelihood of LNM, DM, and prognosis in patients with early EC.

Method

The Surveillance, Epidemiology, and End Results database was queried for T1 EC patients from 2004 to 2015. Multivariable logistic regression and Cox proportional hazards models were used to recognize the risk factors of LNM and DM, predict overall survival (OS), and develop relevant nomograms. Receiver operating characteristic (ROC)/concordance index and calibration curves were used to evaluate the discrimination and accuracy of the three nomograms. Decision curve analyses (DCAs), clinical impact curves, and subgroups based on model scores were used to determine clinical practicability.

Results

The area under the curve of the LNM and DM nomograms were 0.668 and 0.807, respectively. The corresponding C‐index of OS nomogram was 0.752. Calibration curves and DCA showed an effective predictive accuracy and clinical applicability. In patients with T1N0M0 EC, surgery alone (p < 0.01) proved a survival advantage. Chemotherapy and radiotherapy indicated a better prognosis in the subgroup analysis for T1 EC patients with LNM or DM.

Conclusions

We created three nomograms to predict the likelihood of LNM, DM, and OS probability in patients with early EC using a generalizable dataset. These useful visual tools could help clinical physicians deliver appropriate perioperative care.
New trend to hire NIL general managers brings benefits, risks
Authors: Forer Max , Mayne Nic
Published: October 2022

After only a little more than a year into the name, image, and likeness era of college sports, student‐athletes have gone from not being permitted to receive any compensation for their NIL to giant brands, like Meta and adidas, writing checks and providing NIL education services to student‐athletes at colleges across the country.
Learn to lead across generations
Authors: McCarthy Claudine
Published: October 2022

LAS VEGAS — To lead effectively, coaches and staff need to learn to lead in different ways that are tailored to fit each of the five generations represented on today's college campuses, according to Dr. Tim Elmore, millennial expert and the Founder and CEO of Growing Leaders, who spoke at the annual convention for the National Association of Collegiate Directors of Athletics.
Implement strategies for successfully navigating compliance responsibilities
Authors: McCarthy Claudine
Published: October 2022

LAS VEGAS — There's so much to keep up with in the arena of athletics compliance, and the work often comes with high expectations, requires quick responses, and easily spills over into after‐work hours. But many compliance professionals have little to no staff assistance and are expected to manage multiple areas of the athletics department on top of their already heavy workload.
Did court dismiss gross negligence claim?
Authors: Lyerly Eric
Published: October 2022

A Seton Hall women's basketball player sustained a serious knee injury during practice. The student‐athlete sought medical treatment and received an MRI. She also obtained physical therapy. The MRI showed a bone bruise.
Inhibition of nonstructural protein 15 of SARS‐CoV‐2 by golden spice: A computational insight
Authors: Singh Rahul , Bhardwaj Vijay K. , Purohit Rituraj
Published: October 2022

The quick widespread of the coronavirus and speedy upsurge in the tally of cases demand the fast development of effective drugs. The uridine‐directed endoribonuclease activity of nonstructural protein 15 (Nsp15) of the coronavirus is responsible for the invasion of the host immune system. Therefore, developing potential inhibitors against Nsp15 is a promising strategy. In this concern, the in silico approach can play a significant role, as it is fast and cost‐effective in comparison to the trial and error approaches of experimental investigations. In this study, six turmeric derivatives (curcuminoids) were chosen for in silico analysis. The molecular interactions, pharmacokinetics, and drug‐likeness of all the curcuminoids were measured. Further, the stability of Nsp15‐curcuminoids complexes was appraised by employing molecular dynamics (MD) simulations and MM‐PBSA approaches. All the molecules were affirmed to have strong interactions and pharmacokinetic profile. The MD simulations data stated that the Nsp15‐curcuminoids complexes were stable during simulations. All the curcuminoids showed stable and high binding affinity, and these curcuminoids could be admitted as potential modulators for Nsp15 inhibition.
Best practices in college governance
Authors: Kater Susan T. , Cloud Robert C. , Fossey Richard
Published: October 2022

This chapter provides an overview of the important work of community college trustees and includes best practices as well as the contrasting challenges of rogue trustees and activist boards. Whether a board is made up of trustees who are elected, appointed, or a combination of the two, there are things that colleges should, and could do which would enhance effective governance. Several best practices are presented to inform college leaders and boards of trustees.
Community college governance and trustees as advocates for fiscal support
Authors: White Carol Cutler
Published: October 2022

Community college boards of trustees are not highly visible, but they play a vital role in college and student success through governance and oversight of the mission of open access higher education. The stakes are high as community colleges compete for scarce resources in state budgets making the local and state‐level trustee/governing role as fierce advocates of utmost importance. This chapter describes the different roles and functions of community college trustees across the states with a particular focus on college finance. The article begins by describing community college governance arrangements and duties of state level boards followed by a description of duties for locally governed colleges. The chapter then moves to a discussion of state and local budgetary support of community colleges. The chapter closes with a discussion of political power and implications for trustees to expand budgetary support for community colleges through advocacy.
Successful treatment with cyclosporine and guselkumab for pityriasis rubra pilaris
Authors: Nishimura Mai , Kondo Makoto , Habe Koji , Hayashi Akinobu , Yamanaka Keiichi
Published: October 2022

A man with pityriasis rubra pilaris (PRP) showed no improvement in skin symptoms despite treatment with several drugs. The patient was diagnosed as having type 1 PRP. Combination therapy with cyclosporine and guselkumab improved his skin condition. Here, we propose a novel therapeutic strategy for intractable PRP.
Extensive keloid scarring in a patient with pemphigus vulgaris
Authors: Elinkichari Dorsaf , Zaouak Anissa , Chamli Amal , Hammami Houda , Fenniche Samy
Published: October 2022

Since pemphigus blisters are intraepidermal, scarring should induce at most a post‐inflammatory hyperpigmentation. We describe a very atypical and unusual course of pemphigus vulgaris with extensive keloid formation despite high systemic steroids. This could be promoted by the severe flare of the disease, the delay of scarring, and the superinfection.
Photocatalytic Reduction of CO2by Highly Efficient Homogeneous FeIICatalyst based on 2,6‐Bis(1’,2’,3’‐triazolyl‐methyl)pyridine. Comparison with Analogues.
Authors: Gracia Lisa‐Lou , Barani Elham , Braun Jonas , Carter Anthony B. , Fuhr Olaf , Powell Annie K. , Fink Karin , Bizzarri Claudia
Published: October 2022

Fully earth‐abundant and highly efficient systems for producing syngas CO/H2through photocatalytic reduction from CO2are essential to approach a sustainable way of closing the carbon cycle. Herein, the synthesis and characterization of a new iron complex, FeIIL(NCS)2py, coordinated to an N,N,N‐pincer ligand 2,6‐bis(4’‐phenyl‐1’,2’,3’‐triazol‐1’‐yl‐methyl)pyridine (L), two isothiocyanate groups (NCS) and one pyridine is reported. Its catalytic activity in the photo‐driven reduction of carbon dioxide has been investigated and compared with its CoIIanalogue (CoL(NCS)2py) and their homoleptic complexes ML2. In this work, the catalysts are used in combination with the heteroleptic complex [CuI(dmp)(DPEphos)], where dmp is 2,9‐dimethyl‐1,10‐phenanthroline and DPEPhos is bis[(2‐diphenylphosphino)phenyl] ether, to reach entirely earth‐abundant systems. The new iron heteroleptic complex FeIIL(NCS)2py showed considerable activity with a TONCOof 576 obtained after 4 h (TOF=144 h−1) through visible light (λ=420 nm) and a quantum yield of 7.1 %.
Atomic Dual‐Site Ni/Co‐Decorated Carbon Nanofiber Paper for Efficient O2 Electrocatalysis and Flexible Zn‐Air Battery
Authors: Liu Nianxi , Kumar Anuj , Li Zongge , Liu Zhicheng , Zhao Changkai , Meng Xiangshe , Wang Yaqun , Yang Lei , Zhang Guoxin
Published: October 2022

The fabrication of flexible catalytic films with isolated single/dual‐atomic sites and their integration in wearable electronics is challenging. Herein, an efficient method to prepare atomically dispersed binary Ni/Co‐decorated flexible carbon nanofiber (NiCo‐CNF) film using formamide‐derived cyano‐specific NiCo‐NC as nanofillers was developed. The optimized Ni1Co1‐CNF catalytic film, having large‐area, high density of adjacent Ni‐N4 and Co‐N4 active sites, and good mechanical properties under repeated bending and release conditions, possessed high catalytic activity towards oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). The ORR/OER potential difference (ΔE10) for Ni1Co1‐CNF at 10.0 mA cm−2 was highly comparable with the Pt/C+RuO2 mixture. In addition, flexible Ni1Co1‐CNF‐assembled Zn‐air battery displayed very good mechanical robustness and cycling stability. Our work may inspire the fabrication of other atomic metal‐decorated films for membrane electrocatalysis.
Light Modulated Reversible “On‐Off” Transformation of Arylazoheteroarene Based Discotics in Nematic Organization
Authors: Kumar Pravesh , Bala Indu , De Ritobrata , Kumar Pal Santanu , Venkataramani Sugumar
Published: October 2022

Three benzene‐1,3,5‐tricarboxamide (BTA) core‐based molecular systems appended with phenylazo‐3,5‐dimethylisoxazole photoswitches at the peripheral position through variable‐length alkoxy chains have been designed and synthesized. The supramolecular interactions of the mesogens provided discotic nematic liquid crystalline assembly as confirmed by polarized optical microscopy (POM) and X‐ray diffraction (XRD) studies. Spectroscopic studies confirmed the reversible photoswitching and excellent thermal stability of the photoswitched states in solution phase and thin film. Also, atomic force microscopic (AFM) and POM investigations demonstrated the morphological changes in the self‐assembly induced by the photoirradiation as monitored by the changes in the height profiles and optical appearance of the textures, respectively. Remarkably, the liquid crystalline discotic molecules showed reversible “on and off states” controlled by light at ambient temperature.
Solvent Effects on Ultrafast Charge Transfer Population: Insights from the Quantum Dynamics of Guanine‐Cytosine in Chloroform
Authors: Green James A. , Gómez Sandra , Worth Graham , Santoro Fabrizio , Improta Roberto
Published: October 2022

Invited for the cover of this issue is the group of G. A. Worth, F. Santoro and R. Improta at UCL, ICOOM‐CNR and IBB‐CNR. The image depicts charge transfer from guanine to cytosine in solvent after the absorption of light. Read the full text of the article at 10.1002/chem.202201731.
Chemikalien aus klimaschädlichem CO2
Authors: Richter Michael
Published: October 2022

Aus Kohlenstoffdioxid wichtige Ausgangsmaterialien für Feinchemikalien machen – das funktioniert tatsächlich: Einem Forscherteam des Fraunhofer IGB ist es im Max‐Planck‐Kooperationsprojekt eBioCO2n erstmals gelungen, CO2 in einer auf dem Transfer von Elektronen basierenden Enzymkaskade zu fixieren und in einen festen Ausgangsstoff für die chemische Industrie umzuwandeln. Das Verfahren zur elektrobiokatalytischen CO2‐Fixierung wurde bereits publiziert und gilt als Hot Paper.
Recyclingtechnologien für Kunststoffabfälle
Authors: Krause Lars
Published: October 2022

Einsparpotenziale lassen sich entlang des gesamten Herstellungsprozesses durch den Einsatz von Digitalisierungstechnologien identifizieren und umsetzen. Ziele können eine bessere Prozessstabilität oder vorausschauende Wartung sein.
Grünes Kerosin
Authors: Schär Dirk
Published: October 2022

Gefördert durch Wirtschaft und Politik arbeiten sieben deutsche und südafrikanische Partner nun gemeinsam an der Weiterentwicklung von Fischer‐Tropsch‐Katalysatoren für die effiziente und nachhaltige Produktion von grünen Flugzeugtreibstoffen. Das Projekt Care‐O‐Sene (Catalyst Research for Sustainable Kerosene) ist auf drei Jahre angelegt und hat die massentaugliche Kommerzialisierung grüner Kerosinprodukte ab 2025 zum Ziel.
Wertvoller Informationsaustausch für Betriebsingenieure und die Branche
Authors: Poppe Christian
Published: October 2022

Grußwort zum 25‐jährigen Jubiläum CITplus
PROTOCOL: Are tools that assess risk of violent radicalization fit for purpose? A systematic review
Authors: Hassan Ghayda , Brouillette‐Alarie Sébastien , Ousman Sarah , Madriaza Pablo , Varela Wynnpaul , Danis Emmanuel , Kilinc Deniz , Pickup David , Borokhovski Eugene ,   CPN‐PREV team
Published: October 2022

This is the protocol for a Campbell systematic review. The main objective of this project is to gather, critically appraise, and synthesize evidence about the appropriateness and utility of tools used to assess the risk of violent radicalization.
Septin and actin contributions to endothelial cell–cell junctions and monolayer integrity
Authors: Kim Joanna , Mooren Olivia L. , Onken Michael D. , Cooper John A.
Published: October 2022

Septins in endothelial cells (ECs) have important roles supporting the integrity of the endothelial monolayer. Cell–cell junctions in EC monolayers are highly dynamic, with continuous retractions and protrusions. Depletion of septins in ECs leads to disruption of cell–cell junctions, which are composed of VE‐cadherin and other junctional proteins. In EC monolayers, septins are concentrated at the plasma membrane at sites of cell–cell contact, in curved‐ and scallop‐shaped patterns. These membrane‐associated septin accumulations are located in regions of positive membrane curvature, and those regions are often associated with and immediately adjacent to actin‐rich protrusions with negative membrane curvature. EC septins associate directly with plasma membrane lipids, based on findings with site‐specific mutations of septins in ECs, which is consistent with biochemical and cell biological studies in other systems. Loss of septins leads to disruption of the EC monolayer, and gaps form between cells. The number and breadth of cell–cell contacts and junctions decreases, and the number and frequency of retractions, ruffles, and protrusions at cell edges also decreases. In addition, loss of septins leads to decreased amounts of F‐actin at the cortical membrane, along with increased amounts of F‐actin in stress fibers of the cytoplasm. Endothelial monolayer disruption from loss of septins is also associated with decreased transendothelial electric resistance (TEER) and increased levels of transendothelial migration (TEM) by immune and cancer cells, owing to the gaps in the monolayer. A current working model is that assembly of septin filaments at regions of positive membrane curvature contributes to a mechanical footing or base for actin‐based protrusive forces generated at adjoining regions of the membrane. Specific molecular interactions between the septin and actin components of the cytoskeleton may also be important contributors. Regulators of actin assembly may promote and support the assembly of septin filaments at the membrane, as part of a molecular feedback loop between the assembly of septin and actin filaments.
Pharmacokinetics of Single and Multiple Oral Administration of a Self‐emulsifying Formulation of Highly Purified Eicosapentaenoic Acid Ethyl Ester (MND‐2119) Compared With the Nonself‐emulsifying Formulation in Healthy Male Subjects
Authors: Mori Takuya , Murasaki Kagari , Yokoyama Yuichi
Published: October 2022

MND‐2119 is a self‐emulsifying formulation of highly purified eicosapentaenoic acid ethyl ester (EPA‐E) designed to be administered once daily due to improved absorption compared with the nonself‐emulsifying formulation. In these studies, MND‐2119 was administered to healthy adult males in single or multiple doses. In the single administration study, MND‐2119 (0.5–4 g) was administered under fed and fasted conditions to evaluate MND‐2119 pharmacokinetics and safety under these conditions. This study showed that Cmax and AUC0‐72h of plasma EPA concentration after single administration were higher under fed conditions than under fasted conditions, for all doses. In the multiple administration study, subjects received either MND‐2119 (0.5–4 g) immediately after breakfast or EPA‐E (0.9 g) immediately after breakfast and dinner for 11 days to compare pharmacokinetics and safety of MND‐2119 to EPA‐E. In this study, the rate of rise in Cmin of the plasma EPA concentration with MND‐2119 decreased from days 6 to 8 after administration and was thought to have reached a steady state on day 11. The mean Css,max of MND‐2119 administered as 1 g once daily, and the mean Css,min and the mean AUCss,0‐24h of MND‐2119 administered as 2 g once daily were higher than those of EPA‐E administered as 0.9 g twice daily. No safety‐related issues occurred in either study. These results suggest that MND‐2119 administered once daily may achieve equivalent or higher plasma EPA concentrations compared to the nonself‐emulsifying formulation administered twice daily.
E−Z Isomerization in Guanidine: Second‐order Saddle Dynamics, Non‐statisticality, and Time‐frequency Analysis
Authors: Rashmi Richa , Yadav Pankaj Kumar , Seal Aniruddha , Paranjothy Manikandan , Lourderaj Upakarasamy
Published: October 2022

Our recent work on the E−Z isomerization reaction of guanidine using ab initio chemical dynamics simulations [Rashmi et al., Regul. Chaotic Dyn. 2021, 26, 119] emphasized the role of second‐order saddle (SOS) in the isomerization reaction; however, we could not unequivocally establish the non‐statistical nature of the dynamics followed in the reaction. In the present study, we performed thousands of on‐the‐fly trajectories using forces computed at the MNDO level to investigate the influence of second‐order saddle in the E−Z isomerization reaction of guanidine and the role of intramolecular vibrational energy redistribution (IVR) on the reaction dynamics. The simulations reveal that while majority of the trajectories follow the traditional transition state pathways, 15 % of the trajectories follow the SOS path. The dynamics was found to be highly non‐statistical with the survival probabilities of the reactants showing large deviations from those obtained within the RRKM assumptions. In addition, a detailed analysis of the dynamics using time‐dependent frequencies and the frequency ratio spaces reveal the existence of multiple resonance junctions that indicate the existence of regular dynamics and long‐lived quasi‐periodic trajectories in the phase space associated with non‐RRKM behavior.
Genome Reporting for Healthy Populations—Pipeline for Genomic Screening from the GENCOV COVID‐19 Study
Authors: Frangione Erika , Chung Monica , Casalino Selina , MacDonald Georgia , Chowdhary Sunakshi , Mighton Chloe , Faghfoury Hanna , Bombard Yvonne , Strug Lisa , Pugh Trevor , Simpson Jared , Hao Limin , Lebo Matthew , Lane William J. , Taher Jennifer , Lerner‐Ellis Jordan ,   GENCOV Study Workgroup
Published: October 2022

Genome sequencing holds the promise for great public health benefits. It is currently being used in the context of rare disease diagnosis and novel gene identification, but also has the potential to identify genetic disease risk factors in healthy individuals. Genome sequencing technologies are currently being used to identify genetic factors that may influence variability in symptom severity and immune response among patients infected by SARS‐CoV‐2. The GENCOV study aims to look at the relationship between genetic, serological, and biochemical factors and variability of SARS‐CoV‐2 symptom severity, and to evaluate the utility of returning genome screening results to study participants. Study participants select which results they wish to receive with a decision aid. Medically actionable information for diagnosis, disease risk estimation, disease prevention, and patient management are provided in a comprehensive genome report. Using a combination of bioinformatics software and custom tools, this article describes a pipeline for the analysis and reporting of genetic results to individuals with COVID‐19, including HLA genotyping, large‐scale continental ancestry estimation, and pharmacogenomic analysis to determine metabolizer status and drug response. In addition, this pipeline includes reporting of medically actionable conditions from comprehensive gene panels for Cardiology, Neurology, Metabolism, Hereditary Cancer, and Hereditary Kidney, and carrier screening for reproductive planning. Incorporated into the genome report are polygenic risk scores for six diseases—coronary artery disease; atrial fibrillation; type‐2 diabetes; and breast, prostate, and colon cancer—as well as blood group genotyping analysis for ABO and Rh blood types and genotyping for other antigens of clinical relevance. The genome report summarizes the findings of these analyses in a way that extensively communicates clinically relevant results to patients and their physicians. © 2022 Wiley Periodicals LLC.

Basic Protocol 1: HLA genotyping and disease association

Basic Protocol 2: Large‐scale continental ancestry estimation

Basic Protocol 3: Dosage recommendations for pharmacogenomic gene variants associated with drug response

Support Protocol: System setup