bluuebunny/crossref_metadata_2025 huggingface dataset:
PLURALITAS HUKUM KEWARISAN DI INDONESIA : SEBUAH TINJAUAN NORMATIF
Authors: Rahmatillah Nor Annisa
Published: January 2025

The purpose of this study is to look at the plurality of inheritance laws in Indonesia from a normative point of view. This research analyzes legislation, legal theory, and inheritance practices in customary law, Islamic law, and positive law. Indonesia is a country with a diverse population in terms of religion and ethics, and has a plural legal system, especially in terms of inheritance. This research uses a normative approach to study the legal provisions governing inheritance. These provisions are found in the Civil Code (KUHPerdata), Islamic law through the Compilation of Islamic Law (KHI), and customs that apply in various regions in Indonesia. This research shows that inheritance law is increasingly visible in its diversity, because in fact the customary inheritance law that applies is not only one, but various following the form of society and the family system of Indonesian society. So that the inheritance law applied to all Indonesian people is still different considering the classifications of citizens. Until now, there is no national inheritance law that can regulate inheritance nationally, so that people in Indonesia can choose between the three inheritance laws.
Analisa Nilai Investasi Penjualan Rumah Tipe 36 Pada Perumahan PT. Rahayu Charani Rosend
Authors: Larasati Diah Ayufitria , Respati Rida
Published: January 2025

Increasing demand for affordable housing presents investment opportunities, but requires further research to understand the ability of lower-middle-class communities to afford such housing. The property business is identified as a crucial investment, especially with growing populations and increasingly scarce and expensive land over time. This indicates that the demand for new homes will continue to rise, especially in developing countries and large cities. Critical investment analysis was conducted to provide information to PT. Rahayu Charani Rosend regarding potential profits and risks. This research utilized the Net Present Value (NPV), Profitability Index (IP), Payback Period (PP), and Break Even Point (BEP) methods. Data used included selling prices, housing price lists, and bank interest rates for the year 2023. The research results show an NPV of Rp13,146,894 > 0, an IP value of 4.806 > 1, a PP of 1 month 61 days, and a BEP at 11 units (BEP in Indonesian rupiah equivalent to Rp1,883,601,297). Based on these calculations, it can be concluded that this investment is viable because NPV > 0 and IP > 1.
Model Pemilihan Kendaraan Umum Dan Kendaraan Pribadi Untuk Perjalanan Bekerja Di Kota Palangka Raya
Authors: Widjaya Christian Dwi Putra
Published: January 2025

Low utility of public transport has reduced a lot of public transport passenger numbers and increased use of private modes travel for work, so public transport should be solution has turned into a burden for transportation systems increase the traffic volume due to urban. This study aims to produce models to predict the behavior mode choice valid and reliable, for design the operating model of a competitive public transport and climate policies support the existence of public transportation. To find a way for public transport back to the main mode transportation that are reliable and have a major high utility as well as to suppress the use of motorcycles and private cars. The main model has used was polynomial discrete choice mode by developing a single answer choices at Palangka Raya. The Results has received 2 different logit models. Based on logit models of type I, to up the uses public transport, can be done by pressing the ownership of private vehicles by restricting ownership 1 motorcycle and 1 car. The calculation of logit model II, increasing the use of public transport, can be done by speeding up public transport travel time and adjust travel times using private modes.
Kebocoran Data KPU Penyebab dan Upaya Pencegahan
Authors: Rizki Muhamad , Surgana Surgana
Published: January 2025

Kebocoran data pemilih Komisi Pemilihan Umum (KPU) pada tanggal 27 November 2023 merupakan peristiwa yang sangat mengkhawatirkan dengan potensi dampak negatif pada masyarakat, termasuk penyalahgunaan data pemilih untuk kepentingan politik, kriminal, atau bahkan terorisme. Paper ini mengidentifikasi faktor-faktor utama yang menyebabkan kebocoran data KPU, antara lain kompleksitas sistem informasi, kerentanan perangkat lunak, dan masalah kesadaran pengguna. Kompleksitas sistem informasi data pemilih KPU, yang terintegrasi dengan berbagai sistem lain, membuatnya rentan terhadap ancaman siber seperti malware, phishing, dan serangan denial-of-service. Untuk mengurangi risiko ini, audit keamanan secara teratur oleh ahli keamanan informasi independen sangat diperlukan. Selain itu, penanganan kerentanan perangkat lunak memerlukan pembaruan perangkat lunak secara tepat waktu untuk memperbaiki kelemahan keamanan yang teridentifikasi. Ketidakadaran kesadaran pengguna, khususnya di kalangan petugas KPU, menjadi faktor kritis lainnya. Meningkatkan kesadaran pengguna melalui pelatihan komprehensif tentang prinsip keamanan informasi, jenis serangan siber, dan praktik penggunaan sistem yang aman sangat penting. untuk mencegah kebocoran data di masa depan, pendekatan holistik melibatkan audit keamanan teratur, pembaruan perangkat lunak, dan program kesadaran pengguna yang kuat diperlukan untuk menjaga integritas sistem informasi pemilu.
The modern use of hydroxyurea for children with sickle cell anemia
Authors: Quinn Charles T. , Ware Russell E.
Published: January 2025

Over the past 40 years, the introduction and refinement of hydroxyurea therapy has led to remarkable progress for the care of individuals with sickle cell anemia (SCA). From initial small proof-of-principle studies to multi-center Phase 3 controlled clinical trials and then numerous open-label studies, the consistent benefits of once-daily oral hydroxyurea have been demonstrated across the lifespan. Elevated fetal hemoglobin (HbF) serves as the most important treatment response, as HbF delays sickle hemoglobin polymerization and reduces erythrocyte sickling. Increased amounts of HbF, especially when distributed across the majority of erythrocytes, improve clinical outcomes by reducing hemolytic anemia and preventing vasoocclusion, thereby ameliorating both acute and chronic—and overt and covert—complications. Additional benefits of hydroxyurea beyond HbF induction include lower neutrophil and platelet counts, reduced inflammation, and improved rheology. Toxicities of hydroxyurea in SCA are typically mild and predictable; modest cytopenia is expected and actually therapeutic, while occasional gastrointestinal and cutaneous manifestations are well-tolerated. Long-term risks of hydroxyurea for SCA are mainly theoretical but require ongoing surveillance. Accordingly, hydroxyurea should be initiated as part of standard-of-care, ideally in the first year of life. Proper dosing of hydroxyurea is critical, aiming through stepwise dose escalation to achieve modest but safe myelosuppression, with periodic adjustments for weight gain. Precision dosing using pharmacokinetics may facilitate optimal dosing without frequent dose adjustments. Although transformative and even curative therapies for SCA are emerging, hydroxyurea is the only available and accessible disease-modifying treatment that can address the global burden of disease, especially in low-resource settings within sub-Saharan Africa.
Recipient sex and donor leukemic cell characteristics determine leukemogenesis in patient-derived models
Authors: Stanger Anna MP. , Arnone Marlon , Hanns Pauline , Kimmich Lucca M. , Kübler Jessica , Gekeler Sarah , Görsch Elsa S. , Kramer Lea , Baer Marcelle , Schroeder Jan C. , Mills Taylor S. , Konantz Martina , Rudat Saskia S. , Lengerke Claudia
Published: January 2025

In acute myeloid leukemia (AML), leukemogenesis depends on cell-intrinsic genetic aberrations and thus, studies on AML require investigations in an in vivo setting as provided by patient derived xenografts (PDX) models. Here we report that, next to leukemic cell characteristics, recipient sex highly influences the outgrowth of AML cells in PDX models, with females being much better repopulated than males in primary as well as secondary transplantation assays. Testosterone may be the more important player since, strikingly, better engraftment was seen in castrated versus control male recipients, while ovariectomy did not significantly impair engraftment in females. Shorter time-to-engraftment and mouse survival were observed with adverse molecular risk, and respectively with high FLT3-ITD ratio mutated AML cells. Adverse risk AML furthermore showed higher percentages of phenotypic leukemic stem cells (LSCs), suggesting impaired differentiation capacity in these AML subtypes. Overall, we achieved successful repopulation with 14/23 (61%) favorable, 18/30 (60%) intermediate and 4/8 (50%) adverse risk AML cases in female recipient PDX models. Our data identify recipient sex as an important experimental confounder in leukemia PDX models, and the contribution of the sex hormones to leukemogenesis as an intriguing, underexplored research area.
Relapsed childhood T-cell acute lymphoblastic leukemia and lymphoblastic lymphoma
Authors: Hughes Andrew D. , Pölönen Petri , Teachey David T.
Published: January 2025

While outcomes for pediatric acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) have improved dramatically in recent decades, relapsed and refractory disease remain a significant therapeutic challenge. This is particularly true for patients with T-cell ALL and LBL, where survival for patients with relapsed/refractory disease remains dismal. Recent efforts to comprehensively profile the genomics of T-ALL/LBL to improve understanding of disease biology have enhanced our ability to identify high-risk patients at diagnosis who are more likely to relapse and have also identified novel targets for precision medicines. Novel immunotherapies have transformed the treatment landscape for patients with B-cell ALL (B-ALL). Many immunotherapies are under investigation in clinical trials for patients with T-ALL/LBL and early results are very promising. Given these insights into disease biology and the development of targeted and immune-based treatments, it is reasonable to hope for improved patient outcomes, although challenges still exist. In this review, we summarize the present state of understanding of the risk factors for relapse of T-ALL/LBL, established treatment regimens, and the promising small molecule inhibitors and immunotherapies with the potential to revolutionize the treatment of relapsed/refractory T-ALL/LBL.
We still need to hit hard in acute myeloid leukemia, but only in the right patients
Authors: Ganser Arnold
Published: January 2025

Not available.
Ảnh hưởng của blockchain và trí tuệ nhân tạo đến chất lượng kiểm toán độc lập tại Việt Nam
Authors: Lại Thị Thu Thủy , Trần Bình Minh
Published: January 2025

Nghiên cứu này phân tích tác động của công nghệ blockchain và trí tuệ nhân tạo đến chất lượng kiểm toán tại các công ty kiểm toán độc lập ở Việt Nam. Dữ liệu từ 247 giám đốc kiểm toán và trợ lý kiểm toán được thu thập và mô hình SEM đã được sử dụng để đánh giá mối quan hệ giữa các biến số. Kết quả cho thấy cả blockchain và trí tuệ nhân tạo đều cải thiện hiệu quả và chất lượng kiểm toán, trong đó trí tuệ nhân tạo đặc biệt hiệu quả trong phát hiện gian lận và đánh giá rủi ro. Nghiên cứu khẳng định rằng việc ứng dụng blockchain và trí tuệ nhân tạo không chỉ tăng cường tính minh bạch và độ tin cậy của các báo cáo tài chính, mà còn giúp hiện đại hóa quy trình kiểm toán, mang lại lợi ích thiết thực cho các công ty kiểm toán, nhà đầu tư và cơ quan quản lý.
Pembuatan Website Inventory Urban Material: Pendekatan PHP & MYSQL
Authors: Nova Sindy
Published: January 2025

Inventori merujuk pada persediaan barang yang dimiliki oleh perusahaan, mencakup bahan baku, barang dalam proses, dan barang jadi. Persediaan ini disimpan untuk berbagai tujuan strategis, seperti memenuhi kebutuhan pelanggan dan menjaga kelancaran operasional produksi. Sistem pengelolaan inventori memegang peranan penting dalam memastikan pengawasan dan pengelolaan stok barang dapat dilakukan secara efektif. Pengembangan situs web dilakukan menggunakan metode Software Development Life Cycle (SDLC) dengan model Waterfall. Hasil dari penelitian ini adalah sebuah sistem berbasis web yang memungkinkan pengguna untuk melakukan penambahan, pengubahan, dan penghapusan data inventori, serta menyediakan laporan stok secara otomatis. Uji coba terhadap sistem menggunakan metode black box testing menunjukkan bahwa seluruh fungsi situs web bekerja sesuai dengan yang diharapkan. Implementasi sistem inventori berbasis web ini diharapkan dapat memberikan solusi bagi Toko Urban Material dalam mengurangi kesalahan pencatatan stok dan mempercepat pengambilan keputusan yang berkaitan dengan manajemen persediaan.
Transpormasi Bisnis Di Era Digital: Peluang, Tantangan, Dan Strategi Inovasi
Authors: Asrul Asrul
Published: January 2025

Transformasi digital telah menjadi fenomena yang mengubah lanskap bisnis global secara signifikan. Penelitian ini bertujuan untuk menganalisis peluang, tantangan, dan strategi inovasi yang diperlukan bagi perusahaan dalam menghadapi perubahan yang dipicu oleh kemajuan teknologi digital. Pendekatan penelitian ini menggunakan metode kualitatif dengan analisis studi kasus pada perusahaan yang berhasil dan gagal beradaptasi dengan transformasi digital. Hasil penelitian menunjukkan bahwa digitalisasi menciptakan berbagai peluang, seperti efisiensi operasional, akses pasar global, dan pengalaman pelanggan yang lebih baik. Namun, tantangan signifikan juga diidentifikasi, termasuk ancaman keamanan siber, perubahan perilaku konsumen, dan kebutuhan untuk pengembangan keterampilan digital di kalangan karyawan. Strategi inovasi yang efektif melibatkan penerapan teknologi terkini, penguatan budaya organisasi yang adaptif, serta kolaborasi dengan mitra bisnis dan startup teknologi. Kesimpulan dari penelitian ini menegaskan bahwa keberhasilan transformasi bisnis di era digital sangat bergantung pada kemampuan perusahaan untuk berinovasi dan beradaptasi secara dinamis. Rekomendasi praktis disajikan untuk membantu organisasi memanfaatkan peluang digital sambil memitigasi risikonya.
Business Strategy Analysis of Kopi Kenangan Using Porter's Five Forces
Authors: Warja Ade Agung Gunawan , Abdurahman Abdurahman , Purnamasari Pupung
Published: January 2025

This research analyzes the business strategy of Kopi Kenangan using Porter’s Five Forces framework to understand the competitive dynamics in Indonesia’s grab-and-go coffee industry. Utilizing a desk research approach, secondary data from various sources were processed and qualitatively analyzed. The results show that Kopi Kenangan has leveraged brand differentiation, product diversification, and investment support to strengthen its market position. However, threats from new entrants, supplier power, and intense competition remain significant challenges. This study provides strategic insights for coffee industry players to survive and thrive in a competitive market.
The Effect of Exchange Rate Fluctuations on Egyptian International Business Transactions: An Empirical Analysis
Authors: Abdelraouf Mohamed , Muharram Farid
Published: January 2025

This study examines the impact of exchange rate fluctuations on international business transactions in Egypt from 2005 to 2022. Using pooled and fixed effects models, the research analyses the relationship between exchange rates, inflation, GDP, and export volumes. Key findings include a statistically significant positive relationship between exchange rate fluctuations and international business transactions, with fixed effect models revealing that the exchange rate, inflation rate, and GDP significantly affect export volume at a 99% confidence level. Exchange rates account for a large proportion of export volume changes, with adjusted R-squared values between 0.66 and 0.75. These results underscore the importance of exchange rate stability for international trade in Egypt. The study contributes to the literature by providing empirical evidence from a developing economy context, offering insights for policymakers and businesses on risk management and strategic decision-making in international trade.
Cryoablation Pulmonary Artery Denervation for the Treatment of Combined Post-Capillary Pulmonary Hypertension Caused Be Left Heart Diseases
Authors: B Rudenko , D Feshchenko , F Shukurov , O Tkacheva
Published: January 2025

Introduction: Pulmonary artery denervation is rapidly evolving method for treatment of pulmonary hypertension. The purpose of our first-in-man study is to assess the effectiveness of cryoablation for pulmonary artery denervation in patients with pulmonary hypertension secondary to a left heart disease.

Methods: 24 patients with combined post capillary pulmonary artery hypertension (mPAP ≥25 mm Hg, PCWP >15 mm Hg, PVR >3.0 WU or DPG ≥ 7 mm Hg (or both) were included in the study. The effectiveness of cryodenervation was assessed according to the changes in clinical status, functional capacity and pulmonary hemodynamics during 12-month follow-up.

Results: There were no complications during and immediately following the cryoablation procedure. There was significant increase in functional capacity measured by 6MWT: 319 ± 18 m before cryodenervation and 502 ± 22 m (p<0.05) at 12 months follow-up. The N-terminal pro–brain natriuretic peptide value decreased from 2928 ± 223 ng/mL at baseline to 989 ± 67 ng/mL (p<0.05). The right heart catheterization demonstrated the distinctive reduction of mean pulmonary artery pressure (mPAP) from 59 ± 6 to 32 ± 4 mm Hg, pulmonary vessel resistance (PVR) from 9,3 ± 2,2 to 3,4 ± 1,5 WU and diastolic pulmonary gradient (DPG) from 11 ± 2.1 to 8 ± 0.8 mm Hg (p<0.05). Also the decrease of pulmonary capillary wedge pressure (PCWP) from 23 ± 3.5 to 19 ± 2.3 mm Hg was also observed (p<0.05).

Conclusions: This is the first clinical study to demonstrate the clinical, functional and hemodynamic benefits of cryoablation procedure in patients with combined postcapillary PAH caused by left heart diseases.
Atrial Fibrillation, When and What are the Optimal Blood Pressure Values to Prevent it?
Authors: Paterno Marchioli Carlos Alberto
Published: January 2025

Hypertensive Cardiovascular Disease is a complex, multifactorial, and chronic illness, frequently beginning during childhood or adolescence, could develop functional and/or structural cardiovascular organ damage by the increase of the volume/pressure level and the arterial stiffness, even before it exceeds the “normal” systolic and diastolic blood pressure levels. In the last decades, the pulsatile arterial function has been increasingly recognized as a major determinant of cardiovascular risk. It is known that hypertension is the most prevalent independent risk factor for atrial fibrillation in the population. Both structural remodelling and subsequent electrophysiological changes by atrial fibrosis constitute an arrhythmogenic substrate for the induction and maintenance of atrial fibrillation.

Atrial fibrillation has been associated with stroke, heart failure, and cardiovascular mortality. The research of non-antiarrhythmic drugs is a new and very interesting field of challenges to prevent atrial fibrillation onset and control recurrences.

The study aimed to know if there is some limit of age to make an effective treatment, and which systolic and diastolic values are necessary to achieve to stop atrial fibrillation.
Hypertension Study in Non-Pregnant Women in the Cardiology Department of the University Hospital Gabriel Toure (UH-GT), Bamako (Mali)
Authors: HO Ba , Y Camara , I Sangaré , D Traoré , K Kamaté , T Tchedre , GRC Millogo , F Samassékou , M Konaté , CT Doumbia , A Maiga , RM Dakouo , A Sogodogo , H Camara , B Diarra , M Touré , B Sonfo , A Traoré , M Diakité , M Sako , AK Sacko , S Coulibaly , I Diall , I Menta
Published: January 2025

Introduction: Little data are available on female hypertension in our context, motivating the realization of this study to determine its prevalence and the associated electro- and echocardiographic abnormalities.

Methodology: We conducted a cross-sectional study Results over 6 months in the cardiology department of the CHUGT by including patients aged 18 years and over seen in consultation and in whom the diagnosis of hypertension was made. All patients consented to participate in the study after information on the study and the absence of prejudice in the event of refusal. Data collection was carried out by observing the rules of confidentiality on a form then the data were inserted into an Access database and their analysis carried out by IBM SPSS version 20. The quantitative data are presented as means with standard deviation and the qualitative data as proportions. The level of significance of the tests was set at 5%.

Results: The prevalence of female hypertension was 61.8% of consultations. The means for age and body mass index were 52 ± 14.461 years and 27.35 ± 06.585 kg/m2, respectively. The main electrocardiographic abnormalities were dominated by left ventricular hypertrophy (LVH) and sinus tachycardia in 93.6 and 46.4% of cases, respectively. On the echocardiographic level, LVH, reduced ejection fraction and relative wall thickness were found in 41.05, 37.35 and 21.91%, respectively.

Left ventricular mass and ventricular geometry were abnormal in 44.4 and 37.3% of cases. Remodeling was the most common geometric abnormality with 18.2% and type II mitral flow with 90.2% the most common relaxation abnormality.

Conclusion: Female hypertension is common with electrical and echocardiographic changes including LVH and new younger patients, hence the need for an intensification of preventive measures, particularly life style and dietary measures, which do not require large financial resources.
Bridging the Gap in Pediatric Care: Occupational Therapy and Joint Compressions in Primary Care Practice
Authors: Shanholtz Cathy Felmlee , Gamber Michelle
Published: January 2025

This case report highlights the role of occupational therapy (OT) in addressing developmental delays within primary care, particularly in rural areas where access to specialists is limited. Madison, a three-month-old infant, presented with motor delays but faced long wait times for specialist appointments. OT intervention, involving joint compressions to enhance proprioception and motor function, was introduced early through a family connection, resulting in significant improvement. This case underscores the potential of OT to bridge gaps in care, reduce delays, and provide cost-effective, timely interventions, advocating for OT integration in primary care settings to enhance pediatric healthcare outcomes.
Patient Outcomes after Surgical Repair of Acromioclavicular Joint Using Cerclage-Wire Figure of ‘8’ Technique at Kumi Orthopaedic Center; A Retrospective Consecutive Case Series
Authors: Ekure John , Amuron Naomi , Kilama Douglas , Buluma Phillip , Iloket Andrew , Joel Ediomu , Peter Ojelel , Akello Faith
Published: January 2025

Introduction: Proposed surgical methods for the repair of Acromio-clavicular Joint (ACJ) vary widely. However, the currently available treatment modalities require high technology e.g. specialised sutures that impose a high financial burden to patients especially in low and middle income countries. A modified technique using cerclage wire figure of ‘8’ technique was innovated by the lead surgeon at Kumi-orthopaedic Center for the management of ACJ disruptions that would be suitable for use in low resource settings. However, there was no study done to assess the patient outcomes and quality of life hence this study.

Methods: This study was a retrospective consecutive case series of 7 patients that had been managed for ACJ disruptions at KOC using the cerclage wire figure of ‘8’ technique. The outcomes were assessed using the participants’ shoulder constant score, radiological findings and the quality of life measured using the DASH and EQ-5D-5L scores following the surgical repair.

Results: Of the 8 participants, the mean age was 37.8 years (SD±4.9). Majority of the participants were male 5 (62.5%) and the commonest mechanism of injury was Road Traffic Accidents (RTA) 6 (75.0%). The right hand was the dominant hand amongst all the participants with the right and left shoulders being affected equally. The median time to surgery following injury was 7 days. The mean number of years of follow up were 5.8 years. Only 1 participant reported history of having repeated injury to the affected shoulder after surgery.

The mean shoulder score was 89.3 (SD ± 10.7) with a range of 68.5 to 100, the mean DASH score was 11.7 (SD ± 13.9) with a range of 0 to 41.67 and the mean EQ-5D score was 0.756 (SD ± 0.314) with a range of -0.152 to 1.0. On radiographic evaluation, 6 participants (75.0%) had normal AC joint with 2 (25.0%) still having a widened AC joint. 2 participants had osteoarthritis in the affected shoulder, 2 participants had re-displacement according to the study definition and all had wire breakage with 1 participant having a history of repeated surgery to remove the broken wire.

Conclusion: Cerclage wire figure of 8 technique produces comparable results to other high technology surgical techniques used in the management of ACJ disruptions, especially in terms of the shoulder score. This technique could be recommended for use in low resource settings.
Seeing the Job Interview from the Eyes of Students: The Sensory Professional in Brazil Collaborating with Mind Genomics and Artificial Intelligence
Authors: Augusto Pedro Pio C , Bolini Helena MA , Moskowitz Howard R , Rappaport Stephen D , Mulvey Taylor
Published: January 2025

The paper presents a synthesis of artificial intelligence and Mind Genomics to understand what students should be thinking about when they prepare for a corporate job interview in the field of sensory analysis. The integration of artificial intelligence with actual data from real people shows the power of using artificial intelligence to suggest ideas, of people who evaluate these ideas, of statistics, which uncover patterns, and then for straightforward interpretation and recommendation based upon artificial intelligence coupled with human understanding. The paper is one of the first of its kind to show a practical, simple approach, one that can be done in days at an affordable price for students and other interested parties.
Review of Diamond like Carbon Films Fabrications and Applications as New Biomaterials in Medical Field
Authors: Alanazi Ali
Published: January 2025

Many materials have been developed for biomedical applications, and many researchers still aim to develop biomaterials that have better properties than the currently-used ones do. In order to develop a new biomaterial, there are two basic approaches: one is the development of a pure biomaterial made of a single chemical substance and the other a composite biomaterial made of more than two different substances. The latter approach can be realized, for example, by coating a material with another one. In terms of corrosion and compatibility, this approach seems to have some advantages. For example, 1) a thin coat with anti-corrosion and good compatibility material will convert a corroded substrate, which has a unique and advantageous physical property, into a new anti-corrosion composite material. Therefore, the development of anti-corrosion coating-material can result in numerous new composite, and 2) it is nowadays very difficult to develop a pure material that has anti-corrosion materials. One of the candidate coating-materials is diamond-like carbon (DLC). In this paper, the author reviewed whether DLC has anti-corrosion, and furthermore explored the relationship between the physico-chemical properties and the production parameters of DLC applications in medical field.
Natural Products to Slow Down Obesity
Authors: Ping-Chung LEUNG , Wat Elaine , King Fai CHENG
Published: January 2025

Obesity has become an international health problem. Obesity could be a unique health issue for affluent populations, but its correlations with chronic diseases like diabetes and cardiovascular problems are facing a rising trend.

Treatment for the control of obesity has been confined to different ways of change of life-styles: careful food intake and bodily exercises. For the very severe presentations, gastric operations to facilitate the passage of food intake have been advocated. Likewise, the use of specific medication to artificially reduce the neuro-psychological yearn for food is available. These drastic measures are subject to criticism.

Using natural products like medicinal plants to control obesity could be a favorable choice once proven effective.

In Traditional Chinese Medicine records, many herbal items have been described to be effective against obesity: from simple prescriptions recommended for slim body-build in ancient times, to more sophisticated formulations in modern times against over-weight or more specific presentation like Metabolic Syndrome.

We have gained solid experience on the creation of an evidence-based health drink and another 4 herbs formula against Metabolic Syndrome. Clinical evidences have been gathered through standard platform studies, followed by pilot clinical trials. The two items have been found safe to consume and are indicated for further in-depth studies to up-grade the clinical quality.
Advances in Otorhinolaryngological Community Services: The Hearwho App in Southern Nigeria
Authors: Akpalaba Immaculata Ogechi , Imouokhome Martin Okhawere , Akpalaba Raphael Uchenna Enyinnaya , Ogisi Festus Oritsemajemite
Published: January 2025

Background: Current research recorded hearing loss in 8.5million Nigerians. Hearing loss can be prevented and treated. Most individuals in the communities are unaware. Available hearing screening instruments are not readily accessible in communities. Regular screening is the key. Hence, the introduction of the HearWHO App in the communities, a mobile hearing screener.

Aim: To detect hearing loss and otological disorders. - To validate the HearWHO App in the communities - To launch the HearWHO App in the communities.

Materials and Methods: Commenced after obtaining due ethical clearance, informed consent and permissions. A 3-year duration study (March 2020 to March 2022). Study centres were 4 motor parks in Benin City Edo State (Muyi line, Faith motors, Iyare motors and Magorawa terminal) and 2 hospitals in Ondo City, Ondo state (General Hospital and Trauma Centre of the UNIMEDTH complexes). Ambient noise was recorded. Total population sampling technique was used. Health education was given. Using the HearWHO App in mobile smartphone connected to earpiece, each participant’s ears were tested. Each ear was regarded as a separate entity. Otoscopy was done. Findings of hearWHO App were compared with Otoscopic findings. Data realized were documented and analyzed with SPSS -23. P value < 0.05 was regarded statistically significant.

Results: 175 individuals participated, giving 350 ears examined. There were abnormal HearWHO findings in 77.4% ears compared to abnormal Otological findings in 65.0% ears. Predominant otological disorder was Eustachian Tube Dysfunction. Association of HearWHO finding with location was statistically significant (P=0.014).

Conclusion and Recommendation: Hearing loss and otological disorders were detected. There was agreement between HearWHO normal findings and normal otological findings. Based on challenges encountered, there is need to develop additional Apps or modify the HearWHO App to ensure Sustainable Developmental Goal -3 (SDG -3). Thus, creating a better future today making impact with mobile technology.
Oxytocin versus Oxytocin and Melatonin in Reduction of Blood Loss at Cesarean Section in a Resource Poor Setting, Southeast Nigeria: A Double Blinded Randomized Controlled Trial
Authors: Nwaedu Uchenna Nelson , Umeora Odidika Ugochukwu Joannes , Nwali Matthew Igwe , Adebayo Joshua Adeniyi , Nnonyelu Cosmas Ayadiuno , Mba Upo Emeri , Agboeze Joseph , EGEDE John Okafor , Nweke Nnenna Assumpta
Published: January 2025

Purpose: Oxytocin is used to prevent hemorrhage due to uterine atony but postpartum hemorrhage is still a problem. Melatonin was suggested as an adjunct to oxytocin in blood loss reduction during cesarean. This study determines the effectiveness of Melatonin with oxytocin versus Oxytocin alone in reducing blood loss at cesarean section.

Methods: A double blinded randomized controlled trial for cesarean section. One arm received 10mg of sublingual melatonin while the other arm received placebo (100mg of Vitamin C) after spinal Anesthesia. 10IU of intravenous Oxytocin was given to both arms after the delivery of the baby. The concept of intention to treat was used for protocol deviations during the study period.

Results: Sociodemographic, indication and type of surgery were fairly distributed in the two arms. There was no significant difference in preoperative hemoglobin and platelet count. Blood loss was lower in melatonin arm (P < 0.001) and postoperative hemoglobin (P = 0.003). The placebo arm higher difference between preoperative and postoperative hemoglobin (P < 0.001) and received higher blood transfusion (P = 0.049). Side effects and neonatal outcome were same.

Conclusion: Melatonin with oxytocin reduces blood loss during cesarean section more than oxytocin alone with minimal fetal and maternal side effects and should be encouraged.

Contribution: Combination of sublingual melatonin and oxytocin reduces hemorrhage, blood transfusion and maternal mortality after cesarean section.
Curing “Incurable” Autoimmune Diseases Using Resonance Therapy
Authors: Victor Praznikov
Published: January 2025

It has been established that autoimmune diseases are curable. Thanks to resonance therapy, autoimmune conditions and diseases can be reduced to zero and thereby make a very great contribution to the cure of autoimmune diseases. The healing process itself is not much different from curing diseases associated with the resonance of destruction or the resonance of creation. A healing principle has been identified that is very close to both diseases associated with the resonance of destruction or the resonance of creation. The drug that is manufactured must be potentiated, i.e. its potency increases and this drug is tested at the stages of increasing potency for effective treatment of the disease itself.
The Need for Public Awareness on Health-Related Consequences of Heterosexual Anal Intercourse (HAI) in Sub-Saharan Africa
Authors: Lema VM
Published: January 2025

Human sexual repertoire continues to expand and diversify as a consequence of changing socio-cultural beliefs/ practices, demographics, sexual liberation, and increased access to sexually-oriented materials. Individuals actively seek and experiment on various novel and exotic methods of sexual stimulation and gratification including anal eroticism. Despite associated stigma, negative perceptions and its being a taboo practice in some societies, anal eroticism is widely practiced by women from all social and racial backgrounds.

Heterosexual anal intercourse (HAI), itself a high-risk sexual practice, is often associated with other high-risk sexual or social behaviours such as substance abuse, transactional sex, partner violence/coercion, alcohol consumption, multiple partnerships, oro-anal sex and low condom use. It therefore confers an increased risk of STIs, HIV/AIDS and anal cancer among other health consequences.

Sexual practices in sub-Saharan Africa (SSA) are thought to be limited to penile-vaginal intercourse; with penile- anal intercourse confined to gays, female sex workers and the pornographic industry. This perception, together with related social stigma and national legal frameworks, have hampered quality research and creation of awareness on the subject. People engage in HAI oblivious of related health risks. Likewise health professionals, either deliberately or for lack of knowledge, don’t broach the subject in their clinical sessions or other professional forums.

SSA has the highest burdens of HIV/AIDS and STIs globally with weak health systems. Published data on HAI, though few and limited to special population sub-groups, indicate the possibility of the practice among general populations and is increasing. Thus a concern that these health conditions will increase with time, exerting enormous strains on national economies and reversing gains made so far. To mitigate the impact of individual sexual practices on overall health of populations, there is need for appropriate local research, public awareness and health professional education on various aspects of heterosexual anal intercourse in SSA.
Taking into Care as a Social Educational Measure and a Benchmark for Child Protection in Germany? Negative Consequences for Children, Families, Public Health and the Economy
Authors: RG Holzheimer , D Ballhorn
Published: January 2025

Introduction: The number of children and young people being taken into care and placed in out-of-home care has been increasing in Germany for years - despite or perhaps because of child protection reforms. Child protection is always questioned when cases of child abuse become public. Child protection without taking children into care is hard to imagine. Child protection can be violated through unjustified detention. This usually receives little attention.

Methodology: Examination of the keywords “taking into care”, “out-of-home care”, “effect” and “side effects” of “taking into care” by the “Youth Welfare Office” in “Germany” in Pubmed, Google Scholar, and Google.

Results: The number of people taken into care increased after the change in child protection regulations for the youth welfare office in 2005: from 25,664 in 2009 to 66,400 in 2022. Apart from the unaccompanied entry of children in 2022 (28,600), 22,900 cases were due to excessive demands and relationship problems of the parents, and 18,500 cases were due to neglect, and physical and psychological abuse as the reason for being taken into care. The classification of cases varies greatly depending on the social worker's opinion. There are considerable differences in the assessment of the risk situation and the resulting decision to take someone into care. Depending on the federal state, the number of times taken into care and the duration of out-of-home care vary due to different interpretations of guidelines and the requirements of service instructions. The main problem is the high number of false-positive assessments of threats to children's well-being in connection with the ignorance of the effects and side effects of taking children into
care, which is described as a social-educational measure. Anglo-American studies of children in foster families and homes found these children to have post-traumatic stress disorders, an increased risk of serious illnesses, hindrance to participation in social life with inability to go to school, and limitations in their ability to work. Many illnesses only appear in adulthood. The effects of being taken into care can endanger a young person's existence. Even the Federal Constitutional Court 11/2023 points out the negative effects of being taken into care. This causes material and immaterial damage to children and families and puts a strain on the public health system and the national economy.

Conclusion: Child protection must be oriented towards children and not adults, authorities, and institutions. Taking children into care, without even knowing or taking into account the effects of false-positive risk prognoses, that is described as a social educational measure, that is stigmatizing and associated with the loss of basic rights of children and parents, given the damage to children and families, as well as the burden of the public health system and the national economy, cannot be accepted.
Group Psychotherapy - Concepts and Interpretation Techniques
Authors: da Silva Alina MAPN , Paiva Nogueira da Silva Luiz Carlos Miller , Saldanha Anita LR , Margeotto Ana Paula Pantoja , Gasparoto André Luis Valera , Rocha Martinez Tania Leme da
Published: January 2025

The concept of group interpretation, arising from the opposition to the concept of individual interpretation, necessarily had in its origin a teleological character. Group would be the interpretation that benefits the group and not any of its components, in which case the interpretation would be individual, although done in a group. It is understood that only in theory are there interpretations that deserve, rigorously, the name of individual interpretations in groups. In fact, for an interpretation to reach only one of the components of a group, it would be essential that there is no intercommunication between the affected patient, the beneficiary, and the other components of the group. It has never been possible to observe groups in which such intercommunication did not exist entirely. It seems to us that it always exists in all groups, even those in which integration is minimal. Good integration, it is time to remember, presupposes intercommunication.
In-Home Storage and Disposal of Drugs in Libya
Authors: Sharif Suleiman I , Altarhoni Hajer , Elshareef Hakma , Eljazwey Batol , Elshareef Ayop , Faraj Sara , Algumati Ameera , Shelabi Azziza
Published: January 2025

Background: In-home storage and disposal of drugs is an overlooked health issue that may lead, if in appropriately practiced, to serious health hazards.

Objectives: This study was undertaken to assess the methods of storage of medicines at home, and disposal of unused and expired drugs.

Methods: We used a prepiloted questionnaire posted on the net. The questionnaire includes questions on demographics of participants, whether they have a home pharmacy or cabinet, when and what they check their home pharmacy for, and the methods employed to dispose of expired drugs. Collected data were encoded and analyzed using Statistical Package for the Social Sciences (SPSS, version 20, Chicago, IL, USA). Descriptive statistics was used to describe the study variables using frequencies and percentages.

Results: A total of 350 completely filled questionnaires were received back. Age of the majority (305, 87.7%) of the participants ranged between 18-44 years, and most (87.1%) of them were females, and have high school education (81.1%), and have home pharmacy, kept in the kitchen (49.4%) or bedroom (30.3%). About 60% of the participants assigned organization of the home pharmacy to son/ daughter. The average number of drugs stored at home is 14.3. About 50% they check the home pharmacy monthly (319, 91.1%) for expired medicines, and disposed of expired medicines by throwing in domestic waste.

Conclusion: It is necessary to increase public’s awareness of proper methods of storage of drugs at home, and also the appropriate methods of disposal of expired drugs. Health authorities and pharmacists should collaborate to produce guides and a system of return-back leftover, unused, and also municipalities in every city can arrange for appropriate gross disposal of such drugs under the supervision of health authorities.
Respon Tanaman Kangkung Air (Ipomoea aquatica) terhadap Pemberian Pupuk Organik Cair Dengan Metode Hidroponik Sterofoam (Rakit Apung)
Authors: Ummah Shobihah rifatul , Laili Saimul , Tito Sama' Iradat
Published: January 2025

Kangkung is one of the vegetables favoured by the community. Two types of water spinach are often found, namely land kale and water spinach. Kangkung contains nutrients, several vitamins, and various irons that are useful for health and body growth. Hydroponic farming is an agriculture that does not use soil media and uses water as the preferred medium. This study aimed to determine the response of water spinach plants (Ipomoea aquatica) to the application of liquid organic fertilizer with Styrofoam hydroponic media and to determine the effective concentration that affects the growth of water spinach plants. Using the method of Experimental Randomized Block Design. Each nutrient had five treatments and five replications, with treatment concentrations of 5 ml/litre, 10 ml/litre, 15 ml/litre and 20 ml/litre. The results showed that the most influential treatment on plant height, number of leaves, root length, number of roots, wet weight and dry weight was in the P1A4 treatment (AB-mix 20ml/litre), while the high eco-farming treatment was in the P2A3 treatment. (eco-farming 15 ml/litre). In the control treatment, there was no significant effect on the treatment of eco-farming and the growth of water spinach plants.
Keywords: water spinach, AB-mix, eco-farming, water spinach growth
Kangkung adalah salah satunya sayuran yang digemari oleh masyarakat. Jenis kangkung yang sering ditemui ada dua yaitu kangkung darat dan kangkung air. Kangkung memiliki kandungan gizi serta beberapa vitamin dan berbagai zat besi yang berguna bagi kesehatan dan pertumbuhan badan. Pertanian sistem hidroponik adalah suatu pertanian yang tidak menggunakan media tanah dan memakai media air yang diutamakan. Tujuan dari penelitian ini yaitu untuk mengetahui respon tanaman kangkung air (Ipomoea aquatica) terhadap pemberian pupuk organik cair dengan media hidroponik sterofoam dan untuk mengetahui konsentrasi efektif yang berpengaruh terhadap pertumbuhan tanaman kangkung air Penelitian dilakukan di kebun yang terletak di Jalan Joyo Suryo Lowokwaru Malang, selama bulan Juli sampai agustus 2021. Menggunakan metode Eksperimental Rancangan Acak Kelompok (RAK). Pada masing-masing nutrisi terdapat 5 perlakuan dan 5 kali ulangan, dengan konsentrasi perlakuan 5 ml/liter, 10 ml/liter, 15 ml/liter dan 20 ml/liter. Hasil penelitian menunjukkan bahwa perlakuan paling berpengaruh tinggi terhadap tinggi tanaman, jumlah daun, panjang akar, jumlah akar, berat basah dan berat kering yaitu pada perlakuan P1A4 (AB-mix 20ml/liter), sedangkan pada perlakuan eco farming yang tinggi yaitu pada perlakuan P2A3 (eco farming 15ml/liter). Pada perlakuan kontrol tidak berpengaruh nyata pada perlakuan eco farming serta pertumbuhan tanaman kangkung air. 
Kata kunci : kangkung air, AB-Mix, eco-farming, pertumbuhan kangkung air