bluuebunny/crossref_metadata_2025 huggingface dataset:
Menumbuhkan Sikap Disiplin Anak Melalui Standar Operasional Prosedur di Sekolah Islamic Preschool
Authors: Siregar Lea Sartika
Published: July 2023

Artikel yang ditulis ini memiliki tujuan supaya mengetahui bagaimana penyelenggaraan standar operasional prosedur di sekolah Safaraz Islamic Preschool dan apakah melalui standar operasional prosedur ini mampu menumbuhkan sikap disiplin anak usia dini. Dalam kegiatan observasi ini peneliti menggunakan metode kualitatif dengan teknik wawancara, observasi dan dokumentasi. Dari pembahasan, peneliti menemukan hasil bahwasanya sikap disiplin anak akan tumbuh ketika diterapkan sebuah metode pembiasaan sejak anak usia dini. Metode pembiasaan ini bisa disebut sebagai standar operasional prosedur (SOP) yang mana pada standar ini anak diajarkan suatu kebiasaan yang terus menerus diulang sehingga mendapatkan hasil tumbuhnya sikap disiplin yang akan melekat dalam diri anak sampai ia dewasa. Maka dari itu, melalui hasil penelitian yang di dapatkan peneliti semoga bermanfaat bagi pembaca untuk menambah wawasan. Lalu, diharapkan dapat bermanfaat bagi guru sebagai acuan dalam mengembangkan karakter disiplin anak melalui penerapan standar operasional prosedur (SOP) di lembaga pendidikan. Untuk kepala sekolah, diharapkan dengan hasil penelitian ini juga bisa dijadikan sebagai salah satu upaya untuk lebih mengembangkan standar operasional prosedur (SOP) agar lebih baik jika diterapkan dalam pendidikan anak usia dini. Terakhir, untuk para peneliti lain yang juga ingin meneliti lebih dalam lagi terkait standar operasional prosedur penulis berharap tulisan ini bermanfaat dan juga sebagai salah satu ilmu baru untuk menambah wawasan tentang penyusunan, pengimplementasian dan pengembangan standar operasional prosedur (SOP).
Eksperimen Permainan Memancing Ikan Warna Terhadap Kemampuan Mengenal Warna Pada Anak Usia 4-5 Tahun
Authors: Puspita Galuh Dhyah , Khotimah Nurul
Published: July 2023

Children aged 4-5 years, kindergarten education is an option to help the child's growth and development process. One of the developments of children aged 4-5 years that needs attention is the development of their sense of sight. Through color recognition, the sensitivity of his sense of sight is honed. In addition, color recognition is an early anticipation of the occurrence of color blindness in children. This study aims to determine the influence of color fish in fishing game as one of the process to improve the cognitive ability of children aged 4-5 years in recognizing colors. The type of research used is quantitative research through the One Group Pre-Test Post-Test Design method. The data collection techniques used are observation and assessment the final result. Observation results from the pre-test and post-test were then calculated using the Wilcoxon Signed Rank test. The result of this study that there is an influence on color fish fishing game on the ability to recognize colors in children aged 4-5 years in Dharma Wanita Persatuan Lampah Kindergarten. Through the Wilcoxon test, it is known that the signification value is 0.000 < 0.05. The post-test showed that 89% of children were in the starting to develop (MB) category and 11% were developing as expected (BSH). Meanwhile, the post-test results show that 100% of children increased into the very well developed category (BSB). Thus, it can be concluded that the color fish of fishing game can be used to improve the ability to recognize colors in children aged 4-5 years in Dharma Wanita Persatuan Lampah Kindergarten, Gresik.
Gerakan Literasi Pada Anak Usia Dini Melalui Outdoor Learning Activity
Authors: Sumini Ni Komang , Andari Ida Ayu Made Yuni
Published: July 2023

The implementation of the literacy movement through outdoor learning activities is done in an integrated manner, meaning that these activities can be carried out in the subjects, not fixated on Indonesian literacy or English literacy. Children can recognise letters and numbers while playing outside the classroom, creating an exciting and fun atmosphere. The literacy movement aims to develop students' character and aims to instil a culture of literacy in students to create lifelong learning. The literacy movement has several specific objectives, namely; Firstly, promoting a culture of literacy. Secondly, increasing the capacity of educated citizens and the school environment, and thirdly, making schools a fun and child-friendly learning park for school children to manage knowledge. Finally, the continuity of learning by presenting a variety of textbooks that suit different reading strategies. This study uses a descriptive qualitative approach to the process of implementing GELIS through outdoor learning activities in early childhood at Hooray School Denpasar.
Pengembangan Media Gatuko Berbasis Aplikasi Android Untuk Mengenalkan Sikap Tanggung Jawab Pada Anak Usia Dini
Authors: Astuti Meriana Wahyu , Ningrum Mallevi Agustin
Published: July 2023

Developing and teaching responsible behavior from an early age is very important, which is adjusted to the limits of children's abilities. The method used is the Research and Development method. The ADDIE Model (Analyze, Design, Development, Implementation, and Evaluation). Limited trial subjects were kindergarten children aged 5-6 years with a total of 14 children. Data collection techniques used assessment instrument sheets. The data analysis technique used in this study uses Wilcoxon match pairs. The results of the assessment of the experts obtained a score of 95% from the material expert, from the media expert obtained a value of 93.75% while from the trial the teacher obtained a score of 100% and 95.8%. Based on the effectiveness results, the significance value (2-tailed) is 0.001 so that p <0.05 or 0.001 <0.05, because the result of the significance value is less than 0.05 then Ho is rejected and Ha is accepted, which means there is an average difference -the average between pretest and posttest which experienced an increase in score so that it can be concluded that the use of Gatuko media based on the Android application is effectively used to introduce an attitude of responsibility to obey the rules at school in children aged 5-6 years.
Personal Branding KPH. Purbodiningrat Sebagai Anggota Dewan Perwakilan Rakyat Daerah Istimewa Yogyakarta
Authors: Sarasati Anggita , Dida Susanne , Nugraha Aat Ruchiat
Published: July 2023

Popularity does not guarantee that others will know the individual. One of the politicians is KPH Purbodiningrat, who was only considered to have taken advantage of the popularity and title he had as the advantage that he had as a mantu ndalem of the Yogyakarta Palace when he was a member of the DPRD-DIY. The purpose of this research is to discover the identity that KPH Purbodiningrat wants to show, the efforts made in building and maintaining personal branding, and the performance and achievements obtained while being a member of the DPRD-DIY. This research uses a post-positivistic paradigm with a qualitative approach and case study research type. The data obtained in this study were through observation, interviews, online data searches, and literature study. The result from this research is identity shown by KPH Purbodiningrat is that it still holds the cultural value of the privilege of Yogyakarta. It looks conservative because it keeps cultural values. However, this conservative's values can only be seen from his values ​​and ideology till he keeps. In carrying out activities and other activities, KPH Purbodiningrat can adapt to the environment and the times. His activities are cut up into online and offline, and the performance and achievements obtained by KPH Purbodiningrat are not only in the realm of members of the DPRD-DIY but also outside the role of members of the DPRD-DIY. The conclusion of this study conclude that the identity shown by KPH Purbodiningrat is as a member of the DPRD-DIY who has adaptive conservative. The advice given from the results of research in strengthening personal branding can emphasize the value of communicating messages by using jargon, as well as by utilizing social media. The consistency of messages must be the highlight and monitoring and evaluation of content and news in social media.
Exploring the Impact of Emerging New Media and Communication Technologies on Society: A Scoping Review
Authors: Boediman Eko Putra
Published: July 2023

Tinjauan ruang lingkup ini mengeksplorasi dampak dari media baru dan teknologi komunikasi yang sedang berkembang pada masyarakat, dengan fokus pada efek teknologi pada komunikasi, budaya, dan interaksi sosial. Penelitian ini bertujuan untuk memberikan gambaran umum tentang penelitian terbaru, menganalisis potensi manfaat dan kekurangan teknologi baru seperti media sosial, perangkat seluler, dan platform digital lainnya. Penelitian ini menggunakan metodologi tinjauan cakupan, yang melibatkan pencarian sistematis dan analisis literatur yang ada tentang topik tersebut. Penelitian ini mengkaji beberapa aspek dari media baru dan teknologi komunikasi, termasuk dampaknya terhadap komunikasi interpersonal, wacana politik, dan gerakan sosial. Temuannya menunjukkan bahwa media baru dan teknologi komunikasi memiliki implikasi yang signifikan bagi masyarakat, membentuk cara orang berinteraksi dan terlibat dalam wacana publik. Meskipun teknologi ini telah menciptakan peluang baru untuk komunikasi dan kolaborasi, teknologi ini juga menghadirkan tantangan baru, seperti penyebaran informasi yang salah dan pengikisan privasi. Tinjauan cakupan ini berkontribusi pada pemahaman yang lebih dalam tentang dampak teknologi baru terhadap masyarakat, menyoroti perlunya penelitian berkelanjutan dan pengembangan kebijakan dan praktik yang mempromosikan penggunaan yang bertanggung jawab dan mengurangi potensi bahaya. Temuan ini penting bagi para akademisi, praktisi, dan pembuat kebijakan.
Pembelajaran Komunikasi Politik Menyambut Pemilihan Umum Serentak di Indonesia
Authors: Andari Ida Ayu Made Yuni , Wiguna Ida Bagus Alit Arta
Published: July 2023

Political communications include forms of communication that occur in the political environment, including communications in elections, political campaigns, policy making, political decision making, and interactions between government and society. This research aims to analyse how democratic communication ahead of the general election, to study the communication of political elites and parties, the communication of parties participating in the 2024 general election with the community, the involvement of religious leaders in political communication, internal party and inter-party communication. In this research, the author uses a qualitative research method with a content analysis approach. Data processing in this research is done by critical analysis, comparison, and interpretation of various search results from primary and secondary sources. The results of this research are 1) A deep understanding of the target audience that is relevant and attractive to voters 2).  Utilisation of social media and digital technology 3). Transparency and trust are key in building a good relationship between political parties, candidates, and voters 4). Accurate and objective voter education about the electoral process 5). Collaboration with voters 6). Responsiveness to emerging issues is important in maintaining relevance and speed in delivering political messages. 7). Evaluation of the communication strategy used.
Penanaman Nilai-Nilai Karakter Berbasis Storytelling Cerita Keagamaan
Authors: Sutama I Wayan
Published: July 2023

Religious stories that developed in the archipelago, especially the Mahabharata story, became a guide for the people in the life of the nation and state. Education as a means of educating the nation through the mastery of knowledge must be followed by character education so that it can become a whole human being. Religious stories contain various noble values that can strengthen character. This paper aims to understand and analyze the form of character education values contained in Wanaparwa as a form of community adaptability in various conditions faced. This research uses a descriptive qualitative approach with hermenuetic studies. Using literature studies, the results show that the dominant character values found in Wanaparwa stories are truth or honesty, religion, hard work and perseverance. Six value orientations in the Wanaparwa story fulfill Spranger's theory of theoretical value, economic value, aesthetic value, social value, political value, and religious value fulfill the interpretation of the meaning of the Wanaparwa story. Wanaparwa stories are worthy of being adopted by educators (communicators) as media (messages) containing noble character values to be conveyed to students (communicants) through the storytelling method (channel) to strengthen character (effect).
Angiogenesis In Oral Squamous Cell Carcinoma
Authors: Hande Alka
Published: July 2023

Introducon : OSCC shows a high suscepbility for invasive growth and cervical lymph node metastasis. Prolonged exposure to carcinogens may lead to the unregulaon of tumor suppressor genes and oncogenes, epigenec and cytogenec alteraons, and mutaons in mitochondria. Angiogenesis is crical for tumor progression, as tumor cell growth frequently outstrips the supply of O and nutrients. Demonstraon of angiogenesis in tumor stroma can be 2 carried out by IHC using anbodies CD105. Thus, the present study aims at assessing the expression of CD105 in oral squamous cell carcinoma. Material and Methods : The study comprised of 60 histopathologically diagnosed and surgically operated cases of OSCC of various histopathological grades from the departmental archives. The paraffin embedded ssue secon of 4μm was obtained from archival ssues of OSCC (Group 1) and normal oral mucosa (Group 2) which were stained for roune Hematoxylin and Eosin and for the expression of CD 105 by immunohistochemistry for the determinaon of micro vessel density. Observaons & Results: We observed significantly increased MVD in poorly differenated OSCC in comparison to moderately differenated OSCC and well differenated OSCC. However, when comparison was made between the well and moderately differenated OSCC, the difference was stascally nonsignificant. Conclusion : There was an increased MVD, in poorly differenated OSCC, which could be used as an addional criterion to histologically grade the tumor.
Future of Engineered Phage Therapy for Clostridium difficile Infections
Authors: Nubgan Amer Saeed
Published: July 2023

Bacteriophages have the potential to eliminate both antibiotic-resistant and sensitive bacteria; as a result, they have become a major focus of such research. In contrast to antibiotics, which assault the entire bacterial population without discrimination, bacteriophages have a limited set of characteristics that allow them to target infectious microbes while avoiding friendly species (commensal microbiota). Nevertheless, large groups of naturally occurring bacteriophages that are well-differentiated and selective for the most clinically recognized pathogenic bacterial strains are required. Utilizing genetic engineering techniques that modify the target phage genome to synthesize phages with known characteristics in a brief period of time and at a low acquisition, characterization, and treatment cost. Clostridioides difficile is the leading cause of nosocomial acquired diarrhea, causing approximately 500,000 cases of Clostridium difficile infection (CDI) and nearly 29,000 deaths annually in the United States. It is believed that vancomycin contributes to the disruption of the gut microbiota, resulting in decreased colonization resistance against CDI and increased recurrence rates due to the continuous disruption of the gut microbiota. This article provides a concise summary of existing CRISPR-Cas systems that can be utilized to create a lytic phage as a potential treatment for CDIs. While additional research is required, phage treatment shows promise as a targeted and possibly more sustainable method of preventing severe C. difficile infections.
Frullania tamarisci (L.) Dum. - A new phorophyte for Stigonema cf. minutum (C.A.Agardh) Hassall
Authors: Srivastava S. , Alam Afroz
Published: July 2023

Bryophytes along with some Algae and Lichens form the primary components of the terrestrial ecosystem. They are often found in close association and intermingled with each other. A cyanophycean alga, Stigonema cf. minutum (C.A.Agardh) Hassall has been found growing as an epiphyte on Frullania tamarisci. The association is peculiar as the algal filaments form a close net all over the surface of phorophyte. F. tamarisci, a new phorophyte for an epiphytic cyanohycean alga from India is being reported.
Potential of bryophytes in forest establishment
Authors: Saxena Dinesh , Kaur Harinder , Saxena Anuj
Published: July 2023

Several species of bryophytes are pioneers on new ground, thus bryo-cover serves as ideal seed bed by binding the soil and retaining high moisture content. Bryophytes due to lack of cuticle absorb nutrients directly from the atmosphere, whereas antibiotically active substances in them inhibit the growth of pathogenic bacteria and fungi. The present article focuses on the potential of bryophytes in forest establishment.
PERAN PENYULUH AGAMA ISLAM MEMBERIKAN EDUKASI AKHLAK TERHADAP REMAJA DI DESA JONGKONG KIRI TENGAH KECAMATAN JONGKONG
Authors: Asmawati Asmawati , Sri Sunantri Hifza
Published: July 2023

This study focuses on the role of Islamic religious instructors in educating adolescents about association with a qualitative research approach and a type of case study research. The data collection technique that the authors use in this study is to use observation, interview and documentation techniques. Sources of data in this study were obtained from several respondents, namely teenagers, Muslim families with teenage children, Islamic religious counselors, the Office of Religious Affairs (KUA), the community, community leaders and religious leaders. The results of the study show that the role of Islamic religious instructors in providing education in the Jongkong community, especially for adolescents, is by providing teaching, guidance, exemplary, straightening the understanding of Islam. The method used by Islamic religious instructors in providing religious understanding for adolescents in Jongkong Kiri Tengah Village is by means of an individual approach, direct communication, group and indirect communication, while the Islamic religious education material delivered is about aqidah, worship, sharia and morals. While the form of coaching carried out by Islamic religious instructors in Jongkong Kiri Tengah Village includes (1) activating mosque youth activities, (2) activating sports activities.
PENGEMBANGAN EVALUASI DAN ALAT TES DALAM PEMBELAJARAN PAI BERBASIS IT DI MI ASY-SYAFI’IYYAH KOTA SINGKAWANG
Authors: Assadi Assadi , Ubabuddin Ubabuddin
Published: July 2023

Learning Islamic Religious Education (PAI), tests and evaluation tools have an important role in measuring students' understanding of subject matter and their ability to apply religious values ??in everyday life. This research is a qualitative research, with data collection methods through observation, documentation and interviews. Data analysis using triangulation. Based on the use of these tests and evaluation tools, several conclusions can be drawn: 1. Measuring understanding: Tests and evaluation tools are used to measure the extent to which students understand the concepts and principles in PAI. Through tests, teachers can evaluate students' understanding of subject matter and identify areas that need strengthening or improvement. 2. Development of attitudes and values: Apart from understanding concepts, tests and evaluation tools can also be used to measure students' attitudes towards religion and moral values. Tests such as ethical assessments or case studies can help teachers evaluate the extent to which students apply religious values ??in everyday life. 3. Skills development: Tests and evaluation tools can also measure a student's ability to apply practical skills related to Islamic Religious Education, such as reading and understanding religious texts, attending religious services, or participating in religious activities.
Major clinical evidence of the optimization of the use of CO2 fractional ablative laser with cells and molecules: a systematic review
Authors: Liedtke Fernanda Soubhia , Rajapaksa Samadhi Wishwanath
Published: July 2023

Introduction: Ablative fractional CO2 laser skin resurfacing describes the process of removing the superficial epidermal and dermal layers of the skin to reduce the cutaneous signs of photoaging. The clinical efficacy and safety of exosomes, adipose tissue stem cells, platelet-rich plasma, and resveratrol as adjuvant therapy after ablative fractional CO2 laser application are evidenced by the world literature. Objective: It was to carry out a systematic review to list the main clinical outcomes of the use of fractional ablative CO2 laser, with or without associated techniques, for facial aesthetic treatment. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from April to May 2023 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 86 articles were found. A total of 32 articles were fully evaluated and 17 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 10 studies at high risk of bias and 37 studies that did not meet the GRADE. It was concluded that ablative fractional CO2 laser offers a safe and effective treatment for disfiguring facial scars. It was shown that the improvement in the appearance and quality of the scar was significant for the patient, with a significant impact on the patient's quality of life. Based on these findings, we suggest including ablative fractional CO2 laser in the concept of facial scar treatment. The results demonstrate that the ablative fractional CO2 laser of low fluence and low density is a safe and efficient option for the photorejuvenation of the face. Repeated application of ablative fractional CO2 laser to skin with melasma can result in lasting improvement due to its destructive effect on melanocytes. Furthermore, the combined use of exosome gel with CO2 laser resurfacing would provide synergistic effects on both the efficacy and safety of atrophic acne scarring treatments. ADSC-CM with CO2 resurfacing is a good combination therapy for the treatment of atrophic acne scars and skin rejuvenation. The combined use of ablative fractional CO2 laser and PRP obtained better results. Resveratrol can improve photoaging alone and add efficacy to fractional ablative laser treatment and decrease the adverse effects induced by fractional ablative laser.
Major evidence and guidelines for antibiotic therapy in implant dentistry: a systematic review
Authors: Ponce Vera Melannye Sophia , Criollo Jimenez Martha Elizabeth , Idalgo Fabio Alarcon , Pereira Silvio Antonio dos Santos , Nunes Alexandre Gomes , Kassis Elias Naim , Cicareli Alvaro José
Published: July 2023

Introduction: Dentistry was favored by the discovery of osseointegration, which has become important in the treatment of partially and edentulous patients. Initially, osseointegration was used only to treat edentulous patients in the maxilla and mandible, using a single type of implant, prosthetic abutment, and rehabilitation protocol. However, as the applications of osseointegration evolved, complications also increased, which became more numerous and are no longer the result of surgical and mechanical problems of the components of a single care protocol, requiring more research, studies, and care. In this scenario, the use of antibiotics in implantology is very common and the abuse of antibiotics is more and more frequent. The rational use of antibiotics in the oral implantology process needs the support of evidence-based medicine. The prophylactic use of antibiotics in dental implantology was reviewed in the present study, including the summary of different risks of infection, such as peri-implantitis and maxillary sinusitis after lifting the maxillary sinus floor. Objective: To carry out a systematic review of the literature on the real effects of antibiotic therapy on implantology, especially in the pre-procedure phase. The present study was based on studies of guidelines, with emphasis on the German directive. Main findings and conclusion: The current evidence of antibiotic prophylaxis from oral and maxillofacial surgery was summarized by the planned German S3 guideline “antibiotic prophylaxis in surgery”. Perioperative prophylactic antibiotics can reduce SSI in major procedures, such as head and neck cancer surgery, and prophylaxis is only beneficial for 24 hours. In orthognathic surgery, preoperative antibiotics can reduce SSI with good quality evidence, but it benefits prolonged therapy, and which regimen is most effective remains uncertain. In traumatology, perioperative antibiotic prophylaxis for mandibular fractures and Lefort-1/2 can reduce the SSI, but antibiotic regimens should not be prolonged in the postoperative period by 24 hours. For dentoalveolar surgery, the evidence is more ambivalent. For dental implants, perioperative antibiotics as single injection prophylaxis before placement can reduce dental implant failure, but not SSI. For the removal of third molars, antibiotic therapy in the perioperative period is of uncertain benefit for healthy patients, but it was not possible to obtain evidence to evaluate antibiotic therapy for patients with pre-existing conditions.
Early and mid-term outcomes of patients treated with catheter-directed thrombolysis combined with percutaneous rotational mechanical thrombectomy for deep vein thrombosis
Authors: Kocaoglu Alper , Ovali Cengiz
Published: July 2023

Aim: Deep vein thrombosis (DVT) is an important disease that may cause serious morbidity and mortality. In the current study, we aimed to evaluate the employability of the mechanical thrombectomy and combination of it with catheter-directed thrombolysis in selected patients with acute and/or subacute DVT.
Material and Methods: We applied mechanical thrombectomy and catheter-directed thrombolysis in the patients who admitted with an index diagnosis of lower extremity acute and/or subacute DVT. The thrombus in the femoral vein and iliac vein was intervened by intervention from the popliteal vein. Afterwards, mechanical thrombectomy and catheter-directed tPA infusion for 24 hours were applied. In follow-up, patients were evaluated through physical examination and Doppler ultrasonography on the 1st_, 6th_, 12th_, and 18th_month follow up, and scored with Villalta.
Results: The mean age was 59.9 years. Twenty-six and 21 of the 47 patients were male and female, respectively. In the 1st-month follow-up visit, there was ≥50% patency in 43 patients, and ≥90% patency in 30 patients. During the 18-month follow-up period, while three patients had recurrent DVT, one patient had a new DVT episode in the contralateral extremity. According to Villalta score, three patients were found to have post-thrombotic syndrome (PTS) at the end of 18 months.
Conclusion: We think that; pulmonary embolism (PE) and PTS rates would decrease with the concomitant application of percutaneous interventions to medical treatment in patients with index DVT diagnosis. Additionally, although the cost of percutaneous interventions seems to be high, it would be much more cost effective in the long-term when the complications related to DVT are taken into account. We also think that lowering the burden of thrombus in the acute period would preclude development of long-term complications.
Are calcium antagonists necessary to all patients with radial artery during off-pump coronary surgery?
Authors: Sahin Mehmet , Piri Ertan , Tekindur Sukru , Kuralay Erkan
Published: July 2023

We have made distal radial artery pressure measurement and compared it to another preoperatively cannulated radial artery pressure in order to evaluate the necessity of calcium channel blockers during and after off-pump surgery. If there was more than 20 mmHg gradients between two arms we decided to use calcium channel blockers. Significant pressure gradient (>20 mmHg) was detected in only two percent of our patients.
N-acetylcysteine reduces severity and mortality in COVID-19 patients: A systematic review and meta-analysis
Authors: Alam Mohammad , Hasan Mohammad , Maowa Zannatul , Khatun Fahima , Nazir K , Alam Mohammad
Published: July 2023

Objectives: Recent clinical studies suggest that oxidative stress is one of the key players in the pathogenesis of coronavirus disease 2019 (COVID-19), and N-acetylcysteine (NAC), a potent anti¬oxidant, has been shown to improve clinical outcomes in COVID-19 patients. We conducted a systematic review and meta-analysis of the literature published on the therapeutic intervention of NAC on COVID-19 infection.
Methods: We searched PubMed, Google Scholar, and Science Direct. We identified and screened eight studies with 20,503 participants, including 2,852 in the NAC-treated group and 17,651 in the placebo group, which reported the effect of NAC on COVID-19 infection. A meta-analysis was performed using forest plots under fixed effect estimates based on the standardized mean difference (SMD) and risk ratio (RR).
Results: Pooled analysis showed that NAC was associated with lower mortality in patients with COVID-19 compared with the placebo group [RR, 0.65; (95% CI: 0.56 to 0.75); p < 0.0001]. Similarly, C-reactive protein (CRP) [SMD, −0.32; (95% CI: −56 to −0.09); p = 0.0070] and D-dimer [SMD, −0.35, (95% CI: −0.59 to −0.10; p = 0.0062] levels were significantly decreased, and the oxygenation marker, PaO2/FiO2 ratio, was increased in the NAC-treated group compared with the placebo group [SMD, 0.76; (95% CI: 0.48 to 1.03); p < 0.0001].
Conclusion: Although the number of included studies was minimal, this meta-analysis suggests that NAC may have a positive effect on COVID-19 outcomes, specifically, a significant decrease in CRP and D-dimer levels and a significant increase in oxygen saturation, which decreased mortality. We have also presented a comprehensive review of the role and mechanisms of NAC in patients with COVID-19.
Characterization of multidrug-resistant potential pathogens isolated from milk and some dairy products in Egypt
Authors: Ashraf Dina , Ombarak Rabee , Samir Ahmed , Salam Ayah
Published: July 2023

Objective: This study aimed to explore the incidence and antimicrobial resistance (AMR) of Escherichia coli, Staphylococcus aureus, and Bacillus cereus in raw milk and some Egyptian dairy products, namely Kariesh cheese and rice with milk.
Material and Methods: 112 samples (70 raw milk, 30 Kariesh cheese, and 12 rice with milk) were randomly collected from different districts in Cairo and Giza, Egypt. The samples were examined for E. coli, S. aureus, and B. cereus presence. The susceptibility of the obtained isolates was tested against 11 antimicrobials using the disk diffusion method, and further, the presence of AMR genes was examined.
Results: The incidences of E. coli, S. aureus, and B. cereus were 69.64%, 12.5%, and 16.7% in the examined samples, respectively. The antibiogram indicated that E. coli isolates (n = 60) were resistant to gentamycin (73.33%), ampicillin (AM, 53.3%), and cefotaxime (CTX, 16.66%). Multidrug-resistant (MDR) E. coli strains (n = 5) were tested for β-lactams resistance genes. blaTEM was detected in all isolates, and two of them additionally carried blaCTX-M. Staphylococcus aureus isolates (n = 10) were resistant to AM (100%), followed by tetracycline (TE), CTX, and gentamycin (60% each). All MDR S. aureus strains (n = 4) carried blaZ and tetK, and three of them additionally carried aac(6’)-aph (2’’). Bacillus cereus isolates (n = 30) showed resistance to AM (100%), amoxi¬cillin (20%), and TE (6.66%). bla and tetA genes were detected in all MDR B. cereus isolates (n = 6).
Conclusion: Our findings denote the high incidence of potential health hazards in raw milk and some of its products and the existence of AMR bacteria, including MDR strains, which can cause human illnesses that are difficult to treat.
Autophagy characteristics of phytoestrogens in management and prevention of diseases: A narrative review of in-vivo and in-vitro studies
Authors: Khater Safaa , Shalabi Maram , Alammash Buthainah , Alrais Alaa , ahmadi Doaa , Alqahtani Leena , Khamis Tarek , Abdelaziz Sahar , Aldawy Khalifa
Published: July 2023

Phytoestrogens are non-steroid polyphenolic materials present in 300 plants. Regarding their structural similarities to estradiol, phytoestrogens attach to estrogen receptors and display anti-or pro-estrogenic activities. This review explored phytoestrogens’ potential advantages and autophagy properties in light of their future application for disease management, highlighting how phytoestrogens could modulate autophagy. Research has examined the prospective benefits of phytoestrogens for the anticipation and management of various conditions, including signs of menopause, tumors, skin deterioration, osteoporosis, heart disease, neurodegenerative conditions, disorders of the immune system, and metabolic syndrome, owing to their therapeutic effects. As phytoestrogens can activate or inhibit autophagy, which has antioxidant, apoptotic, anti-mutagenic, anticancer, transcriptional, and genomic impacts on cancer and aging illnesses, phytoestrogens could influence diseases through the modulation of autophagy. The collaborative research on animal models, utilization of genetic techniques, and administration of pharmacolog¬ically active substances has indicated the possible therapeutic benefits of autophagy modulation in various illnesses. Further research is required to illustrate the pathways by which phytoestro¬gens modulate autophagy and the possible therapeutic effects on these diseases.
Investigations on some indicators in the blood of cattle with orosthenic activity tongue rolling
Authors: Binev Rumen
Published: July 2023

Objective: Hematological studies were carried out in cattle with tongue-rolling hyperactivity in order to establish the etiopathogenetic mechanisms of this behavioral disorder.
Materials and Methods: Cattle were divided into two groups: Group 1 (n = 12), control animals that did not demonstrate the tongue-rolling orosthenic activity, and Group 2 (n = 12), cattle that manifested this stereotyped behavior. Blood samples were collected from all cattle twice at 10-day intervals from Vena jugularis for analysis of red blood cell counts, hemoglobin (HGB) content, mean corpuscular volume (MCV), mean corpuscular HGB (MCH), mean corpuscular HGB con¬centration (MCHC), hematocrit (HCT), white blood cell counts (WBC), and differential white cell counts [lymphocytes (LYM), monocytes (MON), and granulocytes (GRAs)]. Some blood biochemi¬cal constituents were assayed: calcium, inorganic phosphorus, magnesium, plasma total protein, blood glucose, total bilirubin, urea, creatinine, chlorides, cholesterol, triglycerides, and albumin, as well as the enzyme activities of aspartate amino-transferase (AST), alanine amino-transfer¬ase (ALT), alkaline phosphatase (ALP), gamma-glutamyltransferase (γ-GT), lactate dehydrogenase (LDH), and creatine kinase (CK). Blood concentrations of the hormones adrenaline, noradrenaline, cortisol, adrenocorticotropic hormone (ACTH), dopamine, serotonin, free thyroxine, thyroid-stim¬ulating hormone, and trace elements manganese, copper, and iron were determined.
Results: It was found out that the cattle with tongue-rolling hyperactivity did not demonstrate changes in red blood picture (HGB, HCT, MCV, MCH, MCHC), white blood picture (WBC, LYM, MON, GRA), blood biochemistry (Ca, P, Mg, TP, Glu, TB, urea, creatine, Cl, Chole, TG, and Alb), AST, ALT, ALP, γ-GT, LDH, and CK activities, Cu, and Fe levels. In the study, increased concentrations of adrenaline, noradrenaline, cortisol, ACTH, and serotonin were established.
Conclusion: The data demonstrating increased levels of adrenaline, noradrenaline, cortisol, and ACTH confirmed the etiological role of environmental stressors in the emergence of oral hyperac¬tivity. Increased serotonin concentrations in the blood suggest that cattle with the stereotype are probably “happy” with tongue rolling. The lack of changes in blood trace elements manganese, cop¬per, and iron allowed excluding their deficiency as a probable cause in the etiology of the disorder.
Disruptive innovations and its impact on public sector banksin India
Authors:   Department of MBA and Research Center, East West Institute of Technology, Bengaluru, India, N Devaraju , B. N Prathap ,   Department of MBA and Research Center, East West Institute of Technology, Bengaluru, India
Published: July 2023

The banking sector has incorporated emerging changes to meet customer requirements and enhance growth.Merger and acquisitions are one of the major changes in the banking industry. Mergers and acquisitions havecreated scope for the adoption of disruptive inventions in banking technology. The adoption of financial technology(FinTech) over recent years has changed the landscape of Indian public sector banks. These disruptive innovationsimprove the performance, efficiency, and quality of services of public sector banks. Technological innovation inbanking has increased the competency level of public sector banks. Customers are interested to adopt thesedisruptive inventions because the electronic mode is having more scope and is convenient for them. This studyidentifies the financial progress and inventions in the banking sector. The study aims to know the changes broughtby disruptive technologies on the services of public sector banks.
Method of anisotropic deformation of elastic materials based on free-form patches
Authors:   Synthesizing Visualization Systems Laboratory, Institute of Automation and Electrometry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russian Federation, Vyatkin Sergey I , Dolgovesov Boris S. ,   Synthesizing Visualization Systems Laboratory, Institute of Automation and Electrometry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russian Federation
Published: July 2023

A method of anisotropic deformation of elastic materials based on free-form patches for biomechanics problems is presented. The method provides an analysis of the anisotropic hyperelasticity of transverse isotropy. For this purpose, fast and efficient Newton solutions are used. An invariant of anisotropic deformation is proposed, with the help of which side states of energy are eliminated at large deformation. The method is also used to restore finite elements. Because of this, it is possible to model large deformations, including for grids containing degenerate elements.
A Review on Pre-service EFL Teacher Identity
Authors: Yang Mei
Published: July 2023

The study of English teacher identity has become one of the hot topics in the field of language teacher education. This study reviews the research on the pre-service English teacher's identity at home and abroad, and discusses the current research situation around the definition of teacher's identity, the characteristics of pre-service English teacher's identity, and the factors that affect the construction of pre-service English teacher's professional identity. The study found that the domestic research on pre-service English teachers is still in its infancy, and the subsequent research should use the multi-source data collection method, carry out more qualitative research, and carry out a large-span tracking research in time when conditions permit, pay more attention to the change and development of pre-service English teachers' identity, at the same time, pay attention to pre-service English teachers' learning in practice schools, and put forward suggestions for the construction of pre-service English teachers' identity, It is expected to provide help for the relevant research of pre-service English teachers in China.
Knowledge Competitive Advantage Evaluation System of Listed Companies of Colleges and Universities
Authors: Xiao Qian
Published: July 2023

Based on the influencing factors,the evaluation index system of knowledge competitive advantage of listed companies of colleges and universities(LCCU) is constructed.Taking 16 LCCU as samples,this paper uses factor analysis method and comprehensive evaluation method to test the evaluation index system of LCCU' knowledge competitive advantage.The analysis results show that using this evaluation index system can scientifically get the position of the knowledge competitive advantage of LCCU,find the related factors leading to the poor knowledge competitive advantage,and help leaders and decision makers improve the knowledge competitive advantage,which has strong theoretical significance and practical promotion value.
The Influence of Zhang Tailei's Family Values on Contemporary Social Atmosphere
Authors: Li Lu , Wu Sirui , Jiang Zhangyin , Ji Bingye , Yuan Zhaoyu
Published: July 2023

This paper takes the family values of Zhang Tailei, one of the "Three Outstanding Figures" in Changzhou City, Jiangsu Province, as a starting point to horizontally study the positive impact of these family values and vertically connect them to General Secretary Xi Jinping's important instructions on fostering good family values. The aim is to elucidate the importance of excellent family values and promote their influence on the present era. Based on historical materials related to Zhang Tailei, this article conducts a series of discussions and arguments, interspersed with quotations from General Secretary Xi Jinping's speeches on family values, to illustrate the nature, content, and impact of good family values.
Research on the Legality of Contract Service Period of University Teachers
Authors: Hu Zhenyang , Pang Ziqiang
Published: July 2023

In practice, the contract service period of university teachers' employment has the tendency of disorder and the problem of non-uniform judicial adjudication scale. The lag and generality of employment contract laws and regulations, the principle of "labor special law is superior to general law" is too vague, and other imperfect employment contract system and laws and regulations are the main reasons for the insufficient legality of the practice of employment contract service period of college teachers. No matter from the Angle of legality or rationality, the employment contract service period should be incorporated into the Labor Contract Law to regulate. The service period of the employment contract of university teachers should meet the requirements of the entity rule of Article 22 of the Labor Contract Law at least in terms of the agreed cause, the agreed period and the amount of breach.
Analysis of Motor Vehicle Exhaust Emission Characteristics based on PEMS in Mountain Cities
Authors: Chen Jiaguo , Dai Xueyang , Zhou Tao , Sun Qinmei
Published: July 2023

Taking a gasoline vehicle in Chongqing as the research object, PEMS testing technology was used to study the exhaust emission characteristics of motor vehicles during driving on roads in the central urban area of Chongqing. The focus was on analyzing the data situation and emission rates of different mountain scenes, and analyzing the carbon emission characteristics of road traffic in Chongqing. Through the analysis and comparison of data, it is shown that in terms of the carbon emissions characteristics of road traffic in Chongqing, through long-term measurement data analysis of comprehensive road conditions in the central urban area of Chongqing, it is found that compared with the general emissions of common small vehicles (100-150 kg/km), the comprehensive carbon emissions of road traffic in Chongqing are significantly higher. This also indicates to some extent that the carbon emissions of road conditions in mountainous cities are higher than those in plain cities.
Problems and Related Suggestions in the Process of Promoting New Urbanization
Authors: Peng Bin
Published: July 2023

Over the past three decades, relying on tourism, real estate, and industrial agglomeration, my country's urbanization has entered a golden age of rapid development. However, over-reliance on land finance reduces the quality of urbanization, increases systemic financial risks in various regions, and is not conducive to the sustainable development of urbanization. According to the national strategic requirements of "mainly recycling the economy" and "developing the county economy", this paper analyzes the shortcomings of the new urbanization construction from the aspects of tourism development, real estate construction and industrial layout, in order to provide guidance for my country's new urbanization road. Provide necessary reference for further development.
How to Teach Pragmatic Functions of English Subjunctive Mood
Authors: Li Jingwen
Published: July 2023

English subjunctive mood, with a variety of pragmatic functions to show English users’ regret, determination and the like, originates from the Old English. In early literature work, English subjunctive mood was widely used. However, nowadays the frequency of English subjunctive mood has declined, far from that in the past. There are several reasons accountable for its decline: (1) English users tend to use easier declarative mood to replace English subjunctive mood. (2) English users ignore some commonly used structures. (3) English users understand its pragmatic functions incomprehensively. Firstly, it briefly introduces English subjunctive mood, covering the definition, classification, and development. Next, it puts much emphasis on the analysis of pragmatic functions of English subjunctive mood, euphemism function and emphasis function. At last, it offers some suggestions on the teaching of English subjunctive mood. This article is a complement to the research on English subjunctive mood, which aims to help English users understand the mood and appropriately use it to show their purposes in different contexts.
The Application of Dialogue Theory in English Teaching in Primary School
Authors: Cao Yao
Published: July 2023

The dialogue theory believes that the essence of English teaching is the dialogue between teachers and students. Dialogue teaching tells us the ultimate goal of teaching is to form a new meaning in the process of collection. Dialogue teaching is the activities to acquire the knowledge and develop the intelligence, forms its own character in the popular form of social dialogue. Through classroom observation and the case analysis, this paper analyzes the objective technique and teaching method of dialogue teaching of primary school English, explore the new meaning of dialogue teaching and how to better implement the dialogue teaching in English classroom.
Analysis of Cultural Presentation in High School English Textbooks and its Teaching Implications
Authors: Yang Jingwen , Yang Yutong
Published: July 2023

The English Curriculum Standards for senior high schools put forward that English education should pay attention to cultivating students' cultural awareness and intercultural communication ability, help them learn, understand and appreciate Chinese and foreign excellent cultures, and strengthen their cultural self-confidence. As an important resource in English learning, teaching materials play an important role in cultivating students' cultural awareness and intercultural communication ability. This study uses the content analysis method and the Framework of Cultural Presentation in English Teaching Materials developed by Zhang Hong and other scholars to analyze the content and mode of cultural presentation in the new edition of FLTRP's senior high school English textbooks. Based on the analysis of the characteristics of the culture of compulsory English textbooks, this study discusses how teachers can better use the textbooks for cultural teaching in the stage of compulsory English courses in high school.