bluuebunny/crossref_metadata_2025 huggingface dataset:
Ações educativas com a enfermagem no contexto de morte
Authors: Pilger Carolina Heleonora , Cogo Silvana Bastos , Sehnem Graciela Dutra , Prates Lisie Alende , Dias Elise de Fátima Rodrigues , Gomes Natália da Silva , Santos Aline Ost dos , Neves Eliane Tatsch
Published: February 2024

Objetivo: Identificar as evidências científicas acerca de ações educativas direcionadas para profissionais e acadêmicos de enfermagem sobre o processo de morte e morrer. Métodos: Revisão integrativa de literatura realizada em outubro de 2022 nas bases de dados LILACS, BDENF, U.S. National Library of Medicine (PubMed/MEDLINE), Web of Science e Scopus, sem recorte temporal. A estratégia de busca guiou-se pela questão: “quais as evidências científicas acerca das ações educativas voltadas para a enfermagem sobre o processo de morte e morrer?”, determinada com a estratégia PICo. Resultados: Foram selecionados 13 estudos para compor o corpus da revisão. Em relação às ações educativas desenvolvidas, destacaram-se oficinas, workshops, cursos, programas de educação para a morte, utilização de material educativo em formato de bundle, disciplina eletiva, exposição de obras de arte, técnica de contar histórias e simulação de alta fidelidade. Considerações finais: O estudo possibilitou identificar as evidências científicas acerca das ações educativas voltadas para os profissionais e acadêmicos de enfermagem abordando o contexto de morte. As principais estratégias utilizadas foram uso de estratégias criativas, método participativo e simulações realísticas.
Traumatic gluteus maximus femoral insertion tear
Authors: Abduldaem Khalid A. , Alyousef Hussain A. , Almuslami Ali Y.
Published: February 2024

With hip fracture dislocation, there is a wide variety of injuries, and one of the least and rarely to be seen is a gluteus maximus femoral insertion tear. We report this case to encourage further sharing of similar cases, establish a treatment protocol, and avoid such potential complications. We present this rare case of a 36-year-old male, a victim of a severe motor vehicle collision, who presented with a head contusion, right gluteus maximus femoral insertion tear, right hip dislocation with closed posterior wall acetabulum fracture, intra-articular incarcerated fragment, and multiple fractures. After the reduction of his hip and splinting of his concomitant fractures and optimization of the general condition, he underwent open reduction internal fixation of the posterior acetabulum wall. Intraoperatively, he found to have a rupture of gluteus maximus and short external rotators for which he had gluteus maximus direct repair to its insertion and partial repair for his severely damaged external rotators. The patient developed a surgical site infection post operation, treated by multiple sessions of irrigation and debridement and culture-based intravenous venous antibiotics for six weeks. At the 7-month outpatient clinical follow-up, the patient function was able to mobilize with a limping gait using a cane and extreme limitation of his abduction, external rotation, and extension due to the development of heterotopic ossification, which could be due to prolonged intensive care unit admission due to head injury or hip external rotators rupture or multiple surgeries that he underwent. This rare finding of gluteus maximus ruptur is the first of a kind in our institute, and such a finding to be considered before treatment of such severe injuries and questioning the need for magnetic resonance imaging for traumatic hip dislocations plus prophylactic treatment of heterotopic ossification to optimize the functional outcome post-operative.
Chemocatalytic Conversion of Dinitrogen to Ammonia Mediated by a Tungsten Complex
Authors: Tuczek Felix , Vogt Anna-Marlene , Engesser Tobias Adrian , Krahmer Jan , Michaelis Niels , Pfeil Mareike , Junge Jannik , Näther Christian , Le Poul Nicolas
Published: February 2024

Whereas molybdenum dinitrogen complexes have played a major role as catalytic model systems of nitrogenase, corresponding tungsten complexes have in most cases found to be catalytically inactive. Herein we present a modified pentadentate tetrapodal (pentaPod) phosphine ligand in which two dimethylphosphine groups of the original PMe2PPh2 ligand have been replaced with phospholanes (Pln). The derived molybdenum complex [Mo(N2)(PPln2PPPh2)] generates 22 and the analogous tungsten complex [W(N2)(PPln2PPPh2)] 7 equivalents of NH3 from N2 in the presence of 180 equiv.s of SmI2/H2O, rendering the latter the first tungsten complex chemocatalytically converting N2 to NH3. In contrast, the parent tungsten complex [W(N2)(PMe2PPh2)] generates ammonia from N2 only in a slightly overstoichiometric fashion. The reasons for these reactivity differences are investigated with the help of spectroscopic and electrochemical methods.
Fragmenstein: predicting protein-ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding–based methodology
Authors: Ferla Matteo P. , Sánchez-García Rubén , Skyner Rachael E. , Gahbauer Stefan , Taylor Jenny C. , von Delft Frank , Marsden Brian D. , Deane Charlotte M.
Published: February 2024

Current strategies centred on either merging or linking initial hits from fragment-based drug design (FBDD) crystallographic screens ignore 3D structural information. We show that an algorithmic approach (Fragmenstein) that ‘stitches’ the ligand atoms from this structural information together can provide more accurate and reliable predictions for protein-ligand complex conformation than existing methods such as pharmacophore-constrained docking. This approach works under the assumption of conserved binding: when a larger molecule is designed containing the initial fragment hit, the common substructure between the two will adopt the same binding mode. Fragmenstein either takes the coordinates of ligands from a experimental fragment screen and stitches the atoms together to produce a novel merged compound, or uses them to predict the complex for a provided compound. The compound is then energy minimised under strong constraints to obtain a structurally plausible compound. This method is successful in showing the importance of using the coordinates of known binders when predicting the conformation of derivative compounds through a retrospective analysis of the COVID Moonshot data. It has also had a real-world application in hit-to-lead screening, yielding a sub-micromolar merger from parent hits in a single round.
Discovering Cell-targeting Ligands and the Cell Surface Receptors via Selection of DNA-encoded Chemical Libraries (DELs) against Cancer Cells without Predefined Targets
Authors: Gui Yuhan , Hou Rui , Huang Yuchen , Zhou Yu , Liu Shihao , Meng Ling , Li Ying , Lam Fong Sang , Wong Clara Shania , Yin Chan Tat , Li Gang , Lu Xiaojie , Li Xiaoyu
Published: February 2024

Small molecule ligands that can specifically recognize the surface of cancer cells have wide utilities in cancer diagnosis and treatment. Screening large combinatorial libraries against live cells is an effective approach to discover cell-targeting ligands. In the past decade, DNA-encoded chemical library (DEL or DECL) has become a powerful technology in drug discovery and been successfully used in ligand discovery against numerous biological targets. However, nearly all DEL selections had predefined targets, whereas completely unbiased DEL selections interrogating the entire cell surface remain underexplored. In this report, we systematically optimized cell-based DEL selection method to perform unbiased selections against cancer cells without predefined targets. A 104.96-million-member DEL was selected against MDA-MB-231 and MCF7, a pair of breast cancer cell lines with high and low metastatic properties, respectively, and cell-specific small molecule ligands and ligand combinations (“clusters”) have been identified. We further show that the ligand cluster could be optimized to improve the binding affinity and applied in cell-targeting applications including cancer photodynamic therapy and targeted drug delivery. Finally, we leveraged the DNA tag of the DEL compounds and identified the cell surface receptor of an individual ligand targeting MDA-MB-231 cells. Overall, this work provides an efficient method for discovering cell-targeting small molecules and demonstrated the potential of DELs as a tool for cancer biomarker discovery.
Coarse-Grained Simulation of mRNA-Loaded Lipid Nanoparticle Self-Assembly
Authors: Grzetic Douglas , Hamilton Nicholas , Shelley John
Published: February 2024

Ionizable lipid-containing lipid nanoparticles (LNPs) have enabled the delivery of RNA for a range of therapeutic applications. In order to optimize safe, targeted and effective LNP-based RNA delivery platforms, an understanding of the role of composition and pH in their structural properties and self-assembly is crucial, yet there have been few computational studies of such phenomena. Here we present a coarse-grained model of ionizable lipid and mRNA-containing LNPs. Our model allows access to the large length- and time-scales necessary for LNP self-assembly, and is mapped and parameterized with reference to all-atom structures and simulations of the corresponding components at compositions typical of LNPs used for mRNA delivery. Our simulations reveal insights into the dynamics of self-assembly of such mRNA-encapsulating LNPs, as well as the subsequent pH change-driven LNP morphology and release of mRNA.
Formation of the oxyl’s potential energy surface by the spectral kinetics of a vibrational mode
Authors: Cuk Tanja , Stewart James , Zayka Paul , Courter Christen
Published: February 2024

One of the most reactive intermediates for oxidative reactions is the oxyl radical, an electron-deficient oxygen atom. The discovery of a new vibration upon photoexcitation of the oxygen evolution catalysis detected the oxyl radical at the SrTiO3 surface. The vibration was assigned to a motion of the sub-surface oxygen underneath the titanium oxyl (Ti-O·-), created upon hole transfer to (or electron extraction from) a hydroxylated surface site. Evidence for such an interfacial mode derived from its spectral shape which exhibited a Fano resonance—a coupling of a sharp normal mode to continu-um excitations. Here, this Fano resonance is utilized to derive precise formation kinetics of the oxyl radical and its associ-ated potential energy surface (PES). From the Fano lineshape, the formation kinetics are obtained from the anti-resonance (the kinetics of the coupling factor), the resonance (the kinetics of the coupled continuum excitations), and the frequency integrated spectrum (the kinetics of the normal mode’s cross-section). All three perspectives yield a logistic function growth with a half-rise of 2.3 ± 0.3 ps and rate of 0.48 ± 0.09 ps. A non-equilibrium transient associated with photoexcitation is separated from the rise of the equilibrated PES. The logistic function characterizes the oxyl coverage at the very initial stages (t~0) to have an exponential growth rate that quickly decreases towards zero as a limiting coverage is reached. Such time-dependent reaction kinetics identify a dynamic activation barrier associated with the formation of a PES and quantify it for an oxyl radical coverage.
Single-benzene-based clickable fluorophores for in vitro and in vivo bioimaging
Authors: Mohanrao Raja , Pinto Clyde S. , Suchenko Andrejus , Clarkson Guy J. , Wills Martin , Roesner Stefan , Shipman Michael , Balasubramanian Mohan K.
Published: February 2024

A series of clickable single-benzene-based fluorophores derived from tetrafluoroterephthalonitrile (4F-2CN) is reported. Fluorophores based on a tetrahydroquinoxaline skeleton (2F-2CN-(β-NH2Ala)) exhibited improved photophysical properties owing to better planarity and conjugation over those with dihydro[1,4]thiazine skeleton (2F-2CN-Cys). These easily produced clickable fluorophores were successfully applied in in vitro and in vivo bioimaging after protein conjugation.
Carboxylate ester-based electrolytes for Na-ion batteries
Authors: Qin Yunan , Choi Seong-Gyu , Mason Lucia , Liu Jing , Li Zongjian , Gao Tao
Published: February 2024

Sodium-ion batteries (SIBs) are promising technology for next-generation energy storage. However, their performance is limited at low temperatures due to the inferior bulk and interfacial resistance of current electrolytes. Here we present a systematic study to evaluate carboxylate ester-based electrolytes for SIB applications, due to their favorable properties (i.e., low melting point, low viscosity and high dielectric constant). The effect of salt, concentration and solvent molecular structure were systematically examined and compared with carbonate-based electrolytes. By combining electrochemical tests with spectroscopic characterizations, the performance of selective carboxylate ester-based electrolytes in hard carbon/Na and Na3V2(PO4)3/Na half-cells were evaluated. We found carboxylates enable high electrolyte conductivities, especially at low temperatures. However, carboxylates alone are inadequate to form a stable interphase due to their high reactivity, which can be addressed by choosing proper anion and forming anion-rich Na+ solvation by increasing salt concentration. Fundamental knowledge on the chemistry-property-performance correlation of this new family of electrolytes was obtained, and their benefits and pitfalls were thoroughly discussed. These discoveries and knowledge shall shed light on the potential of carboxylate ester-based electrolyte and set the foundation for further electrolyte engineering.
Hydrophilic interaction chromatography coupled to ultraviolet photodissociation affords identification, localization, and relative quantitation of glycans on intact glycoproteins
Authors: James Virginia , A.M. van der Zon Annika , Escobar Edwin , F. G. Gargano Andrea , Brodbelt Jennifer
Published: February 2024

Protein glycosylation is implicated in a wide array of diseases, yet glycoprotein analysis remains elusive owing to the extreme heterogeneity of glycans including microheterogeneity at the same amino acid residue (glycosite). Top-down mass spectrometry (MS) allows precise identification and localization of glycans on intact proteins, and coupling top-down MS with chromatography allows time-resolved characterization of glycoforms. Here, we couple ultraviolet photo-dissociation (UVPD) to hydrophilic interaction chromatography (HILIC) to advance the characterization of glycoproteins ranging from 15-34 kDa, offering site localization of glycans, providing sequence coverages up to 93% and relative quantitation of individual glycoforms.
Conceptual integration as a mechanism of formation and intertextual functioning of the “blood, sweat and tears” quotation
Authors: Nefyodova Olena , Shorokhova Polina
Published: February 2024

The article researches into the conceptually underpinned formation and intertextual instantiation of the quotation “blood, sweat and tears”, which has a high reference potential for English-speaking cultures. Conceptual integration processes are key for the emergence of the metaphtonymic meaning of the quotation and its compositional stability, transformation potential and models of intertextual instantiation. The metaphtonymic meaning of this quotation is shaped as a result of conceptual integration of three input spaces, represented by the metaphtonymies BLOOD (for ‘human sacrifice’), SWEAT (for ‘human toil’) and TEARS (for ‘human suffering’), which blend to generate the meaning “backbreaking painful sacrifice”. The specific metaphtonymy underpinning the emergence of the “blood, sweat and tears” quote guides its intertextual instantiation as a result of the processes of conceptual integration following the metaphoric “container” model, verbalized with the verbs “to put”/”to pour”. The quote under analysis is predominantly used in publicistic texts, as such context provides their authors with an opportunity to create a positive association with the personality of Winston Churchill, who used it in his famous speech as a model British Prime-Minister figure and thus enabled its further intertextual functioning. Intertextual instantiation of the “blood, sweat and tears” quotation can be modelled as a multi-scope blend generating multi-dimensional meanings. The adopted research perspective unlocks the explanatory potential of the theory of intertextuality due to the application of the theory of conceptual blending to the processes of formation and intertextual instantiation of the quotation as a referenced phenomenon.
Seed production of spring cereals at the Federal Agrarian Scientific Center of the North-East named after N.V. Rudnitsky
Authors: Zhilin N. A. , Snigireva O. M. , Serkova G. A.
Published: February 2024

Seed production of spring grain crops is the foundation of food security of a modern state. Together with breeding, seed production provides high quality products in the required volume. In the Kirov region, the main producers of original seeds are the Federal Agrarian Scientific Center of the NorthEast named after N.V. Rudnitsky (FASC of the North-East) and Vyatka State Agrotechnological University. FASC of the North-East was reorganized in 2017 to include the North-East Regional Agrarian Research Center, Falyonskaya Breeding Station, Nizhny Novgorod, Mari, Mordovian and Chuvash Agricultural Research Institutes. The FASC of the North-East in Kirov has been producing original seeds of spring grain crops since 1974 by the method of individual-family selection. Original seeds are sold annually to the farms of the Kirov region and other regions of the Russian Federation for use in the nurseries of propagation and super elite. The article analyzes the work of the seed production department for 2019–2021, displays the methodology of obtaining original seeds of spring cereals (oats, wheat, barley), describes the varieties most in demand in the Kirov region. The area of sowing original seeds of spring cereals in the experimental fields of the FASC of the North-East increased by 23.4% during the period under review, reaching 49 ha in 2021. Due to dry weather in 2021, the gross harvest of conditioned spring cereal seed remained at the same level as in 2019 at 60.9 tons. The revenue of the seed division of the FASC of the North-East from the sale of original seeds increased by 47.53% in 2021 compared to 2019 to reach 2.5 million rubles. Original seeds are usually sold to the enterprises that have their own seed production units: AO Agrofirma "Doronichi", APC "Plemzavod "Krasny Oktyabr", APC "Agricultural Artel "Krasnaya Talitsa", OOO "Zurinsky Agrocomplex", OOO "Preduralye". Thus, the Seed Production Department of the FASC of the North-East is an important link in ensuring food security in the region.
Adaptability of buckwheat varieties in the forest-steppe of the Krasnoyarsk Territory
Authors: Serebrennikov Yu. I.
Published: February 2024

The article presents the results of the study of eight buckwheat varieties (Dikul (standard), Dasha, Diana, Design, Zhdanka, Zemlyachka, Natasha, Yashlek) for adaptability in the conditions of the Krasnoyarsk forest-steppe. For this purpose, the following indices were determined for each variety: plasticity coefficient, stability measure, intensity, stability index, variety stability level index, homeostaticity, breeding value of the variety, and adaptability coefficient. The hydrothermal coefficient showed that in 2021 the period from the second ten-day period of May to the first ten-day period of September was dry, in 2020 and 2022 – excessively humidified. The index of environmental conditions was with the sign "–" only in 2022 (–2.942). It was with a "+" sign in 2020 and 2021 (+2.821 and +0.121, respectively). This made it possible to determine the ability of the studied buckwheat varieties to adapt under contrasting conditions. Based on the plasticity coefficient in combination with the measure of stability, the conclusion was made about the ability of the varieties Zemlyachka, Diana, Design, Dikul, Yashlek to give high yield in favorable conditions. But Diana, unlike the other three varieties, in unfavorable conditions can noticeably reduce the yield. The varieties Design, Dikul and Yashlek showed slight yield reduction in the same situation. Dasha and Natasha varieties can produce higher yields under the worst conditions. At the same time variety Dasha is able to give both high and low yields in any conditions, which indicates its high meteorological dependence, especially since the value of the yield of this variety varies little from year to year. At the same time, the Zhdanka variety can sharply reduce yields in some years. The adaptability coefficient showed that Yashlek, Design and Diana have a very high degree of adaptability. Dikul can also be attributed to the varieties with a high ability to adapt to stressful conditions. According to the results of the study, Yashlek is the most adaptive variety (sum of the ranks amounted to 22). Diana, Design, Dasha and Dikul were slightly behind (sum of the ranks was 24–33).
Agrobiological evaluation of the varieties and cultivars of narrow-leafed fodder lupine
Authors: Ageeva P. A. , Potchutina N. A. , Konnova L. V.
Published: February 2024

The reserve for increasing the production of high-protein fodder is the cultivation of leguminous crops, including narrow-leafed lupine (L. angustifolius L.). Protein content in the narrow-leafed lupine seeds is 33–35%, in the dry matter of green mass – 17–19%. It is one of the best forecrops for field crops, as it is able to accumulate 150-300 kg/ha of symbiotic nitrogen in its biomass. The research was conducted in the southwestern zone of the Central Region (Bryansk region). The soil of the fields is sod-podzolic loamy with an average fertility level, pH 5.1–5.6. The weather conditions did not quite meet the biological requirements of the crop. The results of the study of the varieties and cultivars of narrow-leafed lupin in the competitive variety trial 2020–2022 on grain and green mass yield, adaptability, alkaloid con tent and duration of the growing season are presented. The Vityaz variety included in the State Variety Register of the Russian Federation in six regions is taken as a standard. The varieties Bryansky kormovoy and Belorozovy 144 are released in all the regions of the country. Grain yield of different varieties and cultivars varied in the range of 1.59–3.74 t/ha during the years of study. The maximum value was obtained for Hybrid 1246 in 2020. SN 39-20 and Hybrid 1246 (2.86 and 2.76 t/ha) stood out in terms of average grain yield over the 3 years of the trial. The adaptability coefficient was 121 and 117%. The alkaloid content in the seeds of these varieties ranged from 0.010 to 0.046%, with an annual average of 0.028%. Less than 0.04% of alkaloids in the seeds were observed in the varieties SBS 56-15-1, Narrow-leafed 53-02 and Hybrid 1314. The duration of the growing season varied in the range of 78–95 days by year of the trial, the calendar maturity date was the end of July – the 2nd ten-day period of August. All of them are in the "very early" group (71–100 days). The minimum maturity date was observed in 2021 and the maximum in 2020. The varieties Belorozovy 144 and Hybrid 1314 have a longer (6–9 days) vegetation period compared to the standard variety Vityaz. They are characterized by high stature and intense lateral branching. The term of technological readiness for harvesting on green mass came in the first ten days of July. All lupine varieties and cultivars studied in the experiment exceeded the standard in green mass yield by 3.1-8.8 t/ha.
Dry Port Financial Feasibility Analysis Model
Authors: Dewi Nurlaela Kumala , Ishak Riza Fathoni , Ariffien Afferdhy
Published: February 2024

The sea transportation system that is interconnected and provides value for loading and unloading services at the main port of Tanjung Priuk is already over capacity. The establishment of a dry port in Tangerang Regency is expected to facilitate the flow of export and import goods, streamline logistics costs, and solve the dwelling time problem that occurs. The plan to establish the Tangerang Dry Port requires an analysis of the financial feasibility of the investment. The method used to solve this problem is using the Internal Rate of Return (IRR), Net Present Value (NPV), and Payback Period. This feasibility analysis calculation was carried out during pre-construction and after construction so that these calculations can be used as reference material in every decision-making, especially those related to the finances of Tangerang Dry Port. The feasibility analysis calculation uses 3 (three) scenarios, namely for optimistic conditions the IRR value is 28.8%, for moderate conditions the IRR value is 13.6%, and for pessimistic conditions the IRR value is 7.2%. For optimistic conditions the NPV value is 1,716.7 billion, for moderate conditions the NPV value is 697 billion, for optimistic conditions the NPV value is 255 billion. For optimistic conditions the payback period is 6.87 years, for moderate conditions the payback period is 9.26 years, and for pessimistic conditions the payback period is 11.2 years. From the results above, optimistic, and moderate conditions are the most feasible scenarios for developing the Tangerang Dry Port.
The Design of Petilasan Gilanglipuro, Gilangharjo Village, District of Pandak, Bantul Regency
Authors: Setiadi Amos , Binarti Floriberta , Pitaloka Anastasya Diah Ayu
Published: February 2024

Community service activities, located in Gilangharjo Village, district of Pandak, Bantul Regency, aimed to encourage the community to enhance tourist attraction through mentoring in the Gilanglipuro site design. The approach used in this activity was participatory which was elaborated in 3 stages, namely preparation, implementation, and utilization. The preparation stage involved coordination with the Tourism Office and the officials of Gilangharjo Village, as well as identification of village potential data carried out by the university in collaboration with partners. The implementation stage included surveys and focused group discussions (FGDs). The results of this stage in an agreed-upon design concept were expected to become the village icon and a unique tourist destination in the district of Pandak. The utilization stage involved using the activity results to support the development process of the tourist attraction. This community service activity included students’ participation in the Architectural Internship subject. It aligned with the Freedom of Learning Independent Campus (MBKM) concept and encouraged the achievement of the Bantul Regency Medium-Term Development Plan (RPJM), especially in the district of Pandak. The result of those activities was the architectural design of the Gilanglipuro heritage site that accommodated Yogyakarta's cultural values, particularly Bantul, as an area with the title of Bumi Mataram.
MEDICINAL USES, PRESERVATION, PROMOTION AND CRITICAL STUDY OF DASHMOOLA: AN IMPORTANT COMPONENT DESCRIBED IN AYURVEDA SCRIPTURE
Authors: Balkrishna Acharya , Singh Amita , Tyagi Priyanka , Mishra Rajesh Kumar , Joshi Bhaskar , Srivastava Anupam
Published: February 2024

Ayurveda is a scientific method of ancient medicine, in which single and mixed medicines are used multiple times for medicine, in which Dashmoola has its special place. Ashtavarga, Pañcamūla, Trinapanchamoola and Dashmoola are widely used as mixed medicinal components. Dashmoola is made up of two words Dash and Moola, which means "root of ten medicines", i.e., roots of ten medicinal plants are taken in equal proportion. Generally, it is considered to be a combination of the Brihit and Laghu Pañcamūla. Of these ten roots, five roots are of trees known as Bṛhat Pañcamūla and five roots are of bushes known as Laghu Pañcamūla. Bṛhat Pañcamūla includes Bilva [Aegle marmelos (L.) Corrêa], Gambhari (Gmelina arborea Roxb. ex Sm.), Agnimantha (Clerodendrum phlomidis L.f.), Patla [Stereospermum chelonoides (L.f.) DC.], Shyonak [Oroxylum indicum (L.) Kurz] while Laghu Pañcamūla includes Brihati (Solanum indicum L.), Gokharu (Tribulus terrestris L.), Kantakari (Solanum virginianum L.), Prshniparni [Uraria picta (Jacq.) Desv. Ex DC.], Shalaparni [Pleurolobus gangeticus (L.) J.St.-Hil. ex H.Ohashi & K.Ohashi]. Dashmoola is used for the treatment of various diseases, sach as arthritis, asthma, headache, prenatal problems, Parkinson's disease, muscle cramps, lower back pain, etc. In the present review article, habitat, distribution, ecological note, common and vedic nomenclature, flowering and fruiting period, conservation status and medicinal properties of each plant in Dashmoola, have been discussed in detail and Herbarium sheet with field numbers of all plants are available in the Patanjali Research Foundation Herbarium
IMPLEMENTASI ALAT BANTU PENYUSUNAN MODUL DIGITAL DALAM MENGHADAPI 21ST CENTURY LEARNING DI SMK NEGERI 1 CILEUNGSI
Authors: Nugraha Dian , Faizah Safira , Zaenudin M , Hertin RD , Udriyah  , Islam IN
Published: February 2024

Pendidikan memiliki peran utama dalam membangun masyarakat yang adaptif di era globalisasi abad ke-21. Paradigma pembelajaran telah bergeser dari model guru sebagai pusat (teacher-centered) ke pendekatan siswa sebagai pusat (student-centered learning), dengan fokus pada pengembangan keterampilan kritis, kreatif, komunikatif, dan berkolaborasi. Keterbatasan teknologi menjadi penghambat untuk mencapai berbagai keterampilan tersebut. Oleh karena itu, penting bagi guru untuk memanfaatkan teknologi ini untuk menciptakan pembelajaran yang lebih inovatif dan menarik. Tujuan dari kegiatan yang dilakukan penulis adalah untuk meningkatkan efektivitas pembelajaran di SMK Negeri 1 Cileungsi melalui implementasi modul digital, mempersiapkan siswa menghadapi pendidikan abad ke-21. Metode yang diusulkan mencakup: 1) Sosialisasi pendekatan pembelajaran abad ke-21 kepada guru dan siswa; 2) Pelatihan intensif dalam penggunaan modul digital; dan 3) Penyerahan dan pelatihan alat produksi materi pembelajaran berbasis audio visual sebagai sumber belajar yang menarik dan interaktif. Hasil kegitan pengabdian Masyarakat ini meliputi peningkatan pemahaman guru, staf sekolah, dan siswa mengenai konsep pembelajaran abad ke-21. Guru-guru akan mampu mengintegrasikan modul digital ke dalam kurikulum, sementara siswa akan terlibat aktif dalam pembelajaran melalui materi audio visual yang menarik. Evaluasi berkala akan memastikan efektivitas implementasi dan terukurnya kemajuan akademik serta keterampilan siswa dalam menghadapi tantangan pembelajaran modern. Pada akhir pelaksanaan ini penulis juga mendapatkan feedback dari wakil kepala sekolah untuk melanjutkan kegiatan ini ke jurusan lain tidak terbatas untuk Jurusan Teknik Komputer Jaringan. Kesimpulannya, penerapan modul digital dan materi audio visual meningkatkan animo belaja. Karena, mampu menyediakan pembelajaran adaptif sesuai dengan kebutuhan siswa. Saran untuk meningkatkan infrastruktur teknologi di sekolah dan mengevaluasi program secara berkelanjutan diharapkan dapat memperkaya pengalaman pembelajaran di masa mendatang.
PENYULUHAN PRAKTIK KELOMPOK TANI DALAM PENGOLAHAN BAHAN BAKU BIO-PLASTIK DENGAN MEMANFAAFKAN LIMBAH KULIT KOPI
Authors: Berlianti Nindha Ayu , Supriyanto Edy , Rokhmah Dewi
Published: February 2024

Desa Pace merupakan salah satu penghasil kopi terbesar di Kabupaten Jember. Penduduk desa pace mayoritas sebagai petani kopi yang tergabung dalam gabungan kelompok tani yang beranggotakan 10 kelompok tani dengan masing-masing per/kelompok kurang lebih 10-20 orang petani. Pada musim panen kopi, sisa hasil limbah kulit kopi masih belum banyak dimanfaatkan dengan maksimal, umumnya sisa hasil pertanian kopi dijual dengan harga yang sangat murah yakni sekitar 8 ribu per/karung besar. Hal ini menjadikan alasan utama kami sebagai tim pengabdian untuk memberikan nilai tambah pada limbah kulit kopi dengan memberikan pelatihan dan praktik dalam meningkatkan keterampilan petani kopi dalam mengelola dan mengolah limbah kulit kopi. Kegiatan diawali dengan permintaan mitra untuk memberikan penyuluhan, praktik serta pendampingan dalam mengelola dan mengolah limbah kulit kopi pasca panen. Partisipatif  dalam kegiatan pengabdian melibatkan komunitas petani kopi aktif yang berjumlah 50 petani. Hasil kegiatan ini ialah anggota gapoktan memiliki pengetahuan dan keterampilan dalam mengelola dan mengolah limbah kulit kopi menjadi bahan baku tepung kulit kopi yang nantinya dapat dikarakterisasi lebih lanjut menjadi bio plastik, bio pellet, campuran pakan ternak, kompos blok, cascarapeat block, bio pop,  bio briket dan produk olahan lainnya yang memiliki nilai tambah sehingga dapat memberikan penghasilan tambahan khususnya para petani kopi di desa pace kecamatan silo kabupaten jember. Melalui kegiatan pengabdian masyarakat yang dilakukan, harapannya mampu meningkatkan ketrampilan dan pendapatan mitra dalam mengelola dan mengolah limbah kulit kopi menjadi bahan baku tepung kulit kopi.
PELATIHAN PEMBUATAN LULUR TRADISIONAL DARI DAUN BIDARA (Ziziphus spina christi L.) DI DESA TANJUNG BARU, OGAN ILIR, SUMATRA SELATAN
Authors: Hariani Poedji Loekitowati , Fatma  , Ahadito Bijak Rihandi , Said Muhammad , Rohendi Dedi
Published: February 2024

Perawatan kulit dan wajah telah dikenal sejak dahulu kala dan telah menjadi bagian dari kebudayaan masyarakat Indonesia. Masyarakat semakin menyadari bahaya kosmetika dari bahan kimia. Interaksi bahan kimia dengan kulit seringkali menimbulkan masalah seperti iritasi, komedo, kulit semakin kering, bahkan kulit menghitam dan mengelupas. Seiring dengan konsep back to nature, yaitu kembali menggunakan bahan alami untuk merawat kecantikan kulit maka perlu dikembangkan potensi lokal sebagai bahan baku perawatan kulit. Kegiatan pengabdian masyarakat yang dilakukan di desa Tanjung Baru kecamatan Indralaya Utara, Ogan Ilir bertujuan untuk memberikan pelatihan pembuatan lulur tradisional untuk perawatan wajah dan kulit dari daun bidara. Peserta kegiatan adalah ibu-ibu dan remaja putri, karena mereka yang sering melakukan perawatan tersebut. Kegiatan berupa penyuluhan tentang pentingnya perawatan kulit dan wajah, pelatihan cara pembuatan lulur dari daun bidara, cara penggunaan lulur dan penyimpanan. Selanjutnya dilakukan evaluasi melalui Pre-test, Pos-Tes dan kuesioner. Hasil kegiatan menunjukkan adanya peningkatan pemahaman peserta kegiatan tentang perawatan kulit dan wajah, meningkatnya pengetahuan tentang bahaya kosmetik dari bahan kimia dan meningkatnya pengetahuan penggunaan bahan nabati sebagai bahan baku lulur dari semula 35,33 % menjadi 95,33 %. Berdasarkan hasil kuesioner menunjukkan bahwa peserta kegiatan menyukai produk lulur yang dihasilkan. Hasil uji tingkat kesukaan menunjukkan sebanyak 86,68 % peserta sangat suka terhadap 5 jenis tingkat kesukaan yang diujikan yaitu aroma, tekstur, warna, kekentalan dan kenyamanan lulur dari daun bidara. Tidak ada peserta yang menyatakan tidak suka, kurang suka dan netral. Hasil kegiatan menunjukkan lulur dari daun bidara diterima dengan baik, peserta juga antusias melanjutkan membuat lulur untuk perawatan kulit dan wajah.
Studi Kualitatif: Profil Pelajar Pancasila Melalui Media Kolase Ditinjau Dari Kreativitas Pada Anak Berkebutuhan Khusus
Authors: Cotimah Nuri , Sari Nurratri Kurnia , Suswandari Meidawati
Published: February 2024

Penelitian ini dilatarbelakangi oleh keefektifan profil pelajar pancasila melalui kreativitas peserta didik Anak Berkebutuhan Khusus melalui media kolase. Tujuan penelitian ini adalah menggambarkan profil pelajar Pancasila melalui media kolase yang ditinjau dari kreativitas anak berkebutuhan khusus. Jenis penelitian ini menggunakan pendekatan kualitatif deskriptif melalui strategi penelitian studi kasus. Kegiatan penelitian ini dilakukan di kelas pengembangan Sanggar Inklusi Tunas Bangsa Nguter dengan menggunakan media pembelajaran kolase melalui paper plate. Hasil penelitian menunjukkan bahwa dengan kegiatan pembelajaran dengan media kolase yang ditinjau dari kreativitas dapat dihasilkan bahwa pada tahapan  perencanaan, tahapan pelaksanaan, dan tahapan evaluasi yang dapat menghasilkan data kreativitas berupa kognitif (orisinalitas, fleksibelitas, kelancaran, dan elaborasi) dengan presentase tertinggi 93,75% dan non-kognitif (rasa ingin tahu, imajinatif, tertantang, sikap berani, dan sikap menghargai) dengan presentase tertinggi 95% sehingga dapat disimpulkan bahwa peserta didik menggunakan media pembelajaran kolase ditinjau dari kreativitas dapat berkembang sesuai dengan harapan dan sangat berkembang sehingga dapat mencapai tujuan pembelajaran profil pelajar Pancasila melalui media kolase dari bahan paper plate/piring kertas dan potongan gambar dalam peningkatan kreativitas belajar pada anak berkebutuhan khusus.
USO DO CÃO DE AUXÍLIO AO TRABALHO POLICIAL ATRAVÉS DA ODOROLOGIA FORENSE
Authors: RODRIGUES TIAGO CABRAL
Published: February 2024

Resumo: O uso de cães no auxílio ao trabalho policial vem sendo cada vez mais útil para diversas finalidades. Cães são empregados em diversas áreas, sejam na localização de drogas, explosivos, armas, pessoas desaparecidas, resgates, nos casos em que há possibilidade da existência de corpos enterrados em locais de desastres naturais e a localização de cadáveres. Os cães também são utilizados por forças de segurança em diversos países do mundo para auxílio em investigações criminais e esse auxílio tem sido muito útil nas ciências forenses. Em uma cena de crime, por exemplo, podemos fazer uso do cão através da odorologia forense que usa a captação de odores deixados no local, às vezes chamada de “evidência esquecida”, em pegadas, impressões digitais, objetos usados pelo criminoso, etc. A odorologia forense é, com auxílio dos cães, a capacidade de coletar o referido odor humano diretamente na cena do crime, a fim de estabelecer uma associação com o odor do suspeito. Isso é possível graças à capacidade olfativa dos cães, que discrimina e diferencia esses odores sob um protocolo de alto rigor e treinamento feito por especialistas em cães de faro.Palavras-chave: Odorologia, Forense, Cena do Crime, Cão
ENGENHARIA SOCIAL: UMA ANÁLISE DE AMEÇAS E CUIDADOS NO MUNDO CORPORATIVO.
Authors:   , Hodnik Carlos Eduardo
Published: February 2024

A engenharia social é a arte de manipular pessoas a fim de contornar dispositivos de Segurança.
Trata-se de uma técnica que consiste em obter as informações necessárias para realização do
ataque, direcionadas aos detentores da informação, através de contato por telefone, correio
eletrônico, contato direto, entre outros meios. Diante deste conceito, o presente artigo tem como
objetivo apresentar os resultados de análise sobre engenharia social, suas ameaças e cuidados
no mundo corporativo. Foi realizado a aplicação de questionário aos funcionários de diversas
empresas em diversos segmentos, os procedimentos tratados sobre a engenharia social inseridos
na segurança da informação. A partir da pesquisa realizada, constatou-se que a engenharia
social é uma ameaça que não necessita de conhecimentos técnicos e nem de grandes
investimentos para a proteção da segurança da informação, necessita de conhecimentos dos
métodos e técnicas de como se defender de um engenheiro social que tem como objetivo acessar
as informações sigilosas. Conclui-se que deverá ser despertado o interesse ao usuário para esse
perigo, e conscientizá-lo da importância da sua informação.
GuiADP
Authors: Borges Renata Campos de Sousa , Alves Guilherme Henrique Nascimento , Ferreira Ilma Pastana , Caldato Milena Coelho Fernandes
Published: February 2024

.
Libélulas
Authors: Catâneo Dayana Tamiris Brito dos Santos , Santos Tauanne Alves Putumujú , Pereira Fabrícia Simões , Costa Anna Cristyna Tavares , Oliveira Marcela Alvares , Doria Carolina Rodrigues da Costa , Silveira Maria Aurea Pinheiro de Almeida
Published: February 2024

O livro "Libélulas: bioindicadores" aborda de forma abrangente e informativa o fascinante mundo das libélulas, insetos da ordem Odonata. Ao longo das suas páginas, são explorados temas como a importância das libélulas como bioindicadores ambientais, sua relação com o ambiente e a necessidade de preservação dos ecossistemas aquáticos onde habitam. São destacadas as características anatômicas das libélulas, seu ciclo de vida, alimentação e reprodução. Além disso, o livro ressalta a relevância do biomonitoramento realizado por esses insetos e como a preservação dos igarapés e áreas naturais é essencial para garantir a sobrevivência desses seres incríveis. Com ilustrações encantadoras e informações detalhadas, o livro convida o leitor a conhecer e apreciar a beleza e importância das libélulas, incentivando ações de conservação e respeito ao meio ambiente.
AVALIAÇÃO EDUCACIONAL E FORMAÇÃO DE PROFESSORES: um percurso histórico
Authors: Carvalho Wirla Risany Lima
Published: February 2024

Produto de uma pesquisa, durante estudo de Mestrado
em Avaliação Educacional, na Universidade Federal do Ceará,
entre os anos de 2010 a 2012, este livro abrange o percurso
histórico da evolução conceitual da avaliação educacional,
desde os seus primórdios, quando a avaliação ainda não
tinha toda esta relevância educacional. Em busca de uma
compreensão da história da Avaliação Educacional, os estudos
partiram do conceito de medida como fundamento da avaliação.
Durante a exposição desta revisão de literatura são apresentadas
as concepções e olhares da avaliação educacional, levando
em consideração alguns contextos e autores, nacionais e
internacionais.
Neste, a legislação educacional também foi explorada para
demonstrar qual visão de avaliação educacional preconiza,
assim como as colocações de alguns autores acerca de uma
avaliação como componente do ato pedagógico.
A avaliação da aprendizagem no Ensino Superior também
foi um ponto de destaque nesse livro, demonstrando quais
visões estão presentes nas práticas avaliativas e discussões no
meio acadêmico.
Para finalizar, uma seção demonstrando brevemente
algumas relações da avaliação com os paradigmas educacionais,
as teorias pedagógicas e as tendências que permeiam a Educação.
A bibliometric analysis covering the relevant literature on science anxiety over two decades
Authors: Khafizova Aygul A. , Zhdanov Sergei P. , Beltyukova Oksana V. , Lapidus Natalia I. , Grebenshchikova Ludmila Y. , Lushchik Irina V.
Published: February 2024

This study aimed to examine publications related to science anxiety to contribute to developing relevant literature. A bibliometric analysis was conducted on 71 articles published between 2003 and 2022 from the Scopus database. The analysis examined the bibliographic links between the sources, authors, countries, and publications through the VOSviewer software. The results regarding keyword analysis showed that the five most frequently used keywords in the selected articles are anxiety, science anxiety, students, self-efficacy, and education. The results also showed that 80% of research papers on science anxiety, among the top 10 highest cited publications, were conducted in the USA. All of the top-10 publications were published in journals that have published articles in education literature for a long time. In addition, the results indicated that half of the publications also used psychology education journals. Furthermore, the bibliographic coupling of the authors showed that research teams from the USA authored the most publications on science anxiety. In light of the results, recommendations for future studies are made in conclusion.
Digital Competence in University Students: A Comparison between Spain and Italy
Authors: LLorent-Vaquero Mercedes , Agreda-Montoro Miriam , Tallón Rosales Susana
Published: February 2024

Digital competence today is one of the key competences for the development of people in society and a special relevance in Higher Education. This study presents a comparison between university students from Spain and Italy on the level of competence in the use of ICT and the Internet to search and process information. A quantitative methodology was used, through which university students from Italy and Spain were asked to fill in a questionnaire on digital competence (n = 686). The results confirm that students have a digital competence that allows them to use ICT in its elementary dimensions, however they have a low digital competence for the design and creation of content, so they have a consumer role compared to that of a prosumer. The last part of the study discussed possible explanations for the study's findings and suggestions for improving the education of college students.
Accounting for digital currencies: A review of challenges and standardization efforts
Authors: Esther Chinonye Ugochukwu  , Titilola Falaiye  , Noluthando Zamanjomane Mhlongo  , Ekene Ezinwa Nwankwo
Published: February 2024

In the wake of the Fourth Industrial Revolution, the ascent of digital currencies heralds a transformative era in the global financial landscape, challenging traditional paradigms of currency, commerce, and regulation. This study delves into the emergence, integration, and implications of digital currencies within the global economy, with a particular focus on the accounting and regulatory challenges they pose. Through a meticulous examination of global adoption trends, technological advancements, and the historical evolution of digital currencies, this paper aims to dissect the multifaceted impact of these novel financial instruments on financial reporting, transparency, and regulatory frameworks. Employing a qualitative literature review strategy alongside thematic analysis, the study identifies key challenges in volatility, valuation, transaction anonymity, and the pressing need for standardized accounting practices to enhance comparability and transparency in financial reporting. The investigation extends to the scrutiny of current accounting standards, regulatory responses, and the concerted efforts towards standardization and best practices in digital currency accounting. The findings underscore a critical juncture for practitioners and regulators alike, navigating the intricate accounting landscape shaped by digital currencies. The study culminates in advocating for adaptive regulatory frameworks and standardized accounting practices, emphasizing the necessity of international collaboration and continuous research to harness the potential of digital currencies while safeguarding financial stability and integrity. Recommendations for future research and policy development are proposed to address the evolving dynamics of digital currencies, aiming to support innovation, ensure financial transparency, and maintain regulatory efficacy in the digital age.
A review on multi objective optimization problems and advancement on its solutions
Authors: Debendranath Rout  , Bijoy kumar Nand a  , Tumbanath Samantara
Published: February 2024

A plenty of literatures are available for finding solution of optimization problem of single objective. Very few literatures are available for finding solution of optimization problem with multi objective optimization. Many researchers analysing multi objective problems by treating as single objective, keeping rest of variables as constant. With the tremendous rise of innovations in evolutionary computation, that has added feathers to Multi Objective Optimization techniques.