bluuebunny/crossref_metadata_2025 huggingface dataset:
Micromechanics-Based Modeling of SiC/SiC Ceramic Matrix Composites and Structures
Authors: Mital Subodh , Arnold Steven , Bednarcyk Brett , Pineda Evan
Published: June 2023

The behavior and response of ceramic matrix composites (CMCs), in particular silicon carbide fiber reinforced silicon carbide matrix (SiC/SiC), is affected by many factors such as variation of fiber volume fraction, residual stresses resulting from processing of the composites at high temperature, random microstructures, and the presence of matrix flaws (e.g., voids, pores, cracks etc.) as well as general material nonlinearity and heterogeneity that occurs randomly in a composite. Residual stresses arising from the phase change of constituents are evaluated in this paper and it is shown that they do influence composite strength and need to be properly accounted for. Additionally, the microstructures (location of fiber centers, coating thickness etc.) of advanced CMCs are usually disordered (or random) and fiber diameter and strength typically have a distribution. They rarely resemble the ordered fiber packing (square, rectangular, or hexagonal) that is generally assumed in micromechanics-based models with periodic boundary conditions for computational expediency. These issues raise the question of how should one model such systems effectively? Can an ordered hexagonal packed repeating unit cell (RUC) accurately represent the random microstructure behavior? How many fibers need to be included to enable accurate representation? Clearly, the number of fibers within an RUC must be limited to insure a balance between accuracy and efficiency. NASA’s in-house micromechanics-based code MAC/GMC provides a framework to analyze such RUCs for the overall composite behavior and the FEAMAC computer code provides linkage of MAC/GMC to the commercial FEA code, ABAQUS. The appropriate level of discretization of the RUC as well as the analysis method employed, i.e., Generalized Method of Cells (GMC) or High Fidelity Generalized Method of Cells (HFGMC), is investigated in this paper in the context of a unidirectional as well as a cross-ply laminated CMC. Results including effective composite properties, proportional limit stress (an important design parameter) and fatigue are shown utilizing both GMC as well as HFGMC. Finally, a few multiscale analyses are performed on smooth bar test coupons as well as test coupons with features such as open-hole and double notches using FEAMAC. Best practices and guidance are provided to take these phenomena into account and keep a proper balance between fidelity (accuracy) and efficiency. Following these guidelines can account for important physics of the problem and provide significant advantages when performing large multiscale composite structural analyses. Finally, to demonstrate the multiscale analysis framework, a CMC gas turbine engine vane structure is analyzed involving a progressive damage model.
The Variability of Lumbar Sequential Motion Patterns: Observational Study
Authors: Caelers Inge , Boselie Toon , van Hemert Wouter , Rijkers Kim , De Bie Rob , van Santbrink Henk
Published: June 2023

Background

Physiological motion of the lumbar spine is a topic of interest for musculoskeletal health care professionals since abnormal motion is believed to be related to lumbar complaints. Many researchers have described ranges of motion for the lumbar spine, but only few have mentioned specific motion patterns of each individual segment during flexion and extension, mostly comprising the sequence of segmental initiation in sagittal rotation. However, an adequate definition of physiological motion is still lacking. For the lower cervical spine, a consistent pattern of segmental contributions in a flexion-extension movement in young healthy individuals was described, resulting in a definition of physiological motion of the cervical spine.

Objective

This study aimed to define the lumbar spines’ physiological motion pattern by determining the sequence of segmental contribution in sagittal rotation of each vertebra during maximum flexion and extension in healthy male participants.

Methods

Cinematographic recordings were performed twice in 11 healthy male participants, aged 18-25 years, without a history of spine problems, with a 2-week interval (time point T1 and T2). Image recognition software was used to identify specific patterns in the sequence of segmental contributions per individual by plotting segmental rotation of each individual segment against the cumulative rotation of segments L1 to S1. Intraindividual variability was determined by testing T1 against T2. Intraclass correlation coefficients were tested by reevaluation of 30 intervertebral sequences by a second researcher.

Results

No consistent pattern was found when studying the graphs of the cinematographic recordings during flexion. A much more consistent pattern was found during extension, especially in the last phase. It consisted of a peak in rotation in L3L4, followed by a peak in L2L3, and finally, in L1L2. This pattern was present in 71% (15/21) of all recordings; 64% (7/11) of the participants had a consistent pattern at both time points. Sequence of segmental contribution was less consistent in the lumbar spine than the cervical spine, possibly caused by differences in facet orientation, intervertebral discs, overprojection of the pelvis, and muscle recruitment.

Conclusions

In 64% (7/11) of the recordings, a consistent motion pattern was found in the upper lumbar spine during the last phase of extension in asymptomatic young male participants. Physiological motion of the lumbar spine is a broad concept, influenced by multiple factors, which cannot be captured in a firm definition yet.

Trial Registration

ClinicalTrials.gov NCT03737227; https://clinicaltrials.gov/ct2/show/NCT03737227

International Registered Report Identifier (IRRID)

RR2-10.2196/14741
Short-Term Findings From Testing EPIO, a Digital Self-Management Program for People Living With Chronic Pain: Randomized Controlled Trial
Authors: Bostrøm Katrine , Børøsund Elin , Eide Hilde , Varsi Cecilie , Kristjansdottir Ólöf Birna , Schreurs Karlein M G , Waxenberg Lori B , Weiss Karen E , Morrison Eleshia J , Stavenes Støle Hanne , Cvancarova Småstuen Milada , Stubhaug Audun , Solberg Nes Lise
Published: June 2023

Background

Chronic pain conditions involve numerous physical and psychological challenges, and while psychosocial self-management interventions can be of benefit for people living with chronic pain, such in-person treatment is not always accessible. Digital self-management approaches could improve this disparity, potentially bolstering outreach and providing easy, relatively low-cost access to pain self-management interventions.

Objective

This randomized controlled trial aimed to evaluate the short-term efficacy of EPIO (ie, inspired by the Greek goddess for the soothing of pain, Epione), a digital self-management intervention, for people living with chronic pain.

Methods

Patients (N=266) were randomly assigned to either the EPIO intervention (n=132) or a care-as-usual control group (n=134). Outcome measures included pain interference (Brief Pain Inventory; primary outcome measure), anxiety and depression (Hospital Anxiety and Depression Scale), self-regulatory fatigue (Self-Regulatory Fatigue 18 scale), health-related quality of life (SF-36 Short Form Health Survey), pain catastrophizing (Pain Catastrophizing Scale), and pain acceptance (Chronic Pain Acceptance Questionnaire). Linear regression models used change scores as the dependent variables.

Results

The participants were primarily female (210/259, 81.1%), with a median age of 49 (range 22-78) years and a variety of pain conditions. Analyses (n=229) after 3 months revealed no statistically significant changes for the primary outcome of pain interference (P=.84), but significant reductions in the secondary outcomes of depression (mean difference −0.90; P=.03) and self-regulatory fatigue (mean difference −2.76; P=.008) in favor of the intervention group. No other statistically significant changes were observed at 3 months (all P>.05). Participants described EPIO as useful (ie, totally agree or agree; 95/109, 87.2%) and easy to use (101/109, 92.7%), with easily understandable exercises (106/109, 97.2%).

Conclusions

Evidence-informed, user-centered digital pain self-management interventions such as EPIO may have the potential to effectively support self-management and improve psychological functioning in the form of reduced symptoms of depression and improved capacity to regulate thoughts, feelings, and behavior for people living with chronic pain.

Trial Registration

ClinicalTrials.gov NCT03705104; https://clinicaltrials.gov/ct2/show/NCT03705104
Extractive Clinical Question-Answering With Multianswer and Multifocus Questions: Data Set Development and Evaluation Study (Preprint)
Authors: Moon Sungrim , He Huan , Jia Heling , Liu Hongfang , Fan Jungwei Wilfred
Published: June 2023

BACKGROUND

Extractive question-answering (EQA) is a useful natural language processing (NLP) application for answering patient-specific questions by locating answers in their clinical notes. Realistic clinical EQA can yield multiple answers to a single question and multiple focus points in 1 question, which are lacking in existing data sets for the development of artificial intelligence solutions.

OBJECTIVE

This study aimed to create a data set for developing and evaluating clinical EQA systems that can handle natural multianswer and multifocus questions.

METHODS

We leveraged the annotated relations from the 2018 National NLP Clinical Challenges corpus to generate an EQA data set. Specifically, the 1-to-N, M-to-1, and M-to-N drug-reason relations were included to form the multianswer and multifocus question-answering entries, which represent more complex and natural challenges in addition to the basic 1-drug-1-reason cases. A baseline solution was developed and tested on the data set.

RESULTS

The derived RxWhyQA data set contains 96,939 QA entries. Among the answerable questions, 25% of them require multiple answers, and 2% of them ask about multiple drugs within 1 question. Frequent cues were observed around the answers in the text, and 90% of the drug and reason terms occurred within the same or an adjacent sentence. The baseline EQA solution achieved a best F1-score of 0.72 on the entire data set, and on specific subsets, it was 0.93 for the unanswerable questions, 0.48 for single-drug questions versus 0.60 for multidrug questions, and 0.54 for the single-answer questions versus 0.43 for multianswer questions.

CONCLUSIONS

The RxWhyQA data set can be used to train and evaluate systems that need to handle multianswer and multifocus questions. Specifically, multianswer EQA appears to be challenging and therefore warrants more investment in research. We created and shared a clinical EQA data set with multianswer and multifocus questions that would channel future research efforts toward more realistic scenarios.
Factors Influencing Physicians' Acceptance of Computerized Clinical Decision Support Systems: A Study on Career Stage and Experience (Preprint)
Authors: Yoo Suyoung , Song Yeejun , jung namju , Cha wonchul
Published: June 2023

BACKGROUND

Computerized clinical decision support systems (CDSS) have garnered attention in recent years to enhance clinical decision making and improve patient outcomes. However, their impact on healthcare providers, patient outcomes, and costs remains uncertain.

OBJECTIVE

This study aimed to investigate the factors influencing physicians' acceptance of CDSS based on their career stage and level of experience. Specifically, we sought to understand the disparity between test prescriptions and algorithm predictions made by physicians, the expectations regarding examination prescriptions from physicians who had solely reviewed patients' medical records, the differences between predictions made by physicians who had only reviewed medical records and the algorithm's predictions, and the degree of acceptance of algorithmic results based on physicians' experience.

METHODS

The study was conducted at an academic tertiary hospital in Seoul and involved clinicians working in the Emergency Department. The CANE system, a CDSS deployment platform, was utilized to provide recommendations for appropriate orders and examinations to patients visiting the emergency department.

RESULTS

Our findings revealed no significant differences in average scores between specific groups and the algorithm prior to exposure to the CANE algorithm. However, notable variations in average scores were observed among the three groups of medical professionals. Following exposure to CANE, the professor group exhibited a significant increase in average scores, while the resident group demonstrated a significant decrease. Overall, no statistically significant differences were found in the average scores among the three groups after exposure to CANE.

CONCLUSIONS

By gaining a comprehensive understanding of the factors influencing physicians' acceptance and adoption of CDSS, this study seeks to provide valuable insights for the development and implementation of CDSS in clinical practice, ultimately aiming to enhance patient outcomes.
Social Media Use Among Radiation Oncology Residents in Turkey (Preprint)
Authors: Yilmaz Tugba , Gur Bengisu , Kanyilmaz Gul , Dagoglu Nergiz
Published: June 2023

BACKGROUND

The number of literature to assess the characteristics of social media usage in medical environments has been increasing.

OBJECTIVE

In this survey study, we aimed to characterize social media use amongst radiation oncology residents in Turkey.

METHODS

An anonymous 33-question survey was sent to 150 radiation oncology residents via e-mail and messages. Opinions regarding their social media use were assessed. Descriptive analyses, chi-square and logistic regression tests were used for statistical analyses in IBM SPSS Statistics 23 program.

RESULTS

84 residents completed the questionnaire. 36.9% of respondents admitted using social media more than 3 hours per day over the past week and 66.7% spent less than the quater of the total amount of social media time for professional purposes. Residents had connections with their radiation oncology attendings known in person on social media (P=.02). Those participating in radiation oncology related discussions on social media (P=.04), and those connecting with fellow radiation oncology residents on social media (P=.048) were more likely to feel a sense of belonging in the radiation oncology community. 42.9% agreed that social media improved their clinical skills in cancer care and 34.5% felt that social media could be helpful for career development. The minority (10.7%) of the respondents felt pressure to use social media for professional purposes and 14.7% found it challenging to set boundaries between personal and professional lives on social media.

CONCLUSIONS

The usage of social media among radiation oncology residents was helpful in many aspects such as creating a sense of belonging in the radiation oncology community, learning novel educational contents and building their careers. However, possible adverse effects are emphasized as well. Social media use amongst Turkish radiation oncology residents still requires further research to optimize its routine use.
Oral Cannabidiol for Seborrheic Dermatitis in Patients With Parkinson Disease: Randomized Clinical Trial (Preprint)
Authors: Weber Isaac , Zagona-Prizio Caterina , Sivesind Torunn E , Adelman Madeline , Szeto Mindy D , Liu Ying , Sillau Stefan H , Bainbridge Jacquelyn , Klawitter Jost , Sempio Cristina , Dunnick Cory A , Leehey Maureen A , Dellavalle Robert P
Published: June 2023

BACKGROUND

Seborrheic dermatitis (SD) affects 18.6%-59% of persons with Parkinson disease (PD), and recent studies provide evidence that oral cannabidiol (CBD) therapy could reduce sebum production in addition to improving motor and psychiatric symptoms in PD. Therefore, oral CBD could be useful for improving symptoms of both commonly co-occurring conditions.

OBJECTIVE

This study investigates whether oral CBD therapy is associated with a decrease in SD severity in PD.

METHODS

Facial photographs were collected as a component of a randomized (1:1 CBD vs placebo), parallel, double-blind, placebo-controlled trial assessing the efficacy of a short-term 2.5 mg per kg per day oral sesame solution CBD-rich cannabis extract (formulated to 100 mg/mL CBD and 3.3 mg/mL THC) for reducing motor symptoms in PD. Participants took 1.25 mg per kg per day each morning for 4 ±1 days and then twice daily for 10 ±4 days. Reviewers analyzed the photographs independently and provided a severity ranking based on the Seborrheic Dermatitis Area and Severity Index (SEDASI) scale. Baseline demographic and disease characteristics, as well as posttreatment SEDASI averages and the presence of SD, were analyzed with 2-tailed t tests and Pearson χ2 tests. SEDASI was analyzed with longitudinal regression, and SD was analyzed with generalized estimating equations.

RESULTS

A total of 27 participants received a placebo and 26 received CBD for 16 days. SD severity was low in both groups at baseline, and there was no treatment effect. The risk ratio for patients receiving CBD, post versus pre, was 0.69 (95% CI 0.41-1.18; P=.15), compared to 1.20 (95% CI 0.88-1.65; P=.26) for the patients receiving the placebo. The within-group pre-post change was not statistically significant for either group, but they differed from each other (P=.07) because there was an estimated improvement for the CBD group and an estimated worsening for the placebo group.

CONCLUSIONS

This study does not provide solid evidence that oral CBD therapy reduces the presence of SD among patients with PD. While this study was sufficiently powered to detect the primary outcome (efficacy of CBD on PD motor symptoms), it was underpowered for the secondary outcomes of detecting changes in the presence and severity of SD. Multiple mechanisms exist through which CBD can exert beneficial effects on SD pathogenesis. Larger studies, including participants with increased disease severity and longer treatment periods, may better elucidate treatment effects and are needed to determine CBD’s true efficacy for affecting SD severity.

CLINICALTRIAL

ClinicalTrials.gov NCT03582137; https://clinicaltrials.gov/ct2/show/NCT03582137
A Novel Evaluation Model for Assessing ChatGPT on Otolaryngology–Head and Neck Surgery Certification Examinations: Performance Study (Preprint)
Authors: Long Cai , Lowe Kayle , Zhang Jessica , Santos André dos , Alanazi Alaa , O'Brien Daniel , Wright Erin D , Cote David
Published: June 2023

BACKGROUND

ChatGPT is among the most popular large language models (LLMs), exhibiting proficiency in various standardized tests, including multiple-choice medical board examinations. However, its performance on otolaryngology–head and neck surgery (OHNS) certification examinations and open-ended medical board certification examinations has not been reported.

OBJECTIVE

We aimed to evaluate the performance of ChatGPT on OHNS board examinations and propose a novel method to assess an AI model’s performance on open-ended medical board examination questions.

METHODS

Twenty-one open-ended questions were adopted from the Royal College of Physicians and Surgeons of Canada’s sample examination to query ChatGPT on April 11, 2023, with and without prompts. A new model, named Concordance, Validity, Safety, Competency (CVSC), was developed to evaluate its performance.

RESULTS

In an open-ended question assessment, ChatGPT achieved a passing mark (an average of 75% across 3 trials) in the attempts and demonstrated higher accuracy with prompts. The model demonstrated high concordance (92.06%) and satisfactory validity. While demonstrating considerable consistency in regenerating answers, it often provided only partially correct responses. Notably, concerning features such as hallucinations and self-conflicting answers were observed.

CONCLUSIONS

ChatGPT achieved a passing score in the sample examination and demonstrated the potential to pass the OHNS certification examination of the Royal College of Physicians and Surgeons of Canada. Some concerns remain due to its hallucinations, which could pose risks to patient safety. Further adjustments are necessary to yield safer and more accurate answers for clinical implementation.
Global trends in obesity and gut flora from 2012 to 2022 based on CiteSpace and VOSviewer (Preprint)
Authors: Yue Jia , Zhou Ying , Tian Lele , Wu Jing , Teng Jingquan , Qian Jinping , Xu Mingyao , Su Wenyuan , Pei Lingyun , Zhang Shunan , Li Jinjuan , Zhang Yan
Published: June 2023

BACKGROUND

Obesity is a metabolic disease and an independent risk factor for several diseases such as hypertension, cardiovascular disease, and diabetes mellitus. Gut flora has been found to be a hot topic of interest in recent years in obese populations and animal studies.

OBJECTIVE

The purpose of this review is to understand the global research trends and major research hotspots on obesity and gut flora from 2012-2022.

METHODS

We searched the CNKI and WOS for articles on obesity and gut flora-related research from 2012-2022. The literature was analyzed for annual postings, authors, institutions, countries, and keyword visualization using CiteSpace 6.1.R2 and VOSviewer 1.6.18.

RESULTS

841 articles in Chinese and 3459 articles in English that met the requirements were finally included. It was found that the number of published Chinese and English literature showed an overall increasing trend from 2012 to 2022, and the number of published articles increased significantly after 2016. In the Web of Science core collection database, the year 2022 was the most published year, accounting for 19.75% of the total number of articles in English.
The Web of Science Core Collection database shows that a total of 97 countries, 3997 institutions and 19880 authors are involved in this field of research. The largest number of publications in the United States is 753; the institution with the largest number of publications is Harvard Med Sch with 110 publications; the author with the largest number of publications is Cani patrice d with 58 articles.

CONCLUSIONS

From 2012-2022, an increasing number of researchers have analyzed and explored the relationship between obesity and intestinal flora. The Harvard Med Sch and Inserm institutions in the United States are the leading institutions in the field of research related to obesity and intestinal flora, and the main hot spots of Chinese and foreign research are probiotics, acupuncture to regulate intestinal flora, tight junction proteins, and tea drinks. Intestinal flora is a key research direction for improving and treating obesity, and will remain a research hotspot in the future.
The AHP analysis of Vocational Teachers’ NCS communication competencies
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Min Jeong , Park Young Min
Published: June 2023

This study is proposed to analyze an priority of educational needs of NCS communicative competence using AHP analysis. For this purpose, it conducted a questionnaire survey of 88 vocational teachers. Among the subjects, it analyzed the responses with a consistency ratio of 0.1 or less. First, ‘writing ability’ was derived as the most important ability among sub-abilities. Second, the result of priorities for each educational element of sub-abilities are as follow: ‘Confirmation and acquisition of document information’, ‘Confirmation and organization of written document information’, ‘Listening to voice information and media information’, ‘Organization information suited to purpose and situation’ were the most important educational contents elements of sub-abilities respectively. The results of this study can be used as basic data for constituting vocational education contents in the future.Since then, it has been necessary to establish a foundation for creating an educational environment that can improve students' ability to adapt to a changing career world through a wide range of research on subjects in various vocational education fields and levels.
Methods To this end, a problem-oriented learning (PBL)-based artificial intelligence teaching and learning model was designed through consideration of previous studies, and a total of 16 problem-oriented learning (PBL)-based elementary machine learning education programs were developed. Software and artificial intelligence education experts were reviewed for the developed program, and the developed education program was applied to 30 students in 1 class in 5th grade of M Elementary School in Busan. The effectiveness of problem-solving ability improvement of problem-based learning-based machine learning education programs was analyzed by analyzing the program-applied pre- and post-test papers through the corresponding sample t-test of SPSS Statistics.
Results The average value increased in all areas of problem-solving ability recognition, information collection, analysis, diffusion thinking, decision-making, planning, execution and risk-taking, evaluation, and feedback, and significant differences were also found in the significance level standards. As a result of analyzing the survey and interviews of students after the application of the education program, it was found that AI education was necessary, interested, and useful, and helped improve creativity and thinking skills, and had a positive effect on career choices related to AI.
Conclusions It was confirmed that the PBL-based elementary machine learning education program has a positive effect on problem-solving skills and artificial intelligence education for fifth graders, and it is expected to be used as a reference for follow-up studies of artificial intelligence education programs considering various grades, school forms, and convergence with subjects.
Desafios e perspectivas relacionados à ampliação do acesso da pessoa com deficiência à atenção básica
Authors: Macedo Mariana Silva , Almeida Milena Maria Cordeiro de , Arce Vladimir Andrei Rodrigues
Published: June 2023

A Rede de Cuidados à Pessoa com Deficiência, instituída em 2012, estabelece a atenção básica à saúde como elemento central para a garantia da integralidade e do acesso dessa população a serviços e ações em saúde, especialmente pela sua potencialidade enquanto coordenadora do cuidado. Os desafios para a efetivação da rede e consequente garantia do direito e acesso à saúde ainda persistem devido àdesarticulação dos serviços que a integram e à fragmentação das práticas de cuidado. Portanto, este ensaio tem como objetivo discutir alguns desafios e perspectivas relacionados à ampliação do acesso da pessoa com deficiência à atenção básica, de forma a fortalecer sua posição estratégica na rede. Superar as barreiras de acesso e garantia à saúde envolve refletir sobre novas estratégias, mas principalmente reconhecer aquelas já desenvolvidas e comprovadas – a exemplo do acolhimento e do apoio matricial –, sem ignorar o contexto sociopolítico que ainda convoca à superação do recente processo de perda de direitos sociais, de desmonte de políticas educacionais, de inclusão e de saúde.
Análise SWOT no setor de vigilância epidemiológica do município de Teresópolis (RJ): relato de experiência realizada pelo PET-Saúde
Authors: Aprigio Danielle , Pittzer Nathalia , Mendes Lívia , Rebello Eduardo , Binenbojm Raphael , Ferreira Maria Clara
Published: June 2023

Frente ao trabalho administrativo do sistema de saúde pública pautado em métodos tradicionais, torna-se necessário a implementação de estratégias facilitadoras para o planejamento das ações em saúde. O diagnóstico situacional (DS) e a análise SWOT auxiliam no ordenamento do pensamento e na implementação de ações efetivas, assim minimizando os desafios que perpassam o campo de atuação. O objetivo deste estudo foi realizar um diagnóstico situacional do Serviço de Vigilância Epidemiológica do município de Teresópolis (RJ). Trata-se de um relato de experiência de estudantes e profissionais da saúde pertencentes ao Programa de Educação pelo Trabalho para Saúde (PET-Saúde) e inseridos no cenário da vigilância epidemiológica local. Para suporte teórico, realizou-se uma busca nas bases PubMed, Scholar Google e SciELO. Forças, fraquezas, oportunidades e ameaças foram observadas a partir do DS realizado, tanto de fatores referentes ao ambiente interno como de fatores externos, possibilitando recomendações para melhor atuação e avanço organizacional. A vivência no território viabilizou o planejamento de estratégias que, além de serem empregadas na divisão de vigilância epidemiológica, abrangessem os serviços de saúde externos, assim alcançando as fragilidades laborais e garantindo atitudes resolutas para o serviço de epidemiologia do munícipio. O PET-Saúde mostrou-se uma grande oportunidade para o pensar e agir em saúde. A partir da percepção dos estudantes e profissionais envolvidos, ações foram ponderadas tanto para os fatores intrínsecos, que podem ser executadas de maneira direta pela equipe, quanto para os fatores extrínsecos, que demandam medidas indiretas para serem resolvidas, sendo revertidas em ganho para a população.
A description of the pragmatic function of mas and aí in Brazilian Portuguese: analysis on the functional equivalents of German Modal Particles
Authors: Aquino Marceli
Published: June 2023

Este artigo apresenta uma descrição da função modal de mas e aí no português brasileiro. Com uma abordagem translinguística, propõe-se uma função pragmática desses itens, que podem ser vistos como equivalentes às Partículas Modais (PMs) de língua alemã (aber e doch), isto é, com função de ancorar o enunciado em um cenário dialógico assumido (DIEWALD et al. 2017). Exemplos de uma amostra em língua portuguesa (respostas a um questionário online) foram analisados ​​dentro do esquema semântico de 3 formatos (DIEWALD; FISCHER, 1998) e, em um segundo momento, pelo Formato Descritivo esquemático (DIEWALD et al. 2017). Logo, esta proposta é original e inédita, visto que, além de analisar, sob uma perspectiva funcional, as PMs do Português Brasileiro, propõe, com uma abordagem translinguística, uma função pragmática de tais itens, de modo que podem ser vistos como equivalente às PMs de língua alemã. Os resultados indicam que é possível descrever funções pragmáticas e características formais para estas palavras no português, ressaltando a importância de tal descrição para a adequação da classificação gramatical desses elementos modais em outros idiomas além do alemão, bem como contribuir para o ensino e aprendizagem de tais fenômenos linguísticos em contextos plurilíngues.
A new model for cost estimation construction project using Hybrid importance regression ensemble method
Authors: Alkhuadhan Ali , Naimi Sepanta
Published: June 2023

Cost estimating entails gathering and evaluating historical data, as well as using quantitative models, methodologies, tools, and databases to forecast the cost of a program in the future. At the early stages of the building design process, the cost is considered one of the most important elements in making decisions. During the design phase of a project, cost estimating is quite essential. To compelet a construction project successfully, it is critical to design a usable model and method for cost estimation in construction projects. For the above reason, this study has developed a hybrid method to conduct an accurate cost estimation in construction projects in Iraq. This study also conducted a rigorous survey to find five main influential factors with thirty-six sub-factors in the Iraqi market. It was evaluated through previous studies, questionnaires, and surveys of twenty projects to build a matrix factors database for construction projects. This work gathered the construction cost factors from relevant research and expert views. In the second step, the researcher ranked the factors within the Importance Regression Ensemble Method then the K-Nearest Neighbor Method was applied to specify the effect of the near-effective factors on the cost. The outcome of this study will be helpful to construction professionals in estimating a construction project effectively.
Co-creativity in Living Labs: fostering creativity in co-creation processes to transform food systems
Authors: Massari Sonia , Galli Francesca , Mattioni Dalia , Chiffoleau Yuna
Published: June 2023

In this article, the authors aim to reflect on the relationship between collaborative creation and creativity ('co-creativity') within Living Lab (LL) research and innovation in the domain of agri-food systems.While the value of LL is often perceived to be the collaboration among its participants, there is a need to capture and measure the process of co-creation.Co-creativity is indicated by the literature to be a necessary research and collaborative component of social change, as well as for promoting a transformative sustainability agenda.This article uses empirical and primary data collected in the context of the DIVINFOOD project to show the extent to which researchers actively promote, manage and respond to the effects of collaborative creativity within their research. Collaborative creativity is an indispensable component of the co-creation process because it supports collaborative learning. The authors conclude that measuring co-creativity could be an interesting indicator to monitor the development of LLs over time.
EFFECT OF LIVE STREAMING E-COMMERCE IN BUILDING CUSTOMER TRUST AND CUSTOMER ENGAGEMENT (STUDY ON TOKOPEDIA CONSUMERS)
Authors: Yudha Jodhi Kartha , Komaladewi Rita , Yudha R. Thomas Budhyawan
Published: June 2023

In recent years, e-commerce in Indonesia is growing rapidly which makes the level of competition between e-commerce is also high and has resulted in the closure of several e-commerce because they are unable to compete. It can be said that live streaming is one of the innovations as a marketing strategy for new e-commerce. To avoid suspicions of different product characteristics photos, fake shops, fraudulent sellers and others and to increase customer trust, Tokopedia Play created a live shopping experience feature. And can increase customer engagement which ultimately consumers buy and revisit. This study aims to examine the effect of live streaming, customer trust, and customer engagement in making online purchases on Tokopedia e-commerce. The independent variable in this study is live streaming. The dependent variable is customer engagement. And the intervening variable is customer trust. Respondents in this study were people who had shopped online through live streaming on Tokopedia Play. This study uses quantitative research methods and PLS analysis. Using a minimum of 105 respondents. The results of the study show that: (1) Live streaming has a positive and significant effect on customer trust. (2) Customer trust has a positive and significant effect on customer engagement. (3) The effect of live streaming on customer trust and on customer engagement is significant and positive.
PERAN SUPORTER SEPAKBOLA SEBAGAI KELOMPOK PENEKAN
Authors: Djuyandi Yusa , Siregar Muhammad Musthofa , Muradi Muradi
Published: June 2023

Bicara tentang sepakbola Indonesia adalah bicara tentang harga diri, kebanggaan, dan identitas para suporternya yang diwakilkan oleh klub kesayangannya. Hal tersebut tentu membuat kompetisi sepakbola semakin ramai dan aroma pesaingannya semakin ketat karna tekanan dari kelompok suporter tersebut. Riset ini menggunakan analisis deskriptif dengan studi kasus kelompok suporter The Jakmania dalam menyikapi performa buruk klub Persija Jakarta. Riset ini menyimpulkan bahwa kelompok suporter The Jakmania cukup mampu memainkan perannya sebagai kelompok penekan dengan cara yang cukup elegant seperti kritik melalui sosial media, mengadakan briefing untuk menentukan sikap yang secara tidak langsung menghimpun opini publik dan pada akhirnya mampu memperngaruhi manajemen klub Persija Jakarta dalam mengambil keputusan
Pembelajaran pemahaman konsep bilangan bulat pada kelas III Sekolah Dasar dengan menggunakan alat peraga kancing
Authors: Wahyuningsih Rini Purwani , Kelana Jajang Bayu
Published: June 2023

This study aims to determine the scenario and implementation, teacher and student responses, the difficulties of teachers and students in implementing integer learning using button props. The research subjects were teachers and students of class III SD Cerdas Muthahhari, totaling 20 students. The form of this research is descriptive qualitative research. The research procedure includes the stages: preparation, implementation, and evaluation. The research process at the implementation stage includes the implementation of a pre-test to measure the understanding of mathematical concepts before being treated, the treatment stage is to carry out learning using button props, the next stage is an evaluation by carrying out a post-test to see the understanding of mathematical concepts after being treated. The results showed that there was a better understanding of concepts and student activeness in the learning process. This proves that learning integer arithmetic operations using buttons improves students' understanding of mathematical concepts.
Rigorous 3-D modeling of the ground electric field in Fennoscandia during the Halloween geomagnetic storm
Authors: Marshalko Elena , Kruglyakov Mikhail , Kuvshinov Alexey , Viljanen Ari
Published: June 2023

In this study, we perform rigorous three-dimensional (3-D) ground
electric field (GEF) modeling in Fennoscandia for three days of the
Halloween geomagnetic storm (29-31 October 2003) using magnetic field
data from the IMAGE magnetometer network and a 3-D conductivity model of
the region. To explore the influence of the inducing source model on 3-D
GEF simulations, we consider three different approaches to source
approximation. Within the first two approaches, the source varies
laterally, whereas in the third method, the GEF is calculated by
implementing the time-domain realization of the magnetotelluric
intersite impedance method. We then compare GEF-based geomagnetically
induced current (GIC) with observations at the Mäntsälä natural gas
pipeline recording point. We conclude that a high correlation between
modeled and recorded GIC is observed for all considered approaches. The
highest correlation is achieved when performing a 3-D GEF simulation
using a “conductivity-based” laterally nonuniform inducing source. Our
results also highlight the strong dependence of the GEF on the earth’s
conductivity distribution.
Antibacterial Effect Of Bacillus species Biomolecules (Metabolites, Silver Nanoparticles, And Functionalized Silver Nanoparticles) Against Multi-Drug Resistance Listeria species
Authors:   Industrial Microbiology and Biotechnology Unit, Department of Microbiology, Faculty of Science, University of Ibadan, Private Bag 5116, Ibadan 200284, Oyo State, Nigeria., Adeniran O.A. , Sanusi, J.F. , Adebami G.E. , Adebayo-Tayo B.C.
Published: June 2023

The study investigated the anti-listeria activity of Bacillus subtilis (BsaM), Bacillus licheniformis (BlbM) and Bacillus megaterium (BmcM) against seven Listeria species. Metabolites from Bacillus spp. were used for silver nanoparticles (BsaSNPs, BlbSNPs, and BmcSNPs) biosynthesis. The Silver Nanoparticles (SNPs) characterization was done using visual observation, UV-Visible Spectrophotometric, FTIR, SEM, and EDXRF. The anti-listeria synergistic potential of the biosynthesized SNPs and functionalized SNPs against Multidrug resistance (MDR) Listeria strains was evaluated. The BsaM, BlbM, and BmcM had a varied anti- listeria effect against the Listeria spp. 71.43, 100, and 5.71 % of the Listeria spp. were susceptible to the BsaM, BlbM, and BmcM metabolites respectively. The metabolite bio-actively reduced AgNO3 for BsaSNPs, BlbSNPs, and BmcSNPs production. Surface Plasma Resonance (SPR) peaks of 600 nm, 400 and 600 nm, and 600 nm were recorded for BsaSNPs, BlbSNPs, and BmcSNPs. The shape of the SNPs were aggregated, rods, and crystalline. The functional groups present in the nanoparticles were carboxylic acid, amino acid, alcohol, esters, and aldehydes had the highest intensity. BsaSNPs, BlbSNPs, and BmcSNPs had the highest anti-listeria potential of 20.0, 16.0 and 22.0 mm against Listeria innocua LA22A and Listeria ivanovii LA6. Functionalized BsaSNPs, BlbSNPs, and BmcSNPs had the highest anti-listeria activity compared to the metabolites and commercial antibiotics. Ciprofloxacin-BsaSNPs, Erythromycin-FBlbSNPs, and Erythromycin-FBmcSNPS had the highest antagonistic activity (28, 26, and 27 mm) against Listeria ivanovii LA6 respectively. The Bacillus strains’ metabolites, the SNPs, and functionalized SNPs exhibit antimicrobial activities against Multidrug resistance Listeria species. Functionalization improved the anti-listerial ability of the antibiotics. Keywords: Bacillus species, Anti-listeria activity, SNPs, MDR Listeria species, Functionalization
103-OR: LX9211, an Orally-Administered, Non-opioid, AAK1 Inhibitor for Painful Diabetic Peripheral Neuropathy—Results from a Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study
Authors: BUSUI RODICA , PATEL ANAND , SANG CHRISTINE N. , GRANOWITZ CRAIG B. , BANKS PHILLIP L. , PIERCE PHILLIP , SUN FRANKLIN W. , GOPINATHAN SUMA
Published: June 2023

Diabetic peripheral neuropathy (DPN) is a common complication in individuals with diabetes with high morbidity and mortality. Painful DPN impacts quality of life and is very challenging to treat. The efficacy and safety of LX9211, a potent, non-opioid inhibitor of a novel target, AP2-associated protein kinase 1 (AAK1) was evaluated in a Phase 2 randomized, double-blind, placebo-controlled, parallel-group, multicenter clinical study (RELIEF-DPN 1). The baseline characteristics [mean (SD)] of 319 adults were age 62.2 (9.94) years, A1C 7.7 (1.28) %, BMI 32.07 (4.45) kg/m2, and average daily pain score (ADPS) after placebo run-in period 6.55 (1.089). Patients were randomized to either placebo, LX9211 100 mg/10 mg (100 mg Day 1, 10 mg thereafter-Low Dose arm), or LX9211 200 mg/20 mg (200 mg Day 1, 20 mg thereafter-High Dose arm) for 6 weeks followed by 5-week safety follow-up period. At Week 6, LX9211 was associated with significant improvement in Neuropathic Pain Symptom Inventory (NPSI) total score (Low Dose: -5.18, p=0.064; High Dose: -7.22, p=0.008), burning pain (Low Dose: -1.40; p<0.001; High Dose: -0.89, p=0.017), pain interference on sleep (Low Dose: -0.96, p=0.005; High Dose: -1.04, p=0.002) and Patient Global Impression of Change score (Low Dose: -0.35, p=0.031; High Dose: -0.15, p=0.351) compared to placebo while achieving the primary endpoint (change from placebo in ADPS) in the low dose arm. LX9211 was safe (no treatment-related SAEs or deaths) and did not affect key cardiometabolic parameters (body weight, blood pressure, glucose control, cholesterol levels). RELIEF-DPN 1 demonstrated significant improvements in validated neuropathic pain instruments and in other patient reported outcomes suggesting that LX9211 is a promising, opioid independent new avenue to treat people with painful DPN. Confirmation of these positive results are planned in future Phase 3 trials.

Disclosure

R.Busui: Board Member; American Diabetes Association, Consultant; Averitas Pharma, Inc., Lexicon Pharmaceuticals, Inc., Nevro Corp., Novo Nordisk, Roche Diagnostics, Procter & Gamble, Research Support; Novo Nordisk, Medtronic, National Institutes of Health. A.Patel: Other Relationship; Lexicon Pharmaceuticals, Inc. C.N.Sang: Consultant; Arena Pharmaceuticals, Inc., Covance, SOLVD, Other Relationship; Kolon, Research Support; AbbVie Inc., Merck & Co., Inc., Tonix, Lexicon Pharmaceuticals, Inc., Vivozon, Helixmith. C.B.Granowitz: None. P.L.Banks: Employee; Lexicon Pharmaceuticals, Inc. P.Pierce: Employee; Lexicon Pharmaceuticals, Inc. F.W.Sun: Employee; Lexicon Pharmaceuticals, Inc. S.Gopinathan: Employee; Lexicon Pharmaceuticals, Inc.

Funding

Lexicon Pharmaceuticals, Inc.
1044-P: Advancing Quality Improvement Culture among 27 Pediatric and Adult Diabetes Centers
Authors: MUNGMODE ANN , ODUGBESAN ORI , ELISHA VICTOR , STEENKAMP DEVIN W. , KAMBOJ MANMOHAN K. , DESALVO DANIEL , SONABEND RONA Y. , NEYMAN ANNA , MATHIAS PRIYANKA M. , CHAO LILY , ILKOWITZ JENIECE , EBEKOZIEN OSAGIE , COLLABORATIVE T1DX-QI
Published: June 2023

Background: The T1D Exchange Quality Improvement Collaborative (T1DX-QI) is a learning health system of over fifty endocrinology centers working to improve diabetes outcomes through Quality Improvement (QI). Centers join T1DX-QI with varying levels of QI culture and are assigned a QI Coach to support practice transformation. This study summarizes the results of 27 endocrinology centers involved in the T1DX-QI for over 12 months.

Method: Centers completed a 20-question self-assessment survey to measure QI culture over time in four evidence-based areas: QI Team Structure (team roles); QI Foundation (data collection and training); QI Capacity (use of QI tools); and QI Success (scaling up small tests). Data was collected in 2021 and 2022 for the same centers. The overall difference in QI Capacity was calculated using a Chi-Square test.

Results: Overall, QI Culture increased from 67% to 75% from 2021 to 2022 (p-value = 0.005). Figure 1 demonstrates that improvements were seen in three of the four evidence-based areas for both pediatric and adult centers in this time.

Conclusion: Even with as little as one year of involvement with the T1DX-QI, centers experience an improvement in their QI Capacity.

Disclosure

A.Mungmode: None. L.Chao: None. J.Ilkowitz: None. O.Ebekozien: Advisory Panel; Medtronic, Research Support; Eli Lilly and Company, Dexcom, Inc. T1dx-qi collaborative: n/a. O.Odugbesan: None. V.Elisha: None. D.W.Steenkamp: Research Support; Abbott Diabetes, Novo Nordisk. M.K.Kamboj: None. D.Desalvo: Consultant; Dexcom, Inc., Research Support; Insulet Corporation. R.Y.Sonabend: None. A.Neyman: None. P.M.Mathias: None.

Funding

The Leona M. and Harry B. Helmsley Charitable Trust
1055-P: Clinical Decision Support Systems (CDSSs) in Diabetes Management—A Scoping Review
Authors: HUANG SHAN , LIANG YUZHEN , LI JIARUI , JUN LI XUE
Published: June 2023

This scoping review aimed to summarize the application scenarios, effectiveness and safety of CDSS in diabetes management. PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, VIP, and conference databases were searched from 1985 to 2022. There were 11,145 studies identified, and 72 articles and 8 abstracts were included, involving 137,710 subjects. Most CDSSs (77%) were knowledge-based, while the non-knowledge-based systems have been increasing in recent years. CDSS was mainly utilized in treatment recommendations (Table 1). Most CDSSs significantly improved outcomes (Table 2) without increase of hypoglycemia risk. The results demonstrated the value of CDSS as a reliable assistant in diabetes management especially in primary care with limited resources, and advanced software is needed to improve CDSS functionalities.

Disclosure

S.Huang: None. Y.Liang: None. J.Li: None. X.Li: None.

Funding

Beijing Medical Award Foundation (2019-1585)