bluuebunny/crossref_metadata_2025 huggingface dataset:
Extreme precipitation and temperature indices under future climate change in central Asia based on CORDEX-CORE
Authors: Rai Praveen , Bangelesa Freddy , Abel Daniel , Ziegler Katrin , Huang Jingshui , Schaffhauser Timo , Pollinger Felix , Disse Markus , Paeth Heiko
Published: May 2024

The present study analyzes the projected changes of extreme climate indices over Central Asia using regional climate model (RCM) simulations from the Coordinated Regional Climate Downscaling Experiment (CORDEX) - Coordinated Output for Regional Evaluations (CORE). The extreme indices are based on precipitation and temperature and are inspected for present (1981–2005) and future periods - near- (2031–2055) and far-future (2071–2095) - to assess the long-term climate change under the representative concentration pathway RCP8.5. Projected changes are analyzed for three different model ensembles. These ensembles are based on CORDEX-Central Asia (ENS_CAS, four ensemble members) and CORDEX-East Asia (ENS_EAS, six ensemble members), and a combination of both (ENS, ten ensemble members) for our study area centered over high mountain Asia, called Central East Asia (CEAS). For precipitation indices, an increase of consecutive dry days (CDD) in ENS_EAS and a slight to moderate decrease in northern parts in ENS_CAS during near-future is observed. Consecutive wet days (CWD), very heavy precipitation events (R20mm), maximum one-day precipitation (RX1day), and very wet days (R95p) are projected to increase in most areas. All indices show a further intensification towards the end of the century over large parts of the domain, e.g., + 7.8% / +5.6 days for CDD, + 96.6% / +0.26 days for R20mm, and + 19.7% for RX1day as median of ENS over CEAS. For temperature indices, the ensembles project a strong increase over the high mountain regions and southern parts for consecutive summer days (CSU, + 108.5% / +38.3 days), heat wave duration index (HWDI, + 1379.1% / +91.37 days), and the percentage of very hot days (TX90p, + 391.1% / +34.54 days). Accordingly, the number of consecutive frost days (CFD, -43.7% / -25.2 days) and the percentage of very cold days (TX10p, -83.4% / -8.13 days) are projected to decrease. The first-time usage of CORDEX-CORE and the larger ensemble size by considering simulations from overlapping domains increase the robustness of the findings from earlier studies. However, some discrepancies in the projected changes prevail among the different RCMs being part of the two CORDEX-domains and in specific landscapes like complex mountainous or lake areas. These uncertainties may be tackled by further model development with improved land-surface processes and potentially higher spatial resolution.
Are cleaner energy and financial technologies needed? Contagion and causality evidence between global fintech markets, energy consumption, and environmental pollution
Authors: Ersin Özgür Ömer , Bildirici Melike E.
Published: May 2024

Financial technology (FinTech) depends on high amounts of energy with an upward trend, possibly affecting emissions due to energy consumption (EC). The study investigates tail dependence, contagion, and nonlinear between FinTech, EC, and carbon dioxide emissions (CO2e) with MS-GARCH-copula and MS-GARCH-copula-causality with a daily sample covering 02 Jan 2012–28 December 2022. The method is a generalized version of single-regime GARCH-copula and causality tests to Markov-switching. Empirical results indicated that FinTech, EC, and CO2e series follow nonlinear processes in addition to unit roots as determined by BDS nonlinearity tests and a set of linear and nonlinear unit root tests. Further, for all series, heteroskedasticity and nonlinear forms of heteroskedasticity cannot be rejected by ARCH–LM and White heteroskedasticity tests, leading to the estimation of the series and their joint dynamics by MS-GARCH-copula and a new MS-GARCH-copula based nonlinear Granger-causality test, the RSGCC test, under two distinct regimes characterized with the low and high volatility for extreme tails of data. Positivity and significance of copula parameters under both regimes indicate a high degree of positive but asymmetric tail dependence and contagion between FinTech & EC, in addition to contagion between FinTech & CO2e and EC & CO2e. RSGCC results determine unidirectional causalities from EC to CO2e and from FinTech to CO2e, coupled with bidirectional causality between FinTech and EC, which enhance the dynamics due to feedback effects. The findings of this paper are of importance for two central Sustainable Development Goals. Results could also be used to bring the FinTech markets and EC to the attention of policymakers, researchers, and eco-friendliness-focused portfolio managers.

Graphical Abstract
Which support is provided in which country? Patterns among older adults in Europe
Authors: Furfaro Emanuela , Pelle Elvira , Rivellini Giulia , Zaccarin Susanna
Published: May 2024

This paper proposes comparative research on support provided outside the household by older adults in Europe. In studying social support, the network perspective is widely used, investigating, in particular, the ego-centered support networks of individuals. The analysis is based on data from Wave 7 of the Survey of Health Ageing and Retirement in Europe (SHARE). It examines the characteristics of ego-support networks of individuals aged 65 and over in 12 European countries, which are grouped into a novel welfare regime typology. Through Multiple Correspondence Analysis, we jointly looked into the categorical variables describing the recipients (alters) of the support provided by older adults and the welfare regime classification. As a main result, countries grouped in “High degree of familialism by default” category specialized in supporting family-related alters, particularly with childcare or personal care. In contrast, the elders in countries belonging to “High degree of de-familialisation” typology provided a more varied but less demanding support, to non-relatives alters and less oriented to care. The analyses show that the SHARE provides a solid opportunity to face the topic.
Generating the Moral Agency to Report Peers’ Counterproductive Work Behavior in Normal and Extreme Contexts: The Generative Roles of Ethical Leadership, Moral Potency, and Psychological Safety
Authors: Sumanth John J. , Hannah Sean T. , Herbst Kenneth C. , Thompson Ronald L.
Published: May 2024

Reporting peers’ counterproductive work behaviors (CWBs) is important for maintaining an ethical organization, but is a significant and potentially risky action. In Bandura’s Theory of Moral Thought and Action (Bandura, 1991) he states that such acts require significant moral agency, which is generated when an individual possesses adequate moral self-regulatory capacities to address the issue and is in a context that activates and reinforces those capacities. Guided by this theory, we assess moral potency (i.e., moral courage, moral efficacy, and moral ownership) as key capacities predicting peer reporting intentions and assess three contextual factors influencing the generation and effects of moral potency: whether a potential informant (1) works for an ethical leader, (2) is embedded in a psychologically safe climate promoting interpersonal risk-taking, and (3) operates in a more normal or extreme context. We assess the proposed model across three field studies entailing both normal and extreme (i.e., firefighting units) contexts. Results show that ethical leaders raise employees’ moral potency, promoting greater willingness to report their peers’ CWBs. In normal work contexts, psychological safety positively moderated both the relationship between ethical leadership and moral potency and between moral potency and peer reporting intentions. However, psychological safety had the opposite effects in more extreme work contexts. Whereas psychological safety strengthens the positive association between moral potency and peer reporting intentions in normal work contexts, in contexts where individuals are more frequently exposed to extreme events, psychological safety weakens this relationship, thus highlighting the unforeseen downsides of psychological safety in extreme contexts.
Design of Concrete Mock-Ups with Complex Defect Scenarios Using Numerical Simulations
Authors: Dethof Fabian , Keßler Sylvia
Published: May 2024

The major objective when applying non-destructive testing (NDT) in civil engineering is the detection of defects such as honeycombs. Defects can impair the service life of structures and could lead in the worst case to fatal failures. All structures such as bridges, tunnels, locks etc. are unique objects with variation in geometry, dimensions, materials, environmental condition, load scenarios etc. Thus, the interpretation of NDT data is challenging and the validation of the NDT method, the training of inspectors and the reliability analysis of NDT rely on mock-ups with known defect situations mimicking the type of defect as realistic as possible. The considered defect sizes inside the mock-ups should cover the transition zone between detectable and non-detectable to properly evaluate the capability of the inspection system. However, knowledge about the limits of an inspection system is mostly non-existent. To overcome this limitation, this study applies realistic numerical simulations for ultrasonic testing in reinforced concrete performed with the elastodynamic finite integration technique (EFIT) to identify this transition zone. First, the study shows the development and the validation of a numerical representation of concrete considering the implementation of a qualitatively realistic noise level. Additionally, the accurate representation of the sources during ultrasonic testing is confirmed by an investigation of the radiation characteristic for dry point contact ultrasonic transducers. The simulation outcome enabled the design of a mock-up, which explores the detection limits for honeycombs during ultrasonic testing under different boundary conditions. A case study demonstrates the applicability of the design scheme based on numerical simulation. In the real specimen designed with the assistance of numerical simulations, $$68\mathrm{\%}$$

68
%

of the implemented defects are detectable, proving the effectiveness of the design methodology.
“Particle therapy - future for the Baltic states?” – synthesis of the expert workshop report
Authors: Paļskis Kristaps , Korobeinikova Erika , Bogorada-Saukuma Dace , Camarda Anna Maria , Taylor Rebecca , Benedetto Elena , Mamis Edgars , Radziņa Maija , Ērglis Andrejs , Adliene Diana , Dosanjh Manjit , Vretenar Maurizio , Torims Toms
Published: May 2024

Background

Baltic States remains one of the few regions in the Europe without a dedicated particle therapy center. An initiative since 2021 has been started by CERN Baltic Group on a novel particle therapy center development in the region in partnership with CERN NIMMS collaboration. With a conceptual design idea in early 2022 and stakeholder engagement activities in late 2022 - next step forward was necessary for the initiative for a more in-depth analysis.

Methods

A dedicated workshop “Particle therapy - future for the Baltic States? State-of-play, synergies and challenges” was held. The workshop was attended by medical community from the Baltics, as well as CERN technical experts and particle therapy practicing clinicians, with scientific programme split in 5 main areas of investigation.

Results

Current cancer epidemiology statistics and RT technological possibilities in the region were analyzed, with first estimates of eligible number of patients calculated. Technological development level of the proposed accelerator complex was discussed, as well the clinical needs and synnergy possibilities with the nuclear medicine field.

Conclusions

The current state and calculated first estimates presented here have shown a promising starting point, which prompts even further in-depth work – a feasibility study for development of a novel particle therapy center in the Baltic States.
How Public Support for Innovation Affect Entrepreneurial Orientation of Mexican Companies: The Moderating Effect of Being a Family Business
Authors: Tlacuilo-Parra Yenira , López-Fernández María Concepción , Hernández-Linares Remedios , García-Piqueres Gema
Published: May 2024

We study the relationships between the input and network additionalities prompted by public support for innovation and entrepreneurial orientation and whether being a family business moderates these relationships. The results, based on a dataset of 115 Mexican firms, show that the changes generated by public support for innovation programmes encourage entrepreneurial orientation. Additionally, family firms have a differential ability to transform input and network additionalities into entrepreneurial orientation. This study contributes theoretically and practically by highlighting the positive effects of research and development support programmes on a firm’s entrepreneurial orientation. It also points out the need to consider family status when designing public policies, since our results reveal that family and non-family firms are not equally efficient in transforming resources into entrepreneurial orientation and that family firms that drive networking through the rules of the subsidy do not trigger the expected potential benefits.
Consensus commentary and position of the Italian Society of Nephrology on KDIGO controversies conference on novel anemia therapies in chronic kidney disease
Authors: Locatelli Francesco , Del Vecchio Lucia , Esposito Ciro , Gesualdo Loreto , Grandaliano Giuseppe , Ravera Maura ,   on behalf of the Collaborative Study Group on the Conservative Treatment of CKD of the Italian Society of Nephrology, Minutolo Roberto
Published: May 2024

Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are new drugs developed for the treatment of anemia associated with chronic kidney disease (CKD). This class of drugs stimulates endogenous erythropoietin production and, at the same time, improves iron absorption and mobilization of iron stores (less evident with daprodustat, vadadustat and enarodustat). Several studies have been published in the last few years showing that these agents are not inferior to standard therapy in correcting anemia associated with CKD. The efficacy of HIF-PHIs is coupled with a safety profile comparable to that of standard erythropoiesis stimulating agent (ESA) treatment. However, studies with HIF-PHIs were not long enough to definitively exclude the impact of new drugs on adverse events, such as cancer, death and possibly cardiovascular events, that usually occur after a long follow-up period. Kidney Disease: Improving Global Outcomes (KDIGO) recently reported the conclusions of the Controversies Conference on HIF-PHIs held in 2021. The goal of the present position paper endorsed by the Italian Society of Nephrology is to better adapt the conclusions of the latest KDIGO Conference on HIF-PHIs to the Italian context by reviewing the efficacy and safety of HIF-PHIs as well as their use in subpopulations of interest as emerged from more recent publications not discussed during the KDIGO Conference.

Graphical abstract
Designing Mathematical Programming Problems
Authors: Munthe Morten , Naalsund Margrethe
Published: May 2024

The growing use of programming in mathematics classrooms presents a challenge linked to implementation in general and task design in particular. This article presents design ideas for mathematical problems incorporating programming in which the focus remains mainly on learning mathematics and less on learning programming. The article starts by reviewing the theoretical background for technology implementation and design, and then presents the methodology for the design, before exploring and discussing the design ideas with an in-depth example. Building on the idea of adidactical situations from the theory of didactical situations, the design illustrates a possible way of implementing programming in the mathematics classroom to facilitate mathematical learning.
Cost Analysis and Prediction of Railroad Level Crossing Accidents for Indian Railways
Authors: Chhotu Anil Kumar , Suman Sanjeev Kumar
Published: May 2024

With the tremendous increase in the number of vehicles, the dense traffic created can lead to accidents and fatalities. In a traffic system, the costs for accidents are immeasurable. Numerous studies have been carried out to predict the cost of fatal accidents but have provided the actual values. Therefore, in this study, a monkey-based modular neural system (MbMNS) is developed to identify accident cost. The accident cases and cost data were collected and preprocessed to remove the noise, and the required features were extracted using the spider monkey function. Based on the extracted features, the accidents and the costs were identified. For rail engineering, this will support evaluating the number of railroad crossing accidents with different time intervals. The impact of every accident was also measured with different cost analysis constraints, including insurance, medical, and legal and administrative costs. Therefore, the present study contributes to the field by collecting and organizing the present railroad level crossing accident data from crossing inventory dashboards. Then, the introduction of a novel MbMNS for the cost analysis is the primary contribution of this study to further enrich the railroad level crossing protection system. The third contribution is the tuning of the prediction layer of a modular neural network to the desired level to achieve the highest predictive exactness score. Hence, the designed MbMNS was tested in the Python environment, and the results were validated with regard to recall, accuracy, F-measure, precision, and error values; a comparative analysis was also conducted to confirm the improvement. The novel MbMNS recorded high accuracy of 96.29% for accident and cost analysis, which is better than that reported for other traditional methods.
Learning to compose diversified prompts for image emotion classification
Authors: Deng Sinuo , Wu Lifang , Shi Ge , Xing Lehao , Jian Meng , Xiang Ye , Dong Ruihai
Published: May 2024

Image emotion classification (IEC) aims to extract the abstract emotions evoked in images. Recently, language-supervised methods such as contrastive language-image pretraining (CLIP) have demonstrated superior performance in image understanding. However, the underexplored task of IEC presents three major challenges: a tremendous training objective gap between pretraining and IEC, shared suboptimal prompts, and invariant prompts for all instances. In this study, we propose a general framework that effectively exploits the language-supervised CLIP method for the IEC task. First, a prompt-tuning method that mimics the pretraining objective of CLIP is introduced, to exploit the rich image and text semantics associated with CLIP. Subsequently, instance-specific prompts are automatically composed, conditioning them on the categories and image content of instances, diversifying the prompts, and thus avoiding suboptimal problems. Evaluations on six widely used affective datasets show that the proposed method significantly outperforms state-of-the-art methods (up to 9.29% accuracy gain on the EmotionROI dataset) on IEC tasks with only a few trained parameters. The code is publicly available at https://github.com/dsn0w/PT-DPC/for research purposes.
British Humanitarianism, Indigenous Rights, and Imperial Crises: Assessing the Membership Base of the Aborigines’ Protection Society, 1840–73
Authors: Reid Darren
Published: May 2024

A confluence of societal changes, particularly hardening racial attitudes following the Indian Mutiny in 1857 and the Morant Bay Rebellion in 1865, resulted in widescale disillusionment with imperial humanitarian projects in the middle decades of the nineteenth century. As this article demonstrates, however, the membership and income of the Aborigines’ Protection Society (APS) increased at precisely the moments when this disillusionment was at its sharpest. This article combines quantitative and qualitative methods to assess the nature of the Society's mid-century membership base, demonstrating that, rather than a monolithic decline, a humanitarian polarization took place in response to imperial crises that led some (largely Tories) to disillusionment and others (largely Whigs) to entrenchment. Furthermore, by attending to discursive trends within speeches at APS annual meetings as well as in private correspondence between members and the secretary of the Society, I explore how APS members explained the connection between their own lives and the treatment of distant Indigenous peoples in the colonies. Finding that British Indigenous rights activism was only seldomly expressed in terms of Indigenous peoples themselves, I show that support for the APS was most commonly related to concerns for friends and family living in the colonies, along with disquiet about the impact of colonial injustices on international competition. This enabled Indigenous rights activists to continue their efforts in the face of disillusionment with the capabilities of racialized “others.”
Microfluidic jet impacts on deep pools: transition from capillary-dominated cavity closure to gas-pressure-dominated closure at higher Weber numbers
Authors: Kroeze Thijmen B. , Fernandez Rivas David , Quetzeri-Santiago Miguel A.
Published: May 2024

Studying liquid jet impacts on a liquid pool is crucial for various engineering and environmental applications. During jet impact, the free surface of the pool deforms and a cavity is generated. Simultaneously, the free surface of the cavity extends radially outward and forms a rim. Eventually the cavity collapses by means of gas inertia and surface tension. Our numerical investigation using an axisymmetric model in Basilisk C explores cavity collapse dynamics under different impact velocities and gas densities. We validate our model against theory and experiments across a previously unexplored parameter range. Our results show two distinct regimes in the cavity collapse mechanism. By considering forces pulling along the interface, we derive scaling arguments for the time of closure and maximum radius of the cavity, based on the Weber number. For jets with uniform constant velocity from tip to tail and

$We \leqslant 150$

, the cavity closure is capillary-dominated and happens below the surface (deep seal). In contrast, for

$We \geqslant 180$

the cavity closure happens above the surface (surface seal) and is dominated by the gas entrainment and the pressure gradient that it causes. Additionally, we monitor gas velocity and pressure throughout the impact process. This analysis reveals three critical moments of maximum gas velocity: before impact, at the instant of cavity collapse and during droplet ejection following cavity collapse. Our results provide information for understanding pollutant transport during droplet impacts on large bodies of water, and other engineering applications, like additive manufacturing, lithography and needle-free injections.
Laminar separation bubble formation and bursting on a finite wing
Authors: Toppings Connor E. , Yarusevych Serhiy
Published: May 2024

The transient processes of laminar separation bubble (LSB) formation and bursting on a rectangular NACA 0018 wing are studied experimentally. A two-dimensional airfoil model is used as a baseline for the assessment of finite wing effects. The models are subjected to ramp changes in free-stream velocity causing the flow to switch between a state where an LSB forms and a state without reattachment. Lift force and particle image velocimetry measurements are used to relate the flow development to the aerodynamic loading. The lift coefficient of the airfoil exhibits substantial hysteresis, and the duration of the lift transients range from

$10$

to

$22$

convective time scales for bubble formation and

$22$

to

$30$

convective time scales for bursting. In contrast, the transient lift coefficients of the wing change gradually, with less hysteresis. The wing tip causes greater three-dimensionality in the separation bubble, whose thickness increases near the midspan where bursting is initiated. During bubble formation, the region of separated flow contracts towards the midspan. The gradual change in lift of the wing is linked to slower spanwise expansion and contraction of the separated flow region relative to the airfoil. On both models, the wavenumbers and amplitudes of disturbances in the separated shear layer rapidly change when reattachment initiates or ceases. Applying the bursting criterion of Gaster (Tech. Rep. Reports and Memoranda 3595. Aeronautical Research Council, London, 1967) to the bubble on the wing shows that bursting of the bubble at a single spanwise location is insufficient to cause complete spanwise failure of reattachment, and that the relationship between bursting parameters depends on spanwise position.
How Can Data Science Contribute to Understanding the Khipu Code?
Authors: Medrano Manuel , Khosla Ashok
Published: May 2024

In “How Can Spin, Ply, and Knot Direction Contribute to Understanding the Quipu Code?” (2005), mathematician Marcia Ascher referenced new data on 59 Andean khipus to assess the significance of their variable twists and knots. However, this aggregative, comparative impulse arose late in Ascher's khipu research; the mathematical relations she had identified among 200+ previously cataloged khipus were specified only at the level of individual specimens. This article pursues a new scale of analysis, generalizing the “Ascher relations” to recognize meaningful patterns in a 650-khipu corpus, the largest yet subjected to computational study. We find that Ascher formulae characterize at least 74% of khipus, which exhibit meaningful arrangements of internal sums. Top cords are shown to register a minority of sum relationships and are newly identified as markers of low-level, “working” khipus. We reunite two fragments of a broken khipu using arithmetic properties discovered between the strings. Finally, this analysis suggests a new khipu convention—the use of white pendant cords as boundary markers for clusters of sum cords. In their synthesis, exhaustive search, confirmatory study, mathematical rejoining, and hypothesis generation emerge as distinct contributions to khipu description, typology, and decipherment.
Ethical frameworks of informed consent in the age of pediatric precision medicine
Authors: Chen David
Published: May 2024

Precision medicine is an emergent medical paradigm that uses information technology to inform the use of targeted therapies and treatments. One of the first steps of precision medicine involves acquiring the patient’s informed consent to protect their rights to autonomous medical decision-making. In pediatrics, there exists mixed recommendations and guidelines of consent-related practices designed to safeguard pediatric patient interests while protecting their autonomy. Here, we provide a high-level, clinical primer of (1) ethical informed consent frameworks widely used in clinical practice and (2) promising modern adaptations to improve informed consent practices in pediatric precision medicine. Given the rapid scientific advances and adoption of precision medicine, we highlight the dual need to both consider the clinical implementation of consent in pediatric precision medicine workflows as well as build rapport with pediatric patients and their substitute decision-makers working alongside interdisciplinary health teams.
American Dream versus American Reality: How Information about Structural Racism Can Prompt Support for Race-Based Policies
Authors: Christiani Leah , Kelly Nathan J. , Morgan Jana
Published: May 2024

Negative racial stereotypes routinely work together with myths about American equality to undermine public support for policies that would reduce inequality. But what happens when white Americans are confronted with information about structural racial inequality, which contradicts the myth of equal opportunity? Evidence from an original survey experiment conducted among approximately 4,000 white Americans demonstrates that emphasizing the systemic origins of racial inequalities in the COVID-19 pandemic makes respondents more accepting of policies aimed at reducing racial inequalities in a variety of domains. Qualitative insights from post-treatment reflections further show that facing the reality of structural inequality disrupts blame-based narratives and generates support for policies meant to confront inequality. The findings suggest that discussing structural inequality can disrupt individualistic understandings and increase approval for policies that promote equality across multiple domains; they also illuminate why opponents of equality see discussions of structural inequality as so threatening.
Reversion to the Mean, or Their Version of the Dream? Latino Voting in an Age of Populism
Authors: FRAGA BERNARD L. , VELEZ YAMIL R. , WEST EMILY A.
Published: May 2024

In 2020, support for Joe Biden among Latina/o/x voters was 8 percentage points lower than support for Hillary Clinton in 2016, the largest drop of any racial/ethnic group. While much media and academic attention has focused on understanding the impact of misinformation, COVID-19 concerns, and racial animus on Latino voters in 2020, we take a step back and clarify the demographic and core ideological characteristics of Latino voters who voted for Donald Trump in 2020. Using a mix of national survey data, precinct returns, and voter file records, we disaggregate components of electoral change. We find evidence of an increasing alignment between Latinos’ ideology, issue positions, and vote choice. Correspondingly, we observe significant pro-Trump shifts among working-class Latinos and modest evidence of a pro-Trump shift among Latinos closer to the immigration experience. These findings, coupled with an analysis of the 2022 CES, point to a more durable Republican shift than currently assumed.
BOUNDS FOR MOMENTS OF QUADRATIC DIRICHLET CHARACTER SUMS
Authors: GAO PENG , ZHAO LIANGYI
Published: May 2024

We establish upper bounds for moments of smoothed quadratic Dirichlet character sums under the generalized Riemann hypothesis, confirming a conjecture of M. Jutila [‘On sums of real characters’, Tr. Mat. Inst. Steklova132 (1973), 247–250].
Distribution and potential habitat of the Vulnerable Himalayan wolf Canis lupus chanco in Bhutan
Authors: Dhendup Tashi , Letro  , Tandin  , Wangdi Sonam
Published: May 2024

The rare Himalayan wolf Canis lupus chanco is categorized as Vulnerable on the IUCN Red List, and there is limited knowledge of its ecology and distribution. In Bhutan, the Himalayan wolf is one of the least known carnivores. Our aims in this study were to map the current distribution of the wolf in Bhutan and to identify potential habitats within the country. We compiled 32 records of wolf presence from camera-trap surveys and, using a maximum entropy approach, we estimated a potential habitat of 2,431 km2, comprising c. 6.3% of Bhutan. However, wolf presence was localized and non-continuous. We recommend a detailed fine-scale habitat analysis in areas of potential habitat and genetic studies to investigate population structure. Knowledge of these matters will provide insights regarding connectivity and facilitate the development of conservation strategies for this threatened wolf.
The future of control/The control of the future: Global (dis)order and the weaponisation of everywhere in 2074
Authors: Lacy Mark
Published: May 2024

In this article, I am going to suggest that questions of societal and political control will be fundamental to the challenges humanity faces in the next 50 years, a continuation of the political and social problems of modernity but playing out in a range of political contexts and with a range of technological ‘tools’. Technicians of security will attempt to manage the disorder and insecurity that results from the potential weaponisation of everything, to use a phrase from Mark Galeotti, and the weaponisation of everywhere, a condition where the state will be seeking to control a range of emerging terrains and domains. But at the same time, while societies in 2074 might be confronting conditions that are an intensification of modern political problems, there is the possibility that the impact of climate emergencies and other ecological/technological dangers might produce global disorder unlike anything experienced in modernity, radically transforming (or mutilating) the ‘material’ foundations of international politics, presenting us with problems unlike anything encountered before. At this point, as Bruno Latour suggested, we might have to depart (for our own survival and the survival of others) from the ideas about politics and economy that we have ‘inherited’ from modernity.
On making peace with nature: Visions and challenges towards an ecological diplomacy
Authors: Constantinou Costas M. , Christodoulou Eleni
Published: May 2024

This article interrogates United Nations (UN) calls that ‘making peace with nature’ should become the crucial mission of the 21st century. It ponders the kind of diplomacy envisioned for such a reconciliation ecology to be credible. Drawing on one of the most promising and less known programmes of the UN system – namely, Harmony with Nature (HwN), which pioneers Earth-based jurisprudence and rights of nature – it conceptualises this diplomatic shift and assesses the conditions under which ecological diplomacy can be productively operationalised in the 21st century vis-à-vis a mere rhetorical appropriation and co-optation by intergovernmental agendas. Building on Indigenous thought and animist epistemologies, programmes such as HwN espouse a new relationship with Planet Earth and make it possible to explore ‘nature’ as diplomatic interlocutor. We argue that existing paradigms of peacebuilding fail to sufficiently capture the diplomatic aspects and complex local dynamics of the human–nature relationship and suggest a reconceptualisation based on an ecological diplomacy that is both expansive and transformative and views this relationship as one of troubled coexistence.
Coming of age within ‘implosion’
Authors: Bendfeldt Luise , Clifford Emily , Richards Hannah
Published: May 2024

In a recent article, Maria Eriksson Baaz and Swati Parashar1 trace the continued salience of Eurocentrism in critical International Relations (IR), demonstrating how the ‘master’s outlook’ continues to stifle the study of global politics; they ultimately encourage an unsettling and even implosion of the discipline. Starting from this proposed ‘implosion’ of critical IR, this article reflects on our hopes, as two current PhD candidates and one early career researcher in global politics, for teaching and learning in this future world. We begin by reflecting on our own complicity in reproducing the Western-centrism of the discipline and consider how this discomfort can be used productively. The article then considers the radical potential of the classroom and the necessity of empathetic, collaborative inquiry to the future of the discipline of global politics. We advocate for an IR which is imaginative, relational, messy, and vulnerable – and are hopeful about how this may animate a meaningful and sustainable implosion. Embracing our discomfort and the possibility of failure, we hope to contribute to the ongoing ‘unsettling’ of academia from the standpoint of incipient feminist scholars and hopeful early-career teachers.
Sexual Expression in Long-Term Care Institutions: Are We Ready for the Baby Boomer Generation?
Authors: Priede Angela , Reissing Elke D.
Published: May 2024

Baby boomers were at the forefront of profound social changes in sexual attitudes and many have expressed a desire to remain sexually active throughout their life course. The purpose of this survey study was to assess the perceived preparedness of Ontario’s long-term care (LTC) homes to meet the changing sexuality needs and expectations of LTC residents. We examined sexuality-related attitudes, including in the context of dementia, among 150 LTC administrators. Participants also completed a questionnaire assessing their experiences and perceptions regarding existing and anticipated supports, barriers, and priorities. Most participants demonstrated positive sexual attitudes; however, multiple challenges to meeting residents’ sexuality needs were noted, including assessing capacity to consent, limited privacy, staff training, conflicting attitudes, and a lack of adequate policy and guidelines. Challenges are broad and significant and considerable attention is required to meet the expectations of the next generation of LTC residents, including gender and sexual minority elders.
Ketamine subcutaneous continuous infusion for depressive symptoms at home: A case report beyond pain use
Authors: Simões Carolina , Julião Miguel , Calaveiras Patrícia , Câmara Paula , Santos Teresa
Published: May 2024

Objectives

Ketamine has been widely used in refractory pain as an opioid adjuvant. Evidence suggests that ketamine can also have an essential role in easing depressive symptoms. Its rapid onset of action makes it a valuable choice in palliative care.

Methods

We present a case of a 70-year-old man with stage IV renal carcinoma and bone metastasis. The main symptoms included neuropathic pain, depression, and a persistent and severe desire for death.

Results

We started continuous subcutaneous infusion with morphine 30 mg and ketamine 100 mg/day. The dose of ketamine was incremented to the maximum of 250 mg/day. During the 28-day treatment, we observed an overall improvement in neuropathic pain, depressive symptoms, and other end-of-life psychological aspects of distress. Only minor psychological side effects were identified, which were controlled by using midazolam in the continuous subcutaneous infusion.

Significance of results

Some studies have already demonstrated the benefits of ketamine use in alleviating depression, using parental infusion or oral formulas, which are administered in hospice care. Our report enhances the benefit of the subcutaneous route for palliative patients cared for at home.
Pflegebezogene Mikroschulungen
Authors: Schieron Martin
Published: May 2024

Das Praxishandbuch zur Mikroschulung zeigt Pflegenden, wie sie Klient*innen kleine Wissensportionen auf handlungsorientierte Weise innerhalb der Patientenedukation vermitteln können. Der erfahrene Experte und Autor für Patientenedukation

beschreibt die wichtigsten Merkmale der Mikroschulung
benennt zentrale Elemente einer Mikroschulung, wie Sachanalyse, Schulungsmaterial und -ablauf
skizziert den Schulungsablauf in zwölf Schritten
beschreibt die Einsatzfelder der Mikroschulung bezüglich Settings, Zielgruppen und Themen
nennt notwendige Kompetenzen von Schulenden und welche Anforderungen sich ihnen stellen
beschreibt, wie Mikroschulungen von Anwendenden evaluiert werden können und welche Studien zu ihrer Wirksamkeit vorliegen
erläutert wesentliche Aspekte der Anwendung von Mikroschulungen
fasst Grundlagen der Mikroschulung aus pädagogisch-didaktischer, pflegewissenschaftlicher und lernpsychologischer Perspektive verständlich zusammen
skizziert Grundlagen und Prinzipien des Erwachsenenlernens und differenziert Lernstile, -typen und -ziele
unterscheidet Einzel- und Gruppenschulungen als Formen der Mikroschulung
beschreibt detailliert, wie man Schulungsmaterialien beurteilt, erstellt und einsetzt
stellt Mikroschulungsbeispiele zu den Themen Dekubitus- und Sturzprophylaxe sowie zur subkutanen Injektion vor.

„Ich bin begeistert von dem Praxishandbuch. Der Aufbau ist logisch,
die Texte sind klar und verständlich geschrieben, es ist fachlich topp, praxisnah und umfassend. Die vielen Beispiele sind vielfältig und nachvollziehbar, Praxis und Theorie werden gut verknüpft. Wirklich ein schönes und gut lesbares Fachbuch zur Patientenedukation und Mikroschulung.“
Detlef Kraut, Lehrer für Pflege, Patientenschuler
Projected Intensified Hydrological Processes in the Three‐River Headwater Region, Qinghai Tibetan Plateau
Authors: Mahmood Rashid , Jia Shaofeng , Ai Zhipin
Published: May 2024

The Three‐River Headwater Region, also known as China's water tower, is highly sensitive to climate change and has experienced profound hydrological alterations in the last few decades. This study assessed the potential impacts of climate change on all the important hydrological components such as precipitation, evapotranspiration, streamflow, snow‐melt flow, and soil moisture (SM) content in the region. For this, climate data (i.e., temperature, precipitation, relative humidity, and windspeed) of three Global Climate Models (i.e., CanESM5, MPI‐ESM1.2‐HR, and NorESM2‐MM) was downscaled with the Statistical DownScaling Model (SDSM) and their ensemble was forced into a hydrological model to simulate the hydrological processes for 1981–2100. The screening process, which is central to all downscaling techniques, is very subjective in the SDSM. Therefore, we developed a quantitative screening approach by modifying the method applied by Mahmood and Babel (2013, https://doi.org/10.1007/s00704‐012‐0765‐0) for the selection of a set of logical predictors to cope with multi‐collinearity and their ranking. The analyses were performed for the near future period (NFP, 2021–2060) and far future period (FFP, 2061–2100) relative to the baseline period (BLP, 1981–2020). The results showed that the region will be hotter and wetter in the future, with intensive and frequent floods. For example, temperature, precipitation, evapotranspiration, and streamflow will increase by 1.0–1.5 (1–1.9)°C, 9–21 (15–27)%, 6–17 (9–29)%, and 9–46 (22–64)% in the NFP and by 2.0–2.8 (2.7–4.6)°C, 16–40 (43–87)%, 11–31 (24–73)%, and 20–95 (60–198)% in the FFP, respectively, under SSP2‐4.5 (SSP5‐8.5). Similar projections were explored for other hydrological components. Among all, surface flow showed an unprecedented increase (500%–1,000%) in the FFP. Peak flows will be much higher and will shift forward, and snowmelt will start earlier in the future. The results of the present study can be a good source for understanding the hydrological cycle and be used for the planning and management of water resources of the highly elevated and complex region of the Qinghai Tibetan Plateau.
Thank You to Our 2023 Peer Reviewers
Authors: Rajaram Harihar , Aiyyer Anantha , Camargo Suzana , Cappa Christopher D. , Dombard Andrew J. , Donohue Kathleen A. , Feakins Sarah , Flesch Lucy , Fulweiler Robinson , Ganju Neil , Giannini Alessandra , Gu Yu , Huber Christian , Ivanov Valeriy , Karnauskas Kristopher , Korte Monika , Lewis Kevin , Lu Gang , Magnusdottir Gudrun , Morlighem Mathieu , Oieroset Marit , Otsuka Yuichi , Prieto Germán A. , Qiu Bo , Russell Lynn , Su Hui , Sun Daoyuan , Wang Guiling , Wang Kaicun , Whalen Caitlin , White Angelicque E. , Williams Quentin , Yau Andrew
Published: May 2024

On behalf of the journal, AGU, and the scientific community, the editors of Geophysical Research Letters would like to sincerely thank those who reviewed manuscripts for us in 2023. The hours reading and commenting on manuscripts not only improve the manuscripts, but also increase the scientific rigor of future research in the field. With the advent of AGU's data policy, many reviewers have also helped immensely to evaluate the accessibility and availability of data, and many have provided insightful comments that helped to improve the data presentation and quality. We greatly appreciate the assistance of the reviewers in advancing open science, which is a key objective of AGU's data policy. We particularly appreciate the timely reviews in light of the demands imposed by the rapid review process at Geophysical Research Letters. We received 4,512 submissions in 2023 and 5,112 reviewers contributed to their evaluation by providing 8,587 reviews in total. We deeply appreciate their contributions.
Pure-high-even-order dispersion bound solitons complexes in ultra-fast fiber lasers
Authors: Han Ying , Gao Bo , Wen Honglin , Ma Chunyang , Huo Jiayu , Li Yingying , Zhou Luyao , Li Qi , Wu Ge , Liu Lie
Published: May 2024

Temporal solitons have been the focus of much research due to their fascinating physical properties. These solitons can form bound states, which are fundamentally crucial modes in fiber laser and present striking analogies with their matter molecules counterparts, which means they have potential applications in large-capacity transmission and all-optical information storage. Although traditionally, second-order dispersion has been the dominant dispersion for conventional solitons, recent experimental and theoretical research has shown that pure-high-even-order dispersion (PHEOD) solitons with energy-width scaling can arise from the interaction of arbitrary negative-even-order dispersion and Kerr nonlinearity. Despite these advancements, research on the bound states of PHEOD solitons is currently non-existent. In this study, we obtained PHEOD bound solitons in a fiber laser using an intra-cavity spectral pulse shaper for high-order dispersion management. Specifically, we experimentally demonstrate the existence of PHEOD solitons and PHEOD bound solitons with pure-quartic, -sextic, -octic, and -decic dispersion. Numerical simulations corroborate these experimental observations. Furthermore, vibrating phase PHEOD bound soliton pairs, sliding phase PHEOD bound soliton pairs, and hybrid phase PHEOD bound tri-soliton are discovered and characterized. These results broaden the fundamental understanding of solitons and show the universality of multi-soliton patterns.
Highly homogeneous zero-index metamaterials make devices more compact and perform better
Authors: Jiang Wei-Xiang
Published: May 2024

A highly homogeneous microwave zero-index metamaterial based on high-permittivity SrTiO3 ceramics is demonstrated to realize the small-aperture high-directivity antenna. Such a novel technique is a remarkable step forward to develop compact devices with better performance.
Glioblastoma stem cells deliver ABCB4 transcribed by ATF3 via exosomes conferring glioblastoma resistance to temozolomide
Authors: Xu Xiangdong , Zheng Yaofeng , Luo Linting , You Zhongsheng , Chen Huajian , Wang Jihui , Zhang Fabing , Liu Yang , Ke Yiquan
Published: May 2024

Glioblastoma stem cells (GSCs) play a key role in glioblastoma (GBM) resistance to temozolomide (TMZ) chemotherapy. With the increase in research on the tumour microenvironment, exosomes secreted by GSCs have become a new focus in GBM research. However, the molecular mechanism by which GSCs affect drug resistance in GBM cells via exosomes remains unclear. Using bioinformatics analysis, we identified the specific expression of ABCB4 in GSCs. Subsequently, we established GSC cell lines and used ultracentrifugation to extract secreted exosomes. We conducted in vitro and in vivo investigations to validate the promoting effect of ABCB4 and ABCB4-containing exosomes on TMZ resistance. Finally, to identify the transcription factors regulating the transcription of ABCB4, we performed luciferase assays and chromatin immunoprecipitation-quantitative PCR. Our results indicated that ABCB4 is highly expressed in GSCs. Moreover, high expression of ABCB4 promoted the resistance of GSCs to TMZ. Our study found that GSCs can also transmit their highly expressed ABCB4 to differentiated glioma cells (DGCs) through exosomes, leading to high expression of ABCB4 in these cells and promoting their resistance to TMZ. Mechanistic studies have shown that the overexpression of ABCB4 in GSCs is mediated by the transcription factor ATF3. In conclusion, our results indicate that GSCs can confer resistance to TMZ in GBM by transmitting ABCB4, which is transcribed by ATF3, through exosomes. This mechanism may lead to drug resistance and recurrence of GBM. These findings contribute to a deeper understanding of the mechanisms underlying drug resistance in GBM and provide novel insights into its treatment.