bluuebunny/crossref_metadata_2025 huggingface dataset:
Functional pathophysiology of SARS-CoV-2-induced acute lung injury and clinical implications
Authors: Habashi Nader M. , Camporota Luigi , Gatto Louis A. , Nieman Gary
Published: January 2021

The worldwide pandemic caused by the SARS-CoV-2 virus has resulted in over 84,407,000 cases, with over 1,800,000 deaths when this paper was submitted, with comorbidities such as gender, race, age, body mass, diabetes, and hypertension greatly exacerbating mortality. This review will analyze the rapidly increasing knowledge of COVID-19-induced lung pathophysiology. Although controversial, the acute respiratory distress syndrome (ARDS) associated with COVID-19 (CARDS) seems to present as two distinct phenotypes: type L and type H. The “L” refers to low elastance, ventilation/perfusion ratio, lung weight, and recruitability, and the “H” refers to high pulmonary elastance, shunt, edema, and recruitability. However, the LUNG-SAFE (Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure) and ESICM (European Society of Intensive Care Medicine) Trials Groups have shown that ∼13% of the mechanically ventilated non-COVID-19 ARDS patients have the type-L phenotype. Other studies have shown that CARDS and ARDS respiratory mechanics overlap and that standard ventilation strategies apply to these patients. The mechanisms causing alterations in pulmonary perfusion could be caused by some combination of 1) renin-angiotensin system dysregulation, 2) thrombosis caused by loss of endothelial barrier, 3) endothelial dysfunction causing loss of hypoxic pulmonary vasoconstriction perfusion control, and 4) hyperperfusion of collapsed lung tissue that has been directly measured and supported by a computational model. A flowchart has been constructed highlighting the need for personalized and adaptive ventilation strategies, such as the time-controlled adaptive ventilation method, to set and adjust the airway pressure release ventilation mode, which recently was shown to be effective at improving oxygenation and reducing inspiratory fraction of oxygen, vasopressors, and sedation in patients with COVID-19.
Physiological changes and compensatory mechanisms by the action of respiratory muscles in a porcine model of phrenic nerve injury
Authors: LoMauro Antonella , Aliverti Andrea , Perchiazzi Gaetano , Frykholm Peter
Published: January 2021

This was the first (to our knowledge) implanted porcine model of phrenic nerve injury with a detailed multidimensional analysis of different degrees of diaphragmatic paralysis (unilateral and bilateral). Noninvasive thoracoabdominal volume and asynchrony assessment was shown to be useful in estimating the extent of diaphragmatic dysfunction and the consequent coordinated reorganization of nondiaphragmatic respiratory muscles. High level of pressure support ventilation was proved to obscure the interaction and compensation of respiratory muscles to deal with phrenic nerve injury.
Soluble ICAM-1 is modulated by hyperbaric oxygen treatment and correlates with disease severity and mortality in patients with necrotizing soft-tissue infection
Authors: Hedetoft Morten , Moser Claus , Jensen Peter Østrup , Vinkel Julie , Hyldegaard Ole
Published: January 2021

HBO2treatment may be a promising immunomodulatory agent by increasing sICAM-1, thereby lowering risk of collateral damage, especially in the most critically ill patients. sICAM-1 is associated with disease severity in NSTI as emphasized by significant correlations with SAPS II. Low sICAM-1 levels are an independent risk factor of 90-day mortality and appeared to give a good level of diagnostic accuracy, suggesting that sICAM-1 can be used as a prognostic biomarker for NSTI.
The Combination of Jiedu Xiaoluo Decoction with Autologous Peripheral Blood Stem Cell Transplantation (APBSCT) Accelerates Disease Remission of Non-Hodgkin Lymphoma
Authors: Zhang Yu , Xiang Jingjing , Zhu Ni , Ge Hangping , Sheng Xianfu , Deng Shu , Chen Junfa , Yu Lihong , Zhou Yan , Shen Jianping
Published: January 2021

Objective. This study aimed to explore the therapeutic effects of autologous peripheral blood stem cell transplantation (APBSCT) with Jiedu Xiaoluo decoction (JDX) on non-Hodgkin lymphoma (NHL). Method. B lymphoma cells A20 were used to establish nude mice-transplanted tumor model. The peripheral blood of mice was analyzed by automatic blood cell counter. Inflammatory cytokines in tumor tissues were measured by ELISA, real-time qRT-PCR, and western blotting assays. Immunohistochemical staining was employed to evaluate tumor cell growth and apoptosis. CCK8 and Transwell assays were used to detect cell viability, migration, and invasion. Cell apoptosis in vitro was evaluated with flow cytometry. Result. In the in vitro co-culture system of A20 cells and hemopoietic stem cells (HSC), JDX notably inhibited the proliferation, migration, and invasion and promoted apoptosis of A20 cells compared to HSC treatment alone. In animal tumor xenografts of NHL, the combination of APBSCT with JDX significantly promoted hematopoietic reconstitution, inhibited tumorigenesis of A20 cell, promoted the inflammatory microenvironment remission, inhibited cell proliferation, and promoted apoptosis compared to APBSCT alone. Conclusion. The combination of APBSCT with JDX might be an effective strategy to treat NHL through inhibiting tumorigenesis and reconstructing hematopoietic and immune microenvironment. Our finding provided a novel insight into the clinical application of Traditional Chinese Medicine (TCM) against NHL.
Determination of Pharmaceutical Residues by UPLC-MS/MS Method: Validation and Application on Surface Water and Hospital Wastewater
Authors: Van Hoi Bui , Vu Cam-Tu , Phung-Thi Lan-Anh , Thi Nguyen Thao , Nguyen Phuong Thanh , Mai Huong , Le Phuong-Thu , Nguyen Thanh-Hien , Thanh Duong Dao , Nguyen Thi Hue , Le-Van Dung , Chu Dinh Binh
Published: January 2021

In this study, an analytical method for the simultaneous determination of 7 major pharmaceutical residues in Vietnam, namely, carbamazepine, ciprofloxacin, ofloxacin, ketoprofen, paracetamol, sulfamethoxazole, and trimethoprim, in surface water and hospital wastewater has been developed. The method includes enrichment and clean-up steps by solid phase extraction using mix-mode cation exchange, followed by identification and quantification using an ultrahigh-performance liquid chromatography and tandem mass spectrometry and employing electrospray ionization (UPLC-ESI-MS/MS). Seven target compounds were separated on the reversed phase column and detected in multiple reaction monitoring (MRM) mode within 6 minutes. The present study also optimized the operating parameters of the mass spectrometer to achieve the highest analytical signals for all target compounds. All characteristic parameters of the analytical method were investigated, including linearity range, limit of detection, limit of quantification, precision, and accuracy. The important parameter in UPLC-ESI-MS/MS, matrix effect, was assessed and implemented via preextraction and postextraction spiking experiments. The overall recoveries of all target compounds were in the ranges from 55% to 109% and 56 % to 115% for surface water and hospital wastewater, respectively. Detection limits for surface water and hospital wastewater were 0.005–0.015 µg L−1 and 0.014–0.123 µg L−1, respectively. The sensitivity of the developed method was allowed for determination of target compounds at trace level in environmental water samples. The in-house validation of the developed method was performed by spiking experiment in both the surface water and hospital wastewater matrix. The method was then applied to analyze several surface water and hospital wastewater samples taken from West Lake and some hospitals in Vietnam, where the level of these pharmaceutical product residues was still missed. Sulfamethoxazole was present at a high detection frequency in both surface water (33% of analyzed samples) and hospital wastewater (81% of analyzed samples) samples.
A Novel Optimal Selection Algorithm for Agricultural Trade Export in Blockchain‐Enabled Internet of Things
Authors: Cao Shuhao
Published: January 2021

With the maturity of modern science and technology, such as networks and computers, Internet of Things has been widely used in various fields of industry, opening up a new situation for the development of the industry and creating a broader development platform. This paper systematically analyzes the characteristics and changes of the commodity structure, regional structure, market structure, and main structure of export management of agricultural products. The proposed algorithm uses computer technology, network technology, and remote communication technology, electronic, digital, and network—the entire business process of business. The empirical analysis shows that the structure of agricultural product export trade reflects the endowment and comparative advantage of agricultural resources in China. The proposed blockchain technology supports and guides agricultural export enterprises to develop their own brands, strengthen the quality and safety management of agricultural products, and innovate and expand the policy support system for optimizing the structure of agricultural product export trade. By optimizing the export mode of agricultural trade, we can achieve the purpose of increasing the export volume of agricultural products and the total value of trade exports. The experimental results show the effectiveness of the proposed algorithm, which can greatly improve the volume of trade exports and the total value of trade exports.
High Expression of VSTM2L Induced Resistance to Chemoradiotherapy in Rectal Cancer through Downstream IL-4 Signaling
Authors: Liu Hao , Zhang Zhenzhan , Zhen Peilin , Zhou Meijuan
Published: January 2021

Background. Preoperative chemoradiotherapy (pCRT) is a common and essential therapeutic strategy for patients with locally advanced rectal cancer (LARC), but poor tumor response and therapeutic resistance to chemoradiotherapy have appeared usually among persons and affected those patients’ survival prognosis. The resistance to chemoradiotherapy in rectal cancer is difficult to predict. This study was aimed at evaluating the role of V-set and transmembrane domain containing 2 like protein (VSTM2L) in resistance to chemoradiotherapy in rectal cancer. Methods. Analysis of the GEO profiling datasets of rectal cancer patients receiving pCRT disclosed that VSTM2L as a candidate gene was significantly upregulated in nonresponders of rectal cancer with pCRT. The mRNA and protein expression of VSTM2L was detected by quantitate real-time PCR, western blotting, and immunohistochemistry in six rectal cancer biopsy tissues before pCRT. Furthermore, the rectal cancer patient-derived organoids were cultured to evaluate the association of VSTM2L expression and tumor response to CRT. Overexpression of VSTM2L in cancer cells treated with CRT was analyzed for the function of cell proliferation and viability, clone formation, DNA damage repair, and apoptosis ability. The GSEA and RNA-sequence analysis were used to find the downstream mechanism of VSTM2L overexpression in cells treated with CRT. Results. The mRNA levels of VSTM2L were significantly downregulated in normal rectal tissues compared to tumor tissues and were upregulated in nonresponders of rectal cancer patients receiving pCRT and positively correlated with poor survival prognosis from GEO datasets. High expression of VSTM2L was significantly associated with tumor regression after pCRT (

P
=
0.030

). Moreover, high expression of VSTM2L reduced γ-H2AX expression in rectal cancer patient-derived organoids treated with CRT. The overexpression of VSTM2L in colorectal cancer cells induced resistance to CRT via promoting cell proliferation and inhibiting apoptosis. The molecular mechanism revealed that the overexpression of VSTM2L induced resistance to CRT through downstream IL-4 signaling affecting the progress of cell proliferation and apoptosis. Conclusion. The high expression of VSTM2L induced resistance to CRT, and adverse survival outcomes served as a prognostic factor in patients with rectal cancer receiving pCRT, suggesting that VSTM2L high expression may be a potential resistant predictable biomarker for LARC patients receiving pCRT.
Recovery Method and Parameter Optimization of a Pilot Test for Conformance Control Flooding and Thermal Recovery in the Offshore Heavy Oilfield
Authors: Zhou Yanxia , Lu Xiangguo , Cao Bao , Liu Yigang , Zhang Yunbao , Zhong Xun
Published: January 2021

NB35-2 oilfield is a typical offshore sandstone reservoir with viscous crude oil and high permeability. Due to the inherent severe heterogeneity, the efficiency of conventional water flooding is pretty low and usually accompanied with early water breakthrough. In order to recover the residual oil and better realize its potential, applications of enhanced oil recovery (EOR) technology are necessary. However, the selection of EOR method and related parameters may directly impact the final results and can be noticeably different for different reservoirs; therefore, to optimize the oil production rate and final oil recovery, systematical optimization of every detail based on the condition of a specific reservoir is of key importance. In this paper, physical simulations were first conducted to select the best recovery methods for the target area based on the static geophysical model under the guidance of reservoir engineering theory. Then, detailed development variants for each method were determined by numerical simulation with the support of data obtained from previous pilot tests (polymer gel flooding and thermal fluid huff and puff) conducted in this area. Three exploitation methods were developed for the target well group, including polymer gel flooding (conformance control, Pattern 1), steam huff and puff (thermal recovery method, Pattern 2), and a combination of polymer gel flooding and steam huff and puff (conformance control and thermal recovery, Pattern 3). The numerical simulation result also showed that Pattern 3 yielded the highest oil recovery. Moreover, the amount of additional oil being recovered by applying Pattern 3 was even higher than the total additional oil being extracted by Patterns 1 and 2. In addition, sensitivity analysis was conducted to rank the most important parameters based on the three Patterns. At last, it is thought that the synergistic effect between conformance control and thermal recovery made more oil recovered, which was intuitively clarified in the mechanism analysis.
Computing Analysis of Zagreb Indices for Generalized Sum Graphs under Strong Product
Authors: Javaid Muhammad , Javed Saira , Alanazi Abdulaziz Mohammed , Alotaibi Majdah R.
Published: January 2021

Numerous studies based on mathematical models and tools indicate that there is a strong inherent relationship between the chemical properties of the chemical compounds and drugs with their molecular structures. In the last two decades, the graph-theoretic techniques are frequently used to analyse the various physicochemical and structural properties of the molecular graphs which play a vital role in chemical engineering and pharmaceutical industry. In this paper, we compute Zagreb indices of the generalized sum graphs in the form of the different indices of their factor graphs, where generalized sum graphs are obtained under the operations of subdivision and strong product of graphs. Moreover, the obtained results are illustrated with the help of particular classes of graphs and analysed to find the efficient subclass with dominant indices.
The Expression of Seismic Surrounding Rock Pressure for a Shallow Tunnel Is Derived Using the Pseudostatic Method
Authors: Wei Zhengde , Zhu Yanpeng
Published: January 2021

Terzaghi developed a generalized expression of the vertical surrounding rock pressures of shallow tunnels by considering the limit equilibrium of soil masses. In this paper, based on the Terzaghi failure mode, the pseudostatic method is used to derive this expression under seismic loading conditions. The surrounding rock in the fractured zone of the tunnel side wall is analyzed as an isolated body using the limit equilibrium method to obtain the explicit calculation expressions of the horizontal surrounding rock pressures of a shallow tunnel under seismic loading. Case analysis indicates that the proposed method is feasible. In addition, the influence of the seismic acceleration coefficient on surrounding rock pressures is further discussed. The results show that the horizontal surrounding rock pressure decreases with the increase of seismic acceleration coefficients. The vertical surrounding rock pressure increases as the horizontal seismic acceleration coefficient increases, and it decreases with the increase of the vertical seismic acceleration coefficient, and the effect of the seismic acceleration coefficient on surrounding rock pressure is significant. The study results can provide reference for the seismic safety evaluation and structural seismic design of shallow tunnels.
Collaborative Product Portfolio Design Based on the Approach of Multichoice Goal Programming
Authors: Wang Sheng-Yuan , Chen Wan-Ming , Liu Ying
Published: January 2021

Product portfolio optimization is a typical multiobjective problem. The multichoice goal programming method becomes a popular means of resolving multiobjective decision problems. However, the classic multichoice goal programming method treats the product portfolio optimization in isolation and does not consider the mutual influence between portfolio products. Researchers should consider the interaction between products in portfolio optimization so that they can be adjusted to “real world” problems. The interaction between products can be explained by population dynamics. Logistic model is a classical method to analyze the population interaction. The equilibrium point of logistic model can show the ideal state of product population coordinated development. The combination of logistic and multichoice goal programming method is an effective approach to analyze the interaction of product portfolio. This paper therefore proposes a new alternative method to formulate the multiobjective problem and also uses an illustrative example to demonstrate the usefulness of the proposed method. The comparative analysis of model optimization results shows that logistic multichoice goal programming model can take into account resource constraints, product collaboration, and output maximization. Logistic multichoice goal programming model shows good performance in the aspects of operation complexity, operation time, sensitivity analysis, and collaborative entropy evaluation.
Study on the Process and Characteristics of Clogging for Ceramic Permeable Brick
Authors: Lin Zizeng , Yang Hai , Chen Huiming
Published: January 2021

A ceramic permeable brick was selected for study in a device that was designed to fully investigate the process and characteristics of clogging in permeable bricks. In order to evaluate the permeability influenced by clogging, a simulated rainfall was filtered through the permeable brick placed in an innovative device. The macroscopic and microscopic changes in the brick and the filtrate were all measured to fully investigate the causes and process of clogging. Then, the mechanism of clogging in the permeable brick pores was further discussed. The results showed that the clogging risk of permeable brick was extremely high, and it can result in a complete clogging in only 5–10 years under the experimental conditions. The permeability coefficient and porosity both decreased exponentially with the increase in filtrate, which was attributed to the clogging of the internal pore structure due to particle interception. The chord size distribution results stressed that the blockage mainly occurred in the upper layer pores in the range of 0.5–1.5 mm, which is relatively sensitive to clogging due to the particle size distribution in rain water. The particle size distribution of the influent and effluent indicated that the clogging process could completely remove particles larger than 88 µm but showed variable removal efficiency for particles with sizes of 20–88 µm. This research offers new insight into the clogging of permeable bricks and provides theoretical guidance for restoring the brick permeability.
Direct Shear Creep Characteristics and Microstructure of Fiber‐Reinforced Soil
Authors: Tang Hao , Li Huahua , Duan Zhao , Liu Chiyang , Wu Guannan , Luo Jinzhi
Published: January 2021

Fiber‐reinforced soil is an excellent engineering material that has become a focus of research. Most studies focus on the conventional mechanical properties of reinforced soil, such as its tensile, compressive, and shear strength, and rarely study its creep‐related mechanical properties. However, when such soil is used as backfill, the creep effect should not be ignored. This study explored the characteristics of creep mechanics in reinforced soil, the fiber‐reinforcement mechanism, and the dynamics of microstructures before and after creep tests. Direct shear creep tests were carried out using a direct shear creep tester on soil reinforced with natural palm fibers of equal length (1.5 cm) in different amounts (0%, 0.2%, 0.6%, 1.0%). Microscale tests were carried out on the reinforced soil samples before and after the creep tests by polarized light and scanning electron microscopy. The results show that the fiber reinforcement can restrain the deformation and enhance the long‐term strength of soil. However, a nonlinear relationship between the reinforcement effect and fiber content was found, with 0.6% being the optimal content. Palm fibers have rough surfaces, grooves, and independent pore chambers, which increase the effective contact area and interaction with the soil. With increases in fiber content, the fibers interweave to form a nestled network structure, which increases the strength and integrity of the soil. Fiber addition changes the microstructure of the soil pores; the proportion of large pores decreases and that of small pores increases. Under the effect of creep, the pore changes follow the principle of pore homogenization; large pores are destroyed and transformed into small pores, causing the porosity of reinforced soil to decrease faster and be less porous than unreinforced soil. This research can provide technical reference for the engineering application of palm fiber‐reinforced soil.
Dynamic Analysis and Robust Control of a Chaotic System with Hidden Attractor
Authors: Tian Huaigu , Wang Zhen , Zhang Peijun , Chen Mingshu , Wang Yang
Published: January 2021

In this paper, a 3D jerk chaotic system with hidden attractor was explored, and the dissipativity, equilibrium, and stability of this system were investigated. The attractor types, Lyapunov exponents, and Poincare section of the system under different parameters were analyzed. Additionally, a circuit was carried out, and a good similarity between the circuit experimental results and the theoretical analysis testifies the feasibility and practicality of the original system. Furthermore, a robust feedback controller was designed based on the finite‐time stability theory, which guarantees the synchronization of 3D jerk master‐slave system in finite time and asymptotically converges to the origin. Finally, we also give verification for the discussion in this paper by numerical simulation.
MicroRNA-155: Regulation of Immune Cells in Sepsis
Authors: Chen Ming , Wang Fuquan , Xia Haifa , Yao Shanglong
Published: January 2021

MicroRNAs are small noncoding RNAs which regulate gene expression at the posttranscriptional level. miR-155 is encoded by the miR-155 host gene (miR155HG), also known as the noncoding B cell integration cluster (BIC). MicroRNAs are widely expressed in various hematopoietic cells and are involved in regulating the immune system. In this review, we summarized how miR-155 modulates specific immune cells and the regulatory role of miR-155 in sepsis. miR-155 is expressed by different populations of innate and adaptive immune cells and is involved in the regulation of development, proliferation, and function in these cells. Sepsis is associated with uncontrollable inflammatory responses, accompanied by unacceptably high mortality. Due to the inadequacy of diagnostic markers as well as treatment strategies, treating sepsis can be a huge challenge. So far, a large number of experiments have shown that the expression of miR-155 is increased at an early stage of sepsis and that this increase is positively correlated with disease progression and severity. In addition, by blocking the proinflammatory effects of miR-155, it can effectively improve sepsis-related organ injury, providing novel insights to identify potential biomarkers and therapeutic targets for sepsis. However, since most of the current research is limited to animal experiments, further clinical research is required to determine the function of miR-155 and its mechanism related to sepsis.
Particle Flow Code Simulation of the Characteristics of Crack Evolution in Rock-Like Materials with Bent Cracks
Authors: Ma Zhanguo , Cheng Shixing , Gong Peng , Hu Jun , Chen Yongheng
Published: January 2021

The distribution and propagation of rock cracks have a significant impact on geotechnical engineering. Taking rock-like materials with bent cracks as the research object, the particle flow code in two dimensions numerical simulation method was used to study the impact of the bend number on rock-like materials strength and crack evolution. According to the results, when the bend number was 1, 3, and 7, the strength of the specimens gradually increased; the elasticity modulus did not change significantly with the crack bend number. Uniaxial compression generated tensile cracks in all the specimens with bent cracks, but in terms of failure mode, the specimens with 0 bend tended to suffer penetrating failure along the fracture strike, while the specimens with 1, 3, and 7 bend tended to suffer penetrating failure along the diagonal direction. Both the fractal dimension and bend number were positively correlated with strain; with the gradual increase of the stress percentage, the damage variable of the specimens gradually increased at a growing rate. The research results provide a reference for predicting the stability of the underground engineering surrounding rocks containing bent cracks.
Elevation of Inflammatory Cytokines and Proteins after Intra-Articular Ankle Fracture: A Cross-Sectional Study of 47 Ankle Fracture Patients
Authors: Pham That Minh , Frich Lars Henrik , Lambertsen Kate Lykke , Overgaard Søren , Schmal Hagen
Published: January 2021

Introduction. Intra-articular fractures are the leading etiology for posttraumatic osteoarthritis (PTOA) in the ankle. Elevation of proinflammatory cytokines following intra-articular fracture may lead to synovial catabolism and cartilage degradation. We aimed to compare cytokine levels in injured and healthy ankle joints, examine the longer-term cytokine levels in fractured ankles, and investigate the association between cytokine levels in fractured ankles and plasma. Materials and Methods. In this cross-sectional study, synovial fluid (SF) and plasma of forty-seven patients with acute intra-articular ankle fractures and eight patients undergoing implant removal were collected prior to surgery. We determined concentrations of sixteen inflammatory cytokines, two cartilage degradation proteins, and four metabolic proteins and compared the levels in acutely injured ankles with those of the healthy contralateral side or during metal removal. Cytokine levels in injured ankles were also compared to serum cytokine levels. Nonparametric Wilcoxon rank-sum and Spearman tests were used for statistical analysis, and a

p

value below 0.05 was considered significant. Results. Compared to the healthy ankles, the synovial fluid in ankles with acute intra-articular fracture had elevated levels of several proinflammatory cytokines and proteases (IL-1β, IL-2, IL-6, IL-8, IL-12p70, TNF, IFNγ, MMP-1, MMP-3, and MMP-9) and anti-inflammatory cytokines (IL-1RA, IL-4, IL-10, and IL-13). The levels of cartilage degradation products (ACG, CTX-2) and metabolic mediators (TGF-β1 and TGF-β2) were also significantly higher. Synovial concentrations of ACG, IL-12-p70, IFNγ, IL-4, and bFGF correlated with serum levels. While most of the examined synovial cytokines were unchanged after implant removal, IL-4 and IL-6 levels were upregulated. Conclusions. We show that an acute ankle fracture is followed by an inflammatory reaction and cartilage degeneration. These data contribute to the current understanding of the protein regulation behind the development of PTOA and is a further step towards supplementing the current surgical treatment. This cross-sectional study was “retrospectively registered” on the 31th October 2017 at ClinicalTrials.gov (NCT03769909). The registration was carried out after inclusion of the first patient and prior to finalization of patient recruitment and statistical analyses: https://clinicaltrials.gov/ct2/show/NCT03769909?term=NCT03769909&draw=2&rank=1.
Challenges and Opportunities for Communication about the Role of Genomics in Public Health
Authors: Allen Caitlin G. , Green Ridgely Fisk , Bowen Scott , Dotson W. David , Yu Wei , Khoury Muin J.
Published: January 2021

Despite growing awareness about the potential for genomic information to improve population health, lingering communication challenges remain in describing the role of genomics in public health programs. Identifying and addressing these challenges provide an important opportunity for appropriate communication to ensure the translation of genomic discoveries for public health benefits. In this commentary, we describe 5 common communication challenges encountered by the Centers for Disease Control and Prevention’s Office of Genomics and Precision Public Health based on over 20 years of experience in the field. These include (1) communicating that using genomics to assess rare diseases can have an impact on public health; (2) providing evidence that genetic factors can add important information to environmental, behavioral, and social determinants of health; (3) communicating that although genetic factors are nonmodifiable, they can increase the impact of public health programs and communication strategies; (4) addressing the concern that genomics is not ready for clinical practice; and (5) communicating that genomics is valuable beyond the domain of health care and can be integrated as part of public health programs. We discuss opportunities for addressing these communication challenges and provide examples of ongoing approaches to communication about the role of genomics in public health to the public, researchers, and practitioners.
Medium Cut-Off Dialysis Membranes: Can They Have Impact on Outcome of COVID-19 Hemodialysis Patients?
Authors: Yalın Serkan Feyyaz , Altıparmak Mehmet Rıza , Dincer Mevlut Tamer , Yadigar Serap , Murt Ahmet , Parmaksiz Ergun , Ronco Claudio
Published: January 2021

Introduction: Severe acute respiratory syndrome coronavirus-2 may lead to high levels of expression of inflammatory cytokines. Medium cut-off (MCO) membranes may make greater clearances for large-middle molecules (including cytokines) than low-flux (LF) membranes. In this study, we aimed to evaluate the impact of MCO membranes on outcome of COVID-19 patients on hemodialysis (HD). Methods: Sixty COVID-19 HD patients were included in this study. The patients were categorized into 2 groups regarding type of HD membranes. Clinical data were taken from medical records. Results: Initial crp and ferritin levels, which are surragates of cytokine storm and severity of disease in COVID-19, were significantly higher in MCO membrane group compared to LF group (p = 0.037 and 0.000, respectively). Although there were more patients with severe disease in MCO group, there were no significant differences regarding need for intensive care unit and death. Conclusion: It may be an option to use MCO membranes in HD patients with COVID-19 in order to reduce cytokine levels and prevent cytokine storm.
Cartas percentílicas da proficiência motora de crianças com idades entre os seis e os 10 anos
Authors: Ferreira Luciana , Vieira José Luiz Lopes , Silva Pâmela Norraila da , Rocha Franciele Ferreira da , Caçola Priscila , Chaves Raquel Nichele de
Published: January 2021

Este estudo teve como objetivos principais (i) apresentar valores normativos para os oito subtestes do Teste de Proficiência Motora Bruininks-Oseretsky (BOT-2) e (ii) contrastar com os valores sugeridos no manual do teste original. A amostra foi constituída por 931 crianças com idade entre os seis e 10 anos,de ambos os sexos, provenientes do município de Maringá-PR. Para a avaliação da profi ciência motora foi utilizado o BOT-2. A construção dos valores de referência percentílica foi efetuada com base no método LMS, implementado no software LMSchartmaker Pro versão 2.54. As meninas obtiveram maiores escores nos subtestes precisão motora fina, integração motora fina, destreza manual e equilíbrio. Os meninos apresentaram maiores escores na coordenação de membros superiores, velocidade e agilidade e força muscular. As crianças maringaenses avaliadas apresentaram valores superiores às crianças norte-americanas nos subtestes de coordenação bilateral, velocidade e agilidade, equilíbrio e coordenação dos membros superiores. Os resultados expressam a forte variabilidade interindividual em termos de profi ciência motora, bem como diferenças entre meninos e meninas. As curvas ilustram o aumento dos níveis de proficiência motora ao longo das idades, com trajetórias distintas para cada subteste. Desse modo, a utilização dos valores normativos apresentados neste estudo poderá auxiliar a ação pedagógica nos contextos escolares e esportivos, contribuindo para o planejamento de intervenções motoras mais efetivas.
Análise das práticas de governança corporativa e sua relação com o compartilhamento do conhecimento nas instituições do terceiro setor
Authors: Conduta Luis Fernando , Vitoriano Marcia Cristina de Carvalho Pazin
Published: January 2021

As mudanças ocorridas no cenário empresarial brasileiro, com a ampliação da complexidade de sua atuação e surgimento de novos atores no ambiente organizacional têm influenciado diretamente as organizações do Terceiro Setor, representadas por fundações e associações que, assim como as empresas, necessitam de boas práticas de governança, o que inclui o compartilhamento de conhecimento. Em função desse contexto surge o problema de pesquisa que se traduz nas seguintes questões: as associações assistenciais atendem as exigências trazidas pela prática de Governança Corporativa? Elas apresentam em sua estrutura os pilares de Gestão do Conhecimento e esses promovem o compartilhamento de conhecimento nessas instituições? Considerando essas questões    o presente estudo teve como objetivo geral analisar as atividades das Associações Assistenciais, buscando compreender se essas instituições possuem os pilares necessários para a aplicação das práticas de Governança Corporativa bem como se essas práticas promoverão o compartilhamento do conhecimento nessas instituições. A metodologia caracteriza-se como qualitativa, de natureza exploratória e descritiva. Como método de pesquisa foi utilizado o estudo de caso múltiplo, tendo como universo de pesquisa um conjunto de associações de cunho assistencial localizadas no munícipio de Curitiba-PR. Os resultados obtidos demonstram que as Associações estudadas compreendem a importância das boas práticas de Governança Corporativa e seguem alguns de seus princípios, atendendo parcialmente aos pilares, de forma intrínseca ou não; têm ciência da aplicação ou aplicam-nos mesmo sem os conhecer, respectivamente. Pode-se concluir que as organizações estudadas atendem parcialmente, às exigências expostas pela Governança Corporativa, mesmo que muitas vezes o façam de maneira instintiva.
Empreendedorismo, privatização e o trabalho sujo da educação
Authors: Catini Carolina
Published: January 2021

O artigo apresenta uma crítica das mudanças pelas quais o Ensino Médio está passando, presididas pelo empresariado organizado em think tanks de política e trabalho social educativo. O protagonismo juvenil e o empreendedorismo, que estão no núcleo da reforma e das propostas curriculares flexíveis, em conjunto com os projetos de vida e as habilidades socioemocionais, são estudados a partir das respostas do empresariado às ocupações secundaristas e, sobretudo, pela análise da experiência precedente da educação não formal da juventude periférica organizada por tais institutos e fundações sociais de formação. Conclui-se com a análise da educação estrategicamente transformada em mecanismo de gestão e contenção dos conflitos sociais, além de disciplinamento para o trabalho precário.
Reforma do Ensino Médio e a formação técnica e profissional
Authors: Piolli Evaldo , Sala Mauro
Published: January 2021

Este trabalho analisa as implicações da reforma do Ensino Médio e seus desdobramentos nas mudanças curriculares previstas com a introdução dos itinerários formativos, em especial de formação técnica e profissional. A centralidade dada, na reforma, ao itinerário de formação técnica e profissonal e sua implementação, como no caso da rede estadual paulista, se apresenta como um elemento que reproduz e aprofunda o dualismo estrutural, criando outra dualidade dentro dessa dualidade através da oferta predominante de modalidades de cursos de qualificação aligeirados.
Open Science and Data Science
Authors: Wittenburg Peter
Published: January 2021

Data Science (DS) as defined by Jim Gray is an emerging paradigm in all research areas to help finding non-obvious patterns of relevance in large distributed data collections. “Open Science by Design” (OSD), i.e., making artefacts such as data, metadata, models, and algorithms available and re-usable to peers and beyond as early as possible, is a pre-requisite for a flourishing DS landscape. However, a few major aspects can be identified hampering a fast transition: (1) The classical “Open Science by Publication” (OSP) is not sufficient any longer since it serves different functions, leads to non-acceptable delays and is associated with high curation costs. Changing data lab practices towards OSD requires more fundamental changes than OSP. 2) The classical publication-oriented models for metrics, mainly informed by citations, will not work anymore since the roles of contributors are more difficult to assess and will often change, i.e., other ways for assigning incentives and recognition need to be found. (3) The huge investments in developing DS skills and capacities by some global companies and strong countries is leading to imbalances and fears by different stakeholders hampering the acceptance of Open Science (OS). (4) Finally, OSD will depend on the availability of a global infrastructure fostering an integrated and interoperable data domain—“one data-domain” as George Strawn calls it—which is still not visible due to differences about the technological key pillars. OS therefore is a need for DS, but it will take much more time to implement it than we may have expected.
Embedding Open Science in Reality
Authors: Wood John
Published: January 2021

The Open Science (OS) movement has achieved extraordinary results in very few years. In this paper I argue it is now necessary to embed OS in the wider ecosystem of research and innovation, acknowledging some of the outstanding issues that need to be resolved as it beds down into the way research is done in the future. By sticking to a purest approach to OS its impact and current momentum may be lost. Digital technologies and global connectivity have ensured that OS is here to stay and will continue to expand its influence in the future. However, OS cannot stand aloof from what is the reality of what is happening elsewhere otherwise it will do a disservice to itself and the challenges facing the world.
Constitutionalism in Poetry, Poetry in Constitutionalism: Muḥammad Ḥāfiẓ Ibrāhīm’s Imagining of Contemporary Constitutional Movements
Authors: Gösken Urs
Published: January 2021

This paper focuses on the sociocultural and historical context in which the Egyptian poet Muḥammad Ḥāfiẓ Ibrāhīm (c. 1872–1932) represented contemporary constitutional movements in the Muslim world, with special emphasis on developments in the Ottoman Empire and in late nineteenth- to early twentieth-century Egypt – back then, at least nominally, still a part of it – and extending to Iran’s Constitutional Revolution. References in Ḥāfiẓ Ibrāhīm’s poetry to constitutionalism in Japan will also be discussed in order to point out that the poet, while closely following constitutional movements in the Ottoman Empire and in Iran, in fact viewed constitutionalism as an historical process transcending geographical and cultural boundaries. Therefore, we shall also try to identify the general idea of history underlying Ḥāfiẓ Ibrāhīm’s portrayal of constitutionalism. Comparative references to constitutional poetry in Iran of that time are intended to point out the supra-regional dimension both of constitutionalism itself and of poetical modes of imagining it. Likewise, this approach is designed to make the point that constitutional poetry in the Muslim world at that time was more than just poetic commentary on constitutional movements; it was itself part of them.
La ermoza istorya de Robinzon o la mizerya: Sephardi Versions of Robinson Crusoe
Authors: Kacprzak Marta
Published: January 2021

La ermoza istorya de Robinzon o la mizerya: Sephardi Versions of Robinson CrusoeIn the second half of the 19th century the Haskalah, an intellectual movement whose objective was to educate and westernize Eastern European Jews, also reached the Sephardic communities in the Ottoman Empire. As a result, there emerged Sephardic modern secular literature, represented mainly by narrative fiction, theatre plays and press. It should be added that modern Sephardic literature is primarily based on translations or adaptations of Western novels. Among these texts we find Sephardic editions of classics of European literature, such as Romeo and Juliet by William Shakespeare, Robinson Crusoe by Daniel Defoe and Gulliver’s Travels by Jonathan Swift.I have found four different versions of Robinson Crusoe that were written in Judeo-Spanish and edited in aljamía. Two of them were published serially in Sephardi press, one in Salonica in 1881 and the other in Constantinople in 1900. The other two editions were prepared by Ben Tsiyon Taragan and published as complete versions, the first one in Jerusalem in 1897 and the second one in Constantinople in 1924. The aim of this paper is to provide a brief analysis of the Sephardic adaptations of Robinson Crusoe by Taragan. La ermoza istorya de Robinzon o la mizerya: sefardyjska wersja Robinsona CrusoeHaskala, zwana także Żydowskim Oświeceniem, to ruch intelektualny, którego celem było odrodzenie kulturowe i społeczne Żydów z EuropyWschodniej oraz ich integracja ze środowiskiem lokalnym. W drugiej połowie XIX wieku Haskala objęła także społeczność Żydów sefardyjskich zamieszkujących tereny należące do Imperium Osmańskiego, w wyniku czego powstała współczesna, świecka literatura sefardyjska reprezentowana głównie przez prozę, sztuki teatralne oraz prasę. Warto dodać, że współczesna literatura sefardyjska oparta jest przede wszystkim na przekładach lub adaptacjach powieści uważanych za klasykę literatury europejskiej, takich jak Romeo i Julia Williama Szekspira, Robinson Crusoe Daniela Defoe czy Podróże Guliwera Jonathana Swifta.W trakcie prowadzonych przeze mnie badań natrafiłam na cztery różne judeo-hiszpańskie wersje Robinsona Crusoe, które zapisane zostały alfabetem hebrajskim, tzw. pismem Rasziego. Dwie z nich ukazały się w prasie sefardyjskiej, jako powieść w odcinkach, pierwsza w Salonikach w 1881 r., a druga w Konstantynopolu w 1900 r. Pozostałe dwie, autorstwa Ben Tsiyona Taragana, zostały wydane w całości, pierwsza w Jerozolimie w 1897 r., druga zaś w Konstantynopolu w 1924 r. Celem tego artykułu jest prezentacja oraz krótka analiza sefardyjskich adaptacji Robinsona Crusoe autorstwa B. T. Taragana.
Oswajanie obcości kulturowej w przekładzie literatury dziecięcej. Przypadek Domowych duchów Dubravki Ugrešić
Authors: Ślawska Magdalena
Published: January 2021

The Domestication of Cultural Strangeness in the Translation of Children's Literature: The case of Dubravka Ugrešić's Kućni duhovi [Home Ghosts]This article is devoted to the Polish translation of Kućni duhovi [Home Ghosts], a collection of short stories by Dubravka Ugrešić, her only book addressed to the youngest readers which has been published outside Croatia. The study focuses on the issue of cultural strangeness generated mostly by proper names that appear in the stories: ghosts' names, and the names and surnames of other characters. In her translation, Dorota Jovanka Ćirlić domesticated the source text, replacing all of them with Polish equivalents. The comparative analysis presented in this article considers translation strategies she used and illustrates them with numerous examples. Oswajanie obcości kulturowej w przekładzie literatury dziecięcej. Przypadek Domowych duchów Dubravki UgrešićNiniejszy artykuł poświęcony jest przekładowi na język polski zbioru opowiadań Dubravki Ugrešić pt. Domowe duchy. Jest to jedyna książka pisarki adresowana do najmłodszych czytelników, która ukazała się poza granicami Chorwacji. Szczególna uwaga skierowana została na kwestię obcości kulturowej, którą w książce Ugrešić generują przede wszystkim nazwy własne (nazwy duchów, imiona i nazwiska pozostałych bohaterów). Dorota Jovanka Ćirlić, autorka przekładu, dokonała udomowienia tekstu źródłowego, zastępując wszystkie nazwy własne, pojawiające się w oryginale, polskimi ekwiwalentami. Zastosowane przez tłumaczkę strategie translatorskie zostały omówione oraz zilustrowane licznymi przykładami w toku analizy porównawczej.
„Ani kapłani, ani błaźni”. Odsłony zwrotu postsekularnego w antropologii
Authors: Lubańska Magdalena
Published: January 2021

Neither Priests nor Clowns: Attitudes Towards the Postsecular Turn in Anthropology The article discusses the issue of the postsecular turn in contemporary anthropology, taking into account the cultural processes involved in its emergence. The author attempts to identify research areas and issues worthy of exploring within this turn, and at the same time she considers the bound­ary conditions for its usefulness in scientific research. Referring to the recent anthropological literature on this topic, the author distinguishes two leading epistemological attitudes involved in this turn: the one that acknowledges the supernatural dimension of revelation and the one that sees it as a social fact. Both are heterogenous and each sees the relationship between anthropology and theology differently. Discussing some anthropological views in this regard, the author aims to revive the dialogue between researchers from various social and human sciences representing the postsecular turn. On the one hand, this dialogue can initiate new paths of mutual inspiration and co-thinking; on the other hand, it may lead to more conscious distinctions between different varieties of postsecular reflection. „Ani kapłani, ani błaźni”. Odsłony zwrotu postsekularnego w antropologiiCelem artykułu jest refleksja nad specyfiką zwrotu postsekularnego we współczesnej antropologii, uwzględniająca jego uwarunkowania społeczno-kulturowe oraz związane z nim postawy epistemologiczne. Autorka próbuje wskazać obszary badań i zagadnienia, które powinny być przedmiotem eksploracji tego zwrotu, a zarazem określić warunki brzegowe wykorzystywania wypracowanych na jego gruncie narzędzi analitycznych w badaniach nauko­wych. Odnosząc się do najnowszej literatury przedmiotu, autorka wyróżnia w antropologii dwie wiodące postawy epistemologiczne zaangażowane w ów zwrot: uznające rzeczywistość objawienia oraz odrzucające taką możliwość (naturalistyczne). Dostrzega, że w ich ramach wysuwane są różnorakie pomysły na to, jak mogłaby wyglądać i czemu służyć kooperacja antropologii z teologią. Prezentując antropologiczne odsłony owego zwrotu, tekst ma na celu ożywienie dialogu między reprezentującymi go badaczami uprawiającymi różne nauki huma­nistyczne i społeczne. Dialog ten z jednej strony może zainicjować nowe ścieżki wzajemnych inspiracji i współmyślenia, z drugiej zaś doprowadzić do bardziej świadomych dystynkcji między różnymi wariantami tego zwrotu.