bluuebunny/crossref_metadata_2025 huggingface dataset:
Enrique Maluku: Sang Petualang Manise dari Kepulauan Rempah
Authors: Zoe Toby , Dyaksa Velmi Dian Dana , Rabani La Ode
Published: May 2024

Reading this novel stimulates curiosity about maritime history and culture. Through the reader's point of view, reading this book makes us feel as if we are little Enrique who is being told and taught by Datuk Harun Abbas about the story of his adventure in a distant land. Appreciation to the author of the novel Clavis Mundi, especially Reinhard Tawas, who brought this topic to the surface and introduced the figure of Enrique in the stage of maritime history not only of the Malay world but also of world maritime history. In the end, Enrique's confession is immortalized in the following stanza “Moluccas, su majestad. And I am not a slave [I am Moluccan, your majesty. And I am not a slave].
History Education as an Effort to Internalize Civic Knowledge: A Case Study at an Islamic-Based Private Senior High School in Malang City
Authors: Shorunnuha Inti , Widiadi Aditya Nugroho , Hudiyanto R. Reza
Published: May 2024

This research aims to understand the process and efforts of internalizing civic knowledge (wawasan kebangsaan) in history learning, identify emerging obstacles, and evaluate the implications of such internalization. This study employs a descriptive qualitative approach. Data collection was carried out through observation, interviews, and documentation. This research data was analyzed using Miles and Huberman’s descriptive data analysis. The findings of the study indicate that: (1) the process of history learning that internalizes civic knowledge involves a series of planning, implementation, and evaluation activities; (2) teachers undergo a series of processes for internalizing civic knowledge, such as value transformation, value transaction, and trans-internalization of values; (3) obstacles and solutions for internalizing civic knowledge through history learning can be seen from the factors of the teachers themselves, the learners, and the implementation of the learning process; (4) the internalization of civic knowledge through history learning has a greater impact on national understanding compared to national pride and national attitudes.
HUBUNGAN PENGETAHUAN OBAT BAHAN ALAM DAUN KATUK (Sauropus Androgynus (L) Merr) UNTUK PENYAKIT SINDROM METABOLIK DAN KESEDIAAN MEMBAYAR DI KEC. PANYILEUKAN KOTA BANDUNG
Authors: Nurfitria Rizki Siti , Shinta Nilo Arya , Hartini Ni Nyoman Sri Mas
Published: May 2024

Daun katuk merupakan tanaman lokal Asia yang digunakan sebagai terapi berbagai penyakit. Pemanfaatan tumbuhan sebagai obat bahan alam terbukti lebih terjamin, namun yang menjadi permasalahan adalah kurangnya pengetahuan tentang daun katuk yang biasa digunakan sebagai ramuan obat-obatan bahan alam dan bagaimana pemanfaatannya sebagai antihipertensi, antidiabetes, antiinflamasi, antioksidan, dan pelancar Air Susu Ibu (ASI). Penelitian ini bertujuan untuk mengetahui pengetahuan dan kesediaan membayar masyarakat terhadap penggunaan produk obat bahan alam daun katuk sebagai pengobatan penyakit sindrom metabolik. Metode yang digunakan pada penelitian ini yaitu observasional dengan pendekatan cross sectional. Data yang digunakan berupa data primer dengan menggunakan kuesioner yang sudah diuji validitas dan reliabilitasnya. Sampel pada penelitian ini yaitu pasien Puskesmas Panyileukan yang memiliki penyakit sindrom metabolik sebanyak 120 responden. Data dianalisis secara kualitatif dan kuantitatif menggunakan uji Rank Spearman dengan aplikasi SPPS versi 22. Hasil penelitian menunjukkan bahwa pengetahuan masyarakat tentang obat bahan alam daun katuk termasuk kategori baik (86,75%), rata-rata nilai Willingness to Pay (WTP) produk obat bahan alam daun katuk untuk penyakit sindrom metabolic di Puskesmas Panyileukan yaitu sebesar Rp36.175,00. Hasil uji bivariat menunjukkan tidak terdapat hubungan yang bermakna antara tingkat pengetahuan dan kesediaan membayar dengan nilai signifikasi 0,688 (p > 0,05).
FORMULASI DAN STABILITAS MUTU FISIK SEDIAAN GEL EKSTRAK DAUN BINAHONG (Anredera cordifolia (Ten.) Steenis) DENGAN VARIASI KONSENTRASI CARBOPOL SEBAGAI GELLING AGENT
Authors: Lestari Tri Puji
Published: May 2024

Tanaman daun binahong (Anredera corfolia (Ten.) Steenis) memiliki banyak manfaat dalam bidang kesehatan karena mengandung berbagai macam senyawa metabolit sekunder antara lain alkaloid, flavonoid, terpenoid, dan antosianin yang terbukti efektif sebagai antiinflamasi, antibakteri, dan antimikroba. Memformulasikan ekstrak daun binahong (Anredera corfolia (Ten.) Steenis) dengan menggunakan gelling agent Carbopol dan di uji kestabilan mutu fisik sediaan adalah merupakan tujuan dari penelitian ini. Uji mutu fisik yang di lakukan antaralain  organoleptis, homogenitas, derajat keasaman (pH), daya sebar, daya lekat, viskositas dan  stabilitas fisik dengan metode cycling test. Gel diformulasikan menjadi 3 formula dengan variasi gelling agent Carbopol 0,5%, 1,5% dan 2%. Hasil penelitian menunjukkan bahwa penggunaan  Carbopol sebagai gelling agent pada formula 1, 2 dan 3 memberikan hasil uji mutu fisik yang memenuhi syarat untuk parameter pH, daya sebar, daya lekat, viskositas organoleptis dan homogenitas. Pengujian kestabilan fisik sediaan gel pada ketiga formulasi menunjukkan hasil yang stabil dan tidak ada perubahan yang signifikan secara pengamatan kestabilan fisik sebelum dan sesudah perubahan temperatur yang ditunjukkan dari hasil uji statistik P>0.05,
Kata kunci Mutu Fisik, Stabilitas , Ekstrak Binahong, Gel
Program Pengendalian Tikus Terpadu Padi Sawah pada Daerah Endemis Memanfaatkan Kearifan Lokal
Authors: Fauzana Hafiz , Nelvia Nelvia , Rustam Rusli , Effendi Arman , Susilawati Susilawati , Yulia Arnis En , Hamid Imam Ramadhan , Rahmadini Aulia , El Sahira Resi
Published: May 2024

Tanaman padi merupakan komoditi utama di Desa Empat Balai. Pada tahun 2022, dilaporkan serangan tikus sawah menyerang padi sawah di Kecamatan Kuok hingga menyebabkan kerusakan seluas 1 – 4 ha. Solusi permasalah­an ini adalah dilakukannya program pengabdian masyarakat dengan memberi­kan penyuluhan dan praktik pengendalian hama tikus terpadu dengan kearifan lokal oleh tim KKN Universitas Riau. Tujuan kegiatan pengabdian ini adalah me­lakukan penyuluhan, meluruskan pemahaman petani, melakukan pengen­dal­ian hama tikus dengan memanfaatkan kearifan lokal. Metode yang diguna­­kan meliputi survei, konsolidasi, penyuluhan, dan praktik lapangan. Kegiatan penyuluhan menjelaskan bioekologi tikus dan pengendalian yang tepat untuk mengatasi permasalahan serangan hama tikus. Kegiatan praktik lapangan meliputi teknik gropyokan, pengaplikasian emposan, dan pema­sang­an perangkap bambu. Kegiatan pengabdian ini berhasil dilaksanakan dengan lancar dengan melibatkan petani yang responsif. Hasil kegiatan penyuluhan menunjukkan peningkatan pemahaman dan keterampilan petani dalam pengendalian hama tikus kisaran 55-60%.
Pengendalian Hama Tikus Sawah Berbasis Hayati dengan Burung Hantu Tyto Alba di Desa Sumberjaya, Kecamatan Tempuran, Kabupaten Karawang
Authors: Afifah Lutfi , Saputro Nurcahyo W. , Adhi Satriyo R. , Enri Ultach
Published: May 2024

Tikus merupakan salah satu hama utama yang menyerang pertanaman padi di Desa Sumberjaya, Kecamatan Tempuran, Kabupaten Karawang. Pengen­dalian yang ramah lingkungan dapat menggunakan agens biologis burung hantu Tyto alba. Tujuan dari pengabdian masyarakat ini adalah untuk men­sosialisasikan dan memberi pelatihan kepada kelompok tani di Desa Sumber­jaya untuk bisa membuat dan melestarikan pengendalian berbasis hayati dengan menggunakan burung hantu untuk pengendalian tikus sawah. Kegiatan pengabdian masyarakat mitra nya yaitu kelompok tani Kedung Jaya, Desa Sumberjaya, Kecamatan Tempuran. Hasil dalam kegiatan peng­abdi­an masyarakat ini adalah 80% petani mampu membuat rubuha dan mampu melakukan konservasi musuh alami dengan penanaman refugia. T. alba datang secara alami dan mempergunakan sarang buatan tersebut sebagai tempat pemantauan tikus di areal persawahan. Rubuha yang dibuat oleh tim pengabdian masyarakat bersama dengan petani berjumlah satu rubuha, dengan adanya rubuha contoh tersebut petani mendapatkan pe­nge­tahuan untuk bisa membuat rubuha secara mandiri di Desa Sumberjaya. Adanya rubuha sebagai pengendali hama tikus dan penggunaan refugia untuk konservasi musuh alami menjadikan contoh bagi kelompok tani lain di Desa Sumberjaya untuk bisa mengendalikan hama secara ramah lingkungan.
Effects of Supplemental Diet during Breeding on Fertility, Litter Size, Survival Rate, and Weaning Weight in Mice (Mus musculus)
Authors: Wong Raymond K , Carriero Samantha J , Wadsworth Benjamin C , Raiciulescu Sorana , Field Amy E , Cadieux Christena L
Published: May 2024

The addition of supplemental diets to laboratory animals, specifically rodents, is a common practice for the provision of additional nutritional support. We set out to investigate whether the use of commercially available supplemental diets during breeding affected fertility rate, litter size, pup health, and pup survival. Genetically modified female breeding mice with a C57BL/6 background were divided into 3 groups (n = 16 per group) that received standard rodent chow alone or standard rodent chow with one of 2 commercially available supplemental diets: Love Mash (Bio-Serv) extruded pellet or Nutra-Gel (Bio-Serv) diet gel. Male and female mice began receiving the supplemental diet 1 wk before being paired with a partner of the same supplemental group. The mice were allowed to breed for 1 wk before separation from the male. The dams were continued on the diet until all pups were weaned. Overall, breeding dams supplemented with the Love Mash diet experienced significantly greater reproductive success rates and pup survivability compared with the standard diet control group. Dams supplemented with either of the 2 supplemental diets supported significantly larger litters compared with the standard diet control group. Furthermore, Love Mash supplemented diet groups produced significantly larger pups compared with the Nutra-Gel supplemented groups. This study demonstrates that supplemental diets given 1 wk before breeding and continued throughout gestation, parturition, and weaning significantly improved reproductive success, increased litter sizes, and supported pup health and survival.
THE ROLE OF OPEN-AIR CALVARIES IN THE CONTEXT OF LANDSCAPE HERITAGE PROTECTION OF THE EASTERN SUDETES
Authors:   Department of Regional Geography and Tourism, Institute of Geography and Regional Development Wrocław University, Wrocław, Poland, ŁACH Janusz , MAREK Aneta ,   epartment of Regional Geography and Tourism, Institute of Geography and Regional Development Wrocław University, Wrocław, Poland
Published: May 2024

The article concerns the meaning and landscape functions of Small Calvaries located in the Eastern Sudetes in the border area of the Czech Republic and Poland. The publication aims to indicate the main typological features of this type of calvary, taking into account the current behaviour of residents having a common sarcastic heritage. Due to the subject, interdisciplinary research was undertaken in the direction of valorization as well as environmental interviews. The use of geosociological methodology made it possible to assess the landscape in terms of its contemporary functions and potential threats. The research allowed us to distinguish two types of landscape layouts: elliptical and linear of a historical nature, and modern, mainly linear. Sociological research showed the attitude of local communities to the sacred heritage in the Eastern Sudetes.
Needle-free, Novel Fossa Ovalis Puncture with Percutaneous Transluminal Coronary Angioplasty Guidewire and Microcatheter in Pigs and a Human with an Extremely Tortuous Inferior Vena Cava
Authors: Wang Guang-Xia , Luo Hong , Jia Feng-Peng , Li Run-Tu , He Quan , Qin Chun-Chang
Published: May 2024

Background: Transseptal puncture (TSP) performed with the Brockenbrough (BRK) needle is technically demanding and carries potential risks. The back end of the percutaneous transluminal coronary angioplasty (PTCA) guidewire is blunt and flexible, with good support, it can puncture the right ventricle-free wall, which is thicker than the atrial-septum. The guidewire is thin and easy to manipulate. This study evaluated the performance of TSP with a PTCA guidewire and microcatheter without a needle. Methods: The back end of a PTCA guidewire was advanced into the Tiger (TIG) catheter, within the SL1 sheath, to puncture the fossa ovalis (FO) under fluoroscopy. Subsequently, the microcatheter was inserted into the left atrium (LA) above the guidewire, and the front end of the guidewire was exchanged in the LA. After the puncture site was confirmed by contrast, the TIG catheter and a 0.032 inch wire were advanced into the LA. Finally, the sheath, with the dilator, was advanced over the wire into the LA. The safety margin of this method was tested in a pig model. Results: The puncture was successful in all seven pigs tested with a puncture-to-sheath entry time of <20 minutes and no procedure-related complications. The method was successfully used to perform a difficult TSP in a patient with an extremely tortuous inferior vena cava, in whom puncture with a BRK needle had repeatedly failed. Conclusions: Cardiologists may use the PTCA guidewire and microcatheter as an alternative to the needle while performing TSP in special conditions, such as an extremely tortuous inferior vena cava.
Increased Secreted Frizzled-Related Protein 2 in Hypertension-Induced Left Ventricular Remodeling
Authors: Cao Mengying , Jiang Xueli , Wang Xiaolin , Gao Pan , Zou Yunzeng
Published: May 2024

Background: Secreted frizzled-related protein 2 (sFRP2) is involved in various cardiovascular diseases. However, its relevance in left ventricular (LV) remodeling in patients with hypertension (HTN) is obscure. Methods: In this study, 196 patients with HTN were included, 59 with echocardiographic LV remodeling. A total of 100 healthy subjects served as normal controls. The serum-sFRP2 level was measured by enzyme-linked immunosorbent assay (ELISA). Data were collected from medical records for baseline characteristics, biochemistry tests, and echocardiography. Receiver operating characteristic (ROC) curves were used to assess the distinguishing value of sFRP2 for LV remodeling in patients with HTN. Spearman rank correlation analysis was utilized to identify factors correlated with sFRP2. Cardiac sFRP2 was determined by Western blot and quantitative polymerase chain reaction (qPCR). Results: The level of serum-sFRP2 was higher in HTN patients with echocardiographic LV remodeling than their non-remodeling counterparts. ROC analysis showed that the area under the curve (AUC) for sFRP2 in distinguishing echocardiographic LV remodeling in HTN patients was 0.791 (95% confidence interval (CI): 0.714–0.869). The sFRP2 was negatively correlated with LV dimension and positively correlated with relative wall thickness (RWT). The expression of sFRP2 was higher in hypertrophic hearts, which could be reversed by myricetin. Conclusions: The serum level and cardiac sFRP2 increased in the setting of LV remodeling and decreased by myricetin. Serum sFRP2 may be a promising distinguishing factor for LV remodeling in HTN patients.
Global music discoveries reveal cultural shifts during the war in Ukraine
Authors: Lee Harin , Anglada-Tort Manuel , Sobchuk Oleg , van Rijn Pol , Schönwiesner Marc , Tchernichovski Ofer , Park Minsu , Jacoby Nori
Published: May 2024

Collective engagement with culture including music and the arts can trace societal changes associated with acute disruptions, such as pandemics, political movements, and wars. Can the daily shared experiences of culture reveal deep and long lasting societal impacts of disturbances? We collected longitudinal data of 12.8 million music discoveries via Shazam across 1,423 cities and 53 countries, relating them to the onset of Russia’s invasion of Ukraine in 2022. Among post-Soviet countries, results revealed cascades of societal disintegration that rapidly escalated during the invasion. Initially similar music discoveries across countries broke down into distinct clusters that persisted over months. Cultural shifts were asymmetric: Ukraine saw a stark rise in the discovery of local, patriotic music, while Russia experienced a moderate decrease in their local music. At the city-level, socio-cultural values predicted subnational changes in music discovery inflicted by the war, bringing to surface latent variations within Ukraine and Russia. Interestingly, in Belarus, despite their political alliance with Russia, discoveries of Russian music decreased while Ukrainian music increased, suggesting undercurrents and resistance. Our work provides insights into the interactions between culture and society, revealing the pathways through which societal disruptions imprint the evolution of culture.
The P2 component reveals the early perception of varied hues of colors differs between art majors and non-art major
Authors: SONG LITING
Published: May 2024

The study investigating whether there are different perception cognitive processes in varied color hues between art and non-art groups remains unknow. The study aims to investigate how different color hues affect cognitive perception. Participants, divided into art (n=22) and non-art (n=22) groups, completed tasks using cool, warm, and neutral hues while their EEG and behavioral data were recorded. The behavioral findings indicated that participants from both groups consistently rated the emotional valence of warmer colors higher than that of cool or neutral hues. The event-related potentials results revealed that warm colors elicited larger P3 amplitude than the other two hues for both groups. Additionally, there was a significant interaction effect between group and hue for the P2 components. The P2 amplitudes for the three hues varied significantly for the non-art group, but not for the art group. Decoding analysis revealed that both the art and non-art groups showed significant difference between the three stimuli using permutesion test in the P2 component time-window. The t-test also showed that the decoding accuracies for the art and non-art groups were significant difference during the time window of P2 component. The pattern of findings in this study indicated that warm and cool colors induced stronger attention than neutral hues, with warm colors being the most positive in terms of emotional appraisal, and the early color perception of the art group may differ from the non-art group.
Semantic Interference in Blocked Picture Naming: Does It Become Cumulative with Large Local Response Sets?
Authors: Wöhner Stefan , Jescheniak Jörg D.
Published: May 2024

The naming of a picture (e.g., of a horse) is delayed if the speaker has recently named one or more semantically related pictures (e.g., of a sheep or a cow). Such interference has been found both when large numbers of pictures (more than 100) are named only once (continuous naming) and when small subsets of pictures (four to six) are named repeatedly (blocked-cyclic naming). The effects have been attributed to an adaptive learning mechanism that incrementally changes the connection weights between semantic and lexical representations across naming episodes (Oppenheim et al., 2010). However, interference shows a different development in the tasks: it is cumulative in continuous naming and non-cumulative in blocked-cyclic naming. It has been argued that the use of small local response sets in blocked naming, which are easily identified and stored in working memory, introduces an additional process (e.g., a top-down bias) that constrains semantic interference. We reasoned that such a process should be less likely to be effective, and thus interference should become cumulative, as the local response sets become larger and are less easily identified. We conducted a standard blocked-cyclic naming experiment and a blocked-interleaved naming variant thereof with local response sets of 10 and 19 items, respectively. In blocked-cyclic naming, we found that interference increased from repetition 1 to repetition 3 but remained constant thereafter which was also partly confirmed on a single trial basis. In blocked-interleaved naming, interference remained constant across repetitions. We discuss the implications of our findings.
Psychological reactance to system-level policies before and after their implementation
Authors: Granulo Armin , Fuchs Christoph , Böhm Robert
Published: May 2024

Governments need to develop and implement effective policies to address pressing societal problems of our time, such as climate change and global pandemics. While some policies focus on changing individual thoughts and behaviors (e.g., informational interventions, behavioral nudges), others involve systemic changes (e.g., car bans, vaccination mandates). Policymakers may use system-level policies to achieve socially desirable outcomes, yet often refrain from doing so because they anticipate public opposition. In this article, we propose that people’s psychological reactance driving this opposition is a transient phenomenon that dissipates once system-level policies are in place. Using secondary survey data (N = 49,674) and experimental data (six studies; N = 4,628; all preregistered), we document that psychological reactance to system-level policies is greater when they are planned (ex ante implementation) than when they are already implemented (ex post implementation). We further demonstrate that this effect can be observed across various intervention contexts and provide insights into its underlying psychological mechanisms. Specifically, ex ante versus ex post the system-level policy’s implementation, individuals focus more on the transition-induced personal losses than on the prospective societal outcome gains. In line with this perspective, we show that the decline in reactance to system-level policies after their implementation is mediated and moderated by the salience of personal losses, and that the initial reactance to such policies is mitigated by the salience of societal gains. These findings suggest that the public’s negative reactions to system-level policies are more transient than previously thought and can help policymakers design effective interventions.
Myth as Model: Group-Level Interpretive Frameworks
Authors: Moser Cody James
Published: May 2024

I argue that while recruitment might explain some of the design features of historical myths, origin myths in general more importantly provide shared narrative frameworks for aligning and coordinating members of a group. Furthermore, by providing in-group members with shared frameworks for interfacing with the world, the contents of myths likely facilitate the selection of belief systems at the group-level.
Rwanda's Peacebuilding Fragility: Voices from the Rwandan Diaspora in Kenya
Authors: Musafiri Elly , Gona George , Ombongi Kenneth
Published: May 2024

This article examines the motivations that drive Rwandan diasporans in Kenya to oppose their country's peacebuilding efforts. As findings indicate, many Rwandan Hutu and Tutsi diasporans in Kenya oppose Rwanda's post-genocide peacebuilding process mainly due to the authoritarian governance of the current regime. This type of governance is characterized by silencing critics with violence, militarizing the peacebuilding process, and unequal socio-economic development, among others. Subsequently, there is little space for Rwandan diasporans in Kenya, and Rwandans in general, to participate in rebuilding their country towards a sustainable future.
The Methodology of Ali Shari’ati: A Comparison with Durkheim’s and Weber’s Sociology of Religion
Authors: Mushtaq Ahmed Younus Ahmed , Zulqernain Haider Subhani
Published: May 2024

Ali Shari’ati was an ideologue par excellence, who through his writings and fiery speeches was able to attract the young intelligentsia of Iran and prepare them for the cataclysmic movement that took place in 1979. The methodology adopted by Ali Shari’ati in his study of religion was different from two classical sociologists. The objective of this paper is to highlight how Ali Shari’ati differed in his sociology of religion from sociologists, such as Emilé Durkheim and Max Weber. Through thematic content analysis, the works of the authors were reviewed to understand their methodology. The findings of this paper outline the methodology adopted by Ali Shari’ati, which was different, both, in its approach and the tools used to analyze religion. Though there was a shift in methodology when compared to classical sociologists, this paper agrees that the methodology of Ali Shari’ati was the best suited to study a deeply religious Asian society such as Iran.
Jak oszukują vintedzianki, czyli prawo karne wobec wybranych przejawów przestępczej aktywności użytkowników platformy sprzedażowej Vinted
Authors: Wojewoda Ewelina
Published: May 2024

Vinted is a marketplace which allows its users to buy and sell certain items from and to other people. The online second-hand platform has been operating in Poland since as early as 2013. Being able to conclude online transactions through a popular platform, accounting for the nature of those transactions, provides, despite many advantages, an opportunity for many abuses. There are more and more reports of fraud on the part of Vinted users, both buyers and sellers. What is also surprising, is the creativity and evolution of the methods which the users of this platform follow to commit criminal offences. The criminal activity of Vinted users is a novelty among crimes against property, which means that this subject-matter is yet to be explored at all in criminal legal literature.
The Effect of Computerized Cognitive Training, with and without Exercise, on Cortical Volume and Thickness and Its Association with Gait Speed in Older Adults: A Secondary Analysis of a Randomized Controlled Trial
Authors: Stein Ryan G. , Ten Brinke Lisanne F. , Boa Sorte Silva Nárlon C. , Hsu Chun Liang , Handy Todd C. , Hsiung Ging-Yuek R. , Liu-Ambrose Teresa
Published: May 2024

Background:

Slower walking is associated with changes in cortical volume and thickness. Computerized cognitive training (CCT) and exercise improve cortical volume and thickness and thus, may promote gait speed. Slowing of gait is predictive of Alzheimer’s disease.

Objective:

To examine: 1) the effect of CCT, with or without physical exercise, on cortical volume and thickness and; 2) the association of changes in cortical volume and thickness with changes in gait speed.

Methods:

A subset of 124 adults ( n = 53), aged 65–85 years, enrolled in an 8-week randomized controlled trial and completed T1-weighted MRI and 4-meter walk at baseline and 8 weeks. Participants were randomized to: 1) active control (BAT; n = 19); 2) CCT ( n = 17); or 3) CCT preceded by exercise (Ex-CCT; n = 17). Change in cortical volume and thickness were assessed and compared across all groups using Freesurfer.

RESULTS:

BAT versus CCT increased left rostral middle frontal gyrus volume ( p  = 0.027) and superior temporal gyrus thickness ( p = 0.039). Ex-CCT versus CCT increased left cuneus thickness ( p < 0.001) and right post central gyrus thickness ( p = 0.005), and volume ( p < 0.001). Ex-CCT versus BAT increased left ( p = 0.001) and right ( p = 0.020) superior parietal gyri thickness. There were no significant between-group differences in gait speed ( p > 0.175). Increased left superior parietal volume ( p = 0.036, r = 0.340) and thickness ( p = 0.002, r = 0.348), right post central volume ( p = .017, r = 0.341) and thickness ( p = 0.001, r = 0.348), left banks of superior temporal sulcus thickness ( p = 0.002, r = 0.356), and left precuneus thickness ( p < 0.001, r = 0.346) were associated with increased gait speed.

CONCLUSIONS:

CCT with physical exercise, but not CCT alone, improves cortical volume and thickness in older adults. These changes may contribute to the maintenance of gait speed in aging.
Association Between Oral Malodor and Dementia: An 11-Year Follow-Up Study in Japan
Authors: Ho Duc Sy Minh , Zaitsu Takashi , Ihira Hikaru , Iwasaki Masanori , Yoshihara Akihiro , Suzuki Seitaro , Inoue Manami , Yamagishi Kazumasa , Yasuda Nobufumi , Aida Jun , Shinozaki Tomohiro , Goto Atsuhi , Tsugane Shoichiro , Sawada Norie
Published: May 2024

Background:

As infrequent social interaction is a potential risk of dementia, oral malodor may increase the risk of dementia, including Alzheimer’s disease.

Objective:

This study investigated the association between malodor and dementia.

Methods:

We used the Japan Public Health Center-based Prospective Study data obtained at Yokote City. A total of 1,493 individuals aged 56 to 75 years underwent a dental examination and self-reported survey from May 2005 to January 2006. Follow-up for the onset of dementia was conducted using long-term care insurance data from 2006 to 2016. Hazard ratios of oral malodor on dementia were estimated by the Cox proportional hazards model. The inverse probability-weighted Cox model was used as a sensitivity analysis.

Results:

The study comprised 1493 participants (53.6% women) with a mean age of 65.6 (SD = 5.8) years old; at the end of the follow-up, 6.4% ( n = 96) developed dementia, and the percentage was 20.7 in severe malodor group. Throughout 15274.133 person-years of follow-up, the average incidence rate for the onset of dementia per 1000 person-years was 6.29. The highest incidence rate was seen in participants with severe malodor (22.4 per 1000 person-years). After adjusting for confounders, compared to those with no malodor, there was a 3.8 (95% confidence interval: 1.5 to 9.4) times greater hazard of developing dementia in participants with severe malodor. The inverse probability weighted Cox model confirmed the same trend with an adjusted marginal hazard ratio of 4.4 (1.2 to 16.4).

CONCLUSIONS:

A significant association between oral malodor and the onset of dementia exists.
In-silico prediction of anti-breast cancer activity of ginger (Zingiber officinale) using machine learning techniques
Authors: Gondokesumo Marisca Evalina , Rasyak Muhammad Rezki
Published: May 2024

INTRODUCTION: Indonesian civilization extensively uses traditional medicine to cure illnesses and preserve health. The lack of knowledge on the security and efficacy of medicinal plants is still a significant concern. Although the precise chemicals responsible for this impact are unknown, ginger is a common medicinal plant in Southeast Asia that may have anticancer qualities. METHOD: Using data from Dudedocking, a machine-learning model was created to predict possible breast anticancer chemicals from ginger. The model was used to forecast substances that block KIT and MAPK2 proteins, essential elements in breast cancer. RESULT: Beta-carotene, 5-Hydroxy-74′-dimethoxyflavone, [12]-Shogaol, Isogingerenone B, curcumin, Trans-[10]-Shogaol, Gingerenone A, Dihydrocurcumin, and demethoxycurcumin were all superior to the reference ligand for MAPK2, according to molecular docking studies. Lycopene, [8]-Shogaol, [6]-Shogaol, and [1]-Paradol exhibited low toxicity and no Lipinski violations, but beta carotene had toxic predictions and Lipinski violations. It was anticipated that all three substances would have anticarcinogenic qualities. CONCLUSION: Overall, this study shows the value of machine learning in drug development and offers insightful information on possible anticancer chemicals from ginger.
A benchmark dataset for the retail multiskilled personnel planning under uncertain demand
Authors: Henao César Augusto , Porto Andrés Felipe , González Virginia I.
Published: May 2024

In this data article, we present and describe datasets designed to address multiskilled personnel assignment problems (MPAP) under uncertain demand. The data article introduces simulated datasets and a real dataset obtained from a retail store in Chile. The real dataset provides details on the structure of the store, including the number of departments and workers, the type of labor contract, the cost parameter values, and the average demand across all store departments. The simulated datasets, consisting of 18 categorized text files, were generated through Monte Carlo simulation to encapsulate information about the stochastic demand for store departments. These text files are classified based on: (i) type of sample (in-sample or out-of-sample), (ii) type of truncation method (zero-truncated or percentile-truncated), and (iii) demand coefficient of variation (5%, 10%, 20%, 30%, 40%, 50%). This categorization allows academics and practitioners to select the scenarios that meet with their specific research or application needs, increasing the flexibility and applicability of the datasets. In addition, researchers and practitioners can use these comprehensive real and simulated datasets to benchmark the performance of diverse optimization methods under uncertain demand, thereby ensuring robust multiskilling levels for similar MPAPs. Furthermore, we offer an Excel workbook with the capability to generate up to 10,000 demand scenarios for varying coefficients of variation in demand.
Validity and reliability of the Valkyria Trainer Balance® portable force platform in its isometric mode
Authors: Huerta Ojeda Álvaro , Beltrán-Inostroza Rodrigo , Yeomans-Cabrera María-Mercedes , Torres-Banduc Maximiliano
Published: May 2024

BACKGROUND:

Isometric maximal voluntary force (IMVF) is essential for individuals’ health and physical performance. Therefore, there is a need for valid and reliable devices to assess IMVF.

OBJECTIVE:

To determine the validity and reliability of the Valkyria Trainer Balance® portable force platform in its isometric mode.

METHODS:

Fifty-eight physically healthy individuals (30 men and 28 women) participated in the study. A repeated measures design was used to compare the inter-day test-retest reliability of peak force. The validity of the Valkyria Trainer Balance® force platform was determined by comparing the peak force with the ArtOficio® force platform. The analysis consisted of the intraclass correlation coefficient (ICC), standard error of measurement (SEM), and coefficient of variation (CV). A CV [Formula: see text] 10% and ICC [Formula: see text] 0.80 were considered acceptable reliability, while a [Formula: see text] 5% and ICC [Formula: see text] 0.90 were regarded as high reliability.

RESULTS:

CV the peak force showed high test-retest inter-day reliability (CV [Formula: see text] 4.3% and ICC [Formula: see text] 0.99). When comparing both force platforms, there was a 1.1% difference between the two devices.

CONCLUSIONS:

The results of this study demonstrate that the Valkyria Trainer Balance® force platform is valid and reliable for assessing IMVF in physically healthy individuals.
Apoptosis, Autophagy, and Mitophagy Genes in the CA3 Area in an Ischemic Model of Alzheimer’s Disease with 2-Year Survival
Authors: Pluta Ryszard , Bogucka-Kocka Anna , Bogucki Jacek , Kocki Janusz , Czuczwar Stanisław J.
Published: May 2024

Background:

Currently, no evidence exists on the expression of apoptosis ( CASP3), autophagy ( BECN1), and mitophagy ( BNIP3) genes in the CA3 area after ischemia with long-term survival.

Objective:

The goal of the paper was to study changes in above genes expression in CA3 area after ischemia in the period of 6–24 months.

Methods:

In this study, using quantitative RT-PCR, we present the expression of genes associated with neuronal death in a rat ischemic model of Alzheimer’s disease.

Results:

First time, we demonstrated overexpression of the CASP3 gene in CA3 area after ischemia with survival ranging from 0.5 to 2 years. Overexpression of the CASP3 gene was accompanied by a decrease in the activity level of the BECN1 and BNIP3 genes over a period of 0.5 year. Then, during 1-2 years, BNIP3 gene expression increased significantly and coincided with an increase in CASP3 gene expression. However, BECN1 gene expression was variable, increased significantly at 1 and 2 years and was below control values 1.5 years post-ischemia.

Conclusions:

Our observations suggest that ischemia with long-term survival induces neuronal death in CA3 through activation of caspase 3 in cooperation with the pro-apoptotic gene BNIP3. This study also suggests that the BNIP3 gene regulates caspase-independent pyramidal neuronal death post-ischemia. Thus, caspase-dependent and -independent death of neuronal cells occur post-ischemia in the CA3 area. Our data suggest new role of the BNIP3 gene in the regulation of post-ischemic neuronal death in CA3. This suggests the involvement of the BNIP3 together with the CASP3 in the CA3 in neuronal death post-ischemia.
Interprofessional collaboration mediates the relationship between perceived organizational learning and safety climate in hospitals: A cross-sectional study
Authors: Ishii Keiko , Fujitani Katsumi , Matsushita Hironobu
Published: May 2024

BACKGROUND:

Organizational learning (OL) and interprofessional collaboration (IPC) are said to enhance medical safety in hospitals, but the relationship between these variables has not been quantitatively tested.

OBJECTIVE:

This study examines the mediating effects of IPC on the relationship between OL and safety climate (improvement, compliance, and patient/family involvement).

METHODS:

An anonymous self-reporting questionnaire was administered to 1,495 healthcare workers from November 2021 to January 2022. The questions regarded the hospital’s safety climate, OL, and IPC. A mediation analysis using structural equation modeling was conducted to examine the mediating role of IPC on the relationship between OL and the three safety climates. The indirect effect was estimated using 2,000 bootstrap samples.

RESULTS:

Responses from 643 healthcare workers were analyzed. The direct effects of OL were 𝛽 = .74, 75 ( p < .001) on improvement and involvement and 𝛽 = 0.1 ( p > .05) on compliance. The indirect effects of IPC on improvement and involvement were 𝛽 = .14 (95%CI: .00 ∼ .06) and 𝛽 = .37 (95%CI: .04 ∼ .09), respectively.

CONCLUSION:

This study determined the mechanisms that enhance a hospital’s safety climate, demonstrating that IPC mediates the relationship between OL and improvement and patient/family involvement. However, OL and IPC are not related to compliance.
Predictive value of miR-7110-5p and miR-223-3p as biomarkers for sepsis secondary to pneumonia
Authors: Zhang Xinliang , Wang Lin , Li Mei , Dong Shimin
Published: May 2024

BACKGROUND: Investigating the secondary sepsis of pneumonia is of great significance for rapid diagnosis and early treatment of sepsis. OBJECTIVE: This study aimed to investigate the predictive value of micro ribonucleic acids (miRNA) 7110-5p and miR-223-3p in sepsis secondary to pneumonia. A miRNA microarray was used to analyze the differences in miRNA expression between patients with pneumonia and those with sepsis secondary to pneumonia. METHODS: The study included a total of 50 patients with pneumonia and 42 patients with sepsis secondary to pneumonia. Quantitative polymerase chain reaction analysis was conducted to measure the circulating miRNA expression levels in patients and assess their correlations with clinical characteristics and prognosis. In this study, nine miRNAs – hsa-miR-4689-5p, hsa-miR-4621-5p, hsa-miR-6740-5p, hsa-miR-7110-5p, hsa-miR-765, hsa-miR-940, hsa-miR-213-5p, hsa-miR-223-3p, and hsa-miR-122 – met the screening criteria of having a fold change ⩾ 2 or < 0.5; p< 0.01 indicated significant differences in the results. RESULTS: The expression levels of miR-7110-5p and miR-223-3p differed between the two patient groups, being up-regulated in the plasma of patients with sepsis secondary to pneumonia. miR-7110-5p and miR-223-3p showed higher expression levels in both patients with pneumonia and sepsis compared to healthy controls. Moreover, the receiver operating characteristic curve revealed that the areas under the curve for predicting pneumonia using miR-7110-5p were 0.781 while those for predicting sepsis secondary to pneumonia were 0.862. For miR-223-3p, the corresponding values for predicting pneumonia and sepsis secondary to pneumonia were 0.879 and 0.924, respectively. However, there were no significant differences in the levels of miR-7110-5p and miR-223-3p between the plasma of survived and deceased patients with sepsis. CONCLUSIONS: MiR-7110-5p and miR-223-3p have the potential to serve as biological indicators for predicting sepsis secondary to pneumonia.
“Ǫuantum Jump” and Their Effects on the Photo Whitening Technique
Authors: Panhoca Vitor Hugo , Zanin Fátima Antonia Aparecida , Bagnato Vanderlei Salvador
Published: May 2024

Recent research on tooth whitening aims to optimize whitening while minimizing its side effects, such as tooth hypersensitivity and damage to the soft and hard tissues of the oral cavity. Various research with methodology using colorimetric and spectrophotometric tests shows that the technique applying violet light, with a wavelength of 408 nm, produced better results than other sources normally used in tooth whitening. Scientific findings prove the results that simultaneously applying dental whitening in the office with transparent/colorless gels and violet LEDs allows the light to interact directly with the pigments, increasing the oxidation effect with the peroxide itself. So, there is a double effect: the photochemical action with the oxidation molecule with the peroxides promoting the optimization of the traditional use of chemical agents. This short communication aims to highlight the advantage of using violet light and provide more physical and chemical information about this whitening process. This is a new technique, without producing heat, roughness or sensitivity, with comfort and safety for the patient and professional. We can conclude that new studies become relevant for the evolution of this technique.
PERAN PENTING KEPEMIMPINAN TRANSFORMASIONAL DALAM PROSES PENGEMBANGAN MADRASAH
Authors: Buchori Uuh , Ma'mur Ilzamudin , Muhtarom Ali
Published: May 2024

Transformational leadership plays a crucial role in the development of madrasahs as Islamic educational institutions. This qualitative research aims to understand the significance of transformational leadership in madrasah development. Through a qualitative approach, this study explores relevant journals to gain a deeper understanding of the role of transformational leadership in madrasah development. The findings of this study indicate that transformational leadership significantly contributes to madrasah development. Transformational leaders have the ability to inspire, empower, and create a supportive work climate that fosters change and innovation in the context of education and teaching. Transformational leadership also facilitates constructive assessment and feedback, as well as continuous development of teacher competencies. It is crucial for madrasah leaders to develop effective transformational leadership skills. By doing so, madrasah leaders can create an inspirational, empowering, and motivating learning environment for teachers and students. This contributes to the overall development of madrasahs, including enhancing the quality of education, addressing challenges and issues, and improving teacher performance and student motivation.
Application of Text File Steganography on Video using Least Bit Significant (LSB) Method
Authors: Mellynda Nabila , Nasution Yusuf Ramadhan
Published: May 2024

In the era of rapid development of information technology, data security is a crucial aspect that must be considered. The transfer and storage of information involves various media, including text and video. Unfortunately, most data sent or stored tends to be vulnerable to security threats. The purpose of this research is to implement text file steganography on video using the Least Bit Significant (LSB) method that can be used to hide secret messages. The method used in this research are LSB and Waterfall development method. The results of the study concluded that the LSB algorithm can be used in the process of insertion and extraction of text messages on video, text messages in this study are text contained in a text file with the txt extension. Videos that have been inserted text messages will have an extension of mp4 and cannot be played on video file playback media, The application produced in this study can be run through a web browser application, The application in this study was built using Visual Studio Code software using the HTML and Javascript programming languages.
The Сonstruct of “Value of Health” as a Predictor of Post-Hospital Compliance in People Affected by TIA
Authors:   H.S. Kostiuk Institute of Psychology of the National Academy of Educational Sciences of Ukraine, Bondarenko Nikita
Published: May 2024

The article is devoted to the specifics of providing clinical and psychological assistance to people who, after a short-term hospitalization (5-7 days), were discharged from the hospital with a diagnosis of “transient ischemic attack” (TIA). The purpose of the study is to clarify the hierarchy of value meanings in the value system of patients who have undergone a TIA, as well as to study how exactly these values affect their attitude to taking care of their own health and, more importantly, adherence to the post-hospital outpatient self-care regimen. Research methods and techniques. Based on the main task of the research, the following diagnostic tools were used: the Mini-mult test adapted by V.P. Zaitsev; method of portrait selections by L. Sondi (MPV); questionnaire “Attitude to health” (author R. Berezovska); patient health questionnaire (Patient Health Questionnaire - PHQ-9); J. Rother’s method of diagnosing the level of subjective control (adaptation by E.F. Bazhyn, S.A. Golinkin, O.M. Etkinda); quality of life assessment questionnaire (SF-36); universal questionnaire for the quantitative assessment of adherence to treatment (QAA-25) by N.A. Nikolaev and Y.P. Skirdenko. Results and discussion. The study found that health is the leading terminal value for patients who have undergone a TIA, a happy family life is the second, and independence is the third one. At the same time, on the basis of regression analysis, the assumption about the overwhelming desirability for patients of such forms and methods of treatment, which minimizes their own efforts in order to overcome the disease, is substantiated. Conclusions. The results show that there are clearly expressed trends, with the help of which it is possible to orient oneself in the probable post-hospital behavior of the patient in relation to his own health, which in a new way raises the question of defining not so much typical, but rather individual ways of psychological approach to the patient’s personality, which corresponds to the prospects for the development of personalized medicine.