bluuebunny/crossref_metadata_2025 huggingface dataset:
Can contextual factors affect match running performance in elite youth soccer players? A case study in Brazil
Authors: Gonçalves Luiz Guilherme , Nobari Hadi , Rites Alex Ambrosio , Nakamura Fábio Yuzo , Garcia Gabriel Rodrigues , Aquino Rodrigo
Published: August 2022

This study investigated the effects of match location (i.e., home vs. away), quality of opposition (i.e., weak vs. intermediate vs. strong), and the match outcome (i.e., loss vs. draw vs. win) on match running performance of starters and non-starters young elite Brazilian soccer players. Thirty-five male outfield players were observed during the U20 Brazilian National League and were classified into starters (played ≥ 60 minutes: n = 133 individual observations) and non-starters (played < 60 minutes; n = 59 individual observations). The distance- and accelerometry-based measures were recorded during 17 matches using a global position system (10 Hz). The main results were: i) non-starters covered greater absolute sprinting distance (SPRabs: p = 0.02; Effect Size [ES] = large), SPR distance relative per minute played (SPRrel: p = 0.005; ES = very large), and high-acceleration and deceleration relative per minute played (ACC+DECrel: p < 0.001; ES = very large) in the home compared to away matches; ii) in starters, matches played against strong opponents resulted in higher values of absolute total distance in high-speed running (HSRabs) (p = 0.04; ES = very large) and high-speed running per minute played (HSRrel) (p = 0.04; ES = very large) compared to matches played against weaker opponents; iii) non-starters covered greater absolute total distance in matches against strong vs. intermediate opponents (p = 0.02; ES = very large); iv) starters (p = 0.03; ES = moderate) and non-starters (p = 0.04; ES = very large) covered greater absolute ACC+DEC distances in matches that resulted in win vs. draw. These findings suggest that match contextual factors influenced both starters and non-starters young elite soccer players. Coaches and practitioners should consider these aspects when interpreting the match running outputs and use them to inform team tactics, selection, and substitution strategies.
Abbreviations
GPS: global positioning systems. TD: total distance covered. HSR: total distance covered under high-speed running. Acc: total distance covered under high acceleration. Dec: total distance covered under high deceleration. Abs: absolute. Rel: relative. ES = effect size.
Mathematical formulation of the purchase funnel by using knowledge space theory
Authors: Lin Yung-Tzu , Chang Chuan-Yi , Cheng Shein-Yung , Lin Meng-Yun
Published: August 2022

The retail industry provides customers with goods or services. Analyzingthe purchase behavior of customers is critical for expanding thebusiness. Therefore, managing the repurchase intention of customersis crucial. A sequence of purchase behaviors by each customer constitutesa set of purchase customer journeys (purchase CJs), whichdetail purchase pathways and repurchase behaviors. Purchase CJs arethe actual retail transaction data. This study investigated purchaseCJs and proposed a purchase funnel called CJ graph (CJG) bymeasure theory and knowledge space theory with actual retail transactiondata. To achieve this objective, a customer journey block (CJB),denoting “touchpoint,” is defined as a series of purchase behaviors duringa period and used as the base of this method. Each touchpointis allotted a measurable function, named purchase measure (PM).By integrating all the CJBs of purchase CJs, the purchase measuregraph (PMG) can be constructed as the primary structure ofthe PM knowledge structure. Finally, when all CJs are coordinatizedwith CJ codes, knowledge space theory is used to develop the customerjourney graph (CJG). In this method, knowledge bases are usedas the spanning framework of the CJ knowledge space, and the filteringproperty of the purchase funnel is illustrated. Furthermore, to validate the feasibility of the proposed method, a set of two-year andone million transactions retail data generated from more than thirty-sixthousand customers was segmented by recency, frequency, and monetary(RFM) model. Thus, the corresponding PMGs and CJGs of various(12, here) customer segments are detailed, and the resultant knowledgebases of the primary purchases and secondary re-purchases are appliedto analyze and predict the customer purchase behaviors accurately.
Molecular interaction studies on thermophysical and excess properties of formamide with n-propanol
Authors: Navarkhele Aishwarya , Ambewadikar Digvijayshree , Jadhav Sujata , Navarkhele Vaijanath
Published: August 2022

Static dielectric constants at (293.15, 298.15, 303.15 K), densities and refractive indices at (293.15 K) of binary mixtures of formamide with n-propanol have been measured over the entire range of mole fractions. The variation in measured parameters with respect to temperature and composition are discussed in detail. Excess dielectric constants, Kirkwood and Bruggeman factors were estimated from experimental dielectric data to confirm molecular structure, orientation of electric dipoles, intermolecular interaction and hydrogen bonding in the binary mixtures. Excess molar volume VE, deviation in molar refraction ΔR, related thermophysical parameters, excess properties have also been estimated and analyzed. The nonlinear variation in dielectric constants, deviation in linear relation in Bruggeman factor, negative VE and ΔR suggest the presence of molecular interaction and formation of hydrogen bonds between formamide and n-propanol molecules.
Disease Burden of Prostate Cancer from 2014 to 2019: Estimation from the Global Burden of Disease Study 2019 and Medical Expenditure Panel Survey.
Authors: Li Yiyuan , Lin Shen , Lin Dong , Zhong Lixian , Wu Yajing , Xie Chen , Luo Shaohong , Huang Xiaoting , Xu Xiongwei , Weng Xiuhua
Published: August 2022

Purpose
To evaluate the disease burden of prostate cancer (PC), and assess key influencing factors associated with the disease expenditures of PC in the US.
Methods
The total deaths, incidence, prevalence, Disability-Adjusted Life Years of prostate cancer were obtained from the Global Burden of Disease Study 2019. The Medical Expenditure Panel Survey was used to estimate the healthcare expenditures and productivity loss, and to investigate the payment and utilization pattern of healthcare resources in the US. A multivariable logistic regression model was conducted on medical expenditure to assess key influencing factors for the expenditures.
Results
For patients aged 49 and above, the burden in all age groups maintain a modest increase trend over the six-year period. The estimated annual medical expenditure ranged from $24.8 to $39.2 billion from 2014 to 2019. The patients’ productivity loss is approximately $1,200 per patient per year. The top three major components of medical costs were hospital inpatient stays, prescription medicines, and office-based visits. Medicare represented the largest source of payment for survivors. In term of drug consumptions, genitourinary tract agents (57.0%) and antineoplastics (18.6%) are the primary treatment drugs for these patients. High medical expenditures were positively associated with age (p = 0.005), having private health insurance (p = 0.016), more comorbidities, currently no smoke (p = 0.001), and patients’ self-perceived in fair/poor health status (p < 0.001).
Conclusions
From 2014 to 2019, the national real-world data of PC revealed that the disease burden in the US kept increasing, which were partly associated with patient characteristics.
Identifying novel interactions of the colon-cancer related APC protein with Wnt-pathway nuclear transcription factors
Authors: Al-Thani Nayra M. , Schaefer-Ramadan Stephanie , Aleksic Jovana , Mohamoud Yasmin A. , Malek Joel A.
Published: August 2022

Background
Colon cancer is often driven by mutations of the adenomatous polyposis coli (APC) gene, an essential tumor suppressor gene of the Wnt β-catenin signaling pathway. APC and its interactions in the cytoplasm have been well studied, however various groups have also observed its presence in the nucleus. Identifying novel interactions of APC in the Wnt pathway will provide an opportunity to better understand the nuclear role of APC and ultimately identify potential cancer treatment targets.
Methods
We used the all-vs-all sequencing (AVA-Seq) method to interrogate the interactome of protein fragments spanning most of the 60 Wnt β-catenin pathway proteins. Using protein fragments identified the interacting regions between the proteins with more resolution than a full-length protein approach. Pull-down assays were used to validate a subset of these interactions.
Results
74 known and 703 novel Wnt β-catenin pathway protein-protein interactions were recovered in this study. There were 8 known and 31 novel APC protein-protein interactions. Novel interactions of APC and nuclear transcription factors TCF7, JUN, FOSL1, and SOX17 were particularly interesting and confirmed in validation assays.
Conclusions
Based on our findings of novel interactions between APC and transcription factors and previous evidence of APC localizing to the nucleus, we suggest APC may compete and repress CTNNB1. This would occur through the binding of the transcription factors (JUN, FOSL1, TCF7) to regulate the Wnt signaling pathway including through enhanced marking of CTNNB1 for degradation in the nucleus by APC binding with SOX17. Additional novel Wnt β-catenin pathway protein-protein interactions from this study could lead researchers to novel drug designs for cancer.
A novel process to reduce obstructive azoospermia recurrence after transurethral seminal vesiculoscopy
Authors: Pang Kun , Zhu Zuobin , Pan Deng , Ma Yuyang , Xu Hao , Chen Bo , Feng Harry , Han Conghui
Published: August 2022

Introduction
Transurethral seminal vesiculoscopy (TSV) is a common treatment for obstructive azoospermia but has a high rate of recurrence.
Aim
Introduce a new method involving indwelling double-J (D-J) tubes in seminal vesicles during TSV in order to reduce recurrent rate and refractory obstructive azoospermia.
Methods
A prospective study was performed to compare the effects and complications of patients treated with or without indwelling D-J tubes after TSV. General information and TSV Surgical parameters, including age, body mass index, preoperational antibiotics, history of urinary tract disease, surgical time length (STL) and complications during and after the surgery, were collected and used as baseline information. The current study compared the postoperative complications and postoperative hospital days (PHD), as well as the recurrence rate of haemospermia between the two groups.
Results
A total of 59 cases, including 28 patients who underwent treatment with indwelling D-J tubes and 31 patients who underwent treatment with the standard TSV procedure, were enrolled in this study. There was no statistically significant difference in baseline data, Intraoperative and postoperative complications and postoperative hospital days between the two groups (p > 0.05), and there was a statistically significant difference in STL and recurrence rate between the two groups (p < 0.05), the recurrence rate was lower in D-J group (21.4%) than that of control group (41.9%). This technique can effectively suppress the appearance of the first recurrence peak after TSV.
Conclusion
We introduced a new technique of indwelling D-J tubes for TSV to reduce the recurrence rate and refractory obstructive azoospermia.
A method for planning disaster risk management and calibrating disaster relief efforts: application to the 2009 and 2022 Tonga tsunamis
Authors: Thomas Bruce Enki Oscar , Roger Jean , Gunnell Yanni , Ashraf Salman
Published: August 2022

Coastal communities are highly exposed to ocean- and climate-related hazards but often lack an accurate population and infrastructure database. On January 15, 2022 and for many days thereafter, the Kingdom of Tonga was cut off from the rest of the world by a destructive tsunami associated with the Hunga Tonga Hunga Ha’apai volcanic eruption. This situation was made worse by COVID-19-related lockdowns and no precise idea of the magnitude and pattern of destruction incurred. The occurrence of such events in remote island communities highlights the need for (1) precisely knowing the distribution of residential and public buildings, and (2) evaluating what proportion of those would be vulnerable to a tsunami. A GIS-based dasymetric mapping method, previously tested in New Caledonia for assessing and calibrating population distribution at high resolution, is improved and implemented in less than a day to jointly map population clusters and critical elevation contours based on runup scenarios, and is tested against destruction patterns independently recorded in Tonga after the two recent tsunamis of 2009 and 2022. Results show that 62% of the population of Tonga lives in well-defined clusters between sea level and the 15 m elevation contour. The patterns of vulnerability thus obtained for each island of the archipelago allow exposure and potential for cumulative damage to be ranked as a function of tsunami magnitude and source-area. By relying on low-cost tools and incomplete datasets for rapid implementation in the context of natural disasters, this approach works for all types of natural hazards, is easily transferable to other insular settings, can assist in guiding emergency rescue targets, and can help to elaborate future land-use planning priorities for disaster risk reduction purposes.
Elimination of Praziquantel-Resistant Dipylidium caninum with Nitroscanate in a Mixed-Breed Dog: a Novel Application of Capsule Endoscopy
Authors: Loftus John P. , Acevedo Andrew , Bowman Dwight D. , Liotta Janice L. , Wu Timothy , Zhu Melinda
Published: August 2022

Background
Praziquantel is the drug of choice for treating Dipylidium caninum in dogs; however, resistance is possible.
Methods
Microscopy was used to identify Dipylidium spp. segments and capsule endoscopy visualized adult tapeworms within the intestinal tract.
Results
An 18-month-old spayed female terrier mix was presented due to diarrhea, hematochezia, and weight loss. The dog received appropriate anthelmintic therapy for Giardia spp., Ancylostoma spp., and Dipylidium spp. The dog’s clinical signs resolved, and elimination of Ancylostoma spp. was confirmed by subsequent fecal analysis. However, Dipylidium spp. segments were repeatedly present in the stool. Observation of the segments under light microscopy confirmed the presence of adult Dipylidium spp. Several medications, including flea treatments, praziquantel, and epsiprantel, were unsuccessful in eliminating the organism. A single dose of nitrosconate was administered and eliminated Dipylidium spp. infection in the dog.
Conclusions
Nitrosconate can be a safe and effective treatment for praziquantel-resistant dipylidiasis in dogs. The novel application of capsule endoscopy confirmed anthelmintic efficacy.
Does surgical position affect infective complications in percutaneous nephrolithotomy?
Authors: Kasap Yusuf , Senel Samet , Uzun Emre , Polat Muhammed Emin , Koudonas Antonios , Ozden Cuneyt
Published: August 2022

The downward orientation of the access sheath during supine percutaneous nephrolithotomy (PCNL) allows the faster evacuation of fluids and stone fragments. It theoretically can contribute to the reduction of the high intrarenal pressure-associated complications. We aimed to investigate whether there is a difference between prone and supine PCNL in terms of infective complications. This retrospective study includes 182 patients who underwent supine and prone PCNL due to kidney stones in our clinic between April 2020 and May 2022. Demographic (age, sex, body mass index, comorbidities), radiological (cumulative stone burden, stone density, number of stones, stone localization, stone laterality, presence of hydronephrosis), clinical (previous stone surgery, previous urinary tract) and perioperative (prone or supine position, surgery duration, hospitalization, success, non-infective and infective complications) data of all patients were evaluated. All patients were divided into two groups, the prone position group, and the supine position group. These two groups were compared in terms of pre and post-operative data above. Infective complications were observed in 16 (18%) patients in the prone position group and in 7 (7.5%) patients in the supine position group, and this difference was statistically significant (p = 0.034). Surgery duration (OR = 1.041;95% Cl = 1.021–1.061; p < 0.001), number of stones (OR = 4.09;95% Cl = 1.093–7.309; p = 0.036), previous urinary tract infection (OR = 6.272;95% CI = 1.936–9.317; p = 0.002) and prone position (OR = 4.511;95% CI = 1.265–7.087; p = 0.02) were found as independent risk factors for infective complications. Prone position was proved as an independent predictor of postoperative infectious events. Supine PCNL will be further adopted as the standard PCNL approach by a continuously growing proportion of endourologists.
Agriculture without paraquat is feasible without loss of productivity. Lessons learned from phasing out a highly hazardous herbicide
Authors: Stuart Alexander M. , Merfield Charles N. , Horgan Finbarr G. , Willis Sheila , Watts Meriel A. , Ramírez-Muñoz Fernando , U. Jorge Sánchez , Utyasheva Leah , Eddlestone Michael , Davis Mark , Neumeister Lars , Sanou Manoé R. R. , Williamson Stephanie
Published: August 2022

A small proportion of the thousands of pesticides on the market today are associated with a disproportionately high incidence of severe acute pesticide poisoning and suicide. Paraquat stands out as one of the most lethal pesticides in common use, frequently involved in fatal incidents due to suicides or accidental exposure. Even though paraquat has been banned in over 67 countries, it is still widely used in many others. Based on a literature review and consultation process, this paper identifies options for replacing paraquat and distils practical lessons from numerous successes around the world. Our aim is to support regulators, policy makers, agronomists and the supply chain sector with practical information related to phasing out paraquat. Production data consistently failed to show any negative impact of banning paraquat on agricultural productivity. A wide range of alternative approaches to weed management and crop defoliation are available, many of which do not rely on herbicides. Over 1.25 million farmers in low- and middle-income countries (LMICs) successfully produce a range of crops for private voluntary standards (PVS) in food and fibre supply chains which prohibit paraquat use. We conclude from the findings of this study that eliminating paraquat will save lives without reducing agricultural productivity. Less hazardous and more sustainable alternatives exist. To enhance successful adoption and uptake of these methods on a wide scale, farmers require training and support within an enabling policy environment.
The contribution of the donated human embryos suitable for production of embryonic stem cells to increase the quality of life: selection and preparation of embryos in Czech Republic
Authors: Ventruba Pavel , Ješeta Michal , Žáková Jana , Souralová Tereza , Koutná Irena , Hampl Aleš , Lousová Eva , Crha Igor , Ventruba Tomáš
Published: August 2022

Human embryonic stem cells (hESCs) are used in cell therapy mainly in targeted therapy for not yet curable diseases such as diabetes mellitus, spinal cord injury or Parkinson's disease. The aim of this study is the derivation of clinical-grade hESCs, usable in drug development, non-native medicine and cell therapy. Embryos were thawed, cultivated to the blastocyst stage if necessary, and subsequently assisted hatching was performed. From 1/2018 to 7/2020, 138 selected clients were asked for consent with the donation, of whom 52 did not respond, 19 terminated and 29 extended embryo storage. Only 38 clients (27.5%) agreed to donate their embryos for the derivation of hESCs. At the same time, personal communication with clients took place and another 17 embryo donors were obtained. A total of 160 embryos from 55 donors aged 26–42 years were collected. The embryos were frozen at blastocyst (33.1%) or morula (46.3%) stage. A total of 160 donated embryos were obtained. After preparation of 64 embryos, the embryoblast was isolated and subsequently cultured. Finally, 7 hESC lines were obtained, 4 research-grade lines and 3 clinical-grade lines, the first created in the Czech Republic.
Effects of crop rotation and soil tillage on suppressing the syndrome “basses richesses” vector Pentastiridius leporinus in sugar beet
Authors: Pfitzer René , Rostás Michael , Häußermann Patrick , Häuser Thilo , Rinklef André , Schrameyer Klaus , Voegele Ralf T. , Maier Johann , Varrelmann Mark
Published: August 2022

The planthopper Pentastiridius leporinus (Hemiptera: Cixiidae), is the most important vector of syndrome “basses richesses” (SBR) in sugar beet; it leads to severe economic losses. Planthoppers have probably adapted recently from reed grass (Phragmites australis) to sugar beet - winter wheat crop rotations. So far, no reliable vector control strategies are available. In this study, field assays were performed to test different soil tillage methods and crop rotations as potential management options. Barley, spring wheat, maize, bare soil and winter wheat (control) were grown using different soil tillage treatments (ploughing and cultivator) after sugar beet harvest. In five of seven field trial sites, reduced tillage did not differ from ploughing and, in two trial sites, it resulted in even higher numbers of emerging planthoppers. In nearly all field sites, consistent and significant reductions (up to 98.9%) of emerging adults were detected in the bare soil and maize treatments when compared to winter wheat. The survival and development of first instar nymphs were then studied on wheat, barley, and maize seedlings in the laboratory to confirm the field observations. The lowest survival was found in nymphs feeding on maize seedlings (4.2%), while 29.2% survived on barley, and 66.7% on wheat, over a period of 300 days. Almost 90% of nymphs in the maize treatment died after eight days. These results suggest that maize is a poor host for P. leporinus first instar nymphs. A combination of soil tillage and late sown specific spring crops are discussed as options for P. leporinus control.
Assessing Anxiety and Attitudes Towards Arithmetic and Algebra
Authors: Jasani Darshini
Published: August 2022

The study aimed at assessing the anxiety levels and attitudes of 68 students of Grades 11 and 12 studying the International Baccalaureate Diploma Program towards the math components of arithmetic and algebra by using a quantitative correlational study. Two survey instruments were used where the first section consisted of an achievement test for each branch of arithmetic and algebra. The second section consisted of an eighteen-item five-point Likert scale where the anxiety levels and attitudes of the students were assessed. The results showed that a negative correlation existed between anxiety levels and performance for both, arithmetic and algebra and a weak positive correlation existed between attitudes and performance. Additionally, significant differences existed in anxiety levels and attitudes between high and low performers for each component. Thus, although arithmetic and algebra were components that students had high familiarity with, the anxiety levels and attitudes towards them were different.
Trends and variability in the Southern Annular Mode over the Common Era
Authors: King Jonathan , Anchukaitis Kevin , Allen Kathryn , Vance Tessa , Hessl Amy
Published: August 2022

The Southern Annular Mode (SAM) is the leading mode of atmospheric variability in the extratropical Southern Hemisphere and has wide ranging effects on ecosystems and societies. Despite the SAM’s importance, paleoclimate reconstructions disagree on its variability and trends. Here, we use data assimilation to reconstruct the SAM over the last 2000 years using temperature and drought-sensitive climate proxies. Our method does not assume a stationary relationship between proxy records and the SAM over an instrumental calibration period, so our reconstruction is less sensitive to the teleconnection variability that has hindered previous reconstructions. Our approach also allows us to identify critical paleoclimate records and quantify reconstruction uncertainty through time. We find no evidence for a forced response in SAM variability prior to the 20th century. We also find the modern positive trend is outside the range of the prior 2000 years, but only on multidecadal time scales.
Teleportation of masked information
Authors: Abdelwahab A. G. , Ghwail S. A. , Metwally N. , Mahran M. H. , Obada A. -S. F.
Published: August 2022

In this contribution, we investigated the possibility of teleporting classical/quantum masked information, which may coded either in a single qubit or qutrit. For this purpose, different systems are used as quantum channels; two-qubit, three-qubit, two qutrit systems, and different protocols are applied. All the teleported masked information are retrieved as masked states at the receiver station. The number of operations that may be performed by the receiver are limited. It is shown that, one can teleport masked classical information with maximum fidelity, while for quantum information the maximization depends on the weight parameter of the tele-ported state. Teleporting the total masked state is better than teleporting its marginals, where the fidelity of total masked state is maximum. However, the fidelity of teleporting masking quantum information via three qubit systems may be maximized by controlling the weight of the initial masked state and the polarization of the mediator. In some cases, the receiver need to diagonalize the final teleported state to maximize its fidelity, and consequently reduces the required local operations.
On relation between statistical geometric mean and statistical summability (C,1) and it’s application to positive linear operators
Authors: Alotaibi Trad
Published: August 2022

In this paper, we introduce the relation between statistical geometric mean and statistical summability (C, 1) by using Caushy inequality. Then, we investigate a Korovkin type approximation by using G-statistical convergence for a sequence of positive linear operators.
Integrated single-cell and bulk RNA sequencing analysis revealing the role of FCGR2A on prognosis and immune infiltration of hepatocellular carcinoma
Authors: Tang Shaohai , Bai Yi , Chen Dapeng , Wang Yifan , Zhang Yamin
Published: August 2022

Objective To assess potential prognostic biomarkers of hepatocellular carcinoma (HCC) and preliminarily investigate their immune-related functions.Methods The CIBERSORT and ESTIMATE computational methods were applied to analyze the tumor microenvironment (TME) using the transcriptome and clinical data of HCC from The Cancer Genome Atlas (TCGA) database. The target gene was screened by intersecting the PPI network with Univariate Cox Regression Analysis. The distribution of the target gene expression in tumor-infiltrating immune cells (TICs) and immunological function were explored. Quality control, principal component analysis, TSNE clustering analysis, and cell annotation were also performed after downloading the single-cell RNA-sequencing data from the NCBI-GEO database. Lastly, we analyzed the distribution of the target gene at the single-cell level and established a comprehensive network of immune-related functions.Results Of the five hub genes (MMP9, FCGR2A, TLR2, CCR1 and PLAUR), FCGR2A was identified as the target gene following intersection analysis. It was up-regulated in tumor tissues and associated with poor prognosis of HCC patients. TSNE clustering study yielded 35 clusters, with hepatocyte, T cell, NK cell, macrophage, monocyte, B cell, smooth muscle cell, and endothelial cell as the result of annotation. Two of the results were related to immunological function. CIBERSORT analysis for the proportion of TICs revealed an increase in eosinophil number in tissues with low expression of FCGR2A. At the single-cell level, FCGR2A was mainly distributed in macrophages and monocytes.Conclusion This study showed that FCGR2A had an immunological role in the mono-macrophage system, was a promising biomarker for poor survival and could be a novel therapeutic target for HCC.
Using piRNA interference to quantify acute and inherited silencing in Caenorhabditis elegans with no requirement for genetic crosses: a case study.
Authors: Priyadarshini Monika , AlHarbi Sarah , Frøkjær-Jensen Christian
Published: August 2022

We recently developed a piRNA-based silencing assay called piRNA interference (piRNAi), where acute gene silencing is mediated by synthetic piRNAs expressed from extra-chromosomal array. Arrays are spontaneously lost every generation which can be used to quantify the persistence of silencing in the absence of a silencing trigger piRNAs. The assay allows inheritance assays by injecting piRNAs directly into mutant animals and targeting endogenous genes (e.g., him-5 and him-8) with obvious phenotypes (increased male frequency). In some cases this approach is advantageous because genetic crosses, especially for transgenes that are unpaired during meiosis, can have a large influence on epigenetic silencing. Here we demonstrate the use of the piRNAi assay by silencing in the ribonucleotidyltransferase rde-3 (ne3370) mutant and quantifying acute and inherited silencing. We find that in the absence of rde-3, acute silencing is reduced but still detectable, whereas we see no evidence of inherited silencing.
Prevalence of Sexual Dysfunction in Physically Active Female University Students: A Case-Control Study
Authors: Rosseto Patricia Pelegrina , de Araujo Maita Poli , Silva Ivaldo da
Published: August 2022

Objective:To investigate the prevalence of sexual dysfunctions in physically active versus sedentary female university students.Methods:Cross-sectional case-control survey study, involving 202 female university students aged 18–40 years (180 who performed regular physical activity and 22 sedentary students, in the same age group). Sexual function was evaluated by the Female Sexual Function Index.Results:Sexual dysfunction was more prevalent in sedentary (45.5%) than physically active participants (38.9%; p = 0.646). In relation to the domains valued by Female Sexual Function Index, only “excitation” presented a statistically significant difference (p = 0.031).Conclusion:Prevalence of sexual dysfunction was similar in active and sedentary female university students.
Interocular symmetry and intermachine reproducibility measured by two different models of Cirrus optical coherence tomography
Authors: Firdaus Salma , Pereira Livia Figueiredo , Yang Ge , Huang-Link Yumin
Published: August 2022

Background: Optical coherence tomography (OCT) is a non-invasive, sensitive and reliable method to measure retinal axonal and neuronal changes quantitatively at a few micrometers. Spectral-domain high definition OCT (HD-OCT) has been used globally and upgraded over the years several times Objective: This prospective study aims to compare interocular symmetry of the optic disc and macular data measured by Cirrus HD-OCT 4000 and HD-OCT 5000; to determine the intermachine reproducibility of the data from healthy subjects examined at the same visit by both HD-OCT models. Materials and Methods: Forty-three volunteers were recruited for this study. Participants were examined with both HD-OCT 4000 and HD-OCT 5000 at the same visit. Data of optic nerve head (ONH) were acquired using ONH Cube 200 x 200 scans. Macular data were acquired using macular volume cube 512 x 128 scans. Results: The average age of the participants was 33 ± 8.6 years. Interocular OCT parameters of ONH and macula were highly correlated between the right and left eyes regardless of HD-OCT 4000 or 5000. The average retinal nerve fiber layer (RNFL) thickness was thicker (96.67±11.19µm vs. 95.3±10.89µm, p<0.01), but average central subfield thickness (261.51±17.45µm vs. 262.51±17.39 µm, p<0.01) and average cube thickness (283.91± 13.59 µm vs. 286.55±13.09 µm, p<0.05) were thinner as measured by HD-OCT 4000 than by HD-OCT 5000. Intermachine reproducibility and reliability of the macular parameters and RNFL are good with high intraclass correlation coefficient (ICC) and low coefficient of variation (CV). Ganglion cell-inner plexiform layer (GCIPL) in the macula measured by two OCT models was close to each other with an average thickness of 85 µm and had high intermachine reproducibility with high ICC (0.993) and low CV (1.2%). Conclusion: The interocular symmetry from both HD-OCT models was high. Intermachine reproducibility for RNFL and all macular parameters was also high. GCIPL has small intermachine differences and high reproducibility with perfect reliability. The results imply that GCIPL values measured by two HD-OCT models maybe used interchangeably.
Stability and conditioning of immersed finite element methods: analysis and remedies
Authors: de Prenter Frits , Verhoosel Clemens. V. , Brummelen E. Harald van , Larson Mats G. , Badia Santiago
Published: August 2022

This review paper discusses the developments in immersed or unfitted finite element methods over the past decade. The main focus is the analysis and the treatment of the adverse effects of small cut elements. We distinguish between adverse effects regarding the stability and adverse effects regarding the conditioning of the system, and we present an overview of the developed remedies. In particular, we provide a detailed explanation of Schwarz preconditioning, element aggregation, and the ghost penalty formulation. Furthermore, we outline the methodologies developed for quadrature and weak enforcement of Dirichlet conditions, and we discuss open questions and future research directions.
Amplification of Annual and Diurnal Cycles of Alpine Lightning
Authors: Simon Thorsten , Mayr Georg J. , Morgenstern Deborah , Umlauf Nikolaus , Zeileis Achim
Published: August 2022

The response of lightning to a changing climate is not fully understood. Historic trends of proxies known for fostering convective environments suggest an increase of lightning over large parts of Europe. Since lightning results from the interaction of processes on many scales, as many of these processes as possible must be considered for a comprehensive answer. Recent achievements of decade-long seamless lightning measurements and hourly reanalyses of atmospheric conditions including cloud micro-physics combined with flexible regression techniques have made a reliable reconstruction of lightning down to its seasonally varying diurnal cycle feasible. To include a large variety of land-cover, topographical and atmospheric circulation conditions, the European Eastern Alps and their surroundings are our reconstruction region over a period of four decades. The most intense changes occurred over the high Alps where lightning activity doubled in the past decade compared to the 1980s. There, the lightning season reaches a higher maximum and starts one month earlier, likely due to the earlier snow melt. Diurnally, the peak is up to 50% stronger with more lightning strikes in the afternoon and evening hours. Signals along the southern and northern alpine rim are similar but weaker whereas the flatlands north of the Alps have no significant trend.
Propriedade intelectual para a inovação: um guia para estudantes do ensino médio
Authors: Marques de Carvalho Joélia , Vasconcelos Freire Verônica Maria
Published: August 2022

Apresenta informações básica de propriedade intelectual e inovação tecnológica voltada para o público do ensino médio.
YUNUS EMRE ARAŞTIRMALARININ BUGÜNKÜ DURUMU VE TEK NÜSHAYA DAYALI DİVAN NEŞİRLERİNİN GEREKLİLİĞİ
Authors: UYSAL İdris Nebi
Published: August 2022

Yunus Emre araştırmaları Fuat Köprülü’nün Türk Edebiyatında İlk Mutasavvıflar (1919) adlı eseriyle başlar. O tarihten sonra Yunus ve eserleri hakkında çok sayıda çalışma yapılmıştır. Fakat eserlerine yönelik dil incelemeleri yetersizdir. Fatih, Karaman ve Bursa dışındaki nüshaların müstakil neşirleri de henüz yapılmamıştır. Türkoloji’de birden fazla nüshaya sahip eserler genellikle edisyon kritik yöntemiyle çalışılmıştır. Bu usul, edebiyat araştırmacıları için elverişli olsa da dilcilik açısından kullanışlı değildir. Dil araştırmalarında bir ekin bile önemli olduğu düşünüldüğünde böyle metinlerin her nüshasını ayrı ayrı çalışmanın değeri daha iyi anlaşılacaktır. Konuyu daha anlaşılır kılmak için herkesçe bilinen bir şiirle onun taç beyti örnek olarak seçilmiştir. Bu; Fatih, Avusturya, Türk Tarih Kurumu, Vatikan, Vahitpaşa 2, Nuruosmaniye nüshalarında bulunan, taç beyti “Gelin tanış olalım işi kolay kılalım / Sevelim sevilelim dünya kimseye kalmaz” olan manzumedir. Beytin ilk dizesi özellikle söz varlığı bakımından birbirinden farklıdır. Nüshalarda fiil tanış ol- değil “istişare etmek” anlamındaki danışık / tanışık / tanşuk et-’tir. Kıl- fiili ise hiç geçmemektedir. Yerine tut- / güt- fiilleri kullanılmıştır. Kolay / oñat ve iş / iz kelime tercihleri de diğer farklardır. Tek nüshaya dayalı filolojik neşirlerin yapılması nüshalarla ilgili tarihlendirme, ana nüshaları tespit etme, şairin kişisel kelime servetini belirleme gibi konularda katkı sağlayacaktır. Eserin istinsah edildiği dönem ile ait olduğu sahanın dil ve ağız özelliklerini de ortaya çıkaracaktı
ESKİ UYGURCA MAYTRISİMİT’TE YER ALAN ALINTILI MONOLOG TÜRLERİ ÜZERİNE BİR DEĞERLENDİRME
Authors: ŞEHİTOĞLU Muammer
Published: August 2022

Tarihî olarak yazı dillerindeki edebî ürünler, sözlü dildeki geleneksel anlatım tekniklerini en iyi şekilde kullanmalarının yanı sıra çağdaş anlatı türlerine ait anlatım tekniklerinin de etkili kullanıldığı ürünler olmuşlardır. Türkçenin önemli tarihî dönemlerinden Eski Uygur Türkçesi döneminin dikkat çekici eserlerinden biri olan Maytrısimit adlı eser de anlatım tekniği açsından üst seviye bir edebî eser niteliği göstermektedir. Budist öğretinin kutsal kitabı sayılan eser, çağdaşı olan diğer eserlerden farklı olarak “ülüş” şeklinde bölümler hâlinde yazılarak, her bir bölümün sahne şeklinde kabul edildiği bir dram eseri hüviyetindedir. Eserin bölümlerinde, doğrudan konuşma örgüsü unsurlarının yer almadığı metin bölümlerinde çağdaş anlatı türlerinde kullanılan teknikler dikkat çekmektedir. Çalışmada, eserde yer alan alıntılı monologların çağdaş anlatım tekniği bakımından ele alınması; monolog türlerinin, kullanılan monologların işlevlerinin tespit edilmesi ve eser metninin bu yönünün önemine dikkat çekilmesi amaçlanmıştır. Eserde elde edilen bulgularda, alıntılı monologların tarihî süreçteki örnekleri ile karşılaştırıldığında çağdaş anlatım tekniği olarak benzerlikler gösterdiği tespit edilmiş ve aynı dönemde kendisinden sonra kaleme alınmış eserler içinde model olduğu değerlendirilmiştir.
GÖKTÜRK DÖNEMİNE AİT NADİR SUNAK ÖRNEKLERİ (SUNAK TAŞI/ALTAR)
Authors: KOÇAK Kürşat
Published: August 2022

Bu araştırmada 2001-2004 yılları arasında yapılan Bilge Kağan anıt alanı arkeolojik çalışmalarında ortaya çıkarılan Sunak başta olmak üzere Kül Tegin ve Nomgon I sunakları hakkında bilgi verilecektir. Atalar kültüne bağlı olarak kurban sunma ritüelinin yapıldığı sunu alanındaki büyük granit sunak taşı incelenecektir. Bilge Kağan anıt alanında toprak örtünün kaldırılması esnasında tam olarak ortaya çıkma anı 2001 yılında L. Gürkan GÖKÇEK tarafından ilk defa fotoğraflanmıştır. Fotoğraflar Ahmet TAŞAĞIL’ın belirttiği üzere tarihi belge niteliğindedir. Bu çalışmanın temel amaçlarından biri 21 yıl sonra ortaya çıkan bu fotoğrafları yayınlamaktır.
YÖNETİME ETKİLERİ BAĞLAMINDA ÜÇ İKTİDAR VE ÜÇ KADIN: TERKEN HATUN, HAYZÜRÂN, ELEANOR OF AQUİTAİNE
Authors: KAPAR Mehmet Ali
Published: August 2022

Kadın ilk çağlardan itibaren her alanda varlık savaşı vermiştir. Genel olarak varoluşlarından itibaren içgüdüsel bir şekilde her şeyi paylaşan kadın ve erkeğin arasında, medeniyetlerin gelişimiyle, özellikle yönetim alanında büyük bir uçurum oluşmuştur. Zamanla erkek egemen toplumlar meydana çıkmış ve kadınlar yönetimde arka planda kalmışlar, çoğu zaman erkek egemenliği kadın üzerinde genel bir tahakküm kurmuştur. Fakat mücadelesinden vazgeçmeyen kadın, bazı dönemlerde bu tahakkümü kırmayı başarabilmiş ve toplumun her kesiminde kendine yer edinmiştir. Toplumların oluşması ile yönetici erkler ortaya çıkmış ve yöneten ile yönetilen sınıflar doğmuştur. Nadiren de olsa yönetimi kadınların elinde tuttuğu bazı toplumlar olmakla birlikte genel olarak yönetim erkeklerin elinde olmuştur. Bu durumda ise kadın yönetime doğrudan müdahale edemese bile dolaylı yollardan müdahalelerde bulunarak etkisini sürdürmüştür. Kadının yönetime olan bu etkisi zaman, mekân ve toplumlara göre değişmiştir. Kadının doğrudan ülke yönetiminde bulunamadığı durumlarda etkilerini kocaları üzerinden gerçekleştirdiği de görülmüştür. Özellikle hükümdar eşleri yönetimdeki etkinliklerinin devamlı olması için sadece kendi eşleri üzerinden harekete geçmemişler, aynı zamanda ileride de kendi çocuklarının -hatta kendi çocukları arasından da kendilerinin daha rahat etkileyebilecekleri çocuklarının- hükümdar olması için mücadele etmişlerdir. Bu etkide en önemli unsur ait oldukları toplumların yönetimle ilgili örf, adet ve anlayışlarıdır. Zira inançlar, gelenek ve görenekler, toplumsal değerler kadınların etki alanlarını da belirlemiştir. Bu çalışmamızda üç farklı coğrafya -Batı Asya, Orta Aysa, Avrupa- ve üç farklı millete -Arap Türk, Frank- ait hükümdar eşlerinin yönetime olan etkileri incelenecek ve kıyaslama metodu uygulanarak yönetime etkilerinin benzer ve farklı yönleri ortaya konulmaya çalışılacaktır. Karakterler incelenirken dönem kaynakları merkezli olarak ele alınacaktır.
16. YÜZYILDA OSMANLI DEVLETİ’NDE ZİRAİ ÜRETİMİ ETKİLEYEN FAKTÖRLER ÜZERİNE BİR DEĞERLENDİRME
Authors: DEMİR Mustafa
Published: August 2022

16. yüzyıl Osmanlı Devleti’nde çok önemli değişim ve büyük olayların yaşandığı bir dönemdir. Askeri hareketler, nüfus artışı, küçük buzul çağı vb. gelişmeler üzerine bazı çalışmalar yapılmış, etkileri değerlendirilmiştir. Ancak tüm bu faktörlerin zirai üretime doğrudan ya da dolaylı etkisi konusunda ya çok az şey söylenerek boşluklar bırakılmış ya da küçük buzul çağının rolünde olduğu gibi hiçbir şey söylenmemiştir. Bu çalışmada Osmanlı tarımsal üretiminin bu gelişmelerden etkileniş biçimi incelenmektedir. Halkın temel besin kaynağı olan buğday ve binek ile iş hayvanları için birincil derecede önemli besin kaynağı olan arpa üretimindeki değişim temel alınmıştır. Buğday ve arpanın 16. yüzyılın ilk yarısı ile ikinci yarısındaki üretimlerinin kıyaslanması ve sonucun değerlendirilmesi bu etkilerin rolünü açığa çıkarmaktadır. Sonuçta üretim miktarı özelinde buğday ve arpa üretimi birbirinden bağımsızdır ve birçok durumda, ekim alanına bağlı olarak, buğday alan kaybederken arpa üretimi artmaktadır.
Molecular Interactions of Zyesami with the SARS-CoV-2 nsp10/nsp16
Protein Complex
Authors: Alnomasy Sultan F. , Alotaibi Bader S. , Aldosari Ziyad M. , Mujamammi Ahmed H. , Alzamami Ahmad , Anand Pragya , Akhter Yusuf , Khan Farhan R. , Hasan Mohammad R.
Published: August 2022

Background:

SARS-CoV-2 emerged in late 2019 and caused COVID-19. Patients treated
with Zyesami were found to have a 3-fold decrease in respiratory failure and improved clinical
outcomes. It was reported that Zyesami inhibits RNA replication of SARS-CoV-2, including several
non-structural proteins essential in viral RNA replication. SARS-CoV-2 is a distinctive virus
that requires nsp10 and nsp16 for its methyltransferases activity which is crucial for RNA stability
and protein synthesis.

Objective:

We aimed the in silico determination of inhibitory consequences of Zyesami on the
SARS-CoV-2 nsp10/nsp16 complex. Targeting SARS-CoV-2 nsp10/ nsp16 protein complex may
be used to develop a drug against COVID-19.

Methods:

I-TASSER was used for secondary structure prediction of Zyesami. CABS-dock was
used to model Zyesami with SARS-CoV-2 nsp16 interaction. The docked complex was visualized
using PyMol. The quality of the docking model was checked by using ProQdock.

Results:

The 3D structure of SARS-CoV 2, nsp10/nsp16 showed that essential interactions exist
between nsp10 and nsp16. Significant contact areas of Zyesami exist across amino acid residues of
nsp10; Asn40-Thr47, Val57-Pro59, Gly69-Ser72, Cys77-Pro84, Lys93-Tyr96. In addition, polar contacts
between nsp16 and Zyesami are Asn299-Ser440, Val297-Asn443, Gly149-Tyr437, Gln159-Lys430, Asn178-
Arg429, Ser146-Arg429, Ser146-Arg429, Lys147-Arg429, Asr221-Thr422, Lys183-Asp423, Lys183-Asp423, and
Gln219-Asp423 the residues are shown of nsp16 and Zyesami respectively.

Conclusion:

The structural bioinformatics analyses have indicated the potential binding specificity
of Zyesami and nsp16. Data predict how the initial binding of Zyesami with nsp10 and nsp16 may
occur. Moreover, this binding could significantly inhibit the 2 -O-MTase activity of the SARSCoV
nsp10/16 complex.
Effects of Health Intentions and Health-promoting Behavior on Selfesteem
among School-aged Children in South Korea
Authors: Cha Nam Hyun , Kim Jin , Jeon Ga Eul
Published: August 2022

Background:

The purpose of this study was to identify the predictors of self-esteem and
the relationships between health-promoting behavior, health intentions, and self-esteem among
school-aged children and provide basic data for the development of programs that can influence
self-esteem among school-aged children in South Korea.

Introduction:

This study aimed to identify the predictors of self-esteem and the relationships between health intentions and health-promoting behavior and self-esteem among school-aged children.

Methods:

The study design was a cross-sectional study. The data were collected using a selfreported questionnaire on health intentions, health-promoting behavior, and self-esteem. The data
were collected from elementary school students from February 3 to 13, 2020. Data analysis was performed using the SPSS program

Results:

Positive correlations were found between self-esteem and both health-promoting behavior
(r=.503, p<0.001) and health intentions (r=.511, p<0.001). Also, the relationship between health intentions and health-promoting behavior (r = 0.629, p < 0.001) exhibited positive correlation. Self-esteem
was identified as a significant predictor of health intentions (β = 0.28, p < 0.001), health-promoting
behavior (β = 0.21, p < 0.001), school records (β = -0.20 p < 0.001), perceived health status (β =
0.18, p < 0.001), and academic grade (β = -0.10, p < 0.05), with an explanatory power of 39.0%.

Conclusion:

The results indicated that self-esteem positively affects health intentions and healthpromoting behavior