bluuebunny/crossref_metadata_2025 huggingface dataset:
A new anterior total hip arthroplasty reduction technique for patients who require leg lengthening
Authors: Oinuma Kazuhiro , Shiratsuchi Hideaki , Nakakita Yoshiatsu , Miura Yoko , Ninomiya Taishi
Published: June 2020

Background:

When performing anterior total hip arthroplasty (THA) for patients who require leg lengthening, surgeons often encounter difficulties during reduction due to soft tissue tightness. The purpose of this study was to introduce a new THA reduction technique for these patients.

Methods:

Between October 2018 and September 2019, 545 THAs were performed. In 15 hips (2.8%), reduction was not achieved with a traditional technique. The preoperative diagnosis was Crowe grade II in 4 hips, Crowe grade III in 4 hips, Crowe grade IV in 1 hip, and sequelae of Legg-Calvé-Perthes disease in 6 hips. All procedures were performed using a direct anterior approach. The new reduction technique was to use a lever hooked on the acetabular teardrop as a counter force against the preserved muscles. The lever was connected to the impactor with a wire and the counterforce was transmitted to the impactor.

Results:

Reduction was achieved in all cases without shortening osteotomy or muscle release. The mean lengthening of the operated limb was 30 mm (range 13–59 mm). Neither sciatic nor femoral nerve palsy were observed.

Conclusion:

We developed a new anterior THA reduction technique for patients who require leg lengthening. When the centre of the femoral head was reduced to the superior edge of the cup with the traditional technique, reduction was safely achieved with this technique.
Use of blood temperature monitor with Twister device for the surveillance of vascular access in maintenance hemodialysis: Comparison with Doppler ultrasonography
Authors: Lee Jun Young , Park Eung Joo , Chang Jae Hyun , Han Byoung-Geun , Kim Gheun-Ho
Published: June 2020

Background:

Regular monitoring of vascular access in patients on maintenance hemodialysis is important to detect early vascular access complications. We compared vascular access blood flow determined by blood temperature monitor and Doppler ultrasonography to evaluate the usefulness of blood temperature monitor.

Methods:

In total, 70 patients on maintenance hemodialysis were enrolled from three dialysis centers. Vascular access blood flow was measured thrice at 6-month intervals using Doppler ultrasonography to determine arterial inflow (Q-DUa), venous outflow (Q-DUv), and flow between punctures (Q-DUb) using BTM® (Q-BTM). Twister® was placed between the hemodialysis needle and blood lines, allowing simple reversal of flow without stopping the hemodialysis pump.

Results:

In total, 203 measurements were recorded, with median values (interquartile range) for Q-BTM, Q-DUa, Q-DUv, and Q-DUb of 1139.0 (868.0–1588.0) mL/min, 960.3 (658.7–1380.4) mL/min, 946.0 (552.0–1515.0) mL/min, and 1067.7 (544.8–1635.0) mL/min, respectively. For all measurements, the mean intraclass correlation coefficients were 0.52 (95% confidence interval, 0.36–0.64) for Q-DUa; 0.37 (95% confidence interval, 0.15–0.53) for Q-DUv; and 0.45 (95% confidence interval, 0.26–0.59) for Q-DUb. Analysis of a receiver operating characteristics curve yielded a cut-off of 627 mL/min for Q-BTM to predict stenosis.

Conclusion:

In patients on maintenance hemodialysis, blood flow measured by blood temperature monitor moderately correlated with Doppler blood flow. It was more related to arterial inflow than venous outflow or flow between punctures. The blood temperature monitor method was not inferior to Doppler ultrasonography. Therefore, blood temperature monitor could be recommended for routine vascular access monitoring because it can be done quickly without interrupting dialysis.
Solutions to stuck tunneled cuffed catheters in patients undergoing maintenance hemodialysis
Authors: Yongchun He , Hua Jiang , Xiaohan Huang , Jianghua Chen , Ping Zhang
Published: June 2020

Objective:

To study and discuss treatments for stuck tunneled cuffed catheter in patients undergoing maintenance hemodialysis.

Method:

Retrospectively analyzing clinical data of 13 patients with stuck tunneled cuffed catheter in the Kidney Disease Center of the First Affiliated Hospital, College of Medicine, Zhejiang University in the period between September 2012 and October 2018. All patients failed to remove hemodialysis catheters by regular technique. The stuck catheters were treated by thoracotomy, endoluminal percutaneous transluminal angioplasty with blunt dissection or embedded and left in situ.

Results:

In 13 patients, one was successfully treated by thoracotomy, one failed to remove the catheter by regular technique and blunt dissection, and the stump of the catheter was clamped and buried in the subcutaneous fascia of the neck, and the other 11 were treated by endoluminal percutaneous transluminal angioplasty with blunt dissection. The average time of catheter removal procedure is 25 min, the overall success rate is 92.3%, and the success rate of percutaneous transluminal angioplasty is 100%.

Conclusion:

Thoracotomy is an efficient way to treat stuck catheter but is limited by its high risk and complications. Leaving part of catheter in situ may increase the risk of central vein stenosis. Comparing to the former two, endoluminal percutaneous transluminal angioplasty is a safe, efficient, and practical way for stuck catheters and should be recommended as the first choice.
Severe hemodialysis access-induced distal ischemia may be associated with poor survival
Authors: Gerrickens Michael W M , Yadav Reshabh , Wouda Rosanne , Beerenhout Charles H , Scheltinga Marc R M
Published: June 2020

Background:

Some hemodialysis patients develop hemodialysis access-induced distal ischemia due to insufficient loco-regional perfusion pressure and consequent poor arterial flow. We hypothesized that patients with severe hemodialysis access-induced distal ischemia had worse survival compared with patients with mild or no hemodialysis access-induced distal ischemia.

Methods:

This single-center retrospective observational cohort study included three groups of prevalent hemodialysis patients with an upper extremity vascular access between 2006 and 2018. Symptomatic patients had signs and symptoms of hemodialysis access-induced distal ischemia and low digital brachial indices (<60%) and were divided into a mild (Grade I–IIa) and a severe hemodialysis access-induced distal ischemia (IIb–IV) group. The control group consisted of hemodialysis patients without signs of hemodialysis access-induced distal ischemia with digital brachial indices ≥60%. Factors potentially related to 4-year survival were analyzed.

Results:

Mild hemodialysis access-induced distal ischemia-patients displayed higher digital brachial indices ( n = 23, 41%, ±3) compared with severe hemodialysis access-induced distal ischemia-patients ( n = 28, 24%, ±4), whereas controls had the highest values ( n = 48, 80%, ±2; p < .001). A total of 44 patients (44%) died during follow-up. Digital brachial index (hazards ratio 0.989 [0.979–1.000] p = .046) was related to overall mortality following correction for presence of arterial occlusive disease (hazards ratio 2.28 [1.22–4.29], diabetes (hazards ratio 2.00 [1.07–3.72], and increasing age (hazards ratio 1.03 [1.01–1.06] as was digital pressure (hazards ratio 0.990 [0.983–0.998], p = .011). Overall survival was similar in mild hemodialysis access-induced distal ischemia and controls (2-year, 79% ±5; 4-year, 57% ±6, p = .818). In contrast, 4-year survival was >20% lower in patients with severe hemodialysis access-induced distal ischemia (2-year 62%± 10; 4-year 34% ± 10; p = .026).

Conclusion:

Presence of severe hemodialysis access-induced distal ischemia may be associated with poorer survival in hemodialysis patients. Lower digital brachial index values are associated with higher overall mortality, even following correction for other known risk factors.
Molecular tracking of pathogens in central venous catheter
Authors: Lara Maristela Oliveira , Lucas Thabata Coaglio , kalapothakis Evanguedes , Thomasini Ronaldo Luis , Machado Carla Jorge
Published: June 2020

Background:

Central venous catheter–related bloodstream infection is an important adverse event in health care. Molecular methods are not yet substitutive of microbiological in the detection of the pathogens responsible for the infection, but they can help in the epidemiological characterization.

Aim:

To detect bacteria by polymerase chain reaction, from material extracted from the tip of central catheters of patients suspected of infection at the intensive care unit.

Methods:

Catheters (n = 34) of patients suspected of central venous catheter–related infection were analyzed by polymerase chain reaction. The findings were compared with culture of catheter tip and blood cultures performed by the hospital.

Findings:

The prevalence of bacteria was Staphylococcus aureus (50%), Enterococcus faecalis (41.2%), Klebsiella pneumoniae (32.4), Pseudomonas aeruginosa (20.6%), Acinetobacter baumannii (38.2%), Escherichia coli (2.9%), and Enterobacter cloacae (0%). No blood culture showed bacterial growth, the culture of catheter tip revealed bacteria in 21 (61.8%) and the polymerase chain reaction had positivity in 31 (91.2%) of the catheters. The mean central venous catheter time was 11 days, and the jugular vein was the site of insertion.

Conclusion:

The molecular method identified more bacteria than microbiological methods and revealed colonization of the catheters. The most commonly found bacteria are in the environment and in the microbiota of the skin, which suggests contamination by the hands of health professionals and points out the need for more efforts in preventive strategies.
A Novel Cecropin D-Derived Short Cationic Antimicrobial Peptide Exhibits Antibacterial Activity Against Wild-Type and Multidrug-Resistant Strains of Klebsiella pneumoniae and Pseudomonas aeruginosa
Authors: Ocampo-Ibáñez Iván Darío , Liscano Yamil , Rivera-Sánchez Sandra Patricia , Oñate-Garzón José , Lugo-Guevara Ashley Dayan , Flórez-Elvira Liliana Janeth , Lesmes Maria Cristina
Published: June 2020

Infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa and Klebsiella pneumoniae are a serious worldwide public health concern due to the ineffectiveness of empirical antibiotic therapy. Therefore, research and the development of new antibiotic alternatives are urgently needed to control these bacteria. The use of cationic antimicrobial peptides (CAMPs) is a promising candidate alternative therapeutic strategy to antibiotics because they exhibit antibacterial activity against both antibiotic susceptible and MDR strains. In this study, we aimed to investigate the in vitro antibacterial effect of a short synthetic CAMP derived from the ΔM2 analog of Cec D-like (CAMP-CecD) against clinical isolates of K pneumoniae (n = 30) and P aeruginosa (n = 30), as well as its hemolytic activity. Minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) of CAMP-CecD against wild-type and MDR strains were determined by the broth microdilution test. In addition, an in silico molecular dynamic simulation was performed to predict the interaction between CAMP-CecD and membrane models of K pneumoniae and P aeruginosa. The results revealed a bactericidal effect of CAMP-CecD against both wild-type and resistant strains, but MDR P aeruginosa showed higher susceptibility to this peptide with MIC values between 32 and >256 μg/mL. CAMP-CecD showed higher stability in the P aeruginosa membrane model compared with the K pneumoniae model due to the greater number of noncovalent interactions with phospholipid 1-Palmitoyl-2-oleyl-sn-glycero-3-(phospho-rac-(1-glycerol)) (POPG). This may be related to the boosted effectiveness of the peptide against P aeruginosa clinical isolates. Given the antibacterial activity of CAMP-CecD against wild-type and MDR clinical isolates of P aeruginosa and K pneumoniae and its nonhemolytic effects on human erythrocytes, CAMP-CecD may be a promising alternative to conventional antibiotics.
Prolonged Pyrexia: Kikuchi-Fujimoto Disease in a Patient With Hb H-Constant Spring Thalassemia
Authors: Kasinathan Ganesh
Published: June 2020

Introduction:

Haemoglobin H (Hb H) disease is an alpha thalassemia characterised by either 3 alpha-globin gene deletions (deletional type) or 2 alpha-globin gene deletions with 1-point mutation (nondeletional type). Haemoglobin H-Constant Spring thalassemia is the most common Hb H disease in Asia. Kikuchi-Fujimoto disease (KFD) is an important cause of prolonged fever in thalassemia and is often self-limiting.

Case Presentation:

A 30-year-old women of Malay ethnicity presented to the thalassemia unit with a month history of prolonged fever, headache, and painful enlarged neck lymph nodes. She is known to have Hb H-Constant Spring thalassemia, in which she is on 3-monthly blood transfusion. Physical examination revealed persistent pyrexia of 38°C. She had multiple tender bilateral cervical lymphadenopathies with the largest measuring 4 × 4 cm. The complete blood count revealed hypochromic microcytic anaemia with leucopenia and a normal platelet count. She had hyperferritinemia of 3500 ng/mL. The DNA analysis of alpha-globin gene showed heterozygosity for alpha zero thalassemia South East Asian deletion with termination codon mutation (TAA-CAA) which was consistent with Hb H-Constant Spring thalassemia. Numerous investigations for her prolonged fever including cultures did not yield any positive results. Whole-body computed tomography (CT) imaging showed diffuse lymphadenopathies and hepatosplenomegaly. Finally, a left cervical lymph node biopsy was performed which was consistent with KFD. She was treated with oral prednisolone which was gradually tapered based on response. Currently, she is asymptomatic and is in complete remission.

Conclusion:

Kikuchi-Fujimoto disease should be considered as a cause for prolonged pyrexia in a patient with thalassemia. An early diagnosis of KFD would avoid an unnecessary battery of investigations. This case highlights the importance of clinicopathological correlation in managing patients with thalassemia as these patients often have other associated morbidities.
Childhood trauma and type D personality: The endocrine and cardiovascular effects on stress reactivity
Authors: Bahari Ali , Hasani Jafar , Mashhadi Akbar Boojar Masoud
Published: June 2020

Both exaggerated and blunted cardiovascular stress reactions are associated with health problems. Moreover, early life experiences and personality traits affect stress responses. Regarding the childhood traumas and type D personality, this study aimed to compare the endocrine and cardiovascular reactions against acute laboratory stress. Results showed that the simultaneous existence of childhood traumatic experiences and type D personality leads to exaggerated stress reactivity, while each factor results in a blunted cardiovascular response. Although the cardiovascular responses are dampened in type D personality people, their endocrine reactions are exaggerated. The underlying mechanisms of blunted cardiovascular reactivity differ between childhood trauma and type D personality groups.
Emotional distress among parent caregivers of adolescents with sickle cell disease: Association with patients and caregivers variables
Authors: Bioku Ayodeji A , Ohaeri Jude U , Oluwaniyi Stephen O , Olagunju Tinuke O , Chaimowitz Gary A , Olagunju Andrew T
Published: June 2020

Evidence suggests that impairment in caregiver wellbeing can alter the quality of care in children with sickle cell disease. We examined 121 parent caregivers of adolescents with sickle cell disease for emotional distress and disruptions to caregiver lifestyle and interests. Participants were predominantly mothers 92(76%) with mean age, 43.59 ( SD = 6.39) years. Four in every ten caregivers had emotional distress, and this was predicted by frequent hospital attendance and disruptions in caregiver lifestyle, relationships, and interests. Psychosocial support to promote resilience and adaptive coping-styles to deal with the stress from unforeseen crises, frequent hospital visits, and lifestyle disruptions are indicated to improve caregiver wellbeing.
Use of partial information to learn to read Chinese characters in non-native Chinese learners
Authors: Liu Yang , Zhang Jie , Li Hong
Published: June 2020

The ability to decode new words of varying degrees of orthographic-phonological mapping is an important word recognition skill across languages. Chinese characters represent three types of phonetic regularity: regular, semi-regular, and irregular depending on the degree of reliability of the pronunciation information provided by the phonetic component. This study investigated whether adult non-native Chinese learners can use partial phonological information encoded in semi-regular characters to learn the pronunciations of new characters. A total of 55 college students, enrolled in an intensive Chinese program with varying proficiency levels, were taught the pronunciations of 18 novel compound characters of three phonetic regularity types over three trials. Non-native Chinese learners of advanced and intermediate levels learned the pronunciations of regular characters (initial-same and final-same), which contain full information about pronunciation, and semi-regular characters (initial-different, final-same), which contain partial information about pronunciation, significantly better than irregular characters (initial-different and final-different), which contain misleading pronunciation information. The performance difference between semi-regular and irregular characters decreased over trials. Novice students demonstrated limited ability in using partial information to learn to pronounce characters compared to intermediate and advanced students. These results provide implications for effective character instruction for adult learners of Chinese with varying Chinese proficiency levels.
Hyper-articulation effects in Korean glides by heritage language learners
Authors: Chang Seung-Eun , Weiss-Cowie Samuel
Published: June 2020

Aims and objectives:

Hyper-articulation effects in glide sounds and heritage production are unexplored areas. Thus, this study examines how the Korean glide /we/ is phonetically implemented in hyper-articulated speech by English-speaking heritage learners of Korean. Language-specific fundamental frequency (F0) patterns and methodological issues involving inconsistent data in heritage research are also addressed.

Methodology:

Korean-American students enrolled in an intermediate-low Korean language course for Korean heritage students at a university in the US read four isolated sentences, once in casual speech and once in hyper-articulated (or clear) speech. They repeated this sequence five times.

Data and analysis:

The syllable duration of the glide more than doubled and the upward transitional feature of /w/ was significantly expanded with a steeper slope in clear speech compared to casual speech. The expansion of vowel space of /e/ in clear speech was also attested for second formant (F2). Although pitch did not vary between the two speaking styles at syllable onset or vowel midpoint, it exhibited a significant increase at syllable offset in clear speech. The strong intra- and inter-speaker variations frequently observed in heritage language research were not found in this study.

Conclusions:

The results generally echo the hyper-articulated speech changes observed in native Korean speakers. The pitch pattern outcomes suggest that heritage learners’ enhancement corresponds more to that of their heritage language than their dominant language. Although the data generally supports the idea that heritage learners’ enhancement strategies emulate those of native speakers in terms of exaggerated acoustic features, the same is not true regarding absolute acoustic values; their acoustic values are more exaggerated than native speakers’ in clear speech.

Originality and implications:

The findings present new hyper-articulation effects regarding glide sounds and an additional enhancement strategy of end-of-syllable pitch raising in hyper-articulated speech. This study also suggests that controlling for confounding population variables mitigates the methodological challenges of heritage language research.
The Olympic paradox: The Olympics and intergroup biases
Authors: Kim Youngju , Na Jinkyung
Published: June 2020

The Olympics aim to promote peace and unity across the globe through sports. Ironically, however, we predicted that the Olympics could be associated with intergroup biases because the Olympics not only activate social/national identity as a citizen, but also highlight intense competition between countries. In support of this prediction, attitudes toward outgroups were negatively associated with international sporting events like the Olympics (Studies 1–2). Moreover, both behavioral intentions (Study 3) and actual behaviors (Study 4) toward outgroups were more negative during the Olympics than before the Olympics. During the Olympics, Koreans were less willing to donate money to help migrant workers and showed a tendency to discriminate against Southeast Asian job applicants. Interestingly, the association was observed for negatively stereotyped outgroups (e.g., Southeast Asians and Chinese), but not for favorably stereotyped outgroups (e.g., Canadians).
Contemporary management of an orthodontic-orthognathic patient with limited time availability in an orthodontic office setting: Case report
Authors: Kau Chung How , Wang Zhendong , Wang Jue , Krishnan Deepak G
Published: June 2020

Introduction:

This case report describes the treatment of a 21-year-old man who presented in an orthodontic office for treatment but lived in a city 100 miles away and wanted the orthognathic surgery in another state in America. The patient presented with an anterior open bite and skeletal Class III relationship.

Methods:

The treatment plan included: (1) effective and careful communication of the treatment plan with the patient, orthodontist and oral and maxillofacial surgeon; (2) pre-surgical alignment and levelling of the teeth in both arches with Invisalign; (3) a long-distance communication between the orthodontist and the surgeon for surgical plan with virtual surgical planning (VSP Orthognathics; 3D Systems, www.3Dsystem.com ) online; (4) maxillary advancement (LeFort I osteotomy) with mandibular set-back (bilateral sagittal split osteotomy); (5) postsurgical correction of the malocclusion with clear brackets and aligners; and (6) retention and final small tooth movement adjustments with aligners/clear retainers.

Results:

The anterior open bite was treated, crowding was eliminated in the upper and lower anterior segment, correction of skeletal and dental Class III malocclusion was obtained, mandibular plane angle was reduced and facial profile improved.

Conclusions:

The results suggest that aesthetic and functional results can be achieved with long-distance communication of two specialties and with the combined use of clear aligners and clear fixed appliances.
Making Thailand’s UHC ‘SAFE’ (sustainable, affordable, fair and efficient)
Authors: Chunharas Somsak
Published: June 2020

Thai UHC has been established through national efforts to learn from international as well as national development of how to build a system-wide financial risk protection for the Thai population while also ensuring effective coverage of health services. One of the key strategic approach is establishing a strategic purchasing organization called national health security office (NHSO) since 2002. Many lesson have been learnt and shared here hoping that they are generic enough to guide actions and policy decisions either for countries starting UHC or those who have had some models going on. For example, a professionally run strategic purchasing body with certain degree of autonomy is key but the needs to harmonize multiple schemes are also challenging, technically as well as politically. The effective use of and support for existing public sector health services systems is another key lesson. The challenge of making the systems sustainable, affordable fair and efficient have been with us since the very beginning and we shares some of the approaches to address this issue to ensure that UHC will be properly supported politically, professionally managed while maintaining a well balanced demand side with the view to ensure that UHC is creating better health and not merely more access to services.
Semi-physical state and parameter estimation of diesel combustion phases for real-time applications
Authors: Weber Alexander , Isermann Rolf
Published: June 2020

A model-based methodology is presented, which allows the estimation of the characteristic phases of diesel combustion using a semi-physical model approach combined with state and parameter estimation through extended Kalman filtering. The physical relation between the fuel injection and the characteristic diesel combustion phases, such as premixed, diffusive combustion and burn-out, are modeled separately by linear dynamic transfer functions formulated in crank angle frequency domain and transformed into state space representation. The resulting state variables are the released burning energy and its derivatives of each combustion phase. Associated crank angle constants determine the dynamics of the combustion phases and represent the rate parameters to be estimated. By incorporating further physical assumptions regarding the fuel path and air–fuel-mixing dynamics, the combustion phase parameters are estimated online for each working cycle. Cylinder pressure signals and online combustion analysis are used to determine the burn rate of the diesel engine at the test bench. Investigations have shown that the estimated rate parameters depend on the current engine operation point. They are estimated during measurements and stored in lookup tables through an online-learning method based on a fast recursive least squares estimation algorithm.
When access is denied: Conducting an interview through letter writing
Authors: Burtt Emma
Published: June 2020

Access to prisons in England and Wales is becoming ever more restricted to researchers and all projects must have sufficient links to Her Majesty’s Prison and Probation Service (HMPPS) priorities to be considered. What are the alternatives when there is no such link or when access has otherwise been denied? This article focuses on one possible solution – conducting a qualitative interview via letter.

Drawing on my own experience of conducting such interviews with prisoners maintaining innocence, I document how the method can work in practice. Although not without difficulty, written interviews are capable of producing rich, qualitative data and provide benefits to both the researcher and researched when compared to traditional face-to-face interviews. I ultimately demonstrate how interviews via letter offer a valuable alternative when interacting with people, not only in prison but across all secure estates.
Systematic Review and Meta-Analysis on Acute Stress Disorder: Rates Following Different Types of Traumatic Events
Authors: Geoffrion Steve , Goncalves Jane , Robichaud Isabelle , Sader Josette , Giguère Charles-Édouard , Fortin Maxime , Lamothe Josianne , Bernard Paquito , Guay Stéphane
Published: June 2020

Studies investigating rates of acute stress disorder following exposure to a traumatic event report widely varying results, even when examining the same types of traumatic events. The first purpose of this systematic review and meta-analysis was to describe rates of acute stress disorder following five different types of traumatic events. The second goal was to assess the methodological and trauma-related factors influencing these rates. Between May 2017 and October 2019, studies were identified by searching through the PsychINFO, PubMed/Medline, OVID, CINAHL, Scopus, and PILOTS databases. Records were included if (1) participants were 16 years old and over, (2) the assessment was completed within 30 days of the event, (3) a standardized assessment instrument was utilized, (4) the type of traumatic event was specified, and (5) the acute stress disorder rate was reported. The list of traumatic events used for the search strategy was based on the Diagnostic and Statistical Manual of Mental Disorders and was complemented by those listed in the Life Events Checklist and the National Comorbidity Survey Replication. Seventy-three samples from 70 studies totaling 20,065 participants met inclusion criteria. Results revealed that rates of acute stress disorder ranged from 14.1% for war-related trauma to 36.0% for interpersonal trauma. Interpersonal trauma was significantly more likely to lead to acute stress disorder than other types of events, except for disaster-related trauma. Differing assessment instruments, types of exposure and geographical locations, and the intentional nature of certain events contributed to heterogeneity in rates within each type of traumatic event.
The Effectiveness of Educational Interventions on Traditional Bullying and Cyberbullying Among Adolescents: A Systematic Review and Meta-Analysis
Authors: Ng Esperanza Debby , Chua Joelle Yan Xin , Shorey Shefaly
Published: June 2020

In consideration of the adverse societal, physical, and psychological impacts of bullying on a child’s development and future, many studies have developed anti-bullying programs and educational interventions to curb bullying occurrences. Therefore, this systematic review aimed to examine the effectiveness of such educational interventions at reducing the frequencies of traditional bullying or cyberbullying and cybervictimization among adolescents. A comprehensive search was conducted using PubMed, Embase, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, Google Scholar, and ProQuest Dissertations and Theses. Only quantitative studies that reported the effects of educational interventions on reducing the frequencies of traditional bullying or cyberbullying victimization and perpetration were included. Seventeen studies ( Ntotal = 35,694 adolescents, Rangechild age = 10–18 years) were finalized, and meta-analyses were conducted using a random effect model. Overall, the existing educational interventions had very small to small effect sizes on traditional bullying and cyberbullying perpetration (traditional: standardized mean differences [SMD] = −.30 and cyber: SMD = −.16) and victimization (traditional: SMD = −18 and cyber: SMD = −.13) among adolescents. Type of intervention (i.e., whole school–based or classroom-based), program duration, and presence of parental involvement did not moderate program effectiveness, but cyberbullying programs were more effective when delivered by technology-savvy content experts compared to teachers. Since existing educational interventions were marginally effective in reducing bullying frequencies, further research is needed to identify key moderators that enhance educational programs or develop alternative forms of anti-bullying interventions.
Informed Clustering of Donation Service Areas for Improved Benchmarking
Authors: Noreen Samantha M. , Rosendale John , Carrico Robert J.
Published: June 2020

The donation community continuously strives to collaborate and share effective practices to further the mission of saving and healing lives. Donation service areas in which the Organ Procurement Organizations (OPOs) work are multifaceted in their demographics, inciting the Organ Procurement and Transplantation Network to consider a more holistic and objective measure of similarity rather than the size of population alone or locational proximity alone. This would allow OPOs, as a part of their quality improvement efforts, to learn from and mentor other organizations that are dealing with similar challenges. By incorporating multiple informative characteristics together, we can distinguish those likenesses only revealed by taking into account multiple factors simultaneously. We used statistical approaches that take many characteristics of interest describing a donation service area and purposely excluded performance measures that an OPO may be able to influence by their own practices. Unsupervised learning methods combined the original characteristics into a smaller number of new variables, eliminating correlation and overlap in information from the original characteristics, and clustered donation service areas based on the general characteristics and population of the area. This analysis is a first step in providing a different perspective for OPOs to learn from other organizations that may face similar challenges, as well as to share best practices and open new lines of communication.
MiR-222-3p Promotes Cell Proliferation and Inhibits Apoptosis by Targeting PUMA (BBC3) in Non-Small Cell Lung Cancer
Authors: Chen Weijun , Li Xiaobo
Published: June 2020

MicroRNAs have been demonstrated to be critical regulators in tumor progression, including non-small cell lung cancer. MicroRNA-222-3p has been reported to function as a tumor suppressor or oncogene in several types of cancer, but its function role in non-small cell lung cancer has not been uncovered. In this study, we first found the expression of microRNA-222-3p was significantly increased in non-small cell lung cancer tissues and cell lines. MicroRNA-222-3p inhibitor decreased the activity of non-small cell lung cancer cells to proliferate and increased cell apoptosis using cell counting kit-8, flow cytometry, and caspase-3 activity analysis. Overexpressed microRNA-222-3p in non-small cell lung cancer cells promoted cell proliferation, but decreased cell apoptosis. Moreover, Bcl-2-binding component 3 was the target gene of microRNA-222-3p, and its knockdown weakened the regulatory effect of microRNA-222-3p inhibitor on cell proliferation and apoptosis in non-small cell lung cancer cells. In conclusion, microRNA-222-3p plays a significant role in the regulation of Bcl-2-binding component 3 expression and might be a promising target for clinical non-small cell lung cancer therapy.
MiR-590 Suppresses Proliferation and Induces Apoptosis in Pancreatic Cancer by Targeting High Mobility Group A2
Authors: Wang Ya-Dong , Mao Jia-Ding , Wang Jun-Feng , Xu Mao-Qi
Published: June 2020

Background:

Pancreatic ductal adenocarcinoma is a common malignancy with high morbidity. MicroRNAs have been demonstrated to be critical posttranscriptional regulators in tumorigenesis. This study aimed to investigate the effect of microRNA-590 on the proliferation and apoptosis of pancreatic ductal adenocarcinoma.

Material and Methods:

The expression of microRNA-590 and high mobility group AT-hook 2 were examined in clinical pancreatic ductal adenocarcinoma tissues. Pancreatic ductal adenocarcinoma cell line Capan-2 was employed and transfected with microRNA-590 mimics or inhibitor. The correlation between microRNA-590 and high mobility group AT-hook 2 was verified by luciferase reporter assay. Cell viability and apoptosis were detected by MTT and flow cytometry assay. The protein level of high mobility group AT-hook 2, AKT, p-AKT, mTOR, and phosphorylated mTOR were analyzed by Western blotting.

Results:

MicroRNA-590 was found to be negatively correlated with the expression of high mobility group AT-hook 2 in pancreatic ductal adenocarcinoma tissues. Further studies identified high mobility group AT-hook 2 as a direct target of microRNA-590. Moreover, overexpression of microRNA-590 downregulated expression of high mobility group AT-hook 2, reduced cell viability, and promoted cell apoptosis, while knockdown of miR-590 led to an inverse result. MicroRNA-590 also suppressed the phosphorylation of AKT and mTOR without altering total AKT and mTOR levels.

Conclusion:

Our study indicated that microRNA-590 negatively regulates the expression of high mobility group AT-hook 2 in clinical specimens and in vitro. MicroRNA-590 can inhibit cell proliferation and induce cell apoptosis in pancreatic ductal adenocarcinoma cells. This regulatory effect of microRNA-590 may be associated with AKT signaling pathway. Therefore, microRNA-590 has the potential to be used as a biomarker for predicting the progression of pancreatic ductal adenocarcinoma.
DCK is an Unfavorable Prognostic Biomarker and Correlated With Immune Infiltrates in Liver Cancer
Authors: Hu Shu Fang , Lin Xia , Xu Lv Ping , Chen Hong Gang , Guo Ju Feng , Jin Li
Published: June 2020

Background:

The biological function of deoxycytidine kinase in tumor is not yet clear, and there are a few studies relating to the correlation of deoxycytidine kinase gene with the occurrence and development of liver cancer.

Methods:

The messenger RNA expression of deoxycytidine kinase was analyzed with the use of the UALCAN and GEPIA database. Moreover, we assessed the function of deoxycytidine kinase on clinical prognosis with Kaplan-Meier plotter database. The relationship between deoxycytidine kinase and cancer immune infiltrates was investigated via Tumor Immune Estimation Resource site. Furthermore, Tumor Immune Estimation Resource was also used to evaluate the correlations between the expression of deoxycytidine kinase and gene marker sets of immune infiltrates.

Results:

The deoxycytidine kinase messenger RNA level significantly upregulated in patients with liver cancer compared to normal liver samples. Moreover, the increased expression of deoxycytidine kinase messenger RNA was closely associated with reduced overall survival and disease-free survival in all liver cancers. In addition, deoxycytidine kinase expression displayed a strong correlation with infiltrating levels of macrophages, neutrophils, and dendritic cells in liver cancer, and deoxycytidine kinase expression was positively correlated with diverse immune marker sets in liver cancer.

Conclusions:

All the above findings suggested that increased expression of deoxycytidine kinase was significantly related to unfavorable prognosis in patients with liver cancer. And deoxycytidine kinase is correlated with immune infiltrating levels, including those of B cells, macrophages, neutrophils, and dendritic cells in patients with liver cancer. These findings suggest that deoxycytidine kinase can be used as a prognostic biomarker for determining prognosis and immune infiltration in liver cancer. And deoxycytidine kinase is a potential target for liver cancer therapy, and these preliminary findings require further study to determine whether deoxycytidine kinase-targeting reagents might be developed for clinical application in liver cancer.
Violent Injuries Among College Students in China: An Exploration of Gender Mental Stress Model
Authors: Yang Tingzhong , Wang Huihui , Zhang Weifang , Fu Jialu , Zhou Huan , Yu Lingwei , Peng Sihui , Cottrell Randall R.
Published: June 2020

The purpose of this study was to explore the gender-specific mental stress model of violent injuries among Chinese college students. A cross-sectional, multistage sampling process was employed to recruit a total of 5025 college students from 22 universities in China. Survey respondents reported their exposure to violent injuries and noted individual and environmental factors that could relate to violent injuries. Both unadjusted and adjusted statistical methods were used to examine the relationships between selected individual and environmental variables with violent injuries among male and female college students. The overall prevalence of violent injuries among male and female college students in this study was 4.40% (95% CI [0.10%, 7.80%]) and 5.20% (95% CI [0.05%, 10.35%]). The study found that higher mental stress (OR: 3.32), lower level universities (OR: 5.99), and family location in rural areas (OR: 4.00) were associated with a higher likelihood of violent injuries, and mothers employed as professionals (OR: 0.07) was associated with lower prevalence of violent injuries among male students. Unlike male students, mental stress and mothers’ occupation were not associated with violent injuries among female students. University type was also associated with violent injuries but this association was inverted (OR: 0.06) among female students. This study found gender-specific relationships affecting violent injuries among college students in China. Prevention strategies need to be developed in consideration of gender influences and should be enacted to reduce the negative impact of violent injuries on society and personal health in China.
Men’s Health-Related Magazines: A Retrospective Study of What They Recommend and the Evidence Addressing Their Recommendations
Authors: Jalloh Mohamed A. , Barnett Mitchell J. , Ip Eric J.
Published: June 2020

Magazines have traditionally been an effective medium for delivering health media messages to large populations or specific groups. In this retrospective cross-sectional study, we evaluated nine issues from 2016 publications of American men’s health-related magazines ( Men’s Health and Men’s Fitness) to evaluate their recommendations and determine their validity by examining corresponding evidence found in the peer-reviewed scientific literature. We extracted health recommendations ( n = 161) from both magazines and independently searched and evaluated evidence addressing the recommendations. We could find at least a case study or higher quality evidence addressing only 42% of the 161 recommendations (80 recommendations from Men’s Health and 81 recommendations from Men’s Fitness). For recommendations from Men’s Health, evidence supported approximately 23% of the 80 recommendations, while evidence was unclear, nonexistent, or contradictory for approximately 77% of the recommendations. For recommendations from Men’s Fitness, evidence supported approximately 25% of the 81 recommendations, while evidence was unclear, nonexistent, or contradictory for approximately 75% of the recommendations. The majority of recommendations made in men’s health-related magazines appear to lack credible peer-reviewed evidence; therefore, patients should discuss such recommendations with health-care providers before implementing.
Prognostic Role of IL-18 in Various Human Cancers and Radiation Injuries: A Meta-Analysis
Authors: Yao Zhen , Zhao Minyan , Gao Guangyu , Yang Jiawen , Wang Zhenzhen , Liu Yulong
Published: June 2020

Background:

In recent years, more and more studies have shown that various inflammatory factors have predictive effects on the prognosis of various human tumors. However, the prognostic role of interleukin 18 (IL-18) remains controversial. Furthermore, its role in radiation-induced injuries relating to radiotherapy (RT) is also unclear. In this study, we conducted the meta-analysis to clarify its roles in prognosis of human tumors and radiation-induced injuries relating to RT.

Methods:

We comprehensively searched PubMed, Embase, and Cochrane Library to identify studies published before November 2019 involving patients with cancer expressing IL-18 and which reported overall survival (OS) during the follow-up period.

Results:

A total of 1376 samples from 16 studies showed that high expression of IL-18 is closely related to prognosis and OS for patients with carcinoma (hazard ratio [HR]: 2.12; 95% CI: 1.81-2.49; P = .04; random-effect model). In addition, subgroup analysis proved that high expression of IL-18 was related to poor OS of hematologic tumor (HR: 2.03, 95% CI: 1.44-2.86, P < .00001), hepatocellular carcinoma (HR: 1.99, 95% CI: 1.38-2.86, P = .0002), and gastric cancer (HR: 2.00, 95% CI: 1.12-3.57, P = .02).

Conclusions:

High expression of IL-18 is related with poor prognosis of carcinoma.
The Protective Effect of Adenosine-Preconditioning on Paraquat-Induced Damage inCaenorhabditis elegans
Authors: Xie Xin , Shang Liangcheng , Ye Sudan , Chen Chun
Published: June 2020

Adenosine plays an important role in the physiological and pathological conditions of the body by combining different types of adenosine receptors widely distributed in various tissues in the body. In present study, an acute model for paraquat-poisoning in Caenorhabditis elegans was established for quantitative assessment via a time-dose-mortality (TDM) modeling technique with various paraquat doses over 8 hours. Adenosine was first used to precondition at high, medium, and low concentrations and the survival rate of C. elegans was recorded to evaluate adenosine antistress protection against paraquat damage. The results revealed that the TDM model was good for the quantitative assessment of paraquat-poisoning on C. elegans based on the Hosmer-Lemeshow test for homogeneity of modeling ( P = .38). The survival rates of adenosine-preconditioned C. elegans have a dose-dependent association with adenosine concentration. At 3000 μM (high concentration) and 300 μM (medium concentration), adenosine-preconditioned C. elegans still had survival rates of 5.38% ± 1.68% and 5.0% ± 1.19% in the subsequent 8 hours observation period. On the contrary, the survival rates of those receiving 30 μM (low concentration) and the 0 μM (unpreconditioned treatment) were zero. To conclude, adenosine preconditioning had protective effects on C. elegans intoxicated with paraquat by decreasing its mortality rate.
Systemic lupus erythematosus diagnosis impacts clinical outcomes of arteriovenous fistulas in comparison to other end-stage renal disease etiologies
Authors: Cuen-Ojeda Cesar , Pascual-Ramos Virginia , Contreras-Yáñez Irazú , Anaya-Ayala Javier E , Elenes-Sanchez Erika , Rosas-Rios Casandra , Mendez-Sosa Miguel A , Lozano-Corona Rodrigo , Hinojosa Carlos A
Published: June 2020

Objectives

Arteriovenous fistulas primary patency at one-year occurs in 43–85% of the patients with end-stage renal disease. The diagnosis attributable to end-stage renal disease has been suggested to impact arteriovenous fistulas outcomes. The objective was to compare primary patency at one week, 1, 3, 6, and 12 months of follow-ups, among systemic lupus erythematosus patients and two control groups; additionally, we evaluated the impact of systemic lupus erythematosus to predict early patency loss.

Methods

A retrospective review of charts from arteriovenous fistulas created between 2008 and 2017 was performed. One-hundred thirty-four patients were identified and classified according to end-stage renal disease attributable diagnosis as: systemic lupus erythematosus cases ( N = 14), control-group-1 (91 patients with primarily diabetes and hypertension), and control-group-2 (29 patients with idiopathic end-stage renal disease). A case–control matched design (1:2:1) was proposed. Logistic regression analysis and Kaplan–Meier curves were used. Institutional Review Board approval was obtained.

Results

More systemic lupus erythematosus patients lost primary patency at 3 (28.6%) and 12 months (71.4%) than patients from control-groups-1 (vs. 3.6% and 35.7%, respectively) and -2 (vs. 0% and 14.3%, respectively), ( p ≤ 0.011 for both). Days of primary patency survival were shorter in systemic lupus erythematosus patients ( p = 0.003). Systemic lupus erythematosus diagnosis was the only factor associated with early patency loss, HR: 3.141, 95%CI: 1.161–8.493 (systemic lupus erythematosus diagnosis vs. control-group-1) and HR: 12.582, 95%CI: 1.582–100.035 (systemic lupus erythematosus diagnosis vs. control-group-2).

Conclusions

Diagnosis attributable to end-stage renal disease has a major impact on arteriovenous fistula outcomes in patients. Systemic lupus erythematosus patients have an increased risk of arteriovenous fistulas patency loss within the first six months of follow-up. Patients with idiopathic end-stage renal disease had an excellent one year arteriovenous fistula patency survival.