bluuebunny/crossref_metadata_2025 huggingface dataset:
THE STRUCTURAL ANALYSIS OF THE HOUSING OF THE FREIGHT CAR AXLE BOX
Authors: Martynov I. , Trufanova A. , Shovkun V. , Sharyi O.
Published: April 2023

The cars that are operated on the railways of Ukraine are equipped with axle boxes with cylindrical roller bearings. Many years of operating experience has shown that they have insufficient durability. One of the reasons is the uneven distribution of the load between the rollers in the bearings, caused by the design features of the wagon bogies.
One of the possible ways to equalize the distribution of loads between the rolling elements can be the creation of a box housing with variable stiffness. The article provides a detailed analysis of existing design solutions. It has been established that the use of aluminum alloys for the manufacture of axle box housings, despite the low specific density of the alloy, is impractical due to their high cost, increased wear of the bearing surfaces, and insufficient service life. The use of rubber as gaskets to create variable stiffness also proved to be impractical. The reason is the inability of rubber to operate at low temperatures in winter. As a result, the destruction of the rubber required additional (unscheduled) axle box repairs.
The manufacture of axle box bodies with cavities or grooves of various configurations in order to change the rigidity of the elements of the upper part of the axle box body turned out to be unpromising. The reason was the technological complexity of manufacturing, the difficulty of providing the necessary strength under dynamic loading conditions.
The most successful was the design of the box body with two rectangular tides along the edges of the upper part in the roller loading zone. These lugs are located along the entire length of the hull and are the supporting surfaces for transferring the load from the side frame.
A promising direction in the 70s of the XX century was the rejection of traditional massive axle boxes and the transition to the use of adapters (half axle boxes). However, this option had to be abandoned at that time due to the impossibility of ensuring reliable sealing of the bearings.
At the same time, the modern experience of American railways shows that one of the promising areas for improving the design of roller axle boxes is the use of adapters in freight bogies of wheelsets equipped with cassette bearings. The adapter redistributes the load from the bogie to the cassette bearing, acts as a supporting part of a conventional axle box and limits the longitudinal, transverse and angular shifts of the wheel set relative to the bogie frame. In addition, the adapter allows you to reduce the tare weight of the car. However, the use of adapters is possible only if the bearings themselves are reliably sealed.
Also, a promising direction can be considered the creation of a box body with variable stiffness, including the use of rubber-metal elements.
Keywords: freight car, axle box, housing, bearing, adapter, support surface, actuation.
TRENDS IN THE DEVELOPMENT OF THE URBAN REAL ESTATE MARKET IN UKRAINE
Authors: Denysenko N. , Bondarenko O. , Dovbush V.
Published: April 2023

The volatility of external and internal factors affecting the real estate market makes it necessary to study trends and predict the consequences of management decisions to prevent financial losses.
The real estate market is a sphere of capital investment in real estate and a system of economic relations arising from real estate transactions. These relations arise when buying and selling real estate, leasing real estate, etc.
Depending on the legal framework, external and internal financing conditions, and forms of property ownership, the real estate market is constantly changing and unique to each country, region, and city. To accurately evaluate real estate, it is necessary to monitor in detail all the changes taking place in the market.
This article analyzes the factors that influence the formation of supply and demand in the real estate market. Economic factors have the greatest impact, namely: the level and dynamics of population income; differentiation of the population by income level; level of business development and its dynamics; changes in the structure of the business and its profitability; availability of financial resources; the state of alternative and related markets; prices in the real estate market; rental rates; risks of an investment in real estate; construction costs; prices and tariffs for utilities and energy resources.
Social factors, such as population dynamics and age structure, the social structure of the population, crime rate and trends in crime, also significantly impact real estate market trends.
The interaction of these factors ultimately determines the state and dynamics of supply and demand in the real estate market. At the same time, the direction of their influence may either coincide or differ for supply and demand. This can be better understood by identifying trends in supply and demand and their dependence on these factors.
The article examines the history of price dynamics and systematizes the stages of the formation and development of the real estate market in Ukraine. The state of the real estate market during the crisis periods is analyzed and a forecast for the next year is made.
Keywords: real estate market, real estate market dynamics, demand, offer, investment potential.
FINANCIAL AND ANALITICAL COMPONENT OF THE ECONOMIC SECURITY ENTERPRISES OF THE INDUSTRY OF TOURISM AND HOTEL INDUSTRY
Authors: Illiashenko O. , Lytovchenko O.
Published: April 2023

The article notes that external changes that accompany the development and existence of enterprises of the industry of tourism and hotel industry are often characterized by crisis manifestations, and recent events in Ukraine have sometimes devastating consequences for enterprises. The relevance of the importance of economic security of enterprises of the industry of tourism and hotel industry is proved in this article. Attention is focused on the functional orientation of the economic security of enterprises of the industry of tourism and hotel industry, which is fundamental in its overall structure and allows to distinguish its two important components: financial and analytical. Research shows that the financial component is one of the most important conditions for effective and economically secure management of an enterprise. It includes all available and attracted financial resources of enterprises, ways of managing these resources, their rational use, additional financial opportunities, and other things necessary to ensure a high level of economic security. The financial component of modern enterprises of the industry of tourism and hotel industry is at a rather low level due to many negative factors, such as inflation, rapidly rising exchange rates, lack of sufficient government programs to finance tourism and hospitality enterprises, financial instability of counterparties, low investment activity, etc. The analytical component of economic security of enterprises consists of a large number of analytical methods and techniques which are used to carry out a high-quality analysis of economic security at all levels and spheres of activity of enterprises. The article identifies a separate group of methods, which is called accounting and analytical methods. This group includes methods aimed at forming a clear, high-quality and understandable information space for making managerial decisions on the economic security of enterprises of the industry of tourism and hotel industry. These methods are: balance and reporting analysis, budgeting, benchmarking, break-even analysis, sensitivity analysis, SWOT analysis, JIT system, LIC analysis, VVC method. The article emphasizes that the basis and foundation of economic security of enterprises are financial and analytical components, without which it is impossible to achieve its stable long-term level. High-quality forecasting, timely warning and response measures are becoming a top priority for the management of enterprises of the industry of tourism and hotel industry.
Keywords: economic security, enterprise, tourism, hotel industry, financial component, accounting and analytical component.
THEORETICAL PRINCIPLES OF EXCHANGE TRADING IN THE ASPECT OF DIGITALIZATION
Authors: Dymchenko O. , Smachylo V. , Gnatchenko Y. , Tararuiev Y. , Rudachenko O.
Published: April 2023

The purpose of the article is to determine the main directions of development of modern information technologies in stock trading. The article analyzes the results of scientific publications related to the problems of stock trading in Ukraine and formulates a conclusion about the need for a more thorough study of the problems of applying artificial intelligence in this area. The main technologies used in stock trading are characterized. Modern systems and technologies that were developed to facilitate stock trading are highlighted, namely: electronic trading platforms; high-frequency trading; Artificial Intelligence; blockchain; cloud technologies; social media. The main stages of the application of Artificial Intelligence in stock trading are described, with the definition of its main functions. The prospects of using digital platforms for stock exchange transactions are analyzed. Digital platforms have been proven to be a key component of digital business transformation, creating an online space for business, consumers and financial transactions and interactions. The advantages of digital platforms are ease of use, visual appeal, a combination of integrated analytics and personalized solutions. Digital currencies linked to platforms will become more differentiated than conventional currencies today, differing not only in their monetary functions but also in the functionality provided by the linked platforms. The economy of digital platforms has a positive effect on stock trading and currency competition. A comparison of bank-centered and platform-centered financial models in the case of their application for stock exchange transactions was developed. It has been proven that the main advantage of the platform-centric model is the use of Artificial Intelligence for stock trading. In fact, the platform described in the article performs the functions of a broker-consultant for clients, which not only concludes deals, but also generates the best options for them at a certain point in time (which is especially important when taking into account the second price fluctuations of exchange goods).
Keywords: stock market, digitalization, fintech, innovative technologies, business.
RESEARCH OF BUSINESS SUBJECTS AS A PREREQUISITE FOR THEIR DETINIZATION
Authors: Pyskun L.
Published: April 2023

The article is devoted to the definition of the main directions of research of business entities, their qualifications and state of development during the war period, taking into account the prerequisites of their detinization and the detinization of the economy of Ukraine as a whole. Attention is focused on discrepancies in the qualifications of business entities in the legislation of Ukraine. The main qualification criteria of business entities are described.
It was determined that, thus, 1) micro-enterprises are enterprises with a book value of assets up to 350,000 euros, net income from the sale of products (goods, works, services) up to 700,000 euros. EUR, total cumulative income up to EUR 2 million. euros and with an average number of employees up to 10; 2) small enterprises with a book value of assets up to 4 million euros, net income from the sale of products (goods, works, services) up to 8 million euros, a total aggregate income of up to 10 million euros and with an average number of employees up to 50; 3) medium - with a book value of assets up to 20 million euros, net income from the sale of products (goods, works, services) up to 40 million euros, a total aggregate income of up to 50 million euros, an average number of employees up to 250; 4) large: book value of assets over 20 million euros, net income from sales of products (goods, works, services) over 40 million euros, total aggregate income over 50 million euros, average number of employees over 250 people.
A comparative analysis of the number of operating enterprises by types of economic activity was carried out, with a division into large, medium, small and micro enterprises.
Prospects of the research directions have been determined: analysis and adaptation of business entities in war and post-war times; development of a recommendation on the detinization of business entities; as well as the justification of proposals for the implementation of a number of measures, the involvement of non-refundable financial support and technologies for the reconstruction and modernization of enterprises, the provision of affordable loans, the localization of equipment production in the state, etc.
Keywords: shadow economy, detenization of the economy, business entities, qualifications; authorized capital, ownership.
SELECTION AND USE OF PERSONNEL MANAGEMENT TECHNOLOGIES IN HOTEL ENTERPRISES
Authors: Kolontaievskyi O. , Yatsiuk M.
Published: April 2023

The article is aimed at defining the criteria and algorithm for selecting the optimal technologies for the use of personnel management in the hotel enterprise. The main approaches to the definition of the term management technology and staff management technology are analysed. The composition of technologies of target management and process technologies is considered. The features and conditions of use of process management technologies are defined. The advantages and disadvantages of management technologies when used in hotel enterprises are analysed. Recommendations on the use of personnel management technologies in accordance with the working conditions of hotel business enterprises are provided.
The main types of personnel management technologies are listed. Personnel technologies and staff technologies are considered. A system of criteria for choosing the technology of personnel management is proposed. The following are proposed as selection criteria: size of the hotel enterprise, staff qualification, level of automation of production and management processes, degree of management informatisation, readiness for innovations, cost of technology and its popularity, period of introduction and initial testing of technology and the degree of technological maturity of the enterprise in general.
An algorithm for choosing technologies for management of personnel of hotel enterprise has been provided. The formation of a refined list of management technologies recommended for implementation is carried out after selecting the target technology and assessing the level of technological and managerial maturity of the hotel enterprise.
The expediency of adapting the components of the technology of personnel management by functional subsystems is emphasised. The main subsystems are as follows: technology of planning the need for personnel; technology of search, selection and attraction of personnel; technology of placement and accounting of personnel; technology of professional and social development of employees; technology of personnel evaluation; technology of stimulation and motivation of personnel.
Keywords: personnel management, management technology, target management, personnel technologies, HR technologies.
Modificación del maxilar de niños de 8 a 12 años posterior al uso de MARPE. Revisión de literatura
Authors: Kagawa Tenesaca Kiyoko Samantha , Palmas Oscar Sergio
Published: April 2023

Fundamentos: La deficiencia maxilar transversal, se caracteriza por un deficiente crecimiento del maxilar, se encuentra estrechamente asociado con apiñamiento dental, mordida cruzada, maloclusión clase II y clase III y disfunción de la articulación temporomandibular, es así que, la expansión palatina rápida asistida por microtornillos (MARPE) se desarrolló con el propósito de lograr la expansión maxilar sin intervención quirúrgica. Objetivo: Analizar las modificaciones en el maxilar posterior al uso de MARPE en niños de 8 a 12 años.  Métodos: La literatura se seleccionó mediante una búsqueda en las bases de datos electrónicas: Pubmed, Springer, Cochrane Library, Google Academic, Proquest, Web of science, Taylor & Francis. La búsqueda de la información se realizó con temporalidad desde enero del año 2012 a enero del año 2023, con la inclusión de todos los idiomas. Resultados: Después de aplicar los criterios de inclusión en total se obtuvieron y revisaron 16 artículos. Conclusiones: La literatura disponible demostró que MARPE podría reducir la pérdida del espesor óseo alveolar bucal y del nivel óseo marginal en el área de los primeros premolares que la expansión rápida palatal convencional. Sin embargo, la baja calidad de la evidencia, hacen que estas afirmaciones no sean concluyentes. Por lo que, se alienta a los investigadores a realizar nuevos estudios, de preferencia estudios que utilicen muestras significativas y con una duración de seguimiento más prolongado para identificar cuáles son los efectos a largo plazo y su recidiva.
Impacto del COVID-19 en el comercio agropecuario, alternativas y planes de acción
Authors: Cobos Mora Fernando , Hasang Moran Edwin , Gómez Villalva Juan , Cornejo Ortiz Jackson
Published: April 2023

Sabemos que el desarrollo agropecuario constituye uno de los medios más importantes para poner fin a la pobreza extrema, impulsar la prosperidad y alimentar a una población que para el 2050 se espera llegue a 9,700 millones de habitantes; lamentablemente el sector agropecuario durante el COVID-19 ha sido afectado internacionalmente, repercutiendo en todas sus actividades. Este artículo presenta información, de cómo el COVID-19 ha impactado sobre la cadena de valor que conforma la actividad agropecuaria, siendo esta la base de la alimentación de la población y que genera ingresos a pequeños, medianos y grandes agricultores, los cuales contribuyen a la seguridad alimentaria del mundo. El presente estudio es una revisión documental de tipo descriptivo, basada en aportes teóricos de artículos científicos y publicaciones oficiales de dominio público de instituciones académicas, tecnológicas, científicas y gubernamentales, cuyo objetivo fue analizar la situación actual del sector agropecuario frente a la emergencia sanitaria COVID-19. Como conclusión se determinó que el COVID-19, generó impactos sobre el comercio agropecuario y la seguridad alimentaria, lo cual obligo a muchas de las empresas adaptarse a las preocupaciones de los clientes y adoptar la transformación digital como estrategia para potencializar su desempeño comercial.
Elucidation of Effectiveness of Dye Absorption as a Probe to Determine The Chemical Reactivity of Cellulose Nanofibrils
Authors: Salem Khandoker Samaher , Kasera Nitesh Kumar , Pal Lokendra , Jameel Hasan , Lucia Lucian A
Published: April 2023

Cellulose nanofibrils (CNF) has earned substantial attention as a sustainable biopolymer due to environmental consciousness and the implementation of strict regulations for the remediation of single use plastics. However, the existing processing strategies rely on intensive mechanical grinding and quality of production is often measured by physical changes such as fines which completely overlooks chemical changes such as exposure of large numbers of hydroxyls which significantly compromises desirable properties. Therefore, we use dye absorption technique to measure the chemical reactivity of the CNF. The CNF was produced from bleached hardwood kraft pulp (BHK) with different extent of fibrillation by varying the cumulative mechanical energy and then acetylation and dye absorption were used as a tool to investigate its chemical reactivity. The degree of substitution (DS) of the CNF reached a highest value and subsequently, it decreased to lesser values though the CNF were produced using higher cumulative energies. The dye absorption by CNF samples also followed the similar trend like the DS value of the CNF samples. The dye absorption was affected by the hydration shell formed by the hard-to-remove (HR) water molecules and the self-aggregation of cellulose hydroxyls at higher fibrillation, which hindered accessibility of the dye molecules to absorption cites. Therefore, this technique could be used as a new useful probing tool to determine the nanocellulose reactivity and might be a potential physicochemical strategy to produce and chemically modify CNF in an efficient and sustainable way to optimize its performance for different applications.
DUJASE Vol. 7 (2) 39-46, 2022 (July)
Effect of Tobacco Consumption on Serum Alanine Aminotransferase and Alkaline Phosphatase Levels in Smoking
Authors: Roy Shapna Rani , Sarkar Chandra Rani , Zahid ATM Zoadur Rahim , Ahmed Neaz
Published: April 2023

Background: The use of tobacco has been significantly increased globally in recent decades. Easy availability and the low price gives rise to high consumption of tobacco smoking. Tobacco use is a leading preventable cause of premature mortality and morbidity.. Previous studies described the detrimental effects of tobacco smoking on liver function.
Objectives: To observe the effects of tobacco consumption on the levels of serum alanine aminotransferase and alkaline phosphatase levels in smokers.
Methods: The cross-sectional analytical study was conducted from January 2017 to January 2018 in the department of physiology, Rangpur Medical College, Rangpur. A total number of 60 subjects were selected, among them 30 were apparently healthy non-tobacco chewer non-smoker subjects as control group ( group A) and 30 were apparently healthy smoker non-tobacco chewer subjects ( group B). The subjects were selected from different area of Rangpur city. The effects of cigarette smoking on liver function were studied by measuring the levels of serum alanine aminotransferase and alkaline phosphatase levels. For statistical analysis independent sample “t” test was performed by computer based software SPSS-17.0 version for windows.
Results: Serum alanine aminotransferase and alkaline phosphatase levels were significantly higher (p<0.001) in smoker non-tobacco chewer subjects as compared with the healthy control subjects.
Conclusion: The increased serum alanine aminotransferase and alkaline phosphatase levels in smoker non-tobacco chewer subjects were evidence of development of liver function impairment due to tobacco smoking and this might offer a new preventive approach to liver function impairment in population with tobacco smoking.
J Rang Med Col. March 2023; Vol. 8, No. 1:65-68
RESPON PENGGUNA JALAN TERHADAP KEBERADAAN PASAR KAGET DI JALAN AKSES CIKEAS-CIMANGGIS
Authors: Mulyana Dede , Widodo Pamuji , Cecep Cecep
Published: April 2023

Pasar merupakan salah satu tempat terlaksananya transaski antara penjual dan pembeli, baik dengan pedagang atau petani atau dengan para penjual yang berada di pasar. Di Cikeas-Cimanggis setiap hari minggu terdapat sebuah kegiatan yang rutin dilaksanakan yaitu adanya pasar kaget. Pasar kaget yaitu pasar yang ketersediaannya hanya dalam waktu-waktu tertentu saja dan lokasi keberadaannya tertentu juga yang ramai dengan para pengguna jalan. Ketersediaan pasar kaget yang terletak di akses Cikeas-Cimanggis dimana memiliki dampak langsung terhadap masyarakat sekitar dan juga bagi para pengguna jalan. Tujuan daripada penelitian ini yaitu untuk mengetahui tentang respon masyarakat akan keberadaan pasar kaget di sekitar para pengguna jalan. Penelitian ini menggunakan sebuah metode kualitatif yaitu dengan melakukan survei primer berupa kuisioner, observasi, wawancara, dokumentasi, dan study pustaka. Kesimpulan dalam penelitian ini adalah dimana terdapat respon yang positif dan respon negatif terhadap adanya dan keberadaannya pasar kaget yang berupa antusias dari masyarakat yang membeli kebutuhan dilokasi tersebut. Kata kunci: pasar, pasar kaget, pengguna jalan, respon ABSTRACT The market is one of the places where transactions are carried out between sellers and vendees, either with traders or farmers or with sellers in the market. In Cikeas-Cimanggis every Sunday there is a fray that is routinely carried out, namely the shaped market. So the shaped market is a market where its availability is only at that time and a certain place of existence is also where it is teeming with road users. The availability of the shaped market which is located in the Cikeas-Cimanggis access which has a direct leverage on the peripheral community and also for road users. The expect or purpose of this research is to find out about the response of the surrounding environment to the existence of a shaped market around road users. In this study, a qualitative method was used, define by conducting a primary survey in the form of questionnaires, observations, interviews, documentation and literature study. And the conclusion in this study is where there is a positive response and a negative response to the existence and existence of a shaped market in the form of enthusiasm from the people who buy necessities at that location. Keywords: market, shaped market, response, road users
EXPERIENCE TOUR PADA ERA NEW NORMAL BERBASIS NEOPHILIAN PERSONALITY: PERAN TRAVEL MOTIVES
Authors: Riptiono Sulis , Wibawanto Sigit
Published: April 2023

Penelitian ini bertujuan untuk menguji peran motif perjalanan sebagai mediasi antara kepribadian neophilia dan pengalaman. Penelitian ini melibatkan 182 wisatawan di Kebumen sebagai sampel yang diambil dengan menggunakan tehnik purposive sampling. Data yang terkumpul diolah dengan menggunakan bantuan slat statistic SPSS dan dianalisis dengan menggunakan analisis jalur dan uji sobel. Hasil penelitian menunjukkan bahwa kepribadian neophilia konsumen terbukti berpengaruh positif terhadap motif perjalanan wisatawan dan pengalaman. Hal ini menunjukkan bahwa semua hipotesis yang diuji dalam penelitian ini dinyatakan diterima. Temuan lain juga menunjukkan bahwa motif perjalanan terbukti sebagai pemediasi antara kepribadian neophilian dan pengalaman. Kata kunci: Kebumen, pandemic covid-19, tourism marketing, wisata travel ABSTRACT This study aims to examine the role of travel motives as a mediator between neophilic personality and experience. This study involved 182 tourists in Kebumen as samples taken using purposive sampling technique. The collected data was processed using SPSS statistical slats and analyzed using path analysis and Sobel test. The results showed that the consumer's neophilic personality proved to have a positive effect on tourists' travel motives and experiences. This shows that all the hypotheses tested in this study are accepted. Other findings also suggest that travel motives are shown to mediate between neophilian personality and experience. Keywords: Kebumen, pandemic covid-19, tourism marketing, travelling
ANALISIS BUDAYA KERJA DAN LINGKUNGAN KERJA TERHADAP PRESTASI KERJA PEGAWAI
Authors: Handayani Ris , Laela Siti , Meryati Meryati
Published: April 2023

Penelitian ini dilakukan karena adanya dugaan permasalahan yang ada di Dinas Penanaman Modal dan Pelayanan Terpadu di Depok, Jawa Barat. Penelitian dilakukan  menganalisis apakah ada pengaruh budaya kerja dan lingkungan kerja terhadap prestasi kerja pegawai Dinas Penanaman Modal serta Pelayanan Terpadu Kota Depok. Metode penelitian yang digunakan dengan pendekatan kuantitatif, menggunakan analisis regresi berganda dengan populasi adalah keseluruhan karyawan Dinas Penanaman Modal dan Pelayayan Terpadu yang berjumlah 60 pegawai. Penelitian ini menggunakan teknik total sampling dengan sensus. Populasi diambil secara keseluruhan dijadikan sebagai responden. Hasil penelitian ini menunjukkan hasil  bahwa budaya kerja berpengaruh positif dan signifikan terhadap prestasi kerja pegawai demikian juga dengan hasil lingkungan kerja berpengaruh positif dan signifikan terhadap prestasi kerja. Dapat disimpulkan secara simultan mempunyai pengaruh yang positif di antara variabel independen terhadap variabel dependen. Kata kunci: budaya kerja, lingkungan kerja, prestasi kerja ABSTRACT This research was conducted because of the alleged problems that exist in The Investment and Integrated Service Department in Depok, West Java. The study was conducted to analyze whether there is an influence of work culture and work environment on the work performance of the employees of The Investment Office and Integrated Services in Depok. The research method used is a quantitative approach, using multiple regression analysis, with the population consisting of 60 employees of the integrated investment and service department. This study uses a total sampling technique, with a census. The population is taken as a whole as respondents. The results of this study indicate that work culture has a positive and significant effect on employee performance as well as the results of the work environment having a positive and significant effect on work performance. It can be concluded that simultaneously has a positive influence between the independent variables on the dependent variable. Keywords: work culture, work environment, work performance.
Eficacia de la sentencia no. 66-15-jc/19 de la Corte Constitucional sobre el traslado inmediato de evidencias hidrocarburíferos y su incidencia frente al derecho de la salud
Authors: Viteri-Mero Franklin
Published: April 2023

En el presente artículo se analiza la eficacia de la sentencia No.66-15-JC/19 de la Corte Constitucional, que se pronunció con decisiones judiciales para el traslado inmediato de los productos hidrocarburíferos incautados por la Policía Nacional del Ecuador. Una de estas decisiones refiere principalmente que se deberán establecer los protocolos necesarios que garanticen una adecuada coordinación institucional. También se indica que las evidencias se deberán transportar a lugares adecuados por la Empresa Pública de Hidrocarburos del Ecuador, siendo responsabilidad de estas entidades almacenar en sus centros de acopio las evidencias incautadas de conformidad con la normativa pertinente. Por razones como la cantidad, también tendrán la obligación de transportar y trasladar dichas evidencias. Se destaca que la acumulación de material hidrocarburos en un lugar inadecuado atenta contra el derecho a vivir en un ambiente sano, al buen vivir, al hábitat seguro y contra el derecho a la salud. Este último aspecto es el eje principal del presente trabajo de investigación.
Peningkatan pengetahuan marketplace pada pelaku usaha mikro kecil dan menengah (UMKM) dengan website education marketplace
Authors: Patiro Shine Pintor Siolemba , Aryani Diah , Rekarti Endi , Wibowo Martino
Published: April 2023

Kegiatan Pengabdian Kepada Masyarakat dengan sosialisasi pelatihan-pelatihan marketplace dengan web edukasi marketplace kepada para pelaku Usaha Mikro Kecil dan Menengah (UMKM) di wilayah Jakarta Barat dilaksanakan untuk mendukung upaya pemerintah dalam mendorong akselerasi adopsi teknologi digital bagi UMKM agar mampu beradaptasi dengan perubahan perilaku konsumen di era digital saat ini. Tujuan dari kegiatan ini untuk meningkatkan tingkat pengetahuan dan keterampilan para pelaku UMKM untuk dapat penjualan/pemasaran produknya menggunakan platform marketplace yang ada saat ini. Pada kegiatan pengabdian kepada masyarakat ini dilakukan secara online menggunakan aplikasi zoom dengan metode pelaksanaan terdiri atas 3 tahapan yaitu perencanaan, pelaksanaan dan evaluasi kegiatan sosialisasi pemaparan pelatihan marketplace menggunakan website Edukasi Marketplace kepada 20 peserta UMKM di wilayah Jakarta Barat. Hasil yang diharapkan melalui sosialisasi ini tercapainya peningkatan pengetahuan dan keterampilan para pelaku UMKM melalui pelatihan-pelatihan terkait marketplace pada web edukasi marketplace. Salah satu hasil evaluasi pelaksanaan kegiatan pengabdian kepada masyarakat ini, melalui hasil pengisian kuesioner oleh 20 pelaku UMKM sebagai responden menunjukan bahwa 80% peserta sangat perlu dan 20%% perlu untuk mengikuti pelatihan-pelatihan lanjutan untuk meningkatkan pengetahuan dan kemampuan mereka terkait dengan marketplace. Hasil dari kegiatan ini menghasilkan peningkatan pengetahuan pelaku UMKM dalam menentukan strategi marketing dan menampilkan produk yang menarik minat konsumen di marketplace.
Perancangan Dan Pembuatan Sistem Informasi Rawat Inap Di Rsud Besuki Berbasis Website
Authors: Ulfa Liana
Published: April 2023

Teknologi informasi dapat digunakan untuk memudahkan kegiatan dan mendapatkan keungulan dalam persaingan. RSUD Besuki mengalami permasalahan pada pelaporan sensus rawat inap dan sistem farmasi yang tidak terintegrsi dengan SIMRS. Tujuan dari penelitian ini adalah untuk membuat sistem informasi rawat inap di RSUD Besuki. Teknik pengumpulan data yang digunakan adalah dengan teknik wawancara, observasi dan brainstorming. Jenis penelitian ini adalah kualitatif dengan metode pengembang perangkat lunak prototype yang terdiri dari analisis kebutuhan, pembuatan prototype, evaluasi prototype, pengkodean sistem dan pengujian sistem. Teknik pengujian sistem yang digunakan adalah teknik black box. Hasil dari penelitian ini adalah sistem informasi rawat inap yang sesuai dengan kebutuhan user yang dapat memudahkan dalam pengoalahan data rawat inap sehingga mendapatkan laporan sensus harian rawat inap dan memudahkan pelaporan untuk farmasi. Pada sistem ini terdapat menu terkait pasien masuk rumah sakit, pasien pindah, pasien dipindahkan, pasien keluar rumah sakit, pasien meninggal, hasil perhitungan indikator rumah sakit serta penggunaan obat yang digunakan pada rawat inap.
Klasifikasi Penyakit Tuberculosis (TB) Organ Paru Manusia Berdasarkan Citra Rontgen Thorax Menggunakan Metode Convolutional Neural Network (CNN)
Authors: Rasyid Aulia , Heryawan Lukman
Published: April 2023

Tuberculosis (TB) adalah suatu penyakit infeksi menular yang disebabkan oleh Mycobacterium Tuberculosis dan dapat menyerang berbagai organ dalam tubuh manusia terutama paru-paru. Pemeriksaan diagnosis pada penyakit TB-paru dapat dilakukan dengan melihat keluhan atau gejala klinis pasien, pemeriksaan biakan, pemeriksaan mikroskopis, radiologi ataupun tuberculin test. Selama ini, paramedis mendiagnosis penderita TB tersebut hanya berdasarkan citra rontgen secara manual. Oleh karena itu, diperlukan adanya Artificial Intelligence (AI) untuk membantu dan mempermudah dokter dalam mengklasifikasi penyakit TB paru berdasarkan citra rontgen thorax.Penelitian ini merancang klasifikasi citra x ray penyakit tuberculosis berbasis Convolutional Neural Network (CNN) menggunakan arsitektur MobileNet. Dataset berupa citra X-ray paru yang akan digunakan sebagai masukan untuk proses pengolahan citra atau image processing. Tahapan pertama yaitu input berupa citra X-ray, selanjutnya dilakukan proses preprocessing citra (resizing, grayscale, contrast), dilanjutkan dengan proses segmentation (thresholding), dilanjutkan dengan proses augmentasi data, terakhir citra akan diklasifikasikan menjadi tiga kelas yaitu normal, TBR(tuberculosis bagian kanan), TBRL (tuberculosis bagian kanan dan kiri). Tuberculosis bagian kiri tidak masuk kedalam klasifikasi dikarenakan tuberculosis lebih cenderung terkena pada bagian kanan atau di kedua bagian.Dalam penelitian ini dilakukan pengujian terhadap pengaruh citra ( tanpa image processing , preprocessing dan segmentation) , pengaruh batch size ,pengaruh variasi epoch, pengaruh augmentasi dan perbandingan terhadap performa klasifikasi. Hasil akhir dari penelitian ini menunjukan optimizer terbaik yaitu Adam menggunakan preprocessing CLAHE pada epoch 50 batch size 32 dan menghasilkan nilai akurasi validasi sebesar accuracy sebesar 96.837%, precision 95%, recall 93%, F-1 score sebesar 93%,Â  dan loss sebesar 0.210.
Visualisasi Data Mining Dalam Skrining Covid-19 Berskala Internal Pada Instansi Dengan Metode Classification Tree
Authors: Muslim Muhammad , Windarti Syamsu
Published: April 2023

Penerapan skrining berskala internal pada suatu instansi merupakan masalah baru yang timbul dimasa pandemi covid-19 seperti sekarang. Digital skrining dilakukan guna mempermudah merekam mobilitas para pegawai suatu instansi, namun terkendala oleh data yang dihasilkan masih berbentuk data mentah atau meta-data. Maka dari itu dibutuhkan sebuah tools tambahan yang mampu memvisualkan data sesuai kebutuhan. Sehingga digunakan metode classification tree dengan data mining untuk memvisualkan data skrining. Adapun hasil yang didapatkan berupa rekap mobilitas pegawai instansi terkait riwayat perjalan baik menerapkan prokes ataupun tidak, didapatkan data perjalanan di daerah kota jogja, bantul, kulon progo dan sekitarnya.
An enhanced fractal self-pumping dressing with continuous drainage for accelerated burn wound healing
Authors: Lan Jinze , Shi Lianxin , Xiao Wuyi , Zhang Xiaobin , Wang Yuzhe , Wang Shutao
Published: April 2023

Massive exudates oversecreted from burn wounds always delay the healing process, accompanied by undesired adhesion, continuous inflammation, and high infection risk. Conventional dressings with limited draining ability cannot effectively remove the excessive exudates but constrain them in the wetted dressings immersing the wound bed. Herein, we fabricate an enhanced fractal self-pumping dressing by floating and accumulating hollow glass microspheres in the hydrogel precursor, that can continuously drain water at a non-declining high speed and effectively promote burn wound healing. Small hollow glass microspheres can split the fractal microchannels into smaller ones with higher fractal dimensions, resulting in higher absorption efficiency. In an in vivo burn wound model on the dorsum of murine, the enhanced fractal self-pumping dressing can significantly reduce the appearance of the wound area and alleviate tissue edema along the healing process. This study sheds light on designing high-efficiency and continuous-draining dressings for clinical applications.
Single-cell RNA sequencing analysis of human chondrocytes reveals cell–cell communication alterations mediated by interactive signaling pathways in osteoarthritis
Authors: Kang Xin , Zhang Kailiang , Wang Yakang , Zhao Yang , Lu Yao
Published: April 2023

Objective: Osteoarthritis (OA) is a common joint disorder characterized by degenerative articular cartilage, subchondral bone remodeling, and inflammation. Increasing evidence suggests that the substantial crosstalk between cartilage and synovium is closely related to Osteoarthritis development, but the events that cause this degeneration remain unknown. This study aimed to explore the alterations in intercellular communication involved in the pathogenesis of Osteoarthritis using bioinformatics analysis.

Methods: Single-cell transcriptome sequencing (scRNA-seq) profiles derived from articular cartilage tissue of patients with Osteoarthritis were downloaded from a public database. Chondrocyte heterogeneity was assessed using computational analysis, and cell type identification and clustering analysis were performed using the “FindClusters” function in the Seurat package. Intercellular communication networks, including major signaling inputs and outputs for cells, were predicted, and analyzed using CellChat.

Results: Seven molecularly defined chondrocytes clusters (homeostatic chondrocytes, hypertrophic chondrocyte (HTC), pre-HTC, regulatory chondrocytes, fibro-chondrocytes (FC), pre-FC, and reparative chondrocyte) with different compositions were identified in the damaged cartilage. Compared to those in the intact cartilage, the overall cell–cell communication frequency and communication strength were remarkably increased in the damaged cartilage. The cellular communication among chondrocyte subtypes mediated by signaling pathways, such as PTN, VISFATIN, SPP1, and TGF-β, was selectively altered in Osteoarthritis. Moreover, we verified that SPP1 pathway enrichment scores increased, but VISFATIN pathway enrichment scores decreased based on the bulk rna-seq datasets in Osteoarthritis.

Conclusion: Our results revealed alterations in cell–cell communication among OA-related chondrocyte subtypes that were mediated by specific signaling pathways, which might be a crucial underlying mechanism associated with Osteoarthritis progression.
Colloidal silica as a grouting material for the temporary encapsulation of heat-generating radioactive waste during removal and transport operations: A proof of concept
Authors: Pagano Arianna Gea , El Mountassir Gráinne , Lunn Rebecca Jane
Published: April 2023

Hazardous nuclear waste is produced at all stages during the nuclear fuel cycle. The removal operations of nuclear waste from nuclear reactors and/or storage facilities, such as spent fuel pools and storage silos, pose a hazard for the workforce and the environment, due to the potential release of radioactive particulates, and loss of radioactive debris. The development of innovative techniques to address this issue is desirable. A potential technology to inhibit particulate release during nuclear waste removal and transport operations is colloidal silica grouting. Colloidal silica is an aqueous suspension of silica (SiO2) nanoparticles, able to provide immobilisation of particulates within a hydrogel matrix. In this study, an experimental investigation was carried out to simulate colloidal silica grouting operations around objects at temperatures of 60°C and 120°C, to simulate radioactive waste in standard storage conditions, and during loss of cooling/loss of coolant accident scenarios. The results of the experimental campaign confirm the suitability of colloidal silica to safely remove and transport heat-generating radioactive waste. Critical parameters for designing the silica grout mix, in order to optimise the performance of the hydrogel upon exposure to temperature in different scenarios, are identified and discussed.
Ocean acidification alters the benthic biofilm communities in intertidal soft sediments
Authors: Zhai Chuan , Liang Yantao , Yu Hao , Ji Yan , Chen Xuechao , Wang Min , McMinn Andrew
Published: April 2023

Microphytobenthos (MPB) and bacterial biofilms play crucial roles in primary and secondary production, nutrient cycling and invertebrate settlement in coastal ecosystems, yet little is known of the effects of ocean acidification (OA) on these communities in intertidal soft sediments. To fill in this gap, a 28-day CO2 enhancement experiment was conducted for the benthic biofilms in soft intertidal sediments (muds and sands) from Qingdao, China. This experiment included three CO2 treatments: 400 ppm CO2 (control), 700 ppm CO2 and 1000 ppm CO2 (IPCC predicted value in 2100), which were established in a three-level CO2 incubator that can adjust the CO2 concentration in the overlying air. The effects of OA on benthic biofilms were assessed in the following three aspects: MPB biomass, biofilm community structure and microbial biogeochemical cycling (e.g., C-cycle, N-cycle and S-cycle). This study found that the 700 ppm CO2 treatment did not significantly affect the benthic biofilms in intertidal soft sediments, but the 1000 ppm CO2 treatment significantly altered the biofilm community composition and potentially their role in microbial biogeochemical cyc\ling in sediments (especially in sandy sediments). For the bacterial community in biofilms, the 1000 ppm CO2 enhancement increased the relative abundance of Alteromonadales and Bacillales but decreased the relative abundance of Rhodobacterales and Flavobacteriales. For microbial biogeochemical cycling, the 1000 ppm CO2 treatment enhanced the potential of chemoheterotrophic activity, nitrate reduction and sulfur respiration in sediments, likely resulting in a more stressful environment (hypoxic and enriched H2S) for most benthic organisms. Even though incubations in this study were only 28 days long and thus couldn’t fully accommodate the range of longer-term adaptions, it still suggests that benthic biofilms in intertidal sandy sediments are likely to change significantly near the end of the century if anthropogenic CO2 emissions unmitigated, with profound implications on local ecosystems and biogeochemical cycling.
LZM008, a proposed tocilizumab biosimilar: Pharmacokinetics, safety, and immunogenicity profiles compared with ACTEMRA® in Chinese healthy male subjects
Authors: Cao Guoying , Wang Jingjing , He Jinjie , Hu Yingying , Yang Haijing , Que Linling , Gu Xianghong , Yu Jicheng , Wu Xiaojie , Wu Jufang , Fang Wei , He Qing , Zhang Jing
Published: April 2023

Background: This study aimed to investigate the pharmacokinetics, safety, and immunogenicity of recombinant humanized anti-human IL-6R monoclonal antibody injection, LZM008, and evaluate the pharmacokinetic similarity between LZM008 and tocilizumab (ACTEMRA®) in Chinese healthy male subjects.

Research design and methods: In this randomized, double-blinded, paralleled, two-center Phase I clinical trial, 96 subjects were randomized with a 1:1 ratio to receive 4 mg/kg intravenous dose of LZM008 or ACTEMRA® and evaluated for 28 days. The pharmacokinetic bioequivalence was assessed by the maximum serum concentration (Cmax), the area under the serum concentration–time curve (AUC) from time 0 to the last detectable drug concentration (AUC0-t), and AUC0-∞. The statistical analysis was conducted using SAS Enterprise Guide statistical software. Safety was assessed by physical examinations, vital signs, laboratory tests, and electrocardiograms. Anti-drug antibodies (ADAs) were measured by a bridged electrochemiluminescence immunoassay.

Results: LZM008 (N = 49) and ACTEMRA® (N = 47) groups showed similar pharmacokinetic properties. After a single intravenous infusion of 4 mg/kg LZM008, the Cmax and AUC0-∞ values of LZM008 reached 87.99 μg/mL and 11,526.70 h*μg/mL, respectively, with Tmax 1.98 h, and the half-life (t1/2) was 83.45 h. The 90% confidence intervals of ratios for Cmax, AUC0-t, and AUC0-∞ were within the range of 80.00%–125.00%. After infusion, one (2.0%) subject in the LZM008 group and three (6.4%) subjects in the ACTEMRA® group showed positive ADA test results. The incidence of treatment emergent adverse events (TEAEs) was comparable in LZM008 and ACTEMRA® groups (98.0% versus 100%), with the decrease in blood fibrinogen and neutrophil counts being the most common TEAEs.

Conclusion: The pharmacokinetic characteristics and immunogenicity exhibited by LZM008 were similar to those of the reference product, ACTEMRA®. The safety profiles of LZM008 were similar in the two groups with mild–moderate adverse effects.

Trial Registration: The trial is registered at www.chinadrugtrials.org.cn (CTR20190889).
Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis
Authors: Zheng Fang , Wang Yeshu , Zhang Qunfang , Chen Qiuyuan , Liang Chun-Ling , Liu Huazhen , Qiu Feifei , Chen Yuchao , Huang Haiding , Lu Weihui , Dai Zhenhua
Published: April 2023

Background: Ferroptosis is a new form of regulated cell death characterized by the accumulation of iron-dependent lipid peroxides and membrane damages. Recent studies have identified an important role for cancer cell ferroptosis in antitumor therapy. On the other hand, polyphyllin I (PPI) has been reported to exert antitumor effects on some types of cancers. However, it remains unknown whether or not PPI regulates cancer cell ferroptosis.

Methods: Two types of human gastric cancer cells (AGS and MKN-45) were used to establish tumor xenograft models in nude mice that were treated with polyphyllin I (PPI) to observe tumor growth, while cells also were cultured for in vitro studies. Ferroptosis, based on the intracellular ROS/lipid ROS production and accumulation of ferrous ions, was detected using a fluorescence microscope and flow cytometer, while the expression of NRF2/FTH1 was measured using Western blotting assays.

Results: Here we found that PPI inhibited the gastric cancer growth in vivo and in vitro while increasing the intracellular reactive oxygen species (ROS)/lipid peroxides and ferrous ions in the gastric cancer cells. PPI also decreased the levels of nuclear factor erythroid 2-related factor 2 (NRF2) and ferritin heavy chain 1 (FTH1) in gastric cancer cells in vitro. Moreover, liproxstain-1, an inhibitor of cell ferroptosis, mostly reversed the cell ferroptosis and tumor growth arrest induced by PPI. Finally, the effects of PPI on cancer cell ferroptosis were diminished by the overexpression of NRF2.

Conclusion: For the first time, our results have demonstrated that PPI exerts its antitumor activity on the gastric cancer by, at least partially, inducing cancer cell ferroptosis via regulating NRF2/FTH1 pathway. These findings may be implicated for clinical replacement therapy of the gastric cancer.