bluuebunny/crossref_metadata_2025 huggingface dataset:
Differences in Brain Atrophy Pattern between People with Multiple Sclerosis and Systemic Diseases with Central Nervous System Involvement Based on Two-Dimensional Linear Measures
Authors: Siger Małgorzata , Wydra Jacek , Wildner Paula , Podyma Marek , Puzio Tomasz , Matera Katarzyna , Stasiołek Mariusz , Świderek-Matysiak Mariola
Published: January 2024

Conventional brain magnetic resonance imaging (MRI) in systemic diseases with central nervous system involvement (SDCNS) may imitate MRI findings of multiple sclerosis (MS). In order to better describe the MRI characteristics of these conditions, in our study we assessed brain volume parameters in MS (n = 58) and SDCNS (n = 41) patients using two-dimensional linear measurements (2DLMs): bicaudate ratio (BCR), corpus callosum index (CCI) and width of third ventricle (W3V). In SDCNS patients, all 2DLMs were affected by age (CCI p = 0.005, BCR p < 0.001, W3V p < 0.001, respectively), whereas in MS patients only BCR and W3V were (p = 0.001 and p = 0.015, respectively). Contrary to SDCNS, in the MS cohort BCR and W3V were associated with T1 lesion volume (T1LV) (p = 0.020, p = 0.009, respectively) and T2 lesion volume (T2LV) (p = 0.015, p = 0.009, respectively). CCI was associated with T1LV in the MS cohort only (p = 0.015). Moreover, BCR was significantly higher in the SDCNS group (p = 0.01) and CCI was significantly lower in MS patients (p = 0.01). The best predictive model to distinguish MS and SDCNS encompassed gender, BCR and T2LV as the explanatory variables (sensitivity 0.91; specificity 0.68; AUC 0.86). Implementation of 2DLMs in the brain MRI analysis of MS and SDCNS patients allowed for the identification of diverse patterns of local brain atrophy in these clinical conditions.
Radiomic Analysis in Pituitary Tumors: Current Knowledge and Future Perspectives
Authors: Bioletto Fabio , Prencipe Nunzia , Berton Alessandro Maria , Aversa Luigi Simone , Cuboni Daniela , Varaldo Emanuele , Gasco Valentina , Ghigo Ezio , Grottoli Silvia
Published: January 2024

Radiomic analysis has emerged as a valuable tool for extracting quantitative features from medical imaging data, providing in-depth insights into various contexts and diseases. By employing methods derived from advanced computational techniques, radiomics quantifies textural information through the evaluation of the spatial distribution of signal intensities and inter-voxel relationships. In recent years, these techniques have gained considerable attention also in the field of pituitary tumors, with promising results. Indeed, the extraction of radiomic features from pituitary magnetic resonance imaging (MRI) images has been shown to provide useful information on various relevant aspects of these diseases. Some of the key topics that have been explored in the existing literature include the association of radiomic parameters with histopathological and clinical data and their correlation with tumor invasiveness and aggressive behavior. Their prognostic value has also been evaluated, assessing their role in the prediction of post-surgical recurrence, response to medical treatments, and long-term outcomes. This review provides a comprehensive overview of the current knowledge and application of radiomics in pituitary tumors. It also examines the current limitations and future directions of radiomic analysis, highlighting the major challenges that need to be addressed before a consistent integration of these techniques into routine clinical practice.
Retrospective Analysis of Ultrasound-Guided Serial-Injection Triple Nerve Block Efficacy in Cementless Bipolar Hemiarthroplasty for Femoral Neck Fracture
Authors: Huh Jung Wook , Kim Min Woo , Noh Young Min , Seo Han Eol , Lee Dong Ha
Published: January 2024

Background: Femoral neck fractures are effectively treated with bipolar hemiarthroplasty (BHA) surgery, yet postoperative pain management remains a challenge. This study explores the efficacy of multimodal pain management in minimizing opioid use and enhancing recovery. Methods: A retrospective analysis of 87 patients who underwent BHA between September 2016 and September 2020 was conducted. Patients were analyzed in two groups: Group I (n = 42), receiving serial-injection nerve blocks (SINBs) before and after surgery, and Group II (n = 41), with no SINB. Notably, all nerve blocks for Group I were performed after November 2017, following the implementation of this technique in our protocol. Pain and analgesic medication usage were assessed over 72 h post-surgery, along with hospitalization duration and perioperative complications. Results: Group I patients exhibited significantly lower pain scores at 6, 12, 24, and 48 h post-surgery, alongside reduced incidences of postoperative nausea and vomiting (PONV) and delirium compared with Group II (p < 0.05). Conclusions: Utilizing sequential lower limb nerve blocks under ultrasound guidance in BHA surgeries effectively reduces early postoperative pain and associated adverse effects. This approach demonstrates potential benefits in pain management, leading to diminished narcotic usage and lower risks of PONV and delirium.
Assessment of Children and “Young” Adult Patients’ Quality of Life after Prosthetic Treatment of Disorders of the Craniofacial Region—A Retrospective Study
Authors: Wojtyńska Elżbieta , Bączkowski Bohdan , Cierech Mariusz , Mierzwińska-Nastalska Elżbieta
Published: January 2024

Background: Prosthetic rehabilitation for children and juvenile patients with congenital or acquired craniofacial disorders is the area of activity of many clinicians and is a major diagnostic and therapeutic challenge for dentists. Methods: Studies were carried out on a group of 30 patients (10 female and 20 male) aged 2.5 to 30 years who were treated prosthetically due to congenital and acquired craniofacial disorders. The aim of this study was to assess the quality of life using the CPQ 11-14 (Child Perception Questionnaire 11-14), OQLQ (Orthognathic Quality of Life Questionnaire), and PIDAQ (Psychosocial Impact of Dental Aesthetics Questionnaire). Results: Before the prosthetic treatments, the mean values in the individual questionnaires were, respectively, CPQ 11-14—54 points; OQLQ—44.4 points; and PIDAQ—47.6 points. The following values were obtained after the treatments: CPQ 11-14—12.43 points; OQLQ—22.27 points; and PIDAQ—34.03 points. All obtained differences were statistically significant. Conclusions: The total numerical results obtained in all questionnaires decreased, which means that prosthetic rehabilitation had a positive impact on the assessment of the quality of life based on individual categories.
Infectious Complications of Pulmonary Sarcoidosis
Authors: Valeyre Dominique , Bernaudin Jean-François , Brauner Michel , Nunes Hilario , Jeny Florence
Published: January 2024

In this review, the infectious complications observed in sarcoidosis are considered from a practical point of view to help the clinician not to overlook them in a difficult context, as pulmonary sarcoidosis makes the recognition of superinfections more difficult. An increased incidence of community-acquired pneumonia and of opportunistic pneumonia has been reported, especially in immunosuppressed patients. Pulmonary destructive lesions of advanced sarcoidosis increase the incidence of chronic pulmonary aspergillosis and infection by other agents. Screening and treatment of latent tuberculosis infection are crucial to prevent severe tuberculosis. Severity in COVID-19 appears to be increased by comorbidities rather than by sarcoidosis per se. The diagnosis of infectious complications can be challenging and should be considered as a potential differential diagnosis when the exacerbation of sarcoidosis is suspected. These complications not only increase the need for hospitalizations, but also increase the risk of death. This aspect must be carefully considered when assessing the overall health burden associated with sarcoidosis. The impact of immune dysregulation on infectious risk is unclear except in exceptional cases. In the absence of evidence-based studies on immunosuppressants in the specific context of pulmonary sarcoidosis, it is recommended to apply guidelines used in areas outside sarcoidosis. Preventive measures are essential, beginning with an appropriate use of immunosuppressants and the avoidance of unjustified treatments and doses. This approach should take into account the risk of tuberculosis, especially in highly endemic countries. Additionally, parallel emphasis should be placed on vaccinations, especially against COVID-19.
AI in Orthodontics: Revolutionizing Diagnostics and Treatment Planning—A Comprehensive Review
Authors: Kazimierczak Natalia , Kazimierczak Wojciech , Serafin Zbigniew , Nowicki Paweł , Nożewski Jakub , Janiszewska-Olszowska Joanna
Published: January 2024

The advent of artificial intelligence (AI) in medicine has transformed various medical specialties, including orthodontics. AI has shown promising results in enhancing the accuracy of diagnoses, treatment planning, and predicting treatment outcomes. Its usage in orthodontic practices worldwide has increased with the availability of various AI applications and tools. This review explores the principles of AI, its applications in orthodontics, and its implementation in clinical practice. A comprehensive literature review was conducted, focusing on AI applications in dental diagnostics, cephalometric evaluation, skeletal age determination, temporomandibular joint (TMJ) evaluation, decision making, and patient telemonitoring. Due to study heterogeneity, no meta-analysis was possible. AI has demonstrated high efficacy in all these areas, but variations in performance and the need for manual supervision suggest caution in clinical settings. The complexity and unpredictability of AI algorithms call for cautious implementation and regular manual validation. Continuous AI learning, proper governance, and addressing privacy and ethical concerns are crucial for successful integration into orthodontic practice.
Advances and Applications of Lung Organoids in the Research on Acute Respiratory Distress Syndrome (ARDS)
Authors: Zhang Xingwu , Su Longxiang , Pan Pan
Published: January 2024

Acute Respiratory Distress Syndrome (ARDS) is a sudden onset of lung injury characterized by bilateral pulmonary edema, diffuse inflammation, hypoxemia, and a low P/F ratio. Epithelial injury and endothelial injury are notable in the development of ARDS, which is more severe under mechanical stress. This review explains the role of alveolar epithelial cells and endothelial cells under physiological and pathological conditions during the progression of ARDS. Mechanical injury not only causes ARDS but is also a side effect of ventilator-supporting treatment, which is difficult to model both in vitro and in vivo. The development of lung organoids has seen rapid progress in recent years, with numerous promising achievements made. Multiple types of cells and construction strategies are emerging in the lung organoid culture system. Additionally, the lung-on-a-chip system presents a new idea for simulating lung diseases. This review summarizes the basic features and critical problems in the research on ARDS, as well as the progress in lung organoids, particularly in the rapidly developing microfluidic system-based organoids. Overall, this review provides valuable insights into the three major factors that promote the progression of ARDS and how advances in lung organoid technology can be used to further understand ARDS.
Impact of Cough Severity on the Diagnostic Yield of Endobronchial Ultrasonography Transbronchial Biopsy with Guide Sheath: A Retrospective Observational Study
Authors: Kobayashi Fumi , Saraya Takeshi , Akizawa Takatora , Abe Taro , Takagi Ryo , Ieki Eriko , Ishikawa Narishige , Kurokawa Nozomi , Aso Jumpei , Nunokawa Hiroki , Nakamoto Yasuo , Ishida Manabu , Sada Mitsuru , Nakamoto Keitaro , Takata Saori , Ishii Haruyuki
Published: January 2024

Bronchoscopy is an invasive procedure, and patient coughing during examination has been reported to cause patient distress. This study aimed to clarify the relationship between cough severity and diagnostic yield of endobronchial ultrasonography with guide sheath transbronchial biopsy (EBUS-GS-TBB). Data of patients who underwent bronchoscopy at Kyorin University Hospital between April 2019 and March 2022 were retrospectively evaluated. Bronchoscopists assessed the cough severity upon completion of the procedure using a four-point cough scale. Cough severity was included as a predictive factor along with those reportedly involved in bronchoscopic diagnosis, and their impact on diagnostic yield was evaluated. Predictors of cough severity were also examined. A total of 275 patients were enrolled in this study. In the multivariate analysis, the diagnostic group (n = 213) had significantly more ‘within’ radial endobronchial ultrasound findings (odds ratio [OR] 5.900, p < 0.001), a lower cough score (cough score per point; OR 0.455, p < 0.001), and fewer bronchial generations to target lesion(s) (OR 0.686, p < 0.001) than the non-diagnostic group (n = 62). The predictive factors for severe cough include the absence of virtual bronchoscopic navigation (VBN) and prolonged examination time. Decreased cough severity was a positive predictive factor for successful EBUS-GS-TBB, which may be controlled using VBN and awareness of the procedural duration.
Low-Pressure Plasma-Processed NiCo Metal–Organic Framework for Oxygen Evolution Reaction and Its Application in Alkaline Water Electrolysis Module
Authors: Su Yu-Lun , Yu Shuo-En , Ni I-Chih , Wu Chih-I , Chen Yong-Song , Chuang Yi-Cheng , Cheng I-Chun , Chen Jian-Zhang
Published: January 2024

Ar, Ar/H2 (95:5), and Ar/O2 (95:5) plasmas are used for treating the NiCo metal–organic framework (MOF), and the plasma-processed NiCo MOF is applied for catalyzing the oxygen evolution reaction (OER) in a 1 M KOH electrolyte. Linear sweep voltammetry measurements show that after plasma treatment with Ar/H2 (95:5) and Ar gases, the overpotential reaches 552 and 540 mV, respectively, at a current density of 100 mA/cm2. The increase in the double-layer capacitance further confirms the enhanced oxygen production activity. We test the Ar plasma-treated NiCo MOF as an electrocatalyst at the OER electrode and Ru as an electrocatalyst at the hydrogen evolution reaction (HER) electrode in the alkaline water electrolysis module. The energy efficiency of the electrolyzer with the Ar plasma-processed NiCo-MOF catalyst increases from 54.7% to 62.5% at a current density of 500 mA/cm2 at 25 °C. The alkaline water electrolysis module with the Ar plasma-processed catalyst also exhibits a specific energy consumption of 5.20 kWh/m3 and 4.69 kWh/m3 at 25 °C and 70 °C, respectively. The alkaline water electrolysis module performance parameters such as the hydrogen production rate, specific energy consumption, and energy efficiency are characterized at temperatures between 25 °C and 70 °C. Our experimental results show that the NiCo MOF is an efficient OER electrocatalyst for the alkaline water electrolysis module.
The Critical Photographic Variables Contributing to Skull-Face Superimposition Methods to Assist Forensic Identification of Skeletons: A Review
Authors: Healy Sean S. , Stephan Carl N.
Published: January 2024

When an unidentified skeleton is discovered, a video superimposition (VS) of the skull and a facial photograph may be undertaken to assist identification. In the first instance, the method is fundamentally a photographic one, requiring the overlay of two 2D photographic images at transparency for comparison. Presently, mathematical and anatomical techniques used to compare skull/face anatomy dominate superimposition discussions, however, little attention has been paid to the equally fundamental photographic prerequisites that underpin these methods. This predisposes error, as the optical parameters of the two comparison photographs are (presently) rarely matched prior to, or for, comparison. In this paper, we: (1) review the basic but critical photographic prerequisites that apply to VS; (2) propose a replacement for the current anatomy-centric searches for the correct ‘skull pose’ with a photographic-centric camera vantage point search; and (3) demarcate superimposition as a clear two-stage phased procedure that depends first on photographic parameter matching, as a prerequisite to undertaking any anatomical comparison(s).
The Non-Singular Terminal Sliding Mode Control of Underactuated Unmanned Surface Vessels Using Biologically Inspired Neural Network
Authors: Xu Donghao , Li Zelin , Xin Ping , Zhou Xueqian
Published: January 2024

Underactuated Unmanned Surface Vessels (USVs) are widely used in civil and military fields due to their small size and high flexibility, and trajectory tracking control is a critical research area for underactuated USVs. This paper proposes a trajectory tracking control strategy using the Biologically Inspired Neural Network (BINN) for USVs to improve tracking speed and accuracy. A virtual control law is designed to obtain the required virtual velocity for trajectory tracking control, in which the velocity error is calibrated to ensure that the position error converges to zero. To observe and compensate for unknown and complex environmental disturbances such as wind, waves, and currents, a nonlinear extended state observer (NESO) is designed. Then, a controller based on Non-singular Terminal Sliding Mode (NTSM) is designed to resolve the problems of singular value and controller chattering and to improve the controller response speed. A BINN is introduced to simplify the process of differentiation, reduce the input values of the initial state, and solve the problem of thruster input saturation. Finally, the Lyapunov stability theory is utilized to analyze the stability of the proposed algorithm. The simulation results show that the proposed algorithm has a higher trajectory tracking accuracy and speed than traditional methods.
Spatial Design Thinking in Coastal Defence Systems: Overtopping Dikes in Southend-On-Sea
Authors: Iuorio Luca , Wüthrich Davide , Teng Djimin , Hooimeijer Fransje
Published: January 2024

Coastal dikes have been built for millennia to protect inhabited lands from exceptional high tides and storm events. Currently, many European countries are developing specific programs to integrate the construction of new dikes (or the raising of existing ones) into the built environment to face sea level rising. Technical difficulties in succeeding in this operation are questioning the paradigm of protection for the long term, pointing out the need for alternative strategies of adaptation that are not yet fully explored. This paper elaborates on innovative models to deal with coastal flooding, presenting the results of an interdisciplinary research and design process for the case-study of Southend-on-Sea (UK). Detailed numerical simulations are used to develop a spatial strategy to accommodate water during extreme events, introducing different prototypes of dike designs that include seawalls, enhanced roughness through rock and stepped revetments, as well as vegetation. The overall goal is to push forward the traditional approach of planning water protection infrastructure within the solely field of civil engineering. It elaborates on the integration of the disciplines of spatial design and engineering and presents novel advances in terms of spatial design for the revetment of overtopping dikes.
Perceived Health Benefits in Vestibular Schwannoma Patients with Long-Term Postoperative Headache: Insights from Personality Traits and Pain Coping—A Cross-Sectional Study
Authors: Thomas Mareike , Führes Hannah , Scheer Maximilian , Rampp Stefan , Strauss Christian , Schönfeld Robby , Leplow Bernd
Published: January 2024

Postoperative headaches (POHs) following retrosigmoid microsurgery for vestibular schwannoma (VS) can significantly impact patients’ perceived health benefits (PHBs). In this cross-sectional observational study, 101 VS patients were investigated. For the assessment of pain, the Rostock Headache Compendium (RoKoKo) and the German pain processing questionnaire (FESV) were used. The perceived health benefits (PHBs) were assessed by the Glasgow Benefit Inventory (GBI) and Big Five personality traits were measured using the Ten-Item Personality Inventory (TIPI-G). We showed that 55% of the participants experienced POHs, leading to a marked reduction in overall PHBs compared to those without POHs. The correlation analysis revealed an association between decreased PHBs and elevated levels of pain-related helplessness, depression, anxiety, and anger. Positive correlations were identified between PHBs and action-planning competence, cognitive restructuring, and the experience of competence. Low emotional stability and openness yielded associations with pain-related psychological impairment. Hearing loss and facial paresis did not exert a significant impact on PHBs. The study highlights the influence of pain-related coping strategies on PHBs in long-term POH patients. Thus, coping mechanisms and personality traits should be assessed even before surgery for post-surgery pain prevention. The limitations of this study include a relatively small sample size, potential biases introduced by the overrepresentation of female patients, and the use of an online survey methodology. In conclusion, this research highlights that the interplay between headaches, PHBs, and psychological factors is also relevant in VS patients undergoing microsurgery. Short-term psychological interventions should therefore be taken into account to improve post-surgery adaptive coping strategies.
An Investigation into the Spatial Distribution of British Housing Market Activity
Authors: Gray David Paul
Published: January 2024

This paper sets out to consider how a simple and easy-to-estimate power-law exponent can be used by policymakers to assess changes in economic inequalities, where the data can have a long tail—common in analyses of economic disparities—yet does not necessarily deviate from log-normality. The paper finds that the time paths of the coefficient of variation and the exponents from Lavalette’s function convey similar inferences about inequalities when analysing the value of house purchases over the period 2001–2022 for England and Wales. The house price distribution ‘steepens’ in the central period, mostly covering the post-financial-crisis era. The distribution of districts’ expenditure on house purchases ‘steepens’ more quickly. This, in part, is related to the loose monetary policy associated with QE driving a wedge between London and the rest of the nation. As prices can rise whilst transactions decline, it may be better for policymakers to focus on the value of house purchases rather than house prices when seeking markers of changes in housing market activity.
Where Are the Trade-Offs in Multiple Ecosystem Services in the Process of Ecological Restoration? A Case Study on the Vegetation Restoration Area in the Loess Plateau, Northern Shaanxi
Authors: Wen Xin , Wang Jijun , Han Xiaojia , Ma Lihui
Published: January 2024

Revealing trade-off and synergistic relationships among ecosystem services plays a key role in ensuring a stable ecosystem for long-term development. It is the crucial precondition for realizing watershed protection and high-quality development. The variations in land use during 1990–2020 are investigated by taking the typical areas for returning farmland to forests as an example. The spatiotemporal distributions of six key ecosystem services, namely carbon storage, water yield, net primary productivity (NPP), soil conservation, habitat quality, and forest recreation are quantified by the InVEST model and statistical data. We also uncover the spatial difference in the ecosystem in Loess Plateau, located in northern Shaanxi, with hot spot analysis and probe the trade-off and synergistic correlations among the investigated ecosystem services. The results show that: (1) the farmland decreased dramatically. On the contrary, the forests and orchards increased significantly. (2) During the same period, carbon storage and habitat quality increased, and water yield, NPP, soil conservation, and forest recreation initially declined, but subsequently rose to higher values than that in 1990. All these services in the southeastern part of the research area surpass those found in the northwest. (3) The ecosystem services relationships in northern Shaanxi are mainly characterized by synergistic correlations, which became stronger from 1990 to 2020. The trade-off effects mainly occur among the water yield and other ecosystem services and are distributed in the west and north of the investigated area. Based on these findings, this work provides scientific principles for improving the ecological environment and enhancing the resource sustainability of the study area.
Paradoxical Psoriasis Induced by Ustekinumab: A Comprehensive Review and Case Report
Authors: Olteanu Andrei , Klimko Artsiom , Tieranu Ioana , Orzan Olguta , Toma Cristian , Ionescu Elena , Preda Carmen , Tieranu Cristian
Published: January 2024

Ustekinumab (UST), a biologic agent targeting interleukin-12 and interleukin-23, is widely used in the management of psoriasis and Crohn’s disease. Despite its efficacy, there have been instances of paradoxical psoriasis induction or exacerbation in some patients during UST therapy. This paper offers a comprehensive review of reported cases of UST-induced paradoxical psoriasis, including a case from our clinic. We focus on a 39-year-old female patient with a history of long-standing Crohn’s disease who developed a psoriasiform rash, as confirmed by biopsy, while undergoing UST treatment. The patient’s clinical journey, from initial diagnosis through the complexities of treatment adjustments due to various complications including drug-induced lupus and the subsequent onset of psoriatic manifestations, provides insight into the challenges encountered in the clinical management of such cases. This review emphasizes the necessity for clinicians to recognize the possibility of paradoxical psoriasis in patients receiving UST treatment and calls for further research to better understand this phenomenon and devise effective management strategies.
Differences in Health-Related Quality of Life among Patients with Heart Failure
Authors: Ventoulis Ioannis , Kamperidis Vasileios , Abraham Maria Roselle , Abraham Theodore , Boultadakis Antonios , Tsioukras Efthymios , Katsiana Aikaterini , Georgiou Konstantinos , Parissis John , Polyzogopoulou Effie
Published: January 2024

Heart failure (HF) is characterized by a progressive clinical course marked by frequent exacerbations and repeated hospitalizations, leading to considerably high morbidity and mortality rates. Patients with HF present with a constellation of bothersome symptoms, which range from physical to psychological and mental manifestations. With the transition to more advanced HF stages, symptoms become increasingly more debilitating, interfere with activities of daily living and disrupt multiple domains of life, including physical functioning, psychological status, emotional state, cognitive function, intimate relationships, lifestyle status, usual role activities, social contact and support. By inflicting profuse limitations in numerous aspects of life, HF exerts a profoundly negative impact on health-related quality of life (HRQOL). It is therefore not surprising that patients with HF display lower levels of HRQOL compared not only to the general healthy population but also to patients suffering from other chronic diseases. On top of this, poor HRQOL in patients with HF becomes an even greater concern considering that it has been associated with unfavorable long-term outcomes and poor prognosis. Nevertheless, HRQOL may differ significantly among patients with HF. Indeed, it has consistently been reported that women with HF display poorer HRQOL compared to men, while younger patients with HF tend to exhibit lower levels of HRQOL than their older counterparts. Moreover, patients presenting with higher New York Heart Association (NYHA) functional class (III–IV) have significantly more impaired HRQOL than those in a better NYHA class (I–II). Furthermore, most studies report worse levels of HRQOL in patients suffering from HF with preserved ejection fraction (HFpEF) compared to patients with HF with reduced ejection fraction (HFrEF) or HF with mildly reduced ejection fraction (HFmrEF). Last, but not least, differences in HRQOL have been noted depending on geographic location, with lower HRQOL levels having been recorded in Africa and Eastern Europe and higher in Western Europe in a recent large global study. Based on the observed disparities that have been invariably reported in the literature, this review article aims to provide insight into the underlying differences in HRQOL among patients with HF. Through an overview of currently existing evidence, fundamental differences in HRQOL among patients with HF are analyzed based on sex, age, NYHA functional class, ejection fraction and geographic location or ethnicity.
Sweat Rate, Sweat Sodium Losses, and Body Composition in Professional Male Soccer Players in Southwest Colombia
Authors: Suarez-Ortegón Milton Fabian , Zea-León Maria del Pilar , Astudillo-Gironza Angelica Maria , Garzón Silverio , Portela Gustavo Fabian , Villarreal-Nieto Oscar Daniel
Published: January 2024

Background and Objective: Dehydration and hyperhydration impact athletes’ performance. Exploring the fluid balance concerning body composition might help estimate individual hydration requirements. This area of research, particularly regarding sodium losses, has been relatively understudied. We evaluated the sweat rate (SR), sweat sodium losses, and their relationship with body composition in professional soccer players in Cali, Colombia. Materials and Methods: Thirty-two male players, aged 24.3 (±5.2) years, from the Colombian main soccer league, underwent high-intensity training at 32 °C (with a relative humidity of 79%). The outcome variables included SR, calculated using weight loss and fluid intake; forearm sweat sodium concentration (FSCC), measured through the direct ion-selective electrode method; and estimated the predicted whole sweat sodium loss (PWSSL) in mmol. Predictor variables (body mass, fat, and muscle masses) were estimated using the Deborah Kerr anthropometry method. The association between predictors and outcomes was assessed using linear regression. Results: The mean FSCC, PWSSL, and SR were 26.7 ± 11.3 mmol/L, 43 ± 15.9 mmol/L, and 1.7 ± 0.5 L/h, respectively. Body mass positively predicted FSCC in unadjusted and age/fat-mass-adjusted models [Beta 1.28, 95% confidence interval (CI) 0.39–2.18, p = 0.006], and continued related to FSCC after adjustment for muscle mass with marginal significance [Beta 0.85, 95% CI −0.02 to 1.73, p = 0.056]. Muscle mass was associated with the PWSSL in unadjusted and age/fat-mass-adjusted models [Beta 2.42, 95% CI 0.58–4.26, p = 0.012] and sustained an association with marginal statistical significance after adjustment for body mass [Beta 1.86, 95% CI −0.35 to 4.09, p = 0.097]. Conclusions: Under hot tropical weather conditions, FSCC was relatively low among the players. Body mass was better associated with the FSSC, and muscle mass better related to the PWSSL. Body and muscle masses could be regarded as potential factors to be explored in the estimation of individual sodium needs. However, further studies are required to validate and contrast our findings.
Predicting Neuroblastoma Patient Risk Groups, Outcomes, and Treatment Response Using Machine Learning Methods: A Review
Authors: Jahangiri Leila
Published: January 2024

Neuroblastoma, a paediatric malignancy with high rates of cancer-related morbidity and mortality, is of significant interest to the field of paediatric cancers. High-risk NB tumours are usually metastatic and result in survival rates of less than 50%. Machine learning approaches have been applied to various neuroblastoma patient data to retrieve relevant clinical and biological information and develop predictive models. Given this background, this study will catalogue and summarise the literature that has used machine learning and statistical methods to analyse data such as multi-omics, histological sections, and medical images to make clinical predictions. Furthermore, the question will be turned on its head, and the use of machine learning to accurately stratify NB patients by risk groups and to predict outcomes, including survival and treatment response, will be summarised. Overall, this study aims to catalogue and summarise the important work conducted to date on the subject of expression-based predictor models and machine learning in neuroblastoma for risk stratification and patient outcomes including survival, and treatment response which may assist and direct future diagnostic and therapeutic efforts.
Sigma Phase Stabilization by Nb Doping in a New High-Entropy Alloy in the FeCrMnNiCu System: A Study of Phase Prediction and Nanomechanical Response
Authors: Oñate Angelo , Sanhueza Juan Pablo , Dueña Gleydis , Wackerling Diego , Sauceda Sergio , Salvo Christopher , Valenzuela Marian , Medina Carlos , Seidou Abdul Herrim , Tchuindjang Jérôme Tchoufang , Meléndrez Manuel , Rojas David , Mertens Anne , Tuninetti Víctor
Published: January 2024

The development of high-entropy alloys has been hampered by the challenge of effectively and verifiably predicting phases using predictive methods for functional design. This study validates remarkable phase prediction capability in complex multicomponent alloys by microstructurally predicting two novel high-entropy alloys in the FCC + BCC and FCC + BCC + IM systems using a novel analytical method based on valence electron concentration (VEC). The results are compared with machine learning, CALPHAD, and experimental data. The key findings highlight the high predictive accuracy of the analytical method and its strong correlation with more intricate prediction methods such as random forest machine learning and CALPHAD. Furthermore, the experimental results validate the predictions with a range of techniques, including SEM-BSE, EDS, elemental mapping, XRD, microhardness, and nanohardness measurements. This study reveals that the addition of Nb enhances the formation of the sigma (σ) intermetallic phase, resulting in increased alloy strength, as demonstrated by microhardness and nanohardness measurements. Lastly, the overlapping VEC ranges in high-entropy alloys are identified as potential indicators of phase transitions at elevated temperatures.
Advanced Oxidative Protein Products Had a Diagnostic Accuracy for Identifying Chronic Kidney Disease in Adult Population
Authors: Villalpando-Sánchez Diana Carolina , Barajas-Medina César Arturo , Alvarez-Aguilar Cleto , López-Ortiz Geovani , Romero-Henríquez Luisa F. , Gómez-García Anel
Published: January 2024

Chronic Kidney Disease (CKD) is a serious public health problem. Hyperglycemia stimulates the production of reactive oxygen species that cause oxidative damage to proteins. AOPPs constitute a group of oxidized dityrosine-containing proteins that are generated during periods of oxidative stress. They have proved to be a valuable early marker of oxidative tissue damage and active mediators of inflammation associated with the uremic state. To analyze if advanced oxidative protein products (AOPPs) have diagnostic accuracy for identifying chronic kidney disease (CKD) in the adult population. We conducted a diagnostic test validation study in 302 adults ≥20 years old, of both sexes, with and without T2D. After obtaining informed consent, a comprehensive clinical history, anthropometric measurements (weight, BMI) and blood pressure were recorded. Glucose, cholesterol, triglyceride, HDL-c, LDL-c and AOPPs were determinates. Glomerular filtration rate (GFR) was calculated using Cockcroft–Gault (C–G) corrected by body surface area (BSA, mL/min/1.73 m2), CKD-EPI and MDRD equations to identify five stages of CKD. This study follows the Standards for Reporting Diagnostic Accuracy Studies (STARD). The median value of AOPPs was 198.32 µmol/L (minimum-maximum value: 113.48–522.42 µmol/L). The group with patients diagnosed with T2D exhibited higher concentrations (median: 487.39 µmol/L) compared to the non-diabetic group (median: 158.50 µmol/L, p = 0.0001). The selected cut-off point was ≥200 µmol/L using the closest to the median value of AOPPs with sensitivity and specificity as follows: C–G: sensitivity 96.58%; specificity 80%; likelihood ratio: 4.83; CKD-EPI: sensitivity 95.76%; specificity 79.89%; likelihood ratio: 4.76; MDRD: sensitivity 86.55%; specificity: 73.22%; likelihood ratio: 3.23. A difference was observed between AOPPs and chronic kidney disease stage. This study provides evidence that AOPPs ≥ 200 µmol/L have diagnostic accuracy in identifying stage 4–5 CKD by C–G, MDRD and CKD-EPI equations in adults with and without T2D.
Ultra-Bend-Resistant 4-Core Simplex Cable Used for Short-Reach Dense Spatial Division Multiplexing Optical Transmission
Authors: Zhang Zelin , Qin Yu , Zhu Jie , Wang Caoyuan , Jiang Xinli , Shen Yichun , Xiao Limin
Published: January 2024

We optimized and fabricated an ultra-bend-resistant 4-core simplex cable (SXC) employing 4-core multicore fiber (MCF) suitable for short-reach dense spatial division multiplexing (DSDM) optical transmission in the O-band. The characteristics of transmission loss, macro-bending and cross-talk (XT) between adjacent cores after cabling were firstly clarified. By introducing the trapezoid index and optimizing the cabling process, the maximum values of added XT of 1.17 dB/km due to 10 loops with a bending radius of 6 mm imposed over the 4-core SXC and a macro-bending loss of 0.37 dB/10 turns were, respectively, achieved.P Then, the optical transmission with low bit error rate (BER) was presented using a 100GBASE-LR4 transceiver over the 1.2 km long 4-core SXC. The excellent bending resistance of the 4-core SXC may pave the way for a reduction in space pressure and increase in access density on short-reach optical interconnect (OI) based on DSDM.
Synthesis and Structural and Optical Behavior of Dehydrohelicene-Containing Polycyclic Compounds
Authors: Khalid Md. , Salem Mohamed , Takizawa Shinobu
Published: January 2024

Dehydrohelicene-based molecules stand out as highly promising scaffolds and captivating chiroptical materials, characterized by their unique chirality. Their quasi-helical π-conjugated molecular architecture, featuring successively ortho-annulated aromatic rings, endows them with remarkable thermal stability and optical properties. Over the past decade, diverse approaches have emerged for synthesizing these scaffolds, reinvigorating this field, with anticipated increased attention in the coming years. This review provides a comprehensive overview of the historical evolution of dehydrohelicene chemistry since the pioneering work of Zander and Franke in 1969 and highlights recent advancements in the synthesis of various molecules incorporating dehydrohelicene motifs. We elucidate the intriguing structural features and optical merits of these molecules, occasionally drawing comparisons with their helicene or circulene analogs to underscore the significance of the bond between the helical termini.
An Investigation into the Stability Source of Collagen Fiber Modified Using Cr(III): An Adsorption Isotherm Study
Authors: Li Jiheng , Long Wenjun , Peng Liangqiong , Guo Lijun , Zhang Wenhua
Published: January 2024

The enhanced hydrothermal stability of leather, imparted by little Cr(III), has traditionally been ascribed to strong coordinate bonds. However, this explanation falls short when considering that the heat-induced shrinking of collagen fiber is predominantly driven by rupturing weak H-bonds. This study explored the stability source via adsorption thermodynamics using collagen fiber as an adsorbent. Eleven isotherm models were fitted with the equilibrium dataset. Nine of these models aptly described Cr(III) adsorption based on the physical interpretations of model parameters and error functions. The adsorption equilibrium constants from six models could be transformed into dimensionless thermodynamic equilibrium constants. Based on the higher R2 of the van’t Hoff equation, thermodynamic parameters (∆G°, ∆H°, ∆S°) from the Fritz–Shluender isotherm model revealed that the adsorption process typifies endothermic and spontaneous chemisorption, emphasizing entropy increase as the primary driver of Cr(III) bonding with collagen. Thus, the release of bound H2O from collagen is identified as the stability source of collagen fiber modified by Cr(III). This research not only clarifies the selection and applicability of the isotherm model in a specific aqueous system but also identifies entropy, rather than enthalpy, as the principal stability source of Cr-leather. These insights facilitate the development of novel methods to obtain stable collagen-based material.
New Trends in Biosurfactants: From Renewable Origin to Green Enhanced Oil Recovery Applications
Authors: Shaikhah Dilshad , Loise Valeria , Angelico Ruggero , Porto Michele , Calandra Pietro , Abe Abraham A. , Testa Flaviano , Bartucca Concetta , Oliviero Rossi Cesare , Caputo Paolino
Published: January 2024

Enhanced oil recovery (EOR) processes are technologies used in the oil and gas industry to maximize the extraction of residual oil from reservoirs after primary and secondary recovery methods have been carried out. The injection into the reservoir of surface-active substances capable of reducing the surface tension between oil and the rock surface should favor its extraction with significant economic repercussions. However, the most commonly used surfactants in EOR are derived from petroleum, and their use can have negative environmental impacts, such as toxicity and persistence in the environment. Biosurfactants on the other hand, are derived from renewable resources and are biodegradable, making them potentially more sustainable and environmentally friendly. The present review intends to offer an updated overview of the most significant results available in scientific literature on the potential application of biosurfactants in the context of EOR processes. Aspects such as production strategies, techniques for characterizing the mechanisms of action and the pros and cons of the application of biosurfactants as a principal method for EOR will be illustrated and discussed in detail. Optimized concepts such as the HLD in biosurfactant choice and design for EOR are also discussed. The scientific findings that are illustrated and reviewed in this paper show why general emphasis needs to be placed on the development and adoption of biosurfactants in EOR as a substantial contribution to a more sustainable and environmentally friendly oil and gas industry.
A Rare Benzothiazole Glucoside as a Derivative of ‘Albedo Bluing’ Substance in Citrus Fruit and Its Antioxidant Activity
Authors: Yang Chao , Yu Chuanxiu , Li Qiang , Peng Liangzhi , Chun Changpin , Tang Xiaolong , Liu Song , Hu Chengbo , Ling Lili
Published: January 2024

‘Albedo bluing’ of fruits occurs in many varieties of citrus, resulting in a significant reduction in their commercial value. We first presented a breakthrough method for successfully extracting and purifying the ‘albedo bluing’ substance (ABS) from citrus fruits, resulting in the attainment of highly purified ABS. Then, HPLC and UPLC-QTOF-MS were used to prove that ABS in the fruits of three citrus varieties (Citrus reticulate Blanco cv. ‘Gonggan’, ‘Orah’, and ‘Mashuiju’) are identical. However, the chemical structure of ABS remains elusive for many reasons. Fortunately, a more stable derivative of ABS (ABS-D) was successfully obtained. Through various analytical techniques such as HRESIMS, 1D and 2D NMR, and chemical shift calculation, ABS-D was identified as 2,4-dihydroxy-6-(β-D-glucopyranosyloxy)phenyl(5,6-dihydroxy-7-(β-D-glucopyranosyloxy)benzo[d]thiazol-2-yl)methanone, indicating that both ABS and its derivative belong to a rare category of benzothiazole glucosides. Furthermore, both ABS and ABS-D demonstrated potent antioxidant abilities. These findings lay the groundwork for further elucidating the chemical structure of ABS and the causative mechanism of the ‘albedo bluing’ phenomenon in citrus fruits.
DFT Exploration of Metal Ion–Ligand Binding: Toward Rational Design of Chelating Agent in Semiconductor Manufacturing
Authors: Wang Wenyuan , Zhu Junli , Huang Qi , Zhu Lei , Wang Ding , Li Weimin , Yu Wenjie
Published: January 2024

Chelating agents are commonly employed in microelectronic processes to prevent metal ion contamination. The ligand fragments of a chelating agent largely determine its binding strength to metal ions. Identification of ligands with suitable characteristics will facilitate the design of chelating agents to enhance the capture and removal of metal ions from the substrate in microelectronic processes. This study employed quantum chemical calculations to simulate the binding process between eleven ligands and the hydrated forms of Ni2+, Cu2+, Al3+, and Fe3+ ions. The binding strength between the metal ions and ligands was quantified using binding energy and binding enthalpy. Additionally, we explored the binding interaction mechanisms and explained the differences in binding abilities of the eleven ligands using frontier molecular orbitals, nucleophilic indexes, electrostatic potentials, and energy decomposition calculations based on molecular force fields. Based on our computational results, promising chelating agent structures are proposed, aiming to guide the design of new chelating agents to address metal ion contamination issues in integrated circuit processes.
In Situ Growth of Sodium Manganese Hexacyanoferrate on Carbon Nanotubes for High-Performance Sodium-Ion Batteries
Authors: Guo Can , Xing Jianxiong , Shamshad Ali , Jiang Jicheng , Wang Donghuang , Wang Xin , Bai Yixuan , Chen Haifeng , Sun Wenwu , An Naying , Zhou Aijun
Published: January 2024

Sodium manganese hexacyanoferrate (NaMnHCF) has emerged as a research hotspot among Prussian blue analogs for sodium-ion battery cathode materials due to its advantages of high voltage, high specific capacity, and abundant raw materials. However, its practical application is limited by its poor electronic conductivity. In this study, we aim to solve this problem through the in situ growth of NaMnHCF on carbon nanotubes (CNTs) using a simple coprecipitation method. The results show that the overall electronic conductivity of NaMnHCF is significantly improved after the introduction of CNTs. The NaMnHCF@10%CNT sample presents a specific capacity of 90 mA h g−1, even at a current density of 20 C (2400 mA g−1). The study shows that the optimized composite exhibits a superior electrochemical performance at different mass loadings (from low to high), which is attributed to the enhanced electron transport and shortened electron pathway. Surprisingly, the cycling performance of the composites was also improved, resulting from decreased polarization and the subsequent reduction in the side reactions at the cathode/electrolyte interface. Furthermore, we revealed the evolution of potential plateau roots from the extraction of crystal water during the charge–discharge process of NaMnHCF based on the experimental results. This study is instructive not only for the practical application of NaMnHCF materials but also for advancing our scientific understanding of the behavior of crystal water during the charge–discharge process.