bluuebunny/crossref_metadata_2025 huggingface dataset:
Jujol y el collage. Fragmentos de la finca Sansalvador
Authors: De Gispert Hernández Jordi
Published: March 2024

La descripción de la obra de Josep Maria Jujol ha suscitado diversidad de opiniones, sin embargo, hay un término que aparece repetidamente por parte de los expertos, el collage. Este escrito comprueba la pertinencia de aplicar dicho concepto a su obra, y especialmente a la finca Sansalvador. Primero se expone brevemente el uso del término collage para referirse a Jujol, así como una contextualización histórico-artística. De ésta se deduce que el collage puede entenderse de tres maneras: como recurso gráfico, como estrategia intelectual y como proceso. Luego se analiza el caso de estudio a través de estas tres acepciones, lo que permite descubrir la aparición de fragmentos descontextualizados de distintos orígenes, dispuestos de tal modo que generan imágenes aparentemente unitarias. Por consiguiente, la finca Sansalvador presenta el procedimiento de representación e intelectual que corresponde, punto por punto, a la definición de collage.
Medio siglo del edificio Sevilla 1: dibujo, geometría y prefabricación en la arquitectura moderna de OTAISA
Authors: Miró Miró Cristóbal , Pozo Bernal Melina , Mayoral Campa Esther
Published: March 2024

En 1968 se proyecta en Sevilla un modelo de edificio concebido por una oficina técnica pionera en la ciudad: OTAISA. De marcado carácter anglosajón, el edificio de oficinas modulares Sevilla 1, se convertirá en un referente de la arquitectura local. Su construcción, coherente con el carácter innovador de su programa, utilizó un sistema de prefabricación de fachada que no sólo resolvió un problema técnico, sino que representó la imagen icónica del primer edificio de oficinas modulares de la ciudad.
Esta investigación profundiza en el papel que los procesos gráficos de naturaleza geométrica tuvieron sobre el diseño de los módulos prefabricados de su envolvente, demostrándose la importancia del dibujo y la geometría en su ideación y desarrollo, y revindicando su importancia en el trazado regulador del edificio. Se ha completado la definición gráfica del proyecto original, aportando un material que este trabajo, a modo de investigación, pretende recrear.
Una reflexión teórica desde el dibujo de Rafael Moneo
Authors: Martín-Fuentes Daniel , Pérez de los Cobos Cassinello Marta , Molina Siles Pedro
Published: March 2024

En una pretendida aproximación histórica al dibujo de Arquitectura en España en el siglo XX, es sin duda obligatoria la presencia de una de las figuras nacionales más importantes de la disciplina y proyectista español vivo más premiado: Rafael Moneo Vallés. Por otro lado, es complicado abordar este tema que ya ha sido tratado por autores relevantes y en la que el propio arquitecto ha dedicado tiempo en sus entrevistas, foco en sus exposiciones y reflexiones en sus libros.
Haremos un repaso por los asuntos importantes que alrededor del dibujo se han sucedido en la vida del arquitecto, contrastaremos sus opiniones escritas y expresadas con alguna de su producción gráfica más relevante y extraeremos conclusiones que permitan aportar una lectura transversal sobre el dibujo, al que Moneo concede una extraordinaria importancia como ya puso negro sobre blanco Franco Taboada en esta misma revista a propósito de una exposición retrospectiva de la obra de Moneo (Franco Taboada, 2014).
Modernist Relations France-England: Le Corbusier, Clive Entwistle and exhibition projects
Authors: Luce Bohrer Mônica
Published: March 2024

In the context of the Modern Movement and influenced by Le Corbusier's design principles, this text explores the significance of the Swiss master's exhibition pavilion and fair projects. These projects, distinct from conventional architectural timelines, serve as evidence of the ideas shaping the project process, reflecting a compression of time and manifestos in physical form. Focusing on collaborations with English architect Clive Entwistle for exhibitions in England, particularly the 1939 Ideal Home Exhibition, the article delves into Le Corbusier's innovative designs, including a Ville Radieuse housing unit, a prefabricated house, and a luxury house. The text highlights Le Corbusier's strategic use of exhibition architecture as a platform to communicate his principles and theories, showcasing his work as a "laboratory" of projects. The article emphasizes the intertextuality of Le Corbusier's work, where ideas transcend projects, contexts, and meanings, fostering a dynamic relationship between theoretical reflections and practical experiences in pavilion and exhibition designs.
Between "Silhouette d'une ville" and "Patriotisme": Analyzing those Conceptions in “La Construction des Villes” through the Lens of Georges de Montenach’s “Pour le visage aimé de la patrie"
Authors: Hayakawa Sayuri , Taji Takahiro
Published: March 2024

This paper delves into Charles-Édouard Jeanneret’s inaugural urban study La Construction des Villes, exploring his pursuit of fostering citizens’ ‘local patriotism’. While Jeanneret, also known as young Le Corbusier, emphasises the importance of physical urban forms in generating this sentiment, the specific mechanism behind the emergence of local patriotism remains unclear in the manuscript. Our objective is to clarify the uniqueness and historical context of Jeanneret’s thoughts on local patriotism by examining its ideological background, particularly the foundation for creating this sentiment. The key concept, the ‘silhouette of a city’, borrowed from Georges de Montenach, lacks specific examples or forms in Jeanneret’s work. Jeanneret argues that visual clarity and its beauty form the basis for local patriotism. This abstraction, excluding the specificity of the place and translating symbolism into visual clarity, foreshadows Le Corbusier’s later modernist ideas. Unlike previous interpretations of inhabitants’ visual experiences, aligned with pre-modern German-speaking spatial theory, Jeanneret’s description of the silhouette of a city externalises the viewing subject, applying a limited scope of the landscape aligning with contemporary French-speaking discussions. The resulting collective consciousness, shared by external observers perceiving a clear silhouette of a city, is conceptualized as local patriotism.
Recensión tesis doctoral: "El otro urbanismo de Le Corbusier. Una mirada atenta a su legado urbanístico"
Authors: Martí Ciriquián Pablo
Published: March 2024

Recensión tesis doctoral:
Juan Andrés Rodríguez LoraEl otro urbanismo de Le Corbusier. Unamirada atenta a su legado urbanísticoDirectores: María Teresa Pérez Cano - Daniel Navas Carrillo - Marta SequeiraEscuela Técnica Superior de Arquitectura de la Universidad de Sevilla22 de septiembre de 2023
Tim Benton. The Painter Le Corbusier: Eileen Gray's Villa E 1027 and Le Cabanon
Authors: Torres Cueco Jorge
Published: March 2024

Coincidiendo con el cincuenta aniversario del fallecimiento de Le Corbusier, Tim Benton escribió Le Corbusier, peintre à Cap-Martin (Éditions du Patrimonie, 2015), que fue objeto de una reedición seis años después, también en francés. Sobre esta villa también ha publicado Cap Moderne. Eileen Gray and Le Corbusier. Modernisme by the Sea (2022) y ha colaborado en la antología E1027. Restoring a House by the Sea (2022). Con esta nueva versión inglesa viene a completar la difusión de este valioso libro que incide en una reconsideración crítica de la figura de Le Corbusier.
Cité Frugès. Tiempo en imágenes, imágenes en el tiempo
Authors: Bergera Iñaki
Published: March 2024

El presente texto acompaña al ensayo fotográfico sobre la Cité de Frugès, un barrio de Pessac próximo a Burdeos, proyectado por Le Corbusier y Pierre Jeanaret en 1924. La presentación de estas fotografías contemporáneas justifica por un lado un repaso —al cumplirse el centenario— a la controvertida historia de este proyecto iniciático de la trayectoria del arquitecto que le permitió poner en práctica a gran escala sus ideas sobre estandarización, industrialización y tipificación de la vivienda asequible y su interrelación con el espacio urbano. Por otra parte, ya en términos fotográficos, establece una lectura comparada con las fotografías del momento de su construcción y la intencional que estas tenían bajo el prisma operativo y discursivo de Le Corbusier. Y, por último, apunta al valor que la fotografía contemporánea tiene, como categorización estética, para redefinir la interpretación de lo real desde las coordenadas espacio temporales.
A Gestão da Diversidade em um ambiente de inovação
Authors: Freitas Tainá Araújo , Rodrigues Maria Beatriz
Published: March 2024

Objetivo. O artigo trata das relações entre gestão da diversidade e da inovação, em uma empresa de Tecnologia da Informação alocada em um Parque Científico e Tecnológico. Busca entender as influências da gestão da diversidade na inovação percebida na organização.
Métodos. A abordagem é qualitativa e realizada por meio de um estudo de caso. Foram considerados dados decorrentes da percepção dos trabalhadores entrevistados e informações adicionais, provenientes do Parque Científico e Tecnológico, onde a empresa está alocada.
Resultados. As políticas e práticas de gestão da diversidade da organização são coincidentes com a estratégia Integração e Aprendizagem, conforme Podsiadlowski et al. (2013). As relações entre diversidade e inovação foram reputadas como promotoras de resultados satisfatórios em engajamento e produtividade, além de impactarem em produtos, serviços e processos.
Conclusões. Os desafios enfrentados pela organização para desenvolver a gestão da diversidade foram significativos, tais como a promoção e manutenção de um ambiente seguro aos grupos minorizados, e a necessidade de trabalhar sobre formação e experiência dos mesmos.
O Odor do Café e a (In)Congruência da Atmosfera de Loja
Authors: Lira Jordana Soares de , Costa Marconi Freitas da , Silva Marianny Brito
Published: March 2024

Esse estudo buscou investigar a relação entre o odor do café em atmosferas (in)congruentes de loja e a intenção de recomendação do ambiente pelo consumidor. Para tanto, foi realizada uma pesquisa de natureza quantitativa e de caráter causal, com desenho experimental fatorial (2x2), com designs de grupos independentes (between subject), por meio de um estudo experimental em laboratório, com 201 participantes divididos aleatoriamente em quatro cenários de manipulação. Constatou-se que a simples associação do ambiente com o café trouxe respostas positivas dos consumidores em relação à atmosfera de loja. Assim, quando a atmosfera de loja é congruente com o cheiro do café, indivíduos possuem maior intenção em recomendá-la, independentemente da existência do odor do café no ambiente. No entanto, se a atmosfera é incongruente com tal cheiro, ainda que o odor do café esteja presente, as intenções de recomendação serão menores. A originalidade dessa pesquisa se dá na identificação de que, uma vez que a atmosfera de loja seja congruente com o cheiro do café, indivíduos terão maior intenção em recomendá-la, independentemente da existência do odor no ambiente. Tal achado é inédito, contribuindo para a reflexão no campo de estudo sobre congruência e odor na atmosfera de loja. Deste modo, fornecemos evidências que são úteis no design de atmosfera de lojas de varejo, reforçando a importância de obter um ambiente congruente com as percepções do consumidor sobre ele.
Estudos Baseados em Práticas como uma Alternativa Teórico-Metodológica para o Estudo de Novas Formas Organizacionais
Authors: Junges Vanessa de Campos , Campos Simone Alves Pacheco de , Becker Rúbia Goi , Marchi Janaina
Published: March 2024

Este estudo propõe o uso da lente teórico-metodológica das práticas como uma maneira (alternativa) de aprofundar e explorar as compreensões sobre os processos de aprendizagem em Novas Formas Organizacionais (NFO). A lente da prática amplia o entendimento da aprendizagem em NFO através de um olhar processual e relacional, explorado neste ensaio a partir da perspectiva de Gherardi, Nicolini, Strati e Latour. Trata-se de entender o conhecimento como um constante acontecendo, onde o saber éinerente à ação e, portanto, temporário, produzido, reproduzido e transformado a cada prática. A prática oferece uma alternativa ontoepistemológica que permite explorar o saber-fazer na tecitura de práticas produzidas pelos atores, fruto do nexo de relações e ações em fluxo. O uso da prática para compreender a aprendizagem em formas organizacionais que fogem do mainstream dos negócios, mostra-se possível através da compreensão de organização enquanto organizing, entendendo que estruturas surgem das relações, e como tal, e à medida que surge, também se desmantelam, trazendo assim a ideia de fluxo e ponto para dentro dos estudos organizacionais. Diferente das lentes teóricas marcadas pela ortodoxia sistêmica, a perspectiva da prática permite acessar nuances impulsionadoras dos processos de aprendizagem em coletivos constituídos pelas NFOs, deslocando o foco do ‘‘por quê’’ para o ‘‘como’’ as relações se agregam e produzem conhecimento. Os Estudos Baseados em Prática fornecem um olhar às subjetividades da vida organizacional, apoiando a gestão de NFO a partir do entendimento que a estrutura surge das relações e se molda pelas que nelas se estabelecem.
Directed Self-Placement for Multilingual, Multicultural International Students
Authors: Johnson Kristine , Vander Bie Sara
Published: March 2024

Directed self-placement (DSP) methods remain relatively rare in multilingual writing programs because such methods present unique ethical and academic risks. Grounded in five years of institutional research, this article reports on a first-year writing program in which DSP is the sole means of placement for international students and in which the international student population is linguistically, educationally, and culturally diverse. We offer logistical and technical guidance for creating DSP programs for multilingual writers, and we argue that DSP can be a vehicle for more equitable, socially just writing placement for multilingual, multicultural writers.
Manajemen transisi kurikulum 2013 menuju kurikulum merdeka di SD Negeri Pandeyan Yogyakarta
Authors: Resmiyati Resmiyati , Ringko Fitri Mela , Pramesti Rahmadhita , Zasilaturrohmah Dwi Evrilia , Tallo Maria Desti Bui , Alfriansyah Adhitya , Prasanti Arista Nida , Rachmadhani Nisakurin , Wahyuni Dini
Published: March 2024

Purpose − The aims of this research are (1) to describe the preparations of SD N Pandeyan in implementing the Independent Curriculum, (2) to describe the steps for implementing the 2013 Curriculum to the Independent Curriculum at SD N Pandeyan, (3) to describe the challenges and obstacles at SD N Pandeyan which has implemented Independent Curriculum. Method − This research is qualitative research with a case study approach, with interviews as a data collection technique. The data source in this research is the Principal of SD N Pandeyan. The data analysis technique uses an interactive data analysis technique which consists of data collection, data display, conclusion: drawing/verifying, and data condensation. Findings − The research results show that one of the preparations that needs to be done is training educators, especially class I and IV teachers. Meanwhile, the steps for implementing the Independent Curriculum are carried out by combining it with the previous curriculum, and the Independent Curriculum emphasizes character education, not just mastery of knowledge. In implementing the Independent Curriculum, of course several challenges and obstacles arise, such as the need to learn a lot from various sources that have been provided, such as when training/workshops are held.
Eksplorasi faktor-faktor penentu kompetensi profesional guru MTs: Perspektif supervisi, pengalaman, dan disiplin kerja
Authors: Mursyidah Any , Tsurayya Layli
Published: March 2024

Purpose − The purpose of this research was to determine (1) the contribution of principals academic supervision, teaching experience, and work discipline on the professional competencies of MTs teachers. 2) the contribution of school principals' academic supervision to the professional competence of MTs teachers. (3) the contribution of teaching experience to the professional competencies of MTs teachers. (4) the contribution of work discipline to the professional competence of MTs teachers.

Method − This study was correlative descriptive study with quantitative approach followed. The population of this study were 220 MTs teachers in Buleleng regency. The samples of this research were taken by proportional cluster random sampling of 135 MTs teacher. Data collection used questionnaire for the school supervisor’s academic  supervision variables, teaching experience, work discipline and teacher professional competence. In this study, validity testing of the instrument was using person’s product moment correlation while the reliability test used Alpha Cronbach. Data analysis used by the researcher was multiple regression analysis..

Findings − Based on the result of the study, it has shown that: 1) There was a significant contribution between of headmaster academic supervision variables, teaching experience and work dicipline simultaneous to the professional competence of MTs teachers in Buleleng Regency. 2) There was a significant positive contribution between the principals academic supervision on the teacher’s professional competence of MTs teachers in Buleleng Regency. 3) There was a significant positive contribution between teaching experience on the teacher professional competence of MTs teachers in Buleleng Regency. 4) There was a significan positive contribution between work discipline on teacher professional competence of MTs teachers in Buleleng Regency.
Cost-Aware Generalized α-Investing for Multiple Hypothesis Testing
Authors: Cook Thomas , Dubey Harsh Vardhan , Lee Ji Ah , Zhu Guangyu , Zhao Tingting , Flaherty Patrick
Published: March 2024

We consider the problem of sequential multiple hypothesis testing with nontrivial data collection costs. This problem appears, for example, when conducting biological experiments to identify differentially expressed genes of a disease process. This work builds on the generalized α-investing framework which enables control of the marginal false discovery rate in a sequential testing setting. We make a theoretical analysis of the long term asymptotic behavior of α-wealth which motivates a consideration of sample size in the α-investing decision rule. Posing the testing process as a game with nature, we construct a decision rule that optimizes the expected α-wealth reward (ERO) and provides an optimal sample size for each test. Empirical results show that a cost-aware ERO decision rule correctly rejects more false null hypotheses than other methods for $n=1$ where n is the sample size. When the sample size is not fixed cost-aware ERO uses a prior on the null hypothesis to adaptively allocate of the sample budget to each test. We extend cost-aware ERO investing to finite-horizon testing which enables the decision rule to allocate samples in a non-myopic manner. Finally, empirical tests on real data sets from biological experiments show that cost-aware ERO balances the allocation of samples to an individual test against the allocation of samples across multiple tests.
Korea Pathfinder Lunar Orbiter (KPLO) Operation: From Design to
Initial Results
Authors: Jeon Moon-Jin , Cho Young-Ho , Kim Eunhyeuk , Kim Dong-Gyu , Song Young-Joo , Hong SeungBum , Bae Jonghee , Bang Jun , Yim Jo Ryeong , Kim Dae-Kwan
Published: March 2024

Korea Pathfinder Lunar Orbiter (KPLO) is South Korea’s first space
exploration mission, developed by the Korea Aerospace Research Institute. It
aims to develop technologies for lunar exploration, explore lunar science, and
test new technologies. KPLO was launched on August 5, 2022, by a Falcon-9 launch
vehicle from cape canaveral space force station (CCSFS) in the United States and
placed on a ballistic lunar transfer (BLT) trajectory. A total of four
trajectory correction maneuvers were performed during the approximately
4.5-month trans-lunar cruise phase to reach the Moon. Starting with the first
lunar orbit insertion (LOI) maneuver on December 16, the spacecraft performed a
total of three maneuvers before arriving at the lunar mission orbit, at an
altitude of 100 kilometers, on December 27, 2022. After entering lunar orbit,
the commissioning phase validated the operation of the mission mode, in which
the payload is oriented toward the center of the Moon. After completing about
one month of commissioning, normal mission operations began, and each payload
successfully performed its planned mission. All of the spacecraft operations
that KPLO performs from launch to normal operations were designed through the
system operations design process. This includes operations that are
automatically initiated post-separation from the launch vehicle, as well as
those in lunar transfer orbit and lunar mission orbit. Key operational
procedures such as the spacecraft’s initial checkout, trajectory
correction maneuvers, LOI, and commissioning were developed during the early
operation preparation phase. These procedures were executed effectively during
both the early and normal operation phases. The successful execution of these
operations confirms the robust verification of the system operation.
Evaluating the model of multi : Global Navigation Satellite Systems (GNSS) constellation to mitigate the multipath signals
Authors:   , Madonsela Bhekinkosi Pheneas
Published: March 2024

The Global Navigation Satellite Systems (GNSS) are evolving continuously
and are being used in many applications across the world. The GNSS is used
in electrical industries, the banking sector, the agricultural sector, the
transportation and logistics sectors, etc. The architecture and operation of the
GNSS is made up of three subdivisions: the space section, control section,
and user section. The space segment consists of the satellite constellation to
generate and emit the GNSS code phase and carrier phase signals. The space
segment further stores and broadcasts the navigation data that is uploaded to
the system by the GNSS controllers. For accurate Position, Velocity and Time
(PVT), the satellite constellation must have at least three or four satellites
visible to the GNSS receiver. The control segment is also known as the ground
segment and is accountable for the complete operations of the GNSS. The
ground segment further controls and preserves the conformation files of the
satellite constellation, updates the navigation data to all satellites, controls the
atomic clock of the GNS, and predicts the satellite ephemeris. The user
segment is made up of GNSS receivers; their purpose is to receive the GNSS
signal that contains the code phase and carrier phase to determine the
pseudorange and other observables. There numerous issues that obstruct the
application of the GNSS across all sectors mentioned above; those are signal
attenuation in the satellite channels, signal diffraction, and signal multipath.
Hence, this thesis focused on mitigating the GNSS multipath signal by
investigating the concept of Combined Signal Detection (CSD). The purposes
was to reduce the impact of signal degradation and further enable the GNSS
receivers to withstand the signal degradation in deep rural areas. There are
numerous existing methodologies to mitigate multipath signal and improve the
positioning, velocity and timing in urban areas. However, the proposed CSD
approach provided the better performance by using the vector detection of all
visible satellites to improve (DP) Direct Positioning , High Sensitivity (HS) and
clock bias. Furthermore, the capabilities of the Global Positioning Systems (GPS) and
Galileo satellites are integrated to accommodate the adoption of CSD concept.
The CSD concept require the GNSS receiver that is capable of processing
multi-frequencies. The multi-constellation GNSS receiver use numerous
satellites that are in space, such as Global Positioning Systems (GPS)
satellites, BeiDou satellites, Galileo satellites, and Glonass satellites.
However, the similarities between the constellations is investigated before the
system is integrated for multi-constellation. The concept of CSD proved to be
capable of mitigating the signal multipath without introducing an external
device or circuit. This thesis further provided the comprehensive analysis of
sources that contribute towards the signal degradation
ЭФФЕКТИВНОСТЬ ТЕХНОЛОГИИ ВЫРАЩИВАНИЯ ТЕЛОК МОЛОЧНОГО НАПРАВЛЕНИЯ
Authors: Шайкенова Шайкенова Қ. Х. , Каменов М. Т.
Published: March 2024

В данной статье представлены результаты научных исследований по выращиванию телок голштино-фризской породы от рождения до плодотворного осеменения
ВЛИЯНИЕ ГУСТОТЫ СТОЯНИЯ НА ПРОДУКТИВНОСТЬ ГИБРИДОВ КУКУРУЗЫ СЕЛЕКЦИИ KAZSEEDS В УСЛОВИЯХ ФЕДОРОВСКОГО РАЙОНА КОСТАНАЙСКОЙ ОБЛАСТИ
Authors: Сабит Д. , Кипшакбаева Г. А. , Байкунирова А. , Бузовский К. П. , Сидорик А. И.
Published: March 2024

В статье представлены результаты изучения влияния предуборочной густоты стояния гибридов кукурузы Лола и Алия на элементы продуктивности (масса зерна с 1 початка, урожайность зерна, масса початка, выход зерна) и влажность зерна. Анализ показал, что диапазон густоты посевов гибрида Лола от 54 до 70 тыс. раст./га не сильно влияет по всем изученным параметрам урожайности. У гибрида Алия прослеживается зависимость от густоты стояния по структурным элементам как урожайность, влажность, масса зерна и початка. С увеличением густоты посева увеличивается влажность – 33,5%, уменьшается урожайность – 57,59 ц/га, масса зерна с 1 початка при стандартной влажности – 97,5 г, масса початка – 129 г.
ҚАПШАҒАЙ СУҚОЙМАСЫ МЕН ІЛЕ ӨЗЕНІНІҢ ИХТИОФАУНАСЫНЫҢ ҚАЗІРГІ ЖАҒДАЙЫ
Authors: Токсабаева Б. С. , Исбеков Қ. Б. , Байбатшанов М. К. , Баринова Г. К. , Рамазан Қ. Б.
Published: March 2024

Мақалада Қапшағай суқоймасы мен Іле өзенінде мекен ететін балық түрлері және олардың су айдындарында таралу ареалы қарастырылған. Іле өзенінің гидрологиялық режимі, жерсіндірілген балықтардың санына әсер ететін экологиялық факторлар туралы мәліметтер келтірілген. Балықтардың саны мен қорын қорғау, өсімін молайту жөнінде қазіргі кезде жасалып жатқан жұмыстар жөнінде қарастырылған. Сонымен қатар Қапшағай суқоймасындағы сирек кездесетін және жойылу қаупі бар балықтар туралы да қарастырылған.

         Жасалған зерттеу жұмыстарының нәтижесінде Қапшағай су қоймасы мен су қоймаға дейінгі Іле өзеніндегі сирек кездесетін және жойылу қаупі бар балықтардың популяциясы, таралуы, кездесу жиілігі анықталып, бұрынғы жылдардағы мәліметтермен салыстырылып, жағдайы бағаланды.

         Қапшағай суқоймасында 2022 жылғы 01 шілдеден 2023 жылғы 01 шілдеге дейінгі кезеңде балық аулаудың шекті рұқсат етілген мөлшері биологиялық сипаттамаларының көрсеткіштеріне және әрбір түрдің популяциялық құрылымының жалпы жағдайына негізделеді. Балықтардың жекелеген түрлері бойынша максималды рұқсат етілген аулауды бағалау кезінде тұрақты даму көрсеткіштері және сақтық шараларының қағидаттары ескерілді. Бұл ретте есептеуге негіз ретінде белгіленген немесе ұсынылған балық аулау шарасы, жетілген балықтардың жасы, сондай-ақ әрбір жас тобындағы жетілген балықтардың пайызы алынды.
Lichen amyloidosis with combined topical therapy: a case report
Authors: Made Sanitca Indah  , Ni Made Dwi Puspawati  , Herman Saputra
Published: March 2024

Introduction: Lichen amyloidosis (LA) is a rare case, characterized by circumscribed, highly pruritic, hyperkeratotic, and hyperpigmented papules occurring typically over the shins, outer aspects of upper arms, and on the upper back with amyloid deposits in the papillary dermis. Several therapeutic strategies, including topical steroids, oral antihistamines, cyclosporine, retinoids, laser, phototherapy, cryosurgery, and surgical interventions, have been reported as treatment options for patients with LA, but no standardized treatment has been established.

Case report: A 58-year-old man came to the Dermatovenereology Outpatient Department complaints of itchy blackish-brown papules on the shins. Dermatology examination found discrete multiple hyperpigmentation papules and plaque covered with white scale. A scar-like center surrounded by brownish circles or white edges was found from the dermoscopic examination. The histopathological examination found thickened keratin with compact orthokeratosis and hyaline materials in the papillary dermis with dendritic melanophages. The patient diagnosed with LA and treated by combining desoximetasone cream 0.25% with 3% salicylic acid. The papules on the legs had flattened in the patient, with a significant improvement in the severe itching after three weeks.

Conclusion: Combination therapy of potent corticosteroids and keratolytic seems to be an appropriate modality and well-tolerated by LA patients. Skin lesion becomes thinner, and pruritus is reduced.
Glucocorticoid-induced hyperglycemia (GIH) in pemphigus vulgaris patient at Bangli District General Hospital: A case report
Authors: Ni Kadek Setyawati  , A. A. I. A. Nindya Sari  , Pande Agung Mahariski
Published: March 2024

Background: Pemphigus vulgaris (PV) is an autoimmune disease characterized by mucocutaneous blistering and erosion. This is rare, but greatly affects the patient’s life quality and often cause complication of disease and therapy. Hyperglycemia is a complication due to steroid use called glucocorticoid-induced hyperglycemia (GIH). This case report describes hyperglycemia in PV treatment, which later can be a consideration of PV management.

Case: A 44-year-old male patient complained of painful lesions on almost the whole body with a form of bullae, erosion, crusting, brittle, the Nikolsky sign (+), and Asboe-Hansen sign (+). The patient was diagnosed with PV. After he had supportive therapy and high-doses of methylprednisolone, his blood sugar is increased. Patients diagnosed by hyperglycemia state due to steroid use, then given insulin as therapy. The patient diagnosed with PV based on history taking and physical examination, but the histopathologic examination wasn’t done due to lack of modality at the hospital. The steroid was given as an immunosuppressive. Be the main therapy for PV, steroids lead hyperglycemia due to disruption of glucose metabolism, thereby increasing insulin resistance in tissues. The diagnosis of hyperglycemia due to steroid use is made in a patient with a normal sugar level before PV therapy. It occurred within the first 1-2 days of therapy. In these patients, diagnosis confirmed by increasing pre-prandial, 2 h post-prandial, and any-time glucose level, after two days methylprednisolone administration. Collaboration with internal medicine colleagues is needed.

Conclusion: PV treatment with steroids can induce hyperglycemia, which is dangerous. The understanding mechanism is needed to make early detection and provide therapy properly.
Focus on the dabrafenib, vemurafenib, and trametinib in the clinical outcome of melanoma: A systematic review and meta-analysis
Authors: Ida Ayu Widya Anjani  , Anak Agung Bagus Putra Indrakusuma  , I Gede Krisna Arim Sadeva  , Putri Ayu Wulandari  , Luh Made Mas Rusyanti  , Prima Sanjiwani Saraswati Sudarsa  , I Gede Putu Supadmanaba  , Desak Made Wihandani
Published: March 2024

Background: Melanoma is the most severe lethal skin cancer, affecting melanin producer cells (melanocytes). Surgery is the most common treatment, whereas, for the advanced stage, the development of treatment is recommended. BRAF (Dabrafenib and Vemurafenib) inhibitor or MEK inhibitor (Trametinib) is the most frequently targeted melanoma therapy due to more than 80% of patients with positive BRAF mutation. In this review, those treatments will be investigated systematically to identify their clinical outcome.

Method: This systematic literature review (SLR) was performed from Cochrane, Science Direct, Google Scholar, and Pubmed. Cochrane Risk-of-Bias Tool RoB2 is used to assess RCT studies and New-castle Ottawa Scale Assessment to assess cohort studies by three different assessors. Data analysis was carried out by using Review Manager (RevMan 5.4). Heterogenicity test was assessed by I2  and Chi2 statistic

Result: There are 20 studies used in this article (13 RCT and seven cohorts). The overall survival (OS) and progression-free survival (PFS) of the survey that using targeted therapy (vemurafenib, trametinib, or dabrafenib) compare other treatments (chemotherapy, immunotherapy, etc.) showed risk ratio (RR) was 1.12 (95%CI 1.07,1.17;  I2=100%; p<0,00001). The OS and PFS with monotherapy compare of vemurafenib, trametinib, or dabrafenib with combination therapy showed RR was 1.09 (95%CI.06,1.13; I2=99%; p<0,00001). 

Conclusion: BRAF and MEK targeted therapy has a good prognosis for a patient with a positive BRAF gene mutation and could be combined with other treatments for better clinical outcomes rather than monotherapy.
Secondary syphilis with stage III HIV in an adolescent deaf male with a history of sexual relationship with men: a case report
Authors: Tritya Mudita  , Ni Made Dwi Puspawati  , I Gusti Ayu Agung Sattwika  , Andrew Yoshihiro Wirya
Published: March 2024

Introduction: Syphilis is an infection caused by Treponema pallidum of the spirochaete family.

Case: A 19-year-old Balinese came with a complaint of red spots on the palms of the hands and feet one month ago. The patient has a hearing disability and is currently enrolled in a special-needs school in Denpasar. VDRL examination with reactive results with titer 1:256 and TPHA reactive with TPHA titer 1:5120. The patient received benzathine penicillin G 2.4 million units intramuscularly. Significant improvement was obtained, and the serological test was decreased.

Discussion: Syphilis transmits through sexual contact, vertically from pregnant women to their fetuses, through needle sharing. People with hearing disabilities and adolescents are considered vulnerable as objects of harassment and sexual violence.

Conclusion: People with disabilities and adolescents are vulnerable to sexually transmitted diseases. Information on reproductive health and sexually transmitted diseases need to be more readily available for people with disabilities. Secondary syphilis therapy with a single dose of benzathine penicillin is effective from clinical or serological observations.
Low plasma level of insulin-like growth factor – I (IGF-I) is a risk factor for multibacillary type of leprosy
Authors: Luh Made Mas Rusyati  , Made Swastika Adiguna  , Indra Teguh Wiryo
Published: March 2024

Introduction: Leprosy is one of infectious diseases with complex issues. The previous study showed poverty, malnutrition, lack of proper food and nutrient intake, as well as low income. Recently, many studies reported insulin-like growth factor-I (IGF-I) as an excellent nutrient marker.

Objective: This study aims to prove that low plasma level of insulin-like growth factor-I is a risk factor for the multibacillary type of leprosy.

Material and methods: This case-control study design involved 38 patients with leprosy subjects as cases and 38 control subjects. The sample collection is done by consecutive sampling and has fulfilled the inclusion and exclusion criteria, which matched by age and gender in Dermatovenereology Polyclinic of Sanglah Hospital. The collected data was analyzed using SPSS version 23.0 with Pearson Chi-square test to obtain the odds ratio.

Results: This study showed that IGF-I plasma levels in the case group were significantly lower than the control group (p<0,05) with Odds ratio for IGF-I plasma 34,61 (95% CI= 7,17-167,01, p<0,001)

Conclusion: Low plasma level of insulin-like growth factor-I is a risk factor for the multibacillary type of leprosy.
The effect of epetraborole on the transcriptome and proteome profiles of an Escherichia coli strain overexpressing leuS, Leucyl-tRNA Synthetase
Authors: Babayeva Anara , Dibek Esra , Sünnetçi Akkoyunlu Deniz , Çine Naci , Kasap Murat , Akpınar Gürler , Çöl Bekir
Published: March 2024

Epetraborole (EP) is a boron-containing antibiotic known for its effectiveness against gram-negative enteric bacteria and Mycobacterium species. It is designed to bind and inhibit the LeuS enzyme (Leucyl-tRNA Synthetase), which is encoded by the essential gene leuS in Escherichia coli. EP inhibits protein translation, impeding bacterial growth. However, when leuS is overexpressed in a recombinant plasmid, the amount of EP required for growth inhibition needs to be increased. This study explored the impact of EP on the transcriptome and proteome of E. coli overexpressing leuS, aiming to reveal additional gene and pathway insights beyond LeuS, shedding light on the biochemical players orchestrating the bacterium’s molecular response. 2D-PAGE Proteomics analysis identified four differentially regulated proteins influenced by EP in the leuS overexpression strain. Notably, LeuA and DeoA emerged as identified proteins. EP may affect LeuA in the cells overexpressing LeuS, which could result in truncated LeuA protein variants. Transcriptomics analyses, based on microarray data, revealed 23 up-regulated and 9 down-regulated genes responding to EP in the overexpression strain (p2). Based on the statistical analyses, the first five up-and down-regulated genes showing the highest fold differences in their mRNA levels are yiaW, mglB, narH, ybiO, flgB and yhdY, deoR, recX, yobB, potF, respectively. Analyses using the Omics Dashboard pathway and String indicate that the EP effect on the leuS overexpressing strain mainly induces alterations in the expression of genes related to the cell exterior, regulation, and response to stimuli. It is suggested that EP and higher levels of LeuS may interfere with the translational and transcriptional regulation of the expression of the leuA gene, which encodes the first enzyme, 2-isopropylmalate synthase, in L-leucine biosynthesis. This study offers new insights into the effects of EP on the bacterium, specifically when the level of the aminoacyl-tRNA synthetase LeuS is increased.
Respon M. M. Azami Terhadap Orientalis Berkaitan Dengan Otentitas Hadis
Authors: Amelia Rizqa , Rahayu Sri Ulfa
Published: March 2024

Among the several views on Hadith studies that have emerged and are quite controversial are those originating from orientalists who state that the authenticity of hadiths is not as pure as what Muslims have believed so far, on the consideration that none of the Prophet's Hadiths are purely authentic from the Prophet, especially the hadiths of the Prophet hadith with ahad narration. Which then seems to explain that, it is rather difficult to believe the hadith literature as a whole as an authentic record of all the sayings and practices that originate from the Prophet Muhammad saw. Even among Muslims, there are groups that claim to believe in the Al-Qur'an, but are against the hadith of the Prophet. This polemic naturally invites various reactions from Muslim researchers, especially those who are concerned with Hadith studies. One of them is M. M. Azami, a leading hadith researcher. M.M. Azami found that the doubts expressed by orientalists regarding the sanad system were due to their methodological errors in studying the study of sanad material, because in general they did not study the chain of transmission based on the main books of hadith, but based on the main books of hadith, the fiqh and sirah which are arranged in a different way from the books of hadith. M.M. Azami responds to the views of orientalists and proves the authenticity of hadith in several ways, including: explaining the method of writing the Prophet's hadith, the system for transmitting the Prophet's Hadith, the system of using sanad, reasoning criticism, and comparative methods
Studi Ḥadīṡ Tentang Larangan Mencabut Uban Dengan Pendekatan Ilmu Kesehatan (Kajian Takhri Al- Ḥadīṡ)
Authors: Amir Sulaiman Muhammad , Munandar Munandar , Nazmi Khairin
Published: March 2024

Gray hair is no longer a taboo, many parents and even teenagers have gray hair. This is due to several factors. Some are due to age, pigment and hormone factors and other causes. The presence of visible gray hair makes people uncomfortable and feel less confident. Therefore, many people choose to pluck the gray hair on their heads. Whereas in several Ḥadīths of the Apostle it is said that gray hair is a noble thing when it grows on a person's head, and it will be a light for him on the Day of Judgment. The type of research used in this study is library research. Where data collection is obtained from examining books related to this discussion, then analyzed using the takhrij method, sanad criticism and matan criticism and using the ma'ani al-Ḥadīth approach to the meaning of the Ḥadīth. Based on the research conducted by the author, it is found that the Sanad and Matan of this Hadīth are recognized as Hasan, so it can be used as an evidence, so it can be determined that the matan of the Hadīth narrated by Abu Dawud above is Hasan because there is no shuzuz and illat in the matan of the Hadīth. Based on the medical perspective, it is also recommended not to pluck gray hair because it can cause several harmful effects including increasing the risk of infection and scarring, ingrown hair, changes in hair texture, impaired hair growth, hair loss, thinning hair to baldness and folliculitis
Analisis Pemahaman dan Implementasi Nilai-nilai Multikulturalisme dalam Hadis Sebagai Landasan untuk Membangun Harmoni Sosial di Era Globalisasi
Authors: Marbun Siti Kholidah
Published: March 2024

This research aims to analyze the understanding and implementation of multiculturalism values in the sayings of Prophet Muhammad (peace be upon him) as a foundation for building social harmony in the era of globalization. The research methodology used is a descriptive-analytical method, which involves collecting data from primary and secondary sources, followed by analyzing the collected data. Primary data is gathered from hadith collections related to multiculturalism, while secondary data is obtained from literature such as journals and books relevant to the topic under discussion. The results of this research indicate that the multiculturalism values analyzed by the author encompass three aspects: human equality, tolerance, and fair behavior within Human Rights. Additionally, there are efforts to enhance the understanding and implementation of multiculturalism values, such as through (1) education and religious understanding by integrating multicultural values into ethics and social interactions related to justice, unity, equal rights, tolerance, and mutual assistance, (2) interfaith dialogue that can be facilitated through the Bottom-Up Religious Harmony Forum (FKUB), involving religious figures and community members, (3) dissemination of positive information by providing character education to teach how to detect fake news and reduce the spread of fake news and hate speech in society, and (4) cross-cultural understanding that can be developed as an additional skill when adapting to a region, enabling communication and interaction with peers from different cultural backgrounds. However, the article also identifies several challenges, such as lack of religious understanding, religious fanaticism, structural injustice, and the rising extremism and intoleranceIn the era of globalization, where changes and complexities occur within society, the multiculturalism values present in the hadiths become increasingly important in building social harmony and maintaining interfaith coexistence. Therefore, the understanding and implementation of multiculturalism values within the hadiths need to be continually enhanced and disseminated to the entire community.
History of the Western Balkans GatewayA Geostrategic Consideration of Slovenian Territory
Authors: Prebilič Vladimir , Guštin Damijan
Published: March 2024

Monografija v dvajsetih poglavjih obravnava raznolike premisleke geostrateških in vojaških vidikov slovenskega vojaškega okolja v zadnjih dveh stoletjih. Oprta na temeljito zgodovinopisno poznavanje avtorja analizirata politološke vidike nacionalne varnosti - osredotočeno na slovenski prostor in prebivalstvo, a upoštevaje dejstvo, da je bil slovenski prostor do pred 34 leti del večnacionalnih držav, ki so obsegale več kot le slovenski nacionalni prostor. Skozi monografijo se bralec seznanja z širokim diapazonom vojaških tematik, od lokalnih vidikov napoleonskih vojn, odnosa do vojne in bojevanja slovenskih ljudi v prvi svetovni vojni, vojaški ustvarjalnosti po razpadu Avstro-Ogrske in v okvirih nove jugoslovanske države, odporniškega gibanja v času druge svetovne vojne, vpetosti v jugoslovanski vojaški sistem, oblikovanja lastnih obrambnih sil med osamosvajanjem Slovenije ter njeno preraščanje v Slovensko vojsko ter več vidikov nacionalne varnosti Republike Slovenije do odnosa do bojevnikov po končanih vojnah. Delo pomembno prispeva k poznavanju pomembnih silnic razvoja slovenske družbe in države na geopolitično pomembnem prehodnem prostoru ljubljanskih vrat.
Distribution, chemical, and molecular composition of high and low molecular weight humic-like substances in ambient aerosols
Authors: Fan Xingjun , Cheng Ao , Yu Xufang , Cao Tao , Chen Dan , Ji Wenchao , Cai Yongbing , Meng Fande , Song Jianzhong , Peng Ping'an
Published: March 2024

Abstract. Humic-like substances (HULIS) encompass a continuum of molecular weight (MW) ranges, yet our understanding of how HULIS characteristics vary with MW is still limited and not well established. In this study, a combination of ultrafiltration and solid-phase extraction protocols was employed to fractionate the high MW (HMW; > 1 kDa) and low MW (LMW; < 1 kDa) HULIS fractions from ambient aerosols collected during summer and winter at a rural site. Subsequently, comprehensive characterization using total organic carbon, high-performance size exclusion chromatography (HPSEC), UV-visible (UV-vis) and fluorescence spectroscopy, Fourier transform infrared spectroscopy (FTIR), and negative electrospray ionization high-resolution mass spectrometry (ESI–HRMS) were conducted. The results revealed that HMW HULIS were dominated by larger-sized chromophores, substantially constituting a higher fraction of total organic carbon and UV absorption at 254 nm than LMW HULIS. While both HMW and LMW HULIS shared similar fluorophore types and functional groups, the former exhibited higher levels of humification and a greater presence of polar functional groups (e.g., −COOH; > C=O). HRMS analysis further unveiled that molecular formulas within HMW HULIS generally featured smaller sizes but higher degrees of unsaturation and aromaticity compared to those within LMW HULIS fractions. This observation suggests the possibility of small molecules assembling to form the HMW HULIS through intermolecular weak forces. Moreover, HMW HULIS contained a higher proportion of CHON but fewer CHO compounds than LMW HULIS. In both HMW and LMW HULIS, the unique molecular formulas were primarily characterized by lignin-like species, yet the former displayed a prevalence of N-enriched and highly aromatic species. Additionally, HMW HULIS contained more unique lipid-like compounds, while LMW HULIS exhibited a distinct presence of tannin-like compounds. These findings provide valuable insights into the distribution, optical properties, and molecular-level characteristics of HULIS in atmospheric aerosols, thereby advancing our understanding of their sources, composition, and environmental implications.