bluuebunny/crossref_metadata_2025 huggingface dataset:
Commercialization of Electric Vehicles in Hong Kong
Authors: Mo Tiande , Lau Kin-tak , Li Yu , Poon Chi-kin , Wu Yinghong , Chu Paul K. , Luo Yang
Published: January 2022

Road vehicles are responsible for air pollution in Hong Kong, and electric vehicles (EVs) are a promising alternative to internal combustion engine vehicles as the city is transitioning to clean energy. In this work, EV adoption in Hong Kong is investigated and analyzed, including the global EV markets, present EV status in Hong Kong, local challenges facing EV development, suggestions for EV promotion in Hong Kong, emerging technologies, and decommissioning of batteries and EVs. The challenges of EVs include insufficient charging infrastructures, inadequate management of public charging facilities, difficulties in EV repair and maintenance, “dead mileage” during charging, unacceptable long charging times, and limited commercial EV models. Strategies such as providing incentives and bonuses for commercial EVs, offering high-power quick-charging facilities, actively developing commercial EVs, installing more charging infrastructures for private EVs, building connections among stakeholders, encouraging the participation of the private sector to promote fee-based services, and supporting the development of innovative technologies should be implemented to promote EVs in Hong Kong. Emerging technologies for EVs such as wireless charging, smart power distribution, vehicle-to-grid and vehicle-to-home systems, connected vehicles, and self-driving are discussed. Eco-friendly decommissioning of EV batteries can be realized by recycling and second-life applications. This paper serves as a reference and guide for the sustainable and smart evolution of the transportation sector in Hong Kong and other global large cities.
Stability and Cementation of the Surrounding Rock in Roof-Cutting and Pressure-Relief Entry under Mining Influence
Authors: Yue Xizhan , Tu Min , Li Yingfu , Chang Guanfeng , Li Chen
Published: January 2022

The application of roof-cutting and pressure-relief gob-side entry retention plays a critical role in controlling the stability of the surrounding rock at the entry, easing continuity tension and improving resource recovery ratio. The excavation of the 360,803 airway in Xinji No. 1 Mine is affected by intense mining of the 360,805 working face. Hence, to address the stability problem of surrounding rock in the 360,803 airway, rock mass blast weakening theory was used in this study to analyze the blasting stress of columnar charged rock mass and obtain the radiuses of crushed, fractured, and vibration zones under uncoupled charging conditions. The reasonable array pitch, length, and dip angle of boreholes were determined according to the pressure-relief range of the blasting fracture. The migration laws of roof strata were explored based on a mechanical model of overlying roof strata structure on the working face. Subsequently, the horizon, breaking span, and caving sequence of hard roof strata were obtained to determine the roof-cutting height of this entry. On the basis of the theory of key stratum, the number of sequences at the roof caving limit stratum and hanging roof length in the goaf were calculated, the analytical solution to critical coal pillar width was acquired, the evaluation indexes for the stability of entry-protecting coal pillars were determined, and the engineering requirements for the 25 m entry-protecting coal pillars in the 360,803 airway were met. Moreover, various indexes such as roof separation fracture, displacement of surrounding rock, and loose circle of surrounding rock in the gob-side entry were analyzed. The stability and cementation status of surrounding rock in the 360,803 airway were evaluated, and tunneling safety was ensured.
Substance Use Descriptive Norms and Behaviors among US College Students: Findings from the Healthy Minds Study
Authors: Oh Hans , Besecker Megan , Huh Jimi , Zhou Sasha , Luczak Susan E. , Pedersen Eric R.
Published: January 2022

Background: Social norms have been associated with alcohol use in college populations; however, more research is needed to confirm the associations between social norms and a range of substance use behaviors during the COVID-19 pandemic. Methods: We analyzed data from the Healthy Minds Study (September 2020–December 2020), a non-probability sample administered online to college students. We used multivariable logistic regression to test for associations between respondents’ perceptions of substance use behaviors in their respective colleges and their own substance use behaviors, adjusting for age, gender, race/ethnicity, and international student status. Results: We found that those who overestimated the prevalence of alcohol use, cigarette use, cannabis use, and vaping were significantly more likely to use these substances when compared with those who did not overestimate. These associations persisted even when using different prevalence estimates of substance use, though some associations lost statistical significance when applying the survey weights to account for non-response. Conclusion: College students overestimated the prevalence of substance use in their respective colleges, even during the early stages of the pandemic when social interactions were limited, and these beliefs were associated with substance use. Future studies may test the utility of campaigns to alter perceptions of social norms and interventions that use personalized normative feedback to reduce substance use during pandemics.
Numerical Simulation of the Effect of Fire Intensity on Wind Driven Surface Fire and Its Impact on an Idealized Building
Authors: Edalati-nejad Ali , Ghodrat Maryam , Fanaee Sayyed Aboozar , Simeoni Albert
Published: January 2022

This paper presents an investigation on the effect of fire intensity of a wind driven surface fire, similar to a large wildfire, on an idealized structure located downstream from the fire source. A numerical simulation was conducted using an open source CFD code called FireFOAM, which is a transient solver for fire simulation and turbulent diffusion flames, supported by a large eddy simulation (LES) solver for incompressible flow. The numerical data were verified using the aerodynamic experimental data of a full-scale building model with no fire effects. An idealized cubic obstacle representing a simplified building with the dimension of 6 × 6 × 6 m; is considered downstream from the fire source. Different fire intensity values of the fire line representing different grassland fuels were simulated to analyse the impact of wind-fire interaction on a built area. To solve the problem, a coupled velocity and pressure method was applied through a PIMPLE scheme in FireFoam solver of OpenFoam platform. There is a good agreement between simulated results and experimental measurements with a maximum error of 18%, which confirms the validity and accuracy of the model. The results showed that by increasing the fire intensity; the velocity of the crosswind stream increases, which causes low-density air and generates an extra stream behind the fire plume. It was also found that increasing fire intensity from 10 MW/m to 18 MW/m raises the integrated temperature on the ground near the building and on the surface of the building by 26%, and 69%, respectively.
Identification and Characterization of Immunoglobulin T Heavy Chain in Large Yellow Croaker (Larimichthys crocea)
Authors: Teng Yan , Fu Qiuling , Tan Yuanzhen , Ding Yangyang , Ding Yang , Chen Xinhua
Published: January 2022

Three immunoglobulin (Ig) isotypes have been identified in teleosts, IgM, IgD, and IgT or IgZ. IgT, a new teleost Ig isotype, plays a vital role in mucosal immunity. However, information on molecular and functional characteristics of fish IgT is still limited. In this study, an IgT heavy chain (LcIgT) gene was cloned and characterized in large yellow croaker (Larimichthys crocea). Complete cDNA of LcIgT was 1930 bp in length, encoding a protein of 554 amino acids. The deduced LcIgT contains a VH region and only three CH regions (CH1, CH2, CH4), but no transmembrane region was predicted. Phylogenetic analysis showed that IgT heavy chain sequences from all fish species are grouped together. Homology comparison showed that LcIgT shares the highest amino acid identity of 58.73% with IgT heavy chain in Scophthalmus maximus. The VH domain of LcIgT has the highest identity of 72.50% with that of Scophthalmus maximus IgT. Relatively, each constant domain of LcIgT exhibits the highest amino acid identity with that of IgT in Oreochromis niloticus (67.61% identity for CH1, 61.11% identity for CH2, and 63.74% identity for CH4). LcIgT was constitutively expressed in various tissues tested, with the highest levels in mucosa-associated tissues such as gills and skin. After Cryptocaryon irritans infection, the mRNA levels of LcIgT were significantly up-regulated in the spleen (3.27-fold) at 4 d, in the head kidney (3.98-fold) and skin (2.11-fold) at 7 d, and in gills (4.45-fold) at 14 d. The protein levels in these detected tissues were all significantly up-regulated; the peak of its up-regulation was 6.33-fold at 28d in gills, 3.44-fold at 7d in skin, and 3.72-fold at 14d in spleen. These results showed that IgT response could be simultaneously induced in both systemic and mucosal tissues after parasitic infection and that IgT may be involved in systemic immunity and mucosal immunity against parasitic infection.
Extraction of Natural Gum from Cold-Pressed Chia Seed, Flaxseed, and Rocket Seed Oil By-Product and Application in Low Fat Vegan Mayonnaise
Authors: Hijazi Taha , Karasu Salih , Tekin-Çakmak Zeynep Hazal , Bozkurt Fatih
Published: January 2022

This study involves the modeling of rheological behavior of the gum solution obtained from cold-pressed chia seed (CSG), flaxseed (FSG), and rocket seed (RSG) oil by-products and the application of these gums in a low-fat vegan mayonnaise formulation as fat replacers and emulsifier. CSG, FSG, and RSG solutions showed shear-thinning flow behavior at all concentrations. The K values ranged between 0.209 and 49.028 Pa·sn for CSG, FSG, and RSG solutions and significantly increased with increased gum concentration. The percentage recovery for the G′ was significantly affected by gum type and concentrations. CSG, FSG, and RSG showed a solid-like structure, and the storage modulus (G′) was higher than the loss modulus (G″) in all frequency ranges. The rheological characterization indicated that CSG, FSG, and RSG could be evaluated as thickeners and gelling agents in the food industry. In addition, the rheological properties, zeta potential, and particle size and oxidative stability (at 90 °C) of low-fat vegan mayonnaise samples prepared with CSG, FSG, and RSG were compared to samples prepared with guar gum (GG), Arabic gum (AG), and xanthan gum (XG). As a result, CSG, FSG, and RSG could be utilized for low-fat vegan mayonnaise as fat and egg replacers, stabilizers, and oxidative agents. The results of this study indicated that this study could offer a new perspective in adding value to flaxseed, chia seed, and rocket seed cold-press oil by-product.
Goji Berry (Lycium Barbarum L.) Carotenoids Enrichment through ‘Green’ Extraction Method Improves Oxidative Stability and Maintains Fatty Acids of Yak Ghee with Microwave Heating and Storage
Authors: Agyare Anita Nkansah , An Chang Hong , Liang Qi
Published: January 2022

As the oxidation of yak ghee is inevitable and as consumer demand for natural products continues to increase, this study aimed to enrich yak ghee with goji berry carotenoids by means of green solvent extraction and determined changes in the oxidative stability and fatty acid profiles of yak ghees during microwave heating (MW-heating) and accelerated storage. An enriched ghee (GG0) was prepared by high shear dispersion and ultrasound-assisted extraction, while a control ghee (FG0) was prepared by heating and filtration; both ghees were stored at 65 °C for 30 days and were microwave-heated (MW-heating) at 180 °C (15 and 30 min) and 200 °C for 30 min. The results showed that the carotenoid enrichment increased the oxidative stability of yak ghee during MW-heating and storage. The initial CLA and PUFA values of GG0 were not significantly different from those of FG0; SFA increased, and MUFA and TFA decreased. There was a faster rate of UFA loss and an increase in SFA and TFA in FG0 during MW-heating and storage. This indicated a protective effect of carotenoid enrichment on yak ghee. Therefore, the findings in this study support the use of goji berry carotenoids as a natural colorant and antioxidant in yak ghee. This study provides vital information for dairy processors and marketers.
Sodium Reduction by Partial and Total Replacement of NaCl with KCl in Serbian White Brined Cheese
Authors: Miocinovic Jelena , Miloradovic Zorana , Radovanovic Mira , Sredovic Ignjatovic Ivana , Radulovic Ana , Nastaj Maciej , Sołowiej Bartosz G. , Tomasevic Igor
Published: January 2022

Cheese has been listed as one of four priority food groups intended for salt reduction reformulation. The present study aimed to investigate the possibility of producing Serbian white brined cheese (Homoljski Sir) with half of NaCl, three quarters of NaCl and all NaCl replaced with KCl (Na50, Na25 and Na0, respectively). Basic composition, proteolysis and texture profile parameters were monitored during 60 days of ripening. At the end of ripening, an acceptance test was conducted by untrained consumers (N = 46). According to the cluster analysis based on hedonic scores, three clusters emerged: male consumers (47.8%), agreeable consumers (30.4%) and highly educated female consumers (21.8%). Both partial and a total salt replacement had no effect on the course of proteolytical changes, the texture and basic composition during ripening. Female consumers did not accept any level of salt substitution, while male consumers showed dislike only for the Na0 cheese. Almost 80% of all consumers liked moderately-to-very-much the Na25 cheese variant. It implies that it is worth considering the production of cheese with 50–75% of NaCl replaced with KCl. The addition of natural flavoring and clear labeling of the sodium reduction should accompany the salt replacement strategy.
Physicochemical, Microbial, and Volatile Compound Characteristics of Gochujang, Fermented Red Pepper Paste, Produced by Traditional Cottage Industries
Authors: Ramalingam Srinivasan , Bahuguna Ashutosh , Lim SeMi , Joe Ah-Ryeong , Lee Jong-Suk , Kim So-Young , Kim Myunghee
Published: January 2022

Gochujang, fermented red pepper paste, is a grain-based Korean traditional food. The quality of gochujang produced by cottage industries is not well-documented. Thus, the present study aimed to analyze the quality of gochujang from 35 traditional cottage industries for physicochemical and microbial characteristics, along with volatile compound contents. In addition to microbial characteristics, salinity, pH, free amino nitrogen, and alcohol content were evaluated. Ethanol was detected as the predominant alcohol and 57% of tested gochujang products harbored >1% of total alcohol content, which was above the recommended level for halal products. Gochujang products contained hexadecanoic and linoleic acids predominantly and several volatile compounds belonging to the classes of alcohols, aldehydes, alkanes, nitrogen-containing compounds, and terpenes. A wide range of aerobic mesophilic bacteria (2.79–8.73 log CFU/g) and yeast counts (1.56–7.15 log CFU/g) was observed. Five distinct yeast species were identified, including Zygosaccharomyces rouxii. Eight gochujang products were found to be contaminated with Bacillus cereus (>4 log CFU/g). This study suggests that there is a need to limit B. cereus contamination in cottage industry products and reduce alcohol content to comply with halal food guidelines.
Characterization Techniques Coupled with Mathematical Tools for Deepening Asphaltene Structure
Authors: Apicella Barbara , Ciajolo Anna , Carpentieri Andrea , Popa Ciprian , Russo Carmela
Published: January 2022

Asphaltenes are the heavy fraction of fossil fuels, whose characterization remains a very difficult and challenging issue due to the still-persisting uncertainties about their structure and/or composition and molecular weight. Asphaltene components are highly condensed aromatic molecules having some heteroatoms and aliphatic functionalities. Their molecular weights distribution spans in a wide range, from hundreds to millions of mass units, depending on the diagnostic used, which is mainly due to the occurrence of self-aggregation. In the present work, mass spectrometry along with size exclusion chromatography and X-ray diffraction analysis have been applied to asphaltenes for giving some further insights into their molecular weight distribution and structural characteristics. Relatively small polycyclic aromatic hydrocarbons (PAHs) with a significant degree of aliphaticity were individuated by applying fast Fourier transform (FFT) and double bond equivalent (DBE) number analysis to the mass spectra. X-ray diffraction (XRD) confirmed some aliphaticity, showing peaks specific of aliphatic functionalities. Size exclusion chromatography indicated higher molecular weight, probably due to the aliphatic substituents. Mass spectrometry at high laser power enabled observing a downward shift of molecular masses corresponding to the loss of about 10 carbon atoms, suggesting the occurrence of aryl-linked core structures assumed to feature asphaltenes along with island and archipelago structures.
Quintessential Inflation: A Tale of Emergent and Broken Symmetries
Authors: Bettoni Dario , Rubio Javier
Published: January 2022

Quintessential inflation provides a unified description of inflation and dark energy in terms of a single scalar degree of freedom, the cosmon. We present here a comprehensive overview of this appealing paradigm, highlighting its key ingredients and keeping a reasonable and homogeneous level of details. After summarizing the cosmological evolution in a simple canonical case, we discuss how quintessential inflation can be embedded in a more general scalar-tensor formulation and its relation to variable gravity scenarios. Particular emphasis is placed on the role played by symmetries. In particular, we discuss the evolution of the cosmon field in terms of ultraviolet and infrared fixed points potentially appearing in quantum gravity formulations and leading to the emergence of scale invariance in the early and late Universe. The second part of the review is devoted to the exploration of the phenomenological consequences of the paradigm. First, we discuss how direct couplings of the cosmon field to matter may affect neutrinos masses and primordial structure formation. Second, we describe how Ricci-mediated couplings to spectator fields can trigger the spontaneous symmetry breaking of internal symmetries such as, but not limited to, global U(1) or Z2 symmetries, and affect a large variety of physical processes in the early Universe.
A New Calcareous Nannofossil Record from the Lower Jurassic of Kermanshah, Western Iran: Implications for Biostratigraphy and Evolutionary Reconstructions
Authors: Abdi Asad , Mattioli Emanuela , Bádenas Beatriz
Published: January 2022

Calcareous nannofossils are used here for the first time in order to establish a precise biostratigraphic framework for the Kermanshah Radiolarite Formation, an outcropping in Western Iran. The new data presented here challenge the previous tentative age interpretations (Pliensbachian to early Toarcian) based upon radiolarians. Calcareous nannofossil assemblages and events unequivocally indicated that the pelagic limestones and marls are late Sinemurian in age (NJT 3b nannofossil subzone), and that these are thrusted over shales and cherts dated as uppermost Sinemurian (NJT 3b-c nannofossil subzone) and lowermost Pliensbachian (NJT 4 nannofossil zone). This result leads not only to reconsideration of the age of the radiolarite formations, which are widespread in the Zagros orogenic system, but also a better understanding of the stratigraphic relationships between the various lithological units known in the area. Besides these new stratigraphic inferences, the calcareous nannofossil assemblages of the uppermost Sinemurian–lowermost Pliensbachian successions revealed the common presence of new morphologies of the Mitrolithus genus, never described before. These findings allow for the description of three new species, M. montgolfieri, M. pseudonannoconus, and M. tethysiensis, and reveal the existence of homeomorphy between the spine structure of conical Lower Jurassic coccoliths and the widespread Cretaceous nannoconids.
Acknowledgment to Reviewers of Geriatrics in 2021
Authors:   Geriatrics Editorial Office
Published: January 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
Alternating Attention and Physical Fitness in Relation to the Level of Combat Training
Authors: Jamro Dariusz , Zurek Grzegorz , Lachowicz Maciej , Lenart Dariusz , Dulnik Malgorzata
Published: January 2022

The level of combat training (CT) of the future commander-leader is of critical importance to the armed forces in national defense. This study aimed to search for the relationship between the level of alternating attention, physical fitness and shooting accuracy (SA), and academic achievements in practical military subjects (PMS). The study group consisted of 137 cadets of the Military University of Land Forces. The measure of alternating attention in the study was the Color Trails Test results. Motor components were assessed by measuring hand static strength, endurance run, and time of a speed and agility run. SA and PMS were taken as measures of cadets’ CT. Significantly higher PMS were associated with higher levels of strength and better endurance in cadets. The physical fitness of the cadets did not significantly affect the cadets’ SA. The main result of the study is the revelation of the level of alternating attention as a strong determinant of cadets’ SA. The authors suggest that the main emphasis should be put on the physical preparation of a modern soldier, focused on the development of strength and endurance skills. It is also reasonable to introduce cognitive stimulation exercises to shooting training.
Improving the Biocontrol Potential of Endophytic Bacteria Bacillus subtilis with Salicylic Acid against Phytophthora infestans-Caused Postharvest Potato Tuber Late Blight and Impact on Stored Tubers Quality
Authors: Lastochkina Oksana , Pusenkova Liudmila , Garshina Darya , Kasnak Cemal , Palamutoglu Recep , Shpirnaya Irina , Mardanshin Il’dar , Maksimov Igor
Published: January 2022

Potato (Solanum tuberosum L.) tubers are a highly important food crop in many countries due to their nutritional value and health-promoting properties. Postharvest disease caused by Phytophthora infestans leads to the significant decay of stored potatoes. The main objective of this study was to evaluate the effects of the endophytic bacteria, Bacillus subtilis (strain 10–4), or its combination with salicylic acid (SA), on some resistance and quality traits of stored Ph. infestans-infected potato tubers. The experiments were conducted using hydroponically grown potato mini-tubers, infected prior to storage with Ph. infestans, and then coated with B. subtilis, alone and in combination with SA, which were then stored for six months. The results revealed that infection with Ph. infestans significantly increased tuber late blight incidence (up to 90–100%) and oxidative and osmotic damage (i.e., malondialdehyde and proline) in tubers. These phenomena were accompanied by a decrease in starch, reducing sugars (RS), and total dry matter (TDM) contents and an increase in amylase (AMY) activity. Moreover, total glycoalkaloids (GA) (α-solanine, α-chaconine) notably increased in infected tubers, exceeding (by 1.6 times) permissible safe levels (200 mg/kg FW). Treatments with B. subtilis or its combination with SA decreased Ph. infestans-activated tuber late blight incidence (by 30–40%) and reduced oxidative and osmotic damages (i.e., malondialdehyde and proline) and AMY activity in stored, infected tubers. Additionally, these treatments decreased pathogen-activated GA accumulation and increased ascorbic acid in stored tubers. Thus, the results indicated that endophytic bacteria B. subtilis, individually, and especially in combination with SA, have the potential to increase potato postharvest resistance to late blight and improve tuber quality in long-term storage.
Sprint Performance and Mechanical Force-Velocity Profile among Different Maturational Stages in Young Soccer Players
Authors: Fernández-Galván Luis Miguel , Jiménez-Reyes Pedro , Cuadrado-Peñafiel Víctor , Casado Arturo
Published: January 2022

The aim of the present study was to determine the influence of maturation status on the components of the sprint force-velocity (F-V) profile in young soccer players. Sixty-two young male soccer players from the same professional soccer academy took part in the present study. A cross-sectional design was implemented to compare the main components of the sprint F-V profile (i.e., maximal theoretical force (F0), velocity (V0), power (Pmax), and ratio of horizontal-to-resultant force (RFpeak), and decrease in the ratio of horizontal-to-resultant force (DRF)) and sprint performance (5, 20, and 30 m sprint time) among participants’ maturation stages (i.e., pre-, mid- and post-peak height velocity (PHV) groups). The results show that the ES of differences in 5 min sprint performance, F0, and RFpeak (i.e., strength- and acceleration-related components of the sprint F-V profile) were greater between pre- and mid-PHV groups than those between mid- and post-PHV groups (i.e., large and very large effects (1.24 ≤ ES ≤ 2.42) vs. moderate, small, and zero effects (0 ≤ ES ≤ 0.69), respectively). However, the ES of differences in V0 and DRF (i.e., peak speed-related components of the sprint F-V profile) were greater between mid- and post-PHV groups than those between pre- and mid-PHV groups (i.e., large effects (1.54 ≤ ES ≤ 1.92) vs. moderate effects (−0.59 ≤ ES ≤ 1), respectively). Once the strength development is achieved to a great extent from the pre- to mid-PHV groups, specific strength training methods may be used for young soccer players to improve their sprint performance.
Deep Learning for the Automatic Quantification of Pleural Plaques in Asbestos-Exposed Subjects
Authors: Benlala Ilyes , De Senneville Baudouin Denis , Dournes Gael , Menant Morgane , Gramond Celine , Thaon Isabelle , Clin Bénédicte , Brochard Patrick , Gislard Antoine , Andujar Pascal , Chammings Soizick , Gallet Justine , Lacourt Aude , Delva Fleur , Paris Christophe , Ferretti Gilbert , Pairon Jean-Claude , Laurent François
Published: January 2022

Objective: This study aimed to develop and validate an automated artificial intelligence (AI)-driven quantification of pleural plaques in a population of retired workers previously occupationally exposed to asbestos. Methods: CT scans of former workers previously occupationally exposed to asbestos who participated in the multicenter APEXS (Asbestos PostExposure Survey) study were collected retrospectively between 2010 and 2017 during the second and the third rounds of the survey. A hundred and forty-one participants with pleural plaques identified by expert radiologists at the 2nd and the 3rd CT screenings were included. Maximum Intensity Projection (MIP) with 5 mm thickness was used to reduce the number of CT slices for manual delineation. A Deep Learning AI algorithm using 2D-convolutional neural networks was trained with 8280 images from 138 CT scans of 69 participants for the semantic labeling of Pleural Plaques (PP). In all, 2160 CT images from 36 CT scans of 18 participants were used for AI testing versus ground-truth labels (GT). The clinical validity of the method was evaluated longitudinally in 54 participants with pleural plaques. Results: The concordance correlation coefficient (CCC) between AI-driven and GT was almost perfect (>0.98) for the volume extent of both PP and calcified PP. The 2D pixel similarity overlap of AI versus GT was good (DICE = 0.63) for PP, whether they were calcified or not, and very good (DICE = 0.82) for calcified PP. A longitudinal comparison of the volumetric extent of PP showed a significant increase in PP volumes (p < 0.001) between the 2nd and the 3rd CT screenings with an average delay of 5 years. Conclusions: AI allows a fully automated volumetric quantification of pleural plaques showing volumetric progression of PP over a five-year period. The reproducible PP volume evaluation may enable further investigations for the comprehension of the unclear relationships between pleural plaques and both respiratory function and occurrence of thoracic malignancy.
Body Image, Medication Use, and Mental Health among Women with Fibromyalgia in Flanders, Belgium
Authors: Van Overmeire Roel , Vesentini Lara , Vanclooster Stephanie , Muysewinkel Emilie , Bilsen Johan
Published: January 2022

Fibromyalgia (FM) is a chronic illness that does not have clear physical consequences, yet research shows that FM patients often have a low body image. An online cross-sectional study was conducted in Flanders, Belgium, among FM women who are connected to the Flemish League for fibromyalgia patients. An adjusted Body Image Scale (BIS) was used to assess body image, the General Health Questionnaire-12 (GHQ-12) was used for mental health, and the Visual Analogue Scale Fibromyalgia Impact Questionnaire (VASFIQ) was used for FM symptoms. Medication use was assessed by using a 4-point Likert scale. Time since diagnosis and age was assessed. A total of 103 women with FM responded. Linear regression showed that BIS was best predicted in a model by using VASFIQ, GHQ-12, time since diagnosis, and sleep medication, wherein only the GHQ-12 was significant as a variable (B = 0.292; p = 0.009). This model explained 19.3% of the variance. The role of sleep medication use disappeared when controlling for mental health. Mental health was more clearly associated with body image than medication use, or even fibromyalgia symptoms. Thus, having negative mental health is associated with a negative body image. In order to improve the body image of FM patients, symptom control alone is not enough; improving mental health is equally important.
“We Are Young, We Run Free”: Predicting Factors of Life Satisfaction among Young Backpackers
Authors: Refaeli Tehila , Weiss-Dagan Shlomit , Levy Drorit , Itzhaky Haya
Published: January 2022

Although research from a positive psychology perspective is conducted among different populations, few studies have examined the predictors of life satisfaction among young backpackers. The current study focused on young adults (ages 21–30), an age group for whom backpacking treks are a growing phenomenon, during their treks in the Far East and South America. Direct and indirect models were used to identify personal factors and environmental resources contributing to life satisfaction. After at least one month abroad, 318 young adults (M = 23.76) answered a self-report quantitative questionnaire. The findings show that personal resources, social support, and community participation were positively associated with life satisfaction, and risk-taking behaviors were negatively associated with life satisfaction. Social support and community participation partially mediated the association between risk-taking behaviors and life satisfaction and between personal resources and life satisfaction. The implications of the findings for the subjective well-being of young backpackers during their transition to adulthood include, among others, the need to help young backpackers maintain their personal and social resources as valuable assets for coping with challenges during their trips. It is also important to increase awareness of the possible wide-ranging negative effects of risk-taking behaviors during backpacking trips.
Performing One-Session Cognitive Stimulation to Interact with Patients with Dementia in a Hospital for Mood Improvement: A Retrospective Single-Arm Cohort Study
Authors: Tsuchiya Kenji , Saito Miku , Okonogi Naoto , Takai Saori , Jingu Yoko , Tanaka Koji , Hirao Kazuki , Fujita Takaaki , Tanaka Yukiko
Published: January 2022

Developing support and an environment for patients with dementia in hospitals is important. This study aims to assess the immediate effect of one-session cognitive stimulation intervention on the mood of patients with dementia in a hospital as preliminary evidence. This study included 33 female patients. The cognitive stimulation intervention was conducted in the day room of the hospital ward by two occupational therapists. The patients participated in one or more sessions. The cognitive stimulation intervention was designed to discuss current affairs that implicitly stimulate memory, executive function, and language skills, according to the cognitive stimulation definition. Outcomes were evaluated using a two-dimensional mood scale. The primary outcome was pleasure. The before and after session scores for the first session and the average score before and after each session at multiple times were compared. The patients’ pleasure showed significant improvements in both analyses. These results may indicate that one-session Cognitive stimulation intervention in a hospital effectively improves a mood of pleasure immediately. This study is the first report to provide preliminary evidence on the beneficial alterations of mood after one-session cognitive stimulation intervention for patients with dementia in hospitals. Cognitive stimulation intervention may be an effective non-pharmacotherapy for these patients.
Safety and Efficacy of DOACs in Patients with Advanced and End-Stage Renal Disease
Authors: Rogula Sylwester , Gąsecka Aleksandra , Mazurek Tomasz , Navarese Eliano Pio , Szarpak Łukasz , Filipiak Krzysztof J.
Published: January 2022

The prevalence of chronic kidney disease (CKD) is increasing due to the aging of the population and multiplication of risk factors, such as hypertension, arteriosclerosis and obesity. Impaired renal function increases both the risk of bleeding and thrombosis. There are two groups of orally administered drugs to prevent thromboembolic events in patients with CKD who require anticoagulation: vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs). Although VKAs remain the first-line treatment in patients with advanced CKD, treatment with VKAs is challenging due to difficulties in maintaining the appropriate anticoagulation level, tendency to accelerate vascular calcification and faster progression of CKD in patients treated with VKAs. On the other hand, the pleiotropic effect of DOACs, including vascular protection and anti-inflammatory properties along with comparable efficacy and safety of treatment with DOACs, compared to VKAs observed in preliminary reports encourages the use of DOACs in patients with CKD. This review summarizes the available data on the efficacy and safety of DOACs in patients with CKD and provides recommendations regarding the choice of the optimal drug and dosage depending on the CKD stage.
Climate Change Impacts on Microbiota in Beach Sand and Water: Looking Ahead
Authors: Brandão João , Weiskerger Chelsea , Valério Elisabete , Pitkänen Tarja , Meriläinen Päivi , Avolio Lindsay , Heaney Christopher D. , Sadowsky Michael J.
Published: January 2022

Beach sand and water have both shown relevance for human health and their microbiology have been the subjects of study for decades. Recently, the World Health Organization recommended that recreational beach sands be added to the matrices monitored for enterococci and Fungi. Global climate change is affecting beach microbial contamination, via changes to conditions like water temperature, sea level, precipitation, and waves. In addition, the world is changing, and humans travel and relocate, often carrying endemic allochthonous microbiota. Coastal areas are amongst the most frequent relocation choices, especially in regions where desertification is taking place. A warmer future will likely require looking beyond the use of traditional water quality indicators to protect human health, in order to guarantee that waterways are safe to use for bathing and recreation. Finally, since sand is a complex matrix, an alternative set of microbial standards is necessary to guarantee that the health of beach users is protected from both sand and water contaminants. We need to plan for the future safer use of beaches by adapting regulations to a climate-changing world.
In Vitro Study to Assess Effective Cleaning Techniques for Removing Staphylococcus aureus from Menstrual Cups
Authors: Wunsch Nadine , Green Stefan J. , Adam Sebastian , Hampton Janie , Phillips-Howard Penelope A. , Mehta Supriya D.
Published: January 2022

Background: We sought to determine the effectiveness of common cleaning procedures in eliminating S. aureus from silicone menstrual cups. Methods: In this in vitro study, we tested four cleaning techniques: (1) cold water; (2) cold water and liquid soap; (3) cold water followed by steeping the cup in boiled water for 5 min in a ceramic mug covered with a small plate; and (4) cold water and soap followed by steeping the cup in boiled water as in (3). Human blood was coated to the inner and outer surface of each cup, dried, and incubated with 106S. aureus colony-forming units (CFU/mL). All tests were performed in triplicate. Viable bacterial abundance was measured with decadic dilution and drop plate or surface plating. Results: Bacteria were most effectively eliminated by cleaning cups with soap and water and then steeping in boiled water (0 CFU/cup vs. 2.075 × 108/cup no cleaning, p = 0.005). This was not statistically significantly different from washing cups with water only and steeping 5 min in boiled water (14 CFU/cup). Raised lettering on the outer surface of the menstrual cups resulted in more bacterial recovery from pieces with lettering than without lettering. Conclusions: These results advance knowledge of between-period menstrual cup cleaning recommendations, suggesting that the logistical challenges of continuous boiling may be eliminated with steeping at least 5 min.
“It Is Difficult to Always Be an Antagonist”: Ethical, Professional, and Moral Dilemmas as Potentially Psychologically Traumatic Events among Nurses in Canada
Authors: Ricciardelli Rosemary , Johnston Matthew S. , Bennett Brittany , Stelnicki Andrea M. , Carleton R. Nicholas
Published: January 2022

Aims: We explore social and relational dynamics tied to an unexplored potentially psychologically traumatic event (PPTE) that can impact nurses’ well-being and sense of their occupational responsibilities: namely, the moral, ethical, or professional dilemmas encountered in their occupational work. Design: We used a semi-constructed grounded theory approach to reveal prevalent emergent themes from the qualitative, open-ended component of our survey response data as part of a larger mixed-methods study. Methods: We administered a national Canadian survey on nurses’ experiences of occupational stressors and their health and well-being between May and September 2019. In the current study, we analyzed data from four open text fields in the PPTE section of the survey. Results: In total, at least 109 participants noted that their most impactful PPTE exposure was a moral, professional, and/or ethical dilemma. These participants volunteered the theme as a spontaneous addition to the list of possible PPTE exposures. Conclusions: Emergent theme analytic results suggest that physicians, other nurses, staff, and/or the decision-making power of patients’ families can reduce or eliminate a nurse’s perception of their agency, which directly and negatively impacts their well-being and may cause them to experience moral injury. Nurses also report struggling when left to operationalize patient care instructions with which they disagree. Impact: Nurses are exposed to PPTEs at work, but little is known about factors that can aggravate PPTE exposure in the field, impact the mental wellness of nurses, and even shape patient care. We discuss the implications of PPTE involving moral, professional, and ethical dilemmas (i.e., potentially morally injurious events), and provide recommendations for nursing policy and practice.
Use of Prescribed Drugs to Treat Chronic Diseases during Pregnancy in Outpatient Care in Switzerland between 2014 and 2018: Descriptive Analysis of Swiss Health Care Claims Data
Authors: Gerbier Eva , Graber Sereina M. , Rauch Marlene , Marxer Carole A. , Meier Christoph R. , Baud David , Winterfeld Ursula , Blozik Eva , Surbek Daniel , Spoendlin Julia , Panchaud Alice
Published: January 2022

Evidence on the use of drugs during pregnancy in Switzerland is lacking. We aimed to evaluate the utilisation of drugs to treat chronic diseases during pregnancy in Switzerland. We identified all pregnancies (excluding abortions) in Swiss Helsana claims data (2014–2018). In those, we identified all claims for drugs to treat a chronic disease, which typically affects women of childbearing age. Potentially teratogenic/fetotoxic drugs were evaluated during specific risk periods. Results were demographically weighted relative to the Swiss population. We identified claims for ≥1 drug of interest during 22% of 369,371 weighted pregnancies. Levothyroxine was most frequently claimed (6.6%). Antihypertensives were claimed during 5.3% (3.9% nifedipine in T3). Renin–Angiotensin–Aldosterone System (RAAS) inhibitors were dispensed to 0.3/10,000 pregnancies during trimester 2 (T2) or trimester 3 (T3). Insulin was claimed during 3.5% of pregnancies, most frequently in T3 (3.3%). Exposure to psychotropic drugs was 3.8% (mostly Selective serotonin reuptake inhibitors (SSRIs)) and to drugs for obstructive airway diseases 3.6%. Traditional immunosuppressants (excluding corticosteroids) were claimed during 0.5% (mainly azathioprine and hydroxychloroquine), biologic immunosuppressants (Tumour necrosis factor-alpha (TNF-alpha) inhibitors and interleukin inhibitors) during 0.2%, and drugs to treat multiple sclerosis during 0.09% of pregnancies. Antiretrovirals were claimed during 0.15% of pregnancies. Patterns of drug claims were in line with treatment recommendations, but relatively rare events of in utero exposure to teratogenic drugs may have had severe implications for those involved.
Spatial Transformation Characteristics and Conflict Measurement of Production-Living-Ecology: Evidence from Urban Agglomeration of China
Authors: Chen Yu , Su Xuyang , Wang Xuekai
Published: January 2022

The land development by human beings has changed from the initial small-scale and low-level transformation to the comprehensive utilization of large-scale and high-intensity implementations. The contradiction between production-living-ecology space (PLES) has become increasingly prominent while drawing land dividends. As one of the important birthplaces of Chinese civilization and the ecological barrier in the northern region, the rapid urbanization and industrialization of the Yellow River Basin (YRB) make the ecological environment very fragile, and the imbalance of land and space development is extremely serious. Therefore, according to the multifunctional characteristics of land use, this paper establishes a classification system of production space (PS), living space (LS) and ecology space (ES), and discusses the spatiotemporal evolution and conflict distribution characteristics of the PLES with the help of the transfer matrix and spatial conflict index (SCI). The results are as follows. In 1990–2020, agricultural production space (APS), grassland ecology space (GES) and other ecology space (OES) yielded the largest proportion of PLES in the YRB. However, compared with 1990, the area of these spatial types decreased in 2020, while the urban living space (ULS) expanded rapidly. The distribution pattern of PLES was generally consistent, and the transformation between PLES in Ningxia, central Inner Mongolia, Loess Plateau and downstream areas was relatively intense. The conflict index of PLES showed an upward trend, but it was generally in a controllable range. The stable and controllable areas were concentrated in the upstream of the urban agglomeration, and the midstream and downstream were basic out of control and seriously out of control, respectively.
Assessing Trauma Center Accessibility for Healthcare Equity Using an Anti-Covering Approach
Authors: Chea Heewon , Kim Hyun , Shaw Shih-Lung , Chun Yongwan
Published: January 2022

Motor vehicle accidents are one of the most prevalent causes of traumatic injury in patients needing transport to a trauma center. Arrival at a trauma center within an hour of the accident increases a patient’s chances of survival and recovery. However, not all vehicle accidents in Tennessee are accessible to a trauma center within an hour by ground transportation. This study uses the anti-covering location problem (ACLP) to assess the current placement of trauma centers and explore optimal placements based on the population distribution and spatial pattern of motor vehicle accidents in 2015 through 2019 in Tennessee. The ACLP models seek to offer a method of exploring feasible scenarios for locating trauma centers that intend to provide accessibility to patients in underserved areas who suffer trauma as a result of vehicle accidents. The proposed ACLP approach also seeks to adjust the locations of trauma centers to reduce areas with excessive service coverage while improving coverage for less accessible areas of demand. In this study, three models are prescribed for finding optimal locations for trauma centers: (a) TraCt: ACLP model with a geometric approach and weighted models of population, fatalities, and spatial fatality clusters of vehicle accidents; (b) TraCt-ESC: an extended ACLP model mitigating excessive service supply among trauma center candidates, while expanding services to less served areas for more beneficiaries using fewer facilities; and (c) TraCt-ESCr: another extended ACLP model exploring the optimal location of additional trauma centers.
Childlessness: Concept Analysis
Authors: Gouni Olga , Jarašiūnaitė-Fedosejeva Gabija , Kömürcü Akik Burcu , Holopainen Annaleena , Calleja-Agius Jean
Published: January 2022

The purpose of this concept analysis is to explore childlessness and provide understanding to professionals involved in the field of infertility. Walker and Avant’s method was used to identify descriptions, antecedents, consequences, and empirical referents of the concept. A model with related and contrary cases was developed. The analysis was based on the definition of the term in major dictionaries in the Greek, Lithuanian, Finnish, Maltese, and Turkish languages, while further literature searches utilized the Web of Science, PubMed, PsychInfo, Medline, Google Scholar, and National Thesis Databases. The literature search was limited to papers/books published in the authors’ national languages and English. As a result, childlessness is defined as the absence of children in the life of an individual, and this can be voluntary or involuntary. However, the deeper analysis of the concept may be preceded and amplified through cultural, psychological, biological, philosophical, theological, sociological, anthropological, and linguistic aspects throughout history. These elements presented challenges for childless individuals, ultimately influencing their choices to resort to alternative ways of becoming parents, such as in vitro fertilization (IVF), surrogacy, adoption, or other forms of childbearing. Historically, childlessness has been viewed with negative connotations due to its potential impact on the survival of the human species. This negativity can be directed even to individuals who may decide to opt to voluntarily remain childfree. The long-term impact of the experience, both on an individual and collective level, continues to cause pain to those who are involuntarily childless. In conclusion, health professionals and other stakeholders who have a deep understanding of childlessness, including the antecedents and attributes, can minimize the potential negative consequences of those factors contributing to childlessness, whether voluntary or involuntary. In fact, they can capitalize on a powerful impact of change adaptation by providing support to those in their practice to recover the lost homeostasis.