bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a mechatronic thread trimmer
Authors: Novikov Y.V. , Krasner S.Y.
Published: October 2022

In the production of clothing and footwear, machine tools and semi-automatic machines are widely used. Sewing enterprises and factories of art products are partially equipped with single-needle semi-automatic embroidery machines with microprocessor control modules. Their main equipment is non-automated universal lockstitch sewing machines, chain sewing machines, zigzag stitch machines, in which embroiderers manually move the hoop with the workpiece during the embroidery process. One of the promising areas for improving sewing processes and multi-color embroidery is their automation through the use of mechatronic modules in the equipment used and semi-automatic embroidery machines. On equipment with mechatronic modules, the main operations are performed automatically, which reduces their labor intensity and improves the appearance of products due to higher stitching accuracy. The possibility of simultaneous maintenance of several semi-automatic machines by one operator increases labor productivity. A method for designing a mechatronic module for a thread trimming mechanism is proposed, which is based on calculated and experimental recommendations when designing new semi-automatic embroidery machines or upgrading those used in industrial enterprises.
Method for estimating the operating time in the compressor mode of a reciprocating hybrid power machine with regenerative heat exchange
Authors: Shcherba V.E.
Published: October 2022

The influence of the average wall temperature on the main consumption and energy characteristics of a reciprocating hybrid power machine (RHPM) with regenerative heat exchange has been studied. A significant effect of a change in the average wall temperature on the supply coefficient and the indicator isothermal efficiency of the RHPM operating in the compressor mode is shown. Based on the results obtained, a method has been developed for determining the operating time of the RHPM in the compressor mode, based on the given average value of the indicator isothermal efficiency in the studied interval of the average temperature of the wall of the surface of the working chamber, or the operating time of the RHPM.
St. Thomas Aquinas in Ukrainian Orthodox Schools
Authors: Sodomora Pavlo
Published: October 2022

Ukrainian philosophical thought has been developing under the influence of several philosophical streams. Being influences by Orthodox tradition mainly, Church has always been at the forefront of any political campaign conducted on Ukrainian terrain. The level of education plays a key role in the process of cultural development of any country.  Western part of Ukraine, comparing to its Eastern counterpart, had better access to education and information due to Catholic Church predominance in the region. The article intends to investigate the scholastic and patristic thought and its reproduction by Ukrainian cultural environment via various European teaching systems. Ukraine has been developing in a broad European context and this is why it could not have been deprived of influential teachings. But Russian imperialistic, and later communist ideology was hindering constantly the deployment and development of many ideas that were important for European philosophy. Together with Eastern theology, which was based mainly on works of Damascenus, Aristotelian traditions were introduced in Ukrainian schools gradually, and based on Aristotle’s works, theology of St. Thomas was taught.  Prominent Ukrainian thinkers were influenced by many scholastic philosophers, including St. Thomas Aquinas. Aquinas’ influence is apparent in later thinkers.
New Соnсeрts in Nutrасeutiсаls аs Аlternаtive fоr Better Heаlth
Authors: Parihar Shweta
Published: October 2022

Nutrасeutiсаls аre fооds thаt hаve been fоrtified оr enriсhed tо рrоvide аll оf the vitаl elements needed tо sustаin gооd heаlth. Numerоus reseаrсhes hаve reveаled thаt nutrасeutiсаls mаy hаve а link tо diet аnd heаlth. This аrtiсle рrоvides а brief оverview оf nutrасeutiсаl сlаssifiсаtiоns derived frоm vаriоus sоurсes, reаsоns fоr the revоlutiоn in nutrасeutiсаls, соmmerсiаlly аvаilаble nutrасeutiсаls, edible vассines develорed frоm nutrасeutiсаls, rоle оf reseаrсh аnd develорment аgenсy in nutrасeutiсаls, gоvernment аgenсies thаt tооk eye оn the nutrасeutiсаl's соmраnies, limitаtiоns оf nutrасeutiсаls. The аim оf the review аrtiсle is tо аwаre рeорle, students аbоut nutrасeutiсаls, sо thаt mоre аnd mоre reseаrсh wоrk shоuld be dоne tо рrоvide benefits fоr the sосiety.
Сlimаte Сhаnge: Effeсts оn Аgriсulture, Mitigаtiоn аnd Аdарtаtiоn Strаtegies in Indiа
Authors: Сhirаnjeeb Kumаr
Published: October 2022

Сlimаte сhаnge hаs emerged аs а severe threаt tо the сurrent аgriсulture system in the wоrld, sо сrор рrоduсtiоn is deсlining, аnd bооster fасtоrs оf сrор grоwth аre deteriоrаting; thus, а сhаllenge is develорed tо feed the рорulаtiоn аt stаke. Сlimаte сhаnge leаds tо саuse vаriоus nаturаl саlаmities, hаzаrds tо humаn heаlth аnd аnimаl heаlth аnd сreаtes sосiо-eсоnоmiс аnd роlitiсаl disturbаnсes in the wоrld. The аdарtаtiоns аnd mitigаtiоn strаtegies fосus оn reduсing the emissiоns аnd greenhоuse gаses thаt leаd tо сlimаte сhаnge; аlsо, рrоtосоls аre mаde tо deаl with сlimаte сhаnge. Сlimаte сhаnge аlsо hаs а signifiсаnt imрасt оn the livelihооds оf the fаrming соmmunity. Thаt shоuld be сheсked tо ensure better stаbility аnd sustаinаbility in аgriсulture аnd оther seсtоrs fоr the grоwth оf оur соuntry.
Effeсt оf Сlimаte Сhаnge оn Sоil аnd Wаter Resоurсes with Mitigаtiоn Strаtegies fоr Sustаinаbility: А Review
Authors: Сhirаnjeeb Kumаr
Published: October 2022

Сlimаte is the lоng term bаsis shift in weаther аnd temрerаture раttern оver а раrtiсulаr regiоn. The сlimаte suрроrts the рlаnt аnd miсrоbiаl соmmunity grоwth. Still, the аdverse effeсt саn leаd tо the destruсtiоn оf miсrоbiаl аnd рlаnt diversity, intense heаtwаves, аnd lоss оf glасier levels with the rise in wаter levels саusing threаts tо the terrestriаl аnd mаrine eсоsystem with оссurrenсes оf the intense drоught оf higher frequenсies. The higher temрerаture degrаdes the sоil оrgаniс mаtter соntent, whiсh in turn deсlines the nutrient stаtus оf sоil with аlterаtiоn оf sоil рrорerties, thus hаmрering sоil heаlth соnditiоn. The сrор grоwth аnd sustаinаbility in the аgriсulturаl рrоduсtiоn system аlsо hаmрers by аffeсting рlаnt аnd miсrоbe's interасtiоns with eасh оther аnd their reduсed biоdiversity in resрeсtive eсоsystems. Wаter resоurсes рlаy а key rоle in ensuring рrорer сrор grоwth, mаintenаnсe оf sоil system, аnd рrорer biоlоgiсаl funсtiоns, аnd in resроnse tо this сlimаte сhаnge, wаter resоurсes аre degrаding. Сlimаte сhаnge аlters the enzymаtiс аnd оther key funсtiоnаries in sоil аnd аssосiаted eсоsystems; thus,, mоnitоring the the imрасt оf аdverse сlimаte effeсtseffeсts shоuld be сheсked fоr sustаinаbility in аgriсulture.
Comprehensive assessment of cardiovascular complications in a patient with type 1 diabetes mellitus, chronic kidney disease and diabetic neuroosteoarthropathy
Authors: Bondarenko Olga N. , Yaroslavceva Marianna V. , Tokmakova Alla Y. , Galstyan Gagik R. , Tarbaeva Natalia V.
Published: October 2022

The paper presents a clinical case of the patient with long-term poor control of type 1 diabetes mellitus, chronic kidney disease (CKD) and diabetic neurоosteoarthropathy. The characteristics of interest in the clinical case are CKD complications associated with mineral and bone metabolism disorders. Clinical consequences of vascular calcification due to secondary hyperparathyroidism, autonomic and peripheral neuropathy have resulted in cardiovascular complications. We discuss the diagnostic challenges of vascular calcification, as well as the interpretation of diagnostic methods in lower limb arterial disease, and provide evidence for the advantages of alternative treatment of secondary hyperparathyroidism with a selective activator of vitamin D receptors. The important role of CKD in the development of metabolic, structural and hemodynamic disorders in patients with type 1 diabetes mellitus is emphasized.
УРБАНИЗАЦИЯ И ГОРОДСКОЕ НАСЕЛЕНИЕ ГЕРМАНИИ
Authors: Таскин Фёдор Александрович
Published: October 2022

Актуальность исследования заключается в том, что процесс урбанизации оказывает большое влияние на социально-экономическое развитие Германии. Экономические и политические процессы, происходящие в стране, напрямую зависят от роста численности населения, доли разных возрастных групп в общем объёме населения, а также интенсивности миграционных процессов. Целью статьи является оценка уровня урбанизации Германии на современном этапе. Методы: сравнительно-сопоставительный анализ статистических и научных материалов.Результаты. Рассмотрены причины текущего уровня урбанизации в Германии и её типы; представлена классификация городов и муниципалитетов; приведены и проанализированы статистические показатели численности, плотности населения по всем землям Западной и Восточной Германии за 2012–2021 гг.; рассмотрено влияние внутренней и внешней миграции на плотность населения; выявлены основные причины прироста, убыли населения в отдельных землях; проанализированы произошедшие с 1990 по 2020 г. изменения процентного соотношения людей в различных возрастных группах и их влияние на численность городского населения Германии; представлены преимущества проживания в крупных и средних городах по сравнению с сельской местностью; оценены темпы прироста населения в 15 крупных городах Германии. Сформулирован вывод о высокой степени урбанизации Германии, затухании процесса субурбанизации и расширении реурбанизации; привлекательности крупных городов для проживания, которые являются точками роста и развития экономики страны; старении и сокращении численности населения Германии вследствие низкой рождаемости и частичного замедления указанных процессов за счёт притока мигрантов.
ORTAOKUL ÖĞRENCİLERİNİN ELEŞTİREL DÜŞÜNME EĞİLİMLERİ İLE ÜSTBİLİŞSEL FARKINDALIKLARI ARASINDAKİ İLİŞKİNİN İNCELENMESİ
Authors: BAKIR Tuğba , EĞMİR Eray
Published: October 2022

Bu çalışmanın amacı ortaokul öğrencilerinin eleştirel düşünme eğilimleri ile üstbilişsel farkındalıkları arasındaki ilişkiyi incelemektir. Çalışmada nicel araştırma yöntemlerinden ilişkisel tarama modeli kullanılmıştır Bu araştırmanın örneklemini 2020-2021 eğitim-öğretim yılında İstanbul ilinde öğrenim gören ve uygun örnekleme yöntemi ile belirlenen 633 ortaokul öğrencisi oluşturmaktadır. Veri toplama aracı olarak Ertaş Kılıç ve Şen (2014) tarafından geliştirilen “Eleştirel Düşünme Eğilimi Ölçeği” ve Karakelle ve Saraç (2007) tarafından geliştirilen “Çocuklar için Üstbilişsel Farkındalık Ölçeği” kullanılmıştır. Sonuç olarak ortaokul öğrencilerinin eleştirel düşünme eğilimleri ile üstbilişsel farkındalıkları arasında orta düzeyde pozitif yönlü ve anlamlı bir ilişki belirlenmiştir. Ayrıca çalışma sonucunda, ortaokul öğrencilerinin eleştirel düşünme eğilimlerinin üstbilişsel farkındalıklarını anlamlı bir biçimde yordadığı bulunmuştur.
On a new method for obtaining a guaranteed error estimate for Numerov’s method using ellipsoids
Authors: Zolotareva Natalia D.
Published: October 2022

In this article, we consider a numerical solution of the Cauchy problem for a second-order differential equation calculated by the means of the Numerov method. A new method for obtaining a guaranteed error estimate using ellipsoids is proposed. The numerical solution is enclosed in an ellipsoid containing both the exact and the numerical solutions of the problem, which is recalculated at each step. In contrast to the previously proposed method for recalculating ellipsoids, a more accurate estimate of small terms in the difference equation for the error is proposed. This leads to a more accurate estimate of the error of the numerical solution and the applicability of the proposed method to estimating the error on longer intervals. The results of estimating the error of Numerov’s method in solving the two-body problem over a large interval are presented. This numerical experiment demonstrates the effectiveness of the proposed method.
On properties of solutions to differential systems modeling the electrical activity of the brain
Authors: Lanina Anastasia S. , Pluzhnikova Elena A.
Published: October 2022

The Hopfield-type model of the dynamics of the electrical activity of the brain, which is a system of differential equations of the form
v ̇_i=-αv_i+∑_(j=1)^n▒〖w_ji f_δ (v_j )+I_i (t), i=(1,n) ̅ 〗, t≥0.
is investigated. The model parameters are assumed to be given: α>0, w_ji>0 for i≠j and w_ii=0, I_i (t)≥0. The activation function f_δ (δ is the time of the neuron transition to the state of activity) of two types is considered:
δ=0⟹f_0 (v)={■(0,&v≤θ,@1,&v>θ;) δ>0⟹f_δ (v)={■(0,&v≤θ,@δ^(-1) (v-θ),&θθ+δ.)┤ ┤
In the case of δ>0 (the function f_δ is continuous), the solution of the Cauchy problem for the system under consideration exists, is unique, and is non-negative for non-negative initial values. In the case of δ=0 (the function f_0 is discontinuous at the point θ), it is shown that the set of solutions of the Cauchy problem has the largest and the smallest solutions, estimates for the solutions are obtained, and an example of a system for which the Cauchy problem has an infinite number of solutions is given. In this study, methods of analysis of mappings acting in partially ordered spaces are used.
An improved Hopfield model is also investigated. It takes into account the time of movement of an electrical impulse from one neuron to another, and therefore such a model is represented by a system of differential equations with delay. For such a system, both in the case of continuous and in the case of discontinuous activation function, it is shown that the Cauchy problem is uniquely solvable, estimates for the solution are obtained, and an algorithm for analytical finding of solution is described.
THE EPIDEMIOLOGICAL DETERMINATION OF NOSOCOMIAL INFECTION IN INPATIENTS AT ADAM MALIK GENERAL HOSPITAL, MEDAN
Authors: Sazkiah Ema Rizka , Ismah Zata
Published: October 2022

Background: Nosocomial infection is a complication that most often occurs in hospitals and other health services. Infection is a most widely acquired hospital effect that can affect 5 to 10% of all hospitalized patients in developed countries and in low-background countries being a major burden. Objectives: This study aims to determine the epidemiological determinants of nosocomial infections in inpatients at the General Hospital of the Haji Adam Malik Center, Medan in 2019.Method: Determination of the sample size in the case and control using unpaired categorical analitical formula obtained a total sampel of 90 patients with ratio of 1:1. Data analysis using chi-square test analysis. Result: The results showed that the dominant type of infection was urinary tract infection (35.6%), the most widely used type of invasive procedure was catheters (35.6%), the most common type of germs was conditional pathogens (84.4%), and the most common type of invasive procedure was catheter treatment ≥ 7 days (64.4%). The determinants of nosocomial infection in hospitalized patients were the type of invasive action (surgery, p value 0.013 and length of stay of patients (≥ 7 days, p value 0.035). Conclusion: Performing surgery in accordance with standart operational procedure, applying surgical site infection bundles, discharging surgery patients on the fourth day, improving personal hygiene, reducing invasivtione procedures and providing antimicrobials to patients are necessary to reduce the incidence of nosocomial infections.
THE EFFECT OF NUTRITIONAL EDUCATION THROUGH POSTER MEDIA AND VIDEO ON THE IMPROVEMENT OF KNOWLEDGE ABOUT ANEMIA IN ADOLESCENT PRINCESS
Authors: May Astuti Nur Azizah , Kurniasari Ratih
Published: October 2022

Background: Nutritional anemia is a major nutritional problem in the world, including in Indonesia, which is caused by iron deficiency. Iron deficiency anemia has infected more than 600 million people worldwide and in developing countries the prevalence reaches 51%. In Indonesia, the prevalence of anemia in adolescent girls is 22.7%. The effects of anemia can cause ongoing stress and complications from fatigue. The influencing factor is the lack of knowledge of young women about anemia. Efforts to increase knowledge of young women on anemia health problems can be done through nutrition education. The purpose of this study was to determine the effect of nutrition education through posters and videos on knowledge of anemia in adolescent girls.

Methods: The research design used was quasy experimental with a pre-post test group design, which was carried out in April 2021. The research subjects were young women aged 12-18 years consisting of two groups, namely the poster media group and video media, with a total of 40 respondents. Data analysis used paired sample t-test.

Results: Based on the results of the Paired Sample T-Test, it showed that knowledge increased after education, both in the poster and video groups. There were differences in respondents' knowledge of the effect of using nutrition education media through posters (p = 0,021) and videos (p = 0,001).

Conclusion: Nutrition education has an effect on knowledge of anemia in adolescent girls, as well as more effective education through video media.
Application of Clean and Healthy Behavior Activities In the Covid-19 Pandemic in Miftahul Islamic Boarding School, South Jakarta, Indonesia
Authors: Mulyanti Mulyanti , Subur Rina Yuliana , Rahayu Sri
Published: October 2022

Introduction: The COVID-19 pandemic has hit countries around the world, including Indonesia. One of the sectors affected by the COVID-19 pandemic is the education sector. Educational institution in Indonesia has designed a distance learning program to prevent COVID-19 but not all educational institutions can implement this, for example an Islamic boarding school. The Pandemic COVID-19 causes the weakness of teaching and learning activities in islamic boarding school. However, teaching and learning activities must continue to be carried out with study times, to follow government directives in preventing the wider spread of the pandemic COVID-19. One of the ways to prevent the spread of COVID-19 is to wash your hands with soap and running water, also maintaining clean and healthy behavior activities.

Method: This study uses a qualitative method with a descriptive phenomenological approach. The sample was selected purposively, the research informants were student Islamic Boarding School Miftahul, South Jakarta and key informants consisted of boarding school leaders, teachers in the boarding school environment on November 2021.

Result: The results showed that the informants had behaved in a clean and healthy life both as an effort to prevent the covid-19 virus.

Conclusion: It is hoped that the board and management of Islamic boarding schools can coordinate with local health center health workers to conduct health education related to Clean and Healthy Behavior (PHBS).

 

 

 
The Implementation of Infection Prevention and Control at the Lubuklinggau City Community Health Center: An Observational Study
Authors: Purba Jeannita Sri Agustini , Syakurah Rizma Adlia
Published: October 2022

Introduction: Implementation of Infection Prevention and Control (IPC) is one of the characteristics of the quality of Health Care Services. Health care facilities must do the surveillance, IPC education and training. This aims to describe the implementation of IPC at the Lubuklinggau City Community Health Center (CHC).

Methods: Descriptive qualitative study with a participant observation approach used.

Result: The results showed that the priority problem was the ineffectiveness of the IPC team in implementing the IPC at the Lubuklinggau City CHC.

Discussion: The preparation stage consists of socialization of IPC technical guidelines at CHC, assistance in implementing management and organization, assistance in disseminating policies, guidelines, SOPs, IPC, and IPC indicators, IPC implementation and reporting at the Primary Healthcare Facilities level, and IPC education and information at the level of health cadres and community leaders in every Health Center. The stages of monitoring and supervision are starting from the planning, implementation, and reporting stages. Evaluation is carried out with indicators of success in the form of accuracy and completeness of the report. Reporting is done at the end of the activity. Internal constraints that may occur are constraints on organizational culture, human resources, and funds, while external constraints include regional characteristics, reinforcing factors, and changing/accelerating factors. From these possible obstacles, strategies are made to overcome them.

Conclusion: In this study, in order to further increase the effectiveness of the implementation of IPC at the Lubuklinggau City CHC, it is necessary to carry out continuous upgrading of the competence of health workers and IPC data at CHC.
The Relationship between Family Functions and the Quality of Life of the Elderly with Hypertension in the working area Public Health Center of Babadan
Authors: Oktaviani Dinta Sekar , Anggraini Merry Tiyas , Noviasari Nina Anggraeni
Published: October 2022

Background: Hypertension is still a major problem in the elderly at the Babadan Health Center, based on data in 2021 the incidence of hypertension at the Babadan Health Center is 539 cases. Due to the high rate of hypertension in the elderly, it has a negative impact on the quality of life. Elderly who suffer from hypertension need the role of a good family function in order to create a good quality of life as well. The general purpose of this study was to explain the relationship between family functions and the quality of life of elderly patients with hypertension in the working area of Babadan Health Center.

Methods: Analytical observational research with cross sectional approach and using simple random sampling technique. This research was conducted from October to December 2021 in the working area of the Babadan Health Center, Ponorogo Regency. The number of samples for this study was 67 samples with inclusion criteria and exclusion criteria. Data collection was obtained from the results of filling out the APGAR Family questionnaire and the WHOQOL-BREF questionnaire which had been tested for validity and reliability. The data obtained were analyzed with bivariat analysis used Chi-Square test.

Results: The majority of elderly people with hypertension at the Babadan Health Center have healthy family functions and a good quality of life, especially in the domain of social relations. Based on statistical analysis using the Chi-Square test, it was found that there was a significant relationship between family function and the quality of life of the elderly with hypertension (p = 0.000; PR = 8.9; CI = 95% 2.954 to 26.830).

Conclusion: Elderly people with hypertension who come from healthy families are 9 times more likely to have a good quality of life than the elderly who come from unhealthy families. The role of a good family function will affect the quality of life of elderly people with hypertension, especially in terms of social relationships.
Internal Factors Risk of Breastfeeding Failure in Infants Age 3-6 Months
Authors: Kadir Arisna , Yun Diniaty Rosidi Indah
Published: October 2022

Background: The coverage of breastfeeding in Indonesia has not yet met the target set by the government . Mother's awareness of breastfeeding in Indonesia is only 14%, and is only given until the baby is four months old. Based on these data, there are ± 86% of mothers who experience exclusive breastfeeding failure, or we can say there are 86% of mothers who give additional food/drinks other than breast milk to their babies before the age of 6 months Objective: To determine the internal factors that cause the risk of breastfeeding failure in infants 3-6 months old. Method: analytic study with case control approach . Sampling using purposive sampling technique with a sample size of 10 respondents in the case group and 10 respondents in the control group. Statistical test using fisher exact test and odds ratio. Results: Internal factors that become the risk of breastfeeding failure in infants 3-6 months are occupation (OR = 16.00), parity (OR = 2.25) and mother's knowledge (OR = 21.00). While the internal factors of age, education, nutritional status and condition of the mother have a low risk for the failure of breastfeeding for infants 3-6 months. Conclusion: Efforts to increase knowledge are needed such as education and counseling. It is hoped that there will be a lactation counselor in increasing the coverage of breastfeeding.
ANALISIS KINERJA REKSA DANA SAHAM DENGAN METODE SHARPE, TREYNOR, DAN JENSEN SELAMA MASA PANDEMI
Authors: Mumtazah Ghoziyah Inas , Permadhy Yul Tito
Published: October 2022

Reksa dana ialah alternatif instrumen pendanaan bagi investor yang mempunyai keterbatasan modal dan waktu untuk mengatur dan mengukur tingkat pengembalian serta risiko atas investasi yang dimilikinya. Pengukuran kinerja perlu dilakukan oleh pemilik modal dalam menyeleksi reksa dana, agar investasi yang dipilihnya bersifat prospektif. Studi yang dilakukan bermaksud untuk mengetahui kinerja reksa dana saham konvensional dengan metode Sharpe, Treynor, dan Jensen. Selanjutnya dibandingkan dengan performa dari benchmark. Metode penelitian menggunakan teknik deskriptif dengan pendekatan secara kuantitatif. Teknik purposive sampling digunakan dalam pemilihan sampel berdasarkan kriteria yang ditentukan, dengan jumlah akhir sampel sebesar 78 reksa dana saham. Pengukuran kinerja dengan metode Sharpe, Treynor, dan Jensen. Sedangkan, uji hipotesis dengan uji beda Kruskal Wallis. Hasil dari penelitian memberitahukan 48 reksa dana kinerjanya positif dengan metode Sharpe dan Treynor, 17 reksa dana hasilnya positif dengan metode Jensen, serta masih banyak performa reksa dana saham konvensional belum dapat mengungguli kinerja benchmark. Selain itu, kesimpulan penelitian ini tidak terdapat adanya perbedaan hasil kinerja dengan setiap metode yang digunakan, yaitu Sharpe, Treynor, dan Jensen.
Design of Work Systems in Air Cooler Production Using Work Load Analysis (WLA) and Macroergonomic Analysis and Design (MEAD) Methods at PT GIJ
Authors: Al Havish Fandra Prastyo , Putra Boy Isma
Published: October 2022

Air cooler is a system or machine designed to stabilize the air temperature and humidity in a certain area by circulating it. In the air cooler production process at PT GIJ, very high accuracy is also needed in the process and is still carried out by 1 worker in each part of the production process manually and the time it takes is relatively long up to more than 2 hours from normal time and results in employees fatigue easily. This study uses the work load analysis (WLA) method to reduce the workload obtained by completing the work at a certain working time and then improving the work system using the macroergonomic analysis and design (MEAD) method to determine the need for rest time in several production process activities. From the results of this study indicate the value of the workload after doing research using the work load analysis (WLA) method, the results of the workload at the component stage are 0.52 and the line process stage is 0.51 which means that from the stages of the production process each is declared to get a load. underload or normal work and the results obtained from the calculation of the need for rest time using the macroergonomic analysis and design (MEAD) method, the results of energy consumption are 2.52 kcal/minute and the results obtained are the need for rest time of 64.15 minutes so that the rest time needed by employees for stretching the body by 4.15 minutes outside the normal rest time of 60 minutes.
Prevention of The Use of VPN with Firewall Method Layer 7 Microtic Protocol for Negative Content Filtering and Implementation in RT/RW Net Network (Klatakan Village)
Authors: Misbahuddin Misbahuddin
Published: October 2022

The impact of negative content is still widely published in various media, the influence is in the form of pornographic content. To stay away from such content, it is always necessary to emphasize again the basic principles that must be known for using the internet. One of them is to instill healthy internet usage ethics. Internet control can be carried out in the server mechanism in each regional internet network down to the smallest server unit. The web filtering method using the layer 7 protocol feature is one method to achieve the goal of blocking some negative sites and VPNs. In this research, the implementation of web filtering was carried out on the RT/RW net network in Klatakan Pandaan Village. The network is for the benefit of the client, especially the RT/RW net of Klatakan Pandaan Village.
Design and Construction of Water Heater with Induction Method with Arduino Uno Monitoring
Authors: Fadhillah Achmad Karim , Wisaksono Arief
Published: October 2022

Induction heating is a process in which the heater and the object to be heated are not in physical contact. Therefore, several previous studies did not provide information about the effect of winding and coil diameter on the performance of induction heaters. The sensor used is the Ds18b20 sensor which detects the temperature of hot water and cold water. To increase the effectiveness of the use of heat energy through an induction heater directly, the research tool is an induction water heater. Induction heating is the generation of heat in a metal exposed to an induced magnetic field. In this process, a validated graphic temperature controller is invaluable through the monitoring process using software that can detect the hot temperature of the Blynk and 16X2 LCD. The hot water temperature generated by the induction heater allows the system to operate optimally. As a result, the capillary tube reaches a hot temperature and a constant water temperature of 38 ° C in 173 seconds. The microcontroller and flash connection detection test is working fine. This system makes it easy to carry out the temperature monitoring process via a smartphone.
Stratified support pattern-based internet-assisted self-management therapy for MCI associated with DM: a randomized controlled trial protocol
Authors: Wang Yun-xian , Lin Rong , Yan Yuan-jiao , Li Hong
Published: October 2022

Background: Mild cognitive impairment (MCI) associated with diabetes mellitus (DM) is common among elderly individuals, and self-management is critical to controlling disease progression. However, both MCI and DM are heterogeneous diseases, and existing integrated self-management interventions do not consider patient differences. Grouping patients by disease characteristics could help to individualize disease management and improve the use of available resources. The current study sought to explore the feasibility and effectiveness of a stratified support model.
Methods: A randomized controlled trial will be conducted after dividing MCI associated with DM patients into an intervention group and a control group in a 1:1 ratio. The intervention group will receive a self-management intervention using the “internet +” stratified support mode, while the control group will receive the health manual integrated intervention mode. After 12 weeks, cognitive function, blood glucose, self-management ability, and psychological status of patients in both groups will be measured and compared.
Discussion: This study developed an “internet +” stratified support mode to provide self-management intervention for patients with MCI associated with DM. The impact of different models and forms of self-management intervention on cognitive function, blood glucose management, and psychological status will be assessed. The results of this study should inform related cognitive intervention research on stratification and the internet, and help to slow the decline of cognitive function in patients with MCI associated with DM.
Trial registration: ChiCTR2200061991. Registered 16 July 2022.
Multi-omics Research on the Heterogeneity and Immune Landscape of Lung Adenocarcinoma with Ground-glass opacity
Authors: Miao Huiwen , Teng Xiao , Teng Xiaodong , Fu Shaozi , Gao Meihui , Xu Heyun
Published: October 2022

Background:
Lung adenocarcinoma with ground-glass opacity (GGO) has been detected increasingly and now accounts for most lung cancer patients. Lung adenocarcinoma with GGO contains a complex ecosystem. The mechanism of lung adenocarcinoma with GGO remains largely elusive. We use mass spectrometry proteomics combined with metabolomics to understand how these characteristics achieve a long-term functional balance and the trend of changes in tumor progression at the cellular functional level.
Methods:
We initiated a prospective cohort study to characterize lung adenocarcinoma with GGO components or without GGO components. Tumor and para-cancer tissue samples were collected. Multi-omics including transcriptomics proteomics and metabonomics were performed.
Results:
We found lung adenocarcinoma with GGO had a relatively slow proliferation tumor cells and stronger immune cell infiltration in proteomic and transcriptomic analysis. The immune cell markers expression, including CD47, CD68, CD81, CD86, C1Q, SPP1, CXCL13, ALOX5AP and HPGD was found overexpression in lung adenocarcinoma with GGO, which indicated more immune cell infiltration. In metabolomic analysis, GAPDH, ENO1 and LDHA were highly expressed in pure-solid lung adenocarcinoma, and GPD1 was highly expressed in lung adenocarcinoma with GGO. The combined transcriptome and proteome analysis revealed that proteins with consistent differences mainly included GAPDH, MKI67, AGER, and CRYM. KEGG pathway enrichment analysis showed that several aliphatic acyclic compounds expression were higher in lung adenocarcinoma with GGO.
Conclusion:
We describe a functional homeostasis in lung adenocarcinoma with GGO, which was constructed by relatively slow proliferation tumor cells and stronger immune cell infiltration. Overexpression of CXCL13 drives the infiltration of immune cells, which means the formation of anti-tumor tertiary lymphatic structures. The dysfunction of macrophage may be an important marker of this progression.
Gamma' fibrinogen levels as a biomarker of COVID-19 respiratory disease severity
Authors: Kornblith Lucy Z. , Sadhanandhan Bindhya , Arun Sreepriya , Long Rebecca , Johnson Alicia J. , Noll Jamie , Ramchand C. N. , Olynyk John K. , Farrell David H.
Published: October 2022

Coronavirus disease 2019 (COVID-19) is characterized by a pro-inflammatory state associated with organ failure, thrombosis, and death. We investigated a novel inflammatory biomarker, γ' fibrinogen (GPF), in 103 hospitalized patients with COVID-19 and 19 healthy controls. We found significant associations between GPF levels and the severity of COVID-19 as judged by blood oxygen saturation (SpO2). The mean level of GPF in the patients with COVID-19 was significantly higher than in controls (69.8 (95% CI 64.8–74.8) mg/dL compared with 36.9 (95% CI 31.4–42.4) mg/dL, p < 0.0001), whereas C-reactive protein (CRP), lactate dehydrogenase (LDH), and total fibrinogen levels were not significantly different between groups. Mean GPF levels were significantly highest in patients with severe COVID-19 (SpO2 ≤ 93%, GPF 75.2 (95% CI 68.7–81.8) mg/dL), compared to mild/moderate COVID-19 (SpO2 > 93%, GPF 62.5 (95% CI 55.0–70.0) mg/dL, p = 0.01, AUC of 0.68, 95% CI 0.57–0.78; Youden's index cutpoint 62.9 mg/dL, sensitivity 0.64, specificity 0.63). In contrast, CRP, interleukin-6, ferritin, LDH, D-dimers, and total fibrinogen had weaker associations with COVID-19 disease severity (all ROC curves with lower AUCs). Thus, GPF may be a useful inflammatory marker of COVID-19 respiratory disease severity.
Ortho-palladated complexes with aromatic N-donor ligands, synthesis, characterization, molecular structures, antibacterial and anticancer activity
Authors: Afandi Zana S. , Al-Jibori Subhi A. , Ferjani Hela , Al-Shammar Riyadh H. , Aldossari Samar Abdullah , Al-Janabi Ahmed S.
Published: October 2022

Ten newly synthesized ortho-palladated complexes of the type [PdCl(bhq)L] (1–10) (where bhp = benzo[H]quinolate, L = 2-aminobenzothiazole (2-abt), 2-amino-benzimidazole(2-abi), 2-aminothiazole(at), imidazole(im), 2-aminopyridine(2-apy), 2-amino-3-methylpyridine(2-ampy), 2-amino-5-chloropyridine(2-acpy), 3-methyl-pyridine (3-mpy), 2-methylpyridine(2-mpy)or2-pyridinemethaneamine (2-pyma) have been prepared by bridge opening reaction of dimeric [PdCl(bhq)]2 with two equivalent of various aromatic N-donor ligands(L). The prepared complexes were characterized using IR, 1H n.m.r, mass spectroscopy, molar conductance and X-ray crystallography. The result refer to that all complexes have neutral square planar shape except complex (10) is ionic have electric conductance (40µs), then approved by addition of AgNO3 solution to afford white precipitate of AgCl. The biological activity of the prepared complexes were examined against Pseudomonas aeruginosa, Escherichia coli and staphylococcus aurous. The complexes showed good to moderate activity against the three pathogenic bacteria, Further more complex 4, displays a highest anti-bacterial activity than the other complexes. Some of synthesized complexes were evaluated as anticancer, screening against A2780 and HCT-116 cell lines using the MTT colorimetric assay. The [Pd(bhq)Cl(im)] (4) complex exhibited significant cytotoxicity against the HCT-116 and A2780 cell lines with IC50 values are 8.67 ± 1.04 µM and 6.32 ± 0.86 µM for respectively.
Stability and pattern formation in a general class of reaction-diffusion-advection system
Authors: Maimaiti Yimamu , Yang Wenbin
Published: October 2022

This paper focuses on a general class of reaction-diffusion-advection system with linear cross-diffusion and cross-advection. By investigating the linearized stability of the constant equilibrium solution, we prove that the self-diffusion and self-advection terms have no effect on the stabilization of the constant steady state, the linear cross terms favor the destabilization of the constant steady state and mechanism of pattern formation. The theoretical results are applied to predator-prey and water-vegetation models with cross-diffusion and cross-advection.
Arabic Text to Image Generation Tasks
Authors: BAHANI Mourad
Published: October 2022

Current AI systems have shown impressive results in the Automatic synthesis realistic images from texts descriptions tasks. In fact, Generative Adversarial Networks (GANs) are used mostly in this tasks. The Generator generates realistic images given noise and sentence vectors, and the discriminator produce a probability of how the synthetic images are reals. In this paper, in order to generate images from Arabic text, we fuse DF-GAN as a sample and efficient text-to-image generation framework and AraBERT architecture. To achieve this purpose, firstly, we re-create new datasets matching the Arabic text-to-image generation task by applying DeepL-Translator from English to Arabic on texts descriptions of original datasets. Secondly, we leverage the power of AraBERT which is trained on billions of Arabic words to produce a strong sentence embedding, and we reduce that vector's dimension to match with DF-GAN shape. Thirdly, we inject the reduced sentence embedding into the UPBlocks sections of DF-GAN and we train the proposed architecture on two challenging datasets. Following the previous works, we use CUB and Oxford-102 flowers as original datasets. Further, we measure our framework with FID and IS. Our framework is the first that achieve much success in generating high-resolution realistic and text matching images conditioned with Arabic text.
Involvement of Proteasome and Endoplasmic Reticulum Stress in Neurodegeneration after Global Brain Ischemia
Authors: Ziakova Katarina , Kovalska Maria , Pilchova Ivana , Dibdiakova Katarina , Pokusa Michal , Kalenska Dagmar , Racay Peter
Published: October 2022

A brief period of transient global brain ischemia leads to a selective ischemic neurodegeneration associated with death of hippocampal CA1 pyramidal neurons days after reperfusion. The mechanism of such selective and delayed neurodegeneration is still uncertain. The aim of our work was to study an involvement of proteasome and endoplasmic reticulum (ER) stress in ischemic neurodegeneration. We have performed laser scanning confocal microscopy analysis of brain slices from control and experimental animals that underwent global brain ischemia in duration of 15 minutes and varying times of reperfusion. We have focused on ubiquitin, PUMA that is proapoptotic protein of Bcl-2 family overexpressed in response to both proteasome and ER stress, and p53 that controls expression of PUMA. We have also examined expression of HRD1, E3 ubiquitin ligase that was shown to be overexpressed after ER stress. Using cellular models of both proteasome and ER stress, we have examined possible crosstalk between proteasome and ER stress. We demonstrate that global brain ischemia is associated with an appearance of distinct immunoreactivity of ubiquitin, PUMA and p53 in pyramidal neurons of CA1 layer of hippocampus 72 hours after ischemic insults. Such changes corelate with a delay and selectivity of ischemic neurodegeneration. Immunoreactivity of HRD1 observed in all investigated regions of rat brain was transiently absent in both CA1 and CA3 neurones 24 hours after ischemia in hippocampus that does not correlate with a delay and selectivity of ischemic neurodegeneration. We do not document significant crosstalk between proteasome and ER stress. Our results are in favour of dysfunction of ubiquitin proteasome system and consequent p53-induced expression of PUMA as the main mechanisms responsible for selective and delayed degeneration of pyramidal neurons of hippocampal CA1 layer in response to global brain ischemia.
Effects of the coronavirus disease 2019 pandemic on anxiety and spirituality in patients with cancer undergoing chemotherapy: a cross-sectional study
Authors: Oliveira Francisca Fernanda Barbosa , Carlos Anna Clara Aragão Matos , Crispim André Alves , Coelho Lívia Moreira Caetano , Malta Cássia Emanuella Nóbrega , de Souza Thuany Pinto Rocha , Silva-Fernandes Isabelle Joyce de Lima , Silva Paulo Goberlânio de Barros
Published: October 2022

Purpose To evaluate anxiety and spirituality levels in oncology patients during the coronavirus disease 2019 (COVID-19) pandemic. Methods This short-term cross-sectional study applied a previously validated General Anxiety Disorder-7 (GAD7) scale and spirituality inventory to 230 patients undergoing antineoplastic chemotherapy during the second wave of COVID-19 in Brazil. The means ± SD of the scales were calculated and correlated (Spearman'srho). After categorization, chi-square and multinomial regression models were used to identify risk factors (p < 0.05). Results The levels of anxiety (6.16 ± 5.11) and spirituality (17.22 ± 2.66) were moderately and inversely correlated (p = 0.001, r = -0.212). Women (p = 0.025), fatigue (p = 0.048), and insomnia (p = 0.001) were associated with an increased incidence of anxiety; however, spirituality was associated with a reduced incidence of fatigue (p = 0.032). Death of family or friends due to COVID-19 increased the risk of high levels of anxiety (p < 0.05), while in multivariate analysis, insomnia (p = 0.030) and sleep difficulty (p = 0.031) were also directly associated with anxiety and spirituality reduced the interruption of chemotherapy during the COVID-19 pandemic (p = 0.036). Conclusion and Implications for Cancer Survivors: Fear of the COVID-19 pandemic altered the psychoemotional environment of patients undergoing chemotherapy, resulting in increased levels of anxiety. However, spirituality was an important coping strategy in patients undergoing cancer treatment.
Subclavian vein ultrasound-guided fluid management to prevent post-spinal anaesthetic hypotension: a randomized controlled trial
Authors: Lu Yan , Zhang Yueqi , Shen Fuyi , Xu Zhendong , Liu Zhiqiang
Published: October 2022

Background Hypotension frequently occurs after spinal anaesthesia during caesarean delivery, which is recommended to prevent by fluid loading. We evaluated subclavian vein (SCV) ultrasound (US)-guided volume optimisation in preventing hypotension after spinal anaesthesia during caesarean delivery. Methods This randomised controlled study included 80 consecutive full-term parturients scheduled for caesarean delivery under spinal anaesthesia. Women were randomly divided into the SCVUS group, comprising SCVUS analysis before spinal anaesthesia with SCVUS-guided volume management, and the control group without SCVUS assessment. Before anaesthesia, the SCVUS group received 3 mL/kg crystalloid fluid challenges repeatedly within 3 min with a 1-min interval based on the SCV collapsibility index (SCVCI), while the control group received a fixed dose (10 mL/kg). Incidence of post-spinal anaesthetic hypotension was the primary outcome. Total fluid volume, vasopressor dosage, changes in hemodynamic parameters, maternal adverse effects, and neonatal status were secondary outcomes. Results The total fluid volume was significantly higher in the control group than in the SCVUS group (690 [108] vs. 160 [280] mL, p < 0.001), while the phenylephrine dose (0 [40] vs. 0 [30] µg, p = 0.276) and incidence of post-spinal anaesthetic hypotension (65% vs. 60%, p = 0.950) were comparable. The incidence of maternal adverse effects, including nausea/vomiting and bradycardia (12.5% vs. 17.5%, p = 0.531 and 7.5% vs. 5%, p = 1, respectively), and neonatal outcomes (Apgar scores) were comparable between the groups. SCVCI correlated with the amount of fluid administered (R = 0.885, p < 0.001). Conclusions SCVUS-guided volume management did not ameliorate post-spinal anaesthetic hypotension but reduced the volume of the preload required before spinal anaesthesia. Trail registration: The trial was registered with the Chinese Clinical Trial Registry at chictr.org.cn (registration number, ChiCTR2100055050) on December 31, 2021.
Transcendental entire solutions of quadratic functional equations
Authors: Basir Molla Basir Ahamed , Sanju Sanju mandal
Published: October 2022

Solving Fermat-type functional equations is long standing problems in function theory and it is well-known that ƒ2 + g2 = 1 and ƒ2 + 2αƒg + g2 = 1 are respectively called binomial and trinomial quadratic equations. Using Nevanlinna theory as a tool, in this paper, we study existence and precise form of the solutions general quadratic functional equations aƒ2+2αƒg+bg2+2βƒ+2γg+C = 0. Moreover, we give an answer to a conjecture posed by Zhang. In addition, we obtain a result on the existence of meromorphic solutions to Fermat-type difference equations considering polynomial coefficients, which generalizes an existence result.
Mathematics Subject Classification (2010). 39B32, 30D35.
A machine learning model that identifies neoantigen-reactive CD8+ T cells in human gastrointestinal cancer
Authors: Shi Zhiwen
Published: October 2022

It appears that tumor-infiltrating neoantigen-reactive CD8 + T cells are the primary driver of immune responses to gastrointestinal cancer in patients. By mapping neoantigen-reactive T cells from the single-cell transcriptomes of thousands of tumor-infiltrating lymphocytes, we developed a 26-gene machine learning model for the identification of neoantigen-reactive T cells. In both training and test sets, the model performed admirably. We discovered, by applying the model to large-scale single-cell sequencing data of tumor-infiltrating CD8 + T cells, that Neo T cells exhibited a hyperexpanded phenotype and two distinct differentiation pathways. Moreover, compared to non-neoantigen-reactive T cells, the majority of neoantigen-reactive T cells exhibited notable differences in the biological processes of locomotion and amide metabolism. The analysis of potential cell-to-cell interactions revealed that neoantigen-reactive T cells contain potent signaling molecules, such as CXCL13 and LTA, associated with the formation of tertiary lymphoid structures. This method expedites the identification of neoantigen-reactive TCRs and the engineering of neoantigen-reactive T cells for therapy.