bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinação da atividade respiratória (CO2) em frutos de Juazeiro colhidos em cinco estádios de maturação
Authors: Costa Franciscleudo Bezerra da , Pereira Manoel Mykéias Duarte , Silva Jéssica Leite da , Nascimento Ana Marinho do , Silva Bruna Rocha da , Sales Giuliana Naiara Barros
Published: November 2020

Juazeiro (Ziziphus joazeiro Mart.) is a prominent plant in the midst of adverse conditions in Caatinga. Its fruit is small, fleshy, sweet and very perishable and it has a white pulp. This condition induces a high rate of respiration to the fruit and, therefore, interferes with its ripening. Thus, the objective of this study was to determine the quality and respiratory activity (CO2) in Juazeiro fruits. Juazeiro fruit were harvested from plants located at the Center of Science and Agri-Food Technology, at the Federal University of Campina Grande, Campus Pombal-PB, and taken to the Laboratory of Chemistry, Biochemistry and Food Analysis . The fruits were selected for the absence of damage and classified in five stages of maturation, being evaluated for pH, titratable acidity, soluble solids, soluble sugars, ascorbic acid and respiratory rate. Stage IV maturation fruits were stored under controlled temperature (25±2 ºC and 34±1% RH) for 4 days and evaluated on all storage days for respiratory rate, loss of fresh weight, titratable acidity and soluble solids. The advancement of maturation resulted in sweeter, slightly more acid juazeiro fruits and with a subtle reduction in the concentration of ascorbic acid. The highest respiratory rate was obtained in stage III maturation fruits, indicating that until this stage of maturation the fruits did not reach their full maturity, being probably in the final stage of growth. Regarding storage, there was a peak in the respiratory rate with 2 days of storage, indicating that the Juazeiro fruits present a climacteric behavior, reinforced by the responses observed in soluble solids and titratable acidity.
Sistema de Informações Geográficas para gerar mapas com a localização da Sucupira (Schinopsis brasiliensis) – margem Noroeste do município de São Francisco-MG, bacia do rio São Francisco
Authors: Camargo Pedro Luiz Teixeira , Teixeira Marcílio Baltazar , Martins Junior Paulo Pereira , Madeira Fernando Antônio , Beserra Raphaella Karla Portes
Published: November 2020

Managing natural resources responsibly is undoubtedly one of the biggest environmental management challenges. Thus, interpolation methods for generating Digital Elevation Models - DEM have been frequently used to help people make decisions. This study was carried out in the Northwest (B) bank of the municipality of São Francisco, North of Minas Gerais, located in the upper-middle São Francisco River basin, where the natural Cerrado suffered intense degradation in the 41 year interval (1975-2016). The aim of the project was to generate a map capable of presenting the populational average of Sucupira (Schinopsis brasiliensis) per collection point. We used overlapping cartographic images and the IDW tool of Arcgis 10.2 software. After the successful methodological experience presented in this article, results indicate that the overlapping mapping performed here shows Sucupira (Schinopsis brasiliensis) present basically throughout the studied margin, with the exception of the East and West ends. It is possible to highlight, however, a significant population growth in the South, exactly where the main water bodies of the place are, indicating that even though it is adapted to the entire study area, the species has a preference for humid regions. Further studies are suggested about the hypothesis proposed here for the distribution of the species throughout the Northwest region of the municipality of São Francisco.
Holographic memory updated by contradictory information: influence of low frequency attenuation on response stability
Authors:   ITMO University, Pavlov A.V.
Published: November 2020

A 6f-scheme of Fourier holography with resonant architecture is considered, which implements memory replenishment with new information that contradicts the previously recorded. It is shown that the low-frequency attenuation due to the nonlinearity of the exposure characteristics of holographic recording media in the initial reference holographic image recorded in a narrow filtering range corresponding to the degradation in the correlation plane of the global maximum of the autocorrelation function below the lateral maxima leads to the response instability – an intermittent mode. It is shown that the intermittent mode corresponds to the restructuring of the autocorrelation function of a composite standard recorded in holograms from one range of values of the approximation model parameters to another. It is shown that the correlation length of the composite image recorded in holograms is an order parameter of the system; its rapid change precedes the loss of response stability and the transition to an unstable regime with intermittency. The results of numerical simulation are presented.
Energy flux of a vortex field focused using a secant gradient lens
Authors:   IPSI RAS – Branch of the FSRC “Crystallography and Photonics” RAS, Nalimov A.G. ,   Samara National Research University
Published: November 2020

In this paper we simulated the focusing of left circular polarized beam with a second order phase vortex and a second-order cylindrical vector beam by a gradient index Mikaelian lens. It was shown numerically, that there is an area with a negative Poynting vector projection on Z axis, that can be called an area with backward energy flow. Using a cylindrical hole in the output surface of the lens and optimizing it one can obtain a negative flow, which will be situated in the maximum intensity region, unlike to previous papers, in which such backward energy flow regions were situated in a shadow area. Thereby, this lens will work as an “optical magnet”, it will attract Rayleigh particles (with diameter about 1/20 of the wavelength) to its surface.
Approaches to moving object detection and parameter estimation in a video sequence for the transport analysis system
Authors:   Ryazan State Radio Engineering University named after V.F. Utkin, Alpatov B.A. , Babayan P.V. ,   Ryazan State Radio Engineering University named after V.F. Utkin, Ershov M.D. ,   Ryazan State Radio Engineering University named after V.F. Utkin
Published: November 2020

The paper discusses different approaches to image and video processing aiming to solve the problems of detecting, tracking and estimating the parameters of moving objects. The developed algorithms for solving these problems are described in relation to the field of transport analytics. When developing the algorithms, attention was given to solving the problems on an embedded platform of video surveillance cameras, which imposes restrictions on the computational complexity. The first (basic) algorithm for moving object detection and parameter estimation is based on processing two associated areas of an image. This algorithm includes a computationally efficient adaptive procedure for evaluating and updating the background component of an image. The procedure is based on the physics of the process of movement of the object of interest through a processing zone. The second algorithm performs object tracking based on an optical flow method initialized by feature points. The third algorithm is based on object segment tracking and is computationally efficient for the implementation on an embedded platform of intelligent cameras. Results of experimental studies of the proposed algorithms are presented, as well as a comparison with some well-known algorithms. It is shown that tracking algorithms can improve the accuracy of moving object parameter estimation. Tracking also reduces the number of classification errors compared to the basic approach to object detection and parameter estimation.
Remote sensing data retouching based on image inpainting algorithms in the forgery generation problem
Authors:   Samara National Research University, Kuznetsov A.V. ,   IPSI RAS – Branch of the FSRC “Crystallography and Photonics” RAS, Gashnikov M.V. ,   Samara National Research University,   IPSI RAS – Branch of the FSRC “Crystallography and Photonics” RAS
Published: November 2020

We investigate image retouching algorithms for generating forgery Earth remote sensing data. We provide an overview of existing neural network solutions in the field of generation and inpainting of remote sensing images. To retouch Earth remote sensing data, we use image-inpainting algorithms based on convolutional neural networks and generative-adversarial neural networks. We pay special attention to a generative neural network with a separate contour prediction block that includes two series-connected generative-adversarial subnets. The first subnet inpaints contours of the image within the retouched area. The second subnet uses the inpainted contours to generate the resulting retouch area. As a basis for comparison, we use exemplar-based algorithms of image inpainting. We carry out computational experiments to study the effectiveness of these algorithms when retouching natural data of remote sensing of various types. We perform a comparative analysis of the quality of the algorithms considered, depending on the type, shape and size of the retouched objects and areas. We give qualitative and quantitative characteristics of the efficiency of the studied image inpainting algorithms when retouching Earth remote sensing data. We experimentally prove the advantage of generative-competitive neural networks in the construction of forgery remote sensing data.
Toroidal polarization vortices in tightly focused beams with singularity
Authors:   IPSI RAS – Branch of the FSRC ", Stafeev S.S. ,   Crystallography and Photonics",   RAS,   Samara National Research University, Kotlyar V.V. ,   IPSI RAS – Branch of the FSRC “Crystallography and Photonics” RAS,   Samara National Research University
Published: November 2020

In this paper, we numerically investigated tight focusing of cylindrical vector beams of the sec-ond order using Richards-Wolf formulae. It was shown that intensity rings where the Poynting vector was equal to zero appeared not only in the focal plane but also in nearby planes. For example, a lens with numerical aperture NA=0.95 was shown to generate periodical toroidal vortices with a 0.8-mkm period along the z-axis at a distance of about 0.45 mkm from the axis. The vortices were generated pairwise, with the closest-to-focus vortex having clockwise helicity and the subsequent being anti-clockwise. The vortices were also characterized by saddle points. When focusing an optical beam passed through a narrow annular aperture, no toroidal vortices were observed.
Isotopic-geochemical features of water-rock system by the example of Verkh-Tarskoe oil field
Authors:   Federal State Budgetary Scientific Institution Trofimuk Institute of Petroleum Geology and Geophysics of Siberian Branch of Russian Academy of Sciences, Vakulenko Lyudmila G. , Novikov Dmitry A. ,   Federal State Budgetary Scientific Institution Trofimuk Institute of Petroleum Geology and Geophysics of Siberian Branch of Russian Academy of Sciences, Nikolenko Ostap D. ,   Federal State Budgetary Scientific Institution Trofimuk Institute of Petroleum Geology and Geophysics of Siberian Branch of Russian Academy of Sciences, Dultsev Fedor F. ,   Federal State Budgetary Scientific Institution Trofimuk Institute of Petroleum Geology and Geophysics of Siberian Branch of Russian Academy of Sciences, Chernykh Anatoly V. ,   Federal State Budgetary Scientific Institution Trofimuk Institute of Petroleum Geology and Geophysics of Siberian Branch of Russian Academy of Sciences, Yan Peter A. ,   Federal State Budgetary Scientific Institution Trofimuk Institute of Petroleum Geology and Geophysics of Siberian Branch of Russian Academy of Sciences
Published: November 2020

The first data of a comprehensive study of the isotope-geochemical features of the water-rock system are presented on the example of the Yu 1 horizon of the Verkh-Tarsk oil field. It was established that the reservoir waters of the developed deposits are similar in the isotopic ratios and located in the same area with the waters of the Apt-Alb-Cenomanian aquifer complex (an agent for flooding). In the cement of silt-sandy rocks among the authigenic minerals most widely represented by calcite, three generations of it were established. A narrow range of δ 13 C values was revealed in the analysis of the δ 13 C - δ 18 О isotope pair. In waters it ranges from -10.5 to -9.1 ‰, and in calcites of the third generation from -10.7 to -9.1 ‰.
Potential hydrocarbon reservoirs in the neoprotherozoic of Leno-Anabar NGO
Authors:   Trofimuk Institute of Petroleum Geology and Geophysics of SB RAS, Varaksina Irina V. , Shavarov Roman D. ,   Irkutsk Oil Company
Published: November 2020

The influence of lithological factors on the formation of reservoirs in Neoproterozoic deposits was considered based on the deep drilling in the Lena-Anabar oil and gas region. It was established that the Precambrian section is represented by the alternation of packs of carbonate and terrigenous rocks and its accumulation took place in a large range of environments: from delta to sublittoral, with a significant prevalence of shallow-water sedimentation. It was discovered that potential reservoirs are present in Precambrian sediments, and the most perspective levels are related to the Vendian part of the section.
Changes in the biomarker composition of saturated fraction in late mesocatagenesis
Authors:   Institute of Petroleum Geology and Geophysics SB RAS, Dolzhenko Kirill V.
Published: November 2020

In the paper the transformations, occurring in the distribution of n-alkanes, steranes (m/z 217) and terpanes (m/z 191) hydrocarbons with a catagenesis increase, are discussed. The results obtained in the study of the superdeep well Srednevilyuyskaya-27 (Eastern Siberia) and published works on the regions of the United States of America, Germany and India were used for that comparison. The general trends in the change of the hydrocarbons individual composition of organic matter of various genetic nature with increasing thermal maturity are shown.
Biostratigraphy of the upper jurassic of the Verkh-Tarskaya drilling area (South of Western Siberia in foraminifera)
Authors:   Trofimuk Institute of Petroleum Geology and Geophysics, SB RAS, Zaychikova Ekaterina V.
Published: November 2020

The study of the taxonomic composition of foraminifera in the wells of the Verkh-Tarskaya drilling area formed the basis of this study. This made it possible to clarify the content of the complexes and trace the zones and layers with foraminifera. The biostratigraphic characteristics of the middle oxfordian-lower volgian sediments are also presented in the work, and changes in the taxonomic composition and structure of foraminifera complexes from wells in the Verkh-Tarsky district.
The Effect of Learning Experience on the Information Literacy of Students in the Ri-Png Border During Covid-19 Period
Authors: Fredy Fredy , Prihandoko Lastika Ary , Anggawirya Arin Mantara
Published: November 2020

The spread of the COVID-19 pandemic presents challenges for higher education institutions, especially in Indonesia's border areas. The transformation of face-to-face learning models to distance learning models impacts the learning experience of students, especially those who are completing writing research proposals and theses that require adequate information literacy skills. This study aims to explore the effect of student learning experiences on information literacy skills. The research data were obtained from respondents from four universities in Merauke. Purposive sampling technique is used with the criteria of students who have taken research methodology courses and are taking or have taken proposal seminar courses. One hundred respondents have filled out a questionnaire distributed online. Based on the data analysis, learning experiences contributed 17.60% to students' information literacy skills. Furthermore, each increase in student learning experiences will contribute to 0.40% of information literacy skills. These research findings can be valuable information to be developed to the next stage in making modules and learning media that can provide a good quality learning experience to improve student literacy skills, especially in writing research proposals/theses. With this module or learning media, it is hoped that it can prepare students to write research proposals and theses.
The Effect of Moodle E-Learning Material on EFL Reading Comprehension
Authors: Ismail Hijril , Rahmat Aceng , Emzir Emzir
Published: November 2020

Reading comprehension depicted as the most important skills and a complex cognitive process for the achievement of success or learning outcome in both school and society where reader’s prior knowledge and experiences serve central roles in the interpretation of a text or the interaction of the reader, the text, and the context. The purpose of the exploratory study was to investigate the effect of the Moodle e-learning on EFL reading comprehension. 27 EFL college students were participating in the study. Data were collected through the pretest and posttest of reading comprehension. Data analysis involved three stages: normality test, homogeneity test, and hypothesis testing by utilizing software statistical package for social science (SPSS) for the window. Results indicate that the use of Moodle e-learning has a significant effect on improving students’ reading comprehension.
Development of Active Learning Model Type Reading Guide Assisted with Macromedia Flash in Learning Reading Exposition Text for Grade 8th MTS / SMP Students
Authors: Hehakaya Ruth , Sastromiharjo Andoyo , Cahyani Isah
Published: November 2020

This development research was carried out to produce a reading type active learning model assisted by macromedia flash to improve students' reading comprehension skills. The active reading learning model consists of six phases, namely, conveying goals and motivating, presenting information, organizing students in groups, guiding group work and study, evaluation, and giving awards. This development research uses the 4D development model according to Thiagarajan. Product validation includes, namely (a) the feasibility of the model concept, (b) the initial design of the model, and (c) planning the development of the model, testing the properties of the data includes three ways namely normality test, homogeneity test, and t test. Product trials were carried out on six phases of the active learning model. Based on the results of validation, limited trials, and extensive trials, it can be concluded that the active learning model type reading guide assisted by macromedia flash is feasible to be applied in learning to read comprehension text exposition.
Legal Certainty of Doctor Profession Insurance Claim in Bumiputera Muda 1967 General Insurance, Pekanbaru City
Authors: Multazam Ibnu , Ismansyah Ismansyah , Fauzi Wetria
Published: November 2020

PT. Asuransi Umum Bumiputera Muda 1967 Sells an insurance product called professional medical insurance, which is included in the scope of liability insurance. Liability insurance is a type of insurance that covers material losses due to legal liability to other parties, in this case a mistake or negligence committed by a doctor in carrying out his / her duties. The problems in this thesis are how is the legal certainty in medical profession insurance claims and how is legal certainty in the implementation of medical profession insurance claims at PT. Asuransi Umum Bumiputera Muda 1967, Pekanbaru City. The method used in this thesis is a juridical empiric approach. Sources of data are primary, secondary and tertiary legal materials obtained through literature and information studies, using interview guidelines and field observations. From research done shows that the rule of law in insurance claims medical profession when there is negligence medic was not found in the positive law of Indonesia, therefore, if there had been an agreement between the parties regarding the amount of compensation and payment terms then poured into agreements or agreements made in writing, either under hand or before a notary. This agreed agreement will become the law for the parties in claiming professional insurance. Furthermore, legal certainty in the settlement of medical professional insurance claims as well as implementation and obstacles both from the insurance party, the doctor as the insured or a third party, in this case the Medicolegal team
The Effect of Strategic Planning on Entrepreneurship Strategy Requirements (The Case of Private Hospitals in Iraqi Erbil City)
Authors: Sadq Zana Majed , Ahmad Brwa Sardar , Faeq Dalia Khalid , Muhammed Hazhar Omer
Published: November 2020

This study aimed to examine the effect of strategic planning that is represented by three dimensions (top management support, technology and strategic goals) on entrepreneurship strategy requirements that is represented by three dimensions (creative capabilities, risk taking,and entrepreneurial culture) related to the perspectives of employees at private hospitals in Iraqi Kurdistan Region Erbil city. A survey questionnaire has been used to collect data, and the questionnaires distributed randomly to (150) health staff comprising of a number of private hospitals, (146) of staff were able to fill and return the questionnaires however (142) of the questionnaires was suitable for the purpose of statically analyzing. The questionnaire encompassed two sections with 30 closed-ended questions. Data collected analyzed quantitatively by using SPSS program version 20. The results of study concluded that there is a moderate and positive correlation as well as a significant impact of strategic planning on entrepreneurship strategy requirements.
Juridical Implications of Subject Limitation of Liability Rights in Electronic Services
Authors: Supriadi Deni , Sood Muhammad , Sili Eduardus Bayo
Published: November 2020

This study aims to identify the legal construction and legal implications of the limitations of the legal subject of the mortgage provider in the electronic mortgage service system, as well as the legal protection of the legal subject of the mortgage provider in the electronic mortgage service system. The theory used is the theory of legal certainty, the theory of legal norms hierarchy and the theory of legal protection. The limitation of the subject of the mortgage provider in electronic mortgage services results in a conflict of legal norms which in the Mortgage Law does not limit the subject of the mortgage provider, and results in no longer validity of third parties as providers of mortgage rights who are not debtors. Then the legal protection is not much different from the previous process of imposing mortgage rights, the difference is in technical matters regarding documents that are now being carried out using electronic documents which are also electronic evidence.
Stateof-the-art of realization of the fertility potential in the women of late reproductive age
Authors: Ermolenko Kristina S. , Radzinsky V. E. , Rapoport S. I.
Published: November 2020

Biological potential of childbearing in the women of late reproductive age is limited by natural impairment and loss of fertility. Despite a considerable progress in clinical application of new diagnostic and reproductive technologies, the problem of infertility remains a most serious challenge. Women’s age is one of the main factors responsible for the outcome of in vitro fertilization. The low effectiveness of in vitro fertilization programs is attributed to discoordination in the hypothalamic-pituitary system, depletion of ovarian resources, and deterioration of quality of reproductive material. Bearing in mind the role of melatonin in synchronizing circadian and seasonal biorhythms and regulating physiological and pathological processes, it is natural to suggest its role in the enhancement of efficiency of in vitro fertilization programs for women of late reproductive age.
Predictors of moderate cognitive disorders in patients with coronary heart disease and type 2 diabetes mellitus
Authors: Trubnikova Olga A. , Tarasova I. V. , Mamontova A. S. , Kagan E. S. , Maleva O. V. , Barbarash O. L.
Published: November 2020

Aim. To study predictors of moderate cognitive disorders (MCD) in patients with coronary heart disease (CHD) and type 2 diabetes mellitus (DM2). Materials and methods. The study included 54 men with CPD and DM2 (mean age 56.8±4.5 years). Standard medical examination was supplemented by the assessment of cognitive status, characteristics of lipid and carbohydrate metabolism. Factors allegedly influencing MCD development included the patients’ age, education level, stenosis of carotid arteries, LV ejection fraction, arterial hypertension, insulin and HbAlc levels, HOMA and QUICKI indices, lipid metabolism, concentrations of total, HDL and LDL cholesterol, fructosamine, triglycerides, severity of coronary lesions (Syntax scale), trait and state anxiety. Results. Fructosamine level and HOMA index were the most important characteristics responsible for MCD in patients with CPD and DM2. Conclusion. The data obtained demonstrate the significance of fructosamine level and HOMA index in the development of MCD in patients with CPD and DM2.
Comorbidity in rheumatoid arthritis: A focus on cardiovascular diseases
Authors: Gasparyan A. A. , Men’shikova Irina V. , Kanevskaya M. Z.
Published: November 2020

Cardiovascular diseases (CVD) in patients with rheumatoid arthritis (RA) are ranked first in the structure of comorbidity and mortality. This review includes recent data on common pathogenic mechanisms of inflammation and atherosclerosis, the impact of traditional and specific risk factors, biomarkers of CVD in RA patients. Variants of CVD in RA, the possible pathogenic mechanisms of their development and methods of diagnosis and prevention are described.
Respiratory tests in diagnostics of renal diseases
Authors: Rapoport S. I. , Shubina Nona A.
Published: November 2020

C breath tests are the highly efficient noninvasive tools for estimation of liver condition. They provide a basis for the solution of many problems encountered in diagnostics and treatment of hepatic deseases including surgery, chemotherapy and transplantation.
Delayed coronary surgery for the treatment of acute myocardial infarction with elevated ST segment
Authors: Gazaryan George A. , Gazaryan G. G. , Evstratova S. G. , Grigor’yan K. S. , Chepkiy D. A. , Golikov A. P.
Published: November 2020

Aim: to develop algorithms of reperfusion therapy (RT) based on the assessment of the initial risk of death determining the priority use of delayed transdermal coronary surgery (TCS) unavailable in the early period. We compared effectiveness of different strategies for the treatment of 1245 patients with acute myocardial infarction (MI) and elevated ST segment in 2003-2007 including various TCS modalities at recommended time (n=88), delayed TCS within 24-72 hr after the onset of MI (n=194), thrombolytic therapy without subsequent TCS (n=275), and conservative therapy (N=688). The general and cardiovascular lethality was evaluated among 474 patients 5 years after discharge. The results suggest that unavailability of TCS in recommended time in case of enhanced risk of death does not exclude the possibility of its delayed application. TCS 24-72 hr after the onset of MI prevents complications and the fatal outcome the frequency of which remains high remains high not only in the early but also in the late post-infarction period. Delayed TCS can be effectively used to treat patients in case of their late admission or referral from other hospitals where X-ray endovascular methods for the treatment of acute MI are not used.
News in etiology and pathogenesis of irritated bowel syndrome
Authors: Sheptulin Arkadiy A. , Vze-Khripunova M. A.
Published: November 2020

The concept of irritated bowel syndrome as a complex of functional disorders that can not be explained by organic changes and are totally due to intestinal motility and visceral sensitivity needs revision. The development of this syndrome also depends on a number of pathogenetic and etiological factors, such as inflammation of intestinal mucosa, changes of its permeability, previous infection, altered microflora, gene polymorphism, and food hypersensitivity.
Characteristic of antibiotic-associated diarrhea in patients with acute cerebral circulation disorder
Authors: Shklyaev Aleksey E. , Gorbunov Yu. V. , Komissarova N. V.
Published: November 2020

This full-design study included patients admitted to the Regional Vascular Centre in 2013 and was aimed to obtain more detailed information on the need for medical aid, indications for antibacterial therapy, and the spectrum of the drugs being prescribed. 42 patients presented with antibiotic-associated diarrhea caused by Clostridium difficile. The composition of antibiotics used for mono- and combined therapy was analysed, details of the clinical picture are described, the importance of timely diagnostics and adequate treatment is emphasized.
Comprehensive diagnostics in patients with genotype 47, XXY Klinefelter syndrome
Authors: Akperova Gyunay A.
Published: November 2020

We undertook biochemical, hormonal, cytological analysis and sequencing CAG repetitions of androgen receptor gene in order to elucidate the cause of clinical polymorphism of Klinefelter syndrome. Elevated levels of LH (19.8 ± 4.2 E/l), FSH (22.7 ± 6.1 U/l), total cholesterol (6.8 ± 2.6 mmol/l), triglycerides (3.3 ± 1.0 mmol/l), and glucose (9.9 ± 3.8 mmol/l) suggested disturbances of lipid and carbohydrate metabolism. Two thirds of the patients had Klinfelter syndrome associated with mental retardation and psychic disorders. Patients with cleft palate and mental retardation and with psycho-social disorders had 45 and 43 CAG repetitions respectively, those without associations 38-40 repetitions. Increased frequency of CAG repetitions was directly proportional to the level of psychic development, social adaptation and professional activity but inversely proportional to the development of masculine sexual traits.
Effect of leptin on the gallbladder in patients with metabolic syndrome
Authors: Virstyuk Natalia G. , Senyutovich N. R.
Published: November 2020

The study involved 58 patients with chronic noncalculous cholecystitis (CNC) divided into two groups. Group I included 30 CNC patients with metabolic syndrome (MS), group II 28 CNC patients without MS. The control group consisted of 20 healthy people. MS was diagnosed according to International Diabetes Federation guidelines (2005). The following anthropometric parameters were determined: body mass index (BMI), waist to hip ratio, blood lipid profile (total cholesterol, triglycerides, high density lipoproteins (HDL), and low density lipoproteins (LDL)). Leptin and insulin levels were measured using commercial ELISA kits «Leptin ELISA» and «Insulin ELISA» (DRG International, Inc., USA) respectively. Insulin resistance index HOMA-IR (Homeostasis Model Assessment of Insulin Resistance) was calculated. It was shown that leptin level in CNC patients with MS was 2.61 times that in healthy subjects (p <0.001) and 2.47 times higher than in CNC patients without MS (p <0.001). Significant direct correlations between leptin blood levels andBMI, HOMA-IR index, triglycerides, and cholesterol were documented. The relationships between blood levels of leptin and the thickness of the gallbladder (GB) wall, the amount of cholesterol crystals in bile, and decreased bile release rate from GB which suggests effect of leptin on the structural and functional changes in GB.
The use of reamberin in combined intensive care of acute poisoning
Authors: Livanov G. A. , Lodyagin A. N. , Batotsyrenov Bair V. , Loladze A. T. , Glushkov S. I. , Kovalenko A. L.
Published: November 2020

This review is focused on the substrate antihypoxant reamberin used in intensive therapy of acute poisoning with special reference to the mechanisms of its action consisting in the reduction of the severity of metabolic disorders manifested as a decrease of tissue hypoxia, recovery of antioxidant defense and suppression of the activity of lipid peroxidation and endotoxicosis. The antihyhypoxant activity of reamberin is apparent as the reduction of the hypoxic brain lesions in patients with acute poisoning which leads to a significant improvement in the clinical course of acute poisoning and decreases the number of adverse outcomes.
ABO and RHD blood types distribution of the patients treated in the Federal Center of Cardiovascular Surgery of Krasnoyarsk
Authors: Makovskiy Aleksnder A. , Popov A. A. , Gysev S. D. , Barhatova L. I.
Published: November 2020

The knowledge of blood types frequency in hospital patients helps to plan and perform transfusion therapy at blood donor centers. The distribution of patients’ blood by ABO groups and RhD allows to more efficiently organize and use donor blood banks. The risk of a disease is related to genome composition and is inherited with an ABO blood type. Every person should know his (her) ABO blood type and RhD to enable early identification of the first symptoms of an illness. Materials and methods. This work is based on the study of 4831 blood samples from patients treated at the Center of Cardiovascular Surgery in 2013 (2885 (59,7%) men of the mean age 55 years and 1946 (40,3 %) women of the mean age 57 years). Results. Type A blood occurred most frequently (1787 or 37,0% samples) followed by group O (1625 or 33,6% samples). Samples of group B made up 1025 of the total (21,2%), AB blood group was found in 394 samples (8,2%). Conclusion. The blood types distribution of the ABO system in the patients treated at the Center of Cardiovascular Surgery was characterized by the following pattern: A > O > B > AB. Group A was identified in 37,0% of the patients. Its frequency is similar to that in the population of the western part of Russia and Moscow but different from that in the people living in nearby regions. The frequency of RhD system antigens is comparable in all regions of Russia. CcDEe, ccDEe, CcDee, CCDee are considered to be the most widespread phenotypes. The residents of the Krasnoyarsk region and some nearby regions having blood type A apply to the Center of Cardiovascular Surgery with cardiovascular disorders more frequently than those with others ABO blood types.
Pulmonary function in patients with type 2 diabetes and coronary artery disease
Authors: Bazdyrev Evgeniy D. , Polikutina O. M. , Kalichenko N. A. , Slepynina Yu. S. , Barbarash O. L.
Published: November 2020

Currently, there is no convincing evidence of respiratory failure in patients with diabetes mellitus (DM) and coronary artery disease (CAD). Aim: To evaluate the differences in the main parameters of pulmonary function in patients with isolated type 2 diabetes and diabetic patients with CAD. Materials and methods: Patients with diabetes were allocated to two groups depending to the presence of CAD. The assessment of carbohydrate and lipid metabolism, as well as the measurement of inflammatory markers were performed using standard methods of clinical and biochemical analysis. Respiratory function and diffusion capacity of the lungs (DLCO) were assessed using a body plethysmograph Elite Dl-220v. Results. Main pulmonary functional test parameters were within normal values, except residual volume in diabetic patients. Patients with concomitant CAD demonstrated lower values of the studied parameters compared to non-diabetic ones. A number of volume and flow rate parameters as well as DLCO correlated with systemic inflammation, decompensation of carbohydrate and lipid metabolism, and duration of diabetes. Conclusion. Diabetic patients with CAD suffered from respiratory failure, manifested as decline in pulmonary function and DLCO. Blood glucose levels, inflammation symptoms, dyslipidemia and myocardial dysfunction are among suspected causes contributing to the development and acceleration of this decline.
New anticoagulants in clinical practice. Effectiveness and problems
Authors: Bokarev Igor N. , Kondrat’eva T. B.
Published: November 2020

We analyze the effectiveness of new oral anticoagulants and antivitamins K for the treatment of patients with venous problems, atrial fibrillation, and acute coronary syndrome with reference to advantages of this therapy and methods of prevention of complications of these conditions.
Alterations of physiological rhythms in neurodegenerative disorders: problems and prospects of light therapy
Authors: Zueva Marina V. , Rapoport S. I. , Tsapenko I. V. , Bubeev Yu. A. , Manko O. M. , Smoleevsky A. E.
Published: November 2020

This review provides an outline of circadian disorders associated with neurodegenerative diseases of the brain in the elderly, including Alzheimer's (AD) and Parkinson's diseases (PD). Since light is one of the most powerful environmental cues synchronizing physiological rhythms, exposure to bright light is often used to treat sleep disorders, behavior of patients with severe dementia, gait, and other functions disordered in CNS pathologies. Photobiomodulation effects of the low-energy laser and LED radiation is also considered as a potential tool for the rehabilitation ofpatients with various pathologies. It yielded positive results in the treatment of both PD and AD. An external factor that can exacerbate a course of neurodegenerative diseases is light pollution. Irrational artificial lighting can cause jet lag, affect visual and cognitive functions. The review also summarizes the current understanding of fractal dynamics of physiological rhythms in healthy subjects (including brain activity) and their reduced complexity in pathological conditions. The loss of multiscale complexity of brain electrical activity has been documented for patients with AD, PD, epilepsy, and schizophrenia. It is thought to reflect fundamental changes in the regulation of the body's circadian rhythms. Recently, M.V Zueva proposed and theoretically substantiated the hypothesis that allows taking another look at the prospects for the use of light stimulation. It is expected that the use of stimuli with fractal structure can help to restore the retina and brain’s functions in neurodegenerative diseases by reactivation of neuronal plasticity and be an innovative method for the treatment of neurodegenerative disorders.
The relationship between serum and liquor IL-1β, IL-6, TNFa, IL-10 levels and clinical, cognitive and functional characteristics in acute ischemic stroke
Authors: Kulesh Aleksey A. , Kuklina E. M. , Shestakov V. V.
Published: November 2020

Introduction. Inflammation is probably the main process that links cardiovascular risk factors with damage to blood vessels and neurons. Elucidation of mechanisms of this relationship is an important issue. Materials and methods. 70 acute stroke patients were studied to assess their neuropsychological (MMSE, MoCA, FAB, Clock Drawing Test, Shulte Tables and Verbal Fluency) and functional status (mRS, RivermeadMobility Index). The serum and liquor IL-1β, IL-6, TNFa and IL-10 levels were analyzed. Control group included subjects without cerebrovascular diseases. Results. Stroke patients had higher IL-10 serum concentration than controls. No difference was found for other cytokines. There was correlation between serum and liquor cytokines levels. We found positive correlation between IL-1β, IL-6 and IL-10 levels. High IL-1β concentration was associated with vascular riskfactors, cardioembolic stroke, enhanced severity of cerebral stroke, low processing speed, impaired executive and visual-spatial functions and higher grade of mRS on discharge. The same pattern was revealed for IL-6 and IL-10. IL-6 level was related to mRS without relation to NIHSS on admission. High TNFa concentration was linked with vascular riskfactors, low MMSE score and processing speed. Discussion. Despite the antagonistic effects of IL-1β, IL-6 and IL-10 on inflammation, associations of these cytokines with anamnestic, clinical, neuropsychological and functional characteristics were similar in acute ischemic stroke. Probably, this fact indicates that during the acute ischemic brain damage process the immune response develops at the same time in pro- and anti-inflammatory directions. Its magnitude correlates with the damage severity and is associated with the effects of vascular riskfactors before stroke.
Pathogenesis of myocarditis in patients with bronchial asthma and pecilomycosis
Authors: Akhunov V. M. , Sizova Zh. M. , Akhunova Alima M. , Lavrent’eva T. P.
Published: November 2020

We studied the influence of activation ofpecilomycotic infection in blood on the morphofunctional state of myocardium based on the clinical and pathomorphological data. The study included 23 patients with bronchial asthma (BA) concomitant with pecilomycosis after acute viral respiratory infection; protocols of autopsies and pathological sections of the heart muscle of the patients who died from asphixy and acute cardiac insufficiency were analyzed. Histological sections showed up vascular dystonia of the microcirculation bed, arteriole spasms, wall destruction in small and medium-size vessels and the adjacent muscular tissue, stromal oedema, valvular swelling, andperiwall endocarditis. Cardiac cavities and coronary vessels contained erythrocyte-rich thrombi with ferulas of Paecilomyces at different stages of development. Clinical manifestations of destructive changes in the heart muscle developing under effect of Paecilomyces infection had the form of rhythm and conductivity disorders. The local protective inflammatory reaction of productive type had the form of intermediate and vascular-type myocarditis passing to postmyocarditic cardiosclerosis. Periodic bursts of activation ofpecilomycotic infection in blood with the accumulation of fungal phospholipase A2 and lipid metabolites produced membranotoxic effect and can play the key role in the development of atherosclerosis and hypertensive disease in patients with BA and pecilomycosis.
Hypertrophic
cardiomyopathy: forms and variants of the course, approaches to pharmacotherapy.
Authors: Kaplunova V. Yu. , Shakaryants Gayane A. , Kozhevnikova M. V. , Il’gisonis I. S. , Privalova E. V. , Belenkov Yu. N.
Published: November 2020

The problem of studying hypertrophic cardiomyopathy (HCM) continues to maintain its relevance, given the prevalence of the disease (1:500), and the risk of sudden cardiac death (SCD) in people of young working age. A matter of great interest are the issues of finding additional clinical, instrumental and genetic markers, environmental factors that can influence the formation of clinical variants of the course of hypertrophic cardiomyopathy, the risk of SCD and prognosis in HCM. We need a systematic approach to the formation of different forms and variants with HCM to develop tactics of treatment of patients and the formulation of risk factors for SCD.
The influence of deficit of endogenous neuropeptides on the clinical course of coronary heart disease
Authors: Dontsov Aleksandr V.
Published: November 2020

The study is aimed at elucidating the relationship between the blood b-endorphin level in patients with coronary heart disease (CHD) with metabolic syndrome (MS) and cardiovascular risk factors and evaluating the possibility to correct them by dalargin therapy. The study included 123 patients (61 men and 62 women) at the mean age 57.6±5,2 years randomized into 2 groups. The patients of group 1 (n=63) were given the standard treatment, those of group 2 (n=60) additionally received 2 mg/day of dalargin for 10 days (3 courses during 3 months). The group of comparison (n=84) contained 84 CHD patients without MS. Biochemical and immunological characteristics were measured by immunoenzyme and immunochemiluminescent assays before and 3 months after treatment. The study revealed inverse correlation between b-endorphin levels and those of leptin, insulin, cortisol, TNF-a, IL-6, oxidized LDLP, triglycerides (TG), and HDLP cholesterol. Standard therapy resulted in a 6.5% reduction ofinsulin level, 9,4% , 6,1%, and 17,4% reduction of TNF-a , IL-6, TG levels respectively; it increased the HDLP cholesterol level by 10,3% (p<0,05 for all values) but did not change other parameters of interest. Dalargin therapy caused a 32,6% and 17,4%, rise in the b-endorphin and HDLP cholesterol levels but decreased leptin, insulin, cortisol, TNF-a, IL-6, LDLP, and tG levels by 36,1%, 22,4%, 23,9%, 55%, 56,3%, 14% and 27,2% respectively (p<0,001). It is concluded that the decrease of the blood b-endorphin level in the patients with coronary heart disease and metabolic syndrome is associated with enhanced blood atherogenicity, hyperinsulinemia, hypercortisolemia, activation of pro-inflammatory cytokines and lipid peroxidation. Supplementation of conventional therapy with dalargin results in the increased b-endorphin level, enhanced anti-atherogenic effect, reduced activity ofpro-inflammatory cytokines and lipid peroxidation, reduction of leptin, insulin and cortisol levels.
Melatonin: the possibility to analyze the marker of age-related pathology in buccal epithelium and urine
Authors: Konovalov S. S. , Polyakova V. O. , Drobintseva A. O. , Kvetnoy I. M. , Kvetnaya T. V. , Lin’kova Natalya S.
Published: November 2020

Extrapineal and pineal melatonin is the marker of the aging rate of organism making it possible to characterize functional condition of the neuro-immuno-endocrine system. In this article we have used the new method for non-invasive diagnostics of melatonin expression in buccal epithelium and determination of the main melatonin metabolite 6-hydroxymelatonin sulfate (6-HMS) in urine of elderly people. Normal, impaired and enhanced melatonin expression was documented in 20.5%, 43.2% and 36.30% of the patients respectively. Such comprehensive melatonin and 6-COMT studies can be recommended for elderly patients with oncological, neurodegenerative, cardiovascular diseases, and ageing macular dystrophy. Moreover, melatonin expression analysis in buccal cells can be used for integral investigation of biorhythms in elderly people.
Typical errors in therapy of gastroesophageal reflux disease
Authors: Chikunova Marina V. , Khlynov I. B. , Khromtsova O. M.
Published: November 2020

Aim. To analyze compliance of doctors with the clinical guidelines for the management of patients with gastroesophageal reflux disease (GERD) under outpatient clinic conditions. Material and methods. An anonymous questionnaire study involving 104 general practitioners was undertaken. The questionnaires included items concerning lifestyle modifications, the use of proton pump inhibitors (PPI), dosage and time of their administration, combined therapy and endoscopic control. Results. The analysis of the filled questionnaires demonstrated that 15,6% of the doctors always discuss the necessity changing lifestyle with GERD patients, 75% of the doctors discuss it but occasionally, and 9,4% never hold such discussions. 56,7% of the doctors begin treatment from double doses of proton pump inhibitors regardless of the endoscopic stage of esophagus damage. The mode of PPI administration is at variance with that recommended by the instruction in 61,5% of the cases. The basic course of erosive esophagitis treatment lasts 4, 2, and 8 weeks in 45,2%, 9,6%, and 45,2% of the cases. Treatment of GERD starts from combined therapy in 14,4% of the cases. Monotherapy with PPI is inefficient in 85,6% of the cases. Endoscopic control of erosive esophagitis is practiced by 51,9% of the doctors, 48,1% of the respondents recommend this diagnostic procedure only in the absence of clinical effect. Conclusion. Our analysis revealed typical mistakes in the treatment of patients with GERD, demonstrated the importance of expert control and support of training physicians, and introduction of modern quality standards into the practical management of patients with this pathology.
Characteristics of bone mineral density in elderly patients with diabetes
mellitus
Authors: Sergeeva V. V. , Dymnova S. E. , Bobylev V. A.
Published: November 2020

Diabetes mellitus is a most important medical and social problem in Russia. Osteoarthropathy, osteopenia and osteoporosis are chronic complications of diabetes. There is no consensus on the pathogenetic mechanisms of development of changes of the bone tissue in this pathology. The present literature review outlines the problem.