bluuebunny/crossref_metadata_2025 huggingface dataset:
Tú di rana y yo salto, una propuesta analítica desde la derivación delocutiva
Authors: García Ávila Aldo
Published: January 2025

Las bases para el desarrollo de una teoría de la enunciación tienen como antecedente, a su vez, las teorías en torno a la noción de discurso, que tienen sus orígenes en el logos de la filosofía clásica, donde logos se refiere a la práctica lingüística como un proceso discursivo. El objetivo del presente trabajo consiste en describir las marcas que la enunciación deja en el enunciado, a través de un ejemplo de expresión formularia, Tú di rana y yo salto, en el marco de la teoría de la derivación delocutiva, bajo el modelo de delocutividad generalizada, propuesto por Jean-Claude Anscombre.
motivo de la consciencia trágica en “Los heraldos negros” de César Vallejo
Authors: Vallejo López Sam
Published: January 2025

En este ensayo se presenta un análisis del motivo de la consciencia trágica dentro del poema “Los heraldos negros” de César Vallejo. En él se tendrá por objetivo demostrar la presencia de este motivo dentro de la obra, para lo cual se implementó el concepto de consciencia de lo trágico expuesta por Crescenciano Grave, introduciéndola mediante el concepto del motivo literario, tomado de las ideas de Cesare Segre y Mercedes Orea. Se considera que Vallejo, al ser consciente de su tragedia, debido a acontecimientos fuertes que marcaron su vida, recurrió a ella como un medio de producción literaria, siendo este motivo introducido mediante recursos retóricos que, se tiene la hipótesis, fueron planteados de tal manera que el lector pudiera apropiarlos a sus propias tragedias, otorgándole un vínculo con el poema, mediante el cual pusiera su propia consciencia trágica.
Tras las puertas del Paraíso: Una (re)visión de Ana Clavel
Authors: R. Santeliz Arturo
Published: January 2025

El juego del erotismo en el cual nos adentra Ana Clavel en Las ninfas a veces sonríen, tiene dos caras. En la primera se despliega el viaje hacia el autodescubrimiento, hacia la búsqueda de aquello que mueven nuestras pasiones; en segundo lugar, hay una reafirmación del yo, un posicionamiento en el mundo. A través de su novela, la autora desafía estereotipos y realiza un tratado sobre el deseo y el erotismo, en el cual se explora la naturaleza humana y se repiensa sobre los roles que suelen marcar estos temas.
The Relationship Between Workload, Locus of Control, and Self Efficacy with Performance: A Study on Employees at PT Petrokopindo Cipta Selaras Factory
Authors: Fadilah Maulana Azhar , Firdaus Vera
Published: January 2025

This study aims to determine and analyze the partial and simultaneous effects of workload, locus of control, and self-efficacy on employee performance at PT Petrokopindo Cipta Selaras, Sidoarjo. The type of research used is explanatory research with a population of 100 employees. The sampling technique applied is total sampling, so that the number of respondents reaches 100 people. Data analysis was carried out using multiple regression, including the t test and F test. The results showed that all variables had a significant effect on employee performance. Workload has a positive effect, especially when the tasks assigned are in accordance with the capabilities of employees, and can even have a positive impact if they exceed capacity. Locus of control plays an important role, where employees who are able to control themselves and think positively tend to be more successful in completing tasks. Self-efficacy is also shown to have a significant influence, with employees who have high self-confidence being able to solve the problems and tasks given. Overall, this study concludes that encouraging clear work goals, as well as providing adequate support and resources, will create a comfortable work environment and can improve employee performance.
LSTM-Based NLP Approach for Spelling Error Detection and Correction in Scientific Writing Indonesian Language
Authors: Halim Yeru Dwi Pratama , Nurhaida Ida
Published: January 2025

Scientific writing requires precision and clarity to uphold credibility and effective communication. Errors such as spelling mistakes and typos can compromise the quality and reliability of scientific texts. This study proposes a Long Short-Term Memory (LSTM)-based approach to detect and correct spelling errors, enhancing text accuracy and readability. The dataset comprises 45,698 standard words, supplemented with typo variations to improve model performance. Data is sourced from the Indonesian Dictionary (KBBI) and undergoes normalization and preprocessing to capture diverse error patterns. The model’s performance is evaluated using a confusion matrix, achieving 93% accuracy and high precision, recall, and F1-score metrics. These results demonstrate that the proposed NLP-based LSTM model offers an effective and reliable solution for identifying and correcting spelling errors. This approach significantly enhances the quality of scientific writing, ensuring more transparent and credible communication.
Training and Guidance on the Preparation of Islamic Value Based Lesson Plans and Writing Classroom Action Research for Mathematics Teachers at Lhokseumawe Vocational High School
Authors: Setiawan Setiawan , Yusnaini Yusnaini
Published: January 2025

Activities carried out in community service for Lhokseumawe City Vocational School mathematics teachers are Classroom Action Research (CAR) writing activities and designing lesson plans based on Dinul Islam. The aim of this activity is for Lhokseumawe City Vocational School mathematics teachers to be able to create CAR and design lesson plans based on Dinul Islam on an ongoing basis in order to improve teacher careers. The form of this activity is to carry out training and mentoring for 4 days from 26 to 29 April 2021 with a total time of 32 JP with an allocation of 2 days of training and mentoring for CAR writing and 2 days for designing Dinul Islam-based lesson plans. This is then continued with assistance in the form of guidance in writing CAR and lesson plans based on Dinul Islam from May to June 2021. The work system carried out by teachers is group in nature and they work together in determining the CAR title and writing CAR. Meanwhile, the work system in designing Dinul Islam-based RPPs is individual. The results obtained resulted in 10 CAR titles with continuous writing, while Dinul Islam-based lesson plans were printed and 26 lesson plans were collected from 30 participants.
Mimetic Analysis of “Black Sun” in the Korean Drama “Taxi Driver 2” With the Burning Sun Case
Authors: Khairunnisa Siti , Ginting Reza Pahlevi
Published: January 2025

This study explores the relationship between the real-life Burning Sun scandal and its fictionalized portrayal in the Korean drama “Taxi Driver 2”, specifically focusing on the episode titled "Black Sun." Using the mimetic approach, the research investigates how the drama mirrors real societal issues, including violence, police collusion, celebrity involvement, sexual harassment, and drug use. The Burning Sun scandal, which involved a nightclub in Gangnam, South Korea, became notorious for its links to organized crime, drugs, sexual abuse, and the corruption of law enforcement. The study analyzes key scenes from “Taxi Driver 2”, drawing comparisons between the drama's depiction of the events and the actual incidents that occurred, such as drug use, police inaction, and violent assaults. By examining the dialogue and plot structure in the drama, the research highlights how “Taxi Driver 2” critiques the dark realities of the entertainment industry, particularly the exploitation and abuse within the nightlife scene. Additionally, the study explores the role of K-pop idols in the scandal, which is reflected in the characters portrayed in the drama. This research contributes to the understanding of how real-life events are translated into visual narratives, offering insights into the power of media in shaping public perception and raising awareness about social issues. The findings indicate that “Taxi Driver 2” successfully employs a mimetic approach to replicate key elements of the Burning Sun case, thereby providing a lens through which viewers can critically engage with the ongoing social problems illustrated by the scandal. This research fills a gap in the existing literature by bridging the connection between media representations and real-life societal phenomena, offering a novel perspective on the role of Korean dramas in reflecting social realities.
The Concept of Critical Thinking in the Quran: A Study of the Story of Qabil and Habil in Tafsir Al-Misbah
Authors: Setiawan Setiawan , Ibrahim Muhammad Syahrial Razali
Published: January 2025

The Qabil and Habil incidents are the first murder events that have happened to humans that have been told in the Quran, but nevertheless there are many life lessons that can be learned from these events. This study aims to describe the analysis of the study of the interpretation of Al-Misbah Surah Al-Maidah verses 27-31. The research method uses a qualitative approach with text analysis. The results of the study, which is a study of the tafsir of Al-Misbah by Quraish Shihab, show that the events of Qabil and Habil are full of dialogue between the two humans. Based on the dialogue, it can be concluded that: 1) The ability to think critically is able to analyze the information obtained from observation and produce a decision in solving problems. 2) Critical thinking skills can affect the emotional intelligence of oneself and others, 3) Critical thinking skills can evaluate all more objective information, 4) Critical thinking skills are able to assess, critically and develop more logical ideas. However, one of the factors that hinders a person from thinking critically is the instability of emotional control.
Evaluation of the implementation of quality management system to improve school accreditation in academic transformation
Authors: Prabowo Galuh , Aimah Siti , Algifari Muhammad Fikri , Fayoumi Ziyad El
Published: January 2025

This study aims to evaluate in depth the implementation of the quality management system in an effort to improve school accreditation while encouraging academic transformation. to what extent the implemented quality management system has been effective in optimizing the quality of education in the madrasah, especially in meeting higher national accreditation standards. This research used a qualitative approach with a case study method to evaluate the implementation of the quality management system in improving accreditation and academic transformation. Data were collected through in-depth interviews, participatory observation and documentation study. In-depth interviews provided insights into stakeholders' experiences, while observations enabled understanding of hands-on processes. Documentation helped analyze important documents, such as accreditation reports and strategic planning. Through a combination of these techniques, this study produced comprehensive findings for recommendations on improving the quality management system in schools. The results of this study show that the implementation of the Quality Management System at MA Al-Amiriyyah Banyuwangi still faces significant challenges. Firstly, although the policy is in place, its implementation has not been consistent, especially in assessment and evaluation. Secondly, stakeholder involvement is still limited, so more intense collaboration between internal and external parties is needed. Finally, the utilization of evaluation data to improve the quality of education is not yet optimal. To achieve higher accreditation and better academic transformation, it is necessary to improve the consistent implementation of the Quality Management System, wider stakeholder involvement, and more systematic utilization of evaluation data.
Toxicity Test of the Combination of N-Hexane Extract of Black Pepper (Piper nigrum L.) and Yogurt on the Digestive Organs of Mice (Mus musculus)
Authors: Inayah Nurul , Mutiati Enni , Sa’diyah Halimatus
Published: January 2025

Black pepper (Piper nigrum L) is a spice that is widely used in cooking by people in Indonesia, earning the nickname "King of Spice". The chemical content in Black Pepper (Piper nigrum L) is piperine. Piperine can activate Transient Receptor Potential Vanilloid Type 1 (TRPV1), causing heartburn, heat and increased stomach acid. Therefore, researchers combined black pepper (Piper ningrum L.) with yogurt, because it is known that yogurt can suppress stomach acid and the growth of bad bacteria in the intestines. The aim of this research was to determine the potential toxicity of the combination of black pepper extract (Piper ningrum L.) and yogurt on the digestive organs and the duration of death of mice (Mus musculus). In research that has been carried out using RAL with 5 treatments and 4 replications. The samples used were female mice (Mus musculus). Next, descriptive analysis was carried out. The results of the research that has been carried out show that the concentration of 25 mg/kg bw in the combination of Black Pepper (Piper ningrum L.) extract and yogurt on the anatomy of the stomach and intestines is closer to the positive control (P1) and the combination of Black Pepper (Piper ningrum L.) extract and yogurt with a concentration of 75 mg/kg bw on stomach and intestinal anatomy was closer to the negative control (P0).
An Expressive Analysis of Tulus' Song "Gajah" Lyrics Using a Pragmatic Framework
Authors: Ginting Reza Pahlevi , Azis Abdul , Ginting Mutia Suri
Published: January 2025

This study analyzes the linguistic and emotional layers of Tulus' song “Gajah”, focusing on speech acts and implicature in the lyrics and their connection to themes of self-acceptance, social stigma, and identity transformation. Utilizing a qualitative descriptive approach, the research combines expressive and pragmatic critique methodologies to explore how the lyrics communicate personal experiences and emotions. The primary data consists of the song's lyrics and supplementary interviews, articles, and reviews about the song’s creation. By employing documentation, observation, and textual analysis, the study examines various speech acts—representative, directive, expressive, declarative, and commissive- and contextual meanings. The analysis shows that Tulus effectively uses language to convey personal and societal experiences, mainly focusing on how childhood ridicule based on his physical appearance evolves into a message of empowerment and acceptance. Furthermore, the study uncovers implicit meanings (implicature) embedded in the lyrics, illustrating the shift of social stigma into a symbol of strength and pride. The findings suggest that Tulus' lyrics represent a personal journey toward self-acceptance and address broader societal issues, urging listeners to reinterpret mockery as a form of hidden praise. By integrating speech act theory and pragmatic implicature analysis, this study demonstrates how “Gajah” is a powerful vehicle for emotional expression and social critique, ultimately conveying a message of solidarity and personal transformation.
Affective Factors in Numeracy: Exploring How Math Anxiety and Self-Efficacy Influence Numeracy Skills
Authors: Nuraini Ni Luh Sakinah , Permata Santy Dinar , Cholifah Puri Selfi , Aurelia Davina , Nafisah Nada , Afifah Rifdah
Published: January 2025

This study investigates the relationships between math anxiety, self-efficacy, and numeracy skills among prospective primary school teachers at the State University of Malang. Through quantitative methods, data were gathered from 130 participants using structured questionnaires and numeracy tests. Descriptive statistics and correlation analyses were performed to assess the extent to which math anxiety and self-efficacy influence numeracy performance. The findings reveal weak yet statistically significant correlations, with math anxiety negatively affecting numeracy skills and self-efficacy showing a positive association. However, these variables together accounted for only 3.5% of the variance in numeracy performance, leaving 96.5% of potential predictors unexamined. This suggests that psychological factors like math anxiety and self-efficacy, while important, play a less direct role in shaping numeracy skills than traditionally assumed. The results underline the need for a broader and more integrative approach to understanding the multifaceted nature of mathematical competence. Future studies are encouraged to investigate additional contributing factors, such as cognitive and environmental influences, and to expand the sample size for broader generalization. These findings have implications for designing interventions that simultaneously address psychological and contextual elements to enhance numeracy skills among prospective educators.
The Politicization of Aid in the Electoral Process in Banda Aceh
Authors: Fajri Nurul , Susilawati Novi , Helmi Helmi , Fajri Raihal
Published: January 2025

This study examines the politicization of aid in the 2024 Legislative Election in Banda Aceh through the lens of patron-client theory, exploring how candidates or political parties use material aid to secure electoral support. Using a qualitative descriptive method, data were collected through interviews with voters in Banda Aceh and a review of relevant literature. The findings reveal that material aid often functions as a transactional tool, with voters expected to reciprocate by voting for the candidates providing assistance. This reciprocal expectation significantly influences voter behavior, as many prioritize immediate material benefits over ideological or programmatic considerations. However, not all voters adhere to this transactional dynamic; some evaluate candidates based on their political qualities and programs, regardless of aid. Perceptions of candidates who abstain from providing aid vary—some voters see the absence of aid as a disadvantage, while others value the candidates' vision and integrity over material offerings. The study concludes that while aid politicization impacts electoral outcomes, maintaining voter trust and loyalty depends on candidates' fulfillment of political promises and long-term commitment. Balancing short-term aid strategies with genuine political accountability is essential for sustaining trust and upholding the integrity of the political system.
Analysis of the Effectiveness of the Independent Curriculum in Increasing Learning Independence: A Comparative Study Between High School and Basic Education Levels
Authors: Noho Mubin , Adam Adiyana , Usia Rakiba , Yoioga Tamsin , Bambang Sumarni , Masuku Mardia
Published: January 2025

This research analyzes the effectiveness of the Merdeka Curriculum in improving students' learning independence at high school and elementary school levels, with case studies at MAN 1 Ternate and MIN 1 Ternate. Using a qualitative approach, the research collected data through in-depth interviews, observations, documentation, and focus group discussions. The results showed significant differences in the level of learning independence between the two educational levels. High school students achieved an average learning independence score of 78.5%, while elementary students reached 62.7%. These differences were influenced by cognitive development factors, teacher readiness, and external support. High school students demonstrated better ability in planning learning, conducting independent learning, and evaluating learning outcomes. Meanwhile, elementary students required more intensive guidance but showed high enthusiasm in project-based learning. The research concludes that the implementation of the Merdeka Curriculum needs to be adapted to students' developmental characteristics at each educational level, emphasizing increased teacher readiness, especially at the elementary level, to maximize curriculum effectiveness in improving learning independence.
Education Financing Management Strategy in Improving Facilities and Infrastructure at SMP Nu Al Islami Pesanggaran
Authors: Sharifudin Khabib , Ekaningsih Lely Ana Ferawati
Published: January 2025

This study aims to formulate an effective and efficient education financing management strategy in improving the quality of facilities and infrastructure at SMP NU Al Islami Pesanggaran. With a qualitative approach and descriptive design, this study explores the social, cultural, and economic conditions of schools through in-depth interviews, participatory observations, and documentation studies. The data were analyzed using the thematic analysis method with triangulation to ensure the credibility of the results. Research at SMP NU Al Islami Pesanggaran highlights three important aspects in education management 1. The strategic role of the school committee as a mediator to increase community participation. 2. Suboptimal financial management due to lack of planning and technology. 3. As well as partnerships with external parties that have not been utilized to the fullest. Strengthening communication and management capacity is needed to optimize the role of school committees. Financial management solutions include training and implementation of modern systems. External partnerships can be strengthened with better communication strategies.
Implementation of the Kulliyatul Mu'allimin Al-Islamiyah (KMI) Curriculum in the Development of Noble Morals Students at Khaira Ummah Islamic Boarding School Southeast Aceh
Authors: Hidayat Farhan , Asari Hasan , Dahlan Zaini
Published: January 2025

National character building has been a priority for Indonesia since 1945 and is integrated into national development. National education plays an important role in shaping a generation that is faithful, pious, and has noble character. However, globalization and the information revolution present major challenges, including the influence of foreign cultures that can shift local values. Islamic boarding schools, as traditional Islamic educational institutions, are required to adapt in order to maintain their relevance in shaping national character in the modern era. Therefore, innovation and transformation are needed in the Islamic boarding school education system to prepare students to face the modern world while maintaining noble values. Khaira Ummah Islamic Boarding School, as a modern Islamic educational institution, adopts the learning system from the Modern Darussalam Gontor Islamic Boarding School, including the KMI (Kulliyatul Mu'allimin Al-Islamiyah) Curriculum. This approach combines traditional values with modern educational methods to create a conducive learning environment for the formation of character and intellectualism of students. This study aims to describe and analyze the planning, implementation, and evaluation of the KMI curriculum in fostering noble character of students at Khaira Ummah Islamic Boarding School . In this study, the researcher used a qualitative approach with a case study research type. Data collection was obtained through observation, interviews, and documentation. Data analysis techniques include data collection, data reduction, data presentation, and drawing conclusions, while checking the validity of the data was carried out by extending participation, observation accuracy, triangulation. The results of the study indicate that the implementation of the KMI curriculum in the process of fostering noble morals of students at the Khaira Ummah Islamic Boarding School has been running well and has achieved a number of significant advances. Although there is room for improvement, especially in terms of facilities and infrastructure, curriculum development, improving the quality of human resources, more effective supervision, and a more comprehensive evaluation process, the steps that have been taken show a strong commitment to improving the quality of fostering morals of students. Although there are still challenges faced, the efforts made to achieve the goal of fostering noble morals have shown encouraging results and have the potential to achieve more optimal results. The difficulties faced are seen as opportunities to continue learning and developing, as well as important steps in the process of continuous improvement that will bring the Khaira Ummah Islamic Boarding School to a higher level of success in fostering the noble morals of its students.
Propiedades fisicoquímicas y sensoriales de la infusión de remolacha (Beta Vulgaris L.)
Authors: Farías Campomanes Angela , Alfonso Yina , Galindo Jorge , Jiménez Yineth , Medina Camila , Ramírez Saday
Published: January 2025

Beetroot (Beta vulgaris L.) is a product appreciated for its versatility of uses and organoleptic characteristics, as well as for its anti-inflammatory properties and for preventing chronic diseases. However, the alternatives of products with added value derived from beets are still scarce. This work aimed to determine the physicochemical and sensory properties of beetroot tea. For this purpose, analyses of acidity, total soluble solids, ashes, density, moisture, unsaturations, carbonyl groups, phenols, tannins, triterpenes, sterols, flavonoids, carbohydrates, coumarins, and lactones were carried out to tea and extract of beetroot. Later, the sensory analysis (color, odor, taste, and texture) was carried out in three beetroot tea formulations (60, 70, and 80% of dehydrated beetroot). The sensory analysis results were analyzed using the ANOVA test. Physicochemical characterization shows that beetroot has good physical and chemical properties to prepare beetroot tea. Likewise, phenols, tannins, flavonoids, and carbohydrates were present in beetroot extract and infusion. The ANOVA of sensory analysis results showed no significant difference (p-value>0.05) between the color, odor, taste, and texture of the samples. However, it is suggested that beetroot tea formulated with 70% dehydrated beetroot presents the best balance between sensory characteristics and nutritional contribution.
Pengaruh Pendekatan Science Environment Technology and Society pada Materi Pencemaran Lingkungan terhadap Kemampuan Literasi Sains Siswa
Authors: Rabadia Hufila Ode , Lessy Djaffar , Mursalin Enggal
Published: January 2025

Penelitian ini dilakukan untuk mengetahui pengaruh pendekatan Science Environment Technology and Society pada Materi Pencemaran Lingkungan terhadap Kemampuan Literasi Sains Siswa Kelas VII di MTs Nurul Huda Limboro. Penelitian ini menggunakan metode quasi eksperiment dengan desain penelitian nonequivalent control group design. Seluruh siswa kelas VII terlibat sebagai populasi dan sampel diambil dengan menggunakan purposive random sampling dimana kelas VII A sebagai kelas eksperimen dan kelas VII B sebagai kelas kontrol. Pengumpulan data dilakukan dengan menggunakan soal tes kemampuan literasi sains. Teknik pengolahan data melalui uji normalitas, homogenitas, dan uji independent samples t-test dengan bantuan SPSS Statistic 27. Hasil data posttest dengan menggunakan software SPSS Statistic 27 memperoleh nilai signifikansi uji independent samples t-test yaitu sebesar 0,000 < (α) 0,05 yang artinya H0 ditolak dan H1 diterima, ini menunjukkan bahwa penggunaan pendekatan Science Environment Technology and Society berpengaruh dalam meningkatkan kemampuan literasi sains siswa.
Playing Politics? A Meta-Analysis on Active Learning in Political Science Classrooms
Authors: Dunlop Emily , Way Christopher
Published: January 2025

Active learning (AL) has gained traction in political science education, often touted as an evidence-based alternative to traditional lecture methods. Despite its widespread adoption and the establishment of numerous AL initiatives across the US, the empirical evidence supporting AL’s effectiveness in political science remains limited. While over 300 articles on AL have been published in political science journals since 2010, the majority of robust evidence comes from STEM fields. This paper aims to critically evaluate the existing evidence for AL effectiveness in political science. We outline a meta-analysis of ALPS, using a robust design and checks on internal validity of the studies under review. We also propose unpacking ALPS practices, recognizing that specific AL techniques, such as role-play and simulation, may have varying impacts. Ultimately, we call for higher-quality studies and a shift from questioning whether AL works to exploring which AL practices are most effective.
Pendampingan Pemanfaatan Digitalisasi Augmented Reality Sebagai Media Pembelajaran Interaktif Pada SDN Wonorejo 1 Kab Blitar
Authors: Rahmat Mohammad Faried , Romadhona Rizki Dwi , Meyshita Nabillah Rachelia
Published: January 2025

Technological developments in the field of interactive learning media have now experienced significant progress. The development of this technology does not only facilitate the delivery of one-way information. But it provides opportunities for educators and students to explore learning more interactive and interesting. One of the latest learning media technologies is Augmented Reality. This technology offers the merging of the physical world and virtual elements that are attractive to users. The method in this study uses applied research. for this application development method using the MDLC method or Multimedia Development Life Cycle. For testing in this study is divided into two namely testing based on application functions using the blackbox method and testing using a questionnaire as an evaluation of the use of AR as a determination of conclusions. Based on the results of blackbox testing, a number of 100% is obtained which indicates that this application does not experience problems in using the functions of the features offered. For the results of questionnaire testing obtained an increase in student motivation by 70% which has a high motivation to learn Augmented Reality-based learning. Based on these tests it can be concluded that Augmented Reality Technology and Quizzes can increase student learning motivation.
HDAC10 and its implications in Sézary syndrome pathogenesis
Authors: Pieniawska Monika , Rassek Karolina , Skwara Bogumiła , Żurawek Magdalena , Ziółkowska-Suchanek Iwona , Visser Lydia , Lodewijk Monique , Sokołowska-Wojdyło Małgorzata , Olszewska Berenika , Nowicki Roman J. , Stein Tomasz , Dańczak-Pazdrowska Aleksandra , Polańska Adriana , Szymoniak-Lipska Marta , Rozwadowska Natalia , Iżykowska Katarzyna
Published: January 2025

Cutaneous T-cell lymphomas (CTCL) are a group of rare hematological malignancies characterized by infiltration of malignant T-cells into the skin. Two main types of CTCL constitute of Mycosis Fungoides (MF), a more indolent form of the disease, and Sézary syndrome (SS), the aggressive and leukemic variant with blood involvement. Sézary syndrome presents a significant clinical challenge due to its very aggressive nature, poor prognosis, and treatment resistance, and to date, the disease remains incurable. Histone deacetylase inhibitors have gained attention in CTCL treatment with promising results, but they expose limited specificity and strong side effects. Recent genomic studies underscore the role of epigenetic modifiers in CTCL pathogenesis, prompting an investigation into HDAC10, a member of class IIb HDACs, in SS. HDAC10 was investigated in different cancers, revealing its involvement in cell cycle regulation, apoptosis, and autophagy, but its role in CTCL is unknown. In this study we aimed to determine the role of HDAC10 in SS, focusing on its cellular localization, role in cell growth, and therapeutic potential. We indicated that HDAC10 is overexpressed in SS patients and located mainly in the cytoplasm. Its overexpression leads to an inhibitory effect on apoptosis progression when exposed to the pro-apoptotic compound Camptothecin (CPT). Knockdown of HDAC10 resulted in reduced cell growth and induction of apoptosis and autophagy, highlighting its potential importance in CTCL pathogenesis. Whole transcriptome analysis indicated that HDAC10 is associated with crucial cancer-related pathways, for example, hematopoietic cell lineage, PI3K-Akt signaling pathway, Ras signaling pathway, MAPK signaling pathway or JAK-STAT signaling pathway, which are critical for the survival and proliferation of malignant T cells. Inhibition of HDAC10 with selective HDAC10i increased the sensitivity of Sézary cells to the pro-apoptotic CPT. Our findings demonstrate that HDAC10 plays a key role in the molecular background of Sézary syndrome, highlighting its importance in the cellular mechanisms of the disease.
Environmental journalism from Brazil: trajectory and challenges for research
Authors: Beling Loose Eloisa
Published: January 2025

This article, based on a literature review and documentary research, retraces the trajectory outlined by environmental journalism research in the Brazilian context. It does so by discussing the development of the field in other countries, especially those in the Global North, where most of the research and publications are largely concentrated. It also presents epistemological aspects of Latin American communication and the critique of environmental coloniality, present in the constitution of what can be called the ecological literacy of journalists covering the subject.
The roles of teachers’ beliefs and instructional practices in students’ mathematical mindset
Authors: Piyakun Araya , Phusee-Orn Songsak
Published: January 2025

Introduction

Mathematics education development is an urgent topic, with an emphasis on increasing students’ motivation to learn mathematics.

Methods

This study aimed to investigate the impacts of teachers’ mathematical mindset, task values, and instructional practices on students’ mathematical mindset, using students’ perceived instructional practices as a mediator. The participants consisted of 96 teachers and 936 secondary school students. The research instruments included a mathematical mindset scale for teachers and students, a task value scale for teachers, an instructional practice scale for teachers, and a perceived instructional practice scale for students. The statistics for analyzing data included mean, standard deviation, and Structural Equation Modeling (SEM).

Results

The finding revealed that, from most to least, the variables that mutually influenced students’ mathematical growth mindset were students’ perceived instructional practices, teachers’ instructional practices, teachers’ values, and teachers’ mathematical growth mindset.

Discussion

The study’s findings can serve as a framework for developing teachers, who are essential to mathematics education and enhancing secondary school students’ motivation for mathematical learning.
Correlation between liver fibrosis in non-alcoholic fatty liver disease and insulin resistance indicators: a cross-sectional study from NHANES 2017–2020
Authors: Yang Bo , Gong Mingsu , Zhu Xiaojie , Luo Yang , Li Ruiqiu , Meng Hai , Wang Yuhan
Published: January 2025

Introduction

Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease worldwide, with liver fibrosis (LF) being a crucial pathological feature in the progression of NAFLD. Insulin resistance (IR) is believed to play an important role in the pathogenesis of NAFLD and the development of LF. This study aims to explore the relationship between various IR indicators and LF in patients with NAFLD.

Methods

This study utilized data from the National Health and Nutrition Examination Survey 2017-2020 cycles. Liver steatosis and fibrosis were assessed using liver ultrasound transient elastography. To assess the association between multiple IR indicators and LF, the study methodology included univariate and multivariate logistic regression, as well as restricted cubic spline (RCS) analysis. Subsequently, we used multivariate logistic regression to develop and validate a predictive model for LF, and evaluated the model’s performance using the area under the curve (AUC) and calibration curve.

Results

A total of 904 patients were included in the final analysis. Among these NAFLD patients, 153 (16.92%) had LF. Compared to non-LF patients, LF patients had significantly higher body mass index (BMI), waist circumference (WC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), HbA1c, and fasting blood glucose (FBG) levels (all p < 0.05). Analysis of IR indicators showed that LF patients had significantly higher levels of TyG, TyG-WHtR, TyG-BMI, TyG-WC, TyG-GGT, METS-IR, and HOMA-IR (all p < 0.05). After adjusting for covariates, TyG-WHtR remained an independent risk factor (OR=2.69; 95% CI: 2.08-3.47), indicating a strong correlation with LF. The developed nomogram, incorporating AST, TyG, TyG-BMI, and diabetes, showed an AUC of 0.809 (95% CI: 0.771-0.847), indicating good predictive performance for LF in NAFLD patients.

Conclusions

This study confirms that a significant association between various IR and LF in NAFLD patients, and the developed nomogram provides a practical tool for early risk assessment. These findings underscore the clinical value of incorporating IR indices into routine practice to identify high-risk patients, enabling timely interventions to prevent fibrosis progression and improve outcomes.
Spatiotemporal patterns and driving factors of NDVI changes in the central and Western Asia economic corridor over the past decade
Authors: Wang Kaimin , Xu Min , Wang Shaohua , Wang Lin , Tian Haijing , Boonprong Sornkitja , Gao Xiaotong , Yang Xinwei , Guo Heyi , Li Jingbo , Yang Yujie , Hu Ruichen , Zhang Yu , Cao Chunxiang
Published: January 2025

The Central and West Asia Economic Corridor (CWAEC) is a critical component of the Belt and Road Initiative (BRI), and that vegetation changes in the region are under significant uncertainty due to fragile ecological conditions, diverse climatic variability, and that these uncertainties are compounded by the interaction of natural factors and human activities. For the sustainable development of the CWAEC, it is urgent to pay attention to its regional environmental health. Using MOD13A3 NDVI data and ERA5 meteorological reanalysis data, this study evaluated the spatiotemporal changes in NDVI across the CWAEC over the past decade of BRI implementation. A trend analysis method was applied to assess NDVI development, and the relative impacts of climate change and human activities were explored through a multivariate regression residual analysis. The results revealed a declining trend in NDVI across the CWAEC, with an average rate of −0.26 × 10⁻2 a⁻1, and 50.74% of the region exhibiting insignificant degradation. Significant degradation was observed in the hilly areas of northern Kazakhstan, the low-altitude areas bordering the Tian Shan and Hindu Kush mountains, and the central part of the corridor. Conversely, significant restoration was concentrated in the hinterland of Kazakhstan and the coastal areas of the Caspian Sea. Climate change inhibited NDVI changes in 65.24% of the region, while human activities facilitated changes in 49.64%, indicating that the variations in NDVI were primarily driven by the combined effects of these factors. This study identifies the key drivers of NDVI changes in the CWAEC since the implementation of the BRI, provides scientific evidence to support the sustainable development of green BRI initiatives, and offers valuable insights for future ecological restoration and engineering projects within the corridor.
Vegetation greening and climate change respectively regulates the long-term trend and interannual variability in evapotranspiration over the Loess Plateau since the 21st century
Authors: Tan Qiaoyin , Hua Ting , Zhao Haichen , Zhou Peiye
Published: January 2025

Since the 21st century, large-scale afforestation projects on the Loess Plateau have resulted in significant vegetation greening, contributing to ecosystem restoration and enhanced soil conservation. However, these efforts have also led to soil aridification, declining groundwater levels, and reduced terrestrial water storage. These negative consequences are primarily attributed to increases in evapotranspiration (ET), which has augmented water consumption. Despite these findings, the underlying mechanisms driving ET variations remain contentious due to the complex interplay of multiple factors. In this study, we employed a logical attribution method, which attributes vegetation changes predominantly to anthropogenic activities (e.g., reforestation or land-use changes), while directly linking changes in climatic factors (e.g., temperature and precipitation) to climate change. We separately examined the contributions of long-term trends and interannual variability in ET to reveal distinct driving forces. Between 2000 and 2022, approximately 80% of areas showing significant changes in ET and its components were directly influenced by vegetation greening, particularly in the central part of the Loess Plateau, where restoration efforts were most prominent. In contrast, only around 20% of these changes were attributable to climate change and other factors. After removing long-term trends, interannual variations in ET were found to be more closely associated with climatic factors (temperature and precipitation), especially in arid and semi-arid regions. This indicates that climate is the dominant factor driving interannual variations in ET across the Loess Plateau. Our findings contribute to a deeper understanding of the water cycle dynamics in the context of large-scale vegetation restoration on the Loess Plateau. These insights provide a scientific foundation for policymakers to evaluate the environmental impacts and potential water-related risks associated with ecological restoration projects.
Based on the immune system: the role of the IL-2 family in pancreatic disease
Authors: Zhu Yuqing , Lu Zheng , Wang Zhuo , Liu Jiao , Ning Ke
Published: January 2025

The IL-2 family, consisting of IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21, is a key regulator of the immune response. As an important endocrine and digestive organ, the function of the pancreas is regulated by the immune system. Studies have shown that each cytokine of the IL-2 family influences the occurrence and development of pancreatic diseases by participating in the regulation of the immune system. In this paper, we review the structural and functional characteristics of IL-2 family members, focus on their molecular mechanisms in pancreatic diseases including acute pancreatitis, chronic pancreatitis and pancreatic cancer, and highlight the importance of the related proteins in the regulation of immune response and disease progression, which will provide valuable insights for new biomarkers in pancreatic diseases, early diagnosis of the diseases, assessment of the disease severity, and development of new therapeutic regimens. The insights of the study are summarized in the following sections.
Autoimmune hepatitis under the COVID-19 veil: an analysis of the nature of potential associations
Authors: Yu Chaojie , Wang Wenrui , Zhang Qian , Jin Zhenjing
Published: January 2025

In recent years, the novel coronavirus infectious disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has led to over 670 million infections and nearly 7 million deaths worldwide. The global pandemic of COVID-19 has precipitated a significant public health crisis. The prevalence of liver function abnormalities associated with SARS-CoV-2 is as high as 53% among healthy individuals or patients with autoimmune hepatitis (AIH) and shows a positive correlation with disease severity; moreover, specific adaptive immune responses can influence the trajectory and outcomes of COVID-19. For instance, SARS-CoV-2 may impact autoimmunity through mechanisms such as excessive stimulation of immune responses and molecular mimicry, particularly in genetically predisposed individuals. Currently, the overall mutational trend of SARS-CoV-2 indicates heightened infectivity and immune evasion capabilities. Consequently, vaccination remains crucial for universal protection against this disease. Nevertheless, alongside the widespread implementation of vaccination programs globally, an increasing number of cases have been documented where COVID-19 vaccination appears to trigger new-onset autoimmune hepatitis; yet definitive evidence is still pending elucidation regarding causality. In this review, we analyse the clinical-immunological characteristics, risks associated with severe disease progression, and prognosis for AIH patients infected with SARS-CoV-2; discuss the detrimental effects exerted by SARS-CoV-2 on hepatic function; summarise the mechanisms and attributes leading to new-onset AIH; as well as provide insights into how vaccination may interfere with autoimmunity processes. We continue to underscore the significance of vaccination while aiming to enhance awareness concerning potential risks associated with it—this could facilitate better management strategies for autoimmune diseases along with appropriate adjustments in vaccination protocols. Although the precise triggering mechanism linking COVID-19-related events to AIH remains unclear, existing evidence suggests that this relationship is far from coincidental.
Adjuvant-free, self−assembling ferritin nanoparticle vaccine coupled with influenza virus hemagglutinin protein carrying M1 and PADRE epitopes elicits cross-protective immune responses
Authors: Zhao Yongqiang , Guo Shuangshuang , Liu Jia , Wang Yating , Wang Bo , Peng Chun , Du Enqi
Published: January 2025

Introduction

Influenza viruses pose a significant threat to global public health. Several influenza pandemic outbreaks have had serious economic and public health implications. Current influenza virus vaccines generally provide strain-specific protection and must be rapidly produced annually to match the circulating viruses. Developing influenza vaccines that confer protection against a broad range of viruses will have a positive impact on public health. In this study, we aimed to develop a ferritin-based influenza nanoparticle vaccine with a broad protective spectrum to enhance the immune response against diverse influenza viruses.

Results

We generated an adjuvant-free, self-assembling nanoparticle vaccine against diverse influenza A viruses. This nanoparticle vaccine displayed multi-antigen targets on the surface of Helicobacter pylori ferritin, which consists of the ectodomain of hemagglutinin of the H3N2 virus and three tandem highly conserved influenza M1 epitopes fused with the universal helper T-cell epitope PADRE, named HMP-NP. HMP-NPs were expressed in a soluble form in the baculovirus-insect cell system and self-assembled into homogeneous nanoparticles. Animal immunization studies showed that the HMP-NP nanovaccine elicited 4-fold higher haemagglutination inhibition (HAI) titers than inactivated influenza vaccine. And neutralization titers induced by HMP-NPs against the H3N2 virus and heterologous strains of the H1N1 and H9N2 viruses were ~8, 12.4 and 16 times higher than inactivated influenza vaccine, respectively. Meanwhile, we also observed that the number of IFN-γ- and IL-4-secreting cells induced by HMP-NPs were ~2.5 times higher than inactivated influenza vaccine. Importantly, intranasal immunization with HMP-NPs, without any adjuvant, induced efficient mucosal IgA responses and conferred complete protection against the H3N2 virus, as well as partial protection against the H1N1 and H9N2 viruses and significantly reduced lung viral loads.

Discussion

Overall, our results indicated that the self-assembled nanovaccines increased the potency and breadth of the immune response against various influenza viruses and are a promising delivery platform for developing vaccines with broader protection against emerging influenza viruses and other pathogens.