bluuebunny/crossref_metadata_2025 huggingface dataset:
Religious coping of Malaysian Muslims with high Sensory-Processing Sensitivity in facing the loss of loved one(s)
Authors: Indera Luthfi Nurul Insyirah , Alias Intan Aidura , Mohamad Mardiana
Published: June 2023

Sensory-Processing Sensitivity (SPS) characterizes people’s characteristic sensitivity to experience. SPS is a young field of research. There are limitations in the study of SPS and religiosity and spirituality. This study seeks to explore how Muslims with high SPS view the loss they have experienced and how they cope with the loss from an Islamic perspective. Interpretative Phenomenological Analysis (IPA) was used as the method of the study to allow for an in-depth exploration of how participants make sense of their loss experiences. The study recruited five high SPS Malaysian Muslims to explore the loss and coping experiences they had during the COVID-19 crisis and how they viewed the experiences in Islamic perspectives. The study found three themes in the application of Islamic perspectives in viewing the loss experienced by the participants and the way they coped with the loss. The Malaysian Muslim participants applied Islamic teachings as protective and therapeutic aspects to cope with the loss of loved ones, which is consistent with previous studies on Islamic religiosity. It is recommended that future SPS studies focus on exploring how individuals with different levels of SPS view religiosity and spirituality aspects of life events, especially within the Malaysian Muslim community.
Disrupting nature? A critical analysis of the genderless toilet drive represented in South African newspapers
Authors: Moyo Rachel , Khanyile Sphesihle
Published: June 2023

Global cultures and imperialist Western ways of being and doing pervasively penetrate and influence societies and individuals, overarching the nations at the bottom of development. This globality operates unidirectionally, biased toward the Western gravity of power, excluding, disenfranchising, erasing, and debasing the values of the global South’s peripheries. Consequently, the theory of globalization has focused on how localized groups in subaltern developing countries respond to the weighty forces of globalism. This paper presents a critical analysis that explores the omnipotent ideologicalhegemonic power of the media to cultivate, enculturate, and superimpose values normative to the ethos of global culture. We employ critical discourse analysis to analyze seven selected newspapers that reported on a draft proposal by the Department of Basic Education that envisions the eradication of gender labels through the imposition of genderless toilets in South African schools. Critical reading of the newspaper articles demonstrated clear Afrocentric pushbacks; other counternarratives displayed the societal incongruity of such a vision. The media frames corresponded to audience frames that vehemently rejected the unisex toilet proposition. The frames continue to invite readers to question the redefinition of gender identities and performances that promote global cultural values that supposedly disrupt nature.
IonKit-NH: a MATLAB-based toolkit for ionospheric detection of natural hazard
Authors: Tang Long
Published: June 2023

In recent years, ionospheric sounding by GNSS total electron content (TEC) has been a powerful tool to detect the natural hazard such as earthquake, tsunami and volcanic eruption due to the fact that the natural hazard-produced acoustic waves or gravity waves can travel into the ionosphere and trigger travelling ionospheric disturbances (TIDs).However, open-source program on this field is scarce. Here, we developed a MATLAB-based toolkit, called IonKit-NH, to detection of natural hazard. IonKit-NH is capable of processing multi-system GNSS including GPS, GLONASS, Galileo and BDS and forming different dual-frequency combinations to solve TEC. Based on the GNSS TEC, IonKit-NH generates the time-distance map and two-dimensional map of TEC variation, which can be used to obtain the characteristics of TIDs induced by natural hazard.
RORB, an Alzheimer’s disease susceptibility gene, is associated with viral encephalitis, an Alzheimer’s disease risk factor
Authors: Lehrer Steven , Rheinstein Peter
Published: June 2023

Background: Viral encephalitis increases later-life risk of Alzheimer’s disease (AD) by a factor of 31. Methods: To further evaluate this finding, we examined the relationship of West Nile virus (WNV) to Alzheimer’s disease in 50 US states. In addition, we performed a genome wide association study (GWAS) of viral encephalitis cases in UK Biobank (UKBB) to see if any encephalitis genes might be related to AD. Results: WNV was significantly associated with deaths from Alzheimer’s disease in 50 US states (r = 0.806, p < 0.001). One gene, RORB-AS1, was most significantly related on GWAS to viral encephalitis. RORB-AS1 (RORB Antisense RNA 1) is an RNA gene. Diseases associated with RORB-AS1 include childhood epilepsy and idiopathic generalized epilepsy. The closely related RORB (Related Orphan Receptor B) is a marker of selectively AD vulnerable excitatory neurons in the entorhinal cortex; these neurons are depleted and susceptible to neurofibrillary inclusions during AD progression. RORB variants significantly decreased the risk of AD, independent of the significant effects of epilepsy, age, and years of education. The total effect size of variant RORB on AD prevalence is small, 0.19%, probably the reason RORB has not turned up on genome wide association studies of AD. But the decrease in effect size on AD, no variant versus variant, is larger, 0.20% to 0.16%. To produce the 31-fold increase in AD risk associated with viral encephalitis, non-variant RORB may need to interact with encephalitis virus. Conclusion: data presented here confirm the association of viral encephalitis with AD and suggest that WNV infection is a significant AD risk factor. A human WNV vaccine could reduce Alzheimer’s disease morbidity and mortality. In addition, GWAS suggests that the gene RORB, an AD vulnerability factor, is significantly related to viral encephalitis.
The Influence of War and Global Economy on Article Publication (Bibliometric Analysis using Biblioshiny-R)
Authors: Buyamin Buyamin , Rahayu Budi , Suradi Suradi , Herawaty Istiana , Suryadi Suryadi , Syaifullah Dian Hafit , Kurniawati Ardhian , Syahr Zulfia Hanum Alfi
Published: June 2023

This descriptive qualitative research uses Bibliometric Analysis by utilizing the Biblioshiny-R tool. This research determines the influence of an author, document, affiliation, source, and country in article publication with war and global economy themes. The source of the analysis data with the theme of war and global economy comes from the Scopus database without any restrictions. Weiss MA is the most influential author. At the same time, Liu Y has the highest h index. The University of California is the most influential affiliate, and at the same time, the Cambridge Journal of Economics has the highest h index. The economy is the most influential keyword in the publication. At the same time, the war keyword also appears the most. Gössling S, 2020, J Sustainable Tour and USA are the most influential documents and country publications. Until now, no bibliometric research has been found that discusses the Scopus database on war and the global economy. What is new from this research is the use of Biblioshiny-R in the Scopus database analysis on war and the global economy, which has never been done before. It is hoped that more scientists, students, lecturers, and researchers will be interested in researching the effects of war on the global economy, especially wars that use nuclear and chemical weapons. As a result, the Government can develop policies to anticipate/avoid wars using nuclear and chemical weapons.
Spatiotemporal variation and prediction of NPP in Beijing-Tianjin- Hebei region by coupling PLUS and CASA models
Authors: zhang junping , Wang Jia , Chen Yuhan , Huang Shaodong , Liang Boyi
Published: June 2023

Context
Vegetation productivity is crucial for human production and livelihoods. Monitoring changes in NPP (Net Primary Productivity) is essential to evaluate regional ecological shifts and carbon sink capacity.
Objectives
Our objective is to explore the variations of NPP during 2001–2020 and propose a new idea to predict the actual NPP in 2030 under multiple climate scenarios, taking the Beijing-Tianjin-Hebei (BTH) region as an example.
Methods
This study utilized the PLUS (patch-generating land use simulation) and improved CASA (Carnegie-Ames-Stanford Approach) models, along with remote sensing and climate data, to estimate changes in NPP in the BTH region for the period 2001–2020 and predict NPP in 2030.
Results
The results indicate that, during the period of 2001–2020, the NPP in the research area maintained a spatial distribution pattern, with higher values in the northeastern forest area, a slightly higher value is found in the southeast of the city, while a lower value is found in the northwest and center, showing an overall gradual improvement trend. However, the NPP in the study area is predicted to decline in 2030 compared to 2020, albeit better than that in 2001–2015. Moreover, NPP will decline in 2030 under three future climate scenarios, and the NPP condition is optimal under the SSP 1-2.6 scenario.
Conclusions
NPP will decline in 2030 in the BTH region, it may be related to some current ecological policies. Comparing NPP development under three future climate scenarios, we find that a low-emission scenario, which represents a green development model, is more favorable for the development of NPP. This research sheds light on the variations of NPP in the BTH region and offers a scientific basis for relevant departments to formulate future policies.
Poly(Ethylene Piperidinium)s for Anion Exchange Membranes
Authors: Kim Yoonseob , Chen Huanhuan , Tian Ye , Hu Chuan , Tao Ran , Yuan Yufei , Wang Rui , Shin Dong-Myeong , Shao Minhua , Lee Young Moo
Published: June 2023

The lack of anion exchange membranes (AEMs) that possess both high hydroxide conductivity and stable mechanical and chemical properties poses a major challenge to the development of high-performance fuel cells. Improving one side of the balance between conductivity and stability usually means sacrificing the other. Herein, we used facile, high-yield chemical reactions to design and synthesize a piperidinium polymer with a polyethylene backbone for AEM fuel cell applications. To improve the performance, we introduced ionic crosslinking into high-cationic-ratio AEMs, PEP80-20PS, to suppress high water uptake and swelling while further improving the hydroxide conductivity. Remarkably, PEP80-20PS achieved a hydroxide conductivity of 354.3 mS cm− 1 at 80°C while remaining mechanically stable. Compared with the base polymer PEP80, the water uptake and swelling rates of the ionically crosslinked sample at 80°C decreased substantially by 69% and 85%, respectively. PEP80-20PS also showed excellent alkaline stability, 84.7% remained after 35 days of treatment with an aqueous KOH solution. The chemical design in this study represents a significant advancement toward the development of simultaneously highly stable and conductive AEMs for fuel cell applications.
PPM1H is Down-Regulated by ATF6 and Dephosphorylates p-RPS6KB1 to Inhibit Progression of Hepatocellular Carcinoma
Authors: Yang Xiaoshuang , Guo Jianting , Li Wei , Li Chunrui , Zhu Xilin , Liu Ying , Wu Xiaopan
Published: June 2023

Background: Our previous studies found that polymorphism of activating transcription factor 6 (ATF6) was associated with susceptibility to hepatocellular carcinoma (HCC), and ATF6 promoted HCC progression. So genes down-regulated by ATF6 might play a tumor suppressing role. In present study, we aimed to identify downstream genes down-regulated by ATF6, and clarified its role in HCC progression.Methods: To determine the role of ATF6 on downstream gene expression, qRT-PCR and western blot were performed in HCC cells and liver specifically Atf6-knocked out mice. Tumor tissues from 134 HCC patients were analyzed by immunohistochemistry. Then, MTT, transwell and clone formation assays were performed in hepatoma cells. DEN/CCl4 induced HCC mouse model and nude mice tumorigenicity assay were conducted to investigate the effect of PPM1H on HCC tumorigenesis and development. 3D model of PPM1H was obtained by homology multi-template modeling, the potential substrates of PPM1H were screened by Rosetta and verified through co-immunoprecipitation, western blot and in vitro phosphatase assays.Results: The expression of Protein phosphatase magnesium or manganous dependent 1H (PPM1H) mRNA and protein can be inhibited by ATF6. PPM1H inhibited proliferation, migration, invasion and clone formation of cancer cells. PPM1H inhibited induced HCC nodules formation and tumor xenograft growth in two mouse models. The protein docking energy of RPS6KB1 with PPM1H in the BMP/TGFβ pathway is the lowest, and PPM1H directly dephosphorylated p-RPS6KB1. PPM1H exhibited higher expression level in adjacent para-cancer tissues than in HCC tissues. Patients with higher expression of PPM1H indicated a better prognosis.Conclusions: We first discovered RPS6KB1 as a new PPM1H dephosphorylation substrate. PPM1H exhibited suppressive effect on the progression of HCC through dephosphorylating p-RPS6KB1. This might contribute to finding novel target for therapy of HCC.
Optimization of Greenhouse Microclimate Parameters
Considering the Impact of CO2 and Light
Authors: Sokolov Serhii
Published: June 2023

The most critical parameters of the microclimate in greenhouses are air and soil temperature, air and soil moisture, plant illumination, and carbon dioxide (CO2) concentration in photosynthesis. New energy sources and resource-efficient management of microclimate parameters in greenhouses can be utilized to reduce greenhouse crop cultivation costs and increase profits. As the plant mass increase depends on photosynthesis, which involves the formation of glucose in the plant chloroplasts from water and carbon dioxide under the influence of light radiation, the saturation of greenhouses with carbon dioxide has become popular in recent decades. However, insufficient light slows down the process of glucose formation, while excessive light intensity negatively affects photosynthesis. Based on the experimentally proven Van Henten model of plant growth and using the MATLAB environment, a methodology was proposed, and the dependence between CO2 concentration and leaf lettuce illumination power required for maximum photosynthesis was determined. It is equal to 0.57 ppm/(W/m2). Such dependence should be considered when designing control systems to reduce resource and energy costs for greenhouse crop cultivation while ensuring maximum yield.
Soft budget constraints in Polish public healthcare entities
Authors: Dobrowolski Zbysław , Sługocki Waldemar , Kachniarz Marian , Babczuk Arkadiusz
Published: June 2023

Although the theory of soft budget constraints is widely presented in the literature, little is known about the factors of soft budget constraints in public hospitals in Poland. This study is relevant because many Polish hospitals struggle with serious debt problems. The study aims to systematise the regulatory and legal provision of soft budget restrictions in the activities of healthcare institutions, particularly public hospitals in Poland, and to assess the impact of these restrictions on their further functioning. An analysis of hospitals’ regulatory and legal activities shows the implementation of various soft budget restrictions. On November 20, 2019, Poland returned to the soft budget constraints, which functioned immediately after the introduction of reforms in the late 90s of the last century. As of 2021, out-of-pocket costs for treatment have decreased to 19.56%, but costs are gradually increasing and in 2020, according to the World Bank, they amounted to 71.89%. The provision of medical services mainly by public hospitals owned by local governments and scattered healthcare debt make it difficult to liquidate an inefficient public hospital in the event of its default. The study proves that the main reason for not eliminating the soft budgetary constraints of hospitals through their commercialization was the inconsistency of the carried out reform of commercialization of hospitals with the financial condition of local authorities.
AcknowledgmentThe authors thank the Institute of Economic and Financial Expertise in Łódź for financial support in publishing this paper.
What HR decisions are crucial in turbulent times? An analysis of differences in manufacturing and non-manufacturing companies
Authors: Šikyř Martin , Skypalova Renata , Vavrova Jana
Published: June 2023

Manufacturing and non-manufacturing companies are represented to varying degrees in the structure of advanced economies. Their business success in turbulent times depends on smart business decisions, including decisions concerning human resources (HR) that affect the companies’ ability to survive and compete. However, such judgments may differ in manufacturing and non-manufacturing companies. The paper aims to reveal potential differences in HR decisions between analyzed manufacturing and non-manufacturing companies and bring suggestions for challenging employment and compensation decisions that affect the companies’ economic and social position. The analysis uses the HR Analysis in Companies 2023 survey conducted by Gi Group/Grafton Recruitment Czech Republic at the end of 2022. The survey covered responses from 478 manufacturing and non-manufacturing companies in all fourteen regions of the Czech Republic regarding employment and compensation decisions in 2022 and plans for 2023. The analysis revealed tendencies of manufacturing companies to change the total number of employees and the offer of benefits more often than non-manufacturing companies to more flexibly change the labor demand and labor costs depending on the demand for final production. On the other hand, regardless of manufacturing or non-manufacturing companies, the overall findings revealed tendencies of surveyed companies to follow certain HR decisions from the past in the future and confirm the necessity to concentrate on effective HR decisions related to employment and compensation in turbulent times to manage the labor demand and labor costs efficiently.
AcknowledgmentThe authors thank Gi Group/Grafton Recruitment Czech Republic for providing the HR Analysis in Companies 2023 survey and the Internal Grant Agency of Ambis College for financial support to create this article.
Neoplasms – biological phenomenon
Authors: MADEJ JANUSZ A. , DANILUK JAKUB , MADEJ PAWEŁ
Published: June 2023

Neoplasm is the cause of a double disease of the body, i.e. with two faces (Janus disease), which means both the presence of cancer cells and the secondary disorders of the immune system function caused by them. The second possibility is a temporary decrease in immunity, caused by e.g. influenza, and revealing a neoplastic disease. Neoplasms are induced by both genetic and epigenetic factors (Fig. 1), giving different types of mono- and polyclonal metastases and cross-spreading (Fig. 2). Recently, exosomes have been ascribed an important role in the formation of metastases. They transfer information between normal and cancer cells by horizontal transfer and „teach” myeloid cells to move to the pre-metastatic niche and the metastatic deposit. In carcinogenesis, the main role is played by long-lived cancer stem cells, as well as differentiated cells after they have gained the ability to self-renew, as in stem cells. The paper also presents examples of neoplasms accompanied by a second, primary neoplasm in the same system or in the vicinity. Multiple primary malignances (MPM) associated with them have also been described. With the help of the so-called strange attractor, an attempt was made to describe the behavior of cancers in connection with the phenomenon of deterministic chaos based on the process of entropy. Distinguishing between chaotic and stochastic (random) systems is very difficult in biology.
THE PROBLEM OF EVALUATING THE EFFECTIVENESS OF POLITICAL COMMUNICATIONS IN SOCIAL MEDIA
Authors:   St. Petersburg State University, Kurochkin Aleksandr
Published: June 2023

The article deals with the problems of analyzing political communications in social media carried out in conditions of global instability and a sharp increase in international and interregional confrontation caused, in addition to political reasons, by competition for dwindling resources. In such conditions, manipulative technologies are spreading extremely dynamically and the value foundations of politics are being lost. The key characteristics of network communication are: anonymity, non-normativity and non-linearity, which greatly complicates the conduct of such an analysis. An even more difficult research task is to evaluate the effectiveness of this kind of communication. Analyzing the complexity of conceptualization and operationalization of the effectiveness of political communication, the author suggests using the term «communicative effectiveness», the methodological prerequisites of which are the theory of agreements presented in the works of modern French neo-institutionalists: L. Boltyansky, L. Theveno, O. Favoro, etc. Having illustrated his analysis with several cases of network political communication in recent years, the author comes to the conclusion that it is necessary to assign the category of «trust» to the central criteria for evaluating the effectiveness of political communication.
OPPORTUNITIES AND FEATURES OF THE WORLDVIEW FORMATION IN THE DIGITAL COMMUNICATION ENVIRONMENT: BASED ON THE MATERIALS OF AN EXPERT STUDY
Authors:   State Academic University of Humanities, Volodenkov Sergey , Fedorchenko Sergey ,   State Academic University of Humanities, Pechenkin Nikolai ,   State Academic University of Humanities
Published: June 2023

This article is devoted to identifying the features of the formation and transformation of the worldview and its key components in the context of the intensive development of the modern digital communication environment. In this regard, the paper puts forward a research hypothesis that the digital information and communication environment, as well as digital communication technologies, mechanics, affordances and algorithms, are not value-neutral and have the potential to influence the content aspects of the worldview of individuals. To confirm this hypothesis, the authors carried out a discourse analysis of modern research on this issue, as well as an international expert study with the aggregation and analysis of the results. The article defines and discusses the peculiarities of the influence of digital tools on the mass perceptions of users of the digital environment about objective reality, as well as on traditional worldview and value-semantic models. Based on the results of the study, a conclusion was drawn about the high level of value coloring and the significant impact of the digital information and communication environment, as well as digital communication technologies, mechanics, affordances, and algorithms on the modern worldview of individuals. It is concluded that the modern space of digital communications has acquired an independent ontological status, which, in the context of a significant drop in the volume of direct experience of the interaction of individuals with reality, is the foundation for intensive replacement of traditional ways of understanding the world and of the formation of worldview ideas through real social interaction with digital, maximally virtualized ways of understanding the world. The authors also conclude that high speed and intensity, seeming randomness and multidirectionality, as well as the high dynamics of the structure of digital communications, determine the crisis of the value-semantic and worldview self-identification of a modern person.
CURRENT METHODS OF COMMUNICATION OF PUBLIC POLITICIANS OF MOSCOW WITH CITIZENS IN THE INTERNET SPACE (ON THE EXAMPLE OF THE ELECTIONS TO THE STATE DUMA IN 2021)
Authors:   Financial University under the Government of the Russian Federation, Belokonev Sergei , Ivanov Vladimir ,   Peoples’ Friendship University of Russia named after Patrice Lumumba, Levina Elena ,   Financial University under the Government of the Russian Federation
Published: June 2023

The digital transformation of all spheres of society has led to the need to develop Internet communications and increase the importance of social networks as platforms for discussing and broadcasting positions. The purpose of this work is to analyze and evaluate the activity of public politicians in Moscow in social networks to develop practical recommendations for conducting Internet communications. In the course of the research, the authors of the article used structural-functional and systematic approaches to determine the key parameters of building communications in the virtual space; discourse analysis and technologies of social media predictive analytics to study the posted content, its tonality and the dynamics of discussions both in social media and on the Internet in general; as well as classification and generalization methods for highlighting the main types of page maintenance by public politicians in social networks. The set of methods used made it possible to give a comprehensive assessment of the positioning of public politicians in the Internet space. In the course of the study, a qualitative and quantitative analysis of the content posted on social media by both public politicians on the pages of their own social networks and the audience discussing their activities was carried out; the types of maintaining pages in social networks by politicians of different levels are highlighted: federal, regional and municipal; the strengths and weaknesses of each type are identified. The authors of the article analyzed the main indicators that determine the effectiveness of public politicians' pages in social networks, identified the most popular communication platforms, developed recommendations and techniques for Internet communication of public politicians in Moscow with citizens. The results obtained in the course of the study can be used by public politicians in their activities both in the context of the implementation of election campaigns, and for regular interaction with their audience, as well as by research scientists for further in-depth study.
FEATURES DIGITAL GOVERNMENT AND SECURITY LEGAL REGULATION IN CONTEMPORARY RUSSIA
Authors:   St. Petersburg State University, Morozova Svetlana , Smirnova Iuliia ,   St. Petersburg State University
Published: June 2023

Digital reality is becoming an integral part of the modern world, in which there are new ways of interaction between individuals and the functioning of state institutions. The COVID-19 pandemic has presented the concepts of «digital state» and «digital citizen» as a kind of challenge not only to the state, but also to society itself, which necessitated clarification and legitimization of these concepts in the legal field of the Russian Federation. The article reveals the key features of the Russian practice of digital governance and security legal regulation. Based on an analysis of the existing legislative framework in the Russian Federation in the field of digitalization and digital security, and, in particular, such significant initiatives in recent years as the draft Concept «Ensuring the protection, rights and freedoms of man and citizen in the digital space», as well as relying on a significant amount of accumulated over decades of research on scientific knowledge on this topic and statistical data (Global Cybersecurity Index), the authors identify both the strengths and weaknesses of modern Russian digital law. So, if high-quality legal regulation of a strategic orientation was singled out as the main positive feature of domestic legislative practice in the context of digitalization, then the intersection and imposition of the norms of different branches of law, together with the lack of legal norms’ systematization, were identified as the central problem of modern Russian digital legislation. The final part of this article is a set of proposals and recommendations for improving the legislative regulation of digital governance and security. The authors propose to pay more attention to public authorities to control the implementation of cybersecurity policies, as well as legislate the distribution of powers and responsibilities among the relevant government agencies.
AUDIT OF THE YOUTH POLICY ECOSYSTEM IN THE RUSSIAN FEDERATION IN THE CONTEXT OF DIGITALIZATION: A RISK-REFLEXIVE APPROACH (PART 1)
Authors:   St. Petersburg State University, Aleinikov Andrei , Maltseva Daria ,   St. Petersburg State University, Tuzova Polina ,   St. Petersburg State University
Published: June 2023

The main goal of the presented study is to analyze the features of the development of state youth policy in the Russian Federation in the context of digitalization. The authors start from the modern understanding of the foundations of social audit as a critical analysis of the efficiency of modern youth policy through the study of mechanisms and methods, processes of constituting meanings and gaining the rights of young people to self-realization and social innovation, achieving a conflict balance of their expectations with institutional norms and resources. As the main theoretical tool for auditing the efficiency of youth policy in the digital environment, the potential of a risk-reflexive approach to assessing interactions and conflict/cooperation between society and the state in generational optics is used. The ideas of risk-reflexive management are considered as a normative basis for focusing the audit of youth policy not only on institutions and organizational structures, but above all on values and meanings. The audit of youth policy is disclosed in the article as a check for the compliance of its goals and methods with the tasks of youth socialization, its adaptation in a risky society in the context of global information confrontation and risk assessment. The article proposes a risk-reflexive interpretation of the criteria for the efficiency of strategic management in the field of youth policy implementation (productivity, security, development, satisfaction). Based on the analysis of the social capital concept, its “triad” (trust, cultural norms and social networks) and forms, the article reveals the specific features of strategies for young people to choose models of response to social and political problems, proposes an original classification of youth policy using “bonding” and “bridging” types.
Short Synthetic Peptides as COX-2 Inhibitor with Antiproliferative Activity:
A Probable Future Class of Drugs
Authors: Ali Fazid , Ahmed Momitul , Kushari Susankar , Banu Zartaj Washmin , Laloo Damiki , Kalita Jun Moni
Published: June 2023

Cancer remains a leading cause of death worldwide, with traditional chemotherapy
treatments causing significant side effects. Short synthetic peptides have emerged as a potential
alternative due to their unique properties, including selectivity, stability and biocompatibility. Recent
research has shown that short peptides can act as effective anticancer agents through their ability
to inhibit the COX-2 (Cyclooxegenase-2) enzyme, a key enzyme involved in tumor growth and
progression. In particular, short peptides have demonstrated promising results in targeting the tumor
microenvironment, disrupting angiogenesis, and inducing apoptosis in cancer cells. This review summarizes
the current literature on short peptides as anticancer agents, including their mechanisms of
action and future directions for research and development. The results suggest that short peptides hold
significant potential as a new class of anticancer agents and warrant further investigation.
Editorial
Authors: Vanlee Florian , Van Raemdonck An
Published: June 2023

DiGeSt 10(1) General Issue - Editorial
PENGARUH PEMBERIAN AIR PERASAN DAUN KIPAHIT (Tithonia diversifolia) SEBAGAI PESTISIDA NABATI PENGENDALIAN HAMA Plutella xylostella PADA TANAMAN SAWI (Brassica juncea)
Authors: Rifah Lia Mamba'atu Salamatir , Djukri Djukri
Published: June 2023

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian air perasan daun kipahit (Tithonia diversifolia)terhadap mortalitas hama Plutella xylostella, sebagai pestisida nabati hama Plutella xylostella pada tanaman sawi,mengetahui pengaruh pemberian air perasan daun kipahit (Tithonia diversifolia) terhadap jumlah pupa, danmengetahui pengaruh pemberian air perasan daun kipahit (Tithonia diversifolia) terhadap kerusakan tanaman sawi.Penelitian ini dilaksanakan di Green House FMIPA UNY pada bulan Januari-Maret 2018. Penelitian ini adalahPenelitian Eksperimen dengan perlakuan variasi dosis air perasan daun kipahit. Dosis air perasan daun kipahit yangdigunakan yaitu 0%, 10%, 15%, 20% dan 25%. Analisis data menggunakan uji One Way Anova dilanjutkandengan uji Duncan. Hasil penelitian menunjukkan pemberian air perasan daun kipahit pada dosis 25% berpengaruhterhadap mortalitas larva Plutella xylostella, tidak berpengaruh terhadap pembentukan jumlah pupa, dan tidakberpengaruh terhadap kerusakan tanaman sawi.Kata kunci: Tithonia diversifolia, Plutella xylostella
PENGARUH VARIASI JENIS PUPUK TERHADAP PERTUMBUHAN DAN PERKEMBANGAN TANAMAN TOMAT (Lycopersicum esculentum var. Intan)
Authors: Farastuti Ditya , Henuhili Victoria
Published: June 2023

Tomat merupakan salah satu komoditas buah populer dan banyak dikonsumsimasyarakat. Petani biasanya membudidayakan tanaman tomat dengan pupuk kimia anorganikNPK, pemberian pupuk dalam jangka waktu lama dapat menurunkan kesuburan tanah. Saatini penggunaan pupuk organik seperti pupuk kandang, pupuk kompos, dan pupuk kascingbanyak digunakan karena berpotensi menyuburkan tanah kembali dan meningkatkan produksitanaman tomat. Hal ini mendorong untuk dilakukan penelitian yang bertujuan mendapatkanjenis pupuk paling baik atau berpotensi dijadikan campuran dalam mendukung pertumbuhandan produksi tanaman tomat.Desain penelitian menggunakan rancangan acak lengkap (RAL). Penelitiandilaksanakan bulan Mei-Agustus 2015 bertempat di lahan pertanian percobaan UGM,Banguntapan, Bantul. Dosis pupuk yang digunakan yaitu 0,02 kg/m2 pupuk NPK (PU), 2kg/m2 pupuk kandang (PK), 2 kg/m2pupuk kompos (PKM), dan 2 kg/m2 pupuk kascing (PC).Setiap plot berukuran 2x2 m2berisi 16 tanaman tomat, masing-masing perlakuan mempunyai5 ulangan plot. Pengamatan dilakukan 2 minggu sekali selama 5 kali pengamatan.Hasil penelitian menunjukkan pertumbuhan tanaman tomat untuk pengukuran reratatanaman tertinggi adalah pada plot PU 35,7cm, rerata jumlah daun terbanyak pada plot PKM86,14 helai daun/plot, dan rerata diameter batang terbesar pada plot PU 7,80cm.Perkembangan bunga pada fase anthesis tertinggi pada plot PU rerata 1,73 bunga per plot.Fase perkembangan buah pada pembesaran vesikel tertinggi pada plot PU rerata 4,15 buah perplot dan fase pematangan buah terbanyak pada plot PKM rerata 0,15 buah per plot. Datapanen tomat terbanyak pada plot PU total 15,4 kg/20m2. Pupuk yang memberikan hasilterbaik dari penelitian ini adalah PU dan PKM. Efek pengaruh variasi pupuk organik dananorganik tidak terlihat nyata terhadap pertumbuhan dan perkembangan tanaman tomat,berdasarkan hasil uji analisis ragam pada pertumbuhan (Sig.0,05), sedangkan rerata jumlahbunga dan rerata jumlah buah saat panen yang tidak terpaut jauh satu sama lain.Kata kunci: Tanaman tomat, variasi jenis pupuk, pertumbuhan dan perkembangan tanaman
CARA PRODUKSI PANGAN YANG BAIK (CPPB) PADA PEMBUATAN ES PUTER
Authors: Vadila Silvy Wening , Rahayu Tutiek
Published: June 2023

Penelitian ini bertujuan mengetahui perbedaan penerapan CPPB pada pembuatan es puter,mengetahui perbedaan titik kritis pembuatan es puter A dan B bedasarkan pelaksanaan CPPB ,danmengetahui perbedaan mutu keamanan pangan produk es puter pembuat A dan B berdasarkan hasilpelaksanaan CPPB. Penelitian ini merupakan penelitian deskriptif observasi, pengambilan sampeldilakukan dengan cara pengundian. Hasil penerapan CPPB tidak ada perbedaan , pada pembuatan es puterA dan B pada lingkup bahan sudah sesuai dengan spesifikasi bahan baku dan pada tahapan prosespembuatan terdapat penyimpangan yakni pada alat, pekerja, dan lingkungan. Kedua pembuat es puter Adan B memiliki titik kritis yang berasal dari pekerja, tempat, dan peralatan. Hasil uji fisik es puter A danB tidak ada perbedaan, keduanya terdapat benda asing berupa serpihan kulit kelapa dan pasir. Hasil ujikimia sakarin es puter di pembuat A dan B negatif, pH air baku es puter A yakni 6 dan es puter B yakni 7.Hasil uji mikrobiologis coliform es puter pembuat A dan B pada ke tiga kriteria ½ jadi, jadi (0 jam), danakan habis (12 jam) menunjukkan hasil positif 110 MPN/mL.Kata kunci: es puter,CPPB, titik kritis, fisik, kimia, mikrobiologi.
BAC, Siembra y Linkata: sistemas de información al servicio del sector agropecuario colombiano
Authors:   Corporación Colombiana de Investigación Agropecuaria - AGROSAVIA
Published: June 2023

Los sistemas de información administrados por AGROSAVIA, al servicio del sector agropecuario, son herramientas en entornos digitales y presenciales, que promueven el uso y la apropiación de la información en materia de Ciencia, Tecnología e Innovación Agropecuaria Agropecuaria (CTIA) facilitan la gestión del conocimiento, prestan servicios especializados y facilitan la interacción entre los actores del Sistema Nacional de Innovación Agropecuaria (SNIA).
An App to Support Fathers’ Mental Health and Well-Being: User-Centered Development Study
Authors: Liverpool Shaun , Eisenstadt Mia , Mulligan Smith Aoife , Kozhevnikova Sofia
Published: June 2023

Background

Numerous studies describe the popularity and usefulness of parenting programs. In particular, parenting programs are generally viewed as effective for supporting parents’ mental well-being during key transition periods. However, the evidence base for fathers is limited owing to their lack of involvement in parenting programs and scarcity of tailored support.

Objective

This paper aimed to describe the co-design process for a universal digital intervention for fathers (fatherli) and the outline of a logic model with its expected outcomes.

Methods

Following established guidelines for co-designing and developing complex interventions, we conducted a nonsystematic review of the available literature to gather key information, developed market surveys to assess fathers’ needs and interests, consulted with key stakeholders to obtain expert opinions, and engaged in a rapid iterative prototyping process with app developers. Each step was summarized, and the information was collated and integrated to inform a logic model and the features of the resulting intervention.

Results

The steps in the co-design process confirmed a need for and interest in a digital intervention for fathers. In response to this finding, fatherli was developed, consisting of 5 key features: a discussion forum for anyone to post information about various topics (the forum), a socializing platform for fathers to create and engage with others in small groups about topics or points of shared interest (dad hub), a tool for fathers to find other fathers with shared interests or within the same geographic location (dad finder), a resource for fathers to access up-to-date information about topics that interest them (dad wiki), and a portal to book sessions with coaches who specialize in different topics (dad coaching space). The evidence-based logic model proposes that if fatherli is successfully implemented, important outcomes such as increased parental efficacy and mental health help-seeking behaviors may be observed.

Conclusions

We documented the co-design and development process of fatherli, which confirmed that it is possible to use input from end users and experts, integrated with theory and research evidence, to create suitable digital well-being interventions for fathers. In general, the key findings suggest that an app that facilitates connection, communication, and psychoeducation may appeal to fathers. Further studies will now focus on acceptability, feasibility, and effectiveness. Feedback gathered during pilot-testing will inform any further developments in the app to increase its applicability to fathers and its usability.
Application of non-invasive methods of assessment of steatosis and fibrosis in chronic diffuse liver diseases of various etiologies
Authors: Stepanov Yu.M. , Didenko V.I. , Petishko O.P. , Galinska A.M.
Published: June 2023

Background. The aim of the study is to analyze the parameters of liver steatosis and fibrosis based on shear wave elastography (SWE) and steatometry data in patients with chronic diffuse liver diseases, taking into account the etiological factor, and determine the diagnostic accuracy of SWE in the diagnosis of liver fibrosis. ­Materials and methods. Three hundred and sixty-four patients with chronic diffuse liver disease aged (48.00 ± 1.84) years were examined, 159 (43.7 %) were male, and 205 (56.3 %) female. The patients were divided into groups: 108 people with non-alcoholic fatty liver disease (NAFLD), 143 with chronic hepatitis C (HCV), 56 with alcoholic liver disease (ALD), and 57 with drug-induced toxic hepatitis. In all patients, SWE and steatometry were performed by Soneus P7 device (Kharkiv, Ukraine) with the liver stiffness and ultrasound attenuation coefficient measurement. Results. According to SWE data, 270 (74.2 %) patients with chronic liver disease had fibrotic changes in the liver. A significant increase in liver stiffness by 1.9 times (p < 0.05) according to Young’s modulus was found in HCV patients and by 1.4 times (p < 0.05) in ALD patients compared to the control group, by 1.7 (p < 0.05) and 1.3 times (p < 0.05), respectively, compared to the group of patients with NAFLD. According to steatometry data, an increase in ultrasound attenuation coefficient by 30.2 % (p < 0.05) in patients with NAFLD, by 27.5 % (p < 0.05) in those with ALD and by 22 % (p < 0.05) in people with toxic hepatitis was found compared to the control group. In patients with liver fibrosis, the median liver stiffness was 6.70 kPa (6.35, 7.56), while in those without liver fibrosis, this parameter was 1.2 times lower (p < 0.01). Histological evaluation of liver samples obtained through percutaneous biopsy in 75 patients with chronic liver disease demonstrated the absence of fibrosis in 14 (18.7 %) cases. According to the results of the ROC analysis, the cut-off value of the liver stiffness determined by SWE was 5.79 kPa, confirming the presence of liver fibrosis in patients with chronic liver disease regardless of etiology (AUC = 0.901, p < 0.001). Conclusions. The liver stiffness determined by SWE in HCV and ALD patients was higher than in NAFLD patients (p < 0.05), as well as the frequency of F3–4 stages of liver fibrosis (p < 0.05). The threshold value of the liver stiffness for liver fibrosis diagnosis in chronic liver disease regardless of etiology was 5.79 kPa (sensitivity 100.0 %, specificity 85.7 %), which allows the family doctor to form a risk group of patients who needed dynamic monitoring with a further investigation of the etiological factor of liver fibrosis.
Nature of intestinal microflora disorders in cardiovascular diseases
Authors: Stepanov Yu.M. , Budzak I.Ya.
Published: June 2023

The article reviews the literature on the relationship between intestinal microflora and cardiometabolic disorders. The pathophysiological significance of microflora disturbance in the development of intestinal pathology has long been known and proven. However, scientific research in recent decades has convincingly proven that the positive role of intestinal microbiota is not limited only to the intestines. Disturbances of the intestinal microbiota can affect other organs and systems, in particular, cardiometabolic processes. The mechanism of the relationship between dysbiotic disorders and the cardiovascular system can occur due to the deterioration of the intestinal barrier function and through the influence of various metabolites of the intestinal microflora on cardiometabolic processes. When the intestinal barrier deteriorates, pro-inflammatory harmful components of the intestinal microflora such as lipopolysaccharides can have a negative effect on the cardiovascular system. Short-chain fatty acids, bile acids, and trimethylamine N-oxide are of the greatest importance among the metabolites of the intestinal microflora, which can have a diverse effect on cardiometabolic processes. Accumulated research data indicate the possible impact of intestinal microflora disturbances on atherosclerosis, hypertension, and chronic heart failure. The search for methods of correcting the intestinal flora is underway, which would allow to eliminate the specified negative impact.
A comparative study Beckett’s Waiting for Godot and Ionesco’s Rhinoceros
Authors: Das Rimasree
Published: June 2023

The definition of ludicrous according to Eugene Ionesco is "that which is devoid of purpose. Man is lost when he is cut off from his transcendental, philosophical, and theological origins; all of his activities become ludicrous, meaningless, and pointless. Every time Ionesco defines the term ridiculous by referring to the same concept of the absurd, his representation of the absurd infers a paradox. The term "absurd" doesn't have a clear definition. Therefore, despite all attempts to provide meaning, the absurdity of the ludicrous exists in the situation of meaninglessness. The word "absurd" defies easy interpretation in Camus and Ionesco's statements. Ultimately, it is impossible to definitively define the word "absurd". How therefore may the concept of the Theatre of the Absurd be defined? The term's creator and leading theorist, Martin Esslin, claims that "the Theatre of the Absurd is a part of the "anti-literary" movement, which has found expression in abstract painting with its rejection of "literary" elements in pictures or in France's "new novel" with its reliance on the description of the objects and rejection of empathy and anthropomorphism." Esslin, like Camus and Ionesco, doesn't give the concept of the ridiculous a specific meaning. Instead, he is able to draw attention to the connection between European literature and abstract art from the 1940s and 1950s. A literary text either imparts or asks for the process of concretization anytime it interacts with the reader, therefore there may be an "abstract" painting but not a "abstract" piece of literature, one could say. "Absurdity" of the literary text appears to be the equivalent of "abstractness" in art in Beckett's "Waiting for Godot" and Ionesco's "Rhinoceros" due to the ways in which both concepts contest the established structures by undervaluing ideas or disobeying the rules of artistic and literary production in art and literature. However, these two works touch on the subject of resistance in the process of enacting it. As a result, a counter-performance occurs in Beckett's text, inviting the reader to interpret it in a different way. Or, the text of Ionesco shows a character against the enigmatically alluring, jouissance-like harmony of the rhinoceroses. Resistance ends up being the only defining trait of "Literature of the Absurd". Additionally, the absurdity of these poems is a result of resistance. Resistances represent both the idea of absurdity and the texts of the Theatre of the Absurd. As a conclusion, we might state that the concepts "absurd" and "absurdity" defy accurate definition and clear interpretation. Certain referents and signifieds cannot under any circumstances be associated with these words. Second, the absurdity of the texts is created by resistances that either the narration or the literary text's structure exhibits in the works that Martin Esslin refers to as texts of the Theatre of the Absurd. Exploration of the word "resistance" is necessary here.