bluuebunny/crossref_metadata_2025 huggingface dataset:
Social Science–Environmental Health Collaborations
Authors: Matz Jacob , Brown Phil , Brody Julia Green
Published: August 2016

The Social Science-Environmental Health Collaborations Conference in May 2016 was a unique gathering of scholars from the social sciences and environmental health sciences, government agency professionals, community organizers and activists, and students. Conference participants described the research and practice of environmental public health as done through a transdisciplinary lens and with a community-based participatory research/community-engaged research model. NIEHS’ role in supporting such work has helped create a growing number of social and environmental health scientists who cross boundaries as they work with each other and with community-based organizations.
An approximate method for solving fractional optimal control problems by hybrid functions
Authors: Mashayekhi S , Razzaghi M
Published: August 2016

In this paper, a new numerical method for solving fractional optimal control problems by using hybrid functions is presented. The Riemann–Liouville fractional integral operator for hybrid functions is utilized to reduce the solution of optimal control problems to a nonlinear programming one, to which existing, well-developed algorithms may be applied. The method is computationally very attractive and gives very accurate results.
Who Are the Men Caring for Maltreated Youth? Male Primary Caregivers in the Child Welfare System
Authors: Ayer Lynsay , Woldetsadik Mahlet A. , Malsberger Rosalie , Burgette Lane F. , Kohl Patricia L.
Published: August 2016

The goal of this study is to better understand the characteristics of men who act as primary caregivers of maltreated children. We examined differences between male primary caregivers (fathers) for youth involved in the child welfare system and female primary caregivers (mothers). We conducted secondary data analyses of the National Survey of Child and Adolescent Well-Being-II baseline data. Overall, primary caregiving fathers and mothers were more similar than different, though a few differences were revealed. Compared to mothers, fathers tended to be older and were more likely to be employed, with a higher household income and older children. Fathers and mothers did not differ in terms of depression or parenting behavior, but there was evidence that mothers have more problems with drug use compared to fathers. Compared to fathers, mothers reported higher levels of internalizing and externalizing problems in their children. Children with male primary caregivers were more likely to have experienced physical abuse but less likely to have experienced emotional abuse or witnessed domestic violence than children with female primary caregivers. These findings may help to inform researchers, practitioners, and policy makers on how to address the needs of male caregivers and their children.
The Matter of New Media Making
Authors: Ehret Christian , Hollett Ty , Jocius Robin
Published: August 2016

Representational logic cannot account for the entanglements of all that matters in making new media: feeling bodies, vibrant matter, feeling bodies and vibrant matter all moving and at different rates. In the currently shifting communicative landscape, where mobile technologies are the primary means for youths’ digital production, all this movement, all this moving matter, is integral to generating fuller, more (than) human expressions of youths’ new media making. This article therefore develops a non-representational theory of new media making through an intra-action analysis of five adolescents making a digital book trailer while moving within and across three locations. As guiding poststructural methodology, intra-action analysis attuned the authors to moments when bodies-materials-place became perceptibly entangled in the drawing of boundaries and exclusions. Analysis expresses how emergent (re)shapings of boundaries and exclusions across production settings were concurrent with a process of privileging text-based/media-based ideas and thereby various students’ becoming agencies and capacities to act as new media makers. The article concludes arguing that poststructural attention to literacy in the making matters as an ethical imperative for researchers and educators. Literacy in the making enacts boundaries and exclusions that participate in ongoing discursive-material practices, which have potential to produce histories differently in as yet unimagined futures.
The Efficacy of Cognitive Behavioral Therapy for Adults With ADHD: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Young Zoe , Moghaddam Nima , Tickle Anna
Published: August 2016

Objective: To systematically review the literature on published randomized controlled trials (RCTs) of cognitive behavioral therapy (CBT) for adult ADHD and to establish the effectiveness of CBT in reducing ADHD symptoms. Method: A systematic review of nine RCTs and two subsequent meta-analyses of eight of the studies were conducted. Results: Just nine studies were identified, of generally good quality but with some limitations. Four trials (total N = 160) compared CBT with waiting list controls, and three trials (total N = 191) compared CBT with appropriate active control groups. Meta-analyses showed that CBT was superior to waiting list with a moderate to large effect size (standardized mean difference [SMD] = 0.76, 95% confidence interval [CI] [0.21, 1.31], p = .006) and superior to active control groups with a small to moderate effect size (SMD = 0.43, 95% CI [0.14, 0.71], p = .004). Conclusion: These results give support to the efficacy of CBT in reducing symptoms of ADHD post-intervention.
Joining The Conversation On Inclusive Masculinity Theory
Authors: Borkowska Katarzyna
Published: August 2016

This paper is a response to Rachel O’Neill’s article “Whither Critical Masculinity Studies? Notes on Inclusive Masculinity Theory, Postfeminism, and Sexual Politics.” It is suggested that her interpretation of the inclusive masculinity theory devalues Anderson’s (2009) perspectives, which focus on democratization of gender relations. Scholars of masculinity work in different conceptual frameworks, contributing to diverse aspects of ideological, political, and social agendas. Thus, it is argued that Anderson’s research recognizes the cultural transformations related to social justice and gender equality and contributes significantly to the field of masculinity studies.
Evaluation Capacity Building in the Context of Military Psychological Health
Authors: Hilton Lara , Libretto Salvatore
Published: August 2016

The need for evaluation capacity building (ECB) in military psychological health is apparent in light of the proliferation of newly developed, yet untested programs coupled with the lack of internal evaluation expertise. This study addresses these deficiencies by utilizing Preskill and Boyle’s multidisciplinary ECB model within a post-traumatic stress disorder treatment program. This model outlines a theoretical framework, offers practical strategies, and emphasizes both context and culture, which are paramount in military health-care settings. This study found that the model provides a highly applicable ECB framework that includes ways to identify ECB objectives, tailor activities, and understand outcomes. While there was high utilization of ECB activities by program staff, there was misaligned evaluative thinking, which ultimately truncated sustainable evaluation practice. Based on this research, evaluators can better understand how to provide an ECB intervention in a complex cultural and political environment and assess its effectiveness.
The impact of 2015 neuromyelitis optica spectrum disorders criteria on diagnostic rates
Authors: Hamid Shahd HM , Elsone Liene , Mutch Kerry , Solomon Tom , Jacob Anu
Published: August 2016

Background:

The international panel for neuromyelitis optica (NMO) diagnosis has proposed diagnostic criteria for neuromyelitis optica spectrum disorders (NMOSD).

Objectives:

We assessed the impact of these criteria on diagnostic rates in a large cohort of patients.

Methods:

We identified and applied the 2006 and 2015 criteria to all patients ( n = 176) seen in the NMO and non-multiple sclerosis central nervous system demyelination clinic (part of the UK NMO service) from January 2013 to May 2015.

Results:

The 2006 criteria classified 63 of 176 (36%) patients as NMO. A total of 42 patients (67%) were aquaporin 4 (AQP4) immunoglobulin G (IgG) +ve and 21 (33%) AQP4 IgG −ve. The 2015 criteria classified 111 of 176 (63%) patients as NMOSD, of which 81 (73%) were AQP4 IgG +ve and 30 (27%) were AQP4 IgG −ve. There was an increase of 48 patients (76%) diagnosed as NMOSD using the new criteria.

Conclusion:

Application of the 2015 criteria led to a rise in diagnosis of NMOSD by 76%. The rise in the AQP4 IgG +ve group contributed 62% and the seronegative group contributed 14%.
‘Because it kind of falls in between, doesn’t it? Like an acute thing and a chronic’: The psychological experience of anaphylaxis in adulthood
Authors: Walklet Elaine , Taylor Charlotte , Bradley Eleanor , Mahoney Berenice , Scurlock-Evans Laura , O’Hickey Steve
Published: August 2016

Anaphylaxis is a serious, rare condition increasing in prevalence. This study explored the psychological experience of adult-onset anaphylaxis from patient, family and staff perspectives. Semi-structured interviews were conducted with 12 participants. Two global themes emerged from thematic analysis: ‘controllability’ (‘an unknown and distressing experience’, ‘the importance of control over triggers’ and ‘responsibility but no control: the impact on others’) and ‘conflict’ (‘rejecting illness identity’, ‘minimisation of risk’, ‘accessing specialist care: running in slow motion’ and ‘patient-centred versus service-centred care’). Findings highlight the importance of perceived control and emphasise the presence of conflict in the experience of this complex, episodic condition.
The role of social capital and community belongingness for exercise adherence: An exploratory study of the CrossFit gym model
Authors: Whiteman-Sandland Jessica , Hawkins Jemma , Clayton Debbie
Published: August 2016

This is the first study to measure the ‘sense of community’ reportedly offered by the CrossFit gym model. A cross-sectional study adapted Social Capital and General Belongingness scales to compare perceptions of a CrossFit gym and a traditional gym. CrossFit gym members reported significantly higher levels of social capital (both bridging and bonding) and community belongingness compared with traditional gym members. However, regression analysis showed neither social capital, community belongingness, nor gym type was an independent predictor of gym attendance. Exercise and health professionals may benefit from evaluating further the ‘sense of community’ offered by gym-based exercise programmes.
Detecting dorsal screw penetration following volar plate fixation of the distal radius – A validation study in a saw bone model
Authors: Poole William EC , Marsland Daniel , Durani Piyush , Hobbs Chris M , Sauvé Philip S
Published: August 2016

Background

The fluoroscopic detection of dorsal screw protrusion following volar locking plate fixation of distal radius fractures remains difficult. The carpal shoot through view has recently been reported to result in a 17% intra-operative screw exchange rate. The aim of the current study was to assess the sensitivity of the carpal shoot through view in comparison to conventional fluoroscopic views for detecting dorsal cortical and distal radio-ulnar joint screw penetration.

Methods

A volar locking plate was applied to a saw bone model and fluoroscopic views taken with the distal screws inserted flush or protruding by two full screw threads. Images were then shown to 10 orthopaedic surgeons who were asked to identify excessively long screws.

Results

The CST view demonstrated the greatest sensitivity for detection of dorsal screw penetration (78%). Its inter-observer reliability was 0.66 (substantial agreement) and intra-observer reliability 0.86 (near perfect agreement). The dorsal skyline had a sensitivity of 51%; the elevated lateral view had a sensitivity of only 16%.

Conclusions

The current study confirms that the elevated lateral view cannot be relied upon alone for the detection of dorsal screw penetration. The CST view is a valid technique demonstrating the greatest sensitivity in comparison to established intra-operative views.
Mechanical characterization and modeling of an innovative composite material for railway applications
Authors: Genovese A , Russo M , Strano S
Published: August 2016

The innovation in the railway industry is focused on the production of lightweight vehicles with high performance, in order to obtain an energy power saving and to satisfy the environmental and global community requests. To pursue this aim, new materials have been increasingly used for vehicle structures. The selection of innovative materials and the definition of the relative properties represent, however, one of the most critical aspects for the design. Several factors, such as technical requirements, strength- and stiffness-to-weight ratios, crash resistance, and cost, are involved in material selection for rail vehicles. In addition, materials have to be chosen in accordance with the reference standards concerning fire resistance. This paper describes the activity carried out in order to acquire the needed information about selected composite materials to be used in the design and validation phases for a structural rail vehicle end and a roof. The material under investigation has been manufactured in order to satisfy the strict railway light metro fire normative. Due to the novelty of the adopted composite materials, a full mechanical characterization of the lamina was needed. The orthotropic material properties were verified and tuned using further tests on laminate and sandwich configurations in order to take into account, also, the influence of manufacturing process parameters. Analytical and numerical approaches have been used to validate and optimize the structural layout. Results of the multistep material characterization, acquired during the above phases, have been used to perform computational analysis in order to further improve the component design.
A numerical illustration of the fusion bonding process
Authors: Jusufi Levent , Körber Roland , Weimer Julia , Lippky Kristian , Kreling Stefan , Dilger Klaus
Published: August 2016

Fusion bonding is an innovative joining technology which enables connecting load-adapted material combinations, such as metals with thermoplastic polymers or fibre-reinforced polymers. The bonding process is facilitated by inductively or conductively heating the metallic joining partner and pressing it onto the plastic joining partner. Due to heat conduction, the plastic melts and wets the metallic joining partner, so that after a holding and cooling phase a bonding results without applying additional joining technologies. The connection quality and bonding strength are linked to the selected process parameters and to achieve the desired outcome, it is crucial to choose the appropriate bonding process parameters. The experimental determination of such is an intricate and complex procedure in terms of costs and time efficiency, and hence simulations have become the preferred method for the dimensioning of joints. This paper discusses the numerical illustration of the fusion bonding process between a metal and a pure plastic hybrid joint. The temperature distribution in the joining partners is a significant process parameter that affects the connection quality and bonding strength. Simulations already exist that can predict such temperature distributions.4,5 This paper builds upon a fully coupled thermal-stress analysis of the fusion bonding process and examines a possible numerical illustration of temperature distribution and mechanical displacements to make predictions about the geometric quality of the joints. For this purpose, the paper sets out to characterize the material behaviour of the polymer and hence generates material core values for the implemented material model in the simulation. The primary focus in this paper is on the temperature and shear rate-dependent viscoelastic behaviour of the plastic throughout the entire joining process temperature range. For the validation of the simulation, a real experiment has been carried out under ideal conditions.
Race, racism, and policing: Responses of Ethiopian Jews in Israel to stigmatization by the police
Authors: Abu Ofir , Yuval Fany , Ben-Porat Guy
Published: August 2016

Immigrants who believe they suffer from stigmatization and discrimination may still demonstrate positive attitudes toward government authorities. We explore this trust–discrimination paradox by examining perceptions about police and policing among Ethiopian Jews in Israel, an immigrant racial minority. Drawing on data collected from focus groups and survey results, we find that levels of trust in the police among Israelis of Ethiopian descent are equal to or higher than among veteran Jewish Israelis. Nevertheless, Ethiopian Israelis also report negative perceptions of the police that are rooted in strong feelings of stigmatization by these government agents. While trust in the police may reflect Ethiopian Jews’ desire for integration, participation, and inclusion as legitimate and equal members of nation and state, we demonstrate that they use various de-stigmatization strategies whose aim is to downplay the importance and depth of their discrimination by the police. These strategies, we argue, allow Ethiopian Israelis to maintain positive attitudes toward the police.
Boundary shifts and vote alignment in Catalonia
Authors: Serrano Ivan , Bonillo Albert
Published: August 2016

This paper analyses the dynamics between ethnic boundaries and electoral alignment in the context of western minority nationalisms by focusing on the Catalan case. In particular, the research explores the changes in boundary shifts at the electoral level, whether they affect differently pro-sovereignty and pro-union parties, and to what extent changes have reinforced the ethnic alignment of vote. Methodologically, the analysis is based on observational data from the elections of 2010 and 2012, which allows control over some of the traditional limits of opinion studies. The results suggest that ethnicity is a dynamic factor that has gained relevance for both sub-state and state-wide parties, and that processes of boundary contraction are not necessarily associated with electoral failure.
Costs of formal and informal care at home for people with dementia: ‘Expert panel’ opinions from staff and informal carers
Authors: Giebel Clarissa M , Davies Susan , Clarkson Paul , Sutcliffe Caroline , Challis David ,   Members of the HoSt-D (Home Support in Dementia) Programme Management Groupl
Published: August 2016

Effective home support in dementia is key in delaying nursing home admission. However, home support is frequently not tailored to the individual needs of people with dementia. Staff allocating home support services may not identify important care needs, which only be recognised by informal carers. The purpose of this study was to explore the balance of informal and formal home support and their associated costs from the perspectives of both informal carers and paid staff. Five case vignettes of people with dementia were designed based on an existing English data set from a European study into transition into long-term care (the RightTimePlaceCare programme), representing 42 per cent of the English sample. In total, 14 informal carers and 14 paid staff were consulted in separate groups, as expert panels, regarding their recommendations for home care services for each vignette. Care recommendations of carers and staff were costed based on nationally available unit costs and compared. Informal carers allocated fewer hours of care than staff. Personal and domestic home care and day care centres were the most frequently recommended formal services by both groups, and some vignettes of people with dementia were recommended for care home admission. The ratio of costs of informal versus formal support was relatively equal for paid staff, yet unbalanced from the perspectives of informal carers with a greater proportion of formal care costs. Recommendations from this study can help shape dementia care to be more tailored to the individual needs of people with dementia and their carers.
The role of poetics in architectural lighting design
Authors: Dugar AM
Published: August 2016

Architectural lighting design is generally believed to have visual and psychological consequences on humans, and has been investigated either as an artistic or a scientific endeavour. This paper explores the possibility that these two viewpoints are not mutually exclusive with a poetic approach. It builds upon two arguments: the first is that poetry, being an inherently compositional system like language, impacts the perceived meaning of lit environments; the second is that humans seek qualities with experiential richness when interacting with lit environments, which is very much aligned with poetry. This reasoning is supplemented by reflections on the poetic possibilities within realised projects used as simple artistic and scientific case studies to demonstrate this complex visual and psychological interplay. Opinions from academics and professionals from the field of architectural lighting design are sought on these poetic possibilities, the appropriateness of these realised projects in expressing their respective qualities, and on the role of poetics in architectural lighting design in general.
Endovascular Aneurysm Sealing
Authors: Thompson Matt M. , Heyligers Jan M. , Hayes Paul D. , Reijnen Michel M. P. J. , Böckler Dittmar , Schelzig Hubert , de Vries Jean-Paul P. M. , Krievins Dainis , Holden Andrew ,   for the EVAS FORWARD Global Registry Investigators
Published: August 2016

Purpose: To report the early and 12-month results of a global registry of patients treated with endovascular aneurysm sealing (EVAS) for abdominal aortic aneurysms (AAAs). Methods: The EVAS FORWARD Global Registry was a postmarket, multicenter, open-label, single-arm registry that enrolled 277 patients (mean age 75 years; 228 men) treated with the Nellix EVAS system for nonruptured AAAs at 18 sites over a 1-year period. The cohort had challenging aortic anatomy, with 17% having a proximal aortic neck length <10 mm, 8% a neck angulation >60°, and 20% an iliac diameter >25 mm. Baseline and follow-up computed tomography images were assessed by an independent core laboratory, and major adverse events were reviewed by an independent safety committee. Results: Three patients died within 30 days of the procedure (none device-related). There were 13 endoleaks recorded in this time frame: 8 type Ia, 1 type Ib, and 5 type II. Root cause analysis demonstrated that the majority of type Ia endoleaks were due to technical error (low device placement and underfilling of the endobags). Between 30 days and 1 year, there were 4 new type Ia endoleaks; all were treated. There was also 1 type III endoleak between a Nellix device and a distal extension limb. At 1 year, the persistent endoleak rate was 0.7% (1 type Ia and 1 type II). The Kaplan-Meier estimates of freedom from types I and II endoleak at 12-month follow-up were 96% and 98%, respectively. The estimate of freedom from open conversion (n=7) was 98% at 12 months and the rate of freedom from any reintervention was 92%. The need for secondary intervention was associated with aortic morphology; for patients meeting the requirements of the instructions for use (IFU), the freedom from reintervention at 12 months was 98% compared with 86% when the implant was outside the IFU (p=0.009). At 1 year, the estimates of freedom from aortic-related and all-cause mortality were 98% and 95%, respectively. Conclusion: The EVAS FORWARD Global Registry documents the 12-month outcome of EVAS in an unselected group of patients with challenging aortic morphology. The results at present appear acceptable with regard to perioperative outcomes and complications. The type II endoleak rate is low. The place of EVAS in the armamentarium of techniques to treat AAAs will be defined by durability data in the longer term.
Osteoporosis in Pediatric Liver Transplantation
Authors: Faraj Walid , El Nounou Ghina , Abou Al Naaj Abdallah , Nakhoul Nancy , Haydar Ali , Khalife Mohammad
Published: August 2016

Liver transplantation provides an important, often life-saving treatment for end-stage liver disease. Osteoporosis post-liver transplantation has been described in adults; however, this has not been described in the pediatric population to date. We present a case of a 13-year-old female patient who underwent an orthotopic liver transplant for cryptogenic liver cirrhosis. Her immunosuppressants were tacrolimus and prednisone. Four months posttransplant, she started complaining of bilateral lower limb pain and limping while walking, progressing to a point where she was almost immobile. Magnetic resonance imagining of the pelvis showed bilateral avascular necrosis involving the weight-bearing surfaces of both femoral heads, in addition to the extensive edema involving both hip joints. Bone mineral densitometry was below normal for her age at the hip and forearm. She was started on high-dose calcium and vitamin D supplement, as well as zoledronic acid with a remarkable symptomatic and functional improvement.
Vitamin D Treatment Effect on Serum Endocan and High-Sensitivity C-Reactive Protein Levels in Renal Transplant Patients
Authors: Atis Omer , Keles Mustafa , Cankaya Erdem , Dogan Hasan , Aksoy Hulya , Akcay Fatih
Published: August 2016

Context:

Endocan is a marker showing endothelial dysfunction and inflammation. Significantly increased endocan levels have been observed in serum of patients with sepsis and cancer.

Objective:

Our aim was to investigate the relationship between vitamin D treatment and serum endocan and high-sensitivity C-reactive protein (hs-CRP) levels as inflammatory markers in transplant patients.

Design:

Prospective.

Setting:

Nephrology clinic.

Patients:

Thirty-eight renal transplant patients with serum 25-hydroxy-vitamin D (25-OH-vitamin D) levels below 20 ng/mL and transplanted at least 12 months.

Intervention:

One-time oral dose of 300 000 IU vitamin D3.

Main Outcome Measures:

Before and after vitamin D treatment, serum endocan, hs-CRP, calcium, phosphorus, and parathyroid hormone (PTH) levels were measured.

Results:

Median serum endocan and PTH values before vitamin D were significantly higher than those of after treatment values ( P = .001 and P < .001, respectively). On the other hand, serum total calcium and phosphorus levels before vitamin D treatment were lower than the values obtained after vitamin D treatment ( P = .0013 and P < .001, respectively). Serum hs-CRP was lower after vitamin D therapy than before, but the difference was not statistically significant ( P = .06). A moderate negative correlation was determined between endocan and 25-OH-vitamin D levels after treatment with vitamin D ( r = −.36, P = .02).

Conclusion:

This study has revealed that vitamin D treatment reduced markers of endothelial dysfunction in patients with renal transplantation and vitamin D deficiency.
Preclinical PET Neuroimaging of [11C]Bexarotene
Authors: Rotstein Benjamin H. , Placzek Michael S. , Krishnan Hema S. , Pekošak Aleksandra , Collier Thomas Lee , Wang Changning , Liang Steven H. , Burstein Ethan S. , Hooker Jacob M. , Vasdev Neil
Published: August 2016

Activation of retinoid X receptors (RXRs) has been proposed as a therapeutic mechanism for the treatment of neurodegeneration, including Alzheimer's and Parkinson's diseases. We previously reported radiolabeling of a Food and Drug Administration-approved RXR agonist, bexarotene, by copper-mediated [11C]CO2 fixation and preliminary positron emission tomography (PET) neuroimaging that demonstrated brain permeability in nonhuman primate with regional binding distribution consistent with RXRs. In this study, the brain uptake and saturability of [11C]bexarotene were studied in rats and nonhuman primates by PET imaging under baseline and greater target occupancy conditions. [11C]Bexarotene displays a high proportion of nonsaturable uptake in the brain and is unsuitable for RXR occupancy measurements in the central nervous system.
An Investigation Into Mentoring Practices of Faculty Who Mentor Undergraduate Researchers at a Hispanic Serving Institution
Authors: Estepp Christopher M. , Velasco Joseph G. , Culbertson Avery L. , Conner Nathan W.
Published: August 2016

Research has shown the benefits of undergraduate research; however, few studies have examined mentors of undergraduate researchers. The purpose of this study was to investigate the practices of mentors who have successfully mentored Hispanic undergraduate researchers. Findings from this study suggested that mentors should focus on interacting with students, listen to and understand students’ interests, be organized, require students to be responsible, and monitor students’ work. Recommendations for practice and research have been provided.
The Challenge of Community Representation
Authors: Lawrence Carlton , Stewart Kearsley
Published: August 2016

Although community advisory boards (CABs) are widely used in clinical research, there is limited data regarding their composition and structure, especially in Africa. Our research provides the first qualitative study of the membership practices, selection methods, and qualifications of the six major HIV research centers that comprise the Ugandan National CAB Network (UNCN). Researchers conducted interviews ( n = 45) with CAB members and research liaisons at each of the sites. While selection practices and demographics varied between the sites, all six CABs exclusively followed a broad community membership model. Results suggest successful CABs are context dependent and thus distinct guidelines may be needed based on variables including CAB funding level, representation model, and research focus.
Dynamic modeling method for air bearings in ultra-precision positioning stages
Authors: Bao Xiulan , Mao Jincheng
Published: August 2016

Air bearings have been widely used in ultra-precision positioning stages due to the property of nearly zero friction or wear. Small vibration of the bearing reduces the overall moving and positioning precision of the stage and hampers its applications in fabrication facilities requiring nanometer moving and positioning precision. In order to improve system precision, knowledge of the dynamic characteristics of air bearings is the first and crucial step. However, it is still a challenge to set up an accurate dynamic model for air bearings due to the system complexity. In this article, a novel method for the dynamic modeling of air bearing is proposed, which takes into account the dynamics in both the moving direction and the supporting direction. An ultra-precision positioning dual stage is investigated using the proposed dynamic modeling method. This stage has two sets of air bearings and can be used in integrated circuit fabrication equipments. Moreover, dynamic behaviors of the ultra-precision positioning dual stage are studied and compared with experimental results to validate the effectiveness and accuracy of the proposed method.
Quality assurance testing of transoesophageal echocardiography probes
Authors: McLeod Christopher , McNeill Kirsty , McBride Karne , Inglis Scott , Pye Stephen D
Published: August 2016

Introduction

In response to an ultrasound imaging issue with transoesophageal echocardiography probes, a testing protocol was developed to check features pertinent to the operation of these probes. The imaging problem was detected in multiple probes of the same make and model.

Methods

Over a two-year period, a series of 26 probes of this model were tested at acceptance, then three to six months later before being replaced due to a defect. A range of visual, mechanical and electrical tests were performed. Image tests comprised low-contrast penetration measurements and a comparison of phantom images at regular intervals to highlight artefacts in both B-mode and colour Doppler imaging.

Results

Of the 26 defective probes replaced, 7 suffered mechanical/electrical problems, 5 of which prevented imaging results being obtained. Low-contrast penetration reduction of greater than 5% occurred in 14 probes. B-mode artefacts were observed on 12 probes and Doppler noise artefacts on 6 probes. No faults were found on five probes. The manufacturer addressed the imaging problem identified and of the seven subsequent probes supplied, only one suffered an imaging fault.

Conclusions

The implementation of a quality assurance protocol for transoesophageal echocardiography probes resulted in cost savings on replacements/repairs. When provided with the evidence gathered, the manufacturer supplied 23 probes under warranty or as loan equipment. The regular testing of the probes substantially reduced the impact of downtime and poor diagnosis from this equipment on the clinical service.
Cognitive deficits in problematic drinkers with and without mild to borderline intellectual disability
Authors: van Duijvenbode Neomi , Didden Robert , VanDerNagel Joanne EL , Korzilius Hubert PLM , Engels Rutger CME
Published: August 2016

We examined cognitive deficits in problematic drinkers with and without mild to borderline intellectual disability (MBID). Problematic drinkers were expected to show a significantly lower estimated performance IQ (PIQ), but not a lower estimated verbal IQ (VIQ), compared to light drinkers. Participants ( N = 474) were divided into four groups based on IQ and severity of alcohol use-related problems. IQ was estimated using (a short form of) the Wechsler Adult Intelligence Scale third edition. Severity of alcohol use-related problems was assessed using the Alcohol Use Disorder Identification Test. Overall, there were no significant differences between light and problematic drinkers on estimated VIQ. Within the group without MBID, estimated PIQ was significantly lower. Estimated PIQ was not lower in problematic drinkers with MBID compared to light drinkers with MBID. The results are indicative of cognitive deficits in problematic drinkers without MBID. Screening for cognitive deficits with additional instruments is advised.
A Shared Rhetoric: The Western Front in 1914/15 as reported by Harry Gullett and Philip Gibbs
Authors: Kerby Martin
Published: August 2016

The newspaper articles written by the Australian Harry Gullett and his English counterpart Philip Gibbs during the opening months of the First World War provide important insights into the nature of war reporting, propaganda, censorship, and the relationship between the press and the military. Despite differences in background and temperament, their reports, which were written prior to official accreditation, were remarkably similar in tone and content for Gullett and Gibbs shared the belief that war was a regenerative force that would purify and strengthen a degenerate pre-war Britain. Both writers adopted a rhetoric in their initial wartime correspondence that emphasized traditional martial and patriotic values that they believed were an antidote to the weakness and disunity of a pre-war Britain beset by industrial, social and political upheaval. Battles would therefore be best presented as extended heroic narratives in which there was order, honour and greatness. This approach exerted an influence as pervasive as censorship itself.
Pain perception in healthy volunteers: effect of repeated exposure to experimental systemic inflammation
Authors: Janum Susanne , Nielsen Signe T , Werner Mads U , Mehlsen Jesper , Kehlet Henrik , Møller Kirsten
Published: August 2016

We aimed to study the relationship between pain perception and cytokine release during systemic inflammation. We present a randomized crossover trial in healthy volunteers ( n = 17) in 37 individual trials. Systemic inflammation was induced by an i.v. bolus of Escherichia coli LPS (2 ng/kg) on two separate trial days, with or without a nicotine patch applied 10 h previously. Pain perception at baseline, and 2 and 6 h after LPS was assessed by pressure algometry and tonic heat stimulation at an increasing temperature (45–48℃) during both trials. Compared with baseline, pain pressure threshold was reduced 2 and 6 h after LPS, while heat pain perception was accentuated at all testing temperatures after 2 but not 6 h. The magnitude of changes in pain perception did not correlate to cytokine release. No effect of transdermal nicotine or training status was observed. In conclusion, LPS administration in healthy human volunteers leads to reduction in pain pressure threshold and an increase in pain perception to heat stimuli, supporting a relationship between acute systemic inflammation and pain perception.
Contribution of FcɛRI-associated vesicles to mast cell–macrophage communication following Francisella tularensis infection
Authors: Rodriguez Annette R , Yu Jieh-Juen , Navara Christopher , Chambers James P , Guentzel M Neal , Arulanandam Bernard P
Published: August 2016

Understanding innate immune intercellular communication following microbial infection remains a key biological issue. Using live cell imaging, we demonstrate that mast cells actively extend cellular projections to sample the macrophage periphery during Francisella tularensis LVS infection. Mast cell MHCIIhi expression was elevated from less than 1% to 13% during LVS infection. Direct contact during co-culture with macrophages further increased mast cell MHCIIhi expression to approximately 87%. Confocal analyses of the cellular perimeter revealed mast cell caspase-1 was localized in close proximity with FcɛRI in uninfected mast cells, and repositioned to clustered regions upon LVS infection. Importantly, mast cell FcɛRI-encompassed vesicles are transferred to macrophages by trogocytosis, and macrophage caspase-1 expression is further up-regulated upon direct contact with mast cells. Our study reveals direct cellular interactions between innate cells that may impact the function of caspase-1, a known sensor of microbial danger and requirement for innate defense against many pathogenic microbes including F. tularensis.
Sunitinib in the treatment of metastatic renal cell carcinoma
Authors: Schmid Thomas A. , Gore Martin E.
Published: August 2016

Sunitinib is an oral multi-targeted tyrosine kinase inhibitor (TKI) that targets various receptors, including vascular endothelial growth factor receptors (VEGFRs). Sunitinib received approval in 2006 and became a standard treatment option in the first-line treatment of metastatic renal cell cancer (mRCC) after a phase III trial showed superiority compared with interferon alpha (IFN-α). Sunitinib has also shown activity in second-line treatment in several trials. Most of the combination trials with sunitinib with various agents have led to considerable toxicity without improving efficacy. Sunitinib alone causes significant side effects and has a distinct profile with diarrhoea, hypertension, skin effects hypothyroidism, fatigue and nausea of special interest. The recommended dose of sunitinib in mRCC is 50 mg orally daily for 4 weeks, followed by 2 weeks off treatment (4/2 schedule). An alternative 2 weeks on, 1 week off schedule (2/1 schedule) seems to be of similar efficacy and better tolerability and could be more widely used in the future. An intermittent treatment strategy with a stop in remission and re-induction after progression showed efficacy in smaller trials and is currently being evaluated in a phase III trial. Direct comparison of sunitinib with pazopanib in first-line treatment showed a similar efficacy for both TKIs with a distinct toxicity profile. Data from two phase II trials showed that sunitinib has also activity in non-clear cell cancer and is an option due to a lack of better alternatives. Currently, after immune checkpoint inhibitors have shown very promising results in the second-line treatment of RCC, they are being tested in a number of phase III trials in the first-line setting. The future will show the position of sunitinib in the first-line treatment of RCC in the era of the immune checkpoint inhibitors.
Comparison of an Electronic Glycemic Management System Versus Provider-Managed Subcutaneous Basal Bolus Insulin Therapy in the Hospital Setting
Authors: Aloi Joseph , Bode Bruce W. , Ullal Jagdeesh , Chidester Paul , McFarland Raymie S. , Bedingfield Amy E. , Mabrey Melanie , Booth Robby , Mumpower April , Wallia Amisha
Published: August 2016

Background:

American Diabetes Association (ADA) guidelines recommend a basal bolus correction insulin regimen as the preferred method of treatment for non–critically ill hospitalized patients. However, achieving ADA glucose targets safely, without hypoglycemia, is challenging. In this study we evaluated the safety and efficacy of basal bolus subcutaneous (SubQ) insulin therapy managed by providers compared to a nurse-directed Electronic Glycemic Management System (eGMS).

Method:

This retrospective crossover study evaluated 993 non-ICU patients treated with subcutaneous basal bolus insulin therapy managed by a provider compared to an eGMS. Analysis compared therapy outcomes before Glucommander (BGM), during Glucommander (DGM), and after Glucommander (AGM) for all patients. The blood glucose (BG) target was set at 140-180 mg/dL for all groups. The safety of each was evaluated by the following: (1) BG averages, (2) hypoglycemic events <40 and <70 mg/dL, and (3) percentage of BG in target.

Result:

Percentage of BG in target was BGM 47%, DGM 62%, and AGM 36%. Patients’ BGM BG average was 195 mg/dL, DGM BG average was 169 mg/dL, and AGM BG average was 174 mg/dL. Percentage of hypoglycemic events <70 mg/dL was 2.6% BGM, 1.9% DGM, and 2.8% AGM treatment.

Conclusion:

Patients using eGMS in the DGM group achieved improved glycemic control with lower incidence of hypoglycemia (<40 mg/dL and <70 mg/dl) compared to both BGM and AGM management with standard treatment. These results suggest that an eGMS can safely maintain glucose control with less hypoglycemia than basal bolus treatment managed by a provider.
How Beauty Determines Gaze! Facial Attractiveness and Gaze Duration in Images of Real World Scenes
Authors: Leder Helmut , Mitrovic Aleksandra , Goller Jürgen
Published: August 2016

We showed that the looking time spent on faces is a valid covariate of beauty by testing the relation between facial attractiveness and gaze behavior. We presented natural scenes which always pictured two people, encompassing a wide range of facial attractiveness. Employing measurements of eye movements in a free viewing paradigm, we found a linear relation between facial attractiveness and gaze behavior: The more attractive the face, the longer and the more often it was looked at. In line with evolutionary approaches, the positive relation was particularly pronounced when participants viewed other sex faces.
The influence of caregivers and behavioral and psychological symptoms on nursing home placement of persons with Alzheimer’s disease: A matched case–control study
Authors: Porter Candace N , Miller Margaret C , Lane Marcia , Cornman Carol , Sarsour Khaled , Kahle-Wrobleski Kristin
Published: August 2016

Objectives:

Behavioral and psychological symptoms of dementia in individuals with Alzheimer’s disease and caregiver characteristics may influence the decision to provide care at home or in a nursing home, though few studies examine this association near the actual time of nursing home placement. Using a matched case–control design, this study investigates the association between (1) total Neuropsychiatric Inventory score, (2) the Neuropsychiatric Inventory-4 (an agitation/aggression subscale), and (3) individual domains of the Neuropsychiatric Inventory and nursing home placement.

Methods:

Data from the South Carolina Alzheimer’s disease Registry provides an opportunity to expand the literature by looking at cases at the time of nursing home care eligibility/placement and allowing for propensity-score-matched controls. Cases (n = 352) entered a nursing home within 6 months of study initiation; controls (n = 289) remained in the community. Registry data were combined with caregiver survey data, including the Neuropsychiatric Inventory. Conditional logistic regression was applied.

Results:

A 10% increase in the Neuropsychiatric Inventory score implied a 30% increase in odds of nursing home admission (odds ratio: 1.30; 95% confidence interval: 1.14–1.50), having married or male caregivers predicted nursing home placement. Cases versus controls were significantly more likely to have behavioral and psychological symptoms of dementia related to agitation/aggression 1 month prior to nursing home admission.

Conclusion:

Interventions targeting behavioral and psychological symptoms of dementia without available effective interventions in individuals with Alzheimer’s disease and caregiver support services are necessary to prevent or delay nursing home admission.
Chaplains' perspectives on their work in Tasmanian government schools
Authors: Rayner Christopher S , Swabey Karen J
Published: August 2016

School chaplaincy services aim to promote student and school community well-being. Given the community interest in chaplaincy services in government schools, it is important that research inform future developments to maximize the potential benefits of chaplaincy services to schools. In this study, 68 chaplains in the Australian state of Tasmania described and shared views on their work through the completion of an anonymous online survey. The findings present a picture of the nature, strengths and challenges of chaplaincy in Tasmanian government schools from the perspective of chaplains themselves. The results are summarized, several implications are identified, and directions for future research are explored.
An Update on Travel Vaccines and Issues in Travel and International Medicine
Authors: Rogers Bonnie , Bunn William B. , Connor Bradley A.
Published: August 2016

The fields of travel and international medicine are rapidly changing and growing. The role of occupational and travel health nurses is expanding and should be a focus for the future. At the American Association of Occupational Health Nurses Annual meeting on March 24, 2015, in Boston, five presentations were included in the session, An Update on Travel Vaccines and Issues in Travel and International Medicine. This article summarizes three of the presentations and includes a portion of the information generated by the Centers for Disease Control and Prevention (CDC) included in the fourth presentation. The first section focuses on the Essential Elements of Travel Medicine Programs including the pre-travel care assessment, trip research and risk identification, medication intervention review, non-pharmaceutical and prevention strategies, and post-travel care. The next section is an overview of key issues for business travelers. The growth in the number of international business travelers and unique aspects of business travel are emphasized in a comprehensive travel health program. This section also includes a discussion of expatriates and their special risks identified in recent literature (e.g., an assessment of the significant costs of health events and productivity losses by both business travelers and expatriates). The final section offers a specific example of a vaccine-preventable disease, namely, Japanese encephalitis (JE) virus, and needed changes in JE vaccine recommendations.