bluuebunny/crossref_metadata_2025 huggingface dataset:
CLINICAL EFFECTS OF TRAMIPROSATE IN APOE4/4 HOMOZYGOUS PATIENTS WITH MILD ALZHEIMER’S DISEASE SUGGEST DISEASE MODIFICATION POTENTIAL
Authors: Abushakra S. , Porsteinsson A. , Scheltens P. , Sadowsky C. , Vellas B. , Cummings J. , Gauthier S. , Hey J.A. , Power A. , Wang P. , Shen L. , Tolar M.
Published: November 2021

Background: Alzheimer’s Disease (AD) patients homozygous for the APOE4 allele (APOE4/4) have a distinct clinical and biological phenotype with high levels of beta amyloid (Aβ) pathology and toxic Aβ oligomers. Tramiprosate, an oral agent that inhibits Aβ monomer aggregation into toxic oligomers, was evaluated in two Phase 3 Mild to Moderate AD studies which did not show efficacy in the overall population. Re-analyses of these trials showed the most consistent clinical benefits in APOE4/4 patients. We analyzed efficacy in the APOE4/4 patients with Mild disease. Objectives: To determine the optimal stage of AD for future trials in APOE4/4 homozygotes. Design: Two randomized, double-blind, placebo-controlled parallel-arm multi-center studies of 78-weeks duration. Setting: Academic Alzheimer’s disease centers, community-based memory clinics, and neuropsychiatric research sites. Participants: Participants included 2,025 AD patients with MMSE 16-26. Approximately 13-15% had APOE4/4 genotype (N= 147 and 110 per study), mean age 71.1 years, 56% females. Almost all were on stable symptomatic drugs. Intervention: Randomized subjects received oral placebo, 100mg BID, or 150mg BID of tramiprosate. Measurements: Co-primary outcomes were change from baseline in the ADAS-cog11 and CDR-SB. Disability assessment for dementia (DAD) was a secondary outcome. Results: In APOE4/4 homozygotes receiving 150mg BID tramiprosate, efficacy in the traditional Mild AD patients (MMSE 20-26) was higher than the overall group (MMSE 16-26) and efficacy in the Mild patients (MMSE 22-26) was highest. Tramiprosate benefits compared to placebo on ADAS-cog, CDR-SB, and DAD were 125%, 81% and 71%, respectively (p<0.02). The Mild subgroup (MMSE 22-26) showed cognitive stabilization with no decline over 78 weeks, both ADAS-cog and DAD effects increased over time. Tramiprosate safety in APOE4/4 patients was favorable. Most common adverse events were nausea, vomiting, depression and decreased weight. Conclusions: The Mild subgroup of APOE4/4 AD patients (MMSE 22-26) showed larger benefits on the high dose of tramiprosate than the overall Mild and Moderate group. Consistent with its preclinical effects on Aβ oligomers, tramiprosate seemed to stabilize cognitive performance, supporting its disease modification potential. Confirmatory studies using ALZ-801, an improved pro-drug formulation of tramiprosate, will target APOE4/4 patients with Mild AD.
Social pedagogy versus social work in a Swedish context
Authors: Cedersund Elisabet , Eriksson Lisbeth , Jansson Bibbi Ringsby , Svensson Lars A.
Published: November 2021

In Sweden there are several different professions that work within the welfare sector. Two of these are social pedagogues and socionoms. This article examines the similarities and differences between these professional fields by exploring four areas in more detail: education, the history of ideas and theory, research and practice. The results show that there are not only many differences but also some similarities. In practical work, social pedagogues and socionoms often work side by side and perform similar tasks. They are located in the same areas and often use the same methods. When it comes to the differences in educational history and current educations, they are large although they can also be found in, for example, the history of ideas. Furthermore, research in the various areas differs. In social pedagogy the interest has to a greater extent been focused on an understanding of the discipline through studies of the history of ideas, while in social work today one often focuses on studies of professional methods. Today’s challenges in the welfare sector require new knowledge, ways of thinking and understanding. Here, social pedagogy with its philosophical roots and humanistic values can play an important role.
Diffuse Attenuation Coefficient (Kd) from ICESat-2 ATLAS Spaceborne Lidar Using Random-Forest Regression
Authors: Corcoran Forrest , Parrish Christopher E.
Published: November 2021

This study investigates a new method for measuring water turbidity—specifically, the diffuse attenuation coefficient of downwelling irradiance Kd —using data from a spaceborne, green-wavelength lidar aboard the National Aeronautics and Space Administration's ICESat-2
satellite. The method enables us to fill nearshore data voids in existing Kd data sets and provides a more direct measurement approach than methods based on passive multispectral satellite imagery. Furthermore, in contrast to other lidar-based methods, it does not rely on extensive signal
processing or the availability of the system impulse response function, and it is designed to be applied globally rather than at a specific geographic location. The model was tested using Kd measurements from the National Oceanic and Atmospheric Administration's Visible Infrared Imaging Radiometer
Suite sensor at 94 coastal sites spanning the globe, with Kd values ranging from 0.05 to 3.6 m –1 . The results demonstrate the efficacy of the approach and serve as a benchmark for future machine-learning regression studies of turbidity using ICESat-2.
A Chronic Condition E-Learning Module for School Nurses to Train Afterschool Teachers and Staff
Authors: Welker Kristen , Cox Carol , Bylina Haley , Baer Hailee , Duessel Shelby
Published: November 2021

This case presents the design and assessment (at the Interaction level) of a student chronic condition e-learning module. The module is to be used by school nurses as a traditional presentation aid/slideshow to support their on-ground trainings for afterschool staff on how to manage students with chronic health conditions participating in afterschool programs. However, it also serves as an interactive, one-stop-shop for more detailed education and information on the conditions (e.g., additional prevention and treatment materials, step-by-step emergency actions for staff during and after school, resources for more training and education). Trained teachers and staff can then spend post-training time at home reading and interacting with module materials to go more in-depth on the material that the school nurses presented. Also, the module was created to be viewed on mobile devices and tablets that afterschool staff would keep with them, possibly referring to them in real-time for prevention or emergency actions.
Contenidos escolares en ciencias naturales desde el currículo oficial de Colombia
Authors: Cárdenas-Nava Ana María , Martínez-Rivera Carmen Alicia
Published: November 2021

Este artículo da cuenta de los contenidos escolares (tipos y niveles de organización) que subyacen en las orientaciones curriculares expedidas por el Ministerio de Educación Nacional de Colombia para el área de Ciencias Naturales, estudio que se adelantó en el Doctorado Interinstitucional en Educación. La investigación se enmarca en el enfoque cualitativo, desde una perspectiva interpretativa y asume como método el estudio de caso. Se examinaron los Lineamientos Curriculares, los Estándares Básicos de Competencias y los Derechos Básicos del Aprendizaje, y se realizó una entrevista semiestructurada a un coautor por cada orientación. Los datos fueron tratados a través del análisis de contenido, con apoyo del software Atlas.ti. Se destacan como resultados los diferentes tipos de contenidos escolares conceptuales, procedimentales y actitudinales, y se evidencian algunas articulaciones entre dichos contenidos y las propuestas de organización, como la formulación de niveles de complejidad y los ejes articuladores. Se concluye que los tipos de contenidos escolares están vinculados de manera directa con una visión disciplinar (nivel instruccional-cientificista); en cambio, para la organización de los contenidos escolares se propone una construcción pedagógica y didáctica propia (nivel integrador-transformador).
Diseño de unidades STEM integradas: una propuesta para responder a los desafíos del aula multigrado
Authors: Castro-Inostroza Angela , Jiménez-Villarroel Rodrigo , Medina-Paredes Jhonny
Published: November 2021

La enseñanza multigrado tiene el desafío de garantizar oportunidades de acceso a experiencias de aprendizaje auténticas y relevantes, tal como aquellas a las que pueden optar los alumnos en contextos tradicionales de escolaridad. En este artículo de reflexión argumentamos que una forma de hacer frente a este y otros desafíos de la enseñanza en contextos multigrado es implementar la educación STEM, apoyando y alentando a los docentes a diseñar unidades curriculares STEM integradas. Comenzamos este artículo compartiendo algunas consideraciones sobre los principales desafíos de la educación multigrado y el potencial que tiene la educación STEM integrada para abordarlos. A continuación, analizamos el propósito de diversas estrategias de enseñanza en contextos multigrado reportadas en la literatura y exponemos los principales desafíos asociados al diseño de unidades STEM integradas, identificando aspectos clave que se deben considerar para desarrollar este tipo de propuestas en tales contextos. Finalmente, sobre la base de los aspectos identificados, ofrecemos una alternativa para acercar la educación STEM al aula multigrado, proponiendo un marco que oriente el diseño de unidades STEM integradas en estos contextos.
Tecnologías de energías renovables (TER) desde el compromiso público
Authors: Gallego-Torres Adriana-Patricia , Ballesteros-Ballesteros Vladimir-Alfonso
Published: November 2021

Este trabajo presenta una revisión extensa acerca de la importancia de las posturas ciudadanas en la implementación de las tecnologías de energías renovables (TER). En las últimas décadas la educación ha intentado comprender desde el compromiso público la aceptación social de las tecnologías de energías renovables y la participación de las comunidades en los procesos de toma de decisiones relacionados con la transición hacia la implementación de energías limpias. En este sentido, el presente trabajo hace una reflexión teórica sobre el compromiso público, la aceptación e implementación de modelos de tecnologías en energías renovables y la participación ciudadana.
A Study on Community Leisure and Recreation Activities Chendor, Sungai Karang Sub-District, Kuantan
Authors: Rahman Norsafriman Abdul , Latif Rohaizah Abdul , Sulaiman Fatimah
Published: November 2021

The purpose of the study were to explore and examined the resources available in the Chendor area and to determine whether the community leisure and recreational activities could be developed as tourism products. The study had also determined the tourism products’ conditions and viability, the extent of community involvement required, and whether the tourism products development could directly benefit the community without causing adverse impact on the resources. The ethnography approach was adopted where the primary data were collection via observations and interviews conducted at the site during a 2-week period. The observational process was aided by using checklists of the natural resources, cultural resources, community resources, site resources, tourism services and facility, and environment assessment. Open-ended questionnaires were used as the basis for interviewing selected community members and community leaders. Secondary data were used to enhance the findings from the primary data. Chendor had three tourism products which were watching turtle coming ashore, visitation to the turtle sanctuary, and wood carving; which had been developed, but could be further enhanced to attract more international tourists. However, accommodation facilities needed to be provided to encourage tourists to stay at Chendor so that they could contribute more income for the community. The issue on the area carrying capacity would need to be seriously examined so to conserve the main attraction of the area which was watching the turtle coming ashore to lay eggs and the turtle sanctuary.
Green Transformational Leadership to Build Value, Innovation and Competitive Advantage in Era Digital
Authors: Suparna Gede , Yasa Ni Nyoman Kerti , Giantari I Gusti Ayu Ketut , Sukaatmadja I Putu Gde , Setini Made
Published: November 2021

This study develops an exploration system that connections Green groundbreaking initiative, green worth advancement improvement, and the upper hand in business supportability. This investigation depicts the impact of the groundbreaking green initiative on the maintainable upper hand and talks about esteem development's interceding impact utilizing an underlying condition model (SEM). The examination results tracked down that green groundbreaking authority has a critical constructive outcome on esteem development and the reasonable upper hand. Besides, the investigation tracked down that groundbreaking green administration on the upper hand was incompletely interceded by esteem advancement. Industrialization and globalization have had a positive impact on economic growth, but on the other hand to be a major cause of environmental violations in this modern world, so most companies required to focus on environmentally friendly concepts to achieve sustainable company performance, so that green transformational leadership provides positive development in sustaining competitive advantage through the creation of green innovation values.
A Study on Supply Chain Management and Characteristics of Container Port Operation Efficiency in Vietnam by Emerging Measure Tools
Authors: Pham Van Tai
Published: November 2021

Seaport services are an important and decisive focal point in improving the logistics process's efficiency. Several prerequisites such as productivity and customer satisfaction are considered to be mandatory measures of port performance. Therefore, the determination of the characteristics and the evaluation of the effects of those important factors on the efficient operation of the port has always attracted much attention from scholars. This work aims to identify and evaluate the factors of port characteristics affecting container port operation efficiency. As a result, the port operation is more efficient. The competitiveness is enhanced in the context of fierce competition in seaport business in general and container ports and container terminals in particular. With qualitative methods combined with quantitative, using a 5-point width scale, analysis according to the linear structure model (SEM) with 530 samples. The research results show that 6 factors belong to the characteristics of container ports: infrastructure, location, inland connectivity, dynamism, logistics services, attractiveness impact the performance of container port operation. As meaningful, the study can bring benefits to port and container terminal businesses to build the right policies and decisions in competitiveness enhancement and help policymakers and port planning have an overview when implementing the plan.
Creation of the System for Management of Technology-Related Risks at the Enterprise
Authors: Latkin Matvey A. , Radoutskiy Vladimir Yu. , Kemenov Sergey А. , Stepanova Maria N.
Published: November 2021

A problem of creating a technology-related risks management system at an enterprise has been considered. On the basis of applying system approach and system modeling, a set of interrelated structural and process models was built for using them in the technology-related risks management system of an enterprise. By means of the suggested models and matrix projections between them, we can carry out the organizational analysis of a technology-related risks management system of an enterprise, which allows determining the functional workload and responsibility of structural elements of the created system. The calculation procedure of personnel in accordance with the established posts list has been developed for the technology-related risks management system of an enterprise, which would allow cutting administrative costs for the functions of risk managers.
Consumer Buying Behaviour During COVID-19
Authors: Anifa Mansurali , Ramakrishnan Swamynathan , Jeyanthi P. Mary
Published: November 2021

A pandemic like COVID-19 that has the capacity to turn any economy upside down will always have a significant influence on the social Behavior and habits of population all over the world. COVID-19 pandemic is a historic challenge for any economy to overcome as they have no prior preparation. Lack of testing kits, insufficient ventilators and community spread has forced countries to impose indefinite shutdown that has made major markets to suffer. The goal of this paper is to study the buying behavior of consumers during covid-19. This paper also focuses on the factors that influence consumer’s behavior and perceptions during the pandemic. A quantitative view has been adopted to achieve the objectives of the study. With limited online buying options and higher risk of getting infected with brick & mortar shopping, it is important to understand consumer buying Behavior that can help policy makers, manufacturers, and companies to better deal with similar crisis in the future.
Optimized Content Adaptive Approach for Image Detailed Enhancement to Reduce Color Distortion
Authors: Dohan Mohammed Iqbal , Mohammed Nora Ahmed , Mohammed Mohammed Rajeh
Published: November 2021

Digital imaging has significantly influenced the outcome of research in various disciplines. For example, artificial intelligence and robotics, biometric security, multimedia and image processing, etc. Technically, image processing and the Human Visual System (HVS) relies heavily on image enhancement to improve the content of the image. One of the biggest challenges in image processing is detail enhancement due to halo artefacts and gradient inversion artefacts at edges. It has been used to enhance the visual quality of an image. Most algorithms that used to enhance the detail of an image essentially depend on edge-preserving decomposition techniques. in general, the image consist of two major elements are a base layer and a detail layer, which extracted by edge-preserving decomposition algorithms. The detail layer is enhanced to improve the details of the generated image. we propose in this paper, a new model to preserve the sharp edges and achieve better visual quality than the existing norm-based algorithm to enhance the details of the image. Experiments show that the proposed method reduces the distortion at the edges. It improves the details of the generated image significantly.
Scientific Production of Psychology Program Directors from Peruvian Universities
Authors: Esteban Renzo Felipe Carranza , Hernández Ronald M. , Mamani-Benito Oscar , Chaparro Josué Edison Turpo
Published: November 2021

Scientific production studies help describe the progress of scientific knowledge in a discipline. Therefore, those who hold director positions should promote scientific production and publication of scientific knowledge to address health problems. The objective was to identify the scientific production of psychology program directors from Peruvian universities. A search was made for all psychology programs in Peruvian universities. Thus, psychology program directors’ scientific production was identified and analyzed in the Scopus and Web of Science databases between 2000 and 2019. The search for the directors’ scientific production was conducted through ORCID, GOOGLE SCHOLAR, CTI Vitae (former DINA), Scopus and Web of Science. Thirty-eight psychology program directors were identified, five of them conducted a scientific publication, all of them from private universities. Of the articles assessed, 50% and 60% had a psychology program director as first author or corresponding author. In addition, 70% were original articles, 40% of which were analytical studies. Psychology program directors’ scientific production is limited. The articles published are mainly original and are concentrated in Latin American journals. It is likely that, since they have no experience in scientific production and publication, their leadership in promoting research is vulnerable.
Makrostruktury społeczne w przedmiocie zainteresowania pedagogicznego
Authors: Modrzewski Jerzy
Published: November 2021

The problem of upbringing is one of the inherent elements of social experience and has accompanied the human since the invention of the form of organization of social life, known as the state. Remedy for the experienced problems should be various initiatives and constructs unfortunately most of which often become ideology. In this article, author attempts to describe the concept of upbringing problems through its deconstruction and categorization of its components, which is aimed at presenting the implications for social reality, both contemporary and historical.
Total lab automation: sample stability of clinical chemistry parameters in an automated storage and retrieval module
Authors: Vercruysse Kobe , Lambrecht Stijn , Oyaert Matthijs
Published: November 2021

Objectives

Automated storage and retrieval modules (SRM), as part of total lab automation (TLA) systems, offer tremendous practical and economic benefits. In contrast to manual storage systems, SRMs indicate continuous motion of samples and may leave samples prone to temperature fluctuations. This study investigates analyte stability in serum and heparin plasma within an automated storage module.

Methods

The stability of 28 common biochemistry analytes was investigated using 57 freshly obtained routine serum samples and 42 lithium-heparin plasma samples. Following baseline measurement, samples were stored at 2–8 °C in the automated SRM of the Accelerator a3600 TLA and reanalyzed at fixed time points (2, 4, 8, 12, 24, 48 and 72 h) on the Abbott Architect c16000 chemistry analyzer. The concentration at each time point was expressed as %-difference to the baseline value and mean results were compared to the criteria for desirable bias derived from the biological variation database.

Results

Nine of the analytes exceeded the bias criterion within 72 h after initial measurement in either serum samples, plasma samples or both. Lithium-heparin plasma samples showed increasing values for phosphor, potassium and lactate dehydrogenase (LDH), which were only considered stable for respectively 24, 12 and 4 h, glucose was considered stable for 8 h. Electrolyte concentrations and LDH activity significantly increased in serum samples beyond 48 h. Bicarbonate should not be performed as add-on test at all.

Conclusions

The presented data indicate that the conditions within an SRM have no clinical impact on sample stability and allow stable measurement of routine analytes within 72 h, comparable to manual storage facilities.
The Transcendental Parameters of “Nature as Universal Organism” in Schelling’sNaturphilosophie
Authors: Barton Jason
Published: November 2021

The minutiae of F.W.J. Schelling’sNaturphilosophiehave been perennially dismissed due to its allegedly infeasible and indefensible assertions about Nature, such as his designation of Nature as “universal organism.” In the realm of post-Kantian German Idealism, such a dismissive attitude toward Schelling’s so-calledobjective idealism, more often than not, develops itself along the lines of Hegel’s critique of Schelling’s conception of the Absolute (i.e., as static, fixed, undifferentiated, dull, and so on). In turn, I aim to accomplish two tasks in the following investigation. First, I intend to clarify Schelling’s characterization of Nature as universal organism through a practical or teleological, instead of a theoretical or metaphysical, approach. Second, I seek to undermine the Hegelian-influenced criticisms of Schelling’s “Absolute” by demonstrating the ways in which the practico-teleological characterization of Schelling’s formulation of Nature extends into his later philosophical works (i.e., hisIdentitätsphilosophieand hisFreiheitsschrift). Through these clarifications, I hope to emphasize the uniqueness and richness of Schelling’s configuration of Nature.
Therapeutic value of the metabolomic active neurotransmitter isorhynchophylline in the treatment of spontaneously hypertensive rats by regulating neurotransmitters
Authors: Alharbi Homood , Ahmad Mohammad , Tian Zhenhua , Yu Ruixue , Li Yun Lun
Published: November 2021

Hypertension is one of the most reported cardiovascular and cerebrovascular diseases with significantly high morbidity and mortality rates. This condition threatens the very existence of human beings. Numerous studies conducted earlier revealed the good therapeutic effect of isorhynchophylline on hypertension since the former regulates the metabolic disorders in neurotransmitters. However, the mechanism behind this action is yet to be deciphered. The current study followed the targeted metabolomics method to investigate the changes in the neurotransmitter level in the hippocampus of spontaneously hypertensive rats (SHRs) after the rats were treated with isorhynchophylline. The authors predicted the metabolic pathways involved in extensively modified neurotransmitters. Further, the expressions of metabolism-key enzymes in mRNA and protein levels were also determined. When treated with isorhynchophylline, it induced notably varying metabolomic profiles of the hippocampus in SHRs. Isorhynchophylline perturbed a total of seven extensively modified neurotransmitters as well as the primarily related pathways such as tyrosine and glutamate metabolism. An increase in the key metabolic enzymes such as DDC, MAO, COMT, TH, and DβH was observed in the SHR group, whereas their levels decreased after treatment with isorhynchophylline. The expression of GAD67 established cross-current validity. So, isorhynchophylline has been proved to have potential therapeutic value to treat hypertension via tyrosine and glutamate metabolism in the hippocampus. Further, the current study also opened new ventures to further investigate the working mechanism of isorhynchophylline in hypertension.
Tudásmenedzsment, felsőoktatás és zeneipar – és a tudás, ami legalább olyan értékes, mint az, amit a „tantermekben tanítanak”
Authors: Morcz Fruzsina
Published: November 2021

A kreatív iparágak fogalmának meghatározása a brit kultúrakutatáshoz, illetve kultúrpolitikához köthető, a vonatkozó egyetemi programokkal foglalkozó szakirodalmak zöme is a brit oktatást vizsgálja, német, ausztrál és amerikai, a kreatívipar alá sorolható zeneipari képzésekről írt tanulmányok száma igen alacsony. Az írás áttekinti a felsőoktatásban működő kreatívipari, illetve zeneipari menedzsment képzésekkel kapcsolatos kritikákat, fő fókuszát az Angliában működő kurzusok jelentik. Ezeket beindulásuk óta folyamatos, határozott és hangos kritika kíséri. Az iparágak képviselőinek véleménye, elismert oktatáskutatók elemzései és végzős hallgatók panaszai mind azt sugallják, a kreatívipari képzések vezetői sem a kurzusok tervezésénél, sem azok működtetésénél nem ügyelnek eléggé a munkaerőpiacon megkívánt hallgatói készségek fejlesztésre, sőt, az oktatók jelenős része az akadémiai munkával, illetve a kritikai gondolkodás kialakulásával szembeni veszélynek tekinti azt. A szerző az amerikai pszichológus, Robert J. Sternberg és kollégái által kidolgozott elméletek segítségével cáfolja az akadémiai tudás tacit tudással szembeni elsődlegességét a kreatívipari képzések esetében. Sternberg és munkatársai kimutatták, a tacit tudás és a szakmai, munkaerőpiaci siker között egyenes összefüggés található, ahogy a tacit tudás - szakértelem - praktikus intelligencia - sikeres intelligencia között is. A tanulmány rámutat, a zeneipari munkaerőpiac esetében meghatározó szereppel bíró tacit tudással kapcsolatos attutűdök átalakítása, a tacit tudás szervezett keretek között történő átadása, új tudásmenedzsment módszerek alkalmazása az egyetemi zeneipari menedzsment kurzusok szakmai sikerének kulcsa.
Russian-German relations in the context of A. Merkel's visits to Moscow and Kiev
Authors:   Institute of Europe of Russian Academy Sciences, Belov Vladislav
Published: November 2021

Federal Chancellor A. Merkel, who is leaving her post after the Bundestag elections in September, visited Moscow and Kiev on August 20 and 22. The working visits became part of the consolidation of foreign policy foothold, to be transferred to the future government coalition and its leader. The author analyzes results of the negotiations between Bundescanzlerin and presidents of Russia and Ukraine and their significance for the future of Russian-German relations.
Public Support for Using “Second Chance” Mechanisms to Reconsider Long-Term Prison Sentences for Drug Crimes
Authors: Berryessa Colleen M.
Published: November 2021

Using a national sample of U.S. adults (N = 371), this study experimentally examines (1) public support for the use of strategies that provide early release (i.e., “second chance” mechanisms) to individuals serving long-term prison sentences for drug crimes; and (2) how levels of support, and reasons for support, may vary depending on the type of drug-related offense. Results show moderate levels of support for using second chance mechanisms, both generally and in relation to specific strategies commonly available across jurisdictions, for a range of drug offenders. Yet participants showed significantly more support for using presumptive parole, elimination of parole revocations for technical violations, second-look sentencing, and compassionate release in the cases of those incarcerated long term for serious trafficking of marijuana, as compared to serious trafficking of serious drugs. Data also suggest that the public finds a range of factors—including the original sentence being extreme by international standards, extreme due to racially biased practices, out of step with current sentencing values/practices, too costly, and continuing to incarcerate someone unlikely to be a public safety threat—as at least moderately important to their support for the use of second chance mechanisms across drug crimes, and the importance of these factors to that support does not appear to differ significantly based on the type of drug offense. The importance of these results for policy making and utilization are discussed, as well as implications for reducing our historical reliance on drug-related incarceration.
The nucleoporin Nup50 activates the Ran guanine nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis
Authors: Holzer Guillaume , De Magistris Paola , Gramminger Cathrin , Sachdev Ruchika , Magalska Adriana , Schooley Allana , Scheufen Anja , Lennartz Birgitt , Tatarek‐Nossol Marianna , Lue Hongqi , Linder Monika I , Kutay Ulrike , Preisinger Christian , Moreno‐Andres Daniel , Antonin Wolfram
Published: November 2021

During mitotic exit, thousands of nuclear pore complexes (NPCs) assemble concomitant with the nuclear envelope to build a transport‐competent nucleus. Here, we show that Nup50 plays a crucial role in NPC assembly independent of its well‐established function in nuclear transport. RNAi‐mediated downregulation in cells or immunodepletion of Nup50 protein inXenopusegg extracts interferes with NPC assembly. We define a conserved central region of 46 residues in Nup50 that is crucial for Nup153 and MEL28/ELYS binding, and for NPC interaction. Surprisingly, neither NPC interaction nor binding of Nup50 to importin α/β, the GTPase Ran, or chromatin is crucial for its function in the assembly process. Instead, an N‐terminal fragment of Nup50 can stimulate the Ran GTPase guanine nucleotide exchange factor RCC1 and NPC assembly, indicating that Nup50 acts via the Ran system in NPC reformation at the end of mitosis. In support of this conclusion, Nup50 mutants defective in RCC1 binding and stimulation cannot replace the wild‐type protein inin vitroNPC assembly assays, whereas excess RCC1 can compensate the loss of Nup50.
PENGARUH ORIENTASI SUDUT SERAT PANDAN DURI TERHADAP KETANGGUHAN IMPACT KOMPOSIT SEBAGAI MATERIAL ALTERNATIF BUMPER MOBIL
Authors: Pambudi Rizqi Luhur , Yudiono Heri
Published: November 2021

Seiring dengan berkembangnya teknologi dan sains, manusia telah melakukan beberapa inovasi dalam penggunaan teknik material komposit untuk mendapatkan material yang memiliki kualitas lebih baik. Pengujian impactadalah salah satu pengujian mekanik yang dilakukan untuk mengetahui nilai impact pada suatu material. Pada penelitian ini digunakan komposit serat pandan duri dengan variasi orientasi sudut serat dan bumper mobil Toyota Avanza sebagai pembanding yang kemudian dilakukan pengujian impact untuk mengetahui nilai impact pada komposit. Hasil pengujian impact menunjukkan bahwa spesimen komposit sampleA (00 /0o /0o /0o ) memiliki nilai impact yang lebih tinggi dibandingkan spesimen komposit lainnya yaitu dengan rata â€“ rata energi serap 0,44 J, rata â€“ rata ketangguhan impact 0,0124 J/mm2 , dan sudut akhir (ð›½) 145,96o . Akan tetapi nilai impact spesimen komposit sampleA jauh dibawah nilai impact spesimen bumper mobil dengan rata â€“ rata energi serap 1,42 J, rata â€“ rata ketangguhan impact 0,0388 J/mm2 , dan sudut akhir (ð›½) 139,05o .
The Flexibility of the “F” Word
Authors: Machmudah Deinda Ratih
Published: November 2021

The “f” word (fuck) cannot be separated from its taboo nature. This can reveal more deeply about its use which can be found every day that the “f” word is not always used in negative terms and may be useful to enrich the knowledge about the characteristics of the “f” word and to reduce the stigma about it that it has more than negative purpose in expressing emotions. This research would also clarify the reasons for the versatility of the “f” word itself because of the kind that can be used to convey the sense of a specific emotional situation. This study was created because of the shortcomings that the previous study had; Horvat (2016), Jay and Janschewitz (2008), and Pluszczyk (2015) who have not studied the function of the “f” word in detail. So the motivation is created with documentation technique and applying the framework of Shiedlower (1999) and Wang (2013) to further discuss that the “f” word can be flexible in terms of word elements and their function in this study. The results have 6 different types of word element and 4 functions of “f” word swearing
“Listening is Hard”: ADDIE Model on the Development of English Listening Worksheets
Authors: Furwana Dewi , Syam Andi Tenrisanna
Published: November 2021

The authors’ pre-observation showed that when students learn listening skills, the students faced some difficulties. The students found difficulty expressing their ideas because they found many complex vocabularies, the audio text uses advanced grammar, and the native speaker speaks too fast. Therefore, to solve those students’ problems, the authors proposed to develop the appropriate listening worksheet for the English education study program of IAIN Palopo. Then, the authors applied Research and Development method and used the ADDIE model. 18 students of the English education study program IAIN Palopo were involved as the research subject. The research instruments used were observation and questionnaire. From observing, analysing students’ needs, developing the materials, evaluating expert judgments, conducting try-out materials, revising the product, the final product of this study is listening worksheets stored in a compact disc. The worksheets consist of a course grid, learning objective, language note, pre-activity, whilst-activity and post-activity. The authors expect that this worksheet will be useful for EFL teachers whose students' listening skills are still below the expected level of competence.
A Review of Machine Translation Tools: The Translation’s Ability
Authors: Fitria Tira Nur
Published: November 2021

The objective of the research is to review the ability of online machine translator tools includes Google Translate (GT), Collin Translator (CT), Bing Translator (BT), Yandex Translator (YT), Systran Translate (ST), and IBM Translator (IT). This research applies descriptive qualitative. The documentation was used in this study. The result of the analysis shows that the translation results are different, both from the style of language and the choice of words used by each machine translation tool. Thus, directly or indirectly, whether consciously or not, each translation machine carries its characteristics. Machine translation technology cannot be separated from the active role of humans. In other words, it will always be the best choice for users to rely on expert translation rather than machine translation. But no machine translator can be as accurate as human skills in producing translation products. In particular, the field of translation is also concerned with machine translation to support the performance of translators in analyzing the diction used as an element of language. In this regard, it needs to be underlined that the existence of machine translation is an additional facility in the world of translation, not as the main means of translation because the sophistication of the machine will not be able to match the flexibility of the human brain's cognitive abilities in adjusting the translation results according to the existing context. Accurate translation is sometimes subjective, relatively often temporal. Therefore, it is permissible for translating by more than one machine translator
Women in the Whirlpool: Traversing the Tie-up of Personality and Work-Life Balance of Pakistani Academicians
Authors: Shahin Salima , Baloch Muhammad Nawaz , Shaikh Najia , Ibrahim Iqra , Abbassi Ahsan Ali
Published: November 2021

This research strives to explain the impact of personality type on the work-life balance of women academicians. With the positivist paradigm and quantitative approach, this study has been conducted with a survey methodology. Data was collected from 362 women academicians on adopted instruments and analyzed with multiple regression and ANOVA tests. Results revealed a positive effect of agreeableness, extraversion, and openness personality types on work-life balance. Those women academicians who are with agreeableness personalities are more in a capacity to manage their work-life balance. The results also show a difference in managing the work-life balance between those who are single and married, those who belong to a nuclear family, and those who belong to joint or extended families. This study will facilitate them to develop the personality type which has more capacity to manage work-life balance. It will help policymakers to facilitate women academicians to ensure better work-life balance.JEL Classification: M12How to Cite:Shahin, S., Baloch, M. N., Shaikh, N., Ibrahim, I., & Abbassi, A. A. (2021). Women in the Whirlpool: Traversing the Tie-up of Personality and Work-Life Balance of Pakistani Academicians. Etikonomi, 20(2), xx – xx. https://doi.org/10.15408/etk.v20i2.17272.
The Reviews on Sustainable and Responsible Investment (SRIs) Practices According to Maqasid Shariah and Maslahah Perspectives
Authors: Haji Wahab Muhammad Zarunnaim , Naim Asmadi Mohamed
Published: November 2021

The present study aims to explore SRIs practices based on Maqasid Shariah and Maslahah's points of view. A qualitative method via content analysis document was advocated to address the link between all concepts. The analysis revealed that SRIs, Maqasid Shariah and Maslahah share similar aims and goals to promote better environmental practices and social and governance issues. Thus, the paper concludes that the concept of SRIs does not contradict Maqasid Shariah and Maslahah in Islamic perspectives. However, a few criteria in the Environmental, Social and Governance (ESG) concept that govern the SRIs practices like promoting human rights, freedom of expression, and censorship need further clarification to align with Shariah principles. The paper can enlighten the reader, especially in terms of the capabilities of SRIs practices (which is from West philosophy) to suit Maqasid Shariah and Maslahah in Islamic perspectives.JEL Classification: G2, G4, I13, N2How to Cite:Wahab, M. Z. H., & Naim, A. M. (2021). The Reviews on Sustainable and Responsible Investment (SRIs) Practices According to Maqasid Shariah and Maslahah Perspectives. Etikonomi, 20(2), xx – xx. https://doi.org/10.15408/etk.v20i2.18053.
The Role of Technology Usage in Mediating Intellectual Capital on SMEs Performance During the Covid-19 Era
Authors: Faisol Faisol , Astuti Puji , Winarko Sigit Puji
Published: November 2021

This study examines technology in mediating human capital, customer capital, and organizational capital on SMEs' performance during Covid-19. To test the hypothesis, the PLS-SEM method was applied. Data collection was conducted by sharing questionnaiers to 150 owners of small industrial cluster in East Java, Indonesia.The empirical results show that human capital and technology usage directly affect significantly on SMEs' performance. Furthermore, technology usage has a significant influence in mediating human capital on firms' performance. We provide implications for using technology for practice and using a socio-technical approach by SMEs to face challenges related to their work organization in response to COVID-19 while maintaining their activities. We hope that our reflection will be a source of thought for scholars and practitioners to explore further using technology for SMEs to secure business continuity during COVID-19.JEL Classification: O2, O34, M21How to Cite:Faisol, Astuti, P., Winarko, S. P. (2021). The Role of Technology Usage in Mediating Intellectual Capital on SMEs Performance During the Covid-19 Era. Etikonomi, 20(2), xx – xx. https://doi.org/10.15408/etk.v20i2.20172.
Fiscal Policy of Economic Development: Comparative Characteristics of Ukraine and Poland
Authors: Sliusarchuk Olha , Lavrov Ruslan , Kuybida Vasyl , Slatvinskyi Maksym , Zelenskyi Andrii
Published: November 2021

In order to achieve the purpose outlined, this research uses the following methods: analysis and synthesis; economic and statistical analysis and comparison; economic and mathematical; generalization. The result shows that Poland's fiscal policy aims at developing economic infrastructure and building an economic model of the state based on the manufacture of products with a high share of value-added. However, the fiscal policy of Ukraine does not have significant effects on economic development due to the use of such instruments as public debt and capital expenditures. However, the external debt dependence of the state is relatively high. Nevertheless, it proves that the fiscal policy of Ukraine does not increase the level of economic complexity and development of the processing industry through the implementation of tax benefits. It proposes to increase the efficiency of tax authorities in Ukraine in terms of combating the shadow economy, boost the share of capital expenditures and raise the level of conversion of public debt into economic growth.JEL Classification: E62, F63, H21How to Cite:Petrunenko, I., Lavrov, R., Kuybida, V., Slatvinskyi, M., & Zelenskyi, A. (2021). Fiscal Policy of Economic Development: Comparative Characteristics of Ukraine and Poland. Etikonomi, 20(2), xx– xx. https://doi.org/10.15408/etk.v20i2.22013.
Evaluation of a policy enforcement solution in telemedicine with offline use cases
Authors: Szabó Zoltán
Published: November 2021

The emerging popularity of telemedicine solutions brought an alarming problem due to the lack of proper access control solutions. With the inclusion of multi-tiered, heterogeneous infrastructures containing Internet of things and edge computing elements, the severity and complexity of the problem became even more alarming, calling for an established access control framework and methodology. The goal of the research is to define a possible solution with a focus on native cloud integration, possible deployment at multiple points along the path of the healthcare data, and adaptation of the fast healthcare interoperability resources standard. In this paper, the importance of this issue in offline use cases is presented and the effectiveness of the proposed solution is evaluated.
Street character and current practices influence
Authors: Alamoush Saja Jamil , Ja'afar Nor Haslina , Kertész András
Published: November 2021

Rapid development has affected the elements of urban spaces adversely, particularly streets. These changes produce faceless cities with high dependency on vehicles for transportation to key ‘consumers’ aside from buildings that are not designed for the local environment and local needs. In urban design, concerns on character affect the sense of place. Thus, this paper assesses the crucial element of streets with respect to design and character in the urban setting, the subsequent issues, and the recommended solution. This study focuses on the scenarios that threaten today's street design. This work will discuss the advantages of traditional streets, which could be a potential solution to the issues mentioned earlier. Finally, a street design based on the traditional street model is proposed to fulfill the criteria necessitated by the local community.
Music in a Concussive Monologue
Authors: Gilbertson Simon , Hebert David Gabriel
Published: November 2021

The co-authors, a music therapist and a musicologist who suffered a concussion, collaboratively develop an autoethnography detailing the phenomenological experience of concussion and the gradually increasing role of music throughout the recovery process. Along the way, they discover new things about music, the mind, scholarship, and themselves.
Laboratorio de Paisaje Verde / UNESCO
Authors: Guimaraens Dinah Tereza Papi De , Veras Valéria Lins Do Rego , Gomes Wellington Silva
Published: November 2021

Inserción de MACquinho (único edificio de Oscar Niemeyer construido en una favela brasileña) en la Ruta Cultural del Camino Niemeyer con proyectos de accesibilidad, señalización urbana y comunicación digital como el VISOR DE PAISAJE / UNESCO, dentro de la misión pedagógica del Laboratorio de Paisaje y Lugar (LAPALU) del Programa de Postgrado en Arquitectura y Urbanismo (PPGAU) de la Universidad Federal Fluminense (UFF). El estudio de caso enfatiza nuevos hitos conceptuales de prototipos verdes en espacios vacíos de la periferia urbana en términos de arquitectura, urbanismo y paisajismo, en un entorno vulnerable del contexto urbano de la favela Morro do Palácio, Niterói / RJ, que es un asentamiento humano con unos seis mil habitantes. Una periferia socioeconómica anexa, pero excluida del Camino Niemeyer, aunque contiene una obra (MACquinho) de este reconocido arquitecto modernista ubicada en la Línea Paisajística Río de Janeiro / Niterói que fue registrada, el 01/07/2012, por la UNESCO, como el primer Paisaje Cultural Urbano Mundial. La metodología participativa de paisaje cultural sostenible de este proyecto de la Prorrectoría de Extensión Universitaria (PROEX) y la Agencia de Innovación (AGIR) de la Prorrectoría de Investigación, Posgrado e Innovación (PROPPi) de la Universidad Federal Fluminense (UFF) cuenta con la colaboración de la Asociación de Vecinos del Morro do Palácio, con el objetivo de contribuir a la propuesta de cotización del Instituto de Patrimonio Histórico y Artístico Nacional (IPHAN) de MACquinho, junto a su socio institucional, que ya figura en la lista, el 22/05/20 2021, el Museo de Arte Contemporáneo (MAC-Niterói).
A Neurotoxocariasis Case Manifesting Multiple Cerebral Infarction and Eosinophilic Meningoencephalitis
Authors: Kang SangJoon , Park Jaeyoung , Jeong Hoe Jong , Joo Jae-Jeong , Kim Seungmin
Published: November 2021

Although Toxocara canis is known to cross the blood-brain barrier, central nervous system involvement is uncommon. Clinical manifestations vary and include cerebral infarction, meningoencephalitis, myelitis, vasculitis or seizure. However cerebral infarction and meningoencephalitis rarely occur simultaneously. We report a case of multiple cerebral infarction combined with eosinophilic meningoencephalitis in a patient with neurotoxocariasis. After control of increased intracranial pressure and treatment with albendazole and steroid, the patient’s clinical symptoms improved markedly.