bluuebunny/crossref_metadata_2025 huggingface dataset:
Documentação das manifestações patológicas do Pórtico do Batismo Cultural de Goiânia - monumento histórico Art Déco
Authors: Lara Pio Santos Taís , Silva Júnior Paulo Francinete
Published: September 2021

Este artigo tem o objetivo de apresentar a metodologia para a inspeção e o mapeamento das manifestações patológicas no monumento Pórtico do Batismo Cultural de Goiânia. É um monumento do início dos anos 40 do século XX, representante do estilo arquitetônico art déco. No ano de 2003 esse monumento foi tombado pelo Instituto do Patrimônio Histórico e Artístico Nacional, porém apesar do seu inestimável valor histórico, a estrutura apresenta diversas manifestações patológicas. Para alcançar esse objetivo foram realizados os seguintes procedimentos: (1) inspeção visual; (2) registro fotográfico; (3) anamnese e (4) ensaios. Os ensaios realizados foram esclerometria, pacômetria e medição de deformações. As principais manifestações patológicas identificadas foram fissuração, destacamento de argamassa, corrosão de armaduras e deformação.
Evaluación del efecto de la arcilla de desecho de un proceso de producción de polioles como sustituto parcial del cemento en concreto armado
Authors: Troconis de Rincón Oladis , Millano Valentina , Suarez Wilfredo , Navarro Luis , De Turris Antonio , Amesty Roque
Published: September 2021

En este trabajo se evaluó el efecto de la arcilla de desecho de un proceso de producción de polioles, como sustituto parcial del cemento en concreto armado, en concentraciones del 0%, 5% y 10%. Se determinaron las características físico-mecánicas del concreto y electroquímicas del acero durante un periodo de 356 días (ISO 11474), en probetas de 15x10x5 cm, con dos barras de acero embebidas en el concreto. Los resultados indican que la resistencia a la compresión disminuyó proporcionalmente según el contenido de arcilla; incrementándose para los 90 días de curado. Sin embargo, la sorción capilar del concreto disminuyó, lo cual permitió que el acero en ambiente marino mantuviera su estado pasivo por más tiempo que sus blancos, para las relaciones a/c evaluadas (0,45 y 0,60).
Konservasi In Vitro Tanaman Hias Akuatik Bacopa australis dan Alternanthera reineckii Menggunakan Paklobutrazol dan Benzil Adenin
Authors: Lestari Endang Gati , Nugraha Media Fitri Isma , Yunita Rossa , Aini Azizi Alfia Annur
Published: September 2021

Tanaman Bacopa australis dan Alternanthera reineckii mempunyai nilai ekonomi cukup tinggi sebagai tanaman hias akuatik, sehingga berpotensi untuk dikembangkan. Pertumbuhan minimal merupakan teknik penyimpanan in vitro yang banyak digunakan dengan menggunakan senyawa penghambat tumbuh seperti paklobutrazol (PBZ), sisosel (CCC), ansimidol, serta komponen osmotik seperti sorbitol dan manitol. Teknik kultur in vitro mempunyai peran penting untuk penyimpanan biakan, karena biakan dapat disimpan sampai beberapa bulan tanpa harus dilakukan subkultur. Tujuan penelitian ini adalah untuk mengetahui pengaruh zat penghambat paklobutrazol dan interaksinya dengan zat pengatur tumbuh benzil adenin (BA) untuk menghambat pertumbuhan biakan serta visual biakan selama penyimpanan. Bahan yang digunakan adalah tunas in vitro B. australis dan A. reineckii umur 4 bulan, media yang diuji adalah media dasar Murashige dan Skoog (MS) + PBZ (0,1, 0,3, 0,5, dan 0,7 mg/l) + BA (0 dan 0,1 mg/l). Penelitian dilaksanakan di Laboratorium Kultur Jaringan BB Biogen pada bulan Januari sampai Juli 2019. Hasil penelitian menunjukkan bahwa PBZ 0,1−0,7 mg/l dapat menghambat pertumbuhan tinggi tunas, jumlah tunas, jumlah akar, panjang akar, dan jumlah daun dari biakan in vitro B. australis dan A. reineckii demikian pula interaksinya dengan sitokinin BA 0,1 mg/l, yang membuat visual biakan tetap tegar sampai 6 bulan setelah tanam. Formula media yang diperoleh diharapkan dapat diaplikasikan untuk penyimpanan plasma nutfah tanaman akuatik yang sejenis.

 
Effects of the Full Coverage Policy of Essential Medicines on Inequality in Medication Adherence: A Longitudinal Study in Taizhou, China
Authors: Guo Zhigang , Zheng Liguang , Fu Mengyuan , Li Huangqianyu , Bai Lin , Guan Xiaodong , Shi Luwen
Published: September 2021

Background: The full coverage policy for essential medicines (FCPEMs) was proposed and implemented in Taizhou city of Zhejiang Province of China to promote equal access and adherence to medicines. This study aimed to examine the effects of FCPEMs on the inequality in medication adherence among local patients with hypertension and diabetes, and to explore their influencing factorsMethods: We collected electronic health records of patients with hypertension and diabetes of three districts of Taizhou from 2011-2016. With the implementation time of FCPEMs being different, we applied a retrospective longitudinal study design and selected the records of 1 baseline year before and 3 follow-up years after following the implementation of FCPEMs. All data entries of the same patient were aggregated and generated a dataset with 4-year longitudinal data. The concentration index (CI) and its decomposition method were employed to measure the factors contributing to inequality in medication adherence and the role played by FCPEMs.Results: The sample size of the 4 years retrospective longitudinal data rose from 264,836 to 315,677, 340,512 and 355,676 individuals and the proportion of the patient taking the free medicines were 17.6% to 25.0% and 29.8% after FCPEMs. The proportion of patients with high adherence increased from 39.9% to 51.6%, 57.2%, 60.5% and CI changed from 0.073 to -0.011, -0.029, -0.035, where the rate of the contribution of FCPEMs were 54.792%, 1.223% and -19.092% and ranked 2nd, 7th and 2nd after the implementation of FCPEMs. The changes in CI of medication adherence for every two years were -0.084, -0.018, -0.006, and the contribution of FCPEMs were -0.006, 0.006, 0.007, ranking the 2nd, 2nd and 1st and mainly attributed to the changes of CI of FCPEMs.Conclusions: The medication adherence of patients with hypertension and diabetes improved after the implementation FCPEMs in Taizhou, but the inequality did not show a consistent rate of improvement. In general, FCPEMs contributed to improvements in the inequality in medication adherence. FCPEMs could be a protective factor against the income-related inequalities, but this would need further investigations and to be accompanied by other systematic efforts.
Mechanical And Thermodynamic Stabilities, Half-Metallic Property of Co2CrAl Heuslerene: A DFT Study
Authors: Boochani A. , Asshabi M. , Jamal M. , Shahrokhi M. , Nezafat N. B. , Salimi N. , Amiri M. , Yari A. , Solaymani S. , Dezfuli F. Motamed , Asad-Abadi S. Jalali , Zelati A. , Vahabzadeh N. A.
Published: September 2021

In the present study, the physical properties of the ground state in bulk and Co2CrAl Heuslerene compound are investigated by density functional theory (DFT). The effects of exchange-correlation potential on the calculations have been also investigated by GGA, GGA+U, and GGA+U+mBJ approximately. Here, three graphene-like structures with the thickness of about 8 Bohr have been labeled as α, β, and ϒ phases. The results demonstrate the mechanical stability of bulk Co2CrAl since it passes the elastic stability test. Having proved the static stability of the bulk and three Heuslerene shapes of Co2CrAl, it is essential to study dynamic stability as well. The accessible region in the thermodynamic phase diagrams confirms the thermodynamic stability of bulk Co2CrAl and all 2D phases of the compound. According to our electronic calculations, the bulk phase of Co2CrAl is a half-metal whose values of magnetic moment and spin polarization is 3 μB and 100% at the Fermi level, respectively. Besides, α and ϒ phases show the metal behavior for both spin directions in all imposed approximations. Finally, β phase exhibits different magnetic properties for different approximations. From 3eV to 2eV, GGA and GGA+U reveal the magnetic anisotropic and isotropic nature. Besides, an extremely anisotropic nature is observed at the Fermi level by GGA+U+mbJ.
First-In-Human Results On The Biodistribution, Pharmacokinetics, And Dosimetry of [177Lu]Lu-DOTA.SA.FAPi and [177Lu]Lu-DOTAGA.(SA.FAPi)2 in Patients with Various End-stage Cancers
Authors: Ballal Sanjana , Yadav Madhav Prasad , Moon Euy Sung , Kramer Vasko S , Roesch Frank , Kumari Samta , Bal Chandrasekhar
Published: September 2021

Purpose: The present study aimed to evaluate and compare the biodistribution, pharmacokinetics, dosimetry of [177Lu]Lu-DOTA.SA.FAPi, and [177Lu]Lu-DOTAGA.(SA.FAPi)2 in patients with various cancers.Methods: The FAPi agents, [177Lu]Lu-DOTA.SA.FAPi and [177Lu]Lu-DOTAGA.(SA.FAPi)2 were administered in two different groups of patients. Three patients (mean age; 50 years) were treated with a median cumulative activity of 2.96 GBq (IQR: 2.2 – 3 GBq) [177Lu]Lu-DOTA.SA.FAPi and seven (mean age; 51 years) were treated with 1.48 GBq (IQR: 0.6 – 1.5) of [177Lu]Lu-DOTAGA.(SA.FAPi)2. Patients in both the groups underwent serial imaging whole-body planar and SPECT/CT scans that were acquired between 1 hour and 168 hours post-injection (p.i.)The residence time and absorbed dose estimate in the source organs and tumor were calculated using OLINDA/EXM 2.2 software. Time versus activity graphs were plotted to determine the effective half-life (Te) in the whole body and lesions for both the radiotracers. Results: Physiological uptake of [177Lu]Lu-DOTA.SA.FAPi was observed in the kidneys, colon, pancreas, liver, gall bladder, oral mucosa, lacrimal glands, and urinary bladder contents. Physiological biodistribution of [177Lu]Lu-DOTAGA.(SA.FAPi)2 involved liver, gall bladder, colon, pancreas, kidneys, and urinary bladder contents, lacrimal glands, oral mucosa, and salivary glands. The whole body effective dose for [177Lu]Lu-DOTAGA.(SA.FAPi)2 was significantly higher than [177Lu]Lu-DOTA.SA.FAPi [2.26E-01 ± 1.24E-01; vs. 6.22E-02 ± 9.96E-03 mSv/MBq, P-0.058). In the [177Lu]Lu-DOTA.SA.FAPi group, the highest absorbed dose were noted in the Kidneys (0.618 ± 0.015 Gy/GBq), followed by a colon (right colon: 0.472 Gy/GBq and left colon: 0.43 Gy/GBq). In the [177Lu]Lu-DOTAGA.(SA.FAPi)2 group, the colon received the highest absorbed dose (right colon: 1.16 Gy/GBq and left colon: 2.87 Gy/GBq), and demonstrated a significantly higher mean absorbed dose than [177Lu]Lu-DOTA.SA.FAPi (P < 0.011). [177Lu]Lu-DOTAGA.(SA.FAPi)2 had significantly longer median whole-body Te compared to that of [177Lu]Lu-DOTA.SA.FAPi [46.2 h (IQR: 38.5 – 70.1) vs. 23.1 h (IQR: 17.8 – 31.5); P-0.0167]. The median absorbed doses to the lesions were 6.03E-01(IQR: 2.30E-01 - 1.81E+00) Gy/GBq and 6.70E+00 (IQR: 3.40E+00 - 4.9E+01) Gy/GBq dose per cycle in the [177Lu]Lu-DOTA.SA.FAPi, and [177Lu]Lu-DOTAGA.(SA.FAPi)2 groups, respectively. Conclusion: The first clinical dosimetry study demonstrated significantly higher tumor absorbed doses with [177Lu]Lu-DOTAGA.(SA.FAPi)2 compared to [177Lu]Lu-DOTA.SA.FAPi. [177Lu]Lu-DOTAGA.(SA.FAPi)2 is safe and unveiled new frontiers to treat various end-stage cancer patients with a theranostic approach.
Epidemiological Profile of Children with Neurodevelopmental Disorders in a Diagnostic Center in Southern Puerto Rico, 2006-2017
Authors: Pacheco Maria , Bauza Laura Deliz , Martinez Iris , Morales Luisa
Published: September 2021

Objective: This study has the purpose of developing an epidemiological profile of children with Neurodevelopmental disorders in southern Puerto Rico Methods: This is an exploratory study with a mixed design that carried out in a diagnostic center located in Ponce, Puerto Rico. The population under study were children within 0-18 years old of both sexes diagnosed with a Neurodevelopmental disorder using the DSM- 4 and DSM-5 criteria. The sample under investigation were all the children in the secondary database of children who received health services in the diagnostic center within 2016-2017. Additionally, to the data from the secondary database, a hand-writing record review was performed to obtain data related to comorbidities. Bivariate and multivariate analysis evaluated the association between each Neurodevelopmental disorder, and each disease reported in the family history of diseases. Also, bivariate and multivariate analysis assessed the association between each Neurodevelopmental disorder, and each comorbidity reported. Results and conclusions: The mean age and standard deviation of the sample were 5.2 ± 3.20, and 80.5% were males. Also, most of the children lived in Ponce, Puerto Rico. The sample size did not have normal distribution because the sample size is too smaller and not selected by probabilistic methods. Furthermore, 88.2% of the children received a previous evaluation related to the problem, and 70.5% received some treatment for the symptoms. The results revealed that the Neurodevelopmental disorders co-occurred. Also, other comorbidities co-occurred with these disorders. Mental disorders are associated with Autism, ADHD and Communication Disorders. Also, family history of Mental disorders is associated with Autism.
Metformin Sensitizes Leukemic Cells to Cytotoxic Lymphocytes by Increasing Expression of Intercellular Adhesion Molecule-1 (ICAM-1)
Authors: Allende-Vega Nerea , Brualla Joaquin Marco , Falvo Paolo , Alexia Catherine , Constantinides Michael , Maudave Alexis Fayd’herbe , Coenon Lois , Gitenay Delphine , Mitola Giulia , Massa Paul , Orecchioni Stefania , Bertolini Francesco , Marzo Isabel , Anel Alberto , Villalba Martin
Published: September 2021

Solid tumor cells have an altered metabolism that can protect them from cytotoxic lymphocytes. The antidiabetic drug metformin modifies tumor cell metabolism and several clinical trials are testing its effectiveness for the treatment of solid cancers. The use of metformin in hematologic cancers has received much less attention, although allogeneic cytotoxic lymphocytes are very effective against these tumors. We show here that metformin induces expression of Natural Killer G2-D (NKG2D) ligands (NKG2DL) and intercellular adhesion molecule-1 (ICAM-1), a ligand of the lymphocyte function-associated antigen 1 (LFA-1). This leads to enhance sensitivity to cytotoxic lymphocytes. Overexpression of antiapoptotic Bcl-2 family members decrease both metformin effects. The sensitization to activated cytotoxic lymphocytes is mainly mediated by the increase on ICAM-1 levels, which favors cytotoxic lymphocytes binding to tumor cells. Finally, metformin decreases the growth of human hematological tumor cells in xenograft models, mainly in presence of monoclonal antibodies that recognize tumor antigens. Our results suggest that metformin could improve cytotoxic lymphocyte-mediated therapy.
Seismic Performance of Hybrid SMA/Steel Reinforced Hollow Section Concrete Bridge Piers
Authors: Wakjira Tadesse Gemeda , Alam M. Shahria , Ebead Usama
Published: September 2021

Concrete bridge piers reinforced with conventional steel bars experience large permanent (residual) deformation that may lead to uneconomical repair or demotion of bridges due to their non-functionality post strong seismic event. Thus, sufficiently ductile materials are required to reinforce concrete bridge piers in the plastic hinge zone in order to limit their permanent damage and deformation post-earthquake event. Previous studies showed that partial replacement of conventional steel reinforcement bars with superelastic shape memory alloy (SMA) bars in the plastic hinge zone of concrete bridge piers has the capacity to limit the residual deformation owing to the superior self-centering properties of SMA bars. In this study, the efficacy of hybrid SMA/steel reinforcement for hollow section concrete bridge piers under combined reverse cyclic and constant axial loading is numerically investigated for the first time. The responses of the piers were evaluated in terms of different performance indices including hysteretic characteristics, residual deformation, energy dissipation capacity, and self-centering capacity. A sensitivity analysis was used to explore the main effects of key design parameters and their interactions on each performance index at four damage states, namely, complete, extensive, moderate, and slight damage states. The results of this study demonstrate the effectiveness of hybrid SMA/steel reinforcement for enhancing the seismic behavior of hollow section concrete bridge piers.
Vascular Inflammation in Lungs of Patients with Fatal Coronavirus Disease 2019 (COVID-19): Possible Role for the NLRP3 Inflammasome
Authors: Paul Oindrila , Tao Jian Qin , West Eric , Litzky Leslie , Feldman Michael , Montone Kathleen , Rajapakse Chamith , Bermudez Christian , Chatterjee Shampa
Published: September 2021

Background: Hyperinflammation is a key event that occurs with SARS-CoV-2 infection. In the lung, hyperinflammation leads to structural damage to tissue. To date, numerous lung histological studies have shown extensive alveolar damage, but there is scarce documentation of vascular inflammation in postmortem lung tissue. Methods: Lung sections from 8 COVID-19 affected and 11 non-COVID-19 subjects [of which 8 were acute respiratory disease syndrome (ARDS) affected and 3 were from subjects with non-respiratory diseases] were stained for H & E to ascertain histopathological features including presence of thrombi/microthrombi. Inflammation along the vessel wall was also monitored by quantification of the expression of moieties of the NLRP3 inflammasome pathway (NLRP3 and caspase-1). Results: In lungs from “fatal COVID-19”, vascular changes in the form of microthrombi in small vessels, arterial thrombosis, and organization were extensive as compared to lungs from “non-COVID-19 non respiratory disease” affected subjects. The NLRP3 pathway components were significantly higher in lungs from COVID-19 subjects as compared to non-COVID-19 fatal cases without respiratory disease. No significant differences were observed between COVID-19 lungs and non-COVID-19 ARDS lungs. Conclusion: We posit that inflammasome formation along the vessel wall is a characteristic of lung inflammation that accompanies COVID-19. Thus, the NLRP3 inflammasome pathway seems to be probable candidate that drives amplification of inflammation post SARS-CoV-2 infection.
Lymphocyte Predominance in Blood, Pleural Fluid, and Tumour Stroma; A Prognostic Marker in Pleural Mesothelioma
Authors: Fonseka Duneesha , Arnold David T , Morley Anna J , Brett Mary , Bhatt Nidhi , Edey Anthony , Daly Richard , Bibby Anna C , Maskell Nick
Published: September 2021

Background

As promising novel treatments develop for malignant pleural mesothelioma (MPM), early prognostication has become increasingly important. Circulating and local inflammatory cells are known to play a significant role in other tumour types. We assessed the proportion of lymphocyte populations within blood, pleural fluid and tumour stroma to prognosticate patients with MPM at diagnosis.
Methods

Consecutive patients diagnosed with biopsy-proven MPM were prospectively recruited to an observational cohort study and followed up for a minimum of 7.5 years. Blood and pleural fluid results at presentation were extracted from the medical records. Biopsy specimens were independently reviewed by 2 pathologists who scored the degree of lymphocytic and neutrophilic infiltration.
Results

Baseline results were available for 184 patients. The predominant pleural fluid cell type was calculable for 84 patients and 118 patients had biopsy specimens available for review. A low blood neutrophil/lymphocyte ratio (NLR < 4) inferred a better prognosis with a median survival of 420 days versus 301 days (p < 0.01). Survival was better for patients with a lymphocyte-predominant pleural effusion (430 vs 306 days, p < 0.01). Lymphocyte infiltration of tumour stroma was also associated with improved survival (n = 92, survival 430 days) compared with neutrophilic or acellular samples (n = 26, survival 342 days p < 0.01). In multivariable modelling lymphocyte predominance in blood, pleural fluid and tumour stroma were all associated with a better prognosis.
Conclusions

Lymphocyte predominance within tumour stroma, pleural fluid or blood infers a better prognosis in patients with MPM.
Accumulation of trace element content in the lungs of Sao Paulo city residents and its correlation to lifetime exposure to air pollution
Authors: santos Nathalia Villa , Vieira Carolina Leticia Zilli , Saldiva Paulo Hilario Nascimento , De Andre Carmen Diva Saldiva , Mazzilli Barbara Paci , Andrade Maria de Fatima , Saueia Catia Heloisa , Saiki Mitiko , Veras Mariana Matera , Koutrakis Petros
Published: September 2021

Heavy metals are natural and essential elements of the environment and living beings, produced from natural (e.g. volcanic activity and cosmic ray-induced spallation) and anthropogenic processes (e.g. industrial and fossil fuel combustion). Studies showed increase of heavy metal and Polonium-210 concentrations in lung autopsies linked to urban and industrial air pollution. In this preliminary study, we analyzed the levels of heavy metals and Polonium-210 (210Po) in lung tissues in autopsies from residents of the city of Sao Paulo, SP, Brazil. In order to identify the generating sources of the heavy metals in lung a factor analysis was performed. Of the first four factors, which explain 66% of the total variability, three were associated with vehicular sources. The fitting of a regression model with Polonium-210 as the response variable and with the four factors as explanatory variables, controlling for age, sex and tobacco, showed a significant association between the concentration of polonium and the first factor that is generated by catalysts and brakes (coefficient = 0.90, standard error = 0.33, p = 0.016). Our findings suggest an association between the metals trace, from air pollution, and Polonium-210 in lung autopsies.
Curcumin Attenuates Hepato-, and Nephrotoxicity Induced by Cypermethrin Through Inhibition of Oxidative Stress in Male Albino Rabbits
Authors: Rehman Hamid , Naveed Muhammad , Ahmad Khurshid , Iqbal Mazhar , Yousaf Sohail , Jamil Muhammad , Imtiaz Hifza , Khan Hidyat , Naeem Rehan
Published: September 2021

The reactive oxygen species (ROS) have been involved in the toxicity of several pesticides. This study was aimed to induce oxidative stress in rabbit’s liver and kidney by cypermethrin (CYP), a type II pyrethroid pesticide and to evaluate the protective effect of Curcumin (CMN). Numerous plant moieties are identified to exhibit protective potential by neutralizing the oxidative stress. In this study we evaluated the protective role of powdered dried rhizome of curcuma longa L. (CMN) against CYP-induced liver and renal toxicity. For this purpose, all the rabbits were divided in 4 groups, each containing 5 rabbits. The 1st group considered as control while 2nd, 3rd and 4th group were treated with CYP (25mg/kg), CMN (50 mg/kg) alone and CYP (25 mg/kg) in combination with CMN (50 mg/kg), respectively. Biochemical markers were investigated in serum while antioxidant potential and histopathological analysis was performed in liver and kidney tissues. CYP administration resulted in significant reduction of antioxidant protein and enzymes (GSH, GST, catalase, SOD and GPx). Moreover, remarkable variations were observed in biochemical markers (urea, creatinine, AST, ALT, ALP and bilirubin) as well as in histology of kidney and liver in CYP-treated rabbits. The administration of CMN in combination with CYP significantly restored the level of endogenous antioxidants. Furthermore, the normal level of serum biochemical markers was observed with normal histology of liver and kidney in rabbits treated with CMN. Similarly, CMN alleviated the harmful effects of CYP on lipid profiles, hematological parameters and body weight of rabbits.
The Impact of Waist Circumference on Incident of Cardiovascular Death During 9 Years of Follow Up in General Population
Authors: Li Man , Wang Shu-xia , Su Yong-kang , Sun Jin , Zhang An-hang , Cheng Bo-kai , Cai Shuang , Ping Zhu
Published: September 2021

Background: Risk assessment is essential for the primary prevention of cardiovascular death among general population. Although studies have shown that waist circumference (WC) is positively associated with an increased risk of cardiovascular death among the general population, few studies have investigated the prognostic value of WC during a long-term follow up and the risk threshold of WC remains controversial. We aimed to investigate whether higher level of WC measurements was able to predict mortality in general population.Methods: In this prospective cohort study, a total of 1521 consecutive subjects free of clinical cardiovascular disease were included. The end point was cardiovascular death. The Kaplan-Meier method was used to evaluate the cumulative risk of outcome at different WC levels, and compared by log-rank tests. Univariate and multivariable-adjusted Cox regression models were used to investigate the association between WC and outcomes.Results: During a median follow up of 9.2 years, there were 265 patients died. Kaplan-Meier survival estimates indicated that the patients with higher levels of WC (WC> 94cm) had a significantly increased risk of cardiovascular death (log-rank p＜0.001). After adjustment for potential confounders, multiple COX regression models showed that higher level of WC was an independent predictor in developing cardiovascular death (HR 3.02; 95% CI: 1.88–3.83; p＜0.001). We saw a significant increase of (area under the curve) AUC in ROC (receiver operating characteristic) curve after addition of WC to a clinical model, for long-term cardiovascular death the increase of AUC 0.766 vs 0.642 (95% CI: 0.787–0.846 p＜0.001). The addition of WC to established risk factors significantly improved risk prediction of cardiovascular death (net reclassification index, and integrated discrimination improvement, all p＜0.05).Conclusion: Higher level of WC is significantly associated with long-term cardiovascular death. WC may provide incremental prognostic value beyond traditional risks factors.
Synthesis of Alamandine Glycoside Analogues as New Drug Candidates to Antagonize the MrgD Receptor for Pain Relief
Authors: Alabsi Wafaa , Jaynes Timothy , Alqahtani Tariq , Szabo Lajos , Sun Daekyu , Vanderah Todd W. , Mansour Heidi M. , Polt Robin
Published: September 2021

Two series of putatively brain-penetrant alamandine glycosides have been prepared for screening against the MrgD receptor. One series has retained the first 6 residues of the alamandine sequence (ARVYIH), replacing the terminal proline (P) with serine (S) glycosides at the C-terminus. In the second series, the alteration of the steric bulk was performed by changing the initial alanine (A) residue with glycine (G); D-alanine (a); nor-valine (norV); D-nor-valine (D-norV); valine (V); and D-nor-valine (v) with keeping the serine-beta-D-glucoside (S-Glc) at the C-terminus. All the peptides and glycopeptides were synthesized as their C-terminal amide. The purity of native alamandine and its eleven selected derivatives was confirmed using analytical HPLC. Also, the molecular weight and chemical composition were confirmed using mass spectroscopy. The MrgD receptor expression was evaluated in rationally chosen human cell lines, A549 and HEK 293. Both cell lines showed the presence of the MrgD receptor around 35 kDa, as confirmed by western blot analysis. The effect of varying concentrations of some alamandine derivatives on cell viability was evaluated on HEK 293 and A549 cell lines.
Neutrons “101” – A Primer for Earth Scientists
Authors: Ross Nancy L. , Cole David R.
Published: September 2021

The fundamental properties of the neutron make it a powerful tool for Earth science investigations because neutrons provide information that cannot be obtained by any other research method. This is because neutrons are magnetically sensitive, nondestructive, and sensitive to the lighter elements, such as hydrogen. They provide a unique, nondestructive method for obtaining information ranging from Ångstrom-scale atomic structures (and related motions) to micron-scale material strain, stress, and texture, and even up to meso-scale porous matrices and defects in materials and functional components. In this article, we introduce neutrons and their unique properties, neutron production and sources, and provide an overview of the different types of neutron methods applicable to the Earth sciences.
Where is the Hydrogen?
Authors: Gatta G. Diego , Hradil Klaudia , Meven Martin
Published: September 2021

How is hydrogen distributed among minerals and how is it bonded in their crystal structures? These are important questions, because the amount of hydrogen and the bonding configuration of hydrogen in crystalline materials governs many of that material’s properties: its thermal and compressional behavior, P–T phase stability, rheology, and electrical conductivity. A reliable reconstruction of the Earth’s interior, or the prediction of mineral transformations in complex industrial processes, must account for these parameters. Neutron diffraction can locate hydrogen sites in mineral structures, reveal any static or dynamic hydrogen disorder, help define the libration regime of hydrogen, and elucidate hydrogen-bonding configurations. Thus, that most elusive element for X-ray probes is perfectly detectable using neutrons.
Nanoscale Structure and Dynamics in Geochemical Systems
Authors: Stack Andrew G. , Wang Hsiu-Wen , Cole David R.
Published: September 2021

Neutron scattering is a powerful tool to elucidate the structure and dynamics of systems that are important to geochemists, including ion association in complex aqueous solutions, solvent-exchange reactions at mineral–water interfaces, and reaction and transport of fluids in nanoporous materials. This article focusses on three techniques: neutron diffraction, which can reveal the atomic-level structure of aqueous solutions and solids; quasi-elastic neutron scattering, which measures the diffusional dynamics at mineral–water interfaces; and small-angle neutron scattering, which can show how properties of nanoporous systems change during gas, liquid, and solute imbibition and reaction. The usefulness and applicability of the experimental results are extended by rigorous comparison to computational simulations.
Digital payment system innovations: A marketing perspective on intention and actual use in the retail sector
Authors: Chaveesuk Singha , Khalid Bilal , Chaiyasoonthorn Wornchanok
Published: September 2021

This study empirically investigated the marketing perspectives of behavioral intention and the actual use of digital payment solutions as electronic innovation for retail purchases in Thailand. This is important as leveraging digital innovation can be applied to minimize physical contact between retailers and customers, especially in the COVID-19 era. The UTAUT model was used and extended to include attitude, social distancing, and perceived risk variables. The study was conducted using primary data collected from 467 Thai respondents who used digital payment systems as a means of payment in retail purchases. The study data were collected employing a structured questionnaire. Techniques used in data analysis include Confirmatory Factor Analysis and Structural Equation Modeling. The results from the data analysis highlighted that behavioral intention to use digital payment innovation in Thailand was influenced by Perceived Risk (PR), Facilitating Condition (FC), Performance Expectancy (PE), and Attitudes (AT) of people. The study also revealed that exploring the marketing perspectives, Behavioral Intention (BI) significantly influenced the Actual Use (AU) of digital payment systems. The implication is that stakeholders in retail and financial sectors, such as banks and other digital payment providers, should consider aspects of people’s attitudes and perceived risk as they influence the use and adoption of innovative digital payment solutions. Thus, it is, appropriate to propose policies and regulations that promote the effective use of digital payment systems in the Thai retail sector.
Acknowledgment This work is supported by King Mongkut’s Institute of Technology Ladkrabang.
THE SIGNIFICANCE OF ORIENTATION OF BLIND PUPILS TO THEIR BODY IN REGARD TO MOBILITY AND SPACE ORIENTATION
Authors:   Faculty of Education and Rehabilitation, University of Tuzla, Teskeredžić Amela
Published: September 2021

Independent and safe movement includes the development of motor skills, the acquisition of basic concepts, the awareness of oneself and the awareness of the environment. The aim of the research was to determine the influence and significance of the orientation to the body of blind students, on orientation and mobility. The sample consisted of 30 blind students aged 7 to 15, placed in the internal accommodation of the Center for Children and Youth with Developmental Disabilities "Budućnost" in Derventa and the Center for Blind and Visually Impaired Children and Youth in Sarajevo. The research used an instrument for assessing the ability of the mobility of the blind, which established the initial and final levels of development of the ability to orientate towards one's own body and the mobility of blind students. For statistical data processing, descriptive statistics and t-test methods were used. The results are in favor of the final measurement, that is, after the treatment was carried out, the improvement of the orientation towards the body was determined, which influenced the orientation and mobility of the blind pupils.
Intelectuais em Diálogo
Authors: Muniz Thamyris Rodrigues , Tanus Gustavo
Published: September 2021

Recensão da obra Construindo movimentos: uma conversa em tempos de pandemia, de Angela Davis e Naomi Klein (2020).
The Use of Lectins as Tools to Combat SARS-CoV-2
Authors: Martinez Daniela , Amaral Diego , Markovitz David , Pinto Luciano
Published: September 2021

Background:

In December 2019, China announced the first case of an infection caused by an, until
then, unknown virus: SARS-CoV-2. Since then, researchers have been looking for viable alternatives for the
treatment and/or cure of viral infection. Among the possible complementary solutions are lectins, proteins that
are reversibly bound to different carbohydrates. The Spike protein, present on the viral surface, can interact
with different cell receptors: ACE2, CD147, and DC-SIGNR. Since lectins have an affinity for different carbohydrates,
the binding with the glycosylated cell receptors represents a possibility of preventing the virus from
binding to the receptors of host cells.

Objective:

In this review, we discuss the main lectins that are possible candidates for use in the treatment of
Covid-19, highlighting those that have already demonstrated antiviral activity in vivo and in vitro, including
mannose-binding lectin, Griffithsin, BanLec, and others. We also aim to discuss the possible mechanism of action
of lectins, which appears to occur through the mediation of viral fusion in host cells, by binding of lectins
to glycosylated receptors found in human cells and/or binding of these proteins with the spike glycoprotein, present
in virus surface. Moreover, we discuss the use of lectins in clinical practice.

Conclusion:

Even with the development of effective vaccines, new cases of viral infection with the same virus,
or new outbreaks with different viruses can occur; so, the development of new treatments should not be discarded.
Moreover, the discussions made in this work are relevant regarding the anti-viral properties of lectins.
In vitro Metabolism of Humantenine in Liver Microsomes from Human, Pig, Goat and Rat
Authors: Huang Si-Juan , Zuo Meng-Ting , Qi Xue-Jia , Ma Xiao , Wang Zi-Yuan , Liu Zhao-Ying
Published: September 2021

Background:

Gelsemium elegans Benth（G. elegans） is a well-known toxic plant. Alkaloids are main active components of G. elegans. Currently, the metabolism of several alkaloids, such as gelsenicine, koumine, and gelsemine, has been widely studied. However, as one of the most important alkaloids in G. elegans, the metabolism of humantenine has not been studied yet.

Methods:

In order to elaborate on the in vitro metabolism of humantenine, a comparative analysis of its metabolic profile in human, pig, goat and rat liver microsomes was carried out using high-performance chromatography/quadrupole time-of-flight mass spectrometry (HPLC/QqTOF-MS) for the first time.

Results:

Totally, ten metabolites of humantenine were identified in liver microsomes from human (HLMs), pig (PLMs), goat (GLMs) and rat (RLMs) based on the accurate MS/MS spectra. Five metabolic pathways of humantenine, including demethylation, dehydrogenation, oxidation, dehydrogenation and oxidation, and demethylation and oxidation, were proposed in this study. There were qualitative and quantitative species differences in the metabolism of humantenine among the four species.

Conclusions:

The in vitro metabolism of humantenine in HLMs, PLMs, GLMs and RLMs was studied by a sensitive and specific detection method based on HPLC/QqTOF-MS. The results indicated that there were species-related differences in the metabolism of humantenine. This work might be of great significance for the further research and explanation of species differences in terms of toxicological effects of G. elegans.
Cancer Pain: An Analysis of the Quality, Content and Readability of Information on the Internet”
Authors: BALTA Selin
Published: September 2021

Background: Pain develops in 39.3%–66.4% of cancer patients. Cancer pain decreases the patient’s quality of life and causes mood disorders; however, the patient’s access to healthcare information may improve these problems. It has been shown that 79% of cancer patients use the internet to access health information. The internet helps patients in making informed decisions concerning their treatment. This study aimed to evaluate the readability levels, content, and quality of patient information texts on Turkish websites regarding cancer pain. Methods: The texts were transferred to the readability calculation engine and the results were obtained according to the Ateşman and Bezirci-Yılmaz formulas. The content of the patient information texts on the websites was evaluated by the author. The texts were also evaluated in terms of quality by the DISCERN tool. Results: The mean value of the Ateşman formula was 47.74 ± 10.39 and compatible with being difficult to read. The result of the Bezirci-Yılmaz formula was 13.28 ± 3.53 and compatible with a license degree. The mean value of the total DISCERN score was 29.13 ± 6.26. Conclusion: Turkish healthcare information articles about cancer pain on the internet were not suitable for the education level of our society. The articles were insufficient in terms of content and comply with having a poor quality. Therefore, they could not meet the needs of the patients. A better relationship between the patient and physician may be achieved by improving the readability of health information texts on the internet and ensuring that its content is sufficient and reliable. In this manner, the success of the treatment may be improved and the results of any undertreatment may be minimized.
The Discovery of Coronavirus – An Interesting Journey
Authors: Bhattacharya Kaushik , Bhattacharya Neela , Bhattacharya Aditya Shikar
Published: September 2021

The coronavirus, which is causing the ongoing Covid-19 pandemic and has crippled the entire world, was discovered by June Dalziel Almeida - a school dropout from Scotland who had no formal medical education. She had to master the knowhow of immune electron microscopy to climb up the academic ladder and she finally discovered the coronavirus only to see her research paper getting rejected by reputed journals. A single mother is now associated with the coronavirus, as well as with a significant contribution to the classification of viruses, viral imaging and bringing Rubella virus, Hepatitis B virus and Human immunodeficiency virus into the limelight.
Investigación de mercados para la reacreditación del programa de derecho de la Universidad Autónoma Del Caribe
Authors:   Universidad Autónoma del Caribe, Pérez Juliana , Caballero Nieto Iraida ,   Universidad Autónoma del Caribe
Published: September 2021

Objetivo: El propósito del presente artículo es determinar la pertinencia actual del programa de Derecho de la Facultad de Jurisprudencia de la Universidad Autónoma del Caribe, que sirva como insumo para su proceso de reacreditación. Metodología: Para esta investigación con enfoque mixto, a través de un método descriptivo y un diseño transversal. Donde se realizaron encuestas aplicadas a los estudiantes de Educación Media del Grado 11, así como también a los estudiantes de Pregrado de la Facultad de Jurisprudencia de la UAC; asimismo, se realizó entrevistas a profundidad a diferentes egresados de la UAC y a profesionales de otras organizaciones. Resultados: demuestran la importancia que el plan de estudio posee y además que existe la pertinencia y coherencia a las necesidades actuales del país; como también la existencia de una gran oferta competitiva tanto local como nacional dándole una gran responsabilidad a la Universidad Autónoma del Caribe para poder ser Líder en este campo
Descripción de la situación actual del sistema logístico en la región caribe colombiana
Authors:   Universidad Simón Bolívar, Rodríguez Ronald , Landazury Villalba Luis Fernando ,   Universidad Simón Bolívar
Published: September 2021

El propósito principal de esta investigación es describir la situación actual del sistema logístico en la Región Caribe colombiana. Se trata de una apuesta de futuro, con grandes implicaciones en el desarrollo empresarial, tecnológico y, por tanto, económico de la Región Caribe, que se desea concretar en la construcción de las plataformas logísticas y en el funcionamiento de los puertos secos vinculados al tráfico ferroviario y otros centros logísticos, se encontró que el desarrollo del sector de la logística está íntimamente vinculado al reto que supone establecer unas comunicaciones transfronterizas en los países de la región circundante a Colombia, así mismo se relaciona con la mejora de las comunicaciones carreteables. En conclusión, la logística y la mejora de las comunicaciones son una ayuda para las empresas que desean internacionalizarse y mejorar su competitividad, ya que favorecen los intercambios económicos y estimulan las relaciones empresariales.
La base gravable del impuesto a las ventas, siempre especial
Authors:   Universidad del Atlántico, Hernández Belaides Hernán José
Published: September 2021

La base gravable del impuesto a las ventas constituye un laberinto normativo generado por la diversidad de bases gravables en este gravamen. Si bien es cierto que sólo se enuncia una base gravable especial del IVA en el Estatuto Tributario, también lo es que, cada transacción, tiene y requiere, de la exacta determinación de una base gravable especial para la correcta liquidación del impuesto, por tanto, esta investigación pretende poner de presente la importancia que reviste la asunción de las bases gravables para causar el impuesto. La metodología utilizada es la deductiva mediante el análisis de las normas y leyes que regularizan el impuesto a las ventas y documentos y jurisprudencias asociadas al tema tratado.
Calidad de la Gerencia: un análisis bibliométrico
Authors:   Corporación Universitaria Americana, Gonzalez Beleño Carlos , Rodríguez Arias Carlos ,   Universidad Tecnológica de Bolívar
Published: September 2021

La calidad de la gerencia se ha relacionado con distintas teorías administrativas y organizacionales. Este artículo de investigación tiene por objetivo realizar un análisis temporal que evidencie cómo se ha relacionado el concepto de calidad de la gerencia con conceptos y teorías administrativas a través del tiempo además de conocer aquellos autores relevantes en cada periodo analizado. Los resultados muestran que en cuanto a las temáticas relacionadas a calidad de la gerencia se han mantenido, a su vez a partir de cierto periodo prepondera como autor relevante Schroeder.
Almacenamiento de talla mundial: Aspecto clave de la competitividad para las ciudades
Authors:   Universidad Libre, Boyano Fram Teófilo Omar , Machado Licona Jhorquis ,   Corporación Universitaria Rafael Núñez
Published: September 2021

Este manuscrito hace una revisión de aspectos claves del almacenamiento, las dinámicas a las que se enfrentan en la cadena logística y las aplicaciones implementadas por grandes compañías para el manejo de adecuado de la logística de almacenamiento; la metodología utilizada es cualitativa con paradigma interpretativo y enfoque etnometodológico, a través de este se observan los elementos distintivos de las prácticas de logística de almacenamiento a nivel mundial; las principales conclusiones alcanzada indican que aunque exista el método just in time, es inevitable que existen situaciones en las cuales sea necesario apalancarse de la logística de almacenamiento, por tal motivo el almacenamiento es una actividad que tiene gran repercusión en el desarrollo de la cadena logística. Colombia afronta grandes retos que le impulsan a la modernización tanto técnica como tecnológica, por lo cual es necesario la adquisición de conocimientos en torno a las mejores prácticas logísticas, a la par de ello surge la necesidad de actualizar la tecnología de sus puertos
Unity, Continuity, Structure, and Function. The Ongoing Search for a Deeper Understanding of the Many Roles Attributed to Fascia in the Living Human Body - An Osteopathic Perspective
Authors:   Osteopathic Centre, 1732 Voie Aurelienne, 13450 Grans, France, Armstrong Colin
Published: September 2021

Progress in technologies, notably in vivo and in situ methods, has equipped scientists with the necessary skills to explore the living human body in increasingly minute detail. This has led to a better understanding of the dynamic interplay between the various elements that make up the living human body. To further understand the interplay, this research focuses on the insights and observations of the founders of osteopathy, who placed great importance on the role of fascia in the body. Modern anatomical investigation still relies heavily on dissection to describe the structural organization of living organisms. Therefore, at present, a major challenge faced by modern anatomists is to move towards a more holistic and integrative understanding of the unity, continuity, and dynamic interplay between the various elements that come together to create the living human form.