bluuebunny/crossref_metadata_2025 huggingface dataset:
Ophthalmic Zoster, A Rare Pathology in a Child
Authors: Mbodj Mohameth , Seck Ndiogou , Ndiaye Serigne Tawa , Bop Khadim , Sow Papa Souleye , Diagne Ibrahima
Published: January 2023

Herpes zoster in children is rare and particularly the ophthalmic form, which can be responsible for serious ocular complications. We report the case of a 6-year-old female patient with herpes zoster ophthalmicus. The patient was 6 years old and hospitalised with a painful rash. The examination revealed an infectious syndrome, a painful vesicular rash, in a cluster, resting on an erythematous background located on the forehead and the root of the nose with eyelid edema. Slit lamp examination came back normal. The diagnosis of herpes zoster ophthalmicus was made on the basis of clinical findings. The course was favourable on acyclovir with no ocular complications and no post-herpetic pain.
Motor Neuron Disease: To Identify the Mimics and Chameleons at the Early Stage
Authors: Ekladious Adel , Jiang Beisi
Published: January 2023

Motor neuron disease is a devastating progressive neurodegenerative disease, which is irreversible. Delay in the diagnosis is the norm among neurologists and other medical practitioners. It can affect both central and peripheral nervous systems. It also manifests by upper neuron, lower motor neuron signs or a mix of the above two and can affect the bulbar system. Because the disease is primary progressive, it mimics many other neurological deficits at different stages. Unfortunately, there is no one test to confirm the diagnosis at the early stage, typically during the first 12 months. Probably, all the differential diagnosis that reversible and treatable should be ruled out specifically. Patient may be referred to different specialities before being referred to general neurologist. Furthermore, general neurologist may need to refer the patient to motor neuron specialist; motor neuron specialist would like to make sure that he eliminated all the mimics before breaking the bad news with the patient and family that the motor neuron disease is the most probable diagnosis. It is of paramount important that the patient received the diagnosis as early as possible so he/she can benefit from multidisciplinary and interdisciplinary care team and to alleviate his/her symptoms and also to arrange advanced care planning, and assessment of ceiling of the goals of the care. It is of note that currently, patient may benefit from assisting dying if he/she fulfills the criteria. This review aims to include most common mimics and chameleons in the clinical practice and to discuss the diagnostic tools that should be performed for those who has been considered possible motor neuron disease. And to discuss the avenue for assessment by multidisciplinary care team which includes general neurologist, motor neuron specialist, respiratory physician, gastroenterologist, psychologist and psychiatrist, general physician, and allied health.
Cross-Sectional Shape Comparison In Corrugated Plates
Authors: Savran Efe , Cakarer Cagatay , Sener Fevzi Berkay , Karpat Fatih
Published: January 2023

Corrugated sheets are sheet parts used in various applications. The shapes of parts are dominators in mechanical behavior. Structural reliability is related to the ability of the structure to remain within the desired range of stress and deformation values according to the load type. The use of corrugated plates on platforms for load-bearing both prevents the use of thick materials for strength and ensures that the structure created is light. In this study, corrugated plate samples that have 100 mm width and 2 mm thickness were comthepared by the finite element method. Corrugated plate models such as pentagon, circle, supported rectangle, rectangle, square, saw, and trapeze were designed and evaluated under 20 kg load that was t applied on the surface of 50 mm width. Results showed that the trapeze model is the most rigid and circle has the least stress value model. The study revealed the effect of the corrugate model on the structural strength for plates, which are frequently used in industrial applications.
External And Internal Factors Affecting Growth and Sex Differentiation in European Eels, anguilla Anguilla
Authors: Degani Gad
Published: January 2023

Many biological and environmental aspects are involved in growth and development, including internal and external parameters and their interactions. In this mini-review, the relationship between environmental conditions and growth is described, as well as the hormones involved in growth and sex differentiation in the European eel, Anguilla anguilla. A model is proposed which describes the relationship between growth, sex hormones, environment and sex determination. Some important results that support the proposed model are presented.
Automedicação Durante a Pandemia de COVID-19 e Fatores Associados
Authors: Branco Letícia Lima , Lobato Micaella Yanne Fender , Borges José Felipe Teixeira , Oliveira Rita de Cássia Silva de
Published: January 2023

Durante a pandemia da COVID-19, a automedicação se intensificou devido a diversos fatores, como a facilidade de obtenção de medicamentos sem receita médica, a dificuldade de acesso aos serviços de saúde e a ampla divulgação midiática de fármacos de venda livre para a população. Diante disso, o presente estudo objetivou avaliar a prevalência e fatores associados à automedicação na pandemia de COVID-19. A obtenção de dados ocorreu por meio da aplicação de um questionário sobre a prática de automedicação durante a pandemia por COVID-19. O questionário online foi enviado para indivíduos com 18 anos ou mais, residentes da região metropolitana de Belém. Dessa forma, obteve-se uma totalidade de 273 respostas válidas. A partir da avaliação dos dados, notou-se prevalência da prática no sexo feminino, em adultos jovens e indivíduos sem o ensino superior. Ademais, entre os medicamentos utilizados, destacam-se os analgésicos não opioides e Anti-inflamatórios Não Esteroidais (AINEs). De posse desses e de outros dados, políticas públicas podem ser pensadas para minimizar a prática da automedicação descontrolada, evitando o surgimento de efeitos adversos pelo uso irracional de fármacos, principalmente durante situações de grande risco a saúde pública.
Perancangan Video Dokumenter Kuliner Legendaris di Kota Malang
Authors: Wijaya Stefanus , Nugroho Didit Prasetyo
Published: January 2023

Kota Malang merupakan kota wisata yang cukup terkenal baik karena wisata alam dan juga wisata kulinernya. Ada banyak tempat kuliner di Kota Malang yang telah berdiri lebih dari 50 tahun dan menjadi legendaris. Tetapi meskipun demikian, kurangnya upaya pelestarian dan pengetahuan akan membuat tempat-tempat kuliner legendaris ini lambat laun menjadi dilupakan. Maka dari itu terdapat media alternatif yang tepat untuk digunakan sebagai sarana pengenalan tempat-tempat kuliner legendaris ini, salah satunya adalah video dokumenter. Metode yang digunakan adalah metode kualitatif. Pengumpulan data kualitatif yang dilakukan adalah observasi, wawancara, dan dokumentasi. Perancangan ini menghasilkan media utama berupa video dokumenter yang berjudul “Legenda Kuliner Malang: Ragam Rasa Ragam Budaya” dengan durasi 8 menit 44 detik dan teaser dengan durasi 32 detik. konsep yang diangkut adalah menggambarkan hubungan antara budaya dan kuliner. Serta media pendukung berupa x-banner, cover dan CD label, topi, totebag, stiker, kaos, dan postcard.
“Asat” Seni Video Instalasi
Authors: Nugroho Heri
Published: January 2023

“Asat” adalah kata yang diambil dari bahasa Jawa yang berarti kering. “ASAT” digunakan sebagai judul pada seni video instalasi ini. Karya seni ini berdurasi 4 menit hingga 5 menit yang disajikan dengan teknik looping. Karya seni visual ini adalah sebuah instalasi sumur tradisional yang disatukan dengan video diproyeksikan menggunakan proyektor optik video ke dalam instalasi lubang sumur kemudian disajikan langsung kepada penonton. Sehingga setiap penonton yang menonton karya seni ini meluhat kedalam lubang sumur seperti pada sumur sesungguhnya. Konsep visual dari video yang diproyeksikan ke instalasi membuat perspektif nyata sumur.

Bekaitan dengan masalah lingkungan yang merupakan kerusakan lingkungan kekeringan akibat ulah manusia yang tidak melindungi lingkungannya dengan Hotel, Mall, Apartemen dan bangunan besar lainnya yang merusak lingkungan, membuat sumur-sumur di sekitar menjadi kering. Dengan proses visualisasi mengeringkan sumur dengan tanda di visual video, setiap penonton dituntun untuk ikut merasakan bagaiman proses kerusakan lingkungan yang terjadi di sekitarnya, juga efek yang didapat dari kerusakan tersebut. Konsep video instalasi dipilih untuk penciptaan karya ini, bertujuan untuk menciptakan hubungan yang erat antara penonton dengan karya seni, sehingga spekulasi nyata akan terasa oleh setiap masyarakat, sehingga akan menciptakan emosi yang mendalam kepada para penonton yang menikmati karya seni ini. Melalui karya seni ini dengan segala konsepnya sehingga karya ini memiliki peran yang besar dalam menyampaikan pesan moral kepada para penonton untuk selalu menjaga lingkungannya agar dapat menjaga keberlangsungan kehidupan setiap makhluk di bumi.
Produksi Film Dokumenter Kain Tenun Ikat Sumba Timur dengan Menggunakan Teknik Sinematografi Extreme Close-Up
Authors: Lius Jonathan Febrian
Published: January 2023

East Sumba has a great potential for natural and cultural tourism. Currently, East Sumba is one of the potential tourist attractions that appeals for both domestic and foreign tourists to come and visit the region of East Nusa Tenggara, particularly Sumba Island. In addition to natural tourism, East Sumba also possesses an iconic commodity that is also an ancestral heritage, which is the kain tenun ikat woven fabric of East Sumba. With currently existing technologies, people have become more facilitated in seeking information. In a documentary video, the angle of shooting utilized the extreme close-up cinematography technique in certain parts of the creation process for the kain tenun. The shooting of the film with the extreme close-up technique is expected to be able to bring out or enhance the details of the creation process for the kain tenun ikat of East Sumba. The documentary film that shows the process of making the kain tenun ikat of East Sumba is expected to become a film that can engage the interests of youths and local tourists to learn about and participate in preserving the cultural heritage of the kain tenun ikat from East Sumba.
Perancangan Video Pembelajaran 3D Modeling Berbasis Schoology Untuk Mahasiswa DKV Ma Chung
Authors: Kurniawan Daniel Chandra , Rahmadianto Sultan Arif , Nugroho Didit Prasetyo
Published: January 2023

Saat ini dunia sedang memasuki era revolusi industri 4.0, dimana teknologi sudah menjadi bagian dari kehidupan manusia. Dalam dunia pendidikan, perkembangan internet dan teknologi yang semakin pesat mendorong upaya pembaharuan dalam pembelajaran. Masalah yang diidentifikasi salah satunya adalah pembelajaran 3D modeling DKV Ma Chung masih konvensional dan belum mengadaptasi pembelajaran di era revolusi industri 4.0.

Metode yang digunakan adalah penelitian pengembangan (Research and Development) dengan model penelitian pengembangan versi ADDIE. Adapun tahapan tersebut yaitu: Analysis, Design, Development, dan Implementation. Tahapan development menggunakan tahapan dalam produksi video yaitu pra produksi, produksi, dan paska produksi. Hasil akhir dari penelitian ini adalah produk video pembelajaran 3D modeling berbasis Schoology untuk mahasiswa DKV Ma Chung. Kelayakan produk dapat dilihat dari hasil penilaian ahli materi dengan angka presentase sebesar 85% yang dikategorikan sangat layak. Hasil penilaian ahli media dengan angka presentase sebesar 88% yang dikategorikan sangat layak. Penilaian produk oleh mahasiswa mendapatkan angka presentase sebesar 88% yang dikategorikan sangat baik.
Analisis Visual Cover Majalah Bobo Tahun 2015
Authors: Prasetyo Abdul Rahman , Rahmawati Nila , Kusumanada Ayu Pramudya
Published: January 2023

Majalah Bobo merupakan majalah khusus anak-anak legendaris di Indonesia. Cover Majalah Bobo memiliki daya tarik dan karakter yang kuat sehingga mudah dikenali oleh pembaca. Penelitian ini bertujuan untuk mengetahui lebih detail tentang standar desain visual meliputi ilustrasi, warna, tipografi, dan layout cover Majalah Bobo Edisi Khusus Tahun 2015. Penelitian ini menggunakan metode kualitatif deskriptif. Hasil penelitian menunjukkan bahwa pada cover majalah Bobo edisi khusus tahun 2015 menggunakan ilustrasi digital dengan tokoh kelinci yang dipersonifikasikan sebagai bentuk manusia. Tipografi yang digunakan berupa jenis font Fantasy dan San Serif. Warna yang disajikan tergolong full color, mencolok, cerah dan terkesan tidak suram. Layout diposisikan asimetris namun tetap menerapkan prinsip kesatuan(unity), keseimbangan (balance), irama (ritme), dan penekanan (emphasis). Kesimpulan pada penelitian ini adalah Bobo memiliki ciri khas berupa ilustrasi kelinci yang dipersonifikasikan sebagai manusia bernama Bobo yang menjadi tokoh utama pada setiap edisinya. Selain itu, ciri khas lainnya berupa bentuk logo/nameplate, font yang sama pada setiap edisi kecuali headline. Slogan “Teman Bermain dan Belajar” juga merupakan ciri khas yang terdapat pada Majalah Bobo. Warna yang digunakan juga sesuai dengan usia anak-anak yang menyukai warna-warna yang colorfull, mencolok dan cerah.
Perancangan Buku GSM Konten Kreatif Instagram Nagoya Barbershop Sebagai Media Persuasi Target Pasar Usia 19-24 Tahun di Kota Malang
Authors: Monica A'ang Sally , Prasetia Bintang Pramudya Putra
Published: January 2023

Pesatnya perkembangan media sosial banyak dimanfaatkan dalam media pemasaran di Instagram. Media ini dianggap lebih efektif karena selalu dilihat oleh semua orang dan penyebaran info lebih cepat dengan harga yang lebih murah. Media ini dipilih oleh Nagoya Barbershop untuk mengembangkan bisnisnya ditengah persaingan kompetitor. Metode yang digunakan dalam penelitian ini adalah kualitatif milik Siyoto tahun 2015 yang dapat mencari data lebih mendalam. Dalam penelitian ini, data yang dianalisa menghasilkan 9 jenis konten barbershop yang terdiri dari haircut, vibes, steal hairstyle, tips, barbershop services, promo, qna, products, dan holiday greetings yang sudah lengkap dengan Instagram Story dan Reels yang diatur dalam buku GSM. Buku ini mengatur template yang akan diterapkan pada 9 konten dan bersifat wajib. Selain itu terdapat media lain yang dapat mendukung media pemasaran seperti haircape, outer kimono, dan voucher.
The Relationship Between Mallampati Score And Obesity With the Risk of OSAHS in Down Syndrome Children
Authors: Gamayani Uni , Sihite Agnes Christine Yolanda , Pusparini Iin , Lailiyya Nushrotul
Published: January 2023

Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS) has commonly occured in Down syndrome children caused by the abnormalities in upper respiratory tract anatomy and obesity. This study aims to identify the correlation between Mallampati score and obesity and the risk of OSAHS in Down syndrome children. This was an analytical descriptive cross-sectional study. This study was conducted in children with Down syndrome from September until November 2017. All parents filled the Indonesian Pediatric Sleep Questionnaire (PSQ), then all of the children were examined for Mallampati score and BMI. The correlation was analyzed by the Pearson Chi-Square model. Thirty-six subjects were included in this study. The number of male subjects were slightly more (61.1%), the mean age of the subjects was 8.42±4,449 years, with 52.8% (19 subjects) having OSAHS. There were 23 subjects (63.9%) who had Mallampati scores of 3 and 4, with 13 subjects (36.1%) were obese. This study concluded a statistically significant correlation between Mallampati score and obesity and the risk of OSAHS in Down syndrome children (p-value 0.001 and 0.029). Mallampati score and obesity had a significant correlation with the risk of OSAHS in Down syndrome children.
Vascular Risk Factor and Cognitive Impairment in Elderly
Authors: Setiarini Rohmania , Pratiwi Made Rika Anastasia , Leonaviri Mirzaulin
Published: January 2023

The elderly are more likely to experience cognitive impairment, especially those who have a vascular risk factor. The purpose of this study was to determine the relationship between vascular risk factor and cognitive impairment in the elderly. Observational research method with cross-sectional design consist of 79 participant in Tresna Werdha Puspa Karma Social Institution, Mataram from October to November 2021. The subjects were measured blood pressure, weight and height to obtain BMI, glucose level, and total cholesterol. Furthermore, each participant underwent a cognitive function test using Moca-INA. Data were analyzed by chi-square and logistic regression. Diabetes mellitus (p =0.09), hypertension (p =0.037), lower education (p =0,01) and hight blood pressure (p =0.036) were associated with poor cognitive function.
Efficacy of Surfactant Therapy of ARDS Induced by Hydrochloric Acid Aspiration Followed by Ventilator-Induced Lung Injury – an Animal Study
Authors: MIKOLKA P , KOSUTOVA P , KOLOMAZNIK M , MATEFFY S , NEMCOVA N , MOKRA D , CALKOVSKA A
Published: January 2023

The development of acute respiratory distress syndrome (ARDS) is known to be independently attributable to aspiration-induced lung injury. Mechanical ventilation as a high pressure/volume support to maintain sufficient oxygenation of a patient could initiate ventilator-induced lung injury (VILI) and thus contribute to lung damage. Although these phenomena are rare in the clinic, they could serve as the severe experimental model of alveolar-capillary membrane deterioration. Lung collapse, diffuse inflammation, alveolar epithelial and endothelial damage, leakage of fluid into the alveoli, and subsequent inactivation of pulmonary surfactant, leading to respiratory failure. Therefore, exogenous surfactant could be considered as a therapy to restore lung function in experimental ARDS. This study aimed to investigate the effect of modified porcine surfactant in animal model of severe ARDS (P/F ratio ≤13.3 kPa) induced by intratracheal instillation of hydrochloric acid (HCl, 3 ml/kg, pH 1.25) followed by VILI (VT 20 ml/kg). Adult rabbits were divided into three groups: untreated ARDS, model treated with a bolus of poractant alfa (Curosurf®, 2.5 ml/kg, 80 mg phospholipids/ml), and healthy ventilated animals (saline), which were oxygen-ventilated for an additional 4 h. The lung function parameters, histological appearance, degree of lung edema and levels of inflammatory and oxidative markers in plasma were evaluated. Whereas surfactant therapy with poractant alfa improved lung function, attenuated inflammation and lung edema, and partially regenerated significant changes in lung architecture compared to untreated controls. This study indicates a potential of exogenous surfactant preparation in the treatment of experimental ARDS.
Mitochondrial Dysfunction in Kidney Cortex and Medulla of Subtotally Nephrectomized Rat
Authors: JEDLIČKA J , GRUNDMANOVÁ M , ŠVÍGLEROVÁ J , TŮMA Z , NALOS L , RAJDL D , ŠTENGL M , KUNCOVÁ J
Published: January 2023

Five-sixths nephrectomy is a widely used experimental model of chronic kidney disease (CKD) that is associated with severe mitochondrial dysfunction of the remnant tissue. In this study, we assessed the effect of CKD on mitochondrial respiration separately in the rat kidney cortex and medulla 10 weeks after induction of CKD by subtotal 5/6 nephrectomy (SNX). Mitochondrial oxygen consumption was evaluated on mechanically permeabilized samples of kidney cortex and medulla using high-resolution respirometry and expressed per mg of tissue wet weight or IU citrate synthase (CS) activity. Mitochondrial respiration in the renal cortex of SNX rats was significantly reduced in all measured respiratory states if expressed per unit wet weight and remained lower if recalculated per IU citrate synthase activity, i.e. per mitochondrial mass. In contrast, the profound decrease in the activity of CS in SNX medulla resulted in significantly elevated respiratory states expressing the OXPHOS capacity when Complexes I and II or II only are provided with electrons, LEAK respiration after oligomycin injection, and Complex IV-linked oxygen consumption per unit CS activity suggesting compensatory hypermetabolic state in remaining functional mitochondria that is not sufficient to fully compensate for respiratory deficit expressed per tissue mass. The results document that CKD induced by 5/6 nephrectomy in the rat is likely to cause not only mitochondrial respiratory dysfunction (in the kidney cortex), but also adaptive changes in the medulla that tend to at least partially compensate for mitochondria loss.
Xeroderma Pigmentosum: A Multidisciplinary Approach
Authors: Sethi Mieran , Lehmann Alan R. , Fassihi Hiva
Published: January 2023

Xeroderma pigmentosum (XP) is a rare, autosomal recessive disorder of DNA repair. Affected individuals are unable to repair ultraviolet radiation (UVR)-induced DNA damage, leading to a variety of clinical manifestations: a dramatic increase in mucocutaneous malignancies, increased lentigines, extreme photosensitivity (in approximately 50% of cases), and neurodegeneration (in approximately 30% of affected individuals). Incidence in Western Europe is recorded as 2.3 per million live births. There are eight different complementation groups, XP-A to XP-G, and XP-variant (XP-V) corresponding to the eight affected genes. Classically, XP patients were identified by clinicians for their tendency to develop severe and exaggerated sunburn on minimal sun exposure, however recently it has been shown that XP-C, XP-E and XP-V patients have normal sunburn reactions for skin type compared to the other groups, who suffer not only with severe, exaggerated sunburn, but also have an increased incidence of neurodegeneration.

A diagnosis of XP should be considered in a child with either severe sunburn, increasing lentigines at exposed sites, or development of multiple skin cancers at an early age. Skin biopsy and subsequent testing in cell cultures for defective DNA repair, confirms or excludes the diagnosis. Mean life expectancy is reduced; the two main causes of mortality are skin cancer and neurodegeneration. These clinical features distinguish XP from other disorders of DNA repair, namely Trichothiodystrophy and Cockayne syndrome, although overlapping syndromes do occur. Instigation of meticulous photoprotection for all XP patients has been shown to reduce both the lentigines and number of skin cancers dramatically and would be presumed to increase life expectancy. Compliance with photoprotection is a recognised problem amongst XP patients, particularly in those without easy sunburn. This is further accentuated by lack of social acceptance for people who wear UVR-protective visors. Increased awareness of XP, both within the medical and media spheres will benefit current and future XP patients; this will aid earlier diagnosis and timely photoprotection, with better compliance, and therefore, result in an improved prognosis.
Treatment of Antibody-Mediated Rejection in Kidney Transplantation
Authors: Durlik Magdalena
Published: January 2023

Antibody-mediated rejection (AMR) is a relatively rare but severe complication in kidney transplantation associated with increased risk of graft loss. Diagnosis of acute and chronic AMR is based on typical histological hallmarks, deposition of C4d in peritubular capillaries and presence of donor-specific antibodies (DSA). Many novel and attractive treatment options have become available in recent years: antibody removal and production inhibition (plasmapheresis, IVIg), B cell depletion (rituximab), plasma cell depletion and apoptosis (bortezomib), and complement activation inhibition (eculizumab). Standard therapy is based on PP and IVIg. Preliminary results with new agents are encouraging but require randomised clinical trials and long-term follow-up.
The Renal Effects of SGLT2 Inhibitors
Authors: Sawaf Hanny , Qaz Moarij , Ismail Jeeda , Mehdi Ali
Published: January 2023

Sodium–glucose co-transporter inhibitors (SGLT2i) have recently gained a lot of emphasis in their role in preventing progression of chronic kidney disease and helping with cardiac mortality. Various studies have proven the benefit of these medications in the management of patients with kidney and heart disease. SGLT2i exert their effect in the proximal convoluted tubule with various downstream effects noted in the kidney also. With spreading use of these medications, it is imperative to understand the effects they have on various electrolytes and the pathways involved in bringing about these changes in the kidney. Here, the authors review the current knowledge of SGLT2i with their effects on the kidney, electrolytes, and water balance.
Multiple Sclerosis: Where Do We Go From Here?
Authors: Tejera-Alhambra Marta , Fernández-Paredes Lidia , de Andrés Clara , Sánchez-Ramón Silvia
Published: January 2023

Multiple sclerosis (MS) is the most common cause of neurological disability in young populations after trauma and represents a significant personal, social, and economic public health burden. The clinical course and response of MS to therapy is highly heterogeneous, but most patients progress from a relapsing-remitting disease course, in which patients may respond to immunomodulatory drugs, to a steady progression and neurodegeneration that is unresponsive to any currently available treatment. In the last few years, novel disease-modifying therapies for MS have become available but the aetiology of the disease remains an enigma. The search for clinical biomarkers that are able to stratify MS patients and allow the personalisation of treatment strategies, has developed greatly in recent years though only a few have been integrated into routine clinical practice.
Current Concepts of Neurodegenerative Diseases
Authors: Kovacs Gabor G.
Published: January 2023

Neurodegenerative diseases (NDDs) are described as disorders with selective loss of neurons and distinct involvement of functional systems defining clinical presentation. Extensive studies demonstrated that proteins with altered physicochemical properties are deposited in the human brain in NDDs. The present review focuses on predominantly sporadic disorders in adulthood. Major concepts of NDDs can be summarised as follows: 1) molecular pathologic classification of NDDs is protein-based; 2) the proteinopathy concept underpins the role of protein processing systems; 3) seeding of pathological proteins supports the theory of prion-like spreading; 4) the clinical symptoms are determined by the system affected and do not unequivocally reflect the molecular pathological background; 5) overlapping of NDDs may be more the rule than the exception. Accordingly, NDD-related proteins and their biochemical modifications can be used as biomarkers and may be targeted for therapy. However, due to the high number of combinations of different proteinopathies a personalised therapy strategy may be warranted.
Yoga as Treatment for Insomnia Among Cancer Patients and Survivors: A Systematic Review
Authors: Mustian Karen M.
Published: January 2023

Between 15-90% of cancer patients and survivors report some form of insomnia or sleep quality impairment during and post-treatment, such as excessive daytime napping, difficulty falling asleep, difficulty staying asleep, and waking up too early. Insomnia and sleep quality impairment are among the most prevalent and distressing problems reported by cancer patients and survivors, and can be severe enough to increase cancer mortality. Despite the ubiquity of insomnia and sleep quality impairment, they are under-diagnosed and under-treated in cancer patients and survivors. When sleep problems are present, providers and patients are often hesitant to prescribe or take pharmaceuticals for sleep problems due to polypharmacy concerns, and cognitive behavioural therapy for insomnia can be very difficult and impractical for patients to adhere to throughout the cancer experience. Research suggests yoga is a well-tolerated exercise intervention with promising evidence for its efficacy in improving insomnia and sleep quality impairment among survivors. This article provides a systematic review of existing clinical research on the effectiveness of yoga for treating insomnia and sleep quality impairment among cancer patients and survivors.
The US experience in assessment of soils by productivity
Authors: Drebot O. , Dobriak D. , Melnyk P. , Sakharnatska L.
Published: January 2023

The article has highlighted the experience of the United States in crediting land based on productivity. In Ukraine soil classification was carried out in the section of soil groups according to their main natural properties, which have a stable nature and significantly affect the yield of agricultural crops grown in specific soil and climatic conditions. Complete work on soil grading on agricultural lands in Ukraine was carried out in 1993 within the boundaries of natural-agricultural districts and regions. Integral natural properties of soils reflect the credit score. These properties are divided into basic and modified. The main ones include the following: humus content, capacity of the humus horizon, the content of physical clay (particles up to 0.01 mm). The modified are mainly salinity, erosion, etc. Credit assessment of soil quality is presented in relative values — points on a closed 100-point scale. In contrast to Ukraine, in the United States land credit rating is carried out according to their productivity. Quantitative characterization of land productivity was carried out using two methodological approaches: inductive and deductive. The inductive assessment of productivity is given solely based on the estimated impact of different lands and soil properties on the potential yield. Deductive assessment, on the contrary, is based only on yield data on different soils. Most land valuations combine both approaches. It should be noted that thanks to the improvement of modern computer technology, it became possible to collect and process a large amount of information about land resources, which makes it possible to create mathematical simulation models, search programs, and computerized data banks. This is greatly facilitated by the development of remote sensing, new measuring devices, and map printing systems. This experience will contribute to the improvement of land resource assessment methods in Ukraine as well, despite the serious challenges that exist in the country.
Pengaruh Peran Orang Tua Terhadap Hasil Belajar Matematika Siswa Pembelajaran Tatap Muka Terbatas
Authors: Miftahur Rohmah  , Faizah Siti
Published: January 2023

Dewasa ini karena Pembelajaran dilakukan dengan tatap muka terbatas yang sesuai dengan SKB 4 menteri, maka diperlukan pengawasan orang tua ketika pembelajaran dilakukan di rumah. Orang tua memegang tanggung jawab serta peran penting untuk terlaksananya pembelajaran ini berlangsung, karena peserta didik akan lebih banyak menghabiskan waktu belajarnya di rumah bersama orang tua dan keluarga. Penelitian bertujuan guna : 1) mengetahui pengaruh peran orang tua terhadap hasil beajar Matematika Siswa ketika pembelajaran tatap muka (PTM) terbatas. 2) mengetahui besar hubungan peran orang tua pada hasil belajar Matematika siswa ketika pembelajaran tatap muka (PTM) terbatas. Penelitian ini menggunakan metode kuantitatif, dengan pengambilan 60 siswa sebagai sampel menggunakan teknik random samplling. Data dikumpulkan dengan menggunakan angket /kuisioner guna mencari data peran orang tua serta dokumentasi guna mencari data hasil belajar matematika siswa. Prosentase dan analisis regresi linier sederhana merupakan Teknik analisis data yang digunakan. Hasil dari penelitian ini menunjukkan bahwa: a) Presentase peran orang tua tergolong dalam kategori “baik” yakni sebesar 68,97%, serta peran orang tua memiliki pengaruh pada hasil belajar matematika siswa yang ditunjukkan dengan signifikansi Fhitung <Ftabel yakni 0,024 <0,05 dengan artian bahwasanya H0 ditolak dan Ha diterima. b) Besar pengaruh peranorang tua terhadap hasil belajar matematika siswa kelas 7 SMPN 5 Jombang ketika pembelajaran tatap muka terbatas yakni sebesar 8,5% serta yang 91,1% dipengaruhi faktor lain. Besarnya korelasi antara peran orang tua dan hasil belajar matematika siswa yakni 0,292. Yang memiliki artian bahwa peran orang tua mempunyai hubungan pengaruh yang “rendah” terhadap hasil belajar matematika siswa, yang ditunjukan dengan tabel interpretasi korelasi yang berada pada interval {r|0,20≤r<0,40}.
Getting a seat at the (electoral) table: Partisan poll workers and electoral bias
Authors: Duarte Raul , Carrizosa Andres
Published: January 2023

Does the partisanship of poll workers affect electoral outcomes? Many countries use partisan and adversarial vote-counting systems where poll workers are party representatives and mutual control is expected to provide fairness. Yet in countries with dominant party regimes, parties often have de facto unequal capacities to send representatives to all booths. Analyzing the 2018 general elections in Paraguay, we estimate that partisan poll workers decrease an opposing party's vote share by up to 2 percentage points (pp) and increase theirs by up to 1 pp. Our analyses also demonstrate how incentives for electoral manipulation vary by electoral system. Dominant parties' partisan poll workers collude against smaller parties more often in proportional representation races. In contrast, single-winner plurality voting yields less collusion because the winner-take-all aspect of these races make collusion difficult. Our results have practical implications for politicians and policymakers, as well as theoretical implications for elections in developing democracies.
Graphic Organizers: Mind Maps as a tool to enhance Reading Comprehension skills
Authors: Fernández Fernández M. Ángeles , Fonseca Mora María del Carmen
Published: January 2023

Reading comprehension in L2 is perhaps the skill whose requirements have changed most and most rapidly due to the demand of the information society. Readers not only need to interpret words and sentences in articles or books: sometimes they have to make a meaning out of disconnected pieces of information in pouring messages on websites, and social networks. The purpose of the present study is to explore the possibilities of mind-mapping techniques in order to foster the reading comprehension abilities in students of English as L2 by working under the assumption that the latter can be improved when apparently loose pieces of written information are connected by means of images and lines. The experiment in the project involved a total of 84 participants of two consecutive academic levels: first and second year of post-compulsory secondary education. Different sessions and two parallel procedures were scheduled in order to provide us with contrasting data that could be systematized numerically. Even though the sessions that could be scheduled were limited in number, the analysis of the data suggests some noticeable improvement in the reading comprehension abilities in most participants and some perception of progress in a majority of them. Their positive feedback, suggests that sustained work in this field could improve their reading comprehension skills in a significant way.
Perspectives of Intercultural Communication in Foreign Language Teaching and Learning
Authors: Santos-Sopena Òscar O. , Antolín Pichel Carmen
Published: January 2023

This article focuses on the intercultural approaches to teaching English as a Foreign Language (EFL) in Spain. Within communication and linguistic uses, we relate the concepts of communicative competence (Byram, 1997) to an intercultural speaker (Kramsch, 1998) with both learning and teaching at our technological educational context. These concepts will be approached from an intercultural perspective. In order to help future speakers of a language overcome above appointed issues, the idea is to set the theoretical foundation which helps us to elaborate an Academic Program bearing in mind how interculturality leads to different uses of grammar in L1 and L2. The main results will lead to adjusting EFL to current legislation, raise awareness on how interculturality is a really strong tool to understand grammar and on current limitations and further research to be done on this subject.
Agentes in Rebus в Римській імперії IV-V ст. від Р.Х.
Authors: Pukhovets Dmytro
Published: January 2023

Мета статті: дослідити корпус agentes in rebus як важливий елемент організації політичної системи Пізньої Римської імперії.

Наукова новизна: охарактеризовано особливості комплектування, організації та керівництва корпусу agentes in rebus. Проаналізовано офіційні посадові обов’язки агентів на різних етапах їхнього кар’єрного шляху. Досліджено характер неофіційних доручень, які виконували агенти. Зроблено спробу визначення того, чи можна вважати корпус agentes in rebus римською секретною службою.

Висновки. У ході проведеного дослідження проаналізовані основні особливості організації корпусу agentes in rebus. Вони були цивільними чиновниками, хоча і зберігали основи військового формування. Підпорядковувались «агенти в справах» magister officiorum, хоча при цьому мали і безпосередніх начальників. Встановлено, що імператорські кодекси виділяють три основні категорії агентів: кур’єри, які розвозили імператорські постанови по імперії; curiosi, які були інспекторами державної поштової служби; principes officii, які очолювали секретаріати провідних провінційних чиновників рівня префектів преторія та вікаріїв. Паралельно з виконанням основної роботи agentes in rebus були інформаторами, шпигунами імператорів.

Визначено, що на практиці діяльність agentes in rebus час-від-часу виходила за межі функцій, представлених в імператорському законодавстві. Регулярно агентами застосовувалась практика побиття батогами та кидання до в’язниці людей, які вважалися підозрілими. У поодиноких випадках agentes займалися розвідкою за межами держави, очолювали посольства високого рівня, брали участь в арештах і навіть вбивствах високопосадових осіб, яких держава вважала своїми ворогами.

У результаті дослідження виявлено, що в сукупності проявів своєї діяльності схола agentes in rebus мала риси секретної служби, навіть при тому, що паралельно виконувала звичайні бюрократичні завдання. Діяльність корпусу часто негативно оцінювалася сучасниками з моральної точки зору: агентів звинувачували у корупції, несправедливих доносах задля кар’єрного зростання. Але при всіх мінусах наявність такої служби була потрібна державі, вона сприяла її централізації та повноцінному функціонуванню.
Система підготовки вчительських кадрів для церковних шкіл в лівобережних українських єпархіях Російської імперії на межі ХІХ – ХХ ст.
Authors: Petrenko Iryna , Vynnychenko Ihor
Published: January 2023

Мета статті: висвітлити процес організації та підготовки вчительських кадрів для церковних шкіл у лівобережних українських єпархіях Російської імперії на межі ХІХ – ХХ ст. Зокрема, виявити та проаналізувати особливості функціонування церковно-учительських шкіл і курсів підвищення кваліфікації педагогічних кадрів шкіл духовного відомства. З’ясувати специфіку освітянської та культурницько-просвітницької діяльності православного духовенства на зламі ХІХ-ХХ ст.

Наукова новизна: із загальної теми церковної освіти окремим сегментом виділено учительський корпус, що дало змогу розглянути систему підготовки учительських кадрів. Комплексно досліджено специфіку функціонування церковно-учительських шкіл і підвищення кваліфікації у лівобережних українських єпархіях Російської імперії. Простежено механізм комплектування учительського корпусу єпархій, що дало можливість виявити тенденції еволюції складу учительства, розглянуто кадровий склад як окремий складник галузі освіти. Удосконалено та розширено загальну характеристику освітянської активності духовенства.

Висновки. На основі проведеного дослідження зроблено висновок про те, що учительський склад церковнопарафіяльних шкіл, як складник системи початкової освіти, перебував під пильним контролем церковно-шкільної адміністрації єпархій і церковно-управлінських структур. У зазначених географічних рамках лише Полтавська єпархія мала спеціальні два навчальних заклади – церковно-учительські школи (на полі Полтавської битви й у м. Лубни). Харківська губернія була знаним центром церковно-шкільної справи, яка поширювала досвід викладання Закону Божого на інші єпархії. У Чернігівській губернії на належному рівні відбувалося підвищення кваліфікації педагогічних кадрів, оскільки там учительські курси мали свою спеціалізацію: співочу, сільськогосподарську, богословську.

Церковно-вчительське шкільництво на межі ХІХ-ХХ ст. тільки розпочинало свою діяльність, і Перша світова війна та атеїстична радянська пропаганда не дали можливості виявити весь їх потенціал. За своє короткочасне існування церковно-учительські школи не встигли забезпечити належних масштабів підготовки вчителів для шкіл церковного відомства. Значна частина педагогічних кадрів церковних шкіл так і залишилася без фахової педагогічної освіти.
A novel approach for large-scale manufacturing of small extracellular vesicles from bone marrow-derived mesenchymal stromal cells using a hollow fiber bioreactor
Authors: Jakl Viktoria , Ehmele Melanie , Winkelmann Martina , Ehrenberg Simon , Eiseler Tim , Friemert Benedikt , Rojewski Markus Thomas , Schrezenmeier Hubert
Published: January 2023

Mesenchymal stromal cells (MSCs) are promising therapeutic candidates in a variety of diseases due to having immunomodulatory and pro-regenerative properties. In recent years, MSC-derived small extracellular vesicles (sEVs) have attracted increasing interest as a possible alternative to conventional cell therapy. However, translational processes of sEVs for clinical applications are still impeded by inconsistencies regarding isolation procedures and culture conditions. We systematically compared different methods for sEV isolation from conditioned media of ex vivo expanded bone marrow-derived MSCs and demonstrated considerable variability of quantity, purity, and characteristics of sEV preparations obtained by these methods. The combination of cross flow filtration with ultracentrifugation for sEV isolation resulted in sEVs with similar properties as compared to isolation by differential centrifugation combined with ultracentrifugation, the latter is still considered as gold standard for sEV isolation. In contrast, sEV isolation by a combination of precipitation with polyethylene glycol and ultracentrifugation as well as cross flow filtration and size exclusion chromatography resulted in sEVs with different characteristics, as shown by surface antigen expression patterns. The MSC culture requires a growth-promoting supplement, such as platelet lysate, which contains sEVs itself. We demonstrated that MSC culture with EV-depleted platelet lysate does not alter MSC characteristics, and conditioned media of such MSC cultures provide sEV preparations enriched for MSC-derived sEVs. The results from the systematic stepwise evaluation of various aspects were combined with culture of MSCs in a hollow fiber bioreactor. This resulted in a strategy using cross flow filtration with subsequent ultracentrifugation for sEV isolation. In conclusion, this workflow provides a semi-automated, efficient, large-scale-applicable, and good manufacturing practice (GMP)-grade approach for the generation of sEVs for clinical use. The use of EV-depleted platelet lysate is an option to further increase the purity of MSC-derived sEVs.
Functions and relevance of spatial co-presence: Lessons learned from the COVID-19 pandemic for evidence-based workplace and human capital management
Authors: Windlinger Lukas , Gerber Marius
Published: January 2023

Introduction: This study aims to analyze the role of co-presence against the background of COVID-19 pandemic to derive implications for an interdisciplinary, evidence-based workplace and human capital management. A theoretical framework is outlined that considers a range of topics from task performance to social and organizational contextual factors.

Methods: In a single organization qualitative case study, five focus group interviews including a total of 20 employees of an IT consultancy were conducted to identify the effects of the mandatory remote working regimes imposed by the COVID-19 Pandemic on task and contextual performance.

Results: Findings show that individual performance was assessed to have increased while internal processes remained at similar levels compared to pre-pandemic levels. Organizational culture, social contact, and identity, however, were reported to have considerably deteriorated in the view of the participants.

Discussion: The study shows that for a company that was very experienced with distributed working, the reduction of co-presence had important effects on performance and culture. Findings suggest that co-presence must be carefully managed in the future. This could become a new joint priority for workplace design, workplace management, and human capital management.
Combined chemical transformation and biological transformation of artemisinin: A facile approach to diverse artemisinin derivatives
Authors: Gao Xinna , Bai Yue , Sun Peng , Gao Huimin , Yang Lan , Zhang Dong , Zhao Yifan , Ma Yue
Published: January 2023

Introduction: Artemisinin (1) is a milestone compound in malaria treatment, and it exhibits a broad scope of bioactivities. Herein, sequential chemo-reduction and biotransformation of artemisinin were undertaken to obtain a series of artemisinin derivatives.

Methods: First, 10-deoxyartemisinin (2) and 9-ene-10-deoxyartemisinin (3) were synthesized after simple handling with boron trifluoride/diethyl ether and sodium borohydride. Then, biotransformation of 10-deoxyartemisinin was conducted with Cunninghamella echinulata CGMCC 3.4879 and Cunninghamella elegans CGMCC 3.4832, and the transformed products were separated and identified. The antimalarial activity of these products was tested in vitro against Plasmodium falciparum 3D7.

Results: Fifteen metabolites (4–18), including seven novel compounds, were isolated and identified after cultivation. Compounds 2, 3, 13, 15, 16, and 18 displayed moderate-to-good antimalarial activity, with a half-maximal inhibitory concentration ranging from 6 to 223 nM.

Discussion: This work explored the combination of chemical and biological transformation to develop a co-environmental, efficient, and cost-efficiency synthetic methodology and applied it to synthesize novel derivatives of artemisinin. The association of the two strategies will hopefully provide an abundant source for the development of novel drugs with bioactivities.