bluuebunny/crossref_metadata_2025 huggingface dataset:
Turismo médico: innovación y desafíos en la investigación global
Authors: Almeida Espinosa Alexander , López Mallama Oscar , Uribe Jiménez Marisol
Published: February 2025

El turismo médico es una industria en expansión que ha despertado un interés académico cada vez mayor. Este estudio bibliométrico, basado en 2477 documentos, emplea técnicas de análisis de rendimiento y mapas de redes para examinar el estado actual de la investigación en este campo. Su propósito es proporcionar una visión integral de producción científica, identificando tendencias, patrones de publicación y actores clave como países, revistas, y autores influyentes, así como las principales líneas temáticas y vacíos en la literatura. Los temas más estudiados incluyen los riesgos y complicaciones del turismo médico, sus impactos socioeconómicos, el turismo de fertilidad y los tratamientos con células madre, la gestión de destinos turísticos y las estrategias de marca en salud. Asimismo, se abordan cuestiones relacionadas con la satisfacción del paciente, la sostenibilidad de los modelos de negocio y el papel de las tecnologías emergentes en la prestación de servicios. El estudio identificó áreas que requieren mayor atención, como el impacto del turismo médico en los países de origen y destino, la calidad y seguridad de los servicios, las experiencias de los turistas médicos y las implicaciones éticas. Los hallazgos de esta investigación documental buscan establecer las bases para futuros estudios y políticas que maximicen los beneficios y mitiguen los riesgos del turismo médico.
Being a mother of a child with HIV-related Neurodevelopmental disorders in the Zimbabwean Context
Authors: Munambah Nyaradzai , Gretschel Pam , Sonday Amshuda
Published: February 2025

Background: There is a growing population of mothers caring for their biological children who are infected with Human Immunodeficiency Virus (HIV), in Zimbabwe. Many of these children present with HIV-related Neuro Developmental Delays (NDDs).  The occupation of being a mother is a complex and multifaceted role geared towards caring for and nurturing children.  The different ways in which mothers negotiate the unique circumstances linked to the occupation of being a mother to a child with diagnosis of HIV-related NDDs warrants exploration.Aim: The aim of the study was to describe the mother's experiences of engaging in daily occupations relating to caring for their with HIV-related NDDs.Methodology: A descriptive qualitative study using a hermeneutic phenomenological approach was used to uncover the mothers' lived experiences of caring for their child with HIV-related NDDs. Data generated from phenomenological interviews conducted with five mothers were analysed inductively using a simplified version of the StevickColaizzKeen method.Findings: Two major themes, namely 'Ndozvazviri' (Resilient Acceptance) and 'Rekindled hope for the future' emerged from the findings. These themes revealed that caring for a child with HIV-related NDDs is a difficult and demanding role. Despite this, mothers accepted and found meaning in this caring role. Their meaning was expressed through the opportunity to care for their own child and to observe their progress in occupational development and engagement. These interactions created positive experiences for the mothers and rekindled their hope for the future of their child.Discussion and recommendations: Despite the huge demands associated with being a mother of a child with HIV-related NDDs. mothers were committed to this role and were reluctant to entrust this role to others. The findings of this study encourage occupational therapists designing interventions for families, to carefully consider how the mothering role positively shapes the identities of mothers caring for children with HIV-related NDDs.
Key words: mothering, HIV-related NDDs, caregiver
Long-Term impact of rice cultivation on soil quality indicators in Northern Amazonia Savanna
Authors: Ferreira Melo Valdinar , Evald Ariane , Ribeiro Rocha Paulo Roberto , Pereira Uchôa Sandra Cátia , Bardales-Lozano Ricardo Manuel , Senwo Zachary , Adandonon Apollinaire
Published: February 2025

Changes in soil attributes following changes in management strategies in rice cultivation can alter soil quality, either positively or negatively. The aim of this study was to evaluate soil quality indicators, based on physical, chemical and microbiological soil attributes in Amazonian savanna under rice cultivation with different ages. The research was conducted in five areas under continuous rice cultivation during 1, 3, 8, 13, and 25 years, compared with local reference native vegetation. Soil samples were collected at 0-10 cm depth and evaluated for physical attributes such as texture and bulk density, chemical properties such as soil organic carbon, total nitrogen, exchangeable cations, available P, pH, CEC and C/N ratio; and microbiological attributes like microbial biomass carbon, soil microbial respiration, metabolic ratio and microbial coefficient. Acid phosphatase and urease activity were evaluated. With longer periods of time of rice cultivation, soil quality was enhanced with increasing soil fertility, increased soil organic carbon content and enzyme activity. The paddy soil indicators were sensitive to changes in rice cultivation and its duration. Acid phosphatase activity and available phosphorus increased with longer time of rice cultivation, indicating a possible conversion of inorganic into organic phosphorus forms, corroborated by increasing phosphatase activity. Microbiological (SMB-C, SBR, qMIC and qCO2) and biochemical (urease and acid phosphatase) indicators, as well as soil organic carbon and total nitrogen were highly sensitive to land use changes. Chemical and microbiological indicators are suitable for estimating paddy soil quality in lowland of Amazonian savanna.
Effect of Fuel Injection Pressure Variations on Engine Performance-Emission-Particulate Matter with Diesel-Iso-Butanol-Nanoparticle Fuels in Compression Ignition Engine
Authors:   M.Tech. Student, Advanced Internal Combustion Engine, JNTUA College of Engineering (Autonomous), Ananthapuramu, 515002, A.P., India, Ayyappan Kuppan , Srinivasan D R
Published: February 2025

Background/Objective: Growing environmental concerns and the depletion of petroleum supplies have generated a lot of interest in alternate fuels. Made from renewable resources, biodiesel is one of the many useful and advantageous fuel alternatives to fossil fuels. The use of nanoparticles as fuel additives for internal combustion engines is now possible because to recent developments in nanotechnology. Previous research indicated that these substances could improve engine performance. This could lead to an increase in particulate matter released with the exhaust, which would have a negative impact on the quality of the air. This study investigates engine performance, emission properties, and size distribution of unregulated particulate matter (PM) released with exhaust gases. Methods: In this work, iso-butanol is proposed to be blended with Diesel along with aluminum oxide as a nano-additive 100 mg/L using Mechanical Strring method for 1 hour. Engine testing is conducted at fuel injection pressures of 180, 210, and 240 bar. To examine the performance, emission characteristics and particulate matter, a 4-stroke, single cylinder, direct-injection, 5-horsepower (3.5 kW) research Diesel engine was selected having a mass flow sensor, burette method, a dynamometer computerised data gathering system, a variety of sensors were used in the experiment to gather, store, and evaluate data (Internal Combustion engine software). Findings: Results indicated that blend B20 gives better results compare to other blends (B10, B30 and B40). In comparison to pure diesel fuel, the diesel/biodiesel blend combination produced 10–15 % less PM1, PM2.5, the Maximum brake thermal efficiency of Diesel(31.46 %), 180 bar(28.56 %), 210 bar(29.45 %), 240 bar (30.14 %). The maximum brake specific fuel consumption of Diesel(0.28 kg/kw-hr), 180bar(0.32 kg/kw-hr), 210 bar(0.31 kg/kw-hr), 240 bar(0.30 kg/kw-hr). The maximum of CO Diesel(0.22 %/vol), 180 bar (0.18 %/vol), 210 bar(0.14 %/vol), 240 bar(0.12 %of vol) as comparative of above values the blend B20 and injection pressure of 240bar shows smiliar to Diesel. Novelty: This study compares diesel and treated bio-diesel at different parameters: fuel injection pressures, break thermal efficiency, mechanical efficiency, and CO, HC, opacity, and particle matter.

Keywords: Iso-butanol, Aluminum oxide, Fuel injection pressure, Engine performance, Emission characteristics
Immunohistochemistry (Brain organoids) v1
Authors: Adami Anita
Published: February 2025

This protocol describes how to prepare brain organoids slides and how to perform immunostainings to study the expression and localization of target proteins in this 3D model.
Extraction of RNA from soybean leaves using the trizol method. v1
Authors: de Paula Alves Pinto Ian , Gusmão da Silva de Oliveira Phedra
Published: February 2025

The RNA extraction protocol from soybean leaves using the Trizol method presented below is an adaptation of the traditional method, with adjustments to enhance efficiency and minimize contamination and nucleic acid degradation, ensuring an optimized execution.
Citizens’ Appeals in Russian Legislation: Traditions and Modern Challenges for its Improvement
Authors: Maslennikova S. V.
Published: February 2025

The paper examines the experience of legal regulation of citizens’ appeals in the Russian prerevolutionary and Soviet periods. There is a continuity in the regulation of the institution of citizens’ appeals. The paper analyzes modern legislation on appeals, taking into account the correlation between general and special regulation. The author concludes that the role of the Federal Law dated 2 May 2006 No. 59-FZ «On the Procedure for Considering Appeals of Citizens of the Russian Federation» as a law of general regulation is predetermined by the socio-political nature of the right to appeal as a constitutional right and the right of a universal national nature, the implementation of which accompanies any sphere of activity of the authorities in their relations with citizens. The modern development of communications in the State and society, the complication of interaction between subjects, the introduction of IT technologies are challenges that encourage improvement of the legal regulation of the institution of appeals. On the basis of historical and legal and formal and legal methods, the author concludes that the definition of key concepts in the field of consideration of citizens’ appeals in electronic form, restriction of departmental rule-making, clarification of the status of subjects authorized to consider citizens’ appeals should be regulated primarily by means of a relevant federal law. When regulating the institution of appeals, one should focus not on the concept of providing public services, but on the idea of the participation of citizens in the management of state affairs traditional for Russia. It is also proposed to establish provisions on the inadmissibility of burdening citizens with additional requirements when submitting appeals, to provide for a list of communication channels and features of consideration of appeals for certain categories of citizens.
INFLUENCE OF DIFFERENT TYPES OF ALLOSTERIC REGULATORS ON THE BASAL AND HORMONE-STIMULATED ACTIVITY OF THE THYROID-STIMULATED HORMONE RECEPTOR IN VITRO AND IN VIVO
Authors: Derkach Kira Viktorovna , Shpakova Elena Alexandrovna , Didenko Egor A. , Sorokoumov Viktor N. , Shpakov Alexander O.
Published: February 2025

Background: Antithyroid drugs used to treat autoimmune hyperthyroidism lead to thyroid hormone deficiency when used for a long time. In this regard, it is relevant to develop thyroid-stimulating hormone receptor (TSHR) regulators capable of inhibiting TSHR activation by agonists acting on the orthosteric site of the receptor (TSH, autoantibodies to TSHR) and stimulating its basal activity. This function can be performed by allosteric TSHR regulators with agonist activity and negative allosteric modulators (ago-NAM).Aim: A comparative study of the effects of TPY4, a thieno[2,3-d]-pyrimidine derivative, and peptide 612–627-Lys(Palm)Ala, a derivative of the third cytoplasmic loop of TSHR, on basal and TSH-stimulated adenylate cyclase (AC) activity in thyroid membranes and on basal and thyrotropin-releasing hormone (TRH)-stimulated thyroid hormone levels when administered to male rats.Materials and methods: The activity of AC in membranes isolated from the rat thyroid gland was measured by the radioisotope method using [α-32P]-ATP as a substrate. The ability of the drugs to affect the basal and TRH-stimulated levels of thyroid hormones was assessed by treating rats with the peptide 612–627-Lys(Palm)Ala (750 μg/kg) and TPY4 (15 mg/kg). The concentrations of free thyroxine (FT4), total triiodothyronine (TT3), and TSH in the blood of rats were determined by enzyme immunoassay.Results: In rat thyroid membranes, TPY4 and 612–627-Lys(Palm)Ala in micromolar concentrations increased the basal activity of AC and decreased its stimulation by TSH (10-9 M), and TPY4 was more effective as an inhibitor of the TSH effect, while the peptide stimulated AC to a greater extent. When administered to rats, both compounds, although to varying degrees, increased the production of FT4 and TT3, but at the same time prevented its increase upon activation of the thyroid axis by TRH (100 μg/rat). They did not have a significant effect on the TRH-stimulated level of TSH in the blood, and this indicates that their targets are TSHR localized in thyrocytes.Conclusions: Structurally distinct allosteric ligands of TSHR, the thieno[2,3-d]-pyrimidine derivative TPY4 and the peptide 612–627-Lys(Palm)Ala, were characterized by a similar spectrum of pharmacological activity, functioning as an ago-NAM for TSHR. Their ability to prevent hyperactivation of TSHR without causing a decrease in thyroid hormone levels could be used to develop drugs for the treatment of autoimmune hyperthyroidism.
Fast Probabilistic Seismic Hazard Analysis Through Adaptive Importance Sampling
Authors: Houng Soung Eil , Ceferino Luis
Published: February 2025

Probabilistic seismic hazard analysis (PSHA) traditionally relies on two computationally intensive approaches: (a) Riemann Sum and (b) conventional Monte Carlo (MC) integration. The former requires fine slices across magnitude, distance, and ground motion, and the latter demands extensive synthetic earthquake catalogs. Both approaches become notably resource-intensive for low-probability seismic hazards, for which achieving a coefficient of variation (COV) of 1% for a 10−4 annual hazard probability may require 108 MC samples. We introduce adaptive importance sampling (AIS) PSHA, a novel framework to approximate optimal importance sampling (IS) distributions and dramatically reduce the number of MC samples to estimate hazards. We evaluate the efficiency and accuracy of our proposed framework using Pacific Earthquake Engineering Research Center PSHA benchmarks that cover various seismic sources, including areal, vertical, and dipping faults, as well as combined types. Our approach computes seismic hazard up to 3.7×104 and 7.1×103 times faster than Riemann Sum and traditional MC methods, respectively, maintaining COVs below 1%. We also propose an enhanced approach with a “smart” AIS PSHA variant that leverages the sampling densities from similar ground-motion intensities. This variant outperforms even “smart” implementations of Riemann Sum with enhanced grid discretizations by a factor of up to 130. Moreover, we demonstrate theoretically that optimal IS distributions are equivalent to hazard disaggregation distributions. Empirically, we show the approximated optimal IS and the disaggregation distributions are closely alike, for example, with a Kolmogorov–Smirnov statistic between 0.017 and 0.113. This approach is broadly applicable, especially for PSHA cases requiring extensive logic trees and epistemic uncertainty.
Comparative evaluation of dimensional accuracy of irreversible hydrocolloid impression material using different types of tray
Authors: Torane Abhishek Appasaheb , Quereshi Ashraf , Gundavar Shyam , Deshpande Saee , Pande Neelam
Published: February 2025

Irreversible hydrocolloid impression materials are widely used in dentistry due to their low cost and ease of use. To ensure accurate models, it is essential to determine the optimal tray design and material. This article compares the dimensional accuracy of irreversible hydrocolloid impressions using four different types.

To evaluate the dimensional accuracy of irreversible hydrocolloid impression materials with four different impression tray types, and to identify the optimal tray design and material for producing precise dental models.

Dentulous maxillary model was taken for the study. The canines and first molars of the model were replaced with metal dies on either side. The molar dies were made with two cusp one buccal and palatal .The trays used in the study were Perforated Rimlock tray, perforated stock metal tray, perforated stock plastic tray, perforated custom tray (self-cure acrylic resin). All the above mentioned trays were modified to get the exact same orientation of the trays every time for making the impressions. Therefore two extra handles are attached laterally on each tray. A hole was made in each handle for the orientation of the tray on tray positioning device. To position the each tray on the model in same orientation was difficult so to overcome this problem a tray positioning device was designed.

The antero-posterior distances (A-B and C-D) and cross arch distances (B-C and D-A) in all the groups were compared and found that the dimensional changes in all groups were insignificant except the Perforated stock plastic tray i.e. groups III, which showed highly significant differences

The proper impression material and tray combination is crucial and very important to achieve desirable results in terms of dimensional accuracy and the quality of the impressions. Thus the results of the present study should be helpful to the dental practitioners in selection of the impression tray before making impressions with the irreversible hydrocolloid impression material.
Putting the Passenger First: What Works and What does not Work in Urban Mobility Reforms in Latin America and the Caribbean
Authors: Gómez-Lobo Andrés
Published: February 2025

The Latin American and Caribbean region offers a rich history of innovative policies and investments in urban mobility. We review some of these experiences with the aim of extracting lessons that can provide guidance to policymakers in the design and implementation of successful urban transport reforms. Special emphasis is placed on users' welfare and how different policies impinge on their interests and behavior. Many reforms have faced difficulties by not considering the consequences of policy initiatives on users' welfare, especially their impact on time costs. Another relevant theme discussed in this document is that modern high-quality transit systems are expensive and fare revenues will generally not be sufficient to fund an ambitious reform. If public funds are not available, it is advisable to reduce the scope and scale of reform. Fortunately, there are many low-cost options to improve urban mobility. Furthermore, some pricing policies can improve mobility while raising revenues at the same time; resources that can then be used to subsidize transit services. While the optimal policy package will depend on the specific circumstances of each city and the available funding, what cannot be overlooked is the interest of users and passengers. Policymakers must always place themselves in their shoes and think through how their intended intervention will affect their travel experience, time and financial cost.
Adsorbents Based on Rice Production Waste and Natural Aluminosilicate for Purification of Wastewater from Dissolved Organic Compounds
Authors: Alekhina M.B. , Fidchenko M.M. , Khokhlov E.V. , Petukhova G.A. , Dubinina L.A.
Published: February 2025

The synthesis of carbon-mineral adsorbents was carried out in order to purify water from organic compounds using rice husk (RH) and its pyrolysis product (PRH) Adsorbents with a microporous structure were obtained by steam-gas activation of the PRH. Based on natural montmorillonite clay and hydrophobizers (RH and PRH), samples with a mesoporous structure were obtained by pyrolysis of a molded mixture of clay and a hydrophobizer. For the synthesized adsorbents, the isotherms of adsorption of water vapor at 20 °C and the isotherms of adsorption of nonionic surfactant neonol AF 9-10 from aqueous solutions at 20 °C in the concentration range of 0–80 mg/l were determined. It is shown that these adsorbents had an adsorption capacity of neonol AF 9-10 slightly inferior to the best industrial activated carbons. It is concluded that carbon-mineral adsorbents synthesized using RH and PRH can be recommended for adsorption treatment of wastewater from dissolved organic substances.
Transforming Public Sector Performance; Innovative Approaches to Optimizing Functional Positions in Kepahiang's Bureaucratic Reform
Authors: Zulhakim Abdul Aziz , Yogopriyatno Jatmiko
Published: February 2025

This research examines the challenges of optimizing functional positions in Kepahiang Regency as part of a wider program of bureaucratic reform, with a particular focus on improving the performance of the public sector. The management of functional positions in Kepahiang Regency presents a few challenges, including the placement of civil servants who do not align with the initial formation, the lack of requisite technical training, and suboptimal performance evaluation. This study employed a systematic approach to mapping the 204 functional officials across 26 work units, identifying 37 categories of positions that exhibited variations in the specific expertise required. A SWOT analysis was employed to evaluate the strengths, weaknesses, opportunities, and threats inherent to the management of functional positions in Kepahiang Regency. The results demonstrated a discrepancy between employees educational backgrounds and the requirements of their positions, which negatively impacted work efficiency and effectiveness. Furthermore, this research proposes the development of a predictive model that is tailored to the socioeconomic and demographic characteristics of the region, intending to support performance improvement. It is anticipated that this model will be used as a reference in human resource development planning in the public sector, as well as in strategic decision making. The findings of this research contribute to the strengthening of functional position management and the improvement of the compensation system, as well as more sustainable career development, to encourage better public services in Kepahiang Regency.
Kaplice na zamku w Kamieńcu Podolskim
Authors: Bania Zbigniew
Published: February 2025

W tekstach poświęconych zamkowi w Kamieńcu Podolskim znajdujemy wzmianki o znajdującym się na jego dziedzińcu kościele św. Stanisława, jak również o cerkwi prawosławnej. Na podstawie inwentarzy zamku z XVI oraz z początku XVII wieku można ustalić fundatorów i hipotetyczny czas powstania obiektów. Cerkiew wzniesiono pod koniec XIV wieku z fundacji litewskich książąt Koriatowiczów, kościół powstał z funduszy Jana Potockiego na przełomie XVI i XVII wieku. Gdy Kamieniec znalazł się pod okupacją turecką, zapewne w tym czasie po 1672 roku rozebrano cerkiew, a kościół zamieniono na meczet. Zrujnowany, został rozebrany po odzyskaniu Kamieńca przez Polskę w 1699 roku.
Long-term course of disease in 71-year-old patient with diagnosis of small cell lung cancer – case report and literature review
Authors: Kalisz Piotr , Gałuszka Bartłomiej , Kostorz-Nosal Sabina , Zielińska-Leś Izabela , Jastrzębski Dariusz , Ziora Dariusz , Syguła Dorota , Skoczyński Szymon
Published: February 2025

Rak drobnokomórkowy płuca jest najbardziej agresywnym nowotworem wywodzącym się z płuc. Obecne opcje leczenia opierają się na leczeniu systemowym (chemioterapia, immunoterapia) i radioterapii. Jedynie w rzadkich przypadkach możliwe jest wdrożenie leczenia chirurgicznego. Pomimo wysokiej wrażliwości na chemioterapię i radioterapię tylko niewielki odsetek pacjentów osiąga długoterminowe przeżycie. W pracy przedstawiono przypadek pacjenta po czterech liniach chemioterapii i radioterapii, które umożliwiły 5-letnią kontrolę choroby, wraz z analizą dostępnych opcji terapeutycznych, ich skutków ubocznych, a także czynników wpływających na odpowiedź na leczenie.
Innovation in The Marketing Mix of Educational Services in Increasing Competitiveness
Authors: Sahri Sahri , Mutohar Prim Masrokan , Sujianto Agus Eko
Published: February 2025

This study aims to examine the innovation of the marketing mix of educational services in increasing competitiveness and customer value at SMP Ar Rahmat. This research uses a qualitative approach with a case study method. Data collection was conducted through in-depth interviews, observation, and documentation. The results showed that SMP Ar Rahmat has innovated the marketing mix in several aspects, such as product innovation, price, promotion, and place. The innovation is directed to provide added value for customers and increase student and parent satisfaction. This research provides advice for SMP Ar Rahmat in innovating the marketing mix, such as improving service quality, expanding the reach of promotions, offering more varied educational programs, providing financial assistance, and collaborating with educational institutions or companies. This research can provide input for decision makers in the world of education to innovate the marketing mix as an effort to increase competitiveness and customer value in schools.
Implementation of Project-Based Learning to Improve Student Competence at Vocational High School
Authors: Abdillah Lucky Rafli , Wiyono Bambang Budi , Sultoni Sultoni
Published: February 2025

Quality education is essential to create a generation that can compete on a global level. Vocational education, in particular, plays a role in preparing a ready-made workforce. Vocational education in Indonesia still faces challenges, one of which is the inadequate quality of graduates according to the industry. Innovation in learning methods is needed, and project-based learning (PJBL) is considered effective in improving student competence. This study aims to provide an empirical or picture that PJBL can be implemented well and can improve the quality of student competence in every vocational education institution, with a focus on SMK Muhammadiyah 7 Gondanglegi. The location selection is based on information that the institution has successfully implemented the industrial PPA program. This research uses qualitative methodology with case study technique combined with positivistic paradigm. Inductive data analysis was conducted through data reduction, data visualization, conclusion drawing, and verification.The results showed that PJBL at SMK Muhammadiyah 7 Gondanglegi was effective in improving students’ competencies and skills. The implementation of a curriculum that is aligned with industry through cooperation with PT Astra Daihatsu Motor ensures the relevance of education to industry needs. PJBL emphasizes productive education that includes improving hard skills and soft skills, and involves students in real projects that combine theory and practice.
Systematic Review and Mapping of Theses in the Management of Islamic Education Program Based on Ontological, Epistemological, and Axiological Studies
Authors: Yaqien Nurul , Hasanah Siti Ma'rifatul , Uyun Fitratul
Published: February 2025

This research aims to systematically review and map theses within the Islamic education management program at State Islamic University of Maulana Malik Ibrahim Malang focusing on study of ontological, epistemological and axiological conducted from 2015 to 2018. The study utilized a combination of Systematic Mapping (SM) and Systematic Literature Review (SLR) methodologies. The research categorizes the structural elements of published theses based on various criteria, including the trends, methodologies, specific emphasis on the integration Islamic principles into education management practices. The analysis revealed the following findings: The results highlight significant trends, revealing the predominant themes in theses research, a total of 263 theses were analyzed, covering 14 themes. Ontologically, this review and capture the Islamic principle shape the understanding of thesis themes. These themes were examined through the lens of educational management theory and Islamic principles, resulting in a scientific integration between Islamic theory and management of education. Epistemologically, knowledge in management of Islamic education is derived more from religious texts and traditions and contemporary education and management theories. As for research significant majority (93.4%) utilized qualitative research methods, with only 6.6% utilizing quantitative approaches. The research sites included schools, madrasas, Islamic boarding schools, universities, and government institutions. Axiologically, this study would focus on the values that underpin the practice of theses that have direct implications for the development of graduate profiles, including; the enhancement of management skills, deeper insights into educational challenges, curriculum innovation and improvement, the formulation of education policies, and the development of leadership competencies.
Comparison of Symptom Distress Ranking Between Oncology Nurses and Pediatric Patients Receiving Chemotherapy
Authors: Şimşek Enes , Semerci Remziye , Erkul Münevver , Önal Ayşe , Kaboglu Dilek Dogan , Unuvar Aysegul , Birhekimoğlu OCAKÇI Ayşe Ferda
Published: February 2025

Purpose:This study aimed to identify and compare the chemotherapy-induced symptoms perceived as distressing by pediatric oncology patients and nurses, utilizing both patient-reported outcomes and proxy report outcomes frameworks.Methods:This cross-sectional, descriptive study was conducted in three university hospitals in Türkiye between January 2023 and December 2023. A total of 122 pediatric oncology patients and 139 pediatric oncology nurses participated. The Children’s Memorial Symptom Assessment Scale was used to rank the perceived distress of symptoms.Results:Both pediatric oncology patients and nurses identified lack of energy, pain, nausea, feeling nervous, and feeling drowsy as the five most distressing symptoms. However, discrepancies were noted between the two groups: Pediatric oncology nurses reported higher distress rankings for symptoms such as nausea (p= .018), dry mouth (p= .027), cough (p= .030), mouth sores (p< .001), and difficulty swallowing (p= .003) compared with the patients. Conversely, pediatric oncology patients reported higher distress rankings for feeling nervous (p= .016), weight loss (p= .003), constipation (p= .014), and swelling of arms/legs (p< .001).Conclusions:The study revealed a general alignment in the ranking of distressing symptoms between pediatric oncology nurses and patients, with some notable differences.Practice Implications:Understanding the differences in symptom perception between patients and nurses is crucial to enhancing patient-centered care in pediatric oncology. Tailoring interventions to address the specific distress identified by patients and nurses can improve care outcomes and patient well-being.
Migration of foreign bodies through the urinary system (clinical cases)
Authors: Baulina O. A. , Baulin A. A. , Baulin V. A. , Aver'yanova L. A.
Published: February 2025

Introduction. Migration of implantable materials is a rare but significant complication of surgical interventions in urological practice. Objective: to present an analysis of two clinical cases of unusual migration of fixing Capron (nylon) structures in the urinary system. Materials and methods. Two clinical observations are described: a case of migration of a fixing Capron suture into the kidney parenchyma after nephropexy and a case of transurethral migration of a supporting loop after surgery for urinary incontinence. Diagnostics was carried out using clinical examination, ultrasound imaging, computed tomography, and endoscopic methods. Results. In the first case, the migration of the Capron suture into the kidney parenchyma was successfully resolved through laparoscopic removal of the structure and replacement with a polypropylene one. In the second case, spontaneous transurethral migration of the fixing loop occurred without the development of stricture and with preservation of the functional result of the operation. Conclusion. The presented observations demonstrate the possibility of gradual migration of Capron structures through the tissues of the urinary system without developing serious complications. These cases emphasize the importance of suture material selection in urological operations and the need for long-term patient monitoring.
Modern approaches to the diagnosis of endometrial hyperplasia
Authors: Damirov M. M. , Yurchenko O. B. , Titova G. P. , Borovkova N. V. , Ierusalimskiy A. P.
Published: February 2025

Introduction. In recent years, there has been an increase in the frequency of various nosological forms of endometrial hyperplasia, which is diagnosed in 38-72% of women of reproductive age. The information content of the applied instrumental diagnostic methods ranges from 47 to 89%. In the pathogenesis of endometrial hyperplasia, an important role is played by the imbalance of the processes of proliferation, differentiation and death of cells. The aim of the study. This review aims to study the information content of instrumental diagnostic methods in patients with different types of endometrial hyperplasia, as well as to analyze some indicators of apoptosis in the blood and endometrial tissue in patients with endometrial hyperplasia without atypia and in patients with atypical endometrial hyperplasia. Object and methods. A comprehensive clinical, instrumental and biochemical study was conducted on 36 patients of reproductive age (mean age 45.7±3.41 years) with different types of endometrial hyperplasia. All patients were examined using clinical, echographic, hysteroscopic and morpho-biochemical methods. The patients were divided into two groups. Group 1 included 25 (69.4%) patients with endometrial hyperplasia without atypia; Group 2 included 11 (30.6%) patients with atypical endometrial hyperplasia. A comparative analysis of the diagnostic methods used was conducted and compared with the morphological method. Results and its discussion. A study of some indicators of apoptosis in the blood and endometrial tissue in patients from the studied groups was performed. It was noted that patients with endometrial hyperplasia without atypia and atypical endometrial hyperplasia had a violation of the regulation of cellular homeostasis due to an imbalance of apoptosis factors and cell proliferation. Conclusion. A decrease in the concentration of factors initiating apoptosis is accompanied by a decrease in the induction of programmed endometrial cell death. Dysregulation of apoptosis leads to a decrease in the content and abolition of cyclic changes in the number of apoptotic cells in the endometrium.
Comparative Nutritional Analysis: Routine Dietary Intake vs. Recommended Guidelines – A Case Study of a 27-Year-Old Male Athlete in Khartoum, Sudan
Authors: Mohammed Somiya Gutbi Salim , Hussein Maida Taher Mohammed , Kulais Sara Mohamed Ali
Published: February 2025

This case report evaluates the nutritional status of a 27-year-old male basketball athlete who trains for approximately 3 hours once a week on the basketball court at Umst/Mecca Street in Khartoum state. Using the Mifflin-St Jeor Equation, his Basal Metabolic Rate (BMR) was calculated at 1,740 kcal/day, leading to a Total Daily Energy Expenditure (TDEE) of 4,618.95 kcal/day when accounting for physical activity. A 24-hour dietary recall revealed an energy intake of 2,714.7 kcal/day, resulting in a significant caloric deficit of around 1,904.25 kcal/day. Macronutrient analysis showed that his intake of carbohydrates (265 g), protein (188 g), and fats (100.3 g) fell short of optimal recommendations for an athlete of his profile. Specifically, carbohydrate intake was far below the recommended 500-700g, while protein was high but could be moderated for better recovery. Recommendations include substantially increasing carbohydrate intake to 500-600g, reducing protein to 128-160g to better align with recovery needs, and incorporating more healthy fats (120-130g) to enhance caloric intake. These adjustments are essential to improve performance, support recovery, and ensure the athlete’s long-term health and well-being. Regular dietary assessments will help adapt to the training demands effectively.
Awareness and Adherence to the Guideline-Directed Medical Therapy for Treatment of Diabetes Among Physicians in Aden, Yemen: A Nationwide Survey
Authors: Assiri Ammar , Basheer Safa , Waleed Amna , Alyumaini Aisha , Afef Ebrahim , Nasr Hamedah , Al-Qattibi Sultan , Alshamsani Rana , Al-Atar Ana'a , Khan Alaa , Muthanna Fares M.S.
Published: February 2025

This study examines the awareness and adherence of physicians in Aden, Yemen, to national diabetes management guidelines, focusing on the challenges affecting implementation. A cross-sectional survey was conducted in July 2023 with 115 physicians from various hospitals in Aden, Yemen. The survey explored physicians' familiarity with the guidelines, the frequency of their review, and perceived obstacles to adherence. The sample comprised 70 male (60.9%) and 45 female (39.1%) physicians, with most working in urban hospitals (73.9%). The majority (91.3%) were aged 60 or younger, and 56.5% were specialists, including endocrinologists and internal medicine physicians. The findings revealed that 68% of physicians were aware of the guidelines, with 93% adhering to them for most patients. A significant 67% felt the guidelines improved patient outcomes, and 75% were confident in implementing them. However, 77% of respondents faced barriers to full implementation, such as limited resources, patient non-compliance, and insufficient training. Despite high awareness, adherence was hindered by these challenges. The study underscores the need for better resource allocation, targeted educational initiatives, and ongoing professional development to enhance adherence to diabetes management guidelines and improve patient care outcomes in Yemen.
Vida Acadêmica: Tomadas de Posição Diante do Sofrimento
Authors: Coelho Júnior Achilles Gonçalves , Teixeira Tiago Alves
Published: February 2025

O aumento do acesso ao ensino superior criou contexto para problematização da experiência nesse espaço, destacando as dificuldades identificadas pelos estudantes a fim de que os modos de enfrentamento possam ser conhecidos e sistematizados. Este estudo teve como objetivo identificar e compreender os posicionamentos dos acadêmicos diante das dificuldades encontradas na vida acadêmica. Para tanto, foi usado o método fenomenológico de pesquisa empírica em Psicologia. Foram realizadas entrevistas semiestruturadas on-line, de orientação fenomenológica, das quais participaram 13 colaboradores, universitários, dos sexos masculino e feminino, com idades entre 19 e 43 anos, voluntariamente. Após transcritos, os depoimentos foram analisados a partir do método fenomenológico e do cruzamento intencional. Identificou-se seis unidades de sentido que apontam para posicionamentos de autoconfiança e descobrimento de si mesmo, com maior força do que então se imaginava, para enfrentar as adversidades que circunda o cursar o ensino superior, envolvendo a religiosidade, o sentido vivido no curso e a busca por ajuda como posicionamentos importantes nesse processo. Indicando, assim, a presença das potencialidades humanas em ação, os estudantes conseguiram se posicionar diante dos desafios, o que parece apontar para a presença de uma tendência humana de crescimento.
Estresse, Ansiedade e Depressão e Associação com Qualidade de Vida, Sexo e Uso de Psicofármacos em Estudantes Universitários: Estudo Transversal
Authors: Alves Bruna de Oliveira , Chaves Érika de Cássia Lopes , Paiva Eliza Mara das Chagas , Chaves Rafael Lopes , Lourenço Bárbara Guimarães , Oliveira Marina das Dores Nogueira de , Ribeiro Guilherme Antônio Gonçalves , Moura Caroline de Castro
Published: February 2025

Introdução: A saúde mental de estudantes universitários é um problema de saúde pública em âmbito mundial e pode estar associada a pior qualidade de vida. O objetivo do presente estudo consiste em avaliar a associação entre as variáveis estresse, ansiedade e depressão e qualidade de vida, sexo e uso de psicofármacos em estudantes universitários. Métodos: Estudo transversal, realizado de forma on-line, com 131 estudantes universitários, entre setembro e dezembro de 2022. A avaliação dos níveis de estresse, ansiedade e depressão foi realizada utilizando a Depression, Anxiety and Stress Scale (DASS-21), e a qualidade de vida foi avaliada por meio do World Health Organization Quality of Life-Bref (WHOQOL-Bref). Análises bivariadas foram realizadas para determinar a existência de associação entre as variáveis, a 5% de significância. Resultados: foram identificados altos níveis de estresse (89,30%), ansiedade (83,10%) e depressão (80,90%) entre os estudantes. Essas variáveis apresentaram associação negativa e estatisticamente significativa com a qualidade de vida. Observou-se associação estatisticamente significativa entre o uso de psicofármacos e as variáveis depressão, ansiedade e estresse. No entanto, não foi identificada associação significativa em relação ao sexo. Discussões e conclusões: Sintomas de estresse, ansiedade e depressão predispõem os estudantes universitários a menor qualidade de vida e estão associados ao uso de psicofármacos. O rastreamento e as intervenções psicológicas sobre esses sintomas podem contribuir para melhorar a percepção de qualidade de vida nesta população.
Pertanggungjawaban Pidana bagi Pembuat Drug Design dalam Perspektif Hukum Narkotika
Authors: Aulia Rahma Sari
Published: February 2025

The proliferation of technology has fueled the rise of drug abuse, giving rise to new modus operandi such as "Drug Design," where novel chemical compounds are synthesized to mimic the effects of illicit drugs without falling under existing drug laws. These "designer drugs," like PCC Pills," have caused severe mental health issues, fatalities, and pose a significant challenge to law enforcement due to their rapid molecular modifications. To address this emerging legal issue, this paper employs a normative legal research methodology to analyze the associated legal implications. Drug Design, stemming from the illicit practices of clandestine chemists, complicates law enforcement efforts due to the difficulty in classifying these novel substances. Collaboration between law enforcement agencies and chemists is crucial to determine appropriate legal sanctions. Despite regulatory efforts, the challenges of regulating and enforcing against Drug Design remain substantial, necessitating a cautious approach to both drug law enforcement and the regulation of emerging substances.
Protecting Intellectually Disabled Child Victims Of Sexual Violence In Court Proceedings
Authors: Nadhine Fakhira Putri Ravanti  , Sarah Yessie Hana Monica
Published: February 2025

Intellectually disabled individuals have long faced social exclusion, making them vulnerable to violence which was left unreported. Childrens with intellectual disabilities are twice as likely to have a higher risk of exploitation. The situation raises alarms on the need to accommodate their special needs in ensuring equal treatments in court proceedings. This paper examines the challenges faced by the victims in the justice system using normative research methods to analyze legal cases by reviewing and analyzing various aspects of written laws and doctrines to resolve the continuous violation. The results provide that when the cases did make their way to the court proceedings, just 9% of the victims were accompanied by a translator, whilst 18% did not get any assistance, and the 82% rest of the victims did not have any experts as their representation. When the cases were reported and reached the court, they were often treated with discrimination. Tackling that problem the current regulation precisely Law Number 8 of 2016 on Persons with Disabilities need to better ensure the protection of intellectually disabled children meanwhile the court needs to provide assistance such as interpreters and health care workers to assist the victims. The urgency of this research is to promote equality and ensure the intellectually disabled children as victims will receive their well-deserved justice.
Lung Aging and Lung Function Assessment in Elderly
Authors: Wesnawa Made Agustya Darma Putra , Subagiarta I Made , Nathania Evelyn
Published: February 2025

The lung is one of the organs that experiences the most frequent decline in function among the elderly. Reduced lung function associated with aging is a physiological condition. The lungs transform both their cellular composition and their functional capabilities. The lungs of an aging population may show structural changes to the respiratory muscles, chest wall, lung parenchyma, and upper and lower respiratory tracts. The elderly are more susceptible to reduced lung perfusion, respiratory mechanics, infection, and weaker respiratory muscles because of aging. The body plethysmograph, oscillometer, spirometry, and carbon monoxide (CO) diffusing lung capacity are techniques used to assess lung function in the elderly. For elderly people, lung function testing might be challenging due to frailty and cognitive decline. Consequently, choosing the best lung function test method for the elderly and offering an accurate and suitable interpretation of the test findings are crucial. Early detection of changes in lung function and accurate assessment of lung function can help identify lung function abnormalities in the elderly and give the appropriate treatment and intervention. This review focused on lung aging, the potential benefits and drawbacks of different lung function tests in the elderly, and the proper way to interpret specific lung function tests.
Sequence-based imitation learning for surgical robot operations
Authors: Furnari Gabriele , Secchi Cristian , Ferraguti Federica
Published: February 2025

Aim

This paper aims to advance autonomous surgical operations through imitation learning from video demonstrations.

Methods

To address this objective, we propose two main contributions: (1) We introduce a new dataset of virtual kidney tumor environments to train our model on. The dataset is composed of video demonstrations of tumor removal from the kidney, executed in a virtual environment, and kinematic data of the robot tools; (2) We employed an imitation learning architecture composed of vision transformers (ViT) to handle the frames extracted from the videos and of a long short-term memory (LSTM) structure to process surgical motion sequences with a sliding window mechanism. This model processes video frames and prior poses to predict the poses for both robotic arms. A self-generating sequence approach was implemented, where each predicted pose served as the latest element in the sequence, subsequently used as input for the next prediction together with the current frame of the video. The choice of architecture and methodology was guided by the need to effectively model the sequential nature of surgical operations.

Results

The model achieved promising results, exhibiting an average position error of 0.5 cm. The model was able to execute correctly 70% of the test tasks. This highlights the sequence-based approach’s efficacy in capturing and predicting surgical trajectories.

Conclusion

Our study supports imitation learning’s viability for acquiring task execution policies in surgical robotics. The sequence-based model, combining ViT and LSTM architectures, successfully handles surgical trajectories.