bluuebunny/crossref_metadata_2025 huggingface dataset:
Impacts of temporal resolution of atmospheric de-aliasing products on gravity field estimation
Authors: Bai Yinglun , Chen Qiujie , Shen Yunzhong , Xiao Yun , Zhang Xingfu
Published: March 2024

Despite the increasing accuracies of GRACE (Gravity Recovery and Climate Experiment)/GRACE-FO (GRACE Follow-On) gravity field models through worldwide endeavours, the temporal aliasing effect caused by the imperfect background models used in gravity field modelling is still a crucial factor that degrades the quality of gravity field solutions. Since the important role of temporal resolution of atmospheric de-aliasing models, this paper specifically investigates the influence of temporal resolution on gravity field modelling from the perspectives of frequency, spectral and spatial domains. To this end, we introduced the gravitational acceleration and geoid height derived from the static gravity field GOCO06s in the inner integral. The introduction of the static gravity field has a comparable impact on LRI (Laser Ranging Interferometers) range-rate residuals as the accuracy of the LRI range-rate data, despite its magnitude of being less than 0.1 mm in the spatial domain. This finding also highlights the significance of error level in existing de-aliasing products as a crucial factor that restricts the current accuracy of gravity field solutions. Further analyses show that increasing the temporal resolution from 3 to 1 hr has an insignificant impact on the gravity solutions in both the frequency and spectral domains, which is also smaller than that caused by using different atmospheric data sets. However, in the spatial domain, LRI range-rate residuals can be effectively mitigated in certain regions of the Southern Hemisphere at mid- and high-latitudes by increasing the temporal resolution. Particularly, the discrepancies of mass change estimates brought about by enhancing temporal resolution have distinct characteristics, especially in the Congo River and the Amazon River Basins. The mass changes in terms of equivalent water height derived by using P4M6 filtering show that the maximum root mean square value of spatial differences caused by improving the temporal resolution of the atmospheric de-aliasing models can reach ∼13.4 mm in the subregion of the Congo River Basin. However, using different atmospheric data sets can lead to a maximum difference of ∼16.5 mm. For the Amazon River Basin, the corresponding maximum discrepancy is ∼18.1 mm, and that caused by improving temporal resolution is ∼9.4 mm. We further divide the Congo River Basin into several subregions using a lat-lon regular grid with a spatial resolution of 3°. The subsequent time-series results of mass changes reveal that the maximum contribution of temporal resolution and changes in the atmospheric data sets can reach 11.09 and 21.24 per cent, respectively. This suggests that it is necessary to consider the temporal resolution of de-aliasing products when studying mass changes at a regional scale.
Pyrus betulaefolia ERF3 interacts with HsfC1a to coordinately regulate aquaporin PIP1;4 and NCED4 for drought tolerance
Authors: Zhang Feng , Pan Zhijian , Han Chenyang , Dong Huizhen , Lin Likun , Qiao Qinghai , Zhao Keke , Wu Juyou , Tao Shutian , Zhang Shaoling , Huang Xiaosan
Published: March 2024

Environmental disasters like drought reduce agricultural output and plant growth. Redox management significantly affects plant stress responses. An earlier study found that PbPIP1;4 transports H2O2 and promotes H2O2 downstream cascade signaling to restore redox equilibrium. However, this regulatory mechanism requires additional investigation. In this search, the AP2 domain-containing transcription factor was isolated by screening Y1H from the wild pear (Pyrus betulaefolia) cDNA library, named PbERF3. The overexpression of PbERF3 in pear callus and Arabidopsis enhanced plant resistance to drought and re-established redox balance. The transcripts of the NCEDs gene were upregulated under drought stress. The drought stress-related abscisic acid (ABA) signaling pathway modulates PbERF3. PbERF3 silencing lowered drought tolerance. Furthermore, yeast 2-hybrid, luciferase, bimolecular fluorescence complementation, and co-immunoprecipitation assays verified that PbERF3 physically interacted with PbHsfC1a. The PbERF3-PbHsfC1a heterodimer coordinately bound to PbPIP1;4 and PbNCED4 promoter, therefore activating both the H2O2 and the ABA signaling pathway. This work revealed a novel PbERF3-PbHsfC1a-PbNCED4-PbPIP1;4 regulatory module, in which PbERF3 interacts with PbHsfC1a to trigger the expression of target genes. This module establishes an interaction between the H2O2 signaling component PbPIP1;4 and the ABA pathways component PbNCED4, enabling a response to drought.
Residual life prediction of lithium battery based on hybrid model of WOA–VMD and attention mechanism
Authors: Tao Qiong , Lv Jie , Wu Jia
Published: March 2024

In order to improve the long-term reliability of lithium battery and ensure the safe operation of the system, a forecasting method combining whale optimization algorithm (WOA), variational mode decomposition (VMD) and the Gated Recurrent Unit model with Attention mechanism (GRU-Attention) was proposed. WOA–VMD was used to decompose the battery capacity data into the intrinsic mode component and residual component, which were, respectively, predicted by GRU-Attention, and finally effectively integrated to obtain accurate capacity prediction results. Through the experiments of the Li-ion battery data set of the Advanced Life Cycle Engineering Center of the University of Maryland, the proposed Li-ion battery combination prediction model has high prediction accuracy and stability. This method is a novel combination of advanced technologies and algorithms, and its effectiveness in improving the long-term reliability of lithium batteries has been verified by experiments. This research is of great significance for promoting the development and application of lithium battery technology.
Command filter-based adaptive neural two-bit-triggered containment control for saturated nonlinear multi-agent systems
Authors: Wu Yuhang , Niu Ben , Xu Ning , Zhao Xudong , Ahmad Adil M
Published: March 2024

This paper considers the adaptive two-bit-triggered containment control problem for nonlinear multi-agent systems in the presence of input saturation. Since input saturation occurs frequently in practical systems, which can affect the stability of the multi-agent systems under consideration, an auxiliary design system is introduced to address this issue. Meanwhile, considering limited transmission resources in practical systems, this paper mainly focuses on the triggering condition and the control signal transmission bits, presenting a two-bit-triggered control approach to optimize the utilization of transmission resources. Furthermore, a command filter is introduced into the design process to solve the problem of complexity explosion. The proposed method ensures that all signals of the closed-loop system are bounded and the output signals of all followers converge to a convex hull spanned by the outputs of the leaders. Finally, two simulation examples are provided to verify the validity of the presented control scheme.
Stability and co-existence state traveling wave solution for a general N-dimensional diffusive delayed Lotka-Volterra equation in a cylinder
Authors: Tian Yanling , Shen Shuyuan , Yang Jinji
Published: March 2024

A general $N$-dimensional non-monotone delayed diffusive Lotka–Volterra model is considered in our paper. First, we obtain the global stability of the model subject to Neumann boundary condition by using a small delay result for delayed systems. Second, the limits at $+\infty $ of bounded travelling wave solutions are confirmed by virtue of such global stability. Therefore, the existence of co-existence state travelling wave solutions is established. Finally, an example is given to illustrate the biological significance of the assumptions in the current paper.
No Safe Haven: Operation Condor and Transnational Repression in South America
Authors: Lessa Francesca , Balardini Lorena
Published: March 2024

Transnational repression, i.e., the deliberate targeting of refugees and dissidents by states across borders, is a relatively understudied subject in international relations. This article analyzes why states act together to persecute political opponents abroad and explains variations in such practices. It proposes a theory of cooperation in transnational repression and uses the case study of Operation Condor in the 1970s to test it. Through Operation Condor, South American authoritarian states willingly forewent key aspects of their sovereignty to establish a sophisticated system of cooperation to target dissidents abroad. This scheme was a critical extension of these countries’ domestic-level policies of repression against political opposition and enabled them to target politically active refugees wherever they were located. Exiles were perceived as constituting an existential threat to these autocracies’ survival, given their ability to potentially undermine both their internal and external regime security, which therefore warranted their elimination. We draw on an interdisciplinary methodology, which combines archival research, interviews, trial observation, and the analysis of legal verdicts, alongside conclusions derived from our novel dataset, the Database on South America's Transnational Human Rights Violations (1969–1981).
Maximizing Mentorship Throughout Your Breast Imaging Career
Authors: Mullen Lisa A , Weinfurtner R Jared , Borovicka Kathy M , Hoyt Tamarya L , Letter Haley P , O’Brien Sophia R , Swamy Nayanatara , Vicenti Kerri L , Woodard Stefanie A , Xavier Brian A , Gundry Kathleen R , Merkulov Alex , Margolies Laurie R , Slanetz Priscilla J
Published: March 2024

Unlike many other subspecialties in radiology, breast radiologists practice in a patient-facing and interdisciplinary environment where team building, communication, and leadership skills are critical. Although breast radiologists can improve these skills over time, strong mentorship can accelerate this process, leading to a more successful and satisfying career. In addition to providing advice, insight, feedback, and encouragement to mentees, mentors help advance the field of breast radiology by contributing to the development of the next generation of leaders. During the mentorship process, mentors continue to hone their listening, problem-solving, and networking skills, which in turn creates a more supportive and nurturing work environment for the entire breast care team. This article reviews important mentorship skills that are essential for all breast radiologists. Although some of the principles apply to all mentoring relationships, ensuring that every breast radiologist has the skills to be both an effective mentor and mentee is key to the future of the profession.
Make Hay While the Sun Shines: an Empirical Study of Maximum Price, Regret, and Trading Decisions
Authors: Brettschneider Julia , Burro Giovanni , Henderson Vicky
Published: March 2024

Time-constant trading thresholds are optimal for a large class of preferences and asset price dynamics, including, Expected Utility and the S-shaped reference-dependent utility of Prospect Theory. Such thresholds imply selling stocks at the maximum price since purchase. We use a large discount brokerage dataset containing US households’ trading records between 1991 and 1996 to document that in 31.6% of cases the stocks sold for a gain are sold on the day when the maximum since purchase occurs. However, not all stocks are sold at a maximum since purchase and the propensity to sell changes depending on how far in time and price the stock is with respect to this past maximum. We find that the propensity to sell initially increases as the price is closer to the past maximum but it then decreases when the price gets in the closest region to the past maximum, leading to an inverse U-shape; and that investors are less likely to sell a gain, the further away in time the maximum price occurred. Studying the joint effect of price and time distance, we find that the propensity to sell is highest at low time distance and high price distance from the maximum since purchase. We relate these findings to regret, belief updating, and attention.
Characterization and correlation of the probing behaviors of Macrosteles quadrilineatus (Hemiptera: Cicadellidae) with electropenetrography (EPG) waveforms
Authors: Romero Berenice , Rojek Joanna , Wist Tyler , Prager Sean M
Published: March 2024

Aster leafhopper (Hemiptera: Cicadellidae: Macrosteles quadrilineatus Forbes) is a polyphagous insect species that migrates into the upper Midwest of the United States and the Western Canadian Prairies. Populations of this insect are associated with the transmission of a plant pathogen (Candidatus Phytoplasma asteris, 16SrI) to several annual crops and perennial plant species. Previous studies suggest that aster leafhoppers can sometimes prefer less suitable hosts for their development and survival, yet it is unclear if this lower performance on certain plant species is associated with reduced or impaired probing behaviors due to characteristics of the plants. To characterize the probing behaviors of aster leafhoppers, direct current electropenetrography recordings of male and female adults on barley (Polaes: Poaceae: Hordeum vulgare L.) were combined with plant histology, allowing the identification of nine waveforms and their proposed biological meanings. For each waveform, the number of waveform events per insect (NWEI), the waveform duration per insect (WDI), the waveform duration per event per insect (WDEI), and the percentage of recording time were calculated and statistically compared between sexes. Male and female aster leafhoppers exhibited similar behavioral responses for most of these variables, except for the NWEI for waveforms associated with nonprobing activities and the pathway phase. In these cases, male aster leafhoppers exhibited a higher number of events than females. Comparison of the proposed waveforms in this study with previous work on other hemipteran species provided additional support to the interpretation of the biological activities associated with each waveform.
Novel B-cell subsets as potential biomarkers in idiopathic inflammatory myopathies: insights into disease pathogenesis and disease activity
Authors: Reyes-Huerta Raúl F , Mandujano-López Vladimir , Velásquez-Ortiz Ma Guadalupe , Alcalá-Carmona Beatriz , Ostos-Prado María J , Reyna-Juárez Yatzil , Meza-Sánchez David E , Juárez-Vega Guillermo , Mejía-Domínguez Nancy R , Torres-Ruiz Jiram , Gómez-Martín Diana , Maravillas-Montero José L
Published: March 2024

Idiopathic inflammatory myopathies are a heterogeneous group of rare autoimmune disorders characterized by progressive muscle weakness and the histopathologic findings of inflammatory infiltrates in muscle tissue. Although their pathogenesis remains indefinite, the association of autoantibodies with clinical manifestations and the evidence of high effectiveness of depleting therapies suggest that B cells could be implicated. Therefore, we explored the landscape of peripheral B cells in this disease by multiparametric flow cytometry, finding significant numerical decreases in memory and double-negative subsets, as well as an expansion of the naive compartment relative to healthy controls, that contribute to defining disease-associated B-cell subset signatures and correlating with different clinical features of patients. Additionally, we determined the potential value of these subsets as diagnostic biomarkers, thus positioning B cells as neglected key elements possibly participating in idiopathic inflammatory myopathy onset or development.
Postmortem neuropathology in early Huntington disease
Authors: Hedreen John C , Berretta Sabina , White III Charles L
Published: March 2024

Two aspects of the neuropathology of early Huntington disease (HD) are examined. Neurons of the neostriatum are counted to determine relative loss in striosomes versus matrix at early stages, including for the first time in preclinical cases. An immunohistochemical procedure is described that tentatively distinguishes early HD from HD mimic disorders in postmortem brains. Counts of striatal projection neurons (SPNs) in striosomes defined by calbindin immunohistochemistry versus counts in the surrounding matrix are reported for 8 Vonsattel grade 0 (including 5 premanifest), 8 grade 1, 2 grade 2 HD, and for 8 control postmortem brains. Mean counts of striosome and matrix SPNs were significantly lower in premanifest grade 0 versus controls, with striosome counts significantly lower than matrix. In 8 grade 1 and 2 grade 2 brains, no striosomes with higher SPN counts than in the surrounding matrix were observed. Comparing dorsal versus ventral neostriatum, SPNs in dorsal striosomes and matrix declined more than ventral, making clear the importance of the dorsoventral site of tissue selection for research studies. A characteristic pattern of expanded polyglutamine-immunopositive inclusions was seen in all HD cases. Inclusions were always present in some SPNs and some pontine nucleus neurons and were absent in Purkinje cells, which showed no obvious cell loss.
An improved method for edge detection based on neighbor distance for processing hemispheric photography
Authors: Liu Yasi , Fan Dayong , Sun Han , Wang Xiangping
Published: March 2024

Hemisphere photos are now widely applied to provide information about solar radiation dynamics, canopy structure and their contribution to biophysical processes, plant productivity and ecosystem properties. The present study aims to improve the original ‘edge detection’ method for binary classification between sky and canopy, which works not well for closed canopies. We supposed such inaccuracy probably is due to the influence of sky pixels on their neighbor canopy pixels. Here, we introduced a new term ‘neighbor distance’, defined as the distance between pixels participated in the calculation of contrast at the edges between classified canopy and sky, into the ‘edge detection’ method. We showed that choosing a suitable neighbor distance for a photo with a specific gap fraction can significantly improve the accuracy of the original ‘edge detection’ method. We developed an ND-IS (Neighbor Distance-Iteration Selection) method that can automatically determine the threshold values of hemisphere photos with high accuracy and reproductivity. It combines the modified ‘edge detection’ method and an iterative selection method, with the aid of an empirical power function for the relationship between neighbor distance and manually verified gap fraction. This procedure worked well throughout a broad range of gap fractions (0.019–0.945) with different canopy compositions and structures, in five forest biomes along a broad gradient of latitude and longitude across Eastern China. Our results highlight the necessity of integrating neighbor distance into the original ‘edge detection’ algorithm. The advantages and limitations of the method, and the application of the method in the field were also discussed.
Child routines moderate a brief behavioral intervention to enhance sleep in school-aged children
Authors: Gebre Azeb , Hawley Nicola , Carskadon Mary A , Raynor Hollie , Jelalian Elissa , Owens Judith , Wing Rena R , Hart Chantelle N
Published: March 2024

Objective

To examine whether child routines (the consistency or variation in children’s daily routines, household responsibilities, discipline routines, and homework routines) moderated the effectiveness of a brief behavioral intervention to enhance sleep in school-aged children.

Methods

Secondary analysis was conducted with a subset of 66 families with short sleeping (≤9.5 hr/day) children, 8–11 years old (female = 68%; mean age = 9.76, SD = 1.02) who completed the Child Routines Inventory at baseline and were then randomized to receive a behavioral sleep intervention (n = 32) or to control (n = 34). Sleep period was objectively measured using wrist actigraphy at baseline and 2 months post-randomization. Moderation analysis was performed using ordinary least squares regression using the PROCESS macro for SPSS.

Results

Controlling for sleep period at baseline, treatment condition was significantly related to the sleep period at 2 months post-randomization, with the intervention group achieving a longer sleep period compared to the usual sleep period group (control) (b = 46.30, p < .01). Intervention response was moderated by child routines (b = 1.43, p < .05). Specifically, the intervention produced the greatest change in sleep period for children who engaged in greater routine behaviors at baseline than those who engaged in fewer routine behaviors.

Conclusions

Families that engage in routine behaviors may be better equipped to adopt the behavioral modifications required to get a good night’s sleep. The findings highlight the importance of working with families to establish routine behaviors to improve responses to behavioral sleep interventions.
FoxO1 as the critical target of puerarin to inhibit osteoclastogenesis and bone resorption
Authors: Feng Yanling , Tang Xulei
Published: March 2024

Background

Elevated reactive oxygen species levels promote excessive osteoclastogenesis and bone resorption. Puerarin, a natural antioxidant, can prevent bone loss through its antioxidant effects; however, the underlying molecular mechanism remains unclear. This study aimed to explore the effects of puerarin on osteoclast differentiation and bone resorption by regulating the PI3K/AKT/FoxO1 signaling pathway.

Materials and methods

An ovariectomized (OVX) rat model of osteoporosis and H2O2-induced oxidative cell model of RAW 264.7 cells were established. The following indices were measured including bone μ-CT scanning and the protein expression levels of FoxO1, p-FoxO1, and catalase were detected using western blotting.

Results

Puerarin strongly alleviated oxidative stress-induced bone loss in OVX rats in vivo owing to its antioxidant effects. Puerarin improved the oxidative stress status of cells and inhibited osteoclast formation in vitro. Moreover, the protein expression of FoxO1 and its downstream target, catalase, was upregulated by puerarin.

Conclusions

Puerarin improved the OPG/RANKL ratio, upregulated the protein expression and transcriptional activity of FoxO1, and suppressed the differentiation of RAW264.7 cells into osteoclasts. FoxO1 is a pivotal target of puerarin to confer anti-osteoporosis effects.
Minimax detection boundary and sharp optimal test for Gaussian graphical models
Authors: Qiu Yumou , Guo Bin
Published: March 2024

In this article, we derive the minimax detection boundary for testing a sub-block of variables in a precision matrix under the Gaussian distribution. Compared to the results on the minimum rate of signals for testing precision matrices in literature, our result gives the exact minimum signal strength in a precision matrix that can be detected. We propose a thresholding test that is able to achieve the minimax detection boundary under certain cases by adaptively choosing the threshold level. The asymptotic distribution of the thresholding statistic for precision matrices is derived. Power analysis is conducted to show the proposed test is powerful against sparse and weak signals, which cannot be detected by the existing Lmax and L2 tests. Simulation studies show the proposed test has an accurate size around the nominal level and is more powerful than the existing tests for detecting sparse and weak signals in precision matrices. Real data analysis on brain imaging data is carried out to illustrate the utility of the proposed test in practice, which reveals functional connectivity between brain regions for Alzheimer’s disease patients and normal healthy people.
Glans penis volume is associated with lifelong premature ejaculation
Authors: Ates Erhan , Gok Mustafa , Kazici Hakan Gorkem , Kol Arif , Sahin Tuna , Erol Haluk
Published: March 2024

Background

Although premature ejaculation (PE) is the most common male sexual dysfunction, the underlying mechanisms are not fully understood.

Aim

The study sought to evaluate the possible associations among glans penis volume and tissue stiffness measured using penile ultrasonography and penile shear wave elastography (SWE) with PE.

Methods

Men 18 to 65 years of age with normal International Index of Erectile Function scores (>25) and who were diagnosed with PE between June 2021 and June 2022 were enrolled. The Premature Ejaculation Diagnostic Tool score and intravaginal ejaculation latency times were recorded. Healthy volunteers constituted the control group. The study group was divided into lifelong PE (LLPE) and acquired PE (AqPE) subgroups. In all groups, the glans penis volume was measured via penile ultrasonography and tissue stiffness of the glans penis, penile frenulum, postcircumcision mucosal cuff, and penile shaft were measured via SWE. The findings of the groups were compared using appropriate statistical methods.

Outcomes

The outcomes included ultrasonographic and elastographic measurements of the glans penis.

Results

Data on 140 men, including 70 PE patients and 70 healthy volunteers, were evaluated. Of the patients, 20 had LLPE and 50 had AqPE. The median glans penis volume was significantly greater in the LLPE group (14.1 [range, 6.6-19] mm3) compared with the AqPE group (11.7 [range, 5.1-27] mm3) and control group (11.4 [range, 6.1-32] mm3) (P = .03). According to the Youden index, the best cutoff value for glans penis volume in LLPE compared with non-LLPE (AqPE + control) was 12.65 mm3 (area under the curve, 0.684; 95% confidence interval, 0.556-0.812; P = .009). The risk of having LLPE in those with a glans penis volume ≥12.65 mm3 was 3.326 (95% confidence interval, 1.234-8.965) times higher than the non-LLPE group (P = .014). There were no significant differences between the groups in the SWE evaluation of glans penis, penile frenulum, mucosal cuff, and penile shaft tissue stiffness.

Clinical Implications

The high incidence of PE in those with high glans penis volume may make glans penis volume a predictor for the development of LLPE.

Strengths and Limitations

This was the first study to show that PE is more common in individuals with a high glans penis volume. It was also the first to perform a penile elastographic evaluation in patients with PE. The most important limitation was that we did not evaluate glans penile nerve function with a test, but rather we made an indirect inference about the density of free nerve endings based on increased glans penile volume.

Conclusion

Glans penis volume was a significant predictor for LLPE. However, there are no associations between PE and the glans penis, postcircumcision mucosal cuff, penile frenulum, or penile shaft tissue stiffness and development.
Amplified PTSD Symptoms From Self-Attributed Moral Transgressions Are Linked to Internalized Moral Identity During Military Deployment
Authors: Sowden Walter J , Jones Rachell L
Published: March 2024

Introduction

Military personnel frequently experience stressful, morally challenging situations that can lead to posttraumatic stress disorder (PTSD). The relationships between moral identity, transgressive acts, and symptoms related to posttraumatic stress disorder (i.e., posttraumatic stress symptoms; PTSS) among U.S. Army Soldiers were assessed.

Materials and Methods

A convenience cohort of 1,547 soldiers completed a survey assessing moral identity and PTSS before deployment. A subset of 505 soldiers completed another survey assessing transgressive acts and PTSS during deployment. Exploratory and confirmatory factor analyses were conducted to determine the underlying factor structure of the measures of moral identity and transgressive acts. Generalized linear modeling, robustness checks, and sensitivity analysis were used to evaluate the predictive relationships.

Results

Moral identity did not directly predict PTSS during deployment. However, self-attributed and betrayal-based transgressive acts were significant predictors. Specifically, self-attributed transgressive acts and PTSS were moderated by internalized moral identity; individuals with a higher internalized moral identity experienced more severe PTSS following self-attributed transgressive acts. These findings were consistent across various model checks, including covariate adjustments, data imputation, and the application of a data quality filter.

Conclusions

The study highlights the significant role of self-attributed moral transgressions during deployment in the development of PTSS among military service members—especially in those with a strong internalized moral identity. This finding suggests a “target of opportunity” for the development of intervention strategies that mitigate PTSS by addressing the moral dimensions of military service.
Cumulative Blast Impulse Is Predictive for Changes in Chronic Neurobehavioral Symptoms Following Low Level Blast Exposure during Military Training
Authors: McEvoy Cory , Crabtree Adam , Case John , Means Gary E , Muench Peter , Thomas Ronald G , Ivory Rebecca A , Mihalik Jason , Meabon James S
Published: March 2024

Introduction

Cumulative low-level blast exposure during military training may be a significant occupational hazard, increasing the risk of poor long-term outcomes in brain function. US Public Law 116-92 section 717 mandates that US Department of Defense agencies document the blast exposure of each Service member to help inform later disability and health care decisions. However, which empirical measures of training blast exposure, such as the number of incidents, peak overpressure, or impulse, best inform changes in the neurobehavioral symptoms reflecting brain health have not been established.

Materials and Methods

This study was approved by the US Army Special Operations Command, the University of North Carolina at Chapel Hill, and the VA Puget Sound Health Care System. Using methods easily deployable across different organizational structures, this study sought to identify and measure candidate risk factors related to career occupational blast exposure predictive of changes in neurobehavioral symptom burden. Blast dosimetry-symptom relationships were first evaluated in mice and then tested in a military training environment. In mice, the righting time neurobehavioral response was measured after exposure to a repetitive low-level blast paradigm modeled after Special Operations training. In the military training environment, 23 trainees enrolled in a 6-week explosive breaching training course, 13 instructors, and 10 Service member controls without blast exposure participated in the study (46 total). All participants provided weekly Neurobehavioral Symptom Inventory (NSI) surveys. Peak blast overpressure, impulse, total number of blasts, Time in Low-Level Blast Occupation, and Time in Service were analyzed by Bayesian analysis of regression modeling to determine their probability of influence on the post-training symptoms reported by participants.

Results

We tested the hypothesis that cumulative measures of low-level blast exposure were predictive of changes in neurobehavioral symptoms. In mice, repetitive blast resulted in reduced righting times correlated with cumulative blast impulse. In Service members, peak blast overpressure, impulse, total number of blasts, Time in Low-Level Blast Occupation, and Time in Service all showed strong evidence of influence on NSI scores after blast exposure. However, only models including baseline NSI scores and cumulative blast impulse provided significant predictive value following validation.

Conclusions

These results indicate that measures of cumulative blast impulse may have utility in predicting changes in NSI scores. Such paired dosimetry-symptom measures are expected to be an important tool in safely guiding Service members’ occupational exposure and optimizing force readiness and lethality.
Modeling Risk for Lower Extremity Musculoskeletal Injury in U.S. Military Academy Cadet Basic Training
Authors: Hearn Darren W , Kerr Zachary Yukio , Wikstrom Erik A , Goss Donald L , Cameron Kenneth L , Marshall Stephen W , Padua Darin A
Published: March 2024

Introduction

Sport and tactical populations are often impacted by musculoskeletal injury. Many publications have highlighted that risk is correlated with multiple variables. There do not appear to be existing studies that have evaluated a predetermined combination of risk factors that provide a pragmatic model for application in tactical and/or sports settings.

Purpose

To develop and test the predictive capability of multivariable risk models of lower extremity musculoskeletal injury during cadet basic training at the U.S.Military Academy.

Materials and Methods

Cadets from the class of 2022 served as the study population. Sex and injury history were collected by questionnaire. Body Mass Index (BMI) and aerobic fitness were calculated during testing in the first week of training. Movement screening was performed using the Landing Error Scoring System during week 1 and cadence was collected using an accelerometer worn throughout initial training. Kaplan–Meier survival curves estimated group differences in time to the first musculoskeletal injury during training. Cox regression was used to estimate hazard ratios (HRs) and Akaike Information Criterion (AIC) was used to compare model fit.

Results

Cox modeling using HRs indicated that the following variables were associated with injury risk : Sex, history of injury, Landing Error Scoring System Score Category, and Physical Fitness Test (PT) Run Score. When controlling for sex and history of injury, amodel including aerobic fitness and BMI outperformed the model including movement screening risk and cadence (AIC: 1068.56 vs. 1074.11) and a model containing all variables that were significant in the univariable analysis was the most precise (AIC: 1063.68).

Conclusions

In addition to variables typically collected in this tactical setting (Injury History, BMI, and aerobic fitness), the inclusion of kinematic testing appears to enhance the precision of the risk identification model and will likely continue to be included in screening cadets at greater risk.
Efficacy of 1% Clotrimazole Powder Monotherapy for Treating Tinea Cruris: A Comparative Randomized Study
Authors: Ongsri Punyawee , Bangchang Nanchaya Na , Saengthong-Aram Phuwakorn , Leeyaphan Charussri , Pattanaprichakul Penvadee , Bunyaratavej Sumanas
Published: March 2024

Introduction

A rise in tinea cruris among Thai Naval Cadets has been observed. Clotrimazole powder has been shown to be effective as an adjunct treatment for tinea cruris; however, its efficacy as a monotherapy is limited.

Objectives

The aim is to determine the efficacy of 1% clotrimazole cream versus 1% clotrimazole powder in treating tinea cruris.

Material and Methods

A randomized trial was conducted at the Thai Naval Rating School, Chonburi, Thailand. Naval rating cadets with suspected tinea cruris were randomly assigned to one of two groups: 1% clotrimazole cream or 1% clotrimazole powder, and they were instructed to apply the related medication to the affected lesion twice daily for 4 weeks. Clinical and symptomatic evaluations were carried out at 4 and 8 weeks.

Results

All 17 and 14 participants who received 1% clotrimazole cream and powder, respectively, were included. After 4 weeks, the clinical cure rates were 76.5% in the cream group and 85.7% in the powder group (P = .664). All participants were clinically cured within 8 weeks. The self-evaluation of itch severity using a visual analog scale (VAS) revealed no significant difference between the two groups (P = .343). The dermatology quality of life index decreased as clinical improvement was achieved in both the clotrimazole cream and powder groups (6.0 vs. 7.5 score reductions, respectively; P = .765). The score for sweat reduction was higher in the 1% clotrimazole powder group compared to the cream group (5.0 vs. 4.0, respectively; P = .006).

Conclusion

Monotherapy with 1% clotrimazole powder showed comparable efficacy to 1% clotrimazole cream. Furthermore, the powder treatment reduced sweat more effectively compared to the cream.
Exploring Knowledge, Skills, and Abilities Needed for Army Pharmacist Readiness Using the Nominal Group Technique
Authors: Costantino Ryan C , Jung Eulho , Soh Michael , Samuel Anita
Published: March 2024

Introduction

The purpose of this study was to conduct a general educational needs assessment to identify deficiencies in current Army pharmacy education while projecting future educational requirements based on changes in pharmacy practice and evolving demands of military medicine.

Materials and Methods

Twelve pharmacists participated in a facilitated discussion using the nominal group technique. Data were analyzed using quantitative and qualitative methods to establish consensus. Member checking was used to verify and validate the findings.

Results

Participants generated 190 knowledge, skill, and ability (KSA) statements over 3 sessions. Twenty-one statements achieved consensus. Four consensus statements were skills, 7 were knowledge, and 10 were abilities. KSAs were categorized into pharmaceutical care, military, logistics, or legal domain based on a thematic analysis.

Conclusions

With modernized, relevant KSAs, the Army can measure and train a ready pharmacy force. Individual Critical Tasks augmented with KSAs are one potential approach we recommend as a strategy to improve Army pharmacist health profession education.
Occult Lung Cancer–Associated Autoimmune Encephalitis Presenting as Acute Psychosis
Authors: McCarter Shelly K , Shen K Robert , Wylam Mark E
Published: March 2024

During deployment, a 52-year-old male developed acute behavioral changes. Though initially considered to have PTSD and related agitation and confusional state, his evaluation was consistent with acute encephalopathy. Magnetic resonance imaging of the brain showed T2 hyperintensities, and CSF analysis was positive for anti-N-methyl-D-aspartate receptor antibody. A nuclear protein in testis carcinoma midline carcinoma was discovered in the lung. Immunotherapy and surgical resection led to steady improvement prior to adjuvant chemotherapy. Autoimmune encephalitis due to anti-N-methyl-D-aspartate receptor antibodies is increasingly being recognized as causal of acute behavioral change.
The Military–Civilian Partnership Quality Improvement Program Concept: A Process to Improve Data Collection and Outcomes Assessment
Authors: Fox Justin P , Earnest Ryan E , Sams Valerie
Published: March 2024

Introduction

Military–Civilian Partnerships (MCPs) are vital for maintaining the deployment readiness of military health care physicians. However, tracking their clinical activity has proven to be challenging. In this study, we introduce a locally driven process aimed at the passive collection of external clinical workload data. This process is designed to facilitate an assessment of MCP physicians’ deployment readiness and the effectiveness of individual MCPs.

Materials and Methods

From March 2020 to February 2023, we conducted a series of quality improvement projects at the Wright Patterson Medical Center (WPMC) to enhance our data collection efforts for MCP physicians. Our methodology encompassed several steps. First, we assessed our existing data collection processes and their outcomes to identify improvement areas. Next, we tested various data collection methods, including self-reporting, a web-based smart phone application, and an automated process based on billing or electronic health record data. Following this, we refined our data collection process, incorporating the identified improvements and systematically tracking outcomes. Finally, we evaluated the refined process in 2 different MCPs, with our primary outcome measure being the collection of monthly health care data.

Results

Our examination at the WPMC initially identified several weaknesses in our established data collection efforts. These included unclear responsibility for data collection within the Medical Group, an inadequate roster of participating MCP physicians, and underutilization of military and community resources for data collection. To address these issues, we implemented revisions to our data collection process. These revisions included establishing clear responsibility for data collection through the Office of Military–Civilian Partnerships, introducing a regular “roll call” to match physicians to MCP agreements, passively collecting data each month through civilian partner billing or information technology offices, and integrating Office of Military–Civilian Partnership efforts into regular executive committee meetings. As a result, we observed a 4-fold increase in monthly data capture at WPMC, with similar gains when the refined process was implemented at an Air Force Center for the Sustainment of Trauma and Readiness Skills site.

Conclusions

The Military–Civilian Partnership Quality Improvement Program concept is an effective, locally driven process for enhancing the capture of external clinical workload data for military providers engaged in MCPs. Further examination of the Military–Civilian Partnership Quality Improvement Program process is needed at other institutions to validate its effectiveness and build a community of MCP champions.
The Link Between Somatization and Dissociation and PTSD Severity in Veterans Who Sought Help From the IDF Combat Stress Reaction Unit
Authors: Shabat Nizan , Bechor Uzi , Yavnai Nirit , Tatsa-Laur Lucian , Shelef Leah
Published: March 2024

Introduction

This study aimed to examine the relationships between dissociative and somatic symptoms and how they might contribute to PTSD severity among ex-soldiers who sought help from the IDF Combat Stress Reaction Unit (CSRU).

Materials and Methods

This cross-sectional study included 1,305 former compulsory, career, and reserve soldiers, who filled out self-report questionnaires on admission for evaluation at the CSRU. The study’s dependent variables included two posttraumatic stress disorder measures (CAPS and PCL-5). The independent variables were the Dissociative Experience Scale and Brief Symptom Inventory. Background and service-related variables were also examined.

Results

Spearman correlation revealed that the higher the level of somatization is, the higher the level of PTSD via PCL and CAPS. A significant positive association was found between somatization and dissociation (r = 0.544; P < 0.001). The higher the somatization level, the more severe the dissociation. A multivariate logistic regression analysis to predict severe PTSD revealed that the longer the time elapsed from the traumatic event (OR = 1.019, P = 0.015), the higher the risk for severe PTSD. The most prominent variables were dissociation (OR = 6.420, P < 0.001) and somatization (OR = 4.792, P < 0.001). The entire model reached 40.8% of the shared variance in the regression.

Conclusions

While there is direct reference to dissociation in the clinical assessment by PCL or CAPS, there is no such reference to somatization. Highly functioning combatants sometimes express their distress somatically. Our findings suggest regarding severe somatic symptoms as diagnostic criteria for PTSD.
Body Armor and Lumbar Disc Herniation in Young Military Veterans: A Case Series
Authors: Jungong Cheo Akongnwi , Nkemngong Dominic Nkafu , Mortenson Michael
Published: March 2024

Introduction

Soldiers on the battlefield are affected by heavy body armor and excessive march load. It is well known, but the long-term effects of this extra weight on the musculoskeletal system of military veterans, specifically the lumbar spine, are unclear. In Iraq and Afghanistan, most body armors weighed over 33 pounds (15 kg). These armors were 3 times heavier than those used in Vietnam. Chiropractors at the Fargo VA Hospital are seeing more young veterans with non-traumatic lower back pain. This article presents a perspective on the impact of body armor weight and excessive carry load on lumbosacral disc herniation with radicular pain in military veterans.

Materials and Methods

This study is a retrospective case series. We used a convenient sampling method. We selected the first 10 military veterans who came to a Fargo VA chiropractor in late fall 2023. Each veteran filled out a VA Form 10-5345 to give us permission to access their electronic health records. All 10 veterans also completed a survey. The survey asked about their active combat status, the type and weight of their body armor, how long they wore the armor each day, how much weight they carried, and their opinion on the cause of their lower back pain (service related or not). The Fargo VA does not require an institutional review board for a case series.

Results

This study found that military veterans experience lower back pain at an average age of 35 years. This is at least 5 years earlier than non-service men. Lower back pain with disc herniation typically occurs at the L4-L5 and L5-S1 disc levels. All 10 veterans in the study believe that their lower back pain is related to their service. Sixty percent of the participants in the study have a service-connected disability because of back pain.

Conclusions

For military veterans, onset of lower back pain from a disc herniation at a young age may be linked to carrying heavy body armor and loads. However, the small sample size of this case series limits causal relationship inferences.
Antiviral Efficacy Testing of a Rechargeable Textile
Authors: Izadjoo Mina , Carhart Kylin , Marcel Vanessa , Izadjoo Salman , Swicegood Faith , Merritt Casey , Clarke Geroge
Published: March 2024

Introduction

In light of the COVID-19 (Coronovirus Disease 2019) pandemic, the use of personal protective equipment has become essential to reduce viral transmission and maintain public health. Viruses, particularly human coronavirus and influenza, pose significant challenges because of their various transmission routes. UMF Corporation’s innovation, Micrillon, aims to address these challenges by creating durable, antiviral technology for textiles without harmful chemicals, reducing viral transmission risks.

Materials and Methods

The study followed ISO Standard 18184:2019, testing Micrillon textiles against Human Coronavirus OC43 and H1N1 Influenza A virus using MDCK and HCT-8 cell lines. Cell propagation, viral application, TCID50 (Median Tissue Culture Infectious Dose) testing, and maintenance protocols were rigorously implemented to assess antiviral efficacy.

Results

Micrillon gloves, fabrics, and fibers exhibited high antiviral efficacy against both viruses across various contact times. Gloves demonstrated exceptional antiviral activity against H1N1 (99.88%) and OC43 (99.67%) at 120 minutes. Rolled fabrics showed strong efficacy against H1N1 (99.42% at 30 minutes) and OC43 (>97%) at all time points. Bundled fibers displayed substantial efficacy against H1N1 (99.17% at 120 minutes) and OC43 (>98%) at all time points.

Conclusions

The study demonstrates that Micrillon technology effectively inhibits viral activity, particularly in gloves, fabrics, and fibers. The innovation not only shows high antiviral efficacy against both Human Coronavirus and Influenza but also promises a reusable, sustainable solution, mitigating environmental impact and reducing the use of harmful chemicals in personal protective equipment. The technology holds promise for widespread use in health care and hospitality, offering a layer of protection while being environmentally conscious. Further development of such technologies can significantly reduce infection risks while minimizing environmental harm.