bluuebunny/crossref_metadata_2025 huggingface dataset:
Highly Sensitive Virome Characterization of Aedes aegypti and Culex pipiens Complex from Central Europe and the Caribbean Reveals Potential for Interspecies Viral Transmission
Authors: Thannesberger Jakob , Rascovan Nicolas , Eisenmann Anna , Klymiuk Ingeborg , Zittra Carina , Fuehrer Hans-Peter , Scantlebury-Manning Thea , Gittens-St.Hilaire Marquita , Austin Shane , Landis Robert Clive , Steininger Christoph
Published: August 2020

Mosquitoes are the most important vectors for arthropod-borne viral diseases. Mixed viral infections of mosquitoes allow genetic recombination or reassortment of diverse viruses, turning mosquitoes into potential virologic mixing bowls. In this study, we field-collected mosquitoes of different species (Aedes aegypti and Culex pipiens complex), from different geographic locations and environments (central Europe and the Caribbean) for highly sensitive next-generation sequencing-based virome characterization. We found a rich virus community associated with a great diversity of host species. Among those, we detected a large diversity of novel virus sequences that we could predominately assign to circular Rep-encoding single-stranded (CRESS) DNA viruses, including the full-length genome of a yet undescribed Gemykrogvirus species. Moreover, we report for the first time the detection of a potentially zoonotic CRESS-DNA virus (Cyclovirus VN) in mosquito vectors. This study expands the knowledge on virus diversity in medically important mosquito vectors, especially for CRESS-DNA viruses that have previously been shown to easily recombine and jump the species barrier.
In Vitro Evaluation of Farnesyltransferase Inhibitor and its Effect in Combination with 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Inhibitor against Naegleria fowleri
Authors: Hahn Hye Jee , Debnath Anjan
Published: August 2020

Free-living amoeba Naegleria fowleri causes a rapidly fatal infection primary amebic meningoencephalitis (PAM) in children. The drug of choice in treating PAM is amphotericin B, but very few patients treated with amphotericin B have survived PAM. Therefore, development of efficient drugs is a critical unmet need. We identified that the FDA-approved pitavastatin, an inhibitor of HMG Co-A reductase involved in the mevalonate pathway, was equipotent to amphotericin B against N. fowleri trophozoites. The genome of N. fowleri contains a gene encoding protein farnesyltransferase (FT), the last common enzyme for products derived from the mevalonate pathway. Here, we show that a clinically advanced FT inhibitor lonafarnib is active against different strains of N. fowleri with EC50 ranging from 1.5 to 9.2 µM. A combination of lonafarnib and pitavastatin at different ratios led to 95% growth inhibition of trophozoites and the combination achieved a dose reduction of about 2- to 28-fold for lonafarnib and 5- to 30-fold for pitavastatin. No trophozoite with normal morphology was found when trophozoites were treated for 48 h with a combination of 1.7 µM each of lonafarnib and pitavastatin. Combination of lonafarnib and pitavastatin may contribute to the development of a new drug regimen for the treatment of PAM.
Evaluation of Mchare and Matooke Bananas for Resistance to Fusarium oxysporum f. sp. cubense Race 1
Authors: Ndayihanzamaso Privat , Mostert Diane , Matthews Megan Ceris , Mahuku George , Jomanga Kennedy , Mpanda Happyness Justine , Mduma Hassan , Brown Allan , Uwimana Brigitte , Swennen Rony , Tumuhimbise Robooni , Viljoen Altus
Published: August 2020

Fusarium wilt, caused by the soil-borne fungus Fusarium oxysporum f. sp. cubense (Foc) race 1, is a major disease of bananas in East Africa. Triploid East African Highland (Matooke) bananas are resistant to Foc race 1, but the response of diploid (Mchare and Muraru) bananas to the fungus is largely unknown. A breeding project was initiated in 2014 to increase crop yield and improve disease and pest resistance of diploid and triploid East African Highland bananas. In this study, eight Mchare cultivars were evaluated for resistance to Foc race 1 in the field in Arusha, Tanzania. In addition, the same eight Mchare cultivars, as well as eight Muraru cultivars, 27 Mchare hybrids, 60 Matooke hybrids and 19 NARITA hybrids were also screened in pot trials. The diploid Mchare and Muraru cultivars were susceptible to Foc race 1, whereas the responses of Mchare, NARITAs and Matooke hybrids ranged from susceptible to resistant. The Mchare and Matooke hybrids resistant to Foc race 1 can potentially replace susceptible cultivars in production areas severely affected by the fungus. Some newly bred Matooke hybrids became susceptible following conventional breeding, suggesting that new hybrids need to be screened for resistance to all Foc variants.
Why Śrīdhara Svāmī? The Makings of a Successful Sanskrit Commentary
Authors: Gupta Ravi M.
Published: August 2020

Śrīdhara Svāmī’s commentary on the Bhāgavata Purāṇa, called Bhāvārtha-dīpikā and composed sometime between the mid-fourteenth to the mid-fifteenth centuries, has exerted extraordinary influence on later Bhāgavata commentaries, and indeed, on Vaiṣṇava traditions more generally. This article raises a straightforward question: “Why Śrīdhara?” Focusing on the Caitanya Vaiṣṇava tradition, particularly Jīva Gosvāmī, for whom Śrīdhara is foundational, we ask, “What is it about Śrīdhara Svāmī’s commentary—both stylistically and theologically—that made it so useful to Caitanya Vaiṣṇavas and other Bhāgavata commentators?” This question, to the extent that it can be answered, has implications for our understanding of Śrīdhara’s theology as well as the development of the early Caitanya Vaiṣṇava tradition, but it can also lend insight into the reasons for Śridhara’s influence more generally in early modern India.
Spectral–Spatial Features Integrated Convolution Neural Network for Breast Cancer Classification
Authors: Mewada Hiren K , Patel Amit V , Hassaballah Mahmoud , Alkinani Monagi H. , Mahant Keyur
Published: August 2020

Cancer identification and classification from histopathological images of the breast depends greatly on experts, and computer-aided diagnosis can play an important role in disagreement of experts. This automatic process has increased the accuracy of the classification at a reduced cost. The advancement in Convolution Neural Network (CNN) structure has outperformed the traditional approaches in biomedical imaging applications. One of the limiting factors of CNN is it uses spatial image features only for classification. The spectral features from the transform domain have equivalent importance in the complex image classification algorithm. This paper proposes a new CNN structure to classify the histopathological cancer images based on integrating the spectral features obtained using a multi-resolution wavelet transform with the spatial features of CNN. In addition, batch normalization process is used after every layer in the convolution network to improve the poor convergence problem of CNN and the deep layers of CNN are trained with spectral–spatial features. The proposed structure is tested on malignant histology images of the breast for both binary and multi-class classification of tissue using the BreaKHis Dataset and the Breast Cancer Classification Challenge 2015 Datasest. Experimental results show that the combination of spectral–spatial features improves classification accuracy of the CNN network and requires less training parameters in comparison with the well known models (i.e., VGG16 and ALEXNET). The proposed structure achieves an average accuracy of 97.58% and 97.45% with 7.6 million training parameters on both datasets, respectively.
Pre-Impact Fall Detection with CNN-Based Class Activation Mapping Method
Authors: Shi Jingyi , Chen Diansheng , Wang Min
Published: August 2020

In this paper, we report our improvement on the prediction accuracy of pre-impact fall detection by applying a learning-based method on the real-time data from an IMU (inertial measurement unit)-sensor mounted on the waist, making it possible to achieve a high accuracy on a wearable device with the extracted features. Using the fixed threshold method is difficult for achieving satisfactory detection accuracy, due to various characteristics and behaviors in the movement of different individuals. In contrast, one could realize high-accuracy detection with machine learning-based methods, but it is difficult to apply them in the wearable devices due to the high hardware requirement. Our method merges the two methods above. We build a convolutional neural network (CNN) with a class activation mapping (CAM) method, which could highlight the class-specific region in the data and obtain a hot map of the fall data. After training on the MobiAct dataset, the model could achieve high-accuracy detection (95.55%) and obtain the region with high contributions to the classification. Then, we manually extract effective features and characteristics of this region and form our special threshold method, achieving pre-impact fall detection in real-world data. Consequently, our method achieves accuracy of 95.33% and a detection time of within 400 ms.
Optimizations for Energy Efficiency in Software-Defined Wireless Sensor Networks
Authors: Buzura Sorin , Iancu Bogdan , Dadarlat Vasile , Peculea Adrian , Cebuc Emil
Published: August 2020

Software-defined wireless sensor networking (SDWSN) is an emerging networking architecture which is envisioned to become the main enabler for the internet of things (IoT). In this architecture, the sensors plane is managed by a control plane. With this separation, the network management is facilitated, and performance is improved in dynamic environments. One of the main issues a sensor environment is facing is the limited lifetime of network devices influenced by high levels of energy consumption. The current work proposes a system design which aims to improve the energy efficiency in an SDWSN by combining the concepts of content awareness and adaptive data broadcast. The purpose is to increase the sensors’ lifespan by reducing the number of generated data packets in the resource-constrained sensors plane of the network. The system has a distributed management approach, with content awareness being implemented at the individual programmable sensor level and the adaptive data broadcast being performed in the control plane. Several simulations were run on historical weather and the results show a significant decrease in network traffic. Compared to similar work in this area which focuses on improving energy efficiency with complex algorithms for routing, clustering, or caching, the current proposal employs simple computing procedures on each network device with a high impact on the overall network performance.
Can the National Green Industrial Policy Improve Production Efficiency of Enterprises?—Evidence from China
Authors: Liu Pei , Huang Wei-Chiao , Chen Hao
Published: August 2020

This paper examines whether the national green industrial policy (GIP) can effectively optimize the enterprises’ structural transformation and upgrading, and improve production efficiency of enterprises. Using China’s firm-level data from 1998 to 2007, we take the 2003 “Cleaner Production Promotion Law of PRC” as the turning point of GIP implementation, and employ the difference-in-differences (DID) method to explore the policy effect on total factor productivity (TFP) of enterprises. The analysis shows that GIP can enhance the enterprise’s resource allocation capability and TFP growth. The implementation path of policy mainly relies on the compensation mechanism to incentivize innovation and the elimination mechanism of market selection. Specifically, GIP enhances TFP growth by accelerating the dynamic replacement (enterprise entry and exit) and elimination mechanism of the market, and by promoting innovative production to enhance the enterprise’s production efficiency. Further heterogeneity analysis reveals that state-owned enterprises are more susceptible to the influence of GIP, and GIP exerts more restrictive impact on high-pollution industries. Also, GIP has more significant net spillover effect on technology-intensive enterprises. The study provides a reliable factual basis for the market effect of GIP and the direction for green industry development.
Timing of Nephrectomy and Renal Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) in the Era of Living Kidney Donation
Authors: Alkaissy Rand , Schaapherder Alexander , Baranski Andrzej , Dubbeld J. , Braat Andries , Lam Hwai-Ding , Nijboer W. , Nieuwenhuizen J. , de Vries Dorottya , Huurman Volkert , Alwayn Ian , van der Bogt Koen
Published: August 2020

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common hereditary disorders. Once progressed to end-stage renal disease, kidney transplantation may be needed. Whether and when to perform a (bilateral) native nephrectomy in case of end-stage renal failure are issues under debate. At our institution, with a growing number of living kidney donations, the general trend is to perform a native nephrectomy prior to transplantation. Our aim was to compare the outcomes of this approach to a nephrectomy during or after transplantation and to compare our findings to results reported in the literature. Data were prospectively collected from all ADPKD patients undergoing native nephrectomy and kidney transplantation at the Leiden University Medical Center between 2000–2017. A literature search was performed in the PubMed and Scopus databases. The clinical results were retrospectively reviewed and were stratified according to the timing of the nephrectomy. From the literature review, the most practiced approach was a combined unilateral nephrectomy and kidney transplantation. However, in our series, the favored approach was to perform a scheduled bilateral nephrectomy prior to kidney transplantation. A total of 114 patients underwent a native nephrectomy prior to (group 1, n = 85), during (group 2, n = 5), or after (group 3, n = 24) kidney transplantation. There were no statistically significant differences in postoperative morbidity after nephrectomy nor differences in kidney transplant outcome. Bilateral nephrectomy prior to kidney transplantation is a safe, controlled approach carrying minimal complication and mortality rates and facilitating a subsequent transplant procedure without mechanical or hemodynamic limitations for the graft.
Patient-oriented approach during the early postoperative period in the specialized health care organization
Authors: Dvoynikov S. , Bogush E.
Published: August 2020

The paper describes a patient-oriented approach for a nurse with the expansion of functional responsibilities in the context of a new organizational model. Emphasis is made on the timely identification of patient problems and prevention of complications, as shown on the example of the early postoperative period in a specialized health care organization.
Role of district nurse in the organization of care for elderly and senile patients with dementia
Authors: Melkina L.
Published: August 2020

The article is devoted to the study of the problem of dementia in elderly and senile patients and the role of the district nurse in organizing care for patients and helping family members at home. In the practical part, the organization of work in the district and the analysis of statistical indicators in the district for 2018 are shown. Information material for patients and their families in the form of information notes have been created as a result of the work.
Contents of the standard operating procedure «Operating procedure of using Easy Move patient transfer system for the bed bound patients»
Authors: Bogush E. , Pyatikop V.
Published: August 2020

This standard operating procedure (SOP) determines the order of transfer (by rolling) of bed bound patients, intended for doctors, paramedical and nursing staff of the Samara Regional Clinical Oncology Center.
Prevalence of depressive spectrum disorders among college students
Authors: Fomichev D.
Published: August 2020

The article presents an analysis of the prevalence of depressive spectrum disorders among college students in Samara. Questionnaire data that allow to draw conclusions about the prevalence of depressive spectrum disorders in the student community and propose preventive measures within the vocational education organizations are presented.
Labour disputes among the nursing staff
Authors: Karasyova L.
Published: August 2020

The article presents results of research work that allow to assess the likelihood of conflict in the work teams of inpatient departments, to assess the conflict resistance of nursing staff in the process of professional activity and to analyze the impact of elements of the quality of working life on the formation of conflict-generating issues.
Effective cooperation
Authors: Vahgina E.
Published: August 2020

The article presents the effective experience of cooperation of two non-governmental organizations in the Nizhny Novgorod region: Professional Association of Specialists with Higher and Secondary Medical and Pharmaceutical Education and National Association of Specialists for the Control of Healthcare-Associated Infections.
Establishment of a reserve of managers of nursing services (on the example of medical organizations of the Samara region)
Authors: Ayzyatova E.
Published: August 2020

Factors preventing the formation of a personnel reserve of nursing managers in medical organizations were studied and criteria for assessing the qualifications of a candidate for the reserve were identified.
System of records management in the ystem of records management in the professional activity of heads of nursing rofessional activity of heads of nursing services ervices
Authors: Arkhipova S.
Published: August 2020

The purpose of the study was to determine the level of knowledge and skills in the processing of documents accompanying the professional activities of heads of nursing services.
Tuberculosis and HIV — infection in psychiatric hospital environment
Authors: Ovchinnikova Oksana
Published: August 2020

Quantitative comparative statistics of data for twenty-one treatment units of GBOZ «SOKPB» have been carried out. Data of clinical picture, clinical laboratory studies of patients have been studied. Records of the disease have been monitored and history data have been studied. The results of the survey were analysed.
Acute bronchitis in nursing practice cute bronchitis in nursing practice
Authors: Skvortsov Vsevolod , Lipov Daniil , Muradova Khedi
Published: August 2020

Acute bronchitis (AB) is an inflammatory process in the trachea, bronchi or bronchioles, characterized by acute course and diffuse reversible lesion, mainly of the mucous membrane. To date, there are a number of criteria for diagnosis, and treatment of this pathology. The article tells about the principles of classification, etiology, pathogenesis and the basic principles of treatment of acute bronchitis.
With mercy and compassion through the ages ith mercy and compassion through the ages
Authors: Kropotova Svetlana
Published: August 2020

The article gives insight into the history of the creation of the nurse business, the outstanding representatives of the sisters of Mercy are mentioned, the importance and significancy of nursing practice for assisting those who need it is emphasized.
Experimental study of post-traumatic stress disorder in military personnel participating in combat operations (research results)
Authors: Menzul Elena , Ryazantseva Natalya , Karaseva Larisa
Published: August 2020

Theoretical significance of the research is represented by the definition of peculiarities related to impairment of adaptive capabilities in individuals who arrived from war zones; practical significance lies in the data obtained in the course of research – they allow to plan psycho-correction for the wounded and affected people from the war zone.
Peculiarities of patient care
Authors: Bogush E.
Published: August 2020

The purpose of the work is to determine the sequence of actions during care after the patient with oncology in order to maintain his or her quality of life.
Continuous professional development of nursing staff — optimization of work of teaching and methodical cabinet
Authors: Inozemtseva Svetlana , Karaseva Larisa
Published: August 2020

In modern conditions, nursing is considered to be an essential component of the health care system. The range of functions of nursing staff has now been considerably expanded, and the degree of responsibility of nurses for the patient and the quality of the services provided by them has increased. In the current situation, the importance of continuing education of secondary medical workers on the basis of educational and methodological offices of medical organizations is increasing.
Professional activity of the expert
Authors: Karaseva Larisa
Published: August 2020

The professional activity of secondary health workers requires them not only theoretical and practical training, but also attentive to their physical and mental health. The article draws attention to professional risks that can and should be managed.
Contents of standard operating procedure «Hygienic processing of hands»
Authors: Dashuk Svetlana
Published: August 2020

This standard operating procedure (SOP) defines the establishment of uniform requirements to compliance with the procedure for carrying out hygienic treatment of hands, has been introduced into the practical activities of medical workers of Tolyattin dental polyclinic No. 3.
Infectious safety of patients in the provision of prehospital care for burns
Authors: Dmitryeva Marina
Published: August 2020

The article describes the measures taken by medical professionals of emergency medical care to observe infectious safety of patients in the provision of pre-medical care in case of burns.
Problems of processing a rigid endoscope with ambulatory ent manipulations
Authors: Fedorinova Svetlana
Published: August 2020

The article presents information on the stages and peculiarities of processing rigid endoscopes in the provision of outpatient medical care in the otorhinolaryngological service.
To the question of the performance of prevention of the syndrome of emotional burning from dentists
Authors: Setko Nina , Bulycheva Ekaterina
Published: August 2020

The article shows that the symptomatic pattern of emotional burnout syndrome in dentists of surgeons, therapists and orthopedists was characterized by the formation of 2 symptoms «Self-dissatisfaction» and «Emotional deficiency» and formation of 1 symptom among surgeons «Emotional moral disorientation «to 2 symptoms among orthopedists «Expansion of the sphere of saving emotions», «Inadequate emotional response». With the increase in the length of service among dentists, the expression of 3 symptoms among orthopedists up to 6 symptoms among the surgeons of the syndrome of emotional burnout increases 1.5–3 times.
Factors of mental stress in a situation of assessing knowledge
Authors: Menzul Elena , Ryazantseva Natalia , Fomichev Danil
Published: August 2020

The educational space of the school causes a complex of non-uniform problems, one of which is the presence of destructive mental states in students in the educational process. Schooling requires students to have a significant intellectual and emotional mental strain, reaching to the limits of opportunity during control jobs, credits and exams. The reasons for destructive mental states arising in the educational process, experts see the mismatch of the level of requirements of the pedagogical process with the level of cognitive capabilities of students, authoritarian position of the teacher, large volume of material and lack of time for its study, reduction of the level of motivation to study due to dissatisfaction with teaching methods, etc. That is why, in our view, the study of the influence of personal features of high school students on nervous-mental tension is very relevant.
Influence of a smartphone on human health
Authors: Kropotova Svetlana , Shitova Anastasia
Published: August 2020

Every year smartphone manufacturers produce increasingly new models. And every such innovation changes our lives, simplifying it on the one hand and complicating it on the other. The article presents the results of research work on the advantages and disadvantages of smartphones revealed during their operation.
Diabetic nephropathy in the nurse practice
Authors: Muradova Hedy , Skvortsov Vsevolod
Published: August 2020

Diabetic nephropathy (DN) is a clinical syndrome characterized by kidney lesions and formation narrow or diffusion glomerulosclerosis, which later becomes kidney failure. It is manifested by persistent albuminuria (>300 mg/day or >200 μg/min), that is confirmed on at least 2 occasions 3–6 months apart, with a progressive decrease in glomerular filtration rate (GFR) and elevated arterial blood pressure (BP).
Gender characteristics of auto-aggressive behavior in older adolescents (literature review)
Authors: Ryazantseva Natalia , Menzul Elena , Fomichev Danil
Published: August 2020

In recent years, there has been a steady decrease in the average age of autoaggressors and an increase in the diversity of forms of autoaggressive behavior. In adolescence and youth, the forms and degrees of autoaggression are most diverse. It is at this age that the most pronounced tendency to re-commit autoaggressive acts is observed, cliched reactions are easily formed and fixed, and auto-aggression is a consequence of the formation and development of a certain «life scenario» — socially determined behavior strategies. The relevance of the study of auto-aggressive behavior is determined by its high prevalence, continuous ubiquitous growth, the complexity of diagnosis and the low effectiveness of prevention.
Infections caused by medical products at longterm nursing care
Authors: Panknin Hardy Thorsten
Published: August 2020

Nosocomial infections in the elderly, often suffering from many ailments, patients in homes for the disabled and the old are among the problematic diseases that specialized nursing staff and doctors have to deal with more often in such institutions. Review work from the USA introduces relevant information about infectious risks, as well as possible preventive and therapeutic measures.
Contents of the standard operating procedure «Regulations of the Work of the Technical Gateway to Ensure the Uninterrupted Work of the Quarantine Zone»
Authors: Radulova Natalya
Published: August 2020

This standard operating procedure (SOP) defines the operating procedure for a technical gateway (sanitary inspection room) to ensure uninterrupted operation of the quarantine zone, SOP is introduced into the practice of medical workers of the multidisciplinary COVID-hospital.
Contents of the standard operating procedure «Donning and Doffing Procedure for Protective Garment when Working with a Patient with a New Coronaviral Infection (COVID-19)»
Authors: Bogush E.
Published: August 2020

This standard operating procedure (SOP) determines the donning and doffing procedure for protective garment when working with a patient with a new coronaviral infection, SOP is introduced into the practice of medical workers at the multidisciplinary COVID-hospital.
Role of nursing staff in organizing and giving ole of nursing staff in organizing and giving lessons for tuberculosis patients
Authors: Lyapina Irina , Karaseva Larisa
Published: August 2020

The article emphasizes the importance and necessity of establishing a School for Tuberculosis Patients. The results of the questionnaire of medical nurses and patients of the anti-tuberculosis clinic are presented to the readers. The author shares the experience of organizing the School and draws attention to the fact that the best means of safety for the medical worker and the patient in the medical organization is competent actions of all participants of the process.
Principles of professional cleaning of premises rinciples of professional cleaning of premises of a medical organization
Authors: Pyatikop V.
Published: August 2020

Cleaning in medicine is a relatively new concept, providing professional cleaning of premises of medical and prophylactic institutions. The main purpose of professional cleaning is careful removal of dust and various organic contaminants, which is important for sterility, cleanliness of medical rooms and safe hospital environment. This article presents a brief experience of introducing professional cleaning of premises in the "Samara Regional Clinical Oncology Dispensary", which confirms the cost-effectiveness and safety of modern technology for patients and medical workers.
Assessment of health ssessment of health condition of medical staff
Authors: Dvoinikov Sergey
Published: August 2020

According to literature data, an increase in the overall disease incidence of medical workers has been recorded in Russia over the past ten years. At the same time, it is noted that the incidence rates obtained from the official reporting data are several times lower than those obtained in the course of sociological surveys. This is due to the fact that medical workers prefer to treat themselves or receive medical care from their colleagues without registering a case of the disease in medical documentation [2, 3].
Assessment of the risk of developing complications ssessment of the risk of developing complications of chronic cholecystitis by a medical assistant of f chronic cholecystitis by a medical assistant of independent practice ndependent practice
Authors: Burlova Natalia
Published: August 2020

The purpose of the study was to justify a model, a personified assessment of the risk of developing complications of chronic cholecystitis based on mathematical modeling. The factors were identified and their impact on the risk of developing complications of chronic cholecystitis was assessed based on a systemic multivariate analysis. Results. It has been established that based on the analysis of risk factors for complications of chronic cholecystitis, using the method of formalized assessment, the medical assistant of independent practice has the ability to create an individual (personal) prevention program. Conclusion. Further study of the application of the method of formalized assessment in the analysis of risk factors for the development of diseases of the digestive system is necessary. Individualization of approaches to preventive work will make it possible to more efficiently organize patient-oriented delivery of medical care in the context of primary health care.
Working of an oncological surgical nurse in the prevention of postoperative complications after undergoing radical mastectomy
Authors: Fedosova Natalya , Volodin Anatoly
Published: August 2020

The article presents the results of a study conducted to determine the effect of the organization of nursing care on reducing the duration of the postoperative period in women who underwent radical mastectomy.
Contents of the preparing a deceased coronavirus (covid-19) patient’s body for transfer to the pathology department by an authorized healthcare provider standard operating procedure
Authors: Radulova Natalya
Published: August 2020

This standard operating procedure (SOP) determines the procedure for preparing the body of a deceased person with a coronavirus infection (COVID-19) for transfer to a pathological department of the authorized medical organization.
Bedsore — «heavy cross» of nursing care
Authors: Hartmann Paul
Published: August 2020

Bedsores are still among the risks that most seriously impair the health of patients who need help and nursing care. Taking into account the existing knowledge about the possibilities of bedsore prevention, we can say that the goal of nursing care is to limit the development of bedsores as much as possible. At the same time, it is of great importance to ensure the continuity of preventive measures by specialized nursing staff. This includes, among other things, systematic risk assessment, training of patients and their relatives, encouraging them to exercise as much as possible, and, most importantly, taking measures to eliminate tissue compression. due to the increasing number of elderly people with multiple diseases considered to be the main risk group, the prevention and treatment of bedsores remains a priority among nursing care activities and requires effective management.
Expanding the role of nurses in prevention of complications in patients with atrial fibrillation
Authors: Inozemtseva Svetlana , Glazkova Eugenia , Ferens Svetlana , Kuznetsova Anna
Published: August 2020

The important problem in the prevention of complications of diseases connected to cardiac rhythm impairment is a low level of knowledge of our patients and lack of self-analysis and self-control skills. In the article, the authors share their experience in solving the priority problems of atrial fibrillation patients.
Nursing administrators' using the system approach in evaluation of ongoing professional education of nurses
Authors: Burlova Natal'ya
Published: August 2020

Purpose of the study was the substantiation of using the model, personalised evaluation of the results of ongoing medical education of middle-level specialists for the subsequent planning of a specialist's educational paths based on multi-factorial analysis. Results. It has been established that using the model based on mathematical modelling allows monitoring the ongoing professional development of each specialist, drawing up a plan based on data on how to create an individual educational path according to the most significant factors improving the result of ongoing medical education. Conclusion. The further studying of using the method of the formalized evaluation into the evaluation of the results of ongoing medical education is necessary.
Influence of a nurse's personality on occupational aptitude for a pediatric inpatient facility
Authors: Muntyan Irina , Kropotova Svetlana
Published: August 2020

A nurse's work scope varies with the department she is employed in. This scope depends on the particular features of dealing with different patient populations. Work in a pediatric inpatient department involves some specific features that distinguish it from operations in any other healthcare facility, which determined the relevance and choice of the scientific research topic.
Application of AlphaLISA in bioanalysis
Authors: Cherepushkin Stanislav
Published: August 2020

The use and development of biotherapeutics increases and the need for accurate, sensitive and robust bioanalytical methods is also increasing. ELISA and other ligand-binding assays are the most widely used methods for the quantification of macromolecules in complex biological samples. One of the alternatives to ELISA is AlphaLISA — a versatile chemiluminescent ligand binding assay using a homogeneous no-wash protocol. AlphaLISA assays are suited for automation and exhibit high sensitivity, high throughput and wide analytical range. Since the early 2000s, this method has been used in science, medicine, and drug development for wide variety of applications, including the quantification of analytes, immunogenicity, protein-protein interactions, enzyme activity, post-translational modifications and epigenetics. In this review, we describe the principles of the AlphaLISA assay and its application in bioanalytical studies (pharmacokinetics and immunogenicity) and high-throughput screening in drug development, medical diagnostics and pathogens detection.
Information and analytical support for pharmaceutical production
Authors: Krasnyuk Ivan , Demina Natalya
Published: August 2020

Operation of modern pharmaceutical enterprise is impossible without information and analytical support providing prompt access to information, its analysis and the use of data for the functioning of enterprise. Structure of pharmaceutical enterprise includes divisions, which are often remote from each other. Centralized administration of their concerted activities, day-to-day communication, information transfer are important objectives of production meeting the requirements of international standards. Today, these issues are solved with the help of information technology providing collection and analysis of information necessary for sound management decisions and implemented on the basis of modern computer technology and modern means of communication.
Issues of co-financing of drug provision for the population: international and Russian practice
Authors: Ryazhenov Vasiliy , Andreyeva Victoriya , Zakharochkina Elena
Published: August 2020

Russian President Vladimir Putin defined increase in life expectancy from 72.7 to 78 years by 2024 as a national aim in the Decree № 204 of May 7, 2018. Achievement of this aim depends on drug provision system among other factors. Strategy of drug provision for the population of the Russian Federation for the period until 2025 sets the goal of increasing availability of high quality, effective and safe medicines to meet needs of the population and the health system based on the formation of a rational and balanced system of drug provision for the population of the country with available resources. The health care system should expand the possibilities of using modern and effective mechanisms to ensure the financing of drug provision for the population.
Pharmacoeconomic analysis of using genetically engineered biologic drugs for treating adult patients with moderate to severe plaque psoriasis in the Russian Federation
Authors: Frolov Maksim , Rogov Vladimir , Salasyuk Alla
Published: August 2020

The aim of the study was to assess clinical and economic effectiveness of netakimab compared to other genetically engineered biologic drugs (infliximab, adalimumab, etanercept, ustekinumab, secukinumab, ixekizumab, certolizumab pegol) for the treatment of adult patients with moderate to severe plaque psoriasis. We have conducted cost-benefit analysis, cost-minimisation analysis, and budget impact analysis. We have considered only direct medical costs. The results of the study show that netakimab has higher or comparable efficacy and significantly lower costs compared to other biologic drugs, that makes it the most preferable treatment option for patients with moderate to severe plaque psoriasis. Use of netakimab in clinical practice will significantly reduce budget expenditures and increase patient access to biologic therapy.
Selectivity regulation of perovskite-based iron-manganese catalysts for the synthesis of light olefins from CO, CO2 and H2
Authors: Kovaleva Anastasiya
Published: August 2020

There is a solution to prevent global problems caused due to carbon dioxide increase in planet atmosphere – reuse of CO2 in hydrogenation reaction. Literature analysis provides information about catalytic conversion of synthesis gas and carbon dioxide to carbohydrates in modern catalytic systems. Actual investigation of catalytic properties in GdFeO3 and GdMnO3 systems with perovskite structure has been carried out in the joint hydrogenation of carbon mono- and dioxide. Scientific novelty of research is to determine influence of the catalyst composition and reaction medium composition on the selectivity of target products.
Microemulsions based on polyglycerol polyricinoleate as drug delivery systems
Authors: Sedyakina Natalya , Feldman Nataliya , Lutsenko Sergey
Published: August 2020

The aim of the work is to develop composition of reverse microemulsion stabilized by the surfactant from a number of polyglycerol polyricinoleates for encapsulating water-soluble biologically active substance (BAS) and studying the kinetics of its release into the medium simulating the medium of the small intestine. Materials and methods. Possible stable (equilibrium) phases of the reverse microemulsion in the pseudoternary system water–PG-3-PR/Tween 80–paraffin oil were determined by titration of surfactant/co-surfactant mixtures–oil in water with hydrophilic-lipophilic balance (HLB) values of the surfactant mixture ranging from 4.0 to 7.0. Stability of a number of compositions during storage at 20 °C for 6 months was studied. Based on the obtained data, a composition was selected for encapsulating methylene blue (MS) dye as a model of a water-soluble biologically active substance. Microemulsion was obtained by mixing paraffin oil and surfactants with selected mass ratio followed by the addition of an aqueous phase. Reverse microemulsion morphology was evaluated with transmission electron microscopy (TEM). To evaluate the in vitro drug release rate, aliquots of an aqueous dye solution (control sample) and MB-containing microemulsions were placed in dialysis bags and immersed in 0.01 M phosphate-buffered saline (PBS) (pH 7.4) in a thermostatic shaking incubator at 180 rpm and 37 °C. Aliquots of the release medium were selected at predetermined time intervals and the concentration of MB dye was determined using a UV spectrophotometer at 660 nm. Results. Composition containing 13.5 wt% paraffin oil, 76.5 wt% mixture of PG3-PR/Tween 80 (HLB 5.5) and 10 wt% water was chosen to encapsulate the biologically active agents. Number average droplet diameter in the dispersed phase of the obtained microemulsion was 55 nm. Dye-loaded microemulsion sample showed a prolonged release of biologically active substances within 48 hours of the experiment (15.2%) and low initial release rate. Conclusion. Possible stable phases of reverse microemulsion in the pseudoternary system water–PG-3-PR/Twin 80–paraffin oil were determined in the course of the work and optimal microemulsion composition for encapsulating medicinal substances was found. It was shown that the resulting microemulsion system provides a sustained release of methylene blue as a model of a water-soluble biologically active substance in a medium simulating medium of the small intestine. The obtained data allow to consider this composition as a potential nanoscale system for the sustained delivery of water-soluble drugs.
Historical use of alder raw materials
Authors: Vasalatiy L. , Kostikova E.
Published: August 2020

The article is devoted to historical use of various alder raw materials: fruits, leaves and bark. Data on the pharmacological properties of the plant are studied, experience of using its preparations in traditional medicine, homeopathy, and cosmetology is considered. It is concluded that alder species are promising plants for study.
Office manager: risks of sedentary lifestyle
Authors: Grigorieva Victoria , Yankowa Victoria
Published: August 2020

A modern person sedentary lifestyle has become very common. There is substantial number of office employees in megapolises. However, sedentary work causes health risks for many employees associated with many diseases. Health problems, associated with musculoskeletal apparatus, ophtalmological, gastrointestinal disesases, varicosity, hemorrhoids are often associated with office work. The objective of the article is to review occupational diseases and common drugs for treatment sedentary lifestyle modern office manager various diseases.
Suicide gene therapy for caner: HSVtkGV and possible delivery systems
Authors: Perepelkina Polina , Sologova Susanna
Published: August 2020

Genotherapeutic drugs are promising group of drugs for oncologic and familiar genetic disorders which are limitedly marketed at present. Anti-cancer gene therapy, using gene killer and enzyme prodrug system demonstrates promising results in preclinical trials. 2 types of carriers are used to deliver genes in a living organism — viral and non-viral, both of them have advantages and disadvantages.
Protein modeling by homology using the example of tick-borne encephalitis serine protease NS3
Authors: Ilment Nikita , Zinina Ekaterina
Published: August 2020

Homology modeling is a process of obtaining a 3D structure of a protein using various algorithms based on already known structures of homologous proteins. The spatial structure of protein is required for in silico protein evaluation. 3D structures can be obtained using different methods: NMR, Xray crystallography (XRC), and cryo-electron microscopy (cryo-EM), but these methods require a lot of time and money. At the same time, the speed of nucleotide sequences analysis is increasing, thereby creating a mismatch between the number of decoded genomes and the investigated 3D protein structures that are encoded by these sequences. Also, homology modeling is the easiest and fastest way to obtain the model of the desired protein. This review describes free software for homology modelling — SWISS-MODEL and MODELLER, how to use it and how to evaluate the results.
Modern Problems of Activity of Guardianship and Custodianship Bodies
Authors: Veretennikova Yulia , Vildanova Gyuzel
Published: August 2020

Various state authorities take an active part in ensuring the protection of families at the state level, in particular, guardianship and custody bodies perform special tasks to protect the rights and legitimate interests of minor children. This article covers the analysis of the main problems in the activities of guardianship and custody bodies.
Basic Forms of Leisure Activities of the Elderly People of Altai Region
Authors: Kolesnikova Olga , Latkina Anastasiya
Published: August 2020

The problems of elderly people concern not only themselves, but also the state and society in general. That is why at present our country gives great importance to the development of social services. In this article the authors present the results of a sociological study which purpose was to determine the forms of leisure activities of the elderly people in the Altai Region.
Organization of Individual Counselling of Children Brought up in Foster Families (on the example of the «Family» Centre»)
Authors: Fazlyeva Aygul , Akhmetshina Aliya
Published: August 2020

Children, brought up in foster families, experience various problems (diffi culties in interpersonal relationships with parents, diffi culties in communicating with peers, emotional instability), which lead to confl icts, quarrels, running away from home, destructive phenomena, etc. One of the eff ective forms of working with children brought up in foster families is individual counselling. Individual counselling is used by various specialists (psychologists, educators, psychotherapists), where a special place is taken by a social educator. His or her activity involves the implementation of social-protective, preventive, educational, informational, advisory functions. In the process of organizing individual counseling, the social educator takes into account the social situation of the family and the child, personal characteristics, social conditions, social and cultural characteristics and the nature of the relationship with the social environment. To organize individual counseling, a social educator needs to master various and eff ective techniques, and take into account a number of recommendations. An analysis of the literature and practical socio-pedagogical experience led to an understanding of the insuffi cient degree of elaboration of this issue. The purpose of this article was the solution to this problem.
Fish population of the Seim river within the borders of the Kursk region
Authors: Bykov A.
Published: August 2020

The article presents the results of ichthyological research on the Seim river within the borders of the Kursk region. It shows the occurrence of fish in the catches of stakes, ring nets and small fry. A list of fish and round-mouthed fish that live in the Seym river at the present time. The issue of occurrence in ichthyocenoses of mass, common, rare rheophilic and invasive fish in the Seim river basin is considered