bluuebunny/crossref_metadata_2025 huggingface dataset:
Age of Productive Life and Milk Yield Level in Holstein Dairy Cows in Bulgaria
Authors: Angelova Teodora Spasova
Published: August 2022

The aim of the present study was to establish the age of productive life and milk yields of different lactations in Holstein cows, born in the period from 2010 to 2017 using the Test day approach. The object of the study are cows of the Holstein dairy breed, bred on 18 farms in different regions of the country. An analysis of 333,721 records of milk productivity data for the control day was performed for 22,464 animals born in the period 2010-2017. The data for the records of origin and productivity are provided by ARCHSHPB - Dobrich. To analyze the factors influencing the assessed traits - milk yield for the control day, fat and protein content, a mathematical model was formulated based on the following hypothesis: variation in milk yield and quality of milk for the control day is caused by genetic and environmental factors - individual, consecutive lactation, farm, breeder, month of production, effect of the genetic value of the individual and random, not studied and described in the model, factors. A control day model was used in which each daily milk control was considered as a separate observation. The data processing was performed using the software products Pest (Groeneveld) and SYSTAT 13. The number of animals that attained 4th and subsequent lactation was low. The influence of the environmental factor farm on the three studied traits was very significant. The sire, test-day month and parity has statistically significant influence on milk yields. The highest average daily milk yield in cows was observed during the third lactation. Neither milk fat nor milk protein contents demonstrated consistent variations.
Blood Culture Reports Utilization in Management of Blood Stream Infections in Tertiary Care Hospital, South India
Authors: Balaji Ragupathy Vikram
Published: August 2022

The choice of antimicrobial therapy for bloodstream infection is often empirical and based on the knowledge of local antimicrobial activity profiles of the most common bacteria causing infections. This study was conducted at Government Vellore Medical College Hospital to correlate the antibiotic sensitivity pattern with the empirically chosen antibiotics by the clinicians to treat blood stream infections and the change of antibiotic according to the sensitivity pattern. The aim of this work to assess whether antibiotics were changed after receiving blood culture reports by the clinicians. Out of 122 patients included in the study, antibiotics were changed in 107 patients (88%) after the issue of the sensitivity report. The clinical condition of the patient improved with the administration of antibiotics recommended as per the sensitivity report. Mortality was significantly reduced in strictly following the sensitivity pattern. Action plan to educate about Antibiotic choice of bloodstream infections as per Hospital Antibiotic policy of the Hospital, to implement change of antibiotics following reports as per Hospital policy and periodic surveillance regarding sustenance of the Antibiotic policy norms.
Existing Knowledge of the Rural Adolescent Girls Regarding Different Aspects of Health Practices
Authors: Rajvi Jyoti , Sareen Neena
Published: August 2022

Adolescent is the period of transition between childhood to adulthood occurring between 11-17 years of age. The study was conducted in Bikaner district. Studies have shown that Bikaner district of Rajasthan is one of the backward desert districts in terms of female education (27.03%) and female health facilities. The marriage age of girls in the district is around 15 years and female by the age of 19-20 years become mother of 3-4 children. The status of women and adolescent girls is miserable. They suffer from anemia and malnutrition. So there is a need to educate the adolescent girls in the district to improve their health status. List of villages having senior secondary Co-education and girl’s government schools will be prepared from selected panchayat samities as our respondents are adolescent girls. Two villages from each panchayat samiti will be selected randomly. List of school going and non-school going adolescent girls of 11-17 years will be procured from school and anganwadi centers /gram panchayat. Fifty girls from each village will be selected randomly having 25 school going and 25 non-school going girls thus comparing the sample of 400 girls.
Effect of Drought Stress and Mineral Nutrition in Plant Growth and Development
Authors: Naik Pavan Kumar , Ruban J. Sam , Naidu S. Alekya , Fetricia J. Preethi
Published: August 2022

Drought is most important abiotic factor which cause significant loss in crop production, declines the economy of a crop. Decreasing the climate change will leads to increasing the drought, so food production also decreases in agriculture. During seed development drought stress reduces the photosynthetic rate of lead and chlorophyll content. Drought shows the drastic effect on mineral nutrition in plants. It reduces the uptake of nutrients from root to the shoot by reducing the rate of transpiration. The aim of essential nutrients are not only for better plant growth and development, also helps to improve from drought stress. Reducing harmful influences on drought stress can be reached by better nutrient achievement.
Evaluation of Machine Learning Classifiers for Crop Classification – A Case Study of Veppanthattai Taluk, Perambalur District
Authors: B. Linda Theres Sakthivel
Published: August 2022

India is a country that has major dependence on agriculture. In spite of all the careful measures, there is a loss of agricultural land due to improper use of land. One way to tackle the issue is hand, is by monitoring and quantifying the crop. Also, Crop discrimination and Acreage estimation are essential for planning and policymaking at various administrative levels. In earlier days, a field-based survey was executed with meddlesome factors like time consumption, and labor-intensive. But with remote sensing and GIS technology in the picture, the survey became a cakewalk. It can provide timely and accurate crop inventory information. Also, with a focus on Machine Learning in recent years, crop classification became more precise. The main objective of this study is to evaluate the performance of Maximum Likelihood Classification (MLC), Minimum Distance to Mean classification (MDMC), Support Vector Machine (SVM) classification, and Neural Net (NN) classification for crop discrimination and acreage estimation in Veppanthattai Block of Perambalur District in Tamil Nadu using Sentinel 2B. Ground truth data were collected randomly over the study area, in that 60% of data used for training and 40% data was used for testing the classification. It was inferred that MLC was the best with a kappa coefficient of 0.89, compared with MDMC, SVM, and NN which exhibited poor classification results with a kappa coefficient of 0.47, 0.85, and 0.83 respectively.
Effect of Plant Growth Regulator and Nutrients on the Vegetative Growth of Potted Bromeliad (Aechmea gamosepala albo marginata)
Authors: Mane Priyanka Sunil , Haldavanekar P. C. , Mali P. C. , Mane A. V. , Parulekar Y. R. , Narute T. , Kadam M. S.
Published: August 2022

The present study was conducted at Department of Floriculture department, College of Horticulture, Dr. Balasaheb Sawant Konkan Krishi Vidyapeeth, Dapoli (MS.) during year 2019-2020. The growth parameters were recorded periodically at 30 days intervals and root parameter was recorded at the end of experiment. From the present investigation it was recorded that the highest shoot length (47.94 cm) was found in Ethrel @ 500 ppm and 19:19:19 @ 1%. The highest length of leaves (43.91 cm), width of leaves (10.36 cm), number of leaves (20.93) was observed in ethrel @ 500 ppm and urea @ 2%. The highest leaf area (705.23 cm2) and leaf area index (0.38) was obtained in @ 500 ppm and urea @ 2%.
Influence of Double Pruning in a Year and Fertilizer Application Time on Growth and flowering Behaviour of Phalsa (Grewia asiatica L.) cv. Local
Authors: Mahida Shailendra V. , Shah Nitin I. , Patel Hiral R.
Published: August 2022

The present investigation entitled Influence of double pruning in a year and fertilizer application time on growth and flowering behaviour of phalsa (grewia asiatica L.) cv. Local was carried out in the year 2019 at horticultural research farm, Anand Agricultural University, Anand. The experiment was carried out with ten treatment combinations of two factors i.e. Five levels of different sets of double pruning and two levels of fertilizer applications time in CRD (Factorial) design. Study showed results that treatment P1i.e.double pruning during August and January was found significant with maximum length of shoot at harvest (94.37cm) and minimum days taken to flowering (42.75), while treatment P5 i.e. double pruning during December and May found significant with minimum days to sprouting new shoot (6.81). Growth parameter such as number of sprouted shoot per cane showed non-significant effect. Fertilizer application time was found no significant effect for all parameters.
Buffaloe Mammillitis: A Systematic Review
Authors: Vinay P Tikare B. Shridhar , Mahesh Kadagi C. N. Santhosh Kumar , Anurag Borthukar Sunilchandra
Published: August 2022

Mammillitis is a condition that causes sudden teat inflammation, enlargement, difficulty milking, difficulty suckle, and the formation of black necrotic patches with circumscribed necrotic areas on the teat base in she buffaloes. It is a disease of buffaloes associated with bovine herpes mammilltis virus 2 (BHV2). Vesicle formation, a characteristic feature of early stages of the disease in cow is either absent or occurs rarely in dairy buffaloes. Stress of calving and hormonal changes close to calving are important predisposing factors. The condition is usually sporadic although outbreaks have also been documented. It is more prevalent in buffaloes in their first lactation. Therapeutic interventions be used for the treatment of topical and parenteral administration of antibiotics, topical administration of lysine/propolis, topical and oral administration of acyclovir (An anti-herpes virus drug), oral administration of zinc sulphate and other immunity enhancing agents and parenteral administration of antihistamine, lithium antimony thiomalate and anti-inflammatory drugs. Future research proposals include investigating the oral use of zinc sulphate, local infiltration of acyclovir into the lesions, and the use of an infrared lamp to raise the temperature of the lesion. There is currently no vaccine available. Biosecurity, prevention and proper treatment, insect control, and milking time hygiene are all recommended control and prevention measures.
Surgical Retrieval of Intestinal Metallic Foreign Body in a Pup
Authors: Patel Ushma , Upadhye S. V. , Akhare S. B. , Patond C. V. , Kshirsagar M. , Barde Mayank
Published: August 2022

An eight month old male pomeranian dog was presented at TVCC, Nagpur Veterinary College, Nagpur with a history of frequent vomiting, inappetence and depression since 5 hours. Anamnesis revealed the owners had seen the dog ingesting a thread attached to a needle. On clinical examination the dog was dull, dehydrated with normal body temperature, heart rate and respiratory rate. Lateral abdominal radiograph revealed a radio opaque, linear, sharp, metallic foreign body like a sewing needle in the caudal abdomen . On the basis of history, clinical signs and radiographic findings, the condition was diagnosed as intestinal foreign body. Surgical correction was planned to remove the foreign body. The dog was premedicated with atropine sulphate @ 0.04 mg/kg body weight subcutaneously and xylazine hydrochloride @ 1 mg/kg body weight intramuscularly. General anaesthesia was induced by ketamine hydrochloride @ 10 mg/kg body weight and Diazepam @ 1 mg/kg body weight intravenously and enterotomy was conducted and a sewing needle with thread was removed. The jejunum was sutured with chromic cat gut 3-0 in continuous cushing followed by lembert manner and abdomen was closed in routine manner. Post-operatively administration of antibiotics, analgesics and regular dressing of wound was carried out and the dog recovered uneventfully.
Production of Aureobasidium pullulan by using Sugar Cane Molasses as Economical Media
Authors: Singh Ranjan , Singh Shreyansh , Gaur Rajeev
Published: August 2022

Aureobasidium pullulans, popularly known as black yeast, is one of the most widespread saprophytic fungi associated with wide range of terrestrial and aquatic habitats. The fungus has widely been employed in production of an economically important polysaccharide Pullulan. Pullulan is a linear glucan made mainly of maltotriose repeating units. This gives the polysaccharide structural flexibility and enhances solubility. This polysaccharide is of great economic importance with increase applications in food, pharmaceutical, agriculture, blood plasma substitute and chemical industry. Production of pullulan was observed in a novel media consisting of Sugar Cane Molasses (SCM) and distilled water. It was found that high amount of pullulan (2.5g /100ml) was obtained at 30°C, pH 5 at a concentration of 2.5% media in 96h. No synthetic minerals were used in the media for the growth of polysaccharide making it very economical.
Effect of Tissue Culture in Vegetable Improvement
Authors: Kumar Rahul , Jain Sudhir
Published: August 2022

PAU model farm solar dryer was built and tested for spinach drying at college of technology and engineering, Udaipur. It is discovered that the temperature in the farm solar drier was 41.5 percent higher than the ambient temperature. The farm solar drier needs a total drying duration of 8hours for drying to lower the moisture content.
Analisis tingkat pengangguran terbuka di Indonesia periode sebelum dan saat pandemi covid-19
Authors: Mifrahi Mustika Noor , Darmawan Angga Setyo
Published: August 2022

Abstract
Purpose – This study aims to analyze the Open Unemployment Rate (TPT) in Indonesia during and before the Covid-19 pandemic in terms of HDI, GRDP, minimum wage, and inflation.
Methods – The analytical method used is a paired sample test analysis and panel data analysis for each province in Indonesia from 2010 to 2021.
Findings – The results indicate that there were differences in the value of TPT in Indonesia in the period before and during the Covid-19 pandemic. In addition, the factors that affect the TPT rate in the period 2010-2021 are the growth rate of GRDP, HDI and Covid 19. While the value of the UMP level and inflation have no significant effect on TPT.
Implication – The results of the study recommend that policy makers in dealing with open unemployment in Indonesia focus more on microeconomic factors.
Originality – This research contributes to analyzing the open unemployment rate in Indonesia before and after covid-19
 
Abstrak
Tujuan – Penelitian ini bertujuan untuk menganalisis Tingkat Pengangguran Terbuka (TPT) di Indonesia pada saat dan sebelum adanya pandemi Covid-19 dari sisi IPM, PDRB, UMP, dan inflasi.
Metode – Metode analisis yang digunakan adalah analisis uji beda dan pengujian data panel untuk setiap provinsi di Indonesia dari tahun 2010 hingga 2021.
Temuan – Hasil penelitian menunjukkan bahwa terdapat perbedaan nilai TPT di Indonesia pada periode sebelum dan saat pandemi Covid-19. Selai itu, faktor yang mempengaruhi nilai TPT dalam periode 2010-2021 yaitu laju pertumbuhan PDRB, IPM dan Covid 19. Sedangkan nilai tingkat UMP dan inflasi tidak berpengaruh signifikan pada TPT.
Implikasi – Hasil penelitian merekomendasikan pada pengambil kebijakan dalam menangani penggangguran terbuka di Indonesia lebih menitik beratkan pada faktor-faktor mikroekonomi.
Orisinalitas – Penelitian ini berkontribusi dalam menganalisis tingkat pengangguran terbuka di Indonesia sebelum dan sesudah covid-19
Analisis determinan pertumbuhan ekonomi Provinsi Jawa Tengah
Authors: Rudatin Ari , Indraswari Enggarsani Maulida
Published: August 2022

Abstract
Objectives – This study aims to analyze the effect of regional spending, number of tourist visits, and population on economic growth.
Methods – This study uses a multiple linear regression model with panel data from 2015-2020 in six districts/cities in the Kedu Residency Region.
Findings – The research results show that regional spending has a positive effect on economic growth, and the number of tourist visits positively affects economic growth. The population has no impact on economic growth.
Implications – Analysis of factors that can increase regional economic growth is essential for local governments to boost economic growth. Local governments should know which sectors should be developed more quickly to increase economic growth.
Originality – This study analyzes the effect of regional spending, number of tourist visits, and population on economic growth.
 
Abstrak
Tujuan – Penelitian ini bertujuan menganalisis pengaruh belanja daerah, jumlah kunjungan wisata, dan jumlah penduduk terhadap pertumbuhan ekonomi.
Metode – Penelitian ini menggunakan model regresi linear berganda dengan data panel yang diambil dari tahun 2015-2020 di enam kabupaten/kota di Wilayah Karesidenan Kedu.
Temuan – Hasil dari penelitian yang telah dilakukan menunjukkan bahwa belanja daerah berpengaruh positif terhadap pertumbuhan ekonomi, jumlah kunjungan wisata berpengaruh positif terhadap pertumbuhan ekonomi dan jumlah penduduk tidak berpengaruh terhadap pertumbuhan ekonomi.
Implikasi – Analisis faktor-faktor yang dapat meningkatkan pertumbuhan ekonomi daerah penting dilakukan sebagai acuan pemerintah daerah dalam meningkatkan pertumbuhan ekonomi. Pemerintah daerah sebaiknya mengetahui sektor mana saja yang harus dikembangkan lebih cepat dalam meningkatkan pertumbuhan ekonomi.
Originalitas – Penelitian ini focus untuk menganalisis pengaruh belanja daerah, jumlah kunjungan wisata, dan jumlah penduduk terhadap pertumbuhan ekonomi.
Doing More With Less: Racial Diversity in Nonprofit Leadership and Organizational Resilience
Authors: Mumford Steven
Published: August 2022

Racial diversity in nonprofit leadership presents a variety of benefits crucial for responding to the COVID-19 pandemic. However, leadership remains predominately white. Practitioner-oriented studies decry racial disparities in nonprofit funding, but academic literature offers mixed conclusions on how diversity influences resource acquisition. This article examines associations between racial composition of nonprofit leadership and organizational resilience to the pandemic, based on a survey of New Orleans-based nonprofits in winter 2021. Logistic regressions assess whether leadership diversity increases the likelihood of organizational resilience in both service delivery and financial health, finding that greater board diversity is associated with targeted programming and advocacy to support racially diverse communities, and expanded service delivery. However, greater Black board representation is associated with lack of reserves, threatening financial sustainability. The analysis uncovers disparate effects of racial diversity on resilience for service delivery versus finances, suggesting diverse nonprofits are “doing more with less” in response to the pandemic.
Meanings Matter: The Relationship Between Constitutional Values and Social Justice
Authors: Trochmann Maren B. , Guy Mary E.
Published: August 2022

Social upheavals are punctuation marks in the progression toward social equity. The American democratic mythos has evolved since the first days of the republic. Those who were ‘in the room’ when the Constitution was signed drove the interests that were represented and protected. Those in the room now are different, infusing old words with new meanings. Today’s fissured political culture, combined with the ripple effects of a global pandemic, offer another upheaval and create the opportunity to impel social justice. The ongoing process of meaning-making transforms power and advantage. This essay urges public service professionals to adopt a message that champions the mythos while acknowledging lived reality.
Perioperative Identification and Management of Hyperglycemia in Orthopaedic Surgery
Authors: Lamanna Daniel L. , McDonnell Marie E. , Chen Antonia F. , Gallagher John M.
Published: August 2022

➤ The consequences of undermanaged perioperative hyperglycemia are notable and can have a serious impact on adverse postoperative outcomes, especially surgical site infections and periprosthetic joint infections (PJIs).

➤ Preoperative screening of hemoglobin A1c with a goal threshold of <7.45% is ideal.

➤ There are a variety of risk factors that contribute to hyperglycemia that should be considered in the perioperative period, including glucocorticoid use, nutritional factors, patient-specific factors, anesthesia, and surgery.

➤ There are expected trends in the rise, peak, and fall of postoperative blood glucose levels, and identifying and treating hyperglycemia as swiftly as possible are the fundamental aims of treatment and improved glucose control. Performing frequent postoperative blood glucose monitoring (in the post-anesthesia care unit, on the day of surgery at 1700 and 2100 hours, and in the morning of postoperative day 1) should be considered to allow for the early detection of alterations in glucose metabolism. In addition, instituting a postoperative dietary restriction of carbohydrates should be considered.

➤ The use of insulin as a hypoglycemic agent in orthopaedic patients is relatively safe and is an effective means of controlling fluctuating blood glucose levels. Insulin therapy should be administered to treat hyperglycemia at ≥140 mg/dL when fasting and ≥180 mg/dL postprandially. Insulin therapy should be ceased at blood glucose levels of <110 mg/dL; however, monitoring for glycemic dysregulation should be continued. In all cases of complex diabetes, consultation with diabetes specialty services should be considered.

➤ The emerging use of technology, including continuous subcutaneous insulin pump therapy and continuous glucose monitoring, is an exciting area of further research and development as such technology can more immediately detect and correct aberrations in blood glucose levels.
Improving Lazismu Performance in the Perspective of Modern Philanthropy, Shariah Enterprise Theory, and Comprehensive Intellectual Capital Management
Authors: Hermawan Sigit , Wiwit Hariyanto
Published: August 2022

Lazismu sebagai entitas sosial dan keagamaan haruslah terus berbenah menjadi gerakan filantropi modern yang harus mampu melaporkan kegiatannya baik dalam dimensi habluminnanas dan habluminallah. Lazismu juga harus terus meningkatkan kinerja organisasi dalam rangka menjadi sustainability. Oleh karena itu tujuan penelitian ini adalah untuk merumuskan strategi Lazismu untuk menjadi gerakan filantropi modern, merumusankan pengelolaan ZIS berbasis laporan Shariah Enterprise Theory (SET), dan upaya peningkatan kinerja berbasis Comprehensive Intellectual Capital Management (CICM). Metode penelitian ini dilakukan dengan kualitatif interpretif. Hasil penelitian menyatakan bahwa strategi menjadikan lazismu sebagai gerakan filantropi modern dapat dilakukan dengan pendekatan teknologi informasi, struktur organisasi yang baik, dan manajemen organisasi yang terencana. Untuk pengelolaan dana ZIS berbasis SET dapat dilakukan dengan membuat laporan SET yang terdiri dari empat kontribusi, yakni kontribusi pada Allah SWT, kontribusi pada direct stakeholders, kontribusi pada indirect stakeholders, dan kontribusi alam. Untuk peningkatan kinerja Lazismu berbasis CICM dapat dilakukan dengan optimalisasi tiga komponen IC, yakni human capital, structural capital dan relational capital dengan tahapan knowledge management, innovation management, dan intellectual property management
Low-stakes, VLE intensive, formative approach to maths teaching as a pedagogic strategy for improving assessment outcomes
Authors:   University of Greenwich, Force Susan , Goss-Sampson Mark ,   University of Greenwich, Harris Sarah ,   University of Greenwich
Published: August 2022

Functional numeracy skills in the UK workforce have been an issue for at least 20 years and are of mounting concern due to the increasing use of technology in the workplace and the need for mathematical problem solving skills. Surveys reveal anxiety related to maths (MA) has a negative impact on Higher Education (HE) subject choices and subsequent career options. This at a time when Science, Technology, Engineering and Mathematics (STEM) subjects, requiring maths and data handling skills, are in high demand globally. This case study relates the journey from discovering the need for maths support in science students to the use of low-stakes, VLE intensive, formative maths support as a means of overcoming MA and improving student outcomes.
You did what at the weekend? - A workshop to develop the digital awareness and understanding of digital footprints amongst primary education studies undergraduates
Authors:   Anglia Ruskin University, Parkin John
Published: August 2022

Digital footprints, which are the records left online through the use of social media such as Twitter and Instagram, are a growing concern for the future employability of undergraduates. This case study explores research the co-creation of a workshop about digital footprints with undergraduates on a Primary Education Studies degree in an English university to protect professional identities. The workshop included a range of activities to help undergraduates learn about the importance of digital footprints, how to check their own digital footprints, explore steps to protect their digital identities on different social networks, and how to curate a positive digital identity. It is argued here that undergraduates need more opportunities to learn about digital footprints.
An examination of co-teaching in an online environment
Authors:   University of Greenwich, Pappu Anusha , Bogaars Alistair ,   University of Greenwich
Published: August 2022

Co-teaching, employed as a pedagogical tool, is a teaching method commonly used to improve students’ collaborative learning. It can be defined as two or more professionals delivering substantive instruction to a diverse group of students in a single physical space or as blended delivery. Team teaching is an approach to co-teaching, a Business Education method since the 1990s. This case study examines tutor experience and observations of co-teaching on a level 4 specialist transport and logistics module delivered online in 2020-2021. We are the teaching team for the module at the University of Greenwich and worked as two co-tutors. Using a mixed methods approach, we have compared, across a range of parameters, student outcomes for a) co-teaching and b) teaching by a single person. The quantitative measures included attendance, marks awarded and student satisfaction (EvaSys scores) and the black, Asian and minority ethnic (BAME)/white module gap; the qualitative measures consisted of tutor observations. Across the quantitative measures, the results are consistent with the suggestion that students may have benefited from being co-taught. Similarly, the qualitative measures indicate greater student engagement with co-teaching than with teaching by one person. We feel that the initial findings from our analysis demonstrate that there is potential for further exploration of the benefits that might be gained from a wider application of team teaching across the Business Faculty.
Investigation of Rock Burst Mechanism under Thermomechanical Coupling Conditions Based on Rock Mechanical Tests
Authors: Li Tianbin , Shu Zhile , Zhang Xin , Gao Meiben , Pan Huangsong
Published: August 2022

The thermomechanical (TM) coupling effects of rock bursts have attracted considerable attention from researchers owing to the high geothermal and geostresses in deep tunnels in regions such as Western China. To study the brittleness and rock burst mechanism under TM conditions, various tests, such as splitting, uniaxial compression, rock burst tendency, and rock burst physical model tests, were conducted at temperatures ranging from 20°C to 80°C. The results revealed that, when granite samples were heated, their tensile strengths decreased in the splitting tests. Their peak stresses and the corresponding strains increased; their macroscopic tensile fracture surfaces became more evident; and the microcosmic tensile properties of intergranular fractures became prominent under uniaxial compression. Rock burst physical model tests and acoustic emission monitoring results revealed that, at higher temperatures, the fracture degree and failure range were larger, the energy was higher and more concentrated during failure, and failure occurred earlier. The brittleness index B, rock burst tendency Wet, and σθ/σc all exhibited a clear increasing tendency with an increase in temperature. The rock burst mechanism, considering the temperature effect, can be summarized as follows: the increase in brittle tensile fracture components and geostress caused by temperature increasing is conducive to the rapid release of energy, which will promote the occurrence of rock burst. The researching result is of great academic value and practical significance for the prevention, design, and safe construction of rock burst in deep high geothermal tunnels.
ConsensusPrime - a bioinformatic pipeline for alignment filtering and ideal consensus primer design
Authors: Collatz Maximilian , Braun Sascha D. , Monecke Stefan , Ehricht Ralf
Published: August 2022

High quality oligonucleotides for molecular amplification and detection procedures of diverse target sequences depend on sequence homology. The processing of input sequences and the identification of homogeneous regions in alignments can be done manually only if alignments are small and if they contain sequences of high similarity. For large and inhomogeneous alignments, the process of finding the best regions needs to be automated.The ConsensusPrime pipeline was developed sort out redundant and technical interfering data in multiple sequence alignments and detect the most homolog regions from multiple sequences. It automates the prediction of optimal consensus primers for molecular analytical and sequence-based procedures/assays.ConsensusPrime is a fast and easy to use pipeline for predicting optimal consensus primers that is executable on local systems without depending on external resources and webservices. An implementation in a Docker image ensures platform-independent executability and installability despite the combination of multiple programs. The source code and installation instructions are publicly available on GitHub (https://github.com/mcollatz/ConsensusPrime).
Evaluating the harmonisation potential of diverse cohort datasets
Authors: Bauermeister Sarah , Phatak Mukta , Sparks Kelly , Sargent Lana , Grizwold Michael , McHugh Caitlin , Nalls Mike , Young Simon , Bauermeister Joshua , Elliot Paul , Steptoe Andrew , Porteous David , Dufouil Carole , Gallacher John
Published: August 2022

Background
Data discovery, the ability to find datasets relevant to an analysis, increases scientific opportunity, improves rigour and accelerates activity. Rapid growth in the depth, breadth, quantity and availability of data provides unprecedented opportunities and challenges for data discovery. A potential tool for increasing the efficiency of data discovery, particularly across multiple datasets is data harmonisation.
Methods
A set of 124 variables, identified as being of broad interest to neurodegeneration, were harmonised using the C-Surv data model. Harmonisation strategies used were simple calibration, algorithmic transformation and standardisation to the Z-distribution. Widely used data conventions, optimised for inclusiveness rather than aetiological precision, were used as harmonisation rules. The harmonisation scheme was applied to data from four diverse population cohorts.
Results
Of the 120 variables that were found in the datasets, correspondence between the harmonised data schema and cohort-specific data models was complete or close for 111 (93%). For the remainder, harmonisation was possible with a marginal a loss of granularity.
Conclusions
Although harmonisation is not an exact science, sufficient comparability across datasets was achieved to enable data discovery with relatively little loss of informativeness. This provides a basis for further work extending harmonisation to a larger variable list, applying the harmonisation to further datasets, and incentivising the development of data discovery tools.
Association of Clinical, Laboratory and Ultrasound Characteristics With the Etiology of Peripheral Lymphadenopathy in Children
Authors: Berce Vojko , Brodnik Aleksandra Zorko , Dorič Maja , Rataj Nina , Kolarič Tjaša
Published: August 2022

Background: Peripheral lymphadenopathy affects most children at least once in a lifetime and represents a major reason for concern for children and their caregivers, although the malignancy is an uncommon cause of lymphadenopathy in this age group. Viral infections such as infectious mononucleosis is a common cause of bilateral cervical lymphadenitis or generalized lymphadenopathy in older children. Pyogenic bacteria and granulomatous diseases usually cause unilateral lymph node enlargement. We aimed to identify the most common causes of peripheral lymphadenopathy in hospitalized children and to determine the clinical, laboratory and ultrasound characteristics that enable easy and accurate etiological diagnosis.Methods: We performed a cross-sectional study including 139 children who were hospitalized because of peripheral lymphadenopathy and in whom the etiological diagnosis could be ascertained. Blood tests, including serology for Epstein-Barr virus and Bartonella hensleae were performed in all children, and ultrasound of lymph nodes was performed in 113 (81.3%) of them. Incision with the detection of bacteria, aspiration biopsy or extirpation of lymph nodes were performed when clinically indicated. The Mann-Whiney U test or chi-squared test and a (multinomial) regression analysis was performed to compare epidemiological, clinical, laboratory and ultrasound characteristics of patients with three most common etiologies.Results: Lymphadenopathy was generalized in 9 (6.5%) patients. 114 (82.0%), 6 (4.6%), 6 (4.6%) and 4 (3.1%) patients presented with localized lymphadenopathy in the cervical, axillary, supraclavicular and inguinofemoral areas, respectively. Malignant etiology was established in only 3 (2.2%) patients. Bacterial lymphadenitis, infectious mononucleosis (IM) and cat scratch disease (CSD) was diagnosed in 66 (47.5%), 31 (22.3%) and 29 (20.9%) patients, respectively. Bacterial lymphadenitis was significantly associated with neutrophilia (p<0.01) and increased C-reactive protein levels (p<0.01). IM was associated with pharyngitis (p<0.01), leukocytosis without neutrophilia (p=0.03), increased blood liver enzyme levels (p<0.01) and lactate dehydrogenase levels (p<0.01). CSD was associated with recent contact with a cat (p<0.01), absence of a fever (p<0.01) and normal white blood cell count (p<0.01).Conclusions: Thorough history and clinical examination in combination with a few basic laboratory tests enable fast and accurate differentiation between the most common etiologies of lymphadenopathy in children to avoid unnecessary procedures and hospitalizations.
Persistent symmetrical bilateral hypertension on DWI in a patient with Hashimoto's thyroiditis: a Case Report
Authors: Zhu Shu-lai , Pan Xin-xin , Peng Yu-hua
Published: August 2022

We report a case diagnosed metabolic encephalopathy following Hashimoto's thyroiditis whose MRI shown persistent symmetrical bilateral hypertension on DWI in the past two years. To our knowledge this is the first report of persistent symmetrical bilateral hypertension on DWI in a patient with Hashimoto's thyroiditis.
Comparison of weight-bearing full-length radiography and three-dimensional computed tomography scan-based models for the assessment of knee joint coronal alignment following total knee arthroplasty
Authors: Kato Michitaka , Warashina Hideki , Kataoka Akito , Mitamura Shingo
Published: August 2022

Purpose: We evaluated measurement reliability and validity of long-leg radiography (LLR) after total knee arthroplasty (TKA) by comparing postoperative three-dimensional computed tomography (3DCT) scans of the lower extremities.Methods: We retrospectively collected data from 55 knees that underwent postoperative 3DCT, 5-day and 6-month LLR for coronal alignment after TKA. Coronal femoral component angle (CFA) and coronal tibial component angle (CTA) were measured with postoperative 3DCT, 5-day and 6-month LLR. The correlations between the hip–knee–ankle angle (HKAA), CFA, and CTA measured using 3DCT scans and radiographs (5-day and 6-month LLR) were analysed using Pearson’s correlation coefficient (PCC). Bland-Altman plots were constructed to assess agreement between 5-day and 6-month LLR and3DCT scan measurements.Results: The mean difference in the HKAA between 3DCT and 5-day and 6-month LLR was 1.3°±1° and 1.1°±0.7°, respectively. Differences of >1° in the HKAA between 3DCT and LLR were observed in 31 (56.4%) and 28 (50.9%) knees during 5-day and 6-month LLR, respectively. Differences of >2° in these parameters were observed in 15 (27.3%) and 9 (16.4%) knees during 5-day and 6-month LLR, respectively. However, 3DCT scan and LLR measurements showed a strong correlation (PCC, 0.81–0.92; P < 0.000) for all HKAA, CFA, and CTA, and the validity of the Bland-Altman plot was within acceptable limits.Conclusion: Coronal alignment measurement using LLR yielded good reliability and validity. However more than half of the HKA angle values measured by 3DCT scan and radiographs differed by more than 1°, and approximately 20% differed by more than 2°.Level of Evidence: Level IV
Exploring Deaf/Hard of Hearing students reading strategies utilization
Authors: Hailemariam Bereket , Barkesa Mendida
Published: August 2022

The general objective of this study was to assess reading comprehension strategies utilization of deaf students of Mekane Eyesus School for the Deaf. Accordingly, it assessed reading comprehension strategies use of each of grades 5–12 deaf students and determined the overall reading comprehension strategies use of the participant deaf students. A case study research design was chosen. Twenty one grade 5–12 deaf students were selected randomly for the study. The data were collected through Cognitive Awareness of Reading Strategies Inventory (CARSI; Mokhtari & Reichard, 2002). The data from the questionnaire were analyzed using descriptive statistics in SPSS Version 21. The results revealed that medium level global reading strategies subscale use mean (M = 3.26, SD = .69) with the majority of the sample 10 (47.6%) reporting medium level use of Global Strategies use. On the other hand, problem-solving strategies use subscale mean was (M = 3.67, SD = .69) with the majority of the sample 15 (71.4%), reported high level use of Problem solving strategies and Support strategies use subscale mean was (M = 3.6, SD = .81), with more than half of the sample, 13 (61.9%), reported high level use of Support strategies use. However, the Overall strategies use mean was (M = 3.47, SD = .61), with the majority of the sample 11 (52.4%), reported medium level use. As a result, the problem solving reading approach appeared to be used more frequently than the other strategy types in this study and the Overall strategies use revealed medium level use.
Induction TPF followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locally advanced hypopharyngeal cancer: a preliminary result of a randomized phase 2 trial
Authors: Luo Xi , Huang Xiaodong , Liu Shaoyan , Wang Xiaolei , He Xiaohui , Luo Dehong , Luo Jingwei , Xiao Jianping , Wang Kai , Qu Yuan , Chen Xuesong , Zhang Ye , Wu Runye , Wang Jingbo , Zhang Jianghu , Xu Guozhen , Gao Li , Yi Junlin
Published: August 2022

Purpose
Concurrent chemoradiotherapy (CCRT) was one of the standard treatment choices for locally advanced hypopharyngeal carcinoma. The aim of this study was to investigate whether IC followed by CCRT is superior to CCRT in locally advanced hypopharyngeal carcinoma.
Methods and Materials:
142 patients were randomized to receive two cycles of docetaxal /cisplatin/5-fluorouracil (TPF) IC followed by CCRT or CCRT alone. The primary end point was overall survival (OS). Secondary end points included larynx-preservation rate, progression-free survival (PFS), distant metastasis-free survival (DMFS) and toxicities.
Results
113 of 142 patients were finally analyzed. With a median follow-up of 45.6 months (IQR 26.8–57.8), the 3-year OS was 53.1% in the IC + CCRT compared with 54.8% in the CCRT (HR, 1.004; 95% CI, 0.573 to 1.761; P = 0.988). There were no statistically significant differences in PFS, DMFS and larynx-preservation rate between the two groups. Grade 3–4 hematological toxicity incidence was much higher in the IC + CCRT group than that in the CCRT group (54.7% vs 10%, P < 0.001).
Conclusions
Adding induction TPF to CCRT could not improve the survival and larynx-preservation rate in locally advanced hypopharyngeal cancer but in the cost of higher acute hematological toxicities.
Vascular Characteristics and Prognosis of Gestational Trophoblastic Neoplasia with Uterine Arteriovenous Malformation
Authors: Zhou Qing , Liu Yuantao , Lu Xin , Zhang He , Ma Fenghua , Zhang Guofu
Published: August 2022

Objective: To investigate vascular characteristics and prognosis of gestational trophoblastic neoplasia (GTN) with uterine arteriovenous malformation(UAVM) Methods: Forty-four patients with GTN at our hospital from December 2015 to December 2020 were selected. Imaging characteristics of MRI and CE-MRA before treatment, treatment methods, and the prognosis were followed-up. Results: A total of 44 cases were included, including five cases of placental site trophoblastic tumor (PSTT) and 39 cases of the other GTN. There were two cases of PSTT combined with UAVM and 23 cases of the other GTN combined with UAVM. Thirty-nine cases of the other GTN were divided into two groups according to the presence or absence of UAVM. Data regarding the β-human chorionic gonadotropin value (<10,000 mIU/mL and ≥10,000 mIU/mL) were evaluated using Chi-square test (P = 0.001); the difference was statistically significant (P < 0.05). The average FIGO scores of the two groups were 4.19 (±3.69) and 6. 70 (±3.39) (P = 0.035); the difference was statistically significant (P < 0.05). Vascular characteristics of all the patients were analyzed.Conclusion: Most of the lesions are supplied by uterine arteries and drained by uterine veins and ovarian veins. When β-hCG is ≥10,000 mIU/mL, the probability of UAVM increased. The higher the prognosis score, the greater the possibility of UAVM.
Cytotoxic assessment of 3D printed photoinitiated prosthodontic resins versus heat polymerized acrylic resin (In-Vitro Study)
Authors: Farid Maisa , Mohamed Faten , Mehanna Radwa , Abd-ELLAH Mervat , Abdelrahman Hams
Published: August 2022

Background: Although 3D printed photoinitiated resins are among the many materials utilized in prosthetic appliances today, biocompatibility for photocuring 3D printing materials for direct and long-term contacting with living body remain scarce. The purpose of this in vitro study was to evaluate the cell viability of human gingival fibroblasts after the exposure to two different 3D printed photoinitiated resins and compare it to the traditionally used heat polymerized acrylic resin for up to 7 days.Methods: This comparative in vitro study of sample size (n= 96), where the 3D printed resin disc samples (n= 64), were divided into two test groups, test group 1 (TG1) for NextDent Base resin (n= 32) and test group 2 (TG2) for Dental LT clear resin (n= 32), to be compared to Heat polymerized acrylic resin samples (Reference group (RG)) (n= 32). Human gingival fibroblasts were extracted from attached keratinized gingival tissues collected from healthy patient undergoing clinical crown lengthening procedure, cellular viability using MTT assay in response to TG1, TG2 and RG samples was assessed throughout four-time intervals (24, 48, 72 and 168 hours). The One-Way ANOVA test followed by Tukey’s post hoc test and Repeated Measures ANOVA test were used for statistical analyses, statistically significant different at P value ≤ 0.05Results: Throughout time intervals, there was a decrease in cell viability of all groups but with favorable cell viability which was more that 90% denoting non cytotoxicity. It was found to be significant among RG (P< 0.0001). The highest cell viability was found after 24 hours among all groups; however, the least viability was found after 48 hours among TG1 and RG, and among TG2 after 72 hours. After 168 hours, there was a non-statistical significant change in cell viability between groups (P= 0.526). there was significant increase in optical density for all groups throughout time intervals (P< 0.0001).Conclusion: Photoinitiated resins are comparable to traditionally used heat polymerized acrylic resin with equivalent cytotoxic effect for long term use. 3D printed photoinitiated resins are biocompatible and suggested for long term intraoral use.
Replicative Bypass Studies of L- deoxyribonucleosides in Vitro and in E. coli cell
Authors: Kan Yuhe , Jin Zhaoyang , Ke Yongqi , Lin Dao , Yan Liang , Wu Li , He Yujian
Published: August 2022

l-nucleosides were the most important antiviral lead compounds because they can inhibit viral DNA polymerase and DNA synthesis of many viruses, whereas they may lead to mutations in DNA replication and cause genomic instability. In this study, we reported the replicative bypass of l-deoxynucleosides in recombinant DNA by restriction enzyme–mediated assays to examine their impact on DNA replication in vitro and in E. coli cells. The results showed that a template l-dC inhibited Taq DNA polymerase reaction, whereas it can be bypassed by Vent (exo−) DNA polymerase as well as in cell replication, inserting correct nucleotides opposite l-dC. l-dG can be bypassed by Taq DNA polymerase and in E. coli cells, maintaining insertion of correct incoming nucleotides, and l-dG induced mutagenic replication by Vent (exo−) DNA polymerase. In contrast, l-dA can induced mutagenic replication in vitro and in E. coli cells. MD simulations were performed to investigate how DNA polymerase affected replicative bypass and mutations when D-nucleosides replaced with l-nucleosides. This study will provide a basis for the ability to assess the cytotoxic and mutagenic properties of the l-nucleoside drugs.
Development of an Indicator of Collaborative Practice and Clinical Judgment Competency for Oncology Nurses in Japan: A Modified Delphi Method
Authors: Majima Tomoko , Matsudo Madoka , Kunitake Yukari , Umeda Megumi , Kusunoki Junko , Watanabe Miwa , Masujima Mariko , Otsuka Tomoko , Nagasaka Ikuyo , Okamoto Akemi
Published: August 2022

Purpose
This study aimed to develop Collaborative Practice and Clinical Judgment Competency (CPCJC) for oncology nurses and reach a consensus on the validity, importance, and feasibility of an indicator of CPCJC for certified nurse specialists in cancer nursing and graduate students.
Methods
The indicator of CPCJC for oncology nurses enables nurses to identify the challenges faced by patients in cancer wards and their families. This indicator contains 39 items in 13 categories, which correspond to the elements of Tanner’s Model of Clinical Judgment. A two-round modified Delphi study was completed by Japanese certified nurse specialists and graduate students in the Graduate School of Nursing. The first indicator was created by performing a content analysis using case studies and focus group interviews. Panels evaluated the validity, importance, and feasibility of 39 items in 13 categories in Round 1 (R1) and Round 2 (R2) using a 4-level Likert-type scale.
Results
The total number of participants was 46 in R1 and 35 in R2. The Scale-Content Validity Index/Ave values in R1 were 0.98, 0.99, and 0.94 for validity, importance, and feasibility, respectively.
Conclusion
This structured indicator will enable nurses with short clinical experience to collaborate with multidisciplinary teams and provide patient-centered care. This indicator can be used as a consultation tool for nurses belonging to the palliative care team or advanced practice nurses in the oncology team.