bluuebunny/crossref_metadata_2025 huggingface dataset:
Texto e imagen en La cólera de Javier Olivares y Santiago García, o por qué la Ilíada sigue teniendo algo que decirnos
Authors: Unceta Gómez Luis
Published: December 2022

Este trabajo propone un análisis de la novela gráfica La cólera (2020) de Javier Olivares y Santiago García, en el que, desde la perspectiva de la Recepción Clásica, se atiende a las novedades que propone esta reescritura de la Ilíada. Esas novedades son especialmente llamativas en dos ámbitos: la identidad de género y sexual, y las desigualdades sociales. A través de la feminización del personaje de Aquiles que propone la obra, se aborda, por una parte, un cuestionamiento de los papeles de género tradicionales, la fluidez entre ambos y la problemática de la orientación sexual y, por otra, una denuncia de la injusticia social, que no solo afecta al género, sino también a otros parámetros sociales, como los factores económicos. El trabajo, por último, ilustra las ventajas que ofrece el análisis de obras recientes desde el punto de vista de la Recepción Clásica.
Enfoques, prácticas recomendadas, modelos y procedimientos en atención temprana centrados en la familia
Authors: García-Grau Pau , Morales-Murillo Catalina P. , Martínez-Rico Gabriel , Cañadas Pérez Margarita , Escorcia Mora Claudia Tatiana
Published: December 2022

La evidencia científica en atención temprana (AT) ha demostrado que un enfoque centrado en la familia, en el aprendizaje, la funcionalidad y la participación social, tiene un impacto positivo en el niño, en el entorno y en la propia familia. Este cambio de visión, se propone como un marco de referencia en los servicios. Durante la última década, tanto en España como en otros países, los servicios están transformando sus programas hacia un enfoque centrado en la familia y en la intervención en las actividades de la vida diaria. No obstante, muchos de los principios que sustentan estas prácticas recomendadas (PR) requieren un proceso de adquisición de habilidades y competencias por parte de los profesionales y de adecuación institucional. Además, el carácter filosófico de los principios de las PR, puede generar confusión y dar pie a una implementación con escasa consistencia interna. Este artículo ofrece una aclaración conceptual útil y una síntesis para profesionales e investigadores del campo de la AT necesaria para comprender las bases y fundamentos que motivan este proceso de transformación de los servicios.
Ansiedad y trastornos del espectro del autismo: notas para la intervención psicoeducativa
Authors: Sánchez-Cueva María Sarah , Alcantud Marín Francisco , Alonso-Esteban Yurena
Published: December 2022

Se analizan de forma narrativa las relaciones entre comportamiento sensorial atípico, intolerancia a la incertidumbre y regulación emocional como generadores de los trastornos de ansiedad en niños y niñas autistas. El objetivo es estudiar el origen de la ansiedad en los niños y niñas autistas con la finalidad de determinar cuál o cuáles pueden ser los procedimientos de intervención más adecuados. Se han revisado algunos de los programas de intervención cognitivo-conductuales más utilizados en niños y niñas autistas y las adaptaciones realizadas a los mismos. Se observa un divorcio entre los programas psicoeducativos escolares y los programas clínicos de intervención para el tratamiento de la ansiedad. Como conclusión, se recomienda que en los programas psicoeducativos escolares se incorporen acciones proactivas en forma de programas de intervención cognitivo-conductuales para evitar o aminorar los efectos negativos de la ansiedad en el aprendizaje e inclusión escolar de los niños y las niñas autistas.
Transpapillary Stenting Improves Treatment Outcomes in Patients Undergoing Endoscopic Transmural Drainage of Ductal Disruption-Associated Pancreatic Fluid Collections
Authors: Ni Jianbo , Peng Kui , Yu Lanting , Xie Haoran , Luo Shengzheng , Xu Kai , Xia Youchen , Xie Ni , Lu Jiawei , Lu Lungen , Hu Duanmin , Wan Xinjian , Li Baiwen
Published: December 2022

INTRODUCTION:

Endoscopic transmural drainage (TMD) has been accepted as the preferred therapy for symptomatic pancreatic fluid collections (PFCs). Recurrence of PFCs presents a unique challenge in patients with disrupted pancreatic duct (PD). We aimed to evaluate whether transpapillary drainage (TPD) provides additional benefits to TMD in patients with PD disruption.

METHODS:

This was a multicenter retrospective study. Consecutive patients who underwent TMD, TPD, or combined drainage (CD) of PFCs were included. The primary outcome was to compare PFC recurrence among different groups. The secondary outcomes were the technical success rate, length of hospital stay, and procedure-related complications.

RESULTS:

A total of 153 patients, which consists of 57 patients with pancreatic pseudocysts and 96 patients with walled-off necrosis, were included. PFC recurrence was more common in patients with PD disruption than those with an intact main duct (19% vs 1.4%, P < 0.001). PD disruption was identified as a major risk factor of PFC recurrence by univariable and multivariable analyses. The recurrence rate of CD was significantly lower than TMD only or TPD only (6.5% vs 15.4% vs 22.7%, P < 0.01). The length of hospital stay of CD was significantly shorter than TMD only or TPD only (5 [3.0–9.0] vs 7.0 [5.0–12.0] vs 9 [7.0–16.0], P < 0.001). Dual-modality drainage did not increase procedure-related complications compared with TMD only (13.0% vs 12.8%, P > 0.05). Partial PD disruption was bridged in 87.3% cases while complete PD disruption was reconnected in 55.2% cases. Although statistically not significant, the clinical success rate in walled-off necrosis cases with actively bridged ducts was much higher than those with passively bridged ducts (76.9% vs 40%).

DISCUSSION:

Transpapillary pancreatic duct stenting seems to improve the efficacy of endoscopic TMD of pancreatic duct disruption-associated PFCs by reducing the recurrence rate and shortening the length of hospital stay.
DESIGN OF ECG SYSTEM FOR REMOTE DATA COLLECTION
Authors: Babušiak Branko , Šmondrk Maroš , Janoušek Ladislav
Published: December 2022

The article introduces the remote ECG data collecting system. The system consists of a one-lead ECG device connectable via USB to a smartphone, an Android application, a server, and a web application. The ECG device is designed as a USB dongle with small dimensions and uses On-the-Go (OTG) powering technique. These features classify the developed device as wearables. The measured ECG data are stored in the smartphone's internal memory and transmitted to the remote biobank server at predefined time intervals for archiving and subsequent processing. The functionality of Android and the web application are also described in the article. Both applications have a user-friendly graphical user interface. The proposed system was tested in two scenarios: ECG measured on the patient simulator and living subject. The measured raw ECG signals are suitable for basic diagnostics of cardiac health and confirmed the correct function of the proposed system.
LONGHINI, Marcos Daniel (Org.). Educação em astronomia: experiências e contribuições para a práti ca pedagógica. Campinas, SP: Editora Ãtomo, 2010./ LONGHINI, Marcos Daniel (Org.). Education in astronomy: experiences and contributioins to pedagogical
Authors: Bretones Paulo Sergio
Published: December 2022

practices. Campinas, SP: Editora Ãtomo, 2010.
Resolution of the consensus of the Russian Federation experts on the diagnosis and treatment of osteoarthritis, 2022
Authors: Lila A. M. , Mazurov V. I. , Martynov A. I. , Zagorodny N. V. , Alekseeva L. I. , Chichasova N. V. , Karateev A. E. , Naumov A. V. , Zonova E. V. , Rachin A. P. , Taskina E. A.
Published: December 2022

Osteoarthritis (OA) is the most common joint disease due to the increasing life expectancy of the world's population. Every 2nd patient over the age of 50 suffers from knee or hip OA, and this is directly related to the increased burden on healthcare. Accumulated data on the comorbid profile of patients with OA dictate the need to identify disease phenotypes in order to provide personalized care. Individual clinical manifestations of OA also require a differential approach: the pain treatment requires consideration of the patient's psycho-emotional profile and the possibility of involving nociceptive pathways in the process. However, due to the ambiguity of existing clinical guidelines, most experts note a number of difficulties in prescribing treatment for patients with OA.

The resolution presents an agreed opinion of experts on the algorithms for managing patients with OA, starting from the primary level, with the gradual involvement of related specialists. Some issues of a personalized approach are considered depending on the presence of comorbid pathology and the severity of individual symptoms of the disease. The prospects of the combined use of pharmacological and non-drug methods of treatment are noted; emphasis was placed on the importance of rehabilitation measures at the first level of medical care, provided to patients with OA, long before the development of structural changes.

The proposed algorithms for managing patients can be considered as the basis for future recommendations for managing patients with this pathology.
Immunoinflammatory rheumatic diseases: the role of the perception of the disease and coping with it in the psychological adaptation of the patient
Authors: Abrosimov I. N. , Yaltonsky V. M. , Sirota N. A. , Lisitsyna T. A. , Yaltonskaya A. V. , Lila A. M.
Published: December 2022

Objective: to analyze the subjective perception of the disease, coping behavior and adherence to treatment as parameters of psychological adaptation of patients with immunoinflammatory rheumatic diseases (IIRD).

Patients and methods. 163 women with IIRD who were on inpatient treatment were examined: 63 with systemic lupus erythematosus, 50 with rheumatoid arthritis, and 50 with systemic scleroderma. The mean age of the patients was 34.00±17.46 years.

Results and discussion. Groups of patients with different types of perception of the disease were identified: "Unformed perception of the disease" (group 1), "Positive perception of disease control" (group 2), "Negative perception of disease threat" (group 3). When comparing the three groups, it was found that in the group with an unformed perception of the disease, negative emotional experiences were less pronounced than in the other two groups. At the same time, the coping strategies "Self-control" and "Problem solving planning" were significantly higher in the group of patients who positively perceived the control of their disease.

Conclusion. Psychological adaptation of patients with IIRD depends on the type of perception of the disease. The identification of two basic profiles (“Disease threat perception” and “Disease and treatment control perception”) and three types of disease perception (“Unformed type of disease perception”, “Positive perception of disease control”, “Negative perception of the disease threat”) made it possible to obtain new, more differentiated ideas about the perception of the disease, which is the target of correctional psychological work with patients suffering from IIRD.
Bone metabolism markers in patients with systemic sclerosis
Authors: Ivanova Yu. Yu. , Bugrova O. V. , Nagornova K. A. , Sayfutdinov R. I.
Published: December 2022

The mechanism of osteoporosis (OP) development in systemic sclerosis (SSc) remains unclear.

Objective: to assess bone mineral density (BMD) and the level of bone metabolism markers (osteocalcin — OC, — C-terminal type I collagen telopeptides — b-CrossLaps) in the blood serum of patients with SSc.

Patients and methods. 65 patients with SSc were examined, 6 (9%) men and 59 (91%) women, the average age was 51 [39; 61] year (main group), and 35 healthy individuals comparable in anthropometric parameters (control group). In all individuals were assessed the most important populational risk factors for OP. BMD was determined using dual energy X-ray absorptiometry (DXA); the level of vitamin D, OC and b-CrossLaps in blood serum — by enzyme immunoassay.

Results and discussion. A decrease in BMD was statistically significantly more common in patients with SSc (46, 71%), than in controls (11, 31%). Significant risk factors for OP in SSc were early menopause, low physical activity, hypovitaminosis D, and probably high activity and duration of the disease. In patients with SSc, there was a significant decrease in the level of OC compared with the controls; in patients with a reduced BMD, the content of OC was significantly less than in patients with normal BMD. The average values of b-CrossLaps in the main and control groups were comparable, but in patients with OP this parameter was lower than in those with normal BMD.

Conclusion. In patients with SSc, OP develops statistically significantly more often than in healthy individuals. Risk factors for OP are early menopause, low physical activity, long duration and high activity of SSc. The predominance of bone formation impairment over bone resorption as a mechanism for the development of secondary OP was noted.
Post hoc analysis of the results of KOLIBRI comparative observational clinical study in patients with knee and small hand joints osteoarthritis
Authors: Feklistov A. Yu. , Vorobieva L. D. , Alekseeva O. G. , Sukhinina A. V. , Andrianova I. A. , Menshikova I. V. , Sorotskaya V. N. , Zotkin E. G.
Published: December 2022

Objective: to evaluate the effectiveness of therapy with AMBENE®Bio (AB) in comparison with the comparator drug (bioactive concentrate of small marine fish, BCSMF) in patients with osteoarthritis (OA) of large and small joints in routine clinical practice.

Patients and methods. KOLIBRI multicenter, observational, non-randomized, comparative study included 233 patients with OA of the small hand joints (HJ) or knee joints (KJ) from three Russian centers (two in Moscow and one in Tula). Patients with a generalized form of OA were excluded from the analysis. The remaining patients were divided into two groups depending on the localization of OA. The first group included 174 patients with knee OA, 105 of them received AB, and 69 received the reference drug (BCSMF) according to the same regimen. The second group consisted of 21 women with HJ OA: 13 patients were prescribed AB, and 8 — the reference drug.

The duration of the study averaged 330±14 days, the total number of visits was 4. The main indicator of effectiveness was the dynamics of pain during movement according to VAS (0—100 mm) 30±7 days after the start of treatment compared with the baseline value. All patients underwent radiography of the HJ and KJ, as well as ultrasound of the involved joints.

Results and discussion. Both drugs provided significant clinical improvement in patients with OA, which is consistent with other studies with similar design and long follow-up. These data confirm the symptom-modifying properties of the presented group of combined drugs in the OA treatment. The Russian injectable drug AB in OA was not inferior in effectiveness to the foreign BCSMF. According to the OMERACT-OARSI criteria, 85.2% and 88.9% of patients, respectively, responded to treatment with AB and the reference drug. In both groups, half of the patients managed to stop further use of non-steroidal anti-inflammatory drugs (NSAIDs) on a regular basis.

Conclusion. The use of AB was accompanied not only by a decrease in the severity of clinical symptoms of OA, but also by a decrease in the daily requirement for NSAIDs almost by 2 times.
Transformed diffuse large B-cell lymphoma of the stomach in a patient with Sjögren's disease and systemic sclerosis: case report and literature review
Authors: Vasiliev V. I. , Gorodetskiy V. R. , Chaltsev B. D. , Probatova N. A. , Shornikova N. S. , Kokosadze N. V. , Pavlovskaya A. I. , Borisenko E. A. , Gaiduk I. V.
Published: December 2022

This article describes a case of a transformed diffuse large B-cell lymphoma of the stomach in a patient with Sjögren's disease (SjD) and systemic sclerosis (SSc), as well as a brief review of the literature on lymphoproliferative diseases in SjD and SSc.
La retirada española de Irak (2004) y la conciencia de defensa
Authors: Gallego Aranda Francisco José
Published: December 2022

La conciencia de defensa nacional es un elemento clave en la defensa de un Estado. En España, todos los gobiernos han considerado un objetivo prioritario fortalecerla. En el periodo 2001-2007, la Defensa y las Fuerzas Armadas alcanzaron niveles máximos de notoriedad y presencia mediática mientras surgían los conflictos de Irak y Afganistán, donde se desplegaban contingentes internacionales que provocaron que algunos sectores de la opinión pública los vieran como conflictos neocoloniales. Esta visión ha dificultado verlos desde otras perspectivas y provocado rechazo en la opinión pública. La retirada del contingente español en Irak, tras un atentado terrorista, tuvo un impacto significativo en la conciencia de Defensa.
Scholars and Literati at the Academy of Sciences, Letters, and Arts of Clermont-Ferrand (1747-1793)
Authors: De la Croix David , Delvaux Elise
Published: December 2022

This note summarizes our research into the group of scholars and literati who were at the Academy of Sciences, Letters, and Arts of Clermont-Ferrand, or connected to it, from its early meetings to its dissolution.
Comparing Etymological Characteristics of Plant Naming in Yakut, Even, and Evenk Languages
Authors: Osorova Marina A. , Malysheva Ninel V. , Timofeeva Ayta V.
Published: December 2022

This article considers issues of language contacts between Yakut, Even, and Evenk people through an analysis of plant vocabulary. We define etymological characteristics of fixed lexical units that denote plant names and present results of a comparative analysis of plant naming in these three languages, with emphasis on lexical parallels and structural types in designating plant names. To our knowledge, this is the first research to undertake a comparative study of plant naming in the Yakut and Tungusic languages (Even and Evenk) with consideration of the methods of their formation. The study is highly relevant because of the unique contribution of plant-world vocabulary in helping to clarify peculiarities of native speakers’ natural environments. Our results show that, based on lexical units with stable semantic meaning, the Evenk language is in the closest position vis-à-vis Yakut. There are 16 names in Yakut of plants and four of common names of herbs that grow on the territory of the Republic of Sakha (Yakutia) and have borrowed names in Evenk and Even. Twenty-eight names have lexical parallels in Evenk (including variations) and two in Even.
Za Adelaidou Reyesovou (1930–2021)
Authors: Jurková Zuzana
Published: December 2022

24. srpna 2021 zemřela ve svém bytě s úchvatným výhledem přes řeku Hudson na newyorský Manhattan významná etnomuzikoložka Adelaida Reyesová. Bylo jí 91 let. Protože měla blízko k Praze i specificky k Fakultě humanitních studií UK, je na místě si ji připomenout.
Women politicians in Austria: Still not breaking the media ceiling
Authors: Hayek Lore , Mayrl Manuel , Russmann Uta
Published: December 2022

The underrepresentation of women politicians in the media is a persistent feature in many contemporary democracies. Gender bias in election coverage makes it harder for women to reach positions of power in politics. Drawing on the special circumstances in Austria during the 2019 election campaign which saw the first female top candidate of a major party and a caretaker government containing equal numbers of men and women and which was led by the country’s first woman as chancellor, we examine the effect of these developments on women politicians’ representation in campaign coverage. We draw on quantitative content analysis of Austrian newspaper articles (N = 16,125) during four national parliamentary election campaigns (2008, 2013, 2017 and 2019). We show that for women politicians the media ceiling is slowly lifting at best, but that positions of power provide the most promising ways to evade gendered media bias.
Simulation of ultra long reach and high speed date rate optical wireless multiplexing communication systems based on various modulation codes
Authors: Rashed Ahmed Nabih Zaki , Altahan Baraa Riyadh , Manasavenna Thaticharla , Priya P. Poorna , Krishna M. Rama , Ahammad S. K. Hasane , Hossain Md. Amzad , Zidan Walid Fahim
Published: December 2022

This article has clarified ultralong reach and high data rate optical wireless multiplexing communication systems based on various modulation codes. Optical wireless communications can provide communication at high speed and achieve farther long distance compared to RF links. It is assured that the low bit rates can be used for long distance error-free transmission. The Q-factor decreases as the distance increases. The error at the receiving station increases with increase in transmission distance. Higher antenna aperture can achieve long distance transmission. The simulation results presented ultralong reach high speed date rates by utilizing VCSEL light sources and APD receivers. The optical signals with low bit rates can be used for long transmission reach. The performance of OWC link can be improved by using VCSELs and APDs. Therefore, the distance reach can be extended to 5000 km. The Q reduces and BER increases as the data rate increases for both NRZ and RZ schemes over various transmission reach on different temperature and various aperture diameters.
Problémaérzékelés a koronavírus-járvány időszakában egy hátrányos helyzetű kistelepülésen
Authors: Szabó Lilla
Published: December 2022

A koronavírus-járvány számos területen fejtette ki negatív hatását, amelynek következményei társadalmi szinten is érzékelhetők. Ezen problémahalmazból a kutatásunk2 a probléma- és szegénységérzékelés vizsgálatára fókuszált a pandémia időszakában. A tanulmány aktuális képet ad egy dél-baranyai hátrányos helyzetű településen végzett kérdőíves kutatás eredményeinek bemutatásán keresztül a helyiek mindennapi életben érzékelt problémáiról, a problémamegoldás lehetséges módjairól, eszközeiről. A kutatás a koronavírus-járvány okozta hatások feltárásával arra kíván rámutatni, hogy milyen gazdasági, társadalmi változások mentek végbe, s milyen új problémák alakultak ki az elmúlt időszakban.
Effectiveness of Foam Rolling vs. Manual Therapy in Postexercise Recovery Interventions for Athletes: A Randomized Controlled Trial
Authors: Espí-López Gemma V. , Ruescas-Nicolau Maria-Arantzazu , Castellet-García María , Suso-Martí Luis , Cuenca-Martínez Ferran , Marques-Sule Elena
Published: December 2022

Espí-López, GV, Ruescas-Nicolau, MA, Castellet-García, M, Suso-Martí, L, Cuenca-Martínez, F, and Marques-Sule, E. Effectiveness of foam rolling vs. manual therapy in postexercise recovery interventions for athletes: A randomized controlled trial. J Strength Cond Res 37(6): e361–e368, 2023—Self-massage using foam rolling (FR) has been posited to have similar benefits as those traditionally associated with manual therapy (MT) but more economical, easy, and efficient. Despite the widespread use of this technique for the recovery of athletes, there is no evidence supporting the effectiveness of FR vs. MT. The purpose of this study was to assess the effects of FR self-massage in athletes after a high-intensity exercise session compared with a MT protocol. A randomized controlled trial was performed. Forty-seven volunteer amateur athletes (22.2 ± 2.5 years, 53.2% men) were divided into 3 groups: a FR group (n = 18, performed FR self-massage), a MT group (n = 15, received a MT protocol), and a control group (n = 14, passive recovery). After an intense exercise session, dynamic balance, lumbar and hip flexibility, and leg dynamic force were assessed before and after the intervention and 1 week later. Results showed that, in the FR group, dynamic balance scores increased for both limbs at postintervention (p = 0.001) and at follow-up (p = 0.001). These scores were higher for the FR group vs. the MT group at postintervention (right limb, p = 0.048) and at follow-up (right limb: p = 0.049; left limb: p = 0.048), although this variable differed at baseline. In all the groups, lumbar flexion increased at postintervention (p < 0.05), although it was only maintained in the FR group at follow-up (p = 0.048). In conclusion, self-massage with FR may be more effective than MT for the recovery of dynamic balance in athletes after intense exercise, although this result should be interpreted with caution. Foam rolling could have a relevant role in postexercise recovery to prevent injuries in athletes.
Subtype-Specific Roles of Ellipsoid Body Ring Neurons in Sleep Regulation inDrosophila
Authors: Yan Wei , Lin Hai , Yu Junwei , Wiggin Timothy D. , Wu Litao , Meng Zhiqiang , Liu Chang , Griffith Leslie C.
Published: December 2022

The ellipsoid body (EB) is a major structure of the central complex of theDrosophila melanogasterbrain. Twenty-two subtypes of EB ring neurons have been identified based on anatomic and morphologic characteristics by light-level microscopy and EM connectomics. A few studies have associated ring neurons with the regulation of sleep homeostasis and structure. However, cell type-specific and population interactions in the regulation of sleep remain unclear. Using an unbiased thermogenetic screen of EB drivers using female flies, we found the following: (1) multiple ring neurons are involved in the modulation of amount of sleep and structure in a synergistic manner; (2) analysis of data for ΔP(doze)/ΔP(wake) using a mixed Gaussian model detected 5 clusters of GAL4 drivers which had similar effects on sleep pressure and/or depth: lines driving arousal contained R4m neurons, whereas lines that increased sleep pressure had R3m cells; (3) a GLM analysis correlating ring cell subtype and activity-dependent changes in sleep parameters across all lines identified several cell types significantly associated with specific sleep effects: R3p was daytime sleep-promoting, and R4m was nighttime wake-promoting; and (4) R3d cells present in 5HT7-GAL4 and in GAL4 lines, which exclusively affect sleep structure, were found to contribute to fragmentation of sleep during both day and night. Thus, multiple subtypes of ring neurons distinctively control sleep amount and/or structure. The unique highly interconnected structure of the EB suggests a local-network model worth future investigation; understanding EB subtype interactions may provide insight how sleep circuits in general are structured.

SIGNIFICANCE STATEMENTHow multiple brain regions, with many cell types, can coherently regulate sleep remains unclear, but identification of cell type-specific roles can generate opportunities for understanding the principles of integration and cooperation. The ellipsoid body (EB) of the fly brain exhibits a high level of connectivity and functional heterogeneity yet is able to tune multiple behaviors in real-time, including sleep. Leveraging the powerful genetic tools available inDrosophilaand recent progress in the characterization of the morphology and connectivity of EB ring neurons, we identify several EB subtypes specifically associated with distinct aspects of sleep. Our findings will aid in revealing the rules of coding and integration in the brain.
Condensin pinches a short negatively supercoiled DNA loop during each round of ATP usage
Authors: Martínez‐García Belén , Dyson Sílvia , Segura Joana , Ayats Alba , Cutts Erin E , Gutierrez‐Escribano Pilar , Aragón Luís , Roca Joaquim
Published: December 2022

Condensin, an SMC (structural maintenance of chromosomes) protein complex, extrudes DNA loops using an ATP‐dependent mechanism that remains to be elucidated. Here, we show how condensin activity alters the topology of the interacting DNA. High condensin concentrations restrain positive DNA supercoils. However, in experimental conditions of DNA loop extrusion, condensin restrains negative supercoils. Namely, following ATP‐mediated loading onto DNA, each condensin complex constrains a DNA linking number difference (∆Lk) of −0.4. This ∆Lk increases to −0.8 during ATP binding and resets to −0.4 upon ATP hydrolysis. These changes in DNA topology do not involve DNA unwinding, do not spread outside the condensin‐DNA complex and can occur in the absence of the condensin subunit Ycg1. These findings indicate that during ATP binding, a short DNA domain delimited by condensin is pinched into a negatively supercoiled loop. We propose that this loop is the feeding segment of DNA that is subsequently merged to enlarge an extruding loop. Such a “pinch and merge” mechanism implies that two DNA‐binding sites produce the feeding loop, while a third site, plausibly involving Ycg1, might anchor the extruding loop.
Synthesis and Characterization of Activated Carbon from Lignocellulosic Biomass: Oil Palm Empty Fruit Bunches and Mahogany Sawdust
Authors: Arundina Ria Yolanda , Permana Indri , Togatorop Ester Rimma Suryani , Ismadi Ismadi , Kusumah Sukma Surya , Budiman Ismail , Subyakto Subyakto , Marlina Resti
Published: December 2022

Lignocellulosic biomass is a biological residue from the agricultural or forestry industry which is composed of polymeric cellulose, hemicellulose, lignin, and other extractive components. One of the products in the utilization of lignocellulosic biomass waste is activated carbon products. In this study, two types of lignocellulosic biomass waste were used, namely Empty Palm Oil Bunches (OPEFB) and Mahogany Sawdust (MS) to be converted into activated carbon using the hydrothermal-pyrolysis method. Potassium hydroxide (KOH) was used as an activating agent at high concentrations (50% w/w) to improve the adsorption mechanism in activated carbon material. Proximate analysis was carried out to obtain information related to yield, moisture content, and ash content. In addition, activated carbon samples were characterized using FTIR, XRD, and FESEM to observe the chemical bonds, structure, and morphology of activated carbon, respectively. The proximate analysis showed that the activated carbon sample had met the SNI 63-3730-1995 standard for technical activated carbon on the parameters of water content and ash content, while the FTIR spectrum showed the mechanism of biomass conversion from raw materials to activated carbon on a chemical bond approach. Furthermore, the XRD graph shows a reduction in the crystal size of the material from raw material to activated carbon material. Finally, the FESEM image shows a significant increase in the quality and quantity of pores on the carbon material before and after activation.
Effect of Ultrasonication Extraction Time on Determination of Flavonoid Levels in Ciplukan Plants
Authors: Hasyim Ummul Habibah , Sari Fatma , Kurniaty Ika , Ramadhani Annisya
Published: December 2022

Ciplukan contains bioactive substances in the form of flavonoids, saponins, alkaloids, polyphenols, vitamin C, stearic acid, palmitic acid. Bioactive substances from natural ingredients are known to function as immunomodulators that can increase the body's immune system, activate the body's natural defenses and restore immune system imbalances. Immunomodulators are important in studies related to the issue of the coronavirus disease 19 (Covid-19) pandemic. The purpose of this study was to determine the effect of the extraction time on the ultrasonic method on the flavonoid yield of ciplukan plants using methanol as a solvent. The method used is ultrasonication extraction with a variable extraction time. The analysis was carried out by qualitative analysis using a solution of qursetin to determine the concentration of flavonoids. The results of the study obtained the optimum flavonoid concentration at the extraction time of 15 minutes
Bio-Oil Production Using Waste Biomass via Pyrolysis Process: Mini Review
Authors: Nuraini Nuraini , Osman Noridah Binti , Astuti Erna
Published: December 2022

Pyrolysis process using abundantly available biomass waste fabric is a promising, renewable, and sustainable energy supply for bio-oil production. In this study, the pyrolysis of waste biomass determines the highest yield of diverse parameters of material type, temperature, reactor, method, and analysis used. From the differences in the parameters stated above, there is  an opportunity to select the proper parameters to get the desired nice and quantity of bio-oil and the very best bio-oil yield. The maximum yield of each bio-oil product for pyrolysis primarily based on the above parameters was 68.9%; 56.9%; 44.4%; 44.16%; 41.05%; 39.99%. The bio-oil made out of pyrolysis was changed into analyzed using GC-MS, ft-IR, NMR, TGA, SEM, Thermogravimetric analysis, HHV, FESEM evaluation methods and the substances used had been plastic, seaweeds, oat straw, rice straw , water hyacinth, timber sawdust, sawdust, microalgae.
Free Vibration Analysis of Sandwich Plate-Reinforced Foam Core Adopting Micro Aluminum Powder
Authors: Al-Waily Muhannad , Raad Hussam , Njim Emad Kadum
Published: December 2022

Analytical study of free vibration behavior of foam core sandwich plates strengthened with Aluminum micro spherical powder were presented in this paper. Sandwich plate with polyurethane foam core sandwiched between two Aluminum faces. To calculate the natural frequencies, use Kirchhoff theory to drive the equation of sandwich plate vibration. The stiffness characteristics of a foam-Aluminum core were evaluated by micro particle composite equations. The findings reveal that the impact of filling foam is effective, according to the free vibration analysis, the sandwich plate's free vibration and static behavior can be improved by using micro spherical powder foam in the vacant spherical gaps of the foam core. In comparison to other cores, the core foam-aluminum sandwich plate deflects less.
Modeling of the phase-structural state in a hybrid multicomponent alloy with a high boron content
Authors: Chabak Yu.G. , Golinskyi М.А. , Efremenko V.G. , Shimizu К. , Halfa H. , Zurnadzhy V.І. , Efremenko B.V. , Kovbasiuk Т.М.
Published: December 2022

The present work is focused on analyzing the thermodynamically equilibrium path of structure formation in a multi-component Fe-W-Mo-Cr-Ti-Mn-Si alloy of tribotechnical purpose, containing 0.72 wt. % C and 2.75 wt. % B is analyzed. Computer simulation of the crystallization process was performed using the program “Thermo-Calc Software”. It was found that the alloy belongs to the hyper-eutectic compositions, since its crystallization begins at 1472 oC with the formation of primary boride WB and carbide TiC. After a series of subsequent eutectic reactions (in the range of 1126-923 oC) and solid-phase transformations, a set of equilibrium phases is formed in the alloy, which at room temperature consists of borides WB, MoV, Fe2B, Cr4B, Mn4B, carbides TiC, M7C3, and ferrite. The total volume fraction of borides and carbides is 45.05 vol. %. A comparison of the obtained data with the results of the study of the manufactured alloy showed that the simulation with “Thermo-Calc Software” provides satisfactory adequacy in predicting the structure in the alloys of the selected alloying system.
DISPUTE SETTLEMENT IN THE FREE TRADE AGREEMENTS OF TURKEY
Authors: GÖKER Mustafa
Published: December 2022

The order of World Trade Organization (WTO), which deals with international trade at the global level, allows the handling of trade also at the regional level under certain conditions. In this context, regional trade agreements (RTA) have been signed and this trend continues. Such treaties have been named differently whereas they have essentially same functions. On the other hand, while there is an advanced dispute settlement mechanism within the WTO, similar mechanisms are also included in RTAs. Like other WTO members, Turkey has concluded bilateral RTAs in the form of Free Trade Agreement (FTA), which include dispute resolution provisions. In the design of these settlement mechanisms, a place in the spectrum of political/diplomatic and legal character has been adopted with varying weights. Although the dispute settlement mechanisms of FTAs have more advanced provisions in recent years compared to previous ones, there are still examples where important deficiencies and gaps are noticeable.
Una revisión de la literatura académica: 20 años de la política exterior del gobierno del Partido de la Justicia y el Desarrollo (AKP) en Turquía
Authors: Rodríguez-López Carmen , Lois María
Published: December 2022

El siguiente texto lleva a cabo una revisión de la literatura académica centrada en la política exterior del AKP en el periodo 2002-2022 con el objeto de contextualizar el contenido del monográfico especial “Turquía: repertorios de cooperación y conflicto en el Mediterráneo oriental y la región MENA”.
El monográfico se centra en abordar los repertorios de actuación de Turquía en el ámbito de su política exterior, muy especialmente durante episodios contenciosos, pero no sólo, con terceros Estados. Con el objeto de contextualizar las relaciones bilaterales objeto de análisis, el presente artículo recoge las principales tendencias en la política exterior turca de los últimos años, con las que enmarcar y explicar el contexto en el que se producirán dichas relaciones, así como el recurso a diferentes herramientas de poder político en la arena internacional.
Esta visión panorámica permite ahondar en la dirección y alcance de unas relaciones exteriores que han experimentado transformaciones sustanciales en los últimos años. El artículo se centra en los textos que han propuesto una caracterización por etapas de la política exterior del AKP, plantea en detalle la génesis y el debate en torno a los conceptos de neo-otomanismo y euroasianismo comúnmente utilizados para explicar diferentes momentos de la política exterior turca, y cierra con un epígrafe destinado a las herramientas de poder duro, poder blando y de diplomacia coercitiva utilizadas por el partido en el poder.
Las relaciones de cooperación y rivalidad entre Turquía y Siria: impacto del conflicto sirio en la política exterior turca y las implicaciones internacionales
Authors: Calatrava-García Adolfo , Durán Cenit Marién
Published: December 2022

Siria y Turquía son un ejemplo claro de frenemies: con relaciones determinadas por dinámicas de conflicto y cooperación desde su constitución como Estados. Después de una situación de grave tensión en los años ochenta y noventa, se produce una década de acercamiento. Esta dinámica se rompe con la “Primavera Árabe” y el inicio del conflicto sirio. En este artículo entendemos esta circunstancia como un “episodio contencioso”, capaz de cambiar las relaciones amigo/enemigo; para ello se estudian los acontecimientos y eventos que llevaron en los primeros meses del conflicto al cambio del sentido de estas relaciones y las implicaciones internacionales.
El sionismo y la nueva extrema derecha. Historia de unas relaciones y nuevas alianzas
Authors: Basallote Marín Antonio
Published: December 2022

Partiendo del análisis del sionismo como ideología y como movimiento político, el presente trabajo tiene como principal objetivo analizar el contexto y la historia de unas renovadas alianzas entre el sionismo institucional con las derechas de otros países, sobre todo con la “nueva extrema derecha” en Europa, Estados Unidos y Brasil. Para ello, pretendemos identificar los factores que han favorecido el refuerzo de esas relaciones, que consideramos son tanto de estratégica política como de convergencia ideológica, como ocurre con el racismo y la islamofobia.
Exploitation, Labor and Sex Trafficking of Children and Adolescents: Health Care Needs of Patients
Authors: Greenbaum Jordan , Kaplan Dana , Young Janine ,   COUNCIL ON CHILD ABUSE AND NEGLECT, Haney Suzanne B. , Sirotnak Andrew P. , Asnes Andrea Gottsegen , Gavril Amy R. , Gilmartin Amanda Bird Hoffert , Girardet Rebecca Greenlee , Heavilin Nancy D. , Laskey Antoinette , Messner Stephen A. , Mohr Bethany A. , Nienow Shalon Marie , Rosado Norell , Forkey Heather , Keefe Rachael , Keeshin Brooks , Matjasko Jennifer , Edward Heather , Stedt Elaine , Hurley Tammy Piazza ,   COUNCIL ON IMMIGRANT CHILD AND FAMILY HEALTH, Linton Julie , Gutierrez Raul , Caballero Tania , Falusi Olanrewaju “Lanre” Omojokun , Giri Minal , Griffin Marsha , Ibrahim Anisa , Mukerjee Kimberly , Shah Sural , Shapiro Alan , Young Janine
Published: December 2022

Exploitation and labor and sex trafficking of children and adolescents is a major public health problem in the United States and throughout the world. Significant numbers of US and non-US–born children and adolescents (including unaccompanied immigrant minors) are affected by this growing concern and may experience a range of serious physical and mental health problems associated with human trafficking and exploitation (T/E). Despite these considerations, there is limited information available for health care providers regarding the nature and scope of T/E and how providers may help recognize and protect children and adolescents. Knowledge of risk factors, recruitment practices, possible indicators of T/E, and common medical, mental, and emotional health problems experienced by affected individuals will assist health care providers in recognizing vulnerable children and adolescents and responding appropriately. A trauma-informed, rights-based, culturally sensitive approach helps providers identify and treat patients who have experienced or are at risk for T/E. As health care providers, educators, and leaders in child advocacy and development, pediatricians play an important role in addressing the public health issues faced by children and adolescents who experience exploitation and trafficking. Working across disciplines with professionals in the community, health care providers can offer evidence-based medical screening, treatment, and holistic services to individuals who have experienced T/E and assist vulnerable patients and families in recognizing signs of T/E.
Maintaining and Improving the Oral Health of Young Children
Authors: Krol David M. , Whelan Kaitlin ,   THE SECTION ON ORAL HEALTH
Published: December 2022

Oral health is an integral part of the overall health of children. Dental caries is a common and chronic disease process with significant short- and long-term consequences. The prevalence of dental caries remains greater than 40% among children 2 to 19 years of age. Although dental visits have increased in all age, race, and geographic categories in the United States, disparities continue to exist, and a significant portion of children have difficulty accessing dental care. As health care professionals responsible for the overall health of children, pediatricians frequently confront morbidity associated with dental caries. Because the youngest children visit the pediatrician more often than they visit the dentist, it is important that pediatricians be knowledgeable about the disease process of dental caries, prevention of disease, interventions to maintain and restore health, and the social determinants of children’s oral health.
Congenital Hypothyroidism: Screening and Management
Authors: Rose Susan R. , Wassner Ari J. , Wintergerst Kupper A. , Yayah-Jones Nana-Hawa , Hopkin Robert J. , Chuang Janet , Smith Jessica R. , Abell Katherine , LaFranchi Stephen H. ,   SECTION ON ENDOCRINOLOGY EXECUTIVE COMMITTEE, Wintergerst Kupper A. , Bethin Kathleen E. , Brodsky Jill L. , Jelley David H. , Marshall Bess A. , Mastrandrea Lucy D. , Lynch Jane L. , Laskosz Laura ,   COUNCIL ON GENETICS EXECUTIVE COMMITTEE, Burke Leah W. , Geleske Timothy A. , Holm Ingrid A. , Introne Wendy J. , Jones Kelly , Lyons Michael J. , Monteil Danielle C. , Pritchard Amanda B. , Smith Trapane Pamela Lyn , Vergano Samantha A. , Weaver Kathryn , Alexander Aimee A. , Cunniff Christopher , Null Mary E. , Parisi Melissa A. , Ralson Steven J , Scott Joan , Spire Paul
Published: December 2022

Untreated congenital hypothyroidism (CH) leads to intellectual disabilities. Prompt diagnosis by newborn screening (NBS) leading to early and adequate treatment results in grossly normal neurocognitive outcomes in adulthood. However, NBS for hypothyroidism is not yet established in all countries globally. Seventy percent of neonates worldwide do not undergo NBS.

The initial treatment of CH is levothyroxine, 10 to 15 mcg/kg daily. The goals of treatment are to maintain consistent euthyroidism with normal thyroid-stimulating hormone and free thyroxine in the upper half of the age-specific reference range during the first 3 years of life. Controversy remains regarding detection of thyroid dysfunction and optimal management of special populations, including preterm or low-birth weight infants and infants with transient or mild CH, trisomy 21, or central hypothyroidism.

Newborn screening alone is not sufficient to prevent adverse outcomes from CH in a pediatric population. In addition to NBS, the management of CH requires timely confirmation of the diagnosis, accurate interpretation of thyroid function testing, effective treatment, and consistent follow-up. Physicians need to consider hypothyroidism in the face of clinical symptoms, even if NBS thyroid test results are normal. When clinical symptoms and signs of hypothyroidism are present (such as large posterior fontanelle, large tongue, umbilical hernia, prolonged jaundice, constipation, lethargy, and/or hypothermia), measurement of serum thyroid-stimulating hormone and free thyroxine is indicated, regardless of NBS results.
Short Text Messages Gateway-Based Expert System for Diagnosis of Skin Disease
Authors: Hafid Afdhil , Hasanuddin Hasanuddin , Ismail Muhammad
Published: December 2022

Skin disease is the most common infectious disease in people of all ages. In Indonesia, skin diseases are mostly caused by bacterial, fungal, parasitic, and allergic basic diseases. This is different from western countries which are more influenced by degenerative factors. Apart from differences in causes, other factors such as climate, habits and environment also contribute to differences in the clinical picture of skin diseases. Health service policy is one of the main components. Improving good services should not stop with the development of good infrastructure, or only to the examination or diagnosis of doctors for patients, but good health care also lies in how to do it so that people can get health services easily. Cases of ineffective health services often occur in the community, ranging from slow hospital services, practice malls, to a common problem, namely the queuing process that must be carried out by prospective patients who are going to a general practitioner or specialist. In improving the service, you want to develop a problem using the system. the system to be developed is a system that will adopt expert knowledge into a server or also known as an expert system. The expert system to be built will be based on Short text messages or SMS (Short Message Service). This system provides SMS sending services from a website or server to a cellphone number, either free or for a fee. Technology like this is called the SMS Gateway.
How can the restorative idea survive in schools? Experiences of a professional development programme
Authors: Hera Gabor
Published: December 2022

This paper aims to detect the motivations, structures, and conditions that both promote and hinder commitment and buy-in regarding the implementation of restorative practices in schools. In addition, the components that contribute to the long-term sustainability of the restorative idea in school settings are also identified. The article summarizes the ideas and experiences of the trainers at the International Institute for Restorative Practices who were interviewed within the framework of a research programme. These trainers were responsible for providing professional development for middle and high schools in many states of the United States. As the author concludes, without thorough assessment of implementation readiness, professional development may fail and the restorative idea does not take root in schools.