bluuebunny/crossref_metadata_2025 huggingface dataset:
The use of a vaginal therapeutic system with prostaglandin for induction of labor
Authors: Baev O. R. , Gusar V. A. , Gaydarova A. R. , Edilberg I. V.
Published: October 2022

Introduction. Induction of labor is one of the most frequent procedures in modern obstetrics, which reduces the frequency of cesarean section and improves pregnancy outcomes. However, the effectiveness and safety of labor induction methods vary. Currently, the vaginal therapeutic system (SVT) with dinoprostone is certified for use for childbirth in Russia.   Aim. To conduct a review of the literature data and a pilot study of the effectiveness and safety of the vaginal therapeutic system with dinoprostone for induction of labor.

   Materials and methods. A review of the literature for 2001–2022 devoted to the use of vaginal systems with gradual release of prostaglandin for induction of labor was conducted. Additionally, a prospective observational study of the effectiveness and safety of the dinoprostone system was conducted in 18 pregnant women. The evaluation criteria were: the frequency of labor, the degree of maturation of the cervix on the Bishop scale, as well as the frequency of vaginal delivery.   Results. Literature data indicate that SVT with dinoprostone has comparable efficacy with other methods of pre-induction / induction of labor. The system with dinoprostone has a lower frequency of the side effect of “tachysystole” than the system with misoprostol. Compared with mechanical methods, SVT is assotiated with a lower frequency of oxytocin use. The use of SVT with dinoprostone showed an efficiency of 77.8% (in terms of the of labor start or cervical ripening). No side effects requiring termination of labor induction were registered in our study.   Conclusions. Thus, vaginal insertion with prostaglandin E2 – dinoprostone is an effective and safe method of pre-induction of labor. Taking into account the small sample size in our work, it is of interest to continue research in order to obtain more complete data and in comparison with other methods.
Some aspects of adherence to combined hormonal contraception in young women
Authors: Zhukovskaya I. G. , Khuzina L. F.
Published: October 2022

Introduction. In addition to being protective against unwanted pregnancies, combined hormonal contraceptives (CHCs) can improve health and quality of life of women. The awareness of Russian women about CHCs is 85 %, however, only 13 % of women in Russia have a long-term experience with CHCs. This is why, it is essential to analyse drivers of adherence of young women to CHCs, and the reasons for refusal of them.   Aim. Identification of the reasons affecting adherence to СHС in young women.   Materials and methods. Group 1 consisted of 36 women who have tried using СHС, but stopped taking: 1A (19 women) – up to 1 year, 1B (17 women) – from 1 to 3 years; group 2 – 35 women who have never used СHС.   Results. The level of education in group 2 was significantly lower, patients with secondary general education prevailed. Despite the high awareness of the benefits of СHС, the number of real users of these drugs was only 50.7 %, while half of them used CHС for 9 months on average. The refusal to use СHС in group 2 was motivated by the possible development of side effects, the lack of need for regular contraception, which requires improvement of counseling on using СHС, taking into account the characteristics of the contingent of patients. The reason for the rejection of СHС in groups 1A and 1B, regardless of the duration of use, was side effects in 42.1 and 47.1 % of cases, respectively, which included: headaches, decreased libido; nausea, epigastric pain, intermenstrual spotting, weight gain, emotional lability.   Conclusion. Taking into account the level of education of patients and their needs, high-quality structured counseling when choosing a method of contraception will increase compliance with the use of СHСs, increase the frequency and duration of using СHСs.
Kinetics Study of Alumina Leaching from Ogbunike Clay Using Hydrochloric Acid
Authors: Okwuzu Francis Tobechukwu , Igwegbe Chinenye Adaobi , Okafor Vincent Nwoye , Ugwu Jonathan Ifeanyi , Obi Chinazamekpere Valerie
Published: October 2022

The kinetics study of alumina leaching from ogbunike clay was carried out using a solution of hydrochloric acid (HCl) for alumina dissolution. Variations in process parameters such as calcination temperature, leaching temperature, acid concentration, particle size, and solid-to-liquid ratio were considered for the leaching of alumina. The shrinking core model was used to analyze the experimental data. Alumina removal is feasible with 24.035% extractable alumina, and this can improve the economic value of ogbunike clay, which can be an alternative raw material in Nigeria’s aluminum industries. According to the data the dissolution rate increases with increasing calcination temperature, leaching temperature and acid concentration and decreasing particle size and solid-to-liquid ratio. The statistical and graphical analysis revealed that the dissolution followed the product layer diffusion-controlled semi-empirical kinetic model. The activation energy was calculated to be 18.36 kJ/mol for HCl. The optimum conditions for the dissolution of the alumina in HCI include activation temperature of 700 ⁰C for 60 minutes, leaching temperature of 90 ⁰C, HCl concentration of 3 M, particle size of 75 µm, and the solid-liquid ratio of 0.2 g/ml yielding the alumina dissolution rate of 84.72%. The kinetic data can be used to construct large-scale manufacturing equipment.
Pendampingan Pengembangan Nilai Budaya Daerah Melalui Konten Web Series
Authors:   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Sugiarto Claudia , Aditya Sanjaya I Dewa Gede ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Hydanta Jan Asher ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Kurniasari Jessica Gabrielle ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Fernando Kevin ,   Universitas Prasetiya Mulya BSD City Kavling Edutown I.1, Jl. BSD Raya Utama, BSD City, Kec. Pagedangan, Tangerang, Banten 15339, Indonesia., Sendana Ravella ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Raharjo Ricardo Anthony ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820, Cahyadi William Anthony ,   Universitas Prasetiya Mulya, Edutown BSD Campus Kavling Edu I.1, Jl. BSD Raya Utama, BSD City, Serpong - Tangerang , Indonesia 15820
Published: October 2022

Community Development (COMDEV) activities at Prasetiya Mulya University are carried out with the aim of developing businesses and products produced by partners in collaboration with the University. Partners who collaborate with the University are majoring in film from Banjarmasin Vocational School. The challenge that is owned by SMK Banjarmasin is how to find the right target market but does not eliminate the strong Banjar regional culture. Films produced by partners so far have only been published in film festival competitions, so they are less profitable. Based on the situation analysis conducted by the group, several improvements have been made in terms of operations, marketing, human resources and finance. These improvement steps were realized with the existence of new social media and also the creation of a web series that was broadcast on Youtube with the concept of "Palui" which is one of the cultures in the Banjar area. Writing this journal aims to provide an overview of the problems that exist in film production at SMK Banjarmasin and corrective steps that can be taken to maximize the results of film production at SMK Banjarmasin.
Relações de parentesco nas mulheres Karipuna
Authors: Soares Ana Manoela Primo dos Santos
Published: October 2022

Este artigo é redigido por uma indígena e antropóloga que possui suas raízes no povo Karipuna do Amapá. No texto trago reflexões acerca do parentesco e das relações intergeracionais entre as mulheres de uma mesma família, originárias de um único Território: a aldeia Santa Isabel na Terra Indígena Uaçá (Oiapoque - AP). Estando eu mesma, inserida nas relações de parentesco que proponho apresentar na pesquisa. Há no artigo, ainda, as relações de parentesco Karipuna desenvolvidas entre as mulheres e os “karuãna”. Além das relações desenvolvidas através dos sonhos, objetos e grafismos como substâncias que podem produzem parentesco no cotidiano. Ao longo deste escrito, através de meus relatos, irei explicar como estas relações surgem para mim e como elas se conectam entre si e no sistema Karipuna.
O TURISMO COMO CONTRIBUTO AO PLANEJAMENTO E DESENVOLVIMENTO REGIONAL
Authors: Pagnussat Camara Inara
Published: October 2022

A área do turismo no Brasil sempre foi muito paradoxal. Ao mesmo tempo que qualquer um é capaz de reconhecer as potencialidades naturais e a riqueza histórico-cultural do país, entendendo as diferentes possibilidades de ganhos econômicos com a atividade e reconhecendo a existência de um significativo grupo de empresários que atuam na administração de pequenos negócios, ainda temos grandes desafios ao planejamento turístico. Esta pesquisa relata uma experiência didática realizada desde 2017 no curso de Arquitetura e Urbanismo da Universidade do Oeste de Santa Catarina, Campus de Videira, que pretende relacionar o desenvolvimento econômico com o turismo, o qual está longe de ser consensual, e a interpretação histórica da Região do Contestado para a construção da memória identitária. Buscamos refletir sobre o uso turístico dado às interpretações dos habitantes e o legado histórico socialmente determinado e preservado pela memória coletiva, que podem os chamar de patrimônio cultural (material ou imaterial) aliado ao planejamento regional, prevendo ganhos econômicos e garantindo os objetivos de Desenvolvimento Sustentável da ONU para a Agenda 2030. A metodologia aproxima-se de duas áreas de saber ao objeto histórico: definir um evento no passado/presente, buscando apreendê-lo, interpretar e publicizar a interpretação e a reflexão intelectual, onde, em ambos os casos, o aluno é o personagem principal do processo de aprendizagem.
ENTRE CÍRCULOS
Authors: Troncoso Marcia Urbano , Garcia Lupi Vergara Lizandra
Published: October 2022

O tratamento de crianças com Transtorno do Espectro Autista (TEA) é um tema de saúde coletiva que congrega diversas áreas de conhecimento. O objetivo deste artigo é conhecer a percepção dos profissionais de saúde sobre a importância dos espaços urbanos lúdicos para crianças com TEA. Em entrevistas sobre o assunto, terapeutas expressaram preocupação com a falta de ambientes inclusivos nas cidades. Para eles, a arquitetura poderia servir como capa protetora, mediando o contato de seus pacientes com o exterior, de forma gradual e convidativa. O autismo infantil e a cidade vista como um grande playground foram objetos da revisão bibliográfica deste trabalho. A aplicação do método da análise de conteúdo permitiu a organização de noventa extensas respostas, sintetizadas em quadros e gráficos. As questões tentam verificar se e como os ambientes lúdicos poderiam ajudar crianças com TEA a compreender as diferenças entre o seu EU e o MUNDO à sua volta. Os resultados apontam para a necessidade de arquitetos e urbanistas, trabalhando em equipes interdisciplinares com profissionais de saúde, em prol da na concepção de ambientes acolhedores voltados a cidades mais inclusivas e amigáveis para todos.
ENTREVISTA À ARQUITETA NÍCIA BORMANN
Authors: Silva Heitor de Andrade , Paes Bormann Nicia
Published: October 2022

Este texto consiste em uma entrevista concedida pela arquiteta e professora carioca, radicada no Ceará, Nícia `Paes Bormann, no dia 25 de julho de 2022, ao professor Heitor Andrade (integrante do Grupo PROJETARr/UFRN). Contribui com a série “ 'Mulheres Arquitetas' – Parte I: Arquitetas Nordestinas", da Revista Projetar.
Separating Features From Functionality in Vaccination Apps: Computational Analysis
Authors: Shaw Jr George , Nadkarni Devaki , Phann Eric , Sielaty Rachel , Ledenyi Madeleine , Abnowf Razaan , Xu Qian , Arredondo Paul , Chen Shi
Published: October 2022

Background

Some latest estimates show that approximately 95% of Americans own a smartphone with numerous functions such as SMS text messaging, the ability to take high-resolution pictures, and mobile software apps. Mobile health apps focusing on vaccination and immunization have proliferated in the digital health information technology market. Mobile health apps have the potential to positively affect vaccination coverage. However, their general functionality, user and disease coverage, and exchange of information have not been comprehensively studied or evaluated computationally.

Objective

The primary aim of this study is to develop a computational method to explore the descriptive, usability, information exchange, and privacy features of vaccination apps, which can inform vaccination app design. Furthermore, we sought to identify potential limitations and drawbacks in the apps’ design, readability, and information exchange abilities.

Methods

A comprehensive codebook was developed to conduct a content analysis on vaccination apps’ descriptive, usability, information exchange, and privacy features. The search and selection process for vaccination-related apps was conducted from March to May 2019. We identified a total of 211 apps across both platforms, with iOS and Android representing 62.1% (131/211) and 37.9% (80/211) of the apps, respectively. Of the 211 apps, 119 (56.4%) were included in the final study analysis, with 42 features evaluated according to the developed codebook. The apps selected were a mix of apps used in the United States and internationally. Principal component analysis was used to reduce the dimensionality of the data. Furthermore, cluster analysis was used with unsupervised machine learning to determine patterns within the data to group the apps based on preselected features.

Results

The results indicated that readability and information exchange were highly correlated features based on principal component analysis. Of the 119 apps, 53 (44.5%) were iOS apps, 55 (46.2%) were for the Android operating system, and 11 (9.2%) could be found on both platforms. Cluster 1 of the k-means analysis contained 22.7% (27/119) of the apps; these were shown to have the highest percentage of features represented among the selected features.

Conclusions

We conclude that our computational method was able to identify important features of vaccination apps correlating with end user experience and categorize those apps through cluster analysis. Collaborating with clinical health providers and public health officials during design and development can improve the overall functionality of the apps.
Prediction of COVID-19 Infections for Municipalities in the Netherlands: Algorithm Development and Interpretation
Authors: van der Ploeg Tjeerd , Gobbens Robbert J J
Published: October 2022

Background

COVID-19 was first identified in December 2019 in the city of Wuhan, China. The virus quickly spread and was declared a pandemic on March 11, 2020. After infection, symptoms such as fever, a (dry) cough, nasal congestion, and fatigue can develop. In some cases, the virus causes severe complications such as pneumonia and dyspnea and could result in death. The virus also spread rapidly in the Netherlands, a small and densely populated country with an aging population. Health care in the Netherlands is of a high standard, but there were nevertheless problems with hospital capacity, such as the number of available beds and staff. There were also regions and municipalities that were hit harder than others. In the Netherlands, there are important data sources available for daily COVID-19 numbers and information about municipalities.

Objective

We aimed to predict the cumulative number of confirmed COVID-19 infections per 10,000 inhabitants per municipality in the Netherlands, using a data set with the properties of 355 municipalities in the Netherlands and advanced modeling techniques.

Methods

We collected relevant static data per municipality from data sources that were available in the Dutch public domain and merged these data with the dynamic daily number of infections from January 1, 2020, to May 9, 2021, resulting in a data set with 355 municipalities in the Netherlands and variables grouped into 20 topics. The modeling techniques random forest and multiple fractional polynomials were used to construct a prediction model for predicting the cumulative number of confirmed COVID-19 infections per 10,000 inhabitants per municipality in the Netherlands.

Results

The final prediction model had an R2 of 0.63. Important properties for predicting the cumulative number of confirmed COVID-19 infections per 10,000 inhabitants in a municipality in the Netherlands were exposure to particulate matter with diameters <10 μm (PM10) in the air, the percentage of Labour party voters, and the number of children in a household.

Conclusions

Data about municipality properties in relation to the cumulative number of confirmed infections in a municipality in the Netherlands can give insight into the most important properties of a municipality for predicting the cumulative number of confirmed COVID-19 infections per 10,000 inhabitants in a municipality. This insight can provide policy makers with tools to cope with COVID-19 and may also be of value in the event of a future pandemic, so that municipalities are better prepared.
Nurse Practitioner–Led Integrated Rapid Access to HIV Prevention for People Who Inject Drugs (iRaPID): Protocol for a Pilot Randomized Controlled Trial
Authors: Khati Antoine , Altice Frederick L , Vlahov David , Eger William H , Lee Jessica , Bohonnon Terry , Wickersham Jeffrey A , Maviglia Francesca , Copenhaver Nicholas , Shrestha Roman
Published: October 2022

Background

The ongoing volatile opioid epidemic remains a significant public health concern, alongside continued outbreaks of HIV and hepatitis C virus among people who inject drugs. The limited access to and scale-up of medications for opioid use disorder (MOUD) among people who inject drugs, coupled with multilevel barriers to pre-exposure prophylaxis (PrEP) uptake, makes it imperative to integrate evidence-based risk reduction and HIV prevention strategies in innovative ways. To address this need, we developed an integrated rapid access to HIV prevention program for people who inject drugs (iRaPID) that incorporates same-day PrEP and MOUD for this population.

Objective

The primary objective of this pilot study is to assess the feasibility and acceptability of the program and evaluate its preliminary efficacy on PrEP and MOUD uptake for a future randomized controlled trial (RCT). We also aim to explore information on the implementation of the program in a real-world setting using a type I hybrid implementation trial design.

Methods

Using a type I hybrid implementation trial design, we are pilot testing the nurse practitioner–led iRaPID program while exploring information on its implementation in a real-world setting. Specifically, we will assess the feasibility and acceptability of the iRaPID program and evaluate its preliminary efficacy on PrEP and MOUD uptake in a pilot RCT. The enrolled 50 people who inject drugs will be randomized (1:1) to either iRaPID or treatment as usual (TAU). Behavioral assessments will occur at baseline, and at 1, 3, and 6 months. Additionally, we will conduct a process evaluation of the delivery and implementation of the iRaPID program to collect information for future implementation.

Results

Recruitment began in July 2021 and was completed in August 2022. Data collection is planned through February 2023. The Institutional Review Boards at Yale University and the University of Connecticut approved this study (2000028740).

Conclusions

This prospective pilot study will test a nurse practitioner–led, integrated HIV prevention program that incorporates same-day PrEP and MOUD for people who inject drugs. This low-threshold protocol delivers integrated prevention via one-stop shopping under the direction of nurse practitioners. iRaPID seeks to overcome barriers to delayed PrEP and MOUD initiation, which is crucial for people who inject drugs who have had minimal access to evidence-based prevention.

Trial Registration

ClinicalTrials.gov NCT04531670; https://clinicaltrials.gov/ct2/show/NCT04531670

International Registered Report Identifier (IRRID)

DERR1-10.2196/42585
Pathophysiological basis of sarcopenia— a chronic complication of diabetes
Authors: Кovalchuk A.V. , Zinych О.В. , Кushnarova N.M. , Prybyla О.В. , Shyshkan-Shyshova K.O.
Published: October 2022

The review considers the problem of sarcopenia, a muscle weakness and loss of mass, quality and strength of skeletal muscles, which often accompanies type 2 diabetes, especially in the elderly. Recently, sarcopenia has been considered as one of the complications of diabetes, which is associated with an increase in the frequency of cardiovascular complications, the need for hospitalization, and patient mortality. The molecular mechanisms of muscle atrophy in sarcopenia are associated with a violation of the anabolic-catabolic balance in muscles and their energy supply, fatty infiltration and shifts in proteostasis (decreasing the synthesis of muscle proteins and increasing their degradation), mitochondrial dysfunction. Insulin resistance, oxidative stress, accumulation of abdominal and ectopic fat, local inflammation play a key role in the pathogenesis of both sarcopenia and dysmetabolic diabetic complications, i.e., there is a bidirectional relationship between these pathological conditions, which mutually reinforce each other’s negative consequences. According to clinical observations, the risk of sarcopenia in patients with diabetes is 3–4 times higher than in people without diabetes, while the presence of sarcopenia increases the risk of reduced work capacity, disability, mortality, and worsening of diabetes control. These data indicate the feasibility of screening for signs of sarcopenia in patients with type 2 diabetes, especially in the older age group, using dynamic tests, as well as bone monitoring, to prevent the risk of falls and fractures. Antidiabetic therapy for such patients should include drugs that help preserve muscle and bone tissue (have an anabolic effect), do not increase the risk of hypoglycemia and gastrointestinal disorders. According to the literature, the safest preparations include the biguanide metformin, dipeptidyl peptidase inhibitors, and insulin. Sulfonylurea derivatives, thiazolidinediones, glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter-2 inhibitors are not recommended, as they can cause undesirable effects in weakened elderly people. Timely diagnosis of sarcopenia is important to prevent the deterioration of muscle function (through the rehabilitation of the musculoskeletal system using adaptive physical exercises and diet modification) and to improve the quality of life of patients with type 2 diabetes. In turn, improving the prevention and treatment of diabetes in the early stages can also help prevent the development of sarcopenia and its complications.
Parametric Optimization of 3D Printing Process
Authors: Katre Mr. Nilesh , Gonare Mr. Rahul , Rahangdale Mr. Raj , Karade Mr. Shrejas , Maskare Mr. Shubham , Hulke Mr. Harshal , Baitule Prof. Hemant
Published: October 2022

Abstract: The term “three-dimensional printing” refers to a variety of manufacturing processes used to create a variety of things. Nine identically sized models were created utilising a low-cost 3D printer and polylactic acid (PLA) material using the design of experiments approach (DOE). Infill %, Layer thickness, and Nozzle diameter were the three input parameters that were examined, each of which had three levels. The ideal polylactic acid impact resistance (PLA). Through compressive testing, this study’s goal is to comprehend mechanical characteristics, economic benefits, and environmental advantages. The study’s findings will offer a thorough mechanical inventory for product design and production. This study also points to potential improvements in infill pattern design for additive manufacturing.
Dinâmica familiar, práticas educativas e problemas emocionais/comportamentais: percepção parental sobre adolescentes com altas habilidades ou superdotação intelectiva
Authors: Dellatorre Andrade Erica Isabel , Fonseca Ana Carolina , Macedo de Saraiva Lisboa Carolina , Marin Angela Helena
Published: October 2022

Objetivou deste trabalho foi compreender a percepção de pais de adolescentes com altas habilidades ou superdotação (AH/SD) intelectiva sobre dinâmica familiar, práticas educativas utilizadas, indicadores de problemas emocionais/comportamentais e perspectivas de futuro em relação aos filhos/as. Trata-se de uma pesquisa exploratória e qualitativa, da qual participaram três mães e dois pais. Todos responderam individualmente uma entrevista semiestruturada constituída por 15 tópicos que versavam sobre rotina familiar, práticas educativas e preocupações parentais com os filhos. A análise temática dedutiva indicou que os pais identificaram as altas habilidades dos filhos, porém necessitavam de informações adicionais para gerenciar tais características. Observou-se uma interação familiar carente em alguns casos e a coexistência de práticas autoritativas e autoritárias em uma mesma família. Constatou-se o receio com a expressão de agressividade e isolamento dos filhos/as e o quanto isso poderia propiciar o envolvimento em atos ilícitos. Assim, verificou-se que os pais estão atentos aos filhos, mas apresentam dúvidas sobre como educá-los.
Regulatory requirement for the approval of Generic Drug in Vietnam as per ASEAN Common Technical Dossier (ACTD)
Authors: Panchal Vruddhi , Patel Utsav , Movaliya Vinit , Vaghela Khushboo , Kanki Niranjan , Zaveri Maitreyi
Published: October 2022

Drug approval process differs from one country to another country. The purpose of this study is to give a comparative overview on generic drug market regulation in ASEAN Countries Cambodia and Vietnam. The aim of study is to facilitate proper knowledge regarding main critical issues, differences as well as similarities of related drug regulation. There is a different requirement for registration of generic product in each regulatory system but also comprises of some similar outline that includes some common rules. These are variances and regulatory hurdles such as Number of batches for submission in dossier, stability conditions, registration of product, analysis, bioequivalence and clinical study requirement. ASEAN countries for generic drug product approval ACTD submitted to country specific authority. For solid oral dosage forms as per ASEAN guideline there are 4 parts have to be submitted. Part I contains Administrative requirements which is not a part of common technical document. Part II is Quality contains 3 sections that are a) Table of Content b) Quality overall Summary c) Body of data. Part III contains Non clinical. Part IV contains Clinical data. For the generic drug product Part III and Part IV is not required.
The Enlightenment of the Management of EU Notified Bodies to China's Introduction of Third-Party Institutions for Medical Device Supervision
Authors: Hou Qingqing , Xu Yiming , Zhang Dawei , Liang Yi
Published: October 2022

Objective: By introducing the pilot situation of post-market supervision of medical devices purchased by third-party institutions in Jiangsu Province, China, the problems exposed by them were analyzed. At the same time, it draws on relevant advanced experience in the management of EU notified bodies to provide suggestions for optimizing China's follow-up practices and promoting social co-governance supervision.

Method: Conduct on-the-spot investigations in Jiangsu Provincial Food and Drug Administration, China, conduct interviews with regulators on the progress of the project, and conduct in-depth communication. A large number of inquiries about the relevant research literature of the EU notified body and the laws and regulations promulgated by the EU, and systematic analysis.

Results: In the introduction of third-party agencies to assist post-market supervision of medical devices, the Chinese government still has problems such as lack of relevant laws and regulations, imperfect access mechanisms for third-party agencies, imperfect supervision mechanisms, and backward regulatory informatization construction.

Conclusion: Introducing third-party agencies to assist in the supervision of medical devices can effectively ease the pressure on supervision and supplement supervision resources. It is suggested that the Chinese government learn from the management experience of the EU notified bodies, improve the regulatory legal system, introduce relevant regulations, improve the access mechanism of third-party institutions, improve the supervision mechanism, strengthen the construction of supervision informatization, and build a unified supervision platform.
Development and Characterization of novel bigel of loxoprofen for topical drug delivery
Authors: Agarwal Mansi , Sachdeva Monika , Sharma Pankaj Kumar
Published: October 2022

Bigels are unique two-phase systems that have recently been presented as a structured method for active ingredient application. The purposes of the current study were to develop and characterize bigel formulations containing loxoprofen. They have the benefits of both hydrogel and organo-gel. In order to enhance penetration, pluronic lecithin was added to form the organo-gel, and HPMC was added to form the hydrogel, which properly hydrates the stratum corneum. Bigels were produced by mixing hydrogel with organo-gel in the appropriate ratio. pH, viscosity, extrudability, spreadability, and Gel-sol transition temperature were assessed for organo-gel and hydrogel. For the preparation of bigel, formulations O3 from organo-gel and H3 from hydrogel were characterized as optimum formulations. pH, viscosity, extrudability, spreadability, Gel-sol transition temperature, and other properties of the produced bigel were assessed. An 8-hour invitro drug release investigation yielded B1's results, which were 84.77%.  B2 demonstrated 92.35 % release, B3 demonstrated 99.18% release, and bigel demonstrated extended-release. Based on evaluation characteristics, formulation B3 was chosen as the optimal formulation. Loxoprofen bigel release kinetics according to the Higuchi model. You can utilize loxoprofen bigel as an extended-release system.

Keywords: Loxoprofen, (B)Bigel Pluronic F127, (O)Organo-gel, HPMC, Gel-sol, (H)Hydrogel
Histopathological Pancreas Analysis of Hylocereus polyrhizus Peel Ethanolic Extract on Alloxan Induced Diabetic Mice
Authors: Solikhah Tridiganita Intan , Wijaya Tania Anggreani , Salsabila , , Pavita Daffa’ Alice , Asdiyanta Amin Nur , Hamonangan Jonathan Mark
Published: October 2022

Diabetes is a metabolic disorder due to the disruption of the pancreas in producing insulin. Alloxan is a compound that has diabetogenic properties and is toxic, especially to pancreatic beta cells. When given to experimental animals, namely mice, it will cause them to become diabetic. Mice were separated into five groups consisting of 6 mice. Mice were divided into a normal control group without alloxan, a diabetic control group with alloxan, an extract treatment group of 100 mg/kg and 300mg/kg Hylocereus polyrhizus peel extract, and a positive control group with 600 μg/kg Glibenclamide. All treatments were given orally for 14 days. Neck dislocations were performed on all groups of mice on the 14th day after extract administration to retrieve pancreatic tissue. In this study, dragon fruit peel extract improved pancreatic beta cell damage compared to the diabetes control group. Giving ethanol extract of red dragon fruit peel (H. polyrhizus) can improve the histopathology of the pancreas in mice with diabetes mellitus. Ethanol extract of red dragon fruit peel (H. polyrhizus) at a dose of 300 mg/kg BW is the optimum dose for repairing pancreatic beta cell damage in mice with diabetes mellitus.

Keywords: Alloxan, Diabetes, Histopathological pancreas, Hylocereus polyrhizus peel extract, Mice
Restorasi Produk Uma Kawan: Produk Wisata Berbasis Masyarakat di Desa Baturiti Tabanan
Authors: Arcana Komang Trisna Pratiwi , Pranatayana Ida Bagus Gde , Wiyasha Ida Bagus Made
Published: October 2022

Uma Kawan merupakan salah satu wisata perdesaan berbasis masyrakat yang berlokasi di desa Baturiti Kecamatan Kerambitan Kabupaten Tabanan Bali. Produk wisata yang ditawarkan adalah swing, cycling, tracking, dan kuliner tradisional khas perdesaan oleh warga Baturiti. Pandemi Covid 19 mengakibatkan kegiatan Uma Kawan mati suri yang berakibat tidak berfungsinya fasilitas seperti swing, perlengkapan penyajian kuliner, serta sarana toilet. Dari sisi sumber daya manusia (SDM), tingkat keterampilan dan motivasi menurun drastis dan Uma Kawan tidak memiliki media untuk mengkomunikasikan produk-produknya secara elektronik. Tujuan Pengabdian Kepada Masyarakat (PKM) memberikan solusi atas masalah yang dihadapi oleh Uma Kawan dengan meningkatkan kemampuan teknis SDM di bidang pelayanan (service). Pelatihan teknis basic table set-up, penyiapan minuman sehat tanpa alkohol, penyiapan minuman kopi, pengadaan sign board, dan mengelola web adalah solusi yang ditawarkan dengan tetap menjalankan protokol kesehatan. Kegiatan Pengabdian Kepada Masyarakat (PKM) di Uma Kawan Desa Baturiti Tabanan dilaksanakan dalam bentuk pelatihan secara langsung melalui demonstrasi dan praktik. Peserta pelatihan dalam PKM ini adalah 10 orang masyarakat desa yang dipilih secara purposive ikut sebagai pengelola produk wisata Uma Kawan. Dengan pelatihan ini diharapkan Uma Kawan memiliki standar mutu layanan serta produk yang ditawarkan sesuai dengan segmen pasarnya yaitu individu yang mencari kesehatan (health seeking) melalui kegiatan cycling dan tracking di lingkungan alam pedesaan. Hasil dari pelatihan ini bahwa peserta telah menguasai dengan baik materi yang diberikan serta siap untuk diterapkan saat Uma Kawan beroperasi kembali.
SADARI: Upaya Mencegah Kanker Payudara Pada Usia Remaja
Authors: Marthasari Ni Ketut Putri , Ariana Putu Agus , Pratama Agus Ari , Aryawan Kadek Yudi , Heri Mochamad
Published: October 2022

Kanker payudara merupakan salah satu penyakit umum pada wanita dan dapat meenyebabkan kematian. Penyakit ini biasanya muncul di negara-negara dengan pendapatan rendah dan menengah dengan kebanyakan diagnosis penyakit ini yaitu pada studium lanjut. Kanker payudara saat ini merupakan jenis kanker yang paling mendominasi di Indonesia. Kanker payudara cenderung berdampak pada perempuan terdapat 8 sampai 10 kasus kanker payudara terjadi pada perempuan diusia dini. Indonesia yang masih menjadi negara berkembang di Asia Tenggara berada di urutan ke 8, kanker payudara juga merupakan masalah utama jenis kanker yang terbanyak diderita oleh perempuan Upaya deteksi dan skrining dini menjadi sangat penting ditengah masih ditemukannya kasus pada tahap awal. Masa remaja adalah waktu perubahan cepat yang memberikan kesempatan mengajar untuk membentuk perilaku sehat hingga dewasa. Tujuan dari pengabdian ini adalah memberikan Pendidikan Kesehatan bagi remaja putri dalam deteksi dini kanker payudara serta mengenai perawatan payudara dengan melakukan pemeriksaan payudara sendiri (SADARI) di SMAN 1 Kubutambahan. Tahap pelaksanannya adalah dengan memberikan penyuluhan dan pemeriksaan payudara sendiri (SADARI) yang dihadiri oleh 21 siswa. Kemudian tahap evaluasi dengan melihat pemahaman dan perilaku siswa dalam melaksanakan SADARI dengan memberikan pertanyaan atau timbal balik dari semua informasi yang diberikan di tahap pelaksanaan. Hasilnya bahwa seluruh siswa perempuan dapat melakukan praktik SADARI sebagai tes skrining tentang kanker payudara.
Violencia sexual infantil en el Caribe colombiano: departamentos de Córdoba y Sucre (2015)
Authors: Márquez Estrada José Wilson
Published: October 2022

El objetivo de este artículo es analizar la información relacionada con una serie de delitos de violencia sexual infantil perpetrados contra niños y niñas del Caribe colombiano, específicamente en los departamentos de Córdoba y Sucre, ocurridas en el primer semestre del 2015 y que aparecen registradas en los periódicos El Universal de Cartagena, El Meridiano de Córdoba y El Meridiano de Sucre, para identificar las características más relevantes con relación a la tipificación del delito, la conducta criminal, el contexto social, las circunstancias, la forma y el lugar en que ocurrieron los hechos. Metodología: se realizó una selección de noticias (17) de losperiódicos referenciados y, simultáneamente, se revisó información bibliográfica al respecto. Resultados: se encontró que las edades de los abusadores oscilan entre los 15 y 74 años, su ocupación es variada (conductores de transporte público, ayudantes de albañilería, agricultores y profesores). El vínculo con la víctima encontrado fue de hijastra, hija, sobrina, vecina y alumna, con edades entre 1 y 13 años. En conclusión, se muestra que el entorno familiar y vecinal es el escenario por excelencia para la comisión de este tipo de delitos, donde los menores se encuentran en condiciones vulnerables ante los depredadores sexuales.
Latviešu valodas dialektu atlants. Morfoloģija II. Sintakse
Authors:   Latvijas Universitātes Latviešu valodas institūts
Published: October 2022

The Atlas of the Latvian Dialects. Morphology II. Syntax was developed at the Institute of Latvian Language, University of Latvia, within the Latvian Research Council funded project No lzp-2018/1-0213 "A new approach to Latvian geolinguistic research: open data". It includes 110 Latvian geolinguistic maps and their commentaries, as well as summaries of the commentaries in English. This volume maps of this volume reflects different dialectal forms of the verb and some adverbs. Since a separate syntax volume is not foreseen, this volume also contains 12 syntax maps reflecting the most characteristic syntactic constructions of the dialects. For the convenience of the readers The Atlas of the Latvian Dialects. Morphology II. Syntax also contains maps of Latvian dialects and intonations, as well as a description of the principles of phonetic transcription, maps and commentaries, phonetic transcription, sources and literature used, as well as a network of dialects and an alphabetical list of dialects in the The Atlas of the Latvian Dialects. Maps and commentaries are developed by Ineta Kurzemniece, Liene Markus-Narvila, Anna Vulāne, Anna Stafecka (also scientific supervisor of the work). The electronic version of the maps has been prepared and updated by Anete Daina, Elizabete Laura Punka and Liene Markus-Narvila. Anete Daina, Daira Vēvere contributed to the technical preparation of the work.
MEDIATION AS A WAY TO SETTLE DISPUTES: THE HISTORICAL ASPECT OF THE DEVELOPMENT OF THE LEGAL INSTITUTION
Authors:   Ростовский государственный экономический университет (РИНХ), Ростов-на-Дону, Россия, Евгения Борисовна Паравай , Наталья Владимировна Федоренко ,   Ростовский государственный экономический университет (РИНХ), Ростов-на-Дону, Россия, Татьяна Гайковна Чебоньян ,   Ростовский государственный экономический университет (РИНХ), Ростов-на-Дону, Россия,   Ростовский филиал Российского государственного университета правосудия, Ростов-на-Дону, Россия
Published: October 2022

The importance and relevance of studying the features of the legal regulation of mediation, including the norms governing civil and commercial relations, should be investigated, due to the fact that there is a constant need for participants in civil turnover to ensure their own rights and legal interests.
ON THE NEED TO TIGHTEN THE LEGAL RESPONSIBILITY FOR PROSTITUTION
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Евгений Владимирович Миллеров ,   Донской государственный технический университет, Ростов-на-Дону, Россия
Published: October 2022

This article discusses the issues of legal struggle against prostitution as an antisocial phenomenon, in particular, the features and dimensions of administrative punishment for prostitution. Statistical data on the revealed facts of prostitution in Russia are analyzed with a comparison of these data with other illegal acts related to prostitution (both administrative offenses and crimes). The conclusion is made about the excessive leniency of administrative punishment for prostitution, the tightening of administrative punishment is proposed, as well as the establishment of criminal liability for prostitution by a person who continues to engage in prostitution during the period during which he is considered to be subjected to administrative punishment for a similar act, that is, the author proposes to introduce into the Criminal Code of the Russian Federation such a corpus delicti with the presence of there are administrative prejudices in it.
SOME ISSUES OF THE IMPLEMENTATION OF THE POLICY OF "MOUNTAIN EXPANSION" OF THE OFFICIAL AUTHORITIES IN THE NORTH-EASTERN CAUCASUS IN THE 20-50 YEARS OF THE XIX CENTURY
Authors:   Дагестанский государственный университет, Махачкала, Республика Дагестан, Россия, Магомед Баширович Магомедов
Published: October 2022

The article is devoted to the actual and little-studied problem of the page of the historical and legal aspect of the implementation of the policy of "Mountain expansion" of the official authorities in the North-Eastern Caucasus in the 20-50 years of the XIX century. The nature of the coverage in historiography and sources and the memories of the participants of the events of both sides, as well as the periods of the development of the Russian state, are investigated. The variable nature of the events of the North-Eastern Caucasus in the 20-50 years of the XIX century is indicated. The issue and policy of the "Mountain expansion" of the official authorities are revealed.
SCIENTIFIC AND METHODOLOGICAL RECOMMENDATIONS ON LEGAL REGISTRATION OF POWERS, FUNCTIONS AND SERVICES CARRIED OUT BY INDUSTRY (FUNCTIONAL) AND TERRITORIAL BODIES OF LOCAL SELF-GOVERNMENT
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Василий Владимирович Рудой , Юрий Николаевич Радачинский ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия
Published: October 2022

In accordance with the initial prerequisites of scientific research, the authors of this work proposed an original approach to the definition and relationship of the concepts of "state (municipal) authority" and "state (municipal) function". In order to increase the efficiency of organizing the activities of sectoral (functional) and territorial bodies of local self-government, the article describes the techniques of legal qualification, systematization and registration of state (municipal) powers, functions and services.
Comparing directions of Acropora coral adaptive response to environmental gradients
Authors: Beskid Sofia , Matz Mikhail
Published: October 2022

As climate change progresses, reef-building corals face multiple
environmental stressors that they must adapt to. Can corals adapt to all
these stressors at the same time, or would some adaptations exclude
others (i.e., a genetic tradeoff)? Here, we reanalyzed RNA-seq and
Tag-seq data from four studies that compared gene expression in corals
from tidal pools of different daily heat stress levels, with varying
proximity to a CO seep, containing different kinds of
algal symbionts, and separated by 15 degrees of latitude. We computed
both the genetic divergence (F) and log-fold
expression change per gene for each contrast, and then compared these
results to see whether the same genes were involved in adaptation and/or
acclimatization to different environmental gradients. We find that
genetic divergence patterns are entirely independent from each other
(with the exception of just two shared F
outliers between the two cases of CO adaptation), while
at the gene expression level there is significant overlap in up- and
down-regulated genes among multiple environmental contrasts. These
results suggest that coral populations maximize their local fitness
predominantly via gene expression plasticity (involving similar
pathways) rather than through selection-driven genetic divergence.
Still, there remains the possibility of highly polygenic adaptation with
extensive redundancy (many alternative genetic ways to achieve the same
phenotype). Regardless of the mechanism, the overall lack of tradeoffs
that we observed here suggests that corals have substantial capacity to
withstand multiple simultaneous stressors.
Development of an efficient method for selection of stable cell pools for protein expression and surface display with Expi293F cells
Authors: Chen Chuan , Wang Zening , Sun Zehua , Li Wei , Dimitrov Dimiter S.
Published: October 2022

Compare with transient expression, stable cell lines generally have
higher productivity and better quality for protein expression. However,
selection of stable cell line is time-consuming and laborious. Here we
describe an optimized selection method to achieve high-efficient stable
cell pools with Expi293F suspension cells. This method only takes two to
three weeks to generate stable cell pools with 2- to 10-fold higher
productivity than transient gene expression (TGE). In fed-batch culture
with Yeastolate, > 1 g/L yield was achieved with our
KTN0239-IgG stable cell pool in shaker ﬂasks. This method can be also
applied to efficiently display proteins on the cell surface.
Behavior and failure tracking of structural elements using applied element method
Authors: BADAWY Mahmoud Mohamed , MUSTAFA Suzan Ali A. , BAKRY Atef Eraky
Published: October 2022

Applied element method (AEM) is a recently displacement-based structural analysis method. It provides the benefits of both the finite element method (FEM) and the discrete element method (DEM). This method relies on those structures are segmented into rigid elements linked by normal and shear springs. In this paper a brief note of the AEM is given. Then, using the AEM, a 2D MATLAB open source program was created to analyze different structures with varied boundary conditions and to permit researchers for enhancing the method. The proposed program was verified using linear elastic analysis and large deformation static analysis. The influence of element size and the number of connecting springs between elements was studied. Finally, the proposed program was capable of tracking failed elements and their spread. In addition, the program could predict deflection values and structure deformed shape.