bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a Universal Multi-Epitope Vaccine Candidate against Streptococcus suis Infections Using Immunoinformatics Approaches
Authors: Zhang Yumin , Zhao Guoqing , Xiong Yangjing , Li Feiyu , Chen Yifan , Cheng Yuqiang , Ma Jingjiao , Wang Henan , Yan Yaxian , Wang Zhaofei , Sun Jianhe
Published: May 2023

Streptococcus suis is a significant zoonotic pathogen that is a great threat not only to the swine industry but also to human health, causing arthritis, meningitis, and even streptococcal toxic shock-like syndrome. Owing to its many serotypes and high geographic variability, an efficacious cross-protective S. suis vaccine is not readily available. Therefore, this study aimed to design a universal multi-epitope vaccine (MVHP6) that involved three highly immunogenic proteins of S. suis, namely, the surface antigen containing a glycosaminoglycan binding domain (HP0197), endopeptidase (PepO), and 6-phosphogluconate dehydrogenase (6PGD). Forecasted T-cell and B-cell epitopes with high antigenic properties and a suitable adjuvant were linked to construct a multi-epitope vaccine. In silico analysis showed that the selected epitopes were conserved in highly susceptible serotypes for humans. Thereafter, we evaluated the different parameters of MVHP6 and showed that MVHP6 was highly antigenic, non-toxic, and non-allergenic. To verify whether the vaccine could display appropriate epitopes and maintain high stability, the MVHP6 tertiary structure was modeled, refined, and validated. Molecular docking studies revealed a strong binding interaction between the vaccine and the toll-like receptor (TLR4), whereas molecular dynamics simulations demonstrated the vaccine’s compatibility, binding stability, and structural compactness. Moreover, the in silico analysis showed that MVHP6 could evoke strong immune responses and enable worldwide population coverage. Moreover, MVHP6 was cloned into the pET28a (+) vector in silico to ensure the credibility, validation, and proper expression of the vaccine construct. The findings suggested that the proposed multi-epitope vaccine can provide cross-protection against S. suis infections.
Comprehensive Monitoring and Ecological Risk Assessment of Heavy Metals in Soil and Surface Water of Chishui River Basin in Upper Reaches of the Yangtze River
Authors: Chen Ziwan , Xu Jing , Yang Fan , Hou Zhaolei , Ren Kun , Yu Linsong , Yang Shuyun , Li Zhong , Zhang Xiaobing
Published: May 2023

Chishui River is an important ecological security barrier area in the upper reaches of the Yangtze River in China. Therefore, it is of great significance to conduct research on soil and water ecological risks in the Chishui River basin. In this paper, the risk of heavy metals pollution and its control factors was evaluated systematically by using surface water and soil samples from 16 tributaries in the Yunnan section of the Chishui River basin. The method of soil environmental capacity and ecological risk index were studied. The results showed that the average concentration of heavy metals in the surface water of the main stream was in the order of Fe > Mn > Zn > Cu > Pb > Cd > Hg. Except for Hg, all the concentrations of heavy metals were far lower than the Class I water limits in the Environmental Quality Standards for Surface Water (GB3838-2002) issued by the Ministry of Ecology and Environment, PRC. The average concentration of Hg concentration was 0.056 μg·L−1, which was slightly higher than the limit value of Class II. Heavy metals in the surface water were distributed in a point-like manner in the main stream of the Chishui River, which was mainly affected by mining drainage, township sewage, and human production activities. Meanwhile, the environmental capacity study showed that the heavy metals in soil were in the order of Zn > Pb > Cr > Ni > As > Hg > Cu > Cd, and the environmental capacity were significant differences among different soils: purple soil > limestone soil > loess > yellow-brown soil. Soil Cd tended to migrate out of the soil under the control of the occurrence form, vegetation coverage, and human production activities, while Cr, Cu, and Ni tended to accumulate in the soil. The average comprehensive ecological risk index (RI) of heavy metals in all tributaries ranged from 44.86 to 154.15, mainly distributed in medium and low ecological risk. Therefore, it is recommended to dynamically monitor and control these pollution points in the Chishui River basin to prevent the risk of heavy metals from escalating.
Hydraulic Planning in Insular Urban Territories: The Case of Madeira Island—São João Stream, Funchal, Portugal
Authors: Lousada Sérgio , Alves Raul , Fernandes Mário , Gonçalves Leonardo
Published: May 2023

This study’s primary goal was to conduct an analysis regarding the flood susceptibility of the main watercourse of the São João (Funchal) drainage basin. In addition, if proven necessary, we also aimed to suggest mitigation measures, such as sizing a detention basin and promoting adjustments of the riverbed’s roughness coefficient. This study also resorted to geomorphological data—obtained during the watershed characterization process—that were then utilized in the SIG ArcGIS software, in order to estimate the expected peak flow rate, considering a return period of 100 years using the Gumbel distribution. Finally, the Manning–Strickler equation was utilized to determine the river discharge point’s drainage capacity; the reason for that was to verify whether its drainage capacity was sufficient to drain the entire volume of rainwater associated with an extreme flood event. In summary, the results obtained by this study indicate that the drainage capacity of the river discharge point of the São João watershed (Funchal) is insufficient when considering an extreme flood event, for a return period of 100 years. Hence, it became necessary to explore the two aforementioned mitigation measures: first, regarding the detention basin, its sizing was calculated through both the Dutch method and the simplified triangular hydrograph method; second, aiming to increase the drainage capacity of the river discharge point, it is suggested that the roughness coefficient should also be modified.
Comparative Study on the Organic Solvent of IrO2–Ionomer Inks used for Spray Coating of Anode for Proton Exchange Membrane Water Electrolysis
Authors: Jung Hye Young , Jun Yongseok , Lee Kwan-Young , Park Hyun S. , Cho Sung Ki , Jang Jong Hyun
Published: May 2023

Currently, spray coating has attracted interest in the mass production of anode catalyst layers for proton exchange membrane water electrolysis (PEMWE). The solvent in the spray ink is a critical factor for the catalyst dispersion in ink, the microstructure of the catalyst layer, and the PEMWE performance. Herein, various pure organic solvents were examined as a substitute for conventional isopropanol-deionized water (IPA-DIW) mixture for ink solvent. Among the polar solvents that exhibited better IrO2 dispersion over nonpolar solvents, 2-butanol (2-BuOH) was selected as a suitable candidate. The PEMWE single cells were fabricated using 2-BuOH at various ionomer contents, spray nozzle types, and drying temperatures, and their performance was compared to the cells fabricated using a conventional IPA-DIW mixture. The PEMWE single cells with 2-BuOH solvent showed good performances comparable to the conventional IPA-DIW mixture case and highly durable performances under accelerated degradation tests.
PENERAPAN CYBER CITY: TINGKAT KETERCAPAIAN DAN PENILAIAN MASYARAKAT DI KOTA CIMAHI
Authors: Saputra Isro , Munggaran Anugrah F.R.
Published: May 2023

ABSTRAK

Kota Cimahi memiliki permasalahan pada keterbatasan lahan untuk pengembangan kota, namun di sisi lain Kota Cimahi memiliki potensi sumber daya manusia (SDM) yang dapat mendorong Kota Cimahi untuk melakukan pengembangan dan penguasaan teknologi informasi dan komunikasi. Salah satu pengembangan yang dilakukan Kota Cimahi yaitu dengan menerapkan konsep cyber city, namun belum diketahui bentuk implementasi dan sosialisasinya terhadap masyarakat, serta belum diketahui bagaimana pencapaian dari konsep cyber city itu sendiri. Penelitian ini dilakukan untuk mengetahui tingkat ketercapaian dan penilaian masyarakat terhadap penerapan cyber city di Kota Cimahi. Analisis data dilakukan dengan metode deskriptif kualitatif dan kuantitatif, untuk mengetahui persepsi masyarakat (skala likert) dan hubungan (crosstab dan chi-square). Berdasarkan hasil analisis, diketahui bahwa konsep cyber city sudah tercapai dan persepsi masyarakat terhadap penerapan konsep cyber city saat ini sudah baik. Karakteristik masyarakat yang memiliki hubungan paling banyak dengan penilaian masyarakat tentang indikator dari variabel cyber city adalah komposisi tempat tinggal. Posisi tinggal masyarakat menentukan persepsi dan kecenderungan penilaian mereka terhadap indikator dan variabel cyber city.

       

Kata Kunci: Cyber City, Teknologi Informasi dan Komunikasi, Pelayanan Publik
Sémantique historique et cognition
Authors: Bischofsberger Marco
Published: May 2023

Le "socio-cognitivisme" conçoit l'activité cognitive comme activité de constmction inter homines, comme un ensemble d'actes interprétatifs conditionnés par les présupposés sociaux et par les points de vue adoptés par les sujets. Il rejoint ainsi les bases épistémologiques de la sémantique diachronique qui se propose de saisir le sens des mots "dans le temps", en les insérant dans le contexte culturel et social qui contribue à leur définition et à leur interprétation. Si l'on réunit les deux approches, l'unité lexicale et surtout son aspect sémantique deviennent la trace d'une opération cognitive, le résultat non pas d’une lecture, mais d'une écriture de la réalité. En adoptant une perspective radicalement constmctiviste, on discutera ensuite de la naissance de "sémantiques particulières" et des conséquences de l'hétérogénéité sociale et culturelle de la communication.
Qui lemmatise dilemme attise
Authors: Brunet Etienne
Published: May 2023

Après trente ans de controverses, le débat sur la lemmatisation s'apaise au moment où les programmes d'étiquetage et de codage grammatical sont enfin sur le marché. On s'emploie ici à comparer les résultats qu'on obtient pour un même corpus en traitant successivement les formes brutes, puis les données étiquetées, puis les lemmes dûment reconnus. Sur des données empruntées à des sources variées (programme Francil, monographie de Le Clézio, littérature latine recensée au LASLA), l'expérimentation montre que les méthodes se rejoignent lorsque la totalité du vocabulaire est prise en compte, notamment dans la mesure de la distance lexicale. Mais lorsque l'étude porte sur des distributions particulières, les données lemmatisées offrent une garantie supérieure.
La préposition de/du «complément d’agent» des verbes psychologiques causatifs : un génitif
Authors: Martin Fabienne
Published: May 2023

Cet article porte sur l’alternance prépositionnelle des prépositions de et par dans les phrases passives comprenant un prédicat psychologique causatif (type enchanter, ou étonner/ On propose d’analyser la préposition de dans cette structure comme une variété de génitif, tel que le définit Nikiforidou, 1991. Cette hypothèse permet d’expliquer les différences sémantiques générées par l’alternance des prépositions de et par, et prédit certaines contraintes sémantiques pesant sur l’adjonction d’un de-objet. On défend ainsi l’idée que le de-objet ne s 'utilise qu ’à condition que l’on puisse concevoir

1. qu’il existe une relation d’appartenance entre l’Expérient (sujet) et le référent du complément prépositionnel,

2. que l’objet cause l'émotion en fonction de cette relation d’appartenance. On montre ainsi que l’objet et la cause de l’état psychologique diffèrent selon la préposition choisie, et, corrélativement, que les énoncés à de-et à par-objet n ’ ont pas les mêmes conditions de vérité.
Quantification et focalisation en hongrois
Authors: Gécseg Zsuzsanna
Published: May 2023

En hongrois, la notion de focus est syntaxiquement contrainte : elle correspond à une position bien déterminée qui peut être occupée par certains types de SN (comme les SN définis ou ceux qui comportent un article indéfini ou un adjectif cardinal) alors que d’autres (comme les SN comportant un quantifieur universel) en sont toujours exclus. Cette étude, réalisée dans le cadre de la Théorie des Quantifieurs Généralisés et de la Sémantique des Alternatives, cherche à relier ces contraintes syntaxiques aux propriétés référentielles des SN en question. Les analyses sont fondées avant tout sur les propriétés de monotonie de la fonction dénotée par le SN et sur l’aptitude de ce SN à impliquer un contraste dans un contexte déterminé. L ’étude démontre que les SN dénotant des quantifieurs généralisés monotones décroissants ou non monotones sont toujours susceptibles d’impliquer un contraste réel, ils peuvent donc être focalisés alors que certains SN dénotant des quantifieurs généralisés monotones croissants n 'impliquent jamais un contraste réel, par conséquent, ils n ’apparaissent jamais dans la position du focus.
La grammaticalisation d’un déterminant indéfini : quelque en Moyen-Français
Authors: Combettes Bernard
Published: May 2023

In this paper, we study the process of grammaticalization that leads to the creation of the French indefinite determinant quelque(s). By considering essentially the periods of former and average French, we examine the way the correlative expression quel... que, which is a concession marker, specializes itself little by little in uses where it expresses the indermination of the referent. The reanalyse process, constitutive of the grammaticalization, is supported by particular contexts : negative, hypothetical, interrogative, injunctive, or, more largely, related to future contexts. An important moment in this evolution is constituted by the passage of the indefinite non specific value to the specific value in contexts of perception predicates.
Quantité et qualité dans les pléonasmes : le rôle des adjectifs
Authors: Biermann Fischer Michèle
Published: May 2023

How but also why tie up pleonasms with semantic universals as quantification and qualification ? By showing that in structures containing sequences of the type Noun + attributive adjective (“adjectif épithète” in French), the latter ensures completely its semantic function : either by quantifying with an intensive value, either by simply characterizing the Noun, rather from the speaker’s standpoint and not by its notional content, either again by identifying a part of the entire “Time” set. Thus, adjectives are efficient in descriptions and they depict the speaker’s conception of the “objective” reality. Pleonasms relate the world, indeed in a different manner, but they do not relate tautology
L’anaphore lexicale démonstrative dans les langues endo-et exocentriques : langue, texte, discours
Authors: Lundquist Lita
Published: May 2023

The present article studies the use of demonstrative NP anaphors, demN, in a corpus of French and Norwegian texts belonging to the domain of scientific economic discourse. The introduction of the concept of discourse makes it possible to enlarge the traditional lexical and syntactic perspective in order to evaluate to what degree differences between the uses of demN in the two corpuses of texts can be explained by linguistic and/or discursive factors. Among the linguistic factors is the tendency in French , and romance languages in general, to lexicalisé nouns, and hence anaphors, at a more specific level than Norwegian, i.e., Germanic languages, and also the preference for hierarchical, hypotactic presentation of information in desententialised constructions in French as compared to linear, paratactic ordering in Norwegian, which has an impact on the number of realised syntactic subjects.
L’anaphore selon ledit N : propriétés et fonctionnement d’une expression anaphorique particulière
Authors: Theissen Anne
Published: May 2023

The aim of this article is to point out the function of a specific French anaphor at which linguists have not paid much attention : ledit N. We will first try to describe its properties and then, we will explain its characteristics based on its sense. By this way, the originality of the expression will appear not only in its properties but also in its functions.
Sur quelques caractéristiques des noms sous-spécifiés
Authors: Legallois Dominique
Published: May 2023

Après avoir relevé l'ensemble des noms sous-spécifiés (les noms intégrant la construction Nss Être QUE P \ de inf.) d'un corpus, nous intéressons aux notions de spécification et de sous-spécification, en montrant un double mouvement : le Nss catégorise un contenu propositionnel, alors que ce dernier apporte une détermination au nom. Nous examinons ensuite la nature syncatégorématique de ces noms, nature rappelant sur certains points celle des noms employés métaphoriquement. Nous remarquons également que les Nss sont des indices de rationalité des discours et que la construction spécificationnelle peut être comprise comme une métaphore grammaticale, au sens de M. Halliday.
Evolution de la locution adverbiale d'une certaine manière : des emplois adverbiaux verbaux aux emplois modaux
Authors: Schnedecker Catherine
Published: May 2023

Cette contribution distingue deux emplois de la locution d’une certaine manière, appuyés sur des critères syntaxiques et sémantiques : l’un où elle est régie par le verbe et conditionnée par son sémantisme (verbe non statif, dénotant un procès évaluable) et sa morphologie (préférence pour les formes non finies) ; l’autre où elle joue le rôle d’un adverbial modal, portant soit sur un constituant de l’énoncé, dont elle dénonce la formulation inadéquate, soit sur son ensemble, présenté comme un jugement de valeur du locuteur, dont les fondements restent «vagues».

Les liens et corrélations entre ces deux emplois sont analysés dans une perspective diachronique sur une période de trois siècles. Nos observations entérinent le processus d’évolution mis au jour par E. C. Traugott, à savoir le passage d’un adverbial aidant à spécifier les modalités de l’action dénotée par le verbe - ce qui correspond à la fonction dite référentielle -à une forme permettant au locuteur de moduler la vérité de son propos - ce qui correspond à la fonction dite expressive. Cette évolution est d’ailleurs doublement facilitée par le caractère abstrait du N de manière, et par le sémantisme de certain, qui, nous en faisons l’hypothèse, est une sorte d’adjectif «hyperonyme».
Remarques sur la sémantique du nom espace
Authors: Kleiber Georges
Published: May 2023

The aim of this paper is to analyze several semantic contents of the noun space. The opposition 'abstract/concrete' points out the immateriality and the visual accessibility of the entities denoted by the noun space. These two features will allow us to solve the paradox of "visibility" - How is it possible to see immaterial entities ?
La normalisation industrielle en traduction : normalisateurs contre formateurs ?
Authors: Barabé Donald , Brunette Louise
Published: May 2023

La traduction est une industrie et s'affirme comme telle. Cependant, elle a du mal à suivre la voie de la normalisation industrielle dans laquelle les autres secteurs se sont résolument engagés. Nous considérons qu'elle se doit de réagir, et massivement, pour empêcher que le domaine ne se trouve envahi par le charlatanisme. C'est la qualité du produit et la crédibilité de l'industrie qui en dépendent. Mais comment intéresser les acteurs de la traduction aux normes ? À notre avis, cette tâche revient naturellement aux universités qui forment les futurs professionnels. Il ne s'agit pas de leur faire ingurgiter de la matière, mais de leur faire prendre conscience qu'industrie et profession ne s'opposent pas, mais vont de pair.
Ways of managing the dynamics of terminology in multilingual communication
Authors: Temmerman Rita
Published: May 2023

We point out a number of the parameters influencing the dynamics of understanding and the role of terminological variation therein, starting from a case study in the domain of invasion ecology. Over the past fifty years invasion ecology research has been conducted within a wider social milieu of contentious values and politics. Controversy and disagreements have created an intellectually dynamic and emotionally charged atmosphere among researchers. They have often resorted to evocative language and imagery in their English language articles and this has for instance resulted in the coining of metaphorically motivated terminology. An attempt is made to open up the issue of societal dynamics to the European multilingual reality as we tentatively investigate what happens to metaphorical and evocative language in translated texts (French and Dutch) on invasion ecology.
À la recherche du complément de manière prototypique
Authors: Stosic Dejan
Published: May 2023

Adverbs are traditionally considered to be the best representatives of manner adjuncts. However, this hypothesis is only based on intuition and has never been proven in any statistical framework. An in-depth analysis of some 850 manner adjuncts, identified by using both syntactic and semantic criteria in J.M.G. Le Clézio's novel Étoile errante, allows us to verify this hypothesis on the one hand, and on the other to establish quantified relationships between different types of syntactic constituents capable of functioning as manner adjuncts. Our results suggest that, if adverbs do appear to be the most frequent type of manner adjuncts in the corpus, other linguistic features show that they fall far short of being representative of the behaviour of all adjuncts expressing manner.
Emerging Therapies and Advances in Sickle Cell Disease with a Focus on Renal Manifestations
Authors: Obadina Mofiyin , Wilson Sam , Derebail Vimal K. , Little Jane
Published: May 2023

The underlying mechanisms of disease in sickle cell disease (SCD) contribute to a multifaceted nephropathy, commonly manifested as albuminuria. In severe SCD genotypes (e.g., Hemoglobin SS [HbSS]), albuminuria and CKD are major predictors of mortality in this population. Therefore, the monitoring and management of renal function is an intrinsic part of comprehensive care in SCD. Management of nephropathy in SCD can be accomplished with SCD-directed therapies and/or CKD-directed therapies. In the past 5 years, novel disease-modifying and palliative therapies have been approved in SCD to target aspects of the disease, such as anemia, inflammation, and vasculopathy. Along with conventional hydroxyurea and chronic transfusion, l-glutamine, crizanlizumab, and voxelotor have all been shown to mitigate some adverse effect of SCD, and their effect on nephropathy is being investigated. CKD-directed therapies such as renin–angiotensin–aldosterone system blockers have long been used in SCD nephropathy; however, more complete long-term studies on benefits are needed. Given the effect of renal disease on survival, further assessment of the mechanisms and efficacy of these SCD-directed or CKD-directed therapeutic agents is essential.
EFFECT OF PROPOLIS ON WOUND HEALING: A CLINICAL AND HISTOMORPHOMETRIC STUDY IN RATS
Authors: AKPINAR Aysun , ÖZDEMİR Hakan
Published: May 2023

Background: Propolis is known to have antioxidant, antiinflammatory, antibacterial, antiviral, immunostimulant and local anesthetic effects. The aim of the present study was to investigate the clinical and histomorphometric effects of propolis on the healing of excisional palatal wounds in rats.

Materials and methods: Sixty male Wistar rats were used for the study. Six animals were sacriﬁced at beginning of the study as initial wound (0 day). The rats were divided into three groups: Propolis (P), Chlorhexidine (CHX) and Control (C). Subjects in all three groups were randomly selected to form nine subgroups of six rats each. Under anesthesia, circular excision wounds with a diameter of 3 mm were formed in the middle of the palate of the rats by punching. The mucoperiosteal part was removed with sharp dissection, and the area on the open bone surface was left to heal the secondary wound. Propolis was administered locally at a rate of 1 ml/day. The rats were sacriﬁced on days 7, 14, and 21, and pictures of the wound area were taken. Each photograph was transferred to a dedicated program to measure the defect area. Histological sections were taken and the presence of inﬂammatory cells, epithelialization, and degree of healing were assessed.

Results: The average wound area between epithelial margins decreased signiﬁcantly over time in all groups (p
On the Solution of Mathematical Model Including Space-Time Fractional Diffusion Equation in Conformable Derivative, Via Weighted Inner Product
Authors: ÇETİNKAYA Süleyman , DEMİR Ali
Published: May 2023

This research aims to accomplish an analytic solution to mathematical models involving space-time fractional differential equations in the conformable sense in series form through the weighted inner product and separation of variables method. The main advantage of this method is that various linear problems of any kind of differential equations can be solved by using this method. First, the corresponding eigenfunctions are established by solving the Sturm-Liouville eigenvalue problem. Secondly, the coefficients of the eigenfunctions are determined by employing weighted inner product and initial condition. Thirdly, the analytic solution to the problem is constructed in the series form. Finally, an illustrative example is presented to show how this method is implemented for fractional problems and exhibit its effectiveness and accuracy.
Finite Element Modeling of a Stone Layer Under a Strip Footing to Estimate Soil Behavior and Determine Optimal Stone Layer Width and Depth
Authors: KARIMI GHALEHJOUGH Babak
Published: May 2023

Various methods can be applied to improve soil behavior in order to increase the bearing capacity or reduce the settlement of footings. These methods can be categorized as stabilization or improvement of soil by use of different geosynthetics; injection methods; grouting or replacing weak soil with stronger materials. One of the most common methods and materials that can be used for improving soils, is placing a stone layer under the footing. In this study, a stone layer under a strip footing is simulated with the finite element method (FEM) to estimate the soil behavior in different conditions. A strip footing with a width of 1m and length of 8m with a 100 kN/m2 uniform load was modelled. Different widths of stone layer from 1B to 3B (B was the strip footing width) with different depths of 0.5B, 1B, 1.5B, and 2B were modelled in Plaxis 3D and results were obtained from the simulation. By reviewing the results, it was found that the optimum dimensions of the stone layer to place under the presented strip footing was 2B width and 1B depth. This result can be applied to real projects with similar conditions.
Independent and Combined Associations of Sleep Duration, Bedtime, and Polygenic Risk Score with the Risk of Hearing Loss among Middle-Aged and Old Chinese: The Dongfeng–Tongji Cohort Study
Authors: Liu Miao , Zhang Haiqing , Wang Zhichao , Mo Tingting , Lai Xuefeng , He Yaling , Jiang Minghui , He Meian , Kong Weijia , Wu Tangchun , Zhang Xiaomin
Published: May 2023

Evidence available on the independent and combined associations of sleep duration, bedtime, and genetic predisposition with hearing loss was lacking. The present study included 15,827 participants from the Dongfeng–Tongji cohort study. Genetic risk was characterized by polygenic risk score (PRS) based on 37 genetic loci related to hearing loss. We conducted multivariate logistic regression models to assess the odds ratio (OR) for hearing loss with sleep duration and bedtime, as well as the joint association and interaction with PRS. Results showed that hearing loss was independently associated with sleeping ≥9 h/night compared to the recommended 7 to <8 h/night, and with bedtime ≤9:00 p.m. and >9:00 p.m. to 10:00 p.m. compared to those with bedtime >10:00 p.m. to 11:00 p.m., with estimated ORs of 1.25, 1.27, and 1.16, respectively. Meanwhile, the risk of hearing loss increased by 29% for each 5-risk allele increment of PRS. More importantly, joint analyses showed that the risk of hearing loss was 2-fold in sleep duration ≥9 h/night and high PRS, and 2.18-fold in bedtime ≤9:00 p.m. and high PRS. With significant joint effects of sleep duration and bedtime on hearing loss, we found an interaction of sleep duration with PRS in those with early bedtime and an interaction of bedtime with PRS in those with long sleep duration on hearing loss (
P
int
<0.05), and such relationships were more evident in high PRS. Similarly, the above relationships were also observed for age-related hearing loss and noise-induced hearing loss, particularly the latter. In addition, age-modified effects of sleep patterns on hearing loss were likewise observed, with stronger estimation among those aged <65 years. Accordingly, longer sleep duration, early bedtime, and high PRS were independently and jointly related to increased risk of hearing loss, suggesting the importance of considering both genetics and sleep pattern for risk assessment of hearing loss.
Pengaruh Prestasi Kerja Dan Pengalaman Kerja Terhadap Promosi Jabatan (Studi Kasus Pada Toyota Auto 2000 Cab. Kramat Jati)
Authors: Widodo Nico , Jaelani Achmad
Published: May 2023

Promosi Jabatan adalah salah satu cara yang dipilih untuk meningkatkan produktivitas perusahaan. Dalam pengambilan keputusan promosi jabatan ada banyak faktor yang mempengaruhi, diantaranya Prestasi Kerja dan Pengalaman Kerja. Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh prestasi kerja dan pengalaman kerja terhadap promosi jabatan di Toyota Auto 2000 cabang Kramat Jati. Sampel yang digunakan dalam penelitian ini yaitu seluruh karyawan yang berjumlah 50 karyawan. Hasil penelitian menunjukan secara parsial (uji t), Variabel prestasi kerja tidak berpengaruh positif dan signifikan terhadap variabel promosi jabatan, sedangkan variabel pengalaman kerja berpengaruh positif dan signifikan terhadap promosi jabatan di Toyota Auto 2000 cabang Kramat Jati. Selain itu hasil penelitian secara simultan (uji f) menunjukan bahwa variabel prestasi kerja dan pengalaman kerja secara bersama-sama berpengaruh positif dan signifikan terhadap promosi jabatan di Toyota Auto 2000 cabang Kramat Jati
Sustainability in Construction
Authors: STANCA Simona
Published: May 2023

The main theme of this work is the sustainability of buildings and their relevance for sustainable development in Romania and Europe in the current context of orientation towards sustainable augmentation, minimizing the negative impact on the environment.A sustainable building must be designed to use the necessary resources: energy, water, and materials in a more efficient way while aiming at reducing the impact that the construction itself has on the health of the occupants but also on the environment.As it is known, human activity in the last few centuries has led to the consumption of resources and the spread of pollutants in the environment.

According to statistics, over time it has been proven that the construction sector is one of the most  active contemporary polluters. The largest amount of greenhouse gas emissions from the building sector results from the use of energy (e.g., for heating, lighting, etc.). Thus, it is demonstrated the need to decrease energy consumption for the use of buildings, but also for their construction and recycling.
Hastaların Elektronik Sağlık Kayıt (ESK) Sistemleri için Güvenli Blok Zincir Destekli Bulut Sistemi
Authors: MIZRAK Hamit , ASLAN Serpil
Published: May 2023

Dünyada birçok işlemler artık dijitalleştiğinden dolayı veri güvenliliği, veri paylaşımı, veriye hızlı erişim, verilerin bütünlüğünü korunmak önemli görülmüştür. Her geçen gün, günlük yaşantımızda bilgisayara bağımlılığımız ve bu bağlılığa paralel olarak verilerin oluşması tamamen doğal bütünün bir parçasıdır. Oluşan bu büyük veri topluluğu beraberinde veri güvenliğinin önemini de arttırmıştır. Veri güvenli konusunda son zamanlarda en çok duyulan kelime blok zinciri kelimesidir. Blok zincir, güvenli veri paylaşımını sağlamak ve merkezi olmayan veri işlem bütünlüğünü korumak amacıyla tasarlanmış birçok bilgisayardaki işlemleri kaydeden ve daha sonra hiçbir şekilde geriye dönük olarak değiştirilemeyen halka açık dijital defterlerdir. Son yıllarda bulut tabanlı Elektronik Sağlık Kayıtları (ESK), hasta verilerine uzaktan erişim için birçok araştırmacının ilgi odağı haline gelmiştir. Hasta verilerinin doğruluğu ve gizliliği, sağlık sektöründe önemli bir endişe kaynağıdır. Bu çalışmada, ESK kayıtları için veri erişim kontrolü ve denetimi sağlarken bulut servis sağlayıcıları arasında sağlık verilerinin paylaşılması için blok zincir destekli yeni bir çözüm önerilmiştir. Önerilen yöntemle, hastanın elektronik sağlık kayıtlarının sağlık sektörü tarafından yönetilmesinden ve kontrol edilmesinden, hastaların verilerinin kontrolünde olduğu hasta merkezli bir uygulamaya geçiş hedeflenmektedir.
Optimization of Pectin Extraction from Kepok Banana Peel (Musa Acuminata Balbisiana Colla) Using Natural Deep Eutectic Solvent (NADES)
Authors: Fauzan Ahmad , Prihandini Ghusrina , Yudha W N Angga , Sihaloho Rivan
Published: May 2023

Kepok banana peel is an abundant waste used as the main ingredient in pectin extraction. The pectin contained in Kepok bananas is known to be at a fairly high level compared to other types of bananas. This study aimed to determine the water content, methoxyl content, equivalent weight, galacturonic acid, and pectin yield in the pectin extraction process using the NADESS solvent extraction method at various NADESs C molar ratios (1:4; 1:7; 1:20). ), and extraction temperature (80oC, 90oC, 100oC). based on the results obtained, the best extract located at a ratio of 1:4 with a temperature of 90oC, with a moisture content of 99.8%, methoxyl content of 2.79%, yield of pectin of 5.81%, an equivalent weight is 5333.33, and the galacturonic acid content is 75.56%. While the test results show that the concentration of the given K: G solution affects the amount of pectin yield obtained in this extraction process.
The Effect of Additional Chitosan and Cellulose on The Performance of Bioplastic from Manihot Glaziovii Starch
Authors: Dewi Andini Puspita , Mardhiyana Aqqilla , Manfaati Rintis , Leoanggraini Unung
Published: May 2023

Manihot Glaziovii has a starch content of 77.87 making it potential to be used as raw material for bioplastics manufacturing as a substitute for conventional plastics. It requires the addition of biopolymers (fillers) and plasticizers to overcome weaknesses against mechanical properties and water resistance. This study aims to determine the effect of filler variations on the quality of bioplastics to be compared with SNI No.7188.7:2016 using fillers addition in the form of chitosan and cellulose from newsprint and sorbitol as plasticizer were expected to improve the quality of the bioplastics. Melt intercalation method are used with heating temperature of 60°C-80°C for 60 minutes and stirring speed of 500 rpm. The variation of cellulose combination for 30% chitosan (w/w starch) was 10%, 12%, 14%, 16%, and 18% while the variation of chitosan for 16% cellulose (w/w starch) was 20%, 30%, 40 %, 50%, and 60%. Based on the test results, the best characteristic value for the water absorption is 120.65%, biodegradability is 32.74%, tensile strength value is 15.72 MPa, WVTR value is 6.52 g/m2.hour, and  elongation is 29.76%. From the test results, it can be concluded that bioplastics made from Manihot Glaziovii starch have not been able to meet SNI No.7188:2016.
Pro-Kontra Terjemah Tafsiriyah Al-Qur’an Bacaan Mulia Karya H.B. Jassin
Authors: Arpaja Habib
Published: May 2023

This study aims to describe the discourse on the controversial translation of the Koran Bacaan Mulia by H.B Jassin. To achieve this goal, this study uses a qualitative method with analysis using content analysis. The results of this study that the translation of the Koran H.B. Jassin is unique because it displays the aesthetics of the Qur'an which is manifested in the form of a poetic translation. This work caused a stir in the country and invited the controversy of Muslims in Indonesia. Various accusations and criticisms were directed at H.B Jassin who was considered incompatible in the field of the Qur'an because he did not master Arabic and other sciences that supported the process of translating the Qur'an. The debate about whether the Qur'an tends to be poetic or prose, long before H.B Jassin's work related to the poetry of the Qur'an appeared. The majority of scholars are of the opinion that the Qur'an without being poetic already contains elements of very great poetry. Regarding the rhyme contained in the Qur'an, not only Muslim scholars have studied it. The orientalists also discussed it, such as Richard Bell, who argued that there are hidden rhymes. Differences in understanding the verses in the Koran itself have sometimes led to pros and cons, plus there have been translations in poetic form whose content sometimes does not match the original text. Apart from that, the translation of the Qur'an H.B Jassin; The Noble Readings of the Qur'an should be appreciated because it has colored the treasures of Islamic scholarship in Indonesia as well as a form of creativity in receptive to the Qur'an.
Karapan Case in Islamic Perspective as a Madurary Cultural Identity in Pasean Pamekasan Community
Authors: Pristine Adi Depict , Nor Farida Siti
Published: May 2023

Madura is an island located in the northeast of East Java. Madura has its own unique culture, one of the cultural icons in Madura is Karapan Sapi (Kerrabhân sapè), a cow racing competition. The Karapan Sapi culture emerged from the upbringing of K Ahmad Baidlowi, the grandson of Prince Pulang Jiwo (Panembbahan Blingi), to cultivate crops as a form of gratitude to God Almighty for the abundant harvest. But today's culture is experiencing degradation and is far from Islamic elements. This research is a literature study to see how the Karapan Sapi culture is from an Islamic perspective and its relation to the identity of the island of Madura itself. From the analysis of the existing theory, it can be concluded that Karapan Sapi (Kerrabhân sapè) is a typical Madurese tradition combining folk celebrations, entertainment, livestock health performances, and cattle racing. It is called Kerapan Sapi because two pairs of bulls compete for their running speed (é kerrap). Purpose if this research is to describe the karapan case in an Islamic perspective in the 20th century and the present. This research uses a qualitative approach with descriptive type. As for analysis used is qualitative data analysis which consists of three stages to answer the problem studied. The degradation in implementing the Kerapan Sapi tradition is due to criminal acts or activities that lead to things contrary to Islamic religious values. Torture of animals in the tradition of Karapan Sapi is the reason for the issuance of the Decree of the Governor of East Java No. 1/ins/2012 dated May 1, 2012, regarding the prohibition of bull racing with violence. The revitalization of Karapan Sapi's culture, which has a strong Islamic feel, takes time to implement. Law enforcement is also tricky and takes a long time to be realized. This is caused by the lack of firmness of the government and law enforcement, as well as the lack of awareness from the public.
Preparation of antireflection structures with heat resistance by nanoimprinting using anodic porous alumina molds
Authors: Yanagishita Takashi , Ooe Ryoga , Ishibashi Yuki , Mitsuru Tomonori
Published: May 2023

Polysiloxane antireflective structures composed of tapered nanopillar arrays were prepared by nanoimprinting using anodic porous alumina molds with tapered pores. Because polysiloxane is a heat-resistant material, the resulting tapered nanopillar array structures were maintained even after heat treatment at 200 °C. In addition, no significant changes in antireflection properties were observed before and after heat treatment at 200 °C. These results indicate that the polysiloxane nanopillar arrays obtained in this study can be applied as heat-resistance antireflection structures.
KOMUNIKASI PERSUASIF ORANG TUA DENGAN ANAK DALAM MEMBENTUK PERILAKU TAAT BERIBADAH DI DESA JATI KESUMA
Authors: Wulandari Ai Wanda , Abidin Syahrul
Published: May 2023

The phenomenon that occurs in the Jatikesuma Village community provides the background for this research, where parents use persuasive communication activities in the form of persuasion or invitations to their children, but not all parents apply it. This fact encourages the author to propose the forms of persuasive communication used by parents on their children, the obstacles faced by parents in their children, and the results achieved by parents on their children. The author used a qualitative research method by conducting field research and qualitative description, collecting qualitative data, and analyzing the data afterwards. The author collected data using observation, interviews, and documentation techniques. The results of this study are expected to provide an overview of the forms of persuasive communication used by parents on their children in the Jatikesuma Village community. The forms of child behavior in worship in Jatikesuma Village were found to be different in this study. This study identifies the forms of persuasive communication used by parents to their children in the form of persuasion or invitations, namely forcing the child, monitoring, complying with the child's wishes or providing rewards, and giving praise. This study also identifies obstacles faced by parents with their children, namely the lack of willingness from the child themselves, the child only performs worship when given a reward, the child spends too much time playing with their phone, and parents who do not care. The results achieved in this study include the increasing diligence of children in worship, the emergence of trust from parents towards their children, and the increasing willingness of children to read the Quran. The recommendations from this study include urging the village chief and religious figures to encourage the community to teach children to read the Quran and to perform prayers in congregation, urging parents to provide understanding and influence children to get used to and willing to perform worship from an early age, and urging children to perform worship and make the Quran a guide in a better life.
Analysing financial performance of listed cement industries in Nigeria: Financial Ratio Approach
Authors:   Mai Idris Alooma Polytechnic, Geidam, Yobe State, Nigeria, Olayinka Aminu Abdulrahim , Mustapha Shettima ,   Mai Idris Alooma Polytechnic, Geidam, Yobe State, Nigeria
Published: May 2023

Purpose: The grounds for this study are to reflect a quantitative connection allying the financial statements of different firms at different periods and how the financial performance (FP) of firms can be measured using financial ratios. Research methodology: This research employs descriptive research with a quantitative approach focusing on calculations. Data were analysed through the Financial Ratio Analysis (FRA). Results: The comparative FRA unlocks the overall FP of the three firms. The result refill that, on average, Dangote Cement plc maintain the lead, CCNN/BUA Cement second, while Lafarge Africa plc is the least in all the FP indicator used. Limitations: The analysis is restricted to ten years FSs published by the three giant firms in the cement industries in Nigeria plc between the years 2012 to 2021. Contribution: This analysis expatriates and, in greater detail, the benefits that can be derived from applying FR analysis as a tool for financial performance (FP) measurement. It also helps in determining how the financial performance of firms can be measured through financial ratios.
روسيا بين الاسلام والأرثوذوكس
Authors: م. ثائر غازي العاني
Published: May 2023

الحمد لله رب العالمين وأفضل الصلاة والتسليم على نبينا الأكرم محمد وعلى آلهوأصحابه ومن اهتدى بهديه الى يوم الدين.يعتبر دين الإسلام ثاني أكبر الأديان في العالم؛ ويعد ثاني دين في العالم من حيثعدد معتنقيه إذ قدر عدد المسلمين طبقاً لأبحاث منتدى ييو للدين والحياة العامة في العام(2009) 1.57 مليار نسمة بنسبة تفوق %23 لعدد السكان في العالم(!" .أهمية الموضوعتتجلى أهمية الموضوع من أن دين الإسلام يعتبر ثاني أكبر الأديان في العالمويعد ثاني دين في العالم من حيث عدد معتنقيه إذ قدر عدد المسلمين طبقاً لأبحاث منتدىبيو للدين والحياة العامة في العام (2009) 1.57 مليار نسمة بنسبة تفوق 9623 لعددالسكان في العالم( 3 حيث يتوزعالمسلمون في روسيا على 40 قومية أكبرها التترء إذ يبلغون 5 ملايين مسلم(تشكل نسبتهم حوالى %4 من السكان)؛ وهذا يعني أن التتر يحتلون المرتبة الثانية بعدالروس من حيث عدد السكان في روسيا.وكانت الكنيسة الروسية الممثلة في مجلس فلورنسا في عام 1439م من قبلالمطران ايزيدور كييفأا قد وقعوا مع الأساقفة الروس قانون الاتحاد في المجلس وأعلنوا الاتحاد ؛ والتي لاقت ترحيبا من قبل شعوبها ؛ في جميع أنحاء أراضيها أناءعودتهم إلى موسكو ثا .سبب اختيار الموضوعلما كانت المسيحية الأرثوذكسية هي الديانة التقليدية والأكثر انتشارا في روسيا فيالوقت الحالي وتعتبر جزءا من "التراث التاريخي" الروسي حسب للقانون الصادر عام
التمركز الاثني وعلاقته بالمشاركة السياسية لدى طلبة الجامعة
Authors: م.م زلزلة محمود عباس
Published: May 2023

يعد كل من التمركز الاثني والمشاركة السياسية من المتغيرات المهمة التي ظهرت

في المجتمع العراقي في الفترة التي تلت الاحتلال الامريكي عام 2003ءمن حيث تاثيرها

على الحياة الاجتماعية والسياسية للناس ولاسيما طلبة الجامعة لذا كان من الضروري

اجراء دراسة توضح العلاقة بين المتغيرين»وقد توصلت الدراسة الى نتائج التالية:-

[-يوجد لدى عينة البحث تمركزأ اثني.

2-توجد فروق ذات دلالة احصائية في التمركز الاثني تبعا لمتغير الجنس(ذكور-

اناث)ولصالح الذكور .

3-المشاركة السياسية كانت ضعيفة لدى عينة البحث.

4-توجد فروق ذات دلالة احصائية في المشاركة السياسية تبعا لمتغير الجنس( الذكور-

اناث)ولصالح الذكور .

5-توجد علاقة بين التمركز الاثني والمشاركة السياسية.

الفصل الاول

الإطار العام للبحث
اضطرابات الأكل وعلاقته بصورة الجسم لدى المراهقين
Authors: د.سعدية كريم درويش
Published: May 2023

تعددت النعوت التي وصف بها هذا العصر الذي نعيش فيه فهو عصر الالةوعصر القلق وعصر الذرة وعصر الكومبيوتر وأخر هذه النعوت وليس أقلها دلالة هوعصر الاضطرابات النفسية ث ذلك أن الانسان المعاصر قد اخذ يظهر من مظاهر السلوكوالتفكير ماله ان يكشف عن الخلل والاضطراب في حياته بقدر ماهو تعبير عن وطاةالحياة المعاصرة وصعوبة المسايرة مع متطلباتها (كمال » 1987 :98) . فضلا عن ذلك الى الظروف الاجتماعية والتربوية والاقتصادية الصعبة الناجمةعن الوضع الذي تعرض له المجتمع العراقي الذي ادى الى زيادة عدد المشكلات النفسيةوالاجتماعية والتربوية لدى شريحة واسعة من ابناء المجتمع ومنها شريحة المراهقينوعلى الرغم من انه لا توجد إحصائيات دقيقة وواضحة عن هذه المشكلات المتعددة إلاان بعض الدراسات المحلية أشارت الى شيوع بعض مظاهر اضطرابات الشخصية لدىالمراهقين. وتعد صورة الجسم (100886 8007) من المفاهيم الحيوية التي نالت اهتمامالباحثين ؛ اذ عدت بعدا من ابعاد الذات (دوجان 0 2002 : 7) . واذا كانت هناكمتغيرات متباينة سواء اكانت نفسية او بيئية خارجية تعوق قدرة الفرد على التواصلالفعال والتوافق السليم ؛ فان صورة الفرد السلبية عن جسمه او عدم رضاه عنها قد يكوناحد هذه العوامل التي تعوق التوافق مع ذاته وبيئته المحيطة به في الوقت نفسه
أثر برنامج ارشادي معرفي سلوكي في خفض التفكير الاضطهادي لدى طالبات الجامعة من المستخدمات للفيس بوك
Authors: د. زهراء عبد المهدي
Published: May 2023

استهدف البحث الحالي ما يأتي :

1. التعرف على مستوى التفكير الاضطهادي لدى طالبات جامعة بغداد من مستخدمات

 

الفيس بوك.

2. بناء برنامج إرشادي معرفي لخفض التفكير الاضطهادي لدى طالبات جامعة بغداد من

 

مستخدمات الفيس بوك.

3. التعرف على اثر البرنامج الإرشادي المعرفي في خفض التفكير الاضطهادي لدى

 

الطالبات.

وذلك من خلال التحقق من الفرضية الآتية :

 

لا توجد فروق ذات دلالة إحصائية بين متوسط درجات المجموعة التجريبية

والمجموعة الضابطة على مقياس التفكير الاضطهادي في الاختبار البعدي .

حيث يتكون مجتمع البحث من (6247) طالبة من طالبات جامعة بغداد لجميع

 

الأقسام العلمية والإنسانية/رالدراسة الصباحية وتم اختيار عينة البحث بالطريقة العشوائية

البسيطة ؛ إذ بلغت عينة البحث (120) طالبة ؛ وتم بناء مقياس للتفكير الاضطهادي ؛ وتم

استخراج الصدق الظاهري له بعد عرضه على مجموعة من الخبراء والمحكمين في

التربية وعلم النفس ؛ كذلك تم التحقق من صدق البناء وتم استخراج النبات للمقياس

بطريقة (التجزئة النصفية ؛ والفا- كرونباخ) ؛ ثم تطبيق المقياس بصيغته النهائية إذ تكون

من (54) فقرة ذات الخمس بدائل (تاتي في تفكيري باستمرار ؛ تاتي في تفكيري كثيرا 9

تاتي في تفكيري باعتدال ؛ تاتي في تفكيري قليلا ؛ لاتاتي في تفكيري) تعطى لها