bluuebunny/crossref_metadata_2025 huggingface dataset:
722 – Effect of Regular Aerobic Exercise on Depression in Postmenopausal Women
Authors: Aghamohammadi A. , Rajabi A. , Zafari M. , Aghamohammadi A.
Published: July 2013

Background and objective:

Most women that reached menopause, experience depression. This study was done with this purpose to investigate the effects of regular aerobic exercise on depression in postmenopausal women.

Methods:

In this experimental study, twenty six postmenopausal depressed women with age of 45-55 years, who sampled randomly in 2 groups (control and experimental), were participated in this investigation. The experimental group followed exercise training program including walking three times a week, for 3 months. But control group did not participate in any exercise program. depression level was measured before and after exercise.

Findings:

Mean of depression in experimental group before exercise training relative to after exercise training were significantly decreased.

Conclusion:

The results of present study demonstrated that regular aerobic exercise training decrease depression symptom. So, the authorities should apply strategies to decrease depression symptoms by changing life style from inactivity to exercise training in order to support postmenopausal women somatic health.
726 – Improvement of Obsessive-compulsive Symptoms in Schizophrenia Patients after Switching from Typical or Atypical Antipsychotics to Amisulpride
Authors: Sirota P. , Hadi E.
Published: July 2013

Background:

Obsessive-compulsive symptoms (OCSs) are frequently comorbid with schizophrenia. Various atypical antipsychotics induce OCSs by 5-HT2A receptor inhibition. Amisulpride causes only minimal inhibition of the 5-HT2A receptor, and therefore, should not induce or exacerbate OCSs in patients with schizophrenia.

Objective:

To evaluate the efficacy and tolerability of amisulpride on OCSs in patients with schizophrenia who were taking typical or atypical antipsychotics.

Method:

21 patients, aged 18-65 years, with schizophrenia and OCSs (DSM-4 criteria) with a score of 16 or higher on YBOCS and taking a single antipsychotic were enrolled to a 12-week prospective open trial of amisulpride (400-1200 mg/d). Changes in YBOCS, PANSS,CGI,GAF QLS -18, extrapyramidal symptoms, adverse events, and body-weight changes were evaluated 12 weeks after the antipsychotics were switched to amisulpride.

Results:

All 19 patients who completed the trial had an improvement on the YBOCS,PANSS,CGI,GAF AND QLS-18. At week 12,the mean YBOCS total score decreased significantly (26.579 ± 5.124 vs.14.631± 5.479; p < 0.001),the mean PANSS total score decreased significantly (83.947±17.886 vs.63.421±14.311; p < 0.001). Eight patients (42.1%) showed 50% or more improvement in the YBOCS total score. Thirteen patients (68.4%) showed 20% or greater improvement in the PANSS total score. Amisulpiride was safe and well tolerated.

Conclusions:

These results indicate that switch to amisulpiride is very effective for OCSs, psychotic symptoms and global functioning in patients with schizophrenia.However, changes in OCSs and psychotic symptoms were independent. Further studies with amisulpiride under controlled conditions are needed for these patients.
729 – Prescribing Antipsychotics in Patients with Dementia, Milton Keynes, England, UK
Authors: Al-Taiar H.
Published: July 2013

Background:

Dementia is a serious loss of global cognitive ability in a previously unimpaired person, beyond what might be expected from normal aging.

There are about 820,000 people in the UK with dementia (Alzheimer's Research Trust 2010).

Aim:

To show whether we compiled with the Department of Health in prescribing antipsychotics for dementia patients. All the patients have an indication recorded for the prescribing of antipsychotics including target symptoms.

Methods and materials:

We included all the patients with dementia who were under the care of the MCPCT Older Adult Team (Outpatients, inpatients, and memory assessment clinics) between April 1st 2011 - June 30th 2011.

Results:

Antipsychotics were used in 11% of patients with dementia, there’re were clear guidelines as to what the indications were in each case.The initiation of treatment was almost within the scope of specialist mental health services. The review was done by consultants. The indication for antipsychotics were psychotic symptoms (delusions and hallucinations) in nearly 40% of cases. In 50% of cases we tried to stop the antipsychotics with successful cessation in half of that sample.

Discussion:

It is clear that antipsychotics are infrequently used in older adult population with Dementia who are under the care of our teams (only 11%).

Conclusion:

The older adult psychiatry teams in Milton Keynes Primary care trusts are compliant with the Department of Health's guidance on the prescription of antipsychotics fro dementia patients (Nov 2009).

Non pharmacological methods of managing these behavioural and psychotic features were tried in 71%.
730 – Challenges between Adolescents' Independence and Restriction in Iranian Family
Authors: Shahhosseini Z. , Simbar M. , Ramezankhani A.
Published: July 2013

Background & Purpose:

Psychological-behavioral development of adolescents depends on regulations and rules of family. In this regard balance between adolescents' independence-restriction is one of the most important and challenging matters. This study conducted to evaluate adolescents and key informants' perceptions and experiences regarding to this challenge.

Material and methods:

This qualitative study was conducted in Sari in the North of Iran. Sixty-seven urban and rural female adolescents between 12-19 years of old participated in 8 focus group discussions. In addition, semi structured interviews were done with 11 key informants. Participants were selected based on purposeful sampling and with maximum variety. All taperecorded data was fully transcribed and thematic analysis was done to identify key themes.

Results:

Findings of this research lead to two main themes including: Family trust to adolescents (adolescents' independence, family supervision, not discrimination between children) and Respect to adolescents (kindness, attention).

Conclusion:

Providing a balance between independence and restriction in teens lead to promotion of self-esteem in adolescents which in turn reinforce her life skills abilities such as decision-making and critical thinking. So it is necessary to promote parents' knowledge and aware teens from family regulations which they must to meet.
734 – “You Say So, Who knows if it is True” Effects of Speaker's Social Hierarchy on the Sentence Comprehension
Authors: Santamaría García H. , Ayneto A. , Sebastián Gallés N.
Published: July 2013

Social hierarchies modulate cognitive processes. Nevertheless, the study of the influence of social hierarchy on sentence comprehension is scarce. We presented sentences with different levels of plausibility uttered by speakers with different hierarchical status (as previously established through a hierarchical video game) and measured the modulations of the N400 component. Participants heard three subsets of sentences with different plausibility value, depending on the last word (high, intermediate and low-plausibility). Sentences could be spoken by a superior or by an inferior status player. When listening to the superior player, the modulation of the N400 component followed the expected pattern (inverse relationship between amplitudes and sentence plausibility). However, when participants heard the Inferior speaker the amplitude of the N400 in high plausible sentences matched that of intermediate plausibility (increased). This result indicated that participants’ did not trust low rank speakers, even if sentences were high-plausible. We have observed specific personality traits modulating these hierarchical influences. The present research sets the ground for future studies exploring the influence of social hierarchies in other cognitive domains, specifically in relevant mental disorders where the social cognition is a nuclear field of symptoms such as the anxiety and other obssesive compulsive spectrum disorders.
742 – Internet Addiction and Related Addictive Behaviors in a Sample of Medical School Students
Authors: Floros G.D. , Siomos K.E. , Antoniadis D. , Stogiannidou A. , Giouzepas I. , Garyfallos G.
Published: July 2013

Introduction:

Internet addiction is a multi-faceted construct which is currently under review for inclusion in the forthcoming fifth edition of the Diagnostic and Statistical Manual of the American Psychiatric Association. In Greece, a specialized outpatient counseling service has been setup by our Psychiatric department in order to provide counseling for any students with related problems.

Objectives:

This survey has been setup in order to facilitate comparisons with those seeking help and validate the research measures used for their assessment. Furthermore, it sheds some light into Internet use from the future health professionals, an area of research that has been neglected.

Aims:

To gather data on student Internet use, social media use, online gaming and gambling, use of online sexual content and any addictive phenomena related to those behaviors.

Methods:

We employed an extensive battery of questionnaires identical to that employed by our counseling service. The battery includes detailed measures of all online behaviors, the SCL-90 psychopathology index, the Defense Styles Questionnaire (DSQ) and the Zuckerman-Kuhlman Personality Questionnaire (ZKPQ).

Results:

The presentation includes detailed results from the battery of questionnaires including comparisons with the validation samples and previous related research work carried out. Our sample demonstrated an unexpectedly high incidence of psychiatric symptoms and several cases of online addictive behaviors.

Conclusions:

Our results are demonstrating the need for a broader reach out to the target populations since a large number of students may be hesitant to seek help for their online addictions or simply prefer to ignore them.
746 – Insight as a Mediator between Stigma and Depression in Schizophrenia
Authors: Krupchanka D. , Katliar M.
Published: July 2013

Introduction:

The “Paradox of insight” in schizophrenia is a fact of its controversial impact with both positive and negative sides. It is known that insight and depression are positively correlated: the more awareness of schizophrenic illness, the more likelihood of depression. The mechanisms of this correlation have been clarified insufficiently at the moment.

Objective:

We hypothesized that the correlation between level of depression in patients and stigmatizing views of their close relatives depends on patient's illness awareness.

Materials and methods:

120 patients (response rate - 80%) with a diagnosis of “paranoid schizophrenia” were included in the cross-sectional, observational study. Following questionnaires were used: “The Scale to Assess Unawareness of Mental Disorder” (SUMD), “Calgary Depression Scale for Schizophrenia” (CDSS). The stigmatizing views were assessed in patient's closest relatives with questioner “Mental health in public conscience” developed by Iastrebov et all.

Results:

We have found statistically significant differences of correlations between patients’ groups with different level of insight (full, partial and absence of awareness of mental illness). Moreover, only in group of patients with full awareness of mental disorder the statistically significant correlation between level of depression in patients and intensity of stigmatizing beliefs in their close relative was found.

Conclusions:

Received data support hypothesis that the correlation between the level of depression in patients and the intensity of stigmatizing views of their close relatives depends on the patient's illness awareness.
747 – Brain-Derived Neurotrophic Factor and B-Cell Lymphoma Leukemia-2 Plasma Levels in Patients with Subsyndromal Symptomatic Depression
Authors: Li Z. , Fang Y.
Published: July 2013

Objective:

To explore the relationship between brain-derived neurotrophic factor (BDNF) and B-cell lymphoma Leukemia-2 (Bcl-2) plasma levels in subsyndromal symptomatic depression (SSD) patients.

Methods:

In this case-control study, Enzyme-Linked Immunosorbnent Assay (ELISA) method was used to analysed the differences of BDNF plasma levels between SSD group (n=42) and healthy controls (n=51). At the same time Hamilton Depression Rating Scale-17(HAMD17) were assessed the patients'severity.

Result:

There were significant difference of BDNF plasma levels between SSD group (medium 2.97 ng/ml)and healthy group (medium 3.71ng/ml, z=-2.94, P 0.003). Furthermore, BDNF plasma levels in SSD patients were associated with Hamilton score (r -0.53, P < 0.001). Plasma Bcl-2 levels were not different between SSD group (medium 4951 U/ml) and health controls (medium 5574 U/ml) (z = -1.71, P =0.09); and plasma Bcl-2 levels in SSD group were not associated with Hamilton score (r -0.10, P 0.34).

Conclusion:

The study suggested that the decreased BDNF plasma levels were related with the pathophysiology of SSD and it might reflect the severity of disorder.
749 – The Factors Associated with Occurrence of Suicidal Risk after Treatment of SSRI in Bipolar Disorder with their First Depressive Episode
Authors: Li Z. , Guan Y. , Fang Y.
Published: July 2013

Objective:

To explore the factors associated with occurrence of suicidal risk after treatment of Selective Serotonin Reuptake Inhibitor (SSRI) in bipolar disorder with their first depressive episode.

Methods:

One hundred and seventy seven bipolar patients were enrolled in this retrospective study. Demographic and clinic features between non-occurrence of suicidal risk group and occurrence of suicidal risk group were compared. Stepwise Logistic regression model was used to identify the associated factors. Concordance statistics (i.e. the area under the ROC curve) was used to compute the discrimination of the associated factors, and Hosmer-Lemeshow goodness-of-fit statistic was used to measure the goodness-of-fit.

Results:

One hundred and fifty four patients were included in non-occurrence of suicidal risk group, while twenty three were included in occurrence of suicidal risk group. Clinical features associated with occurrence of suicidal risk after treatment of SSRI in bipolar disorder were as follows: symptom of irritability (OR=4.04, 95 CI:1.40-11.67) and psychotic symptom (OR=6.23, 95 CI:1.40-27.56).

Conclusion:

This study demonstrated indicated that psychotic symptom and symptom of irritability were associated with occurrence of suicidal risk after treatment of SSRI in bipolar disorder, and it suggested that these two symptoms might be potential to be the predictors of occurrence of suicidal risk after treatment of SSRI in bipolar disorder.
766 – the Occurrence of Neurological Symptoms in Currently Abstinent Misusers of Alcohol
Authors: Khalily M.T. , Hallahan B.
Published: July 2013

Background:

Significant neurological symptoms may be overlooked because of the traditional view that the non-Korsakoff's psychosis, middle aged alcoholic misuser is neurologically preserved.

Aims:

In this study, we wanted to investigate the presence of neurological symptoms in individuals with misuse or dependence on alcohol who were abstinent for at least 1 month.

Method:

We used two scales from the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) to ascertain the presence of both neurological symptoms (HEA-2) and symptoms of general health concern (HEA-3) in 70 individuals who had a diagnosis of alcohol misuse or dependence, who were abstinent for greater than 1 month.

Results:

Individuals reported significantly more neurological symptoms than general health difficulties (p0.001). We detected neurological symptoms, unlike general health difficulties in individuals who were abstinent from alcohol for 12 months. When we examined diagnostic subgroups, general health difficulties were most present in individuals with anxiety disorders; however, neurological difficulties were present across diagnostic groups.

Conclusion:

Neurological symptoms persist to a greater extent than general health concerns in individuals who previously were dependent or misused alcohol.
771 – Communicability and Regret as Tools to Modify Occurrence and Future Outcome in Cases of Deliberate Self Harm
Authors: Sinha V. , Sharma I. , Paswan R.K. , Khan H.
Published: July 2013

Aims and objectives:

To assess the presence of communicability and regret in cases of deliberate self harm in a tertiary care hospital. to establish relation of communicability as a preventive sign and regret as a good prognostic sign in cases of deliberate self harm.

Methodology:

All consecutive patients with deliberate self harm presented to the emergency department during a 1 year period were assessed on a preformed Performa designed by authors after being declared physically fit and were screened by Standardized Assessment of Personality Abbreviated Scale (SAPAS), PSLES, HAM-D and HAM-A.

Result:

Majority of respondents screened negative by SAPAS scoring. Most of the patient had significant stress in life .Most of them had marital conflicts, family conflicts and economic burden as major stressor leading to suicidal behavior. Verbal communication was the most common mode of communication. Most of the subjects 86.3% (69 out of 80) had severe regret about their attempt of deliberate self harm. It developed a high motivation in them not to attempt suicide next time in life.

Conclusion:

Most of the suicidal acts are impulsive in nature and are not associated with any psychiatric co morbidity. Our study showed that if communicability is enhanced and this is considered seriously, providing supportive care by family most of the suicidal acts can be avoided. Regret arising after the suicidal act can be used to motivate the subject of deliberate self harm to avoid repetition of future attempts.
772 – Prevalence and Predictors of Depression in Patients with Systemic Lupus Erythematosus: a Cross-sectional Study
Authors: Maneeton B. , Maneeton N. , Louthrenoo W.
Published: July 2013

Objective:

The purpose of this study was to estimate the prevalence and examine the predictors of depression in patients with systemic lupus erythematosus (SLE).

Methods:

This cross-sectional study was conducted in a rheumatology clinic of university hospital. All SLE patients met the revised American College of Rheumatology (ACR) classification were included in the study. Socio-demographic data and medications were recorded. Disease activity for SLE was assessed with the Mexican-SLE Disease Activity Index (Mex- SLEDAI). All subjects were screened for anxiety and depression by using the Hamilton Anxiety Rating Scale (HAM-A) and the Hamilton Depression Rating Scale (HAM-D), respectively. Multivariate linear regression analysis was used to determine predictors of depressive disorder.

Results:

A total of 62 SLE (61 for females and 1 for male) patients participated in the study. Based on the HAM-D and HAMA, rates of depression and anxiety in the SLE patients were 45.2 and 37.1%, respectively. the multiple linear regression analysis revealed that HAM-A score and younger age were significant predictors of depression in the SLE patients.

Conclusion:

The finding suggests that depression and anxiety are common in the SLE patients. in addition, high level of anxiety and younger age may increase the risks of depression. Because of the small sample size, further studies should be conducted to warrant these results.
778 – Association of Apathy with Frontal Lobe Dysfunction in Amnestic Mild Cognitiveimpairment and Alzheimer's Disease
Authors: George M. , Whitfield T. , Walker Z.
Published: July 2013

Objectives:

The primary aim of this study is to examine an association between apathy and frontal lobe dysfunction in patients with memory problems. We also aimed to look into the association between apathy severity and caregiver burden along with the relationship between apathy and praxis.

Methods:

This was a retrospective cross sectional study. We selected 160 consecutive patients diagnosed with Alzheimer's dementia and Amnestic Mild Cognitive Impairment who had a comprehensive battery of neuropsychological tests and a behaviour rating scale of interest for this study recorded in the database. Correlation between apathy with and without depression were tested against frontal lobe test including Trail making A, Trial making B, Letter Fluency, Ideational Fluency, Category Fluency, Abstract Thinking and Executive functioning subtest of CAMGOG-R. Similarly correlation analysis was also done to look into association between apathy and caregiver burden as well as praxis.

Results:

Statistically significant relationship were found between apathy and executive function scores, ideational fluency scores, abstract thinking and category fluency scores. Relationship between apathy and caregiver burden were highly significant. Further sub analysis, found apathy to be significantly associated with caregiver burden in both AD and aMCI patients.

Conclusions:

Apathy is associated with frontal lobe dysfunction especially impaired executive function and ideational fluency even when controlled for depression. It is highly associated with caregiver burden both in AD & aMCI .Hence early recognition and management of apathy is important in improving the prognosis of patients with AD & aMCI as well as their caregiver.
783 – Memantine - A Possible Startup Key of Antipsychotics in Resistant Schizophrenia
Authors: Marinescu G.-C. , Rob L.A. , Popa S.N.
Published: July 2013

Introduction:

Although there are many antipsychotics, resistant schizophrenia is still to be an extremely important problem in psychiatrists' practice.

Objectives:

Finding a new strategy, different from the ones in daily standardized practice, could give better perspectives for the outcome of the cases of resistant schizophrenia.

Aims:

Adding memantine for about six months to the last antipsychotic used in the treatment of resistant schizophrenia could be used as a method in order to induce a response to the treatment due to modulation of NMDA receptors.

Method:

Two study cases: patients diagnosed with schizophrenia paranoid type, many years ago, with many hospitalisations for psychotic episodes admitted into the hospital for a psychotic relapse. the patients were treated with 2 antipsychotics (each for 8 weeks and adequate dose) without response. Both cases had a common approach from the moment of failure of the second antipsychotic: adding memantine 20 mg per day to the second antipsychotic, maintained with the same dose from that moment.

Results:

Adding memantine to the last antipsychotic induced the remission in both cases of resistant schizophrenia. This association was made for a period of 6 months and after that the dose of memantine was progressively reduced in 2 weeks. We kept the antipsychotic as a main treatment. the remission was kept during the period of association and one year after the withdrawal of the memantine.

Conclusions:

We think that memantine modulation of NMDA receptors in combination with antipsychotic D2 receptor blockade can improve the response of resistant schizophrenia.
784 – Clinical Outcomes of Depot and Well Being Clinic- Results of Physical Health Checks
Authors: Wildin H.
Published: July 2013

Background:

Physical health of people suffering from severe mental illness is a neglected area. They suffer more than general population and they die earlier. Looking after such disadvantaged group of people is mandatory, to improve their outcome and quality of life. Monitoring current clinical practice is essential to try to improve it.

Methods:

37 Records of patients who were on long acting injectable antipsychotics, attending the Taylor centre were selected and reviewed to establish their physical care arrangement check against the POMT-UK. Type of antipsychotics, whether they suffer from metabolic syndrome or not, other physical illness was recorded.

Results:

Records lacked any reference to baseline arrangements of physical monitoring. Although they demonstrated high level of physical morbidity, care and records didn’t reflect adequate clinical care to this important problem.

Discussion:

This study demonstrated that Physical care of people with severe mental illness is still substandard and needs to be developed in order to prevent or identify physical problems earlier, to reduce morbidity of these patients and improve their life expectancy and quality of life.

Conclusion:

Physical care is an important aspect of care of people who suffer from severe mental illness total care. This study has demonstrated that this area is still neglected. Improvement in this area will improve the global outcome of these disadvantaged people.
790 – Dual Diagnosis of Mental Illness and Substance Abuse: An Egyptian Study
Authors: Rady A. , Salama H. , Elkholy O. , Shawky A.
Published: July 2013

Background:

The dual diagnosis of substance abuse and severe mental illness has been proposed by some authors to highlight the high frequency of such association. Our objectif was to determine the prevalence of dual diagnosis among mentally ill patients. as a secondary purpose, to describe the profile of patient at higher risk to develop dual diagnosis.

Method:

683 mentally ill patients were recruited from el Mamoura Psychiatric Hospital, they were assessed by the Arabic version of 6 item K6 scale, those scoring above 13 were submitted to a structured clininical interview SCID-I (Modules A-E), urine screening for drugs of abuse and complete history of substance abuse and other medical disciplines.

Results:

22% of the sample fulfill the diagnosis of dual diagnosis. Results reveals higher risk for dual diagnosis in patients younger in age, single, low socioeconomic state and low level of education. Those having dual diagnosis tend to have early onset, longer duration of illness, poor compliance, higher rate of smoking and increased number of relapses.

Conclusion:

Double diagnosis is an important issue that needs more focus in mental health services. Awareness of mental health providers about dual diagnosis is highly recommended.
793 – Dual Diagnosis of Personality Disorder and Substance Abuse: The Need for Awareness
Authors: Rady A. , Salama H. , Elkholy O. , Shawky A.
Published: July 2013

Background:

The dual diagnosis of substance abuse and severe mental illness has been proposed by some authors to highlight the high frequency of such association. Our objectif was to determine the prevalence of dual diagnosis among mentally ill patients and and particularly personality disorder patients. as a secondary purpose, to describe the profile of patient at higher risk to develop dual diagnosis.

Method:

683 mentally ill patients were recruited from el Mamoura Psychiatric Hospital, they were assessed by the Arabic version of 6 item K6 scale, those scoring above 13 were submitted to a structured clininical interview SCID-II for personality disorder, urine screening for drugs of abuse and complete history of substance abuse and other medical disciplines.

Results:

22% of the sample fulfill the diagnosis of dual diagnosis. 12% of the sample had personality disorder, 57.32% among the later were fulfilling diagnosis of dual diagnosis. Results reveals higher risk for dual diagnosis in patients younger in age, single, low socioeconomic state and low level of education. No difference between different personality disorder subtypes as regarding rate of dual diagnosis.

Conclusion:

Double diagnosis is an important issue that needs more focus in mental health services. Awareness of mental health providers about dual diagnosis is highly recommended.
794 – Treating Personality
Authors: Ishizuka Y.
Published: July 2013

All psychiatric distress can be understood as the consequence of interaction between one's existing personality - the way one thinks, feels, and act - and life challenges.

Traditional treatment approaches have focused on understanding and treating various form of distress (symptoms), or consequences of above mentioned interaction.

Lifetrack therapy focuses squarely on personality, offering a quantifiable model of personality that can be tracked daily by the patients themselves on 41 parameters.

Working with the patient and his/her partner, Lifetrack therapy focus on increasing their closeness beyond their previous maximum experience, provoking and overcoming waves of defense (symptoms) until it weakens and disappears by exhaustion.

Results of 1,213 patients with all diagnosis treated with Lifetrack therapy showed that 50% reached a level of adjustment beyond their previous maximum level according to their own daily self-rating. Result was 4 times better when the patients were treated with their partners. of 224 patients with borderline personality disorder, the most challenging category of patient population, 70% reached or exceeded their previous maximum levels, with couples doing 10 times better than those without partners. 50% of BPD patients went through complete or near complete personality transformation.

Lifetrack therapy experience suggests that psychiatric symptoms of distress can be effectively treated through changing the patients' existing personalities, raising threshold of tolerance of challenges in life.
796 – Suicide Attempts in Chronic Pain Patients. A Register Study
Authors: Stenager E.N. , Christiansen E. , Handberg G. , Jensen B.
Published: July 2013

Introduction and aims:

The Centre for Suicide Research, Odense, Denmark has since 1990 registered all suicide attempts and suicides in patients residing in the County of Funen, Denmark.

The Pain Clinic, Odense University Hospital's receives patients with chronic pain from the whole region of Southern Denmark. This study is part of two studies from the Pain Clinic.

The aims of the study have been

To investigate whether patients treated in the Pain Clinic in the period 1/1 2004-31/12 2010 have an increased risk of suicide attempts compared with the background population

To investigate whether the frequency of suicide attempts before the treatment in the Pain Clinic differs from the frequency of suicide attempts after treatment.

Methods:

Data about age, sex and time of treatment on patients treated in the Pain Clinic in the period are registered. Time and method of the suicide attempts are registered in Centre of Suicide Research. By registry linkages between patient registers from the Pain Clinic and the Registry of Suicide Attempt in the County of Funen it was possible to calculate any excess risk of suicide attempts in chronic pain patients in the study period.

Results:

The Incidence rate ratio for suicide attempts in our study for both sex and all age group are about 1 or lower, which means that the pain population in our study does not have an increased risk of suicide attempts.
797 – Social Implication of Group Psychoterapy on Dual Diagnosis
Authors: Mitric B.
Published: July 2013

Introduction:

Center for Mental Health in Kotor was opened in 2005. year. in the center we apply modern methods in the treatment of substance addiction.

Objectives:

Objectives of this project are to understand the current way of functioning and the possibility of making new decisions.

Aims:

Raise awareness on the harmful effects of heroin, for their own health care and social functioning.

Methods:

Formed by a group which has eleven members. Two females, nine males. Age from 25 to 33 years. the paper applied the new method of treatment decisions. Before and during treatment was carried out satisfaction surveys using Manchester Short Assessment of Quality of Life (MANSA).

Results:

Members of groups that are unrealistic estimate the degree of satisfaction with life have left the program or had the resistance of the group. Other members who have had a more realistic self-assessment, regularly participated in the program. Their results MANSA at the start of treatment, pointed to dissatisfaction with social functioning, economic status and interpersonal relationships. At the end of treatment, MANSA indicating satisfaction personal safety, satisfaction with people with whom they live, physical pleasure and mental health. Three members have found employment.

Conclusions:

Group psychotherapy of dual disorder has effect on the level of social functioning. Members of the group have gained the insight that the concern for physical and mental health and social functioning is personal choice. Because group work and group work principles, the members have become more realistic in creating new life decisions.
800 – Prevalence of Prediabetes and Diabetes in Patients Treated with Antipsychotics
Authors: Steylen P. , van der Heijden F. , Verhoeven W.
Published: July 2013

Introduction:

Treatment with antipsychotic drugs is associated with an increased risk for glucose dysregulation.Hyperglycemia that does not fulfil diagnostic criteria for diabetes mellitus (DM) is known as prediabetes (preDM). PreDM is a strong risk factor for the development of DM and cardiovascular events.

Objectives:

To assess the prevalence of preDM and DM in patients on antipsychotic treatment.

Aims:

To compare cardiometabolic parameters between patients with normoglycemia, preDM and DM. in addition, incidence and reversal rates for preDM and DM were calculated in a one year follow-up.

Methods:

In a naturalistic cohort of 383 patients the fasting glucose and hemoglobin A1c criteria were applied. in addition, cardiometabolic parameters were measured. After one year, a second assessment was performed in 169 patients out of the total sample.

Results:

In the total sample, preDM and DM were present in 39% and 6% of antipsychotic treated patients, respectively. as compared to patients with normoglycemia, cardiometabolic parameters were more prevalent in patients with preDM. Although the majority of patients were diagnosed by the fasting glucose criterion, hemoglobin A1c contributed significantly to the number of patients identified. in a one-year follow-up, it was shown that the course of glucose metabolism can be dynamic.

Conclusions:

Systematic evaluation of glucose parameters in antipsychotic treated patients is warranted, in order to recognize glucose abnormalities at an early stage. Especially since fasting laboratory assessments are not required, including hemoglobin A1c as a diagnostic test is of additional value in identifying psychiatric patients (at risk for) DM.
801 – Comprehension and Companionship in the Emergency Department as Predictors of Treatment Adherence: a Prospective Study
Authors: Nitzan U. , Hirsch E. , Luria I. , Aviram S. , Walter G. , Bloch Y.
Published: July 2013

Introduction:

Lack of adherence to recommended treatment poses major clinical and economic challenges for psychiatry, and requires further study.

Objectives and aims:

We aimed to prospectively investigate the association between the level of understanding of psychiatric emergency department (ED) discharge recommendations and presence of a companion with short term treatment adherence.

Methods:

Sixty subjects were evaluated twice: upon ED discharge and a month later. Instruments included a structured questionnaire based on the MacArthur Competence Assessment Tool for Treatment, MMSE, and corroboration of data with the computerized hospital medical file.

Results:

There was a significant association between patient understanding and adherence with medication instructions (p< .01) and adherence to psychiatric follow-up (p< .05). There was also an association between the presence of a companion and adherence to medication instructions (x2(1)=7.0, p< .01).

Conclusions:

Ensuring patients' understanding of treatment recommendations and encouraging the company of patients are achievable, practical strategies that may improve adherence and thereby promote better outcomes.
819 – The Interpersonal Theory of Suicide and Adolescent Suicidal Behavior
Authors: Barzilay S. , Snir A. , Feldman D. , Apter A.
Published: July 2013

Studies of suicidal behaviour have provided valuable information about the risk factors associated with these behaviors, yet there is not much information about predictors of transitions from suicidal thoughts to actual suicide behavior.The current study aims to elucidate the mechanisms in which suicidal ideation emerges over time and how suicidal ideation can lead to suicidal actions.We attempt to determine the effects of psychopathology, non-suicidal self-injury (NSSI) and risk behaviors on suicidal behavior. This is examined through our model of youth suicidal behavior based on the theoretical framework of Joiner's Interpersonal Theory of Suicide.

Methods:

The prospective study design included baseline two follow-up assessments within a year. Follow-up sample included a total of 708 adolescents from schools throughout Israel. the students completed self-report questionnairesregarding suicide ideation and attempts, psychopathology, life style, socio-demographic background, non-suicidal self-injury, life events and social support.

Results:

Results indicate that interpersonal distress and internalizing disorders at baseline predicted later levels of suicidal ideation. the effects of interpersonal factors on ideation were partly or fully mediated by internalizing symptoms. We also found that increases in suicidal ideation and in engagement in risk behaviors and NSSI over time were associated with the occurrence of a suicide attempt within the follow up period.

Conclusions:

The model identifies the different phases along the path to suicidal behavior, and risk factors associated with each phase. Hopefully this model will improve our understanding of the short-term course of suicidal behavior among adolescents, which may lead to potential improvements for intervention and prevention.
824 – Social Functioning in Schizophrenia Offspring
Authors: Ienciu M.L. , Bredicean C.A. , Romosan F. , Giurgi-Oncu C.I.
Published: July 2013

Aim:

Between the risk factors for developing a first episode psychosis, social functioning is considered to be one of the most important factors.

The aim of the study is to compare social functioning in schizophrenia offspring and controls, and to determine possible associations between social functioning and prodromal symptoms.

Methods:

The study examined social functioning (by using the Social Functioning Scale) in 25 Schizophrenia offspring seeking psychiatric help for different problems, and 25 healthy controls.

Clinical status was assessed with the Brief Psychiatric Rating Scale, HAM-D and HAM-A.

Results:

Schizophrenia offspring had significantly more social functioning deficits than controls. Social functioning was most strongly associated with depression and anxiety symptoms and less with minor psychotic symptoms.

Conclusions:

Social functioning deficits precede the onset of first episode psychosis, especially in persons at risk and, therefore, it could represent an early detection sign. Association with depression and anxiety symptoms should be an early intervention point.
827 – Suggestibility in Persons with Schizophrenia
Authors: Iosebadze T.T. , Dzagania N.D.
Published: July 2013

Aim:

Study of suggestibility in persons with schizophrenia to ascertain whether it is advisable to use hypno-suggestive methods in the system of psychotherapeutic help to them.

Method:

As a method of study we used Barber's Creative Imagination Scale. to subjects of the experimental group this method was applied from 2 to 5 times, during 6 months.

Main results:

In the experimental group the subjects have been distributed in the following way:

(0)

lack of suggestibility - 12.68%;

(1)

weak degree of suggestibility - 20.56%;

(2)

average degree of suggestibility - 13.8%;

(3)

high degree of suggestibility - 24.51%;

(4)

very high degree of suggestibility - 28.45%.

In the control group we have obtained the following percentage distribution of subjects:

(0)

lack of suggestibility - 6.76%;

(1)

weak degree of suggestibility - 17.18%;

(2)

average degree of suggestibility - 22.25%;

(3)

high degree of suggestibility - 27.89%;

(4)

very high degree of suggestibility - 25.92%.

We also have studied changeableness of suggestibility during 6 months in the experimental group: invariable indices of suggestibility were shown by 27.95% of subjects; 37.26% of subjects had slight changeableness; suggestibility was considerably changed in 26.09% of subjects; and radical change was obtained in 8.7% of subjects.

Conclusion:

The obtained results point to the advisability of applying hypno-suggestive methods in the system of psychotherapeutic help of individuals suffering from schizophrenia.
831 – Self-stigmatization and Treatment Outcome of Pharmacoresistant Patiens with Anxiety Disorders in Komplex Inpatients Treatment Program
Authors: Ociskova M. , Prasko J. , Cerna M. , Grambal A. , Jelenova D. , Kamaradova D. , Latalova K. , Sedlackova Z. , Sigmundova Z.
Published: July 2013

Although several studies have assessed the relationships between stigmatization and treatment outcome of psychotic patients, relative little is known about the role of self-stigmatization and treatment outcome in patients suffering with anxiety disorders. Our study is designed to search for the relation between self-stigmatization and treatment outcome of pharmacotherapy resistant patients suffering with panic disorder, generalized anxiety disorder, social phobia, OCD and PTSD treated in complex program (cognitive behavioral therapy and pharmacotherapy) for anxiety disorders.

Method:

Sixty patients with pharmacoresistant anxiety disorder recommended for in-patient complex therapeutic program (combination of cognitive-behavioral therapy and pharmacotherapy) were evaluated during structured interview focusing on self-stigmatization with clinical psychologist. There were divided into 3 groups according level of self-stigmatization. the patients were treated in intensive 6 weeks cognitive behavioral therapy program combined with treatment of antidepressants.

Results:

Preliminary results show, that patients with high level of self-stigmatization improved less in complex therapeutic program than patients with low level of self-stigmatization.

Supported by:

IGA MZ CR NT 11047-4/2010
833 – Depression and Personality Disorders - Treatment Findings
Authors: Sedlackova Z. , Prasko J. , Cerna M. , Grambal A. , Jelenova D. , Kamaradova D. , Latalova K. , Ociskova M.
Published: July 2013

Although several studies have assessed the relationships between the personality and depression, relative little is known about the role played comorbid personality disorder in the treatment of the depression. Our study is designed to compare the shortterm effectiveness of therapy in patient suffering with social phobia with and without personality disorder.

Method:

The aim of the study was to assess retrospectively the efficacy of the in-patients therapeutic program for in patients suffering with depressive disorder and comorbid personality disorder (40 patients) and depressive disorder without comorbid personality disorder (40 patients). the electronic and paper documentation of age matched patients with depressive disorder and personality disorder and patients with depressive disorder without personality disorder hospitalized between years 2008- 2010 in Department of psychiatry of University Hospital Olomouc were randomly choose and studied and assessed by blind assessor according prepared criteria measured the efficacy of the treatment. the other factors for the analysis are the age, gender, dose of medication, comorbidity, length of the treatment, CGI and number of hospitalizations during 2 years follow up.

Results:

Preliminary results show, that patients of both two groups significantly improved during the treatment period. the outcome of patients with personality disorders was worse in the assessment of clinical state at the end of the index episode treatment, longer time of hospitalization, higher dosage of medication and higher number of hospitalization in follow up.

Supported by:

IGA MZ CR NT 11047-4/2010
837 – Request for Sex-reconversion Surgery - Case Report
Authors: Duisin D. , Barisic J. , Batinic B.
Published: July 2013

General data:

41 years-old; biological male; divorced; father of five children; university degree.

Chief complaint:

Regret following male-to-female sex-reassignment surgery (SRS) and facial plastic surgery; requesting sexreconversion operation.

Psychiatric history:

Compulsive, high-risk sexual behaviour, triggered by traumatic life-events during puberty (death of father and departure of mother at the age of 14). Symptoms evolved throughout adolescence and adulthood with persistent identity diffusion, intense abandonment fears, feelings of chronic emptiness and guilt, mood swings, unstable and intense interpersonal relationships, impulsivity and self-destructive behaviour. Gender history and transition: No evidence of gender nonconformity, gender dysphoria, gender-role discomfort or cross-gender identification. Uncertainty regarding male's role and identity diffusion, persisting since puberty. An impulsive decison for SRS and facial plastic surgery at the age of 40 (performed abroad), without a recommendation letter, motivated by the urge to resolve identity confusion and diminish compulsive sexual behaviour. He subsequently acknowledged his male identity, which led to relief of symptoms and request for sex-reconversion surgery.

Conclusion:

Gender history and clinical presentation confirmed that the patient did not sufficiently meet criteria for Gender Identity Disorder, but rather for Borderline Personality Disorder. the authors are highly aware that this topic is significantly connected to issues of the human right to free choice; however we would wish to impose a medical obligation for a rigorous psychiatric assessment for origin of gender identity diffusion and discomfort. Psychotherapy and pharmacotherapy should be the first treatment choices before any radical surgery interventions are undertaken.
840 – Heart Rate Variability In Panic Disorder Patients Before And After The Therapy
Authors: Diveky T. , Prasko J. , Cerna M. , Kamaradova D. , Grambal A. , Latalova K. , Ociskova M.
Published: July 2013

We assessed HRV (heart rate variability) in 31 patients with panic disorder before and after 6-weeks treatment with antidepressants and CBT and 18 controls. Patients were regularly assessed weekly on the CGI, BAI and BDI. HRV was assessed during 3 positions. Thirty one pharmacoresistant panic disorder patients entered a 6-week open-label treatment study. A combination of CBT and pharmacotherapy proved to be the effective treatment. Patients significantly improved in all rating scales. There were highly statistical significant differences between panic patients and control group in all components of power spectral analysis in 2nd (VLF, LF and H in supine) and in two component of 3rd (LF and HF in standing) positions. There was also statistically significant difference between these two groups in LF/HF ratio in supine position (2nd). We have found statistically significant differences in HRV frequencies between before and after CBT program in VLF in standing position. We have also found statistically significant differences in HRV frequency ratios in the third position in case of decrease VLF + LF / HF ratio. We can also see decreasing activity in VLF and LF band in standing position in1st measurement and an increase in VLF and LF band in standing position in 2nd measurement.

Conclusions

These findings demonstrate a lower autonomic power in panic disorder patients and tendency to increase it during the treatment.

Supported by: Project IGA MZ ČR NS10301-3/2009