bluuebunny/crossref_metadata_2025 huggingface dataset:
Constructing Wifely Identity: Prescription and Practice in the Life of Lady Sarah Cowper
Authors: Kugler Anne
Published: February 2004

July 25, 1700. My Custom hath been of late, to be in Bed from Nine to Six, the other 15 Hours I am 12 at least, alone. When I arose this Morn: I mett with a snare laid for me by an Instrument of the Enemy of Souls. … Since it is not possible for me to redress these Domestick greivances, I wou'd notice them to no other purpose, but to find by what means to sustain and bear them well. What if I try this expedient? Never to speak any thing but what is necessary to be said for some Use or End. that so my Mind may be kept more Close to the One thing Needfull, from which these vexations too much Distract it.

So began Lady Sarah Cowper's sixteen-year enterprise in self-justification. Between 1670 and 1700 this English gentlewoman had already filled a dozen commonplace books with extracts from poems, sermons, scripture, and essays, consciously searching for an emotional and intellectual outlet. But in July of 1700 with the added impetus of family scandal alongside long-term marital friction and financial instability, Lady Sarah started keeping a diary in which she reacted to her position—initially middle-aged and unhappily married, then elderly and widowed—and to events in her world. When she finally stopped writing because of ill health in September 1716, her daily entries totaled roughly 2,300 pages in seven volumes. This remarkable diary offers a specific link between the ideologies that institutions and authorities were concerned to promulgate and the outlook of the individual.
“Thoughts that Flash like Lightning”: Thomas Holcroft, Radical Theater, and the Production of Meaning in 1790s London
Authors: Karr David
Published: February 2004

During the 1790s, political speech in London's public spaces and commercial sites of leisure came under intense governmental surveillance. Fearing revolutionary infection from across the channel in France, the Pitt ministry sent spies into popular organizations such as the London Corresponding Society and turned more attention to other sites as well, including coffeehouses, taverns, debating-club rooms, and the street. Recently, historians too have explored the ways in which radicals manipulated the ludic vocabularies of urban sociability to critique the regime, protest persecution, and argue for reform. In this article I address a site that figured prominently as a place for radical speech in the 1790s: the Theatre Royal at Covent Garden. Although it was a site whose content was strictly regulated by the state through the office of the Examiner of Plays, the royal theater was, like other eighteenth-century theaters, a place where performances multiplied: viewers watched the play, but in the well-lit and noisy pit, boxes, and galleries, they watched other viewers intently. All were engaged in a complex process of performance, reception, and counterperformance. Indeed, as scholars have shown, theater audiences in late Georgian London were highly skilled at appropriating a theatrical grammar by which to demand their perceived rights as English subjects. Such strategies revealed the potency of theatrical representation in a society where, as Gillian Russell notes, “performance, display and spectatorship were essential components of the social mechanism.”
Catholic Protectionism or Irish Nationalism? Religion and Politics in Liverpool, 1829–1845
Authors: Dye Ryan
Published: February 2004

In August 1865, Liverpool's Catholic Bishop (1856–72), Alexander Goss, needed to find a priest. The bishop knew that Father Hardman of Birchley had grown too old to minister to a mission that was rapidly expanding because of Irish migration into the region. As he considered a replacement for Hardman, Goss made two specifications. First, the bishop sought to replace Hardman with a younger priest who could handle a growing congregation. Second, Goss intended to find an English priest to satisfy the local English Catholic baronet, Sir Robert Gerard. In a letter to Gerard, Goss lamented that “I have had some difficulty in making arrangements to fill his place; for being myself a Lancashireman I can well understand your dislike to have one from a country [Ireland] where nationality seems to override every other feeling.” Despite the region's expanding Irish population, the bishop sought to satisfy Gerard by recruiting an English priest. To Goss's frustration, however, most of the available priests were Irish.

Goss's comments illuminate the nineteenth-century English Catholic's prevalent concern: that Irish nationalism would supersede Catholicism in the hearts and minds of England's Catholic population, which was predominantly composed of working-class Irish migrants. The bishop knew that most Irish Catholics equated their Catholicism with Irish nationalism, while English Catholics like Gerard considered themselves a refined Catholic minority in a vulgar Protestant land. Goss struggled to bridge the ideological differences between English and Irish Catholics in Liverpool. He sought to accommodate working-class Irish migrants while appeasing English Catholic gentry like Gerard who supplied important money and respectability to the Catholic Church.
Pride and Prejudice: West Indian Men in Mid-Twentieth-Century Britain
Authors: Collins Marcus
Published: February 2004

Of all the immigrants arriving in Britain in the middle of the twentieth century, none attracted as much attention from whites as West Indian men. This was initially explicable by their being the first nonwhites to settle in large numbers. Around ten thousand arrived during the Second World War (more than Britain's entire prewar black population) and, although some two-thirds of them were hurriedly repatriated after 1945, returning ex-servicemen formed the majority of passengers disembarking from the Empire Windrush on 21 June 1948: year zero for mass black immigration. For the following decade, most of the Commonwealth immigrants coming to Britain each year were West Indian, and, of these, men outnumbered women by a ratio of roughly two to one.

In the late 1950s and 1960s, as their womenfolk joined them and as South Asians formed an ever-increasing proportion of new arrivals, it became clear that the prominence of West Indian men was more than merely numerical. It was cultural, stemming from the fascination-cum-revulsion of whites who customarily regarded them as vicious, indolent, violent, licentious, and antifamilial. These qualities were thought to differentiate them from their South Asian counterparts, who overcame an unsavory reputation acquired in the fifties to be viewed as the new Jews, placid and hard-working family men whose strict endogamy nullified their sexual charge. Much the same could be said for West Indian women, who posed less of a threat to white sensibilities on account of being considered less intemperate and sexually predatory than men.
Devotion, Discontent, and the Henrician Reformation: The Evidence of the Robin Hood Stories
Authors: Field Sean
Published: February 2004

The relationship between popular religious attitudes and the English Reformation has long been the subject of a fierce historical debate. The older “Whig-Protestant” view, championed most notably by A. G. Dickens, draws on evidence for clerical corruption and the spread of Lollardy to show that large numbers of English people were dissatisfied with the state of Catholicism, eager for religious change, and on the whole receptive to Protestant ideas. According to this version of events, Henry VIII and the Reformation Parliament rode a wave of popular discontent in breaking from Rome and dissolving the monasteries. If there was a split between the king and the masses, it came only later when Henry's conservative religious beliefs caused him to attempt to retain much of the substance of Catholicism in the face of popular clamor for more thoroughgoing reform. On the other hand, the “revisionist” camp, which includes such well-known names as J. J. Scarisbrick, Christopher Haigh, and Eamon Duffy, prefers to cite evidence from wills, local parish records, liturgical books, and devotional texts to show that “the Church was a lively and relevant social institution, and the Reformation was not the product of a long-term decay of medieval religion.” In this view, Henry VIII and his advisors pushed through a personally advantageous but widely disliked and resisted Reformation.

An examination of the religious content of the tales men and women told about Robin Hood in the late fifteenth and early sixteenth centuries offers a fresh perspective on this long-running dispute.
Pleasing Spectacles and Elegant Dinners: Conviviality, Benevolence, and Charity Anniversaries in Eighteenth-Century London
Authors: Lloyd Sarah
Published: February 2004

As the number and interests of charitable institutions expanded throughout Britain during the eighteenth century, so special fund-raising events, anniversary celebrations, and meetings multiplied. During 1775, for example, the major metropolitan charities and a plethora of minor benevolent societies courted middle- and upper-class Londoners with invitations to concerts and exhibitions. Men could support various hospitals and other good causes by dining in taverns and City Livery Halls in company with civic and ecclesiastical dignitaries, even noble and royal dukes. Both men and women might attend charities' anniversary services, ornamented with special music and a sermon, choosing among dispensaries, hospitals, lying-in charities, religious societies, and various efforts to reform and reclaim the poor for public benefit. On Sundays, armed with tickets, special prayer books, and even keys to their rented pews, women and men might attend the chapel of a philanthropic institution. Alternatively, they could listen to a fund-raising sermon and watch charity-school children arrayed in the gallery of a parish church. Toward the end of the year, they might pay half a guinea each to hear Handel'sMessiahin the Foundling Hospital Chapel or go to Covent Garden and Drury Lane to watch tragedies and farces. Charitable activity thus extended beyond churches, alms, and sermons into the theater. It spilled onto the streets as gentlemen processed to dinner; it accompanied art and music. Conversely, waves of fashion drove visitors to one philanthropic institution or another to see deserving recipients, hear a particularly popular preacher, or to be observed themselves.
Class, Gender, and the Conscientious Objector to Vaccination, 1898–1907
Authors: Durbach Nadja
Published: February 2004

In 1898, after forty-five years of enforcing mandatory infant smallpox vaccination, the British parliament passed an act to allow parents to “opt out” of the compulsory system. The 1898 Vaccination Act introduced a conscience clause that entitled parents who objected to the practice of vaccination to claim certificates of conscientious objection by applying to a magistrate for an exemption. This provided working- and lower-middle-class anti-vaccinationists a measure of relief from the repeated fines they had suffered for noncompliance with the law, and from the threat of imprisonment. By the end of 1898, over 200,000 certificates of conscientious objection had been issued. Many of these were granted in anti-vaccination strongholds where exemptions outnumbered vaccinations, but conscientious objection to vaccination was by no means limited to these regions. Once an amended conscience clause was passed in 1907, which made conscientious objector status much easier to attain, the national exemption rate grew to 25 percent of all births.

The vaccination conscience clauses were controversial. As most of the applicants who applied for these exemption certificates came from the working classes, and many were women, these acts generated a national debate over the classed and gendered nature of the conscience and the meanings of conscientious objection. The years between 1898 and 1907 thus mark a significant moment in the making of the modern subject and citizen. For, as the debate over conscientious objection to vaccination reveals, who exactly was entitled to make a claim to possess a conscience, with its concomitant rights, was itself a contested issue.
How Bunyan Became English: Missionaries, Translation, and the Discipline of English Literature
Authors: Hofmeyr Isabel
Published: February 2004

On 31 October 1847, the John Williams, a ship of the London Missionary Society, left Gravesend for the Pacific Islands from whence it had come. Its cargo included five thousand Bibles and four thousand copies of The Pilgrim's Progress in Tahitian. Like other such mission ships, the John Williams had been funded by the pennies and shillings of Sunday school subscription and had become a huge media spectacle. It was but one of the many international propaganda exercises at which mission organizations so excelled.

This picture of The Pilgrim's Progress (1678 and 1684) at the center of an international web is an appropriate one. Written in the wake of the English Revolution, the book had rapidly been disseminated to Protestant Europe and North America. By the late 1700s, it had reached India and by the early 1800s, Africa. Yet, some one hundred years on, this avowedly international image of The Pilgrim's Progress had been turned inside out. From being a book of the world, it had become a book of England. Today, John Bunyan is remembered as a supremely English icon, and his most famous work is still studied as the progenitor of the English novel. Roger Sharrock, in his introduction to the Penguin edition of The Pilgrim's Progress, best exemplifies this pervasive trend of analysis. His introduction begins by acknowledging Bunyan's international presence, but this idea is then snapped off from the “real” Bunyan who is local, Puritan, and above all English.
Thwarted Victors: Civil and Criminal Prosecution against Parliament's Officials during the English Civil War and Commonwealth
Authors: Shedd John A.
Published: February 2004

Whereas both Houses of the Parliament of England have been necessitated to undertake a war in their just and lawful defense … all oaths, declarations, and proclamations against both or either of the Houses of Parliament … or their ordinances and proceedings, or any for adhering unto them, or for doing or executing any office, place or charge, by any authority derived from them; and all judgments, indictments, outlawries, attainders and inquisitions in any the said causes … be declared null, suppressed, and forbidden. (From the first of nineteenNewcastle Propositions, July 1646; expanded from the first of twenty-sevenPropositions of Uxbridge, November 1644; repeated in the second ofThe Four Bills, December 1647)

Indemnity Committee cases from the 1647–55 manuscripts indicate a widespread volume of suits pressed against parliament's Civil War and Commonwealth officeholders. Invariably, the officials petitioning the Indemnity Committee were under prosecution. Often they had been fined and even jailed. Also revealed in these papers is a public knowledgeable in the law and ready to wield its power in punishing an array of officials in London and the shires. Four broad conclusions are asserted here. First, the Indemnity Committee records reflect a massive legal assault on state officials from the beginning of the Civil War to the mid-1650s, a factor in the political, administrative, and social history of the period that has heretofore been ignored. Second, suits were lodged mainly as the result of actions stemming from fiscal innovations put into place by a parliament that pushed toward victory and then struggled to pay its war debts.
Catharine Macaulay's Civil War: Gender, History, and Republicanism in Georgian Britain
Authors: Hicks Philip
Published: February 2004

The eighteenth century marked a watershed in the relationship between women and historical writing in Britain. Previous to this period, D. R. Woolf has demonstrated, women had certainly purchased, read, and discussed works of history, contributing to “the ‘social circulation’ of historical knowledge.” A few, perhaps most notably Lucy Hutchinson, had composed Civil War memoirs. Some women had written genealogical, antiquarian, and biographical works, as well as local and family history, a “feminine past,” according to Woolf, that men often judged unworthy of real history. Only in the eighteenth century, however, did women and men significantly modify a neoclassical paradigm that conceived of history as a strictly male enterprise, the record of political and military deeds written by men and for men. In this century prescriptive literature increasingly urged history upon women as reading matter intellectually and morally superior to novels and romances. The great triumvirate of British historians, David Hume, Edward Gibbon, and William Robertson, wrote expressly for female readers. Their “philosophical” history, with its shift of emphasis from political to social and cultural subjects, appealed to women, as did their experiments with the narrative techniques of sentimental fiction. The century also witnessed the appearance of the first female historian in Britain to write in the grand manner, Catharine Macaulay (1731–91). Mrs. Macaulay's success in the traditional genre of history won her the respect of male peers as well as the applause of a wide readership.
The Younger Generation: The Labour Party and the 1959 Youth Commission
Authors: Ellis Catherine
Published: February 2004

In 1956, Martha Gellhorn spent an evening exploring the uncharted territory of London's espresso bars. Her impressions were recorded in an article on “the younger generation”: “Full of expectations and ignorance, I made the long sight-seeing trip through the Espresso-bar country of London, stared at the young natives, and came gladly home at last with many pictures in my mind but little understanding …. The youthful Espresso-ites remained hopelessly strangers, in their strange, small, chosen land; I can only report what I have seen.” Gellhorn's account was punctuated by references to the “strangeness” of her experience. The decor of the bars invoked “distant places” with “bull-fight posters, bamboo, tropical plants, an occasional shell or Mexican mask.” As she traveled through this “strange country,” the sight of a tortilla was “terrifying,” the customers' clothing was breathtakingly exotic, and their skin tones suggested amalgams such as “Chinese-Javanese-Siamese” or “Spanish-Arab-Cuban.” At times, Gellhorn heard French and Italian spoken freely among the espresso bars' young patrons.

The foreign topography of youth culture described by Gellhorn was not unusual among accounts of young people in the 1950s, yet until recently this period has been characterized principally as a time of social peace and political apathy, “an age of prosperity and achievement” shaped by “consensus” and a return to normality after the disruption and sacrifices of the Second World War. Following an extended period of austerity, the welfare state and the managed economy seemed to have ensured full employment and an unprecedented standard of living, while the election of successive Conservative governments in 1951, 1955, and 1959 has been explained as the political reflection of rising personal prosperity and security.
Good Sports and Right Sorts: Guns, Gender, and Imperialism in British India
Authors: Procida Mary A.
Published: February 2004

In the early 1920s, a young British woman visiting India met the man she would subsequently marry. As the woman's daughter later revealed, she and her companions “were just sitting down to dinner when he came in through the door and one of the bearers came forward to take his gun and clean it, but my father would have none of that. He always cleaned his own gun before he did anything else. This impressed my mother.” If the narrative halted here, the contemporary reader might construe the story as yet another example of traditional gender dynamics. The love-struck young woman admiringly observes the male imperialist's competent, professional handling of his firearm, symbol both of his mastery over the colonized Indian landscape and its people and of his masculine sexual prowess. In this instance, however, the young woman was no passively adoring female quivering before this symbolic display of male power and sexuality. She herself, as her daughter revealed, had been “brought up with guns” and was a “crack shot.” Her admiration for the man who would become her husband stemmed not from feelings of awe or feminine inadequacy but rather from her cool assessment that here was someone who was her equal—and could be her partner—in hunting, shooting, and handling of firearms. Indeed as their daughter recalled, the successful marriage between these two gun aficionados was based in part on the wife's participation in her husband's hunting duties as an officer in the Indian Forest Service.
Britishness, Clubbability, and the Colonial Public Sphere: The Genealogy of an Imperial Institution in Colonial India
Authors: Sinha Mrinalini
Published: February 2004

The ubiquity of the European social club in the European empires in the nineteenth and early twentieth centuries has been widely recognized in both popular and academic writings on European, and particularly British, imperialism. The “European” ascription of imperial social clubs derived from their predominantly whites-only membership policy in which all elite Europeans, whatever their nationalities, were potentially included. Although each individual club often catered to a very different and distinctive clientele among elite Europeans in the empire, the “clubland” as a whole served as a common ground where elite Europeans could meet as members, or as guests of members, of individual clubs. These clubs, it has been argued, represented an oasis of European culture in the colonies, functioning to reproduce the comfort and familiarity of “home” for Europeans living in an alien land. The popular narrative of the club, as is evident from the account by the official historian of the Bengal Club, one of the oldest social clubs in India, easily oscillated between an understanding of the club as a broadly European cultural institution and as a specifically British one. Either way, the cultural values that it represented were understood as transplanted to the colonies: “It is the practice of European peoples to reproduce as far as possible in their settlements and colonies in other continents the characteristic social features of their natural lives …. For more than a century no institution has been morepeculiarly Britishthan the social club.”
Subject to Empire: Married Women and the British Nationality and Status of Aliens Act
Authors: Baldwin M. Page
Published: February 2004

The 1914 British Nationality and Status of Aliens (BNSA) Act stated that “the wife of a British subject shall be deemed to be a British subject, and the wife of an alien shall be deemed to be an alien.” By this reenactment of an 1870 law, a British woman who married an alien became an alien herself, losing the rights and privileges accorded to British nationality. During the 1920s and 1930s, British feminists from around the Empire worked to change this regulation, but only in 1948 were women in the United Kingdom granted the right to their own nationality regardless of their marital status. The House of Commons largely supported the feminists' efforts to reform the laws so that women would not automatically lose their nationality on marriage. Members of Parliament introduced several bills to equalize the nationality laws that were read without division. The Government, however, consistently blocked the bills, citing the imperial nature of the nationality laws and Dominion disagreement with the change. This contest over nationality has been a neglected topic in the study of twentieth-century British history. Legal historians have, by and large, only described changes in the laws regarding married women's national status. While some historians of the women's movement in the British Isles have noted the equal nationality campaign, most have not realized how it can contribute to our understanding of interwar Britain and British feminism. Pat Thane, however, has seen in this topic an example of the way the Empire has influenced British culture.
“There'll Always Be an England”: Representations of Colonial Wars and Immigration, 1948–1968
Authors: Webster Wendy
Published: February 2004

“In Malaya,” theDaily Mailnoted in 1953, “three and a half years of danger have given the planters time to convert their previously pleasant homes into miniature fortresses, with sandbag parapets, wire entanglements, and searchlights.” The image of the home as fortress and a juxtaposition of the domestic with menace and terror were central to British media representations of colonial wars in Malaya and Kenya in the 1950s. The repertoire of imagery deployed in theDaily Mailfor the “miniature fortress” in Malaya was extended to Kenya, where the newspaper noted wire over domestic windows, guns beside wine glasses, the charming hostess in her black silk dress with “an automatic pistol hanging at her hip.” Such images of English domesticity threatened by an alien other were also central to immigration discourse in the 1950s and 1960s. In the context of the decline of British colonial rule after 1945, representations of the empire and its legacy—resistance to colonial rule in empire and “immigrants” in the metropolis—increasingly converged on a common theme: the violation of domestic sanctuaries.

Colonial wars of the late 1940s and 1950s have received little attention in literatures on national identity in early postwar Britain, but the articulation of racial difference through immigration discourse, and its significance in redefining the postimperial British national community has been widely recognized. As Chris Waters has suggested in his work on discourses of race and nation between 1947 and 1963, these years saw questions of race become central to questions of national belonging.
Development of Novel Pharmacotherapies for the Treatment of Alcohol Dependence: Focus on Antiepileptics
Authors: Johnson Bankole A. , Swift Robert M. , Ait‐Daoud Nassima , DiClemente Carlo C. , Javors Martin A. , Malcolm Robert J.
Published: February 2004

Abstract: This article represents the proceedings of a symposium, “Development of Novel Pharmacotherapies for the Treatment of Alcohol Dependence: Focus on Antiepileptics,” presented at the 2003 annual meeting of the Research Society on Alcoholism in Fort Lauderdale, FL. The organizers and cochairs were Bankole A. Johnson and Robert M. Swift. The presentations were (1) Development of topiramate in the treatment of alcoholism, by Bankole A. Johnson; (2) Craving as a predictor of treatment outcome in pharmacotherapy trials for the treatment of alcoholism, by Nassima Ait‐Daoud; (3) Use of biomarkers as a predictor of treatment response in treating alcoholism, by Martin A. Javors; (4) Psychotherapy to enhance compliance with pharmacotherapy in treatment trials for alcohol dependence, by Carlo C. DiClemente; (5) Synopsis of promising medications to treat alcoholism, by Robert M. Swift; and (6) New knowledge on the development of antiepileptic medications for the treatment of alcoholism, by Robert J. Malcolm, Jr.
High‐Throughput Proteomics for Alcohol Research
Authors: Neuhold Lisa A. , Guo Q. Max , Alper Joseph , Velazquez Jose M.
Published: February 2004

Abstract: This report summarizes the proceedings of a satellite symposium of the 2003 Research Society on Alcoholism meeting held on June 21, 2003, in Fort Lauderdale, FL. The goal of this symposium, sponsored by the NIAAA, was to identify new proteomic directions in alcohol research that will (1) enable studies that focus on characterizing protein function, biochemical pathways, and networks to understand alcohol‐related illnesses; (2) identify protein‐protein interactions, posttranslational modifications, and subcellular localizations; (3) identify molecular targets for medication development; (4) develop biomarkers for susceptibility, dependence, consumption, and relapse, as well as alcohol‐induced pathologies; and (5) develop high‐throughput drug screens to test the efficacy of therapeutics that control alcohol‐induced diseases. The purpose of the symposium was also to promote the application of high‐throughput proteomic approaches, including isolation of membrane‐bound proteins, in situ proteomics, large‐scale two‐dimensional separations, protein microarray platforms, mass spectrometry, matrix‐assisted laser desorption/ionization, matrix‐assisted laser desorption/ionization time‐of‐flight, liquid chromatography‐tandem mass spectrometry, and isotope‐coded affinity tags. In addition, the development of protein network maps by using new bioinformatics approaches for database mining was also discussed.
Collecting Longitudinal Data Through Childhood, Adolescence, and Young Adulthood: Methodological Challenges
Authors: Faden Vivian B. , Day Nancy L. , Windle Michael , Windle Rebecca , Grube Joel W. , Molina Brooke S.G. , Pelham William E. , Gnagy Elizabeth M. , Wilson Tracey K. , Jackson Kristina M. , Sher Kenneth J.
Published: February 2004

Abstract: This article presents the proceedings of a workshop at the 2003 Research Society on Alcoholism meeting in Fort Lauderdale, Florida. The organizers and chairs were Vivian Faden and Nancy Day. The presentations were (1) Lessons Learned From the Lives Across Time Longitudinal Study, by Michael Windle and Rebecca Windle; (2) Methodological Issues in Longitudinal Surveys With Children and Adolescents, by Joel Grube; (3) The Pittsburgh ADHD Longitudinal Study: Methodological and Conceptual Challenges, by Brooke Molina, William Pelham, Elizabeth Gnagy, and Tracey Wilson; and (4) Lessons learned in Conducting Longitudinal Research on Alcohol Involvement: If Only I Had Known Before Hand! by Kristina Jackson and Kenneth Sher.
Pharmacological Treatment of Alcohol Abuse/Dependence With Psychiatric Comorbidity
Authors: Le Fauve Charlene E. , Litten Raye Z. , Randall Carrie L. , Moak Darlene H. , Salloum Ihsan M. , Green Alan I.
Published: February 2004

Abstract: This article represents the proceedings of a symposium at the 2003 annual meeting RSA in Fort Lauderdale, FL. It was organized and cochaired by Charlene E. Le Fauve and Carrie L. Randall. The presentations were (1) Introduction, by Charlene E. Le Fauve and Raye Z. Litten; (2) Treatment of co‐occurring alcohol use and anxiety disorders, by Carrie L. Randall and Sarah W. Book; (3) Pharmacological treatment of alcohol dependent patients with comorbid depression, by Darlene H. Moak; (4) Efficacy of valproate in bipolar alcoholics: a double blind, placebo‐controlled study, by Ihsan M. Salloum, Jack R. Cornelius, Dennis C. Daley, Levent Kirisci, Johnathan Himmelhoch, and Michael E. Thase; (5) Alcoholism and schizophrenia: effects of antipsychotics, by Alan I. Green, Robert E. Drake, Suzannah V. Zimmet, Rael D. Strous, Melinda Salomon, and Mark Brenner; and (6) Conclusions, by Charlene E. Le Fauve; discussant, Raye Z. Litten. Alcohol‐dependent individuals have exceptionally high rates of co‐occurring psychiatric disorders. Although this population is more likely to seek alcoholism treatment than noncomorbid alcoholics, the prognosis for treatment is often poor, particularly among patients with more severe psychiatric illnesses. Development of effective interventions to treat this population is in the early stages of research. Although the interaction between the psychiatric condition and alcoholism is complex, progress has been made. The NIAAA has supported a number of state‐of‐the‐art pharmacological and behavioral trials in a variety of comorbid psychiatric disorders. Some of these trials have been completed and are presented here. The symposium presented some new research findings from clinical studies with the aim of facilitating the development of treatments that improve alcohol and psychiatric outcomes among individuals with alcohol‐use disorders and co‐occurring psychiatric disorders. The panel focused on social anxiety disorder, depression, bipolar disorder, and schizophrenia.
The Veterans Aging Cohort Study: Observational Studies of Alcohol Use, Abuse, and Outcomes Among Human Immunodeficiency Virus–Infected Veterans
Authors: Conigliaro Joseph , Madenwald Tamra , Bryant Kendall , Braithwaite Scott , Gordon Adam , Fultz Shawn L. , Maisto Stephen , Samet Jeffrey , Kraemer Kevin , Cook Robert , Day Nancy , Roach Diedra , Richey Susan , Justice Amy
Published: February 2004

Abstract: This article represents the proceedings of a symposium at the 2003 annual meeting of the Research Society on Alcoholism in Fort Lauderdale, FL. The organizers/chairs were Joseph Conigliaro and Amy Justice. The presentations were (1) Introduction, by Joseph Conigliaro and Tamra Madenwald; (2) Alcohol and HIV/AIDS: the importance of integrative and translational research, by Kendall Bryant; (3) Alcohol use and abuse among patients with HIV infection, by Joseph Conigliaro and Stephan Maisto; (4) Severity of comorbid alcohol use/abuse in HIV infection, by Amy Justice and Jeffrey Samet; (5) Estimating the impact of alcohol use on long‐term HIV outcomes, by Scott Braithwaite and Amy Justice; (6) Homelessness, drug & alcohol use among HIV+ veterans, by Adam Gordon and Robert Cook; and (7) Hepatitis C & alcohol in the VACS 3 study, by Shawn Fultz and Kevin Kraemer. The symposium concluded with a discussion led and facilitated by Diedra Roach.
Alcohol‐Induced Neurodegeneration: When, Where and Why?
Authors: Crews Fulton T. , Collins Michael A. , Dlugos Cynthia , Littleton John , Wilkins Lincoln , Neafsey Edward J. , Pentney Roberta , Snell Lawrence D. , Tabakoff Boris , Zou Jian , Noronha Antonio
Published: February 2004

Abstract: This manuscript reviews the proceedings of a symposium organized by Drs. Antonio Noronha and Fulton Crews presented at the 2003 Research Society on Alcoholism meeting. The purpose of the symposium was to examine recent findings on when alcohol induced brain damage occurs, e.g., during intoxication and/or during alcohol withdrawal. Further studies investigate specific brain regions (where) and the mechanisms (why) of alcoholic neurodegeneration. The presentations were (1) Characterization of Synaptic Loss in Cerebella of Mature and Senescent Rats after Lengthy Chronic Ethanol Consumption, (2) Ethanol Withdrawal Both Causes Neurotoxicity and Inhibits Neuronal Recovery Processes in Rat Organotypic Hippocampal Cultures, (3) Binge Drinking‐Induced Brain Damage: Genetic and Age Related Effects, (4) Binge Ethanol‐Induced Brain Damage: Involvement of Edema, Arachidonic Acid and Tissue Necrosis Factor α (TNFα), and (5) Cyclic AMP Cascade, Stem Cells and Ethanol. Taken together these studies suggest that alcoholic neurodegeneration occurs through multiple mechanisms and in multiple brain regions both during intoxication and withdrawal.
Approaches to Brief Intervention for Hazardous Drinking in Young People
Authors: Saunders John B. , Kypri Kypros , Walters Scott T. , Laforge Robert G. , Larimer Mary E.
Published: February 2004

Abstract: This article represents the proceedings of a symposium at the 2002 joint conference of the Research Society on Alcoholism and the International Society for Biomedical Research on Alcoholism in San Francisco. The chair was John B. Saunders. The focus of the symposium was on brief intervention approaches for hazardous drinking among young people. The presentations were (1) Evidence for the effectiveness of brief intervention as an approach to reducing hazardous alcohol use, by John B. Saunders; (2) College student hazardous drinking in New Zealand, the USA, UK, and Australia: implications for research, policy, and intervention, by Kypros Kypri; (3) Applications of motivational feedback on the college campus, by Scott T. Walters; (4) A population based individualized alcohol harm reduction feedback intervention: preliminary results from the college‐based alcohol risk reduction (CBARR) trial, by Robert G. Laforge; and (5) Brief interventions: conclusions and future directions, by Mary E. Larimer.
Serotonin‐3 Receptors in the Actions of Alcohol, Alcohol Reinforcement, and Alcoholism
Authors: McBride William J. , Lovinger David M. , Machu Tina , Thielen Richard J. , Rodd Zachary A. , Murphy James M. , Roache John D. , Johnson Bankole A.
Published: February 2004

Abstract: This article represents the proceedings of a symposium at the 2003 annual meeting of the Research Society on Alcoholism in Fort Lauderdale, FL. The organizers and chairs were William J. McBride and David M. Lovinger. The presentations were (1) Mechanisms of alcohol potentiation of 5‐HT3 receptor function, by David M. Lovinger and Tina Machu; (2) Chronic alcohol drinking alters 5‐HT3 receptors regulating the mesolimbic dopamine system, by Richard J. Thielen; (3) 5‐HT3 receptors in the VTA regulate alcohol drinking and the reinforcing effects of alcohol, by Zachary A. Rodd and James M. Murphy; and (4) Ondansetron as a treatment for “biological” alcoholism, by John D. Roache and Bankole A. Johnson.
Biological and Behavioral Markers of Alcohol Sensitivity
Authors: Fromme Kim , de Wit Harriet , Hutchison Kent E. , Ray Lara , Corbin William R. , Cook Travis A.R. , Wall Tamara L. , Goldman David
Published: February 2004

Abstract: This article summarizes a symposium that was organized by Dr. Kim Fromme and presented at the 2003 annual meeting of the Research Society on Alcoholism in Ft. Lauderdale, Florida. The four presentations illustrate the emerging technologies and methods that are now being used to investigate the genetic basis of differential sensitivity to alcohol and their behavioral manifestations. Combining human genotyping with laboratory measures of behavior and subjective reports, these presentations represent state‐of‐the‐art approaches to crossing the bridge from the Decade of the Brain to the Decade of Behavior. Dr. De Wit's paper describes her research on the neurobiological basis for individual differences in sensitivity to the stimulant and sedative effects of alcohol. Evidence suggests that activity of the dopaminergic and GABAergic neurotransmitters underlie these stimulant and sedative effects, respectively. Both Drs. Hutchison's and Corbin's papers describe their research on polymorphisms for the serotonin transporter (SLC6A4) as a determinant of the subjective effects of alcohol challenge. Dr. Hutchinson's and Ms. Ray's findings indicate that individuals with the short form of the SLC6A4 alleles (S) demonstrated a low level of response to alcohol, thus supporting previous research that the S allele may be associated with increased risk for alcohol dependence. In contrast, Dr. Corbin did not find a reliable association between the SLC6A4 genotype and subjective response to alcohol. Mr. Cook's and Dr. Wall's paper adds another dimension to this article by presenting research on both the aldehyde dehydrogenase (ALDH2) and alcohol dehydrogenase (ADH2) genetic variants and their association with the alcohol‐related flushing response that is prevalent in Asian populations. Dr. David Goldman provides concluding remarks.
Integrative Neurobiology of the Alcohol Withdrawal Syndrome—From Anxiety to Seizures
Authors: Faingold Carl L. , Knapp Darin J. , Chester Julia A. , Gonzalez Larry P.
Published: February 2004

Abstract: This article represents the proceedings of a symposium presented at the 2003 Research Society on Alcoholism meeting in Ft. Lauderdale, Florida, organized and chaired by Carl L. Faingold. The presentations were (1) Overview, by Carl L. Faingold; (2) Stress, Multiple Alcohol Withdrawals, and Anxiety, by Darin Knapp; (3) Relationship Between Genetic Differences in Alcohol Drinking and Alcohol Withdrawal, by Julia Chester; (4) Neuronal Mechanisms in the Network for Alcohol Withdrawal Seizures: Modulation by Excitatory Amino Acid Receptors, by Carl L. Faingold; and (5) Treatment of Acute Alcohol Withdrawal and Long‐Lasting Alterations in Hippocampal Neuronal Networks, by Larry P. Gonzalez. The presentations emphasized the importance of using intact behaving animals to advance the understanding of the human alcohol withdrawal syndrome. This involves applying and amplifying the neurophysiological and neurotransmitter findings observed in vitro to the network‐based neurobiological mechanisms that are involved in several important aspects of the specific behaviors observed clinically. The symposium provided evidence that the organizational aspects of neuronal networks in the intact nervous system add another nexus for the action of alcohol and drugs to treat alcohol withdrawal that may not be readily studied in isolated neural elements used in in vitro approaches.
Building Bridges: The Transdisciplinary Study of Craving From the Animal Laboratory to the Lamppost
Authors: Monti Peter M. , Tidey Jennifer , Czachowski Cristine L. , Grant Kathleen A. , Rohsenow Damaris J. , Sayette Michael , Maners Natalie , Pierre Peter
Published: February 2004

Abstract: This article represents the proceedings of a symposium at the 2003 Research Society on Alcoholism meeting in Ft. Lauderdale, Florida, organized and chaired by Peter M. Monti. The presentations and presenters were (1) Alcohol Seeking and Self‐Administration in Rats: The Role of Serotonin Activity, by Cristine L. Czachowski; (2) Assessing Binge Drinking in Monkeys, by Kathleen A. Grant; (3) Craving and the Perception of Time, by Michael Sayette; (4) Ecological and Laboratory Assessment of Alcohol Urges and Drinking: Effects of Naltrexone, by Peter M. Monti; and (5) Discussion, by Damaris J. Rohsenow.
Serotonin 5‐HT2 Receptors and Alcohol: Reward, Withdrawal and Discrimination
Authors: Buck Kari J. , Reilly Matthew T. , Rogers Laura M. , Szeliga Ken , Grant Kathleen , Brodie Mark S.
Published: February 2004

Abstract: This article represents the proceedings of a symposium at the 2003 Research Society on Alcoholism meeting in Fort Lauderdale, Florida. The organizer was Karl J. Buck, and the chairperson was Mark S. Brodie. The presentations were (1) The Multiple PDZ Domain Protein May Mediate Genetic Differences in Ethanol Withdrawal Severity Via Interaction With 5‐HT2 Receptors, by Matthew T. Reilly and Kari J. Buck; (2) The Ionic Mechanism of Serotonin Potentiation of Ethanol Excitation of Ventral Tegmental Area Neurons, by Mark S. Brodie; and (3) 5‐HT2C Receptor Agonists in the Discriminative Stimulus Effects of Ethanol, by Laura M. Rogers, Ken Szeliga, and Kathleen Grant.
Overlapping Peptide Control of Alcohol Self‐Administration and Feeding
Authors: Thiele Todd E. , Stewart Robert B. , Badia‐Elder Nancy E. , Geary Nori , Massi Maurizio , Leibowitz Sarah F. , Hoebel Bartley G. , Egli Mark
Published: February 2004

Abstract: This article represents the proceedings of a symposium at the 2003 annual meeting of the Research Society on Alcoholism in Fort Lauderdale, FL. The organizers and chairpersons were Mark Egli and Todd E. Thiele. The presentations were (1) Voluntary alcohol consumption is modulated by central melanocortin receptors, by Todd E. Thiele; (2) Central infusion of neuropeptide Y reduces alcohol drinking in alcohol‐preferring P rats, by Robert B. Stewart and Nancy E. Badia‐Elder; (3) The gut peptide cholecystokinin controls alcohol intake in Sardinian alcohol‐preferring rats, by Nori Geary and Maurizio Massi; and (4) Hypothalamic galanin: a possible role in excess alcohol drinking, by Sarah F. Leibowitz and Bartley G. Hoebel.
The Future of Proteomics in the Study of Alcoholism
Authors: Kasinathan Chinnaswamy , Vrana Kent , Beretta Laura , Thomas Paul , Gooch Randy , Worst Travis , Walker Stephen , Xu Aaron , Pierre Peter , Green Heather , Grant Kathleen , Manowitz Paul
Published: February 2004

Abstract: This article represents the proceedings of a workshop at the 2003 annual meeting of the Research Society on Alcoholism in Fort Lauderdale, FL. The workshop organizers/chairpersons were Chinnaswamy Kasinathan and Paul Manowitz. The presentations were (1) Introduction to the field of proteomics, by Kent Vrana; (2) Use of proteomics in the identification of urinary biomarkers for alcohol intake, by Chinnaswamy Kasinathan, Paul Thomas, and Paul Manowitz; (3) Proteomics screening illuminates ethanol‐mediated induction of HDL proteins in macaques, by Kent Vrana, Randy Gooch, Travis Worst, Stephen Walker, Aaron Xu, Peter Pierre, Heather Green, and Kathleen Grant; and (4) Proteomics applied to the study of the liver, by Laura Beretta.
Consequences of Multiple Withdrawals From Alcohol
Authors: Duka Theodora , Gentry John , Malcolm Robert , Ripley Tamzin L. , Borlikova Gilyanna , Stephens Dai N. , Veatch Lynn M. , Becker Howard C. , Crews Fulton T.
Published: February 2004

Abstract: This article represents the proceedings of a symposium at the 2003 annual meeting of the Research Society on Alcoholism in Fort Lauderdale, FL, organized by Theodora Duka and chaired by Dai Stephens. The purpose of the symposium was to examine the effects of multiple experiences of withdrawal from alcohol in animals made dependent on alcohol and in humans who are alcohol dependent. Parallels were drawn to the effects of repeated short‐lived high‐content alcohol exposures in animals and in humans who are social drinkers but indulge in binge drinking. The presentations were (1) Multiple detoxifications and risk of relapse in abstinent alcoholics, by John Gentry and Robert Malcolm; (2) Emotional and cognitive impairments after long‐term use of alcohol: relationship to multiple detoxifications and binge drinking, by Theodora Duka; (3) The effect of repeated withdrawal from ethanol on conditioning to appetitive stimuli, by Tamzin Ripley, Gilyanna Borlikova, and Dai Stephens; (4) Alcohol withdrawal kindling: electrographic measures in a murine model of behavioral seizure sensitization, by Lynn Veatch and Howard Becker; and (5) Binge drinking induced changes in CNS, by Fulton Crews.
Really Underage Drinkers: Alcohol Use Among Elementary Students
Authors: Donovan John E. , Leech Sharon L. , Zucker Robert A. , Loveland‐Cherry Carol J. , Jester Jennifer M. , Fitzgerald Hiram E. , Puttler Leon I. , Wong Maria M. , Looman Wendy S.
Published: February 2004

Abstract: Despite the current societal concern with underage drinking, little attention has been paid to alcohol use within the preadolescent population. This article presents the proceedings of a symposium held at the 2003 Research Society on Alcoholism meeting in Fort Lauderdale, Florida, that was organized and chaired by John E. Donovan. The intent of the symposium was to kick start research on alcohol use among elementary school children by reviewing what is known regarding drinking in childhood. Presentations included (1) The Epidemiology of Children's Alcohol Use, by John E. Donovan; (2) The Validity of Children's Self‐Reports of Alcohol Use, by Sharon L. Leech; (3) Predicting Onset of Drinking From Behavior at Three Years of Age: Influence of Early Child Expectancies and Parental Alcohol Involvement Upon Early First Use, by Robert A. Zucker; and (4) Parent, Peer, and Child Risk Factors for Alcohol Use in Two Cohorts of Elementary School Children, by Carol J. Loveland‐Cherry. Presentations indicated the need for better nationwide surveillance of children's experience with alcohol; suggested that children's reports of their use of alcohol tend to be reliable and valid; supported children's alcohol use schemas and parental drinking and alcoholism at child age three as independent predictors of early onset drinking; and showed that onset of drinking before fourth or fifth grade, peer pressure, and parental norms and monitoring predict elementary student alcohol use and misuse.