bluuebunny/crossref_metadata_2025 huggingface dataset:
The Islamic Political Identity in Indonesia: A Study on Rejecting The Establishment of the Christian Church of Indonesia Yasmin
Authors: Ridho Moh. Zainor Ridho , Zaini Ahmad Zaini
Published: February 2024

The polemic of the Christian Church of Indonesia (GKI) Yasmin establishment, located in Bogor, has raised various kinds of new problems structurally and culturally. One of the problems at the structural level is the administrative polemic over the permit for the place's establishment of worship from the government of Bogor. On a cultural level, it is the emergence of conflict and intolerance between fellow Muslims—Islam vs. Islam or Islam vs. Christianity—whether social, political, legal, religious, or faith conflicts. The theoretical frameworks used to analyze the research questions are religious roles consisting of ideology, identity, social ethics, political Islamic movement theory, and human rights. The approach used in this documentary is qualitative. This research combines two methods of collecting data: primary and secondary. In-depth interview and cover In-depth Interview. This research determines the role of religion and politics owned by Islamic mass organizations (HTI and FORKAMI) in rejecting the establishment of GKI Yasmin in Curug Mekar Village, Bogor Barat Bogor. According to the research findings, religion has three roles: religion as ideology, HTI and Forkami as pressure groups (soft and complex pressure groups), and social-ethical. In the political context, the political roles of HTI and Forkami are structural Islamic political movements and cultural Islamic political movements.
Trans-Religious Genealogy: Jombang Community Resilience in Maintaining Tolerance in the Modern Era
Authors: Dodi Limas
Published: February 2024

Intolerance is still a socio-religious problem that leads to ongoing conflict. Intolerance gives birth to individualist attitudes, fanaticism, and communal legitimacy. In pluralist and multiculturalist countries, tolerance has not found strong, solid roots, especially withstanding changing times. Tolerance is often temporary, easily ignited by stigma and internal motives. However, in Jombang Regency, as a miniature showcase for a portrait of tolerant religious attitudes, it can survive convincingly amid modernity. Adherents of Islam, Catholics, Protestants, and Hindus can be tolerant under any conditions. Therefore, this research seeks to explore the ideological conception of religious diversity in Jombang as a manifestation of the ideal depiction of tolerance. This article is based on qualitative research with a phenomenological approach. Durkheim's social system theory is used as an analytical tool. Primary data was obtained from three religious adherents from religious and community figures. The research results revealed three things: 1) The genealogy of the religious tolerance values of Jombang society between Islam, Christianity, and Hinduism converges on the values of tasamuh, blessings, and the cult of God. 2) the resilience of tolerance amid modernity is created by a robust social structure, namely the genealogy of religious values, forming traditions, and the externalization of religious behavior. 3) religious transvalues create a tolerant categorization of religion, namely the connectivity of religious genealogy, internalization of religious traditions, and externalization of religious attitudes.
Religious Insurgency and Quest for Sustainable Peace in Nigeria: The Islamic Model as a Panacea
Authors: Lawal Manzoor Apenna , Dauda Kazeem Oluwaseun
Published: February 2024

The religious insurgency championed by the Boko Ḥarām movement has threatened Nigeria's quest for sustainable peace for more than a decade despite the counter-insurgency measures of successive governments. This paper examined Nigeria's turbulent decade of religious insurgency, its position within the Islamic context, and Islamically-inclined practicable solution to the threat. It used analytical research method based on existing secondary literature and primary Islamic law sources. The paper reveals that a turbulent decade of Boko Ḥarām insurgency has wreaked havoc on the peace and tranquillity previously existing among Nigeria's diverse ethno-religious entities. The analysis of Quranic texts, aḥādīth and opinions of notable scholars also indicates that religious insurgency associated with Boko Ḥarām is inconsistent with Islamic doctrines. Tolerance among religionists, proper religious teachings and interpretation of divine scripture, genuine inter and intra-faith dialogues, Islamic leadership-cum-governance paradigms, among others, were the identified Islamic-modelled panacea to the insurgency. The paper concludes that if the identified Islamic model can be embraced and considered in the scheme of things by religious and political leaders, as well as their ardent followers, the current religious insurgency would be drastically curtailed, thereby advancing sustainable peace in Nigeria.
Intellectual Resurgence for Contemporary Muslim Societies Adopting Malek Bennabi Social Change Paradigm
Authors: Jamil Jamaliah
Published: February 2024

This article describes the life and beliefs of Malek Bennabi, a figure who contributed and had a significant impact on Muslim society. Through his writings and ideas, Bennabi has left a legacy that inspires and motivates him to create a better future for the Muslim world. In addition, this research aims to provide a systematic literature review based on selected journals that specifically highlight Malek Bennabi's work with contemporary scholars to strengthen his intellectual legacy. The results of the systematic literature are: Bennabi's ideas about the challenges faced by Muslims, such as political or social marginalization and economic recession, can still be applied to current conditions, such as increasing corruption, Artificial Intelligence, the Internet of Things, mainly social media disruption of the principles of Muslim life. Moreover, while technology and progress often seem to come at the expense of traditional values, Bennabi's emphasis on the importance of creativity and the Islamic faith is particularly compelling. Finally, the findings of this study contribute to understanding the methodology, intellectual achievements, and their possible applications in post-modern society.
Implementation of Good Corporate Governance Principles in Bank Syariah Indonesia Nganjuk Sub-Branch
Authors: Mawadah Nurmaika Nasyiati , Marsudi Kenlies Era Rosalina
Published: February 2024

Introduction: Insufficient implementation of Good Corporate Governance (GCG) is the cause of financial instability which has an impact on deteriorating bank financial performance and causes failure in GCG implementation. This research aims to find out what factors support and hinder the implementation of GCG in Bank Syariah Indonesia Ahmad Yani Nganjuk Sub-Branch. Research Methods: This research uses qualitative research with a descriptive qualitative approach. The data collection methodology consists of observation, interviews and documentation supported by secondary data sourced from the BSI Syariah website. Result: The results of this research show that the implementation of the five GCG principles can be described as follows: the company is transparent in providing various services, various provisions regarding corporate responsibility have been made and implemented. Fairness indicators have also been given great attention in various aspects. However, in the principles of accountability and professionalism, there are still obstacles, including employees not being punctual and not being disciplined regarding their respective job descriptions. Conclusion: The conclusion of this research is that Bank Syariah Indonesia Nganjuk sub-branch has implemented GCG principles even though there are still several factors that cause some indicators to not be optimal. It is necessary to carry out training, evaluation and work monitoring for employees.
Factors that Influence to Costumers Sharia Bank Loyalty: An Empirical Study of Students at Universitas Darussalam Gontor Ponorogo
Authors: Rofiqo Azidni , Wicaksana Febrian Arif , Abd Razak Abdurrizqi Bin
Published: February 2024

Introduction: The purpose of this research is to predict customer satisfaction, customer perceived value, and customer Islamic religiosity on Sharia bank customer loyalty. Research Methods: The research used a quantitative approach with 140 respondents who were Sharia bank customers, specifically students at Universitas Darussalam Gontor, Ponorogo. A Likert scale of 1-5 was employed for measurement, and partial least squares–structural equation modeling was used to analyze the data. Results: The results of this research demonstrate that customer satisfaction, perceived value, and Islamic religiosity have a significantly positive impact on Sharia bank customer loyalty. Conclusion: To build and maintain customer loyalty, Islamic banks must leverage customer satisfaction, value, and religiosity by offering a variety of Sharia-based products and services that truly differentiate them from conventional banks.
QUARTET LEARNING MEDIA AND STUDENT ARGUMENTATION: DEVELOPMENT ANALYSIS AND CORRELATION IN SCIENCE LEARNING IN JUNIOR HIGH SCHOOLS
Authors: Qolbyatin Nur Asa , Septaria Kiki , Wulandari Siska Ayu
Published: February 2024

Argumentation is essential in scientific learning activities because it helps students grasp concepts and apply their knowledge in real-life situations by presenting the same notion in multiple settings. The purpose of this study is to investigate students' scientific argumentation skills using a science quartet educational game. The Research and Development approach is used in this study, along with the ADDIE (Analysis, Design, Development, Implementation, and Evaluation) model phases. This study's sample consisted of class VIIIB students from SMPN 2 Sugio, with a small group trial of 15 students and a large group test of 32 students, for a total of 47 individuals. Techniques for gathering data include observation, testing, and surveys. This study included four specialists: media experts, practitioners, material experts, and linguists. The validity test, N-gain, t-test, and correlation were used to examine the data. The validity test findings demonstrated the practicality of the scientific quartet educational game with percentages of 86% and 100%, indicating extremely valid categories. The science educational game quartet had an influence on students' scientific arguments with a significant value of 0.05, as indicated by an increase in the cognitive N-gain test results and students' scientific arguments by 0.75 (high category) after evaluating the paired sample t-test. The correlation test findings revealed a link between the science quartet educational game and students' science arguments with a significance value of 0.05, placing it in the strong positive category. The findings of the study show that science quartet educational game are useful in the learning process.
FACTORS AFFECTING THE ABILITY OF SCIENCE PRE-SERVICE TEACHERS OF ELEMENTARY EDUCATION IN INDONESIA
Authors: Sumantri Mohamad Syarif , Wibowo Firmanul Catur
Published: February 2024

This study aims to obtain information on the effect of attitudes towards science, achievement motivation and learning activities on science learning outcomes. This research has been conducted in the elementary school teacher education institutions in Jakarta, Bogor and Tangerang District, Indonesia. In this study, 200 samples were randomly selected, and data was collected through a survey. The respondents were the students who took the science course. This study used quantitative approach, survey methods, and path analysis. Data were analyzed using descriptive analysis, analysis of the requirement test, and inferential analysis. The research findings indicate: 1) science learning outcomes are positively influenced directly by attitudes towards science, achievement motivation and learning activities, 2). learning activities are directly influenced positively by attitudes towards science and achievement motivation. on these findings, it can be concluded that the increase in science learning outcomes is influenced by attitudes towards science, achievement motivation and learning activities.
IMPLEMENTING SCIENTIFIC METHOD TO STRENGTHEN THE STUDENT'S SCIENTIFIC ATTITUDE: A STUDY ON BIOLOGY SUBJECT
Authors: Chheun Seyha , Kong Sam Ol
Published: February 2024

The scientific method was actually defined in many different ways up to the contextual of learning. This study is to implementing scientific method to strengthen the scientific attitude: A case study of Class 8 students in the subject of Biology. The main objective of this research is on how the implementation of Scientific Method affects scientific attitude of grade 8 students in Biology. The samples of this study involved with18 students for observation and 3 students for interviewing. The students were chosen from class8 for data collection. The data analyzing in this research was used Thematic Analysis method with the variation of observation. Based on the observation, the students were not familiar with the scientific method yet at the first time of class compared with the last observation, students processed activities at higher level. All of the criteria of scientific attitudes were contributed. Moreover, the result from interview is supported to the improvement of students’ scientific attitudes by implementing scientific method. Therefore, it can be concluded that, the implementation of scientific method imposed scientific attitudes in the classroom. The findings identified that scientific method strengthen students' scientific attitude toward learning such as: curiosity, honesty and objectivity, critical resonating, open minded and cooperation, and responsibility. The further research should apply scientific method for a longer period to make students to be familiar with the method. Moreover, the researcher should spend more time observing or interviewing teachers to get the result more accurately.
PERLINDUNGAN HAK SPIRITUAL KONSUMEN MUSLIM DALAM PROGRAM SERTIFIKASI HALAL JALUR PERNYATAAN PELAKU USAHA (SELF DECLARE)
Authors: Anggraini Rooza Meilia , Imtihanah Anis Hidayatul , Bashori Yudhi Achmad
Published: February 2024

The end of the Government Regulation in Lieu Law No. 2 of 2022 concerning Job Creation significantly changes the Halal Product Guarantee Law. The Indonesian Ulema Council is no longer authorized to issue fatwas on products filed under the Self Declare program. The transition from the Fatwa Commission to the Fatwa Committee, whose members are academics and ulama, as well as the accelerated halal certification program for institutions under the Ministry of Religion, may provide opportunities for violations for both business actors and PPH assistants, potentially affecting the spiritual rights of consumers. This article examines the government's strategy for promoting the halal business through self-declaration and comprehending the notion of ensuring Muslim customers' spiritual rights in the self-declare halal certification program. This normative legal research article has a conceptual, statutory, and case approach. This research is classified as library research since it relies on library materials as a normative legal research data source. According to the study's findings, the self-declare program is one of the government's methods for achieving 10 million halal certificates by 2024. However, this program needs further evaluation, particularly in terms of supervision. If PPH assistants and business actors apply the provisions of the Law, the spiritual rights of consumers as part of their religious rights granted by the Constitution can be fulfilled.
KONFLIK HUKUM LEGALITAS PERKAWINAN BEDA AGAMA DI INDONESIA
Authors: Alifa Hasna Lathifatul , Sodiqin Ali , Ambarayadi Bian
Published: February 2024

This article explores legal conflicts regarding the legality of interfaith marriages in Indonesia. There was a legal conflict between the provisions in Article 2 paragraph (1) of Law No. 1 of 1974 concerning Marriage, which determines the validity of marriages based on religious law, with Articles 34 and 35 of Law No. 23 of 2006 concerning Citizenship Administration, which states that a valid marriage is reported and registered. Article 35, letter (a) says that the court determines a legal marriage. Disharmony of laws and regulations concerning interfaith marriage regulations has influenced the interpretation of legal provisions, resulting in differences in judges' decisions. This raises the question of harmonizing the legal provisions between these laws and regulations. Analysis of the problem of the legality of interfaith marriage law is carried out using a normative juridical approach by using Soerjono Soekanto's theory of legal effectiveness. The results of this study indicate that the disharmony of interfaith marriage law causes multiple interpretations for judges in determining the legality of interfaith marriages. Unclear regulations cause the legal rules of interfaith marriages in Indonesia to cause conflicts between legal institutions. The legal substance factor is the main root of the ineffectiveness of the regulations on interfaith marriages in Indonesia. Disharmony between legal authorities impacts conflicts between legal institutions and influences the practice of interfaith marriages in society.
Dynamics of Child Marriage in Suku Anak Dalam Community
Authors: Hidayati Rahmi , Yanti Illy , Farhan HR Muhammad , Othman Shahrul Hilmi
Published: February 2024

This paper aims to explain the dynamics of child marriage and its impact on the Suku Anak Dalam community. This research uses observation, interview, and documentation methods, in which researchers directly go to the field to observe and interview perpetrators of early marriages and tribal chiefs. The results of the study show that the Suku Anak Dalam community has its own rules and traditions regarding the appropriate age limit for marriage and does not include provisions in the law that have been positive. This tradition is a way of measuring the maturity of the bride and groom. According to the Suku Anak Dalam, men can get married if they can earn a living through skill tests in hunting animals or are suitable for farming. At the same time, women are considered adults if they have menstruated. Child marriage is generally a tradition passed down from generation to generation and is an unwritten legal system in society. This practice is a form of neglect regarding women's rights in domestic life, which impacts divorce, physical health, malnutrition, and marriage administration. Several factors, including tradition, arranged marriages/endogamous marriages, economics, promiscuity, and gender inequality, cause this child marriage.
INDIVIDUAL BEHAVIOUR FORMED BY ISLAMIC EDUCATIONAL INSTITUTIONS IN INDONESIA: ANALYSIS-DESCRIPTIVE STUDY
Authors: Muzakki Hawwin , Natsir Ahmad , Nuha Muhammad Afthon Ulin
Published: February 2024

This research will examine how organizational institutions influence the formation of individual behaviour, while many other studies emphasize how individual behaviour influences organizational culture. This research will provide a broader picture of the factors that influence the formation of individual behaviour, especially from the perspective of organizational institutions. The method used in this research is a literature study, which collects data through written sources such as relevant journals and books. Data analysis was done using descriptive analysis, looking for patterns and finding themes from the collected materials. This study concludes (1) Islamic educational institutions in Indonesia can shape the biographical character of moderate Indonesian Islam, (2) Islamic educational institutions in Indonesia seek to shape individual behaviour that has the expected abilities following Islamic teachings and principles, (3) Islamic educational institutions in Indonesia strive to form positive personalities, namely individuals who have integrity, professionalism, innovation, responsibility and exemplary. (4) The process of behaviour change that occurs in Islamic educational institutions in Indonesia can occur through social interaction, understanding of Islamic teachings, and the relationship between individual behaviour and the consequences it produces. Penelitian ini akan mengkaji bagaimana institusi organisasi mempengaruhi pembentukan perilaku individu, sementara banyak penelitian lain yang menekankan bagaimana perilaku individu mempengaruhi budaya organisasi. Penelitian ini akan memberikan gambaran yang lebih luas mengenai faktor-faktor yang mempengaruhi pembentukan perilaku individu, terutama dari sudut pandang institusi organisasi. Metode yang digunakan dalam penelitian ini adalah studi literatur, yaitu pengumpulan data melalui sumber tertulis seperti jurnal dan buku yang relevan. Analisis data dilakukan dengan menggunakan analisis deskriptif, mencari pola dan menemukan tema dari bahan yang dikumpulkan. Penelitian ini menyimpulkan (1) Lembaga pendidikan Islam di Indonesia dapat membentuk karakter biografi Islam Indonesia yang moderat, (2) Lembaga pendidikan Islam di Indonesia berupaya membentuk perilaku individu yang memiliki kemampuan yang diharapkan sesuai dengan ajaran dan prinsip Islam, (3) Pendidikan Islam institusi di Indonesia berupaya untuk membentuk pribadi-pribadi positif, yaitu individu-individu yang mempunyai integritas, profesionalisme, inovasi, tanggung jawab dan keteladanan. (4) Proses perubahan perilaku yang terjadi pada lembaga pendidikan Islam di Indonesia dapat terjadi melalui interaksi sosial, pemahaman ajaran Islam, dan hubungan antara perilaku individu dengan akibat yang ditimbulkannya.
Distinction of Millennials and Generation Z Islamic Literacy: A Comparative Study of Reading Preferences at UIN Sayyid Ali Rahmatullah Tulungagung
Authors: Taufiqurrohim Taufiqurrohim
Published: February 2024

Abstract: The characteristics of the generation are related to the side of Islamic behavior that they should adhere to. We can analyze the selection of literacy commonly used in studying Islam. However, the challenge is increasing the prevalence of various literacy that does not introduce tolerance and diversity, even leading to radicalism. Therefore, mapping the relationship between generation categories and literacy selection is used, especially in the Higher Education environment, considering its role as a center for knowledge development. Through the mixed method, this study tries to compare the use of literacy between 2 different generations, namely Millennial and Z, at UIN Sayyid Ali Rahmatullah. The results of this study show that first, Millennials tend to use gadgets to obtain Islamic knowledge compared to Generation Z, who prefer to learn Islam face-to-face or in person. Second, Gen Z finds less radical content than millennials, who show how their interest in the issue of radicalism is lower as a form of their apathy on the issue. Third, Gen Z is more acknowledging that they know what kind of Islamic content to avoid than Gen Y, but this is just a matter of the general meaning of their version of radicalism rather than specific to characters, books, or other sources that should be avoided.Keywords: Gen Z , Islamic literacy, MillennialAbstrak: Karakteristik generasi berhubungan dengan sisi perilaku keislaman yang seharusnya mereka anut. Hal itu bisa kita analisis pemilihan literasi yang biasa dipakai dalam mempelajari Islam. Namun demikian, tantangan saat ini mengarah pada makin maraknya berbagai literasi yang tidak memperkenalkan toleransi dan keberagaman bahkan mengarah pada radikal. Oleh karena itu, pemetaan hubungan antara kategori generasi dengan pemilihan literasi yang dipakai terutama di lingkungan Perguruan Tinggi, perlu dilakukan mengingat perannya sebagai pusat berkembangan pengetahuan. Melalui metode mix method, penelitian ini mencoba untuk membandingkan penggunaan literasi yang digunakan antara 2 generasi yang berbeda yaitu Millenial dan Z, di UIN Sayyid Ali Rahmatullah sebagai salah satu PTKIN terbesar di Indonesia. Hasil dari penelitian ini menunjukkan yaitu pertama, milenial memang cenderung suka menggunakan gadget dalam memperoleh pengetahuan keislaman dibanding generasi Z yang lebih menyukai belajar islam via tatap muka atau langsung. Kedua, Gen Z lebih jarang menemukan konten yang berbau radikal dibanding milenial dimana menunjukkan bagaimana ketertarikan mereka terhadap isu radikalisme lebih rendah sebagai wujud apatisme mereka pada isu tersebut. Ketiga, Gen Z lebih mengakui bahwa mereka tahu konten keislaman seperti apa yang harus dihindari dibanding Gen Y, akan tetapi hal ini hanya sekedar secara umum arti radikal versi mereka bukan spesifik pada tokoh, buku ataupun sumber lainnya yang seharusnya dihindari.Kata Kunci: Gen Z, Literasi keislaman, Milenial,
Perkembangan Sosial Emosional Anak Usia Dini Usia 4-5 Tahun Melalui Permainan Klasik Bakiak Perspektif Epistemologi
Authors: Saputri Indri Dwi , Maemonah Maemonah
Published: February 2024

Pada anak usia dini, kegiatan sosial biasanya dikembangkan melalui bermain atau menggunakan media untuk menunjukan kegiatan sosial bersama teman-temannya. Kegiatan tersebut dapat dilakukan melalui permainan klasik. Banyak permainan klasik yang dapat merangsang aktivitas sosial anak. Banyak permainan klasik yang dapat merangsang aktivitas sosial anak. Tujuan pelaksanaan permainan ini adalah untuk melatih kemampuan sosial dan emosional anak. Metode yang dipilih adalah kualitatif. Informasi diperoleh melalui wawancara, observasi dan dokumentasi. Menganalisis data digunakan analisis deskriptif berdasarkan data lapangan yang hasilnya pada saat ini sebagian besar anak mengalami perkembangan sosial emosional dalam kriteria perkembangan sangat baik. Sehingga indikator keberhasilan telah tercapai. Kegiatan peningkatan perkembangan sosial emosional anak melalui permainan klasik bakiak kelompok A termasuk dalam kategori berkembang sangat baik artinya sudah banyak peningkatan yang sangat penting yaitu perkembangan yang sangat penting yaitu perkembangan sosial emosional anak.
Phenomenology Studies: College Student Experience in Early Childhood Learning Based on Neuroscience Studies
Authors: Faizah Ulinnuha Nur , Al Baqi Safuruddin , Fadly Wirawan
Published: February 2024

Neuroscience in learning is a study that studies the brain in terms of anatomy and physiology and its correlation with learning. This study analyzed the ability of research subjects to link learning in early childhood with neuroscience studies. This study uses a qualitative method with a phenomenological approach. The research subjects were PIAUD IAIN Ponorogo students taking Neuroscience courses in the 2022/2023 academic year. The learning methods for early childhood analyzed in this study included drum bands, drama, movements and songs, singing, modern and traditional dance, games, and stories or fairy tales presented in work performances. Data collection was carried out through documentation and interviews. The research data were analyzed using the Miles and Huberman Analysis model, which consisted of three steps: reduction, data presentation, and drawing conclusions. Results Analysis of the research data showed that the research subjects could link learning in early childhood with neuroscience studies and knew the importance of learning in early childhood based on neuroscience studies.
Co-expression network analysis illustrates the importance of driver genes in colorectal cancer diagnosis, prevention, and therapy
Authors: Yari Amirhosein , Samadzadeh Anahita , Tabrizi-Nezhad Parinaz , MotieGhader Habib , Ebadi Zahra
Published: February 2024

Background As the third most common form of cancer worldwide, colorectal cancer (CRC) is a major health concern. The overall aim of this study is to reconstruct a network in order to identify novel biomarkers for diagnostic use, prospective Endocrine Disrupting Chemicals (EDCs) for preventative use, and novel medications for therapeutic use in early-stage CRC. Material and Methods The driver genes linked with early-stage CRC were selected from the gene expression omnibus (GEO) and DriverDB databases. Then with the help of WGCNA (Weighted gene co-expression network analysis), the R package, the co-expression network was reconstructed. Following that, modules were chosen for further analysis. The possible biomarkers and hub genes were identified using the Cytoscape software and the cancer genome atlas (TCGA) database for diagnostic purposes. Then probable EDCs were identified using the Comptox database and the EDC-GENE network was reconstructed and the EDCs with a high degree of risk for preventive purposes were identified. As a next step, the drug-gene network was reconstructed to find effective drugs for colorectal cancer in its early stages. Results The co-expression network was constructed using the 1108 driver genes mRNA expression values of 70 early-stage CRC and 12 healthy control samples. The clustering results show that the overlapping gene set is divided into 27 modules. In our study, five modules (indicated by the colors of dark green, dark orange, light cyan, royal blue, and purple) were identified according to the average linkage hierarchical clustering and Zsummaryless than 2. Then we find 17 high-degree genes of these modules as potential biomarkers for diagnostic issues. Moreover, we explored 25 potential high degrees of Endocrine Disrupting Chemicals that affect the main genes of each module for preventing purposes. Finally, we identified 27 potential high-degree drugs that affect the main genes of each module as treating aims. Then, these biomarkers, EDCs, and drugs that may be tested as a basis for future research were introduced. Conclusion The goal of this study was to identify candidate biomarkers for early detection, possible EDCs for prevention, and treatment agents for colorectal cancer. These biomarkers, EDCs, and drugs will help in the early detection, prevention, and treatment of colorectal cancer. Bioinformatics, computational biology, and systems biology methods were used to reach these claims; hence, they need to be tested in the lab. We anticipate that these results will provide important new insights into the etiology and early evolution of CRC and that they will inspire the development of novel approaches to treating this aggressive and lethal malignancy.
The early predictive roles of NLR and NE% in in-hospital mortality of septic patients
Authors: Wen Xiaoyue , Zhang Yujing , Song Chaoying , Shang You , Yuan Shiying , Zhang Jiancheng
Published: February 2024

Background: This study aimed to retrospectively investigate the early predictive value of inflammation-related parameters in-hospital mortality of septic patients.
Methods: We retrospectively recruited 606 patients from Wuhan Union Hospital from January 2009 to October 2022. The inflammation-related parameters including neutrophil-to-lymphocyte ratio (NLR), neutrophil percentage (NE%), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) in survivals and non-survivals on day 1, 2, 3 and 7 after hospitalization were collected and analyzed.
Results: NLR and NE% in non-survivals (n = 185) were significantly higher than those in survivals (n = 421). The area under the receiver operating characteristic curve (AUC) of NLR or NE% was 0.880 or 0.852 on day 1, 0.770 or 0.790 on day 2, 0.784 or 0.777 on day 3, and 0.732 or 0.741 on day 7. The optimal cut-off values of NLR or NE% for predicting in-hospital mortality were 10.769 or 87.70% on day 1, 17.544 or 90.69% on day 2, 14.395 or 85.00% on day 3, and 9.105 or 83.93% on day 7. The day 1, 2 and 3 NLR and NE% were significant predictors of in-hospital mortality in the Cox proportional hazards models.
Conclusions: NLR ≥ 10.769 and NE% ≥ 87.70% could be used early biomarkers for predicting in-hospital mortality of septic patients.
Trial registration: This trial was retrospectively registered at ClinicalTrials.gov (NCT05636202). Registered 08 November 2022.
Technical Sandbox for a Global Patient co-Owned Cloud (GPOC)
Authors: Davids Joe , ElSharkawy Mohamed , Ashrafian Hutan , Herlenius Eric , Lidströmer Niklas
Published: February 2024

Cloud-based personal health records increase globally. The GPOC series introduces the concept of a Global Patient co-Owned Cloud (GPOC) of personal health records. Here, we present the GPOC series’ technical sandbox. This to facilitate online research and testing of the concept and its security, encryption, movability, research potential, risks and structure. It has several protocols for homomorphic encryption, decentralisation, transfers and file management. The Sandbox is openly available online and tests authorisation, transmission, access control and integrity live. It invites all committed parties to test and improve the platform. Both individual patients, clinics, organisations and regulators are invited to test the concept. The GPOC Sandbox displays a co-ownership of personal health records. Here it is trisected between patients, clinics and clinicians. The patient can actively participate in research and control their health data. GPOC may influence global research and dissemination of artificial intelligence in healthcare. This may impact global health.
Repetitive Transcranial Magnetic Stimulation as a Treatment for Alzheimer’s Disease: A Randomized Placebo-Controlled Double-Blind Clinical Trial
Authors: Moussavi Zahra , Uehara Maria , Rutherford Grant , Lithgow Brian , Millikin Colleen , Wang Xikui , Saha Chandan , Mansouri Behzad , Omelan Craig , Fellows Lesley , Fitzgerald Paul B , Koski Lisa
Published: February 2024

We report results of a large multisite double-blind randomized trial investigating the short and long-term efficacy of repetitive transcranial magnetic stimulation (rTMS) applied to patients with Alzheimer’s disease (AD) at mild to moderate stages, in doses of either 2 or 4 weeks of treatment (5 days/week), whilst compared with 4 weeks of sham TMS. Randomization to treatment group was stratified based on age and severity. The objectives of this study were to: 1) investigate the efficacy of active rTMS versus sham, 2) investigate the effect of dose of treatment (2 or 4 weeks), and 3) investigate the length of benefits from treatment. The rTMS pulses (20 Hz, 30 pulses/train, 25 trains, 10-s intertrain interval) were applied serially to the left and right dorsolateral prefrontal cortex using neuro-navigation. We compared the primary outcome measure’s (ADAS-Cog) score changes from pre- to post-treatment, with assessments at baseline and 4 more times up to 6 months post-treatment. Data of 135 patients were analyzed. The mean total ADAS-Cog score at baseline did not differ between the active and sham treatment groups, nor across the three study sites. The overall results show significant cognitive improvement after treatment up to two months post-treatment with either sham or active coils. The results show both short and long-term benefits of active rTMS treatment but also show similar benefits for sham coil treatment of mild/moderate AD. We discuss this finding in the context of the existing literature on rTMS therapy for AD, as well as evidence of the sham coil’s potential to induce a low-level current in the brain.
The impact of weather forecast accuracy on the economic value of weather-sensitive industries
Authors: Shen Danna , Zuo zhengyu , Zhang Xiaofeng , Zhao Xinyu
Published: February 2024

This paper investigates the economic value of weather forecast accuracy in weather-sensitive industries. By analyzing statistical data from eight major industries across 31 provinces in China and meteorological data spanning from 2007 to 2021, we examine the sensitivity of industries to meteorological factors. The results reveal that improving weather forecast accuracy significantly enhances the output levels of all industries, with weather-sensitive industries experiencing a more pronounced impact. For every 1% increase in weather forecast accuracy, the output of non-sensitive industries will increase by around 1.5%, and that of weather-sensitive industries will increase by 2–3%. Moreover, we construct composite forecast indices and perform robustness tests to validate the findings. Based on the empirical results, we put forward policy recommendations to enhance the economic value of weather forecasting, including improving forecast technology and accuracy, broadening information dissemination channels, and promoting synergistic cooperation between meteorological departments and industries. These measures can empower decision-making, reduce risks, and improve efficiency across various sectors, ultimately contributing to sustainable economic development.
Assessing the ecotoxicity of commercial formulation based on Imidacloprid on the non-target freshwater planarian Girardia tigrina
Authors: de Oliveira Aline Arantes , Pedroso Thays Millena Alves , Rodrigues Andreia C. M. , Silva Daniela de Melo e , Sarmento Renato Almeida , Gravato Carlos , Marcionílio Suzana Maria de Oliveira , Santos Hellem Victoria Ribeiro dos , Dornelas Aline Silvestre Pereira , Saraiva Althiéris de Souza
Published: February 2024

Imidacloprid (IMI) is among the most frequently detected insecticides in freshwater ecosystems near agricultural areas where it affects not only target insects, but also other non-target organisms. This study aimed to investigate the acute and chronic toxicity of a commercial insecticide formulation that uses imidacloprid as the active ingredient (Imidagold 700 WG®) on the non-target planarian Girardia tigrina. The ecotoxicological tests performed evaluated the survival, locomotor velocity, regeneration, and reproduction of planarians. In the acute toxicity test, the organisms were exposed to various concentrations of IMI ranging from 50 mg a.i./L to 527 mg a.i./L alongside a control treatment (ASTM only). For the chronic effect toxicity evaluation, planarians were exposed to concentrations ranging from 100 to 1,600 µg a.i./L in addition to the control treatment (ASTM, only). The estimated LC50 at 24 and 48 hours for IMI was 114 and 94.29 mg a.i./L, showing low acute toxicity. However, decreased locomotor velocity and delayed regeneration of photoreceptors and auricles were observed for environmentally relevant concentrations equal or higher than 200 µg a.i./L. Reproduction was significantly impacted at the concentration of 200 µg a.i./L but not affected at higher concentrations, suggesting hormesis. Considering the planarians' importance in freshwater ecosystems and their position in the food chain, the detrimental effects induced by IMI may extend to freshwater communities and overall ecosystem functioning.
Ensemble Machine Learning Prediction Model for Ocular Refraction Using Partial Interferometry Measurements in Childhood
Authors: Kim Sa Ra , Kang Dong Hyun , Choe Gon Soo , Kim Dae Hee
Published: February 2024

To develop an ensemble machine learning prediction model for ocular refraction in childhood using partial interferometry measurements, Age, sex, cycloplegic refraction, and partial interferometry data collected within one month were obtained from patients aged 5 to 16 years. Four ensemble regression models were used to develop prediction models of spherical equivalents (SE) from the data. Root mean squared error (RMSE) was used to compare the accuracy among the models. That was compared with that of a previously developed multiple linear regression model.
4156 eyes from 1965 patients (50.3% female) were included. Mean age was 8.4 ± 2.3 years and mean SE was-1.01 ± 2.94 diopters(D). Mean axial length(Axl) was 23.63 ± 1.41 mm and mean keratometry reading of flat and steep axis was 43.58 ± 1.40 D. Developed models had accuracy of RMSE 0.800 to 0.829 D, which was superior to that of the conventional model (1.213 D). Simulations showed that female was associated more with myopia than that of male. Long eyes showed an increase in the myopic refraction per Axl.
Refractive errors can be calculated in the childhood with ocular biometric parameters using new models. Moreover, the models could simulate hypothetical relationships between ocular parameters and SE.
Dietary sucrose, sucralose and probiotic sweetener isomaltooligosaccharide divergently affect exercise induced weight loss and its associated skeletal muscle metabolism
Authors: Shi Lin , Liu Yuan , Duan Yongchang , Liu Tianqi , Zhang Baobao , Zhu Wanyu , Kang Jie , Zhang Kunru
Published: February 2024

Dietary sweeteners are highly favored by obese people who desire to lose weight and have been considered beneficial for weight maintenance and glucose control, but little is known whether they could affect exercise induced weight loss efficacy and its associated perturbations in skeletal muscles, a key organ playing critical roles glucose homeostasis. In the present study, we found daily drinking sucrose- and sucralose-sweetened water failed to influence the effect of exercise on weight reduction of high-fat-high-sucrose (HFHF) induced obese mice, but remarkably attenuated exercise induced improvements on skeletal muscle morphology, anti-fatigue capacity and glucose metabolism. Probiotic sweetener isomaltooligosaccharide (IMO) augmented beneficial effects of exercise on improving glucose metabolism and skeletal muscle morphology. Skeletal muscle transcriptomics analysis revealed that exercise regulated genes involved in fatty acid metabolism, insulin resistance, inflammation and mTOR signaling pathways. Drinking sucrose and sucralose increased mRNA expressions of Yap, IL-6, TNF-α, Fis1, Cytc, Myh2, Myh4, and protein expressions of IL-6, mTOR, FABP4 while lowered HIF1α, demonstrating their detrimental effects on counteracting exercise induced improvements in muscular functions and fatty acid metabolism. Consistent results were also validated in C2C12 skeletal muscle cells in vitro. Notably, we found that the exercised mice may be resistant to the excessive weight regain and its impaired glucose metabolism. For the first time, our study proved that both sucrose and sucralose could attenuate protection of exercise against muscular inflammation during the weight regain following weight loss. Collectively, our results reinforce that daily drinking of sucrose and sucralose-sweetened water counteracted exercise induced improvements on skeletal muscle metabolism and could be dietary factors favouring weight regain, while IMO to some extent synergistically augmented such benefits.
Skeletal muscle lncRNA profile associated with fatty acids in beef cattle
Authors: Salatta Bruna Maria , Muniz Maria Malane Magalhães , Fonseca Larissa Fernanda Simielli , Mota Lucio Flavio Macedo , Teixeira Caio de Souza , Frezarim Gabriela Bonfá , Serna-García Marta , Silva Danielly Beraldo dos Santos , Pereira Angélica Simone Cravo , Baldi Fernando , de Albuquerque Lucia Galvão
Published: February 2024

This study aimed to identify differentially expressed (DE) long non-coding RNAs (lncRNAs) in muscle tissue of Nellore cattle clustered by their fatty acid profile. Longissimus thoracis muscle samples from 48 young bulls were used to quantify fatty acid (FA) (myristic, palmitic, stearic, oleic, linoleic, conjugated linoleic (CLA), α-linolenic and the groups of saturated fatty acids (SFA), monounsaturated (MUFA), polyunsaturated (PUFA), ω3, ω6, PUFA/SFA ratio and ω6/ω3) and to generate RNA-Sequencing data for transcriptomic analyses. The K-means analysis was used to classify the 48 animals into three clusters based on their FA patterns. The C1 had significantly (p ≤ 0.05) higher PUFA, ω3, ω6, linoleic and α-linolenic content than C2 and C3. The proportion of MUFA, CLA and oleic in the C2 and C3 were significantly (p ≤ 0.05) higher in relation to C1, while C3 had significantly (p ≤ 0.05) higher proportions of ω6/ω3, SFA, myristic, palmitic and stearic proportion than C1 and C2. DE analyses were performed on three different comparisons, C1 vs. C2, C1 vs. C3 and C2 vs. C3, and 25, 28 and 22 DE lncRNAs (fold change > | 2 |, p-value < 0.01 and false discovery rate (FDR) < 0.05) were found, respectively. For C1 vs. C2 comparison, a new transcript “lncRNA_16456.3” was found and was interacted with the genes FAM126A (Family with sequence similarity 126 member A) and IL6 (Interleukin-6). These genes were enriched by GO biological function terms related to cellular response to lipid pathway. For the C1 vs. C3 comparison, the lncRNA "lncRNA_13894.1" interacting with the BNIP3 gene (BCL2/Adenovirus E1B 19 kDa protein-interacting protein 3) was enriched by GO biological function terms related to fat cell differentiation. For the C2 vs. C3 comparison, a new transcript “lncRNA_16618.6” interacted with genes involved in G protein-coupled receptors (GPCRs). Those genes play a crucial role in regulating lipolysis mediated by the cAMP signaling pathway and may be contributing to a higher PUFA fatty acid content in beef. For the three comparisons: C1 vs. C2, C1 vs. C3, and C2 vs. C3, the identified lncRNAs, including genic and intergenic (lincRNA were associated with genes affecting immune response, energy metabolism, lipid and FA metabolism, whose seem to play an essential role in the physiological processes related to meat quality. These findings provide new insights to better understand the biological mechanisms involved in gene regulation of FA composition in beef. This could be valuable for further investigation regarding interaction between lncRNAs and mRNAs and how these interactions may affect meat quality.
Update on the taxonomy of Clavulina in China II: description of four new species from Hainan Island.
Authors: Deng Peng Tao , Liu Xiangfen , Yan Jun , Chen Zuo-Hong , Zhang Ping
Published: February 2024

Four new species of Clavulina are described from specimens collected in the tropical rainforests of Hainan Island, China.Molecular phylogenetic analyses based on concatenated ITS+LSU+RPB2 sequences and morphological characters support the placement of these accessions within the genus Clavulina and their recognition as new species. Accordingly, Clavulina hainanensis sp. nov., C. pallidorosea sp. nov., C. tomentosa sp. nov., and C. eburnea sp. nov. are described and illustrated. We provide photographs, line drawings, and DNA sequences of the new species, and a key to all known Clavulina species in China. Holotypes of the new species are deposited in the Mycological Herbarium of Hunan Normal University (MHHNU).
Immune Response to COVID-19 Vaccination in Frail Patients
Authors: Liao Shao bing , Wu Liang , Li Shangjie , zheng Xueting , Xu Jiahao , Zhang Xiaoxia , Yin Mingjuan , Ni Jindong , Zhang Qiaoli , Yu Zuwei
Published: February 2024

Objective
This study sought to examine the immune response to COVID-19 vaccination in frail patients and the associated role of inflammatory factors in immune response to COVID-19 vaccination.
Methods
A prospective cohort study design was used to assess the effects of the COVID-19 vaccine in non-frail and frail elderly individuals following a frailty assessment. The immune response between the two elderly populations were compared using Poisson regression modeling. A nested case-control study in an elderly population was also performed, differentiating the case group from the control group based on COVID-19 vaccine efficacy. A logistic regression analysis was employed to examine the correlation between frailty-related inflammatory factors and COVID-19 vaccine efficacy.
Results
A total of 920 individuals participated in the study, with 598 (65%) belonging to the non-frail group and 322 (35%) to the frail group. The frail group exhibited a lower seropositivity rate than the non-frail group after adjusting for age, amount of vaccination shots, and vaccination type using modified Poisson regression (RR = 0.929, 95% CI: 0.891 − 0.968; P < 0.05). The Logistic regression analysis revealed that the positive group had lower levels of CXCL10 (OR = 0.951; CI: 0.907 − 0.997; P < 0.05) after correcting for covariate weakening.
Conclusion
The present findings indicate that frailty may have a negative impact on COVID-19 vaccine efficacy. The concentration of CXCL10 may affect COVID-19 vaccine efficacy by altering the inflammatory levels in elderly frail patients.