Integral effects of xenon: Inhibition of postovariectomy syndrome development in young women with cervical and breast cancers.
Authors: Popova Natalia N. , Shikhlyarova Alla I. , Frantsiyants Elena M. , Vashchenko Larisa N. , Kechedzhieva Emma E. , Babieva Stella M. , Kaplieva Irina V. , Neskubina Irina V. , Cheryarina Natalia D. , Trepitaki Lidia K. , Przhedetskiy Yuriy V. , Pozdnyakova Viktoria V. , Verenikina Ekaterina V. , Menshenina Anna P. , Surikova Ekaterina I. , Bandovkina Valeria A. , Rozenko Dmitry A. , Tumanyan Sergey V. , Kit Oleg I. 
Published: June 2022

e17515

Background: The development of deep postovariectomy disorders in young women with cervical and breast cancers is of extreme concern. They are associated with the suppression of the hypothalamic-pituitary-gonadal axis of regulation, estrogen involution, a sharp depression of the psycho-emotional state, and social distancing. In fact, these postovariectomy syndrome (POES) events are associated with low-reactivity stress syndrome. Our purpose included the transition of dominant stress into archetypes of anti-stress adaptive reactions under the influence of programmable exponential dose regimens of xenon-oxygen therapy (XOT) in the early period after the removal of the female reproductive organs. Methods: 123 patients of reproductive age diagnosed with cervical cancer pT1B2N0M0 and 24 patients with hormone-positive breast cancer pT2N1M0 and concomitant gynecological pathology underwent hysterectomy with oophorectomy and developed POES. All patients received a cycle (5 procedures) of low-dose inhalation XOT. The therapy consisted in a gradual increase in the percentage of xenon in the inhaled xenon-oxygen mixture with a reciprocal decrease in exposure time, an exponential regimen in the concentration range from 12–14% to 20–24% and exposure from 25 to 10 minutes. Blood levels of FSH, LH, estradiol, progesterone, and testosterone were measured by RIA (Immunotech, Czech Republic) before and after XOT. The psycho-emotional status was assessed by the generally accepted quality of life scales for cancer patients MOS-SF-36 and ESAS, the type of adaptive reactions was identified by Garkavi using the analysis of Schilling's leukogram, the severity of POES was determined by the menopausal index (MMI). Results: The POES manifestation and the dominance of acute stress were due to the inversion of hormonal metabolism - a decrease in the level of estradiol 487.3±52.4 and progesterone 1.8±0.1 relative to the initial levels 1017.9±83.4 nmol/L and 11.8±0.7 nmol/L, respectively, with an increase in FSH by 5.8 times, and LH by 2.4 times (p < 0.05). An accompanying XOT resulted in a significant MMI decrease (p < 0.05), training and calm activation reactions prevailed in 80% cases with harmonious changes in the regulation of hormonal processes and a clear regression of the acute estrogen deficiency (elevation of estradiol levels to 751.4±61.4 nmol/L and a decrease in FSH and LH by 1.5 and 2.1 times, respectively (p < 0.05)). MOS-SF-36 and ESAS assessment showed a significant decrease in pathological symptoms. Conclusions: XOT in the early postoperative period in cancer patients of the reproductive age with POES normalized their hormonal status, corrected functional disorders and improved their quality of life.