bluuebunny/crossref_metadata_2025 huggingface dataset:
Forecasting International Sugar Prices: A Bayesian Model Average Analysis
Authors: Amrouk El Mamoun , Heckelei Thomas
Published: April 2020

This paper examines the relative importance of key variables for the prediction of international sugar prices. Understanding movements in world sugar prices helps policy-makers and participants in the sugar value chain to formulate effective investment strategies and forecast the effects of market shocks more accurately. We combine a Bayesian model averaging (BMA) technique to address specification uncertainty with an out-of-sample analysis to evaluate price predictability. Results show that world sugar quotations are mostly influenced by their own dynamics, changes in international staple food prices, sugar production costs, and macroeconomic variables. The predictability of the BMA is found to be generally high, compared with a sample of benchmark time series approaches.
Kinder als „Stakeholder“ in Kindertageseinrichtungen [KiSte] – Studie zu den Sichtweisen der Kinder auf institutionelle Arrangements
Authors: Witton Tom , Gramelt Katja , Skalska Agata , Thole Werner
Published: April 2020

Das Forschungsprojekt Kinder als „Stakeholder“ in Kindertageseinrichtungen (KiSte) zielt auf die empirisch fundierte Erfassung der unterschiedlichen Sichtweisen von Kindern auf ihre Kindertageseinrichtung (Kita). Es wird davon ausgegangen, dass Kinder ihre eigenständigen Ideen zur Ausgestaltung der frühpädagogischen Arrangements haben, diese aber nicht durchgängig im Diskurs um die Weiterentwicklung frühpädagogischer Arrangements wahrgenommen werden. Da Kinder neben den Pädagog*innen die zentralen Akteur*innen und Gestalter*innen des pädagogischen und sozialen Alltags in Kitas sind, erhalten sie im Forschungsvorhaben die Möglichkeit, für sie Relevantes und Zeigenswertes zu filmen und in parallel verlaufenden Interviews ihre jeweiligen Deutungsweisen darzulegen.
Counting single cells and computing their heterogeneity: from phenotypic frequencies to mean value of a quantitative biomarker
Authors: Qian Hong , Cheng Yu‐Chen
Published: April 2020

This tutorial presents a mathematical theory that relates the probability of sample frequencies, of M phenotypes in an isogenic population of N cells, to the probability distribution of the sample mean of a quantitative biomarker, when the N is very large. An analogue to the statistical mechanics of canonical ensemble is discussed.
Two-Dimensional Tellurium: Progress, Challenges, and Prospects
Authors: Shi Zhe , Cao Rui , Khan Karim , Tareen Ayesha Khan , Liu Xiaosong , Liang Weiyuan , Zhang Ye , Ma Chunyang , Guo Zhinan , Luo Xiaoling , Zhang Han
Published: April 2020

Since the successful fabrication of two-dimensional (2D) tellurium (Te) in 2017, its fascinating properties including a thickness dependence bandgap, environmental stability, piezoelectric effect, high carrier mobility, and photoresponse among others show great potential for various applications. These include photodetectors, field-effect transistors, piezoelectric devices, modulators, and energy harvesting devices. However, as a new member of the 2D material family, much less known is about 2D Te compared to other 2D materials. Motivated by this lack of knowledge, we review the recent progress of research into 2D Te nanoflakes. Firstly, we introduce the background and motivation of this review. Then, the crystal structures and synthesis methods are presented, followed by an introduction to their physical properties and applications. Finally, the challenges and further development directions are summarized. We believe that milestone investigations of 2D Te nanoflakes will emerge soon, which will bring about great industrial revelations in 2D materials-based nanodevice commercialization.
Exploration of teachers’ personal practical knowledge for teaching controversial public issues in elementary school classrooms
Authors: Hung Yu-Han
Published: April 2020

This study explores teachers’ personal practical knowledge and curricular-instructional gatekeeping as they relate to the teaching of controversial issues in public elementary school settings, particularly the issue of immigration. The study took place in the urban setting of Houston and, using a case study design, documented how three elementary school teachers made curricular-instructional decisions by making use of their personal practical knowledge. Findings illuminate that personal practical knowledge plays a role in teacher's curricular-instructional gate keeping in socially divisive contexts. And, the findings indicate that these three elementary school teachers make curricular-instructional decisions to effectively address controversial public issues in their classrooms through curriculum choosing, assignments creating, and conflict dialogue building.
Fiddlehead Fern Poisoning: A Case Report
Authors: Dhir S. Bryn
Published: April 2020

Outdoor enthusiasts are at a high risk of poisonous side effects after ingestion of wild and raw edible fiddlehead ferns, such as the ostrich fern ( Matteuccia struthiopteris) and bracken ( Pteridium genus) species, in the United States and Canada. The acute onset of nonlethal side effects manifests with gastrointestinal signs and symptoms and can last from 24 h up to 3 d. This case report is the first to outline the presentation of ingestion of a wild fiddlehead plant in the Carrabassett Valley in Maine, as well as the supportive management for this concerning and self-limiting illness.
Successful Defibrillation at a Core Temperature of 18.2 Degrees Celsius
Authors: Kosiński Sylweriusz , Drzewiecka Anna , Pasquier Mathieu , Gołba Krzysztof S. , Podsiadło Paweł , Drwiła Rafał , Darocha Tomasz
Published: April 2020

Both the temperature at which defibrillation can be effectively used and how often it should be repeated in severe accidental hypothermia have not been definitely established. Current recommendations are based mainly on expert opinion and suggest withholding defibrillation after 3 shocks when the core temperature is below 30°C (86°F). However, growing evidence supports the effectiveness of defibrillation in patients with a core temperature below 30°C (86°F). We present a case of successful defibrillation of a 54-y-old, severely hypothermic patient with a core temperature of 18.2°C (64.8°F). The shock was delivered automatically by an implanted cardioverter-defibrillator shortly after the implementation of extracorporeal rewarming. The patient survived and was discharged from the hospital neurologically intact. It might be reasonable to consider defibrillation attempts in severely hypothermic patients despite current guidelines to the contrary. Increasing coronary perfusion using extracorporeal circulation may result in a better response to defibrillation.
Aviation Sports Crashes in the Austrian Mountains: A 10-Year Retrospective Study
Authors: Ströhle Mathias , Woyke Simon , Wallner Bernd , Brodmann Maeder Monika , Brugger Hermann , Paal Peter
Published: April 2020

Introduction

We aimed to describe the epidemiology and injury patterns of aviation sports crashes in the Austrian mountains and identify risk factors.

Methods

In this retrospective cohort study, out-of-hospital data on patients who sustained crashes when participating in aviation sports from January 1, 2006 through December 31, 2015 were assessed. The out-of-hospital data were merged with in-hospital data obtained from Innsbruck Medical University Hospital.

Results

A total of 2037 persons were involved in 1856 aviation sports crashes. Data on 126 in-hospital patients were available. Wind and pilot error were the most common causes. Most injuries occurred in paragliders (n=111, 88%). Most commonly, paragliders sustained injuries to the lumbar spine and hang gliders to the thoracic spine. Rescue operations were undertaken mainly by helicopter emergency medical services (n=87, 69%) or combined rescue forces (ground and helicopter, n=100, 79%.). The Injury Severity Score was 15±15, with a peak in patients with isolated injuries of the lower extremities (n=38, 32%) and a second peak in patients with multiple trauma (n=44, 35%).

Conclusions

In the Austrian mountains, wind and pilot errors are the most common causes of aviation crashes. Aviation sports crashes frequently resulted in severe injuries and multiple trauma. The lumbar spine is particularly at risk in paragliders, whereas the thoracic spine is commonly affected in hang gliders. Injuries frequently caused long-term paralysis and limitations in quality of life. To minimize long-term consequences and save lives, skilled and well-equipped teams may be beneficial to provide effective on-site care and safe transportation to a trauma center.
Review of Scorpion Stings and Snakebites Treated by the French Military Health Service During Overseas Operations Between 2015 and 2017
Authors: Bomba Aurore , Favaro Pascal , Haus Rachel , Aigle Luc , Jean François-Xavier , Dauphin Isabelle , Guigon Pierre , Fontaine Bruno , Puidupin Marc , Demoncheaux Jean-Paul , Larréché Sébastien
Published: April 2020

Introduction

Depending on their theatre of operation, French soldiers may potentially be exposed to scorpion stings and snakebites. Following the recommendations of a French military health service (FMHS) technical committee for envenomation, the FMHS provides antivenoms appropriate to each deployment. This work aimed to evaluate this risk of envenomation and to assess the antivenoms used by the FMHS in operational theatres since the creation of this committee in 2015.

Methods

Cases were identified based on a review of temporary authorization of use application forms for the use of antivenom. Data were collected retrospectively from these forms, and prescribing physicians were contacted for any missing data.

Results

Between 2015 and 2017, 28 requests for temporary authorization of use were identified: 19 for Scorpifav (Sanofi-Pasteur, Lyon, France) and 9 for Fav-Afrique (Sanofi-Pasteur). The FMHS treated 15 soldiers and 4 civilians for scorpion envenomation with Scorpifav: 15 in Mali, 3 in Chad, and 1 in Niger. Systemic signs were observed in 7 patients. Two soldiers and 7 civilians were treated with Fav-Afrique for ophidian envenomation: 5 in Djibouti, 3 in Mali, and 1 in the Republic of Côte d’Ivoire. These 28 patients were treated without sequelae. Other than moderate erythema that resolved with an antihistamine, no adverse effects were reported. Medical evacuation to France was unnecessary.

Conclusions

This study shows that the risk of envenomation for soldiers on deployment is low but real. Antivenoms used by the FMHS were efficient and well tolerated, preserving the operational capacity of deployed troops.
Using volunteers to improve the experience of older patients in the emergency department
Authors: Ellis Brittany , Melady Don , Foster Nicoda , Sinha Samir , Lau Vicki , Saraga Stephanie , McLeod Shelley L.
Published: April 2020

Objectives

The Maximizing Aging Using Volunteer Engagement in the Emergency Department (MAUVE + ED) program connects specially trained volunteers with older patients whose personal and social needs are not always met within the busy ED environment. The objective of this study was to describe the development and implementation of the MAUVE + ED program.

Methods

Volunteers were trained to identify and approach older patients at risk for adverse outcomes, including poor patient experience, and invite such patients to participate in the program. The program is available to all patients >65 years, and those with confusion, patients who were alone, those with mobility issues, and patients with increased length of stay in the ED. Volunteers documented their activities after each patient encounter using a standardized paper-based data collection form.

Results

Over the program's initial 6-month period, the MAUVE + ED volunteers reported a total of 896 encounters with 718 unique patients. The median time (interquartile range [IQR]) a MAUVE volunteer spent with a patient was 10 minutes (IQR = 5, 20), with a range of 1 to 130 minutes. The median number of patients seen per shift was 7 (IQR = 6, 9), with a range of 1 to 16 patients per shift. The most common activities the volunteer assisted with were therapeutic activities/social visits (n = 859; 95.9%), orientation activities (n = 501; 55.9%), and hydration assistance (n = 231; 25.8%). The least common were mobility assistance (n = 36; 4.0%), and vision/hearing assistance (n = 13; 1.5%).

Conclusions

Preliminary data suggest the MAUVE + ED volunteers were able to provide additional care to older adults and their families/carers in the ED.
Recent Developments in Calibration for Archaeological and Environmental Samples
Authors: van der Plicht J , Bronk Ramsey C , Heaton T J , Scott E M , Talamo S
Published: April 2020

The curves recommended for calibrating radiocarbon (14C) dates into absolute dates have been updated. For calibrating atmospheric samples from the Northern Hemisphere, the new curve is called IntCal20. This is accompanied by associated curves SHCal20 for the Southern Hemisphere, and Marine20 for marine samples. In this “companion article” we discuss advances and developments that have led to improvements in the updated curves and highlight some issues of relevance for the general readership. In particular the dendrochronological based part of the curve has seen a significant increase in data, with single-year resolution for certain time ranges, extending back to 13,910 calBP. Beyond the tree rings, the new curve is based upon an updated combination of marine corals, speleothems, macrofossils, and varved sediments and now reaches back to 55,000 calBP. Alongside these data advances, we have developed a new, bespoke statistical curve construction methodology to allow better incorporation of the diverse constituent records and produce a more robust curve with uncertainties. Combined, these data and methodological advances offer the potential for significant new insight into our past. We discuss some implications for the user, such as the dating of the Santorini eruption and also some consequences of the new curve for Paleolithic archaeology.
Ileal and hindgut fermentation in the growing pig fed a human-type diet
Authors: Hoogeveen Anna M. E. , Moughan Paul J. , de Haas Edward S. , Blatchford Paul , McNabb Warren C. , Montoya Carlos A.
Published: April 2020

Dietary fibre fermentation in humans and monogastric animals is considered to occur in the hindgut, but it may also occur in the lower small intestine. This study aimed to compare ileal and hindgut fermentation in the growing pig fed a human-type diet using a combined in vivo/in vitro methodology. Five pigs (23 (sd 1·6) kg body weight) were fed a human-type diet. On day 15, pigs were euthanised. Digesta from terminal jejunum and terminal ileum were collected as substrates for fermentation. Ileal and caecal digesta were collected for preparing microbial inocula. Terminal jejunal digesta were fermented in vitro with a pooled ileal digesta inoculum for 2 h, whereas terminal ileal digesta were fermented in vitro with a pooled caecal digesta inoculum for 24 h. The ileal organic matter fermentability (28 %) was not different from hindgut fermentation (35 %). However, the organic matter fermented was 66 % greater for ileal fermentation than hindgut fermentation (P = 0·04). Total numbers of bacteria in ileal and caecal digesta did not differ (P = 0·09). Differences (P < 0·05) were observed in the taxonomic composition. For instance, ileal digesta contained 32-fold greater number of the genus Enterococcus, whereas caecal digesta had a 227-fold greater number of the genus Ruminococcus. Acetate synthesis and iso-valerate synthesis were greater (P < 0·05) for ileal fermentation than hindgut fermentation, but propionate, butyrate and valerate synthesis was lower. SCFA were absorbed in the gastrointestinal tract location where they were synthesised. In conclusion, a quantitatively important degree of fermentation occurs in the ileum of the growing pig fed a human-type diet.
Myocardial infarction: Economic, health, and social impacts on informal caregivers
Authors: Rabier Hugo , Serrier Hassan , Schott Anne-Marie , Mewton Nathan , Margier Jennifer , Barral Marine , Dalaudiere Jessica , Fares Asma , Grguric Gwen , Guerre Pascale , Julien Christell , Viprey Marie , Ovize Michel , Nighoghossian Norbert , Duclos Antoine , Colin Cyrille
Published: April 2020

Objectives

The aim of the study was to measure the economic impact of informal care (IC) on caregivers assisting myocardial infarction (MI) survivors in France. Health and social impacts were also described.

Methods

Data from the prospective 2008 Health and Disabilities Households Survey (Enquête Handicap-Santé), carried out among the French general population, were used to obtain information about patients with MI and their informal caregivers. To estimate the approximate monetary value of IC, three methods were used: the proxy good method, opportunity cost method (OCM), and contingent valuation method (CVM). A multivariate analysis was performed to determine the associations of the IC duration and the existence of professional care with the health indicators stated by caregivers.

Results

The analysis included data from 147 caregivers. The mean value of IC ranged from €9,679 per year using the CVM to €11,288 per year using the OCM (p> .05). The mean willingness to pay for an additional hour of IC was €10.9 (SD = 8.3). A total of 46.2 percent of caregivers reported that IC negatively affected theirs physical condition, and 46.3 percent reported that it negatively affected their psychological health. In addition, 40.1 percent declared that caregiving activity made them anxious and 38.8 percent stated they felt alone. Associations were identified between the duration of IC and feeling the need to be replaced, feeling alone and making sacrifices (p< .05).

Conclusions

Informal caregiver burden may be recognized in health technology assessment in order not to underestimate the cost of strategies and to facilitate the comparability of cost-effectiveness outcomes between studies.
A Science Show Debate: How the Stasi Staged Revisionism
Authors: Düppe Till
Published: April 2020

In the early years of the East German Democratic Republic, in particular after Khrushchev's speech breaking with Stalinism, there was hope among leading economists that new reforms would usher in a truly democratic socialist economy. The newly-founded Institute for Economics at the Academy of Sciences, under the leadership of Friedrich Behrens, put forward ideas that the party soon labelled ‘revisionist’. This article reconstructs the dismantling of this group of reformist economists using detailed documents of the secret police, the Stasi. I demonstrate how the Stasi staged a show debate analogous to the known show trials under Stalin. In spite of its forced character the show debate allowed the party to both resist reform and claim their policies to be a scientific undertaking.
Heterogeneous Response of Chemotherapy-Related Cognitive Decline in Patients with Breast Cancer: A Prospective Study
Authors: Schrauwen Wim , Van de Cavey Joris , Vingerhoets Guy , Vanheule Stijn , Van den Broecke Rudy , Denys Hannelore
Published: April 2020

Objective:

A significant proportion of adjuvant-treated breast cancer patients experience cognitive decline, challenging the person’s ability to return to normal activities after treatment. However, not every patient experiences cognitive problems, and even in patients with impairments, determining clinically important cognitive decline remains challenging. Our objective was to explore differences in neuropsychological performance following adjuvant chemotherapy (CT) in patients with breast cancer.

Method:

We conducted a prospective observational study in an Oncology Breast Clinic and assessed neuropsychological performance before and after adjuvant CT and in non-CT-treated women with breast cancer and healthy controls (HCs). Standardised between-group differences and regression-based change scores were calculated.

Results:

CT-treated patients (n= 66) performed significantly different from non-CT-treated patients (n= 39) and HCs (n= 56). There was a significant effect on verbal fluency (p= .0013). CT performed significantly worse than non-CT and HC [effect size (ES) = .89,p< .001 and ES = .61,p≤ .001, respectively] and from HCs with regard to proactive interference (ES = .62,p≤ .001). Regression-based scores revealed more severe cognitive decline in the CT-treated group [24.24% (16/66)] than in the non-CT-treated group [15.20% (6/39)] and HC group [7.14% (4/56)]. Patients who underwent CT and showed cognitive decline were less educated and older, with significantly lower baseline scores.

Conclusions:

CT-treated patients showed more vulnerability on cognitive control and monitoring than non-CT-treated breast cancer patients and HCs. Older patients with less education and lower baseline cognitive performance represent a group at risk for cognitive decline following CT. Identification of patients at risk for decline could improve targeted support and rehabilitation.
Metabolic syndrome and its relation to dietary patterns among a selected urbanised and semi-urbanised Tibetan population in transition from nomadic to settled living environment
Authors: Peng Wen , Liu Yan , Malowany Maureen , Chen Hongru , Su Xiaodong , Liu Yongnian
Published: April 2020

Objective:

To explore the scope of metabolic syndrome (MetS) and its relationship to the major dietary patterns among an urbanised and semi-urbanised Tibetan population in transition from nomadic to settled settings.

Design:

Cross-sectional.

Setting:

Community-based.

Participants:

Urbanised and semi-urbanised Tibetan adults (n 920, aged 18–90 years), who have moved from nomadic to settled living environments, answered questionnaires on food consumption frequency and lifestyle characteristics through structured face-to-face interviews and completed anthropometric measurement and metabolic biomarker tests.

Results:

MetS prevalence was 30·1 % in males and 32·1 % in females. Low HDL-cholesterol and central obesity were the leading metabolic abnormalities (86·3 and 55·8 %, respectively). Three major dietary patterns – urban, western and pastoral – were identified. Beef/mutton was an important food group for all three identified dietary patterns. In addition, the urban dietary pattern was characterised by frequent consumption of vegetables, tubers/roots and refined carbohydrates; the western pattern was characterised by sweetened drinks, snacks and desserts; and the pastoral pattern featured tsamba (roasted Tibetan barley), Tibetan cheese, butter tea/milk tea and whole-fat dairy foods. Individuals in the highest quintile of urban dietary pattern scores were found to be at a higher risk of developing MetS (OR 2·43, 95 % CI 1·41, 4·18) and central obesity (OR 1·91, 95 % CI 1·16, 3·14) after controlling for potential confounders.

Conclusions:

MetS was common among urbanised and semi-urbanised Tibetan adult population in transition. The urban dietary pattern, in particular, was a risk factor for MetS. To prevent MetS, nutrition interventions need to be tailored to address the variety of local diet patterns to promote healthy eating.
“Natural” Climate Solutions Could Speed Up Mitigation, With Risks. Additional Options Are Needed.
Authors: Crusius John
Published: April 2020

Mitigation of climate change by intentionally storing carbon in tropical forests, soils, and wetlands and by reducing greenhouse gas fluxes from these settings has been promoted as rapidly deployable and cost‐effective. This approach, sometimes referred to as “natural climate solutions,” could keep post‐industrialization warming below 1.5 °C, when coupled with reductions in fossil fuel emissions, as confirmed here with a simple numerical model of future emissions. However, such mitigation could cease in response to changes in future climate, land use, or natural resource policies, or there could be CO2 released from reservoirs of stored carbon. Model simulations suggest cumulative emissions could be similar, under scenarios where carbon storage ceases, or stored carbon is released, to emissions expected in the absence of any natural mitigation. If climate change is to be minimized, no‐regrets approaches to natural mitigation should be considered (e.g., by reducing deforestation), as emissions targets that could limit warming to 1.5 °C cannot be met without mitigation of this magnitude. However, additional mitigation options should also be evaluated that can reduce CO2 emissions and remove CO2 from the air (and store it permanently).
Simulation of the 2018 Global Dust Storm on Mars Using the NASA Ames Mars GCM: A Multitracer Approach
Authors: Bertrand T. , Wilson R. J. , Kahre M. A. , Urata R. , Kling A.
Published: April 2020

Global dust storms are the most thermodynamically significant dust events on Mars. The most recent of these events occurred in 2018. Although it was monitored by several spacecraft in orbit and on the surface, many questions remain regarding its onset, expansion and decay. Here, we model the 2018 event with the National Aeronautics and Space Administration (NASA) Ames Mars Global Climate Model in order to better understand the evolution of the storm. Our results highlight a mechanism for the expansion of the storm: the initial equatorial regional storm creates a zonal atmospheric temperature gradient causing strong equatorial eastward winds and thus rapid eastward transport of dust and subsequent lifting. The model shows rapid back and forth transfer of dust between western and eastern hemispheres reservoirs, which may also play an important role in the storm's development through teleconnections involving replenishment of surface dust. The model also shows that gigantic dust plumes occur during the storm's mature phase, injecting dust up to 80 km. Our analysis shows that their upward motion in the atmosphere is due to the ascending branches of Hadley cells, whose intensity is reinforced during the storm with increasing dustiness. We show that the global atmospheric warming during the storm cause vapor and water ice clouds to migrate to higher altitudes, in line with recent observations. Finally, we find that the choice of effective radius for the lifted dust particle size distribution impacts the intensity of the Hadley circulation and could explain some of the differences obtained between model results and observations.
A Multicentury Perspective on the Relative Influence of Seasonal Precipitation on Streamflow in the Missouri River Headwaters
Authors: Frederick S. E. , Woodhouse C. A.
Published: April 2020

The impacts of warming temperatures and declining snowpack on seasonal water yields in the Missouri River Headwaters are not well understood, revealing a gap in our understanding of regional hydroclimate and drivers of streamflow within the Upper Missouri River basin. This study presents the first annually resolved tree‐ring reconstruction of spring precipitation for the Missouri River Headwaters. This reconstruction along with existing tree‐ring reconstructions of 1 April snow water equivalence (SWE) and water year streamflow are used to detect variable influences of winter and spring precipitation on streamflow over past centuries, and relative to the modern period. The results suggest that spring precipitation has been a more consistent influence on water year streamflow in the Missouri River Headwaters over past centuries than winter snowpack. The strong relationship between 1 April SWE values and water year streamflow in the Missouri River Headwaters observed over much of the 20th century is not found to be a consistent feature of these multicentury paleorecords. Instead, the climatic influences on streamflow within the Missouri River Headwaters are likely more variable than 20th‐century instrumental records indicate.
Mountain Streams Exhale More Than Their Share of CO2
Authors: Cartier Kimberly
Published: April 2020

Streams that flow down mountainsides are more turbulent than those that run along forest floors, which leads to faster gas exchange between water and air.
Association between sedentary behavior and the risk of dementia: a systematic review and meta-analysis
Authors: Yan Shijiao , Fu Wenning , Wang Chao , Mao Jing , Liu Bing , Zou Li , Lv Chuanzhu
Published: April 2020

An increasing number of original studies suggest that sedentary behavior is associated with the risk of dementia, but the results remain inconsistent and inconclusive. In this meta-analysis, we analyzed available observational epidemiological evidence to identify the association between sedentary behavior and the risk of dementia. We searched PubMed and Embase from their inception to March 2019 to identify observational studies examining the association between sedentary behavior and risk of dementia. Two authors independently extracted data and assessed study quality using predefined criteria. The Q statistics and I² methods were used to test for heterogeneity. The publication bias of the included studies was also estimated using Begg’s and Egger’s tests. We identified 18 relevant cohort studies involving 250,063 participants and 2269 patients with dementia. Pooled result showed that sedentary behavior was significantly associated with increased risk of dementia (RR = 1.30; 95% CI: 1.12–1.51). In addition, subgroup analyses by state, and controlling for the concomitant effects of age, sex, education were conducted for the increase of dementia risk, relating to sedentary, respectively. In general, these subgroup analyses showed no statistically significant differences. The results of our meta-analysis suggested that sedentary behavior was independently associated with a significantly increased risk of dementia, which might have important implications in conducting etiological studies for dementia and developing strategies for dementia prevention.
Alternative macrophage polarisation associated with resistance to anti-PD1 blockade is possibly supported by the splicing of FKBP51 immunophilin in melanoma patients
Authors: Troiani Teresa , Giunta Emilio Francesco , Tufano Martina , Vigorito Vincenza , Arrigo Paolo D’ , Argenziano Giuseppe , Ciardiello Fortunato , Romano Maria Fiammetta , Romano Simona
Published: April 2020

Background

FKBP51 immunophilin is abundantly expressed by immune cells. Co-inhibitory immune receptor signalling generates the splicing isoform FKBP51s. Tregs stained by FKBP51s are increased in melanoma patients and their counts are associated with anti-CTLA-4 response. An expansion of FKBP51s+PD-L1+ monocytes was measured in a group of non-responding patients to anti-CTLA-4. The aim of this work was to confirm the predictive value of response of FKBP51s+Tregs in a cohort of patients undergoing anti-PD1 treatment and shed light on a monocyte subset co-expressing PD-L1/FKBP51s.

Methods

Co-cultures of organoids and autologous lymphocytes were used to confirm that tumour T-cell interaction can induce FKBP51s. PBMC immunophenotype and flow cytometry served to assess and monitor FKBP51s+Treg and FKBP51s+PD-L1+ monocytes in 22 advanced melanoma patients treated with anti-PD1. Silencing and overexpression of FKBP51s in human macrophages served to address the protein role in the tolerant macrophages’ behaviour.

Results

FKBP51s+Tregs count was increased in responders and had a prognostic value. Non-responders showed an early increase in FKBP51s+ PD-L1+ monocytes during anti-PD1 treatment. Manipulation of FKBP51s modulated the macrophage–phenotype, with forced protein expression promoting aspects associated with tolerance.

Conclusions

FKBP51s may guide in the selection and monitoring of melanoma patient candidates to immune-checkpoint-targeted therapy. Manipulation of FKBP51s may overcome resistance.
Biological weed control to relieve millions from Ambrosia allergies in Europe
Authors: Schaffner Urs , Steinbach Sandro , Sun Yan , Skjøth Carsten A. , de Weger Letty A. , Lommen Suzanne T. , Augustinus Benno A. , Bonini Maira , Karrer Gerhard , Šikoparija Branko , Thibaudon Michel , Müller-Schärer Heinz
Published: April 2020

Invasive alien species (IAS) can substantially affect ecosystem services and human well-being. However, quantitative assessments of their impact on human health are rare and the benefits of implementing IAS management likely to be underestimated. Here we report the effects of the allergenic plant Ambrosia artemisiifolia on public health in Europe and the potential impact of the accidentally introduced leaf beetle Ophraella communa on the number of patients and healthcare costs. We find that, prior to the establishment of O. communa, some 13.5 million persons suffered from Ambrosia-induced allergies in Europe, causing costs of Euro 7.4 billion annually. Our projections reveal that biological control of A. artemisiifolia will reduce the number of patients by approximately 2.3 million and the health costs by Euro 1.1 billion per year. Our conservative calculations indicate that the currently discussed economic costs of IAS underestimate the real costs and thus also the benefits from biological control.
A Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extension
Authors: Popkova Anna , Stone Orrin J. , Chen Lin , Qin Xiang , Liu Chang , Liu Jiaying , Belguise Karine , Montell Denise J. , Hahn Klaus M. , Rauzi Matteo , Wang Xiaobo
Published: April 2020

Actomyosin supracellular networks emerge during development and tissue repair. These cytoskeletal structures are able to generate large scale forces that can extensively remodel epithelia driving tissue buckling, closure and extension. How supracellular networks emerge, are controlled and mechanically work still remain elusive. During Drosophila oogenesis, the egg chamber elongates along the anterior-posterior axis. Here we show that a dorsal-ventral polarized supracellular F-actin network, running around the egg chamber on the basal side of follicle cells, emerges from polarized intercellular filopodia that radiate from basal stress fibers and extend penetrating neighboring cell cortexes. Filopodia can be mechanosensitive and function as cell-cell anchoring sites. The small GTPase Cdc42 governs the formation and distribution of intercellular filopodia and stress fibers in follicle cells. Finally, our study shows that a Cdc42-dependent supracellular cytoskeletal network provides a scaffold integrating local oscillatory actomyosin contractions at the tissue scale to drive global polarized forces and tissue elongation.
Circadian regulation of mitochondrial uncoupling and lifespan
Authors: Ulgherait Matt , Chen Anna , McAllister Sophie F. , Kim Han X. , Delventhal Rebecca , Wayne Charlotte R. , Garcia Christian J. , Recinos Yocelyn , Oliva Miles , Canman Julie C. , Picard Martin , Owusu-Ansah Edward , Shirasu-Hiza Mimi
Published: April 2020

Because old age is associated with defects in circadian rhythm, loss of circadian regulation is thought to be pathogenic and contribute to mortality. We show instead that loss of specific circadian clock components Period (Per) and Timeless (Tim) in male Drosophila significantly extends lifespan. This lifespan extension is not mediated by canonical diet-restriction longevity pathways but is due to altered cellular respiration via increased mitochondrial uncoupling. Lifespan extension of per mutants depends on mitochondrial uncoupling in the intestine. Moreover, upregulated uncoupling protein UCP4C in intestinal stem cells and enteroblasts is sufficient to extend lifespan and preserve proliferative homeostasis in the gut with age. Consistent with inducing a metabolic state that prevents overproliferation, mitochondrial uncoupling drugs also extend lifespan and inhibit intestinal stem cell overproliferation due to aging or even tumorigenesis. These results demonstrate that circadian-regulated intestinal mitochondrial uncoupling controls longevity in Drosophila and suggest a new potential anti-aging therapeutic target.
Multi-Agent Thompson Sampling for Bandit Applications with Sparse Neighbourhood Structures
Authors: Verstraeten Timothy , Bargiacchi Eugenio , Libin Pieter J. K. , Helsen Jan , Roijers Diederik M. , Nowé Ann
Published: April 2020

Multi-agent coordination is prevalent in many real-world applications. However, such coordination is challenging due to its combinatorial nature. An important observation in this regard is that agents in the real world often only directly affect a limited set of neighbouring agents. Leveraging such loose couplings among agents is key to making coordination in multi-agent systems feasible. In this work, we focus on learning to coordinate. Specifically, we consider the multi-agent multi-armed bandit framework, in which fully cooperative loosely-coupled agents must learn to coordinate their decisions to optimize a common objective. We propose multi-agent Thompson sampling (MATS), a new Bayesian exploration-exploitation algorithm that leverages loose couplings. We provide a regret bound that is sublinear in time and low-order polynomial in the highest number of actions of a single agent for sparse coordination graphs. Additionally, we empirically show that MATS outperforms the state-of-the-art algorithm, MAUCE, on two synthetic benchmarks, and a novel benchmark with Poisson distributions. An example of a loosely-coupled multi-agent system is a wind farm. Coordination within the wind farm is necessary to maximize power production. As upstream wind turbines only affect nearby downstream turbines, we can use MATS to efficiently learn the optimal control mechanism for the farm. To demonstrate the benefits of our method toward applications we apply MATS to a realistic wind farm control task. In this task, wind turbines must coordinate their alignments with respect to the incoming wind vector in order to optimize power production. Our results show that MATS improves significantly upon state-of-the-art coordination methods in terms of performance, demonstrating the value of using MATS in practical applications with sparse neighbourhood structures.
Continuous-variable source-device-independent quantum key distribution against general attacks
Authors: Zhang Yichen , Chen Ziyang , Weedbrook Christian , Yu Song , Guo Hong
Published: April 2020

The continuous-variable quantum key distribution with entanglement in the middle, a semi-device-independent protocol, places the source at the untrusted third party between Alice and Bob, and thus has the advantage of high levels of security with the purpose of eliminating the assumptions about the source device. However, previous works considered the collective-attack analysis, which inevitably assumes that the states of the source has an identical and independently distributed (i.i.d) structure, and limits the application of the protocol. To solve this problem, we modify the original protocol by exploiting an energy test to monitor the potential high energy attacks an adversary may use. Our analysis removes the assumptions of the light source and the modified protocol can therefore be called source-device-independent protocol. Moreover, we analyze the security of the continuous-variable source-device-independent quantum key distribution protocol with a homodyne-homodyne structure against general coherent attacks by adapting a state-independent entropic uncertainty relation. The simulation results indicate that, in the universal composable security framework, the protocol can still achieve high key rates against coherent attacks under the condition of achievable block lengths.
Aging affects gain and internal noise in the visual system
Authors: Yan Fang-Fang , Hou Fang , Lu Hongyu , Yang Jia , Chen Lijun , Wu Yifan , Chen Ge , Huang Chang-Bing
Published: April 2020

Visual functions decline with age, but how aging degrades visual functions remains controversial. In the current study, the mechanisms underlying age-related visual declines were examined psychophysically. We developed an efficient method to quickly explore contrast sensitivity as a function of nine spatial frequencies at three levels of external noise in both young and old subjects. Fifty-two young and twenty-six old subjects have been screened for ophthalmological and mental diseases and participated in the experiment. Contrast sensitivity varied significantly with spatial frequency, age, and level of external noise. By adopting a nonlinear observer model, we decomposed contrast sensitivity into inefficiencies in internal additive noise, internal multiplicative noise, perceptual template gain, and/or system non-linearity. Model analysis revealed that aging impacts both internal additive noise and perceptual template gain, and such age-related degradation is tuned to spatial frequency, which is also a good predictor to discriminate old from young. The quick characterization of contrast sensitivity functions at different noise levels and the accompanying analysis developed in the current study may have profound application in other clinical populations.
Early Recognition of the Preference for Exclusive Breastfeeding in Current China: A Prediction Model based on Decision Trees
Authors: Wang Yiting , Shan Chunjian , Zhang Yingying , Ding Lei , Wen Juan , Tian Yingying
Published: April 2020

Exclusive breastfeeding (EBF) is affected by multiple risk factors. Therefore, it is difficult for clinical professionals to identify women who will not practice EBF well and provide subsequent medical suggestions and treatments. This study aimed to apply a decision tree (DT) model to predict EBF at two months postpartum. The socio-demographic, clinical and breastfeeding parameters of 1,141 breastfeeding women from Nanjing were evaluated. Decision tree modelling was used to analyse and screen EBF factors and establish a risk assessment model of EBF. The Chinese version of the Breastfeeding Self-Efficacy Scale (CV-BSES) score, early formula supplementation, abnormal nipples, mastitis, neonatal jaundice, cracked or sore nipples and intended duration of breastfeeding were significant risk factors associated with EBF in the DT model. The accuracy, sensitivity and specificity of the DT model were 73.1%, 75.5% and 66.3%, respectively. The DT model showed similar or better performance than the logistic regression model in assessing the risk of early cessation of EBF before two months postpartum. The DT model has potential for application in clinical practice and identifies high-risk subpopulations that need specific prevention.
The insufficiency of circulating miRNA and DNA as diagnostic tools or as biomarkers of treatment efficacy for Onchocerca volvulus
Authors: Macfarlane Cara L. , Quek Shannon , Pionnier Nicolas , Turner Joseph D. , Wanji Samuel , Wagstaff Simon C. , Taylor Mark J.
Published: April 2020

Skin snip evaluation for onchocerciasis has insufficient sensitivity when skin microfilarial (mf) densities are low, such as following ivermectin treatment. Mf density is suitable for assessing microfilaricidal efficacy but only serves as an indirect indicator of macrofilaricidal activity. We assessed circulating nucleic acids from Onchocerca volvulus as an alternative to skin snips. We screened a plasma sample set of infected individuals followed up at four, 12 and 21 months after microfilaricidal (ivermectin, n = four), macrofilaricidal (doxycycline, n = nine), or combination treatment (n = five). Two parasite-derived miRNAs, cel-miR-71-5p and bma-lin-4, and O-150 repeat DNA were assessed. Highly abundant DNA repeat families identified in the O. volvulus genome were also evaluated. miRNAs were detected in two of 72 plasma samples (2.8%) and two of 47 samples (4.3%) with microfilaridermia using RT-qPCR. O-150 DNA was detected in eight (44.4%) baseline samples by qPCR and the number of positives declined post-treatment. One doxycycline-treated individual remained O-150 positive. However, only 11 (23.4%) samples with microfilaridermia were qPCR-positive. Analysis by qPCR showed novel DNA repeat families were comparatively less abundant than the O-150 repeat. Circulating parasite-derived nucleic acids are therefore insufficient as diagnostic tools or as biomarkers of treatment efficacy for O. volvulus.
Tuneable quantum spin Hall states in confined 1T' transition metal dichalcogenides
Authors: Das Biswapriyo , Sen Diptiman , Mahapatra Santanu
Published: April 2020

Investigation of quantum spin Hall states in 1T' phase of the monolayer transition metal dichalcogenides has recently attracted the attention for its potential in nanoelectronic applications. While most of the theoretical findings in this regard deal with infinitely periodic crystal structures, here we employ density functional theory calculations and $$k.p$$
k
.
p
Hamiltonian based continuum model to unveil the bandgap opening in the edge-state spectrum of finite width molybdenum disulphide, molybdenum diselenide, tungsten disulphide and tungsten diselenide. We show that the application of a perpendicular electric field simultaneously modulates the band gaps of bulk and edge-states. We further observe that tungsten diselenide undergoes a semi-metallic intermediate state during the phase transition from topological to normal insulator. The tuneable edge conductance, as obtained from the Landauer-Büttiker formalism, exhibits a monotonous increasing trend with applied electric field for deca-nanometer molybdenum disulphide, whereas the trend is opposite for other cases.
Bio-properties of Saba banana (Musa ‘saba’, ABB Group): Influence of maturity and changes during simulated in vitro gastrointestinal digestion
Authors: Reginio Florencio Collado , Qin Wei , Ketnawa Sunantha , Ogawa Yukiharu
Published: April 2020

Saba banana, a popular fruit crop grown in Southeast Asia, is an economical source of a variety of beneficial agents. This study examined the variations in total phenolic, flavonoid, and antioxidant activities of five maturity stages of Saba banana, and their changes during simulated in vitro gastrointestinal digestion as affected by varying structural compositions. Antioxidant activities were evaluated using ferric reducing antioxidant power (FRAP), metal ion chelating (MIC) activity, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. Results of DPPH and ABTS were compared in terms of TEAC (Trolox Equivalent Antioxidant Capacity) and VCEAC (Vitamin C Equivalent Antioxidant Capacity) values. Bio-properties were found to be highest in mature green stage with values slightly decreased as ripening proceeded. Simulated digestion showed a continuous increase in total phenolic with comparatively faster release in structure-less state (slurry) than samples with intact structure (cut). The trend of antioxidant activities was increased in the gastric phase and then decreased at the onset of intestinal phase, except for MIC which showed a reverse effect. Our study indicated that the bio-properties of Saba banana were affected by maturity and modifications in its physical structure and composition could influence the release behaviors of food components during simulated digestion.