bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role and Characteristics of National Accounting Standard Setters in the European Union: A Comparative Analysis
Authors: Ucieda Blanco José Luis , Santos Cabalgante Beatriz , Romero Fúnez Domi
Published: January 2025

). This poses the question of how these institutions adapt to a changing environment and what factors shape their structure. We provide updated information on 17 National Accounting Standard Setters (NASS) from 15 EU countries plus Australia and USA. The results reveal the four most relevant dimensions of each NASS (nature, organization, financing, and transparency) and identify two main models of NASS (public and private). The paper also discusses potential applications of this data, mainly to examine whether (and how) certain institutional factors could enhance the quality of financial reporting.

El trabajo estudia la persistencia de las instituciones nacionales/locales en un escenario (contabilidad) donde las normas son globales/internacionales (o convergen). Esto plantea la cuestión de cómo estas instituciones, que intervienen en un entorno cambiante, se configuran. Aportamos información actualizada sobre 17 Organismos Nacionales Reguladores de la Contabilidad (15 países de la UE más EE.UU. y Australia). Los resultados muestran las cuatro dimensiones más relevantes de cada organismo (naturaleza, organización, financiación, y trasparencia) y distinguen dos modelos de NASS (público y privado). El trabajo también sugiere diferentes vías para explotar y utilizar académicamente estos datos, principalmente para estudiar si (y cómo) las características de los NASS pueden mejorar la calidad de la información financiera.
Can more able CEOs reduce the gap between internal and external CSR disclosures?
Authors: Kazim Irfan , Wang Fangjun , Nie Dongfang , Jameel Hussain Muhammad
Published: January 2025

This study examines the association between chief executive officer (CEO) ability and the gap between internal and external corporate social responsibility (CSR) disclosure. We find that a firm’s CSR disclosure gap decreases when its CEO's ability increases. We also find that this negative association is strengthened when a CEO has political connections and when a CEO is internally promoted (inside CEO). Our results are robust after controlling for firm fixed effect and addressing endogeneity concerns. Overall our findings are consistent with our argument that more able CEOs significantly reduce the CSR disclosure gap and maintain the positive relationship between internal and external stakeholders. These results carry substantial implications for both theory and practice. From a practical standpoint, our findings emphasize the pivotal role of capable CEOs in orchestrating consistent CSR narratives that resonate internally and externally. This study offers valuable insights for corporate leaders striving to enhance their firms' CSR transparency and maintain favourable stakeholder relationships.

Este estudio examina la relación entre la capacidad del consejero delegado y la brecha entre la divulgación interna y externa de la responsabilidad social corporativa (RSC). Se observa que la brecha de divulgación de la RSE de una empresa disminuye cuando aumenta la capacidad de su consejero delegado. También observamos que esta asociación negativa se refuerza cuando el CEO tiene conexiones políticas y cuando es promovido internamente (inside CEO). Nuestros resultados son robustos tras controlar el efecto fijo de la empresa y abordar los problemas de endogeneidad. En general, nuestros resultados son coherentes con nuestro argumento de que los CEO más capaces reducen significativamente la brecha de divulgación de la RSC y mantienen la relación positiva entre las partes interesadas internas y externas. Estos resultados tienen importantes implicaciones teóricas y prácticas. Desde un punto de vista práctico, nuestras conclusiones subrayan el papel fundamental que desempeñan los directores generales capaces de orquestar narrativas de RSC coherentes que resuenen interna y externamente. Este estudio ofrece valiosas ideas a los directivos de empresas que se esfuerzan por mejorar la transparencia de la RSE de sus empresas y mantener relaciones favorables con las partes interesadas.
How are accounting irregularities examined in Spanish insolvency proceedings? An empirical analysis
Authors: Monterrey Mayoral Juan , Rabazo Martín Aurora-Esther
Published: January 2025

In this paper we have conducted an empirical analysis of the relevant accounting irregularities assessed in Spanish bankruptcy proceedings. Based on a sample of 121 judgments in which the Mercantile Courts and the Provincial Courts analysed the accounting situation of bankrupt companies, we have obtained evidence that judges and courts take into account both quantitative and qualitative factors of the materiality of the infractions, and that judges specialised in mercantile matters tend to apply stricter levels of materiality than non-specialists. However, neither accounting offences nor the degree of specialisation of the judges seemed to have a significant impact on the sentences imposed. Finally, we did not find that implicitly selected materiality levels in precedent judgments could condition or influence the qualification of accounting irregularities in judicial demarcations.

En este trabajo llevamos a cabo un análisis empírico de las irregularidades contables relevantes, que son enjuiciadas en el seno de los procedimientos concursales españoles. Con base en una muestra de 121 sentencias en las que los Juzgados de lo Mercantil y las Audiencias Provinciales analizaron la situación contable de las empresas concursadas, hemos obtenido evidencia de que los jueces y tribunales toman en consideración tanto los factores cuantitativos como cualitativos de la materialidad de las infracciones, y de cómo los jueces especializados en materias mercantiles tienden a mostrar unos niveles de materialidad más estrictos que los no especialistas. No obstante, ni las infracciones contables ni el grado de especialización de los jueces parecen tener influencia significativa en las condenas impuestas. Por último, no hemos apreciado que, en las demarcaciones judiciales, los niveles de materialidad implícitamente seleccionados en las sentencias precedentes pudieran condicionar o influir la calificación de las infracciones contables.
The Role of Blended Learning in Improving Students’ Numerical Ability and Learning Creativity
Authors: Supriadi Nanang , Jamaluddin Z Wan , Suherman Suherman , Komarudin Komarudin
Published: January 2025

Research exploring the potential benefits of blended learning in enhancing numeracy and creativity is imperative. This study aims to evaluate the impacts of the blended learning approach on both numerical proficiency and creative learning of students. Using the quasi-experimental model, the investigation involved 60 secondary students during the spring semester, divided into experimental and control groups. Data collection used questionnaires and tests, with analysis performed using SPSS 29 and Winstep software. The findings reveal a significant influence of the blended learning model on numerical ability, even when considering the creative learning of the students. Additionally, creative learning by students significantly affects numerical ability. These results underscore the importance of implementing blended learning in high schools, as it fosters the development of both numerical skills and creativity.

La investigación sobre los posibles beneficios del aprendizaje mixto en la mejora de la capacidad numérica y la creatividad es imprescindible. Este estudio tiene como objetivo evaluar los impactos del enfoque de aprendizaje mixto en la competencia numérica y el aprendizaje creativo de los estudiantes. Utilizando el modelo cuasi-experimental, la investigación involucró a 60 estudiantes de secundaria durante el semestre de primavera, divididos en grupos experimentales y de control. La recolección de datos se realizó mediante cuestionarios y pruebas, con un análisis realizado utilizando el software SPSS 29 y Winstep. Los hallazgos revelan una influencia significativa del modelo de aprendizaje mixto en la habilidad numérica, incluso considerando el aprendizaje creativo de los estudiantes. Además, el aprendizaje creativo por parte de los estudiantes afecta significativamente la habilidad numérica. Estos resultados subrayan la importancia de implementar el aprendizaje mixto en las escuelas secundarias, ya que fomenta el desarrollo tanto de habilidades numéricas como de creatividad.
Ground glass opacity detection convolutional neural network method efficient net-b0 architecture in corona virus disease 2019 cases
Authors: Dwi Ajeng Risqy Hasanah Syam  , Donny Kristanto Mulyantoro  , Siti Masrochah  , Nurul Auliyaa Hasbi  , Indah Musdalifah  , Sitti Normawati
Published: January 2025

COVID-19 is an infectious disease caused by a new type of coronavirus. The gold standard diagnosis of COVID-19 is a PCR test. Thorax radiographic examination is an alternative to the diagnosis of COVID-19 against initial screening. Thorax radiography sensitivity is lacking in GGO detection of COVID-19. CNN's deep learning architecture EficientNet-B0 has the ability to represent the same diagnostic prediction features as radiologists. The purpose of this study resulted in CNN's EfficientNet-B0 architecture that is able to classify radiographic images of the thorax automatically in detecting GGO COVID- 19 and has similar results with the results of the doctor's experiment. This type of research is a quasi-experimental design Post-test Only Control Group Design. Build the CNN EfficientNet-B0 architecture through the MATLAB R2021a program. The sample totaled 78 radiographic images of the thorax. The data analysis is a statistical test of Chi-Square. Research proves CNN's performance of the EfficientNet-B0 architecture is excellent in detecting GGO COVID-19 with an AUC value of 0.994 range (0.90-1.00). The deep learning model can be considered as an alternative tool for establishing a diagnosis of COVID-19 with the condition that the verification of the diagnosis decision remains based on the confirmation and justification of the radiologist.
Constitutional Homoeopathic approach - In the case of Lichen Planus
Authors: Jaspinder Kaur
Published: January 2025

Background: Lichen planus (LP) is a provocative skin problem, described by a bothersome, sparkling, violaceous, level-bested, papular emission over various pieces of the body. Since the regular method of medication doesn't fix the sore but smothers it, in the equivalent or the other structure. Homoeopathy running against the norm plays a critical part in the treatment of LP based on the entirety of side effects (individualization) and comprehensive methodology. In the event of LP, Homeopathic meds focus on the changed resistance of the body and take it back to typically over the timeframe. An instance of an LP of 48 years of a male is introduced in this article who answered praising with single medication Arsenicum album relying upon the entirety of side effects repertorial result. A decrease in the size and number of emissions was seen over a time of Multiple months.
 An itemized case-taking was finished and LP was analyzed on the premise of clinical history, actual assessment, and biopsy report. Individualized Homeopathic medication was given based on the entirety of the side effects.
The patient recuperated surprisingly with Homeopathic treatment.
Conclusion: Homeopathy has treated a hard-to-treat condition, for example, LP, in somewhat less time, where moderate treatment neglects to give positive outcomes.
Exploring Novel Cancer Targets Unveiled By Established Nsaids
Authors: Ramsiya K  , Digi Davis C  , Neeshma K  , Razana Binth Yoosuf P  , Rahila  , Rubayyath K  , Shafnaz Abdul Rahman
Published: January 2025

Nonsteroidal anti-inflammatory drugs (NSAIDs), particularly selective inhibitors of cyclooxygenase-2 (COX-2), have emerged as promising candidates for their potential to combat cancer. Epidemiological, clinical, and preclinical investigations have consistently demonstrated their association with a reduced incidence of various cancers, including colorectal, lung, esophageal, pancreatic, cervical, skin, and ovarian cancers. However, the clinical application of traditional NSAIDs is hindered by gastrointestinal adverse effects. Selective COX-2 inhibitors offer improved gastrointestinal profiles, sparking interest in their role as chemopreventive agents. Yet, uncertainties persist regarding whether the anticancer effects of NSAIDs solely stem from COX inhibition or involve COX-independent mechanisms.
This review aims to delineate the anticancer mechanisms of NSAIDs, focusing on aspirin and similar agents, while exploring avenues for enhancement. Mechanistic insights suggest potential targets beyond COX enzymes, such as phosphodiesterase-5 (PDE5) inhibition, leading to apoptosis induction. Additionally, advancements in medicinal chemistry propose novel strategies, including aspirin prodrugs, nitroaspirin, NF-κB inhibitors, and modified sulindac derivatives, for targeted cancer therapy. Furthermore, 2-arylpropionic acid-derived NSAIDs have demonstrated antiproliferative effects across various cancer cell lines, highlighting their potential as lead compounds for potent and safe anticancer agents.
Despite these advancements, further research is warranted to elucidate precise mechanisms of action, optimize treatment regimens, and evaluate risk-benefit ratios. By advancing our understanding of NSAIDs in cancer prevention and treatment, we can potentially revolutionize cancer care paradigms.
Dental Tourism as a Health Tourism Business Opportunity in Bali
Authors: Dwiastuti Sagung Agung Putri , Ratih Ida Ayu Dewi Kumala
Published: January 2025

Dental tourism is a branch of medical tourism, if developed it can generate income for the state, outside of direct income from dental clinics. The aim of this research is to find out efforts to develop dental tourism in Bali in 2023.
The research includes qualitative and qualitative research with descriptive data. The population of all dental clinics that serve domestic and foreign dental tourists who receive dental treatment in Bali while on tour and clinics that serve tourists who receive dental treatment in Bali.  Samples were taken accidentally, namely clinics in Bali that provide dental care services in Bali. The data obtained will be analyzed using descriptive statistics calculated using SPSS Version 20 and qualitative analysis.
The results of the research are that the practice of Dental Tourism already exists in Bali, the services provided by clinics and dental services in Bali (practice facilities, human resources, prices, materials) are good, and this is acknowledged by customers, only promotions are less than optimal and legal aspects are not yet available. because of existing regulations. So, the suggestion is that the Ministry of Health can revise PMK No. 76 of 2015 so that the criteria for hospitals that can serve are from type B to C. Dentists who practice dental tourism should enter the BMTA. Establishment of an activity model for dental tourism patients who can travel to Bali.
Design And Development Of Curcumin Loaded Nanorobots For Targeting Colon Cancer
Authors: Ubaidulla Uthumansha  , Mohamed Asrarullah M.H  , Mohammad Samiyullah. S
Published: January 2025

Colorectal cancer is one of the most widespread tumors worldwide, and it is considered to be the second leading cause of death among cancer groups. Natural compounds, such as curcumin, have shown significant anti-colorectal cancer characteristics among medications that can be used to treat colorectal cancer. Targeted drug delivery systems are essential for improving the effectiveness of cancer treatment while minimizing side effects. The development of smart curcumin nanorobots for targeting colon cancer cells is a significant advancement in this field. By utilizing green synthesis of magnetite, coating curcumin nanoparticles, and incorporating them into smart nanolegs, a motile and targeted drug delivery system has been successfully created.
Development and validation of rp-hplc method for simultaneous estimation of imeglimin and metformin used for The treatment of diabetes
Authors: Adimulam Sailaja  , Gorantla Nagamallika
Published: January 2025

A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Imeglimin And Metformin, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Hypersil C18 (4.6×250mm) 5µ column using a mixture of Water and Acetonitrile (50:50) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 244nm. The retention time of the Imeglimin and Metformin was 2.0, 4.0±0.02min respectively. The method produce linear responses in the concentration range of 20-100µg/ml of Imeglimin and 40-200µg/ml of Metformin. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.
Formulation And Evaluation Of Indomethacin Liposomes
Authors: Ayesha Anjum  , Gorantla Nagamallika
Published: January 2025

Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation. The objective of the present study was to formulate and evaluate liposomes loaded with Indomethacin. Liposome of Indomethacin was made by thin film hydration method. Phospholipids and cholesterol were used to make multilamellar vesicles. Six batches of liposomes were prepared based on the different weight ratio of Phospholipids and cholesterol. Differential scanning calorimetry (DSC) study conducted to study in any incompatibility. Liposomes were produced by the thin-film hydration method. Six formulations of liposomes were prepared by varying the concentrations of Phospholipids and cholesterol and changing the drug ratio. The obtained liposomes were characterized for surface morphology, FTIR, particle size, zeta potential, drug content, entrapment efficiency, and in-vitro diffusion studies. Among the Six formulations of liposomes, F5 was found to be the best formulation with entrapment efficiency of 85.81% and a zeta potential value of -28.4mV. Liposomes followed Peppas release kinetics. Indomethacin loaded liposomes were prepared with good stability and the highest entrapment efficiency
Knowledge of human milk banking among nurses in selected institution in Bangalore, 2024
Authors: Archana. B
Published: January 2025

Introduction
Human milk banks play a crucial role in providing new-borns with pasteurized and donor human milk, thereby enhancing the benefits for both mothers and babies. Human milk banks provide pasteurized breast milk to neonates who cannot receive it from their biological mothers, promoting optimal nutrition and health for vulnerable neonates, especially those with special medical conditions.
Objective
To assess knowledge of Human milk banking among nurses in selected institution in Bangalore, 2024.
Methodology
The institution-based cross-sectional study design was conducted among 204 nurses. Samples were selected by purposive sampling technique. Data were collected using a structured knowledge questionnaire in June 2024.
Results
A total of 204 participants were employed in this study. Out of 204 total participants, 105 (51.47%) were female. The majority 98 (48.03%) of the participants belong to the Age group of 31 and above. About 134 (65.68%) were undergraduate and forty-six (22.54%) had postgraduate degrees. Among the participants 139 (68.13%) were single. Mainstream 110 (53.92%) belonged to rural residents and most of the 124 (60.78%) came from single families. One hundred forty-one (69.11%) had 1-5 years of work experience. About 91 (44.60%) had no awareness and about 104 (50.98%) study members had good knowledge about human milk banking.
Conclusion
The present study concluded only half of the participants had good knowledge about human milk banking. Additional studies have to be conducted with a multicentre approach with quantitative design and allied factors.
To study scapular position in Architecture students with non-specific neck pain – A cross-sectional study
Authors: Shrutika Shashikant Fulare  , Snehalata Tembhurne  , Snehal Ghodey3
Published: January 2025

Background: Architecture students attain static slouched posture during their drawing and drafting work. Also, the furniture provided by college / Universities does not fit every student’s stature. Imbalanced force production of upper and lower trapezius muscle and serratus anterior give rise to abnormal scapulohumeral rhythm. But there is a lack of evidence to explain the relation between scapular position and non-specific neck pain in architecture students.
Objectives: To study scapular position using Lennie’s test in Architecture students with non-specific neck pain. To study scapular position using Kibler’s method of Lateral scapular slide test in Architecture students with non-specific neck pain.
Method: A cross-sectional study was conducted among 50 Architecture students with nonspecific neck pain. For examination of scapular position Lennie’s test and Kibler’s lateral scapular slide tests were performed. Kibler’s tests were performed in three different positions (at rest, hands on hip, and shoulder with 90o abduction and internal rotation). With marker scapular surface landmarks and spinal midline were marked. Bilateral measurements were taken using digital Vernier calliper.
Result: Result shows that there is significant alteration of scapular position in architecture students with non-specific neck pain. In Lennie’s test, superior angle of scapula was altered in 98%, root of spine of scapula was altered in 94% and inferior angle of scapula was altered in 96% of population with chi square value of 0.56 and p-value 0.7558.
Conclusion: The present study concluded that there is an association between non-specific neck pain and altered scapular position in Architecture students.
Evaluating the neonatal formulation of famotidine in a live setting
Authors: Golla Anjali Yadav  , Jhancy Laxmi bai  , V. Algarswamy
Published: January 2025

Oral controlled release (CR) dosage forms (DFs) have been developed over the past three decades due to their considerable therapeutic advantages such as ease of administration, patient compliance and flexibility in formulation. However, this approach is bedilled with several physiological difficulties such as inability to restrain and locate the controlled drug delivery system within the desired region of the gastrointestinal tract (GIT) due to variable gastric emptying and motility. Furthermore, the relatively brief gastric emptying time (GET) in humans which normally averages 2-3 through the major absorption zone, i.e., stomach and upper part of the intestine can result in incomplete drug release from the drug delivery system leading to reduced efficacy of the administered dose. Therefore, control of placement of a drug delivery system (DDS) in a specific region of the GI tract offers advantages for a variety of important drugs characterized by a narrow absorption window in the GIT or drugs with a stability problem.These considerations have led to the development of a unique oral controlled release dosage form with gastro retentive properties. After oral administration, such a DF would be retained in the stomach and release the drug there in a controlled and prolonged manner, the drug could be supplied continuously to its absorptions in the upper gastrointestinal tract. Gastro retentive dosage form can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of drugs. Prolonged gastric retention improves bioavailability, reduces drug waste, and improves solubility of drugs that are less soluble in a high pH environment. It is also suitable for local drug delivery to the stomach and proximal small intestine.
Experimental design approach by using rhplc for the determination of rufinamide assay in dose proportional tablet Rufinamide tablets 200 mg
Authors: L. Saikiran Goud  , K. Vamshi Krishna  , Mohammad Omar
Published: January 2025

A rapid high performance liquid dosage form. A Kromasil C118, 125 X 4.0 mm, 5µm or or equivalent in isocratic mode, with mobile phase containing a mixture of Weight and transfer about 2.72 of Potassium Di hydrogen phosphate  into a beaker containing 1000ml of water,  and filter through 0.45µ nylon membrane filter, mobile phase Thoroughly mix buffer, methanol and tetrahydrofuran in the ratio of 80: 15:05 % v/v and Prepare a degasses mixture of water, methanol and acetonitrile  in the ratio of 10:50:40 % v/v, The mobile phase was pumped at a flow rate of 1.0 ml/min and the eluents were monitored at 210 nm. The selected chromatographic conditions were found to effectively separator (Rt: 8.98 min) having a resolution of 5.87. The method was validated in terms of linearity, accuracy, precision, specificity, limit of detection and limit of quantitation. Linearity for were found okay respectively. The percentage recoveries for ranged from 99.97-100.0%, respectively. The limit of detection and the limit of quantitation for was found to be 1.5 μg/ml and 3.0 μg/ml, respectively. The method was found to be robust and can be successfully used to determine the drug content of marketed formulations. The method gives resolution with a short analysis time (< 30 min). The method parameter was validated and establish to be simple, sensitive, accurate and precise. Percentage of recovery shows that the method is free from interference of the excipients used in the formulation. Therefore, the planned method can be used for routine analysis of in medical dosage form.
Design of Experimental approach for the quantification of Bictegravir, content by dissolution method in Tablets formulation using RP-HPLC method
Authors: Budda Ruthu Salomi  , A. Shailaja  , Mohammed Omar
Published: January 2025

In the current study the effort has been undertaken to improve most simple, economical, and sensitive and correct analytical HPLC method for the immediate valuation of these drugs without their prior separation. The method gives resolution with a short analysis time (< 25 min). The method parameter was validated and establishes to be simple, sensitive, accurate and precise. Percentage of recovery shows that the method is free from interference of the excipients used in the formulation. All the three ingredients were effectively resolved and quantified. The developed method reported herein was validated by parameters agreeing to ICH-Q2B guidelines. The offered method provided good system suitability, resolution, precision, accuracy, LOD and LOQ, linearity and robustness and requires less expensive reagents. The procedure designated now is simple, rapid, sensitive, selective and cost effective. It is apparent from the results that the suggested procedure is well suited for dissolution and assay and evaluation of drug, in dosage forms
Evaluating the neonatal formulation of famotidine in a live setting
Authors: Golla Anjali Yadav  , Jhancy Laxmi bai  , V. Algarswamy
Published: January 2025

Evaluating the Neonatal Formulation of Famotidine in a Live Setting Dosage forms that can be retained in the stomach are called gastro retentive drug delivery system(GRDDS).GRDDS can improve the controlled delivery of drugs that have an absorption window by continuously releasing the drug for a prolonged period of time before it reaches its absorption site.
Oral controlled release (CR) dosage forms (DFs) have been developed over the past three decades due to their considerable therapeutic advantages such as ease of        administration, patient compliance and flexibility in formulation. However, this approach is be dilled with several physiological difficulties such as inability to restrain and locate the controlled drug delivery system within the desired region of the gastrointestinal tract (GIT) due to variable gastric emptying and motility.
Gastro retention helps to provide better availability of new products with suitable therapeutic activity and substantial benefits for patients. This mode of administration would best achieve the known pharmacokinetic and pharmacodynamic advantages of CR-DFs of these drugs.
Formulation And In Vitro Evaluation Of Dalfampridine Sustained Release Tablets By Using Various Polymers
Authors: P. Jyothishna  , A. Madhusudhan Reddy
Published: January 2025

In present investigation the sustained release tablets of Dalfampridine was formulated to study effect various natural polymers of Tragacanth, Acacia gum and Xanthan gum. The model is based on a novel dosage form designed to deliver a drug into the gastrointestinal tract in a controlled manner. Matrix tablets were prepared by direct compression method. As a pre-requisite and part of pre-formulation studies, drug along with selected excipients and as optimized formulation was subjected to FT-IR studies. It was found that no interaction among excipients occurred, as no extra peaks obtained. Tablets were evaluated for various IP-QC tests like hardness, friability, content uniformity and in-vitro drug release by USP paddle apparatus. It was found that the release of drug D3 formulation showed 99.83% the formulation was gave the better release than other formulations. In these nine formulations D3 formulation was showing highest release following Peppas release kinetics.
Role Of Copp In Pharmaceutical Export
Authors: R. Dileep  , B. Thejovathi
Published: January 2025

This review includes basics of CoPP, origin of CoPP, types, types of drug includes in CoPP, procedure to obtain CoPP, requirement for CoPP, applicant, examples, format and content and benefits of CoPP. A CoPP is given by the drug regulator not before conducting an inspection of the manufacturing plant. Proper documentation is essential in almost every aspect of the pharmaceutical industry. Whether for product registration, factory inspection, or internal quality control, Adva Care employs the latest technologies to streamline and process information. All facilities possess up-to-date Good Manufacturing Practice (GMP), CE, TUV, and/or ISO certificates that reflect high quality standards and WHO rules and regulations. Essential product registration documents, such as the Certificate of Pharmaceutical Product (COPP), Free Sales Certificate (FSC), Certificate of Origin (COO), and Marketing Authorizations are among the many documents our registration department frequently submit for registration purposes.
Comparative Study Of New Drug Application Procedure In Us, Eu And India
Authors: B. Shivasai  , Shaik Zareena Begum  , S. Sunayana
Published: January 2025

Developing a new drug requires great amount of research work in chemistry, manufacturing, controls, preclinical science and clinical trials. Drug reviewers in regulatory agencies around the world bear the responsibility of evaluating whether the research data support the safety, effectiveness and quality control of a new drug product to serve the public health. Every country has its own regulatory authority, which is responsible to enforce the rules and regulations and issue the guidelines to regulate the marketing of the drugs. This article focuses on drug approval process in different countries like USA, Europe and India.
El Desplazamiento Laboral por la IA: frente al principio de desarrollo y formación profesional.
Authors: Pérez-  Martinez Alejandra , Barrionuevo-  Núñez José Luis
Published: January 2025

El artículo examina la integración de la Inteligencia Artificial (IA) en el ámbito laboral ecuatoriano y su impacto en los derechos de los trabajadores, subrayando la necesidad de un marco normativo robusto que regule el uso de la IA para prevenir el desplazamiento laboral y proteger a los empleados. El objetivo de la investigación es analizar cómo la ausencia de legislación específica en Ecuador, que obligue a los empleadores a capacitar a sus trabajadores en nuevas tecnologías, pone en riesgo la estabilidad laboral en la era digital. La metodología incluye un análisis comparativo entre la normativa europea sobre la IA y la situación legislativa en Ecuador. Se revisan tanto las leyes vigentes como las propuestas normativas internacionales, con especial atención a las medidas de la Unión Europea para limitar el uso de la IA en entornos laborales. Los resultados indican que, mientras la Unión Europea ha implementado leyes para proteger a los trabajadores frente a la automatización, Ecuador carece de un marco legal equivalente. El estudio concluye que Ecuador podría beneficiarse de adoptar normativas similares, que fomenten la capacitación profesional continua y establezcan límites claros al uso de la IA en el trabajo, asegurando que la tecnología complemente, en lugar de sustituir, a la mano de obra humana.
Desafíos jurídicos en el proceso investigativo previo a la acción de repetición en el Ecuador.
Authors: Carrera-  García Verónica Fernanda , Ayala-  Endara Oscar Alberto , Rodríguez-  García Pavlov Neruda
Published: January 2025

Este artículo aborda los desafíos jurídicos en el proceso investigativo previo a la acción de repetición en Ecuador, destacando las dificultades como la falta de coordinación interinstitucional y la carencia de recursos técnicos y humanos. El objetivo fue analizar los desafíos jurídicos que enfrenta el proceso investigativo previo a la acción de repetición en Ecuador, identificando las principales dificultades y proponiendo posibles soluciones para mejorar su eficacia. La investigación se clasifica como un estudio cualitativo, descriptivo y exploratorio, centrado en el análisis de la normativa legal y procedimientos relacionados con la acción de repetición. El enfoque fue doctrinal y jurisprudencial, utilizando métodos teóricos y empíricos. Los resultados alcanzados revelan que, en el Ecuador, a pesar de contar con una base normativa que regula esta figura, se evidencia la necesidad de fortalecer la normativa y los procedimientos para garantizar investigaciones previas efectivas y la adecuada aplicación de la acción de repetición.
La presunción de veracidad de los informes técnicos y la admisibilidad de las pruebas en los procedimientos administrativos sancionadores de salud en Ecuador.
Authors: Molina-  Ramón José Arturo , Batista-  Hernández Noel
Published: January 2025

El estudio analiza críticamente la presunción de veracidad en los procedimientos administrativos sancionadores de salud en Ecuador, evaluando su impacto en la admisibilidad y valoración de pruebas, así como en el derecho a la defensa de los administrados. Desde un marco teórico que conjuga el derecho administrativo con las nociones de justicia procedimental y debido proceso, el estudio expone cómo este principio jurídico, orientado a la simplificación administrativa, tiende a consolidar un desequilibrio en la relación de poder entre la administración y los administrados. La investigación adopta un enfoque mixto con un diseño no experimental, descriptivo, explicativo y propositivo. Se combinan técnicas de análisis documental de normativa vigente, análisis de casos específicos y entrevistas a expertos en derecho administrativo y funcionarios de la Agencia de Aseguramiento de la Calidad de los Servicios de Salud y Medicina Prepagada (ACESS). Los hallazgos revelan que la presunción de veracidad, lejos de garantizar la eficiencia administrativa, tiende a limitar la equidad procesal y la predictibilidad de los resultados, sugiriendo la necesidad de reformas normativas que reequilibren la carga probatoria y fortalezcan el derecho a la defensa.
Aborto y derechos constitucionales en Ecuador: implicaciones de la sentencia no 34-19 in/21.
Authors: Ronquillo-  Numerable Carlos Antonio
Published: January 2025

Este estudio tuvo como objetivo analizar las repercusiones de la Sentencia N° 34-19 IN/21, que despenaliza parcialmente el aborto en casos de violación en el marco jurídico y social del país. A través de una investigación documental bajo un enfoque cualitativo, se examinan la normativa constitucional, la jurisprudencia pertinente y los obstáculos para la implementación efectiva de la sentencia. Los resultados evidencian que este recurso jurisprudencial representa un avance significativo en los derechos sexuales y reproductivos de las mujeres; sin embargo, se siguen presentando limitaciones relacionados a la falta de recursos en el sistema de salud y la resistencia cultural, que dificultan la plena implementación de los derechos reconocidos por la sentencia. En conclusión, para que la sentencia tenga un impacto real, es fundamental que el Estado, el sistema de salud y la sociedad civil trabajen juntos para garantizar el acceso seguro y efectivo a los servicios de aborto, asegurando así la protección de los derechos reconocidos.
Szülői támogatás és hitre nevelés.
Authors: Karainé Gombocz Orsolya
Published: January 2025

Korábbi kutatásaink során több alkalommal is vizsgáltuk a család támaszszerepét. Legutóbbi e témában született közleményünk a családi támogatást általánosságban vizsgálta. Célunk egy átfogó kép megalkotása volt: a család mely szereplői jelennek meg hangsúlyosan a hallgatók támogatásában, és mely területeken érezhető át különösen ez a támogatás. Szembetűnő tapasztalata volt munkánknak, hogy a család világképet és életfilozófiát ad támogató funkció expressis verbis viszonylag kevés válaszadónál jelent meg, és a család az identitás forrása támogató funkció is inkább csak rejtett formában volt tetten érhető a válaszokban. Fontosnak tartottuk, hogy kutatásunkat folytassuk, gondolatmenetünket továbbvigyük ebben a katolikus egyetem tanárképzése szempontjából fontos témában. Tanulmányunk arra tesz kísérletet, hogy a Pázmány Péter Katolikus Egyetem elsőéves bölcsész tanár szakos hallgatói tapasztalatát bemutassa: eddigi életében miként élte meg a fiatal tanárjelölt a családi támogatást a vallás gyakorlásában. Célunk, hogy lehetőségeinkhez mérten feltárjuk, milyen családi támogatásban részesültek ezen a téren hallgatóink, és számba vegyük, mit tehet az egyetem: milyen lehetőségeket kínálhat a vallás gyakorlásában, a hitben való elmélyülésben, és miért fontos ez a katolikus tanárképzésben.
A nevelés hazája
Authors: Kozma Gábor
Published: January 2025

A „nevelés hazája” megközelítés újat hozhat a neveléstudomány és a pedagógiai gyakorlat számára a professziónak az ezredfordulón történt tárgyalása után. Azóta a széteső európai kultúrában mindinkább a nevelésre hárul a hazát, sőt a világot megőrző és a társadalmat éltető szerep. Ez statútuma is a „nevelés hazájának”, aminek mai térképén jutunk el a fejlesztési utak csomópontjaiban működő központok szerepének tárgyalásához. Az új kihívásokhoz igazodó hivatástradíciók hiányában a sürgősségi megoldások a nevelés mind fájdalmasabb sebeinek csak a tetejét kezelik. A „nevelés hazájában” gyakran korábban születnek meg az újgenerációs hivatásképzések, mint hogy rendeződhetnének rokoni kapcsolataik a neveléstudomány és a pedagógia viszonyaival. A 20. századra intézményesült óvó és tanító hivatások, majd pedig a bölcsész paradigmából kaput nyitó tanárképzés melletti kibontakozásuk jellemzője a multidiszciplinaritás, amely az „embertudományok” modern kori felgyorsult fejlődéséből merítkezik. A bölcsész paradigma alapkérdése az elmélet és a gyakorlat közti viszonynak a hatékonyságot célzó versengése. Mindez a tudás adaptivitásának szerepére irányítja a figyelmet. Az adaptivitás és a normativitás kereszteződéseinek azonosításához a 20. század első felére való újbóli rátekintés is fontos. A „nevelés hazája” térképén eljutunk Esztergomba, ahol a pedagógusképzési utak jelenét is tárgyalhatjuk.
A füzetmunka szerepe a Waldorf-iskola első nyolc évében
Authors: Pajorné Kugelbauer Ida
Published: January 2025

A Waldorf-pedagógia epochális oktatásának sajátossága, hogy epochafüzetet készítenek a gyerekek, amely a tankönyvük is egyben. A rajzolással kísért füzetmunkának a tanítás-tanulás folyamatában a tananyag rögzítése, elmélyítése és művészi átélésével a belsővé válás a célja. Tanulmányomban egy Waldorf-iskolai osztály nyolc év alatt készült füzetmunkáit mutatom be és elemzem kiemelten a vizuális nevelés szempontjából. Waldorf-osztálytanítóként 2015-től 2023-ig a Váci Waldorf Általános Iskolában tanítottam. A nyolc év alatt az osztályomban a gyerekek által készített füzetekről (írás, olvasás, számolás, irodalom, nyelvtan, történelem, matematika, geometria, biológia, kémia, fizika, földrajz) fotódokumentációt készítettem. A gyerekek alkotásainak elemzésével szeretném bemutatni, hogy milyen lehetőségek rejlenek abban, ha a rajzolást a tanulás eszközének tekintjük, és beépítjük a tanítás-tanulás folyamatába. A longitudinális vizsgálat lehetőséget nyújt az életkor előrehaladásával a tanítás-tanulás módszertan változásainak bemutatására. A füzetekben a gyerekek életkorának növekedésével a rajzi képességeik fejlődnek, a vizuális kommunikáció területei egyre bővülnek. A kifejező alkotások, tanulmányrajzok, térképek, magyarázórajzok, díszítőmotívumok és szövegek alkotnak egységet, a tanulás szolgálatában.
A környezeti nevelés ismeretköreinek megjelenése az alsó tagozatos oktatásban
Authors: D. Tóth Márta , Csizmadia Ildikó
Published: January 2025

A gyermekek környezettudatos szemléletének formálása már óvodáskorban megkezdődik, majd az általános iskolai nevelés ad lehetőséget arra, hogy a diákok megismerjék a környezeti problémákat, az ehhez kapcsolódó antropogén hatásokat. Az iskolai oktatómunka segíti a környezetvédelemért felelős gondolkodás kialakítását is, az iskolai környezetben számos tevékenység lehetőséget biztosíthat erre tanórán vagy tanórán kívül. Jelen tanulmányban azt vizsgáljuk, hogy első, második, harmadik és negyedik osztályban a környezetismeret tantárgyon kívül más tantárgyakban is oktatják-e a pedagógusok a környezetvédelmi témákat, ezek színterei hol vannak, és milyen óraszámban jelennek meg. A felmérés kérdőíves módszerrel történt, Szabolcs-Szatmár-Bereg vármegyében és Hajdú-Bihar vármegyében található 10 iskolában tanító pedagógusok körében. Eredményeink azt mutatják, hogy a megkérdezett pedagógusok által tanított tantárgyakban a környezetismeret tantárgyon kívül is megjelennek a környezetvédelmi ismeretkörök, mind a négy évfolyamon, leginkább a magyar nyelv és irodalom, a technika és életvitel és a vizuális kultúra tantárgyakban. Tantermi tanórán nagyobb óraszámban alkalmazzák a környezetvédelmi témákat az általunk megkérdezett pedagógusok, mint tantermi órán kívül. A tantermi órán kívül legnagyobb óraszámban az erdei iskolában foglalkoznak a megkérdezettek a vizsgált környezetvédelmi témákkal.
A Nyíregyházi Állami Elemi Népiskolai Tanítóképző tanulóinak több szempontú vizsgálata 1914–1961 között
Authors: Dráviczki Sándor
Published: January 2025

A tanulmányban a Nyíregyházi Állami Elemi Népiskolai Tanítóképző személyi tényezőit (tanulók) szeretném vizsgálat alá vonni 1914 és 1961 között. A tanulmány elején a tanítóképző kialakulását, a tanítóképzésben bekövetkezett szervezeti változásokat vizsgálom. Ezt követően a tanulók elemzését tárom az olvasó elé. A tanulók vizsgálatánál a beiratkozott, képesítést szerzettek számát mutatom be. A különböző időszakokban a minisztérium az osztályonkénti tanulók számát próbálta befolyásolni a túlképzés miatt. Az intézet ezzel kapcsolatos fellépését tárom fel. Elemzem a lemorzsolódás mértékét, nagyságát. A tanulmányban próbálom feltárni a lemorzsolódás okait, illetve a tanárok küzdelmét a lemorzsolódás ellen. Ezt követően a tanulók vallási megoszlását elemzem 1914 és 1948 között. A tanulmányban kitérek a tanulók szociális származására, vizsgálva a szülők foglalkozás szerinti megoszlását. Az 1914 és 1948 közötti időszakban megvizsgálom az iskola székhelyének szülőtársadalmát, feltérképezem a befolyásos szülőcsoportok körvonalait. Majd ezt követően a tanulók lakóhely szerinti megoszlását, a képző beiskolázási területét mutatom be. Kitérek az anyanyelv szerinti megoszlásra, a tanulók előtanulmányára. A dolgozat végén a tanulók felvételi eljárását vizsgálom az intézetben.
‘To do or not to do’
Authors: Fendel Victoria Beatrix
Published: January 2025

The support verbs ποιέομαι poieomai ‘to do’ and τίθημι tithēmi ‘to put’ exist in bound and unbound forms from classical into medieval times, ποιέομαι poieomai as ποιέομαι poieomai and -ποιέομαι -poieomai, τίθημι tithēmi as τίθημι tithēmi and -θετέω -theteō. They differ from auxiliaries, in that they are semi-lexical as they contribute to the event structure of the verb phrase. The article draws on the literary corpus of the Thesaurus Linguae Graecae and the documentary corpus of the Duke Database of Documentary Papyri to answer three research questions: (i) Are support verbs the unbound alternative of bound affixes? (ii) How do semi-lexical support verbs become semi-grammatical affixes? (iii) Why did -ποιέομαι -poieomai ‘to do’ and -θετέω - theteō ‘to put’ not become productive? It finds that the bound and unbound forms of the support verb differ in the semantics of the lexical unit and its pragmatic embedding. Through the univerbation of leader words and their subsequent reanalysis, a new word-formation pattern emerges, which never becomes productive but is available as a creative option especially in technical registers (akin to English readable alongside established legible) from the Ptolemaic/Roman periods onwards. This new word-formation pattern involves a semi-lexical affix, just like the unbound support verb.
Corrigendum
Authors: Cai Yida
Published: January 2025

The author information in the book review “Dalrymple, Mary & Lowe, John J. & Mycock, Louise (eds.). 2019. The Oxford Reference Guide to Lexical Functional Grammar. Oxford: Oxford University Press. Pp. 835” published in the issue Vol. 35 (2022) of the Finnish Journal of Linguistics was incorrect, the correct information is “Dalrymple, Mary & Lowe, John J. & Mycock, Louise. 2019. The Oxford Reference Guide to Lexical Functional Grammar. Oxford: Oxford University Press. Pp. 835”. Consequently, the first sentence of the book review is “The Oxford reference guide to Lexical Functional Grammar is a volume offering wide-ranging and detailed information about Lexical Functional Grammar (LFG).”
Alfabetización climática en la formación inicial docente
Authors: Flores Raúl Calixto , Reyes Martínez Daniela
Published: January 2025

Ensayo que aborda de forma reflexiva el cambio climático en las escuelas como un reto complejo debido a la naturaleza global y multifacética de este fenómeno. Se estima que simplificar este problema puede llevar a soluciones incompletas o inadecuadas. Es fundamental que los estudiantes comprendan que el cambio climático trasciende fronteras y afecta a todo el planeta. Además se explica que en la formación docente, resulta esencial profundizar en las causas del cambio climático, vinculadas a nuestros estilos de vida, y explorar estrategias prácticas para mitigar sus efectos a nivel local. Al promover un pensamiento crítico y una comprensión integral del problema, podemos empoderar a los futuros docentes para que guíen a sus estudiantes hacia una ciudadanía más consciente y comprometida con la sostenibilidad ambiental.
La Educación Científica en Niños y Niñas sobre la Forma de la Tierra
Authors: Llanos Baldivies Javier Rodrigo , Céspedes Calatayud María Elena
Published: January 2025

La educación infantil es un área muy importante a estudiar dentro del campo de la pedagogía, es primordial tomar en cuenta diversos aspectos socioculturales, particulares y personales para aplicar la mejor estrategia para lograr cimentar adecuadamente conocimientos científicos en niños en la primera infancia. Hoy en día se plantea el uso de la llamada pedagogía científica, la cual aplica el método científico a través de experiencias vivenciales, experimentos, recursos audiovisuales y uso de tecnología; aparte del buen uso de recursos, se plantea enfocar el proceso educativo en fomentar la curiosidad intelectual innata del estudiante y su ímpetu por descubrir nuevas cosas, para involucrarlo de manera activa en la búsqueda de nuevos conocimientos. Sumado a todo esto, la importancia de la adecuada preparación del docente, a fin de que pueda satisfacer de manera óptima las dudas de los estudiantes durante las clases, con dominio absoluto del tema. La evidencia sustenta que, con la aplicación de estos recursos, el proceso de aprendizaje de los niños puede optimizarse logrando resultados satisfactorios con mayores facilidades y mejores resultados que con la pedagogía tradicional.