bluuebunny/crossref_metadata_2025 huggingface dataset:
Hemodynamic evaluation of coronary artery bypass graft lesions using fractional flow reserve
Authors: Aqel Raed , Zoghbi Gilbert J. , Hage Fadi , Dell'Italia Louis , Iskandrian Ami E.
Published: July 2008

Background:

Coronary angiography is limited by its inability to assess the hemodynamic significance of a coronary artery stenosis. The assessment of the physiological significance of saphenous vein graft (SVG) lesions with a pressure wire to determine the fractional flow reserve (FFR) is lacking.

Methods:

FFR was determined in 10 SVG lesions of 10 males who had stress myocardial perfusion imaging (MPI) prior to referral for percutaneous coronary intervention for clinical indications.

Results:

All SVGs had a diameter stenosis (DS) >50% and 30% had a DS ≥70%. A significant FFR was present in 30% of patients. Ischemia along the territory of the SVG was present in 20% of patients. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of FFR <0.75 for the detection of ischemia on stress MPI were 50, 75, 33, 85, and 70%, respectively. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of FFR <0.75 for detecting ≥70% DS on angiography were 33, 71, 33, 71, and 60%, respectively. There was no significant correlation between FFR and % DS (R2 = 0.1, P = 0.35).

Conclusion:

The use of FFR to assess the physiological significance of SVG lesions is feasible and provides an acceptable specificity and negative predictive value compared to stress MPI. © 2008 Wiley‐Liss, Inc.
Percutaneous rescue of left ventricular embolized amplatzer septal occluder device
Authors: Balbi Manrico , Pongiglione Giacomo , Bezante Gian Paolo
Published: July 2008

Transcatheter atrial septal defect (ASD) closure has proven to be safe and effective, and it is rapidly becoming the standard treatment for secundum‐type ASDs. However, device embolization occurs in about 0.55% of cases, regardless of ASD and device size and/or physician's expertise. Percutaneous retrieval of the embolized device is possible in about 50% of cases, and several techniques have been described, including the use of large sheaths, gooseneck snares, or bioptomes. This is the first successful and reported case of retrieval of an embolized amplatzer septal occluder (ASO) from the left ventricle that was achieved by using a modified snare technique. This was done after an unsuccessful attempt at retrieval with a bioptome that led to a never previously reported complication. Of the 32 reported cases of ASO embolization, percutaneous retrieval was successful in 16 cases (50%) and none were obtained following left ventricular embolization. Even in experienced hands, the observed rate of embolization when using an ASO device is not negligible. Percutaneous retrieval is also possible from the left ventricle but in some cases nonstandardized devices and strategies may be required. © 2008 Wiley‐Liss, Inc.
Long‐term follow‐up of the STARFlex® device for closure of secundum atrial septal defect
Authors: Law M.A. , Josey J. , Justino H. , Mullins C.E. , Ing F.F. , Nugent A.W.
Published: July 2008

Background:

There is limited published outcome data on the STARFlex® device for transcatheter closure of atrial septal defects (ASD).

Aim:

To contribute to the long term outcomes of ASD device closure with the STARFlex® device.

Methods:

Results of a prospective FDA approved clinical trial (1999–2001) from a single institution of the STARFlex device for simple ASD was reviewed. The inclusion criteria included age ≥2 years, isolated secundum ASD, evidence of right ventricular volume overload, and maximum stretched diameter <22 mm. A retrospective review of the original study data with most recent follow‐up was performed. Clinical success in the trial was defined as complete closure or residual leak ≤2 mm, absence of a severe complication and no need for an additional device or surgery to treat the ASD.

Results:

Twenty seven (27) patients were prospectively enrolled in the study period with a procedural success in 23 (85%). There were two severe complications, both 40 mm device embolizations that underwent semiurgent surgical intervention for deviceremoval and ASD closure (40 mm device subsequently withdrawn from trial). Device placement was unsuccessful in two patients due to malposition related to an insufficient retro‐aortic rim, with elective surgical closure. Unsuccessful procedural outcomes were statistically associated with deficient rims (P < 0.01). Of the 23 long term follow‐up device patients, 23 (100%) achieved clinical success: 22 (96%) had complete closure at 1 year and latest echocardiographic follow‐up and one case had a small <2 mm residual defect that has persisted. There have been no late complications with normalization of RV volumes in 92% and no deleterious ECG changes. Device fractures occurred in 8/23 (35%) devices and were more common in the larger devices (P < 0.05) but had no sequalae. None required any further intervention to treat the ASD and there were no infectious or thrombotic issues.

Conclusions:

In this cohort the STARFlex device for secundum ASD closure provided procedural success in 85% with failures due to surgical referral. All 23 patients with a STARFlex device with available long term follow‐up had clinical success. Further long term data is required. © 2009 Wiley‐Liss, Inc.
Coronary no‐reflow phenomenon: From the experimental laboratory to the cardiac catheterization laboratory
Authors: Rezkalla Shereif H. , Kloner Robert A.
Published: July 2008

Coronary no‐reflow occurs commonly during acute percutaneous coronary intervention, particularly in patients with acute myocardial infarction and those with degenerated vein grafts. It is associated with a guarded prognosis, and thus needs to be recognized and treated promptly. The pathophysiology originates during the ischemic phase and is characterized by localized and diffuse capillary swelling and arteriolar endothelial dysfunction. In addition, leukocytes become activated and are attracted to the lumen of the capillaries, exhibit diapedesis and may contribute to cellular and intracellular edema and clogging of vessels. At the moment of perfusion, the sudden rush of leukocytes and distal atheroemboli further contributes to impaired tissue perfusion. Shortening the door‐to‐balloon time, use of glycoprotein IIb/IIIa platelet receptor inhibitors and distal protection devices are predicted to limit the development of no‐reflow during percutaneous interventions. Distal intracoronary injection of verapamil, nicardipine, adenosine, and nitroprusside may improve coronary flow in the majority of patients. Hemodynamic support of the patient may be needed in some cases until coronary flow improves. © 2008 Wiley‐Liss, Inc.
ChemInform Abstract: A Comparative Study of GaAsO4 Polymorphs: Ab initio Calculations on High‐Pressure Forms.
Authors: Arroyo y de Dompablo Elena , Moran Emilio
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Interpenetrating Networks of Three‐Dimensional Penrose Tiles in CaAu3Ga, the Structurally Simplest Cubic Approximant of an Icosahedral Quasicrystal.
Authors: Lin Qisheng , Corbett John D.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Structure of the New Compound Pb3+xSb3‐xS7‐xCl1+x (x≈0.45): The Homologous Series Pb(2+2N)(Sb,Pb)(2+2N)S(2+2N)(S,Cl) (4+2N)ClN and Its Polychalcogenide Derivatives (N = 1—3).
Authors: Doussier Charlotte , Moelo Yves , Meerschaut Alain , Leone Philippe , Guillot‐Deudon Catherine
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: F5SN(H)Xe+; a Rare Example of Xenon Bonded to sp3‐Hybridized Nitrogen; Synthesis and Structural Characterization of [F5SN(H)Xe][AsF6].
Authors: Smith Gregory L. , Mercier Helene P. A. , Schrobilgen Gary J.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Topotactic Insertion of Lithium in the Layered Structure Li4VO(PO4)2: The Tunnel Structure Li5VO(PO4)2.
Authors: Kishore M. Satya , Pralong V. , Caignaert V. , Malo S. , Hebert S. , Varadaraju U. V. , Raveau B.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of an N‐Mesityl Substituted Chiral Imidazolium Salt for NHC‐Catalyzed Reactions.
Authors: Struble Justin R. , Kaeobamrung Juthanat , Bode Jeffrey W.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cerium Alkoxides—Synthesis, Properties and Their Use in Michael Addition Reaction.
Authors: Athar Taimur , Reddy K. Ravinder
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Direct Carbocyclization of Aldehydes with Alkynes: Combining Gold Catalysis with Aminocatalysis.
Authors: Binder Joerg T. , Crone Benedikt , Haug Timm T. , Menz Helge , Kirsch Stefan F.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Et2Zn‐Mediated Rearrangement of Bromohydrins.
Authors: Li Lezhen , Cai Peijie , Guo Qingxiang , Xue Song
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium Nanoclusters Supported on Propylurea‐Modified Siliceous Mesocellular Foam for Coupling and Hydrogenation Reactions.
Authors: Erathodiyil Nandanan , Ooi Samuel , Seayad Abdul M. , Han Yu , Lee Su Seong , Ying Jackie Y.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Construction of a Chiral Quaternary Carbon Center by Indium‐Catalyzed Asymmetric α‐Alkenylation of β‐Ketoesters.
Authors: Fujimoto Taisuke , Endo Kohei , Tsuji Hayato , Nakamura Masaharu , Nakamura Eiichi
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 3‐Trifluoromethanesulfonamido‐pyrrolidine: A General Organocatalyst for anti‐Selective Mannich Reactions.
Authors: Pouliquen Mickael , Blanchet Jerome , Lasne Marie‐Claire , Rouden Jacques
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diastereoselective Ru‐Catalyzed Cross‐Metathesis—Dihydroxylation Sequence. An Efficient Approach Toward Enantiomerically Enriched syn‐Diols.
Authors: Neisius N. Matthias , Plietker Bernd
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Oxidative Generation of Ammonium Ylides and the Subsequent Silicon Polonovski Reaction.
Authors: Honda Kiyoshi , Shibuya Hiromasa , Hoshino Yujiro , Inoue Seiichi
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Realization of anti‐SN2′ Selective Allylation of 4‐Cyclopentene‐1,3‐diol Monoester with Aryl‐ and Alkenyl‐Zinc Reagents.
Authors: Nakata Kenya , Kiyotsuka Yohei , Kitazume Tomoya , Kobayashi Yuichi
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chiral Sterically Congested Phosphane‐Amide Bifunctional Organocatalysts in Asymmetric Aza‐Morita—Baylis—Hillman Reactions of N‐Sulfonated Imines with Methyl and Ethyl Vinyl Ketones.
Authors: Guan Xiao‐Yang , Jiang Ying‐Qing , Shi Min
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Difluoro‐λ3‐Bromane‐Induced Oxidative Carbon—Carbon Bond‐Forming Reactions: Ethanol as an Electrophilic Partner and Alkynes as Nucleophiles.
Authors: Ochiai Masahito , Yoshimura Akira , Mori Takeshi , Nishi Yoshio , Hirobe Masaya
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Cyanomethylation of Carbonyl Compounds and Imines with Highly Basic Phosphine.
Authors: Matsukawa Satoru , Kitazaki Eri
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Biphenyl Anilines Using Iodo Phenylformamides via a One‐Pot Suzuki Coupling Reaction.
Authors: Zhu Lei , Patel Manoj , Zhang Mingbao
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Acceleration of Arylzinc Formation and Its Enantioselective Addition to Aldehydes by Microwave Irradiation and Aziridine‐2‐methanol Catalysts.
Authors: Braga Antonio L. , Paixao Marcio W. , Westermann Bernhard , Schneider Paulo H. , Wessjohann Ludger A.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave‐Mediated Facile Synthesis of Steroid‐Like 1,5‐Diketones from Mannich Salts.
Authors: Rao H. Surya Prakash , Poonguzhali E. , Senthilkumar S. P.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Method to Convert Lactams and Amides into 2,2‐Dialkylated Amines.
Authors: Agosti Alessandro , Britto Sebastian , Renaud Philippe
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Thiacalix[3]pyridine Copper(I) Complex as a Highly Active Catalyst for the Olefin Aziridination Reaction.
Authors: Tsukahara Yuhei , Hirotsu Masakazu , Hattori Shin‐ichi , Usuki Yoshinosuke , Kinoshita Isamu
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactivity of N‐(ω‐Haloalkyl)‐β‐lactams with Regard to Lithium Aluminum Hydride: Novel Synthesis of 1‐(1‐Aryl‐3‐hydroxypropyl)aziridines and 3‐Aryl‐3‐(N‐propylamino)propan‐1‐ols.
Authors: D'hooghe Matthias , Dekeukeleire Stijn , De Kimpe Norbert
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Iodoetherification—Dehydroiodination Strategy for the Synthesis of Complex Spiroketals from Dihydroxyalkene Precursors.
Authors: Tony K. A. , Li Xiaohua , Dabideen Darrin , Li Jialiang , Mootoo David R.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: p‐TsOH‐Catalyzed Efficient Synthesis of Bis(indolyl)methanes.
Authors: Raju B. China , Rao J. Madhusudana
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Intramolecular Diamination of Alkenes with Palladium(II)/Copper(II) Bromide and IPy2BF4: The Role of Halogenated Intermediates.
Authors: Muniz Kilian , Hoevelmann Claas H. , Campos‐Gomez Esther , Barluenga Jose , Gonzalez Jose M. , Streuff Jan , Nieger Martin
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Biological Activity of 4‐Thiazolidones.
Authors: Gurav V. M. , Huge K. G. , Kondaya G. C.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Quick and Highly Efficient Copper‐Catalyzed Cycloaddition of Aliphatic and Aryl Azides with Terminal Alkynes “on Water”.
Authors: Wang Feng , Fu Hua , Jiang Yuyang , Zhao Yufen
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Silica‐Supported ICl as a Novel Heterogeneous System for the Rapid Oxidation of Urazoles to Triazolinediones.
Authors: Karami Bahador , Mallakpour Shadpour , Farahi Mahnaz
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Butenolides as Seed Germination Stimulants.
Authors: Sun Kingmo , Chen Yuzhong , Wagerle Ty , Linnstaedt David , Currie Martin , Chmura Preston , Song Ying , Xu Ming
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Stereodefined 1‐Aryl(heteroaryl) Substituted 1,2‐Bis(2‐bromopyridin‐3‐yl)ethenes by Selective Tandem Suzuki—Miyaura Cross‐Coupling Reactions.
Authors: Chelucci Giorgio , Baldino Salvatore
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 1,2‐Dihydroisoquinolines via Palladium(0)‐Catalyzed Addition—Cyclization of Chloroform to ortho‐Alkynylaldimines.
Authors: Nakamura Hiroyuki , Saito Hiroyuki , Nanjo Masato
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Method for Construction of Tetrahydroisoquinoline Skeleton via Double Cyclization Process Using ortho‐Vinylbenzaldehydes and Amino Alcohols: Application to the Synthesis of (S)‐Cryptostyline II.
Authors: Umetsu Kazuteru , Asao Naoki
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Novel 3‐Substituted Derivatives of 2H‐Pyrano[2,3‐b]pyridine‐2‐one Moiety.
Authors: Kumar Nalam Vasanth , Mashelkar Uday C.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Evaluation of Pharmacological Activity of Some New Aminopyrimidine and Thiopyrimidine Derivatives.
Authors: Patel M. R. , Akbari J. D. , Purohit D. H. , Joshi H. S.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Antiinflammatory Activity of Some Pyrimidines and Thienopyrimidines Using 1‐(2‐((Benzo[d] [1,3]dioxol‐5‐yl)vinyl)‐4‐mercapto‐6‐methylpyrimidine‐5‐yl)ethan‐2‐one as a Starting Material.
Authors: Ouf Nabil H. , Amr Abd El‐Galil E.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Diazaheterocyclic Ring‐Fused 1,2,4‐Benzothiadiazine 1,1‐Dioxides by a Sequential Aza‐Wittig/NH‐Addition Cyclization/Nucleophilic Ring‐Closure Methodology with N‐Alkenyl‐2‐carbodiimidobenzenesulfonamides as Key Intermediates.
Authors: Hirota Shinsuke , Kato Ryo , Suzuki Madoka , Soneta Yuji , Otani Takashi , Saito Takao
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Further Cytotoxic Sesquiterpene Lactones from Elephantopus mollis Kunth.
Authors: Tabopda Turibio Kuiate , Ngoupayo Joseph , Liu Jiawei , Ali Muhammad Shaiq , Khan Shamsun Nahar , Ngadjui Bonaventure Tchaleu , Luu Bang
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Synthesis of Spiruchostatin B, a Potent Histone Deacetylase Inhibitor, from a Microorganism.
Authors: Takizawa Toshiya , Watanabe Kazuhiro , Narita Koichi , Oguchi Takamasa , Abe Hideki , Katoh Tadashi
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient 1,2,4‐Triazine‐Based Route to the Louisianin Alkaloids.
Authors: Catozzi Nicola , Wasnaire Pierre , Taylor Richard J. K.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of (+)‐Obtusenyne.
Authors: Mak S. Y. Frankie , Curtis Neil R. , Payne Andrew N. , Congreve Miles S. , Wildsmith Andrew J. , Francis Craig L. , Davies John E. , Pascu Sofia I. , Burton Jonathan W. , Holmes Andrew B.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Luminescent Properties of Nanosized YVO4:Ln (Ln: Sm, Dy).
Authors: Zhang Hongwu , Fu Xiaoyan , Niu Shuyun , Xin Qin
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Biological Activity of 3H‐1,5‐Benzodiazepine Derivatives.
Authors: Kumar Rajesh , Joshi Y. C.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: High Magnetic Field Superconducting Magnet Technology and Its Applications
Authors: Wang Q. , Dai Y. , Song S. , Lei Y. , Zhao B. , Wang H. , He C. , Yan L. , Lin L.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Critical Review: Life‐Cycle Inventory Procedures for Long‐Term Release of Metals
Authors: Pettersen Johan , Hertwich Edgar G.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Properties of DNA Analogues Consisting of the Benzene‐Phosphate Backbone
Authors: Ueno Yoshihito , Kato Takumi , Sato Kumiko , Ito Yasutomo , Ebihara Masahiro , Jiye Jin , Kitade Yukio
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Glycosylation on Polymer Supports
Authors: Bufali Simone , Seeberger Peter H.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Strategies for the Synthesis of the Novel Antitumor Agent Peloruside A
Authors: Williams David R. , Nag Partha P. , Zorn Nicolas
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Benzazetines and Their Derivatives
Authors: Potkin V. I. , Kaberdin R. V.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Encapsulation of Organic and Inorganic Anions: Synthesis of Macropolycyclic Ligands and Their Anion‐Receptor Properties
Authors: Voloshin Ya. Z. , Belov A. S.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalysis by Palladium Complexes: New Prospects in Amination of Aryl and Hetaryl Chlorides.
Authors: Abaev V. T. , Serdyuk O. V.
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Therapeutics Targeting Tumor Immune Escape: Towards the Development of New Generation Anticancer Vaccines
Authors: Mocellin Simone , Nitti Donato
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Genetically Encoded Calcium Indicators
Authors: Mank Marco , Griesbeck Oliver
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Membranes and Membrane Processes for Chiral Resolution
Authors: Xie Rui , Chu Liang‐Yin , Deng Jin‐Gen
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Torsion Angle Determination by Solid‐State NMR
Authors: Hong Mei
Published: July 2008

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Design and Synthesis of Aryl Ether Inhibitors of the Bacillus Anthracis Enoyl‐ACP Reductase
Authors: Tipparaju Suresh K. , Mulhearn Debbie C. , Klein Gary M. , Chen Yufeng , Tapadar Subhasish , Bishop Molly H. , Yang Shuo , Chen Juan , Ghassemi Mahmood , Santarsiero Bernard D. , Cook James L. , Johlfs Mary , Mesecar Andrew D. , Johnson Michael E. , Kozikowski Alan P.
Published: July 2008

The problem of increasing bacterial resistance to the current generation of antibiotics is well documented. Known resistant pathogens such as methicillin‐resistant Staphylococcus aureus are becoming more prevalent, while the potential exists for developing drug‐resistant pathogens for use as bioweapons, such as Bacillus anthracis. The biphenyl ether antibacterial agent, triclosan, exhibits broad‐spectrum activity by targeting the fatty acid biosynthetic pathway through inhibition of enoyl‐acyl carrier protein reductase (ENR) and provides a potential scaffold for the development of new, broad‐spectrum antibiotics. We used a structure‐based approach to develop novel aryl ether analogues of triclosan that target ENR, the product of the fabI gene, from B. anthracis (BaENR). Structure‐based design methods were used for the expansion of the compound series including X‐ray crystal structure determination, molecular docking, and QSAR methods. Structural modifications were made to both phenyl rings of the 2‐phenoxyphenyl core. A number of compounds exhibited improved potency against BaENR and increased efficacy against both the Sterne strain of B. anthracis and the methicillin‐resistant strain of S. aureus. X‐ray crystal structures of BaENR in complex with triclosan and two other compounds help explain the improved efficacy of the new compounds and suggest future rounds of optimization that might be used to improve their potency.
Morphological analysis of the mormyrid cerebellum using immunohistochemistry, with emphasis on the unusual neuronal organization of the valvula
Authors: Meek Johannes , Yang Jianji Y. , Han Victor Z. , Bell Curtis C.
Published: July 2008

This study used immunohistochemistry, Golgi impregnation, and electron microscopy to examine the circuitry of the cerebellum of mormyrid fish. We used antibodies against the following antigens: the neurotransmitters glutamate and γ‐aminobutyric acid (GABA); the GABA‐synthesizing enzyme glutamic acid decarboxylase (GAD); GABA transporter 1; the anchoring protein for GABA and glycine receptors, gephyrin; the calcium binding proteins calbindin and calretinin; the NR1 subunit of the N‐methyl‐D‐aspartate glutamate receptor; the metabotropic glutamate receptors mGluR1α and mGluR2/3; the intracellular signaling molecules calcineurin and calcium calmodulin kinase IIα (CAMKIIα); and the receptor for inositol triphosphate (IP3RIα). Purkinje cells are immunoreactive to anti‐IP3R1α, anticalcineurin, and anti‐mGluR1α. Cerebellar efferent cells (eurydendroid cells) are anticalretinin and anti‐NR1 positive in the valvula but not in the corpus and caudal lobe. In contrast, climbing fibers are anticalretinin and anti‐NR1 immunopositive in the corpus and caudal lobe but not in the valvula. Purkinje cells, Golgi cells, and stellate cells are GABA positive, whereas efferent cells are glutamate positive. Unipolar brush cells are immunoreactive to anti‐mGluR2/3, anticalretinin, and anticalbindin. We describe a “new” cell type in the mormyrid valvula, the deep stellate cell. These cells are GABA, calretinin, and calbindin positive. They are different from superficial stellate cells in having myelinated axons that terminate massively with GAD‐ and gephyrin‐positive terminals on the cell bodies and proximal dendrites of efferent cells. We discuss how the valvula specializations described here may act in concert with the palisade pattern of Purkinje cell dendrites for analyzing spatiotemporal patterns of parallel fiber activity. J. Comp. Neurol. 510:396–421, 2008. © 2008 Wiley‐Liss, Inc.
Investigation of the Benzene–Naphthalene and Naphthalene–Naphthalene Potential Energy Surfaces: DFT/CCSD(T) Correction Scheme
Authors: Rubeš Miroslav , Bludský Ota , Nachtigall Petr
Published: July 2008

The potential energy surfaces of the naphthalene dimer and benzene–naphthalene complexes are investigated using the recently developed DFT/CCSD(T) correction scheme [J. Chem. Phys. 2008, 128, 114 102]. One and three minima are located on the PES of the benzene–naphthalene and the naphthalene dimer complexes, respectively, all of which are of the parallel‐displaced type. The stabilities of benzene–naphthalene and the naphthalene dimer are −4.2 and −6.2 kcal mol−1, respectively. Unlike the benzene dimer, where the T‐shaped complex is the global minimum, the lowest‐energy T‐shaped structure is about 0.2 and 1.6 kcal mol−1 above the global minimum on the benzene–naphthalene and the naphthalene dimer potential energy surfaces, respectively.
Indirect photometric detection of anions in nonaqueous capillary electrophoresis employing Orange G as probe and a light‐emitting diode‐based detector
Authors: Blanco Heras Gustavo A. , Breadmore Michael C. , Johns Cameron , Hutchinson Joseph P. , Hilder Emily F. , López‐Mahía Purificación , Haddad Paul R.
Published: July 2008

A method based on indirect photometric detection (IPD) in CE employing a blue LED (473 nm) as a light source and the highly absorbing (478 nm) anionic dye, Orange G, as the probe ion was developed for the sensitive analysis of inorganic and organic anions. The use of nonaqueous solvents was examined as a simple way to reduce the adsorption of the dye onto the capillary wall and to thereby improve the baseline stability. The benefits of this approach were confirmed by experiments using BGEs in methanol (MeOH) and DMSO in which superior baselines were obtained relative to those achieved using aqueous electrolyte systems. A range of commercial LEDs was tested to improve the detection performance, with a difference of 25% in sensitivity being observed between the best and worst performing LED. The final system (4 mM Orange G, 0.05% w/v hydroxypropylcellulose (HPC), 20 mM triethanolamine (TEA) in pure MeOH) exhibited stable baselines and very low LODs (0.10–0.18 μM) for a test mixture comprising nine inorganic and organic anions. These values represent a two‐ to six‐fold improvement over previous studies and the proposed method provides the most sensitive IPD method for the determination of anions using CE published to date. RSDs for ten replicates were in the ranges of 0.42–0.62% for migration time, 1.41–3.46% for peak area and 3.20–5.78% for peak height.
The noncoding RNA, miR‐126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3‐kinase signaling and is frequently lost in colon cancers
Authors: Guo Chunguang , Sah Jerome F. , Beard Lydia , Willson James K. V. , Markowitz Sanford D. , Guda Kishore
Published: July 2008

MicroRNAs (miRNA/miR) are a class of small noncoding RNAs implicated in the pathogenesis of various malignancies. In the current study, using micro(RNA) arrays, we found a ubiquitous loss of miR‐126 expression in colon cancer lines when compared to normal human colon epithelia. Reconstitution of miR‐126 in colon cancer cells resulted in a significant growth reduction as evidenced in clonogenic assays. A search for miR‐126 gene targets revealed p85β, a regulatory subunit involved in stabilizing and propagating the phosphatidylinositol 3‐kinase (PI3K) signal, as one of the potential substrates. Restoration of miR‐126 in cancer cells induced a ≥3‐fold reduction in p85β protein levels, with no concomitant change in p85α, a gene that is functionally related to p85β but not a supposed target of miR‐126. Additionally, using reporter constructs, we show that the p85β‐3′ untranslated region is directly targeted by miR‐126. Furthermore, this miR‐126 mediated reduction of p85β was accompanied by a substantial reduction in phosphorylated AKT levels in the cancer cells, suggesting an impairment in PI3K signaling. Finally, in a panel of matched normal colon and primary colon tumors, each of the tumors demonstrated miR‐126 down‐regulation together with an increase in the p85β protein level. Taken together, we propose that miR‐126 regulates PI3K signaling partly by targeting p85β, and that the loss of miR‐126 may provide a selective growth advantage during colon carcinogenesis. © 2008 Wiley‐Liss, Inc.
Genome‐wide linkage scan in Dutch hereditary non‐BRCA1/2 breast cancer families identifies 9q21‐22 as a putative breast cancer susceptibility locus
Authors: Oldenburg Rogier A. , Kroeze‐Jansema Karin H. G. , Houwing‐Duistermaat Jeanine J. , Bayley Jean‐Pierre , Dambrot Cheryl , van Asperen Christi J. , van den Ouweland Ans M. W. , Bakker Bert , van Beers Erik H. , Nederlof Petra M. , Vasen Hans , Hoogerbrugge Nicoline , Cornelisse Cees J. , Meijers‐Heijboer Hanne , Devilee Peter
Published: July 2008

Breast cancer accounts for over 20% of all female cancers. A positive family history remains one of the most important risk factors for the disease, with first‐degree relatives of patients having a twofold elevated risk. Known breast cancer susceptibility genes such as BRCA1 and BRCA2 explain only 20–25% of this risk, suggesting the existence of other breast cancer susceptibility genes. Here, we report the results of a genome‐wide linkage scan in 55 high‐risk Dutch breast cancer families with no mutations in BRCA1 and BRCA2. Twenty‐two of these families were also part of a previous linkage study by the Breast Cancer Linkage Consortium. In addition, we performed CGH analyses in 61 tumors of these families and 31 sporadic tumors. Three regions were identified with parametric HLOD scores >1, and three with nonparametric LOD scores >1.5. Upon further marker genotyping for the candidate loci, and the addition of another 30 families to the analysis, only the locus on chromosome 9 (9q21‐22, marker D9S167) remained significant, with a nonparametric multipoint LOD score of 3.96 (parametric HLOD 0.56, α = 0.18). With CGH analyses we observed preferential copy number loss at BAC RP11‐276H19, containing D9S167 in familial tumors as compared to sporadic tumors (P < 0.001). Five candidate genes were selected from the region around D9S167 and their coding regions subjected to direct sequence analysis in 16 probands. No clear pathogenic mutations were found in any of these genes. © 2008 Wiley‐Liss, Inc.
Genome‐wide copy number alterations detection in fresh frozen and matched FFPE samples using SNP 6.0 arrays
Authors: Tuefferd Marianne , De Bondt An , Van Den Wyngaert Ilse , Talloen Willem , Verbeke Tobias , Carvalho Benilton , Clevert Djork‐Arne , Alifano Marco , Raghavan Nandini , Amaratunga Dhammika , Göhlmann Hinrich , Broët Philippe , Camilleri‐Broët Sophie
Published: July 2008

SNP arrays offer the opportunity to get a genome‐wide view on copy number alterations and are increasingly used in oncology. DNA from formalin‐fixed paraffin‐embedded material (FFPE) is partially degraded which limits the application of those technologies for retrospective studies. We present the use of Affymetrix GeneChip SNP6.0 for identification of copy number alterations in fresh frozen (FF) and matched FFPE samples. Fifteen pairs of adenocarcinomas with both frozen and FFPE embedded material were analyzed. We present an optimization of the sample preparation and show the importance of correcting the measured intensities for fragment length and GC‐content when using FFPE samples. The absence of GC content correction results in a chromosome specific “wave pattern” which may lead to the misclassification of genomic regions as being altered. The highest concordance between FFPE and matched FF were found in samples with the highest call rates. Nineteen of the 23 high level amplifications (83%) seen using FF samples were also detected in the corresponding FFPE material. For limiting the rate of “false positive” alterations, we have chosen a conservative False Discovery Rate (FDR). We observed better results using SNP probes than CNV probes for copy number analysis of FFPE material. This is the first report on the detection of copy number alterations in FFPE samples using Affymetrix GeneChip SNP6.0. © 2008 Wiley‐Liss, Inc.