bluuebunny/crossref_metadata_2025 huggingface dataset:
Low Temperature Effect on the Mechanical Properties of EH36 with Strain Rates
Authors: Zhang Jing , Kang Xuelei , Shi Xinghua , Guedes Soares C. , Song Ming
Published: March 2023

With the expansion of the Arctic route, the safety of ship crossing the area in light of the low temperature and ice has become of focus, especially with regards to the ship’s structure. The mechanical properties of the material making up the ship’s structure may not be suitable for the Arctic environment. A series of quasi-static and dynamic tests were performed to investigate the behaviour of EH36 steel, which is used to build Arctic ships, at temperatures ranging from 20 °C to −60 °C. The yield and ultimate tensile stress increased more than 10% as the temperature decreased from 20 °C to −60 °C, whereas the toughness decreased as the temperature decreased. A formula was derived to illustrate the relationship between the temperature reduction and the yield strength by fitting the experimental data. Four common constitutive rigid-perfectly plastic, elastic-perfectly plastic, bilinear elastic-plastic, and multi-linear elastic plastic models were fitted to simulate the hull structure under static loading and low temperature. Additionally, the strain rate effect of EH36 steel at low temperatures was illustrated by quasi-static and high-speed impact tests. A constitutive model including the low temperature and strain rate was introduced based on a modified Cowper-Symonds model, in which the coefficients of the constitutive model are fitted by the test results. It is improved by an iterative numerical method used to obtain more accurate coefficients using a series of numerical analyses. Detailed finite element simulations of the experiment conditions revealed that the constitutive model accurately predicts the dynamic response at low temperatures.
Subjective Perception and Psychoacoustic Aspects of the Laryngectomee Voice: The Impact on Quality of Life
Authors: Mesolella Massimo , Allosso Salvatore , D’aniello Roberto , Pappalardo Emanuela , Catalano Vincenzo , Quaremba Giuseppe , Motta Gaetano , Salerno Grazia
Published: March 2023

Purpose: A retrospective study is presented to correlate the inter-judge consistency for the different psycho-perceptual parameters of the recently proposed Impression Noise Fluency Voicing (INFVo) perceptual rating scale for substitution voices, and the vocal function as perceived by the patient. Methods: The scale Voice-Related Quality of Life (V-RQoL) and the Self Evaluation of Communication Experiences After Laryngectomy scale (SECEL)—a self-evaluation questionnaire of communicative experience after laryngectomy surgery—were administered to 89 total laryngectomees, subdivided in four groups depending on their type of alaryngeal voice (i.e., tracheoesophageal and esophageal speakers, electro larynx users, voiceless patients), in order to evaluate the impact of the impairment of the phonatory function on the quality of life. Results: No significant differences exist among the various groups on their perception of QoL using subjective questionnaires, whereas the INFVo scale has proven to be a useful tool for the description and analysis of the psychoacoustic characteristics of the vocal signal and a reliable instrument to correctly classify the patients. It is also notable that the judgement of the patients on their own voice and those of the referees are highly significant. Conclusion: Although speech rehabilitation for the acquisition of a substitution voice offers a new way of communication for the laryngectomized patients, nonetheless, their QoL is not significantly related to the type of substitution voice. Therefore, improving the patient’s adaptation to the new phonatory condition is mandatory.
Effect of Intravitreal Conbercept Injection on Complications of Pars Plana Vitrectomy in Patients with Proliferative Diabetic Retinopathy
Authors: Ding Yuzhi , Su Na , Luan Jie , Ni Yan , Sun Zilin
Published: March 2023

Background: The effect of intravitreal conbercept (IVC) before pars plana vitrectomy (PPV) on surgical complications in patients with proliferative diabetic retinopathy (PDR) was observed. Methods: A total of 152 patients with PDR operated on in Jiangsu Provincial People’s Hospital from November 2019 to November 2020 were divided into two groups: 124 patients in the preoperative intravitreal conbercept injection + PPV group (IVC group) and 28 patients in the PPV only group (No-IVC group). Vitreous samples were collected in all eyes of patients who underwent vitrectomy, and the content of VEGF-A was measured by Luminex. The effect of conbercept on intraoperative and postoperative complications of PDR was assessed. Results: The content of VEGF in the vitreous of the IVC group was significantly lower than that in the No-IVC group (64.50 ± 58.40 pg/mL vs. 805.17 ± 417.60 pg/mL, p < 0.001). During postoperative follow-up, early postoperative vitreous hemorrhage (VH) occurred in 13 of 142 eyes (9.15%). Compared with the No-IVC group, PDR patients with VH and fibrovascular membrane (FVM) or high complexity in the IVC group had lower intraoperative bleeding rates (p < 0.05). The early postoperative hemorrhage rate in the IVC group was lower than in the No-IVC group (6.03% vs. 23.08%, p < 0.05). The number of intraoperative electrocoagulation and iatrogenic retinal holes in the IVC group was significantly lower than in the No-IVC group (p < 0.05). There were no significant differences in intraocular hypertension and NVG numbers between the two groups. Visual acuity in both groups improved after PPV surgery, reaching the highest level in the 3rd month after the operation. Conclusions: IVC before PPV can reduce the level of VEGF-A in the vitreous body and reduce surgical complications.
Co-Opetitive Strategy Optimization for Online Video Platforms with Multi-Homing Subscribers and Advertisers
Authors: Li Jing , Gong Shuying , Li Xing
Published: March 2023

In the two-sided market for online streaming content, the platform’s co-opetitive strategy has been wildly discussed, where the platforms cooperate in sharing the broadcasting right of content and meanwhile compete for both subscribers and advertisers. Although platform co-opetition in practice can be easily captured, the impacts of cross-side network effects on pricing strategy are contingent upon the participation decision of both sides, including single-homing and multi-homing. Therefore, we examine the optimal co-opetitive strategy of duopoly platforms using a Hotelling model to capture user behaviors and investigate the equilibriums of pricing decisions and profits in three scenarios: single-single, multi-single, and multi-multi. The main findings are: (1) Advertisers choose multi-homing only when subscribers are also multi-homing, and the broadcasting cost is relatively low. (2) With single-homing advertisers, the primary broadcasting platform earns more profit than the re-broadcasting one. (3) With multi-homing advertisers, the primary broadcasting platform’s profit increases with the broadcasting rights cost. (4) Platforms should focus on building strong cross-side network effects with multi-homing advertisers. Alternatively, they would be better off contracting with single-homing advertisers if the effects are relatively low.
Urban Forest Tweeting: Social Media as More-Than-Human Communication in Tokyo’s Rinshinomori Park
Authors: Martín Sánchez Diego , Gómez Lobo Noemí
Published: March 2023

Urban parks are places that have significant impact on the physical and mental health of citizens, but they are also for safeguarding biodiversity and thus fostering human–nature interactions in the everyday landscape. The exploration of these spaces through social media represents a novel field of research that is contributing to revealing patterns of visitor behavior. However, there is a lack of comparable research from a non-anthropocentric perspective. What if we could use social media as a more-than-human communication medium? This research aims to reveal the possibility of communicating the urban forest’s voice through the examination of the official Twitter account of a metropolitan park in Tokyo. To this end, an analysis of the content of the messages is carried out, focusing on the narrative voice from which the message is told, the protagonists, the action performed, the network of actors deployed, and the place where it occurs. It is found that the majority of these messages are delivered from a non-human perspective, where plants, animals, or meteorological agents behave deploying complex networks of more-than-human interaction. The current study reveals the latent potential of non-humans as possible agents within the realm of social media, which can mediate the relationships between humans and their environment. It introduces a layer that can be incorporated into future lines of research, as well as provides a model case that illustrates a good practice in the management and communication of urban green spaces.
Risk Scores for Prediction of Major Cardiovascular Events in Non-Alcoholic Fatty Liver Disease: A No Man’s Land?
Authors: Gheorghe Liliana , Nemteanu Roxana , Clim Andreea , Botnariu Gina Eosefina , Costache Irina Iuliana , Plesa Alina
Published: March 2023

Over the past 100 years, cardiovascular disease (CVD) has become a leading cause of mortality and morbidity in developed countries, and similar trends have occurred for chronic liver disease. Subsequent research also indicated that people with non-alcoholic fatty liver disease (NAFLD) had a twofold increased risk of CV events and that this risk was doubled in those with liver fibrosis. However, no validated CVD risk score specific for NAFLD patients has yet been validated, as traditional risk scores tend to underestimate the CV risk in NAFLD patients. From a practical perspective, identifying NAFLD patients and assessing severity of liver fibrosis when concurrent atherosclerotic risk factors are already established may serve as an important criterion in new CV risk scores. The current review aims to assess current risk scores and their utility for the prediction of CV events among patients with NAFLD.
Humic Substances as a Versatile Intermediary
Authors: Hriciková Simona , Kožárová Ivona , Hudáková Nikola , Reitznerová Anna , Nagy Jozef , Marcinčák Slavomír
Published: March 2023

Humic substances are organic ubiquitous components arising in the process of chemical and microbiological oxidation, generally called humification, the second largest process of the carbon cycle. The beneficial properties of these various substances can be observed in many fields of life and health, whether it is the impact on the human organism, as prophylactic as well as the therapeutic effects; animal physiology and welfare, which is widely used in livestock farming; or the impact of humic substances on the environment and ecosystem in the context of renewal, fertilization and detoxification. Since animal health, human health and environmental health are interconnected and mutually influencing, this work brings insight into the excellence of the use of humic substances as a versatile mediator contributing to the promotion of One Health.
Transient Liquid Phase Diffusion Bonding of Ni3Al Superalloy with Low-Boron Nickel-Base Powder Interlayer
Authors: Wen Zhifeng , Li Qi , Liu Fengmei , Dong Yong , Zhang Yupeng , Hu Wei , Li Likun , Gao Haitao
Published: March 2023

As a technology for micro-deformed solid-phase connection, transient liquid phase (TLP) diffusion bonding plays a key role in the manufacture of heating components of aero engines. However, the harmful brittle phase and high hardness limit the application of TLP diffusion bonding in nickel-based superalloys. In this paper, a new strategy in which a low-boron and high-titanium interlayer can restrain the brittle phase and reduce the hardness of the TLP-diffusion-bonded joint is proposed. With this strategy, the Ni3Al joint can achieve a high strength of 860.84 ± 26.9 MPa under conditions of 1250 °C, 6 h and 5 MPa. The microhardness results show that the average microhardness of the joint area is 420.33 ± 3.15 HV and is only 4.3% higher than that of the Ni3Al base material, which proves that this strategy can effectively inhibit the formation of the harmful brittle phase in the joint area. The results of EBSD show that 7.7% of the twin boundaries exist in the isothermal solidification zone, and only small amounts of secondary precipitates are observed at the grain boundaries in the joint, which indicates that twin boundaries may play a dominant role in crack initiation. This study provides a feasible avenue to suppress the brittle phase in TLP-diffusion-bonded joints.
Saturated and Polyunsaturated Fatty Acids Production by Aurantiochytrium limacinum PKU#Mn4 on Enteromorpha Hydrolysate
Authors: He Yaodong , Zhu Xingyu , Ning Yaodong , Chen Xiaohong , Sen Biswarup , Wang Guangyi
Published: March 2023

Thraustochytrids are unicellular marine heterotrophic protists, which have recently shown a promising ability to produce omega-3 fatty acids from lignocellulosic hydrolysates and wastewaters. Here we studied the biorefinery potential of the dilute acid-pretreated marine macroalgae (Enteromorpha) in comparison with glucose via fermentation using a previously isolated thraustochytrid strain (Aurantiochytrium limacinum PKU#Mn4). The total reducing sugars in the Enteromorpha hydrolysate accounted for 43.93% of the dry cell weight (DCW). The strain was capable of producing the highest DCW (4.32 ± 0.09 g/L) and total fatty acids (TFA) content (0.65 ± 0.03 g/L) in the medium containing 100 g/L of hydrolysate. The maximum TFA yields of 0.164 ± 0.160 g/g DCW and 0.196 ± 0.010 g/g DCW were achieved at 80 g/L of hydrolysate and 40 g/L of glucose in the fermentation medium, respectively. Compositional analysis of TFA revealed the production of equivalent fractions (% TFA) of saturated and polyunsaturated fatty acids in hydrolysate or glucose medium. Furthermore, the strain yielded a much higher fraction (2.61–3.22%) of eicosapentaenoic acid (C20:5n-3) in the hydrolysate medium than that (0.25–0.49%) in the glucose medium. Overall, our findings suggest that Enteromorpha hydrolysate can be a potential natural substrate in the fermentative production of high-value fatty acids by thraustochytrids.
A Critical Review on Fiber Metal Laminates (FML): From Manufacturing to Sustainable Processing
Authors: Costa Rúben D. F. S. , Sales-Contini Rita C. M. , Silva Francisco J. G. , Sebbe Naiara , Jesus Abílio M. P.
Published: March 2023

Composite materials such as Fiber Metal Laminates (FMLs) have attracted the interest of the aerospace and automotive industries due to their high strength to weight ratio, but to use them as structures it is necessary to master the manufacturing and wiring techniques of these materials. Therefore, this paper aims to address and summarize the drilling and milling processes in FMLs based on a literature review of papers published from 2000 to 2023. Parameters used in multi-material manufacturing and machining such as drilling and milling, tool geometry, tool coating, lubricants and coolants published by researchers were analyzed, compared and discussed. Machining process parameters related to sustainability were also analyzed. A SWOT analysis was carried out and discussed to identify opportunities for improvement in the machining process. There are opportunities to develop the surface treatment of aluminum alloys, such as testing other combinations than those already used, testing non-traditional surface treatments and manufacturing modes, and developing sustainable techniques during the FML manufacturing process. In the area of tooling, the opportunities are mainly related to coatings for tools and changing machining parameters to achieve an optimum finished part. Finally, to improve the sustainability of the process, it is necessary to test coated drills under cryogenic conditions to reduce the use of lubricants during the machining process.
Untangling the Complexities of Processing and Analysis for Untargeted LC-MS Data Using Open-Source Tools
Authors: Parker Elizabeth J. , Billane Kathryn C. , Austen Nichola , Cotton Anne , George Rachel M. , Hopkins David , Lake Janice A. , Pitman James K. , Prout James N. , Walker Heather J. , Williams Alex , Cameron Duncan D.
Published: March 2023

Untargeted metabolomics is a powerful tool for measuring and understanding complex biological chemistries. However, employment, bioinformatics and downstream analysis of mass spectrometry (MS) data can be daunting for inexperienced users. Numerous open-source and free-to-use data processing and analysis tools exist for various untargeted MS approaches, including liquid chromatography (LC), but choosing the ‘correct’ pipeline isn’t straight-forward. This tutorial, in conjunction with a user-friendly online guide presents a workflow for connecting these tools to process, analyse and annotate various untargeted MS datasets. The workflow is intended to guide exploratory analysis in order to inform decision-making regarding costly and time-consuming downstream targeted MS approaches. We provide practical advice concerning experimental design, organisation of data and downstream analysis, and offer details on sharing and storing valuable MS data for posterity. The workflow is editable and modular, allowing flexibility for updated/changing methodologies and increased clarity and detail as user participation becomes more common. Hence, the authors welcome contributions and improvements to the workflow via the online repository. We believe that this workflow will streamline and condense complex mass-spectrometry approaches into easier, more manageable, analyses thereby generating opportunities for researchers previously discouraged by inaccessible and overly complicated software.
Integrative Transcriptomic and Metabolomic Analysis Reveals the Molecular Mechanism of Red Maple (Acer rubrum L.) Leaf Coloring
Authors: Luo Yuanyuan , Deng Min , Zhang Xia , Zhang Damao , Cai Wenqi , Long Yuelin , Xiong Xingyao , Li Yanlin
Published: March 2023

This study employed a combination of ultraviolet spectrophotometry, LC-ESI-MS/MS system, and RNA-sequencing technology; the extracts and isolation of total RNA from the red and yellow leaf strains of red maple (Acer rubrum L.) at different developmental stages were subjected to an intercomparison of the dynamic content of chlorophyll and total anthocyanin, flavonoid metabolite fingerprinting, and gene expression. The metabonomic results indicated that one hundred and ninety-two flavonoids were identified, which could be classified into eight categories in the red maple leaves. Among them, 39% and 19% were flavones and flavonols, respectively. The metabolomic analysis identified 23, 32, 24, 24, 38, and 41 DAMs in the AR1018r vs. AR1031r comparison, the AR1018r vs. AR1119r comparison, the AR1031r vs. AR1119r comparison, the AR1018y vs. AR1031y comparison, the AR1018y vs. AR1119y comparison, and the AR1031y vs. AR1119y comparison, respectively. In total, 6003 and 8888 DEGs were identified in AR1018r vs. AR1031r comparison and in the AR1018y vs. AR1031y comparison, respectively. The GO and KEGG analyses showed that the DEGs were mainly involved in plant hormone signal transduction, flavonoid biosynthesis, and other metabolite metabolic processes. The comprehensive analysis revealed that caffeoyl-CoA 3-O-methyltransferase (Cluster-28704.45358 and Cluster-28704.50421) was up-regulated in the red strain but down-regulated in the yellow strain, while Peonidin 3-O-glucoside chloride and Pelargonidin 3-O-beta-D-glucoside were up-regulated in both the red and yellow strains. By successfully integrating the analyses on the behavior of pigment accumulation, dynamics of flavonoids, and differentially expressed genes with omics tools, the regulation mechanisms underlying leaf coloring in red maple at the transcriptomic and metabolomic levels were demonstrated, and the results provide valuable information for further research on gene function in red maple.
Fluorescence Properties of ZnOQDs-GO-g-C3N4 Nanocomposites
Authors: Liu Tianze , Wang Lei , Jiang Ruxue , Tang Yashi , He Yuxin , Sun Changze , Lv Yuguang , Liu Shuang
Published: March 2023

In this paper, the fluorescence properties of ZnOQD-GO-g-C3N4 composite materials (ZCGQDs) were studied. Firstly, the addition of a silane coupling agent (APTES) in the synthesis process was explored, and it was found that the addition of 0.04 g·mL−1 APTES had the largest relative fluorescence intensity and the highest quenching efficiency. The selectivity of ZCGQDs for metal ions was also investigated, and it was found that ZCGQDs showed good selectivity for Cu2+. ZCGQDs were optimally mixed with Cu2+ for 15 min. ZCGQDs also had good anti-interference capability toward Cu2+. There was a linear relationship between the concentration of Cu2+ and the fluorescence intensity of ZCGQDs in the range of 1~100 µM. The regression equation was found to be F0/F = 0.9687 + 0.12343C. The detection limit of Cu2+ was about 1.74 μM. The quenching mechanism was also analyzed.
Tick Populations and Molecular Analysis of Anaplasma Species in Ticks from the Republic of Korea
Authors: Seo Min-Goo , Lee Haeseung , Alkathiri Badriah , Ahn KyuSung , Lee Seung-Hun , Shin SungShik , Bae Seulgi , Kim Kyoo-Tae , Jang Min , Lee Sang-Kwon , Cho Yun Sang , Eo Kyung-Yeon , Kwon Oh-Deog , Kwak Dongmi
Published: March 2023

The present study was performed to survey the dominant tick populations and molecularly determine the pathogenic agents of anaplasmosis in ticks from Gyeongsang, Republic of Korea. A total of 3825 questing ticks were collected by the flagging method from 12 sites near animal farms in Gyeongsang from March to October 2021. A molecular genomic study was performed with ticks stored in 70% ethanol to detect Anaplasma genes by the previously described method. The monthly incidence of ticks varied by developmental stages, i.e., nymphs, adults, and larvae, and each of their populations peaked in May, March, and October, respectively. The predominant tick species were Haemaphysalis longicornis, Haemaphysalis sp., Haemaphysalis flava, Ixodes nipponensis, and Amblyomma testudinarium in order. To determine the Anaplasma infection rate, collected ticks were pooled into 395 groups. The minimum infection rate (MIR) of Anaplasma was 0.7% (27 pools). That of A. phagocytophilum was highest (23 pools, MIR 0.6%), followed by A. phagocytophilum-like Anaplasma spp. clade B (2 pools, MIR 0.1%), A. bovis (1 pool, MIR 0.1%), and A. capra (1 pool, MIR 0.1%), respectively. In this study, five species of ticks, including unidentified Haemaphysalis species, were collected in 12 survey sites in Gyeongsang, but their prevalence was somewhat different according to the tick species and survey sites. Further, the incidence rate (6.8%) of 4 Anaplasma spp. was not as high in tick pools. However, the results of this study may offer a basis for future epidemiological research and risk assessment of tick-borne diseases.
Targeted HPTLC Profile, Quantification of Flavonoids and Phenolic Acids, and Antimicrobial Activity of Dodonaea angustifolia (L.f.) Leaves and Flowers
Authors: Tessema Fekade Beshah , Gonfa Yilma Hunde , Asfaw Tilahun Belayneh , Tadesse Mesfin Getachew , Tadesse Tigist Getachew , Bachheti Archana , Alshaharni Mohammed O. , Kumar Pankaj , Kumar Vinod , Širić Ivan , Abou Fayssal Sami , Chaubey Kundan Kumar , Bachheti Rakesh Kumar
Published: March 2023

In East Africa, Dodonaea angustifolia (L.f.) is a well-known medicinal herb. Its leaf is primarily studied in light of its ethnobotanical use. In terms of phytochemistry and biological activity, its flower is not studied. In a prior study, our team looked into phytochemical screening, antioxidant activity, and total phenolic levels. This study aims to compare the profiles and biological activities of the leaf and flower samples of D. angustifolia and to present therapeutic alternatives. The leaf and flower sample powders were extracted with methanol using ultrasound-assisted extraction (UAE). HPTLC profile was obtained using CAMAG—HPTLC equipped with VisionCATS software. Antimicrobial agar well diffusion assay and minimum inhibition concentration (MIC) were determined. The leaf and flower extracts of D. angustifolia showed antibacterial activity with a MIC value of 20 µg/mL against Enterococcus faecalis and Listeria monocytogenes. Similarly, 40 µg/mL was found to be effective against Aspergillus flavus. D. angustifolia flower is a rich source of flavonoids and phenolic acids. Because of its antibacterial properties and profile, which are almost the same, the flower is emerging as a viable option for medicinal alternatives.
Bioactive Compounds, Antioxidant Activities, and HPLC Analysis of Nine Edible Sprouts in Cambodia
Authors: So Visessakseth , Poul Philip , Oeung Sokunvary , Srey Pich , Mao Kimchhay , Ung Huykhim , Eng Poliny , Heim Mengkhim , Srun Marnick , Chheng Chantha , Chea Sin , Srisongkram Tarapong , Weerapreeyakul Natthida
Published: March 2023

The non-nutritional health benefits of sprouts are unconfirmed. Thus, nine sprout methanolic extracts were tested for phytoconstituents and antioxidant activity. The TPC, TCC, TFC, TAC, and TALC were measured. ABTS and DPPH radical scavenging and ferric-reducing antioxidant power assays were used to assess the antioxidant activity. HPLC detected gallic acid, vanillin, syringic acid, chlorogenic acid, caffeic acid, and rutin in the extracts. The sprout extracts contained six compounds, with caffeic acid being the most abundant. Gallic acid, syringic acid, chlorogenic acid, caffeic acid, vanillin, and rutin were highest in soybean, black sesame, mustard, sunflower, white radish, and black sesame sprouts, respectively. Sunflower sprouts had the highest level of TCC while soybean sprouts had the highest level of TFC, Taiwanese morning glory had the highest level of TPC, mustard sprouts had the highest level of TALC, and black sesame sprouts had the highest level of TAC. Taiwanese morning glories scavenged the most DPPH and ABTS radicals. Colored and white radish sprouts had similar ferric-reducing antioxidant power. Antioxidation mechanisms varied by compound. Our findings demonstrated that sprouts have biological effects, and their short time for mass production offers an alternative food source for health benefits, and that they are useful for future research development of natural products and dietary supplements.
Effect of Different Time/Temperature Binomials on the Chemical Features, Antioxidant Activity, and Natural Microbial Load of Olive Pomace Paste
Authors: Sousa Maria Manuela , Ferreira Diana Melo , Machado Susana , Lobo Joana C. , Costa Anabela S. G. , Palmeira Josman D. , Nunes Maria Antónia , Alves Rita C. , Ferreira Helena , Oliveira Maria Beatriz P. P.
Published: March 2023

Olive pomace is a by-product from olive oil production that can be further processed to obtain olive pomace paste. In this work, the influence of different time/temperature binomials (65 °C/30 min; 77 °C/1 min; 88 °C/15 s; and 120 °C/20 min) on the nutritional quality, chemical composition, and efficiency on control/elimination of natural microbial load of olive pomace paste was ascertained. The treatments significantly impacted the contents of ash, fat, vitamin E, phenolics (including hydroxytyrosol), flavonoids, and antioxidant activity, but not the fatty acids profile. The binomial 88 °C/15 s showed the greatest potential since it better preserved the phytochemical and antioxidant properties as well as the protein and fiber contents. This binomial is also faster and easy to be implemented at an industrial level, allowing the obtention of a safe functional ingredient to satisfy consumers’ demands for novel sustainable products, simultaneously, responding to food safety and food security concerns.
Rational Fabrication of Defect-Rich and Hierarchically Porous Fe-N-C Nanosheets as Highly Efficient Oxygen Reduction Electrocatalysts for Zinc-Air Battery
Authors: Li Sensen , Lv Yan , Elam Sawida , Zhang Xiuli , Yang Zhuojun , Wu Xueyan , Guo Jixi
Published: March 2023

The rational design of morphology and structure for oxygen reduction reaction (ORR) catalysts still remains a critical challenge. Herein, we successfully construct defect-rich and hierarchically porous Fe-N-C nanosheets (Fe-N-CNSs), by taking advantage of metal-organic complexation and a mesoporous template. Benefiting from the advantages of high density of active sites, fast mass transfer channels, and sufficient reaction area, the optimal Fe-N-CNSs demonstrate satisfactory ORR activity with an excellent half-wave potential of up to 0.87 V, desirable durability, and robust methanol tolerance. Noteworthy, the Fe-N-CNSs based zinc–air battery shows significant performance with a peak power density of 128.20 mW cm−2 and open circuit voltage of 1.53 V, which reveals that the Fe-N-CNSs catalysts present promising practical application prospects. Therefore, we believe that this research will provide guidance for the optimization of Fe-N-C materials.
The Efficiency Study of Graphene Synthesis on Copper Substrate via Chemical Vapor Deposition Method with Methanol Precursor
Authors: Huang Bohr-Ran , Hung Shang-Chao , Ho Yung-Shou , Chen Yi-Siou , Yang Wein-Duo
Published: March 2023

Few-layer graphene was successfully synthesized on copper foil via chemical vapor deposition with methanol as a carbon source. This was confirmed by optical microscopy observation, Raman spectra measurement, I2D/IG ratio calculation, and 2D-FWHM value comparisons. Monolayer graphene was also found in similar standard procedures, but it required higher growth temperature and longer time periods. The cost-efficient growth conditions for few-layer graphene are thoroughly discussed via TEM observation and AFM measurement. In addition, it has been confirmed that the growth period can be shortened by increasing growth temperature. With the H2 gas flow rate fixed at 15 sccm, few-layer graphene was synthesized at the lower growth temperature of 700 °C in 30 min, and at 900 °C growth temperature in only 5 min. Successful growth was also achieved without adding hydrogen gas flow; this is probably because H2 can be induced from the decomposition of methanol. Through further defects study of few-layer graphene via TEM observation and AFM measurement, we tried to find possible ways for efficiency and quality management in graphene synthesis in industrial applications. Lastly, we investigated graphene formation after pre-treatment with different gas compositions, and found that gas selection is a crucial factor for a successful synthesis.
Food, Dietary Patterns, or Is Eating Behavior to Blame? Analyzing the Nutritional Aspects of Functional Dyspepsia
Authors: Amerikanou Charalampia , Kleftaki Stamatia-Angeliki , Valsamidou Evdokia , Chroni Eirini , Biagki Theodora , Sigala Demetra , Koutoulogenis Konstantinos , Anapliotis Panagiotis , Gioxari Aristea , Kaliora Andriana C.
Published: March 2023

Functional dyspepsia is a gastrointestinal disorder characterized by postprandial fullness, early satiation, epigastric pain, and epigastric burning. The pathophysiology of the disease is not fully elucidated and there is no permanent cure, although some therapies (drugs or herbal remedies) try to reduce the symptoms. Diet plays a critical role in either the reduction or the exacerbation of functional dyspepsia symptoms; therefore dietary management is considered to be of high importance. Several foods have been suggested to be associated with worsening functional dyspepsia, such as fatty and spicy foods, soft drinks, and others, and other foods are thought to alleviate symptoms, such as apples, rice, bread, olive oil, yogurt, and others. Although an association between functional dyspepsia and irregular eating habits (abnormal meal frequency, skipping meals, late-night snacking, dining out, etc.) has been established, not many dietary patterns have been reported as potential factors that influence the severity of functional dyspepsia. A higher adherence to Western diets and a lower adherence to FODMAPs diets and healthy patterns, such as the Mediterranean diet, can contribute to the worsening of symptoms. More research is needed on the role of specific foods, dietary patterns, or specific eating habits in the management of functional dyspepsia.
The Potential Use of Honey as a Neuroprotective Agent for the Management of Neurodegenerative Diseases
Authors: Fadzil Mohammad Adi Mohammad , Mustar Suraiami , Rashed Aswir Abd
Published: March 2023

As the global population ages, there is an increasing research on managing neurodegenerative diseases that mainly affect the elderly. Honey is one of the natural products and functional foods widely studied for its neuroprotective properties. This review investigates honey’s effectiveness as a neuroprotective agent through in vitro, in vivo, and clinical research. The articles were browsed from three databases (PubMed, ScienceDirect, and Scopus) between the years of 2012 and 2022 using the keywords “honey” crossed with “neurodegenerative”. Out of the 16 articles, six in vitro, eight in vivo, one combination study, and one clinical intervention were compiled. Among the various types of honey studied, the Tualang and Thyme honey exhibited the highest antioxidant, anti-inflammatory, and anticholinesterase activity, leading to the prevention and management of multiple neurodegenerative diseases such as Alzheimer’s disease. The neuroprotective properties of honey are primarily attributed to its high polyphenol content, with quercetin and gallic acid being the most prominent. This review compiled considerable evidence of the anti-neurodegenerative properties of honey presented by in vitro and in vivo studies. However, more clinical intervention studies are required to support these findings further.
Recent Progress of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Ocular Drug Delivery Platforms
Authors: Gugleva Viliana , Andonova Velichka
Published: March 2023

Sufficient ocular bioavailability is often considered a challenge by the researchers, due to the complex structure of the eye and its protective physiological mechanisms. In addition, the low viscosity of the eye drops and the resulting short ocular residence time further contribute to the observed low drug concentration at the target site. Therefore, various drug delivery platforms are being developed to enhance ocular bioavailability, provide controlled and sustained drug release, reduce the number of applications, and maximize therapy outcomes. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) exhibit all these benefits, in addition to being biocompatible, biodegradable, and susceptible to sterilization and scale-up. Furthermore, their successive surface modification contributes to prolonged ocular residence time (by adding cationic compounds), enhanced penetration, and improved performance. The review highlights the salient characteristics of SLNs and NLCs concerning ocular drug delivery, and updates the research progress in this area.
Apelin Is a Prototype of Novel Drugs for the Treatment of Acute Myocardial Infarction and Adverse Myocardial Remodeling
Authors: Popov Sergey V. , Maslov Leonid N. , Mukhomedzyanov Alexandr V. , Kurbatov Boris K. , Gorbunov Alexandr S. , Kilin Michail , Azev Viacheslav N. , Khlestkina Maria S. , Sufianova Galina Z.
Published: March 2023

In-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI) is 5–6%. Consequently, it is necessary to develop fundamentally novel drugs capable of reducing mortality in patients with acute myocardial infarction. Apelins could be the prototype for such drugs. Chronic administration of apelins mitigates adverse myocardial remodeling in animals with myocardial infarction or pressure overload. The cardioprotective effect of apelins is accompanied by blockage of the MPT pore, GSK-3β, and the activation of PI3-kinase, Akt, ERK1/2, NO-synthase, superoxide dismutase, glutathione peroxidase, matrix metalloproteinase, the epidermal growth factor receptor, Src kinase, the mitoKATP channel, guanylyl cyclase, phospholipase C, protein kinase C, the Na+/H+ exchanger, and the Na+/Ca2+ exchanger. The cardioprotective effect of apelins is associated with the inhibition of apoptosis and ferroptosis. Apelins stimulate the autophagy of cardiomyocytes. Synthetic apelin analogues are prospective compounds for the development of novel cardioprotective drugs.
Allelopathic Activity of Canadian Goldenrod (Solidago canadensis L.) Extracts on Seed Germination and Growth of Lettuce (Lactuca sativa L.) and Garden Pepper Cress (Lepidium sativum L.)
Authors: Judžentienė Asta , Būdienė Jurga , Labanauskas Linas , Stancelytė Donata , Nedveckytė Irena
Published: March 2023

Native to N. America, Canadian goldenrod (Solidago canadensis L.) was introduced to Europe as an ornamental plant and quickly spread here and in other parts of the world. The rapid spread of the plant is due to several reasons: phenotypic plasticity, broad climatic tolerance, propagation via underground rhizomes and seeds that mature in large numbers, etc. Additionally, the success of Canadian goldenrod’s invasion is determined by its allelochemicals that affect seed germination, root formation and whole growth of nearby plants. Allelopathy of various extracts and essential oils (EOs) of S. canadensis on seed germination and growth of lettuce (Lactuca sativa L.) and garden pepper cress (Lepidium sativum L.) was evaluated and compared with other Solidago species (S. virgaurea, S. × niederederi) collected from the same growing locality in Lithuania. Soil characteristics (conductivity, pH and major elements) of the collecting site were determined. Aqueous flower extracts of all studied Solidago species showed the highest inhibitory effect on model plants. Canadian goldenrod leaf water/diethyl ether extract showed highest inhibitory effect in all relative concentrations (1.0; 0.1; 0.01) suppressing growth of L. sativa (from 0 to 2.3 mm compared with 22.7 mm for control samples) and L. sativum (from 0.5 to 16.8 mm compared with 35.3 mm in control). It was noticed that garden pepper cress was more susceptible to Solidago spp. inhibitory effects than lettuce. S. canadensis root EOs comprised mainly of limonene (35.0%) and β-pinene (26.2%) and inflorescence oils containing α-pinene (21.6%), germacrene D (15.1%), limonene (10.2%) and lupenyl acetate (9.8%) exhibited the highest inhibitory effect on lettuce and garden pepper cress growth. Relative germination and vigor index of model plants was conducted. Chemical composition of extracts and EOs was determined by HPLC/DAD/TOF and GC/MS techniques.
Tailor-Made Bio-Based Non-Isocyanate Polyurethanes (NIPUs)
Authors: Catalá Juan , Guerra Irene , García-Vargas Jesús Manuel , Ramos María Jesús , García María Teresa , Rodríguez Juan Francisco
Published: March 2023

Non-isocyanate polyurethanes (NIPUs) based on biobased polyamines and polycarbonates are a sustainable alternative to conventional polyurethanes (PU). This article discloses a novel method to control the crosslinking density of fully biobased isocyanate-free polyurethanes, synthesized from triglycerides carbonated previously in scCO2 and different diamines, such as ethylenediamine (EDA), hexamethylenediamine (HMDA) and PriamineTM-1075 (derived from a dimerized fatty acid). As capping substances, water or bioalcohols are used in such a way that the crosslinking density can be adjusted to suit the requirements of the intended application. An optimization of the NIPU synthesis procedure is firstly carried out, establishing the polymerization kinetics and proposing optimal conditions set for the synthesis of the NIPUs. Then, the influence of the partial blocking of the active polymerization sites of the carbonated soybean oil (CSBO), using monofunctional amines, on the physical properties of the NIPUS is explored. Finally, the synthesis of fully biobased NIPUs with a targeted crosslinking density is achieved using hybrid NIPUs, employing partially carbonated oil and H2O or ethanol as blockers to achieve the desired physical properties in a very precise manner.
Inversion of Upstream Solar Wind Parameters from ENA Observations at Mars
Authors: Zhang Yiteng , Li Lei , Xie Lianghai , Kong Linggao , Li Wenya , Tang Binbin , Ma Jijie , Zhang Aibing
Published: March 2023

An algorithm has been developed to invert the solar wind parameters from the hydrogen energetic neutral atom (H-ENA) measured in near-Mars space. Supposing the H-ENA is produced by change exchange collision between protons that originated in the solar wind and neutrals in the exosphere, an H-ENA model is established based on the magnetohydrodynamic (MHD) simulation of the solar wind interaction with Mars, to study the H-ENA characteristics. It is revealed that the solar wind H-ENAs are high-speed, low-temperature beams, just like the solar wind, while the magnetosheath H-ENAs are slower and hotter, with broader energy distribution. Assuming Maxwellian velocity distribution, the solar wind H-ENA flux is best fitted by a Gaussian function, from which the solar wind velocity, density, and temperature can be retrieved. Further investigation, based on the ENA flux simulated by the H-ENA model, reveals that the accuracy of inversed solar wind parameters is related to the angular and energy resolutions of the ENA detector. Finally, the algorithm is verified using the H-ENA observations from the Tianwen-1 mission. The upstream solar wind velocity when inversed is close to that of the in situ plasma measurement. Our result suggests the solar wind parameters inversed from H-ENA observation could be an important supplement to the dataset supporting studies on the Martian space environment, where long-term continuous monitoring of the upstream SW condition is lacking.
Vegetation Cover Variation in Dry Valleys of Southwest China: The Role of Precipitation
Authors: Guo Qiankun , Zhong Ronghua , Shan Zhijie , Duan Xingwu
Published: March 2023

Many ecological restoration projects have been carried out in Southwest China; however, changes in vegetation cover in the dry valleys of Southwest China have rarely been reported. With their unique characteristics of high temperatures and low humidity, these dry valleys have considerably lower vegetation cover than their neighboring areas, making them the main sediment sources of rivers in Southwest China. Thus, it is imperative to understand changes in vegetation cover in China’s dry valleys, as well as the effects of changes in precipitation, since water deficit is the dominant cause of obstructed plant growth. In this study, changes in fractional vegetation cover (FVC) in dry valleys in the period 2000 to 2020 were analyzed based on MODIS-NDVI data, and the effects of precipitation were also analyzed. Our results indicated that: (1) the long-term mean annual FVC values in the dry–hot valleys (DHVs), dry–warm valleys (DWVs), and dry–temperate valleys (DTVs) were 0.426, 0.504, and 0.446, respectively; (2) significant decreasing trends in FVC were mainly found in DHVs and DWVs that were distributed in the southwestern part of the dry valley region (DVR), which was mainly due to the decrease in precipitation; and (3) significant increasing trends were reported in DTVs of the Min River and the Baishui River, which was probably due to the increase in precipitation. By analyzing the temporal trends of FVC in dry valleys, this study highlighted the effects of precipitation on the dynamics of FVC and demonstrated that anthropogenic activities such as urbanization, land use changes, and hydro-power project construction may also have considerable effects on FVC in dry valleys. Overall, this study not only provides insights that might inform further detailed studies on the dynamics and mechanisms of vegetation cover, but could also provide valuable guidance for ecological restoration management in the dry valley region.
Direction of Arrival Method for L-Shaped Array with RF Switch: An Embedded Implementation Perspective
Authors: Troccoli Tiago , Pirskanen Juho , Nurmi Jari , Ometov Aleksandr , Morte Jorge , Lohan Elena Simona , Kaseva Ville
Published: March 2023

This paper addresses the challenge of implementing Direction of Arrival (DOA) methods for indoor localization using Internet of Things (IoT) devices, particularly with the recent direction-finding capability of Bluetooth. DOA methods are complex numerical methods that require significant computational resources and can quickly deplete the batteries of small embedded systems typically found in IoT networks. To address this challenge, the paper presents a novel Unitary R-D Root MUSIC for L-shaped arrays that is tailor-made for such devices utilizing a switching protocol defined by Bluetooth. The solution exploits the radio communication system design to speed up execution, and its root-finding method circumvents complex arithmetic despite being used for complex polynomials. The paper carries out experiments on energy consumption, memory footprint, accuracy, and execution time in a commercial constrained embedded IoT device series without operating systems and software layers to prove the viability of the implemented solution. The results demonstrate that the solution achieves good accuracy and attains an execution time of a few milliseconds, making it a viable solution for DOA implementation in IoT devices.
YOLOv5s-CA: A Modified YOLOv5s Network with Coordinate Attention for Underwater Target Detection
Authors: Wen Ge , Li Shaobao , Liu Fucai , Luo Xiaoyuan , Er Meng-Joo , Mahmud Mufti , Wu Tao
Published: March 2023

Underwater target detection techniques have been extensively applied to underwater vehicles for marine surveillance, aquaculture, and rescue applications. However, due to complex underwater environments and insufficient training samples, the existing underwater target recognition algorithm accuracy is still unsatisfactory. A long-term effort is essential to improving underwater target detection accuracy. To achieve this goal, in this work, we propose a modified YOLOv5s network, called YOLOv5s-CA network, by embedding a Coordinate Attention (CA) module and a Squeeze-and-Excitation (SE) module, aiming to concentrate more computing power on the target to improve detection accuracy. Based on the existing YOLOv5s network, the number of bottlenecks in the first C3 module was increased from one to three to improve the performance of shallow feature extraction. The CA module was embedded into the C3 modules to improve the attention power focused on the target. The SE layer was added to the output of the C3 modules to strengthen model attention. Experiments on the data of the 2019 China Underwater Robot Competition were conducted, and the results demonstrate that the mean Average Precision (mAP) of the modified YOLOv5s network was increased by 2.4%.
Electrochemical and Optical Sensors for the Detection of Chemical Carcinogens Causing Leukemia
Authors: Kowalczyk Adrian , Zarychta Julia , Lejman Monika , Zawitkowska Joanna
Published: March 2023

The incidence and mortality due to neoplastic diseases have shown an increasing tendency over the years. Based on GLOBOCAN 2020 published by the International Agency for Research on Cancer (IARC), leukemias are the thirteenth most commonly diagnosed cancer in the world, with 78.6% of leukemia cases diagnosed in countries with a very high or high Human Development Index (HDI). Carcinogenesis is a complex process initiated by a mutation in DNA that may be caused by chemical carcinogens present in polluted environments and human diet. The IARC has identified 122 human carcinogens, e.g., benzene, formaldehyde, pentachlorophenol, and 93 probable human carcinogens, e.g., styrene, diazinone. The aim of the following review is to present the chemical carcinogens involved or likely to be involved in the pathogenesis of leukemia and to summarize the latest reports on the possibility of detecting these compounds in the environment or food with the use of electrochemical sensors.