bluuebunny/crossref_metadata_2025 huggingface dataset:
A 3D complexity-adaptive approach to explore sparsity in elastic wave propagation
Authors: Haindl Claudia , Leng Kuangdai , Nissen-Meyer Tarje
Published: May 2021

We have developed an adaptive approach for seismic modeling by which the computational cost of a 3D simulation can be reduced while retaining the resolution and accuracy. This azimuthal complexity adaptation (ACA) approach relies upon the inherent smoothness of wavefields around the azimuth of a source-centered cylindrical coordinate system. Azimuthal oversampling is thereby detected and eliminated. The ACA method has recently been introduced as part of AxiSEM3D, an open-source solver for global seismology. We use a generalization of this solver that can handle local-scale Cartesian models and that features a combination of an absorbing boundary condition and a sponge boundary with automated parameter tuning. The ACA method is benchmarked against an established 3D method using a model featuring bathymetry and a salt body. We obtain a close fit when the models are implemented equally in both solvers and an expectedly poor fit otherwise, with the ACA method running an order of magnitude faster than the classic 3D method. Furthermore, we evaluate maps of maximum azimuthal wavenumbers that are created to facilitate ACA. We determine how these maps can be interpreted in terms of the 3D complexity of the wavefield and in terms of seismic resolution. The expected performance limits of the ACA method for complex 3D structures are tested on the SEG/EAGE salt model. In this case, ACA still reduces the overall degrees of freedom by 92% compared with a complexity-blind AxiSEM3D simulation. In comparison to the reference 3D method, we again find a close fit and a speedup of a factor of 7. We explore how the performance of ACA is affected by model smoothness by subjecting the SEG/EAGE salt model to Gaussian smoothing. This results in a doubling of the speedup. Thus, ACA represents a convergent, versatile, and efficient method for a variety of complex settings and scales.
Joint wave-equation traveltime inversion of diving/direct and reflected waves for P- and S-wave velocity macromodel building
Authors: Ren Zhiming , Bao Qianzong , Gu Bingluo
Published: May 2021

Full-waveform inversion (FWI) suffers from the local minima problem and requires a sufficiently accurate starting model to converge to the correct solution. Wave-equation traveltime inversion (WETI) is an effective tool to retrieve the long-wavelength components of the velocity model. We have developed a joint diving/direct and reflected wave WETI (JDRWETI) method to build P- and S-wave velocity macromodels. We estimate the traveltime shifts of seismic events (diving/direct waves and PP- and PS-reflections) through the dynamic warping scheme and construct a misfit function using the time shifts of diving/direct and reflected waves. We derive the adjoint wave equations and the gradients with respect to the background models based on the joint misfit function. We apply the kernel decomposition scheme to extract the kernel of the diving/direct wave and the tomography kernels of PP- and PS-reflections. For an explosive source, the kernels of the diving/direct wave and PP-reflections and the kernel of the PS-reflections are used to compute the P- and S-wave gradients of the background models, respectively. We implement JDRWETI by a two-stage inversion workflow: First, we invert the P- and S-wave velocity models using the P-wave gradients, and then we improve the S-wave velocity model using the S-wave gradients. Numerical tests on synthetic and field data sets reveal that the JDRWETI method successfully recovers the long-wavelength components of P- and S-wave velocity models, which can be used for an initial model for the subsequent elastic FWI. Moreover, the JDRWETI method prevails over the existing reflection WETI method and the cascaded diving/direct and reflected wave WETI method, especially when large velocity errors are present in the shallow part of the starting models. The JDRWETI method with the two-stage inversion workflow can give rise to reasonable inversion results even for the model with different P- and S-wave velocity structures.
Depth to magnetic basement in the Anambra Basin, Benue Trough of Nigeria from aeromagnetic data: A prelude for hydrocarbon exploration
Authors: Olagundoye Olatunbosun O. , Okereke Chiedu S. , Edet Aniekan E. , Obi Dominic , Ukpong Aniediobong
Published: May 2021

Data transformation, regional-residual separation, trend analysis, and analytic signal (AS) depth estimation were applied to aeromagnetic data covering the Anambra Basin, which is a major depocenter in the Benue Trough, southeast Nigeria, with the primary objectives of accentuating the attributes of magnetic sources and determining if sufficient sediment thickness exists for hydrocarbon generation, maturation, and expulsion. The application of data transformation techniques (such as map projection, merging, and reduction-to-pole) and regional-residual ensured the computation of a crustal magnetic field that would be suitable for magnetic analyses. Results indicate that the magnetic basement in the basin forms an undulating surface overlain by sediments with an average thickness ranging between 4 and 7.5 km, whereas the maximum thickness reaches 8 km in some areas. This depth range suggests a promising prospect for source-facies maturation and expulsion. We expect that areas in the study area with these appreciable sediment thicknesses, good preservation of graben fill, and suitable areal closures or fault structures would be favorable for hydrocarbon prospectivity.
The Impact of the COVID-19 Pandemic on Self-Reported Outcomes in Patients With Adrenal Insufficiency
Authors: Li Dingfeng , Suresh Malavika , Abbondanza Tiffany , Vaidya Anand , Bancos Irina
Published: May 2021

Context

The COVID-19 pandemic has impacted healthcare environment.

Objective

To determine the impact of the pandemic on self-reported outcomes in patients with adrenal insufficiency (AI).

Design and setting

Prospective longitudinal survey study at 2 tertiary centers.

Participants

Patients with AI.

Intervention

Patient-centered questionnaire.

Main outcome measures

Depression Anxiety Stress Scales-21, Short Form-36, and AI self-management.

Results

Of 342 patients, 157 (46%) had primary AI, 109 (32%) had secondary AI, and 76 (22%) had glucocorticoid-induced AI. When compared to prepandemic, daily glucocorticoid dose and number of adrenal crises did not change. However, patients reported a higher financial impact from AI (34% vs 23%, P = 0.006) and difficulty accessing medical care (31% vs 7%, P < 0.0001) during the pandemic. A third of patients reported difficulty managing AI during the pandemic. After adjusting for duration and subtypes of AI, younger patients [odds ratio (OR) 2.3, CI 95% 1.3-4.1], women (OR 3.7, CI 95% 1.9-7.1), poor healthcare access(OR 4.2, CI 95% 2.3-7.7), lack of good insurance support (OR 2.8, CI 95% 1.3-5.9), and those with a higher financial impact (OR 2.3, CI 95% 1.3-4.3) reported greater difficulties managing AI. Patients were more likely to report a higher anxiety score (≥8) if they found managing AI challenging during the pandemic (OR 3.0, CI 95% 1.3-6.9), and had lower Physical Component Summary (OR 4.9, CI 95% 2.2-11.0) and Mental Component Summary (OR 4.1, CI 95% 1.8-9.5) scores prior to the pandemic.

Conclusions

A third of patients with AI reported difficulties with management of AI during the pandemic, particularly in younger patients, women, and those with poor healthcare access.
Cranial Neuralgias
Authors: Robertson Carrie
Published: May 2021

PURPOSE OF REVIEW

This article discusses the differential diagnosis, evaluation, and management of trigeminal neuralgia and reviews other neuralgias of the head and neck, including those that contribute to neuralgic ear pain.

RECENT FINDINGS

Most cases of trigeminal neuralgia are related to vascular compression, a demyelinating plaque, or a compressive mass affecting the trigeminal nerve. However, recent studies have shown that up to 11% of patients have a family history of trigeminal neuralgia, suggesting that some patients may have a genetic predisposition to demyelination or nerve hyperexcitability. In these patients, trigeminal neuralgia may occur at a younger age, on both sides of the face, or in combination with other neuralgias.

When a patient presents with neuralgic pain, the diagnosis is made by careful history and neurologic examination, with attention to the dermatome involved, the triggers, and the presence of any associated sensory deficit. All patients with new neuralgia or neuropathic facial pain warrant a careful evaluation for a secondary cause. The presence of sensory deficit on bedside examination is particularly concerning for an underlying secondary etiology.
Spontaneous Intracranial Hypotension
Authors: Wang Shuu-Jiun
Published: May 2021

PURPOSE OF REVIEW

Spontaneous intracranial hypotension is a disorder caused by spinal CSF leakage. This article reviews the clinical presentation, diagnosis, and treatment of spontaneous intracranial hypotension.

RECENT FINDINGS

The hallmark symptom of spontaneous intracranial hypotension is acute orthostatic headache; however, clinical presentations can be heterogeneous. New evidence shows that lumbar puncture is not always necessary or sufficient to establish the diagnosis. Some patients may have normal opening pressure, which suggests that insufficiency of CSF volume (hypovolemia) rather than CSF pressure might be the underlying mechanism. Several neuroimaging modalities can aid in diagnosis and localization of the CSF leakage, including brain MRI, spinal MRI, CT myelography, digital subtraction myelography, and radionuclide cisternography. Complications, such as subdural hematoma, can lead to a change in the headache pattern and potentially life-threatening consequences. Conservative treatments, such as fluid supplementation, can provide temporary relief; however, epidural blood patches, especially targeted ones, are more effective and definitive. For patients with refractory spontaneous intracranial hypotension, surgical repair of spinal CSF leakages should be considered.

Brain and spinal MRIs are important for the diagnosis and treatment of patients with spontaneous intracranial hypotension. Early treatment with epidural blood patches may be considered to shorten the disease duration and minimize the potential risk of complications.
Endogenous Education and Long-Run Factor Shares
Authors: Grossman Gene M. , Helpman Elhanan , Oberfield Ezra , Sampson Thomas
Published: May 2021

We study the determinants of factor shares in a neoclassical environment with capital-skill complementarity and endogenous education. In this environment estimates of the elasticity of substitution between capital and labor that fail to account for human capital levels will be biased upward. We develop a model with overlapping generations, technology-driven neoclassical growth, and ongoing increases in educational attainment. For a class of production functions featuring capital-skill complementarity, a balanced growth path exists and is characterized by an inverse relationship between the rates of capital-and labor-augmenting technological progress and the capital share in national income. (JEL D33, E25, J24, O33)
Diagnostic radiology findings and spectrum of therapeutic interventions in gynaecological and urogenital vascular anomalies
Authors: Grill Nadja , Struebing Felix , Krebs Lena , Sadick Maliha
Published: May 2021

Vascular anomalies represent a rare congenital disease with manifestation at diverse anatomical sights and presenting with heterogenous symptoms. Undetected, they can progress and create acute and chronic complications with functional impairment. The manifestation in the female and male pelvis and the urogenital tract represents a multidisciplinary challenge for physicians. Especially outpatient management in gynaecology and urology is affected. Diagnostic Radiology holds an important supportive role in early diagnosis of the underlying urogenital vascular anomaly and referral to interventional radiology, either for minimal invasive treatment, or to surgery for further assessment. This pictorial review creates awareness for the spectrum of vascular anomalies of the gynaecological and urogenital tract, their characteristic imaging findings and dedicated interventional treatment options. The individual description of vascular anomalies, based on an appropriate nomenclature and classification standard, is a guide for radiologists to distinguish the underlying vascular anomaly from other vascular disorders and to accelerate diagnosis as well as therapeutic proceedings. In consequence, interdisciplinary management of patients with vascular anomalies of the female and male pelvis will benefit.
Ein Blick unter das Pflaster des Münsterplatzes
Authors: Alder Cornelia , Bargetzi Dagmar , Flück Hannes , Schön Udo
Published: May 2021

Bei den archäologischen Untersuchungen im Zusammenhang mit dem Bau einer unterirdischen Transformatorenstation auf dem Münsterplatz konnte auf einer kleinen Fläche eine Fülle an Befunden und Funden von der frühen römischen Kaiserzeit bis ins Spätmittelalter ausgegraben werden.
Vom mittelalterlichen Kloster zum modernen Konzertgebäude
Authors: Bernasconi Marco , Graber Simon
Published: May 2021

Im Oktober 2016 begannen im Musiksaal des Basler Stadtcasinos umfangreiche Rettungsgrabungen. Unter dem Boden des Musiksaals eröffneten sich einmalige Einblicke in die wechselvolle Stadtgeschichte: Die kontinuierliche Entwicklung dieses Ortes beginnt vor knapp 1000 Jahren mit dem Bau der ersten Stadtmauer und dem Bau der zweiten Stadtmauer um 1250 und erstreckt sich über die Klosterbauten der Barfüssermönche, den nachreformatorischen Friedhof und das «Irrenhaus» bis zum Kaufhaus aus dem 19. Jahrhundert und schliesslich dem Musiksaal von 1876. Der Musiksaal steht damit an einem für die Stadtentwicklung von Basel exemplarischen Ort, der eindrücklich von der Entwicklung eines peripheren Areals ausserhalb der mittelalterlichen Stadt zu einer Kulturmeile im heutigen Stadtzentrum erzählt.
Géneros textuales mercantiles en la traducción jurídico-económica (alemán-español)
Authors: Cobos López Ingrid
Published: May 2021

El Derecho Mercantil es una rama del Derecho que pertenece tanto al ámbito jurídico de la traducción, como al económico. Basándonos en las teorías de los géneros textuales y en la legislación vigente, trataremos de delimitar este subgénero textual y proponer una clasificación propia de los textos que se crean dentro de este ámbito jurídico-comercial y, además, profundizar en los textos que se producen en la constitución de una sociedad mercantil en el par de lenguas alemán-español. Para ello, realizaremos nuestra propuesta y presentaremos algunos de los textos que más se traducen en este par de lenguas.
La Teoría de la Recepción en torno a la obra artística y su aplicación meta-teórica a través del análisis musical
Authors: García Blanco Celso M.
Published: May 2021

as obras musicales pueden analizarse desde múltiples perspectivas, una de ellas desde la recepción, es decir, estudiando la impresión que causa en aquellos que la escuchan. En este estudio nos proponemos aplicar la “teoría de la recepción” en torno a la obra artística específicamente al análisis musical a través de diferentes factores, entre los que destacan: la producción-recepción, su relación con los materiales primigenios, el horizonte de expectativas, los prejuicios o juicios previos, el paso del tiempo y el contexto socio-histórico y económico en el que la pieza musical fue creada y en el que está inserta, por mencionar algunos de los principales. Así, este trabajo primero bebe de otras materias, como la Sociología, la Lingüística o la Literatura, para llegar a la puesta en marcha de un enfoque de corte interdisciplinar adaptado a los principios musicales.
The Earnings Expectations Game and the Dispersion Anomaly
Authors: Veenman David , Verwijmeren Patrick
Published: May 2021

This study examines the role of differences in firms’ propensity to meet earnings expectations in explaining why firms with high analyst forecast dispersion experience relatively low future stock returns. We first demonstrate that the negative relation between dispersion and returns is concentrated around earnings announcements. Next, we show that this relation disappears when we control for ex ante measures of firms’ propensity to meet earnings expectations and that the component of dispersion explained by these measures drives the return predictability of dispersion. We further demonstrate that firms with low analyst dispersion are substantially more likely to achieve positive earnings surprises and provide new evidence consistent with both expectations management and strategic forecast pessimism explaining this result. Overall, we conclude that investor mispricing of firms’ participation in the earnings-expectations game provides a viable explanation for the dispersion anomaly.

This paper was accepted by Brian Bushee, accounting.
Turn Your Online Weight Management from Zero to Hero: A Multidimensional, Continuous-Time Evaluation
Authors: Zhou Tongxin , Yan Lu (Lucy) , Wang Yingfei , Tan Yong
Published: May 2021

Online weight-loss communities (OWCs) provide individuals with various tools to support their weight management, such as weight recorders and weight-loss journals. These tools enable individuals to focus on different aspects of their self-regulation, including weight-loss outcomes and behavioral routines. Prior research, however, has not fully incorporated individuals’ self-regulation focuses; thus, there is limited understanding of individuals’ online weight-management dynamics as well as the operating mechanisms of OWCs. This gap in the literature motivates us to develop a framework that is able to account for individuals’ multiple self-regulation focuses, termed self-regulatory dimensions in this study. We propose a multidimensional, continuous-time hidden Markov model, which can not only capture individuals’ self-regulatory dimensions jointly as a multidimensional vector, but also can incorporate a hidden layer of dynamics that depicts individuals’ cognitive states in producing weight-management behaviors. By investigating a leading noncommercial OWC in the United States, we find that individuals tend to increase their journal-recording behaviors while decreasing self-weighing behaviors after they have participated in online social activities. Given that individuals usually expend limited effort toward weight management, this result suggests that individuals may shift their focus from weight-loss outcomes (i.e., changes in weight) to weight-management behavioral routines. Therefore, neglecting either self-regulatory dimension would result in an underestimation of individuals’ engagement in conducting self-management in OWCs. Our results also provide insight into social influence on individuals’ weight-management behaviors. This study contributes to the extant literature on individuals’ engagement in online healthcare communities and the functionality of OWCs.

This paper was accepted by Anandhi Bharadwaj, information systems.
Functional electrical stimulation as a promising intervention for polymyositis-related weakness: a case report
Authors: Morgan Marie Vazquez , Tinsley Suzanne , Henderson Rachael
Published: May 2021

Background/aims

Polymyositis is an inflammatory myopathy characterised by chronic and progressive muscle weakness. This case report discusses a 61-year-old African-American man with polymyositis. Even though pharmacological and physical therapy interventions had previously been prescribed, they had not been beneficial. This case report examined the effects of a functional electric stimulation-assisted exercise programme.

Methods

The patient was treated in an outpatient clinic two times a week and performed exercises three times a week on alternating days for 36 weeks. In the clinic, he received functional electrical stimulation-assisted strengthening to quadriceps, hamstrings and gluteus maximus while performing activities such as sit to stand, squats, bridging and cycling. For endurance training, he ambulated on the clinic track with a neuroprosthetic to assist with dorsiflexion in the swing phase of gait. At home, he performed lower extremity and core strengthening exercises. Measures to evaluate the intervention included the Manual Muscle Test, functional mobility (Timed Up and Go Test), balance (Berg Balance Scale, Activities of Balance Confidence Scale), endurance (Six-Minute Walk Test with a modified Borg scale) and gait speed (10-Metre Walk Test).

Results

After 36 weeks of treatment, the patient had made gains in strength in all muscle groups in his bilateral lower extremities except hip extensors. Timed Up and Go time decreased by 14.01 seconds. The patient changed from a medium fall risk to low fall risk on the Berg Balance Scale and his confidence increased by 46.2% on the Activities of Balance Confidence Scale. Furthermore, he gained endurance as exhibited by his increased distance of 289 feet on the Six-Minute Walk Test and his modified Borg score decreased from 4 out of 10 to 2 out of 10. The patient made subjective and objective gains in gait speed, increasing from 0.18 metres per second at his initial examination to 0.50 metres per second.

Conclusions

This case study demonstrates that functional electrical stimulation-assisted exercise, conducted in an outpatient setting, can improve strength and functional mobility in an individual with polymyositis without detrimental effects.
Impact of inspiratory muscle training on diaphragmatic mobility and arterial blood gases in patients undergoing haemodialysis
Authors: Aboelmagd Fatma , Ismail Samah M
Published: May 2021

Background/aims

Impairment of respiratory muscle function is common in patients with chronic kidney disease undergoing haemodialysis, and is manifested by decreased oxygenation and physical function. The purpose of this study was to analyse the impact of training with incentive spirometer on mobility of the diaphragm, arterial blood gases and functional capacity in patients with chronic kidney disease undergoing haemodialysis.

Methods

A pre–post research design was implemented. A total of 30 patients undergoing haemodialysis for chronic kidney disease received incentive spirometer training intradialysis three sessions a week for 8 weeks. Outcome measures were the amount of diaphragmatic mobility measured by ultrasonography, the levels of arterial partial pressure of oxygen, arterial partial pressure of carbon dioxide, oxygen saturation percentages and the distance walked in 6 minutes.

Results

Significant improvement from pre-treatment to post-treatment measurements occurred in all outcome measures, with P<0.05.

Conclusions

Incentive spirometer training should be recommended to be a part of daily routine of patients with chronic kidney disease who are undergoing haemodialysis to decrease respiratory and physical function impairments.
Profound downregulation of neural transcription factor Npas4 and Nr4a family in fetal mice neurons infected with Zika virus
Authors: Alpuche-Lazcano Sergio P. , Saliba James , Costa Vivian V. , Campolina-Silva Gabriel H. , Marim Fernanda M. , Ribeiro Lucas S. , Blank Volker , Mouland Andrew J. , Teixeira Mauro M. , Gatignol Anne
Published: May 2021

Zika virus (ZIKV) infection of neurons leads to neurological complications and congenital malformations of the brain of neonates. To date, ZIKV mechanism of infection and pathogenesis is not entirely understood and different studies on gene regulation of ZIKV-infected cells have identified a dysregulation of inflammatory and stem cell maintenance pathways. MicroRNAs (miRNAs) are post-transcriptional regulators of cellular genes and they contribute to cell development in normal function and disease. Previous reports with integrative analyses of messenger RNAs (mRNAs) and miRNAs during ZIKV infection have not identified neurological pathway defects. We hypothesized that dysregulation of pathways involved in neurological functions will be identified by RNA profiling of ZIKV-infected fetal neurons. We therefore used microarrays to analyze gene expression levels following ZIKV infection of fetal murine neurons. We observed that the expression levels of transcription factors such as neural PAS domain protein 4 (Npas4) and of three members of the orphan nuclear receptor 4 (Nr4a) were severely decreased after viral infection. We confirmed that their downregulation was at both the mRNA level and at the protein level. The dysregulation of these transcription factors has been previously linked to aberrant neural functions and development. We next examined the miRNA expression profile in infected primary murine neurons by microarray and found that various miRNAs were dysregulated upon ZIKV infection. An integrative analysis of the differentially expressed miRNAs and mRNAs indicated that miR-7013-5p targets Nr4a3 gene. Using miRmimics, we corroborated that miR-7013-5p downregulates Nr4a3 mRNA and protein levels. Our data identify a profound dysregulation of neural transcription factors with an overexpression of miR-7013-5p that results in decreased Nr4a3 expression, likely a main contributor to ZIKV-induced neuronal dysfunction.
Retinal and cortical visual acuity in a common inbred albino mouse
Authors: Braha Michelle , Porciatti Vittorio , Chou Tsung-Han
Published: May 2021

While albino mice are widely used in research which includes the use of visually guided behavioral tests, information on their visual capability is scarce. We compared the spatial resolution (acuity) of albino mice (BALB/c) with that of pigmented mice (C57BL/6J). We used a high-throughput pattern electroretinogram (PERG) and pattern visual evoked potential (PVEP) method for objective assessment of retinal and cortical acuity, as well as optomotor head-tracking response/ reflex (OMR). We found that PERG, PVEP, and OMR acuities of C57BL/6J mice were all in the range of 0.5–0.6 cycles/degree (cyc/deg). BALB/c mice had PERG and PVEP acuities in the range of 0.1–0.2 cyc/deg but were unresponsive to OMR stimulus. Results indicate that retinal and cortical acuity can be reliably determined with electrophysiological methods in BALB/c mice, although PERG/PVEP acuities are lower than those of C57BL/6J mice. The reduced acuity of BALB/c mice appears to be primarily determined at retinal level.
Effects of two different emotion-inducing methods on the emotional memory of non-clinically depressed individuals
Authors: Lin Wuji , Lin Jingyuan , Cai Xiaoqing , Deng Jun , Gao Yuan , Mo Lei
Published: May 2021

In the study of emotional memory bias in depressed individuals, most previous studies have used emotional materials, but there were significant differences in the effects of different emotion-inducing methods on face memory. In the present study, two experiments were conducted to explore the effects of different emotion-inducing methods on memory between healthy participants and non-clinically depressed participants. The results from experiment 1 showed that when feedback was used as induction, the memory performance of the non-clinical depression group was significantly higher than that of the healthy group under the condition of negative feedback. Under positive and neutral feedback, there were no significant differences between the two groups. In experiment 2, when emotional materials were used as a mode of induction, no significantly difference in each emotional condition between the healthy and depressed groups was found. The results of the present study show that different methods of emotional induction have different effects on depressed participants. Compared with the emotion induced by the emotional material, the non-clinical depressed participants had a better memory effect induced by negative emotional events.
Association of SMAD4 loss with drug resistance in clinical cancer patients: A systematic meta-analysis
Authors: Xu Wei , Lee Sau Har , Qiu Fengjun , Zhou Li , Wang Xiaoling , Ye Tingjie , Hu Xudong
Published: May 2021

Background

Drug resistance frequently led to the failure of chemotherapy for malignant cancers, hence causing cancer relapse. Thus, understanding mechanism of drug resistance in cancer is vital to improve the treatment efficacy. Here, we aim to evaluate the association between SMAD4 expression and the drug resistance in cancers by performing a meta-analysis.

Method

Relevant studies detecting SMAD4 expression in cancer patients treated with chemo-drugs up till December 2020 were systematically searched in four common scientific databases using selected keywords. The pooled hazard ratio (HR) was the ratio of hazard rate between SMAD4neg population vs SMAD4pos population. The HRs and risk ratios (RRs) with 95% confidence intervals (CIs) were used to explore the association between SMAD4 expression losses with drug resistance in cancers.

Result

After an initial screening according to the inclusion and exclusion criteria, eleven studies were included in the meta-analysis. There were a total of 2092 patients from all the included studies in this analysis. Results obtained indicated that loss of SMAD4 expression was significantly correlated with drug resistance with pooled HRs (95% CI) of 1.23 (1.01–1.45), metastasis with pooled RRs (95% CI) of 1.10 (0.97–1.25) and recurrence with pooled RRs (95% CI) of 1.32 (1.06–1.64). In the subgroup analysis, cancer type, drug type, sample size and antibody brand did not affect the significance of association between loss of SMAD4 expression and drug resistance. In addition, there was no evidence of publication bias as suggested by Begg’s test.

Conclusion

Findings from our meta-analysis demonstrated that loss of SMAD4 expression was correlated with drug resistance, metastasis and recurrence. Therefore, SMAD4 expression could be potentially used as a molecular marker for cancer resistance.
A survey of mosquito-borne and insect-specific viruses in hospitals and livestock markets in western Kenya
Authors: Chiuya Tatenda , Masiga Daniel K. , Falzon Laura C. , Bastos Armanda D. S. , Fèvre Eric M. , Villinger Jandouwe
Published: May 2021

Aedes aegypti and Culex pipiens complex mosquitoes are prolific vectors of arboviruses that are a global threat to human and animal health. Increased globalization and ease of travel have facilitated the worldwide dissemination of these mosquitoes and the viruses they transmit. To assess disease risk, we determined the frequency of arboviruses in western Kenyan counties bordering an area of high arboviral activity. In addition to pathogenic viruses, insect-specific flaviviruses (ISFs), some of which are thought to impair the transmission of specific pathogenic arboviruses, were also evaluated. We trapped mosquitoes in the short and long rainy seasons in 2018 and 2019 at livestock markets and hospitals. Mosquitoes were screened for dengue, chikungunya and other human pathogenic arboviruses, ISFs, and their blood-meal sources as determined by high-resolution melting analysis of (RT-)PCR products. Of 6,848 mosquitoes collected, 89% were trapped during the long rainy season, with A. aegypti (59%) and Cx. pipiens sensu lato (40%) being the most abundant. Most blood-fed mosquitoes were Cx. pipiens s.l. with blood-meals from humans, chicken, and sparrow (Passer sp.). We did not detect dengue or chikungunya viruses. However, one Culex poicilipes female was positive for Sindbis virus, 30 pools of Ae. aegypti had cell fusing agent virus (CFAV; infection rate (IR) = 1.27%, 95% CI = 0.87%-1.78%); 11 pools of Ae. aegypti had Aedes flavivirus (AeFV; IR = 0.43%, 95% CI = 0.23%-0.74%); and seven pools of Cx. pipiens s.l. (IR = 0.23%, 95% CI = 0.1%-0.45%) and one pool of Culex annulioris had Culex flavivirus. Sindbis virus, which causes febrile illness in humans, can complicate the diagnosis and prognosis of patients with fever. The presence of Sindbis virus in a single mosquito from a population of mosquitoes with ISFs calls for further investigation into the role ISFs may play in blocking transmission of other arboviruses in this region.
Associations between residential greenness and self-reported heart disease in Sri Lankan men: A cross-sectional study
Authors: Silva J. Padmaka , Singh Ankur , Oldenburg Brian , Gunathunga Wasantha , Alagiyawanna A. M. A. A. P. , Mavoa Suzanne
Published: May 2021

Cardiovascular diseases (CVDs) are major contributors to morbidity and mortality in lower-middle-income countries (LMICs). Features of the natural environment, such as greenness, are a potential, modifiable determinant of CVD, yet there is a lack of evidence, particularly in LMICs. Our study investigated associations between residential greenness, measured using the Normalized Difference Vegetation Index (NDVI), and self-reported heart disease in 5268 Sri Lankan men aged 34 to 55 years. Multivariable logistic regression models were fitted to examine associations between mean NDVI within 100 m, 400 m, 800 m, 1600 m, and 2000 m of the residential address, adjusting for age, marital status, income, education, alcohol consumption, smoking and road length. Fully adjusted models showed that a 0.1 increase in mean NDVI was associated with lower odds of heart disease when using the 400 m (OR: 0.80; 95% CI: 0.64, 1.00), 800 m (OR: 0.85; 95% CI: 0.63, 1.14), and 2000 m (OR: 0.74; 95% CI: 0.48, 1.13) buffers. Further research in different contexts, and with improved outcome measures, is needed to confirm relationships between residential greenness and heart disease in rural areas and in LMICs.
Attentional processing of pain faces and other emotional faces in chronic pain–an eye-tracking study
Authors: Priebe Janosch A. , Horn-Hofmann Claudia , Wolf Daniel , Wolff Stefanie , Heesen Michael , Knippenberg-Bigge Katrin , Lang Philip , Lautenbacher Stefan
Published: May 2021

Altered attentional processing of pain-associated stimuli–which might take the form of either avoidance or enhanced vigilance–is thought to be implicated in the development and maintenance of chronic pain. In contrast to reaction time tasks like the dot probe, eye tracking allows for tracking the time course of visual attention and thus differentiating early and late attentional processes. Our study aimed at investigating visual attention to emotional faces in patients with chronic musculoskeletal pain (N = 20) and matched pain-free controls (N = 20). Emotional faces (pain, angry, happy) were presented in pairs with a neutral face for 2000 ms each. Three parameters were determined: First fixation probabilities, fixation durations (overall and divided in four 500 ms intervals) and a fixation bias score as the relative fixation duration of emotional faces compared to neutral faces. There were no group differences in any of the parameters. First fixation probabilities were lower for pain faces than for angry faces. Overall, we found longer fixation duration on emotional compared to neutral faces (‘emotionality bias’), which is in accord with previous research. However, significant longer fixation duration compared to the neutral face was detected only for happy and angry but not for pain faces. In addition, fixation durations as well as bias scores yielded evidence for vigilant-avoidant processing of pain faces in both groups. These results suggest that attentional bias towards pain-associated stimuli might not generally differentiate between healthy individuals and chronic pain patients. Exaggerated attentional bias in patients might occur only under specific circumstances, e.g., towards stimulus material specifically relating to the specific pain of the patients under study or under high emotional distress.
Nursing supervisors’ perspectives on student preparedness before clinical placements- a focus group study
Authors: Leonardsen Ann-Chatrin L. , Brynhildsen Siri E. , Hansen Mette T. , Grøndahl Vigdis A.
Published: May 2021

Clinical placements and supervision is an integral part of nursing education internationally. There are significant differences between students’ expectations of clinical learning and their fulfillment. Few studies have focused on supervisors’ perspectives on clinical placements. The objective of this study was to explore nursing supervisors’ perspectives on students’ preparedness for clinical placements.

Methods

The study was conducted in a county in Southeastern-Norway, with 317.000 inhabitants, and within one hospital and one university college catchment area. Focus group interviews were conducted in the periode August to December 2018. Data were analyzed using Hsieh and Shannon’s conventional content analysis.

Results

34 nursing supervisors participated, three intellectual disability nurses and 31 registered nurses, working in four different primary healthcare wards and four different hospital wards. Participants’ age ranged from 23 to 58 years, one male only. Through the analysis we derived the category ‘Shared responsibility for preparation’ with subcategories a) Individual initiative, and b) University college facilitation.

Conclusions

Findings indicate that there is a gap between nursing supervisors’ expectations and reality regarding students’ preparedness for clinical placements. Moreover, nursing supervisors did not seem to focus on their own role in student preparedness.
An evolutionary analysis of new energy and industry policy tools in China based on large-scale policy topic modeling
Authors: Wang Qiqing , Li Cunbin
Published: May 2021

This study investigates the evolution of provincial new energy policies and industries of China using a topic modeling approach. To this end, six out of 31 provinces in China are first selected as research samples, central and provincial new energy policies in the period of 2010 to 2019 are collected to establish a text corpus with 23, 674 documents. Then, the policy corpus is fed to two different topic models, one is the Latent Dirichlet Allocation for modeling static policy topics, another is the Dynamic Topic Model for extracting topics over time. Finally, the obtained topics are mapped into policy tools for comparisons. The dynamic policy topics are further analyzed with the panel data from provincial new energy industries. The results show that the provincial new energy policies moved to different tracks after about 2014 due to the regional conditions such as the economy and CO2 emission intensity. Underdeveloped provinces tend to use environment-oriented tools to regulate and control CO2 emissions, while developed regions employ the more balanced policy mix for improving new energy vehicles and other industries. Widespread hysteretic effects are revealed during the correlation analysis of the policy topics and new energy capacity.
Examination of the proximodistal patellar position in small dogs in relation to anatomical features of the distal femur and medial patellar luxation
Authors: Murakami Sawako , Shimada Masakazu , Harada Yasuji , Hara Yasushi
Published: May 2021

Objective

To determine the influence of anatomical features of the distal femur on the proximodistal patellar position and compare the proximodistal patellar position between dogs with and without medial patellar luxation (MPL).

Study design

Retrospective case series (n = 71).

Methods

Mediolateral-view radiographs of clinical cases of dogs weighing less than 15 kg were obtained. The stifle joint angle, patellar ligament length, patellar length, size of the femoral condyle, trochlear length, and trochlear angle were measured and included in multiple linear regression analyses to ascertain their effects on the proximodistal patellar position. Radiographs were divided into MPL and control groups. The effects of MPL on the proximodistal patellar position and morphological factors were also examined.

Results

The final model for the proximodistal patellar position revealed that the patella became distal as the ratio of the patellar ligament length to patellar length decreased, the trochlear angle relative to the femur increased, the trochlear length relative to the patellar length increased, or the trochlear length relative to the femoral condyle width decreased. The proximodistal patellar position in the MPL group was not significantly different from that in the control group despite the trend towards a distally positioned patella (p = 0.073). The MPL group showed a significantly shorter trochlea (p<0.001) and greater trochlear angle relative to the femur (p = 0.029) than the control group.

Conclusion

The proximodistal patellar position depends on multiple factors, and its determination based on PLL/PL alone may not be appropriate. Dogs with MPL did not have a proximally positioned patella compared with dogs without MPL. Although hindlimbs with MPL had a shorter trochlea than those without patellar luxation, this difference did not appear to be sufficient to displace the patellar position proximally in small dogs, possibly compensated by increased trochlear angle relative to the femur.
Cytotoxicity of Gymnopilus purpureosquamulosus extracts on hematologic malignant cells through activation of the SAPK/JNK signaling pathway
Authors: Dulay Rich Milton , Valdez Benigno C. , Li Yang , Chakrabarti Seemanti , Dhillon Braham , Kalaw Sofronio P. , Reyes Renato G. , Cabrera Esperanza C.
Published: May 2021

Treatment of hematologic malignancies is a formidable challenge for hematologists and there is an urgent need to identify safe and efficacious agents either via synthesis in the laboratory or isolation from natural products. Here, we report the cytotoxicity of extracts from mushroom Gymnopilus purpureosquamulosus Høil (G. pps) and describe its molecular mechanisms. Using leukemia, lymphoma and multiple myeloma cell lines, 28–35 ppm G. pps extract inhibited cell proliferation by ~46–79%, which correlates with activation of apoptosis as indicated by increase in annexin V-positive cells (~5–8-fold), production of reactive oxygen species (~2–3-fold), cells in sub G0/G1 phase (~3–13-fold), caspase 3 enzymatic activity (~1.6–2.9-fold), DNA fragmentation, PARP1 cleavage and down-regulation of prosurvival proteins. Mitochondrial membrane potential decreased and leakage of pro-apoptotic factors to cytoplasm was observed, consistent with the activation of intrinsic apoptosis. Western blot analysis showed activation of the ASK1-MEK-SAPK/JNK and ASK1-P38 MAPK pathways possibly due to changes in the cellular redox status as suggested by decreased protein levels of peroxiredoxin, thioredoxin and thioredoxin reductase. Moreover, antioxidant N-acetylcysteine alleviated the cytotoxicity of G. pps. Pharmacological inhibition of SAPK/JNK and P38 alleviated the G. pps-mediated cytotoxicity. The extract activated apoptosis in leukemia and lymphoma patient cell samples but not in mononuclear cells from healthy donors further supporting the therapeutic values of G. pps for hematologic malignancies.
Evaluation of an Aspergillus IgG/IgM lateral flow assay for serodiagnosis of fungal asthma in Uganda
Authors: Kwizera Richard , Bongomin Felix , Olum Ronald , Worodria William , Bwanga Freddie , Meya David B. , Kirenga Bruce J. , Gore Robin , Denning David W. , Fowler Stephen J.
Published: May 2021

Background

Diagnosis of fungal allergies in asthma remains problematic in low-and middle-income countries due to non-availability of point-of-care testing. In this study, we aimed to evaluate the performance of an Aspergillus immunochromatographic technology (ICT) IgG/M lateral flow device (LFD) for the serological diagnosis of allergic bronchopulmonary aspergillosis (ABPA) and severe asthma with fungal sensitisation (SAFS) among Ugandan adult asthmatics.

Methods

374 adult (aged ≥18years) asthmatics in the African Severe Asthma Program study, Ugandan site constituted the study population. ABPA and SAFS were diagnosed according to standard criteria. Asthmatics who did not meet the above criteria constituted a control group. The LFD tests were performed and read according to manufacturer’s instructions.

Results

ABPA was found in 12/374 (3.2%) and SAFS in 60/374 (16%) participants. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for the Aspergillus ICT for the diagnosis of ABPA were 0.0%, 96.4%, 0.0% and 96.7% respectively, and for SAFS 6.7%, 97.1%, 30.8% and 84.5% respectively. False positive and negative rates were 3.5% and 3.2% for ABPA and 2.4% and 14.9% for SAFS, respectively. Patients with a positive LFD significantly had higher median Aspergillus fumigatus-specific IgE levels compared to those with negative LFD (median: 0.06 kUA/l VS 0.03 kUA/L, P = 0.011).

Conclusion

The Aspergillus ICT IgG/M LFD had a poor diagnostic performance for the diagnosis of both ABPA and SAFS. Its greatest value may be in distinguishing chronic and allergic aspergillosis in Africa.
Plasma GDF-15 concentration is not elevated in open-angle glaucoma
Authors: Hubens Wouter H. G. , Kievit Mariëlle T. , Berendschot Tos T. J. M. , de Coo Irenaeus F. M. , Smeets Hubert J. M. , Webers Carroll A. B. , Gorgels Theo G. M. F.
Published: May 2021

Aim

Recently, the level of growth differentiation factor 15 (GDF-15) in blood, was proposed as biomarker to detect mitochondrial dysfunction. In the current study, we evaluate this biomarker in open-angle glaucoma (OAG), as there is increasing evidence that mitochondrial dysfunction plays a role in the pathophysiology of this disease.

Methods

Plasma GDF-15 concentrations were measured with ELISA in 200 OAG patients and 61 age-matched controls (cataract without glaucoma). The OAG patient group consisted of high tension glaucoma (HTG; n = 162) and normal tension glaucoma (NTG; n = 38). Groups were compared using the Kruskal-Wallis nonparametric test with Dunn’s multiple comparison post-hoc correction. GDF-15 concentration was corrected for confounders identified with forward linear regression models.

Results

Before correcting for confounders, median plasma GDF-15 levels was significantly lower in the combined OAG group (p = 0.04), but not when analysing HTG and NTG patients separately. Forward linear regression analysis showed that age, gender, smoking and systemic hypertension were significant confounders affecting GDF-15 levels. After correction for these confounders, GDF-15 levels in OAG patients were no longer significantly different from controls. Subgroup analysis of the glaucoma patients did not show a correlation between disease severity and plasma GDF-15, but did reveal that for NTG patients, intake of dietary supplements, which potentially improve mitochondrial function, correlated with lower plasma GDF-15.

Conclusion

The present study suggests that plasma GDF-15 is not suited as biomarker of mitochondrial dysfunction in OAG patients.