bluuebunny/crossref_metadata_2025 huggingface dataset:
Some Improvements on Relativistic Positioning Systems
Authors: Alfonso Màrius Josep Fullana i , Milán Diego Pascual Sáez , Córdoba Josep Vicent Arnau i , Colmenero Neus Puchades
Published: October 2018

We make some considerations about Relativistic Positioning Systems (RPS). Four satellites are needed to position a user. First of all we define the main concepts. Errors should be taken into account. Errors depend on the Jacobian transformation matrix. Its Jacobian is proportional to the tetrahedron volume whose vertexes are the four tips of the receiver-satellite unit vectors. If the four satellites are seen by the user on a circumference in the sky, then, the Jacobian and the tetrahedron volume vanish. The users we consider are spacecraft. Spacecraft to be positioned cannot be close to a null Jacobian satellites-user configuration. These regions have to be avoided choosing an appropriate set of four satellites which are not seen too close to the same circumference in the sky. Errors also increase as the user spacecraft separates from the emission satellite region, since the tetrahedron volume decreases.We propose a method to autonomously potion a user-spacecraft which can test our method. This positioning should be compared with those obtained by current methods. Finally, a proposal to position a user-spacecraft moving far from Earth, with suitable devices (autonomous), is presented.
The Triaxiality Role in the Spin-Orbit Dynamics of a Rigid Body
Authors: Cantero A. , Crespo F. , Ferrer S.
Published: October 2018

We study the roto-orbital dynamics of a uniform sphere and a triaxial body by means of a radial intermediary, which defines a 2-DOF Hamiltonian system. Our analysis is carried out by using variables referred to the total angular momentum. Its validity and applicability is assessed numerically by experiments comprising three different scenarios; analysis of the triaxiality, eccentricity and altitude. They show that there is a range of parameters and initial conditions for which the radial distance and the slow angles are estimated accurately, even after one orbital period. On the contrary, fast angles deteriorates as the triaxiality grows. We also include the study of the relative equilibria, finding constant radius solutions filling 4-D and lower dimensional tori. These families of relative equilibria include some of the classical ones reported in the literature and some new types. For a number of scenarios the relation between the triaxiality and the inclination connected with relative equilibria are given.
New and Modified Eccentric Indices of Octagonal Grid Om
n
Authors: Naeem M. , Siddiqui M. K. , Guirao J. L. G. , Gao W.
Published: October 2018

The eccentricity εu
of vertex u in a connected graph G, is the distance between u and a vertex farthermost from u. The aim of the present paper is to introduce new eccentricity based index and eccentricity based polynomial, namely modified augmented eccentric connectivity index and modified augmented eccentric connectivity polynomial respectively. As an application we compute these new indices for octagonal grid

O
n
m

$\begin{array}{}
\displaystyle
O_n^m
\end{array}$

and we compare the results obtained with the ones obtained by other indices like Ediz eccentric connectivity index, modified eccentric connectivity index and modified eccentric connectivity polynomial ECP(G, x).
Travelling waves and conservation laws of a (2+1)-dimensional coupling system with Korteweg-de Vries equation
Authors: Khalique Chaudry Masood , Mhlanga Isaiah Elvis
Published: October 2018

In this paper we study a (2+1)-dimensional coupling system with the Korteweg-de Vries equation, which is associated with non-semisimple matrix Lie algebras. Its Lax-pair and bi-Hamiltonian formulation were obtained and presented in the literature. We utilize Lie symmetry analysis along with the (G′/G)–expansion method to obtain travelling wave solutions of this system. Furthermore, conservation laws are constructed using the multiplier method.
Galerkin-Chebyshev Pseudo Spectral Method and a Split Step New Approach for a Class of Two dimensional Semi-linear Parabolic Equations of Second Order
Authors: Talay Akyildiz F. , Vajravelu K.
Published: October 2018

In this paper, we use a time splitting method with higher-order accuracy for the solutions (in space variables) of a class of two-dimensional semi-linear parabolic equations. Galerkin-Chebyshev pseudo spectral method is used for discretization of the spatial derivatives, and implicit Euler method is used for temporal discretization. In addition, we use this novel method to solve the well-known semi-linear Poisson-Boltzmann (PB) model equation and obtain solutions with higher-order accuracy. Furthermore, we compare the results obtained by our method for the semi-linear parabolic equation with the available analytical results in the literature for some special cases, and found excellent agreement. Furthermore, our new technique is also applicable for three-dimensional problems.
Reckoning of the Dissimilar Topological indices of Human Liver
Authors: Lokesha V. , Shruti R. , Deepika T.
Published: October 2018

The molecular topological indices as validly demonstrated its high performance in the discovery and design of new drugs. The goal of this paper is to study the structurally constructed a graph model of human Liver using graph operator. After the construction, nurtured the model using various topological indices. Also, established a diagnosis defect in the human Liver. Basically, considered structure of Liver can divide into healthy Liver and affected Liver. In this case study the topological indices are used in describe the structure of Liver using graph operator. Constructed model can be useful further in the medical field for any diagnosis with special care.
Acousto-optic modulation in ion implanted semiconductor plasmas having SDDC
Authors: Malviya P.S. , Yadav N. , Ghosh S.
Published: October 2018

The present paper is aimed to the exploration of acousto-optic (AO) modulational amplification in ion implanted semiconductors. The AO modulational process has been treated as a four wave parametric mixing process and the effective third-order acousto-optic susceptibility characterizing the instability process has been deduced. By considering that the origin of modulational interaction lies in the third order AO susceptibility arising from the nonlinear induced current density and using the coupled mode theory, an analytical investigation of an intense laser beam in a strain dependent dielectric constant (SDDC) semiconductor crystal is presented. We found a significant change in threshold and gain characteristics with changes in charge imbalance parameter. The presence of colloidal grains (CGs) plays an effective role in changing the threshold intensity and effective gain constant.
A finite difference method for a numerical solution of elliptic boundary value problems
Authors: Pandey P.K. , Jaboob S.S.A.
Published: October 2018

In this article, we have considered for numerical solution of a Poisson and Laplace equation in a domain. we have presented a novel finite difference method for solving the system of the boundary value problems subject to Dirichlet boundary conditions. We have derived the solution of the Poisson and Laplace equations in a two-dimensional finite region. We present numerical experiments to demonstrate the efficiency of the method.
Applications and props: the impact on engagement and understanding
Authors: Corner Alexander S , Cornock Claire
Published: October 2018

Problems based on applications or objects were added into a first year pure module in gaps where real-life problems were missing. Physical props were incorporated within the teaching sessions where it was possible. The additions to the module were the utilities problem whilst studying planar graphs, data storage when looking at number bases, RSA encryption after modular arithmetic and the Euclidean algorithm, as well as molecules and the mattress problem when looking at group theory. The physical objects used were tori, molecule models and mini mattresses. Evaluation was carried out through a questionnaire to gain the students' opinions of these additions and their general views of applications. Particular attention was paid to the effect on engagement and understanding.
Editorial
Authors: Owen Alun
Published: October 2018

Editorial.
Variantes de la cerámica proveniente del Sitio Arqueológico de Choquepujio.
Authors: Gonzales Sujay
Published: October 2018

Los trabajos realizados durante las excavaciones no arqueológicas, para el proyecto de Construcción del “Sistema de Agua Potable y Saneamiento en la Localidad de Nueva Huacarpay, del Distrito de Lucre”, Provincia de Quispicanchi, Departamento de Cusco, evidenciaron material alfarero, el cuál sirvió tras la clasificación y análisis se pudo identificar algunos características morfológicas permitiendo explicar los distintos comportamientos que posee la evidencia alfarera dentro de un mismo espacio y a su vez determinar los tipos de asentamientos culturales establecidos en el mismo entendiendo la posibilidad desuperposición de espacios, manufactura o intercambios culturales; siendo un limitante el tipo de excavaciones realizadas puesto que estas no eran excavaciones arqueológicas controladas bajo una técnica o metodología propia para la recuperación de material cultural. Es por tal razón que se realizó el análisis de los fragmentos de cerámica evidenciados en sus atributos morfológicos y decoración de los mismos, realizando un análisis comparativo de su composición con elementos hallados en la zona de Choquepujio en investigaciones previas. Los trabajos en gabinete, permitieron un análisis más detallado y contextual, en donde se determinó un espacio muestral de los fragmentos más representativos identificando básicamente la función de los mismos y sus posibles variantes, identificando que en su mayoría estos corresponden a un estilo Killke.
Importancia de las herramientas y entornos de aprendizaje dentro de la plataforma e-learning en las universidades del Ecuador
Authors: Verdezoto Rodríguez Raquel Herminia , Chávez Vaca Vinicio Alexander
Published: October 2018

La investigación evalúa el impacto del empleo de las plataformas e-learning, como alternativa educativa, en el aprendizaje de los estudiantes de las Universidades del Ecuador. Desde un enfoque cuantitativo y en un estudio de tipo descriptivo, el empleo del método Bibliográfico Documental, y la técnica de la encuesta posibilitó la identificación de los principales significados que sobre la implementación de esta modalidad educativa construyen los educandos. La utilización de las plataformas e-learning se generalizó en las Universidades, sin embargo, esta alternativa educativa no avanza positivamente debido fundamentalmente a la escasa preparación pedagógica, lo que va en detrimento de una formación autónoma, independiente y flexible propia de un aprendizaje significativo por parte del estudiantado.
Impacto de las simulaciones en el desarrollo de la autodirección en el estudiante de secundaria
Authors: Rodríguez Valdés María del Rosario Andrea , Turrubiates Corolla Miriam Lizzeth , Olivares Olivares Silvia Lizett
Published: October 2018

Este estudio analiza el impacto que tiene la estrategia de simulación en el desarrollo de la autodirección en alumnos de educación secundaria. Se realizaron recorridos virtuales a museos utilizando un objeto de aprendizaje, donde cada estudiante diseña y selecciona los puntos de su ruta. Cada recorrido considera los conocimientos previos del alumno considerando los elementos de la autodirección: cómo planifica y organiza, cuál es su manejo de las emociones y cómo reconoce sus habilidades para propiciar la mejora continua. Los resultados obtenidos, cuantitativos y cualitativos, permiten dar cuenta del efecto positivo que tiene este tipo de actividades en la  autodirección, específicamente en la elaboración de sus propias estrategias de aprendizaje.
Lead-lag series and staged parallel operational strategies improve the performance and cost-effectiveness of bonechar for control of fluoride in groundwater
Authors: Kearns J. , Krupp A. , Diek E. , Mitchell S. , Dossi S. , Hartman S.
Published: October 2018

Affordable, locally managed, decentralized treatment technologies are needed to protect health in resource-poor regions where communities consume groundwater containing elevated levels of fluoride (F). Bonechar is a promising low-cost sorbent for F that can be produced using local materials and simple pyrolysis technology. However, the sorption capacity of bonechar is low relative to the quantities of F that must be removed to meet health criteria (typically several mg/L), especially at pH typical of groundwaters containing high levels of geogenic F. This necessitates large bonechar contactors and/or frequent sorbent replacement, which could be prohibitively costly in materials and labor. One strategy for improving the feasibility of bonechar water treatment is to utilize lead-lag series or staged parallel configurations of two or more contactors. This study used column testing to quantify potential benefits to bonechar use rate, replacement frequency, and long-run average F concentration in treated water of lead-lag series and staged parallel operational modes compared with single contactor mode. Lead-lag series operation exhibited the largest reduction in bonechar use rate (46% reduction over single contactor mode compared with 29% reduction for staged parallel) and lowest long-run average F levels when treating central Mexican groundwater at pH 8.2 containing 8.5 mg/L F.
Challenges for modern wine production in dry areas: dedicated indicators to preview wastewater flows
Authors: Oliveira M. , Costa J. M. , Fragoso R. , Duarte E.
Published: October 2018

Wine production is an important socio-economic activity in Mediterranean countries. This study is focused on wine production under warm and dry climate conditions in south Portugal, in two major wine-producing regions (Tejo and Alentejo), characterized by small to medium sized wineries. Vineyards have been expanding in this region of Portugal, where about 50–70% of the vineyards are irrigated, increasing regional water demand. The aim of this study is to propose an integrative approach for wine production, where a simple calculation model has been developed and validated to preview water consumption and wastewater production, as functions of winemaking periods and type of processed grapes. Results revealed a global ratio of 2.2 ± 0.45 and 2.1 ± 0.17 Lwater/Lwine. Concerning dedicated indicators, 60–75% of the wastewater was produced during Period I and the red wine production represented a 50–64% increase in water consumption. This tool will enable winemakers to calculate Global and Dedicated Indicators, based on their own parameters, which provide information on flow volumes and peak flows. In this context, it will be possible to identify improvements for wastewater treatment and management towards water reuse as a promising solution for the wine sector in the framework of the circular economy.
Effect of ABCB1 Genotypes on the Pharmacokinetics and Clinical Outcomes of New Oral Anticoagulants: A Systematic Review and Meta-analysis
Authors: Xie Qiufen , Xiang Qian , Mu Guangyan , Ma Lingyue , Chen Shuqing , Zhou Shuang , Hu Kun , Zhang Zhuo , Cui Yimin , Jiang Jie
Published: October 2018

Background:

New Oral Anticoagulants (NOACs) are effective and widely used to prevent and treat
thromboembolic diseases, but the response to NOACs differs according to ABCB1 genotypes.

Objective:

We investigated the effects of ABCB1 genotypes on the pharmacokinetics and clinical outcomes of
NOACs.

Methods:

We searched PubMed, Embase, and the Cochrane Library for studies on ABCB1 genotypes published
from the inception of these databases until May 23, 2018. The Weighted Mean Difference (WMD) and Odds
Ratio (OR) with 95% Confidence Interval (CI) were calculated for continuous and dichotomous data, respectively.
Summary results were calculated using a random effects model.

Results:

Ten studies involving 2609 individuals were included in the systematic review, and three studies involving
535 individuals were included in the meta-analysis. Overall, four ABCB1 single-nucleotide polymorphisms
were identified in the review. Carriers of the ABCB1 rs1045642 CC genotype had lower maximum plasma concentration
(Cmax) than those of TT (WMD = −16.99 ng/mL; 95% CI = −33.39 to −0.59; P = 0.04), and carriers of
the rs2032582 GG genotype showed lower Cmax than those of the A/T allele (WMD = −19.21 ng/mL; 95% CI =
−36.62 to −1.80; P = 0.03). Carriers of the rs1045642 CC genotype showed lower area under the curve from time
0 to infinity (AUC0–∞) than those of the T allele (WMD = −78.58 ng·h/mL; 95% CI = −151.14 to −6.01; P =
0.03). ABCB1 rs4148738 genotypes did not affect the risks of ischemic stroke or systemic embolism (OR =
0.88), ischemic events (OR = 0.98), bleeding (OR = 0.94), major bleeding (OR = 1.14), or minor bleeding (OR =
0.94) in patients treated with dabigatran.

Conclusion:

Cmax was lower in carriers of ABCB1 rs1045642 CC than in those of TT and in carriers of rs2032582
GG than in those of the A/T allele, and AUC0–∞ was lower in carriers of rs1045642 CC than in those of TT. Conversely,
ABCB1 rs4148738 genotypes did not affect primary clinical endpoints in dabigatran-administered patients.
Future studies should analyze the relationships of ABCB1 genotypes with the pharmacokinetics and clinical
outcomes of specific NOACs.
Survey of Machine Learning Techniques for Prediction of the Isoform Specificity of Cytochrome P450 Substrates
Authors: Xiong Yi , Qiao Yanhua , Kihara Daisuke , Zhang Hui-Yuan , Zhu Xiaolei , Wei Dong-Qing
Published: October 2018

Background:

Determination or prediction of the Absorption, Distribution, Metabolism, and Excretion (ADME) properties of drug candidates and drug-induced toxicity plays crucial roles in drug discovery and development. Metabolism is one of the most complicated pharmacokinetic properties to be understood and predicted. However, experimental determination of the substrate binding, selectivity, sites and rates of metabolism is time- and recourse- consuming. In the phase I metabolism of foreign compounds (i.e., most of drugs), cytochrome P450 enzymes play a key role. To help develop drugs with proper ADME properties, computational models are highly desired to predict the ADME properties of drug candidates, particularly for drugs binding to cytochrome P450.

Objective:

This narrative review aims to briefly summarize machine learning techniques used in the prediction of the cytochrome P450 isoform specificity of drug candidates.

Results:

Both single-label and multi-label classification methods have demonstrated good performance on modelling and prediction of the isoform specificity of substrates based on their quantitative descriptors.

Conclusion:

This review provides a guide for researchers to develop machine learning-based methods to predict the cytochrome P450 isoform specificity of drug candidates.
Effects of Gut Microbiota on Drug Metabolism and Guidance for Rational Drug Use Under Hypoxic Conditions at High Altitudes
Authors: Zhang Juanhong , Zhang Junmin , Wang Rong , Jia Zhengping
Published: October 2018

Background:

Modern features of drug development such as low permeability, low solubility, and improved
release affect the interplay of the gut microbiota and drug metabolism. In recent years, studies have established
the impact of plateau hypoxia on gut microbiota, where drug use by plateau populations is affected by hypoxia-
induced changes in intestinal microflora-mediated drug metabolism.

Methods:

In this review, we summarized the effects of gut microbiota on drug metabolism, and of plateau hypoxia
on the intestinal flora, with the aim of providing guidance for the rational use of drugs in high-altitude populations.

Results:

The evidence clearly shows that alterations in gut microbiota can affect pro-drug activation, drug inactivation,
and the biotransformation of xenobiotics. Additionally, plateau hypoxia alters drug metabolism by affecting
intestinal flora.

Conclusion:

This review provides an overview of the effects of gut microbiota on drug metabolism and provides
guidance for rational drug use under hypoxic conditions at high altitudes.
A Review on Quinoline Derived Scaffolds as Anti-HIV Agents
Authors: Chokkar Nisha , Kalra Sourav , Chauhan Monika , Kumar Raj
Published: October 2018

After restricting the proliferation of CD4+T cells, Human Immunodeficiency Virus (HIV),
infection persists at a very fast rate causing Acquired Immunodeficiency Syndrome (AIDS). This demands
the vigorous need of suitable anti-HIV agents, as existing medicines do not provide a complete
cure and exhibit drawbacks like toxicities, drug resistance, side-effects, etc. Even the introduction of
Highly Active Antiretroviral Therapy (HAART) failed to combat HIV/AIDS completely. The major
breakthrough in anti-HIV discovery was marked with the discovery of raltegravir in 2007, the first integrase
(IN) inhibitor. Thereafter, the discovery of elvitegravir, a quinolone derivative emerged as the
potent HIV-IN inhibitor. Though many more classes of different drugs that act as anti-HIV have been
identified, some of which are under clinical trials, but the recent serious focus is still laid on quinoline
and its analogues. In this review, we have covered all the quinoline-based derivatives that inhibit various
targets and are potential anti-HIV agents in various phases of the drug discovery.
HSF1 as a Cancer Biomarker and Therapeutic Target
Authors: Carpenter Richard L. , Gökmen-Polar Yesim
Published: October 2018

Heat shock factor 1 (HSF1) was discovered in 1984 as the master regulator of the heat shock response. In this classical role, HSF1 is activated following cellular stresses such as heat shock that ultimately lead to HSF1-mediated expression of heat shock proteins to protect the proteome and survive these acute stresses. However, it is now becoming clear that HSF1 also plays a significant role in several diseases, perhaps none more prominent than cancer. HSF1 appears to have a pleiotropic role in cancer by supporting multiple facets of malignancy including migration, invasion, proliferation, and cancer cell metabolism among others. Because of these functions, and others, of HSF1, it has been investigated as a biomarker for patient outcomes in multiple cancer types. HSF1 expression alone was predictive for patient outcomes in multiple cancer types but in other instances, markers for HSF1 activity were more predictive. Clearly, further work is needed to tease out which markers are most representative of the tumor promoting effects of HSF1. Additionally, there have been several attempts at developing small molecule inhibitors to reduce HSF1 activity. All of these HSF1 inhibitors are still in preclinical models but have shown varying levels of efficacy at suppressing tumor growth. The growth of research related to HSF1 in cancer has been enormous over the last decade with many new functions of HSF1 discovered along the way. In order for these discoveries to reach clinical impact, further development of HSF1 as a biomarker or therapeutic target needs to be continued.
Gender Differences in the Antioxidant Response to Oxidative Stress in Experimental Brain Tumors
Authors: Ramírez-Expósito María Jesús , Mayas María Dolores , Carrera-González María Pilar , Martínez-Martos José Manuel
Published: October 2018

Background:

Brain tumorigenesis is related to oxidative stress and a decreased response of antioxidant defense systems. As it is well known that gender differences exist in the incidence and survival rates of brain tumors, it is important to recognize and understand the ways in which their biology can differ.

Objective:

To analyze gender differences in redox status in animals with chemically-induced brain tumors.

Methods:

Oxidative stress parameters, non-enzyme and enzyme antioxidant defense systems are assayed in animals with brain tumors induced by transplacental N-ethyl-N-nitrosourea (ENU) administration. Both tissue and plasma were analyzed to know if key changes in redox imbalance involved in brain tumor development were reflected systemically and could be used as biomarkers of the disease.

Results:

Several oxidative stress parameters were modified in tumor tissue of male and female animals, changes that were not reflected at plasma level. Regarding antioxidant defense system, only glutathione (GSH) levels were decreased in both brain tumor tissue and plasma. Superoxide dismutase (SOD) and catalase (CAT) activities were decreased in brain tumor tissue of male and female animals, but plasma levels were only altered in male animals. However, different protein and mRNA expression patterns were found for both enzymes. On the contrary, glutathione peroxidase (GPx) activity showed increased levels in brain tumor tissue without gender differences, being protein and gene expression also increased in both males and female animals. However, these changes in GPx were not reflected at plasma level.

Conclusion:

We conclude that brain tumorigenesis was related to oxidative stress and changes in brain enzyme and non-enzyme antioxidant defense systems with gender differences, whereas plasma did not reflect the main redox changes that occur at the brain level.
Virtual Screening Meets Deep Learning
Authors: Pérez-Sianes Javier , Pérez-Sánchez Horacio , Díaz Fernando
Published: October 2018

Background:

Automated compound testing is currently the de facto standard method for drug
screening, but it has not brought the great increase in the number of new drugs that was expected. Computer-
aided compounds search, known as Virtual Screening, has shown the benefits to this field as a complement
or even alternative to the robotic drug discovery. There are different methods and approaches to
address this problem and most of them are often included in one of the main screening strategies. Machine
learning, however, has established itself as a virtual screening methodology in its own right and it may
grow in popularity with the new trends on artificial intelligence.

Objective:

This paper will attempt to provide a comprehensive and structured review that collects the most
important proposals made so far in this area of research. Particular attention is given to some recent developments
carried out in the machine learning field: the deep learning approach, which is pointed out as a
future key player in the virtual screening landscape.
Synthesis of [18F]FAZA Using Nosyl and Iodo Precursors for Nucleophilic Radiofluorination
Authors: Sun William , Falzon Cheryl , Naimi Ebrahim , Akbari Ali , Wiebe Leonard I. , Tandon Manju , Kumar Piyush
Published: October 2018

Background: 1-α-D-(5-Deoxy-5-[18F]fluoroarabinofuranosyl)-2-nitroimidazole ([18F]FAZA)
is manufactured by nucleophilic radiofluorination of 1-α-D-(2’,3’-di-O-acetyl-5’-O-toluenesulfonylarabinofuranosyl)-
2-nitroimidazole (DiAcTosAZA) and alkaline deprotection to afford [18F]FAZA.
High yields (>60%) under optimized conditions frequently revert to low yields (<20%) in large scale,
automated syntheses. Competing side reactions and concomitant complex reaction mixtures contribute
to substantial loss of product during HPLC clean-up.

Objective: To develop alternative precursors for facile routine clinical manufacture of [18F]FAZA that
are compatible with current equipment and automated procedures.

Methods: Two new precursors, 1-α-D-(2’,3’-di-O-acetyl-5’-O-(4-nitrobenzene)sulfonyl-arabinofuranosyl)-2-
nitroimidazole (DiAcNosAZA) and 1-α-D-(2’,3’-di-O-acetyl-5’-iodo-arabinofuranosyl)-2-nitroimidazole
(DiAcIAZA), were synthesized from commercially-available 1-α-D-arabinofuranosyl-2-nitroimidazole
(AZA). A commercial automated synthesis unit (ASU) was used to condition F-18 for anhydrous radiofluorination,
and to radiofluorinate DiAcNosAZA and DiAcIAZA using the local standardized protocol
to manufacture [18F]FAZA from AcTosAZA.

Results: DiAcNosAZA was synthesized via two pathways, in recovered yields of 29% and 40%, respectively.
The nosylation of 1-α-D-(2’,3’-di-O-acetyl-arabinofuranosyl)-2-nitroimidazole (DiAcAZA) featured
a strong competing reaction that afforded 1-α-D-(2’,3’-di-O-acetyl-5’-chloro-arabinofuranosyl)-2-
nitroimidazole (DiAcClAZA) in 55% yield. Radiofluorination yields were better from DiAcNosAZA and
DiAcIAZA than from DiAcTosAZA, and the presence of fewer side products afforded higher purity
[18F]FAZA preparations. Several radioactive and non-radioactive by products of radiofluorination were
assigned tentative chemical structures based on co-chromatography with authentic reference compounds.

Conclusion: DiAcClAZA, a major side-product in the preparation of DiAcNosAZA, and its deprotected
analogue (ClAZA), are unproven hypoxic tissue radiosensitizers. DiAcNosAZA and DiAcIAZA provided
good radiofluorination yields in comparison to AcTosAZA and could become preferred
[18F]FAZA precursors if the cleaner reactions can be exploited to bypass HPLC purification.
Text Message Responsivity in a 2-Way Short Message Service Pilot Intervention With Adolescent and Young Adult Survivors of Cancer (Preprint)
Authors: Psihogios Alexandra M , Li Yimei , Butler Eliana , Hamilton Jessica , Daniel Lauren C , Barakat Lamia P , Bonafide Christopher P , Schwartz Lisa A
Published: October 2018

OBJECTIVE

Within a 2-way text messaging study in AYAs who recently completed treatment for cancer, we sought to evaluate text message responsivity across different types of text messages.

METHODS

AYAs who recently completed treatment for cancer (n=26; mean age=16 years; 62% female, 16/26 participants) received 2-way text messages about survivorship health topics over a 16-week period. Using participants’ text message log data, we coded responsivity to text messages and evaluated trends in responsivity to unprompted text messages and prompted text messages of varying content (eg, medication reminders, appointment reminders, and texts about personal experiences as a cancer survivor).

RESULTS

Across prompted and unprompted text messages, responsivity rapidly decreased (P ≤.001 and =.01, respectively) and plateaued by the third week of the intervention. However, participants were more responsive to prompted text messages (mean responsivity=46% by week 16) than unprompted messages (mean responsivity=10% by week 16). They also demonstrated stable responsivity to certain prompted content: medication reminders, appointment reminders, goal motivation, goal progress, and patient experience texts.

CONCLUSIONS

Our methodology of evaluating text message responsivity revealed important patterns of engagement in a 2-way text message intervention for AYA cancer survivors.
The Mesolithic Hunter-Gatherers in the Southeastern Mediterranean and Their Contribution in the Neolithisation of the Aegean
Authors: Sampson Adamantios
Published: October 2018

The excavations in the Aegean since the 1990s onwards have revealed a new cultural stage, starting from the beginning of 9th millennium down to the end of 8th. A network of sites extends from the northern to the southern Aegean Sea and from the West to the East, having as reference points the obsidian sources of Melos and Yali, Nissiros. In recent years, we have an increase of Mesolithic sites in the insular Aegean, the mainland Greece as well as in the western Asian coast, Cyprus and Crete. Recent research changes the data and shows that, along with the navigation capability and the specialization in fishing, an early Neolithisation in the Aegean began already in 9th millennium BC. It means that active Mesolithic groups from the early 9th mill. till the end of 8thcould have been able to travel to the East, interact with local populations of the PPNA and PPNB and transfer plants and animals, domesticated or not to the Aegean and the Greek mainland, contributing to the full Neolithisation of the area.
The impact of open access citation and social media on leading top Information Science journals
Authors: Cintra Paulo Roberto , Furnival Ariadne Chloe , Milanez Douglas Henrique
Published: October 2018

El objetivo de esta investigación fue verificar las posibles ventajas que el acceso abierto puede ofrecer al área de la Ciencia de la Información. Para ello, se analizaron los indicadores bibliométricos de citas y los datos de altmetría en 16 revistas científicas híbridas, seleccionadas mediante el Journal Citation Reports y filtradas con base en sus respectivos factores de impacto. La recolección de datos fue realizada en Web of Science, Google Scholar, Altmetric.com y Mendeley. Esta verificación se realizó en dos periodos de tiempo diferentes para examinar si hubo alguna influencia del acceso abierto en el tiempo. Los resultados indican que el acceso abierto puede ofrecer una ventaja en el número de citas y menciones en las redes sociales para el conjunto de artículos de las revistas analizadas aquí, y que esta ventaja es mayor para los casos en que los autores pagaron el cargo por procesamiento del artículo a garantizar la disponibilidad inmediata del artículo en acceso abierto al momento de la publicación. En la conclusión se afirma que no es sólo el acceso abierto el que provoca una mayor cantidad de citas a un artículo, aunque ayuda, sino la calidad del propio artículo.
Escritores académicos: retos y dificultades
Authors: Cabrera Carlos Enrique
Published: October 2018

En este ensayo se define el escritor académico y se muestran los retos y las dificultades a que se ve enfrentado en su ardua labor de escritura en la universidad. Además, se señala cómo para esta difícil tarea de la escritura académica, con sus exigentes particularidades, no se le proporciona, por lo general, el adecuado y sostenido entrenamiento, por lo que muchos de estos escritores suelen verse frustrados ante los pobres resultados obtenidos tras sus grandes esfuerzos, viéndose abocados con frecuencia a la deserción. Por último, se plantea de forma somera cómo las universidades anglosajonas han buscado solventar esta crítica situación que impacta de forma tan negativa el desempeño de los estudiantes universitarios, mientras las academias iberoamericanas (salvo algunas honrosas excepciones) no acometen con decisión y contundencia soluciones eficaces.
Desafios e possibilidades no processo de avaliação da aprendizagem de estudantes com deficiência visual na universidade
Authors: Pieczkowski Tania Mara Zancanaro , Grapilha Jiovana
Published: October 2018

A avaliação da aprendizagem é um tema desafiador e avaliar estudantes com deficiência visual é ainda mais complexo. O estudo objetivou identificar e analisar os desafios docentes na avaliação da aprendizagem de estudantes cegos ou com baixa visão na universidade e as tecnologias assistivas que favorecem as práticas avaliativas. Para desenvolver a pesquisa, realizamos entrevistas narrativas com docentes atuantes com estudantes com deficiência visual no primeiro semestre de 2016, tendo como critério o maior tempo de atuação docente na instituição pesquisada. As entrevistas foram gravadas, transcritas, organizadas em agrupamentos temáticos e analisadas com base na análise de discurso, com amparo em referenciais Foucaultianos. A maioria dos docentes declarou o desafio de estar atento e contemplar as singularidades de cada aluno e relatou que aprendeu a trabalhar com os estudantes com deficiência visual, contando especialmente com os ensinamentos que os próprios estudantes difundiram.
BREVES CONSIDERAÇÕES SOBRE A FORMAÇÃO DOCENTE E A PRÁTICA PEDAGÓGICA: APRESENTAÇÃO
Authors: Dos Santos Felício Helena Maria , De Jesus Brandão Isabel Cristina , Ribeiro da Silva Carlos Manuel
Published: October 2018

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POLÍTICAS PÚBLICAS PARA FORMAÇÃO INICIAL E CONTINUADA DE PROFESSORES DA EDUCAÇÃO INFANTIL
Authors: Motta Geani Oliveira , De Jesus Brandão Isabel Cristina , Souza Jorsinai De Argolo
Published: October 2018

O presente artigo apresenta como objeto de estudo a formação inicial e continuada para os professores da Educação Infantil, destacando o cenário da política de formação dos professores no país em aspectos que perpassam pelo processo histórico e pelos marcos legais em um contexto de conflitos e contradições. Evidenciam-se os desafios para a formação de professores para a Educação Infantil, com o intuito de ampliar os debates sobre as concepções de formação inicial e continuada, considerando-se as necessidades, as potencialidades, a cultura, o desenvolvimento e a aprendizagem das crianças, bem como as complexidades do cenário político atual que repercutem nas políticas de formação dos professores.
A FORMAÇÃO INICIAL, A PRÁTICA PEDAGÓGICA E O PROCESSO DE TORNAR-SE PROFESSOR
Authors: De Amorim Aline Diniz , Da Silva Fernandes Maria José
Published: October 2018

O presente texto objetiva discutir potencialidades e fragilidades da formação inicial de professores para o exercício da profissão, tendo como referência a prática pedagógica. O professor dos anos iniciais do Ensino Fundamental e da Educação Infantil, considerado polivalente, vivencia inquietações e anseios no início da carreira que são gerados, na maioria das vezes, por fragilidades da formação inicial que não consideram a atuação em sala de aula e a articulação teoria e prática. A discussão pauta-se em dados coletados por meio de entrevistas com seis professores iniciantes graduados no curso de Pedagogia numa instituição pública de ensino superior do interior do estado de São Paulo. Como principais resultados constata-se que a formação inicial é reconhecida, pelos entrevistados, como base fundamental para a preparação e exercício da docência, contudo, os professores apontaram os limites desta formação, destacando especialmente a desvalorização da dimensão prática da profissão que deveria ser complementar à formação teórica. Os sujeitos entrevistados vivenciaram grandes desafios ao adentrarem o espaço escolar, deparando-se com elementos centrais do trabalho que, por não terem sido adequadamente explorados ao largo da formação, lhes pareciam novidades. Ao lado dos desafios, os respondentes também apontaram significativas aprendizagens obtidas na relação com os professores experientes e com os gestores escolares, ressaltando a importância da socialização da prática para a atuação profissional. Neste sentido, a pesquisa apontou a fragilidade ainda marcante na formação inicial no que tange à dimensão da prática pedagógica, indicando que os resultados das pesquisas não têm sido adequadamente incorporados à preparação dos professores.
EXPRESSÕES DA “DOCÊNCIA COMPARTILHADA” NA FORMAÇÃO INICIAL DE PROFESSORES
Authors: Felício Helena , Schiabel Daniela
Published: October 2018

Este texto objetiva problematizar a Docência Compartilhada enquanto estratégiametodológica/formativa, no interior da prática pedagógica, a partir dos significados atribuídos pelasacadêmicas do curso de Pedagogia à esta experiência. Deste modo, realizamos a coleta dasinformações a partir dos relatos em reuniões com acadêmicas que participam do ProgramaInstitucional de Bolsas de Iniciação à Docência (PIBID) e dos registros coletivos construídos no“google drive” de março a junho de 2017. Para a análise dos resultados, nos servimos dos pressupostosda epistemologia qualitativa construtiva interpretativa, buscando a apreensão de significados na falados sujeitos, interligados ao contexto em que eles se inserem. Assim, foi possível evidenciar elementosque apontam para tensões, como a desmotivação profissional, que se explicita na ausência de relaçõeshorizontais entre professor e acadêmica e na falta de autonomia do professor nas decisões pedagógicaspara sua sala de aula. Em contrapartida, identificamos possibilidades reverberadas no trabalhocoletivo/colaborativo e no diálogo. Deste modo, conscientes de que a profissionalidade docente seconstrói entre tensões e possibilidades, assumimos a Docência Compartilhada como uma importanteestratégia metodológica que contribui para a formação dos futuros professores, na medida em que elaoferece a possibilidade de, ainda na formação inicial, aproximar-se da complexidade que compreendea sala de aula, bem como fazer o exercício da integração dos elementos aprofundados no campoteórico.
FORMAÇÃO DE PROFESSORES PARA A EDUCAÇÃO PROFISSIONAL: SOBRE POLÍTICAS E PERSPECTIVAS
Authors: Alves Damascena Edilza , Henrique Moura Dante
Published: October 2018

Este trabalho apresenta, de forma sintética, os resultados de uma pesquisa que teve comoobjeto a formação de professores para a educação profissional e como objetivo geral analisar aspolíticas de formação de docentes para a educação profissional e sua implementação em duasinstituições que ofertam essa modalidade no Vale do Açu (RN). O estudo fundamenta-se em autorescomo Machado (2008, 2013), Kuenzer (2011), Moura (2013, 2014), dentre outros, bem como naanálise de dispositivos legais, como a “Lei de Diretrizes e Bases da Educação Nacional” n. 9.394/1996e os Decretos e Resoluções que tratam da temática. Nosso referencial teórico é o pensamentosociocrítico, pois compreendemos que o objeto de estudo está inserido em uma realidade contraditóriae, portanto, dialética, cujo desvelamento exige, entre outras demandas, a análise do contextoeconômico, político, social e cultural. Para atingir nossos objetivos, realizamos revisão bibliográfica,análise documental e pesquisa de campo através de aplicação de questionário. O trabalho revela acarência de uma política nacional de Estado (perene) que contemple as demandas específicas deformação para os docentes que atuam na modalidade da educação profissional, sendo realizadas açõesmais de caráter emergencial, fragmentário e provisório. Desse modo, na concreticidade da realidadeanalisada, os profissionais cuja formação inicial é diversa da área da educação exercem a docência naeducação profissional sem que para tanto tenham, em sua maioria, passado por processo formativoespecífico.
JOGO PEDAGÓGICO E EXPRESSÃO PLÁSTICA NA MOTIVAÇÃO DAS APRENDIZAGENS ESCOLARES – CONTRIBUTOS DO PROJETO CURRICULAR INTEGRADO
Authors: Ribeiro da Silva Carlos Manuel , Martins Abreu Joana
Published: October 2018

A escola contemporânea depara-se com a necessidade de estabelecer estratégias pedagógicas e métodos de ensino e aprendizagem que contribuam para o desenvolvimento harmonioso da criança e do seu sucesso escolar. Este panorama requer dos professores uma reflexão das práticas educativas, privilegiando modelos pedagógicos diferenciadores que respeitem a individualidade do aluno, contribuindo para o enriquecimento do contexto educativo e motivação dos alunos para a aprendizagem. Algumas estratégias pedagógicas diferenciadoras, corroboradas por investigadores da área, permeiam o desenvolvimento de atividades lúdico-pedagógicas e recreativas, desenvolvidas sob a forma de jogos pedagógicos e de atividades de expressão plástica, que aliadas aos conteúdos programáticos, motivam e mobilizam os alunos para o desenvolvimento de aprendizagens significativas, pela sua vertente prática e lúdica. O trabalho tem como objetivo analisar as potencialidades dos jogos lúdico-pedagógicos e da expressão plástica na motivação das aprendizagens escolares numa turma do 2.º ano de escolaridade, do 1.º Ciclo. A partir de uma metodologia de investigação-ação de natureza qualitativa, os resultados do estudo sugerem que os jogos lúdico-pedagógicos e a expressão plástica constituem-se como fatores de potenciação da motivação e do trabalho cooperativo, permitindo despoletar uma predisposição do grupo-turma para a realização de novas aprendizagens. Concluímos com uma reflexão que estabelece um vínculo significativo entre educação e ciência e de como esta relação deve influenciar os pressupostos da formação de professores, nomeadamente os que são subjacentes ao constructo de projeto curricular integrado na concretização das experiências de aprendizagem escolar e de formação de professores.
A TRANSFORMAÇÃO DAS PRÁTICAS PROFISSIONAIS DOCENTES TENDO COMO REFERÊNCIA A METODOLOGIA TELESSALATM
Authors: Mendonça Ana Teresa Pollo , Cosme Ariana
Published: October 2018

Nesse artigo analisam-se as transformações nas práticas pedagógicas de educadores que utilizaram a Metodologia TelessalaTM no Programa Autonomia entre 2009 e 2015, uma parceria entre a Fundação Roberto Marinho (FRM) e a Secretaria de Estado de Educação do Rio de Janeiro (SEEDUC), Brasil, que visava a aceleração de estudos para a conclusão da Educação Básica de alunos em distorção idade-série. Procura-se compreender quais as mudanças que ocorreram na sua identidade profissional e pessoal a partir do trabalho com a unidocência, interdisciplinar e organizado de forma modular e não seriada; com um currículo contextualizado, problematizado e vivenciado através de uma dinâmica em que o professor assume o papel de mediador pedagógico e o conhecimento é construído coletivamente junto aos educandos, divididos em quatro Equipes. Para esse trabalho, os docentes passaram por um processo de formação continuada, no início de cada módulo, onde se esperava que fortalecessem pressupostos teórico-metodológicos, como a Leitura de Imagem e a escrita do Memorial e dialogassem com outras experiências; durante os acompanhamentos pedagógicos em sala de aula e nos encontros de planejamento em grupo, que objetivavam identificar as suas conquistas e dar atenção aos desafios.
FLECHA DO TEMPO: ORIGEM DO PENSAMENTO, CONHECIMENTO E REPRESENTAÇÃO DA REALIDADE POR INDÍGENAS
Authors: Soares Marta Genú , Alencar Joelma Cristina Parente , Da Silva Messias Furtado , Faro Carmen Lilia da Cunha
Published: October 2018

Este artigo apresenta a análise da experiência de docentes com grupos indígenas a partir do registro da vivência metodológica de construção do conhecimento sobre epistemologia e história da ciência ocidental. Usa diário de campo e a lógica adotada pelo coletivo trabalhado desde o estudo da realidade dos grupos, a organização do conhecimento, o conteúdo sistematizado e os saberes do cotidiano, e a aplicação do conhecimento elaborado nas situações de ensino vivenciadas in loco. Adota a descrição da experiência e a apreciação crítica por meio de diálogo com o referencial teórico, acrescido da reflexão crítica de conceitos como interculturalidade, identidade, ética e organização social. Ratifica que o conhecimento é construção singular, histórico e situado que requer registro para identidade social e produção cultural.
Preparation of inverse opal zirconia
Authors: Li Xiao-Peng , Wang Li-Li , Gong Zai-Lei , Wang Xiu-Feng , Zhou Ye-Ming
Published: October 2018

Inverse opal zirconia is useful in many ways because of their ability to
combine several chemical and physical properties. In this research,
polystyrene template was fabricated by self-assembly method and inverse opal
zirconia was prepared by colloidal crystal-templating method. The process of
preparation of inverse opal zirconia as well as effects on morphology and
phase of as-prepared inverse opal zirconia were studied. The results showed
precursor ratio of zirconium acetate and methanol, mass ratio of polystyrene
templates and precursor and dipping times had remarkable influence on
morphology of inverse opal zirconia. When the precursor ratio was 1:1; the
mass ratio was 1:15 and dipped once, much better morphology of inverse opal
zirconia was obtained. The mass ratio, sintering temperature and holding
time had significant effect on crystallization of zirconia. Pure phase
zirconia could be obtained when sintered at 600 oC, holding time was 2h and
the mass ratio was 1:1. A distinguished single stop band in the visible
region of the spectrum and unique structural color were observed in inverse
opal zirconia, which will make this material promising candidate for novel
pigment.