bluuebunny/crossref_metadata_2025 huggingface dataset:
Preservação do Patrimônio Artístico:
Authors: Mackert Pascoal Niara
Published: June 2024

A videoarte surgiu a partir da década de 1960, trazendo consigo diversas discussões e rupturas em relação à visão de arte da época. Configura-se, desde seu surgimento, como uma das vertentes de arte contemporânea, tornando-se importante dentro do contexto artístico atual. Sua importância enquanto  produção artística transfere igual relevância a todas as informações e acervos sobre sua historicidade e desenrolar ao longo do tempo. Tendo isso em vista, este artigo tem como objetivo refletir sobre a constituição do Acervo de Videoarte da Fundação Joaquim Nabuco (Recife - PE) e sua pertinência enquanto promotor de arte e enquanto preservação do patrimônio artístico. Para isso, realizou-se uma pesquisa bibliográfica e documental, utilizando notícias publicadas em jornais e documentos institucionais, em vista de organizar o maior número possível de informações sobre o acervo que configura-se como um dos maiores da América Latina.
Core regions in immunoglobulin heavy chain enhancers essential for survival of non-Hodgkin lymphoma cells are identified by a CRISPR interference screen
Authors: Kasprzyk Marta Elżbieta , Sura Weronika , Podralska Marta , Kazimierska Marta , Seitz Annika , Łosiewski Wojciech , Woźniak Tomasz , Guikema Jeroen E. J. , Diepstra Arjan , Kluiver Joost , Van den Berg Anke , Rozwadowska Natalia , Dzikiewicz-Krawczyk Agnieszka
Published: June 2024

Chromosomal translocations in non-Hodgkin lymphoma (NHL) result in activation of oncogenes by placing them under the regulation of immunoglobulin heavy chain (IGH) super-enhancers. Aberrant expression of translocated oncogenes induced by enhancer activity can contribute to lymphomagenesis. The role of the IGH enhancers in normal B-cell development is well established, but knowledge regarding the precise mechanisms of their involvement in control of the translocated oncogenes is limited. The goal of this project was to define the critical regions in the IGH regulatory elements and identify enhancer RNAs (eRNA). We designed a sgRNA library densely covering the IGH enhancers and performed tiling CRISPR interference screens in three NHL cell lines. This revealed three regions crucial for NHL cell growth. With chromatin-enriched RNA-Seq we showed transcription from the core enhancer regions and subsequently validated expression of the eRNAs in a panel of NHL cell lines and tissue samples. Inhibition of the essential IGH enhancer regions decreased expression of eRNAs and translocated oncogenes in several NHL cell lines. The observed expression and growth patterns were consistent with the breakpoints in the IGH locus. Moreover, targeting the Eμ enhancer resulted in loss of B-cell receptor expression. In a Burkitt lymphoma cell line, MYC overexpression partially rescued the phenotype induced by IGH enhancer inhibition. Our results indicated the most critical regions in the IGH enhancers and provided new insights into the current understanding of the role of IGH enhancers in B-cell NHL. As such, this study forms a basis for development of potential therapeutic approaches.
Lysosomal acid lipase A modulates leukemia stem cell response to venetoclax/tyrosine kinase inhibitor combination therapy in blast phase chronic myeloid leukemia
Authors: Minhajuddin Mohd , Winters Amanda , Ye Haobin , Pei Shanshan , Stevens Brett , Gillen Austin , Engel Krysta , Gipson Stephanie , Ransom Monica , Amaya Maria , Inguva Anagha , Gasparetto Maura , Althoff Mark J. , Miller Regan , Shelton Ian , Tolison Hunter , Krug Anna , Culp-Hill Rachel , D’Alessandro Angelo , Sherbenou Daniel W , Pollyea Daniel A. , Smith Clayton , Jordan Craig T
Published: June 2024

The treatment of blast phase chronic myeloid leukemia (bpCML) remains a challenge due at least in part to drug resistance of leukemia stem cells (LSCs). Recent clinical evidence suggests that the BCL-2 inhibitor venetoclax in combination with ABL-targeting tyrosine kinase inhibitors (TKIs) can eradicate bpCML LSCs. In this report, we employed preclinical models of bpCML to investigate the efficacy and underlying mechanism of LSC-targeting with venetoclax/TKI combinations. Transcriptional analysis of LSCs exposed to venetoclax and dasatinib revealed upregulation of genes involved in lysosomal biology, in particular lysosomal acid lipase A (LIPA), a regulator of free fatty acids. Metabolomic analysis confirmed increased levels of free fatty acids in response to venetoclax/dasatinib. Pre-treatment of leukemia cells with bafilomycin, a specific lysosome inhibitor, or genetic perturbation of LIPA, resulted in increased sensitivity of leukemia cells toward venetoclax/dasatinib, implicating LIPA in treatment resistance. Importantly, venetoclax/dasatinib treatment does not affect normal stem cell function, suggestive of a leukemia-specific response. These results demonstrate that venetoclax/dasatinib is an LSCselective regimen in bpCML and that disrupting LIPA and fatty acid transport enhances venetoclax/dasatinib response in targeting LSCs, providing a rationale for exploring lysosomal disruption as an adjunct therapeutic strategy to prolong disease remission.
Blockade of the CD47/SIRPα checkpoint axis potentiates the macrophage-mediated anti-tumor efficacy of tafasitamab
Authors: Biedermann Alexander , Patra-Kneuer Maria , Mougiakakos Dimitrios , Büttner-Herold Maike , Mangelberger-Eberl Doris , Berges Johannes , Kellner Christian , Altmeyer Sarah , Bittenbring Jörg Thomas , Augsberger Christian , Ilieva-Babinsky Kristina , Haskamp Stefan , Beier Fabian , Lischer Christopher , Vera Julio , Lührmann Anja , Bertz Simone , Völkl Simon , Jacobs Benedikt , Steidl Stefan , Mackensen Andreas , Bruns Heiko
Published: June 2024

Macrophages are one of the key mediators of the therapeutic effects exerted by monoclonal antibodies, such as the anti-CD19 antibody tafasitamab, approved in combination with lenalidomide for the treatment of relapsed or refractory (r/r) diffuse large B cell lymphoma (DLBCL). However, antibody-dependent cellular phagocytosis (ADCP) in the tumor microenvironment can be counteracted by increased expression of the inhibitory receptor SIRPα on macrophages and its ligand, the immune checkpoint molecule CD47 on tumor cells. The aim of this study was to investigate the impact of the CD47-SIRPα axis on tafasitamabmediated phagocytosis and explore the potential of anti-CD47 blockade to enhance its antitumor activity. Elevated expression of both SIRPα and CD47 was observed in DLBCL patient-derived lymph node biopsies compared to healthy controls. CRISPR-mediated CD47 overexpression impacted tafasitamab-mediated ADCP in vitro and increased expression of SIRPα on macrophages correlated with decreased ADCP activity of tafasitamab against DLBCL cell lines. Combination of tafasitamab and an anti-CD47 blocking antibody enhanced ADCP activity of in vitro generated macrophages. Importantly, tafasitamab-mediated phagocytosis was elevated in combination with CD47 blockade using primary DLBCL cells and patient-derived lymphoma-associated macrophages (LAMs) in an autologous setting. Furthermore, lymphoma cells with low CD19 expression were efficiently eliminated by the combination treatment. Finally, combined treatment of tafasitamab and an anti-CD47 antibody resulted in enhanced tumor volume reduction and survival benefit in lymphoma xenograft mouse models. These findings provide evidence that CD47 blockade can enhance the phagocytic potential of tumor targeting immunotherapies such as tafasitamab and suggest there is value in exploring the combination in the clinic.
Integration of genotypic data into clinical trial design and reporting in hereditary hemorrhagic telangiectasia could help personalize treatment
Authors: Modarresi Atieh , Shovlin Claire L.
Published: June 2024

Not available.
Libro guía para la enseñanza de la cátedra de moldería
Authors:   Universidad del Azuay, Galindo-Zeas Ruht
Published: June 2024

El mundo de la moda es un campo en constante evolución que requiere una preparación y actualización continua. Es importante tener en cuenta que se trata de un ámbito que exige precisión y organización; y que abarca una amplia variedad de universos vestimentarios, incluyendo ropa para niños, adolescentes, mujeres, hombres, alta costura, sastrería y ropa para actividades específicas como teatro, cocina y baile. Con el propósito de ofrecer a los estudiantes una formación integral y facilitarles el acceso a información relevante sobre la cátedra de moldería, se presenta este libro guía que ofrece detalles sobre las formas corporales, la toma de medidas, las proporciones y el trazo de patrones básicos. Este documento es el resultado de una extensa investigación, experimentación y aplicación de diferentes métodos de patronaje, que han sido sometidos a distintos cambios y variaciones para lograr un resultado eficiente. Se espera que esta propuesta contribuya a fortalecer el aprendizaje de los estudiantes en sus primeros años de estudio y sea una referencia constante en su formación en el campo de la moda. Además, servirá como base para futuros niveles de enseñanza en el área de Moldería. 78 páginas ISBN: 978-9942-645-90-6
Hermanas
Authors:   Universidad del Azuay, Araya Sandra , Larriva-Calle Felipe ,   Universidad del Azuay, Tripaldi-Proaño Anna ,   Universidad del Azuay
Published: June 2024

Huyendo de algún virus inominado, la joven protagonista de este cuento se refugia junto a su familia en la casa de una tía que parece albergar un perverso propósito. Allí la narradorea encuentra a Alda, una adolescente más sinuosa y compleja que la mayoría de su edad. Entre ambas no tarda en surgir una extraña mezcla de atracción y repulsión cuyo final es tan inquietante como ambiguo. Con una prosa compacta y poética. Sandra Araya nos sumerge en una envolvente atmósfera de tensiones morales y eróticas que evidencia la madurez de su arte narrativo. 126 páginas ISBN 978-9942-645-78-4
PENYULUHAN TENTANG ROBOT BERODA GUNA MENINGKATKAN KREATIFITAS SISWA SMA NEGERI 8 KOTA BENGKULU DIBIDANG ROBOTIKA
Authors: Suzantry Handayani Yanolanda , Kurniawan Adhadi , Fitria Edriani Annisa
Published: June 2024

Pengabdian ini membahas tentang dengan memberikan penyuluhan tentang robot beroda dapat meningkatkan kreatifitas siswa di SMA Negeri 8 Kota Bengkulu khususnya dibidang robotika. Rumusan masalahnya adalah bagaimana meningkatkan kreatifitas siswa SMA Negeri 8 Kota Bengkulu dibidang robotika. Metode Pengabdian Pada Masyarakat (PPM) ini terdiri dari metode ceramah dan evaluasi. Metode ceramah memberikan pemahaman dan materi langsung yang disampaikan tim dosen dibidang robotika. Sedangkan metode evaluasi adalah mengevaluasi pemahaman para peserta melalui angket pertanyaan apakah para peserta sudah faham dengan materi robot beroda. Dari kegiatan pengabdian didapat hasil bahwa siswa/i SMA Negeri 8 Kota Bengkulu memiliki rasa antusias atau tertarik dibidang robot beroda terlihat dari pertanyaan-pertanyaan yang dilontarkan oleh siswa/i SMA Negeri 8 Kota Bengkulu. Disamping itu ilmu robotika merupakan modal awal untuk bisa memasuki ke jenjang universitas dibidang elektro peminatan robotika.
Sosialisasi Pemanfaatan Pembangkit Listri Tenaga Surya (PLTS) Sebagai Sumber Energi Listrik Terbarukan di SMA Negeri 8 Kota Bengkulu
Authors: Anggraini Ika Novia , Herawati Afriyastuti , Rinaldi Reza Satria
Published: June 2024

Kebutuhan akan energi selalu mengalami peningkatan setiap tahunnya. Salah satu solusi yang dihadirkan untuk memenuhi kebutuhan energi tersebut adalah dengan pemanfaatan energi terbarukan, salah satunya yaitu Pembangkit Listrik Tenaga Surya (PLTS).  Dalam rangka meningkatkan pengetahuan masyarakat mengenai PLTS baik dari segi manfaat maupun cara pemasangannya, maka pemerintah Indonesia dalam hal ini melalui Kementerian Pendidikan dan Kebudayaan telah memasukkan materi mengenai sumber energy terbarukan ke dalam kurikulum pembelajaran di sekolah-sekolah baik di tingkat SD, SMP maupun SMA agar masyarakat Indonesia sejak dini sudah memahami mengenai pentingnya menggunakan energy terbarukan.Salah satu kegiatan sosialisasi dilakukan di SMA Negeri 8 Kota Bengkulu yang dilakukan pada tanggal 9 Maret 2022. Metode yang digunakan  dalam  kegiatan pengabdian masyarakat ini dengan cara memberikan sosialisasi berupa ceramah dan tanya jawab seputar pembangkit listrik tenaga surya baik secara teori maupun aplikasinya. Dari kegiatan  ini diharapkan dapat meningkatkan atau menambah pengetahuan bagi siswa-siswi SMA Negeri 8 Kota Bengkulu.
Sosialisasi Dan Edukasi Alur Pelayanan Pendaftaran Pasien dan Pencegahan Penyebaran Covid-19 Pasca Pandemi di Rumah Sakit Harapan Dan Do’a Kota Bengkulu
Authors: Arifin Ismail , Duri Iin Desmiany
Published: June 2024

Program Pengabdian Kepada Masyarakat ini dilaksanakan dengan tujuan untuk memberikan penyuluhan sosial atau sosialisasi sekaligus memberikan edukasi terkait dengan penanganan dan pencegahan penyebaran virus Covid 19 dalam rangka menciptakan keamanan dari penyebaran covid-19 dbagi pendaftaran pasien di RSHD Kota Bnegkulu. Target utama dari program Pengabdian Kepada Masyarakat ini adalah masyarat yaitu pasien yang berobat/berkunjung ke RSHD Kota Bengkulu, dengan pertimbangan bahwa RSHD merupakan Rumah Sakit rujukan Virus COVID-19. Kegiatan PKM ini dilaksanakan oleh Tim Pengabdian Kepada Masyarakat (PKM) untuk memberikan wawasan atau edukasi kepada pasien di RSHD Kota Bengkulu mengenai beberapa hal dalam menangani dan mencegah penyebaran Virus COVID-19 terutama dibagian pelayanan pendaftaran pada masa New Normal. Metode pelaksanaan PKM ini berupa sosialisasi dan edukasi melalui pendampingan dan penyuluhan. Dengan adanya program PKM melalui sosialisasi dan edukasi ini, diharapkan target masyarakat pasien di RSHD Kota Bengkulu dapat mengurangi kepanikan terhadap virus Covid 19, tercipta peningkatan pemahaman masyarakat mengenai Covid-19, tercipta suatu strategi gerakan mencegah dan mengantisipasi penyebaran Covid-19 di Rumah sakit tercipta media edukasi yang bisa menjadi pegangan masyarakat dalam menghadapi penyebaran virus corona, serta tetap menerapkan protokol kesehatan walau terdapat penurunan tingkat penyebaran sampai pemerintah memberikan instruksi di tahapan kehidupan selanjutnya.
Pelatihan Penggunaan Sistem Informasi Whatsapp Blast untuk Meningkatkan Response Rate Tracer Study Pendidikan Vokasi di SMKN 1 Bengkulu
Authors: Wijanarko Andang , Erlanshari Aan , Susilo Boko
Published: June 2024

Pelaksanaan tracer study pendidikan vokasi di SMKN 1 Kota Bengkulu dijalankan oleh tim Bursa Kerja Khusus (BKK)mengalami banyak hambatan, sehingga jumlah alumni yang mengisi tracer study masih sangat sedikit. Salah satu hambatannya yaitu tidak terdapat fasilitas-fasilitas atau inovasi yang diberikan oleh pihak sekolah untuk membantu tim BKK melakukan komunikasi yang intens kepada para alumni. Oleh karena itu, SMKN 1 Kota Bengkulu sangat membutuhkan sebuah sistem informasi untuk memberikan informasi kepada para alumni tentang betapa pentingnya mengisi survei di platform tracer study melalui teknologi whatapp blast. Metode pelaksanaan kegiatan pengabdian kepada masyarakat yang dilakukan secara umum dilakukan melalui tahapan analisis, desain, implementasi, serta pelatihan dan evaluasi. Hasil dari kegiatan pengabdian kepada masyarat ini yaitu sistem informasi whatsapp blast berbasis website berhasil dibangun menggunakan bahasa pemrograman PHP, HMTL, CSS Javascript dan MySQL, dengan tujuan untuk meningkatkan response rate tracer study di SMKN 1 Kota Bengkulu. Berdasarkan evaluasi kegiatan yang telah dilakukan, tim BKK SMKN 1 Kota Bengkulu secara umum berpendapat bahwa sistem whatsapp blast sangat membantu dalam operasional kegiatan tracer study. Diharapkan sistem whatsapp blast yang dibangun dapat meningkatkan jumlah response rate atau dengan kata lain dapat meningkatkan jumlah alumni yang mengisi survei pada platform tracer study vokasi pada periode terdekat.
Myxofibrosarcoma of The Abdominal Wall at Moewardi Hospital, Surakarta: A Rare Case Report
Authors: Soewoto Widyanti , Ismail Erwin Aritama , Bellynda Monica
Published: June 2024

Introduction: Myxofibrosarcoma (MFS) is a fibroblast-derived sarcoma, which accounts for approximately 5–10% of all soft tissue malignant tumors. The mean age in patients with MFS is between the fifth and seventh decades. Around 77% of MFS cases occur in the upper extremities. Other areas of the body including the trunk (12%), retroperitoneum or mediastinum (8%), abdominal wall, and heart have also been reported. Case Presentation: A 57-year-old Indonesian female visited our center with complaints of a lump in the left lower abdomen for 4 months. The lump has grown rapidly in the last two months. A contrast abdominal MRI examination found a soft tissue mass on the left lumbar abdominal wall to the left iliac with a size of 15 x 11,4 x 13,4 cm and bordered by part of the left external oblique muscle and the left internal oblique muscle pushing the intestinal system medially. The biopsy of the mass revealed a high-grade myxofibrosarcoma. The patient underwent a wide excision with an elliptical incision design, with in-toto removal of the lump. The immunohistochemical result of the tumor showed high-grade myxofibrosarcoma with free margins at the incision margin. Follow-up was performed at 1 month, 6 months, and 12 months postoperatively. The patient did not receive radiotherapy. Conclusions: This report describes a rare case of MFS of the abdominal wall. Recognizing the histopathological features of MFS and applying the appropriate immunohistochemical examinations are crucial in establishing the correct diagnosis. This case provides a diagnosis and treatment experience of MFS that occurs in the abdominal wall.
An Overview of The Spinal Metastasis Pain with Opioid Therapy and The Affecting Factor
Authors: Djohansjah Joice Rosewitasari Aryanti , Andriani Rini , Aninditha Tiara , Sofyan Henry Riyanto
Published: June 2024

Background: Spinal metastasis is the most frequent type of spinal tumor. Opioid is the first line of treatment for cancer pain despite a multitude of side effects. This study aimed to evaluate the effectiveness of opioids as the latest ladder in the treatment of spinal cancer pain. Methods: A retrospective cross-sectional study was performed comprising 89 spinal metastasis patients at the National Cancer Centre, Dharmais Hospital from November 2021 to March 2022. The demographic and clinical data were retrieved from medical records. This study used the Numerical Rating Scale (NRS) to evaluate the improvement of pain. The change of NRS ≥ 2 was considered significant. The data was analyzed using bivariate (Wilcoxon, Mann-Whitney, and Fisher Exact test) and multivariate (linear regression) analysis. Results: A total of 89 subjects were included in the study (median age = 51 years, 57,3% females). There was a significant decrease in the severity of cancer pain (p0.005) between admission (initial NRS 7) and treatment completion (final NRS 2) in the first hospitalization of all groups. There was no correlation between the clinical characteristics of the participants and the NRS score determined upon admission and at the end of the course of treatment. Conclusions: There was a significant improvement in the cancer pain intensity in the subjects with spinal metastasis cancer pain who received opioid naive therapy.
Supraventricular Tachycardia Induced by Cisplatin in a Patient with Breast Cancer: A Case Report
Authors: Laksono Sidhi , Kusharsamita Hillary
Published: June 2024

Introduction: Cisplatin is one of the most extensively used chemotherapeutic agents for treating many malignancies. Cisplatin chemotherapy, on the other hand, is linked to cardiotoxicity, which may vary from silent arrhythmias to heart failure to sudden cardiac death. In this article, we describe a case of supraventricular tachycardia induced by cisplatin in a breast cancer patient. Case Presentation: Our patient had no history of heart disease and had SVT during cisplatin administration. This condition resolved when the infusion was stopped and amiodarone was administered intravenously. The electrolyte levels were within the usual range. No abnormalities were detected on her echocardiography imaging. Primary cardiotoxicity from cisplatin was subsequently determined to be this patient's root cause of SVT. The patient also had an excellent response to the subsequent cycles of treatment. Conclusions: It is important to note that cisplatin therapy is associated with cardiac toxicity. Arrhythmias such as SVT have been associated with chemotherapy drugs. Hence the ECG has to be closely monitored during cisplatin administration. In addition, An ECG and echocardiogram should be done regularly to rule out the possibility of a secondary form of chemotherapy-induced arrhythmia.
Epidemiological Characteristics and 3-year Overall Survival Outcome of Nasopharyngeal Cancer in Central Java: A Single Institution Retrospective Study
Authors: Liemiyah Rikha , Ruspita Dian Ayu , Naftali Zulfikar , Muyassaroh Muyassaroh , Farokah Farokah
Published: June 2024

Background: Nasopharyngeal cancer (NPC) has a high incidence and mortality rate in Indonesia, indicating poor survival outcomes. We aimed to evaluate the survival rate of NPC patients and the influence of specific underlying epidemiological characteristics on the overall survival (OS) rate of NPC patients. Methods: We reviewed the medical data from Dr. Kariadi General Hospital's clinical registry system for all newly diagnosed NPC patients between January and December 2018. We retrieved NPC patients' medical record data that met our inclusion/exclusion criteria. The overall survival rate (OS) was estimated using the Kaplan-Meier method. Between-group stratified three-year OS comparisons were conducted using weighted log-rank tests. All statistical analysis was performed in R statistical software. Results: A total of 50  NPC patients were included in the study. Majority of NPC patients were diagnosed in younger age group (58.0%). Male NPC patients dominated this study (74.0%). NPC patients were mostly diagnosed at the advanced stage (76.0%). Nonkeratinizing histology types were frequently found in the study (82.0%). NPC patients achieved a desirable better performance status (78.0%) and had no comorbidities (74.0%). Most NPC patients demonstrated a complete response to therapy (58.0%). The mean follow-up was 26.36 ± 9.5 months and drop-out rate was 18.0%. The three-year OS was 60.8%. Age, sex, stage, histological classification, performance status, comorbidity, therapy response, and therapy drop-out stratified OS did not statistically differ among NPC patients. Conclusions: We found a satisfactory NPC three-year OS. The underlying epidemiological characteristics did not significantly influence the NPC patients' three-year OS.
High CD90 Expression is A Predictor of Axillary Nodal Metastasis in Breast Carcinoma
Authors: Sriwidyani Ni Putu , Dewi I Gusti Ayu Sri Mahendra , Wetan Ni Gusti Ayu Agung Manik Yuniawaty
Published: June 2024

Background: Metastasis is the most common cause of death in breast cancer and nodal metastasis is one of the most important predictive factors for distance metastasis. One of the intrinsic properties of cancer cells is that they resemble stem cells which are capable of self-renewal, resistance to chemotherapy and radiation, and metastasis. CD90 is a stem cell marker found in several malignancies, including breast carcinoma. The objective of this study was to prove that CD90 can predict the occurrence of axillary nodal metastasis in breast carcinoma. Methods: The study design was a case-control study. The subjects of this study were breast cancer patients at Prof. Dr. I. G. N. G. Ngoerah Hospital who underwent mastectomy and axillary lymphadenectomy in the year 2019. CD90 immunohistochemistry was performed and its association with metastasis, along with various clinicopathological markers, was assessed with chi-square and logistic regression tests with a significance level determined at α=0.05. Results: There were 25 cases of breast carcinoma with axillary nodal metastasis and 25 cases without metastasis. There was a significant relationship between high CD90 expression and the occurrence of nodal metastasis (p=0.010). There was no relationship between patient age, histologic grade, histologic subtype, molecular subtype, and T-stage with axillary nodal metastasis. Breast carcinoma patients with high CD90 expression have a 7.25 times higher nodal metastasis risk compared to patients with low CD90 expression. Conclusion: High CD90 expression could predict axillary nodal metastasis in breast carcinoma.
Sinonasal Schwannoma and Progressive Nasal Obstruction
Authors: Fakhriani Rizka , Herdini Camelia , Yudistira Danu
Published: June 2024

IIntroduction: Schwannomas, are non-malignant tumors with well-defined encapsulation and gradual growth patterns. These tumors consist of Schwann cells, which originate from the neural crest. The prevalence of schwannoma cases in the head and neck region ranges from approximately 25% to 45%. However, in the sinus cavity, the occurrence is only 4%. Case Presentation: In this study, we provide a clinical case with a 25-year-old female patient with rhinorrhoea symptoms, recurrent epistaxis, and a decreased sense of smell. The patient had a progressive obstruction in the right nasal cavity over one year. A biopsy and computed tomography (CT) scan identified a schwannoma and soft tissue density lesions in the right maxillary ethmoid sinuses and left septal deviation. The confirmation of schwannoma diagnosis is also achieved through histopathological examination. The tumor was surgically excised from the patient's body utilizing lateral rhinotomy and an extirpation technique under general anesthesia. The patient had positive outcomes during the follow-up; the patient revealed the absence of symptoms and no evidence of disease recurrence. Conclusions: Lateral rhinotomy with extirpation methods represents an effective option for managing sinonasal schwannoma due to its ability to access challenging anatomical regions and facilitate the sensitive excision of tumors.
Imaging Profile of Intracranial Tumors at Dr. Zainoel Abidin Regional General Hospital Banda Aceh
Authors: Bintang Khairunnisa Setia , Novirianthy Rima , Hidayaturrahmi Hidayaturrahmi
Published: June 2024

Background: Brain tumors are divided into two, primary and secondary brain tumors. Primary brain tumors are brain tumors that originate from the brain cells themselves. Meanwhile, secondary brain tumors are tumors that metastasize from tumors located in other parts of the body. Intracranial tumors require imaging modalities to make a diagnosis. Imaging examinations can reveal the type of tumor, location of the tumor, number of lesions, and some radiological features. However, information on imaging examination data of intracranial tumor patients is still limited, especially in Aceh, Indonesia. This study aims to determine the imaging profile of intracranial tumor patients at Dr Zainoel Abidin Regional General Hospital Banda Aceh. Methods: This study design was retrospective descriptive quantitative with the total sampling method. This study was conducted by observing all medical records of intracranial tumor patients recorded from January to December 2022 at Dr. Zainoel Abidin Regional General Hospital Banda Aceh. Results: A total of 88.5% (n=92) of the 104 registered cases were primary intracranial tumors. The most common patient profile was found to be in the range of 46-55 years (25%) and the majority was female (64.4%). The most common type of imaging used was contrast computed tomography (CT)-scan (38.5%), the most common location was supratentorial (74%), the most number of lesions was solitary (83.7%), the most common radiological picture was perifocal edema (66.3%), and the least radiological picture was communicating hydrocephalus (1.9%) and meningeal enhancement (1.9%). Conclusions:  There were more patients with primary intracranial tumors than with secondary intracranial tumors. CT scan was the most used imaging to diagnose intracranial tumors. The most intracranial tumors are supratentorial and solitary lesions with perifocal edema as common radiology features. dalities
The Good Quality of Life of Breast Carcinoma with Aggressive Metastasis to Multilevel Vertebrae: A Case Report
Authors: Mannagalli Yusuf , Kirana Ignatia Rosalia , Niatazya Arindita , Utami Lusyhandri Wiga , Pratiwi Dwirani Rosmala
Published: June 2024

Introduction: Bone is one of the most common metastase sites in breast cancer after lung and liver. Spinal involvement is regarded as an aggressive form of bone metastases due to the risk of neurological dysfunction and paralysis resulting in pain and disability. Therefore, the presence of spinal metastases in breast cancer usually worsens the quality of life (QoL) of patients. This is a persisting challenge in palliative care which aims to improve QoL and provide pain relief. In this case, we reported a 56-year-old female with end-stage breast cancer and extensive spinal involvement who had good QoL based on subjective and objective assessment. Case Presentation: A 56-year-old patient complained of pain in the left breast and back. Physical, imaging, and histopathology examination concluded that the patient suffered from stage IV breast cancer spreading to cervical and lumbal vertebrae, however, the patient reported minimal disturbances in daily activity despite the pain. Objective assessment of quality of life was done using EORTC QLQ-C30, QLQ-BM22, and QLQ-BR23, which revealed a high level of global health status exceeding average breast cancer patients. The high QoL observed in our patient could be attributed to effective symptom management, strong social support, and resilience in coping with the challenges of breast cancer. Conclusions: Continuous psychosocial support, effective symptom management, and strengthening individual resilience have the potential to improve the quality of life in breast cancer patients with spinal metastases.
Synergistic Cytotoxicity of 5-Fluorouracil and Epigallocatechin-3-Gallate on Colorectal Cancer Stem Cell
Authors: Ibrahim Sugeng , Riwanto Ignatius , Suharti Catharina , Putra Agung , Budijitno Selamat
Published: June 2024

Background: Colorectal cancer stem cells (CR-CSCs) derived from the HCT-116 cell line established human colon carcinoma cell line, validated with CD44+/CD133+. The study investigates the synergistic effects of combining epigallocatechin gallate (EGCG) with 5-fluorouracil (5-FU) on CR-CSCs through comprehensive cytotoxicity assessments, aiming to enhance therapeutic outcomes. EGCG is a polyphenol with anti-cancer activity in green tea. Previous studies have reported that the anti-cancer activity of EGCG involves inhibition of proliferation and induction of apoptosis thereby reducing recurrence by as much as 51.6% in patients with colorectal adenoma after polypectomy. The significance lies in optimizing treatment strategies by understanding the potential synergies between conventional chemotherapeutic agents and natural compounds. Given 5-FU's status as a cornerstone in CR-CSCs chemotherapy and EGCG's emergence as a promising natural compound, the study delves into their individual and combined cytotoxicity profiles. Methods: The single and combination assay aimed to determine the cytotoxicity of EGCG and 5-FU, including establishing the half inhibitory concentration (IC50) and combination index (CI) values. CR-CSCs colonies were disassociated, counted, and cultured in 96-well plates. Test solutions of varying concentrations were applied, and subsequent steps involved incubation, media removal, washing, MTT reagent addition, and absorbance measurement. Results: The single cytotoxicity tests established individual IC50 values, revealing 141.26 µM for 5-FU and 464.56 µM for EGCG. Subsequent combination cytotoxicity tests demonstrated a synergistic effect at specific doses, indicated by CI values below 1. Conclusions: These findings highlight the potential for increased cytotoxicity against CR-CSCs when treated with the combination of 5-FU and EGCG.
La literatura infantil y procesos educativos culturales mediante el uso de TICs
Authors: Quezada-Tello Laddy , Ordoñez-Briceño Karla , Astudillo-Zenteno Roberto , Flores-Naranjo Liliana
Published: June 2024

La evolución tecnológica ha transformado las prácticas educativas y culturales, proporcionando nuevos recursos para fortalecer los procesos educativos. Este estudio se enfoca en la intersección entre la literatura infantil, los procesos educativos culturales y el uso de Tecnologías de la Información y Comunicación (TICs). Se investigaron tres proyectos que integran el patrimonio cultural, las TICs y la literatura infantil, explorando cómo estas iniciativas aprovechan las nuevas plataformas para transmitir narraciones basadas en la oralidad.
Los resultados revelan que el proceso educativo cultural desempeña un papel crucial en la preservación del patrimonio, al mismo tiempo que ofrece oportunidades para que estudiantes, profesionales y entidades públicas y privadas desarrollen acciones en beneficio de los niños y la población en general. Estos proyectos demuestran que la combinación de la literatura infantil y las TICs no solo enriquece la experiencia de aprendizaje de los niños, sino que también promueve la participación activa en la preservación y promoción de la cultura.
Este estudio contribuye al campo de las ciencias humanidades al proporcionar una comprensión más profunda de cómo las TICs pueden ser utilizadas de manera efectiva para fomentar la literatura infantil y los procesos educativos culturales. Además, destaca la importancia de aprovechar estas herramientas tecnológicas para involucrar a diversos actores en la promoción del patrimonio cultural y el enriquecimiento del desarrollo educativo.
Closure of Large Tracheocutaneous Fistula With Island Deltopectoral Flap
Authors: Jang Hye-Bin , Kang In Seok , Lee Hyeong Seok , Lee Joon Kyoo
Published: June 2024

Tracheocutaneous fistula (TCF) formation is a complication of long-term tracheostomy use. Surgical closure is necessary for a persistent TCF because this can lead to various complications. Herein, we describe our use of an island deltopectoral (DP) flap to treat a large TCF. A 62-year-old male, who had previously undergone supraglottic partial laryngectomy with laser and radiation therapy, presented with a second recurrence of supraglottic cancer. Supracricoid partial laryngectomy and cricohyoidoepiglottopexy (CHEP) were performed. Afterward, a large TCF measuring about 2.0×2.5 cm developed. The island DP flap facilitated successful TCF closure. There have been no recurrences or complications, and both the reconstruction site and donor site are well-maintained after 25 months of follow-up. The island DP flap can be a useful option for large TCF closure, even for patients who have had previous radiation therapy.
Factors influencing self-management behaviors in persons with lupus nephritis: A cross-sectional study
Authors: Hanrop Sirikarn , Sriyuktasuth Aurawamon , Pongthavornkamol Kanaungnit , Piaseu Noppawan , Chawanasuntorapoj Ratana
Published: June 2024

Background: Patients with lupus nephritis experience disease symptoms and side effects from treatment. Although self-management behaviors are important in patients with this disease, there is limited research on the factors influencing these behaviors.
Objective: This study aimed to examine the factors influencing self-management behaviors in patients with lupus nephritis.
Methods: This cross-sectional study was conducted in 240 patients with lupus nephritis at a university hospital in Thailand between August 2019 and December 2020 using a random sampling method. Data were collected using a demographic and clinical characteristic questionnaire, Self-Management Behavior Questionnaire, Self-efficacy for Managing Chronic Disease: A 6-item Scale, Knowledge about Lupus Nephritis Questionnaire, Family Support Scale, Social Networks in Adult Life Questionnaire, and Memorial Symptom Assessment Scale for Lupus Nephritis. Descriptive statistics and multiple linear regression analyses were employed.
Results: The participants reported a moderate level of self-management behaviors. Multiple regression analyses revealed that disease duration, income, symptoms, self-efficacy, knowledge, family support, social networks, and classes of lupus nephritis significantly explained 21% of the variance in self-management behaviors (R2 = 0.21; F(8,231) = 7.73; p <0.001). Family support (β = 0.32, p <0.001) and symptoms (β = −0.23, p<0.001) were significant determinants of self-management behaviors in patients with lupus nephritis.
Conclusion: The findings provide valuable insight for nurses to better understand the factors influencing self-management behaviors in patients with lupus nephritis. Patients with low family support and high symptom severity may face difficulty in performing self-management behaviors. Nurses should pay more attention to these patients and provide family-based interventions to optimize self-management behaviors in this population.
Nursing students’ lived experiences with using AIDET in patient communication: A qualitative study in the Philippines
Authors: Madayag Rudena A. , Esteron Jeffrey V. , Lozano Dianne Anne A. , Bautista Evangeline C. , Fernandez Zenaida S. , Ramirez Debbie Q.
Published: June 2024

Background: Effective communication is vital in nursing, influencing patient safety, satisfaction, and care quality. The AIDET framework is a proven tool for reducing patient anxiety and enhancing their experience. However, perceptions and experiences of Filipino nursing students with AIDET remain unexplored.
Objective: This study explored Filipino nursing students’ use of AIDET, focusing on benefits, challenges, and improvements.
Methods: A qualitative, interpretive phenomenological approach informed by the philosophy of Martin Heidegger was employed. This 2023 study, conducted at a university in Angeles City, Philippines, explored Filipino nursing students’ experiences with the AIDET communication framework. Thirty participants were purposefully selected to participate in facilitated discussions following a semi-structured interview guide. Thematic content analysis of the transcribed audio recording identified recurring themes in their narratives, focusing on the meanings they ascribed to their experiences using AIDET.
Results: Four themes emerged: (a) Streamlined nurse-patient interaction (organizes communication, rapport building,  alleviate anxiety, acknowledgment, and empowerment as sub-themes),  (b) Enhances patient-centered care (empathy and compassion, improved patient experience as sub-topics), (c) Challenges with specific patient populations (patient preferences, language barrier, patient condition, acknowledgment of cultural differences as sub-themes), and (d) AIDET in nursing education strengthening application through practice, optimizing frequency and timing, promoting deeper understanding, enhancing feedback mechanism) as student nurses’ recommendations.
Conclusion: Early integration of AIDET in nursing education is essential for student nurses to enhance communication, improve patient satisfaction, and deliver patient-centered care, equipping them with valuable communication skills.
Green intellectual capital: The secret ingredient for organizational competitive advantage in the nursing profession—a cross-sectional study from Egypt
Authors: Atalla Amal Diab Ghanem , Elbassal Nariman Ahmed Mohamed Mostafa , Kandil‬‏ Faten Shawky , El-Ashry Ayman Mohamed , Mohamed Ishraga Abdelgadir Ibrahim , Behilak Sahar Elsayed Gaber , Elseesy Naglaa Abdelaziz Mahmoud
Published: June 2024

Background: In the contemporary healthcare environment, managing human resources expertise is just as imperative as having the supreme amount of working capital. Every business must constantly build its capacity, expertise, and competitive edge by utilizing its intellectual property and experience.

Objective: This study aimed to assess the relationship between green intellectual capital and organizational competitive advantage among nurses.

Methods: The study employed a descriptive correlational design among 350 nurses selected using convenience sampling. Data were collected from March 2023 to June 2023 using the Organizational Competitive Advantage Scale and the Green Intellectual Capital Questionnaire. Data were analyzed using t-test, ANOVA, and Pearson correlation.

Results: Most nurses had a moderate level of green intellectual capital (Mean = 3.60, SD = 0.27). The overall mean score for organizational competitive advantage was moderate (Mean = 3.34, SD = 0.34). The overall score of the green intellectual capital (r = 0.257, p <0.001) and its dimensions—green human capital (r = 0.257, p <0.05), green structure capital (r = 0.257, p <0.001), and green relational capital (r = 0.257, p<0.001)—had significant positive correlations with organizational competitive advantage.

Conclusion: Being eco-friendly has become a determining factor in the organizational competitive advantage. The study highlights the significance of nursing management in establishing partnerships with external entities to share knowledge and advance sustainable healthcare methods. It advocates for assessing organizational environmental performance and its influence on competitive edge through creating metrics, monitoring progress, and utilizing data for decision-making. Healthcare and nurse administrators are advised to set performance benchmarks, track advancements, and integrate eco-friendly strategies to bolster the hospital’s competitiveness in the market.
Nurses-Led Municipal Leadership and Governance Program: Experiences of Local Chief Executives in Central Visayas, Philippines
Authors: Palompon Daisy R. , Naranjo Michele A. , Abalos Evalyn , Omus Nelner , Flores Philip Jerome A.
Published: June 2024

Background: The strategic response of nurses in addressing health inequities in marginal sectors led to the conduct of a health leadership governance training program for local chief executives.
Objective: This study aimed to explore and provide a description of the experiences of local chief executives (LCEs) or mayors who participated in the nurse-initiated health training named Municipal Leadership and Governance Program (MLGP).
Methods: A qualitative descriptive design was used through key informant interviews of fifteen mayors or local chief executives (LCE) in the provinces of Bohol and Negros Oriental, Philippines. Data were collected from 16 to 20 November 2022 and analyzed using a thematic approach.
Results: The findings generated six themes: a) Leadership capacitation promoting transformative experience, b) Pandemic and program-induced limitations in the training implementation, c) Personal leadership motivation, d) Experiential learning promoting learning as applied in real-world situations, e) Celebrating leadership transformation, and f) 3R’s of MLGP: revisit, review, recommend.
Conclusion: The realizations of the training participants provided valuable implications for the quality of training offered by nurse leaders who advocated the MLGP implementation. It served as a proactive and responsive approach to the health leadership capacitation of mayors. It guided them in their personal realizations that inspired them to apply what they had learned and enabled them to effect experiences of personal to institutional transformation.
Gen Z and Millennials: Contrasts in Reading Behavior and Readerly Identity
Authors: Noorda Rachel , Berens Kathi Inman
Published: June 2024

Identifying as a reader or not-a-reader is about more than reading behaviors. Reading is a social practice and a form of cultural, and readerly, capital ( Driscoll 2016 ), which is why “the reading practices young people engage in are part of their broader social and cultural participation and, consequently, part of a broader project of identity formation” ( Sellers 2019 ). This article presents nationally representative survey data (n=2075) of Gen Z and millennials residing in the U.S. who don’t identify as readers (“not-a-readers”) to examine the complexity of bookish and non-bookish identity and its connection to reading and media consumption habits. Additionally, this article examines other bookish and non-bookish reading behaviors and identities of Gen Z and millennials to contextualize readers and not-a-readers. We surmise that people are more likely to decline identifying as a reader if the reading they do is not part of their social communities.

Our nomenclature: Not-a-readers is about identity; non-reader is about behavior.

Surprisingly, not-a-readers are still readers and actually read more than the general survey population when it comes to print books. They visit libraries at rates close to those of readers. People who identify as readers, writers, and fans share some of the same interests in story, but their behaviors are quite different depending upon whether that identity is connected or not to bookish communities. This article addresses larger questions about 1) what counts as reading, and how reports about reading that center book reading miss emergent swaths of activity; 2) the tension between readerly identity and reader behavior; 3) how not-a-readers discover books; 4) how other identities such as writers, fans, and “pirates” intersect with readerly identity.
HIZ TEMELLİ ANTRENMANLARDA KULLANIM AMACIYLA GELİŞTİRİLEN BİR LİNEER TRANSDÜSERİN GÜVENİRLİĞİ VE GEÇERLİĞİ
Authors: İnce İzzet
Published: June 2024

Hız temelli kuvvet antrenmanları, son yıllarda büyük ilgi gören bir yaklaşım olarak dikkat çekmektedir. Bu yöntemin uygulanmasında en sık tercih edilen cihazlar lineer transdüserlerdir. Bu araştırmada, donanımı ve yazılımı yazar tarafından geliştirilen bir lineer transdüserin güvenirlik ve geçerliğinin değerlendirilmesi amaçlanmıştır. Optik kodlayıcı, bluetooth ve Wi-Fi modülü ile donatılmış bir mikrodenetleyiciden oluşan bu lineer transdüser, kriter cihaz Tendo Power Analyzer ile karşılaştırılmıştır. Araştırmaya 13 halterci gönüllü olarak katılmıştır. Silkme çekişi esnasında farklı yüklerle (%40, %60, %90 ve %110 1TM) gerçekleştirilen eş zamanlı maksimum hız ölçümleri alınarak geçerlik değerlendirilmiş; bir hafta arayla, aynı saatte ve aynı test prosedürleri uygulanarak test-tekrar test güvenirliği incelenmiştir. Güvenirlik analizi için sınıf içi korelasyon katsayısı (ICC), varyasyon katsayısı (CV), ölçümlerin standart hatası (SEM) ve minimum tespit edilebilir değişim (MDC) hesaplanmıştır. Geçerlik, eşli örneklemler t-testi, regresyon analizi ve Bland-Altman analizi kullanılarak değerlendirilmiştir. ICC değerleri 0.85 ile 0.96 arasında değişmiş, CV değerleri %1.62 ile %4.12 arasında bulunmuştur. SEM değerleri 0.045 m·s⁻¹ ile 0.084 m·s⁻¹ arasında hesaplanmış, MDC değerleri ise 0.137 m·s⁻¹ ile 0.236 m·s⁻¹ arasında değişmiştir. Bland-Altman grafiklerine göre, farklar rastgele bir dağılım göstermiş ve sistematik (sabit veya oransal) bir sapma gözlenmemiştir. Regresyon analizleri sonucunda da sabit veya oransal sapma tespit edilmemiştir. Analiz sonuçları, geliştirilen cihazın silkme çekişi esnasında farklı yüklerle gerçekleştirilen maksimal hız ölçümlerinde güvenilir ve geçerli olduğunu ortaya koymaktadır.