bluuebunny/crossref_metadata_2025 huggingface dataset:
Determining Information Security Threats for an IoT-Based Energy Internet by Adopting Software Engineering and Risk Management Approaches
Authors: Chen Yu-Tso , Huang Chuang-Chiao
Published: September 2019

This paper introduces an information security threat modeling (ISTM) scheme, which leverages the strengths of software engineering and risk management approaches, called I-SERM. The proposed I-SERM scheme effectively and efficiently prioritizes information security threats for IT systems that utilize a large number of sensors, such as Internet of Things (IoT)-based energy systems. I-SERM operations include determining functional components, identifying associated threat types, analyzing threat items, and prioritizing key threats with the use of software engineering tools such as product flow diagrams, use case diagrams, and data flow diagrams. By simultaneously referring to a proposed STRIDE+p matrix and a defined threat breakdown structure with reference score (TBS+r) scheme, the I-SERM approach enables systematic ISTM. To demonstrate the usability of I-SERM, this study presents a practical case aimed at electricity load balancing on a smart grid. In brief, this study indicates a substantive research direction that combines the advantages of software engineering and risk management into a systematic ISTM process. In addition, the demonstration of I-SERM in practice provides a valuable and practical reference for I-SERM application, and contributes to research in the field of information security designs for IoT-based Energy Internet systems.
Surface Pre-Reacted Glass Filler Contributes to Tertiary Dentin Formation through a Mechanism Different Than That of Hydraulic Calcium-Silicate Cement
Authors: Okamoto Motoki , Ali Manahil , Komichi Shungo , Watanabe Masakatsu , Huang Hailing , Ito Yuki , Miura Jiro , Hirose Yujiro , Mizuhira Manabu , Takahashi Yusuke , Okuzaki Daisuke , Kawabata Shigetada , Imazato Satoshi , Hayashi Mikako
Published: September 2019

The induction of tissue mineralization and the mechanism by which surface pre-reacted glass-ionomer (S-PRG) cement influences pulpal healing remain unclear. We evaluated S-PRG cement-induced tertiary dentin formation in vivo, and its effect on the pulp cell healing process in vitro. Induced tertiary dentin formation was evaluated with micro-computed tomography (μCT) and scanning electron microscopy (SEM). The distribution of elements from the S-PRG cement in pulpal tissue was confirmed by micro-X-ray fluorescence (μXRF). The effects of S-PRG cement on cytotoxicity, proliferation, formation of mineralized nodules, and gene expression in human dental pulp stem cells (hDPSCs) were assessed in vitro. μCT and SEM revealed that S-PRG induced tertiary dentin formation with similar characteristics to that induced by hydraulic calcium-silicate cement (ProRoot mineral trioxide aggregate (MTA)). μXRF showed Sr and Si ion transfer into pulpal tissue from S-PRG cement. Notably, S-PRG cement and MTA showed similar biocompatibility. A co-culture of hDPSCs and S-PRG discs promoted mineralized nodule formation on surrounding cells. Additionally, S-PRG cement regulated the expression of genes related to osteo/dentinogenic differentiation. MTA and S-PRG regulated gene expression in hDPSCs, but the patterns of regulation differed. S-PRG cement upregulated CXCL-12 and TGF-β1 gene expression. These findings showed that S-PRG and MTA exhibit similar effects on dental pulp through different mechanisms.
Probiotics for the Prophylaxis of Migraine: A Systematic Review of Randomized Placebo Controlled Trials
Authors: Naghibi Malwina M. , Day Richard , Stone Samantha , Harper Ashton
Published: September 2019

Migraine is a common and disabling neurological condition with a complex etiology. Recent advances in the understanding of the gut microbiome have shown the role of gut micro-organisms in disease outcomes for distant organs—including the brain. Interventions targeting the gut microbiome have been shown to be effective in multiple neurological diagnoses, but there is little research into the role of the microbiome in migraine. This systematic review seeks to assess the current research landscape of randomized placebo controlled trials utilizing probiotic interventions as migraine prophylaxis. Searches were conducted of scientific databases including PubMed, MEDLINE, and the Cochrane Library, following PRISMA guidelines. Of 68 screened studies, 2 were eligible for analysis. Due to methodological differences, meta-analysis was not possible. Qualitative comparison of the studies demonstrated a dichotomy of results—one trial reported no significant change in migraine frequency and intensity, while the second trial reported highly significant improvements. No clear ‘gold standard’ currently exists for microbiome research, let alone for migraine-related microbiome research. The heterogeneity of outcome measures used in the two trials included in this systematic review shows the need for a standardization of outcome measures, therefore a series of recommendations for future probiotic–migraine research are included.
Colistin Heteroresistance in Klebsiella Pneumoniae Isolates and Diverse Mutations of PmrAB and PhoPQ in Resistant Subpopulations
Authors: Cheong Hae Suk , Kim So Yeon , Wi Yu Mi , Peck Kyong Ran , Ko Kwan Soo
Published: September 2019

Heteroresistance may pose a threat to the prognosis of patients following colistin treatment. We investigated colistin heteroresistance in Klebsiella pneumoniae isolates from South Korea. Among 252 K. pneumoniae blood isolates, 231 were susceptible to polymyxins. Heteroresistance to colistin was determined using population analysis profiles, disk diffusion assays, and E-test strip tests for the susceptible isolates. As a result, we identified three colistin-heteroresistant K. pneumoniae isolates belonging to separate clones (ST11, ST461, and ST3217) by multilocus sequence typing analysis. Two colistin-resistant subpopulations were selected from each heteroresistant isolate in either disk diffusion testing or E-testing. Two resistant subpopulations from the same isolate exhibited different amino acid substitutions in the two-component regulatory systems PmrAB and PhoPQ. An in vitro time–kill assay showed that meropenem combined with colistin had a 1× minimum inhibitory concentration bactericidal effect against a multidrug-resistant, colistin-heteroresistant isolate.
Evolution of the Internal Structure of Short-Period Cr/V Multilayers with Different Vanadium Layers Thicknesses
Authors: Qi Runze , Huang Qiushi , Fei Jiani , Kozhevnikov Igor V. , Liu Yang , Li Pin , Zhang Zhong , Wang Zhanshan
Published: September 2019

Cr/V multilayer mirrors are suitable for applications in the “water window” spectral ranges. To study factors influencing the internal microstructure of Cr/V multilayers, multilayers with different vanadium layers thicknesses varying from 0.6 nm to 4.0 nm, and a fixed thickness (1.3 nm) of chromium layers, were fabricated and characterized with a set of experimental techniques. The average interface width characterizing a cumulative effect of different structure irregularities was demonstrated to exhibit non-monotonous dependence on the V layer thickness and achieve a minimal value of 0.31 nm when the thickness of the V layers was 1.2 nm. The discontinuous growth of very thin V films increased in roughness as the thickness of V layers decreased. The columnar growth of the polycrystalline grains in both materials became more pronounced with increasing thickness, resulting in a continuous increase in the interface width to a maximum of 0.9 nm for a 4 nm thickness of the V layer.
Residual Gas Adsorption and Desorption in the Field Emission of Titanium-Coated Carbon Nanotubes
Authors: Zhang Huzhong , Li Detian , Wurz Peter , Cheng Yongjun , Wang Yongjun , Wang Chengxiang , Sun Jian , Li Gang , Fausch Rico Georgio
Published: September 2019

Titanium (Ti)-coated multiwall carbon nanotubes (CNTs) emitters based on the magnetron sputtering process are demonstrated, and the influences of modification to CNTs on the residual gas adsorption, gas desorption, and their field emission characteristic are discussed. Experimental results show that Ti nanoparticles are easily adsorbed on the surface of CNTs due to the “defects” produced by Ar+ irradiation pretreatment. X-ray photoelectron spectroscopy (XPS) characterization showed that Ti nanoparticles contribute to the adsorption of ambient molecules by changing the chemical bonding between C, Ti, and O. Field emission of CNTs coated with Ti nanoparticles agree well with the Fowler–Nordheim theory. The deviation of emission current under constant voltage is 6.3% and 8.6% for Ti-CNTs and pristine CNTs, respectively. The mass spectrometry analysis illustrated that Ti-coated CNTs have a better adsorption capacity at room temperature, as well as a lower outgassing effect than pristine CNTs after degassing in the process of field emission.
Utilization of Recycled Liquid Crystal Display (LCD) Panel Waste in Concrete
Authors: Góra Jacek , Franus Małgorzata , Barnat-Hunek Danuta , Franus Wojciech
Published: September 2019

The paper presents the possibility of using the liquid crystal display (LCD) waste as a partial substitute of fine aggregate. Concretes with two types of cement, CEM I 42.5 R and CEM II/B-S 42.5 N, with and without LCD addition, were investigated. The properties that influence the structures exposed to severe environments were examined. The results and analyses pertaining to their micro-structure, including interfacial transition zone (ITZ), were presented as well. All concretes exhibited good freeze–thaw (F–T) resistance after 150 F–T cycles. The water-tightness was established as 0.8 MPa. All concretes both with and without LCD achieved the same class C50/60.
The Effects of Heat Straightening Temperature on the Microstructure and Properties of 7N01 Aluminum Alloy
Authors: Li Shuai , Dong Honggang , Shi Lei , Wang Xingxing , Liu Zhongying , Shangguan Linjian , Tian Yusong
Published: September 2019

The 7N01 aluminum alloys are always used in vehicles, but heat treatment can deteriorate mechanical properties and corrosion resistance, which limits its utilization. In this paper, the influences of the temperature of heat straightening on the corrosion behavior and mechanical properties of 7N01 aluminum alloy are investigated. Most of the initial Guinier Preston (GP) zones dissolve into the matrix during heat treatment process, while the grain boundary precipitates have no obvious change. The precipitates of the samples after heat treatment mainly consist of high density GP zones due to the natural aging effect, which result in the recovery of micro-hardness. Although heat treatment decreases the mechanical properties of 7N01 aluminum alloy, there is no obvious difference in mechanical properties of the specimens after different heat treatment conditions. The corrosion resistance of heat treatment samples decreases significantly compared with the base metal, which is attributed to enhancing the difference between the potential of the alloy matrix and the grain boundary.
Biomimetic Polymer-Based Engineered Scaffolds for Improved Stem Cell Function
Authors: Patel Dinesh K. , Lim Ki-Taek
Published: September 2019

Scaffolds are considered promising materials for tissue engineering applications due to their unique physiochemical properties. The high porosity and adequate mechanical properties of the scaffolds facilitate greater cell adhesion, proliferation, and differentiation. Stem cells are frequently applied in tissue engineering applications due to their excellent potential. It has been noted that cell functions are profoundly affected by the nature of the extracellular matrix (ECM). Naturally derived ECM contains the bioactive motif that also influences the immune response of the organism. The properties of polymer scaffolds mean they can resemble the native ECM and can regulate cellular responses. Various techniques such as electrospinning and 3D printing, among others, are frequently used to fabricate polymer scaffolds, and their cellular responses are different with each technique. Furthermore, enhanced cell viability, as well as the differentiation ability of stem cells on the surface of scaffolds, opens a fascinating approach to the formation of ECM-like environments for tissue engineering applications.
System of Energy-Saving Optimal Control of Metal Heating Process in Heat Treatment Furnaces of Rolling Mills
Authors: Andreev Sergey
Published: September 2019

Heat-treatment furnaces for workpiece pre-rolling heating are heating plants of the transition type where sheet slabs with various characteristics are simultaneously heated. The heat treatment furnace performance is directly connected with the efficient operation of the rolling mill process plants. The irregular operation pace of the rolling mill complicates the implementation of energy-saving workpiece pre-rolling heating modes and increases the risk of delivering an insufficiently heated workpiece. This paper proposes the system of controlling the heat mode of the heat-treatment furnace by the criterion of fuel consumption rate minimization and controlling over a real heated state of a sheet slab located at the workpiece pushing from the heat-treatment furnace to the rolling mill. The author uses a simplified mathematical model of workpiece heating intended for defining the energy-saving heating path accounting for the impact of technological and structural constraints in the workpiece heating process. The calculation is conducted in real time and allows obtaining an optimal heating path of each workpiece at the moment of its loading into the heat-treatment furnace. The paper considers the necessity of interaction and the interaction itself of the subsystems performing the key function in the energy-saving operation mode of the heat-treatment furnace at workpiece heating. The author studied the subsystems of forecasting the workpiece heating time on the state of the rolling mill equipment and the geometrical dimensions of the rolled band, control over gaseous fuel burning in the heat-treatment furnace operation space, system of control over the workpiece heating state before pushing from the heat-treatment furnace and forecasting the roll temperature after the treatment of the rolling mill roughing train.
On Locating and Counting Satellite Components Born along the Stability Circle in the Parameter Space for a Family of Jarratt-Like Iterative Methods
Authors: Geum Young Hee , Kim Young Ik
Published: September 2019

This paper is devoted to an analysis on locating and counting satellite components born along the stability circle in the parameter space for a family of Jarratt-like iterative methods. An elementary theory of plane geometric curves is pursued to locate bifurcation points of such satellite components. In addition, the theory of Farey sequence is adopted to count the number of the satellite components as well as to characterize relationships between the bifurcation points. A linear stability theory on local bifurcations is developed based upon a small perturbation about the fixed point of the iterative map with a control parameter. Some properties of fixed and critical points under the Möbius conjugacy map are investigated. Theories and examples on locating and counting bifurcation points of satellite components in the parameter space are presented to analyze the bifurcation behavior underlying the dynamics behind the iterative map.
Transformation of Some Lambert Series and Cotangent Sums
Authors: Kim Namhoon
Published: September 2019

By considering a contour integral of a cotangent sum, we give a simple derivation of a transformation formula of the series A ( τ , s ) = ∑ n = 1 ∞ σ s − 1 ( n ) e 2 π i n τ for complex s under the action of the modular group on τ in the upper half plane. Some special cases directly give expressions of generalized Dedekind sums as cotangent sums.
Inertial Method for Bilevel Variational Inequality Problems with Fixed Point and Minimizer Point Constraints
Authors: Yimer Seifu Endris , Kumam Poom , Gebrie Anteneh Getachew , Wangkeeree Rabian
Published: September 2019

In this paper, we introduce an iterative scheme with inertial effect using Mann iterative scheme and gradient-projection for solving the bilevel variational inequality problem over the intersection of the set of common fixed points of a finite number of nonexpansive mappings and the set of solution points of the constrained optimization problem. Under some mild conditions we obtain strong convergence of the proposed algorithm. Two examples of the proposed bilevel variational inequality problem are also shown through numerical results.
The Applications of Lattice Light-Sheet Microscopy for Functional Volumetric Imaging of Hippocampal Neurons in a Three-Dimensional Culture System
Authors: Chen Chin-Yi , Liu Yen-Ting , Lu Chieh-Han , Lee Po-Yi , Tsai Yun-Chi , Wu Jyun-Sian , Chen Peilin , Chen Bi-Chang
Published: September 2019

The characterization of individual cells in three-dimensions (3D) with very high spatiotemporal resolution is crucial for the development of organs-on-chips, in which 3D cell cultures are integrated with microfluidic systems. In this study, we report the applications of lattice light-sheet microscopy (LLSM) for monitoring neuronal activity in three-dimensional cell culture. We first established a 3D environment for culturing primary hippocampal neurons by applying a scaffold-based 3D tissue engineering technique. Fully differentiated and mature hippocampal neurons were observed in our system. With LLSM, we were able to monitor the behavior of individual cells in a 3D cell culture, which was very difficult under a conventional microscope due to strong light scattering from thick samples. We demonstrated that our system could study the membrane voltage and intracellular calcium dynamics at subcellular resolution in 3D under both chemical and electrical stimulation. From the volumetric images, it was found that the voltage indicators mainly resided in the cytosol instead of the membrane, which cannot be distinguished using conventional microscopy. Neuronal volumetric images were sheet scanned along the axial direction and recorded at a laser exposure of 6 ms, which covered an area up to 4800 μm2, with an image pixel size of 0.102 μm. When we analyzed the time-lapse volumetric images, we could quantify the voltage responses in different neurites in 3D extensions.
Effects on Gene Transcription Profile and Fatty Acid Composition by Genetic Modification of Mevalonate Diphosphate Decarboxylase MVD/Erg19 in Aspergillus Oryzae
Authors: Hu Zhihong , Huang Hui , Sun Yunlong , Niu Yali , Xu Wangzishuai , Liu Qicong , Zhang Zhe , Jiang Chunmiao , Li Yongkai , Zeng Bin
Published: September 2019

Mevalonate diphosphate decarboxylase MVD/Erg19 is required for ergosterol biosynthesis, growth, sporulation, and stress tolerance in Aspergillus oryzae. In this study, RNA-seq was used to analyze the gene transcription profile in AoErg19 overexpression (OE) and RNAi strains. There were 256 and 74 differentially expressed genes (DEGs) in AoErg19 OE and RNAi strains, respectively, compared with the control strain (CK). The most common DEGs were transport- and metabolism-related genes. Only 22 DEGs were obtained that were regulated in both OE and RNAi strains. The transcriptomic comparison between CK and AoErg19 overexpression strain (CK vs. OE), and between CK and AoErg19 RNAi strain (CK vs. RNAi) revealed that the greatest difference existed in the number of genes belonging to the cytochrome P450 family; 12 were found in CK vs. OE, whereas 1 was found in CK vs. RNAi. The expression patterns of lipid biosynthesis and metabolism related genes were altered in OE and RNAi strains, either by gene induction or suppression. Moreover, the total fatty acid content in the RNAi strain was 12.1% greater than the control strain, but no difference in total acid content was found between the overexpression strain and the control strain. Therefore, this study highlights the gene expression regulation within mevalonate (MVA), ergosterol biosynthesis, and fatty acid biosynthesis pathways.
Evaporation Rate of Colloidal Droplets of Jet Fuel and Carbon-Based Nanoparticles: Effect of Thermal Conductivity
Authors: Aboalhamayie Ahmed , Festa Luigi , Ghamari Mohsen
Published: September 2019

Adding nanoparticles to liquid fuel is known to promote its combustion characteristics through improving several thermo-physical properties. This study investigates the effects of adding carbon nanoparticles on thermal conductivity and evaporation rate of liquid jet fuel. Multi-walled carbon nanotubes, activated carbon nanoparticles, and graphene nanoplatelets were added to jet fuel at different concentrations to prepare colloidal suspensions. Thermal conductivity is determined by passing known amounts of heat through a very thin layer of fuel and measuring temperature difference across its thickness. A fiber-supported droplet technique is also used to evaluate evaporation rate due to force convection of a hot inert gas. It is observed that both thermal conductivity and evaporation rate increase as a result of nanoparticle addition. Since there is no radiation heat transfer mechanism, the increase in evaporation rate is concluded to be only due to enhanced thermal conductivity.
Application of CuxO-FeyOz Nanocatalysts in Ethynylation of Formaldehyde
Authors: Li Haitao , Ban Lijun , Niu Zhuzhu , Huang Xin , Meng Pingfan , Han Xudong , Zhang Yin , Zhang Hongxi , Zhao Yongxiang
Published: September 2019

Composite nanomaterials have been widely used in catalysis because of their attractive properties and various functions. Among them, the preparation of composite nanomaterials by redox has attracted much attention. In this work, pure Cu2O was prepared by liquid phase reduction with Cu(NO3)2 as the copper source, NaOH as a precipitator, and sodium ascorbate as the reductant. With Fe(NO3)3 as the iron source and solid-state phase reaction between Fe3+ and Cu2O, CuxO-FeyOz nanocatalysts with different Fe/Cu ratios were prepared. The effects of the Fe/Cu ratio on the structure of CuxO-FeyOz nanocatalysts were studied by means of X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), ultraviolet confocal Raman (Raman), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS, XAES), and hydrogen temperature-programmed reduction (H2-TPR). Furthermore, the structure–activity relationship between the structure of CuxO-FeyOz nanocatalysts and the performance of formaldehyde ethynylation was discussed. The results show that Fe3+ deposited preferentially on the edges and corners of the Cu2O surface, and a redox reaction between Fe3+ and Cu+ occurred, forming CuxO-FeyOz nanoparticles containing Cu+, Cu2+, Fe2+, and Fe3+. With the increase of the Fe/Cu ratio, the content of CuxO-FeyOz increased. When the Fe/Cu ratio reached 0.8, a core–shell structure with Cu2O inside and a CuxO-FeyOz coating on the outside was formed. Because of the large physical surface area and the heterogeneous structure formed by CuxO-FeyOz, the formation of nonactive Cu metal is inhibited, and the most active species of Cu+ are exposed on the surface, showing the best formaldehyde ethynylation activity.
Anti-Obesity Effects of the Flower of Prunus persica in High-Fat Diet-Induced Obese Mice
Authors: Song Jungbin , Kim Young-Sik , Kim Linae , Park Hyo Jin , Lee Donghun , Kim Hocheol
Published: September 2019

Prunus persica (L.) Batsch is a deciduous fruit tree cultivated worldwide. The flower of P. persica (PPF), commonly called the peach blossom, is currently consumed as a tea for weight loss in East Asia; however, its anti-obesity effects have yet to be demonstrated in vitro or in vivo. Since PPF is rich in phytochemicals with anti-obesity properties, we aimed to investigate the effects of PPF on obesity and its underlying mechanism using a diet-induced obesity model. Male C57BL/6 mice were fed either normal diet, high-fat diet (HFD), or HFD containing 0.2% or 0.6% PPF water extract for 8 weeks. PPF significantly reduced body weight, abdominal fat mass, serum glucose, alanine transaminase and aspartate aminotransferase levels, and liver and spleen weights compared to the HFD control group. Real-time quantitative polymerase chain reaction analysis revealed that PPF suppressed lipogenic gene expression, including stearoyl-CoA desaturase-1 and -2 and fatty acid synthase, and up-regulated the fatty acid β-oxidation gene, carnitine palmitoyltransferase-1, in the liver. Our results suggest that PPF exerts anti-obesity effects in obese mice and these beneficial effects might be mediated through improved hepatic lipid metabolism by reducing lipogenesis and increasing fatty acid oxidation.
Hypothalamic–Pituitary and Adipose Tissue Responses to the Effect of Resistin in Sheep: The Integration of Leptin and Resistin Signaling Involving a Suppressor of Cytokine Signaling 3 and the Long Form of the Leptin Receptor
Authors: Zieba Dorota Anna , Biernat Weronika , Szczesna Malgorzata , Kirsz Katarzyna , Misztal Tomasz
Published: September 2019

We hypothesized that resistin is engaged in the development of leptin central insensitivity/resistance in sheep, which is a unique animal model to explore reversible leptin resistance. Thirty Polish Longwool ewes, which were ovariectomized with estrogen replacement, were used. Treatments consisted of the intravenous injection of control (saline) or recombinant bovine resistin (rbresistin): control (Control; n = 10), a low dose of rbresistin (R1; 1.0 μg/kg body weight (BW); n = 10), and a high dose of rbresistin (R2; 10.0 μg/kg BW; n = 10). The studies were performed during short-day (SD) and long-day (LD) photoperiods. Leptin and resistin concentrations were determined. Expression levels of a suppressor of cytokine signaling (SOCS)-3 and the long form of the leptin receptor (LeptRb) were determined in selected brain regions, including in the anterior pituitary (AP), hypothalamic arcuate nucleus (ARC), preoptic area (POA), and ventro- and dorsomedial nuclei (VMH/DMH). The results indicate that resistin induced a consistent decrease in LeptRb (except in POA) and an increase in SOCS-3 expression during the LD photoperiod in all selected brain regions. In conclusion, the results demonstrate that the action of resistin appears to be strongly associated with photoperiod-driven changes in the leptin signaling pathway, which may underlie the phenomenon of central leptin resistance.
The Interplay of Diet Quality and Alzheimer’s Disease Genetic Risk Score in Relation to Cognitive Performance Among Urban African Americans
Authors: Hossain Sharmin , Beydoun May A. , Kuczmarski Marie F , Tajuddin Salman , Evans Michele K , Zonderman Alan B
Published: September 2019

We examined the interactive associations of poor diet quality and Alzheimer’s Disease (AD) genetic risk with cognitive performance among 304 African American adults (mean age~57 years) from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study. In this cross-sectional study, selected participants had complete predictors and covariate data with 13 cognitive test scores as outcomes. Healthy Eating Index-2010 (HEI-2010), Dietary Approaches to Stop Hypertension (DASH), and mean adequacy ratio (MAR) were measured. A genetic risk score for AD in HANDLS (hAlzScore) was computed from 12 selected single nucleotide polymorphisms (SNPs). Our key hypotheses were tested using linear regression models. The hAlzScore was directly associated with poor performance in verbal memory (−0.4 ± 0.2, 0.01) and immediate visual memory (0.4 ± 0.2, 0.03) measured in seconds, in women only. The hAlzScore interacted synergistically with poorer diet quality to determine lower cognitive performance on a test of verbal fluency. Among numerous SNP × diet quality interactions for models of cognitive performance as outcomes, only one passed correction for multiple testing, namely verbal fluency. Our results suggest that improved diet quality can potentially modify performance on cognitive tests of verbal fluency among individuals with higher AD genetic risk.
Reproducibility of A Non-Quantitative Food Frequency Questionnaire (62-Item FFQ-6) and PCA-Driven Dietary Pattern Identification in 13–21-Year-Old Females
Authors: Niedzwiedzka Ewa , Wadolowska Lidia , Kowalkowska Joanna
Published: September 2019

The aim of this study was to evaluate the test–retest reproducibility of a non-quantitative food frequency questionnaire (acronym: 62-item FFQ-6) and the possibility of identifying dietary patterns (DPs) in 13–21-year-old females. The study involved 97 females within three age groups: 13–15, 16–18, and 19–21 years, including 31, 38, and 28 subjects, respectively. The questionnaire was completed twice with a two-week interval (test and retest). For the total sample, using a principal component analysis (PCA), two similar PCA-driven DPs (DP1 and DP2) were identified separately from test data and retest data, considering two sets of input variables. 60-item-DP1 and 60-item-DP2 were identified after excluding two items—vegetables and fruits in general—due to including single items of various kinds of vegetables and fruits. After an aggregation of some items of the questionnaire, 25-item-DP1 and 25-item-DP2 were identified. The kappa statistic (test vs. retest) in the total sample averaged at 0.52 (0.32–0.72 for food items), while within age groups, it averaged at 0.41, 0.53, and 0.65, respectively. The percentage of subjects classified into the same food frequency category (test vs. retest) in the total sample averaged at 68% (51%–89% for food items), while within age groups, it averaged at 60%, 68%, and 77%, respectively. The Spearman correlations between dietary pattern scores (test vs. retest) in the total sample were: 0.84 (within age groups 0.83, 0.81, and 0.78, respectively) for 60-item-DP1, 0.68 (within age groups 0.24, 0.79, and 0.76, respectively) for 60-item-DP2, 0.76 (within age groups 0.56, 0.82, and 0.89, respectively) for 25-item-DP1, and 0.48 (within age groups 0.40, 0.57, and 0.53, respectively) for 25-item-DP2 (p < 0.05 for all). In conclusion, the test–retest reproducibility of the 62-item FFQ-6 was good or very good for most food items, with a tendency to be higher in older age groups of females under study. Due to the acceptable-to-good reproducibility of dietary pattern identification, the use of a 62-item FFQ-6 to describe the overall diet of young Polish females can be recommended.
Changing Sodium Knowledge, Attitudes and Intended Behaviours Using Web-Based Dietary Assessment Tools: A Proof-Of-Concept Study
Authors: Jefferson Katherine , Semnani-Azad Zhila , Wong Christina , L’Abbé Mary R. , Arcand JoAnne
Published: September 2019

Despite public health efforts to reduce dietary sodium, sodium intakes in most countries remains high. The purpose of this study was to determine if using novel web-based tools that provide tailored feedback, the Sodium Calculator and Sodium Calculator Plus, improves users’ sodium-related knowledge, attitudes, and intended behaviours (KAB). In this single arm pre- and post-test study, 199 healthy adults aged 18–34 years completed a validated questionnaire to assess changes to sodium-related KAB before and after using the calculators. After using the calculators, the proportion of participants who accurately identified the sodium adequate intake and chronic disease risk reduction level increased (19% to 74% and 23% to 74%, respectively, both p = 0.021). The proportion accurately self-assessing their sodium intake as ‘high’ also increased (41% to 66%, p = 0.021). Several intended behavioural changes were reported, i.e., buying foods with sodium-reduced labels, using the Nutrition Facts table, using spices and herbs instead of salt, and limiting eating out. Evidence-based eHealth tools that assess and provide personalized feedback on sodium intake have the potential to aid in facilitating sodium reduction in individuals. This study is an important first step in evaluating and optimizing the implementation of eHealth tools to help reduce Canadians’ sodium intakes.
Asthma and Dietary Intake of Fish, Seaweeds, and Fatty Acids in Korean Adults
Authors: Kim Eun-kyung , Ju Se-Young
Published: September 2019

The dietary intake of fish and fatty acid may influence the risk of asthma, yet epidemiological research remains controversial and inconclusive. We examined the association between asthma and the dietary intake of fish, seaweeds, and fat in a Korean population, aged 19 to 64 years, using the data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2013–2016 (n = 13,038). The prevalence of doctor-diagnosed asthma and medication prescribed asthma were 2.5% and 1.0%, respectively. The subjects with medication prescribed asthma had significantly lower consumption of seaweeds (p = 0.0110) and lower n3/n6 polyunsaturated fatty acid (PUFA) (p = 0.0275) as compared to subjects without medication prescribed asthma. Multiple logistic regression analysis showed that the odds ratio (OR) (95% confidence interval, CI) of doctor-diagnosed asthma in the highest quartile were 0.63 (0.41–0.97) and 0.66 (0.44–1.00) for fish and seaweeds respectively, compared to the lowest quartile after adjusting confounding factors. Furthermore, there were significant inverse associations between medication prescribed asthma and seaweeds [OR (95% CI) = 0.37 (0.19–0.70)], n-3 PUFA [OR (95% CI) = 0.43 (0.21–0.89)] and n3/n6 [OR (95% CI) = 0.47 (0.22–0.99)] intake after adjusting for confounding factors. These results suggest, that the higher consumption of fish and seaweed and the high ratio of n-3 to n-6 PUFA may be associated with a lower prevalence of asthma.
Janthinobacterium lividum as An Emerging Pathogenic Bacterium Affecting Rainbow Trout (Oncorhynchus mykiss) Fisheries in Korea
Authors: Oh Woo Taek , Giri Sib Sankar , Yun Saekil , Kim Hyoun Joong , Kim Sang Guen , Kim Sang Wha , Kang Jeong Woo , Han Se Jin , Kwon Jun , Jun Jin Woo , Park Se Chang
Published: September 2019

Janthinobacterium spp. are normally considered non-pathogenic, and few pathogenesis-related studies have been reported. Here, we report the first isolation of Janthinobacterium lividum in Korea as a pathogenic bacterium infecting rainbow trout. Mass mortality was observed at one rainbow trout hatchery, and dead fish were necropsied. Gram-negative, nonmotile, rod-shaped bacteria that grew on Cytophaga agar were isolated. A specific violet pigmentation was observed after 7 days of cultivation, and the species were characterized on the basis of the analysis of the 16S rRNA gene. Because no research has focused so far on the pathogenicity of these bacteria, our study was directed to their pathogenic role based on infection-induced histopathology. Examination of stained tissue sections revealed severe renal bacteraemia and tubule degeneration. Other tissue sections, including sections from the liver and the spleen, were relatively clear. The measured half-maximal lethal dose (LD50) was approximately 3 × 105 colony-forming units/fish, suggesting that this bacterium may be an opportunistic pathogen in rainbow trout fisheries. Since the bacterium commonly dwells in soil and most water for rainbow trout fisheries in Korea is supplied from ground water, the bacteria may naturally flow into the aquatic environment. Therefore, recognition of any pathogenic role of J. lividum is important for the prevention of disease in aquaculture.
The Impact of Childhood Maltreatment on Intravenous Ketamine Outcomes for Adult Patients with Treatment-Resistant Depression
Authors: O’Brien Brittany , Lijffijt Marijn , Wells Allison , Swann Alan C. , Mathew Sanjay J.
Published: September 2019

Childhood maltreatment is associated with a poor treatment response to conventional antidepressants and increased risk for treatment-resistant depression (TRD). The N-methyl-D-aspartate receptor (NDMAR) antagonist ketamine has been shown to rapidly improve symptoms of depression in patients with TRD. It is unknown if childhood maltreatment could influence ketamine’s treatment response. We examined the relationship between childhood maltreatment using the Childhood Trauma Questionnaire (CTQ) and treatment response using the Quick Inventory of Depressive Symptoms–Self Report (QIDS-SR) in TRD patients receiving intravenous ketamine at a community outpatient clinic. We evaluated treatment response after a single infusion (n = 115) and a course of repeated infusions (n = 63). Repeated measures general linear models and Bayes factor (BF) showed significant decreases in QIDS-SR after the first and second infusions, which plateaued after the third infusion. Clinically significant childhood sexual abuse, physical abuse, and cumulative clinically significant maltreatment on multiple domains (maltreatment load) were associated with better treatment response to a single and repeated infusions. After repeated infusions, higher load was also associated with a higher remission rate. In contrast to conventional antidepressants, ketamine could be more effective in TRD patients with more childhood trauma burden, perhaps due to ketamine’s proposed ability to block trauma-associated behavioral sensitization.
A Valid Bisphosphonate Modified Calcium Phosphate-Based Gene Delivery System: Increased Stability and Enhanced Transfection Efficiency In Vitro and In Vivo
Authors: Zhao Ming , Li Ji , Chen Dawei , Hu Haiyang
Published: September 2019

Calcium phosphate (CaP) nanoparticles, as a promising vehicle for gene delivery, have been widely used owing to their biocompatibility, biodegradability and adsorptive capacity for nucleic acids. Unfortunately, their utility in vivo has been profoundly restricted due to numerous technical barriers such as the lack of tissue specificity and limited transfection efficiency, as well as uncontrollable aggregation over time. To address these issues, an effective conjugate folate-polyethylene glycol-pamidronate (shortened as FA-PEG-Pam) was designed and coated on the surface of CaP/NLS/pDNA (CaP/NDs), forming a versatile gene carrier FA-PEG-Pam/CaP/NDs. Inclusion of FA-PEG-Pam significantly reduced the size of CaP nanoparticles, thus inhibiting the aggregation of CaP nanoparticles. FA-PEG-Pam/CaP/NDs showed better cellular uptake than mPEG-Pam/CaP/NDs, which could be attributed to the high-affinity interactions between FA and highly expressed FR. Meanwhile, FA-PEG-Pam/CaP/NDs had low cytotoxicity and desired effect on inducing apoptosis (71.1%). Furthermore, FA-PEG-Pam/CaP/NDs showed admirable transfection efficiency (63.5%) due to the presence of NLS peptides. What’s more, in vivo studies revealed that the hybrid nanoparticles had supreme antitumor activity (IR% = 58.7%) among the whole preparations. Altogether, FA-PEG-Pam/CaP/NDs was expected to be a hopeful strategy for gene delivery.
Sulfonamide Allergies
Authors: Giles Amber , Foushee Jaime , Lantz Evan , Gumina Giuseppe
Published: September 2019

As one of the earliest developed antimicrobial classes, sulfonamides remain important therapeutic options for the empiric and definitive treatment of various infectious diseases. In the general population, approximately 3–8% of patients are reported to experience a sulfonamide allergy. Sulfonamide allergies can result in various physical manifestations; however, rash is reported as the most frequently observed. In patients with human immunodeficiency virus (HIV), dermatologic reactions to sulfonamide antimicrobial agents occur 10 to 20 times more frequently compared to immunocompetent patients. This article describes the incidence, manifestations, and risk factors associated with sulfonamide allergies. The potential for cross-reactivity of allergies to sulfonamide antimicrobials with nonantimicrobial sulfonamide medications is also reviewed. Data suggest that substitutions at the N1 and N4 positions are the primary determinants of drug allergy instead of the common sulfonamide moiety. For patients with an indication for a sulfonamide antimicrobial with a listed allergy, it is important for healthcare practitioners to adequately assess the allergic reaction to determine appropriate management. Rechallenge and desensitization strategies may be appropriate for patients with delayed maculopapular eruptions, while alternative treatment options may be prudent for more severe reactions. Available data suggests a low risk of cross-allergenicity between sulfonamide antimicrobial and nonantimicrobial agents.
Current Status and Future Prospects in Herbicide Discovery
Authors: Dayan Franck E.
Published: September 2019

Herbicides represent about 60% of the pesticides (by volume) used worldwide. The success of herbicides can be attributed in part to a relatively steady discovery of one unique mechanisms of action (MOA) every two years from the early 1950s to the mid-1980s. While this situation changed dramatically after the introduction of glyphosate-resistant crops, evolution of resistance to glyphosate has renewed the agrichemical industry interest in new chemistry interacting with novel target sites. This review analyses recent characterization of new herbicide target sites, the chemical classes developed to inhibit these target sites, and where appropriate the innovative technologies used in these discovery programs.
Feasibility Study of Applying Modified Nano-SiO2 Hyperbranched Copolymers for Enhanced Oil Recovery in Low-Mid Permeability Reservoirs
Authors: Lai Nanjun , Tang Lei , Jia Na , Qiao Dongyu , Chen Jianlin , Wang Yong , Zhao Xubin
Published: September 2019

To improve oil recovery significantly in low-mid permeability reservoirs, a novel modified nano-SiO2 hyperbranched copolymer (HPBS), consisting of polyacrylamide as hydrophilic branched chains and modified nano-SiO2 as the core, was synthesized via an in situ free radical polymerization reaction. The structure and properties of the hyperbranched copolymer were characterized through a range of experiments, which showed that HBPS copolymers have better stability and enhanced oil recovery (EOR) capacity and also smaller hydrodynamic radius in comparison with hydrolyzed polyacrylamide (HPAM). The flooding experiments indicated that when a 1000 mg/L HPBS solution was injected, the resistance factor (RF) and residual resistance factor (RRF) increased after the injection. Following a 98% water cut after preliminary water flooding, 0.3 pore volume (PV) and 1000 mg/L HPBS solution flooding and extended water flooding (EWF) can further increase the oil recovery by 18.74% in comparison with 8.12% oil recovery when using HPAM. In this study, one can recognize that polymer flooding would be applicable in low-mid permeability reservoirs.
A Review on Synthesis of Mullite Ceramics from Industrial Wastes
Authors: Choo Thye Foo , Mohd Salleh Mohamad Amran , Kok Kuan Ying , Matori Khamirul Amin
Published: September 2019

Some industrial wastes are shown to be useful in the production of mullite ceramics. These industrial wastes are rich in certain metal oxides such as silica (SiO2) and alumina (Al2O3). This gives wastes the potential to be used as a starting material source for mullite ceramics preparation. The purpose of this review paper is to compile and review various mullite ceramics preparation methods that utilized a variety of industrial wastes as starting materials. This review also describes the sintering temperatures and chemical additives used in the preparation and its effects. A comparison of both mechanical strength and thermal expansion of the reported mullite ceramics prepared from various industrial wastes were also addressed in this work.
Classification of Mangrove Species Using Combined WordView-3 and LiDAR Data in Mai Po Nature Reserve, Hong Kong
Authors: Li Qiaosi , Wong Frankie Kwan Kit , Fung Tung
Published: September 2019

Mangroves have significant social, economic, environmental, and ecological values but they are under threat due to human activities. An accurate map of mangrove species distribution is required to effectively conserve mangrove ecosystem. This study evaluates the synergy of WorldView-3 (WV-3) spectral bands and high return density LiDAR-derived elevation metrics for classifying seven species in mangrove habitat in Mai Po Nature Reserve in Hong Kong, China. A recursive feature elimination algorithm was carried out to identify important spectral bands and LiDAR (Airborne Light Detection and Ranging) metrics whilst appropriate spatial resolution for pixel-based classification was investigated for discriminating different mangrove species. Two classifiers, support vector machine (SVM) and random forest (RF) were compared. The results indicated that the combination of 2 m resolution WV-3 and LiDAR data yielded the best overall accuracy of 0.88 by SVM classifier comparing with WV-3 (0.72) and LiDAR (0.79). Important features were identified as green (510–581 nm), red edge (705–745 nm), red (630–690 nm), yellow (585–625 nm), NIR (770–895 nm) bands of WV-3, and LiDAR metrics relevant to canopy height (e.g., canopy height model), canopy shape (e.g., canopy relief ratio), and the variation of height (e.g., variation and standard deviation of height). LiDAR features contributed more information than spectral features. The significance of this study is that a mangrove species distribution map with satisfactory accuracy can be acquired by the proposed classification scheme. Meanwhile, with LiDAR data, vertical stratification of mangrove forests in Mai Po was firstly mapped, which is significant to bio-parameter estimation and ecosystem service evaluation in future studies.
The GFZ GRACE RL06 Monthly Gravity Field Time Series: Processing Details and Quality Assessment
Authors: Dahle Christoph , Murböck Michael , Flechtner Frank , Dobslaw Henryk , Michalak Grzegorz , Neumayer Karl , Abrykosov Oleh , Reinhold Anton , König Rolf , Sulzbach Roman , Förste Christoph
Published: September 2019

Time-variable gravity field models derived from observations of the Gravity Recovery and Climate Experiment (GRACE) mission, whose science operations phase ended in June 2017 after more than 15 years, enabled a multitude of studies of Earth’s surface mass transport processes and climate change. The German Research Centre for Geosciences (GFZ), routinely processing such monthly gravity fields as part of the GRACE Science Data System, has reprocessed the complete GRACE mission and released an improved GFZ GRACE RL06 monthly gravity field time series. This study provides an insight into the processing strategy of GFZ RL06 which has been considerably changed with respect to previous GFZ GRACE releases, and modifications relative to the precursor GFZ RL05a are described. The quality of the RL06 gravity field models is analyzed and discussed both in the spectral and spatial domain in comparison to the RL05a time series. All results indicate significant improvements of about 40% in terms of reduced noise. It is also shown that the GFZ RL06 time series is a step forward in terms of consistency, and that errors of the gravity field coefficients are more realistic. These findings are confirmed as well by independent validation of the monthly GRACE models, as done in this work by means of ocean bottom pressure in situ observations and orbit tests with the GOCE satellite. Thus, the GFZ GRACE RL06 time series allows for a better quantification of mass changes in the Earth system.