bluuebunny/crossref_metadata_2025 huggingface dataset:
EVALUATION OF STROKE REHABILITATION SERVICES IN THE IN-HOSPITAL PHASE: FINDINGS FROM A TERTIARY CARE CENTRE IN INDIA
Authors: Makkar Mridul , Singh Chawla Nistara , Jonas Injety Ranjit , B.C Gandhi Dorcas , D. Pandian Jeyaraj
Published: May 2023

Background- Stroke rehabilitation involves a multidisciplinary team providing comprehensive care to the patient.(1) The functioning of Stroke Units (SU), the highest evidence available for stroke care, is guided by the World Stroke Organisations (WSO) roadmap of core recommendations and key quality indicators.(2) Objectives- To evaluate the quality of stroke rehabilitationin comparison to the WSO core recommendations at a tertiary care centre in India Methodology-A mixed method design with an exploratory research model was used. The study was conducted in 2 phases including retrospective data extraction from medical records and telephonic follow-up on the patients functional status and adherence to physiotherapy post-discharge. 84 patient records (those admitted between Jan â€“June 2021) were screened. Data was extracted from 49 patient files that fulfilled inclusion criteria. 35 patients were excluded due to unavailability of patient files, non-stroke related hospital admissions. In Phase 2, qualitative data was gathered using telephonic interviews, from 7 patients who consented for the same. Results- The mean age of the sample was 56.9 Â±13years with approximately two third being males and a predominance towards ischaemic strokes (62%). Those with severe impairment on Fugl Meyer assessment were 28% of the sample. It was observed that there was inconsistent documentation of various core recommendations provided by WSO (<20%) while 16% of the services provided were not documented at all. Only two of the five key quality indicators of stroke rehab were documented.
SURVEY OF SCID GENE AND IMMUNOLOGICAL STATUS IN ARABIAN MARES AND FOALS
Authors:   Department of Clinical Pathology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh 13736, QG, Egypt., A.E Elsaber , K.M. Fararah ,   Department of Clinical Pathology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh 13736, QG, Egypt., A.F. Samir ,   Department of Clinical Pathology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh 13736, QG, Egypt., Abou ElEla Nahla Hussin ,   Genome Research Unit, Animal Health Research Institute, Agriculture Center (ARC), 12618, Dokki, Giza, Egypt., A.N. Sargious Mary ,   Genome Research Unit, Animal Health Research Institute, Agriculture Center (ARC), 12618, Dokki, Giza, Egypt.
Published: May 2023

Horses have been shown to have the deadly genetic condition calledsevere combined immunodeficiency (SCID). Animals with the condition are unable to produce specific antigens for immunological responses as a result, they become extremely vulnerable to pathogenic pathogens and die before six months.The control and responses to pathogens of neonatal and young foals immune responses differ from those of adults. The purpose of this study to determine carrier of SCID gene in Arabian foals and mares in addition assessing cellular and humoral immunity in Arabian foals and mares. Thirty-eight, Arabian foals and mares were examined.Hair samples were examined for detection of SCID gene by fragment analysis. While blood samples were collected for erythrogram and leukogram. Also, immunoglobulins including Ig E, Ig G, Ig A and Ig M. Also, SAA and fibrinogen were measured in serum and genes expression using Real Time-PCR were performed for IL-10, IL-6, TNFÎ± and TLR 4 mRNA. All samples were homozygous and free from SCID gene. RBCS and monocytes showed significantly high value in foals compared to mares while, there were significant high value in MCV, IgG, IgM, IL-10, IL-6, TNF-Î±, TLR 4 mRNA expression in mares compared to foals. SAA and Fibrinogen showed non-significant difference in mares and foals.SCID diagnostic tests will aid in breeding programme selection to prevent carrier-to-carrier mating. Also assessing immunity in mares and foals is very important tools to determine the optimal immunological pathways and provide fresh preventative measures to ward off contagious diseases.
TO STUDY HEMATOLOGICAL PROFILE IN COVID-19 PATIENTS IN RELATION WITH PROGNOSIS AND OUTCOME:- A CROSS SECTIONAL OBSERVATIONAL STUDY
Authors:   Junior Resident ,MD General Medicine., Kondamangal Seema , Ghodeswar Shekhar ,   Associate Professor, MD General Medicine., K. Saranya ,   Assistant Professor, MD General Medicine.
Published: May 2023

Background: SARS-CoV-2 infection are quite diverse, ranging from asymptomatic disease to pneumonia and potentially fatal consequences. The use of routine blood investigation parameters as a marker of disease severity will results in improved clinical awareness to identify the target patients at higher risk. This study aimed to evaluate haematological profile in COVID-19 patients in relation with outcome test in Covid 19 positive patients. Objective: To study hematological profile in COVID-19 patients in relation with prognosis and outcome. Material & Methods: The present hospital based cross sectional observational study carried among total sample size of 384 patients aged 12 years and above who have SARS-CoV-2 infection confirmed by reverse transcriptaseâ€“polymerase- chain-reaction assay and/or Rapid Antigen test and admitted in medicine ward at tertiary care centre during Jan 2021 to Dec 2022. The study was conducted after obtaining clearance from the Ethical Committee of the institute. Patients with haematological malignancies and hemoglobinopathies like thalassemia and sickle cell disease were excluded. Data of each patient was collected in special proforma which includes clinical manifestations and laboratory values. Results: The mean age of the study population was 42.50 Â±10.94 years with male predominance. (63.28%). Among 384 patients, 102 (26.56%) patients were having anaemia. Low MCV in 48.17%, while N/L ratio was >3.53 in 165 (42.96%) patients. It has been seen that there was statistically significant relation between the mean values of Surviours and non-surviours with respect to RDW, TLC, NLR and Platelets. Conclusion: The present study concludes that laboratory parameters like RDW,MPV, Platelet count, Total leucocyte count ,Neutrophils count ,Lymphocytes count, N/L ratio can be considered as early prognostic markers of COVID 19 disease.
AN EFFECTIVE MACHINE LEARNING APPRAOCH FOR CHRONIC KIDNEY DISEASE DETECTION
Authors:   Department of Electronics & Communication Engineering, N.B.K.R. Institute of Science & Technology, Vidyanagar, Andhra Pradesh, India., Nagarjuna Reddy G. , Dhana Lakshmi B. ,   Department of Electronics & Communication Engineering, N.B.K.R. Institute of Science & Technology, Vidyanagar, Andhra Pradesh, India., Jaya Sree C. ,   Department of Electronics & Communication Engineering, N.B.K.R. Institute of Science & Technology, Vidyanagar, Andhra Pradesh, India., Lokesh A. ,   Department of Electronics & Communication Engineering, N.B.K.R. Institute of Science & Technology, Vidyanagar, Andhra Pradesh, India., Madhuri G. ,   Department of Electronics & Communication Engineering, N.B.K.R. Institute of Science & Technology, Vidyanagar, Andhra Pradesh, India.
Published: May 2023

Chronic kidney disease (CKD) is a global health problem with high mortality and morbidity and mortality. Real-time performance using machine learning. In this study, we introduce machine learning for CKD diagnosis. CKD data is from the University of California, Irvine (UCI) Machine Learning Repository, which contains many missing values. KNN assignment selects multiple completed models with the best values â€‹â€‹to predict missing data for each incomplete model and is used to load missing values.Although patients may ignore certain measures for a variety of reasons, missing data is often found in real clinical settings. After solving the missing data, models are constructed using machine learning algorithms (logistic regression, random forest, support vector machine, k-nearest neighbor, Naive Bayesian classifier, and feedforward neural network). Random forest machine learning models are the most accurate in this task.
A FACE VITIMADA: MORBIDADE ENTRE MULHERES ATENDIDAS EM SERVIÇOS SENTINELAS NO BRASIL
Authors: De Azevedo Machado Flávia Christiane , Serejo da Costa Anna Paula , Fernandes Ferreira Maria Ângela
Published: May 2023

Introdução: Ao longo da história, muitos homens utilizam-se da violência contra suas parceiras como forma de afirmação da sua identidade e domínio viril. Em muitas situações, as agressões são direcionadas à face que justamente representa o centro da atenção do ser humano. Objetivo: O presente artigo tem como objetivo analisar os atendimentos de emergência em mulheres vítimas de violência na região de cabeça e pescoço. Metodologia: Foram analisados dados do inquérito de Vigilância e Acidentes em 25 capitais e no Distrito Federal no ano de 2011. Analisaram-se 351 atendimentos de mulheres adultas entre 15 e 49 anos em relação à ocorrência de violência na região de cabeça e pescoço, o que corresponde a 40,6% das mulheres vítimas de violência. Resultados: A ocorrência da violência foi predominante em mulheres jovens, negras e com pouca escolaridade. As violências foram mais frequentes no domicílio (45,5%) e a referência à intencionalidade do ato de violência pelo agressor predominou entre as vítimas de violência. Em todos os casos, as vítimas de agressão na região de cabeça e pescoço sofreram violência física, sendo o agressor do sexo masculino (77,4%) e identificado como parceiro ou ex-parceiro íntimo em 44,5%. Conclusões: É cada vez mais importante que o serviço esteja preparado para receber essas mulheres vítimas de violência, mediante conformação de Redes de Atenção e efetivação da instersetorialidade. Isto pressupõe, inclusive, a maior inserção do cirurgião-dentista na identificação e acolhimento dessas vítimas para posteriores encaminhamentos.

Palavras-Chave: Violência doméstica, face, morbidade, feminino.
Phytochemicals as Substances that Affect Astrogliosis and their Implications for the Management of Neurodegenerative Diseases
Authors: Forouzanfar Fatemeh , Pourbagher-Shahri Ali Mohammad , Vafaee Farzaneh , Sathyapalan Thozhukat , Sahebkar Amirhossein
Published: May 2023

:

Astrocytes are a multifunctional subset of glial cells that are important in maintaining
the health and function of the central nervous system (CNS). Reactive astrocytes
may release inflammatory mediators, chemokines, and cytokines, as well as neurotrophic
factors. There may be neuroprotective (e.g., cytokines, like IL-6 and TGF-b) and neurotoxic
effects (e.g., IL-1β and TNF-a) associated with these molecules. In response to
CNS pathologies, astrocytes go to a state called astrogliosis which produces diverse and
heterogenic functions specific to the pathology. Astrogliosis has been linked to the progression
of many neurodegenerative disorders. Phytochemicals are a large group of compounds
derived from natural herbs with health benefits. This review will summarize how
several phytochemicals affect neurodegenerative diseases (e.g., Alzheimer’s disease,
Huntington’s disease, amyotrophic lateral sclerosis, and Parkinson’s disease) in basic
medical and clinical studies and how they might affect astrogliosis in the process.
Integrated Network Pharmacology and Metabolomics to Dissect the
Mechanisms of Naringin for Treating Cervical Cancer
Authors: Yin Ziwei , Hua Xuefeng , Lu Minqiang
Published: May 2023

Introduction:

Cervical cancer is one of the malignant cancers with high mortality
among women worldwide. Although vaccines and early detection have reduced cervical cancer
mortality, it remains a malignancy with a high mortality rate in women.

Objective:

We aimed to develop a novel integrated strategy that combines metabolomics with
network pharmacology to explore the therapeutic mechanisms of naringin in cervical cancer. The
mechanism of naringin intervention in cervical cancer was initially clarified by metabolomics and
network pharmacology.

Methods:

The method of LC-MS and network pharmacology for the detection and identification of
potential biomarkers and the mechanisms of action of naringin was used. The metabolites were detected
and identified based on ultra-high-performance liquid chromatography coupled with Quadrupole-
Exactive Orbitrap MS (UHPLC-Q-Exactive Orbitrap MS) and followed by the network
pharmacology analysis.

Results:

In network pharmacology, naringin played a synergetic role through regulatory shared
pathways, such as steroid hormone biosynthesis, sphingolipid signaling pathway and arachidonic
acid metabolism, etc. Besides, the metabolomics analysis showed that 20 differential metabolites
and 10 metabolic pathways were mainly involved in the therapeutic effect of naringin on cervical
cancer. The result showed that naringin treatment for cervical cancer mainly occurs through the
following metabolic pathways: amino acid metabolism and arachidonic acid metabolism.

Conclusion:

This work provided valuable information and a scientific basis for further studies of
naringin in the treatment of cervical cancer.
Design, Synthesis and Molecular Docking Studies of Pyrazoline Derivatives
as PI3K Inhibitors
Authors: Kumar Rohit , Kumar Arvind , Kumar Adarsh , Singh Ankit Kumar , Kumar Pradeep
Published: May 2023

Aim:

Design, synthesis and molecular docking studies of quinoline/naphthalene containing
pyrazoline derivatives as PI3K inhibitors.

Background:

Phosphatidylinositol 3-kinases (PI3Ks) belong to the family of enzymes, which are
associated with various cellular functions such as cell growth, proliferation, differentiation etc.
Overexpression or any changes in these functions may result in various abnormalities, which in
turn cause cancer.

Objectives:

To perform synthesis and molecular docking studies of quinoline/naphthalene containing
pyrazoline derivatives as PI3K inhibitors.

Methods:

2-Chloroquinoline-3-carbaldehyde was synthesized by a reaction of acetanilide and
POCl3. The latter was reacted with substituted acetophenones to synthesize chalcones, which were
reacted with substituted phenyl hydrazines to yield pyrazoline derivatives (Series I). Similarly, pchloro
benzaldehyde was reacted with 2-acetonapthone to yield chalcone with substituted phenyl
hydrazines to yield pyrazoline derivatives (Series II).

Results:

The synthetic compounds were subjected to molecular modelling experiments using Schrodinger
2016 software and evaluated in silico for their PI3K binding affinities. All the compounds had better docking
scores than AMG-319 (-4.36 Kcal/mol) and comparable docking scores with PI-103 (-6.83 Kcal/mol).

Conclusion:

Compounds 5 and 3 had the best docking scores (-7.85 and -7.17 Kcal/mol, respectively). The
synthesized compounds have better docking scores than the reference drug AMG-319. As a result, they
might be used as lead molecules in investigating PI3K inhibitors.
A Mini-Review on Elisa-Based Diagnosis of Schistosomiasis
Authors: dos Santos Michelli , de Faria Mariana Teixeira , da Silva Jonatas Oliveira , Gandra Isadora Braga , Ribeiro Anna Julia , Silva Kamila Alves , Nogueira Lais Moreira , Machado Juliana Martins , da Silveira Mariano Reysla Maria , Gonçalves Ana Alice Maia , Ludolf Fernanda , Candia-Puma Mayron Antonio , Chávez-Fumagalli Miguel Angel , Campos-da-Paz Mariana , Giunchetti Rodolfo Cordeiro , Galdino Alexsandro Sobreira
Published: May 2023

Background:

schistosomiasis is a neglected tropical parasitic disease caused by trematode worms of the genus schistosoma, which affects approximately 240 million people worldwide. the diagnosis of the disease can be performed by parasitological, molecular, and/or immunological methods, however, the development of new diagnostic methods still essential to guide policy decisions, monitor disease trends and assess the effectiveness of interventions.

Objective:

in this sense, the current work summarizes the findings of a systematic review regarding antigens applied in the enzyme-linked immunosorbent assay test, which were patented and published over the last ten years.

Methods:

the literature search strategy used medical subject heading (mesh) terms to define as descriptors. “schistosoma mansoni” was used in arrangement with the descriptors “immunoassay”, “enzyme-linked immunosorbent assay”, “elisa”, and “antigens”, using the “and” connector. the patent search was done using keywords, including diagnosis and schistosoma or schistosomiasis or schistosome. several databases were employed for the patent search, such as intellectual property national institute; european patent office; the united states patent and trademark office; patent scope, and google patents.

Results:

forty-one articles were retrieved, of which only five met the eligibility criteria. seventeen patents were taken from the databases, and a brief description of the most relevant inventions is given here.

Conclusion:

schistosomiasis is considered the most important helminthic disease in worldwide. therefore, it is important to of searching for and develops diagnostic methods based on serology to reduce morbidity and mortality caused by the disease.
Recent Advances in the Development of Membrane-derived Vesicles for
Cancer Immunotherapy
Authors: Xiao Yuai , Wu Minliang , Xue Chunyu , Wang Yuchong
Published: May 2023

The surface proteins on cell membranes enable the cells to have different properties, such as
high biocompatibility, surface modifiability, and homologous targeting ability. Cell-membrane-derived
vesicles have features identical to those of their parental cells, which makes them one of the most promising
materials for drug delivery. Recently, as a result of the impressive effects of immunotherapy in
cancer treatment, an increasing number of researchers have used cell-membrane-derived vesicles to
enhance immune responses. To be more specific, the membrane vesicles derived from immune cells,
tumor cells, bacteria, or engineered cells have the antigen presentation capacity and can trigger strong
anti-tumor effects of the immune system. In this review, we first indicated a brief description of the
vesicles and then introduced the detection technology and drug-loading methods for them. Secondly, we
concluded the characteristics and applications of vesicles derived from different sources in cancer immunotherapy.
Traditional and Innovative Anti-seizure Medications Targeting Key Physiopathological
Mechanisms: Focus on Neurodevelopment and Neurodegeneration
Authors: Sciaccaluga Miriam , Ruffolo Gabriele , Palma Eleonora , Costa Cinzia
Published: May 2023

Despite the wide range of compounds currently available to treat epilepsy, there is still no
drug that directly tackles the physiopathological mechanisms underlying its development. Indeed, antiseizure
medications attempt to prevent seizures but are inefficacious in counteracting or rescuing the
physiopathological phenomena that underlie their onset and recurrence, and hence do not cure epilepsy.
Classically, the altered excitation/inhibition balance is postulated as the mechanism underlying epileptogenesis
and seizure generation. This oversimplification, however, does not account for deficits in
homeostatic plasticity resulting from either insufficient or excessive compensatory mechanisms in response
to a change in network activity. In this respect, both neurodevelopmental epilepsies and those
associated with neurodegeneration may share common underlying mechanisms that still need to be fully
elucidated. The understanding of these molecular mechanisms shed light on the identification of new
classes of drugs able not only to suppress seizures, but also to present potential antiepileptogenic effects
or “disease-modifying” properties.
Prakiraan Kebutuhan Energi Listrik Dengan Jaringan Saraf Tiruan (Artificial Neural Network) Metode Backpropagation Tahun 2020-2025
Authors: Setyowati Diah , Sunardiyo Said
Published: May 2023

Kebutuhan energi listrik merupakan salah satu hal utama yang diprioritaskan oleh penyedia listrik. Perlunya dilalukan perencanaan terhadap pemenuhan kebutuhan energi listrik oleh penyedia listrik setiap tahunnya. Penelitian dilakukan untuk memprediksi kebutuhan energi listrik PT PLN (Persero) UP3 Semarang tahun 2020-2025 dengan mengembangkan suatu model Jaringan Saraf Tiruan metode Backpropagation menggunakan software Matlab. Beberapa variabel yang digunakan yaitu jumlah penduduk, jumlah pelanggan, PDRB, daya tersambung, beban puncak dan total produksi energi listrik. Variabel tersebut merupakan beberapa faktor yang mempengaruhi peningkatanÂ  kebutuhan energi listrik. Hasil penelitian menghasilkan Mean Absolute Percentage Error (MAPE) sebesar 0,4% dan Growth of Total % (GOT %) sebesar 2,7% setiap tahunnya.
PERLINDUNGAN HUKUM TERHADAP PEMBELA HAK ASASI MANUSIA PERSPEKTIF TEORI ALASAN PENGHAPUS PIDANA
Authors: Rizal Moch. Choirul
Published: May 2023

Legal protection of human rights defenders in Indonesia is at an alarming point. This sociolegal study focused on the objective conditions of legal protection for human rights defenders and the legal protection for human rights defenders from a theoretical perspective on the reasons for erasers punishment. The results are human rights defenders still experience arrests, shootings, clashes and torture. There are also several criminal law policies that have the potential to violate the rights and guarantees of legal protection for human rights defenders. Second, "the theory of lesser evils" can be used as a basis for providing legal protection to human rights defenders. As long as the actions of human rights defenders are to implement Article 67 of Law No. 32 of 2009, for example, human rights defenders can be seen as "implementing the laws and regulations" and protected by Article 66 of Law No. 32 of 2009, so that Article 50 of the Criminal Code can be applied as an excuse to eradicate crimes. In the future, guidelines for the criminalization of human rights defenders when dealing with criminal case settlement processes are also needed.
Genomic Insights Into the Evolution and Demographic History of the SARS-CoV-2 Omicron Variant: Population Genomics Approach
Authors: Garg Kritika M , Lamba Vinita , Chattopadhyay Balaji
Published: May 2023

Background

A thorough understanding of the patterns of genetic subdivision in a pathogen can provide crucial information that is necessary to prevent disease spread. For SARS-CoV-2, the availability of millions of genomes makes this task analytically challenging, and traditional methods for understanding genetic subdivision often fail.

Objective

The aim of our study was to use population genomics methods to identify the subtle subdivisions and demographic history of the Omicron variant, in addition to those captured by the Pango lineage.

Methods

We used a combination of an evolutionary network approach and multivariate statistical protocols to understand the subdivision and spread of the Omicron variant. We identified subdivisions within the BA.1 and BA.2 lineages and further identified the mutations associated with each cluster. We further characterized the overall genomic diversity of the Omicron variant and assessed the selection pressure for each of the genetic clusters identified.

Results

We observed concordant results, using two different methods to understand genetic subdivision. The overall pattern of subdivision in the Omicron variant was in broad agreement with the Pango lineage definition. Further, 1 cluster of the BA.1 lineage and 3 clusters of the BA.2 lineage revealed statistically significant signatures of selection or demographic expansion (Tajima’s D<−2), suggesting the role of microevolutionary processes in the spread of the virus.

Conclusions

We provide an easy framework for assessing the genetic structure and demographic history of SARS-CoV-2, which can be particularly useful for understanding the local history of the virus. We identified important mutations that are advantageous to some lineages of Omicron and aid in the transmission of the virus. This is crucial information for policy makers, as preventive measures can be designed to mitigate further spread based on a holistic understanding of the variability of the virus and the evolutionary processes aiding its spread.
Comparison of Reporting and Transparency in Published Protocols and Publications in Umbrella Reviews: Scoping Review
Authors: Zhao Liang , Shen Caiyi , Liu Ming , Zhang Jiaoyan , Cheng Luying , Li Yuanyuan , Yuan Lanbin , Zhang Junhua , Tian Jinhui
Published: May 2023

Background

Inconsistencies between a protocol and its umbrella review (UR) may mislead readers about the importance of findings or lead to false-positive results. Furthermore, not documenting and explaining inconsistencies in the UR could reduce its transparency. To our knowledge, no study has examined the methodological consistency of the protocols with their URs and assessed the transparency of the URs when generating evidence.

Objective

This study aimed to investigate the inconsistency of protocols with their URs in the methodology and assess the transparency of the URs.

Methods

We searched medical-related electronic databases from their inception to January 1, 2022. We investigated inconsistencies between protocols and their publications and transparencies in the search strategy, inclusion criteria, methods of screening and data extraction, quality assessment, and statistical analysis.

Results

We included 31 protocols and 35 publications. For the search strategy, 39 inconsistencies between the protocols and their publications were found in 26 of the 35 (74%) URs, and 16 of these inconsistencies were indicated and explained. There were 84 inconsistencies between the protocols and their URs regarding the inclusion criteria in 31 of the 35 (89%) URs, and 29 of the inconsistencies were indicated and explained. Deviations from their protocols were found in 12 of the 32 (38%) URs reporting the methods of screening, 14 of the 30 (47%) URs reporting the methods of data extraction, and 11 of the 32 (34%) URs reporting the methods for quality assessment. Of the 35 URs, 6 (17%) were inconsistent with their protocols in terms of the tools for quality assessment; one-half (3/6, 50%) of them indicated and explained the deviations. As for the statistical analysis, 31 of the 35 (89%) URs generated 61 inconsistencies between the publications and their protocols, and 16 inconsistencies were indicated and explained.

Conclusions

There was a high prevalence of inconsistencies between protocols and publications of URs, and more than one-half of the inconsistencies were not indicated and explained in the publications. Therefore, how to promote the transparency of URs will be a major part of future work.
Referring Adolescent Primary Care Patients to Single-Session Interventions for Anxiety and Depression: Protocol for a Feasibility Study
Authors: Eyllon Mara , Dalal Michelle , Jans Laura , Sotomayor Ian , Peloquin Gabrielle , Yon James , Fritz Rochelle , Schleider Jessica
Published: May 2023

Background

Despite the growing prevalence of depression and anxiety among adolescents, fewer than half access appropriate mental health care. Single-session interventions (SSIs) for depression and anxiety offered in primary care are a promising approach to bridging the treatment gap.

Objective

We aimed to implement a clinical workflow for primary care and behavioral health providers to refer patients aged 13 to 17 years with mild to moderate depression and anxiety symptoms to Project YES (Youth Empowerment and Support), an open-access SSI platform, in a large group medical practice with an integrated behavioral health department.

Methods

Pediatric primary care and integrated behavioral health providers will be educated on the benefits of Project YES for adolescent anxiety and depression and trained in a workflow integrated within the electronic health record system, Epic, to refer patients during well-child visits and pediatric behavioral health visits. Patients with mild to moderate internalizing symptoms based on the 17-item Pediatric Symptom Checklist or youth Pediatric Symptom Checklist will be invited to try an SSI through Project YES. We will examine provider uptake and perceptions of acceptability, feasibility, and appropriateness over time.

Results

The rollout will take place between November 2022 and May 2023, when outcomes will be evaluated. Data analysis and manuscript writing are anticipated to be completed during the summer of 2023.

Conclusions

SSIs such as those available through Project YES have the potential to provide low-cost, evidence-based mental health treatment to adolescents with mild to moderate depression and anxiety. If deemed feasible and acceptable, providing SSIs in primary care settings could significantly improve access to mental health care without taxing pediatric primary care and behavioral health providers.

International Registered Report Identifier (IRRID)

DERR1-10.2196/45666
Characterizing the Discourse of Popular Diets to Describe Information Dispersal and Identify Leading Voices, Interaction, and Themes of Mental Health: Social Network Analysis (Preprint)
Authors: Eaton Melissa C , Probst Yasmine C , Smith Marc A
Published: May 2023

BACKGROUND

Social media has transformed the way health messages are communicated. This has created new challenges and ethical considerations while providing a platform to share nutrition information for communities to connect and for information to spread. However, research exploring the web-based diet communities of popular diets is limited.

OBJECTIVE

This study aims to characterize the web-based discourse of popular diets, describe information dissemination, identify influential voices, and explore interactions between community networks and themes of mental health.

METHODS

This exploratory study used Twitter social media posts for an online social network analysis. Popular diet keywords were systematically developed, and data were collected and analyzed using the NodeXL metrics tool (Social Media Research Foundation) to determine the key network metrics (vertices, edges, cluster algorithms, graph visualization, centrality measures, text analysis, and time-series analytics).

RESULTS

The vegan and ketogenic diets had the largest networks, whereas the zone diet had the smallest network. In total, 31.2% (54/173) of the top users endorsed the corresponding diet, and 11% (19/173) claimed a health or science education, which included 1.2% (2/173) of dietitians. Complete fragmentation and hub and spoke messaging were the dominant network structures. In total, 69% (11/16) of the networks interacted, where the ketogenic diet was mentioned most, with depression and anxiety and eating disorder words most prominent in the “zone diet” network and the least prominent in the “soy-free,” “vegan,” “dairy-free,” and “gluten-free” diet networks.

CONCLUSIONS

Social media activity reflects diet trends and provides a platform for nutrition information to spread through resharing. A longitudinal exploration of popular diet networks is needed to further understand the impact social media can have on dietary choices. Social media training is vital, and nutrition professionals must work together as a community to actively reshare evidence-based posts on the web.
User Compliance With the Health Emergency and Disaster Management System: Systematic Literature Review (Preprint)
Authors: Fitriani Widia Resti , Sutanto Juliana , Handayani Putu Wuri , Hidayanto Achmad Nizar
Published: May 2023

BACKGROUND

Health-related hazards have a detrimental impact on society. The health emergency and disaster management system (Health EDMS), such as a contact-tracing application, is used to respond to and cope with health-related hazards. User compliance with Health EDMS warnings is key to its success. However, it was reported that user compliance with such a system remains low.

OBJECTIVE

Through a systematic literature review, this study aims to identify the theories and corresponding factors that explain user compliance with the warning message provided by Health EDMS.

METHODS

The systematic literature review was conducted using Preferred Reporting Items for Systematic reviews and Meta-Analyses 2020 guidelines. The search was performed using the online databases Scopus, ScienceDirect, ProQuest, IEEE, and PubMed, for English journal papers published between January 2000 and February 2022.

RESULTS

A total of 14 papers were selected for the review based on our inclusion and exclusion criteria. Previous research adopted 6 theories when examining user compliance, and central to the research was Health EDMS. To better understand Health EDMS, based on the literature reviewed, we mapped the activities and features of Health EDMS with the key stakeholders involved. We identified features that require involvement from individual users, which are surveillance and monitoring features and medical care and logistic assistance features. We then proposed a framework showing the individual, technological, and social influencing factors of the use of these features, which in turn affects compliance with the warning message from Health EDMS.

CONCLUSIONS

Research on the Health EDMS topic increased rapidly in 2021 due to the COVID-19 pandemic. An in-depth understanding of Health EDMS and user compliance before designing the system is essential for governments and developers to increase the effectiveness of Health EDMS. Through a systematic literature review, this study proposed a research framework and identified research gaps for future research on this topic.
Predicting Internet Use and Digital Competence Among Older Adults Using Performance Tests of Visual, Physical, and Cognitive Functioning: Longitudinal Population-Based Study (Preprint)
Authors: Heponiemi Tarja , Kainiemi Emma , Virtanen Lotta , Saukkonen Petra , Sainio Päivi , Koponen Päivikki , Koskinen Seppo
Published: May 2023

BACKGROUND

The rapidly increasing role of the internet in obtaining basic services poses challenges, especially for older adults’ capabilities of getting the services they need. Research on the predictors of older adults’ internet use and digital competence is especially relevant given that people are living longer than before, and the age profile of many societies is changing rapidly.

OBJECTIVE

We aimed to examine the associations of objective measures of physical and cognitive impairment with the nonuse of the internet for services and low digital competence among older adults.

METHODS

A longitudinal population-based design was used that combined data from performance tests and self-rated questionnaires. Data were gathered in 2017 and 2020 among 1426 older adults aged between 70 and 100 years in Finland. Logistic regression analyses were used to examine the associations.

RESULTS

Those who had poor near (odds ratio [OR] 1.90, 95% CI 1.36-2.66) or distant vision (OR 1.81, 95% CI 1.21-2.71), restricted or failed abduction of upper arms (OR 1.81, 95% CI 1.28-2.85), and poor results from the word list memory (OR 3.77, 95% CI 2.65-5.36) or word list delayed recall (OR 2.12, 95% CI 1.48-3.02) tests had greater odds for nonuse of the internet for services than their counterparts. Moreover, those who had poor near (OR 2.18, 95% CI 1.57-3.02) or distant vision (OR 2.14, 95% CI 1.43-3.19), poor results from the chair stand test (OR 1.57, 95% CI 1.06-2.31), restricted or failed abduction of upper arms (OR 1.74, 95% CI 1.10-2.76), and poor results from the word list memory (OR 3.41, 95% CI 2.32-5.03) or word list delayed recall (OR 2.05, 95% CI 1.39-3.04) tests had greater odds of low digital competence than their counterparts.

CONCLUSIONS

According to our results, older adults’ impaired physical and cognitive functioning may hamper their possibilities of accessing internet services such as digital health care services. Our results should be considered when planning digital health care services intended to be used by older adults; that is, digital solutions should also be suitable for older adults with impairments. Furthermore, face-to-face services should be provided for those who cannot use digital services, even if they are assisted properly.
Adverse Effects of Virtual and Augmented Reality Interventions in Psychiatry: Systematic Review (Preprint)
Authors: Lundin Robert M , Yeap Yuhern , Menkes David B
Published: May 2023

BACKGROUND

Virtual reality (VR) and augmented reality (AR) are emerging treatment modalities in psychiatry, which are capable of producing clinical outcomes broadly comparable to those achieved with standard psychotherapies.

OBJECTIVE

Because the side effect profile associated with the clinical use of VR and AR remains largely unknown, we systematically reviewed available evidence of their adverse effects.

METHODS

A systematic review was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) framework across 3 mental health databases (PubMed, PsycINFO, and Embase) to identify VR and AR interventions targeting mental health diagnoses.

RESULTS

Of 73 studies meeting the inclusion criteria, 7 reported worsening clinical symptoms or an increased fall risk. Another 21 studies reported “no adverse effects” but failed to identify obvious adverse effects, mainly cybersickness, documented in their results. More concerningly, 45 of the 73 studies made no mention of adverse effects whatsoever.

CONCLUSIONS

An appropriate screening tool would help ensure that VR adverse effects are correctly identified and reported.
Merits and Pitfalls of Social Media as a Platform for Recruitment of Study Participants (Preprint)
Authors: Oudat Qutaibah , Bakas Tamilyn
Published: May 2023

UNSTRUCTURED

Efficient and effective methods of recruiting participants for studies have characteristically come with many challenges. The unprecedented rise of social media platforms such as Facebook and Instagram has revolutionized the ease of recruiting participants as compared to more traditional methods such as newspaper or radio advertisements. While these new advancements may seem to increase the success of recruitment, they are not without their own faults and limitations. In this paper, we intend to dissect the advantages and disadvantages of social media platforms in recruiting participants. Specifically, we will discuss the advantages of targeted and rapid recruitment, engagement, and cost reduction as well as the disadvantages of representativeness, privacy concerns, limited control, and limited access.
Research Status and New Trends of Hepatocellular Carcinoma with
Pulmonary Metastasis (Preprint)
Authors: Zhang Jiachen , Dang Shuangsuo , Yang Yi , Qiao Zhe , Wang Peng , Feng Gaifeng , Feng Gaifeng , Feng Gaifeng
Published: May 2023

BACKGROUND

Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. HCC recurrence and metastasis (most of which are pulmonary metastases ) are the main causes of death in patients. This study aimed to construct a model to analyze and evaluate the relationship between HHC and scientific publications in lung metastatic tumors.

OBJECTIVE

Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. HCC recurrence and metastasis (most of which are pulmonary metastases ) are the main causes of death in patients. This study aimed to construct a model to analyze and evaluate the relationship between HHC and scientific publications in lung metastatic tumors.

METHODS

Collect original research articles related to hepatocellular carcinoma and pulmonary metastases published in the Web of Science Core Collection database before January 5, 2023. Understand the development status of the field of hepatocellular carcinoma and pulmonary metastases through co-authored scientific knowledge maps of countries/regions, institutions and authors, and analyze the subject through co-occurrence keyword maps, co-cited author maps, and distribution of highly cited papers Research hotspots in the field, analyze the research frontiers of the subject field through the co-occurrence keyword frequency and emergence analysis map, and explore the global development trend of the subject field through the co-cited reference map.

RESULTS

A total of 971 articles related to HCC and lung metastasis were included. Both the number of articles published and the frequency of citations have increased significantly over the past five years. The countries/regions, institutions, scholars and journals with the largest number of published articles are China, Fudan Univ, Tang ZY (Zhongshan Hosp, Key Lab Carcinogenesis & Canc Invas, Liver Canc Inst, Fudan Univ) and Hepatology. The countries/regions, institutions, scholars and journals with the most influential published articles are USA, Fudan Univ, Fan J (Zhongshan Hosp, Key Lab Carcinogenesis & Canc Invas, Liver Canc Inst, Fudan Univ) and Am J Clin Pathol. Mol Cancer is the most Effective Journal. The top five co-occurrence keywords are hepatocellular carcinoma, expression, cancer, cell and invasion. The current research frontiers are promote，hepatocellular carcinoma (HCC) and suppresse.

CONCLUSIONS

Chinese scholars and research institutions have absolute academic leadership in the field of HCC and lung metastatic tumor research. The results of this quantitative study can provide a reference for government departments to formulate/modify health policies or measures. At the same time, this research can also help relevant scholars accurately identify research hotspots and frontiers in the research of HCC and lung metastatic tumors, and play an important guiding role in subsequent research.
Internet Use Type, Frequency and Cognitive Function: Evidence From a Representative Sample of Elderly Internet Users in China (Preprint)
Authors: Ma Tianjiao , Liu Mingzheng , Zhang Ruijie , Zhang Siyu , Xun Xiaomeng , Mei Kai
Published: May 2023

BACKGROUND

It is a strong correlation between Internet use and better cognitive function., and it is necessary to further explore among the elderly Internet users.

OBJECTIVE

This study provides evidence support for the use of the Internet for non-drug cognitive function prevention and intervention measures, and establishes policy awareness of active aging.

METHODS

The data is from the China Health and Retirement Longitudinal Research Study for people aged 60 and over in 2018. A total of 671 respondents were included in the analysis. Binary logistic regression analysis was used to evaluate the relationship between Internet use types (chat, watch news, watch video, play games), Internet use frequency and cognitive function.

RESULTS

Among the investigated elderly Internet users, the incidence of Cognitive impairment was 21.91% (147 / 671). There were significant differences in age, gender, depression symptom, and Internet use frequency between the healthy group and cognitive impairment group (p<0.05). After controlling for confounding factors. The Internet use frequency almost every week was 0.404 times that of almost daily (95% confidence interval: 0.206-0.791), and 0.388 times that of not regularly (95% confidence interval: 0.152-0.993).

CONCLUSIONS

For older adults Internet users, the incidence of cognitive impairment is still high, which suggests that there is a relationship between the Internet use frequency and cognitive impairment. Mobile telemedicine for cognitive impairment diseases should consider the utility of Internet use of the elderly, so as to formulate prevention and intervention strategies.
Validation of a Brief Internet-Based Self-Report Measure of Maladaptive Personality and Interpersonal Schema: Confirmatory Factor Analysis (Preprint)
Authors: Kim Hyeonseong , Jeong Seohyun , Hwang Inae , Sung Kiyoung , Moon Woori , Shin Min-Sup
Published: May 2023

BACKGROUND

Existing digital mental health interventions mainly focus on the symptoms of specific mental disorders, but do not focus on Maladaptive Personalities and Interpersonal Schemas (MPISs). As an initial step toward considering personalities and schemas in intervention programs, there is a need for the development of tools for measuring core personality traits and interpersonal schemas known to cause psychological discomfort among potential users of digital mental health interventions. Thus, the MPIS was developed.

OBJECTIVE

The objectives of this study are to validate the MPIS by comparing 2 models of the MPIS factor structure and to understand the characteristics of the MPIS by assessing its correlations with other measures.

METHODS

Data were collected from 234 participants who were using web-based community sites in South Korea, including university students, graduate students, working professionals, and homemakers. All the data were gathered through web-based surveys. Confirmatory factor analysis was used to compare a single-factor model with a 5-factor model. Reliability and correlation analyses with other scales were performed.

RESULTS

The results of confirmatory factor analysis indicated that the 5-factor model (χ2550=1278.1; Tucker-Lewis index=0.80; comparative fit index=0.81; and Root Mean Square Error of Approximation=0.07) was more suitable than the single-factor model (χ2560=2341.5; Tucker-Lewis index=0.52; comparative fit index=0.54; and Root Mean Square Error of Approximation=0.11) for measuring maladaptive personality traits and interpersonal relationship patterns. The internal consistency of each factor of the MPIS was good (Cronbach α=.71-.88), and the correlations with existing measures were statistically significant. The MPIS is a validated 35-item tool for measuring 5 essential personality traits and interpersonal schemas in adults aged 18-39 years.

CONCLUSIONS

This study introduced the MPIS, a concise and effective questionnaire capable of measuring maladaptive personality traits and interpersonal relationship schemas. Through analysis, the MPIS was shown to reliably assess these psychological constructs and validate them. Its web-based accessibility and reduced item count make it a valuable tool for mental health assessment. Future applications include its integration into digital mental health care services, allowing easy web-based administration and aiding in the classification of psychological therapy programs based on the obtained results.

CLINICALTRIAL

ClinicalTrials.gov NCT05952063; https://www.clinicaltrials.gov/study/NCT05952063