bluuebunny/crossref_metadata_2025 huggingface dataset:
Untangling the Context-Specificity of Essential Genes by Means of Machine Learning: A Constructive Experience
Authors: Giordano Maurizio , Falbo Emanuele , Maddalena Lucia , Piccirillo Marina , Granata Ilaria
Published: December 2023

Gene essentiality is a genetic concept crucial for a comprehensive understanding of life and evolution. In the last decade, many essential genes (EGs) have been determined using different experimental and computational approaches, and this information has been used to reduce the genomes of model organisms. A growing amount of evidence highlights that essentiality is a property that depends on the context. Because of their importance in vital biological processes, recognising context-specific EGs (csEGs) could help for identifying new potential pharmacological targets and to improve precision therapeutics. Since most of the computational procedures proposed to identify and predict EGs neglect their context-specificity, we focused on this aspect, providing a theoretical and experimental overview of the literature, data and computational methods dedicated to recognising csEGs. To this end, we adapted existing computational methods to exploit a specific context (the kidney tissue) and experimented with four different prediction methods using the labels provided by four different identification approaches. The considerations derived from the analysis of the obtained results, confirmed and validated also by further experiments for a different tissue context, provide the reader with guidance on exploiting existing tools for achieving csEGs identification and prediction.
Impact of Long-Term Swimming Exercise on Rat Femur Bone Quality
Authors: Freitas Laura , Bezerra Andrea , Resende-Coelho Ana , Gomez-Lazaro Maria , Maciel Leonardo , Amorim Tânia , Fernandes Ricardo J. , Fonseca Hélder
Published: December 2023

Considering the conflicting evidence regarding the potential long-term detrimental effect of swimming during growth on femur quality and fracture risk, our aim was to investigate the effect of eight months of swimming on femur quality. Twenty male eight-week-old Wistar rats were assigned into a swimming (SW; n = 10; 2 h/day, 5 days/week) or active control group (CG; n = 10, housed with running wheel) for eight months. Plasma osteocalcin and C-terminal telopeptide of type I collagen concentrations (ELISA) were assessed at baseline, four, and eight months of protocol. Femur structure (micro-computed tomography), biomechanical properties (three-point bending), and cellular density (histology) were determined after the protocol. SW displayed a lower uncoupling index, suggesting higher bone resorption, lower empty lacunae density, cortical and trabecular femur mass, femur length and cortical thickness, and higher cortical porosity than CG (p < 0.05). Although both biomarkers’ concentrations decreased in both groups throughout the experiment (p < 0.001), there were no significant differences between groups (p > 0.05). No differences were also found regarding biomechanical properties, bone marrow adiposity, and osteocyte and osteoclast densities (p > 0.05). Long-term swimming was associated with unbalanced bone turnover and compromised femur growth, lower femur mass, and deteriorated cortical bone microarchitecture. However, femur trabecular microarchitecture and biomechanical properties were not affected by swimming.
Long-Term Outcome of Lower Extremity Bypass Surgery in Diabetic and Non-Diabetic Patients with Critical Limb-Threatening Ischaemia in Germany
Authors: Surmann Johanna , Meyer Philipp , Epple Jasmin , Schmitz-Rixen Thomas , Böckler Dittmar , Grundmann Reinhart T.
Published: December 2023

Aim: To present the short- and long-term outcomes of lower extremity bypass (LEB) surgery in patients with critical limb-threatening ischaemia (CLTI), comparing diabetic (DM) and non-diabetic (non-DM) patients. Methods: Retrospective analysis of anonymised data from a nationwide health insurance company (AOK). Data from 22,633 patients (DM: n = 7266; non-DM: n = 15,367; men: n = 14,523; women: n = 8110; mean patient age: 72.5 years), who underwent LEB from 2010 to 2015, were analysed. The cut-off date for follow-up was December 31, 2018 (mean follow-up period: 55 months). Results: Perioperative mortality was 10.0% for DM and 8.2% for non-DM (p < 0.001). Patients with crural/pedal bypasses (n = 8558) had a significantly higher perioperative mortality (10.3%) than those with above-the-knee (n = 7246; 5.8%; p < 0.001) and below-the-knee bypasses (n = 6829; 8.9%; p = 0.003). The 9-year survival rates in DM patients were significantly worse, at 21.5%, compared to non-DM, at 31.1% (p < 0.001). This applied to both PAD stage III (DM: 34.4%; non-DM: 45.7%; p < 0.001) and PAD stage IV (DM: 18.5%; non-DM: 25.0%; p < 0.001). Patients with crural/pedal bypasses had a significantly inferior survival rate (25.5%) compared to those with below-the-knee (27.7%; p < 0.001) and above-the-knee bypasses (31.7%; p < 0.001). Conclusion: Perioperative and long-term outcomes regarding survival and major amputation rate for CLTI patients undergoing LEB are consistently worse for DM patients compared to non-DM patients.
A Review from a Clinical Perspective: Recent Advances in Biosensors for the Detection of L-Amino Acids
Authors: Ratautė Kristina , Ratautas Dalius
Published: December 2023

The field of biosensors is filled with reports and designs of various sensors, with the vast majority focusing on glucose sensing. However, in addition to glucose, there are many other important analytes that are worth investigating as well. In particular, L-amino acids appear as important diagnostic markers for a number of conditions. However, the progress in L-amino acid detection and the development of biosensors for L-amino acids are still somewhat insufficient. In recent years, the need to determine L-amino acids from clinical samples has risen. More clinical data appear to demonstrate that abnormal concentrations of L-amino acids are related to various clinical conditions such as inherited metabolic disorders, dyslipidemia, type 2 diabetes, muscle damage, etc. However, to this day, the diagnostic potential of L-amino acids is not yet fully established. Most likely, this is because of the difficulties in measuring L-amino acids, especially in human blood. In this review article, we extensively investigate the ‘overlooked’ L-amino acids. We review typical levels of amino acids present in human blood and broadly survey the importance of L-amino acids in most common conditions which can be monitored or diagnosed from changes in L-amino acids present in human blood. We also provide an overview of recent biosensors for L-amino acid monitoring and their advantages and disadvantages, with some other alternative methods for L-amino acid quantification, and finally we outline future perspectives related to the development of biosensing devices for L-amino acid monitoring.
Profiles of Dysarthria: Clinical Assessment and Treatment
Authors: Ziegler Wolfram , Staiger Anja , Schölderle Theresa
Published: December 2023

In recent decades, we have witnessed a wealth of theoretical work and proof-of-principle studies on dysarthria, including descriptions and classifications of dysarthric speech patterns, new and refined assessment methods, and innovative experimental intervention trials [...]
Staff Perspectives in Mental Health Research Regarding Restrictive Interventions: An Australian Scoping Review and Thematic Analysis
Authors: Chavulak Jacinta , Smyth Terry , Sutcliffe Nicholas , Petrakis Melissa
Published: December 2023

Service users and their families have raised concerns about safety in current acute mental health service delivery. Restrictive interventions are routinely used across mental health settings despite increasing awareness of the negative impacts. Underfunding and risk-averse management practices are implicated as key challenges. Utilizing a scoping review and thematic analysis method, this review explored the existing literature of mental health staff perspectives across various settings (including psychiatric wards and emergency departments), focusing on their experience of restrictive interventions. Four themes were developed: 1. Safety (both staff and patient); 2. Barriers to staff reducing their restrictive interventions; 3. Strength in current practice; 4. Recommendations for change. Key gaps in the literature were the limited perspectives of emergency and crisis clinicians (despite these areas being settings where restrictive interventions are utilized) and limited perspectives from allied health disciplines (despite their employment as clinicians in these settings). It also noted a divide between staff and patient safety, as though these concerns are mutually exclusive rather than cooccurring, which is the experienced reality. Advocacy bodies, governments and the media are calling for a reduction in restrictive interventions in crisis settings. This research synthesis proposes that, to achieve this, clinical staff must be involved in the process and their perspectives actively sought and drawn upon to enable reform.
A Continuously Derivable Uniaxial Tensile Stress-Strain Model of Cold-Formed Circular Steels
Authors: Yang Chang , Ying Ling , Wang Binbin , Li Qi
Published: December 2023

Promoting prefabricated steel structures is considered one of the crucial approaches to meeting the objectives of “carbon peak” and “carbon neutrality” in the construction industry. Due to insufficient practical experience and incomplete fine engineering techniques in civil construction, the sustainable development of prefabricated building systems in China faces many challenges. Taking steel components as an example, the design process of tubular columns does not pay enough attention to the influence of the cold-working effect on material mechanical properties, and the constitutive relationship of cold-formed steels is not clear, which will cause an engineering economic burden and may affect the judgment of catastrophic problems. To serve the refined design and meet the intelligent construction technology using the computer platform, a modified Menegotto-Pinto model using a continuously derivable function is proposed in the paper. The proposed model can successfully describe the complete stress-strain curve of cold-formed circular mild steels as long as the basic mechanical parameters of the parent material are determined. Taking into account the influence of the strength and thickness of the parent steel sheets, as well as the internal bending radius r, on the cold-rolling effect, the model can also flexibly track the elastic-plastic nonlinearity of the cold-formed materials. In addition, the research shows that the cold-rolling effect will weaken with the increase of the yield strength fsy,0 of the parent steels and r/t ratio, and may disappear when fsy,0 reaches 1748 MPa or the r/t ratio is approximately 60, which can be used as economic indicators during the design process.
Assessment of the Efficiency of Eco-Friendly Lightweight Concrete as Simulated Repair Material in Concrete Joints
Authors: Youssf Osama , Roychand Rajeev , Elchalakani Mohamed , Tahwia Ahmed M.
Published: December 2023

The high production of carbon dioxide from concrete cement manufacturing and the high utilization of natural resources in concrete has been a concern for research in recent decades. Eco-friendly concrete (Eco-Con) is a type of concrete that uses less energy in its production, utilizes waste materials, produces less carbon dioxide, and is durable. This study assesses the efficiency of the proposed lightweight Eco-Con mixes with 32 MPa compressive strength in repairing different types of concrete structures. Rubber and lightweight expanded clay aggregate (LECA) were used as lightweight materials in the Eco-Con mixes. One Portland cement concrete mix (CC) and three different Eco-Con mixes, namely geopolymer rubber concrete (GR), geopolymer LECA concrete (GL), and rubber-engineered cementitious composite (RECC), were produced and compared. The concrete mixes were utilized as simulated ‘repair’ materials in several types of concrete joints, namely reinforced slab–beam joints (400 × 300 mm L-shape, 500 mm width, and 100 mm thickness) subjected to bending, concrete joints in beams (100 × 100 × 350 mm) subjected to bending, and concrete joints in unconfined and fiber-reinforced polymer (FRP) confined columns (100 mm diameter and 200 mm height) subjected to axial compression. The reinforced slab–beam joint and FRP-confined column joint were tested with two joint angles of 0° and 45°. The results indicated that RECC is an efficient lightweight Eco-Con alternative to Portland cement concrete in repairing concrete structural elements, especially beams and FRP-confined columns, as it increased their strength capacities by 43% and 190%, respectively. At the tested joint angles (0° or 45°), the use of Eco-Con mixes showed relatively lower slab–beam joint strength capacity than that of the CC mix by up to 14%. A joint angle of 45° was better than 0°, as it showed up to 7% better slab–beam joint strength capacity. Using shear connectors in slab–beam joints had adverse effects on concrete cracking and deformability.
Real-World Data Assessing the Impact of Lymphovascular Space Invasion on the Diagnostic Performance of Sentinel Lymph Node Mapping in Endometrial Cancer
Authors: Buechi Carol A. , Siegenthaler Franziska , Sahli Laura , Papadia Andrea , Saner Flurina A. M. , Mohr Stefan , Rau Tilman T. , Solass Wiebke , Imboden Sara , Mueller Michael D.
Published: December 2023

Background: SLN mapping has emerged as a standard of care in endometrial cancer due to its high sensitivity and significant reduction in morbidity. Although lymphovascular space invasion (LVSI) is a known risk factor for lymph node metastasis and recurrence, evidence on the reliability of SLN mapping in LVSI-positive patients is scarce. The aim of this study was to determine the impact of LVSI on the diagnostic performance of SLN mapping. Methods: This retrospective cohort study included patients with endometrial cancer who underwent primary surgical treatment at the Bern University Hospital, Switzerland, between 2012 and 2022. Results: LVSI was present in 22% of patients and was significantly associated with lymph node metastasis (p < 0.001) and recurrence (p < 0.001). In node-negative patients with only SLN mapping performed, LVSI was an independent predictor of recurrence during multivariable Cox regression analysis (p = 0.036). The negative predictive value of SLN mapping was 91.5% and was significantly lower in tumors with LVSI (75.0%) compared to LVSI-negative tumors (95.6%, p = 0.004). Conclusion: The presence of LVSI was significantly associated with worse oncological outcomes. LVSI was an independent predictor of recurrence in node-negative patients with only SLN mapping performed. Furthermore, the negative predictive value of SLN mapping was significantly lower in LVSI-positive tumors.
Amino Acid Profiles in the Biological Fluids and Tumor Tissue of CRC Patients
Authors: Santos Marisa Domingues , Barros Ivo , Brandão Pedro , Lacerda Lúcia
Published: December 2023

Amino acids are the building blocks of proteins and essential players in pathways such as the citric acid and urea cycle, purine and pyrimidine biosynthesis, and redox cell signaling. Therefore, it is unsurprising that these molecules have a significant role in cancer metabolism and its metabolic plasticity. As one of the most prevalent malign diseases, colorectal cancer needs biomarkers for its early detection, prognostic, and prediction of response to therapy. However, the available biomarkers for this disease must be more powerful and present several drawbacks, such as high costs and complex laboratory procedures. Metabolomics has gathered substantial attention in the past two decades as a screening platform to study new metabolites, partly due to the development of techniques, such as mass spectrometry or liquid chromatography, which have become standard practice in diagnostic procedures for other diseases. Extensive metabolomic studies have been performed in colorectal cancer (CRC) patients in the past years, and several exciting results concerning amino acid metabolism have been found. This review aims to gather and present findings concerning alterations in the amino acid plasma pool of colorectal cancer patients.
Inferior Mesenteric Artery Ligation Level in Rectal Cancer Surgery beyond Conventions: A Review
Authors: Brillantino Antonio , Skokowski Jaroslaw , Ciarleglio Francesco A. , Vashist Yogesh , Grillo Maurizio , Antropoli Carmine , Herrera Kok Johnn Henry , Mosca Vinicio , De Luca Raffaele , Polom Karol , Talento Pasquale , Marano Luigi
Published: December 2023

Within the intricate field of rectal cancer surgery, the contentious debate over the optimal level of ligation of the inferior mesenteric artery (IMA) persists as an ongoing discussion, influencing surgical approaches and patient outcomes. This narrative review incorporates historical perspectives, technical considerations, and functional as well as oncological outcomes, addressing key questions related to anastomotic leakage risks, genitourinary function, and oncological concerns, providing a more critical understanding of the well-known inconclusive evidence. Beyond the dichotomy of high versus low tie, it navigates the complexities of colorectal cancer surgery with a fresh perspective, posing a transformative question: “Is low tie ligation truly reproducible?” Considering a multidimensional approach that enhances patient outcomes by integrating the surgeon, patient, technique, and technology, instead of a rigid and categorical statement, we argued that a balanced response to this challenging question may require compromise.
Emerging Immunotherapy Approaches for Advanced Clear Cell Renal Cell Carcinoma
Authors: Meng Lingbin , Collier Katharine A. , Wang Peng , Li Zihai , Monk Paul , Mortazavi Amir , Hu Zhiwei , Spakowicz Daniel , Zheng Linghua , Yang Yuanquan
Published: December 2023

The most common subtype of renal cell carcinoma is clear cell renal cell carcinoma (ccRCC). While localized ccRCC can be cured with surgery, metastatic disease has a poor prognosis. Recently, immunotherapy has emerged as a promising approach for advanced ccRCC. This review provides a comprehensive overview of the evolving immunotherapeutic landscape for metastatic ccRCC. Immune checkpoint inhibitors (ICIs) like PD-1/PD-L1 and CTLA-4 inhibitors have demonstrated clinical efficacy as monotherapies and in combination regimens. Combination immunotherapies pairing ICIs with antiangiogenic agents, other immunomodulators, or novel therapeutic platforms such as bispecific antibodies and chimeric antigen receptor (CAR) T-cell therapy are areas of active research. Beyond the checkpoint blockade, additional modalities including therapeutic vaccines, cytokines, and oncolytic viruses are also being explored for ccRCC. This review discusses the mechanisms, major clinical trials, challenges, and future directions for these emerging immunotherapies. While current strategies have shown promise in improving patient outcomes, continued research is critical for expanding and optimizing immunotherapy approaches for advanced ccRCC. Realizing the full potential of immunotherapy will require elucidating mechanisms of response and resistance, developing predictive biomarkers, and rationally designing combination therapeutic regimens tailored to individual patients. Advances in immunotherapy carry immense promise for transforming the management of metastatic ccRCC.
Numerical Simulation of a Valorisation-Oriented Hybrid Process for the Bio-Oil-Related Separation of Acetol and Acetic Acid
Authors: Chilev Chavdar , Lamari Farida , Langlois Patrick
Published: December 2023

Biomass as a whole offers a more diverse potential for valorisation than any other renewable energy source. As one of the stages in the separation of bio-oil involves a liquid mixture of acetol and acetic acid, and as both components are particularly well suited for valorisation, a hybrid method was developed for their separation with a high purity level through an approach combining liquid–liquid extraction and distillation. In order to design and simulate the flowsheet, the ChemCAD 7.0 simulation software was used. Sensitivity analyses were carried out to investigate the influence of the different parameters in the distillation columns, such as the reflux ratio, the feed stage location, and the vapour/bottom molar flow ratio. The effect of different extractants and of their excess on the separation process, as well as the possibility of regenerating the extractant, was also studied. Tri-n-octylamine was accordingly selected as a separating agent that was fully recycled. The end result for separating an initial 48/52 wt% acetol/acetic acid liquid mixture was acetol with a purity of 99.4 wt% and acetic acid with a purity of 100 wt%.
An Unusual Presentation of Novel Missense Variant in PAX6 Gene: NM_000280.4:c.341A>G, p.(Asn114Ser)
Authors: Vasilyeva Tatyana A. , Sukhanova Natella V. , Khalanskaya Olga V. , Marakhonov Andrey V. , Prokhorov Nikolai S. , Kadyshev Vitaly V. , Skryabin Nikolay A. , Kutsev Sergey I. , Zinchenko Rena A.
Published: December 2023

This study investigates a unique and complex eye phenotype characterized by minimal iris defects, foveal hypoplasia, optic nerve coloboma, and severe posterior segment damage. Through genetic analysis and bioinformatic tools, a specific nonsynonymous substitution, p.(Asn114Ser), within the PAX6 gene’s paired domain is identified. Although this substitution is not in direct contact with DNA, its predicted stabilizing effect on the protein structure challenges the traditional understanding of PAX6 mutations, suggesting a gain-of-function mechanism. Contrary to classical loss-of-function effects, this gain-of-function hypothesis aligns with research demonstrating PAX6’s dosage sensitivity. Gain-of-function mutations, though less common, can lead to diverse phenotypes distinct from aniridia. Our findings emphasize PAX6’s multifaceted influence on ocular phenotypes and the importance of genetic variations. We contribute a new perspective on PAX6 mutations by suggesting a potential gain-of-function mechanism and showcasing the complexities of ocular development. This study sheds light on the intricate interplay of the genetic alterations and regulatory mechanisms underlying complex eye phenotypes. Further research, validation, and collaboration are crucial to unravel the nuanced interactions shaping ocular health and development.
Modeling Seasonality of Emotional Tension in Social Media
Authors: Nosov Alexey , Kuznetsova Yulia , Stankevich Maksim , Smirnov Ivan , Grigoriev Oleg
Published: December 2023

Social media has become an almost unlimited resource for studying social processes. Seasonality is a phenomenon that significantly affects many physical and mental states. Modeling collective emotional seasonal changes is a challenging task for the technical, social, and humanities sciences. This is due to the laboriousness and complexity of obtaining a sufficient amount of data, processing and evaluating them, and presenting the results. At the same time, understanding the annual dynamics of collective sentiment provides us with important insights into collective behavior, especially in various crises or disasters. In our study, we propose a scheme for identifying and evaluating signs of the seasonal rise and fall of emotional tension based on social media texts. The analysis is based on Russian-language comments in VKontakte social network communities devoted to city news and the events of a small town in the Nizhny Novgorod region, Russia. Workflow steps include a statistical method for categorizing data, exploratory analysis to identify common patterns, data aggregation for modeling seasonal changes, the identification of typical data properties through clustering, and the formulation and validation of seasonality criteria. As a result of seasonality modeling, it is shown that the calendar seasonal model corresponds to the data, and the dynamics of emotional tension correlate with the seasons. The proposed methodology is useful for a wide range of social practice issues, such as monitoring public opinion or assessing irregular shifts in mass emotions.
A New Method for Proportioning Sustainable, Economic, and Resilient Concrete
Authors: Vasudevan Gokul Dev , Vaddey Naga Pavan , Trejo David
Published: December 2023

The ordinary Portland cement (OPC) component of concrete is the highest contributor to concrete’s cost and carbon footprint. Historically, code-writing organizations have required a high volume of paste in concrete mixtures by imposing minimum limits on the OPC content for a given application. However, high paste contents can result in dimensional instability, higher costs, higher carbon footprints, and lower durability. Minimizing the OPC content in concrete can provide economic, durability, and sustainability benefits. This study hypothesizes that the amount of OPC required to achieve some required fresh and hardened characteristics is highly dependent on the aggregate characteristics, supplementary cementing material (SCM) characteristics, and proportions of these. Given this, this research proposes using the amount of voids in the aggregate system (AV), or more specifically the paste volume-to-aggregate void ratio (PV/AV); SCM reactivity; and the SCM replacement level as key parameters to proportion concrete mixtures with minimum OPC contents to meet sustainability, economic, and resilience (SER) requirements. A new mixture proportioning procedure, referred to here as the SER proportioning method, is developed in this study based on assessing AV and identifying an optimal PV/AV that satisfies the required concrete characteristics. The results show that implementing the SER mixture proportioning method and including SCMs, or more specifically off-spec fly ashes (OFAs), can lead to significant reductions in the paste content and associated reductions in the cost and embodied carbon footprint of concrete.
Polymorphism in S(+)Clopidogrel-Picrate: Insights from X-ray Diffraction, Vibrational Spectroscopy, Thermal Analysis, and Quantum Chemistry
Authors: Cvetkovski Aleksandar , Makreski Petre , Pejov Ljupcho , Stojanovska Pecova Monika , Bertolasi Valerio , Gilli Paola , MacGillivray Leonard R.
Published: December 2023

The crystal structures of two pseudopolymorphic forms of S(+)clopidogrel–picrate are reported. Form 1 crystallizes in the monoclinic space group P21 with an ionic couple S(+)ClopH+·Pic− and a molecule of solvent ethanol in the asymmetric unit, while Form 2 crystallizes in the monoclinic space group C2 with two ionic couples in the asymmetric unit. The configurations and conformations of the ionic couples, held together by ionized +N-H···O hydrogen bonds, are nearly identical in the structures. The self-assembly properties are compared with reported clopidogrel salts, including those used in pharmaceutical formulations. The hydrogen bonds are discussed in reference to the general corresponding behavior of the N-bases picrates and the properties of the acid-base coformers. The preparations of the pseudopolymorphs were optimized toward two different methods: solvent evaporation and mechanochemical treatment. Reproducibility to generate the single crystalline phases was confirmed by thermal and vibrational spectroscopic properties. Periodic third-order density-functional tight binding (DFTB3) calculations predict rather small energy difference between the two pure phases of polymorphs 1 and 2. However, the included solvent molecules in Form 1 decrease the lattice energy for ~10.5 kcal mol−1, which leads to a lower ΔElatt. lattice energy in comparison to Form 2 (by ~7.3 kcal mol−1). All predicted trends are in line with the experimentally observed formation of Form 1 instead of its simulated non-solvated Form 1.
Production of Stable Flies (Stomoxys calcitrans) from Sawdust Compost Barns and Straw Bedding Packs, Two Alternative Cold Winter Housing Systems for Dairy Cows
Authors: Hansen Anna C. , Moon Roger D. , Endres Marcia I. , Heins Bradley J.
Published: December 2023

Stable flies, Stomoxys calcitrans (L.), are important biting pests of dairy cattle and other livestock. These flies develop in decaying organic matter, such as soiled animal bedding. As part of a larger study of management options in organic dairy production, leftover debris from two winter housing systems, outdoor straw packs and indoor sawdust compost barns, were analyzed for the numbers and size of stable flies produced the following summer. The study was conducted at the University of Minnesota’s West Central Research and Outreach Center in Morris. During winter, independently managed groups of 20 cows were housed from November to May in replicate housing systems. After the cows were moved to summer pasture, fly traps were assembled in the leftover piles (n = 4): emergence traps to quantify stable fly emergence and Olson traps to study ambient adults. The size of the emerged flies and 30 ambient adult females were measured. The sampled females were also dissected to determine the gonotrophic age. During peak emergence in both years, straw piles produced significantly more stable flies than compost bedding, but the adults were equal in size. The Olson traps showed adults were equally abundant at both sources. Over 60% of the females dissected were previtellogenic, indicating local emergence. Compost bedding is useful in managing stable fly numbers, while straw presents a serious stable fly production liability if not disposed of properly.
Three-Dimensional Analysis of the Cranial Base Structure in Patients with Facial Asymmetry
Authors: Hayashi Yuki , Tachiki Chie , Morikawa Taiki , Aihara Yasuo , Matsunaga Satoru , Sugahara Keisuke , Watanabe Akira , Kawamata Takakazu , Nishii Yasushi
Published: December 2023

Facial asymmetry is often seen in patients with skeletal mandibular prognathism and is associated with deformities in the maxillofacial and head regions. The maxillofacial deviation is three-dimensional and affects not only the lateral deviation of the mandible and midface, but also the cranium. This study conducted a three-dimensional morphological evaluation of the cranial base morphology of patients with skeletal mandibular prognathism (ANB < 0°, Wits < 0 mm) with the aim of examining the relationship between deformities of the head region and facial asymmetry. Data obtained from computed tomography conducted during the initial examination of patients with and without skeletal mandibular prognathism with facial asymmetry were used. Differences in the position of structures present in the cranial base were measured, and the association between cranial deformities and mandibular deviation was assessed. The middle cranial base area and the lateral deviation of the mandibular fossa were significantly larger in patients with facial asymmetry compared to those without facial asymmetry. In addition, a correlation between the amount of mandibular deviation and the area of the anterior cranial base was identified in patients with significant cranial deformity (p = 0.012). Given the identified association between the structure of the head region and facial asymmetry, further studies are needed to determine the factors implicated in the growth process.
Vaccine Hesitancy in Israel: Exploring the Relationships with Vaccination History, Knowledge, and Attitudes towards Influenza Vaccines
Authors: Dopelt Keren , Yukther Sophie , Shmukler Tatyana , Abudin Anuar
Published: December 2023

Influenza vaccination is a highly effective strategy for mitigating all the repercussions of influenza infections. Despite the potential severity of influenza and the accessibility of secure vaccinations, worldwide rates of influenza vaccination continue to be low, particularly among students. This study examines the correlative relationships between influenza vaccine history, knowledge, attitudes toward influenza vaccines, and vaccine hesitancy among college students. To that end, we used an online questionnaire to conduct a cross-sectional study encompassing 610 students. A significant majority of participants reported having experienced influenza (82%), with slightly more than half having received influenza vaccinations in the past (57%). With respect to the current research year, health sciences students exhibited a higher likelihood of either having been vaccinated or intending to receive the vaccine than did their counterparts. Among students who had been vaccinated previously, approximately one-fifth opted for vaccination in the present year (21%). Similarly, 22% of the students whose parents were vaccinated chose to get vaccinated this year. Notable disparities in knowledge about influenza vaccines were observed across various departments, with health sciences students demonstrating the highest levels of awareness. Moreover, a negative relationship was found between knowledge, attitudes, and vaccine hesitancy. These results suggest that targeted lectures by professionals emphasizing vaccine safety and university-hosted events addressing this subject in collaboration with the Ministry of Health, incorporating influenza vaccination stations, could be instrumental in bolstering the vaccination rate.
Geosmin and 2-Methylisoborneol Detection in Water Using Semiconductor Gas Sensors
Authors: Szczurek Andrzej , Maciejewska Monika , Kabsch-Korbutowicz Małgorzata , Wolska Małgorzata , Solipiwko-Pieścik Anna
Published: December 2023

Geosmin and 2-methylisoborneol (MIB) are the most common causes of unpleasant odours in drinking water. A method was proposed to detect and recognise these compounds in water and determine their concentrations. The method utilises commercial solid-state gas sensors and data analysis. Sample preparation plays an important role. The aqueous solution is converted into a gas sample using a specially designed dynamic headspace. The responses of the sensors are recorded during exposure to headspace vapours in a dynamic mode. The best limit of detection for geosmin, LOD = 6.20 µg/L, was attained with a TGS2602 sensor. The best limit of detection for MIB, LOD = 0.52 µg/L, was attained with a TGS826 sensor. Geosmin and MIB recognition was 100% successful based on TGS826 and TGS2602 response classifications. Geosmin and MIB concentrations were effectively determined in solutions containing one or both compounds. The respective mathematical models utilised the responses of TGS826 and TGS2602. The smallest concentration prediction error was RMSE = 2.19 µg/L (for geosmin) and RMSE = 0.33 µg/L (for MIB). The study demonstrated the application potential of non-specific gas sensors for the early warning monitoring of geosmin and MIB presence in water. Further studies are needed to develop a system that can be tested in field conditions.
Evaluation of Single Event Upset on a Relay Protection Device
Authors: Zhou Hualiang , Yu Hao , Zou Zhiyang , Su Zhantao , Zhao Qianyun , Yang Weitao , He Chaohui
Published: December 2023

Traditionally, studies have primarily focused on single event effects in aerospace electronics. However, current research has confirmed that atmospheric neutrons can also induce single event effects in China’s advanced technology relay protection devices. Spallation neutron irradiation tests on a Loongson 2K1000 system-on-chip based relay protection device have revealed soft errors, including abnormal sampling, refusal of operation and interlock in the relay protection device. Given the absence of standardized evaluation methods for single event effects on relay protection devices, the following research emphasizes the use of Monte Carlo simulation and software fault injection. Various types of single event upsets, such as single bit upsets, dual bit upsets, and even eight bit upsets, were observed in Monte Carlo simulations where atmospheric neutrons hit the chip from different directions (top and bottom). The simulation results indicated that the single event effect sensitivity of the relay protection device was similar whether the neutron hit from the top or the bottom. Through software fault injection, the study also identified soft errors caused by neutron induced single event upsets on the Loongson 2K1000 system, including failure to execute, system halt, time out, and error result. And the soft error number of system halts and error results exceeded that of time outs and failures to execute in all three tested programs. This research represents a preliminary assessment of single event effects on relay protection devices and is expected to provide valuable insights for evaluating the reliability of advanced technology relay protection devices.
A UAV Path Planning Method in Three-Dimensional Space Based on a Hybrid Gray Wolf Optimization Algorithm
Authors: Feng Jianxin , Sun Chuanlin , Zhang Jianhao , Du Yue , Liu Zhiguo , Ding Yuanming
Published: December 2023

Path planning, which is needed to obtain collision-free optimal paths in complex environments, is one key step within unmanned aerial vehicle (UAV) systems with various applications, such as agricultural production, target tracking, and environmental monitoring. A new hybrid gray wolf optimization algorithm—SSGWO—is proposed to plan paths for UAVs under three-dimensional agricultural environments in this paper. A nonlinear convergence factor based on trigonometric functions is used to balance local search and global search. A new relative-distance fitness adaptation strategy is created to increase the convergence speed of the SSGWO. Integrating the simulated annealing (SA) algorithm, an alternative position update strategy based on SA is proposed to improve the search process with diverse capabilities. Finally, a B-spline curve is introduced into a smooth path to ensure the path’s feasibility. The simulation results show that the SSGWO algorithm has better convergence accuracy and stability, and can obtain higher-quality paths in a three-dimensional environment, compared with GWO, MGWO, IGWO, and SOGWO.
Indoor Sound Source Localization via Inverse Element-Free Simulation Based on Joint Sparse Recovery
Authors: Wang Haitao , He Qunyi , Peng Shiwei , Zeng Xiangyang
Published: December 2023

Indoor sound source localization is a key technique in many engineering applications, and an inverse element-free method based on joint sparse recovery in a Bayesian framework is proposed for reverberant environments. In this method, a discrete wave model is constructed to represent the relationships between the sampled sound pressure and the source intensity distribution, and localization in the reverberant environment is realized via inversion from the wave model. By constructing a compact supporting domain, the source intensity can be sparsely represented in subdomains, and the sparse Bayesian framework is used to recover the source intensity. In particular, joint sparse recovery in the frequency domain is exploited to improve the recovery performance. Numerical and experimental verifications show that, compared with another state-of-the-art method, the proposed method achieves high source-localization accuracy and low sidelobes with low computational complexity in highly reverberant environments.
A Hierarchical Driving Control Strategy Applied to Parallel SiC MOSFETs
Authors: Luo Yin , Tang Xiaoyan , Sun Shikai , Liu Jialin , Yang Wenhao , Sun Yuyin
Published: December 2023

SiC (silicon carbide) MOSFETs have been extensively used in the power electronics industry due to their exceptional characteristics. First, it was found in this study that their driving loss is larger than their conduction loss in high-frequency applications. Based on this finding, this study proposes a hierarchical driving control strategy for improving the parallel-converter efficiency of SiC MOSFETs under light loads. Efficiency under light loads is of great importance for battery-based energy storage systems. To minimize the sum of the conduction loss and driving loss in parallel devices, this study proposes a current-monitoring hierarchical driving strategy based on an active-clamped flyback converter. By monitoring the output current of the converter, the strategy minimizes the sum of the driving and conduction losses by switching the driving state under different loads. The results of simulations indicate the effectiveness of the load-current-monitoring strategy. To verify the effectiveness of this method, a principle prototype of two SiC MOSFETs connected in parallel at 12 V/5 A was fabricated and tested, and the test results showed that there was a maximum improvement of 1.4% in the converter’s efficiency when the load current was in the range of 0.5–1.5 A.
Maxwell’s Early Unitary View of Electricity and Fluid Mechanics
Authors: Tripodi Giulia , Ruta Giuseppe
Published: December 2023

In young Maxwell’s eyes, electricity, magnetism and fluid mechanics present analogies that let the first be mathematically grasped in a unitary way similarly to the latter. This entry sketches the first steps of James Clerk Maxwell’s unitary view of electromagnetism and fluid mechanics, with long-lasting effects on understanding the physical world. In his very first paper on the subject, Maxwell interpreted Faraday’s concept of lines of force of both electricity and magnetism as filaments of a flowing fluid. That is, Maxwell suggested to unify the previously distinct fields of electricity and magnetism, considering them as different aspects of the same entity, the ‘electromagnetic field’, which is mathematically described by four partial differential equations. In the literature there are several comprehensive works on Maxwell’s mature exposition of his theory; however, the aim of this entry contribution is rather more limited. Indeed, it is restricted to examining the contributions of Maxwell’s first paper towards developing the idea of electric current as the motion of an incompressible fluid. Thus, this entry highlights the strong connections of Maxwell’s epistemological view with the ‘mechanistic’ approach of the time to every aspect of physical phenomenology. For this purpose, this entry mentions some historical context surrounding the emergence of Maxwell’s innovative concepts.
Fine-Scale Spatial Variability of Stand Structural Features under Selection Management and Strict Protection: An Example from the Dinaric Mountains
Authors: Keren Srdjan , Ochał Wojciech , Dukić Vojislav
Published: December 2023

Small scattered plots of a few hundred square meters well reflect structural variability at stand level, but not at small spatial scales as the data between plots is missing. Information about structural similarities between managed and unmanaged stands, especially based on large sample plots, is still scarce. Our first objective was to quantify and illustrate structural variability of a selection-managed stand and a corresponding old-growth (OG) stand at small spatial scales. The second goal was to find out if there is a positive autocorrelation among neighboring patches in these stands regarding tree density (N) and basal area (BA). Tree positions and their diameters were recorded in 1.5 ha plots. Structural variation was examined at scales from 0.01 ha to 0.36 ha. Spatial correlation of N and BA was examined by applying experimental semivariograms. The variability of N was similar in both stands, whereas it significantly differed regarding BA (α = 0.05). Semivariance did not detect positive spatial autocorrelation of BA, while adjacent plots appeared to be more similar (autocorrelated) regarding N in both stands. Despite statistical difference regarding BA variability, the selection-managed stand exhibited many structural similarities to the OG stand, which makes it potentially suitable for modulating, if needed, to bring it step closer to an old-growth structure.
Spatiotemporal Dynamics of Betula pendula Crown Cover on Abandoned Arable Land in a Broad-Leaved Forest Zone of Bashkir Cis-Ural
Authors: Fedorov Nikolay , Tuktamyshev Ilshat , Bikbaev Ilnur , Shirokikh Pavel , Zhigunova Svetlana , Baisheva Elvira , Martynenko Vasiliy
Published: December 2023

Silver birch (Betula pendula Roth) is one of the fast-growing tree species that often colonize abandoned agricultural lands in Europe and the European part of Russia. The purpose of this article is to analyze the spatiotemporal dynamics of Betula pendula crown cover on abandoned arable lands in a zone of broad-leaved forests of the Bashkir Cis-Ural (Russia, Republic of Bashkortostan). The assessment of current and retrospective values of crown cover was carried out using a regression model of the dependence of crown cover on the values of red channel brightness in early-spring images from Landsat 5–8 and Sentinel-2 satellites from 2012–2022. To estimate the number and height of trees, a survey was carried out using a LiDAR camera mounted on a UAV. After calculating the crown cover in grid squares and their distance from the seed source in QGIS, variance analysis was carried out to assess the influence of the factor of distance from the seed source on the crown cover. The influence of the factor of distance from the seed source on the crown cover was higher at earlier stages of overgrowth of abandoned agricultural lands. An exception to this dependence was only one sample plot where the prevailing wind direction was opposite to the direction of seed dispersal. The leading factors affecting the distribution of birch on abandoned agricultural lands were wind direction, height of seed trees, and grazing. In the parts of the sample plots that were furthest away from seed sources, the trees were 1–3 years younger or the same age, and stand density was lower than in sites located closer to the seed trees. In general, the results of the present study indicate two opposite relationships between seedling survival and distance to seed trees: (1) seed fall and seedling density decrease with increasing distance from the seed tree, and (2) the probability of seed/seedling survival increases due to decreased competition.
Cassava Bagasse as a Low-Cost Substrate for Cellulase and Organic Acid Production Using Co-Cultivated Fungi
Authors: Farniga Analdi , Khaokhajorn Phimrak , Wattanachaisaereekul Songsak
Published: December 2023

Cassava bagasse has great potency as a substrate in the biorefinery industry. This paper proposes the valorisation of cassava bagasse into organic acids by cellulase through the co-cultivation of Aspergillus violaceofuscus and Trichoderma reesei RUT-C30 at the ratio 1:1. The optimised conditions for β-glucosidase production under submerged fermentation were pH 4.50, a tween 80 concentration of 0.05% (v/v), and a spore concentration of 7.18 × 107 spores·mL−1. We found base steam cassava bagasse (BSCB) to have high cellulose content, making it possible to replace avicel phosphoric acid swollen cellulose (PASC) as a substrate. The co-cultivation with the BSCB substrate had higher levels of β-glucosidase (1.72-fold), cellobiohydrolase (2.83-fold), and endoglucanase (2.82-fold) activity compared to that of the avicel PASC substrate. Moreover, acetic acid (7.41 g·L−1), citric acid (3.54 g·L−1), gluconic acid (0.30 g·L−1), and malic acid (0.37 g·L−1) were detected in the BSCB crude extract. These results demonstrate the considerable prospects of the A. violaceofuscus and T. reesei RUT-C30 co-cultivation approaches in the biorefinery industry.