bluuebunny/crossref_metadata_2025 huggingface dataset:
High-dose methotrexate therapy for a child with B-cell precursor acute lymphoblastic leukemia and congenital solitary kidney
Authors: Hokama Noboru , Hyakuna Nobuyuki , Hamada Satoru , Shiohira Hideo , Nakanishi Koichi , Nakamura Katsunori
Published: January 2024

High-dose methotrexate (HD-MTX) is a key drug in the treatment of
various cancers. Massive fluid infusion is necessary during HD-MTX
therapy to ensure proper methotrexate excretion. There are no reports on
the safety of HD-MTX therapy in patients with congenital solitary kidney
(CSK). A 5-year-old male child with CSK and B-cell precursor acute
lymphoblastic leukemia was treated with four cycles of HD-MTX therapy.
HD-MTX therapy was safely administered without delayed MTX excretion or
renal dysfunction. This case showed that HD-MTX therapy was well
tolerated by a pediatric patient with CSK.
Prevalence and characteristics of a novel feline parvovirus-like virus in dogs in China
Authors: Tang Cheng , Wang Jiali , Chen Xi , Zhou Yuxing , Yue Hua , Zhou Ning , Gong Hongyi
Published: January 2024

Canine parvovirus (CPV) infection is one of the most dangerous
infectious diseases in young puppies worldwide. In this study, 192
diarrheal fecal samples were collected from
2019.4~2021.6 for monitoring the molecular prevalence of
CPV among dogs by a specific PCR targeted VP2 gene in Southwest China,
and 113 samples were detected as parvovirus-positive. Surprisingly,
28/113 (24.8 %) parvovirus-positive strains were identified as feline
parvovirus (FPV)-like strains based on the evolutionary analysis of the
567 bp VP2 fragments which contain the aa residue of VP2 323D typical
for FPV. To gain insights into the molecular and biological
characteristics of these FPV-like viruses in dogs, 6 FPV-like strains
were successfully isolated and genome sequenced. Analysis of genomic
sequences suggested that the 6 isolates can represent a novel parvovirus
in dogs, named FPV-like-1, which have the following characteristics: a.
The genomic nucleotide (nt) and individual proteins are most genetically
related with FPV instead of CPV. b. The VP2 proteins contain all unique
amino acid (aa) residues typical for FPV. c. Compared with the FPV, the
VP1 intron and NS1 exhibit some identical unique mutations. These
FPV-like-1 strains could hemagglutinate swine erythrocyte at a broad
range of PH values between 6.0 and 8.0 and replicate efficiently in MDCK
cell line. Moreover, these isolates caused canine systemic infection via
oral administration. Analysis of VP2 sequences of CPV available in
GenBank revealed that the FPV-like strains had already existed in five
countries of China, Vietnam, Pakistan, Thailand, Australia, and have
circulated widely among dogs in China.
The fitness optimization strategy under simulated warming An exploration on the reproductive pattern of the clonal submerged plant, Potamogeton crispus L.
Authors: Wang Tong , Yang Liyu , Fang Lizheng , Wang Chunlin , Yu Dan , Li Haifang
Published: January 2024

Reproduction determines the fitness and is a crucial component of life
history. Asexual and sexual reproduction synergistically contribute to
the fitness of clonal plants. Extreme warming leads to a periodical
sharp rise in temperature and may affect the plant fitness. Few studies
have concerned the impacts of extreme warming on the reproductive
pattern of clonal aquatic plant and its evolutionary implication. In the
present study, the cosmopolitan clonal submerged plant species,
Potamogeton crispus L. from four different geographic sources, was
subjected to simulated extreme warming. Both asexual and sexual
reproductive performances including the recruitment of turions and
fruits were evaluated. We found that both geographic source and warming
significantly affected the reproductive performances. Although the
response of turion number to warming was different for populations from
different geographic sources, the turion mass did not decrease under
warming. Moreover, warming induced a lower percentage of oligophyllous
turions – the turion with no more than four scale leaves each, and a
higher percentage of pleiophyllous turions – the turion with more than
four scale leaves each. Additionally, warming caused a complete loss of
sex for three populations. As the scale leaf functions as storage and
photosynthetic organ and the scale leaf number is positively correlated
with the axillary bud number, P. crispus may select to enhance the
sprouting potential of turion to achieve the fitness optimization by
enhancing the recruitment of scale leaves and thus larger turions under
warming.
The use of a gradient-based iterative technique to solve the generalized coupled Sylvester matrix equations over generalized centro-symmetric matrices
Authors: El-Sharwaya Marwa , Ramadan Mohamed , El-Shazly Naglaa
Published: January 2024

In this paper, the generalized coupled Sylvester matrix equations are
solved using a gradient-based iterative technique over the generalized
centro-symmetric matrices ( . In the case that our investigated matrix
equations are consistent, with chosen initial generalized
centro-symmetric matrices and , a generalized centro-symmetric solution
( can be found in a finite number of iterations in the absence of
round-off errors. Numerical examples are presented in order to support
the theoretical results of this paper.
Timeline to collapse
Authors: Cerini Francesco , Childs Dylan , Clements Christopher
Published: January 2024

Contemporary rates of biodiversity decline emphasize the need for
reliable ecological forecasting, but cur-rent methods vary in their
ability to predict the declines of real-world populations. Acknowledging
that stress acts at the individual level, and that it is the sum of
these individual-level effects which drives popu-lations to collapse,
shifts the focus of predictive ecology away from using predominantly
abundance data. Doing so opens new opportunities to develop predictive
frameworks which utilize increasingly available multi-dimensional data
which have previously been overlooked for ecological forecasting. Using
this ra-tional, we propose that stressed populations will exhibit a
predictable sequence of detectable changes through time: (i) changes in
individuals’ behaviour will occur as the first sign of increasing
stress, followed by (ii) changes in fitness related morphological
traits, (iii) shifts in the dynamics (e.g. birth rates) of popu-lations,
and finally (iv) abundance declines. We discuss how monitoring the
sequential appearance of these signals supplies information to discern
whether a population becoming increasingly stressed risks collapse or is
adapting in the face of environmental change. Such a timeline of signals
provides a new framework to implement forecasting methods combining
multidimensional data (e.g. behaviour, morphology, abun-dance) that may
increase the ability to predict population collapse.
Genetic diversity of the root-knot nematode Meloidogyne graminicola in rice (Oryzasativa L.) based on mitochondrial COI gene
Authors: Shao Hudie , Liu Mao-Yan , Huang Wen-Kun , Li Cai-Hong , Peng Deliang , Peng Huan , Li Chuan-ren , Long Hai-Bo , Kong Ling-An , Liu Shiming , zhang pan , Yu Jing-Wen , Ping Jia-jian
Published: January 2024

The root-knot nematode Meloidogyne graminicola is an important parasitic
nematode that causes huge economic losses to rice production in China.
In the present study, 54 M. graminicola populations were collected from
the major rice-growing areas of ten provinces in China. The cytochrome
oxidase subunit I (COI) gene sequence of M. graminicola populations in
the studied locations were PCR-amplified, sequenced, and evaluated for
genetic diversity analysis. The total number of mutations, haplotypes
(Hap) numbers, the average number of nucleotide differences (k),
haplotype diversity (Hd), and nucleotide diversity (π) of mtCOI gene
were 39, 15, 5.37, 0.646, and 0.00682, respectively. The significant
differences in Fst value (0.593) and a low level of gene flow (0.333)
were detected between the 54 M. graminicola populations. High genetic
diversity was observed within each population and a small genetic
distance was found between them. The phylogenetic analyses showed that
54 M. graminicola populations were divided into three large groups
corresponding to the Central Region (CR), Southern China (SC) and the
Yangtze Valley (YV). Hap8 was the most widely distributed and was
considered to be an origin of haplotype, revealing a separate
evolutionary origin in China. The high genetic differentiation of M.
graminicola populations was result of variation within each of the
defined geographical groups, according to an analysis of molecular
variance. No significant relationship was observed between the genetic
distance and geographical distance in M. graminicola populations. To the
best of our knowledge, this is the first study conductedon the genetic
diversity of M. graminicola infesting rice in China and provides a
theoretical basis for the future management of the M. graminicola
population and potential approach for increasing production of rice.
ACUTE LYMPHOBLASTIC LEUKAEMIA OCCURRED 21 YEARS AFTER A FIRST DIAGNOSIS IN A DOWN SYNDROME PATIENT SUCCESFULLY TREATED WITH BLINATUMOMAB
Authors: Rizzo Lorenzo , Chiaretti Sabina , Starza Irene Della , Taherinasab Akram , Novi Lucia Anna De , Cazzaniga Giovanni , Songia Simona , Propris Maria Stefania De , Moleti Maria Luisa , TESTI Anna Maria , foà robin
Published: January 2024

Down syndrome (DS) acute lymphoblastic leukemia (ALL), more frequent in
pediatric age than in adulthood, still have a worse outcome compared
with non-DS population, mainly due to their intrinsic susceptibility to
chemotherapeutic drugs toxicity. Furthermore, in the last years, it has
been shown that the overexpression of CRLF2 and a Ph-like signature are
relatively more frequent in DS patients. We report a case of a DS
patient who developed a Ph-like ALL, 21 years after a first diagnosis of
B-ALL, successfully treated with blinatumomab after failure of
conventional chemotherapy.
Anatomic variations of the paranasal sinus area in pediatric chronic rhinosinusitis with nasal polyps
Authors: Jiang Lijie , Zeng Yinhui , tang yiquan , zeng qingxiang , Shi Jianbo , liu wenlong
Published: January 2024

Abstract objectives: We aimed to report the prevalence of anatomic
variations in Chinese pediatric patients with chronic rhinosinusitis
with nasal polyps (CRSwNP) and to explore the correlation between
anatomic variations and the extent of chronic sinusitis in children.
Design: This retrospective study conducted between January 2018 and June
2020. Setting:This study involved children from the First Afﬁliated
Hospital, Sun Yat-sen University and Guangzhou Women and Children’s
Medical Center. Participants: Participants included 50 children with
CRSwNP. Main outcome measures: The diagnosis of CRSwNP was based on
symptoms, endoscopy, and computed tomography examination according to
European criteria on chronic rhinosinusitis. The presence of anatomical
variations was determined, and its correlation with disease extension
was analyzed. Results: Fifty children were included in the study. The
anterior ethmoid sinus was the most commonly affected sinus in children,
followed by the maxillary, posterior ethmoid, frontal, and sphenoid
sinuses. Agger nasi cells were the most common anatomic variation in
children sinus (96%), followed by inferior turbinate hypertrophy
(60%), septal deviation (55.1%), concha bullosa (45.8%), Onodi cells
(44.9%), Haller cells (38%), and paradoxical middle turbinate (4%).
No significant correlation was found between anatomic variation and
corresponding sinusitis hypertrophy and maxillary sinusitis (P
> 0.05). Conclusions: Our results found no correlation
between anatomic variations and sinusitis in pediatric CRSwNP. The
occurrence of pediatric CRSwNP is as attributed more to immunological,
infectious, or other factors rather than anatomic variations.
Maximal First Zagreb Index Of Trees With Given Roman Domination Number
Authors: Du Zhibin , Jamri Ayu Ameliatul Shahilah Ahmad , Hasni Roslan , Mojdeh Doost Ali
Published: January 2024

The first Zagreb index of graphs is defined to be the sum of squares of degrees of all the vertices of graphs. It drew a great deal of attention in the past half-century.
In this paper, we study the relationship between the first Zagreb index and Roman domination number of graphs. More precisely, we characterize the trees with maximum the first Zagreb index among trees with given Roman domination number.
Least Squares Estimation of Parameters for Uncertain Delay Differential Equations
Authors: Zhang Jing , Sheng Yuhong
Published: January 2024

Uncertain delay differential equations are a class of uncertain
differential equations with time delay, which are widely used in
population model, disease model, biological model, etc. How to estimate
uncertain delay differential equations with unknown parameters is an
important problem to be solved. Based on observed data, this paper uses
least square estimation method to obtain estimated value of unknown
parameters in the coefficients of uncertain delay differential
equations. Numerical examples are introduced to show that least squares
estimation method is suitable for uncertain delay differential
equations. Application of uncertain SIS epidemic model with time delay
further illustrates effectiveness of the method.
Vertical transmission and humoral immune response following maternal infection with SARS-CoV-2 - A prospective multicenter cohort study
Authors: Massalha Manal , Yefet Enav , Rozenberg Orit , Soltsman Sofia , Hasanein Jamal , Smolkin Tatiana , Alter Adi , Perlitz Yuri , Nachum Zohar
Published: January 2024

Objective: To explore maternal humoral immune responses to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the rate
of vertical transmission. Design: A prospective cohort study. Setting:
Two university-affiliated medical centers in Israel. Population: Women
positive for SARS-CoV-2 reverse-transcription-polymerase-chain-reaction
(RT-PCR) test, during pregnancy were enrolled just prior to delivery.
Methods: Levels of anti-SARS-CoV-2 spike-IgM, spike-IgG and
nucleocapsid-IgG were tested in maternal and cord blood at delivery, and
neonatal nasopharyngeal swabs were subjected to PCR testing. Main
outcomes measures: The primary endpoint was the rate of vertical
transmission, defined as either positive neonatal IgM, positive neonatal
IgG with sero-negative mother or positive neonatal PCR. Results: Among
72 women, 36 (50%), 39 (54%) and 30 (42%) were positive for
anti-spike-IgM, anti-spike-IgG and anti-nucleocapsid-IgG, respectively
(p<0.0001 for IgG antibodies-comparison). At least 8/72 (11%)
neonates were infected in utero; one had a positive PCR result and seven
had positive IgG antibodies while their mothers were seronegative for
the same IgG. IgM was not detected in cord blood. Anti-nucleocapsid-IgG
and anti-spike-IgG were detected in 83% and 85% of neonates of
seropositive mothers, respectively (Pearson coefficient correlation 0.8,
p<0.001). The highest rate of positive maternal serology tests
was 8-12 weeks post-infection (89% anti-spike IgG, 78% anti-spike-IgM
and 67% anti-nucleocapsid-IgG). Thereafter, the rate of positive
serology tests declined gradually; at 20 weeks post-infection, only
anti-spike-IgG was detected in 33-50%. Conclusions: The rate of
vertical transmission was at least 11%. Vaccination should be
considered 3 months post-infection in pregnant women due to a decline in
antibody levels.
Positive feedback to global warming linked to indirect nitrogen attenuation of Arctic tundra CH4 oxidation
Authors: Lee Jaehyun , Yun Jungeun , Yang Yerang , Jung Ji Young , Lee Yoo Kyoung , Yuan Junji , Ding Weixin , Freeman Chris , Kang Hojeong
Published: January 2024

CH4 oxidation in Arctic soil plays a crucial role in Arctic CH4 dynamics
whereby up to 90% of CH4 produced in soils can be removed. Previous
studies have noted the influence of temperature rise on CH4 oxidation,
but effects of inorganic nitrogen (N) have been less studied because the
Arctic is typically N-limited. However, climate change-induced increases
in available N have been reported recently, which may drastically change
CH4 oxidation in Arctic soils. Here, we show that excessive levels of
soil available N increase net CH4 emissions by attenuating soil CH4
oxidation in Arctic tundra. In-vitro experiments proved consistent with
NO3− being responsible for the decrease in CH4 oxidation, leading us to
propose that NO3− indirectly inhibits CH4 oxidation by reducing
bacterial diversity, a previously unrecognized mechanism. We provide
evidence that increased available N can enhance CH4 emissions in Arctic
tundra, with profound implications for modeling CH4 dynamics in Arctic.
Improving access to emergency obstetric care in underserved rural Tanzania
Authors: Nyamtema Angelo , Scott Heather , LeBlanc John , Kweyamba Elias , Bulemela Janet , Shayo Allan , Kilume Omary , Abel Zabron , Mtey Godfrey
Published: January 2024

Objective To describe the results of improving availability of, and
access to emergency obstetric care (EmOC) services in underserved rural
Tanzania. Design Prospective cohort study Settings Rural Tanzania
Methods Forty two associate clinicians from five health centres were
trained in teams for three months in emergency obstetric care and
anaesthesia. Two health centres were unexposed to the intervention and
served as controls. Following training, virtual teleconsultation,
quarterly on-site supportive supervision and continuous mentorship were
implemented to reinforce skills and knowledge. Main outcome measures
Proportion of all births in emergency obstetric care facilities, met
need for EmOC and case fatality rate. Results The met need for EmOC
increased significantly from 45% (459/1,025) at baseline (July 2014 –
June 2016) to 119% (2,010/1,691) during the intervention period (Jul
2016 – June 2019). The met need for EmOC in the control group also
increased from 53% (95% CI 49%-58%) to 77% (95% CI 74%-80%).
Forty maternal deaths occurred during the baseline and intervention
periods in the control and intervention health centres. The direct
obstetric case fatality rate decreased slightly from 1.5% (95% CI
0.6%–3.1%) to 1.1% (95% CI 0.7%–1.6%) in the intervention group
and from 3.3% (95% CI 1.2%–7.0%) to 0.8% (95% CI 0.2%–1.7%) in
the control group. Conclusions When EmOC services are made available the
proportion of obstetric complications treated in the facilities
increases. However, the effort to scale up EmOC services in underserved
rural areas should be accompanied by strategies to reinforce skills and
the referral system.
ANALYSIS OF THE EFFECT OF RELAPSE FOR EPIDEMIC MALARIA TRANSMISION DESEASE USING STOCHASTIC SIRS MODEL IN KOLA DIBA, NORTH GONDAR, NORTHWEST ETHIOPIA
Authors: Alemu Sewmehon
Published: January 2024

The objective of this study is to analyze the dynamics of malaria
transmission and show how relapse affects malaria infected people using
a stochastic model, particularly a simple SIRS model. A stochastic model
with the Markov property describes the dynamics of malaria and human
population in terms of stochastic equations. It is carried out by
estimating the malaria relapse rate and the reproduction number. In this
work, we used certain assumptions and presenting the SIRS model,
implemented on Python language with their transition diagrams. The
population dynamics are modelled by the SIRS model, which assumes only a
plasmodium vivax malaria in which pseudo recovered persons can recover
and return to the susceptible class or relapse and become infectious
again. The results suggest that SIRS model is effective model for
studying malaria transmission model with relapse and the reproduction
number, R_0 >1, implying an epidemic. Reproduction number
and infective population are increasing with respect to the relapse rate
and the study area is under the influence of malaria transmission; and
experiences the probability of an outbreak. Subject: Infectious Disease,
Global Health, Health Informatics and Statistical and Computational
Physics Key words: SIRS model, relapse rate, stochastic model, basic
reproduction number, Markov chain, epidemic.
A longitudinal study of unilateral Ménière’s disease and clinical evolutionary models Ménière’s based on the vertigo episodes.
Authors: Pérez-Carbonell Tomàs , Orts-Alborch Miguel , Pérez-Guillen Vanesa , Tenías-Burillo José María , Pla-Gil Ignacio , Algarra Jaime Marco , Pérez-Garrigues Herminio
Published: January 2024

INTRODUCTION: The variability in symptomatic evolution of vertiginous
crisis in Ménière’s disease (MD) is just one more fact that indicates
the great heterogeneity attributed to MD. Recently, these variations and
differences between patients are being defined by different subtypes of
MD. OBJECTIVES: We have defined subtypes of MD based on the evolution of
vertigo crisis in the first 10 years of the disease, in addition to
defining the natural history of Unilateral MD (UMD) in our environment.
DESIGN: A longitudinal descriptive study of patients with UMD was
carried out. In a subgroup of patients followed from the onset of the
disease, three subtypes or models of UMD were defined according to the
individual review and our experience according to the vertiginous crisis
suffered the first 10 years of the disease. In these models a
differential behavior has been studied attending to different variables
analyzed. RESULTS: Data were collected from 327 patients with UMD, of
which 87 were followed from the onset of the disease. In this subgroup,
patients were grouped in 3 models. Model No. 3 was associated with a
worse auditory prognosis, a greater number of Tumarkin crisis, the need
for surgery, and a more frequent mononymptomatic debut. Model No. 1
presented a lower hearing loss compared to the rest of the models.
CONCLUSION: Several studies tried to define subtypes of MD. In our study
we have defined 3 models of behavior in UMD based on the number of
crisis suffered, which present a differential behavior according to
different aspects.
Kappa opioids inhibit the GABA/glycine terminals of rostral ventromedial medulla projections in the superficial dorsal horn of the spinal cord
Authors: Aubrey Karin , Otsu Yo
Published: January 2024

Background and Purpose: Descending projections from neurons in the
rostral ventromedial medulla (RVM) make synapses within the superficial
dorsal horn of the spinal cord that are involved in acute nociception
and the development of chronic pain and itch. In addition, this
projection plays an important role in mediating the analgesic effects of
opioids. However, our knowledge about the spinal synaptic targets of RVM
projections and their modulation by opioids is lacking. Experimental
Approach: We used ex vivo optogenetic stimulation of RVM descending
fibres and whole-cell patch-clamp recordings from superficial dorsal
horn (SDH) neurons to identify the target neurons and to investigate
their descending synaptic inputs. Key Results: We demonstrate that SDH
neurons are targeted by descending GABA/glycine inhibitory inputs from
the RVM, although glycinergic inputs predominate. These SDH neurons had
diverse morphological and electrical properties. This inhibitory synapse
was presynaptically suppressed by the kappa opioid receptor agonist
U69593. By contrast, the mu-opioid receptor agonist DAMGO inhibited only
a subset of RVM-SDH synapses, acting both pre- and postsynaptically,
while the delta-opioid receptor agonist deltorphin II had little effect.
Conclusion and Implications: Developing reliable and effective
alternatives to opioid analgesics requires a detailed, mechanistic
understanding of how opioids interact with nociceptive circuits. This
study selectively and systematically characterises the synaptic
connections between RVM projection neurons and their SDH targets to
advance our knowledge of how this descending projection is organised and
modulated. In addition, it improves our understanding of how opioids
alter spinal pathways involved in the sensations of pain and itch.
Awareness and Knowledge of Pharmacists Toward Biosimilar Medicines
Authors: Oqal Muna , Hijazi Bushra , Alqudah Abdelrahim , Al-Smadi Ahmad , Almomani Basima A , Alnajjar Roaa , Gonaim Majd Abo , Irshaid Mohammad , Husam Aroob
Published: January 2024

ABSTRACT Aims Pharmacists in all clinical settings are recognized drug
experts and integral educators of biosimilar medicines. Therefore, the
objective of this study was to assess pharmacists’ knowledge, predictors
of knowledge and views toward biosimilar medicines in Jordan. Methods A
cross-sectional questionnaire was conducted in Jordan using an
internet-based self-administrated questionnaire via Google Forms. A
descriptive statistical analysis was performed to summarize the data for
the total sample as counts (percentage). Results A total of 502
pharmacists answered the survey. 52.6% were knowledgeable about
biosimilar medicines and the mean number of correct answers was 6.47 ±
1.62 (range 2–10). Multivariate analysis identified that respondents
who had heard about biosimilars before (OR = 1.942, 95% CI =
1.231-3.063, p <0.05) were more likely to be knowledgeable.
Respondents who had not taken course or post-graduating training course
about biosimilars were less likely to be knowledgeable (OR = 0.548, 95%
CI =0.357-0.839, p < 0.05). A positive response was noted in
pharmacist’s view regarding the implementation of biosimilar medicines
in healthcare setting, biosimilar medicine prescription related to
decreased costs, self-study about biosimilar medicine, and incorporating
biosimilar education program at the pharmacy school curriculum
universities level. Conclusions Pharmacists’ views and knowledge vary
regarding the particularities and key issues on biosimilar medicines in
Jordan. There is a need to improve communication between physicians and
pharmacists and pledge educational initiatives to ensure safe and
optimal use of biosimilar medicines. Incorporating biosimilar course in
pharmacy school curriculum could improve their acceptance for future
pharmacy jobs.
Validity and reliability of Turkish version of quality-of-life questionnaire in adult patients with common variable immune deficiency
Authors: Eyice Deniz , Demir Semra , İşsever Halim , Yeğit Osman Ozan , Can Ali , Tüzer Özdemir Can , Karadağ Pelin , Öztop Nida , Beyaz Şengül , Çolakoğlu Bahauddin , Büyüköztürk Suna , Pulvirenti Federica , Quinti Isabella , Gelincik Aslı
Published: January 2024

Background and Aims Common variable immunodeficiency (CVID) can affect
quality of life (QoL) which can be better assessed with validated
scales. Our goal was to validate the Turkish version of the Italian
CVID-QoL questionnaire. Methods International recommendations for
cultural adaptation and translation process of original scale was
followed. CVID patients completed Turkish CVID-QoL questionnaire between
October 2019 and January 2020. The Short Form Health Survey (SF-36) was
used as a comparative questionnaire. Reliability, reproducibility,
factor analysis, content validity, convergent validity and discriminant
validity were analysed. Results 50 CVID patients were included in the
study. 64 % of patients (n=32), the mean age of the patients was 36.68
± 13.2 years, the median duration of disease was 52.5 months. The
instrument had good internal consistency in 50 patients [Cronbach’s
alpha: 0.92, emotional functioning (EF): 0.91, relational functioning
(RF): 0.77]. It also revealed high reproducibility in 26 patients QoL
global, intraclass correlation coefficient (ICC)= 0.80 (95 % CI 0.56 -
0.91); EF, ICC = 0.78 (95 % CI 0.51- 0.90); RF, ICC = 0.82 (95 % CI
0.59-0.92); Gastrointestinal and skin symptoms (GSS), ICC = 0.89 (95 %
CI 0.76-0.95); (p <0.001, p <0.001, p
<0.001, p <0.001). QoL global, EF and RF scores
showed good convergent validity with similar subscales of SF-36. The
number of infections within last 3 months had a significant impact on
QoL global, EF and RF (p=0.038, p=0.045, p=0.028). Conclusions The
Turkish version of CVID QoL scale has appropriate validity and
reliability among Turkish patients with CVID.
On a Converse of Generalized ‘Useful’ Jensen’s Inequality with Data Illustration
Authors: DWIVEDI PANKAJ , Sharma Dilip
Published: January 2024

In the present communication, we give the converse of generalized
‘useful’ Jensen inequality and show that some recently reported
inequalities are simple consequences of those results that have been
established for a long time. We also include a new improvement of the
proposed inequality of Jensen as well as changes to some associated
outcomes, where generalized ‘useful’ converse of the Inequality of
Jensen is presented and implementations related to it are given in the
theory of information. Finally, it is shown with the help of numerical
data that inequalities holds well both for convex and concave functions.
Earlier maturation leads to increased ecological resilience of population
Authors: Zhang Fan
Published: January 2024

Understanding the effects of changing demographic characteristics on
population resilience is one of the fundamental questions in ecology.
Earlier maturation is a widely observed phenomenon among populations,
especially in fish populations under exploitation. However, the effects
of earlier maturation on ecological resilience of population have not
been explicitly studied. A classical age structured population dynamics
model (configured by empirical data of a population of American plaice
Hippoglossoides platessoides) is used to demonstrate that earlier
maturation increases both engineering and ecological resilience.
Accordingly, changing to earlier maturation could prevent upcoming
population regime shift, and management interventions to reduce
disturbance after detecting earlier maturation helps to revert
population collapse. This study demonstrates the potential of earlier
maturation to increase ecological resilience and prevent population
collapse, as well as acting as an early warning signal for management to
revert upcoming population regime shift.
Symbiotic microbiome Staphylococcus epidermidis restricts IL-33 production in allergic nasal epithelium by limiting cellular necroptosis
Authors: Kim Hyun Jik , Jeon Yung Jin , Cha Hyunkyung , Park Jin-A , Kim Su Geun
Published: January 2024

Remarkable progress has recently been achieved to identify the
biological function and potential value of interleukin (IL)-33 as a
novel therapeutic target of allergic rhinitis (AR) at the nasal
epithelium level. The nasal mucosa is constantly
exposed to inhaled allergens, and insights into the microbiota of human
nasal mucosa can provide fundamental information on factors contributing
to related allergic inflammation. However, a
mechanistic consideration of immunomodulatory properties of the nasal
microbiome to inhaled allergens has not been comprehensively performed
in AR. The purpose of this study was to show the distinctive role of the
nasal microbiome S. epidermidis, a major symbiont in healthy
nasal mucus, and the potential impact on reduction of T helper (Th)2
inflammation through decreased cellular necroptosis and subsequent IL-33
release in nasal epithelium.
Genomic variation in the black-throated green warbler (Setophaga virens) suggests divergence in a disjunct Atlantic Coastal Plain population (S. v. waynei)
Authors: Carpenter John , Worm Alexander , Boves Than , Wood Andrew , Poston Joseph , Toews David
Published: January 2024

New World wood warblers (family: Parulidae) can exhibit strong
phenotypic differences among species, particularly in song and plumage.
However, within-species variation in these warblers—often designated
as subspecies—is much more subtle and has led to significant debate
over the origin, maintenance, and conservation status of populations
that differ. A species that exhibits controversial subspecific status is
the black-throated green warbler (Setophaga virens), a
Neotropical-Nearctic migrant that breeds throughout eastern and boreal
North America with several isolated populations at the margins of its
range. In particular, uncertainty has lingered over the status of S. v.
waynei, a disjunct population along the southeast Atlantic Coastal Plain
of the United States that differs morphologically and ecologically from
the nominate subspecies. Despite its unique circumstances, the
subspecific status of S. v. waynei remains questionable in the absence
of any population-wide genomic analyses. Here, we employ whole-genome
resequencing to estimate the genetic distinctiveness among samples
collected across the entirety of S. virens breeding range, including
from putative S. v. waynei. Despite detecting low global differentiation
(FST = 0.027) across the entire species, we observed discrete genetic
clustering among S. v. waynei. Principal components analysis of
genome-wide differences shows the main axis of variation separates S. v.
waynei from all other S. v. virens samples. We also found that S. v.
waynei is most similar to another isolated population from the Piedmont
of North Carolina and detected evidence of a historical north-to-south
geographic dispersal among the entire complex. Combined with previously
documented ecological and morphological distinctness, our results
support that S. v. waynei be considered a distinct and recognized
subspecies worthy of targeted conservation efforts.
The psychological consequences of the COVID-19 pandemic in adults treated for childhood cancer
Authors: Janah Asmaa , Haddy Nadia , Demoor-Goldschmidt Charlotte , Bougas Nicolas , Clavel Jacqueline , Poulalhon Claire , LACOUR Brigitte , Souchard Vincent , Jackson Angela , Casagranda Leonie , Berger Claire , Allodji Rodrigue , El-Fayech Chiraz , Fresneau Brice , DEVATHAIRE Florent , Dumas Agnès
Published: January 2024

Objectives. Compared with the general population, childhood cancer
survivors (CCS) could be at greater risk of psychological distress
following the emergence of the COVID-19 pandemic. This cross-sectional
study assessed the psychological consequences of COVID-19 on the mental
health of CCS. Methods. In December 2020, we interviewed through an
online self-report questionnaire 580 5-year CCS participating in the
French Childhood Cancer Survivor Study (FCCSS) cohort. We first compared
the mental health score of CCS with that observed in the French general
population of the same age and gender. Subsequently, combining clinical
and patient-reported outcomes, we studied predictors of the mental
health score of CCS. Results. External comparisons revealed that the
mental health score of CCS was similar to that observed in the general
population. Among CCS, almost 42% stated that their psychological state
had been worse during the lockdown. Predictors of poorer mental health
included, among others, female gender, reporting a change of his/her
occupational situation, having a relative who had been hospitalized or
had died following COVID-19, and a greater perceived infection risk.
Conclusion. Given the pre-existing vulnerability of some CCS to mental
distress, the additional psychological consequences of COVID-19 in
vulnerable survivors should receive attention from health care
providers.
Chronic myeloid leukemia with CALR mutation: a case report
Authors: Xiaomin Gui , Ruibing Huang , Dexiang Ji , Wenhua Zhou
Published: January 2024

Cases with coexistence of myeloproliferative neoplasms related gene
mutations and BCR-ABL are rare. Herein, A 61-year-old female was
identified as CML with BCR-ABL gene fusion and CALR exon 9 mutation,
which is eventually diagnosed Chronic myeloid leukemia with CALR
mutation.
Generalized Chemical Block Systems on Chern-Simons φ∘ D∘ r2∘ S∘ r1 Topologies for the generation of the Roccustyrna Holomorphic Ligand.
Authors: Grigoriadis Ioannis
Published: January 2024

SARS coronavirus 2 (SARS - CoV - 2) in the viral spike (S) encoding a
SARS - COV - 2 SPIKE D614G mutation protein predominate over time in
locales revealing the dynamic aspects of its key viral processes where
it is found, implying that this change enhances viral transmission. In
this paper, we strongly combine topology geometric methods for
generalized formalisms of k - nearest neighbors as a Tipping–Ogilvie
and Machine Learning application within the quantum computing context
targeting the atomistic level of the protein apparatus of the SARS - COV
- 2 viral characteristics. In this effort, we propose computer - aided
rational drug design strategies efficient in computing docking usage,
and powerful enough to achieve very high accuracy levels for this in -
silico effort for the generation of AI - Quantum designed molecules of
GisitorviffirnaTM, Roccustyrna_gs1_TM, and Roccustyrna_fr1_TM
ligands targeting the COVID - 19 - SARS - COV - 2 SPIKE D614G mutation
by unifying Eigenvalue Statements into Shannon entropy quantities as
composed on Tipping–Ogilvie driven Machine Learning potentials for
nonzero Christoffel symbols for Schwarzschild (DFT) ℓneuron (ι) : == ==
φ∘D∘r2∘S∘r102 (1+∑) == == (A∧A’ (p)) • ⋱⋯⊗⋱⋯ •e− ρ (rr) −−¯σ − ¯σσ¯ǫ
−i_+02 (1− ) 2} () ) improver for Chern - Simons Topology Euclidean
Geometrics. I also arrived at a new Zmatter derived finite ‐ dimensional
state integral with a symplectic ω == == (i~)−1 (dx/x) ∧
(dy/y) model for computing the analytically continued “holomorphic
blocks” on an appropriate quantum Hilbert space H that compose physical
Chern ‐ Simons partition function to put pharmacophoric elements back
together.
5-year clinical results of 1073 patients with varicose veins treated using radiofrequency ablation, endovenous laser ablation and cyanoacrylate embolization
Authors: Atik Cem
Published: January 2024

Rationale and Aim: We should know the results of varicose vein treatment
methods before we can inform patients about them This study
retrospectively examined the clinical results of radiofrequency ablation
(RFA), endovenous laser ablation (EVLA), and cyanoacrylate embolization
(CAE) methods. Methods: This retrospective study presented the outcomes
of the procedures performed in the cardiovascular surgery clinic of a
private hospital in Osmaniye in the south of Turkey. No sampling was
performed. The study population consisted of 1256 patients who were
diagnosed with chronic venous insufficiency (CVI) and underwent
endovenous varicose veins treatment between February 2011 and April
2016. The sample consisted of 1073 patients who underwent CAE (n=431),
RFA (n=230), and EVLA (n=412). No patients underwent bilateral EVLA,
RFA, or CAE at the same session. Results: The majority of the
participants were women (79.59%). Most participants belonged to CEAP 2
and CEAP 3 classes (84.72%). The EVLA, RFA, and CAE groups had a mean
1-year occlusion rate of 97.57%, 98.26%, and 95.59%, respectively.
There was no significant difference in pre- and post-procedure VCSS
scores between the groups. All groups had the most complications in the
first month. There was a significant reduction in complications over
time in all groups. None of the patients developed complications in the
fifth year. Pain, paresthesia, ecchymosis, pigmentation, induration,
burn, DVT, and phlebitis were significantly more common in the EVLA
group. The complications were least common in the CAE group.
Conclusions: CAE, RFA, and EVLA have similar long-term results.
Therefore, CAE is recommended to patients with CVI who want to get rid
of varicose veins and improve their quality of life.
Severe aortic stenosis with alkaptonuria: a case report
Authors: Arnaz Ahmet , MAHMUDOV Vusal , dogan abdullah , ALTUN Dilek
Published: January 2024

Alkaptonuria, a rare metabolic disease, is caused by a genetic
deficiency of the homogentisic acid oxidase enzyme involved in
phenylalanine and tyrosine metabolism. Ochronotic arthropathy and
cardiovascular involvement, which manifests itself in 4-6 decades as a
result of homogentisic acid accumulation in cartilage and connective
tissue, are the most important causes of mortality and morbidity. We
present a 75-year-old case with a diagnosis of severe aortic stenosis
who was diagnosed with alkaptonuria after the operation. Severe
calcification and pigmentation were observed in the patient’s aortic
valve leaflets and at the ascending aortic wall
Juvenile myelomonocytic leukemia in a child: a case report of palliative chemotherapy and literature review applied to limited resources centers
Authors: Yolanda Natharina , Gunawan Stefanus , Mantik Max , Veerman Anjo JP
Published: January 2024

Juvenile myelomonocytic leukemia (JMML) is a rare hematopoietic
malignancy in children with incidence 1.2 per million children per year.
Hereby we present a case report and brief literature review of JMML in a
child, especially focused on applicability in low-middle income
countries. A 3.5 years-old male was referred to our tertiary center due
to pallor, enlarging abdomen and neck mass, recurrent fever and chronic
diarrhea. Initial laboratory workup showed Hb 6.4 g/dl, white blood cell
315.62 x 103/uL, and platelet 17 x 103/uL. Blood smears showed 10%
suspected blast, 17% myelocyte, 17% metamyelocytes, with
thrombocytopenic crisis. The HbF level was 5.8%. BCR-ABL gene was
tested negative. The patient was diagnosed as juvenile myelomonocytic
leukemia. Considering that HSCT was not able to be done in our center
and lack of financial possibilities to seek that treatment abroad,
family agreed to do palliative treatment. Patient was treated with
6-mercaptopurin and subcutaneous cytarabine. Four weeks after receiving
6-MP, white blood cell count decreased to 10,6 x 103/uL and spleen size
was half of the original size. Patient continued the chemotherapy until
week 15, chemotherapy was stopped, but 16 weeks after the diagnosis of
JMLL, he developed severe thrombocytopenia, endophthalmitis, sepsis and
passed away.
Nausea and vomiting caused by esophageal candidiasis in an elderly frail patient: A Case report.
Authors: Kiba Takayoshi , Kotoh Naoki , Namba Yoichiro , Nose Soichiro , Tsuboi Masahiro
Published: January 2024

Nausea and vomiting significantly affect quality of life. We report a
case of esophagus candidiasis incidentally discovered in an elderly
frail female, who underwent esophagogastroduodenoscopy for severe nausea
and vomiting symptoms. After the treatment for esophageal candidiasis,
immediately, she relieved the symptoms of nausea and vomiting, and
increased appetite gradually.
Two Severe Perioperative Hypersensitivity Reactions in a Single Patient - A Case Report of a Medication Error
Authors: Mikulic Iva , EXED) Robert Likic (NO NEW ASSIGNMENTS AS , Cegec Ivana , Turk Viktorija Erdeljić , Aumiler Matea Radacic , Ausperger Ksenija Makar , Šimić Iveta
Published: January 2024

Perioperative immediate hypersensitivity reactions are serious but rare
clinical problems that require further evaluation for possible drug
allergy. Hypersensitivity reactions and medication errors are types of
adverse drug reactions. Here we present a case of two perioperative
hypersensitivity reactions in a single patient due to hypersensitivity
to neuromuscular blocking agents, the second of which was a medication
error, and the possible circumstances that led to such outcomes.
Uniqueness result and iterative method for fourth order $p$-Laplacian integral boundary value problems with different nonlinear terms
Authors: Yang Youyuan , huang jianfeng , Yuan Liguo
Published: January 2024

In this paper, by using the contraction mapping principle, we establish
the existence and uniqueness of solutions for the fourth order
$p$-Laplacian beam equations
$(\Phi_{p}(u’‘(t)))’‘=f(t, u(t), u’(t), u’‘(t))$
with integral boundary conditions
$u’‘(0)=u’‘(1)=0,u(0)-\alpha u’(0)=
\int_{0}^{1}g_{1}(s)u(s)ds,
u(1)+\beta u’(1)=
\int_{0}^{1}g_{2}(s)u(s)ds$. The monotony of
iterations is also considered. As an extension, we obtain the uniqueness
and iterative solutions of the fourth order $p$-Laplacian integral
boundary value problems with fully nonlinear term
$(\Phi_{p}(u’‘(t)))’‘=f(t, u(t), u’(t), u’‘(t),
u”’(t))$. At last, some examples are presented to illustrate the main
results.
Using major components of biodiesel: Evaluating the applicability of different machine learning for predicting the CFPP
Authors: Wang wenchao , Qi Huini , Li Fashe , Wang Hua
Published: January 2024

Prediction of CFPP for biodiesel based on fatty acid methyl esters
composition is the focus of the presented research. A total of 90 fuel
samples were derived from the literature and an additional 10 fuel
samples were obtained through experimentation in order to provide an
initial data set for predictive model development and training. The
adaptability of RBFNN in predicting the CFPP of biodiesel is discussed,
and the prediction performance compared with MLR and BPNN. When using
MLR, BPNN and RBFNN for predicting CFPP of biodiesel, results
demonstrated a R2 of 0.9273, 0.9990 and 0.9999, respectively. By
subsequently calculating the performance evaluation index of the model,
the RBFNN model’s RMSE, NRMSE and SSE are the closest to 0 compared to
the other two techniques. Based on the outcome of this study, these
techniques can be effective tools for predicting CFPP of biodiesels,
with RBFNN showing the most promise.
What’s past is past, mostly: Brassicaceae host plants mask the feedback from the previous year’s soil history on bacterial communities, except when the Brassicaceae hosts experience drought
Authors: Blakney Andrew , Bainard Luke , St-Arnaud Marc , Hijri Mohamed
Published: January 2024

Previous soil history and the current plant hosts are two plant-soil
feedbacks that operate at different time-scales to influence the
structure soil bacterial communities. In this study, we used a MiSeq
metabarcoding strategy to describe the impact of five Brassicaceae host
plant species, and three different soil histories, on the structure of
their bacterial root and rhizosphere communities at full flower. We
found that the Brassicaceae host plants were consistently significant in
structuring the bacterial communities. Four host plants (Sinapis alba,
Brassica napus, B. juncea, B. carinata) formed nearly the same bacterial
communities, regardless of soil history. Camelina sativa host plants
structured phylogenetically distinct bacterial communities compared to
the other hosts, particularly in their roots. Soil history established
the previous year was only a significant factor for bacterial community
structure when the feedback of the Brassicaceae host plants was
weakened, potentially due to limited soil moisture during a dry year.
Understanding how plant-soil feedbacks operate at different time-scales
and are involved in how microbial communities are structured is a
pre-requisite for employing microbiome technologies in improving
agricultural systems.
The Chinese burden of atrial fibrillation Systematic review of atrial fibrillation studies in China
Authors: jianshu song , Gao Hongbo , Li Qi , Li Longfei , Wang Xue , Yu Xue , Wang Shaocong , Liu Xu
Published: January 2024

Background: Atrial fibrillation (AF) is one of the most common
heart rate disorders, but most relevant studies are mainly focused on
Europe and The United States, while information about AF in Chinese
population is scarce. The purpose of this study was to provide a
systematic review of the literature on atrial fibrillation in China. To
the best of our knowledge, this is the first systematic review for
China’s burden of AF. Methods: A systematic literature search
(Medline 2001-2021) identified studies reporting the prevalence or
incidence of ATRIAL fibrillation, risk factors for atrial fibrillation,
comorbidities of atrial fibrillation, and use of antithrombotic therapy
in China. This report focuses on descriptive analytical data.
Results: Studies reported a wide variation in the prevalence of
AF, with a range of community-based and hospital-based AF rates (from
0.49% to 8.8% and 4.4-35.7%). Aspirin and warfarin use were found to
be particularly low in community-based studies in China, and warfarin
and amiodarone use were higher in hospital-based studies than in other
countries. Stroke is the most common complication of atrial
fibrillation. Conclusions: We need higher quality studies to
understand the burden of AF in China and work to improve community
delivery and monitoring of antithrombotic therapy after AF. Given the
size of China’s population, the impact on healthcare resources could be
significant in the future.