bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comparative Evaluation of Desoximetasone Cream and Ointment Formulations Using Experiments and In Silico Modeling
Authors: Matharoo Namrata S. , Garimella Harsha T. , German Carrie , Przekwas Andrzej J. , Michniak-Kohn Bozena
Published: October 2023

The administration of therapeutic drugs through dermal routes, such as creams and ointments, has emerged as an increasingly popular alternative to traditional delivery methods, such as tablets and injections. In the context of drug development, it is crucial to identify the optimal doses and delivery routes that ensure successful outcomes. Physiologically based pharmacokinetic (PBPK) models have been proposed to simulate drug delivery and optimize drug formulations, but the calibration of these models is challenging due to the multitude of variables involved and limited experimental data. One significant research gap that this article addresses is the need for more efficient and accurate methods for calibrating PBPK models for dermal drug delivery. This manuscript presents a novel approach and an integrated dermal drug delivery model to address this gap that leverages virtual in vitro release (IVRT) and permeation (IVPT) testing data to optimize mechanistic models. The proposed approach was demonstrated through a study involving Desoximetasone cream and ointment formulations, where the release kinetics and permeation profiles of Desoximetasone were determined experimentally, and a computational model was created to simulate the results. The experimental studies showed that, even though the cumulative permeation of Desoximetasone at the end of the permeation study was comparable, there was a significant difference seen in the lag time in the permeation of Desoximetasone between the cream and ointment. Additionally, there was a significant difference seen in the amount of Desoximetasone permeated through human cadaver skin at early time points when the cream and ointment were compared. The computational model was optimized and validated, suggesting that this approach has the potential to bridge the existing research gap by improving the accuracy and efficiency of drug development processes. The model results show a good fit between the experimental data and model predictions. During the model optimization process, it became evident that there was variability in both the permeability and the partition coefficient within the stratum corneum. This variability had a significant and noteworthy influence on the overall performance of the model, especially when it came to its capacity to differentiate between cream and ointment formulations. Leveraging virtual models significantly aids the comprehension of drug release and permeation, mitigating the demanding data requirements. The use of virtual IVRT and IVPT data can accelerate the calibration of PBPK models, streamline the selection of the appropriate doses, and optimize drug delivery. Moreover, this novel approach could potentially reduce the time and resources involved in drug development, thus making it more cost-effective and efficient.
Flubendazole Enhances the Inhibitory Effect of Paclitaxel via HIF1α/PI3K/AKT Signaling Pathways in Breast Cancer
Authors: Zhou Yuxin , Liao Minru , Li Zixiang , Ye Jing , Wu Lifeng , Mou Yi , Fu Leilei , Zhen Yongqi
Published: October 2023

Paclitaxel, a natural anticancer drug, is widely recognized and extensively utilized in the treatment of breast cancer (BC). However, it may lead to certain side effects or drug resistance. Fortunately, combination therapy with another anti-tumor agent has been explored as an option to improve the efficacy of paclitaxel in the treatment of BC. Herein, we first evaluated the synergistic effects of paclitaxel and flubendazole through combination index (CI) calculations. Secondly, flubendazole was demonstrated to synergize paclitaxel-mediated BC cell killing in vitro and in vivo. Moreover, we discovered that flubendazole could reverse the drug resistance of paclitaxel-resistant BC cells. Mechanistically, flubendazole was demonstrated to enhance the inhibitory effect of paclitaxel via HIF1α/PI3K/AKT signaling pathways. Collectively, our findings demonstrate the effectiveness of flubendazole in combination with paclitaxel for treating BC, providing an insight into exploiting more novel combination therapies for BC in the future.
Photo- and Sono-Active Food Colorants Inactivating Bacteria
Authors: Hochma Efrat , Hovor Iryna , Nakonechny Faina , Nisnevitch Marina
Published: October 2023

Food colorants are commonly used as excipients in pharmaceutical and nutraceutical fields, but they have a wide range of other potential applications, for instance, as cytotoxic drugs or mediators of physical antimicrobial treatments. The photodynamic antibacterial activity of several edible food colorants is reported here, including E127, E129, E124, E122, E133, and E150a, alongside Rhein, a natural lipophilic antibacterial and anticancer compound found in medicinal plants. Minimal inhibitory concentration (MIC) values for S. aureus and E. coli showed that E127 and Rhein were effective against both bacteria, while other colorants exhibited low activity against E. coli. In some cases, dark pre-incubation of the colorants with Gram-positive S. aureus increased their photodynamic activity. Adding Rhein to E127 increased the photodynamic activity of the latter in a supportive mode. Optional sensing mechanism pathways of combined E127/Rhein action were suggested. The antibacterial activity of the studied colorants can be ranged as follows: E127/Rhein >> E127 >> E150a > E122 > E124 >> E129 ≈ E133. E127 was also found to exhibit photodynamic properties. Short ultrasonic treatment before illumination caused intensification of E127 photodynamic activity against E. coli when applied alone and especially in combination with Rhein. Food colorants exhibiting photo- and sonodynamic properties may have good potential in food preservation.
miRNA Expression Signatures Induced by Chicken Astrovirus Infection in Chickens
Authors: Sajewicz-Krukowska Joanna , Mirosław Paweł , Jastrzębski Jan P. , Domańska-Blicharz Katarzyna , Tarasiuk Karolina , Marzec-Kotarska Barbara
Published: October 2023

miRNAs represent ubiquitous regulators of gene expression and play an important and pivotal regulatory role in viral disease pathogenesis and virus–host interactions. Although previous studies have provided basic data for understanding the role of miRNAs in the molecular mechanisms of viral infection in birds, the role of miRNAs in the regulation of host responses to chicken astrovirus (CAstV) infection in chickens is not yet understood. In our study, we applied next-generation sequencing to profile miRNA expression in CAstV-infected chickens and to decipher miRNA-targeted specific signaling pathways engaged in potentially vital virus-infection biological processes. Among the 1354 detected miRNAs, we identified 58 mature miRNAs that were significantly differentially expressed in infected birds. Target prediction resulted in 4741 target genes. GO and KEGG pathway enrichment analyses showed that the target genes were mainly involved in the regulation of cellular processes and immune responses.
Comprehensive Analysis of Factors Associated with New Episode of Postoperative Atrial Fibrillation after Coronary Artery Bypass Graft Surgery
Authors: Rubanenko Olesya , Rubanenko Anatoly , Davydkin Igor
Published: October 2023

The aim of the study was to perform a comprehensive fundamental analysis of the factors of inflammation, oxidative stress, fibrosis, myocardial dysfunction, ischemia and omega-3 index associated with postoperative atrial fibrillation (POAF) after coronary artery bypass graft (CABG) surgery in patients with coronary artery disease. The study involved 158 patients who were admitted to the hospital to undergo CABG surgery. Patients were divided into two groups: group 1 comprised 111 patients without POAF (82% males, median age—62.0 (56.0; 66.0) years), and group 2 comprised 47 patients with POAF (84.4% males, median age—65.0 (61.0; 70.0) years). POAF occurred 5.2 (2.0; 7.0) days after CABG. In all the patients, we evaluated laboratory tests before and 3–4 days after CABG. All the patients also underwent echocardiography. According to results of multifactorial regression analysis, the odds ratio of POAF development for left atrial diameter >41 mm was 4.3 (95% confidence interval (CI) 2.0–9.7, p < 0.001), interleukin (IL)-6 postoperative levels >22.07 pg/mL—3.0 (95% CI 1.4–8.2, p = 0.006), IL-8 postoperative levels >9.67 pg/mL—2.3 (95% CI 1.2–7.3, p = 0.006), superoxide dismutase postoperative levels in plasma >1100.5 U/g—3.2 (95% CI 1.4–9.2, p = 0.03), glutathione postoperative levels ≤0.194 micromole/g of hemoglobin—1.9 (95% CI 1.2–6.3, p < 0.001), glutathione peroxidase postoperative levels ≤17.36 millimole/g of hemoglobin—2.2 (95% CI 1.1–8.2, p < 0.001), glutathione reductase postoperative levels ≤2.99 millimole/g of hemoglobin—2.3 (95% CI, 1.1–5.7, p < 0.001), malondialdehyde postoperative levels >1.25 micromole/g of hemoglobin—2.0 (95% CI, 1.2–7.9, p < 0.001), NO postoperative levels in plasma >36.4 micromole/L—1.5 (95% CI, 1.1–5.9, p < 0.001) and omega-3 index ≤1.59%—2.6 (95% CI 1.5–9.1, p < 0.001). Our study showed that increased left atrial diameter, high postoperative levels of inflammatory factors, oxidative stress, fibrosis indicators and omega-3 index were associated with POAF in patients who underwent CABG.
Stability Modification of Dye-sensitized Solar Cells by Ruthenium Dyes Embedded on Eggshell Membranes
Authors: Tanifuji Naoki , Shimizu Takeshi , Shimizu Akihiro , Shimizu Kaho , Abe Kizuna , Tanaka Miki , Wang Heng , Yoshikawa Hirofumi
Published: October 2023

Dye-sensitized solar cells (DSSCs) have been one of the most promising technologies to convert sunlight into electricity repeatedly based on the mechanism that dyes inject/accept electron into the metal oxides/from redox mediator. Specifically, N719 ([RuL2(NCS)2], L: 4,4′-dicarboxy-2,2′-bipyridine), immobilized on TiO2 through the interaction between its ligands (-COO− and -NCS) and the oxygen on the TiO2 surface, has been used as a conventional DSSC dye with high voltage. Nevertheless, -NCS ligands have been removed from Ru2+ in N719 due to UV irradiation and exchanged with H2O or OH− in electrolyte, resulting in voltage drop. In this work, we developed the first DSSC using the N719-adsorbed Eggshell (ESM)-TiO2 composite to maintain the immobilization of N719 on TiO2 through electrostatic interaction between the protein of ESM and N719. The DSSC using the composite maintained the voltage even after 12 h light irradiation, although the voltage of DSSC without ESM dropped drastically. It means that the ESM contributed to stable photovoltaic performances of DSSCs through the protection of NCS ligands of N719.
Influence of Pre-Incubation of Inoculum with Biochar on Anaerobic Digestion Performance
Authors: Valentin Marvin T. , Świechowski Kacper , Białowiec Andrzej
Published: October 2023

The application of biochar as an additive to enhance the anaerobic digestion (AD) of biomass has been extensively studied from various perspectives. This study reported, for the first time, the influence of biochar incubation in the inoculum on the anaerobic fermentation of glucose in a batch-type reactor over 20 days. Three groups of inoculum with the same characteristics were pre-mixed once with biochar for different durations: 21 days (D21), 10 days (D10), and 0 days (D0). The BC was mixed in the inoculum at a concentration of 8.0 g/L. The proportion of the inoculum and substrate was adjusted to an inoculum-to-substrate ratio of 2.0 based on the volatile solids. The results of the experiment revealed that D21 had the highest cumulative methane yield, of 348.98 mL, compared to 322.66, 290.05, and 25.15 mL obtained from D10, D0, and the control, respectively. Three models—modified Gompertz, first-order, and Autoregressive Integrated Moving Average (ARIMA)—were used to interpret the biomethane production. All models showed promising fitting of the cumulative biomethane production, as indicated by high R2 and low RMSE values. Among these models, the ARIMA model exhibited the closest fit to the actual data. The biomethane production rate, derived from the modified Gompertz Model, increased as the incubation period increased, with D21 yielding the highest rate of 31.13 mL/gVS. This study suggests that the application of biochar in the anaerobic fermentation of glucose, particularly considering the short incubation period, holds significant potential for improving the overall performance of anaerobic digestion.
Secure and Robust Demand Response Using Stackelberg Game Model and Energy Blockchain
Authors: Samadi Mikhak , Ruj Sushmita , Schriemer Henry , Erol-Kantarci Melike
Published: October 2023

Demand response (DR) has been studied widely in the smart grid literature, however, there is still a significant gap in approaches that address security, privacy, and robustness of settlement processes simultaneously. The need for security and robustness emerges as a vital property, as Internet of Things (IoT) devices become part of the smart grid; in the form of smart meters, home energy management systems (HEMSs), intelligent transformers, and so on. In this paper, we use energy blockchain to secure energy transactions among customers and the utility. In addition, we formulate a mixed-strategy stochastic game model to address uncertainties in DR contributions of agents and achieve optimal demand response decisions. This model utilizes the processing hardware of customers for block mining, stores customer DR agreements as distributed ledgers, and offers a smart contract and consensus algorithm for energy transaction validation. We use a real dataset of residential demand profiles and photovoltaic (PV) generation to validate the performance of the proposed scheme. The results show the impact of electric vehicle (EV) discharging and customer demand reduction on increasing the probability of successful block mining and improving customer profits. Moreover, the results demonstrate the security and robustness of our consensus algorithm for detecting malicious activities.
A Novel Electrophoretic Technique to Improve Metasurface Sensing of Low Concentration Particles in Solution
Authors: Kurland Zachary A. , Goyette Thomas
Published: October 2023

A novel electrophoretic technique to improve metasurface sensing capabilities of charged particles in solution is presented. The proposed technique may improve the ability of metasurfaces to sense charged particles in solution in a manner not possible using the current standard of particle deposition (which allows particles to sediment randomly on a metasurface under evaporation) by inducing an external, nonuniform electric field through the metasurface apertures. Such a technique may be useful in various sensing applications, such as in biological, polymer, or environmental sciences, where low concentration particles in solution are of interest. The electrophoretic technique was simulated and experimentally tested using latex nanoparticles in solution. The results suggest that, using this technique, one may theoretically increase the particle density within the metasurface regions of greatest sensitivity by nearly 1900% in comparison to random sedimentation due to evaporation. Such an increase in particle density within the regions of greatest sensitivity may facilitate more precise material property measurements and enhance identification and detection capabilities of metasurfaces to particles in solution which constitute only a few hundred parts per million by mass. It was experimentally determined that the electrophoretic technique enhanced metasurface sensing capabilities of 333 parts per million by mass latex nanoparticle solutions by nearly 1700%.
ExistenceMap-PointPillars: A Multifusion Network for Robust 3D Object Detection with Object Existence Probability Map
Authors: Hariya Keigo , Inoshita Hiroki , Yanase Ryo , Yoneda Keisuke , Suganuma Naoki
Published: October 2023

Recognition of surrounding objects is crucial for ensuring the safety of automated driving systems. In the realm of 3D object recognition through deep learning, several methods incorporate the fusion of Light Detection and Ranging (LiDAR) and camera data. The effectiveness of the LiDAR–camera fusion approach is widely acknowledged due to its ability to provide a richer source of information for object detection compared to methods that rely solely on individual sensors. Within the framework of the LiDAR–camera multistage fusion method, challenges arise in maintaining stable object recognition, especially under adverse conditions where object detection in camera images becomes challenging, such as during night-time or in rainy weather. In this research paper, we introduce "ExistenceMap-PointPillars", a novel and effective approach for 3D object detection that leverages information from multiple sensors. This approach involves a straightforward modification of the LiDAR-based 3D object detection network. The core concept of ExistenceMap-PointPillars revolves around the integration of pseudo 2D maps, which depict the estimated object existence regions derived from the fused sensor data in a probabilistic manner. These maps are then incorporated into a pseudo image generated from a 3D point cloud. Our experimental results, based on our proprietary dataset, demonstrate the substantial improvements achieved by ExistenceMap-PointPillars. Specifically, it enhances the mean Average Precision (mAP) by a noteworthy +4.19% compared to the conventional PointPillars method. Additionally, we conducted an evaluation of the network’s response using Grad-CAM in conjunction with ExistenceMap-PointPillars, which exhibited a heightened focus on the existence regions of objects within the pseudo 2D map. This focus resulted in a reduction in the number of false positives. In summary, our research presents ExistenceMap-PointPillars as a valuable advancement in the field of 3D object detection, offering improved performance and robustness, especially in challenging environmental conditions.
The Detection System for a Danger State of a Collision between Construction Equipment and Workers Using Fixed CCTV on Construction Sites
Authors: Seong Jaehwan , Kim Hyung-soo , Jung Hyung-Jo
Published: October 2023

According to data from the Ministry of Employment and Labor in Korea, a significant portion of fatal accidents on construction sites occur due to collisions between construction workers and equipment, with many of these collisions being attributed to worker negligence. This study introduces a method for accurately localizing construction equipment and workers on-site, delineating areas prone to collisions as ‘a danger area of a collision’, and defining collision risk states. Utilizing advanced deep learning models which specialize in object detection, video footage obtained from strategically placed closed-circuit television (CCTV) cameras across the construction site is analyzed. The positions of each detected object are determined using transformation or homography matrices representing the conversion relationship between a sufficiently flat reference plane and image coordinates. Additionally, ‘a danger area of a collision’ is proposed for evaluating equipment collision risk based on the moving equipment’s speed, and the validity of this area is verified. Through this, the paper presents a system designed to preemptively identify potential collision risks, particularly when workers are located within the ‘danger area of a collision’, thereby mitigating accident risks on construction sites.
Designing and Developing a Vision-Based System to Investigate the Emotional Effects of News on Short Sleep at Noon: An Experimental Case Study
Authors: Moshayedi Ata Jahangir , Uddin Nafiz Md Imtiaz , Khan Amir Sohail , Zhu Jianxiong , Emadi Andani Mehran
Published: October 2023

Background: Sleep is a critical factor in maintaining good health, and its impact on various diseases has been recognized by scientists. Understanding sleep patterns and quality is crucial for investigating sleep-related disorders and their potential links to health conditions. The development of non-intrusive and contactless methods for analyzing sleep data is essential for accurate diagnosis and treatment. Methods: A novel system called the sleep visual analyzer (VSleep) was designed to analyze sleep movements and generate reports based on changes in body position angles. The system utilized camera data without requiring any physical contact with the body. A Python graphical user interface (GUI) section was developed to analyze body movements during sleep and present the data in an Excel format. To evaluate the effectiveness of the VSleep system, a case study was conducted. The participants’ movements during daytime naps were recorded. The study also examined the impact of different types of news (positive, neutral, and negative) on sleep patterns. Results: The system successfully detected and recorded various angles formed by participants’ bodies, providing detailed information about their sleep patterns. The results revealed distinct effects based on the news category, highlighting the potential impact of external factors on sleep quality and behaviors. Conclusions: The sleep visual analyzer (VSleep) demonstrated its efficacy in analyzing sleep-related data without the need for accessories. The VSleep system holds great potential for diagnosing and investigating sleep-related disorders. The proposed system is affordable, easy to use, portable, and a mobile application can be developed to perform the experiment and prepare the results.
Nanotechnology and E-Sensing for Food Chain Quality and Safety
Authors: Poeta Elisabetta , Liboà Aris , Mistrali Simone , Núñez-Carmona Estefanía , Sberveglieri Veronica
Published: October 2023

Nowadays, it is well known that sensors have an enormous impact on our life, using streams of data to make life-changing decisions. Every single aspect of our day is monitored via thousands of sensors, and the benefits we can obtain are enormous. With the increasing demand for food quality, food safety has become one of the main focuses of our society. However, fresh foods are subject to spoilage due to the action of microorganisms, enzymes, and oxidation during storage. Nanotechnology can be applied in the food industry to support packaged products and extend their shelf life. Chemical composition and sensory attributes are quality markers which require innovative assessment methods, as existing ones are rather difficult to implement, labour-intensive, and expensive. E-sensing devices, such as vision systems, electronic noses, and electronic tongues, overcome many of these drawbacks. Nanotechnology holds great promise to provide benefits not just within food products but also around food products. In fact, nanotechnology introduces new chances for innovation in the food industry at immense speed. This review describes the food application fields of nanotechnologies; in particular, metal oxide sensors (MOS) will be presented.
Cultivating Sustainable Supply Chain Practises in Electric Vehicle Manufacturing: A MCDM Approach to Assessing GSCM Performance
Authors: Althaqafi Torky
Published: October 2023

Sustainability emphasises the crucial need to incorporate environmentally conscious practises across the entire supply chain management process in the modern age. A great emphasis is placed on minimising environmental consequences, eliminating waste, conserving energy, and sourcing materials responsibly in the production, distribution, and disposal of electric vehicles. Electric vehicle manufacturers must prioritise sustainability to ensure that their products contribute significantly to a brighter future while also meeting the ethical and environmental demands of consumers as well as regulatory bodies. Green supply chain management (GSCM) incorporates environmentally friendly practises to reduce environmental effects. This study incorporates fuzzy TOPSIS for analysing and rating GSCM practises, assisting decision-makers in prioritising sustainability in the supply chains of electric vehicle manufacturers. We develop a multi-criteria decision-making framework to evaluate GSCM criteria while accounting for inherent uncertainty. Fuzzy TOPSIS handles linguistic problems as well as ambiguity while providing a precise GSCM representation. Real-world case studies from various sectors demonstrate the applicability and benefits of our approach to finding improvement areas and expediting GSCM assessments. This research presents a systematic, quantitative way for evaluating GSCM practises, allowing supply chain alignment with sustainability goals. This promotes environmentally sustainable practises and increases the sustainability of supply chains for electric car manufacturing.
The gene of education in the social nature of journalism
Authors:   Department of Journalism, Moscow University for the Humanities, Kirichek Petr Nikolaevich
Published: October 2023

The article examines an essential aspect of media education and journalistic practice related to the role and importance of the media in the process of public education. The features of the public transfer of moral attitudes from producers of mass information (journalists) to its consumers (citizens) are revealed.
Andrey Platonov on the education of patriotism and the mission of “engineers of human souls”
Authors:   Department of Humanitarian Disciplines, Russian State Academy of Arts, Moscow, Kirillina Olga Mikhailovna
Published: October 2023

The article analyzes A. Platonov’s ideas about the organic, natural education of patriotism and the transformation of a person’s negative energy into positive energy, and shows that it was in the most difficult moments for the country that the writer felt most in demand and was inspired. According to Platonov, the poet should not take a position of condescension towards the people, since, first of all, the poet is the conductor of their will and thoughts. The article shows the logic of A. Platonov’s reasoning and shows the source of his inspiration and patriotism
History of the Great Silk Road: modern stage
Authors:   Kazakh Ablai Khan University of International Relations and World Languages (Republic of Kazakhstan), Moscow University for the Humanities, Doszhanova Akmaral Ivanovna
Published: October 2023

This article discusses the issues and problems of interpreting the history of the Great Silk Road at the present stage. The general geopolitical tension between East and West became overt, which directly affected the development of the ancient transcontinental corridor. The functioning of the Great Silk Road is under threat, since the natural transport corridor today cannot operate fully, but its socio-cultural and humanitarian component does not cease to serve as an exchange of ideas and opinions. The materials in the article may be useful as part of preparation in the areas of International Relations and Foreign Regional Studies.
Polycythemia, emperipolesis and extramedullary haematopoiesis caused by acute shock: the first record in the Northern white-breasted hedgehog Erinaceus roumanicus Barrett-Hamilton, 1900
Authors: Suljevic Damir , Focak Muhamed , Lukic Bilela Lada
Published: October 2023

An adult female hedgehog Erinaceus roumanicus, was found in a city traffic zone, exhibiting severe injuries consistent with a vehicular collision. Rapid diagnostics, including X-ray imaging, were performed at the veterinarian clinic to rescue the animal. Due to multiple traumatic injuries and poor prognosis, the animal was anesthetized for blood sampling and then euthanized. Polycythaemia, platelet aggregation, rare megakaryoblasts, neutrophilia, lymphocytosis, and a high red blood cell (RBC) and white blood cell (WBC) count were found in peripheral blood. Eosinophilia and the physiological phenomenon of emperipolesis were detected in the femur bone marrow, while the liver biopsy confirmed the extramedullary haematopoiesis (EMH). Acute hypovolemic shock results in rapid changes in hematological and biochemical parameters, endangering the patient's life. Treatment of hypovolemic shock and intensive care of small and exotic animals is further complicated by their small size, physiological diversity, lack of research and clinical data on their response to therapy. Given the increased vulnerability of the small mammal fauna as a result of expanding urbanization, this case study aims to facilitate the recognition of this life-threatening condition, the possible physiological response in hedgehogs and the adequate care of injured animals. Raising awareness of the fragmentation and decline of their populations in the habitats they share with humans can contribute to finding solutions to mitigate their road mortality, and improve their well-being and conservation.
Misono, premiers cosmétiques japonais sans plomb : analyse d’une création à succès
Authors: Bonte Louis , Bonté Frédéric
Published: October 2023

Les produits cosmétiques de la société japonaise Kocho-en sont les premiers cosmétiques blanchissants japonais sans plomb agrées par la famille impériale. Le créateur de ces produits est le chimiste Nakahiko Hasebe qui a étudié la chimie en France. Après des recherches, il propose en 1900 à la cour impériale une poudre cosmétique à base d’oxyde de zinc. Il la commercialise quatre ans plus tard sous le nom de Misono Oshiroi. Cet article décrit le succès des premières années de la société au travers d’un rare livret publicitaire des produits cosmétiques Misono, certifiés inoffensifs par deux grands pharmaciens japonais, Y Tahara et J Shimoyama. L’univers concurrentiel et l’importation de produits cosmétiques occidentaux sont également évoqués.
ВПЛИВ МОДЕЛЮВАННЯ ЕКСПЕРИМЕНТАЛЬНОЇ ДЕМЕНЦІЇ НА ПОВЕДІНКОВІ РЕАКЦІЇ ТА ПОКАЗНИКИ АТРОФІЇ ЩЕЛЕП У ЩУРІВ
Authors: Бабеня Г.О. , Гаращук І.В.
Published: October 2023

Мета дослідження. Оцінка впливу алюмінієвої інтоксикації на когнітивні властивості щурів та показники атрофічних процесів у тканинах пародонту експериментальних тварин. Матеріали та методи дослідження. Експериментальні дослідження проведені згідно вимог Закону України «Про захист тварин від жорстокого поводження» та Порядку проведення науковими установами дослідів, експериментів на тваринах з дотриманням біоетичних норм. Експеримент було проведено на 16 самцях білих щурів, що були розділені на 2 групи: 1 група – інтактні тварини (n = 8); 2 група – введення водного розчину AlCl3 (моделювання деменції) (n = 8). Щурів утримували в стандартних умовах віварію при сталій температурі та вологості повітря. Результати досліджень та їх обговорення. Маса щурів в групах складала у середньому 258,5 г на початку експерименту та зростала під кінець експерименту. Було вивчено особливості поведінкових реакцій щурів усіх груп у лабіринті Барнса із застосуванням сторонніх подразників. Досліджено ступінь резорбтивних процесів у тканинах пародонта щурів. Було також досліджено вплив алюмінієвої інтоксикації на показники атрофії альвеолярного відростка експериментальних щурів. Висновки. Показано, що тривала інтоксикація хлоридом алюмінію у щурів призвела до підвищення кількості помилок у 1,5 рази, часу проходження лабіринту у 2,2 рази порівняно з контролем. Спостерігали зміну стратегії пошуку «рятівної» лунки від «послідовної» до «випадкової» протягом періоду досліджень, що підтверджує відтворення у щурів експериментальної деменції. Встановлено достовірне збільшення ступеня атрофії альвеолярного відростка щелеп щурів на 17,1 % в умовах інтоксикації експериментальних щурів хлоридом алюмінію, що обґрунтовує необхідність використання лікувально-профілактичних засобів пародонтопротекторної дії.
РОЛЬ ВІТАМІНУ D В ПАТОГЕНЕЗІ РОЗВИТКУ СТОМАТОЛОГІЧНИХ ЗАХВОРЮВАНЬ У ДІТЕЙ
Authors: Сухомейло Д.О. , Рейзвіх O.Е. , Христова М.Т.
Published: October 2023

Мета роботи. Виконати аналіз наукових публікацій щодо вивчення взаємозв’язку недостатності вітаміну D із хворобами порожнини рота у дітей. Матеріали та методи. Проведено аналіз публікацій баз даних Web of Sciense, SpringerOpen, Structure (NCBI), HINARI, PudMed, Scopus з використанням комбінації ключових слів: «дефіцит вітаміну D», «пародонтит», «слизова оболонка порожнини рота», «vitamin D deficiency», «oral mucosa», «periodontitis». Світові дослідження останніх десятирічь демонструють глобальний характер проблеми недостатності вітаміну D. Рівень вітаміну D привертає все більше уваги в галузі здоров’я ротової порожнини. У дітей низький рівень вітаміну D може викликати порушення мінералізації зубів, що призводить до збільшення ризику виникнення та прогресування карієсу зубів. Крім того, результати декількох сучасних доклінічних і клінічних досліджень розкрили потенційні шляхи, через які вітамін D може впливати на стан пародонту. Рівень вітаміну D також може бути пов’язаний з розвитком інших стоматологічних захворювань, такими як ортодонтична патологія, захворювання слизової оболонки, певні види раку порожнини рота. Цей огляд присвячен різним проявам дефіциту вітаміну D та його ролі у розвитку стоматологічної патології у дітей та має на меті підсумувати, як рівень вітаміну D може перешкоджати розвитку захворювань ротової порожнини, що визначає необхідність використання цього вітаміну в активній профілактиці стоматологічних захворювань. Висновки. Стан харчування дітей в Україні сьогодні не завжди є збалансованим, характеризується надлишком енергії і білків та недостатньою кількістю вітамінів і мінералів. Враховуючи дефіцит макро-та мікронутрієнтів у продуктах харчування, діти потребують додаткової нутрітивної підтримки, що необхідна для їх здоров’я та розвитку. Недостатність вітаміну D викликає в організмі чималу кількість метаболічних відхилень, які є можливою причиною низки стоматологічних захворювань. Аналіз опублікованих даних свідчить про необхідності індивідуального підходу, з урахуванням фізіологічних особливостей, індивідуальних вимог і способу життя дітей, яким проводиться профілактика дефіциту вітаміну D. Перспективи подальших досліджень. Проблему впливу рівня вітаміну D на стоматологічне здоров’я дітей необхідно продовжувати вивчати надалі, розглядаючи біохімічні, біофізичні, морфологічні, молекулярно-генетичні та клініко-епідеміологічні аспекти.
Maintaining Integrity and Expanding Authority: The Role of Ulama Women in Madura
Authors: Zain Naura Safira Salsabila , Anoraga Bhirawa , Irsyadulhaq Irsyadulhaq
Published: October 2023

In Indonesia, religious authorities are viewed as one of the most influential figures due to the number of pesantren alumni who play important roles in society. As in Madura, religious authorities are the obvious figures within the puritanical, conservative community with a strong religious attachment community. Meanwhile, Ulama women are viewed to have a limited role due to the adoption of patriarchal culture in Madura. In fact, in this modern era, there has been an important transformation done by Ulama women in strategizing daʿwa to significantly influence the ummah, which will be discussed in this research. This paper will first elaborate on the social background, the authority of religious figures, and the roles of women in Madura to broadly observe the role of Ulama women in maintaining their integrity and expanding their authority. The methodology applied in this research is qualitative, with a study case approach in Sampang, Madura. Data are collected from interviews as primary sources and articles related to the topic from books, journals, and documents as secondary sources. The framework used in the research is the concept of new Muslim womanhood in assessing the transformation to increase the reliability and validity of the research.
Social Education in The Perspective of The Qur'an (A Study of Comparative Tafsir by Al-Maraghi and Qurthubi)
Authors: Rofiqi Rofiqi , Sugianto Hendi , Zainiyati Husniyatus Salamah
Published: October 2023

Al-Qur’an memandang pendidikan sosial sebagai dimensi strategis dalam sistem ajaran dan norma-norma dalam Islam. terdapat banyak ayat al-Qur’an yang memahas tentang urgensi pendidikan sosial bagi umat Islam sehingga hal ini menisyaratkan bahwa ajaran Islam sangat memperhatikan terhadap pendidikan sosial. Tujuan penelitian ini adalah untuk mengungkap konsep pendidikan sosial dalam Al-Qur’am Surat Luqman ayat 17-19 dalam perspektif Tafsir Al-Maraghi dan Tafsir Al-Qurthubi. Metode penelitian yang digunakan adalah library research di mana data/referensi utama diambil dari dua kitab tersebut dan didukung dengan jurnal-jurnal ilmiah lainnya. hasil penelitian ini menunjukkan bahwa terdapat persamaan penafsiran dan perbedaan antara  Tafsir Al-Maraghi dan Tafsir Al-Qurthubi dalam menafsirkan Al-Qur’am Surat Luqman ayat 17-19. Persamaannya adalah keduanya menegaskan bahwa manusia harus memperhatikan tata cara dan perilaku dalam pergaulan dengan sesama, serta menjaga kesederhanaan dan merendahkan diri untuk mencapai keselarasan dalam kehidupan. Sementara perbedaanya adalah penekanan pada aspek yang berbeda dalam ayat tersebut. Kitab Al-Maraghi menekankan pada pentingnya menghindari sombong dan membangga-banggakan diri, serta pentingnya bersikap sopan santun dan baik dalam berinteraksi dengan orang lain. Sedangkan Kitab Al-Qurthubi menekankan pada tata cara berjalan di bumi yang seharusnya dilakukan dengan hati yang tulus dan rendah hati, serta pentingnya merendahkan suara dalam berbicara yang menunjukkan sikap rendah hati. Namun, pada dasarnya kedua kitab tafsir sepakat bahwa manusia harus memperhatikan tata cara dan perilaku dalam pergaulan dengan sesama, serta menjaga kesederhanaan dan merendahkan diri untuk mencapai keselarasan dalam kehidupan.
Fostering Religious Moderation Values of The Sixth Graders in Sampang, Madura
Authors: Rusdiyanto Rusdiyanto , Werdiningsih Indah , Arisandi Bustomi
Published: October 2023

The role of teachers in managing education is crucial for creating a conducive environment that fosters the development of religious moderation values. It goes beyond mere theoretical concepts within specific subjects or programs, aiming to achieve recognition that moderate education is being implemented. The objective of this research is twofold: 1) to analyze the cultivation of religious moderation values in sixth-grade learning at MI Miftahul Ulum Sampang, and 2) to describe the religious moderation values instilled in the sixth-grade students at MI Miftahul Ulum Sampang.

This research adopts a qualitative descriptive methodology with a case study design. Data collection involves interviews, observations, and documentation. Data analysis proceeds through three stages: 1) condensing the data, 2) presenting the data, and 3) drawing conclusions and verifying findings. To ensure data validity, triangulation is employed, encompassing source triangulation, technique triangulation, and time triangulation.

The findings of this research indicate that the cultivation of religious moderation values in sixth-grade learning at MI Miftahul Ulum Disanah Sampang encompasses various subjects, including thematic learning, Aqeedah (Belief) and Akhlaq (Morality), Quran and Hadith, Fiqh (Islamic Jurisprudence), Islamic Education, Science, Social Studies, and Arabic language. Furthermore, the religious moderation values identified in the sixth-grade students at MI Miftahul Ulum Disanah Sampang comprise tolerance, equality, moderation, peace, and nationalism.
Implementation of the Project-Based Learning Model (PJBL) in Islamic Religious Education Subjects Based on Merdeka Curriculum at SMKN 1 Purwosari Pasuruan
Authors: Bustomi Hadi , Yusuf Achmad , Trisnawati Diana
Published: October 2023

This research seeks to determine the process of implementing Islamic Religious Education subject based on Merdeka Curriculum at SMKN 1 Purwosari Pasuruan and the steps. This study was carried out with a qualitative method and descriptive approach. To obtain the datas, the techniques used were: in-depth interviews, observations and documentation. This study indicated that the PjBL in Islamic Religious Education subject at SMKN 1 Purwosari Pasuruan consisted of three main steps: planning step, execution step, and evaluation step. There are six main aspects on project-based learning planning: (1) formulation of learning objectives; (2) students characteristics analysis; (3) learning strategies; (4) making worksheets; (5) designing the need for learning resources; and (6) developing evaluation tools. The implementation of the project-based learning in Islamic Religious Education subject at SMKN 1 Purwosari Pasuruan have met the standards set by the George Lucas Educational Foundation on implementing project-based learning. (1) starting with essential queries; (2) designing a project plan: (3) scheduling; (4) monitoring students and their project progress; (5) assessing learning results; and (6) reflection. At the level evaluation, there are three types of evaluations: formative assessment, summative assessment and diagnostic assessment, including project evaluation
Contextualisation of Jasser Auda's Maqāṣid Sharī'ah on Hysterectomy (Surgical Removal of The Uterus)
Authors: Firmansyah Denny , Sayyaf R. Tanzil Fawaiq , Bighash Khadijeh Ahmadi
Published: October 2023

Hysterectomy (surgical removal of the uterus) is an alternative method of removing the cervix from a woman’s body through surgery. This action has implications for infertility, so the patient is sentenced to be unable to carry a fetus in the womb forever. Hysterectomy is part of a contemporary problem that requires Islamic legal policies to solve the problem. This article aims to determine the hysterectomy procedure with various backgrounds, causes, and reasons, which are interpreted contextually based on a more comprehensive maqāṣid sharī’ah perspective using the theory of a well-known contemporary intellectual figure, namely Jasser Auda. The type of research used refers to library research which is included in the qualitative realm with a descriptive-analytic approach method to produce facts from a particular phenomenon. The results of this study indicate that hysterectomy can be viewed based on context by using the maqāṣid sharī’ah system theory according to Jasser Auda through six features, namely Cognitive Nature, Wholeness, Openness, Interrelated Hierarchy, Multidimensionality, and Purposefulness.
Striding Towards Harmony: Research-Based Learning in Islamic Religious Education to Strengthen Washatiyah Islamic Values
Authors: Bahri Rosidi , Kholis Nur , Bakar Yunus Abu
Published: October 2023

The attitude of intolerance and rejection of diversity in the school environment and students is based on a narrow religious understanding and mono interpretation. Islamic Religious Education (PAI) learning, which is actually expected to be able to instil the values of Washatiyah Islam, has actually become a trigger for the entry of narrow religious views and understandings. This research seeks to discuss how PAI learning is conducted, with a Research Based Learning (RBL) approach so that the assessment can instil the values of Wahatiyah Islam. The research method was conducted through Systemetical Literature Review (SLR) using the Publish or Perish application as an identification instrument for journal articles. The articles obtained were evaluated based on the criteria of quality, novelty, and suitability to the specific research theme. The results showed that the values of Washatiyah Islam can be instilled in students through the RBL approach in PAI learning. The RBL approach is able to open students' religious thinking horizons widely through critical, analytical and collaborative learning. The RBL approach in PAI learning requires commensurate collaboration between teachers and students in order to get maximum results, especially in instilling the values of Wasshtiyah Islam
Determinant Analysis of Muslim Communities Consuming Products Halal Labeled in Bangkalan Regency
Authors: Dahruji Dahruji , Mashudi Mashudi , Yakubu Abubakar
Published: October 2023

Products labeled halal are products that have been declared halal according to Islamic law and stipulated by the Ministry of Religion through the Halal Product Assurance Agency (BPJPH) based on the results of an inspection by LPPOM MUI of the product in question, with this product labeled Halal it can meet market demands (consumers). ) universally. So if these demands can be met, economically, Indonesian business people will be able to become hosts in terms of the products being marketed. Not only that, having products labeled halal can protect the faith of consumers, especially those who are Muslim. This means that with labeling, Muslim consumers will no longer hesitate to consume something they need.Researchers used a Quantitative approach to conduct this research. This study aims to find out what factors influence Muslim communities to consume products labeled halal in Bangkalan Regency. There are several factors that can influence Muslim consumers to consume the halal label, such as religious factors, psychological factors, family factors, role and status factors, social factors, and cultural factors. The results of this research later we can find out what factors are more prominent among several existing factors that make the Muslim community in Bangkalan Regency consume products with a halal label.The results of this study from the ten initial factor variables used in this study, after analysis using factor analysis, three new factors were formed, namely: factor 1 is called the credibility factor, with the 3 members being religion, role and status, and social culture. Factor 2 is named as the knowledge factor, with the 5 members being Psychological, Family, Needs, Recommendations, Knowledge. Factor 3 is called a lifestyle factor, with the 2 members being health and lifestyle
Media Literacy: Smart in Making Islamic Content in Social Media in Sei Dadap District, Asahan District
Authors: Lakum Lakum , Lubis Nikmah , Hakim Uky Firmansyah Rahman
Published: October 2023

The rapid development of media and communication technology requires audiences to have a number of knowledge and skills called media literacy, in order to use the media correctly. The main target is teenagers. Teenagers as active users of social media need to get attention in the use of social media. Teenagers are the age of self-discovery, high curiosity, and need various education that is used as a reference. But it is very unfortunate if a teenager abuses social media, accesses and consumes media content with various social activities from various Black Mail accounts that display pornographic content / posts, provocations, and many other things that are misused into adolescent consumption that is not appropriate for his age.To prevent these negative things, teenagers need to be equipped with journalistic knowledge so that they can create Islamic creative content as an adaptive step from the use of social media. This ability needs to be possessed by teenagers, especially teenagers from Sei Dadap District. The approach used is qualitative with a descriptive nature. The results showed that Media Literacy activities in Sei Dadap District had a positive impact so that teenagers were able to choose and choose good and true news. Then it is possible to create creative Islamic content on social media as an adaptive step from the use of social media. Creating creative Islamic content on social media is also a da'wah strategy that all social media users are capable of doing. The results of this study are expected to encourage further research in the form of elaboration of media literacy theories and concepts so that they can be translated into the Media Literacy Education curriculum.