bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunometabolic Mechanisms of LANCL2 in CD4+ T Cells and Phagocytes Provide Protection from Systemic Lupus Erythematosus
Authors: Leber Andrew , Hontecillas Raquel , Tubau-Juni Nuria , Fitch Sarah N , Bassaganya-Riera Josep
Published: October 2024

Lanthionine synthetase C–like 2 (LANCL2) is an immunoregulatory therapeutic target for autoimmune diseases. NIM-1324 is an investigational new drug aimed at addressing the unmet clinical needs of patients with systemic lupus erythematosus (SLE) by targeting the LANCL2 immunometabolic pathway. In R848 and bm12 adoptive transfer models of systemic inflammation that share pathologies with SLE, Lancl2−/− mice experienced greater mortality, increased spleen weight, and reduced CD25hi FOXP3+ CD4+ regulatory T cells compared with the wild type. Conversely, treatment with NIM-1324 in the wild type increased CD25hi FOXP3+ regulatory T cells while reducing inflammatory IL-17+ and IL-21+ CD4+ T cell subsets in the spleen. In traditional mouse models of SLE (NZB/W F1 and MRL/lpr), oral treatment with NIM-1324 protected against weight loss and proteinuria, decreased anti-dsDNA titers, and provided similar changes to the CD4+ T cell compartment in the spleen. The pharmacological activation of LANCL2 by NIM-1324 rescued hypocomplementemia, reduced kidney histopathological scores, and decreased blood IFN response genes and inflammatory cytokines. The loss of LANCL2 in phagocytes impairs phagosome processing, leading to increased uptake of material and inflammatory cytokine production, yet decreased markers of endosomal maturation, phagosome turnover, and lysozyme activity. Treatment with NIM-1324 increases metabolic and lysozyme activity in the phagosome, providing support for increased markers of early phagosome function. This efficacy translated to human PBMCs from patients with SLE, because ex vivo treatment with NIM-1324 resulted in reduced levels of IFN-α, IL-6, and IL-8. Consequently, the activation of LANCL2 effectively modulates CD4+ T cell differentiation and phagocyte activation, supporting immune tolerance in SLE.
Prevalence and distribution of dry eye disease among patients with type 2 diabetes in Kosovo
Authors: Zekaj Drilon , Jerliu Naim , Kukaj-Zekaj Floriana , Tonuzi Ali
Published: October 2024

This study aimed to assess the prevalence and selected correlates of dry eye disease (DED) among patients with type 2 diabetes in Kosovo. A case-series study was conducted in Kosovo from July 2023 to July 2024, including a consecutive sample of 400 patients with type 2 diabetes aged ≥18 years seeking healthcare services at the Eye Clinic of the Clinical University Center of Kosovo in Prishtina (51% females; overall mean age: 62.4±9.7 years; response rate: 80%). Data collection consisted of a detailed clinical examination and a structured questionnaire. Almost 70% of the patients had DED (standalone or combined with retinopathy, which, in turn, had a separate prevalence of 3%). Significant positive correlates of autonomous and/or combined DED and retinopathy included older age, unhealthy dietary patterns, sedentary lifestyle, high blood pressure, and treatment of diabetes with insulin and pills. Our findings indicate a high prevalence of DED among type 2 diabetes patients in Kosovo. DED and retinopathy were strongly associated with a range of demographic factors, behavioral characteristics, and preexisting conditions pertinent to type 2 diabetes patients in this population.
Responses of Christians to COVID-19 policies: A case study of selected BONAVADA Pentecostal churches, Cameroon
Authors: Linonge-Fontebo Helen N. , Baloye Magezi E.
Published: October 2024

Background: Coronavirus disease 2019 (COVID-19) took many lives in developed countries than the Sub-Sahara. In Cameroon, the preventative measures were put in place after one case of a returning French national from Europe was tested positive. Measures included mask wearing, social distancing, prohibition of gathering of more than 50 persons, observance of hygiene measures and avoidance of close contact with other persons, as prescribed by the World Health Organization (WHO). Regardless of the prescribed strategies, infected numbers increased to 1445 on 06 July 2020. Knowledge on defiance would therefore, be helpful in future pandemics. The study availed feedback from selected churches to understand their experience and to identify determinants of adherence to the COVID-19 measures in Cameroon, given that some pastors and Christians deliberately ignored preventive measures based on religious belief and the view that defiance of social distancing practices was permissible on the grounds of faith, solidarity and love.Objectives: The article explored how selected Pentecostal churches defied the COVID-19 protocols in targeted regions of Cameroon based on faith reasons, contributing to the spread of the virus.Method: Mixed method between qualitative and desktop was employed within BONAVADA (Cameroon).Results: The defiance of some churches under study was unhelpful because the COVID-19 grew rapidly while they were attempting to resist protocols.Conclusion: Unnoticeable church defiance to protocols contributed to the spread of pandemic.Contribution: The article concretise the government strictness in case future pandemics engulf the country.
Newly qualified primary care nurses’ preparedness to make sound clinical judgements in practice
Authors: Ndlela Mavis , Downing Charlené
Published: October 2024

Background: The public health sector in South Africa provides care to more than 40 million people, with primary health care (PHC) clinics acting as most patients’ first contact with healthcare services; 80% of patients are treated by primary care nurses. Primary care nurses’ poor clinical judgment can result in poor patient care, complications and death. However, newly qualified primary care (NQPC) nurses’ preparedness for making sound clinical judgements in practice has not been evaluated in Gauteng province, South Africa.Objectives: To determine NQPC nurses’ level of preparedness in making sound clinical judgements in practice.Method: A quantitative, non-experimental, descriptive design was used. The target population was NQPC nurses. A census method was used to select all NQPC nurses in public PHC facilities in three health districts of Gauteng. The sample size comprised 77 NQPC nurses, and data were collected using a self-administered questionnaire.Results: The findings indicated that 83% of NQPC nurses were able to notice salient changes in patients’ conditions, 43% were able to correctly interpret the changes that were noticed, but only 42% prioritised the correct patient care.Conclusion: The results reflect that 50.2% of the NQPC nurses in public PHC facilities in the three districts in Gauteng were functioning at exemplary levels.Contribution: This article highlighted NQPC nurses’ level of preparedness to make sound clinical judgements within a year after qualifying.
To Study the Efficacy of Ultrasound Guided Pecto-Intercostal Fascial Plane Block in Patients Undergoing Midline Sternotomy in Open Cardiac Surgery: A Randomized Prospective Comparative Study
Authors: Singh Ganesh , Dhiraaj Sanjay , Shamshery Chetna , Agarwal Surendra Kumar , Goyal Puneet , Ambasta Suruchi
Published: October 2024

Background:

The incidence of acute poststernotomy pain after cardiac surgery is 80%1. Pecto-intercostal fascial plane block (PIFB) adjacent to the sternum anesthetizes the anterior cutaneous branches of the intercostal nerves and may provide effective analgesia after sternotomy.

Methodology:

A randomized controlled, double-blinded, prospective comparative trial was conducted at a tertiary care center on patients of midline sternotomy between 18 and 65 years and NYHA Class 2 and 3 for open cardiac surgery with the primary aim to evaluate analgesia on deep breathing after 3 hours of PIFB block bilaterally. A total of 60 patients were enrolled and randomly divided into three groups. PIFB was administered bilaterally before extubation, with 15 ml 0.125% bupivacaine plain (Group B), and bupivacaine+ clonidine 0.25 mcg/kg (Group B+C). Group C did not receive any intervention. All patients received acetaminophen 1 gram three times a day and injectable tramadol 1 mg/kg as a rescue analgesic.

Results:

Baseline characteristics were similar among all the groups. The Numeric Rating Scale (NRS) for pain was statistically lower (P < 0.05) in Groups B and B+C compared to Group C at rest, deep breathing, and coughing at 3, 6, and 12 hours after extubation. NRS on deep breathing in Groups B, B+C, and C was {(2.3, 1.5, 4.4) at 3 hours, (2.3, 1.6, 4.3) at 6 hours, (2.8, 2.1, 3.9) at 12 hrs, and {(4.3, 3.5, 3.6)} at 24 hours after extubation. The peak expiratory flow rate was the highest in Group B. Rescue analgesia was not required in Group B.

Conclusion:

PIFB reduces sternotomy pain compared to the control group on deep breathing at 3 hours after block, with delayed requirement of rescue analgesia and improved respiratory mechanics in terms of peak expiratory flow rate at all time points. There is no benefit from adding clonidine.
ProtekDuo Cannula for Pre-, Intra-, and Postoperative Lung Transplantation Management
Authors: Ricks William A. , Rackauskas Mindaugas , Weir William B. , Emtiazjoo Amir M. , Saha Biplab K. , Gries Cynthia J. , Maybauer Marc O.
Published: October 2024

We present a 61-year-old patient with pulmonary hypertension, acute respiratory failure, and acute severe right ventricular (RV) dysfunction. Preoperatively, a ProtekDuo® was inserted for extracorporeal membrane oxygenation (ECMO) and RV protection with venopulmonary (VP) ECMO in (dl) V-P ECMO configuration. Intraoperatively, it provided venous drainage for venoarterial (VA) ECMO in (dl) VP-/AO configuration for bilateral orthotopic lung transplantation (BOLT). Postoperatively, the patient remained on (dl) V-P ECMO for RV support and was decannulated with mild RV dysfunction after 5 days. This is the first description of the ProtekDuo® used in (dl) V-P to (dl) VP-/AO to (dl) V-P configuration for the entire perioperative period of BOLT.
Cross-fused Ectopic Kidney in a Term Neonate
Authors: Raghavendra Prashanth Ranya , Nathan D. Muthu Vijaya , Nair Sruthi , Haribalakrishna Anitha
Published: October 2024

We report on a term neonate with a birthweight of 2300g antenatally suspected to have an absent left kidney. Postnatally the right kidney was palpable, and ultrasound confirmed an enlarged right kidney with obstruction at the pelvic-ureteric junction and multiple renal cysts. The left kidney had an unusual appearance with its upper pole cross-fused with the lower pole of the left kidney suggestive of a cross-fused kidney, with the ureter of the crossfused kidney joining the bladder on the left side. The cross-fused kidney also showed pelvicalyceal dilatation and cystic changes’ and DMSA scans confirmed the non-functioning of the crossfused kidney with a normally functioning right kidney. MCU was normal. The neonate remained hemodynamically stable throughout the NICU stay with normal blood pressure and renal function tests. He is currently 6 months old and on regular follow-up with normal growth development. We describe the approach and management of this rare condition of crossfused kidney.
Incidence and Risk Factors of Early-onset Sepsis among Preterm Infants in a Teaching Hospital: A Retrospective Cohort Study
Authors: Al-Wassia Heidi Kamal , Saeedi Fajr A.
Published: October 2024

Introduction:

Early-onset sepsis (EOS) is associated with a high risk of mortality and morbidity, which are increased in preterm infants. We aim to assess the incidence and factors associated with increased risk of EOS among preterm infants.

Methods:

We conducted a retrospective cohort study at King Abdulaziz University Hospital, a tertiary and teaching hospital in Jeddah city. We included preterm infants <37 weeks of gestational age (GA) who were admitted to the neonatal intensive care unit. Those with congenital anomalies were excluded from the study.

Results:

We included 335 preterm infants, out of which 21 (6.3%) were diagnosed with EOS. Preterm infants with EOS had significantly lower GA (P < 0.001), birth weight (P = 0.024), and APGAR scores at 1 (P = 0.024) or 5 min (P = 0.007). More preterm infants with EOS were born outside the hospital (P < 0.029) and had significantly higher C-reactive protein (P = 0.016). Mortality was significantly higher in preterm infants with EOS compared to those without (42.9% vs. 7.3%, P < 0.001). Our multivariate regression analyses showed that decreased GA (P = 0.006) and delivery outside the hospital (P = 0.011) were associated with an increased risk of EOS in preterm infants.

Conclusion:

We identified risk factors that are significantly associated with EOS in preterm infants and should be considered to improve neonatal outcomes.
Positive Pressure Ventilation in Preterm Babies after Continuous Positive Airway Pressure Failure with or without a Tube? A Randomized Controlled Trial
Authors: Krishnegowda Sushma , Thandaveshwara Deepti , Shah Jacqueline Antoinette , Doreswamy Srinivasa Murthy
Published: October 2024

Background:

Intermittent positive pressure ventilation is a nonphysiological mode of respiratory support. Clinician‐determined parameters such as peak inspiratory pressure, positive end‐expiratory pressure, and respiratory rate will drive the gas into the lungs (driving pressure). In contrast, continuous positive airway pressure (CPAP) is a physiological mode of respiratory support where normal tidal breathing of the neonate is responsible for the movement of gas into the lungs and CPAP reduces the work of breathing by improving the functional residual capacity of the lungs. In this study, we have compared two different modes of intermittent positive pressure ventilation in babies who cannot be managed on CPAP.

Objective:

The objective of the study was to find out the difference in duration of the driving pressure support between NIPPV and continuous mechanical ventilation (CMV) in babies who fail CPAP.

Methodology:

Preterm neonates with respiratory distress who failed CPAP were randomized to either NIPPV or CMV support. The duration of driving pressure support needed in these two groups was compared.

Results:

The median (interquartile range) duration of driving pressure ventilation in the CMV group was 49.5 (24–71) hours and that in the NIPPV group was 48 (29.5–62.5) hours, which was not statistically significant (P = 0.89).

Conclusion:

The duration of driving pressure support is similar in both NIPPV and CMV modes of ventilation in babies with respiratory distress beyond CPAP.
Effect of Human Milk Fortifiers, Medium-chain Triglyceride Oil, Minerals, and Vitamin Supplements on the Osmolality of Pasteurized Donor Human Milk
Authors: Basany Laxman , Ali Abid , Priyanka G. Naga , Kulkarni Ajay B. , Tabassum Mahevish
Published: October 2024

Aim:

We aimed to study the changes in osmolality of pasteurized donor human milk (PDHM) after the addition of four human milk fortifiers (HMFs), medium-chain triglyceride (MCT) oil, minerals, and vitamin supplements commonly used in neonates.

Methods:

The osmolality of 25 ml of PDHM was measured after the addition of 1 g each of HMF and 0.5 ml of MCT oil separately with a calibrated osmometer. The osmolality of 5 ml of PDHM was measured after the addition of minerals and vitamin supplements in therapeutic doses separately. All these measurements were carried out at 10 min, 30 min, and 2 h by a technician who was blinded to the fortifiers, minerals, and vitamin supplements used.

Results:

The osmolality of PDHM was 256 mOsm/kg (range = 256–259 mOsm/kg), which increased with all four HMFs tested, but remained below 450 mOsm/kg as recommended by the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN). Proprietary fortifiers increased the osmolality of PDHM to a maximum of 429 mOsm/kg (range = 306–429 mOsm/kg). However, there was no change in the osmolality with MCT oil. A maximum increase in osmolality was observed with the addition of calcium phosphate syrup to PDHM (1181 mOsm/kg). The addition of multivitamins and Vitamin D3 in therapeutic doses increased osmolality (range = 552–753 mOsm/kg) beyond the safety limits of ESPGHAN recommendation.

Conclusions:

HMFs increased the osmolality of PDHM but were within the safety limits of ESPGHAN recommendation. MCT oil did not affect the osmolality of PDHM. Minerals and vitamin supplements added in therapeutic dosages significantly increased the osmolality of PDHM. Minerals and vitamin supplements need to be appropriately diluted to keep osmolality below 450 mOsm/kg to ensure safety. Future research should focus on manufacturing fortifiers and supplements with low osmolality to ensure safety.
Immunoglobulins as Tools for Passive Immunization in Preventive Healthcare
Authors: Olaniyan Mathew Folaranmi , Muhibi Musa Abidemi
Published: October 2024

Immunoglobulins have emerged as an important tool in passive immunization for the prevention and treatment of infectious diseases. Immunoglobulins are the proteins produced by B cells that bind to specific pathogens, neutralize them, and facilitate their removal by the immune system. In preventive healthcare, immunoglobulins are used for primordial, primary, secondary, tertiary, and quaternary prevention of infectious diseases. This work was designed to carry out an extensive literature search to provide useful information on immunoglobulins as the tools of passive immunization in preventive healthcare. Relevant and accurate literatures were sourced from the World Health Organization. Centers for Disease Control and Prevention, National Center for Disease Control, PubMed, Scopus, PLoS One, and NATURE journals: Primordial prevention aims to prevent the emergence and spread of risk factors for infectious diseases. Immunoglobulins can be used to prevent the spread of infectious diseases by targeting the pathogens that cause them. The primary prevention aims to prevent the initial infection of individuals at risk of acquiring infectious diseases. Immunoglobulins can be used as prophylaxis to prevent the onset of infection in high-risk individuals. The secondary prevention aims to reduce the severity and duration of infectious diseases. Immunoglobulins can be used to treat infectious diseases and prevent complications. The tertiary prevention aims to prevent the recurrence and complications of infectious diseases. Immunoglobulins can be used to prevent the recurrence of infections in individuals who have already been infected. Quaternary prevention aims to prevent the overuse, misuse, and abuse of medical interventions. Immunoglobulins can be used to prevent the development of antibiotic resistance by reducing the use of antibiotics. However, the use of immunoglobulins in preventive healthcare is not without challenges. The cost-effectiveness of immunoglobulin therapy, long-term safety, and the potential for cross-infection are some of the challenges that need to be addressed. Further research is needed to optimize the use of immunoglobulins in preventive health-care delivery. Immunoglobulins are valuable tools in passive immunization for the prevention and treatment of infectious diseases in preventive healthcare. Their use can help reduce the burden of infectious diseases and improve public health outcomes. Keywords: Immunoglobulins, passive immunization, preventive healthcare.
Swachh Bharat Mission and Municipal Reforms in India
Authors: Kumar Raman , Atreya Shrikant Yegneswaran , Grover Alka
Published: October 2024

As India advances toward its aspirations of a cleaner nation, integrating the Swachh Bharat Mission (SBM) with effective municipal reforms will be critical in ensuring sustainable sanitation practices that benefit all citizens, ultimately leading to improved public health and enhanced quality of life. The SBM is closely intertwined with municipal reforms, which are essential for the efficient implementation of sanitation programs at the local level. This editorial explores the SBM’s objectives, its impact on municipal reforms, the challenges faced, and the way forward.
Prevalence and risk factors of symptomatic venous thromboembolism in distal femur fractures
Authors: Mao Wei , Lim Joel Xue Yi , Tan Jiong Hao , Chang Shi-Min , Hong Choon Chiet
Published: October 2024

Introduction:

There is a paucity of published research on symptomatic venous thromboembolism (sVTE) after distal femur fractures (DFFs). This study aimed to explore the prevalence and risk factors of sVTE in DFFs.

Methods:

We identified a total of 131 patients who underwent DFF surgeries without routine pharmacological thromboprophylaxis between October 2007 and November 2016. Cases of sVTE included symptomatic pulmonary embolism (sPE) and symptomatic deep vein thrombosis (sDVT). Patients with sVTE were compared to those without, and differences in demographics and fracture-related characteristics were explored. Multivariate logistic regression was used to eliminate confounding factors.

Results:

Of the 131 patients, 20 (15.3%) had sVTE, of whom 16 (12.2%) had sDVT and six (4.6%) had sPE (two patients had both sPE and sDVT). Notably, 17 (85.0%) sVTE patients were aged ≥60 years, while only 62 (55.9%) non-sVTE patients were aged ≥60 years (P = 0.014). Fourteen (82.4%) patients with sVTE had body mass index (BMI) ≥25 kg/m2, while 49 (53.3%) patients without sVTE had BMI ≥25 kg/m2 (P = 0.032). Multivariate logistic regression demonstrated that age ≥60 years (adjusted odds ratio [OR] 5.05; P = 0.040) and BMI ≥25 kg/m2 (adjusted OR 3.92; P = 0.045) were independently associated with a higher risk of sVTE after DFF.

Conclusion:

The prevalence of sVTE in DFFs is high at 15.3%. Advanced age (≥60 years) and being overweight (BMI ≥25 kg/m2) were two independent risk factors for sVTE in DFFs. The use of routine pharmacological thromboprophylaxis should be considered as a preventative measure.
Association between treatment resistance and cognitive function in schizophrenia
Authors: Sun Jiaqian , Yee Jie Yin , See Yuen Mei , Tang Charmaine , Zheng Shushan , Ng Boon Tat , Lee Jimmy
Published: October 2024

Introduction:

Treatment-resistant schizophrenia (TRS) affects around 30% of individuals with schizophrenia. About half of the patients with TRS who are treated with clozapine do not show a meaningful clinical response, that is, clozapine resistance. To date, the relationship between cognitive function and treatment response categories is not entirely clear. This study evaluated the cognitive performance across subgroups stratified by treatment response, and we hypothesised that cognitive impairment increases with increased treatment resistance.

Methods:

This study was conducted at the Institute of Mental Health, Singapore, and included healthy controls and people with schizophrenia categorised into these groups: antipsychotic-responsive schizophrenia (ARS), clozapine-responsive TRS (TRS-CR) and clozapine-resistant TRS (ultra-treatment-resistant schizophrenia [UTRS]). Cognitive function was assessed using the Brief Assessment of Cognition-Short Form. Symptoms were measured with the Positive and Negative Syndrome Scale (PANSS). The planned statistical analyses included adjustments for covariates such as age, sex, PANSS scores and antipsychotic dose, which might affect cognitive function.

Results:

There were significant differences in overall cognitive performance between the groups: ARS had the least impairment, followed by TRS-CR and UTRS. Antipsychotic dose, and PANSS negative and disorganisation/cognitive factors were significant predictors of overall cognitive function in all patient groups.

Conclusions:

Our study found differences in cognitive function that aligned with levels of treatment resistance: the greater the degree of treatment resistance, the poorer the cognitive function. Interventions to improve negative and disorganisation symptoms might be effective to enhance the cognitive function and treatment outcomes in schizophrenia.
Comprehensive synthesis of mHealth interventions in psychiatry: insights from systematic, scoping, narrative reviews and content analysis
Authors: Mahreen Zaakira Shahul Hameed , Zainuldin Noor Azziah , Zhang Melvyn Weibin
Published: October 2024

Introduction:

Mobile health (mHealth) technologies, including smartphone apps and wearables, have improved health care by providing innovative solutions for monitoring, education and treatment, particularly in mental health.

Method:

This review synthesises findings from a series of reviews on mHealth interventions in psychiatry. Publications were systematically searched in PubMed, MEDLINE, PsycINFO, ScienceDirect, Scopus, Web of Science and Cochrane Library.

Results:

Out of 2147 records, 111 studies from 2014 to 2024 focusing on anxiety and depression were included. These studies highlight the effectiveness of mHealth interventions in reducing symptoms through cognitive–behavioural therapy, mindfulness and psychoeducation, benefitting adolescents, perinatal women and marginalised groups. Additionally, mHealth shows promise in managing substance use disorders and severe mental illnesses like schizophrenia, bipolar disorder and psychosis.

Conclusion:

Despite positive outcomes, challenges such as data privacy, user engagement and healthcare integration persist. Further robust trials and evidence-based research are needed to validate the efficacy of mHealth technologies.
Knowledge, attitude, and practice study of pharmacovigilance in a dental teaching institute in Western India
Authors: Venkatesh Rashmi , Poonacha K. S. , Vassandacoumara Vishnavee , Ajithkrishnan C. G.
Published: October 2024

Background:

India started the National Programme of Pharmacovigilance in 2005, which was renamed as Pharmacovigilance Programme of India in 2010. This is the main portal for detecting and reporting the adverse effects of drugs.

Aim:

This study aimed to evaluate the knowledge, attitude, and practice (KAP) of pharmacovigilance (Pv) in a dental teaching institute in Western India.

Materials and Methods:

The KAP questionnaire regarding Pv was distributed among the dental faculties. The knowledge-based questions were corrected and the scoring was given as excellent knowledge, good knowledge, fair knowledge, and poor knowledge for the scores between 0–5, 6–10, 11–15, and 16–20, respectively. Descriptive statistical analysis was performed which is presented as frequencies (n) and percentages (%) in all three sections of the questionnaire.

Results and Observations:

The knowledge of 24 (44%) participants was found to be fair with scores between 6 and 10. The knowledge of 23 (42%) participants was found to be poor with scores between 0 and 5 and the knowledge of 8 (14%) participants was found to be good with scores between 11 and 15. A positive and promising attitude was exhibited by the dental faculties toward reporting adverse drug reactions (ADRs). Only two study participants had reported an ADR event.

Conclusion:

The deficiencies in knowledge appear to be the underlying factor for the underreporting of adverse reactions encountered by dental practitioners.
A scoping review on the potential of three-dimensional bioprinting in auricular cartilage regeneration
Authors: Ibrahim Eman Assem , Sarhan Moamen Mohsen , Ezzelarab Salah , Marei Mona K.
Published: October 2024

Background:

The human ear significantly influences facial appearance. Auricular abnormalities can arise from many causes, and the cartilage cannot self-regenerate. Three-dimensional (3D) printing and computer-aided design/computer-aided manufacturing technology are used to create auricular prostheses through various methods to mirror the healthy ear. Despite advancements, challenges such as natural skin tones and growth accommodation persist. Bioprinting, using “Bioink” for precise cell placement, offers promising improvements for cartilage replacement and personalized auricular tissue regeneration.

Aim:

This review discussed recent and groundbreaking research in regenerative medicine for the auricular cartilage. The clinical studies of 3D bioprinting are the main topic of this review. This review aimed to clarify the transition from 3D printing of auricular prostheses to 3D bioprinting of patient-specific auricular tissues.

Methods:

The literature underwent a scoping review, making use of the keywords “Bioink, maxillofacial prosthetics, patient need, maxillofacial, additive manufacturing, auricular prosthesis, 3D bioprinting AND auricle, 3D bioprinting, auricle, cartilage, and Clinical applications of 3D bioprinting of auricle in children’s patients. Researchers searched the Cochrane, Google Scholar, ScienceDirect, and PubMed databases. Studies using cell-laden, 3D bioprinted constructs, Bioink containing living cells, or interventions to regenerate cartilage or auricle tissue, as well as the use of tissue-engineered 3D bioprinting in the maxillofacial regions, primarily in children, were included. Full texts, abstracts, and titles were all previewed. Significant groundbreaking studies were included after reference searching. The search timeline was between 2018 and 2022.

Results:

A total of 242 papers were assessed for title and abstract, with 13 judged appropriate for inclusion. Ninety-nine articles were removed, primarily because they were off-topic (unrelated) or not in English. A total of 13 publications were considered for study.

Conclusions:

Recent research has shown the potential of 3D bioprinting for tissue regeneration in both in vitro and in animal models. Human studies that have implanted 3D bioprinted auricles are still in their initial stages; however, the results are promising.
Evaluation of content usefulness and quality of YouTube™ videos as an information source for maxillofacial prosthesis
Authors: Koul Rishu , Gowda E. Mahesh , Upadhyay Guruprasada , Kalia Deepak , Verma Kamal
Published: October 2024

Background:

Social media platforms such as YouTube™ have become a widely popular source for information regarding health-related issues about medical and dental issues. The simplicity of online watching has concealed the drawback that these videos are not regularly reviewed or checked for their suitability as educational resources for dental professionals and students.

Aim:

The purpose of the current study was to evaluate the content and quality of videos on YouTube™ regarding maxillofacial prosthesis as a source of learning by dental professionals.

Materials and Methods:

Fifty-one videos satisfying inclusion criteria were watched and carefully reviewed. After that, the following data were recorded in terms of domain in maxillofacial prosthesis: number of views, likes, comments, subscribers of the channel, viewing rate, duration since upload of video, video length/duration, primary purpose of videos, video sources, target group of video, video content, video content usefulness score, modified discern instrument score, and global quality score.

Results:

No misleading video about said topic was uploaded during the period. Only 5.9% of the YouTube™ videos on maxillofacial prostheses were good.

Conclusions:

There is a dearth of good-quality videos and videos about maxillofacial prosthesis maintenance, which raises questions if maxillofacial videos on YouTube™ would be equally beneficial for patients.
Hydrodynamic limit for the non-cutoff Boltzmann equation
Authors: Cao Chuqi , Carrapatoso Kleber
Published: October 2024

This work deals with the non-cutoff Boltzmann equation for all types of potentials, in both the torus

\mathbf{T}^{3}

and in the whole space

\mathbf{R}^{3}

, under the incompressible Navier–Stokes scaling. We first establish the well-posedness and decay of global mild solutions to this rescaled Boltzmann equation in a perturbative framework, that is, for solutions close to the Maxwellian, obtaining in particular integrated-in-time regularization estimates. We then combine these estimates with spectral-type estimates in order to obtain the strong convergence of solutions to the non-cutoff Boltzmann equation towards the incompressible Navier–Stokes–Fourier system.
Foreign allegiance and constitutional citizenship: postcolonial (dis)continuities in the Commonwealth Caribbean
Authors: Jacob-Owens Timothy
Published: October 2024

The independent states of the Commonwealth Caribbean – all of them former British colonies – share a common constitutional provision, according to which individuals are disqualified from standing for election if they are under a voluntary acknowledgment of allegiance to a foreign state. In this article, I argue that judicial interpretations of this ‘foreign allegiance disqualification’ have been decisively shaped by inherited ideas drawn from the English medieval and British imperial laws of subjecthood. The first of these ideas is the assumption that holding citizenship of a state necessarily gives rise to allegiance to that state. The second is the notion that citizenship and allegiance are singular and uniform across the former territory of the British Empire, now the Commonwealth of Nations. The third is the conception of the relationship between the citizen and the state as hierarchical and quasi-contractual, wherein the citizen’s allegiance is extracted in return for the protection of the state. The region’s post-independence constitutional citizenship jurisprudence thus remains more ‘Commonwealth’ than distinctively ‘Caribbean’ in character, with the consequence that the boundaries of democratic membership continue to be defined by reference to a conceptual framework of the former coloniser’s making.
Początki i rozwój technologiczny artylerii ogniowej i jej wykorzystanie w średniowiecznych działaniach wojennych
Authors: Niewiński Andrzej
Published: October 2024

This article attempts to trace the development of artillery since the appearance of black powder in Europe. Gradually, the process of gunpowder production was improved by purification of its ingredients and selecting the right proportions. Cannons became the next stage in the evolution of the former throwing machines. In order to produce them, suitable metal alloys were discovered, and the art of gunfounding was perfected. The use of iron and lead projectiles instead of stone projectiles made it possible to reduce their size and enhance their striking power. Initially not very effective, the new weapons became increasingly significant in battle outcomes, playing a key role in events such as the capture of Constantinople or the end of the Hundred Years’ War.
PELATIHAN PENYUSUNAN LAPORAN KEUANGAN SEDERHANA BAGI KELOMPOK USAHA EKONOMI PRODUKSI NGUDI LESTARI BINAAN KANTOR DESA KEMBANG KAPANEWON NANGGULAN KABUPATEN KULON PROGO YOGYAKARTA
Authors: Susiani Rini , Yusuf Paulus Sugianto , Ilyas Supriyanto , Agustina Ingrid Larasati , Apriliana Tria
Published: October 2024

Widyatama University in collaboration with the Kembang Kapanewon Nanggulan Village Office, Kulon Progo Regency, Yogyakarta, provided Training on Preparing Simple Financial Reports for the Ngudi Lestari Production Economics Business Group to gain knowledge and skills so that they can provide guidance and assistance to the Production Economics Business Group under the supervision of the Village Office. The right suggestions and solutions will help solve the problems faced by business people, who generally have low education and insufficient expertise
PEMANFAATAN TIKTOK DALAM STRATEGI PEMASARAN: STUDI KASUS NAUGHTY INDONESIA DAN PELATIHAN TIM PEMASARAN DIGITAL
Authors: Felix Antonius , Yurisca Devi , Kembau Agung Stefanus , Sutrisno Julius , Maitri Fandevi
Published: October 2024

The use of social media, especially TikTok, has become an effective strategy for Naughty Indonesia in expanding its marketing reach and building close relationships with consumers. Through a proactive and creative approach, Naughty Indonesia has succeeded in building a strong brand image and increasing brand awareness among consumers. The training held for Naughty Indonesia's digital marketing team in the use of TikTok Ads also provided a deep understanding of the platform's potential as an effective marketing tool. The evaluation results showed a positive response from participants, with the majority giving a positive assessment of the quality and benefits of the activity. However, there are suggestions and inputs for further improvement and development, such as improved experiential practices and material development. In conclusion, this dedication succeeded in providing new insights for Naughty Indonesia in utilizing TikTok as an effective marketing strategy in the digital era. This not only provides benefits for the company, but also for the development of digital marketing team competencies in facing challenges and opportunities in the ever-evolving business world
PERAN BADAN USAHA MILIK DESA (BUMDES) BANGUN GLOBAL PRESTASI DALAM MENINGKATKAN KESEJAHTERAAN MASYARAKAT DI DESA BURANGKENG KECAMATAN SETU KABUPATEN BEKASI
Authors: Yusriyah Wanda , Sudadio Sudadio , Rawita Ino Sutrisno
Published: October 2024

Community empowerment is one way to make big changes for rural communities. Empowerment is carried out to create an independent society. A Village-Owned Enterprise (BUMDes) is a village economic institution managed by the community and village government whose aim is to improve community welfare, and to improve the community's standard of living through the economy. This research was conducted to reveal (1) What is the role of Village-Owned Enterprises (BUMDes) in improving the welfare of the people of Burangkeng Village, Setu District, Bekasi Regency, (2) What are the results of Village-Owned Enterprises (BUMDes) in improving the welfare of the people of Burangkeng Village, Setu District, Bekasi Regency , (3) What factors support and hinder the running of Village-Owned Enterprises (BUMDes) in improving the welfare of the people of Burangkeng Village, Setu District, Bekasi Regency. This research uses a qualitative approach with descriptive methods. The data collection techniques used were observation, interviews and documentation. The data sources in this research were obtained from 7 informants consisting of 1 Village Head, 1 Village Secretary, 1 Director of BUMDes Bangun Global Prestasi, 2 business actors in BUMDes, and 2 village residents. The research results explain that BUMDes Bangun Global Prestasi in Burangkeng Village is a village business institution that plays a role in facilitating economic activities, marketing community products, and empowering the community. The role of BUMDes Bangun Global Prestasi can be said to be quite instrumental in improving the welfare of village communities, but it is not optimal because there is still inequality of welfare between village communities. This is due to the many obstacles, namely lack of capital and even budget constraints, human resources for managing BUMDes are still lacking, and the socialization carried out is still uneven
PEMBERDAYAAN SANTRI MELALUI PEMBUATAN PRODUK SABUN ALOEVERA DAN STRATEGI BAURAN PEMASARAN
Authors: Suharyati Suharyati , Yeti Fitri , Utami Kery
Published: October 2024

Pondok Pesantren Al Misbah in Ciseeng, Bogor, integrates religious education with practical skills development to enhance economic self-sufficiency. A service team from the Faculty of Economics and Business at UPN Veteran Jakarta identified opportunities for empowering students by developing aloe vera soap products and their marketing strategies. Aloe vera was chosen for its health and beauty benefits. The aim of this service project is to enhance the economic independence of the students and to broadly introduce the product. The solutions offered include training in the production of aloe vera soap and marketing strategies. Data testing results showed adequate validity and reliability. The activity involved 32 students out of a total of 40, comprising 53% males and 47% females. Through tests, the participants' understanding of marketing strategies and the benefits of aloe vera exceeded the expected target, reaching 87% and 86%, respectively. Moreover, based on the three-box method index calculation, the index value falls in the high category. However, further evaluation is necessary to ensure participants achieve maximum understanding
PEMANFAATAN MEDIA SOSIAL DALAM PENYAMPAIAN INFORMASI DAN KONSULTASI HUKUM OLEH MAHASISWA HUKUM
Authors: Aslami Iron Fajrul , Tiara Erika Prima , Purba Martinius Rambe
Published: October 2024

Bina Bangsa University Law Faculty students took the initiative to provide community service through legal consultations using social media. By taking advantage of advances in information technology, we have opened the door for easier and more affordable access for individuals who need legal advice or information. Through social media platforms, Law Students can share knowledge and answer questions, as well as provide free advice accompanied by law lecturers to people who need legal assistance. In this way, not only helping the community in overcoming legal problems, but also increasing legal awareness in general. As an academic activity that shows the commitment of Bina Bangsa University law students in serving and making a positive contribution to society through the use of social media as an effective service tool
PELATIHAN MANAJEMEN USAHA DAN ASPEK HUKUM TEKNIS PEMBUATAN NOMOR INDUK BERUSAHA DAN PROMOSI PRODUK MELALUI MEDIA SOSIAL DAN ELEKTRONIK PADA KELOMPOK USAHA MIKRO KECIL DAN MENENGAH (UMKM) DESA CITAMAN SERANG BANTEN
Authors: Suhandi Suhandi , Hibar Ujang , Hakim Agus Lukman
Published: October 2024

This Beginner Community Service Activity (PMP) was held in Citaman Village, Ciomas Serang District, Banten. With the target of the Citaman Village Micro, Small and Medium Enterprises (UMKM) group. The problems faced by the partners, in this case the Citaman Village MSME group, namely: ), do not know information about legal aspects and digital marketing or product promotion through electronic means and social media, still lack knowledge of science and technology in running their business. The purpose of this service is to help increase the knowledge and skills of partners, in this case the Citaman Village MSME group, in implementing business management, making Business Identification Numbers (NIB) and product promotion through social and electronic media. The results of this service activity show that the Citaman Village MSME group can apply business management, can create a Business Identification Number (NIB) and can implement product promotions through social and electronic media, there is an increase in partner businesses, so that they can increase the income and economy of existing MSME group members in Citaman Village
PELATIHAN EXCELENSI KEUANGAN SMK MENGASAH KETERAMPILAN LAPORAN KEUANGAN DENGAN SPREADSHEET
Authors: Hamzah Amir , Purnama Dendi
Published: October 2024

This community engagement initiative aimed to enhance the competence of Vocational School (SMK) students in preparing financial reports using spreadsheets. In this endeavor, we collaborated with an SMK in Kuningan Regency to organize training and practical sessions. The evaluation results demonstrated a significant improvement in students' understanding of financial reports.Before the training, the average exam score of students was 65, with only 75% of students passing the basic financial report knowledge exam. Following the training, the average exam score increased to 85, and the pass rate surged to 95%. These outcomes reflect the success of the training in improving students' comprehension and equipping them with practical skills necessary in the workforce.The significance of these results lies in the enhanced competence of SMK students in preparing financial reports, a skill highly sought after in today's business world. The success of this training attests to the tangible benefits of collaboration between educational institutions and the community in enhancing the quality of education and preparing students for their careers
APLIKASI PENGELOLAAN PENGAJUAN DANA KEGIATAN KESISWAAN DAN LAPORAN PRESTASI SISWA SMK NEGERI 11 BANDUNG
Authors: Rochmawati Rochmawati , Anak Agung Gde Agung , Rahmatika Annisa Nurdini , Jannaki Mochamad Gerda Iqbal , Alhakim Lutfi
Published: October 2024

As a secondary level educational institution, students of SMKN 11 Bandung have various activities. Because of the numerous and varied student activities, manually managing activity submissions is considered inefficient and ineffective. Various problems arise when submissions are made manually. Incompatibility of activities and errors in budget calculation are common mistakes that occur when examining applications. Another problem is that the results of activities are sometimes not properly monitored because the personnel who handle student activities are busy. This problem is the main background for the community service program. In this program, a web-based application was designed, created, and implemented to automate the management of student activity funding applications and generate student achievement reports. Activities start with requirement analysis to mentoring in using the application. Implementation of this application ensures funding applications for student activities and the generation of student achievement reports can be automated
KOLABORASI SOSIAL MEMBANGUN MASYARAKAT UNTUK MEMPERTAHANKAN KOMODITI UNGGULAN KARET ALAM DI KAB.KUATAN SINGINGI RIAU
Authors: Sunanto Sunanto , Sunaryo Sunaryo , Israyadi Israyadi , Bahrudin Bahrudin , Zahrina Ida , Yasri Indra
Published: October 2024

The Berkah Basamo Rubber Farmers Group Association (Gapoktan) in Lubuk Terantang Village already has two rubber downstream product development workshops. The Kuantan Singingi Rubber Farmers Association (APKARKUSI) has facilitated the two buildings with several equipment to support downstream rubber production, including hot press machines, molding, compressors, creeper machines, tire retreading machines, and buffing machines. Apart from that, APKARKUSI has also facilitated several people from the Lubuk Terantang Village Youth Organization to be given training in making downstream rubber products at the Industrial Research and Standardization Center (Baristand), Palembang. The problem currently faced by target partners is that the production equipment is less functional, so farmers cannot produce downstream rubber with higher economic value. Apart from that, target partners also still need more intensive assistance and training, both in the production process and marketing their products. The solutions offered in this kosabangsa program are improving the institutional structure of target partners, improving businesses initiated by partners, improving partner income and welfare
PENINGKATAN KOMPETENSI TAKHRIJ HADIS MAHASISWA ILMU HADIS UINSA SURABAYA MELALUI PELATIHAN OPTIMALISASI MAKTABAH SYAMILAH
Authors: Pratama Ferdy , Razi Fahrur , Fausi Erfan , Akbar Mochammad Rafi’i , Afifah Alvin , Diansyah Edoardo Arta , Abrori Sahal Aqil
Published: October 2024

The development of technology and information has influenced various aspects, including the scientific learning aspect of hadith. The use of this technology can go hand in hand with how students of the hadith science study program at UIN Sunan Ampel Surabaya carry out an efficient and effective process of takhrij hadith by using the Maktabah Syamilah application. Using the Maktabah Syamilah application in the hadith takhrij process can be quite helpful with the various features contained in the Maktabah Syamilah application. This training activity has three stages, namely preparation, implementation and evaluation. The methods used in this training are participation, discussion and direct practice with assistance to provide solutions to existing problems. As a result of this service, the use of technology based on the Maktabah Syamilah application provides new knowledge and skills and the process of takhrij hadith is carried out more optimally. The importance of training that supports the learning process of students in the Hadith science study program should be carried out in stages because it requires quite a lot to directly apply the various features in the Maktabah Syamilah application