bluuebunny/crossref_metadata_2025 huggingface dataset:
Islamic Education and Value Analysis of Religious Moderation in Jalaluddin Rumi's Sufi Order
Authors: Muizzuddin M. , Zaenuri Ahmad , Anam Saeful
Published: August 2024

This study aimed to investigate and analyze Jalaluddin Rumi's teachings on religious moderation and Islamic education within his Sufi tradition. A qualitative method was utilized in this study, including library study, field observations, and interviews with individuals involved in Islamic education at Pesantren. The findings revealed that Jalaluddin Rumi did not explicitly discuss the concept of religious moderation. Instead, he devoted his life to propagating Sufi values and attitudes closely aligned with Islamic beliefs, mystical knowledge (marifat), and sharia as elements of religious moderation. The values of religious moderation conveyed in Rumi's works include compassion (rahmat), humility (tawadhu), excellence (ihsan), forgiveness, mutual respect, tolerance, and peace. This study, conducted at Pesantren Raudhatul Mutta'alamin in Lamongan, illustrated the significant relevance of Jalaluddin Rumi's Sufi teachings to advancing Islamic education and promoting religious moderation in Indonesia.
Improving Islamic Religious Education Learning Outcomes Utilizing the Brain-based Learning Model Based on Students' School Origin and Cognitive Stage
Authors: Somantri Enjang Aris , Sabarudin Mohammad , Al Ayyubi Ibnu Imam , Suryana Irfan , Singh W. C.
Published: August 2024

This study aims to improve learning outcomes in Islamic religious education (IRE) utilizing the brain-based learning model based on students' school origin and cognitive stage. This study used a quantitative approach and was conducted in SMPN 1 Wanayasa Purwakarta Regency with a sample of 31 students, SMPN 2 Parongpong West Bandung Regency with a sample of 32 students, and SMPN 2 Ciampel Karawang Regency with a sample of 37 students. The research instrument was a test with data analysis requirements, consisting of a normality test and a homogeneity test, using Kolmogorov-Smirnov and Shapiro-Wilk, assisted by SPSS software version 26. It was found that there were significant differences and interactions in the IRE learning outcomes that utilized the brain-based learning model based on students' school origin in SMPN 1 Wanayasa, SMPN 2 Parongpong, and SMPN 2 Ciampel, and students' cognitive stages in the concrete, transitional, and formal categories. Therefore, further study can be carried out based on students' school origin at the Senior High School level and cognitive stage utilizing the brain-based learning model.
Comparison of Students' Mathematical Concept Understanding Ability in Polyhedron Material Using the Discovery Learning and Core Learning Model with The Assistance of Pop-Up Book Media
Authors: Azahroh Inanda Shofa , Kumala Fitria Zana
Published: August 2024

This research was motivated by the low ability of class VIII students at MTs N 1 Purbalingga to understand mathematical concepts. This research aims to compare students' ability to understand mathematical concepts in flat-sided geometric material using two different learning models, namely discovery learning and Connecting, Organizing, Reflecting, And Extending (CORE) with the help of pop-up book media. The research method used is quantitative with a quasi-experimental type of research. The population in this study were class VIII students at MTs N 1 Purbalingga for the 2022/2023 academic year. The sampling technique used simple random sampling, and the sample in this study were students in classes VIII D and VIII E, totaling 76 students. In experimental class I, I received teaching using the discovery learning model assisted by pop-up books. For experimental class II, I received teaching using the CORE model assisted by pop-up books. The data collection method uses tests in the form of pretest and posttest. The data analysis technique uses the n-gain and two independent samples t-tests. The research results showed that the average n-gain score in experimental class I was 0.656; in experimental class II, it was 0.366, which was in the medium category. Judging from the n-gain interpretation, the average percentage value obtained by experimental class I, namely 65.5%, is interpreted as quite effective. It is interpreted as ineffective in experimental class II, namely 36.6%. Based on analysis using the t-test for two independent samples, the significance value was 0.000 < α=0.05, so it can be concluded that there is a significant difference between the ability to understand mathematical concepts of students who use the pop-up book-assisted discovery learning model and the CORE assisted learning model on flat-sided building materials.
Characterization of Foundational Literacy Instruction for Early Grade Students Based on Their Skill Levels
Authors: Syarifudin Syarifudin , Nurrahmah  , Sholihin  , Widiyanti Ria
Published: August 2024

This research aims to describe the characteristics of basic literacy learning among early grade students based on their skill levels or through Teaching at the Right Level (TaRL) approach. The research subjects consist of 15 third-grade students from Rompo Elementary School. The research instruments include initial diagnostic tests and progress tests conducted during the learning process. The research findings indicate that the first level group's approach involves introducing children to the smallest components of literacy skills, namely sounds and letters, as well as distinguishing various phonetic variations of these letters. In Group B, students enhance their reading fluency through regular reading exercises, building text comprehension skills, and starting to understand unusual combinations of letters and pronunciations. Group C engages in collaborative reading within small groups, answering a series of questions about the text, drawing conclusions about the meanings of foreign words, and transitioning from simple to complex conceptual understanding. Students are encouraged to practice writing daily, read together, and evaluate each other's work to strengthen their abilities in identifying spelling errors, grammar, and common punctuation.
Development of Mathematics Learning Tools to Improve High School Students' Critical Thinking Abilities
Authors: Nurhayati  , Ruslau Maria F V , Natsir Irmawaty , Pratama Rian Ade , Asmaningrum Henie Poerwandar
Published: August 2024

This research aims to produce high school mathematics learning tools to improve students' critical thinking skills which include Student Worksheets (LKPD), and learning outcome assessment test sheets that are valid, practical and effective. The combination of learning methods and technological devices provides a fun learning process and helps students improve their critical thinking skills so as to provide benefits to students' learning outcomes. The type of research carried out is the research and development method. The development model referred to is using a 4-D development model which consists of four stages, namely the define stage, the design stage, the develop stage and the disseminate stage. The research instruments used were validation sheets, teacher practicality sheets, student practicality sheets, learning implementation observation sheets, and test sheets. The research data obtained that the level of device validity was in the valid category with an average score of 74.5. The teacher obtained a score of 60.5 for practicality and 61.88 for student practicality, so that the product met the practical category, and the results of students' mathematics learning achievement tests in the field trial showed that 83.3% of students had achieved the Minimum Completeness Criteria (KKM) so that the product The worksheet meets the effective category. Based on the obtained validity, practicality and effectiveness figures, it can be concluded that the learning tools developed are suitable for use in the classroom learning process.
Influence of The Use of Canva-Based Video Learning Media on The Mathematical Problem-Solving Ability of Class XII Students of SMA Negeri 1 Air Joman
Authors: Astuti Dewi , Saragih Eva Margaretha , Silaen Nova Eliza
Published: August 2024

This research aims to determine the effect of using Canva-based video learning media on the mathematical problem solving abilities of class XII students at SMA Negeri 1 Air Joman. This type of research is quasi-experimental with a two-group pretest and posttest research design. The population in this study were all students of class XII Science consisting of 3 classes. The research samples used were 2 classes (Class XII IPA-2 and XII IPA-3) with 30 students in each class. In class XII IPA-3 was an experimental class using Canva-based learning video media and in class XII-2 as a control class without using Canva-based learning video media. After the learning was completed, a posttest was obtained with an average result for the experimental class of 80.5 and the control class of 76.4. The t-test results obtained t_count (3.774)> t_table (2.001). H_a is accepted, thus there is a positive and significant influence in the use of Canva-based video learning media on the mathematical problem-solving abilities of class XII students at SMA Negeri 1 Air Joman.
DESIGN AND EVALUATION OF PROPOLIS-LOADED BUCCAL PATCHES
Authors: Alazzo Ali , Al-nima Amina , Al-qattan Mohammed Nooraldeen
Published: August 2024

Objective: Propolis is highly recommended in aphthous stomatitis, a condition that requires a proper delivery tool to achieve an efficient treatment. For this indication, a buccal patch that provides prolonged mucosal contact and protection would be beneficial. Accordingly, in this study, we designed propolis-loaded buccal patches, composed of three polymers (alginate, carboxymethylcellulose, and polyvinylpyrrolidone) of complementary properties, and the proper combination of them to produce the patch of optimum properties.
Material and Method: Nine patches of different polymer ratios were prepared by casting method and evaluated by assessing their swelling, adhesion time and strength, and dissolution rate. Then the patches properties were correlated using artificial neural network analysis.
Result and Discussion: The results showed that all patches were smooth, translucent, and flexible with surface pH between 6.5 and 7.4. The correlation between polymer composition and measured properties was complex and non-linear. Therefore, an artificial neural network was used to analyze these properties and optimize them. The model of this analysis provides higher weights for favorable tensile and adhesion strengths while considering swelling, rigidity, and fast dissolution rate as unfavorable. According to summation analysis, the combination of CMC% and PVP% of 15.5 and 13, respectively, provides the best score of 3.5.
OTOİMMÜN HASTALIKLARDA LUTEOLİN BİLEŞİĞİNİN ROLÜ
Authors: Işkın Ali Eren , Kızmaz Muhammed Ali , Budak Ferah
Published: August 2024

Amaç: Bitkisel gıdalarda yaygın olarak bulunan ve kristalik bileşikler olarak da bilinen flavonoidler, optik aktivite özelliği gösteren bileşiklerdir. İskelet yapılarının farklılıklarına dayalı olarak alt tipleri bulunmaktadır. Luteolin (LUT), boyacı katırtırnağı (Genista tinctoria) ve muhabbet çiçeği (Reseda luteola) bitkilerinden elde edilen önemli bir flavondur. Yapılan çalışmalarda, anti-oksidan, anti-enflamatuvar, immünomodülatör, anti-kanser ve nöroprotektif gibi birçok özellik sergilediği bildirilmiştir. LUT gibi doğal ürünlerden elde edilen bileşiklerin, kanser, otoimmün, nörodejeneratif ve kronik hastalıkların gelişiminde önemli rolleri nedeniyle çok sayıda araştırmanın odak noktası haline gelmiştir. Bu derlemedeki amacımız, otoimmün hastalıklarda LUT bileşiğinin terapötik rolünü değerlendirmektir.
Sonuç ve Tartışma: Çeşitli sebzelerde, meyvelerde bulunan ve değişken bir fenolik madde yapısına sahip olan LUT bileşiğinin; sistemik lupus eritematozus, romatoid artrit, astım, multipl skleroz, otoimmün ensefalit, ülseratif kolit, otoimmün diyabet, psoriasis, otoimmün tiroidit ve üveit gibi bazı otoimmün hastalıklarda anti-enflamatuvar, anti-oksidan, immünomodülatör ve nöroprotektif aktiviteler sergilediği bildirilmiştir. Ancak, LUT bileşiğinin toksisitesi ile ilgili endişe verici bazı bulgular da raporlanmaştır. Gelecekte yapılacak olan farmakokinetik, toksisite, kombine tedavi ve moleküler biyoloji çalışmaları LUT bileşiğinin sağlık üzerindeki etkilerini daha iyi anlamamıza yardımcı olabilir.
Penyuluhan Gaya Hidup Sehat dan Bahaya Narkoba di SMP Global Islamic School Al-Amin Gondanglegi dengan Metode Seminar dan Diskusi
Authors: Ummah Roisatul , Iza Nikmatul , Nisa Khoirun
Published: August 2024

A healthy lifestyle is a long-term lifestyle choice with a good lifestyle with a commitment to doing several things to support the body's functions, thereby providing health effects for the body, while drug abuse is drug use that is done not for medicinal purposes, but because they want to enjoy it. influence, in excessive amounts. The purpose of conducting counseling activities on healthy lifestyles and the dangers of drugs at SMP Global Islamic School Al-Amin Gondanglegi using seminar and discussion methods is to increase students knowledge and insight so that they understand the importance of maintaining a healthy lifestyle and avoiding negative things such as drugs.  Based on the target students as the target of counseling activities, it is concluded that counseling on healthy lifestyles and the dangers of drugs with lectures and discussions increases the active role of students in thinking critically about lifestyle and drug problems, besides that the counseling activities carried out add to the insight of students so that the results of counseling can be applied daily and students avoid the dangers of drugs that damage the future of the nation.
The effect of captopril on nitric oxide formation and on generation of radical forms of mitochondrial respiratory chain compounds in ischemic rat heart
Authors: Vavřínková H , Tutterová M , Stopka P , Divišová J , Kazdová L , Drahota Z
Published: August 2024

The increase of radical forms of mitochondrial respiratory chain compounds (MRCC) is an indicator of an increased risk of the formation of oxygen radicals. Using electron paramagnetic resonance (EPR), we found an increase of signals corresponding to ubisemichinone radical (·QH) and ironsulfur proteins radical forms (·FeS) of these respiratory chain compounds during ischemia in the isolated perfused rat heart (·QH increased from 1.51 to 3.08, ·FeS1 from 1.14 to 2.65 arbitrary units). During the 5-min reperfusion, the signals returned to normoxic levels. In isolated mitochondria exposed to anoxia and reoxygenation the radical forms of ·QH and ·FeS2 changed in a similar manner as in the intact heart. A combination of in vivo captopril treatment and in vitro L-arginine administration significantly decreased the levels of MRCC radicals in the isolated myocardium (·QH from 2.61 to 1.72 and ·FeS1 from 1.82 to 0.46 under normoxia; ·QH from 4.35 to 2.66 and ·FeS1 from 1.93 to 1.35 during ischemia). This decrease in MRCC radical forms was associated with increased NO levels in the perfusate, determined as NO2-/ NO3-, as well as tissue NO levels determined using EPR as the dinitrosyl iron complex (DNIC). These results provide new information about the cardioprotective effects of ACE inhibitors and L-arginine.
Nitric oxide synthase mRNA levels correlate with gene expression of angiotensin II type-1 but not type-2 receptors, renin or angiotensin converting enzyme in selected brain areas
Authors: Križanová O , Kiss A , Žáčiková Ľ , Ježová D
Published: August 2024

Recent data suggest that there is interaction between peripheral angiotensin II and nitric oxide. However, sparse information is available on the mutual interaction of these two compounds in the brain. The potential intercourse of nitric oxide with brain neuropeptides needs to be substantiated by assessing its local production and gene expression of the synthesizing enzymes involved. The aim of the present study was to evaluate whether the gene expression of brain nitric oxide synthase (bNOS) is related to the sites of gene expression of different components of the rat brain renin angiotensin system (renin, angiotensin converting enzyme (ACE) or angiotensin receptors of AT1 and AT2 subtypes). The levels of corresponding mRNAs were measured and correlated in nine structures of adult rat brain (hippocampus, amygdala, septum, thalamus, hypothalamus, cortex, pons, medulla and cerebellum). As was expected, positive correlation was observed between renin and angiotensin-converting enzyme mRNAs. Moreover, a significant correlation was found between brain NO synthase and AT1 receptor mRNAs, but not with mRNA of the AT2 receptor, ACE and renin. Parallel distribution of mRNAs coding for bNOS and AT1 receptors in several rat brain structures suggests a possible interaction between brain angiotensin II and nitric oxide, which remains to be definitely demonstrated by other approaches.
Combination of drugs elevating extracellular adenosine with granulocyte colony-stimulating factor promotes granulopoietic recovery in the murine bone marrow after 5-fluorouracil treatment.
Authors: Hofer M , Pospíšil M , Weiterová L , Znojil V , Vácha J , Holá J , Vacek A , Pipalová I
Published: August 2024

Combined administration of drugs elevating extracellular adenosine, namely dipyridamole and adenosine monophosphate, together with granulocyte colony-stimulating factor was shown to enhance granulopoietic recovery in the bone marrow of mice treated with 5-fluorouracil. Enhanced regeneration was found both at the level of hematopoietic progenitor cells for granulocytes and macrophages and in the compartment of morphologically recognizable granulocyte precursors. The results might have positive clinical impact. The adjunct use of drugs elevating extracellular adenosine might reduce the cost expenditure of therapy with granulocyte colony-stimulating factor.
Effect of ethanol on tracheal potassium channels reconstituted into bilayer lipid membranes
Authors: Komínková V , Magová M , Mojžišová A , Máleková Ľ , Ondriaš K
Published: August 2024

We examined the effect of ethanol on single potassium channels derived from plasma membranes of bovine tracheal smooth muscles. The observed potassium channels had a conductance of 296±31 pS (mean ± S.D.) in symmetrical 250 mmol/l KCl solutions, and exhibited a voltage- and Ca2+-dependence similar to BKCa channels. Ethanol at 50, 100 and 200 mM concentrations increased the probability of open potassium channels to 112±5, 127±7 and 121±13% (mean ± S.E.M.), respectively. It is suggested that increased activity of the BKCa channels by ethanol hyperpolarizes the plasma membrane and thus may contribute to relaxation of tracheal smooth muscle.
Protective effect of quercetin on ischemia/reperfusion-induced gastric mucosal injury in rats.
Authors: Mojžiš J , Hviščová K , Germanová D , Bukovičová D , Mirossay L
Published: August 2024

This study was designed to determine the gastroprotective properties of quercetin in ischemia/reperfusion-induced gastric mucosal injury and the involvement of endogenous prostaglandins in this process. Oral pretreatment of rats with quercetin (100 mg.kg-1) 30 min before surgery significantly decreased the length of gastric mucosal lesions. However, lower doses of quercetin (25 and 50 mg.kg-1) only slightly decreased the gastric mucosal injury. Intraperitoneal application of indomethacin (5 mg.kg-1) had no effect in control (sham-operated) animals, but significantly worsened gastric injury in non-treated animals after ischemia/reperfusion. Furthermore, indomethacin only slightly reversed protective effect of quercetin. Non-treated animals showed a marked decrease in adherent mucus after ischemia/reperfusion. On the other hand, application of quercetin prevented this significant decrease even in animals pretreated with indomethacin. It can be concluded that antioxidant properties of quercetin and its mucus protective effect might be the main factors responsible for its protective effect against ischemia/reperfusion-induced gastric mucosal injury.
Are They Still Traveling to Bali Following The Covid-19 Pandemic?
Authors: Liestiandre Hanugerah Kristiono , Supratayasa I Gusti Ngurah Agung , Suasapha Anom Hery , Sumariati I Dewa Ayu Rai , Ngelambong Anderson
Published: August 2024

The world has been significantly impacted by the COVID-19 epidemic, particularly in the travel and tourism sector. Even after the Covid-19 outbreak stopped, the effects in various forms continued to recur. The market segment is also affected by post-pandemic developments in the tourism industry. Geographically, changes in tourist market sectors might present new perspectives and opportunities or new challenges and risks to a tourism destination if it does not adjust quickly to these changes. This pilot study attempts to identify shifts in traveler market patterns that arise in Bali as a global travel destination following the pandemic. It illustrates how changes in market segments have occurred in this destination through tourist arrival data recorded by the National Statistics Bureau. A quantitative comparison analysis approach to the number of tourist visits reveals that there have been changes in nearly every region. The number of visitors to Bali has changed significantly in each region's tourist-generating countries. This study demonstrates that, due to various circumstances, market segment shifts have happened considerably in practically every region and every country. This study offers a crucial overview for formulating strategies and policies for growing the tourism industry after the COVID-19 outbreak.
SKRINING GEJALA MENOPAUSE MENGGUNAKAN GREENE CRIMACTERIC SCALE DI PUSKESMAS WUNDULAKO
Authors: Saputri Ekawati , Afriyanti Iis , Nasus Evodius , Tulak Grace Tedy , Susanti Risqi Wahyu , Salu Sahrul Poalahi
Published: August 2024

Menopause merupakan saat ovarium berhenti memproduksi telur dan mengakibatkan penghentian menstruasi. Seorang wanita akan mengalami transisi menopause yang akan menimbulkan gejala. Skrining gejala menopause dilakukan untuk mencatat skor gejala dan membantu menegakkan diagnosis serta menjadi dasar untuk menilai kemanjuran pengobatan. Kegiatan pengabdian masyarakat ini bertujuan menilai gejala menopause serta menjadi pedoman bagi wanita agar dapat berkonsultasi kepada dokter atau profesi kesehatan lain terkait gejala yang dialami oleh wanita. Peserta kegiatan ini adalah wanita berusia 40-55 tahun berjumlah 17 orang. Seluruh gejala menopause dirasakan ringan hingga berat. Gejala menopause yang dirasakan berat adalah jantung berdebar, sulit tidur, pusing, sakit kepala, kesemutan di beberapa bagian tubuh, gangguan saluran perkemihan dan kering pada vagina.
THE EFFECTIVENESS OF PROCYANIDIN ON RED GRAPE SEED EXTRACT IN TREATMENT OF PERIODONTITIS INDUCED BY DIABETES MELLITUS
Authors: Rachmawati Ranny , Handoko Monica Annasthasia , Avrilia Isabella , Wisnawati Angela Latisha
Published: August 2024

Introduction: Periodontal disease, including periodontitis, ranks as the 6th complication for Diabetes Mellitus. Research has found an increase of inflammation and higher alveolar bone loss in the periodontal of diabetes mellitus patients. One of the components which exhibited multiple bio-activities like anti oxidative, anti-inflammatory, antidiabetic antimicrobial cardioprotective, neuroprotective, immunomodulatory, and anti-obesity activities is procyanidin. Procyanidin can be found in various natural ingredients and one of the most abundant compositions is found in red grape seeds. Methods: The method used in this study is a literature review from several academic databases including : Google Scholar, PubMed, Mendeley, Wiley, and the university's online library with boolean searching method. Results: The several articles used in this literature review show that the protective effect of grape seed procyanidin plays a role in attenuating the increase of MFG-E8, suppressing the increase of IL-1beta protein level, improving HOMA-IR and insulin levels in diabetes, increasing IL-10 and TGF-beta accumulation in the gingival epithelium of periodontitis condition, and MMP- and HIF-1alpha immunohistochemistry showed an increase in its levels for periodontitis with diabetes rats, but decreased as grape seed procyanidin extract (GSPE) was administered. Conclusion: The present study suggested that procyanidin in grape seed extract played a role in treating periodontitis in diabetes patients through its anti- inflammatory role and its ability to decrease alveolar bone loss. There are still very few studies regarding this topic, therefore
Overview of implementation of development plans in India
Authors: Jagtap Rutuja Deshmukh , Singh Devendra Pratap
Published: August 2024

For planning and development of a city considering its infrastructure master plans or development plans are traditional instruments used. Over a period of it is realized that  percentage of implementation has received less attention than formulation. Increase in ratio of effective execution is missing in development plan. Review of development plans and analysis of its application in Indian context is discussed. Thus status of the execution of development plan with identification of barriers in its implementation is focused.
MENINGKATKAN PRODUKTIVITAS DI LINGKUNGAN KERJA INDUSTRI/PRAKERIN
Authors: Maria Evy Purwitasari  , Lutviani Metya , Muhammad Ferdinansyah  , Tri Andriani  , May Vitha Rahmadhani
Published: August 2024

To support the process of teaching and learning activities in the vocational field, one of the learning processes is carried out at the SMK level. Every student who graduates from vocational school, as well as students from SMK 1 Barunawati, is required to have skills and be ready to work because vocational school graduates are usually not recognized by the business/industry world. Therefore, a Dual System Education (PSG) program was held, namely by implementing Industrial Work Practices (PRAKERIN) so that every vocational school graduate student has experience in the business world before entering the business world for real after graduating from school. In accordance with the results of observations and research from the Directorate of Vocational Secondary Education, the pattern of implementation at Vocational Schools has not clearly been able to produce graduates as expected. This can be seen from the learning conditions which are not yet conducive to producing professional workers, because a person's professional skills are not solely measured by mastery of knowledge elements and work techniques, but must be complemented by mastery of good work skills. There are two parties, namely educational institutions and employment opportunities (industry/companies or certain agencies) which jointly organize a vocational skills program. Thus both parties should be involved and responsible.
PELATIHAN PEMANFAATAN MEDIA SOSIAL SEBAGAI PELUANG USAHA PADA UKM DI PULAU HARAPAN, KEP. SERIBU, JAKARTA
Authors: Purwaningsih Nining , Lena Erdawati  , Dede Sunaryo  , Metha Dwi Apriyanti  , Andi Kusuma Negara
Published: August 2024

Social media is now widely used in almost all companies, the reason is to reach consumers more quickly, easily and widely. Social media (Instagram, Whatsapp, Facebook, etc.) is part of digital marketing, namely product marketing efforts using digital media and internet networks. The change in marketing behavior from conventional to digital is not balanced by the existence of SMEs that use digital marketing, even though SMEs are believed to be able to stimulate the Indonesian economy. The methods used in this community service activity are training, lectures and questions and answers, and discussions. The result of this activity is to provide several solutions to be able to look for new business opportunities to maintain business continuity, namely utilizing social media. Apart from that, increasing digital marketing knowledge and increasing knowledge regarding the use of WhatsApp business social media as a sales promotion media. The conclusion of this activity is very useful for SMEs in providing suggestions, especially regarding digital marketing strategies.
Comparing the Effect of 20% Zinc Oxide Ointment With 80% Trichloroacetic Acid Solution in the Treatment of Genital Warts: A Single-Blind Randomized Clinical Trial
Authors: Yosefi Sharami Rehane , Rezaei Masoumeh , Seyedoshohadaei Fariba , Rahmani Khaled , Safar Bakhshayeshi Leila
Published: August 2024

Objectives: There are several treatment options for genital warts, but many can cause skin sensitivities or lead to a recurrence of lesions. This study seeks to compare the effectiveness of 20% zinc oxide ointment with 80% trichloroacetic acid (TCA) solution for treating genital warts. Materials and Methods: In this single-blind randomized clinical trial, 88 women with genital warts were divided into two groups of 44. Group A received treatment with zinc oxide, while group B was treated with TCA. Patients were followed up three times, at the end of the fourth, eighth, and twelfth weeks after the start of treatment, to assess the effectiveness of the treatments for genital warts. Results: The number, thickness, and diameter of genital warts decreased significantly in both groups during 12-week period (P=0.0001). However, the reduction in the number, thickness, and diameter of warts was significantly greater in the TCA group compared to the zinc oxide group (P=0.001). After 12 weeks, the TCA group achieved complete clearance of lesions in 84.1% of patients, while the zinc oxide group had a 31.7% clearance rate (P=0.001). Conclusions: Given the significantly higher rate of complete clearance of lesions achieved with TCA compared to zinc oxide, it may be a more effective treatment option and preferable in the management of genital warts.
Investigating the Therapeutic Potential of Clove Extract in Mitigating Testicular Injury Associated With Testicular Hypoxia in Male Rats
Authors: Parsania Sara , Salehpoor Somaye , Sadrr Ameli Maryam , Abdi Morteza , Shokoohi Majid , Rahimi Mamaghani Alireza , Majdi Leila
Published: August 2024

Objectives: This study aims to comprehensively assess the therapeutic potential of clove extract in mitigating testicular damage and preserving male reproductive function under hypoxic conditions in male rats. Materials and Methods: We randomly divided 24 male rats into three groups: a hypoxia group that just received normal saline, a hypoxia + clove extract (4 mg/kg) group, and a sham operation group without treatment. After eight weeks, the serum level of oxidative stress parameters was examined, and the testicle histopathological examination, such as seminiferous tubule diameters and epithelium thickness, was assessed. Results: The serum malondialdehyde (MDA) concentration was significantly enhanced in the hypoxic group, and the levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx) declined (P<0.05). The diameters and thickness of the seminiferous tubule were diminished notably (P<0.05). Johnson’s score decreased in the hypoxic group. Treatment with clove extract also led to improvements in this parameter. Conclusions: Our study provides compelling evidence for the therapeutic potential of clove extract in mitigating testicular injury associated with varicocele-induced testicular hypoxia in male rats.
Effects of Ethanolic Extract of Walnut Leaf on Albumin and Hemoglobin Glycosylation In Vitro
Authors: Heshmati Anaraki Yasaman , Shahanipour Kahin , Monajemi Ramesh , Rezvani Sichani Ziba , Rezvani Sichani Adel
Published: August 2024

Background: One of the complications of diabetes mellitus is the glycosylation of various proteins in the body. The purpose of this study was to explore the glycosylation reaction of albumin (Alb) and hemoglobin (Hb) in the presence of varying concentrations of the hydroalcoholic extract derived from dried walnut leaves. Materials and Methods: The plants were gathered and then underwent extraction by employing the maceration technique. Next, 1 mL of the Alb solution, with a concentration of 50 mg/mL, and 1 mL of the Hb solution, with a concentration of 50 mg/mL, were separately exposed to various concentrations of the walnut leaf hydroalcoholic extract (0.1, 0.25, 0.5, 1, and 0 mg/ mL). Additionally, 1 mL of the glucose solution (30 mg/mL for Alb and 20 mg/mL for Hb) was added to each, along with 0.5 mL of phosphate buffer (pH=7.4, concentration of 0.01 M). This mixture was left for 72 hours, and the absorbance of the final solution was measured at 443 nm. Results: According to the results, the most significant inhibition of Alb glycosylation was observed in the presence of the hydroalcoholic extract from walnut leaves at a concentration of 25% µg/ mL. Moreover, the highest percentage of inhibition of glycosylated Hb was found in the presence of 5% µg/mL of the hydroalcoholic extract from dried walnut leaves. Conclusion: The hydroalcoholic extract from dried walnut leaves was observed to moderately reduce the glycosylation of both Alb and Hb.
Pregnancy in Non-communicating Rudimentary Horn
Authors: Kashani Ladan , Khezri Atefeh , Seifollahi Akram , Gharibi Zahra
Published: August 2024

Background: Pregnancy in the rudimentary horn of the unicornuate uterus is highly rare. Its incidence is 1 in 75000-150000 pregnancies. It is difficult to diagnose the rudimentary horn of the unicornuate uterus before the rupture of an ectopic pregnancy. Case Presentation: The current study reports the case of a 35-year-old Iranian mother with a natural contraceptive method. The mother was a primigravida woman at the gestational age of 7 weeks, based on her last period. She complained of abdominal pain in the right and lower abdomen and had a positive pregnancy test with a beta-human chorionic gonadotropin beta-human chorionic gonadotropin (beta-hCG) titration of 38982 on May 17, 2021. The ultrasound report on May 17, 2021, showed a right adnexal mass with a size of 32*32*31 and a fetal pole, and yolk sac. A fetal heart of six weeks and one day in favor of ectopic pregnancy was detected. and its endometrial thickness was 12 mm. There were no abdominal or pelvic-free fluids. Thus, after being diagnosed with an ectopic pregnancy that included a heart, the patient was transferred to the operating room for laparoscopy. During laparoscopy, we found that the pregnancy was in the rudimentary horn of the unicornuate uterus. The rudimentary horn was resected, and the salpingectomy of the right side was performed for the patient. The samples were then transferred to the laboratory for pathological analysis. Conclusion: We should increase awareness about pregnancies that occur in this uterine abnormality so that there is a high suspicion index for faster diagnosis before the rupture of ectopic pregnancy and worse events can be prevented accordingly.
Investigating the Association Between Smoking and Death in Patients With COVID-19 in Iran: A Meta-analysis Study
Authors: Sasani Elahe , Fendereski Afsaneh , Rafat Zahra , Davoodian Parivash , Kamali Marzieh , Bagheri-Josheghani Sareh , Karmostaji Afsaneh
Published: August 2024

Background: With reducing the immune function of the pulmonary, smoking is considered a risk factor for contracting other infections with more severe outcomes. The present study investigates a meta-analysis of the association between smoking and the progression of COVID-19 infection in Iran. Materials and Methods: The online databases of PubMed/MEDLINE and Web of Science were searched on August 23, 2022, with the following terms: (‘‘COVID-19’’ OR ‘‘SARS-CoV-2’’ OR ‘‘Coronavirus’’), AND (‘‘smoking’’ OR ‘‘smoker*’’), AND ("Iran"). In this review, we included the studies with molecular-confirmed cases of COVID-19 and the outcome of death. The Mantel-Hensel meta-analysis method with random effects was used to investigate the relationship in the data. Results: We identified 8 papers with a total of 9199 COVID-19 patients, of whom 1861(20.2%) had the outcome of death, and 1105(12%) had a history of smoking. A total of 274 patients with a history of smoking (24.7%) were dead. The meta-analysis showed a significant association between smoking and death related to COVID-19 (odds ratio=1.22, 95% confidence interval [1.03-1.44], P=0.001). Therefore, the probability of death in COVID-19 patients with a history of smoking is about 22% higher than other people. Conclusion: Smoking is a risk factor for the progression of COVID-19, with smokers having higher odds of COVID-19 progression than non-smokers.
Preparation and In Vitro Characterization of Carbamazepine-Loaded Chitosan-Coated/Uncoated PLGA and Zein Nanoparticles
Authors: Uğur Kaplan Afife Büşra , Çetin Meltem
Published: August 2024

The aim of this study is to prepare CBZ-loaded chitosan (Ch)- coated/uncoated poly(lactic-co-glycolic acid) (PLGA) and Zein (using 20 mg or 40 mg Zein) nanoparticles (CBZ-PLGA-Zein-NPs or CBZ-PLGA-Zein-Ch-NPs) and to characterize (Particle size, PDI, zeta potential, percent encapsulation efficiency (EE%), FT-IR, DSC and XRD analyzes, and in vitro release study) them in vitro. These nanoparticles were prepared using a modified emulsification-solvent evaporation method. The particle sizes of CBZ-PLGA-Zein(20)-NPs, CBZ-PLGA-Zein(40)-NPs and CBZ-PLGA-Zein(20)-Ch-NPs were found to be about 222 nm, 245 nm and 221 nm, respectively. The PDI value of all NP formulations was below 0.3. This indicates a narrow particle size distribution. The EE% values of CBZ-PLGA-Zein(20)-NPs, CBZ-PLGA-Zein(40)-NPs and CBZ-PLGA-Zein(20)-Ch-NPs were determined as about 64%, 56% and 62%, respectively. The coating of the optimum formulation (containing 20 mg Zein) with chitosan did not lead to a significant difference in the particle size and EE% value of this formulation (P>0.05). A sustained release of CBZ from all prepared NPs formulations was achieved until 48th h. In conclusion, CBZ-PLGA-Zein(20 mg or 40 mg)-NPs and CBZ-PLGA-Zein(20 mg)-Ch-NPs were successfully prepared and characterized in vitro.
ПРОФЕСІЙНА МАЙСТЕРНІСТЬ ВИКЛАДАЧА ВИЩОЇ ШКОЛИ В УМОВАХ ДІДЖІТАЛІЗАЦІЇ ОСВІТНЬОГО ПРОЦЕСУ
Authors: Кін Олена
Published: August 2024

У статті проаналізовано та висвітлено особливості процесу цифровізації вищої освіти: неузгодженість та розбалансованість діджиталізації організаційної та дидактичної складової освітнього процесу; довготривалість та послідовність процесу діджиталізації освіти; системність реалізації цифрової стратегії в академічному середовищі; орієнтація на підвищення ефективності освітнього процесу. розбудова інфраструктури вишів у відповідності до вимог цифровізації. Визначені вимоги до педагогів для ефективного та результативного використання потенціалу цифрових засобів, яке б сприяло підвищенню якості навчання: створення закладами освіти цілісного цифрового освітнього простору, який би гармонійно поєднував організаційну, комунікаційну, дидактичну складові; підвищення цифрової грамотності викладачів; модернізація процесу навчання; здатність гармонійно інтегрувати ІКТ, цифрові ресурси до освітнього середовища вишів. Доведено, що особлива увага приділяється ролі викладачу, його професійній майстерності, здатності ефективно застосовувати цифрові сервіси та ІКТ в організації та реалізації освітнього процесу. Професійна майстерність безпосередньо пов’язана й реалізується у професійної діяльності викладача й виявляється у високому рівні мистецтва організації та реалізації процесів навчання та виховання. Виходячи зі змісту і структури професійної діяльності можна виділити основні напрями реалізації професійної майстерності викладача вищої школи, зумовлені вимогами розвитку цифрової стратегій вищої освіти: стимулювання пізнавальної активності та самостійності здобувачів (використовувати сервіси й платформи для онлайн-скрайбінгу, інтелект карт, відео та аудіо ресурси); організація ефективної комунікації із здобувачами (ігрові вправи, вправа «Асоціативний кущ» які реалізовуються за допомогою цифрових застосунків); організація зворотного зв’язку, отримання об’єктивної інформації про рівень засвоєння знань, вмінь та навичок (вікторини, квести, конструктори яких розташовані на платформах Всеосвіта, Learning Apps).
Ключові слова: професійна майстерність; викладач вищої школи; цифрові сервіси; діджиталізація освітнього процесу.
ТЕОРЕТИЧНІ ТА ПРАКТИЧНІ АСПЕКТИ ПРОЄКТНОЇ ДІЯЛЬНОСТІ ПЕДАГОГІВ ЗАКЛАДІВ ФАХОВОЇ ПЕРЕДВИЩОЇ ОСВІТИ
Authors: Кошіль Оксана
Published: August 2024

У статті проаналізовано проблему проєктної діяльності педагогів закладів фахової передвищої освіти як чинника професійного розвитку та підвищення якості освіти. Зважаючи на теоретичний аналіз наукових публікацій, уточнено поняття «педагогічне проєктування». Здійснено теоретичний аналіз поняття «проєктна діяльність», наведено основні підходи до її тлумачення у наукових публікаціях та відображено власне визначення окресленої проблеми. Зазначено, що проєктування в освітній галузі − це створення як широкомасштабних проєктів, спрямованих на вирішення актуальних проблем в галузі освіти, так і проєктів модернізації освітнього процесу конкретного закладу освіти. Обґрунтовано доцільність впровадження проєктного навчання в закладі освіти. Доведено, що проєктна діяльність зумовлює становлення та розвиток особистості в умовах освітнього закладу. Обґрунтовано необхідність формування проєктної компетентності педагога закладу фахової передвищої освіти, яку визначено через комплекс специфічних навичок і умінь. Окреслено шляхи формування проєктної компетентності у викладачів закладів фахової передвищої освіти. Виокремлено закономірності проєктної діяльності педагога закладу фахової передвищої освіти, визначено її ключові аспекти, розглянуто умови, які забезпечують успішність такої діяльності. Охарактеризовано структурні компоненти проєктної діяльності педагога закладу фахової передвищої освіти в контексті його професійної діяльності.
Ключові слова: проєктування; педагогічне проєктування; проєктне навчання; проєктна діяльність; професійний розвиток; проєктна компетентність.
СУТНІСТЬ І СТРУКТУРА САМООСВІТНЬОЇ КОМПЕТЕНТНОСТІ МАЙБУТНІХ БАКАЛАВРІВ МАШИНОБУДІВНИХ СПЕЦІАЛЬНОСТЕЙ
Authors: Кравцова Наталія
Published: August 2024

У статті обґрунтовано актуальність розвитку самоосвітньої компетентності майбутніх бакалаврів машинобудівних спеціальностей. Проаналізовано визначення дефініції «самоосвітня компетентність», особливості професійної діяльності майбутніх інженерів-машинобудівників. Підкреслено сучасні тенденції науково-технічного прогресу в машинобудівній галузі, які вимагають від фахівців сформованої самоосвітньої компетентності та їх готовності до безперервного навчання. Акцентовано увагу на ролі самоосвітньої діяльності студентів за умов онлайн навчання. Підкреслено, що підчас онлайн навчання збільшується навантаження для самостійної діяльності здобувачів освіти, що потребує формування навичок самоосвітньої діяльності. Презентовано авторський варіант визначення самоосвітньої компетентності майбутніх бакалаврів машинобудівних спеціальностей. Висвітлено результат аналізу наукових підходів щодо структурних складових самоосвітньої діяльності. Наголошено, що самоосвітня компетентність реалізується саме в самоосвітній діяльності. На підставі детального аналізу наукових концепцій щодо структури діяльності та компонентів навчальної діяльності запропоновано власну структуру самоосвітньої компетентності майбутніх бакалаврів машинобудівних спеціальностей, яка містить такі компоненти: мотиваційний, організаційно-цільовий, операційно-діяльнісний, контрольно-рефлексивний. Охарактеризовано їх основні функції та завдання. Доведено, що усі запропоновані компоненти самоосвітньої компетентності майбутніх бакалаврів машинобудівних спеціальностей взаємообумовлені, утворюють цілісну структуру і потребують цілеспрямованого формування в їх єдності та послідовності. Наголошено, що у сучасному світі тільки сформовані навички самоосвітньої компетентності можуть забезпечити професіоналізм та конкурентоспроможність майбутніх фахівців на ринку праці.
Ключові слова: самоосвітня діяльність; самоосвітня компетентність; компонент; майбутні бакалаври машинобудівних спеціальностей; освіта впродовж життя.
СКЛАДОВІ ІМІДЖУ ПЕДАГОГІЧНИХ ПРАЦІВНИКІВ ЗАКЛАДІВ ВИЩОЇ ОСВІТИ КНР
Authors: Васильєва Світлана , Ді У
Published: August 2024

В оглядовій статті на основі аналізу наукових досліджень охарактеризовано складові особистісного іміджу педагогічних працівників у закладах вищої освіти Китайської Народної Республіки. Авторами прийнято позицію, що створення позитивного професійного іміджу допомагає педагогічним працівникам забезпечити успішну кар'єру, підвищити авторитет університету та впливати на його освітнє середовище. Зазначено, що імідж китайські вчені тлумачать як комплексне уявлення про зовнішній вигляд, поведінку й характер педагогічного працівника, що складається у свідомості здобувачів, батьків, колег і суспільстві в цілому. У результаті здійсненого дослідження встановлено, що науковці КНР виокремлюють різні види іміджу: зовнішній імідж, мовний імідж, імідж поведінки, імідж викладання; толерантність, активне слухання, комунікативні вміння, знання тощо. На основі узагальнення складових іміджу було виокремлено такі: педагогічна етика (дотримання законодавства, відповідальне ставлення до праці, внутрішній світ особистості, самооцінка, самоконтроль, співпраця з колегами, емпатія, терпіння, активне слухання), знання (знання з предмету, методики викладання, практичний досвід застосування знань, знання зі створення позитивної атмосфери, знання з активізації пізнавальної діяльності, знання з основ науково-дослідної діяльності (знання наукової грамотності, науково-технічні знання), освітня мудрість, знання з інноваційної діяльності, систематичні знання (педагогічні, психологічні, фізіологічні знання про розвиток особистості), педагогічний імідж (зовнішній вигляд, комунікативні компетентності, поведінковий імідж, імідж викладання), професійні здібності (навички: інтерпретації, реконструкції, комунікації, мови тіла, діагностики, наукової грамотності). Порівняльний аналіз досвіду формування іміджу викладачів закладів вищої освіти в Україні та Китаї виокремлено як перспективний напрям подальших наукових досліджень.
Ключові слова: імідж; складові іміджу; педагогічні працівники; Китайська Народна Республіка.
ОСОБЛИВОСТІ РОЗВИТКУ ПРОФЕСІЙНО-ЦИФРОВОЇ КОМПЕТЕНТНОСТІ ВЧИТЕЛЯ У НОРВЕГІЇ
Authors: Котун Кирил
Published: August 2024

В оглядовій статті обґрунтовано актуальність і важливість цифрової освіти в контексті норвезької педагогічної системи. У статті проаналізовано сучасні дослідження, що стосуються ролі цифрових технологій у підготовці та професійному розвитку вчителів. Автор акцентує увагу на динамічній природі професійно-цифрової компетентності, яка вимагає від освітніх програм постійного оновлення та адаптації до сучасних вимог. Огляд наукової та документальної літератури підкреслює необхідність інтеграції цифрових ресурсів у навчальний процес, з метою ефективного використання цих технологій для підвищення якості освіти. Подається детальний опис трактування норвезькими вченими-педагогами поняття «професійно-цифрова компетентність вчителя», яка включає в себе знання, уміння та навички, необхідні для використання цифрових технологій у педагогічній діяльності. Аналіз джерел показує, що хоча багато уваги приділяється розвитку цифрових навичок у педагогічній освіті, існують прогалини у дослідженнях, що стосуються впливу цих компетенцій на педагогічну практику. У статті вказано на необхідність подальших досліджень для вивчення аспектів норвезької освітньої системи щодо реалізації професійно-цифрової компетентності вчителя та її подальшого розвитку, що дозволить визначити ефективні стратегії інтеграції цифрової компетентності у педагогічну освіту України. Виокремлено вагомі проєкти в галузі цифровізації (PILOT, PLUTO, DigGLU та GrunnDIG). Окреслено історичний огляд цифрової компетентності вчителів у норвезькому контексті. Цей науково-літературний огляд особливостей розвитку професійно-цифрової компетентності вчителя Норвегії є важливим внеском у розуміння ролі цифрової компетентності в сучасній освіті, надаючи основу для розробки політик і програм, спрямованих на підготовку вчителів, здатних використовувати цифрові технології в освітньому процесі.
Ключові слова: професійно-цифрова компетентність; вчителі; здобувачі освіти; педагогічна підготовка; професійний розвиток; Норвегія.