bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of COVID-19 Outbreak and Incidence on the Health-Related Behaviors and Depression of Gyeongnam Residents in Republic of Korea
Authors: Seo Young-Mi , Park Ki-Soo
Published: September 2023

Background and Objectives: This study aimed to investigate whether the occurrence of COVID-19 brought about changes in the health behaviors and depression levels of residents in Gyeongnam in Republic of Korea, and whether the prevalence of COVID-19 was related to differences in health behaviors and depression levels among different regions. Materials and Methods: The researchers utilized raw data from the 2019–2020 Community Health Survey in Gyeongnam and conducted analyses using SPSS 25.0. The study included a total of 35,880 participants from 18 cities and counties in the Gyeongnam region (17,942 participants in 2019 and 17,938 participants in 2020). Results: The results of the comparative analysis between pre- and post-COVID-19 occurrence showed that, after the occurrence of COVID-19, the smoking cessation rate and monthly alcohol consumption rate among current smokers decreased, while the high-risk drinking rate increased. The rate of physical activity (walking) increased, but the prevalence of depression experiences and depressive symptoms also increased. Furthermore, the comparative analysis between areas with a higher number of COVID-19 cases and those with a lower number of cases revealed that areas with a higher number of cases had higher monthly alcohol consumption rates, as well as a higher prevalence of depression experiences and depressive symptoms. Conclusions: Considering that the occurrence and severity of COVID-19 had significant impacts on the health behaviors and depression levels of residents in Gyeongnam, this highlights the need for active intervention and management by the national and local governments in response to the occurrence and management of infectious diseases, including COVID-19, to address the health status and health behaviors of the local population.
Implicit Motor Learning Strategies Benefit Dual-Task Performance in Patients with Stroke
Authors: Arikawa Eito , Kubota Masatomo , Haraguchi Tomoko , Takata Masachika , Natsugoe Shoji
Published: September 2023

Background and Objectives: In stroke rehabilitation, the use of either implicit or explicit learning as a motor learning approach during dual tasks is common, but it is unclear which strategy is more beneficial. This study aims to determine the benefits of implicit versus explicit motor learning approaches in patients with stroke. Materials and Methods: Seventeen patients with stroke and 21 control participants were included. Motor learning was evaluated using the Serial Reaction Time Task (SRTT) in the context of dual-task conditions. The SRTT was conducted on two separate days: one day for implicit learning conditions and the other day for explicit learning conditions. Under the explicit learning conditions, a task rule was given to the participants before they started the task, but not under the implicit learning conditions. Learning scores were calculated for both implicit and explicit learning, and these scores were then compared within groups for patients with stroke and controls. We calculated the difference in learning scores between implicit and explicit learning and conducted a correlation analysis with the Trail Making Test (TMT) Parts A and B. Results: Learning scores on the SRTT were not different between implicit and explicit learning in controls but were significantly greater in patients with stroke for implicit learning than for explicit learning. The difference in learning scores between implicit and explicit learning in patients with stroke was correlated with TMT-A and showed a correlation trend with TMT-B. Conclusions: Implicit learning approaches may be effective in the acquisition of motor skills with dual-task demands in post-stroke patients with deficits in attention and working memory.
Therapies and Challenges in the Post-Stroke Aphasia Rehabilitation Arena: Current and Future Prospects
Authors: Georgiou Anastasios M. , Kambanaros Maria
Published: September 2023

Aphasia is a serious consequence of stroke that results in a breakdown in communication. The course of aphasia recovery differs between afflicted individuals, and responsiveness to treatment cannot be predicted. Aphasiologists continue to investigate numerous behavioral treatment protocols that have shifted their focus to complimentary rehabilitation strategies. The aim of this study is threefold. First, to summarize the different categories of aphasia interventions post-stroke, considering their respective protocols, and present available evidence on the effectiveness of those protocols. Second, to document the challenges regarding the prediction of aphasia treatment response post-stroke in individual patients. Third, to report the challenges faced by researchers in recruiting people with aphasia (PWA) for treatment studies, and provide recommendations on how to increase participant recruitment and retention. This study provides up-to-date information on (i) effective therapies and aphasia recovery processes, and (ii) research recruitment hurdles together with potential strategies for overcoming them.
An Overview of Robotic Colorectal Surgery Adoption and Training in Brazil
Authors: Alves Martins Bruno Augusto , Filho Oswaldo de Moraes , Ghezzi Tiago Leal , Melani Armando Geraldo Franchini , Romagnolo Luis Gustavo Capochin , Moreira Júnior Hélio , de Almeida João Pedro Pereira , Araújo Sérgio Eduardo Alonso , de Sousa João Batista , de Almeida Romulo Medeiros
Published: September 2023

Background and Objectives: Robotic surgical systems have rapidly become integrated into colorectal surgery practice in recent years, particularly for rectal resections, where the advantages of robotic platforms over conventional laparoscopy are more pronounced. However, as with any technological advancement, the initial high costs can be a limiting factor, leading to unequal health service access, especially in middle- and lower-income countries. Materials and Method: A narrative review was conducted with the objective of providing an overview of the escalating adoption, current training programmes, and certification process of robotic colorectal surgery in Brazil. Results: Brazil has witnessed a rapid increase in robotic platforms in recent years. Currently, there are 106 robotic systems installed nationwide. However, approximately 60% of the medical facilities which adopted robotic platforms are in the Southeast region, which is both the most populous and economically prosperous in the country. The Brazilian Society of Coloproctology recently established clear rules for the training programme and certification of colorectal surgeons in robotic surgery. The key components of the training encompass theoretical content, virtual robotic simulation, observation, assistance, and supervised procedures in colorectal surgery. Although the training parameters are well established, no colorectal surgery residency programme in Brazil has yet integrated the teaching and training of robotic surgery into its curriculum. Thus far, the training process has been led by private institutions and the industry. Conclusion: Despite the fast spread of robotic platforms across Brazil, several challenges still need to be addressed to democratise training and promote the widespread use of these platforms. It is crucial to tackle these obstacles to achieve greater integration of robotic technology in colorectal surgery throughout the country.
Simultaneous Administration of Hyperbaric Oxygen Therapy and Antioxidant Supplementation with Filipendula ulmaria Extract in the Treatment of Thermal Skin Injuries Alters Nociceptive Signalling and Wound Healing
Authors: Krstic Milos , Jovicic Nemanja , Selakovic Dragica , Krstic Bojana , Arsenijevic Natalija , Vasiljevic Milica , Milanovic Pavle , Milanovic Jovana , Milovanovic Dragan , Simic Marko , Katanic Stankovic Jelena , Rosic Gvozden
Published: September 2023

Background and Objectives: Thermal skin injuries are a prevalent cause of skin damage, potentially leading to severe morbidity and significant mortality. In this study, we intended to estimate the effects of HBO (hyperbaric oxygen treatment) and antioxidant supplementation with Filipendula ulmaria extract, individually and simultaneously, in the treatment of thermal skin injuries. Materials and Methods: As a thermal skin injury experimental model, we used two-month-old male Wistar albino rats. Thermal injuries were made with a solid aluminium bar at a constant temperature of 75 °C for 15 s. Hyperbaric oxygen treatment was performed in a specially constructed hyperbaric chamber for rats (HYB-C 300) for seven consecutive days (100% O2 at 2.5 ATA for 60 min). Antioxidant supplementation was performed with oral administration of Filipendula ulmaria extract dissolved in tap water to reach a final concentration of 100 mg/kg b.w. for seven consecutive days. Results: Simultaneous administration of hyperbaric oxygen therapy and antioxidant supplementation with Filipendula ulmaria extract significantly ameliorated the macroscopic and histopathological characteristics of the wound area and healing. Also, this therapeutic approach decreased the local expression of genes for proinflammatory mediators and increased the expression of the μ-opioid receptor and the MT1 and MT2 receptors in the wound area and spinal cord, with a consequent increase in reaction times in behavioural testing. Conclusions: In conclusion, the presented results of our study allow evidence for the advantages of the simultaneous employment of HBO and antioxidant supplementation in the treatment of thermal skin injuries, with special reference to the attenuation of painful sensations accompanied by this type of trauma.
Dose Optimization Using a Deep Learning Tool in Various CT Protocols for Urolithiasis: A Physical Human Phantom Study
Authors: Shim Jae Hun , Choi Se Young , Chang In Ho , Park Sung Bin
Published: September 2023

Background and Objectives: We attempted to determine the optimal radiation dose to maintain image quality using a deep learning application in a physical human phantom. Materials and Methods: Three 5 × 5 × 5 mm3 uric acid stones were placed in a physical human phantom in various locations. Three tube voltages (120, 100, and 80 kV) and four current–time products (100, 70, 30, and 15 mAs) were implemented in 12 scans. Each scan was reconstructed with filtered back projection (FBP), statistical iterative reconstruction (IR, iDose), and knowledge-based iterative model reconstruction (IMR). By applying deep learning to each image, we took 12 more scans. Objective image assessments were calculated using the standard deviation of the Hounsfield unit (HU). Subjective image assessments were performed by one radiologist and one urologist. Two radiologists assessed the subjective assessment and found the stone under the absence of information. We used this data to calculate the diagnostic accuracy. Results: Objective image noise was decreased after applying a deep learning tool in all images of FBP, iDose, and IMR. There was no statistical difference between iDose and deep learning-applied FBP images (10.1 ± 11.9, 9.5 ± 18.5 HU, p = 0.583, respectively). At a 100 kV–30 mAs setting, deep learning-applied FBP obtained a similar objective noise in approximately one third of the radiation doses compared to FBP. In radiation doses with settings lower than 100 kV–30 mAs, the subject image assessment (image quality, confidence level, and noise) showed deteriorated scores. Diagnostic accuracy was increased when the deep learning setting was lower than 100 kV–30 mAs, except for at 80 kV–15 mAs. Conclusions: At the setting of 100 kV–30 mAs or higher, deep learning-applied FBP did not differ in image quality compared to IR. At the setting of 100 kV–30 mAs, the radiation dose can decrease by about one third while maintaining objective noise.
Reconstruction of Moderately and Severely Atrophic Scalp—A Multicentric Experience in Surgical Treatment of Patients Irradiated for Tinea Capitis in Childhood and Surgical Algorithm
Authors: Nikolić Živanović Maja , Jurišić Milana , Marinković Milana , Grujičić Danica , Stanimirović Aleksandar , Šćepanović Vuk , Milićević Mihailo , Jovićević Nikola , Videnović Goran , Pavlović Vedrana , Bogunović Stojičić Sanda , Jovanović Milan , Jeremić Jelena , Jović Marko , Ilić Rosanda , Stojičić Milan
Published: September 2023

Background and Objectives: Before the introduction of griseofluvin, the use of X-ray radiation was the treatment of choice for tinea capitis. More than half a century later various types of tumors have been found to be associated with childhood irradiation due to tinea capitis, most commonly cancers of the head and neck, as well as brain tumors. The often unusually aggressive and recurrent nature of these tumors necessitates the need for repeated surgeries, while the atrophic skin with an impaired vascular supply due to radiation often poses an additional challenge for defect reconstruction. We present our experience in the surgical treatment of such patients. Materials and Methods: This is a retrospective cohort study. In this study, 37 patients treated for acquired defects of the scalp with a history of irradiation therapy due to tinea capitis in childhood were included in this study, 24 male and 13 female patients. The mean age at the first appointment was 60.6 ± 7.8, with the youngest included patient being 46 and the oldest being 75 years old. Patients’ characteristics, surgical treatment, and complications were analyzed and a reconstructive algorithm was developed. Results: Local flaps were used for reconstruction in 34 patients, direct sutures were used in 10 patients and 20 patients received split-thickness skin grafts for coverage of both primary and secondary defects for reconstruction of flap donor sites. One regional flap and one dermal substitute covered by an autologous skin graft were also used for reconstruction. Complications occurred in 43.2% of patients and were significantly associated with the presence of comorbidities (p = 0.001), aseptic bone necrosis (p = 0.001), as well as skin atrophy in frontal, occipital, and parietal region (p = 0.001, p = 0.042 and p = 0.001, respectively). A significant correlation between major complications and moderate skin atrophy was found only in the parietal region (p = 0.026). Conclusions: Unfortunately, many protocols developed for scalp reconstruction are not applicable in the setting of severe or diffuse scalp skin atrophy associated with high tumor recurrence rate and radiation-induced vascular impairment, such as in tinea capitis patients in Serbia. An algorithm has been developed based on the authors’ experience in managing these patients.
Advancements in Standardizing Radiological Reports: A Comprehensive Review
Authors: Pesapane Filippo , Tantrige Priyan , De Marco Paolo , Carriero Serena , Zugni Fabio , Nicosia Luca , Bozzini Anna Carla , Rotili Anna , Latronico Antuono , Abbate Francesca , Origgi Daniela , Santicchia Sonia , Petralia Giuseppe , Carrafiello Gianpaolo , Cassano Enrico
Published: September 2023

Standardized radiological reports stimulate debate in the medical imaging field. This review paper explores the advantages and challenges of standardized reporting. Standardized reporting can offer improved clarity and efficiency of communication among radiologists and the multidisciplinary team. However, challenges include limited flexibility, initially increased time and effort, and potential user experience issues. The efforts toward standardization are examined, encompassing the establishment of reporting templates, use of common imaging lexicons, and integration of clinical decision support tools. Recent technological advancements, including multimedia-enhanced reporting and AI-driven solutions, are discussed for their potential to improve the standardization process. Organizations such as the ACR, ESUR, RSNA, and ESR have developed standardized reporting systems, templates, and platforms to promote uniformity and collaboration. However, challenges remain in terms of workflow adjustments, language and format variability, and the need for validation. The review concludes by presenting a set of ten essential rules for creating standardized radiology reports, emphasizing clarity, consistency, and adherence to structured formats.
Casting and Forming of Light Alloys
Authors: Jiang Wenming , Xu Yuancai
Published: September 2023

With the rapid development of aviation, aerospace, navigation, automotive, electronics and other fields, the demand for light alloys components is increasing, and the performance requirements are becoming higher and higher, especially for large complex light alloys components [...]
Influence of Aluminum Content on the Microstructure, Mechanical Properties, and Hot Deformation Behavior of Mg-Al-Zn Alloys
Authors: Moses Marie , Ullmann Madlen , Prahl Ulrich
Published: September 2023

This study compares AZ91 with AZ31 to investigate the influence of a higher Al content on the resulting microstructure, mechanical properties, and hot deformation behavior. While AZ31 exhibits a globular structure after casting, AZ91 shows a fully developed dendritic structure due to the promotion of dendrites. A heat treatment helped to homogenize AZ31, dissolved a large part of the Mg-Al precipitations in AZ91, and formed globular grains in AZ91. Due to the impact of Al on constitutional supercooling, AZ91 exhibits smaller grains than AZ31. Because of the strengthening of the solid solution, AZ91 also exhibits higher strength and hardness compared to AZ31. Cylindric compression tests of the heat-treated samples were conducted at different temperatures (300–400 °C) and strain rates (0.1 × 10 s−1). The main dynamic recrystallization (DRX) mechanisms in AZ31 and AZ91 are twinning-induced DRX and discontinuous DRX. It was detected that Mg17Al12 precipitates at the grain boundaries in AZ91, which influences the grain size through pinning. Similar results could be conducted in rolling trials. Although both alloys have similar grain sizes after rolling, AZ91 exhibits higher strengths, while AZ31 shows higher ductility. This can be explained by the solid solution strengthening in AZ91 and less brittle Mg17Al12 precipitations in AZ31.
Improving the Microstructure and Mechanical Properties of Laser-Welded Al–Si-Coated 22MnB5/Galvanized Steel Joints Added by Nickel
Authors: Zhang Youping , Qin Youqiong , Zhao Feng , Liang Min
Published: September 2023

To weaken the harm of Al–Si coating and increase the strength of welded joints, variable thicknesses of Ni foil (Ni, an austenitic formation element) were added to the lap laser welding Al–Si-coated 22MnB5 hot stamping steel/galvanized steel joints. The joints’ weld appearance, microstructure, and mechanical properties were explored. The weld altered from an X shape to a Y shape with an increased thickness of Ni foil. During welding, Al–Si coating was melted and diluted into the welding pool, forming δ-ferrite (a rich-Al phase with low toughness and strength) in the fusion zone (FZ) and fusion boundary (FB). This phase deteriorated the strength of the joints. After adding Ni, the amount and size of the δ-ferrite phase decreased. With a significant thickness of Ni foil, δ-ferrite disappeared. However, a new phase (fresh martensite (FM), which formed at low temperature and contained rich Ni) probably formed, except PM (previous martensite (PM), which formed at high temperature and contained little Ni or no Ni). The heat-affected zone (HAZ) on the side of 22MnB5 comprised a coarse martensite zone, refined martensite zone, martensite + ferrite zone, and tempered martensite zone from the FZ to the basic material. HAZ on the side of galvanized steel mainly contained ferrite and pearlite. After adding the Ni foil, the strength of the joint was greater than that without Ni. The maximum strength of the joint can be up to 679 MPa because of the disappearance of δ-ferrite. Meanwhile, the toughness of the joint increased. The fracture mode was from three mixed fractures (cleavage, quasi-cleavage, and dimple) to one fracture (dimple).
Analysis of the Mechanical and Microstructural Fluctuations of High-Strength Steels and Their Effect on Bending Angle
Authors: Muñiz Laura , Trinidad Javier , Galdos Lander
Published: September 2023

The quality and complexity demands of manufactured parts in sectors such as automotive and aeronautics lead to narrower process windows. This affects the repeatability and stability of the process, where material properties and process variations have a major impact. In bending processes, the bending angle is affected by variability in mechanical and microstructural properties, especially in high-strength materials. To address this, mechanical and microstructural characterization is crucial. This study conducted mechanical and microstructural characterization on five high-strength steels from different suppliers: three DP980 and two CP980. These materials are currently used by an industrial company in the automotive sector to manufacture a real product by means of U-bending, where a real issue of variability exists. Tensile tests were performed to quantify mechanical fluctuations. Microstructural analysis was also performed to determine the grain size and volume fractions of martensite and ferrite in the case of DP980, and ferrite, bainite, and retained austenite in the case of CP980. The largest variations were found for the hardening exponent, mean grain size, and elongation. To analyze their variability in an industrial process, U-bending tests were carried out using the five materials and the bending angle after the springback was measured. A total of 250 pieces were bent for the different materials and press strokes. Variations up to 1.25° in bending angle were found between the five batches for the same press stroke. A quantitative correlation analysis was performed to estimate the influence of the different parameters on the bending angle, where sheet thickness and tensile strength were shown to be two of the most influential parameters. Knowing this influence based on the variability of the properties, a control approach can be developed to reduce defects.
Influence of Surface Sputtering during High-Intensity, Hot Ion Implantation on Deep Alloying of Martensitic Stainless Steel
Authors: Ryabchikov Alexander , Korneva Olga , Ivanova Anna , Dektyarev Sergey , Vakhrushev Dimitriy , Gurulev Alexander
Published: September 2023

This article is devoted to the study of the effect of ion sputtering on the alloy surface, using the example of martensitic stainless steel AISI 420 with ultrahigh-dose, high-intensity nitrogen ion implantation on the efficiency of accumulation and transformation of the depth distribution of dopants. Some patterns of change in the depth of ion doping depending on the target temperature in the range from 400 to 650 °C, current density from 55 to 250 mA/cm2, and ion fluence up to 4.5 × 1021 ion/cm2 are studied. It has been experimentally established that a decrease in the ion sputtering coefficient of the surface due to a decrease in the energy of nitrogen ions from 1600 to 350 eV, while maintaining the ion current density, ion irradiation fluence and temperature mode of target irradiation increases the ion-doped layer depth by more than three times from 25 μm to 65 µm. The efficient diffusion coefficient at an ion doping depth of 65 μm is many times greater than the data obtained when stainless steel is nitrided with an ion flux with a current density of about 2 mA/cm2.
Contact Fatigue Behavior Evolution of 18CrNiMo7-6 Gear Steel Based on Surface Integrity
Authors: Wu Luji , Lv Yongxin , Zhang Yalong , Li Anhu , Ji Vincent
Published: September 2023

In this work, the surface integrity (surface morphology, microstructure, microhardness, residual stress) of contact fatigue (CF) samples with different numbers of running cycles was comprehensively studied. Based on typical working conditions, a fatigue life evaluation method was proposed based on the evolution law of surface integrity. The CF with different numbers of running cycles revealed that the average grain size decreased with the increase in the number of running cycles, and the surface microhardness, residual stress and surface roughness Ra increased first and then decreased. In addition, the relationships between different surface integrity parameters and fatigue life were plotted. Moreover, based on the fatigue life profiles, the running state and remaining life of gear samples can be evaluated.
Comparison of Metabolites and Main Nutritional Components between Uncooked and Cooked Purple Rice
Authors: Gu Wenfei , Peng Yuehong , Wang Ruizhi , Wang Runnan , Wu Han , Zhu Jinyan , Ni Xinhua , Xiong Qiangqiang
Published: September 2023

Cooking can lead to varying degrees of nutrient loss in purple rice. For this investigation, two varieties of purple rice (YZN1 and YZ6) were chosen as the focal points to explore the metabolites associated with rice nutrition post cooking using nontargeted and targeted metabolomics techniques. The results showed that after cooking the two purple rice varieties, the contents of the flavonoids; OPC; TP; total antioxidant capacity; and K, Na, Fe, Mn, Zn, Cu, Ca, and Mg significantly decreased. Compared with YZN1U (YZN1 uncooked), the amino acid and mineral element contents in YZN1C (YZN1 cooked) decreased to varying degrees. After cooking YZ6, the contents of seven amino acids significantly decreased. Following the preparation of purple rice, the metabolites primarily engaged in the pathways of flavonoid synthesis and flavone and flavonol synthesis. Flavonoids, total antioxidant capacity, mineral elements, and amino acids showed a strong correlation with delphinidin and luteolin. The ROC analysis demonstrated that the value of the area under the curve for delphinidin and luteolin was 1 when comparing YZ6C (YZ6 cooked) and YZ6U (YZ6 uncooked), as well as YZN1C and YZN1U. Delphinidin and luteolin can be used as potential biomarkers of nutrient loss after cooking purple rice. This study holds significant implications for the balanced nutrition and healthy development of human dietary grains.
Metabolomic Signatures Associated with Radiation-Induced Lung Injury by Correlating Lung Tissue to Plasma in a Rat Model
Authors: Gu Liming , Wang Wenli , Gu Yifeng , Cao Jianping , Wang Chang
Published: September 2023

The lung has raised significant concerns because of its radiosensitivity. Radiation-induced lung injury (RILI) has a serious impact on the quality of patients’ lives and limits the effect of radiotherapy on chest tumors. In clinical practice, effective drug intervention for RILI remains to be fully elucidated. Therefore, an in-depth understanding of the biological characteristics is essential to reveal the mechanisms underlying the complex biological processes and discover novel therapeutic targets in RILI. In this study, Wistar rats received 0, 10, 20 or 35 Gy whole-thorax irradiation (WTI). Lung and plasma samples were collected within 5 days post-irradiation. Then, these samples were processed using liquid chromatography–mass spectrometry (LC-MS). A panel of potential plasma metabolic markers was selected by correlation analysis between the lung tissue and plasma metabolic features, followed by the evaluation of radiation injury levels within 5 days following whole-thorax irradiation (WTI). In addition, the multiple metabolic dysregulations primarily involved amino acids, bile acids and lipid and fatty acid β-oxidation-related metabolites, implying disturbances in the urea cycle, intestinal flora metabolism and mitochondrial dysfunction. In particular, the accumulation of long-chain acylcarnitines (ACs) was observed as early as 2 d post-WTI by dynamic plasma metabolic data analysis. Our findings indicate that plasma metabolic markers have the potential for RILI assessment. These results reveal metabolic characteristics following WTI and provide new insights into therapeutic interventions for RILI.
Numerical Simulation of a Lab-on-Chip for Dielectrophoretic Separation of Circulating Tumor Cells
Authors: Alkhaiyat Abdallah M. , Badran Mohamed
Published: September 2023

Circulating tumor cells (CTCs) are cancer cells detached from tumors that enter the bloodstream with the rest of the blood cells before settling on remote organs and growing. CTCs play a major role as a target for cancer diagnosis. This study aims to propose and simulate a lab-on-chip (LOC) design that separates CTCs from white blood cells (WBCs) and blood platelets (PLTs) using low-voltage dielectrophoretic separation with high efficiency. The proposed design include two stages a passive and an active one cascaded in a compact package. Numerical simulations are performed on the COMSOL Multiphysics® software package to optimize the geometric parameters of the LOC, such as the width and length of the microchannel and the number of electrodes and their arrangements. Moreover, the effects of adjusting the applied voltage values as well as buffer inlet velocity are investigated. The proposed LOC design uses four electrodes at ±2 V to achieve 100% separation efficiency for the three cell types in simulation. The 919 µm × 440 µm LOC has a channel width of 40 µm. The inlet velocities for the blood-carrying cells and buffer are 134 and 850 µm/s, respectively. The proposed LOC can be used for the early detection of CTCs, which can be beneficial in cancer diagnosis and early treatment. In addition, it can be used in cancer prognosis, treatment monitoring and personalizing medicine.
Microfluidic Droplet-Generation Device with Flexible Walls
Authors: Yazdanparast Sajad , Rezai Pouya , Amirfazli Alidad
Published: September 2023

Controlling droplet sizes is one of the most important aspects of droplet generators used in biomedical research, drug discovery, high-throughput screening, and emulsion manufacturing applications. This is usually achieved by using multiple devices that are restricted in their range of generated droplet sizes. In this paper, a co-flow microfluidic droplet-generation device with flexible walls was developed such that the width of the continuous (C)-phase channel around the dispersed (D)-phase droplet-generating needle can be adjusted on demand. This actuation mechanism allowed for the adjustment of the C-phase flow velocity, hence providing modulated viscous forces to manipulate droplet sizes in a single device. Two distinct droplet-generation regimes were observed at low D-phase Weber numbers, i.e., a dripping regime at high- and medium-channel widths and a plug regime at low-channel widths. The effect of channel width on droplet size was investigated in the dripping regime under three modes of constant C-phase flow rate, velocity, and Capillary number. Reducing the channel width at a constant C-phase flow rate had the most pronounced effect on producing smaller droplets. This effect can be attributed to the combined influences of the wall effect and increased C-phase velocity, leading to a greater impact on droplet size due to the intensified viscous force. Droplet sizes in the range of 175–913 µm were generated; this range was ~2.5 times wider than the state of the art, notably using a single microfluidic device. Lastly, an empirical model based on Buckingham’s Pi theorem was developed to predict the size of droplets based on channel width and height as well as the C-phase Capillary and Reynolds numbers.
Review of Gas Dynamic RF-Only Funnel Technique for Low-Energy and High-Quality Ion Beam Extraction into a Vacuum
Authors: Varentsov Victor
Published: September 2023

This paper reviews the development and present status of a novel gas dynamic RF-only funnel technique for low-energy ion beam extraction into vacuum. This simple and original technique allows for the production of high-quality continuous and pulsed ion beams in a wide range of masses, which have a very small transverse and longitudinal emittance.
Bioinspiration and Biomimetic Art in Robotic Grippers
Authors: Nguyen Van Pho , Dhyan Sunil Bohra , Mai Vu , Han Boon Siew , Chow Wai Tuck
Published: September 2023

The autonomous manipulation of objects by robotic grippers has made significant strides in enhancing both human daily life and various industries. Within a brief span, a multitude of research endeavours and gripper designs have emerged, drawing inspiration primarily from biological mechanisms. It is within this context that our study takes centre stage, with the aim of conducting a meticulous review of bioinspired grippers. This exploration involved a nuanced classification framework encompassing a range of parameters, including operating principles, material compositions, actuation methods, design intricacies, fabrication techniques, and the multifaceted applications into which these grippers seamlessly integrate. Our comprehensive investigation unveiled gripper designs that brim with a depth of intricacy, rendering them indispensable across a spectrum of real-world scenarios. These bioinspired grippers with a predominant emphasis on animal-inspired solutions have become pivotal tools that not only mirror nature’s genius but also significantly enrich various domains through their versatility.
Thin Films of Chlorinated Vanadyl Phthalocyanines as Active Layers of Chemiresistive Sensors for the Detection of Ammonia
Authors: Klyamer Darya , Sukhikh Alexandr , Bonegardt Dmitry , Krasnov Pavel , Popovetskiy Pavel , Basova Tamara
Published: September 2023

Halogenated metal phthalocyanines are promising materials for the manufacture of active layers of chemiresistive sensors for the detection of various gases. Despite the high interest in such sensors, there are few systematic studies of the position of halogen substituents in phthalocyanine macroring on the chemiresistive response of their films to gases. In this work, we prepared and studied films of novel tetrachlorosubstituted vanadyl phthalocyanine derivatives with Cl substituents in the peripheral (VOPcCl4-p) and nonperipheral (VOPcCl4-np) positions of the phthalocyanine ring as active layers of chemiresistive sensors to reveal the effect of the position of substituents on their structure and sensor response to low concentrations of NH3. It was shown that the films of VOPcCl4-p exhibited a noticeably higher sensor response to NH3 than the VOPcCl4-np ones. The limit of detection of NH3 was 0.7 ppm. The sensing layers demonstrated a reversible sensor response at room temperature with fairly low response/recovery times. It was also demonstrated that NH3 can be detected in the presence of various interfering gases (CO2 and H2) and some volatile organic vapors, as well as in a mixture of gases with a composition close to exhaled air.
A Multiband Millimeter-Wave Rectangular Dielectric Resonator Antenna with Omnidirectional Radiation Using a Planar Feed
Authors: Abdou Tarek S. , Khamas Salam K.
Published: September 2023

In this study, a millimeter-wave (mmWave) dielectric resonator antenna (DRA) with an omnidirectional pattern is presented for the first time. A key feature of the proposed design is the utilization of a planar feed network to achieve omnidirectional radiation from a rectangular DRA, which has not been reported previously in the open literature. In addition, the proposed antenna offers multiband operation with different types of radiation patterns. The degenerate TE121/TE211 modes were excited at 28.5 GHz with an overall internal electromagnetic field distribution that was similar to that of the HEM21δ mode of a cylindrical DRA. The achieved omnidirectional bandwidth and gain were 1.9% and 4.3 dBi, respectively. Moreover, broadside radiation was achieved by exciting the TE111 fundamental mode at 17.5 GHz together with the resonance of the feeding ring-slot at 23 GHz. The triple-band operation offers a highly versatile antenna that can be utilized in on-body and off-body communications. Furthermore, the proposed design was validated through measurements, demonstrating good agreement with simulations.
Tribological Characterization of Micro Ball Bearings with and without Solid-State Lubrication
Authors: Samsel Mateusz Jakub , Chańko Artur , Michałowski Marcin , Fernandez-Munoz Miguel , Diez-Jimenez Efren
Published: September 2023

The tribological characteristics of a below 1 mm micro ball bearing comprising steel disc and cages coated with thin copper and silver films were investigated. Electroplating and laser cutting were used to manufacture used elements. Friction was measured using a linear stage and an adapted version of a friction-loop method. The obtained results show an interesting relationship between the geometric properties of the micro scale thrust bearing and their performance and operational stability, which can be correlated to similar relationships observed in the macro scale. The most optimal design of the bearing showed stable operation, with the simplified rolling resistance coefficient in the range 0.002 to 0.003, independently of applied load, which was in range 150 mN to 1500 mN. The possibility of creating easily manufacturable micro ball bearings with a low rolling resistance coefficient comprised solely of cheap and sturdy elements was shown.
Super-Low Friction Electrification Achieved on Polytetrafluoroethylene Films-Based Triboelectric Nanogenerators Lubricated by Graphene-Doped Silicone Oil
Authors: Chen Junzhao , Zhao Yu , Wang Ruirui , Wang Pengfei
Published: September 2023

The novel proposal of Wang’s triboelectric nanogenerator (TENG) has inspired extensive efforts to explore energy harvesting devices from the living environment for the upcoming low-carbon society. The inevitable friction and wear problems of the tribolayer materials become one of the biggest obstacles for attaining high-performance TENGs. To achieve super-low friction electrification of the TENGs, the tribological and electrical behaviors of the sliding-mode TENGs based on polytetrafluoroethylene (PTFE) films and metallic balls under both dry friction and liquid lubrication conditions were investigated by using a customized testing platform with a ball-on-flat configuration. Most interestingly, a super-low friction coefficient of 0.008 was achieved under graphene-doped silicone oil lubrication. The corresponding wear rate of the PTFE film was drastically decreased to 8.19 × 10−5 mm3/Nm. Simultaneously, the output short-circuit current and open-circuit voltage were enhanced by 6.8 times and 3.0 times, respectively, compared to the dry friction condition. The outstanding triboelectrical performances of the PTFE film when sliding against a steel ball are attributed to the synergistic lubricating effects of the silicone oil and the graphene nanosheets. The current research provides valuable insights into achieving the macro-scale superlubricity of the TENGs in practical industrial applications.
Conversion of CH4 and Hydrogen Storage via Reactions with MgH2-12Ni
Authors: Kwak Young Jun , Song Myoung Youp , Lee Ki-Tae
Published: September 2023

The main key to the future transition to a hydrogen economy society is the development of hydrogen production and storage methods. Hydrogen energy is the energy produced via the reaction of hydrogen with oxygen, producing only water as a by-product. Hydrogen energy is considered one of the potential substitutes to overcome the growing global energy demand and global warming. A new study on CH4 conversion into hydrogen and hydrogen storage was performed using a magnesium-based alloy. MgH2-12Ni (with the composition of 88 wt% MgH2 + 12 wt% Ni) was prepared in a planetary ball mill by milling in a hydrogen atmosphere (reaction-involved milling). X-ray diffraction (XRD) analysis was performed on samples after reaction-involved milling and after reactions with CH4. The variation of adsorbed or desorbed gas over time was measured using a Sieverts’-type high-pressure apparatus. The microstructure of the powders was observed using a scanning transmission microscope (STEM) with energy-dispersive X-ray spectroscopy (EDS). The synthesized samples were also characterized using Fourier transform infrared (FT-IR) spectroscopy. The XRD pattern of MgH2-12Ni after the reaction with CH4 (12 bar pressure) at 773 K and decomposition under 1.0 bar at 773 K exhibited MgH2 and Mg2NiH4 phases. This shows that CH4 conversion took place, the hydrogen produced after CH4 conversion was then adsorbed onto the particles, and hydrides were formed during cooling to room temperature. Ni and Mg2Ni formed during heating to 773 K are believed to cause catalytic effects in CH4 conversion. The remaining CH4 after conversion is pumped out at room temperature.
A Robust Triboelectric Impact Sensor with Carbon Dioxide Precursor-Based Calcium Carbonate Layer for Slap Match Application
Authors: Kim Inkyum , Cho Hyunwoo , Kitchamsetti Narasimharao , Yun Jonghyeon , Lee Jeongmin , Park Wook , Kim Daewon
Published: September 2023

As an urgent international challenge, the sudden change in climate due to global warming needs to be addressed in the near future. This can be achieved through a reduction in fossil fuel utilization and through carbon sequestration, which reduces the concentration of CO2 in the atmosphere. In this study, a self-sustainable impact sensor is proposed through implementing a triboelectric nanogenerator with a CaCO3 contact layer fabricated via a CO2 absorption method. The triboelectric polarity of CaCO3 with the location between the polyimide and the paper and the effects of varying the crystal structure are investigated first. The impact sensing characteristics are then confirmed at various input frequencies and under applied forces. Further, the high mechanical strength and strong adherence of CaCO3 on the surface of the device are demonstrated through enhanced durability compared to the unmodified device. For the intended application, the as-fabricated sensor is used to detect the turning state of the paper Ddakji in a slap match game using a supervised learning algorithm based on a support vector machine presenting a high classification accuracy of 95.8%. The robust CaCO3-based triboelectric device can provide an eco-friendly advantage due to its self-powered characteristics for impact sensing and carbon sequestration.
Investigation of the Connection Schemes between Decks in 3D NAND Flash
Authors: Jia Jianquan , Jin Lei , You Kaikai , Zhu Anyi
Published: September 2023

Dual-deck stacking technology is an effective solution for solving the contradiction between the demand for increasing storage layers and the challenge of the deep hole etching process in 3D NAND flash. The connection scheme between decks is a key technology for the dual-deck structure. It has become one of the necessary techniques for 3D NAND flash storage density improvement. This article mainly studies the impact of connection schemes between decks on cell reliability. Based on experimental data and simulation analysis, unfavorable effects were found as the gate channeling the breakdown and data retention characteristics of the top cells in the lower deck deteriorated due to the local electric field enhancement in the connection scheme without a poly-plug. This mainly contributed to the structural change of these cells within process impact. They will suffer secondary etching during the upper deck channel etching process due to alignment issues between the upper and lower decks. In another scheme with a poly-plug connection between decks, the saturation current of the channel decreased and the current variation increased. The fundamental cause of the current anomaly is that the Poly-plug has a certain shielding effect on channel inversion and the weak inversion region becomes a bottleneck for the channel current. The increase in variation is due to the shielding effect differences in the different structures of the poly-plug. Therefore, for the connection scheme without a poly-plug, the article proposes to improve device reliability by increasing the oxide thickness between decks and setting the top cells of the lower decks to be virtual cells. For the connection scheme with a poly-plug, the plug‘s N-type doping scheme is proposed to avoid the current dropping anomaly.
Editorial for the Special Issue on Network on Chip (NoC) and Reconfigurable Systems
Authors: Zitouni Abdelkrim
Published: September 2023

In a multiprocessor System-on-Chip (SoC), efficient communication between the associated processors has to be addressed at all levels of the system design to guarantee global interconnection [...]
Thermal Fatigue Effect on the Grain Groove Profile in the Case of Diffusion in Thin Polycrystalline Films of Power Electronic Devices
Authors: Hamieh Tayssir , Ibrahim Ali , Khatir Zoubir
Published: September 2023

In a previous paper, we solved the partial differential equation of Mullins’ problem in the case of the evaporation–condensation in electronic devices and gave an exact solution relative to the geometric profile of the grain boundary grooving when materials are submitted to thermal and mechanical solicitation and fatigue effect. In this new research, new modelling of the grain groove profile was proposed and new analytical expressions of the groove profile, the derivative and the groove depth were obtained in the case of diffusion in thin polycrystalline films by the resolution of the fourth differential equation formulated by Mullins that supposed y′2≪1. The obtained analytical solution gave more accurate information on the geometric characteristics of the groove that were necessary to study the depth and the width of the groove. These new findings will open a new way to study with more accuracy the problem of the evaporation–condensation combined to the diffusion phenomenon on the material surfaces with the help of the analytical solutions.
Diagnosis and Outcomes of Fungal Co-Infections in COVID-19 Infections: A Retrospective Study
Authors: Swaney Richard , Jokomo-Nyakabau Rutendo , Nguyen Anny A. N. , Kenny Dorothy , Millner Paul G. , Selim Mohammad , Destache Christopher J. , Velagapudi Manasa
Published: September 2023

The SARS-CoV-2 pandemic has resulted in a public health emergency with unique complications such as the development of fungal co-infections. The diagnosis of fungal infections can be challenging due to confounding imaging studies and difficulty obtaining histopathology. In this retrospective study, 173 patients with COVID-19 receiving antifungal therapy due to concern for fungal co-infection were evaluated. Patient characteristics, clinical outcomes, and the utility of fungal biomarkers were then evaluated for continuation of antifungal therapy. Data were collected from the electronic health record (EPIC) and analyzed using SPSS (version. 28, IBM, Inc., Armonk, NY, USA) Data are presented as mean ± SD or percentages. A total of 56 COVID-19 patients were diagnosed with fungal co-infection and 117 COVID-19 + patients had no fungal infection. Significantly fewer female patients were in the fungal+ group compared to COVID-19 control patients (29% in fungal+ compared to 51% in controls p = 0.005). Fungal diagnostics were all significantly higher in fungal+ patients. These include 1,4-beta-D-glucan (BDG), fungal culture, and bronchoalveolar lavage galactomannan (BAL GM). Intensive care unit hospitalization, mechanical ventilation, and mortality in fungal+ patients with COVID-19 were significantly higher than in control patients. Finally, significantly more fungal+ patients received voriconazole, isavuconazonium, or amphotericin B therapies, whereas control patients received significantly more short-course fluconazole. COVID-19+ patients with fungal co-infection were significantly more likely to be in the ICU and mechanically ventilated, and they result in higher mortality compared to control COVID-19 patients. The use of fungal diagnostics markers were helpful for diagnosis.