bluuebunny/crossref_metadata_2025 huggingface dataset:
Circulating MicroRNAs associated with Bronchodilator Response in Childhood Asthma
Authors: Sharma Rinku , Tiwari Anshul , Kho Alvin T , Wang Alberta L. , Srivast Upasna , Piparia Shraddha , Desai Brinda , Wong Richard , Celedón Juan C , Peters Stephen P , Smith Lewis J , Irvin Charles G , Castro Mario , Weiss Scott T , Tantisira Kelan G , McGeachie Michael J
Published: June 2023

Rationale: Bronchodilator response (BDR) is a measure of improvement in airway smooth muscle tone, inhibition of liquid accumulation and mucus section into the lumen in response to short-acting beta-2 agonists that varies among asthmatic patients. MicroRNAs (miRNAs) are well-known post-translational regulators. Identifying miRNAs associated with BDR could lead to a better understanding of the underlying complex pathophysiology.
Objective: The purpose of this study is to identify circulating miRNAs associated with bronchodilator response in asthma and decipher possible mechanism of bronchodilator response variation.
Methods: We used available small RNA sequencing on blood serum from 1,134 asthmatic children aged 6 to 14 years who participated in the Genetics of Asthma in Costa Rica Study (GACRS). We filtered the participants into high and low bronchodilator response (BDR) quartiles and used DeSeq2 to identify miRNAs with differential expression (DE) in high (N= 277) vs low (N= 278) BDR group. Replication was carried out in the Leukotriene modifier Or Corticosteroids or Corticosteroid-Salmeterol trial (LOCCS), an adult asthma cohort. The putative target genes of DE miRNAs were identified, and pathway enrichment analysis was performed.
Results: We identified 10 down-regulated miRNAs having odds ratios (OR) between 0.37 and 0.76 for a doubling of miRNA counts and one up-regulated miRNA (OR=2.26) between high and low BDR group. These were assessed for replication in the LOCCS cohort, where two miRNAs (miR-200b-3p and miR-1246) were associated. Further, functional annotation of 11 DE miRNAs were performed as well as of two replicated miRs. Target genes of these miRs were enriched in regulation of cholesterol biosynthesis by SREBPs, ESR-mediated signaling, G1/S transition, RHO GTPase cycle, and signaling by TGFB family pathways.
Conclusion: MiRNAs miR-1246 and miR-200b-3p are associated with both childhood and adult asthma BDR. Our findings add to the growing body of evidence that miRNAs play a significant role in the difference of asthma treatment response among patients as it points to genomic regulatory machinery underlying difference in bronchodilator response among patients.
Trial registration: LOCCS cohort [ClinicalTrials.gov number: NCT00156819], GACRS cohort [ ClinicalTrials.gov number: NCT00021840]
Dynamic of bipartite and tripartite quantum coherence of a polarized 1/2-XXZ Heisenberg spin chain with modulated Dzyaloshinskii-Moriya interaction
Authors: Fouokeng G. C. , Ngueldjou C. Tahabo , Tchoffo M.
Published: June 2023

The dynamic analysis of quantum coherence of a polarized 1/2 − XXZ Heisenberg spins chain model with modulated Dzyaloshinskii-Moriya interaction and applied magnetic field, is investigated using quantum renormalization group approaches. In a thermodynamic limits, we derived the coherence factor and the monogamy of entanglement of a bipartite and tripartite states of the modulated system. We find that with increasing the anisotropy factor and decreasing the Dzyaloshinsky-Moriya factor Dz, the quantum coherence and the monogamy of entanglement decrease for the considered model of antiferromagnetic materials and exhibits non-analyticity around the critical point △ = 1 of the anisotropy factor. Note that, the decreasing is more important in the weak regime of the external magnetic field when applied. In addition, we perceive that the non-analytical behavior around the critical value of the anisotropy factor translate quantum phase transition from spin liquid to Néel phase and vice-versa depending on whether spin is localised on an even or odd site in the chain. The application of an external electric tens play a role in stabilizing the spins in preferred orientations and reenforce correlations beneficial for ferroelectricity that opens a route to switch magnetoelectricity with electric polarazation and vice-versa.
Prediction of Spherical Equivalent Refraction and Annual Myopia Progression Rate in Chinese Schoolchildren Based on Random Forest Model
Authors: Guo Chengyao , Luo Zhengfen , Lin Jianwei , Li Yuancun , Zhang Mingzhi
Published: June 2023

Purpose
To establish a machine learning (ML) model for predicting future spherical equivalent refraction (SER) and its annual progression rate in Chinese schoolchildren.
Methods
A total of 23,832 participants were analyzed, including 12,514 females and 11,318 males. The follow-up visits were conducted between February 2008 and June 2021. The SER value at a specific future time point was predicted based on the results of at least two cycloplegic refraction measurements. The prediction model was established using a random forest (RF) model. A five-fold cross-validation was used to select the parameters and train an optimal RF model for prediction. Axial position, SER values, and age were selected as predictors. The performance of the algorithm was evaluated using the coefficient of determination (R2), mean squared error (MSE), and mean absolute error (MAE).
Results
The RF algorithm had a great advantage in the detection of high myopia, with an R2 value of 0.944 in the training datasets. The established model achieved clinically acceptable predictions of SER values at a specific future time point. For the performance of the algorithm, the R2 achieved 0.994 in the training datasets, and 0.963 in the validation datasets, respectively. For the testing datasets, the MAE, MSE, and R2 achieved 0.489, 0.502, and 0.964 for the entire population, respectively.
Conclusions
Our ML model performs well in the prediction of SER and myopia progression in Chinese schoolchildren. Random forest algorithm has potential advantages in the detection of high myopia and thus provides evidence for precise individual intervention and control of myopia.
The original nerve of a greater occipital nerve schwannoma causing occipital neuralgia identified with magnetic resonance neurography
Authors: Nakagawa Koshi , Ozaki Mitsunori , Nakashima Shota , Mineji Kentaro , Ishii Kenji , Ito Masanori , Yasuoka Hironao , Nakamura Yoshinari
Published: June 2023

Background: Schwannomas are benign tumors arising from Schwann cells in the peripheral nerve and rarely develop at suboccipital area. We report a case of a greater occipital nerve schwannoma causing occipital neuralgia. The original nerve of the schwannoma was identified with magnetic resonance neurography.
Case presentation: A 69-year-old male patient was admitted for a suboccipital mass. Physical examination revealed an about 4cm beaded masses subcutaneously at suboccipital area. Magnetic resonance imaging showed that the lesions were not suppressed on 3 dimensional T2 weighting with fat suppression. Three dimensional fusion images (3 dimensional T2 weighting with fat suppression and 3-dimensional computed tomography) clearly revealed the original nerve of the lesions. The patient underwent a complete excision on the tumor. Histopathological examination diagnosed it as a schwannoma.
Conclusion: The present case is instructive in terms of not only a rare case but also the following of the original nerve with magnetic resonance neurography.
The Upper-Bound of the average achievable Rate of NOMA
Authors: baghani mina
Published: June 2023

The Non Orthogonal Multiple Access (NOMA) is a popular candidate for the next generation of wireless networks. Two advantages of NOMA are that it can achieve higher rate and support more users compared to the orthogonal multiple access (OMA). To support more users in NOMA system, we can assume there are infinite users in the system wanting to share one subchannel to derive the upper bound of the achievable rate of NOMA. In this article, the optimal power allocation function of infinite users in NOMA is derived which maximizes the average achievable rate of the system under the maximum power constraint. The performances of the proposed power allocation strategy are compared with simple case with only two users in NOMA. The simulation results show the gap between the average achievable rate and the outage probability of infinite users and two users in NOMA system.
Quantum implementaion of SM4 block cipher with less qubits
Authors: Luo Qingbin , Li Qiang , Li Xiaoyu , Yang Guowu , Shen Jinan , Zheng Minghui
Published: June 2023

SM4 cryptographic algorithm is a block cipher algorithm issued by China's state cryptographic administration and has become an international standard. we implement the quantum circuits of SM4 Block cipher by optimizing the number of qubits and the value of depth-times-width. When the S-box is implemented, four kind of improved quantum circuits of S-box are presented for different phases in SM4 based on composite field arithmetic. When optimizing the number of qubits, we implement the quantum circuit of SM4 by connecting the quantum subcircuits in series. The implemented quantum circuit of SM4 only uses 260 qubits, which is the least number of qubits used not only in implementing the SM4 quantum circuit, but also in implementing the block cipher algorithms with 8-bit S-box, 128-bit plaintext and 128-bit secret key. When optimizing the value of depth-times-width, we achieve it through parallel implementation. The trade-off quantum circuit uses a total of 288 quantum bits and the Toffoli depth is 1716. The depth-times-width is 494208, which is less than the existing best value 825792.
DNA methylation and gene expression profiling highlight retinol metabolism's vital role in Hepatocellular carcinoma development
Authors: Zhao Yanteng , Wan Kangkang , Wang Jing , Wang Shuya , Chang Yanli , Du Zhuanyun , Zhang Lianglu , Dong Lanlan , Zhou Dihan , Zhang Wei , Wang Shaochi , Yang Qiankun
Published: June 2023

Purpose
Abnormal DNA methylation patterns play a critical role in the development of hepatocellular carcinoma (HCC). However, the molecular mechanisms associated with these aberrantly methylated genes remain unclear. In this study, we aimed to comprehensively investigate the methylation-driven deregulated gene expressions in HCC using a large cohort of patients with diverse clinical characteristics.
Methods
Whole-genome bisulfite sequencing (WGBS) and RNA sequencing techniques were used to assess the methylation and gene expression profiles of HCC tissue and normal adjacent tissues (NATs). The potential function of candidate genes was then investigated using single cell RNA-seq (sc-RNA seq) data.
Results
We identified 132,773 differentially methylated regions (DMRs) and 4,322 differentially expressed genes (DEGs) between HCC and NATs. Integrated DNA methylation and RNA-seq data obtained 987 methylation-driven candidates, including 970 upregulated and 17 downregulated genes. Four retinol metabolic pathway genes, ADH1A, CYP2A6, CYP2C8, and CYP2C19, were found as hyper-downregulated genes, whose expressions could stratify HCC into three subgroups with distinct survival outcomes, immune cell infiltration, and tumor microenvironments. Validation of these findings in an independent dataset confirmed the high concordance and potential prognostic value of these genes. Sc-RNA seq data revealed the low expression of these genes in immune cells and highlighted their role in promoting malignant cell proliferation and migration.
Conclusion
This study provides an insight into the molecular characteristics of HCC, unraveling the involvement of retinol metabolism-related genes in HCC development and progression. These findings have implications for HCC diagnosis, prognosis prediction, and the development of therapeutic targets.
Multidrug-resistant Gram-negative bacilli in neonatal intensive care unit in South China
Authors: Tang Powei , Chen Xiaohong , Xiao Fei , Hu Yilin , Hao Jindou , Tian Jia , Liu Wanqu , Zhang Yu , Liu Peihui
Published: June 2023

Background Multidrug-resistant (MDR) gram-negative bacilli (MDR-GNB) infections have become a public health issue with time, especially, because of antibiotic abuse now. This study was aimed at elucidating the situation and clinical characteristics of MDR-GNB infectionsof a representative neonatal intensive care units (NICUs) in China.Methods Patients infected with MDR-GNB were collected between January 2017 and May 2022 in our hospital. Patient data on sex, premature delivery, gestational age, high-risk factors before delivery, delivery mode, invasive operation, premature rupture of membranes, routine blood test results, and outcomes were collected.Results Four hundred and twenty-five MDR-GNB were found in 242 patients. Escherichia coli and Klebsiella pneumoniae were the most commonly detected organisms (78.4% and 15.3%, respectively). Two hundred and seventeen extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae were detected. Only 11 cases (2.6%) of infection with carbapenem-resistant Enterobacteriaceae (CRE) were detected in 2 patients, and nine were Klebsiella pneumoniae, two were Escherichia coli. Among these 242 patients, 131 (54.1%) and 111(45.9%) patients showed colonization and infection, respectively. Sixty-seven patients had sepsis, and 55 of these patients developed sepsis due to infection with MDR-GNB. Birth weight < 1500 g was the risk factor for infection (p = 0.006, OR 3.338, 95%CI 1.418–7.858). And whose mothers had fever before delivery (p = 0.022, OR 2.679, 95%CI 1.153–6.221) and the birth weight less than 1500g (p = 0.029, OR 2.768, 95%CI 1.107–6.918) were the risk factors for sepsis.Conclusions Escherichia coli and Klebsiella pneumoniae were the most common MDR-GNB detected in NICU patients. Low birth weight and mothers had fever before delivery were the risk factors for sepsis to patients with MDR-GNB in NICU.
Molecular analysis of genetic diversity in Tulip(Tulipa gesneriana L.) cultivation varieties and germplasm resources by SRAP marker
Authors: Qin Douwen , Liu Weiqiang , Tian Jiting , Liu Bin , Ju Xiuting
Published: June 2023

The taxonomy of Tulipa gesneriana L. poses a challenging problem as traditional morphological methods no longer suffice to meet the demands. In recent years molecular marker technology has been increasingly utilized for population identification and classification as well as for the analysis of genetic diversity and kinship relationships among tulip cultivation varieties and germplasm resources.To elucidate the genetic diversity of different tulip cultivation varieties and germplasm resources This study was carried out to estimate the genetic diversity kinship relationships between 40 tulipa cultivation varieties and germplasm resources using SRAP marker system .The results showed that out of 43 pairs of primers 21 pairs with high polymorphism were selected and 249 clear and stable bands were amplified including 245 polymorphic bands and Percentage of Polymorphism Bands (PPB) is 98.39%.The genetic similarity index of 40 tulip cultivation varieties and germplasm resources is between 0.5020–0.8675 and the genetic diversity parameters including the Number of alleles (Na) Effective number of alleles (Ne) Nei's gene diversity index (H) Shannon’s information index (I) and polymorphic information content (PIC) are 1.9810 1.5149 0.3042 0.4603 and 0.3212 respectively. This indicates that the genetic diversity of 40 tulip cultivation varieties and germplasm resources is rich .The cluster results analysis and PCoA(principal coordinate analysis) divided 40 tulip cultivars into two major groups A and B (Christmas Magical Banja Luka) with the first group (A) further divided into two subgroups A1 and A2 (Madame Lefeber). These results demonstrate that SRAP can accurately reflect the genetic differences of 40 tulip cultivation varieties and germplasm resources at the molecular level.
Study on Determining the Blood GlucoseConcentration During an IntravenousInjection Using Volterra Integral Equations
Authors: Khidir Ahmed , Alfaifi Waad , Alsharari Salihah , Alanazi Ibtisam , Alyasi Lujain
Published: June 2023

In this study, the mathematical model for determining the blood glucose concentration during an intravenous injection has been solved throw Volterra integral equation and using Chebyshev spectral method. The method is based on the blending of the Chebyshev pseudo spectral method and its implementation procedure reduces theVolterra integral equation to a system of algebraic equations that are easy to solve. Forthe practical application of the method, a mathematical model in medical science fordetermining the blood glucose concentration during an injection has been solved. Tables and figures were generated to verify the accuracy and convergence of the method.The results demonstrate that the method is efficient, convergent and accurate to theexact solution.
A clinical survey of the current status of difficult airway information dissemination
Authors: Shi Yun , Lan Dongyi , Zhang Song , Dong Chenbin
Published: June 2023

Background
Difficult airway is one of the greatest challenges faced by anesthesiologists and is a potential risk factor for increased fatality in patients. To date, there is no well-established and all-around difficult airway notification system in China, which has recently been recommended by existing guidelines to improve the care of patients with known difficult airways. This study aimed to investigate the status of critical information communication concerning difficult airway management and the current knowledge of the difficult airway notification system in our institute.
Methods
Vital information required to establish a difficult airway registry and notification system were collected through a literature review and expert suggestions. After approval by the Research Ethics Board, three online questionnaires were developed and sent to surgeons, anesthesiologists, and proxies of the patients. Knowledge of difficult airways and the status of difficult airway information dissemination among the three groups were investigated. The willingness of the participants to take part in the difficult airway registry and notification system was assessed.
Results
A significant difference was observed between what was expected and what was the reality to when the anesthesiologist retrieved the airway information of a patient with known airway difficulty. A significantly higher proportion of anesthesiologists would verbally disseminate airway information to the surgeons and other anesthesiologists, while a significantly higher proportion of anesthesiologists would disseminate airway information to the patients both verbally and in writing. Furthermore, a significantly higher proportion of anesthesiologists would communicate the detailed information to other anesthesiologists rather than to the patients or the surgeons. Most participants agreed with the necessity of setting up a difficult airway registry and notification system and were willing to take part in developing the system despite the significantly lower percentage in the patient group.
Conclusions
Difficult airway information is currently ineffective, which leads to a large gap between the expectation and reality of the anesthesiologist when caring for a patient with a difficult airway. Thus, a difficult airway registry and notification system that has a solid foundation for patients, surgeons, and anesthesiologists should be developed.
Trial registration:
The study was approved by the Research Ethic Board of Children’s Hospital of Fudan University and was registered at www.chictr.org.cn (registration number: ChiCTR2200063995).
The properties of black cherry tree wood (Prunus serotina Ehrh.) and its susceptibility to fungal decomposition in areas where it is secondary and invasive: a case study in the Kampinos National Park (Poland)
Authors: Marciszewska Katarzyna , Szczepkowski Andrzej , Lachowicz Hubert , Antczak Andrzej , Szadkowska Dominika , Suchodolski Jakub
Published: June 2023

The properties of black cherry wood and its susceptibility to fungal decay were studied in the secondary range of the species, on six trees from two stands growing in poor, acidic soils of the Albic Arenosol and Gleic Albic Podzol type, albeit differing in moisture and organic carbon and nitrogen content. Wood from trees growing in wetter and richer soils had better physical properties: of 95 determined parameters, 80 showed significant differences in favor of this wood – for example, wider rings (3.25 mm) on average and a higher density (662.71 kg/m3 at 12% humidity). The content of extractives in the wood of trees from more moist and rich soil plots was 1.5 times higher than in the case of trees grown in poorer and drier soil. Of 44 extractives determined by gas chromatography with mass spectrometry, six with confirmed antifungal properties were found in the wood of trees grown in wetter and richer soil, and only three in the wood of trees from drier and poorer soil: their percentage share was 62.93% and 8.68% of peak area respectively. This wood also turned out to be less susceptible to fungal decay: in general, however, the degree of decay was low, and of the four basidiomycete species tested, only Trametes versicolor caused a loss of more than 10% of wood mass in the samples from both sites. The obtained results show that black cherry has the ability to benefit from even small differences in the richness of generally poor soils and habitats to which it was introduced in the secondary range, resulting in the diversity of features and properties of its wood.
Prognostic value of peritoneal scar-like tissue in patients with peritoneal metastases of ovarian origin presenting for curative-intent cytoreductive surgery
Authors: Asmar Antoine El , Pop Florin , Helou Etienne El , Demetter Pieter , Veys Isabelle , Polastro Laura , Bohlok Ali , Liberale Gabriel
Published: June 2023

Background Complete cytoreductive surgery (CRS) ± hyperthermic intraperitoneal chemotherapy (HIPEC), remain the gold standard in the treatment of peritoneal metastases of ovarian cancer (PMOC). Given the increasing rate of neoadjuvant chemotherapy in patients with high PCI, prior abdominal surgeries, inflammation and fibrotic changes, the benefit of removing any “peritoneal scar-like tissues” (PST) during CRS, hasn’t been thoroughly investigated. Our objective in this retrospective cohort was to identify the proportion of malignant cells positivity in PST of patients with PMOC, undergoing curative-intent CRS ± HIPEC.Methods This is a retrospective study, conducted at our comprehensive cancer center, including patients with PMOC, presenting for curative-intent CRS. During CRS, benign-looking peritoneal lesions, lacking the typical hard nodular, aggressive, and invasive morphology, were systematically resected or electro fulgurated. PSTs were analyzed for the presence of tumoral cells by our pathologist. Correlations between the presence of PST and their positivity, and the different patients’ variables, were studied.Results In 51% of patients, PST harbored malignant cells. Those were associated with poorly differentiated serous tumors, a high PCI (> 8) and a worse DFS: 17 months in the positive PST group versus 29 months in the negative PST group (p = 0.05), on univariate analysis. Multivariate analysis revealed that PCI > 8 and poorly differentiated primary tumor histology were correlated with a worse DFS, and that higher PCI and advanced FIGO were correlated with a worse OS.Conclusion Benign-looking PST harbors malignancy in 51% of cases. The benefit of their systematic resection and their prognostic value should be further investigated in larger cohorts.
PD-L1-expressing cancer-associated fibroblasts induce tumor immunosuppression and contribute to poor clinical outcome
Authors: Kawasaki Kento , Noma Kazuhiro , Kato Takuya , Ohara Toshiaki , Tanabe Shunsuke , Takeda Yasushige , Matsumoto Hijiri , Nishimura Seitaro , Kunitomo Tomoyoshi , Akai Masaaki , Kobayashi Teruki , Nishiwaki Noriyuki , Kashima Hajime , Maeda Naoaki , Kikuchi Satoru , Tazawa Hiroshi , Shirakawa Yasuhiro , Fujiwara Toshiyoshi
Published: June 2023

The programmed cell death 1 protein (PD-1)/programmed cell death ligand 1 (PD-L1) axis plays a crucial role in tumor immune suppression, while the cancer-associated fibroblasts (CAFs) have various tumor-promoting functions. To determine the advantage of immunotherapy, the relationship between the cancer cells and the CAFs was evaluated in terms of the PD-1/PD-L1 axis. Overall, 140 cases of esophageal cancer underwent an immunohistochemical analysis of the PD-L1 expression and its association with the expression of the α smooth muscle actin (SMA), fibroblast activation protein (FAP), and the CD8, and forkhead box P3 (FoxP3) cells. The relationship between the cancer cells and the CAFs was evaluated in vitro, and the effect of the anti-PD-L1 antibody was evaluated using a syngeneic mouse model. A survival analysis showed that the PD-L1+ CAF group had worse survival than the PD-L1- group. In vitro and in vivo, direct interaction between the cancer cells and the CAFs showed a mutually upregulated PD-L1 expression. In vivo, the anti-PD-L1 antibody increased the number of dead CAFs and cancer cells, resulting in increased CD8+ T cells and decreased FoxP3 + regulatory T cells. We demonstrated that the PD-L1-expressing CAFs lead to poor outcomes in patients with esophageal cancer. The cancer cells and the CAFs mutually enhanced the PD-L1 expression and induced tumor immunosuppression. Therefore, the PD-L1-expressing CAFs may be good targets for cancer therapy, inhibiting tumor progression and improving host tumor immunity.
Non-Adherence with Physiotherapeutic Rehabilitation – A Cross-Cultural Adaption of Compliance Parameters into German
Authors: Hakam Hassan Tarek , Lettner Jonathan , Kersten Sebastian , Hofmann Hannes , Mühlensiepen Felix , Prill Robert , Becker Roland
Published: June 2023

Background: Compliance with rehabilitative physiotherapeutic measures leads to an improvement in outcomes in patients suffering from a variety of musculoskeletal conditions. Till date, a tool in assessing the parameters that lead to non-adherence to physical therapy does not exist in the German language. The objective of this paper is to cross-culturally adapt a non-compliance questionnaire to German.
Methods: In reference to the “Guidelines for the Process of Cross-Cultural Adaption of Self-Reported Measures”, the questionnaire was translated into German followed by a back-translation into the original language. An expert committee met and refined the pre-final version. A preliminary version was handed out to patients for the evaluation of the quality of the resulting German version. A simple statistical analysis was carried out to evaluate the final version.
Results: After the forward and back-translation of the questionnaire, some discrepancies were discovered between the translators on one hand and between the back translations and the original document on the other. The statistical analysis showed satisfactory results regarding the quality of the questionnaire.
Conclusion: The translation and adaption of the items proved to have a high degree of reliability. The German version will also be made available for other German-speaking researchers and used in the evaluation of a mobile application-based physical therapy regimen by the authors of the paper.
Registration: The objective of this paper is the cross-cultural adaption of a questionnaire. No registration was deemed necessary.
Lateral rectus approach versus ilioinguinal approach for acetabular fractures: A retrospective comparative study
Authors: Zhou Yue , Zhou Qingsong , Wang Shengtao , Zhao Ming , Cai Jieyong , Wang Heng , Li Zhengjiang , Deng Wei , Yin Yong
Published: June 2023

Background
The surgical management of acetabular fractures is challenging, and although new minimally invasive surgical approaches are being developed, the optimal surgical approach is still under discussion. We compared the clinical and radiographic findings of two surgical approaches for acetabular fractures: the lateral rectus approach (LRA) and the ilioinguinal approach (IA).
Methods
A consecutive cohort of 42 patients treated by a single surgeon using the LRA or IA from June 2015 to December 2018 with displaced acetabular fractures with a minimum 1-year clinical and radiographic follow-up were included. Clinical data were reviewed for fracture pattern, time to surgery, operative time, blood loss, quality of reduction, and perioperative complications. Fracture reduction quality was evaluated according to the Matta criteria. The Merle D’Aubigne-Postel and Harris Hip Score (HHS) were used for hip function outcomes.
Results
The complications, fracture reduction quality, Merle D’Aubigne-Postel score, and HHS were not significantly different between the approaches. There were statistically significant differences in the mean operative time (P = 0.003), intraoperative blood loss (P = 0.012), wound drainage (P = 0.031), and blood transfusion rate (P = 0.005) between the lateral rectus approach and the ilioinguinal approach.
Conclusion
Compared with the ilioinguinal approach, the lateral rectus approach is promising, especially for fractures in the quadrilateral area. The approach benefits fracture exposure, reduction, and fixation, thus shortening the operative time and reducing intraoperative bleeding.
Trial registration
Chinese Clinical Trial Registry, ChiCTR-2100043982, Registered on 6 March 2021
Level of Evidence: Level IV, retrospective comparative study.
Analysis of Cortical Spread Depression in Rats Induced to Hyperprolactinemia and Treated with Melatonin
Authors: Silva Ewerton Fylipe de Araújo , Gomes José Anderson da Silva , de Oliveira Maria Luísa Figueira , Noya Arthur Gabriel Alves Furtado de Carvalho , Magalhães Carolina Peixoto , Silva João Vitor da , Silva Luíz Henrique da , Tenório Bruno Mendes , Tenorio Fernanda das Chagas Angelo Mendes
Published: June 2023

Introduction: Cortical spreading depression (CSD) is an electrophysiological phenomenon used experimentally to analyze the direct modulation of the electrical activity of cortical neurons, and the dissemination of this wave may be associated with several pathological factors. Hyperprolactinemia is a pathological condition related to high plasma levels of prolactin, which, at normal levels, influences brain functions. However, high levels of this hormone can act differently in the cerebral cortex. Melatonin is an influential hormone in the central and peripheral nervous system, playing a cerebrovascular, neuroendocrine, neuroimmune and neuroprotector regulatory role.
Objectives: The objective was to analyze CSD in rats induced to hyperprolactinemia and treated with melatonin.
Results: 64 rats were used, which were divided into two treatment periods (30 and 60 days), subdivided into 4 groups each: Control, Vehicle, Hiper (rats induced to hyperprolactinemia) and Hiper+mel (rats induced to hyperprolactinemia and treated with melatonin). After treatment, the animals were anesthetized for analysis of the CSD propagation velocity, which was calculated based on the distance between the two recording electrodes, and the time spent by the CSD to cover this distance. The recording was performed at the two parietal points of the right cerebral hemisphere, for a continuous period of 4 hours. The ANOVA results of the animals treated for 30 days showed that the control group had an average speed of 3.43 ± 0.11 mm/min and the vehicle 3.10 ± 0.04 mm/min. In the Hyper group, the mean speed was 3.38 ± 0.16 mm/min, while the Hyper+mel group had a speed of 2.21 ± 0.02 mm/min. As for the animals treated for 60 days, the control group obtained a speed of 3.21 ± 0.22 mm/min, while the vehicle 3.06 ± 0.17 mm/min.
The hyper group 4.65 ± 0.16 mm/min and the hyper+mel 2.34 ± 0.19 mm/min. There was a significant increase in the hyper group compared to the others, and a significant decrease in the hyper+mel group compared to the other groups.
Conclusions:It is concluded that hyperprolactinemia has a direct effect on increasing the speed of CSD, on the other hand, the neuroprotective effects of melatonin were sufficient to establish efficiency against hyperprolactinemia.
A comprehensive investigation on the propagation properties of a Generalized Hermite cosh-Gaussian beam through atmospheric turbulence
Authors: Saad Faroq , Belafhal Abdelmajid
Published: June 2023

The impact of atmospheric turbulence on the properties of a Generalized Hermite cosh-Gaussian beam (GHCGB) is investigated. The formula for the average intensity of the propagated GHCGB in turbulent atmosphere is derived using the extended Huygens-Fresnel integral diffraction and Rytov method. Some graphical representations have examined to study the influences of turbulent atmosphere and incident beam parameters on the average intensity of the considered beam. Results show that the average intensity strongly depends on the structure constant of the turbulent atmosphere and the incident beam parameters such as the Gaussian waist width, the decentered cosh parameter and the beam orders. It’s shown that the initial profile of the beam remains unchanged within shorter propagation distance and spreads more rapidly on a Gaussian like distribution for the lager strong turbulent and the smaller beam parameters, but the reverse behavior will formed on a dark hollow distribution as the incident beam parameters are large. The paper results are useful for the atmospheric optics applications in remote sensing and free-space optical communications.
An Algebraic Optimization Model to Conserve Water Environment by Distributing Manure for Harvesting
Authors: Dione Déthié , Mbainaissem Teubé Cyrille , Koné Bakary
Published: June 2023

An overuse of manure on farmland creates a major environmental problem. When dumping more manure than the crops need as fertilizer, it causes an excess of manure in those fields. Rainwater drains these excessive amounts from the surface into the water reservoirs (rivers and lakes), where they pollute the water, nourish algae, and harm the fish. We develop an algebraic optimization model to formulate for the selection of the right field at the right time so that the environmental damage is limited. We gather instance data from a region of topologically connected reservoirs in northern Senegal and their adjacent farmlands. This mathematical problem then can be tackled by standard solvers for linear optimization problems. When applied in practice, this solution can improve the water quality by reducing the amount of manure and its main components, Nitrogen, Phosphorus, and Potassium.
Generation of doughnut Humbert beam by a gradient-index medium
Authors: Nossir N. , Dalil-Essakali L. , Belafhal A.
Published: June 2023

In this paper, we generate a new doughnut Humbert beam from a Whittaker-Gaussian (WG) beam propagating through a gradient-index medium (GIM). Based on the extended Huygens-Fresnel diffraction integral, the analytical expression of the intensity distribution for doughnut Humbert beam is derived and discussed through numerical examples. The obtained results indicate that the diffracted beam evolves periodically versus the propagation distance in GIM and its behavior depends interestingly on the beam initial parameters and the gradient-index parameter. Our results can be useful for some applications such as in multi-dimensional optical manipulation, remote sensing domain and imaging.
High-Fat Diet and Vitamin D Effects on Contractile Performance of Isolated Mouse Soleus and EDL
Authors: Shelley Sharn P. , James Rob S. , Eustace Steven J. , Eyre Emma L.J. , Tallis Jason
Published: June 2023

Evidence suggests vitamin D (VD) could mitigate adverse effects of obesity on skeletal muscle (SkM) function, however, this is yet to be directly investigated. Therefore, this study used the work-loop technique to examine effects of high dose dietary VD supplementation on contractile performance of isolated SkM. Female mice (N = 37) consumed standard (SLD) or high-fat diet (HFD), with or without VD (20,000 IU/kg− 1) for 12-weeks. Soleus and EDL (N = 8–10) were isolated and absolute and normalised (relative to muscle size and body mass) isometric force and power output (PO) were measured, and fatigue resistance determined. Absolute and normalised isometric force and PO of the soleus were unaffected by diet (P > 0.087). However, PO normalised to body mass was reduced in HFD groups (P < 0.001). Isometric force of the EDL was unaffected by diet (P > 0.588). HFD evoked reduced EDL isometric stress (P = 0.048) and absolute and normalised PO (P < 0.031), but there was no effect of VD (P > 0.493). Cumulative work during fatiguing contractions was lower in HFD treated SkM (P < 0.043), but the rate of fatigue was unaffected (P > 0.060). This study uniquely demonstrated that high dose dietary VD had limited effects on SkM contractile function and did not offset the demonstrated adverse effects of HFD. However, there was non-significant small and moderate effects suggesting improvement in EDL muscle performance and animal morphology in HFD VD groups. Given trends observed, coupled with the proposed inverted U-shaped dose-effect curve, future investigations are needed to determine dose/duration specific responses to VD, which may culminate in improved function of HFD treated SkM.
The clinical features of patients who underwent bladder augmentation of cloacal exstrophy and their functional outcomes: The results of a nationwide survey in Japan
Authors: Yano Keisuke , Sugita Koshiro , Kawano Takafumi , Murakami Masakazu , Harumatsu Toshio , Onishi Shun , Yamada Koji , Muto Mitsuru , Ieiri Satoshi , Kubota Masayuki
Published: June 2023

PURPOSE
Cloacal exstrophy (CE) patients may need bladder reconstruction after initially undergoing surgery to obtain continence and improve their quality of life. This study attempts to clarify the clinical features of CE patients who underwent bladder augmentation (BA) and their urinary functional outcomes based on a nationwide survey in Japan.
METHODS
A questionnaire survey was conducted, and 150 CE patients were enrolled. Their clinical characteristics and urinary outcomes were reviewed.
RESULTS
BA was performed in 52 patients (34.7%). Most cases underwent early bladder closure at initial surgery in neonate period. The age at the BA was performed 6.4 [6–9.0] years old. Among them, the most used organ for BA was ileum (n = 30, 57.7%). Regarding the outcomes, the age when the renal function was evaluated was 14.0 [10.0–20.5] years old and the serum creatinine level was 0.44 [0.36–0.60] (mg/dl). Clean intermittent catheterization was required in 37 (71.2%) patients. On the other hand, no dialysis or kidney transplantation was necessary in any of these patients.
CONCLUSION
The renal function and conditions of patients who underwent BA were relatively well preserved. Individualized management with a stepwise surgical approach for CE patients should thus be considered in the future.
Two classes of inverse problems for dual matrices
Authors: Fan Ranran , Zeng Min , Yuan Yongxin
Published: June 2023

Dual matrices play an important role in robotics, kinematic analysis, spatial synthesis mechanisms, and so on. In this paper, two classes of inverse problems for dual matrices are discussed and the solvability conditions and the general solutions are achieved by applying the singular value decomposition and the generalized inverse. Further, the corresponding approximation problems are considered and the optimal approximate solutions are deduced by using some matrix decompositions and the Kronecker product. Finally, a numerical example is presented to verify the correctness of our results.
15A24, 65F18
Laser based optical interferometer manometer design for primary pressure standard in India
Authors: Das Manoj , Ghosh Sandip Kumar , Kumar Kuldeep , James Elizabeth Jeessa , Singh Megha , Kumar Ashok
Published: June 2023

The SI unit of pressure, i.e. Pascal is realized with mechanical devices such as ultrasonic interferometer manometers and pressure balances for the pressure range 1 Pa to 100 kPa. Recently, optical interferometer manometers are being used to realize Pascal. Such a realization is mercury-free and environmentally friendly and does not depend on any mechanical motions as in piston gauges and is based on physical constants. It consists of an optical Fabry-Perot cavity as a refractometer and is based on the measurement of the resonant frequency of the cavity using lasers. In this paper, we report the theoretical calculations for such an optical cavity and discuss various parameters for the laser required for developing such a cavity-based refractometer system. We present the mechanical design for the dual cavity and the effect of pressure on the elastic deformation of such cavities using finite element analysis. We present an all-fiber optical set-up for the lasers, to be used for the next generation of primary pressure standards in the barometric region of pressure at CSIR-National physical laboratory, India.
Section-Type constraints on the choice of linguistic mechanisms in research articles: a corpus-based approach
Authors:   , Ivanova Iverina
Published: June 2023

This thesis investigates the structure of research articles in the field of Computational Linguistics with the goal of establishing that a set of distinctive linguistic features is associated with each section type. The empirical results of the study are derived from the quantitative and qualitative evaluation of research articles from the ACL Anthology Corpus. More than 20,000 articles were analyzed for the purpose of retrieving the target section types and extracting the predefined set of linguistic features from them. Approximately 1,100 articles were found to contain all of the following five section types: abstract, introduction, related work, discussion, and conclusion. These were chosen for the purpose of comparing the frequency of occurrence of the linguistic features across the section types. Making use of frameworks for Natural Language Processing, the Stanford CoreNLP Module, and the Python library SpaCy, as well as scripts created by the author, the frequency scores of the features were retrieved and analyzed with state-of-the-art statistical techniques. The results show that each section type possesses an individual profile of linguistic features which are associated with it more or less strongly. These section-feature associations are shown to be derivable from the hypothesized purpose of each section type. Overall, the findings reported in this thesis provide insights into the writing strategies that authors employ so that the overall goal of the research paper is achieved. The results of the thesis can find implementation in new state-of-the-art applications that assist academic writing and its evaluation in a way that provides the user with a more sophisticated, empirically based feedback on the relationship between linguistic mechanisms and text type. In addition, the potential of the identification of text-type specific linguistic characteristics (a text-feature mapping) can contribute to the development of more robust language-based models for disinformation detection.
The concepts of social solidarity and social partnership as prerequisites for the formation of corporate culture
Authors: Tarutin N. V.
Published: June 2023

This research is devoted to the analysis of the concepts of social solidarity and social partnership as prerequisites for the formation of corporate culture of organizations. Currently, the concept of social solidarity is an important tool for ensuring social justice and sustainable development of society. The concept of social partnership, in turn, allows employers and employees to cooperate effectively in solving various socio-economic problems. The study analyzes the methodological consolidation of the concepts of social solidarity and social partnership, and also presents their criticism. The author conducted a comparative analysis demonstrating the advantages and disadvantages of each of the concepts under consideration. Based on the results obtained during the study, the principles of implementing the concepts of social partnership and social solidarity in the formation of the corporate culture of the organization were developed. In conclusion, the author concludes that the development of concepts of social solidarity and the establishment of social partnership in the organization is a prerequisite for the successful formation of a corporate culture that contributes to improving the efficiency of the organization and employee satisfaction.
Functional characteristics of university press service
Authors: Bougrov A. Yu.
Published: June 2023

The press services are deeply integrated into the universities’ reputation management and provide the interaction with students, applicants, employers and the international academic community. The effectiveness of the implementation of the communicative potential of university press services is achieved through timely monitoring of public opinion, the establishment and adjustment of feedback from applicants and their parents, as well as the target groups enlisted above. The activities of the press service, its structure and functions are determined by the development of information and communication technologies, including new media, social media, university platforms and various cross-platform messengers. In this context, the experience of organizing and functional features of the university press service in new media and social networks seems worth studying for both theoretical and practical point sides.
Super resolution direction finding technique of vortex electromagnetic wave radar in missing mode
Authors: Guo Huping
Published: June 2023

Vortex electromagnetic waves have superior performance over electromagnetic waves. In order to improve the radar super-resolution lateralization technique in its missing modes, this study proposes to start from the perspective of mode missing. The missing modes are reconstructed using the Adaptive Step Size Gradient Descent (ASSGD) method by exploiting the features of the missing modes. The linear minimum mean square error (LMMSE) estimation method is also used to solve the problem of poor reconstruction accuracy due to the Missing Modes. The Missing Modes Iterative Adaptive Approach (MMIAA) algorithm and Missing Modes Sparse Learning via Iterative Minimization (MMSLIM) algorithm are then used. Minimization (MMSLIM) algorithm to recover missing modes. The results showed that the RMSEs of the recovery errors of MMSLIM, MMIAA and ASSGD were 0.16, 0.31 and 0.82 respectively at a modal missing ratio of 0.7, while ASSGD fails to recover the missing modal data at a modal missing ratio of 0.9. The overall data quality of the azimuthally estimated RMSE was average when the signal-to-noise ratio was at [–5, 10] dB. And the curve becomes flatter when it reaches 15 dB or more, indicating that MMSLIM, MMIAA has important theoretical and practical value.
An ED-PSO model updating algorithm for structure health monitoring of beam-like structures
Authors: Wang Can , Li Dayang , Kaewniam Panida , Wang Jie , Al Hababi Tareq
Published: June 2023

Cracks and other damages generated during the service of bridges can reduce the load bearing capacity and threaten operational safety.Finite Element Model Updating (FEMU), as one of the important means of structural health diagnosis, identifies structural damage through changes in model parameters. The three key factors of FEMU are updating variables, objective functions, and optimization algorithms. The poor selection of the above three factors in existing research leads to high calculation errors in model updating, and inevitably lead to the inability of the finite element model to carry out structural health monitoring, affecting the normal operation of the structure. In order to solve the above problems, this paper combines previous research and establishes a model updating algorithm based on the combination of eigenvector difference approach and particle swarm optimization (ED-PSO). The validity and accuracy of this method are verified by finite element analysis of a simply supported beam. Compared with the existing model updating algorithms based on the combination of static and dynamic methods and particle swarm optimization (CSD-PSO), the results show that the proposed ED-PSO model updating algorithm has higher accuracy and is expected to be better applied to bridge finite element model updating research.