bluuebunny/crossref_metadata_2025 huggingface dataset:
Polyethylene‐b‐poly(ethylene glycol) diblock copolymers: New synthetic strategy and application
Authors: Li Peiyuan , Fu Zhisheng , Fan Zhiqiang
Published: April 2015

Polyethylene‐b‐poly (ethylene glycol) (PE‐b‐PEG) was successfully synthesized by a coupling reaction of hydroxyl‐terminated polyethylene (PE‐OH) and isocyanate‐terminated poly (ethylene glycol) (PEG‐NCO). PE‐OH was prepared by coordination chain transfer polymerization (CCTP) using 2,6‐bis[1‐(2,6‐diisopropylphenyl)imino ethyl] pyridine iron (II) dichloride /dry ethylaluminoxane (DEAO) /diethyl zinc (ZnEt2) as catalyst and subsequent in situ oxidation with oxygen. The active centers of this catalyst system were counted, indicating that the active centers were more stable using DEAO as cocatalyst than using dry methylaluminoxane (DMAO) as cocatalyst. PEG‐NCO was synthesized through the condensation reaction of monomethylpoly(ethylene glycol) (PEG) with isophoronediisocyanate (IPDI). Subsequently, the thermal characterization, morphological characterization and the application of these diblock copolymers was investigated. The results indicated that the diblock copolymers were effective compatilizers for polyethylene/poly(ethylene glycol) blends. Meanwhile, they were excellent surface modification agents for polyethylene membrane and glass sheet, it can efficiently turn a hydrophobic surface into a hydrophilic surface, or vice versa. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42236.
Novel composite sandwich structure from green materials: Mechanical, physical, and biological evaluation
Authors: Mohareb Ahmed S. O. , Hassanin Ahmed H. , Badr Alaa A. , Hassan Khaled T. S. , Farag Ramsis
Published: April 2015

Flax and Jute fabrics were used as reinforcements with polyester resin to form composite skins while poplar particleboard was used as a core for making composite sandwich structures by applying vacuum assisted resin transfer molding (VARTM) technique. Mechanical, physical, and biological properties of these novel composite sandwich structures were evaluated. The results showed that the proposed engineered panels have superior mechanical properties that are suitable for different structural applications compared with conventional particleboards. When compared with the control panels, significant enhancement on Modulus of elasticity (MOE) and Modulus of rupture (MOR) were achieved. On the other hand, the results indicated that the proposed panel composites exhibit better dimensional stability compared with poplar particleboard control panels. In addition, the proposed composite sandwich structures proved resistant against the decay fungi after 12 weeks of fungal exposure. Obviously, the developed composite panels could be used in a wide variety of applications. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42253.
Ten‐years, single‐center experience with arterial duct stenting in duct‐dependent pulmonary circulation: Early results, learning‐curve changes, and mid‐term outcome
Authors: Santoro Giuseppe , Gaio Gianpiero , Giugno Luca , Capogrosso Cristina , Palladino Maria Teresa , Iacono Carola , Caianiello Giuseppe , Russo Maria Giovanna
Published: April 2015

Objectives

To evaluate early results, learning‐curve changes, and mid‐term outcome of arterial duct (AD) stenting in congenital heart disease with duct‐dependent pulmonary circulation (CHD‐DPC) in a high‐volume, tertiary referral center.

Background

In spite of wide acceptance as cost‐effective alternative to surgical palliation, AD stenting indications, results and mid‐term outcome still largely depend on small series, experiences in particular subsets of patients or multicenter series with different approaches and interventional philosophy.

Methods

Between April 2003 and December 2013, 119 patients underwent AD stenting as lower‐risk palliation of CHD‐DPC at our Institution. Procedural and mid‐term follow‐up data of these patients are reported.

Results

The procedure was successfully completed in 93.3% of cases, with a complication rate and in‐hospital mortality of 17.6% and 3.6%, respectively. No patient underwent rescue surgical shunt but elective Blalock‐Taussig shunt was needed in 15 patients (13.5%). Over time, favorable trends toward higher feasibility and efficacy in complex ductal anatomy as well as lower procedural risk were recorded. Presurgical cardiac catheterization (n = 36) showed significant and balanced pulmonary artery (PA) growth (Nakata Index +113 ± 101%; left PA z‐score +87 ± 52%; right PA z‐score +97 ± 53%, P < 0.001 for all comparisons), without significant changes of left‐to‐right PA diameter ratio. PA growth was significantly better in patients with severely hypoplastic PAs at the time of duct stabilization (Nakata Index increase 194 ± 115 vs. 75 ± 61%, P < 0.001).

Conclusions

AD stenting is feasible and effective at low‐risk in a high percentage of patients with CHD‐DPC, promoting significant and balanced PA growth mainly in patients with hypoplastic main PAs at duct stabilization. © 2015 Wiley Periodicals, Inc.
Nine de novo duplications affecting both maternal and paternal chromosomes and an inherited 15q11.2 deletion, in a patient with developmental delay
Authors: Tayeh Marwan K. , Rocco Tracy , Ackley Todd , Ernst Leslie , Glover Thomas , Innis Jeffrey W.
Published: April 2015

Key Clinical Message

A patient with developmental delay and nine, de novo, tandem duplications affecting eight different chromosomes that arose on both maternal and paternal chromosomes indicating a vulnerable zygotic or early postzygotic period of development for these errors, potentially affected by genetic and nongenetic factors.
Recurrent abdominal pain in 52‐year‐old male
Authors: De Palma Giovanni D. , Maione Francesco , Esposito Dario , Siciliano Saverio , Gennarelli Nicola , Cassese Gianluca , Forestieri Pietro
Published: April 2015

Key Clinical Message

Intussusception of the appendix is a rare condition. Symptoms vary widely, whereas some patients are asymptomatic. Diagnosis is generally challenging and few cases have been diagnosed by colonoscopy. It is important to recognize the endoscopic appearance of this entity in order to avoid the potential hazard of an inadvertent “polypectomy”.
Potentially lethal ACE‐inhibitor‐induced angioedema in a child
Authors: Bukhari Esraa , Safdar Osama Y. , Shalaby Mohammed , AlSharif Shafiqa M.J. , Alsufiany Khoulod , Kari Jameela A.
Published: April 2015

Key Clinical Message

We report a case of a 9‐year‐old female with known end‐stage kidney disease who presented with sudden onset tongue swelling. A diagnosis of angiotensin‐converting enzyme inhibitor‐induced angioedema related to bradykinin accumulation was made. Her symptoms resolved shortly after discontinuation of captopril. Early diagnosis can save patients from severe upper airway obstruction.
Nontuberculous mycobacterial infection in a patient with myelofibrosis: case report and concise review
Authors: Henriquez‐Camacho Cesar , Martinez‐Barranco Pilar , Velasco Maria , Villafuerte‐Gutierrez Paola , Losa Juan
Published: April 2015

Key Clinical Message

A 70‐year‐old patient having massive refractory ascites in the course of idiopathic myelofibrosis was diagnosed of peritoneal extramedullary hematopoiesis and developed an overwhelming nontuberculous mycobacterial infection. The case describes this unusual infection and highlights the need for additional studies to confirm the etiology of ascites in primary myelofibrosis.
Synthesis of a Fe–Ni Alloy on a Ceria Support as a Noble‐Metal‐Free Catalyst for Hydrogen Production from Chemical Hydrogen Storage Materials
Authors: Mori Kohsuke , Taga Tomohisa , Yamashita Hiromi
Published: April 2015

Bimetallic FeNi nanoparticles supported on CeO2 was proven to be effective for hydrogen production from ammonia–borane (NH3–BH3) as a noble‐metal‐free catalyst. Impregnation of iron and nickel ions with the CeO2 surface followed by in situ reduction with NaBH4 prior to catalytic dehydrogenation of AB produced highly dispersed and partially oxidized amorphous FeNi NPs stabilized by strong interaction with the CeO2 support by NiOCe and FeOCe bonding. Investigation of the influence of the Fe/Ni ratio revealed a volcano‐shaped relationship with a maximum at Fe/Ni=1. FeNi/CeO2 was further applicable to dehydrogenation from dimethylamine–borane ((CH3)2NHBH3). The advantages of this catalytic system, such as the facile preparation method, free of noble metals, and high recyclability, with easy recovery from the reaction mixture by application of an external magnet, are particularly desirable for a hydrogen vector in terms of potential industrial application in fuel cells.
Effect of Catalyst, Temperature, and Hydrogen Pressure on Slurry Hydrocracking Reactions of Naphthalene
Authors: Akmaz Solmaz , Caglayan Pegah Amiri
Published: April 2015

Hydrocracking reactions of naphthalene were investigated in a slurry‐type reactor with different catalyst compositions consisting of iron‐based compounds, metal oxides, and elementary sulfur in order to evaluate the most efficient catalyst composition. The reactions were repeated with the optimal catalyst composition at different H2 initial pressures, temperatures, and holding times to determine the influence of these parameters. At the end of each reaction, liquid samples were analyzed by gas chromatography and mass spectrometry. The most effective catalyst composition for hyrocracking reaction of naphthalene was found to be a mixture of FeSO4·H2O, Fe2O3, Al2O3, and sulfur. It can be concluded that hydrogenation, isomerization, cracking, and dealkylation take place during the hydrocracking reaction of naphthalene.
ChemInform Abstract: Exploring the Optoelectronic Structure and Thermoelectricity of Recent Photoconductive Chalcogenides Compounds, CsCdInQ3 (Q: Se, Te).
Authors: Khan Wilayat , Goumri‐Said Souraya
Published: April 2015

CsCdInQ3 (Q: Se, Te), potential materials for hard Xray and γ‐ray detection, are investigated by a DFT‐based full potential linearized augmented plane wave method.
ChemInform Abstract: Ba3P5N10Br:Eu2+: A Natural‐White‐Light Single Emitter with a Zeolite Structure Type.
Authors: Marchuk Alexey , Schnick Wolfgang
Published: April 2015

Ba3P5N10Br:Eu2+ (2 mol%) is prepared by high pressure solid state reaction using stoichiometric amounts of B(N3)2, BaBr2, P3N5, and EuCl2 (multi‐anvil press, 1‐5 GPa, 1000 °C, 30 min).
ChemInform Abstract: Sunlight Activated Long‐Lasting Luminescence from Ba5Si8O21: Eu2+, Dy3+ Phosphor.
Authors: Wang Pengjiu , Xu Xuhui , Zhou Dacheng , Yu Xue , Qiu Jianbei
Published: April 2015

The new title phosphor is prepared by solid state reaction of a stoichiometric mixture of BaCO3, SiO2, Eu2O3, and Dy2O3 (95% N2/5% H2, 1250 °C, 10 h).
ChemInform Abstract: Synthesis, Structural Characterization, and Physical Properties of the New Transition Metal Oxyselenide Ce2O2ZnSe2.
Authors: Ainsworth Chris M. , Wang Chun‐Hai , Tucker Matthew G. , Evans John S. O.
Published: April 2015

The title compound is prepared from powder mixtures of CeO2, Zn, and Se in a 1:2:1 ratio in an alumina crucible using Al placed in a different crucible as oxygen getter (1100—1225 °C, 1—24 h).
ChemInform Abstract: New Phase of MnSb2O6 Prepared by Ion Exchange: Structural, Magnetic, and Thermodynamic Properties.
Authors: Nalbandyan Vladimir B.
Published: April 2015

The new title phase is prepared from a mixture of NaSbO3, MnSO4, KCl, and KBr (CO2, 470 °C, 1 h) and characterized by powder XRD, magnetic, and thermophysical measurements, and DFT calculations.
ChemInform Abstract: The First 3‐Connected SrSi2‐Type 3D Chiral Framework Constructed from {Ni6PW9} Building Units.
Authors: Li Xin‐Xiong , Fang Wei‐Hui , Zhao Jun‐Wei , Yang Guo‐Yu
Published: April 2015

Prismatic crystals of [Ni(dap)2]3[WO4]3 [Ni6(dap)3 (OH)3PW9O34] 2·9H2O (dap: 1,2‐diaminopropane) are prepared by hydrothermal reaction of an aqueous solution of Ni(O‐Ac)2 and Na9[A‐α‐PW9O34] in the molar ratio of 1:0.13 to which dap is added dropwise under stirring (2 h) (autoclave, 170 °C, 3 d).
ChemInform Abstract: Base‐Switched Annuloselectivity in the Reactions of Ethyl Malonyl Chloride and Imines.
Authors: Yang Zhanhui , Li Siqi , Zhang Zhong , Xu Jiaxi
Published: April 2015

The reaction of imines (I) with ethyl malonyl chloride (II) in the presence of 2‐chloropyridine affords exclusively trans‐β‐lactams (III) via a [2+2] cycloaddition pathway, whilst the reaction in the presence of the strong nucleophilic base N‐methylimidazole affords dihydrooxazinones [cf.
ChemInform Abstract: Palladium(II) Complexes Bearing the 1,2,3‐Triazole Based Organosulfur/Selenium Ligand: Synthesis, Structure and Applications in Heck and Suzuki—Miyaura Coupling as a Catalyst via Palladium Nanoparticles.
Authors: Saleem Fariha , Rao G. K. , Kumar Arun , Kumar Satyendra , Singh Mahabir P. , Singh Ajai K.
Published: April 2015

The air and moisture insensitive palladium complexes PSL and PSEL efficiently catalyze the Heck and Suzuki—Miyaura coupling reaction of various aryl bromides including deactivated bromides with phenylboronic acid and butyl acrylate, respectively.
ChemInform Abstract: Facile Palladium‐Catalyzed Hydrocarboxylation of Olefins Without External CO Gas.
Authors: Wang Yang , Ren Wenlong , Li Jingfu , Wang Haining , Shi Yian
Published: April 2015

The facile protocol allows the hydrocarbonylation of olefins with phenyl formate and formic acid to afford carboxylic acids with high regioselectivity.
ChemInform Abstract: One‐Pot Synthesis of 1,2,4,5‐Tetrahydro‐2,4‐dioxobenzo[b][1,4]diazepine and Malonamide Derivatives Using Multi‐Component Reactions.
Authors: Rahmati Abbas , Ahmadi Samaneh , Ahmadi‐Varzaneh Mahdi
Published: April 2015

Multicomponent reaction of o‐phenylenediamine with arylidene malonitriles, isocyanides, and Meldrum′s acid provides diazepines (V) whereas 1,2‐diamines with electron‐withdrawing substituent as well as p‐phenylenediamine give malonamide derivatives.
ChemInform Abstract: Step‐Economy Etherification of Acylated Alcohols.
Authors: Xu Hua‐Dong , Xu Ke , Zheng Qing , He Wei‐Jie , Shen Mei‐Hua , Hu Wen‐Hao
Published: April 2015

The protocol succeeds for the etherification of acyclic and cyclic acylated alcohols, namely esters and lactones, using alkyl, alkenyl, and benzyl halogenides, but fails using tosylated alcohols.
ChemInform Abstract: Expedient Synthesis of Chiral α‐Amino Acids Through Nickel‐Catalyzed Reductive Cross‐Coupling.
Authors: Lu Xi , Yi Jun , Zhang Zhen‐Qi , Dai Jian‐Jun , Liu Jing‐Hui , Xiao Bin , Fu Yao , Liu Lei
Published: April 2015

The novel Ni‐catalyzed reductive coupling process allows the synthesis of a variety of non‐natural enantiopure α‐amino acids from serine or homoserine iodides with a range of different organic halides.
ChemInform Abstract: Direct Catalytic Addition of Alkylnitriles to Aldehydes by Transition‐Metal/NHC Complexes.
Authors: Sureshkumar Devarajulu , Ganesh Venkataraman , Kumagai Naoya , Shibasaki Masakatsu
Published: April 2015

Direct catalytic addition of alkylnitriles to aldehydes allows for an atom‐economical access to β‐hydroxynitriles under proton transfer conditions.
ChemInform Abstract: Synthesis of Aryl Azides from Aryl Halides Promoted by Cu2O/Tetraethylammonium Prolinate.
Authors: Hajipour Abdol R. , Mohammadsaleh Fatemeh
Published: April 2015

Compared to previously developed procedures the presented method offers the advantages of a fast reaction rate and the selective reaction of iodo over bromo substituted substrates.
ChemInform Abstract: Palladium‐Catalyzed Hydroxymethylation of Aryl‐ and Heteroarylboronic Acids Using Aqueous Formaldehyde.
Authors: Yamamoto Tetsuya , Zhumagazin Azamat , Furusawa Takuma , Tanaka Ryoji , Yamakawa Tetsu , Oe Yohei , Ohta Tetsuo
Published: April 2015

The applied catalyst is prepared in one step via C—H bond cleavage orthopalladation.
ChemInform Abstract: Synthesis of Novel Fluorescent Stilbenenitrones via a Mild, Ligand‐Free Heck‐Type Reaction of (E)‐[4‐(1,3‐Dioxolan‐2‐yl)styryl]trimethylsilane with Benzene Diazonium Tetrafluoroborate Derivatives.
Authors: Karbach Andre , Stemler Tobias , Kopp Christian , Trommer Wolfgang E.
Published: April 2015

The title reaction gives 4‐formylstilbenes (III) which are further reacted with N‐tert‐butylhydroxylamine hydrochloride to give target compounds (V).
ChemInform Abstract: Kinetic Resolution of Racemic Mandelic Acid Esters by N,N′‐Dioxide‐Scandium‐Complex‐Catalyzed Enantiomer‐Selective Acylation.
Authors: Zhang Yuheng , Liu Xiaohua , Zhou Lin , Wu Wangbin , Huang Tianyu , Liao Yuting , Lin Lili , Feng Xiaoming
Published: April 2015

A simple and efficient acylative kinetic resolution of racemic mandelic acid esters is accomplished with a chiral N,N‐dioxide‐scandium(III) complex under mild and base‐free reaction conditions.
ChemInform Abstract: Efficient and Simple Approaches Towards Direct Oxidative Esterification of Alcohols.
Authors: Ray Ritwika , Jana Rahul Dev , Bhadra Mayukh , Maiti Debabrata , Lahiri Goutam Kumar
Published: April 2015

A transition‐metal‐free oxidative cross‐coupling of two different alcohols is achieved using Oxone as oxidant and a mixture of TEMPO and Bu4NBr as catalysts.
ChemInform Abstract: Suzuki—Miyaura Reactions Promoted by a PdCl2/Sulfonate‐Tagged Phenanthroline Precatalyst in Water.
Authors: Li Qi , Zhang Li‐Ming , Bao Jia‐Jing , Li Hong‐Xi , Xie Jing‐Bo , Lang Jian‐Ping
Published: April 2015

A water soluble sulfonate‐functionalized phenanthroline‐type ligand is synthesized and successfully applied in the Pd‐catalyzed Sukuzi—Miyaura coupling of aryl bromides and iodides with arylboronic acids.
ChemInform Abstract: Copper‐Free Sonogashira Coupling Reaction Catalyzed by PVC‐Supported Triazine Palladium(II) Complex under Aerobic Conditions.
Authors: Bakherad Mohammad , Keivanloo Ali , Hadi Amene , Siavoshi Maesoume
Published: April 2015

A polyvinyl chloride supported triazine Pd(II)‐complex is developed and efficiently applied as heterogeneous recyclable catalyst for the Sonogashira coupling of aryl iodides and bromides.
ChemInform Abstract: Bifunctional Squaramide Catalysts with the Same Absolute Chirality for the Diastereodivergent Access to Densely Functionalized Cyclohexanes Through Enantioselective Domino Reactions. Synthesis and Mechanistic Studies.
Authors: Martinez Jose I. , Villar Laura , Uria Uxue , Carrillo Luisa , Reyes Efraim , Vicario Jose L.
Published: April 2015

A one‐pot approach for the title reactions is also presented [reaction of (VII)].
ChemInform Abstract: Palladium‐Catalyzed Annulation of Alkynes with ortho‐Halide‐Containing Benzyl Alcohols in Aqueous Medium.
Authors: Feng Jie , Lu Guoping , Lv Meifang , Cai Chun
Published: April 2015

Ortho‐brom benzyl alcohols are also applicable in these reactions with slightly lower yields.
ChemInform Abstract: Synthesis of Cycloalkanone‐Fused Cyclopropanes by Au(I)‐Catalyzed Oxidative Ene‐Yne Cyclizations.
Authors: Uetake Yuta , Niwa Takashi , Nakada Masahisa
Published: April 2015

The method is effectively applied to different substrate offering an alternative to previously developed procedures involving potentially explosive diazo compounds.
ChemInform Abstract: A Facile Approach to Spirocyclic 2‐Azido Indolines via Azidation of Indoles with Ceric Ammonium Nitrate.
Authors: Li Jing , Liu Mao , Li Qi , Tian Hua , Shi Yian
Published: April 2015

The oxidative azidation of indoles (I), (IV), and (VI) leads to desired spirocyclic 2‐azido indolines.
ChemInform Abstract: Catalytic Asymmetric Construction of 3,3′‐Spirooxindoles Fused with Seven‐Membered Rings by Enantioselective Tandem Reactions.
Authors: Wang Yang , Shi Feng , Yao Xi‐Xi , Sun Meng , Dong Liang , Tu Shu‐Jiang
Published: April 2015

The title species are prepared with high enantiopurity from isatins, 1,2‐phenylenediamines, and 1,3‐diketones in a single transformation.
ChemInform Abstract: Organocatalytic, Enantioselective, Intramolecular Oxa‐Michael Reaction of Alkoxyboronate: A New Strategy for Enantioenriched 1‐Substituted 1,3‐Dihydroisobenzofurans.
Authors: Ravindra Barnala , Das Braja Gopal , Ghorai Prasanta
Published: April 2015

The enantiomeric excess of the products may be further increased to <99% by recrystallization.
ChemInform Abstract: Synthesis of Highly Substituted N‐(Furan‐3‐ylmethylene)benzenesulfonamides by a Gold(I)‐Catalyzed Oxidation/1,2‐Alkynyl Migration/Cyclization Cascade.
Authors: Wang Tao , Huang Long , Shi Shuai , Rudolph Matthias , Hashmi A. Stephen K.
Published: April 2015

A rarely observed 1,2‐alkynyl migration occurs in the Au‐catalyzed cyclization of diynes to give tosylimine furans.
ChemInform Abstract: Diastereo‐ and Enantioselective Propargylation of Benzofuranones Catalyzed by Pybox‐Copper Complex.
Authors: Zhao Long , Huang Guanxin , Guo Beibei , Xu Lijun , Chen Jie , Cao Weiguo , Zhao Gang , Wu Xiaoyu
Published: April 2015

In addition to the propargylation of benzofuranones, this scalable method is also applicable to the corresponding transformation of indanone [cf.
ChemInform Abstract: Catalyst‐Free Synthesis of Trisubstituted Tetrahydrothiophenes in Water via a Cascade Sulfa‐Michael/Aldol (Henry) Type Reaction.
Authors: Song Jian , Moss Jamia , Yang Da‐Cheng , Guan Zhi , He Yan‐Hong
Published: April 2015

Title compounds are synthesized by a facile, highly atom‐efficient, and eco‐friendly procedure in excellent diastereoselectivities, in general.
ChemInform Abstract: Palladium Catalyzed Dual C—H Functionalization of Indoles with Cyclic Diaryliodoniums, an Approach to Ring Fused Carbazole Derivatives.
Authors: Wu Yongcheng , Peng Xiaopeng , Luo Bingling , Wu Fuhai , Liu Bo , Song Fenyun , Huang Peng , Wen Shijun
Published: April 2015

A series of dibenzocarbazoles is readily prepared by a Pd‐catalyzed cyclization of indoles with diaryliodoniumtriflates (II) via an intermolecular C2 arylation of indoles and a subsequent intramolecular C3 arylation.
ChemInform Abstract: Base‐Catalyzed Intramolecular Hydroamination of Cyclohexa‐2,5‐dienes: Insights into the Mechanism Through DFT Calculations and Application to the Total Synthesis of epi‐Elwesine.
Authors: Rousseau Geraldine , Lebeuf Raphael , Schenk Kurt , Castet Frederic , Robert Frederic , Landais Yannick
Published: April 2015

Different pyrrolidine regioisomers are obtained from the intramolecular hydroamination of dienes.
ChemInform Abstract: Substituent Enabled Divergent Synthesis of N‐Heterocycles: A Metal Carbene Approach Involving Intramolecular Carbene Interception.
Authors: Xu Hua‐Dong
Published: April 2015

The competitive intramolecular capture of a rhodium carbene generated in situ from carbene precursors 1‐sulfonyltriazoles allows a divergent synthesis of indoles or aza‐bicyclohexanes.
ChemInform Abstract: Phosphotungstic Acid as an Efficient Catalyst for Allylation of Isatins and N‐tert‐Butyloxycarbonylamido Sulfones under Solvent‐Free Conditions.
Authors: Ghosh Debashis , Saravanan S. , Gupta Naveen , Abdi Sayed H. R. , Khan Noor‐ul H. , Kureshy Rukhsana I. , Bajaj Hari C.
Published: April 2015

An efficient procedure for the allylation of less‐reactive isatins and N‐protected amido sulfones is developed using phosphotungstic acid as catalyst.
ChemInform Abstract: Novel and Thermally Stable Ionic Liquid (TBA Acetate) for Domino Reaction: Synthesis of Spirooxindoles via New Mechanistic Way.
Authors: Riyaz Sd , Indrasena A. , Naidu A. , Dubey P. K.
Published: April 2015

A simple, efficient and environmentally benign method for the three component, one‐pot synthesis of spirooxindoles using ionic liquid tetrabutylammonium acetate as an inexpensive catalyst as well as reaction medium.
ChemInform Abstract: Silanediol‐Catalyzed Carbon Dioxide Fixation.
Authors: Hardman‐Baldwin Andrea M. , Mattson Anita E.
Published: April 2015

Silanediol (DNSD) acts as an effective organocatalyst for the atom‐efficient conversion of epoxides to cyclic carbonates (III) under environmentally friendly conditions.
ChemInform Abstract: 1‐Butylimidazole‐Derived Ionic Liquids: Synthesis, Characterization and Evaluation of Their Antibacterial, Antifungal and Anticancer Activities.
Authors: Ranjan Prabodh , Kitawat Bheru Singh , Singh Man
Published: April 2015

Title compounds (III) are eco‐friendly synthesized in high yields and purities under solvent‐free conditions without the necessity of further purification.
ChemInform Abstract: Nickel‐Catalyzed Decarboxylative Arylation of Heteroarenes Through sp2 C—H Functionalization.
Authors: Yang Ke , Wang Peng , Zhang Cheng , Kadi Adnan A. , Fun Hoong‐Kun , Zhang Yan , Lu Hongjian
Published: April 2015

The direct decarboxylative arylation of hetereoarenes with benzoic acids through a nickel‐catalyzed sp2 C—H functionalization process is developed.
ChemInform Abstract: Cu(II)‐Mediated C—S/N—S Bond Formation via C—H Activation: Access to Benzoisothiazolones Using Elemental Sulfur.
Authors: Chen Fa‐Jie , Liao Gang , Li Xin , Wu Jun , Shi Bing‐Feng
Published: April 2015

The synthetic versatility of the products deriving from this scalable reaction is exemplified by numerous transformations of N‐protected benzoisothiazolone [cf.
ChemInform Abstract: Efficient Synthesis of 1,3,4‐Oxadiazoles Promoted by NH4Cl.
Authors: Gnanasekaran Krishna Kumar , Nammalwar Baskar , Murie Maeghan , Bunce Richard A.
Published: April 2015

The mild conditions tolerate various functional groups.
ChemInform Abstract: Simple Access to 5‐Carboalkoxy‐2,3‐dihydro‐4H‐pyran‐4‐ones via Domino Acylative Electrocyclization: The First Three Step Total Synthesis of the Dihydronaphthopyran‐4‐one Class of Natural Products.
Authors: Ilangovan Andivelu , Sakthivel Palaniappan
Published: April 2015

Optimum reaction conditions are examined for the CaCl2‐catalyzed synthesis of title compounds (III).
ChemInform Abstract: Benzylamine as an Arylcarboxy Surrogate: A Copper Catalyzed o‐Benzoxylation of 2‐Phenylpyridines Using Benzyl Amines.
Authors: Behera Ahalya , Rout Saroj K. , Guin Srimanta , Patel Bhisma K.
Published: April 2015

For the first time, benzylamine is used as a synthetic equivalent of an arylcarboxy group.
ChemInform Abstract: Rhodium(I)‐Catalyzed “ene‐Type” Cycloisomerization of N‐[2‐(2‐Alkyn‐1‐yl)phenyl]carbodiimides Leading to 3‐(cis‐Alken‐1‐yl)‐2‐aminoquinolines.
Authors: Otani Takashi , Onishi Misato , Seino Takafumi , Furukawa Naoki , Saito Takao
Published: April 2015

Title compounds such as (II), (IV), and (VI) are synthesized in high E‐selectivity.
ChemInform Abstract: New Synthetic Approach for the Preparation of 1‐Aryl‐3,4‐dihydroisoquinolines by Liebeskind—Srogl Reaction.
Authors: Abranyi‐Balogh Peter , Slegel Peter , Volk Balazs , Pongo Laszlo , Milen Matyas
Published: April 2015

The reaction tolerates diversely substituted aryl boronic acids except 2‐cyano and 2‐chlorophenyl boronic acids.
ChemInform Abstract: Diastereoselective Synthesis of Methanopyridoxazocinones.
Authors: Detistov Oleksandr S. , Panda Siva S. , Steel Peter J. , Asiri Abdullah M. , Hall C. Dennis , Katritzky Alan R.
Published: April 2015

Two different approaches to the title compounds are elaborated using either substituted 7‐azacoumarins, enolizable ketones and primary amines [cf.
ChemInform Abstract: Construction of Axial Chirality by Rhodium‐Catalyzed Asymmetric Dehydrogenative Heck Coupling of Biaryl Compounds with Alkenes.
Authors: Zheng Jun , You Shu‐Li
Published: April 2015

A variety of biaryl compounds with benzo[h]isoquinolinyl moieties is alkenylated via Heck coupling with high regio‐ and enantioselectivity.
ChemInform Abstract: Electrogenerated Base‐Promoted Synthesis of 5‐Aryl‐5,6‐dihydro‐2H‐pyrano[2,3‐d]pyrimidine‐2,4,7‐triones by Multicomponent Assembly of Barbituric Acid, Aldehydes and Meldrum′s Acid at Room Temperature.
Authors: Veisi Hojat , Maleki Abbas , Omrani Zahra , Lotfi Shahram
Published: April 2015

An electrochemical procedure is presented to synthesize the title compounds (IV) by a three‐component one‐pot reaction of aromatic aldehydes, Meldrum′s acid and barbituric acid.
ChemInform Abstract: C—N and C—P Bond Formation via Cross Dehydrative Coupling Reaction: An Efficient Synthesis of Novel 3,4‐Dihydroquinazolines.
Authors: Saidulu G. , Kumar R. Arun , Anitha T. , Srinivasulu A. , Sridhar B. , Liu Shiuh Tzung , Reddy K. Rajender
Published: April 2015

Structurally diverse C‐4‐amidyl‐ and C‐4‐phosphonyl‐3,4‐dihydroquinazoline derivatives (III)/(V) are efficiently obtained via dehydrative cross‐coupling reaction utilizing either an inexpensive iron catalyst or metal‐free conditions.
ChemInform Abstract: A Catalytic Diastereoselective Formal [5 + 2] Cycloaddition Approach to Azepino[1,2‐a]indoles: Putative Donor‐Acceptor Cyclobutanes as Reactive Intermediates.
Authors: Shenje Raynold , Martin M. Cynthia , France Stefan
Published: April 2015

Alkyl‐substituted terminal double bonds [e.
ChemInform Abstract: An Efficient Synthesis of Benzodiazepine Derivatives via a One‐Pot, Three‐Component Reaction Accelerated by a Chitosan‐Supported Superparamagnetic Iron Oxide Nanocomposite.
Authors: Maleki Ali , Kamalzare Maryam
Published: April 2015

The catalyst utilized in this green procedure is recycled and reused in four additional cycles without loss of its activity.
ChemInform Abstract: Diversity‐Oriented Synthesis of Drug‐Like Macrocyclic Scaffolds Using an Orthogonal Organo‐ and Metal Catalysis Strategy.
Authors: Grossmann Andre , Bartlett Sean , Janecek Matej , Hodgkinson James T. , Spring David R.
Published: April 2015

Key features of the strategy are NHC‐mediated organocoupling and Grubbs‐catalyzed metathesis reaction.
ChemInform Abstract: Silver‐Promoted Oxidative Cyclization of 1,6‐Enynes: Highly Regioselective Synthesis of Phosphorated Fluorene Derivatives.
Authors: Zhou Zhao‐Zhao , Jin Dong‐Po , Li Lian‐Hua , He Yu‐Tao , Zhou Ping‐Xin , Yan Xiao‐Biao , Liu Xue‐Yuan , Liang Yong‐Min
Published: April 2015

The reduction of the pentavalent phosphine in the products to a trivalent one is demonstrated for one product (XII).
ChemInform Abstract: Rhenium‐Catalyzed Synthesis of 2H‐1,2‐Oxaphosphorin 2‐Oxides via the Regio‐ and Stereoselective Addition Reaction of β‐Keto Phosphonates with Alkynes.
Authors: Murai Masahito , Nakamura Masahiro , Takai Kazuhiko
Published: April 2015

β‐Ketophosphonates undergo a regio‐ and stereoselective insertion reaction with alkynes to form δ‐phosphonyl‐α,β‐unsaturated ketone intermediates which are cyclized to form the title compounds (III) and (V) in moderate yields.
ChemInform Abstract: Briarenolide J, the First 12‐Chlorobriarane Diterpenoid from an Octocoral Briareum sp. (Briareidae).
Authors: Sheu Jyh‐Horng
Published: April 2015

This novel compound exhibits inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
ChemInform Abstract: Lupane‐Triterpenoids from Stem Bark of Dillenia indica.
Authors: Ghosh Partha Sarathi , Sarma Indrajit Sil , Sato Noriko , Harigaya Yoshihiro , Dinda Biswanath
Published: April 2015

A new lupane‐triterpene acid ester, dillenic acid (I), is isolated along with four known compounds from the stem bark of Dillenia indica Linn (Dilleniaceae).
ChemInform Abstract: Phase‐Transfer‐Catalyzed Asymmetric SNAr Reaction of α‐Amino Acid Derivatives with Arene Chromium Complexes.
Authors: Shirakawa Seiji , Yamamoto Kenichiro , Maruoka Keiji
Published: April 2015

This method overcomes the limitations of previous phase‐transfer‐catalyzed asymmetric α‐arylations of carbonyl compounds, which were limited to arenes with strong electron‐withdrawing substituents as electrophiles.
ChemInform Abstract: Synthesis of Bis‐α‐amino Acids Through Proline Catalyzed Asymmetric α‐Amination of Higher Homologues of Garner′s Aldehyde.
Authors: Petakamsetty Ramu , Das Ram Pada , Ramapanicker Ramesh
Published: April 2015

The convenient synthesis of bis‐α‐amino acid esters involves the proline catalyzed highly diastereoselective α‐hydrazination of aldehydes (I) with dibenzyl azodicarboxylate as the key step.
ChemInform Abstract: New Isoquinoline Alkaloids from the Stem Bark of Berberis aristata.
Authors: Ahamad Javed , Naquvi Kamran J. , Ali Mohd , Mir Showkat R.
Published: April 2015

isolation of three new isoquinoline alkaloids, berberine phenoxide (I), ketoberberine benzoate A (II), and ketoberberine benzoate B (III)/
ChemInform Abstract: Ion Exchange in Hydroxyapatite with Lanthanides.
Authors: Cawthray Jacqueline F. , Creagh A. Louise , Haynes Charles A. , Orvig Chris
Published: April 2015

The thermodynamics of ion exchange in hydroxyapatite (Ca5(PO4)3(OH)) with La3+, Sm3+, Gd3+, Ho3+, Yb3+, and Lu3+ is investigated by isothermal titration calorimetry.
ChemInform Abstract: Nanoscale Metal Fluorides: A New Class of Heterogeneous Catalysts
Authors: Kemnitz Erhard
Published: April 2015

Review: 167 refs.
ChemInform Abstract: Phosphorus Rich d10 Ion Polyphosphides and Selected Materials
Authors: Bawohl Melanie , Nilges Tom
Published: April 2015

Review: [69 refs.
ChemInform Abstract: Porous Organic Molecular Cages: From Preparation to Applications
Authors: Xiong Ming , Ding Huimin , Li Bijian , Zhou Tailin , Wang Cheng
Published: April 2015

Review: 73 refs.
ChemInform Abstract: Catalysis Gold Unleashes the Power of Three
Authors: Kourra Christopher M. B. K. , Cramer Nicolai
Published: April 2015

Review: 9 refs.
ChemInform Abstract: Application of Dimethyl N‐Cyanodithioiminocarbonate in Synthesis of Fused Heterocycles and in Biological Chemistry
Authors: Elgemeie Galal H. , Mohamed Reham A.
Published: April 2015

Review: 115 refs.
ChemInform Abstract: Nickel N‐Heterocyclic Carbene‐Catalyzed C—C Bond Formation: Reactions and Mechanistic Aspects
Authors: Henrion Mickael , Ritleng Vincent , Chetcuti Michael J.
Published: April 2015

Review: 165 refs.
ChemInform Abstract: Experimental and Theoretical Perspectives of the Noyori‐Ikariya Asymmetric Transfer Hydrogenation of Imines
Authors: Vaclavik Jiri , Sot Petr , Pechacek Jan , Vilhanova Beata , Matuska Ondrej , Kuzma Marek , Kacer Petr
Published: April 2015

Review: 87 refs.
ChemInform Abstract: The Calixarene P‐Bromodienone Route: From a Chemical Curiosity to an Useful Synthetic Tool
Authors: Gaeta Carmine , Talotta Carmen , Neri Placido
Published: April 2015

Review: 227 refs.
ChemInform Abstract: Catalytic Asymmetric Transfer Hydrogenation: An Industrial Perspective
Authors: Cotarca Livius , Verzini Massimo , Volpicelli Raffaella
Published: April 2015

Review: 54 refs.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative Coupling and C‐H Activation
Authors: Wu Xiao‐Feng , Barnard Christopher F. J.
Published: April 2015

Review: 181 refs.
ChemInform Abstract: Propargylic Sulfides: Synthesis, Properties, and Application
Authors: Vizer Svetlana A. , Sycheva Elena S. , Al Quntar Abed Al Aziz , Kurmankulov Nurzhan B. , Yerzhanov Kazbek B. , Dembitsky Valery M.
Published: April 2015

Review: 333 refs.
ChemInform Abstract: Enantioselective Henry Reaction Catalyzed By Supported Transition Metal Complexes
Authors: Drabina Pavel , Harmand Lydie , Sedlak Milos
Published: April 2015

Review: 45 refs.
ChemInform Abstract: Metal Catalysts. Applications in Higher‐Membered N‐Heterocycles Synthesis
Authors: Kaur Navjeet
Published: April 2015

Review: 158 refs.
ChemInform Abstract: Sulfonic Acid‐Functionalized Mesoporous Silica (SBA‐Pr‐SO3H) as Solid Acid Catalyst in Organic Reactions
Authors: Mohammadi Ziarani Ghodsi , Lashgari Negar , Badiei Alireza
Published: April 2015

Review: 251 refs.
ChemInform Abstract: From α‐Nucleophiles to Functionalized Aggregates: Exploring the Reactivity of Hydroxamate Ion Towards Esterolytic Reactions in Micelles
Authors: Singh Namrata , Karpichev Yevgen , Sharma Rahul , Gupta Bhanushree , Sahu Arvind K. , Satnami Manmohan L. , Ghosh Kallol K.
Published: April 2015

Review: [98 refs.
ChemInform Abstract: Catalytic Nucleic Acids (DNAzymes) as Functional Units for Logic Gates and Computing Circuits: From Basic Principles to Practical Applications
Authors: Orbach Ron , Willner Bilha , Willner Itamar
Published: April 2015

Review: [41 refs.
ChemInform Abstract: Metallic Nanocatalysis: An Accelerating Seamless Integration with Nanotechnology
Authors: Dai Yihu , Wang Ye , Liu Bin , Yang Yanhui
Published: April 2015

Review: 188 refs.
ChemInform Abstract: Fluorescent Adenosine Analogues: A Comprehensive Survey
Authors: Matarazzo Augusto , Hudson Robert H. E.
Published: April 2015

Review: 76 refs.
ChemInform Abstract: Recent Developments in Solar H2 Generation from Water Splitting
Authors: Rajaambal Sivaraman , Sivaranjani Kumarsrinivasan , Gopinath Chinnakonda S.
Published: April 2015

Review: 75 refs.
ChemInform Abstract: Functional Polysaccharides from Medicinal Mushroom Cordyceps sinensis as a Potent Food Supplement: Extraction, Characterization and Therapeutic Potentials — A Systematic Review
Authors: Shashidhar G. M. , Giridhar P. , Manohar B.
Published: April 2015

Review: 133 refs.
ChemInform Abstract: Spectroscopic Studies of Keto—Enol Tautomeric Equilibrium of Azo Dyes
Authors: Rauf M. A. , Hisaindee S. , Saleh N.
Published: April 2015

Review: 36 refs.
Energy‐efficient CPU frequency control for the Linux system
Authors: Karpowicz Michał P.
Published: April 2015

Efficiency of energy usage in computing systems improves, however, still not at the rate matching the climbing demand for computing capacity. To address this urging problem, computing elements of the latest generation, that is, CPUs/graphics processing units, memory units, and network interface cards, have been designed to operate in multiple modes with differentiated energy consumption levels. Mode switching and high‐frequency performance monitoring functions have also been exposed by co‐designed abstract programming interfaces. The challenge of energy‐efficient computing is to develop hardware control mechanisms taking advantage of the new capabilities. This paper aims at giving an insight into the structure of optimal energy‐aware CPU frequency scaling rules. It gives a characterization of solutions to the optimal control problem of energy‐efficient real‐time packet inspection performed by a Linux server. A class of CPU frequency switching rules, exploiting dynamic voltage and frequency scaling mechanisms, is constructed based on experimentally identified model of server operations. The control rules are demonstrated to outperform the default CPU frequency scaling governor for the Linux kernel, both in terms of achievable power savings and service quality. Copyright © 2015 John Wiley & Sons, Ltd.
Protic Salts of High Nitrogen Content as Versatile Precursors for Graphitic Carbon Nitride: Anion Effect on the Structure, Properties, and Photocatalytic Activity
Authors: Zhang Yan , Zhao Huifang , Hu Zhijun , Chen Hua , Zhang Xuejin , Huang Qi , Wo Qizhong , Zhang Shiguo
Published: April 2015

Graphitic carbon nitride (g‐C3N4) is traditionally obtained by thermal polycondensation of nitrogen‐rich organic nonionic precursors. Herein, we provide a new and simple strategy for the synthesis of g‐C3N4 through direct thermal condensation of single protic guanidine salts with various anions. The thermal condensation process, and the structure and photophysical properties (optical properties, thermal stabilities, morphology and porosity, and photocatalytic activity) of the obtained g‐C3N4 materials are investigated intensively through thermogravimetric analysis, powder X‐ray diffraction, X‐ray photoelectron spectroscopy, UV/Vis diffuse reflectance spectroscopy, nitrogen adsorption isotherms, and photodegradation of Rhodamine B. The results reveal that during thermal condensation, the nitrogen‐rich basic core in the guanidine salts serves as a carbon and nitrogen source to form the skeleton of g‐C3N4, and the counter anions mediate the thermal condensation in situ and modify slightly the structure and properties of g‐C3N4, even though they are not incorporated into the final structure. Among all g‐C3N4 materials, including the pristine g‐C3N4 from melamine, the g‐C3N4 derived from guanidine thiocyanate exhibits a high activity toward the photocatalytic degradation of Rhodamine B dye because of its relatively high surface area, enhanced absorption, small bandgap, and low photoluminescence intensity.
Hydrogen Bonding and Anticancer Properties of Water‐Soluble Chiral p‐Cymene RuII Compounds with Amino‐Oxime Ligands
Authors: Benabdelouahab Yosra , Muñoz‐Moreno Laura , Frik Malgorzata , de la Cueva‐Alique Isabel , El Amrani Mohammed Amin , Contel María , Bajo Ana M. , Cuenca Tomás , Royo Eva
Published: April 2015

An investigation into the effects of hydrogen bonding on the aggregation tendency of ruthenium compounds [(η6‐p‐cymene)Ru(κNHR,κNOH)Cl]Cl {R = Ph (1a), Bn (1b)} and [(η6‐p‐cymene)Ru(κ2NH(2‐pic),κNOH)][PF6]2 (1c), [(η6‐p‐cymene)Ru(κNHBn,κNO)Cl] (2b), and [(η6‐p‐cymene)Ru(κNBn,κ2NO)] (3b) has been performed by means of concentration‐dependence 1H NMR chemical shift and DOSY experiments. The synthesis and full characterization of new compounds 1c, [(η6‐p‐cymene)Ru(κNPh,κ2NO)] (3a) and 3b are also reported. The effect of the water‐soluble ruthenium complexes 1a–c on cytotoxicity, cell adhesion, and cell migration of the androgen‐independent prostate cancer PC3 cells have been assessed by MTT, adhesion to type‐I‐collagen, and recovery of monolayer wounds assays, respectively. Interactions of 1a–c with DNA and human serum albumin have also been studied. Together, the properties reported herein suggest that ruthenium compounds 1a–c have considerable potential as anticancer agents against advanced prostate cancer.
Presence of hyperalgesia predicts analgesic efficacy of topically applied capsaicin 8% in patients with peripheral neuropathic pain
Authors: Mainka T. , Malewicz N.M. , Baron R. , Enax‐Krumova E.K. , Treede R.‐D. , Maier C.
Published: April 2015

Background

Topical high‐dose capsaicin acting on TRPV1 receptors and inducing an intraepidermal decrease in the small nerve fibre count is effective in treating neuropathic pain (NP). Sensory changes after capsaicin application, their correlation with pain relief and their role as possible predictors of response have been insufficiently analysed. We hypothesized a positive correlation between pain relief and increase in the warmth detection threshold (WDT), indicating loss of C‐fibre function, and higher response rates in patients with preserved C‐fibre function or heat hyperalgesia before application.

Methods

Quantitative Sensory Testing (DFNS protocol) was conducted in 20 unilaterally treated patients with peripheral NP (peripheral nerve injury: n = 14, polyneuropathy: n = 4, postherpetic neuralgia: n = 2) before and 2, 4, 6 and 8 weeks after application of capsaicin (8%) in this open‐label study. Response was defined as ≥30% or ≥2 (Numeric Rating Scale: 0–10) decrease of current pain at any follow‐up compared to baseline.

Results

In all patients, WDT significantly increased 8 weeks after capsaicin application, but did not correlate with pain relief in responders (n = 10, r = 0.179, p = 0.141). Before treatment, responders showed significantly higher z‐values for the cold (CPT, +0.7 ± 1.1 vs. −0.4 ± 0.9) and mechanical pain threshold (MPT; 0.7 ± 2.5 vs. −1.2 ± 1.3), but did not differ from non‐responders regarding WDT or heat pain threshold. A sum of the z‐values for CPT and MPT >0.8 before treatment identified responders with 100% specificity and 70% sensitivity.

Conclusions

Efficacy of capsaicin does not correlate with the induced loss of function of small fibres, measured by QST. Presence of cold and pinprick hyperalgesia seems to be predictive of response to capsaicin (8%).
Salinity and dissolved organic carbon both affect copper toxicity in mussel larvae: Copper speciation or competition cannot explain everything
Authors: Deruytter David , Vandegehuchte Michiel B. , Garrevoet Jan , De Laender Frederik , Vergucht Eva , Delbeke Katrien , Blust Ronny , De Schamphelaere Karel A.C. , Vincze Laszlo , Janssen Colin R.
Published: April 2015

Predicting copper (Cu) toxicity in marine and estuarine environments is challenging because of the influence of anions on Cu speciation, competition between Cu2+ and other cations at the biotic ligand and the effect of salinity on the physiology of the organism. In the present study the combined effect of salinity and dissolved organic carbon (DOC) on Cu toxicity to larvae of Mytilus galloprovincialis was assessed. Two statistical models were developed and used to elucidate the relationship between Cu toxicity, salinity, and DOC. All models based on dissolved Cu indicate a decrease in Cu toxicity with increasing DOC concentrations, which can partly be explained by complexation of Cu2+ ions with DOC. These models also indicate an increase in Cu toxicity (modeled with dissolved Cu or Cu2+ activity) with increasing salinity, suggesting a salinity-induced alteration in the physiology of the mussel larvae. When based on Cu body burdens, neither of the models indicates an effect of salinity or DOC. This shows that the Cu body burden is a more constant predictor of Cu toxicity, regardless of the water chemistry influencing Cu speciation or competition and possible physiological alterations or changes in Cu speciation or competition. Environ Toxicol Chem 2015;34:1330–1336. © 2015 SETAC
Hohe Energiedichte
Authors: Unterstell Rembert
Published: April 2015

Volker Presser erforscht und entwickelt funktionelle Nanomaterialien für elektrochemische Anwendungen. Mit ihnen will der Heinz Maier‐Leibnitz‐Preisträger alternative Energiespeicher leistungsfähiger und nachhaltiger machen.
Ein ganz besonderer Preis
Authors: Strohschneider Peter
Published: April 2015

Seit drei Jahrzehnten die wichtigste Auszeichnung für Forscherinnen und Forscher in Deutschland: Das Leibniz‐Programm der DFG hat die gesamte Wissenschaft hierzulande vielfältig geprägt. Sein Jubiläum ist Grund zum Feiern, aber auch zum Nachdenken über die nächsten 30 Jahre.
Effect of storage on the chemical composition, microbiological load, and sensory properties of cassava starch‐based custard powder
Authors: Awoyale Wasiu , Sanni Lateef O. , Shittu Taofik A. , Adegunwa Mojisola O.
Published: April 2015

The effect of storage on the chemical, microbiological, and sensory properties of cassava starch‐based custard powder (CbCP) blends as mixture of yellow‐fleshed cassava root starch (YfCRS) (90–98%) and whole egg powder (WEP) (2–10%) was investigated. These were prepared using central composite rotatable design, and separately packaged in polyvinyl chloride plastic can and stored in storage box (30 ± 2°C). The chemical and microbiological analyses of the stored CbCP were evaluated at 3 weeks intervals, while the sensory property was determined at 6 weeks interval for 24 weeks. The result showed that the protein, fat, and the total‐β‐carotene contents of the CbCP decreased significantly (P ≤ 0.001) after storage while moisture content and microbiological load increased. All the CbCP sensory attributes were accepted at the end of storage, except taste and color. The CbCP gruel prepared from 94% YfCRS: 0.34% WEP and 90% YfCRS: 2% WEP blends were the most acceptable after storage.
MRTF‐A and STAT3 promote MDA‐MB‐231 cell migration via hypermethylating BRSM1
Authors: Xing Wen‐Jing , Liao Xing‐Hua , Wang Nan , Zhao Dong‐Wei , Zheng Li , Zheng De‐Liang , Dong Jian , Zhang Tong‐Cun
Published: April 2015

Breast cancer is the leading cause of cancer death in women worldwide which is closely related to metastasis. But the exact molecular mechanism of metastasis is still not fully understood. We now report that both MRTF‐A and STAT3 play important roles in migration of MDA‐MB‐231 breast cancer cells. Moreover, MRTF‐A and STAT3 synergistically increased MDA‐MB‐231 cell migration by promoting the expression of migration markers urokinase‐type plasminogen activator (uPA) and osteopontin (OPN) and inhibiting the expression of breast cancer metastasis suppressor 1 (BRMS1). Luciferase reporter assays demonstrated that MRTF‐A and STAT3 do not affect transcription of the BRMS1 promoter. Instead, we identified a newly molecular mechanism by which MRTF‐A and STAT3 synergistically controlled MDA‐MB‐231 cell migration by recruiting DNMT1 to hypermethylate the promoter of BRMS1 and thus affect the expression of BRMS1. Interestingly, physical interaction between MRTF‐A and STAT3 synergistically promotes the transactivity of DNMT1 by binding to the GAS element within the DNMT1 promoter. Our data thus provide important and novel insights into the roles of MRTF‐A and STAT3 in regulating MDA‐MB‐231 cell migration. © 2015 IUBMB Life, 67(3):202–217, 2015