bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 1 from EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor
Authors: Jia Yong , Juarez Jose , Li Jie , Manuia Mari , Niederst Matthew J. , Tompkins Celin , Timple Noelito , Vaillancourt Mei-Ting , Pferdekamper AnneMarie Culazzo , Lockerman Elizabeth L. , Li Chun , Anderson Jennifer , Costa Carlotta , Liao Debbie , Murphy Eric , DiDonato Michael , Bursulaya Badry , Lelais Gerald , Barretina Jordi , McNeill Matthew , Epple Robert , Marsilje Thomas H. , Pathan Nuzhat , Engelman Jeffrey A. , Michellys Pierre-Yves , McNamara Peter , Harris Jennifer , Bender Steven , Kasibhatla Shailaja
Published: March 2023

This file contains the supplementary Table S1 that describes the characteristics and anti-proliferative activities of EGF816 on a number of patient-derived cell lines
Supplementary Figure S1 from Small-Molecule Prodigiosin Restores p53 Tumor Suppressor Activity in Chemoresistant Colorectal Cancer Stem Cells via c-Jun-Mediated ΔNp73 Inhibition and p73 Activation
Authors: Prabhu Varun V. , Hong Bo , Allen Joshua E. , Zhang Shengliang , Lulla Amriti R. , Dicker David T. , El-Deiry Wafik S.
Published: March 2023

Prodigiosin targets CRCSC self-renewal in vitro.
Supplementary Figures 1 through 5 from EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor
Authors: Jia Yong , Juarez Jose , Li Jie , Manuia Mari , Niederst Matthew J. , Tompkins Celin , Timple Noelito , Vaillancourt Mei-Ting , Pferdekamper AnneMarie Culazzo , Lockerman Elizabeth L. , Li Chun , Anderson Jennifer , Costa Carlotta , Liao Debbie , Murphy Eric , DiDonato Michael , Bursulaya Badry , Lelais Gerald , Barretina Jordi , McNeill Matthew , Epple Robert , Marsilje Thomas H. , Pathan Nuzhat , Engelman Jeffrey A. , Michellys Pierre-Yves , McNamara Peter , Harris Jennifer , Bender Steven , Kasibhatla Shailaja
Published: March 2023

This file shows the Supplementary figures. Figure S1 shows the chemical structure of EGF816 and its binding to EGFR T790M mutant. Figure S2 shows the tolerability of EGF816 in the in vivo xenograft models. Figure S3 shows the in vivo PK and PD after a single dose of EGF816. Figure S4 shows the selectivity profile of EGF816 in the kinome tree. Figure S5 shows the morphology of EGF816 resistance clones.
Supplementary Figure 5 from SIGMAR1 Regulates Membrane Electrical Activity in Response to Extracellular Matrix Stimulation to Drive Cancer Cell Invasiveness
Authors: Crottès David , Rapetti-Mauss Raphael , Alcaraz-Perez Francisca , Tichet Mélanie , Gariano Giuseppina , Martial Sonia , Guizouarn Hélène , Pellissier Bernard , Loubat Agnès , Popa Alexandra , Paquet Agnès , Presta Marco , Tartare-Deckert Sophie , Cayuela Maria Luisa , Martin Patrick , Borgese Franck , Soriani Olivier
Published: March 2023

Sig1R promotes hERG- and AKT-dependent FDM-induced cell spreading, VEGF secretion and endothelial transmigration
Supplementary Figure 2 from SIGMAR1 Regulates Membrane Electrical Activity in Response to Extracellular Matrix Stimulation to Drive Cancer Cell Invasiveness
Authors: Crottès David , Rapetti-Mauss Raphael , Alcaraz-Perez Francisca , Tichet Mélanie , Gariano Giuseppina , Martial Sonia , Guizouarn Hélène , Pellissier Bernard , Loubat Agnès , Popa Alexandra , Paquet Agnès , Presta Marco , Tartare-Deckert Sophie , Cayuela Maria Luisa , Martin Patrick , Borgese Franck , Soriani Olivier
Published: March 2023

Sig1R is associated to β1 integrin and promotes β1 integrin / hERG association without altering β1 integrin membrane expression
Supplementary Figure 2 from A Small-Molecule Antagonist of the β-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis
Authors: Fang Liang , Zhu Qionghua , Neuenschwander Martin , Specker Edgar , Wulf-Goldenberg Annika , Weis William I. , von Kries Jens P. , Birchmeier Walter
Published: March 2023

Fig. S2 Specific inhibition of Wnt signaling by LF3.
Supplementary Table S1 from Loss of TGFβ Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance
Authors: Busch Susann , Sims Andrew H. , Stål Olle , Fernö Mårten , Landberg Göran
Published: March 2023

Multivariate analysis of recurrence-free survival regarding prognostic information of TGFBR2.
Supplementary Figure S5 from Loss of TGFβ Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance
Authors: Busch Susann , Sims Andrew H. , Stål Olle , Fernö Mårten , Landberg Göran
Published: March 2023

TGFβ and ERα transcriptional activity.
Supplemental Figures 1 through 5 from Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy
Authors: Pilon-Thomas Shari , Kodumudi Krithika N. , El-Kenawi Asmaa E. , Russell Shonagh , Weber Amy M. , Luddy Kimberly , Damaghi Mehdi , Wojtkowiak Jonathan W. , Mulé James J. , Ibrahim-Hashim Arig , Gillies Robert J.
Published: March 2023

Supplemental Figure S1: Inhibition of PI3 kinase signaling leads to loss of T cell function. Activated T cells were cultured at pH 6.6 or 7.4 for 24h in presence or absence of the PI3K Supplemental Figure S2: OT-1 T cell metabolism. OT-1 T cells were cultured with OVASIINFEKL peptide for 48 hours at either pH 6.6 or 7.4. Cells were subsequently metabolically profiled using a Seahorse XF-96 analyzer. Supplemental Figure S3: Knocking out the acid sensor, TDAG8, does not rescue IFN-gamma production by T cells. T cells were isolated from TDAG8 k/o or wild-type (WT) mice and stimulated in the presence of 10 ug/ml plate-bound anti-CD3 antibodies for 48 hours at pH 6.6 or 7.4. Supernatants were collected and IFN-gamma was measured by ELISA. Supplemental Figure S4: Representative B16 tumors in mice treated with anti-CTLA4 antibodies with or without buffer therapy. Supplemental Figure S5: Buffer therapy has little effect on systemic T cell activity in B16- bearing mice treated with anti-PD-1 antibody. inhibitor BEZ-235.
Supplementary Methods from Balancing Protein Stability and Activity in Cancer: A New Approach for Identifying Driver Mutations Affecting CBL Ubiquitin Ligase Activation
Authors: Li Minghui , Kales Stephen C. , Ma Ke , Shoemaker Benjamin A. , Crespo-Barreto Juan , Cangelosi Andrew L. , Lipkowitz Stanley , Panchenko Anna R.
Published: March 2023

Detailed description of methods for computational modeling and analysis.
Supplementary Table S1 from Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis
Authors: Guo Yabin , Updegraff Barrett L. , Park Sunho , Durakoglugil Deniz , Cruz Victoria H. , Maddux Sarah , Hwang Tae Hyun , O'Donnell Kathryn A.
Published: March 2023

CIS gene orthologues that are altered in AML.
Supplementary Table S4 from MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development
Authors: Eso Yuji , Takai Atsushi , Matsumoto Tomonori , Inuzuka Tadashi , Horie Takahiro , Ono Koh , Uemoto Shinji , Lee Kyeryoung , Edelmann Winfried , Chiba Tsutomu , Marusawa Hiroyuki
Published: March 2023

List of somatic mutations in HCC tissues of each mouse type detected by whole-exome sequencing
Supplementary Figure 8 from Antagonizing Integrin β3 Increases Immunosuppression in Cancer
Authors: Su Xinming , Esser Alison K. , Amend Sarah R. , Xiang Jingyu , Xu Yalin , Ross Michael H. , Fox Gregory C. , Kobayashi Takayuki , Steri Veronica , Roomp Kirsten , Fontana Francesca , Hurchla Michelle A. , Knolhoff Brett L. , Meyer Melissa A. , Morgan Elizabeth A. , Tomasson Julia C. , Novack Joshua S. , Zou Wei , Faccio Roberta , Novack Deborah V. , Robinson Stephen D. , Teitelbaum Steven L. , DeNardo David G. , Schneider Jochen G. , Weilbaecher Katherine N.
Published: March 2023

Anti-CSF1 treatment on β3KOM mice
Supplemental Tables, Figures and Figure Legends from The Beta Subunit of Hemoglobin (HBB2/HBB) Suppresses Neuroblastoma Growth and Metastasis
Authors: Maman Shelly , Sagi-Assif Orit , Yuan Weirong , Ginat Ravit , Meshel Tsipi , Zubrilov Inna , Keisari Yona , Lu Weiyue , Lu Wuyuan , Witz Isaac P.
Published: March 2023

This file includes tables presenting quantitative Real-Time PCR oligonucleotide primers and chemically synthesized peptide segments of human HBB. It also contains figures presenting the influence of separated lung-derived factors on neuroblastoma cell viability, the beta subunit of hemoglobin is elevated in micrometastasis-bearing organs of inoculated mice, single channel confocal images of HBB2 expression in alveolar epithelial and endothelial cells, a high expression of HBB2 is seen in alveolar endothelial cells lining blood vessels of varied diameters in micrometastasis-bearing mice, the beta subunit isolated from native human hemoglobin inhibits neuroblastoma cell viability, human HBB and its derivative peptide Metox do not mediate hemolysis of red blood cells, an intravenous or intranasal treatment of Metox inhibits neuroblastoma local tumor growth and metastasis, and nitric oxide is not influenced by high HBB2 levels in the lungs and serum of micrometastasis-bearing mice.
Supplementary Figure 1 from Antagonizing Integrin β3 Increases Immunosuppression in Cancer
Authors: Su Xinming , Esser Alison K. , Amend Sarah R. , Xiang Jingyu , Xu Yalin , Ross Michael H. , Fox Gregory C. , Kobayashi Takayuki , Steri Veronica , Roomp Kirsten , Fontana Francesca , Hurchla Michelle A. , Knolhoff Brett L. , Meyer Melissa A. , Morgan Elizabeth A. , Tomasson Julia C. , Novack Joshua S. , Zou Wei , Faccio Roberta , Novack Deborah V. , Robinson Stephen D. , Teitelbaum Steven L. , DeNardo David G. , Schneider Jochen G. , Weilbaecher Katherine N.
Published: March 2023

Blood vessel density analysis of tumor tissue
Supplementary Figures S1-S5 from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
Authors: Boutet Marie , Gauthier Ludiane , Leclerc Marine , Gros Gwendoline , de Montpreville Vincent , Théret Nathalie , Donnadieu Emmanuel , Mami-Chouaib Fathia
Published: March 2023

Effects of chemokines and TGF-B on T-cell adhesion to recombinant molecules and specific tumor cells (S1); Influence of TGF-B and chemokines on integrin expression and T-cell motility (S2); Tumor slice staining, influence of anti-CD103 on calcium response and ILK phosphorylation and effect of TGF-B and chemical inhibitors on ILK expression and T-cell adhesion (S3); Influence of siRNA-E-cadherin, shRNA-ILK and rTGF-B on CD103, phospho-ILK and TGFBRI polarization (S4); Effects of TGF-B and chemical inhibitors on granzyme B polarization or redirected target cell lysis (S5).
Supplementary Experimental Procedures from Aspirin Suppresses the Acquisition of Chemoresistance in Breast Cancer by Disrupting an NFκB–IL6 Signaling Axis Responsible for the Generation of Cancer Stem Cells
Authors: Saha Shilpi , Mukherjee Shravanti , Khan Poulami , Kajal Kirti , Mazumdar Minakshi , Manna Argha , Mukherjee Sanhita , De Sunanda , Jana Debarshi , Sarkar Diptendra K. , Das Tanya
Published: March 2023

Detail description of determination of response to neo-adjuvant chemotherapy, Western blotting, RT-PCR Assay, ELISA, chromatin immunoprecipitation assay and immunohistochemistry
Supplementary Figure and Movie Legend from TGFβ Signaling Intersects with CD103 Integrin Signaling to Promote T-Lymphocyte Accumulation and Antitumor Activity in the Lung Tumor Microenvironment
Authors: Boutet Marie , Gauthier Ludiane , Leclerc Marine , Gros Gwendoline , de Montpreville Vincent , Théret Nathalie , Donnadieu Emmanuel , Mami-Chouaib Fathia
Published: March 2023

Legend for Supplementary Figures S1-S5 and Supplementary Movies.
Supplemental methods, references, figure legends and figures S1-S7 from Myc Induces miRNA-Mediated Apoptosis in Response to HDAC Inhibition in Hematologic Malignancies
Authors: Adams Clare M. , Hiebert Scott W. , Eischen Christine M.
Published: March 2023

Supplemental methods, references, figure legends and figures S1-S7. Figure S1. HDAC inhibition causes decreased Bcl-2 and Bcl-xL protein expression and cell death in multiple hematopoietic malignancies. Figure S2. HDAC inhibition increases global histone acetylation, but no change in transcription at BCL-2 and BCL-XL loci. Figure S3. miR-15 family targets Bcl-2 to induce apoptosis. Figure S4. miR-15 family and let-7a increase in lymphomas upon HDAC inhibition and induce apoptosis. Figure S5. Myc upregulates members of the miR-15 family and let-7a in untransformed cells. Figure S6. MYC ChIPs to the promoters of the miR-15 family and let-7a and HDACi induces miR-15 family and let-7a expression. Figure S7. Myc:Miz-1 interactions do not mediate Bcl-2 and Bcl-XL repression.
Supplementary Figure Legends from Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling
Authors: Peng Dongjun , Tanikawa Takashi , Li Wei , Zhao Lili , Vatan Linda , Szeliga Wojciech , Wan Shanshan , Wei Shuang , Wang Yin , Liu Yan , Staroslawska Elzbieta , Szubstarski Franciszek , Rolinski Jacek , Grywalska Ewelina , Stanisławek Andrzej , Polkowski Wojciech , Kurylcio Andrzej , Kleer Celina , Chang Alfred E. , Wicha Max , Sabel Michael , Zou Weiping , Kryczek Ilona
Published: March 2023

Supplementary Figure 1 MDSC phenotype and suppressor activity Supplementary Figure 2 MDSCs in breast cancer tissues Supplementary Figure 3 Relationship between MDSCs and breast cancer stemness Supplementary Figure 4 MDSCs produce NO and IL-6 and induce tumor STAT3 phosphorylation Supplementary Figure 5 Correlations between CD33, ALDH1A1 and IL6 transcripts in patients with breast cancer
Supplemental Fig.S4. from HEATR1 Negatively Regulates Akt to Help Sensitize Pancreatic Cancer Cells to Chemotherapy
Authors: Liu Tongzheng , Fang Yuan , Zhang Haoxing , Deng Min , Gao Bowen , Niu Nifang , Yu Jia , Lee SeungBaek , Kim JungJin , Qin Bo , Xie Fang , Evans Debra , Wang Liewei , Lou Wenhui , Lou Zhenkun
Published: March 2023

Supplemental Fig.S4. Akt inhibitor sensitizes pancreatic tumors with HEATR1 knockdown to gemcitabine.
Supplemental Data from HEATR1 Negatively Regulates Akt to Help Sensitize Pancreatic Cancer Cells to Chemotherapy
Authors: Liu Tongzheng , Fang Yuan , Zhang Haoxing , Deng Min , Gao Bowen , Niu Nifang , Yu Jia , Lee SeungBaek , Kim JungJin , Qin Bo , Xie Fang , Evans Debra , Wang Liewei , Lou Wenhui , Lou Zhenkun
Published: March 2023

Supplemental data includes supplement materials, methods and data
Supplemental Figure 2 from In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments
Authors: Morris Zachary S. , Guy Emily I. , Francis David M. , Gressett Monica M. , Werner Lauryn R. , Carmichael Lakeesha L. , Yang Richard K. , Armstrong Eric A. , Huang Shyhmin , Navid Fariba , Gillies Stephen D. , Korman Alan , Hank Jacquelyn A. , Rakhmilevich Alexander L. , Harari Paul M. , Sondel Paul M.
Published: March 2023

Following radiation, IT injection of hu14.18K322A improves tumor response compared to IV delivery.
Supplemental Figure 1 from In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments
Authors: Morris Zachary S. , Guy Emily I. , Francis David M. , Gressett Monica M. , Werner Lauryn R. , Carmichael Lakeesha L. , Yang Richard K. , Armstrong Eric A. , Huang Shyhmin , Navid Fariba , Gillies Stephen D. , Korman Alan , Hank Jacquelyn A. , Rakhmilevich Alexander L. , Harari Paul M. , Sondel Paul M.
Published: March 2023

Combined treatment with radiation and tumor-specific mAb or IC does not impact mouse weight.
Supplementary Figure S5 from Chemotherapy-Induced miRNA-29c/Catenin-δ Signaling Suppresses Metastasis in Gastric Cancer
Authors: Wang Yuxuan , Liu Changzheng , Luo Min , Zhang Zhengyi , Gong Jianan , Li Jingjing , You Lei , Dong Lei , Su Rui , Lin Haishuang , Ma Yanni , Wang Fang , Wang Yi , Chen Jie , Zhang Junwu , Jia Hongyan , Kong Yan , Yu Jia
Published: March 2023

Supplementary Figure S5. The suppressive effect of miR-29c on GC formation.
Supplemental Materials and Methods from Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth
Authors: Pathania Rajneesh , Ramachandran Sabarish , Mariappan Gurusamy , Thakur Priyanka , Shi Huidong , Choi Jeong-Hyeon , Manicassamy Santhakumar , Kolhe Ravindra , Prasad Puttur D. , Sharma Suash , Lokeshwar Bal L. , Ganapathy Vadivel , Thangaraju Muthusamy
Published: March 2023

The Supplemental materials and method file has methods for the Generation of mammospheres and tumorospheres, Preparation of single cell suspension from mammary gland, methods for RNA Isolation and Real-time PCR, and Clonogenic assay.
Supplementary Figure Legends from Agonists of the TRAIL Death Receptor DR5 Sensitize Intestinal Stem Cells to Chemotherapy-Induced Cell Death and Trigger Gastrointestinal Toxicity
Authors: Finnberg Niklas K. , Gokare Prashanth , Navaraj Arunasalam , Lang Kuhs Krystle A. , Cerniglia George , Yagita Hideo , Takeda Kazuyoshi , Motoyama Noboru , El-Deiry Wafik S.
Published: March 2023

Supplementary Figure Legends for Supplementary Figures 1-9.
Supplementary Table S6 from Transcriptome Analysis of Recurrently Deregulated Genes across Multiple Cancers Identifies New Pan-Cancer Biomarkers
Authors: Kaczkowski Bogumil , Tanaka Yuji , Kawaji Hideya , Sandelin Albin , Andersson Robin , Itoh Masayoshi , Lassmann Timo , Hayashizaki Yoshihide , Carninci Piero , Forrest Alistair R.R.
Published: March 2023

ChIA-PET associations between differentially expressed enhancerRNAs (eRNAs) and promoters of annotated genes.
Supplementary Table S5 from Transcriptome Analysis of Recurrently Deregulated Genes across Multiple Cancers Identifies New Pan-Cancer Biomarkers
Authors: Kaczkowski Bogumil , Tanaka Yuji , Kawaji Hideya , Sandelin Albin , Andersson Robin , Itoh Masayoshi , Lassmann Timo , Hayashizaki Yoshihide , Carninci Piero , Forrest Alistair R.R.
Published: March 2023

Results of EdgeR Differential Expression Analysis.
Fig.S6 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer
Authors: Quemener Cathy , Baud Jessica , Boyé Kevin , Dubrac Alexandre , Billottet Clotilde , Soulet Fabienne , Darlot Florence , Dumartin Laurent , Sire Marie , Grepin Renaud , Daubon Thomas , Rayne Fabienne , Wodrich Harald , Couvelard Anne , Pineau Raphael , Schilling Martin , Castronovo Vincent , Sue Shih-Che , Clarke Kim , Lomri Abderrahim , Khatib Abdel-Majid , Hagedorn Martin , Prats Hervé , Bikfalvi Andreas
Published: March 2023

In vivo characterization of the MabL1 antibody
Supplementary Table S4 from Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer
Authors: Ando Mizuo , Kawazu Masahito , Ueno Toshihide , Koinuma Daizo , Ando Koji , Koya Junji , Kataoka Keisuke , Yasuda Takahiko , Yamaguchi Hiroyuki , Fukumura Kazutaka , Yamato Azusa , Soda Manabu , Sai Eirin , Yamashita Yoshihiro , Asakage Takahiro , Miyazaki Yasushi , Kurokawa Mineo , Miyazono Kohei , Nimer Stephen D. , Yamasoba Tatsuya , Mano Hiroyuki
Published: March 2023

Genes specifically induced by ELF4(L211M) in T3M-1 Cl-10 cells
Fig.S2 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer
Authors: Quemener Cathy , Baud Jessica , Boyé Kevin , Dubrac Alexandre , Billottet Clotilde , Soulet Fabienne , Darlot Florence , Dumartin Laurent , Sire Marie , Grepin Renaud , Daubon Thomas , Rayne Fabienne , Wodrich Harald , Couvelard Anne , Pineau Raphael , Schilling Martin , Castronovo Vincent , Sue Shih-Che , Clarke Kim , Lomri Abderrahim , Khatib Abdel-Majid , Hagedorn Martin , Prats Hervé , Bikfalvi Andreas
Published: March 2023

CXCL4L1 and CXCL4 gene expression analysis
Supplementary Figure S3 from HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc
Authors: Li Yinghui , Wang Zhen , Shi Hui , Li Hang , Li Leilei , Fang Runping , Cai Xiaoli , Liu Bowen , Zhang Xiaodong , Ye Lihong
Published: March 2023

HBXIP is able to interact with c-Myc.
Suppl. materials from Non–Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases
Authors: Isozaki Hideko , Ichihara Eiki , Takigawa Nagio , Ohashi Kadoaki , Ochi Nobuaki , Yasugi Masayuki , Ninomiya Takashi , Yamane Hiromichi , Hotta Katsuyuki , Sakai Katsuya , Matsumoto Kunio , Hosokawa Shinobu , Bessho Akihiro , Sendo Toshiaki , Tanimoto Mitsune , Kiura Katsuyuki
Published: March 2023

Suppl. materials
Supplementary Figure S2 from Exosomes Derived from Hypoxic Oral Squamous Cell Carcinoma Cells Deliver miR-21 to Normoxic Cells to Elicit a Prometastatic Phenotype
Authors: Li Ling , Li Chao , Wang Shaoxin , Wang Zhaohui , Jiang Jian , Wang Wei , Li Xiaoxia , Chen Jin , Liu Kun , Li Chunhua , Zhu Guiquan
Published: March 2023

miR-21 expression levels in exosomes and SCC-9 cells cultured under normoxia and hypoxia were measured by quantitative real-time PCR.
Suppl. Figure 1 from Non–Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases
Authors: Isozaki Hideko , Ichihara Eiki , Takigawa Nagio , Ohashi Kadoaki , Ochi Nobuaki , Yasugi Masayuki , Ninomiya Takashi , Yamane Hiromichi , Hotta Katsuyuki , Sakai Katsuya , Matsumoto Kunio , Hosokawa Shinobu , Bessho Akihiro , Sendo Toshiaki , Tanimoto Mitsune , Kiura Katsuyuki
Published: March 2023

Establishing a method for the alectinib-resistant cell lines and morphological observations
Supplementary Table 1, Supplementary Figures 1 through 9, and Supplementary Materials and Methods from Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation
Authors: Marmary Yitzhak , Adar Revital , Gaska Svetlana , Wygoda Annette , Maly Alexander , Cohen Jonathan , Eliashar Ron , Mizrachi Lina , Orfaig-Geva Carmit , Baum Bruce J. , Rose-John Stefan , Galun Eithan , Axelrod Jonathan H.
Published: March 2023

Supplementary Table S1 - Patient Characteristics Supplementary Fig. S1 - IR-induced morphology and inflammatory responses Supplementary Fig. S2 - Apoptosis following IR Supplementary Fig. S3 - Morphology, Aquaporin and ??H2AX in Acini following IR Supplementary Fig. S4 - IL-6 is crucial for persistence of DDR Supplementary Fig. S5 - IL-6 infusion induces IL-6 upregulation. Supplementary Fig. S6 - IL-6 and HIL-6 pretreatment reduces persistent DDR Supplementary Fig. S7 - IL-6 pretreatment accelerates DNA damage repair Supplementary Fig. S8 - IL-6 deficiency does not affect DDR Supplementary Fig. S9 - HIL-6 pretreatment does not affect distal tumor radiotherapy Supplementary Figure Legends Supplementary Materials and Methods
Supplemental Material from Decoding Intratumoral Heterogeneity of Breast Cancer by Multiparametric In Vivo Imaging: A Translational Study
Authors: Schmitz Jennifer , Schwab Julian , Schwenck Johannes , Chen Qian , Quintanilla-Martinez Leticia , Hahn Markus , Wietek Beate , Schwenzer Nina , Staebler Annette , Kohlhofer Ursula , Aina Olulanu H. , Hubbard Neil E. , Reischl Gerald , Borowsky Alexander D. , Brucker Sara , Nikolaou Konstantin , la Fougère Christian , Cardiff Robert D. , Pichler Bernd J. , Schmid Andreas M.
Published: March 2023

More detailed description of ex-vivo procedures of mouse tumor samples
Supplementary Figure Legends from AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation
Authors: Li Chia-Wei , Xia Weiya , Lim Seung-Oe , Hsu Jennifer L. , Huo Longfei , Wu Yun , Li Long-Yuan , Lai Chien-Chen , Chang Shih-Shin , Hsu Yi-Hsin , Sun Hui-Lung , Kim Jongchan , Yamaguchi Hirohito , Lee Dung-Fang , Wang Hongmei , Wang Yan , Chou Chao-Kai , Hsu Jung-Mao , Lai Yun-Ju , LaBaff Adam M. , Ding Qingqing , Ko How-Wen , Tsai Fuu-Jen , Tsai Chang-Hai , Hortobagyi Gabriel N. , Hung Mien-Chie
Published: March 2023

Supplementary Figure Legends
Supplementary Table 4 from Phosphotyrosine Signaling Analysis in Human Tumors Is Confounded by Systemic Ischemia-Driven Artifacts and Intra-Specimen Heterogeneity
Authors: Gajadhar Aaron S. , Johnson Hannah , Slebos Robbert J.C. , Shaddox Kent , Wiles Kerry , Washington Mary Kay , Herline Alan J. , Levine Douglas A. , Liebler Daniel C. , White Forest M.
Published: March 2023

Supplementary Table 4. Summary of colon tumor iTRAQ LC-MS/MS pTyr analysis
Figure S3: Expression of siRNA-resistant RASSF1A rescues EMT phenotype induced by RASSF1A depletion. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway
Authors: Dubois Fatéméh , Keller Maureen , Calvayrac Olivier , Soncin Fabrice , Hoa Lily , Hergovich Alexander , Parrini Maria-Carla , Mazières Julien , Vaisse-Lesteven Mélissa , Camonis Jacques , Levallet Guénaëlle , Zalcman Gérard
Published: March 2023

HBEC-3 cells were transiently transfected with siNeg or siRASSF1A in association with either pcDNA3-RASSF1A or pcDNA3-RASSF1C. The experiences were performed 48 hours after transfection. A. Representative images for RASSF1A expression changes by immunofluorescence and confocal microscopy. RASSF1A primary antibody (Red) followed by Alexa 555 conjugated secondary antibody along with DAPI for DNA (Blue) was used as a control along with DAPI for DNA (Blue). Scale bar represents 50 µm. B. Representative blots for quantification of Twist and Vimentin proteins levels by western blotting in HBEC-3 cells. Actin was used as an internal control. (n=2) C. The migration speed (µm/h) of transfected HBEC-3 cells was determined by wound healing assay on collagen I & IV. Mitomycin C (1 µg/ml) was added to medium 12h before scratch in order to limit cell proliferation. D. Representative images for nuclear localization of Yap in HBEC-3 cell by immunofluorescence and confocal microscopy. The cells stained by Yap primary antibody (Green) followed by Alexa488 conjugated secondary antibody, along with DAPI for DNA (Blue). Scale bar represents 50 µm. For all of the histograms, error bars indicate the standard error of the mean (SEM) of at least three independent experiments. *p<0.05, **p<0.01 and ***p<0.001, using an ANOVA test followed by Dunnett's test.
Supplemental Figure S6 from Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem–like Cells
Authors: Giraud Julie , Failla Laura M. , Pascussi Jean-Marc , Lagerqvist Ebba L. , Ollier Jérémy , Finetti Pascal , Bertucci François , Ya Chu , Gasmi Imène , Bourgaux Jean-François , Prudhomme Michel , Mazard Thibault , Ait-Arsa Imade , Houhou Leila , Birnbaum Daniel , Pélegrin André , Vincent Charles , Ryall James G. , Joubert Dominique , Pannequin Julie , Hollande Frédéric
Published: March 2023

Annexin II expression is not enriched in cancer stem cell populations.
Figure S1: Scheme of RASSF1 splicing isoforms and localization annealing regions of siRNAs and shRNAs used. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway
Authors: Dubois Fatéméh , Keller Maureen , Calvayrac Olivier , Soncin Fabrice , Hoa Lily , Hergovich Alexander , Parrini Maria-Carla , Mazières Julien , Vaisse-Lesteven Mélissa , Camonis Jacques , Levallet Guénaëlle , Zalcman Gérard
Published: March 2023

RASSF1 eight coding exon regions are represented along with the eight different transcripts arising from alternative splicing with the use of two different promoters. Only siRASSF1A and shRASSF1A-777, by annealing to 1alpha exon are able to deplete the mRNA species transcribed from the first promoter proceeding 1alpha(RASSF1A, D, E , F, G, H), whereas siRASSF1AC and shRASSF1A-779, by annealing to exon 4 or 4-5 respectively, are able to deplete all species, since they all contain exon 4. The 737 bp CpG island methylated in human cancers spans the first promoter for RASSF1A, D, E, F, G, H.
Supplementary Figure 9 from Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB–Controlled Oxidative Stress Responses
Authors: Shono Yusuke , Tuckett Andrea Z. , Liou Hsiou-Chi , Doubrovina Ekaterina , Derenzini Enrico , Ouk Samedy , Tsai Jennifer J. , Smith Odette M. , Levy Emily R. , Kreines Fabiana M. , Ziegler Carly G.K. , Scallion Mary I. , Doubrovin Mikhail , Heller Glenn , Younes Anas , O'Reilly Richard J. , van den Brink Marcel R.M. , Zakrzewski Johannes L.
Published: March 2023

IT-901 mediates anti-lymphoma activity in a xenograft model of EBV-induced lymphoma.
Supplementary Figure 5 from Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB–Controlled Oxidative Stress Responses
Authors: Shono Yusuke , Tuckett Andrea Z. , Liou Hsiou-Chi , Doubrovina Ekaterina , Derenzini Enrico , Ouk Samedy , Tsai Jennifer J. , Smith Odette M. , Levy Emily R. , Kreines Fabiana M. , Ziegler Carly G.K. , Scallion Mary I. , Doubrovin Mikhail , Heller Glenn , Younes Anas , O'Reilly Richard J. , van den Brink Marcel R.M. , Zakrzewski Johannes L.
Published: March 2023

Treatment with IT-901 for 14 days does not alter lymphocyte numbers.
Supplemental Figure 4 from M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers
Authors: Ohashi Yoshimi , Okamura Mutsumi , Hirosawa Asaka , Tamaki Naomi , Akatsuka Akinobu , Wu Kuo-Ming , Choi Hyeong-Wook , Yoshimatsu Kentaro , Shiina Isamu , Yamori Takao , Dan Shingo
Published: March 2023

The effect of M-COPA on cell surface expression of BCRP1 and P-glycoprotein (MDR1).
Supplementary Tables and Figures from IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis
Authors: Brooks Gavin D. , McLeod Louise , Alhayyani Sultan , Miller Alistair , Russell Prudence A. , Ferlin Walter , Rose-John Stefan , Ruwanpura Saleela , Jenkins Brendan J.
Published: March 2023

Table S1: Clinicopathological features of LAC patients and control LAC-free individuals. Table S2: Primers used in qPCR assays. Figure S1: Augmented Kras-induced lung adenocarcinoma in gp130F/F mice is not associated with enhanced inflammation. Figure S2: Gene expression analyses during KrasG12D-induced lung carcinogenesis. Figure S3: IL-6 deficiency in the lungs of gp130F/F:KrasG12D mice suppresses cellular apoptosis and inflammation. Figure S4: Nuclear expression of tyrosine-phosphorylated (activated) STAT3 in the epithelial lesions in the lungs of F/F:KrasG12D mice. Figure S5: Reduced STAT3 activation in the lungs of gp130F/F mice upon genetic ablation of IL-6 trans-signaling with sgp130Fc. Figure S6: Blockade of IL-6 trans-signaling with mAbs in KrasG12D mice reduces lung carcinogenesis. Figure S7: Blockade of IL-6 trans-signaling suppresses the growth of human LAC cell lines.
Supplementary Methods and References from Quantitative Phosphotyrosine Profiling of Patient-Derived Xenografts Identifies Therapeutic Targets in Pediatric Leukemia
Authors: Dolai Sibasish , Sia Keith C.S. , Robbins Alissa K. , Zhong Ling , Heatley Sue L. , Vincent Tiffaney L. , Hochgräfe Falko , Sutton Rosemary , Kurmasheva Raushan T. , Revesz Tamas , White Deborah L. , Houghton Peter J. , Smith Malcolm A. , Teachey David T. , Daly Roger J. , Raftery Mark J. , Lock Richard B.
Published: March 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Supplementary Figures S1-S9 from Quantitative Phosphotyrosine Profiling of Patient-Derived Xenografts Identifies Therapeutic Targets in Pediatric Leukemia
Authors: Dolai Sibasish , Sia Keith C.S. , Robbins Alissa K. , Zhong Ling , Heatley Sue L. , Vincent Tiffaney L. , Hochgräfe Falko , Sutton Rosemary , Kurmasheva Raushan T. , Revesz Tamas , White Deborah L. , Houghton Peter J. , Smith Malcolm A. , Teachey David T. , Daly Roger J. , Raftery Mark J. , Lock Richard B.
Published: March 2023

Phosphotyrosine sites identified by immunoaffinity profiling in ALL PDXs (S1); Comparison of phosphotyrosine enrichment from fresh and frozen PDX (S2); Optimization of quantitative phosphotyrosine profiling of pediatric ALL PDXs (S3); Number of identified Class I phosphosites in each of the PDXs (S4); Unsupervised hierarchical clustering of Class I phosphosites in ALL PDXs segregated based on molecularly-defined subgroups (S5); Comparison of ETP-ALL, Ph-like-ALL, BCP-ALL and T-ALL PDXs by gene expression profiling (S6); Comparison of phosphorylation levels of pTyr sites with gene expression profiling (S7); In vitro sensitivity of ALL PDXs to Sunitinib (S8); Venn diagram showing the number of Light PDX phosphopeptides and Heavy SILAC labelled phosphopeptides identified in each of the 16 PDXs (S9).
Supplementary Figure Legends from Quantitative Phosphotyrosine Profiling of Patient-Derived Xenografts Identifies Therapeutic Targets in Pediatric Leukemia
Authors: Dolai Sibasish , Sia Keith C.S. , Robbins Alissa K. , Zhong Ling , Heatley Sue L. , Vincent Tiffaney L. , Hochgräfe Falko , Sutton Rosemary , Kurmasheva Raushan T. , Revesz Tamas , White Deborah L. , Houghton Peter J. , Smith Malcolm A. , Teachey David T. , Daly Roger J. , Raftery Mark J. , Lock Richard B.
Published: March 2023

Legend for Supplementary Figures S1-S9.
Supplementary Table 2 from Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer
Authors: Dou Qianhui , Chen Hai-Ning , Wang Kui , Yuan Kefei , Lei Yunlong , Li Kai , Lan Jiang , Chen Yan , Huang Zhao , Xie Na , Zhang Lu , Xiang Rong , Nice Edouard C. , Wei Yuquan , Huang Canhua
Published: March 2023

Supplementary Table 2
Supplementary Figure Legends from Aberrant Activation of Notch Signaling Inhibits PROX1 Activity to Enhance the Malignant Behavior of Thyroid Cancer Cells
Authors: Choi Dongwon , Ramu Swapnika , Park Eunkyung , Jung Eunson , Yang Sara , Jung Wonhyeuk , Choi Inho , Lee Sunju , Kim Kyu Eui , Seong Young Jin , Hong Mingu , Daghlian George , Kim Daniel , Shin Eugene , Seo Jung In , Khatchadourian Vicken , Zou Mengchen , Li Wei , De Filippo Roger , Kokorowski Paul , Chang Andy , Kim Steve , Bertoni Ana , Furlanetto Tania Weber , Shin Sung , Li Meng , Chen Yibu , Wong Alex , Koh Chester , Geliebter Jan , Hong Young-Kwon
Published: March 2023

Supplementary Figure Legends
Supplementary Figure S7-9 from Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer
Authors: Dou Qianhui , Chen Hai-Ning , Wang Kui , Yuan Kefei , Lei Yunlong , Li Kai , Lan Jiang , Chen Yan , Huang Zhao , Xie Na , Zhang Lu , Xiang Rong , Nice Edouard C. , Wei Yuquan , Huang Canhua
Published: March 2023

Supplementary Figure S7-9
Supplementary Figure Legends from Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer
Authors: Dou Qianhui , Chen Hai-Ning , Wang Kui , Yuan Kefei , Lei Yunlong , Li Kai , Lan Jiang , Chen Yan , Huang Zhao , Xie Na , Zhang Lu , Xiang Rong , Nice Edouard C. , Wei Yuquan , Huang Canhua
Published: March 2023

Supplementary Figure Legends
Supplemental Table and Figure Legends from Identification of Bone-Derived Factors Conferring De Novo Therapeutic Resistance in Metastatic Prostate Cancer
Authors: Lee Yu-Chen , Lin Song-Chang , Yu Guoyu , Cheng Chien-Jui , Liu Bin , Liu Hsuan-Chen , Hawke David H. , Parikh Nila U. , Varkaris Andreas , Corn Paul , Logothetis Christopher , Satcher Robert L. , Yu-Lee Li-Yuan , Gallick Gary E. , Lin Sue-Hwa
Published: March 2023

Legends for Supplemental Tables S1-S2 and Supplemental Figures S1-S6.
Supplemental Figure S4 from Identification of Bone-Derived Factors Conferring De Novo Therapeutic Resistance in Metastatic Prostate Cancer
Authors: Lee Yu-Chen , Lin Song-Chang , Yu Guoyu , Cheng Chien-Jui , Liu Bin , Liu Hsuan-Chen , Hawke David H. , Parikh Nila U. , Varkaris Andreas , Corn Paul , Logothetis Christopher , Satcher Robert L. , Yu-Lee Li-Yuan , Gallick Gary E. , Lin Sue-Hwa
Published: March 2023

FAK inhibitor defactinib inhibited PC3-mm2 cell survival in vitro.
supplemental figure legends from Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells
Authors: Shi Yijiang , Daniels-Wells Tracy R. , Frost Patrick , Lee Jihye , Finn Richard S. , Bardeleben Carolyne , Penichet Manuel L. , Jung Michael E. , Gera Joseph , Lichtenstein Alan
Published: March 2023

legends of supplemental figures
Supplementary Figure 4 from GSK-3 Inhibition Sensitizes Acute Myeloid Leukemia Cells to 1,25D-Mediated Differentiation
Authors: Gupta Kalpana , Stefan Tammy , Ignatz-Hoover James , Moreton Stephen , Parizher Gary , Saunthararajah Yogen , Wald David N.
Published: March 2023

Genes exhibiting significant changes in the gene expression after 1,25D and GSK3 inhibitor treatment
supplemental figure 2 from Cytotoxic Properties of a DEPTOR-mTOR Inhibitor in Multiple Myeloma Cells
Authors: Shi Yijiang , Daniels-Wells Tracy R. , Frost Patrick , Lee Jihye , Finn Richard S. , Bardeleben Carolyne , Penichet Manuel L. , Jung Michael E. , Gera Joseph , Lichtenstein Alan
Published: March 2023

SUPPL FIG 2: A) 8226 cells treated with or w/o NSC 126405 for 6 hrs, followed by immunoprecipitation of mTOR (or control IgG). Immunoprecipitates immunoblotted for expression of mTOR and DEPTOR. Input shown for DEPTOR, mTOR and tubulin expression. B) 8226 cells treated with DMSO, pp242 or NSC 126405 and then tested for 4E-BP1 phosphorylation by flow cytometry. C) Summarized data from all 3 treatment groups
Supplementary Figure Legends from A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk
Authors: Travis Ruth C. , Appleby Paul N. , Martin Richard M. , Holly Jeff M.P. , Albanes Demetrius , Black Amanda , Bueno-de-Mesquita H. Bas , Chan June M. , Chen Chu , Chirlaque Maria-Dolores , Cook Michael B. , Deschasaux Mélanie , Donovan Jenny L. , Ferrucci Luigi , Galan Pilar , Giles Graham G. , Giovannucci Edward L. , Gunter Marc J. , Habel Laurel A. , Hamdy Freddie C. , Helzlsouer Kathy J. , Hercberg Serge , Hoover Robert N. , Janssen Joseph A.M.J.L. , Kaaks Rudolf , Kubo Tatsuhiko , Le Marchand Loic , Metter E. Jeffrey , Mikami Kazuya , Morris Joan K. , Neal David E. , Neuhouser Marian L. , Ozasa Kotaro , Palli Domenico , Platz Elizabeth A. , Pollak Michael N. , Price Alison J. , Roobol Monique J. , Schaefer Catherine , Schenk Jeannette M. , Severi Gianluca , Stampfer Meir J. , Stattin Pär , Tamakoshi Akiko , Tangen Catherine M. , Touvier Mathilde , Wald Nicholas J. , Weiss Noel S. , Ziegler Regina G. , Key Timothy J. , Allen Naomi E.
Published: March 2023

Supplementary Figure Legends for Figures S1-S15.
Supplemental methods from An Akt3 Splice Variant Lacking the Serine 472 Phosphorylation Site Promotes Apoptosis and Suppresses Mammary Tumorigenesis
Authors: Suyama Kimita , Yao Jiahong , Liang Huizhi , Benard Outhiriaradjou , Loudig Olivier D. , Amgalan Dulguun , McKimpson Wendy M. , Phillips Greg R. , Segall Jeffrey , Wang Yihong , Fineberg Susan , Norton Larry , Kitsis Richard N. , Hazan Rachel B.
Published: March 2023

Supplemental methods
Supplementary Table 1 from T-cell Landscape in a Primary Melanoma Predicts the Survival of Patients with Metastatic Disease after Their Treatment with Dendritic Cell Vaccines
Authors: Vasaturo Angela , Halilovic Altuna , Bol Kalijn F. , Verweij Dagmar I. , Blokx Willeke A.M. , Punt Cornelis J.A. , Groenen Patricia J.T.A. , van Krieken J. Han J.M. , Textor Johannes , de Vries I. Jolanda M. , Figdor Carl G.
Published: March 2023

Summary of all analyzed primary tumor slides used in the analysis, using the same format as in Figure 1B of the main manuscript to illustrate the T cell landscapes.
Supplementary Figure 1 from T-cell Landscape in a Primary Melanoma Predicts the Survival of Patients with Metastatic Disease after Their Treatment with Dendritic Cell Vaccines
Authors: Vasaturo Angela , Halilovic Altuna , Bol Kalijn F. , Verweij Dagmar I. , Blokx Willeke A.M. , Punt Cornelis J.A. , Groenen Patricia J.T.A. , van Krieken J. Han J.M. , Textor Johannes , de Vries I. Jolanda M. , Figdor Carl G.
Published: March 2023

Multispectral imaging and melanin unmixing using automated quantitative analysis of tumor infiltrating lymphocytes by Vectra/InForm platform.
Supplemental Materials and Methods from Mesenchymal Stem Cell–Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow
Authors: Bliss Sarah A. , Sinha Garima , Sandiford Oleta A. , Williams Lisa M. , Engelberth Daniel J. , Guiro Khadidiatou , Isenalumhe Leidy L. , Greco Steven J. , Ayer Seda , Bryan Margarette , Kumar Rakesh , Ponzio Nicholas M. , Rameshwar Pranela
Published: March 2023

Material and Methods for Supplemental Information and extended methods from figures in the text
Supplementary Figure 3 from miR-155 Drives Metabolic Reprogramming of ER+ Breast Cancer Cells Following Long-Term Estrogen Deprivation and Predicts Clinical Response to Aromatase Inhibitors
Authors: Bacci Marina , Giannoni Elisa , Fearns Antony , Ribas Ricardo , Gao Qiong , Taddei Maria Letizia , Pintus Gianfranco , Dowsett Mitch , Isacke Clare M. , Martin Lesley-Ann , Chiarugi Paola , Morandi Andrea
Published: March 2023

Supplementary Figure S3. 2-DG and metformin treatment do not cause apoptosis to the ER+ MCF7-LTED cells but impair survival fraction of the ER- ZR75-LTED.
Supplementary Figure 1 from Tumor Eradication by Cisplatin Is Sustained by CD80/86-Mediated Costimulation of CD8+ T Cells
Authors: Beyranvand Nejad Elham , van der Sluis Tetje C. , van Duikeren Suzanne , Yagita Hideo , Janssen George M. , van Veelen Peter A. , Melief Cornelis J.M. , van der Burg Sjoerd H. , Arens Ramon
Published: March 2023

The maximum tolerated dose (MTD) of cisplatin does not induce liver or organ toxicity.
Supplemental Information from Frequency and Dynamics of Leukemia-Initiating Cells during Short-term Ex Vivo Culture Informs Outcomes in Acute Myeloid Leukemia Patients
Authors: Griessinger Emmanuel , Anjos-Afonso Fernando , Vargaftig Jacques , Taussig David C. , Lassailly François , Prebet Thomas , Imbert Véronique , Nebout Marielle , Vey Norbert , Chabannon Christian , Filby Andrew , Bollet-Quivogne Frederic , Gribben John G. , Peyron Jean-François , Bonnet Dominique
Published: March 2023

Supplemental Information
Supplementary Tables from Race Disparities in the Contribution of miRNA Isoforms and tRNA-Derived Fragments to Triple-Negative Breast Cancer
Authors: Telonis Aristeidis G. , Rigoutsos Isidore
Published: March 2023

This file contains all Supplementary tables that include in detail the results of analyses of differential expression, correlation, data integration, pathway enrichment and sequence similarity.
Figure S2&S3 from Restraining Network Response to Targeted Cancer Therapies Improves Efficacy and Reduces Cellular Resistance
Authors: Das Tirtha K. , Esernio Jessica , Cagan Ross L.
Published: March 2023

Figure S2, S3, shows effect of different doses of sorafenib on wing phenotype and cellular pathways in flies
Supplementary Table S1 from Delivery of Therapeutics Targeting the mRNA-Binding Protein HuR Using 3DNA Nanocarriers Suppresses Ovarian Tumor Growth
Authors: Huang Yu-Hung , Peng Weidan , Furuuchi Narumi , Gerhart Jacquelyn , Rhodes Kelly , Mukherjee Neelanjan , Jimbo Masaya , Gonye Gregory E. , Brody Jonathan R. , Getts Robert C. , Sawicki Janet A.
Published: March 2023

Supplementary Table S1. Biological function of 5 up-regulated and 6 down-regulated genes having the highest fold differences in expression in response to HuR inhibition in A2780 cells. Shaded boxes indicate transcripts to which HuR binds directly.
Figure S1 from Tissue Stiffness and Hypoxia Modulate the Integrin-Linked Kinase ILK to Control Breast Cancer Stem-like Cells
Authors: Pang Mei-Fong , Siedlik Michael J. , Han Siyang , Stallings-Mann Melody , Radisky Derek C. , Nelson Celeste M.
Published: March 2023

Stiff and hypoxic microenvironments regulate beta1-integrin, ILK, and CSC markers in human breast cancer cells. (A) Phase contrast images of MDA-MB-231 cells cultured on soft or stiff substrata under normoxia or hypoxia. Transcript levels of (B) ITGB1 and (C) ILK in MDA-MB-231 cells cultured on soft or stiff substrata under normoxia or hypoxia. (D) Immunoblotting analysis for beta1-integrin, ILK, and GAPDH in MDA-MB-231 cells cultured on soft or stiff substrata under normoxia or hypoxia. Transcript levels of (E) CD44, (F) Nanog, and (G) CD49f in MDA-MB-231 cells cultured on soft or stiff substrata under normoxia or hypoxia. (H) Immunoblotting analysis for CD44 and Nanog in MDA-MB-231 cells cultured on soft or stiff substrata under normoxia or hypoxia. Histograms of flow cytometry analysis of (I) CD44 and (J) Nanog expression in 4T1 cells cultured on soft or stiff substrata under normoxia or hypoxia. (K) Dot plots of flow cytometry analysis of ALDH activity in 4T1 cells cultured on soft or stiff substrata under normoxia or hypoxia. Scale bars, 50 µm. Shown are mean (plus minus) s.e.m. *, P<0.05; **, P<0.01; ***, P<0.001.
Supplementary methods and supplementary figure legends from Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming
Authors: Rodriguez-Ruiz María E. , Rodriguez Inmaculada , Garasa Saray , Barbes Benigno , Solorzano Jose Luis , Perez-Gracia Jose Luis , Labiano Sara , Sanmamed Miguel F. , Azpilikueta Arantza , Bolaños Elixabet , Sanchez-Paulete Alfonso R. , Aznar M. Angela , Rouzaut Ana , Schalper Kurt A. , Jure-Kunkel Maria , Melero Ignacio
Published: March 2023

supplementary figure legends and supplementary material and methods section.
Supplementary Figure 1 from Endothelial Side Population Cells Contribute to Tumor Angiogenesis and Antiangiogenic Drug Resistance
Authors: Naito Hisamichi , Wakabayashi Taku , Kidoya Hiroyasu , Muramatsu Fumitaka , Takara Kazuhiro , Eino Daisuke , Yamane Keitaro , Iba Tomohiro , Takakura Nobuyuki
Published: March 2023

EC-SP and -MP cells are in the active phase of the cell cycle in the tumor microenvironment.
Supplementary Video 2 from Eritoran Suppresses Colon Cancer by Altering a Functional Balance in Toll-like Receptors That Bind Lipopolysaccharide
Authors: Kuo Wei-Ting , Lee Tsung-Chun , Yu Linda Chia-Hui
Published: March 2023

Time lapse imaging of mouse tumor spheroid growth after exposure to LPS (1 μg/ml) for 48 h.
Supplementary Video 1 from Eritoran Suppresses Colon Cancer by Altering a Functional Balance in Toll-like Receptors That Bind Lipopolysaccharide
Authors: Kuo Wei-Ting , Lee Tsung-Chun , Yu Linda Chia-Hui
Published: March 2023

Time lapse imaging of mouse tumor spheroid growth for 48 h.
Supplementary Table S1 from Antitumor Properties of an IgG2-Enhanced Next-Generation MET Monoclonal Antibody That Degrades Wild-Type and Mutant MET Receptors
Authors: Yang Yan , Mandiyan Sreekala , Robinson Brett S. , McMahon Gerald
Published: March 2023

Cross-species reactivity of anti-MET antibodies.
Supplementary methods from The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis
Authors: Astudillo Luisana , Da Silva Thiago G. , Wang Zhiqiang , Han Xiaoqing , Jin Ke , VanWye Jeffrey , Zhu Xiaoxia , Weaver Kelly , Oashi Taiji , Lopes Pedro E.M. , Orton Darren , Neitzel Leif R. , Lee Ethan , Landgraf Ralf , Robbins David J. , MacKerell Alexander D. , Capobianco Anthony J.
Published: March 2023

Explanation of experimental details for additional methods.
Suppl. Figure 4 from HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors
Authors: Budina-Kolomets Anna , Webster Marie R. , Leu Julia I-Ju , Jennis Matthew , Krepler Clemens , Guerrini Anastasia , Kossenkov Andrew V. , Xu Wei , Karakousis Giorgos , Schuchter Lynn , Amaravadi Ravi K. , Wu Hong , Yin Xiangfan , Liu Qin , Lu Yiling , Mills Gordon B. , Xu Xiaowei , George Donna L. , Weeraratna Ashani T. , Murphy Maureen E.
Published: March 2023

Impact of PET-16 on melanoma in vitro A. Immunoprecipitation-western analysis in the H1299 cell line using antisera to HSP70 and IgG, followed by Western blot analysis for the associated total and phosphorylated FAK. B. 1205Lu and WM852 cells were treated with DMSO or 1 μM PET-16 for 24 hours.