bluuebunny/crossref_metadata_2025 huggingface dataset:
Law in Ensuring the Safety of Genetic Technologies Against their Use for Criminal Purposes
Authors: Kruchinina N. V.
Published: August 2020

Genetic technologies offer wide prospects for socio-economic progress. At the same time, their application in practice could put at stake the interests of society, human rights and freedoms. Therefore, the development of genetic technologies requires its analysis from the standpoint of jurisprudence, thoughtful legislative regulation and protection from uncontrolled spread and criminal use. The paper analyzes different points of view on the use of genetic technologies. The author substantiates the necessity of proper legal regulation and security of the process of development of genetic technologies. The paper contains the results of the scientific research. The paper elucidates the problems related to the use of genetic technologies in the process of artificial human reproduction: imperfection of the legal framework (In particular, lack of the definition of the legal status of human embryo, lack of justification for the legality of its use for research and therapeutic purposes), the threat of the use of genetic technologies for criminal purposes. The author concludes that the use of genetic technologies for criminal purposes is especially dangerous because organized criminal groups focus their attention on genetic technologies. This gives rise to a special criminal situation that requires new approaches for effective counteraction. To this end, the priority is given to identification of crimes committed with the use of genetic technologies and analysis of the emerging practice of investigating this category of crimes. Failure to comply with standards, deviation from regulations and procedures imposed on medical care may result in harm to health or death also when the assisted reproductive technologies are used. The author has made some proposals to solve these problems with due regard to domestic and foreign experience in the use of genetic technologies in the field of human artificial reproduction (in particular, it is proposed to establish effective international cooperation in this area).
Specifics of Scientific Research in the Conditions of "Gray Zones" in Sports Competitions Regulations ("Formula 1" Case)
Authors: Kamalyan A. M.
Published: August 2020

This paper is a follow up of the paper "Peculiarities of Scientific Research in High-Performance Sports as in the Case of "Formula 1". The author examines the influence of the regulations, which are not formulated in the most obvious way, on scientific research in professional sports as in the case of Formula 1. It is emphasized that the "gray zones" represent a certain gap in legal regulation, which should be negatively assessed by the participants of the competition. At the same time, since Technical Regulations restrict the freedom of scientific research, such provisions allow engineers and designers to fully demonstrate their abilities, creativity and non-standard thinking. Some of the most striking examples in the history of the "Queen of Motorsport", when a particular team used a loophole in the legal regulation, are given. The circumstances of the emergence of innovative solutions, the reaction of competitors and the International Motorsport Federation (FIA) are presented. The author analyzes the decisions of the FIA court of Appeal in cases where a dispute about the interpretation of the rules and the legality of the use of a particular design reached the court. Special attention is given to ambiguous research results that have appeared in recent years, including the Renault team brake bias system, Ferrari fuel system and power unit investigation and the Mercedes Dual-Axis Steering (DAS) system. It is emphasized that the elimination of gaps in legal regulation is carried out not only by adding or changing Technical Regulations, but also by issuing technical directives that are not subject to official publication. The author carries out a comparative analysis of the legal properties of Technical Regulations and technical directives with acts of secondary law of the European Union with similar titles (regulation and Directive) is carried out.
Intellectual Property as a Legal Mechanism Accompanying the Fight against the Pandemic in the context of the Spread of Coronavirus Infection (COVID-19)
Authors: Shakhnazarov B. A.
Published: August 2020

The paper examines the legal problems of protection and use of intellectual property in the context of fighting the pandemic. It is noted that the recommendations proposed by the World Health Organization to identify, diagnose and isolate, as well as to provide assistance to patients with suspected coronavirus infection in a pandemic can be effectively implemented only with proper legal regulation of the protection of intellectual property rights to the relevant results of intellectual activity, stimulating relevant developments while maintaining a balance between private and public interests. The paper examines the modernization of Russian legislation in the sphere of relations under consideration. Of vital importance are developments related to medicines and medical devices in preventing and overcoming the consequences of the spread of infectious diseases; flexibility of the legislator and the need to implement special-simplified, accelerated-legal regimes for the introduction of medicines and medical devices into trade. The author summarizes regulations at the interface of the legislation on circulation of medicines and intellectual property law in Russia and abroad (USA, Germany), as well as at the supranational level (EAEC). In modern conditions, the possible rapid spread of viral infections and pandemic threats it is essential to establish the legal basis for the balance between the public interest and the interests of patent holders in national legislations, based on a harmonizing international treaty provisions. The authors considers the restriction of patent rights in the extreme urgency with the obligatory non-exclusive and temporary nature of the use of objects of patent rights by a third party based on such restrictions and the mandatory payment of a just compensation to patent holders together with accelerated and simplified mechanisms for registration and introduction into the turnover of the relevant medicines, including vaccines, be a justified and necessary tool to combat the pandemic and the best means of overcoming its consequences.
“Everything you do is giving them feedback”: A phenomenographic study of teacher conceptions of feedback
Authors: Harris Lois R. , Brown Gavin T. L.
Published: August 2020

Teachers often provide or set up opportunities for feedback within classroom contexts. How they understand what feedback is and how it should be given is essential to their feedback practices. Since feedback is commonly a communicative exchange between teacher and students or students and their peers, it is essential to understand teacher conceptions about feedback. This study explored 18 teachers’ conceptions of feedback and how they were enacted. Phenomenographic analysis identified five hierarchically ordered feedback conceptions associated with three major purposes, that is: i) satisfying stakeholder expectations, ii) maintaining student psycho-social wellbeing, and iii) supporting learning growth. Teachers experienced significant tensions among these three functions, highlighting the importance of ensuring that teacher concerns for student emotional wellbeing do not undermine feedback for academic improvement purposes. Likewise, the study points to the importance of aligning system policies and expectations around feedback with teacher beliefs.
Safety in schools during COVID-19, and its implications for democratic education
Authors: Estellés Marta , Bodman Holly
Published: August 2020

During the COVID-19 pandemic, calls to protect children and young people have proliferated in educational contexts, consolidating safety as a core principle guiding an increasing number of decisions at schools. Recently, however, more and more scholars have begun to question the ambiguous nature of “safety”, analysing the tensions between this concept, education, and children’s citizenship. The purpose of this article is to problematise the political and educational implications created by concerns about safety in the unprecedented times of COVID-19. Using Apple and Beane’s (2007) classic work on democratic education, our study delves into the educational experiences of nine educators and eight students in Aotearoa New Zealand during COVID-19 to explore their uses of safety. Our findings highlight the nuanced ways in which the discourses of safety can lead to curricular and pedagogical practices of comfort, isolation, and control.
Inhibition of Colorectal Cancer Cell Line CaCo-2 by Essential Oil of Eucalyptus camaldulensis Through Induction of Apoptosis
Authors: Taheri Elham , Ghorbani Saba , Safi Maryam , Seyyed Sani Nasrin , Firouzi Amoodizaj Fatemeh , Heidari Masoud , Chavoshi Reza , Hajazimian Saba , Isazadeh Alireza , Heidari Mansour
Published: August 2020

Treatment of colorectal cancer is one of the important challenges due to the increase of resistance to chemotherapeutic drugs. Isolated natural compounds from medicinal plants and other sources often are used as novel drugs for treatment of various human cancer. The aim of this study was to investigate the antioxidant and anticancer activity of Eucalyptus camaldulensis essential oil on colorectal cancer cell line Caco-2. The antioxidant activity of extracted E. camaldulensis essential oil (1000, 800, 400, 200, 100, 50, 25, 12.5, 6, and 3 μg/mL) was evaluated by free radicals inactivation method. Moreover, MTT assay was used to examine the cytotoxic effects of E. camaldulensis essential oil on the Caco-2 cell line. The mRNA expression of BAX and BCL-2 genes was studied using quantitative Real-Time PCR method, in treated cancer cells compared to untreated cells. We indicated a significant, impressive antioxidant activity in 1000 μg/mL of E. camaldulensis essential oil, in a concentration-dependent manner. In addition, we found that this product exerted a cytotoxic effect on cancer cells when 100 μg/mL concentration was considered as half-maximal inhibitory concentration (IC50). Also, the expression of BAX and BCL-2 genes were significantly upregulated and downregulated, respectively, in the treated Caco-2 cells with E. camaldulensis essential oil. In conclusion, our study showed significant antioxidant and anticancer activity in E. camaldulensis essential oil in a concentration and time-dependent manner, which may be due to the reduction of free radicals and induction of apoptosis process in colorectal cancer cells.
The Association of Extravasated Platelet Aggregation With Clinical Futures in Patients With Colorectal Cancer and Its Correlation With EMT Markers
Authors: Ahmadiankia Naghmeh , Yarmohammadi Maryam , Hadi Azam , Jafari Behnaz , Fazli Mozhgan , Shahmohammadi Zahra
Published: August 2020

The theory of platelet role in cancer progression was recently introduced. We investigated the association of extravasated platelets in colorectal cancer with clinicopathological features, and also the expression of epithelial-mesenchymal transition (EMT) markers. We retrospectively analyzed data from 33 patients with colorectal cancer who underwent surgery between 2013-2016. In formalin-fixed paraffin-embedded tissues, we evaluated the expression of a platelet-specific marker of CD42b and EMT markers using immunohistochemistry. The associations among the expression of the platelet‑specific marker in specimens, EMT, and clinicopathological futures were analyzed. The presence of platelets was observed in 15 out of 33 primary colorectal tumors (45%). According to multivariate analysis, CD42b expression was not correlated with clinical characteristics. Platelet-positive tumor cells did not show EMT marker expression. These data suggest that extravasated platelets may not have a central role in determining patient characteristics and clinical futures.
Epidemiology of Traumatic Injuries in the Elderly Patients: A Descriptive Study From a Developing Country
Authors: Panjavi Behnam , Shakiba Saeed , Afshari Khashayar , Yousefi Farbod , Mehrpour Saeed Reza , Najafi Mohammad Sadeq , Nabian Mohammad Hossein
Published: August 2020

The epidemiology of traumatic injuries in elderly patient fractures varies widely among countries. There is quantitative information to determine the prevalence and gender/age distribution of traumatic injuries in the elderly patient. The aim of the current study was to reveal the prevalence and age and gender distribution of various traumatic injuries in an elderly patient refers to as a tertiary orthopedic hospital in Iran. In a prospective descriptive study, all elderly patients with traumatic injuries attending the Orthopedic Trauma Unit of our center in 2001-2011 were included. Demographic details, the cause of injury, injury classification was recorded. For each gender, we calculated the numbers with fractures, dislocations, soft tissue injuries, ligamentous injuries, and lacerations and derived average age and gender-specific prevalence. During a period of 10 years, a total of 1172 elderly patients were admitted, 588 (50.1%) males, and 584 (49.9%) females. 849 patients (72.4%) had fractures. 323 (27.5%) of the patient had other limb injuries were include soft tissue injuries, lacerations, ligamentous injuries, and dislocations. The three most common fracture sites were proximal femur (40.02%), distal radius/ulna (12.47%), and proximal humerus (6.53%). The most prevalent traumatic injury among the elderly was fractures with a higher rate in females. The most common fracture sites were proximal of the femur and distal of radius and ulna bones.
Epidemiological study designs- Examples of medical sciences
Authors: Askari Maryam , Mahmoudi Kohani Hassan ali , Namiranian Nasim
Published: August 2020

This article is a Letter to Editor and does not include an Abstract.
Comparison of CFT- ACT Combined Therapy with CBT on Psychological Well- Being in Diabetic Women
Authors: Khayatan Shahin , Aghaei Asghar , Abedi Mohammadreza , Golparvar Mohsen
Published: August 2020

Objective: The purpose of this study was to compare the effectiveness of compassion focused (CFT) and acceptance commitment (ACT) combined therapy with cognitive-behavioral therapy (CBT), on psychological well-being in women with type 2 diabetes (T2DM).
Materials and Methods: This is quasi-experimental. This study consists of three groups (two experimental and one control groups) and three stages (pre-test, post-test, and follow up). The statistical population was all T2DM women of Shahid Shabani Diabetes Center in Isfahan, Iran in 2017. The studied sample was 47 patients who were randomly distributed in three groups. The experimental group received a combination of the package of ACT and CFT for ten weekly two-hour sessions, the CBT group received ten weekly two-hour sessions of therapeutic intervention and the control group did not receive any therapeutic interventions. Data were analyzed by analysis of variance with repeated measurements using SPSS-24 software.
Results: The results showed that the scores of experimental groups participants in the post test of compassion therapy-ACT and CBT improved significantly compared to the control group in self-acceptance, positive relationships with others, purposeful life, individual development, environmental dominance and autonomy subscales (P-value= 0.001) .There exist a significant difference  between the experimental group of compassion focused- ACT combined therapy and CBT in self-acceptance, positive relationships with others, purposeful life and individual -development  subscales (P-value< 0.001).
Conclusion: Based on the findings, the combination therapy of compassion focused – ACT and CBT can be used to promote psychological well-being in diabetic patients.
The Effect of 12 Weeks Aerobic Training on PDX-1 and GLUT2 Gene Expression in the Pancreatic Tissue of Type 2 Diabetic Rats
Authors: Sokhanvardastjerdi Shokoufeh , Banaeifar Abdolali , Arshadi Sajad , Zafari Ardeshir
Published: August 2020

Objective: The aim of this study was to investigate the effect of 12 weeks aerobic training on PDX-1 and GLUT2 gene expression in the pancreatic tissue of type 2 diabetic rats.
Materials and Methods: 21 wistar male rats were placed in 3 groups (healthy, diabetic, aerobic diabetic). Diabetes was induced by peritoneum injection of nicotine amid. Training program lasted 12 weeks, five sessions per week by gradual increase of speed (18 to 26 meters on minutes) and time (10 to 55 minutes) in the form of running on the treadmill. After 12 week aerobic training, PDX-1 and GLUT-2 genes were measured. Data was analyzed using ANOVA with 5 % significance level.
Results: Aerobic training caused a significant increase in the expression of GLUT2 (P-value: 0.043) and PDX-1 genes (P-value: 0.007) in the pancreatic tissue of rats with type 2 diabetes (p value: 0.05). Also aerobic training had a significant effect on serum glucose (P-value: 0.001) and insulin levels (P-value: 0.001).
Conclusion: It is concluded that aerobic training has significant effects on diabetic control by increasing the expression of PDX1 and GLUT-2 which lowers serum glucose.
The Effect of Interval and Continuous Training on Angiogenesis Factor in Type2 Diabetic Wistar Rats
Authors: Shahidi Fereshteh , Yazdani Faramarz , Gaeini Abbas Ali
Published: August 2020

Objective: The equilibrium of angiogenesis stimulus agents and angiogenesis inhibitory agents is an important factor in the increase of diabetic cardiomyopathy. This research aimed to survey the result of eight weeks of high-intensity interval training (HIIT) and moderate continuous (MICT) on the myocardium angiogenesis agent and histological alterations within male diabetic rats.
Materials and Methods: 32 male Wistar rats did casually selected within 4 groups: health without exercise control, diabetic without exercise (D), D + HIIT, and D+ MICT groups. Diabetes type 2 produced with high-fat food for two weeks and an only dose of STZ. After approval of type 2 diabetes, subjects did direct to HIIT (90 -95 percent of VO2max), and MICT (50 to 65 percent of VO2max) exercise program five times per week during eight weeks. Western blotting methods were utilized for the exposure of protein synthesis of Vascular Endothelial Growth Factor (VEGF), Transforming Growth Factor-beta (TGF-β1), and Matrix Metalloproteinase-9 (MMP9) in the left ventricle. Besides, the base and ultimate blood glucose were estimated. Histological alterations assessed utilizing H&E and Masson’s trichrome staining.
Results: The installation of diabetes develops TGF-β1 (P-value= 0.001) and reduces MMP9 (P-value= 0.002) and VEGF (P-value= 0.002). But, eight weeks of MICT enhanced MMP9 (P-value= 0.002) and VEGF (P-value= 0.002), but the volume of TGF-β1 (P-value= 0.001) diminished significantly. Furthermore, the MICT did improve better than of HIIT in improving angiogenesis agents and adjust body mass, plasma glucose in the rats with diabetes.
Conclusion: Not only eight weeks of interval and continuous exercise enhanced levels of MMP9 and VEGF, but also revealed a notable reduction in TGF-β1. Additionally, both training diminishes body weight and blood sugar.
Expert Role of Regional Museum for the Projects of Public Spaces Improvement
Authors: Ladygina Tatyana , Belyaeva Maria
Published: August 2020

This article considers the experience of improving public spaces of one of the small towns in Sverdlovsk region – the city of Krasnoufimsk. The topic of urban improvement is a serious challenge for our country. When designing public areas, it is important to consider the features of the city, its history, uniqueness, opinion of the population. Several tasks can be solved through the improvement of the city: the development of a comfortable urban environment, attracting tourists and preserving the cultural heritage. The choice of certain landscaping projects in most cases requires historical and cultural examination. Cultural workers should also act as experts in the public space reconstruction project. This article reflects on a similar experience during the reconstruction project of the Ufa river embankment in the central district of Krasnoufimsk, when employees of the regional museum were invited to participate. The text presents examples of filling the space of the embankment with hidden meanings from the regional history. The authors are of the opinion that representatives of museum community in modern society are not only keepers of the past, but also creators of the future image of the city.
Keywords: public spaces, urban landscaping, small town, cultural heritage, historical and cultural expertise, local history museum
Stone Cutting in the Urals: Towards the Question of Regional Cultural Features
Authors: Alieva Olga , Sokolov Maxim
Published: August 2020

This study considers the phenomenon of the Ural school of artistic processing of colored ornamental stone as an educational process. Education in the field of stonecarving art in the Urals, despite following the all-Russian principles for the development of an art school, is a unique phenomenon, due to geographical and socio-cultural factors. The training of stone cutters arose along with the need to process stone directly in the vicinity of material extraction. The educational process was developed in the Soviet era as a means to gather personnel for stone-cutting production. More recently, the development of this artform has produced a new approach in the education of specialists in the artistic processing of stone. Both the traditions of the educational process and the problems of today are examined, revealing the general picture of the development of the trend. The study, regarding the development of a separate direction of the educational process, will supplement and concretize the general picture of the development of not only the Ural, but also the domestic art school.
Keywords: educational process, Ural stone-cutting school, artistic processing of colored ornamental stone, educational institution
Glass Artworks of the Naive Artist Albert Korovkin
Authors: Bobrikhin Andrey
Published: August 2020

Naïve art is still under-represented in Russian museum and professional art institutions, with the works and heritage by many artists remaining under-exhibited and underresearched. Albert Korovkin (1935) is an artist whose name features in the World Encyclopaedia of Naive Art. His works entered the collection of the Yekaterinburg Museum of Fine Arts as part of the gift from Yevgeny Roizman. Among the donated works, there were about 50 pieces of glass-blowing art. Korovkin worked as a glassblower at the Institute of the Ural Scientific Centre, where he manufactured scientific equipment, but did not have a professional glassblower education. Since the collector did not register attribution data at the time of the acquisition of works, any information on the technology of manufacturing works, as well as a comparative analysis of the series of paintings and glass-blowing works, is relevant. This article presents an attempt of such an analysis providing relevant information on the artist’s background, style and technique.
Keywords: amateur art, artistic glass, glass-blowing technique, glass staining
The Cultural Phenomenon of Artworks in Hot Enamel Technique
Authors: Berkovich Olesya
Published: August 2020

The article explores the phenomenon of the emergence of artistic enamel as a medium for standalone easel works during the Soviet and later Russian period in contemporary Russian history, tracing the historical development of this art throughout several decades of the twentieth and twenty-first centuries and explores its origins and perspectives. The work of outstanding Russian enamel artists, founders of different schools of hot enamel, which influenced the formation and development of the author’s artistic enamel is highlighted. This analysis demonstrates the potential of the hot enamel technique in a wide range of artistic works, both in its dimensions (from miniature to monumental works) and its range of subjects and styles. Hot enamel has proven itself to be a versatile medium and is being embraced by creative artists in search of new materials and techniques. Hot enamel in Russia was influenced both by international artistic developments and by Russian trends and stylistic explorations, finding inspiration in other types of art and the contemporary art scene.
Keywords: hot enamel, phenomenon, artistic enamel, decorative art
Safety of health providers in the physical handling of patients in nursing care
Authors: Zeman Marek , Treslova Marie
Published: August 2020

This article is a Letter to Editor and does not include an Abstract.
Nursing students’ willingness to care for older adults in Turkey in 2020
Authors: Toygar İsmail , Hançerlioğlu Sadık , Theofanidis Dimitrios
Published: August 2020

Background & Aim: The population of older adults is dramatically increasing in the world. This increase results in more demand for health care services from older adults. So, nurses’ and nursing students’ willingness to care for older adults gain importance. The aim of the study was to determine the willingness of nursing students to care for older adults and the factors affecting this in Turkey.
Methods & Materials: This descriptive cross-sectional study was conducted between November-December 2019 in the nursing faculty of a public university. 299 students were randomly selected and data were collected by using a demographic student form and the Willingness to Care for Older People scale. Data were analyzed via the SPSS version 25 program.
Results: The great majority (90.3%) of the students were female and the mean age was 21.3±1.2 years. The mean score of the students' willingness to care for the elderly was 36.82±5.96. The willingness to care for the older adults was found to be affected by caring for the older adults in clinical practice (B=2.136, β=0.174, p=0.008) and wanting to live with an elderly relative (B=2.022, β=0.168, p=0.016).
Conclusions: The experience of caring for an older adult in clinical practice and to be willing to live with an older relative in the same house is positively associated with the willingness of student nurses to consider geriatric nursing as an option.
An Eligible Surgical Repair Technique for Bland-White-Garland Syndrome
Authors: ECEVİT Ata Niyazi , DİKMEN YAMAN Nur , ARICI Burcu , EYILETEN Zeynep , KAYA Bülent , UYSALEL Mustafa Adnan
Published: August 2020

Anomalous origin of left coronary artery from pulmonary artery (ALCAPA) is an uncommon but major congenital cardiac anomaly, which was firstly defined in 1866. Multiple surgical techniques intend to compose 2-coronary artery system, including direct reimplantation of left coronary artery to aorta and coronary artery bypass grafting procedures. Left coronary artery seldomly rises from non-facing pulmonary sinus, where direct reimplantation is technically quite difficult for surgical correction because of long distance from native aorta. In this case report, a surgical technique option of reconstructing left coronary artery, arising from non-facing sinus which we turned to aorta with a tunnel created from autologous pulmonary artery wall, was presented.
Rectum Perforation Secondary to the Enema with Garden Hose: A Case Report
Authors: GÖNÜLLÜ Mehmet Emin , ÖZAYDIN İsmet
Published: August 2020

A 73-year-old male patient was admitted to the emergency department with severe abdominal pain. It was thought that the patient might have colon perforation with the patient’s history, physical and radiological examination. In the patient’s history; since his youth, it was understood that when he has been constipated, he has made an enema with tap water by attaching the garden hose into the rectum and connects the other end to the fountain. In this case report, we wanted to present the colon perforation during the hose penetration, and peritonitis of the patient who had foreign body penetration chronically into the rectum with the purpose of making enema periodically, and the operation performed after. Since our patient was a delayed case, we quickly initiated resuscitation, prophylactic antibiotherapy, and underwent protective colostomy in our operation. We think that colostomy reduces the mortality and morbidity in delayed cases.
Clinicopathologic Features of Phyllodes Tumor in Breast
Authors: KARAGÖZ EREN Saliha , DÖNDER Yunus , ERTAN Tamer , AKAY Ebru , ARSLAN Alaettin
Published: August 2020

Aim: Phyllodes tumors are rare breast neoplasms comprising less than 1% of all breast neoplasms. The objective of this study was to consider the clinicopathological features of phyllodes tumors that underwent surgery in our hospital.Material and Methods: We retrospectively analyzed the medical records of 16 patients who had histologically diagnosed phyllodes tumors over 9 years.Results: There were 16 female patients with a mean age of 45.6±15.3 years. Magnetic resonance imaging was performed in 5 cases for preoperative diagnosis, and 4 were reported as phyllodes tumors, all of these patients were having high-grade phyllodes tumors (borderline or malignant) histopathologically. Preoperative core biopsy was performed in 14 patients, and histopathologically phyllodes tumor was diagnosed in two patients. In six patients, differentiation between hypercellular fibroadenoma and phyllodes tumor could not be performed. Breast-conserving surgery was the most common type of operation performed in 10 (62.5%) patients, three patients with positive margins were underwent reoperation. The pathological diagnoses were benign, borderline, and malignant in seven (43.8%), five (31.3%) and four (25.0%) patients, respectively. The median diameter of the tumors was measured as 6 cm after the postoperative pathological analysis. The median follow-up time was 36 months. During this time, there was no local or systemic recurrence.Conclusion: Wide excision with a clear margin appears to be the most important factor in the management of these tumors and in the prevention of local recurrence. The preoperative diagnosis of phyllodes tumors contributes to decreasing the necessity for secondary surgical intervention avoiding border positivity.
Comparison of Type I Diabetes Frequency in Children with Cesarean and Normal Vaginal Delivery
Authors: ŞAHİN İbrahim Ethem , HACIOĞLU Ceyhan , ALPAY Merve , KİLİÇASLAN Önder
Published: August 2020

Aim: The effect of type 1 diabetes mellitus over the world is rising day after day. There are controversial results that may be related to cesarean delivery that has become widespread in recent years and the risk of type 1 diabetes mellitus. In this study, we aimed to investigate the frequency of type 1 diabetes mellitus in children born by cesarean delivery or normal vaginal delivery, considering that there may be an association between mode of birth way and diabetes mellitus.Material and Methods: The study was organized with 368 children who were diagnosed as type 1 diabetes mellitus between 8-16 ages that applied to the diabetes outpatient clinic in 2019. The patients were grouped according to the mode of delivery. Descriptive data such as age, gender, HBA1c, and BMI were evaluated retrospectively.Results: The children with type 1 diabetes mellitus, cesarean delivery show 33.2% more than normal vaginal delivery (p<0.001). While 9.0% of children with cesarean delivery had mother's diabetes mellitus, this rate was 5.7% in children with normal vaginal delivery. Similarly, 5.3% of children with cesarean delivery had diabetes mellitus in their father, while this rate was 8.9% in children with normal vaginal delivery.Conclusion: According to the results of this study, cesarean delivery may have a significant effect on the risk for type 1 diabetes mellitus in childhood either adolescence. Even if parents with diabetes were not included, it was found that cesarean delivery have meaningful relation by diabetes mellitus stimulation. Regarding this, further studies are needed.
Interstitial Lung Disease due to Quetiapine: Case Report and Literature Review
Authors: TOPCUOĞLU Müge , ERDOĞAN Ali
Published: August 2020

Quetiapine is a commonly used antipsychotic drug which has many common side effects such as dizziness, sedation, and metabolic side effects. In addition to them, the drug has also some rare side effects. Among them, little is known about drug-induced interstitial lung disease (DI-ILD). In this case report, we aimed to discuss the side effects of quetiapine use on the lung. We present a case of interstitial lung disease, which is rare side effect, that occurred following quetiapine use in a 54-year-old male schizophrenia patient. In our case, DI-ILD was examined due to the lung findings that occurred after quetiapine treatment started and regressed after quetiapine cessation. Clinicians should be careful about rare lung side effects such as DI-ILD that may develop as a result of quetiapine use.
The Prediction of Allergic Proctocolitis by Using Hematological Parameters
Authors: ÇAM Sebahat
Published: August 2020

Aim: Allergic proctocolitis (AP) is a common cause of rectal bleeding in infants. There is no diagnostic tool specific to the disease. The aim of the study was to evaluate hemogram parameters as a marker of inflammation in patients with AP.Material and Methods: The files of patients who were exclusively breastfed and diagnosed as food protein induced AP were examined retrospectively. A hundred and fifty patients diagnosed with AP were included in the study. The same number of healthy babies formed the control group. Parameters in complete blood count were compared between patient and control groups. Rectosigmoidoscopic examination was performed to confirm the diagnosis in patients who could not achieve complete improvement with diet therapy, and hemogram parameters were evaluated according to eosinophilic infiltration in biopsies.Results: The mean platelet volume (MPV) values (p<0.001) and eosinophil percentages (p=0.001) of the AP group were higher than the control group. The mean hemoglobin values of the AP group were statistically significantly lower than the control group (p<0.001). No statistically significant difference was found between patient and control groups in terms of white blood cell (WBC) count, platelet count, platelet distribution width (PDW) and neutrophil/lymphocyte ratio (NLR). WBC count, platelet count, hemoglobin, MPV and C-reactive protein (CRP) values were similar between groups of patients according to the number of eosinophils in colon biopsies.Conclusion: We observed a significantly higher MPV values and eosinophil percentages in patients with AP. These parameters maybe helpful in diagnosis of AP.
Characterization of strawberry associated fungi and in vitro antagonistic effect of Trichoderma harzianum
Authors: Morales-Mora Luis Angel , Andrade-Hoyos Petra , Valencia-de Ita M. Angeles , Romero-Arenas Omar , Silva-Rojas Hilda Victoria , Contreras-Paredes Carlos A.
Published: August 2020

México es el tercer productor de fresa a nivel mundial, donde la producción de este cultivo es de importancia económica y generación de divisas en el pais. El objetivo de la presente investigación fue identificar y caracterizar morfológicamente los hongos asociados a enfermedades en un cultivo de la fresa, así como determinar la capacidad antagónica in vitro de la cepa T-H4 de Trichoderma harzianum con los hongos identificados. Se colectaron muestras de plantas del cultivo de fresa con síntomas de enfermedades fúngicas, se sembraron en medio PDA y se generaron cultivos monospóricos para su caracterización morfológica. Los hongos identificados y la cepa T-H4 se confrontaron mediante cultivos duales. Se identificaron tres hongos asociados al fruto (A. niger, Colletotrichum sp. y R. stolonifer), tres en hojas y tallo (Pestalotiopsis sp., Curvularia sp. y Alternaria sp.) y dos hongos asociados a la raíz (Rhizoctonia sp. y Fusarium sp.). La cepa T-H4 presentó un nivel antagónico adecuado para Colletotrichum sp., Pestalotiopsis sp., Alternaria sp., Rhizoctonia sp. y Curvularia sp., in vitro. Se sugiere realizar evaluaciones de control biológico con estos aislamientos en invernadero y a campo abierto, así como determinar su patogenicidad.
Karabük Demir Çelik Fabrikası'nda çalışan işçilerin yaşam kalitesi ve ilişkili faktörler: kesitsel araştırma
Authors: ÖZDEMİR Raziye , DEMİR Çiğdem
Published: August 2020

Amaç: Karabük Demir Çelik
Fabrikası’nda (KARDEMİR) çalışan işçilerin yaşam kalitesinin ve ilişkili
faktörlerin değerlendirilmesi amaçlandı.Yöntem:
Kesitsel tipteki çalışma, KARDEMİR’de 2016-2017 yıllarında gerçekleştirildi.
Çalışmada 1016 işçiden elde edilen veri
değerlendirildi. Veri toplama aracı olarak işçilerin bireysel, sosyodemografik
ve iş ile ilgili özellikleri sorgulayan bir soru formu, Dünya Sağlık Örgütü
Yaşam Kalitesi Ölçeği Kısa Formu-Türkçe Versiyonu ve İsveç İş
Yükü-Kontrol-Destek Anketi-Türkçe Versiyonu kullanıldı. Veriler, ki-kare testi
ve binary lojistik regresyon aracılığı ile analiz edildi. Bulgular: İşçilerin yaşam kalitesi ölçeğinden aldıkları ortalama puanlar fiziksel
alan için 15.0±2.5, psikolojik alan için 15.1±2.5, sosyal alan için 15.0±3.0,
çevre alanı için 13.9±2.5 ve ulusal çevre alanı için 13.6±4.0 idi. Bekar olma,
düşük öğrenim düzeyi, sigara kullanımı, düşük veya normal beden kitle indeksi,
kronik hastalık varlığı, aylık gelirin geçimini sağlamak için yeterli olmaması,
iş güvencesi açısından kaygı duyma, yüksek iş stresi ve düşük sosyal destek
düzeyi, işçilerin ölçekten aldıkları puanları düşürüyordu.

Sonuç: İşçilerin yaşam
kalitesinin iyileştirilmesi için sigarayı bırakma gibi sağlığın
geliştirilmesine ve psikososyal risk etmenlerinin ortadan kaldırılmasına
yönelik müdahaleler planlanmalıdır.
Electrochemical Analysis of Sulfamethoxazole by Differential Pulse Voltammograms Method
Authors: Alkhawaldeh Ahmad Khalaf
Published: August 2020

Manganese and Molybdenum oxides are well-known electro-catalysts in fuel cells systems; they are usually used as anodic materials for the oxidation of low molecular weight alcohols. The utilization of MoO2 and MnO2 as catalysts in the pharmaceutical analysis is not common yet an analytical method for the determination of Sulfamethoxazole (SMX) antibacterial agents in Pharmaceutical Dosage form is developed. The method is based on the voltammetric determination of SMX using modified glassy carbon electrode by molybdenum oxide. The two components are oxidized at the modified electrode surface with the development of current that is linearly proportional to their concentrations in the range of 7.04*10-7- 1*10-3 M for SMX. The oxidation reaction of the two components is pH-dependent, in which the buffer used is Britton-Robinson at pH = 7.00 where maximum peak current and maximum peak separation is obtained. The regression factors obtained from the calibration curves are 0.9790 for SMX and 0.9812 for TMP. The method of analysis was validated, where the limit of detection (LOD) and the limit of quantitation (LOQ) of SMX were calculated to be 1.44*10-4 M, 4.36*10-4 M and 1.27*10-4 M, 3.84*10-4 M respectively, The percentage recovery of both components was also calculated to 81 % for SMX.
A visual tool inclusive of fetal ultrasound and autopsy findings to reach a balanced approach to counselling on trisomy 18 in early second trimester
Authors: Triunfo Stefania , Bonollo Marta , Gaffuri Priska , Viviano Manuela , Satta Daniele , Bergmann Manuela
Published: August 2020

Identified by the eponym “Edwards’ Syndrome,” trisomy 18 (T18) represents the second most common autosomal trisomy after T21. The pathophysiology underlying the extra chromosome 18 is a nondisjunction error, mainly linked with the advanced maternal age. More frequent in female fetuses, the syndrome portends high mortality, reaching a rate of 80% of miscarriages or stillbirths. The three-step evaluation includes first trimester screening for fetal aneuploidy using a combination of maternal age, fetal nuchal translucency thickness, fetal heart rate and maternal serum free ß-hCG and PAPP-A; followed by the research for fragments of fetal DNA in maternal blood; and, finally, invasive techniques leave to the established diagnosis. Starting with the first trimester scan, selected ultrasound findings should be investigated to define not only the impact of the genetic problem on the fetus, but also to address the prenatal counselling. Previous series underline that T18 is not uniformly lethal. An active dialogue on the choices in the management of infants with T18 has emerged, sustained by the transition from the comfort care to the intervention attitude. Survival rates for individuals with supposedly fatal conditions have increased. In this novel scenario, an ad hoc counselling is pivotal. To support it, a comparative analysis by pictorial assays between ultrasound and autopsy findings could be beneficial. We provide an illustrative tool from a clinical case managed in early second trimester, with the purpose to strive a balanced approach in the hard choice faced by couples of fetuses with T18.
Intra-Rater Test-Retest Reliability of Self-Reported Child Functioning Module
Authors: Ng Kwok , Asunta Piritta , Leppä Niko , Rintala Pauli
Published: August 2020

Determining disability prevalence is an important area for population statistics, especially among young adolescents. The Washington Group on Disability Statistics is one source of reporting disabilities through functional difficulties. However, young adolescents self-reporting this measure is in its infancy. The purpose of this study was to carry out an intra-rater test-retest reliability study on a modified set of items for self-reporting functional difficulties. Young adolescents (n=74; boys=64%; age m=13.7, SD=1.8) completed a self-reported version of the child functioning module in a supervised classroom. The second administration took place two weeks later. Intraclass correlation coefficient (ICC) and Kappa (k) statistics were used to test reliability of the items, and interpretation through Landis & Koch, and Cohen, respectively. The majority of items had substantial or moderate agreement, although there was only fair agreement for self-care (ICC=0.59), concentration (ICC=0.50), and routine (ICC=0.54). Kappa statistics of behaviour were interpreted to be large (k=0.65), and seeing (k=0.49), walking (k=0.49), and speaking (k=0.49) difficulties were moderate. The majority of the items in the self-reported version of the child functioning module can be used in a scale format, although some caution may be required on items of self-care and concentration when used as a dichotomous variable.
Potensi Pemanfaatan Kearifan Lokal untuk Menahan Konversi Lahan Sawah ke Nonsawah
Authors: Septanti Kartika Sari , Saptana NFN
Published: August 2020

Lowland conversion to non-agriculture use improves along with economic growth. Various attempts have been exerted by the government to reduce lowland conversion. Local wisdoms throughout the regions in the country are potential to control lowland conversion. This paper aims to explore the role of local wisdoms in Indonesia and other countries in controlling lowland conversion. Some local wisdoms in Indonesia potentials for lowland conversion control are : tunggu tubang, mundang biniak, oloran sawah, Suku Samin, Buyut Cili, tradisi Ngarot, Kasepuhan Sinar Resmi, Suku Baduy, Subak, Suku Dayak, and pangale hutan. Some measures to take for empowering those local wisdoms, are: (i) incorporating local wisdoms into school education curriculum; (ii) developing a community-based natural resource management system, namely increasing participation of local people in land resource management.

 

Abstrak

Konversi lahan sawah ke nonsawah marak terjadi seiring pesatnya pertumbuhan ekonomi. Berbagai upaya telah dilakukan pemerintah untuk menekan laju konversi lahan sawah ke nonsawah, namun belum menunjukkan hasil yang optimal. Indonesia memiliki kekayaan kearifan lokal yang tersebar di seluruh nusantara yang berpotensi menghambat tingginya laju konversi lahan sawah ke nonsawah. Tulisan ini membahas kearifan lokal di Indonesia serta di beberapa negara yang telah dan akan dikembangkan untuk mempertahankan lahan sawah. Beberapa contoh kearifan lokal di Indonesia antara lain: tunggu tubang, mundang biniak, oloran sawah, Suku Samin, Buyut Cili, tradisi Ngarot, Kasepuhan Sinar Resmi, Suku Baduy, Subak, Suku Dayak, dan pangale hutan. Tantangan kearifan lokal pada masa depan semakin berat karena adanya pertumbuhan jumlah penduduk, pertumbuhan ekonomi, serta perubahan sosial masyarakat yang mendesak lunturnya nilai-nilai kearifan lokal. Beberapa strategi untuk mempertahankan kearifan lokal dapat dilakukan dengan cara: (1) memasukkan ke dalam kurikulum pendidikan;  (2) mengembangkan sistem pengelolaan sumber daya alam berbasis komunitas, yaitu peningkatan partisipasi masyarakat lokal dalam pengelolaan sumber daya lahan.
Percutaneous-perventricular device closure of ventricular septal defect: mid-term follow-up.
Authors: Wang Long , Xie Lin , Ruan Weiqiang , Li Tao , Gan Changping , Lin Ke
Published: August 2020

Background: This report presents updated data and mid-term follow-up information to a former study introducing the novel technique of percutaneous-perventricular device closure of doubly committed subarterial ventricular septal defect. Methods: Thirty-eight patients were added to the former series. There were 54 patients in total who had isolated doubly committed subarterial ventricular septal defects and underwent percutaneous-perventricular device closure. Closure outcomes and possible complications were measured in the hospital and during the 2.5-year follow-up. Results: Surgery was successful in 53 patients (98.1%). There was no death, residual shunt, new valve regurgitation or arrhythmia either perioperatively or during the entire follow-up period. Only one patient developed pericardial effusion and tamponade in the former series. The mean hospital stay was 3.2±0.6 days (range, 3.0 to 6.0 days), and only one unsuccessful case needed blood transfusion (1.9%). Conclusions: The percutaneous-perventricular device closure of isolated doubly committed subarterial ventricular septal defects appeared to be safe. Close monitoring for bleeding is essential postoperatively, especially in younger patients. This technique is generally safe with acceptable mid-term follow-up.