bluuebunny/crossref_metadata_2025 huggingface dataset:
Complicații materno-fetale în infecția pandemică cu virusul SARS-CoV 2 | [Maternal-fetal complications in pandemic infection with SARS-CoV 2 virus]
Authors: Casap Stela , Badila Sabina , Ciobanu Natalia , Feștilă Dana , Moga Marius Alexandru
Published: March 2024

Introduction: The pandemic caused by the SARS-CoV-2 virus is a challenge for global health systems and generates problems both at socio-economic and individual levels. Objectives: The aim of the study was the general presentation of viral pathogenesis, its transmissibility, and maternal-fetal complications that occur following SARS-CoV-2 virus infection that have been identified in the literature and its prevention. Results: This paper is a systematic review that includes a summary of the literature using the PubMed database with a selection of studies from January 2020 to July 2022. Many studies have reported a slightly increased severity of COVID-19 among pregnant women compared to non-pregnant women due to complications during pregnancy that resulted in miscarriages, premature births, or preeclampsia. Conclusion: Therefore, further investigations are needed to elucidate how COVID-19 affects pregnant women and newborns as well as the long-term impact of SARS-CoV2 infection on women who have given birth, regardless of immunological status at birth.
Rezumat
Introducere: Pandemia cauzată de virusul SARS-CoV2 reprezintă o provocare a sistemelor de sănătate globale și generează probleme atât în context socio-economic cât și la nivel individual. Obiective: Scopul studiului a fost prezentarea generală a patogenezei virale, a transmisibilității acestuia și complicațiilor materno-fetale ce survin în urma infecției cu virusul SARS-CoV2 ce au fost identificate în literatura de specialitate și modalitatea de prevenție a acestora. Rezultate: Această lucrare este o revizuire sistematică ce include un rezumat al literaturii de specialitate utilizând baza de date PubMed cu selecție a studiilor clinice cuprinse în perioada Ianuarie 2020- Iulie 2022. Această revizuire a literaturii are limitări datorită cohortelor mici și a datelor insuficiente legate de patogeneza și complicațiile materno-fetale asociate infecției cu virusul SARS-CoV2. Concluzii: Prin urmare, sunt necesare investigații suplimentare pentru a elucida modul în care COVID-19 afectează femeile însărcinate și nou-născuții precum și impactul pe termen lung a infecției SARS-CoV2 asupra femeilor ce au născut, indiferent de statusul imunologic la momentul nașterii.
Nocebo & placebo – o abordare etică | [Nocebo & placebo – an ethical approach]
Authors: Nicolau Andrada , Rogozea Liliana
Published: March 2024

Introduction: Placebo & Nocebo are two aspects of medical practice less known and evaluated, although the ethical implications are complex and should be a subject of systematic analysis and even systematic research both from the point of view of medical staff, regardless of his training, of people involved in medical ethics. The purpose of the study was to analyse the general ethical aspects of the placebo and nocebo phenomena, and then the practical implications of the use of the two approaches were addressed. Material and method: Articles published in databases, such as Google Scholar, PUBMED, ISI, were analyzed. Results: The placebo effect was considered a gold standard, to which research for the introduction of a new treatment was reported, but later ethical analysis showed that the use of placebo raised a number of problems related to non-treatment. With the nuance of the analyzes, the introduction of psychological, behavioral type analysis appeared the description and analysis of the nocebo phenomenon, sometimes correlated with adverse events, negative manifestations. Conclusions: From an ethical point of view there will always be an attempt to answer the question: What is the ratio of the benefit of describing all the possible complications of a treatment and their minimization in order to be able to avoid the appearance of the nocebo phenomenon.
Rezumat:
Introducere: Placebo & Nocebo sunt două aspecte ale practicii medicale mai puțin cunoscute și evaluate, deși implicațiile etice sunt complexe și ar trebui să fie un subiect de analiză și chiar de cercetare sistematică atât din punct de vedere al personalului medical, indiferent de pregătirea lui, de persoanele implicate în etica medicală. Scopul studiului a fost să analizeze aspectele generale etice ale fenomenelor placebo și nocebo, urmând ca ulterior să fie abordate implicațiile practice ale utilizării celor două modalități de abordare. Material și metodă: Au fost analizate articole publicate în baze de date, precum Google Scholar, PUBMED, Clarivate - Web of Science. Rezultate: Efectul placebo a fost considerat un standard de aur, la care se raportau cercetările pentru introducerea unui nou tratament, dar ulterior analiza etică a demonstrat că folosirea placebo ridică o serie de probleme legate de non-tratament. Odată cu nuanțarea analizelor, introducerea analizei de tip psihologic, comportamental a apărut descrierea și analiza fenomenului nocebo, corelat uneori cu evenimentele adverse, manifestări negative. Concluzii: Din punct de vedere etic va exista în permanență încercarea de a răspunde la întrebarea: Care este raportul dintre beneficiul de a descrie toate complicațiile posibile ale unui tratament și minimalizarea acestora pentru a putea evita apariția fenomenului nocebo.
Filme subțiri pentru îmbunătățirea proprietăților implanturilor de titan | [Thin films for improving the properties of titaniumim plants]
Authors: Floroian Laura
Published: March 2024

Introduction: Biomaterials are currently widely used in the human body for various prostheses and orthopedic devices, and they must exhibit negligible dissolution rates in the body and have appropriate mechanical properties for specific uses. The main objective of the study: Realization of coatings of titanium implants, with the help of advanced laser methods, which will increase their life span, prevent metal delamination, the penetration of metal ions into the body and the production of inflammatory effects. Results and discussion: TiN thin films were deposited on Ti substrates, then evaluated from the structural, mechanical and electrochemical properties point of view. Conclusions: Coating titanium implants with TiN thin films is a good method to increase the corrosion resistance and mechanical strength of Ti implants. The presence of films on the surface of Ti considerably diminishes the corrosion of the implants and the release of metal ions in the solution.
Rezumat
Introducere: Biomaterialele sunt în prezent utilizate pe scară largă în corpul uman pentru diverse proteze și dispozitive ortopedice și ele trebuie să prezinte viteze de dizolvare neglijabile în organism și să aibă proprietăți mecanice adecvate pentru utilizări specifice. Obiectivul principal al studiului: Realizarea de acoperiri ale implanturilor de titan, cu ajutorul metodelor laser avansate, care să mărească durata lor de viață, să împiedice delaminarea metalului, pătrunderea ionilor metalici în organism și producerea de efecte inflamatorii. Rezultate și discuții: Pe substraturi de Ti au fost depuse filme subțiri de TiN, evaluate apoi din punct de vedere structural, al proprietăților mecanice și electrochimice. Concluzii: Acoperirea implanturilor de titan cu filme subțiri de TiN este o metodă bună de creștere a rezistenței la coroziune și a rezistenței mecanice a implanturilor de Ti. Prezența filmelor pe suprafața de Ti diminuează considerabil coroziunea implanturilor și eliberarea ionilor metalici în soluție.
ON THE ASYMPTOTICS OF EIGENVALUES OF THE NEUMANN PROBLEM FOR THE SCHRODINGER ¨ OPERATOR
Authors:   Azerbaijan State Oil and Industry University, Baku, Azerbaijan, Aliev Araz
Published: March 2024

. In this paper, we study the change in the eigenvalues of the Neumann problem for the Schr¨odinger equation with respect to the radius of the ball. We prove the self-adjointness of the Schr¨odinger operator with a spherically symmetric homogeneous potential and obtain asymptotic formulas for the eigenvalues of the Neumann problem as the radius of the ball tends to zero.
Upper bounds for Berezin numbers of self-adjoint operators and applications
Authors:   College of Science, King Saud University, Riyadh, Saudi Arabia, Garayev Mubariz , Guediri Hocine , S.N. Alshormani Farouq
Published: March 2024

We prove upper bounds for Berezin symbols and Berezin numbers of operators, with a special emphasis on the quadratic weighted operator geometric mean. In particular, we prove some upper bounds for Berezin symbols and Berezin numbers of some self-adjoint operators on reproducing kernel Hilbert spaces over some suitable sets. Moreover, we estimate the best possible constant in some generalized Hardy-Hilbert inequality for the series.
THE REGULARIZED TRACE FORMULA FOR A DISCONTINUOUS STURM-LIOUVILLE PROBLEM WITH A SPECTRAL PARAMETER DEPENDENT JUMP CONDITION
Authors:   Khazar University, Baku, Azerbaijan, N. Atamova Lala , A. Huseynli Ali
Published: March 2024

The first regularized trace formula for a discontinuous Sturm-Liouville problem with a spectral parameter dependent jump condition is obtained.
ON THE MINIMALITY OF A PART OF EIGEN- AND ASSOCIATED VECTORS FOR A CLASS OF THIRD-ORDER QUASI-ELLIPTIC OPE
Authors:   Azerbaijan State Oil and Industry University (ASOIU), T. Gazilova Aydan , S. Mirzoev Sabir ,   Baku State University
Published: March 2024

In the paper, we derive sufficient conditions on the coefficients of a thirdorder quasi-elliptic operator pencil, ensuring the minimality of its system of eigen- and associated vectors corresponding to eigenvalues from the left half-plane. Additionally, we prove a theorem on the minimality of decreasing elementary solutions to a homogeneous equation in a Sobolev-type space.
Money Supply, Banking and Economic Growth: A Cross Country Analysis
Authors: AlHarbi Ahmad , Sbeiti Wafa , Ahmad Moid
Published: March 2024

The primary objective of the research is to understand the interactions between money supply, banking and economic growth for effective policy interventions and business decisions. Based on annual data for the time period (2004-2021), descriptive analysis, correlations, causality tests and panel data regressions are analyzed for a sample from India, Saudi Arabia and UAE to draw conclusions. The results favored the ‘intermediation theory’ and were contrary to the ‘credit creation’ theory of banking. It was observed that the GDP of a country can be efficiently explained by financial soundness, broad money, loans and deposits for a country. Also, that the GDP of a country influences banking loans and deposits but not vice versa. The monetary policy of the sample was questioned by the finding that GDP causes banking loans and banking deposits but not vice versa. This important finding will add to the effectiveness in business decision making.
Influence of mineral nutrition and predecessors on the yield and quality of soybean seed in the crop rotation link
Authors: Svirina V. A. , Chernogaev V. G.
Published: March 2024

Studies conducted in the Ryazan region have shown that both the presence of mineral nutrition and the nature of the predecessors in the crop rotation are extremely important for the soybean yield. The experiment was carried out on six-field crop rotations with two backgrounds of fertilizers — without fertilizers and with the application of (NPK)90. The soybean of the Georgiy variety, which is the fifth link in crop rotations, was used as an object of study. Barley, winter wheat, and various perennial grasses were present in each of the crop rotations. To replenish organic matter in the soil, the organic mass of plants in the form of crop residues after harvesting the main part of the crop and perennial grasses included in the crop rotation was crushed and incorporated into the soil. In each crop rotation at the time of soybean cultivation, soil fertility, yield and quality of soybean seed were studied in order to identify the best predecessors. It was revealed that the highest yield is achieved in a crop rotation with legume-grass grasses using (NPK)90 — the largest increase in relation to unfertilized options was 14%, 11% and 22.8%. Variants with fertilizers also demonstrate the best indicators of soybean seed quality in terms of protein and oil content, where crop rotations with legumes and grasses also reach the highest values. It was revealed that all fertilized variants with were characterized by better indicators of soil fertility compared to unfertilized ones. It is concluded that the presence of perennial sideral grasses has a positive effect on soil fertility and contributes to an increase in soybean yields.
The results of the variety testing of cannabis in the conditions of the Republic of Bashkortostan
Authors: Bikbaeva G. G. , Islamgulov D. R.
Published: March 2024

Relevance. In recent years, this crop, which is cultivated in order to obtain oil and fiber, is gradually gaining its abundance, increasing the acreage. In many agro-industrial enterprises, hemp is being introduced into crop rotations, and plants for its processing are being built. This culture plays a huge national economic importance and finds its application in various industries. One of the main elements of cannabis cultivation technology is the use of highly productive varieties.

Methodology. The laying of field experiments, related observations and records were carried out in accordance with existing methodological guidelines for conducting field and vegetation experiments with cannabis.

Results. The most optimal variety for the conditions of the Southern forest-steppe zone of the Republic of Bashkortostan is the Nadezhda variety. This variety is superior to the others (Vera and Omegadar-1) in terms of quality and quantity. For example, from the 2021–2022 studies on biomorphometric indicators, it follows that Nadezhda achieved the best indicators for: plant height (194.50 cm and 194.33 cm), technical stem length (160.60 cm and 162.45 cm), inflorescence length (33.90 cm and 31.88 cm), stem diameter (0.8–0.9 cm), the number of internodes (8–9 pcs.), the average length of internodes (12.5 cm and 19.87 cm). The weight of 1000 seeds was 17.01 g and 18.10 g, oil content — 32.89% and 33.72%, yield — 0.88 t/ha and 1.71 t/ha. The greatest results in 2022 are associated with agrometeorological conditions.
Trends in global sugar beet production and sugar consumption levels
Authors: Kuznetsova A. R. , Zholdoyakova G. E. , Akhmetyanova A. I. , Kuznetsov A. I.
Published: March 2024

Relevance. Sugar beet is one of the raw materials from which granulated sugar is produced, and it, in turn, is one of the indicators by which the food security of any country is assessed. In 2020, European countries produced 47.6% of the total global volume of sugar beet, Asian countries — 18.6%, America — 13.3%, the Russian Federation — 13.7%, African countries — 6.7%. At the same time, the share of sugar beet production in global production increased in Asian countries (from 15.9% in 2010 up to 18.6% in 2020), in the Russian Federation (from 10.1 to 13.7%), in African countries (from 4.6 to 6.7%). A decrease in sugar beet production was noted in European countries — from 55.4% in 2010 to 47.6% in 2020, in American countries — from 14 to 13.3%. In the Russian Federation, sugar production per capita generally meets not only rational consumption standards, but also all criteria for food self-sufficiency. The excess of actual consumption over rational consumption in Russia is 62.5%. The lowest sugar beet production volumes are observed in countries such as Greece, Portugal, North Macedonia, Pakistan, Azerbaijan, Turkmenistan, Kazakhstan, Moldova, Kyrgyzstan, and some others.

Results. The results of the study showed that in order to increase the economic indicators of sugar beet production, Russian commodity producers need to implement a policy of intensification of agricultural production along with updating the material and technical base using modern agricultural technologies and the development of their own breeding and genetic centers.
Microbial landscape in acute purulent-catarrhal postpartum endometritis in cows
Authors: Lutsay V. I. , Soloshenko N. Yu. , Nefedov A. M. , Sibirtsev V. D. , Rudenko A. A. , Rudenko P. A.
Published: March 2024

A special place among environmental factors affecting the body of animals is occupied by microorganisms— pathogens of infectious diseases. In this regard, the problem of circulation of associations of conditionally pathogenic microorganisms capable of causing a fairly wide range of pathologies in cattle in cattle is acute. The article provides a study of the microbial background of the vaginal-luminous contents selected in the acute purulent-catarrhal postpartum endomethry in cows. It was shown that 58 strains of opportunistic microorganisms of 13 species, classified into 6 genera, were isolated from 20 cows suffering from acute purulent catarrhal endometritis. The most frequently isolated cultures were St. aureus, E. coli (serotypes O4, O9 and O83), Str. pyogenes, Str. agalactiae, P. aeruginosa, Str. uberis and Str. faecalis. Moreover, the development of acute purulent-catarrhal endometritis in cows was more often caused by grampositive bacteria. Of the 58 isolated strains of microorganisms, 22 (37.9%) cultures caused the death of white mice when administered intraperitoneally. At the same time, gram-positive cocci were more likely to have pathogenic properties, namely representatives of the genera Streptococcus spp. (11 — 50.0%) and Staphylococcus spp. (6 — 27.3%) isolates, respectively. It was found that endometritis more often causes associations of opportunistic microorganisms, which included three joints in 14 (50.0%) cases, less often four joints in 7 (25.0%) cases. The isolated microorganisms were sensitive to only three antibacterial drugs: cefkin, cefepime and marbofloxacin.
Morphological changes in the liver of bulls after the use of adaptogens
Authors: Mironova I. V. , Khabibullin R. M. , Khabibullin I. M.
Published: March 2024

The paper presents the results of a study of the influence of adaptogens of plant and animal nature on the productive qualities of Kazakh white-headed bulls and morphological changes in their liver. 40 6-month-old beef bulls were selected for the study, which were divided into 4 groups: I (control) group of bulls consumed only the basic diet, II — adaptogen leucea safflower, III — drone homogenate, IV — pantocrine at the rate of 0.01 ml per 1 kg of animal body weight. At 18 months, a control slaughter of 3 animals from each group was carried out. During the experiment, it was found that the mass of the paired carcass in the bulls of the experimental groups increased by 11.1–21.7 kg (4.25–8.31%, р ≤ 0.05), the slaughter weight by 11.7–23.0 kg (4.24–8.34%, р ≤ 0.05–0.01), the slaughter yield by 0.9–1.9%. The analysis of the morphological composition of the carcass indicates an increase in the specific weight of its edible part of the carcass: by weight of muscle tissue by 4.0–7.7 kg (4.66–8.97%, р ≤ 0.05–0.01), fat — by 0.7–1.4 kg (4.67–9.33%, р ≤ 0.05). There is a high degree of maturity and high nutritional value of the meat of bulls of the experimental groups. Histological studies of the liver of bull calves indicate that when using tincture from drones, the liver structure corresponds to the norm, while in the control group animals some signs of dystrophic changes without pronounced infiltrations and signs of stagnation were found.
The effect of Bacillus in the composition of the probiotic Natupro® against bacterial pathogenic strains in vitro
Authors: Ilyashenko A. N.
Published: March 2024

Relevance. The use of probiotics for health benefits is becoming popular because of the quest for safer products with protective and therapeutic effects against diseases and infectious agents. The emergence and spread of antimicrobial resistance among pathogens had prompted restrictions over the nontherapeutic use of antibiotics for prophylaxis and growth promotion, especially in animal husbandry. While single-strain probiotics are beneficial to health, multi-strain probiotics might be more helpful because of synergy and additive effects among the individual isolates.

Methods. In this study, the effectiveness of the multi-strain probiotic Natupro on pathogenic bacterial strains (Escherichia coli 320, Salmonella typhimurium 415, Staphylococcus aureus 12600, Streptococcus uberis 700407, Klebsiella pneumoniae 13883, Listeria monocitogenes 766/20) in vitro was studied.

Results. According to the results of the work carried out, it was found that the bacterial strains in Natupro® exhibit lytic activity against pathogenic strains of Salmonella typhimurium 415 and Klebsiella pneumoniae 13883 and have a bacteriostatic effect on Escherichia coli strain 320 and Salmonella typhimurium 415.
Influence of genotype of lam on the consumption and use of nutrients in the diets
Authors: Kosilov V. I. , Yuldashbaev Yu. A. , Nikonova E. A. , Rakhimzhanova I. A. , Kalyakina R. G. , Dolgaya M. N.
Published: March 2024

Relevance. The results of a study of the consumption and use of dietary nutrients by purebred and crossbred rams are presented.

Methodology. To conduct the study, experimental groups of rams were formed from newborn young animals: I— Romanovskaya breed, II— 1/2Romanovskaya × 1/2edilbai, III— × 1/4Romanovskaya × 3/4edilbai. To study the consumption and use of nutrients in the diet, a balance experiment was carried out using the VIZh method (A.I. Ovsyannikov, 1976).

Results. It has been established that crossbred young animals consume and use the nutrients of the diet most intensively. It is enough to note that the coefficient of digestibility of nutrients by young animals of the experimental group III was higher than by young animals of groups I and II, on average by 0.3–1.75. The results obtained indicate that crossbred young animals of groups II and III made better use of dietary nutrients than purebred peers. At the same time, crossbred young animals of group III were characterized by a better ability to digest nutrients in diets.
Inibidores BTK e BCL-2 no Tratamento de Primeira Linha da Leucemia Linfocítica Crônica em Pacientes de Alto Risco: Revisão Sistemática e Meta-Análise em Rede
Authors: Albuquerque Rita de Cássia Ribeiro de , Vieira Cláudia Lima , Santiago Isabel Cristina de Almeida , Nascimento Aline do , Chança Raphael Duarte , Tura Bernardo Rangel , Correia Marcelo Goulart , Barufaldi Laura Augusta
Published: March 2024

Introdução: Pacientes com leucemia linfocítica crônica (LLC) com alto risco têm menores taxas de resposta, curso clínico mais agressivo e resistência à quimioterapia padrão, representando um desafio para o tratamento. Os inibidores da tirosina quinase de Bruton (BTK – ibrutinibe e acalabrutinibe) e o inibidor BCL-2 (venetoclax) podem ser utilizados nesses casos. Objetivo: Identificar e avaliar a eficácia e a segurança do uso de ibrutinibe, acalabrutinibe e venetoclax no tratamento de primeira linha em pacientes com LLC de alto risco. Método: Revisão sistemática de ensaios clínicos randomizados que avaliaram pacientes adultos com LLC, portadores de deleção 17p ou mutação TP53 e sem tratamento prévio. Foram pesquisadas as bases PubMed, EMBASE, LILACS e Cochrane Library, e realizadas avaliação do risco de viés pela ferramenta RoB 2 da Cochrane e avaliação da qualidade da evidência pelo GRADE. Resultados: Na meta-análise em rede para sobrevida livre de progressão (SLP), venetoclax + obinutuzumabe (RR: 0,62; IC 95% 0,41-0,95; p = 0,027) e acalabrutinibe + obinutuzumabe (RR: 0,74; IC 95% 0,55-0,99; p = 0,043) apresentaram menor risco de progressão ou óbito, com significância considerada limítrofe. Ibrutinibe + obinutuzumabe (RR: 0,93; IC 95% 0,86-1,00; p = 0,054) não apresentou diferença significativa na SLP para pacientes com LLC de alto risco. Conclusão: O tratamento de primeira linha com inibidores de BTK (ibrutinibe e acalabrutinibe) e o inibidor BCL-2 (venetoclax), associados a agentes monoclonais anti-CD20 – especialmente o obinutuzumabe –, tem sido proposto como padrão para a maioria dos pacientes com LLC. Entretanto, pelos resultados desta revisão com meta-análise em rede, não foi possível confirmar essa recomendação.
ОЦІНКА ТА ПЕРСПЕКТИВИ ВИРОБНИЧОГО ПОТЕНЦІАЛУ СІЛЬСЬКОГОСПОДАРСЬКИХ ПІДПРИЄМСТВ В УМОВАХ ВІЙНИ
Authors: Журбенко Наталія
Published: March 2024

В статті досліджуються аспекти оцінки та перспектив виробничого потенціалу сільськогосподарських підприємств в умовах війни в Україні. В процесі дослідження встановлено актуальність досліджень виробничого потенціалу сільськогосподарських підприємств в умовах війни, а також необхідність подальших досліджень. Визначено вплив військових дій на стан виробничого потенціалу та ефективності використання наявних виробничих ресурсів підприємницькими структурами в галузі сільськогосподарського товаровиробництва, особливо в прифронтових областях України. Досліджено динаміку виробництва та площ сільськогосподарських угідь, зайнятих під виробництвом окремих культур за 2021-2022 роки, зроблено відповідні висновки. Досліджено зміну середньої врожайності окремих сільськогосподарських культур у прифронтових областях за 2021-2022 роки, зроблено відповідні висновки. Досліджено частки збитків та втрат за їх типами в сільськогосподарських підприємствах України (в млн дол. США) за період 2021-2022 р., зроблено відповідні висновки. Визначено прогнозні показники загальних збитків, спричинених військовими діями рф проти України, станом на 2023 рік в галузях рослинництва і тваринництва. Досліджено ефективність використання виробничих ресурсів та активів в галузі рослинництва та тваринництва, зроблено відповідні висновки. Сформовано узагальнені висновки щодо поточного організаційно-економічного стану господарюючих суб’єктів в галузі рослинництва та тваринництва.
РОЛЬ ПРОЦЕСІВ АПОПТОЗУ ТА ІМУННОЇ ВІДПОВІДІ У ПАТОГЕНЕЗІ ЗАХВОРЮВАНЬ ТКАНИН ПАРОДОНТА (ОГЛЯД ПРОБЛЕМНИХ ПИТАНЬ)
Authors: Мартовлос О.І. , Чухрай Н.Л. , Пупін Т.І. , Шибінський В.Я. , Годований О.В.
Published: March 2024

Мета – аналіз результатів досліджень різних років та формулювання на його основі орієнтовного уявлення про деякі аспекти апоптичних та імунних процесів як окремих ланок складного і багатогранного патогенезу хронічного генералізованого пародонтиту. Матеріали і методи дослідження. Методологія даного дослідження базувалась на пошуку та аналізі наукових результатів щодо окреслених проблемних питань апоптичних та імунних процесів у патогенезі хронічного генералізованого пародонтиту, що є опублікованими у виданнях, представлених у доказових базах даних MEDLINE/PubMed, PMC, Scopus, Web of Science, Cochrane, Google Scholar, ResearchGate та інших науково-практичних ресурсів. Наукова новизна: Проаналізовано наукові дані щодо впливу складних апоптозних механізмів, які керують загибеллю клітин, та роботи імунної системи на розвиток і прогресування хронічного генералізованого пародонтиту. Висновки. 1. Встановлено, що апоптоз, або запрограмована загибель клітин, може бути одним із важливих механізмів, що є в основі патофізіології прогресування захворювань тканин пародонта. 2. Під час перебігу патологічного процесу наявність патоген-асоційованих молекулярних структур викликає специфічні антимікробні імунні відповіді для контролю над інфекцією. За певних обставин клітини можуть регулювати свою загибель (апоптоз), щоб пристосувати імунну відповідь, таким чином змінюючи вплив, який їх втрата матиме на оточення. Завершальним кроком сигнального шляху, що веде до апоптозу, є активація деяких протеаз, включно із каспазами та ендонуклеазами. Під час апоптозу клітини активація каспази може бути функціонально залучена до ушкодження тканин, пов’язаного із хронічним генералізованим пародонтитом. 3. Домінування клітин Тh1 (Т-хелперів 1) призводить до агресивного перебігу патологічного процесу, значної резорбції кістки і зменшення остеогенезу внаслідок підвищеної продукції інтерлейкінів – IL-1 та IL-2. Водночас фаза Тh2, що супроводжується підвищеною секрецією В-клітин – стимуляторів інтерлейкінів, виконує захисну функцію. 4. Під час запалення тканин пародонта активація окремих підтипів Т- і В-клітин, а також продукція ними цитокінів є вирішальними факторами у тому, чи буде патологічний процес розвиватися як зворотній у вигляді гінгівіту чи прогресуватиме як генералізований пародонтит із формуванням глибоких пародонтальних кишень та вертикальних кісткових дефектів.
The effect of complex treatment including osteopathic correction on pain intensity and quality of life in patients with chronic tonsillitis
Authors: Vedyashkina A. S. , Mokhov D. E. , Bezrukova E. V. , Artyushkin S. A.
Published: March 2024

Introduction. The relevance of the problem of chronic tonsillitis is due to the wide spread of the disease and the occurrence of complications associated with it, which, in turn, contributes to the appearance of pain and a decrease in the quality of life. Available information about the role of the palatine tonsils as an important organ of the immune system makes conservative treatment methods more preferable. Conventional conservative treatment is reduced to episodic implementation of individual techniques and remains insufficiently effective. Obtaining in-depth knowledge about the mechanisms of development of chronic tonsillitis necessitates the search for an integrated approach to treatment including non-drug methods. Often, questions about the severity of pain in patients that affect the level of quality of life are not given due attention.

The aim is to study the effect of complex treatment including osteopathic correction on the quality of life and intensity of pain in patients with chronic tonsillitis.

Materials and methods. In a prospective controlled randomized study conducted at the Department of Osteopathy and the Department of Otorhinolaryngology of the North-Western State Medical University named after I. I. Mechnikov of the Ministry of Health of Russia in the period from 06.2022 to 06.2023, 60 patients with a diagnosis of chronic tonsillitis were included. All patients, depending on the treatment, were divided using the randomization envelope method into two groups — main (n=30) and control (n=30). Patients in both groupsreceived otorhinolaryngological treatment in the form of lavage of the palatine tonsils (five rinsing procedures using an antiseptic solution, the interval between procedures was 2 days). Patients in the main group additionally received osteopathic correction (three procedures with an interval of 14 days). In all patients, before and after completion of treatment, the intensity of pain was assessed using a visual analogue scale (VAS) and quality of life using the SF-36 questionnaire.

Results. In patients of both the main and control groups, there was a statistically significant decrease in the intensity of sore throat (p<0,05) after treatment. The increase in the level of quality of life in terms of both physical and psychological components of health was statistically significant (p<0,001) in patients of the main group. The level of quality of life in patients in the control group increased only due to the psychological component (p<0,001) of health, and the indicators of the physical component did not change (p=0,092).

Conclusion. The inclusion of osteopathic correction in the complex therapy of patients with chronic tonsillitis in the inter-relapse period helps to reduce the pain and improve the physical component of quality of life compared to traditional conservative treatment alone. The study should be continued with a larger sample.
Change in the functional activity of fibroblasts in patients with coronavirus infection (history of SARS-CoV-2)
Authors: Aptekar I. A. , Kostolomova E. G. , Sukhovey Yu. G. , Aptekar V. I. , Abramova E. V.
Published: March 2024

Introduction. In the genesis of the formation of somatic dysfunction, the leading role is given to adaptive reactions on the part of the body as a whole and connective tissue in particular. The main cells of connective tissue are fibroblasts, which have an important role in the formation of the structural and functional characteristics of connective tissue. There is an opinion that after a coronavirus infection, the adaptive activity of fibroblasts changes in response to external influences.

The aim is to study changes in the functional activity of fibroblasts during a simulated compression effect on a culture of fibroblasts obtained from patients who suffered coronavirus infection 3–6 months before the experiment.

Materials and methods. Under experimental conditions (in vitro), compression conditions were simulated in relation to a culture of fibroblasts taken from patients who had suffered a coronavirus infection (with a history of SARS-CoV-2) and patients who had no history of coronavirus infection.

Results. Under experimental conditions, it was found that fibroblasts from patients who have suffered coronavirus infection have altered functional activity, manifested by a decrease in secreted glycosaminoglycans, elastin and collagen in response to in vitro modeling of the compression factor.

Conclusion. The established response of fibroblasts to compression allows us to justify the need for priority elimination of this factor as part of osteopathic correction in patients who have suffered coronavirus infection during treatment and rehabilitation.
Paisaje Hídrico y Ciclos Hidrosociales Ichsma e Inca en el Valle Bajo Del Rímac Del 900/1000 D.C. Al 1532 D.C.
Authors: Chacaltana-Cortez Sofía , Ventura Gilda Cogorno
Published: March 2024

Desde la perspectiva de  la ecología política se analiza el paisaje hídrico durante la presencia Ichsma (900/1000 – circa 1450 d.C.) a la ocupación Inca (circa 1450 – 1532 d.C.) del valle bajo del Rímac de la costa central del Perú. Se utilizan metodologías como Sistema de Información Geográfica (SIG), fotos aéreas y mapas históricos para obtener un modelamiento del terreno con el objetivo de identificar los cursos y el crecimiento de los canales, las rutas de menor costo y calcular el área de irrigación en estos dos periodos. Estos datos permitieron identificar el paisaje hídrico formado por ciclos hidrosociales con el fin de vislumbrar el gobierno hídrico de los curacazgos Ichsma y la sucesiva ocupación incaica de la margen derecha del valle bajo del Rímac. Se observa que las dinámicas hídricas de estos canales dendríticos reflejan relaciones sociopolíticas heterárquicas complejas y que los ichsma tuvieron un manejo y gobierno del agua que permitió una amplia negociación entre curacazgos. Luego, bajo la ocupación del imperio Inca en el valle, se continuó con la misma tecnología hídrica, pero se gestó otros principios reguladores del agua que marcaron los ciclos hidrosociales que beneficiaban la gobernanza hídrica del imperio y de los curacazgos aliados.
Carl O. Sauer: Historia Intelectual, Paisajes Agrícolas y el Origen del Maíz, 1940-1960
Authors: Torres Pedro Urquijo , Méndez Rojas Diana Alejandra
Published: March 2024

Analizamos las aportaciones conceptuales para el estudio de los paisajes agrícolas planteadas por el geógrafo Carl O. Sauer, figura líder de la Escuela de Berkeley. Damos seguimiento a su defensa del maíz nativo en el contexto de emergencia de la Revolución Verde y el avance de los programas agrícolas auspiciados por la Fundación Rockefeller en América Latina. Sauer consideraba que la introducción de los paquetes agronómicos y de fitomejoramiento agrícola, con la consecuente estandarización bajo criterios comerciales estadounidenses, arruinarían la diversidad histórica de los cultivos. Basándose en su experiencia en territorio mexicano y el suroeste estadounidense, Sauer enfatizaba que el maíz y los paisajes agrícolas poseían una suerte de “personalidad local”, resultante de una correlación entre las condiciones geográficas específicas de cada sitio y de los tipos de manejos y adaptaciones brindados por las sociedades que ahí se establecían. Nos planteamos dos objetivos. Primero, reconocer los conceptos directrices del enfoque de la geografía cultural y del estudio histórico de paisajes, y cómo ellos conducen, intelectual e ideológicamente, al análisis del origen del maíz, su distribución geográfica y el significado identitario. Ponemos énfasis en las nociones de difusionismo, particularismo histórico, geografía cultural, personalidad de paisaje y estudios de área. Segundo, realizamos una aproximación a la historia relacional de Sauer, mediante el análisis del intercambio epistolar que el geógrafo tuvo con colegas respecto a su interés y defensa del maíz.
Empatía Preventiva Ecológica: Propuesta para la Articulación Ética en Tiempos del Antropoceno
Authors: Bámaca-López Efraín , De la Vega Pablo , Orcasitas Luis Jorge
Published: March 2024

El deplorable estado del medioambiente en esta segunda década del siglo XX invita a revalorizar los planteamientos y aproximaciones éticas realizadas sobre la relación del ser humano y su entorno. Con ello, se patentiza la necesidad de un principio de incidencia que articule la acción humana sobre el medioambiente: la empatía preventiva ecológica. El presente texto desarrolla esta propuesta a través de un recorrido reflexivo sobre las necesidades y características de esta nueva época geológica: el Antropoceno, donde el ser humano se posiciona como una fuerza de impacto para su entorno. Aquí se analiza cómo los planteamientos éticos han fallado al presentar una disyunción normativa, generalizando propuestas que en casos singulares no son aplicados, y denotando la urgencia ética de nuevas soluciones. Los avances reflexivos de los últimos años y las nuevas aproximaciones teóricas de la relación del ser humano con el medioambiente han presentado una novedosa filosofía medioambiental, con postulados como la Deep Ecology y la Ecosofía. Con base en estas nuevas ideas se construye la propuesta de empatía preventiva ecológica. Aquí se abordarán las distintas significaciones de los elementos que constituyen esta idea, su ámbito de aplicación e importancia moral. Se concluye argumentado que esta nueva propuesta constituye una superación de las problematizaciones de la disyunción normativa y un camino para lograr una eficiente ética ecológica.
Historia Ambiental con Perspectiva Relacional: La Territorialización de la Cuenca del Río Chepu, Chiloé, Chile 1982-2022
Authors: Vivanco Pablo Aguilera , Wells Gustavo Blanco
Published: March 2024

El presente artículo expone los resultados de una investigación acerca de la historia ambiental de una cuenca hidrográfica en el sur de Chile. Mediante un trabajo historiográfico y etnográfico se reconstruyó el proceso de territorialización de la cuenca analizando procesos de colonización agroforestal, conservacionismo e irrupción de prácticas extractivo-empresariales. Los resultados muestran que aspectos de la nueva ruralidad latinoamericana se territorializan mediante la continuidad, divergencia y conflicto en las relaciones establecidas históricamente en el territorio. Las cuales se ven influenciadas por agentes que, interna y externamente, empujan dichos procesos. El estudio concluye que el proceso de territorialización abordado permite visibilizar la relevancia de las relaciones entre agentes humanos y no humanos en el territorio, valorar las relaciones que posibilitan agentes animales y vegetales, y aportar a la construcción de un relato histórico no lineal que visibilice la complejidad de los procesos de carácter ambiental.
Edukasi Remaja dalam Meningkatkan Pengetahuan tentang Kesehatan Mental di SMAN 8 MAROS
Authors: Darlis Idhar , T.A Tenri Diah , Putri Adhinda , Kas Sri Reskiani , Yanti Putri , Ampang Allo Asna , Mustakim Musyahidah
Published: March 2024

Adolescence is especially important for improving mental health because more than 50% of mental health problems begin at that time and many of them persist into adulthood. The increasing cases of adolescent mental disorders indicate a lack of effective mental health care for adolescents. This is clearly an important issue that has an impact on the mental development of teenagers. Addressing adolescent mental health is by increasing knowledge about the problem. The focus of this activity is to increase teenagers' knowledge about mental health and its impacts. The methods used in this activity are lectures and discussions. With a total of 60 teenagers participating, the education was carried out at SMAN 8 Maros. The results obtained after the education was carried out were an increase in the level of knowledge of teenagers regarding mental health and its impacts and how to deal with it. Advice to teenagers is expected to disseminate the information that has been obtained to other teenagers.
Asuhan Kebidanan Bayi Baru Lahir pada Bayi Ny. L
Authors: Pratama Wara-wara Jihan , Saputri Linda Hardianti , Thamrin Halida
Published: March 2024

Angka kematian bayi adalah jumlah kematian bayi dalam usia 28 hari pertama kehidupan per 1000 kelahiran hidup menurut WHO pada tahun 2013 di dunia sebanyak 34 per 1.000 kelahiran hidup, di negara berkembang sebanyak 37 per 1.000 kelahiran hidup dan di negara maju sebanyak 5 per 1.000 kelahiran hidup, ini menunjukan bahwa angka kematian bayi di negara berkembang lebih tinggi. Menurut Survei Demografi dan Kesehatan Indonesia tahun 2017 menunjukkan angka kematian bayi 24 per 1.000 kelahiran hidup, dan angka kematian balita 32 per 1.000 kelahiran hidup. Meskipun demikian angka kematian bayi dan balita diharapkan akan terus mengalami penurunan, intervensi-intervensi yang dapat mendukung kelangsungan hidup anak ditujukan untuk dapat menurunkan angka kematian bayi menjadi 16 per 1000 kelahiran hidup di tahun 2024. Sementara itu, sesuai dengan target pembangunan berkelanjutan, angka kematian balita diharapkan dapat mencapai angka 18,8 per 1.000 kelahiran hidup di tahun 2030. Tujuan dilakukannya studi kasus ini adalah untuk memberikan asuhan kebidanan pada kasus bayi baru lahir pada Bayi Ny. L dengan lahir cukup bulan di Klinik Pratama BKIA Rakyat, penyusunan studi kasus ini didasarkan pada teori ilmiah yang menggabungkan praktek dan pengalaman, penulis membutuhkan data subjektif dan objektif terkait teori yang digunakan sebagai dasar analisis pemecahan masalah, untuk itu penulis menggunakan metode anamnesis, pemeriksaan fisik, studi kasus, studi kepustakaan dan dokumentasi. Berdasarkan hasil penelitian ditemukan bahwa kasus yang terjadi pada Bayi Ny. L merupakan hal yang fisiologis, kesimpulan yang dapat penulis tarik yakni Bayi Ny. L dengan lahir cukup bulan tidak terdapat kesenjangan antara teori dan tinjauan kasus.
Mathematical Modeling of a Corrugated Geogrid and Geocell Reinforced Flexible Pavement Base with Interlayer Shear Performance Analysis
Authors: Kumar Santosh , Suman Sanjeev Kumar
Published: March 2024

To combat permanent deformation in flexible road pavements and extend lifespan while reducing maintenance costs, an investigated solution "Corrugated Geogrid and Geocell Reinforced Flexible Pavement Base Design" is proposed. It enhances durability by improving inter-layer bonding and increasing the friction coefficient with a Corrugated Imminent Hexagonal Composite Geogrid, boosting pavement bearing capacity. The necessity of this research is the integration of corrugated geogrids and geocells into the design of flexible pavement, in conjunction with a comprehensive evaluation of interlayer shear performance, effectively tackles a range of engineering obstacles and enhances the pavement system's durability, stability, and affordability. Geogrid's corrugated structure resists shoving, offers stabilization, and, combined with Fusion Geoblanket and Perforated Geocell, prevents potholes. Typically, geocellular brace parts are utilized in civil engineering and technical applications, and they are frequently connected to geocellular systems or geocells. These systems are frequently employed in the building of retaining walls, slope protection, erosion control, and soil stabilization. The intended use and product design influence the installation procedures and specific functioning approach. The proposed model prevents permanent pavement failures, ensuring durability, low maintenance, and improved lifespan, assessed through Finite Element Analysis. Thus, the proposed method develops a layout for flexible pavement that's going to prolong its life expectancy and prevent long-term deformation failure.
ПІСЛЯВОЄННИЙ СІЛЬСЬКИЙ ПРОСТІР ЗАКАРПАТТЯ: КОНФІСКАЦІЯ І РОЗПОДІЛ МАЙНА ВЦІЛІЛИХ У ГОЛОКОСТІ ЄВРЕЇВ, 1944–1945 РОКИ
Authors: Худіш Павло
Published: March 2024

У статті проаналізовано процес та механізми конфіскації майна вцілілих у Голокості євреїв у післявоєнному Закарпатті в 1944–1945 рр. Після вступу Червоної армії та вигнання угорської влади в регіоні була створена система тимчасових органів влади – народних комітетів. Ці органи влади на низових рівнях у сільських місцевостях складалися з неєвреїв, переважно українців, які були колишніми сусідами євреїв. У статті проаналізовано роль цих низових органів влади у процесі перерозподілумайна євреїв. Уцілілі,  які поверталися в села наприкінці 1944 р., не мали можливості вплинути на долю свого майна, оскільки не були включені до складу органів влади. Також описано роль вищих керівних органів квазідержавного утворення Закарпатська Україна в санкціонуванні розподілу нерухомості євреїв. Окремо ми звернули увагу на явище розграбування майна євреїв у перші місяці після вступу Червоної армії. Автор фокусується на реакціях місцевої влади різних рівнів щодо стихійного розграбування неєвреями єврейської власності.У статті розкрито питання створення спеціальних комісій, які займалися оцінкою майна євреїв. Окрім того, проаналізовано різноманітні сценарії перерозподілу єврейської власності. Зокрема, видача в оренду неєвреям будинків євреїв, продаж майна з аукціону, а також продаж нерухомості чи безкоштовна передача майна від вцілілого єврея до його колишнього сусіда. Аукціони з продажу будинків та інших приватних споруд євреїв стали поширеним явищем у сільській місцевості повоєнного Закарпаття. Окремо акцентується на бенефіціарах процесу перерозподілу єврейського майна та використанні коштів від продажу єврейських будинків. У першу чергу домівки євреїв отримували нові привілейовані верстви післявоєнного соціуму Закарпаття: добровольці Червоної та Чехословацької армій та їх сім’ї, а також інваліди війни. Водночас цей процес не мав чітко визначеного механізму й часто був пов’язаний із корупційними схемами. Питання єврейської власності призвело влітку 1945 р. до численних конфліктів як між вцілілими та неєвреями, так і між українцями. Це спричинило виїзд значної частини євреїв із соціально тісного сільського простору до міст, а також еміграцію за кордон.
COVID-19 Australia: Epidemiology Report 81 Reporting period ending 19 November 2023
Authors:   Viral Respiratory Diseases Epidemiology and Surveillance Section
Published: March 2024

This is the eighty-first epidemiological report for coronavirus disease 2019 (COVID-19), reported in Australia as at 23:59 Australian Eastern Daylight Time [AEST] 19 November 2023. It includes data on COVID-19 cases diagnosed in Australia.
Catálodo de madera estructural Ecuador
Authors:   Universidad del Azuay, Espinoza Pedro , Proaño Diego ,   Universidad del Azuay, Barrera Luis ,   Universidad del Azuay, Arpi Eva ,   Universidad del Azuay
Published: March 2024

Lejos de perder vigencia, el proceso evolutivo de la madera continúa en auge. Más aún con las nuevas patentes y tecnologías de prefabricación, con tratamientos físico-químicos de preservación y protección al clima o a agentes externos. Dentro de las propiedades estructurales, también existe un avance vertiginoso en las prestaciones que el material ofrece debido a que se han desarrollado interesantes sistemas de uniones, acoplamientos, ensambles, pegantes especiales, etc., que han permitido –entre otras cosas– desarrollar estructuras de grandes luces con formas increíblemente complejas (tecnología de madera laminada estructural MLE) con una altísima resistencia al fuego e inclusive, ya se está soñando en producir los primeros rascacielos con estructuras de madera. Esta investigación invita a repensar la madera como un material estructural contemporáneo. Y por esa misma razón, a redescubrir la belleza expresiva de la arquitectura a través del manejo correcto del material. 59 Páginas ISBN 978-9942-778-28-4