bluuebunny/crossref_metadata_2025 huggingface dataset:
Membrane Engineering for Carotenoid Production in Escherichia coli
Authors: Li Jiaqing , Bates Eileen , Perera Dylan S. , Palage Andreea M. , Ward Valerie C. A.
Published: October 2024

Carotenoids are a class of highly hydrophobic compounds synthesized by plants in limited quantities. This study explores the potential for increasing the production yield of lycopene, a typical carotenoid compound, through engineered Escherichia coli. Given that lycopene biosynthesis occurs within microbial hosts and it is subsequently stored within lipid membranes, this study focuses on the impact of inducing membrane vesicles on lycopene yield by expressing monoglycosyldiacylglycerol synthase (MGS) or diglucosyldiacylglycerol synthase (DGS) from Acholeplasma laidlawii and inserting the upstream isopentenol utilization pathway (IUP) into the chromosome. The effect of MGS and DGS on lipid production in the cell was quantified. The results show that inserting the IUP into the chromosome increased the specific lycopene yield by 2.1-fold compared to the plasmid-based system when using a PproD constitutive promoter and by 2.0-fold when using the inducible Ptrc promoter. The expression of MGS and DGS resulted in a small increase of 31% and 33% (w/w) lipid content, respectively. When expressed in lycopene producing strains, the lycopene content decreased in the IUP strains but increased in the negative control strain expressing only the native MEP pathway from undetectable levels to 0.34 ± 0.08 mg/g.
A Holistic Quality Improvement Model for Food Services: Integrating Fuzzy Kano and PROMETHEE II
Authors: Becerra Claudia Editt Tornero , Melo Fagner José Coutinho de , Xavier Larissa de Arruda , Albuquerque André Philippi Gonzaga de , Barbosa Aline Amaral Leal , Oliveira Lucas Ambrósio Bezerra de , Carvalho Raíssa Souto Maior Corrêa de , Medeiros Denise Dumke de
Published: October 2024

Service quality is crucial to consumer loyalty. However, it is challenging to understand and meet customer expectations effectively. Translating customer feedback into actionable insights in the service industry poses difficulties, particularly without a systematic approach that balances customer requirements with business constraints and strategic objectives. This study proposes an approach that integrates customer perspectives into multi-criteria decision models by utilizing the fuzzy Kano model to capture service perceptions and minimize response uncertainty. It also uses 5W2H and PROMETHEE II to formulate service improvement actions and establish prioritizations, providing a structured framework for managerial implementation. When implemented in the food truck sector, this framework proves effective in addressing unique challenges, enhancing service quality, boosting customer satisfaction, and fostering loyalty. This study offers a valuable contribution to management by presenting a replicable model that aids managers in making strategic decisions, aligning customer perspectives with management efforts, and providing insights for continuously improving initiatives within the food service industry.
Experimental Performance Comparison of Proactive Routing Protocols in Wireless Mesh Network Using Raspberry Pi 4
Authors: Turlykozhayeva Dana , Temesheva Symbat , Ussipov Nurzhan , Bolysbay Aslan , Akhmetali Almat , Akhtanov Sayat , Tang Xiao
Published: October 2024

Nowadays, Wireless Mesh Networks (WMNs) are widely deployed in communication areas due to their ease of implementation, dynamic self-organization, and cost-effectiveness. The design of routing protocols is critical for ensuring the performance and reliability of WMNs. Although there have been numerous experimental works on WMNs in the past decade, only a few of them have been tested in real-world scenarios. This article presents a comparative analysis of three proactive routing protocols, OLSR, BATMAN, and Babel, using Raspberry Pi 4 devices. The evaluation, conducted at Al-Farabi Kazakh National University, covers both indoor and outdoor scenarios, focusing on key metrics such as bandwidth, Packet Delivery Ratio (PDR), and jitter. In outdoor scenarios, OLSR achieved the highest bandwidth at 2.9 Mbps, while BATMAN and Babel lagged. Indoor tests revealed that Babel initially outperformed with the highest bandwidth of 57.19 Mb/s but suffered from scalability issues, while BATMAN and OLSR exhibited significant declines in performance as network size increased. For PDR, BATMAN performed best with a decline from 100% to 42.8%, followed by OLSR with a moderate drop, and Babel with the greatest decrease. For jitter, OLSR showed the most stable performance, increasing from 0.281 ms to 2.58 ms at eleven nodes, BATMAN exhibited moderate increases, and Babel experienced the highest rise.
From Fabric to Fallout: A Systematic Review of the Impact of Textile Parameters on Fibre Fragment Release
Authors: Han Jacqueline , McQueen Rachel H. , Batcheller Jane C.
Published: October 2024

With an expanding global clothing and textile industry that shows no signs of slowing, concerns over its environmental impacts follow. Fibre fragments (FFs)—short pieces of textiles that have separated from a textile construction—are a growing area of concern due to increasing evidence of their accumulation in the environment. Most of the existing research on this topic focuses on the role of consumer behaviour rather than the textiles themselves. A systematic literature review is used here to explore the key textile parameters that influence FF release. A search of articles published between 2011 and June 2024 was conducted following the PRISMA guidelines. Three databases (Scopus, Web of Science, and EBSCO) were used, and articles were screened to ensure that a minimum of one textile parameter was manipulated in the study. A total of 52 articles were selected and where appropriate, comparisons between samples used and key findings were made. The textile parameters that were found to reduce FF release include fibres of a longer length and higher tenacity, as well as filament yarns with low hairiness and higher twists. At the fabric level, tight fabric structures and high abrasion resistance show lower FF shedding. Mechanical finishes that reduce the number of protruding fibre ends or chemical finishes that increase abrasion resistance also prove to be beneficial. Lastly, sewing and cutting methods that enclose or seal the textile edge can reduce FF release. While optimal parameters have been identified, they are not applicable to all textile end-uses. Rather, these factors can serve as a guide during future production and be applied where possible to limit FF release.
The Correlation between the Elastic Modulus of the Achilles Tendon Enthesis and Bone Microstructure in the Calcaneal Crescent
Authors: Doi Kenichiro , Moazamian Dina , Namiranian Behnam , Statum Sheronda , Afsahi Amir Masoud , Yamamoto Takuaki , Cheng Karen Y. , Chung Christine B. , Jerban Saeed
Published: October 2024

Background: The calcaneal enthesis, an osseous footprint where the Achilles tendon seamlessly integrates with the bone, represents a complex interface crucial for effective force transmission. Bone adapts to mechanical stress and remodels based on the applied internal and external forces. This study explores the relationship between the elasticity of the Achilles tendon enthesis and the bone microstructure in the calcaneal crescent. Methods: In total, 19 calcaneal-enthesis sections, harvested from 10 fresh-frozen human cadaveric foot-ankle specimens (73.8 ± 6.0 years old, seven female), were used in this study. Indentation tests were performed at the enthesis region, and Hayes’ elastic modulus was calculated for each specimen. Micro-CT scanning was performed at 50-micron voxel size to assess trabecular bone microstructure within six regions of interest (ROIs) and the cortical bone thickness along the calcaneal crescent. Results: Significant Spearman correlations were observed between the enthesis elastic modulus and trabecular bone thickness in the distal entheseal (ROI 3) and proximal plantar (ROI 4) regions (R = 0.786 and 0.518, respectively). Conclusion: This study highlights the potential impacts of Achilles tendon enthesis on calcaneal bone microstructure, which was pronounced in the distal calcaneal enthesis, suggesting regional differences in load transfer mechanism that require further investigation.
Understanding the Influencing Factors of Pro-Environmental Behavior in the Hotel Sector of Mauritius Island
Authors: Makoondlall-Chadee Toshima , Bokhoree Chandradeo
Published: October 2024

This quantitative study explored the factors influencing pro-environmental behavior (PEB) among hotel guests by integrating the Theory of Planned Behavior (TPB) with additional constructs. Data were collected from a sample of hotel guests through surveys and analyzed using both SPSS for inferential statistics and Partial Least Squares Structural Equation Modeling (PLS-SEM) for structural equation modeling. The analysis involved the assessment of measurement and structural models to ensure reliability and validity. The results revealed significant relationships between attitudes, subjective norms, perceived behavioral control, and behavioral intention toward PEB. Additionally, environmental knowledge and normative beliefs were found to play critical roles in shaping guests’ intentions. Using both SPSS and PLS-SEM provided a comprehensive understanding of the factors affecting PEB, confirming the proposed hypotheses and offering insights for promoting sustainable practices in the hospitality industry.
Searching for Hadronic Signatures in the Time Domain of Blazar Emission: The Case of Mrk 501
Authors: Chatzis Margaritis , Stathopoulos Stamatios I. , Petropoulou Maria , Vasilopoulos Georgios
Published: October 2024

Blazars—a subclass of active galaxies—are intrinsically time-variable broadband sources of electromagnetic radiation. In this contribution, we explored relativistic proton (hadronic) signatures in the time domain blazar emission and searched for those parameter combinations that unveil their presence during flaring epochs. We generated time series for key model parameters, like magnetic field strength and the power-law index of radiating particles, which were motivated from a simulated time series with statistical properties describing the observed GeV gamma-ray flux. We chose the TeV blazar Mrk 501 as our test case, as it had been the study ground for extensive investigations during individual flaring events. Using the code LeHaMoC, we computed the electromagnetic and neutrino emissions for a period of several years that contained several flares of interest. We show that for both of those particle distributions the power-law index variations that were tied to moderate changes in the magnetic field strength of the emitting region might naturally lead to hard X-ray flares with very-high-energy γ-ray counterparts. We found spectral differences measurable by the Cherenkov Telescope Array Observatory at sub-TeV energies, and we computed the neutrino fluence over 14.5 years. The latter predicted ∼0.2 muon and anti-muon neutrinos, consistent with the non-detection of high-energy neutrinos from Mrk 501.
Holothuria polii Extract as a Potential Anticoccidial Agent: Evidence of Its MUC2 Regulatory Impact in Murine Jejunum
Authors: El-Sayed Youssef A. , Abdel-Moneim Ahmed E. , Taha Rania G. , Khalil Mona F. , Abdel-Gaber Rewaida , Thagfan Felwa A. , Al-Malki Esam S. , Dkhil Mohamed A.
Published: October 2024

Eimeria is a parasite that causes coccidiosis in a variety of animals, leading to nutritional imbalances, issues with food digestion and absorption, low weight, and intestinal inflammation of varying degrees in its hosts. Anticoccidial medication resistance has become a significant obstacle to disease control efforts, leading to a renewed focus on discovering novel chemicals for alternative therapeutic approaches. The purpose of this study was to determine the efficacy of Holothuria polii extract (HpE) in treating eimeriosis in mice. Five groups of mice were studied, with E. papillata sporulated oocysts (1 × 103) used to infect three groups experimentally. The first group was treated with 200 mg/kg of HpE, the second group with Amprolium (120 mg/kg), and the third group was left untreated as a control. The fourth and fifth groups were uninfected, with one of them treated with 200 mg/kg of HpE and the other used as a negative control. The results revealed that HpE has 10 phytochemical compounds according to GC-MS analysis. Treatment with HpE resulted in a substantial decrease in oocyst output in feces. Also, the parasitic stages showed morphometric alterations, with reductions in the measurements compared with the infected, untreated mice. Moreover, expression of the mucin gene (MUC2) was higher in treated mice compared to infected ones, with significant increases in goblet cell numbers, which provided additional evidence for the activity of HpE as an anticoccidial product. In conclusion, there are a wide variety of natural products and many have been employed in folk medicine for treating a range of parasitic diseases.
Investigation of the Theragnostic Role of KIT Expression for the Treatment of Canine Mast Cell Tumors with Tyrosine Kinase Inhibitors
Authors: De Biase Davide , De Leo Marcello , Piegari Giuseppe , d’Aquino Ilaria , Di Napoli Evaristo , Mercogliano Carmela , Calabria Alfonso , Pula Agata , Navas Luigi , Russo Valeria , Paciello Orlando
Published: October 2024

Several reports have indicated that canine MCTs express a mutated form of a tyrosine kinase receptor, namely KIT, that is involved in abnormal mast cell growth and differentiation. Currently, the post-surgical prognosis for MCTs is related to three different KIT immunohistochemical expression patterns. However, to our knowledge, there are few studies specifically exploring the efficacy of treatment with tyrosine kinase inhibitors related to KIT staining pattern. The purpose of this study was to investigate the potential theragnostic role of KIT expression patterns by studying their correlation to the overall survival and progression-free survival in dogs treated with only tyrosine kinase inhibitors immediately after surgery. We selected 66 cases of canine cutaneous MCTs with complete clinical background. A statistical analysis was performed to assess the overall survival status. Our data suggest an important role of KIT in the etiopathogenesis of canine MCTs and indicate that the anomalous cytoplasmatic distribution of KIT is potentially related to a lower efficacy of tyrosine kinase inhibitors, thus providing a significant prognostic information about the treatment outcome.
Mechanical Response Study of a Cross-Fault Water Conveyance Tunnel under the Combined Action of Faulting Dislocation and Seismic Loading
Authors: Zhang Maochu , Yan Tianyou , Cui Zhen , Li Jianhe , Xu Ran
Published: October 2024

This paper investigated the response of a cross-fault water conveyance tunnel under the combined action of faulting dislocation and seismic loading. The current work studied the mechanical properties of the wall rock–lining contact surface. Finite difference method (FDM) code was used for the numerical simulation test to reproduce the shear test and calibrate the parameters. In the analysis of the combined faulting dislocation and strong earthquake impact on the cross-fault tunnel, the FDM was used with special consideration of the wall rock–lining interaction. The result showed that the Coulomb contact model in the FDM code could satisfactorily simulate the shear behavior of wall rock–lining contact surface. In the mechanical response calculation of the cross-fault tunnel under the faulting dislocation–seismic loading action, the magnitude of the initial faulting distance had a significant effect on the seismic relative deformation of the tunnel. The permanent deformation caused by the seismic loading increased with the initial faulting dislocation. The position of the maximum shear stress on the contact interface was related to the faulting dislocation mode, and it was distributed on the side of the tunnel squeezed by the active plate. In the high seismic risk regions with extensive development of active faults, it was necessary to consider the initial crack caused by the faulting dislocation in the stability evaluation of the cross-fault tunnel. Then, the seismic resistance study of the tunnel was followed.
Education Increasing Knowledge and Inherent Rights of Cauder and Women of Childbearing Age in the Treatment of Cancer
Authors: Yanti Yulidar , Wardhani Sri Wisnu , Pascawati Riana , Samsiah Samsiah
Published: October 2024

Introduction: Cervical cancer is one of the biggest health problems in Indonesia and is the second highest cause of death after cardiovascular disease. The high number of cervical cancer sufferers is partly caused by a lack of awareness in efforts to prevent and control cervical cancer. One way to prevent it is by providing health literacy outreach about cervical cancer to the public in the form of health education. Mortality rates and high health costs can be reduced with effective early detection, one of which is by carrying out an IVA test. To reduce the risk of women getting cervical cancer, an awareness movement is needed about the dangers of cervical cancer.
Method: The community empowerment program was carried out in the Antapani sub-district area of Bandung City by providing education about cervical cancer to 10 cadres and 10 women of childbearing age
Objective: Increase knowledge about cervical cancer and independent participation of cadres and women of childbearing age to carry out IVA test.
Results: The results of community service show an increase in the average knowledge score of 2.8 points for WUS and an increase of 3.8 points for Mitra Cadre. There is a significant difference in the pretest and posttest knowledge scores for both the women of childbearing age group and the cadre group with a p value <0.05. There has been an increase in independent participation in IVA Test examinations from 1 person to 20 people.
Conclusion: Health education using booklets as an alternative can be used as an alternative to increase knowledge about cervical cancer
 
Keywords: Knowledge, independent participation, cervical cancer prevention
Introdução da educação ambiental nas escolas - o caminho para a formação de cidadãos ecologicamente corretos
Authors: Martins Ana Júlia Alli , Madureira Maria Cecília Piva , Finati Diego
Published: October 2024

O presente artigo tem como objetivo apresentar a Educação Ambiental como uma matéria essencial no ambiente escolar, através da interdisciplinaridade e atividades dinâmicas, lúdicas e participativas. Essas práticas visam desenvolver no ser humano a consciência ambiental, promover atitudes concretas e formar cidadãos ecologicamente corretos. Para isso, revisaram-se artigos científicos que analisaram a importância de trabalhar essa temática. Um dos estudos avaliou a implementação da Educação Ambiental em duas escolas de Campina Grande (PB), revelando que os participantes foram sensibilizados e demonstraram interesse pelas questões ambientais. Atualmente, essas escolas são referências em práticas de Educação Ambiental no município.
Obesidade infantil: abordagem clínica e terapêutica na prevenção e tratamento das complicações metabólicas e cardiovasculares
Authors: Araújo Julia Figueiredo , Neto João Salviano Rosa , Silva Mayra Heringer Motta da Costa e , Oliveira Rayana Viegas
Published: October 2024

A obesidade infantil é um problema de saúde pública global em ascensão, com a prevalência triplicando nas últimas décadas, conforme relatado pela Organização Mundial da Saúde. Este artigo explora a etiopatogenia, diagnóstico e manejo da obesidade infantil. A etiologia envolve uma interação complexa entre fatores genéticos, ambientais e comportamentais. O gene FTO, por exemplo, está associado ao controle do apetite e do metabolismo energético. O ambiente, com o aumento do consumo de alimentos processados e a redução da atividade física, também contribui para o aumento da obesidade entre crianças. O diagnóstico precoce é fundamental, sendo o Índice de Massa Corporal (IMC) ajustado para idade e sexo uma ferramenta essencial para classificar o estado nutricional infantil. Além disso, a avaliação do perímetro abdominal é relevante, pois a gordura visceral está associada a um maior risco de doenças metabólicas, como diabetes tipo 2 e hipertensão. O manejo multidisciplinar da obesidade infantil inclui intervenções nutricionais, promoção de atividade física e suporte psicológico. Estudos demonstram que intervenções focadas na modificação dos hábitos alimentares e no aumento da atividade física são mais eficazes quando envolvem a família e o ambiente escolar. A educação e conscientização de pais e educadores são fatores-chave na promoção de hábitos saudáveis e na prevenção de complicações a longo prazo. Políticas públicas que criem ambientes saudáveis, como a implementação de espaços seguros para atividade física e a oferta de alimentos saudáveis nas escolas, também são essenciais para o combate à obesidade infantil. Em suma, a obesidade infantil requer uma abordagem integrada e colaborativa para seu diagnóstico e tratamento, visando prevenir as complicações metabólicas e garantir uma melhor qualidade de vida para as crianças afetadas.
Desafios e avanços no entendimento e tratamento dos transtornos alimentares: uma revisão atualizada
Authors: Fagundes Letícia Mendes , Júnior Carlos de Bessa e Silva , Silva Gabriela Campolina de Bessa e , Campigotto Roberto Spadoni
Published: October 2024

Os transtornos alimentares (TA) representam um grupo de condições psiquiátricas complexas e de alta morbimortalidade, incluindo anorexia nervosa, bulimia nervosa e transtorno de compulsão alimentar. Esses distúrbios têm etiologia multifatorial, abrangendo predisposição genética, influências ambientais e fatores biológicos e socioculturais. A fisiopatologia dos TA ainda não é totalmente compreendida, o que dificulta o desenvolvimento de tratamentos eficazes. A terapia cognitivo-comportamental (TCC) é a intervenção de primeira escolha, com algumas terapias farmacológicas sendo utilizadas de forma off-label. Estudos recentes têm explorado novas intervenções, como a neuromodulação e o uso de psicodélicos, oferecendo promissoras perspectivas para casos refratários. No entanto, a adesão ao tratamento ainda é um desafio significativo, com apenas uma pequena fração dos pacientes buscando assistência médica adequada. Este artigo revisa as evidências mais recentes sobre a fisiopatologia, comorbidades e abordagens terapêuticas para os TA, destacando as limitações dos tratamentos atuais e os avanços recentes na área. A intervenção precoce e um manejo multidisciplinar são essenciais para melhorar os desfechos dos pacientes, mas lacunas no conhecimento ainda impedem o controle ideal dessas condições. São discutidos aspectos importantes para o manejo clínico e as implicações futuras na abordagem dos transtornos alimentares.
Cistoadenoma seroso do pâncreas simulando tumor neuroendócrino: relato de caso
Authors: Veras Lara Basílio Medeiros , Teixeira Amanda Nascimento , Medeiros Thiago Soares Godim , Batista Isadora  Maria Matias , Filho Lauro Lourival Lopes , Neto Luiz Bezerra , Monteiro Thadeu do Lago Baratta , Silva André Gonçalves da , Galiza Lais Moreira de , Ribeiro João Luis Vieira
Published: October 2024

Entre as lesões císticas pancreáticas, o Cistoadenoma Seroso (CAS) pode ser encontrado com frequência na prática clínica, principalmente devido ao aumento na utilização de métodos de imagens axiais. Por tratar-se de lesão benigna e por ser assintomática na maioria dos casos, quando se apresenta de forma típica, opta-se por tratamento conservador. Entretando, algumas características de imagem do CAS podem sugerir malignidade, mimetizando, por exemplo, neoplasias mucinosas ou tumor neuroendócrino, como no caso em questão, tornando necessária a realização de cirurgia, com consequente aumento da morbidade.  O objetivo do artigo é relatar o caso de um paciente submetido a pancreatectomia devido achados suspeitos de uma lesão pancreática sugestiva de tumor neuroendócrino em exame de Ressonância Magnética (RM), que teve o diagnóstico histopatológico de CAS.  As informações foram obtidas por meio de revisão de prontuário, registro dos métodos diagnósticos e revisão de literatura.  O caso relatado, além de mostrar que existem apresentações atípicas do cistoadenoma seroso de pâncreas, dificultando seu diagnóstico baseado apenas nos exames de imagem, mostra que faz-se necessário o surgimento de novos métodos diagnósticos aplicáveis capazes de reduzir o número de cirurgias desnecessárias em alguns pacientes.
Anestesia e manejo de vias aéreas em trauma facial: revisão integrativa
Authors: Bizinotto Artur , Oliveira Danilo Brito Silva de , Castro Hermogenes Antonio Camara de , Sabino Marcus Vinícius de Souza , Rodrigues Yasmin Silva
Published: October 2024

Introdução: Pacientes com traumas faciais podem representar um cenário de maior complexidade para o manejo das vias aéreas por diversos motivos, como hemorragia, edema, lesões na coluna vertebral com mobilidade cervical limitada e distorção das vias aéreas. Dessa forma, é necessário adotar uma série de estratégias, incluindo a formação de uma equipe multidisciplinar e considerar a realização de uma intubação com o paciente acordado. Objetivo: Avaliar os métodos anestésicos utilizados em pacientes com traumas faciais e o manejo de vias aéreas difíceis. Metodologia: Trata-se de uma revisão integrativa na base de dados PUBMED, utilizando os descritores “ANESTHESIA AND (FACIAL OR MAXILLOFACIAL) AND AIRWAY MANAGEMENT AND TRAUMA” para artigos publicados entre 2019 e 2024. Resultados: É recomendado que o paciente com trauma de vias aéreas seja reavaliado nas primeiras horas, uma vez que edemas faciais e hematomas podem evoluir com o tempo. A pré-oxigenação por 3 a 5 minutos antes da intubação também é recomendada. Não existem diferenças significativas entre médicos anestesistas e emergencistas; contudo, os medicamentos utilizados podem ser cruciais na apresentação ou não de complicações. Diante da dificuldade do paciente traumatizado, técnicas alternativas, como a intubação com o paciente acordado, em pé e utilizando incisões, podem ser utilizadas. Novos estudos devem ser realizados para elucidar a segurança das técnicas alternativas. Conclusão: A abordagem de pacientes com traumas faciais que necessitam de intubação deve ser realizada de maneira completa e eficiente, com a adoção da sequência rápida de intubação. Tanto o médico intensivista quanto o anestesiologista são aptos a realizar o procedimento. Além disso, procedimentos alternativos também devem ser considerados, como a intubação nasotraqueal.
Biomarcadores na doença arterial coronariana: avanços no diagnóstico e prognóstico
Authors: Danif Mariana Nazih , Akaki Fernanda Ayumi Moreira , Boareto Pietra Paschoalino , Silva Thaila Martins
Published: October 2024

A doença arterial coronariana (DAC) é uma das principais causas de morbidade e mortalidade em todo o mundo, e a identificação de biomarcadores eficazes tem se tornado crucial para o manejo clínico. Este artigo revisa a literatura sobre a importância das troponinas, peptídeos natriuréticos e novos biomarcadores na avaliação da DAC. As troponinas I e T são reconhecidas por sua alta sensibilidade na detecção de lesões miocárdicas, enquanto os peptídeos natriuréticos, como BNP e NT-proBNP, são fundamentais na estratificação de risco em pacientes com insuficiência cardíaca. Além disso, biomarcadores inflamatórios, como mieloperoxidase, e novas frentes de pesquisa envolvendo microRNAs estão sendo explorados para potencializar as estratégias diagnósticas e terapêuticas. Este estudo sugere que a combinação de múltiplos biomarcadores pode fornecer uma avaliação mais abrangente do estado clínico dos pacientes, possibilitando intervenções mais precisas e personalizadas. A análise de dados existentes e a identificação de lacunas na literatura também são discutidas, ressaltando a necessidade de abordagens integradas no tratamento da DAC.
Epistaxe: uma revisão abrangente e atual sobre causas, classificação e manejo clínico
Authors: Névoa Ana Carolina de Lima Lopes , Oliveira Laura Santana de , Fazan Valéria Paula Sassoli , Nazareno Danielly Gomes , Vinhal Paula Lorraynne , Uemura Luise Lumi Oban , Ribeiro Eduardo Andrade , Lemes Taylane Kemelly Macedo , Souza Netto Mardem José Cordeiro , Bombarda João Vitor , Bianchin Gabriela Santos , Macedo Isadora Werner , Almeida Ana Laura Carvalho
Published: October 2024

A epistaxe, ou hemorragia nasal, é uma condição comum caracterizada pelo sangramento espontâneo das fossas nasais, resultante da ruptura de vasos sanguíneos na mucosa nasal, especialmente na área do plexo de Kiesselbach, e pode ser classificada em anterior e posterior, dependendo da localização do sangramento. Com uma incidência ao longo da vida de aproximadamente 60%, a epistaxe pode ocorrer em qualquer idade, sendo mais frequente em climas secos ou durante o inverno. Suas causas podem ser locais, como traumas e inflamações nasais, ou sistêmicas, incluindo hipertensão e uso de anticoagulantes. Embora geralmente autolimitada, em alguns casos a epistaxe requer intervenção médica imediata. O objetivo da pesquisa consistiu em analisar aspectos gerais sobre a epistaxe, assim como suas principais formas e seu manejo. A metodologia adotada envolveu a busca em bases de dados renomadas, o que gerou uma seleção preliminar de 37 artigos. Dentre esses, 23 foram considerados adequados com base nos critérios estabelecidos. A epistaxe exige uma abordagem individualizada e multifacetada, levando em consideração tanto a gravidade do sangramento quanto os fatores de risco subjacentes.
Clinical significance of normohydration state in peritoneal dialysis patients
Authors: Szabó Réka P. , Hashmi Amna Jousaf , Bujáki Boglárka , Varga István , Kardos László , Balla József , Pethő Ákos G.
Published: October 2024

Introduction: Assessing the fluid status of dialysis patients is crucial, as overhydration can lead to hypertension and left ventricular hypertrophy. Objectives: We aimed to determine the hydration of peritoneal dialysis (PD) patients by using a bioimpedance device and performing concomitant echocardiographic measurements. Patients and Methods: In our cohort, we enrolled PD patients in the study group and kidney transplantation waitlisted patients on hemodialysis (HD) or with stage 4-5 chronic kidney disease (CKD) in the control group. Fluid status was measured with a Fresenius Body Composition Monitor (BCM), and we performed an echocardiography examination. For statistical analysis, we used the Fisher’s exact test for categorical variables and the Kruskal-Wallis test for continuous variables to compare groups. Results: The patients’ average age was 47 (SD 9.45), with a mild female predominance (54.3%). Overhydration was only found in 8 (12%) patients and was related to non-significantly lower ejection fraction (EF). Follow-up found that preserved EF was a non-significantly better outcome (HR: 0.881, 95% CI interval: 0.776; 1.001, P=0.0514). PD patients had significantly lower potassium levels (P=0.0006) and more angiotensin-converting-enzyme inhibitors (ACEis) (46%) and mineralocorticoid receptor antagonists (MRAs) (26%). Conclusion: Lower potassium levels in continuous ambulatory peritoneal dialysis (CAPD) patients allow for the administration of drugs to treat cardiac remodeling and volume overload, which can help reduce patient mortality. The possible usage of MRAs in CKD could reduce cardiovascular mortality effectively.
The frequency, risk factors, onset time, and outcome of acute kidney injury induced by vancomycin, colistin, and liposomal amphotericin B in hospitalized patients
Authors: Shabani-Borujeni Mojtaba , Farvadi Fakhrossadat , Abolmaali Samira Sadat , Firouzabadi Dena , Rasaei Nakisa , Karimzadeh Iman
Published: October 2024

Introduction: Medications are among the major causes of acute kidney injury (AKI) in hospitalized patients. Objectives: This study aimed to explore the frequency, characteristics, risk factors, and clinical outcomes of AKI induced by vancomycin, colistin, and liposomal amphotericin B (L-AmB) in hospitalized patients across various wards of two educational hospitals in Shiraz, Iran. Patients and Methods: From October 2022 to May 2023, an observational cross-sectional study was conducted in both intensive care unit (ICU) and non-ICU wards of Namazi and Shahid Faghihi hospitals, Shiraz, Iran. Patients aged 18 and older, without a documented history of AKI or chronic kidney disease, scheduled to receive treatment with vancomycin, colistin, or L-AmB for at least one week, were considered eligible. Relevant data, including demographic, clinical, and laboratory findings, were collected. Results: AKI was observed in 36 (34.3%) out of 105 patients during treatment. The incidence rates of AKI were 29%, 55%, and 31.1% in vancomycin, colistin, and L-AmB recipients, respectively. The mean ± SD time to AKI onset was 5.44 ± 2.04 days (range; 3 to 13 days). Dehydration at admission significantly increased the risk of antibiotic-induced AKI (odds ratio [OR] = 3.686, 95% confidence interval [CI] = 1.226–11.081, P = 0.020). Co-administration of aminoglycosides (OR = 8.422, 95% CI = 1.846 – 38.426, P = 0.006), diuretics (OR = 3.763, 95% CI = 1.092–12.965, P = 0.036), and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (OR = 7.149, 95% CI = 1.534–33.308, P = 0.012) were also identified as independent risk factors. The in-hospital mortality rate was significantly higher in patients with AKI than in those without AKI (8.6% vs. 6.7%; P < 0.044). Conclusion: AKI induced by vancomycin, colistin, and L-AmB occurred in about one-third of our study population, primarily within five days of initiating treatment. Dehydration and co-administration of nephrotoxic medications were significantly associated with AKI. Clinicians should explicitly address these factors in preventive strategies to reduce antibiotic-induced AKI in hospitalized patients.
XIII. EL ACCESO A LA LITERATURA INFANTIL ECUATORIANA: UNA BRECHA ENTRE LA ESCUELA PÚBLICA Y PRIVADA
Authors: Avecillas Almeida Julia Isabel
Published: October 2024

El acceso a la lectura deriva del derecho fundamental a la educación de calidad paratodos; y requiere del compromiso de diversos ámbitos para su desarrollo. La literaturainfantojuvenil, por su parte, se constituye en el eje fundamental para la construcción de uncanon literario escolar significativo en el ámbito de los primeros años de formación. En estemarco, el presente estudio tuvo como objetivo analizar el rol de la literatura infantojuvenilen la construcción del canon literario escolar ecuatoriano, a partir del análisis del currículonacional vigente, los libros de texto y las colecciones escolares. Metodológicamente, lainvestigación se inscribe en el paradigma cualitativo, a partir de un análisis documentalcomparativo, correspondiente a un estudio de caso, de alcance descriptivo, en que seanalizaron los principales lineamientos oficiales de promoción a la lectura instaurados por elMinisterio de Educación y el Ministerio de Cultura; al mismo tiempo que, las propuestas depromoción lectora de las editoriales privadas. Los resultados evidenciaron que el acceso a laliteratura infantojuvenil da cuenta de una brecha significativa entre la escuela pública yprivada en el Ecuador; pues únicamente el sector educativo de las escuelas particulares cuentacon la posibilidad de leer obras y autores de la LIJ nacional.
XXV. GAMIFICACIÓN EN CÁLCULO DIFERENCIAL EN EL NIVEL MEDIO SUPERIOR, RECURSO DE APRENDIZAJE
Authors: Navarrete Hernández Rosa María , Escoto Villaseñor Martha Guadalupe , Manjarrez Suárez Beatriz
Published: October 2024

Gamificar el aprendizaje en matemáticas, en la unidad de Cálculo Diferencial, parabrindar un proceso de aprender jugando, requiere activar metodologías innovadoras ymotivadoras. La gamificación radica en trasladar la mecánica de los juegos a la resoluciónde problemas propuestos de diferentes temas vistos con anterioridad y convertir ciertasactividades rutinarias en un proceso lúdico de aprendizaje para impulsar la forma natural deaprender.El diseño de materiales desarrollados ha requerido de la utilización de tecnologíainteractiva que permita romper la clásica presentación lineal de ejercicios matemáticos,consintiendo la experiencia del juego, involucrando, retos, competición, insignias, avatares,etc. con el fin de proporcionar una nueva experiencia de aprender en el aula.El modelo a manejar representa al ciclo holístico, organiza y relaciona los holotiposde exploración como períodos de un proceso continuo, el cuestionamiento en este procesopartiría de averiguar si, ¿La gamificación como herramienta de refuerzo en el aprendizaje dela unidad de Cálculo Diferencial, mejora el rendimiento académico de los estudiantes en laenseñanza?
XXX. INCIDENCIA DE ESTRATEGIAS METACOGNITIVAS EN LA RESOLUCIÓN DE PROBLEMAS MATEMÁTICOS
Authors: Celada Pestana Charnylsen Jesus
Published: October 2024

Esta investigación se centra en los bajos resultados que obtienen los estudiantes delprograma de Administración de Empresas de la Universidad de Sucre en la competencia deresolución de problemas matemáticos. Su objetivo general es evaluar la incidencia del usode las estrategias metacognitivas en dicha competencia. La metodología fue de tipocuantitativa con un diseño cuasiexperimental, en el cual se interviene el grupo experimentaly se comparan sus resultados de las medidas del pretest y postest con el grupo de control; losdatos son tomados a través de un cuestionario compuesto por 14 preguntas extraídas de laspruebas SABER, las cuales comprenden 3 indicadores (diseña, ejecuta y resuelve) y 3 nivelesde complejidad (I, II y III). Se complementa con un estudio de carácter cualitativo del tipoestudio de caso, en el cual se indaga sobre las estrategias metacognitivas empleadas cuandose resuelven situaciones problema. Los resultados muestran que el grupo experimentalobtiene mejores puntajes, sin embargo, para el indicador ejecuta y niveles de dificultad II yIII este incremento no es estadísticamente significativo, como si sucede con los indicadoresDiseña y Resuelve y nivel de dificultad I. Estos resultados corroboran que las estrategiasmetacognitivas mejoran el desempeño en la competencia de resolución de problemas, ya quepropicia el desarrollo de habilidades orientadas a la planeación, control y evaluación de lasestrategias.
XXXIII. LA CONSTRUCCIÓN DEL SABER DIDÁCTICO EN PROBLEMAS DE REPARTO Y AGRUPAMIENTO EN 2º GRADO DE PRIMARIA
Authors: Mendoza Maldonado Jesús Manuel , González Arriaga Griselda , Mauricio Rodríguez Estrella Jatziri
Published: October 2024

Justificación: Hasta 1996 la formación inicial de profesores en México tenía comodenominador común una formación general basada en los aportes de la pedagogía, lo quealgunos autores (Bosch y Gascón, 2007) han denominado “generalismo pedagógico”. Desde1997 los sucesivos programas de formación incluyeron a la didáctica de las matemáticascomo un referente fundamental en la formación de profesores de educación primaria,específicamente los conceptos que derivan de la Teoría de las Situaciones Didácticas. ¿Cómoconstruyen los profesores en formación el saber didáctico? ¿Cómo procesan los conceptosque se trabajan durante su formación? Objetivo: Se analizan evidencias de aprendizaje de losalumnos de segundo grado, pero el propósito de la investigación radica en identificar elproceso constructivo del saber didáctico de profesores en formación. Metodología: Se tratade una investigación didáctica. Se plantearon 5 problemas matemáticos, se muestran lasestrategias informales utilizadas por niños de segundo grado ante problemas cuya estrategiade solución desconocen, así como las respuestas obtenidas de la entrevista a niños y a unadocente, destaca de esta última lo que para ella es un buen alumno. Resultados yconclusiones: Se trabajaron problemas de reparto y agrupamiento con alumnos de segundogrado, aunque la división propiamente dicha se enseña hasta en tercer grado, aparecen lasestrategias informales de los niños y las interpretaciones de una maestra en formación, esdecir, el proceso constructivo del saber didáctico.
XXXV. LA EDUCACIÓN CONTINUA EN ESTUDIANTES EN FORMACIÓN PROFESIONAL PARA ENFRENTAR EL ENTORNO LABORAL ACTUAL
Authors: Velázquez Romero Verónica , Chávez Hernández Noé
Published: October 2024

Las instituciones educativas necesitan extender sus servicios académicos a lapoblación estudiantil y egresados, como una entidad responsable en la formación,actualización y transferencia de conocimientos y experiencias que doten de capacidades a surecurso humano en preparación con la intención de ser competitivo en el entorno actual. Estetrabajo pretende analizar el interés de los estudiantes de licenciatura del Tecnológico deEstudios Superiores de Coacalco en recibir educación continua en su proceso de formaciónprofesional. También proyecta identificar las áreas de conocimiento en los que se venvulnerables ante el entorno laboral que enfrentan después de la crisis sanitaria por el COVID19. El enfoque empírico se basa en una encuesta elaborada ad hoc con una muestra de 1665estudiantes. Como principales resultados se observó que el interés de una educación continuaes relevante y con mayor atracción en alumnos que se encuentran trabajandosimultáneamente en sus estudios. Por lo consiguiente, su mayor preocupación se encaminapor una formación adicional en habilidades de lecto escritura y comprensión del inglés yemprendimiento, además de las habilidades en temas técnicos de su carrera profesional. Seconcluye que la visión por una formación continua se convierte en una necesidad imperanteen los estudiantes de pregrado que comienzan a visualizar los retos y desafíos que enfrentaranen el actual entorno laboral y la misma institución tiene un área de oportunidad paracoadyuvar en su desarrollo competitivo.
XL. LAS TIC EN LA ENSEÑANZA Y APRENDIZAJE DEL IDIOMA INGLÉS
Authors: Álvarez Martínez Julio Antonio
Published: October 2024

El sistema educativo está expuesto a diferentes cambios, uno de ellos ha sido integrarlas TIC en el proceso de enseñanza-aprendizaje en el del idioma inglés. Esto ha hecho que laformación de los estudiantes sea más significativa, ya que los conocimientos aprendidos porlos alumnos se relacionan con la realidad que los circunda. Por esta razón, es importanteinvestigar respecto al uso de las TIC en dicho proceso, (UNESCO, 2016). En esta investigaciónse realizó una revisión documental (Guirao, 2015) de carácter cualitativa- descriptiva noexperimental (Hernández, Fernández & Baptista, 2014).Se utilizaron diferentes bases de datos como Scielo, Dialnet, UNESCO, repositoriosde universidades y revistas electrónicas. Entre los resultados se destaca que: se lograronobtener 61 documentos, que fueron discriminados así: 23 artículos, 29 tesis y 9 libros (3 dela UNESCO); y las TIC en el proceso de enseñanza y aprendizaje es un tema que todavía esobjeto de estudio y seguirá siéndolo por muchos años. En cuanto a las conclusiones, laincorporación de las TIC en el proceso de enseñanza y aprendizaje ha hecho que los procesosmejoren y lleguen a muchos lugares del mundo; y la implementación de las TIC en laeducación ha abierto una brecha entre los estudiantes que tenían acceso a ella y los que no.
XLV. MODELOS DE POLÍTICAS DE PROMOCIÓN EN SALUD ORAL EN AMÉRICA LATINA, CASO DE POLÍTICAS PERUANAS
Authors: Mercado Portal Jorge , Mercado Mamani Sively , Mamani Cahuata Luz
Published: October 2024

La presente investigación que buscó contrastar los distintos modelos de políticaspúbicas aplicadas en la promoción de la salud oral, y resaltar que aspectos hacen de aquellaslas políticas más efectivas, específicamente las vinculadas a la educación en salud. Seinvestigó desde el desarrollo de una de revisión narrativa, la misma que se enmarca dentrode una búsqueda sistematizada, utilizando descriptores de búsqueda centrada en los modeloslos ejes centrales de la investigación, esa búsqueda se implementó en distintas bases de datosde reputada valoración, partiendo de criterios claves de inclusión y exclusión, los mismosque permitieron ahondar en los estudios sobre políticas en salud y educación. De loencontrado en los distintos documentos se evidencio que el proceso de promoción de la saludbucal, es un hecho de significativo en la región latinoamericana, existe todo un desarrollo depolíticas de salud muchas de ellas centradas en la sensibilización y/o promoción a partirprogramas educativos. Se concluye que realmente los modelos de promoción de la saludbucal en Latinoamérica son diversos y al mismo tiempo tienen similitudes, que es complejocompararlos en la medida de que cada país tiene un desarrollo específico sobre el tema, cadapaís tiene potencialidades y problemáticas internas dentro del desarrollo de políticas públicasque reviertan las problemáticas evidentes de la salud bucal de sus poblaciones
LI. RETOS DE LA FORMACIÓN DOCENTE DURANTE LA REVOLUCIÓN TECNOLÓGICA (CRI)
Authors: Luna Martínez Alfonso
Published: October 2024

Esta ponencia da cuenta del referente teórico conceptual de la investigación:“Recomendaciones para la formación de docentes en educación básica, frente a la RevoluciónTecnológica” en el marco del Postdoctorado en Gobernanza y Políticas Públicas AEFCM,OEI, Universidad de Alcalá, Madrid. En la misma indago y rescato el dispositivo (concentralidad en los saberes) que los docentes de educación básica en México desplegaronfrente a las emergencias educativas derivadas del advenimiento de la pandemia Covid-19;así como del contexto más amplio que representa la Cuarta Revolución Industrial. Lainvestigación en su conjunto es de corte hermenéutico-analógico y de Nuevo Realismo(construcción desarrollada desde los postulados de Beuchot, Foucault, Deleuze, Gadamer,Ferraris, Jerez y Agamben), los resultados de la misma se presentarán en posteriorescomunicaciones como sugerencias de políticas públicas formativas para docentes adecuadasal contexto referido.
III. RIESGO SANITARIO Y DE SEGURIDAD INDUSTRIAL, EN EL MANEJO INTEGRAL DE RESIDUOS SÓLIDOS PELIGROSOS DE ORIGEN HOSPITALARIO EN BUCARAMANGA
Authors: Quiroga Tasco Juan Guillermo , Silva Giraldo Cesar Augusto , Rueda Mahecha Yohanna Milena
Published: October 2024

Las actividades económicas contemplan una serie de riesgos derivados de fuentes yactos que ocasionan un deterioro en la salud de los trabajadores. En esta investigación decarácter descriptivo y enfoque cuantitativo; se realiza el análisis de los riesgos sanitarios yde seguridad industrial a los que están expuestos tres grupos de trabajadores de la ciudad deBucaramanga, quienes, en función de sus labores, manipulan residuos sólidos peligrosos deorigen hospitalario.Este estudio, tiene como objetivo conocer el comportamiento de esta problemática. Además,generar información útil para futuras investigaciones. Entre los resultados está laidentificación de la parte del cuerpo que se ve principalmente afectada y su incidencia en lacalidad de vida de las personas y el ambiente.