bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 1, Figures 1 - 8 from PLA2R1 Mediates Tumor Suppression by Activating JAK2
Authors: Vindrieux David , Augert Arnaud , Girard Christophe A. , Gitenay Delphine , Lallet-Daher Helene , Wiel Clotilde , Le Calvé Benjamin , Gras Baptiste , Ferrand Mylène , Verbeke Stéphanie , de Launoit Yvan , Leroy Xavier , Puisieux Alain , Aubert Sébastien , Perrais Michael , Gelb Michael , Simonnet Hélène , Lambeau Gérard , Bernard David
Published: April 2023

PDF file - 326K, Supplementary Figure 1: The knockdown of PLA2R1 favors OIS escape. Supplementary Figure 2: The knockdown of PLA2R1 favors transformation. Supplementary Figure 3: The knockdown of PLA2R1 favors OIS escape in human normal keratinocytes. Supplementary Figure 4: DMBA/TPA treatment induces senescence and its escape correlates with papillomas formation. Supplementary Figure 5: Validation of H-Ras mutation in papilloma. Supplementary Figure 6: JAK2 is involved in PLA2R1-mediated cell growth regulation. Supplementary Figure 7: PLA2R1 regulates JAK2 activity. -Supplementary Figure 8: JAK2 mediates PLA2R1 tumor suppressive effects.
Supplementary Tables 1 - 2 from Threshold Levels of ABL Tyrosine Kinase Inhibitors Retained in Chronic Myeloid Leukemia Cells Determine Their Commitment to Apoptosis
Authors: O'Hare Thomas , Eide Christopher A. , Agarwal Anupriya , Adrian Lauren T. , Zabriskie Matthew S. , MacKenzie Ryan J. , LaTocha Dorian H. , Johnson Kara J. , You Huihong , Luo Jenny , Riddle Steven M. , Marks Bryan D. , Vogel Kurt W. , Koop Dennis R. , Apgar John , Tyner Jeffrey W. , Deininger Michael W. , Druker Brian J.
Published: April 2023

PDF file - 337K, Summary of mean fluorescence intensity values for levels of CrkL and STAT5 phosphorylation in K562 cells following acute ABL TKI exposure followed by standard and expanded washout (S1); Kinase:inhibitor dissociation off-rates for ABL TKIs (S2).
Supplementary Figure 6 from SOX2 Expression Associates with Stem Cell State in Human Ovarian Carcinoma
Authors: Bareiss Petra M. , Paczulla Anna , Wang Hui , Schairer Rebekka , Wiehr Stefan , Kohlhofer Ursula , Rothfuss Oliver C. , Fischer Anna , Perner Sven , Staebler Annette , Wallwiener Diethelm , Fend Falko , Fehm Tanja , Pichler Bernd , Kanz Lothar , Quintanilla-Martinez Leticia , Schulze-Osthoff Klaus , Essmann Frank , Lengerke Claudia
Published: April 2023

PDF file, 112K, Apoptotic effects of staurosporine (STS) and TRAIL treatment in SOX2-modified and control Caov-3 and OVCAR-3 cells.
Supplementary Figure 5 from SOX2 Expression Associates with Stem Cell State in Human Ovarian Carcinoma
Authors: Bareiss Petra M. , Paczulla Anna , Wang Hui , Schairer Rebekka , Wiehr Stefan , Kohlhofer Ursula , Rothfuss Oliver C. , Fischer Anna , Perner Sven , Staebler Annette , Wallwiener Diethelm , Fend Falko , Fehm Tanja , Pichler Bernd , Kanz Lothar , Quintanilla-Martinez Leticia , Schulze-Osthoff Klaus , Essmann Frank , Lengerke Claudia
Published: April 2023

PDF file, 1265K, Histological and immunohistochemical analysis of explanted tumors generated from 50.000 SOX2-overexpressing and control Caov-3 cells, respectively.
Supplementary Figures 1 - 6 from Threshold Levels of ABL Tyrosine Kinase Inhibitors Retained in Chronic Myeloid Leukemia Cells Determine Their Commitment to Apoptosis
Authors: O'Hare Thomas , Eide Christopher A. , Agarwal Anupriya , Adrian Lauren T. , Zabriskie Matthew S. , MacKenzie Ryan J. , LaTocha Dorian H. , Johnson Kara J. , You Huihong , Luo Jenny , Riddle Steven M. , Marks Bryan D. , Vogel Kurt W. , Koop Dennis R. , Apgar John , Tyner Jeffrey W. , Deininger Michael W. , Druker Brian J.
Published: April 2023

PDF file - 1469K, Different ABL TKIs demonstrate potency differences in relative cellular and biochemical target inhibition (S1); Incomplete restoration of BCR-ABL signaling activity following washout of dasatinib or ponatinib tracks with intracellular drug retention and commitment to apoptosis in LAMA cells (S2); Incomplete restoration of BCR-ABL signaling activity following washout of nilotinib, imatinib, or DCC-2036 tracks with intracellular drug retention and commitment to apoptosis in LAMA cells (S3); BCR-ABL signaling is partially attenuated in conditions of continuous low concentrations of ABL TKIs that induce apoptosis (S4); Commitment to apoptosis in primary CML cells tracks with intracellular retention of ABL TKIs (S5); Intracellular retention of dasatinib, nilotinib, and imatinib is reduced following washout in primary CML cells harboring the resistant BCR-ABLT315I mutant (S6).
Supplementary Figure 4 from SOX2 Expression Associates with Stem Cell State in Human Ovarian Carcinoma
Authors: Bareiss Petra M. , Paczulla Anna , Wang Hui , Schairer Rebekka , Wiehr Stefan , Kohlhofer Ursula , Rothfuss Oliver C. , Fischer Anna , Perner Sven , Staebler Annette , Wallwiener Diethelm , Fend Falko , Fehm Tanja , Pichler Bernd , Kanz Lothar , Quintanilla-Martinez Leticia , Schulze-Osthoff Klaus , Essmann Frank , Lengerke Claudia
Published: April 2023

PDF file, 1094K, Characterization of OVCAR-3 cells transduced with the SOX2 enhancer reporter construct.
Supplementary Figure 1 from SOX2 Expression Associates with Stem Cell State in Human Ovarian Carcinoma
Authors: Bareiss Petra M. , Paczulla Anna , Wang Hui , Schairer Rebekka , Wiehr Stefan , Kohlhofer Ursula , Rothfuss Oliver C. , Fischer Anna , Perner Sven , Staebler Annette , Wallwiener Diethelm , Fend Falko , Fehm Tanja , Pichler Bernd , Kanz Lothar , Quintanilla-Martinez Leticia , Schulze-Osthoff Klaus , Essmann Frank , Lengerke Claudia
Published: April 2023

PDF file, 104K, SOX2 expression in primary human SOC.
Supplementary Figure from Chemopreventive Activity of Plant Flavonoid Isorhamnetin in Colorectal Cancer Is Mediated by Oncogenic Src and β-Catenin
Authors: Saud Shakir M. , Young Matthew R. , Jones-Hall Yava L. , Ileva Lilia , Evbuomwan Moses O. , Wise Jennifer , Colburn Nancy H. , Kim Young S. , Bobe Gerd
Published: April 2023

PDF file, 34K, Isorhamnetin has little affect on cell growth of HT29 cells on plastic, but inhibits anchor independent growth.
Supplementary Figure S5 from Peroxiredoxin-2 Represses Melanoma Metastasis by Increasing E-Cadherin/β-Catenin Complexes in Adherens Junctions
Authors: Lee Doo Jae , Kang Dong Hoon , Choi Mina , Choi Yang Ji , Lee Joo Young , Park Joo Hyun , Park Yoon Jung , Lee Kyung Wha , Kang Sang Won
Published: April 2023

Supplementary Figure S5 -�PDF file 14K, Cytotoxicity test of GT in melanoma cells
Supplementary Table 2 from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity
Authors: Wasylishen Amanda R. , Chan-Seng-Yue Michelle , Bros Christina , Dingar Dharmendra , Tu William B. , Kalkat Manpreet , Chan Pak-Kei , Mullen Peter J. , Huang Ling , Meyer Natalie , Raught Brian , Boutros Paul C. , Penn Linda Z.
Published: April 2023

XLS file, 2439K, MYC ChIP-on-chip data in MCF10A cells.
Supplementary Movie 8 from CIP4 Controls CCL19-Driven Cell Steering and Chemotaxis in Chronic Lymphocytic Leukemia
Authors: Malet-Engra Gema , Viaud Julien , Ysebaert Loïc , Farcé Manon , Lafouresse Fanny , Laurent Guy , Gaits-Iacovoni Frédérique , Scita Giorgio , Dupré Loïc
Published: April 2023

AVI file - 2015K, Supplemental Movies 6-8 shows Time-lapse video-recording of zoomed sections of the lamellipodium of a representative JVM3 cell expressing GFP-CIP4 and migrating in a CCL19 gradient. The four panels show GFP-CIP4 (green), pseudo-colour scale indicating CIP4 level, transmission and merge.
Supplementary Movie 6 from CIP4 Controls CCL19-Driven Cell Steering and Chemotaxis in Chronic Lymphocytic Leukemia
Authors: Malet-Engra Gema , Viaud Julien , Ysebaert Loïc , Farcé Manon , Lafouresse Fanny , Laurent Guy , Gaits-Iacovoni Frédérique , Scita Giorgio , Dupré Loïc
Published: April 2023

AVI file - 1602K, Supplemental Movies 6-8 shows Time-lapse video-recording of zoomed sections of the lamellipodium of a representative JVM3 cell expressing GFP-CIP4 and migrating in a CCL19 gradient. The four panels show GFP-CIP4 (green), pseudo-colour scale indicating CIP4 level, transmission and merge.
Supplementary Movie 1 from Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis
Authors: Teng Yu-Ching , Lee Cheng-Feng , Li Ying-Shiuan , Chen Yi-Ren , Hsiao Pei-Wen , Chan Meng-Yu , Lin Feng-Mao , Huang Hsien-Da , Chen Yen-Ting , Jeng Yung-Ming , Hsu Chih-Hung , Yan Qin , Tsai Ming-Daw , Juan Li-Jung
Published: April 2023

Supplementary Movie 1 � MOV file 2107K, cell moving in scramble
Supplementary Movie 2 from CIP4 Controls CCL19-Driven Cell Steering and Chemotaxis in Chronic Lymphocytic Leukemia
Authors: Malet-Engra Gema , Viaud Julien , Ysebaert Loïc , Farcé Manon , Lafouresse Fanny , Laurent Guy , Gaits-Iacovoni Frédérique , Scita Giorgio , Dupré Loïc
Published: April 2023

AVI file - 1134K, Time-lapse video-recording of a representative CIP4 knocked-down JVM3 cells exposed to a CCL19 gradient (source of CCL19 towards the bottom) over a period of 12 min.
Supplementary Table 1 from A Small-Molecule Blocking Ribonucleotide Reductase Holoenzyme Formation Inhibits Cancer Cell Growth and Overcomes Drug Resistance
Authors: Zhou Bingsen , Su Leila , Hu Shuya , Hu Weidong , Yip M.L. Richard , Wu Jun , Gaur Shikha , Smith D. Lynne , Yuan Yate-Ching , Synold Timothy W. , Horne David , Yen Yun
Published: April 2023

PDF file - 65K, NMR STD values of COH4 in complex with different hRRM2 proteins.
Supplementary Methods from A Small-Molecule Blocking Ribonucleotide Reductase Holoenzyme Formation Inhibits Cancer Cell Growth and Overcomes Drug Resistance
Authors: Zhou Bingsen , Su Leila , Hu Shuya , Hu Weidong , Yip M.L. Richard , Wu Jun , Gaur Shikha , Smith D. Lynne , Yuan Yate-Ching , Synold Timothy W. , Horne David , Yen Yun
Published: April 2023

PDF file - 99K
Supplementary Figure Legend from A Small-Molecule Blocking Ribonucleotide Reductase Holoenzyme Formation Inhibits Cancer Cell Growth and Overcomes Drug Resistance
Authors: Zhou Bingsen , Su Leila , Hu Shuya , Hu Weidong , Yip M.L. Richard , Wu Jun , Gaur Shikha , Smith D. Lynne , Yuan Yate-Ching , Synold Timothy W. , Horne David , Yen Yun
Published: April 2023

PDF file - 80K
Supplementary Figure 6 from A Small-Molecule Blocking Ribonucleotide Reductase Holoenzyme Formation Inhibits Cancer Cell Growth and Overcomes Drug Resistance
Authors: Zhou Bingsen , Su Leila , Hu Shuya , Hu Weidong , Yip M.L. Richard , Wu Jun , Gaur Shikha , Smith D. Lynne , Yuan Yate-Ching , Synold Timothy W. , Horne David , Yen Yun
Published: April 2023

PDF file - 94K, Supplemental figure 6: Activity of COH29 in HU and gemcitabine resistant cell lines.
Supplementary Figure 1 from A Small-Molecule Blocking Ribonucleotide Reductase Holoenzyme Formation Inhibits Cancer Cell Growth and Overcomes Drug Resistance
Authors: Zhou Bingsen , Su Leila , Hu Shuya , Hu Weidong , Yip M.L. Richard , Wu Jun , Gaur Shikha , Smith D. Lynne , Yuan Yate-Ching , Synold Timothy W. , Horne David , Yen Yun
Published: April 2023

PDF file - 57K, Supplemental figure 1: Pharmacophore model of COH3.
Supplementary Table from Chemoprevention of Prostate Cancer by d,l-Sulforaphane Is Augmented by Pharmacological Inhibition of Autophagy
Authors: Vyas Avani R. , Hahm Eun-Ryeong , Arlotti Julie A. , Watkins Simon , Stolz Donna Beer , Desai Dhimant , Amin Shantu , Singh Shivendra V.
Published: April 2023

PDF file, 58K, Causes for removal of some mice from the study.
Supplementary Methods from Dysregulated Expression of FOXM1 Isoforms Drives Progression of Pancreatic Cancer
Authors: Kong Xiangyu , Li Lei , Li Zhaoshen , Le Xiangdong , Huang Chen , Jia Zhiliang , Cui Jiujie , Huang Suyun , Wang Liwei , Xie Keping
Published: April 2023

PDF file - 77K, Cell scratch-wound assay; Cell migration assay; Cell invasion assay.
Supplementary Figures 1 - 7 from Dysregulated Expression of FOXM1 Isoforms Drives Progression of Pancreatic Cancer
Authors: Kong Xiangyu , Li Lei , Li Zhaoshen , Le Xiangdong , Huang Chen , Jia Zhiliang , Cui Jiujie , Huang Suyun , Wang Liwei , Xie Keping
Published: April 2023

PDF file - 1105K, Supplementary Fig. S1. FOXM1 overexpression and its direct association with clinicopathological parameters in pancreatic cancer cases. Supplementary Fig. S2. FoxM1 isoforms and PCR primers and verifications using cDNA and tumor mRNA as templates. Supplementary Fig. S3. FOXM1b, FOXM1b1, and FOXM1b2 expression in pancreatic cancer cells. Supplementary Fig. S4. Influence of altered expression of FOXM1 isoforms on pancreatic tumor growth and metastasis. Supplementary Fig. S5. Suppression of pancreatic cancer cell migration and invasion by knockdown of FOXM1 expression. Supplementary Fig. S6. FOXM1 promoter activity in pancreatic cancer cells. Supplementary Fig. S7. FOXM1c signaling in pancreatic cancer.
Supplementary Tables from A Synthetic Lethality–Based Strategy to Treat Cancers Harboring a Genetic Deficiency in the Chromatin Remodeling Factor BRG1
Authors: Oike Takahiro , Ogiwara Hideaki , Tominaga Yuichi , Ito Kentaro , Ando Osamu , Tsuta Koji , Mizukami Tatsuji , Shimada Yoko , Isomura Hisanori , Komachi Mayumi , Furuta Koh , Watanabe Shun-Ichi , Nakano Takashi , Yokota Jun , Kohno Takashi
Published: April 2023

PDF file, 106K, Supplementary Table S1. BRG1-deficient and -proficient cell lines subjected to BRM knockdown Supplementary Table S2. Verification of gene alterations in cell lines subjected to BRM knockdown Supplementary Table S3. Analysis of missense BRG1 mutations using the Polyphen software Supplementary Table S4. Negative correlation between BRG1 deficiency and alterations in therapeutic target genes in 373 NSCLC cases from three studies (this study and Refs 32 and 33) Supplementary Table S5. Correlation between BRG1 deficiency and smoking in 369 NSCLC cases from three studies (this study and Ref 32 and 33).
Supplementary Materials and Methods from A Synthetic Lethality–Based Strategy to Treat Cancers Harboring a Genetic Deficiency in the Chromatin Remodeling Factor BRG1
Authors: Oike Takahiro , Ogiwara Hideaki , Tominaga Yuichi , Ito Kentaro , Ando Osamu , Tsuta Koji , Mizukami Tatsuji , Shimada Yoko , Isomura Hisanori , Komachi Mayumi , Furuta Koh , Watanabe Shun-Ichi , Nakano Takashi , Yokota Jun , Kohno Takashi
Published: April 2023

PDF files, 147K.
Supplementary Table 2 from DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
Authors: Simon Susanne , Grabellus Florian , Ferrera Loretta , Galietta Luis , Schwindenhammer Benjamin , Mühlenberg Thomas , Taeger Georg , Eilers Grant , Treckmann Juergen , Breitenbuecher Frank , Schuler Martin , Taguchi Takahiro , Fletcher Jonathan A. , Bauer Sebastian
Published: April 2023

PDF - 42K, List of genes with strongest differential expression in GISTT1 with scrambled control versus DOG1-knockdown in cell lines.
Supplementary Materials and Methods from Obesity Promotes Breast Cancer by CCL2-Mediated Macrophage Recruitment and Angiogenesis
Authors: Arendt Lisa M. , McCready Jessica , Keller Patricia J. , Baker Dana D. , Naber Stephen P. , Seewaldt Victoria , Kuperwasser Charlotte
Published: April 2023

PDF file, 102K, Description of additional methods and procedures used in the study. Also includes supplemental references.
Supplementary Figure Legends from Obesity Promotes Breast Cancer by CCL2-Mediated Macrophage Recruitment and Angiogenesis
Authors: Arendt Lisa M. , McCready Jessica , Keller Patricia J. , Baker Dana D. , Naber Stephen P. , Seewaldt Victoria , Kuperwasser Charlotte
Published: April 2023

PDF file, 93K.
Supplementary Figure 5 from Obesity Promotes Breast Cancer by CCL2-Mediated Macrophage Recruitment and Angiogenesis
Authors: Arendt Lisa M. , McCready Jessica , Keller Patricia J. , Baker Dana D. , Naber Stephen P. , Seewaldt Victoria , Kuperwasser Charlotte
Published: April 2023

PDF file, 1009K, Characterization of SVF/EV and SVF/CCL2-derived end stage tumors.
Supplementary Figure 1 from Obesity Promotes Breast Cancer by CCL2-Mediated Macrophage Recruitment and Angiogenesis
Authors: Arendt Lisa M. , McCready Jessica , Keller Patricia J. , Baker Dana D. , Naber Stephen P. , Seewaldt Victoria , Kuperwasser Charlotte
Published: April 2023

PDF file, 945K, Adipose stromal cells synthesize lipid droplets in response to adipogenic media.
Supplementary Table 2 from Intestinal Bacteria Modify Lymphoma Incidence and Latency by Affecting Systemic Inflammatory State, Oxidative Stress, and Leukocyte Genotoxicity
Authors: Yamamoto Mitsuko L. , Maier Irene , Dang Angeline Tilly , Berry David , Liu Jared , Ruegger Paul M. , Yang Jiue-in , Soto Phillip A. , Presley Laura L. , Reliene Ramune , Westbrook Aya M. , Wei Bo , Loy Alexander , Chang Christopher , Braun Jonathan , Borneman James , Schiestl Robert H.
Published: April 2023

PDF file - 61K, Relative Abundance of Phyla of CM and RM Mice by Genotype and Intestinal Region.
Supplementary Materials and Methods from Carboxyl-Terminal Modulator Protein Positively Regulates Akt Phosphorylation and Acts as an Oncogenic Driver in Breast Cancer
Authors: Liu Yu-Peng , Liao Wen-Chi , Ger Luo-Ping , Chen Jiun-Chin , Hsu Tai-I , Lee Yu-Cheng , Chang Hong-Tai , Chen Yu-Chia , Jan Yi-Hua , Lee Kuen-Haur , Zeng Yu-Hao , Hsiao Michael , Lu Pei-Jung
Published: April 2023

PDF file, 146K.
Supplementary Methods from Intestinal Bacteria Modify Lymphoma Incidence and Latency by Affecting Systemic Inflammatory State, Oxidative Stress, and Leukocyte Genotoxicity
Authors: Yamamoto Mitsuko L. , Maier Irene , Dang Angeline Tilly , Berry David , Liu Jared , Ruegger Paul M. , Yang Jiue-in , Soto Phillip A. , Presley Laura L. , Reliene Ramune , Westbrook Aya M. , Wei Bo , Loy Alexander , Chang Christopher , Braun Jonathan , Borneman James , Schiestl Robert H.
Published: April 2023

PDF file - 53K
Supplementary Figure 2 from Intestinal Bacteria Modify Lymphoma Incidence and Latency by Affecting Systemic Inflammatory State, Oxidative Stress, and Leukocyte Genotoxicity
Authors: Yamamoto Mitsuko L. , Maier Irene , Dang Angeline Tilly , Berry David , Liu Jared , Ruegger Paul M. , Yang Jiue-in , Soto Phillip A. , Presley Laura L. , Reliene Ramune , Westbrook Aya M. , Wei Bo , Loy Alexander , Chang Christopher , Braun Jonathan , Borneman James , Schiestl Robert H.
Published: April 2023

PDF file - 94K, Effect of Oral Administration of L. johnsonii on Genotoxicity and Inflammation.
Supplementary Figure 1 from Novel Therapeutic Strategy to Prevent Chemotherapy-Induced Persistent Sensory Neuropathy By TRPA1 Blockade
Authors: Trevisan Gabriela , Materazzi Serena , Fusi Camilla , Altomare Alessandra , Aldini Giancarlo , Lodovici Maura , Patacchini Riccardo , Geppetti Pierangelo , Nassini Romina
Published: April 2023

PDF File - 24K, Chemical structure of HC-030031, the selective TRPA1 receptor antagonist and HC-067047, the selective TRPV4 receptor antagonist.
Supplementary Figure 3 from Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation
Authors: Pinho Filipa G. , Frampton Adam E. , Nunes Joao , Krell Jonathan , Alshaker Heba , Jacob Jimmy , Pellegrino Loredana , Roca-Alonso Laura , de Giorgio Alexander , Harding Victoria , Waxman Jonathan , Stebbing Justin , Pchejetski Dmitry , Castellano Leandro
Published: April 2023

PDF file, 7560K, Figure S3. SylArray enrichment analysis showing that the down-regulated genes upon miR-515-5p expression are enriched with miR-515-5p 'seeds'.
Supplementary Figure 3 from Production of Gastrointestinal Tumors in Mice by Modulating Latent TGF-β1 Activation
Authors: Shibahara Kotaro , Ota Mitsuhiko , Horiguchi Masahito , Yoshinaga Keiji , Melamed Jonathan , Rifkin Daniel B.
Published: April 2023

PDF file - 144K, Latent and active TGF-beta1 levels in tissues from mutant versus WT mice. TGF-beta1 levels in tissue (rectum) from WT, Itgb8-/-, Tgfb1C33S/C33S, and Tgfb1C33S/C33S;Itgb8-/- mice was measured by ELISA
Supplementary Figure 2 from Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation
Authors: Pinho Filipa G. , Frampton Adam E. , Nunes Joao , Krell Jonathan , Alshaker Heba , Jacob Jimmy , Pellegrino Loredana , Roca-Alonso Laura , de Giorgio Alexander , Harding Victoria , Waxman Jonathan , Stebbing Justin , Pchejetski Dmitry , Castellano Leandro
Published: April 2023

PDF file, 6751K, Figure S2. (A) SK1 mRNA expression in MCF7 cells treated with 10nM of estradiol (E2). MCF7 were treated with 10nM E2 or ethanol (negative control). After 3, 6, 12, 24 and 48 hours of treatment, SK1 mRNA levels were measured by RT-qPCR. For each time point, SK1 mRNA levels represent the ratio between the values obtained for E2 and ethanol. (B) miR-515-5p expression in ZR75-1 treated with 10nM of estradiol (E2). MCF7 were treated with 10nM E2 or ethanol (negative control). After 3, 6, 12, 24 and 48 hours of treatment, miR 515-5p levels were measured by RT-qPCR. For each time point, miR 515-5p levels represent the ratio between the values obtained for E2 and ethanol. (C) SK1 mRNA levels and phospho-ERK 1/2 protein expression in MCF7 cells treated with TAM. MCF7 cells were treated with 100nM TAM and ethanol. After 48 hours, SK1 mRNA levels were measured by RT-qPCR and (D) phospho-ERK 1/2 protein levels were analyzed by immuno-blotting. Data presented are the mean plus-minus SEM (*P<0.05; **P<0.01).
Supplementary Figure 1 from Production of Gastrointestinal Tumors in Mice by Modulating Latent TGF-β1 Activation
Authors: Shibahara Kotaro , Ota Mitsuhiko , Horiguchi Masahito , Yoshinaga Keiji , Melamed Jonathan , Rifkin Daniel B.
Published: April 2023

PDF file - 96K, Pathological Scores for Rectal Tissues in Tsp1+/-, Tsp1-/-, Tgfb1C33S/C33S;Tsp1+/- and Tgfb1C33S/C33S;Tsp1-/- Mice
Supplementary Figure 7 from Requirements for Aurora-A in Tissue Regeneration and Tumor Development in Adult Mammals
Authors: Pérez de Castro Ignacio , Aguirre-Portolés Cristina , Fernández-Miranda Gonzalo , Cañamero Marta , Cowley Dale O. , Van Dyke Terry , Malumbres Marcos
Published: April 2023

PDF file - 304KB, A low proliferation rate and an increase in nuclear volume are induced in tumors upon Aurora-A genetic ablation.
Supplementary Table 1 from Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer
Authors: Bochet Ludivine , Lehuédé Camille , Dauvillier Stéphanie , Wang Yuan Yuan , Dirat Béatrice , Laurent Victor , Dray Cédric , Guiet Romain , Maridonneau-Parini Isabelle , Le Gonidec Sophie , Couderc Bettina , Escourrou Ghislaine , Valet Philippe , Muller Catherine
Published: April 2023

PDF file, 101K, Characterization of the antibodies used in the study.
Supplementary Figure 3 from Requirements for Aurora-A in Tissue Regeneration and Tumor Development in Adult Mammals
Authors: Pérez de Castro Ignacio , Aguirre-Portolés Cristina , Fernández-Miranda Gonzalo , Cañamero Marta , Cowley Dale O. , Van Dyke Terry , Malumbres Marcos
Published: April 2023

PDF file - 77KB, In vivo consequences of Aurora-A ablation.
Supplementary Figure 1 from Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer
Authors: Bochet Ludivine , Lehuédé Camille , Dauvillier Stéphanie , Wang Yuan Yuan , Dirat Béatrice , Laurent Victor , Dray Cédric , Guiet Romain , Maridonneau-Parini Isabelle , Le Gonidec Sophie , Couderc Bettina , Escourrou Ghislaine , Valet Philippe , Muller Catherine
Published: April 2023

PDF file, 225K, The occurrence of the ADFs phenotype is reproductively observed with various human and murine breast cancer cells lines and with human mammary adipocytes.
Supplementary Figures and Tables from ERG Is a Critical Regulator of Wnt/LEF1 Signaling in Prostate Cancer
Authors: Wu Longtao , Zhao Jonathan C. , Kim Jung , Jin Hong-Jian , Wang Cun-Yu , Yu Jindan
Published: April 2023

PDF file, 272K, Figure S1. ERG induces Wnt signaling in prostate cells, which is mediated by LEF1. Figure S2. ERG and beta-catenin synergistically induce Wnt signaling. Figure S3. LEF1 is a critical mediator in ERG-induced Wnt signaling. Table S1. Antibodies that were used in this study. Table S2. Primers that were used in this study.
Supplementary Methods from Lysyl Oxidase Plays a Critical Role in Endothelial Cell Stimulation to Drive Tumor Angiogenesis
Authors: Baker Ann-Marie , Bird Demelza , Welti Jonathan C. , Gourlaouen Morgane , Lang Georgina , Murray Graeme I. , Reynolds Andrew R. , Cox Thomas R. , Erler Janine T.
Published: April 2023

PDF file - 100K, Primer sequences and detailed descriptions of immunohistochemistry, HUVEC wound closure, immunoblotting and in-vivo sponge assays. Includes supplemental references.
Supplementary Information from Conditional Loss of ErbB3 Delays Mammary Gland Hyperplasia Induced by Mutant PIK3CA without Affecting Mammary Tumor Latency, Gene Expression, or Signaling
Authors: Young Christian D. , Pfefferle Adam D. , Owens Philip , Kuba María G. , Rexer Brent N. , Balko Justin M. , Sánchez Violeta , Cheng Hailing , Perou Charles M. , Zhao Jean J. , Cook Rebecca S. , Arteaga Carlos L.
Published: April 2023

Supplementary information - PDF file 2943K, Supplementary Figure 1: Dox-induced iPIK3.iCre transgenic mouse model of PIK3CA mutant breast cancer. Supplementary Figure 2: Loss of ErbB3 delays mammary gland hyperplasia at 12 weeks. Supplementary Figure 3: IVIS Bioluminescent imaging. Supplementary Figure 4: Histology of PIK3CA-induced mammary tumors remains diverse when ErbB3 is lost. Supplementary Figure 5: Mutant PI3K binds to IRS-1, Gab1 and other tyrosinephosphorylated proteins in tumors treated with lapatinib and/or imatinib. Supplementary Figure 6: Combination of BYL719 and lapatinib delays tumor growth without causing liver toxicity
Supplementary Figure 2 from miR-205 Targets PTEN and PHLPP2 to Augment AKT Signaling and Drive Malignant Phenotypes in Non–Small Cell Lung Cancer
Authors: Cai Junchao , Fang Lishan , Huang Yongbo , Li Rong , Yuan Jie , Yang Yi , Zhu Xun , Chen Baixue , Wu Jueheng , Li Mengfeng
Published: April 2023

PDF file, 51K, Real-time analysis of miR-205 expression in H460 and H596 cells transduced with control vector or miR-205 (A), or transfected with anti-miR-186 (Anti-miR) or NC oligonucleotides (B).
Supplementary Methods, Figures 1 - 10, Tables 1 - 3 from Targeting ROR1 Inhibits Epithelial–Mesenchymal Transition and Metastasis
Authors: Cui Bing , Zhang Suping , Chen Liguang , Yu Jianqiang , Widhopf George F. , Fecteau Jessie-F. , Rassenti Laura Z. , Kipps Thomas J.
Published: April 2023

PDF file - 1112K, Supplementary Figure 1: Surface Expression Of ROR1 Associates With Breast Cancer Cell-lines That Have High-metastatic Potential. Supplementary Figure 2: High-level Expression of ROR1 In Breast Cancer Is Associated With Shorter Lung, Bone and Brain Metastasis-free Survival. Supplementary Figure 3: High-Level Expression Of ROR1 In Breast Cancer Is Associated With Shorter Metastasis-Free Survival, and Independent from their ER, PR and HER2 status. Supplementary Figure 4. Expression of ROR1 By Breast Cancer Cell Lines Is Associated With Features Of EMT. Supplementary Figure 5: Silencing ROR1 Reduces Expression Of CXCR4. Supplementary Figure 6. Silencing ROR1 Regulates EMT Genes expression. Supplementary Figure 7: Silencing ROR1 Effects Modest Late-Growth Inhibition Of Orthotopic Xenografts At The Site Of Injection But Strong Inhibition Of Experimental Pulmonary Metastases. Supplementary Figure 8: Immunohistochemistry of Experimental Metastatic Foci. Supplementary Figure 9. Silencing ROR1 Reduces Pulmonary Metastasis And Bone Metastasis Of MDA-MB-231 Derived Cell lines LM2-4175 And BoM-1833 In Vivo. Supplementary Figure 10: Silencing ROR1 Inhibits Migration Of HS-578T and BT549 Migration In Vitro. Supplementary Table 1: Summary Of Human Breast Cancer Cell Line Characteristics With Respect To EMT Status, Subgrouping, Invasiveness And Matrigel Morphology. Supplementary Table 2: Correlation Of ROR1 Status With Various Clinical Features Of Breast Cancer. Supplementary Table 3: Expression Of ROR1 Serves As An Independent Risk Factor For Short Metastasis-free Survival.
Supplementary Table 1 from Carbon Monoxide Expedites Metabolic Exhaustion to Inhibit Tumor Growth
Authors: Wegiel Barbara , Gallo David , Csizmadia Eva , Harris Clair , Belcher John , Vercellotti Gregory M. , Penacho Nuno , Seth Pankaj , Sukhatme Vikas , Ahmed Asif , Pandolfi Pier Paolo , Helczynski Leszek , Bjartell Anders , Persson Jenny Liao , Otterbein Leo E.
Published: April 2023

PDF file - 50K, Pathway analysis was performed using MetaboAnalyst 2.0.
Supplementary Figure Legend from Carbon Monoxide Expedites Metabolic Exhaustion to Inhibit Tumor Growth
Authors: Wegiel Barbara , Gallo David , Csizmadia Eva , Harris Clair , Belcher John , Vercellotti Gregory M. , Penacho Nuno , Seth Pankaj , Sukhatme Vikas , Ahmed Asif , Pandolfi Pier Paolo , Helczynski Leszek , Bjartell Anders , Persson Jenny Liao , Otterbein Leo E.
Published: April 2023

PDF file - 81K
Supplementary Figure 3 from Carbon Monoxide Expedites Metabolic Exhaustion to Inhibit Tumor Growth
Authors: Wegiel Barbara , Gallo David , Csizmadia Eva , Harris Clair , Belcher John , Vercellotti Gregory M. , Penacho Nuno , Seth Pankaj , Sukhatme Vikas , Ahmed Asif , Pandolfi Pier Paolo , Helczynski Leszek , Bjartell Anders , Persson Jenny Liao , Otterbein Leo E.
Published: April 2023

PDF file - 7319K, Effects of doxorubicin and CO on body weight and proliferation marker in tumor bearing mice.
Supplementary Figure 2 from A Transcriptional and Metabolic Signature of Primary Aneuploidy Is Present in Chromosomally Unstable Cancer Cells and Informs Clinical Prognosis
Authors: Sheltzer Jason M.
Published: April 2023

PDF file - 423K, Trisomic MEFs and human cancers are transcriptionally distinct.
Supplementary Table 1 from Angiopoietin-2 Functions as a Tie2 Agonist in Tumor Models, Where It Limits the Effects of VEGF Inhibition
Authors: Daly Christopher , Eichten Alexandra , Castanaro Carla , Pasnikowski Elizabeth , Adler Alexander , Lalani Alshad S. , Papadopoulos Nicholas , Kyle Alastair H. , Minchinton Andrew I. , Yancopoulos George D. , Thurston Gavin
Published: April 2023

PDF file - 60K, Biacore analysis of REGN910 binding to human, monkey and mouse Ang2
Supplementary Figure 2 from Angiopoietin-2 Functions as a Tie2 Agonist in Tumor Models, Where It Limits the Effects of VEGF Inhibition
Authors: Daly Christopher , Eichten Alexandra , Castanaro Carla , Pasnikowski Elizabeth , Adler Alexander , Lalani Alshad S. , Papadopoulos Nicholas , Kyle Alastair H. , Minchinton Andrew I. , Yancopoulos George D. , Thurston Gavin
Published: April 2023

PDF file - 1.2MB, Histological analysis of the effect of REGN910 on the association of tumor blood vessels with pericytes
Supplementary Figure 3 from Loss of p120-Catenin Induces Metastatic Progression of Breast Cancer by Inducing Anoikis Resistance and Augmenting Growth Factor Receptor Signaling
Authors: Schackmann Ron C.J. , Klarenbeek Sjoerd , Vlug Eva J. , Stelloo Suzan , van Amersfoort Miranda , Tenhagen Milou , Braumuller Tanya M. , Vermeulen Jeroen F. , van der Groep Petra , Peeters Ton , van der Wall Elsken , van Diest Paul J. , Jonkers Jos , Derksen Patrick W.B.
Published: April 2023

PDF - 174K, Loss of p120 does not affect Rho GTPase activity.
Supplementary Tables 1 - 2 from Therapeutic Destruction of Insulin Receptor Substrates for Cancer Treatment
Authors: Reuveni Hadas , Flashner-Abramson Efrat , Steiner Lilach , Makedonski Kirill , Song Renduo , Shir Alexei , Herlyn Meenhard , Bar-Eli Menashe , Levitzki Alexander
Published: April 2023

PDF file - 306K, Structure-activity relationship analysis that led to design of NT compounds (S1); Anti-proliferative effects of the NT compounds on various types of cancer cells (S2).
Supplementary Figures 1 - 6 from Therapeutic Destruction of Insulin Receptor Substrates for Cancer Treatment
Authors: Reuveni Hadas , Flashner-Abramson Efrat , Steiner Lilach , Makedonski Kirill , Song Renduo , Shir Alexei , Herlyn Meenhard , Bar-Eli Menashe , Levitzki Alexander
Published: April 2023

PDF file - 417K, NT compounds are allosteric inhibitors of the full-length IGF1R, and induce translocation of IRS1 to the cytoplasm (S1); The anti-proliferative effects of the NT inhibitors are maintained long after the inhibitors are washed out (S2); NT157 inhibits IGF2-induced and insulin-induced PKB activation, without inhibiting the autophosphorylation of IR and IGF1R (S3); The NT-induced Ser-phosphorylation occurs in an IGF1-independent manner (S4); NT compounds inhibit human ovarian cancer and hormonerefractory prostate cancer in xenograft models in mice (S5); Combined treatment with NT157 and PLX4032 induces a synergistic cytotoxic effect in 451-Lu melanoma cells, and NT157 reverses the overexpression of IRS1/2 in Vemurafenib-resistant Mel1617-BR cells (S6).
Supplementary Figure Legend from Therapeutic Destruction of Insulin Receptor Substrates for Cancer Treatment
Authors: Reuveni Hadas , Flashner-Abramson Efrat , Steiner Lilach , Makedonski Kirill , Song Renduo , Shir Alexei , Herlyn Meenhard , Bar-Eli Menashe , Levitzki Alexander
Published: April 2023

PDF file - 110K
Supplementary Table 2 from Tid1-L Inhibits EGFR Signaling in Lung Adenocarcinoma by Enhancing EGFR Ubiquitinylation and Degradation
Authors: Chen Chi-Yuan , Jan Chia-Ing , Lo Jeng-Fan , Yang Shuenn-Chen , Chang Yih-Leong , Pan Szu-Hua , Wang Wen-Lung , Hong Tse-Ming , Yang Pan-Chyr
Published: April 2023

PDF file - 68K, Primers used to amplify Tid1-L/S and EGFR.
Supplementary Figures 1 - 10 from Rb1 Haploinsufficiency Promotes Telomere Attrition and Radiation-Induced Genomic Instability
Authors: Gonzalez-Vasconcellos Iria , Anastasov Natasa , Sanli-Bonazzi Bahar , Klymenko Olena , Atkinson Michael J. , Rosemann Michael
Published: April 2023

PDF file - 2012K, Cre recombinase mediated deletion of the floxed Rb1 allele (S1); Characterisation of Rb1 expression in the cell lines (S2); Cre transgene expression in bone and explant cultures of primary osteoblasts (S3); Rb1 mRNA levels after transduction with shRB1-expressing lentivirus (S4); In vitro Rb1 excision using lentiviral Cre (S5); Assessment of telomere length in LV-Cre infected cells using genomic PCR (S6); Transduction with the LVRB1 leads to recovery of retinoblastoma protein expression (S7); MDM2 copy number measurement (S8); p53 expression in primary osteoblasts (S9); Formation of acentric fragments (micronuclei) after radiation exposure (S10).
Supplementary Table 1 from Tid1-L Inhibits EGFR Signaling in Lung Adenocarcinoma by Enhancing EGFR Ubiquitinylation and Degradation
Authors: Chen Chi-Yuan , Jan Chia-Ing , Lo Jeng-Fan , Yang Shuenn-Chen , Chang Yih-Leong , Pan Szu-Hua , Wang Wen-Lung , Hong Tse-Ming , Yang Pan-Chyr
Published: April 2023

PDF file - 128K, Characteristics of 20 lung adenocarcinoma patients.
Supplementary Figure 5 from Tid1-L Inhibits EGFR Signaling in Lung Adenocarcinoma by Enhancing EGFR Ubiquitinylation and Degradation
Authors: Chen Chi-Yuan , Jan Chia-Ing , Lo Jeng-Fan , Yang Shuenn-Chen , Chang Yih-Leong , Pan Szu-Hua , Wang Wen-Lung , Hong Tse-Ming , Yang Pan-Chyr
Published: April 2023

PDF file - 139K, Effect of Tid1 knockdown and overexpression on the expression of EGFR mRNA.
Supplementary Table 9 from A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-Derived Human Breast Cancer Xenograft Models
Authors: Zhang Xiaomei , Claerhout Sofie , Prat Aleix , Dobrolecki Lacey E. , Petrovic Ivana , Lai Qing , Landis Melissa D. , Wiechmann Lisa , Schiff Rachel , Giuliano Mario , Wong Helen , Fuqua Suzanne W. , Contreras Alejandro , Gutierrez Carolina , Huang Jian , Mao Sufeng , Pavlick Anne C. , Froehlich Amber M. , Wu Meng-Fen , Tsimelzon Anna , Hilsenbeck Susan G. , Chen Edward S. , Zuloaga Pavel , Shaw Chad A. , Rimawi Mothaffar F. , Perou Charles M. , Mills Gordon B. , Chang Jenny C. , Lewis Michael T.
Published: April 2023

Supplementary Table 9 � XLXS file 10K, Sequenom results
Supplementary Figure 2 from FGFR4 Promotes Stroma-Induced Epithelial-to-Mesenchymal Transition in Colorectal Cancer
Authors: Liu Rui , Li Jingyi , Xie Ke , Zhang Tao , Lei Yunlong , Chen Yi , Zhang Lu , Huang Kai , Wang Kui , Wu Hong , Wu Min , Nice Edouard C. , Huang Canhua , Wei Yuquan
Published: April 2023

PDF file, 1642K, Co-culture with TAFs induces an aggressive phenotype of colorectal cancer cells.
Data Supplement from Chromosomal Instability Selects Gene Copy-Number Variants Encoding Core Regulators of Proliferation in ER+ Breast Cancer
Authors: Endesfelder David , Burrell Rebecca A. , Kanu Nnennaya , McGranahan Nicholas , Howell Mike , Parker Peter J. , Downward Julian , Swanton Charles , Kschischo Maik
Published: April 2023

Supplementary Figure S5. Connectedness of copy number and prognostic signature expression. The absolute correlation coefficient between the copy number of the core regulators EXO1, PAQR4, TPX2 and UBE2C and the expression of each prognostic signature gene was averaged over all signature genes. The same connectedness value was computed for all the signature genes, excluding self correlations. Genes were ranked according to their connectedness.
Supplementary Figure 2 from A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer
Authors: Tang Kwan Ho , Dai Yong Dong , Tong Man , Chan Yuen Piu , Kwan Pak Shing , Fu Li , Qin Yan Ru , Tsao Sai Wah , Lung Hong Lok , Lung Maria L. , Tong Daniel K. , Law Simon , Chan Kwok Wah , Ma Stephanie , Guan Xin Yuan
Published: April 2023

PDF file - 1414K, Supplemental Figure 2. CD90, CD44 and p75NTR / CD271 expression in matched non-tumor (N) and primary ESCC (T) (n = 33) as detected by real-time qPCR.
Supplementary Figure S6 from mTOR Complex 2 Is Involved in Regulation of Cbl-Dependent c-FLIP Degradation and Sensitivity of TRAIL-Induced Apoptosis
Authors: Zhao Liqun , Yue Ping , Khuri Fadlo R. , Sun Shi-Yong
Published: April 2023

Supplementary Figure S6 PDF file - 141K, Expression of ectopic rictor interact and activates mTORC2 (A) and protects cells from TRAIL-induced apoptosis (B)
Supplementary Figure 2 from Mature Cytotoxic CD56bright/CD16+ Natural Killer Cells Can Infiltrate Lymph Nodes Adjacent to Metastatic Melanoma
Authors: Messaoudene Meriem , Fregni Giulia , Fourmentraux-Neves Emmanuelle , Chanal Johan , Maubec Eve , Mazouz-Dorval Sarra , Couturaud Benoit , Girod Angelique , Sastre-Garau Xavier , Albert Sebastien , Guédon Charles , Deschamps Lydia , Mitilian Delphine , Cremer Isabelle , Jacquelot Nicolas , Rusakiewicz Sylvie , Zitvogel Laurence , Avril Marie-Francoise , Caignard Anne
Published: April 2023

PDF file - 167K, Analyses of CD4+ Foxp3 Tregs in LN cell suspensions.
Supplementary Figures 1 through 5 from Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population
Authors: Laoui Damya , Van Overmeire Eva , Di Conza Giusy , Aldeni Chiara , Keirsse Jiri , Morias Yannick , Movahedi Kiavash , Houbracken Isabelle , Schouppe Elio , Elkrim Yvon , Karroum Oussama , Jordan Bénédicte , Carmeliet Peter , Gysemans Conny , De Baetselier Patrick , Mazzone Massimiliano , Van Ginderachter Jo A.
Published: April 2023

PDF - 410K, Molecular and functional heterogeneity of TAM and TADC subsets in 3LL-R tumors (S1); Characterization of the myeloid cell infiltrate in orthotopic 3LL-R tumors and effect of tumor growth on the lung macrophage subsets (S2); Intratumoral localization of the distinct myeloid cell subpopulations in 3LL-R tumors (S3); PHD2-haplodeficiency increases tumor vessel perfusion and vessel coverage in 3LL-R tumors (S4); Expression of hypoxia-regulated proteins in sorted TAM (S5).
Supplementary Figure Legend from Casein Kinase 1ϵ Promotes Cell Proliferation by Regulating mRNA Translation
Authors: Shin Sejeong , Wolgamott Laura , Roux Philippe P. , Yoon Sang-Oh
Published: April 2023

PDF file - 22K
Supplementary Table 1 from Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis
Authors: Martini Miriam , Russo Mariangela , Lamba Simona , Vitiello Elisa , Crowley Emily Hannah , Sassi Francesco , Romanelli Davide , Frattini Milo , Marchetti Antonio , Bardelli Alberto
Published: April 2023

PDF file - 47K, List of tumors and number of samples for each histological type used for the mutational profile of MLK4 (GIST: Gastrointestinal Stromal tumors)
Supplementary Figure 6 from TGF-β Mediates Homing of Bone Marrow–Derived Human Mesenchymal Stem Cells to Glioma Stem Cells
Authors: Shinojima Naoki , Hossain Anwar , Takezaki Tatsuya , Fueyo Juan , Gumin Joy , Gao Feng , Nwajei Felix , Marini Frank C. , Andreeff Michael , Kuratsu Jun-Ichi , Lang Frederick F.
Published: April 2023

PDF file - 2142K, Spheroids of human GSC lines.
Supplementary Figure 4 from FOXC2 Expression Links Epithelial–Mesenchymal Transition and Stem Cell Properties in Breast Cancer
Authors: Hollier Brett G. , Tinnirello Agata A. , Werden Steven J. , Evans Kurt W. , Taube Joseph H. , Sarkar Tapasree Roy , Sphyris Nathalie , Shariati Maryam , Kumar Sreedevi V. , Battula Venkata L. , Herschkowitz Jason I. , Guerra Rudy , Chang Jeffrey T. , Miura Naoyuki , Rosen Jeffrey M. , Mani Sendurai A.
Published: April 2023

Supplementary Figure 4 PDF File - 107K, Cells expressing endogenous FOXC2 exhibit increased sensitivity to sunitinib (a) Quantification of HMLE-Snail and (b) SUM159 cell viability expressing either shControl or shFOXC2, following culture for 96 hours in increasing concentrations of sunitinib. Cell viability was assessed using an MTS assay. (c) In vitro quantification of mammospheres formed by cells described above grown in the presence of sunitinib. Data represents the number of mammospheres formed per 1000 cells seeded after 7 days of culture. Error bars indicate SEM. * P<0.05
Supplementary Figure 2 from Myeloid-Specific Expression of Ron Receptor Kinase Promotes Prostate Tumor Growth
Authors: Gurusamy Devikala , Gray Jerilyn K. , Pathrose Peterson , Kulkarni Rishikesh M. , Finkleman Fred D. , Waltz Susan E.
Published: April 2023

PDF file - 80K, Ron loss in the tumor microenvironment increases macrophage cell death. For Review and Publication Both.
Supplementary Figure 5 from MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Authors: Wang Wen-Jun , Wu Si-Pei , Liu Jia-Bin , Shi Yong-Sheng , Huang Xue , Zhang Qian-Bing , Yao Kai-Tai
Published: April 2023

PDF file - 3834K, A, Tumors from xenografts after treatment for 55 days. B, Representative IHC staining of tumor samples for Ki67 and Brdu after indicated treatments
Supplementary Figure 3 from mTOR Inhibitors Block Kaposi Sarcoma Growth by Inhibiting Essential Autocrine Growth Factors and Tumor Angiogenesis
Authors: Roy Debasmita , Sin Sang-Hoon , Lucas Amy , Venkataramanan Raman , Wang Ling , Eason Anthony , Chavakula Veenadhari , Hilton Isaac B. , Tamburro Kristen M. , Damania Blossom , Dittmer Dirk P.
Published: April 2023

PDF file - 102K, Suppl. Figure 3: Reversibility of rapamycin-induced tumor inhibition in vivo supports a tumor static mechanism of action.
Supplementary Tables 1 - 2 from PME-1 Modulates Protein Phosphatase 2A Activity to Promote the Malignant Phenotype of Endometrial Cancer Cells
Authors: Wandzioch Ewa , Pusey Michelle , Werda Amy , Bail Sophie , Bhaskar Aishwarya , Nestor Mariya , Yang Jing-Jing , Rice Lyndi M.
Published: April 2023

PDF file - 340K, Table S1. siRNA and shRNA sequences targeting the gene PPME1, which codes for PME-1 protein. Table S2. Tumor and normal adjacent tissue (NAT) matched pairs were purchased from Proteogenex.
Supplementary Figure Legends from Automated Tracking of Nanoparticle-labeled Melanoma Cells Improves the Predictive Power of a Brain Metastasis Model
Authors: Sundstrøm Terje , Daphu Inderjit , Wendelbo Ingvild , Hodneland Erlend , Lundervold Arvid , Immervoll Heike , Skaftnesmo Kai Ove , Babic Michal , Jendelova Pavla , Sykova Eva , Lund-Johansen Morten , Bjerkvig Rolf , Thorsen Frits
Published: April 2023

PDF file - 47K, Includes movie legends
Supplementary Methods, Figure Legends 1-3 from Tissue Damage–Associated “Danger Signals” Influence T-cell Responses That Promote the Progression of Preneoplasia to Cancer
Authors: He Ying , Zha Jikun , Wang Yamin , Liu Wenhua , Yang Xuanming , Yu Ping
Published: April 2023

PDF file - 106K
Supplementary Figure 2 from Automated Tracking of Nanoparticle-labeled Melanoma Cells Improves the Predictive Power of a Brain Metastasis Model
Authors: Sundstrøm Terje , Daphu Inderjit , Wendelbo Ingvild , Hodneland Erlend , Lundervold Arvid , Immervoll Heike , Skaftnesmo Kai Ove , Babic Michal , Jendelova Pavla , Sykova Eva , Lund-Johansen Morten , Bjerkvig Rolf , Thorsen Frits
Published: April 2023

PDF file - 287K, Automated signal quantification flow chart
Supplementary Figures 1 - 5 from MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models
Authors: Tovar Christian , Graves Bradford , Packman Kathryn , Filipovic Zoran , Xia Brian Higgins Mingxuan , Tardell Christine , Garrido Rosario , Lee Edmund , Kolinsky Kenneth , To Kwong-Him , Linn Michael , Podlaski Frank , Wovkulich Peter , Vu Binh , Vassilev Lyubomir T.
Published: April 2023

PDF file - 1272K, Comparison of MDM2 binding properties of RG7112 and nutlin-3a (S1); Overlay of the crystal structures of MDM2 bound to RG7112 and Nutlin-2 (S2); RG7112 is a non-genotoxic p53 activator (S3); Effect of RG7112 on the viability of HCT116 cancer cells and their p53-null clone HCT116R1 (S4); RG7112 blocks the proliferation of mouse NIH-3T3 cells (S5).
Supplementary Table 1 from Identification of an Aurora Kinase Inhibitor Specific for the Aurora B Isoform
Authors: Xie Hua , Lee Mee-Hyun , Zhu Feng , Reddy Kanamata , Peng Cong , Li Yan , Lim Do Young , Joon Kim Dong , Li Xiang , Kang Soouk , Li Haitao , Ma Weiya , Lubet Ronald A. , Ding Jian , Bode Ann M. , Dong Zigang
Published: April 2023

PDF file - 73K, Kinase profiling results of HOI-07 performed by Millipore. The concentration of HOI-07 used for profiling was 5 muM
Supplementary Figure 6 from Therapeutic PD-1 Pathway Blockade Augments with Other Modalities of Immunotherapy T-Cell Function to Prevent Immune Decline in Ovarian Cancer
Authors: Duraiswamy Jaikumar , Freeman Gordon J. , Coukos George
Published: April 2023

PDF file, 23K, Upregulation of suppressive population of MDSCs and pDCs following GVAX and FVAX vaccination, respectively.
Supplementary Figure 3 from Therapeutic PD-1 Pathway Blockade Augments with Other Modalities of Immunotherapy T-Cell Function to Prevent Immune Decline in Ovarian Cancer
Authors: Duraiswamy Jaikumar , Freeman Gordon J. , Coukos George
Published: April 2023

PDF file, 27K, Expression of PD-L1 and PD-1 by TIL Tregs.
Supplementary Figure 5 from Genome-wide Profiling of AP-1–Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast Cancer
Authors: Zhao Chunyan , Qiao Yichun , Jonsson Philip , Wang Jian , Xu Li , Rouhi Pegah , Sinha Indranil , Cao Yihai , Williams Cecilia , Dahlman-Wright Karin
Published: April 2023

PDF file - 128KB, Validation of AP-1 mediated downregulation of E-cadherin expression through transcriptional induction of ZEB2 in the Hs578T TNBC cell line.
Supplementary Figure 4 from HDAC6 Inhibition Restores Ciliary Expression and Decreases Tumor Growth
Authors: Gradilone Sergio A. , Radtke Brynn N. , Bogert Pamela S. , Huang Bing Q. , Gajdos Gabriella B. , LaRusso Nicholas F.
Published: April 2023

PDF file - 28K, Cell cycle analysis
Supplementary Methods from Antitumor Activity of the Selective Pan-RAF Inhibitor TAK-632 in BRAF Inhibitor-Resistant Melanoma
Authors: Nakamura Akito , Arita Takeo , Tsuchiya Shuntarou , Donelan Jill , Chouitar Jouhara , Carideo Elizabeth , Galvin Katherine , Okaniwa Masanori , Ishikawa Tomoyasu , Yoshida Sei
Published: April 2023

PDF file - 103K
Supplementary Figure 2 from Phosphatidylinositol 4-Phosphate in the Golgi Apparatus Regulates Cell–Cell Adhesion and Invasive Cell Migration in Human Breast Cancer
Authors: Tokuda Emi , Itoh Toshiki , Hasegawa Junya , Ijuin Takeshi , Takeuchi Yukiko , Irino Yasuhiro , Fukumoto Miki , Takenawa Tadaomi
Published: April 2023

PDF file - 194K, Supplementary Figure 2. Quantification of phosphoinositides.