ОЦЕНКА ПОКАЗАТЕЛЕЙ КАЧЕСТВА ЖИЗНИ У ОПЕРИРОВАННЫХ И НЕОПЕРИРОВАННЫХ ПАЦИЕНТОВ С ПЕРВИЧНЫМ ГИПЕРПАРАТИРЕОЗОМ В СРАВНИТЕЛЬНОМ АСПЕКТЕ В РАЗЛИЧНЫЕ СРОКИ
Authors:   Tashkent Pediatric Medical Institute, NASIROVA KHURSHIDAХON К. , RIKHSIEVA NAZIRA T. ,   Tashkent Pediatric Medical Institute, URMANOVA YULDUZ M. ,   Tashkent Pediatric Medical Institute, NARIMOVA GULCHEHRA D. ,   Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Acad. Yo. Kh. Turakulov, Tashkent, SAITMURATOVA OGULDZHAN Kh. ,   Tashkent Pediatric Medical Institute, KHAIDAROVA RAVSHANOY T. ,   Center for Developing Medical Professionals’ Vocational Qualifications at the Health Ministry of the Republic of Uzbekistan, Tashkent
Published: September 2024

Introduction. The clinical picture of primary hyperparathyroidism has changed over the past decades, mainly due to the early detection of hypercalcemia, and often occurs as an asymptomatic or oligosymptomatic disease. Aim. This study aims to evaluate the quality-of-life indicators in operated and non-operated patients with primary hyperparathyroidism in a comparative aspect at various times. Materials and Methods. The present study deals with the results of treatment of children who applied to the clinic of the specialized scientific and practical medical center of endocrinology in 2012-2022, 103 children with suspected primary hyperparathyroidism were examined according to anamnesis, outpatient cards, and detailed procedure reports. From among them, 90 children and adolescents with primary hyperparathyroidism were selected, where 50 patients are in the 1st group (after surgery) and 40 children and adolescences with primary hyperparathyroidism are in the 2nd group (no surgery). Numerical values obtained as a result of scientific research were statistically processed using MS Excel, arithmetic mean (M), mean standard error (m), standard deviation (Ϭ), relative values (% agreement), and Student’s t-test (t). Results and Discussion. It was found that the quality-of-life indicators in patients with primary hyperparathyroidism were significantly lower than in the control group, to a greater extent due to pain, general health, social functioning, and vitality (p<0.05). Thus, in patients with primary hyperparathyroidism before surgery, a significant violation of both: the physical and mental components of the quality-of-life was established. Further, in the 1st group of patients with surgical treatment, in dynamics after 3 and 6 months, all quality-of-life indicators according to SF-36 were significantly closer to the control group in all domains. In the 2nd group of patients with conservative treatment in dynamics after 3, 6, 12 months and 10 years, all quality- of-life indicators according to SF-36 remained significantly lower than in the control group in all domains and did not change significantly. Conclusions. The results obtained demonstrate the positive effect of surgical treatment from the patient’s point of view and confirm the feasibility of assessing the quality of life both at the decision-making stage when choosing a surgical approach, and as part of a comprehensive assessment of the therapy effectiveness in determining the recovery degree of various functioning aspects in patients after surgery.