bluuebunny/crossref_metadata_2025 huggingface dataset:
Real-world evidence of predictors of pathologic complete response and impact on overall survival in breast cancer patients treated with neoadjuvant chemotherapy
Authors: Antonini Marcelo , Mattar Andre , Richter Fernanda Grace Bauk , Amorim Andressa Gonçalves , Teixeira Marina Diogenes , Ramos Marcellus do Nascimento Moreira , Gebrim Luis Henrique , Lopes Reginaldo Guedes Coelho
Published: January 2024

Objective: The aim of this study was to identify predictors of pathological complete response (pCR) with an impact on overall survival (OS) in patients with breast cancer (BC) treated with neoadjuvant chemotherapy (NAC). Methodology: This is a retrospective cohort study conducted at the Centro de Referência em Saúde da Mulher – Hospital Pérola Byington and included women diagnosed with BC between 2011 and 2020. Survival data were reported using the Kaplan-Meier method, and subgroups were analyzed using the log-rank test. The study explored complete pathological responses between groups (with and without response) to identify any clinical or demographic differences. The Cox regression model will be used to analyze the relationship between independent factors and the pCR outcome, with the hazard ratio calculated. The study was approved by the Brazil Platform (CAAE 64633422.4.0000.5463). Results: The study involved 1,601 patients who underwent NAC and surgical treatment for BC. The rate of pathological complete response (pCR) in patients who received NAC was 22.8%, while the rate of non-pCR was 77.2% (p<0.0001). The 5-year prognosis for patients with pCR was better, with an OS of 89%, compared with 61.0% in non-pCR patients (log-rank p<0.0001). Factors related to pCR that had an impact on OS were premenopausal status (HR 0.79, 95%CI 0.64–0.98, p=0.032), clinical stage IIB (HR 0.66, 95%CI 0.46–0.96, p=0.029), negative hormonal receptor status (HR 1.39, 95%CI 1.13–1.71, p=0.002), and HER-2 positivity (HR 0.79, 95%CI 0.64–0.97, p=0.025). Conclusion: The pCR is a favorable prognostic factor that is associated with increased OS, especially in patients who are hormone receptor-negative, HER-2 positive, and in clinical stage IIB. These factors demonstrate a significant correlation between pCR and OS.
Tumor profile and treatment used in elderly women with breast cancer in a tertiary referral hospital
Authors: Godoi Yara Silva Alves , Vasconcelos Flávio Lúcio , Moreira Alexandre Bravin , Silva Gisele Juliana , Cardoso Glydeane , Belluco Rosana Zabulon Feijó , Perdigão Taina Maria da Silva
Published: January 2024

Objective: The aim of this study was to describe the tumor profile and treatment used in elderly women diagnosed with breast cancer treated and followed up at a tertiary referral hospital. Methodology: This is a cross-sectional study with all women aged over 60 years, survivors of breast cancer, who were being followed up at the Mastology Section of the Hospital das Forças Armadas/Brasília/Federal District/Brazil, whose consultations were carried out between January 1, 2015 to December 31, 2021. Results: There were 106 women diagnosed with breast cancer after 60 years of age, 50.94% of whom were 70 years of age or older and 93.19% were symptomatic at diagnosis. Invasive ductal carcinoma of luminal subtypes predominated. Notably, 62% were in stages I and IIa, but it was seen that, in 53.84% of the cases, mastectomies were performed and only 25.52% used immediate breast reconstruction techniques. Chemotherapy, radiotherapy, and hormone therapy were performed as indicated. Conclusion: The elderly women in this study had mostly invasive ductal carcinoma, luminal, stages I and IIa. Mastectomy with sentinel lymph node biopsy was the most commonly performed surgery with a low percentage of immediate breast reconstruction. Age did not influence the indication of adjuvant and neoadjuvant therapies.
COVID-19 and breast cancer in elderly women in Brazil
Authors: Rocha Aline Ferreira Bandeira de Melo , Freitas-Júnior Ruffo , Soares Leonardo Ribeiro , Ferreira Glalber Luiz da Rocha , Rahal Rosemar Macedo Sousa
Published: January 2024

Objective: There are no publications on the impact of the COVID-19 pandemic on screening and clinical staging of breast cancer in women over 70 years of age. In Brazil, women over 70 years of age are not the target group for whom the Unified Health System (SUS) recommends mammography screening. This study aimed to evaluate the impact of the pandemic in Brazil on screening and clinical staging of breast cancer in women of this age group. Methodology: This is an ecological time-series study. Data and trends, as well as the staging of breast cancer in older women in the SUS, from 2013 to 2021, in Brazil and its regions were analyzed. The secondary database was created with information from the Outpatient Information System of the Informatics Department of the SUS, the Oncology Brazil Panel, the Brazilian Institute of Geography and Statistics, and the Supplementary Health Agency. Results: In 2018–2019, 16,035 cases of breast cancer were reported nationwide, representing a decrease of 3.75%, and 15,434 cases were reported in 2020–2021. Screening tended to decrease with APC -7.3 (CI -11.3 to -3.2; p<0.004). The proportion of advanced cases exceeded that of initial cases in Brazil overall. There was an increasing trend for stages III and IV, with a coefficient of determination (r2 ) of 0.86 (p <0.001) and a percentage increase of 9.4% of cases (p<0.001). Conclusion: During the pandemic, there was a significant decrease in the number of mammograms and a significant increase in older patients with advanced tumors. It is important to provide screening and treatment services for breast cancer in women over 70 years of age so as not to neglect the needs of these older women.
Los árboles longevos y frondosos en la provisión de servicios ecosistémicos en ambientes urbanos
Authors: Pérez-Martinez Martha Gabriela , Perez Verdin Dr. Gustavo , López-Serrano Pablito Marcelo
Published: January 2024

Los árboles frondosos se caracterizan por su gran tamaño y longevidad, la cantidad de servicios ecosistémicos que proveen y, en ocasiones, destacan por su contribución al acervo cultural e histórico de las ciudades. El objetivo de este trabajo fue analizar el valor económico, social y ecológico que representan los árboles frondosos en la ciudad de Durango, México. A través de imágenes satelitales e inventarios de campo, se identificaron 83 árboles frondosos. Se midió el diámetro a la altura del pecho, altura, diámetro y estado de la copa, además de la temperatura y la radiación solar. Se aplicó una encuesta para conocer las percepciones sociales de la importancia de estos individuos. Los datos del inventario se analizaron en la plataforma i-Tree Eco v6 para determinar la cantidad y valor económico de los servicios ecosistémicos. Los árboles frondosos de esta ciudad secuestran alrededor de 1.3 t de CO2 por año, interceptan alrededor de 375 kg de partículas menores a 10 µm y su valor de sustitución se estimó en MXN $23.6 millones. A partir de datos tomados bajo y fuera del dosel, se calculó una diferencia de entre 400 y 1 200 Wm2 de radiación solar interceptada y de 6 a 20 °C de temperatura. Derivado del análisis factorial, las encuestas revelaron tres variables latentes: “perjuicios”, “beneficios” y “valores existenciales”. No se obtuvieron diferencias significativas en las puntuaciones factoriales de las variables. La información generada permitirá definir planes para el manejo y conservación de este tipo de ejemplares.
Comparative study of allopathy and ayurveda for treatment of diabetes mellitus
Authors: Yogesh N Sonawane  , Megha P Yeole  , Piyush V Wagh  , Mayuri A Sarode  , Sagar A Sarode  , Parag R Patil
Published: January 2024

These days, one of the most prevalent non-communicable diseases is diabetes mellitus. It has an impact on people worldwide of all ages and their families, and it heavily strains national budgets and healthcare systems. In the short term, implementing a comprehensive healthcare management program for individuals with diabetes can result in significant improvements in clinical outcomes and costs. Millions of people throughout the world suffer from diabetes mellitus, a chronic metabolic illness. To avoid complications and enhance the quality of life for those with diabetes, management is crucial. The two main methods used to treat diabetes are Ayurveda, an ancient system of traditional medicine, and Allopathy, a conventional medical system. The purpose of this study is to compare and contrast these two methods for treating diabetes. The study includes a thorough analysis of the research on diabetes treatment in allopathy and ayurveda, as well as clinical studies and expert opinions.
Youth empowerment in Africa: Lessons for U. S. youth development programs
Authors: Chioma Ann Udeh  , Rosita Eberechukwu Daraojimba  , Bukola A. Odulaja  , Jennifer Osayawe Atu Afolabi  , Damilola Emmanuel Ogedengbe  , Oladapo Olakunle James
Published: January 2024

This scholarly investigation delves into the realm of youth empowerment in Africa, aiming to distill pivotal lessons for enhancing youth development programs in the United States. Anchored in a comparative framework, the study meticulously juxtaposes African and U.S. youth empowerment paradigms, unraveling the intricate tapestry of socio-economic, cultural, and educational dynamics that shape these programs. The study meticulously analyzes various case studies of successful youth empowerment initiatives across diverse African nations. These case studies were selected based on stringent criteria, ensuring a comprehensive representation of the continent's youth empowerment landscape. The methodology eschews statistical or fieldwork analysis, instead focusing on a critical review of existing literature and program reports to glean insights into the efficacy and impact of these initiatives. Central to the findings is the burgeoning demographic of African youth, poised as a catalyst for socio-economic transformation. Despite facing formidable challenges, the study highlights how African youth empowerment programs have triumphed in fostering educational, vocational, and community engagement outcomes. These successes offer a reservoir of strategies and insights applicable to the U.S. context, particularly in enhancing community involvement and resilience among youth. The conclusion synthesizes these insights, emphasizing the transformative potential of youth empowerment in socio-economic development. Recommendations advocate for the integration of African models into U.S. youth programs, emphasizing community-centric approaches, entrepreneurship, and technological integration. This study bridges a crucial knowledge gap and serves as a beacon for future youth empowerment strategies, both in Africa and globally. It underscores the universality of youth aspirations and the power of tailored empowerment strategies in realizing these aspirations.
Pengaruh Konsumsi Telur Rebus terhadap Penyembuhan Luka Post Sectio Caesarea pada Ibu Nifas di Rsud dr. Darsono Pacitan
Authors: Dian Tatariandari  , Kurniawati Titik , Ananti Yustina
Published: January 2024

Sectio caesarea adalah persalinan dimana dinding rahim disayat melalui pembedahan untuk melahirkan janin. Proses penyembuhan luka sangat dipengaruhi oleh nutrisi, terutama protein. Salah satu makanan yang paling padat nutrisi, telur merupakan jenis lauk protein hewani yang murah, mudah ditemukan, dan ekonomis. Penelitian ini adalah penelitian kuantitatif dan menggunakan metode quasy eksperiment dengan design penelitian Nonequivalent group design. Populasi penelitian ibu nifas post section caesarea di RSUD dr. Darsono Pacitan. Teknik sampling menggunakan puposive sampling. Jumlah sampel yang digunakan sebanyak 36 ibu nifas post sectio caesarea yang dibagi dalam dua kelompok. Analisis data univariat menggunakan table distribusi frekuensi, analisis bivariat dengan uji Chi-Square. Hasil penelitian didapatkan lama penyembuhan luka post sectio caesarea pada ibu nifas yang mengkonsumsi telur rebus 18 ibu (100%) termasuk dalam kategori sembuh cepat (sembuh â‰¤ 7 hari). Lama penyembuhan luka post sectio caesarea pada ibu nifas yang tidak mengkonsumsi telur rebus di dominasi oleh ibu yang termasuk dalam kategori penyembuhan luka sembuh lambat (sembuh > 7 hari) sebanyak 10 ibu (55,6%). Hasil uji Chiâ€“Square diperoleh nilai Ï value = 0,000. Berdasarkan angka tersebut maka Ï < 0,05 maka ada pengaruh konsumsi telur rebus terhadap penyembuhan luka post sectio caesarea pada ibu nifas di RSUD dr. Darsono Pacitan.
Fate of books collections in Russian churches
Authors:   Moscow State University named after. M. V. Lomonosova, Kaliakina Aleksandra V.
Published: January 2024

Many centuries the Russian Orthodox Church was the mental leader in Russia. The Orthodox Church had monasteries and churches which accumulated many treasures. Among them were rich collections of manuscripts and books. The collections included chronicles and annals, Holy Bibles, books about Russian Saints, a lot of poems and novels. The libraries hadn’t a good condition for safety and investigation. Therefore it had many losses. The study of the collections was begun from the beginning of the 19th century. Rumyantsev Circle and the Empire Society of Russian History paid special attention to studying of the collections.
Methodological principles of Shmarov genealogical collection
Authors:   State Museum of A. S. Pushkin, Aleksandrova Natalia A.
Published: January 2024

Y. B. Shmarov collection is nominally considered to accumulate data relating to the history of Russian nobility, but it is also a pedigree reference tool in itself. The very methods of gathering and systematization of genealogical materials enable fast and efficient search options for biographical information, iconographical details, as well as both published and unpublished sources.
Filsafat progresivisme dalam pendidikan: Systematic literature review
Authors: Laksana Eko Pramudya , Indreswari Henny , Hotifah Yuliati , Anggoro Bayu Koen , Budiarto Laksono , Masruroh Betty
Published: January 2024

Filsafat progresivisme merupakan salah satu pendekatan dalam pendidikan yang menitik beratkan pembelajaran pada pembelajaran aktif, pengalaman langsung, dan perkembangan individu. Artikel ini bertujuan menyajikan kajian systematic literature review dengan metode PRISMA riset filsafat progresivisme di Indonesia, mulai dari konsep, telaah, hingga pengaplikasiannya. Jumlah artikel yang ditelaah adalah 32. Artikel tersebut diambil dari database crosreff yang kemudian disaring sesuai dengan kriteria inklusi dan eksklusi. Hasil menunjukkan bahwa filsafat progresivisme memberi pengaruh yang cukup signifikan pada dunia Pendidikan di Indonesia. Pengaruh tersebut mulai dari pengembangan kurikulum hingga pengaplikasian prinsip filsafat progresivisme.
 
 
Abstract: The philosophy of progressivism is an approach to education that focuses on active learning, direct experience, and individual development. This article aims to present a systematic literature review using the PRISMA method for progressivism philosophy research in Indonesia, starting from concept, analysis, to application. The number of articles reviewed was 32. These articles were taken from the Crossreff database which was then filtered according to inclusion and exclusion criteria. The results show that the philosophy of progressivism has had a significant influence on the world of education in Indonesia. This influence ranges from curriculum development to the application of the principles of progressivism philosophy.
History of the study of the winter bird fauna of the cities of Ukraine
Authors:   Ivan Franko National University of Lviv, Zhulenko V. , Shydlovskyy I. ,   Ivan Franko National University of Lviv
Published: January 2024

Knowledge of wintering avifauna and the study of wintering aspects of birds make it possible to obtain information about the diversity and status of the populations of birds during one of the most unfavorable periods of their life. Significant changes in climatic conditions in winter period during the last decades in Europe are noticeable. They affect winter distribution and dynamics of a number of bird species. In particular, new species appear, what may be caused by changes in wintering places or migration routes, or birds that were previously migratory remain for the wintering. Therefore, systematic research of winter avifauna in the territory of urban agglomerations of different levels is a relevant and important task for today. In our opinion, the study of winter avifauna of urban agglomerations can be classified into several groups: year-round, global, partial and selective. The vast majority of winter avifauna studies were partial, conducted by scientists specializing in the study of individual species or groups of birds. Most often, ornithologists focused their attention on predators and birds of the wetland complex. Nowadays, according to the results of research conducted by ornithologists of Ukraine, we can distinguish three distinctive stages, which are not entirely clear, but reflect the development of research on winter avifauna and are indicative in the selection of research objects and territories. The first stage is the study of wintering birds of Ukraine of large water bodies or territories, such as areas with non-freezing ponds; the second – records and study of individual species or groups of birds, in particular wintering of shrikes, representatives of the Corvidae family, and the third – direct research of avifauna in urbocoenoses. The latter stage of research is the most recent. Now, ornithologists drew their attention to avifauna changes in urban agglomerations due to the increasing urbanization rates, which may cause a decrease in the species diversity and number of birds in cities in the nearest future, as a result of their displacement and the impossibility of staying in an anthropogenic environment.
ANALISA PARTISIPASI MASYARAKAT TERHADAP KETERSEDIAAN AIR BERSIH DI KOTA MEDAN
Authors: Nanda Meutia , Chairunnisa Cindy , Br. Sitepu Rehulina Ninta , Zariah Ainun , Siregar Ayu Amanda , Hasibuan Khairunnisa , Rafif M Khaiyir
Published: January 2024

Air bersih adalah kebutuhan dasar yang sangat penting bagi kehidupan manusia. Ketersediaan air bersih yang memadai sangat berpengaruh terhadap kesehatan, sanitasi, dan kualitas hidup masyarakat. Partisipasi masyarakat merupakan aspek kunci dalam mengatasi masalah ketersediaan air bersih. Penelitian ini bertujuan untuk menganalisis faktor-faktor yang memengaruhi partisipasi masyarakat terhadap ketersediaan air bersih di Kota Medan. Jenis penelitian yang digunakan adalah kualitatif deskriptif, yakni dengan cara mewawancara (focused interviews) dan observasi alami. Lokasi penelitian dilakukan di Kota Medan. Informan penelitian adalah masyarakat Kota Medan berjumlah 25 orang. Berdasarkan hasil wawancara yang telah dilakukan pandangan mengenai penyediaan air bersih di Kota Medan memiliki beberapa analisis yang didapatkan yaitu pandangan mengenai penyediaan air bersih di Kota Medan, pandangan mengenai kesadaran masyarakat untuk menggunakan air bersih, pencemaran lingkungan menjadi momok terbesar penyediaan air bersih dan langkah konkrit dalam menaggulangi penyediaan air bersih. Kesimpulan responden mengungkapkan bahwa mereka cukup puas dengan kebijakan penyediaan air bersih yang ada di kota medan meskipun ada beberapa kendala seperti air mati ketika sedang  menggunakan air tersebut,responden mengatakan bahwa kesadaran masyarakt kota medanterhadap penyediaan dan juga kesediaan air bersih dapat dibilang baik walaupun di dalam pengaplikasianya mash terdaat berbagai kendala.
HUBUNGAN DUKUNGAN BIDAN DI MASA PANDEMI COVID-19 TERHADAP KUNJUNGAN ANTENATAL CARE DI WILAYAH KERJA PUSKESMAS SEI LANGKAI KOTA BATAM
Authors: Amru Desi Ernita , Haryati Sri Dewi
Published: January 2024

Penelitian ini bertujuan untuk mengetahui Hubungan Dukungan Bidan terhadap dengan Kunjungan Antenatal Care di Masa Pandemi Covid-19 di Wilayah Kerja Puskesmas Sei Langkai Kota Batam Tahun 2023. Penelitian ini menggunakan rancangan cross sectional dengan pendekatan retrospektif. Populasi dalam penelitian ini adalah Ibu hamil pada bulan Januari – Februari 2022 di Wilayah Kerja Puskesmas Sei Langkai Kota Batam. Sampel dalam penelitian ini sebanyak 49  orang di ambil secara purposive sampling. Variable independent adalah Dukungan bidan dan variable dependent adalah Kunjungan Antenatal Care. Instrumen penelitian menggunakan kuesioner. Pengolahan data menggunakan analisa data uji Chi Square dilanjutkan dengan Odds Ratio (OR). Hasil uji chi-square diperoleh nilai probabilitas (p-value) sebesar 0,021 artinya terdapat hubungan bermakna antara Dukungan Bidan di Masa Pandemi Covid- 19 terhadap Kunjungan Antenatal Care. Selanjutnya uji statistik, diperoleh nilai OR (Odd Ratio) sebesar 6.000 yang artinya ibu hamil mendapatkan dukungan baik dari bidan memiliki peluang 6.000 kali untuk melakukan kunjungan antenatal care secara lengkap. Kesimpulannya terdapat hubungan bermakna antara Dukungan Bidan di Masa Pandemi Covid- 19 terhadap Kunjungan Antenatal Care di Wilayah Kerja Puskesmas Sei Langkai Kota Batam. Diharapkan bidan lebih meningkatkan mutu pelayanannya, seperti lebih aktif dalam memberikan pendidikan kesehatan tentang pentingnya Antenatal care.
HUBUNGAN TINGKAT KEMANDIRIAN AKTIVITAS SEHARI-HARI DENGAN SPIRITUALITAS LANSIA DI DESA TENGGELA KABUPATEN GORONTALO
Authors: Kunding Novyanti , Febriyona Rona , Ilham Rosmin
Published: January 2024

Perubahan proses menua, salah satunya adalah perubahan fisik yang sudah terjadi penurunan fungsi dan struktur organ tubuh sehingga lansia memiliki keterbatasan untuk melakukan aktivitas sehari-hari dan menyebabkan tingkat kemandirian lansia berkurang hal ini akan berdampak juga pada spiritualitas lansia. Metode penelitian yang digunakan yakni penelitian kuantitatif dengan survey analitik dan menggunakan desain penelitian cross sectional yang digunakan untuk menentukan hubungan antara variabel bebas dan variabel terikat. Penelitian ini dilakukan di wilayah kerja Puskesmas Telaga pada bulan Agustus - Oktober 2022. Tujuan penelitian untuk mengetahui hubungan tingkat kemandirian aktivitas sehari-hari dengan spiritualitas lansia. Jenis penelitian kuantitatif, desain penelitian cross sectional dengan uji chi square. Jumlah populasi sebanyak 84 lansia pengambilan sampel menggunakan rumus sloving diperoleh sampel sebanyak 69 orang tehnik pengambilan sampel purposive sampling. Hasil analisis univariat diperoleh kemandirian lansia terbanyak yaitu kategori ketergantungan ringan sebanyak 37 lansia dengan spiritual lansia kategori sedang sebanyak 30 lansia, hasil uji chi square menunjukan nilai p=0,017<0,05. Kesimpulkan dalam penelitian ini adalah terdapat hubungan tingkat kemandirian aktivitas sehari-hari dengan spirituali lansia di Desa Tenggela Kabupaten Gorontalo. Saran diharapkan kepada lansia agar tetap meningkatkan spiritualnya agar dapat menjadi koping dalam menghadapi kemunduran fisik yang dialami dan untuk keluarga lansia agar dapat membantu lansia dalam menjaga kemampuan tubuhnya untuk beraktivitas seperti mengajak lansia untuk jalan pagi berkeliling komplek dan lainnya.
PENGARUH PEMBERIAN MINYAK ZAITUN TERHADAP RUAM POPOK (DIAPER RASH) PADA BAYI DI PMB RONNI SIREGAR DELI SERDANG TAHUN 2023
Authors: Simanjuntak Eva Hotmaria , Tarigan Suci Nanda Resti , Parapat Friska Margareth
Published: January 2024

Masa bayi juga dikenal dengan masa neonatus dimana bayi sangat rentan dengan masalah kulit, kecelakaan dan masalah fisik. Salah satu masalah yang sering terjadi pada kulit bayi dan anak adalah diaperdermatitis / diaperrash atau  sering disebut dengan ruam  popok. Penggunaan minyak zaitun lebih efektif dalam perawatan diaper rash, karena minyak zaitun mengandung asam lemak jenuh sehingga mudah masuk ke dalam lapisan kulit dalam dan mempertahankan kelenturan serta kekenyalan kulit. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian minyak zaitun (olive oil) terhadap ruam popok (diaper rash) pada bayi di PMB Ronni Siregar Kecamatan Sunggal, Kabupaten Deli serdangtahun 2022. Desain penelitian yang digunakan adalah penelitian kuantitatif dengan pendekatan Pre-Experimental Design dengan rancangan One Group Pre-test and Post-test. Jumlah sampel dalam penelitian ini yaitu 40 responden. Tehnik pengambilan sampel secara accidental sampling. Nilai rata-rata (mean) kejadian ruam popok sebelum diberikan terapi minyak zaitun adalah 2,475 sedangkan sesudah diberikan terapi minyak zaitun diperoleh rata-rata kejadian ruam popok adalah 1,350 sehingga terjadi penurunan kejadian ruam popok sebanyak 1,125 poin. Hasil penelitian menunjukkan nilai p < 0,05 dengan hasil sig (2-tailed = 0,000). Dapat disimpulkan terdapat pengaruh pemberian minyak zaitun (olive oil) terhadap ruam popok (diaper rash) pada bayi di PMB Ronni Siregar Kecamatan Sunggal, Kabupaten Deli serdangTahun 2022.
HUBUNGAN PERSEPSI RISIKO BENCANA DAN KETERIKATAN TEMPAT TERHADAP TINGKAT KESIAPSIAGAAN BENCANA ALAM TANAH LONGSOR PADA MASYARAKAT DI KELURAHAN KAYU KUBU BUKITINGGI
Authors: Suryati Ida , Murni Lilisa , Loqiana Ghina Ashil
Published: January 2024

Kelurahan Kayu Kubu Kota Bukittinggi merupakan daerah yang rawan bencana tanah longsor yang biasanya disebabkan oleh intensitas hujan yang tinggi. Beberapa alasan masyarakat pada umumnya masih menempati tempat tersebut karena sudah nyaman menempati daerah tersebut dan masyarakat sudah terbiasa dengan kejadian bencana tanah longsor di daerah itu. Selain itu, masyarakat sudah banyak mendapatkan informasi mengenai kesiapsiagaan dalam menghadapi bencana alam tanah longsor ini. Penelitian ini bertujuan untuk mengetahui hubungan persepsi risiko bencana dan keterikatan tempat terhadap tingkat kesiapsiagaan bencana alam tanah longsor pada masyarakat di Kelurahan Kayu Kubu Bukittinggi Tahun 2023. Metode penelitian deskriptif korelasional, dengan jenis penelitian cross sectional. Instrumen menggunakan kuesioner. Sampel pada penelitian ini berjumlah 74 responden dengan menggunakan teknik cluster random sampling dengan uji statistic chi square. Pada penelitian ini diperoleh hasil yaitu ada hubungan antara persepsi risiko bencana terhadap tingkat kesiapsiagaan bencana alam tanah longsor dengan p-value 0,022 (p < 0,1) dan tidak ada hubungan antara keterikatan tempat terhadap tingkat kesiapsiagaan bencana alam tanah longsor dengan p-value 0,323 (p > 0,1). Diharapkan kepada masyarakat untuk meningkatkan kesiapsiagaan bencana alam tanah longsor diwilayahnya untuk meminimalisir dampak dari risiko bencana.
PENGARUH PESAN KESEHATAN PERSUASIF DI MEDIA SOSIAL TERHADAP PERILAKU HIDUP SEHAT MAHASISWA
Authors: Licia Rizka , Susanto Agus
Published: January 2024

Fenomena perilaku hidup sehat di kalangan mahasiswa masih menjadi perhatian dalam konteks pengembangan kesadaran kesehatan melalui media sosial. Penelitian ini bertujuan untuk menguji pengaruh pesan kesehatan persuasif di media sosial terhadap perilaku hidup sehat mahasiswa. Penelitian ini menggunakan desain penelitian kuantitatif dengan pendekatan survei. Responden penelitian berjumlah 131 mahasiswa yang dipilih berdasarkan teknik sampling yang representatif. Instrumen pengumpulan data dilakukan melalui kuesioner yang mengacu pada indikator pesan kesehatan persuasif di media sosial dan perilaku hidup sehat. Data yang terkumpul dianalisis menggunakan metode Chi-Square untuk menguji hubungan antar variabel independen dengan perilaku hidup sehat serta menghitung Odds Ratio (OR) untuk menilai signifikansi pengaruh antar variabel. Hasil penelitian menunjukkan bahwa keunikan konten memiliki pengaruh signifikan terhadap perilaku hidup sehat dengan nilai p= 0,000 dan OR = 7,497. Selanjutnya, inovasi pengemasan pesan juga berpengaruh positif dengan p=0,000 dan OR = 8,182, serta interaktivitas konten dengan p=0,000 dan OR = 4,853. Daya tarik konten juga menunjukkan pengaruh signifikan dengan p= 0,013 dan OR = 2,431. Simpulan dari hasil penelitian ini adalah bahwa daya tarik pesan, keunikan konten, inovasi pengemasan pesan, dan interaktivitas konten melalui media sosial memiliki pengaruh positif terhadap perilaku hidup sehat mahasiswa. Penelitian ini menunjukkan pentingnya pendekatan komunikasi persuasif dalam membangun kesadaran perilaku sehat di lingkungan mahasiswa melalui pemanfaatan media sosial.
Gene Editing and Small Molecule Inhibitors of the RNA Binding Protein IGF2BP2/IMP2 Show its Potential as an Anti-Cancer Drug Target
Authors: Chanda Shilpee , Lepikhov Konstantin , Dahlem Charlotte , Schymik Hanna S. , Hoppstädter Jessica , Geber An-Kristin , Wagner Konrad , Kessler Sonja M. , Empting Martin , Kiemer Alexandra K.
Published: January 2024

Background: The RNA-binding protein IGF2BP2/IMP2/VICKZ2/p62 is an oncofetal protein that is overexpressed in several cancer entities. Employing IMP2 knockout colorectal cancer cells, we could show the important role of IMP2 in several hallmarks of cancer. This study aimed to functionally characterize IMP2 in lung (A549, LLC1) and hepatocellular carcinoma (HepG2, Huh7) cell lines to assess its role as a potential target for these cancer entities. Methods: IMP2 knockouts were generated by CRISPR/Cas9 and its variant approach prime editing; the editing efficiency of two single guide RNAs (sgRNAs) was verified via next-generation sequencing. We studied the effect of IMP2 knockout on cell proliferation, colony formation, and migration and employed small-molecule inhibitors of IMP2. Results: Despite multiple attempts, it was not possible to generate IMP2 biallelic knockouts in A549 and Huh7 cells. Both sgRNAs showed good editing efficiency. However, edited cells lost their ability to proliferate. The attempt to generate an IMP2 biallelic knockout in LLC1 cells using CRISPR/Cas9 was successful. Monoallelic knockout cell lines of IMP2 showed a reduction in 2D cell proliferation and reduced migration. In 3D cultures, a change in morphology from compact spheroids to loose aggregates and a distinct reduction in the colony formation ability of the IMP2 knockouts was observed, an effect that was mimicked by previously identified IMP2 inhibitor compounds that also showed an inhibitory effect on colony formation. Conclusions: Our in vitro target validation supports that IMP2 is essential for tumor cell proliferation, migration, and colony formation in several cancer entities.
MiR-145 Alleviates Sepsis-Induced Inflammatory Responses and Organ Injury by Targeting ADAM17
Authors: Lin Yingying , Liu Lizhen , Lin Yao , Yang Ruoxuan , Liao Shuanglin , Xu Mingwei , He Junbing , Liu Qinghua
Published: January 2024

Background: Current studies have demonstrated that disintegrin and metalloproteinase 17 (ADAM17) plays a critical role in the pathogenesis of sepsis. MicroRNA (miR)-145 is known to control immune responses as an anti-inflammatory modulatory molecule. However, a fundamental understanding of how miR-145 regulates ADAM17 and, more broadly, sepsis-induced inflammatory response remains unknown. Methods: We used western blotting and quantitative real-time PCR (qRT-PCR) to measure expression levels of ADAM17 and miR-145. Enzyme-linked immunosorbent assays (ELISA) were performed to measure cytokine production. To determine if ADAM17 is a target gene of miR-145, bioinformatics analyses and luciferase reporter assays were conducted. The impacts of ADAM17 and miR-145 on sepsis-induced inflammatory responses were accessed in vitro using human umbilical endothelial cells (HUVECs) treated with lipopolysaccharide (LPS). Sepsis-induced inflammatory response was measured in vivo using a polymicrobial septic mouse model induced by cecal ligation and puncture (CLP) with pre-injection of a miR-145 agomir. Results: In HUVECs treated with LPS, miR-145 expression was downregulated and miR-145 negatively regulated ADAM17 expression through direct binding to the ADAM17 transcript 3′-UTR. MiR-145 overexpression markedly reduced LPS-induced inflammatory cytokine production by targeting ADAM17 in HUVECs. In comparison to CLP-induced septic mice treated with a control agomir, treatment with a miR-145 agomir significantly reduced the expression of ADAM17, numerous downstream cytokines such as IL-6, TNF-α, IL-1β and MCP-1, and the endothelial injury factors ICAM-1, VCAM-1. The miR-145 agomir also alleviated acute lung and kidney injury and improved the survival rate of septic mice. Conclusions: This study showed that miR-145, by specifically targeting ADAM17, negatively regulates sepsis-induced inflammatory responses and vascular endothelial injury, and ultimately improved organ injury and survival during sepsis. The underlying mechanism for the regulation of ADAM17 expression by miR-145 and sepsis-induced inflammatory reactions may offer sepsis patients a novel therapeutic option.
Is media sentiment associated with future conflict events?
Authors: Jamison Anne , Hoelscher Kristian , Miklian Jason , Henisz Witold , Ganson Brian
Published: January 2024

Is media sentiment a leading indicator of conflict events? Analysis through machine learning and natural language processing techniques allows us to gather and process sentiment data at unprecedented scale, depth, and accuracy. By measuring the emotional intensity and direction of text in news reports, this baseline study shows how media sentiment analysis can deliver new value for peace and conflict research. Using GDELT’s global sample of more than five billion media articles, we test the relationship between sentiment data and conflict events. To achieve both spatial and temporal precision we utilize the PRIO-GRID data structure at daily and monthly intervals. We find that more conflictual sentiment is significantly associated with spatially and temporally proximate future conflict events as measured by the ACLED, SCAD and UCDP-GED datasets. We suggest that conflict sentiment can help us analyze conflict escalation processes more precisely.
Assessment of Solar Energy Technologies in Meeting the 2030 Agenda and Sustainable Development Goals Under an Interval-Valued Fermatean Fuzzy Environment
Authors:   School of Civil Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, P.R. China, Bouraima Mouhamed Bayane , Ibrahim Badi ,   Libyan Academy, Misrata, Libya, Qiu Yanjun ,   School of Civil Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, P.R. China, Muhammad Lawan Jibril ,   Mathematics and Computer Science Department, Federal University of Kashere, Gombe, Nigeria, Radovanović Marko ,   Military Academy, University of Defence in Belgrade, Belgrade, Serbia
Published: January 2024

Renewable energy sources, particularly solar energy, play a vital role in achieving the 2030 agenda and sustainable development goals (SDGs) in Africa. While not explicitly addressed in the millennium development goals (MDGs), renewable energy, including solar energy technologies, indirectly contributed to MDGs targets in Africa. Nevertheless, the absence of quantifiable assessments regarding the impacts of solar energy technologies, potentially attributed to limited implementation in the developing world, motivates this paper to evaluate their potential impact in Africa. The analysis, based on a two-level criteria framework and utilizing the interval-valued Fermatean fuzzy analytical hierarchy process methodology, identifies the top three potential impacts as the reduction of CO2 emissions, monetary savings, and the diminishment of air pollution.
مساهمة وسائل الاعلام الجديد في حث الجمهور على استخدام تطبيقات الذكاء الاصطناعي ( دراسة ميدانية على جمهور مدينة الكوت )
Authors: سلام زغير الغريباوي م.م
Published: January 2024

إن العالم اليوم يعيش أحداث ومتغيرات كثيرة وهذه الأحداث والمتغيرات  في الحقيقة هي نتاج  الثورة المعلوماتية  الكبيرة والذي يعدُ الذكاء الاصطناعي من أحدث افرازاتها ويهدف  بدوره للوصول الى أنظمة تتمتع بالذكاء وتتصرف  على النحو الذي يتصرف فيها البشر من حيث التعلم والفهم , وتكمن مشكلة بحثنا في معرفة مساهمة وسائل الاعلام الجديد في حث الجمهور على استخدام تطبيقات الذكاء الاصطناعي . وقد وظف الباحث الدراسة (الوصفية التحليلية) المنهج المسحي باستخدام أداة الاستبانة , وتتلخص اهداف دراستنا بكشفها  الدور الذي تلعبه شبكات التواصل الاجتماعي في حث المجتمع على استخدام تطبيقات الذكاء الاصطناعي وكذلك الكشف عن أثر مواقع التواصل الاجتماعي على استخدام تطبيقات الذكاء الاصطناعي ومعرفة أثر استخدام تطبيقات الذكاء الاصطناعي على الجمهور , إن اهمية بحثنا تكمن في تسليط الضوء على مساهمة كبيرة لوسائل الإعلام الجديد في حث الجمهور على استخدام تطبيقات الذكاء الاصطناعي ، للاستفادة  من هذه التقنية التي تفرض نفسها بقوة في خدمة المجتمع بصورة عامة في جميع  مجالات الحياة ومنها الفكرية والدينية والاجتماعية والتربوية والسلوكية , وأن نتائج  البحث قد أفرزت , أن هنالك مشاركة ومساهمة فاعلة لوسائل الأعلام الجديد في حث الجمهور على استخدام تطبيقات الذكاء الاصطناعي من خلال حصول (نعم ) على عدد تكرار ( 93) ، وحصلت على نسبة (46.5%) والتي جاءت بالمرتبة الاولى, وكذلك كشفت نتائج البحث ايضاً أن ( فيس بوك )  قد حصل على التسلسل  الاولى بين أهم أنواع (مواقع التواصل الاجتماعي) والتي ساهمت في حث الجمهور على (استخدام تطبيقات الذكاء الاصطناعي) بعدد تكرارات بلغ (90) تكراراً من بين مجموع التكرارات ، وبنسبة مئوية مقدارها (45%) من مجموع النسبة المئوية البالغة (100%).
Milliways: Taming Multiverses through Principled Evaluation of Data Analysis Paths
Authors: Sarma Abhraneel , Hwang Kyle , Hullman Jessica , Kay Matthew
Published: January 2024

Multiverse analyses involve conducting all combinations of reasonable choices in a data analysis process. A reader of a study containing a multiverse analysis might question—are all the choices included in the multiverse reasonable and equally justifiable? How much do results vary if we make different choices in the analysis process? In this work, we identify principles for validating the composition of, and interpreting the uncertainty in, the results of a multiverse analysis. We present Milliways, a novel interactive visualisation system to support principled evaluation of multiverse analyses. Milliways provides interlinked panels presenting result distributions, individual analysis composition, multiverse code specification, and data summaries. Milliways supports interactions to sort, filter and aggregate results based on the analysis specification to identify decisions in the analysis process to which the results are sensitive. To represent the two qualitatively different types of uncertainty that arise in multiverse analyses—probabilistic uncertainty from estimating unknown quantities of interest such as regression coefficients, and possibilistic uncertainty from choices in the data analysis—Milliways uses consonance curves and probability boxes. Through an evaluative study with five users familiar with multiverse analysis, we demonstrate how Milliways can support multiverse analysis tasks, including a principled assessment of the results of a multiverse analysis.
I. The Era Beyond Eisemann et al. (1984): Insect pain in the 21st century
Authors: Barrett Meghan , Fischer Bob
Published: January 2024

Can insects feel pain? In 1984, Eisemann et al. collected the best available evidence on insect neurobiology and behavior to offer a tentative answer: there appeared to be little evidence to support an adaptive role for pain perception in insects. In the intervening years, Eisemann et al. (1984) has had a significant influence on entomologists’ and the public’s understanding of insect pain, having been cited to support the lack of pain in insects in hundreds of journal and news articles, outreach efforts, pedagogical materials, and popular press books. As might be expected, however, the science related to insect pain has progressed substantially in the last four decades since its publication. Therefore, we revisit the claims made in Eisemann and demonstrate that many have been undermined by subsequent neurobiological and behavioural discoveries. Further, we briefly review the literature on new kinds of evidence not considered in Eisemann. Based on the evidence presented, we conclude that it is time to move beyond Eisemann as the definitive scientific authority on insect pain. Both academic and popular discussions of insect pain should begin engaging with more recent literature. We stress that the cumulative evidence presented herein is not intended to prove, and does not prove, that insects feel pain. However, it moves us significantly away from Eisemann’s conclusion that it is implausible, instead supporting the view that pain in insects deserves serious empirical and theoretical attention and warrants, as even Eisemann et al. supported in 1984, some application of the precautionary principle at this time.
Deployment-invariant probability of detection characterization for aerial LiDAR methane detection
Authors: Thorpe Michael , Krietinger Aaron , Altamura Dominic , Dudiak Cameron , Conrad Bradley , Tyner David , Johnson Matthew , Brasseur Jason , Roos Peter , Kunkel William , Carre-Burritt Asa , Abate Jerry , Price Tyson , Yaralian David , Kennedy Brandon , Newton Edward , Rodriguez Erik , Ibrahim Elfar Omar , Zimmerle Daniel
Published: January 2024

Accurate detection sensitivity characterization of remote methane monitoring technologies is critical for designing, implementing, and auditing effective emissions monitoring and mitigation programs. Several research groups have developed test methods based on single/double-blind controlled release protocols and regression-based data analysis techniques to create probability of detection (PoD) models for characterizing remote sensor detection sensitivities. The previously created methods and models account for some of the important factors that affect detection sensitivity, such as wind speed, and in the case of Conrad et al. flight altitude. However, these models do not account for other important factors, such as terrain albedo, variation in individual sensor performance, or spatial density of the remote sensing measurements. In this paper, we build on the work of Conrad et al. by introducing a gas concentration noise (GCN) model for Gas Mapping LiDAR aerial methane detection technology that, when combined with wind speed at the emission location, accounts for all significant sensor and environmental parameters that affect detection sensitivity for scenarios involving an isolated emission source resulting in a single methane plume. We incorporate the GCN model into Conrad et al.’s PoD model and apply it to several sets of controlled release data acquired across widely varying deployment and environmental conditions to develop PoD models for Bridger Photonics Inc.’s first- and second-generation (GML 2.0) Gas Mapping LiDAR sensors. Finally, we compare controlled release data acquired by GML 2.0 in different geographic regions and terrain cover types, in different wind conditions, deployed on different aircraft types, and with different flight parameters. Results show that the GML 2.0 PoD model remains valid regardless of the location or conditions under which the sensors are deployed, and the aircraft and flight parameters used for deployment. Based on PoD measurements in 12 production basins across North America, the average 90% PoD emission rate for sites measured by GML 2.0 in 2023 was 1.27 kg/h.
Embodied Hyperscanning for studying social interaction: A scoping review of simultaneous brain and body measurements
Authors: Grasso-Cladera Aitana , Costa-Cordella Stefanella , Mattoli-Sanchez Josefina , Vilina Erich , Santander Valentina , Hiltner Shari E. , Parada Francisco J.
Published: January 2024

This scoping review systematically investigates the application of embodied hyperscanning methodologies in neuroscience research. Hyperscanning enables the simultaneous recording of physiological signals from multiple participants. We highlight the trend towards integrating Mobile Brain/Body Imaging (MoBI) within the 4E research framework, which emphasizes the interconnectedness of brain, body, and environment in cognitive processes. Our analysis reveals a geographic concentration of hyperscanning studies in the Global North, indicating a disparity in neuroscience research distribution. This calls for global collaboration and transcultural research to balance the field. The predominant use of Electroencephalogram (EEG) in these studies suggests a traditional brain-centric perspective in social neuroscience. Future research directions should focus on integrating diverse techniques to capture the dynamic interplay between brain and body functions in real-world contexts. Our review also finds a preference for tasks involving real social interactions, aligning with the aims of social neuroscience to comprehend social behavior in natural settings. Nevertheless, the analysis in hyperscanning studies is often limited to physiological signal synchrony between participants. This suggests a need for more holistic and complex approaches that combine inter-corporeal synchrony with intra-individual measures.In conclusion, embodied hyperscanning represents a cutting-edge methodology, pushing the boundaries of our understanding of the complex interactions between the brain, body, the environment, and social behavior. Overcoming geographic and methodological constraints will enable a more nuanced and inclusive comprehension of cognitive processes. The future of the neuroscience of relationships lies in embracing the complexity of cognition, integrating diverse methods and theories to enrich our grasp of human social behavior in its natural context.
Do Not Only Count Your Chickens: Spatial Visualization is Important for Kindergarteners’ Maths Problem-solving, and Mental Rotation – for arithmetic
Authors: Likhanov Maxim , Hu Yuwei , Wang Fang , Zhou Xinlin
Published: January 2024

There is some evidence that arithmetic and maths reasoning are partly dissociated abilities, with somewhat different underlying mechanisms. However, research in the area is limited and focused mostly on schoolchildren and adults. Aim of the current study was to investigate differences in underlying mechanisms of these constructs. Three groups of preschool children: 1) Age: 60-65 months, N=152; 2) Age: 66-71 months, N=171; and 3) Age: 72-77 months, N=148; completed three spatial ability tests (2D mental rotation, paper folding and tangram puzzle), counting, arithmetic and maths reasoning tasks. Our data showed that maths reasoning was predicted by paper folding, and arithmetic was predicted by 2D mental rotation. Counting ability was a significant predictor for both tasks. Our data provided some evidence for dissociation of mechanisms that are involved in arithmetic and maths reasoning ability in preschool children. Further research is needed to provide in-depth understanding of these mechanisms at different ages.
Offensive Comment Filtering Impact on Online Engagement - A Large-Scale Randomized Controlled Trial on Nextdoor
Authors: Katsaros Matthew , Grüning David Joachim , Lou Sugin
Published: January 2024

We investigate the effectiveness of an intervention designed to hide offensive comments on the local social media platform Nextdoor. The intervention, commonly used across large social platforms, was tested through a randomized controlled trial involving 100,000 people over five months. We evaluated whether hiding offensive comments impacted twelve different measures of platform behavior including including views of offensive comments, visits to the platform, content consumption, and content production. The results showed a modest 12\% reduction in the views of offensive comments in the treatment group compared to the control group. However, we observed no significant effects of the intervention on the eleven other measured outcomes. This study provides empirical evidence on the impact of a prominent and commonly used intervention and highlights its limitation, demonstrating the complexity of effectively moderating online platforms.