bluuebunny/crossref_metadata_2025 huggingface dataset:
“Exploration and Optimization of Colletorichum lini Isolate KUMBASBT-16 for Pigment Synthesis and Appraisal of its Pigment Metabolites and their Bio-Efficacy”
Authors: Subhakar Akarsh , Gurubasajar Nandish , Veeranna Sowmya Hirakannavar , Dadayya Manjunatha , Basaiah Thippeswamy
Published: April 2024

Researchers have been exploring the use of natural colorants, particularly from filamentous fungi, to combat the carcinogenicity of synthetic dyes. The current research focused on the isolation, screening, characterization, and optimization of Colletorichum lini isolate KUMBASBT-16 for pigment production and evaluating its antimicrobial, antioxidant, and anticancer potential. The C. lini isolate KUMBASBT-16 was deposited at GenBank, NCBI (Accession No. MT994640). The desirable physico-chemical parameters for the fungus C. lini to produce maximum biomass and pigment were recorded as temperature 25°C, pH 7, carbon source: sucrose (2% W/V), nitrogen source: yeast extract (1% W/V), mineral salt: potassium phosphate (0.05% W/V) and amino acid: asparagine (0.5% W/V). The UV-Vis analysis exhibited the λmax at 390nm, FT-IR analysis transmits the frequency of different functional groups and OHR-LC/MS analysis divulges the presence of yellow-colored endogenous metabolites comprises L-pyroglutamacin, methyl-1,4-benzoquinone, and 2,2,6,6-Tetramethyl-1-piperidinol. C. lini pigment exhibited significant antimicrobial activity by inhibiting all test bacterial pathogens. Enterococcus faecalis, with an inhibition zone of 20.96 ± 0.15mm being the most susceptible. The MIC value ranged from 0.75×103 to 1.25×103µg/mL. The pigment of C. lini displayed remarkable antioxidant efficacy, i.e., DPPH+ (IC50 338.46µg/mL), ABTS•+ (IC50 117.67µg/mL), FRAP ranging from 0.251 to 2.985 and total antioxidant potential ranging from 0.078 to 1.64. C. lini pigment affects the viability of HepG2 (IC50 136.41µg/mL) and A498 (IC50 Value 138.71µg/mL) and is non-toxic to HEK-293 normal cells. The findings suggest that C. lini isolate KUMBASBT-16 can be exploited for industrial applications, potentially benefiting the pharmaceutical, food, and textile industries in the future.
Transcrestal sinus lift using Osseodensification versus lateral window technique with simultaneous implant placement
Authors: Elsaid Mohammed Gamal Abdelftah Hamed , Aboelhasan Mohsen Fawzy , Shuman Mohammad Abd Elhamied , Alashmawy Mohammed Mahgob Mohamed , Ali Hossam Eldin Mohamed , Abdelrahman Ahmed Omar Ahmed , Hassan Mohammed Ali , Elsayed Mohamed Alaa Eldin , Elwaseef Safwat Saber Mohamed Mursey Ali , Mohamed Ahmed Abouelenein Ali
Published: April 2024

Aim
The main objective of this research was to examine the outcomes of transcrestal sinus lift with simultaneous implant placement employing Osseodensification, in comparison to lateral sinus lifting methods. Patients and
Methods
Fourteen patients were enrolled in this clinical trial at the clinic of Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine, Al-Azhar University. These patients were randomized allocated into two groups. Group I: Patients who underwent transcrestal sinus floor elevation procedures utilizing osseodensification. Group II: Patients who received treatment involving Lateral Maxillary Sinus Floor Elevation. CBCT scans were acquired immediately postoperatively and at the 6-month follow-up to assess bone height, bone gain, and bone density. Osstell was utilized to evaluate primary implant stability both during the initial placement and at the six-month follow-up. The length of the surgical procedure was meticulously recorded for every group.
Results
The findings indicated that Group I exhibited a mean bone height gain of 5.33 ± 0.83mm, whereas Group II showed a gain of 10.02 ± 1.82mm, with a significant statistical difference. The average implant stability quotient (ISQ) values for Group I was 80.00 ± 3.11, compared to 75.86 ± 2.91 for Group II, also showing a statistically significant difference.
Conclusion
Crestal maxillary sinus elevation with Osseodensification shows better bone density and implant stability than lateral lifting. Osseodensification is less invasive and time-consuming, making it a potential alternative to the lateral window technique.
Bruxismo do Sono em Crianças: Causas, Consequências e Tratamento
Authors: Galdino Andresa Rayane Sarinho , Dias Brenno Anderson Santiago , Mendes Jefferson Lucas , Vasconcelos Rodrigo Gadelha , Vasconcelos Marcelo Gadelha
Published: April 2024

Introdução: O bruxismo do sono em crianças consiste no ranger dos dentes, sendo realizado por meio de movimentos repetitivos dos músculos mandibulares durante o sono. Essa parafunção é comumente associada ao desgaste dentário, cansaço e/ou dor matinal dos músculos responsáveis pela mastigação. Sua prevalência em crianças é amplamente variável, com tendência a diminuir com o aumento da idade, o que torna possível uma correlação do bruxismo em crianças com o desenvolvimento do sistema neuromuscular mastigatório. Objetivo: Discorrer, por meio de uma revisão de literatura, as características clínicas, fatores etiológicos, sinais, sintomas e tratamentos adequados para o bruxismo do sono em crianças. Metodologia: foi realizado levantamento na literatura científica nas bases de dados PubMed/Medline e SciELO. Como critério de inclusão, os artigos adotados foram aqueles que apresentaram a disponibilidade do texto integral do estudo e clareza no detalhamento metodológico. Os descritores utilizados para seleção de artigos foram: bruxismo do sono em crianças (sleep bruxism in children); tratamento para o bruxismo (bruxism treatment); fatores etiológicos do bruxismo (sleep bruxism etiology). Resultados: o tratamento ou prevenção dos sintomas do bruxismo do sono em crianças pode ser feito por meio de ajustes oclusais, tratamento farmacológico e acompanhamento psicológico, sendo imprescindível a seleção da forma de tratamento mais adequada para cada caso específico. Conclusão: É fundamental o conhecimento por parte do cirurgião dentista sobre os diversos fatores etiológicos atrelados ao acometimento do BS em crianças, para isso faz-se necessário uma boa avaliação e ajuda da família no diagnóstico, bem como no tratamento ou atenuação dos efeitos negativos que o bruxismo traz para o sistema orofacial.
Systemic inflammatory response syndrome after on-pump cardiac surgery in emergency coronary artery bypass grafting: a retrospective trial
Authors: Krichevskiy Lev А. , Dvoryadkin А. А. , Polyakov D. A. , Belyakova E. V. , Protsenko D. N.
Published: April 2024

INTRODUCTION: The frequency, spectrum and pathophysiological relationships of systemic inflammatory response syndrome in acute coronary artery bypass grafting is not fully understood. OBJECTIVE: To determine the clinical significance of systemic inflammatory response syndrome (SIRS) in emergency coronary artery bypass grafting (CABG) performed with cardiopulmonary bypass. MATERIALS AND METHODS: We examined 60 patients (38 men and 22 women, aged 65 ± 9 years) who underwent emergency CABG (3 ± 1 bypass), with cardiopulmonary bypass (CPB) (97 ± 47 min). We retrospectively studied clinical and laboratory data of the perioperative and early postoperative period from emergency and elective coronary bypass surgery. RESULTS: In urgently operated patients (n = 30) in the early postoperative period, a higher frequency (53.3 and 13.3 %; p = 0.0022) of the development of systemic manifestations of the inflammatory response (neutrophilic leukocytosis, fever, postperfusion vasoplegia), as well as respiratory complications (70 and 10 %; p < 0.001) was noted. A pathophysiological relationship was established between the manifestations of SIRS and respiratory dysfunction during emergency interventions. CONCLUSIONS: SIRS pathophysiologically associated with respiratory dysfunction is characteristic of emergency CABG. It is during emergency myocardial revascularization that the duration of cardiopulmonary bypass and myocardial ischemia (MI) are predictors of SIRS.
Some features of the perioperative management of patients with a tumor of the chiasmal cellaric region: a review
Authors: Tsentsiper Lyubov M. , Petrova A. O. , Terekhov I. S. , Leyderman I. N. , Gulyaev D. A. , Ulitin A. Yu. , Samochernykh K. A. , Kondratyev A. N.
Published: April 2024

INTRODUCTION: Tumors of the chiasmal-sellar region (CSR) account for more than 20 % of all primary intracranial neoplasms, of which pituitary adenomas account for up to 20 % of the world population. Currently, removal of these neoplasms is performed using endoscopic transsphenoidal surgical accesses. OBJECTIVE: analysis of the results of publications concerning perioperative management of patients with CSO tumors. MATERIAL AND METHODS: publications were searched and selected in bibliographic databases PubMed, Web of Science, Scopus. To study the approach to perioperative management of patients with CSF tumors, the works published from 2013 to 2023 were analyzed. Search keywords: pituitary surgery, anesthesia. Based on the analysis of current problems in anesthesia planning for patients with CSF tumors, the search was expanded with additional keywords: “pituitary tumor”, “perioperative complications”, “endocrine disorders”, “difficult airway”, “acromegaly”, “cardiologic complications, acromegaly”, “peripheral neuropathy, acromegaly”, “trigemino-cardiac reflex”, 206 publications were additionally analyzed and the main key points in anesthesia planning were summarized. A total of 230 publications were included but 161 were excluded. A total of 69 studies were selected. RESULTS: The main features of patients with CSF tumors are: water-electrolyte disorders, cardiovascular pathology, difficult airway. This determines a multidisciplinary approach in preparation for surgery. It is necessary to take into account these features when planning anesthetic support and management of the early postoperative period. In addition, endoscopic transnasal-transsphenoidal access may cause a number of complications: damage to the hypothalamic region and large vessels, and in the postoperative period: respiratory disorders, hormonal insufficiency, Water and Sodium Disturbances. CONCLUSIONS: Additional vigilance is required when preparing a patient with CSF formation for surgery. Perioperative management of a patient with CSO tumor requires a team approach with participation of neurosurgeons, neurologists, ophthalmologists, endocrinologists, cardiologists, anesthesiologists-resuscitators.
Predictors for negative clinical outcome in acute mesenteric ischemia after on-pump cardiac surgery: a retrospective observational trial
Authors: Ponomareva A. D. , Leyderman Ilya N. , Kasherininov I. Y. , Danilov I. N.
Published: April 2024

INTRODUCTION: Acute mesenteric ischemia (AMI) is one of the most dangerous complications of cardiac surgery using cardiopulmonary bypass (CPB). Several factors may contribute to the development of AMI, such as: age over 70 years, prolonged CBP, postoperative heart failure, cardiogenic shock, mechanical circulatory support and others. The mortality rate in AMI reaches 85 %. OBJECTIVE: To identify predictors of a negative clinical outcome in the development of acute mesenteric ischemia in patients after on-pump cardiac surgery. MATERIALS AND METHODS: A single-center retrospective observational cohort study included 53 patients in the intensive care unit who developed AMI after cardiac surgery performed using CPB. All patients with AMI included in the study were divided into two groups — survivors (n = 31) and non- survivors (n = 22) to identify predictors of negative clinical outcome. RESULTS: At the preoperative stage, the left ventricular ejection fraction (LVEF) was impaired in both groups, but in non-survived patients was significantly lower: 34.6 (25.4–52.4) in survivors and 28.7 (25.2–42.7) in non-survivors (p = 0.05). 12 hours after the surgery, the cardiac index (CI) (p = 0.01) and the index of left ventricular work (ILVW) were significantly (p = 0.03) lower in non-survivors. The average duration of CPB was 124 minutes (95–142) in survivors and 164 minutes in non-survivors (145–176) (p = 0.02). Also, 72.7 % of n0n-survivers received high doses of adrenomimetics in the postoperative period, in survivors — 41.9 % (p = 0.03). The rate of long-term mechanical respiratory support usage in non-survivors reached 86.3 %, in survivors — 35.4 % (p = 0.003). CONCLUSIONS: The key predictors of a negative outcome of OMI in cardiac surgery patients are: prolonged use of CBP, low CI, LVWI before and after surgery, high doses of adrenomimetics, prolonged mechanical respiratory support, as well as high concentrations of blood lactate 12 hours after the end of the surgery.
Predicting an unfavorable outcome in patients with liver failure associated with obstructive jaundice syndrome: a prospective observational study
Authors: Petrova Marina V. , Mamoshina I. V.
Published: April 2024

INTRODUCTION: Specialized scales developed to assess survival and mortality of patients after liver transplantation have not been validated when applied to liver failure in the setting of obstructive jaundice. OBJECTIVE: To determine the prognostic value of multiparametric scoring scales and to identify predictors of unfavorable outcome in liver failure due to obstructive jaundice. MATERIALS AND METHODS: 53 patients with confirmed liver failure due to obstructive jaundice of benign etiology who underwent biliary decompression were included in this prospective, observational, single-center study. Depending on the outcome two groups were distinguished: with favorable (n = 27, 51 %) and with unfavorable outcome (n = 26, 49 %). The following time points were defined for the dynamic evaluation of the course of the disease: day 1, day 3, day 7, and day 11 after decompression. Statistical processing of the data was performed using IBM SPSS Statistics 22 software for social science data analysis. RESULTS: The sensitivity and specificity of the studied scales in predicting liver failure due to obstructive jaundice were calculated on the basis of receiver operating characteristic (ROC) analysis. The AUROC for the SOFA was 0.862, for the MELD — 0.882, for the APACHE II — 0.864, for the Child-Turcotte-Pugh — 0.813. The sensitivity and specificity values for the SOFA were 78.9 and 77.8 %, for the MELD — 80.8 and 79.7 %, for the APACHE II — 57.7 and 81.9 %, and for the Child-Turcotte-Pugh — 75.1 and 70.9 %, respectively. Albumin was an independent predictor of unfavorable outcome (AUC ROC 0.909, p = 0.01), sensitivity 88.6 %, specificity 85.2 %. CONCLUSIONS: The scales presented in the study and the biomarker candidate “albumin” showed significant prognostic ability, but low values of sensitivity and specificity (less than 80 %) in some points of the study require the search for additional predictors of unfavorable outcome of liver failure due to obstructive jaundice.
Tactics of infusion therapy in patients with acute destructive pancreatitis: a narrative review
Authors: Protsenko D. N. , Tsvetkov Denis S. , Shifman E. М.
Published: April 2024

INTRODUCTION: Infusion therapy is the main method of correcting pathological changes that occur during the phase of “aseptic” inflammation in acute pancreatitis. OBJECTIVE: Summarize current data on infusion therapy regimens in patients with acute destructive pancreatitis, the advisability of using various infusion solutions and options for monitoring the effectiveness of therapy. MATERIALS AND METHODS: The study was carried out in accordance with international reporting requirements for reviews (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). The search was carried out in the following Internet search engines Pubmed and Cochrane Controlled Clinical Trials Register. To select articles, a literature reference search method was also used. The search strategy did not include restrictions on language, article type, or date. RESULTS: The analysis of literature data revealed two approaches to infusion therapy. The initial interest in “aggressive (4 liters per day or more)” infusion therapy regimens in the first 24 hours of the disease has now been replaced by a trend towards less “aggressive” regimens due to the publication of works on the high incidence of various complications (progression of organ dysfunction, local complications). When considering the qualitative composition of infusion therapy, preference should certainly be given to crystalloids. Basic monitoring of infusion therapy should include non-invasive methods: heart rate, blood pressure, diuresis rate. CONCLUSIONS: The analysis demonstrated different approaches to the tactics of infusion therapy in this category of patients. further research into the effectiveness and safety of infusion therapy, taking into account the varying severity of acute pancreatitis, the possibility of the influence of the qualitative composition of the infusion on the course of this disease and the formation of recommendations for initial and maintenance infusion therapy based on the principles of personalized medicine.
Chemical composition and biological activities of essential oils and extract of Eucalyptus citriodora Hook
Authors: Şahin Bihter , Cakır Cansel , Sıcak Yusuf , Öztürk Mehmet
Published: April 2024

In this study, the leaves of Eucalyptus citriodora Hook (Lemon-Scented Eucalyptus) were harvested and collected from Üzümlü neighborhood of Fethiye district of Muğla in 2021. Chemical content analysis of steam distillation and hydrodistillation of essential oils were determined by GC-MS, while phenolic content of methanol extract was determined by HPLC-DAD. Antioxidant activities of essential oils and methanol extracts were determined by DPPH radical removal, ABTS cation removal, β-carotene linoleic acid, and CUPRAC activity methods; Anticholinesterase activity against AChE and BChE enzymes was determined by Ellman method; and tyrosinase inhibition associated with melanin hyperpigmentation, α-amylase inhibition, and α-glucosidase inhibition activities associated with diabetes were determined as an in vitro. The bioactivities and chemical contents of E. citriodora species, a great value of, Türkiye, were determined, bringing new natural products to organic chemistry. As a result of the study, new bioactive extracts would be obtained and thus, they can effectively reveal the potential of new business opportunities. Since methanol extract is effective against incurable diseases such as Alzheimer's and diabetes, it will also be possible to develop therapeutics of such diseases by investigating the advanced chemistry and in vivo activities of the extracts with new projects.
Patchy Anthropocoasts: A transdisciplinary perspective on dunes, plants, rabbits, and humans in the United Kingdom
Authors: Vina Michael , Sampath D.M.R , Freitas Joana
Published: April 2024

In recent years, there has been increasing societal awareness of the crucial role that coastal dunes play in protecting against rising sea levels, mitigating climate change impacts, promoting biodiversity, and providing recreational opportunities. In some regions, dune management has been particularly focused on biodiversity and ecosystem restoration and the presence of alien species on dunes raises concerns about how these species become 'native,' 'invasive,' or 'hybrids' and whether they belong in their new ecosystems. These concerns illustrate how certain animals and plants assume different statuses according to normative categories associated with varying objectives. This article explores how perceptions of coastal dunes in the UK have transformed over time, from marginal resource frontiers to highly valued environments shaped by multispecies relations. In addition, this work explores how dunes around the UK emerge as ‘patchy anthropocoasts,’ that is, uneven landscapes designed by human purposes linked to economic activities, conservation, rabbit populations, unwanted vegetation, and the control of unpredictable sand movements. Bringing together diverse historical materials and scientific literature, this article links human and nonhuman histories with present debates on dune restoration from a transdisciplinary perspective rooted in anthropology, environmental history, and the natural sciences.
Taking Time to Know the Island: Multiple temporalities and changing mobilities on Dugi Otok, Croatia
Authors: Anica Anica , Oroz Tomislav
Published: April 2024

This article is based on the results of field research conducted on several occasions in 2020 and 2021 on the island of Dugi Otok, situated off the Dalmatian coast in Croatia. The article explores the notion of multiple temporalities emerging through the entanglement of spatial transformations, diverse forms of mobility and the lived experience of islanders. The concept of ‘multiple temporalities’ introduced in this article approaches these three aspects as heterogeneous temporal modalities that point to the coexistence and interplay of diverse, sometimes even opposing and contradictory, temporal rhythms. Inspired by theoretical and methodological approaches arising from the temporal turn while rethinking their potential in the context of Island Studies, the article focuses on the specific relations emerging from infrastructural development and the embodied experience of islanders. In order to grasp the complexities of what is popularly referred to as ‘island time’, the aim of the article is to show how processes of transportation development shape islanders' experiences of time.
The Prince of the Abrolhos, 2020–2023: On Micronations and Pseudolaw in Western Australia
Authors: Bicudo de Castro Vicente , Hobbs Harry
Published: April 2024

This article examines the Houtman Abrolhos Micro Nation, established by Kristin MacDonald, a Western Australian man, in 2020. The article draws on media reports and documents prepared by the ‘prince’ in support of his legal claims. Notwithstanding a curious attempt to draw support from the neighbouring micronation of New Westralia, MacDonald’s claims were quickly dismissed by the Geraldton Magistrates Court in 2023, and the micronation has ceased to operate. Nevertheless, its brief existence demonstrates the continuing allure of micronationalism and pseudolaw for some individuals who have allowed what they perceive to be a personal injustice to take on a political dimension.
Staging Posts: Thinking through the Orkney archipelago
Authors: Mclean Ross
Published: April 2024

The Orkney Archipelago, around 10 miles off the north coast of Scotland, has seen 6000 years of human settlement, with many archaeological artifacts offering significant insights into the formation of a deep-rooted island culture. The various transfigurations of this island culture to present-day Orkney indicate how external influences shape cultural inheritances, yet how this culture retains fundamental qualities; of imagination, resourcefulness, and territorial interconnections. This issue of how we negotiate the complexity of archipelagic relations is presented through a framework of process-based terms, of formations, transfigurations, constellations, aggregations, and tensions. This framework offers a degree of conceptual specificity, bringing focus to processes of relation change, movement, and interaction, across varying spatial and temporal scales. Underpinned by observational fieldwork, what emerges in this study is a sense of island life, bringing light to cultural and environmental processes, often most intensively manifest around strategic staging posts.
Imagining a Utopian Island: Reading Sarah Joseph’s Aathi (2011)
Authors: Jyothi James Anna , M Shalini
Published: April 2024

This article reads the novel Aathi (‘The gift in green’), written in 2011 by the Malayalam author Sarah Joseph, within the frameworks of Blue Humanities and Island Studies. Keralam's cultural geography is inherently entwined with its coastal and aquatic environment, necessitating an examination of this South Indian coastal state through a hydrological lens, especially in light of anthropogenic environmental instabilities. This study intends to analyse how the centrality of water in this text impacts its narrative and themes by positing the imaginary island of the text as a utopian aquapelago. As an early feminist writer in Kerala, Sarah Joseph incorporates ecofeminist sensibilities in the text, allowing for a re-exploration of discourses around women and the environment from an aquatic perspective. By examining Aathi as a South Asian literary work, this article also aims to deepen the understanding of the region's environmental, cultural, and social milieu, emphasising the need for multiple voices and perspectives in dealing with water-related issues.
Island Art Sustainability Education: A case study of Osakikamijima, Japan
Authors: Qu Meng , Zollet Simona , Chiya Amos
Published: April 2024

Although both arts education and community sustainability are very important topics for island communities, there is a dearth of academic research on the use of artistic activities to support sustainable island development. In this research, Osakikamijima, a depopulating Japanese island that the Japanese government is trying to rebrand as 'education island', was used as a case study on education on sustainability through the arts. The article employs participatory action research in the form of a 3-day art workshop collaboration between an international middle school, two universities and island residents. Students engaged in sustainability-focused deep mapping exercises, followed by the creation of artist’s books and island soundscapes, to explore how the Sustainable Development Goals (SDGs) relate to the island's challenges. The findings reveal that deep mapping enhances students' understanding of the island's interwoven sustainability issues, allowing them to creatively express local knowledge. Despite challenges, these arts-based educational activities foster students' creativity and divergent thinking. Furthermore, the use of an approach combining field studies and art education appears to be more impactful than traditional teaching methods, offering a practical example of how art can strengthen sustainability education on islands and contribute to their revitalisation.
Understanding Local Perceptions of Impacts of Climate Change Among Small-Scale Sama-Bajau Fishers and Their Patrons in Wakatobi National Park, Indonesia
Authors: Abu Samah Asnarulkhadi , Maruf Amar , Ahmad Nobaya , Hamsan Hanina
Published: April 2024

Understanding similarities and differences in perceptions of climate change impacts aids in the development of co-adaptation strategies. While there has been extensive research on perceptions of climate change impacts among small-scale fishing communities, studies focusing on the perspectives of maritime tribes, fishers, and their respective patrons in small islands are notably scarce. The current study compares the perceptions of climate change impacts by Sama-Bajau fishers and their patrons in Wangi-Wangi Island of Wakatobi National Park. Data was collected through in-depth interviews, casual conversations, field observation, and secondary data analysis between August 2021 and February 2022. Findings revealed that although fishers and their patrons similarly perceived some impacts, they perceived others differently because of distinct sources of information and experience. Fishers, middlemen and employees of fishing companies perceived the impacts through personal observation and information from other fishers while government and non- governmental officers relied on scientific reports and personal experience in addition to the information given by the fishers. Future research should explore context-specific coping, adaptation and transformation measures based on local perceptions and diverse patron-client relationships to inform policy development.
Yunus Emre Divanı’nda Tanrı Anlayışının Esmayıhüsna Bağlamında Çözümlenmesi
Authors: Bunsuz Halil
Published: April 2024

Anadolu topraklarının Moğol istilası, taht kavgaları ve halk isyanları ile siyasi, içtimai ve kültürel anlamda geçirdiği buhranlı zamanlarda yaşamış olan Yunus Emre, Anadolu insanına şiirlerinde ifade ettiği düşünceleri ile nefes aldırmıştır. Tarihî serüvenlerinde birçok sıkıntıyı aşan Türk milleti XIII. ve XIV. asırda karşılaştığı zorlukların üstesinden gelirken Yunus Emre’ye kulak vermiştir. Bu dönemde Yunus Emre, ümitsizliğe düşen Anadolu insanına ümit aşılamış; dostluğun, kardeşliğin öneminden bahsederek onları birlik ve beraberliğe davet etmiş; dünyanın geçiciliğini hatırlatarak, Kur’an-ı Kerim ve hadislerin yol göstericiliğinde yaşamayı öğütlemiştir. Şiirlerinde halkın sorunlarını ifade ettiği, halkı ve Hakk’ı sevdiği görülen Yunus Emre, insanlara Allah’ı tasavvufi bir pencereden anlatmaya ve sevdirmeye çalışmıştır. Bu yönüyle Hak âşığı, Allah dostu gibi sıfatlar ile anılan Yunus Emre’nin Cenab-ı Hakk’ı sadece sevgi odaklı anladığı ve anlattığı düşünülebilir. Oysa Dîvân dikkatle incelendiğinde onun, Tanrı’yı hesap soran, suçluları cezalandıran, nimet veren, tüm kâinatı idare eden, adil ve ilim sahibi olduğunu bildiği, kudreti, yüceliği, hidayet verici gibi farklı isim ve sıfatları ile tanıdığı ve insanlara anlattığı görülmektedir. Bu bağlamda Yunus Emre, Allah’ın doksan dokuz isminin terkibi olan esmayıhüsnadan önemli ölçüde faydalanmıştır. Makalede, yaşadığı çağı ve coğrafyayı aşarak sesini ve sözünü insanlığa duyurmaya devam eden Yunus Emre’nin, divanında Allah’ı nasıl anladığı ve insanlara anlatırken esmayıhüsna diye ifade edilen isimlerden ve manalarından ne kadar ve nasıl faydalandığı anlatılacaktır. Bu durum aynı zamanda Yunus Emre’nin ciddi bir İslami eğitim aldığını ileri sürenler için de yeni bir dayanak olacaktır.
Popüler Roman Odağında Kırgız Yazar Çolponbek Abıkeyev’in Brilliant Cılan Romanını Okumak
Authors: Şener Ayşe
Published: April 2024

Edebiyat, müzik, sinema, eğitim, sağlık gibi halkın ihtiyaç duyduğu pek çok alanda kendini gösteren popüler kültür, temelde halkın hızlı tüketimini ifade etmektedir. Popüler kültürün bir ögesi olan popüler edebiyat ise kanonik edebiyatın dışında kalan, insanı gündelik kaygılardan uzaklaştıran, insanın hoşça vakit geçirmesini sağlayan eserleri içermesiyle okur kitlesi ve satış oranı bakımından büyük çoğunluğu oluşturan bir alandır. Bu bakımdan popüler edebiyat kavramı kolayca tüketilebilir, çokça satılabilir ve bunlara bağlı olarak geniş kitlelere ulaşabilir eserleri ifade etmektedir. Kırgız edebiyatı başlangıcından itibaren Sovyet ideolojisinin etkisiyle politik bir çizgide ilerlemesi sebebiyle büyük ölçüde toplumsal meseleleri, siyasi temaları ele almıştır. Şüphesiz bağımsızlıkla birlikte bu ideolojik güdümün zayıflaması, popüler romana yaşam alanı yaratmıştır. Bağımsızlıkla birlikte bu alana yönelen önemli isimlerden biri Çolponbek Abıkeyev’dir. Bu makalede, Abıkeyev’in yayımlandığı yıldan bugüne kadar pek çok kez basılmış ve yüksek tirajlara ulaşmış Brilliant Cılan romanı, popüler roman odağında belirlenen kriterlere göre incelenmiştir. Neticede romanın adındaki sembolik anlam, dikkat çekici kapağı, dil ve üslubundaki sadelik, olayların fazlalığı ve hızlı biçimde gelişmesi, kişilerin çokluğu ve karakterizasyonun zayıflığı, klişelik, hacimli ve seri halinde yazılması, geleneksel anlatım tekniklerinin öne çıkması, anlatıcının taraflı tutumu, duygusallığı açığa çıkaran teması, yazarının popülist tavrı olmak üzere popüler romanlarla benzer özellikler taşıdığı belirlenmiştir.
MEDIA IMAGE OF RUSSIA IN KAZAKH TELEGRAM CHANNELS
Authors:   Astrakhan Tatishchev State University, Chernichkin Dmitry A. , Krivenko Anastasia I. ,   Astrakhan Tatishchev State University
Published: April 2024

The article is devoted to the assessment of the current media image of Russia in the telegram channels of the Republic of Kazakhstan. The data sources were information published in Kazakhstani telegram channels (posts and comments) from 2016 to 2023 and selected according to predetermined criteria. In total, during the specified period, 8333 posts and 35339 comments were recorded for the given markers, which were subjected to further analysis. The information content of Kazakh telegram channels is overwhelmingly devoted to the review of political events, law, as well as bilateral economic cooperation between Kazakhstan and Russia. Against the background of strong information pressure on Russia from the Western media, the coverage of the media image of Russia in the sphere of trade and economic cooperation by the Kazakh media is in line with traditional cooperation, interaction and good neighborliness. However, starting from 2020, the negative information agenda in Kazakhstani telegram channels has been demonstrating a steady growth. In particular, the largest increase in negative materials was recorded in 2022 as a reaction to 2 major events: the January spontaneous protests in the Republic of Kazakhstan (the entry of the CSTO troops into the country by the Russian leadership) and a special military operation on the territory of Ukraine (and, accordingly, the migration of some citizens Russia to the territory of Kazakhstan). Moreover, the negative attitude is directed not to the Russians, as to the civic identity living in this territory, but to the ethnic Russians, as responsible for the current foreign policy events. The growth of a negative assessment of Russia in the Kazakhstani online space may also negatively affect the change in the trend in the perception of Russia among the Kazakhstani population from “Own”, towards “Other”, or even “Enemy”. A gradual change in foreign policy guidelines (growth of trade relations with China, rapprochement with the US and the UK) will only accelerate this trend.
FORMS OF GOVERNMENT AND ETHNIC CONFLICTS: THE PROBLEM OF INTERCONNECTION AND ITS SOLUTION IN POLITICAL SCIENCE
Authors:   Kazan Federal University, Zaznaev Oleg I.
Published: April 2024

Prevention and ethnic conflicts resolution is an urgent task both at the level of theory and political practice. To solve it, institutional measures are used, including the design of a form of government. The purpose of the article is to determine the state of study of the problem of the relationship between forms of government and ethnic conflicts, mainly in contemporary foreign political science. The author proceeds from the idea that the form of government as an institutional structure affects the emergence, flow, and termination of ethnic conflicts, but at the same time it should be considered as one of the variables along with the electoral system and form of government. The article notes the contradictory nature of the theoretical positions of supporters of different approaches - consociationalism centripetalism and power-dividing approach. The most common point of view that a parliamentary system is more suitable for a multi-ethnic society is criticized. The author emphasizes the importance of conscious design of forms of government, aimed at abandoning the "pure" presidential and parliamentary systems and the creation of atypical institutions, which are given some attention in the article. Empirical studies using statistical methods have been carried out in recent years to identify the relationship between forms of government and ethnic conflicts. The author evaluates them and introduces the reader to the results of his own research using correlation and regression analysis. He concludes that the hypothesis about the influence of the form of government on ethnic conflicts requires further empirical testing on a large array of cases over a long period of time. At the end of the article, an analysis is given of the main methodological problems that researchers face when conducting a comparative study of ethnic conflicts and their relationship with political institutions. The author concludes that the problem of the relationship between forms of government and ethnic conflicts has not yet been resolved in political science.
DEMOGRAPHIC “CATASTROPHE” OF THE RUSSIAN FINNO-UGRIC PEOPLES: SOCIAL AND POLITICAL MOTIVATION FOR THE DRIFT OF IDENTITIES
Authors:   Institute of Language, Literature and History FRC Komi Sciencе Center of the Ural Division of the Russian Academy of Sciences, Shabaev Yuri P.
Published: April 2024

The results of the 2021 population census showed a sharp and significant decrease in the number of Finno-Ugric peoples in Russia. For example, the number of Karelians decreased by 46.7%, Komi-Permyaks - by 41%, Mordovians - by 35% (in 1939, the number of Mordovians was 1375 thousand people, in 2021 -484 thousand). Between the 2002 and 2010 censuses there was also a large-scale decline in the number of Finno-Ugric peoples, which allowed some local ethnic activists to talk about a “demographic catastrophe”, “extinction of peoples”. The idea of “extinction” began to be actively exploited at the turn of the 1980s and 1990s. and became the basis for the formation of ethno-national movements, the programs of which were built on the concept of "the revival of peoples". In Komi, the "Committee for the Revival of the Komi People" was created, in Mordovia, the society "Velmena" ("Revival") arose. The leaders of ethnic and ethno-political organizations strove to act not only as culturetragers, but also as moral censors not only for their own ethnic groups, but also for regional communities as a whole. But their mission failed, because ethnic entrepreneurs not only failed to become leaders of public opinion in the regions inhabited by the Finno-Ugric peoples, but turned out to be incapable of developing effective programs for ethno-cultural development, which was shown by the results of the census. In addition, the census showed that the transformation of the Finno-Ugric ethnic groups from agrarian to urban ethnic groups leads to an obvious strengthening of the processes of individual integration into the host urban communities, in which the Russians are the dominant group, and the Russian language dominates in all spheres of communication.
Video velocity measurement: A two-stage flow velocity prediction method based on deep learning
Authors: Wang Xiaolong , Ma Qiang , Wang Genyi , An Guocheng
Published: April 2024

Due to the uncertainty in output caused by environmental changes, significant discrepancies are expected between the surface flow velocities predicted using deep learning methods and the instantaneous flow velocities. In this paper, a two-stage deep learning flow velocity measurement algorithm is proposed. During the external calibration process, the upper and lower frames of the recorded water flow video are cyclically traversed to acquire predicted flow velocity values using the deep learning velocity measurement algorithm. Meanwhile, the pixel displacement is obtained using the sparse optical flow tracking method and then post-processed to derive the velocity calibration value and pixel calibration value. During the detection process, the deep learning-predicted flow velocity is internally calibrated using the velocity calibration value and the pixel calibration value to adapt to changes in water flows. Compared with the pre-improved algorithm, the method achieves the minimum root mean square error in five different flow velocity videos and maintains high accuracy when the flow velocity changes rapidly. The obtained results are very promising and can help improve the reliability of video flow rate assessment algorithms.
Impact of the comprehensive remediation project on hydrological conditions in the lower reaches of the Ganjiang River
Authors: Lu Jiangang , Fu Yanmei , Li Xuefei , Zhou Yuan , Zhang Liwei
Published: April 2024

This study undertakes a systematic analysis of the hydrological changes before and after the implementation of the Comprehensive Remediation Project in the lower reaches of the Ganjiang River. It focuses on changes in downstream inflow, ratios of flow distribution, and water levels, as well as water velocity near the gates. The results indicate a significant improvement in the spatial distribution of water resources in the lower reaches of the Ganjiang River. The project enhances the inflow from the northern and southern branches, positively influencing downstream water usage and the ecological environment. Building upon these findings, the study proposes operational recommendations tailored to different hydrological years, such as timely adjustments to the southern branch's water inflow and optimizing flow distribution ratios. This research provides a scientific basis for the implementation and dispatch of comprehensive remediation projects and offers insights into water resource management in similar regions.
Molecular Pathways and Treatment Updates on Huntington’s Disease with
Special Preference to Juvenile Phase: A Comprehensive Review
Authors: Suryavanshi Kunal , Sharma Anuj Kumar , Murti Yogesh , Kumari Vibha , Shanker Shukla Karuna , Kulshreshtha Mayank
Published: April 2024

A degenerative brain ailment called Huntington's disease (HTD) causes irritable behavior, emotional distress, cognition, etc. It is also known as
Huntington's chorea. Compared to men, women are more likely to get HTD. However, in India, if 3 to 5% of Europeans are affected, it is difficult
to estimate the disease's prevalence. The full pathophysiological status, several molecular pathways, and pharmaceutical and non-pharmacological
treatments for Huntington's disease are covered in this article. Google, PubMed, Scopus, Bentham, Elsevier, and other significant web resources
were used to gather the scientific data. Moreover, this review article may serve as the foundation for future study, particularly on Huntington's
illness.
Exploring Phytotherapy's Preventive and Therapeutic Impact on Global
COVID-19 Management: A Narrative Review
Authors: Parchami Ghazaee Sepideh , Sereda Petro , Marchenko-Tolsta Kateryna , Hameed Murtaza
Published: April 2024

Introduction::

The WHO Emergency Committee advocates preventive strategies for COVID-19 management, emphasising vaccines as highly effective but
acknowledging their limitations. Chloroquine and hydroxychloroquine, initially effective against COVID-19, were discontinued due to severe side
effects. Further clinical trials are imperative to establish the safety and efficacy of new antiviral agents, some of which may have harmful effects on
human development.

Objectives::

The shortcomings of various conventional treatments have prompted urgent efforts to discover safe, natural compounds that may be useful in
combating COVID-19. This study aims to review research that has investigated the potential of traditional phytotherapies used by different
populations for the prevention and symptomatic treatment of COVID-19 infection.

Methods::

This paper reviewed scientific studies published through searching on search engines such as PubMed, Scopus, Google Scholar, ScienceDirect and
Elsevier from May until October 2023.

Results::

The preventive and anti-COVID-19 attributes of Traditional Chinese Medicine, Ayurvedic formulations and African medicinal plants have been
substantiated in research. In Nepal, recommendations endorse the utilisation of medicinal plants for herbal teas and homemade sanitizers. Zingiber
officinale, Curcuma longa L. and Curcuma xanthorriza Roxb., along with Camellia sinensis are crucial Indonesian medicinal plants with potential
for treating COVID-19. Z. officinale was predominantly chosen for relieving coughs and sore throats associated with COVID-19 in Saudi Arabia.

Discussion::

The immunomodulatory properties of medicinal plants, which may prove useful in combating COVID-19, have been verified via elevation of the
level of peripheral WBCs, IgM, IgG; inhibition of leukotrienes and prostaglandins, maintenance of the integrity of intestinal mucosal barrier and
regulation of HMGB1. The antiviral effects of herbs, including the inhibition of viral DNA and RNA replication, down-regulation of oxidative
stress, and the impediment of SARS-CoV-2 access to vascular endothelial cells, suggest their potential to facilitate earlier recovery from
COVID-19 infection.

Conclusion::

Advancing scientific research in phytotherapy promises the possibility of novel approaches for effectively managing future infectious diseases and
pandemics.
Impact of Combination Therapy with Chemical Drugs and Megavoltage X-ray
Exposure on Breast Cancer Stem Cells’ Viability and Proliferation of MCF-7
and MDA-MB-231 Cell Lines
Authors: Banisharif Dehkordi Fatemeh , Ghatrehsamani Mahdi , Abdolvand Maryam , Soltani Amin , Masoumi Seyed Hossein
Published: April 2024

Background::

Breast Cancer (BC) is a serious malignancy among women. However, chemotherapy
is an important tool for cancer treatments, but the long-term use of chemotherapy drugs may lead to drug resistance
and tumor recurrence. Since Breast Cancer Stem Cells (BCSCs) can be the main factor to induce BC
treatment resistance and recurrence, investigation of BCSCs signaling pathways can be an effective modality
to enhance cancer treatment efficiency.

Objective::

In this study, the effect of metformin, SB203580, and takinib alone or in combination with radiotherapy
on MCF-7 and MDA-MB-231 breast cancer cell lines was evaluated.

Methods::

MCF-7 and MDA-MB-231 breast cancer cell lines were treated with metformin, SB203580, and
takinib for 24 or 48 hours, followed by X-ray exposure. The MTT assay and flow cytometry analysis were performed
to assess cell growth inhibition and cellular death, CXCr4 expression, and BCSCs, respectively.

Results::

The results showed the combination of takinib/SB203580 with radiotherapy to remarkably reduce the
CXCR4 expression and BCSCs levels in the MCF-7 cell line. Also, the concurrent administration of
takinib/metformin/radiotherapy significantly reduced BCSCs and CXCR4 metastatic markers in the MDA-MB-
231 cells. Since the MAPK signaling pathway has an important role in inducing drug resistance and cell proliferation,
the use of SB203580 as an inhibitor of p38 MAPK can improve breast cancer treatment. Furthermore,
metformin and ionizing radiation by suppression of the mTOR signaling pathway can control AMPK activation
and cellular proliferation.

Conclusion::

Anti-cancer and cytotoxic effects of metformin can be effective in this strategy. In conclusion,
the combination of conventional chemotherapeutic drugs, including SB203580, metformin, and takinib with
X-ray exposure can be a new approach to diminish the drug resistance of breast cancer.