bluuebunny/crossref_metadata_2025 huggingface dataset:
WhatsApp as a strategy to socialise funeral products during the Covid-19 pandemic
Authors: Prihatiningsih Witanti , Maliki Musa , Ayuningtyas Fitria , Intyaswati Drina , Maella Nurannafi Farni Syam
Published: December 2022

The Covid-19 pandemic has forced many people to stay at home. People in Indonesia are encouraged to work from home (WFH) from 2020 until 2022. The WFH has significantly impacted the economy, especially among field workers. The MA cannot promote its product and services during this time. Therefore, the sales are decreasing. This study describes how the MA uses WhatsApp to socialise their product and services to seek potential customers amid the pandemic. This research involved descriptive qualitative methods, with five MAs as respondents. This study showed that the MAs maximised WhatsApp in socialising funeral products to customers during the pandemic. MAs used WhatsApp features such as "Profile Picture" and "Status" to attract people by keeping their contact numbers. The funeral product details were later socialised in texts, photos, and videos funeral prices will never be mentioned by the MA unless potential customers are asking about it.
Psychosocial Support for Orphaned and Vulnerable Children with HIV/AIDS in Eastern Cape, South Africa
Authors: Mufalali Ruth M. , Makua Memme Girly , Matlhaba Kholofelo L.
Published: December 2022

South Africa has an estimated 2.5 million children aged from birth to 14 years who have lost one or both of their parents due to the Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS). There is a scarcity in the psychosocial support aspect of improving orphaned and vulnerable children’s (OVC) adherence and retention of HIV/AIDS treatment. This study explores and describes the achievements of the SARCS community intervention that the South Africa Red Cross Society (SARCS) undertook in providing psychosocial support to OVC infected with HIV/AIDS in Maluti sub-village in the Matatiele Local Municipality, in Alfred Nzo District, Eastern Cape, South Africa. A descriptive qualitative design of appreciative inquiry was conducted to assess OVC’s perceptions regarding the effectiveness of the SARCS community intervention. Data collection was done using the World Café method, which makes use of an informal café setting where participants can explore an issue by discussing it while seated in small groups around tables. Thirty OVC between the ages of 13 and 17 years were purposively sampled and moved between tables at fixed time intervals, and in small groups discussed the questions that were channelled through an interview guide. The study established that OVC can thrive when their psychosocial basic needs are met. The SARCS Maluti project was instrumental in forming synergies in the cultivation of support systems between the OVC and the communities in which they reside when addressing psychological and socio-economic issues and HIV/AIDS. The study made recommendations that emphasised the importance of applying a holistic approach and the positive aspects of the inclusion of activities in addressing the OVC’s needs and their psychological adaptation.
DIGITALIZATION OF THE SCIENTIFIC LIBRARY OF THE OMSK STATE TECHNICAL UNIVERSITY
Authors:   Omsk State Technical University, Meizhaitis S. A. , Tsukanov T. S. ,   Omsk State Technical University
Published: December 2022

The article describes the process of digitalisation of the scientific library of the Omsk State Technical University by creating a new information system. Online services that the library will provide to users, and innovations, such as an electronic library card, are proposed and described. A functional layout is presented and the design of the information system is described. The results of digitalisation and their impact on the interaction of the library with the user are analysed.
PROBLEMS OF FORMING INFORMATION COMPETENCE IN LIBRARIES OF HIGHER EDUCATIONAL INSTITUTIONS: ON THE RESEARCH MATERIALS
Authors:   Omsk State Technical University, Mikhailenko V. S. , Medvedeva E. V. ,   Tomsk State University, Petrova M. A. ,   Tomsk State University, Shubert V. I. ,   Tomsk State University
Published: December 2022

The article is devoted to the results and conclusions of the first stage of the All-Russian study "Formation of information competence of students in the digital environment" (June-July 2021). The task of this stage is to study the state of affairs in the formation of information competencies of students in several areas: content, forms, features, problems. At the stage of questionnaire analysis, five technologies and trends were formed that can influence the formation of information competencies. Based on the results of the study, a modular exemplary program was formed, which elements can be used in the preparation of curricula and programs in libraries.
Extensive tension pneumocephalus presented in the setting of a challenging etiology
Authors: Salih Hayder R. , Jaafer Huda , Ismail Mustafa , Khallaf Ali Kareem , Mohammed Ali Jassim , Al-Mosawy Mohammad Sadeq M. J. , Naser Hawraa Sadiq , Maulood Ziyad Talal , Hafedh Anwar N. , Hoz Samer S.
Published: December 2022

Background:

Pneumocephalus (PNC) is a well-described consequence in postoperative settings and skull fractures that is usually self-limiting. It can get complicated into tension PNC on some rare occasions, leading to an intracranial mass effect. PNC was also reported after unintentional dural puncture throughout the epidural anesthesia process. However, tension PNC resulting from epidural anesthesia procedures is an extremely rare outcome that implies urgent intervention to relieve the tension within the brain. Here, we report a case of an extensive tension intraventricular PNC 2 days following an epidural anesthesia procedure for a femur fixation surgery.

Case Description:

A 23-year-old male presented to the emergency department with basal skull fractures and a femur fracture due to a motorcycle accident. His skull base fracture was managed conservatively then he underwent a femur fixation procedure under epidural anesthesia. Two days after, he developed a severe headache with a disturbed level of consciousness. Computed tomography of the brain revealed an extensive PNC that involved all the subarachnoid spaces down to the cervical region and compressing the cerebellum, which was not found in the initial imaging. The patient’s status improved after the twist-drill burr-hole evacuation of air under the water seal.

Conclusion:

Extensive tension PNC can occur after traumatic brain injury, especially after epidural anesthesia. Such cases should gain high focus because they may differ from simple PNC regarding diagnosis, treatment, and follow-up.
PROBLEMS AND PROSPECTS OF SMALL BUSINESS ENTERPRISES INVESTMENT ACTIVITIES MANAGEMENT
Authors: Kondratenko Nataliia , Zaporozhets Hanna , Dogadina Valentina
Published: December 2022

The article defines the problems and prospects of managing the investment activities of small business enterprises. It was established that a small business as an object of management is a very complex, dynamic, socio-economic, production, organizational and technical system that is open to the influence of the external environment. It was noted that today the investment activity of an enterprise or organization is possible under the condition of innovative development and the spread of innovative processes within the framework of an individual enterprise. The formation of the innovations investment support system for the organization is a set of actions to ensure all types of innovations and innovation processes carried out at the enterprise. The basic principles of small business enterprises are defined. It is noted that the management of investment activities of small business enterprises in Ukraine is a rather complex process, as all business entities are forced to overcome a large number of macroeconomic obstacles, the main reason of which is ineffective financial policy, excessive tax pressure and other restrictions established at the legislative level. Thus, today there is an urgent need to improve the management of investment activities of small business enterprises, as an important factor in the sustainable growth of the country's economy, which provides the basis for the formation and expansion of the economic potential of the national economy of Ukraine. The conducted research made it possible to generalize the problems and determine the prospects of managing the investment activities of small enterprises.It was concluded that, taking into account the unprofitability of the majority of small business enterprises in the conditions of martial law and financial crisis, it is expedient to create and ensure a favorable investment climate, the development of innovation and investment activities, which will certainly contribute to the positive dynamics of socio-economic development and the possibility of modernization of the national economy.
Biochar for Shape Stabilized Phase-Change Materials
Authors: Sparavigna Amelia Carolina
Published: December 2022

Biochar is the black residue remaining after the pyrolysis of biomass. It has a pore structure with large specific surface area, accompanied by a strong adsorption capacity. Due to its mesoporous framework, biochar can be used to shape stabilize the phase-change materials (PCMs). A PCM is a substance absorbing and releasing thermal energy at a phase transition. Therefore, biochar and PCMs are producing composites which can be useful for heating and cooling applications. Here we propose a discussion of recent literature about development and applications of biochar-based composite PCMs. In particular, the literature about the role of biochar mesopores in the encapsulation of PCM is highlighted.
Development of Adagrasib’s Commercial Manufacturing Route
Authors: Snead David , Gan Yonghong , Scattolin Thomas , Paymode Dinesh , Achmatowicz Michal , Rudisill Duane , Vidal Ephraim , Gharbaoui Tawfik , Roberts Phil , Yang Jianbo , Shi Zhangbing , Liu Wei , Bolger Joshua , Qiao Zhen , Chen Cheng-yi
Published: December 2022

A commercial route to MRTX849 (adagrasib) was developed to support clinical and commercial needs. Yield was improved to 32% over six chemical steps. A doubly regioselective SNAr reduced consumption of an expensive chiral intermediate, reaction optimization led to parts per million palladium catalysis, and a new method to deprotect Cbz-groups were developed to mitigate risk associated with benzyl iodide.
Targeting Nitrogenated Aromatics: Tandem Diels-Alder/Aromatization Reaction of Chitin-Derived Furans
Authors: Santos Camila , Mattioli Renan , Baptista Júlia , Da Silva Vitor , Pastre Julio
Published: December 2022

The application of biomass-derived furans in sequential Diels-Alder (DA)/aromatization reactions is a promising approach for the preparation of aromatic compounds with different substitution patterns. In this work, we addressed the challenge of using chitin-derived furans, 3-acetamido-5-ethylfuran (3A5EF) and 3-Acetamido-5-(1-hydroxyethyl) furan (3A5HF), for the formation of 4-Acetylaminophthalimides and other N-containing aromatic compounds. The transformation is carried out sequentially and involves the formation of the DA adduct, 7-oxa-norbornene, which in an acid/acetylating medium undergoes a dehydration/aromatization reaction, providing the compounds in yields ranging from 16-80%. To the best of our knowledge, this is the first report involving a chitin derivative for the formation of 4-Acetylaminophthalimides, which is the first step towards expanding the toolbox of chitin-derived furans in the synthesis of nitrogenated aromatic compounds with the nitrogen atom directly attached to the benzene ring.
Enhancing Ru-Catalyzed Guerbet Reactivity for Biofuel Production from Ethanol
Authors: Davies Alex M. , Farris Benjamin M. , Stephenson Corey R. J. , Szymczak Nathaniel K.
Published: December 2022

We recently reported the development of an N,N,N-pincer Ru catalyst ClRu(5-Mebpi)(PPh3)2 (bpi = 1,3-bis(2′-pyridylimino)isoindolate) for the efficient production of advanced biofuels from ethanol via the Guerbet reaction. This catalyst provided 65 % yield and C4-C8 alcohols and the current highest TON (155,890) and TOF (12,690 h-1) reported for a homogenous, single-site Guerbet catalyst. Through mechanism guided catalyst re-design, we have further enhanced the reactivity of these catalysts via selective ligand modifications, leading to the development of two new catalysts. ClRu(5-OMebpi)(PPh3)2 and ClRu(5-tBubpi)(PPh3)2 provide 74 % and 76 % yields of higher order alcohols respectively - both representing the best-in-class homogenous catalysts for conducting Guerbet chemistry to date.
CarbonAI, A Non-Docking Deep learning based small molecule virtual screening platform
Authors: Wu Junfeng , Jin Kevin , Jiao Yang , Wang Xiaojie , Li Siwei , Pan Lurong
Published: December 2022

Structure-based virtual screening is a promising in silico technique that integrates computational methods into drug discovery. The most extensively used method in structure-based virtual screening is molecular docking. However, the docking process is not computationally efficient and simultaneously accurate due to classic mechanics-based scoring functions. These can only approximate, but not reach, quantum mechanics precision. In order to reduce the computational cost of the protein-ligand scoring process and use data-driven approaches to boost the scoring function accuracy, deep learning non-docking methods can be used by utilizing 3D structure or 1D sequence information of the protein target. This method can minimize the error inherited from molecular docking methods and avoid the extensive computational cost of docking. Furthermore, these two methods are integrated into an easy-to-use framework, CarbonAI, that provides both choices for researchers. Graph neural network (GNN) is employed in the 3D version and BiLSTM has been adopted in the sequence version of CarbonAI, respectively. To verify our approaches, different experiments were performed on two datasets, an open dataset Directory of Useful Decoys: Enhanced (DUD.E) and an in-house proprietary dataset without computer generated artificial decoys (NoDecoy). On DUD.E we achieved a state-of-the-art AUC of 0.981 and on NoDecoy we achieved an AUC of 0.974 whereas on the conventional docking program, the respective AUC performance is less than 0.8. The CarbonAI engine also reaches a state-of-the-art enrichment factor at top 2 percent for 36.2 folds. We have also retrospectively validated the CarbonAI models with various wet lab experimental data, and the results demonstrated a consistently accurate performance. Furthermore, the inference speed of the engine was benchmarked using the openly available 2021 Enamine REAL Database (RDB), that comprises over 1.36 billion molecules in 4050 core-hours using our CarbonAI non-docking method (CarbonAI-ND). The inference speed of CarbonAI-ND is about 36000 molecule per core-hour, compared to typical docking methods' speed of 20, which is about 16000 times faster than conventional docking method. Overall, the experiments indicate that CarbonAI is accurate and computationally efficient with good generalization to different molecular targets for virtual screening.
Molecular Modelling of Ionic Liquids: Perfluorinated Anionic Species with Enlarged Halogen Substitutions
Authors: Sun Zhaoxi , Zheng Lei , Zhang Zuo-yuan , Cong Yalong , Yang Jingjing , Wang Xiaohui
Published: December 2022

Ionic liquids as promising green solvents are widely applied in laboratory and industrial applications. Despite the massive experimental efforts on various applications, accurate computational modelling of such complex solution remains challenging. Our previous extensive numerical experiences on bulk properties, solvation and partition of external drug-like molecules between water and ionic-liquids phases lead to the recommended modelling regime of 0.8-scaled RESP charges and the GAFF2 parameter set. Such a protocol has been found to be effective in reproducing the experimental thermodynamic properties that require balanced descriptions of solute-solvent and solvent-solvent interactions. A deficiency in the previous benchmark set is the lack of voluminous and highly halogen-substituted anions. Therefore, in this work, we explore the calculation of ionic liquids involving large voluminous perfluorinated anionic species. Also, the ESP analysis confirms the similarity of the ESP produced by the gas-phase HF/6-31G* generated atomic charges and the higher-level implicit-solvent calculations. The quality of the HF/6-31G*-targeted charges is further validated by a direct face-to-face comparison of the bulk density estimated from molecular simulation under different charge sets, consolidating the protocol for model construction.
Accounting for Solvation Correlation Effects on the Thermodynamics of Water Networks in Protein Cavities
Authors: Barros Emilia P. , Ries Benjamin , Champion Candide , Rieder Salomé R. , Riniker Sereina
Published: December 2022

Macromolecular recognition and ligand binding are at the core of biological function and drug discovery efforts. Water molecules play a significant role in mediating the protein-ligand interaction, acting as more than just the surrounding medium by affecting the thermodynamics and thus the outcome of the binding process. As individual water contributions are impossible to be measured experimentally, a range of computational methods have emerged to identify hydration sites in protein pockets and characterize their energetic contributions for drug discovery applications. Even though several methods model solvation effects explicitly, they focus on determining the stability of specific water sites and neglect solvation correlation effects upon replacement of clusters of water molecules, which typically happens in hit-to-lead optimization. In this work, we rigorously determine the conjoint effects of replacing all combinations of water molecules in protein binding pockets through the use of the RE-EDS multistate free-energy method, which combines Hamiltonian replica exchange (RE) and enveloping distribution sampling (EDS). Applications on BPTI and four proteins of the bromodomain family illustrate the extent of solvation correlation effects on water thermodynamics and their influence on ligand binding and selectivity.
A CLINICAL STUDY OF COMPLICATED INGUINAL HERNIAS
Authors: S Kappikeri V , J Mise Sangamesh
Published: December 2022

Background and objectives Hernia is a common simple and easily treatable condition yet if ignored can lead to life- threatening complications. Lack of health awareness poverty and paucity of surgical facilities result in neglecting the condition for a long period of time. The patient ultimately approaches the emergency department with devastating complications. This study aims at illustrating the various modes of presentation management and post-operative outcome in complicated inguinal hernias.Methods The material for this study was collected from the patients of complicated inguinal hernia admitted in the Surgical Department of Basaveshwar Teaching and General Hospital attached to M.R. Medical College Kalaburagi from September 2015 to August 2017.Results In this study 50 cases of complicated inguinal hernia were studied. Among them 12 cases 24 presented within 24 hours of onset of symptoms while 38 cases 76 after 24 hours. Only 1case was female. 32 cases 64 were right sided and 16 cases 32 were left sided hernias. 2 cases 4 were bilateral hernias but had complication on only one side right side in both the cases. 44 of cases were irreducible 36 were obstructed and 20 were strangulated. 96 cases were indirect while only 4 were direct hernia. 82 cases were from rural and 18 cases th th from urban areas. Most common age of presentation was 4 and 5 decade. Most common mode of presentation was an irreducible swelling 100 followed by pain in 48 and vomiting in 46 cases. Small bowel was the most common content of the sac seen in 54 cases followed by omentum in 18 cases and small bowel with omentum in 16 cases. Most common surgery performed was herniorrhaphy in 74 cases followed by hernioplasty in 14 .There were 6 cases of strangulated hernia with non-viable bowel which underwent resection and anastomosis. There were 3deaths 6 all of them were late presented cases.Conclusion Patients who presented within 24 hours of onset of symptoms had mild clinical presentation shorter hospital stay lesser complications and no mortality. Whereas late presented cases gt24hrs had a more severe presentation prolonged hospital stay higher rate of complications and mortality. Most of the complicated cases were right sided and indirect inguinal hernias and in male patients. Patients from rural areas were found to have higher number of complicated cases than urban areas.
PENGARUH POTENSI AKADEMIK, EFIKASI DIRI DAN KEMANDIRIAN BELAJAR TERHADAP HASIL BELAJAR MATEMATIKA
Authors: Ernawati Ernawati , Ilhamuddin Ilhamuddin
Published: December 2022

This type of research was ex-post facto research. The population in this study were all students of class XI of SMK Negeri 2 Makassar while the sample in this study were XI TKJ 1 and XI TKJ 2, totaling 65 students. The sampling technique used cluster random sampling. Data analysis techniques using questionnaires and tests. Data analysis techniques used descriptive statiscal analysis and inferential statistic analysis techniques. The results of this study indicate that (1) Partially, the academic potential variable significantly influences the learning outcomes of students of class XI SMK Negeri 2 Makassar of 17.6%. (2) Partially self-efficacy variables significantly influence the mathematics learning outcomes of class XI students of SMK Negeri 2 Makassar by 43.4%. (3) Partially the learning independence variable has a significant effect on the learning outcomes of Grade XI students of SMK Negeri 2 Makassar by 78.8%. (4) Simultaneously the variables of academic potential, self-efficacy and learning independence significantly influence the learning outcomes of students of class XI in SMK Negeri 2 Makassar with a coefficient of determination R2 = 0.817 which means that the academic potential, self-efficacy and learning independence gave an effect of 81.7% on the mathematics learning outcomes of students of class XI of SMK Negeri 2 Makassar and the remaining 18.3% is influenced by other factors
PENGGUNAAN MODEL GARIS BILANGAN VERTIKAL OLEH SISWA DALAM MENYELESAIKAN MASALAH KONTEKSTUAL
Authors: Samuntya Fitri , Ikram Fadhil Zil
Published: December 2022

Many teachers in Indonesia teach students horizontal number lines rather than vertical number lines. However, there are students who use vertical number lines to solve contextual problems that have never been taught in schools. Therefore, this study aims to find out why students use vertical number lines to solve contextual problems. This research is a qualitative research where data is collected by tests and interviews. The results showed that students used vertical number lines based on the context of the given questions.
Study of the Photographer as a Study: Looking Inside Duncan Winder's Home (sometime between c1962 and 1965)
Authors: Wood Peter
Published: December 2022

In recent years there has been a small increase in research addressing the architectural photography of Duncan Winder. While this scholarship adds to critical appreciation of his skill and productivity as a recorder of New Zealand buildings, of his personal life we remain largely ignorant. To know an artist's life well does not guarantee a transparent view into their creative mind, but in the case of Winder we are so bereft of insight into his private life that the only way we have to explore him biographically is through his photographs. Overwhelmingly, Winder's archived oeuvre demonstrates a photographer determined to keep his own image firmly behind the lens. Foreground shadows and, on occasion, a blurred reflection, signal rare glimpses of the photographer at work. But otherwise, his common technique of bringing a hidden character to the camera suggests a determined effort by Winder to not only remain outside the view of the lens, but apart from the entirety of the scene being recorded. Against this pattern, this paper identifies seven images drawn from the Winder archive that present as being of a common domestic interior dated to the 1960s. Contrary to the proliferation of architect-designed rooms that dominate Winder's archive, these photographs show a modest home whose domestic character might be best categorised as "bach-like." Added to this, the composition of each photograph is unusually casual for Winder's work, and they read more as impulsive snap-shots than considered views. When content details are correlated against archival information it can be faithfully concluded that this interior is the home of Duncan Winder. The remainder of the paper interprets one of these images – "House interior, study" - as a knowing self-portrait by the photographer, and the visual scene is interrogated for evidence of Winder's inner world.
Part of the Landscape
Authors: Treep Lucy
Published: December 2022

In 1969, Lincoln College (later University) opened a two-year postgraduate course in Landscape Architecture, the first of its kind in New Zealand. It was described as "for those who seek employment as professional landscape designers in private consulting practice or as members of planning teams in departments concerned with major engineering projects, highways, forestry, conservation and large-scale agricultural development." The college was seen to actively encourage women into the profession and from the first days of the course at Lincoln, women were part of the landscape. On March 3, 1969, Emily Mulligan was one of five founder students attending the first lecture of this new course. After Mulligan graduated in 1971, she was joined, in 1974, by Di Lucas, Diane Menzies and Esmae Sage, and not long after then, women started to regularly fill about half of each Landscape Architecture class. In comparison, the first woman student at the Auckland College School of Architecture, Laura Cassels-Browne, enrolled in 1926, nine years after the establishment of the school. The first woman graduate of the School of Architecture was Merle Greenwood in 1933, 16 years after the school's establishment. Even in the 1960s and 70s women architecture students (who still made up small numbers) reported feeling uncertain of their welcome into the profession. Drawing on conversation with Emily Mulligan (now Williams), this paper will explore the nature of the landscape course at Lincoln, in what ways women students were encouraged in its early days, and the relationship of the course with the wider profession.
Gardening the interior: Odo Strewe inside the 1980s
Authors: Francis Kerry
Published: December 2022

Odo Strewe arrived in New Zealand in 1938, a refugee from Nazi Germany. After release from internment on Matiu (Somes Island) as an Enemy Alien during World War Two, he married and moved to Auckland where he started a landscape design and construction business. Strewe had explored the idea of plants inside buildings in the very first house that he had made for his family in Glen Eden, Auckland in 1949. An Australian journalist writing about the house described the interior "with tropical paw paws almost coming indoors to join forces with the banana that is really growing and fruiting, right inside the house." Strewe continued to advocate for this disciplinary contest in subsequent years by writing about indoor gardening in New Zealand Modern Homes and Gardens and designing gardens that challenged the boundaries between landscape and the interior. This paper will explore the design strategies of two of Strewe's interior gardens in the 1960s as he developed this aspect of his landscape design practice.
The Importance Of Being Physiologically Relevant: Molecular Methods To Identify Mitochondrial Transfer In Bone Marrow
Authors:   , Carson Georgia
Published: December 2022

Mitochondria are organelles that play a key role in cell metabolism and survival. We assume that mitochondria remain within their eukaryotic host cell, yet mitochondria move between cells; multiple in vitro and in vivo studies have now shown this. However, a comprehensive, tissue-wide, and physiologically relevant exploration of the cells, both cancerous and non-cancerous, that partake in mitochondrial transfer (MT) remains understudied, for cells of the bone marrow as for other tissue. Furthermore, molecular methods of MT identification, methods that leverage the self-contained mitochondrial genome and open the door to quantitative, reproducible, and high-throughput measurement of MT, are scarce.

This thesis comprises design of molecular techniques to determine the prevalence of intercellular MT in murine bone marrow cells, between haematopoietic cells of bone marrow transplants (BMTs), and the acute myeloid leukaemia (AML)-like C1498 line in a murine bone marrow cancer model. Adaptation in a subset of BMTs explored the effect of other cell populations, such as lineage negative (stem-like) cells, adherent (stromal-like) cells, and cells derived from compacted bone, as well as the effect of cell damage on MT. BMTs and the cancer cell line model were carried out on animal strains with at least one mitochondrial DNA (mtDNA) single nucleotide polymorphism (SNP) between cells to allow for MT detection.

MtDNA acquired from these models was examined in protocols designed, optimised, and employed to determine incidence of MT: Allele-Specific with a Blocking reagent (ASB) qPCR; Four-Primer and barcode ligation MinION amplicon sequencing; and Illumina miSeq amplicon deep sequencing. The latter of these could hypothetically identify MT resultant mtDNA sequences at a concentration of 1 in 10,000, although without the assurance of an additional CD45 nuclear control, which was found to be less sensitive.

Infrequent evidence that mitochondria could be transferred amongst the cells of the bone marrow was uncovered while utilising the most sensitive MT identification assay, Illumina sequencing. Although only preliminary, rare, that is, occurring in a minority of samples (5.8%-25%) but strong, that is displaying variant frequencies greater than 0.13 (0.2-0.5) indicative of MT, occurred in bone marrow cell populations, from standard haematopoietic, irradiation-damaged haematopoietic, and cancer cell line samples. Further investigation, preferably with an additional nuclear control SNP and more precise statistical methods, is needed to corroborate this infrequent MT signal in bone marrow cells.

The fundamental importance of mitochondria in biology and human health makes this research critical, as transfer of mitochondria is a proposed as a potential method of therapy resistance in cancers.
A GESTÃO ESCOLAR E GESTÃO DO CURRÍCULO: INTERFACES NECESSÁRIAS PARA A CONSTRUÇÃO DE UMA ESCOLA REFLEXIVA
Authors: ALBUQUERQUE MARIA JOSÉ , AIRES SILVA RODRIGO , DE SOUSA SILVA TAISE HELENA
Published: December 2022

O presente artigo objetiva discutir sobre a contribuição da Gestão escolar e da Gestão do currículo para a construção de uma escola reflexiva, enfatizando considerações sobre elas, explanando a gestão democrática na escola e o papel do gestor e do professor reflexivo frente a essa nova forma de organização escolar e do desenvolvimento curricular. Dessa forma, partimos do seguinte problema de pesquisa: Como a gestão democrática e participativa em substituição de um modelo gerencial escolar hierárquico e inflexível, pode contribuir para a construção de uma escola reflexiva? Para a construção e concretização, este estudo segue com base numa revisão bibliográfica, elegendo algumas fontes teóricas que abordam tais assuntos, como: BRASIL (2004), Luck (2005), Brandão (2003), Libâneo (2005, 2015) Pacheco (2005), Lopes e Macedo (2011), Silva (2008), Gauthier (1998), Alarcão (2008), Tardif (2015) dentre outros. Os resultados deste trabalho apontam que, a gestão democrática participativa e a gestão do currículo formalizadas a partir de posturas reflexivas tanto do gestor quanto dos professores são mecanismos essenciais para a concretização de uma escola reflexiva.
The Patriarch’s Balls: Class-Consciousness, Violence, and Dystopia in George Saunders’ Vision of Contemporary America
Authors: Juliana Nalerio
Published: December 2022

In late 19th Century America, the elite of wealthy New York families were united by the Patriarch’s Balls. The Society of the Patriarch organized lavish balls to foster a content class-consciousness among the society of “The Four Hundred” who mattered, in contrast to the rest who did not. In 21st Century America, the tables have been turned and the class conscious are less able to enjoy the fruits of their labor sans guilt (or the realization of a nasty pun). As Slavoj Zizek asserts in Six Sideways Glances on Violence, contemporary America’s “culture of capital” is marked by the systemic violence that allows the West to maintain its First World status and North American writer George Saunders, for one, knows it. This paper will look at how Saunders returns to those East Coast, greater New York communities in the 21st Century, communities that are now more egalitarian and “open” yet just as worried about keeping up with the Joneses. Writing their stories with a dystopic twist, he intimately explores the anxieties that plague their communities, while also maintaining a sense of the universal in his work that allows for its wider interpretation and relevance to the American national identity in general. Saunders writes as the moral conscience of a community that while “successful” according to American standards, cannot help but feel all the dirtier after the help have cleaned the kitchen.
The Politics of the Electoral Act Amendment and the 2019 General Elections in Nigeria
Authors: Adebiyi Oluwashina Moruf , Oludare Olowa Joseph
Published: December 2022

Amending the 2010 Electoral Act before Nigeria’s 2019 general elections generated huge controversies. The determination of the legislature to get the Electoral Act amended and the refusal of the executive to grant assent to the Electoral Bill raises the question: In whose interest was the proposed amendment? The present article examines the political issues that surrounded the amendment of the Electoral Act vis-à-vis the 2019 elections in Nigeria. The article argues that the electoral amendment bill may not after all be in the interest of a credible election as each political party tried to manipulate the bill and the process of amendment to its advantage. The article is qualitative and theoretical and adopts the thematic analysis to draw contextual inferences. It also adopts the cartel party theory.
KLASIFIKASI TINGKAT KUALITAS DAN KEMATANGAN BUAH TOMAT BERDASARKAN FITUR WARNA MENGGUNAKAN JARINGAN SYARAF TIRUAN
Authors: Humaira B Nurul Isra , Herman Magfira , Nurhikma Nurhikma , Kaswar Andi Baso
Published: December 2022

Pada umumnya, manusia melakukan pemilahan hasil pertanian bergantung pada presepsi mereka terhadap komposisi warna yang dimiliki citra seperti buah-buahan. Masyarakat menilai kualitas dan kematangan tomat dengan cara manual dari tampaknya saja yaitu pada warnanya. Namun, identifkasi dengan cara manual memiliki kelemahan seperti waktu yang dibutuhkan relatih  lama serta menghasilkan produk yang cukup beragam karena keterbatasan visual dan perbedaan persepsi manusia tentang buah tersebut. Oleh karena itu, penelitian ini mengusulkan metode yang dapat digunakan pada klasifikasi kualitas dan kematangan buah tomat yaitu Jaringan Saraf Tiruan. Metode ini dimulai dari tahap akuisisi citra dan preprocessing, kemudian segmentasi citra lalu operasi morfologi, kemudian ekstraksi fitur hingga tahap pelatihan menggunakan JST dan tahap pengujian klasifikasi berdasarkan fitur warna. Hasil pengujian klasifikassi kualitas dan kematangan buah tomat berdasarkan fitur warna menggunakan JST sebesar 90% dengan waktu proses 3.12 detik setiap citra. Dari penelitian tersebut, menunjukkan bahwa metode yang diusulkan memberikan waktu yang efisien terhadap klasifikasi citra tomat.
CLUSTERING PRODUKSI PERIKANAN BUDIDAYA LAUT BERDASARKAN PROVINSI MENGGUNAKAN ALGORITMA K-MEANS
Authors: Firlansyah Alfian , Risal Andi Akram Nur , Adiba Fhatiah , Kaswar Andi Baso
Published: December 2022

Indonesia is a large maritime country, and most of its territorial waters are larger than its land area. Due to the vastness of the oceans, the large number of large and small islands makes Indonesia a potential area for marine cultivation. In general, the existing data based on the Central Statistics Agency (BPS) of Marine Aquaculture Production for each province in Indonesia only applies to production data which only produces detailed data on total marine aquaculture production in tonnes per year, and takes a long time. To classify very large data, a method is needed that can use the K-Means algorithm to classify the highest, middle, and lowest opportunities in the field of marine aquaculture from 2004 to 2018. The results implemented in python consisted of 26 provinces in klaster 1 (C1), 3 provinces in klaster 2 (C2), and 5 provinces in klaster 3 (C3).
PENGEMBANGAN SISTEM REGISTRASI ONLINE AKUN OFFICE 365 DI LINGKUP UNIVERSITAS NEGERI MAKASSAR
Authors: Agung Muhammad , Ismail Rusli , Husda Baso Riadi , Bahar Muhammad Mahdinul
Published: December 2022

Sistem registrasi akun Office 365 UPT TIK Center UNM adalah sebuah sistem penunjang distribusi akun Office 365 untuk mahasiswa, dosen, serta pegawai UNM di lingkungan Universitas Negeri Makassar. Sistem ini diharapkan bisa memudahkan admin memvalidasi data-data mahasiswa, dosen, serta pegawai UNM yang melakukan registrasi untuk mendapatkan akun Office 365. Office 365 merupakan layanan berlangganan office berbasis cloud yang menggabungkan peralatan terbaik untuk memudahkan berbagai macam pekerjaan anda. Dengan menggabungkan aplikasi terbaik di kelasnya misalnya Excel dan Outlook dengan layanan cloud yang canggih seperti OneDrive dan Office Teams, Office 365 memungkinkan anda untuk bisa berbagi dan menghasilkan banyak hal di mana saja, kapan saja pada semua perangkat mobile maupun desktop yang anda gunakan. Microsoft Office 365 menyertakan Office Online (Word, PowerPoint, Excel, dan OneNote), penyimpanan OneDrive tak terbatas, situs SharePoint, dan Yammer. Universitas Negeri  Makassar yang sudah bekerjasama dengan microsoft mengizinkan pengajar dan mahasiswanya untuk menggunakan layanan Office 365 sacara gratis, denagn menginstal aplikasi Office full version secara gratis hingga di 5 PC atau Mac. Penelitian ini bertujuan untuk membangun sebuah sistem registrasi dan adminstrasi untuk mendapat akun Office 365 .Selain itu untuk melihat efisensi dan efektifitas kerja pengelolaan pelayanan yang disediakan oleh pihak universitas dan proses pengembangan sistem informasi ini menggunakan metode pengembangan waterfall, menggunakan DFD untuk mendokumentasikan, menspesifikasikan dan memodelkan sistem. Diimplemntasi menggunakan bahasa pemograman PHP dengan dukungan Jquery, Javascript dan databases MYSQL diatas Freamwork Codeigneter serta software pendukung lainnya. Tahapan pengembangan menggunakan metode waterfall terdiri atas  5 tahapan yaitu tahap analisis kebutuhan sistem, tahap desain sistem, tahap pengodean sistem, tahap pengujian sistem, dan tahap penerapan dan pemeliharaan sistem. Hasil dari penelitian ini diharapkan akan mengahasilkan sebuah sistem registrasi akun Office 365. Dengan implementasi Sistem regitrasi ini, proses distribusi dan validasi akun Office 365 akan tepat sasaran serta efektif dan efisien.
Sistem Informasi Medical Record Pasien Pada Puskesmas Sudu Kec. Alla Kab. Enrekang Berbasis Website
Authors: B Yuanita , Fakhri M. Miftach , Hidayat Wahyu
Published: December 2022

The development of information technology has encouraged humans to complete their routine tasks quickly and efficiently. The work in the service department of puskesmas Sudu is already very dense where the puskesmas has a staff of 67 people, 1 general practitioner, 1 dentist and ±2,530 medical card members from each head of the family. While the mutilation of patient medical records carried out by the medical services department at puskesmas Sudu is still manual. This research was carried out with the aim that the recording of medical records resulting from patient consultations is better recorded and efficiency no longer uses conventional means but has been computerized, so that when data is needed at any time it will be easy in the search. The type of research used is a type of qualitative research, using data collection methods, namely observation, interviews and literature studies where the strategy used is design and creation. This medical record information system was developed using PHP and MySQL programming languages with dreamwaver media editor as well as application testing using the Black Box method. From this study resulted in the design and application of a website-based patient medical record information system at the Puskesmas Sudu Kec. Alla Kab. Enrekang, which can be used as a tool to facilitate medical record officers in the presentation of information and processing patient disease data.
SISTEM INFORMASI UJI KOMPETENSI TENAGA TEKNIK KETENAGALISTRIKAN BERBASIS WEB
Authors: Azhar Azhar , Sari Molita , Atthariq Atthariq
Published: December 2022

Uji kompetensi merupakan sebuah evaluasi yang dilakukan untuk mengetahui seberapa kompeten seseorang dalam suatu bidang, dalam hal ini bidangnya adalah listrik. Ujian yang dilakukan oleh sebagian besar lembaga sertifikasi kompetensi masih secara konvensional yaitu pelaksanaannya menggunakan kertas dan proses pengkoreksiannya berlangsung lama. Proses pengkoreksian tersebut dapat dipermudah dengan sistem uji kompetensi. Pada sistem ini terdapat 114 unit kompetensi dan 3 level soal, peserta akan mengikuti ujian sesuai dengan unit kompetensi yang didaftarkan. Peserta dan asessor hanya dapat mengakses sistem apabila akunnya telah diaktifkan oleh admin. Soal ujian yang terdapat pada sistem ini  ada  5  jenis  yaitu  soal  essai,  pilihan  ganda,  benar-salah,  menjodohkan  dan memberi label. Soal essai dan memberi label akan diperiksa secara manual oleh asesor. Apabila hasil ujian belum diperiksa, maka status hasilnya adalah pending, status akan berubah secara otomatis menjadi kompeten atau belum kompeten bila jawaban telah diperiksa. Proses penilaian dan hasil ujian dari sistem uji kompetensi ini dibuat semirip mungkin dengan uji kompetensi berbasis kertas (paper based). Berdasarkan pengujian yang telah dilakukan, dapat disimpukan bahwa sistem dapat berjalan sesuai perancangan.
Pengembangan Aplikasi Pembimbingan Akademik Berbasis Web pada Jurusan Teknik Informatika dan Komputer Prodi Pendidikan Teknik Informatika dan Komputer UNM
Authors: Mutmainnah Ismail Nurul Iftitah , Andayani Dyah Darma , Rahman Edi Suhardi
Published: December 2022

Penelitian ini bertujuan untuk menghasilkan produk berupa aplikasi pembimbingan akademik berbasis web pada jurusan Teknik Informatika dan Komputer prodi Pendidikan Teknik Informatika dan Komputer UNM dan untuk mengetahui tanggapan mahasiswa dan dosen Pembimbing Akademik terhadap kualitas dari aplikasi pembimbingan akademik berbasis web. Penelitian ini merupakan pengembangan produk perangkat lunak dengan menggunakan metode Research and Development. Penelitian ini menggunakan model pengembangan perangkat lunak prototype (prototyping). Teknik pengumpulan data menggunakan teknik instrumen. Teknik Analisa data yang digunakan adalah functionality suitability, portability, usability, dan performance effieciency. Hasil penelitian pada pengujian aplikasi pembimbingan akademik berbasis web ini berdasarkan standar kelayakan ISO 25010, dalam pengujian functionality suitability dengan kategori baik, pengujian usability dengan kategori sangat baik, pengujian portability dengan kategori baik dan pengujian Performance Efficiency memperoleh nilai yang baik. Berdasarkan hasil penelitian dapat disimpulkan bahwa aplikasi pembimbingan berbasis web layak digunakan untuk dosen Pembimbing Akademik dan mahasiswa di Universitas Negeri Makassar jurusan Teknik Informatika dan Komputer program studi Pendidikan Teknik Informatika dan Komputer sesuai dengan standar kelayakan ISO 25010.
POST TRAINING QUANTIZATION IN LENET-5 ALGORITHM FOR EFFICIENT INFERENCE
Authors: Rifqie Dary Mochamad , Surianto Dewi Fatmarani , Abdal Nurul Mukhlisah , Hidayat M Wahyu , Ramli Hartini
Published: December 2022

Ketika model jaringan saraf tiruan menjadi lebih baik , keinginan untuk mengimplementasikannya di dunia nyata semakin meningkat. Namun, konsumsi energi dan akurasi jaringan saraf tiruan sangat besar karena ukuran dan kompleksitasnya, sehingga sulit untuk diimplementasikan pada embedded devices. Kuantisasi jaringan saraf  ini adalah sebuah teknik untuk dapat memecahkan masalah seperti mengurangi ukuran dan kompleksitas jaringan saraf tiruan dengan mengurangi ketepatan parameter dan aktivasi. Dengan jaringan yang lebih kecil, dimungkinkan untuk menjalankan jaringan saraf di lokasi yang diinginkan. Artikel ini mengkaji tentang kuantisasi yang telah berkembang dalam beberapa dekade terakhir. Dalam penelitian ini, kami mengimplementasikan kuantisasi dalam algoritma lenet-5, yang merupakan algoritma jaringan saraf convolutional pertama yang pernah ada, dan dievaluasi dalam dataset MNIST dan Fashion-MNIST.
Metode Deteksi Cepat Serangan Ganoderma pada Perkebunan Kelapa Sawit dengan Penginderaan Jauh
Authors: Wicaksono William , Rega Prilianti Kestrilia , Setiawan Hendry , Mimboro Prasetyo
Published: December 2022

Di tengah krisis ekonomi dunia saat ini, industri sawit masih mampu menopang perekonomian domestik Indonesia. Oleh karena itu, potensi kerugian akibat penyakit yang terlambat terdeteksi dan mengakibatkan gagal panen harus diantisipasi sejak dini. Penyakit yang paling sering menyerang perkebunan kelapa sawit adalah Ganoderma. Luas area perkebunan kelapa sawit di Indonesia yang sangat besar merupakan tantangan bagi pengelola untuk dapat melakukan monitoring terhadap serangan Ganoderma secara komprehensif. Teknologi penginderaan jauh merupakan salah satu solusinya. Dengan menggunakan Unmanned Aerial Vehicle (UAV) seperti drone citra perkebunan kelapa sawit dapat direkam dengan cepat. Pada penelitian ini, citra UAV dari perkebunan kelapa sawit diproses menggunakan algoritma Convolutional Neural Network (CNN) dengan arsitektur ResNet-34 untuk deteksi pokok pohon kelapa sawit. Pada hasil deteksi kemudian dilakukan ekstraksi nilai rerata RGB (Red, Green, dan Blue) dari setiap pokok pohon. Nilai rerata RGB kemudian digunakan sebagai input pada custom model Artificial Neural Network (ANN) untuk memprediksi status serangan Ganoderma (terinfeksi atau tidak terinfeksi) pada tiap pokok pohon. Akurasi model CNN deteksi pokok pohon (diukur dengan F1-Score) mencapai 84,61% untuk training dan 73,83% untuk testing. Sedangkan akurasi model ANN status serangan Ganoderma mencapai 91% untuk training dan 94% untuk testing. Dengan metode ini pengelolaan lahan terkait serangan Ganoderma dapat dilakukan dengan efektif dan efisien.