bluuebunny/crossref_metadata_2025 huggingface dataset:
An Efficient and Green Microwave-Assisted Synthesis of Some Novel 1,3,4-Thiadiazinan- ones and their Molecular Docking, Computational and Biological Study Analysis
Authors: Sriniv S. , Girija R. , Aruna S. , Elumalai M. , Kotteswaran S.
Published: September 2022

Among the vast number of structurally diverse alkaloids, 1,3,4-thiadiazinan-5-one and its analogues have also been targeted for the exploitation of modern synthetic techniques, possibly due to their good pharmacological properties. This study aims to synthesize 1,3,4-thiadiazinan-5-one by using an efficient and green reaction of aryl aldehyde, hydrazine substituted derivatives and thioglycolic acid. The synthesized compound’s chemical composition is characterized by the use of data from the elementary analysis, IR, Mass, 1H and13C-NMR spectroscopy. Thiadiazinan-5-one derivatives analogue of the 3D-Crystal Protein Target Structure (PDB ID: 4COF) is conducted using Schrodinger Maestro 12.1 computation approach. The findings show no interaction of the hydrogen bond with 4COF protein based on the compound 2A docking. Overall, these 1A to 3Dcompounds are used in drug design and development studies as a chemical compound synthesis. The compounds 3D, 1B, 2D and 3B can also be considered as anti-epilepsy molecules based on the In-silico study. The descriptors for reactivity have been measured using frontier orbital molecular energy of hardness, electrophilicity index and energy gap.
Airplane Detection Based on Unsupervised Deep Domain Adaptation in Remote Sensing Images
Authors: YOUSSEF Youssef BEN , Lyaqini Soufiane , Fakhar Khalid , Abdelmounim Elhassane
Published: September 2022

In this work, we use the detection and localization capabilities of the pre-trained Faster Region Convolutional Neuronal Network (Faster R-CNN) model including Resnet50 as the backbone of the architecture. Our model has been trained with a huge benchmark dataset Common Objects in Context (MSCOCO) as a source domain. The model pre-trained is used in Unsupervised Deep Domain adaptation (UDDA) for airplane detection and localization in Remote Sensing Image (RSI) as a domain target. We evaluate our proposed approach using images containing multi-objects (airplanes) on a different scale and types collected from the public dataset for Object Detection in Aerial Images (DOTA) and different airport images extracted from Google Earth. Extensive experiments in a Cloud environment reveal the usefulness of the proposed approach regarding score. UDDA algorthm proposed is a non deterministic machine learning approach for detecting the airplane in RSI.
The mechanism of microRNA-210-5p targeting YAP1 to regulate IL-1β induced endplate cartilage degeneration
Authors: Kong Lei , Gao Dao-Kuan , Xie Yong- Sheng , Ma Xu-Dong , Shang* Xi-Fu
Published: September 2022

MicroRNAs (miRNAs) have emerged as important factors during intervertebral disc degeneration. The cartilage endplate (CEP) is an important site for solute exchange and the import of nutrients for intervertebral disc degeneration. This study was to determine whether miR-210-5p regulates interleukin-1β (IL-1β)-induced expression of YAP1 (Yes-associated protein 1) in rats cartilage endplate (CEP) cells. Rats cartilage endplate cells were stimulated with IL-1β in vitro. In IL-1β stimulated rats CEP cells, YAP1 was down-regulated and miR-210-5p were up-regulated. Functional analysis(Collagen II、Sox-9、MMP-13 ) showed similar results. Up-regulation of miR-210-5p expression by IL-1β was correlated with down-regulation of YAP1 expression in rat CEP cells. Overexpression of YAP1 can alleviated the inhibitory effect of IL-1β on the phenotype of endplate cartilage degeneration cells. MiR-210-5p participates in IL-1β-induced endplate chondrocyte degeneration by regulating YAP1 expression. Silencing of miR-210-5p delayed intervertebral disc degeneration in rats in vivo, the results suggested that miR-210-5p was an important regulator of YAP1 in CEP cells and may regulate the progression of intervertebral disc degeneration.
Drought-stricken U.S. states have more comprehensive water-related hazard planning
Authors: Jedd Theresa , Smith Kelly Helm
Published: September 2022

Despite the devastating impacts of droughts, the United States lacks a national drought plan. This leaves states to address this challenge in water, hazard, and stand-alone drought plans which are designed to reduce drought vulnerability and to prepare government, industry, and society to cope with its impacts. Yet, there is limited empirical research that evaluates the comprehensiveness of these plans in terms of whether they include a range of measures from preparedness and mitigation to triggers for action and response. To fill this gap, we created an evaluation framework using principles from the drought mitigation literature. We evaluated 171 state-level plans with the framework, and simultaneously collected interview data to contextualize the results. The scoring results are then employed in a statistical analysis of whether states with higher physical exposure to drought have higher planning scores. The study finds states that have experienced more frequent and severe drought plan more comprehensively, suggesting that the occurrence of drought may be an intrinsic driver for planning. The results allow for generalizations about what states are doing to mitigate the effects of drought and suggest that worsening drought may be a driver for states to improve their planning.
CT-based body composition parameters predict the loss of response to infliximab in patients with Crohn’s disease
Authors: Wu Hao , Zhang Yini , Shao Xinyi , Wu Xiaoli
Published: September 2022

Purpose: Although the advent of infliximab has improved clinical outcomes for patients with Crohn’s disease, a large proportion of patients still experience loss of response during treatment. The aim of our study was to explore the association between body composition parameters and the loss of response to infliximab in patients with Crohn’s disease(CD).
Methods:118 patients with CD admitted to the First Affiliated Hospital of Wenzhou Medical University and treated with infliximab from June 2015 to December 2021 were retrospectively enrolled. The body composition of patients was analyzed by computed tomography (CT). The primary outcome measure was the loss of response (LOR). Patients were divided into the Remission group and LOR group to analyze the association between body composition parameters and the loss of response to infliximab.
Results The rate of sarcopenia in the LOR group was higher than the Remission group (83.7% vs. 60.0%, P=0.008). Multivariate analysis showed that females had a lower risk of sarcopenia than males (OR=0.30, 95%CI 0.11-0.81, P=0.017); BMI was significantly associated with sarcopenia (OR=0.68, 95%CI 0.56-0.83, P<0.001); L1 CD and L2 CD had a lower risk of sarcopenia than L3 CD (OR=0.29, 95%CI 0.10-0.83, P=0.021; OR=0.25, 95%CI 0.07-0.87, P=0.028).
ConclusionsSarcopenia was identified as a risk factor for developing LOR in infliximab-treated patients.
Lipid profiles in the cerebrospinal fluid of rats with 6-hydroxydopamine-induced lesions as a model of Parkinson's disease
Authors: Qiu Jiewen , Peng Guoyou , Tang Yuting , Liu Hanqun , Wei Lijian , Su Yilin , Lin Yuwan , Dai Wei , Zhang Zhiling , Chen Xiang , Ding Liuyan , Guo Wenyuan , Zhu Xiaoqin , Xu Pingyi , Mo Mingshu
Published: September 2022

Background
Parkinson's disease (PD) is a progressive neurodegenerative disease with characteristic pathological abnormalities, including the loss of dopaminergic (DA) neurons, a dopamine-depleted striatum, and microglial activation. Lipid accumulation exhibits a close relationship with these pathologies in PD. Few studies on PD have focused on the lipid profile of cerebrospinal fluid (CSF), which may represent an ideal biomarker for disease diagnosis.
Methods
Here, 6-hydroxydopamine (6-OHDA) was used to construct a rat model of PD, and the lipid profile in CSF obtained from model rats was analyzed using lipidomic approaches.
Results
Establishment of this PD model was confirmed by apomorphine-induced rotation behaviors, loss of DA neurons, depletion of dopamine in the striatum, and microglial activation after 6-OHDA-induced lesion generation. Unsupervised and supervised methods were employed for lipid analysis. A total of 172 lipid species were identified in CSF and subsequently classified into 18 lipid families. Lipid families, including eicosanoids, triglyceride (TG), and free fatty acid (FFA), and 10 lipid species exhibited significantly altered profiles 2 weeks after 6-OHDA administration, and significant changes in eicosanoids, TG, CAR, and 3 lipid species were noted 5 weeks after 6-OHDA administration. During the period of 6-OHDA-induced lesion formation, the lipid families and species showed concentration fluctuations related to the recovery of behavior and nigrostriatal abnormalities. Correlation analysis showed that the levels of eicosanoids, TG families and TG (16:0_20:0_18:1) exhibited positive relationships with apomorphine-induced rotation behaviors and negative relationships with tyrosine hydroxylase (TH) expression in the midbrain.
Conclusions
These results revealed that nonprogressive nigrostriatal degeneration induced by 6-OHDA promotes the expression of an impairment-related lipidomic signature in CSF that may function as a biomarker to aid in PD diagnosis, and the level of eicosanoids, TG families and TG (16:0_20:0_18:1) in CSF may reveal pathological changes in the midbrain of PD patients.
Short-term effects of intravitreal dexamethasone implant on choroidal structure in eyes with refractory diabetic macular edema Contributors
Authors: Bilici Serdar , Serbest Enes , Ugurbas Suat Hayri
Published: September 2022

Purpose
To evaluate choroidal structural changes after intravitreal dexamethasone implant (IDI) in eyes with diabetic macular edema (DME) refractory to anti-vascular endothelial growth factor (VEGF) therapy.
Methods
Twenty-three eyes of 14 patients with DME refractory to anti-VEGF therapy were included in this retrospective study. Detailed ophthalmological examinations were recorded and optical coherence tomography (OCT) images were obtained before and 3 months after IDI. Choroidal images were binarized into the luminal area and total choroidal area. Subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) were calculated.
Results
The mean best-corrected visual acuity (BCVA) and central macular thickness (CMT) were improved significantly (from 0.94 to 0.81 LogMAR, p = 0.02, and from 464 to 371 µ, p = 0.01, respectively) after IDI. There were no significant changes in both SCFT and CVI at the end of the follow-up period (from 446.3 to 428.8 µ, p = 0.51 and from 63.1 to 63.7 p = 0.35, respectively).
Conclusion
IDI in eyes with DME refractory to anti-VEGF therapy improves BCVA and CMT but has no significant effect on SCFT and CVI in short term.
Dung Beetle Assembly Affects Nitrous Oxide Emission, Ammonia Volatilizaiton and Nutrient Cycling
Authors: García Carlos C. V. , Dubeux José C. B. , Martini Xavier , Conover Derick , Santos Erick R. S. , Homem Bruno G.C. , Ruiz-Moreno Martin , Silva Izabela A. Gomes , Abreu Daciele S. , Queiroz Luana M. D. , Cleef Flávia O. S. , Santos Mércia V. F. , Fracetto Giselle G. M.
Published: September 2022

This study examined how dung beetle species and assemblage affect nitrous oxide (N2O), ammonia volatilization, and pearl millet [Pennisetum glaucum(L.) R] performance. Seven treatments were applied in pot and they were two controls (only soil and soil + dung without beetles), single species ofOnthophagus taurus(1),Digitonthophagus gazella(2), orPhanaeus vindex[MacLeay] (3); and their assemblages (1 + 2 and 1 + 2 + 3) respectively. After an initial trial assessing gas emissions, pearl millet was planted to assess growth, nitrogen yield (NY), and dung beetle activity after dung application. Dung beetle species increased N2O flow on dung on the 6th day (80 g N2O-N ha− 1day− 1) compared to soil and dung (2.6 g N2O-N ha− 1day− 1). Ammonia emissions varied with the presence of dung beetles (P < 0.05), andD. gazellahad lesser NH3-N on days 1, 6, and 12 with averages of 2061, 1526, and 1048 g ha− 1day− 1, respectively. The soil N content increased with dung + beetle application. Each pot with dung application affected pearl millet herbage accumulation (HA) regardless of dung beetle application, averages ranged from of 5 and 8 g DM pot− 1. A PCA analysis was applied to analyze variation and correlation to each variable, but it indicated a low principal component explanation (less than 80%), not enough to explain the variation in findings. The presence of dung beetles prior to planting improved pearl millet production by enhancing N cycling, although assemblages with the three beetle species enhanced N losses to the environment via denitrification.
Hybrid Arithmetic-Rider Optimization Algorithm as New Intelligent Model for Travelling Salesman Problem
Authors: Krishna Madugula Murali , Majhi Santosh Kumar , Panda Nibedan
Published: September 2022

Travelling Salesman Problem (TSP) is one of the significant NP-hard benchmark problems for performing discrete optimization. In recent times, determining the optimal route mechanism is implemented and ensured as an important mechanism for solving practical applications. In real-time applications, energy-saving, reaching the destination at the assigned time, and identifying the shortest route is very essential. Route determination is researched by different scientists and engineers. Numerous research is done on this problem, and it is still challenging. Therefore, meta-heuristics are involved in this problem as it is inspired by the biological species. This article constitutes the continuation of the work on adapting the TSP using the hybridized algorithm named Arithmetic-ROA (A-ROA). The ultimate aim of the proposed TSP is to reduce the distance travelled by the salesman while focusing on the entire city. For attaining this optimal solution, the novel hybrid A-ROA optimizes the number of the city to be travelled. The results acquired by the new hybrid heuristic are compared with other heuristic algorithms. The computational results confirm that the developed algorithm obtained better results when compared with existing algorithms. The developed optimization algorithm also provides enhanced performance within a realistic amount of computational time.
An improved fuzzy multi-objective nonlinear programming model integrate PSO for water resources optimization allocation under uncertainties
Authors: Ren Chongfeng , Xie Zhishuai , Zhang Yu , Wang Yashi
Published: September 2022

The shortage of water resources has become one of the main factors restricting the development of society, and the impact of the shortage of water resources is particularly obvious in Northwest China in recent years. This paper establishes an inexact fuzzy non-linear multi-objective programming model aiming at the maximum economic benefit and maximum water productivity, which is applied to the actual case of Minqin, Gansu in Northwest China. Improved particle swarm optimization (PSO) is introduced to solve the model, and the optimization scheme of agricultural water resources allocation in the study area is obtained under multiple uncertainties. The results show that the optimization of multi-objective model by IPSO can comprehensively adjust the economic benefits and water productivity. The upper limit of economic benefits can reach 8.84×108 ¥, and the water productivity is 6.29 ¥/m3, which improves the utilization efficiency of water resources and ensures the local economic benefits. The water resources allocation scheme obtained by the multi-objective optimization model can not only provide potential scenarios for local water resources decision-makers, but also provide a reference for the optimal allocation of agricultural water resources in similar areas.
Effects of therapeutic exercise on the motor function of adults with Down syndrome: a systematic review and meta-analysis
Authors: Méndez-Martínez Melanie , Rodríguez-Grande Eliana-Isabel
Published: September 2022

Background Therapeutic exercise exerts positive effects by mitigating or reducing the motor or cognitive changes that people with Down syndrome undergo throughout their life. There are no updated systematic reviews that integrate the evidence available in way that facilitates decision-making for physical rehabilitation teams. This study aimed to assess the effect of different types of physical exercise on the motor function of adults with Down syndrome. Methods We conducted a systematic review and meta-analysis of randomized clinical trials and quasi-experimental studies. The literature search was performed between September 2020 and June 2021 using the PubMed, SCIELO, Epistemonikos, and Lilacs databases. Studies were selected according to pre-determined inclusion and exclusion criteria. The risk-of-bias assessment was performed using the risk-of-bias rating tool. Risk-of-bias assessment and meta-analyses were performed using the RevMan software package. Results Water aerobic exercise significantly increased isometric push-up strength time (mean difference MD = 24.00 [95% CI = 2.66–45.35]; P = 0.03), while combined exercise significantly increased muscle strength both in the upper limbs (MD = 11.93 [95% CI = 4.72–19.14]; P = 0.001) and lower limbs (MD = 18.47 [95% CI = 2.34–34.60]; P = 0.02). Aerobic exercise improved spatiotemporal gait parameters. Aerobic exercise in an aquatic environment and continuous and interval training improved six-minute walk (MD = 43.21 [95% CI = 0.84–85.57]; P = 0.05). The certainty assessment revealed low certainty for all outcomes. Conclusions There was low certainty of evidence for the outcomes proposed in this review. However, therapeutic exercise was shown to be effective in improving muscle strength and gait functionality.
HR-LCMS and Network Pharmacology-based immunity enhancing and pulmonary protection activity of a polyherbal Ayurveda formulation
Authors: Pathak Vijay Kumar , Mahapatra Arun Kumar , Rajagopala S , Gupta Prashant Kumar , Nesari Tanuja Manoj
Published: September 2022

Ayurveda, an integral component of Traditional Indian Medicine systems (AYUSH), advocates preventive and therapeutic approaches to human health care. Ayurveda has a multifaceted contribution to COVID-19 prevention and therapeutics. In addition to vaccination, the AYUSH ministry advocated Bal Ayush Kwatha for the prevention and prophylaxis of COVID-19 among pediatric age. Bal Ayush Kwatha is transformed into jaggery-based syrup for its easy palatability in the pediatric age group and is termed Syrup Bal Ayush Kwatha (SBAK). A search has been made for the computation evidence of SBAK as an immunity enhancer and pulmonary protection. High-Resolution Liquid Chromatography-Mass Spectrometry studies identified 110 botanicals in SBAK. An ADME, in-silico network pharmacology, gene ontology, and KEGG pathway prediction models were constructed for immunity enhancer and pulmonary protection. We find overlapping targets of SBAK botanical out of targets hatched for pulmonary protection and immunity enhancer from the Genecards database. Luteolin, Kaempferol, 4-Hydroxycinnamic acid, and Genistein are the phytoconstituents, and CA2 (Carbonic Anhydrase 2) and ESR2 (Estrogen Receptor 2) are top crucial targets that are responsible for predicted activity through Endocrine resistance and estrogen signaling pathway. Predictive models support the SBAK utility as an immune enhancer and pulmonary protection. Further experimental studies can help in mechanistic understanding of the SBAK. It can also substantiate the wider preventive, prophylactic, and therapeutic utility of Syrup Bal Ayush Kwatha in the pediatric age group.
A Secure Multi-Agent-Based Decision Model Using a Consensus Mechanism for Intelligent Manufacturing Tasks
Authors: Kara M. , Laouid A. , Hammoudeh M. , Karampidis K. , Papadourakis G. , Bounceur A.
Published: September 2022

Accord is an important operation in the mechanism design for multi-agent systems and consequently to applications built for these environments , such as ad hoc networks, virtual organizations, and decision-support tools for smart production systems. Much attention has been given to designing the process for resisting manipulation by strategic voting and decentralized control. The emphasis is on local decision-making based on locally available information and perception of events occurring locally. This manuscript presents a secure decision-support algorithm in a multi-agent system. The proposed consensus-based model serves multiple purposes in production planning and control, supply chain management , and product design and development. In particular, we describe decision-making, the selection of a leader, and the exploitation of limited resources. The importance of the proposal is to ensure robustness in a specific way; in which, decisions are carried out considering that the system is open, which means that the number of agents present is variable at each process. Our model is based on that a group of agents makes different decisions in a task, then the algorithm chooses one of these decisions logically, safe, efficient, and fast and stays away from emotional decisions even in dealing with the decisions of others that affect production.
Efficacy of Gum Arabic as Anti-inflammatory Agent in Sickle Cell Anemia Pediatric Patients : A randomized, double-blind, placebo-controlled Phase III trial
Authors: Abdelmaged DalyaMM , KAddam Lamis AA , Abdelrazig Haydar A , Fadl-Elmula Imad , MohamedSharif Abubaker A , Abdalla Hassan Elhag Hassan , Mohammed Isra Bdraldein Salih , Saeed Amal M.
Published: September 2022

Background: Sickle cell disease is one of the common genetic diseases with an autosomal recessive inheritance. SCD have been acknowledge as an inflammatory condition with several indicators of an inflammatory response involving high level of white blood cell, CRP, cytokines as well as elevated monocytes, neutrophils, platelets and endothelial cells. Oral intake of gum Arabic elevates serum level of short chain fatty acids concentration especially levels of butyrate and propionate. Butyrate is a potent anti-inflammatory, that lowers pro-inflammatory cytokines expression through inhibition of NF-kB. GA works as anti-inflammatory through short chain fatty acids.
Methods: Twenty- one sickle cell anemia patients recruited and giving 30g of gum arabic daily for 12 weeks and levels of CRP, ESR and uric acid were measured before and after full dose of oral GA. Another Twenty- one patient were recruited and this time giving placebo treatment. Same GA investigations were done for placebo group.
Results: Gum Arabic has significant anti-inflammatory effects in SCD patients as CRP level decrease significantly after taking GA.
Conclusion: GA is a potent anti Inflammatory. It reduces Inflammatory markers like CRP in patients with sickle cell disease.
Trial registration: clinicalTrial.gov identifier: NTC04191213. First posted December 9, 219. Retrospective regestriation.
A pilot study to assess the feasibility of a sham anti-inflammatory diet: Can inflammation neutrality and participant blinding be achieved?
Authors: Allison David J. , Agudelo Alexandria Roa , Lawson Arden , Gazzellone Giuseppe , Ditor David S. , Loh Eldon
Published: September 2022

Context: While randomized, double-blind, placebo-controlled trials are the gold standard for investigating the effects of dietary interventions, the complexity of designing such trials has limited their use.
Study Design: Single centre, randomized, double-blind, controlled trial.
Objective: Primary objectives included the assessment of the impact of a sham anti-inflammatory diet on inflammation and participant blinding.
Methods: This dietary advice trial involved participants with spinal cord injury (SCI), randomized to either a sham-diet condition (n=8) or non-dieting control condition (n=8). Participants in the sham-diet group were told they would be randomized to either an anti-inflammatory diet condition, or a sham diet designed to be inflammation-neutral. Participants randomized to the sham-condition completed a diet consultation prior to beginning the diet for a period of 4-weeks. Primary outcomes of interest included the change in inflammation as assessed by plasma concentrations of C-reactive protein (CRP), and participant blinding assessed upon completion of the trial.
Results: All members of the control group and 6 of 8 members of the sham-diet group completed the intervention. Blinding was successful as all 6 members who completed the sham-diet believed they were on the true anti-inflammatory diet. Further, the sham diet was shown to have no significant effect on inflammation over the 4-week intervention period as demonstrated by plasma CRP concentrations.
Conclusion: This pilot study provides preliminary evidence for the utility of a sham-anti-inflammatory diet and could be used to strengthen the design of future dietary interventions utilizing anti-inflammatory diets.
Comparison of the Incidence Rate of Radiation Pneumonitis Observed in Patients with Advanced Lung Adenocarcinoma Treated with Simultaneous Thoracic Radiotherapy and 1G/2G/3G EGFR-TKIs
Authors: Fan Bingjie , Mu Fengchun , Li Butuo , Qin Wenru , Li Haoqian , Wang Chunni , Zou Bin , Wang Shijiang , Wang Linlin
Published: September 2022

Background: The present study aimed to evaluate the incidence rate of radiation pneumonitis (RP) in patients with stage III-IV lung adenocarcinoma treated with first-generation (1G), second-generation (2G), or third-generation (3G) epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) combined with thoracic radiotherapy (TRT).
Methods: Patients with stage III-IV lung adenocarcinoma simultaneously treated with 1G, 2G, or 3G EGFR-TKIs and TRT between January 2015 to December 2021 at Shandong Cancer Hospital and Institute were screened in this retrospective study. The clinical and imaging grades of RP were evaluated using the Common Terminology Criteria for Adverse Events (version 5.0) grading system for pneumonitis and pulmonary fibrosis, respectively.
Results: A total of 200 patients treated with EGFR-TKIs were enrolled in this study, including 100 patients who were treated with 1G EGFR-TKIs, 50 patients who were treated with 2G EGFR-TKIs, and 50 patients who were treated with 3G EGFR-TKIs (patients matched in a 2:1:1 ratio for tumor characteristics). Patients in the three groups were simultaneously treated with TRT. The overall incidence of clinical RP in the 1G, 2G, and 3G EGFR-TKI groups was 29%, 48%, and 28% (p=0.043), respectively, and that of imaging RP was 33%, 58%, and 36% (p=0.010), respectively. The incidence of RP with a clinical grade ≥3 in the three groups was 14%, 28%, and 12% (p=0.055), respectively, and that with an imaging grade ≥3 in the three groups was 11%, 32%, and 10% (p=0.002), respectively. In the 58 patients with both clinical and imaging assessments of RP, the median time from TRT to imaging assessment of RP was 62 d, and the median time of RP according to the clinical symptoms was 84 d (p=0.0397).
Conclusion: Compared with 2G EGFR-TKIs combined with TRT, 1G or 3G EGFR-TKIs combined with TRT achieved a lower incidence of RP. The imaging manifestation of RP occurs earlier than the clinical symptoms, suggesting that imaging findings can provide an early warning of clinical symptoms.
Coinheritance of pathogenic variants in ATM and BRCA2 in families with multiple cancers: a case series
Authors: Freire Maria Valeria , Martin Marie , Segers Karin , Sepulchre Edith , Leroi Natacha , Kalantari Hassan , Wolter Pascal , Collignon Joëlle , Polus Marc , Plomteux Olivier , Josse Claire , Bours Vincent
Published: September 2022

Purpose. Pathogenic variants (PVs) in BRCA2 and ATMgenes have been linked to an increased risk of various cancers. BRCA2and ATM are part of the homologous recombination pathway, but the tumor risk in patients with simultaneous PVs in both genes remains largely unknown. In this study we describe four patients from three families with multiple cancers who coinherited PVs in BRCA2 and ATM genes.
Methods. PVs in the patients were identified using NGS sequencing of the DNA and were confirmed by Sanger sequencing.
Results. The first family included a 67-year-old male with kidney, prostate, and pancreatic adenocarcinomas, and his daughter diagnosed with breast cancer at 29 years. In the second family, a 28-year-old female had breast cancer, while a male from the third family was diagnosed with prostate cancer at the age of 49, gastric cancer one year later and pancreatic cancer at 64. The three identified BRCA2 PVs were nonsense variants previously described as pathogenic, leading to a severely truncated or absent protein due to nonsense-mediated mRNA decay. Two of the ATM variants were previously reported as pathogenic, while the third one affects a conserved splice site.
Conclusions. The early age of diagnosis and the development of multiple cancers in the reported patients indicate a very high risk of cancer in double heterozygous patients, carrying PVs in the BRCA2 and ATM genes.
Developing Prototype of Case-Based Reasoning System for Personalized Medical Care for Patients with Diabetes Mellitus Type 2
Authors: Dejene Milkesa , Alemu Solomon , Jimma Worku
Published: September 2022

Personalized medical care is an individualized approach to managing and treating diseases in the healthcare system. It follows the personalized medicine concept and has recently received much attention from the governing, scientific and healthcare diseases communities worldwide. Personalized medicine is speedily impacting how patients are managed and treated and also how healthcare delivery is channelling its resources to maximize patient benefits. The management of Diabetes Mellitus Type 2 consists of major lifestyle (dietary pattern), drug administration and physical exercise. The main objective of this study was to develop a Case-based reasoning system for personalized medical care for patients with Diabetes Mellitus Type 2. Design science within knowledge engineering method and data gathering tools such as semi-structured interviews and document analysis were employed to develop a prototype system. The domain experts were selected by using the purposive sampling technique. The knowledge acquired from domain experts and through document analysis was modelled by using the hierarchical conceptual modelling method, and cases were generated and represented with the feature-value format. The prototype was implemented by using JCOLIBRI software and scored an F-Measure of 84% and user acceptance of 86.2% and 82%, respectively. Applying a case-based reasoning system in personalized medical care is very important to improve the quality of service delivery to address each patient’s case through unique characteristics/attributes such as age, gender, blood pressure, fast blood sugar and others. Even if the porotype registered promising results, future research work is expected from different scholars in personalized medicine for more improvement.
Improving Healthcare Access for the Underserved in Northern Nigeria: Can the Patent Medicine Vendors (PMVs) Really Help?
Authors: Ibitoye Oluwasegun John
Published: September 2022

To address the health workforce deficit in underserved communities, the Federal Government of Nigeria is contemplating a licensing policy to delegate the provision of some basic health services to patent medicine vendors (PMVs) manned by a skilled health workforce. However, it remains unclear whether residents of underserved communities intend to receive these healthcare services through PMVs. We, therefore, sought to assess the intention to receive basic healthcare from PMVs among 665 heads of households from randomly selected 40 underserved communities in two northern Nigeria states. We used an interviewer-administered questionnaire to collect data between December 2021 and February 2022 for this cross-sectional study. The data were analyzed with STATA version 16. We used the Chi-square test to investigate the factors associated with ‘intention’ and Binary logistic regression to identify its predictors. The level of statistical significance was determined at P<0.05. We found that 38.8% of the underserved intend to receive basic health services through PMVs and that respondents who reside in rented buildings or temporary shelters and those who have a high level of trust in PPMVs had higher odds of intending to receive healthcare through PMVs. These findings suggest that PMVs can reach slightly above one-third of the underserved with healthcare. We recommend that healthcare administrators should consider designing additional complementary interventions that can be coherently implemented alongside this initiative to significantly improve healthcare access among the underserved. Keywords: Access, Communities, Healthcare, Intention, Workforce.
The Role of Social Workers in the Care of Autism: A Systematic Literature Review
Authors: Olaitan Oluwayemisi Abiodun
Published: September 2022

The Social Work profession is a caring professional whose primary mission is to assist in meeting the basic needs of individuals, families, and communities, especially the vulnerable, the oppressed, and other key populations, through different forms of empowerment. Included in these groups are persons with autism spectrum disorder, whose care involves various professionals. The role of professionals like psychiatric doctors and nurses, psychologists, behavioral therapists, and occupational therapists are well defined but the role of social workers, who are presumably the first contact with autistic people, is not yet clearly defined. This study explores the opinions of various scholars on the roles of social workers in the care of autism spectrum disorder with the aim of systematizing these different opinions, thereby delineating the professional responsibilities of social workers in the care of autism. The method used in this study is the systematic literature review of journal articles, books, and conference presentations whose main discussions concern the roles of social workers in the care of persons with autism. The review shows that social workers do have a significant role to play in the care of autism, even though the community of health professionals and the caregivers of persons with autism are not aware of the full scope of the role of social workers in the care of autism. The study recommends that this gap needs to be bridged with increased awareness and sensitization. Also, social work educators need to include the care of persons with disability in the social work curriculum in the various training institutions. Keywords: Autism, Care, Role, Social Workers.
The Role of Group Antenatal Care in Reducing Maternal Morbidity and Mortality Rate Among Pregnant Mothers Attending Primary Health Care Facilities: A Case Study of Angwan Waje PHCC in Keffi LGA of Nasarawa State, Nigeria
Authors: Umar Mohammed Abdullahi
Published: September 2022

The increasing rates of maternal morbidity and mortality has reached an alarming situation despite numerous antenatal care attendances by the pregnant mothers before the end of their pregnancy period. This tragedy posed questions on the authenticity and quality of ante-natal care services provided to pregnant mothers at the various primary health care facilities in the LGA. Earlier, Ante Natal Care services flow declined due to poor access, attitude of services providers and traditional belief. The main objective of this study is to examine the role played by the group antenatal care services in participatory learning session that led to the reduction in maternal morbidity and mortality rates. The study was conducted on 450 pregnant mothers attending primary health care facility Angwan Waje with catchment area population of 50, 180 people that rally round 7 settlements with annual target population of 2,158 as pregnant mothers. The method used during the study was cross sectional study design with mixed of both qualitative and quantitative data collection methods using simple random sampling on pre - tested questionnaire. Information generated from the data collection were analyzed using Statistical Package for the Social Sciences (SPSS) 20.0 software to ascertain results for better interpretation and presentation. Additionally, a focused group discussions and key informant interviews were held with the health care providers including the ante-natal care focal person and community representatives on their experiences and insight in Group ante natal care services. Keywords: Group Ante natal Care, Primary Health Care Facility, Health Care Providers.
Professions of Muslim Men in the Hacıkoy District According to the Population Register dated 1845-1846
Authors: ÇELİK Havva , KEÇECİ KURT Songül
Published: September 2022

İnsanlık tarihi içerisinde birey yaşamını idame ettirmek için bulunduğu bölgenin coğrafi şartlarına, imkânlarına, toplumun sosyo kültürel özelliklerine göre birçok uğraş edinmiştir. Genel olarak bu uğraşlardan bazıları insan ve hayvan gücüne, el emeğine ve özellikle toplumun ihtiyaçlara göre şekillenmiştir. Zaman içerisinde uğraş veya iş dediğimiz ifadeler meslek kavramına dönüşmüştür. Günümüzde meslek; planlı bir yöntem ile bilgi ve becerilere dayalı, belli bir eğitimle elde edilen, insanlara faydalı mal üretmek, hizmet vermek ve maddi kazanç karşılığında yapılan iş olarak tanımlanmıştır. Ancak tarihi süreçte bazı yönlerden farklılık gösterdiği para kazanmak ifadesi ile birlikte değiş tokuş şeklinde bir sistemin olduğu da görülmektedir. Meslek geçmişte ve günümüzde var olan, gelecekte de var olmaya devam edecek bir kavramdır. Dolayısıyla toplumları sosyo ekonomik bağlamda değerlendirmek açısından meslekler hakkında bilgi sahibi olmak zorunlu hale gelmiştir. Osmanlı Devleti’nde yapılan ilk nüfus sayımlarında o dönemde icra edilen meslekler hakkında da bilgiler yer almaktadır.

Bu çalışmada Sivas Vilayetinin Amasya Sancağına bağlı Hacıköy Kazâsına ait Cumhurbaşkanlığı Devlet Arşivleri Osmanlı Arşivi Nüfus Defterleri fonunda 2198 numaralı müslim nüfus defteri üzerinden 19. yüzyılın ortalarında bölgede icra edilen meslekler tespit edilmeye çalışılmıştır. Çalışmanın temel kaynağını oluşturan 1845-1846 yılına ait bu defter Hacıköy’ün 4 mahalle ve 6 köyünün nüfus kayıtlarını kapsamaktadır. Okunamayan birkaç meslek haricinde bu mahalle ve köylerde birbirinden farklı 66 meslek çeşidinin olduğu görülmüştür. Aynı dönemde Osmanlı ülkesindeki Müslümanların icra ettiği mesleklere oranla önemli ölçüde çeşitlilik arz ettiği görülmektedir. Bu meslekler vasıtasıyla Hacıköy’ün ekonomik ve sosyal durumu ile ilgili de bilgiler edinilebilmektedir.
Pengembangan Lembar Kerja Mahasiswa PBL Berorientasi Kemampuan Pemecahan Masalah Perkuliahan Biologi Dasar
Authors: Fajarianingtyas Dyah Ayu , Hidayat Jefri Nur
Published: September 2022

Pembelajaran berorientasi masalah menjadi salah satu pendekatan pembelajaran yang melatih kemampuan problem solving mahasiswa. Pemberian suatu permasalahan serta proses mencari jawaban dalam pembelajaran dapat membantu mahasiswa untuk dapat lebih mudah mengingat materi yang dipelajari. Tujuan penelitian adalah mengembangkan Lembar Kerja Mahasiswa (LKM) berbasis PBL bertemakan biologi dasar yang valid dan efektif. Subjek penelitian adalah mahasiswa semester satu yang memprogram mata kuliah Biologi dasar. Model penelitian yang digunakan merujuk model penelitian pengembangan yang dikembangkan Borg Gall (1983). Hasil penelitian menunjukkan bahwa LKM yang dikembangkan valid dengan nilai persentase 90% (kategori sangat baik).  Pengembangan LKM dikatakan efektif dilihat dari adanya peningkatan kemampuan pemecahan masalah sebesar 0,47 (kategori sedang) berdasarkan  N-gain. LKM ini memiliki karakteristik bahan ajar dirancang situasi bermasalah yang tepat bagi mahasiswa IPA di Universitas Wiraraja.
Reflexões Acerca das Práticas do Núcleo de Educação Ambiental da Universidade Evangélica de Goiás, Brasil (2016 – 2021)
Authors: Tavares Giovana Galvão , Dutra e Silva Maria Fernandes Gomide , Dutra e Silva Anderson , Silva Allyson Barbosa da , Braz Vivian da Silva , Rosseto Lucimar Pinheiro , Argolo Eduardo , Lima Ricardo Elias do Vale
Published: September 2022

Este artigo tem por objetivo apresentar relatos de experiência do Núcleo de Educação Ambiental (NEA) da Universidade Evangélica de Goiás (UniEVANGELICA) expondo sobre as práticas de educação ambiental e os processos educativos desenvolvidos no NEA, com ênfase nos projetos Circuito Ambiental, Escola da Natureza, e Educação Ambiental na Universidade Aberta da Pessoa Idosa. Trata-se de um relato de experiência em que se apresenta o papel institucional NEA na Política de Desenvolvimento Sustentável e Educação Ambiental da UniEVANGELICA. O NEA, por meio de seus projetos, busca construir um pensamento sobre a sustentabilidade ambiental e promover a sensibilização ambiental.
Enchente Anunciada: A Construção do Desastre Socioam-biental no Município de Saudades, Santa Catarina – Brasil
Authors: Moretto Samira Peruchi , Rodrigues Adriano Vanderlei Michelotti
Published: September 2022

O município de Saudades, localizado no oeste de Santa Catarina, foi ocupado de forma mais intensa no século XX. Tal processo de ocupação, não levou em consideração as cheias do rio que corta o município. O objetivo do presente trabalho é analisar como a inundação que ocorreu no município de Saudades em 2015, se tornou um desastre socioambiental, assim como, entender quais as ações antrópicas que estavam ligadas a este acontecimento. Para atingir tais objetivos utilizou-se o aporte teórico da História Ambiental e História dos desastres socioambientais. Como fontes foram utilizados periódicos de circulação local, relatórios governamentais e dados do IBGE. Constatou-se que mesmo as enchentes sendo recorrente na memória dos moradores de Saudades, pouco foi realizado para conter ou diminuir os impactos socioambientais causados pelas cheias.
O papel da Soja no Desenvolvimento Agronômico do Cerrado Brasileiro
Authors: Boaventura Kárita de Jesus , Melo e Silva Neto Carlos de , Dutra e Silva Sandro
Published: September 2022

Em 2020, o Brasil tornou-se o maior produtor global de soja. O avanço deste produto no Brasil está associado a processos históricos de desenvolvimento econômico, considerado por alguns pesquisadores como um caso particular de revolução verde no mundo. Entre os biomas brasileiros, o Cerrado tem se destacado como o maior produtor de soja. Este estudo investigou os processos históricos da soja, a partir de análise documental sobre o papel da Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) no que se refere às pesquisas de desenvolvimento tecnológico e agronômico dessa cultivar, especificamente para o Cerrado. A metodologia utilizada foi a de análise bibliográfica e documental, sobretudo a partir dos relatórios anuais da EMBRAPA Cerrados, com recorte temático nos estudos de soja. Os resultados evidenciam intercâmbios científicos e institucionais, assim como modelos e estratégias voltados para a expansão dessa cultivar no Cerrado.
Achievements and Bottlenecks of PEGylation in Nano-delivery
Systems
Authors: Shen Ruoyu , Yuan Hong
Published: September 2022

Poly(ethylene glycol) (PEG) has been widely applied in biomedical field as a gold standard. The conjugation of PEG to proteins, peptides, oligonucleotides (DNA, small interfering RNA (siRNA), microRNA (miRNA)) and nanoparticles, also known as PEGylation, is a common method to improve the efficiency of drug delivery and pharmacokinetics in vivo. The effect of PEGylation on the in vivo fate of various formulations has been and continues to be extensively studied based on the successful PEGylation of proteins to improve in vivo circulation time and reduce immunogenicity. The PEG shell protects the particles from aggregation, immune recognition, and phagocytosis, thereby prolonging the in vivo circulation time. This article mainly describes the development background, advantages and applications of PEGylation in the field of drug delivery, its defects or development bottlenecks, and possible alternatives.
In silico Molecular Modelling and Docking Studies on Kinase Inhibitors as
Potential Anti-Cancer Target in HER2-associated Breast Cancer
Authors: Gupta Binni , Tiwari Apoorv , Taj Gohar , Pal Neeraj , Malik Rashmi , Kumar Sundip
Published: September 2022

Breast cancer is one of the most frequent invasive malignancies in women globally and the
leading cause of mortality. The HER2 target is an important therapeutic option for treating breast cancer.
In the present study, efforts have been made to virtually screen the natural kinase inhibitors
through molecular docking. A total of 800 HER2 protein inhibitor compounds were selected to screen
out the potential inhibitors of the HER2 protein. The docking study demonstrated that these HER2
protein inhibitors confirm the strong binding interaction with HER2 protein based on the docking
score, indicating that kinase inhibitors can play a major role in preventing breast cancer. Among all
the inhibitors, the flavanone compound named 6-C-(3-Hydroxyisopentyl) eriodictyol, IUPAC: 2-(3, 4-
dihydroxyphenyl)-5, 7-dihydroxy-6-(3-hydroxy-3-methylbutyl)- 2, 3-dihydrochromen-4-one observed
to have the maximum docking score value of (-8.717), indicating the highest binding affinity with
HER2 protein which might serve as the promising compound for the development of a new class of
drug to combat breast cancer.
Green Recipes for Pyrimidine
Authors: Patil Pradnya , Ansari Afrin , Tauro Savita. J. , Nadar Sahaya
Published: September 2022

Pyrimidines serve as key structural components in chemical frameworks and biological
processes. Several pyrimidine analogues have been produced over the years by means of traditional
methods that necessitated large amounts of solvents, reagents, and, most importantly, additional
time, which has led them to become prohibitive. These procedures are now being replaced with
more cost-effective adaptive methodologies that incorporate one-pot synthesis and greener approaches
involving various green solvents and catalysts. The current review covers a number of
green synthetic techniques, including ultrasound-assisted synthesis, visible light irradiation synthesis,
solvent-free synthesis, catalyst-free synthesis, microwave-assisted synthesis, and green catalyst
synthesis for the synthesis of pyrimidine derivatives. Accordingly, it integrates different strategies
to synthesize heterocyclic pyrimidine analogues in a well-organized manner.