bluuebunny/crossref_metadata_2025 huggingface dataset:
Systemic Immune Inflammatory Index as Predictor of Blood Pressure Variability in Newly Diagnosed Hypertensive Adults Aged 18–75
Authors: Karaca Yücel , Karasu Mehdi , Gelen Mehmet Ali , Şahin Şeyda , Yavçin Özkan , Yaman İrfan , Hidayet Şıho
Published: November 2024

Background: Accumulating evidence from clinical trials, large registries, and meta-analyses of population studies shows that increased Blood Pressure Variability (BPV) is predictive of Cardiovascular (CV) outcomes, independently of the average Blood Pressure (BP) values. One of the mechanisms explaining the relationship between BPV and target organ damage is the inflammatory response. The Systemic Immune Inflammation Index (SII), which relies on peripheral blood cell counts, including platelets, neutrophils, and lymphocytes, has emerged as a predictor of prognosis and outcomes in various diseases. The aim of this study was to investigate the association of the SII with Ambulatory Blood Pressure Variability (ABPV) in newly diagnosed hypertensive patients. Methods: This study was designed as a cross-sectional observational study. A total of 1606 consecutive newly diagnosed Hypertension (HT) patients were included in the study. The population was evaluated across 3 different categories according to HT grades (5 groups), eligibility for antihypertensive therapy (2 groups) and ABPV levels (2 groups). Results: Significant differences were observed between ABPV groups in terms of Neutrophil to Lymphocyte ratio, Platelet to Lymphocyte ratio, glucose, SII, high-sensitive CRP, HT grade, Inter-Ventricular Septum, Posterior Wall thickness, and Left Ventricular Mass (p < 0.005). There was a significant relationship between SII and ABPV (r: 0.619, p < 0.05). At the cutoff value of 580.49, SII had 77% sensitivity and 71% specificity for ABPV > 14 (AUC: 0.788). Conclusions: SII may assist in developing an early treatment approach to minimize complications in patients with high ABPV who are at a higher risk of CV events.
Comparison of the Clinical Evaluation of Digital Tooth Shade Determination Using an Intraoral Scanner with Proven Subjective and Objective Methods
Authors: Budde Nicolai , Arnold Christin , Wienke Andreas , Schweyen Ramona
Published: November 2024

Background/Objectives: Despite the increasing use of chromatic intraoral scanners, color determination is often performed visually, offering poor reliability and validity. In this study, we aimed to compare the reliability and validity of the tooth shade determination tool of an intraoral scanner (Trios3 Color) with that of two dental spectrophotometers (VITA Easyshade Advance 4.0 and SpectroShade Micro) and with visual determination using the VITA 3D-Master shade guide. Methods: In vivo tooth shade determination was performed on 33 participants using positioning splints for the right central incisor. Repeated measurements assessed the reliability in determining the percentage agreement with VITA 3D-Master shades. VITA Easyshade measurements were used as reference values for validity. The metric value Delta E (ΔE) in the International Commission on Illumination L*a*b* color space was compared to the reference, with ΔE greater than 1 indicating visible differences and a maximum value of ΔE 6.8 being clinically acceptable. Results: The reliabilities of VITA Easyshade, the intraoral scanner, and SpectroShade Micro were 75.8%, 87.9%, and 89.9%, respectively. The visual method had an agreement rate of 20.6%. Validity values, compared with the reference value, were ΔE 3.8 (clinically acceptable), 8.3, and 7.4 (the latter two both being clinically unacceptable) for the intraoral scanner, area-measuring device, and visual method, respectively. Conclusions: The intraoral scanner is a reliable and valid tool for tooth shade determination and is superior to the visual method in both aspects.
Integrated Analysis of Remdesivir and Paxlovid in COVID-19 Patients: A Personalized Approach to High-Risk Individuals for Severe Evolution
Authors: Fitero Andreea , Negrut Nicoleta , Popa Anca , John Harrie Toms , Ferician Anca Cristina , Manole Felicia , Marian Paula
Published: November 2024

Background/Objectives: COVID-19 led to a pandemic that has brought misery to millions of people but more so to those with pre-existing conditions. For this infection, several antiviral drugs were employed, including remdesivir (R) and Paxlovid (nirmatrelvir/ritonavir (NR)). Methods: The current study compared the effectiveness of remdesivir and Paxlovid treatment for COVID-19 patients with comorbid conditions. Data from a cohort of 151 adult patients with COVID-19 who also had associated comorbidities were used in this study. These patients were treated with antivirals according to local guidelines. The subjects included 78 case-patients assigned to group R and 73 to group NR. Results: In group NR, a considerable improvement in oxygen saturation was seen in the first 24 h of treatment (p = 0.010), but the levels were significantly higher from the second day of treatment (p < 0.001) in group R of patients. At the end of the 5 days of treatment, the oxygen saturation improved statistically significantly compared to the admission day, but only in the R group (95.11 ± 1.80; 91.76 ± 1.80; p < 0.001). Conclusions: Both drugs can be considered a breakthrough in the current treatment approach to the COVID-19 disease since they provide readily available options that can alleviate the severity of the disease and, hence, the prognosis of patients. That is why their effectiveness relies on the correct administration time and choosing the patient with suitable characteristics regarding the presence of comorbidities and the likelihood of the critical further development of the process.
Characteristics of Multisystem Inflammatory Syndrome in Children Across COVID-19 Variants in Vojvodina
Authors: Vijatov-Đurić Gordana , Milanović Borko , Barišić Nenad , Ivetić Jelena , Đuretić Andrea , Kesić Jelena , Ležakov Ognjen , Vorgučin Ivana , Vilotijević-Dautović Gordana , Ristić Mioljub , Koprivšek Katarina , Stojanović Vesna
Published: November 2024

Background/Objectives: To investigate if the severity and presentation of multisystem inflammatory syndrome in children (MIS-C) vary between different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. Methods: This retrospective study included 59 patients aged 0–18 years, diagnosed with COVID-19 and MIS-C, treated and monitored over a one-year period after discharge from hospital. The patients were grouped according to the predominant SARS-CoV-2 variant. The predominant variant of SARS-CoV-2 was assumed by the date of hospitalization. The following patient data were collected: demographic data (age, sex), information on comorbidities, body mass index, clinical data (fever and duration of febrile periods, symptoms of Kawasaki-like phenotypes, and presence of respiratory, cardiovascular, gastrointestinal, neurological and other symptoms), and laboratory and imaging findings. Results: In total, 24 (41%), 19 (32%), and 15 (25%) patients were diagnosed with MIS-C during the Alpha, Delta, and Omicron periods, respectively (63.8% were males; 36.2% were females). Comorbidities were present in 49% of patients. Respiratory symptoms were the most common during the Delta period (73%, p = 0.028). There was no statistically significant difference in the occurrence of other symptoms, laboratory findings, treatment, complications, and long-term outcomes between groups. Conclusions: No significant correlation was found between hospitalization date (used to estimate COVID-19 variant) and presentation/severity of MIS-C.
Prosaposin/Saposin Expression in the Developing Rat Olfactory and Vomeronasal Epithelia
Authors: Kitamura Kai , Saito Kyoko , Homma Takeshi , Fuyuki Aimi , Onouchi Sawa , Saito Shouichiro
Published: November 2024

Prosaposin is a glycoprotein widely conserved in vertebrates, and it acts as a precursor for saposins that accelerate hydrolysis in lysosomes or acts as a neurotrophic factor without being processed into saposins. Neurogenesis in the olfactory neuroepithelia, including the olfactory epithelium (OE) and the vomeronasal epithelium (VNE), is known to occur throughout an animal’s life, and mature olfactory neurons (ORNs) and vomeronasal receptor neurons (VRNs) have recently been revealed to express prosaposin in the adult olfactory organ. In this study, the expression of prosaposin in the rat olfactory organ during postnatal development was examined. In the OE, prosaposin immunoreactivity was observed in mature ORNs labeled using olfactory marker protein (OMP) from postnatal day (P) 0. Immature ORNs showed no prosaposin immunoreactivity throughout the examined period. In the VNE, OMP-positive VRNs were mainly observed in the basal region of the VNE on P10 and showed an adult-like distribution from P20. On the other hand, prosaposin immunoreactivity was observed in VRNs from P0, suggesting that not only mature VRNs but also immature VRNs express prosaposin. This study raises the possibility that prosaposin is required for the normal development of the olfactory organ and has different roles in the OE and the VNE.
Surgical and Non-Surgical Approach for Tear Trough Correction: Fat Repositioning Versus Hyaluronic Acid Fillers
Authors: Christodoulou Stylianos , Tzamalis Argyrios , Tsinopoulos Ioannis , Ziakas Nikolaos
Published: November 2024

Objective: This paper compares two popular techniques for tear trough correction—fat repositioning and hyaluronic acid (HA) fillers—highlighting their efficacy, safety profiles, patient satisfaction, and associated complications. Methods: A narrative review of 20 studies comparing fat repositioning and HA fillers was conducted, focusing on parameters such as duration of results, volume restoration, complication rates, and patient satisfaction. Results: Fat repositioning provides long-lasting results but carries higher surgical risks compared with HA fillers. The transconjunctival approach is suitable for patients with minimal skin excess. The supraperiosteal plane allows for a quicker procedure and, despite postoperative edema and temporary irregular contouring, shows no difference in final cosmetic outcomes compared with other planes. Internal fixation reduces the risk of fat relapse and skin scarring but carries the risk of suboptimal positioning. HA fillers offer immediate, minimally invasive results but require periodic maintenance. The use of a cannula reduces the risk of vascular occlusion. Combining a high G’ filler for the midface with a low G’ with low hydrophilicity for the tear trough reduces the amount of filler needed and prolongs the results. Both surgical and non-surgical methods are effective, depending on patient needs and anatomical considerations. Conclusions: Fat repositioning is ideal for patients seeking long-term correction and are willing to undergo surgery, while HA fillers suit those preferring non-invasive treatments with customizable, short-term effects. Both techniques have pros and cons that must be matched to patient goals and conditions.
Functional Characterisation of GmGASA1-like Gene in Glycine max (L.) Merr.: Overexpression Promotes Growth, Development and Stress Responses
Authors: Khalifa Mohamed A. S. , Zhang Qi , Du Yeyao , Amin Nooral , Dong Baozhu , Wang Piwu
Published: November 2024

The presence of Gibberellic Acid-Stimulated Arabidopsis, GASA, gene family has been reported in many important plants, playing roles in various aspects of plant biology but little has been uncovered in soybeans. Soybean is one of the major plants providing nutrition for humans and livestock globally. In this study, we overexpressed a novel GASA gene (GmGASA1-like) in Glycine max and conducted bioinformatic analyses, evaluated the T2 transgenic line in an open field, and applied major stressors along with the growth promoter GA3 to investigate the potential functions of the GmGASA1-like gene. The results of bioinformatics implied that the GmGASA1-like gene is regulated by GA3, and its protein has the potential to influence key processes of plant growth and development. The transgenic plants (JN74-OE) were significantly taller and had a larger canopy in the field trial at the R1-growth stage and demonstrated superiority in some seed quantity and quality traits after harvesting. Under abiotic stresses (including cold, heat, and drought) and spraying of GA3, the level of GmGASA1-like gene expression in JN74-OE exceeded the levels measured before the treatments. Notably, the highest expression level was observed during the drought stress treatment. Photosynthesis pigments levels in both the overexpressed lines and the control group showed no significant differences. In summary, this study sheds light on the multifaceted roles of the GmGASA1-like gene, impacting soybean plant architecture, seed traits, and stress responses. Ultimately, this research paves the way for a more productive and sustainable soybean industry.
Preparation and Characterization of Mechanical Properties of HAP/45S5 Bioglass Laminated Ceramic Composites via Spark Plasma Sintering
Authors: Meng Ye , Li Xinge , Yun Bing
Published: November 2024

Hydroxyapatite (HAP) displays a high degree of similarity to the inorganic components that make up roughly 70% of human hard tissue, and it possesses exceptional biological activity and biocompatibility. It is currently internationally recognized as the most biologically active hard tissue implant material. However, its substandard mechanical properties have significantly limited the application of HAP in areas requiring load bearing or in the repair of large bone defects. In this study, HAP/45S5 bioglass laminated ceramic composites were consolidated using the spark plasma sintering (SPS) technique. The grain growth and phase transformation of HAP and 45S5 bioglass were examined at various sintering temperatures. The mechanical properties of the laminated composites were investigated. At 950 °C, the flexural strength and fracture work of the sintered body were (153.22 ± 7.7) MPa and (2049 ± 34) J·m−2, respectively. These results corresponded to the load–displacement curves and showed that the composites met the mechanical performance requirements of the support material.
Polyhydroxyalkanoates: Medical Applications and Potential for Use in Dentistry
Authors: Ben Abdeladhim Rim , Reis José Alexandre , Vieira Ana Maria , de Almeida Catarina Dias
Published: November 2024

Polyhydroxyalkanoates (PHAs) are promising biopolymers as an alternative to traditional synthetic polymers due to their biodegradability and biocompatibility. The PHA market is blooming in response to the growing demand for biodegradable and environmentally friendly plastics. These biopolyesters are produced and degraded by a variety of microorganisms, making them environmentally friendly, while offering benefits such as biocompatibility (when adequately processed) and biodegradability. Their versatility extends to various areas, from biomedicine to agriculture and composite materials, where they pave the way for significative innovations. In the field of regenerative medicine, some PHAs have key applications, namely in vascular grafts, oral tissue regeneration, and development of self-healing polymers. In addition, PHAs have the potential to be used in the creation of dental implant materials and dental medical devices. PHAs can also be used to encapsulate hydrophobic drugs, providing an approach for more targeted and effective treatments. To summarize, PHAs open new perspectives in the field of medicine by improving drug delivery and offering ecologically biocompatible solutions for medical devices. The aim of this review is to present the medical and dental applications of PHA, their advantages, disadvantages, and indications.
The Characterization of Natural Resins and a Study of Their Degradation in Interactions with Zinc Oxide Pigment
Authors: Calà Elisa , Croce Alessandro , Cagna Laura , Marangon Andrea , Gatti Giorgio , Aceto Maurizio
Published: November 2024

In the last few years, the role of science in Cultural Heritage has assumed greater significance since diagnostics have become essential for the characterization of artworks. The development of conservation strategies involves growing the study of artworks and the knowledge of the materials used against the degradation plaguing the painted surfaces. This work focuses on the investigation of the degradation processes involving paintings on canvas, in particular delamination and progressive deterioration of the painted surfaces. The main causes of the degradation are attributable to the formation of metal soaps, which originate from the interaction between binders and pigments; as a result, the process leads to the progressive fracturing of the paint film. Using various characterization techniques allowed us to acquire information on the structural and morphological properties of the binder resins and study the binder/pigment interaction during the degradation process to understand the quantity and quality of the acid sites present in the binders and, consequently, the potential reactivity with the cationic part of the pigments. The binders were also analyzed within paint layers in contact with zinc oxide to study the interactions and the possible formation of new species as metal soaps and metal oxalates that can modify the boundary among the painting layers and, consequently, the appearance of the artwork and its artistic value. Modifications after UV and thermal aging processes were observed using Infrared spectroscopy and thermogravimetric analysis. Zinc soap formation was observed after 7 h of a UV aging process and was correlated to the acidity of the resins.
Improving the Mechanical Properties and Microstructure of 12 mol% Ceria-Stabilized Tetragonal Zirconia Polycrystal Ceramics with Low-Content Nd2O3
Authors: Sun Zengqing , Li Xiaoyu , Xing Jinxin , Gan Min , Ji Zhiyun , Lyu Yong
Published: November 2024

In this study, 12 mol% ceria-stabilized tetragonal zirconia polycrystal ceramics with xNd2O3 (where x equals 0, 0.1, 0.2, 0.3, 0.4, 0.5, and 0.7) were synthesized via the solid-state method, and the effects of Nd2O3 doping amounts on the mechanical properties and microstructure were studied. The results show that with an increase in the Nd2O3 doping amount, the grain size of the ceramics was reduced from 2.93 μm to 0.69 μm. The hardness and strength of the ceramics increased significantly, while the fracture toughness decreased. The reduction in fracture toughness was attributed to the reduction in tetragonal grain size, which suppressed the tetragonal–monoclinic phase transformation caused by stress. Additionally, as the content of Nd2O3 increased, the formation of cubic zirconia accelerated, but no second phase was observed. Most importantly, when the doping amount of Nd2O3 reached 0.3 mol%, the comprehensive mechanical characteristics of the ceramics were optimal. This provides a research basis for the preparation of nanoscale 12 mol% ceria-stabilized tetragonal zirconia polycrystal ceramics.
The High-Order ADI Difference Method and Extrapolation Method for Solving the Two-Dimensional Nonlinear Parabolic Evolution Equations
Authors: Shen Xin , Yang Xuehua , Zhang Haixiang
Published: November 2024

In this paper, the numerical solution for two-dimensional nonlinear parabolic equations is studied using an alternating-direction implicit (ADI) Crank–Nicolson (CN) difference scheme. Firstly, we use the CN format in the time direction, and then use the CN format in the space direction before discretizing the second-order center difference quotient. In addition, we strictly prove that the proposed ADI difference scheme has unique solvability and is unconditionally stable and convergent. The extrapolation method is further applied to improve the numerical solution accuracy. Finally, two numerical examples are given to verify our theoretical results.
Crystal Chemistry at Interfaces Between Liquid Al and Polar SiC{0001} Substrates
Authors: Fang Changming , Fan Zhongyun
Published: November 2024

Silicon carbide (SiC) has been widely added into light metals, e.g., Al, to enhance their mechanical performance and corrosion resistance. SiC particle-reinforced metal matrix composites (SiC-MMCs) exhibit low weight/volume ratios, high strength/hardness, high corrosion resistance, and thermal stability. They have potential applications in aerospace, automobiles, and other specialized equipment. The macro-mechanical properties of Al/SiC composites depend on the local structures and chemical interactions at the Al/SiC interfaces at the atomic level. Moreover, the added SiC particles may act as potential nucleation sites during solidification. We investigate local atomic ordering and chemical interactions at the interfaces between liquid Al (Al(l) in short) and polar SiC substrates using ab initio molecular dynamics (AIMD) methods. The simulations reveal a rich variety of interfacial interactions. Charge transfer occurs from Al(l) to C-terminating atoms (Δq = 0.3e/Al on average), while chemical bonding between interfacial Si and Al(l) atoms is more covalent with a minor charge transfer of Δq = 0.04e/Al. The prenucleation at both interfaces is moderate with three to four recognizable layers. The information obtained here helps increase understanding of the interfacial interactions at Al/SiC at the atomic level and the related macro-mechanical properties, which is helpful in designing novel SiC-MMC materials with desirable properties and optimizing related manufacturing and machining processes.
Internally Harmonic Matched Compact GaN Power Amplifier with 78.5% PAE for 2.45 GHz Wireless Power Transfer Systems
Authors: Li Caoyu , Zhang Ziliang , Pei Yi , Chen Changchang , Feng Gang , Xu Yuehang
Published: November 2024

In this paper, a high-efficiency compact power amplifier is designed and fabricated with a 0.25 μm GaN high electron mobility transistor (HEMT) to meet the demands of a high integration level and high efficiency for microwave wireless power transfer (WPT) systems. The proposed power amplifier (PA) is implemented using an internally matched method to achieve a compact circuit size. The output second and third harmonic impedances can be optimized through output matching circuits, eliminating the need for additional harmonic matching networks. This approach simplifies the design of matching circuits and reduces the circuit size. Furthermore, the input third harmonic has been controled for improving the efficiency of DC-to-RF conversion. The total size of the proposed PA is 13.4 × 13.5 mm2. The test results obtained from the continuous wave (CW) testing indicate that the output power of the power amplifier at 2.45 GHz reaches 43.75 dBm. Additionally, the large-signal gain is measured at 15.75 dB, and the power-added efficiency (PAE) achieves a value of 78.5%.
Maternal Dietary Patterns During Pregnancy and Child Autism-Related Traits in the Environmental Influences on Child Health Outcomes Consortium
Authors: Vecchione Rachel , Westlake Matt , Bragg Megan G. , Rando Juliette , Bennett Deborah H. , Croen Lisa A. , Dunlop Anne L. , Ferrara Assiamira , Hedderson Monique M. , Kerver Jean M. , Lee Brian K. , Lin Pi-I D. , Hertz-Picciotto Irva , Schmidt Rebecca J. , Strakovsky Rita S. , Lyall Kristen
Published: November 2024

We examined relationships between prenatal dietary patterns and child autism-related outcomes, including parent-reported clinician diagnoses of autism spectrum disorder (ASD) and Social Responsiveness Scale (SRS-2) scores, in up to 6084 participants (with analytic samples ranging from 1671 to 4128 participants) from 14 cohorts in the Environmental Influences on Child Health Outcomes (ECHO) consortium. Associations between quartiles of the Healthy Eating Index (HEI-2015), the Alternative Healthy Eating Index modified for Pregnancy (AHEI-P), and the Empirical Dietary Inflammatory Pattern (EDIP), calculated based on reported prenatal diet, and outcomes were examined using crude and multivariable regression (quantile for SRS scores and logistic for diagnosis). In adjusted models, the higher quartile of prenatal HEI score was associated with lower SRS scores (Q4 vs. Q1 β for median quantile = −3.41 95% CI = −5.15, −1.26). A similar association was observed for the AHEI-P score when adjusting for total calories (Q4 vs. Q1 β = −2.52 95% −4.59, −0.45). There were no significant associations of prenatal diet with ASD diagnosis. Findings from this large U.S.-based study do not suggest strong associations between prenatal dietary patterns and ASD-related outcomes, although subtle associations with broader traits suggest the need to further consider how prenatal diet may relate to ASD-related phenotypes.
Prevalence and Sociodemographic Risk Factors of Soil-Transmitted Helminths in Rural Communities Living in Endemic Foci of Onchocerciasis in Southern Gabon
Authors: Moutongo Mouandza Reinne , Mourou Mbina Jean Romain , Moutombi Ditombi Bridy , Mihindou Joyce Coella , Moussavou Mabicka Dimitri Ardrin , Mayandza Christian , Mbondoukwe Noe Patrick , Pongui Ngondza Bedrich , Ndong Akomezoghe Luccheri , Mawili Mboumba Denise Patricia , Bouyou Akotet Marielle Karine
Published: November 2024

This prospective survey determined the prevalence and intensity of infections due to geohelminths and the associated risk factors in five onchocerciasis-endemic communities in Gabon between January and February 2020. Onchocerciasis endemicity was confirmed by Ov16 IgG testing. STHs were detected using the Kato–Katz techniques. Prevalence and parasite density were analyzed according to age, sex, and onchocerciasis endemicity. STHs were found in 64.8% of participants and were more common in hypoendemic (80.9%) and hyperendemic (63.9%) onchocerciasis communities (p < 0.01). Ascaris lumbricoides (65.5%), Trichuris trichiura (57.1%), and hookworms (17.3%) were prevalent in areas hypoendemic for onchocerciasis (p = 0.04). Male participants were more often infected by hookworms. Adults were more frequently infected by STHs (75.9%) than elders, who were the least infected (39.3%) (p < 0.01). Participants living in sporadic onchocerciasis areas frequently but not significantly harbored a moderate ascariasis load (6960.0 (1068.0–9492.0) eggs per gram) (p = 0.4). The highest parasite density was observed among participants aged 20–45 years (15,336.0 (3888.0–35,028.0)). A low T. trichiuria prevalence was found in all communities. STHs are highly prevalent in hypoendemic and hyperendemic areas and adults. An integrated combined approach of STH and onchocerciasis elimination through efficacious mass drug administration targeting all age groups should be considered.
In Silico and In Vitro Investigation of Cytotoxicity and Apoptosis of Acridine/Sulfonamide Hybrids Targeting Topoisomerases I and II
Authors: Badr Mohamed , Elmongy Elshaymaa I. , Elkhateeb Doaa , Moemen Yasmine S. , Khalil Ashraf , Ali Hadeer , Binsuwaidan Reem , Awadallah Feby , El Sayed Ibrahim El Tantawy
Published: November 2024

Background: Sulfonamide acridine derivatives have garnered significant attention from medicinal chemists due to their diverse range of biological activities. Methods: In this study, eleven compounds were synthesized according to the literature, and their impact on cell growth inhibition, induction of apoptosis, and cell cycle distribution were assessed in three different cell lines. Their inhibitory effects on the topoisomerase (Topo) I and II were investigated in vitro. Molecular docking studies were conducted to predict the binding affinities of these compounds for crystallized downloaded topoisomerases. Results: The compounds were examined in vitro for their anticancer activity against human hepatic (HepG2) colon (HCT-8) and breast (MCF-7) carcinoma cell lines. Compound 8b was the most active against HepG2, HCT-116, and MCF-7 with IC50 14.51, 9.39, and 8.83 µM, respectively, compared to Doxorubicin as reference. In addition, it demonstrated the highest potency among the tested compounds against Topo-I, with an IC50 value of 3.41 µg/mL compared to the control camptothecin (IC50 of 1.46 μM). Compound 7c displayed a significant inhibitory effect on Topo-II, with an IC50 of 7.33 μM, compared to an IC50 value of 6.49 μM via Doxorubicin, the control. Compounds 7c and 8b were assessed against topoisomerases showing induction of apoptosis and a reduction in the S phase of the cell cycle. Molecular docking demonstrated interaction with the active site as with those exhibited by the co-crystallized ligands of the crystallized proteins in both topoisomerases. Conclusion: Compounds 7c and 8b hold promise as potential anticancer drugs due to their anti-proliferative and proapoptotic effects, which are mediated by their action on the topoisomerase enzyme, particularly Topo II.
Recent Advances in Simulation Studies on the Protein Corona
Authors: Lee Hwankyu
Published: November 2024

When flowing through the blood stream, drug carriers such as nanoparticles encounter hundreds of plasma proteins, forming a protein layer on the nanoparticle surface, known as the “protein corona”. Since the protein corona influences the size, shape, and surface properties of nanoparticles, it can modulate their circulating lifetime, cytotoxicity, and targeting efficiency. Therefore, understanding the mechanism of protein corona formation at the atomic scale is crucial, which has become possible due to advances in computer power and simulation methodologies. This review covers the following topics: (1) the structure, dynamics, and composition of protein corona on nanoparticles; (2) the effects of protein concentration and ionic strength on protein corona formation; (3) the effects of particle size, morphology, and surface properties on corona formation; (4) the interactions among lipids, membranes, and nanoparticles with the protein corona. For each topic, mesoscale, coarse-grained, and all-atom molecular dynamics simulations since 2020 are discussed. These simulations not only successfully reproduce experimental observations but also provide physical insights into the protein corona formation. In particular, these simulation findings can be applied to manipulate the formation of a protein corona that can target specific cells, aiding in the rational design of nanomedicines for drug delivery applications.
Metal Resistance of Microorganisms as a Crucial Factor for Their Homeostasis and Sustainable Environment
Authors: Hovorukha Vira , Moliszewska Ewa , Havryliuk Olesia , Bida Iryna , Tashyrev Oleksandr
Published: November 2024

Heavy metals are prevalent environmental components, but when their concentrations exceed critical thresholds, they pose environmental hazards, disrupting the sustainability of ecosystems. Microorganisms are among the first to encounter the toxic effects of metals. Therefore, it is crucial to understand both the levels and mechanisms of their resistance to maintain their homeostasis under the pressure of extreme factors as well as contribute to increasing the sustainability of ecosystems. The aim of the study was to examine two soil bacterial strains, Brevundimonas vesicularis USM1 and Pseudomonas putida USM4, to assess their resistance levels to toxic metals and to identify the mechanisms behind this resistance. For this purpose, microbiological, statistical, and bioinformatics methods were used. The comparative analysis of the two strains revealed that P. putida USM4 exhibited greater resistance to Cr(VI), Co(II), Cu(II), Ni(II), and Fe(III) compared to B. vesicularis USM1. This was confirmed by the metal concentrations at which the strains could survive, their growth dynamics, and the genetically based resistance mechanisms. These findings enhance our understanding of microbial metal resistance and contribute to the advancement of microbial-based environmental biotechnologies.
Dewatering and Transport in Sustainable Sediment Management: A Review
Authors: Levacher Daniel , Boullosa Allariz Beatriz , Hussan Ali
Published: November 2024

This paper deals with the dewatering and handling of dredged sediments in the context of sustainability and renewability of natural resources. Dewatering is a critical part of sediment management, as the high water content of dredged sediments becomes a challenge for transportation, final storage and/or recycling. This is why it is necessary to reduce their water content before transportation. Conventional methods suggest using land-based drained basins, which is a sustainable solution. However, this solution has certain drawbacks: dewatering the sediment is time-consuming and involves the use of large land areas. The main problem with this method of dewatering can be solved by proposing mechanical dewatering in the vicinity of the dredging operation. Once the sediment has been sufficiently dewatered, it should be shoveled and transported again. The proposed paper covers the study of the dewatering and shoveling ability of sediments. After introducing why dewatering is a critical phase in the recycling process of sediment, some techniques for dewatering large volumes of high-water sediments are briefly reported. Typical dewatering laboratory tests are detailed, demonstrating their usefulness for understanding the mechanisms of natural dewatering. A laboratory dewatering press machine is reported and the procedure used for a sediment sludge. The last section concerns a recent innovative test implemented for the study of the shoveling ability and adhesion of sediments. This study improves our understanding of the phenomenon of sediment dewatering, for both natural and mechanical dewatering. It also provides the protocols for typical laboratory tests on sediment dewatering and shoveling ability.
Energy Citizenship in Energy Transition: The Case of the Baltic States
Authors: Ikstena Rasa , Lagzdiņa Ērika , Brizga Jānis , Kudrenickis Ivars , Ernšteins Raimonds
Published: November 2024

The governance of energy systems is undergoing a transformative shift, vital to advancing the energy transition. Understanding the dynamics of energy citizenship and the factors that influence citizen engagement in energy matters is critical for driving social and institutional change. This paper informs on the key results of a comprehensive analysis of 54 energy citizenship cases in the Baltic states (Latvia, Estonia, and Lithuania). The study explores the role of citizens in the energy transition and characterizes the socio-economic and geopolitical factors shaping energy citizenship activities in the region. The governance of energy systems represents a significant transformational shift that is essential for energy transition. A more comprehensive understanding of the current state of energy citizenship and the factors influencing the energy transition process could inform the social and institutional changes necessary for the involvement of citizens in energy matters. This desk study represents a crucial element of the EU Horizon 2000 EnergyPROSPECTS project, which aims to map the landscape of energy citizenship in Europe. This paper presents an in-depth analysis of 54 cases from the Baltic states. The findings provide insight into the role of citizens in the transition process and the underlying factors and conditions that shape energy citizenship activities within the specific socio-economic and geopolitical context of the region. In general, energy citizenship in the Baltic states can be seen to exist on a spectrum between reformative and transformative practices. Overall, progress is being made toward systemic changes in the energy sector, with a focus on the democratization of processes. Nevertheless, additional measures to enhance and reinforce energy citizenship, coupled with the advancement of enabling conditions, are imperative at all levels of governance and across all energy transition scenarios.
From Sustainable Agriculture to Sustainable Agrifood Systems: A Comparative Review of Alternative Models
Authors: Zhang Qian Forrest
Published: November 2024

This paper reviews, compares, and critically evaluates two broad groups of sustainable agriculture models: “sustainable agriculture” and “sustainable agrifood systems”. The “sustainable agriculture” models—comprising organic farming, regenerative agriculture, climate-smart agriculture, carbon-capture agriculture, and nature-based solutions—focus primarily on improving ecological sustainability through farm-level practices. These models emphasize reducing external, industrial inputs, enhancing biodiversity, and promoting climate resilience, relying on technological and market-based solutions to address environmental concerns. On the other hand, the “sustainable agrifood systems” models—agroecology, alternative food networks, and permaculture—offer more ambitious visions of systemic transformation. These approaches not only seek to implement environmentally sound practices but also aim to reconfigure the broader food system by challenging corporate power, promoting local governance, fostering food sovereignty, and prioritizing social justice. Grounded in grassroots movements, these models emphasize social justice and economic viability in addition to ecological sustainability. This paper’s contribution lies in its comparative analysis of the wide array of sustainable alternatives, highlighting both their strengths and limitations. Adopting an agrarian political economy perspective, it critiques the former camp for limited engagement with structural issues inherent in capitalist agriculture and the latter camp for underplaying the importance of industrial agriculture for national development in the Global South.
Digital Economy, Marine Industrial Structure Upgrading, and the High-Quality Development of Marine Economy Based on the Static and Dynamic Spatial Durbin Model
Authors: Zhang Ying , Li Xuemei
Published: November 2024

Achieving marine sustainable development goals requires improving the quality of the marine economy. In this study, we constructed a multi-dimensional evaluation index system to quantify the high-quality development of the marine economy (HDME) and digital economy for China’s 11 coastal regions between 2012 and 2020, and systematically explored the mechanisms between the digital economy, marine industrial structure upgrading, and high-quality development of the marine economy. We further empirically analyzed the influence of the digital economy and marine industrial structure upgrading on the HDME by using the static and dynamic spatial Durbin model and threshold model. We found that the digital economy improved the HDME of local and neighboring regions, and the sub-dimensional indicators had a significant heterogeneous effect. The marine industrial structure upgrading only positively affected the quality of the marine economy in neighboring areas. Furthermore, the digital economy and marine industrial structure upgrading also had synergistic effects on improving the marine economy, which mainly depended on digital infrastructure and digital industrialization. There also existed digital infrastructure and digital industrialization thresholds within marine industrial structure upgrading, affecting the HDME. Our results provide new insights for the green and sustainable development of the marine industry and marine economy from a broader technical perspective in the digital age. Governments should recognize the spatial spillover and synergistic effects of the digital economy and marine industrial structure between different regions and implement policies considering their impacts to achieve the marine sustainable development goals.
Drainage Pipeline Defect Detection System Based on Semantic Segmentation
Authors: Du Chun , Wang Kunpeng
Published: November 2024

Since drainage pipes are widely used in daily life and are necessary for cities to function normally, intelligent fault detection in these pipes has emerged as both an urgent necessity and a major area of development. Compared to traditional target detection methods, the semantic segmentation-based pipeline defect detection method has some special qualities. It can effectively detect a variety of pipeline defect types and segment the defects using precise geometrical attributes to support subsequent defect assessment. This study replaces the backbone network and fuses bar pooling and cascade feature fusion modules in the encoding and decoding phases, respectively, to obtain richer semantic information. This approach strikes a balance between segmentation accuracy and model complexity, aiming to address the problems of the large computational volume of semantic segmentation and the loss of detailed semantic information of pipeline defects. In the pipe defect dataset, the proposed approach is compared with the baseline algorithm and the experimental findings indicate that it has a greater segmentation accuracy than the conventional algorithm. Additionally, the lightweight design of the algorithm lowers the model’s complexity.
On the Analytic Continuation of Appell’s Hypergeometric Function F2 to Some Symmetric Domains in the Space C2
Authors: Dmytryshyn Roman
Published: November 2024

The paper considers the problem of representation and extension of Appell’s hypergeometric functions by a special family of functions—branched continued fractions. Here, we establish new symmetric domains of the analytical continuation of Appell’s hypergeometric function F2 with real and complex parameters, using their branched continued fraction expansions whose elements are polynomials in the space C2. To do this, we used a technique that extends the domain of convergence of the branched continued fraction, which is already known for a small domain, to a larger domain, as well as the PC method to prove that it is also the domain of analytical continuation. A few examples are provided at the end to illustrate this.
Extraordinary Nature of the Nucleon Scalar Charge and Its Densities as a Signal of Nontrivial Vacuum Structure of QCD
Authors: Wakamatsu Masashi
Published: November 2024

It is widely known that the nucleon scalar charge is proportional to the pion–nucleon sigma term as one of the important low-energy observables of QCD. Especially interesting to us is the physics of the nucleon scalar charge densities. This comes from the fact that the corresponding operator has the same quantum number as the physical vacuum. It indicates unusual behavior of the nucleon scalar density as a function of the distance r from the nucleon center. Namely, it would not be reduced down to zero at the spatial infinity but rather approach some nonzero constant corresponding to the vacuum quark condensate. Naturally, this unique nature of the nucleon scalar density in the position space also affects the corresponding density in the momentum space, i.e., the corresponding parton distribution function (PDF) as a function of the Bjorken variable x. This PDF is known as the chiral-odd twist-3 PDF e(x). We argue that e(x) is likely to have a delta-function-type singularity at x=0 and that the appearance of this singularity can be interpreted as a signal of the nontrivial vacuum structure of QCD.
Phason and Amplitudon Modes in K3Na(SeO4)2 Crystal
Authors: Kaczmarski Marceli , Jenczyk Jacek , Mróz Bogusław
Published: November 2024

For the first time, the Nambu–Goldstone optical mode has been observed in ferroelastic crystals. The amplitudon and phason modes were identified in the Raman spectra of the K3Na(SeO4)2 (KNSe) crystal. We discuss the occurrence of such lattice vibration with regard to the possible presence of an incommensurate (IC) phase. The potential scenario of the dynamics of the SO4 tetrahedron leading to the appearance of an IC phase, accompanied by critical temperature behavior of two external vibrations of Ag symmetry, is given together with the molecular mechanism of the phase transitions in the material studied. The effect of the spatial reorganization of the crystal lattice associated with the ferroelastic domains of the KNSe crystal of W and W′ types is also discussed. We show that the emergence of such a domain structure may also be a source of incommensurability.
Influenza Vaccination Coverage and Influencing Factors in Type 2 Diabetes in Mainland China: A Systematic Review and Meta-Analysis
Authors: Yang Cheng , Liu Shijun , Xu Jue , Fu Wen , Qiu Xin , Jiang Caixia
Published: November 2024

Background: Influenza has many harmful effects on people with type 2 diabetes mellitus (T2DM), such as hyperglycemia and increasing incidence of cardiovascular and cerebrovascular diseases. Epidemiological evidence shows that influenza vaccinations can effectively prevent deterioration in T2DM patients. At present, there is a lack of nationwide studies on the vaccination status of influenza vaccines for patients with certain chronic diseases. This study aimed to evaluate the influenza vaccination status of T2DM patients in mainland China and the factors affecting their influenza vaccination. Methods: Data were sourced from PubMed, Embase, Web of Science, the China Biology Medicine Disc (CBMdisc), the China National Knowledge Infrastructure (CNKI), and the Wanfang Database. The keywords used in the literature search included “diabetes”, “diabetes mellitus”, “DM”, “diabetic”, “T2DM”, “influenza vaccine”, “flu vaccine”, “China”, and “Chinese”. A total of 249 articles were retrieved through the searches; 7 articles met the inclusion criteria. The fixed-effects model was used when heterogeneity was low and a random-effects model was used when the heterogeneity was high. Results: The influenza vaccination coverage rate was 1.46% in diabetic patients and 9.99% in elderly diabetic patients. The influenza vaccination rate of type 2 diabetes patients with a high education level is higher than that of patients with a low education level. (OR: 1.462 [1.123, 1.903]). Meanwhile, gender (OR: 1.076, 95%CI: 0.893–1.295), marriage (OR: 1.283; 95%CI: 0.931–1.766), and occupation (OR: 1.049; 95% CI: 4.422–2.606) have no significant impact on influenza vaccination in patients with type 2 diabetes. Conclusions: This study found that the coverage of influenza vaccination in patients with T2DM in Chinese mainland was low, and there were few relevant research articles. In China’s mainland areas, education background is an important factor affecting the influenza vaccination of T2DM patients. China should continue to improve the influenza vaccination rate of patients with type 2 diabetes.
Hydrological Simulation and Parameter Optimization Based on the Distributed Xin’anjiang Model and the Particle Swarm Optimization Algorithm: A Case Study of Xunhe Watershed in Shandong, China
Authors: Wang Zihao , Zhang Xiaoxiang , Liu Changjun , Ren Liliang , Cai Xi , Li Kuang
Published: November 2024

Hydrological models serve as essential tools in hydrological research, allowing us to address practical hydrological issues. This study focuses on the Xunhe Watershed in Shandong Province, China, constructing a distributed Xin’anjiang hydrological model. Furthermore, traditional manual calibration and automatic calibration using the Particle Swarm Optimization (PSO) algorithm were employed to determine model parameters, followed by hydrological simulations, with the aim of investigating the applicability of the distributed Xin’anjiang model in this watershed. The research findings indicate that the distributed Xin’anjiang model accurately simulates the hydrological processes in the Xunhe Watershed. There is a high level of agreement between the observed data and the simulated results, including key indicators such as peak discharge, runoff volume, and peak time. After optimizing the model parameters using the PSO algorithm, the distributed Xin’anjiang model demonstrates improved simulation performance in the Xunhe Watershed. During the calibration period, the mean relative peak discharge error (RPE) is 4.1%, the mean relative runoff error (RRE) is 4.34%, and the average Nash–Sutcliffe efficiency (NSE) for simulating the flood events is 0.89. During the validation period, the mean RPE is 3.82%, the mean RRE is 6.1%, and the average NSE for the process is 0.83. This indicates that the distributed Xin’anjiang model has good applicability in this watershed, providing a reliable reference for flood control and disaster reduction in the Xunhe Watershed.