bluuebunny/crossref_metadata_2025 huggingface dataset:
KLF4K409Q–mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment
Authors: von Spreckelsen Niklas , Waldt Natalie , Poetschke Rebecca , Kesseler Christoph , Dohmen Hildegard , Jiao Hui-Ke , Nemeth Attila , Schob Stefan , Scherlach Cordula , Sandalcioglu Ibrahim Erol , Deckert Martina , Angenstein Frank , Krischek Boris , Stavrinou Pantelis , Timmer Marco , Remke Marc , Kirches Elmar , Goldbrunner Roland , Chiocca E. Antonio , Huettelmaier Stefan , Acker Till , Mawrin Christian
Published: April 2020

Meningioma represents the most common primary brain tumor in adults. Recently several non-NF2 mutations in meningioma have been identified and correlated with certain pathological subtypes, locations and clinical observations. Alterations of cellular pathways due to these mutations, however, have largely remained elusive. Here we report that the Krueppel like factor 4 (KLF4)-K409Q mutation in skull base meningiomas triggers a distinct tumor phenotype. Transcriptomic analysis of 17 meningioma samples revealed that KLF4K409Q mutated tumors harbor an upregulation of hypoxia dependent pathways. Detailed in vitro investigation further showed that the KLF4K409Q mutation induces HIF-1α through the reduction of prolyl hydroxylase activity and causes an upregulation of downstream HIF-1α targets. Finally, we demonstrate that KLF4K409Q mutated tumors are susceptible to mTOR inhibition by Temsirolimus. Taken together, our data link the KLF4K409Q mediated upregulation of HIF pathways to the clinical and biological characteristics of these skull base meningiomas possibly opening new therapeutic avenues for this distinct meningioma subtype.
Submarine landslide source models consistent with multiple tsunami records of the 2018 Palu tsunami, Sulawesi, Indonesia
Authors: Nakata Kenji , Katsumata Akio , Muhari Abdul
Published: April 2020

Previous studies have suggested submarine landslides as sources of the tsunami that damaged coastal areas of Palu Bay after the 2018 Sulawesi earthquake. Indeed, tsunami run-up heights as high as 10 m determined by field surveys cannot be explained by the earthquake source alone although the earthquake is definitely the primary cause of the tsunami. The quantitatively re-examined results using the earthquake fault models reported so far showed that none of them could fully explain the observed tsunami data: tsunami waveforms inferred from video footage and the field survey run-up tsunami height distribution. Here, we present probable tsunami source models including submarine landslides that are consistent with the observed tsunami data. We simulated tsunamis generated by submarine landslides using a simplified depth-averaged two-dimensional model. The estimated submarine landslide model consisted of two sources in the northern and southern parts of the bay, and it explained the observed tsunami data well. Their volumes were 0.02 and 0.07 km3. The radius of the major axis and the maximum thickness of the initial paraboloid masses and the maximum horizontal velocity of the masses were 0.8 km, 40 m and 21 m/s in the northern bay, and 2.0 km, 15 m and 19 m/s in the southern bay, respectively. The landslide source in the northern bay needed to start to move about 70 s after the earthquake to match the calculated and observed arrival times.
The effect of alumina powder in dielectric on electrical discharge machining parameters of aluminum composite A413-Al2O3 by the Taguchi method, the signal-to-noise analysis and the total normalized quality loss
Authors: Shahbazi Dastjerdi Mojtaba , Mokhtarian Ali , Saraeian Payam
Published: April 2020

The machining capability of metal composites is different compared to other materials because of their specific physical and mechanical properties. The aluminum composite A413 reinforced with Alumina powder is one of the materials which causes rapid erosion of the tool if traditional machining methods are employed. In this research, the electrical discharge machining experiments were conducted using the Taguchi method. After analysis of variance (ANOVA) using simultaneous analysis of total normalized quality loss (TNQL), and signal-to-noise ratio (S/N) of outputs, the effect of each parameter such as current intensity, voltage, pulse on-time and pulse off-time have been investigated. These parameters are influential on material removal rates, surface roughness, and tool wear ratio of electric discharge machining in two cases of with alumina powder and without alumina powder in dielectric. The outcomes of this research indicate that the use of Alumina powder 3 g/L in kerosene dielectric averagely reduces the material removal rate by 7.8%, increases the surface roughness by 8.8%, and decreases the tool wear ratio by 1.3%. Also, the results of analysis of total normalized quality loss and signal-to-noise ratio of the experiment have been shown as the first level of voltage (A1), the first level of current intensity (B1), the first level of pulse on time (C1), and the third level of pulse off time (D3).
Emergency intensive care unit pharmacist’s intervention may reduce time to four-factor prothrombin complex concentrate administration: a retrospective study
Authors: Imanaka Shoichi , Kuwabara Tatsuro , Ikeda Hiroto , Miyake Yasufumi , Enomoto Hiromi , Sakamoto Tetsuya , Yasuno Nobuhiro
Published: April 2020

Background

Four-factor prothrombin complex concentrate (4F-PCC) must be administered as soon as possible, and in our emergency intensive care unit (EICU), pharmacists are available on weekdays for consultation on expediting 4F-PCC administration. Although recent reports have described a reduction in time to 4F-PCC administration, few studies have addressed if this is because of EICU pharmacist’s intervention, and there are no such studies in Japan. Therefore, we aimed to examine whether EICU pharmacist’s intervention reduced time to 4F-PCC administration.

Methods

This single-center retrospective cohort study was conducted from December 2017 to May 2019. We enrolled patients who received 4F-PCC due to major bleeding or requirement of urgent surgical/invasive procedures (n = 10). Patients were divided into two groups, namely, the intervention group (n = 5), in which EICU pharmacists consulted on weekdays, and the nonintervention group (n = 5), in which an intervention was not possible because of the absence of the EICU pharmacist.

Results

The median time from patient presentation to the EICU to 4F-PCC administration (103 min vs. 111 min, p = 0.4) was similar between the two groups; however, the median time from 4F-PCC prescription ordering to administration was significantly shorter in the intervention group than in the nonintervention group (21 min vs. 60 min, p = 0.02).

Conclusions

EICU pharmacist’s intervention improves the process from 4F-PCC prescription to administration and can reduce time to 4F-PCC administration.
Effective exchange to a larger size catheter for a lung abscess with initial percutaneous drainage failure: a case report
Authors: Oh Maki , Mori Shohei , Noda Yuki , Kato Daiki , Ohtsuka Takashi
Published: April 2020

Background

Percutaneous catheter drainage is an effective therapy for antibiotic-refractory lung abscesses. Pulmonary resection is usually considered in cases of drainage failure, although it remains controversial.

Case presentation

A 42-year-old man with antibiotic-refractory lung abscess underwent percutaneous abscess drainage with a 10-Fr pigtail catheter. However, adequate evacuation of the abscess content was not achieved, and his respiratory condition worsened and he required a ventilator. To achieve and maintain effective drainage, insertion of a larger size 28-Fr catheter to replace the 10-Fr catheter was performed under general anesthesia and one-lung ventilation with a double-lumen tube to isolate the left lung. Exchange with a larger size catheter was effective and achieved adequate drainage. The procedure was performed safely by expanding the route of the old catheter as a guide for accessing the abscess cavity. His condition immediately improved and he was discharged on day 40 post-catheter exchange with no complications and cured with a small residual thin wall cavity.

Conclusions

Small size catheters are generally recommended for initial percutaneous drainage; however, we argue that exchange with larger size catheters should be primarily considered instead of pulmonary resection in cases of initial drainage failure. This may avoid the need for pulmonary resection.
The potential for computational IT tools in disaster relief and shelter design
Authors: Kuchai Noorullah , Shepherd Paul , Calabria-Holley Juliana , Copping Alexander , Matard Aude , Coley David
Published: April 2020

The expanding use of IT has brought an increase in productivity to the world of business, industry and commerce. However, this is not mirrored by an equivalent growth in the use of IT by aid agencies in post-disaster situations. We report a pioneering two-stage study which tested the appetite for the increased use of computational IT tools in this sector, assessed their level of usefulness and whether they can be practically implemented. Thirty aid workers across nineteen countries were surveyed on their use of IT and computational tools in shelter design and provision. The key finding was that none of the participants used any building simulation tools or software packages in any of the design stages of shelter construction. Using this result, two example tools were created—one assessing daylighting and the other environmental impact. A second survey involving 48 aid workers was then carried out to record their experience of using the new tools and 97% of the participants identified a need for such shelter design tools. The majority felt that the new tools were useful and that they would like to use similar tools in their work, most of them preferring tools in the form of web applications. It is concluded that humanitarian workers in the shelter sector are very willing to adopt IT-based computational tools in their work and would appreciate doing so, but only if they have access to suitably simple tools which are quick to use and easy to learn.
The HCR-20 and violence risk assessment – will a peak of inflated expectations turn to a trough of disillusionment?
Authors: Silva Edward
Published: April 2020

The HCR-20 has taken on a life of its own. In forensic services it has been elevated from helpful aide-mémoire into a prophetic tool worthy of Nostradamus himself. Almost every outcome is interpreted through it. Despite the evidence of its limited utility, the difficulties of predicting rare events, the narrative fallacies and other heuristic biases it creates, and the massive opportunity costs it entails, commissioners and services alike mandate its use. Yet in routine practice the problems are not acknowledged, multiple conflicts of interest lie unobserved and other opportunities are neglected.
Preconditioning strategies to prevent acute kidney injury
Authors: Späth Martin Richard , Koehler Felix Carlo , Hoyer-Allo Karla Johanna Ruth , Grundmann Franziska , Burst Volker , Müller Roman-Ulrich
Published: April 2020

Acute kidney injury is a common clinical disorder resulting in significantly increased morbidity and mortality. However, despite extensive research, strategies for prevention or treatment are still lacking in routine clinical practice.

Already decades ago, several preconditioning strategies (e. g. ischemic/hypoxic preconditioning and calorie restriction) have been published and their extraordinary effectiveness - especially in rodents - has raised the hope for powerful clinical tools to prevent acute kidney injury. However, the underlying mechanisms are still not completely understood and translation to the clinics has not been successful yet. In this review, the most attractive strategies and the current mechanistic concepts are introduced and discussed. Furthermore, we present clinical trials evaluating the feasibility of preconditioning in the clinical setting.
Do otimismo à agressão: cognições positivas preveem comportamento violento em homens
Authors: Cabral João Carlos Centurion , Corrêa Mikael Almeida , Das Neves Vera Torres , Dias Ana Cristina Garcia , De Almeida Rosa Maria Martins
Published: April 2020

As pessoas costumam ter expectativas excessivamente otimistas sobre si mesmas e sobre o futuro. As cognições e emoções negativas têm efeitos diretos sobre o comportamento agressivo; contudo, são escassos os estudos que consideraram a relevância das cognições positivas, como a autoconfiança e o otimismo. Neste estudo, buscamos avaliar se o viés de otimismo, a percepção positiva de habilidades pessoais e a autoconfiança preveem a ocorrência de agressão em homens. Verificamos também se a testosterona e o cortisol são mediadores da relação entre as cognições positivas e a agressão. Nossos resultados indicam que o viés de otimismo e a autoconfiança são preditores significativos de agressão. Embora os hormônios esteroides tenham previsto a ocorrência das cognições positivas, nenhuma medida hormonal mediou a relação do otimismo ou da autoconfiança com a agressão. As cognições positivas e, principalmente, o viés de otimismo podem ter um papel relevante para a agressividade masculina, possivelmente através da redução do controle de impulsos, aumentando, portanto, os comportamentos de risco.
O PROCESSO DE URBANIZAÇÃO E A CONFIGURAÇÃO DO ESPAÇO URBANO DE CAETITÉ-BA
Authors: Neves de Jesus Sandra Lician Sacramento
Published: April 2020

Compreender a formação e usos do espaço da cidade pequena é um desafio para a Geografia Urbana, pois, no contexto atual da urbanização, a configuração desse espaço torna-se muito complexa, pois dialetiza-se internamente, ao criar sua distinção e papel frente as dentre as demais categorias analíticas. O presente artigo tem como objetivo apresentar a urbanização pretérita e atual e a configuração da cidade pequena de Caetité. A metodologia canalizou pesquisas documentais e a análise de dados bibliográficos. A urbanização não é apenas a concentração populacional nas cidades, pois a sociedade criou a inter-relação e/ou distanciamento entre os lugares, o que mudou as relações interpessoais, sociais e direcionou o fenômeno para além do simples fato de um grupo de pessoas se deslocar e concentrar para formar a cidade. Nesse ínterim, não se pode confundi-la com o êxodo rural e seus resultados, que causam nas cidades o efeito do crescimento desordenado. É uma dinâmica social de reformulação da própria sociedade que se transforma continuamente e muda as suas relações com a natureza com base nas necessidades da circulação do capital. No caso de Caetité, é decorrente de processos históricos ligados a colonização. Destacam-se suas fases: pretérita e a atual como imprescindíveis na composição político-sócioespacial.
URBANIZAÇÃO EM CIDADES PEQUENAS: O CASO DE NOVA CANAÃ/BA
Authors: Santana Ítalo Costa Vaz
Published: April 2020

Este artigo tem como objetivo central estudar o processo de produção histórica da cidade de Nova Canaã/BA, levantando a discussão sobre urbanização como processo e a influência desse nas cidades pequenas. A metodologia empregada concentrou-se em leituras bibliográficas acerca do tema proposto, pesquisa documental em órgãos públicos, arquivos pessoais e nas entrevistas diretas com moradores da cidade. O espaço geográfico está em constante movimento e alteração, com o urbano não é diferente. A urbanização deve ser entendida como um processo que acontece gradativamente e contribui com as alterações das cidades ao longo dos anos, criando e reconstruindo novos espaços. Pensar na urbanização é considerar que, tanto as grandes, como as médias e pequenas cidades estão incluídas nesse processo, ainda que de forma diferente. Pode-se afirmar que a construção da cidade de Nova Canaã, apesar de ter sido, em grande parte, incomum às demais cidades, por ser fundamentada na educação, teve um processo lento em relação a outras cidades do estado. A economia, nas primeiras décadas, estava centralizada principalmente na produção agropecuária, o que ocorreu uma inversão no ano de 1999, quando o setor terciário passou a ser o principal motor da economia municipal.
Alteraciones asociadas al autismo: ¿Qué nos enseñan sobre cómo los bebés adquieren el léxico?
Authors: Belinchón Carmona Mercedes
Published: April 2020

Els nens que reben diagnòstics de trastorns de l’espectre de l’autisme (TEA) mostren trajectòries de desenvolupament lingüístic atípiques, sobretot en els seus primers 2-3 anys de vida. En aquest article, veurem com en aquests nens s’alteren qualitativament precursors i mecanismes essencials per a aquest desenvolupament, i també com nous mètodes d’investigació estan aportant dades que demanen canvis profunds en la manera d’abordar teòricament l’estudi dels mecanismes que fan possible als nens l’accés al món de les paraules.
Reseña de Xeomorfoloxía e paisaxes xeográficas, catro décacas de investigación e ensino: homenaxe a Augusto Pérez Alberti
Authors: Roig-Munar Francesc Xavier
Published: April 2020

Fruto de su jubilación como profesor, y no como investigador, el Dr. Ramón Chao, profesor de la Univ. De Santiago, ha reunido a más de cincuenta colegas para crear el libro Xeomorfoloxía e paisaxes xeográficas, catro décacas de investigación e ensino homenaxe a Augusto Pérez Alberti, que recoge las principales disciplinas y líneas de investigación a través de las cuales, a lo largo de su larga i dilatada carrera, Augusto ha trabajado. Como son la geomorfología, con especial atención a la geomorfología costera, la geomorfología glaciar y periglacial, la hidrología, el estudio del paisaje, el paleoambiente y la planificación territorial, sin menospreciar su gran actividad como divulgador.
Outcomes of patients undergoing radiation therapy for bladder cancer
Authors: Hasan Salman , Galvan Eva Mercedes , Shaver Courtney , Hermans Michael , Ha Chul Soo , Swanson Gregory P.
Published: April 2020

Objectives: To review our two institutional experiences regarding the historical referral patterns of bladder cancer patients to receive radiation therapy, characteristics of these referred patients, and their treatment outcomes.
Methods: A retrospective review was performed analyzing patients who underwent radiation therapy for bladder cancer from 2005 to 2015 (n = 69) at two regional referral institutions. The age-adjusted Charlson comorbidity index (AACCI) was calculated for each patient. Patients were divided into three groups: definitive concurrent chemoradiation (CCR), aggressive radiation (AR) alone ≥ 50 Gy, or palliative radiation alone (PR) < 50 Gy. Gastrointestinal (GI) and genitourinary (GU) acute toxicities were recorded.
Results: The median overall AACCI score was 7, which correlates to a two-year expected survival of 55% ± 11%. Thirty-five (50.7%) patients received CCR, 19 (27.5%) received AR, and 15 (21.7%) received PR. Patients presented with hematuria (n = 43, 62%), pain (n = 18, 26%), or obstruction (n = 12, 17%). Of symptomatic patients, treatment improved hematuria in 86%, pain in 75%, and obstruction in 42%. Twenty-two recurrences (32%) were identified at follow-up. Local, regional, and distant recurrences developed in 20%, 14%, and 17% of patients who received CCR. There were two grade 3 GU toxicities and one grade 3 GI toxicity; all grade 3 toxicities were in patients receiving CCR.
Conclusions: Bladder preservation is possible with chemoradiation therapy; however, urologists rarely refer patients for consideration of chemoradiation. The limited patients who are referred for radiation generally have limited life expectancy, significant comorbidities, or have advanced disease amenable only to palliation. Palliative radiation improves symptoms with minimal toxicity.
Malignant transformation of inflammatory myofibroblastic tumor of urinary bladder: A rare case scenario
Authors: Inamdar Arati A. , Pulinthanathu Rajiv
Published: April 2020

Inflammatory myofibroblastic tumor (IMT) previously known as inflammatory pseudotumor, plasma cell granuloma, pseudosarcoma, myxoid hamartoma or inflammatory myofibrohistiocytic proliferation is recently recognized by World Health Organization (WHO) as “IMT” and is considered as a rare benign tumor of soft tissues occurring commonly in lung, liver and mesentry and omentum. IMT is mainly identified as a lesion of children and young population. In this report, we describe a rare case of IMT occurring in a 93-year-old female in urinary bladder with initial benign presentation but demonstrating rapid malignant transformation as confirmed with morphology and immunohistochemical (IHC) stains. Our report highlights the importance of close follow for IMT showing malignant transformation along with utility of IHC stains to evaluate the degree of malignant transformation in such cases.
Biomarker discovery and beyond for diagnosis of bladder diseases
Authors: Jung Sungyong , Kim Jayoung
Published: April 2020

Molecular biosignatures of altered cellular landscapes and functions have been casually linked with pathological conditions, which imply the promise of biomarkers specific to bladder diseases, such as bladder cancer and other dysfunctions. Urinary biomarkers are particularly attractive due to costs, time, and the minimal and noninvasive efforts acquiring urine. The evolution of omics platforms and bioinformatics for analyzing the genome, epigenome, transcriptome, proteome, lipidome, metabolome, etc., have enabled us to develop more sensitive and disease-specific biomarkers. These discoveries broaden our understanding of the complex biology and pathophysiology of bladder diseases, which can ultimately be translated into the clinical setting. In this short review, we will discuss current efforts on identification of promising urinary biomarkers of bladder diseases and their roles in diagnosis and monitoring. With these considerations, we also aim to provide a prospective view of how we can further utilize these bladder biomarkers in developing ideal and smart medical devices that would be applied in the clinic.
A standardized methodology for longitudinal assessment of corneal endothelial morphometry in eye banked corneas
Authors: Lužnik Zala , Sun Zhongmou , Yin Jia , Benetz Beth Ann , H. Lass Jonathan , Dana Reza
Published: April 2020

Eye banked research-grade human donor corneas serve as principal ex vivo source for studying the mechanisms that underlie corneal endothelial cell damage/death and survival. Wide-field specular microscopy can be used for corneal endothelial visualization and allows for indirect assessment of endothelial cell function by analyzing endothelial cell density and morphometric parameters. However, a standardized approach is needed to observe corneal endothelial changes over time. This protocol describes reliable ex vivo methods for consecutive analyses of human donor corneal endothelial cell density and morphometric parameters change using a wide-field dual imaging specular microscope. This protocol involves tissue warming, acquisition and analysis of specular endothelial images, assessment of corneal layers with the new Enhance mode, optical pachymetry measurement, and qualitative image quality grading scales. This quantitative and qualitative evaluation of donor corneas allows for a systematic analysis of endothelial dynamic responses to ex vivo induced stress and can be used as a valuable tool to better elucidate specular findings and mechanisms mediating corneal endothelial cell loss in corneal disease and after transplantation.
Highly efficient induced pluripotent stem cell reprogramming of cryopreserved lymphoblastoid cell lines
Authors: Kumar Satish , E. Curran Joanne , C. Espinosa Erika , C. Glahn David , Blangero John
Published: April 2020

Tissue culture based in-vitro experimental modeling of human inherited disorders provides insight into the cellular and molecular mechanisms involved and the underlying genetic component influencing the disease phenotype. The breakthrough development of induced pluripotent stem cell (iPSC) technology represents a quantum leap in experimental modeling of human diseases, providing investigators with a self-renewing and thus unlimited source of pluripotent cells for targeted differentiation into functionally relevant disease specific tissue/cell types. The existing rich bio-resource of Epstein-Barr virus (EBV) immortalized lymphoblastoid cell line (LCL) repositories generated from a wide array of patients in genetic and epidemiological studies worldwide, many of them with extensive genotypic, genomic and phenotypic data already existing, provides a great opportunity to reprogram iPSCs from any of these LCL donors in the context of their own genetic identity for disease modeling and disease gene identification. However, due to the low reprogramming efficiency and poor success rate of LCL to iPSC reprogramming, these LCL resources remain severely underused for this purpose. Here, we detailed step-by-step instructions to perform our highly efficient LCL-to-iPSC reprogramming protocol using EBNA1/OriP episomal plasmids encoding pluripotency transcription factors (i.e., OCT3/4, SOX2, KLF4, L-MYC, and LIN28), mouse p53DD (p53 carboxy-terminal dominant-negative fragment) and commercially available reprogramming media. We achieved a consistently high reprogramming efficiency and 100% success rate (> 200 reprogrammed iPSC lines) using this protocol.
A system for the high-throughput analysis of acute thermal avoidance and adaptation in C. elegans
Authors: Lia Andrei-Stefan , A. Glauser Dominique
Published: April 2020

Nociception and its plasticity are essential biological processes controlling adaptive behavioral responses in animals. These processes are also linked to different pain conditions in human and have received considerable attention, notably via studies in rodent models and the use of heat-evoked withdrawal behavior assays as a readout of unpleasant experience. More recently, invertebrates have also emerged as useful complementary models, with their own set of advantages, including their amenability to genetic manipulations, the accessibility and relative simplicity of their nervous system and ethical concerns linked to animal suffering. Like humans, the nematode Caenorhabditis elegans (C. elegans) can detect noxious heat and produce avoidance responses such as reversals. Here, we present a methodology suitable for the high-throughput analysis of C. elegans heat-evoked reversals and the adaptation to repeated stimuli. We introduce two platforms: the INFERNO (for infrared-evoked reversal analysis platform), allowing the quantification of the thermal sensitivity in a petri dish containing a large population (> 100 animals), and the ThermINATOR (for thermal adaptation multiplexed induction platform), allowing the mass-adaptation of up to 18 worm populations at the same time. We show that wild type animals progressively desensitize in response to repeated noxious heat pulses. Furthermore, analyzing the phenotype of mutant animals, we show that the mechanisms underlying baseline sensitivity and adaptation, respectively, are supported by genetically separable molecular pathways. In conclusion, the presented method enables the high-throughput evaluation of thermal avoidance in C. elegans and will contribute to accelerate studies in the field with this invertebrate model.
City of refuge (Ciudad de refugio)
Authors: Rengifo Sandra , Tsanakas Kostas
Published: April 2020

Este artículo presenta la serie fotográfica ‘City of refuge’ (Ciudad de refugio), de Kostas Tsanakas. Los textos aparecen como un acompañamiento o susurro de lo que evocan cada una de las imágenes y su conjunto. La perspectiva del escrito se instala desde una escritura experimental sobre los recorridos, lo que sugieren las imágenes, el ver el mundo a través de los ojos de Tsanakas y un acto de nomadismo presente en los fotógrafos del andar.
Investigación-creación y conocimiento desde los estudios artísticos
Authors: Gómez Pedro Pablo
Published: April 2020

En este artículo se plantea una idea de lo que significa conocer en el campo emergente de los estudios artísticos. Para tal fin, se propone que la investigación-creación es una configuración relacional-diferencial que nos permite abordar desde las artes la compresión del funcionamiento de la matriz colonial del poder. A su vez, la investigación-creación nos sirve para mostrar que el conocimiento no está restringido a las ciencias o a las artes, abriendo un horizonte, para la creación-investigadora más allá del campo académico, en el espacio ampliado de las prácticas sensibles, muchas de ellas empeñadas en la posibilidad de la reproducción y creación no colonial de la vida.
Měření inkluzivity školy: aplikace dvou nástrojů
Authors: Marques Karin
Published: April 2020

Abstrakt: Dne 1. 9. 2016 vstoupila v účinnost novela školského zákona (zákon č. 82/2015 Sb.), která s sebou přinesla nové pojetí podpory žáků se speciálními vzdělávacími potřebami. Upustila od kategorizace dětí, žáků a studentů podle jejich diagnóz a místo toho zavedla systém podpůrných opatření. Podíl integrovaných žáků ve třídách hlavního vzdělávacího proudu stoupá (ČŠI, 2017; Klusáček, 2015), a tak je čím dál aktuálnější otázka, jak má vypadat dobře prováděné inkluzivní vzdělávání v praxi. Hledala jsem inkluzivní školy, které by mohly sloužit jako příklad dobré praxe, abych je podrobila detailnějšímu zkoumání. Položila jsem si otázku, jak lze identifikovat inkluzivní školu v ČR. Snažila jsem se najít a aplikovat nástroj, kterým lze hodnotit míru inkluze na úrovni školy v českém vzdělávacím systému. Tato studie popisuje poznatky z implementace Nástroje pro hodnocení školy v oblasti inkluze (Tannenbergerová, 2014) a Standardů ISSA pro hodnocení pedagogické práce provedené v letech 2014–2015 na vybraných českých školách. Na výsledcích konkrétních škol demonstruji metodologické problémy, které s měřením souvisejí.

Klíčová slova: inkluzivní vzdělávání, inkluzivní škola, index inkluze, Standardy ISSA, hodnocení inkluze.
Revize kurikulárních dokumentů pro střední odborné školství
Authors: Kofroňová Olga
Published: April 2020

Příspěvek popisuje připravované revize kurikulárních dokumentů středního odborného školství: uvádí problémy, které byly identifikovány ve vztahu k naplňování jejich základních funkcí, a hlavní charakteristiky návrhu pojetí jejich revizí. Příspěvek dále představuje celkový rámec kurikulárních dokumentů i návrhy na flexibilní uspořádání školních vzdělávacích programů s využitím vzdělávacích modulů.
Subjective Responsibility of Spanish University Teachers: A qualitative pilot study
Authors: Pečivová Veronika
Published: April 2020

Abstract: Teacher subjective responsibility is a prominent component of teachers’ professional identity. It has a great impact on teachers’ attitudes to various aspects and ethical questions relating to their profession and thus influences their performance.Aims: The pilot study presented in this paper aimed to reveal the position of teacher subjective responsibility within the self-perceived identity of teachers and to find its relations to individual ingredients of teachers’ professional identity. The participants in our pilot study were four Spanish university teachers preparing future primary school teachers for their careers.Methods: To gain a deeper insight into the teachers’ perception of their subjective responsibility we opted for a qualitative design and conducted semi-structured interviews. Having chosen a phenomenological approach, we concentrated on the participants’ understanding of their subjective responsibility and its effects. We focused on the teachers’ self-perception and inquired about the path that had led them to their profession and also about their teaching experience, searching for links connecting these to their subjective responsibility.Results: The research results demonstrate that our participants do feel responsible for a number of issues and they also reveal a particularly strong connection between teacher subjective responsibility and their commitment. The inquiry also indicated that commitment, closely interconnected with subjective responsibility, comes with a price, affecting the personal lives of the participants.Conclusions: Although our preliminary findings are limited because of the small number of participants and the strategy of a single interview, we believe that we have taken the first steps to understanding teacher subjective responsibility regarding its position within the broader context of teachers’ professional identity.Keywords: teacher responsibility, teachers’ professional identity, university teachers, commitment, teachers’ professional ethics
Vzdělávání waldorfských učitelů – historické aspekty a aktuální diskuse
Authors: Zdražil Tomáš , Pleštil Dušan
Published: April 2020

Následující příspěvek se věnuje problematice vzdělávání učitelů waldorfských škol. V první části je věnována pozornost historickému vývoji vzdělávání antroposofi cky smýšlejících učitelů a v druhé části se článek zabývá cíli a aspekty učitelské přípravy pro rozvoj žáka v duchu idejí svobodných waldorfských škol.
Antioxidant properties of BJRI vegetable mesta-1 (Hibiscus sabdariffa L.)
Authors: Mollah Md. Abul Fazal , Tareq Md. Zablul , Bashar Kazi Khayrul , Hoque A. B. M. Zahidul , Karim Md. Meftahul , Zahid-Al-Rafiq Md.
Published: April 2020

Roselle or Mesta (Hibiscus sabdariffa) is one of the plants whose plant parts are used to prepare juices. The Roselle calyx is considered as a good source of antioxidants. But the antioxidant properties of BJRI (Bangladesh Jute Research Institute) released Roselle vegetable variety, BJRI vegetable mesta-1, is not quantified yet. With the objective of making this vegetable more popular among the consumers, an experiment was conducted at the Jute Agriculture Experimental Station, Bangladesh Jute Research Institute, Jagir, Manikganj to find out the antioxidant properties of BJRI vegetable mesta-1. Total four antioxidant components eg., total phenol content, total flavonoid content, proanthocyanidin content, anthocyanin content and three antioxidant activities eg., DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging, (FRAP) ferric ion reducing antioxidant power, H2O2 (hydrogen peroxide), radical scavenging were measured from the calyx sample of BJRI vegetable mesta-1. Among the four antioxidant components, total flavonoid contents (959.53 mg 100 g–1) posses the highest position and anothocyanine contents (0.17 mg 100 g–1) were in the lowest position. FRAP activities were highest among the antioxidant activities of the calyx of our studied vegetable mesta. Our findings represented the quantity of antioxidant contents of the calyx of BJRI vegetable mesta-1 which justify its uses as natural antioxidants. Thus, Roselle calyx may act as an alternative source of antioxidant rich natural herbal tea.
Occurrence of thermophilic fungal communities and its growth rate on different media and temperatures from available natural substrates
Authors: Birajdar Ganesh Mallikarjun , Kumbhar Vivekanand Ramchandra , Kadam Kalyan K , Bhale Udhav Narba
Published: April 2020

Thermophilic fungi are the chief components of the microflora that develops in heaped masses of plant materials, piles of agricultural and forestry products and other accumulation of organic matter. In this investigation, survey was conducted and collected different compost samples from eight localities of Osmanabad district. Among these localities, Naldurg and Dhoki sites showed highest number of organic substrates, while least in Itkal. Physicochemial properties i.e. nitrogen, phosphorus, potassium, total organic matter, total carbon and moisture were analysed from available composts and among them nitrogen was highest in molasses. Isolation of fungi was made from substrates and among five substrates, vermicompost and Farm Yard Manure (FYM) were recorded for highest species richness and % incidence while less in molasses. Among isolated thermophilic fungi, Aspergillus niger, A. flavus, Rhizoctonia solani, A. fumigatus and Rhizopus sp. found abundant in all the substrates and temperature ranges. Fungal species A. niger, Mucor mucedo, A. flavus and Pythium sp. Highest growth on all three media viz. Potato dextrose agar (PDA), Czapek’s Dox Agar (CZA) and Martins Rose Bengal (MBR) were recorded. A. niger and Rhizopus sp. were found dominant in tested media and temperature. Generally, the fungi show very little growth at 65 °C. Every temperature gradient showed the growth incidence in all substrates but room temperature (RT) and 35 °C showed richness of fungal incidence. Even some species showed the growth on some substrates at higher temperate (65 °C) to some extent.
„Die soziale Welt kleiner Betriebe“
Authors: Hien Wolfgang
Published: April 2020

Der Beitrag nimmt die Wiederauflage der 1990 publizierten Studie „Die soziale Welt kleiner Betriebe“ von Hermann Kotthoff und Josef Reindl zum Anlass, den Stellenwert dieser Studie für die Entwicklung der deutschen Arbeitssoziologie seit den 1960er Jahren Revue passieren zu lassen. Vor dem Hintergrund des nach wie vor dominierenden großindustriellen und technikfixierten Blicks blieb dieses Buch bis heute ein Solitär. Angesichts der heute sichtbaren Aufgliederung und Zersplitterung großer Betriebe macht die Wiederauflage der Studie von Kotthoff/Reindl die Notwendigkeit deutlich, die aktuelle soziale Situation der kleinen und mittleren Betriebe erneut zum Forschungsgegenstand zu machen.
Circularly polarized reconfigurable microstrip loop antenna using parasitic patches and PIN diodes
Authors: Kawdungta Supakit , Phongcharoenpanich Chuwong
Published: April 2020

This research proposes a novel circularly polarized (CP) reconfigurable microstrip loop antenna for 2.4–2.5 GHz advanced wireless communication using two parasitic patches and two PIN diodes. The reconfigurable antenna can alternate between right hand circular polarization (RHCP) and left hand circular polarization (LHCP) at the main beam by manipulating the ON/OFF status of the PIN diodes. Simulations were carried out for the optimal antenna parameters, and an antenna prototype was fabricated and experiments were undertaken. The simulation and measured results are in good agreement. The antenna achieves an impedance bandwidth of 2.4–2.5 GHz and unidirectional radiation pattern with a maximum gain of 5 dBic and 3-dB axial ratio for both RHCP and LHCP. As a result, the proposed reconfigurable antenna could be utilized to improve wireless communication performance. In essence, the novelty of this research lies in the utilization of parasitic patches and shorted PIN diodes to transform linear to circular polarization; and the reconfigurability of polarization between RHCP and LHCP.
Tunable balanced to balanced filtering power divider with high common-mode suppression
Authors: Zeng Cao , Hu Xue Han , Wei Feng , Shi Xiao Wei
Published: April 2020

In this paper, a tunable balanced-to-balanced in-phase filtering power divider (FPD) is designed, which can realize a two-way equal power division with high selectivity and isolation. A differential-mode (DM) passband with a steep filtering performance is realized by applying microstrip stub-loaded resonators (SLRs). Meanwhile, six varactors are loaded to the SLRs to achieve the center frequency (CF) and bandwidth adjustment, respectively. U-type microstrip lines integrated with stepped impedance slotline resonators are utilized as the differential feedlines, which suppress the common-mode (CM) intrinsically, making the DM responses independent of the CM ones. A tuning center frequency from 3.2 to 3.75 GHz and a fractional bandwidth (12.1–17.6%) with more than 10 dB return loss and less than 2.3 dB insertion loss can be achieved by changing the voltage across the varactors. A good agreement between the simulated and measured results is observed. To the best of authors' knowledge, the proposed balanced-to-balanced tunable FPD is first ever reported.
Nonlinear Pull-in Instability of Rectangular Nanoplates Based on the Positive and Negative Second-Order Strain Gradient Theories with Various Edge Supports
Authors: Zabihi A. , Ansari R. , Hosseini K. , Samadani F. , Torabi J.
Published: April 2020

Based on the positive and negative second-order strain gradient theories along with Kirchhoff thin plate theory and von Kármán hypothesis, the pull-in instability of rectangular nanoplate is analytically investigated in the present article. For this purpose, governing models are extracted under intermolecular, electrostatic, hydrostatic, and thermal forces. The Galerkin method is formally exerted for converting the governing equation into an ordinary differential equation. Then, the homotopy analysis method is implemented as a well-designed technique to acquire the analytical approximations for analyzing the effects of disparate parameters on the nonlinear pull-in behavior. As an outcome, the impacts of nonlinear forces on nondimensional fundamental frequency, the voltage of pull-in, and softening and hardening effects are examined comparatively.
EFFECT OF POTATO FLOUR SUBSTITUTE TO WHEAT FLOUR ON THE PHYSICAL QUALITY PROPERTIES OF CUPCAKE
Authors: GERÇEKASLAN Kamil , BOZ Hüseyin
Published: April 2020

In this study, it was investigated that the effect of the replacing of wheat flour with potato flour at various proportions (0, 2.5, 5, 10, 20%) on the quality properties of the cupcake samples. The volume, specific volume, baking loss and volume index values of the cupcake samples decreased significantly (p<0.01) with the increased potato flour level, while the weight, symmetry index, moisture, and ash content values increased. The replacement of wheat flour with the potato flour had a significant (p<0.05) effect on the textural properties of cupcakes. In general, it was observed that potato flour usage had a positive effect on cohesiveness value while it had a negative effect on the springiness value of cupcakes. It was detected that the increase in the potato flour level caused an increase in hardness value especially on the last day of storage. As a result of this study, it was concluded that potato flour may replace with wheat flour up to %5 without any adverse effects on the physical quality properties of the cupcakes.
ORGANIC ENRICHMENT OF SEDIMENTS: A CASE STUDY AT MARICULTURE SITE, PEGAMETAN BAY BALI, INDONESIA
Authors: Nasukha Afifah , Septory Reagan , Wibawa Gigih Setia , Runte Karl-Heinz
Published: April 2020

Mariculture industry has been developed progressively in Indonesia, where its impact on the surrounding aquatic environment is inevitable. The particulate wastes produced such as excess food and feces will be discharged from a marine farm and dispersed into the surrounding areas. This process could lead to organic enrichment of the receiving seabed sediment and gradually degrade water quality and disturb local benthic community as well as the aquatic ecosystem of the area. This study focused on determining the level of organic enrichment of sediment underneath four currently-active farms in Pegametan Bay, North Bali, Indonesia. The results showed that high accumulation of organic matters was evident in all sampling farms indicated by a significantly high particulate organic matter (POM) between 75.20 ± 2.57 and 92.97 ± 0.59%, and low redox values between -217.41 ± 2.74 and -343.57 ± 1.48 mV. A visual-based assessment also determined that the sediment had a silt and muddy texture with deep grey to black colorization with noticeable strong H2S odor. In this case, further investigations and monitoring efforts are needed in the near future to ensure the best management programs for sustainable farming and ecosystem both fish farmers and environmental regulators such as local government.
PENERAPAN REMEDIASI PADA SISTEM BUDIDAYA UDANG DI TAMBAK TANAH SULFAT MASAM (Studi Kasus di Kabupaten Berau, Kalimantan Timur)
Authors: Prihadi Tri Heru , Pantjara Brata
Published: April 2020

Remediasi tanah sulfat masam untuk tambak dapat meningkatkan produktivitas tanah yang lebih baik untuk budidaya udang sistem monokultur dan polikultur. Penelitian dilakukan bertujuan untuk mengetahui pengaruh remediasi tanah pada budidaya udang windu di tambak tanah sulfat masam. Penelitian dilakukan pada tambak milik masyarakat di Pulau Tempurung, Desa Kasai Kecamatan Pulau Derawan Kabupaten Berau Provinsi Kalimantan Timur. Karakterisasi tanah untuk mengetahui rona awal tambak tanah sulfat masam dilakukan sebelum budidaya. Prosedur perbaikan tambak tanah sulfat masam diadopsi dari hasil penelitian Balai Riset Perikanan Budidaya Air Payau dan Penyuluhan Perikanan (BRPBAPPP). Remediasi tanah dilakukan dengan tahapan pengolahan tanah, pengeringan dasar tambak, perendaman, dan pembilasan; dan dilanjutkan dengan pengapuran dan pemupukan. Pengapuran tambak menggunakan dolomit dengan dosis 1,0 ton per ha. Hasil penelitian menunjukkan bahwa tambak yang diremediasi menghasilkan udang windu sebanyak 357,15 kg/ha dan tanpa remediasi sebesar 100 kg/ha. Tambak yang diremediasi pada sistem polikultur menghasilkan udang windu 100,9 kg/ha dan ikan bandeng 330 kg/ha. Penerapan teknologi remediasi dasar tanah pada budidaya udang windu sistem monokultur berdasarkan analisis ekonomi sederhana memberi keuntungan sebesar Rp26.828.500,00 /ha/siklus dan BC rasio 4,68. Polikultur udang windu dan bandeng menghasilkan keuntungan sebesar Rp8.800.000,00 /ha/siklus dan BC rasio 2,47.Remediation of acid sulfate soil pond can increase the productivity of the soil used for shrimp farming with monoculture and polyculture systems. This study was conducted to determine the post effects of soil remediation on tiger shrimp cultured in acid sulfate soil pond. The study was conducted in one of the farms owned by a fish farmer in Tempurung Island, Kasai Village, Derawan District, Berau Regency, East Kalimantan Province. The characteristics of the soil were determined to serve as the baseline information before cultivation. The pond remediation followed the procedures set by the Research Institute for Brackishwater Aquaculture and Fisheries Extension, Maros. The soil reclamation was carried out following the subsequent stages: soil plowing, pond bottom drying, inundation, and flushing; followed by liming and fertilization. Ponds liming used a dolomite dose of 1 ton/ha. The results showed that the remediated acid sulfate soil ponds could produce tiger shrimp up to 357.15 kg/ha while non-remediated ponds only produced up to of 100 kg/ha. The remediated brackish fish pond used for polyculture system could produce tiger shrimp up to 100.9 kg/ha and milkfish up to 330 kg/ha. The application of soil remediation on ponds of tiger shrimp monoculture systems yielded a profit of Rp 26,828,500.00/Ha/cycle and BC ratio of 4.68. For polyculture of tiger shrimp and milkfish, the profit was Rp 8,800,000.00/Ha/cycle and BC ratio of 2.47.