bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of normal seminal plasma replacement on cryopreservation of sperm in patients with non-liquefied semen
Authors: Shao Shuai , Jiang Mei , Raymond Cespuglio , Zhang Nianping
Published: June 2024

Objective: To explore the effects of normal seminal plasma replacement on cryopreservation of human non-liquefied spermatozoa.
Methods: Sixty Semen samples (30 samples of normal semen and 30 samples of non-liquefied semen) were collected from infertile male patients in the Reproductive Medicine Center of Jingmen People's Hospital. After centrifugation, spermatozoa were divided into 5 aliquots, of which 2 aliquots were added with non-liquefied and normal seminal plasma, respectively. Computer-assisted semen analysis system (CASA) measured sperm motility after various periods of incubation (0, 0.5, 1 and 2 h). The remaining 3 aliquots of sperm were employed as follows for cryopreservation: a seminal plasma-free group in which sperm was preserved by adding sperm cryoprotectants; a non-liquefied semen-derived seminal plasma group for which sperm was added with non-liquefied plasma; a normal seminal plasma group for which sperm was added with normal seminal plasma. After the freezing-thawing process, sperm parameters, DNA integrity and ability to resist oxidative stress damage were again examined for these 3 groups.
Results: Incubation of normal semen plasma, without liquefaction, can improve the sperm motility. After cryopreservation, sperm parameters were significantly lower versus those of the sample not cryopreserved. Normal semen plasma can reasonably protect the sperm of unliquefied semen and maintain the sperm parameters. It can also maintain the DNA integrity and prevent oxidative stress injury.
Conclusion: Normal seminal plasma can maintain the semen key parameters after cryopreservation of non-liquefied semen. Protective effects observed with this normal seminal liquid might be due to the antioxidants remaining within the seminal liquid.
Limited transmission of microbial species among coral reef fishes from the Great Barrier Reef, Australia
Authors: Costa Vincenzo A. , Bellwood David R. , Mifsud Jonathon C.O. , Geoghegan Jemma L. , Harvey Erin , Holmes Edward C.
Published: June 2024

Background
Reef fishes account for one-third of all extant marine fishes and exhibit enormous biodiversity within a highly interactive ecosystem. Despite this, relatively little is known about the diversity and evolution of microbial species (bacteria, viruses, and eukaryotes) associated with reef fish, even though this may provide valuable insights into the factors that shape microbial communities within vertebrate hosts as well as the extent and pattern of cross-species transmission.
Results
Through metatranscriptomic sequencing we characterised the viruses, bacteria, and single-celled eukaryotes from 126 reef fish species inhabiting Lizard Island and Orpheus Island on the Great Barrier Reef, Australia. We assessed whether microbial communities differed between islands that are separated by approximately 450 kilometres, and to what extent viruses were able to emerge in new hosts. Notably, despite strong ecological interactions in the reef environment, and the presence of the same families and subfamilies of viruses and bacteria on both islands, there was minimal evidence for the cross-species transmission of individual microorganisms among fish species. An exception was the high prevalence of the opportunistic bacterial pathogen Photobacterium damselae among apparently healthy cardinalfishes from both islands, indicating that these fish species are natural reservoirs within the reef system.
Conclusions
These data suggest that reef fishes have microbial-host associations that arose prior to the formation of the Great Barrier Reef, leading to strong host barriers to cross-species microbial transmission and hence infectious disease emergence, even within a highly interactive and species-rich environment.
Improving The Quality Of Rye-Wheat Bread Varieties With The Use Of Non-Traditional Plant Raw Materials
Authors: Baiysbayeva Meruyet , Moldakulova Zilikha , Iskakova Galiya , Batyrbayeva Nurgul , Irmatova Zhyldyz , Izembayeva Assel
Published: June 2024

The article considers the possibility of solving the problem of increasing the nutritional and biological value of rye-wheat bread by enriching them with products of processing of local non-traditional plant raw materials - flaxseed flour and dietary fiber from rice husks. The research was carried out in two stages: firstly, flax flour was added to the recipe of rye-wheat bread in the amount of 5;10;15;20% to the mass of wheat flour. Secondly, to these experimental samples were added dietary fibers (hereinafter referred to as DF), which are prepared from rice husk without removal of amorphous silicon dioxide in the amount of 0,3;0,5;0,7% to the total mass of rye-wheat flour. The regularities of the influence of linseed flour and DF on the rheological properties of dough are given. The obtained results allow characterizing flour mixtures from rye-wheat and flax flour with the addition of DF as "average in strength", giving bread with sudficient volume. According to the results of the research the authors proposed the optimal dosage of flax flour (15%), DF (0.5%) and modes of technological process, allowing to obtain bread with good consumer properties. Addition of DF up to 0.5% and linseed flour in the amount of up to 15% allows to increase the nutritional and biological value of finished products, improves the gas-holding capacity and crumb structure, increases the moisture-holding capacity of bread, which in turn prevents the process of staling and thus increases the shelf life of finished products.
Short-wave infrared reflection for proximal caries detection
Authors: Litzenburger Friederike , Kunzelmann Karl-Heinz , Walter Elias , Schwendicke Falk , Hickel Reinhard , Heck Katrin
Published: June 2024

Objectives
This in vitro study analyzed the diagnostic performance of short-wave infrared reflection at 1050, 1200, 1300 and 1550 nm for proximal caries detection.
Materials and Methods
250 extracted posterior teeth with sound or carious proximal surfaces were examined using reflection imaging at 1050–1550 nm. Digital bitewing radiography served as an alternative index test and micro-computed tomography as reference standard. Two examiners independently evaluated all images and the reference standard twice using method-specific classification systems.
Results
The overall accuracy of reflection imaging at 1550 nm and bitewing radiography were similar between 72.4 and 73.2%. Reflection at 1050–1300 nm revealed higher values than bitewing radiography (78.4–80.0%). Short-wave infrared reflection showed increasing sensitivity and decreasing specificity for proximal carious lesions with increasing wavelength. Radiography revealed lower values of sensitivity paired with higher values of specificity than short-wave infrared reflection. Reflection imaging at increasing wavelength revealed increasing false positive and decreasing false negative ratings. Intra- and inter-examiner reliability revealed almost perfect agreement for all assessments.
Conclusions
Short-wave infrared reflection holds high diagnostic potential for proximal caries detection. At 1050 nm, reflection imaging reveals higher diagnostic accuracy than bitewing radiography and less tendency to overestimate caries than at 1200–1300 nm. The application of wavelengths longer than 1050 nm improves sensitivity and reduces specificity of short-wave infrared reflection. Clinical Relevance: As an alternative to bitewing radiography, short-wave infrared reflection at 1050 nm demonstrated the highest diagnostic potential and proved to be a clinically relevant non-ionizing option for the detection of proximal caries.
Research on the Fusion of FY4A Satellite Data and Station Observation Data for Heavy Fog Recognition
Authors: Zhenhai Yao , Chuanhui Wang , Chun Jiang
Published: June 2024

Satellite observations of fog possess the technical advantages of wide coverage and high spatio-temporal resolution. However, the accuracy of fog identification is subject to errors due to various factors such as atmospheric conditions and lighting. This study aims to enhance the accuracy of fog identification by integrating ground station observations with satellite data. Taking Anhui Province as a case study, we combined multi-spectral data from the FY-4A satellite with ground-based visibility observations. Using threshold method (THD), support vector machine (SVM), random forest (RF), and gradient boosting machine (XGB) as multi-source algorithms, we established a fog region identification model. The nearby pixel method was employed to validate the fog region identification results, leading to the selection of the optimal algorithm. The results indicate that machine learning algorithms outperform the traditional threshold method (THD) in fog region identification. Among the SVM, RF, and XGB algorithms, RF exhibited the highest median accuracy (0.66) and excellent robustness, making it the optimal choice. Case studies demonstrate that the identification results based on the random forest algorithm effectively reflect the spatial distribution of the fog region. Although the differences between the pre-and post-correction identification results are not significant in the image, the accuracy is highly influenced by factors such as lighting, cloud cover, and fog intensity, leading to instability. After correction with ground station data, the accuracy improved significantly (up to 67.2%) and became more stable. Compared to single-data fog monitoring methods, the integration of FY4A satellite data and ground station observations offers multi-dimensional observational complementarity, enabling technological advancements that enhance the digitization and spatialization of fog observations.
Upregulation of serum miR 155 and miR 30c as a Potential Biomarker for Alzheimer’s Disease
Authors: Kafshdooz Taiebeh , Farajnia Safar , Sharifi Rasoul , Najmi Safa , Pourseif Mohammad Mostafa
Published: June 2024

Alzheimer's disease (AD), the most common type of dementia, is a serious neurodegenerative disorder for which there is currently no cure. However, available medications can help alleviate the symptoms of the disease. Therefore, it is essential to promptly and accurately diagnose the condition and understand the molecular mechanisms involved in its progression. Disruption of microRNAs (miRNAs) is implicated in the development of neurodegenerative conditions, such as Alzheimer's disease (AD). The research was carried out in order to determine the significance of Mir 30c, and Mir 155 in serving as a diagnostic biomarker The microarray data set GSE138260 was obtained from the Gene Expression Omnibus (GEO) database hosted by the National Center for Biotechnology Information (NCBI) In order to determine gene ontologies, pathways, and networks, one must conduct a comprehensive analysis Blood samples were collected from 30 individuals with AD and 30 individuals without the condition. RNA was extracted from the serum samples, converted to cDNA, and then the real-time PCR method was used to measure the expression level of Mir 30c and Mir 155 . The study's findings indicated that the copy number levels of copy number levels of Mir 30c and Mir 155 were increased. Bioinformatics analysis revealed that these microRNA target pathways are associated with Alzheimer's disease. The cut-off value for this Mir´s demonstrates the trade-off between sensitivity and specificity in diagnostic testing.
Tension load affects MYOZ2 expression and mediates paraspinal myofiber transformation in adolescent idiopathic scoliosis
Authors: Gao Yuan , Ying Jia , Lai Bowen , Jiang Heng , Zhou Xuhui
Published: June 2024

Objective To investigate the difference of typeⅠand typeⅡmyofibers of paraspinal muscles between the concave and convex side of main thoracic curve in adolescent idiopathic scoliosis (AIS) and its regulatory mechanism.
Methods The paraspinal muscle samples of 46 patients with AIS were collected and stained with ATPase. The myofiber parameters were measured and compared between the concave and convex side and among different vertebrae. The correlation between myofiber parameters and clinical data of the patients was analyzed. The paraspinal muscle samples of 5 AIS patients were selected for transcriptome RNA sequencing and RT-qPCR plus Western-blot were used to verify the results. Meanwhile, the correlation between the mRNA expression and myofiber parameters were analyzed. Finally, The expression of microRNAs between the concave and convex side were screened by microRNA sequencing and verified by RT-qPCR. In addition, the correlations between the microRNAs expression and myofiber parameters were analyzed to explore the possibility of microRNA regulating myofiber transformation.
Results There was transformation between typeⅠ and typeⅡ myofibers especially in the apical vertebrae region. Although the transformation may be a secondary change under the different tension load, it is closely related to the progress of curvature in AIS. The expression of MYOZ2 on the convex side was significantly different from that on the concave side, and the MYOZ2 expression was closely related to myofiber parameters.There was a significant difference in the expression of miR-499-5p and miR-133a-3p between the concave and convex side, and the differences of miR-499-5p and miR-133a-3p expression were closely related to to myofiber parameters.
Conclusion In AIS patients, the tension load was higher on the convex side and lower on the concave side, which caused an increased expression of miR-499-5p and miR-133a-3p in the paraspinal muscles on the convex side and a decrease expression on the concave side, which inhibited the expression of MYOZ2 on the convex side and promoted the expression of MYOZ on the concave side, and ultimately resulted in the transformation of type II myofibers to type I on the convex side and the transformation of type I to type II on the concave side.
Tryptophan depletion impairs CD8+ T-lymphocyte proliferation by preventing the activation-induced metabolic shift towards glycolysis
Authors: Zhu Jingjing , Bombart Raphaële , Corbet Cyril , Gerin Isabelle , Bommer Guido , Gomard Tiphanie , Klaessens Simon , Boudhan Loubna , Eynde Benoit Van Den
Published: June 2024

Non-response in cancer immunotherapy poses a significant challenge, often attributed to poorly understood immune resistance mechanisms. Indoleamine 2,3-dioxygenase (IDO1), frequently expressed in advanced-stage cancers, contributes to this resistance by fostering an immunosuppressive environment through tryptophan degradation along the kynurenine pathway. While the association between IDO1 and CD8 T lymphocyte dysfunction is widely accepted, the precise mechanisms underlying T lymphocyte dysfunction via tryptophan catabolism remain debated. To elucidate these mechanisms, we used genome-wide CRISPR/Cas9 knockout screening in murine CD8+ T lymphocytes, searching for genes whose inactivation favored proliferation in low-tryptophan conditions. Strikingly, a majority of identified genes coded for proteins involved in mitochondrial function. By further exploring the impact of tryptophan deprivation on metabolism, we observed that CD8+ T cells, when activated under tryptophan shortage, fail to shift their metabolism towards glycolysis and instead rely on oxidative phosphorylation (OXPHOS) for energy production. Inactivating OXPHOS restored proliferation by forcing glycolysis despite tryptophan shortage. Since the activation-induced metabolic shift is essential to provide the macromolecules required for proliferation, our results provide a mechanistic rationale to explain the IDO1-induced proliferation arrest of CD8+ T lymphocytes.
The Alleviating Effect of Gallic Acid on Chemotherapy-Induced Myelosuppression
Authors: Luo Junyi , Zhang Zhaoxia , Jin Liming , Wang Zhaoying , Sun Qiuyue , He Dawei
Published: June 2024

Background
This study aims to investigate the alleviating effects of Gallic Acid (GA) on chemotherapy-induced bone marrow suppression.
Methods
A mouse model of bone marrow suppression was established in BALB/c mice using intraperitoneal injections of cyclophosphamide (CTX). Mice were treated with low (100 mg/kg/d), medium (200 mg/kg/d), and high (400 mg/kg/d) doses of GA to mitigate the CTX-induced bone marrow suppression. The efficacy of GA in alleviating chemotherapy-induced bone marrow suppression was evaluated through blood cell counts, immune organ (thymus and spleen) indices, bone marrow nucleated cell (BMNC) counts, cell cycle, apoptosis, histopathology of bone marrow and spleen, and analysis of splenic hematopoietic factors.
Results
CTX induced a decrease in peripheral blood and BMNC counts, reduced spleen and thymus indices, and abnormal pathology of bone marrow and spleen, as well as disturbances in hematopoietic factors. GA was able to alleviate these abnormalities in the bone marrow. It modulated cell proliferation and apoptosis, adjusted the proportion of cells in the G0/G1 phase, and reduced apoptosis in femoral bone marrow.
Conclusion
GA can alleviate the atrophy of immune organs, relieve the proliferation blockade of bone marrow cells, inhibit bone marrow cell apoptosis, and promote the recovery of the spleen and hematopoietic factors, thereby mitigating CTX-induced bone marrow suppression. The study confirms the potential of the natural compound GA as an effective adjunct in alleviating CTX-induced bone marrow suppression, offering significant clinical application potential. These findings provide a theoretical basis and experimental evidence for developing new adjunct chemotherapy treatment strategies.
Examining Pessary Use and Satisfaction in Managing Pelvic Organ Prolapse: Results From a Cross-Sectional Multicentre Patient Survey
Authors: Mussawar Minhal , Khademioore Sahar , Chandra Astha , Hanafimosalman Mehrshad , Chan Garson
Published: June 2024

Background
Vaginal pessaries are a common method of managing pelvic organ prolapse (POP), as well as different types of urinary incontinence, allowing patients to successfully improve overall quality of life. Yet despite their positive attributes, there are several reasons why patients may choose to discontinue using pessaries and proceed with surgery to treat their condition instead. This study aimed to examine the factors associated with successful and unsuccessful pessary fittings, explore ideal characteristics of a pessary from a patient's perspective, and explore patients' experiences of pessary use in treating POP.
Methods
Participants completed an online survey regarding pessary use and ideal characteristics of a pessary. Participants were recruited from social media advertisements, online support groups for women’s health-related conditions, and pelvic floor clinics.
Results
A total of 100 participants were recruited, of which 77 fully completed the survey. Respondents cited pelvic pain, excess vaginal discharge and odor, as well as difficulty with pessary placement as the most common issues related to pessary use. Easy insertion, removal, and relief from side effects were the most commonly reported ideal characteristics for pessary use.
Conclusion
Patients had important concerns with pessary use and a high number either stopped or were considering stopping even when it improved their POP. Whilst pessaries can help in the management of POP, further improvement is warranted to increase pessary use, such as through the development of user-friendly designs, or applicators to aid with fitting.
Is Laparoscopic Hernia Repair Safe for Boys as Well as Girls? Results of Percutaneous Internal Inguinal Ring Suturing with a Filler Cannula
Authors: Kandırıcı Aliye , Dokucu Ali İhsan
Published: June 2024

Purpose
The aim of our study demonstrate the safe applicability of this method in all patients regardless of gender by minimizing hematoma and spermatic cord injuries that may occur by using a filling cannula needle used to avoid vascular injuries in medical aesthetic applications.
Methods:
The files of 102 patients who underwent laparoscopic inguinal hernia repair with the diagnosis of inguinal hernia between the ages of 0–18 between January 2018 and January 2023 were evaluated retrospectively for the presence of demographic and postoperative recurrence. A total of 102 patients underwent 126 PIRS (Percutaneous Internal Ring Suturing) procedures.
Results
Patients were divided into needle group (60.8% n: 62) and cannula group (39.2% n: 40). Of the 102 cases, 64.7% were female (n: 66) and 35.3% were male (n: 36). Recurrence rates did not statistically significant difference compared to the groups (p > 0.05).
Conclusions
In our study, we showed that PIRS technique with the cannula needle can be applied safely and with high success rates in boys as well as girls because it is almost no harmful to the surrounding tissues and facilitates peritoneal dissection.
Low-cost Millimeter Scale Single-Layer MoS2 Synthesis via Chemical Vapor Deposition
Authors: Küçük Bengisu Alkım , Çağlar Mehtap Aygün , Turgut Güven
Published: June 2024

Two-dimensional (2D) materials are more attractive after the discovery of graphene. Among them, molybdenum disulfide (MoS2) has been one of the most studied materials due to its striking properties. The monolayer MoS2 has been mostly deposited by the chemical vapor deposition (CVD) method, and its properties have been tuned by the CVD parameters. However, there is still a need to deposit large-area MoS2 monolayers more cheaply. In this study, we carried out a controlled synthesis of MoS2 monolayers with large lateral sizes via the CVD method. The lateral size, number of layers, the distribution of MoS2 flakes have been tuned with the CVD parameters, which are catalyst amount, growth time, temperature, gas flow rate, sulfur location, and boat type. The synthesized MoS2 monolayers were analyzed by optical microscope, micro-Raman and photoluminescence (PL) spectroscopy, scanning electron microscope (SEM), and atomic force microscope (AFM). A strong dependency between the lateral sizes and layer numbers of MoS2 monolayers and CVD deposition parameters has been found. The continuous monolayer film of MoS2 has been synthesized by using a side-opened quartz. The results show a low-cost way for controllable synthesis of MoS2 monolayers. The monolayer films can be good candidates for device applications.
Unpaired image-to-image translation with diffusion adversarial network
Authors: Tu Hangyao , Wang Zheng , Zhao Yanwei
Published: June 2024

Unpaired image translation with feature-level constraints presents significant challenges, including unstable network training and low diversity in generated tasks. This limitation is typically attributed to the following situations: 1. The generated images are overly simplistic, which fails to stimulate the network's capacity for generating diverse and imaginative outputs. 2. The images produced are distorted, a direct consequence of unstable training conditions. To address this limitation, the Unpaired image-to-image translation with diffusion adversarial network (UNDAN) is proposed. Specifically, our model consist two module:(1)Feature fusion module: In this module, one-dimensional SVD features are transformed into two-dimensional SVD features which using the Convolutional two-dimensionalization method, enhancing the diversity of images generated by the network. (2) Network convergence module: In this module, the generator transitions from the U-net model to a superior diffusion model. This shift leverages the stability of the diffusion model to mitigate the mode collapse issues commonly associated with adversarial network training. In summary, the CycleGAN framework is utilized to achieve Unpaired image translation through the application of cycle-consistent loss.Finally, the proposed network was verified from both qualitative and quantitative aspects. Experiments show that the method proposed can generate more realistic converted images.
1-(1-naphthylmethyl)-piperazine inhibition assay successfully rules out efflux pump overexpression in Acinetobacter baumannii
Authors: Zosim Victor , Mullié Catherine , Peltier François , Potron Anaïs , Choquet Morgane
Published: June 2024

Background. Antimicrobial resistance (AMR) in ESKAPE pathogens, notably in carbapenem-resistant Acinetobacter baumannii, is a pressing global health concern, contributing to significant AMR-associated mortality. Efflux pump overexpression plays a crucial role in the multidrug resistance (MDR) of A. baumannii, but the identification of efflux-overexpressing strains remains challenging.
Methods. We evaluated the performance of an efflux pump inhibition assay in comparison with RT-qPCR, to assess efflux pump overexpression in a collection of clinical A. baumannii strains. Sixty MDR strains and a wild one were analyzed.
Results. The inhibition assay was positive for 34 and negative for 27 strains, respectively. Results were in agreement with RT-qPCR in 67.2% of the tested strains (39/58). Cohen's kappa showed a fair agreement between inhibition assay and RT-qPCR (Cohen’s kappa = 0.37). Inhibition by NMP, but not PAβN, was in moderate agreement with RT-qPCR (Cohen’s kappa = 0.41).Furthermore, gpi alleles were associated with efflux pump overexpression (p = 0.03), suggesting potential links between genetic diversity and efflux pump overexpression. RT-qPCR showed a significant efflux pump overexpression for 4 (16.7%) out of 24 inhibition assay negative strains.
Conclusions. Our findings support the ability to reliably rule out efflux pump overexpression in A. baumannii strains displaying a negative result with an inhibition test relying on NMP. However, confirmatory analyses are necessary for strains that test positive.
An Energy-efficient Task Offloading Model based on Trust Mechanism and Multi-agent Reinforcement Learning
Authors: Fengjun Shang , Guo Jia
Published: June 2024

A task offloading model based on deep reinforcement learning and user experience degree is proposed. Firstly, after users generate blockchain tasks, Proof of Work (PoW) consensus mechanism is introduced to pack the transaction information into blocks to ensure the real reliability of the interaction information in the system. Then, the user experience degree is defined by introducing the total system consumption delay and user gain, and the goal of optimal user experience degree is constructed. Furthermore, the deep reinforcement learning algorithm is used to optimize the offloading model, and the deep reinforcement learning model is constructed by taking the size of the transaction data and the difficulty of the PoW consensus process as the network state, the task offloading and resource allocation relationship between the user and the edge server as the network action, and the user experience as the network reward. Finally, the gradient descent method and back propagation algorithm are used to train the depth network until convergence, and the optimal offloading and resource allocation decision is obtained, and the superiority of the offloading model and algorithm proposed in this thesis is verified by simulation.
Relationship between environmental pollution and mitochondrial DNA copy number in European and East Asian populations: a Mendelian randomization study
Authors: Zhang Binbin , Dou Bin , Lu Chuan , Yan Qi , Zhaxi Dawa , Wei Shuqing , Luo Xiang , Gu Wenzuo , Li Kewen
Published: June 2024

BACKGROUND
In recent years, the incidence of diseases associated with environmental pollution has increased dramatically worldwide. Previous studies have shown that mitochondrial DNA (mtDNA) copy number is a potential biomarker for diseases caused by environmental pollution, and therefore, the causal relationship between environmental pollution and mtDNA copy number needs to be further explored.
METHODS
We performed Mendelian randomization analyses of European and Asian populations using a large amount of publicly available genome-wide association study (GWAS) pooled data. Genetic loci that are independent of each other and strongly associated with environmental pollution were selected as instrumental variables, and the inverse variance weighting (IVW) method was used as the primary analytical method. Cochrane's Q-test was used to assess heterogeneity. Multiplicity was checked using MR-Egger regression test.MR-PRESSO method was used to identify outliers. Sensitivity analysis was performed using leave-one-out. The results were assessed based on effect indicator dominance ratio (OR) and 95% confidence interval (CI).
RESULTS
In the European population, genetically predicted PM2.5 (p = 0.341), PM2.5-10 (p = 0.954), PM10 (p = 0.710), nitrogen dioxide (p = 0.196), nitrogen oxides (p = 0.524), workplace full of chemical or other fumes (p = 0.194), workplace with a lot of cigarette smoke from other people smoking (p = 0.847), workplace had a lot of diesel exhaust (p = 0.677), workplace very cold (p = 0.541), workplace very cold (p = 0.778), workplace very hot (p = 0.554), and workplace very noisy (p = 0.973) were not associated with risk of mtDNA copy number. In the Asian population, genetically predicted PM2.5 (p = 0.990), PM2.5-10 (p = 0.739), PM10 (p = 0.537), nitrogen dioxide (p = 0.341), and nitrogen oxides (p = 0.735) were not associated with the risk of mtDNA copy number. Sensitivity analysis proved the stability of the results.
CONCLUSION
The results of this Mendelian randomization do not support a causal relationship between environmental pollution and mtDNA copy number. However, the causal relationship found in this study still needs to be further explored.
Analysis and suppression of the negative effect of electromagnetic characteristics of wheel hub motor drive system on vehicle dynamics performance
Authors: Deng Zhaoxue , Luo Xiaoliang , Liao Xiangning , Li Xingquan , Du Zixue , Hou Mengmeng , Wei Hanbing
Published: June 2024

This paper analyses the negative impact of electromagnetic characteristics caused by air gap eccentricity in hub motor drive systems on vehicle dynamics. To further improve the vehicle dynamics performance. Firstly, the electromagnetic coupling equations and radial force (RF) equations are combined to calculate the changes in the electromagnetic characteristics of each winding phase under different eccentricities, and the RF measurement rig is designed and constructed to verify the accuracy of the numerical analysis calculation results. Secondly, the principle of longitudinal-vertical unbalanced radial force (URF) calculation is proposed, and the coupled dynamics model of the vehicle considering the URF is established to analyse the dynamic response characteristics of the vehicle under various working conditions. Finally, the structural parameters of the motor are optimized, and the optimal structural dimensions of the motor are obtained using the NSGA-II genetic algorithm, and the longitudinal-vertical URF is reduced by 11.68% and 6.81%, respectively, which effectively suppresses the negative influence of the electromagnetic characteristics of the wheel-hub motor drive system.
Systematic Review: Communication Model in Stroke Patients With Verbal Communication Disorders
Authors: Setianingsih Evi , Upoyo Arif Setyo
Published: June 2024

Aphasia is a manifestation of the impact of stroke disease that affects communication abilities and occurs due to damage to the brain area that regulates the language center, precisely in the Broca and Wernicke areas. Verbal communication disorders affect the life and quality of life of post-stroke patients, hence various rehabilitative therapies have been developed, one of which is using Constraint Induced Aphasia Therapy. This study aims to systematically review the influence of Constraint Induced Aphasia Therapy on the communication abilities of aphasia patients due to stroke. The systematic review design uses electronic data sources such as PubMed, Sciencedirect, and ASHA Publications. Selected journals used keywords such as "Constraint Induced Aphasia Therapy" and "aphasia and stroke" with the following inclusion criteria: articles published from 2013–2023, with full texts in English, consisting of randomized controlled trials (RCT), patients with aphasia (verbal communication disorders), and interventions of Constraint Induced Aphasia Therapy capable of restoring verbal communication disorders. The provision of communication card therapy intervention affects the verbal communication abilities of aphasia patients due to stroke. The clear changes are seen in the understanding of the messages conveyed and the pronunciation of what wants to be expressed. The duration and follow-up period of care affect the long-term impact of the expected effects. Constraint Induced Aphasia Therapy is effective in improving verbal communication abilities. Through standardized communication assessment instruments for aphasia, it shows optimal results in improving verbal communication.
GESTIÓN ADMINISTRATIVA Y SU INCIDENCIA EN EL DEPARTAMENTO DE RRHH DEL GAD DEL CANTÓN NOBOL
Authors: Zambrano Zambrano Stefany Xaviera , Quiñonez Cercado Mónica del Pilar
Published: June 2024

El propósito de este estudio fue analizar la gestión administrativa en el cumplimiento de los objetivos del departamento de Talento Humano del Gobierno Autónomo Descentralizado del cantón Nobol, ya que se define a la gestión administrativa como un conjunto constante de acciones destinadas a optimizar el uso de recursos, para que las decisiones correctas beneficien a las organizaciones y al talento humano. De este modo, la investigación adoptó un enfoque mixto, combinando el análisis de datos cuantitativos y cualitativos, así mismo, se empleó un enfoque descriptivo para detallar las características y la realidad del objeto de estudio, mediante métodos estadísticos y el análisis de datos recopilados de la encuesta realizada a 98 empleados de la institución. Entre los resultados, se evidenció una calificación “regular” del 76% a la gestión administrativa del talento humano, no obstante, existe un 90% de aprobación en cuanto a que hay una gestión administrativa apropiada para cumplir objetivos de talento humano.
GESTIÓN ADMINISTRATIVA EN EL CUMPLIMIENTO DE PROGRAMAS Y PROYECTOS EN EL GAD PARROQUIAL RURAL PUERTO CAYO
Authors: Quiñónez Cercado Mónica del Pilar , Coya Bravo Anabella Jamileth
Published: June 2024

En el contexto del Gobierno Autónomo Descentralizado Parroquial Rural de Puerto Cayo de la provincia de Manabí, la gestión administrativa en el cumplimiento de programas y proyectos es esencial para el desarrollo local. Sin embargo, se enfrenta a desafíos como la asignación de recursos y la planificación estratégica. Este estudio buscó determinar cómo incide la gestión administrativa en el cumplimiento de programas y proyectos durante el período 2022. La metodología empleada consistió en el método deductivo e inductivo, además de la entrevista aplicada al presidente y las encuestas dirigidas a los demás funcionarios público. Entre los resultados el 75% de los encuestados considera que la gestión administrativa ha facilitado en gran medida el cumplimiento de los programas y proyectos, mientras que el 87.5% indica que los recursos se utilizan de manera óptima. Aunque el 62.5% percibe que la asignación de presupuesto es efectiva en su mayoría, aún hay áreas de mejora en la planificación estratégica y la supervisión de la ejecución de proyectos.
GESTIÓN DE TALENTO HUMANO Y EL DESEMPEÑO LABORAL DEL GAD MUNICIPAL DE PORTOVIEJO
Authors: Moreira Loor Jonathan Esequiel , Rodríguez Bravo Argenis Gabriel
Published: June 2024

Este estudio se enfocó en analizar la gestión de talento humano y su incidencia en el desempeño laboral en el Gobierno Autónomo Descentralizado Municipal del cantón Portoviejo. La metodología incluyó la aplicación de técnicas de recopilación de datos, como la entrevista y encuestas, a empleados de la Dirección de Talento Humano. Los resultados revelaron que un 80% de los empleados perciben que las prácticas de gestión del talento humano influyen positivamente en su desempeño laboral. Asimismo, el 75% de los encuestados que reciben apoyo adecuado por parte de la dirección de talento humano muestran niveles más altos de compromiso y satisfacción laboral. En cuanto a la concordancia entre programas de capacitación y funciones laborales, el 57% de los empleados indicaron que los programas de capacitación siempre van en línea con sus responsabilidades laborales.
INFLUENCIA NORMATIVA 401 CONTROL INTERNO EN EL ÁREA ADMINISTRATIVA DEL DISTRITO DE SALUD 13D03
Authors: Calle García Aldrin Jefferson , Indio Curimilma Karen Jamilet
Published: June 2024

Esta investigación se centró en la influencia de la Norma de Control Interno 401 en el área administrativa del Distrito de Salud 13D03 Jipijapa – Puerto López, provincia de Manabí. La problemática identificada radica en la implementación inconsistente de los procesos establecidos por la normativa, específicamente en la separación de funciones, la rotación de labores, y la autorización y supervisión de transacciones. El objetivo del estudio fue determinar de qué manera influye la Norma de Control 401 en el área administrativa. La metodología incluyó un enfoque cuantitativo con el uso de encuestas aplicadas a 11 funcionarios del área administrativa, utilizando métodos inductivo, deductivo y analítico. Los resultados revelaron que el 36.36% considera la separación de funciones de manera regular, mientras que solo el 27.27% ve la rotación de labores como frecuente o muy frecuente. En cuanto a la autorización de transacciones, el 36.36% la considera efectiva y el 27.27% muy efectiva. La supervisión es vista como efectiva por el 36.36% y muy efectiva por el 18.18%. Las auditorías internas y revisiones se realizan regularmente según el 27.27%, aunque un 27.27% indica que son ocasionales.
El Programa Nacional de Educación Solidaria durante la gestión ministerial de Daniel Filmus (Argentina, 2003-2007)
Authors: Amar Hernán Mariano
Published: June 2024

En este artículo, se analiza la política diseñada por el Programa Nacional de Educación Solidaria, bajo la presidencia de Néstor Kirchner. No sólo se examina su misión política y educativa, sino también la relación que promovió entre el Estado y la sociedad civil para el logro de sus objetivos, durante la gestión ministerial de Daniel Filmus. Para ello, se adoptó como estrategia metodológica el enfoque cualitativo y el análisis interpretativo de las publicaciones sobre aprendizaje-servicio, que fueron elaboradas por el Ministerio de Educación, Ciencia y Tecnología de la Nación entre 2003 y 2007. Esos materiales se indagaron desde el prisma y las categorías de una ciencia social histórica: esto es, como un conjunto de textos que condensaron la visión del Estado Nacional, en una coyuntura particular, sobre la problemática de la Educación Solidaria en el campo educativo argentino. Por último, entre otros hallazgos se sostiene que este programa nacional se propuso impulsar el trabajo articulado entre el Estado y la sociedad civil para contribuir con la Educación Solidaria a los objetivos de las llamadas políticas de “inclusión” con “calidad educativa”, que se fueron configurando durante el ministerio de Filmus con el fin de abordar los problemas educativos y sociales generados o agravados por las reformas neoliberales de los años noventa.
Impacts of different El Niño events in the decaying summer on the oceanic source of summer rainfall for eastern China: A perspective from stable isotope
Authors: Peng Peiyi , Zhang Yiming , Chen Jie , Zhang Xunchang John , Li Xiuzhen , Xu Di
Published: June 2024

Extreme precipitation in eastern China (EC) is closely related to the diversity of the decaying phases of El Niño (warm-pool El Niño, i.e., WP El Niño and cold-tongue El Niño, i.e., CT El Niño), but little attention is paid to how the El Niño event variability influences precipitation sources for EC from an isotopic perspective. Stable isotopes are ideal physical tracers that can distinguish different sources of precipitation and quantify their relative contributions to precipitation. Accordingly, this study investigates spatiotemporal variations of water vapor flux and oceanic fraction to precipitation during different ENSO events by an isotopic mixing model. The results show that spatiotemporal patterns of moisture divergence for the decaying phase of WP El Niño are different from that of CT El Niño. The oceanic fraction anomalies present similar spatiotemporal trends with advection fraction anomalies. The spatiotemporal variations of precipitation source anomalies for different El Niño events are closely related to atmospheric circulations, i.e., the intensity and location of the western Pacific subtropical high (WPSH). These findings provide isotopic insights into the precipitation sources by El Niño events in EC. Future studies may further focus on the mechanisms producing extreme precipitation between the two kinds of El Niño.
Análisis de la realidad económica empresarial en Pasto frente a la pandemia del COVID-19
Authors: Bennett Muñoz John Ernesto , Argoti Chamorro Ana Cristina , Revelo Ramírez Luis Giovanni
Published: June 2024

El artículo tiene como propósito presentar y analizar algunos resultados obtenidos en la investigación profesoral «Situación económica empresarial por pandemia COVID-19», cuyo objetivo general fue analizar la coyuntura económica del sector empresarial de Pasto ante la crisis desencadenada por la pandemia COVID-19. Su enfoque primordial fue identificar las respuestas empresariales a esta situación y proponer estrategias de gestión. El estudio se inició con un perfil detallado de las empresas, abordando aspectos como su actividad, origen de financiamiento, tamaño y estructura jurídica. La metodología adoptada fue de carácter cuantitativo, descriptivo y transversal, empleando la encuesta como principal instrumento de recolección de datos. Esta encuesta se dirigió a directivos de empresas de Pasto, lo que permitió realizar un análisis de la situación general de las pequeñas y medianas empresas de la ciudad. Los resultados obtenidos permitieron una evaluación de la dinámica empresarial en la región, revelando las estrategias empleadas por las empresas pastusas para mitigar los impactos económicos derivados de la pandemia. Con base en estos resultados, se propusieron estrategias de gestión empresarial orientadas a asegurar la viabilidad y adaptabilidad de las organizaciones en el contexto actual. Es crucial resaltar que la implementación de prácticas efectivas de gestión empresarial desempeña un papel fundamental en la preservación y el progreso de las empresas frente a desafíos como la pandemia de COVID-19. El estudio proporciona una visión detallada de la situación económica de las empresas en Pasto durante la pandemia, así como de las estrategias adoptadas para enfrentarla. Las recomendaciones de gestión empresarial derivadas de este análisis están diseñadas para fortalecer la resiliencia y la capacidad de adaptación de las organizaciones ante los desafíos económicos presentes y futuros.
Respiratory Complications in the Inborn Errors of Metabolism
Authors: Currò Arianna , Pirrone Martina , Giunta Ivana , Maviglia Antonia , Di Rosa Gabriella , Spoto Giulia
Published: June 2024

:

Inborn Errors of Metabolism (IEMs) are a large heterogeneous group of monogenic disorders
that affect specific metabolic pathways. Although the clinical picture is variable and shows
a multisystemic impairment, most of these defects encompass neurologic symptoms and signs.
The respiratory involvement may represent a late-onset feature of a complex multisystemic disease
or the only manifestation of an underlying IEM. The severity of the respiratory disease can
range from mild aspecific symptoms, such as tachypnea and respiratory distress in response to
metabolic acidosis, to severe conditions, such as respiratory failure and restrictive disease. This review
aims to offer an overview of the principal IEMs with neurologic and respiratory involvement,
highlighting the significance of early recognition and multidisciplinary management for optimal
patient care.
Factors Associated with Posttraumatic Stress Disorder in Adolescents Experiencing Earthquake Trauma
Authors: Özgün Öztürk Fatma
Published: June 2024

Introduction:

Posttraumatic Stress Disorder (PTSD) is a prevalent
psychological response among those who survive earthquakes.

Objective:

This study investigates the relationships between sociodemographic
and clinical differences and symptoms of avoidance, re-experiencing, and
hyperarousal, which are key indicators of PTSD in adolescents.

Method:

Research data were collected through online surveys using a simple
random sampling method. The sample group consisted of 178 adolescents who
met the inclusion criteria. Data were collected using the Personal Information
Form (PIF) and the Posttraumatic Stress Disorder Symptoms Scale-Self-Report
Scale (PSS-SR) for Children.

Results:

Of the participants, 77% were female, with a mean age of 16.99. A total
of 84.3% lived with their families. The rate of those trapped under debris during
the earthquake was 97.2%. During the earthquake, 84.8% of adolescents were
injured, and 25.8% lost a family member due to the earthquake. Female
participants showed significantly higher total trauma, re-experiencing, and
hyperarousal scores than males (p<0.05). Those physically injured during the
earthquake had significantly lower total trauma and avoidance scores compared
to those not injured (p<0.05). Participants who lost a family member during the
earthquake had significantly lower total trauma, re-experiencing, and
hyperarousal scores compared to those who did not lose a family member
(p<0.05).

Conclusion:

Females exhibited more PTSD symptoms compared to males. Those
not injured or who did not lose a family member during the earthquake showed
more PTSD symptoms than those who experienced injury or loss.
Participación de mujeres en gabinetes ministeriales de presidentas elegidas democráticamente en América Latina
Authors: Camargo Mayorga David Andrés , Ruiz Acosta Liliana Elizabeth , Lara Bernal Wilson
Published: June 2024

Introduction: There are State policies that can contribute to increasing the participation of women in public life, one of which is the gender quotas implemented by some countries in this century. The idea that women and men have the same capacityto occupy leadership positions deserves a study of the conditions in which they access management positions. Objective: To describe the participation of women in the ministerial cabinets of the six democratically elected presidents in Latin America. Methodology: Qualitative-descriptive, based on documentary analysis. Results:The ministerial cabinets described were characterized by a relatively low presence of women, with high participation as in the case of Costa Rica, and low in Nicaragua. In addition, it was found that the duration of the ministers in their positions on average wasshort and that the ministries in which they were appointed are mostly not the ones with the greatest visibility and importance due to their performance. Conclusions: Female participation in female presidents’ cabinets was relatively weak due to the preferencethat continues to exist for male leaders.