bluuebunny/crossref_metadata_2025 huggingface dataset:
Author Correction: Triple-negative invasive breast carcinoma: the association between the sonographic appearances with clinicopathological feature
Authors: Li Jia-wei , Zhang Kai , Shi Zhao-ting , Zhang Xun , Xie Juan , Liu Jun-ying , Chang Cai
Published: March 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Cutaneous optical coherence tomography for longitudinal volumetric assessment of intradermal volumes in a mouse model
Authors: Schuetzenberger Kornelia , Pfister Martin , Messner Alina , Garhöfer Gerhard , Hohenadl Christine , Pfeiffenberger Ulrike , Schmetterer Leopold , Werkmeister René M.
Published: March 2020

Clinical evaluation of skin lesions requires precise and reproducible technologies for their qualitative and quantitative assessment. In this study, we investigate the applicability of a custom-built dermatologic OCT system for longitudinal assessment of intradermal volumes in a mouse model. The OCT, based on an akinetic swept laser working at 1310 nm was employed for visualization and quantification of intradermal deposits of three different hyaluronic acid-based hydrogel formulations – one commercial and two test substances. Hydrogels were applied in 22 BALB/c mice, and measurements were performed over a six-month time period. All hydrogels increased in volume within the first weeks and degraded steadily thereafter. The half-lifes of the test hydrogels (27.2 ± 13.6 weeks for Hydrogel 1, 31.5 ± 17.2 weeks for Hydrogel 2) were higher in comparison to the commercially available HA hydrogel (21.4 ± 12.0 weeks), although differences were not significant. The sphericity parameter was used for evaluation of the deposit geometry. While on the injection day the sphericities were similar (~0.75 ± 0.04), at later time points significant differences between the different test substances were found (T24: PRV 0.59 ± 0.09, Hydrogel 1 0.70 ± 0.11, Hydrogel 2 0.78 ± 0.07; p ≤ 0.012 for all pairs). This study shows the applicability of OCT imaging for quantitative assessment of the volumetric behavior of intradermal deposits in vivo.
Publisher Correction: Tunable long persistent luminescence in the second near-infrared window via crystal field control
Authors: Nie Jianmin , Li Yang , Liu Shanshan , Chen Qiuqun , Xu Qi , Qiu Jianrong
Published: March 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: Identification of novel dysregulated key genes in Breast cancer through high throughput ChIP-Seq data analysis
Authors: Raj Utkarsh , Aier Imlimaong , Semwal Rahul , Varadwaj Pritish Kumar
Published: March 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Full-waveform inversion imaging of the human brain
Authors: Guasch Lluís , Calderón Agudo Oscar , Tang Meng-Xing , Nachev Parashkev , Warner Michael
Published: March 2020

Magnetic resonance imaging and X-ray computed tomography provide the two principal methods available for imaging the brain at high spatial resolution, but these methods are not easily portable and cannot be applied safely to all patients. Ultrasound imaging is portable and universally safe, but existing modalities cannot image usefully inside the adult human skull. We use in silico simulations to demonstrate that full-waveform inversion, a computational technique originally developed in geophysics, is able to generate accurate three-dimensional images of the brain with sub-millimetre resolution. This approach overcomes the familiar problems of conventional ultrasound neuroimaging by using the following: transcranial ultrasound that is not obscured by strong reflections from the skull, low frequencies that are readily transmitted with good signal-to-noise ratio, an accurate wave equation that properly accounts for the physics of wave propagation, and adaptive waveform inversion that is able to create an accurate model of the skull that then compensates properly for wavefront distortion. Laboratory ultrasound data, using ex vivo human skulls and in vivo transcranial signals, demonstrate that our computational experiments mimic the penetration and signal-to-noise ratios expected in clinical applications. This form of non-invasive neuroimaging has the potential for the rapid diagnosis of stroke and head trauma, and for the provision of routine monitoring of a wide range of neurological conditions.
Two-dimensional amine and hydroxy functionalized fused aromatic covalent organic framework
Authors: Mahmood Javeed , Ahmad Ishfaq , Jung Minbok , Seo Jeong-Min , Yu Soo-Young , Noh Hyuk-Jun , Kim Young Hyun , Shin Hyung-Joon , Baek Jong-Beom
Published: March 2020

Ordered two-dimensional covalent organic frameworks (COFs) have generally been synthesized using reversible reactions. It has been difficult to synthesize a similar degree of ordered COFs using irreversible reactions. Developing COFs with a fused aromatic ring system via an irreversible reaction is highly desirable but has remained a significant challenge. Here we demonstrate a COF that can be synthesized from organic building blocks via irreversible condensation (aromatization). The as-synthesized robust fused aromatic COF (F-COF) exhibits high crystallinity. Its lattice structure is characterized by scanning tunneling microscopy and X-ray diffraction pattern. Because of its fused aromatic ring system, the F-COF structure possesses high physiochemical stability, due to the absence of hydrolysable weak covalent bonds.
Decoration of In nanoparticles on In2S3 nanosheets enables efficient electrochemical reduction of CO2
Authors: Yuan Xin , Luo Yantao , Zhang Bin , Dong Changxue , Lei Jia , Yi Facheng , Duan Tao , Zhu Wenkun , He Rong
Published: March 2020

Decorating the In2S3 nanosheets with in situ formed In nanoparticles boosted the CO2 electroreduction.
Reactivity of boraguanidinato germylenes toward carbonyl compounds and isocyanides: C–O, C–F and C–N bond activation
Authors: Böserle Jiří , Jambor Roman , Růžička Aleš , Erben Milan , Dostál Libor
Published: March 2020

The titled germylene was shown to be able to activate various chemical bonds (C–N, C–F or CO) depending on the substrate used.
Technoproductive evaluation of the energyless microbial-integrated diffusion dialysis technique for acid mine drainage valorization
Authors: Hegab Hanaa M. , ElMekawy Ahmed , Saint Christopher , Banat Fawzi , Hasan Shadi W. , Pant Deepak
Published: March 2020

Acid mine drainage (AMD) presents severe ecological pollution challenges because of its extreme acidity and sulphate and toxic metal contents.
The protective mechanism ofLactobacillus plantarumFZU3013 against non-alcoholic fatty liver associated with hyperlipidemia in mice fed a high-fat diet
Authors: Chen Min , Guo Wei-Ling , Li Qiu-Yi , Xu Jia-Xin , Cao Ying-Jia , Liu Bin , Yu Xiao-Dan , Rao Ping-Fan , Ni Li , Lv Xu-Cong
Published: March 2020

Lactobacillus plantarumFZU3013, isolated from the traditional brewing process ofHongqurice wine, has beneficial effects on improving lipid metabolism disorders.
Design of hydroxyapatite bioceramics with micro-/nano-topographies to regulate the osteogenic activities of bone morphogenetic protein-2 and bone marrow stromal cells
Authors: Li Xiangfeng , Liu Minjun , Chen Fuying , Wang Yuyi , Wang Menglu , Chen Xuening , Xiao Yumei , Zhang Xingdong
Published: March 2020

Biomimicking the nanostructure of natural bone apatite to enhance the bioactivity of hydroxyapatite (HA) biomaterials is an eternal topic in the bone regeneration field.
Efficiency-enhanced and sidelobe-suppressed super-oscillatory lenses for sub-diffraction-limit fluorescence imaging with ultralong working distance
Authors: Li Wenli , He Pei , Yuan Weizheng , Yu Yiting
Published: March 2020

Customized efficiency-enhanced and sidelobe-suppressed super-oscillatory lenses for sub-diffraction-limit fluorescence imaging with ultralong working distances without photobleaching and a pinhole filter.
Completing the triad: synthesis and full characterization of homoleptic and heteroleptic carbonyl and nitrosyl complexes of the group VI metals
Authors: Bohnenberger Jan , Schmitt Manuel , Feuerstein Wolfram , Krummenacher Ivo , Butschke Burkhard , Czajka Jakub , Malinowski Przemysław J. , Breher Frank , Krossing Ingo
Published: March 2020

The triad of group VI metalloradicals is now finally accessible via the oxidation of Cr/Mo/W(CO)6 with the synergistic oxidative system Ag[F-{Al(ORF)3}2]/0.5 I2.
Improving resolving ability of expansion microscopy by varying crosslinker concentration
Authors: Hu Yanlei , Chu Ximing , Chen Ting-ting , Pan Qingshan , Liu Chang , Yi Jintao , Chu Xia
Published: March 2020

Here, we systematically investigated the performance of expansion microscopy (ExM) with different crosslinker concentrations.
Control of the toxic conformation of amyloid β42 by intramolecular disulfide bond formation
Authors: Matsushima Yuka , Yanagita Ryo C. , Irie Kazuhiro
Published: March 2020

An Aβ42 analog crosslinked within the molecule at the 17th and 28th amino acid residues exhibited high aggregative ability and potent neurotoxicity comparable to those of E22P-Aβ42.
Supramolecular lead(ii) architectures engineered by tetrel bonds
Authors: Akbari Afkhami Farhad , Mahmoudi Ghodrat , Qu Fengrui , Gupta Arunava , Köse Muhammet , Zangrando Ennio , Zubkov Fedor I. , Alkorta Ibon , Safin Damir A.
Published: March 2020

The structures, including tetrel bonding, of PbII coordination compounds assembled from N′-(pyridin-2-ylmethylene)picolinohydrazide, N′-(pyridin-2-ylmethylene)nicotinohydrazide and N′-(1-(pyridin-2-yl)ethylidene)isonicotinohydrazide ligands are discussed.
Highly chemically and thermally stable lanthanide coordination polymers for luminescent probes and white light emitting diodes
Authors: Li Qipeng , Qian Jinjie , Zhou Jie , Du Lin , Zhao Qihua
Published: March 2020

A series of isomorphic of highly chemically and thermally stable lanthanide coordination polymers exhibit luminescent probe and warm white-light emission.
The phosphinoboration of acyl chlorides
Authors: Murphy Maia C. , Trofimova Alina , LaFortune James H. W. , Vogels Christopher M. , Geier Stephen J. , Binder Justin F. , Macdonald Charles L. B. , Stephan Douglas W. , Westcott Stephen A.
Published: March 2020

This investigation examines the reactivity of phosphinoboronate esters Ph2PBpin (pin = 1,2-O2C2Me4) and Ph2PBcat (cat = 1,2-O2C6H4), as well as other phosphinoboron species, with various aryl and aliphatic acyl chlorides.
Eutectic hardener from food-based chemicals to obtain fully bio-based and durable thermosets
Authors: Tellers Jonathan , Willems Philippe , Tjeerdsma Bôke , Guigo Nathanael , Sbirrazzuoli Nicolas
Published: March 2020

This paper presents a facile strategy to activate citric acid (CA) for room temperature curing.
Self-responsive co-delivery system for remodeling tumor intracellular microenvironment to promote PTEN-mediated anti-tumor therapy
Authors: Wang Yifei , Wang Ruiting , Wu Sixuan , An Jingyi , Liang Yan , Hou Lin , Zhang Zhenzhong
Published: March 2020

Delivering the pten gene into tumor cells to reacquire PTEN functionality is considered to be an attractive method for cancer treatment.
A generalized strategy for synthesizing crystalline bismuth-containing nanomaterials
Authors: Zhang Liping , Gonçalves Alexandre A. S. , Jiang Baojiang , Jaroniec Mietek
Published: March 2020

Bismuth oxide and its derivatives are promising materials that have applications varying from catalysis to energy-storage devices.
Physical entanglement hydrogels: ultrahigh water content but good toughness and stretchability
Authors: Puza Fatih , Zheng Yijun , Han Lu , Xue Lulu , Cui Jiaxi
Published: March 2020

Physical entanglement of polymer chains is an interaction that is believed to be too weak to build polymer networks for hydrogelation.
Formation of cyclic structures in the cationic ring-opening polymerization of 1,3-dioxolane
Authors: Coenen Anna M. J. , Harings Jules A. W. , Ghazanfari Samaneh , Jockenhoevel Stefan , Bernaerts Katrien V.
Published: March 2020

Elucidating the mechanism of the cationic ring-opening polymerization of dioxolane using gel permeation chromatography, matrix assisted laser desorption/ionization time of flight mass spectrometry and 31P NMR.
Effects of electric field and strain engineering on the electronic properties, band alignment and enhanced optical properties of ZnO/Janus ZrSSe heterostructures
Authors: Vo Dat D. , Vu Tuan V. , Nguyen Thi H. Tham , Hieu Nguyen N. , Phuc Huynh V. , Binh Nguyen T. T. , Idrees M. , Amin B. , Nguyen Chuong V.
Published: March 2020

Here, in this work, we investigate the structural, electronic and optical features of ZnO/ZrSSe vdWHs for different stacking patterns of ZnO/SeZrS and ZnO/SZrSe by employing first-principles calculations.
DP4-AI automated NMR data analysis: straight from spectrometer to structure
Authors: Howarth Alexander , Ermanis Kristaps , Goodman Jonathan M.
Published: March 2020

A robust system for automatic processing and assignment of raw 13C and 1H NMR data DP4-AI has been developed and integrated into our computational organic molecule structure elucidation workflow.
Sterically controlled reductive oligomerisations of CO by activated magnesium(i) compounds: deltate vs. ethenediolate formation
Authors: Yuvaraj K. , Douair Iskander , Jones Dafydd D. L. , Maron Laurent , Jones Cameron
Published: March 2020

Subtle changes to the bulk of 1 : 1 adducts of DMAP with magnesium(i) complexes leads to steric control over the products arising from their reductive oligomerisations of carbon monoxide.
Nano-spatially confined Pd–Cu bimetals in porous N-doped carbon as an electrocatalyst for selective denitrification
Authors: Gu Tianhang , Teng Wei , Bai Nan , Chen Zehan , Fan Jianwei , Zhang Wei-xian , Zhao Dongyuan
Published: March 2020

Nanodenitrification is achieved by bimetallic Pd–Cu nanoparticles encapsulated in porous N-doped carbon as electrocatalysts, with reduced nitrate below drinking water standards and a N2 selectivity as high as 83% in a neutral electrolyte.
Effects of rolling and N-fertilization on dollar spot and Microdochium patch on golf greens in Scandinavia
Authors: Espevig Tatsiana , Usoltseva Marina , Norman Karin
Published: March 2020

Dollar spot was officially documented in Scandinavia in 2013 and the spread and damage from this disease has increased during last years. In summer 2017, on the golf greens with red fescue (Vallda GC, Sweden) and with the mixture of red fescue, colonial bentgrass and annual bluegrass (Roskilde GC, Denmark) rolling 2 times per week reduced dollar spot 61% and 37% and rolling 4 times per week reduced dollar spot 95% and 54%, respectively. Thus, rolling 3-4 times per week can be recommended on golf greens with dollar spot pressure. In the experiment 2018 dollar spot was reduced 24% with increase in nitrogen from 150 to 240 kg ha-1 yr-1 on creeping bentgrass/annual bluegrass golf green (Kävlinge GK, Sweden). However, the increased N-rate lead to a higher degree Microdochium patch from 14% to 30%.
Diaporthe species infecting sunflower in Russia
Authors: Gomzhina Maria , Gannibal Philipp
Published: March 2020

Diaporthe is an important group of plant pathogenic fungi revealed all over the world. Early classification and species identification of this genus was mostly based on combination of morphological characteristics, cultural features, and affiliation with a host plant. According to recent investigations, valid distinction between Diaporthe species should have combined molecular techniques, morphological and cultural observations, and mating type data. In Russia a comprehensive and extensive analysis of biodiversity and geographic distribution of Diaporthe species infecting sunflower has not been performed. There were seven Diaporthe sp. strains isolated from this plant maintained in the Laboratory of Mycology and Phytopathology of All-Russian Institute of Plant Protection. In previous study a strain from Krasnodar region, based on combination of molecular and morphological features was identified as Diaporthe phaseolorum. The aim of this study was to identify all other strains using primarily molecular phylogenetic approach and traditional morphological analysis. The strains were identified as Diaporthe gulyae, Diaporthe eres, and Diaporthe helianthi. Two species - D. gulyae and D. eres are found for the first time on sunflower in Russia. Detection of D. helianthi is the first report of this fungus in Russia as confirmed by molecular analysis.
The distribution of the surface-active beetles (Coleoptera: Carabidae, Staphylinidae, Elateridae) in the agricultural landscapes of Northwestern Russia
Authors: Guseva Olga G. , Koval Alexander G.
Published: March 2020

This paper demonstrates that the species composition of the surface-active beetles (Coleoptera: Carabidae, Staphylinidae, Elateridae) in the landscape site is determined by its local crop. The hygrophilous species are most common in areas with dense vegetation. Assemblages of the epigeic beetles in fields of different crops and adjacent habitats (field margins overgrown with shrubs and forbs) are separated from each other. Beetles associated with a leaf litter layer dominate on the field margins, while rarely occurring in the fields. The populations of the surface-active beetles in perennial grass fields and field margins have the highest species richness.
Biodiversity of beet webworm microsporidia in Eurasia
Authors: Malysh Julia , Tokarev Yuri , Malysh Svetlana , Xingfu Jiang , Frolov Andrei
Published: March 2020

The beet webworm Loxostege sticticalis (LS) has eruptive type of population dynamics and high migratory activity. The LS outbreaks are therefore difficult to predict and the pest belongs to the category of highly dangerous pests. However, during periods of depressions this insect is not observed within the most of its range and is very susceptible to infection by pathogens, including various species of microsporidia, some of which are not specific parasites of the order Lepidoptera. The distribution of LS microsporidia in Eurasia is quite extensive. During the study period of LS from 2003 to 2019, we have found 6 species of microsporidia. The parasite list includes not only species known for Lepidoptera such as Nosema sp. and Vairimorpha thomsoni, but also Vairimorpha (Nosema) ceranae as the typical pathogen from Apis mellifera, as well as Endoreticulatus cf poecilimonae, a pathogen similar to Endoreticulatus poecilimonae from Poecilimon thoracicus. Moreover, two isolates from the genus Tubulinosema identified in LS belong to the group of parasites with a very wide host range, including humans. In laboratory experiments, LS proved high sensitivity to microsporidia N. pyrausta from Ostrinia nubilalis and N. tyriae from Tyria jacobaeae. Its susceptibility to Paranosema locustae from Locusta migratoria has also been discovered.
Biological plant protection in greenhouse, intensive and organic farming
Authors: Pavlyushin Vladimir
Published: March 2020

The scientific schools of All-Russian Institute of Plant Protection offer a new paradigm for the development of plant protection, based on the principles of managing the phytosanitary state of agroecosystems. In recent years, the biological protection of vegetables in greenhouses develops intensively. The assortment of protective biological products are in demand on the domestic market and have proven themselves in bioprotection systems. Given the strict regulatory framework for organic farming and the presence of a wide variety of phytosanitary objects, the phytosanitary risks are of great importance when ecologically safe agricultural products are to be obtained. In intensive crop production, plant protection is largely based upon application of synthetic pesticides. Efforts are aimed at reduction of harm and one of the modern trends is the increase in usage of biological products for treatment of seeds as well as spraying crops during the vegetation season. More biological products are used nowadays and positive results are obtained.
Vaux-en-Bugey (Ain, France): the first gas field produced in France, providing learning lessons for natural hydrogen in the sub-surface?
Authors: Deronzier Jean-François , Giouse Hélène
Published: March 2020

The former Vaux-en-Bugey field, first French methane production from early 20th century, is revisited as a case study to address the present generation and accumulation theories for gases like hydrogen and helium. The volume of the initial gas in place is estimated to be 22 million m3. Based on a composition of 5% of hydrogen and 0.096% of helium, the volumes of these gases in the field were respectively around 1.1 million m3for hydrogen and 24 000 m3for helium. The different hypotheses of hydrogen sources are reviewed: serpentinization, hydro-oxidation of siderite, water radiolysis, bio-fermentation, mechanical generation, degassing from depth trough faults, steel corrosion. For helium generation, the different sources of radioactive minerals and intermediate accumulations are examined. The most probable scenario is the hydrogen production by water radiolysis and helium production by radioactive decay in or near the basement, migrating trough deep faults, stored and concentrating in an aquifer with thermogenic methane, then flushed by methane into the gas field, during Jura thrusting. New measurements with portable gas detector, incomplete but including hydrogen, on a former exploration well with accessible flux of gas, give the opportunity to comment gas saturation evolution more than a century after the 1906 discovery. The decreasing of hydrogen content since the discovery of the field is probably due to Sulphate-Reducing Bacteria activity.
Regionale Pflichtversorgung in der stationären Psychiatrie und Psychotherapie
Authors: Ziereis Michael , Günther Stefan , Baghai Thomas C. , Rupprecht Rainer
Published: March 2020

Gegenstand und Ziel Die vorliegende Studie zeigt einen alternativen Weg zur Operationalisierung des Begriffs „regionale Pflichtversorgung“ in der stationären Psychiatrie und Psychotherapie auf.

Material und Methoden In einer explorativen Analyse von 9659 Behandlungsfällen von psychiatrischen Fachabteilungen an 3 Standorten wurden aus Routinedaten gewonnene Kennzahlen hinsichtlich ihrer Eignung zur Abbildung des Begriffs untersucht.

Ergebnisse Im Abgleich mit einem Expertenrating konnten hohe Übereinstimmungswerte vor allem bei denjenigen Parametern gefunden werden, die den Aspekt der Vollversorgung („Diagnosespektrum“), der Notfallversorgung („Aufnahmezeit“) und den Aspekt der Versorgungsleistung in der Region („Hauptversorgungsgebiet“) abbilden.

Schlussfolgerung Als Vorteile der Methodik werden die aufwandsneutrale Erhebungs- und Überprüfungsmechanismen sowie die vergleichsweise hohe Objektivität und Reliabilität der generierten Kennzahlen gesehen. Zudem eröffnet dieses Vorgehen die Perspektive einer Generalisierbarkeit des Begriffs der Pflichtversorgung auf andere Fachabteilungen ohne die psychiatriespezifische Besonderheit der gerichtlichen Unterbringung. Aufgrund der geringen Anzahl der betrachteten Standorte bedarf es jedoch zwingend weiterer konfirmatorischer, multizentrischer Untersuchungen.

Klinische Relevanz Ziel kann dabei die Generierung eines Komplexindex sein, welcher eine valide Abbildung des Konstrukts „regionale Pflichtversorgung“ erlaubt und damit die Basis für eine adäquate und leistungsgerechte Ressourcenzuweisung an die Kliniken vor dem Hintergrund der gesundheitspolitischen Bestrebungen für eine Neuordnung der Personalbemessung in den entsprechenden Fachgebieten schafft.
Wirksamkeit von Disease-Management-Programmen für Asthma und COPD? Ergebnisse einer Querschnittstudie
Authors: Kanniess F. , Krockenberger K. , Oepen P. , Hedrich R. , Olbrich D. , Hessler N. , Ziegler A. , Langer-Brauburger B.
Published: March 2020

Einleitung Die Wirksamkeit der deutschen Disease-Management-Programme (DMP) Asthma und chronisch obstruktive Lungenerkrankung (COPD) kann mit den gesetzlich vorgeschriebenen Dokumentationen nicht gezeigt werden. Studien mit Vergleichsgruppen sind selten. Ziel war es, in einer Querschnittstudie zu untersuchen, ob sich die Krankheitskontrolle bei Teilnehmern (DMP+) und Nicht-Teilnehmern (DMP–) der DMP Asthma und COPD voneinander unterscheidet.

Methoden Die Studie ist eine prospektive, multizentrische Querschnittstudie, die untersucht, inwieweit DMP+-Patienten sich von entsprechenden DMP–-Patienten im Hinblick auf ihre Krankheitskontrolle voneinander unterscheiden. Primärer Endpunkt war die Krankheitskontrolle, gemessen mit dem Asthma-Control-Test™ (ACT) im Studienteil Asthma sowie dem COPD-Assessment-Test™ (CAT) im Studienteil COPD.

Ergebnisse Insgesamt wurden 1038 Asthma-Patienten und 846 COPD-Patienten eingeschlossen, je mit etwa 70 % DMP-Teilnehmern. Der ACT-Score war bei den Asthma-DMP+-Patienten höher als bei den DMP– -Patienten (Mittelwertdifferenz 0,86; 95 % KI: 0,29 – 1,43; p = 0,003), allerdings klinisch nicht relevant. Bei COPD-Patienten fand sich ebenfalls kein klinisch relevanter Unterschied in der Krankheitskontrolle (0,52; 95 % KI: – 0,71 – 1,75; p = 0,405). Nur etwa 60 % der Patienten, die seit mindestens einem Jahr in das entsprechende DMP eingeschrieben waren, hatten an einer strukturierten Schulung teilgenommen. Zwischen geschulten und nicht geschulten Patienten fand sich kein Unterschied in der Krankheitskontrolle.

Diskussion Es fand sich kein klinisch relevanter Unterschied in der Krankheitskontrolle zwischen DMP+ - und DMP– -Patienten für die DMP Asthma und COPD. International wurde die Wirksamkeit von DMP bei Asthma und COPD in randomisierten Studien nachgewiesen. Auch in Deutschland sollten randomisierte Studien durchgeführt werden, um die Wirksamkeit der DMP Asthma und COPD zu belegen.

Registrierung drks.de, DRKS00007664, Registrierungsdatum: 15.01.2015
Duplicate Prescriptions of Inhaled Medications for Obstructive Lung Diseases
Authors: Kardos P. , Geiss F. , Simon J. , Franken C. , Butt U. , Worth H.
Published: March 2020

Introduction Inhalative treatments with metered dose aerosols and dry powder inhalers are the backbone of the pharmacotherapy for asthma and COPD. In the last decade many new and generic inhalative bronchodilators were launched at the German market, both monotherapies and fixed dose double bronchodilator (LABA/LAMA, beta adrenergic and antimuscarinic) or LABA and inhaled corticosteroid (ICS) and triple (LABA/LAMA/ICS) combinations. According to two surveys in 2015 among respiratory physicians we expected a high proportion of patients receiving duplicate prescriptions, e. g. a fixed dose new LABA/LAMA combination in addition to an existing ICS/LABA fixed dose combination.

Methodology We searched the database of a large mail order pharmacy (DocMorris) to identify duplicate prescriptions of inhalative drugs for a patient by the same or by two or more different physicians during a 3 months period.

Results Unexpectedly, we found as little as around 1 % duplicate prescriptions for the same patient. Duplicate prescriptions involving combination products were found to be much more common than duplicate prescriptions of different mono-products. Irrespective the low percentage number of all prescriptions we saw in just one large mail order pharmacy several thousands of erroneous prescriptions.

Conclusion At least in the setting of this mail order pharmacy duplicate (i. e. contraindicated and potentially dangerous) prescriptions are relatively rare. Prescribers and pharmacists should be aware of the issue of duplicates – especially when prescribing or filling prescriptions with combination products.
Expanding the Spectrum of Neurological Manifestations in Cutis Laxa, Autosomal Recessive, Type IIIA
Authors: Angelini Chloé , Thibaud Marie , Aladjidi Nathalie , Bessou Pierre , Cabasson Sébastien , Colson Cindy , Espil-Taris Caroline , Goizet Cyril , Husson Marie , Morice-Picard Fanny , De Sandre-Giovannoli Annachiara , Pédespan Jean-Michel
Published: March 2020

Cutis laxa is a heterogeneous group of diseases, characterized by abundant and wrinkled skin and a variable degree of intellectual disability. Cutis laxa, autosomal recessive, type IIIA and autosomal dominant 3 syndromes are caused by autosomal recessive or de novo pathogenic variants in ALDH18A1. Autosomal recessive variants are known to lead to the most severe neurological phenotype, and very few patients have been described.

We describe a 13-month-old patient with cutis laxa, autosomal recessive, type IIIA, with an extremely severe phenotype, including novel neurological findings. This description enlarges the neurological spectrum associated to cutis laxa, autosomal recessive, type IIIA, and provides an additional description of this syndrome.
The Postoperative Pancreas Imaging
Authors: Taher Ahmed , Mujtaba Bilal , Ramani Nisha S. , Patel Asif , Morani Ajaykumar C.
Published: March 2020

Recent advances in the surgical techniques and postoperative intensive care have led to a decrease in the mortality rates after major pancreatic procedures, which now ranges from 1 to 3%. However, the morbidity rates are still high, resulting in longer hospital stays and greater cost. Imaging plays a fundamental role in the postoperative assessment. Specially, multidetector computed tomography scans (MDCT) is the modality of choice in the postoperative settings. Early diagnosis of the postoperative complications and differentiating them from being normal or expected postoperative findings is crucial to offer the best possible care for patients and to decrease the morbidity and mortality associated with surgery. In this article, we will briefly review the normal pancreatic anatomy, discuss the main types of pancreatic surgeries, and illustrate the imaging findings during the early postoperative period and of the main postsurgical complications in both acute and chronic postoperative settings.
Comparison of Periarticular Infiltration and Combination Delivery of Local Anesthetics for Reducing Pain and Opioid Consumption after Total Knee Arthroplasty
Authors: Ward Derek T. , Grotkopp Eva , Detch Robert C. , Kim Hubert T. , Kuo Alfred C.
Published: March 2020

Surgical-site delivery of local anesthetics decreases pain and opioid consumption after total knee arthroplasty (TKA). The optimal route of administration is unknown. We compared local anesthetic delivery using periarticular soft-tissue infiltration to delivery using a combination of preimplantation immersion and intra-articular injection (combination treatment). The records of patients who underwent unilateral, cemented, primary TKA with spinal anesthesia and adductor canal blocks at a single Veterans Affairs Medical Center were retrospectively reviewed. Three subgroups were compared, including controls who did not receive additional local anesthetics, patients who received periarticular infiltration, and patients who received combination treatment. Mean daily pain scores and mean 24-hour opioid consumption on postoperative days (PODs) 0 and 1 were calculated, and analysis of variance was used to assess for significant differences. Factors that were associated with lower pain scores and opioid consumption were then identified using multivariate stepwise regression. There were 26 controls, 25 periarticular infiltration patients, and 39 combination patients. The periarticular infiltration cohort had significantly lower mean pain scores and opioid consumption than controls on POD 0, but not on POD 1. The combination cohort had significantly lower mean pain scores and opioid consumption than controls on PODs 0 and 1. There were no significant differences between the infiltration and combination groups on either day. Multivariate regression analysis showed that infiltration was associated with significantly decreased opioid consumption on both days and decreased pain on POD 0. Combination treatment was associated with significantly decreased pain and opioid consumption on both days. Both local anesthetic periarticular infiltration and combination treatment are associated with decreased pain and opioid consumption after TKA. The stronger effects of the combination treatment compared with periarticular infiltration on POD 1 suggests that combination delivery may have a longer duration of action.
Acute Flaccid Myelitis: A Clinical Review
Authors: Murphy Olwen C. , Pardo Carlos A.
Published: March 2020

Acute flaccid myelitis (AFM) is an emerging disorder primarily affecting children that is characterized by acute flaccid paralysis accompanied by abnormalities of the spinal cord gray matter on magnetic resonance imaging. In most cases, prodromal fever or respiratory symptoms occur, followed by acute-onset flaccid limb weakness. Respiratory, axial, bulbar, facial, and extraocular muscles may also be affected. The clinical manifestations have been described as “polio-like,” due to striking similarities to cases of poliomyelitis. The primary site of injury in AFM is the anterior horn cells of the spinal cord, resulting in a motor neuronopathy. Seasonal peaks of cases have occurred in the United States every 2 years since 2012. However, AFM remains a rare disease, which can make it challenging for physicians to recognize and differentiate from other causes of acute flaccid paralysis such as Guillain–Barre syndrome, spinal cord stroke, and transverse myelitis. Epidemiological evidence suggests that AFM is linked to a viral etiology, with nonpolio enteroviruses (in particular enterovirus D68) demonstrating a plausible association. The epidemiology, possible etiological factors, clinical features, differential diagnosis, treatment, and outcomes of AFM are discussed in this review.
The Effect of Antenatal Neuroprotective Magnesium Sulfate Treatment on Cerebral Oxygenation in Preterm Infants
Authors: Ozer Bekmez Buse , Oğuz Yüksel , Kutman Hayriye Gözde Kanmaz , Uygur Dilek , Canpolat Fuat Emre , Oğuz Serife Suna , Tayman Cüneyt
Published: March 2020

Objective Antenatal magnesium sulfate (MgSO4) treatment is associated with reduced risk of cerebral palsy in preterm infants. We aimed to investigate whether this treatment leads to any alterations on cerebral hemodynamics which could be detected by near-infrared spectroscopy (NIRS) readings in early postnatal life.

Study Design Infants with gestational ages (GAs) ≤ 32 weeks were divided into two groups regarding their exposure to antenatal neuroprotective MgSO4 treatment or not. NIRS monitoring was performed to all infants, and readings were recorded for 2 hours each day during the first 3 days of life. The primary aim was to compare regional cerebral oxygen saturation (rcSO2) and cerebral fractional tissue oxygen extraction (cFTOE) between the groups.

Results Sixty-six infants were exposed to antenatal MgSO4, while 64 of them did not. GA and birth weight were significantly lower in the treatment group (p < 0.01). No difference was observed in rcSO2 and cFTOE levels in the first, second, and the third days of life (p > 0.05). An insignificant reduction in severe intraventricular hemorrhage rates was observed (8 vs. 15%, p = 0.24).

Conclusion We could not demonstrate any effect on cerebral oxygenation of preterm infants in early postnatal life that could be attributed to antenatal neuroprotective MgSO4 treatment. Future studies are warranted to clarify the exact underlying mechanisms of neuroprotection.
Acute Necrotizing Encephalopathy of Childhood with H1N1 Infection
Authors: Takia Lalit , Patra Nilamani , Nallasamy Karthi , Saini Lokesh , Suthar Renu , Angurana Suresh K. , Jayashree Muralidharan
Published: March 2020

Acute necrotizing encephalopathy of childhood (ANEC) is an uncommon and fulminant complication of seasonal influenza infection associated with high mortality and poor neurological outcome. We report a 4.5-year-old female who had pneumonia, ANEC, and raised intracranial pressure (ICP) with polymerase chain reaction proven H1N1 infection. Management included mechanical ventilation, invasive monitoring and control of ICP, oseltamivir, methylprednisolone, and supportive care in pediatric intensive care unit. She survived with poor neurological status at discharge.
Microfluidic platform for three-dimensional cell culture under spatiotemporal heterogeneity of oxygen tension
Authors: Koens Rei , Tabata Yugo , Serrano Jean C. , Aratake Satoshi , Yoshino Daisuke , Kamm Roger D. , Funamoto Kenichi
Published: March 2020

Cells in a tumor microenvironment are exposed to spatial and temporal variations in oxygen tension due to hyperproliferation and immature vascularization. Such spatiotemporal oxygen heterogeneity affects the behavior of cancer cells, leading to cancer growth and metastasis, and thus, it is essential to clarify the cellular responses of cancer cells to oxygen tension. Herein, we describe a new double-layer microfluidic device allowing the control of oxygen tension and the behavior of cancer cells under spatiotemporal oxygen heterogeneity. Two parallel gas channels were located above the media and gel channels to enhance gas exchange, and a gas-impermeable polycarbonate film was embedded in the device to prevent the diffusion of atmospheric oxygen. Variations in oxygen tension in the device with the experimental parameters and design variables were investigated computationally and validated by using oxygen-sensitive nanoparticles. The present device can generate a uniform hypoxic condition at oxygen levels down to 0.3% O2, as well as a linear oxygen gradient from 3% O2 to 17% O2 across the gel channel within 15 min. Moreover, human breast cancer cells suspended in type I collagen gel were introduced in the gel channel to observe their response under controlled oxygen tension. Hypoxic exposure activated the proliferation and motility of the cells, which showed a local maximum increase at 5% O2. Under the oxygen gradient condition, the increase in the cell number was relatively high in the central mild hypoxia region. These findings demonstrate the utility of the present device to study cellular responses in an oxygen-controlled microenvironment.
Microfluidic single-cell analysis—Toward integration and total on-chip analysis
Authors: Fung Cheuk Wang , Chan Shek Nga , Wu Angela Ruohao
Published: March 2020

Various types of single-cell analyses are now extensively used to answer many biological questions, and with this growth in popularity, potential drawbacks to these methods are also becoming apparent. Depending on the specific application, workflows can be laborious, low throughput, and run the risk of contamination. Microfluidic designs, with their advantages of being high throughput, low in reaction volume, and compatible with bio-inert materials, have been widely used to improve single-cell workflows in all major stages of single-cell applications, from cell sorting to lysis, to sample processing and readout. Yet, designing an integrated microfluidic chip that encompasses the entire single-cell workflow from start to finish remains challenging. In this article, we review the current microfluidic approaches that cover different stages of processing in single-cell analysis and discuss the prospects and challenges of achieving a full integrated workflow to achieve total single-cell analysis in one device.
Detailed isofield calorimetry of La(Fe,Si,Mn)H reveals distributed magnetocaloric phase transitions
Authors: Erbesdobler F. , Bahl C. R. H. , Bjørk R. , Nielsen K. K.
Published: March 2020

We show that low ramp rate differential scanning calorimetry of the magnetocaloric material La(Fe11.47Si1.28Mn0.25)H1.65 at different applied magnetic fields reveals the presence of distributed phase transitions. Experimentally, we find that with or without an applied magnetic field, samples show a distinct peak pattern in their heat capacity around the transition temperature (Tt≈30°C), i.e., multiple heat capacity peaks occur as a function of sample temperature. Additionally, these reproducible patterns occur asymmetrically when heating and cooling. At finite applied fields higher than 0.15 T, we observe clearly distinguishable peaks of identical shape, albeit with different intensities. According to the latter, we re-identify the peaks under seven applied magnetic fields up to 1 T. We find that the peaks shift differently relative to each other as a function of field. In particular, for cooling experiments, the peak temperatures vary linearly in the field, although with different slopes. Through Bean–Rodbell (BR) modeling, we show that the experimentally observed behavior can be simulated by small decoupled variations in the BR parameters η and T0, indicating a distributed composition of the magnetocaloric material.
Micro-magnetic simulations of correlated switching in touching circular nano-magnetic elements
Authors: Durowade Tejumade , Metlushko Vitali
Published: March 2020

Past studies have demonstrated that logic states can be represented using the rotation of the magnetization at flux-closed remanence in individual ferromagnetic disks. In this work, we present the results of micro-magnetic simulations of touching circular elements that can be used for room operable magnetic quantum cellular automata. Like gears in a mechanical system, the chirality of the magnetization alternates from element to element, as determined through interaction with neighbors. The switching of touching symmetric elements occurred when the applied field was removed, meaning minimal energy loss during the process. Maintaining coherence of opposite chirality in chains of elements could be achieved with the introduction of a biasing element to eliminate the bidirectionality of interaction.
CAVIAR: A simulation package for charged particles in environments surrounded by conductive boundaries
Authors: Biagooi Morad , Samanipour Mohammad , Ghasemi S. Alireza , Nedaaee Oskoee SeyedEhsan
Published: March 2020

We introduce CAVIAR, new scientific software that is developed for molecular simulation of ionic-liquids or charged colloids inside conductive boundaries. CAVIAR imports computer-aided-design geometries and uses them to simulate boundary walls. Then based on this geometry, a finite element mesh is generated and utilized for solving the Poisson equation. To avoid the complexity due to the singularity of point charges, we propose a new method, using the advantages of the superposition theorem of the linear partial differential equations. Within this paper, the CAVIAR structure, its features, and basic scientific algorithms are discussed.
O-band N-rich silicon nitride MZI based on GST
Authors: Faneca Joaquin , Bucio Thalía Domínguez , Gardes Frederic Y. , Baldycheva Anna
Published: March 2020

We have experimentally demonstrated an O-band Mach–Zehnder interferometer (MZI) based on an N-rich silicon nitride platform combined with Ge2Sb2Te5 for future optical communication applications. The device operation relies on controlling the waveguide's losses using a phase change material cell, which can be changed from amorphous (low-loss) to crystalline (high-loss). An extinction ratio as high as 11 dB was obtained between the amorphous (ON) and the crystalline (OFF) states of the MZI optical building block. The insertion loss of the MZI structure per cell unit length was measured to be as high as 0.87 dB/μm in the OFF state and as low as 0.064 dB/μm in the ON state for TM polarization.
Phase-field simulation of magnetic field induced microstructure evolution in γMn-based alloys
Authors: Cui Shushan , Wan Jianfeng , Chen Nailu , Rong Yonghua
Published: March 2020

γMn-based alloys mainly possess an antiferromagnetic martensitic structure at room temperature, in which the type of crystal structure changes with the magnetic structure. Therefore, it is commonly believed that the cubic–tetragonal structural transformation is caused by the magnetic transition. Due to small transformation distortion and high magnetic field being required to present strong magnetism, the microstructure evolution of γMn-based alloys under an external magnetic field has rarely been experimentally revealed. In this paper, a phase-field model based on the related antiferromagnetic energies is proposed to investigate the microstructure evolution during magnetization. The simulated results show that the microstructure after martensitic transformation exhibits a self-accommodated twinning pattern. Upon magnetic loading, two transition stages, i.e., the reorientation stage of antiferromagnetic domains and the antiferromagnetic–ferromagnetic transition stage, would successively appear. External stress directly affects the relative stability among martensitic variants, thereby indirectly influencing the magnetization behavior, and the effect is related to the stress direction. Although the microstructure changes with the external condition, the interfacial migration of martensitic variant domain (or the martensitic twin boundary) and magnetic domain could keep in accordance with each other due to the strong magnetoelastic coupling.
Viscosity measurements of high-pressure liquids via a quartz crystal fundamental resonance
Authors: Yamawaki Hiroshi
Published: March 2020

The pressure dependence of liquid viscosity for several liquids was obtained from the ΔΓ method using the bandwidth of the fundamental resonance peak of a quartz crystal resonator. The fundamental mode and the third overtone of the resonator in methyl laurate were determined and then compared to the square root of the viscosity–density product (ηρ) from the resonance frequency and bandwidth. The ηρ values obtained from the bandwidth of the fundamental mode were consistent with those obtained from other methods. The ΔΓ method could be applied to high-viscosity regions of bis(2-ethylhexyl) sebacate, using the relationship between ηρ and ΔΓ obtained from reference liquids at atmospheric pressure. The pressure dependence was obtained for methyl oleate viscosity up to 320 MPa; it is the major component of biodiesel fuel. In addition, the viscosity pressure dependence was obtained by the ΔΓ method from the fundamental mode in methanol and 1-pentanol that was previously measured up to 700 MPa with a smaller resonator.
Short- and long-term memory functions are mimicked through artificial synapse
Authors: Mandel Savannah
Published: March 2020

Researchers find biological short- and long-term memory mechanisms can be imitated in neural networks using precise engineering of magnetic tunnel junction stacks.
Deep learning speeds up video compressive sensing from days to minutes
Authors: Mandel Savannah
Published: March 2020

Researchers can recover a video from a single two-dimensional image within tens of milliseconds (or sub-seconds), thanks to deep learning.
MicroRNAs organize intrinsic variation into stem cell states
Authors: Chakraborty Meenakshi , Hu Sofia , Visness Erica , Del Giudice Marco , De Martino Andrea , Bosia Carla , Sharp Phillip A. , Garg Salil
Published: March 2020

Pluripotent embryonic stem cells (ESCs) contain the potential to form a diverse array of cells with distinct gene expression states, namely the cells of the adult vertebrate. Classically, diversity has been attributed to cells sensing their position with respect to external morphogen gradients. However, an alternative is that diversity arises in part from cooption of fluctuations in the gene regulatory network. Here we find ESCs exhibit intrinsic heterogeneity in the absence of external gradients by forming interconverting cell states. States vary in developmental gene expression programs and display distinct activity of microRNAs (miRNAs). Notably, miRNAs act on neighborhoods of pluripotency genes to increase variation of target genes and cell states. Loss of miRNAs that vary across states reduces target variation and delays state transitions, suggesting variable miRNAs organize and propagate variation to promote state transitions. Together these findings provide insight into how a gene regulatory network can coopt variation intrinsic to cell systems to form robust gene expression states. Interactions between intrinsic heterogeneity and environmental signals may help achieve developmental outcomes.