bluuebunny/crossref_metadata_2025 huggingface dataset:
‘It was quiet’: the radical architectures of understatement in feminist science fiction
Authors: Butt Amy
Published: October 2022

“Poisonless:a bare city, bright, the colours light and hard, the air pure. It was quiet.”

The Dispossessed, Ursula K. Le Guin (1974)

This is how Ursula K. Le Guin describes the city of Abbenay in The Dispossessed. It is modest and unassuming. It is quiet. This architectural restraint is jarringly at odds with predominant portrayals of the science fiction city. As noted by Graham (2016) and Hurley (2008) the future city has become synonymous with rapid vertical urbanisation, closing off alternative urban visions and the possible futures they contain. While there is a growing call for the study of sf by scholars in the spatial disciplines such as Abbott (2016), Collie (2011), Hewitt and Graham (2015) and Kitchin and Kneale (2002), the unassuming, everyday spaces of feminist sf are often lost in the shadows cast by the dystopian high rise. As Le Guin argues, these passive and participatory utopias become visible only when we ‘adjust to a dimmer light’ (1989). In response, this paper lingers in shared spaces of sf which are possible examples of what Washida Imarisha terms ‘visionary fiction’ which is sf that ‘has a relevance towards building new, freer worlds’ (2015: 4) including; N.K. Jemisin’s Broken Earth trilogy (2015–2017), Sally Miller Gearhart’s The Wanderground (1979) and Marge Piercy’s Woman on the Edge of Time (1976). By imaginatively inhabiting the utopian enclaves within these feminist texts it is possible to explore geographies of alterity – to adjust to the dim light and learn to cherish the quiet.
Natural / Disaster: Differential Media Portrayals of Wildfire Displacement and Homelessness in Portland, Oregon
Authors: Cowal Janet , Leickly Emily , Ajibade Idowu , Hines Maude , Knowlton Stefanie , Petteni Marta
Published: October 2022

The devastating 2020 wildfires in Oregon provide an opportunity to revisit the “discursive creation of homelessness” first identified by Céline Pascale in this journal in 2005. Drawing on physical observation of the unfolding event and discursive analysis of media reporting (print, radio, and television), we find radically different media coverage of people unhoused by wildfires and those previously unhoused but also affected by the fires. Journalistic uses of nomenclature and reported speech, portrayals of agency, and exclusion of marginalized voices provide current examples of the stratification of deservedness. The wildfires, deemed a natural disaster but simultaneously an “unnatural” cause of houselessness, reinforced the differential material treatment of “evacuees” as a special category deserving of aid and support in contrast to people living unhoused before the wildfires. Yet this reasoning ignores the temporal dimensions of displacement and lack of housing, which independent of their causes produce compounding and tangible socio-economic and physical effects on those affected. We argue that as climate change-related disasters such as wildfires displace more people in Oregon and across the United States, the origins of houselessness will be less meaningful while societal response and compassion will matter more.
Association of Dementia Severity and Caregiver Support With Early Discharge From Home Health
Authors: Knox Sara , Haas Allen , Downer Brian , Ottenbacher Kenneth J.
Published: October 2022

Introduction

The objective of this study was to examine the relationship between dementia severity and early discharge from home health.

Methods

This was a retrospective study of 100% national Medicare home health da ta files (2016-2017). Multilevel logistic regression was used to study the relationship of dementia severity, caregiver support, and medication assistance with early discharge from home health.

Results

The final cohort consisted of 91 302 Medicare beneficiaries with an ADRD diagnosis. A pattern of early discharge rates across dementia severity levels was not demonstrated. The relative risk for early discharge was lower for individuals who needed assistance with medication and for those with unmet caregiver needs.

Discussion

The findings of this study do not support the hypothesis that dementia severity contributes to early discharge from home health. Further research is needed to fully understand key factors contributing to early discharge from home health.
Thinking Diffractively with Data in Human Resource Development
Authors: Li Beixi
Published: October 2022

Despite growing numbers of qualitative research studies published in human resource development (HRD), there is a limited scope of qualitative methodologies applied. When it comes to qualitative data analysis, coding-based analysis is the go-to analytical method in HRD. This article introduces diffractive analysis, a concept for data analysis that encourages new ways to consider the entanglement between data, theories, researchers, and the researched. This paper introduces the philosophical foundation of diffractive analysis that challenges reflection as the prominent metaphor for inquiry in HRD research and practice. Examples from empirical studies are presented to illustrate how data and theory can be read diffractively into each other to produce different knowledge in HRD. The differences diffractive analysis can potentially make in HRD include engaging with research philosophically, analyzing data diffractively, developing a performative understanding of the field, and strengthening researcher-practitioner partnership.
A Study of Self-Care Practice in Routine Radiotherapy Care: Identifying Differences Between Practitioners and Non-Practitioners in Sociodemographic, Clinical, Functional, and Quality-of-Life-Related Characteristics
Authors: Stake-Nilsson Kerstin , Gustafsson Silje , Tödt Kristina , Fransson Per , Efverman Anna
Published: October 2022

Objectives:

The objective of this study was to describe self-care practice during radiotherapy for cancer and to identify potential differences between practitioners and non-practitioners of self-care regarding sociodemographic, clinical, functional, and quality-of-life-related characteristics.

Methods:

In this descriptive study, 439 patients (87% response rate) undergoing radiotherapy responded to a study questionnaire regarding self-care, sociodemographic, clinical (eg, experienced symptoms), functional, and quality-of-life-related characteristics.

Results:

Of the 439 patients, 189 (43%) practiced at least one self-care strategy, while 250 (57%) did not. In total, the patients described 332 self-care practices, resulting in 14 different categories of self-care strategies. The 5 most common indicators of practicing self-care were fatigue, general wellbeing, psychological symptoms, nausea, vomiting and improving physical condition. The 5 most common self-care strategies were physical activity, increased recovery, healthy eating, distraction, and skincare. Patients who were married, were older than 69, patients with less education than university education, patients undergoing a combination of internal and external radiotherapy, patients experiencing fewer than 8 symptoms, and better quality of life, practiced self-care to a lower extent than did other patients. Functional capacity did not differ between self-care practitioners and non-practitioners.

Conclusion and Implications for Practice:

Of the patients undergoing radiotherapy, slightly less than half practiced self-care during an ordinary week of radiotherapy. Because older and less-educated patients were less likely to practice self-care, cancer care practitioners should consider paying particular attention to helping such patients with their self-care practice.
A Quasi-Experimental Study on the Effects of Community versus Custodial Sanctions in Youth Justice
Authors: Koops-Geuze Gwendolyn J. , Wermink Hilde T. , Weerman Frank M.
Published: October 2022

Although community sanctions have become a popular alternative to custodial sanctions in youth justice, primary questions about the recidivism effects of community sanctions remain unanswered. The current study aims to fill this gap through a quasi-experimental analysis of 2-year recidivism differences between 4,425 youth subject to community sanctions versus custodial sanctions in the Netherlands in 2015 and 2016. Recidivism was analyzed in terms of overall, serious, and very serious recidivism for the full sample, a low risk subsample, and a medium-high risk subsample. Findings indicate that youth subject to community sanctions are less likely to recidivate overall, and less like likely to recidivate seriously than youth subject to custodial sanctions. Community sanctions were found to be particularly beneficial for preventing very serious recidivism among low risk youth. Additionally, it was found that medium-high risk youth subject to community sanctions are less likely to recidivate overall, and less seriously than medium-high risk youth subject to custodial sanctions. Implications of these findings for future research and practice are discussed.
Extensor Carpi Ulnaris Tendinopathy in Athletes: A Review of the Conservative and Rehabilitative Options
Authors: Zarro Michael , Goel Ritu , Bickhart Nicole , May Catherine C. , Abzug Joshua M.
Published: October 2022

Background:

Extensor carpi ulnaris (ECU) tendinopathy is characterized by pain along the dorsal and ulnar aspect of the wrist and distal forearm. It is common in athletes who play stick and racquet sports due to repetitive motion and axial-loading through the wrist and forearm. Conservative therapeutic options include rest, the use of anti-inflammatory medications, and various injections. Rehabilitation via occupational or physical therapy includes therapeutic exercise, splinting, activity modification, manual therapy, and modalities.

Methods:

A narrative review of the literature on ECU tendinopathy is presented, and a case study approach is used to highlight the clinical management of this condition in an elite athlete.

Results:

An approach of medical management and rehabilitation allowed this patient to successfully return to play.

Conclusions:

A combination of conservative measures and rehabilitation can be used to treat ECU tendinopathy and permit patients to be symptom-free and return to their desired activities.
Hand Injuries During COVID-19 UK Lockdown: How Did the Pandemic Affect 1-Year Functional Outcomes?
Authors: Morcos Zeid , Barrett-Lee Joe , Hindi Fadi , Mahmoud Moustafa , Gavrila Cristina L. , Roberts Darren C.
Published: October 2022

Background:

The COVID-19 outbreak was declared a pandemic in March 2020, forcing the United Kingdom into a national lockdown. The aim was to evaluate the effect of this lockdown on hand injuries referred through the trauma and orthopedics virtual fracture clinic (VFC) service and their subsequent management given limited resources. This study also aimed to identify complications and evaluate functional outcomes.

Methods:

Patients referred through VFC at Queen Alexandra Hospital during April and May 2020 with hand injuries were analyzed. Isolated injuries to the carpus and wrist were excluded. Controls were compared over identical time spans prior to lockdown and after the restrictions were eased. Functional outcomes were measured using the Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) score, at 12 months after injury.

Results:

There was a 68% reduction in referrals of hand injuries during lockdown. Lower numbers of sporting injuries were seen, in contrast to an increased rate of falls, crush injuries, and recreational cycling. Despite a higher number of patients being discharged from VFC during lockdown, there were no increased rates of complications from conservatively managed hand fractures. Eighty percent reported low QuickDASH scores with a median of 2.3. Satisfaction was high, with 73% either satisfied or very satisfied with their treatment and outcome.

Conclusion:

This study demonstrates that there remains a burden of hand trauma during lockdowns, and therefore, service provision for future lockdowns should consider this. Most patients can be managed conservatively, and a high proportion can be discharged from VFC with low complication rates and high satisfaction.
Carbohydrate Intake and Its Association With Dietary Acid Load in U.S. Adults: Results From a Cross-Sectional Study
Authors: Storz Maximilian A. , Ronco Alvaro L.
Published: October 2022

Background: The safety profile of low-carbohydrate diets is controversial and poorly understood. We investigated the effects of low-moderate carbohydrate intake on dietary acid load (DAL), an emerging health risk factor and novel clinical marker associated with numerous adverse clinical outcomes. Methods: We used data from the National Health and Nutrition Examination Surveys to investigate how low-moderate carbohydrate intake quantitatively affects DAL (as assessed by PRAL and NEAP scores) and to contrast the results to DAL scores in individuals that meet carbohydrate intake recommendations. Results: We analyzed data from 23 825 individuals, of which 4891 consumed a low-moderate carbohydrate diet. Said individuals derived 37.84% of energy from carbohydrates, tended to be male, had a mean BMI of 28.47 kg/m2, and consumed significantly more energy from fat and protein ( P≤.01 for both) than individuals that met carbohydrate recommendations Low-moderate carbohydrate intake was associated with a significantly higher DAL. Mean PRALR, NEAPR, and NEAPF values were 26.12, 71.02, and 68.98 mEq/d, respectively. Multivariate regression revealed the highest DAL scores in individuals on a low-carbohydrate diet, obtaining <26% of energy from carbohydrates. Conclusions: Low-moderate carbohydrate intake is associated with increased DAL scores, which has been repeatedly associated with various health repercussions.
A novel cuproptosis-related lncRNA prognostic risk score model for gastric cancer based on bioinformatics
Authors: Du Xue , Xiao Yu , Chen Chunbao , Yang Lu , Cui Yu , Wu Tingting , Tan Bangxian
Published: October 2022

Objective

To establish an effective cuproptosis-related long non-coding ribonucleic acid (lncRNA) (CRL) prognostic risk score (RS) model (CRLPRSM) for the prediction of the outcomes of patients with gastric cancer (GC).

Introduction

Cuproptosis is an up-to-date mode of cell death, and its action mechanism is different from all other known mechanisms that regulate cell death. LncRNAs are RNA species that are over 200 nt long and do not encode proteins. They have prominent actions in tumor onset and development, and their involvement in a variety of intracellular regulatory processes is vital for cell proliferation and differentiation, so they may serve as prognostic biomarkers in tumor patients.

Methods

We retrieved cuproptosis-associated clinical and lncRNA expression data of GC cases from The Cancer Genome Atlas Stomach Adenocarcinoma (TCGA-STAD). Then a CRLPRSM was built based on univariate and multivariate Cox regression (UCR and MCR) analyses. As per the RS, the patients fell into high- and low-risk group. Later, the predictive efficacy of the CRLPRSM was confirmed with the aid of Kaplan-Meier (KM) analysis and receiver operating characteristic (ROC) curve analysis. Next, combining independent prognostic factors in clinical characteristics, we plotted a prognosis-related nomogram to predict one-year, three-year and five-year overall survival (OS) in GC patients. Finally, we implemented Gene Ontology enrichment analysis (GOEA) and Kyoto Encyclopedia of Genes and Genomes enrichment analysis (KEGGEA) for clarifying the possible biological actions and molecular mechanisms.

Results

The constructed CRLPRSM consisted of 3 CRLs, namely, AC092574.1, MAGI2-AS3, AC090204.1. It was found that the hazard ratio (HR) was 1.911 (1.337–2.731) ( p < 0.001) in UCR analysis and 1.852 (1.286–1.668) ( p < 0.001) in MCR analysis, and the AUC of the CRLPRSM was 0.649. Moreover, the KM analysis showed a pronounced intergroup difference in survival, and the nomogram illustrated some clinical benefits of CRLPRSM. Furthermore, GO terms and KEGG pathways were unveiled to be significantly enriched.

Conclusion

The constructed CRLPRSM has a significant predicted value for GC patient prognosis, and CRLs may become novel hallmarks for clinical treatment of GC.
Secondary characters in narratives of wrongful conviction
Authors: Umamaheswar Janani
Published: October 2022

Research on wrongful convictions has focused mainly on the relationships and interactions among wrongfully-convicted persons and state actors, perpetuating an overly-simplistic understanding of the harms of wrongful conviction. In this article, I analyze narratives of wrongful conviction obtained through in-depth interviews with 15 exonerated men in the U.S. to shift attention toward these stories’ “secondary characters”—those individuals who were neither the main protagonists nor the key antagonists in participants’ narratives, but who nonetheless significantly shaped how the men made sense of their experiences of harm and their journeys from victimhood to vindication. Drawing on research in narrative victimology, I argue that focusing on the secondary characters in wrongful conviction stories facilitates a more nuanced understanding of how the injustice of wrongful conviction is experienced and processed—one that avoids reproducing the binary logic of the criminal legal system, which too often reduces wrongful conviction cases to one-dimensional stories of innocent people versus the state.
Development and implementation of a longitudinal clinical database for down syndrome in a large pediatric specialty clinic: Methodology and feasibility
Authors: Baumer Nicole T. , Hojlo Margaret A. , Lombardo Angela M. , Milliken Anna L. , Pawlowski Katherine G. , Sargado Sabrina , Soccorso Cara , Davidson Emily J. , Barbaresi William J.
Published: October 2022

Down syndrome (DS) is a complex condition associated with multiple medical, developmental, and behavioral concerns. A prospective, longitudinal clinical database was integrated into a specialty Down Syndrome Program, with the goals of better understanding the incidence, course, and impact of co-occurring medical, neurodevelopmental, and mental health conditions in DS. We describe the process of developing the database, including a systematic approach to data collection and database infrastructure, and report on feasibility, challenges, and solutions of initial implementation. Between March 2018 and November 2021, data from 842 patients (ages 4.8 months to 26 years) was collected. Challenges included caregiver form completion as well as time and personnel required for successful implementation. With full integration into clinical visit flow, the database proved to be feasible. The database enables identification of patterns of development and health throughout the lifespan and it facilitates future data sharing and collaborative research to advance care.
Creating (in) the Arctic: Investigating collaboration and location through a case study of the Arctic noir serial Thin Ice
Authors: Grønlund Anders
Published: October 2022

The Swedish/Icelandic coproduced serial Tunn is [ Thin Ice] (2020) offers an insight into current possibilities and challenges of production in the Nordic Arctic region and the involvement of the developing Greenlandic screen industry. By analysing both off- and on-screen elements through a broad screen industry and location-driven approach, the explorative case study illustrates both a region and a screen industry in development as well as changing production practices. Furthermore, the article highlights the perceived value of location and cultural specificity in high-end TV drama from the multi-ethnic and multi-lingual Arctic region.
A Fresh Glimpse into Cartilage Immune Privilege
Authors: Garrity Carissa , Arzi Boaz , Haus Brian , Lee Cassandra A. , Vapniarsky Natalia
Published: October 2022

The increasing prevalence of degenerative cartilage disorders in young patients is a growing public concern worldwide. Cartilage’s poor innate regenerative capacity has inspired the exploration and development of cartilage replacement treatments such as tissue-engineered cartilages and osteochondral implants as potential solutions to cartilage loss. The clinical application of tissue-engineered implants is hindered by the lack of long-term follow-up demonstrating efficacy, biocompatibility, and bio-integration. The historically reported immunological privilege of cartilage tissue was based on histomorphological observations pointing out the lack of vascularity and the presence of a tight extracellular matrix. However, clinical studies in humans and animals do not unequivocally support the immune-privilege theory. More in-depth studies on cartilage immunology are needed to make clinical advances such as tissue engineering more applicable. This review analyzes the literature that supports and opposes the concept that cartilage is an immune-privileged tissue and provides insight into mechanisms conferring various degrees of immune privilege to other, more in-depth studied tissues such as testis, eyes, brain, and cancer.
Susceptibility-weighted imaging is helpful in diagnosis of cerebral gnathostomiasis
Authors: Hirunpat Pornrujee , Panyaping Theeraphol , Taebunpakul Piyakarn , Charoensri Attawit , Hirunpat Siriporn
Published: October 2022

Purpose

To describe the role of SWI compared with other MR imaging sequences and CT in diagnosis of cerebral gnathostomiasis.

Materials and methods

CTs and MRIs of patients with cerebral gnathostomiasis were retrospectively reviewed. The types of intracranial hemorrhage, including intraparenchymal hemorrhage (IPH), subdural hemorrhage (SDH), subarachnoid hemorrhage (SAH), and their locations were recorded.

Results

Four patients proven as cerebral gnathostomiasis were included. Intracranial hemorrhage was detected in all patients. There was IPH in all patients, SAH in 2 patients, and SDH in 2 patients. All patients (4/4) revealed hemorrhagic tracts which were very conspicuously seen on SWI. Other imaging sequences could also reveal hemorrhagic tracts in 3 patients (3/4) but are less conspicuously seen than SWI. None of the CT brains could detect hemorrhagic tracts.

Conclusions

Intracranial hemorrhage associated with hemorrhagic tract, best demonstrated by SWI, is the key imaging characteristic in diagnosis of cerebral gnathostomiasis.
Anxiety, fear extinction, and threat-related amygdala reactivity in children exposed to urban trauma
Authors: France John M. , Reda Mariam , Marusak Hilary A. , Riser Manessa , Wiltshire Charis N. , Davie William M. , Grasser Lana Ruvolo , Wanna Cassandra P. , Stenson Anaïs F. , Ely Timothy D. , Norrholm Seth D. , Stevens Jennifer S. , Jovanovic Tanja
Published: October 2022

Introduction

Childhood trauma is strongly associated with fear-related psychopathology, like anxiety and posttraumatic stress disorder (PTSD). Atypical fear extinction and neural responses to social threat (i.e., negative emotional faces) may serve as intermediate phenotypes preceding the emergence of fear-related psychopathology during childhood and adolescence. However, few studies have examined associations among these phenotypes in trauma-exposed youth.

Methods

29 9-year-old children with high rates of trauma exposure (Mdn = 4, min = 0, max= 14 total events) completed a fear-potentiated startle paradigm assessing fear conditioning and extinction and an emotional faces functional magnetic resonance imaging (fMRI) task assessing neural responses to fearful and neutral faces.

Results

Overall amygdala response was positively associated with anxiety (peak coordinates: x = −30, y = −6, z = −24; Z = 3.54; pFWEcorrected = 0.011; k = 24 voxels) and fear-potentiated startle during early extinction (peak coordinates x = 28, y = −6, z = −18; Z = 3.50; pFWEcorrected = 0.012; k = 19 voxels). Across the session, amygdala reactivity to fearful faces increased (F(1, 29) = 4.427, p = .044) and was positively associated with fear-potentiated startle during early extinction (r = .56, p = .002).

Conclusions

We found a positive association between increasing amygdala response to threatening faces and fear load, that is, heightened fear-potentiated startle during early extinction, in trauma-exposed children. These fear-based intermediate phenotypes may share underlying amygdala circuits, such that hyperactivity may represent an early marker of anxiety risk in trauma-exposed youth.
A qualitative exploratory study on the effects of formalin on mortuary attendants
Authors: Akortiakumah John Kwasi , Dartey Anita Fafa , Kuug Anthony Kolsabilik , Lotse Comfort Worna , Gnagmache Gideon K , Raji Abdul Sakibu
Published: October 2022

Objectives:

To explore the effects of formalin on mortuary attendants in nine selected hospitals in Ghana.

Methods:

The study applies a qualitative exploratory descriptive design in the overall collection and analysis of data. Purposive sampling was used to reach the saturation of 19 participants. The data were collected through semi-structured interviews and manually analysed using content analysis.

Results:

Five themes developed from the analysed data, namely, effects of formalin on the eyes, effects of formalin on the respiratory system, effects of formalin on the skin, effects on appetite, and formalin as a cancer-causing agent.

Conclusion:

This study has unveiled the negative effects of formalin on morgue attendants, which is likely to cause long-time health problems. It is therefore recommended that all mortuaries in Ghana should be assisted with protective equipment, in-service training, and practice of universal safety to help reduce risks associated with chemical hazards, especially formalin. There should be regular surveillance in the mortuaries and workers be screened regularly.
A 5-year-old with new-onset diabetes presenting with ketoacidosis, acute pancreatitis, and renal failure
Authors: Alexander Seth M , Shenoy Vivek , Kihlstrom Margaret , Levenson Amy
Published: October 2022

A 5-year-old girl presented to the emergency room with altered mental status secondary to severe diabetic ketoacidosis due to new-onset GAD65 antibody positive, type 1 diabetes mellitus. On hospital day 0, she developed anuria, shock, and hypertriglyceridemia-associated acute pancreatitis. Following intravenous insulin therapy, the patient’s ketoacidosis improved. Her other complications persisted for several days and improved only with significant fluid resuscitation and supportive interventions, including intubation, thoracostomy, and vasopressors. This case underscores the importance of recognizing the early warning signs of diabetic ketoacidosis and reviews how to appropriately manage its associated life-threatening complications.
Synophtalmia on a newborn
Authors: Bihamba Bira Laetitia , Sikakulya Franck Katembo , Mumbere Mupenzi , Mathe Jeff
Published: October 2022

Synophtalmia or cyclopia is a rare presentation of alobar holoprosencephaly. Cases which have been reported are stillborn or dead in post-delivery period. We are presenting a 3000-g live full-term newborn girl delivered by caesarean section with a well-marked cyclopia, but who died 30 min post-delivery. The case did not present with other abnormalities. The literature showed that genetic disorders are associated with cyclopia. A prenatal anomaly scan can help in the early detection of the condition and timely termination of the pregnancy can be conducted.
New mycosis fungoides–like lymphomatoid reaction following COVID-19 vaccination: A case report
Authors: Li Heidi Oi-Yee , Lipson Jennifer
Published: October 2022

Numerous cutaneous side effects arising from COVID-19 vaccination have been reported. Mycosis fungoides (MF) is a rare indolent form of cutaneous t-cell lymphoma. While the pathogenesis of MF is not well understood, it is thought to involve immune dysregulation. There have been reports of COVID-19 vaccination induced flares and recurrences of cutaneous lymphomas and lymphomatoid reactions. We present the first reported case of COVID-19 vaccine induced MF-like lymphomatoid reaction.
Computed tomographic pulmonary angiography: Three cases of low-tube-voltage acquisition with a slow injection of contrast medium
Authors: Urikura Atsushi , Yoshida Tsukasa , Endo Masahiro , Asakura Koiku , Sato Rui , Saiga Atsushi , Moriguchi Michihisa , Nakashima Kazuaki , Aramaki Takeshi
Published: October 2022

Acute pulmonary thromboembolism occurring during cancer treatment has been increasing with the number of cancer patients and chemotherapy cases. Computed tomographic pulmonary angiography (CTPA) for evaluating the pulmonary artery is generally performed using rapid injection of contrast medium. However, intravenous catheters for contrast medium injection might cause extravasation due to rapid injection. This case series describes three patients who underwent contrast-enhanced computed tomography combined with low-tube-voltage imaging and slow injection. Low-tube-voltage slow-injection CTPA can be an effective technique for obtaining high contrast enhancement while accommodating fragile veins and low injection rates.
Clinical Outcomes of Total Hip Arthroplasty With the Anterolateral Modified Watson-Jones Approach for Displaced Femoral Neck Fractures
Authors: Takemoto Naoki , Nakamura Takuya , Kagawa Katsura , Maruhashi Yoshinobu , Sasagawa Takeshi , Funaki Kiyonobu , Aikawa Takao , Yamamoto Daiki
Published: October 2022

Objective

In recent years, many studies have reported good results with total hip arthroplasty (THA) for displaced femoral neck fractures (FNFs). However, no study has reported the clinical outcomes of the anterolateral modified Watson–Jones THA (MWJ-THA) for displaced FNFs. This study aimed to investigate the clinical results of THA for displaced FNFs at our hospital and to discuss the advantages of MWJ-THA over THA with other approaches for displaced FNFs.

Methods

Forty-three patients who underwent MWJ-THA for displaced FNFs were included in this study. Patient characteristics, preinjury walking ability, activities of daily living, implants used, walking ability (at 1, 3, and 6 months after surgery), cup placement angle, clinical hip score, surgical complications, revision surgery, and death within 1 year after surgery were investigated.

Results

The mean age of the 43 patients was 63.3 years, and the mean body mass index (kg/m2) was 21.1. Regarding the heads used, 28-mm heads were used in 4 patients, 32-mm heads were used in 32 patients, and 36-mm heads were used in 7 patients. The cups were placed in the Lewinnek safety zone (93.0%). Four patients had stem sinkage of a few millimeters. 6 months postoperatively, 38 patients walked unaided, and 4 patients walked with a cane. The Harris Hip Score averaged over 90 points at all time points. No postoperative dislocation was observed. Two patients died within 1 year postoperatively.

Conclusion

In this study, MWJ-THA was performed for displaced FNFs and resulted in no postoperative dislocations. Furthermore, more than 90% of the patients regained their preinjury walking ability at 6 months postoperatively. MWJ-THA has great dislocation control and is effective in treating displaced FNFs.
Façade Creation and Workplace Bullying: A Mediated Moderation Model
Authors: Liang Huai-Liang
Published: October 2022

This study examines the buffering role of a psychological contract breach in the process leading from façade creation (i.e., suppressing one’s own values and pretending to hold organization values) to workplace bullying through leader–member exchange (LMX). This study predicts that façade creation, particularly when the level of psychological contract breach is high, produces high LMX, which reduces bullying in the workplace. In total, 302 employee–employer dyads (265 males, 37 females; average age 46.07 years) from a large bank in Taiwan were surveyed. Surveys were conducted at two time points for employees and at one time point for their employers who volunteered. The findings of this study found significant relationships between facades of conformity and workplace bullying. This study further found that LMX mediates the relationship between façade creation and workplace bullying and demonstrate that a perceived breach of psychological contract moderates this mediating pathway. Strong psychological contract breach increases the relationship between façade creation and LMX. A time-lag design of two time periods and two different sources (i.e., employers and employees) were utilized to diminish common method variables (CMV) in this study. Implications and directions for future study are discussed.
Doing Business and Tax Evasion: Evidence from Asian Countries
Authors: Rashid Md. Harun Ur , Ahmad Afzal , Abdullah Muhammad Saleh , Ahmmed Monir , Islam Serajul
Published: October 2022

The study examines the relationship between doing business factors and tax evasion in Asian countries. To this end, Ordinary Least Square (OLS), along with a fixed and random effect model, was used to analyze the 5-year data (2011–2015) of 35 Asian countries obtained from the global competitiveness report and World Development Indicators. The findings indicated that a high level of corruption, a high tax rate, limited access to finance, strict tax regulation, government instability, and poor ethics promote tax evasion. Extending the socio-economic theory, the findings of the study provide the tax administration and governments of Asian countries with insights into the mechanism by which certain business factors influence tax evasion. Moreover, the study offers some valuable guidelines for formulating suitable economic policies that engender a reduction in tax evasion.
Elevated Anxious and Depressed Mood Relates to Future Executive Dysfunction in Older Adults: A Longitudinal Network Analysis of Psychopathology and Cognitive Functioning
Authors: Zainal Nur Hani , Newman Michelle G.
Published: October 2022

Vulnerability models posit that executive-functioning (EF) problems centrally affect future common (vs. rare) psychopathology symptoms. Conversely, scar theory postulates that depression/anxiety (vs. other psychopathology) symptoms centrally influence reduced EF. However, most studies so far have been cross-sectional. We used cross-lagged panel network analysis to determine temporal and component-to-component relations on this topic. Community older adults participated across four time points. Cognitive tests and the caregiver-rated Neuropsychiatric Inventory assessed nine psychopathology and eight cognitive-functioning nodes. Nodes with the highest bridge expected influence cross-sectionally were agitation and episodic memory. Episodic memory had the strongest inverse relation with age. Agitation had the strongest negative association with global cognition. EF nodes tended to be centrally affected by prior depressed and anxious moods rather than influential on any future nodes. Heightened anxious and depressed mood (vs. other nodes) centrally predicted future decreased EF-related (vs. non-EF-related) nodes in older adults, supporting scar (vs. vulnerability) theory.
Long-Term Clinical Course of Patients After Decompression and Posterior Instrumented Fusion Surgery for Thoracic Ossification of the Posterior Longitudinal Ligament: An Average Follow-Up of 18 years
Authors: Takahata Masahiko , Endo Tsutomu , Koike Yoshinao , Abumi Kuniyoshi , Suda Kota , Fujita Ryo , Murakami Toshifumi , Sudo Hideki , Yamada Katsuhisa , Ohnishi Takashi , Ura Katsuro , Ukeba Daisuke , Iwasaki Norimasa
Published: October 2022

Study Design

Retrospective observational study.

Objectives

To evaluate the long-term recurrence rates and functional status of patients with thoracic ossification of the posterior longitudinal ligament (OPLL) after decompression and posterior fusion surgery.

Methods

Thirty-seven consecutive patients who underwent posterior thoracic spine surgery at a single institution were retrospectively reviewed. The long-term neurological and functional outcomes of 25 patients who were followed up for ≥10 years after surgery were assessed. Factors associated with the recurrence of myelopathy were also analyzed.

Results

The mean preoperative Japanese Orthopaedic Association score was 3.7, which improved to 6.5 at postoperative year 2 and declined to 6.0 at a mean follow-up of 18 years. No patient experienced a relapse of myelopathy due to OPLL within the instrumented spinal segments. However, 15 (60%) patients experienced late neurological deterioration, 10 of whom had a relapse of myelopathy due to OPLL or ossification of the ligamentum flavum (OLF) in the region outside the primary operative lesion, while 4 developed myelopathy due to traumatic vertebral fracture of the ankylosed spine. Young age, a high body mass index, and lumbar OPLL are likely associated with late neurological deterioration.

Conclusions

Decompression and posterior instrumented fusion surgery is a reliable surgical procedure with stable long-term clinical outcomes for thoracic OPLL. However, as OPLL may progress through the spine, attention should be paid to the recurrence of paralysis due to OPLL or OLF in regions other than the primary operative lesion and vertebral fractures of the ankylosed spine after surgery for thoracic OPLL.
Biopsy Confirmed Doxycycline Induced Gastric Mucosal Injury
Authors: Gaulden Hannah , Dungan William , Romano John , Willner Ira
Published: October 2022

Doxycycline (DOX) is a tetracycline antibiotic that is prescribed for treating a variety of infections involving the skin, respiratory tract, and urogenital system. Adversely, esophageal mucosal injury due to DOX is well described; however, gastric mucosal injury is less commonly reported and may result in severe gastrointestinal hemorrhage and occasionally, perforation. In most reported cases of DOX-induced gastric lesions, patients are symptomatic upon presentation leading to endoscopic evaluation and diagnosis with biopsy. However, severe gastric insults may go unrecognized in rare cases of asymptomatic patients, increasing the risk of mortality.
“It Was Hard, and It Still Is . . .”: Women of Color Navigating HSI STEM Transfer Pathways
Authors: Herrera Felisha A. , Rodriguez-Operana Victoria C. , Kovats Sánchez Gabriela , Cerrillos Aileen , Marquez Briana
Published: October 2022

Women of color (WOC) continue to be underrepresented in the fields of science, technology, engineering, and mathematics (STEM), where they often experience racism and sexism within disciplinary contexts that have historically privileged men and Whiteness. Participant narratives gained through focus-group and follow-up interviews illuminate the racialized and gendered STEM transfer experiences of 21 WOC who attended 2- and 4-year Hispanic-Serving Institutions (HSIs). Using a multidimensional intersectional approach, we explore the interplay between the complex identity experiences of WOC and the dynamic intersections of their transfer pathways across 2- and 4-year HSIs and within STEM disciplinary contexts. Findings underscore the inequities that continue to pervade STEM and highlight opportunities for transforming disciplinary and institutional cultures, particularly within HSI STEM transfer pathways, where there is great potential for these diverse institutions to support, validate, and benefit from the unique contributions of WOC.
Use of daratumumab in a patient with proliferative glomerulonephritis with monoclonal immunoglobulin deposition: A case report
Authors: Doddi Akshith , Ibrahim Dalia , Shawwa Khaled
Published: October 2022

Monoclonal gammopathy of renal significance (MGRS) is a pathogenic entity associated with significant morbidity, mainly end stage kidney disease. Proliferative glomerulonephritis with monoclonal immunoglobulin deposition (PGNMID), a type of MGRS, is a specific disease resulting from the deposition of a monoclonal immunoglobulin leading to kidney damage. While PGNMID has been recognized to lead to end-stage kidney disease, until recently there was no evidence to guide treatment. Here, we report a case of a patient with PGNMID who responded well to daratumumab.
Urban form and COVID-19 cases and deaths in Greater London: An urban morphometric approach
Authors: Venerandi Alessandro , Aiello Luca Maria , Porta Sergio
Published: October 2022

The COVID-19 pandemic generated a considerable debate in relation to urban density. This is an old debate, originated in mid 19th century’s England with the emergence of public health and urban planning disciplines. While popularly linked, evidence suggests that such relationship cannot be generally assumed. Furthermore, urban density has been investigated in a spatially coarse manner (predominantly at city level) and never contextualised with other descriptors of urban form. In this work, we explore COVID-19 and urban form in Greater London, relating a comprehensive set of morphometric descriptors (including built-up density) to COVID-19 deaths and cases, while controlling for socioeconomic, ethnicity, age and co-morbidity. We describe urban form at individual building level and then aggregate information for official neighbourhoods, allowing for a detailed intra-urban representation. Results show that: (i) control variables significantly explain more variance of both COVID-19 cases and deaths than the morphometric descriptors; (ii) of what the latter can explain, built-up density is indeed the most associated, though inversely. The typical London neighbourhood with high levels of COVID-19 infections and deaths resembles a suburb, featuring a low-density urban fabric dotted by larger free-standing buildings and framed by a poorly inter-connected street network.
Summary Report of the Arthritis Foundation and the American Orthopaedic Foot & Ankle Society’s Symposium on Targets for Osteoarthritis Research: Part 1: Epidemiology, Pathophysiology, and Current Imaging Approaches
Authors: Kim Jason S. , Amendola Annunziato , Barg Alexej , Baumhauer Judith , Brodsky James W. , Cushman Daniel M. , Gonzalez Tyler A. , Janisse Dennis , Jurynec Michael J. , Lawrence Marsh J. , Sofka Carolyn M. , Clanton Thomas O. , Anderson Donald D.
Published: October 2022

This first of a 2-part series of articles recounts the key points presented in a collaborative symposium sponsored jointly by the Arthritis Foundation and the American Orthopaedic Foot & Ankle Society with the intent to survey the state of scientific knowledge related to incidence, diagnosis, pathologic mechanisms, and injection treatment options for osteoarthritis (OA) of the foot and ankle. A meeting was held virtually on December 3, 2021. A group of experts were invited to present brief synopses of the current state of knowledge and research in this area. Part 1 overviews areas of epidemiology and pathophysiology, current approaches in imaging, diagnostic and therapeutic injections, and genetics. Opportunities for future research are discussed. The OA scientific community, including funding agencies, academia, industry, and regulatory agencies, must recognize the needs of patients that suffer from arthritis of foot and ankle. The foot and ankle contain a myriad of interrelated joints and tissues that together provide a critical functionality. When this functionality is compromised by OA, significant disability results, yet the foot and ankle are generally understudied by the research community.

Level of Evidence: Level V - Review Article/Expert Opinion.
Therapeutic Potential of miRNAs for Type 2 Diabetes Mellitus: An Overview
Authors: Palihaderu PADS , Mendis BILM , Premarathne JMKJK , Dias WKRR , Yeap Swee Keong , Ho Wan Yong , Dissanayake AS , Rajapakse IH , Karunanayake P , Senarath U , Satharasinghe DA
Published: October 2022

MicroRNA(miRNA)s have been identified as an emerging class for therapeutic interventions mainly due to their extracellularly stable presence in humans and animals and their potential for horizontal transmission and action. However, treating Type 2 diabetes mellitus using this technology has yet been in a nascent state. MiRNAs play a significant role in the pathogenesis of Type 2 diabetes mellitus establishing the potential for utilizing miRNA-based therapeutic interventions to treat the disease. Recently, the administration of miRNA mimics or antimiRs in-vivo has resulted in positive modulation of glucose and lipid metabolism. Further, several cell culture-based interventions have suggested beta cell regeneration potential in miRNAs. Nevertheless, few such miRNA-based therapeutic approaches have reached the clinical phase. Therefore, future research contributions would identify the possibility of miRNA therapeutics for tackling T2DM. This article briefly reported recent developments on miRNA-based therapeutics for treating Type 2 Diabetes mellitus, associated implications, gaps, and recommendations for future studies.
Lateral Canthotomy and Cantholysis for Spontaneous Retrobulbar Hemorrhage With Normal Intraocular Pressures: Case Report and Review of the Literature
Authors: Lem Melinda , Oyur Kadir Berat , Labove Gabrielle , Hoang-Tran Cindy , Bhola Rahul , Pfaff Miles J.
Published: October 2022

Spontaneous retrobulbar hemorrhage (RBH) is uncommon and typically occurs secondary to vascular malformations, coagulopathies, hypertension, or strenuous activities in the setting of elevated intraocular pressure (IOP). RBH can cause orbital compartment syndrome (OCS) with resultant permanent vision loss. We present a case of spontaneous RBH in an 18-year-old male with a history of acute lymphoblastic leukemia (ALL) and sepsis. While IOPs were normal, the patient exhibited symptoms of OCS in which a lateral canthotomy and cantholysis were performed. This case highlights the importance of the clinical exam when treating a patient with suspected OCS and demonstrates that intraocular pressures need not be elevated for both diagnosis and intervention.
Identifying criteria for effective urban vehicle access regulations adoption
Authors: Ogunkunbi Gabriel Ayobami , Meszaros Ferenc
Published: October 2022

Background

Urban Vehicle Access Regulations (UVAR) hold great potential to reduce negative transport externalities driven by increased mobility demand and rapid urbanisation. However, as they are potential measures to the wicked problem of climate change mitigation and achieving overall sustainability, their implementation pathways are often complex due to the multidimensionality of sustainability and other challenges. Although decision support tools like the multi-criteria decision analysis might help simplify these complexities, selecting the appropriate criteria based on the peculiarity of UVAR remains pertinent. This study contributes to the sustainable transport decision support literature to address this challenge by identifying relevant criteria for the UVAR measure planning process using the Delphi survey approach.

Results

It begins with 23 criteria systematically selected from scientific literature and clustered into four dimensions in the first round. This was expanded into 30 criteria and five dimensions in the second survey round based on the participating experts' ratings and rankings. The consensus results showed that most of the identified criteria were considered to be of great potential in UVAR measure planning, with public acceptability, stakeholder engagement, political agenda, and the potential impacts on air pollution and accessibility considered the most important.

Conclusions

Apart from helping urban authorities select feasible and effective UVAR measures, the resulting assessment structure will also help identify the main barriers and drivers for UVAR adoption. The assessment structure will also aid the monitoring and evaluation phases of the measures upon implementation.