bluuebunny/crossref_metadata_2025 huggingface dataset:
SARS-CoV-2 mRNA Vaccine Breakthrough Infections in Fully Vaccinated Healthcare Personnel: A Systematic Review
Authors: Ledda Caterina , Costantino Claudio , Motta Giuseppe , Cunsolo Rosario , Stracquadanio Patrizia , Liberti Giuseppe , Maltezou Helena C. , Rapisarda Venerando
Published: January 2022

The number of people vaccinated against COVID-19 increases worldwide every day; however, it is important to study the risk of breakthrough infections in vaccinated individuals at high risk of exposure such as healthcare personnel (HCP). A systematic literature review (SLR) applying the PRISMA declaration and the PECOS format using the following entry terms was used: “Health Personnel OR Healthcare Worker OR Healthcare Provider OR Healthcare Personnel AND breakthrough OR infection after vaccine*”. The research was carried out utilizing the following databases: SCOPUS, PubMed, Embase, and Web of Sciences. An overall very low incidence of post-vaccination breakthrough infections was found, ranging from 0.011 to 0.001 (per 100 individuals at risk). Our findings further support the published high effectiveness rates of mRNA vaccines in preventing SARS-CoV-2 infections among fully vaccinated HCP. Additional studies are needed to define the duration of the vaccine-induced protection among HCP.
Dengue Fever in Italy: The “Eternal Return” of an Emerging Arboviral Disease
Authors: Riccò Matteo , Peruzzi Simona , Balzarini Federica , Zaniboni Alessandro , Ranzieri Silvia
Published: January 2022

Enhanced surveillance for dengue virus (DENV) infections in Italy has been implemented since 2012, with annual reports from the National Health Institute. In this study, we summarize available evidence on the epidemiology of officially notified DENV infections from 2010–2021. In total, 1043 DENV infection cases were diagnosed, and most of them occurred in travelers, with only 11 autochthonous cases. The annual incidence rates of DENV infections peaked during 2019 with 0.277 cases per 100,000 (95% confidence interval [95% CI] 0.187–0.267), (age-adjusted incidence rate: 0.328, 95% CI 0.314–0.314). Cases of DENV were clustered during the summer months of July (11.4%), August (19.3%), and September (12.7%). The areas characterized by higher notification rates were north-western (29.0%), and mostly north-eastern Italy (41.3%). The risk for DENV infection in travelers increased in the time period 2015–2019 (risk ratio [RR] 1.808, 95% CI 1.594–2.051) and even during 2020–2021 (RR 1.771, 95% CI 1.238–2.543). Higher risk for DENV was additionally reported in male subjects compared with females subjects, and aged 25 to 44 years, and in individuals from northern and central Italy compared to southern regions and islands. In a multivariable Poisson regression model, the increased number of travelers per 100 inhabitants (incidence rate ratio [IRR] 1.065, 95% CI 1.036–1.096), the incidence in other countries (IRR 1.323, 95% CI 1.165–1.481), the share of individuals aged 25 to 44 years (IRR 1.622, 95% CI 1.338–1.968), and foreign-born residents (IRR 2.717, 95% CI 1.555–3.881), were identified as effectors of annual incidence. In summary, although the circulation of DENV remains clustered among travelers, enhanced surveillance is vital for the early detection of human cases and the prompt implementation of response measures.
Diagnosis and Localization of Prostate Cancer via Automated Multiparametric MRI Equipped with Artificial Intelligence
Authors: Oishi Yuichiro , Kitta Takeya , Osawa Takahiro , Abe Takashige , Shinohara Nobuo , Nosato Hirokazu , Sakanashi Hidenori , Murakawa Masahiro
Published: January 2022

Prostate MRI scans for pre-biopsied patients are important. However, fewer radiologists are available for MRI diagnoses, which requires multi-sequential interpretations of multi-slice images. To reduce such a burden, artificial intelligence (AI)-based, computer-aided diagnosis is expected to be a critical technology. We present an AI-based method for pinpointing prostate cancer location and determining tumor morphology using multiparametric MRI. The study enrolled 15 patients who underwent radical prostatectomy between April 2008 and August 2017 at our institution. We labeled the cancer area on the peripheral zone on MR images, comparing MRI with histopathological mapping of radical prostatectomy specimens. Likelihood maps were drawn, and tumors were divided into morphologically distinct regions using the superpixel method. Likelihood maps consisted of pixels, which utilize the cancer likelihood value computed from the T2-weighted, apparent diffusion coefficient, and diffusion-weighted MRI-based texture features. Cancer location was determined based on the likelihood maps. We evaluated the diagnostic performance by the area under the receiver operating characteristic (ROC) curve according to the Chi-square test. The area under the ROC curve was 0.985. Sensitivity and specificity for our approach were 0.875 and 0.961 (p < 0.01), respectively. Our AI-based procedures were successfully applied to automated prostate cancer localization and shape estimation using multiparametric MRI.
Human T-Cell Leukemia Virus Type 1 Envelope Protein: Post-Entry Roles in Viral Pathogenesis
Authors: Maksimova Victoria , Panfil Amanda R.
Published: January 2022

Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus that is the causative infectious agent of adult T-cell leukemia/lymphoma (ATL), an aggressive and fatal CD4+ T-cell malignancy, and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a chronic neurological disease. Disease progression in infected individuals is the result of HTLV-1-driven clonal expansion of CD4+ T-cells and is generally associated with the activities of the viral oncoproteins Tax and Hbz. A closely related virus, HTLV-2, exhibits similar genomic features and the capacity to transform T-cells, but is non-pathogenic. In vitro, HTLV-1 primarily immortalizes or transforms CD4+ T-cells, while HTLV-2 displays a transformation tropism for CD8+ T-cells. This distinct tropism is recapitulated in infected people. Through comparative studies, the genetic determinant for this divergent tropism of HTLV-1/2 has been mapped to the viral envelope (Env). In this review, we explore the emerging roles for Env beyond initial viral entry and examine current perspectives on its contributions to HTLV-1-mediated disease development.
Ebola Virus GP Activates Endothelial Cells via Host Cytoskeletal Signaling Factors
Authors: Moni Benedicte Mpia , Sakurai Yasuteru , Yasuda Jiro
Published: January 2022

Ebola virus disease (EVD) is a lethal disease caused by the highly pathogenic Ebola virus (EBOV), and its major symptoms in severe cases include vascular leakage and hemorrhage. These symptoms are caused by abnormal activation and disruption of endothelial cells (ECs) whose mediators include EBOV glycoprotein (GP) without the need for viral replication. However, the detailed molecular mechanisms underlying virus–host interactions remain largely unknown. Here, we show that EBOV-like particles (VLPs) formed by GP, VP40, and NP activate ECs in a GP-dependent manner, as demonstrated by the upregulation of intercellular adhesion molecules-1 (ICAM-1) expression. VLPs-mediated ECs activation showed a different kinetic pattern from that of TNF-α-mediated activation and was associated with apoptotic ECs disruption. In contrast to TNF-α, VLPs induced ICAM-1 overexpression at late time points. Furthermore, screening of host cytoskeletal signaling inhibitors revealed that focal adhesion kinase inhibitors were found to be potent inhibitors of ICAM-1 expression mediated by both TNF-α and VLPs. Our results suggest that EBOV GP stimulates ECs to induce endothelial activation and dysfunction with the involvement of host cytoskeletal signaling factors, which represent potential therapeutic targets for EVD.
Prediction Error Stabilization and Long-Term Standard Results with a Monofocal Intraocular Lens
Authors: Macías-Murelaga Beatríz , Garay-Aramburu Gonzaga , Bergado-Mijangos Roberto , Coello-Ojeda Daniel , Ozaeta Itziar , Garcia-Gómez Pio Jésus , Garrido-Fierro Jesús , Rodríguez-Vallejo Manuel , Fernández Joaquín
Published: January 2022

The aim of this study was to assess the stability and differences between objective (O-Rx) and subjective (S-Rx) refraction for the assessment of the prediction error (PE). A secondary aim was to report the results of a monofocal intraocular lens (IOL). 100 subjects were included for whom S-Rx and O-Rx were obtained for all visits, and for visual performance, posterior capsular opacification incidence and Nd:YAG rates at 12 months. Either S-Rx and O-Rx showed a hyperopic shift from 1 to 6 months (p < 0.05) and stabilization after 6 months. S-Rx was related with the axial length (rho = −0.29, p = 0.007), obtaining a major tendency towards hyperopia in short eyes implanted with high-power IOLs. O-Rx showed a myopic shift in comparison to S-Rx (p < 0.05). This resulted in a decrease of the number of eyes in ±0.50 D and ±1.00 D from 79 to 67% and from 94 to 90%, respectively. The median (interquartile range) uncorrected and corrected visual acuities were 0.1 (0.29) and 0 (0.12) logMAR, respectively, and seven eyes required Nd:YAG capsulotomy at 12 months. Some caution should be taken in PE studies in which O-Rx is used or S-Rx is measured in a 1-month follow-up. Constant optimization should be conducted for this IOL after S-Rx stabilization.
Clinical prediction rules for childhood urinary tract infections: a cross-sectional study in ambulatory care
Authors: Boon Hanne Ann , Verbakel Jan Y , De Burghgraeve Tine , Bruel Ann Van den
Published: January 2022

Background

Diagnosing childhood urinary tract infections (UTIs) is challenging. Clinical prediction rules may help to identify children that require urine sampling. However, there is a lack of research to determine the accuracy of the scores in general practice.

Aim

To validate clinical prediction rules (UTI Calculator [UTICalc], A Diagnosis of Urinary Tract Infection in Young Children [DUTY], and Gorelick score) for paediatric UTIs in primary care.

Design & setting

Post-hoc analysis of a cross-sectional study in 39 general practices and two emergency departments (EDs). The study took place in Belgium from March 2019–March 2020.

Method

Physicians recruited acutely ill children aged ≤18 years and sampled urine systematically for culture. Per rule, an apparent validation was performed, and sensitivities and specificities were calculated with 95% confidence intervals (CIs) per threshold in the target group. For the DUTY coefficient-based algorithm, a logistic calibration was performed and the area under the receiver operating characteristic curve (AUC) was calculated with 95% CI.

Results

Of 834 children aged ≤18 years recruited, there were 297 children aged <5 years. The UTICalc and Gorelick score had high-to-moderate sensitivity and low specificity: UTICalc (≥2%) 75% and 16%, respectively; Gorelick (≥2 variables) 91% and 8%, respectively. In contrast, the DUTY score ≥5 points had low sensitivity (8%) but high specificity (99%). Urine samples would be obtained in 72% versus 38% (UTICalc), 92% versus 38% (Gorelick) or 1% versus 32% (DUTY) of children, compared with routine care. The number of missed infections per score was 1/4 (UTICalc), 2/23 (Gorelick), and 24/26 (DUTY). The UTICalc + dipstick model had high sensitivity and specificity (100% and 91%), resulting in no missed cases and 59% (95% CI = 49% to 68%) of antibiotics prescribed inappropriately.

Conclusion

In this study, the UTICalc and Gorelick score were useful for ruling out UTI, but resulted in high urine sampling rates. The DUTY score had low sensitivity, meaning that 92% of UTIs would be missed.
Creating and Managing EU Funded Research Networks: An Exploratory Case
Authors: Dooly Zeta , Duane Aidan , O’Driscoll Aidan
Published: January 2022

The collaborative European funded research and development landscape drives competitiveness among innovative organisations. Recently it has seen the rise of public private partnerships significantly impacting the dynamics of these networks.  Thus, the complexity of managing research networks has intensified with the increased diversity of research network members. Additionally, the emergence of the academic entrepreneur has augmented the focus of educational institutions to include innovation and building start-up organisations.  The impact of research is scalable if an optimum research network is created and managed effectively. This paper investigates network embeddedness; the nature of relationships, links and nodes within a research network, specifically their structure, configuration and quality. The contribution of this paper extends our understanding for establishing and maintaining effective collaborative research networks.  The effects of network embeddedness are recognized in the literature as pertinent to innovation and the economy. Network theory literature claims that networks are essential to innovative clusters such as Silicon valley and innovation in high tech industries. The concept of embeddedness is what differentiates network theory from economic theory. This study adopts a qualitative approach and uncovers some of the challenges of multi-disciplinary research through case study insights. One challenge is competition between network members over ownership and sharing of data. The contribution of this paper recommends the establishment of scaffolding to accommodate cooperation in research networks, role appointment, and addressing contextual complexities early to avoid problem cultivation. Furthermore, it suggests recommendations in relation to network formation, incubation and operations. The network capability is enhanced by the recognition of network theory, open innovation and social exchange with the understanding that the network structure has an impact on innovation and social exchange in research networks and subsequently on research output. The research concludes that the success of collaborative research is reliant upon establishing a common language and understanding between network members to realise their research objectives.
The Effect Of Good Corporate Governance, Work Life Balance, Talent Management And Person Organization Fit On Employee Performance At The Planning, Research And Development Agency Of Bukittinggi City
Authors: Dharma Robby , Gusnawati Lestari
Published: January 2022

The purpose of this research journal is to find out how much "The Influence of Good Corporate Governance, Work Life Balance, Talent Management and Person Organization Fit on Employee Performance at the Planning, Research and Development Agency (Bapelitbang) of Bukittinggi City. Methods of collecting data through surveys, interviews, and questionnaires with a sample of 34 respondents.The analytical method used is Multiple Linear Regression Analysis.The results of data analysis concluded, partially there is a positive and significant effect of Good Corporate Governance on Employee Performance. Partially there is a positive and significant effect of work life balance on employee performance. Partially there is a positive and significant influence of Talent Management on Employee Performance. Partially there is a positive and significant effect of Personorganization Fit on Employee Performance. Simultaneously there is a positive and significant influence of Good Corporate Governance, Work Life balance, Talent Management, Personorganization Fit on Employee Performance. The contribution of Good Corporate Governance, Work Life balance, Talent Management, Personorganization Fit variables is 0.641 or 64.1% while the remaining 35.9% is influenced by other variables
Faktor-Faktor yang Mempengaruhi Akses Kesehatan
Authors: Maulany Raditiya Firda , Dianingati Ragil Setia , Annisaa' Eva
Published: January 2022

Akses kesehatan merupakan bentuk dari pelayanan kesehatan yang dapat dijangkau oleh masyarakat. Akses kesehatan seringkali hanya dilihat dari sudut pandang penyedia layanan, sementara akses dari sisi masyarakat sebagai pengguna kurang terperhatikan. Penelitian tentang akses pelayanan kesehatan dari perspektif pengguna dirasakan masih sangat kurang. Penelitian tentang akses pelayanan kesehatan dari sisi pengguna masih kurang. Peningkatan kualitas pelayanan kesehatan dari segi akses memerlukan perspektif yang komprehensif dari dua sisi yang berbeda. Tujuan dari review artikel ini adalah untuk menganalisis faktor-faktor yang mempengaruhi masyarakat dalam mengakses fasilitas kesehatan. Desain metode yang digunakan merupakan review artikel, hasil data yang diperoleh berdasarkan kumpulan dari penelitian terkait. Metode pecarian sumber dilakukan dengan menggunakan kata kunci “akses kesehatan”, “pelayanan kesehatan” dan “fasilitas kesehatan” yang dilakukan pada bulan Desember 2020.  Kriteria inklusi artikel yang digunakan yaitu artikel tahun 2011-2020 dan bertujuan mengetahui faktor-faktor yang mempengaruhi akses fasilitas kesehatan. Kriteria eksklusi penelitian ini yaitu review artikel, artikel yang tidak menyediakan full text atau hanya menyediakan abstrak dan hasil skripsi, tesis, disertasi. Pencarian dari database menghasilkan 73 artikel, dimana hanya terdapat 5 artikel yang memenuhi kriteria inklusi. Hasil review artikel menunjukkan bahwa faktor-faktor yang mempengaruhi akses kesehatan antara lain jenis kelamin, waktu tempuh, lokasi tempat tinggal, biaya transportasi, persepsi masyarakat tentang kesehatan, pendapatan, pendidikan, pengetahuan.
Formulasi Sediaan Salep Ekstrak Daun Puring (Codiaeum variegatum L.) Dengan Basis Hidrokarbon Dan Larut Air
Authors: Sawiji Repining Tiyas , Sukmadiani Ni Wayan Ari
Published: January 2022

Daun puring (Codiaeum variegatum L.) merupakan tanaman hias yang banyak digunakan sebagai bahan obat tradisional. Daun puring mengandung senyawa metabolit sekunder diantaranya terpenoida, flavonoida, saponin, alkaloida, dan tannin. Senyawa metabolit flavonoida diketahui memiliki aktivitas antibakteri. Tujuan dari penelitian adalah untuk memformulasikan sediaan salep ekstrak daun puring dan mengetahui pengaruh basis formula terhadap stabilitas fisiknya. Penelitian ini merupakan penelitian eksperimental laboratorium yang dilakukan dengan pengujian stabilitas fisik metode freeze thaw dan sifat fisik salep yang meliputi uji organoleptis, homogenitas, pH, daya lekat, daya sebar, dan viskositas. Data dianalisis secara statistika dengan metode uji ANOVA dan Kruskal walis. Hasil penelitian menunjukkan bahwa ekstrak daun puring dapat diformulasikan menjadi sediaan salep dengan basis hidrokarbon dan basis larut air. Formulasi ekstrak daun puring terhadap basis hidrokarbon dan larut air berpengaruh terhadap stabilitas fisik seperti uji organoleptis, pH, homogenitas, dan daya sebar namun tidak stabil pada uji viskositas dan daya lekat.
Pengaruh Trietanolamin Dan Asam Stearat Terhadap Mutu Fisik Dan Stabilitas Mekanik Krim Sari Buah Tomat
Authors: Mudhana Aditya Rahma , Pujiastuti Anasthasia
Published: January 2022

Tomatoes contain lycopene which is an antioxidant. Antioxidant preparations can be made in the form of a cream with components of an oil phase, a water phase and an emulsifier. Emulsifiers that can be used are triethanolamine (TEA) and stearic acid. This study aims to determine the effect of triethanolamine and stearic acid as emulsifiers on the physical quality and mechanical stability of tomatoes extract cream. The use of triethanolamine and stearic acid with a ratio of 2%:5%; 3%:10%; 4%:15%. The test are the physical characteristics of tomatoes extract cream included organoleptic, homogeneity, cream type, pH, viscosity, spreadability, adhesion, protection and mechanical stability using the centrifugation method. The results of the phytochemical screening of tomatoes extract were positive for triterpenoids. The test results of the three cream formulas are odorless, semi-solid form, light orange to white color, homogeneous, cream type M/A, pH 5.25 - 6.26; viscosity 5,376 cP - 14,370 cP, spreadability 4 - 5,067 cm, adhesion 4 - 11.6 seconds, protection power 2 - 5.2 seconds. The three cream formulas did not undergo phase separation. The higher concentration of TEA and stearic acid had an effect on viscosity, pH value, adhesion, dispersibility and protection, but had no effect on organoleptic, homogeneity, cream type, and stability. tomatoes extract cream with a concentration of TEA:stearic acid 2%:5% gave the best physical quality.
Guidance of Self-protection efforts during the covid-19 pandemic, through community empowerment activities in Kasugengan Kidul Village, Depok Cirebon
Authors: Indawati Iin , Kunaedi Aan , Selawati Anis , Angela Elva
Published: January 2022

The impact of the Covid-19 pandemic in Indonesia continues increasing significantly, even positive cases reached up to 235,173,857 people. The existence of Student Work Study (KKM) activities is expected to make a positive contribution during the Covid-19 pandemic that hit Indonesia. In connection with the condition of the spread of Covid-19 which is still increasing, KKM implementation activities in Kesugengan Kidul village, Depok Subdistrict, Cirebon Regency must certainly be creative in order to stay safe and the purpose of activities is achieved. Starting from student fielding and data collection of partnership problems by applying health protocols properly. The method of carrying out activities is carried out with various efforts, including by providing education through leaflets, brochures, sticking brochures on the walls of elementary schools, by limiting the implementation of learning activities, provide education and examples of vitamins both tablets and derived from fruit in the form of nutritious foods that the body needs during the Covid-19 pandemic, even educating through door to door method to local citizen. Expectation of understanding and insight of citizens in the place of KKM partnerships are increasing about the prevention of Covid-19. The results and benefits of KKM activities towards partnerships include increasing public awareness of the prevention of Covid-19, one of which understands the importance of using masks, especially 2-layer masks. The community is more cooperative towards the efforts and programs of village officials to prevent the increase in the spread of the Covid-19 virus, increased citizen insight in partnership on vitamins needed and useful to increase endurance to fight covid-19 and discipline to implement health protocols in an effort to prevent and suppress the spread of Covid-19 in the partnership area of Kesugengan Kidul Village, Depok Subdistrict, Cirebon Regency.
Increasing The Appreciation Of Fine Art Through Participatory Murals At Perum Arjamukti Singaparna, Tasikmalaya Regency
Authors: Husen Wan Ridwan , Wasta Asep , Setiaji Denden , Apriani Arni , Nur Agi Fajri , Safaat Helda , Utami Mega , Imardhea Widya , Munajab Alfi
Published: January 2022

This paper aims to provide an overview of activities that seek to bring the process of art education directly to the public Community service that started from a discussion between lecturers and youth youth organizations at Perum Arjamukti Kencana in building a tourist village area around Singaparna, Tasikmalaya Regency, from this discussion arose a desire to create activities that involve residents and youth youth groups in arts-related activities. A participatory mural is a mural activity that involves the participation of citizens in its implementation, both before implementation, in its manufacture and after its creation. The method used in this research is descriptive method. The descriptive method used to increase the appreciation of fine arts through participatory murals at Perum Arjamukti Singaparna, Tasikmalaya Regency. The results obtained from research that have been carried out by residents' wishes in the mural participation process are varied, the forms of citizen participation are not only in the form of trying to scratch koas on walls to produce mural images, there are also those who participate in providing consumption, raw materials, documenting works through social media or simply just talking and taking selfies on existing murals.
EFEKTIFITAS ABDOMINAL STRETCHING EXERCISE TERHADAP PENURUNAN INTENSITAS NYERI DISMENORE PADA REMAJA PUTRI
Authors: Suganda Alpia Rahmawati , Septiani N Tatu , Nuryuniarti Rissa
Published: January 2022

Dismenore merupakan rasa nyeri yang terjadi sebelum atau selama menstruasi yang sangat menyiksa bagi wanita. Sehingga tidak terjadi metabolisme anaerob (seperti glikolisis dan glikogenolisis) yang akan menghasilkan asam laktat, dimana jika terjadi penumpukan asam laktat akan menyebabkan kelelahan, nyeri atau kram pada otot. Laporan ini bertujuan untuk mengetahui manajemen pada nyeri dismenore secara non_farmakologi. Dalam metode yang dilakukan adalah studi literatur dengan mengkaji 6 artikel penelitian. Pencarian jurnal artikel secara elektronik dengan menggunakan database google scholar.Dengan dilakukannya abdominal stretching exercise kurang lebih 10-15 menit selama 2 hari dilakukan pada hari pertama dan kedua menstruasi bagi wanita yang mengalami menstruasi akan meredakan nyeri menghasilkan relaksasi dan memperbaiki sirkulasi. Hasil study literature mengungkapkan bahwa manajemen untuk mengurangi nyeri dismenore yaitu dengan teknik abdominal stretching exercise.
DUKUNGAN KELUARGA DAN PERSONAL HYGIENE PADA PASIEN STROKE DI RUMAH SAKIT MITRA HUSADA PRINGSEWU
Authors: Fadhilah Nur , Pangestuti Lusiyana , Ardina Rani
Published: January 2022

Stroke merupakan penyebab umum kematian ke tiga di Negara maju setelah penyakit kardiovaskular dan kanker. Stroke terjadi karena ada gangguan aliran darah ke bagian otak. Bentuknya dapat berupa lumpuh sebelah (hemiplegia), berkurangnya kekuatan sebelah anggota tubuh (hemiparesis), akibat lanjut pasien mengalami gangguan kebersihan diri (personal hygiene). Dorthea Orem menjelaskan bahwa perawatan diri merupakan kegiatan memenuhi kebutuhan dalam mempertahankan kehidupan, kesehatan dan kesejahteraan individu baik dalam keadaan sehat maupun sakit. Model Orem diperluas dari perawatan individu menjadi perawatan keluarga. Salah satu faktor yang mempengaruhi kebutuhan pemenuhan kebersihan diri menurut Orem adalah sistem keluarga. Tujuan penelitan ini adalah diketahuinya  hubungan dukungan keluarga dengan personal hygiene pada pasien stroke di Ruang Rawat Inap Rumah Sakit Mitra Husada Pringsewu Tahun 2020. Jenis penelitian ini menggunakan metode analitik dengan pendekatan cross sectional.  Populasi  berjumlah 83 orang dan sampel 69 orang dengan teknik sampling accidental sampling. Alat pengumpul data menggunakan kuesioner dan lembar observasi kemudian dianalisis menggunakan chi square. Hasil penelitian menunjukkan bahwa terdapat hubungan yang signifikan (p-value = 0,000) dukungan keluarga dengan personal hygiene pada  Pasien Stroke. Pemberian perawatan yang komprehensif sebaiknya melibatkan peran serta keluarga,  hal ini sejalan dengan tugas keluarga yaitu memberikan perawatan pada angota keluarga yang mengalami masalah kesehatan.
PENGARUH AKTIVITAS FISIK JALAN KAKI TERHADAP GULA DARAH SEWAKTU PENDERITA DIABETES MELITUS TIPE 2 DI WILAYAH KERJA PUSKESMAS KOTADALAM PESAWARAN TAHUN 2021
Authors: Supriyanto Heru , Vellyana Diny , Stiawan Diki
Published: January 2022

Pendahuluan :DM Tipe 2 yang tak tergantung pada insulin disebabkan insulin yang ada tidak dapat bekerja dengan baik, tetapi fungsi insulin untuk metabolisme glukosa tidak ada/kurang dan biasanya diketahui DM setelah usia 40 tahun (Hadibroto, 2013). Komplikasi mikrovaskular (retinopati, nefropati, neuropati) dan komplikasi makrovaskular (aterosklerotik, stroke, angina, infark miokardium, gangren).Penatalaksanaan penderita DM dapat dilakukan dengan kegiatan jasmani secara teratur 3 sampai 5 hari seminggu selama sekitar 30 sampai 45 menit, latihan jasmani yang di anjurkan salah satu nya jalan kaki. Tujuan penelitian diketahui pengaruh aktivitas fisik jalan kaki terhadap gula darah sewaktu pada penderita DM Tipe 2. Metode :Desain penelitianpre-eksperiment one group pre-test-posttest. Sampel 16 penderita DM  tipe 2 denganpurposive sampling dan observasi langsung dengan mengukur kadar gula darah menggunakan Gluko DR AGM 2100 dan analisis statistik Uji dependent sampel T test. Hasil:nilai p-value sebesar 0,000 dengan rata-rata kadar gula darah sebesar 273,44 mg/ dl dan sesudah dilakukan aktivitas fisik jalan kaki sebesar 170,88 mg/ dl. Pembahasan :Kesimpulan ada pengaruh aktivitas fisik terhadap gula darah sewaktu pada penderita diabetes melitus Tipe 2 dan disarankan melakukan aktifitas jalan kaki sesuai prosedur saat menuju kebun ataupun sawah sehingga keseimbangan kadar gula darah tetap terjaga.
GAMBARAN TINGKAT RISIKO PENYAKIT KARDIOVASKULAR BERDASARKAN SKOR KARDIOVASKULAR JAKARTA
Authors: Rosidawati Ida , Aryani Hana
Published: January 2022

Penyakit kardiovaskular masih menjadi masalah kesehatan global di dunia termasuk Indonesia. Hal tersebut dapat meningkatkan angka kesakitan, kecacatan dan beban sosial ekonomi.  Oleh karena itu, diperlukan deteksi dini risiko penyakit kardiovaskuler menggunakan skor kardiovaskular Jakarta sehingga dapat dikaji lebih lanjut, dimonitoring dan diberikan intervensi yang tepat. Penelitian ini bertujuan untuk menggambarkan tingkat risiko penyakit kardiovaskuler berdasarkan skor kardiovaskuler Jakarta. Jenis penelitian deskriptif kuantitatif dengan sampel berjumlah 30 orang menggunakan teknik accidental sampling. Pengumpulan data menggunakan lembar observasi berdasarkan skor kardiovaskuler Jakarta kemudian di analisis secara univariat. Hasil penelitian menunjukkan tingkat risiko penyakit kardiovaskular responden berdasarkan skor kardiovaskuler jakarta antara tingkat risiko rendah (43%) dan tinggi (40%) berbeda tipis. Peneliti berasumsi bahwa hal tersebut dipengaruhi oleh beberapa faktor yang menjadi kriteria dalam penilaiannya, sebagaimana data yang ditemukan yakni semua responden adalah perempuan (100%), sebagian besar rentang usia adalah diatas 60 tahun (30%), mayoritas memiliki tekanan darah normal (66,7%), indeks massa tubuh pada kisaran 26,00-29,99 (46,7%), tidak merokok (100%), tidak menderita diabetes mellitus (90%), dan melakukan aktivitas fisik sedang (46,7%). Kesimpulan Sebagian besar responden memiliki tingkat risiko penyakit kardiovaskular yang rendah dan tinggi hampir sama, sehingga manajemen faktor risiko tetap perlu dilakukan terutama pada kelompok dengan risiko tinggi.
Adaptasi Pembelajaran Seni Budaya Berbasis Kolaboratif Masyarakat Pada Masa Darurat Covid 19
Authors: Kosasih Ceceng
Published: January 2022

This article is the result of a study of the learning system developed during the emergency of the COVID-19 pandemic. The concept of collaborative learning with the community is an alternative and is allegedly able to complement the deficiencies in the distance learning process carried out with online, offline or semi-network systems. , with various obstacles it faces.
Seni Terebang Gebes Dalam Prosesi Ritual Hajat Lembur pada Grup Candralijaya di Kecamatan Tanjungjaya Kabupaten Tasikmalaya
Authors: Deniati Leli , Setiaji Denden
Published: January 2022

Penelitian ini bertujuan untuk mengetahui dan mendeskripsikan tentang seni terebang gebes dalam prosesi ritual hajat lembur pada Grup Candralijaya di Kecamatan Tanjungjaya Kabupaten Tasikmalaya, yang mengkaji permasalahan tentang bagaimana mengenai struktur penyajian seni serta peran dan fungsi seni terebang gebes pada hajat lembur. Jenis penelitian ini adalah penelitian deskriptif analitik dengan pendekatan kualitatif. Data yang diperoleh adalah dengan teknik observasi, wawancara, dan dokumentasi. Instrumen utama dalam penelitian ini adalah peneliti itu sendiri menggunakan alat bantu berupa lembar wawancara, catatan lapangan, dan alat rekam berupa handphone. Temuannya mengenai struktur penyajian musik terebang gebes Grup Candralijaya dalam rangkaian ritual hajat lembur yang terbagi kedalam tiga bagian meliputi bagian pembuka pertunjukan, bagian isi dan penutup. Sedangkan peran dan fungsi seni diklasifikasikan menjadi fungsi primer yaitu sebagai sarana ritual, ungkapan pribadi dan presentasi estetis.
STRATEGIC DEVELOPMENT AREAS OF THE REGIONAL AGRI-FOOD SYSTEMS IN THE CONTEXT OF PROVISION OF FOOD SAFETY OF THE POPULATION
Authors: Sutygina A.I. , Ovchinnikova A.V. , Bratsikhin A.A.
Published: January 2022

Strategic goal of agri-food systems development (AFS) is provision of food safety of the country. This predetermines food sovereignty of the country on the national level. It is important for regions to achieve self-sufficiency in food. Food safety of each country resident is characterized by the balanced and quality nutrition in the volume no less than the norm of rational consumption. To achieve the food sovereignty on every of the above-mentioned levels, it's necessary to have stable development of the regional agri-food systems where the demand, supply and consumption of the food products form. Functioning of AFS is connected with the efficiency of agri-food production, its competitiveness, trading networks activity, population incomes and participance of the state in the forming of food supply and the demand. The role of the state regulation consists in the forming of conditions for the stable functioning of all its sub-systems, provision of physical, economic and social availability of the food. In conditions of the differentiation of the regions by social and economical development, the level of the population incomes and food prices are varied significantly. This stipulates different levels of the affordability of the food. Besides, economic inequality is noted not only among regions, but also among the employees of different economic sectors, as well as residents of city and rural settlements. In these conditions self-provision of the population with food is a factor of increase of the nutrition quality, and the realization of the excess is a source of additional incomes. State support of the owners of private part-owner units, activity of trading and purchasing consumer co-operatives contribute to the growth of self-sufficiency of the villagers with food.
MEDIATION IN BRIBERY: CURRENT PROBLEMS OF LAW ENFORCEMENT
Authors: Zvarygin V.E. , Kondakov A.S.
Published: January 2022

This article provides a complete and comprehensive analysis of the norms of legislation regulating the issues of combating corruption crimes on the example of mediation in bribery. Using the comparative legal method of scientific cognition, the main national normative legal acts regulating the fight against corruption, as well as normative legal acts of the Soviet period, are analyzed. The scientific article also analyzes the provisions of federal laws and by-laws of state authorities regulating the issues we have raised. In addition, the analysis of the law enforcement practice of law enforcement agencies and courts responsible for the organization of work on the identification, prevention and suppression of corruption crimes, as well as criminal prosecution for their commission, has been carried out. The article also reveals the law enforcement and other problems of bringing to criminal responsibility for mediation in bribery, the promise of mediation in bribery and "imaginary mediation", the criminal law analysis of these crimes by their elements is carried out. Based on the results of the analysis, proposals aimed at further improving the regulatory framework relating to the issues of countering corruption crimes have been derived.
ON THE RELEVANCE OF THE DEVELOPMENT OF PROCEDURES IN PRE-TRIAL PROCEEDINGS APPLICABLE UNDER ARTICLES 25, 25.1, 28 PART 1, 28.1 OF THE CRIMINAL PROCEDURE CODE OF THE RUSSIAN FEDERATION, AND THEIR CLASSIFICATION
Authors: Tarsheva M.N.
Published: January 2022

Legal procedures in a state governed by the rule of law are a kind of guarantor of legality and protection of citizens' rights, and therefore issues related to the development and improvement of the procedural mechanism are among the top priorities. The procedural mechanism is the most important structural element of the legal regulation system, which includes entire procedural branches. The article substantiates the need to develop and legislate procedures within which actions can be carried out to reconcile and make amends for harm, compensation for damage or otherwise make amends for harm (since gaps and shortcomings in the legislation associated with the lack of procedural mechanisms do not allow to fully realize the human rights potential of Articles 25, 25.1, 28 Part 1, 28.1 of the Criminal Procedure Code of the Russian Federation), as well as the need to classify these procedures (which has not been previously carried out). The author proposes to divide such procedures into conciliatory and restorative ones. The author's definitions of conciliation and restorative procedures in pre-trial proceedings are given.
PROBATION PERIOD AS A MEANS OF IMPLEMENTING THE FUNCTIONS OF CONDITIONAL SENTENCE
Authors: Medvedev E.V.
Published: January 2022

The paper reveals the functional purpose of the norms regulating the procedure for establishing, extending and canceling the probation period on the grounds provided for in Article 74 of the Criminal Code, and determines their place in the mechanism for implementing the protective and restorative functions of criminal law. In the course of the study, the author comes to the conclusion that it is necessary to make a number of changes to this procedure, in particular, concerning the assessment of the grounds and determination of the legal consequences of the cancellation of probation as a result of the commission of an administrative offense by a conditionally convicted person, careless and intentional crimes, as well as violations of the requirements established for the behavior of a convicted person for the period of probation by a court verdict. At the same time, when designing the norms on probation, the legislator should proceed from the fact that the maximum effect of using this tool depends on the degree of integration of the convict's personality into a socially oriented environment, including in terms of correcting his value-semantic attitudes. It can be achieved if the probationer takes part in the life of society on an equal basis with its other representatives, being in the same social status and legal position with them, that is, in conditions of equal opportunities. Therefore, the longer a person is in the status of a convicted (albeit conditionally convicted) and a judged person, the further the prospect of full-fledged re-socialization will move away from him.
Development of knowledge-based resources in Ukraine
Authors: Chmyr О. S.
Published: January 2022

The article considers the concept of open science. The brief overview of different approaches to its interpretation is provided, the components and principles of implementation are given. One of the key elements of open science is an open scientific infrastructure, in particular — knowledge-based resources – scientific archives, platforms, repositories. Without proper attention from the scientific and educational community, as well as the state, it is impossible to ensure their proper development. After all, any infrastructure requires constant support aimed at ensuring the proper functioning and modernization in accordance with world best practices. In this regard, Ukraine needs political solutions that support the establishment of open science. They, in its turn, should be implemented through a project approach to individual infrastructure (including the National Repository of Academic Texts) and through the introduction of a common framework, standard guidelines, proven approaches, and established practices that can be scaled within the state, extended to institutions of scientific and educational sphere. The article examines in detail the project of creating a National Repository, as well as identifies promising areas for its development.
Innovative efficiency of European countries and Ukraine according to the evaluation of the European innovation board
Authors: Koreniako H. I. , Maltsev V. S.
Published: January 2022

Development of most countries depends on an effective innovation policy. Monitoring the innovation efficiency of both individual countries and the European Union as a whole is an integral part of decision-making to improve innovation policy. The European Commission’s annual report “European Innovation Scoreboard” for each EU member state and some other European countries provides indicators that characterize the differences and dynamics of innovation indicators. The methodology of the European Innovation Scoreboard, the composition and number of indicators are constantly changing. The article analyzes the results of the evaluation of innovation efficiency of countries taking into account the changes that have occurred in the methodology of the European Innovation Scoreboard in 2021 and the results of the evaluation of Ukraine against the European countries. There was a decrease of 5.3 % — to 29.8 % — of the consolidated Innovation Index of Ukraine for 2014–2021 compared to the EU in 2014. An analysis of the strengths and weaknesses of the innovation system of Ukraine is provided. Since domestic statistics is not available for all indicators, the data obtained for Ukraine is “less reliable”. Ukraine needs to improve its statistical survey of innovation and to radically revisit innovation policy.
Eneolitický kostrový pohřební ritus na Moravě ve světle radiokarbonového datování / The Eneolithic inhumation burial rite in Moravia in light of radiocarbon dating
Authors: Trampota František , Bíšková Jarmila , Čerevková Alžběta , Čižmář Ivan , Drozdová Eva , Kala Jiří , Kos Petr , Květina Petr , Parma David , Přichystal Michal , Světlík Ivo , Šín Lukáš , Tvrdý Zdeněk , Vrána Jakub
Published: January 2022

The article addresses the chronology of Eneolithic inhumation burials in Moravia based on radiocarbon dating. A total of 17 individuals were dated using 20 radiocarbon dates, primarily individuals without grave goods or individuals from problematic contexts. The study mainly covers the period of the Early Eneolithic, to a lesser extent the Middle and Late Eneolithic. The find contexts and anthropological assessments are newly published for most of the burials in question. Based on the chronological analysis of graves dated by radiocarbon dating, it is possible to approximately define the time dispersion of individual burial methods in Moravia. Flat graves with individuals in a stretched position without grave goods can be most reliably dated to about 3800–3600 BC.
The North or the South? Early medieval ceramics decorated with a zoned ornament – the result of local changes or interregional contacts?
Authors: Kolenda Justyna , Zamelska-Monczak Kinga
Published: January 2022

The article underlines the need to re-discuss the prevailing views in archaeological literature on the provenance and transformation stages of completely wheel-turned ceramics decorated with zoned ornament. This class of ceramics was used in the Early Middle Ages (for about 100 years) by communities living in the area of southern Greater Poland and the north-eastern part of Lower Silesia. The previous ideas suggesting a close relationship between zoned ceramics and vessels produced in northern Bohemia are reconsidered, with the internal diversity of zoned ceramics being pointed out. We argue that inspiration in ceramics manufacturing came not only from the south (Bohemia), but also from the north (Pomerania) and the west (the middle Elbe region), and that there were also changes that appeared independently of these impulses in the ceramics production of small, native communities.
Organic monolayers modified by vacuum ultraviolet irradiation for solution-processed organic thin-film transistors
Authors: Inoue Satoshi , Hattori Yoshiaki , Kitamura Masatoshi
Published: January 2022

A trimethylsilyl-monolayer modified by vacuum ultraviolet (VUV) light has been investigated for use in solution-processed organic thin-film transistors (OTFTs). The VUV irradiation changed a hydrophobic trimethylsilyl-monolayer formed from hexamethyldisilazane vapor into a hydrophilic surface suitable for solution processing. The treated surface was examined via water contact angle measurement and X-ray photoelectron spectroscopy. An appropriate irradiation of VUV light enabled the formation of a dioctyl[1]benzothieno[3,2-b][1]benzothiophene (C8-BTBT) film on a modified monolayer by spin-coating. Consequently, the C8-BTBT-based OTFT with a monolayer modified for an optimal VUV irradiation time exhibited a field-effect mobility up to 4.76 cm2 V−1 s−1. The partial monolayer modification with VUV can be adapted to a variety of solution-processes and organic semiconductors for prospective printed electronics.
A Disturbance Suppression Micro-Newton Force Sensor Based on Shadow Method
Authors: Yang Yong , Zhao Meirong , Li Dantong , Tao Moran , Zhu Chunyuan , Zheng Yelong , Tian Yu
Published: January 2022

The precision of micro-force measurement is determined by the sensitivity of force sensors and the magnitude of environmental disturbances. Damping, a process that converts vibrational energy into heat, is one of the most effective methods of suppressing disturbances. Inspired by the shadow formed at a pond when water striders walked on the water, a bionic viscoelastic-polymer micro-force (VPMF) sensor with a high damping ratio based on the shadow method was developed. In the VPMF sensor, the surface of the polymer was deformed by the contact of a cylindrical flat punch when the sensor was subjected to a normal force. A shadow with a bright edge was formed due to the refraction that parallel light went through the deformed surface. The force was in proportion to the change of the shadow diameter. The sensor optimal sensitivity was 2.15 μN/pixel and the measurement range was 0.981 mN. The damping ratio of the VPMF sensor was 0.22 on account of viscoelasticity, which could suppress disturbances effectively. The VPMF sensor could reduce the influence of disturbances by about 96.23% compared to the cantilever. The present study suggests that the VPMF sensor is hopefully applied to the reliable measurement of micro force under complex environments.
The Impact of a Paraelectric layer in the FE/DE Stack on Performance of NCFET
Authors: Kansal Harshit , Medury Aditya S
Published: January 2022

In this letter, through TCAD simulations, we show that the introduction of a thin paraelectric (PE) layer between the ferroelectric (FE) and dielectric (DE) layers in an MFIS structure, expands the design space for the FE layer enabling hysteresis-free and steep subthreshold behavior, even with a thicker FE layer. This can be explained by analyzing the FE-PE stack from a capacitance perspective where the thickness of the PE layer in the FE-PE stack has the effect of reducing the FE layer thickness, while also reducing the remnant polarization. Finally, for the same FE-PE-DE stack, analog performance parameters such as $\frac{g_{m}} g_{ds}}$ and $\frac{g_{m}}{I_{d}}$ are analyzed, showing good characteristics over a wide range of gate lengths, at low drain voltages, thus demonstrating applicability for low power applications.