bluuebunny/crossref_metadata_2025 huggingface dataset:
Selective nematocidal effects of essential oils from two cultivated Artemisia absinthium populations
Authors: García-Rodríguez Juan José , Andrés María-Fé , Ibañez-Escribano Alexandra , Julio Luis F. , Burillo Jesús , Bolás-Fernández Francisco , González-Coloma Azucena
Published: October 2015

Essential oils (EOs) obtained from two crops and populations of thujone-free cultivated Artemisia absinthium were tested against two nematode models, the mammalian parasite Trichinella spiralis, and the plant parasitic root knot nematode Meloidogyne javanica. The EOs were characterized by the presence of (Z)-epoxyocimene and chrysanthenol as major components and showed time and population dependent quantitative and qualitative variations in composition. The EOs showed a strong ex vivo activity against the L1 larvae of the nematode Trichinella spiralis with a reduction of infectivity between 72 and 100% at a dose range of 0.5–1 mg/ml in absence of cytotoxicity against mammalian cells. Moreover, the in vivo activity of the EO against T. spiralis showed a 66% reduction of intestinal adults. However, these oils were not effective against M. javanica.
In VivoReprogramming for Brain and Spinal Cord Repair
Authors: Chen Gong , Wernig Marius , Berninger Benedikt , Nakafuku Masato , Parmar Malin , Zhang Chun-Li
Published: October 2015

Cell reprogramming technologies have enabled the generation of various specific cell types including neurons from readily accessible patient cells, such as skin fibroblasts, providing an intriguing novel cell source for autologous cell transplantation. However, cell transplantation faces several difficult hurdles such as cell production and purification, long-term survival, and functional integration after transplantation. Recently,in vivoreprogramming, which makes use of endogenous cells for regeneration purpose, emerged as a new approach to circumvent cell transplantation. There has been evidence forin vivoreprogramming in the mouse pancreas, heart, and brain and spinal cord with various degrees of success. This mini review summarizes the latest developments presented in the first symposium onin vivoreprogramming glial cells into functional neurons in the brain and spinal cord, held at the 2014 annual meeting of the Society for Neuroscience in Washington, DC.
Developmental RacGAP α2-Chimaerin Signaling Is a Determinant of the Morphological Features of Dendritic Spines in Adulthood
Authors: Iwata Ryohei , Matsukawa Hiroshi , Yasuda Kosuke , Mizuno Hidenobu , Itohara Shigeyoshi , Iwasato Takuji
Published: October 2015

Morphological characteristics of dendritic spines form the basis of cognitive ability. However, molecular mechanisms involved in fine-tuning of spine morphology during development are not fully understood. Moreover, it is unclear whether, and to what extent, these developmental mechanisms determine the normal adult spine morphological features. Here, we provide evidence that α2-isoform of Rac-specific GTPase-activating protein α-chimaerin (α2-chimaerin) is involved in spine morphological refinement during late postnatal period, and furthermore show that this developmental α2-chimaerin function affects adult spine morphologies. We used a series of mice with global and conditional knock-out of α-chimaerin isoforms (α1-chimaerin and α2-chimaerin). α2-Chimaerin disruption, but not α1-chimaerin disruption, in the mouse results in an increased size (and density) of spines in the hippocampus. In contrast, overexpression of α2-chimaerin in developing hippocampal neurons induces a decrease of spine size. Disruption of α2-chimaerin suppressed EphA-mediated spine morphogenesis in cultured developing hippocampal neurons. α2-Chimaerin disruption that begins during the juvenile stage results in an increased size of spines in the hippocampus. Meanwhile, spine morphologies are unaltered when α2-chimaerin is deleted only in adulthood. Consistent with these spine morphological results, disruption of α2-chimaerin beginning in the juvenile stage led to an increase in contextual fear learning in adulthood; whereas contextual learning was recently shown to be unaffected when α2-chimaerin was deleted only in adulthood. Together, these results suggest that α2-chimaerin signaling in developmental stages contributes to determination of the morphological features of adult spines and establishment of normal cognitive ability.

SIGNIFICANCE STATEMENTRecent studies of neurodevelopmental disorders in humans and their animal models have led to an attractive hypothesis that spine morphogenesis during development forms the basis of adult cognition. In particular, the roles of Rac and its regulators, such as Rac-specific GTPase-activating proteins (RacGAPs) and Rac guanine nucleotide exchange factors, are a topic of focus in spine morphogenesis and cognitive ability. Using a series of mice with global and conditional knock-out (KO) of RacGAP α-chimaerin isoforms (α1-chimaerin and α2-chimaerin), we provide compelling evidence demonstrating that α2-chimaerin is involved in spine morphological refinement during late postnatal development and that this developmental α2-chimaerin function affects adult spine morphologies. Furthermore, our results clearly showed that α2-chimaerin signaling during late postnatal development contributes to normal cognitive ability in adult mice.
Downregulation of Sphingosine 1-Phosphate Receptor 1 Promotes the Switch from Tangential to Radial Migration in the OB
Authors: Alfonso Julieta , Penkert Horst , Duman Ceren , Zuccotti Annalisa , Monyer Hannah
Published: October 2015

Neuroblast migration is a highly orchestrated process that ensures the proper integration of newborn neurons into complex neuronal circuits. In the postnatal rodent brain, neuroblasts migrate long distances from the subependymal zone of the lateral ventricles to the olfactory bulb (OB) within the rostral migratory stream (RMS). They first migrate tangentially in close contact to each other and later radially as single cells until they reach their final destination in the OB. Sphingosine 1-phosphate (S1P) is a bioactive lipid that interacts with cell-surface receptors to exert different cellular responses. Although well studied in other systems and a target for the treatment of multiple sclerosis, little is known about S1P in the postnatal brain. Here, we report that the S1P receptor 1 (S1P1) is expressed in neuroblasts migrating in the RMS. Usingin vivoandin vitrogain- and loss-of-function approaches in both wild-type and transgenic mice, we found that the activation of S1P1 by its natural ligand S1P, acting as a paracrine signal, contributes to maintain neuroblasts attached to each other while they migrate in chains within the RMS. Once in the OB, neuroblasts cease to express S1P1, which results in cell detachment and initiation of radial migration, likely via downregulation of NCAM1 and β1 integrin. Our results reveal a novel physiological function for S1P1 in the postnatal brain, directing the path followed by newborn neurons in the neurogenic niche.

SIGNIFICANCE STATEMENTThe function of each neuron is highly determined by the position it occupies within a neuronal circuit. Frequently, newborn neurons must travel long distances from their birthplace to their predetermined final location and, to do so, they use different modes of migration. In this study, we identify the sphingosine 1-phosphate (S1P) receptor 1 (S1P1) as one of the key players that govern the switch from tangential to radial migration of postnatally generated neuroblasts in the olfactory bulb. Of interest is the evidence that the ligand, S1P, is provided by nearby astrocytes. Finally, we also propose adhesion molecules that act downstream of S1P1 and initiate the transition from tangential chain migration to individual radial migration outside of the stream.
Store-Operated Calcium Entry through Orai Is Required for Transcriptional Maturation of the Flight Circuit inDrosophila
Authors: Pathak Trayambak , Agrawal Tarjani , Richhariya Shlesha , Sadaf Sufia , Hasan Gaiti
Published: October 2015

Store operated calcium entry (SOCE) is thought to primarily regulate calcium homeostasis in neurons. Subsequent to identification of Orai as the SOCE channel in nonexcitable cells, investigation of Orai function in neurons demonstrated a requirement for SOCE inDrosophilaflight. Here, by analysis of anOraimutant and by controlled expression of a dominant-negativeDrosophila Oraitransgene, we show that Orai-mediated SOCE is required in dopaminergic interneurons of the flight circuit during pupal development. Expression of dominant-negativeOraiin dopaminergic neurons of pupae abolished flight. The loss of Orai-mediated SOCE alters transcriptional regulation of dopaminergic neurons, leading to downregulation of the enzyme tyrosine hydroxylase, which is essential for dopamine synthesis, and the dopamine transporter, which is required for dopamine uptake after synaptic release. These studies suggest that modulation of SOCE could serve as a novel mechanism for restoring dopamine levels in dopaminergic neurons.

SIGNIFICANCE STATEMENTThe specificity of an animal's response to an environmental stimulus is determined in part by the release of neurotransmitters, which are sensed by responding neurons through cognate receptors on their surface. One way by which neurons respond is through release of calcium from intracellular stores followed by store refilling from extracellular calcium sources. This mechanism is called store-operated calcium entry (SOCE). The function of SOCE in neurons has been debated. Here we describe a new function for SOCE in the regulation of neurotransmitter levels inDrosophilaflight neurons. This cell-signaling mechanism is required to maintain optimal levels of a key enzyme for dopamine synthesis and may serve as a mechanism for restoring dopamine levels in relevant pathological conditions.
Increased Dosage of High-Affinity Kainate Receptor Genegrik4Alters Synaptic Transmission and Reproduces Autism Spectrum Disorders Features
Authors: Aller M. Isabel , Pecoraro Valeria , Paternain Ana V. , Canals Santiago , Lerma Juan
Published: October 2015

The understanding of brain diseases requires the identification of the molecular, synaptic, and cellular disruptions underpinning the behavioral features that define the disease. The importance of genes related to synaptic function in brain disease has been implied in studies describingde novogermline mutations and copy number variants. Indeed,de novocopy number variations (deletion or duplication of a chromosomal region) of synaptic genes have been recently implicated as risk factors for mental retardation or autism. Among these genes isGRIK4, a gene coding for a glutamate receptor subunit of the kainate type. Here we show that mice overexpressinggrik4in the forebrain displayed social impairment, enhanced anxiety, and depressive states, accompanied by altered synaptic transmission, showing more efficient information transfer through the hippocampal trisynaptic circuit. Together, these data indicate that a single gene variation in the glutamatergic system results in behavioral symptomatology consistent with autism spectrum disorders as well as in alterations in synaptic function in regions involved in social activity. Autistic features of these mice represent powerful tools for improving diagnosis and testing of specific treatments targeting abnormalities in glutamatergic signaling related to autism spectrum disorders.

SIGNIFICANCE STATEMENTA genetic overlap exists between autism spectrum disorders (ASD), currently thought to represent a continuum of the same disorder with varying degrees of severity, and other neurodevelopmental and neuropsychiatric endophenotypes. We show that the duplication of a single gene coding for a high-affinity kainate receptor subunit (i.e.,grik4) in a limited area of the brain recapitulates behavioral endophenotypes seen in humans diagnosed with autism (anhedonia, depression, anxiety, and altered social interaction), including some humans withGRIK4duplications. Therefore, it should be possible to use mice overexpressinggrik4to directly address circuit dysfunctions associated with ASDs and test specific treatments of autism-related behaviors.
The Stimulus-Dependent Gradient of Cyp26B1+Olfactory Sensory Neurons Is Necessary for the Functional Integrity of the Olfactory Sensory Map
Authors: Login Hande , Håglin Sofia , Berghard Anna , Bohm Staffan
Published: October 2015

Stimulus-dependent expression of the retinoic acid-inactivating enzyme Cyp26B1 in olfactory sensory neurons (OSNs) forms a dorsomedial (DM)–ventrolateral (VL) gradient in the mouse olfactory epithelium. The gradient correlates spatially with different rates of OSN turnover, as well as the functional organization of the olfactory sensory map, into overlapping zones of OSNs that express different odorant receptors (ORs). Here, we analyze transgenic mice that, instead of a stimulus-dependent Cyp26B1 gradient, have constitutive Cyp26B1 levels in all OSNs. Starting postnatally, OSN differentiation is decreased and progenitor proliferation is increased. Initially, these effects are selective to the VL-most zone and correlate with reduced ATF5 expression and accumulation of OSNs that do not express ORs. Transcription factor ATF5 is known to stabilize OR gene choice via onset of the stimulus-transducing enzyme adenylyl cyclase type 3. During further postnatal development of Cyp26B1 mice, an anomalous DMhigh–VLlowexpression gradient of adenylyl cyclase type 3 appears, which coincides with altered OR frequencies and OR zones. All OR zones expand ventrolaterally except for the VL-most zone, which contracts. The expansion results in an increased zonal overlap that is also evident in the innervation pattern of OSN axon terminals in olfactory bulbs. These findings together identify a mechanism by which postnatal sensory-stimulated vitamin A metabolism modifies the generation of spatially specified neurons and their precise topographic connectivity. The distributed patterns of vitamin A-metabolizing enzymes in the nervous system suggest the possibility that the mechanism may also regulate neuroplasticity in circuits other than the olfactory sensory map.

SIGNIFICANCE STATEMENTThe mouse olfactory sensory map is functionally wired according to precise axonal projections of spatially organized classes of olfactory sensory neurons in the nose. The genetically controlled mechanisms that regulate the development of the olfactory sensory map are beginning to be elucidated. Little is known about mechanisms by which sensory stimuli shape the organization of the map after birth. We show that a stimulus-dependent gradient of a retinoic acid-inactivating enzyme Cyp26B1 modifies the composition, localization, and axonal projections of olfactory sensory neuron classes. The mechanism is novel and suggests the interesting possibility that local vitamin A metabolism could also be a mediator of stimulus-dependent modifications of precise spatial connectivity in other parts of the nervous system.
Functional Diversity of Subicular Principal Cells during Hippocampal Ripples
Authors: Böhm Claudia , Peng Yangfan , Maier Nikolaus , Winterer Jochen , Poulet James F.A. , Geiger Jörg R.P. , Schmitz Dietmar
Published: October 2015

Cortical and hippocampal oscillations play a crucial role in the encoding, consolidation, and retrieval of memory. Sharp-wave associated ripples have been shown to be necessary for the consolidation of memory. During consolidation, information is transferred from the hippocampus to the neocortex. One of the structures at the interface between hippocampus and neocortex is the subiculum. It is therefore well suited to mediate the transfer and distribution of information from the hippocampus to other areas. By juxtacellular and whole-cell-recordings in awake mice, we show here that in the subiculum a subset of pyramidal cells is activated, whereas another subset is inhibited during ripples. We demonstrate that these functionally different subgroups are predetermined by their cell subtype. Bursting cells are selectively used to transmit information during ripples, whereas the firing probability in regular firing cells is reduced. With multiple patch-clamp recordingsin vitro, we show that the cell subtype-specific differences extend into the local network topology. This is reflected in an asymmetric wiring scheme where bursting cells and regular firing cells are recurrently connected among themselves but connections between subtypes exclusively exist from regular to bursting cells. Furthermore, inhibitory connections are more numerous onto regular firing cells than onto bursting cells. We conclude that the network topology contributes to the observed functional diversity of subicular pyramidal cells during sharp-wave associated ripples.

SIGNIFICANCE STATEMENTMemory consolidation is dependent on hippocampal activity patterns, so called hippocampal ripples. During these fast oscillations, memory traces are transferred from the hippocampus to the neocortex via the subiculum. We investigated the role of single cells in the subiculum during ripples and found that, dependent on their subtype, they are preferentially activated or inhibited. In addition, these two subtypes, the bursting and regular firing type, are differentially integrated into the local network: inhibitory cells are more densely connected to regular firing cells, and communication between regular and bursting cells is unidirectional. Together with earlier findings on different preferential target regions of these subtypes, we conclude that memory traces are guided to target regions of the activated cell type.
Tc1-like TransposaseThm3of Silver Carp (Hypophthalmichthys molitrix) Can Mediate Gene Transposition in the Genome of Blunt Snout Bream (Megalobrama amblycephala)
Authors: Guo Xiu-Ming , Zhang Qian-Qian , Sun Yi-Wen , Jiang Xia-Yun , Zou Shu-Ming
Published: October 2015

Tc1-like transposons consist of an inverted repeat sequence flanking a transposase gene that exhibits similarity to the mobile DNA element, Tc1, of the nematode, Caenorhabditis elegans. They are widely distributed within vertebrate genomes including teleost fish; however, few active Tc1-like transposases have been discovered. In this study, 17 Tc1-like transposon sequences were isolated from 10 freshwater fish species belonging to the families Cyprinidae, Adrianichthyidae, Cichlidae, and Salmonidae. We conducted phylogenetic analyses of these sequences using previously isolated Tc1-like transposases and report that 16 of these elements comprise a new subfamily of Tc1-like transposons. In particular, we show that one transposon, Thm3 from silver carp (Hypophthalmichthys molitrix; Cyprinidae), can encode a 335-aa transposase with apparently intact domains, containing three to five copies in its genome. We then coinjected donor plasmids harboring 367 bp of the left end and 230 bp of the right end of the nonautonomous silver carp Thm1 cis-element along with capped Thm3 transposase RNA into the embryos of blunt snout bream (Megalobrama amblycephala; one- to two-cell embryos). This experiment revealed that the average integration rate could reach 50.6% in adult fish. Within the blunt snout bream genome, the TA dinucleotide direct repeat, which is the signature of Tc1-like family of transposons, was created adjacent to both ends of Thm1 at the integration sites. Our results indicate that the silver carp Thm3 transposase can mediate gene insertion by transposition within the genome of blunt snout bream genome, and that this occurs with a TA position preference.
CYTOMEGALOVIRUS INFECTION IN IMMUNOSUPPRESSED PATIENTS AFTER KIDNEY TRANSPLANTATION
Authors: Luscalov Simona , Loga Luminita , Dican Lucia , Junie Lia Monica
Published: October 2015

The first kidney transplantation was performed in 1951 and ever since then living donor transplantation became a more and more important solution for patients with end-stage renal disease (ESRD).Renal transplantation is a life-saving procedure. Morbidity and mortality on waiting-lists are strongly correlated with the time of dialysis and end-stage renal disease is one of the most important causes of death; this is the reason why transplantation has to be performed as soon as possible in order to reduce the time of dialysis.Once the transplantation is performed, a number of complications may occur in post-transplant evolution, the most important of which is rejection.The rejection may appear through several mechanisms, but one of the most frequent causes of rejection is cytomegalovirus (CMV) infection. It is very important to have a precocious and fast diagnosis of CMV infection in order to maintain the functionality and survival of the graft. PP65 CMV antigenemia has proven its effectiveness in detecting and monitoring the CMV infection in transplanted patients.In the laboratory of the Clinical Institute of Urology and Renal Transplantation (ICUTR) of Cluj Napoca the CMV infection is evidenced by two methods: PP65antigenemia and IgM antibody identification by chemiluminiscence.
Graphitic Schottky Contacts to Si formed by Energetic Deposition
Authors: Alnassar Mohammad Saleh N , Leech Patrick W. , Reeves Geoff K. , Holland Anthony S. , Lau Desmond W. M. , McCulloch Dougal G. , Tran Hiep N. , Partridge Jim G.
Published: October 2015

Carbon films deposited by filtered cathodic vacuum arc have been used to form high quality Schottky diodes on p-Si. Energetic deposition with an applied substrate bias of -1 kV and with a substrate temperature of 100 °C has produced carbon diodes with rectification ratios of ∼ 3 × 106, saturation currents of ∼0.02 nA and ideality factors close to unity (n = 1.05). Simulations were used to estimate the effective work function and the thickness of an interfacial mixed (C/SiO2) layer from the current/voltage characteristics of the diodes.
ACTS OF VOLITION
Authors: Harley Ross
Published: October 2015

Ross Harley's article provides a detailed study of the Australian independent record label Volition, and its role in nurturing the development of techno-dance music. In covering this topic, his study emphasises how the local can be enabled by - or even predicated on - the support of international agencies when its local industry is resistant to the development of new genres
TEMPTATION AND EXPLOITATION
Authors: Lawrance Raelene , Welsh Kerryn
Published: October 2015

Lawrance and Welsh provide a detailed study of the copyright 'loophole' which allowed live 'bootleg' recordings to be commercially produced and retailed in Australia in the early 1990s. Their study illustrates the complexity of music copyright issues in contemporary media culture and the manner in which major international players - and most particularly the USA - influence national legislation.
NEW ZEALAND MUSIC ON THE INTERNET
Authors: Mitchell Tony
Published: October 2015

Mitchell provides a detailed case study of the organisation, nature of interactions and taste agendas of the NZPOP Internet mailing list, illustrating the manner in which musical identity comes to be displaced and (re )defined through particular sets of discursive practices
BACK EAST
Authors: Mutsaers Lutgard
Published: October 2015

This article is based on extracts from Lutgard Mutsaers' book Rock:in 'Ramona (1989, The Hague: SDU)-from which all quotations are sourced-translated by Hugo De Vries and edited, annotated and expanded by Philip Hayward.
UKULELES, GUITARS OR GUMLEAVES?
Authors: Ryan Robin
Published: October 2015

Before the so-called 'Golden Age' which Hawaiian music experienced internationally from the 1930s-1950s, various visiting and locally based Australian troupes featured hula dancing as part of their acts• This short article serves as a postscript to the comprehensive studies of Hawaiian music and hula dancing in Australia previously published in this journal by Bambrick and Miller (1994) and Coyle and Coyle (1995) and documents the recruitment of renowned Yuin elder Gaboo Ted Thomas to a Hawaiian-oriented performance troupe in the 1920s.
To Educate in a Diversified Europe
Authors: Osewska Elżbieta
Published: October 2015

One of the main tasks of the EU is to create a European identity. This is a complex matter because of some lasting consequences of many divisions, conflicts and wars of the past. There are many national boundaries and various ethnic and cultural identities, regional interests. This paper refers to a whole range of aspects, which may be identified as crucial for education in a diversified Europe. After presenting the divisions and emerging changes occurring in Europe, the author of this article examines varies parameters / challenges related to the shift in interaction between the levels of society. This dynamic shift introduces a different kind of diversity / plurality and new challenges for education. The fundamental and historical differences can not be easily eliminated; they may deserve to be deepened and analysed. The diversity is a constructive dimension for education in Europe.
Adaptive Religious Education at the Service of Inventiveness: A scientific way of being creative and effective in Religious Education
Authors: Gellel Adrian
Published: October 2015

Student uniqueness demands that the teacher/catechist is inventive not only in the learning methods and teaching techniques employed but also in the way content is structured. Only in this way can the teacher ascertain that his/her students’ requirements are met and, consequently, student learning facilitated. However, teachers’ creativity should not mean haphazard choice of methods and techniques. Teaching is both an art and a science. The limitless nature of creativity should be used judiciously and made to bear fruit through the application of knowledge of educational psychology and instructional design. By using Adaptive Religious Education, the teacher may be guided to use different techniques in a methodical manner in order to ensure and enhance student learning. In particular, thesystematic use of different symbol systems can help teachers to improve student learning. The paper will put forward a number of principles and practical suggestions that may guide teachers in planning R.E. lessons.
L’attualit della dottrina cristologica di Calcedonia
Authors: Królikowski Janusz
Published: October 2015

The Christological doctrine defined during the Chalcedon Council (451) was the point of reference to consolidate the Christian doctrine in the fifth century. It also became the foundation of the evangelizing mission led by the Church in the following centuries. In the context of the new challenges and interpretation a question, whether the Chalcedon doctrine needs to be reinterpreted, arises. This article tries to show the relevance of the Christological dogma which was defined by the Chalcedon Council. The attention is paid to this dogma rooted in the Church Tradition and also to its soteriological and anthropological meaning. The soteriological perspective, which was given the utmost importance during the Chalcedon Council and similarly during other councils held in the first millennium, proves the doctrinal relevance of the dogma and furthermore makes it more meaningful. From the hermeneutic point of view this article presents the need of referring to the principle of theological apophatism in order to interpret the dogma correctly.
Ausrichtung der Forschungen der akademischen Mitarbeiter an der Theologischen Fakultät, Sektion Tarnów
Authors: Stala Józef
Published: October 2015

The 21st century brings new challenges for the society and every human being. Although today’s Europe is in the process of strengthening and enlarging its economic and political union, it seems to suffer from a profound crisis of values. Therefore, it is very important to have a proper perception and understanding of contemporary challenges for education and pedagogy. This might results in going through the effective learning processes, which enable a human being to function properly in his/her private and professional life. For all these reasons, the author of this article shows various aspects of scientific and didactic activities undertaken by the academic staff of the Faculty of Theology, Section in Tarnów, which is an integral part of the Pontifical University of John Paul II in Cracow. A short historical sketch of establishment of the Faculty of Theology, Section in Tarnów enable to embed the academic work of this Faculty in specific realities and conditions.
Wayfaring and Seafaring A Theological Reading of the “Mediterranean Journey”
Authors: Scerri Hector
Published: October 2015

The article dwells upon the theme of the journey in the Mediterranean, the cradle of the three great monotheistic religions. Taking some paradigms for the journey from mythology, history and from Revelation, the physical journey is taken as a metaphor for the pilgrimage of life, an experience marked by maturation and conversion. This spiritual pilgrimage ultimately consists in the individual’s search for the Divine.
Erwartungen an die katholische Schule in einem postmodernen Zeitalter
Authors: Osewska Elżbieta
Published: October 2015

Catholic schools are the subject of many expectations. Yet, the most important sets of expectations are three: parents, the Church and governmental institutions. Parents do not know any more what would be the best preparation for the future of their children, but they expect that Catholic school should prepare their children for their future jobs in the best possible way. The Church concentrates mostly on the religious role of Catholic schools and the governmental education authorities and institutions devote their attention to right attitudes in the civil society. Being a subject of so many, varied expectations, the Catholic school needs to respond constructively to these expectations and show a commitment to the integral and holistic education of every pupil in the postmodern and consumer society.
Call of Lay People to the Mystical Life
Authors: Zyzak Wojciech
Published: October 2015

The subject of this article is the call of lay people to the mystical life. The topic under consideration indicates two poles, around which the main reflection revolves: the mystic and the lay state of life. The call of lay people to mysticism is not just a hypothesis, but a real experience, researched and decribed by theologians. So reflecting on the call to the mystic life of lay people is not so much a matter of ‘whether’, but of ‘how’. In the light of the above, four issues are fundamental: the impossibility to provoke the mystical experience, its dependence on the spirituality of the baptism, the relation of contemplation to action and the relation to the world. It occurs however, that every Christian, together with God’s life of grace bestowed in baptism, receives the basis for the mystical life. Neither an active life in the world, nor work or marriage, hinders the development of this gift.
Fr Luigi Giussani’s Concept of Education - an Outline
Authors: Rynio Alina
Published: October 2015

This outline focuses on the multifarious academic, pedagogical and social activities of Fr Luigi Giussani, Professor of Theology, Italian thinker and scholar renowned for his numerous accomplishments. Due to his exceptional attentiveness, inquisitiveness and courage he has been certainly well-known and highly-regarded not only in university and ecclesiastical but also in the cultural and political spheres of life.The author of this study describes Fr Giussani as an exceptional scholar and educator emphasising the pedagogical aspect of his activities. The study explains his understanding of pedagogy and education. Selected achievements from his biography confirm Fr Giussani to be an exceptional human being, educator and scholar. As an educator, Fr Giussani holds a sober and realistic view of man and his formation: the true value of man, he claims, lies in being rational and free. Complete trust in God and great love for a human person define the most fundamental elements of his approach.The outline also includes a short biographical note and describes popular ways of education, formative events, the educators and educatee’s personality constituents, and the relationship between freedom, conscience, tradition and education.
La preparación al matrimonio según la Exhortación Apostólica Familiaris Consortio. Una reflexión sobre el documento en el 30 aniversario de su elaboración
Authors: Kantor Robert
Published: October 2015

Marriage is an important event in the life of engaged couple as well as the whole community of believers. The preparation for marriage requires that the couple should be introduced into the Catholic ecclesial teaching about the rights and duties which result from contracted marriage. The article presents the issue of preparation for marriage; the stages according to the Apostolic Exhortation Familiaris Consortio. The study includes the following issues: the preparation stage; the need of preparation to marriage; stages and content of the preparation; people responsible for the preparation; permission to celebrate marriage of baptized individuals who are not sufficiently prepared.
Die Transzendenz als bestimmendes Merkmal der Person in der Anthropologie und der Pädagogik Johannes Pauls II.
Authors: Stala Józef
Published: October 2015

John Paul II in his magisterial writings and papal teaching many times referred to the human being, whom he presented in a personal category. At the same time insisted that the major problem of modern civilization is a the wrong anthropology, which denies the spiritual dimension of human being. This wrong approach brings in consequences an instrumental treatment and disgraced human dignity. The human being as a person has the special value that should be affirmed for his own sake, not for any other reason. The human as a being made in the image and likeness of God has a dignity of the person. John Paul II insists that a capacity for relationship with God is of the very essence of human being. God’s invitation to a shared life is a gratuitous, unmerited gift to man who from the beginning was made capax Dei. In these reflections, John Paul II offers many insights about the nature of human identity and dignity. The relationship between human being and God is a guarantee of his dignity. For this reason, anthropology cannot keep only on what is immanent in human being, but applies also to the transcendence. Anthropology disconnected from the transcendent becomes something deeply inhuman. Depriving humanity of its most important dimension also deprives it from its full personal dynamism. Therefore, it appears appropriate to take in this article the issue of transcendence of the person, which is the foundation of anthropology and pedagogy presented by Pope John Paul II. Firstly, the need for portraying the human person as physical and spiritual being will be argued for presented. Then the paper will study the genealogy of humans in communion with the family. In the last part, the marriage as a community of man and woman will be discussed.
Topicality of John Paul II’s Pedagogical Message
Authors: Rynio Alina
Published: October 2015

The purpose of this study is to outline the sources and aspects of the time- surpassing topicality of the Pope’s vision of integral education apparent in his anthropological, permeated with faith, reflection on man. In his vision, the internal perception conditions the integral education of man. The research confirms the thesis that the Pope’s pedagogy assumes an “adequate anthropology” and opens the human heart to the objective order of truth, including truth about Christ as “the centre of the universe and of history” (Redemptor hominis, 1) and to the fundamental truth about man. The Pope’s pedagogy with its anthropological grounding is topical due to the fact that it offers, contemporary times permitting, a complete vision of human education. This vision goes against the culture of lost faith, dehumanisation, nihilism, and existential cynicism, and also against axiological relativism. In this vision, science, technology, art, peace, justice, God, true religion, nature, grace, faith, hope and love are not in complementary distribution, but complement each other. The timeless source of the topical quality of the Pope’s pedagogical message appears to reside in the compatibility and completeness of the human image it provides. It investigates the complex matter of education and the individual story of shaping personalities of outstanding individuals. With due respect and unanticipated amazement, it also provides an outline of the Catholic interpretation of education and the human condition.
A partire da Cristo, Redentore dell’uomo. Sant’Agostino e il Beato Giovanni Paolo II - alcuni punti di riferimento
Authors: Jaśkiewicz Sylwester
Published: October 2015

In Jesus Christ, the human person finds greatness, dignity and worth of humanity. This article reflects on the doctrine of the great African bishop, St. Augustine of Hippo and Pope John Paul II. It discusses the truth about Jesus Christ, the Redeemer of humankind. The concept of redemption as represented by the bishop of Hippo is in essence sacerdotal and sacrificial as it is ultimately expressed by the sacrifice of the Cross. The Cross of Jesus Christ manifests the great and merciful willingness of God towards the fallen human person who is the slave of sin. The triple victory of Christ: over sin, death and Satan, restores the human person to life in the communion with God.
Was John Paul II an Apologist of Christianity?
Authors: Michalik Andrzej
Published: October 2015

The paper tries to answer the question whether John Paul II was an apologist of Christianity. Moving along scholastic methodology, the paper progress along three  stages,  exploring  a  negative  statement  (videtur  quod  non),  justifying a positive assertion (sed contra), to formulate a conclusion (ergo). Through this methodology the paper argues that Pope John Paul II was the defender of Christianity. This methodology allows thorough study of the highlights of the pontificate of this Great Pope and on the basis of counter-points to bring out a more clear answer to the research question.
Der Mensch als Person: Die bestimmende Grundlage für Johannes Paul II. in seinem Bild von der Familie
Authors: Stala Józef
Published: October 2015

Pope John Paul II frequently describes humans in terms of personal being. One could say that this is one of the most fundamental aspects in his teaching. This text analyses the anthropology underlying his papal teaching in the context of the modern world and modern family life. The author emphasizes that the contemporary context reflects a multifaceted  crisis  affecting  humans.  The text explores a core aspect of Pope John Paul II’s teaching in his vision of the family, which is the issue of how to understand the human being as a person. Fundamentally the family is presented as a communion of persons, then a person is shown as the primary determinant in family education.
The Current Situation of Education and Continuing Professional Development of RE Teachers in Poland in the Context of the Social Challenges
Authors: Osewska Elżbieta
Published: October 2015

The author of this article presents Religious Education teachers continuing professional development in Poland in the context of political, social, economic, cultural and educational changes. During the last years, Poland has developed a national strategy for teacher training and introduced many new regulations. The aim of the new legal solutions is to prepare RE teachers as will be competent specialists in theology, accomplished in didactics and pedagogy and capable of caring for – and contributing to – the upbringing of pupils of varying needs; as well as organizers of social activities in class and school, also in effective cooperation with the local parish. Despite the many changes, RE teachers still have very difficult situation in Poland and face many challenges.
Orbiting by Bharati Mukherjee: A Contemporary American Short Story in the English Classroom
Authors: Konopka Ewa
Published: October 2015

The article puts forward arguments why American short stories should be used to teach English as a foreign language. It also describes the method which might help to teach literature in secondary schools. Additionally, it presents the results of the research conducted among students in Lomza, Poland, which aimed at examining the pedagogical potential of applying ethnic American short stories in teaching English as a foreign language. This was done by comparing the literary critical analysis of Orbiting – a short story written by Bharati Mukherjee with its intuitive interpretations by young Polish adults. Finally, the article is supplemented with the passage from the said text as well as lexical and reading comprehension exercises based on its contents, which can be used in the English classroom.
Adaptation of Handbook for Development of Intercultural Competence: the Experiences
Authors: Navaitienė Julita , Račelytė Daiva , Rimkevičienė Violeta
Published: October 2015

The present reflection article discloses the experiences gained during the adaptation of the material for intercultural competence development. The resource book Building Intercultural Competences: A Handbook for professionals in education, social work and health care was selected and its material was adapted to educational context of VET students and teachers. The framework of adaptation of the Handbook is presented in the article. The study was done to investigate the VET students’ and teachers’ needs for intercultural competence development.
Floating License Management - Automation Using Web Technologies
Authors: Doloca Adrian , Ţănculescu Oana
Published: October 2015

This paper examines the use of distributed computing based on web services with application to floating license management. The main goal is to automate the processes pertaining to the management activities and ensure at the same time that the security and flexibility requirements are met. We present the challenges posed by these requirements, propose a design and some implementation aspects using the latest .NET development platform.
O DIREITO À EDUCAÇÃO E A NOVA SEGREGAÇÃO SOCIAL E RACIAL - TEMPOS INSATISFATÓRIOS?
Authors: Arroyo Miguel G.
Published: October 2015

RESUMO: Discutem-se questões urgentes que afetam o direito à educação. O texto defende que estamos diante de uma nova segregação social e racial. São tempos que se desdobram em uma tensão entre afirmação e negação dos direitos humanos e redução do direito à educação ao mínimo, que se expressa na presença afirmativa dos coletivos sociais e nas medidas de controle e repressão às suas lutas. Como essas tensões sociais e políticas afetam o direito à educação? Defende-se que a luta pelo direito à educação não poderá se desvincular da luta contra a criminalização moral dos adolescentes e jovens populares como justificativa para a sua segregação social e racial tão em voga atualmente. No contexto brasileiro contemporâneo, a luta por justiça educacional está vinculada à luta e à denúncia da segregação social e racial de nossas crianças e jovens.
La cuantificación de la población esclava en la Andalucía moderna. Una revisión metodológica
Authors: Pérez García Rafael M. , Fernández Chaves Manuel F.
Published: October 2015

RESUMONeste artigo os autores tratam de revisitar a historiografía produzida sobre a escravidão em Andaluzia durante a Idade Moderna, a qual tentou de quantificar o número de escravos na região. As metodologias e os diferentes tipos de fontes históricas empregadas nesta quantificação histórica são objecto de revisão metodológica, nomeadamente o uso das fontes notariáis e os registros de batismo. Ambas tem sido fontes muito importantes para os historiadores que pesquisaram a escravidão na Andaluzia moderna. Utiliza-se uma perspectiva comparada dos resultados obtidos até agora acrescentados com nova documentação primaria, procurando assim oferecer considerações de carácter metodológico para poder estudar estes problemas históricos com uma metodología científica extrapolável a outras regiões e ámbitos cronológicos.
Uma análise da prevenção do câncer de mama no Brasil
Authors: Rodrigues Juliana Dantas , Cruz Mércia Santos , Paixão Adriano Nascimento
Published: October 2015

ResumoA presente pesquisa se propõe a estudar as inter-relações entre a prevenção do câncer de mama e os fatores socioeconômicos, demográficos, comportamentais, regionais e de saúde na determinação da frequência temporal à busca por prevenção via realização de mamografias e exames de mama no Brasil. A partir das informações do suplemento de saúde da Pesquisa Nacional por Amostra de Domicílios, de 2008, foi construída uma amostra que contempla apenas mulheres com mais de 40 anos de idade. Para o atendimento do objetivo proposto, faz-se uso da estimação do modelo logit, ordenado de chances proporcionais parciais, que indicaram como principais resultados: i) melhores condições socioeconômicas, residir nas regiões mais desenvolvidas do país, uma composição familiar que inclua filhos, apresentar uma boa autoavaliação da própria saúde e já ter sido diagnosticada com algum tipo de câncer, desenham o perfil da mulher que mais se previne contra o câncer de mama, tanto em relação à procura por mamografia, como a uma maior demanda por exame de mama realizado por médico ou enfermeiro e; ii) os resultados apontam ainda para o fato de que grande parte das entrevistadas realizaram os exames em questão há pelo menos um ano, ou nunca passaram por tais procedimentos.
Clinical variables associated with depression in patients with type 2 diabetes
Authors: Ferreira Mari Cassol , Piaia Camila , Cadore Ana Carolina , Antoniolli Marinez Amabile , Gamborgi Geni Portela , Oliveira Patrícia Pereira de
Published: October 2015

SummaryBackground:the aim of the study was to evaluate the relationship between type 2 diabetes (T2DM), depression and depressive symptoms and their clinical impact on T2DM.Methods:the authors evaluated 214 outpatients, 105 with diabetes (T2DM group) and 109 non-diabetics (control group), with ages ranging between 50 and 75 years (T2DM group 65.1 ± 5.6 years, control group 63.4 ± 5.8 years). Use of antidepressant treatment or score ≥ 16 on the Beck depression inventory (BDI) was considered depression. Complications of diabetes and total symptom score (TSS) for peripheral neuropathy were reported by patients.Results:diabetes group had a higher frequency of depression (35.2%) compared to controls (21.1%) (p=0,021), with 2.4 times increased risk of depression. The presence of depressive symptoms was also higher in T2DM group (mean BDI 9.5 ± 8.8 versus 6.9 ± 6.2; p=0.039). Symptoms of diabetic neuropathy were higher in depressed subjects. The metabolic control and presence of complications in T2DM group were not associated with depression.Conclusion:T2DM led to an increased risk of depression, but this did not influence the metabolic control or the presence of other complications.
Produção Científica sobre Família e Comunidade na Base de Dados PePSIC (2002/2012)
Authors: Santeiro Tales Vilela , Souza Tatiana Machiavelli Carmo , Scorsolini-Comin Fabio , Santeiro Fabíola Ribeiro de Moraes
Published: October 2015

Esta revisão sistemática de literatura teve por objetivo mapear as variáveis relacionadas à produção científica sobre família e comunidade, indexada na base de dados Periódicos Eletrônicos em Psicologia (PePSIC). A busca de informações foi realizada por meio dos vocábulos "família" e "comunidade" e contemplou artigos completos, publicados entre 2002 e 2012 (n = 44). Foi realizado tratamento quantitativo e qualitativo na amostra. No geral, os estudos foram produzidos no sudeste brasileiro, em instituições privadas de ensino superior, com relativo destaque para investigações empíricas e relatos de experiência desenvolvidos por mulheres, e na modalidade de autoria múltipla. A produção foi divulgada em periódicos nacionais, que seguem critérios editoriais reconhecidos pela comunidade acadêmica (Qualis/CAPES). Temáticas sobre infância e adolescência foram priorizadas nos trabalhos, com diversidade de enfoques teóricos da Psicologia. As intervenções psicológicas relatadas abarcaram propostas terapêuticas e não terapêuticas, individuais e grupais, e transcorreram em ambientes institucionais. Análises comparativas, com amostras obtidas em outras fontes de informação, são desejáveis e encontram-se em andamento.