bluuebunny/crossref_metadata_2025 huggingface dataset:
Hierarchical TiO2 spheres as highly efficient polysulfide host for lithium-sulfur batteries
Authors: Yang Zhi-Zheng , Wang Hui-Yuan , Lu Lun , Wang Cheng , Zhong Xiao-Bin , Wang Jin-Guo , Jiang Qi-Chuan
Published: March 2016

Hierarchical TiO2 micron spheres assembled by nano-plates were prepared through a facile hydrothermal route. Chemical tuning of the TiO2 through hydrogen reduction (H-TiO2) is shown to increase oxygen-vacancy density and thereby modifies the electronic properties. H-TiO2 spheres with a polar surface serve as the surface-bound intermediates for strong polysulfides binding. Under the restricting and recapturing effect, the sulfur cathode could deliver a high reversible capacity of 928.1 mA h g−1 after 50 charge-discharge cycles at a current density of 200 mA g−1. The H-TiO2 additive developed here is practical for restricting and recapturing the polysulfide from the electrolyte.
Evolution of conditional cooperation under multilevel selection
Authors: Zhang Huanren , Perc Matjaž
Published: March 2016

We study the emergence of conditional cooperation in the presence of both intra-group and inter-group selection. Individuals play public goods games within their groups using conditional strategies, which are represented as piecewise linear response functions. Accordingly, groups engage in conflicts with a certain probability. In contrast to previous studies, we consider continuous contribution levels and a rich set of conditional strategies, allowing for a wide range of possible interactions between strategies. We find that the existence of conditional strategies enables the stabilization of cooperation even under strong intra-group selection. The strategy that eventually dominates in the population has two key properties: (i) It is unexploitable with strong intra-group selection; (ii) It can achieve full contribution to outperform other strategies in the inter-group selection. The success of this strategy is robust to initial conditions as well as changes to important parameters. We also investigate the influence of different factors on cooperation levels, including group conflicts, group size and migration rate. Their effect on cooperation can be attributed to and explained by their influence on the relative strength of intra-group and inter-group selection.
Secreted APE1/Ref-1 inhibits TNF-α-stimulated endothelial inflammation via thiol-disulfide exchange in TNF receptor
Authors: Park Myoung Soo , Choi Sunga , Lee Yu Ran , Joo Hee Kyoung , Kang Gun , Kim Cuk-Seong , Kim Soo Jin , Lee Sang Do , Jeon Byeong Hwa
Published: March 2016

Apurinic apyrimidinic endonuclease 1/Redox factor-1 (APE1/Ref-1) is a multifunctional protein with redox activity and is proved to be secreted from stimulated cells. The aim of this study was to evaluate the functions of extracellular APE1/Ref-1 with respect to leading anti-inflammatory signaling in TNF-α-stimulated endothelial cells in response to acetylation. Treatment of TNF-α-stimulated endothelial cells with an inhibitor of deacetylase that causes intracellular acetylation, considerably suppressed vascular cell adhesion molecule-1 (VCAM-1). During TSA-mediated acetylation in culture, a time-dependent increase in secreted APE1/Ref-1 was confirmed. The acetyl moiety of acetylated-APE1/Ref-1 was rapidly removed based on the removal kinetics. Additionally, recombinant human (rh) APE1/Ref-1 with reducing activity induced a conformational change in rh TNF-α receptor 1 (TNFR1) by thiol-disulfide exchange. Following treatment with the neutralizing anti-APE1/Ref-1 antibody, inflammatory signals via the binding of TNF-α to TNFR1 were remarkably recovered, leading to up-regulation of reactive oxygen species generation and VCAM-1, in accordance with the activation of p66shc and p38 MAPK. These results strongly indicate that anti-inflammatory effects in TNF-α-stimulated endothelial cells by acetylation are tightly linked to secreted APE1/Ref-1, which inhibits TNF-α binding to TNFR1 by reductive conformational change, with suggestion as an endogenous inhibitor of vascular inflammation.
Scaling-down antibody radiolabeling reactions with zirconium-89
Authors: Knight James C. , Paisey Stephen J. , Dabkowski Adam M. , Marculescu Cristina , Williams Anwen S. , Marshall Christopher , Cornelissen Bart
Published: March 2016

A 89Zr-radiolabeling procedure that provides high radiochemical yields at the microgram scale has been reported.
Advances in identification and validation of protein targets of natural products without chemical modification
Authors: Chang J. , Kim Y. , Kwon H. J.
Published: March 2016

This review focuses on and reports case studies of the latest advances in target protein identification methods for label-free natural products. The integration of newly developed technologies will provide new insights and highlight the value of natural products for use as biological probes and new drug candidates.
Chitin and carbon nanotube composites as biocompatible scaffolds for neuron growth
Authors: Singh Nandita , Chen Jinhu , Koziol Krzysztof K. , Hallam Keith R. , Janas Dawid , Patil Avinash J. , Strachan Ally , G. Hanley Jonathan , Rahatekar Sameer S.
Published: March 2016

Preparation of biocompatible and electrically-conducting chitin nanotube composite scaffold for potential use in implantable electrode for stimulation and repair of neurons.
Defect segregation and optical emission in ZnO nano- and microwires
Authors: Ruane W. T. , Johansen K. M. , Leedy K. D. , Look D. C. , von Wenckstern H. , Grundmann M. , Farlow G. C. , Brillson L. J.
Published: March 2016

The spatial distribution of defect related deep band emission in zinc oxide nano- and microwires using depth resolved cathodoluminescence spectroscopy.
Precision improvement in dark-field microscopy imaging by using gold nanoparticles as an internal reference: a combined theoretical and experimental study
Authors: Ma Jun , Liu Yue , Gao Peng Fei , Zou Hong Yan , Huang Cheng Zhi
Published: March 2016

The internal reference (IR) was introduced to dark-field microscopic imaging (iDFM) technique to reduce the large unavoidable measurement errors, and improved precision of the acquired signals has been obtained.
Direct polymerization of novel functional sulfonated poly(arylene ether ketone sulfone)/sulfonated poly(vinyl alcohol) with high selectivity for fuel cells
Authors: Xu Jingmei , Wang Zhe , Zhang Huixuan , Ni Hongzhe , Luo Xueyan , Liu Bingxin
Published: March 2016

The acid–base pairs (–SO3H⋯H2N–) formed between –SO3H and –NH2 can promote protons transport.
Improvement of n-type conductivity in hexagonal boron nitride monolayers by doping, strain and adsorption
Authors: Ding Yi-min , Shi Jun-jie , Zhang Min , Jiang Xin-he , Zhong Hong-xia , Huang Pu , Wu Meng , Cao Xiong
Published: March 2016

The n-type conductivity of h-BN monolayers is improved significantly via doping, applying strain and alkali-metal atom adsorption.
Nanoparticle coupling effect allows enhanced localized field on Au bowl-like pore arrays
Authors: Yao Min , Zhou Fei , Shi Jianping , Wang Jingjing , Duan Guotao
Published: March 2016

A simple, effective, and productive method to fabricate an ordered Au pore array of Au/Ag nanoparticles is proposed. The ordered Au pore array with Au/Ag nanoparticles exhibits a strong SERS performance for R6G as the probe molecules.
Variable surface transport modalities on functionalized nylon films revealed with single molecule spectroscopy
Authors: Tauzin Lawrence J. , Shen Hao , Moringo Nicholas A. , Roddy Margaret H. , Bothof Cathy A. , Griesgraber George W. , McNulty Amy K. , Rasmussen Jerald K. , Landes Christy F.
Published: March 2016

Functionalization of separation membranes with ion-exchange ligands allows control of the surface mobility of protein molecules facilitating optimized membrane design.
Synthesis and assessment of novel anticorrosive polyurethane coatings containing an amine-functionalized nanoclay additive prepared by the cathodic electrophoretic deposition method
Authors: Moradi Maryam , Yeganeh Hamid , Pazokifard Shahla
Published: March 2016

Cathodic electrophoretic deposition (CEPD) was utilized to cover a mild steel cathode in an aqueous solution consisting of a newly synthesized two-component one-pack waterborne polyurethane resin.
Fibrous AuPt bimetallic nanocatalyst with enhanced catalytic performance
Authors: Rahmi Elvy , Umar Akrajas Ali , Abd Rahman Mohd Yusri , Salleh Muhamad Mat , Oyama Munetaka
Published: March 2016

Enhanced-catalytic hydrogenation of acetone is observed over AuPt fibrous bimetallic nanoparticles. High d-electron instability in Pt nanocrystal upon bimetallisation is the key factor for high-catalytic performance.
The significance of different heating methods on the synthesis of CdS nanocrystals
Authors: Jin Huile , Chen Liyun , Liu Aili , Guan Lei , Yin Dewu , Lin Pengsheng , Wang Shun , Jiang Weizhong
Published: March 2016

Both microwave-assisted and oil-bath heating approaches were investigated for fabraction of CdS nanocrystals, and the photocatalysis properties of CdS were explored.
Diastereoselective synthesis of vicinal tertiary and N-substituted quaternary stereogenic centers by catalytic hydroalkylation of dienes
Authors: Goldfogel Matthew J. , Meek Simon J.
Published: March 2016

An efficient and diastereoselective (CDC)–Rh-catalyzed hydroalkylation of dienes with 1,3-oxazol-5(4H)-ones is reported.
Controlling the ion release from mixed alkali bioactive glasses by varying modifier ionic radii and molar volume
Authors: Brückner Raika , Tylkowski Maxi , Hupa Leena , Brauer Delia S.
Published: March 2016

Modifier ionic radius controls ion release from bioactive phospho-silicate glassesviasilicate network compactness.
On the impact of isomer structure and packing disorder in thienoacene organic semiconductors
Authors: Thorley Karl J. , Risko Chad
Published: March 2016

Using benzodithiophene as a model compound, the concept of the disordermer is introduced to discuss how intermolecular isomerism in the solid state can result in a wide range of available molecular packing arrangements that in turn influence the magnitude of the electronic coupling, a key parameter of importance to the performance of organic semiconductors.
Fabrication and characterization of structurally colored pigments based on carbon-modified ZnS nanospheres
Authors: Wang Fen , Zhang Xin , Lin Ying , Wang Lei , Qin Yi , Zhu Jianfeng
Published: March 2016

Chemical pigments are widely used in various industries.
Real-time quantitative nicking endonuclease-mediated isothermal amplification with small molecular beacons
Authors: Xu Wentao , Wang Chenguang , Zhu Pengyu , Guo Tianxiao , Xu Yuancong , Huang Kunlun , Luo Yunbo
Published: March 2016

This nicking endonuclease-mediated isothermal amplification with small molecular beacons (SMB-NEMA) method allows the simple, specific and sensitive assessment of isothermal DNA quantification.
Affinity-based thermoresponsive precipitation of proteins modified with polymer-binding peptides
Authors: Suzuki Seigo , Sawada Toshiki , Ishizone Takashi , Serizawa Takeshi
Published: March 2016

A model protein (i.e., human serum albumin) chemically modified with a 12-mer peptide with an affinity for the meso diad sequence of poly(N-isopropylacrylamide) (PNIPAM) was successfully precipitated with PNIPAM above the lower critical solution temperature of PNIPAM.
Catalytic conversion of methanol/ethanol to isobutanol – a highly selective route to an advanced biofuel
Authors: Wingad Richard L. , Bergström Emilie J. E. , Everett Matthew , Pellow Katy J. , Wass Duncan F.
Published: March 2016

Catalysts based on ruthenium diphosphine complexes convert methanol/ethanol mixtures to the advanced biofuel isobutanol, with extremely high selectivity (>99%) at good (>75%) conversion via a Guerbet-type mechanism.
Fibrous polyaniline@manganese oxide nanocomposites as supercapacitor electrode materials and cathode catalysts for improved power production in microbial fuel cells
Authors: Ansari Sajid Ali , Parveen Nazish , Han Thi Hiep , Ansari Mohammad Omaish , Cho Moo Hwan
Published: March 2016

Fibrous Pani–MnO2 nanocomposites were prepared using a one-step and scalable in situ chemical oxidative polymerization method.
Synthesis and characterization of fibrous silica ZSM-5 for cumene hydrocracking
Authors: Firmansyah M. L. , Jalil A. A. , Triwahyono S. , Hamdan H. , Salleh M. M. , Ahmad W. F. W. , Kadja G. T. M.
Published: March 2016

Fibrous silica ZSM-5 (FZSM-5) with a novel dendrimeric morphology was synthesized using a CTAB-based microemulsion system. The dendrimers increased the active site accessibility and enhanced the catalytic activity for large molecule hydrocracking and ethylbenzene dehydrogenation.
Unusual penta- and hexanuclear Ni(ii)-based silsesquioxane polynuclear complexes
Authors: Bilyachenko Alexey N. , Yalymov Alexey I. , Korlyukov Alexander A. , Long Jérôme , Larionova Joulia , Guari Yannick , Vologzhanina Anna V. , Es'kova Marina A. , Shubina Elena S. , Levitsky Mikhail M.
Published: March 2016

Cage-like Ni(ii)-silsesquioxanes demonstrate the presence of a slow relaxation of the magnetization, induced by spin glass-like behavior.
Unravelling the complex nanostructure of La0.5−xLi0.5−xSr2xTiO3 Li ionic conductors
Authors: García-González Ester , Urones-Garrote Esteban , Várez Alejandro , Sanz Jesús
Published: March 2016

The intricate nanostructure of La0.5−xLi0.5−xSr2xTiO3 Li-ion conductors has been elucidated. Advanced transmission electron microscopy has allowed investigation where average structure models cannot account for the changeable local atomic arrangements detected.
Inulin and fructooligosaccharide affect in vitro calcium uptake and absorption from calcium-enriched gluten-free bread
Authors: Krupa-Kozak U. , Świątecka D. , Bączek N. , Brzóska M. M.
Published: March 2016

Inulin-type fructans enhance calcium uptake from calcium-enriched gluten-free bread and stimulate the applied intestinal bacteria to the intensive organic acids synthesis.
Hollow mesoporous raspberry-like colloids with removable caps as photoresponsive nanocontainers
Authors: Hu Chi , West Kevin R. , Scherman Oren A.
Published: March 2016

The fabrication, characterisation and controlled cargo release of hollow mesoporous raspberry-like colloids (HMRCs), which are assembled by utilising host–guest complexation of cucurbit[8]uril (CB[8]) are described.
Silsesquioxane-cored star amphiphilic polymer as an efficient dispersant for multi-walled carbon nanotubes
Authors: Gao Shuxi , Yu Zhiwei , Xu Kai , Peng Jun , Xing Yuxiu , Ren Yuanyuan , Chen Mingcai
Published: March 2016

One octopus-shaped amphiphilic polymer was used to functionalize MWNTs for the first time.
Soft-template synthesis of hydrophilic metallic zirconia nanoparticle-incorporated ordered mesoporous carbon composite and its application in phosphopeptide enrichment
Authors: Zhang Lei , Xiong Zhichao , Chen Yajing , Peng Li , Yu Bohao , Gao Xiaodi , Zhang Runsheng , Zhang Lingyi , Zhang Weibing
Published: March 2016

The novel metallic zirconia incorporated OMC as a metal oxide affinity chromatography material was successfully applied to detection and identification the low-abundance phosphopeptides from non-fat milk.
Understanding the role of phosphate in the photoelectrochemical performance of cobalt-phosphate/hematite electrode systems
Authors: Wang TsingHai , Hung Hsin-Ting , Cheng Yu-Rong , Huang Mao-Chia , Hsieh Yi-Kong , Wang Chu-Fang
Published: March 2016

The complex of cobalt-phosphate (CoPi) is known to be an efficient catalyst that can greatly enhance the photoelectrochemical (PEC) performance of hematite electrodes.
The strategy of two-scale interface enrichment for constructing ultrasensitive SERS substrates based on the coffee ring effect of AgNP@β-CD
Authors: Pan Xiaoyu , Dong Jian , Li Yan , Sun Xiang , Yuan Chunwei , Qian Weiping
Published: March 2016

Herein we introduced a Raman technique for the detection of aromatic compounds. The combination of the pre-concentration of β-CD and the SERS effect of the coffee-ring enhanced the detection ability of SERS to aromatic compounds.
Gram-grade Cr(vi) adsorption on magnetite/carbon hybrid architectures
Authors: Sun Shuangshuang , Ma Ji , Liu Wei , Chen Kezheng
Published: March 2016

The maximum Cr(vi) adsorption capacities on our as-synthesized Fe3O4@C architectures were found to be ca. 1100 mg g−1.
Electrochemical deposition of manganese oxide–phosphate–reduced graphene oxide composite and electrocatalysis of the oxygen evolution reaction
Authors: Irshad Ahamed , Munichandraiah Nookala
Published: March 2016

The MnOx–Pi–rGO OER catalyst is prepared by the simultaneous electrochemical reduction of MnO4−ions and GO in a neutral phosphate electrolyte.
Mechanical properties of zigzag-shaped carbon nanotubes: the roles of the geometric parameters
Authors: Liu Lizhao
Published: March 2016

Empirical formulae were fitted to describe relationships between the intrinsic strength/Young's modulus and curvature of the Z-CNTs.
Deciphering the in vitro homo and hetero oligomerization characteristics of CXCL1/CXCL2 chemokines
Authors: Gulati Khushboo , Poluri Krishna Mohan
Published: March 2016

Murine GRO chemokines CXCL1(mKC)/CXCL2(MIP2) forms heterodimers and thus adding another layer of regulatory mechanism for leukocyte trafficking during infection/inflammation.
Anionic metal–organic framework hybrids: functionalization with lanthanide ions or cationic dyes and fluorescence sensing of small molecules
Authors: Shen Xiang , Yan Bing
Published: March 2016

An anionic metal–organic framework, [HDMA]2[Zn2(BDC)3(DMA)]·6DMF is modified by lanthanides and they exhibit selective adsorption ability to cationic dyes. RhB@1 has a rapidest response and realizes sensing acetone and aniline.
Mass spectrometry based chemical imaging of foods
Authors: Kadam Shekhar U. , Misra N. N. , Zaima Nobuhiro
Published: March 2016

Chemical imaging based on mass spectrometry is an emerging technology which has opened opportunities for fundamental research in food science.
Carbon-based dots co-doped with nitrogen and sulfur for Cr(vi) sensing and bioimaging
Authors: Liu Yang , Gong Xiaojuan , Gao Yifang , Song Shengmei , Wu Xin , Shuang Shaomin , Dong Chuan
Published: March 2016

Less toxic elements nitrogen and sulfur co-doped carbon-based dots (NSCDs) have been prepared by microwave-assisted pyrolysis of citric acid and N-acetyl-l-cysteine as the carbon and N,S-dopant, respectively.
Facile synthesis of Gd(iii) metallosurfactant-functionalized carbon nanodots with high relaxivity as bimodal imaging probes
Authors: Zhu Qin , Pan Fei , Tian Yu , Tang Weijun , Yuan Yuan , Hu Aiguo
Published: March 2016

Fluorescence and magnetic resonance (MR) dual-modal imaging contrast agents were prepared by the ionic self-assembly of carbon nanodots (CDs) and gadolinium(iii)-containing metallosurfactants (MS).
Hofmeister effect on thermo-responsive poly(propylene oxide) in H2O and D2O
Authors: Moghaddam Saeed Zajforoushan , Thormann Esben
Published: March 2016

The Hofmeister effect of NaSCN, NaCl and NaF on poly(propylene oxide) solutions in H2O and D2O.
Mycobacterium tuberculosis histidinol dehydrogenase: biochemical characterization and inhibition studies
Authors: Lunardi Juleane , Borges Martinelli Leonardo Kras , Raupp Alessandra Silva , Sacconi Nunes José Eduardo , Rostirolla Diana Carolina , Saraiva Macedo Timmers Luís Fernando , Villela Anne Drumond , Pissinate Kenia , Limberger Jones , Norberto de Souza Osmar , Basso Luiz Augusto , Santos Diógenes Santiago , Machado Pablo
Published: March 2016

We describe a series of biochemical studies on recombinantMycobacterium tuberculosisHisD (MtHisD) and the synthesis of a series of compounds which are, to the best of our knowledge, the first inhibitors ofMtHisD activity reported in the literature.
Co(acac)2/O2-catalyzed oxidative isocyanide insertion with 2-vinylanilines: efficient synthesis of 2-aminoquinolines
Authors: Xu Pei , Zhu Tong-Hao , Wei Tian-Qi , Wang Shun-Yi , Ji Shun-Jun
Published: March 2016

A series of 2-aminoquinolines were afforded by Co(acac)2 catalyzed isocyanide insertion with 2-vinylanilines under an O2 atmosphere.
Radar-like MoS2 nanoparticles as a highly efficient 808 nm laser-induced photothermal agent for cancer therapy
Authors: Huang Zichen , Qi Yafei , Yu Dexin , Zhan Jinhua
Published: March 2016

Radar-like MoS2 nanoparticles were demonstrated and used as highly efficient photothermal therapy for cancer in vitro and in vivo.
Aggregation kinetics and cluster structure of amino-PEG covered gold nanoparticles
Authors: Zámbó D. , Pothorszky Sz. , Brougham D. F. , Deák A.
Published: March 2016

Perturbation induced directed self-assembly of amino PEGylated gold nanoparticles: kinetics of aggregation and cluster structure.
Introduction of a novel nanosized N-sulfonated Brönsted acidic catalyst for the promotion of the synthesis of polyhydroquinoline derivatives via Hantzsch condensation under solvent-free conditions
Authors: Goli-Jolodar Omid , Shirini Farhad , Seddighi Mohadeseh
Published: March 2016

In this research NS-C4(DABCO-SO3H)2)·4Cl as a new nano sizedN-sulfonic acid was prepared and characterized using different types of methods including FT-IR,1H NMR,13C NMR, mass, XRD, TGA, SEM and AFM analysis.
Understanding the formation of aligned, linear arrays of Ag nanoparticles
Authors: Walliser Roché M. , Tóth Rita , Lagzi István , Mathys Daniel , Marot Laurent , Braun Artur , Housecroft Catherine E. , Constable Edwin C.
Published: March 2016

A self-assembly process, the Liesegang phenomenon, was applied to align silver nanoparticles in highly periodic linear arrays and two alternative mechanisms were proposed to explain the process.
Bio-inspired writable multifunctional recycled paper with outer and inner uniform superhydrophobicity
Authors: Si Yifan , Guo Zhiguang
Published: March 2016

One kind of multifunctional superhydrophobic recycled paper from the secondary use of waste paper has been prepared successfully with wonderful self-cleaning, anti-fouling and oil absorption abilities.
A nuclear targeted dual-photosensitizer for drug-resistant cancer therapy with NIR activated multiple ROS
Authors: Yu Zhengze , Pan Wei , Li Na , Tang Bo
Published: March 2016

A nuclear targeted dual-photosensitizer was developed for photodynamic therapy against multidrug resistant cancer. Multiple reactive oxygen species (ROS) could be generated in the nucleus to directly break DNA double strands with a single 980 nm NIR laser irradiation, regardless of drug resistance.
Towards high potential and ultra long-life cathodes for sodium ion batteries: freestanding 3D hybrid foams of Na7V4(P2O7)4(PO4) and Na7V3(P2O7)4@biomass-derived porous carbon
Authors: Li Qiufeng , Lin Bo , Zhang Sen , Deng Chao
Published: March 2016

Freestanding 3D hybrid foam is a widely applicable, low cost and highly efficient architecture to construct high potential and ultra long life cathodes for sodium ion batteries.
Design and synthesis of energetic materials towards high density and positive oxygen balance by N-dinitromethyl functionalization of nitroazoles
Authors: Zhao X. X. , Li S. H. , Wang Y. , Li Y. C. , Zhao F. Q. , Pang S. P.
Published: March 2016

The top of the pyramid of tetrazole-based CHNO energetic materials for density and OB: N-dinitromethyl functionalization is a new N-functionalized strategy for the synthesis of highly dense and oxygen-rich energetic materials.
Enzyme-conjugated ZIF-8 particles as efficient and stable Pickering interfacial biocatalysts for biphasic biocatalysis
Authors: Shi Jiafu , Wang Xiaoli , Zhang Shaohua , Tang Lei , Jiang Zhongyi
Published: March 2016

Enzyme-based biphasic catalytic reactions were successfully accomplished by utilizing CRL-conjugated ZIF-8 particles as robust Pickering interfacial biocatalysts.
A photostable AIEgen for nucleolus and mitochondria imaging with organelle-specific emission
Authors: Yu Chris Y. Y. , Zhang Weijie , Kwok Ryan T. K. , Leung Chris W. T. , Lam Jacky W. Y. , Tang Ben Zhong
Published: March 2016

A dual-color organelle-specific probe with the AIE feature for mitochondria and nucleolus is developed. Due to the different interactions with mitochondrial membrane and nucleic acids, distinct emission colors from mitochondria and nucleolus are observed under a fluorescence microscope.
Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling
Authors: Chowdhury Md. Kamrul H. , Wu Lindsay E. , Coleman James L.J. , Smith Nicola J. , Morris Margaret J. , Shepherd Peter R. , Smith Greg C.
Published: March 2016

Recently, it has been found that glucagon is able to activate the β-catenin signalling pathway leading to increased cyclin D1 and c-Myc expression in liver. Therefore the main aim of the present study is to determine whether the effect of glucagon activating β-catenin signalling leading to increased target gene expression is mediated through cAMP activation of PKA (protein kinase A). Primary rat hepatocytes were incubated with insulin, glucagon or adrenaline (epinephrine) and a range of inhibitors of PI3K (phosphoinositide 3-kinase), Wnt, mitochondrial uncoupler (niclosamide) or PKA inhibitors to dissect out the pathway leading to increased Ser552 phosphorylation on β-catenin following glucagon exposure. In primary rat hepatocytes, we found that short exposure to glucagon or adrenaline caused a rapid increase in Ser552 phosphorylation on β-catenin that leads to increased cyclin D1 and c-Myc expression. A range of PI3K and Wnt inhibitors were unable to block the effect of glucagon phosphorylating β-catenin. Interestingly, both niclosamide and the PKA inhibitor H89 blocked the glucagon effect on β-catenin signalling, leading to a reduction in target gene expression. Likewise, niclosamide inhibited cAMP levels and the direct addition of db-cAMP (dibutyryl-cAMP sodium salt) also resulted in Ser552 phosphorylation of β-catenin. We have identified a new pathway via glucagon signalling that leads to increased β-catenin activity that can be reversed with the antihelminthic drug niclosamide, which has recently shown promise as a potential treatment of T2D (Type 2 diabetes). This novel finding could be useful in liver cancer treatment, particularly in the context of T2D with increased β-catenin activity.
Exploring the structure of glutamate racemase from Mycobacterium tuberculosis as a template for anti-mycobacterial drug discovery
Authors: Poen Sinothai , Nakatani Yoshio , Opel-Reading Helen K. , Lassé Moritz , Dobson Renwick C.J. , Krause Kurt L.
Published: March 2016

Glutamate racemase (MurI) is responsible for providing D-glutamate for peptidoglycan biosynthesis in bacteria and has been a favoured target in pharmaceutical drug design efforts. It has recently been proven to be essential in Mycobacterium tuberculosis, the causative organism of tuberculosis, a disease for which new medications are urgently needed. In the present study, we have determined the protein crystal structures of MurI from both M. tuberculosis and Mycobacterium smegmatis in complex with D-glutamate to 2.3 Å and 1.8 Å resolution respectively. These structures are conserved, but reveal differences in their active site architecture compared with that of other MurI structures. Furthermore, compounds designed to target other glutamate racemases have been screened but do not inhibit mycobacterial MurI, suggesting that a new drug design effort will be needed to develop inhibitors. A new type of MurI dimer arrangement has been observed in both structures, and this arrangement becomes the third biological dimer geometry for MurI found to date. The mycobacterial MurI dimer is tightly associated, with a KD in the nanomolar range. The enzyme binds D- and L-glutamate specifically, but is inactive in solution unless the dimer interface is mutated. We created triple mutants of this interface in the M. smegmatis glutamate racemase (D26R/R105A/G194R or E) that have appreciable activity (kcat=0.056–0.160 min−1 and KM=0.26–0.51 mM) and can be utilized to screen proposed antimicrobial candidates for inhibition.
Computationally efficient real‐time interpolation algorithm for non‐uniform sampled biosignals
Authors: Guven Onur , Eftekhar Amir , Kindt Wilko , Constandinou Timothy G.
Published: March 2016

This Letter presents a novel, computationally efficient interpolation method that has been optimised for use in electrocardiogram baseline drift removal. In the authors’ previous Letter three isoelectric baseline points per heartbeat are detected, and here utilised as interpolation points. As an extension from linear interpolation, their algorithm segments the interpolation interval and utilises different piecewise linear equations. Thus, the algorithm produces a linear curvature that is computationally efficient while interpolating non‐uniform samples. The proposed algorithm is tested using sinusoids with different fundamental frequencies from 0.05 to 0.7 Hz and also validated with real baseline wander data acquired from the Massachusetts Institute of Technology University and Boston's Beth Israel Hospital (MIT‐BIH) Noise Stress Database. The synthetic data results show an root mean square (RMS) error of 0.9 μV (mean), 0.63 μV (median) and 0.6 μV (standard deviation) per heartbeat on a 1 mVp–p 0.1 Hz sinusoid. On real data, they obtain an RMS error of 10.9 μV (mean), 8.5 μV (median) and 9.0 μV (standard deviation) per heartbeat. Cubic spline interpolation and linear interpolation on the other hand shows 10.7 μV, 11.6 μV (mean), 7.8 μV, 8.9 μV (median) and 9.8 μV, 9.3 μV (standard deviation) per heartbeat.
Individual Persuasive Eco‐travel Technology, a mobile persuasive application for implementing voluntary travel behaviour change programmes
Authors: Sanjust di Teulada Benedetta , Meloni Italo
Published: March 2016

This study presents a voluntary travel behaviour change (VTBC) programme that involves the use of a technology platform. The platform has been developed both for enhancing the efficacy of the implementation and for highlighting the contribution that technology itself can provide in persuasion strategies. It can be applied in the VTBC implementation for encouraging individuals to reduce car use, mitigating global greenhouse gas emissions. In particular, the proposed platform is designed to automate phases and activities of a VTBC programme, with a view to extending it to the large scale, reducing the resource commitment. Indeed, technology could contribute to facilitating the operational and functional aspects, through the implementation of automated VTBC programmes, broadening their applicability while maintaining effectiveness. Furthermore, technology can be persuasive in changing behaviour.
Study on phase velocity tapered microstrip angular log‐periodic meander line travelling wave tube
Authors: Li Xinyi , Xu Youkun , Wang Shaomeng , Wang Zhanliang , Shi Xianbao , Duan Zhaoyun , Wei Yanyu , Feng Jinjun , Gong Yubin
Published: March 2016

To improve the efficiency of beam‐wave interaction and the gain of the microstrip angular log‐periodic meander‐line (MALPML) travelling wave tube (TWT), a modified phase velocity tapered MALPML (PVT‐MALPML) with 45° chamfer is proposed in this study. Compared with MALPML slow wave structure (SWS), the PVT‐MALPML SWS has better transmission characteristics. Meanwhile, the beam‐wave interaction simulation results show that a higher gain and electron efficiency can be produced by the PVT‐MALPML TWT. By using the novel PVT‐MALPML SWS, the properties of the radial TWT is further improved to meet the requirements of electronic system to TWTs.
Frequency reconfigurable self‐adapting conformal array for changing surfaces
Authors: Khan Muhammad Saeed , Asif Sajid , Capobianco Antonio‐Daniele , Ijaz Bilal , Anagnostou Dimitris E. , Braaten Benjamin D.
Published: March 2016

Conformal antennas placed on complex surfaces are receiving more attention as a method to increase the coverage of modern wireless communication systems. Furthermore, frequency reconfigurable antennas are being used in the development of multi‐band multi‐radio wireless platforms to simplify designs. In this study, theoretical development and a new 1 × 4 frequency reconfigurable self‐adapting conformal antenna array that can be attached to changing conformal surfaces is presented. This conformal array consists of four reconfigurable microstrip patch antenna elements, a reconfigurable sensor circuit used to measure the curvature of the conformal surface and voltage controlled phase shifters. These phase shifters are controlled by the reconfigurable sensing circuit to implement phase‐compensation to autonomously recover the pattern in both bands of the reconfigurable 1 × 4 array as the wedge‐ and cylindrical‐shaped surface on which the array is attached upon change in shape. Throughout this study, analytical computations, simulations and measurements are compared and shown to agree.
Triple‐band impedance transformers using equal‐length serial transmission lines
Authors: Tsai Lin‐Chuan
Published: March 2016

A new formulation of the fundamental load impedance circuit in the z‐plane is employed to study transformers. The design employs prototypes of transfer function, parametric modelling techniques, and optimisation methods; a model describing multisection transmission‐line transformers is proposed to match load impedance for use in wireless and mobile communication applications. Configuration of the transformer consists of multisection serial transmission lines. This transformer was designed on a PCB FR4 substrate featuring a permittivity of 4.4, a loss tangent of 0.0245, and a thickness of 1.6 mm. Microstrip line circuits were fabricated to verify the feasibility of the technique. The simulation and measurement results show that real and complex load impedances can be matched simultaneously at three different frequency bands. The characteristic impedance values of the transmission lines synthesising the transformers were adjusted according to the autoregressive process by using optimisation algorithms. The experimental results are in agreement with theoretical values.
Low‐profile wide‐beamwidth circularly‐polarised patch antenna on a suspended substrate
Authors: Liu Neng‐Wu , Zhu Lei , Choi Wai‐Wa
Published: March 2016

A low‐profile circularly‐polarised (CP) patch antenna with wide axial‐ratio (AR) beamwidth is proposed. Based on the transmission‐line model, the radiation patterns of a CP patch antenna are calculated by modelling the entire patch as two pairs of equivalent parallel slots. Initially, the mechanism of wide‐beamwidth CP radiation pattern is investigated. The results show that the |Eθ| and |Eφ| radiation patterns can be made nearly equalized over a large angular range, if the spacing L between two parallel slots is selected as 0.45 λ0 (Condition I). For a square patch, the length of each slot must be equal to the spacing L, and it needs to be maintained as one half wavelength at resonance for radiation (Condition II). By using a suspended dielectric substrate, the two above conditions is simultaneously satisfied, resulting to achieve a wide AR beamwidth. After that, the effect of the finite ground size on the 3‐dB AR beamwidth is analysed to constitute a practical CP antenna. Finally, the proposed CP antenna is designed and fabricated. Experimental results are in good agreement with the simulated ones in terms of radiation beamwidth, reflection coefficient and AR bandwidth. Practically, the antenna achieves a wide 3‐dB AR beamwidth of 120°.
Immer auf die Kleinen
Authors: Heuer Claudia
Published: March 2016

Der Ärger über Basisfallwerte ist in der Pädiatrie besonders ausgeprägt. Man kann die kleinen Patienten nicht in den Maßstäben der Erwachsenen Medizin abbilden. Die Uneinsichtigkeit der Krankenkassen könnte schlimme Folgen haben. Das Deutsche Ärzteforum beim Hauptstadtkongress Medizin und Gesundheit 2005 vom 15. bis 17. Juni in Berlin widmet diesem sensiblen Thema eine Sektion.
Pragmatischer Ansatz
Authors: Glatzer Ulrich
Published: March 2016

Heimlich, still und leise hat diesüdspanische Region Andalusien das erste IT-System in Europa etabliert, das im Regelbetrieb die verschiedenen Sektoren des Gesundheitwesens über zentrale elektronische Patientenakten und eine elektronische Gesundheitskarte miteinander vernetzt.
Der Kommunikator
Authors: Heuer Claudia
Published: March 2016

Es war ein Kopf-an-Kopf-Rennen, das erst auf der Zielgeraden entschieden wurde: Jens Horn heißt der “Chief Information Officer des Jahres 2005”. Auf der Bundesgesundheitsgala in Frankfurt am Main wurde er im Rahmen der diesjährigen ITeG mit dem VHitG-Award gekürt. Sein Schlüssel zum Erfolg ist interne Kommunikation.
Sanfte Kontrolle
Authors: Semmler Thomas
Published: March 2016

Das Problem könnte aktueller nicht sein: Anfang Mai wurde aus einer Leverkusener Klinik ein Säugling entführt. Mit einem Baby-Schutzsystem hätte der Fall verhindert werden können. Doch die Furcht vor Elektrosmog hält viele Kliniken davon ab, ein solches System zu installieren. Dabei bieten mehrere Hersteller inzwischen strahlungsarme Systeme an.
Worte ins Bild gesetzt
Authors: Janning Martina
Published: March 2016

Die Wirkung einer Präsentation hängt nur zu etwa zehn Prozent vom Inhalt ab. Über die restlichen 90 Prozent entscheidet das Drumherum. Bedeutend ist die Qualität der Folien. Technisch einfach zu erstellen, ist eine eingängige Gestaltung doch schwer.
Effizienter als gedacht
Authors: Gaede Kirsten
Published: March 2016

Wie lässt sich das Gesundheitswesen günstiger gestalten? Diese Frage beherrscht in den Koalitionsverhandlungen die gesundheitspolitische Diskussion. Sicherlich, die Ausgaben sollten stabilisiert werden. Doch Grund zur Hysterie besteht offenbar nicht.
Die Bewerbungsfrist läuft
Authors: Gaede Kirsten
Published: March 2016

In diesem Frühjahr wurde zum ersten Mal der VHitG-Award in den Kategorien Chief Information Officer (CIO) und IT-Konzept vergeben. Nun folgt die zweite Runde. Auch für die Preisverleihung im nächsten Jahr hat der Verband der Hersteller von IT-Lösungen für das Gesundheitswesen zwei Hauptpreise für einen Chief Information Officer und eine IT-Lösung ausgelobt.
Fehlende Spielanleitung
Authors: Mühlnikel Ingrid
Published: March 2016

Der Vertragswettbewerb in der Integrierten Versorgung ist in vollem Gange. Inhaltlich lassen die Verträge noch zu wünschen übrig. Doch das Ringen um bessere Versorgungsstrukturen ist wichtig und unumkehrbar – meinen Kritiker wie Befürworter.
Freundliche Übernahme
Authors: Heuer Claudia
Published: March 2016

Zur Medica 2005 jährt sich die Absichtserklärung des finnischen IT-Dienstleisters Tietoenator, die ITB AG zu kaufen, zum ersten Mal. Am 31. Januar wurden die Namen unter den Vertrag gesetzt. An die ITB AG hat sich die Tietoenator Corp. angehängt – die niemand kennt.
Alles in private Hände
Authors: Heuer Claudia
Published: March 2016

Die einen müssen, die anderen wollen investieren. Was liegt näher, als die Parteien zusammen zu bringen? Die Rede ist von Kliniken einerseits und Finanzinvestoren andererseits, gemeinsam kann man vielleicht etwas bewegen auf dem deutschen Gesundheitsmarkt. Die Investoren jedenfalls scheinen es ausprobieren zu wollen.
Ein Glücksfall
Authors: Mühlnikel Ingrid
Published: March 2016

Leute wie Rainer Hess sind selten. In Zeiten, in denen es nicht mehr viel zu verteilen gibt, stutzt er den Leistungskatalog der Gesetzlichen Krankenversicherung und liefert sich dabei mit einigen Interessengruppen harte Gefechte. Er macht das mit hohem Engagement und aus Überzeugung. Seiner Wertschätzung tut das keinen Abbruch.
Aussichtslos
Authors: Spielberg Petra
Published: March 2016

Deutschland hat eines der leistungsfähigsten Gesundheitssysteme der Welt – das sollte auch ausländische Patienten anlocken. Doch Versorgung Made in Germany ist keine Erfolgsstory geworden. Die Förderer ziehen sich nun enttäuscht zurück und versuchen es mit Export von Gesundheitsdienstleistungen.
Auf Geldsuche
Authors: Schmidt Hartmut
Published: March 2016

Trotz des großen Interesses auch ausländischer Investoren fällt es vielen Kliniken

und Pflegeheim-Betreibern schwer, Geldquellen zu erschließen. Neue Finanzierungsmodelle könnten jetzt für Abhilfe sorgen.
www.so-faengt-man-kunden.de
Authors: Geisendorf Nicklas
Published: March 2016

Die Homepage im Internet ist ein mächtiges Marketinginstrument, das von vielen Kliniken sträflich vernachlässigt wird. Ob Fachchinesich oder wirre Navigation: kma zeigt die gröbsten Schnitzer auf und verrät, wie es besser geht.
Leasen statt kaufen
Authors: Meinke-Carstanjen Annette
Published: March 2016

Immer mehr Kliniken setzen auf das Leasen von Textilien. Der Umstieg lohnt sich vor allem dann, wenn die Wäsche erneuert oder der Maschinenpark der Wäscherei saniert werden muss. Ein großer Vorteil des Outsourcings ist die Kostenkontrolle: Die Dienstleister können den Wäscheverbrauch pro Fall genau erfassen und so zu Einsparungen beitragen.
Porträt Rudolf Kösters
Authors: Stern Sara
Published: March 2016

Rudolf Kösters ist der neue Präsident der Deutschen Krankenhausgesellschaft (DKG). Kösters ist kein Leisetreter: Er legt sich mit den Ärztegewerkschaften an und hält deren Abspaltung von Verdi für einen Sündenfall. Der Politik wirft Kösters vor, sie handele verantwortungslos, weil sie das Gesundheitswesen im Stich lässt.
Die Kliniken und das Kartellamt
Authors: Glatzer Ulrich
Published: March 2016

Krankenhäuser und ihre Träger versuchen mit allen Mitteln, sich der zunehmenden Kontrolle des Bundeskartellamts zu entziehen.
Der Kunde spielt König
Authors: Heuer Claudia
Published: March 2016

Ist der Kunde mit einem Warenangebot nicht zufrieden, wechselt er den Anbieter. Ist es ein besonders guter Kunde, wird sich der Anbieter auf Bedingungen einlassen, die er kleinen Kunden nicht gewährt. So entstehen Einkaufsgemeinschaften. Die Helios Kliniken GmbH ist im Prinzip eine solche und hat nun ein eigenes Rating-Verfahren mit Folgen für ihre Lieferanten eingeführt.
Das Gesetz bin ich
Authors: Zehnder Adalbert
Published: March 2016

Mit einem selbstherrlichen Führungsstil setzt der Geschäftsführer einer 1000-Betten-Klinik in Oberfranken Ruf und Fortbestand seines Hauses aufs Spiel. Pannen und Skandale häufen sich, das Personal ist frustriert. Jetzt verlangt eineungewöhnliche Protestbewegung aus mundtot gemachten Mitarbeitern, niedergelassenen Ärzten, Honoratioren und Patienten seine Entfernung aus dem Amt.
Schweizer Bündnisse
Authors: Heuer Claudia
Published: March 2016

Es ist eine liebgewonnene Tradition geworden, Firmenübernahmen auf der ITeG bekannt zu geben. Dieses Jahr konnte die Nexus AG am dritten Messetag die Übernahme der Isoft Switzerland GmbH verkünden. Sie verstärkt damit ihr Produktportfolio im Schweizer Markt und generiert nebenbei auch neue Möglich­keiten für den deutschen.
Turbulenter Aktienmonat
Authors: Schmidt Hartmut
Published: March 2016

Nachdem der Aktienmarkt Mitte Mai in einer Woche rund zehn Prozent verloren hatte, sprachen einige Analysten bereits von einer Crash-Gefahr. Dies ist übertrie­ben. Bis heute ist der Kursrückgang allenfalls als Konsolidierung zu werten. Eine latente Gefahr geht aber von den Hedge Fonds aus und weiter steigenden Zinsen.
Unzufriedene Anleger
Authors: Schmidt Hartmut
Published: March 2016

Die Mediclin-Verluste im ersten Quartal stießen dem Markt sauer auf. Der Kurs der Aktie verlor von 4,85 Euro auf 4,10 Euro. Die Börse versteht oft die Saisonalität des Geschäfts nicht. Entscheidend wird das Halbjahres-Ergebnis 2006 sein.
Zum Nulltarif
Authors: Petsch Michael
Published: March 2016

Das zertifizierte Tübinger Brustzentrum bietet medizinische Versorgung auf höchstem Niveau. Leiter Diethelm Wallwiener beklagt: Diese Leistung wird nicht honoriert und er warnt vor missbräuchlicher Verwendung des Begriffs Zertifizierung.
Köche Rechner
Authors: Oelschlegel Florian
Published: March 2016

“Kochen? – Das können wir auch”, rufen die Klinikköche. Und sie haben selbstverständlich Recht. Doch die Caterer und großen Health-Care-Firmen übernehmen mehr und mehr auch Aufgaben rund ums Kochen und Servieren. Ein kleiner Überblick.
Gut beraten
Authors: Sickinger Nina
Published: March 2016

Verbandsnachrichten der FKT - Fachvereinigung Krankenhaustechnik (e. V.). Diese Seiten sind nur als PDF-Dokument verfügbar.
Schlechte Esser sind teuer
Authors: Janning Martina
Published: March 2016

Klinikärzte und Schwestern achten zu wenig auf den Ernährungszustand ihrer Patienten. Dabei sind viele schon bei der Aufnahme mangelernährt. Dieser Zustand setzt sich im Krankenhaus fort. Schuld ist vor allem das Essverhalten.
Keine Ahnung
Authors: Mühlnikel Ingrid
Published: March 2016

Seit dem 1. Juli gilt der Tarifabschluss eines ärztespezifischen Vertrags an den Unikliniken und Landeskrankenhäusern.
Abschied vom Ölkännchen-Geschäft
Authors: Zehnder Adalbert
Published: March 2016

Als eine der ersten Klinikketten hat die MTG ihre IT konsequent outgesourct und zentralisiert – ein heikles Unterfangen angesichts von Sicherheitsrisiken und Datenschutz. Das IT-Personal definiert gleichzeitig seine Aufgabe völlig neu: weg vom administrativen Geschäft, hin zur Ressourcensteuerung im Unternehmen Krankenhaus.
Architektur im Dialog
Authors: Heuer Claudia
Published: March 2016

Nützliche Dinge des Alltags bekommen oft nicht die Wertschätzung, die sie verdienen. Genau so verhält es sich aus Sicht von Architekten auch in vielen Fällen mit den Gebäuden, in denen wir leben und arbeiten. Im Gesundheitswesen entdecken die Bauherren jetzt, dass sich die richtige Bauweise für den gesamten Klinikbetrieb auszahlen kann.
Der Segen der Sicherheitstechnik
Authors: Geisendorf Nicklas
Published: March 2016

Der tote Demenzpatient in einem Technikraum und der vergessene Patient im Fahrstuhl im Juni in Berlin werfen ein Schlaglicht auf ein häufiges Manko der Kliniken: die Sicherheit von Schutzbedürftigen. Viele nutzen leider nicht besondere Vorkehrungen und die modernen Sicherungstechniken.
Therapien gegen Energiefresser
Authors: Niermann Inga
Published: March 2016

Die Preise für Heizung und Strom steigen unaufhörlich und werden immer schwerer kalkulierbar. Um nicht von den Energiekosten überrollt zu werden, müssen Kliniken ihren Verbrauch so stark wie möglich drosseln.
Erfolg auf der ganzen Linie
Authors: Sickinger Nina
Published: March 2016

Verbandsnachrichten der FKT - Fachvereinigung Krankenhaustechnik (e. V.). Diese Seiten sind nur als PDF-Dokument verfügbar.
Europa im Visier
Authors: Heuer Claudia
Published: March 2016

Ein rasantes Tempo hat Tietoenator in den letzten zwei Jahren vorgelegt: von null auf Platz drei der deutschen Krankenhaus-Software-Anbieter, Siemens dabei dicht auf den Fersen. Der bislang letzte Streich war die Akquisition der Bochumer Cymed AG. Nun heißt es erst einmal integrieren und befruchten und der Zukunft näher kommen.
Unsicherheit bis Ende März
Authors: Schmidt Hartmut
Published: March 2016

Mediclin wird seine Planung für dieses Jahr erst im März veröffentlichen. Die Unsicherheit bleibt also. Sicher ist, dass sich die Zahlen 2006 mit einem Umsatzplus um 2 Prozent und einer Steigerung des Gewinns pro Aktie (EpS) um 25 Prozent im Plan befinden.
Kassen auf Krawall
Authors: Niermann Inga
Published: March 2016

Krankenkassen versuchen immer häufiger, die Folgekosten von Stürzen auf die Heime abzuwälzen. Viele Fälle werden inzwischen vor Gericht ausgefochten. Allein um sich zu schützen, müssen die Einrichtungen den Expertenstandard Sturzprophylaxe umsetzen.
Ende der Datensammelei
Authors: Ehrhardt Jana
Published: March 2016

Die AOK und die Helios Kliniken haben ein unbürokratisches Verfahren zur Qualitätssicherung entwickelt. Als Datengrundlage dienen Abrechnungsdaten. Eine Extragenerierung von Datensätzen wie beim BQS-Verfahren ist überflüssig, meinen die Projektpartner.
Die Besten auf einen Blick
Authors: Gaede Kirsten
Published: March 2016

Patientenschulungen werden immer wichtiger, für Rehakliniken, aber auch für die Krankenhäuser. Das zeigt sich schon an den aktuellen Leitlinien für chronische Krankheiten wie die koronare Herzkrankheit und Diabetes.
Kalkulationen im Fünfjahresrhythmus
Authors: Mühlnikel Ingrid
Published: March 2016

kma-Interview mit Martin Reich, Leiter Abteilung Controlling am AKH-Wien – Universitätskliniken.
Dämpfer durch den Dollar
Authors: Schmidt Hartmut
Published: March 2016

Fresenius steht nicht schlecht da: Die Zahlen für das 1. Quartal 2007 haben die Erwartungen erfüllt, das Unternehmen hält an seinen Planungen für 2007 und Perspektiven bis 2010 fest. Trotzdem: Seit Anfang Mai ist der Aktienwert um 6 Prozent geschrumpft.