bluuebunny/crossref_metadata_2025 huggingface dataset:
ANATOMICAL VARIABILITY OF CUTANEOUS NERVES OF ANTERIOR FEMORAL REGION IN HUMAN FETUSES
Authors: Hryhorieva Pavlina V. , Khmara Тatiana V. , Palamar Аlina О. , Sykyrytska Тetyana B. , Leka Maryna Yu.
Published: April 2021

The aim: Is to find out the features of innervation of the skin of the anterior femoral region and the fascia lata during the fetal period of human development.
Materials and methods: The study was carried out on 64 preparations of the lower extremities of human fetuses of 4-10 months using macromicroscopic preparation and morphometry.
Macropreparations of the skin nerves of the lower extremities of different age fetuses with anatomical variants were subject to photo documentation.
Results: The features of cutaneous nerve fetal topography of the anterior femoral region and the broad fascia of the femur were revealed, their connections were established, and their
layering was determined. It was found that in human fetuses, not only the lateral cutaneous femoral nerve but in most cases the branches of other nerves of the lumbar plexus, except
for the obturator nerve, are directed to the skin of the anterior-lateral femur surface. The innervation of the medial femur surface is provided by the following nerve complex: obturator,
femoral, saphenous and genitofemoral nerves.
Conclusions: Taking into account the fact that the terminal branches of adjacent cutaneous nerves of the femoral region intersect and overlap, innervation bypasses are formed, due to
which, in case of possible damage to one of the nerves, its insufficiency is compensated to a certain extent.
Anastomoses were found between the cutaneous nerves, in the form of loops of various shapes and sizes, namely: between the cutaneous-fascia branches of the femoral and ilioinguinal
nerves and the femoral and obturator nerves.
MORPHOLOGICAL FEATURES OF RATS’ HEARTS AFTER INTRAFETAL INJECTION OF DEXAMETHASONE
Authors: Hryhorieva Olena A. , Chernyavskiy Arthur V. , Guminskiy Yuriy Yo.
Published: April 2021

The aim: Is to study the morphological features of rats’ hearts after prenatal administration of glucocorticoids.
Materials and methods: In this study we used histological, immunohistochemical, electron-microscopic and statistical research methods.
Results: It is found that at 30th day after birth in rats after intrafetal introduction of dexamethasone in myocardium a relative area occupied by arterial vessels is significantly
smaller in comparison with control. Absolute and relative number of Ki-67+-cardiomyocytes in the myocardium of experimental rats is reduced throughout the second week
after birth and is significantly less compared to the control group. In the nuclei of cardiomyocytes of experimental rats is rendered the greater amount of heterochromatin in
comparison with cardiomyocytes of the control group where euchromatin prevails.
Conclusions: After intrafetal injection of dexametazone changes in dynamics and significantly smaller index of relative area occupied by arterial vessels in ventricular
myocardium at the 30th day after birth are observed; the absolute and relative number of Ki-67+ -cardiomyocytes in myocardium decreases during the second week after
birth and is significantly lower compared to the control group; in the nuclei of cardiomyocytes of experimental rats a greater amount of heterochromatin is visualized, and in
cardiomyocytes of the control group – euchromatin.
METABOLIC SYNDROME, OVERWEIGHT, HYPERLEPTINEMIA IN CHILDREN AND ADULTS
Authors: Bochar Olesia M. , Sklyarova Helena Y. , Abrahamovych Khristina Y. , Hromnats'ka Natalia M. , Bochar Volodymyr T. , Sklyarov Eugen Y.
Published: April 2021

The aim: To evaluate anthropometric, hemodynamic parameters, as well as changes in blood and leptin lipid spectrum in children and adults with overweight and obesity.
Materials and methods: We examined 68 overweight children and 90 patients with obesity in combination with stage 2, grade 2 AH who were electively inpatient. The control
group consisted of practically healthy individuals – 20 adults and 55 children.
Results: Obesity in childhood isaccompanied by the development of dyslipidemia, hypercholesterolemia, hyperleptinemia and hypertension, and in adulthood may be an
additional risk factor for cardiovascular disease, in particular AH. According to the study, total leptin level in overweight children was significantly higher compared to the
control group (p<0.01). The concentration of leptin in patients with hypertension in combination with obesity was 3 times higher compared to the control group (p<0.01)
Conclusions: Thus, obesity or overweight, accompanied by hyperleptinemia and an increase in the proatherogenic fractions of the blood lipid spectrum, is an important problem
that needs to be addressed in childhood to prevent cardiovascular disease in adulthood.
NIKOLAI IVANOVICH PIROGOV – AMICUS HUMANI GENERIS
Authors: Bieliaieva Olena M. , Skrypnikova Taisa P. , Lysanets Yuliia V. , Morokhovets Halyna Yu. , Slipchenko Larysa B. , Efendiieva Svitlana M.
Published: April 2021

The aim: Was to analyze the scientific and pedagogical heritage of N.I. Pirogov through the prism of his outstanding polymathic abilities.
Materials and methods: The authors examined the scientific and pedagogical heritage of N.I. Pirogov using the method of historiographical analysis, as well as the methods
of synthesis and generalization. The study relies on research publications devoted to N.I. Pirogov’s biography, as well as his epistolary and autobiographical works.
Conclusions: The scientific novelty of the research is that the biography of N. Pirogov is represented with refinements and additions based on his latest work “From the Diary
of an Old Doctor”. The authors analyzed the epistolary heritage of N. Pirogov, which served as a valuable biographical source. Given the anthropocentrism of the current stage
of the existence of society and European civilization, the authors sought to “revive” the biography of N. Pirogov. In this regard, considerable attention is paid to his personal life.
As a result, the article considers this outstanding personality in a new perspective, presenting the main stages of his scientific and medical activity.
MORPHOLOGICAL CHANGES OF THE ENDOMETRIUM IN HYPERPLASTIC PROCESS IN WOMEN OF REPRODUCTIVE AGE
Authors: Vereshchahina Tetiana V. , Boychuk Alla V. , Yakymchuk Yuliia B. , Nikitina Iryna M. , Datsko Tetiana V.
Published: April 2021

The aim: To conduct a morphological study of endometrial tissue to identify changes characteristic of viral lesions to develop improved antirelapse treatment of HPE in women
of reproductive age.
Materials and methods: We surveyed 90 patients of the gynecological department who sought medical for hyperplastic processes of the endometrium in reproductive age.
All women underwent hysteroscopy, the resulting material was subjected to morphological examination.
Results: It became known that the virus is involved in the pathogenesis of endometrial hyperplasia. It is likely that it exists in epitheliocytes not only as a “passenger”, but
also as an etiological factor. It became known that it was in complex hyperplasia with atypia that the percentage reached the highest level, which is a precancerous condition.
Conclusions: Typical morphological change of the endometrium – multinucleation, multinuclearity and koilocytotic atypia in women of childbearing age with HPE – was revealed.
The presence of infectious pathogens in the endometrium of patients with HPE can be regarded as one of the possible triggers for the development of hyperplastic processes.
HEALTHCARE ASSOCIATED DEEP PELVIC TISSUE INFECTION AND OTHER INFECTIONS OF THE FEMALE REPRODUCTIVE TRACT IN UKRAINE
Authors: Salmanov Aidyn G. , Suslikova Lidiya V. , Pandei Svitlana A. , Rud Victor O. , Kokhanov Igor V. , Butska Victoria Ye. , Tymchenko Alexander G.
Published: April 2021

The aim: To obtain the first estimates of the current prevalence of healthcare-associated deep pelvic tissue infection and other infections of the female reproductive tract
(vagina, ovaries, uterus) including chorioamnionitis, and antimicrobial resistance of causing pathogens in Ukraine.
Materials and methods: We performed a retrospective multicenter cohort study was based on surveillance data. The study population included 3,053 women’s who underwent
gynecological surgery or other procedures from 2017 to 2019 in 7 women hospitals in Ukraine. Definitions of healthcare-associated reproductive tract infection were used from the CDC/ NHSN.
Results: The prevalence of healthcare-associated deep pelvic tissue infection and other infections of the female reproductive tract was 26.3%. Incidence of infection was:
13.3% Pelvic abscess or cellulitis, 14.6% Adnexa utery, 9.5% Salpingitis, 7.1% Oophoritis, 12.2% Parametritis, 4.6% Chorioamnionitis, and 38.8% Bacterial Vaginitis. The
predominant pathogens were: Escherichia coli (25.6%), Enterobacter spp. (11.4%), Klebsiella pneumoniae (10.6%), Staphylococcus aureus (8.5%), Enterococcus faecalis (7.2%)
and Pseudomonas aeruginosa (7.1%). Methicillin-resistance was observed in 14.3% of S. aureus (MRSA). The overall proportion of extended spectrum beta-lactamases (ESBL)
production among Enterobacteriaceae was 20.8%. The prevalence of ESBL production among E. coli isolates was 24.7% and among K. pneumoniae 11.9%. Resistance to thirdgeneration
cephalosporins was observed in 12.8% E.coli and 9.2% K. pneumoniae isolates.
Carbapenem resistance was identified in 8.5% of P.aeruginosa isolates.
Conclusions: Healthcare associated deep pelvic tissue infection and other infections of the female reproductive tract in Ukraine is a common occurrence and many cases are
caused by pathogens that are resistant to antibiotics.
APPLICATION OF INTELLECTUAL MONITORING INFORMATION TECHNOLOGY IN DETERMINING THE SEVERITY OF THE CONDITION OF PATIENTS WITH INFLAMMATORY BOWEL DISEASES
Authors: Dorofeyev Andriy E. , Holub Sergiy V. , Babayeva Gulustan H. , Аnaniin Оleg Е.
Published: April 2021

The aim: Was to evaluate the effectiveness of the use of information technology of intelligent monitoring in solving the problems of assessing the morbidity of a patient with IBD during treatment.
Matherials and methods: 183 patients with IBD were observed. Among them 104(56.8%) patients suffered from Crohn’s disease and 79(43.1%) patients had ulcerative colitis.
For each patient and each disease, the formation of a list of signs, the extraction of information and knowledge will be carried out according to an individual method. At the lower level, tasks are performed: determination of the list of patient morbidity conditions, the formation of a list of indicators of the patient morbidity conditions, their identification as classes for machine learning models; formation of a list of signs, which identify the state of the patient’s morbidity and whose characteristics obtained after results of medical tests.
Results: The number of correctly classified points reached 92%. An analysis of the conditions of patients characterized by incorrectly classified points revealed the information content of this fact. In those cases when the classification results did not coincide with the expert assessment of the patient’s condition, additional factors were found that influenced his condition and whose characteristics were not taken into account in the structure of classifier models.
Conclusions: The results of the testing of classifier models indicate the effectiveness of the use of information technology of intelligent monitoring to assess the condition of
patients with IBD.
NON-SURGICAL TREATMENT OF PEYRONIE’S DISEASE: A COMPREHENSIVE REVIEW
Authors: Chernylovskyi Volodymyr A. , Krakhotkin Denis V. , Chaikovskyi Viktor P.
Published: April 2021

This review article focuses on conservative treatment options, topical, intralesional therapy, traction and vacuum therapy. A PubMed database search was performed for studies that were published between 1948 and 2019. Search keywords included “Peyronie’s disease,” “conservative therapy,” “traction treatment,” “extracorporeal shock wave therapy,” “topical and oral therapies,” and “vaccum therapy.” Clinical trials in men with Peyronie’s disease and scientific articles relating to pharmacologic data were included in the review. When possible, large, randomized, and well-designed trials were selected. Non-English-language articles were excluded.
RESEARCH OF PSYCHOLOGICAL READINESS OF DOCTORS TO ADAPTIVE TRAINING
Authors: Koshova Svitlana P. , Hbur Zoriana V. , Kolomoyets Andriy V.
Published: April 2021

The aim: To empirically investigate the psychological readiness of physicians for adaptive learning during the acquisition of professional competences in the system of
postgraduate medical education.
Materials and methods: We surveyed a sample of 148 physicians who began studying the discipline of Psychology of Conflict, which was specially developed by us on the
principles of adaptive learning. There were three occupational groups among doctors: surgeons (n = 47), therapists (n = 53) and pediatricians (n = 48).
In the work a range of methods are used: content analysis, biblio-semantic, systematic approach, analysis of products of activity, psycho-diagnostic methods.
Results: When characterizing the identified and calculated integral indicators, the most pronounced for the entire study sample is the desire for dominance (85%), adaptation
and emotional comfort at 75%. The lowest percentage of self-perception – 65%, slightly higher internality (68%). Acceptance of others at 78%.
In general, the dominant factor of the 148 physicians was service motived, indicating that this group is truly focused on the benefit of their patients and others. Our researchers
perceive their work as a service, as a means of being useful to people, society and humanity as a whole. This is an indicator of high readiness for adaptive learning in the
postgraduate medical education system.
The results of the method of “Self-regulation style of behavior” by the doctors of the three medical specialties studied by us testify to their readiness for active inclusion in the
system of adaptive training in postgraduate medical education.
Conclusions: Based on the results of our empirical study, we are able state that the doctors who participated in the study are ready for adaptive training in the system of
postgraduate medical education. The results of our research can be basis for drafting recommendations for adaptive education, which can be grounded on a competent approach.
HEMOSTATIC POTENTIAL ASSESSMENT OF PATIENTS WITH LIVER CIRRHOSIS AND ATRIAL FIBRILLATION BY LOW-FREQUENCY PIEZOELECTRIC THROMBOELASTOGRAPHY
Authors: Baylo Alina E. , Maksymets Tetiana O. , Shypulіn Vadym P. , Chernyavskyi Volodymyr V. , Parunian Luiza M.
Published: April 2021

The aim: Our aim was to assess the hemostatic potential of patients with liver cirrhosis and atrial fibrillation by LPTEG global coagulation assay, to investigate changes in LPTEG parameters
according to the stage of liver cirrhosis and compare results with liver cirrhosis group.
Materials and methods: We performed a prospective cross-sectional study including 70 patients with liver cirrhosis and atrial fibrillation, 36 patients with liver cirrhosis and
20 healthy individuals. LPTEG parameters were measured using ARP-01M “Mednord” in order to assess coagulation abnormalities.
Results: t1 and Intensity of contact coagulation didn't differ (p>0,05), Constant of thrombin activity was increased (47.53±0.8vs.34.51±1.88, p<0.001), t3 was reduced
(5,0±0.1vs.6.7±0.36 p<0.001), Intensity of coagulation drive was increased (52.8±1.8vs.38.55±1.54, p = 0.001), Intensity of clot polymerization was increased (19.66±0.28vs.16.29±0.28,
p<0.001), time t5 was reduced (32.94±0.36 vs. 36.8±1.30, p<0.01), Maximum amplitude was increased (655.7±9.19 vs. 547±19.38, p<0.001), Intensity of total coagulation
was increased (19.41±0.34vs.15,09±0.56, p<0.001), Intensity of clot retraction and lysis was increased (4.1±0.07vs.3±0.15, p<0.001) and Coefficient of total anticoagulant
activity was increased (2.81±0.05 vs. 2.48 ± 0.06, p<0.001) compared to liver cirrhosis.
Conclusions: In patients with liver cirrhosis and atrial fibrillation the hemostatic potential is significantly shifted towards hypercoagulation with a gradual worsening of
coagulation disorders, starting from the compensated stage of liver cirrhosis.
THE MODIFYING ROLE OF TOXIC SUBSTANCES ON GENOTOXIC EFFECT IN THE BODY DURING COMBINED ADMINISTRATION WITH CARCINOGEN (BENZO[A]PYRENE)
Authors: Ostash Olga M. , Grygorenko Liudmyla E. , Shvager Oksana V. , Stepanchuk Svetlana V. , Balenko Nina V. , Chernychenko Igor O.
Published: April 2021

The aim: of this work was to experimentally study the modifying role of toxic substances (phenol) in the manifestation of genotoxic and immunological changes in the body
when exposed to a carcinogen (benzo[a]pyrene).
Materials and methods: Investigations were carried out in the chronic experiment on white random-bred male mice. Genotoxic (micronucleus test), immunologic and
pathomorphological methods were used.
Results: As a result of the experiment on white outbred mice during the isolated peroral administration of benzo[a]pyrene (a single dose of 0.1 mg) and in combination with
phenol (single doses of 0.1 mg; 0.002 mg) a carcinogenic effect (forestomach papillomas) has been established as well as general patterns of the manifestation of genotoxic and
immunological changes regarding carcinogenesis and their dependence on the dose and duration of the administration of the substances in the early stages of the experiment.
The established patterns involved parallelism of development and unidirectionality of the genotoxic effect (increasing of micronucleus incidence) and suppression of the T-cell immunity by the end of the month as well as reliable negative correlation between them.
Conclusions: It has been established that phenol has a modifying effect on carcinogenesis, which was shown as an increase in the micronuclei frequency, intensification of immunosuppression in the early stages and an increase in the multiplicity factor of the development of forestomach tumors.
BIOCHEMICAL MARKERS OF ENDOTHELIAL DYSFUNCTION, THEIR CHANGES UNDER THE INFLUENCE OF TREATMENT WITH VARIOUS BETA-ADRENOBLOCKERS IN YOUNG MEN
WITH MYOCARDIAL INFARCTION
Authors: Andrieiev Ievgenii V. , Makukha Yulia M. , Kravchenko Anatoliy M. , Gayova Ludmila V.
Published: April 2021

The aim: Is to determine the levels of markers of endothelial dysfunction in young men with myocardial infarction and their changes during the treatment with beta-blockers
with different pharmacological properties.
Materials and methods: 112 male patients of Caucasian race of the Ukrainian population under the age of 50 with MI. Group I received Nebivolol, group II – bisoprolol.
Results: During the 6-month follow-up, positive dynamics of NOS-2 and ET-1 was observed. The level of NOS-2 in groups I – II was 4272.3±162.7, 4629.7±161.2 pg/mL,
respectively (p<0.05). The dynamics of ET-1 showed significant decrease of its level in all groups
Conclusions: Significant changes in markers of endothelial dysfunction, namely NOS3/eNOS, NOS2/iNOS and ET-1, are observed in young male patients of the Ukrainian population with MI. During 6 months of treatment, positive changes were observed in the form of an increase in NOS-3 levels and a significant decrease in ET-1 and NOS-2 levels. The inclusion of Nebivolol in the basic therapy for this group of patients is associated with an additional positive effect on the normalization of levels NO synthase and the reduction of ET-1.
RESEARCH OF THE ACTUAL ENERGY CONSUMPTION OF THE MILITARY PERSONNEL OF THE ARMED FORCES OF UKRAINE TO SUBSTANTIATE THE CORRECTION OF THEIR DAILY DIET
Authors: Deputat Yurii N. , Ivanko Olesia M. , Savitskyi Valerii L. , Kazmyrchuk Anatoliy P. , Gyluch Maria P. , Palamar Borys I.
Published: April 2021

The aim: Is to determine the actual energy costs of servicemen on the qualification course of special operations of the Armed Forces of Ukraine to substantiate the adequate nutritional and energy value of their diet.
Materials and methods: The actual average daily energy consumption of 85 servicemen of the qualification course (hereinafter – Q-course) of special operations of AF of
Ukraine was determined by time-table and instrumental methods. By laboratory, calculation and questionnaire methods, the compensatory possibilities of their actual nutrition were assessed.
Results: The data obtained indicate that the highest indicators of energy expenditures among servicemen were during the first phase of selection of the Q-course at the level of an average value of 6853 ± 963.9 kilocalories (hereinafter – kcal) per day. At the same time, the calorie content of actual food consumed only by 55.7% provided compensation for the average daily energy costs.
In this regard, we have developed and implemented “Organizational and Methodological Guidelines for Rational Nutrition of Servicemen of SOF of AF of Ukraine”.
Conclusions: The actual nutrition of the military personnel on the Q-course of SOF of AF of Ukraine does not fully compensate for their real energy losses. The nutritional and
energy value of the daily diet requires revision and bringing it into line with the actual energy consumption, depending on the preparation phases.
VALUE ATTITUDE TO HEALTH AS THE BASIS OF AN ACTIVE LIFE POSITION OF AN INDIVIDUAL
Authors: Harashchenko Larysa V. , Kondratiuk Svitlana G. , Palamar Svitlana P. , Vaskivska Halyna O. , Nezhyva Liudmyla L.
Published: April 2021

The aim: Studying of the aspects that influence the formation of future teachers' values to health as the basis of an active life position of an individual.
Materials and methods: To update the didactic aspects of the problem, we used the methods of analysis of normative and scientific sources, system analysis and generalizations,
the results of our own empirical studies, materials of the questionnaire, active modeling of students' health value formation.
Results: The formation of a value attitude to the problem of health in future teachers is carried out under the following conditions: awareness of the importance of the value of
health; changing the attitude of the individual to his/her own health and the health of others; knowledge of the factors influencing health, a conscious desire to lead a healthy lifestyle and make efforts to care for health, the use in the educational process of the operational model of forming students' value attitude to health by mastering the content of the course “Health-saving technologies in education” in order to form the ability of a systematic understanding of health-saving activities.
Conclusions: The formation of the value attitude of teachers to the problem of health involves taking into account all components of health and is possible provided within the condition of continuity of educational impact on the individual.
MELATONIN AND GRHELIN AS “EARLY” PROGNOSIS MARKERS OF PROGRESSION OF ARTERIAL HYPERTENSION AND OSTEOARTHRITIS IN THE CASE OF THEIR COMORBIDITY
Authors: Sobko Diana I. , Ilashchuk Tetiana O. , Navchuk Ihor V.
Published: April 2021

The aim: Of the study was to investigate the effect of melatonin on the serum levels of ghrelin in patients with hypertension combined with osteoarthritis in order to identify
them as informative and reliable markers of early diagnosis of progression of these comorbid diseases.
Material and methods: To achieve the goals and objectives of this study, 60 patients with hypertension combined with osteoarthritis were involved and examined, in particular,
serum ghrelin and melatonin levels were determined twice and divided into two groups.
Results: It was found that in patients of group I on the background of the four-week main course of treatment with the addition of melatonin (3 mg 1 time per day before
bedtime), the average value of ghrelin increased by an average of ± 2.05 ng/ml (p <0,05). In patients of group II, who, in addition to their usual treatment, did not receive
additional melatonin, the dynamics of ghrelin growth was lower, on average increased by ± 0.54 ng/ml (p <0.05). It was also found that the higher the BMI, the lower the
serum ghrelin in the examined patients (r = -0.56, p <0.01).
Conclusions: The data obtained show the correlation between ghrelin and melatonin concentrations (r = +0.72, p < 0.001) in patients with hypertension associated with OA.
Therefore, indicators of their levels can be used as “early” reliable prognostic markers of development and progression of these mentioned comorbid pathologies.
RESOURCES TO IMPROVE THE EFFECTIVENESS OF PERIODONTAL TREATMENT IN PATIENTS WITH DIABETES MELLITUS
Authors: Biloklytska Galyna F. , Viala Svitlana Yu.
Published: April 2021

The aim: Is to characterize the «Medico-sociological map» developed by us to identify systemic and local risk factors for periodontal disease in patients with type I and II diabetes
mellitus as a resource to improve the treatment of generalized periodontitis.
Materials and methods: We have developed a Medic-sociological map to identify systemic and local risk factors for periodontal disease in patients with type I and type II
diabetes mellitus. Methods of accumulation of primary dental and endocrinological information, review and analytical methods. Statistical methods for comparing empirical
data and their generalization.
Results: Thanks to the «Medico-sociological map» developed by us, systemic and local risk factors for the development of periodontal tissue diseases in patients with type I
and II diabetes mellitus have been identified. Factors for improving the well-being of patients in the treatment of periodontal diseases have been comprehensively studied.
Patients with type 1 and type 2 diabetes mellitus have been shown to give up healthy habits (cigarette smoking) and lead a healthy lifestyle and reduce the health risks that
can be caused by generalized periodontitis in combination with diabetes mellitus.
Conclusions: It has been demonstrated that resources to improve the effectiveness of periodontitis treatment in patients with diabetes mellitus include not only cooperation
with endocrinologists, but also our «Medico-sociological map» to identify systemic and local risk factors for periodontal disease in patients with type I and II diabetes mellitus.
COMPARATIVE HYGIENIC ASSESSMENT OF WORKING CONDITIONS AND OCCUPATIONAL RISK IN THE APPLICATION OF PESTICIDES (ON THE EXAMPLE OF FUNGICIDE AMISTAR EXTRA 280, SC) USING DIFFERENT TYPES OF SPRAYERS
Authors: Borysenko Аndrii А. , Antonenko Аnna М. , Omelchuk Sergii Т. , Bardov Vasyl G. , Vavrinevych Olena P.
Published: April 2021

The aim: Was a comparative hygienic assessment of working conditions and occupational risk in the application of fungicide Amistar Extra 280, SC using slotted and injector sprayers.
Materials and methods: Sprayers Super Poly 110-04 (variant №1) and Guardian Air GA110-04 (variant № 2), and certified equipment were used. The occupational risk was
assessed in accordance with the methodological recommendations proposed by the L.I. Medvedia Scientific Center for Preventive Toxicology, Food and Chemical Safety specialists.
Results: When using the slotted sprayer Super Poly 110-04 in the air of the working zone of the tractor driver the content of azoxystrobin was 0.0015 ± 0.0001 mg/m3,
cyproconazole – 0.085 ± 0.002 mg/m3, at a distance of 10 m from the edge of the field on the leeward side – 0.003 ± 0.001 and 0.11 ± 0.02 mg/m3, respectively. Visual analysis
of water-sensitive cards after using slotted sprayers showed the presence of single drops of pesticide working solution in the wear zone.
When applying the pesticide using a Guardian Air GA110-04 injector sprayer in the air of the working zone of the tractor driver, areas of possible wear (10 and 100 m), the
concentration of the active substances of Amistar Extra 280, SC formulation was below the limit of quantification of the method.
When assessing the complex risk for tractor drivers, a statistically significant difference was found for azoxystrobin (p = 0.002) and cyproconazole (p = 0.001) when using a
slotted sprayer Super Poly 110-04 and injector Guardian Air GA110-04.
Conclusions: Values of the combined complex risk of application of the Amistar Extra 280, SC formulation for tractor drivers of variant №2 application were significantly lower
than those for tractor drivers of variant №1.
APPROACHES TO DEVELOPING AND IMPLEMENTING CLINICAL AND ORGANIZATIONAL REGULATIONS ENSURING INFECTIOUS SAFETY AND EPIDEMIOLOGICAL RESPONSE IN THE WORK PROCESS (THE CASE OF COVID-19)
Authors: Dyachuk Dmytro D. , Zyukov Oleg L. , Оshyvalova Оlena О. , Yashchenko Yuriy B. , Lishchyshyna Olena M.
Published: April 2021

The aim: Of the work was to develop clinical and organizational regulations ensuring infectious safety and epidemiological response in the work process (the case of COVID-19)
based on the current legislative acts of Ukraine to combat the spread of coronavirus disease (COVID-19), as well as on the data from international practices.
Materials and methods: The research objective was carried out in accordance with the Methodology for the development of medical and technological documents for the
standardization of medical care.
Results: The Protocol includes organizational elements to prevent the spread of coronavirus disease, such as “The development of general provisions on infectious safety and
antiepidemic measures during the COVID-19 pandemic in the company's workplaces, taking into account the legislative acts of Ukraine and international practices”, which
include: the development of “Health Questionnaire” (epidemiological data questionnaire) for daily monitoring of the company employee health; the development of “Checklist
for self-assessment of the workplace”, “Checklist for self-assessment of the public space”; the development of “Analytical report on compliance with the infectious safety rules
in the workplace and in the public space on the basis of self-assessment”, thirteen Appendices.
Conclusions: “The Protocol for infectious safety and antiepidemic measures in the work process” is a detailed instruction that provides a balance of compliance with medical
standards and reasonable needs of employees and employers through the implementation of scientific evidence base in antiepidemic and infectious safety measures in the workplace.
STUDENTS' HEALTH STATUS AND THEIR ABILITY TO ADAPT TO A MULTINATIONAL UNIVERSITY ENVIRONMENT
Authors: Меlnychenko Oleksandr A. , Ognev Viktor A. , Marakushin Dmytro I. , Isaieva Inna M. , Batyuk Liliya V. , Chovpan Ganna O. , Melnychenko Vladyslav O.
Published: April 2021

The aim: Development of practical recommendations to further improve students' adaptation to a multicultural university environment as a factor in ensuring their health.
Materials and methods: The publication is based on the results of a comprehensive multi-purpose randomized epidemiological study using a standardized questionnaire.
Questionnaire results (n = 355) were tested for paired correlations of all considered factors.
Results: 93,8 % of respondents positively assessed their overall health with a mode of 3 (satisfactory health). In general, students' health was not particularly sensitive to the
effects of temporal and natural factors. Recommendations have been developed to improve students' adaptation to the university's multinational environment, including by
preventing stressful situations. It is important that students are sufficiently informed, financially secure, and mentally prepared for student life.
Conclusions: The key to safeguarding students' health is developing their skills in adapting to a multinational university environment.
COMPARATIVE ANALYSIS OF THE MAIN SOCIAL HEALTH DETERMINANTS OF LIFE EXPECTANCY AND INFANT MORTALITY IN UKRAINE AND POLAND
Authors: Gutor Taras G. , Zaremba Natalia I. , Kovalska Oksana R. , Moskviak-Lesniak Dzvenyslava Je. , Gerasymovych Iryna M. , Kobyletskyy Oleh Ja. , Nahurna Yaryna V.
Published: April 2021

The aim: To analyze the data of social health determinants – life expectancy of population and infant mortality in neighboring countries: Ukraine and Poland in cut-away of
territory habitation.
Materials and methods: The statistical materials of the Ukrainian and Polish information sources were used in this work: SI “The center of medical statistics of the Ministry of
Health of Ukraine”, The state statistics service of Ukraine, The central statistical management of Poland (Główny Urząd Statystyczny). Methods of system approach, bibliosemantic,
statistical, analytical were used for analysis.
Results: In both countries, Poland and Ukraine, the general dynamics as to the growth of an average life expectancy (ALE) among men and women was observed during 28 years
of surveillance, and in both countries it was revealed that the ALE indices in women were much higher than in men. Within the last five years, there is a considerable tendency
of decrease in the infant death rate in Ukraine, while in Poland this index is particularly invariable. This may be due to the fact that the level of infant mortality in Poland is half
the level in Ukraine; moreover, this correlation is approximate within the last five years of observation. A significant place in the structure of all the causes of infant mortality
in 2019 is occupied by the ХVІ chapter in accordance with ICD-10 “Certain conditions originating in the perinatal period” – 54.39 % in Ukraine and 53.05 % in Poland, the last
– “Diseases of the Urogenital system” (chapter ХІV) – 0 % and 0.7 %, correspondingly.
Conclusions: With a view of an incessant improvement of a high-quality information which is registered when the statistical data are formed, it is necessary to promote a broad
intersector cooperation inside the countries and international collaboration between the countries.
AN OVERVIEW OF AUTOIMMUNITY IN IMPLANTATION FAILURE: A LITERATURE REVIEW
Authors: Berestoviy Vladyslav O. , Mahmood Ahmad A. , Berestoviy Oleg O. , Ginzburg Valentyna G. , Govsieiev Dmytro O.
Published: April 2021

The aim: This review was aimed to understand the role of different types of autoantibodies like antiphospholipid, antithyroid, antisperm, antinuclear, anti-ovarian autoantibodies and heat shock protein HSP 60 in the process of implantation in the normal way of conceiving and IVF and also to estimate that how the presence of these autoantibodies affect the normal pregnancy outcome.
Materials and methods: This review process performed in the obstetrics and gynaecology postgraduate department, Bogomolets national medical university, Kyiv, Ukraine. It was a review of already published papers not to need the ethical board committee's approval. By following the literature review guidelines, this paper was written and searched
for relevant studies regarding autoantibodies and implantation, published in medical literature till 2020 were included in this review process. The search is done for studies
published till 2020 in the English language from the Medline database, including Google Scholar, PubMed, Web of Science and Cochrane library database.
Conclusions: Our recent work found that the involvement of APA, ANA and/or ATA in recipients of oocyte donations did not affect their pregnancy outcomes. Some researchers did not give any clear conclusion about these risks, and some stated that the use of some immunodepressant agents could be useful to reduce the harmful effects of these autoantibodies associated with implantation failure. Each autoantibody has a different mechanism of action to create the pathological state, some have direct effect, and some indirectly impact implantation. In future, further high-quality studies need to be performed for better understanding.
3 INDICATEURS CLÉS QUE LA GRANDE DISTRIBUTION DEVRAIT SURVEILLER POUR SATISFAIRE LE CONSOMMATEUR 5.0
Authors: Liu Jiayue , El Ghaldy Soukaina , Jupiter Adrien , Aufrere Thuy
Published: April 2021

En 2020, une des conséquences de la pandémie du coronavirus est l’accélération frappante de l’utilisation du digital dans notre vie quotidienne. Presque tous les secteurs d’activité ont dû revoir leur stratégie numérique, notamment la grande distribution. Celle-ci a dû s’adapter aux nouveaux comportements du “consommateur 5.0” qui, par obligation ou choix, se tournent de plus en plus vers la livraison ou le drive. Ce travail tente de montrer l’impact de 4 indicateurs (la saisonnalité, la pandémie, la mobilité, la météo) sur la demande en livraison et en drive afin de permettre à la grande distribution de répondre, d’ajuster et de prévoir la demande via le canal numérique.
COMMENT UTILISER L’INTELLIGENCE ARTIFICIELLE POUR PRÉDIRE LE REVENU PAR MILLE (RPM) DANS LA PUBLICITÉ DIGITALE ?
Authors: NGUYEN PHUONG
Published: April 2021

Dans le contexte où la recette des éditeurs en ligne dépend en large partie des revenus publicitaires, prévoir l’évolution du marché devient une tâche importante du Revenue Management. Dans ce cadre, les experts en analyse ont besoin des outils performants afin de réaliser des prévisions fiables sur lesquelles s’appuient les décisions stratégiques. L’analyse prédictive consiste à exploiter les données historiques et à dessiner ce qui va se passer à l’avenir avec une probabilité. Sur la base des données de Prisma Média, le leader de la presse magazine en France, nous comparons trois méthodes de l’apprentissage automatique les plus utilisées afin de prédire le RPM (ou revenu par mille) dans la publicité digitale.
Avaliação das Interações da Fauna de Formigas em Diferentes Usos do Solo
Authors: Do Amaral Gustavo Correiro , Vargas André Barbosa , Almeida Fabio Souto
Published: April 2021

O objetivo deste estudo foi avaliar as interações da fauna de formigas em uma floresta ombrófila densa, em um sistema agroflorestal diversificado, uma plantação de café sombreado por gliricídia e uma plantação de bananas que possuía vinhas de maracujá. Em cada um desses ambientes foram demarcados três transectos de 10m x 2m, onde as formigas foram coletadas e as interações ecológicas foram avaliadas. No total, foram observadas e coletadas 30 espécies de formigas, sendo a maior riqueza de espécies observada na agrofloresta, como, também, maior registro de interações. Já a menor riqueza e o menor registro de interações ocorreram no cafezal. Com base nos resultados do presente estudo, é possível constatar que, entre os sistemas de cultivo estudados, o sistema agroflorestal é o mais recomendado para a proteção da biodiversidade de formigas, por preservar maior número de espécies e de interações.
DAMPAK PEMUTUSAN HUBUNGAN KERJA SELAMA PANDEMI COVID-19 PERSPEKTIF HUKUM KETENAGAKERJAAN
Authors: Flambonita Suci
Published: April 2021

Research shows a wave of layoffs and a decrease in labor/employee/employee income during the COVID-19 pandemic. The percentage of dismissed workers/employees/employees in Indonesia at the end of April 2020 was 15.6%. Based on data obtained by the South Sumatra Regional Office of Manpower and Transmigration on April 29, 2020, as many as 612 workers in South Sumatra experienced layoffs due to the COVID-19 pandemic. A total of 7,020 workers were laid off and received no wages during the pandemic. The research method used is socio legal research, namely research that examines the social symptoms that exist in society and then correlates them with statutory regulations. The impact of layoffs during this pandemic, many of these companies often use force majeure reasons. On the other hand, to tackle the Covid-19 problem, one of the efforts made by the Government is the Circular of the Minister of Manpower Number M/3/HK04/II/2020 concerning Protection of Workers/Laborers and Business Continuity in the Context of Preventing and Overcoming Covid-19. Some companies that cut off work relations during the COVID-19 pandemic often use force majeure reasons, to avoid wages and severance pay that should be the rights of workers/laborers.
Sistema electoral ecuatoriano, ¿concentrador o proporcional?: una aproximación crítica a las reformas del 2019-2020
Authors: Garzón Sherdek Karen Andrea , Cahuasquí Cevallos Santiago Manuel
Published: April 2021

Este artículo analiza las reformas al Código de la Democracia vigentes desde el 3 de febrero de 2020 y su impacto en la reconfiguración del sistema electoral ecuatoriano. Se intenta determinar si la implementación del método Webster para elecciones locales constituye o no un cambio respecto a la proporcionalidad del sistema electoral o, por el contrario, reproducen un marco normativo concentrador y excluyente. Se analizan tres de los elementos que conforman el sistema electoral y que fueron motivo de la reforma: forma de candidatura, forma de voto y fórmula de adjudicación de escaños que se problematizarán a la luz del tipo de circunscripción electoral vigente. Autores como Freidenberg (2010) y Pachano (2010) han señalado que la heterogeneidad es una característica central del sistema electoral ecuatoriano, acentuado por un proceso de constantes reformas de distinto tipo y profundidad. Sin embargo, esta particularidad, que no representa per se un inconveniente en términos de la obtención de resultados de un proceso eleccionario, sí tiene incidencia directa en el sistema de partidos, la representación política, y, por tanto, en la eficiencia de la democracia representativa.
La creciente polarización ideológica en Ecuador bajo el Gobierno de Rafael Correa
Authors: Moncagatta Paolo , Poveda Ana Emilia
Published: April 2021

El artículo presenta un análisis descriptivo del proceso de polarización ideológica ocurrido en Ecuador durante la década de gobierno de Rafael Correa. A partir de datos de las encuestas Barómetro de las Américas del Latin American Public Opinion Project (Lapop), se propone una medición de polarización ideológica basada en el autoposicionamiento de los ciudadanos en la escala ideológica izquierda-derecha. A partir del indicador propuesto, se realiza un análisis de la evolución de los niveles de polarización ideológica encontrados en la ciudadanía ecuatoriana desde antes de la llegada de Correa al poder, hasta dos años después de terminado su mandato. Entre los principales hallazgos, se encuentra un gradual incremento en el indicador de polarización, que llega a su nivel máximo en 2016, así como un aumento en la autoidentificación ideológica de los ciudadanos, que ocurre tanto con la izquierda como con la derecha. Para finalizar, se discute de forma breve las posibles consecuencias de la creciente polarización ideológica en términos generales y para Ecuador en particular.
Migración venezolana y discriminación en Ecuador durante el 2019: análisis del encuadre informativo en Teleamazonas y El Universo
Authors: Ynciarte González Luis Eduardo
Published: April 2021

Este artículo viene de una investigación en curso y analiza los contenidos noticiosos que generaron dos medios de comunicación respecto de la migración de personas venezolanas hacia Ecuador durante el año 2019. Se argumenta que los medios influyen en la percepción de sus receptores, para ello se enfatiza en dos teorías de la comunicación: 1) el establecimiento de la agenda, que explica la manera en la que los medios seleccionan y jerarquizan las noticias del día y 2) el encuadre informativo que los medios le otorgan a los contenidos noticiosos. En este análisis se hará uso de 256 noticias difundidas en las plataformas digitales de dos medios ecuatorianos: Teleamazonas.com y Eluniverso.com. Este estudio considera que ambos medios de comunicación, al decodificar y tomar posición frente a las noticias y hechos que muestran, generan discriminación y xenofobia en comunidades ecuatorianas.
Democracia y cultura política en América Latina
Authors: Paredes Ana Marcela , Cordero Ponce Sofía
Published: April 2021

El Tema central de esta revista fue concebido a finales del año 2019. El objetivo de la convocatoria fue identificar características que distingan a las democracias y la cultura política latinoamericana en estas dos últimas décadas.
Investigasi Sikap Sosial Yang Dimiliki Oleh Siswa Kelas Xi Di SMAN 3 Kota Jambi Pada Mata Pelajaran Fisika
Authors: Murniati  , Erika
Published: April 2021

Tujuan penelitian: Adapun tujuan dari penelitian ini untuk mengetahui deskripsi sikap sosial yang dimiliki oleh siswa kelas XI di SMAN 3 Kota Jambi. Untuk mengetahui kendala dalam pengembangan sikap sosial yang dimiliki oleh siswa kelas XI di SMAN 3 Kota Jambi. Metodologi: Penelitian ini termasuk kedalam penelitian campuran (mix method). Data kualitatif didapatkan menggunakan lembar instrument wawancara. Sedangkan untuk data kuantitatif diperolah dengan menggunakan metode survey dan teknik pengumpulan data berupa angket. Temuan utama: Hasil dari penelitian ini menunjukkan bahwa 46.% peserta didik memiliki sikap jujur yang baik, 63.3% memiliki sikap disiplin yang sangat baik, 53.3% telah memiliki sikap tanggung jawab yang sangat baik, 53.3% telah memiliki sikap santun yang baik, 50% memiliki sikap peduli yang baik, dan 36.6% memiliki sikap percaya diri yang cukup baik. Keterbaruan penelitian: Keterbaruan dari penelitian ini yaitu idikator yang digunakan untuk melihat sikap sosial peserta didik pada pembelajaran fisika.
Culture and Motives of Tourists on Food Consumption in Hong Kong
Authors: Lee Derrick , Baldwin Watson , Chan Wilco , Shih Erin Hui-Wen
Published: April 2021

This article analyzed the motivational dimensions of tourists in Hong Kong. The study identified eight motivational dimensions of food consumption of Chinese tourists and Western tourists. The study revealed both groups of tourists shared similar motives, such as service and assurance,
food and knowledge, authentic and culture, interpersonal and price, and familiarity and eating habit. However, the Chinese and Western tourists have different emphasis on food consumption in terms of value, variety, prestige, and ambience. The differences can be associated to cultural factor.
Findings are useful to decision makers and marketers in promoting Hong Kong as a leading food tourism destination.
EXPERIENCE OF APPLYING LIPOPHILIC OINTMENT "WUNDAHYL" WHEN TREATING SUPERFICIAL BURNS
Authors: Kravtsov O. V. , Shapoval O. V. , Isaev Yu. I. , Tsohoev A. A. , Kurbanov Teimur Ahaliievich
Published: April 2021

For the local treatment of burns, numerous drugs have been proposed with a tendency to expand the range of drugs. In order to establish the effectiveness of Wundehil ointment in the treatment of superficial burns and to determine the optimal methods of its application, the results obtained in the patients with second−grade burns were analyzed. Clinical evaluation of treatment was performed on the basis of visual control of the wound process, determination of the amount and nature of exudate, the timing of epithelialization of superficial burns. The dynamics of the wound process was observed by cytological examination. In the preparations, which were examined by immersion microscopy, the cell composition was studied to determine the type of cytogram according to the generally accepted classification. The type of cytogram in the patients was characterized as inflammatory. Among the cell elements in the smear, segmental neutrophilic granulocytes, monocytes in small numbers, and single lymphocytes predominated. Signs of phagocytic activity were recorded, and neutrophilic granulocytes with intracellular arrangement of microorganisms were detected. On the 7th day after the injury, the inflammatory type of cytogram was recorded in smears−imprints in 3 patients, inflammatory−regenerative were found in 6, regenerative ones were revealed in 14. On the 10th day only 2 patients had an inflammatory−regenerative type of cytogram. The obtained data indicate that the "Wundehyl" drug on a lipophilic basis with the content of components of natural origin meets the requirements for a local treatment of burns. The use of this ointment in patients with second−degree burns reduces the severity of the inflammatory reaction, has a stimulating effect on reparative processes in the burn wound, prevents mechanical damage during dressings and reduces the duration of epithelialization in second−grade burns.

Key words: burns, local treatment, cytological examinations, "Wundahyl" ointment.