bluuebunny/crossref_metadata_2025 huggingface dataset:
Bollnow leitor de Heidegger e de Binswanger
Authors: Borges Duarte Irene
Published: September 2022

Em 1945, Otto Friedrich Bollnow publica uma recensão da obra fundamental de Ludwig Binswanger, aparecida em 1942, em que procura desenvolver uma concepção antropológica, tomando como ponto de partida e fundamento a Ontologia Fundamental de Martin Heidegger, tal como fora exposta em 1927, em Ser e Tempo. O presente trabalho consiste na tradução e apresentação desse texto de Bollnow, enquadrando-as numa hermenêutica da existência, desenvolvida por este autor ao longo da sua obra, e na tematização, por ambos os autores, das tonalidades afectivas positivas, muito especialmente como o amor em Binswanger.
EDITORIAL Dossier: I Paraná Meeting of Studies on Heidegger (Toledo – Unioeste, 2019)
Authors: Cardoso Libanio , Santini Guilherme José
Published: September 2022

Editorial Inglês
Dialeto e linguagem em Hebel e Heidegger
Authors: Aurélio Werle Marco
Published: September 2022

Pretende-se examinar a interpretação que Heidegger realiza de Hebel, um poeta e escritor decalendários que escrevia em dialeto e, portanto, colocou em questão o sentido da língua e dalinguagem como morada humana no mundo.
La alteración ontológica de nuestro mundo. Consideraciones desde existenciales heideggerianos
Authors: Loyola Rudyard
Published: September 2022

En este trabajo se busca mostrar lo que hemos llamado el fenómeno de “la alteración ontológica denuestro mundo”. Para ello fijaremos la mirada en la memoria de la destrucción dejada por elterremoto-maremoto en la ciudad de Coquimbo (Chile) del 16 de septiembre de 2015. Trataremos deiluminar esta experiencia basándonos en existenciales heideggerianos tales como: el mundo, elcoestar, la coexistencia y otros conceptos relacionados. Es la alteración de la significatividad de estehorizonte que es el mundo el que nos hace percibir los entes, las personas, la sociedad, el tiempo y latotalidad de las cosas de manera distinta. Esta explicación que parece bastante obvia posee detrás unarica dinámica que tiene que ver con nuestro estar-en-el-mundo.
A intencionalidade do autor, segundo Paul Ricouer
Authors: Canuto de Barros Leonardo
Published: September 2022

O trabalho investiga em que medida a intencionalidade do autor, oculta no texto, deve ser perscrutada pelo leitor ao interpretar, tendo em vista que, na ausência do autor durante o ato de leitura, a intenção do próprio texto se sobrepõe à do autor. Para tanto, recorreremos, principalmente, a passagens de duas obras de Paul Ricoeur, Do texto à ação e Tempo e narrativa.
A Natureza e o infinito: Merleau-Ponty leitor de Descartes
Authors: de Campos Moura Alex
Published: September 2022

Nossa proposta neste ensaio é descrever a primeira problematização apresentada por Merleau-Ponty a respeito da noção de Natureza em seus cursos ministrados no Collège de France,defendendo a hipótese de que ele a constrói, em grande medida, através de um diálogo e de umainterpretação particular do pensamento cartesiano. Procuraremos mostrar que Merleau-Pontyreconhece em Descartes a permanência de uma ontologia implícita ou latente – coexistente com suaontologia “oficial” –, que “resiste” à formulação puramente inteligível da ideia de Natureza, e que,por isso mesmo, preserva para ela o campo da existência e da realidade.
PERETTI, Clélia. Nas trilhas de Edith Stein: gênero em perspectiva fenomenológica e teológica. Curitiba: Appris, 2019. 323p.
Authors: Pegoraro Evandro
Published: September 2022

Publicou-se pela editora Appris no ano de 2019 o livro Nas trilhas de Edith Stein:gênero em perspectiva fenomenológica e teológica, da pesquisadora Clélia Peretti,professora do curso de Bacharelado em Teologia e do Programa de Pós-Graduação(Mestrado e Doutorado) em Teologia da PUCPR. Resultado do seu doutorado, o livropossui como tema as contribuições nos campos da filosofia e da teologia na perspectivafeminina a partir da filósofa e mística Edith Stein, uma das grandes mulheres do séculoXX. Escrito por uma mulher sobre uma das grandes mulheres do século XX, um dosseus méritos consiste no fato de assumir a defesa da feminilidade à luz da fé.Prefaciado pelo professor, pesquisador e tradutor Renato Kirchner e apresentado peloprofessor Ezequiel Westphal, o livro está dividido em cinco capítulos.
A Scale Project Showing How Mangrove Forests Protect the Coast from Wave Erosion
Authors: Md. Azam  , K. Yellaraju  , P. Renuka  , Vayuraj  , Ravali
Published: September 2022

Mangrove forests are generally found along sheltered coasts where they grow abundantly in saline soil and brackish water subject to periodic fresh and salt water inundation. Undoubtedly the mangrove forest is a very dynamic and highly productive ecosystem. It not only plays multiple ecological functions essential to its surrounding habitats, but it is also an important resource for the coastal communities. However, there are some issues that threatened the existence of the mangrove ecosystem. Unfortunately, human activities are one of the main factors which contribute to the degradation of mangrove forest. Due to the importance of the mangrove ecosystem and the issues that might endanger the life of mangroves, it is necessary to protect the mangrove forest by having a good management system. This paper contains the literature review that will help to give a better understanding about the importance of the mangrove forest ecosystem and also the background of mangrove forest management. There are two countries that have been selected for the case study of mangrove forest management which are Malaysia and Thailand. Therefore, this paper highlights the main importance of managing mangrove forest in preserving the ecosystem and provided with the recommendation in the last chapter.
Experimental Study on Eco-Friendly Green Cement With Partial Replacement of Cement with Flyash, GGBS and Granite
Authors: B. Harish  , P. Raghupathi  , S. Manasa  , Bharath  , R. Soumya Sree
Published: September 2022

Concrete is considered as a strong and durable construction material lasting over a century. Reinforced concrete is one among the most popular materials used for construction around the world. reinforced concrete is subjected to deterioration in harsh environment like costal regions therefore, sereveral researchers are striving hard with their efforts towards developing a new material to overcome this problem. This research investigates the utilization of marble dust powder in concrete, where marble A Green cement is a revolutionary topic in the history of cement Industry. This was first invented in Denmark in the year 1998.It presents the feasibility of the usage of By product materials like Flyash, GGBS(Ground granulated blast furnance slag),Graintedust. The use of Flyash in cement contributes the reduction of green house emission with negative impacts on the economy .It has been observed that 0.9tons of CO2 is produced per ton of cement production. It accounts for around 5% of world’s CO2 emission. it avoids the pollution and resue the materials the present study is carried out. Green cement reduces the shrinkage, creep, less heat of hydration and better workability and it requires less energy for its production ,Green cement is used in construction of bridges, buildings, dams and roads.
Intelligent Traffic Monitoring System
Authors: Manohara A B  , Deepa KR
Published: September 2022

The increased popularity of private automobile has result in more congested urban traffic. As a result, traffic has become one of the most serious issues in major cities throughout the globe. Congestion and accidents are two major traffic challenges, both of which have resulted in significant time loss, property damage, and pollution. This project entails the development and deployment of a computer vision and image processing-based intelligent and automated traffic control system. This technology recognizes the number of cars on each route and assigns an optimal amount of waiting time based on the the amount more cars on every route. This system is entirely automated and may be used to replace the traditional, dynamically regulated transportation system with a fixed-time transportation system. The planned method has the potential to significantly reduce traffic congestion in congested cities via preserving it considerable number of person time that would otherwise be wasted waiting on congested highways. This research focuses, low-cost image analysis, and load balancing.
Deep Learning Model for Financial Time Series Prediction
Authors: Mr. B V Pranay Kumar  , Mr. Avaniketh P  , Mr. A. Poorna Chandra Reddy  , Ms. Mallika K. P  , Mr. Morigadi Aravind
Published: September 2022

Stock market is considered complex, fickle, and dynamic. Undoubtedly, prediction of its price is one of the most challenging tasks in time series forecasting. Traditionally, there are several techniques to effectively predict the next t lag of time series data such as Logistic Regression and Random Forest. With the recent progression in sophisticated machine learning approaches such as deep learning, new algorithms are developed to analyze and forecast time series data. This paper employs Long-Short Term Memory (LSTM) deep learning approach to predict future prices for low, medium, and high risk stocks. To the best of our knowledge, we are proposing an innovating technique to evaluate deep learning and other prediction techniques w.r.t. the stocks’ risk factor. The proposed approach is compared with other traditional algorithms over different periods of training data. The results show that our LSTM approach outperforms other traditional approaches for all stock categories over different time periods. Experimental results illustrate that, for low and medium risk stocks, it is better to use LSTM with long time period of training data. However, for high risk stocks, short time period of training data provides more accurate predictions.
Analysis of the Impact of Electric Vehicle Charging Station on Power Quality Issues
Authors: K. Kumaraswamy  , O. Mohan  , Ch. Muarali  , Ch. Manisha  , B. Sangeetha
Published: September 2022

Although, number of Electric Vehicles (EV) in Bangladesh are limited compared to conventional vehicles but in near future, expecting that the EV penetration will be increased significantly. Owing to environmental & socio-economic benefits with reduction of fossil fuel use, EV markets are expanding. These EV have a major impact on the power gird & distribution networks and due to the consequences of huge power demand to recharge their batteries. Large number of EV charging station when integrates with the utility grid, it produces harmonics, affect the voltage profile, finally affects the power quality. In this paper, the impact of electric vehicle charging station in Bangladesh on power grid and distribution networks is analyzed in terms of power demand, harmonics, Voltage sag & swelling and transformer power loss. Also, the mitigation technique for reducing power quality disturbances is analyzed in this paper.
Study on Self Compacting Geopolynmer Concrete
Authors: T. Naresh  , Dr. G. Madhavarao  , Ch. Geetha  , Krishna Sree  , Mounika
Published: September 2022

Self-compacting concrete (SCC) became a strong candidate for various construction applications owing to its excellent workability, low labor demand, and enhanced finish-ability, and because it provides a solution to the problem of mechanical vibration and related noise pollution in urban settings. However, the production of Portland cement (PC) as a primary constituent of SCC is energy-intensive, contributing to about 7% of global carbon dioxide (CO2 emissions. Conversely, the use of alternative geopolymer binders (GBs) in concrete can significantly reduce the energy consumption and CO2 emissions. In addition, using GBs in SCC can produce unique sustainable concrete with unparallel engineering properties. In this outlook, this work investigated the development of some eco-efficient self-compacting geopolymer concretes (SCGCs) obtained by incorporating different dosages of fly ash (FA) and ground blast furnace slag (GBFS). The structural, morphological, and mechanical traits of these SCGCs were examined via non-destructive tests like X-ray diffraction (XRD) and scanning electron microscopy (SEM). The workability and mechanical properties of six SCGC mixtures were examined using various measurements, and the obtained results were analyzed and discussed. Furthermore, an optimized hybrid artificial neural network (ANN) coupled with a metaheuristic Bat optimization algorithm was developed to estimate the compressive strength (CS) of these SCGCs. The results demonstrated that it is possible to achieve appropriate workability and mechanical strength through 50% partial replacement of GBFS with FA in the SCGC precursor binder. It is established that the proposed Bat-ANN model can offer an effective intelligent method for estimating the mechanical properties of various SCGC mixtures with superior reliability and accuracy via preventing the need for laborious, costly, and time-consuming laboratory trial batches that are responsible for substantial materials wastage.
Design and Control of Micro-Grid fed by Renewable Energy Generating Sources
Authors: Dr. Veeru  , P. Prabhakar  , E. Renuka  , Md. Amzad  , M. Srilekha  , B. Sandhya
Published: September 2022

This paper presents a control of a micro-grid at an isolated location fed from wind and solar based hybrid energy sources. The machine used for wind energy conversion is doubly fed induction generator (DFIG) and a battery bank is connected to a common DC bus of them. A solar photovoltaic (PV) array is used to convert solar power, which is evacuated at the common DC bus of DFIG using a DC-DC boost converter in a cost effective way. The voltage and frequency are controlled through an indirect vector control of the line side converter, which is incorporated with droop characteristics. It alters the frequency set point based on the energy level of the battery, which slows down over charging or discharging of the battery. The system is also able to work when wind power source is unavailable. Both wind and solar energy blocks, have maximum power point tracking (MPPT) in their control algorithm. The system is designed for complete automatic operation taking consideration of all the practical conditions. The system is also provided with a provision of external power support for the battery charging without any additional requirement. A simulation model of system is developed in Matlab environment and simulation results are presented for various conditions e.g. unviability of wind or solar energies, unbalanced and nonlinear loads, low state of charge of the battery. Finally a prototype of the system is implemented using a 5 kW solar PV array simulator and a 3.7 kW wound rotor induction machine and experimental results are produced to reaffirm the theoretical model and design.
A User Centric Machine Learning Framework for Cyber Security Operation Center
Authors: Mr. M Ramaraju  , Dr. Ch. Srinivas Rao  , Mr. J Purna Prakash  , Challa Sruthi  , Gadala Akhil
Published: September 2022

In order to ensure a company's Internet security, SIEM (Security Information and Event Management) system is in place to simplify the various preventive technologies and flag alerts for security events. Inspectors (SOC) investigate warnings to determine if this is true or not. However, the number of warnings in general is wrong with the majority and is more than the ability of SCO to handle all awareness, because of this, malicious possibility. Attacks and compromised hosts may be wrong. Machine learning is a possible approach to improving the wrong positive rate and improving the productivity of SOC analysts. In this article, we create a user-centric engineer learning framework for the Internet Safety Functional Center in the real organizational context. We discuss regular data sources in SOC, their workflow, and how to process this data and create an effective machine learning system. This article is a immediate two groups of readers. The first group is intelligent researchers who have no knowledge of data scientists or computer safety fields but who engineer should develop machine learning Systems for machine safety. The second groups of visitors are Internet security practitioners that have deep knowledge and expertise in Cyber Security, but do Machine learning experiences do not exist and I'd like to create one by themselves. At the end of the paper, we use the account as an example to demonstrate full steps from data collection, label creation, feature engineering, machine learning algorithm and sample performance evaluations using the computer built in the SOC production of Seyondike
Deep Learning Model for Financial Time Series Prediction
Authors: CH. Srinivas Reddy  , K. Mamatha  , N. Umarani  , G. Komala
Published: September 2022

Stock market is considered complex, fickle, and dynamic. Undoubtedly, prediction of its price is one of the most challenging tasks in time series forecasting. Traditionally, there are several techniques to effectively predict the next t lag of time series data such as Logistic Regression and Random Forest. With the recent progression in sophisticated machine learning approaches such as deep learning, new algorithms are developed to analyze and forecast time series data. This paper employs Long-Short Term Memory (LSTM) deep learning approach to predict future prices for low, medium, and high risk stocks. To the best of our knowledge, we are proposing an innovating technique to evaluate deep learning and other prediction techniques w.r.t. the stocks’ risk factor. The proposed approach is compared with other traditional algorithms over different periods of training data. The results show that our LSTM approach outperforms other traditional approaches for all stock categories over different time periods. Experimental results illustrate that, for low and medium risk stocks, it is better to use LSTM with long time period of training data. However, for high risk stocks, short time period of training data provides more accurate predictions.
Influence of laboratory-controlled ethanolic wheatgrass extract on acetic acid-induced changes in biochemical and antioxidant indices in the colitis of Wistar rats
Authors: Susan Oommen Sainu , Fernandes Hilda , Holla Rajendra
Published: September 2022

Introduction and Aim: Triticum aestivum (wheatgrass) is a good source of mineral nutrients and antioxidant enzymes. It also acts as a detoxifying agent and helps to revive healthy cells. The present study aimed to assess the effects of acetic acid on biochemical and antioxidant indices in the colitis of Wistar rats using an ethanolic extract derived from the dried shoots of wheatgrass maintained under specified growth conditions.

 

Materials and Methods: Aqueous and ethanolic extract of wheatgrass was subjected to preliminary phytochemical screening and in-vitro antioxidant activity. Effects of the ethanolic wheatgrass extract were investigated in the acetic acid-induced rat colitis model. Sulphasalazine was used as the standard anti-inflammatory drug. Malondialdehyde (MDA), myeloperoxidase (MPO), total antioxidant capacity (TAC), catalase (CAT), and reduced glutathione (GSH) levels were estimated in the rat blood. Colitis was quantified with a clinical score and colon length/weight index was measured. Histopathological analyses were also performed on the colon tissue of rats.

 

Results: The presence of phytochemical elements such as saponins, tannins, alkaloids, and terpenes in aqueous and ethanolic wheatgrass extract was discovered. These compounds have the potential to boost antioxidant and anti-inflammatory effects. The ethanolic extract significantly reduced MDA, MPO, and antioxidant levels (TAC, CAT, and GSH) in colon tissue and blood. Biochemical measurements corroborated the conclusions of histopathological investigation.

 

Conclusion: According to macroscopic, microscopic, histological, and other biochemical studies, ethanolic wheatgrass extract significantly inhibits experimental colitis in rats.
E-procurement for destination management companies within the tourism industry in South Africa : digital era trends, challenges and responses
Authors:   , Berndt Lucy
Published: September 2022

The study attempted to identify digital era Information Communication Technologies (ICTs) that suppliers used, and the challenges, responses, and trends they generated for e-procurement in Destination Management Companies (DMCs). The objectives were to analyse e-procurement in DMCs, through suppliers using ICTs, whilst concentrating on the elements from the new economy through investigation and evaluation; to predict new phenomena in this ever-changing field; and lastly, assessing the challenges that DMCs experienced because of suppliers using ICTs, with possible solutions or recommendations for procurement. Qualitative methodologies were used in order to observe various ICTs in the Tourism Distribution Channel (TDC). The population consisted of eight suppliers, representing over 135 different products and services, each differing from one another in terms of regions they cover, representation, and size. Seven DMCs ranging in size, in various locations and operating or specialising in different markets were selected for the research. To accomplish the objectives, questionnaires, and telephonic discussions with Revenue Managers, Contract Managers or International Sales Managers were conducted. The methodology is based on internal validity as the researcher is close to reality, spending large amounts of time in the field and having collected multiple data and therefore the gaps have been reduced. Reliability of the study can be tested through triangulation as different sources have been used to build a coherent justification. The results show that there is still much to be done before the successful implementation of eprocurement.
The Concept of Development of Ex-Mining C Mine in Wonosobo Regency
Authors: Masrurun Zam Zam , Ulfa Wilda Rizkina
Published: September 2022

The development of ex-mining land needs to be carried out to preserve the environment and make an alternative to sustainable, beneficial, and efficient use of ex-mining land. This study aims to provide an alternative concept for the development of ex-mining C excavation in Kertek District and Mojotengah District in Wonosobo Regency so that ex-mining land can still have economic value but is sustainable from the physical and environmental aspects. This research used a SWOT analysis technique. Data analysis was carried out from the results of collecting field facts and secondary data to identify existing conditions and ideal conditions to be achieved, as well as through alternative studies by identifying and analyzing segmentation based on land use, location, and existing conditions. The results of the study resulted in the concept of Eco-community Highland Tourism. This concept is to develop an area with high environmental quality and human resources, driven by the tourism sector as a priority. This concept contains the principles of improving environmental quality, economic sustainability, community empowerment, and the development of the tourism sector by the upland agricultural sector.
Tingkat Pengetahuan Masyarakat Tentang DAGUSIBU (Dapatkan Gunakan Simpan Buang) Obat di Dusun Kerembong Timur Tahun 2021
Authors: Oktaviani Nur , Sidrotullah M. , Alfaiza Nora
Published: September 2022

Pengetahuan merupakan suatu hasil dari rasa keingin tahuan melalui proses sensoris, terutama pada mata dan telinga terhadap objek tertentu. Perlu adanya pengawasan dan penyampaian informasi tentang obat untuk masyarakat dalam mendapatkan, menggunakan, menyimpan serta membuang obat dengan baik, dalam dunia kesehatan dikenal dengan DAGUSIBU (Dapatkan, Gunakan, Simpan, Buang) Obat. Tujuan dari penelitian ini adalah untuk menngetahui tingkat pengetahuan masyarakat tentang Dagusibu Obat di Dusun Kerembong Timur.

Jenis penelitian adalah penelitian deskriptif. Populasi dari penelitian yaitu masyarakat yang berdomisili di Dusun Kerembong Timur Sampel yang digunakan berjumlah 100 orang. Teknik pengambilan sampel menggunakan purposive sampling.

Hasil penelitian menunjukkaan bahwa tingkat pengetahuan masyarakat tentang Dagusibu Obat Dusun Kerembong Timur yang berpengetahuan kurang berjumlah 17 responden, pengetahuan cukup berjumlah 51 responden dan pengetahuan baik berjumlah 32 responden.

Sehingga dapat disimpulkan Distribusi tingkat pengetahuan tentang DAGUSIBU Obat di Dusun Kerembong Timur mendapatkan hasil pengetahuan baik sebesar (32%), Pengetahuan cukup sebesar (51%), Pengetahuan kurang sebesar (17%).tingkat pengetahuan cukup tentang Dagusibu Obat. Bagi masyarakat diharapkan untuk lebih teliti dalam mendapatkan, menggunakan, menyimpan, terutama dalam membuang obat dengan benar, agar tidak terjadi hal yamg tidak diinginkan. Apabila ada kekeliruan atau ketidak tahuan dalam hal yang berkaitan tentang DAGUSIBU Obat untuk menanyakan kepada Apoteker atau petugas Farmasi terdekat.
Tasavvufta Sembolizme Tipik Bir Örnek: Ken’ân Rifâî’nin „Rifâî Mihrâbı“ Tasvîri
Authors: Güldütuna Hatice Dilek
Published: September 2022

Sûfîlerin metafizik alandaki soyut mânâları zihnî seviyeye ve fizikî âleme yaklaştırmada sıklıkla sembollere müracaat ettikleri, metaforları bazen bu gaybî alanı açmak, bazen de örtmek gâyesiyle kullandıkları bilinmektedir.
Bu makalenin konusunu teşkil eden ve Şeyh Ken’ân Rifâî’ye âit Seyyid Ahmed er-Rifâî eserinin kapağına konulmak üzere hazırlanan Rifâî Mihrâbı tasvîri, hem derviş çeyizi olarak adlandırılan tarikat unsurlarını, hem de mânevî yolun derecelerine ve kâmil insanın mâhiyetine dâir zengin sembolleri içermesi sebebiyle tasavvufta sembol kullanımına tipik bir örnektir. Mihrâb resminde sembollerle ifade edilen hakikatlerin daha rahat anlaşılması için Ken’ân Rifâî’nin halifesi Ziyâ Cemâl Bey tarafından hazırlanan “Mihrâb ve Zarfın Tefsîri” başlıklı yazı, tasvirin yorumlanmasında ilk başvurulan kaynak olmuştur.
Tasvîr, tekkelerin semâhane kısmında yer alan mihrâbın ve çevresinde yer alan unsurların anlamını, Ahmed er-Rifâî’nin kutup ve gavs makamlarının sâhibi bulunduğunu, tasavvuf ve tarîkatlerin gâyesinin nefsin tekâmül ederek insanın irfâna, kemâle ve güzel ahlâka erişmesi olduğunu, nefis ile mücâdelenin mâhiyetini ve mertebelerini ve bu yolculukta kâmil insana olan ihtiyacı sembolik bir anlatımla gözler önüne sermektedir.
Review on hadith and hadith didactics by Yaşar Sarıkaya Verlag Ferdinand Schöningh. Paderborn 2021. 290 pages
Authors: Üce Muammer
Published: September 2022

Diese Rezension zielt darauf ab, das Buch Hadith und Hadithdidaktik von Prof. Yaşar Sarıkaya zu analysieren. Das Buch füllt eine große Lücke, um Menschen für die Arbeit mit Ahadith zu sensibilisieren. Das Buch ist in zwei große Kapitel unterteilt: Hadithwissenschaft und Hadithdidaktik. In Seinem Buch stellt Der Autor folgende didaktische Kriterien für die Arbeit mit den Hadithen auf: Elementarisierung, Diskursivität, Kontextbezogenheit, Korrelation oder Bezug zur Lebenswirklichkeit und Orientierungshilfe versus Normativität. Zusammenfassend kann das Buch neue Impulse für die islamische Fachdidaktik anbieten und Wissenschaftler und Lehrkräfte motivieren sowohl im theoretischen und besonders im (unterrichts-)praktischen Bereich „neue Ufer“ zu erkunden, um eine nachhaltige Fachlichkeit - im Sinne einer inhaltlichen Breite und theologischen Tiefe- zu fördern.
Response to Letter to Editor From the Canadian Stroke Consortium
Authors: Dunfield Lesley
Published: September 2022

We thank the Canadian Stroke Consortium Policy and Advocacy Committee for its Letter to the Editor regarding the Rapid Review on Systemic Thrombolysis by Alteplase for Acute Ischemic Stroke.

Many of the concerns raised were related to the limitations of the methods and processes used for CADTH Rapid Reviews, which use abbreviated systematic review methods to complete syntheses in accelerated time frames.

While care is taken to ensure the work is complete and up to date within Rapid Review methods and processes, Rapid Reviews are not comprehensive systematic reviews and are not intended to be used as substitutes for clinical or professional judgment.
Dostarlimab (Jemperli)
Authors: CADTH
Published: September 2022

CADTH recommends that Jemperli should not be reimbursed by public drug plans for monotherapy for the treatment of adult patients with mismatch repair deficient (dMMR) or microsatellite instability-high (MSI-H) recurrent or advanced endometrial cancer (EC) that has progressed on or following prior treatment with a platinum-containing regimen.

While evidence from a clinical trial demonstrated that some patients had disease that responded during treatment with Jemperli, without a control group there is uncertainty in how much the observed responses were due to Jemperli treatment rather than chance.

There was too much uncertainty in the reviewed evidence to determine how Jemperli compares to other treatments used in Canada.

It is unclear whether Jemperli meets the following needs identified by patients: improved tumour response, delayed disease progression, improved quality of life, and fewer side effects.
Avalglucosidase Alfa (Nexviazyme)
Authors: CADTH
Published: September 2022

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.

The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.

This review assesses Avalglucosidase alfa (Nexviazyme), 100 mg/vial, 20 mg/kg of body weight, administered every other week by IV infusion.

Indication: Nexviazyme (avalglucosidase alfa) is an enzyme-replacement therapy indicated for the long-term treatment of patients with late-onset Pompe disease (LOPD) (acid alpha-glucosidase deficiency).
Delegation Of Medical Tasks And Delivery Of Information By Doctors To Nurses Based On Law Number 38 Of 2014 Concerning Nursing
Authors: Febriadi Herry
Published: September 2022

Delegation is the delegation of authority in the process of transferring duties and responsibilities given by doctors to nurses, program implementers, or services to carry out certain tasks within a certain time. Legal actions in the medical world are carried out with the delegation of authority and informed consent in the provision of health care. Health is a human right that is recognized and protected by the 1945 Constitution of the Republic of Indonesia.
Based on the results of the study, it is understood that the application of the law regarding the legal force of delegation of authority and informed consent must be carried out correctly following the Standard Operating Procedures (SOP) that have been established. there are, in addition, medical and non-medical already know and understand the rules and consequences of the actions to be taken in connection with the delegation of authority and the provision of informed consent.
Impacts of condensable particulate matter on atmospheric organic aerosols and fine particulate matter (PM2.5) in China
Authors: Li Mengying , Yu Shaocai , Chen Xue , Li Zhen , Zhang Yibo , Song Zhe , Liu Weiping , Li Pengfei , Zhang Xiaoye , Zhang Meigen , Sun Yele , Liu Zirui , Sun Caiping , Jiang Jingkun , Wang Shuxiao , Murphy Benjamin N. , Alapaty Kiran , Mathur Rohit , Rosenfeld Daniel , Seinfeld John H.
Published: September 2022

Abstract. Condensable particulate matter (CPM) emitted from stationary combustion and
mobile sources exhibits high emissions and a large proportion of organic
components. However, CPM is not generally measured when conducting emission
surveys of PM in most countries, including China. Consequently, previous
emission inventories have not included emission rates for CPM. Here, we
construct an emission inventory of CPM in China with a focus on organic
aerosols (OAs) based on collected CPM emission information. Results show that
OA emissions are enhanced twofold after the inclusion of CPM in a new
inventory for China for the years 2014 and 2017. Considering organic CPM emissions and
model representations of secondary OA (SOA) formation from CPM, a
series of sensitivity cases have been simulated here using the three-dimensional
Community Multiscale Air Quality (CMAQ) model to estimate the contributions
of CPM emissions to atmospheric OA and fine PM (PM2.5, particulate matter with
aerodynamic diameter not exceeding 2.5 µm) concentrations
in China. Compared with observations at a Beijing site during a haze episode from 14 October
to 14 November 2014, estimates of the temporal average
primary OA (POA) and SOA concentrations were greatly improved after including
the CPM effects. These scenarios demonstrated the significant contributions
of CPM emissions from stationary combustion and mobile sources to the POA (51 %–85 %​​​​​​​), SOA (42 %–58 %), and total OA
concentrations (45 %–75 %). Furthermore, the contributions of
CPM emissions to total OA concentrations were demonstrated over the 2 major
cities and 26 other cities of the Beijing–Tianjin–Hebei region (hereafter referred to as the “BTH2 + 26 cities”) in December 2018, with average contributions of up to 49 %, 53 %, 54 %, and 50 %
for Handan, Shijiazhuang, Xingtai, and Dezhou, respectively.
Correspondingly, the inclusion of CPM emissions also narrowed the gap
between simulated and observed PM2.5 concentrations over the BTH2 + 26
cities. These results improve the simulation performance of atmospheric OA
and PM2.5 and may also provide important implications for the sources of
OA.
Using a process-based dendroclimatic proxy system model in a data assimilation framework: a test case in the Southern Hemisphere over the past centuries
Authors: Rezsöhazy Jeanne , Dalaiden Quentin , Klein François , Goosse Hugues , Guiot Joël
Published: September 2022

Abstract. Currently available data-assimilation-based reconstructions of past climate variations have only used statistical proxy system models to make the link between climate model outputs and indirect observations from tree rings. However, the linearity and stationarity assumptions of the statistical approach may have limitations. In this study, we incorporate the process-based dendroclimatic model MAIDEN into a data assimilation procedure using the reconstruction of near-surface air temperature, precipitation and winds in the midlatitudes of the Southern Hemisphere over the past 400 years as a test case. We compare our results with a data assimilation approach including a linear regression as a proxy system model for tree-ring width proxies. Overall, when compared to instrumental data, the reconstructions using MAIDEN as a proxy system model offer a skill equivalent to the experiment using the regression model. However, knowing the advantages that a process-based model can bring and the improvements that can still be made with MAIDEN, those results are promising.
Variability in sea ice carbonate chemistry: a case study comparing the importance of ikaite precipitation, bottom-ice algae, and currents across an invisible polynya
Authors: Else Brent G. T. , Cranch Araleigh , Sims Richard P. , Jones Samantha , Dalman Laura A. , Mundy Christopher J. , Segal Rebecca A. , Scharien Randall K. , Guha Tania
Published: September 2022

Abstract. The carbonate chemistry of sea ice is known to play a role in
global carbon cycles, but its importance is uncertain in part due to
disparities in reported results. Variability in physical and biological
drivers is usually invoked to explain differences between studies. In the
Canadian Arctic Archipelago, “invisible polynyas” – areas of strong
currents, thin ice, and potentially high biological productivity – are
examples of extreme spatial variability. We used an invisible polynya as a
natural laboratory to study the effects of inferred initial ice formation
conditions, ice growth rate, and algal biomass on the distribution of
carbonate species by collecting enough cores to perform a statistical
comparison between sites located within, and just outside of, a polynya near
Iqaluktuttiaq (Cambridge Bay, Nunavut, Canada). At both sites, the uppermost
10 cm ice horizon showed evidence of CO2 off-gassing, while carbonate
distributions in the middle and bottommost 10 cm horizons largely followed
the salinity distribution. In the polynya, the upper ice horizon had
significantly higher bulk total inorganic carbon (TIC), total alkalinity
(TA), and salinity potentially due to freeze-up conditions that favoured
frazil ice production. The middle ice horizons were statistically
indistinguishable between sites, suggesting that ice growth rate is not an
important factor for the carbonate distribution under mid-winter conditions.
The thicker (non-polynya) site experienced higher algal biomass, TIC, and TA
in the bottom horizon. Carbonate chemistry in the bottom horizon could
largely be explained by the salinity distribution, with the strong currents
at the polynya site potentially playing a role in desalinization; biology
appeared to exert only a minor control, with some evidence that the ice
algae community was net heterotrophic. We did see evidence of calcium
carbonate precipitation but with little impact on the TIC:TA ratio and
little difference between sites. Because differences were constrained to
relatively thin layers at the top and bottom, vertically averaged values of
TIC, TA, and especially the TIC:TA ratio were not meaningfully different
between sites. This provides some justification for using a single bulk
value for each parameter when modelling sea ice effects on ocean chemistry at
coarse resolution. Exactly what value to use (particularly for the TIC:TA ratio) likely varies by region but could potentially be approximated from knowledge of the source seawater and sea ice salinity. Further insights await a rigorous intercomparison of existing data.
Affordances in collaborative robotic production for artisan crafts and hybrid design
Authors:   , Burden Alan G.
Published: September 2022

This thesis showed an industrial robot arm and augmented reality can complement handcrafting skills. The research studied artisans, finding a common technique was patternmaking – creating 2D templates for bending into 3D objects. A design process modified a workshop industrial robot to create 2D patterns. Additionally, a customised robot tool was designed for cutting and scoring materials, and an augmented reality headset allowed an artisan to control and see the robot’s planned actions. The findings show a hybrid approach of human and robot crafting techniques allowing artisans to make design objects in various sizes while maintaining the quality of the product.
A quantified facies scale depositional model for current controlled siliciclastic deep marine depositional systems
Authors:   , Devereaux Alexander R.
Published: September 2022

Detailed analysis was carried out on sediment samples collected from the Gulf of Cádiz during Integrated Ocean Drilling Program 339. Grain size analysis is a vital sedimentological tool used to unravel the hydrodynamic conditions, modes of transport, and depositional environment. Statistical parameters, bivariate analysis, and log-probability curves were used to quantify the physical sedimentological characteristics and compare them to previously established conceptual models.
Proteomic and bioinformatic investigation of chronic wounds using non-invasive sampling to assess wound status and pathology
Authors:   , Bagley Angus H.
Published: September 2022

This project explored the biochemistry of non-healing wounds, with aims of expanding the current knowledge on their associated protein profiles. Changes in the abundance levels of proteins within wound fluids were examined in relation to best-practice treatments, including compression therapy, and wound condition, including infection status and disease burden. A complex statistical methodology was developed to analyse wound proteomic mass spectrometry data. This approach identified a suite of significant and clinically relevant protein targets. These findings may benefit wounds research and clinical practice, as they offer insight into the biochemical impact of best-practice care and the effect on wound healing.
parenting couples' experiences of mental labour: How couples conceive, negotiate, share, and explain mental labour division
Authors:   , Elyse C. McNeil
Published: September 2022

This thesis examined how parenting couples manage mental labour; the thinking, organising, planning work that underpins running a family. This thesis used surveys of working mothers and fathers and interviews with parenting couples and found that mothers are responsible for a greater portion of the childcare and family mental labour while fathers are responsible for much of the household mental labour. Mothers experienced more negative impact from the mental labour they carry. Effective re-distribution to improve sharing of mental labour is possible, particularly when both parents have periods of primary caring.
Um diálogo: entrevista com Gisèle Sapiro
Authors: Sapiro Gisèle , Campos Névio de
Published: September 2022

Entrevista - Entretien avec Gisèle Sapiro
Sweet Water on the Sea Route to China
Authors: Lambourn Elizabeth
Published: September 2022

Potable, or “sweet,” water was the foundation stone of maritime provisioning and, by implication, route planning on all but the shortest voyages in the premodern world. Without it, maritime trade and all other forms of seaborne exchange and circulation were effectively impossible. Yet water sources and technologies of transportation have been comparatively neglected in Indian Ocean history and archaeology. This paper rereads data from the ninth-century section of the Akhbār al-Ṣīn wa-l-Hind (Accounts of China and India) alongside recent evidence from two contemporary shipwrecks to examine the spacing of watering stops and the technologies of water transportation employed on long-distance sailings between the Gulf and Chinese ports. Working from the 2021 publication of the volumetric capacity of a group of so-called torpedo jars excavated in Thailand, this article proposes some preliminary quantitative estimates of the volume of freshwater, and thus the number of water jars, required on board vessels at the time. In so doing it raises important questions about the portability and handling of torpedo jars as well as the varied uses and reuses of such transport jars. Weaving passages from the Akhbār with information on ceramic remains from the Phanom Surin and Belitung wrecks, this article aims to start a conversation about the very real physical and physiological parameters that underlay Indian Ocean connectivity and the water transportation technologies that underpinned them.
Analysis of psychological variables predicting stress and sports-academic engagement in judokas.
Authors: Carratalá-Bellod Helio , Guzmán-Luján José Francisco
Published: September 2022

The objective of this research was to know the relationship of the predictive variables of stress and commitment in the sports and academic context of adolescent judokas based on different personal characteristics, such as sex and sports level. Material and methods: A selective research methodology was used, with a retrospective ex-post-facto design. The sample consisted of 111 competing judokas (59 men and 52 women) aged between 11 and 19 years, all of them students of regulated secondary education. Results: In general, the sample effect size was large in variables like Sport Task Coping; medium in Sport Distancing Coping and short in Sport Emo- tion Coping. The correlational analysis between the variables of interest showed the existence of a negative relationship of stress with resilience and commitment, both in the academic and sports fields. Second, two clusters were extracted from the sample using the Ward’s method and taking into account the interval provided by the squared Euclidean distance standardized by Z scores and generating a dendrogram. The analyses carried out show the existence of two large groups of judokas with similar characteristics to each other and different from the rest. The results verified the relationship between stress variables and the commitment between the academic and sports context, therefore, the sports practice could be used as a means to improve stress coping strategies and to improve commitment in the academic field. Conclusions: Sports stress predicts academic stress, and sports stress and resilience predict academic engagement.
Correlation of Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with serum GDF-15 in a group of hypertensive Iraqi patients
Authors: Hatem Al Gburi Roaa , D. Hashim Raid , Ahmed Kadhim Hayder , Adam Şevki , Abdulkareem Almashhadani Haider
Published: September 2022

The Growth Differentiation Factor -15 (GDF-15) is a member of the transforming growth factor β superfamily. İt represents an example of the stress response cytokines. It's mostly found in cardiac myocytes, adipocytes, macrophages, endothelial cells, and vascular endothelial cells, whether they're generated normally or not. GDF-15 levels have increased and are associated with cardiovascular risk. Aim of the study: To investigate the correlation between angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) with the level of plasma GDF-15 in a group of hypertensive patients. Materials and methods: A case-control study involved 90 individuals, 60 hypertensive patients (36 on ACE inhibitors and 24 on ARBs) and 30 healthy individuals. Serum GDF-15 was measured and compared statistically between the two groups. Results: serum GDF-15 was significantly higher in both groups of hypertensive patients compared to the control group. İn addition, there was no significant difference in mean serum GDF-15 concentration between patients treated with ACE inhibitors with those treated with angiotensin II receptor blockers. Conclusion: GDF-15 increases in hypertensive patients and might be a reasonable marker of cardiovascular disease. Both ACE inhibitors and ARBs are not powerful enough to decrease GDF-15 concentration to that of the control group.
Status of HBeAg in association with other baseline tests in Iraqi patients with CHB
Authors: Raed Alheany Aya , Farouk Abdullah Shatha
Published: September 2022

Chronic Hepatitis B(CHB) is a serious sequel after Hepatitis B Virus infection, although the rate of chronicity is inverse with age but it may be associated with a significant proportion of deaths related to cirrhosis and liver cancer. HBV serology and measurement of hepatocytic enzymes with viral load can predict disease prognosis and response to treatment. HBeAg refers to a high viral replication and associated with more infectivity to others. This study aimed to determine the impact of HBeAg status in chronically infected patients on various baseline tests. A total of 90 patients with CHB infection who were included in this study. Several standardized measures used for liver function tests, viral load and hepatitis B serological markers. HBeAg was negative in 81/90 (90%) patients and positive in 9/90(10%). There was significant association between HBeAg serostatus and HBV-DNA viral load (p=0.042), as more than half of the cases (55.6%) had high levels of HBV serum DNA (≥2000 IU/ml) and positive HBeAg compared to 24.7% of cases with negative HBeAg. HBeAg seroconversion was not associated with liver function tests, modes of transmission, duration of chronicity, marital status, gender and age. We concluded that HBeAg sero-negativity among the studied cases can predict the inactive or reactive phase of chronic hepatitis B, if the latter is associated with high viral loads, so that further studies are needed to find out associated precore mutants.