bluuebunny/crossref_metadata_2025 huggingface dataset:
In silico study exploiting chromosomal replication initiator protein as a molecular target for new antibiotics in Shigella dysenteriae
Authors: Al-Khayyat Mohammed
Published: September 2024

Introduction: DNA chromosomal replication initiator protein, DnaA is a component of bacterial division machinery. Objetives: virtual screening of phytochemicals for new antibiotics at novel molecular targets. Materials and Methods: SWISS-Model tool was used in homology modeling of this protein and validation tools were also used to check for its accuracy. The evaluation tools were ERRAT, PROCHECK and Molprobity servers. The refined model by GalaxyWEB server, then employed in molecular docking experiments. A total of 300 natural products were used in virtual screening for lead compounds targeting the model by AutoDock Vina software. Results and Discussion: Corylin among then best ligands that have binding affinities lower than ADP as control. Interactions in the form of hydrogen bonds and hydrophobic interactions were analyzed by LigPlot. The best compounds were submitted into iGEMDOCK docking tool for consensus scoring approach. admetSAR 2.0 was used to predict for pharmacokinetics, interactions and toxicities of these ligands inside the human body. Conclusions: Therefore, preliminary screening of lead compounds must be accompanied by studying pharmacologic properties.
The Present and Future of Local Self-Government in the Republic of Kazakhstan
Authors:   Jagiellonian University (Poland), Pachucki-Włosek Krystian
Published: September 2024

After the collapse of the Union of Soviet Socialist Republics (USSR), Kazakhstan’s policymakers recognized that the existing model of state governance had proved ineffective and needed to be changed. One of the necessary solutions was to carry out decentralization. The primary purpose of the following article is to outline the barriers that Kazakhstan needs to remove if it is serious about building local self-government independence. Confronting these with the President’s vision of the transformation of local self-government led to the following research questions: What organizational and legal issues remain unresolved or constitute a barrier to the construction of independent local government structures in the Republic of Kazakhstan after the collapse of the Soviet Union?; to what extent do the changes proposed by President Kasym Tokayev meet the real challenges in the context of expanding the autonomy of local power structures? Answering the questions posed was possible by analyzing legal acts and finding literature and press materials.
Postoperative complications and predictors of mortality in surgery for left-sided infective endocarditis: a single-center retrospective study
Authors: Enginoev S. T. , Demetskaya V. V. , Kozmin D. Yu. , Pasyuga V. V. , Demin D. A. , Demina E. V. , Stompel D. R. , Chernov I. I.
Published: September 2024

Aim. To assess postoperative complications and predictors of mortality in surgery for left-sided infective endocarditis (IE).

Material and methods. The retrospective analysis included 222 cases of IE in 216 patients who were operated on from January 2015 to November 2022. Inclusion criteria: age of patients ≥18 years, definite or probable (Duke criteria) left-sided IE of aortic and/or mitral valves. There were following exclusion criteria: isolated right-sided IE (tricuspid valve, pacemaker endocarditis), nonbacterial thrombotic endocarditis and chronic IE. Endpoints: inhospital mortality, postoperative complications (delirium; perioperative stroke; resternotomy for bleeding; perioperative myocardial infarction; acute heart failure requiring extracorporeal membrane oxygenation or intra-aortic balloon pumping; respiratory failure requiring tracheostomy; acute kidney injury requiring renal replacement therapy; conduction disorder requiring pacemaker implantation).

Results. Median age was 53 [38,0; 61,0] years, while the majority of patients were men (73,9%). Inhospital mortality was 8,6%. The most common postoperative complications were delirium (19,8%) and bleeding requiring resternotomy (10,4%). The incidence of perioperative stroke was 2,3%, perioperative myocardial infarction - 0,9%, respiratory failure with tracheostomy – 4,5%, pacemaker implantation – 2,7%, renal replacement therapy – 6,8%. According to multivari ate analysis, Predictors of inhospital mortality were creatinine clearance level (odds ratio (OR), 0,976; 95% confidence interval (CI): 0,956-0,996; p=0,020), time of cardiopulmonary bypass (OR, 1,014; 95% CI: 1,006-1,021 , p<0,001), deli rium (OR, 7,058; 95% CI: 1,824-27,330, p=0,005) and acute kidney injury requiring renal replacement therapy (OR, 28,620; 95% CI: 6,508-125,964; p<0,001).

Conclusion. Surgical treatment of left-sided IE has satisfactory inho spital outcomes. The study identified simple clinical factors (creatinine clearance, cardiopulmonary bypass time, delirium, acute kidney injury) associated with inhospital mortality.
Pulse oximetry methods: opportunities and limitations
Authors: Garanin A. A. , Dyachkov V. A. , Rubanenko A. O. , Reprintseva O. A. , Duplyakov D. V.
Published: September 2024

The aim of this review was to evaluate the current literature on various methods of pulse oximetry, their advantages and disadvantages. Modern pulse oximetry methods generally correlate well with invasive saturation monitoring, which makes it possible to be widely used in clinical practice. At the same time, in order to improve the accuracy of saturation measurements, existing limitations of various pulse oximetry methods should be taken into account. The emergence and introduction into clinical practice of reflectance pulse oximetry can largely compensate for the limitations of traditional transmission pulse oximetry regarding peripheral hypoperfusion, low response time, and features of patient's nails. In the event of special situations when pulse oximetry may not be accurate enough (carbon monoxide poisoning, methemoglobinemia, severe anemia, severe tricuspid insufficiency, etc.), a thorough clinical assessment of the patient is recommen ded, as well as invasive saturation monitoring.
Samrefleksjon – en veiledningsmetodikk for sykepleierstudenter i praksis?
Authors: Bjerga Grethe Heidi , Lode Kirsten , Bakken Janet , Jaastad Turid Anita , Brandeggen Tone
Published: September 2024

I denne studien utforskes sykepleierstudenters erfaringer med samrefleksjon over praksisfortellinger ut fra et definert rammeverk, for å få dypere forståelse av studentens lærings- og danningsprosess i klinisk praksis.
Studien har et kvalitativ design. Deltakerne var studenter som hadde praksis i spesialisthelsetjenesten. Andre- og tredje års studenter deltok i studien. Datamaterialet var skriftlige refleksjonsnotater som ble analysert ved hjelp av tematisk analyse. Tre temaer kom frem av analysen: Betydningen av samrefleksjon for forståelse av sykepleie, betydningen av samrefleksjon for utøvelse av sykepleie og betydningen av samrefleksjon for studentens danningsprosess mot å bli sykepleier.
Resultatet viser at samrefleksjon i veiledning, der teori relateres til praksisfortellinger, fremmer forståelse og kunnskap. Denne forståelsen og kunnskapen kan bidra til kompetanseutvikling og kvalitet i utøvelse av omsorg og sykepleie. Utdanningen bør legge til rette for veiledning med samrefleksjon som ivaretar studentene og stimulerer deres lærings- og danningsprosess mot å bli sykepleier.
Exploring the Effects of Medical Plasma Treatment on MRSA-Infected Mice: A Promising Approach for Pain Relief Therapy
Authors: Kamaruddin Mudyawati , Darmawati Sri , Febiaocti Rizka Yolanda , Hayati Defi Nurul , Putri Gela Setya Ayu , Muslimah  , Noviasari Nina Anggraeni , Fatmawati Andi , Triananinsi Nurhidayat , Utami Rinda Aulia
Published: September 2024

The sensation of pain in wounds is attributed to the secretion of Substance P (SP), an 11-amino acid neuropeptide that functions as both a neurotransmitter and a neuromodulator. SP is produced by the central nervous system, peripheral nervous system, and immune cells. Research is also underway to study suppression of SP activity as a potential treatment for pain. Medical plasma can mitigate discomfort during wound healing. The ability of plasma therapy to expedite healing and diminish infections may alleviate discomfort during wound healing. The decrease in pain can be quantified by measuring the SP levels during medical plasma treatment. The objective of this study was to investigate the efficacy of medical plasma therapy in reducing pain in methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds by analyzing SP levels and fibroblast, neutrophil, and platelet levels as supporting data for SP. In this investigation, a prototype of a medical plasma technology of the atmospheric pressure jet type was categorized into four treatment groups: control (K), group with plasma treatment at a distance of 5 mm [control plasma (CP)], group with plasma treatment at a distance of 20 mm [noncontact plasma (NCP)], and group with plasma treatment at a distance of 5 and 20 mm (CP-NCP). The study revealed that SP levels decreased in the treatment groups administered medical plasma (CP, NCP, and CP-NCP) compared to the control group during the treatment period (14 days), and SP levels significantly decreased on days 11 and 14. The lowest levels recorded on D14 were 517.755, 684.45, and 790.19 pg/mL, followed by 985.685, 1120.24, and 1205.905 pg/mL on day 11. A decrease in SP levels indicates loss of pain in the wound. Administration of medical plasma to MRSA-infected wounds had a positive effect on pain relief in mice, which also helped in faster wound healing.
Türkçe Öğretmenlerinin Masal ve Destanlarımız Dersine Yönelik Görüş ve Uygulamaları
Authors: Kayman Faruk , Elkatmış Veysel , Avcı Mehmet Salih
Published: September 2024

Bu araştırmanın amacı, ortaokullarda okutulan seçmeli Masal ve Destanlarımız dersine ilişkin Türkçe öğretmenlerinin görüş ve uygulamalarını tespit etmektir. Nitel araştırma yöntemlerinden durum çalışması deseni kullanılarak gerçekleştirilen araştırmanın çalışma grubunu 2023-2024 eğitim öğretim yılında devlet okullarında görev yapan 29 Türkçe öğretmeni oluşturmuştur. Veri toplama aracı olarak yarı yapılandırılmış görüşme formu kullanılmış, elde edilen veriler içerik analizi kullanılarak çözümlenmiştir. Araştırma sonuçlarına göre, öğretmenlerin çoğunluğu dersin okutulması gerektiğini düşünmektedir. Dersin okutulmasını savunanlar, kültür aktarımını önemli bir gerekçe olarak belirtirken karşı çıkanlar ise benzer içeriğin Türkçe dersinde yer aldığını vurgulamıştır. Öğretmenlerin dersle ilgili yaşadıkları en büyük sorunlar arasında kitap ve materyal eksikliği ile öğrencilerin ilgisizliği öne çıkmıştır. Katılımcıların derste video izletme, yaratıcı yazma ve okuma etkinliklerini sıkça kullandıkları görülmüştür. Ölçme ve değerlendirme yöntemi olarak ise en çok açık uçlu sorular tercih edilmiştir. Öğretmenler dersle ilgili materyal ve kaynak yetersizliğinden yakınmış, ders kitabının hazırlanması, kaynakların belirlenmesi ve etkinlik kitaplarının hazırlanması gibi önerilerde bulunmuşlardır.
Bread dough as material metaphor for the maternal experience
Authors: Pond Julia
Published: September 2024

This article traces my artistic practice with bread dough. The writing intertwines descriptions of practice and theory, exposing the ambiguities of maternal experience through the dough. Beginning with research on suspended temporalities, the dough reveals multi-layered insights into physical and economic maternal experience. Materialities of bread dough work together with embodied practices which explore them: slow, spreading growth, stickiness, weight and awkwardness,  kneading as rhythmic, repetitive labour, invisibility. The writing connects the research to the performance project BRED, a participatory installation depicting a fictional start-up company, in which the dough stars as the object of ‘work,’ here no longer invisible, a vehicle for the voice of the maternal within a performative corporate setting.
Vernacular Policies of Feeling: Sensuous Presence and the Emergence of an AIDS-Era Sexual Health Ethic
Authors: Mitchell Ryan
Published: September 2024

Before the isolation of HIV in 1984, members of queer sex communities developed robust explanatory frameworks for not only understanding AIDS but also mitigating its possible sociopolitical consequences. These frameworks retooled political values inherited from past modes of sexual health activism to introduce flexible, future-oriented sexual health policies. This essay considers how AIDS commentators working during the first year-and-a-half of the crisis tailored their speculative arguments about appropriate AIDS-era sexual health ethics in ways that attempted to address the enigmatic epidemic’s intersecting medical, political, and sexual crises. Drawing on work that considers the embodied dimensions of Perelman and Olbrechts-Tyteca’s concepts of presence and communion, I argue that, in the absence of clear biomedical information about AIDS, early AIDS commentators devised what I call vernacular policies of feeling. Unlike traditional health policies that rely on empirical evidence, vernacular policies of feeling make present communal ways of sensing risks to stabilize biomedical controversy, induce collective action, and affirm community values. Along with demonstrating how the body serves as a rhetorical resource for those made vulnerable to illness and death, vernacular policies of feeling productively illustrate how non-expert communities construct future-oriented arguments in moments of overwhelming contingency.
METHODOLOGICAL APPROACH TO ASSESSING THE IMPACT OF ENERGY EFFICIENCY ON THE FINANCIAL PERFORMANCE OF A GAS COMPANY
Authors: Gayfullina M.M.
Published: September 2024

Currently, the use of energy-saving technologies that reduce costs and improve the production process is the most important factor in the development of the gas industry. The relevance of the research topic is due to the fact that in order to resolve issues related to reducing energy costs in the gas sector of the Russian economy, optimal use of non-renewable energy resources, and reducing technological losses, an integrated approach to assessing energy efficiency is required, as well as a methodology for assessing the impact of energy efficiency indicators on the financial performance of a company. The purpose of this article is to develop a methodological approach to assessing the impact of the level of energy efficiency on the financial performance of a gas company. The research methodology is based on correlation and regression analysis tools. As part of the study, a system of energy efficiency indicators for a gas company's activities has been formed and, using correlation and regression analysis tools, a methodology for assessing the impact of the level of energy efficiency on the financial performance of a gas company is proposed. An algorithm for correlation and regression analysis is presented, which makes it possible to formalize a step-by-step assessment of the impact of the level of energy efficiency on the financial performance of a gas company. The proposed methodological approach allows us to identify correlation-regression dependencies between the company’s key performance indicators (sales revenue and net profit) and the proposed energy efficiency indicators, determine the most significant indicators that affect the company’s performance indicators and determine the equation for the relationship between the company’s performance and energy efficiency indicators. Testing of the proposed approach using the example of the gas company PJSC Gazprom made it possible to quantify how changes in the energy intensity of gas production and the energy intensity of gas transportation will affect changes in sales revenue and net profit of the company. It has been established that the energy efficiency indicator such as the specific energy intensity of gas transportation has the greatest impact on the financial performance of the company. Regression equations have been established to describe the nature of the relationship between energy efficiency indicators and sales revenue and net profit of a gas company.
Enacting Technoscience: Art & Science From the Contemporary Metaphysics Perspective
Authors:   National Research University — Higher School of Economics (HSE University), Moscow, Russia, Alekhina Anastasia , Pisarev Alexander ,   Institute of Philosophy, Russian Academy of Science (RAS), Moscow, Russia
Published: September 2024

In the article the assumptions, strategies and possibilities of Art & Science (A&S) are considered through the prism of three types of metaphysical thinking. These types are defined by the answers to the question: why is there something rather than nothing. Thus, the analysis of classical metaphysics makes it possible to identify the basic assumptions of many A&S projects. These assumptions are borrowed by art from the public self-presentation of science and from Western common sense: there is an autonomous and definite nature, it is successfully known and mastered by science. So nature is nature, and nothing more. These assumptions are disputed by post-Kantian transcendental ontology. It opens up for A&S the opportunity to reflect upon the givenness of nature in the experience mediated by science, namely the constitution of science’s own objectivity, the social and political factors involved, as well as naturalization processes that turn scientific objects into nature things by way of erasing their origin. Nature is in the eye of the beholder. Empirical metaphysics (a number of projects from STS) sheds light on laboratory practices of nature enactment and the role of non-human actors in these processes. Nature is not only in the eye of the beholder, but also in the hands of the doer. It is assembled gathers, among other things, from the tissues of society, politics, culture, so does not oppose them from the outside. Among other things, this move allows us to define Art & Science as the enactment or performance of technoscience, since the laboratory-technical aesthetics inherent in this art is a reenactment of the part of the technoscientific network of practices and actors. In conclusion, by means of Pierre Bourdieu’s critical sociology, a hypothesis is formulated explaining why an alliance with STS may be problematic for A&S artists, and why posthumanism and new materialism are assimilated in this art in a cliched form. The technoscientifically formed world requires technoscientific enlightenment based on STS and philosophy, and A&S in alliance with them can be its art.
Effect of Poor Post-Slaughter Handling on Physicochemical and Microbial Quality of Fresh Broiler in Bangladesh
Authors: Md. Kamruzzaman , Md. Rasel Islam , Ananya Raiyan , Md. Mohasin Hossain , Md. Ashrafuzzaman Zahid , Rashida Parvin
Published: September 2024

The slaughtering method and post-handling play an important role in meat processing. Countries followed different slaughtering methods, post-handling, and preservation techniques for post-slaughtered meat. Stress-oriented slaughtering, unhygienic handling, processing, and improper preservation are triggering factors of rapid oxidation and microbial proliferation in meat during storage. Bangladesh is a Muslim-oriented country but many vendors do not follow the halal slaughtering, and handling of meat in an unhygienic way due to a lack of food safety knowledge. Thus, the study aims to assess the effect of poor post-slaughtering handling practices on the physiochemical properties which include moisture, ash, protein content, fat content, drip loss, cooking loss, water holding capacity, pH, fat oxidation, color, heme iron, mineral content, and microbial qualities of fresh samples by total plate count during 0 days, 15 days and 30 days frozen storage at -18ºC. The live broiler was purchased randomly and slaughtered instantly from different slaughter shops in Jashore City, Bangladesh. The laboratory analysis was performed following the standard method of meat sample analysis. The outcome of this study revealed that heme iron content, minerals like Ca, Fe, Zn, and lightness values decreased significantly (p < 0.05) during 30 days of storage at -18 ºC. Post-handling had no significant effect (p > 0.05) on protein and ash content at 0 and 15 days of storage but slowly decreased with increasing storage time. The continuous increase in pH, cooking loss, and TBARS value indicate rises in lipid oxidation noticed in all samples, especially during 16-30 days of frozen storage (p < 0.05). The total viable count significantly raised (p < 0.05) and reached the highest value of 7.27 log10 CFU/g and 7.44 log10 CFU/g respectively after 15 days and 30 days of frozen storage compared to fresh condition. Bacteriologically meat samples were of very poor quality during storage compared to fresh ones.
An Advantageous Numerical Method for Solution of Linear Differential Equations by Stancu Polynomials
Authors: Nese Isler Acar
Published: September 2024

In this study, a numerical method that is alternative to the Bernstein collocation method has been investigated for solution of the linear differential equations. The theory of the method has been constituted by considering the Stancu polynomials and their algebric properties. The applicability of the method has been indicated on initial and boundary value problems. In addition, the numerical results of the proposed method have been compared with the numerical results of the known method had the best approximation in the past studies. Therefore, whether usability and efficiency of the proposed method is or not has been presented. 2020 Mathematics subject classification: 41A10, 65L05, 65L10 , 65L60
Fortalezas psicológicas, liderazgo y satisfacción laboral en entrenadores de fútbol en España
Authors: Gutiérrez Caballero Juana María , Blázquez Manzano Alberto , Feu Molina Sebastián
Published: September 2024

The aim of the paper is to study self-perceived leadership, job satisfaction and personal strengths in 260 Spanish football coaches. Specifically, two dimensions of leadership are studied: coaching and instruction and positive feedback; and two of personal strengths: credibility and people development. In addition, a structural equation model is tested to study whether (a) these personal strengths predict (b) job satisfaction and (c) the reported leadership behaviours. The Football Coaches Personal Strengths Questionnaire, the Job Satisfaction Scale and the Sport Leadership Scale for Coaches (SS1) are used.
The strengths of the relationship on the psychological dimensions studied are: credibility-people development (β = .87); on the job satisfaction of the football coaches consulted: credibility (β = .21) and people development (β = .15). And, finally, on the self-perceived leadership variables by the coaches are: credibility-positive feedback (β = .43) and people-building-instruction (β = .58). We conclude with the importance of the psychological aspect in football coaches, taking into account that these variables studied are also relevant to the well-being and performance of football players.
Real-time and programmable transcriptome sequencing with PROFIT-seq v1
Authors: hou lingling , Zhang Jinyang
Published: September 2024

PROgrammable Full-length Isoform Transcriptome sequencing (PROFIT-seq) is a method that enriches target transcripts while maintaining unbiased quantification of the whole transcriptome. PROFIT-seq employs combinatorial reverse transcription to capture polyadenylated, non-polyadenylated, and circular RNAs, coupled with nanopore adaptive sampling that selectively enriches target transcripts during sequencing.
EVALUASI PENERAPAN RENCANA PELAKSANAAN PEMBELAJARAN DALAM KEGIATAN PEMBELAJARAN MATA PELAJARAN PEMROGRAMAN DASAR KELAS X DI SMK CENDIKA BANGSA MALANG DENGAN METODE CIPP
Authors: Amalia Novita Rizki
Published: September 2024

Based on observations that have been made at SMK Cendika Bangsa Malang, it is known that during the learning process, teachers do not use lesson plans. According to the results of interviews, teachers consider that lesson plans are only a formality, this is feared to affect student learning outcomes because the learning process is less effective. Based on these problems, a research was conducted that aims to determine the application of lesson plans in learning activities for basic programming subjects for class X at SMK Cendika Bangsa Malang with the CIPP method. The data was collected by interview, observation, document study, and documentation methods. Informants in this evaluation activity are Deputy Head of Curriculum, Teachers, School Supervisors, and Students, other data sources are documents such as Basic Programming Plans, Syllabus, Annual Programs, Semester Programs, and Minister of Education and Culture Regulation no. 22 of 2016 concerning Standards for Primary and Secondary Education Processes. From the results of the research that has been done, it can be concluded that at the context stage, the preparation of learning documents by the teacher still needs to be improved. At the input stage, the teacher still needs to review the syllabus. At the process stage, the teacher has implemented some of the steps from the lesson plan, so that the learning activities are appropriate but still need to be improved, at the product stage students have scored above the KKM.Berdasarkan observasi yang pernah dilakukan di SMK Cendika Bangsa Malang, diketahui bahwa saat proses pembelajaran, guru tidak menggunakan RPP. Menurut hasil wawancara, guru menganggap bahwa RPP hanya sebagai formalitas saja, hal ini dikhawatirkan dapat memengaruhi hasil belajar siswa karena proses pembelajaran yang kurang efektif. Berdasarkan permasalahan tersebut, dilakukan penelitian yang bertujuan untuk mengetahui penerapan RPP dalam kegiatan pembelajaran mata pelajaran pemrograman dasar kelas X di SMK Cendika Bangsa Malang dengan Metode CIPP. Pengumpulan data dilakukan dengan metode wawancara, observasi, studi dokumen, dan dokumentasi. Informan pada kegiatan evaluasi ini adalah Wakil Kepala Kurikulum, Guru, Pengawas Sekolah, dan Siswa, sumber data lain adalah dokumen seperti RPP Pemrograman Dasar, Silabus, Program Tahunan, Program Semester, dan Peraturan Menteri Pendidikan dan Kebudayaan No. 22 Tahun 2016 mengenai Standar Proses Pendidikan Dasar dan Menengah. Dari hasil penelitian yang telah dilakukan diperoleh kesimpulan bahwa pada tahap context, penyusunan dokumen pembelajaran oleh guru masih perlu diperbaiki lagi. Pada tahap input, guru masih perlu mengkaji ulang silabus. Pada tahap process, guru sudah menerapkan sebagian langkah dari RPP, sehingga dalam kegiatan pembelajaran sudah sesuai namun masih perlu ditingkatkan, pada tahap product siswa telah mendapat nilai diatas KKM.
EDUCATIONAL TECHNOLOGY UNDERGRADUATE DEGREE TRACER STUDY TOWARDS SKILLS AND JOBS PERSPECTIVE
Authors: Setiawan Budi - , Fathoni Toto - , Sukirman Dadang -
Published: September 2024

One indicator of a good education system is the existence of a system that is used to measure the output of education itself. Determination of measurements to determine the quality of graduates or alumni include the achievement of graduate competencies, the problems faced can be solved, the career achievements of graduates, as well as things that are either in alignment or not in harmony with the quality of alumni with the quality expected by the university. A good and intact education system has a loop-shaped educational system flow. The education system is the responsibility of universities to students, not ending when students have graduated from college, but also related to the career sustainability of graduates or alumni who are more ready to enter the community. College tracer study is one way to find out the role of alumni in society. Based on the characteristics of alumni or graduates of the Education Technology Study Program, the number of graduate data is 90 people and those who enter fill out questionnaires. Alumni or graduates who filled out the questionnaire were 90 people consisting of (70%) women and (30%) men. Alumni or graduates of the Education Technology Study Program have a study graduation time of 90%, meaning no more than 8 semesters, while 10% do not graduate on time, meaning more than 8 semesters. Alumni or graduates of the Education Technology Study Program overall average GPA of the highest respondents are respondents who have a GPA above 3.5. Alumni or graduates of the Education Technology Study Program show that the highest average employment status is respondents who work. Alumni or graduates of the Education Technology Study Program with the criteria for institutions/institutions/companies that graduates work show the highest average graduates work in private institutions/institutions/companies.
INOVASI KURIKULUM DALAM ASPEK TUJUAN DAN MATERI KURIKULUM PAUD
Authors: Azzahra Indah Maysela , Triyana Triyana , Sukiman Sukiman
Published: September 2024

Perubahan kurikulum yang terjadi di Indonesia merupakan salah satu bentuk Inovasi untuk merencanakan pembelajaran dan meningkatkan kualitas mutu pendidikan lulusan siswa yang lebih maju dan optimal. Tujuan penelitian yaitu untuk mengetahui dan membandingkan tujuan dan materi kurikulum PAUD Tahun 1994-2013. Metode penelitian yang digunakan adalah metode kualitatif dengan pendekatan studi pustaka. Pengumpulan data dilakukan dengan cara mencari sebanyak-banyaknya informasi terkait inovasi kurikulum dalam aspek tujuan dan manfaat kurikulum dan kurikulum PAUD mulai dari kurikulum tahun 1994 sampai dengan tahun 2013. Analisis data yang digunakan adalah analisis model interaktif Miles dan Huberman. Tahapan analisis data terdiri dari data collection, data reduction, data disply, dan data verification. Hasil penelitian yaitu adanya perbaikan dan pembenahan dalam kurikulum dari setiap kurikulum-kurikulum yang ada sebelumnya apabila ditinjau dari aspek tujuan dan materi kurikulum. Kurikulum yang sangat jelas telihat mengalami inovasi yaitu pada kurikulum tahun 2004. Melakukan pembandingan tujuan dan materi kurikulum PAUD, diharapkan dapat berguna bagi lembaga PAUD untuk melakukan inovasi kurikulum lembaga PAUD sendiri
PERAN ORANG TUA DALAM PENGGUNAAN ALAT KOMUNIKASI ELEKTRONIK PADA JENJANG SEKOLAH DASAR
Authors: Fachrunnisa Anindita
Published: September 2024

The purpose of the study is to find out how the role of parents in the use of information and communication technology in online learning situations is carried out by their children who are at the elementary level. Due to the current pandemic conditions, elementary school students are learning at home online. With the assistance of parents, elementary school students must still be given directions in online learning using electronic communication tools. This study adopts a qualitative methodology with five participants who will be given a questionnaire by the researcher. The answers to each of these will then be analyzed as a result of this study. The results of this study reveal that the role of parents is very important in guiding, assisting, and supervising children in the use of electronic communication tools.
PENGEMBANGAN SISTEM COMPUTER ADAPTIVE TEST (CAT) DENGAN PENDEKATAN ITEM RESPONSE THEORY (IRT)
Authors: Firdaus Firdaus , Huda Asrul , Irfan Dedy , Hebdriyani Yeka
Published: September 2024

This study aims to produce a Computer Adaptive (CAT) system with an Items Response Theory (IRT) approach in Multimedia for Students of SMK Negeri 1 Gunung Talang. This research is a research on the development of a web-based system using the RD (Research and Development) method by applying the 4-D (Four-D) models. Basically this system is almost the same as the CBT (Computer Based Test) system, the difference from this system is that the system is able to randomize and give questions according to the ability of the test takers by using the Items Response Theory (IRT) algorithm. This system uses the Items Response Theory 3-PL model in which the parameters of this model are the level of difficulty of the items, the discriminating power of the questions and the questioning or distraction. This test system will give questions randomly to students based on the test takers' responses to the previous questions, In this system, each test taker will never get the same order of questions. Termination of the test when the test taker has reached the level of accuracy of the ability estimate, namely SE = 0.01 or if the items have been exhausted. The result of this research is a Computer Adaptive Test (CAT) system with an Items Response Theory (IRT) approach, which can be used in the process of assessing student learning outcomes. The implementation of this research is applied in the Multimedia Department of SMK Negeri 1 Gunung Talang with Printing Graphic Design Subjects.
Technology-enriched learning and retention of abstract concepts among first year electrical/electronic technology students in Nigerian Universities
Authors: Efuwape Bamidele Michael , Efuwape Oluwabunmi Asake
Published: September 2024

Technology-enriched learning was integrated into the teaching of abstract concepts in electrical/electronic technology with investigation of its effects on students’ academic performance and learning retention. A quasi-experimental design was adopted for the study. All 178 technical education students specializing in electrical/electronic technology from the 4 universities offering the programme in the south-west, Nigeria were involved in the study. The achievement test instrument used for data collection has a reliability coefficient of .92 obtained through test retest technique. Six research hypotheses were tested in the study. Data collected were analysed using analysis of covariance (ANCOVA) at 0.05 level of significance. The findings of the study established that technology enriched learning significantly improves students’ academic performance (F(1, 169) = 12.707; p = .000) and retention (F(1, 169) = 94.097; p = .000) compared to traditional lecture method. It was recommended that the idea of technology-enriched learning should be adopted by university teachers to foster effective teaching of abstract concepts in science and engineering while traditional lecture method should be discouraged in the teaching of abstract concepts.
Developing module of digital communication for professional contexts
Authors: Permatasari Alfelia Nugky , Soelistiyowati Endang , Vardhani Nabilla Kusuma , Nugroho Vincentius Tangguh Atyanto
Published: September 2024

This study aims to develop digital communication module that can be used by the general public for professional communication contexts. The module has been developed using the Define, Design, Development, Dissemination (4D) model: Define includes determining a digital communication platform along with the goals and etiquette needed; Design includes making a blueprint for the module; Development includes the development of the module as a whole by involving expert judgment; then Dissemination includes dissemination/publication of the module. From the Define and Design stages, the initial design of the module is obtained. Expert assessment at the Development stage shows that the module design is useful for audiences and is appropriate for dissemination with minor improvements for further dissemination in a form of a book at the Dissemination stage.
EKSTRAKURIKULER SENI MUSIK : MEMBENTUK KARAKTER BERKEBUTUHAN KHUSUS?
Authors: Habib Ahmad , Purnamawati Wasi , Octaviani Ayuni , Sumantri Moh. Syarif
Published: September 2024

Tujuan penelitian ini adalah mendiskripsikan pelaksanaan ekstrakurikuler seni musik dan nilai-nilai karakter pada anak berkebutuhan khusus ADHD yang terbentuk melalui ekstrakurikuler seni musik. Metode yang digunakan adalah kualitatif deskriptif, pengumpulan data dilakukan dengan teknik observasi dan wawancara. Pemeriksaan keabsahan data dilakukan dengan teknik triangulasi sumber, yaitu pengecekan terhadap informasi hasil wawancara dan observasi. Pelakasanaan dan pelayanan pada anak berkebutuhan khusus ADHD sudah baik, melalui pemberian perhatian lebih, membiarkan anak berkebutuhan khusus ADHD memilih alat musik yang disukai, membiarkan menggunakan alat musik, diarahkan untuk menyesuaikan dengan grup, dan memberikan apresiasi setelah melakukan tugas. Nilai-nilai karakter yang ditemukan pada anak berkebutuhan khusus ADHD melalui ekstrakurikuler seni musik mampu membentuk karakter religius, displin, kreatif, rasa ingin tahu, bersahabat atau komunikatif, peduli sosial, dan tanggung jawab.
BUKU KENDALI SEBAGAI MEDIA IMPLEMENTASI PENGAMALAN NILAI-NILAI PANCASILA DAN KONSTITUSI SEKOLAH DALAM UPAYA MENGUATKAN PENDIDIKAN KARAKTER
Authors: Saekhu HM Ahmad , Prihatono Yuda
Published: September 2024

Pendidikan karakter bangsa perlu mendapat perhatian serius dari berbagai pihak. Peran keluarga dan masyarakat belum sepenuhnya terlibat, seolah-olah hanya sekolah yang bertanggung jawab untuk menumbuhkan dan membentuk karakter anak-anak. Untuk memastikan pembiasaan karakter siswa, diperlukan pengawasan dari guru, orang tua dan masyarakat yang terlibat dalam penguatan program pendidikan karakter. Pengawasan dimaksudkan untuk menentukan pembiasaan karakter siswa di lingkungan sekolah, keluarga, dan masyarakat dalam bentuk buku kendali. Tujuan dari penelitian ini adalah untuk menghasilkan model buku kendali dalam mengimplementasikan penerapan nilai-nilai Pancasila dan konstitusi sekolah dalam memperkuat pendidikan karakter siswa kelas 5c SDN Ciwangi. Secara khusus penelitian ini bertujuan untuk menggambarkan: (1) Proses pengembangan buku prototipe kendali karakter; dan (2) Kepraktisan buku kendali dalam menerapkan pembiasaan pendidikan karakter. Penelitian ini menggunakan pendekatan kualitatif, yang terdiri dari tiga langkah, yaitu: tahap studi pendahuluan, tahap pengembangan, dan tahap pengujian, dengan metode penelitian studi kasus. Dengan Buku kendali ini untuk siswa diharapkan dapat terbentuk karakter mulia seperti yang diharapkan oleh sekolah, keluarga, dan masyarakat, dan untuk menanamkan nilai-nilai Pancasila dalam generasi Indonesia yang kuat dalam menghadapi globalisasi.
SPATIAL SENSE ABILITY INSTRUMENT FOR PRIMARY SCHOOL STUDENTS
Authors: Putri Hafiziani Eka , Nuraeni Fitri , Haftani Dwi Anisa , Rosalia Elvira , Pratama Nouval
Published: September 2024

This research is motivated by the importance of spatial sense skills possessed by elementary school students. The research aims to develop an instrument of spatial sense ability suitable for elementary school students. The indicators developed in the preparation of questions include: 1) classifying real objects into 3D form (building space); 2) investigating, exploring, and describing geometry in nature and the real world; 3) exploring the directional relationship of objects in space; 4) analyzing the nature of 3D shapes and interpreting 3D shapes into 2D forms. Research and Development was chosen as the method of this research. A total of 33 grade VI students of SDN 1 Nagri Kidul, Purwakarta Regency, West Java Province, were the samples in this study. The sample was selected by purposive sampling. The instrument used is an essay test consisting of seven questions regarding the geometry of cubes and blocks. The expert (Professor in the field of mathematics education) validated the seven questions that had been prepared. Expert considerations are used as the basis for the improvement of the compiled questions. Then the questions that have been corrected are tested on the research sample. The results of the trial were calculated for validity, reliability, difficulty index, and discriminatory power. Of the seven questions compiled, six were declared valid, reliable, and had high discriminatory power, and the level of difficulty of the questions consisted of medium and difficult. Thus, 6 of the seven items developed can be used by teachers or researchers as an instrument to measure the spatial sense abilities of elementary school students, primarily fifth-grade students.
Development of geometric model of the main building of Ivanovo CHPP-2 in Ansys PVK
Authors:   Ivanovo State Power Engineering University, Bukhmirov V.V. , Bushuev E.N. ,   Ivanovo State Power Engineering University, Svetushkov I.I. ,   Ivanovo State Power Engineering University, Temlyantseva E.N. ,   Siberian State Industrial University, Dolinin D.A. ,   Ivanovo State Power Engineering University
Published: September 2024

Modeling of the heat-air regime in the main body of the TPP in the scientific and technical literature is given insufficient attention. To simulate the heat-air regime in the main building of a thermal power plant, it is necessary to develop a geometric model of the boiler-turbine shop. A mathematical model of the heat-air regime in the main building of the TPP will allow us to develop energy-saving measures and improve the microclimate in the premises of the plant. The study has been carried out using mathematical modeling methods based on the DesignModeler graphic editor in ANSYS software. A geometric model of the boiler-turbine shop of Ivanovo combined heat and power plant-2 (CHPP-2) has been developed. It allows us to develop a mathematical model of heat and mass transfer in the air space of the main building of the plant. The three-dimensional geometric model of Ivanovo CHPP-2 is the first stage of the development of an integrated mathematical model of the heat-air regime of the main building. Its aim is to evaluate measures that reduce consumption of thermal and electrical energy for the in-house needs.
Markers of early post-stroke cognitive impairment
Authors: Tynterova A. M. , Barantsevich E. R.
Published: September 2024

Aim. To identify significant indicators of cognitive dysfunction based on discriminant analysis and to assess the influence of the course, nature and localization of ischemic stroke on the cognitive status of the patient.

Materials and methods. We examined 290 patients diagnosed with ischemic stroke in the carotid artery area. Depending on presence of cognitive dysfunction according to the Montreal Cognitive Assessment Scale (MoSA) patients were divided into 2 groups: 240 patients with cognitive decline (≤25 point by MoCA) and 50 patients without it. In order to verify the markers, anamnestic characteristics were assessed, cognitive-functional indicators (according to the scales of the National Institutes of Health, MoCA, Bartel, Rankin, IQCODE questionnaire, additional scales to assess praxis, semantic aphasia, perception and executive function), data of neuroimaging studies. For statistical analysis machine learning algorithms and Python with its libraries (Pandas and SciPy) were implied.

Results. The main neuropsychological indicators for patients with early post-stroke cognitive impairment were decline in the areas of perception, executive function, memory and semantic information processing, affective disturbances and physical fatigue. Relevant indicators identified during estimation of the instrumental and clinical examination results were severity of IS, left frontal and right parietal localisations of ischemia focus, presence of cortical atrophy and leukoaraiosis.

Conclusion. Based on multi-factor analysis of clinical and paraclinical parameters using machine learning algorithms, the main markers of cognitive decline of early post-stroke impairments were identified. This will allow us to optimise the choice of neurocognitive rehabilitation strategies and to personalise the approach in the further management of the stroke patient.
Back pain: diagnostic and therapeutic algorithms in outpatient practice
Authors: Shostak N. A. , Novikova A. V. , Pravdyuk N. G. , Shemetov D. A.
Published: September 2024

Back pain is a common reason for seeking primary care from older and younger people. Early spinal imaging by a therapist is indicated to eliminate potentially dangerous causes of pain. Independent magnetic resonance imaging or computed tomography examination at the patient’s initiative in the absence of “red flags” back pain in most cases does not come close to identifying the obvious cause of pain syndrome, and it creates the preconditions for the formation of an exaggerated picture of the disease in the patient himself, driving him into the “trap” of chronic pain. Attention of the polyclinic doctor to the clinical symptoms detailed in the article, following the standard algorithms of diagnosis will allow timely suspicion of “red flags” back pain, avoid hyperdiagnosis of the cause, and minimize the risk of its chronization. The algorithm for treatment of acute and chronic episodes of pain should include informing the patient about the favorable outcome in the vast majority of cases, optimizing the physical activity of the patient, the use of complex drug therapy, the basis of which are nonsteroidal anti-inflammatory drugs (predominantly selective), muscle relaxants and other pathogenetically based medicines.
Immune thrombocytopenia: literature review
Authors: Zakharov S. G.
Published: September 2024

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a decrease in platelet count, which often leads to bleeding. Evidence suggests that low platelet counts in ITP are the result of multiple factors, including impaired thrombocytopoiesis and changes in the immune response leading to platelet destruction. ITP is a heterogeneous disease with a course that is difficult to predict. In a significant number of cases, ITP becomes chronic, requiring long-term maintenance treatment, which leads to an increased risk of hemorrhagic complications and a decrease in quality of life. A deeper understanding ofthe etiology and pathogenesis ofthis disease makesit possible to identify potentialtherapeutic targets for the development of new effective treatments. This review summarizes recent advances in understanding the ITP pathophysiology, evaluating current therapeutic strategies and methods for predicting therapy response.
Influence of baseline telomere length on the results of immunosuppressive therapy in aplastic anemia patients
Authors: Luchkin A. V. , Mikhailova E. A. , Galtseva I. V. , Fidarova Z. T. , Abramova A. V. , Davydova Yu. O. , Kapranov N. M. , Nikiforova K. A. , Tsoy Yu. A. , Kulikov S. M. , Parovichnikova E. N.
Published: September 2024

Background. Acquired aplastic anemia (AA) is a non-tumor disease of the blood system and the pathogenesis is based on immune dysregulation directed against own hematopoietic stem cells, which leads to the development of bone marrow aplasia. Some modern research is directed to the study of intrinsic defects of hematopoietic stem cells, and one of which is the change in telomere length. Several large studies have shown the association of telomere shortening in AA patients with decreased overall survival, poor response to immunosuppressive therapy (IST), high rates of relapse and clonal complications.

Aim. To study the influence of the initial telomeric DNA regions length in AA patients on the disease course.

Materials and methods. 43 adult patients with acquired AA without previous pathogenetic therapy were included in the study. IST was performed according to a standard protocol including the use of hATG and cyclosporine. Flow-FISH was used as the method for measuring relative telomere length, and peripheral blood mononuclear cells were used as the study material.

Results. Telomere length determined before IST did not differ between non-severe and severe AA, but there were significant differences depending on disease duration (p = 0.032). Initially short telomeres correlated with a lower rate of achieving hematologic improvement (53 % vs. 80 %; p = 0.059). In addition, significantly worse results were obtained in achieving partial and complete remission in patients with initially short telomeres compared to those with initially long telomeres (37 % vs. 62 % and 5 % vs. 23 %, respectively; p <0.05). There was a tendency to increase the frequency of new chromosomal aberrations in patients with shorter telomere length.

Conclusion. The results obtained do not contradict previous studies and show the association of a decrease in baseline telomere length with poor response to IST and a high risk of clonal complications. The determination of telomere length should be used both in differential diagnosis between the acquired disease and congenital bone marrow failure syndromes, and for timely choice of patient management tactics (IST or allogeneic hematopoietic stem cell transplantation).