bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Theory of Truth in Countering Hoaxes Regarding Covid-19
Authors: Safitri Ria , Rahmadany Indira , Iswanto Aliefia , Pandin Moses Glorino Rumambo
Published: January 2022

Indonesia is one of the countries experiencing the COVID-19 pandemic. This causes anxiety for the Indonesian people which makes information about COVID-19 becomes crucial. Objective: This research was conducted with the aim of studying philosophical theories that can play a role in the process of testing information in warding off hoaxes about COVID-19. Researchers want to know whether the theory of philosophy of science can be of assistance to the public in recognizing and rejecting hoax news about COVID-19. Methods: The research was conducted using a descriptive verification method with a qualitative approach. The data from this study were taken from interviews and secondary data was taken by studying the literature. Interview data were taken with the target respondents, namely people in Surabaya with an age range of 25-40 years or what is often referred to as generation Y or millennials. The criteria for determining the number of respondents were taken until the researcher found a saturated sample. Meanwhile, the literature study data consists of 2 books, 37 articles, 1 website, and 1 report on the results of a national survey. Results: This study found 5 types of theory of truth, namely coherence theory, correspondence theory, pragmatic theory, consensus theory, and performative theory, each of which has a use in identifying hoaxes around COVID-19. Research Recommendation: Further research needs to be conducted which can test the actual practice of applying truth theories in countering hoaxes in the community at a certain scale. Limitations: This research has little chance of being applied by some Indonesians, given their low level of digital literacy and willingness to seek information.
Analysis of instagram's influence on cyber literature among millenial generation
Authors: Hidayati Nur
Published: January 2022

This research covers Instagram social media problems that have an impact on the development of cyber literature among the millennial generation. In the digital era that is growing rapidly, communication technology cannot be damned. Today's technology is certainly inseparable from the human need to communicate and socialize. The development of global technology allows a change in human lifestyle in socializing, which was limited initially to interpersonal communication through face-to-face. Still, it is now developing by utilizing communication media such as smartphones or through other social media such as WhatsApp, Facebook, Twitter, or Instagram, which allows users to be registered on a site. Service-based to create profiles. This study aimed to determine the influence of Instagram social media on cyber literature among the millennial generation. This study will use data analysis through observations and references to previous research as a reference by comparing, analyzing, and then combining them before being used to complete the material for this research. The author will describe the results of observations regarding the millennial generation in dealing with the phenomenon of cyber literature, which is facilitated through the social media Instagram.
EFEKTIVITAS KALIMAT DALAM TEKS EKSPOSISI SISWA KELAS X SMA NEGERI 2 LUBUK BASUNG
Authors: Fitria Ardina
Published: January 2022

Proposal penelitian mengenai " EFEKTIVITAS KALIMAT DALAM TEKS EKSPOSISI SISWA KELAS X SMA NEGERI 2 LUBUK BASUNG" meneliti kalimat efektif pada siswa kelas X SMA Negeri 2 Lubuk Basung, serta melihat hasil karya siswa terhadap struktur teks eksposisi.
Javandra.19421066.Cloud Computing.4
Authors: Savinsaka Javandra
Published: January 2022

tugas cloud computing
Proposal Penelitian Metodologi Penelitian Bahasa Indonesia
Authors: Zahirah Zahra
Published: January 2022

Berisi penjelasan mengenai hubungan antara keterampilan menyimak dengan keterampilan berbicara siswa kelas X SMA Negeri 8 Padang.
Javandra.19421066.sister.3
Authors: Savinsaka Javandra
Published: January 2022

tugas cloud computing
Market Volatility, Digital Transformation and Innovation changed the way of competition
Authors: Wijenayaka Amal
Published: January 2022

The world is rapidly changing. As a result, organizations have to find new ways to compete with close competitors. It is challenging to use traditional methods and ways. Advertising and price war are not gaining sustainable competitive advantage further. Most past researches mentioned that Innovation is the key to future success. Furthermore, it is required to transform to digitalization. It provides new insight into the organization. Market volatility is a huge challenge to the organization. However, it can be managed with digitalization and Innovation.
The Influence of Imperfect Film Moral Values on Society Regarding Body Shaming Problems in the Digital Era
Authors: Muarifah Risa
Published: January 2022

In this digital era, body shaming is increasingly prevalent on social media. Body shaming is the behavior of giving negative comments about a person's physical condition. Meanwhile, film is one of the mass media that is used as a medium of entertainment, information, and education to the public. In this case, we, the authors, examine the influence of the moral values of imperfect films on people's views in the digital era. The methods we use are observational methods and literacy studies. The result of this research is a film, especially in this case, imperfect films can be able to introduce or educate the public about the issue of body shaming that occurs in life in the digital era. The suggestion from this research is that the film industry in Indonesia should be more advanced in making positive works that can inspire and educate the public.
PERKAWINAN ANGKAP PADA MASYARAKAT GAYO DI KABUPATEN ACEH TENGAH DENGAN BERLAKUNYA UNDANG-UNDANG NOMOR 1 TAHUN 1974 TENTANG PERKAWINAN
Authors: safitri Dian
Published: January 2022

PERKAWINAN ANGKAP PADA MASYARAKAT GAYO DI KABUPATEN ACEH TENGAH DENGAN BERLAKUNYA UNDANG-UNDANG NOMOR 1 TAHUN 1974 TENTANG PERKAWINAN
[PREPRINT] Mind the Machines: Applying Implicit Measures of Mind Perception to Social Robotics
Authors: Li Zhenni , Terfurth Leonie , Woller Joshua Pepe , Wiese Eva
Published: January 2022

Beyond conscious beliefs and goals, automatic cognitive processes shape our social encounters, and interactions with complex machines like social robots are no exception. With this in mind, it is surprising that research in human-robot interaction (HRI) almost exclusively uses explicit measures, such as subjective ratings and questionnaires, to assess human attitudes towards robots - seemingly ignoring the importance of implicit measures. This is particularly true for research focusing on the question whether or not humans are willing to attribute complex mental states mind perception, such as agency (i.e., the capacity to plan and act) and experience (i.e., the capacity to sense and feel), to robotic agents. In the current study, we (i) created the mind perception implicit association test (MP-IAT) to examine subconscious attributions of mental capacities to agents of different degrees of human-likeness (here: human vs. humanoid robot), and (ii) compared the outcomes of the MP-IAT to explicit mind perception ratings of the same agents.Results indicate that (i) already at the subconscious level, robots are associated with lower levels of agency and experience compared to humans, and that (ii) implicit and explicit measures of mind perception are not significantly correlated. This suggests that mind perception (i) has an implicit component that can be measured using implicit tests like the IAT and (ii) might be difficult to modulate via design or experimental procedures due to its fast-acting, automatic nature.
When do languages use the same word for different meanings? The Goldilocks Principle in colexification
Authors: Brochhagen Thomas , Boleda Gemma
Published: January 2022

Lexical ambiguity is pervasive in language, and often systematic. For instance, the Spanish word "dedo" refers to both a toe and a finger, and this TOE-FINGER ambiguity is found in over 100 languages. Previous work shows that systematic ambiguities involve related meanings. This is attributed to cognitive pressure towards simplicity in language, as it makes lexicons easier to learn and use. The present study examines the interplay between this pressure and the competing pressure for languages to support accurate information transfer. We hypothesize that ambiguity follows a Goldilocks principle that balances the two pressures: meanings are more likely to attach to the same word when they are related to an optimal degree ---neither too much, nor too little. We find support for this principle in data from over 1200 languages and 1400 meanings. Our results thus suggest that universal forces shape the lexicons of natural languages.
Wider, faster, more: Re-envisioning the treatment and research of depression to address its public health burden in the United States
Authors: Lorenzo-Luaces Lorenzo
Published: January 2022

Depression and other internalizing disorder symptoms are leading causes of disability in theUnited States. Although there are effective interventions, the burden of disability attributableto internalizing disorder symptoms is not decreasing. I review clinical and epidemiological datato identify solutions to the public health burden of internalizing disorder symptoms. Contemporary research efforts have a focus on treatment development and the identification of biomarkers of response. However, these solutions are not scalable because internalizing disorders are much more common than usually appreciated and there are substantial disparities in access to mental health care. Improving the dissemination of individual interventions may also be of limited value given data suggesting that high rates of symptom remission can only be achieved with multiple (e.g., 4-10) treatment steps. The logic of stepped care approaches for internalizing disorders is well-supported by these data, but initial treatments likely should be low-intensity and “stepping up” should occur more quickly than usually done in most trials. Efforts that promise to make an impact in the public health burden of internalizing disorder symptoms need to consider their high prevalence and heterogeneity in the level of care as well as in the mechanisms that treatments may need to engage.
Causal surgery under a Markov blanket
Authors: Yon Daniel , Corlett Philip R.
Published: January 2022

Bruineberg et al provide compelling clarity on the roles Markov blankets could (and perhaps should) play in the study of life and mind. However, here we draw attention to a further role blankets might play: as a hypothesis about cognition itself. People and other animals may use blanket-like representations to model the boundary between themselves and their worlds.
Generational differences in income trajectories in the Nordic welfare state
Authors: Karonen Esa , Lehti Hannu , Erola Jani , Kuivalainen Susan , Moisio Pasi
Published: January 2022

How much it matters for your income development what generation you happen to be born? We answer this question by using registers of the total population, we study generational income inequality during 1970–2018 and, for men and women in Finland. We follow the income trajectories of the cohorts born in 1920–1983 over their adult life course and observed, how certain structural factors explain differences in income trajectories. Our study expands state-of-the-art knowledge, as previous research has often bypassed the question of how much generational income differences explains of populations total income inequalities and what factors may explain the different generational income trajectories. Results show that overall generational income differences explained quarter for women and 6 percent for men total income inequality. Each successive cohort until 1980s had a higher average income trajectory. However, generation born in the 1980s has been falling behind. For both men and women, age structure and education were the most important factors associated with income inequality. On contrary to previous findings on Nordic welfare state, our results also indicate that, generational income trajectories are affected by economic shocks.
Role of Psychology Treatment in "Anxiety Disorder"
Authors: Dr. Mahesh Kumar Gajurel
Published: January 2022

In order to manage the emotional and psychological problems in special population such as mental retardation. HIV positive cases and so on. A comprehensive management of this type of cases includes psychotherapy. Here it is necessary to know about this concept and its beauty in various disorders. It is a psychological method which is called psychotherapy (Talking Cure). Psychotherapy is a systematic attempt to manage the mental and emotional disorders with the help of psychological means a variant of this approach came in 1960s. Which was called cognitive behavior therapy. Recent days this approached has been brought revolution in management of psychological, behavioral and emotional problems. This paper will enhance our knowledge regarding status of psychological method in various disorders and mental illnesses.
Cernea's classification of the External Branch of the Superior Laryngeal Nerve during Microscopic Thyroidectomy at Gandaki Medical College, Pokhara
Authors: Dubey Tulika , Sigdel Brihaspati , Nepali Rajendra , KC Neeraj
Published: January 2022

Background: Preservation of the external branch of the superior laryngeal nerve (EBSLN) during thyroidectomy is important because its injury may lead to frequent occurrence of vocal fatigue and the inability to perform phonation. The objective of the study was to identify and classify the nerve as per Cernea's classification using operating microscope during thyroidectomy
Method: Between January 2017 to December 2019, we evaluated 50 patients for the position of external branch of superior laryngeal nerve, who underwent microscopic thyroid surgeries in the department of ENT- head and neck surgery at Gandaki Medical College.
Results: In our study, we dissected a total 59 superior poles of thyroid from 50 patients and identified the nerve in all the cases. Of the total superior poles, 36 (61.01%) had type IIa EBSLN among which 24 was on the right side and 12 on the left followed by 19 (32.20%) patients with type IIb EBSLN among which 8 on right and 11 on left side. There were only 4 poles (6.77%) of type I with 3 on the right and 1 on the left side.
Conclusion: The EBSLN can be very efficaciously identified during a microscope assisted thyroidectomy. Cernea type 2a and 2b EBSLNs are in position to be at high risk of injury during ligation of the superior vascular pedicle, which can be avoided by prompt identification through a microscope and a meticulous extra capsular dissection technique.
Histopathology of Polyps and Cancer of Colorectum: A ten years study from a tertiary care center
Authors: Goyal Binita
Published: January 2022

Introduction and objectives: Polyps and colorectal cancer have overlapping clinical presentation and may be difficult to diagnose on clinical grounds alone and close clinicopathological correlation is required for correct diagnosis and management. This study was aimed to see the spectrum of polyps and cancer in colorectum, see the percentage of colorectal cancer in younger individuals, see association between histologic grade and pathologic stage at presentation and compare site of tumor and pathologic stage at presentation in younger and older age group.

Methods: This study was carried out on 138 consecutive cases of polyps and malignant lesions of colorectum during a time period of 10 years from January 2011 to December 2020.

Results: Age of the patients ranged from 2 – 90 years with mean 45.1 years and a male female ratio 2:1. There were 58 (42.0%) cases of polyps and 80 (58.0%) cases of malignancies. 37 (46.3%) malignancy cases were seen in individuals ≤ 50 years of age. Most common site of involvement was rectum in 80 (58.0%) cases. Most common non-neoplastic polyp was retention polyp comprising 25 (67.6%) and most common neoplastic polyp was adenoma comprising of 18 (85.7%) cases. Most common malignancy was adenocarcinoma comprising 75 (93.8%) cases.

Conclusion: Significant number of malignancies is seen in younger individuals stressing the need for suspicion and surveillance in this age group. Histologic grade is an important prognostic parameter and there is no difference in site of tumor and stage at presentation between younger and older age group.
Prevalence of partial edentulism among the patients visiting a Tertiary Health Care Center in the Western Region, Nepal
Authors: Manandhar Pratik , Ranjit Rebicca , Tuladhar Sapna Laxmi , Bhandari Arjun
Published: January 2022

Introduction: Tooth loss causes impairment, functional limitation, physical, psychological, and social disability.  Hence, the study of pattern of tooth loss can provide a rough information about the frequency, cause and magnitude of oral problems, its sequelae that eventually can act as mirror image of prosthodontic treatment needs. 

Objectives: To assess the prevalence of partial edentulism and its etiology, to determine its association with sociodemographic parameters, and to find out the motivational factor/s for replacement in willing patients.

Methods: Total 417 patients with partial edentulism were examined intraorally on the basis of Kennedy’s classification with Applegate’s modification. The descriptive analysis was done using frequency distribution. Pearson Chi-square analysis test was used to determine the association between demographic variables and type of tooth loss where p-value ≤0.05 was considered statistically significant.

Results: Partial edentulism was more prevalent in mandibular arch (41.7%) followed by both arches (30.9%). Kennedy’s Class III was the commonest and Kennedy’s class III modification 1 was second most common type of partial edentulism. Age and educational status had statistically significant association while gender had no association with various classes of partial edentulism. Dental caries (62.8%) followed by periodontitis (25.9%) were the major causes of tooth loss. Functional demand (46.8%) was the key motivational factor for the replacement among those who were willing (78.4%).

Conclusions: This study can help in assessing the epidemiological features of partial edentulism of one community in a more classified form and can help gather information necessary to assess the treatment needs.
A study of height, weight and body mass index in Nepalese
Authors: Baral Prakash , Shrestha Rami , Shrestha Ratindra Nath , Banstola Dinesh , Prajapati Rajesh
Published: January 2022

Introduction: The height measurement is an important anthropometric measurement which can be directly correlated with health status of an individual. Body weight of an individual refers to total body mass and is also important indicator of health status of people. Body mass index (BMI) is a key index for relating weight to height. It is defined as the body mass divided by the square of the body height, The BMI is an attempt to quantify the amount of body tissue mass  in an individual, and then categorize that the person as underweight, normal weight, overweight or obese.
Objectives: To find out the average height and weight, to calculate BMI and find out its average value and to correlate height and weight in Nepalese population.
Methodology: A cross sectional study was conducted in subjects from different parts of Nepal. Three hundred twenty one healthy subjects of 25-40 years of age group were studied. Height and weight of subjects were recorded and BMI was calculated. Data were analyzed using SPSS.
Result: In overall Nepalese population, Mean height was found to be 156.6 ± 6.3 cm; mean weight 56.6 ± 11.4 kg and BMI 20.9 ± 1.8 kg/m2. Pearson’s correlation co-efficient(r) for height and weight was 0.88.
Conclusion: There was partial positive correlation between height and weight. There was statistically significant difference in height, weight and BMI between Nepalese male and female(p<0.05).
Role of telemedicine and its implementation in Nepal
Authors: Subedi Krishna , Subedi Nuwadatta
Published: January 2022

No abstract
De los datos léxicos y de los textos que los contienen. A propósito del futuro próximo de la filología
Authors: Pascual Rodríguez José A.
Published: January 2022

From the current situation of data in the philological work, a scenario is described of how things could look in the near future. In that scenario, data could go from being indications to becoming arguments in the study of the history of words. In order for that to take place, a good codification of texts (also linguistically speaking) is needed, so as to create models to be applied to the different possibilities of interpreting words.
Introduction
Authors: Gross Gaston
Published: January 2022

Neophilologica. Vol. 33 (2021): Perspectives pour la linguistique et autres études.
EFFECT OF STEEL FIBER PROPORTION ON SIFCON MECHANICAL PROPERTIES
Authors: A. Hamed Haneen , W. Abass Zinah
Published: January 2022

Slurry Infiltrated Fiber Concrete (SIFCON) is a relatively new high-performance material that may be thought of as a high-fiber content version of fiber reinforced concrete. This matrix is comprised of flowing mortar that must penetrate the fiber network implanted in the molds sufficiently. SIFCON combines excellent mechanical properties with a high ductility and toughness grade. SIFCON is utilized in applications that demand a high degree of ductility and energy absorption, most notably seismic-resistant reinforced concrete structures and structures exposed to abnormal or explosive loads. Additionally, pavement overlays, prestressed beam repair, and structural reinforced concrete element restoration have all been effective. The main aim of this study is to determine the effect of hooked-end steel fiber and micro-steel fiber on the strength of SIFCON specimens exposed to flexural and splitting loading. Three volume fractions of steel fiber (8,10, and12) % were used in this investigation. By weight of cement in SIFCON slurry, the proportion of Silica Fume SF substitution was 10%. Flexural strength was determined by testing specimens of (100×100×500) mm, and splitting tensile strength was determined at 7 and 28 days using cylindrical specimens with dimensions (150mm × 300m).. The results obtained from these tests were compared with SIFCON containing micro steel fiber. The test results show superior characteristics of SIFCON containing hooked-end steel fiber, as compared with micro steel fiber. For example, the flexural strength and splitting strength are 24.89 MPa and 10.14 MPa, respectively for SIFCON with 8% hooked-end steel fiber and 17.51 MPa and 9.1 MPa for control specimens with micro steel fiber.
Dyskretny urok burżuazji u schyłku wielkiego konania. Czas, pamięć i cywilizacja w dwóch powieściach Tomasza Manna – Buddenbrookowie. Dzieje upadku rodziny oraz Czarodziejska góra
Authors: Zakrzewska Ewa
Published: January 2022

The paper aims to juxtapose and compare the notions of temporality, memory and civilization in Thomas Mann’s two seminal novels: Buddenbrooks and The Magic Mountain. It sheds light on a range of Mann’s topics and motives, such as the tension between cyclic and linear time in the bourgeois milieu, the artefact mediated memory, the unobvious relationship of familial and social history and the role that fate plays within them, possible concepts of temporality in a metaphorically ill and weakened civilization. These analyses serve the aim of sketching out a philosophy of history which Mann tacitly but steadily employs throughout his oeuvre.
Rewokacje antyczne w poezji Wacława Iwaniuka
Authors: Stabryła Stanisław
Published: January 2022

The recallings to antiquity in Vaclav Iwaniuk’s poetry assume the reinterpretations in most cases. The above review of the mythological and historical motifs taken from the Greek or Roman antiquity allows us to conclude, first of all, that they were brought up to date owing to the use of the method we have called a reinterpretation. The poet, referring to the Greek myth or the history, tried to find the patterns and the symbols that make it possible to understand the history of his nation, its past and present situation, and his own life and fate.
Watching Movies in Jonestown: A Cultural Interlocutor Approach to Visual Media and New Religions
Authors: Klippenstein Kristian
Published: January 2022

This article argues that new religious movements (NRMs) develop as cultural interlocutors. As emergent social bodies that respond to extant norms, structures, and values, NRMs can deploy cultural products as a shared vocabulary and grammar in their response to surrounding society. To demonstrate this approach’s ability to parse NRMs’ relations to popular culture while highlighting organizationally distinctive dimensions of such interactions, this article examines Jim Jones’s references to visual media shown in Jonestown in 1978. Jones critiqued movies and television as tools of social control, repurposed documentaries and films as evidence to support his proffered doctrine, and creatively presented movies as analogues of the commune’s perceived challenges. This threefold hermeneutic shaped the Peoples Temple’s beliefs and behavior, as well as its own media productions.
Lifestyle Modification Therapy in Diabetes Disease: A Review Article
Authors: Putra Gofur Nanda Rachmad , Putri Gofur Aisyah Rachmadani , Soesilaningtyas Soesilaningtyas , Putra Gofur Rizki Nur Rachman , Kahdina Mega , Martadila Putri Hernalia
Published: January 2022

Introduction: Diabetes mellitus (DM) is a metabolic disease characterized by high blood glucose levels (hyperglycemia) resulting from disturbances in insulin secretion, insulin action or both. Insulin is a hormone produced by pancreatic beta cells, which is needed to utilize glucose from digested food. Comprehensive care is taken to treat patients with either prediabetes or diabetes. Diabetes management includes lifestyle interventions along with pharmacologic therapy and routine blood glucose monitoring. So that a decrease in blood glucose can occur and can be stable for a long time. Discussion:Lifestyle modification is an economical treatment that saves costs to prevent or delay the onset of diabetes. On the other hand, nutritional management provided by a dietitian is also recommended. Moderate weight loss goals are an important component of diabetes prevention and treatment, as large body weight can increase blood glucose levels, and can also have an increasing impact on blood pressure and cholesterol levels. Weight loss can be achieved through a balanced diet, with total control of calories and free carbohydrates. However, for diabetic patients following a low-carbohydrate diet, they should be informed about possible side effects such as hypoglycemia, headaches and constipation. Other studies have suggested the consumption of complex dietary fiber and whole grains to improve blood sugar control. Greater adherence to diet combined with light physical activity was associated with a lower likelihood of diabetes after adjusting for various factors. Conclusion:Lifestyle modification is a fairly cost-effective treatment to prevent or delay the onset of diabetes, with a risk reduction of about 58% in 3 years. It is strongly recommended by the ADA that patients with IGT, IFG or HbA1C levels of 5.7-6.4% be counseled on lifestyle changes such as diet and exercise. On the other hand, nutritional management provided by a dietitian is also recommended.
Biology of increased tolerance and validation of the psychoactive substance dependence
Authors: Baitubayеv D.G.
Published: January 2022

The article shows that the current level of physiology does not disclose the biological mechanisms of the organism transition from one range to adapt to a higher with an increase in the regular forces of the stimulus above sub-extreme. A new trend in the physiology of adaptation - proqredient adaptation, explains the mechanism of increasing the tolerance of the organism, with dependence on psychoactive substances (PAS ). It is scientifically proved, that dependences of the organism on PAS are the states of progredient adaptation.
Nanostructures of Phospholipids on Articular Cartilage Surface and their Functions
Authors: Pawlak Pawlak , Sojka M.
Published: January 2022

Phospholipids bilayers fulfill an important role in natural joint lamellar-repulsive lubrication mechanism. Low friction between surfaces coated with negatively charged the phospholipid headgroup (–PO4-) as being due to a hydration layer. Wettability of the cartilage surface depends on the number of PLs that act as a lubricant. The cartilage can be classified as a group of intelligent material, which in the wet state has a contact angle of ~0º, and the air-dry state has a contact angle of ~104º.
Conduction System Pacing: Basis and Scope
Authors: Kumar DR Vivek , Arora DR Vanita
Published: January 2022

Long-term right ventricular pacing (RVP) is associated with more cardiovascular death, atrial fibrillation (AF), thromboembolic complications and heart failure(HF). RVP often results in prolonged QRS duration(QRSd) and ventricular desynchronization. The ventricular desynchronization as a result of RVP leads to an increased risk of heart failure hospitalization (HFH) and AF, and this effect is dependent on cumulative percent ventricular paced ( % VP). In the sub-study from the MOST trial, it was evident that % VP >40% was associated with a 2.6-fold increased risk of HFH compared with pacing < 40% of the time despite preserved atrioventricular synchrony. Moreover this adverse effect of RVP induced ventricular desynchrony was more pronounced in patients with left ventricular ejection fraction( LVEF) of 40% or less resulting in increased death or HFH.
Tips and Tricks in Cardiac Surgical Anesthesia
Authors: Gokalp TAS Hakan , Degirmenci Hüsnü
Published: January 2022

For operations including coronary artery by-pass grafting (CABG), heart valve repair or replacement, ascending aorta surgeries, heart transplantation, and surgical correction of congenital heart defects, anesthesia management shares many similar concepts
Clinical Pharmacology of Sildenafil in Infants and Children
Authors: Pacifici Gian Maria
Published: January 2022

Sildenafil is a competitive and selective inhibitor of phosphodiesterase 5. Sildenafil is cleared by hepatic CYP3A (major route) and CYP2C9 (minor route) and concomitant administration of potent CYP3A inducers (e.g., bosentan) causes decreases in plasma levels of sildenafil. CYP3A4 inhibitors (erythromycin and cimetidine) inhibit sildenafil metabolism prolonging the half-life and elevating blood levels of sildenafil. Sildenafil is a pulmonary arterial vasodilator and it has been used in the treatment of persistent pulmonary hypertension. The initial oral dose is 250 to 500 µg/kg 4 times-daily in infants and the oral dose is 10 to 20 mg thrice-daily in children with a body-weight up to 20 kg or > 20 kg, respectively. Sildenafil has been found efficacy and safe in infants and children but it may induce adverse-effects. Following an oral dosing, the absorption rate constant is 0.343 h-1, and the elimination half-life is 2.41 hours in children suggesting that sildenafil is rapidly absorbed and eliminated. The interaction of sildenafil with drugs and the metabolism of sildenafil have been extensively studied. The principal routes of sildenafil metabolism are: N-demethylation, oxidation, and aliphatic dihydroxylation, and the major metabolite is N-desmethyl sildenafil. The treatment of infants and children with sildenafil has been extensively studied. Sildenafil citrate and sildenafil cross the human placenta and sildenafil migrates into the breast-milk in significant amounts. The aim of this study is to review the sildenafil dosing, efficacy and safety, effects, adverse-effects, pharmacokinetics, interaction with drugs, metabolism, treatments, and sildenafil placental transfer and migration into the breast-milk.
Tocilizumab and Mortality in Hospitalised Patients with Covid-19. A Systematic Review Comparing Randomised Trials with Observational Studies
Authors: Qizilbash Nawab , Podmore Bélène , Lacetera Alessandra , Ubillos Itziar , Andresen Kirsty , Roncero Martín Ana , Majuelos-Melguizo Jara , Cuñado Moral Ana , Hinojosa Campos Marina , K Aronson Jeffrey , Pocock Stuart
Published: January 2022

Background: Early observational studies suggested that tocilizumab might produce clinical improvement in covid-19 patients leading to the use of tocilizumab. Early underpowered randomised controlled trials (RCTs) however did not show benefit until the most recent largest trial. RECOVERY trial. We aimed to compare the evidence from RCTs and observational studies of the effect of tocilizumab on in-hospital mortality in patients with covid-19. Materials and Methods: Embase and PubMed were searched from July 2020 until 1 March 2021. Observational studies and RCTs assessing in-hospital mortality in patients receiving tocilizumab compared with standard care or placebo were included. The primary outcome was in-hospital mortality closest to 30 days. The risk of bias in observational studies was assessed using the ROBINS-I tool. A fixed effect meta-analysis was used to combine relative risks, with random effects and risk of bias as a sensitivity analysis. Results: Of 5,792 publications screened for inclusion, eight RCTs and 33 observational studies were identified. The RCTs showed an overall relative risk reduction in in-hospital mortality at 30 days of 0.86 (95% confidence interval (CI) 0.78 to 0.96) with no statistically significant heterogeneity. 23 of the observational studies had a severe risk of bias, 10 of which did not adjust for potential confounders. The 10 observational studies with moderate risk of bias reported a larger reduction in mortality at 30-days (relative risk 0.72, 95% CI 0.64 to 0.81) but with significant heterogeneity (P<0.01). Conclusion: This meta-analysis provides strong evidence from RCTs that tocilizumab reduces the risk of mortality in hospitalised covid-19 patients. Observational studies with moderate risk of bias exaggerated the benefits on mortality two-fold and showed heterogeneity. Collectively observational studies provide a less reliable evidence base for evaluating treatments for covid-19.
Design and Optimizations of Aceclofenac Bioadhesive Extended Release Microspheres
Authors: Prasad G. , Devika K. , Varshith P. , Shravani B. , Pavithra E. , Swathi Ch.
Published: January 2022

The oral route for drug delivery is the most popular, desirable, and most preferred method for administrating therapeutically agents for systemic effects because it is a natural, convenient, and cost effective to manufacturing process. Oral route is the most commonly used route for drug administration. Although different route of administration are used for the delivery of drugs, oral route remain the preferred mode. Even for sustained release systems the oral route of administration has been investigated the most because of flexibility in designing dosage forms. Present controlled release drug delivery systems are for a maximum of 12 hours clinical effectiveness. Such systems are primarily used for the drugs with short elimination half life.
Hybrid Sorbents for Removal of Arsenic
Authors:   Institute of Chemistry, Far Eastern Branch, Russian Academy of Sciences, Zemskova L. , Shlyk D. ,   Institute of Chemistry, Far Eastern Branch, Russian Academy of Sciences, Barinov N. ,   Far Eastern Geological Institute, Far Eastern Branch, Russian Academy of Sciences
Published: January 2022

The paper analyzes data on the removal of arsenic by sorption methods using materials that have prospects for large-scale application in water treatment. These materials include transition metal oxides in the micro- and nano-dimensional form, including those in the composition of composite materials with inorganic matrices, or hybrid sorbents in the composition with polymer resins or natural biopolymers. Examples of the use of composite (hybrid) sorbents for the removal of arsenic from solutions with low concentrations (at the level of MPC) are given. The objective of this article was to sum the up-to-date information about the most important features of chitosan-containing and chitosan-carbon materials we developed in view their use in arsenic removal processes at low concentrations to concentrations that meet WHO requirements. The paper presents data on the sorption properties of Mo-containing activated carbon fibers and chitosan-carbon composite materials towards arsenic (V) when it is extracted from bidistilled and tap water under static and dynamic conditions. The factors of the different behavior of the sorbents depending on the form of a biopolymer deposited on the fiber and the stability of the sorbents during the sorption of arsenic are discussed.
Study of the horizontal sidetracking efficiency using hydrodynamic modeling (on the example of a Kazakhstani field)
Authors:   Satbayev University, Soltanbekova K. , Assilbekov B. ,   Satbayev University, Zolotukhin A. ,   National University of Oil and Gas “Gubkin University”
Published: January 2022

One of the modern approaches for the effective development of small deposits is the construction and operation of wells with a complex architecture: horizontal wells (HW), sidetracks (BS, BGS), multilateral wells (MLW). Sidetracking makes it possible to reanimate an old well that is in an emergency state or inactivity for technological reasons, by opening layers that have not been previously developed, bypassing contamination zones, or watering the formation. This study examines the possibility of using horizontal sidetracks in the operating wells of the field of the Zhetybai group. To select the optimal length of the horizontal sidetrack of the wells, graphs of the dependences of the change in flow rate versus length of the horizontal well were built, taking into account the pressure losses due to friction. It can be seen from the dependence of NPV versus length of the horizontal wellbore that the maximum NPV is achieved with a horizontal wellbore length of 100 m. A further increase in the length of the horizontal wellbore leads to a decrease in NPV. This is due, firstly, to a decrease in oil prices, and secondly, interference of wells, a small number of residual reserves, and a small oil-bearing area. As a result of a comparison of technical and economic criteria, the optimal length of a horizontal wellbore is from 100-300 meters. Comparison of the flow rates of vertical wells and wells with horizontal sidetracks showed a clear advantage over the latter in all respects.
A infância em O pequeno polegar sob o olhar de Robert Darnton
Authors: Milhomem de Moura Rodrigo
Published: January 2022

Este trabalho tem por objetivo discutir a infância em O Pequeno Polegar sob o olhar de Robert Darnton. Para isso, amparamo-nos nas problematizações de história da infância (HEYHOOD, 2004); contos orais como documentos e fontes históricas (DARNTON, 1986); infância e literatura (AMARILHA, 2000). O tipo de pesquisa utilizado é o bibliográfico e a abordagem é a qualitativa. Na análise do conto, observamos que a infância predominante é a camponesa: pobre, miserável e abandonada. Devido a esse contexto problemático e miserável, é necessário que artefatos ou seres mágicos apareçam para tirar as famílias camponesas de suas situações degradantes.
“Formas da impertinência” na literatura brasileira contemporânea: Delírio de damasco, de Verônica Stigger
Authors: Dias Giselia Rodrigues
Published: January 2022

Este trabalho objetiva analisar a obra ficcional Delírio de Damasco, de Veronica Stigger (2012), a partir da noção de “impertinência” proposta por Florencia Garramuño (2014). Tendo em vista problematizar a noção de campos autônomos que já não consegue abarcar a cena literária contemporânea, a metodologia contempla os estudos teóricos/críticos de Josefina Ludmer (2010), Canclini (2016), Laddaga (2012), Shollhammer (2009), dentre outros. Espera-se que os resultados apontem para um diálogo com outras discussões já consolidadas sobre a obra em questão, bem como contribuam com os estudos que, nos últimos anos, vêm (re)pensando a expansão dos campos autônomos de atuação.
Optimización de proyectos de fuentes renovables de energía con Excel cuando no se dispone de software profesionales
Authors: Enríquez García Lorenzo Alfredo , García Faure Luis Jerónimo , Muñoz Cargua José Rigoberto
Published: January 2022

En ocasiones, para la realización de análisis de rentabilidad y proyectos con fuentes renovables de energía no se dispone de un software profesional, o no se corresponden los parámetros de entrada y de salida con los disponibles o deseados por el usuario pues el diseñador escoge los parámetros con los cuales ha de operar su algoritmo. Muchos proyectos como el que se presenta en este documento pueden ser diseñados por profesionales y estudiantes con un modesto conocimiento de computación y resueltos con la aplicación Excel presente en todos los paquetes de Microsoft Office. El ejemplo mostrado tiene como objetivo la determinación de los principales parámetros del anteproyecto, realizar los cálculos de rentabilidad y el análisis de sensibilidad de un sistema híbrido eólico-electrógeno que debe garantizar la demanda base de una red aislada. Se comparan los resultados con los obtenidos en el software profesional HOMER Beta V.2.68.
A compact guide to the systematic review and meta-analysis of the literature in neuroscience
Authors: Bolzan Juliana , Lino de Oliveira Cilene
Published: January 2022

Critical appraisals of the literature may help to increase reproducibility in neuroscience. Systematic reviews and meta-analyses are tools for neuroscientists to critically evaluate a large amount of knowledge in the research field. These methods involve individually simple decisions, which may become complex when considering the whole process. Strategies to organize the planning and implementation of the protocols minimize the workload. Here, we prepared a compact guide to assist neuroscientists willing to perform a systematic review and meta-analysis of the literature in neuroscience.
Vegetable by-products in the European food legislative framework
Authors: Knežević Nada , Ranilović Jasmina , Cvetković Tanja , Grbavac Slavka , Palfi Marina
Published: January 2022

Vegetable by-products are a source of many useful bioactive compounds, dietary fiber, fatty acids and proteins that have a great potential in the development of new food products and the promotion of the circular economy and sustainability.Considering processed pepper by-products as an example, the aim of this paper is to provide an overview of EU food legislation that should be taken into account before placing such products on the market, as well as of the voluntary labeling of functional, nutritional and sustainability benefits important for consumers.
Developing Green Tourism-Based Model of Information Technology Utilization in Tourism Villages
Authors:   Politeknik Negeri Bali, Sarja Ni Luh Ayu Kartika Yuniastari , Widana I Putu Krisna Arta ,   Politeknik Negeri Bali, Suprapto Putu Adi ,   Politeknik Negeri Bali, Pamularsih Tyas Rahajeng ,   Politeknik Negeri Bali
Published: January 2022

The purpose of this study is to develop a model for the use of information technology in Tourism Villages by mapping the use of information technology on all aspects of tourism villages based on the concept of green tourism that focuses on environmental preservation and community welfare. The method used in this research is an information research framework consisting of stages of literature review and environmental aspects, analysis, construct identification, model development, model evaluation, and model application methods. The results of the research are in the form of a model for the use of information technology in green tourism-based tourism villages along with the method of applying the model. This model consists of two connected constructs, namely the use of information technology and green tourism. The implementation of this model in tourist villages is explained in the method of applying the model which contains a mapping of information technology needs and implementation steps based on the classification of tourist villages, namely pioneering, developing, advanced and independent. This model can be used as a reference for tourism village managers in utilizing information technology according to their needs.
The Implementation of Green Housekeeping Management at The St. Regis Bali Resort
Authors:   Politeknik Negeri Bali, Setiawan I Gede Mangku , Triyuni Ni Nyoman ,   Politeknik Negeri Bali, Budarma I Ketut ,   Politeknik Negeri Bali, Antara Dewa Made Suria ,   Politeknik Negeri Bali
Published: January 2022

This research focuses on analyzing the implementation of green housekeeping management at The St. Regis Bali Resort. The data of the research was collected through observation, interview, questionnaires’ distribution, and documentation. The questionnaires were distributed to the 38 employees of the Housekeeping Department. Quantitative analysis was used to analyze the data. The research results using the frequency distribution of Likert scale with 5 (five) scales on the SPSS version 25.0 stated that the average value of the indicators related to the implementation of green housekeeping management on the questionnaire was a value of 4 or very well implemented. It is proved that the concept of green housekeeping management at The St. Regis Bali Resort has been implemented very well in the daily operations. It aims to preserve the environment, saving energy, and ensure maximum guest satisfaction.
Possible relationships of selected food items to osteoporosis among a group of Iraqi women
Authors: Saleh May fawzi , Aldiwan Jawad , Ahmed Ammar H.
Published: January 2022

Background: Osteoporosis is a global health problem which is estimated to affect more than 200 million people worldwide, especially postmenopausal women. It is characterized by decreased bone mineral density leading to fragility and increased risk of fractures.
 Objective: This study was conducted to explore the consumption of inappropriate foods related to osteoporosis among a group of Iraqi women.

JFac Med Baghdad
2021; Vol.63, No. 4
Received: Sep., 2021
Accepted: Nov., 2021
Published: Jan., 2021
 

Patients and methods: A cross sectional study of 140 females aged ≥ 40 years attending polyclinics in Al-Dora sector in Baghdad city from 18th January to 24th April 2021. The bone mineral density was measured by portable quantitative calcaneal ultrasound machine (osteosystem) and the bone was assessed for osteoporosis by T-score. Food frequency questionnaire was used for collecting data related to food consumption.
Results: Out of the total sample, 74 (52.9%) were found to be osteoporotic. There was a significant association with high salt and coffee consumption with the occurrence of osteoporosis (77.3% and 83.3%, respectively, p = 0.001), compared to those who did not consume caffeinated drinks. Participants with daily consumption of caffeinated drinks had a highly significant association with osteoporosis (21.8% vs 100%, p = 0.001).
Conclusion: Excessive consumption of salty foods and caffeinated beverages appears to exert a negative effect on bone mineral density and the occurrence of osteoporosis among the studied group of Iraqi women.