bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Efficacy and Acceptability of Cholinesterase Inhibitors and
Memantine Based on Dosage in Patients with Vascular Cognitive Impairment:
A Network Meta-analysis
Authors: Shi Xinxiu , Ren GuangHao , Cui Yang , Xu ZhongXin
Published: January 2022

Background:

Considering the lack of direct comparison between cholinesterase inhibitors
and memantine in patients with vascular cognitive impairment (VCI), determining how to choose the
best treatment plan remains inconclusive. Hence, we conducted the network meta-analysis to compare
the efficacy and acceptability of these drugs.

Methods:

PubMed, the Cochrane Central Register of Controlled Trials, Embase and Web of Science
were searched for double-blind randomized controlled trials (RCTs) for the treatment of VCI, which
involved donepezil, galantamine, rivastigmine, and memantine, from database inception to January 1,
2020. Then, a network meta-analysis based on the frequency method was conducted.

Results:

Eleven RCTs were included. Compared with the placebo, in terms of efficacy, donepezil 5
mg (standardized mean difference = -1.11, 95% confidence interval = -1.88 to -0.34), donepezil 10 mg
(-1.44, -2.31 to -0.56), galantamine 24 mg (-1.99, -3.03 to -0.95), and memantine 20 mg (-1.89, -2.93
to -0.86) were more effective for the cognition of ADAS-cog, and donepezil 5 mg (0.46, 0.12 to 0.81),
donepezil 10 mg (0.76, 0.34 to 1.17), and rivastigmine 12mg (0.60, 0.10 to 1.10) exhibited superior
benefits for the cognition of MMSE. Donepezil 10 mg (-0.25, -0.44 to -0.06; -1.47, -2.79 to -0.15) exhibited
improvements for CDR-SB and EXIT25, respectively. In terms of acceptability, memantine
was found to be the best.

Conclusions:

Donepezil 5 mg, donepezil 10 mg, galantamine 24 mg, memantine 20 mg, and rivastigmine
12 mg exerted beneficial effects on cognition, and donepezil 10mg provided beneficial effects for executive
function and global status. Based on the network meta-analysis, donepezil 10 mg might be the best
choice, considering the benefits on cognition function, executive function and global status, but doserelated
adverse reactions need to be noted. In the meantime, memantine is a better comprehensive choice
in terms of efficacy and safety.
The Impact of Uremic Toxins on Alzheimer's Disease
Authors: Zheng Yuqi , Ji Bin , Chen Sijun , Zhou Rong , Ni Ruiqing
Published: January 2022

Alzheimer's disease (AD) is the most common type of dementia, pathologically characterized
by the accumulation of senile plaques and neurofibrillary tangles. Chronic kidney disease (CKD) is
highly prevalent in the elderly population closely associated with the occurrence of dementia. Recent
epidemiological and experimental studies suggest a potential association of CKD with AD. Both diseases
share a panel of identical risk factors, such as type 2 diabetes and hypertension. However, the relationship
between CKD and AD is unclear. Lower clearance of a panel of uremic toxin including cystatin-
C, guanidine, and adiponectin due to CKD is implied to contribute to AD pathogenesis. In this review,
we summarize the current evidence from epidemiological, experimental, and clinical studies on
the potential contribution of uremic toxins to AD pathogenesis. We describe outstanding questions and
propose an outlook on the link between uremic toxins and AD.
Cytotoxic Effects of Garcinia mangostana Pericarp Extract on Cancer Cell
Lines
Authors: Mousavi Seyed Hadi , Rashidi Roghayeh , Forouzanfar Fatemeh , Soukhtanloo Mohammad , Ghasemian Shirin
Published: January 2022

Background:

Garcinia mangostana, commonly also called mangosteen, is an evergreen
tropical tree, and its pericarps have been used in traditional herbal medicine for different diseases.
The anticancer efficacy of the ethanolic extract from the pericarps of Garcinia mangostana was investigated
in human prostate cancer cells (PC3), melanoma cells (B16F10), breast cancer cells (MCF7),
and glioblastoma (U87) cell lines.

Methods:

3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay was used to
measure cell viability. Propidium iodide (PI) staining and analysis on a flow cytometer were used
to identify apoptosis. Action on cell migration was evaluated by scratch assay and gelatin zymography.
Furthermore, the level of intracellular reactive oxygen species (ROS), malondialdehyde (MDA),
glutathione (GSH), and superoxide dismutase (SOD) activity was measured. Moreover, we investigated
the synergistic efficacy with several combinations of Garcinia mangostana extract (GME)
with doxorubicin.

Results:

GME reduced cell viability in malignant cell dose time-dependently. GME-induced sub-
G1 peak in flow cytometry histogram of treated cells control representing apoptotic cell death is involved
in GME toxicity. Furthermore, GME exhibited inhibitory effects on the migration ability of
U87 cells, which was accompanied by inhibition in the activity and expression of MMP2 (matrix
metalloproteinase-2). Besides, GSH level and SOD activity were significantly reduced while there
was an increase in ROS and MDA concentration following 24 hr of GME treatment. Moreover, a
combination of GME (1.5–25 μg/mL) with Dox (6 μg/mL) displayed synergistic efficacy and cell
growth inhibition.

Conclusion:

In conclusion, GME could cause cell death in PC3, MCF7, U87, and B16F10 cell
lines, in which apoptosis plays an imperative role. Plant extract decreased the migration ability of
the cells by inhibiting the activity and expression of Matrix metalloproteinases (MMPs). G. mangostana
could be a promising therapeutic strategy to treat cancer in the future.
Role of P34S, G169R, R296C, and S486T Substitutions in Ligand Access
and Catalysis for Cytochrome P450 2D6 Allelic Variants CYP2D6*14A
and CYP2D6*14B
Authors: Ong Chin Eng , Dong Amelia Nathania , Ahemad Nafees , Pan Yan , Palanisamy Uma Devi , Yiap Beow Chin
Published: January 2022

Background:

Genetic polymorphism of cytochrome P450 (CYP) contributes to variability
in drug metabolism, clearance, and response. This study aimed to investigate the functional and
molecular basis for altered ligand binding and catalysis in CYP2D6*14A and CYP2D6*14B, two
unique alleles common in the Asian population.

Methods:

CYP proteins expressed in Escherichia coli were studied using the substrate 3-cyano-7-
ethoxycoumarin (CEC) and inhibitor probes (quinidine, fluoxetine, paroxetine, terbinafine) in the
enzyme assay. Computer modelling was additionally used to create three-dimensional structures of
the CYP2D6*14 variants.

Results:

Kinetics data indicated significantly reduced intrinsic clearance in CYP2D6*14 variants,
suggesting that P34S, G169R, R296C, and S486T substitutions worked cooperatively to alter the
conformation of the active site that negatively impacted the deethylase activity of CYP2D6. For
the inhibition studies, IC50 values decreased in quinidine, paroxetine, and terbinafine but increased
in fluoxetine, suggesting a varied ligand-specific susceptibility to inhibition. Molecular docking further
demonstrated the role of P34S and R296C in altering access channel dimensions, thereby affecting
ligand access and binding and subsequently resulting in varied inhibition potencies.

Conclusion:

In summary, the differential selectivity of CYP2D6*14 variants for the ligands (substrate
and inhibitor) was governed by the alteration of the active site and access channel architecture
induced by the natural mutations found in the alleles.
Una nueva especie de Miconia (Melastomataceae) de los bosques altoandinos de Bogotá D.C., Colombia
Authors: Mendoza-Cifuentes Humberto
Published: January 2022

Antecedentes y Objetivos: Miconia, con cerca de 1900 especies, es el género de las angiospermas leñosas más diverso en el Neotrópico y uno de los más grandes del planeta. Durante el desarrollo del proyecto Flora de Bogotá, se encontró una especie no descrita de Miconia, única entre sus congéneres en caracteres de hábito de crecimiento y tipo de tricomas. El objetivo de este artículo es describir esta nueva especie hasta ahora conocida solo de los alrededores del Distrito Capital y compararla con los taxones más similares morfológicamente. Métodos: Se realizó la descripción e ilustración de la nueva especie a partir de colecciones depositadas en el herbario JBB del Jardín Botánico de Bogotá. Las medidas de las partes vegetativas e inflorescencia se realizaron a partir de material seco, mientras que las estructuras florales y frutos fueron medidas a partir de material rehidratado. Se sugiere su estado de conservación con base en los criterios de la IUCN.Resultados clave: Miconia mahechae sp. nov. se caracteriza por su hábito arbustivo-lianescente, entrenudos oblongos, indumento denso-lanoso compuesto de tricomas alargado-irregulares rugosos en entrenudos, peciolos e inflorescencia, hojas ovado a elípticas, 3-nervadas, con la haz lisa y ápice obtuso o agudo, bractéolas inconspicuas, anteras oblongo-obovadas con un poro apical y conectivo basal sin prolongaciones.Conclusiones: La especie nueva se relaciona morfológicamente con Miconia ruizteranii, de la cual se distingue por la forma de las anteras y el indumento de tallos e inflorescencia. Hasta el momento, M. mahechae solo se conoce de los alrededores de la ciudad de Bogotá y los Parques Nacionales Chingaza y Sumapaz, en zonas de bosque altoandino. Con base en los criterios de la IUCN se sugiere su categorización como Vulnerable (VU).
Установление стационарного состояния при наложении интенсивной пластической деформации кручения в двухкомпонентных кристаллах
Authors: Заворотнев Ю.Д. , Метлов Л.С. , Томашевская Е.Ю.
Published: January 2022

The propagation of a switching wave (kink) in two-component crystals during plastic torsion strain has been considered. The phenomenological Landau theory with consideration of Lifshitz invariants was used. A numerical simulation of the shape of the kink that occurs under various temperatures has been performed.
Understanding Adoption and Preliminary Effectiveness of a Mobile App for Chronic Pain Management Among US Military Veterans: Pre-Post Mixed Methods Evaluation (Preprint)
Authors: Hogan Timothy P , Etingen Bella , McMahon Nicholas , Bixler Felicia R , Am Linda , Wacks Rachel E , Shimada Stephanie L , Reilly Erin D , Frisbee Kathleen L , Smith Bridget M
Published: January 2022

BACKGROUND

The Veterans Health Administration Pain Coach mobile health app was developed to support veterans with chronic pain.

OBJECTIVE

Our objective was to evaluate early user experiences with the Pain Coach app and preliminary impacts of app use on pain-related outcomes.

METHODS

Following a sequential, explanatory, mixed methods design, we mailed surveys to veterans at 2 time points with an outreach program in between and conducted semistructured interviews with a subsample of survey respondents. We analyzed survey data using descriptive statistics among veterans who completed both surveys and examined differences in key outcomes using paired samples t tests. We analyzed semistructured interview data using thematic analysis.

RESULTS

Of 1507 veterans invited and eligible to complete the baseline survey, we received responses from 393 (26.1%). These veterans received our outreach program; 236 (236/393, 60.1%) completed follow-up surveys. We conducted interviews with 10 app users and 10 nonusers. Among survey respondents, 10.2% (24/236) used Pain Coach, and 58% (14/24) reported it was easy to use, though interviews identified various app usability issues. Veterans who used Pain Coach reported greater pain self-efficacy (mean 23.1 vs mean 16.6; P=.01) and lower pain interference (mean 34.6 vs mean 31.8; P=.03) after (vs before) use. The most frequent reason veterans reported for not using the app was that their health care team had not discussed it with them (96/212, 45.3%).

CONCLUSIONS

Our findings suggest that future efforts to increase adoption of Pain Coach and other mobile apps among veterans should include health care team endorsement. Our findings regarding the impact of Pain Coach use on outcomes warrant further study.
Effectiveness and feasibility of real-time telerehabilitation for elderly people with musculoskeletal conditions: a systematic review (Preprint)
Authors: Jirasakulsuk Nathaphon , Saengpromma Pattaridaporn , Khruakhorn Santhanee
Published: January 2022

BACKGROUND

Effectiveness of real-time telerehabilitation (RTTR) were evaluated in this systematic review on physical performance, adherence, and cost-effectiveness among elderly people with musculoskeletal condition.

OBJECTIVE

A systematic electronic literature search was conducted in Cochrane, PubMed/MEDLINE and PEDro according to PRISMA guidelines.

METHODS

Systematic review and meta-analysis following PRISMA guidelines. Randomized controlled trials (RCTs) were conducted in the area that involved elderly people with musculoskeletal conditions and any physical performance indexes were included. video conference and phone call were kind of RTTR was defined as a specific remote rehabilitation intervention to allowing healthcare professional/patient interaction. Information regarding the effect and feasibility (intervention completion rate) of RTTR was extracted from eligible articles. This study is registered on PROSPERO, number CRD42021287289

RESULTS

Cochrane risk-of-bias tool was used for revised randomized trials to assess methodological quality of the included articles. Eventually, seven studies were included as eligible articles. The overall risk of bias judgment was assessed as “High” in one studies. All studies were conducted in either South Korea, Canada, Italy, the USA, or Australia, and heterogeneity in terms of participants’ health condition and intervention regimen was observed across the studies. Our narrative-based analysis were reported across the seven studies showed that compared with conventional rehabilitation, either equal or better effects on physical performance.
The intervention completion rates were 87%± 9 on average (range 67–97%).

CONCLUSIONS

Although our studies were limited relevant information with heterogeneity make obtain we could not conclusive evidence, our findings suggest that RTTR can be a strategy for rehabilitation service delivery with acceptable feasibility comparable to conventional rehabilitation for elderly people with musculoskeletal.

CLINICALTRIAL

the PROSPERO registration number CRD42021287289; https://www.crd.york.ac.uk/prospero/
Machine Learning–Based Detection System for ascites in patients with liver cirrhosis Using Laboratory and Clinical Data: Design and Implementation Study (Preprint)
Authors: Hatami Behzad , Asadi Farkhondeh , Bayani Azadeh , Zali Mohammad Reza , Kavousi Kaveh
Published: January 2022

BACKGROUND

Liver disease is one of the leading causes of death worldwide. Chronic liver disease may lead to cirrhosis of the liver in which the main complications of cirrhosis include ascites. All patients, even in cases of suspected cirrhosis, need to be examined for the causes of ascites. Patients with cirrhosis and ascites often go to transplant centers for evaluation of liver transplants and, therefore, there is a need for accurate prognostic models for the diagnosis of ascites, especially in patients with cirrhosis and ascites.

OBJECTIVE

The aim of the study was to implement a non-invasive model to predict ascites grades among patients with cirrhosis.

METHODS

In the present study, we used modern machine learning (ML) methods to develop a scoring system solely based on routine laboratory and clinical data to help physicians accurately diagnose and predict different degrees of ascites. We used ANACONDA3–5.2.0 64 bit, free and open-source platform distribution of Python programming language with numerous modules, packages, and rich libraries that provide various methods for classification problems. Through the 10-fold cross validation, we employed three common learning models on our dataset, k-nearest neighbors (KNN), Support Vector Machine (SVM), and neural network classification algorithms.

RESULTS

According to the data received from the research institute, three types of data analysis have been performed. The algorithms used to predict ascites were KNN, cross-validation (CV), and Multilayer Perceptron Neural Networks (MLPNN), which achieved an average accuracy of 94%, 91, and 90%, respectively. Also in the average accuracy of the algorithms, KNN had the highest accuracy of 94%.

CONCLUSIONS

We applied well-known ML approaches to predict ascites that the findings showed a strong performance in comparison with the classical statistical approaches. This ML-based approach can help to avoid unnecessary risks and costs for patients with acute stages of the disease.
A Review of Clinical Studies for Chinese Medicine Treatment of Post-concussion Syndrome Using the CNKI Database
Authors: Park Mi-so , Ju Ah-ra , Choi Yo-sup , Baek Hye-kyung , Hwang Bo-kyung , Shin Dong-guk , Jang Seung-won
Published: January 2022

Objectives: The aim of this study was to investigate the latest clinical studies on Korean medicine treatment of post-concussion syndrome (PCS) in the Chinese National Knowledge Infrastructure Database (CNKI).Methods: We searched the last 10 years of clinical studies discussing Oriental medicine-based treatments for PCS in the CNKI database. The search focused on the authors, publication year, type of study, purpose of the study, method and duration of treatment, evaluation criteria, and results of each article.Results: Of the 22 selected studies, 1 was a non-randomized controlled trial (nRCT), 2 were case series, and 19 were randomized controlled trials (RCTs). Treatments included oral herbal medicine in 16 studies, oriental medicine through external use in 2 studies, acupuncture in 3 studies, and traditional Chinese medicine injection in 2 studies. The most frequently used herb was Cnidii Rhizoma (川芎). All 22 studies confirmed the efficacy of Oriental medicine treatments.Conclusion: More varied and scientifically designed clinical studies are required to develop treatments for PCS. The results of this study could be used as basic data for further PCS studies.
Filmografía Actualizada para Visualizar las Etapas y las Problemáticas del Proceso de Jubilación
Authors: Aguilera-Velásco María De los Ángeles , Acosta-Fernández Martín , Ordóñez-Hernández Cecilia Andrea
Published: January 2022

Introducción: en 2017 se publicó la filmografía “Mirar y reflexionar la jubilación” para ejemplificar el proceso de jubilación. Contiene 57 películas, clasificadas, con base en la teoría de continuidad, en siete etapas (prejubilación, luna de miel, descanso, desencanto, reorientación, rutina y final) y tres problemáticas (resistencia a jubilarse, jubilación forzada y falta de seguridad social para jubilarse). Tiene el propósito de propiciar la reflexión sobre la jubilación, pero requiere renovación para incluir más cantidad de filmes que mejoren en cantidad y calidad la ejemplificación. Objetivo: actualizar y enriquecer la filmografía de 2017. Materiales y métodos: estudio documental de recopilación y actualización de filmes. La búsqueda fue electrónica y física. Se incluyeron todas las películas, en idioma español, o en otro idioma con subtítulos en español, con argumentos, títulos, sinopsis y críticas relacionadas con la jubilación. El análisis comprendió la selección, captura, categorización y recategorización de los filmes. Resultados: se seleccionaron 115 filmes, sumados a los 57 anteriores, conforman una nueva filmografía de 172 películas, con producciones de 24 países, que incluyen dramas, comedias, documentales, romances, animaciones, aventuras, acción e intriga, en su mayoría protagonizada por hombres. La película más antigua es de 1924 y la más reciente de 2019. Conclusiones: se logró ampliar en 301.75 % la cantidad de filmes. En cuanto a la calidad se logró ilustrar abundante y profundamente el proceso y los problemas de la jubilación. La nueva filmografía es material didáctico útil, adecuado y suficiente para futuras intervenciones de sensibilización y preparación para la jubilación.
COPE Flowcharts and infographics – Peer review manipulation suspected after publication
Authors: Editorial Article
Published: January 2022

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Implante e provisionalização imediatos em área estética – relato de caso
Authors: Brito Fabiano Capato De , Brito Moriza , Resck Thiago Souza , Zimmermann Luis Gustavo , Almeida Pollyany Policarpo de , Arikawa Koji
Published: January 2022

The smile is striking on people’s faces and a large part of the population craves the presence of all teeth, an enviable aesthetic, and a healthy dentition. Regardless of social class, several factors can contribute to the loss of dental elements, such as irreversible failures of endodontic treatments, periodontal diseases, advanced cavities, trauma, and root fractures. With the great evolution of Implantology, the implant appeared with immediate provisionalization, contributing to the loss of dental elements in aesthetic areas. This study aimed to report a clinical case of immediate implant installation and provisionalization after element 11 extraction and filling the gap with biomaterial. Such procedures are fundamental for maintaining horizontal and vertical dimensions in order to reestablish aesthetics and function. After imaging examinations, minimally traumatic extraction of the dental element was continued, installation of the implant and preparation of temporary restoration, conditioning of the gingival profile and, subsequently, molding to deliver the final crown in E.max ceramic. A clinical approach allows patient satisfaction with immediate aesthetics, preservation of the gingival profile, and reduced working time.
ANÓNIMO, «Traducción en prosa de El caballero Orfeo»
Authors: Alonso Navarro José Antonio
Published: January 2022

Resumen
Criteria for choosing the method of inter-hospital transportation of patients with severe trauma
Authors: Kasimov R. R. , Makhnovskiy A. I. , Zavrazhnov A. A. , Samokhvalov I. M. , Miroshnichenko A. G. , Derkach M. A.
Published: January 2022

Objective: substantiate the criteria for choosing a method for inter-hospital transportation of patients with severe trauma for the territorial system of medical support for the troops of the Western Military District.

Materials and methods. We studied 121 cases of inter-hospital transportation of patients with severe trauma in the territorial system of medical support for the troops of the Western Military District for the period 2015–2020. The time of inter-hospital transportation of patients by an ambulance car of class C and by helicopter was studied at various distances between medical organizations: up to 70 km, from 70 to 200 km, more than 200 km.

Results and discussion. At distances between medical organizations of more than 200 km, the average time of medical aviation evacuation of patients with severe injuries by helicopter was 176±35 minutes, and the average time of medical evacuation of patients in a class C ambulance was 290±43 minutes (p=0,04). When the distance between medical organizations is less than 200 km, the average time of medical aviation evacuation of patients with severe trauma by helicopter was 126±43 minutes, and the average time of medical evacuation of patients in a class C ambulance was 137±37 minutes (p=0,85).

Conclusions. The main factor in choosing a method for carrying out inter-hospital transportation of patients with severe trauma in the territorial system of medical support for the troops of the Western Military District is the distance between medical organizations. It is advisable to plan medical aviation evacuation of patients with severe trauma by helicopter when the distance between medical organizations is more than 200 km.
Trayectorias escolares y de inserción profesional de jóvenes marroquíes y rumanos en España
Authors: Laíz Moreira Sofía , Gutiérrez Sánchez José David
Published: January 2022

El presente artículo tiene por objetivo presentar las trayectorias educativas y de inserción profesional de dos colectivos de jóvenes migrantes y en dos contextos específicos del estado español: el caso rumano en la Comunidad de Madrid y el caso marroquí en la Comunidad gallega. El análisis de las trayectorias escolares y profesionales se ha realizado en base a dos estudios llevados a cabo en cada comunidad autónoma en los últimos diez años, siguiendo una metodología fundamentalmente cualitativa. Los sujetos de estudio han tenido en cuenta dos perfiles de joven migrante: los jóvenes inmigrados junto a sus familias y aquellos inmigrados de forma autónoma, separados de sus tutores legales. Un abordaje complejo ha guiado nuestro análisis dando forma a una presentación de dos situaciones migratorias diferentes, en dos espacios sociales diversos, con diferentes poblaciones de estudio. Los resultados han mostrado unas trayectorias truncadas por la situación de desempleo juvenil en España a momentos del estudio con una alentadora potencialidad hacia la agencia social en las niñas marroquíes que superaron con creces los niveles formativos alcanzados por sus padres, si bien no materializados en los puestos de trabajos encontrados hasta el momento. En el caso de los jóvenes rumanos, su permanencia en asentamientos chabolistas explica  la imposibilidad de acceso a los servicios públicos, compartiendo una fuerte dependencia respecto de la eficacia de las medidas de asistencia social con los jóvenes tutelados.  Ambos casos de estudio revelan el impacto determinante del contexto social y del alcance de la estructura institucional en momentos de crisis.
Giant cell arteritis with simultaneous onset of multiple intracranial vascular occlusions: A case report
Authors: Shigeyasu Masashi , Sasaki Natsuhi , Nishino Shogo , Sakai Nobuyuki
Published: January 2022

Background:

Giant cell arteritis (GCA) causes severe stenosis or occlusion of the arteries but rarely affects the intracranial arteries. We report a rare case of GCA along with autopsy results.

Case Description:

A 69-year-old man developed gait disturbance due to vertebral artery (VA) occlusion. As is common in atherothrombotic stroke, dual antiplatelet therapy was administered. The patient’s symptoms improved temporarily. However, his symptoms relapsed and his consciousness was acutely disturbed. Digital subtraction angiography revealed an appearance of stenosis of the internal carotid artery (ICA) C2 portion on the right side and decreased retrograde basilar artery (BA) blood flow through the right posterior communicating artery. Balloon angioplasty was performed, and BA blood flow increased. GCA was suspected, and a definitive diagnosis was made based on temporal artery biopsy findings. Steroid therapy was initiated but failed to control disease progression, and the patient died. The autopsy findings revealed GCA in the bilateral ICAs and VAs, and no signs of GCA were found in other intracranial arteries, despite occlusion on magnetic resonance angiography.

Conclusion:

GCA of the intracranial blood vessels is rare and might be more likely to occur in the ICAs and VAs than in other intracranial blood vessels. GCA of the intracranial blood vessels has a poor prognosis, and as such, if rapid changes are observed in the ICAs or VAs, GCA should be considered a part of the differential diagnosis and immediate treatment should be administered.
Pengembangan Teknologi Produksi Tanaman Berkelanjutan
Authors: Yahya Sudirman
Published: January 2022

Teknologi produksi tanaman berkelanjutan haruslah yang mampu: (1) meningkatkan daya adaptasi tanaman terhadap cekaman kekeringan dan ketersediaan hara yang rendah, dan genangan, (2) membenahi sifat-sifat tanah yang menjadi faktor-faktor pembatas tersebut, yakni dengan memperbaiki kemampuan tanah menahan air dan kapasitas tukar kation, serta meningkatkan ketersediaan hara bagi tanaman, dan (3) mengefisienkan penggunaan input yang berbahan baku "non renewable resources" sebagai energi budi daya. Beberapa prioritas penelitian perlu dikemukakan sebagai upaya mempersiapkan teknologi budi daya agar tanaman mampu beradaptasi terhadap cekaman lingkungan tersebut.

Kajian respon fisiologi tanaman terhadap cekaman dapat diungkap dengan melibatkan beberapa genotipe tanaman yang mempunyai kemampuan berbeda dalam adaptasi terhadap cekaman lingkungan. Pada kajian tersebut biasanya dapat diperoleh karakter morfologi dan fisiologi yang menjadi pembeda tingkat toleransi atau kemampuan adaptasi, sekaligus mekanismenya. Karakter-karakter tersebut selain dapat digunakan sebagai karakter seleksi genotipe yang kita inginkan, juga sangat penting dalam pengembangan teknologi produksi yang dapat memperbaiki atau mengurangi pengaruh cekaman lingkungan tersebut.

Pengembangan teknologi produksi dapat dilakukan dengan pemanfaatan sumber daya alam mikroorganisme tanah melalui perbaikan lingkungan abiotik, interaksi faktor lingkungan abiotik dan biotik. Keramahan sumber daya alam berupa fenomena perbedaan tingkat toleransi terhadap cekaman dan keberagaman sumber daya tumbuhan dapat pula dimanfaatkan bagi pengembangan teknologi produksi. Femanfaatan keramahan sumber daya alam perlu pula mempertimbangkan aspek efisiensi melalui pengembangan teknologi optimasi penggunaannya.
Analisis Pengadaan Input Produksi dan Subsistem Usahatani Padi Sawah di Desa Saik Kecamatan Kuantan Mudik Kabupaten Kuantan Singingi
Authors: Darus Darus
Published: January 2022

Ketersediaan bahan pangan yang dapat untuk mencukupi kebutuhan seluruh penduduk di suatu daerah  menjadi perhatian Pemerintah, karena ketahanan pangan dapat menjaga stabilitas pada  suatu daerah tersebut. Kabupaten Kuantan Singingi yang mempunyai potensi pertanian yang  besar untuk dikembangkan, hal ini di dukung oleh ketersediaan lahan yang luas serta sumber daya manusia yang mayoritas bergerak di bidang pertanian. Sehingga wilayah ini dijadikan sebagai salah satu dari sembilan kabupaten  lumbung padi dalam Program Operasi Pangan Riau Makmur. Desa Saik merupakan Desa dalam wilayah otonomi Kecamatan Kuantan Mudik Kabupaten Kuantan Singingi. Sebagian besar masyarakatnya beraktivitas dalam bidang tanaman pangan  padi sejak tahun 1987, namun demikian produktivitas padi di daerah tersebut masih rendah dibuktikan belum berhasilnya Kecamatan Kuantan Mudik  Berswaswmbada Pangan. Penelitian ini bertujuan untuk mengetahui bagaimana pengadaan sarana produksi dan keragaan usahatani padi sawah di Desa Saik Kecamatan Kuantan Mudik Kabupaten Kuantan Singingi. Hasil penelitian menunjukkan bahwa sarana produksi usahatani padi di Desa Saik tersedia sesuai dengan kebutuan petani, yang ditunjukkan dengan perolehan rerata skor 6 enam tepat > 75 yaitu 81,04. Pada subsistem usahatani padi desa saik diketahui hasil produksi petani berupa beras dengan rata-rata jumlah produksi 4,033.65 kg/ha/musim tanam, petani memperoleh pendapatan kotor sebesar Rp 39,933,103.57/ha/ musim tanam, pendapatan bersih sebesar Rp 10,642,137.69 /ha/ musim tanam, dan rata-rata jumlah pendapatan keluarga yang diperoleh petani dari hasil usahatani padi sawah pada penelitian ini adalah Rp 25,126,273.10 /ha/ musim tanam. Melalui analisa pembiayaan dan analisis efisiensi diperoleh nilai RCR 1,36, yang menunjukkan bahwa usahatani padi sawah di Desa Saik layak untuk dikembangkan,  diiringi usaha untuk meningkatkan efisiensi penggunaan saprodi dan tenaga kerja, sehingga dapat menekan biaya produksi dengan tetap mengupayakan produktifitas hasil yang tinggi.
Pelatihan Aplikasi Pembuatan Slip Upah Karyawan UMKM Desa Cingcin Soreang Kabupaten Bandung
Authors: Muttaqin Muchammad Zaenal , Rosalina Resmi , Ridwan Rahmina
Published: January 2022

Usaha Kecil Mikro dan Menengah (UMKM) adalah salah satu tulang punggung perekonomian masyarakat di daerah Soreang, Kabupaten Bandung. Daerah ini menjadi salah satu sentra konveksi terbesar di Kabupaten Bandung. Salah satu produk yang dikenal adalah kerajinan pembuatan tas, yang dihasilkan oleh para pelaku usaha UMKM di Desa Cingcin, Kecamatan Soreang, Kabupaten Bandung. UMKM pengrajin tas di wilayah tersebut masih menggunakan sistem dan teknologi sederhana dalam menjalankan usahanya termasuk pada produksi, administrasi, marketing, pencatatan keuangan dan penggajian. Tujuan dari kegiatan pengabdian ini adalah memberikan dan mengenalkan cara pembuatan slip upah untuk membantu penyusunan dan transparansi gaji/upah untuk para karyawan dalam UMKM tersebut. Pengabdian dilaksanakan secara online menggunakan media Zoom Meeting berupa presentasi dan praktek (tutorial) pembuatan slip upah, presentasi menggunakan aplikasi Microsoft Office Powerpoint dan Microsoft Office Excell. Peserta kegiatan pengabdian adalah perwakilan pelaku usaha UMKM di Desa Cingcin dan sesama peserta Pengabdian Kepada Masyarakat (PKM) ini. Pelaksanaan pengabdian mendapatkan antusiasme dari para peserta karena sesuai dengan kondisi pelaku usaha dan dapat segera diaplikasikan dengan mudah dan murah.
PELATIHAN PENGELOLAAN KEUANGAN DESA DI KECAMATAN SEBERIDA KABUPATEN INDRAGIRI HULU
Authors: Abrar Abrar , Saputra Dian , Yusnita Raja , Agya Lintang
Published: January 2022

Pada tahun 2019 Provinsi Riau mendapatakan alokasi dana desa bersumber dari APBN sebesar Rp. 1.436.685.874 yang diterima oleh 1.591 desa dari 10 Kabupaten. Namun, berdasarkan laporan realisasi serapan anggaran pemerintah daerah/desa masih di kisaran 75%-85%. Realisasi serapan anggaran yang belum optimal dapat menggambarkan tingkat pertumbuhan ekonomi desa yang lambat. Desa-desa ini memiliki potensi yang sangat besar jika tata kelola keuangan desanya dilakukan secara optimal. Pengabdian ini akan dilakukan untuk membantu pemerintah desa yakni perangkat desa dalam mengelola keuangan desa secara tepat guna dan mencapai serapan anggaran yang optimal. Metode pelaksanaan kegiatan pengabdian masyarakat yaitu dalam bentuk Pelatihan untuk menyampaikan materi serta diskusi dengan perangkat desa yang ada di Kecamatan Siberida Kabupaten Indragiri Hulu. Permasalahan sering tejadi dikarenakan pemahaman yang kurang dari perangkat desa tentang proses perencanaan, penatusahaan, pelaporan dan pertanggung jawaban. Dalam proses perencanaan desa masih mengacu pada anggaran sebelumnya. Sedangkan Ketika penatausahaan dari realisasi anggaran desa masih belum mengetahui mengenai administrasi apa saja yang dibutuhkan. Pelaporan dan pertanggungjawaban dari dana desa masih belum sesuai dengan standar yang telah ditetapkan oleh pemerintah.
Sosialisasi Olahraga Petanque Pada Siswa Smp Negeri 2 Tambang Kecamatan Tambang Kabupaten Kampar
Authors: Yulianti Mimi , Apriani Leni , Amelia Sri , Saifullah Saifullah
Published: January 2022

Tujuan dari kegiatan ini adalah untuk memeperkenalkan olahraga Petanque kepada siswa yang ada di SMP Negeri 2 tambang. Pengabdian ini dilakukan di Lapangan SMP Negeri 2 Tambang. Materi yang diberikan dalam pengabdian ini tentang teknik dan peraturan yang digunakan dalam permainan olahraga petanque. Kegiatan sosialisai ini dilaksanakan dengan metode demonstrasi tentang pelaksanaan permaina petanque Dari kegiatan yang dilakukan diharapkan lahirnya atlit-atlit petanque yang profesional yang bisa mengikuti even-even kejuaraan baik itu yang di tingkat daerash maupun di tingkat nasional dan internasional
THE MAJOR ELEMENTAL COMPOSITION OF MIDDLE PALEOCENE SEDIMENTS OF SOUTHERN INDUS BASIN PAKISTAN: IMPLICATION ON PROVENANCE
Authors: Hakro Asghar A.A.D. , Samtio Muhammad Soomar , Mastoi Abdul Shakoor , Rajper Riaz Hussain
Published: January 2022

The current study area is a northeastern part of Karachi arc and located in Lakhi Range and also the Southeastern part of Karachi arc which is Thar Desert. Present study is focused on Bara Formation with specifically source rock study, as it could be understand that from where these detritus were being supplied, either from Indian craton or Asian plate in Middle Paleocene time. These sediments are composed of Sandstone, Shale, Coal, and Siltstone with some traces of fossils. Ninety five samples of Middle Paleocene sediments from three localities (Ranikot, Lakhra and Thar) with five stratigraphic sections have investigated for geochemical elements identification. The studied sediments have been classified as Litharenite, Sublitharenite, arkose, Sub-arkose greywacke, Iron sand, Iron shale. PIA and CIA of studied section of basin had been facing low/low to high weathering conditions in source area. The majority of samples indicate the passive margin tectonic settings. Middle Paleocene sediments of Southern Indus Basin is concluded here as the sediments had been supplied from Indian shield rocks and it can be summarized that the Indian plate was not collided with Asia plate in Middle Paleocene time (61.6-59.2 million years age) at Southern Indus Basin of Pakistan.
CYTOKININ AND GIBBERELLIC ACID ALLEVIATE THE EFFECT OF WATERLOGGING IN MUNGBEAN (VIGNA RADIATA L. WILCZEK)
Authors: Islam M Rafiqul , Hasan Mehfuz , Akter Nurunnaher , Akhtar Shahrina
Published: January 2022

Recently, waterlogging damage of mungbean is most common in many mungbean growing areas of the world. The exogenous application of phytohormones cytokinin (CK) and gibberellic acid (GA) could be an effective way of managing mungbean under waterlogging stress. Therefore, we applied different levels of CK and GA at the onset of waterlogging and ten days after waterlogging, and the results were observed in waterlogged plants as compared to control. The CK and GA application showed much improvement in depressed morpho-physiological and yield-related traits and seed yield. However, the responses varied depending on the types and doses of CK and GA. The plant height and the number of leaves were higher in GA-applied plants than CK-treated plants. The GA responded more in shoot growth, whereas CK in root development under waterlogged situations. The application of CK at 150 mg/L displayed the highest 33.9% yield advantage. It reveals that exogenous CK could be a good management practice in areas prone to waterlogging stress for attaining better yield in mungbean.
FACILE FABRICATION OF COPPER OXIDE NANOPARTICLES FOR ANTIMICROBIAL ACTIVITY
Authors: Haque Md. Ashraful , Hossain Md. Kaium , Molla Md. Ashraful Islam , Sarker Mithun , Chandra Dey Shaikat , Ashaduzzaman Md.
Published: January 2022

Copper Oxide nanoparticles (NPs) have shown great acceptance in the antimicrobial application owing to their low toxicity and high surface to charge ratio. In this study, copper oxide NPs (represented as S-1, S-2 and S-3) were prepared by a simple and cost-effective thermal approach in three different environments. Fabricated NPs were characterized using x-ray diffraction (XRD), scanning electron microscopy (SEM), ultraviolet-visible (UV-Vis) spectroscopy and Fourier transform infrared spectroscopy (FTIR) technique. The XRD patterns revealed that the synthesized S-2 was of pure Cu2O phase while S-3 was composed of monoclinic CuO with a small quantity of Cu2O. More importantly, synthesized copper oxide NPs were used to evaluate the antimicrobial activity against three types of gram-negative bacteria namely Salmonella typhi, SK4 and E. coli (two strains). Although the NPs produced from the S-1 approach did not show encouraging results, the copper oxide NPs from S-2 and S-3 had shown enhanced antimicrobial activity. The successful antimicrobial activity of S-2 and S-3 can be related to the release of Cu+ and Cu2+ ions into the surrounding environment, which is responsible for the breaking of the cell wall membrane and ultimately causes bacterial cell disruption. The synthesized copper oxide NPs via thermal approach will be good candidates for biomedical applications.
INVESTIGATION OF THE EFFECTS OF SALT DUST CAUSED BY DRYING OF URMIA LAKE ON THE SUSTAINABILITY OF URBAN ENVIRONMENTS
Authors: Isazade Vahid , Qasimi Abdul Baser , Kaplan Gordana
Published: January 2022

Due to the gradual drying of parts of Urmia Lake, several centers of salt dust which is created and influence the agriculture, economy, public health and causes migrations within the region of the Urmia Lake. Hence, knowing the temporal and spatial distribution of this phenomenon is very important to quantify these effects. In the present study, using Sentinel-5 and MODIS products for 2020 in the Google Earth system, have shown despite month-to-month fluctuations, has an increasing trend and the incremental changes of fine dust are more considerable in May and June and their dispersal are greater in the northern and northwestern cities in the basin of the Urmia Lake. The distribution of fine dust in the cities of Tabriz, Shabestar, Urmia, Mahabad, Khoy, Salmas, and Tabak, shows heavy concentrations of the dusts, and exhibits destructive impacts on the economy (60.80%) in December and also has adverse effects on the health index. And most of the referrals of people suffering from diseases caused by fine dust in December is (47.50%). The two indicators of agriculture and migration are closely related and the most effects of salt dust for these two indicators showed (15%) in November and (40.51%) in July, respectively. According to the results, it can be said that these dust particles have the greatest impact on the indices (migration, economy, agriculture, and health) of urban regions of the basin of Urmia Lake from 2019 to 2020. The results of this study can directly contribute to the decision-making process by the local authorities to understand the environmental problems across urban and rural areas of Urmia lakes which is at considerable risk.
La novela histórica como herramienta interdisciplinar en los Estudios Generales
Authors: Caba Liriano Genarina
Published: January 2022

Por su naturaleza, la novela histórica constituye una herramienta interdisciplinar, puesto que en ella converge un conjunto de saberes que tocan de cerca distintas áreas del conocimiento y como tal, juega un papel importantísimo en los Estudios Generales. Esta propuesta se circunscribe específicamente en el ámbito de los estudios Generales tomando en cuenta que desde ellos se promueve “la inter y la transdisciplinariedad”. El objetivo que se persigue a través de este estudio es promover la novela histórica como herramienta interdisciplinar para la articulación de diferentes áreas del conocimiento. El carácter expositivo y argumentativo de este trabajo parte de la investigación, lectura, análisis y consulta de diferentes fuentes bibliográficas que corroboran el valor educativo de la literatura como escenario del que forma parte la novela histórica, así como de los beneficios específicos que ofrece trabajar con este género,  por lo que este ensayo se apoya en la ejemplificación y explicitación de los saberes implícitos en la novela histórica a partir de una en específico: El reino de este mundo de Alejo Carpentier. Para valorar el impacto de haber trabajado esta novela en el aula, se tomó en cuenta la implementación de actividades en las que se articulan todos los saberes implícitos en ella y un conjunto de instrumentos para la sistematización del progreso de los estudiantes en relación con las aspiraciones de un enfoque interdisciplinar. Dentro de los instrumentos de evaluación, se privilegiaron las rúbricas, escalas estimativas y listas de cotejo.  En síntesis, este artículo permitirá acercarnos a la novela histórica y a la literatura desde una perspectiva diferente: recursos a través de los que se puede articular conocimientos desde las distintas áreas convergentes en ellas.
Satisfaction with Inclusive Education Services and its Relationship with Father and Mother Involvement
Authors: Setyarini Annas Dwi , Putri Yunita Hardian , Tyas Fatma Putri Sekaring , Alfiasari
Published: January 2022

Parental involvement in education is essential, especially for children with special needs and the existence of inclusive schools supports children's education fairly so that inclusive education services need to prioritize services to achieve parental satisfaction. The purpose of this study was to analyze parental satisfaction with inclusive education services and their relationship to parental involvement. This research was conducted in one of the inclusive schools in East Jakarta. Samples in this study are mothers and fathers from intact families with children with special needs who attend inclusive schools with purposive sampling technique with as many as 30 married couples. The results show a significant positive relationship between the variables of mother's satisfaction with father's satisfaction and father's engagement with father's satisfaction. Moreover, mother’s engagement was significantly related to mother’s education, while mother’s satisfaction positively correlated with mother’s age. A significant negative relationship was found between mother's satisfaction and father's education; father's engagement with child's age and length of getting inclusive services. The effect test found that the father's satisfaction was significantly affected by father's involvement and mother's satisfaction, while mother’s satisfaction was significantly affected by mother’s age and father's satisfaction. Inclusive schools need to provide optimal services and involve parents in schools to feel satisfied.
Determinants of The Expenditure of Tourist Demand in Coastal Destinations
Authors: TANANA Ariadna , CARUSO María Joselina , RODRİGUEZ Cecilia Alejandra
Published: January 2022

The aim of this work is to analyze the determinants of tourist expenditure in Monte Hermoso, a destination located in the southwest of the province of Buenos Aires, Argentina. Tourist surveys were administered during the austral summer (January-February) and considered as primary information. Socioeconomic and trip-related variables were selected to explain the determinants of the average total expenditure of tourists in this destination. The Ordinary Least Squares (OLS) method was applied. From the results obtained, it was determined that the level of income, origin, group size, and type of accommodation are the regressors that best demonstrate the spending behavior of the destination's domestic demand. Therefore, it is possible to identify the most attractive demand segments that contribute to improving competitiveness and increasing the rate of return of the destination.
Hall and Joule's heating Influences on Peristaltic Transport of Bingham plastic Fluid with Variable Viscosity in an Inclined Tapered Asymmetric Channel
Authors: Yousif Hassen Rasha , A. Ali Hayat
Published: January 2022

This paper presents an investigation of peristaltic flow of Bingham plastic fluid in an inclined tapered asymmetric channel with variable viscosity. Taken into consideration Hall current, velocity, thermal slip conditions, Energy equation is modeled by taking Joule heating effect into consideration and by holding assumption of long wavelength and low Reynolds number approximation these equations simplified into couple of non-linear ordinary differential equations that solved using perturbation technique. Graphical analysis has been involved for various flow parameters emerging in the problem. We observed two opposite behaviors for Hall parameter and Hartman number on velocity axial and temperature curves.
Some Games in áº›- PRE- g- separation axioms
Authors: B. Esmaeel R. , Jassam Ahmed A.
Published: January 2022

The primary purpose of this subject is to define new games in ideal spaces via set. The relationships between games that provided and the winning and losing strategy for any player were elucidated.