bluuebunny/crossref_metadata_2025 huggingface dataset:
COVID-associated rhino-orbito-cerebral mucormycosis
Authors: Megharaj Priyanka C. , Patil Vikram M. , Reddy Santosh
Published: September 2022

INTRODUCTION:

Rhino-orbito-cerebral mucormycosis (ROCM), a life-threatening, acute fungal infection of the nasal cavities and paranasal sinuses, once considered a rare and lethal complication in immunocompromised patients, is now having a massive increase in ROCM incidence in India associated with COVID-19, i.e., COVID-associated mucormycosis with more than 15,000 cases as of May 2021. Early imaging by computed tomography (CT) and magnetic resonance imaging (MRI) is not only helpful in assessing the extent of involvement of this lethal disease but also helps in early diagnosis leading to prompt and aggressive treatment. The present study is aimed at determining and comparing the imaging findings on CT and MRI in ROCM patients, for early diagnosis in suspected cases of ROCM.

MATERIALS AND METHODS:

The present study is a comparative study of CT and MRI done on 11 patients suspected of ROCM, for 2 months from May to June 2021.

RESULTS:

Among 11 patients in the study group, ranging from 29 to 65 years of age, 45.4% belonged in 41–60 years of age group, with female predominance. 90.90% cases (10 patients) had maxillary sinus involvement among which 7 cases were diagnosed with ROCM, followed by 63.60% cases (7 patients) had ethmoidal sinus involvement among which 6 cases were diagnosed with ROCM. The involvement of retromaxillary space, pterygopalatine fossa space and masticator space, and cellulitis in premaxillary and preseptal spaces were findings seen only in diagnosed cases of ROCM. Erosions of bones were seen in ROCM cases, 27.20% cases (3 patients) had erosions of walls of maxillary sinus and lamina papyracea each. Orbital involvement in the form of intraconal space and extraocular muscles involvement was seen in 27.20% cases (3 patients) each. Optic nerve involvement was seen in 18.10% cases (2 patients) followed by extraconal space involvement in 9.01% cases (1 patient). Taking KOH staining and/or histopathology (HPR) as standard of reference, CT has a Sensitivity (Sn) of 71.40%, Specificity (Sp) of 100%, Positive predictive value (PPV) of 100%, Negative Predictive Value (NPV) of 66%, and Diagnostic accuracy (DA) of 81% as compared to MRI which has a Sn of 85.7%, Sp of 100%, PPV of 100%, NPV of 80%, and DA of 90.9%.

CONCLUSIOIN:

CT and MRI play a complementary role in diagnosis of ROCM, as CT is better in detecting bone erosions, whereas MRI is better in detecting soft tissue, orbital and central nervous system involvement. In the acute state of emergency as in the current pandemic with rising cases of ROCM and acute shortage of amphotericin-B, MRI is the single best modality for accurate detection of ROC, helping clinicians in the judicious use of Amphotericin-B.
Decreasing fertility trend in Sikkim
Authors: Chauhan Bal Krishna , Bhutia Dechenla Tshering
Published: September 2022

AIMS:

Factors determining low fertility in Sikkim, India.

PRIMARY OBJECTIVE:

The primary objective was to determine the factors for the low fertility in Sikkim.

SECONDARY OBJECTIVE:

The secondary objective was to find out the prevalence of contraceptive use and its types in Sikkim.

SUBJECTS AND METHODS: Study Setting:

The study was conducted in the State of Sikkim.

Study Period:

The study period was 1 year (from February 2020 to January 2021).

Study Population:

The study population was female counterpart of the eligible couple. An eligible couple refers to a currently couple wherein the wife is in the reproductive age, which is between 15 and 49 years.

Inclusion Criteria:

Inclusion criteria were female counterparts of the eligible couple who consent to participate in the study.

Exclusion Criteria:

Exclusion criteria were male counterparts of the eligible couple.

Study Tool:

Structured pre-tested questionnaire was used to take the interview of the participants.

Statistical Analysis Used:

SPSS version 25 was used for statistical analysis.

RESULTS:

It was seen that having two or more children was higher for mothers who had married below 30 years than after 30 years with 14.9% and 6.9%, respectively (P = 0.03) and maximum mothers belonged to 30–34 years age group. The perception of the family size of the mother was that three-fourth (76.1%) responded to having two children, whereas 10.7% perceived one child to be sufficient and 13.2% mentioned having three or more. The overall contraceptive prevalence rate was found to be 73.8%.

CONCLUSIONS:

Causes for low fertility rate are multifactorial; some important ones are the perception and practice of concise and small family size and high contraceptive prevalence rate.
Difficult airway management in a case of bilateral congenital torticollis
Authors: Priyanka C. , Shanu S. , Brindha R.
Published: September 2022

Anatomical disorders of the head and neck pose a serious challenge to an anesthesiologist in terms of difficult intubation. Securing airway requires a detailed preanesthesia evaluation to assess any issues associated with the disease, especially concerning the airway. This is the case of a 46-year-old male with congenital bilateral torticollis posted for elective functional endoscopic sinus surgery. A detailed preanesthetic checkup was done and was anticipated a difficult airway situation, hence planned for an awake intubation. We performed a successful awake fiber-optic intubation. Excessive muscular atrophy and fibrosis characterize congenital bilateral torticollis, resulting in sternocleidomastoid tension and limited cervical motion. During intubation, asymmetry in the face caused a mismatch between the facial and cervical midlines, making sniffing difficult. Successful anesthetic management in a case of congenital bilateral torticollis requires thorough knowledge about the anatomical changes and also the expertise in fiber-optic bronchoscopy.
Effect of expired pharmaceutical dumping on ecological community
Authors: Vishwas Dipanshu Kumar
Published: September 2022

Most people usually throw unused or expired medicines at open landfill sites or isolated locations completely inadvertently due to the consequences and lack of drug disposal facilities. Thus, our field of investigation focuses on whether disposal medicine has any direct effect on various life forms, including humans. This investigation describes how medicinal metabolites develop through wastewater that continuously enters the aquifer and soil environment. Since the discharge of toxic drugs has antibacterial activity, loss of soil fertility, aquatic species have a feminizing effect in males, and bioaccumulation affects inland animals including humans promote global consequences, and thus food affects the chain. Thus, a review of this study might furnish a good conception on the issue of lapsed pharmaceutical wastage and its effect on biological networks. The work concludes with better knowledge about the current conditions of drug wastage around the world, including India, and how biologically active ingredients can have devastating effects on the metabolism of various life forms in the ecological community. This article can also be very useful for understanding, aware and cautioning about the future consequences of drugs by people carelessly in the environment, and turning the brain to the urgent need for a strict and complete proof policy on its safe dumping so that its harmful effects on the environment can be minimized.
Assessment of clinical skill competency of medical postgraduate students – Recommendations for upcoming CBME curriculum for postgraduates
Authors: Rajashree R. , Kottagi Smita , Jambale Triveni , Channashetti Gajanan
Published: September 2022

Direct observation of postgraduate medical trainees with actual patients by clinical faculty has traditionally been a standard tool to assess knowledge and skills in clinical subjects. By assessing and providing feedback to medical trainees performing a medical interview, physical examination, or counselling patients, faculty can facilitate budding physicians to have successful practice of medicine in their future. Despite the advances in clinical skills evaluation, direct observation has been a most popular and time tested method. However, observation of postgraduate medical students by faculty is very subjective and unfortunately often sporadic and non-standardized. Substantial amount of literature identifies several threats to its construct validity as an assessment tool. Although many tried to demonstrate methods to minimize those threats, there are many lacunae that remain inherent to direct observation method. Hence the need of the time is to relook at the observation as an assessment tool, instead of discarding the whole as inappropriate one. The authors initially made an effort to analyse the problems in present settings in India. After an extensive literature search authors advocate few additions and modifications to the existing system. Thus the present study not only highlights the pitfalls in the direct observation method but also suggests solutions for the problem.
Hydrogen gas promotes apoptosis of lung adenocarcinoma A549 cells through X-linked inhibitor of apoptosis and baculoviral inhibitor of apoptosis protein repeat-containing 3
Authors: Zhang Yu , Chen Gang , Yan Zhenfeng , Wang Lifei , Wang Dongchang
Published: September 2022

Objective:

Lung cancer is currently the cancer with the highest incidence and death toll worldwide. Hydrogen gas has been found to affect a variety of diseases; however, the effect of hydrogen gas on patients with lung cancer has not been reported. Therefore, we determined the effect of hydrogen gas on apoptosis of lung adenocarcinoma in vivo and in vitro.

Materials and Methods:

A549 cells in the logarithmic phase were treated with 20%, 40%, or 60% hydrogen gas. Cell apoptosis was evaluated by flow cytometry. The A549 cell suspension was inoculated into 15 nude mice. The mice were randomly divided into control, hydrogenation (inhalation of 60% hydrogen gas), and cisplatin groups (intraperitoneal injection of cisplatin [4 mg/kg]). After 3 weeks, the tumor tissue was removed and measured. We identified differentially expressed genes by transcriptional profiling. The levels of X-linked inhibitor of apoptosis (XIAP), baculoviral inhibitor of apoptosis protein repeat-containing 3 (BIRC3), and BCL2-associated X and apoptosis regulator (BAX) protein expression were detected by Western blotting and immunohistochemistry.

Results:

Compared with the control group, the apoptosis rates in the 20%, 40%, and 60% hydrogen gas groups were significantly increased (P < 0.01). The levels of XIAP and BIRC3 protein expression were clearly decreased in the hydrogen gas group compared to the control group. Moreover, cisplatin and hydrogen gas reduced the tumor volume in nude mice (P < 0.01). Transcriptome sequencing showed that XIAP, BIRC2, BIRC3, BAX, PIK3CD, and ATM were related to apoptosis. Hydrogen gas further decreased the levels of XIAP and BIRC3 expression than in nude mice (P < 0.01).

Conclusion:

Hydrogen gas promoted apoptosis of A549 cells by reducing the expression of XIAP and BIRC3 protein.
Low-grade adenosquamous carcinoma of the breast: A rare case presentation
Authors: Abrari Andleeb , Shehwar Durre , Akhtar Kafil
Published: September 2022

Low-grade adenosquamous carcinoma of the breast is a rare variant of metaplastic mammary carcinoma. It shows indolent behavior contrary to the usual aggressive nature of metaplastic carcinomas and has a good prognosis despite being triple negative. Recurrence rates tend to be high and a consequence of incomplete excision. Although this variant has an infiltrative growth pattern, owing to its bland cytologic features, it is liable to be confused with benign sclerosing adenotic breast lesions. We present here a case of a 55-year-old postmenopausal female, who presented with a painless, mobile, hard, and nontender lump in the lower outer quadrant of the left breast, with normal overlying skin and nipple–areola complex. No associated axillary lymphadenopathy was seen. On mammography, a high-density mass of architectural distortion, characterized as BIRADS category 4C, was found. Core-needle biopsy showed haphazard glands lined by a double layer of epithelium and nests of squamoid cells arranged in an infiltrative fashion within a fibromyxoid stroma. On immunohistochemistry, tumor cells showed a lack of expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 receptor and were positive for CK 5/6 and CK7. There was counterintuitive, but characteristic positivity for myoepithelial markers calponin and CD 10 around the neoplastic nests and stromal cells expressed smooth muscle myosin. Subsequently, the patient underwent a wide local excision with free margins and sentinel lymph nodes were negative for tumor deposits. This patient remains well and free of recurrence well into follow-up.
Stromal microenvironment namely angiogenesis, tumor-infiltrating lymphocytes, and matrix metalloproteinase in invasive breast carcinoma
Authors: Srivastava Gunjan , Pant Leela , Kudesia Madhur , Singh Sompal , Gupta Ruchika
Published: September 2022

Background:

The role of stromal microenvironment in growth, invasiveness, and metastatic potential of breast carcinoma (BC) is being recognized increasingly, both to predict prognosis and as potential therapeutic targets. The present study aimed to evaluate the correlation of angiogenesis, tumor-associated lymphocytes, and stromal CD10 expression with clinicopathologic parameters.

Materials and Methods:

This study included 100 consecutive cases of invasive BC undergoing modified radical mastectomy. Relevant clinical details, pathological grade, lymph nodal status, and clinical stage were noted. Paraffin-embedded sections were subjected to immunohistochemistry for CD34, CD20, CD45RO, and CD10. Microvessel density (MVD), tumor-associated lymphocytes, and stromal CD10 expression were estimated from these sections. Statistical analysis was done using nonparametric tests to correlate the clinic-pathologic features with each of these parameters.

Results:

MVD was found to be significantly higher in Grade III, node-positive cases, and higher stage breast cancers (P < 0.05). The number of T-lymphocytes was higher in node-positive cases, while B-lymphocytes were lower in number in higher grade tumors. CD10 expression showed a significant positive association with tumor grade, nodal status, and stage (P < 0.05 for each).

Conclusion:

This study demonstrates that changes in stromal microenvironment of BC such as MVD, tumor-associated lymphocytes, and stromal CD10 expression correlate with the clinicopathological parameters and hence may be exploited as prognostic markers or therapeutic targets, based on further larger studies.
Morbidities and Health-Seeking Behavior of Elderly Patients Attending Primary Health Care in the Kingdom of Bahrain
Authors: Bahram Samya , AlSayyad Adel Salman , Al Nooh Fatima , Al Farra Wafa , Al Ekri Ali
Published: September 2022

Background:

Understanding the health-seeking behaviors help in increasing the effectiveness and efficiency of the health-care system; however, there is lack of knowledge regarding the health-seeking behavior of the elderly population in the Kingdom of Bahrain.

Objective:

The objective of this study was to identify the morbidity profile and determine the health-seeking behavior of the elderly population.

Methods:

This cross-sectional study included all elderly patients (≥60 years) who attended four primary health-care centers that represent four governorates with the largest catchment area in the Kingdom of Bahrain between June 19 and August 31, 2021. Information concerning their sociodemographic data, morbidity profile and health-seeking behavior were collected through direct interviewing using a structured, predesigned and pretested questionnaire.

Results:

A total of 414 elderly patients were included, with the majority being Bahraini (89.1%) and male (55%). The most prevalent morbidity was hypertension (67.6%), followed by hyperlipidemia (54.7%), diabetes (52.6%), and arthritis (32.1%); arthritis was significantly more common among females than males (P < 0.001). The majority reported the reason for their visit being “repeat prescription” (32.1%). Almost one-third (28.2%) attempted self-management prior to their visit, and almost half (46.7%) reported seeking non-professional medical advice. The majority rated their health as good (39.4%) and moderate (38.2%). Less than one-third (28%) reported having had a health problem for which they did not attend to a health care facility.

Conclusion:

The study highlighted the morbidity profile and the health-seeking behavior among elderly population in Bahrain, which may serve as a point from which further efforts may be directed to improve the services.
Protocolos de tratamiento a la COVID-19: aproximación desde una perspectiva farmacoterapéutica
Authors: Astorga González Beatriz , Dupotey Varela Niurka M.
Published: September 2022

La introducción de los protocolos y guías de actuación clínica en los contextos sanitarios ha jugado un papel esencial en el combate a la COVID-19. Es por ello que el presente trabajo muestra los resultados derivados de una revisión narrativa realizada para describir el diseño e implementación de protocolos para el tratamiento a la COVID-19 en diferentes contextos sanitarios, desde el análisis de criterios farmacoterapéuticos. La metodología de Zillmer de 2018 fue utilizada, estableciéndose criterios para la inclusión de las publicaciones. De acuerdo con este criterio fueron identificadas 48 publicaciones, entre las que se incluyeron publicaciones originales, ensayos clínicos, estudios de revisión, descriptivos y de intervención. Se analizaron las intervenciones farmacológicas realizadas por cinco protocolos correspondientes a la Organización Mundial de la Salud (OMS), Brasil, Estados Unidos, China y Cuba. Las guías de la OMS y Estados Unidos realizaron recomendaciones a favor del uso de corticoesteroides sistémicos y anticuerpos monoclonales y no recomendaron el uso de hidroxicloroquina, lopinavir/ritonavir y remdesivir (solo en el caso de la OMS) basados en los resultados de los ensayos RECOVERY, REMAP-CAP y SOLIDARITY. China y Cuba recomiendan el uso de la cloroquina, lopinavir/ritonavir y los interferones. Cuba recomienda el uso de anticuerpos monoclonales entre los que resaltan nuevos productos que evidencian el avance de su investigación biotecnológica. Por su parte el protocolo de Brasil abarca limitadas recomendaciones entre las que se encuentra evitar el uso de corticoesteroides sistémicos. La generalidad de medicamentos utilizados para el tratamiento de la COVID-19 carecen de evidencia científica suficiente que respalde su uso y actualmente se encuentran en fase de investigación, por lo que los protocolos están sujetos a cambios conforme avanzan dichas investigaciones. Sin embargo, la información científica disponible y basada en la evidencia, ha contribuido a la toma de decisiones farmacoterapéuticas para el enfrentamiento a la pandemia en los países.
Orden y caos en la escena global
Authors: Villasmil Espinoza Jorge J.
Published: September 2022

El propósito del documento es servir de editorial a edición de julio-diciembre, Vol. 02, No. 03 de Multiverso Journal y, simultáneamente, presentar los trabajos que se presentan en este nuevo número. Se reflexiona que el caos y el orden son procesos interconectados que, como indica la didáctica materialista de los contrarios que se complementan, son necesarios para hacer avanzar los procesos históricos y, en algunos casos concretos, llevar a algunas civilizaciones a una fase evolutiva superior de su realidad política, económica y tecnológica. Sin embargo, aunque no hay duda de que algunos actores de poder apuestan al caos para sacar provecho de los innumerables conflictos que aquejan aun hoy a buena parte de las sociedades humanas, quizá emulando a las fuerzas primigenias del universo que por ejemplo hace de una supernova un evento necesarios en la creación de nuevas estrellas, apostar al caos es sumamente peligroso ya que podría iniciar el declive definitivo de la humanidad y, porque no, las destrucción del planeta tierra por efectos de una conflagración nuclear.
La autonomía política del Caribe norcontinental colombiano
Authors: Horta Orozco Jorge Luís
Published: September 2022

Al igual que en buena parte de Latinoamérica la búsqueda de más y mejores espacios de autonomía política y territorial ha sido la respuesta en Colombia al centralismo histórico andino que ha reducido el adelanto de las capacidades multidimensionales de diferentes entidades territoriales que, ayer y hoy, aspiran apalancar su desarrollo regional integral. En consecuencia, el objetivo de este artículo es analizar y discutir la trascendencia y sentido de la construcción de la autonomía política del Caribe norcontinental colombiano, región natural, histórica y política que por derecho propio puede aspirar legítimamente a la autodeterminación de sus comunidades. Metodológicamente se trata de una investigación documental cercana a la hermenéutica dialéctica. Las fuentes interpretadas permiten concluir que la independencia, esto es, la autonomía política radical de una región histórica con una territorialidad determinada e identidad particular en el mundo, que la aleja o la acerca de otras colectividades humanas, no tiene porque que ser un acontecimiento dramático, mucho más cuando la historia mundial en su movimiento dialéctico nos muestra que las formaciones políticas como los Estados, imperios, naciones o incluso civilizaciones, se transforman, cambian o perecen en función de una multiplicidad de factores políticos, económicos, geográficos o climáticos, entre otros.
De la intelectualidad y compromiso político con un estatus civilista
Authors: Lobo Álvaro
Published: September 2022

El presente texto se elaboró como una manifestación consciente de la necesidad de asumir, en lo personal, una postura política frente a la realidad de la cual se es sujeto histórico y observador activo. Por ello es posible, desde la fuerza del conocimiento, la convicción de una madurez intelectual alcanzada y una permanente sensibilidad social, compartir de manera propositiva esta acuciosa reflexión y ejercicio académico personal. El objetivo principal es aproximar la tesis a la comunidad de intelectuales y científicos sociales para experimentar sinergias ideológicas y conceptuales que acarician la utopía de un mundo diferente. Como un abordaje metodológico de fundamentación documental, el ensayo soporta su verificación en los aportes de respetados teóricos y autores de las ciencias sociales, como punto de apoyo para insistir con una propuesta teórica que, en matices varios, ha estado en las voces de personajes de época. En el entendido de caracterizarse el presente trabajo en el marco de una indagación documental, producto de la lectura del acontecer histórico, los resultados están sujetos al escrutinio de la comunidad intelectual, y con suerte someterse a valoración. Finalmente, dada las condiciones de signos apocalípticos que hoy enfrenta la sociedad, la consigna es un mundo más humanizado.
Medidas cautelares sustitutivas a la privación de la libertad en el ordenamiento jurídico venezolano
Authors: Silva Fernando
Published: September 2022

La presente investigación tiene como objetivo analizar el régimen jurídico referente a las medidas cautelares sustitutivas a la privación de la libertad en Venezuela, en atención a sus principios. Se aborda con la estrategia de investigación descriptiva-documental, sustentada en el método analítico. Las fuentes para recolectar la información atienden a tres ámbitos: constitucional, legal y doctrinal. La protección del derecho fundamental a la libertad exige la incorporación reforzada de los preceptos del Derecho Penal a la tarea de cada intérprete de las normas jurídicas. La realidad amerita elevar la protección de los ciudadanos que podrían enfrentar la aplicación de la norma contenida en el Código Orgánico Procesal Penal de manera arbitraria. En consecuencia, se recomienda fomentar una educación orientada al respeto de lo establecido en la norma no solo en aquella previamente mencionada, sino en la diversa normativa, lo cual permite impulsar un ambiente que no relacione el derecho a la libertad con impunidad y que proteja los derechos inherentes al ser humano.
Derecho a la verdad dentro del empoderamiento de víctimas en Colombia
Authors: Vargas Machado Camilo Andrés
Published: September 2022

El objetivo del artículo fue discutir las representaciones del derecho a la verdad como herramienta de empoderamiento de las víctimas del conflicto armado en Colombia. Por lo demás, este documento es producto de una investigación cualitativa, documental de tipo descriptivo, con enfoque hermenéutico. En Colombia a partir del año 2016 el desarrollo del derecho a la verdad, entendido desde la óptica del derecho internacional como medio de empoderamiento de las víctimas del conflicto armado, donde se conceptuó que el Gobiernos Nacional, los Factores Reales de Poder y la Sociedad podrían no estar permitiendo, ni exigiendo, que las víctimas satisfagan su derecho a la verdad, que es tanto conocerla como expresarla. Se concluye que para el ejercicio del derecho a la verdad puede tener un papel muy importante el reconocimiento de experiencias, relatos y narraciones como medio para cultivar la tolerancia que solo se da con el reconocimiento del otro, lo que incluye el empoderamiento a los agentes del Estado como víctimas. Problemática que continua hasta hoy, por lo que se presenta una propuesta de solución viable a través de acuerdos convergentes; con narrativa y reconocimientos de las partes interesadas.
Reflexiones sobre el régimen notarial en el Ecuador
Authors: López Véliz Alcida Liliana , Calle García Jorge Isaac
Published: September 2022

La presente investigación pretende reflexionar sobre el régimen notarial en el Ecuador. Para alcanzar dicho objetivo, el manuscrito está basado en el método analítico siendo una investigación de alcance descriptivo y de tipo documental. Las fuentes principales son la Constitución del Ecuador y un conjunto de doctrina y jurisprudencia acerca del tema seleccionado. Los resultados obtenidos dan cuenta de la importancia que reviste tener certeza en los documentos y declaraciones realizadas, lo cual se obtiene a través de la atribución nacida del imperio estatal y la soberanía correspondiente; en este sentido, el Ecuador como Estado garante de los derechos de las personas acude al otorgamiento de competencias para dar fe pública, concretamente, la tarea les está encomendada a los notarios. De las conclusiones se puede destacar, que en el Ecuador las notarías poseen una descentralización parcial porque tienen trabajadores a su cargo, pero cada una de sus actividades está ceñida a las órdenes y disposiciones emanadas del Consejo de la Judicatura y del ordenamiento jurídico en general.
Plataforma de portal digital creada para registro, estudio, evaluación y promoción de la Diáspora Venezolana
Authors: Benavides Piña Juan Carlos , González Lobeto José Enrique
Published: September 2022

La República Bolivariana de Venezuela presenta una crisis humanitaria compleja señalada por Organismos Internacionales tales como Comisión Interamericana de Derechos Humanos (CIDH) que ha forzado una migración que puede llegar a sobrepasar los niveles de Siria. Esta Diáspora se encuentra ubicada a nivel global y tiene un gran potencial de desarrollo en los países anfitriones y, muy especialmente, en el país de origen. Se requiere crear una plataforma de portal digital para el estudio, evaluación, registro y promoción de este recurso venezolano en su mayor parte calificado y con gran experiencia todo ello a través de la realización de entrevistas y encuestas con personal especializado y capacitado y, asimismo, con un personal de voluntariado en cada ciudad y país del orbe contando para ello establecer una sede en una capital de primer mundo y además una sede en una ciudad importante de un estado en la República Bolivariana de Venezuela con la visión de redireccionar ese gran capital humano a su tierra de origen.
Improving Energy Efficiency in Cloud Computing Data centres Using
Intelligent Mobile Agents
Authors: Charan C S
Published: September 2022

Cloud computing has become a profound name and also a solid bedrock for new emerging technology. Cloud technology fully supports the dynamic provisioning of computing resources as a utility service on a pay-as-you-go approach. Its numerous benefits (such as rapid elasticity, flexibility, network resource pooling) empower small, medium, and large enterprises to use other technologies through the Internet's flexibility. Despite the benefits cloud technology offers, the challenge of the high power consumption rate it incurs as it leverages its promised attributes remains a major concern. Academic research has shown that a typical 500 square meter data centre consumes about 27,048 kilowatts per hour of power per day regardless of whether it is active or not. Over the years, the most dominant energy efficient techniques for managing data centre has been Dynamic voltage frequency scaling and virtual machine consolidation, which has had a significant setback due to its inability to manage systems on overload state. Therefore, a novel paradigm based on an intelligent mobile agent approach has been proposed. This proposed approach is highly intelligent can easily detect underutilised and overloaded components of the data centre due to its unique feature. Agent technique has successfully shown it can prevent and manage overloading issues due to change in workloads and achieve a more efficient load balancing with a low power consumption rate. The mobile agent was embedded into servers and switches to regulate their activities and then shut down underutilised
components. Mobile agent (Java agent) is the first of its kind used in a cloud environment. This research proposal saves a significant amount of energy and improves the entire system performance. In this thesis, the intelligent-based Agent approach is used to address energy efficiency and costaware related problems. Agent approach helps facilitate resource management, allocation of cloud data centre components with a significant reduction in energy usage rate with a more efficient system performance while maintaining a highly reliable system as promised by service providers.
Opportunities and Barriers in ICT Integrated Education: A Critical Analysis
Authors: Mikael L. Chuaungo  , K. Lalnunsiami  , Lokanath Mishra
Published: September 2022

With the growth of digital technologies, there has been an exemplar shift in pedagogy and educational content. The information and communications technology focused training specially helps with the better and effective learning for students and improves their knowledge competencies as well. It also has paved the way for permitting learner-targeted pedagogy in place of traditional teacher- centered pedagogy. This facilitates the learners to work higher and it additionally permits the teachers to adjust
their teaching or content material-delivery alternatives. ICT- supported teaching helps in generating the powerful studying manner via collaborative, evaluative, innovative and integrative getting to know method. This article studies the impact of information and communications technology on the educational quality, the barriers and ways to overcome the presenting challenges. It is revealed that ICT integration is mediational and involves a developing process rather than a completed outcome. Successful technological integration requires collaboration from three parties: teachers, students, and school officials. This critical analysis examines the existing state of affairs, as well as the hurdles to and options for ICT integration in the classroom.
Depression among Women as per Their Marital Status- An Analytical Examination
Authors: Deepthi M  , JV Muruga Lal Jeyan  , Abhinav Kumar
Published: September 2022

Women's perspectives have completely changed over the past few decades. Whereas they once thought of themselves as saleswomen entering the marketing industry and adapting the progressivepath for their livelihood, today's women see themselves as housewives caring for domestically dependent family members, giving birth to their children, and keeping themselves constantly busy. Pt. Jawaharlal Nehru believed that rather than keeping them busy with home economic affairs, they should constantly be actively participating in the social and political life of the country. Depression symptoms appear when we react negatively to life's circumstances repeatedly, intensely, and frequently. Numerous situations that arise in life cause us to experience both positive and negative emotions, such as enthusiasm, irritation, fear, and happiness. Angry, depressed, happy, etc. All age groups and practically all stages of life are affected by depression. Depression symptoms can appear in people of any age, including toddlers and adults. Depending on the personality type, even modest stressors can trigger depressive symptoms. Stress and depression can create symptoms including extreme melancholy, a lack of interest in anything, difficulty getting to sleep or sleeping too much, feelings of powerlessness, and suicidal thoughts. Women have been working for about 100 years now, in fact. One of the most important issues in society is the employment of women. since women became active in society. Therefore, the focus of the current research work is on the dissatisfaction and depression experienced by married and single women.
Factors Influencing Student Academic Performance in Online Credit Recovery
Authors:   University of Nevada, Las Vegas, Nourse Dave
Published: September 2022

Recent estimates show nearly 90% of school districts nationwide offer some form of online credit recovery. Despite its widespread adoption, there is a dearth of research surrounding the suitability of online credit recovery for students. This study examined potential success factors of students enrolled in virtual recovery courses in a school district in the mid-Atlantic region of the United States. Descriptive statistics, chi-square analysis, and binary logistic regression modeling was used for data analysis to account for the influence of student characteristics on credit recovery outcome. Findings revealed that grade-level, IEP status, and middle school End-of-Grade Test results could be linked to achievement in online credit recovery courses. Implications of these findings for educators are discussed
Efforts to Improve Activities and Learning Outcomes of Volleyball Basic Techniques of Lower Passing Using the Drill Method
Authors: Sugito Sugito
Published: September 2022

Research that focuses on teachers' efforts to increase activities and results. This study aims to improve volleyball bottom passing learning through the drill method for fifth graders at SD Negeri 2 Kalangan, Klego District, Boyolali Regency for the 2019/2020 Academic Year. This research is a Classroom Action Research (CAR). which consists of two cycles, each cycle consists of 1 meeting. The subjects of this study were the fifth grade students of SD Negeri 2 Kalangan, Klego District, Boyolali Regency, for the 2019/2020 academic year, with a total of 11 students. The instruments used for data collection in this study were the bottom passing assessment sheet, observation sheet for students and observation sheet for teachers. Groups for 2 cycles can improve student achievement. This can be proven from the results of observing student learning outcomes from 11 students in the initial conditions the number of students who achieved a KKM score of 70 was only 1 student, and in the first cycle increased to 6 students, then in the second cycle, increased to 11 students who achieved a KKM score of 70 even more. So that classical completeness in the class has more than 75% of students who have completed learning
Adding Calcium Influence on Compressive Strength of Mortar with Different Cement Variations
Authors: Yanuar Khairil , Hafizh Ihsani Abdul , Effendi Faryanto , Suhaimi Muhammad , Ruspiansyah Ruspiansyah
Published: September 2022

Mortar is a mixture of binder and sand in a certain ratio, the binder is cement and lime. This test aims to determine the results of the compressive strength of mortar aged 3,7,14, and 28 days on variations of cement and lime mixture. The fine aggregate used in this test is Barito Sand which is included in zone 2. With the composition of the mixture used is 1 pc : 5 ps for cement and sand, the mixture used for cement, lime and sand is 1 pc : 1_4^1kp : 5 ps. From the results of this study with the same mixture proportions, the compressive strength for the variation of cement conch (PCC) = 7.40 MPa, the variation of cement gresik (PPC) = 10.41 MPa, the variation of cement conch with a mixture of lime = 4.54 MPa and strong Press the mortar for the variation of Gresik cement with a mixture of lime = 7.90 MPa. It can be concluded that the compressive strength of mortar for cement conch with a mixture of lime is higher than the variation of cement conch, gresik and conch with a mixture of lime
Faktor Risiko Kanker Serviks Pada Wanita Lanjut Usia Di Rsd Gunung Jati Kota Cirebon
Authors: Lelly Euis
Published: September 2022

Berdasarkan data dari Yayasan Kanker Indonesia (YKI) tahun 2016, Penderita kanker di Indonesia pada tahun 2016 sebesar 17,8 juta jiwa dan tahun 2017 menjadi 21,7 juta jiwa. Setiap tahun tidak kurang dari 15.000 kasus kanker serviks terjadi di Indonesia. Wanita yang terdiagnosa kanker serviks rata-rata berumur >45 tahun keatas atau memasuki fase lanjut usia. Penelitian ini bertujuan untuk mengetahui faktor resiko wanita lanjut usia penderita kanker serviks di RSD Gunung Jati Kota Cirebon. Desain penelitian ini menggunakan deskriptif. Populasi dalam penelitian ini yaitu seluruh wanita  yang menderita kanker serviks berdasarkan data rekam medis di RSD Gunung Jati Kota Cirebon yang berjumlah 30 responden. Hasil penelitian berdasarkan perilaku seksual, tidak bergonta-ganti pasangan (28%) dan bergonta-ganti pasangan (6,7%), berdasarkan paritas, kurang dari 1 anak (20%) dan lebih dari 3 anak (80%), berdasarkan penggunaan pembersih vagina, menggunakan (26,7%) dan tidak menggunakan (73,3%). Bagi petugas kesehatan diharapkan dapat melakukan penyuluhan tentang kanker serviks dan pencegahan serta pemeriksaan skrining test, agar mencegar penyakit kanker serviks di usia lanjut.
Pelaksanaan Pemberian Suplemen Zat Besi Pada Remaja Putri Di Smp 12 Kota Cirebon Kecamatan Harjamukti
Authors: Lelly Euis
Published: September 2022

Salah satu kelompok yang rawan terhadap anemia adalah remaja, khususnya remaja putri. Secara global data menunjukkan bahwa 29% wanita subur mengalami anemia sedangkan wanita usia 15-49 tahun (produktif) mencapai 38%. WHO menargetkan pada tahun 2025 penurunan 50% kejadian anemia pada wanita usia produktif. Tujuan penelitian ini dilakukan untuk mengetahui gambaran pelaksanaan pemberian suplemen zat besi pada remaja putri di SMP 12 Kota Cirebon Kecamatan Harjamukti Tahun 2019. Puskesmas Kalitanjung presentasi remaja putri mendapat Tablet Tambah Darah (TTD) sebesar 57,8%, target remaja putri mendapat Tablet Tambah Darah (TTD) di Kota Cirebon sebanyak 100%.Jenis penelitian yang digunakan adalah metode deskriptif. Populasi yang digunakan dalam penelitian ini adalah remaja putri di SMP 12 yaitu sebanyak 305 orang dengan sampel sebanyak 305 responden. Instrumen yang digunakan dalam penelitian ini adalah lembar cheecklist dari data absen kelas SMP 12 bulan Juli tahun 2019.hasil penelitian menunjukan sebagian besar remaja dengan remaja putri yang mendapat, meminum dan pelaksanaan pemberian suplemen zat besi sebesar 282 orang (92,5%) serta yang tidak mendapat, meminum, dan pelaksanaan pemberian suplemen zat besi sebesar 23 orang (7,5%). Anemia gizi pada remaja adalah kurangnya asupan zat besi, disebut anemia gizi besi (AGB). Untuk itu diharapkan remaja dapat mengetahui tentang gejala anemia yang terjadi saat masa remaja, sehingga dapat di cegah dengan cara meminum suplemen zat besi, melakukan pemeriksaan Hb dan mengubah gaya hidup.
Pengaruh Teknik Relaksasi Napas Dalam Terhadap Penurunan Nyeri Haid Pada Remaja Putri Di Wilayah Kerja Uptd Puskesmas Panglayungan Kota Tasikmalaya
Authors: Rica Arieb  , Kunnati
Published: September 2022

Indonesia angka dismenorea sebesar 64,25% yang terdiri dari 54,89% dismenore primer dan 9,36% dismenorea sekunder. Biasanya gejala dismenorea primer terjadi pada wanita usia produktif 1-5 tahun setelah mengalami haid pertama dan wanita yang belum pernah hamil. Tujuan penelitian ini untuk mengetahui pengaruh teknik relaksasi napas dalam terhadap penurunan rasa nyeri haid pada remaja putri di wilayah kerja UPTD Puskesmas Panglayungan Kota Tasikmalaya. Metode penelitian ini menggunakan desain penelitian analitik eksperimental jenis pre eksperimental dengan pendekatan pretest-post test one group design. Populasi dalam penelitian ini adalah semua remaja putri yang mengalami nyeri haid di UPTD Puskesmas Panglayungan Kota Tasikmalaya yaitu sebanyak 50 responden dan  teknik pengambilan sampel menggunakan non probability sampling yaitu purposive sampling. Teknik pengumpulan data yang digunakan dalam penelitian ini yakni yaitu data primer dan data sekunder. Instrument penelitian ini menggunakan wawancara, observasi,dan angket (kuesioner) dan data di analisa secara univariat dan bivariate. Tempat penelitian dilakukan di UPTD Puskesmas Panglayungan Kota Tasikmalaya dan waktu penelitian akan dilakukan pada bulan Mei 2020. Hasil penelitian ini menunjukkan bahwa Ada pengaruh Teknik Relaksasi Napas terhadap Nyeri Haid pada remaja putri di UPTD Puskesmas Panglayungan Kota Tasikmalaya Tahun 2020 dengan hasil uji statistic dengan  uji t tes berpasangan (paired sample t – test)   diperoleh hasil p = 0,002 yang berarti p < 0,05. Hasil penelitian ini hendaknya dapat menjadi bahan perbandingan bagi peneliti yang akan datang dalam melakukan penelitian berikutnya tentang teknik relaksasi nafas dalam terhadap nyeri haid  pada remaja putri terutama mengenai variabel-variabel penelitian yang belum diteliti.
Hubungan Antara Penggunaan Kontrasepsi Suntik Dengan Perubahanberat Badan Pada Akseptor KB Suntik Di BPS Elly Suhaeliah, S.ST Kota Cirebon
Authors: Kunnati  , Rica Arieb
Published: September 2022

Kontrasepsi suntik memiliki kelebihan dan kekurangan. Kekurangan dari kontrasepsi suntik adalah terganggunya pola haid diantaranya adalah amenorrhea, menoragia dan muncul bercak (spotting), dan perubahan berat badan. Tujuan penelitian ini adalah untuk mengetahui hubungan antara penggunaan kontrasepsi suntik dengan perubahan berat badan pada akseptor KB suntik di BPS Elly Suhaeliah, S.ST kota cirebon tahun 2012. Metode penelitian yang akan digunakan adalah metode penelitian survey analitik (korelasioanal), dengan menggunakan pendekatan cross sectional.  Populasi dalam penelitian ini adalah seluruh akseptor KB suntik di BPS Elly Suhaeliah, S.ST yaitu sebanyak 195 orang. Yang menjadi sampel pada penelitian ini adalah akseptor KB suntik yang periksa di BPS Elly Suhaeliah,S.ST pada tanggal 18 – 22 Juli 2012 yaitu berjumlah 34 orang. Teknik pengambilan sampel yang digunakan pada penelitian ini adalah Nonrandom sampling, jenisnya yaitu Accidental sampling. Data yang di ambil berupa data primer, dan instumen pengumpulan data yang digunakan yaitu kuesioner. Dari hasil penelitian menunjukkan bahwa Pengguna kontrasepsi suntik 3 bulan berjumlah lebih banyak yaitu sejumlah 25 orang dengan persentase 74%. Dan responden yang mengalami perubahan berat badan berjumlah lebih banyak yaitu 26 orang dengan persentase 77% . Hasil uji statistik diperoleh nilai P value sebesar 0,013 < dari nilai α (0,05) dimana hal ini berarti “Ha diterima dan H0 ditolak”, maka terdapat hubungan antara penggunaan kontrasepsi suntik dengan perubahan berat badan.Diharapkan tenaga kesehatan dapat memberikan penyuluhan tentang efek samping dari pemakaian alat kontrasepsi suntik
Peran Tenaga Kesahatan Terhadap Pengetahuan Ibu Hamil Tentang Buku Kia (Kesehatan Ibu Dan Anak) Di Puskesmas Gajah Mada Tahun 2020
Authors: Apriyanti Sihole  , Heru Santosa  , Lubis Zulhaida
Published: September 2022

Buku KIA merupakan alat untuk mendeteksi secara dini adanya gangguan atau masalah kesehatan ibu dan anak, alat komunikasi dan penyuluhan dengan informasi yang penting bagi ibu dan keluarga dan masyarakat mengenai pelayanan kesehatan ibu dan anak termasuk rujukannya dan paket (standar) pelayanan KIA, gizi, imunisasi dan tumbuh kembang balita. Cakupan kepemilikan buku KIA di Puskesmas Gajah Mada sebesar 71,09% dengan jumlah kematian ibu 1 orang akibat pendarahan. Penggunaan buku KIA selama puluhan tahun di Indonesia belum sepenuhnya dapat menurunkan angka kematian ibu dan anak sesuai dengan standar WHO ( World Helath Organization). Penelitian ini merupakan penelitian kuantitatif dengan desain cross sectional melalui metode analitik. Jumlah responden adalah  51 orang. Data peran tenaga kesehatan diperoleh dengan kuesioner. Uji statistik analisisa menunjukkan bahwa data nilai p value  peran tenaga kesehatan 0,99% (p value>0,05) terhadap pengetahuan ibu hamil tentang buku KIA. Sehingga dapat disumpulkan bahwa tidak ada pengaruh peran tenaga kesehatan dengan pengetahuan ibu tentang buku KIA.
Monitoring Profil Berkas Elektron Menggunakan Sensor Chatode Ray Tube
Authors: Fanani Fajar , Hananto Farid Samsu , Hastuti Erna
Published: September 2022

Telah dilakukan rancang bangun monitoring profil berkas elektron menggunakan chatode ray tube menggunakan metode bahan pendar. Variasi tegangan inputan dilakukan pada 203 V, 205 V, 208 V, 210 V, 212 V, 213 V, 215 V, 218 V dan 220 V. Tegangan inputan mempengaruhi perubahan pada diameter, intensitas iluminasi dan dosis serap berkas elektron yang ditunjukkan hasil pengukuran pada nilai diameter dan intensitas ilumninasi berkas elektron yang berbanding lurus dengan kenaikan tegangan input. Sedangkan hasil pengukuran nilai dosis serap berkas elektron terjadi kenaikan pada variabel tegangan 203 V hingga 210 V dan mengalami penurunan pada tegangan 212 V, Kemudian mengalami kenaikan yakni semakin tinggi tegangan inputan, semakin besar pula nilai dosis serap berkas elektron. Hasil akurasi data pengukuran nilai dosis serap berkas elektron pada cathode ray tube dengan data SNI radiasi untuk pengawetan bahan makanan, yaitu pada variabel tegangan 208 Volt, 215 Volt dan 220 Volt memenuhi syarat untuk radiasi pengawetan makanan, diantaranya dapat digunakan untuk menghambat pertunasan selama penyimpanan pada umbi lapis dan umbi akar, menunda pematangan dan memperpanjang masa simpan pada sayur dan buah segar selain umbi lapis dan umbi bakar. Dan terakhir, digunakan untuk perlakuan karantina dan membasmi serangga.
Bibliometric: Social Media Marketing and Adoption in Indonesia
Authors: Sary Kezia Arum , Hudayah Syarifah , Abidin Zainal , Kuleh Yohanes
Published: September 2022

This study conducts a bibliometric analysis of social media marketing and adoption in tourism development by reviewing previous studies in the world and Indonesia published in the Scopus database. The data obtained were analyzed using a quantitative approach to provide a representative picture in line with the practicality of bibliometric analysis in assessing the output, organization, authorship, and characteristics of topics. The focus was placed on the articles published between 2012 and 2021 and the findings showed an increasing interest in the studies related to social media marketing and social media adoption as well as an evolution of related academic research.