bluuebunny/crossref_metadata_2025 huggingface dataset:
Local Knowledge Conservation Based on Indigenous Tourism Village
Authors: Pratama Andhika Yudha , Alfaqi Mifdal Zusron , Mawarti Rista Ayu , Shofa Abd. Mu'id Aris
Published: May 2024

In the current era of globalization, there are many new cultures have emerged from the outside and are spread in all aspects of life. This can be worrying about the condition of local wisdom in several areas of traditional villages in Indonesia, which, with the development of technology in the era of globalization, is feared to have an impact on the behavior of people who are increasingly abandoning local wisdom. The purpose of this paper is not only commercial, but also to preserve the local culture so that it is not degraded by the changing times in the era of globalization. The method used in this research is a literature case study in the form of traditional tourism villages in Indonesia, such as Cirendeu Traditional Village, Ngadas Traditional Village, Tenganan Traditional Village, Kemiren Traditional Village, and Naga Traditional Village. The results of this study reveal how important the role of tourism villages is. These villages serve as the main activity center for local residents who already have a deep understanding of local wisdom values, where they can support each other and apply these traditional teachings in their daily activities, following in the footsteps of their predecessors. In the framework of further research, it is recommended to look for ways to improve accessibility, both in terms of the ease of reaching tourism village locations and communicating with the local government. This action has the potential to have a greater positive impact on the development and sustainability of these traditional tourism villages while allowing more people to interact with its rich culture.
Keywords: globalization, local knowledge, traditional villages
Introducing Indonesian Art in the English Target Text through Translation
Authors: Mahmud Erlina Zulkifli , Ampera Taufik
Published: May 2024

Indonesia is a country of various cultures representing each ethnic group around the archipelago. Each culture creates its own art ranging from its music including its traditional musical instruments, dance, its architecture, to its martial arts. The way people in each ethnic group name their art products is specifically unique. It may not contain any general characteristics as other cultures have. The uniqueness can only be introduced to other cultures within the nation as well as outside of the nation through a language understood by them. It is therefore that the information can be shared with others through translation work as the equivalents given in the target text. This research uses some Indonesian novels and their translation into English as the data source. Using the descriptive qualitative method, this research is aimed at revealing Indonesian art found in Indonesian novels and describing how they are shown in the English target text as their equivalents. How the author in the source text expresses the art is the first research question and what strategies are used in delivering the art through translation becomes the second research question. The results show that not all the authors of the source novels are aware that the art they mention in the novel need to be added with more information, and it is identified that the dominant strategy of translation used in translating the name regarding the art is translation using a loan word or loan words plus explanation.
Keywords: Indonesian art, source text, strategies of translation, target text, translation
The Role of Tranexamic Acid (TXA) In Spine Surgery for Patients with Comorbidities in Basra/Iraq
Authors: Al-Mahfoodh Ali B. , F. Lui Darren , A. Hamdan Thamer
Published: May 2024

Background: Blood loss occurs frequently and remains a challenge in spinal surgery. As significant intra and postoperative hemorrhage negatively affects patient outcomes by increasing coagulopathy, postoperative hematoma, and anemia. The need for allogenic blood transfusions can lead to potential transfusion reactions and infections, in addition to increasing long-term mortality rates. Although there are many randomized control trials and meta-analysis investigating the role of tranexamic acid (TXA), we could not find any study that investigated the role of TXA in patients with medical comorbidities. Therefore, tackling the role of TXA in patients with single or multiple comorbidities is of valuable outcome to our locality as most of the patients have indeed associated comorbidities.
Objectives: to investigate the role of tranexamic acid in decreasing perioperative blood loss in patients with multiple comorbidities as compared to otherwise healthy individuals.
Patients and methods: A single center randomized control trial. We included patients that were about to undergo simple decompressive surgeries for lumbar canal stenosis and fixation with decompression for spondylolisthesis. Patients were randomly categorized into cases (who received TXA) and controls who received NS. Patients then were subcategorized according to comorbidities and types of surgeries. Intraoperative blood loss was calculated using the suction drain and the gauze while the post operative bleeding was calculated using the drain output.
Results: There was 441.84 ml (49.6 %) decrease in intraoperative bleeding for patients who received TXA as compared to controls regardless the type of surgery and regardless the presence or absence of comorbidities. Hypertensive patients had 52.7 % reduction in intraoperative bleeding when received TXA, Diabetic patients showed 44.4 % reduction in bleeding, Obese patients showed 51.1% reduction and patients with multiple comorbidities showed 51% reduction in intraoperative bleeding while healthy individuals showed 38.9% reduction in intraoperative bleeding.
Conclusion: TXA was even more effective in decreasing intraoperative bleeding in patients with multiple comorbidities as compared to healthy individuals.
Post COVID 19 Myocarditis: Clinical Case Series
Authors: ZOUZOU Hanane
Published: May 2024

Corona virus disease 2019 infection exhibits a tropism for the respiratory tract, however several cardiac damages have been reported, such as coronary disease, cardiac arrhythmias and myocarditis; this latter has become more frequent after the outbreak of the COVID-19 pandemic, and may be the only manifestation of COVID 19 infection, the diagnosis is not always obvious especially for focal myocarditis and can be misdiagnosed as an acute coronary syndrome in some patients.
We reported five patients, admitted between June 2020 and January 2021, in our cardiology department for isolated acute focal myocarditis secondary to COVID 19 infection without respiratory or other damages, the diagnosis was not evident at first, but further investigations such as: electrocardiographic evolution, magnetic resonance imagery, coronary computed tomography angiography, and COVID 19 antibody testing, were in favor of the diagnosis of focal myocarditis secondary to COVID 19 infection.
Cardiac magnetic resonance imaging showed, delayed contrast enhancement in the lateral wall of the left ventricle, for all five patients, so fibrosis is preferentially located in the lateral wall, and the outcome was favorable without hemodynamic or arrhythmic complications.
Aplicación foliar suplementaria de Boro, Manganeso y Molibdeno como inductores de crecimiento, rendimiento y concentración de fitoquímicos en el cultivo de tomate
Authors: García-Terrazas Mariana Isabel , Benavides-Mendoza Adalberto , González-Morales Susana , Medrano-Macías Julia , Cabrera-De La Fuente Marcelino
Published: May 2024

En el estudio se evaluó la aplicación foliar suplementaria de productos comerciales líquidos de B+3 (Basfoliar® con 13 % de B), Mn+2 (CRECITEC Mn® con 5 % de Mn) y Mo+6 (MOLIBION® con 9.2 % de Mo) sobre el rendimiento y fitoquímicos de tomate. Los tratamientos fueron: B+3 (1 mL L-1), Mn+2 (2 mL L-1), Mo+6 (1.5 mL L-1), sus interacciones (B+3+Mn+2, B+3+Mo+6, Mn+2+Mo+6 y B+3+Mn+2+Mo+6) y un testigo cada 15 d después del trasplante. Se utilizo un diseño de bloques completos al azar con ocho tratamientos y 10 repeticiones. Los tratamientos no modificaron el rendimiento, sin embargo, B+3+Mo+6 mejoró el diametro ecuatorial del fruto. Para altura de planta los tratamientos superaron al control a excepción de B+3 y Mn+2, y el número de hojas se incrementó con Mn+2 y Mo+6. El tratamiento de Mo+6 aumentó el peso seco total. En fruto, Mn incrementó las proteínas, B+3+Mo+6 y Mn+2 +Mo+6 disminuyeron los fenoles, B+3, Mo+6 y Mn+2+Mo+6 aumentaron los flavonoides y B+3+Mn+6 y Mn+3+Mo+6 disminuyeron el glutatión. B+3+Mo+6 incrementó licopeno, pero disminuyó el β-caroteno. Para capacidad antioxidante lipofílica, B+3+Mn+2 la incrementó y B+3+Mo+6 la disminuyó. La aplicación suplementaria de estos microelementos es adecuada para incrementar fitoquímicos en cultivos, sin afectar rendimientos.
Fear as a Political Tool: A Critical Analysis of Representative Marjorie Taylor Greene’s Fearmongering Narratives
Authors: Kwiatek Gabriela
Published: May 2024

This paper examines the fearmongering narratives employed by Representative Marjorie Taylor Greene from Georgia in her political strategy. By analyzing sources, such as campaign materials, legislative proposals, and press releases through a content analysis method, the paper identifies three primary fear-based narratives this politician uses: threats to the country, threats to freedom, and threats to children. Moreover, the impact of fearmongering in Rep. Greene’s electoral strategy and its success in Georgia’s 14th congressional district, known for its conservative leanings, are also explored. By understanding the effectiveness of fearmongering, this research sheds light on the dynamics of contemporary political discourse in the United States and its potential consequences.
Ecoficciones y procesos artísticos: la producción de obras artísticas y la relación simbólica con el territorio habitado y construido
Authors: Villavicencio Monti Karla Paola , Hernández Calvo Max Alfredo , Escribens Bacigalupo Alessandra
Published: May 2024

En este artículo se exponen las diversas formas de representación de lo que se denominará «ecosistemas ficcionales». Estos se refieren a entornos imaginarios que se desarrollan mediante representaciones visuales, destacando su relevancia para la creación, desarrollo y mantenimiento de un vínculo con el territorio habitado. Este lazo se considera fundamental para la construcción de una sociedad que cuestione las subjetividades arraigadas en la convivencia con el entorno natural, humanizado y colectivo. De esta manera, se establece una línea explicativa para abordar la interrogante: ¿Es viable emplear elementos de representación visual para la creación de «ecosistemas ficcionales» que contribuyan a cuestionar la relación que se construye con los entornos naturales y humanizados en contemporaneidad y sus respectivas problemáticas? La respuesta se estructura a través de una metodología de dos fases de análisis. Se traza una línea explicativa mediante propuestas artísticas en Perú, abordando diversos soportes y medios como pintura, dibujo, instalación y videoarte. La primera fase titulada Territorio ritualizado y creación, se centra en la relación entre las vivencias personales de los y las artistas en el territorio y sus procesos creativos. En la segunda fase Territorio e imaginarios culturales, se destaca la relación intrínseca entre las experiencias establecidas en la anterior fase y la construcción de imaginarios que permiten cuestionar el entorno cultural y ético. Se enfatiza la importancia y el rol fundamental de las representaciones mencionadas como un puente para comprender mejor las subjetividades presentes en los ecosistemas naturales y los ecosistemas artificiales o humanizados. Esta metodología será explicada mediante el desarrollo de cuatro proyectos específicos: Abglutia, Peligro de extinción, Natural Sense Making y finalmente Pestes.
A través del análisis de estos proyectos, se reconoce la utilidad y necesidad de las representaciones visuales de estos ecosistemas ficcionales para desarrollar una visión crítica que promueva la introspección y el cuestionamiento sobre la relación con nuestro entorno natural y los ecosistemas que influyen en él. Asimismo, posibilitan la incorporación de una relación simbólica con el territorio que se habita y se construye a través de las interacciones colectivas.
A Study of the Population Density of Aphids and Coccinella septempunctata on Different Wheat Cultivars
Authors: Al-Hamawandy Shaymaa A.K. , Najm S.M. , Reza N. Abdul
Published: May 2024

Background: Wheat is considered one of the primary and strategic grain crops in the world in terms of production and importance. The increment in both quantity and quality of wheat production renders it susceptible to various pests and diseases, including both insects and non-insect pests. The study aims to study the extent of infection of the IPA 99, IPA 22 and Abu Ghraib wheat varieties with aphids. Methods: A general survey of aphids on Abu Ghraib, IPA 99 and IPA 22 wheat varieties was carried out in the fields of the College of Agriculture/ University of Baghdad in Abu Ghraib during the growing season 2021-2022. Result: The results of the field survey indicated the presence of three species of aphids on the wheat crops belonging to the order Hemiptera and the family Aphididae: the wheat aphid [Schizaphis graminum (Rondani)], the oat aphid [Rhopalosiphum padi (L.)] and the corn aphid (Rhopalosiphum maidis). Wheat and oat aphids were the most commonly found on the crops. The presence of aphids on the plants was affected by the predominant environmental conditions like temperature, humidity, the chemical components of the host plants and the interactions between these factors. Additionally, we identified one type of predator belonging to the order of Coleoptera, the seven-spotted ladybug (Coccinella septempunctata), which was observed to be affected by the pest density. Aphids are a major pest of wheat in Iraq and they can cause significant losses of crops if their population is not controlled.
Soil Chemical Properties and Nutrient Dynamics under Different Legume-based Agroforestry Systems in Semi-arid Conditions of Haryana
Authors: . Pankaj , Bhardwaj K.K. , Yadav Rajni , Goyal Vishal , . Sonia , Bhardwaj Sumit , Beniwal R.S.
Published: May 2024

Background: In order to support livelihoods, enhance food security, restore ecosystem services, and reduce pressure on forests, soil fertility can be improved by utilizing alternative land-use systems, such as agroforestry. Methods: The present study was conducted to investigate the effect of different agroforestry systems on soil chemical properties and nutrient availability (macro and micro) during different seasons in Hisar, Haryana. Different systems include Poplar (Populus deltoides), Eucalyptus (Eucalyptus tereticornis), Melia (Melia composita), Shisham (Dalbergia sissoo) based agroforestry system (Cowpea-Wheat) and sole cropping of Cowpea-Wheat (as control). Soil samples were collected from 0-15 and 15-30 cm of soil depth during five seasons i.e., winter, spring, summer, rainy and autumn. Result: Soil EC, SOC and available macronutrients and micronutrients were significantly affected by the depth of sampling, systems and seasons while soil pH was not significantly affected by seasons. Lower soil pH and EC was observed from agroforestry systems as compared to sole cropping. Soil Organic Carbon, availability of N, P, K and S was significantly higher under tree based systems as compared to control. Maximum DTPA extractable Mn, Zn and Cu was observed under poplar based system while highest DTPA extractable Fe was observed under Melia based system during both the years. Significantly higher SOC and nutrient availability was observed during autumn, rainy and spring seasons as compared to winter and summer seasons, while reverse trend was observed for soil pH and EC among the seasons. Soil Organic Carbon, availability of macro and micronutrients decreased with increase in soil depth. Overall, the soil chemical properties and nutrient status of soil were comparatively better under tree based systems than sole cropping of Cowpea-Wheat.
A research proposal to examine psychological factors that influence financial planning for retirement in China
Authors: Han Ren , Sang Lim Thien
Published: May 2024

The life expectancy rate of individuals worldwide has risen, and China is not excluded. Combined with an aging population, increasing pressure on the pension fund system, and a lack of savings, it poses a significant challenge to financial security unless measures are taken to improve individuals’ planning and financial well-being in retirement.  This study aims to examine the psychological factors that influence individuals' FPR, thereby expanding the explanatory models for retirement savings decisions and behaviors. Using the CWO Model and supported by image Theory and the 3M Model, this research focuses on how the interaction between future time perspective, risk tolerance, retirement goal clarity, subjective financial literacy and objective financial literacy as psychological characteristics influence individuals' FPR. To obtain meaningful results, back translation was used to check the accuracy of the preliminary translation of research instruments. This translation method was also combined with the pretest method of expert reviews and cognitive interviews to increase the validity of the survey questionnaire. A purposive sampling technique will be applied to collect data from adults who are over 23 years old and have a certain income stream in six cities in China. The Structural Equation Modelling software will be used to examine the hypotheses of direct and mediating effects. This study has implications for financial market regulators, policy makers, and consumers.
Keywords: CWO model; decision-making; financial planning; financial literacy; psychological factors; retirement
THE COUNTRY NAME AND POLITICAL RECONSTRUCTION OF AFGHANISTAN
Authors: Peitao Huang
Published: May 2024

Looking back at the history of regime changes in Afghanistan, Afghanistan's political reconstruction after political instability is often accompanied by renaming the country. This phenomenon reflects the close connection between political reconstruction and the name of the country. A hypothesis was proposed to explain this phenomenon: The renaming of the country is a microcosm of Afghanistan's political reconstruction process. By analyzing the composition of the country's name, we can generally understand the country's political reconstruction process. The analysis of the country's name helps to explain the results of the political reconstruction of Afghanistan in history and to make a reasonable prediction of the results of the ongoing political reconstruction. To test this hypothesis, this paper made a historical analysis of the period of the Afghan People's Democratic Party in power and the US-backed bourgeois-democratic political period. It reviewed the composition of the country's name and the goals and results of political reconstruction in these two historical periods. Finally, this paper, in light of the elements in the name of “The Islamic Emirate of Afghanistan”, envisioned the current Taliban-led political reconstruction in Afghanistan.
Un ministro homicida: polémicas en la prensa norteamericana en torno al caso de Jacob S. Harden (1860)
Authors: Luciani Frederick
Published: May 2024

This study examines the case of Jacob S. Harden, a young Methodist preacher who in 1860 was tried, convicted, and executed in a rural town in the state of New Jersey, United States, for the murder of his wife. The study focuses on the controversies raised in the North American press regarding the case, and how these controversies reflected some evolving ideas in the United Sates at the time: ideas regarding criminal psychology, the causes of criminality, the possibility of prison rehabilitation, the relationship between the clergy and radical movements of reform and social experimentation, and the relative value of public executions as a form of moral admonition for the masses.
Are There Serial Verb Constructions in Old English? A New Perspective on the Changes in Verbal Complementation
Authors: Ojanguren López Ana Elvira
Published: May 2024

This article discusses the existence of serial verb constructions in Old English and explores the complementation of aspectual and control verbs as well as other related constructions. The discussion of the Old English data finds remarkable differences with respect to the syntactic configurations of Present-Day English that are described as serial by Roberts (2010). Although the range of serial constructions is more restrictive in Old English, at least with aspectual verbs, the analysis of verbal complementation from the perspective of serialisation allows us to bring other convergent constructions to the discussion, including configurations with linked infinitives and participles in predicative constructions and configurations with pre-modals and the causative verb dōn ‘to do’.
El impacto de la migración en la fraseología del español en los Estados Unidos: un estudio comparativo de California y Nueva York
Authors: Ramírez Rodríguez Pablo
Published: May 2024

This comparative study aims to analyse the impact of migration on Spanish phraseological diatopic variation in two American states: California and New York. For this purpose, a sample of verbal locutions extracted from the Hispanic press in both regions was collected, a phraseological corpus of 362 units was created and compared with the verbal locutions of mainland standard Spanish. The phraseological comparison was carried out from various fields of linguistic knowledge, considering sociolinguistic and cognitive contributions to phraseology. The results show that, in both California and New York, there is significant diatopic variation in phraseology compared to standard Spanish. This variation, a result of the demographic characteristics of each region, is largely attributed to the linguistic influence present in both regions, especially English and other Hispanic variants, such as Mexican Spanish in the case of California and Caribbean Spanish in the case of New York. This paper aims to provide a significant contribution to the field of applied linguistics and sociolinguistics in the context of migration and the evolution of the Spanish language in the United States.
La polémica sobre la existencia de una poesía antillana y la presencia del tema negro en la literatura puertorriqueña (1932-1933)
Authors: Reyes de las Casas Sabina
Published: May 2024

The objective of this article is to study the texts on the polemic generated between 1932 and 1933 about the existence of Antillean poetry and the presence of the black theme in Puerto Rican national literature. The main texts of the controversy have been analysed from the perspective of socio-critical theory to identify the social-historical themes addressed by the writers involved. This research has made it possible to establish a relationship between the debate that arose and the conception of the Puerto Rican national imaginary defended by its main participants: Luis Palés Matos and José I. de Diego Padró.
Traumatic Floating Total Hip Arthroplasty
Authors: Brodell James D. , Newman Jared M. , Soin Sandeep P.
Published: May 2024

Update:

This article was updated on July 19, 2024 because of a previous error. One author's name was incorrect. The correct name is Jared M. Newman.

An erratum (JBJS Case Connect. 2024;14[3]:e24.00046ER) has been published for this article.

Case:

A 58-year-old woman with medical history of a left total hip arthroplasty performed by the direct anterior (DA) approach 2 years prior presented with left hip pain. She was found to have sustained a transverse Vancouver C periprosthetic femur fracture and an unstable periprosthetic pelvic fracture.

Conclusions:

This patient's case represents a previously not reported injury about a total hip arthroplasty—with disruption distal to the femoral implant and proximal to the acetabular implant, with the implant-to-bone interface unaffected. This case may guide future treatment of similar injuries.
Enhancing Sugar Sales Through Quality Improvement and Customer Preferences
Authors: Firdaus Handika , Sukmono Rita Ambarwati
Published: May 2024

This study investigates factors influencing the selling price of PT PG Candi Baru's sugar products, utilizing the Importance Performance Analysis (IPA) - Kano method and Quality Function Deployment (QFD). Despite consistent sales growth, the company's selling value needs enhancement. Findings reveal PT PG Candi Baru's superiority in product design, packaging durability, and availability compared to competitors. However, deficiencies in the weight measurement parameter of the 1 kg retail sugar product are noted. Renewing the 1 kilogram retail machine, integrated with a scale with an error rate of less than 0.5, is proposed to address this issue. Additionally, tightening quality control selection related to weight measurement is recommended. This research offers insights for improving PT PG Candi Baru's product competitiveness, contributing to the understanding of customer preferences and suggesting actionable strategies for the company's development.
Hightligh:

Customer priorities identified: IPA-Kano and QFD methods used.
Product superiority: Design, packaging, availability excel.
Renewal recommendations: Update machine, improve quality control for weight.

Keywords: Sugar products, Selling price, Quality improvement, Industrial engineering, Customer preferences
Social Media's Impact on Global Purchasing Decisions via Key Insights
Authors: Sakdiyah Ni’matus , Fitriyah Hadiah
Published: May 2024

This study examines the influence of social media on purchase decisions, focusing on entertainment, trendiness, and electronic word of mouth (E-WOM), with follower count as an intervening variable. Conducted on followers of the "SECACA.ID" social media account, the research utilized a quantitative approach with 100 respondents. Results indicate that entertainment significantly affects purchase decisions independently, while trendiness influences both directly and indirectly. E-WOM requires follower count as an intervening variable to impact purchase decisions. The findings suggest businesses focus on enhancing content quality and attractiveness on social media to influence consumer behavior positively, considering follower count as well. Further research with larger samples and broader contexts is recommended to validate and extend these findings.
Highlight:

Entertainment Directly Affects Purchases
Follower Count Moderates E-WOM Impact
Enhance Content Quality for Better Influence

Keywords: Social media, Purchase decisions, Follower count, Entertainment, E-WOM
Evaluating Grade 5 Teacher Competence Provides Global Education Insights
Authors: Ummah Siti Roudotul , Wahyuni Akhtim
Published: May 2024

This qualitative study examines the professional competence of Grade 5 teachers at SDN GELAM 1 Candi through interviews, observations, and documentation. The research aims to assess subject mastery, teaching structures, and ongoing professional development. Findings suggest teachers demonstrate competence but have room for improvement in aligning with defined indicators. Emphasizing continuous development, creative content delivery, and technology integration can enhance teaching practices and student learning outcomes.
 
Highlight:

Teacher Competence Assessment: Evaluating subject mastery and teaching effectiveness.
Ongoing Professional Development: Emphasizing continuous improvement and training.
Technology in Teaching: Leveraging tech for enhanced educational practices.

 
Keyword: Professional competence, Grade 5 teachers, Qualitative research, Educational development, Technology integration.
Finger Painting Revolutionizes Early Childhood Education by Boosting Fine Motor Skills
Authors: Husniah Mufarihun Nuril , IFFATUR ROCMAH LULUK
Published: May 2024

This classroom action research investigates the efficacy of finger painting activities in enhancing the fine motor skills of 5-6-year-old children at Ittihadul Ummah Ngoro Kindergarten. Conducted over two cycles with 20 students in Group B, the study employs observation, tests, interviews, and documentation for data collection. Results indicate a notable improvement in children's fine motor skills, with average achievements rising from 61% to 78% between Cycle I and Cycle II. The findings underscore the value of integrating sensory-rich, hands-on activities like finger painting into early childhood education to support holistic development and academic readiness.
Highlight:

Finger painting enhances fine motor skills.
Integration of sensory-rich activities in early childhood education.
Importance of holistic development for academic readiness.

Keywoard: Fine motor Skills, Finger Painting, Early Childhood Education, Sensory-rich Activities, Academic Readiness.
Pengembangan E-modul Pubertas Untuk Melatihkan Literasi Digital Peserta Didik Madrasah Ibtidaiyah
Authors: Astuti Yanti , Suyidno Suyidno , Suryajaya Suryajaya , Jamilah Nor
Published: May 2024

Digital literacy development is needed to live, learn and work in the era of digital technology. However, this literacy is lacking in schools. Therefore, this research aims to produce a puberty e-module using project-based learning that is feasible to improve students' digital literacy. The research design was adapted from Tessmer's formative evaluation model, which is limited to self-evaluation, expert review and one-to-one evaluation. Data collection techniques used e-module validation instruments by 3 experts and 2 practitioners and content readability assessments by students. The results showed the validation results in the aspects of design, format, material, language, presentation, and innovation were 94, 97, 94, 98, 94, and 98 with very valid criteria. In addition, the readability of the e-module content with very practical criteria. Thus, the puberty e-module using project-based learning developed is feasible to use to improve students' digital literacy.
Pengembangan literasi digital dibutuhkan untuk hidup, belajar, dan bekerja di era teknologi digital. Namun, literasi tersebut kurang dilatihkan di sekolah. Oleh karena itu, tujuan penelitian ini adalah menghasilkan e-modul pubertas menggunakan project-based learning yang layak digunakan untuk meningkatkan literasi digital peserta didik. Desain penelitian ini diadaptasi dari evaluasi formatif model Tessmer, yang dibatasi pada self evaluation, expert review dan one to one evaluation. Teknik pengumpulan data menggunakan instrumen validasi e-modul oleh 3 pakar dan 2 praktisi, serta penilaian keterbacaan isi oleh peserta didik. Hasil penelitian menunjukkan hasil validasi pada aspek desain, format, materi, kebahasaan, penyajian, dan inovasi berturu-turut sebesar 94, 97, 94, 98, 94, dan 98 dengan kriteria sangat valid. Selain itu, keterbacaan isi e-modul dengan kriteria sangat praktis. Dengan demikian, e-modul pubertas menggunakan project-based learning yang dikembangkan adalah layak digunakan untuk meningkatkan literasi digital peserta didik
Enhancement of the Structure and Biochemical Function of Cyclomaltodextrinase from the Anoxybacillus flavithermus ZNU-NGA with Site-directed Mutagenesis
Authors: Mirzaee Ziba , Jafarian Vahab , Khalifeh Khosrow
Published: May 2024

This study was conducted to examine the role of the central domain of cyclomaltodextrinase (GenBank: KT633577.1) in terms of stability, substrate specificity, becoming dodecameric form, and enzyme activity. To this end, H403R/L309V double-point mutation and T280Q single-point mutation were performed at the central domain and (β/α)8-barrel. The results indicated that the activity of the H403R/L309V mutant at the optimal pH and temperature increased by about 25% and 40%, respectively, compared to the wild enzyme. Plus, the irreversible thermal inactivation of the H403R/L309V mutant at 60℃ and 160 min was approximately twice of the wild enzyme. Both mutants underwent significant structural change relative to the wild enzyme and subsequently a significant catalytic activity. However, the catalytic efficiency (kcat/Km) of the H403R/L309V mutant increased in the presence of beta- and gamma-cyclomaltodextrin substrates compared to the wild enzyme and T280Q mutant. As a result, by applying the L309V mutant and given the smaller size of the valine, leucine spatial inhibition in the wild protein seems to decline and also it facilitates the substrate access to active site amino acids. Moreover, as gamma substrates are larger, eliminating the effect of spatial inhibition on this substrate has a greater effect on improving the catalytic activity of this enzyme.
Genome Sequencing Reveals the Presence of Five Pathogenic Bacterial Species in Wheat in Argentina
Authors: Fumero Maria Veronica , Garis Sol Belen , Alberione Enrique , Jofre Edgardo , Vanzetti Leonardo Sebastian
Published: May 2024

Wheat is a highly important food grain source in the human diet and is considered a global primary commodity. A number of bacterial diseases affect wheat production around the globe and are reported to reduce annual wheat production by about 10% and up to 40% depending on climatic conditions such as humidity and precipitations. Accurate, sensitive, and timely detection of these and other pathogens is essential for effective crop disease management. In the present study, using real-time ONT sequencing, we identified the presence of five species of pathogenic bacteria in wheat leaf lesions during a natural infection in Argentina, and sequenced and assembled their complete genomes. The isolated species were the G(+) Curtobacterium flaccumfaciens pv. flaccumfaciens and Clavibacter tessellarius, and the G(-) Xanthomonas translucens pv. undulosa, Pantoea ananatis and Pseudomonas syringae. This paper contributes with accurate data on the phylogenetic status of the five isolated species, as well as current whole-genome-scale data on the species involved, providing a basis for further application of omics strategies in the study of genetic diversity and exploration of the virulence strategies of the pathogens for future improvement of wheat health.
Preliminary study on the effect of certain weeds control strategies on the seed bank of the soil
Authors: Abusteit Ezzaldin , Absy Ragab , Ismail Abdo , Hassan Assem
Published: May 2024

Regular studies of soil seed bank can give a lot of information about different weed species that persist in experimental fields, and help in planning of different weed management strategies. In this work, two field experiments in a randomized complete block design (RCBD) were carried out at Giza Farm Station that located at Giza governorate, Egypt, to evaluate the effect of certain weed control strategies on the weeds' species seed bank in the soil during the summer season of the years 2021 and 2022. To determine all weed species in the soil seed bank, both emergence method and extracted seeds method were used. Obtained results indicated that emergence method has recorded less seedling number than those of seed extraction method, and horizontals distribution of soil seed bank at zero time, showed high significance at (p ≥ 0.01) between the experiments' replicates for most weed species and their total, while vertical distribution of soil seed bank showed no significantly differences between the two depth of 5 and 15 cm for all weed species except those of Setaria virids and Ipomia eriocarpa. Finally, the implemented strategy based on applying pre and post herbicides and mechanical at same sequence during the two successive summer seasons has reduced significantly the soil seed banks of all identified weed species and their total.
Label Free Electrochemical cDNA-Biosensor for Selective and Sensitive Detection of Canine Distemper Virus in Biological Samples
Authors: Hosea Hosea A. , Philip Joseph Y.N. , Maeda Daniel G. , Mahadhy Ally
Published: May 2024

Canine distemper, a viral disease with a global impact on various animals including dogs, foxes, wolves, lions, and leopards, requires early diagnosis for effective treatment and outbreak prevention. Common laboratory methods, such as enzyme-linked immunosorbent assay, polymerase chain reaction, and viral isolation, face challenges such as extended turnaround time, high costs, and the expertise required. This study has developed a field-based biosensor for canine distemper detection, utilizing a screen-printed carbon electrode and a computer-assisted portable potentiostat. A 30-mer oligonucleotide capture probe, designed using the Primer3 Plus software version: 3.3.0, detects hybridization with the canine distemper virus complementary strand through electrochemical analysis via differential pulsed voltammetry. The developed biosensor exhibited good linearity in quantifying the target analyte concentration (0.1 µM to 12.8 µM) with a detection limit of 0.05 µM. Specificity tests using complementary and non-complementary sequences confirm the biosensor’s accuracy. The screen-printed electrode can be reused up to eight times with a residual capacity of 93.72 ± 5.45% after regeneration using a 50 mM NaOH solution. The developed biosensor was also used to detect the canine distemper virus from biological samples after the extraction of RNA and amplification. Results aligned with reverse transcriptase polymerase chain reaction findings, showing 100% agreement. These findings support the potential development of a field-deployable portable device for effectively diagnosing canine distemper in biological samples.
Deciphering Earth’s deep mantle hemispheric geochemical dichotomy with machine learning
Authors: Li Zefeng , Ma Shang , Chen Ling , Shen Ji , Li Yunguo , Wang Wenzhong , Leng Wei
Published: May 2024

Global geochemical zoning of the mantle provides critical constraints on Earth’s internal dynamics and evolutionary history. However, whether geochemical heterogeneities in the deep mantle are dominated by the hemispheric DUPAL anomaly1,2 or by the two large low shear-wave velocity provinces (LLSVPs) has recently been debated3. Here, we employ machine learning to objectively assess the credibility of the two hypotheses on two different datasets of radiogenic isotopic records from global ocean island basalts. We observe discrepant classification accuracies for the LLSVP-based dichotomy and contradictory roles of the most characteristic 87Sr/86Sr isotopic ratio in two different datasets where the hemispheric DUPAL dichotomy remains robust and consistent. The two most important isotopic ratios, i.e., 87Sr/86Sr and 206Pb/204Pb, effectively distinguish the austral and boreal domains to the same extent as all the isotopic ratios combined. This discovery concisely defines the DUPAL anomaly in the 87Sr/86Sr - 206Pb/204Pb diagram, which highlights the key role of the Enriched Mantle 1 (EM1) component. The importance of EM1 supports the historical large-scale mass transfer of lower continental crust into the deep mantle in the Southern Hemisphere and could be attributed to widespread lithospheric delamination caused by continental collisions during Gondwana amalgamation at ~600-500 Ma. These observations illustrate how machine learning from large geochemical datasets contributes to revealing robust patterns in heterogeneous and evolutionarily deep Earth.
RETRACTED: Enhancing the low-voltage ride-through capability of a wind turbine double- fed induction generator using ANFIS controller and a crowbar circuit
Authors: Abdelaal Ashraf K.
Published: May 2024

The authors have requested that this preprint be removed from Research Square.
Estimating sensible heat flux over bare soils using surface renewal and similarity theories for unstable cases
Authors: Castellvi Francesc , Agam Nurit
Published: May 2024

A model to estimate the sensible heat flux half-hourly (H) for bare soils was derived based on surface renewal (SR) and similarity (MOST) theories, involving the land surface temperature (LST) and low-frequency measurements (wind speed and the air temperature in half an hour), HSR-LST. The dataset included semi-arid and arid climates, where the optimal surface roughness length for momentum (zom), determined from the actual friction velocity (u*) and the measurement height, ranged between 0.68 and 6.1 mm. Fixing the parameter kB-1 (=ln⁡(zom/zoh ) , where z0h is the roughness length for heat) to 2 (traditional value under neutral conditions), a non-dimensional relationship for the SR parameters was proposed. The sensible heat flux estimates were evaluated using the root mean square difference (RMSD) over the mean actual sensible heat flux (HEC), (E =RMSD/(HEC) 100%) considering (as a rule of thumb) excellent, good and moderate for E values up to 25%, 30% and 35%, respectively. For different measurement heights (ranging from 0.5 m up to 20 m), HSR-LST was in excellent, good, and moderate agreement in 6, 3 and 13 cases, respectively. Three cases had E value ranging between 37% and 39%. The sensible heat flux estimates using MOST required calibration of zom and kB-1. It is concluded that HSR-LST method is more direct requiring the wind speed, the air temperature and the land surface temperature as input.
The comprehensive SARS-CoV-2 ‘hijackome’ knowledge base— reveals significant changes in host cell protein expression and activation by multiple SARS-CoV-2 variants
Authors: Varjosalo Markku , Huuskonen Sini , Liu Xiaonan , Redchuk Taras , Salokas Kari , Lundberg Rickard , Maljanen Sari , Belik Milja , Reinholm Arttu , Kolehmainen Pekka , Tripathi Garima , Laine Pia , Belanov Sergei , Auvinen Petri , Vartiainen Maria , Laine Larissa , Österlund Pamela , Julkkunen Ilkka , kakkola Laura
Published: May 2024

The continuous evolution of SARS-CoV-2 has led to the emergence of several variants of concern (VOCs) that significantly affect global health. This study aims to investigate how these VOCs affect host cells at proteome level to better understand the mechanisms of disease. To achieve this, we first analyzed the (phospho)proteome changes of host cells infected with Alpha, Beta, Delta, and Omicron BA.1 and BA.5 variants over time frames extending from 1 to 36 hours post-infection. Our results revealed distinct temporal patterns of protein expression across the VOCs, with notable differences in the (phospho)proteome dynamics that suggest variant-specific adaptations. Specifically, we observed enhanced expression and activation of key components within crucial cellular pathways such as the RHO GTPase cycle, RNA splicing, and ER-associated degradation (ERAD)-related processes. We further utilized proximity biotinylation Mass Spectrometry (BioID-MS) to investigate how specific mutation of these VOC influence viral-host protein interactions. Our comprehensive interactomics dataset uncovers distinct interaction profiles for each variant, illustrating on how specific mutations can change viral protein functionality. Overall, our extensive analysis provides a detailed proteomic profile of host cell for each variant, offering valuable insights into how specific mutations may influence viral protein functionality and impact therapeutic target identification. These insights are crucial for the design of new targeted interventions, aiming to enhance the efficacy of treatments against evolving SARS-CoV-2 variants.
Mathematical Modeling and CFD Analysis with Experimental Investigation of the Geometry of the Grooves Created with CO2 Laser on the Polycarbonate Plate
Authors: Canel Timur , Baglan Irem , Karabas Ogan
Published: May 2024

Mathematical modeling of micro-scale grooves was made on the polycarbonate plate. The micro-scale groove's surface and cross-section structure, created by scanning at a constant speed using a 30 W beam with a CO2 laser, was examined with a high-resolution optical microscope and the groove geometry was precisely measured. Using the data obtained from the measurements and the physical constants of the polycarbonate, mathematical modeling was made for the temperature distribution in two different directions. The Fourier Finite difference method was used to model the temperature distribution along the line on the polycarbonate surface. The experimental studies with 5 different laser beam powers were carried out again to prove the accuracy and validity of the model. Lateral temperature distribution on the surface of the material and vertical temperature distribution towards the depths of the material were investigated separately. The error rates between the proposed mathematical model and the experimental results are between 3.24 % and 8.44 %. Since the experimental results are in good agreement with the proposed model, it can be said that the proposed mathematical model is a reliable model. Moreover, the temperature distributions both in the lateral direction and vertically into the material were modeled with CFD-Computational Fluid Dynamics. The sources of the differences between the ignition, melting and glass transition temperature obtained from the CFD analysis and the actual temperature values were discussed.
Cell-Free Adipose Tissue Extracts: A Novel Approach to Downregulate TRPV1 for Rosacea Treatment
Authors: Zhou Liuyi , Chen Lulu , Li Ting , Wang Lu , Zhao Ye , Fu Zexin , Wu Sufan , Jin Tingting
Published: May 2024

Rosacea is a chronic inflammatory skin disease that typically affects the central facial area. Its main clinical symptoms include paroxysmal flushing, telangiectasia, and non-temporary erythema. Cell-free adipose tissue extracts (ATEs) are liquid components extracted from human adipose tissue that contain large amounts of growth factors. Despite the scar-reducing, anti-aging, and wound-healing effects of ATEs, the efficacy of ATEs in rosacea remains unknown. Therefore, the anti-rosacea effects of ATEs were investigated in LL37 cathelicidin-induced rosacea mice and capsaicin (CAP)-stimulated HaCaT keratinocytes. The in vitro results revealed that ATEs alleviated rosacea symptoms, such as erythema score, erythema area, transepidermal water loss, epidermal thickness, and telangiectasia upon downregulating TRPV1 and CD31 expression. Moreover, the up-regulated TRPV1 protein expression was also recovered by ATEs administration in vivo and in vitro. Meanwhile, ATEs demonstrated good biocompatibility. In summary, ATEs could be a potential therapeutic agent for rosacea by regulating inflammation and alleviating telangiectasia.
Lack of knowledge and training about antibiotic resistance among community pharmacists in Bangladesh: a cross-sectional study
Authors: Hossain Md. Jubayer , Shahariar Musab , Barsha Lamia Hasan Joarder , Shahjahan Muhibullah , Towhid Syeda Tasneem , Sheikh Md. Kamrul , Hasan Md. Mehedi , Rahaman Md Habibur , Sazid Md Shahnewaz
Published: May 2024

This study aimed to assess the current level of knowledge and impact of training among community pharmacists in Bangladesh regarding antibiotic resistance, and to explore the potential relationship between knowledge, training, and antibiotic dispensing practices. A cross-sectional study was conducted among community pharmacists practicing in Bangladesh, using a self-administered questionnaire. The questionnaire assessed the respondents' demographic information, knowledge and attitude towards antibiotic use and antibiotic resistance, and practices towards improving appropriate antibiotic use in community pharmacies. The results of the study showed that the majority of community pharmacists in Bangladesh lacked knowledge and training regarding antibiotic resistance. Only 8.4% of the respondents had adequate knowledge of antibiotic resistance, and 38% had received training on the topic. Furthermore, a significant relationship was found between the level of knowledge and training received by community pharmacists and their antibiotic dispensing practices. Pharmacists with higher levels of knowledge and training were more likely to appropriately dispense antibiotics. The findings of this study highlight the need for increased education and training regarding antibiotic resistance among community pharmacists in Bangladesh. This is crucial for improving antibiotic dispensing practices and for reducing the spread of antibiotic resistance. Policymakers and educators should collaborate to develop and implement training programs and continuing education courses for community pharmacists to improve their knowledge and skills in this area.