bluuebunny/crossref_metadata_2025 huggingface dataset:
The implication of the increase in storm frequency and intensity to coastal housing markets
Authors: Kim Seung Kyum , Peiser Richard B.
Published: May 2020

This paper analyzes the effects of storm frequency and intensity on housing values in Miami‐Dade County over the last three decades. We found that higher storm exposure accelerates the housing price discount caused by augmented flood risk. The adverse effects of frequency and intensity have different impacts on perception of flood probabilities. Storm frequency affects housing prices in lower flood risk areas, whereas intensity influences the market in the higher risk zone, due to the different risk perceptions between the two factors. The results shed light on how increases in storm frequency and intensity impact the dynamics of flood risk perception in different floodplains on the coastal housing markets, suggesting future directions of flood prevention policies. Our findings highlight that one additional hurricane event is associated with a housing price discount of 1.3%. This adverse impact of frequency increases to 2.0% in the 500‐year floodplain zones, while higher storm intensity reduces housing values in the 100‐year floodplain zones by 1.5%.
The Leadership Mentoring in Nursing Research Program for Postdoctoral Nurses: A Development Paper
Authors: Hafsteinsdóttir Thóra B. , Schoonhoven Lisette , Hamers Jan , Schuurmans Marieke J.
Published: May 2020

Purpose

The Dutch Nursing Science Faculties developed the Leadership Mentoring in Nursing Research program, which aims to increase the cadre of nurse scientists, strengthen nursing research within universities, and improve the career development of postdoctoral nurses. The purpose of this article was to describe the development of the leadership and mentoring program to foster its replication and to present a formative program evaluation.

Design

The leadership mentoring program was developed using a three‐step procedure: a systematic review of the literature on successful leadership programs was conducted; theoretical underpinnings were identified and input; and feedback was solicited from national and international experts and changes made, resulting in the final program, which was executed from February 2016‐2018.

Findings

A 2‐year leadership and mentoring program for postdoctoral nurses working in research was developed and executed. Ten fellows completed the program and worked on their leadership development, developed their own research programs, and established research collaborations. Formative evaluations showed that the fellows highly valued the program sessions. We have learned several key lessons on how to structure, implement, and evaluate the leadership and mentoring program.

Conclusions

Through the leadership and mentoring program, the fellows are immersed in concerted leadership development focusing on the academic leadership role. Formative evaluations showed that the program was valued by the fellows and that several key lessons were learned.

Clinical Relevance

Through the leadership and mentoring program, 10 postdoctoral nurses strengthened their leadership in research and will further develop their role in healthcare research, clinical practice, and education.
Monoculture of ♀ channel (Ictalurus punctatus) × ♂ blue (I. furcatus) hybrid catfish mitigates proliferative gill disease caused by Henneguya ictaluri (Cnidaria: Myxobolidae) in catfish aquaculture ponds
Authors: Griffin Matt J. , Ware Cynthia , Rosser Thomas G. , Woodyard Ethan T. , Mischke Charles C. , Byars Todd S. , Wise David J.
Published: May 2020

Proliferative gill disease (PGD) caused by the myxozoan Henneguya ictaluri is one of the most damaging diseases affecting U.S. catfish aquaculture. In channel and hybrid catfish, continuous exposure to the actinospore stage of the parasite elicits a destructive branchitis, impairing osmoregulatory and respiratory function. Mortality can reach 100% in severe outbreaks. Despite similarities during acute stages of infection, research indicates arrested development in hybrid catfish, evinced by reduced H. ictaluri sporogenesis and comparably less parasite DNA in hybrid tissues across the developmental timeline. To assess these findings at the pond level, 18, 0.4‐ha ponds were stocked (3,000 fish/pond) with channel (n = 9) or hybrid (n = 9) catfish fingerlings and maintained as monoculture systems for three production cycles, with clean harvests and restocking as warranted. Water was collected monthly for quantitative polymerase chain reaction (qPCR) estimations of H. ictaluri DNA, and sentinel fish were utilized to estimate PGD severity. By the second year, H. ictaluri DNA in hybrid systems was significantly reduced, and PGD lesions in sentinel fish were negligible. Assessment of parasite loads in fish harvested at the termination of the study revealed H. ictaluri DNA in channel catfish to be an order of magnitude higher than hybrid catfish. These results support previous work suggesting that the production of hybrid catfish may reduce PGD incidence in U.S. catfish aquaculture.
Standardization for reliable uroflowmetry testing in adults
Authors: Ceyhan Erman , Asutay Mehmet K.
Published: May 2020

Objectives

To assess if a standard hydration protocol will achieve voided volumes over 150 mL and more reliable uroflowmetry results.

Methods

This is a single‐blinded crossover study of 40 patients with benign prostatic obstruction and 34 healthy volunteers. Subjects were enrolled prospectively between January and March 2019. All subjects performed two randomly ordered uroflowmetry tests. One test was performed when subjects sensed their bladder was full and had the urge to void and another one after emptying the bladder and ingesting 1.5 L of water within 1 hour (prehydration). Uroflowmetry parameters were compared between the benign prostatic obstruction group and the healthy volunteers. Uroflowmetry results were categorized as reliable, residual, and suboptimal with respect to voided volumes. This study has been registered in the UMIN Clinical Trials Registry (UMIN000035446).

Results

The benign prostatic obstruction group and the healthy volunteer group presented no difference in respect of uroflowmetry test reliability (P = .459). Uroflowmetry results were reliable in 58 (78.4%) subjects in the prehydrated group and was reliable in 30 (40.5%) subjects in the non‐prehydrated group. The difference was statistically significant (P < .05). In the benign prostatic obstruction group and healthy volunteer group, the rate of reliable uroflowmetry tests was significantly higher with prehydration (P < .05). The comparative analysis of uroflowmetry parameters between tests performed with and without prehydration revealed higher values in the prehydrated group (voided volume, maximum flow rate, average flow rate, and postvoiding residual volume; P < .05).

Conclusion

Prehydration of patients with 1.5 L of water within 1 hour before uroflowmetry improves uroflowmetry outcomes. By this hydration protocol, the chance to obtain a voided volume over 150 mL is increased significantly.
Integrative species delimitation reveals cryptic diversity in the southern Appalachian Antrodiaetus unicolor (Araneae: Antrodiaetidae) species complex
Authors: Newton Lacie G. , Starrett James , Hendrixson Brent E. , Derkarabetian Shahan , Bond Jason E.
Published: May 2020

Although species delimitation can be highly contentious, the development of reliable methods to accurately ascertain species boundaries is an imperative step in cataloguing and describing Earth's quickly disappearing biodiversity. Spider species delimitation remains largely based on morphological characters; however, many mygalomorph spider populations are morphologically indistinguishable from each other yet have considerable molecular divergence. The focus of our study, the Antrodiaetus unicolor species complex containing two sympatric species, exhibits this pattern of relative morphological stasis with considerable genetic divergence across its distribution. A past study using two molecular markers, COI and 28S, revealed that A. unicolor is paraphyletic with respect to A. microunicolor. To better investigate species boundaries in the complex, we implement the cohesion species concept and use multiple lines of evidence for testing genetic exchangeability and ecological interchangeability. Our integrative approach includes extensively sampling homologous loci across the genome using a RADseq approach (3RAD), assessing population structure across their geographic range using multiple genetic clustering analyses that include structure, principal components analysis and a recently developed unsupervised machine learning approach (Variational Autoencoder). We evaluate ecological similarity by using large‐scale ecological data for niche‐based distribution modelling. Based on our analyses, we conclude that this complex has at least one additional species as well as confirm species delimitations based on previous less comprehensive approaches. Our study demonstrates the efficacy of genomic‐scale data for recognizing cryptic species, suggesting that species delimitation with one data type, whether one mitochondrial gene or morphology, may underestimate true species diversity in morphologically homogenous taxa with low vagility.
When Asking “What” and “How” Helps You Win: Mimicry of Interrogative Terms Facilitates Successful Online Negotiations
Authors: Muir Kate , Joinson Adam , Collins Emily , Cotterill Rachel , Dewdney Nigel
Published: May 2020

Strategic word mimicry during negotiations facilitates better outcomes. We explore mimicry of specific word categories and perceptions of rapport, trust, and liking as underlying mechanisms. Dyads took part in an online negotiation exercise in which word mimicry was manipulated: Participants were instructed to mimic each other’s words (both‐mimic), one participant mimicked the other (half‐mimic), or neither participant mimicked (neither‐mimic). When given a simple instruction to mimic their partner, participants mimicked both the style (personal pronouns, adverbs, linguistic style, interrogative terms) and the content (affiliation terms, power terms, and assents) of their partner’s messages. Mimicry was associated with greater joint and individual points gain and perceptions of rapport from the mimicked partner. Further, mimicry of interrogative terms (e.g., how, why) mediated positive effects of mimicry upon negotiation outcomes, suggesting the coordination of question asking between negotiators is an important strategy to create beneficial interactions and add value in negotiations.
Localization shift of a sugar transporter contributes to phloem unloading in sweet watermelons
Authors: Ren Yi , Sun Honghe , Zong Mei , Guo Shaogui , Ren Zhijie , Zhao Jianyu , Li Maoying , Zhang Jie , Tian Shouwei , Wang Jinfang , Yu Yongtao , Gong Guoyi , Zhang Haiying , He Hongju , Li Legong , Zhang Xiaolan , Liu Fan , Fei Zhangjun , Xu Yong
Published: May 2020

Unloading sugar from sink phloem by transporters is complex and much remains to be understood about this phenomenon in the watermelon fruit.

Here, we report a novel vacuolar sugar transporter (ClVST1) identified through map‐based cloning and association study, whose expression in fruit phloem is associated with accumulation of sucrose (Suc) in watermelon fruit. ClVST197 knockout lines show decreased sugar content and total biomass, whereas overexpression of ClVST197 increases Suc content.

Population genomic and subcellular localization analyses strongly suggest a single‐base change at the coding region of ClVST197 as a major molecular event during watermelon domestication, which results in the truncation of 45 amino acids and shifts the localization of ClVST197 to plasma membranes in sweet watermelons. Molecular, biochemical and phenotypic analyses indicate that ClVST197 is a novel sugar transporter for Suc and glucose efflux and unloading.

Functional characterization of ClVST1 provides a novel strategy to increase sugar sink potency during watermelon domestication.
Proarrhythmic effects from competitive atrial pacing and potential programming solutions
Authors: Wass SoJin Y. , Kanj Mohamed , Mayuga Kenneth , Hussein Ayman , Saliba Walid I. , Bhargava Mandeep , Cantillon Daniel , Tchou Patrick J. , Wazni Oussama , Wilkoff Bruce L. , Chung Mina K.
Published: May 2020

Background

Programmed long AV delays and intrinsic long first degree AV block may increase risk for competitive atrial pacing (CAP) in devices without CAP avoidance algorithms.

Methods

Patients identified with CAP‐induced mode switch episodes were followed clinically from September 2013 to August 2019. Attempts to avoid CAP included shortening of postventricular atrial refractory period (PVARP) or postventricular atrial blanking period (PVAB), or change to AAI or DDI modes. After observing associations with sensor‐driven pacing, rate response was inactivated in a subset.

Results

Among 23 patients identified with CAP (22 St Jude Medical [Abbott]; one Boston Scientific Corporation devices), atrial fibrillation (AF) was induced in 12 (52%), lasting 10 seconds to 28 hours and 32 minutes. In one patient with an ICD CAP‐induced AF with rapid ventricular rates that triggered a shock, inducing ventricular fibrillation, syncope, and another shock. Changing AV delays and shortening of PVARP failed to resolve CAP. After noting that all had CAP during sensor‐driven pacing, rate response was inactivated in seven, resolving further device‐induced AF in the three of seven that had prior CAP‐induced AF. In two patients with intact AV conduction, AAI(R) pacing resolved further documentation of CAP.

Conclusions

CAP predominantly occurs during sensor‐driven atrial pacing that competes with intrinsic atrial events falling in PVARP. Inactivation of the activity sensor or change to atrial‐based pacing modes (AAI/R) appears to effectively prevent induction of device‐induced atrial proarrhythmia. Ultimately, a corrective algorithm is needed to avoid CAP‐induced proarrhythmia.
A retrospective cohort study of predictors and interventions that influence cooperation with mask induction in children
Authors: Marquez Juan L. , Wang Ellen , Rodriguez Samuel T. , O’Connell Chloe , Munshey Farrukh , Darling Curtis , Tsui Ban , Caruso Joseph , Caruso Thomas J.
Published: May 2020

Background

Uncooperative pediatric mask induction is linked to perioperative anxiety. Although some risk factors for uncooperative inductions have been reported, there are no large cohort studies that identify intrinsic patient characteristics associated with cooperation.

Aim

The primary aim was to identify patient characteristics associated with cooperative mask inductions. The secondary aim was to determine whether preoperative interventions were associated with increased cooperation.

Methods

This retrospective cohort study included patients 2‐11 years old and ASA class I‐IV who underwent mask induction. Our primary outcome of interest was cooperation with mask induction, which was correlated against the Induction Compliance Checklist. The variables analyzed for association with cooperation were age, sex, ASA class, class of surgery, preferred language, and race. Interventions examined for association with induction cooperation included premedication with midazolam, exposure to distraction technology, parental presence, and the presence of a Child Life Specialist. Multivariate mixed‐effects logistic regression was used to assess the relationship between patient characteristics and cooperation. A separate multivariate mixed‐effects logistic regression was used to examine the association between preoperative interventions and cooperation.

Results

9692 patients underwent 23 474 procedures during the study period. 3372 patients undergoing 5980 procedures met inclusion criteria. The only patient characteristic associated with increased cooperation was age (OR 1.20, p‐value 0.03). Involvement of Child Life Specialists was associated with increased cooperation (OR 4.44, p‐value = 0.048) while parental/guardian presence was associated with decreased cooperation (OR 0.38, p‐value = 0.002).

Conclusion

In this cohort, increasing age was the only patient characteristic found to be associated with increased cooperation with mask induction. Preoperative intervention by a Child Life Specialists was the sole intervention associated with improved cooperation.
Superior haplotypes for haplotype‐based breeding for drought tolerance in pigeonpea (Cajanus cajan L.)
Authors: Sinha Pallavi , Singh Vikas K. , Saxena Rachit K. , Khan Aamir W. , Abbai Ragavendran , Chitikineni Annapurna , Desai Aarthi , Molla Johiruddin , Upadhyaya Hari D. , Kumar Arvind , Varshney Rajeev K.
Published: May 2020

Haplotype‐based breeding, a recent promising breeding approach to develop tailor‐made crop varieties, deals with identification of superior haplotypes and their deployment in breeding programmes. In this context, whole genome re‐sequencing data of 292 genotypes from pigeonpea reference set were mined to identify the superior haplotypes for 10 drought‐responsive candidate genes. A total of 83, 132 and 60 haplotypes were identified in breeding lines, landraces and wild species, respectively. Candidate gene‐based association analysis of these 10 genes on a subset of 137 accessions of the pigeonpea reference set revealed 23 strong marker‐trait associations (MTAs) in five genes influencing seven drought‐responsive component traits. Haplo‐pheno analysis for the strongly associated genes resulted in the identification of most promising haplotypes for three genes regulating five component drought traits. The haplotype C. cajan_23080‐H2 for plant weight (PW), fresh weight (FW) and turgid weight (TW), the haplotype C. cajan_30211‐H6 for PW, FW, TW and dry weight (DW), the haplotype C. cajan_26230‐H11 for FW and DW and the haplotype C. cajan_26230‐H5 for relative water content (RWC) were identified as superior haplotypes under drought stress condition. Furthermore, 17 accessions containing superior haplotypes for three drought‐responsive genes were identified. The identified superior haplotypes and the accessions carrying these superior haplotypes will be very useful for deploying haplotype‐based breeding to develop next‐generation tailor‐made better drought‐responsive pigeonpea cultivars.
Endothelin signaling promotes melanoma tumorigenesis driven by constitutively active GNAQ
Authors: Jain Fagun , Longakit Anne , Huang Jenny Li‐Ying , Van Raamsdonk Catherine D.
Published: May 2020

The G‐protein‐coupled receptor, endothelin receptor B (EDNRB), is an important regulator of melanocyte survival and proliferation. It acts by stimulating downstream heterotrimeric G proteins, such as Gαq and Gα1. Constitutively active, oncogenic versions of Gαq and Gα11 drive melanomagenesis, but the role of Ednrb in the context of these mutant G proteins has not been previously examined. In this paper, we used a knock‐in mouse allele at the Rosa26 locus to force oncogenic GNAQQ209L expression in melanocytes in combination with Ednrb gene knockout. The resulting pathological analysis revealed that every aspect of melanomagenesis driven by GNAQQ209L was inhibited. We conclude that even in the presence of oncogenic Gαq, the Ednrb receptor activates normal Gαq and Gα11 proteins. This likely promotes tumorigenesis by activating phospholipase C‐beta, the immediate effector of Gαq/11. These findings suggest that it might be possible to target upstream receptors to offset the effects of hyperactive G proteins, recognized as the cause of a growing number of human disorders.
Australian Uromyces viciae‐fabae: Host and nonhost interaction among cultivated grain legumes
Authors: Ijaz Usman , Ayliffe Michael , Adhikari Kedar , Bariana Harbans , Bansal Urmil
Published: May 2020

Uromyces viciae‐fabae, rust of faba bean, parasitizes other legume crops such as lentils (Lens culinaris) and field peas (Pisum sativum) in some environments. In this study we examined the host range of two Australian isolates of U. viciae‐fabae collected and purified from a faba bean crop and classified as U. viciae‐fabae ex V. faba. Field pea (P. sativum), chickpea (Cicer arientinum), lupin (Lupinus spp.), lentil (L. culinaris), and mung bean (Vigna radiata) genotypes were tested with these isolates, as well as resistant and susceptible genotypes of the faba bean host. Race specificity for these two pathogen isolates was observed on Vicia faba, with two faba bean genotypes showing partial resistance. Both U. viciae‐fabae isolates also colonized field pea seedlings and successfully produced uredinia under glasshouse conditions, despite this fungus not being known as a pathogen of Australian field pea crops. No sporulation of either isolate of U. viciae‐fabae ex V. faba was observed on any of the remaining legume species tested. However, obvious differences in fungal growth were observed, ranging from small infection sites with very rare haustorium formation in mung bean to more extensive growth and the development of potential uredinial structures in chickpea. These observations are discussed in relation to the phylogenetic relationship of these host and nonhost species.
Characterization of thallus mechanical and physiological traits of tropical fucoids: A preliminary study
Authors: Sakanishi Yoshihiko , Tanaka Kouki , Kasai Hiromi , Tanaka Jiro
Published: May 2020

Thallus mechanical strength, as well as production of secondary metabolites as defensive compounds, of tropical macroalgae is often essential for protection from herbivory. In tropical macroalgae, thallus mechanical strength is negatively correlated with productivity — a trade‐off between productivity and thallus toughness. The tropical fucoids, Turbinaria ornata which has defensive morphological traits against herbivory and Sargassum ilicifolium which is expanding its distribution in Japanese waters, were examined to determine thallus traits related to mechanical strength and productivity and their pair‐wise relationships were also examined. These traits that are directly or indirectly related to the trade‐off between productivity and thallus toughness were compared to data for various other temperate macroalgae by regression analyses. We found two strong positive correlations between thallus mechanical strength and thallus mass or thallus thickness, confirming that higher levels of mechanical strength for tropical fucoids is associated with higher biomass or thallus thickness. Also, negative correlations between thallus toughness and productivity were found indicating structural and physiological trade‐offs. However, the tropical fucoids exhibited relatively high productivity regardless of their higher level of thallus toughness. These traits of the tropical fucoids slightly deviate from the typical conservative strategy with higher thallus toughness and lower productivity as a trade‐off between productivity and thallus toughness.
The anatomy of exhumed river‐channel belts: Bedform to belt‐scale river kinematics of the Ruby Ranch Member, Cretaceous Cedar Mountain Formation, Utah, USA
Authors: Cardenas Benjamin T. , Mohrig David , Goudge Timothy A. , Hughes Cory M. , Levy Joseph S. , Swanson Travis , Mason Jasmine , Zhao Feifei
Published: May 2020

Many published interpretations of ancient fluvial systems have relied on observations of extensive outcrops of thick successions. This paper, in contrast, demonstrates that a regional understanding of palaeoriver kinematics, depositional setting and sedimentation rates can be interpreted from local sedimentological measurements of bedform and barform strata. Dune and bar strata, channel planform geometry and bed topography are measured within exhumed fluvial strata exposed as ridges in the Ruby Ranch Member of the Cretaceous Cedar Mountain Formation, Utah, USA. The ridges are composed of lithified stacked channel belts, representing at least five or six re‐occupations of a single‐strand channel. Lateral sections reveal well‐preserved barforms constructed of subaqueous dune cross‐sets. The topography of palaeobarforms is preserved along the top surface of the outcrops. Comparisons of the channel‐belt centreline to local palaeotransport directions indicate that channel planform geometry was preserved through the re‐occupations, rather than being obscured by lateral migration. Rapid avulsions preserved the state of the active channel bed and its individual bars at the time of abandonment. Inferred minimum sedimentation durations for the preserved elements, inferred from cross‐set thickness distributions and assumed bedform migration rates, vary within a belt from one to ten days. Using only these local sedimentological measurements, the depositional setting is interpreted as a fluvial megafan, given the similarity in river kinematics. This paper provides a systematic methodology for the future synthesis of vertical and planview data, including the drone‐equipped 2020 Mars Rover mission, to exhumed fluvial and deltaic strata.
Environmental change and the informal plastic recycling networks of Kolkata
Authors: Schlitz Nicolas
Published: May 2020

This article introduces plastic recycling networks in Kolkata, India, as a case to illustrate the contradictory entanglement of economic and environmental change in urban informal contexts of the Global South. In light of the prevailing environmental critique of informal plastic recycling in India, this article discusses plastic recyclers’ environmental impact and contribution as well as the potential to enhance the environmental and economic performance of their business. Network and chain approaches in the emerging field of Environmental Economic Geography are combined with the notion of social metabolism to conceptualize the entanglement of environmental and economic processes as well as socio‐environmental inequalities entailed in recycling networks. The analysis reveals the impact that the heterogeneity and fluctuation of plastic waste supply has on the economic organization of recycling networks, giving rise to distinct forms of governance in its intermediate and down‐stream segments. Such an integrated perspective also serves to explain why environmental upgrading is hard to achieve under prevailing circumstances by plastic recyclers in Kolkata. Based on an assessment of the social and political conditions of informality under which plastic recyclers operate, the adoption of common assumptions about ecological modernization imbuing parts of Environmental Economic Geography is called into question.
Multilingualism in the linguistic landscape of Istanbul
Authors: İnal Dilek , Bayyurt Yasemin , Özturhan Münir , Bektaş Sezen
Published: May 2020

Situated in the Expanding Circle, Turkey has become a setting which offers vibrant linguistic landscapes fascinating to linguists. Underlying this vibrancy is the prevalent use of English for a wide variety of instrumental purposes and multilingualism that is becoming increasingly tangible. This paper explores how diversity brought about by globalization and migration has generated an interesting mix of languages, scripts and modalities led by English in the Turkish context. The data collected from the streets of various districts in Istanbul indicate an interplay of Turkish, English and Arabic, and a sociolinguistic analysis reveals practices of code‐switching and translanguaging. The pedagogical implications highlight the importance of promoting a WE/ELF‐aware English language teaching through a framework that considers both the plurilingual view of English and the entailing sociolinguistic processes.
Most Valued Experiences in an International Coach Developer Training Programme
Authors: Campbell Sara M. , Fallaize Ashley , Schempp Paul
Published: May 2020

Coach developers provide education and support to coaches. Therefore, these individuals play an important role in coaching systems. However, the formal training of coach developers is a relatively new concept. Both practitioners and academics seem eager to understand how to effectively train these individuals. We had the opportunity to collect feedback from participants of an international coach developer training programme (CDTP). The primary purpose of this insights paper is to share this feedback and make recommendations for future CDTPs based on connections between participant feedback and relevant literature. A secondary purpose of this paper is to stimulate dialogue from programme participants and coordinators, who can offer additional insight regarding their experiences in CDTPs.
Myeloma cells shift osteoblastogenesis to adipogenesis by inhibiting the ubiquitin ligase MURF1 in mesenchymal stem cells
Authors: Liu Zhiqiang , Liu Huan , He Jin , Lin Pei , Tong Qiang , Yang Jing
Published: May 2020

Myeloma cells repress osteoblastogenesis by inhibiting the degradation of PPARγ2 in mesenchymal stem cells.
Protection between tissues and across species
Authors: Wong Wei
Published: May 2020

Lactobacilli
in the gut stimulate Nrf2-dependent antioxidant responses in the liver.
Complete Genome Sequence of Human Oral Phylogroup 1
Treponema
sp. Strain OMZ 804 (ATCC 700766), Originally Isolated from Periodontitis Dental Plaque
Authors: Chan Yuki , Huo Yong-Biao , Yu Xiaolin , Zeng Huihui , Leung Wai Keung , Watt Rory M.
Published: May 2020

Host-associated treponeme bacteria play etiological roles in human and animal soft tissue infections.
Treponema
sp. strain OMZ 804 (ATCC 700766) was isolated from dental plaque sampled from a patient with periodontitis in Switzerland in 1994. We report here the complete genome sequence of its 2.98-Mb circular chromosome.
Horizontal Gene Transfer of Antibiotic Resistance from Acinetobacter baylyi to Escherichia coli on Lettuce and Subsequent Antibiotic Resistance Transmission to the Gut Microbiome
Authors: Maeusli Marlène , Lee Bosul , Miller Sarah , Reyna Zeferino , Lu Peggy , Yan Jun , Ulhaq Amber , Skandalis Nicholas , Spellberg Brad , Luna Brian
Published: May 2020

Previous efforts have correlated antibiotic-fed livestock and meat products with respective antibiotic resistance genes, but virtually no research has been conducted on the transmission of antibiotic resistance from plant foods to the mammalian gut (C. S. Hölzel, J. L. Tetens, and K. Schwaiger, Pathog Dis 15:671–688, 2018,
https://doi.org/10.1089/fpd.2018.2501
; C. M. Liu et al., mBio 9:e00470-19, 2018,
https://doi.org/10.1128/mBio.00470-18
; B. Spellberg et al., NAM Perspectives, 2016,
https://doi.org/10.31478/201606d
; J. O’Neill, Antimicrobials in agriculture and the environment, 2015; Centers for Disease Control and Prevention, Antibiotic resistance threats in the United States, 2019). Here, we sought to determine if horizontal transmission of antibiotic resistance genes can occur between lettuce and the mammalian gut microbiome, using a mouse model. Furthermore, we have created a new model to study horizontal gene transfer on lettuce leaves using an antibiotic-resistant transformant of
A. baylyi
(Ab
zeoR
).
Structuring a UK military role 1 medical treatment facility for a sustained mobile exercise in a hot desert environment: UK military exercise SAIF SAREEA 3
Authors: Hain Jennifer , Smith M B
Published: May 2020

Exercise SAIF SAREEA 3 (SS3) is a triservice combined joint training military Exercise between the UK and the Omani Armed forces. SS3 represented a rare opportunity to exercise a complete role 1 medical reception station (MRS) in a tented platform for a prolonged period providing ‘real life support’, as opposed to an exercise without casualties. This article is a discursive paper making recommendations for amendments to the established structure for the MRS within static high-temperature deployments. Considering the facility blueprint, recognising and implementing improvements to patient flow and increasing infection prevention control measures resulted in limiting the spread of disease outbreak. During the deployment there were considerable challenges delivering care in extreme heat above 50°C these included the use of environmental control units, white liners and refrigerator units which allowed care to be delivered throughout the day, and for the appropriate care of both casualties and medication. Finally, the article covers improved patient service with a paper-based triage system supporting innovative ideas to deliver care.
Enhanced B7-H4 expression in gliomas with low PD-L1 expression identifies super-cold tumors
Authors: Chen Di , Li Gaopeng , Ji Chunxia , Lu Qiqi , Qi Ying , Tang Chao , Xiong Ji , Hu Jian , Yasar Fatma Betul Aksoy , Zhang Yan , Hoon Dave S B , Yao Yu , Zhou Liangfu
Published: May 2020

Background

Characterizing expression profiles of different immune checkpoint molecules are promising for personalized checkpoint inhibitory immunotherapy. Gliomas have been shown as potential targets for immune checkpoint inhibitors recently. Our study was performed to determine coexpression levels of two major B7 immune regulatory molecules programmed death ligand 1 (PD-L1) and B7-H4, both of which have been demonstrated to inhibit antitumor host immunity in gliomas.

Methods

We assessed tumor tissues from stage II–IV primary gliomas (n=505) by immunohistochemistry (IHC) for protein levels of both PD-L1 and B7-H4. Gene coexpression analysis assessing clusters based on extent of PD-L1/B7-H4 classifier genes expression were investigated in two transcriptome datasets (The Cancer Genome Atlas and Chinese Glioma Genome Atlas). In addition, levels of immune cell infiltrates were estimated with IHC and RNA-seq data for assessing the tumor immune microenvironment of PD-L1/B7-H4 subgroups.

Results

High expression of PD-L1 and B7-H4 in gliomas was 23% and 20%, respectively, whereas coexpression of two proteins at high levels was limited to 2% of the cases. Comparable results were seen in RNA-seq datasets where PD-L1 mRNA expression levels negatively correlated with that of B7-H4. Gene coexpression modules clustered within each grade of gliomas demonstrated lack of double-high modules (cluster with high expression of both PD-L1 and B7-H4 classifier genes). B7-H4 mRNA expression levels showed negative correlation with extent of immune cell infiltration and High-B7-H4 module gliomas (high B7-H4 but low PD-L1 classifier genes expression) had less tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). IHC assessment also showed few TILs and TAMs in High-B7-H4 subgroup gliomas.

Conclusions

The majority of gliomas express PD-L1 or B7-H4, however, coexpression of both at high levels is minimal. The high-B7-H4 patients could be considered as ‘super-cold’ gliomas with significantly deficient in TILs, suggesting that B7-H4 might inhibit T-cell trafficking into the central nervous system. This study demonstrated that PD-L1 and B7-H4 may serve as mutually compensatory immune checkpoint molecules in gliomas for immune targeted or active-specific immunotherapy. The distinct B7-H4 pathways modulating T-cell function and immune evasion in glioma patients deserved to be further explored in the future during immunotherapy.
Effects of two-year weather exposure on thermally modifiedPicea abies,Pinus sylvestris, andFraxinus excelsiorwood
Authors: Cai Chenyang , Haapala Antti , Rahman Mohammad Habibur , Tiitta Markku , Tiitta Valtteri , Tomppo Laura , Lappalainen Reijo , Heräjärvi Henrik
Published: May 2020

The use of thermally modified timber (TMT) in outdoor applications is well established, but its performance against the stresses of outdoor conditions is not comprehensively understood. This study investigates the changes in density, surface chemical composition, color, equilibrium moisture content (EMC), checking, hardness, and cupping of thermally modified boards of Scots pine (Pinus sylvestris L.), Norway spruce (Picea abies (L.) H. Karst.), and European ash (Fraxinus excelsior L.) during a two-year weather exposure test in Eastern Finland. Unmodified pine, spruce, and ash and copper salt impregnated pine boards were used as controls. The results show that a two-year weather exposure period causes degradation of hydrophobic lignin, and the leaching of the degraded compounds changed the color, increased the EMC, and decreased the hardness of specimens. Although the EMC of TMT specimens was lower compared with unmodified and impregnated ones during weathering, the changes were more obvious in TMT than in the controls. More checks occurred in the TMT specimens than in unmodified ones after the exposure. On the other hand, the TMT specimens had a lower degree of cupping. These findings also indicate that an increase in modification temperature induces more checks but improves the durability of all studied species by reducing the chemical degradation, color change, cupping, and hygroscopicity during weather exposure.
Kerr-AdS black hole behaviors from dark energy
Authors: Belhaj A. , El Balali A. , El Hadri W. , Essebani M. A. , Sedra M. B. , Segui A.
Published: May 2020

We investigate the critical behaviors of four-dimensional Kerr-AdS black holes from quintessential Dark Energy (DE) contributions. Using a moduli space, coordinated by the DE state parameter [Formula: see text] and the quintessence field intensity [Formula: see text], we deal with three different [Formula: see text]-models. By elaborating analytical formulas of relevant thermodynamical quantities denoted by [Formula: see text], we find significant similarities and distinctions. Precisely, for the [Formula: see text]-model, we show that DE contributions stabilize such black holes. For the [Formula: see text]-model, however, we get a reversed DE effect. In the [Formula: see text]-model, Kerr-AdS black holes reveal a resistance regarding the usual DE effects. Exploiting the explicit formulas of such thermodynamical quantities, we give certain physical interpretations for thermal behaviors. Although such relevant distinctions, we show that the [Formula: see text]-models involve similar universal ratios associated with certain critical thermodynamical quantities. Then, we analyze the photon orbits in the presence of DE.
Rectified deep neural networks overcome the curse of dimensionality for nonsmooth value functions in zero-sum games of nonlinear stiff systems
Authors: Reisinger Christoph , Zhang Yufei
Published: May 2020

In this paper, we establish that for a wide class of controlled stochastic differential equations (SDEs) with stiff coefficients, the value functions of corresponding zero-sum games can be represented by a deep artificial neural network (DNN), whose complexity grows at most polynomially in both the dimension of the state equation and the reciprocal of the required accuracy. Such nonlinear stiff systems may arise, for example, from Galerkin approximations of controlled stochastic partial differential equations (SPDEs), or controlled PDEs with uncertain initial conditions and source terms. This implies that DNNs can break the curse of dimensionality in numerical approximations and optimal control of PDEs and SPDEs. The main ingredient of our proof is to construct a suitable discrete-time system to effectively approximate the evolution of the underlying stochastic dynamics. Similar ideas can also be applied to obtain expression rates of DNNs for value functions induced by stiff systems with regime switching coefficients and driven by general Lévy noise.
Story mapping and sea level rise
Authors: Stephens Sonia H. , Richards Daniel P.
Published: May 2020

While interactive maps are important tools for risk communication, most maps omit the lived experiences and personal stories of the community members who are most at risk. We describe a project to develop an interactive tool that juxtaposes coastal residents' videorecorded stories about sea level rise and coastal flooding with an interactive map that shows future sea level rise projections. We outline project development including digital platform selection, project design, participant recruitment, and narrative framing, and tie our design decisions to rhetorical and ethical considerations of interest for others developing interactive tools with community participation.
CoFi-points
Authors: Li Lin , Pan Weike , Ming Zhong
Published: May 2020

With the explosive growth of web resources, an increasingly important task in recommender systems is to provide high-quality personalized services by learning users’ preferences from historically observed information. As an effective preference learning technology, collaborative filtering has been widely extended to model the one-class or implicit feedback data, which is known as one-class collaborative filtering (OCCF). For a long time, pairwise ranking-oriented learning scheme has been viewed as a superior solution than the pointwise scheme for OCCF due to its higher accuracy in most cases. However, we argue that with appropriate model design, pointwise preference learning can achieve comparable or even better performance than the counterpart, i.e., pairwise preference learning. In particular, we propose a new preference assumption, i.e., pointwise preference on user/item-set. Based on this new assumption, we develop a novel, simple, and flexible solution called collaborative filtering via pointwise preference learning on user/item-set (CoFi-points). Furthermore, we derive two specific algorithms of CoFi-points with respect to the involved user-set and item-set, i.e., CoFi-points(u) and CoFi-points(i), referring to preference assumptions defined on user-set and item-set, respectively. Finally, we conduct extensive empirical studies on four real-world datasets with the state-of-the-art methods, and find that our solution can achieve very promising performance with respect to several ranking-oriented evaluation metrics.
A Prospect Theoretic Approach for Trust Management in IoT Networks Under Manipulation Attacks
Authors: Salimitari Mehrdad , Bhattacharjee Shameek , Chatterjee Mainak , Fallah Yaser P.
Published: May 2020

As Internet of Things (IoT) and Cyber-Physical systems become more ubiquitous in our daily lives, it necessitates the capability to measure the trustworthiness of the aggregate data from such systems to make fair decisions. However, the interpretation of trustworthiness is contextual and varies according to the risk tolerance attitude of the concerned application. In addition, there exist varying levels of uncertainty associated with an evidence upon which a trust model is built. Hence, the data integrity scoring mechanisms require some provisions to adapt to different risk attitudes and uncertainties.

In this article, we propose a prospect theoretic framework for data integrity scoring that quantifies the trustworthiness of the collected data from IoT devices in the presence of adversaries who try to manipulate the data. In our proposed method, we consider an imperfect anomaly monitoring mechanism that tracks the transmitted data from each device and classifies the outcome (trustworthiness of data) as
not compromised, compromised,
or
undecided
. These outcomes are conceptualized as a multinomial hypothesis of a Bayesian inference model with three parameters. These parameters are then used for calculating a utility value via prospect theory to evaluate the reliability of the aggregate data at an IoT hub. In addition, to take into account different risk attitudes, we propose two types of fusion rule at IoT hub—optimistic and conservative.

Furthermore, we put forward asymmetric weighted moving average scheme to measure the trustworthiness of aggregate data in presence of On-Off attacks. The proposed framework is validated using extensive simulation experiments for both uniform and On-Off attacks. We show how trust scores vary under a variety of system factors like attack magnitude and inaccurate detection. In addition, we measure the trustworthiness of the aggregate data using the well-known expected utility theory and compare the results with that obtained by prospect theory. The simulation results reveal that prospect theory quantifies trustworthiness of the aggregate data better than expected utility theory.
Power to the People
Authors: Frazelle Jessie
Published: May 2020

By designing rack-level architectures, huge improvements can be made for power efficiency over conventional servers, since PSUs will be less oversized, more consolidated, and redundant for the rack versus per server. While the hyperscalers have benefited from these gains in power efficiency, most of the industry is still waiting. The Open Compute Project was started as an effort to allow other companies running datacenters to benefit from the power efficiencies as well. If more organizations run rack-scale architectures in their datacenters, the wasted carbon emissions caused by conventional servers can be lessened.
Influence of Fluid Viscous Damper on the Dynamic Response of Suspension Bridge under Random Traffic Load
Authors: Zhao Yue , Huang Pingming , Long Guanxu , Yuan Yangguang , Sun Yamin
Published: May 2020

Fluid viscous dampers (FVDs) are widely used in long‐span suspension bridges for earthquake resistance. To analyze efficiently the influences of FVDs on the dynamic response of a suspension bridge under high‐intensity traffic flow, a bridge‐vehicle coupling method optimized by isoparametric mapping and improved binary search in this work was first developed and validated. Afterwards, the traffic flow was simulated on the basis of monitored weigh‐in‐motion data. The dynamic responses of bridge were analyzed by the proposed method under different FVD parameters. Results showed that FVDs could positively affect bridge dynamic response under traffic flow. The maximum accumulative longitudinal girder displacement, longitudinal girder displacement, and longitudinal pylon acceleration decreased substantially, whereas the midspan girder bending moment, pylon bending moment, longitudinal pylon displacement, and suspender force were less affected. The control efficiency of maximum longitudinal girder displacement and accumulative girder displacement reached 33.67% and 57.71%, longitudinal pylon acceleration and girder bending moment reached 31.51% and 7.14%, and the pylon longitudinal displacement, pylon bending moment, and suspender force were less than 3%. The increased damping coefficient and decreased velocity exponent can reduce the bridge dynamic response. However, when the velocity exponent was 0.1, an excessive damping coefficient brought little improvement and may lead to high‐intensity work under traffic flow, which will adversely affect component durability. The benefits of low velocity exponent also reduced when the damping coefficient was high enough, so if the velocity exponent has to be increased, the damping coefficient can be enlarged to fit with the velocity exponent. The installation of FVDs influences dynamic responses of bridge structures in daily operations and this issue warrants investigation. Thus, traffic load should be considered in FVD design because structural responses are perceptibly influenced by FVD parameters.