bluuebunny/crossref_metadata_2025 huggingface dataset:
Sociological Profiling of Armed Robbery Convicts in Kirikiri Female Prisons, Lagos, Nigeria
Authors: Aborisade Richard Abayomi , Oni Similade Fortune
Published: October 2020

Increasing female involvement in violent crime is a concern in Nigeria; still, it is unclear what informs this sudden surge in a society that supposedly socializes feminine gender to be soft, caring, and compassionate. This article explores the sociological profiles of women involved in armed robbery, drawing case examples from 32 convicts in a Nigerian female penitentiary. It was found that women were made susceptible to deviance by some social factors such as familial variables, neighborhood characteristics, gender discrimination, neglect, and violence. Both primary and secondary social groups were found to be major facilitators in the initiation into crime, development of criminal career, entry into armed robbery, and maintenance of life as a robber. This article concludes that gender-based inequality in all social facets and the unfavorable socio-economic conditions in Nigeria increase the vulnerability of women to be recruited into criminality. A revival of the family institution, gender-neutral parenting, government’s intervention for improvement of socio-economic wellbeing, and gender education are suggested.
Effects of Hurricanes on Emergency Department Utilization: An Analysis Across 7 US Storms
Authors: Heslin Kevin C , Barrett Marguerite L , Hensche Molly , Pickens Gary , Ringel Jeanne S , Karaca Zeynal , Owens Pamela L
Published: October 2020

Objective:

Emergency departments (EDs) are critical sources of care after natural disasters such as hurricanes. Understanding the impact on ED utilization by subpopulation and proximity to the hurricane’s path can inform emergency preparedness planning. This study examines changes in ED utilization for residents of 344 counties after the occurrence of 7 US hurricanes between 2005 and 2016.

Methods:

This retrospective observational study used ED data from the Healthcare Cost and Utilization Project State Inpatient Databases and State Emergency Department Databases. ED utilization rates for weeks during and after hurricanes were compared with pre-hurricane rates, stratified by the proximity of the patient county to the hurricane path, age, and disease category.

Results:

The overall population rate of weekly ED visits changed little post-hurricane, but rates by disease categories and age demonstrated varying results. Utilization rates for respiratory disorders exhibited the largest post-hurricane increase, particularly 2–3 weeks following the hurricane. The change in population rates by disease categories and age tended to be larger for people residing in counties closer to the hurricane path.

Conclusions:

Changes in ED utilization following hurricanes depend on disease categories, age, and proximity to the hurricane path. Emergency managers could incorporate these factors into their planning processes.
On the rotation sets of generic homeomorphisms on the torus
Authors: LIMA HEIDES , VARANDAS PAULO
Published: October 2020

We study the rotation sets for homeomorphisms homotopic to the identity on the torus

$\mathbb T^d$
,

$d\ge 2$
. In the conservative setting, we prove that there exists a Baire residual subset of the set

$\text {Homeo}_{0, \lambda }(\mathbb T^2)$
of conservative homeomorphisms homotopic to the identity so that the set of points with wild pointwise rotation set is a Baire residual subset in

$\mathbb T^2$
, and that it carries full topological pressure and full metric mean dimension. Moreover, we prove that for every

$d\ge 2$
the rotation set of

$C^0$
-generic conservative homeomorphisms on

$\mathbb T^d$
is convex. Related results are obtained in the case of dissipative homeomorphisms on tori. The previous results rely on the description of the topological complexity of the set of points with wild historic behavior and on the denseness of periodic measures for continuous maps with the gluing orbit property.
Assessing severe acute respiratory coronavirus virus 2 (SARS-CoV-2) preparedness in US community hospitals: A forgotten entity
Authors: Advani Sonali D. , Baker Esther , Cromer Andrea , Wood Brittain , Crawford Kathryn L. , Crane Linda , Adcock Linda , Roach Linda , Padgette Polly , Anderson Deverick J. , Sexton Daniel J. ,   for the CDC Prevention Epicenter Program
Published: October 2020

We performed a cross-sectional survey of infection preventionists in 60 US community hospitals between April 22 and May 8, 2020. Several differences in hospital preparedness for SARS-CoV-2 emerged with respect to personal protective equipment conservation strategies, protocols related to testing, universal masking, and restarting elective procedures.
Increase in surgical site infections caused by gram-negative bacteria in warmer temperatures: Results from a retrospective observational study
Authors: Aghdassi Seven Johannes Sam , Gastmeier Petra , Hoffmann Peter , Schwab Frank
Published: October 2020

Objective:

Surgical site infections (SSIs) occur more frequently during periods of warmer temperatures. We aimed to investigate for which pathogens this association is particularly strong.

Design:

A retrospective observational study was conducted.

Methods:

Data from the SSI-module of the German nosocomial infection surveillance system between 2000 and 2016 were linked with data from the German Meteorological Service. Patient- and procedure-related data were associated with monthly aggregated meteorological data. Due to high correlation with other meteorological parameters, we focused on the outside temperature. Adjusted odds ratios were calculated for SSI rates relating to temperature. SSIs were stratified by pathogen. A P value of <.05 was considered significant.

Results:

Altogether, 2,004,793 procedures resulting in 32,118 SSIs were included. Generally, warmer temperatures were associated with a higher SSI risk, especially for SSIs with gram-negative pathogens. This association was particularly prominent for Acinetobacter spp, Pseudomonas aeruginosa, and certain Enterobacteriaceae. Per additional 1°C, we observed a 6% increase in the SSI risk for Acinetobacter spp and a 4% increase for Enterobacter spp. Superficial SSIs with Acinetobacter spp were 10 times more likely to occur when comparing surgeries in months with mean temperatures of ≥20°C to mean temperatures of <5°C.

Conclusions:

Higher temperatures were associated with increased SSI rates caused by gram-negative bacteria. Future SSI prevention measures should consider this aspect. Underlying shifts in microbiome composition due to climate factors should be included in further analyses. Given the expected rise of global temperatures until the end of the century, this topic has relevance from multiple perspectives.
David Hume in Chicago: A Twentieth-Century Hoax
Authors: Waldmann Felix
Published: October 2020

This article alleges that two letters attributed to the philosopher David Hume (1711–1776) were forged in the twentieth century. The letters were first published in 1972 and 1973 by Michael Morrisroe, an assistant professor of English in the University of Illinois, Chicago Circle, after which they became monuments of conventional scholarship on Hume's life and writings. Both letters are cited without qualification by scholars of Hume's thought in dozens of publications, including Ernest Campbell Mossner's celebratedLife of David Hume(1980), and John Robertson's entry for Hume in theOxford Dictionary of National Biography(2004). This article reconstructs the history and transmission of Hume's extant letters and attempts to account for why the forgeries published by Morrisroe were accepted as genuine. It makes a systematic case against the authenticity of the letters, and focuses in particular on the question of whether Hume met the Jansenisthomme de lettresNoël-Antoine Pluche (1688–1761) and had access to his library, in Reims, in 1734. The article concludes with a discussion of the implications of the exposé for modern editorial scholarship and intellectual history.
Updated inventory of glacier ice in New Zealand based on 2016 satellite imagery
Authors: Baumann Sabine , Anderson Brian , Chinn Trevor , Mackintosh Andrew , Collier Catherine , Lorrey Andrew M. , Rack Wolfgang , Purdie Heather , Eaves Shaun
Published: October 2020

The only complete inventory of New Zealand glaciers was based on aerial photography starting in 1978. While there have been partial updates using 2002 and 2009 satellite data, most glaciers are still represented by the 1978 outlines in contemporary global glacier databases. The objective of this project is to establish an updated glacier inventory for New Zealand. We have used Landsat 8 OLI satellite imagery from February and March 2016 for delineating clean glaciers using a semi-automatic band ratio method and debris-covered glaciers using a maximum likelihood classification. The outlines have been checked against Sentinel-2 MSI data, which have a higher resolution. Manual post processing was necessary due to misclassifications (e.g. lakes, clouds), mapping in shadowed areas, and combining the clean and debris-covered parts into single glaciers. New Zealand glaciers cover an area of 794 ± 34 km2 in 2016 with a debris-covered area of 10%. Of the 2918 glaciers, seven glaciers are >10 km2 while 71% is <0.1 km2. The debris cover on those largest glaciers is >40%. Only 15 glaciers are located on the North Island. For a selection of glaciers, we were able to calculate the area reduction between the 1978 and 2016 inventories.
Snow wetness retrieved from close-range L-band radiometry in the western Greenland ablation zone
Authors: Naderpour Reza , Houtz Derek , Schwank Mike
Published: October 2020

Close-range (CR) L-band radiometry and quasi-simultaneous in situ snow characterizations were conducted in May 2019 at the Swiss Camp research site in the ablation zone of the western Greenland ice sheet. Snow liquid-water and its melt/refreeze are retrieved from microwave antenna temperatures measured with the ground-based L-band radiometer ELBARA-III. The emission model (EM) used in the retrieval is a two-layer configuration of the ‘L-Band Specific Microwave Emission Model of Layered Snowpack’. Consistent snow wetness retrievals were achieved from both single- and multi-angle CR observations of L-band antenna temperatures. This suggests that multi-angle observation is not a pre-requisite for snow wetness retrieval. Therefore, in addition to soil moisture and ocean salinity (SMOS) multi-angle measurements, snow wetness can be estimated from spaceborne L-band brightness temperatures measured at a single observation angle, such as from NASA's SMAP satellite. Our results provide partial validation of a recently presented snow wetness retrieval approach based on the same EM and applied over Greenland using multi-angle SMOS brightness temperatures. Agreement between measured CR antenna temperatures and SMOS brightness temperatures is found to be within the 95% confidence intervals of ELBARA-III and SMOS measurement uncertainties. Our measurements confirm the modeled response of antenna temperatures to diurnal variations of snow wetness.
A GENERALIZATION OF THE THEORY OF STANDARDLY STRATIFIED ALGEBRAS I: STANDARDLY STRATIFIED RINGOIDS
Authors: MENDOZA O. , ORTÍZ M. , SÁENZ C. , SANTIAGO V.
Published: October 2020

We extend the classical notion of standardly stratified k-algebra (stated for finite dimensional k-algebras) to the more general class of rings, possibly without 1, with enough idempotents. We show that many of the fundamental results, which are known for classical standardly stratified algebras, can be generalized to this context. Furthermore, new classes of rings appear as: ideally standardly stratified and ideally quasi-hereditary. In the classical theory, it is known that quasi-hereditary and ideally quasi-hereditary algebras are equivalent notions, but in our general setting, this is no longer true. To develop the theory, we use the well-known connection between rings with enough idempotents and skeletally small categories (ringoids or rings with several objects).
Does smoking cause lower educational attainment and general cognitive ability? Triangulation of causal evidence using multiple study designs
Authors: Gage Suzanne H. , Sallis Hannah M. , Lassi Glenda , Wootton Robyn E. , Mokrysz Claire , Davey Smith George , Munafò Marcus R.
Published: October 2020

Background

Observational studies have found associations between smoking and both poorer cognitive ability and lower educational attainment; however, evaluating causality is challenging. We used two complementary methods to explore this.

Methods

We conducted observational analyses of up to 12 004 participants in a cohort study (Study One) and Mendelian randomisation (MR) analyses using summary and cohort data (Study Two). Outcome measures were cognitive ability at age 15 and educational attainment at age 16 (Study One), and educational attainment and fluid intelligence (Study Two).

Results

Study One: heaviness of smoking at age 15 was associated with lower cognitive ability at age 15 and lower educational attainment at age 16. Adjustment for potential confounders partially attenuated findings (e.g. fully adjusted cognitive ability β −0.736, 95% CI −1.238 to −0.233, p = 0.004; fully adjusted educational attainment β −1.254, 95% CI −1.597 to −0.911, p < 0.001). Study Two: MR indicated that both smoking initiation and lifetime smoking predict lower educational attainment (e.g. smoking initiation to educational attainment inverse-variance weighted MR β −0.197, 95% CI −0.223 to −0.171, p = 1.78 × 10−49). Educational attainment results were robust to sensitivity analyses, while analyses of general cognitive ability were less so.

Conclusion

We find some evidence of a causal effect of smoking on lower educational attainment, but not cognitive ability. Triangulation of evidence across observational and MR methods is a strength, but the genetic variants associated with smoking initiation may be pleiotropic, suggesting caution in interpreting these results. The nature of this pleiotropy warrants further study.
The use of multiple hypothesis-generating methods in an outbreak investigation of Escherichia coli O121 infections associated with wheat flour, Canada 2016–2017
Authors: Morton V. , Kershaw T. , Kearney A. , Taylor M. , Galanis E. , Mah V. , Adhikari B. , Whitfield Y. , Duchesne C. , Hoang L. , Chui L. , Grant K. , Hexemer A.
Published: October 2020

A Canadian outbreak investigation into a cluster of Escherichia coli O121 was initiated in late 2016. When initial interviews using a closed-ended hypothesis-generating questionnaire did not point to a common source, cases were centrally re-interviewed using an open-ended approach. The open-ended interviews led cases to describe exposures with greater specificity, as well as food preparation activities. Data collected supported hypothesis generation, particularly with respect to flour exposures. In March 2017, an open sample of Brand X flour from a case home, and a closed sample collected at retail of the same brand and production date, tested positive for the outbreak strain of E. coli O121. In total, 76% (16/21) of cases reported that they used or probably used Brand X flour or that it was used or probably was used in the home during their exposure period. Crucial hypothesis-generating techniques used during the course of the investigation included a centralised open-ended interviewing approach and product sampling from case homes. This was the first outbreak investigation in Canada to identify flour as the source of infection.
SARS-CoV-2 transmission: a sociological review
Authors: Siff Emily J. , Aghagoli Ghazal , Gallo Marin Benjamin , Tobin-Tyler Elizabeth , Poitevien Patricia
Published: October 2020

The current pandemic is defined by the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that can lead to coronavirus disease 2019 (COVID-19). How is SARS-CoV-2 transmitted? In this review, we use a global lens to examine the sociological contexts that are potentially and systematically involved in high rates of SARS-CoV-2 transmission, including lack of personal protective equipment, population density and confinement. Altogether, this review provides an in-depth conspectus of the current literature regarding how SARS-CoV-2 disproportionately impacts many minority communities. By contextualising and disambiguating transmission risks that are particularly prominent for disadvantaged populations, this review can assist public health efforts throughout and beyond the COVID-19 pandemic.
Emotion regulation deficits mediate childhood sexual abuse effects on stress sensitization and depression outcomes
Authors: Yaroslavsky Ilya , Bush Angela H. , France Christopher M.
Published: October 2020

Child sexual abuse (CSA) is a notable risk factor for depressive disorders. Though multiply determined, increased sensitivity to stress (stress sensitization) and difficulty managing distress (emotion regulation) may reflect two pathways by which CSA confers depression risk. However, it remains unclear whether stress sensitization and emotion regulation deficits contribute to depression risk independently or in a sequential manner. That is, the frequent use of maladaptive emotion regulation responses and insufficient use of those that attenuate distress (adaptive emotion regulation) may lead to stress sensitization. We tested competing models of CSA, stress sensitization, and emotion regulation to predict depression symptoms and depressive affects in daily life among adults with and without histories of CSA. Results supported a sequential mediation: CSA predicted greater maladaptive repertoires that, in turn, exacerbated the effects of stress on depression symptoms. Maladaptive responses also exacerbated the effects of daily life stress on contemporaneous negative affect (NA) levels and their increase over time. Independent of stress sensitization, emotion regulation deficits also mediated CSA effects on both depressive outcomes, though the effect of maladaptive strategies was specific to NA, and adaptive responses to positive affect. Our findings suggest that emotion regulation deficits and stress sensitization play key intervening roles between CSA and risk for depression.
Aortic root dilation in a child with Marfan syndrome and mosaic Turner syndrome
Authors: Groner Abraham , Qadir Asad
Published: October 2020

Patients with a known genetic cause of aortic root dilation usually have a single underlying aetiology, either a single gene defect as in Marfan syndrome or chromosomal anomaly as in Turner syndrome. However, it is possible, although unlikely, for a patient to inherit multiple independent risk factors for aortic root dilation. We describe such a patient, who inherited Marfan syndrome and a very unusual form of mosaic Turner syndrome. Long-term follow-up of this patient may provide insight into the natural history of this unique genetic combination.
Prehospital Treatment of Acute Pulmonary Edema with Intravenous Bolus and Infusion Nitroglycerin
Authors: Perlmutter Michael C. , Cohen Matthew W. , Stratton Nathan S. , Conterato Marc
Published: October 2020

Objective:

The study describes the implementation of a prehospital treatment algorithm that included intravenous (IV) bolus (IVB) nitroglycerin (NTG) followed by maintenance infusion for the treatment of acute pulmonary edema (APE) in a single, high-volume Emergency Medical Services (EMS) system.

Methods:

This is a retrospective chart review of patients who received IVB NTG for APE in a large EMS system in Minnesota and Wisconsin (USA). Inclusion criteria for treatment included a diagnosis of APE, systolic blood pressure ≥120mmHg, and oxygen saturation (SpO2) ≤93% following 800mcg of sublingual NTG. Patients received a 400mcg IVB of NTG, repeated every two minutes as needed, and subsequent infusion at 80mcg/min for transport times ≥10 minutes.

Results:

Forty-four patients were treated with IVB NTG. The median total bolus dose was 400mcg. Twenty patients were treated with NTG infusion following IVB NTG. The median infusion rate was 80mcg/min. For all patients, the initial median blood pressure was 191/113mmHg. Five minutes following IVB NTG, it was 160/94mmHg, and on arrival to the emergency department (ED) it was 152/90mmHg. Five minutes after the initial dose of IVB NTG, median SpO2 increased to 92% from an initial reading of 88% and was 94% at hospital arrival. One episode of transient hypotension occurred during EMS transport.

Conclusion:

Patients treated with IVB NTG for APE had reduction in blood pressure and improvement in SpO2 compared to their original presentation. Prehospital treatment of APE with IVB appears to be feasible and safe. A randomized trial is needed to confirm these findings.
Absconsion in forensic psychiatric services: a systematic review of literature
Authors: Olagunju Andrew T. , Bouskill Stephanie L. , Olagunju Tinuke O. , Prat Sebastien S. , Mamak Mini , Chaimowitz Gary A.
Published: October 2020

While serious concerns are often raised when patients abscond or leave unauthorized from psychiatric services, there is limited knowledge about absconsion in forensic psychiatric services. Following the preferred reporting items for systematic reviews and meta-analyses guideline, we searched Medline/PubMed, PsycINFO, EMBASE, CINAHL, Scopus, and Web of Science through May 2020 for eligible reports on absconsion in forensic patients with no language limits. The search string combined terms for absconsion, forensic patients, and psychiatry in various permutations. This was supplemented by snowball searching for additional studies. Of the 565 articles screened, 25 eligible studies, including two interventional, seven cross-sectional, and 16 case-controlled studies spanning five decades were included. Absconsion and re-absconsion rates ranged from 0.2% to 54.4% and 15% to 71%, respectively, albeit higher rates trended with less secure psychiatric units. Previous absconsion, aggression, substance use, high Historical Clinical Risk Management-20 score, anti-sociality, psychiatric symptoms, sexual offending, and poor treatment adherence were the factors reported with a degree of predictive value for absconsion. However, the construct of absconsion was heterogeneous in the included studies and the quality of evidence on the predictors of absconsion was limited. Serious risky behaviors including re-offending, violence, self-harm, suicide, rape, and manslaughter were perpetrated by patients during unauthorized leave. Nevertheless, the rates of re-offending were generally low in the included studies (highest recidivism rate = 0.11). There is need for standardized assessment and documentation of absconsion to improve risk analysis and management. Furthermore, it is necessary to develop a structured guideline for defining absconsion, and to create a protocol that operationalizes all absconsion-related behaviors/events to promote reliable assessment and comparative analysis in future studies.
Associations between nutrient intakes and dietary patterns with different sarcopenia definitions in older Australian men: the concord health and ageing in men project
Authors: Das Arpita , Cumming Robert G , Naganathan Vasi , Blyth Fiona , Le Couteur David G , Handelsman David J , Waite Louise M , Ribeiro Rosilene V , Simpson Stephen J , Hirani Vasant
Published: October 2020

Objective:

To assess the associations between nutrient intake and dietary patterns with different sarcopenia definitions in older men.

Design:

Cross-sectional study.

Setting:

Sarcopenia was defined using the Foundation for the National Institutes of Health (FNIH), the European Working Group on Sarcopenia in Older People (EWGSOP) and the European Working Group on Sarcopenia in Older People 2 (EWGSOP2). Dietary adequacy of fourteen nutrients was assessed by comparing participants’ intakes with the Nutrient Reference Values (NRV). Attainment of NRV for nutrients was incorporated into a variable ‘poor’ (meeting ≤ 9) v. ‘good’ (meeting ≥ 10) using the cut-point method. Also, two different dietary patterns, monounsaturated:saturated fat and n-6:n-3 fatty acids ratio and individual nutrients were used as predictor variables.

Participants:

A total of 794 men aged ≥75 years participated in this study.

Results:

The prevalence of sarcopenia by the FNIH, EWGSOP and EWGSOP2 definitions was 12·9 %, 12·9 % and 19·6 %, respectively. With the adjustment, poor nutrient intake was significantly associated with FNIH-defined sarcopenia (OR: 2·07 (95 % CI 1·16, 3·67)), but not with EWGSOP and EWGSPOP2 definitions. The lowest and second-lowest quartiles of protein, Mg and Ca and the lowest quartiles of n-6 PUFA and n-3 PUFA intakes were significantly associated with FNIH-defined sarcopenia. Each unit decrease in n-6:n-3 ratio was significantly associated with a 9 % increased risk of FNIH-defined sarcopenia (OR: 1·09 (95 % CI 1·04, 1·16)).

Conclusions:

Inadequate intakes of nutrients are associated with FNIH-defined sarcopenia in older men, but not with the other two sarcopenia definitions. Further studies are required to understand these relationships.
Sleep, social behaviour and food consumption of schoolchildren of a large Brazilian city
Authors: da Silva Adriana Cândida , Vieira Érica Leandro Marciano , dos Santos Luana Caroline
Published: October 2020

Objective:

To explore the impact of inadequate sleep and associated factors on the social behaviour and food consumption of children and adolescents.

Design:

Cross-sectional study.

Setting:

Sleep information, social behaviour (Strengths and Difficulties Questionnaire), food consumption, demography, nutritional status, lifestyle, and biochemical tests were investigated.

Participants:

School children in the 4th grade of the municipal school system of a large Brazilian city.

Results:

Of a total of 797 schoolchildren, 50·9 % were female, with a median age of 9·7 (9·5–10·0) years old and an energy consumption of 7613·6 (5982·7–9766·2) kJ. It was determined that 31·6 % were overweight, and 76·8 % reported insufficient weekly practice of physical activity. A median of 9·6 (8·9–10·5) h of sleep (lower values on weekdays: 9·3 v. 10·5 h, P < 0·001) was recorded. In addition, 27 % of the individuals who experienced inadequate sleep (<9 h) engaged in longer screen time daily (≥2 h/d) (P = 0·05), had an inadequate bedtime (> 22 h) or adequate wake-up time (5–7 h), studied in the morning (P < 0·001) and never took a shower before school (P < 0·001). Of the entire sample, 9·9 % had poor or very poor sleep quality and a greater probability of sleep talking regularly, had difficulty falling asleep, and engaged in inadequate social behaviour while experiencing these conditions compared with those with positive sleep quality. There was no association between sleep and the other variables investigated.

Conclusions:

Sleep impairment contributed to changes in sleep and social behaviour in schoolchildren. The findings of this study may reinforce the importance of developing actions to promote adequate sleep and a healthy lifestyle at school age.
How Lithology Impacts Global Topography, Vegetation, and Animal Biodiversity: A Global‐Scale Analysis of Mountainous Regions
Authors: Ott Richard F.
Published: October 2020

Chemical and mechanical properties of lithology exert a first‐order control on landscape evolution and biological colonization of substrate. To quantify the influence of lithology on topography, vegetation density, and animal biodiversity, I compile lithologic, topographic, climatic, and biological data sets for mountainous regions globally. I find significant variations in the topographic steepness of regions underlain by different lithologies that, accounting for tectonic uplift, likely reflect lithologic differences in erosional resistance. These relative differences in erodibility are similar across different climate zones. To isolate the effect of lithology on vegetation and animal biodiversity, I account for the heterogeneous lithologic distribution among climate zones. I show that siliciclastic, plutonic, and, for some biological variables, metamorphic rocks exhibit elevated values of Normalized Difference Vegetation Index and tetrapod and amphibian species richness relative to carbonate rocks. These results likely reflect lithology‐related variation in soil nutrients and hydrology that promote or inhibit habitat suitability.
Microstructural Controls on Thermal Crack Damage and the Presence of a Temperature‐Memory Effect During Cyclic Thermal Stressing of Rocks
Authors: Daoud Ali , Browning John , Meredith Philip G. , Mitchell Thomas M.
Published: October 2020

We present results from a series of thermal stressing experiments that used three igneous rocks of different composition, grain size, and origin and contemporaneously recorded acoustic emissions (AEs) with changing temperature. Samples were subjected to both a single heating and cooling cycle and multiple heating/cooling cycles to different peak temperatures. The vast majority of thermal crack damage is generated during heating in the coarser‐grained (quartz rich) rock but during cooling in the two finer‐grained (quartz poor) rocks. Our AE results also demonstrate the presence of a temperature‐memory effect, analogous to the Kaiser stress‐memory effect observed during cyclic mechanical loading, but only in the coarser‐grained rock. We suggest that the total amount of crack damage induced during either heating or cooling is dependent on the mineral composition and, most importantly, the grain size and arrangement, as well as the maximum temperature to which the rock was exposed. We use our laboratory‐scale results to suggest ways in which crustal‐scale geophysical data may need to be reinterpreted to provide more accurate estimates of total, accumulated damage and the approach to macroscopic failure in crustal segments hosting magma chambers and geothermal reservoirs.
Quantifying Key Mechanisms That Contribute to the Deviation of the Tropical Warming Profile From a Moist Adiabat
Authors: Miyawaki Osamu , Tan Zhihong , Shaw Tiffany A. , Jansen Malte F.
Published: October 2020

Climate models project tropical warming is amplified aloft relative to the surface in response to increased CO2. Here we show moist adiabatic adjustment overpredicts the multimodel mean 300 hPa temperature response by 16.6–25.3% across the CMIP5 model hierarchy. We show three mechanisms influence overprediction: climatological large‐scale circulation, direct effect of increased CO2, and convective entrainment. Accounting for the presence of a climatological large‐scale circulation and the direct effect of CO2 reduces the CMIP5 multimodel mean overprediction by 0.7–7.2% and 2.8–3.9%, respectively, but does not eliminate it. To quantify the influence of entrainment, we vary the Tokioka parameter in aquaplanet simulations. When entrainment is decreased by decreasing the Tokioka parameter from 0.1 to 0, overprediction decreases by 9.6% and 10.4% with and without a large‐scale circulation, respectively. The sensitivity of overprediction to climatological entrainment rate in the aquaplanet mostly follows the predictions of zero‐buoyancy bulk‐plume and spectral‐plume models.
A Statistical/Dynamical Model for North Atlantic Seasonal Hurricane Prediction
Authors: Klotzbach P. J. , Caron L.‐P. , Bell M. M.
Published: October 2020

Colorado State University (CSU) has been issuing seasonal hurricane forecasts since 1984, with statistical modeling techniques primarily underpinning these outlooks. CSU has recently begun issuing statistical/dynamical forecasts, using the SEAS5 forecast system from the European Centre for Medium‐Range Weather Forecasts to forecast the three predictors that currently comprise CSU's early August statistical forecast model. SEAS5 shows skill at forecasting all three of these July predictors from an initialization as early as 1 March. The SEAS5 model forecasts for the three parameters are then regressed against seasonal accumulated cyclone energy. The model has a cross‐validated correlation skill of r = 0.60 with accumulated cyclone energy for a 1 March initialization, improving to r = 0.67 for a 1 June initialization over the period from 1982–2019. The combination of the statistical/dynamical model with the currently existing statistical models shows improved skill over either model individually for the April, June, and July outlooks.
Thickness of Lava Flows Within the Northern Smooth Plains on Mercury as Estimated by Partially Buried Craters
Authors: Du Jun , Wieczorek Mark A. , Fa Wenzhe
Published: October 2020

Partially and completely buried impact craters are widely distributed over the northern smooth plains of Mercury. Using imagery data acquired from the MESSENGER mission, we compiled a database of 257 partially buried and 765 completely buried craters on Mercury. The elevation profiles of fresh craters were constructed, and by inputting these into a topographic degradation model, we estimated the lava flow thicknesses around partially buried craters. Along the edges of the northern smooth plains, lava flow thicknesses were inverted to be 23–536 m with a median of 228 m. Lava flow thicknesses on Mercury are twice that on the Moon, possibly due to a denser crust on Mercury that favors the ascent of magmas or to higher production rates of magmas. The topographic diffusivity used for crater degradation on Mercury is 3 times that for lunar craters, which is likely a result of a higher cratering rate on Mercury.
Creep Along the Central San Andreas Fault From Surface Fractures, Topographic Differencing, and InSAR
Authors: Scott Chelsea , Bunds Michael , Shirzaei Manoochehr , Toke Nathan
Published: October 2020

Imaging tectonic creep along active faults is critical for measuring strain accumulation and ultimately understanding the physical processes that guide creep and the potential for seismicity. We image tectonic deformation along the central creeping section of the San Andreas Fault at the Dry Lake Valley paleoseismic site (36.468°N, 121.055°W) using three data sets with varying spatial and temporal scales: (1) an Interferometric Synthetic Aperture Radar (InSAR) velocity field with an ~100‐km footprint produced from Sentinel‐1 satellite imagery, (2) light detection and ranging (lidar) and structure‐from‐motion 3‐D topographic differencing that resolves a decade of deformation over a 1‐km aperture, and (3) surface fractures that formed over the 3‐ to 4‐m wide fault zone during a drought from late 2012 to 2014. The InSAR velocity map shows that shallow deformation is localized to the San Andreas Fault. We demonstrate a novel approach for differencing airborne lidar and structure‐from‐motion topography that facilitates resolving deformation along and adjacent to the San Andreas Fault. The 40‐m resolution topographic differencing resolves a 2.5 ± 0.2 cm/yr slip rate localized to the fault. The opening‐mode fractures accommodate
 cm/yr of fault slip. A 90% ± 30% of the 1‐km aperture deformation is accommodated over the several meter‐wide surface trace of the San Andreas Fault. The extension direction inferred from the opening‐mode fractures and topographic differencing is 40°–48° from the local trend of the San Andreas Fault. The localization of deformation likely reflects the well‐oriented and mature fault.
Ice Sheet Changes and GIA‐Induced Surface Displacement of the Larsemann Hills During the Last 50 kyr
Authors: Gao Yuesong , Yang Lianjiao , Mei Yanjun , Chu Zhuding , Yang Wenqing , Xu Qibin , Chen Guangjie , Xie Zhouqing , Sun Liguang
Published: October 2020

The Antarctic Ice Sheet (AIS) is the largest potential source for future global sea level rise. However, there are widely diverging estimates of its contribution, which emphasizes the need to improve our understanding of the long‐term behavior of the AIS and its impact on the solid Earth. This knowledge gap results from a shortage of records of glacial history, especially for the pre‐Holocene. Marine transgression and recession in the coastal areas of Antarctica are influenced by the mass of the overlying ice, providing crucial information about regional ice sheet dynamics. In this study, we determined a marine transgression from 53 kyr BP onward by diatom assemblages and a δ13C‐C/N biplot for the organic component in a sediment core (MCM2), from the Larsemann Hills in East Antarctica. Relative sea level (RSL) reached a maximum of ~12 m a.p.s.l. (above present sea level) during 38–29 kyr BP. Concurrent with the transgression, the regional crust experienced glacial‐isostatic‐adjustment (GIA)‐induced subsidence from ~75 to ~95 m beneath the present land level, suggesting an expansion trend of the East Antarctic ice sheet (EAIS), which may have outpaced global cooling. After the last deglaciation, the RSL rose to a highstand of ~8–10 m a.p.s.l. at ~8.5–7.1 kyr BP, when the bedrock uplifted to ~20 m below the present level. After 4.0 kyr BP, both regional and global deglaciation ceased, but an effect of ongoing relaxation caused the land to rebound continuously at a uniform rate of ~1.5 m/kyr, which can account for the sustained fall of RSL across Antarctica since mid‐Holocene.
The Sensitivity of Atmospheric River Identification to Integrated Water Vapor Transport Threshold, Resolution, and Regridding Method
Authors: Reid Kimberley J. , King Andrew D. , Lane Todd P. , Short Ewan
Published: October 2020

Atmospheric rivers (ARs) are elongated narrow bands of enhanced water vapor that can cause intense rainfall and flooding. ARs only appeared in the literature the last 30 years, and there has been much debate about how to define ARs and how to identify them. As a result, a wide range of AR identification algorithms have been produced with variations in the conditions required for an object to be classified as an AR and differences in the input data. One of the key conditions in most AR identification algorithms is a minimum threshold of water vapor flux, along with geometric criteria. The aim of this study is to explore uncertainties in global AR identification based on a single integrated water vapor transport (IVT)‐based identification method. We conduct a sensitivity analysis under one algorithmic framework to explore the effects of different IVT thresholds, input data resolutions, and regridding methods during the Years of Tropical Convection operational analysis (May 2008 to April 2010). We found that the resolution and regridding method affects the number of ARs identified but the seasonal cycle is maintained. AR identification is highly sensitive to the choice of IVT threshold; importantly, the commonly used 250 kg m−1 s−1 IVT threshold is not appropriate for global studies with detection methods that also include a restrictive geometric condition as this combination can lead to the strongest systems failing to be identified. The uncertainties within a single AR detection method and input data parameters may be as large as uncertainties across AR detection methodologies.
A multivariate neuromonitoring approach to neuroplasticity-based computerized cognitive training in recent onset psychosis
Authors: Haas Shalaila S. , Antonucci Linda A. , Wenzel Julian , Ruef Anne , Biagianti Bruno , Paolini Marco , Rauchmann Boris-Stephan , Weiske Johanna , Kambeitz Joseph , Borgwardt Stefan , Brambilla Paolo , Meisenzahl Eva , Salokangas Raimo K. R. , Upthegrove Rachel , Wood Stephen J. , Koutsouleris Nikolaos , Kambeitz-Ilankovic Lana
Published: October 2020

Two decades of studies suggest that computerized cognitive training (CCT) has an effect on cognitive improvement and the restoration of brain activity. Nevertheless, individual response to CCT remains heterogenous, and the predictive potential of neuroimaging in gauging response to CCT remains unknown. We employed multivariate pattern analysis (MVPA) on whole-brain resting-state functional connectivity (rsFC) to (neuro)monitor clinical outcome defined as psychosis-likeness change after 10-hours of CCT in recent onset psychosis (ROP) patients. Additionally, we investigated if sensory processing (SP) change during CCT is associated with individual psychosis-likeness change and cognitive gains after CCT. 26 ROP patients were divided into maintainers and improvers based on their SP change during CCT. A support vector machine (SVM) classifier separating 56 healthy controls (HC) from 35 ROP patients using rsFC (balanced accuracy of 65.5%,P < 0.01) was built in an independent sample to create a naturalistic model representing the HC-ROP hyperplane. This model was out-of-sample cross-validated in the ROP patients from the CCT trial to assess associations between rsFC pattern change, cognitive gains and SP during CCT. Patients with intact SP threshold at baseline showed improved attention despite psychosis status on the SVM hyperplane at follow-up (p < 0.05). Contrarily, the attentional gains occurred in the ROP patients who showed impaired SP at baseline only if rsfMRI diagnosis status shifted to the healthy-like side of the SVM continuum. Our results reveal the utility of MVPA for elucidating treatment response neuromarkers based on rsFC-SP change and pave the road to more personalized interventions.
Overview of current targeted therapy in gallbladder cancer
Authors: Song Xiaoling , Hu Yunping , Li Yongsheng , Shao Rong , Liu Fatao , Liu Yingbin
Published: October 2020

Gallbladder cancer (GBC) is rare, but is the most malignant type of biliary tract tumor. Unfortunately, only a small population of cancer patients is acceptable for the surgical resection, the current effective regimen; thus, the high mortality rate has been static for decades. To substantially circumvent the stagnant scenario, a number of therapeutic approaches owing to the creation of advanced technologic measures (e.g., next-generation sequencing, transcriptomics, proteomics) have been intensively innovated, which include targeted therapy, immunotherapy, and nanoparticle-based delivery systems. In the current review, we primarily focus on the targeted therapy capable of specifically inhibiting individual key molecules that govern aberrant signaling cascades in GBC. Global clinical trials of targeted therapy in GBC are updated and may offer great value for novel pathologic and therapeutic insights of this deadly disease, ultimately improving the efficacy of treatment.
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications
Authors: Ju Huai-Qiang , Lin Jin-Fei , Tian Tian , Xie Dan , Xu Rui-Hua
Published: October 2020

Nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron donor in all organisms, and provides the reducing power for anabolic reactions and redox balance. NADPH homeostasis is regulated by varied signaling pathways and several metabolic enzymes that undergo adaptive alteration in cancer cells. The metabolic reprogramming of NADPH renders cancer cells both highly dependent on this metabolic network for antioxidant capacity and more susceptible to oxidative stress. Modulating the unique NADPH homeostasis of cancer cells might be an effective strategy to eliminate these cells. In this review, we summarize the current existing literatures on NADPH homeostasis, including its biological functions, regulatory mechanisms and the corresponding therapeutic interventions in human cancers, providing insights into therapeutic implications of targeting NADPH metabolism and the associated mechanism for cancer therapy.
CPX-351 treatment in secondary acute myeloblastic leukemia is effective and improves the feasibility of allogeneic stem cell transplantation: results of the Italian compassionate use program
Authors: Guolo Fabio , Fianchi Luana , Minetto Paola , Clavio Marino , Gottardi Michele , Galimberti Sara , Rizzuto Giuliana , Rondoni Michela , Bertani Giambattista , Dargenio Michela , Bilio Atto , Scappini Barbara , Zappasodi Patrizia , Scattolin Anna Maria , Grimaldi Francesco , Pietrantuono Giuseppe , Musto Pellegrino , Cerrano Marco , D’Ardia Stefano , Audisio Ernesta , Cignetti Alessandro , Pasciolla Crescenza , Pavesi Francesca , Candoni Anna , Gurreri Carmela , Morselli Monica , Alati Caterina , Fracchiolla Nicola , Rossi Giovanni , Caizzi Manuela , Carnevale-Schianca Fabrizio , Tafuri Agostino , Rossi Giuseppe , Ferrara Felicetto , Pagano Livio , Lemoli Roberto Massimo
Published: October 2020

Secondary acute myeloid leukemia (sAML) poorly responds to conventional treatments and allogeneic stem cell transplantation (HSCT). We evaluated toxicity and efficacy of CPX-351 in 71 elderly patients (median age 66 years) with sAML enrolled in the Italian Named (Compassionate) Use Program. Sixty days treatment-related mortality was 7% (5/71). The response rate at the end of treatment was: CR/CRi in 50/71 patients (70.4%), PR in 6/71 (8.5%), and NR in 10/71 (19.7%). After a median follow-up of 11 months relapse was observed in 10/50 patients (20%) and 12 months cumulative incidence of relapse (CIR) was 23.6%. Median duration of response was not reached. In competing risk analysis, CIR was reduced when HSCT was performed in first CR (12 months CIR of 5% and 37.4%, respectively, for patients receiving (=20) or not (=30) HSCT, p = 0.012). Twelve-months OS was 68.6% (median not reached). In landmark analysis, HSCT in CR1 was the only significant predictor of longer survival (12 months OS of 100 and 70.5%, for patients undergoing or not HSCT in CR1, respectively, p = 0.011). In conclusion, we extend to a real-life setting, the notion that CPX is an effective regimen for high risk AML patients and may improve the results of HSCT.
FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome
Authors: Schieber Michael , Marinaccio Christian , Bolanos Lyndsey C. , Haffey Wendy D. , Greis Kenneth D. , Starczynowski Daniel T. , Crispino John D.
Published: October 2020

Myelodysplastic syndrome (MDS) is a heterogeneous myeloid malignancy characterized by blood cell morphological dysplasia, ineffective clonal hematopoiesis, and risk of transformation to secondary acute myeloid leukemia (sAML). A number of genetic abnormalities have been identified in MDS and sAML, but sensitive sequencing methods can detect these mutations in nearly all healthy individuals by 60 years of age. To discover novel cellular pathways that accelerate MDS and sAML, we performed a CRISPR/Cas9 screen in the human MDS-L cell line. We report here that loss of the F-Box protein FBXO11, a component of the SCF ubiquitin ligase complex, confers cytokine independent growth to MDS-L cells, suggesting a tumor suppressor role for FBXO11 in myeloid malignancies. Putative FBXO11 substrates are enriched for proteins with functions in RNA metabolism and, of note, spliceosome mutations that are commonly found in MDS/sAML are rare in patients with low FBXO11 expression. We also reveal that loss of FBXO11 leads to significant changes in transcriptional pathways influencing leukocyte proliferation, differentiation, and apoptosis. Last, we find that FBXO11 expression is reduced in patients with secondary AML. We conclude that loss of FBXO11 is a mechanism for disease transformation of MDS into AML, and may represent a future therapeutic target.