bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) Combined with Psychological Interventions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Xu Xiaomin , Xu Mei , Su Yon , Cao Thanh Vinh , Nikolin Stevan , Moffa Adriano , Loo Colleen , Martin Donel
Published: November 2023

(1) Background: Psychological interventions are effective in alleviating neuropsychiatric symptoms, though results can vary between patients. Repetitive transcranial magnetic stimulation (rTMS) has been proven to improve clinical symptoms and cognition. It remains unclear whether rTMS can augment the efficacy of psychological interventions. (2) Methods: We examined the effects of rTMS combined with psychological interventions on clinical, functional, and cognitive outcomes from randomized controlled trials conducted in healthy and clinical populations. We searched PubMed, EMBASE, Cochrane Library, and PsycINFO databases up to April 2023. (3) Results: Twenty-seven studies were ultimately included. Compared to sham rTMS combined with psychological interventions, active rTMS combined with psychological interventions significantly improved overall clinical symptoms (k = 16, SMD  =  0.31, CIs 0.08 to 0.54, p  <  0.01). We found that 10 or more sessions of rTMS combined with cognitive behavioural therapy significantly improved clinical outcomes overall (k = 3, SMD  =  0.21, CIs  0.05 to 0.36, Z = 2.49, p  <  0.01). RTMS combined with cognitive training (CT) significantly improved cognition overall compared to sham rTMS combined with CT (k = 13, SMD  =  0.28, CIs 0.15 to 0.42, p  <  0.01), with a significant effect on global cognition (k = 11, SMD  =  0.45, CIs 0.21 to 0.68, p  < 0.01), but not on the other cognitive domains. (4) Conclusion: The current results provide preliminary support for the augmentation effects of active rTMS on clinical and cognitive outcomes across diverse populations. Future clinical trials are required to confirm these augmentation effects for specific psychological interventions in specific clinical populations.
Hybrid Cellular Automata Modeling Reveals the Effects of Glucose Gradients on Tumour Spheroid Growth
Authors: Messina Luca , Ferraro Rosalia , Peláez Maria J. , Wang Zhihui , Cristini Vittorio , Dogra Prashant , Caserta Sergio
Published: November 2023

Purpose: In recent years, mathematical models have become instrumental in cancer research, offering insights into tumor growth dynamics, and guiding the development of pharmacological strategies. These models, encompassing diverse biological and physical processes, are increasingly used in clinical settings, showing remarkable predictive precision for individual patient outcomes and therapeutic responses. Methods: Motivated by these advancements, our study introduces an innovative in silico model for simulating tumor growth and invasiveness. The automated hybrid cell emulates critical tumor cell characteristics, including rapid proliferation, heightened motility, reduced cell adhesion, and increased responsiveness to chemotactic signals. This model explores the potential evolution of 3D tumor spheroids by manipulating biological parameters and microenvironment factors, focusing on nutrient availability. Results: Our comprehensive global and local sensitivity analysis reveals that tumor growth primarily depends on cell duplication speed and cell-to-cell adhesion, rather than external chemical gradients. Conversely, tumor invasiveness is predominantly driven by chemotaxis. These insights illuminate tumor development mechanisms, providing vital guidance for effective strategies against tumor progression. Our proposed model is a valuable tool for advancing cancer biology research and exploring potential therapeutic interventions.
Catalysts in Energy Applications
Authors: Levin Oleg V.
Published: November 2023

Catalysis stands as a fundamental driver in the energy landscape, influencing processes across the entire energy life cycle [...]
New Insights into the Effect of Ce Doping on the Catalytic Performance and Hydrothermal Stability of Cu-USY Zeolite Catalysts for the Selective Catalytic Reduction of NO with NH3
Authors: Sun Qi , Yang Haipeng , Wan Jie , Hua Wanru , Liu Yanjun , Wang Xiaoli , Shi Chunxiao , Shi Qingai , Wu Gongde , Zhou Renxian
Published: November 2023

5Cu-USY and Ce-doped 5Cu8Ce-USY zeolite catalysts were prepared by the conventional impregnation method. The obtained catalysts were subjected to the hydrothermal ageing process. The catalytic performance of the selective catalytic reduction of NOx with NH3 (NH3-SCR) was evaluated on both fresh and aged catalysts. Physical/chemical characterizations such as X-ray diffraction (XRD), H2 temperature-programmed reduction (H2-TPR), and X-ray photoelectron spectroscopy (XPS) were performed, along with detailed in situ diffuse reflectance infrared Fourier-transform spectroscopy (DRIFTS) experiments including CO adsorption, NH3 adsorption, and NO + O2 reactions. Results showed that, for the 5Cu-USY catalyst, hydrothermal ageing treatment could somehow improve the low-temperature SCR activity, but it also led to significant formation of unfavorable byproducts NO2 and N2O. Such an activity change can be attributed to hydrothermal ageing inducing the migration of isolated Cu+ species in the sodalite cavities towards the super cages of the USY zeolites. The increased content of Cu+ species in the super cages was beneficial for the low-temperature activity improvement, but, at the same time, it also facilitated ammonia oxidation at high temperatures. Ce doping after hydrothermal ageing has a “double-edged sword” effect on the catalytic performance. First of all, Ce doping can inhibit Cu species migration by self-occupying the internal cage sites; thus, the catalytic performance of 5Cu8Ce-USY-700H remains stable after ageing. Secondly, Ce doping introduces a CuOx–CeO2 strong interaction, which facilitates lattice oxygen mobility by forming more oxygen vacancies so as to increase the concentration of surface active oxygen. These changes, on the one hand, could help to promote further oxidative decomposition of nitrate/nitrite intermediates and improve the catalytic performance. But, on the other hand, it also causes the byproduct generation to become more severe.
Th17 Cells, Glucocorticoid Resistance, and Depression
Authors: Khantakova Julia N. , Mutovina Anastasia , Ayriyants Kseniya A. , Bondar Natalia P.
Published: November 2023

Depression is a severe mental disorder that disrupts mood and social behavior and is one of the most common neuropsychological symptoms of other somatic diseases. During the study of the disease, a number of theories were put forward (monoamine, inflammatory, vascular theories, etc.), but none of those theories fully explain the pathogenesis of the disease. Steroid resistance is a characteristic feature of depression and can affect not only brain cells but also immune cells. T-helper cells 17 type (Th17) are known for their resistance to the inhibitory effects of glucocorticoids. Unlike the inhibitory effect on other subpopulations of T-helper cells, glucocorticoids can enhance the differentiation of Th17 lymphocytes, their migration to the inflammation, and the production of IL-17A, IL-21, and IL-23 in GC-resistant disease. According to the latest data, in depression, especially the treatment-resistant type, the number of Th17 cells in the blood and the production of IL-17A is increased, which correlates with the severity of the disease. However, there is still a significant gap in knowledge regarding the exact mechanisms by which Th17 cells can influence neuroinflammation in depression. In this review, we discuss the mutual effect of glucocorticoid resistance and Th17 lymphocytes on the pathogenesis of depression.
Local Diagnostic Reference Levels for Pediatric Interventional Cardiology Procedures in Argentina
Authors: Azcurra Patricia , Leyton Fernando , Lucini Victorio , Rivarola Marcelo , Trentacoste Luis , Marques Adela , Chiabrando Juan , Seropian Ignacio , Mundo Nicolas , Ubeda Carlos , Agatiello Carla
Published: November 2023

The aim of this work was to propose a preliminary local diagnostic reference levels (DRL) for pediatric interventional cardiology (PIC) procedures in Argentina, for different ranges of age and weight. This work has been conducted in the framework of the “Optimization of Protection in Pediatric Interventional Radiology in Latin America and the Caribbean” (OPRIPALC) program coordinated by the World Health Organization and the Pan American Health Organization in cooperation with the International Atomic Energy Agency to ensuring that radiation exposures of pediatric patients are the minimum necessary during fluoroscopy-guided interventional procedures. The local DRL values presented in this paper by weight group and age group were 7.1 Gy·cm2 (<5 kg), 10.7 Gy·cm2 (5–15 kg), 18.0 Gy·cm2 (15–30 kg), 15.9 Gy·cm2 (30–50 kg), and 28.2 Gy·cm2 (50–80 kg) and 5.3 Gy·cm2 (<1), 11.2 Gy·cm2 (1 to 5<), 19.6 Gy·cm2 (5 to 10<), and 21.4 Gy·cm2 (10 to 16<), respectively. Our dose results are among the values found in other international studies; however, there is great potential for dose optimization.
Identification of Multiple Genetic Loci Related to Low-Temperature Tolerance during Germination in Maize (Zea maize L.) through a Genome-Wide Association Study
Authors: Yu Tao , Zhang Jianguo , Cao Jingsheng , Li Shujun , Cai Quan , Li Xin , Li Sinan , Li Yunlong , He Changan , Ma Xuena
Published: November 2023

Low-temperature stress during the germination stage is an important abiotic stress that affects the growth and development of northern spring maize and seriously restricts maize yield and quality. Although some quantitative trait locis (QTLs) related to low-temperature tolerance in maize have been detected, only a few can be commonly detected, and the QTL intervals are large, indicating that low-temperature tolerance is a complex trait that requires more in-depth research. In this study, 296 excellent inbred lines from domestic and foreign origins (America and Europe) were used as the study materials, and a low-coverage resequencing method was employed for genome sequencing. Five phenotypic traits related to low-temperature tolerance were used to assess the genetic diversity of maize through a genome-wide association study (GWAS). A total of 14 SNPs significantly associated with low-temperature tolerance were detected (−log10(P) > 4), and an SNP consistently linked to low-temperature tolerance in the field and indoors during germination was utilized as a marker. This SNP, 14,070, was located on chromosome 5 at position 2,205,723, which explained 4.84–9.68% of the phenotypic variation. The aim of this study was to enrich the genetic theory of low-temperature tolerance in maize and provide support for the innovation of low-temperature tolerance resources and the breeding of new varieties.
Phyto-Synthesis and Characterization of Silver Nanoparticles Using Box-Behnken Design and Its Anti-Alternaria Activity
Authors: Daniel Augustine Innalegwu , Al-Hashimi Ali , Keyster Marshall , Klein Ashwil
Published: November 2023

Alternaria alternata is a global fungal pathogen that causes symptoms such as leaf blight and seed rot resulting in economically significant yield losses in different varieties of crops. Green synthesis of nanoparticles is preferred over other methods of synthesis due to their safety, eco-friendly approach, and cost-effectiveness. Phyto-synthesis of silver nanoparticles (Ag-NPs) using seed extract of Abrus precatorious was optimized and characterized using the Box-Behnken design (BBD). Ag-NPs with a UVmax of 409.01 nm and a crystallite and particle size of 23.75 and 34.36 nm, respectively, were synthesized. In vitro anti-alternaria activity of Ag-NPs showed a concentration-dependent inhibition of the mycelia with a maximum inhibition of 54.61% at 200 ppm which was significantly different (p < 0.05) from propiconazole (1 ppm) with 100% inhibition. A scanning electron micrograph (SEM) of mycelia treated with 200 ppm of Ag-NPs showed a shrunken and shriveled mycelia while the ultrastructure of the mycelia under a transmission electron microscope (TEM) showed the alteration of the fungus cell wall and disappearance of cellular organelles compared to the control sample, while energy dispersive x-ray spectroscopy (EDX) analysis of the mycelia showed the localization of elemental Ag (0.95%) within the cell of the fungus compared to the control. The results of this study highlighted the antifungal potential of Ag-NPs against fungicide-resistant Alternaria alternata to reduce the environmental impact of synthetic fungicides.
Increasing the Efficiency of Emulsion Crystallization in Stirred Vessels by Targeted Application of Shear and Surfactant
Authors: Kaysan Gina , Elmlinger Linda , Kind Matthias
Published: November 2023

Emulsions containing crystalline dispersed phases hold significant importance in pharmaceutical, chemical, and life science industries. The industrial agitation and storage of these emulsions can prompt crystallization effects within the flow field, intersecting with the primary nucleation mechanisms. Notably, contact-mediated nucleation, in which subcooled droplets crystallize upon contact with a crystalline particle, and shear-induced crystallization due to droplet deformation, are both conceivable phenomena. This study delves into the crystallization processes of emulsions in a 1 L stirred vessel, integrating an ultrasonic probe to monitor droplet crystallization progression. By scrutinizing the influence of the flow field and of the emulsifiers stabilizing the droplets, our investigation unveils the direct impact of enhanced rotational speed on accelerating the crystallization rate, correlating with increased energy input. Furthermore, the concentration of emulsifiers is observed to positively affect the crystallization process. Significantly, this pioneering investigation marks the first evaluation of emulsion crystallization considering the overlapping nucleation mechanisms seen in industrial production of melt emulsions. The findings offer valuable insights for more systematic control strategies in emulsion crystallization processes, promising more efficient and sustainable industrial practices by enabling targeted application of shear and surfactants.
5-Fluoro-1-Methyl-Pyrazol-4-yl-Substituted Nitronyl Nitroxide Radical and Its 3d Metal Complexes: Synthesis, Structure, and Magnetic Properties
Authors: Kudryavtseva Ekaterina , Serykh Andrey , Ugrak Bogdan , Dutova Tatyana , Nasyrova Darina , Aleshin Dmitrii , Efimov Nikolay , Dorovatovskii Pavel , Bogomyakov Artem , Fokin Sergey , Romanenko Galina , Sergeeva Anna , Tretyakov Evgeny
Published: November 2023

The metal–radical approach is a well-established synthetic way toward multi-spin systems that relies on the coordination of stable radical ligands with transition metal ions. The advantage offered by the use of paramagnetic ligands is that metal–radical magnetic exchange coupling is direct between the magnetic orbitals of the radical and metal ion. With the aim of further exploring this approach, crystals of four heterspin complexes, [M(hfac)2LF]2 {M = Mn, Co, or Ni and hfac = hexafluoroacetylacetonate} and [Cu(hfac)2LF]n, were obtained using a new fluorinated pyrazolyl-substituted nitronyl nitroxide radical, 4,4,5,5-tetramethyl-2-(5-fluoro-1-methyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (LF) as a ligand. The newly synthesized complexes were fully characterized, including X-ray crystallography and magnetometry. XRD analysis revealed that complexes [M(hfac)2LF]2 have similar dimer structures in which a metal ion is in a six-coordinated environment with four O atoms from the two hfac ligands, one radical O atom, and one pyrazole N atom from ligand LF. Nonetheless, the packing patterns of the complexes were found to be considerably different. In [Mn(hfac)2LF]2, there are no magnetically important short contacts between manganese dimers. By contrast, in [Co(hfac)2LF]2 and [Ni(hfac)2LF]2, there are short contacts between non-coordinate O atoms of nitronyl nitroxide moieties. Magnetic behaviors of [M(hfac)2LF]2 showed that the M ions and the directly coordinated radicals are strongly antiferromagnetically coupled (JMn-ON = −84.1 ± 1.5 cm−1, JCo-ON = −134.3 ± 2.6 cm−1, and JNi-ON = −276.2 ± 2.1 cm−1; H^=−2JS⃑^MS⃑^NO). Notably, the magnetization of [Mn(hfac)2LF]2 having molecular structure proved to be accompanied by hysteresis. The [Cu(hfac)2LF]n complex has a chain-polymer structure with alternating magnetic fragments: three spin exchange clusters {ONO–Cu(II)–ONO} and {Cu(II)} ions. Despite the direct coordination of radicals, its magnetic properties are weakly ferromagnetic (JCu-ON = 14.8 ± 0.3 cm−1).
A Unified Empirical Equation for Determining the Mechanical Properties of Porous NiTi Alloy: From Nanoporosity to Microporosity
Authors: Galimzyanov Bulat N. , Nikiforov Georgy A. , Anikeev Sergey G. , Artyukhova Nadezhda V. , Mokshin Anatolii V.
Published: November 2023

The mechanical characteristics of a monolithic (non-porous) crystalline or amorphous material are described by a well-defined set of quantities. It is possible to change the mechanical properties by introducing porosity into this material; as a rule, the strength values decrease with the introduction of porosity. Thus, porosity can be considered an additional degree of freedom that can be used to influence the hardness, strength and plasticity of the material. In the present work, using porous crystalline NiTi as an example, it is shown that the mechanical characteristics such as the Young’s modulus, the yield strength, the ultimate tensile strength, etc., demonstrate a pronounced dependence on the average linear size l¯ of the pores. For the first time, an empirical equation is proposed that correctly reproduces the dependence of the mechanical characteristics on the porosity ϕ and on the average linear size l¯ of the pores in a wide range of sizes: from nano-sized pores to pores of a few hundred microns in size. This equation correctly takes into account the limit case corresponding to the monolithic material. The obtained results can be used directly to solve applied problems associated with the design of materials with the necessary combination of physical and mechanical characteristics, in particular, porous metallic biomaterials.
Sequencing Antibody Drug Conjugates in Breast Cancer: Exploring Future Roles
Authors: Fenton Mary Anne , Tarantino Paolo , Graff Stephanie L.
Published: November 2023

Antibody drug conjugates (ADCs) have emerged as a highly effective treatment strategy across breast cancer (BC) subtypes, including human epidermal growth factor receptor 2-positive (HER2+), hormone-receptor positive (ER/PR+), and triple-negative breast cancer (TNBC). Over the past twenty years, ADCs have undergone relevant evolutions, from target diversity to payload ratio, to linker design, allowing for a progressive increase in their efficacy. From the first-generation ADC, trastuzumab emtansine (T-DM1), approved in 2013 for HER2+ breast cancer, to next generation ADCs such as sacituzumab govitecan and trastuzumab deruxtecan, to emerging ADCs on the horizon, we continue to see unparalleled efficacy compared to traditional chemotherapy. However, each ADC has brought a new cadre of adverse events for clinicians and patients to manage. Importantly, with the development and approval of several ADCs to treat metastatic breast cancer, there are unanswered clinical questions surrounding how to optimally sequence treatment for patients who may be candidates for more than one ADC and, in general, how to treat patients beyond progression on ADCs. From bench to bedside, in this review, we will discuss the pharmacology and current indications for the novel ADCs trastuzumab deruxtecan and sacituzumab govitecan. Highlighting emerging ADCs and ongoing clinical trials, we will anticipate the changes in the breast cancer treatment paradigm. Lastly, we will outline the available data and current approaches for adverse event management and sequencing strategies for ADCs in clinical practice, including proposed mechanisms of resistance.
Inferred Rate of Default as a Credit Risk Indicator in the Bulgarian Bank System
Authors: Boutchaktchiev Vilislav
Published: November 2023

The inferred rate of default (IRD) was first introduced as an indicator of default risk computable from information publicly reported by the Bulgarian National Bank. We have provided a more detailed justification for the suggested methodology for forecasting the IRD on the bank-group- and bank-system-level based on macroeconomic factors. Furthermore, we supply additional empirical evidence in the time-series analysis. Additionally, we demonstrate that IRD provides a new perspective for comparing credit risk across bank groups. The estimation methods and model assumptions agree with current Bulgarian regulations and the IFRS 9 accounting standard. The suggested models could be used by practitioners in monthly forecasting the point-in-time probability of default in the context of accounting reporting and in monitoring and managing credit risk.
Quantifying the Macroeconomic Impact of COVID-19-Related School Closures through the Human Capital Channel
Authors: de la Maisonneuve Christine , Égert Balázs , Turner David
Published: November 2023

This paper uses a new measure of human capital, which distinguishes both quality and quantity components, to estimate the long-term effect of the COVID-19-related school closures on aggregate productivity through the human capital channel. Productivity losses build up over time and are estimated to range between 0.4% and 2.1% after 45 years, for 12 weeks and 2 years of school closure, respectively. These results appear to be broadly consistent with earlier findings in the literature. Two opposing effects might influence these estimates. Online teaching would lower economic costs while learning losses in tertiary education (not considered here) would inflate them. Policies aimed at improving the quality of education and adult training will be needed to offset or, at least, alleviate the impact of the pandemic on human capital.
A Fault-Tolerant Control Strategy for Three-Level Grid-Connected NPC Inverters after Single-Arm Failure with Optimized SVPWM
Authors: Huang Jingtao , Bai Feng , Yang Qing , Ren Shiyi
Published: November 2023

Three-level NPC inverters have been widely used in grid-connected systems due to their superior performance compared with two-level inverters, but more switches lead to high fault probability. Meanwhile, the neutral point potential (NPP) fluctuation of the DC link is an inherent problem of three-level NPC inverters. To keep the three-level NPC inverter running stably after single-arm failure, a fault-tolerant control strategy based on an optimised space vector pulse width modulation (SVPWM) is proposed in this paper. Firstly, the common-mode voltage (CMV) of the postfault three-level NPC inverter is analysed and then the preliminary synthesis principles of the reference voltage vector are determined. Then, in order to ensure the NPP balance and the quality of the grid-connected currents, the reference voltage vector synthesis rules are optimised, a low-pass filter (LPF) and a hysteresis comparator are designed, respectively, to ensure the quality of grid-connected currents and effectively decrease the DC link NPP deviation. Finally, the simulation results show that the proposed fault-tolerant control strategy can realize the stable and reliable operation of the grid-connected three-level NPC inverter after single-arm failure, and the CMV can be reduced significantly, the quality of grid-connected currents is also improved. The proposed fault-tolerant strategy also shows good performance when the grid-connected currents change.
Thyroid and Heart: A Fatal Pathophysiological Attraction in a Controversial Clinical Liaison
Authors: Pingitore Alessandro , Mastorci Francesca , Lazzeri Maria Francesca Lodovica , Vassalle Cristina
Published: November 2023

The thyroid–heart relationship has a long and articulated history of its own, a history that encompasses physiological and pathophysiological knowledge. In recent years, molecular biology studies, in an experimental context, have highlighted the extraordinary dialogue that exists among the two systems in the field of cardioprotection, which is an extremely important area for the treatment of cardiac diseases in both acute and chronic phases. In addition, in the last few years, several studies have been carried out on the prognostic impact of alterations in thyroid function, including subclinical ones, in heart disease, in particular in heart failure and acute myocardial infarction, with evidence of a negative prognostic impact of these and, therefore, with the suggestion to treat these alterations in order to prevent cardiac events, such as death. This review provides a comprehensive summary of the heart–thyroid relationship.
Species Classification and Carbon Stock Assessment of Mangroves in Qi’ao Island with Worldview-3 Imagery
Authors: Sun Yuchao , Ye Mingzhen , Jian Zhuokai , Ai Bin , Zhao Jun , Chen Qidong
Published: November 2023

Mangroves play a substantial role in the global carbon cycle and are highly productive. To evaluate the effectiveness of a remote-sensing image in mangrove-species classification and carbon stock assessment, we utilized Worldview-3 images to map the mangrove species in Qi’ao Island, Guangdong Province, China, using a Random Forest classifier. We compared the contribution of spectral features, derivation features, and textural features to the classification accuracy and found that textural features significantly improved the overall accuracy, achieving 92.44% with all features combined. According to field-survey results, the main mangrove species in Qi’ao Island were Sonneratia apetala (SA), Acanthus ilicifolius (AI), Kandelia candel (KC), Acrostichum aureum (AA), Aegiceras corniculatum (AC), and Heritiera littoralis (HL); there are also many reeds mixed with mangroves. According to classification results, the total area of the mangroves and reeds is about 451.86 ha; the SA was the dominant species with an area of 393.90 ha. We calculated the total carbon stock of mangroves on Qi’ao Island by integrating the area of different species and their average total carbon density for the first time. The total carbon stock of mangroves in Qi’ao Island is between 147.78–156.14 kt, which demonstrates the significant potential of mangroves in carbon sequestration.
A Comprehensive Survey Exploring the Multifaceted Interplay between Mobile Edge Computing and Vehicular Networks
Authors: Pashazadeh Ali , Nardini Giovanni , Stea Giovanni
Published: November 2023

In recent years, the need for computation-intensive applications in mobile networks requiring more storage, powerful processors, and real-time responses has risen substantially. Vehicular networks play an important role in this ecosystem, as they must support multiple services, such as traffic monitoring or sharing of data involving different aspects of the vehicular traffic. Moreover, new resource-hungry applications have been envisaged, such as autonomous driving or in-cruise entertainment, hence making the demand for computation and storage resources one of the most important challenges in vehicular networks. In this context, Mobile Edge Computing (MEC) has become the key technology to handle these problems by providing cloud-like capabilities at the edge of mobile networks to support delay-sensitive and computation-intensive tasks. In the meantime, researchers have envisaged use of onboard vehicle resources to extend the computing capabilities of MEC systems. This paper presents a comprehensive review of the most recent works related to MEC-assisted vehicular networks, as well as vehicle-assisted MEC systems. We illustrate the MEC system architecture and discuss its deployment in vehicular environments, as well as the key technologies to realize this integration. After that, we review the recent literature by identifying three different areas, i.e.: (i) MEC providing additional resources to vehicles (e.g., for task offloading); (ii) MEC enabling innovative vehicular applications (e.g., platooning), and (iii) vehicular networks providing additional resources to MEC systems. Finally, we discuss open challenges and future research directions, addressing the possible interplays between MEC systems and vehicular networks.
Enhanced Electrochemical and Safety Performance of Electrocatalytic Synthesis of NH3 with Walnut Shell-Derived Carbon by Introducing Sulfur
Authors: Wang Jin , Zheng Zhichao , Liu Bin , Wang Ziwei , Wang Shuang
Published: November 2023

An efficient catalyst is key to achieving the synthesis of electrochemical ammonia and improving safety. In this work, using biomass walnut shell as a carbon source and sodium thiosulfate as a sulfur source, sulfur-modified walnut shell-derived carbon material was synthesized via a simple low-temperature impregnation method at room temperature and atmospheric pressure as an effective electrochemical ammonia synthesis catalyst with high thermal stability. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), nitrogen adsorption–desorption apparatus, thermogravimetry (TG), and other characterization methods were applied to analyze the micro-morphology and physicochemical structure of the electrocatalyst. The synthesized ammonia performance of the catalyst was measured using an ultraviolet (UV) spectrophotometer and electrochemical workstation. The catalyst design used the doping of sulfur atoms to create rich catalytic active sites, while the presence of elemental sulfur on the catalyst surface provided hydrophobicity, which was conducive to inhibiting competitive hydrogen evolution reaction (HER) and enhancing the electrocatalytic ammonia synthesis performance of the catalyst. Under normal temperature and pressure conditions, when a voltage of −0.45 V was applied, the ammonia yield in 0.05 M H2SO4 electrolyte was 10.39 μgNH3 mgcat.−1 h−1. The results showed that the introduction of sulfur effectively improved the electrocatalytic and thermal safety performance of bio-derived carbon materials, and the test presented that the performance of the catalyst was stable and reusable.
Common Fixed-Point Theorems for Families of Compatible Mappings in Neutrosophic Metric Spaces
Authors: Ishtiaq Umar , Ahmad Khaleel , Ali Farhan , Faraz Moazzama , Argyros Ioannis K.
Published: November 2023

Sets, probability, and neutrosophic logic are all topics covered by neutrosophy. Moreover, the classical set, fuzzy set, and intuitionistic fuzzy set are generalized using the neutrosophic set. A neutrosophic set is a mathematical concept used to solve problems with inconsistent, ambiguous, and inaccurate data. In this article, we demonstrate some basic fixed-point theorems for any even number of compatible mappings in complete neutrosophic metric spaces. Our primary findings expand and generalize the findings previously established in the literature.
Research on Effective Thermal Conductivity in Porous Media Embedded with Randomly Distributed Damaged Tree-like Bifurcation Networks
Authors: Shao Yihao , Guo Xiuya , Wang Huili , Zhu Limei , Zheng Qian
Published: November 2023

Due to the complexity of the microstructure of porous media, it is of great significance to explore the heat transport mechanism in porous media in many engineering applications. In this study, an expression for effective thermal conductivity (ETC) of porous media embedded with randomly distributed damaged tree-like bifurcation networks is derived based on the theory of thermodynamics and fractal features of tree-like bifurcation networks. We investigate the effect of heat conduction and heat convection in porous media embedded with randomly distributed damaged tree-like bifurcation networks on the ETC of the porous media. It is found that our fractal model has good consistency with the existing available experimental data. In addition, the influence of the microstructural parameters of the model on heat transfer in the porous media is analyzed in detail. The research results can provide significant theoretical guidance for the development and design of heat transfer systems.
Mutants with Enhanced Multi-Stress Tolerance of Kluyveromyces marxianus and Their Ability for Ethanol Fermentation
Authors: Lertwattanasakul Noppon , Pattanakittivorakul Sornsiri , Nitiyon Sukanya , Matsutani Minenosuke , Oguchi Akihiro , Hirata Katsushi , Kosaka Tomoyuki , Limtong Savitree , Yamada Mamoru
Published: November 2023

Kluyveromyces marxianus is an attractive thermotolerant yeast species for ethanol production because of its ability to utilize various carbon sources as a fermentation substrate. The use of thermotolerant microorganisms enables the performance of high-temperature ethanol fermentation, which has several advantages, including the reduction of cooling costs and minimization of contamination risks. To improve K. marxianus for ethanol fermentation under stress conditions, two strains, DMKU 3-1042 and DMKU 3-118, were adapted for heat resistance and resistance to toxic substances in pulp wastewater from a paper mill, respectively, resulting in the generation of KMR1042 and KMR118, respectively. Both adapted mutants exhibited clumpy clusters of cells as pseudo-hyphae and altered colony morphology, and their sedimentation speeds were much faster than those of the corresponding parent strains. The two mutants showed stronger tolerance to various stresses and higher performance for ethanol production than those of the corresponding parent strains at high temperatures or in the presence of toxic substances. Genome sequencing analysis revealed that both mutants had disruption of the same gene, SWI5, despite adaptation under different stress conditions, suggesting that the formation of pseudo-hyphae is a common strategy of K. marxianus for coping with stresses.
Battery State-of-Health Evaluation for Roadside Energy Storage Systems in Electric Transportation
Authors: Deng Kailong , Shen Kaiyuan , Dong Zihao , Liang Zekai , Zhao Lei , Xu Ting , Yin Shunde
Published: November 2023

Battery health assessments are essential for roadside energy storage systems that facilitate electric transportation. This paper uses the samples from the charging and discharging data of the base station and the power station under different working conditions at different working hours and at different temperatures to demonstrate the decay of the battery health of a roadside energy storage system under different cycles. In this paper, for the first time, the predicted state-of-health values are obtained by extracting the characteristic quantities affecting the battery health based on three indicators: the internal resistance, the rate of change of voltage, and the change of temperature. Data on state of health are clustered by K-Means, GMM, K-Means++ and divided into high, medium, and low levels. Using a comparison of the three methods, GMM clustering appears to be the best at reflecting the charging and discharging capacity of the battery.
Polymer Gel Substrate: Synthesis and Application in the Intensive Light Artificial Culture of Agricultural Plants
Authors: Panova Gayane G. , Krasnopeeva Elena L. , Laishevkina Svetlana G. , Kuleshova Tatiana E. , Udalova Olga R. , Khomyakov Yuriy V. , Mirskaya Galina V. , Vertebny Vitaly E. , Zhuravleva Anna S. , Shevchenko Natalia N. , Yakimansky Alexander V.
Published: November 2023

This work is devoted to the description of the synthesis of hydrogels in the process of cryotropic gel formation based on copolymerization of synthesized potassium 3-sulfopropyl methacrylate and 2-hydroxyethyl methacrylate (SPMA-co-HEMA) and assessing the potential possibility of their use as substrates for growing plants in intensive light culture in a greenhouse. Gel substrates based on the SPMA-co-HEMA were created in two compositions, differing from each other in the presence of macro- and microelements, and their effects were studied on the plants’ physiological state (content of chlorophylls a and b, activity of catalase and peroxidase enzymes, intensity of lipid peroxidation, elemental compositions) at the vegetative period of their development and on the plants’ growth, productivity and quality of plant production at the final stages of development. Experiments were carried out under controlled microclimate conditions. Modern and standard generally accepted methods of gels were employed (ATR-FTIR and 13C NMR spectral studies, scanning electron microscopy, measurement of specific surface area and pore volume), as well as the methods of the physiological and chemical analysis of plants. The study demonstrated the swelling ability of the created gel substrates. Hydrogels’ structure, their specific surface area, porosity, and pore volume were investigated. Using the example of representatives of leaf, fruit and root vegetable crops, the high biological activity of gel substrates was revealed throughout the vegetation period. Species specificity in the reaction of plants to the presence of gel substrates in the root-inhabited environment was revealed. Lettuce, tomato and cucumber plants were more responsive to the effect of the gel substrate, and radish plants were less responsive. At the same time, more pronounced positive changes in plant growth, quality and productivity were observed in cucumber and lettuce in the variant of gel substrates with macro- and microelements and in tomato plants in both variants of gel substrates. Further research into the mechanisms of the influence of gel substrates on plants, as well as the synthesis of new gel substrates with more pronounced properties to sorb and retain moisture is promising.
Gelation Behaviour of Pluronic F127/Polysaccharide Systems Revealed via Thioflavin T Fluorescence
Authors: Balan George-Alin , Precupas Aurica , Matei Iulia
Published: November 2023

Fast, reliable methods for characterizing the micelle-to-gel transition in emerging Pluronic F127/polysaccharide materials are essential for tailoring their applications as in situ gelling delivery systems. This study describes a simple fluorimetric method based on the response to gelation of the molecular probe thioflavin T (ThT). The techniques employed are (second derivative) steady-state and synchronous fluorescence. The capabilities of ThT as gelation reporter are tested for three model systems: Pluronic F127 (P16.6%), Pluronic F127/alginate (P16.6%ALG2%) and Pluronic F127/hyaluronic acid (P16.6%HA0.5%). We demonstrate that the changes in the short and long wavelength emissions of ThT allow accurate determination of the critical gelation temperatures in the investigated systems. The spectroscopic data providing information at molecular level are complemented with differential scanning microcalorimetric results revealing additional macroscopic insight into the micellization process. The gelation study is preceded by a solvatochromic analysis of ThT.
Biosynthesis of Peptide Hydrogel–Titania Nanoparticle Composites with Antibacterial Properties
Authors: Binaymotlagh Roya , Hajareh Haghighi Farid , Di Domenico Enea Gino , Sivori Francesca , Truglio Mauro , Del Giudice Alessandra , Fratoddi Ilaria , Chronopoulou Laura , Palocci Cleofe
Published: November 2023

The photoantibacterial properties of titania nanoparticles (TiO2NPs) are attracting much interest, but the separation of their suspension limits their application. In this study, the encapsulation of commercial TiO2NPs within self-assembling tripeptide hydrogels to form hgel-TiO2NP composites with significant photoantibacterial properties is reported. The Fmoc-Phe3 hydrogelator was synthesized via an enzymatic method. The resulting composite was characterized with DLS, ζ-potential, SAXS, FESEM-EDS and rheological measurements. Two different concentrations of TiO2NPs were used. The results showed that, by increasing the TiO2NP quantity from 5 to 10 mg, the value of the elastic modulus doubled, while the swelling ratio decreased from 63.6 to 45.5%. The antimicrobial efficacy of hgel-TiO2NPs was tested against a laboratory Staphylococcus aureus (S. aureus) strain and two methicillin-resistant S. aureus (MRSA) clinical isolates. Results highlighted a concentration-dependent superior antibacterial activity of hgel-TiO2NPs over TiO2NPs in the dark and after UV photoactivation. Notably, UV light exposure substantially increased the biocidal action of hgel-TiO2NPs compared to TiO2NPs. Surprisingly, in the absence of UV light, both composites significantly increased S. aureus growth relative to control groups. These findings support the role of hgel-TiO2NPs as promising biocidal agents in clinical and sanitation contexts. However, they also signal concerns about TiO2NP exposure influencing S. aureus virulence.
RNA-Sequencing Analysis Reveals the Role of Mitochondrial Energy Metabolism Alterations and Immune Cell Activation in Form-Deprivation and Lens-Induced Myopia in Mice
Authors: Kim Hojung , Lee Wonmin , Kim Ye-Ah , Yu Sanghyeon , Jeong Jisu , Choi Yueun , Lee Yoonsung , Park Yong Hwan , Kang Min Seok , Kim Man S. , Kim Tae Gi
Published: November 2023

Myopia is a substantial global public health concern primarily linked to the elongation of the axial length of the eyeball. While numerous animal models have been employed to investigate myopia, the specific contributions of genetic factors and the intricate signaling pathways involved remain incompletely understood. In this study, we conducted RNA-seq analysis to explore genes and pathways in two distinct myopia-inducing mouse models: form-deprivation myopia (FDM) and lens-induced myopia (LIM). Comparative analysis with a control group revealed significant differential expression of 2362 genes in FDM and 503 genes in LIM. Gene Set Enrichment Analysis (GSEA) identified a common immune-associated pathway between LIM and FDM, with LIM exhibiting more extensive interactions. Notably, downregulation was observed in OxPhos complex III of FDM and complex IV of LIM. Subunit A of complex I was downregulated in LIM but upregulated in FDM. Additionally, complex V was upregulated in LIM but downregulated in FDM. These findings suggest a connection between alterations in energy metabolism and immune cell activation, shedding light on a novel avenue for understanding myopia’s pathophysiology. Our research underscores the necessity for a comprehensive approach to comprehending myopia development, which integrates insights from energy metabolism, oxidative stress, and immune response pathways.
The Role of Platelet Molecules in Risk Stratification of Patients with COVID-19
Authors: de Oliveira Sales Lívia , de Oliveira Lais Lacerda Brasil , da Silva Jean Breno Silveira , de Moraes Filho Manoel Odorico , de Moraes Maria Elisabete Amaral , Montenegro Raquel Carvalho , Moreira-Nunes Caroline Aquino
Published: November 2023

The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in China and is responsible for Coronavirus disease (COVID-19). Despite being well tolerated by most patients, a fraction of cases evolve into a potentially fatal condition requiring intensive care. In addition to respiratory complications, several studies have reported cases of patients who developed intense thrombosis, including acute myocardial infarction and ischemic stroke, as well as the presence of elevated coagulation markers. Evidence has shown that the virus can interact directly with platelets and modulate their thrombotic and inflammatory functions, with significant prognostic implications. It is important to highlight that the emerging literature shows that when hyperactive these cells can act as pro-viral infections both in transporting their particles and in increasing inflammation, leading to a hyperinflammatory state and consequent clinical worsening. In this review, we searched for studies available in public databases and discussed the interaction of platelet biomarkers in the pathogenesis of COVID-19. In this context, understanding the mechanism of SARS-CoV-2 and these cells in different clinical conditions could help us to understand the coagulation and inflammation profiles of critically ill patients with the disease, guiding faster clinical management and enabling the reuse and targeting of more efficient therapies.
Experimenting with Training a Neural Network in Transkribus to Recognise Text in a Multilingual and Multi-Authored Manuscript Collection
Authors: Capurro Carlotta , Provatorova Vera , Kanoulas Evangelos
Published: November 2023

This work aims at developing an optimal strategy to automatically transcribe a large quantity of uncategorised, digitised archival documents when resources include handwritten text by multiple authors and in several languages. We present a comparative study to establish the efficiency of a single multilingual handwritten text recognition (HTR) model trained on multiple handwriting styles instead of using a separate model for every language. When successful, this approach allows us to automate the transcription of the archive, reducing manual annotation efforts and facilitating information retrieval. To train the model, we used the material from the personal archive of the Dutch glass artist Sybren Valkema (1916–1996), processing it with Transkribus.
The Roles of Calcineurin B-like Proteins in Plants under Salt Stress
Authors: Hunpatin Oluwaseyi Setonji , Yuan Guang , Nong Tongjia , Shi Chuhan , Wu Xue , Liu Haobao , Ning Yang , Wang Qian
Published: November 2023

Salinity stands as a significant environmental stressor, severely impacting crop productivity. Plants exposed to salt stress undergo physiological alterations that influence their growth and development. Meanwhile, plants have also evolved mechanisms to endure the detrimental effects of salinity-induced salt stress. Within plants, Calcineurin B-like (CBL) proteins act as vital Ca2+ sensors, binding to Ca2+ and subsequently transmitting signals to downstream response pathways. CBLs engage with CBL-interacting protein kinases (CIPKs), forming complexes that regulate a multitude of plant growth and developmental processes, notably ion homeostasis in response to salinity conditions. This review introduces the repercussions of salt stress, including osmotic stress, diminished photosynthesis, and oxidative damage. It also explores how CBLs modulate the response to salt stress in plants, outlining the functions of the CBL-CIPK modules involved. Comprehending the mechanisms through which CBL proteins mediate salt tolerance can accelerate the development of cultivars resistant to salinity.
OTX Genes in Adult Tissues
Authors: Terrinoni Alessandro , Micheloni Giovanni , Moretti Vittoria , Caporali Sabrina , Bernardini Sergio , Minieri Marilena , Pieri Massimo , Giaroni Cristina , Acquati Francesco , Costantino Lucy , Ferrara Fulvio , Valli Roberto , Porta Giovanni
Published: November 2023

OTX homeobox genes have been extensively studied for their role in development, especially in neuroectoderm formation. Recently, their expression has also been reported in adult physiological and pathological tissues, including retina, mammary and pituitary glands, sinonasal mucosa, in several types of cancer, and in response to inflammatory, ischemic, and hypoxic stimuli. Reactivation of OTX genes in adult tissues supports the notion of the evolutionary amplification of functions of genes by varying their temporal expression, with the selection of homeobox genes from the “toolbox” to drive or contribute to different processes at different stages of life. OTX involvement in pathologies points toward these genes as potential diagnostic and/or prognostic markers as well as possible therapeutic targets.