bluuebunny/crossref_metadata_2025 huggingface dataset:
Prescriber Attitudes and Medication Assisted Treatment
Authors: A. Hereford, MSPH, MSW Courtney , Lyon, MD Jacob , Montalto, DO Norman , Becker, MD James , H. Davies, PhD Todd
Published: April 2023

INTRODUCTION Increases in opioid use disorder (OUD) and the consequences to communities across the United States have resulted in a call for an increase in buprenorphine-based medication-assisted treatment (MAT) options. As legislative efforts continue to expand, it is important to understand the provider viewpoint of any such expansion. METHODS An anonymous survey was conducted in 2019 among primary care physicians, specialists, and mid-level practitioners, as well as dentists, op-tometrists, veterinarians, and providers currently practicing in West Virginia (WV) and eligible to prescribe opioids and scheduled substances. The survey included both quantitative and qualitative items measuring provider self-reported practices, training, support, experiences, and perceptions on treatment of patients using MAT. RESULTS A significant (p<0.001) majority of providers reported the need for MAT expansion and the belief that patients with OUD benefit from MAT (2.7% response rate). Despite this acknowledged need and established efficacy of MAT, survey findings suggest that fewer providers in WV seem interested or willing to expand their practice by providing MAT without additional resources and support. DISCUSSION Despite a small response rate, the participants responses provide useful information. While recent legislation efforts to encourage expansion of treatment waivers and access have been successful, providers reported significant barriers to expanding or incorporating MAT into their practices. Current MAT practitioners report institutional and staff support as major factors in their willingness to provide MAT. The critical question remains on how best to incentivize and sustain MAT practice and remove barriers for providers to meet the growing need and improve care.
Tuberculosis Presenting as Intestinal Granulomas in a Patient from West Virginia
Authors: Catherman, MD Kristen , Deepak, MD Vishal , Balakrishnan, MD Bathmapriya , Al-Jaroushi,MD Hatim
Published: April 2023

uberculosis (TB) is relatively uncommon in West Virginia compared to surrounding Appalachia and the rest of the country. Despite the low prevalence, it is essential to diagnose promptly given the high potential for significant disease burden. Miliary TB is a form of disseminated Mycobacterium tuberculosis infection resulting from hematogenous spread of the organism. Known risk factors for developing disseminated TB include immunosup-pressant medications, human immunodeficiency virus infection, and extremes of age. We present a case in which a patient without identifiable risk factors for TB developed intestinal TB that had been misdiagnosed as Crohn's disease. Shortly after being started on immunosuppressant therapy for the presumed inflammatory bowel disease, the patient developed significant miliary TB
Assessment of Crop Production Dynamics in Punjab
Authors: RALTE ROHLUPUII , KAUR ARJINDER , KATARIA POONAM , PRISCILLA LAISHRAM
Published: April 2023

The structural transformation brings changes to new technology in the form of high-yielding seeds, fertilizers and pesticides and the adoption of modern and improved farm practices since mid-1960s. However, after the mid-1980s, the growth rate of the agricultural economy started decelerating. Results revealed that during overall period, the growth rate in area, production and yield was negative for field crops except for rice and wheat. For fruits and vegetables, the growth rate in area, production and yield were positive for almost all the periods, the area effect was higher for food grains and the yield effect was higher in fruits. The state was found to be less diversified.
The Effectiveness of Online-Only Blended Cardiopulmonary Resuscitation Training: Static-Group Comparison Study
Authors: Chong Kah Meng , Yang Hsiang-Wen , He Hsien-Chin , Lien Wan-Ching , Yang Mei-Fen , Chi Chien-Yu , Chen Yen-Pin , Huang Chien-Hua , Ko Patrick Chow-In
Published: April 2023

Background

Basic life support (BLS) education is essential for improving bystander cardiopulmonary resuscitation (CPR) rates, but the imparting of such education faces obstacles during the outbreak of emerging infectious diseases, such as COVID-19. When face-to-face teaching is limited, distance learning—blended learning (BL) or an online-only model—is encouraged. However, evidence regarding the effect of online-only CPR training is scarce, and comparative studies on classroom-based BL (CBL) are lacking. While other strategies have recommended self-directed learning and deliberate practice to enhance CPR education, no previous studies have incorporated all of these instructional methods into a BLS course.

Objective

This study aimed to demonstrate a novel BLS training model—remote practice BL (RBL)—and compare its educational outcomes with those of the conventional CBL model.

Methods

A static-group comparison study was conducted. It included RBL and CBL courses that shared the same paradigm, comprising online lectures, a deliberate practice session with Little Anne quality CPR (QCPR) manikin feedback, and a final assessment session. In the main intervention, the RBL group was required to perform distant self-directed deliberate practice and complete the final assessment via an online video conference. Manikin-rated CPR scores were measured as the primary outcome; the number of retakes of the final examination was the secondary outcome.

Results

A total of 52 and 104 participants from the RBL and CBL groups, respectively, were eligible for data analysis. A comparison of the 2 groups revealed that there were more women in the RBL group than the CBL group (36/52, 69.2% vs 51/104, 49%, respectively; P=.02). After adjustment, there were no significant differences in scores for QCPR release (96.9 vs 96.4, respectively; P=.61), QCPR depth (99.2 vs 99.5, respectively; P=.27), or QCPR rate (94.9 vs 95.5, respectively; P=.83). The RBL group spent more days practicing before the final assessment (12.4 vs 8.9 days, respectively; P<.001) and also had a higher number of retakes (1.4 vs 1.1 times, respectively; P<.001).

Conclusions

We developed a remote practice BL–based method for online-only distant BLS CPR training. In terms of CPR performance, using remote self-directed deliberate practice was not inferior to the conventional classroom-based instructor-led method, although it tended to take more time to achieve the same effect.

Trial Registration

Not applicable.
Six Practical Strategies to Mentor and Sponsor Women in Academic Medicine (Preprint)
Authors: Silver Julie K
Published: April 2023

UNSTRUCTURED

This article focuses on the importance of mentorship and sponsorship for women in academic medicine, including trainees and faculty, and emphasizes the need for flexible and expanded definitions. Both the benefits and potential harms associated with sponsorship are described. There are 6 actionable strategies illustrated that may be added to a multidimensional mentoring model in order to better support women in medicine.
Applications of Epipelic Diatoms and Probiotics for Pacific White Shrimp Nursery (Litopenaeus vannamei)
Authors: Wardi Wardi , Sektiana Sinar Pagi , Suprakto Bambang
Published: April 2023

Pacific white shrimp (Litopennaeus vannamei) is a type of shrimp that is very easy to cultivate because it has several advantages, it is resistant to disease and has a high survival rate, and productivity can reach 13.6 tons/ha. Very high density because it can use feed and space more efficiently. This is what makes many farmers in Indonesia cultivate it. Despite the many advantages, there are still many obstacles faced by cultivators who experience failure and losses. The failure was caused by poor water quality during cuture and the emergence of disease attacks that caused slow growth decreased production and resulted in huge losses for farmers. To overcome these problems, it is necessary to improve the water quality of the cultivation media used. Water quality improvement was carried out by the application of probiotics for the vannamei nursery. The purpose of this study was to evaluate the optimal dose/cell count on water quality and shrimp growth and evaluate the developmental level of pathogenic bacteria treated with Epipelic Diatoms (DE) and Probiotic. The method used was an experimental method using a completely randomized design (CRD) with 4 treatments and 3 replications. The treatments tested were A (pure seawater), B (100% DE), C (100% PB), D (100% DE+100% PB). The seeds used were PL 6 vannamei shrimp with an average weight of 0.175 g and an average length of 5.5. The results showed that the combination of DE and PB had a significant effect (p<0.05) on water quality and the growth and survival of post-vannamei larvae.
Evaluation of the Performance Improvement of the Muara Angke Nusantara Fishing Port (NFP), Jakarta
Authors: Nurazizah Khairunnisa , Suherman Agus , Fitri Aristi Dian Purnama
Published: April 2023

Fishing ports play an important role in facilitating fishing business activities and supporting fish resource management. The completion of facilities at fishing ports will aid in the continuation of fishing business operations. As a Fishing Port, the Muara Angke Nusantara Fishing Port must provide good services and respond to the needs of the Muara Angke fishery community, particularly for supporting industry in Jakarta. Therefore, the facilities of Muara Angke Nusantara Fishing Port must be evaluated (NFP). The study aimed to analyze the facilities at Muara Angke Nusantara Fishing Port to improve their performance by analyzing the conditions of the fishing port facilities, the level of utilization of the facilities, and the strategy for developing fishing ports with SWOT analysis so that they can contribute to supporting activities and the fishing industry in Jakarta. This research was carried out at the Muara Angke Fishing Port in July 2022. The study used a descriptive method. A purposive sampling method was used to collect data from 50 fishery business actors at the Muara Angke Fishing Port. The facility score was 2.5, indicating that the facilities at the Nusantara Fishery Port were good, but the level of utilization was low due to the length of the pier, the area of the pond, the depth of the harbor pool, and the utilization rate of the fish auction. The SWOT analysis indicated that the X; Y results were 0.12 and 0.54 which were located in quadrant I or the S-O (Strength-Opportunity) strategy. As a result, to increase the facility utilization rate score, the Muara Angke Archipelago Fishery Port (PPN) must improve services and attract investors.
Effect of Extract Euphorbia hirta Linn. Against Leaf and Fruit Pests on Plants Cucumber (Cucumis sativus Linn.)
Authors: Rahmah Aulia
Published: April 2023

Euphorbia hirta which is commonly known as "patikan kebo" is small herb which gives milky latex. This study aims to determine the effect of E. hirta extract in reducing the intensity of leaf and fruit pest attacks on cucumber plants Cucumis sativus Linn. The results of this study showed that all treatments with this extract were able to suppress the intensity of pest attacks on cucumber plants and had a significant effect on reducing the intensity of pest attacks on cucumber plants. The best concentration that can reduce the intensity of these pest attacks is the treatment of 10% can reduce the intensity of leaf pest attacks on cucumber plants up to 4.64%. The intensity of pest attacks on cucumbers only occurred in the control and 2% extract treatment with percentages of damage intensity to cucumbers of 9.38% and 3.13%.
A Cloud-Based AI Way to deal with Phishing URL Location
Authors: K Gomathi
Published: April 2023

Abstract: Phishing is constantly growing to be one of the most adopted tools for conducting cyber-attacks. Recent statistics indicated that 97% of users could not recognize a sophisticated phishing email. With over 1.5 million new phishing websites being created every month, legacy black lists and rule-based filters can no longer mitigate the increasing risks and sophistication level of phishing. Phishing can deploy various malicious payloads that compromise the network’s security. In this context, machine learning can play a crucial role in adapting the capabilities of computer networks to recognize current and evolving phishing patterns. In this paper, we present PhishNot, a phishing URL detection system based on machine learning. Hence, our work uses a primarily ”learning from data” driven approach, validated with a representative scenario and dataset. The input features were reduced to 14 to assure the system’s practical applicability. Experiments showed that Random Forest presented the best performance with a very high accuracy of 97.5%. Furthermore, the design of our system also lends itself to being more adoptable in practice through a combination of high phishing detection rate and high speed (an average of 11.5 per URL) when deployed on the cloud
Screen Pseudo-Slant Lightlike Submersions
Authors: Shukla S. S. , Omar Shivam
Published: April 2023

In this article, we introduce the notion of screen pseudo-slant lightlike submersions from an indefinite Kähler manifold onto a lightlike manifold which includes complex (invariant), screen real (anti-invariant), screen slant and SCR lightlike submersions. We study some properties of proper screen pseudo-slant lightlike submersions with non-trivial examples and gave a characterization theorem. We also obtain integrability conditions of distributions involved in the definition of such submersions.
Book review: The economic situation of the rural population of the Zаkazany’e (19th – early 20th century): collection of documents and materials (Kazan, 2022)
Authors: Koreeva Natalya Anatolyevna
Published: April 2023

The review describes the content of the collection of documents intended to study the economic situation of the rural population of the Zаkazany’e in the 19th – early 20th century. The review examines such problems as scientific relevance, practical significance (relevance) of the collection's documentary corpus from a historiographical perspective. Some shortcomings of the archeographic design of published documents are noted – in the preparation of headings and reference information about documents.
ANALISIS PENDAPATAN DAN KELAYAKAN USAHATANI CENGKEH DI DESA SILAMPAYANG KECAMATAN KASIMBAR KABUPATEN PARIGI MOUTONG
Authors: Marzuki Nur Fadillah , Effendy Effendy , Hatmi Wira
Published: April 2023

Penelitian ini bertujuan untuk mengetahui pendapatan dan kelayakan usahatani cengkeh di Desa Silampayang Kecamatan Kasimbar Kabupaten Parigi Moutong. Penelitian ini dilaksanakan pada bulan Maret sampai dengan Mei 2022. Responden pada penelitian ini sebanyak 30 dengan jumlah populasi petani cengkeh

sebanyak 90 orang. Pada penelitian ini menunjukkan bahwa penerimaan petani cengkeh rata-rata sebesar Rp. 31.566.131/Ha/Tahun, rata-rata total biaya adalah Rp. 11.967.787/Ha/Tahun, maka rata-rata pendapatan petani cengkeh adalah Rp. 19.598.344/Ha/Tahun. Pada kelayakan usahatani cengkeh adalah R/C = 2,63

artinya usahatani cengkeh tersebut layak diusahakan oleh petani, mengingat R/C Ratio lebih besar dari 1, dimana nilai tersebut menunjukkan total penerimaan lebih besar dari total biaya-biaya yang dikeluarkan oleh petani cengkeh di Desa Silampayang Kecamatan Kasimbar Kabupaten Parigi Moutong.
ANALISIS PENENTUAN HARGA POKOK PRODUKSI PADA INDUSTRI TAHU KAROMA DI KOTA PALU
Authors: Julianto Wayan Nova , Antara Made , Wibawa I Gede Laksana
Published: April 2023

Tujuan penelitian ini yaitu ingin mengetahui berapa harga pokok produksi menggunakan metode full costing dan variable costing pada industri tahu karoma di kota palu. Penelitian ini dilaksanakan di industri Tahu Karomah yang terletak di Kota Palu pada bulan Juli 2022.Penentuan Responden dilakukan secara sengaja (Purposive), dengan jumlah responden sebanyak 3 (tiga) orang yakni, pimpinan industri dan dua orang karyawan bagian produksi Industri Tahu Karoma. Penelitian ini menggunakan data primer dan data sekunder, sedangkan alat analisis yang digunakan adalah analisis penentuan harga pokok produksi

menggunakan metode full costing dan variable costing. Hasil penelitian ini menunjukan harga pokok produksi menurut perusahan Industri Tahu Karoma sebesar Rp93.000.000,- dengan harga pokok pokok per satuanRp3.800,- dan harga pokok produksi dengan metode full costingsebesar Rp96.076.850,- dengan harga pokok produksi per kg sebesar Rp3.912,-/kg. Sedangkan harga pokok produksi dengan metode variable costing sebesar Rp87.906.000,- dan Harga pokok Produksi per Kg sebesar Rp3.588,-/kg. selisih harga pokok produksi dengan menggunakan metode full costing dan menurut perusahan sebesar Rp. 3.076.450,- dengan selisih harga pokok produksi per satuan sebesar Rp 121/Kg,-. Selisih penghitungan pokok produksi menurut perusahaan dan menurut metode variable costing untuk produksi tahu di Industri Tahu Karoma yaitu sebesar Rp 5.094.000,- dengan selisih harga pokok produksi per satuan yaitu sebesar Rp 212/kg,-.
STRATEGI PENGEMBANGAN DURIAN MONTONG KUPAS PADA INDUSTRI SILVIA JAYA DI DESA TOLAI KECAMATAN TORUE
Authors: Ganata I Gede Giri , Asih Dewi Nur , Hatmi Wira
Published: April 2023

Penelitian ini bertujuan mengetahui strategi pengembangan durian montong kupas pada industri Silvia Jaya di Desa Tolai Kecamatan Torue. Penelitian dilaksanakan di industri Silvia Jaya pada bulan Mei-Agustus 2022, penentuan responden dilakukan secara sengaja (Purposive), dengan jumlah responden sebanyak 9 orang yaitu pimpinan industri, 3 orang karyawan tetap, 2 orang pesaing industri, 2 orang konsumen akhir dan 1 orang penyedia modal. Analisis yang digunakan adalah

analisis SWOT. Hasil penelitian menunjukan berdasarkan hasil perhitungan IFAS didapatkan hasil kondisi internal CV. Silvia Jaya diperoleh hasil pengurangan dari total skor faktor kekuatan dan total skor faktor kelemahan sebagai sumbu X yaitu sebesar 1,10, sedangkan pada hasil perhitungan EFAS didapatkan hasil kondisi eksternal CV. Silvia Jaya diperoleh hasil pengurangan dari total skor faktor peluang dan total skor faktor acaman sebagai sumbu Y yaitu sebesar 1,26. Alternatif strategi yang dapat diterapkan dalam Strategi Pengembangan Durian Montong Kupas Pada Industri Silvia Jaya di Desa Tolai Kecamatan Torue adalah strategi S-O. 1. Memanfaatkan pengalaman ber-usaha dalam mengelola usaha untuk memperoleh harga jual yang mahal. 2. Memanfaatkan kualitas produk danproduk tanpa pengawet untuk merebut pasar seluas-luasnya. 3. Memanfaatkan permintaan tinggi dan memanfaatkan berkembangnya media promosi guna memperoleh konsumen baru.
Bifurcation analysis of a reaction-diffusion-advection predator-prey system with delay
Authors: Duan Daifeng , Bin Honghua , Wei Junjie
Published: April 2023

A diffusive predator-prey system with time delay and advection is
considered. By regarding the conversion delay τ as a main
bifurcation parameter, we show that Hopf bifurcation occurs when the
parameter τ varies. Then by the improved normal form theory and
the center manifold theorem for partial functional differential
equations, an algorithm for determining the direction and the stability
of Hopf bifurcation is derived. Finally, some numerical simulations are
carried out for illustration of the theoretical results.
Follow-up and comparative assessment of SARS-CoV-2 IgA, IgG, neutralizing, and total antibody responses after BNT162b2 or mRNA-1273 heterologous booster vaccination
Authors: Younes Salma , Nicolai Eleonora , Pieri Massimo , Bernardini Sergio , Al-Sadeq Duaa , Younes Nadin , Shurrab Farah , Nizamuddin Parveen , Humaira Fathima , Al-Dewik Nader , Yassine Hadi , Abu-Raddad Laith , Ismail Ahmed , Nasrallah Gheyath
Published: April 2023

Background: Priming with ChAdOx1 followed by heterologous boosting have
been considered in several countries. Nevertheless, analyses that
provide a comparison of the immunogenicity of heterologous booster in
comparison to homologous primary vaccination regimens and natural
infection are lacking. In this study, we aimed to conduct a comparative
assessment of the immunogenicity between heterologous prime-boost
vaccination using BNT162b2 or mRNA-1273 and homologous primary
vaccination regimens. Methods: We matched vaccinated naïve individuals
(VN; n=673) who had received partial vaccination (n=64), primary
vaccination (n=590), or primary series plus one mRNA vaccine
heterologous booster (n=19) with individuals with a documented primary
SARS-CoV-2 infection and no vaccination record (natural infection; NI
cohort; n=206). We measured the levels of neutralizing total antibodies
(NTAbs), total antibodies (TAbs), anti-S-RBD IgG, and anti-S1 IgA
titers. Results: Homologous primary vaccination with ChAdOx1 not only
showed less potent NTAb, TAb, anti-S-RBD IgG, and anti-S1 IgA immune
responses compared to primary-BNT162b2 or mRNA-1273 vaccination regimens
(P<0.05), but also showed ~3 fold less anti-S1
IgA response compared to infection-induced immunity (P<0.001).
Nevertheless, heterologous booster dose resulted in a significant boost
of at least ~12 folds in the immune response.
Furthermore, correlation analyses revealed that both, anti-S-RBD IgG and
anti-S1 IgA significantly contributed to virus neutralization among NI
individuals, particularly in symptomatic and pauci-symptomatic
individuals, whereas, among VN individuals, anti-S-RBD IgG was the main
contributor to virus neutralization (r > 0.90, P
< 0.001). Conclusion: The results emphasize the potential
benefit of using heterologous mRNA boosters to increase antibody levels
and neutralizing capacity.
CONFRONTING COVID-19 PANDEMIC - PAKISTAN'S EXPERIENCE WITH LABORATORY DETECTION
Authors: Salman Muhammad , Ikram Aamer , Badar Nazish , Tahir Faheem , Umair Massab , Ahad Abdul
Published: April 2023

COVID-19 pandemic has affected all countries and has threatened not only
the health systems but overall governance structure of countries across
the globe. Countries with weak public health systems remained at risk of
substantial morbidity and mortality due to COVID-19. In Pakistan, due to
diversity in provincial public health preparedness capacities SARS-CoV-2
data collection and response was fragmented during the early phase of
the pandemic. To overcome this, the National CommandOperation Center
(NCOC) was established in March 2020 and has been now merged with NIH.
As of 7th February 2023, 1.6 million people have been infected with
COVID-19, with over 30 thousand deaths reported across the country. NIH
delivered awareness lectures on national media, point of entry,
hospitals, and public institutes, and conducted vaccination companies,
rapid response, surveillance, and diagnostics facilities at point of
entry. NIH provided leadership for enhancing the COVID-19 testing
capacities after acquiring SARS-CoV-2 detection capability in Feb 2020.
NIH-mandated training on bio risk management, SARS-CoV-2 diagnostics,
and laboratory assessment for a number of provincial public and private
laboratories. Besides developing national guidelines for testing and
strategies for molecular and antigen-based testing, the institute also
leads genomic surveillance for SARS-CoV-2 covering all waves of
SARS-CoV-2 pandemic which has subsequently revealed early detection of
variants of concerns (VOCs). The NIH has submitted 3360 SARS-CoV-2
sequences to the GISAIDdatabase and organized an external quality
assessment (EQA) of molecular detection of SARS-CoV-2 by distributing an
EQA panel to public and private laboratories.
Soil salinity estimation based on machine learning using the GF-3 radar and Landsat-8 data in the Keriya Oasis, Southern Xinjiang, China
Authors: Xiao Sentian , Nurmemet Ilyas , Muhetaer Nuerbiye , Zhao Jing , Abulaiti Adilai
Published: April 2023

Soil salinization has been an important environmental problem globally,
particularly in oasis areas in arid zones. The advantages of using
multi-source data, combining radar and optical remote sensing data, and
applying machine learning-based algorithms to these data could be
beneficial for addressing the soil salinization problem. The current
research on salinity estimation still needs to be deepened. To overcome
this shortcoming, this study combines the environmental covariates
extracted from the Gaofen-3 (GF-3) radar data, Landsat-8 multispectral
data, and digital elevation model (DEM) data to explore the advantages
of radar remote sensing in detecting soil salinity. The soil salinity
distribution degree in the Keriya Oasis is mapped using a
machine-learning-based method, and the advantages of different sensor
images in predicting soil salinity are evaluated. Three soil salinity
inversion models are constructed using measured electrical conductivity
(EC) data, the random forest (RF), gradient boosting tree (GDBT), and
extreme gradient boosting (XGBoost) models. Also, five classes of
optimal environmental covariates are used. The results show that the
best accuracy corresponding to an R of 0.87, a root
mean square error (RMSE) of 6.02, and a relative percent deviation (RPD)
of 2.77 is achieved by the RF model on the GF-3+Landsat-8 data.
Therefore, using multi-source data can fully exploit the advantages of
both radar and optical data and has been demonstrated to be a more
effective method for mapping soil salinity in the study area. In the
importance analysis of independent variables, the salinity index (SI),
normalized difference vegetation index (NDVI), and DEM contributed the
most to the prediction of soil salinity. In this study, the radar
polarization decomposition characteristics are incorporated into the
inversion of soil salinity modeling as an environmental covariate,
providing an innovative and efficient method for soil salinity
estimation in arid areas.
Terrain-derived measures for basin conservation/restoration planning
Authors: Matt Jeremy E. , Underwood Kristen L. , Diehl Rebecca M. , Lawson K.S. , Worley Lindsay C. , Rizzo Donna M.
Published: April 2023

Centuries of human development have altered the connectivity of rivers,
adversely impacting ecosystems and the services provided. Significant
investments in natural resource projects are made annually with the goal
to restore function to degraded rivers and floodplains and protect
freshwater resources. Yet restoration projects often fall short of their
objectives, in part, due to the lack of systems-based, strategic
planning. To evaluate channel-floodplain (dis)connectivity and
erosion/incision hazard at the regional scale, we calculate Specific
Stream Power (SSP), an estimate of the energy of a river, using a
topographically-based, low-complexity hydraulic model. Other basin-wide
SSP modeling approaches neglect reach-specific geometric information
embedded in Digital Elevation Models. Our approach leverages this
information to generate reach-specific SSP-flow curves. We extract
measures from these curves that describe (dis)connected floodwater
storage capacity and erosion hazard at individual design storm flood
stages and demonstrate how these measures may be used to identify
watershed-scale patterns in connectivity. We show proof-of-concept using
25 reaches in the Mad River watershed in central Vermont and demonstrate
that the SSP results have acceptable agreement with a well-calibrated
process-based model (2D Hydraulic Engineering Center’s River Analysis
System) across a broad range of design events. While systems-based
planning of regional restoration and conservation activities has been
limited largely due to computational and human resource requirements,
measures derived from low complexity models can provide an overview of
reach-scale conditions at the regional level and aid planners in
identifying areas for further restoration and/or conservation
assessments.
Strain-specific metabarcoding reveals rapid evolution of copper tolerance in populations of the coastal diatom Skeletonema marinoi
Authors: Andersson Björn , Berglund Olof , Filipsson Helena , Kourtchenko Olga , Godhe Anna , Johannesson Kerstin , Töpel Mats , Pinder Matthew , Hoepfner Lara , Rengefors Karin
Published: April 2023

Phytoplankton have short generation times, flexible reproduction
strategies, large population sizes, and high standing genetic diversity,
traits that should facilitate rapid evolution under directional
selection. We quantified local adaptation of copper tolerance in a
population of the diatom Skeletonema marinoi from a mining exposed inlet
in the Baltic Sea and in a non-exposed population 100 km away. We
hypothesized that mining pollution has driven evolution of elevated
copper tolerance in the impacted population of S. marinoi. Assays of 58
strains originating from sediment resting stages revealed no difference
in the average tolerance to copper between the two populations. However,
variation within populations was greater at the mining site, with three
strains displaying hyper-tolerant phenotypes. In an artificial evolution
experiment, we used a novel intraspecific metabarcoding locus to track
selection and quantify fitness of all 58 strains during co-cultivation
in one control and one toxic copper treatment. As expected, the
hyper-tolerant strains enabled rapid evolution of copper tolerance in
the mining exposed population through selection on available strain
diversity. Within 42 days, in each experimental replicate a single
strain dominated (30-99% abundance) but different strains dominated the
different treatments. The reference population developed tolerance
beyond expectations primarily due to slowly developing plastic response
in one strain, suggesting that different modes of copper tolerance are
present in the two populations. Our findings provide novel empirical
evidence that standing genetic diversity of phytoplankton resting stage
allows populations to evolve rapidly (20-50 generations) and flexibly on
timescales relevant for seasonal bloom progressions.
The Natural History of Pelizaeus-Merzbacher Disease
Authors: Trepanier Angela , Aguilar Sienna , Kamholz John , Laukka Jeremy
Published: April 2023

AbstractObjective The objective of this study was to
characterize the clinical features, developmental milestones, and the
natural history of Pelizaeus Merzbacher disease (PMD) associated with
PLP1 gene duplications. Methods The study examined 16 PMD
Patients ranging in age from 7 to 48, who had a documented PLP1
gene duplication. The
Economic synthesis of highly dispersed amorphous silicon dioxide from technogenic wastes and its textural properties
Authors: Kurbanov M.Sh. , Andriyko L.S. , Panjiev J.A. , Tulaganov S.A. , Gun'ko V.M. , Marynin A.I. , Pikus S.
Published: April 2023

A new pilot plant equipment with application of the ammonium fluorine
technology for processing silicon-containing raw materials using the
physical effects of sublimation and desublimation has been developed and
manufactured. It is shown that the usage of the created device for the
processing of metallurgical waste makes it possible to separate
amorphous silicon dioxide in the form of a dispersed powder from slags,
extract iron oxide and obtain a collective concentrate of valuable
components. The synthesized silicas have been studied by inductively
coupled plasma (ICP) mass-spectrometry, scanning electron microscopy,
X-ray diffraction, small angle X-ray scattering, laser correlation
spectroscopy, and low-temperature nitrogen adsorption-desorption
analysis. It has been shown that an increase in hexafluorosilicate
concentration by 10 times during the silicon dioxide synthesis led to
increasing effective diameter of silica particles more than four times,
and a decrease in the SiO yield by ~25
%. The silica samples have amorphous structure and purity ≥ 99.97 %.
The specific surface area (S ) is equal to 64 m
/g for silica synthesized using copper melting slag
and S = 10 m /g for silica
synthesized from microsilica prepared using ferrosilicon production
waste. The total pore volume is 0.22 cm /g and 0.08
cm /g for these silica samples, respectively. There
is a fraction of pores inaccessible (closed) for nitrogen molecules that
can be detected with the SAXS method since there is a relation S
> S . Thus, the use
of waste from metallurgical industries allows one to implement a
resource-saving technology for producing highly disperse silica with
appropriate textural characteristics.
RECOMBINANT HUMAN MONOCLONAL ANTIBODIES CASIRIVIMAB/IMDEVIMAB USE IN INHIBITION OF THE SARS-CoV-2 VIRUS INFECTION
Authors: Beliančinová Monika , Kleinová Patrícia , Vnučák Matej , Graňák Karol , Kolorz Michal , Mokáň Marián , Dedinská Ivana
Published: April 2023

Introduction: The spread of the SARS-CoV-2 virus has caused severe
problems for healthcare facilities and infrastructure worldwide. The
development of rapid diagnostic tools, effective treatment protocols,
and vaccines against the pathogen has accelerated. This work aims to
elucidate the benefits of recombinant human monoclonal antibodies to
slow the progression of SARS-CoV-2 variant B.1.617.2 infection (delta
variant). Material and methods: This is a retrospective analysis with a
6-month follow-up involving all patients who received recombinant human
monoclonal antibodies (MABs) casirivimab/ imdevimab at University
Hospital Martin in November and December of 2021. Results: A total of
180 patients were enrolled in the cohort with a mean time to
administration of symptoms were 6,01 +/-0,3 days in the group of
vaccinated patients and 5,52+/-0,28 days in the group of non-vaccinated
patients and a mean time to the resolution of symptoms were 4,37 +/-0,62
days in the group of vaccinated patients and 3,83 +/-0,3 days in the
group with non-vaccinated patients. Of these patients, 13 developed
bronchopneumonia (7,2%)—serious side effects after MAB administration
were observed in 1 patient. Conclusion: Using recombinant human
monoclonal antibodies casirivimab/ imdevimab to slow or to stop
SARS-CoV-2 variant infection B.1.617.2 significantly affected the course
of the disease. Quick diagnostics, identification of at-risk patients,
and multidisciplinary collaboration are essential in COVID-19
management.
Plasma insulin concentration in newborns and children and age at menarche
Authors: Wang Guoying , Radovick Sally , Buckley Jessie P. , Hauser Russ , Williams Paige L. , Hong Xiumei , PEARSON COLLEEN , Adams William G. , Wang Xiaobin
Published: April 2023

  

OBJECTIVE: To investigate the association of plasma insulin levels and their trajectories from birth to childhood with the timing of menarche. 

RESEARCH DESIGN AND METHODS: This prospective study included 458 girls recruited at birth between 1998 and 2011 and followed prospectively at the Boston Medical Center. Plasma non-fasting insulin concentrations were measured at two time points: at birth (cord blood) and in childhood (age 0.5-5 years). Age at menarche was obtained from a pubertal developmental questionnaire or abstracted from electronic medical records. 

RESULTS: 306 (67%) of the girls had reached menarche. The median (range) age at menarche was 12.4 (9-15) years. Elevated plasma insulin concentrations at birth (n=391) and in childhood (n=335) were each associated with an earlier mean age at menarche: approximately 2 months earlier per doubling of insulin concentration (mean shift, -1.95 months, 95%CI, -0.33 to -3.53 and -2.07 months, 95%CI, -0.48 to -3.65), respectively. Girls with overweight or obesity in addition to elevated insulin attained menarche about 11-17 months earlier on average than those with normal weight and low insulin. Considering longitudinal trajectories (n=268), having high insulin levels at both birth and childhood was associated with a roughly 6 months earlier mean age at menarche (mean shift, -6.25 months, 95%CI, -0.38 to -11.88), compared with having consistently low insulin levels at both timepoints. 

CONCLUSIONS: Our data showed that elevated insulin concentrations in early life, especially in conjunction with overweight or obesity, contribute to the earlier onset of menarche, suggesting the need for early screening and intervention. 
Safe Usage of Isotretinoin in a Woman with Latent Acute Intermittent Porphyria
Authors: Storjord Elin , Brekke Ole-Lars , Waage Nielsen Erik
Published: April 2023

This article does not have an abstract.
Polypoid Basal Cell Carcinoma as a New Variant of Basal Cell Carcinoma: Three Korean Cases
Authors: Choi Jae Eun , Ko Na Young , Seo Soo Hong , Kim Soo Nam , Kye Young Chul , Ahn Hyo Hyun
Published: April 2023

This article does not have an abstract.
Bullous Pilomatricoma: A Particular and Rare Dermal Bullous Disorder
Authors: De Giorgi Vincenzo , Alfaioli Barbara , Massi Daniela , Gori Alessia , Sestini Serena , Papi Federica , Grazzini Marta , Lotti Torello
Published: April 2023

This article does not have an abstract.
Skin Nodules in Rheumatoid Arthritis Due to Infection with Mycobacterium haemophilum
Authors: Seitz Cornelia S. , Trautemann Axel , Bröcker Eva-Bettina , Abele-Horn Marianne , Goebeler Matthias
Published: April 2023

This article does not have an abstract.
Beneficial and Rapid Effect of Infliximab on the Course of Toxic Epidermal Necrolysis
Authors: Wojtkiewicz Agnieszka , Wysocki Mariusz , Fortuna Jacek , Chrupek Malgorzata , Matczuk Maciej , Koltan Andrzej
Published: April 2023

This article does not have an abstract.
Commentary to a Paper by Flosadøttir & Bjarnason on Full Dapsone Dose Made Possible by Control of Anaemia with Darbepoetin-alpha
Authors: Mobacken Håkan
Published: April 2023

This article does not have an abstract
Borderline Lepromatous Leprosy Presenting as a Single Cutaneous Plaque
Authors: Maejima Hideki , Ishii Norihisa , Aki Ryouichi , Katsuoka Kensei , Obata Shuichi
Published: April 2023

This article does not have an abstract.
Abstracts from the 9th World Congress of Itch
Authors: Listed No authors
Published: April 2023

Abstracts
An Integrated RME and PIL Mathematics Module for Technical Vocational High School Learning: A Need Analysis
Authors: Rejeki Sri , Adnan Mazlini , Che Ahmad Che Nidzam , Murtiyasa Budi
Published: April 2023

Text-based learning resources play an essential role in supporting students’ mathematics learning. However, there are still limited studies about developing mathematics modules as one of text-based learning resources for Technical Vocational High School (TVHS) students. Therefore, this study investigates the need to develop an integrated Realistic Mathematics Education (RME) and Project-based Inquiry Learning (PIL) mathematics module for TVHS learning. This study is a descriptive survey involving 66 tenth grade TVHS students and 21 TVHS mathematics teachers in a sub-urban area of Central Java, Indonesia. Moreover, it also involves ten mathematics lecturers who teach “teaching mathematics for secondary school learning” courses from public and private universities in Indonesia. The data collection was conducted using printed questionnaires (for students) and online questionnaires (for teachers and lecturers). The data was summarized and analyzed descriptively. Based on the data analysis, it can be concluded that there are still limited realistic problems in Indonesian mathematics textbooks for TVHS students. Therefore, developing an integrated RME and PIL mathematics module is necessary. The characteristics of the integrated RME and PIL mathematics module are: (1) The module’s content should be presented in Bahasa Indonesia, providing realistic contexts by the area of expertise of the TVHS students and contexts across fields; (2) The learning activities should be carried out in groups, inside classrooms, involves creating projects not only by the area of expertise of the TVHS students, and the project results are displayed directly in an exhibition gallery; (3) The learning media can use both manual and Information and Communication Technology (ICT)-based tools; (4) The assessment can be conducted in both written and authentic assessments.
Features of reactivity of the EEG mu rhythm in children with autism spectrum disorders in helping behavior situations
Authors: Pavlenko VB , Kaida AI , Klinkov VN , Mikhailova AA , Orekhova LS , Portugalskaya AA
Published: April 2023

One of the subjects being discussed by the professional community currently is the role possibly played by the mirror neuron system (MNS) in the violation of social behavior of children with autism spectrum disorders (ASD). The MNS is known to shape the perception of emotions of others and understanding and imitation of their actions. Mu rhythm desynchronization in EEG is considered to be the indicator of the MNS activation. The purpose of this study was to identify the features of reactivity of the EEG mu rhythm within an individually determined frequency range in preschoolers with ASD in situations requiring instrumental, emotional and altruistic helping behavior (HB). The study involved children 4–7 years old with ASD (n = 26) and their normally developing peers without the condition (n = 37). Although in most cases, HB was more pronounced in the group of normally developing children, the differences between the groups are significant only for altruistic HP (p < 0.01), and for the situation requiring complex altruistic and emotional HP it approaches significance (p = 0.09). Evaluation of the mu rhythm reactivity indices showed that the tasks invoking complex altruistic and emotional HB bring this indicator down significantly in children with ASD compared to the group of normally developing participants, as shown by the central leads of the left and right hemispheres and the parietal lead of the right hemisphere (C3: p = 0.02 ; C4: p = 0.03; P4: p = 0.03). It is assumed that the detected features stem from the impaired functioning of the MNS and the downstream regulation to the MNS from prefrontal cortex and other areas of the neocortex. The data obtained can be used in development of EEG biofeedback training protocols for children with ASD.
Metastatic Lung Adenocarcinoma to the Oral Cavity
Authors: Mohd Najib Mohd Naqiuddin , Abu Bakar Muhammad Nasri , Hashim Hasme Zam , Mohamad Irfan
Published: April 2023

Primary oral neoplasms are relatively common. They tend to have positive neck adenopathy at presentation. Metastatic deposits are rare, and mainly reported to the soft tissue of the oral cavity and to the jawbones. The possible primaries include gastrointestinal and genitourinary tracts. We report a case of an oral cavity mass with initial complaint of toothache and neck swelling with multiple neck nodes. Biopsies taken from the left retromolar trigone and supraclavicular lymph node revealed poorly differentiated metastatic adenocarcinoma. Computed tomography scan suggested primary lung cancer. Early detection of lung cancer should be the clinician’s concern. The presence of an oral mass already indicates a late stage of lung cancer with poor prognosis.
Osgood-Schlatter Disease in Adult: Would Early Diagnosis and Treatment Improve the Prognosis?
Authors: Sahar Nurul Hidayatullaila , Ramli Anis Safura , Badlishah-Sham Siti Fatimah , Mohd Miswan Mohd Fairudz
Published: April 2023

Osgood-Schlatter Disease (OSD) is a juvenile osteochondritis of tibial tuberosity affecting athletic adolescents. However, the classical feature of persistent para-patellar pain is uncommon in skeletally mature adults. This case presents a 23-year-old gentleman with an 8- year history of bilateral anterior knee pain and swelling. The symptoms began after a sports injury which occurred when he was 15. The diagnosis of OSD was missed at this point as the presentation and radiological features mimic cracked fracture of the tibial tuberosity. Subsequently, he did not obtain medical care which resulted in worsening knee pain and swelling. Recent X-ray showed fragmented apophysis in both knees, supporting the diagnosis of bilateral OSD. Further evaluation suggests that he probably developed OSD long before he presented with the sport injury. This case highlights the importance of early diagnosis and management of OSD in childhood to improve the prognosis and reduce the risk of complications in adulthood.
Antimalarial Activity of Ethanol Extract of Sampare Leaves (Glochidion sp var. Biak) Against Plasmodium falciparum In Vitro
Authors: Umar Khairuddin Zainuddin , P.Utami Yuri , A.Y. Ardi Muhammad
Published: April 2023

Malaria is one of the health problems in the world and in Indonesia. This disease is caused by theprotozoan parasite, the genus Plasmodium. Plasmodium falciparum is the most important parasiticdisease with high morbidity and mortality in the world and tropical countries such as Indonesia inparticular. This study aims to determine the activity of sampare leaf extract in inhibiting the growth ofthe FCR-3 strain of the P. falciparum parasite which causes malaria. Sampare leaves were extracted bymaceration method using 70% ethanol. Extract the results extraction were tested against P. falciparumby in vitro method. 32,67% Yield extract resulted from the extraction process. Phytochemical screeningshows the presence of alkaloid compounds, flavonoids, quinones, saponins, and tannins. The ethanolextract of sampare leaves had IC50 antimalarial activity of 0,125 μg/mL and was categorized very well.Keywords: Antimalarial, Glochidion sp var. Biak, IC50, Plasmodium falciparum.
Analysis of Waste Minimization in Production Time to Increase Production Effectiveness
Authors: Ismail Nalia El-Huda , Sutomo Andri Nugraha Nugraha , Muchtaridi Muchtaridi
Published: April 2023

Lean manufacturing has been widely applied in the industry as an effort to utilize resources efficientlyand systematically. The purpose of this study is to analyze waste time activities and to proposedminimize the time so it will increase the effectiveness of production sucralfate suspension at PT. X.The concept used in this research is lean manufacturing with a value stream mapping (VSM) approach.This method will make it easier to identify waste time activities through current state mapping, todetermine improvement points and to propose improvements by describing the value stream mapping.The research was carried out by calculating and mapping each step of the production of sucralfatesuspension. The total production time needed for the production of one batch of sucralfate suspensionis 5 hours 16 minutes with a value added activity time about 96%, and a necessary non value addedactivity time about 4%. The proposed improvement to minimize waste time is by carrying outproductions activities in parallel. Based on the proposed improvement, the total production time ofsucralfate syrup that can be reduced is 31 minutes.Keywords: Waste Time, Value Stream Mapping.
Phenolics and Flavonoids Content of Wijaya Kusuma Leaves Fractions using Micro-plate Based Assay
Authors: Hikmawanti Ni Putu Ermi , Yumita Agustin , Rafiq Muhammad , Lusiana Lusiana
Published: April 2023

Epiphyllum oxypetalum (DC.) or Wijaya Kusuma (Cactaceae) is an ornamental plant which is knownto contain polyphenol compounds. The purpose to determine the levels of total phenolic and flavonoidcompounds in the fractions of Wijaya Kusuma leaves using microplate-based assay. Each sample wasdetermined phenolic content with Folin-ciocalteu reagent and flavonoid content using AlCl3 on themicroplate. Absorption was measured using a microplate reader. Screening of DPPH radical scavengingactivity was identified using the TLC method. The results showed that the extract and fractions ofthe leaves of Wijaya Kusuma contained phenolic and flavonoid compounds. The ether fraction hadthe highest phenolic content (35,912±0,54776 mgGAE/g) and flavonoids (0,773±0,008 mgQE/g)compared to other fractions (ether>water>ethyl acetate fraction). There is one yellow spot with an Rfvalue of 0,85 in the ether fraction which is thought to be a compound capable of scavenging the DPPHradicals. The ether fraction of Wijaya Kusuma leaves has potential as a source of polyphenols withantioxidant activity. However, further research is needed to evaluate the antioxidant capacity in theether fraction of Wijaya Kusuma leaves.Keywords: Antioxidant, Epiphyllum oxypetalum (DC.) Haw, Flavonoids, Fraction, High-throughputMicroplate Assay, Phenolics.