bluuebunny/crossref_metadata_2025 huggingface dataset:
A Linguistically Motivated Model for Speed and Pausing in Animations of American Sign Language
Authors: Huenerfauth Matt
Published: June 2009

Many deaf adults in the United States have difficulty reading written English text; computer animations of American Sign Language (ASL) can improve these individuals’ access to information, communication, and services. Planning and scripting the movements of a virtual character’s arms and body to perform a grammatically correct and understandable ASL sentence is a difficult task, and the timing subtleties of the animation can be particularly challenging. After examining the psycholinguistics literature on the speed and timing of ASL, we have designed software to calculate realistic timing of the movements in ASL animations. We have built algorithms to calculate the time-duration of signs and the location/length of pauses during an ASL animation. To determine whether our software can improve the quality of ASL animations, we conducted a study in which native ASL signers evaluated the ASL animations processed by our algorithms. We have found that: (1) adding linguistically motivated pauses and variations in sign-durations improved signers’ performance on a comprehension task and (2) these animations were rated as more understandable by ASL signers.
Exploring Visual and Motor Accessibility in Navigating a Virtual World
Authors: Trewin Shari , Laff Mark , Hanson Vicki , Cavender Anna
Published: June 2009

For many millions of users, 3D virtual worlds provide an engaging, immersive experience heightened by a synergistic combination of visual realism with dynamic control of the user’s movement within the virtual world. For individuals with visual or dexterity impairments, however, one or both of those synergistic elements are impacted, reducing the usability and therefore the utility of the 3D virtual world. This article considers what features are necessary to make virtual worlds usable by such individuals. Empirical work has been based on a multiplayer 3D virtual world game called PowerUp, to which we have built in an extensive set of accessibility features. These features include in-world navigation and orientation tools, font customization, self-voicing text-to-speech output, key remapping options, and keyboard-only and mouse-only navigation. Through empirical work with legally blind teenagers and adults with cerebral palsy, these features have been refined and validated. Whereas accessibility support for users with visual impairment often revolves around keyboard navigation, these studies emphasized the need to support visual aspects of pointing device actions too. Other notable findings include use of speech to supplement sound effects for novice users, and, for those with cerebral palsy, a general preference to use a pointing device to look around the world, rather than keys or on-screen buttons. The PowerUp accessibility features provide a core level of accessibility for the user groups studied.
Pirates in DARPA cross-hairs
Authors: Zeichick Alan
Published: June 2009

How to navigate the virtual seas lurking with real pirates.
The unbook
Authors: Greiner Lynn
Published: June 2009

Books and paper have begun to part company, as we learn to love E Ink.
Is Google too big to fail?
Authors: Treese Win
Published: June 2009

Dependence on Google services motivates our common interest in seeing the company survive and thrive.
A digital trail is forever
Authors: Weiss Aaron
Published: June 2009

The data trail we generate through our everyday activity can be reassembled into a detailed account of our past, present, and possibly even future.
GABA’s Control of Stem and Cancer Cell Proliferation in Adult Neural and Peripheral Niches
Authors: Young Stephanie Z. , Bordey Angélique
Published: June 2009

Aside from traditional neurotransmission and regulation of secretion, γ-amino butyric acid (GABA) through GABAAreceptors negatively regulates proliferation of pluripotent and neural stem cells in embryonic and adult tissue. There has also been evidence that GABAergic signaling and its control over proliferation is not only limited to the nervous system, but is widespread through peripheral organs containing adult stem cells. GABA has emerged as a tumor signaling molecule in the periphery that controls the proliferation of tumor cells and perhaps tumor stem cells. Here, we will discuss GABA’s presence as a near-universal signal that may be altered in tumor cells resulting in modified mitotic activity.
CNS Regulation of Glucose Homeostasis
Authors: Lam Carol K. L. , Chari Madhu , Lam Tony K. T.
Published: June 2009

The past decade has hosted a remarkable surge in research dedicated to the central control of homeostatic mechanisms. Evidence indicates that the brain, in particular the hypothalamus, directly senses hormones and nutrients to initiate behavioral and metabolic responses to control energy and nutrient homeostasis. Diabetes is chiefly characterized by hyperglycemia due to impaired glucose homeostatic regulation, and a primary therapeutic goal is to lower plasma glucose levels. As such, in this review, we highlight the role of the hypothalamus in the regulation of glucose homeostasis in particular and discuss the cellular and molecular mechanisms by which this neural pathway is orchestrated.
Unexpected Roles of the Na-K-ATPase and Other Ion Transporters in Cell Junctions and Tubulogenesis
Authors: Krupinski Thomas , Beitel Greg J.
Published: June 2009

Recent work shows that transport-independent as well as transport-dependent functions of ion transporters, and in particular the Na-K-ATPase, are required for formation and maintenance of several intercellular junctions. Furthermore, these junctional and other nonjunctional functions of ion transporters contribute to development of epithelial tubes. Here, we consider what has been learned about the roles of ion pumps in formation of junctions and epithelial tubes in mammals, zebrafish, Drosophila, and C. elegans. We propose that asymmetric association of the Na-K-ATPase with cell junctions early in metazoan evolution enabled vectorial transcellular ion transport and control of intraorganismal environment. Ion transport-independent functions of the Na-K-ATPase arose as junctional complexes evolved.
Preeclampsia: The Role of Angiogenic Factors in Its Pathogenesis
Authors: Wang Alice , Rana Sarosh , Karumanchi S. Ananth
Published: June 2009

Preeclampsia, a systemic syndrome of pregnancy clinically characterized by new onset of proteinuria and hypertension, is associated with significant morbidity and mortality to both mothers and fetuses. The pathogenesis of preeclampsia has been enigmatic; this review will focus on understanding the origins of this disorder. Preeclampsia originates in the placenta, starting with inadequate cytotrophoblast invasion and ending with widespread maternal endothelial dysfunction. Production of placental anti-angiogenic factors, specifically soluble fms-related tyrosine kinase 1 and soluble endoglin, have been shown to be upregulated in preeclampsia. These placental anti-angiogenic factors are released into the maternal circulation; their actions disrupt the maternal endothelium and result in hypertension, proteinuria, and the other systemic manifestations of preeclampsia. The molecular basis for placental dysregulation of these pathogenic factors remains unknown, remains unknown. Hypoxia is likely an important regulator. Other factors such as alterations in the renin-angiotensin-aldosterone axis, immune maladaption, excessive shedding of trophoblast debris, oxidative stress, and genetic factors likely contribute to the pathogenesis of the abnormal placentation. As of 2009, the only successful treatment for preeclampsia is delivery. No definitive preventive strategies have been identified. However, several of the recent observations related to phenotypic causality provide stimuli for the development of novel therapies.
Distinct and novel SLC26A4/Pendrin mutations in Chinese and U.S. patients with nonsyndromic hearing loss
Authors: Dai Pu , Stewart Andrew K. , Chebib Fouad , Hsu Ann , Rozenfeld Julia , Huang Deliang , Kang Dongyang , Lip Va , Fang Hong , Shao Hong , Liu Xin , Yu Fei , Yuan Huijun , Kenna Margaret , Miller David T. , Shen Yiping , Yang Weiyan , Zelikovic Israel , Platt Orah S. , Han Dongyi , Alper Seth L. , Wu Bai-Lin
Published: June 2009

Mutations of the human SLC26A4/PDS gene constitute the most common cause of syndromic and nonsyndromic hearing loss. Definition of the SLC26A4 mutation spectrum among different populations with sensorineural hearing loss is important for development of optimal genetic screening services for congenital hearing impairment. We screened for SLC26A4 mutations among Chinese and U.S. subjects with hearing loss, using denaturing HPLC (DHPLC) and direct DNA sequencing. Fifty-two of 55 Chinese subjects with deafness accompanied by enlargement of the vestibular aqueduct (EVA) exhibited at least one mutant SLC26A4 allele, whereas SLC26A4 mutations were found in only 2 of 116 deaf Chinese patients without EVA. The spectrum of SLC26A4 mutations differed among Chinese and U.S. subjects and included 10 previously unreported SLC26A4 variants: 4 in the Chinese population (p.E303Q, p.X329, p.X467, p.X573) and 6 in the U.S. population (p.V250A, p.D266N, p.F354S, p.D697A, p.K715N, p.E737D). Among the seven novel in-frame missense mutations, five encoded SLC26A4 proteins with substantially reduced Cl−/anion exchange activity as expressed and measured in Xenopus oocytes, but four of these were sufficiently active to allow study of anion selectivity. The only mutant polypeptide exhibiting complete loss of anion exchange function, p.E303Q, was expressed at or near the oocyte surface at near-wild-type levels. Two variants, p.F354S and p.E737D, displayed selective reduction in relative rate of Cl−/HCO3− exchange compared with similarly measured rates of Cl−/Cl− and Cl−/I− exchange. Our data show that mutation analysis of the SLC26A4 gene is of high diagnostic yield among subjects with deafness and bilateral EVA in both China and the U.S. However, the pathogenicity of monoallelic SLC26A4 gene variants in patients with hearing loss remains unclear in many instances.
Long-Term Mortality of Patients Undergoing Cardiac Catheterization for ST-Elevation and Non-ST-Elevation Myocardial Infarction
Authors: Chan Mark Y. , Sun Jie L. , Newby L. Kristin , Shaw Linda K. , Lin Min , Peterson Eric D. , Califf Robert M. , Kong David F. , Roe Matthew T.
Published: June 2009

Background—

There are limited contemporary data comparing long-term outcomes after cardiac catheterization for ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI).

Methods and Results—

We studied patients undergoing cardiac catheterization for STEMI (n=2413) and NSTEMI (n=1974) between 1999 and 2005 with at least 1 significant coronary lesion ≥75%. We compared adjusted mortality rates over restricted time intervals and the differential impact of early revascularization on mortality stratified by ST-elevation status. Between 1999 and 2007, 1274 patients died, with a median follow-up of 4 years. A piece-wise analysis showed a higher adjusted mortality risk for STEMI during the first 2 months (adjusted hazard ratio, 1.85; 95% confidence interval, 1.45 to 2.38) and a lower adjusted mortality risk for STEMI after 2 months (adjusted hazard ratio, 0.68; 95% confidence interval, 0.59 to 0.83). Compared with late or no revascularization, early revascularization was associated with a lower adjusted risk of mortality for both STEMI (adjusted hazard ratio, 0.73; 95% confidence interval, 0.58 to 0.90) and NSTEMI (adjusted hazard ratio, 0.76; 95% confidence interval, 0.65 to 0.89) (
P
for interaction=0.22).

Conclusions—

Among a contemporary cohort of acute MI patients with significant coronary disease during cardiac catheterization, STEMI was associated with a higher risk of short-term mortality, but NSTEMI was associated with a higher risk of long-term mortality. Early revascularization was associated with a similar improvement in long-term outcomes for both STEMI and NSTEMI. These data suggest that in clinical investigations of early revascularization among patients with NSTEMI, extended follow-up may be necessary to demonstrate treatment benefit.
Living Near Major Traffic Roads and Risk of Deep Vein Thrombosis
Authors: Baccarelli Andrea , Martinelli Ida , Pegoraro Valeria , Melly Steven , Grillo Paolo , Zanobetti Antonella , Hou Lifang , Bertazzi Pier Alberto , Mannucci Pier Mannuccio , Schwartz Joel
Published: June 2009

Background—

Particulate air pollution has been consistently linked to increased risk of arterial cardiovascular disease. Few data on air pollution exposure and risk of venous thrombosis are available. We investigated whether living near major traffic roads increases the risk of deep vein thrombosis (DVT), using distance from roads as a proxy for traffic exposure.

Methods and Results—

From 1995 through 2005, we examined 663 patients with DVT of the lower limbs and 859 age-matched controls from cities with population >15 000 inhabitants in Lombardia Region, Italy. We assessed distance from residential addresses to the nearest major traffic road using geographic information system methodology. The risk of DVT was estimated from logistic regression models adjusting for multiple clinical and environmental covariates. The risk of DVT was increased (odds ratio=1.33; 95% confidence interval, 1.03 to 1.71;
P
=0.03 in age-adjusted models; odds ratio=1.47; 95% confidence interval, 1.10 to 1.96;
P
=0.008 in models adjusted for multiple covariates) for subjects living near a major traffic road (index distance of 3 meters, 10th centile of the distance distribution) compared with those living farther away (reference distance of 245 meters, 90th centile). The increase in DVT risk was approximately linear over the observed distance range (from 718 to 0 meters) and was not modified after adjusting for background levels of particulate matter (odds ratio=1.47; 95% confidence interval, 1.11 to 1.96;
P
=0.008 for 10th versus 90th distance centile in models adjusting for area levels of particulate matter <10 μm in aerodynamic diameter in the year before diagnosis).

Conclusions—

Living near major traffic roads is associated with increased risk of DVT.
Dominant-Negative
ALK2
Allele Associates With Congenital Heart Defects
Authors: Smith Kelly A. , Joziasse Irene C. , Chocron Sonja , van Dinther Maarten , Guryev Victor , Verhoeven Manon C. , Rehmann Holger , van der Smagt Jasper J. , Doevendans Pieter A. , Cuppen Edwin , Mulder Barbara J. , ten Dijke Peter , Bakkers Jeroen
Published: June 2009

Background—

Serious congenital heart defects occur as a result of improper atrioventricular septum (AVS) development during embryogenesis. Despite extensive knowledge of the genetic control of AVS development, few genetic lesions have been identified that are responsible for AVS-associated congenital heart defects.

Methods and Results—

We sequenced 32 genes known to be important in AVS development in patients with AVS defects and identified 11 novel coding single-nucleotide polymorphisms that are predicted to impair protein function. We focused on variants identified in the bone morphogenetic protein receptor,
ALK2
, and subjected 2 identified variants to functional analysis. The coding single-nucleotide polymorphisms R307L and L343P are heterozygous missense substitutions and were each identified in single individuals. The L343P allele had impaired functional activity as measured by in vitro kinase and bone morphogenetic protein-specific transcriptional response assays and dominant-interfering activity in vivo. In vivo analysis of zebrafish embryos injected with ALK2 L343P RNA revealed improper atrioventricular canal formation.

Conclusion—

These data identify the dominant-negative allele ALK2 L343P in a patient with AVS defects.
Blood Pressure–Independent Reduction in Proteinuria and Arterial Stiffness After Acute Endothelin-A Receptor Antagonism in Chronic Kidney Disease
Authors: Dhaun Neeraj , MacIntyre Iain M. , Melville Vanessa , Lilitkarntakul Pajaree , Johnston Neil R. , Goddard Jane , Webb David J.
Published: June 2009

Endothelin 1 is implicated in the development and progression of chronic kidney disease and associated cardiovascular disease. We, therefore, studied the effects of selective endothelin-A receptor antagonism with BQ-123 on key independent surrogate markers of cardiovascular risk (blood pressure, proteinuria and renal hemodynamics, arterial stiffness, and endothelial function) in patients with nondiabetic chronic kidney disease. In a double-blind, randomized crossover study, 22 subjects with proteinuric chronic kidney disease received, on 2 separate occasions, placebo or BQ-123. Ten of these subjects also received nifedipine (10 mg) as an active control for the antihypertensive effect of BQ-123. Blood pressure, pulse wave velocity, flow-mediated dilation, renal blood flow, and glomerular filtration rate were monitored after drug dosing. BQ-123 reduced blood pressure (mean arterial pressure: −7±1%;
P
<0.001 versus placebo) and increased renal blood flow (17±4%;
P
<0.01 versus placebo). Glomerular filtration rate remained unchanged. Proteinuria (−26±4%;
P
<0.01 versus placebo) and pulse wave velocity (−5±1%;
P
<0.001 versus placebo) fell after BQ-123, but flow-mediated dilation did not change. Nifedipine matched the blood pressure and renal blood flow changes seen with BQ-123. Nevertheless, BQ-123 reduced proteinuria (−38±3% versus 26±11%;
P
<0.001) and pulse wave velocity (−9±1% versus −3±1%;
P
<0.001) to a greater extent than nifedipine. Selective endothelin-A receptor antagonism reduced blood pressure, proteinuria, and arterial stiffness on top of standard treatment in renal patients. Furthermore, these studies suggest that the reduction in proteinuria and arterial stiffness is partly independent of blood pressure. If maintained longer term, selective endothelin-A receptor antagonism may confer cardiovascular and renal benefits in patients with chronic kidney disease.
Observational Study of Wind Channeling within the St. Lawrence River Valley
Authors: Carrera Marco L. , Gyakum John R. , Lin Charles A.
Published: June 2009

The presence of orography can lead to thermally and dynamically induced mesoscale wind fields. The phenomenon of channeling refers to the tendency for the winds within a valley to blow more or less parallel to the valley axis for a variety of wind directions above ridge height. Channeling of surface winds has been observed in several regions of the world, including the upper Rhine Valley of Germany, the mountainous terrain near Basel, Switzerland, and the Tennessee and Hudson River Valleys in the United States. The St. Lawrence River valley (SLRV) is a primary topographic feature of eastern Canada, extending in a southwest–northeast direction from Lake Ontario, past Montreal (YUL) and Quebec City (YQB), and terminating in the Gulf of St. Lawrence. In this study the authors examine the long-term surface wind climatology of the SLRV and Lake Champlain Valley (LCV) as represented by hourly surface winds at Montreal, Quebec City, and Burlington, Vermont (BTV). Surface wind channeling is found to be prominent at all three locations with strong bidirectionalities that vary seasonally. To assess the importance of the various channeling mechanisms the authors compared the joint frequency distributions of surface wind directions versus 925-hPa geostrophic wind directions with those obtained from conceptual models. At YUL, downward momentum transport is important for geostrophic wind directions ranging from 240° to 340°. Pressure-driven channeling is the dominant mechanism producing northeasterly surface winds at YUL. These northeasterlies are most prominent in the winter, spring, and autumn seasons. At YQB, pressure-driven channeling is the dominant physical mechanism producing channeling of surface winds throughout all seasons. Of particular importance, both YUL and YQB exhibit countercurrents whereby the velocity component of the wind within the valley is opposite to the component above the valley. Forced channeling was found to be prominent at BTV, with evidence of diurnal thermal forcing during the summer season. Reasons for the predominance of pressure-driven channeling at YUL and YQB and forced channeling at BTV are discussed.
Spectral Retrieval of Latent Heating Profiles from TRMM PR Data. Part IV: Comparisons of Lookup Tables from Two- and Three-Dimensional Cloud-Resolving Model Simulations
Authors: Shige Shoichi , Takayabu Yukari N. , Kida Satoshi , Tao Wei-Kuo , Zeng Xiping , Yokoyama Chie , L’Ecuyer Tristan
Published: June 2009

The spectral latent heating (SLH) algorithm was developed to estimate latent heating profiles for the Tropical Rainfall Measuring Mission Precipitation Radar (TRMM PR). The method uses TRMM PR information (precipitation-top height, precipitation rates at the surface and melting level, and rain type) to select heating profiles from lookup tables (LUTs). LUTs for the three rain types—convective, shallow stratiform, and anvil rain (deep stratiform with a melting level)—were derived from numerical simulations of tropical cloud systems from the Tropical Ocean and Global Atmosphere Coupled Ocean–Atmosphere Response Experiment (TOGA COARE) using a cloud-resolving model (CRM).

The two-dimensional (2D) CRM was used in previous studies. The availability of exponentially increasing computer capabilities has resulted in three-dimensional (3D) CRM simulations for multiday periods becoming increasingly prevalent. In this study, LUTs from the 2D and 3D simulations are compared. Using the LUTs from 3D simulations results in less agreement between the SLH-retrieved heating and sounding-based heating for the South China Sea Monsoon Experiment (SCSMEX). The level of SLH-estimated maximum heating is lower than that of the sounding-derived maximum heating. This is explained by the fact that using the 3D LUTs results in stronger convective heating and weaker stratiform heating above the melting level than is the case if using the 2D LUTs. More condensate is generated in and carried from the convective region in the 3D model than in the 2D model, and less condensate is produced by the stratiform region’s own upward motion.
Influence of Daily Rainfall Characteristics on Regional Summertime Precipitation over the Southwestern United States
Authors: Anderson Bruce T. , Wang Jingyun , Gopal Suchi , Salvucci Guido
Published: June 2009

The regional variability in the summertime precipitation over the southwestern United States is studied using stochastic chain-dependent models generated from 70 yr of station-based daily precipitation observations. To begin, the spatiotemporal structure of the summertime seasonal mean precipitation over the southwestern United States is analyzed using two independent spatial cluster techniques. Four optimal clusters are identified, and their structures are robust across the techniques used. Next, regional chain-dependent models—comprising a previously dependent occurrence chain, an empirical rainfall coverage distribution, and an empirical rainfall amount distribution—are constructed over each subregime and are integrated to simulate the regional daily precipitation evolution across the summer season. Results indicate that generally less than 50% of the observed interannual variance of seasonal precipitation in a given region lies outside the regional chain-dependent models’ stochastic envelope of variability; this observed variance, which is not captured by the stochastic model, is sometimes referred to as the “potentially predictable” variance. In addition, only a small fraction of observed years (between 10% and 20% over a given subregime) contain seasonal mean precipitation anomalies that contribute to this potentially predictable variance. Further results indicate that year-to-year variations in daily rainfall coverage are the largest contributors to potentially predictable seasonal mean rainfall anomalies in most regions, whereas variations in daily rainfall frequency contribute the least. A brief analysis for one region highlights how the identification of years with potentially predictable precipitation characteristics can be used to better understand large-scale circulation patterns that modulate the underlying daily rainfall processes responsible for year-to-year variations in regional rainfall.
Effects of Climate Variability on Water Storage in the Colorado River Basin
Authors: Hurkmans Ruud , Troch Peter A. , Uijlenhoet Remko , Torfs Paul , Durcik Matej
Published: June 2009

Understanding the long-term (interannual–decadal) variability of water availability in river basins is paramount for water resources management. Here, the authors analyze time series of simulated terrestrial water storage components, observed precipitation, and discharge spanning 74 yr in the Colorado River basin and relate them to climate indices that describe variability of sea surface temperature and sea level pressure in the tropical and extratropical Pacific. El Niño–Southern Oscillation (ENSO) indices in winter [January–March (JFM)] are related to winter precipitation as well as to soil moisture and discharge in the lower Colorado River basin. The low-frequency mode of the Pacific decadal oscillation (PDO) appears to be strongly correlated with deep soil moisture. During the negative PDO phase, saturated storage anomalies tend to be negative and the “amplitudes” (mean absolute anomalies) of shallow soil moisture, snow, and discharge are slightly lower compared to periods of positive PDO phases. Predicting interannual variability, therefore, strongly depends on the capability of predicting PDO regime shifts. If indeed a shift to a cool PDO phase occurred in the mid-1990s, as data suggest, the current dry conditions in the Colorado River basin may persist.
Assessing the Performance of the Dissipation Parameterizations in WAVEWATCH III Using Collocated Altimetry Data
Authors: Kalantzi Georgia D. , Gommenginger Christine , Srokosz Meric
Published: June 2009

Wave-breaking dissipation is one of the least understood processes implemented in contemporary wave models. Significant effort has been put in its parameterization, but it has not proven to be totally satisfactory, either theoretically or practically. In this work, the WAVEWATCH III (version 2.22; Tolman) wave model is used to evaluate the two wind input/dissipation source term packages that it includes: (i) Wave Model (WAM) cycle 3 (WAMDIG) and (ii) Tolman and Chalikov. Global model outputs were obtained under the same wind forcing for the two dissipation formulations and were collocated in space and time in the north Indian Ocean with Ocean Topography Experiment (TOPEX) altimeter data. The performance of the model was assessed by evaluating the statistical behavior of the collocated datasets. The parameters examined were significant wave height, wind speed, wind direction, wave direction, wave height for fully developed seas, and energy loss due to wave breaking. From the results, the behavior of the input/dissipation formulations in specific wind and wave conditions was identified; that is, the results give insight to the way the two source term packages “work” and how they respond to local wind sea or swell. Specifically, both of the packages were unable to perform adequately during a season when the area can be mostly affected by swell. However, the results confirmed that the examination of only integral spectral wave parameters does not give information on the inherent physical characteristics of the formulations. Further study, on the basis of point spectra, is necessary to examine the formulations’ performance across the wave spectrum.
An Examination of WRF 3DVAR Radar Data Assimilation on Its Capability in Retrieving Unobserved Variables and Forecasting Precipitation through Observing System Simulation Experiments
Authors: Sugimoto Soichiro , Crook N. Andrew , Sun Juanzhen , Xiao Qingnong , Barker Dale M.
Published: June 2009

The purpose of this study is to investigate the performance of 3DVAR radar data assimilation in terms of the retrievals of convective fields and their impact on subsequent quantitative precipitation forecasts (QPFs). An assimilation methodology based on the Weather Research and Forecasting (WRF) model three-dimensional variational data assimilation (3DVAR) and a cloud analysis scheme is described. Simulated data from 25 Weather Surveillance Radar-1988 Doppler (WSR-88D) radars are assimilated, and the potential benefits and limitations of the assimilation are quantitatively evaluated through observing system simulation experiments of a dryline that occurred over the southern Great Plains. Results indicate that the 3DVAR system is able to analyze certain mesoscale and convective-scale features through the incorporation of radar observations. The assimilation of all possible data (radial velocity and reflectivity factor data) results in the best performance on short-range precipitation forecasting. The wind retrieval by assimilating radial velocities is of primary importance in the 3DVAR framework and the storm case applied, and the use of multiple-Doppler observations improves the retrieval of the tangential wind component. The reflectivity factor assimilation is also beneficial especially for strong precipitation. It is demonstrated that the improved initial conditions through the 3DVAR analysis lead to improved skills on QPF.
Coronary Artery Bypass Grafting With Y-Saphenous Vein Grafts
Authors: Hulusi Melih , Basaran Murat , Ugurlucan Murat , Kocailik Ali , Basaran Eylul Kafali
Published: June 2009

Introduction: The saphenous vein is one of the indispensible grafts for coronary revascularization despite the advantages of arterial grafts over veins. It can be used in different configurations with different anastomosis (eg, sequential, composite, or Y-graft) techniques. Our aim was to investigate early and midterm results of Y-type anastomosis of saphenous vein grafts for complete coronary revascularization. Material and methods: Coronary artery bypass grafting (CABG) with Y-graft technique was performed in 512 patients between February 1998 and June 2007. In total, 608 saphenous Y coronary anastomoses were performed. These anastomoses were on first and second obtuse marginal arteries (n: 323), first diagonal and first obtuse marginal arteries (n: 187), posterolateral and posterior descending artery (n: 79), and right coronary artery and posterior descending artery (n: 19). Endareterectomy was performed in 28 patients with severely calcified coronary arteries. Patients were evaluated for early and late survival, newly developing cardiac events, recurring angina, and reinterventions. Results: In the early postoperative period, new myocardial infarction (MI) occurred in 27 (5.2%) patients and mortality in 13 (2.5%). Follow-up included the results of 487 (98%) patients. Mean follow-up duration was 56 ± 24 months. Late mortality occurred in 36 (7.3%) patients, and in 13 (2.6%) patients new MI developed in the remote follow-up. Overall survival including all deaths at 3, 5, and 7 years was 94 ± 0.6%, 86 ± 1.3%, and 83 ± 2.1%, respectively, and actuarial freedom from angina recurrence at 3, 5, and 7 years was 95.2 ± 2.5%, 86.4 ± 3%, and 84.7 ± 4.6%, respectively. Among long-term survivors, 116 patients (25.7%), 49 being symptomatic, with 123 saphenous Y-type anastomoses having undergone angiography studies. Saphenous vein Y grafts were completely patent in 94 anastomoses (76.4%). Conclusions: Saphenous vein Y-type anastomosis technique can safely be used in patients with multivessel coronary artery disease (CAD) with successful long-term outcomes. As with sequential anastomosis, the safety of the technique may be attributed to the distribution of inflow from aorta into multiple vessels.
Doing Business in a Transitional Society
Authors: Luo Yadong , Zhao Hongxin
Published: June 2009

This article addresses how foreign subsidiaries formulate their relational political strategy by responding to the unique parameters of the economic and institutional environment in an emerging market in an attempt to improve their performance. To this end, the authors have developed a model that assesses economic environment antecedents characterizing an emerging market (regulatory distance, industry accessibility, environmental uncertainty, and economic development) as well as the performance consequence of the subsidiaries’ relational political strategy. A possible moderating effect of the firm’s reputation in the host country and length of operations on the relationship between political strategy and local performance is also examined in the model. Our analysis of primary and secondary data concerning 358 foreign-invested enterprises in China generally supports this model.
Poverty and Civil War Events
Authors: Hegre Håvard , Østby Gudrun , Raleigh Clionadh
Published: June 2009

This article examines the link between subnational poverty and the location of civil war events. Drawing on the ACLED dataset, which breaks internal conflicts down to individual events at the local level, we take a disaggregated approach to the study of conflict. Local-level socioeconomic data are taken from the Liberian Demographic and Health Survey. With geographical cells of approximately 76 km 2 as units of analysis, we test how absolute and relative welfare affect the presence and number of conflict events during the 1989-2002 Liberian civil war. We control for neighboring conflict events, distance to Monrovia and national borders, population density, diamond deposits, and ethnic affiliations. War events were more frequent in the richer locations. This may provide better support for “opportunity” explanations than for “relative deprivation” theories of conflict, but we argue that the relative weakness of the Liberian government makes it difficult to distinguish between the two.
“You Will Be Like God”: Fascination of Force and Social Conformism in Two War Episodes
Authors: Monti Martino Rossi
Published: June 2009

Recalling some historical episodes and philosophical reflections, this essay attempts to show how and why ordinary human beings turn into murderers. As proved by several psychological experiments, almost everyone, if put in a certain situation, can be easily convinced to act cruelly toward other people. This happens because everyone is somehow subject to conformism and to the fascination of power and force.
Are Client—Counselor Ethnic/Racial Matches Associated With Successful Rehabilitation Outcomes?
Authors: Whitfield Harold Wayne , Venable Riley , Broussard Shanna
Published: June 2009

The purpose of this study was to determine if client—counselor ethnic/racial matches were associated with successful vocational rehabilitation (VR) outcomes. There was no significant difference in acceptance rates for VR services. Client— counselor ethnic/racial matches had a significantly higher rehabilitation rate than client—counselor mismatches. Reasons for closure were examined with logistic regression analysis. “Achieved an employment outcome,” “individual in institution,” and closure for “all other reasons” were significantly associated with client—counselor matches. This study also examined the amount of time counselors took to determine eligibility, the amount of funds counselors expended on services, the amount of time applicants were in the VR program, and the weekly wages of applicants at case closure while controlling for disability and education at application. A multivariate analysis of variance revealed no significant differences. Implications of these findings are discussed.
Whose Time Is It?
Authors: Gager Constance T. , Sanchez Laura A. , Demaris Alfred
Published: June 2009

Children’s time use—and specifically the time they spend on household chores—is an important arena for understanding social change. However, few studies accurately depict the multiple factors influencing children’s household labor, including parent’s and children’s available time and parent’s levels of work/family stress. We address these gaps by exploring how parents’ and children’s time use and perceived stress constrains time for housework. We employ data on 3,560 households from a national survey of children’s time use. We find several factors elevate children’s housework hours, including parents’ work/family stress, fathers’ work hours, having more siblings, being female, and being an older child. Contrary to the time availability principle, children’s curricular and extracurricular activities and hours spent in paid labor are associated with more housework. A follow-up analysis suggests that this is not accounted for by an unmeasured family attribute promoting children’s achievement across multiple spheres of activity.
Evaluating Monitoring Systems in the European Social Fund Context
Authors: Iannacci Federico , Cornford Tony , Cordella Antonio , Grillo Francesco
Published: June 2009

In contrast to the prevailing image of monitoring systems as technical systems, it is proposed that they should rather be conceived of as social endeavors at exchanging information. Drawing on the monitoring and evaluation framework of Cornford, Doukidis, and Forster, the concept of information agreement is suggested as a way of assessing the quality of monitoring systems in context. Preliminary implications are discussed with regard to the quality of information, the information agreement being conceptualized as a tacit, and/or explicit agreement between and among participating government partners about the quality of information.
An exploratory study of physical activity and perceived barriers to exercise in ambulant people with neuromuscular disease compared with unaffected controls
Authors: Phillips Margaret , Flemming Nicola , Tsintzas Kostas
Published: June 2009

Objective: To determine activity patterns and perceived barriers to exercise in ambulant people with neuromuscular disease compared with ambulatory controls.

Design: Prospective controlled parallel group design.

Setting: Outpatient clinic and community.

Subjects: Thirteen ambulatory people with neuromuscular disease and 18 ambulatory controls.

Main measures: Heart rates were recorded during sedentary activity and treadmill walking at various speeds to indicate activity threshold (flex heart rate), followed by ambulatory heart rate monitoring over two weekdays and one weekend day. The EPIC-Norfolk Physical Activity Questionnaire-2 and Barriers to Physical Activity and Disability Survey were completed.

Results: Participants with neuromuscular disease were less active than controls as estimated by both the EPIC-Norfolk Physical Activity Questionnaire-2, P<0.004, and the flex heart rate method, P<0.05. The number of perceived barriers was greater in the neuromuscular group, a mean of 7 (SD 4.2) barriers, compared with mean 3 (SD 2.1) barriers for controls, P<0.05. Specific barriers differed, with the barriers of `pain', `lack of energy' and `exercise is too difficult' showing the greatest discrepancy and being higher in the neuromuscular disease group.

Conclusion: Physical activity, as determined by two different methods, was less and barriers to exercise greater in people with neuromuscular disease compared with healthy controls. Specific barriers were different in the two groups. This information could assist in the design of achievable and effective exercise programmes for people with neuromuscular disease.
The effects of a `home-based' task-oriented exercise programme on motor and balance performance in children with spastic cerebral palsy and severe traumatic brain injury
Authors: Katz-Leurer Michal , Rotem Hemda , Keren Ofer , Meyer Shirley
Published: June 2009

Objectives: To evaluate the feasibility and the ability to recruit and retain children with severe traumatic brain injury or cerebral palsy, and their families, to a simple home-based exercise programme and to assess the immediate and short-term effects of such intervention on reducing impairment and improving function.

Study design: Randomized clinical trial.

Participants: Twenty children aged 7—13 years, with traumatic brain injury (N = 10) or cerebral palsy (N = 10) who were independent ambulators. Five children from each group were randomly assigned to a control group — regular daily activities, or to an experimental group — regular daily activities plus a home-based task-oriented exercise programme of sit-to-stand and step-up exercise, for six weeks.

Outcome measures: Feasibility: The number of participants who completed the programme protocol. Efficacy: Timed Up and Go Test and Functional Reach Test were used as functional balance tests. Maximal isometric strength was assessed by using a hand-held dynamometer; walking performance was assessed by the 10 m walk test, 2-minute walk test and Energy Expenditure Index.

Results: Nine children completed all parts of the training programme. At the end of the intervention period an increase of 3—4 cm in the mean Functional Reach Test and a reduction of 1.6 ± 2.1 seconds in the Timed Up and Go Test were noted (P<0.01) in the experimental group while no changes were noted in the control group. In all other outcomes assessed no significant differences were noted between groups. The positive change in balance performance in the experimental group was maintained during a six-week follow-up period.

Conclusions: A home-based task-oriented exercise programme can improve balance performance in children with spastic cerebral palsy or severe traumatic brain injury.
Foetal response to maternal coffee intake: role of habitual versus non-habitual caffeine consumption
Authors: Mulder EJH , Tegaldo L , Bruschettini P , Visser GHA
Published: June 2009

Little is known about the effect on the human foetus of long-term and acute exposure to caffeine. We studied the organisation of foetal sleep-wake states in 13 healthy near-term foetuses over a wide range of maternal plasma caffeine concentrations (0—13 μg/mL) reflecting normal lifestyle conditions (day 0) and again following intake of two cups of regular coffee (~300 mg of caffeine) intermitted by 50 h of abstinence (day 2; acute effects). On either day, 2 h simultaneous recordings were made of foetal heart rate, general-, eye-, and breathing-movements. The recordings were analysed for the presence of each of four foetal behavioural states: quiet- and active-sleep, quiet- and active-wakefulness. There was a linear relationship between maternal caffeine content and the incidence of foetal general movements during active sleep on day 0 (R = 0.74; P < 0.02). After coffee loading on day 2, foetuses of non- or low-caffeine consumers showed increases in active wakefulness (P < 0.001), general movements (P < 0.05) and heart rate variation (P < 0.01) but lower basal heart rate (P < 0.01) compared with their day 0 values. The changes in foetal heart rate (variation) and behaviour occurred between 90 and 180 min post-consumption. In contrast, foetuses of habitual caffeine consumers remained unaffected suggestive of foetal tolerance to caffeine. The results indicate differential performance between foetuses regularly exposed to caffeine and those caffeine-naive, both under normal maternal lifestyle conditions and in response to maternal coffee ingestion.
Siblings of Infants and Toddlers With Disabilities in Early Intervention
Authors: Kresak Karen , Gallagher Peggy , Rhodes Cheryl
Published: June 2009

The current study investigated the perceptions of families regarding the inclusion of siblings of children with disabilities by early intervention providers. Eighty-seven respondents who had a child enrolled in one state’s Part C early intervention program completed the survey. Both quantitative and qualitative data were collected and analyzed. Results indicated a significant correlation (a) between having goals for siblings on the Individualized Family Service Plan and parents’ report of whether siblings were included by the service provider in sessions, (b) between wanting goals and the respondent’s relationship to the child, and (c) between having goals and county of residence. Qualitative results verified how siblings were included in early intervention routines by early intervention providers, that goals related to siblings were not often included in the Individualized Family Service Plan, and that parents reported that siblings wanted more information about the child’s disability. In addition, families viewed explaining the disability to siblings as a critical component for helping siblings understand the child with disabilities.
A Fair Test of the Fair Innings?
Authors: Oliver Adam
Published: June 2009

Priority setting in health care under conventional rules of health economic evaluation is based upon the ethos of attempting to maximize post-treatment health gain given available health care resources. In his later years, Alan Williams advocated the ``fair innings argument,'' which balances differences in whole lifetime experiences of health with differences in post-treatment outcomes when prioritizing people for health care. This article reports a study that presented respondents with a number of abstract health care decision contexts in an attempt to test the extent to which post-treatment health maximization, the fair innings argument, or, indeed other ``decision rules,'' are evident in the respondents' answers. The results indicate that the most commonly observed decision rule differs substantially across health care contexts, and therefore imply that rather than pursue an overarching decision rule, it may be more appropriate to vary the rule according to the particular health care decision context under consideration.
Effects of International Trade and Economic Development on Quality of Life
Authors: Mullen Michael R. , Doney Patricia M. , Ben Mrad Selima , Ye Sheng Shirley
Published: June 2009

The authors integrate theories from macromarketing, economics, and sociology to develop a conceptual model assessing the effects of international trade and economic development on physical quality of life (PQOL), individual freedom, and the environment (carbon dioxide [CO2] emissions and environmental performance). The study introduces new measures of individual freedom and environmental performance to the macromarketing literature. Research hypotheses are tested on time-lagged data from 104 countries using structural equation modeling. Results suggest that international trade is associated with economic growth that enhances the well-being of people and their ‘‘visible’’ natural environment but with a deleterious impact on global warming through increased CO2 emissions. Increases in PQOL and individual freedom are associated with lower CO2 emissions and improved environmental performance. These findings have important implications for public policy makers, marketing academics, and practitioners.
A Robotic Neural Interface for Autonomous Positioning of Extracellular Recording Electrodes
Authors: Wolf Michael T. , Cham Jorge G. , Branchaud Edward A. , Mulliken Grant H. , Burdick Joel W. , Andersen Richard A.
Published: June 2009

In this paper we describe a set of algorithms and a novel miniature device that together can autonomously position electrodes in neural tissue to obtain high-quality extracellular recordings. This robotic system moves each electrode to detect the signals of individual neurons, optimize the signal quality of a target neuron, and then maintain this signal over time. Such neuronal signals provide the key inputs for emerging neuroprosthetic medical devices and serve as the foundation of basic neuroscientific and medical research. Experimental results from extensive use of the robotic electrodes in macaque parietal cortex are presented to validate the method and to quantify its effectiveness.