bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of H2O and OH Masers in the Region Formation of a Young High Mass Stellar Object (S255 NIRS 3)
Authors: Ashimbaeva N. T. , Lekht E. E. , Krasnov V. V. , Shutenkov V. R.
Published: December 2024

The results of a study of a star formation region are presented. S255 IR, where a young high-mass star is forming (20M•). Observations in H2O were carried out on RT-22 in Pushchino, and in the OH lines at the Large Radio Telescope in Nance (France). Data observations in the H2O line at 1.35 cm were used for the period 2017–2023. Our observations in H2O showed the existence strong flares, especially in 2023. Drift was also observed emission by radial velocity for most spectral details and predominantly in the direction of decreasing radial velocity.
In OH lines 18 cm in 2008 no emission was detected. We observed OH emission in the main lines 1665 and 1667 MHz in 2015, 2023 and 2024. Structures of spectra, degrees of circular and linear polarizations varied greatly during these epoch. However, at the same time the longitudinal magnetic field vectors had predominantly two directions: relative to the vertical, i. e. almost perpendicular to the jet or along it. Zeeman splitting was detected only in the 1667 MHz line for one pair of features: 2.26 and 2.37 km/s. The amount of splitting 0.11 km/s corresponds to a longitudinal magnetic field value of 0.31 mGs; the field is directed towards the observer.
It is assumed that the appearance of OH maser emission in 2015 associated with an accretion flares. Significant structure changes OH spectra, their degrees of polarization and very strong flares H2O maser in 2023 may be associated with a new possibility accretion flares in S255 IR.
Components of Evoked Potentials in Frontal Cortex Areas Associated with Image Classification and Independent of Physical Characteristics of Stimuli
Authors: Moiseenko G. А. , Koskin S. А. , Pronin S. V. , Chikhman V. N. , Vershinina Е. А. , Zhukova О. V.
Published: December 2024

Currently, there is a problem of increasing the objectivity of electrophysiological methods for assessment of visual acuity. The purpose of this work: to study the characteristics of cognitive evoked potentials associated with events in the frontal areas of the brain in the tasks of images classification of objects by semantic features. We used visual stimuli, divided into the following classes: by semantic features – into living and nonliving objects, and by spatial frequency ranges – into broadband contour images (white on a black background) and narrowband, in which the low-frequency or high-frequency ranges were isolated by digital filtration. The prepared images were presented to the subjects on the display. In each series of studies, the subjects were instructed to classify the images by the features of “living/nonliving” object, regardless of the physical characteristics of the stimuli. It was shown that the P200 component of evoked potentials in the ventrolateral areas of the frontal cortex depends on the semantic properties of the stimuli – images of animate and inanimate objects and does not depend on such physical characteristics as the presence/absence of high-frequency or low-frequency filtering. In this paper, as a result of the analysis of individual data in two series of studies, the results of measurements of the amplitudes and latent periods for the P200 component of evoked potentials for different (by semantics) classes of contour images with high-frequency and low-frequency filtering at selected several individual spatial frequencies and contour unfiltered images with different instructions to the subjects are presented. The obtained results may be used in the development of a new additional method for assessing visual acuity using visual evoked potentials.
Evil has many names: davol, natemago, dajeskraja (on the issue of macedonian demononyms)
Authors: Verizhnikova Elena V. , Chivarzina Alexandra I.
Published: December 2024

According to the Christian and folk religious beliefs, the devil is the embodiment of evil and the cause of misery in the world, and therefore his name is subject to taboo. The material from Macedonian fairy tales, folk narratives and Christian legends testifies to the numerous euphemisms that are used in this meaning. In addition to proper names and borrowed nominations (vrag, bes; sotona, đavol etc.), as well as figurative folk attributes (rogatiot, kuciot, ednonogiot, nečestiviot, crveniot etc.), among the nomination models there are also examples of word fusion that go back to the formulas of curse and verbal amulet (natemago, daeskrajata). This article conciders the designations of devil in the Macedonian language, the stages of the origin of demononyms, the transformation of their meanings and functioning in contemporary Macedonian usage.
Evaluación de indicadores de sostenibilidad del suelo y de salud del cultivo en sistemas convencionales y orgánicos de yuca
Authors:   Universidad de Córdoba, De-La-Ossa-Puello Luis Felipe , Barrera-Violeth José Luis ,   Universidad de Córdoba, Combatt-Caballero Enrique Miguel ,   Universidad de Córdoba
Published: December 2024

El cultivo de yuca (Manihot esculenta Crantz) en Colombia, se realiza empleado sistemas de siembra, como el monocultivo, con prácticas que vulneran la sostenibilidad del agroecosistema, por degradación de los suelos, erosión y extracción de nutrientes y, entre éstas, el uso de maquinarias y la aplicación de fertilizantes inorgánicos. Debido a esta situación, se ha generado un interés por el implemento de técnicas de manejo orgánico, enfoque que ha demostrado producir beneficios al sistema suelo-planta. En esta investigación se evaluaron los niveles de sostenibilidad en sistemas de cultivo de yuca, del municipio de Ciénaga de Oro-Córdoba, Colombia. Para ello fueron definidos tres sistemas de cultivo de manejo orgánico y tres con sistemas convencionales. Cada 30 días, durante periodo de 18 meses, se analizaron 10 indicadores de calidad de suelos y 10 de salud de cultivos, con base en la metodología de diagnóstico rápido de la sostenibilidad de los cultivos. Los sistemas orgánicos obtuvieron mejores resultados para las variables de calidad de suelo, con promedios que oscilaron entre 7,00 y 9,00; igualmente, para salud de cultivo, con promedios entre 5,00 y 10,00 y respecto a los sistemas convencionales, con valores entre 2,00 y 8,00, en proporción para los indicadores de calidad de suelo y salud de cultivo. La implementación de prácticas agrícolas con manejo orgánico se convierte en una alternativa importante para mejorar la productividad en los sistemas agronómicos de la región.
Pre-campaign discourse in the Romanian presidential election of 2024: An analysis of characterisations
Authors: Botas Adina
Published: December 2024

This paper analyses presidential election pre-campaign communication highlighting the main themes in the descriptions made by candidates about themselves and their opponents, via online news media. The discourse selected for analysis was collected between August and October 2024. The dataset is composed of extracts from public statements and interviews of top candidates focused on image crafting, i.e. self- and other-characterisation, examined through a 3D lens: componential analysis of speech acts, lexical semantics and Critical Discourse Analysis CDA – agency and representation (van Leeuwen 2008). Starting from a landmark profile of the ‘desirable candidate’, the study outlines the subjective representations of what the candidates consider important themes of self-definition in the preparatory phase of the pre-campaign, in an aim to highlight a general image of ‘the public from the mind of the candidate’.
The Impact of Stress During Adolescence and the Prevalence of Pediatric Obesity
Authors: Olakunri Olatunbosun , Venkataraman Venkat
Published: December 2024

Obesity is a chronic condition that can be attributed to myriad factors including socioeconomic status, biological risk factors, and various environmental factors. These factors can be considered stress factors, and exposure to various levels of stress can impact the development of stress within the pediatric patients. The purpose of this study is to assess the association between the environmental, mental, social, physical, and psychological stress adolescents are exposed to and how they contribute to the prevalence of pediatric obesity throughout the United States. Understanding these risk factors can help us as a community and most importantly as clinicians develop better insight to our patients as a whole and therefore be able to provide better, well rounded care.
The Role of Med13 in Proteaphagy
Authors: Sauer John , Friedson Brittany , Cooper Katrina
Published: December 2024

Regulation of proteasomes is important for adaptation to cellular stress. Previous studies have shown that following starvation stress, proteasomes are targeted for destruction by autophagy. However, how cells control proteasomes in response to nitrogen starvation remains unclear. This study delves into the intricate interplay between Med13, proteaphagy, and stress response regulation, aiming to elucidate their roles in cellular survival mechanisms. It focused on the highly conserved Cdk8 kinase module (CKM) of the Mediator complex a that plays a pivotal involvement in cellular signaling and gene regulation under stress conditions. During the investigation, we asked if the degradation of specific proteasome subunits was dependent upon Med13, a member of the CKM. The results suggest a novel role of Med13 in the degradation of the Rpn8 proteasome subunit, shedding light on its specific impact on proteasome dynamics during stress. Moving forward, the research endeavors to validate and refine these initial findings through further experimentation and analysis. Replication of experiments and additional time courses, particularly focusing on the Rpn11 subunit, are planned to bolster the observed effects of Med13 on specific proteasome subunits. Furthermore, the exploration of Med13's involvement in proteaphagy under different stress conditions, such as carbon starvation, promises to broaden our understanding of stress-induced cellular responses. In conclusion, this research underscores the critical role of Med13 in cellular survival mechanisms during nitrogen starvation and its potential implication in proteasome degradation. These findings contribute significantly to the comprehension of stress response regulation and hold promise for future investigations into proteaphagy and related cellular processes.
The Effects of Sleep Quality, Covariates and a Possible Intervention
Authors: Reddy Pranav S. , Tarditi Mia , Gupta Adarsh , Jermyn Richard , Venkataraman Venkat
Published: December 2024

Sleep is an essential biological process needed to maintain adequate physiologic function. Research has provided growing evidence that chronic failure to get enough sleep is associated with increased risk for obesity, depression, diabetes, hypertension, stroke, cardiovascular disease, and mortality. Sleep deprivation is threatening the health of up to 45% of the world's population. Furthermore, sleep disorders were found to be associated with significantly higher rates of health care utilization and cost, accounting for $94.9 billion in costs each year in the United States. Earlier data from this project demonstrated a correlation between sleep quality and pain. METHODS: Patients were recruited from Family Medicine and NMI. For a pilot study on intervention, student volunteers were recruited. Data was collected and statistical analyses were carried out with IBM SPSS v29.0 and Prism 12.0. RESULTS: Several covariates exhibited correlations with sleep quality. The sleep quality was surprisingly poor even in patients seen for well visits or annual examinations. It was also poor in student volunteers. CONCLUSIONS: The analyses revealed correlations between covariates (that are associated with the Body Mass Index (BMI), education levels) and sleep and circadian rhythms. Preliminary findings suggest a very short intervention was useful for students.
Penerapan Lima Pilar STBM Terhadap Kejadian Stunting
Authors: B Muslimin , Ruqaiyah Ruqaiyah , Imran Ali , Suhartini Suhartini
Published: December 2024

Kasus stunting di Kabupaten Maros mengalami penurunan dari tahun 2020 sebanyak 3812 kasus atau 13,04 % menjadi 2892 kasus atau 9,47 %, namun pada tahun 2022 terjadi sebaliknya yaitu peningkatan yang signifikan dalam jumlah kasus maupun prevalensinya kasusnya meningkat menjadi 3750 kasus atau menjadi 12,82 %. Di Kecamatan Tompobulu kasus stunting telah mengalami penurunan dari Tahun 2020 sebesar 12,69% turun menjadi 12,11% pada tahun 2021. Dan pada Tahun 2022 turun menjadi 9,69%. Oleh karena itu dalam penelitian ini akan kami analisa tentang hubungan lima pilar STBM terhadap kasus stunting di Kecamatan Tompobulu Kabupaten Maros. Jenis penelitian dalam penelitian ini yaitu penelitian dengan menggunakan Survey dengan pendekatan Cross Sectional Study. Populasi dalam penelitian ini seluruh balita stunting yang dilakukan pemeriksaan dengan jumlah 146 balita. Sampel dalam penelitian ini yaitu seluruh populasi. Hasil penelitian menunjukkan adanya hubungan antara CTPS (0,005), Pengelolaan air minum dan makanan (0,005), pengamanan sampah RT (0,000), dan pengamanan limbah cair (0,000) dengan kejadian stunting. Sedangkan stop BABS tidak memiliki hubungan dengan kejadian stunting (0,911). Kesimpulan pada penelitian ini yaitu 4 variable dalam penelitian memiliki hubungan dengan terjadinya stunting. Disarankan agar masyarakat setempat untuk meningkatkan kesadaran akan pentingnya sanitasi yang ada diwilayahnya agar dapat menekan tingginya angka stunting.
Kata Kunci: 5 Pilar, Sanitasi Total Berbasis Masyarakat (STBM), Stunting
Inisiasi Menyusui Dini (IMD) dan Lingkar Lengan Atas (LILA) Ibu Hamil dengan Kejadian Stunting di Kabupaten Takalar
Authors: Sukmawati Sukmawati , Yusnita Yusnita , Zakaria Zakaria , Chaerunnimah Chaerunnimah
Published: December 2024

Survei Status Gizi Indonesia (SSGI) tahun 2022 menunjukkan prevalensi stunting di Indonesia mencapai 21,6%, Sulawesi Selatan 27,4% dan Kabupaten Takalar 31,3% masih diatas cut off WHO yaitu 20%. Standar emas pemberian makanan bayi dan anak yakni melakukan Inisiasi Menyusui Dini (IMD), memberikan ASI eksklusif, memberikan Makanan Pendamping Air Susu Ibu (MP-ASI) dan meneruskan pemberian ASI sampai dengan dua tahun. Tujuan penelitian untuk mengetahui hubungan Inisiasi Menyusui Dini (IMD) dan lingkar lengan atas  (LILA) ibu hamil dengan kejadian stunting. Penelitian ini merupakan penelitian observasional yang bersifat analitik dengan pendekatan case control secara retrospektif. Penelitian dilaksanakan di Kelurahan Bontokadatto Kabupaten Takalar pada Juli 2023 sampai Maret 2024. Sampel adalah seluruh balita yang mengalami stunting sebanyak 20 orang sebagai kasus, kontrol adalah balita tidak stunting sebanyak 20 orang. Uji statistik yang digunakan adalah uji chi square. Hasil penelitian menunjukkan tidak terdapat hubungan yang signifikan antara Inisiasi Menyusui Dini (IMD) dengan kejadian stunting pada anak balita dengan p-value 0,27 (p-value > 0,05). Tidak terdapat hubungan yang signifikan antara lingkar lengan atas ibu hamil dengan kejadian stunting pada anak balita dengan p-value 0,72 (p-value > 0,05) di Kabupaten Takalar. Inisiasi Menyusui Dini (IMD) merupakan faktor risiko kejadian stunting pada balita dengan nilai OR 3,05 (OR > 1) dan lingkar lengan atas ibu saat hamil menjadi faktor protektif kejadian stunting dengan nilai OR 0,58 (OR < 1). Kepada ibu dan petugas kesehatan untuk melakukan pemberian inisiasi menyusui dini pada bayi baru lahir.
Habitat Categorization and Vegetation Mapping of Kumana National Park, Sri Lanka
Authors:   Department of Zoology, Faculty of Applied Sciences, University of Sri Jayewardenepura, Sri Lanka, Rodrigo Pasindu , Gunathilaka Charani ,   Department of Zoology, Faculty of Applied Sciences, University of Sri Jayewardenepura, Sri Lanka, Jayasekara Dulan ,   Department of Zoology, Faculty of Applied Sciences, University of Sri Jayewardenepura, Sri Lanka, Mahaulpatha Dharshani ,   Department of Zoology, Faculty of Applied Sciences, University of Sri Jayewardenepura, Sri Lanka
Published: December 2024

Remote sensing constitutes a broad and influential discipline that has assumed a significant role in vegetation mapping on a global scale in recent years. The availability of an accurate vegetation map assists future ecological studies and the management of protected areas. This study was conducted to identify and map the available habitats in Kumana National Park (KNP), Sri Lanka. We utilized multiple environmental covariates obtained via field surveys and remote sensing techniques for the initial categorization of habitats based on principal component analysis. Vegetation maps for KNP were generated by applying multiple classification algorithms to Sentinel 2 multispectral satellite imagery. The maximum likelihood classification (MLC) model generated the most accurate and detailed vegetation map for KNP, which was verified with ground truth data (overall accuracy of 93%; Kappa, 87%). The study’s findings furnish precise insights into the vegetation cover of KNP, thereby augmenting knowledge on the spatial distribution of habitats to support the future work of researchers and park managers. This map offers significantly improved resolution and spatial detail compared to previous maps. It also increased the number of identified habitat types from four to six. These findings can be used to identify critical areas for both terrestrial and aquatic fauna within KNP and support habitat conservation and management strategies in the park.
Inovasi Pengembangan Karakter Islami dalam Konteks Global: Pendekatan Pragmatis untuk Tantangan Modern
Authors: Anas Amin Alamsyah
Published: December 2024

Studi ini membahas bagaimana inovasi dalam pengembangan karakter islami berperan penting dalam menghadapi tantangan modern, seperti globalisasi, perkembangan teknologi, dan perubahan sosial-budaya. Di tengah meningkatnya sekularisasi dan pengaruh budaya asing, menjaga nilai-nilai islami, khususnya dalam dunia pendidikan, menjadi semakin mendesak. Studi ini berupaya mengidentifikasi berbagai inovasi yang sudah diterapkan di negara-negara muslim serta mengeksplorasi pendekatan pragmatis yang mampu mempertahankan nilai-nilai islami di era modern. Dengan menggunakan pendekatan kepustakaan berbasis digital, pendekatan kualitatif dan dan pendekatan deskriptif, studi ini menganalisis berbagai literatur dari artikel jurnal, buku elektronik, dan laporan kebijakan pendidikan. Hasilnya menunjukkan bahwa teknologi digital, seperti aplikasi mobile dan platform e-learning, semakin digunakan untuk mempermudah penyampaian nilai-nilai islami secara interaktif kepada generasi muda muslim. Selain itu, pendekatan pembelajaran berbasis proyek dan kontekstual juga terbukti efektif dalam menghubungkan nilai-nilai islami dengan situasi kehidupan sehari-hari, membuat pendidikan karakter islami lebih relevan dan mudah diaplikasikan. Kolaborasi internasional antara lembaga pendidikan Islam di berbagai negara juga menjadi kunci dalam memperkuat kurikulum dan metode pengajaran yang sesuai dengan tuntutan globalisasi. Studi ini juga menemukan bahwa pendekatan pragmatis, seperti penyesuaian terhadap modernitas dan pengembangan keterampilan interpersonal yang berlandaskan nilai-nilai islami, sangat penting untuk membantu generasi muda muslim mempersiapkan diri dalam menghadapi dunia profesional tanpa kehilangan identitas keislaman mereka. Secara keseluruhan, inovasi dan pendekatan pragmatis yang diuraikan dalam studi ini memberikan solusi yang relevan dan aplikatif untuk menjaga serta mengembangkan karakter islami di tengah tantangan modern global.
АДАПТИВНІ СТРАТЕГІЇ МАРКЕТИНГУ ТЕРИТОРІЙ: ЗАЛУЧЕННЯ ІНВЕСТИЦІЙ І ТУРИСТИЧНИХ ПОТОКІВ
Authors: Кришан Олексій , Яременко Володимир , Чалапко Лідія
Published: December 2024

У статті розглядаються адаптивні стратегії маркетингу територій як важливий інструмент для сталого економічного розвитку регіонів в умовах глобалізації та конкуренції. Метою дослідження є створення комплексної моделі, яка враховує соціально-економічні, культурні та екологічні аспекти для залучення інвестицій і туристичних потоків. Аналіз показує, що соціально-економічні фактори, культурна спадщина та екологічні ініціативи є критично важливими для успіху маркетингових стратегій. Дослідження міжнародного досвіду і крос-культурний аналіз дозволяють виявити ефективні практики. Результати вказують на необхідність залучення місцевих громад у процес прийняття рішень для формування адаптивних стратегій. Стаття містить рекомендації щодо практичної імплементації стратегій, спрямованих на покращення регіонального розвитку
УПРАВЛІННЯ КОНФЛІКТАМИ ЯК СКЛАДОВА ЕФЕКТИВНОГО МЕНЕДЖМЕНТУ
Authors: Чернікова Наталія , Бутенко Віктор , Ісаєнко Юлія
Published: December 2024

У статті розглянуто теоретичні та практичні аспекти управління конфліктними ситуаціями у сучасних організаціях. Доведено важливість ідентифікації причин виникнення конфліктів та їхньої своєчасної діагностики для мінімізації негативних наслідків. Зазначено, що ефективне управління конфліктами передбачає використання таких стратегій, як співпраця, компроміс, медіація та переговори, що сприяють зміцненню довіри в колективі, покращенню комунікації та досягненню загальних цілей. Встановлено роль емоційного інтелекту та комунікаційних навичок менеджера, як ключових чинників, для запобігання ескалації конфліктів. Також у статті представлено сучасні методи управління конфліктами, зокрема застосування цифрових інструментів для моніторингу та аналізу ситуацій у колективі. Зроблено висновок, що ефективне управління конфліктами є важливим чинником успішного менеджменту, оскільки забезпечує стабільність організації, підвищує продуктивність праці та сприяє створенню позитивного корпоративного клімату.
Greenspaces reduce the heat-related mortality: A systematic review and meta-analysis
Authors: Patwary Muhammad Mainuddin , Sakib Imran Chowdhury , Badhon Md Ismay Azam , Bardhan Mondira , Sakhvidi Mohammad Javad Zare , Sikder Dana , Dadvand Payam , Bell Michelle L. , Browning Matthew , Astell-Burt Thomas , Kabir Md Pervez , James Peter
Published: December 2024

Greenspace has been increasingly recognized for its role in mitigating heat-related mortality in the context of climate change. This systematic review and meta-analysis synthesized evidence from 43 studies covering over 160 million deaths. Using a random-effects meta-analysis, we found that high-greenness areas were associated with a lower risk of all-cause mortality during heat (≥90th percentile), with a pooled relative risk (RR) of 1.07 (95%CI: 1.00–1.15, n=11), compared to low greenness areas (pooled RR: 1.22, 95%CI: 1.09–1.36, n=11) with substantial heterogeneity (I²=88%). Sensitivity analyses showed consistent associations between high greenness and reduced mortality risk, though non-significant upon excluding 95th percentile heat-mortality studies. This quantitative evidence suggests that greenspace may play a role in reducing heat-related mortality risk. While the findings indicate the potential for urban greening as a mitigation strategy, the evidence is limited, warranting further investigation in the context of climate change.
ДЕРЖАВНИЙ КОНТРОЛЬ ЗА СУБ’ЄКТАМИ ПІДПРИЄМНИЦЬКОЇ ДІЯЛЬНОСТІ: АДМІНІСТРАТИВНО-ПРАВОВІ ЗАСАДИ ОРГАНІЗАЦІЇ ТА ФУНКЦІОНУВАННЯ
Authors: Бліхар Марія Миронівна
Published: December 2024

Метою статті є дослідження основних аспектів та проблемних питань адміністративно-правового регулювання процесів організації та функціонування державного контролю за суб’єктами підприємницької діяльності. У дослідженні використано загальнонаукові методи аналізу та спеціальні прийоми наукового пізнання, зокрема: системний аналіз, діалектичний аналіз, порівняльно-правовий аналіз, метод узагальнення та систематизації. Результати. Проведені дослідження проблемних питань адміністративно-правового регулювання процесів організації та функціонування державного контролю за суб’єктами підприємницької діяльності дозволили виявити вагомі проблеми забезпечення такого контролю, серед яких є: (1) недостатній рівень законодавчого й нормативно-правового регулювання діяльності інституту державного контролю за суб’єктами підприємницької діяльності; (2) несистематизованість та суперечність норм адміністративно-правового регулювання державного контролю за суб’єктами підприємницької діяльності; (3) недосконалість класифікації видів державного контролю за суб’єктами підприємницької діяльності. Встановлено домінуючу роль чинників війни на процеси організації та функціонування державного контролю за суб’єктами підприємницької діяльності. Висновки. Сучасні виклики і небезпеки глобального та локального характеру спричинюють виникнення проблем адміністративно-правового регулювання процесів організації та функціонування державного контролю за суб’єктами підприємницької діяльності, внаслідок чого існуючі норми чинного законодавства виявляються неефективними, потребують перегляду та удосконалення. Доведено необхідність посилення адміністративно-правового регулювання процесів організації та функціонування державного контролю за суб’єктами підприємницької діяльності, зокрема, на регіональному та місцевому рівні, особливо в тих регіонах, де ведуться активні бойові дії, спричинені збройною військовою агресією російської федерації.
Investigation of heavy metals desorption enhancement procedures in low-permeability contaminated soils
Authors: Bacsó Tamás , Tóth Márton
Published: December 2024

A significant amount of hydrocarbon contaminants (therefore heavy metal components) has remained in the soil due to careless industrial activities. Effective remediation is difficult, especially in low-permeability soils because it is extremely difficult to get desorption. A lot of research has been conducted on extreme soil acidification, batching of oxidants, air-fluid injection and electrokinetic treatment, there were successful but due to the risk from extreme loads, these methods can only be used solely in controlled ex-situ environments. This paper investigates an eco-friendly in situ treatment with carbamide peroxide in low-permeability silty clay. After several repetitions, the result of tests proved Cu component was fully adsorbed on clayey-silt among applied concentration and circumstances which applied, while two other components were partially adsorbed. Moreover, the experiments carried out to enhancement of desorption proved to be successful for Cu, Zn and Mn with carbamide peroxide.
Investigation of groundwater potential utilizing geospatial techniques in Owerri, Nigeria
Authors: Okoli Emeka Austin , Agbasi Okechukwu Ebuka , Akaolisa Casmir Chukwuemeka Zanders , Ikoro Diugo Okereke , Ubechu Bridget Odochi , Ifeanyichukwu Kenechukwu Agbonma , Onyeawuna Uzochi Bright
Published: December 2024

This study used geospatial approaches to examine the potential of groundwater within the study area. Analytic Hierarchy Process (AHP) method was used combining various parameters including Rainfall (39.5%), Geology (23.5%), Slope (12.5%), Drainage Density (8.0%), LULC (6.1%), Lineament Density (5.4%), and Soil Type (5.0%) for an integrated geospatial analysis to assess the potential for groundwater in the study area. Pairwise comparisons were used to assess the relative importance of each parameter. AHP determined these weights after the pairwise matrices were completed. These weights show the relative importance of the themes when assessing the study area's potential for applications such as land-use planning or natural resource management. The AHP technique allows for the systematic evaluation and ranking of alternatives based on a variety of criteria. A groundwater potential index (GPI) map was created by combining all of these thematic maps and classifying the research area into three zones: poor (0.001 %), fair (41.092 %) good (58.686 %), and excellent (0.261 %) groundwater potential areas. The findings showed significant groundwater potential in regions with higher lineament density, low to average slope, and suitable land use and land cover. The weighted overlay strategy was reliable, according to the consistency ratio (CR) analysis of 0.043884. This work shows the importance of an integrated RS and GIS analysis for determining groundwater potential. The results help identify locations with higher groundwater potential and enable sustainable use of groundwater resources.
Edge detection of tomographic images using traditional and deep learning tools
Authors: Dobróka Tünde Edit , Szűcs István , Dobróka Mihály
Published: December 2024

Edge detection is regularly used as a fundamental operation for correctly identifying and measuring some required features. In a grey-level image, an area where the grey-level value moves from a high value to a low value or vice versa is considered an edge. Edges are indicative of a boundary between an object and a background or between two objects. Consequently, edge detection in earth sciences is an important tool for locating geological features and determining their shapes and sizes. Edge detection usually forms a part of the geophysical interpretation or inversion procedure. Seismic tomography is a straightforward field of applying edge detection because the tomogram can be directly considered as an image. In the tomographic reconstruction of seismic travel time data, care must be taken to keep the propagation of data errors to the model space under control. The noise - especially the outliers in the data sets - can cause appreciable distortions in the tomographic imaging. To reduce the noise sensitivity well-developed tomography algorithms can be used. On the other hand, the quality of the tomogram can further be improved by using image processing tools. This is especially important in edge detection, as it is extremely sensitive to noise. In the paper, we present two ways to find robust edge detection. At first, remaining in the framework of traditional image processing a robust Cauchy–Steiner filter is used to improve the quality of edge detection in tomographic images. In the second part of the paper Deep Learning algorithm developed for edge detection is shown and investigating its noise sensitivity the robustness of the method is demonstrated.
Cancer-related thrombosis: impact of biological sex on the risk of rethrombosis and bleeding
Authors: Adrián Silvia García , Pérez Claudia Iglesias , Carmona-Bayonas Alberto , Morán Laura Ortega , Pérez Jaime Rubio , Del Prado Purificación Martínez , De Castro Eva Martínez , Neria Fernando , Pérez Isaura Fernández , De Herreros Marta García , Campos Marta Carmona , Escobar Ignacio García , Balanyà Rut Porta , González David Marrupe , Fonseca Paula Jiménez , García María Esperanza Guirao , Cánovas Manuel Sánchez , Langa José Muñoz , Segura Pedro Pérez , Vidal Ma José Méndez , Martín Andrés J. Muñoz , Medical Oncology Spanish Society of
Published: December 2024

Patients with cancer present a higher risk of rethrombosis and bleeding secondary to anticoagulant treatment than individuals without cancer. Given the lack of specific clinical trials, the decision regarding the optimal duration of treatment must consider multiple factors, including sex. The current study used data from the international, prospective TESEO Registry that includes consecutive patients diagnosed with cancer-associated thrombosis (CAT). Between July 2018 and December 2022, 2,823 patients were included in the TESEO Registry, 1,351 (48%) of whom were female. The most common venous thromboembolic event (VTE) in both sexes was pulmonary embolism (PE), with an incidence of 58.0% among men and 54.3% in women (p=0.045). After a median follow-up of 6.9 months (IQR, 1.9-14.4), the rethrombosis rate at the end of follow up was 10.0% in males and 15.0% in females (p=0.14). The location of the primary tumor in the gastrointestinal tract was associated with a greater risk of rethrombosis, whereas sex had no significant impact. Men presented twice as many major bleeds. Additional risk factors for major bleeding included situations of risk due to tumor site or thrombocytopenia, as well as the presence of active tumor bleeding at the time of VTE diagnosis. Overall survival was higher among women. Given the higher incidence of major bleeding among men, sex should be deemed a relevant factor when deciding on the duration of anticoagulant treatment in cancer patients.
FVIII peptides presented on HLA-DP and identification of an A3 domain peptide binding with high affinity to the commonly expressed HLA-DP4
Authors: Miranda Mariarosaria , Hansen Bjarke Endel , Wehbi Batoul , Porcheddu Valeria , Van Alphen Floris P.J. , Kaijen Paul , Fijnvandraat Karin , Lacroix-Desmazes Sebastien , Van den Biggelaar Maartje , Maillere Bernard , Voorberg Jan , Consortium EDUC
Published: December 2024

The development of neutralizing antibodies (inhibitors) against coagulation factor VIII (FVIII) poses a major challenge in hemophilia A (HA) treatment. The formation of FVIII inhibitors is a CD4+ T-cell dependent mechanism which includes antigen presenting cells (APCs), B- and T-helper lymphocytes. APCs present FVIII derived peptides on major histocompatibility complex class II (MHC-II) to CD4+ Tcells. We previously established a mass spectrometry based approach to delineate the FVIII repertoire presented on HLA-DR and HLA-DQ. In this study, specific attention was directed towards the identification of FVIII peptides presented on HLA-DP. A data-set of naturally processed FVIII peptides was generated by incubating human FVIII with immature monocytes-derived dendritic cells (moDCs) from HLA-typed healthy donors. Using this method, we identified 176 to 1352 different HLA-DP presented peptides per donor, including 26 different FVIII derived peptides. The most frequently presented peptides derived from the A3, and C2 domains of FVIII. Comparison of the FVIII repertoire presented on HLA-DP with that presented on HLA-DR revealed considerable overlap but also suggested preferential presentation of specific peptides on either HLA-DR or HLA-DP. Fourteen FVIII peptides presented on HLA-DP were synthesized and evaluated for their binding ability to the commonly expressed HLA-DP4 molecule which is highly prevalent in the Caucasian population. Peptide binding studies showed that 7 of 14 peptides competed with a reference peptide to HLADP4. Interestingly, an A3 domain derived peptide bound with high affinity to HLA-DP4 positioning this peptide as a prime candidate for the development of novel peptide-based tolerogenic strategies for FVIII inhibitors.
Characterization of tumor microenvironment and cell interaction patterns in testicular and diffuse large B-cell lymphomas
Authors: Autio Matias , Brück Oscar , Pollari Marjukka , Karjalainen-Lindsberg Marja-Liisa , Beiske Klaus , Jørgensen Judit Mészaros , Holte Harald , Pellinen Teijo , Leivonen Suvi-Katri , Leppä Sirpa
Published: December 2024

The tumor microenvironments (TME) of diffuse large B-cell lymphoma (DLBCL) subgroups have remained poorly characterized. Here, we dissected the composition and spatial organization of the TME in germinal center B-cell (GCB), activated B-cell (ABC), and testicular DLBCLs (T-DLBCL) using gene expression profiling and multiplex immunohistochemistry. We found that high proportions of M2-like tumor-associated macrophages (TAMs) and cytotoxic tumor-infiltrating T cells (TILs) were characteristic of ABC DLBCL TME. Furthermore, high CD8+ TIL content translated to favorable outcomes. In contrast, GCB DLBCL TME was enriched in CD4+ TILs, regulatory TILs, and a higher M1-like/M2-like TAM ratio, and high proportions of TAMs and Granzyme B+ cells associated with worse survival. TILs and TAMs interacted more frequently with M2-like TAMs and cytotoxic TILs in the ABC DLBCLs contrary to GCB subtype, where the interactions were more abundant with other TILs and CD4+ TILs. In T-DLBCL, TME resembled that of ABC DLBCL with a higher proportion of M2-like TAMs and cytotoxic cells, except that checkpoint-positive TILs were less prominent compared to DLBCL NOS. Cytotoxic TILs also interacted more with TILs and TAMs. A high amount of CD163+ TAM interactions with distinct TILs translated to unfavorable survival both in GCB DLBCL and T-DLBCL, whereas a high number of interactions between TILs and TAMs, CD4+ TILs and TAMs, and CD4+ TILs and other TILs associated with favorable outcomes only in T-DLBCL. Together, our data demonstrate biologically and clinically relevant differences in the composition of and cellular interactions in the TME between various DLBCL entities.
Binding of therapeutic Fc-fused factor VIII to the neonatal Fc receptor at neutral pH associates with poor half-life extension
Authors: Reyes-Ruiz Alejandra , Delignat Sandrine , Bhale Aishwarya Sudam , Daventure Victoria , Lacombe Robin V. , Dourthe Leslie , Christophe Olivier , Justesen Sune , Venkataraman Krishnan , Dimitrov Jordan D. , Lacroix-Desmazes Sebastien
Published: December 2024

Fusion of therapeutic proteins to the Fc fragment of human IgG1 promotes their FcRn-mediated recycling and subsequent extension in circulating half-life. However, different Fc-fused proteins, as well as antibodies with different variable domains but identical Fc, may differ in terms of extension in half-life. Here we compared the binding behaviour to FcRn of Fc-fused FVIII, Fc-fused FIX and two human monoclonal HIV-1 broadly-neutralizing IgG1, m66.6 and VRC01 with identical Fc. While all molecules bound FcRn at acidic pH, only rFVIIIFc and m66.6 interacted with FcRn at neutral pH. In silico modelling predicted a role for charged residues in the C1 and C2 domains of FVIII, and in the variable domains of m66.6, in the neutral binding to FcRn. Accordingly, mutations of key positively charged amino-acids in the FVIII C1C2 domains decreased the binding of the protein to FcRn at pH 7.4 in vitro and increased the half-life of rFVIIIFc in VWFKO mice. Our findings suggest that the removal of positively charged patches on Fc-fused proteins to ameliorate FcRn recycling without affecting therapeutic efficacy, may improve their pharmacokinetic properties.
A Comparative Study of Response and Toxicity between Weekly Cisplatin plus Radiotherapy Versus Weekly Carboplatin plus Radiotherapy in Locally Advanced Squamous Cell Carcinoma of Head-Neck
Authors: Ahmed Riad Mahfujul
Published: December 2024

Background: Head and neck cancers are the common cancers in developing countries. Concurrent chemoradiotherapy is the treatment of choice for locally advanced stage III to IVB squamous cell carcinoma of head and neck. Carboplatin possesses comparable treatment response and better tolerability than cisplatin. Objectives: The study has been conducted to elucidate the comparable efficacy and favorable toxicity profile of carboplatin instead of cisplatin. Materials and Methods: This study was conducted at National Institute of Cancer Research and Hospital, Dhaka from March 2018 to March 2019 over 60 patients divided into 2 groups. Group A patients received cisplatin 40 mg/ m2 and group B patients received carboplatin AUC 2 along with 66 Gy in 33 fractions of radiation. Treatment response and toxicities was evaluated periodically. Results: Total 12 (40%) patients of arm A and 8 (26.7%) patients of arm B had complete response, 10 (33.4%) patients of arm A and 12 (40%) patients of arm B had partial response, 6 (20%) patients of arm A and 3 (10%) patients of arm B had stable disease and 2 (6.7%) patients of arm A and 7 (23.3%) patients of arm B developed progressive disease. Cisplatin showed more vomiting (57.6%), nephrotoxicity (55.2%), ototoxicity (33.9%) and neurotoxicity (35.4%). On the other hand, carboplatin showed more myelosuppression (anemia 43.6%, neutropenia 44.5% and thrombocytopenia 64.3%). Conclusion: This study concluded that, both cisplatin and carboplatin have comparable efficacy and carboplatin has favorable safety profile.
J Enam Med Col 2021; 11(3): 173−179
Postoperative Reduction of Opioids Using 0.5% Plain Bupivacaine Through Port Sites at the End of Laparoscopic Cholecystectomy
Authors: Islam Md Ashraful , Khanum Easnem , Rahman Nelufa Tahera , Haque Md Rezaul
Published: December 2024

Background: In present days, laparoscopic cholecystectomy is the gold standard technique for the treatment of gallstone diseases. Effective pain control is an essential component for the patients during postoperative period. Objectives: The aim of this study was to evaluate the effects of port site infiltration of local anesthetics (Inj. 0.5% bupivacaine) in reduction of pain and opioid usages during postoperative period following laparoscopic cholecystectomy. Materials and Methods: A randomized control trial prospective analytical study was conducted in the department of Anesthesiology of Enam Medical College & Hospital in Bangladesh. The patients subjected to laparoscopic cholecystectomy were the study population. Total 60 patients were selected and randomly allocated into two groups as “control group” and “study group”. Study group assigned to receive 0.5% bupivacaine at port sites. The evaluation of postoperative pain was done according to the numeric pain rating scale. Data regarding percentage of analgesic consumed and duration of hospital stay were recorded and analyzed. Results: The mean age of the patients in control group was 44.26±15.56 years and in study group 38.50±12.87 years (p=0.20). Mean weight of the patients was 61.13±8.25 kg in control group and 59.33±8.27 kg in study group (p=0.09). Male female ratio in control group was 11:19 and 8:22 in study group. Mean pain score at 4 hours was significantly lower in the study group compared to control group. Additional analgesics were required 86% in control group and 47% in study group. The mean duration of hospital stay in control group and study group was 2.6 days and 1.6 days respectively. Conclusion: Infiltration of bupivacaine into port sites is simple, inexpensive, and effective technique to reduce postoperative pain and opioid requirements. It can be conventionally practiced for laparoscopic cholecystectomy operation.
J Enam Med Col 2021; 11(3): 180−184
Expression of Estrogen Receptor, Progesterone Receptor and HER-2/Neu among Bangladeshi Women with Invasive Breast Cancer at a Tertiary Care Hospital
Authors: Biswas Md Mamun Ali , Shirin Afroz , Al Monsur Md Sayed , Sikder Abdul Mannan
Published: December 2024

Background: Now-a-days determination of estrogen receptor (ER), progesterone receptor (PR) and HER-2/neu expression pattern by immunohistochemistry in invasive breast cancer have become the standard procedure for breast cancer management. Objective: To see the expression pattern of estrogen receptor, progesterone receptor and HER-2/neu in Bangladeshi women with invasive breast carcinoma. Materials and Methods: This retrospective study was performed in 67 cases of invasive breast cancer. Estrogen receptor (ER), progesterone receptor (PR) and HER-2/ neu expression pattern were assessed by immunohistochemistry using monoclonal antibodies for detecting estrogen and progesterone receptors, and polyclonal antibody for detecting HER-2/neu. Results: All the cases were graded according to Nottingham Modification of Bloom- Richardson system. Of those, Grade I tumours were 14 (20.89%), Grade II tumors were 45 (67.16%) and Grade III tumors were 8 (11.95%). Both ER and PR positive reactivity were the same and it was found 50 (74.63%) and HER-2/neu reactivity patterns were found negative in 45 (67.16%) cases and positive in 22 (32.84%) cases. Conclusion: ER, PR and HER-2/neu expression do not correlate with each other, so it is recommended that each test should be independently determined by immunohistochemistry in all cases of invasive breast cancer. All equivocal cases of HER-2/neu (score 2+) should be analysed by FISH technique to find out the percentage of real score.
J Enam Med Col 2021; 11(3): 185−189
College News Vol. 12(1)
Authors: Cheif Editor in
Published: December 2024

Abstract not available 
J Enam Med Col 2022; 12(1): 59
From the desk of Editor-in-Chief Vol. 12(2)
Authors: Khan Md Aminul Haque
Published: December 2024

Abstract not available
J Enam Med Col 2022; 12(2): I
PENGEMBANGAN MATERI PENCEGAHAN BULLYING UNTUK GURU BK MADRASAH
Authors: Nuryono Wiryo , Mardiani Desika Putri , Minarsih Ni Made Marlin , Istianah Farida , Ningrum Mallevi Agustin , Sania Farah Nikmatus , Siftia Rusydi Wasilatur Rahmah , Ayu Arisona Tria Putri
Published: December 2024

Bullying merupakan permasalahan serius yang sering terjadi di lingkungan sekolah, termasuk di madrasah, yang dapat berpengaruh negatif terhadap kesehatan mental dan perkembangan siswa. Guru Bimbingan dan Konseling (BK) harus memiliki peran dan strategi dalam mencegah dan menangani perilaku bullying di sekolah. Artikel ini membahas tentang pelaksanaan pelatihan pengembangan materi pencegahan bullying yang ditujukan untuk meningkatkan kompetensi guru BK madrasah dalam menciptakan lingkungan belajar yang aman dan kondusif.Pelatihan ini dirancang untuk memberikan pemahaman mendalam tentang pengertian bullying, jenis-jenisnya, dampaknya terhadap siswa, contoh kasus, dan strategi intervensi yang efektif dalam menanggulangi pelaku dan permasalahan bullying. Pendekatan pelatihan meliputi metode partisipatif, seperti pemaparan materi bullying, diskusi dan sharing, serta simulasi kasus bullying yang pernah terjadi di sekolah. Hasil pelatihan menunjukkan bahwa guru BK madrasah mampu merancang materi pencegahan bullying yang lebih sistematis, adaptif, dan sesuai dengan kebutuhan siswa di lingkungan mereka
ANALISIS INDEKS KERENTANAN SEISMIK BERDASARKAN NILAI vs30 PADA ZONA TERDAMPAK GEMPA BUMI (Studi Kasus: Gempa Cianjur 21 November 2022)
Authors: Mutiara Jannah Dea
Published: December 2024

Gempa bumi merupakan salah satu bencana alam yang sering terjadi di Indonesia. Gempa bumi Cianjur 21 November 2022 berdampak pada kerusakan bangunan yang memiliki kesesuaian pola dengan jalur sesar lokal yang baru teridentifikasi. Dampak kerusakan yang terjadi akibat perambatan gelombang seismik dipermukaan dapat dianalisis berdasarkan nilai indeks kerentanan seismik (Kg). Kg dapat diperoleh menggunakan pendekatan empiris dengan parameter utama nilai vs30. Data vs30 pada penelitian ini menggunakan data vs30 yang bersumber dari Atlas vs30 Badan Geologi. Penelitian ini bertujuan untuk mengetahui parameter seismik berupa nilai faktor amplifikasi (A0), frekuensi dominan (f0), dan Kg pada zona kerusakan yang terjadi akibat gempa bumi Cianjur. Hasil penelitian menunjukkan nilai A0 pada Kabupaten Cianjur bervariasi antara 100-750, f0 bervariasi antara 0.8-6.4 Hz, dan Kg bervariasi antara 0.1-22. Pada zona terdampak gempa Cianjur nilai A0 bervariasi antara 0.8-1.8, nilai f0 antara 1.6-3.6 Hz, serta nilai Kg antara 0.1-2. Zona terdampak gempa Cianjur memiliki nilai Kg yang relatif rendah dibandingkan dengan nilai Kg se-Kabupaten Cianjur. Kondisi ini menunjukkan bahwa kawasan dengan nilai Kg yang lebih tinggi dapat berpotensi menyebabkan terjadinya kerusakan yang lebih parah, terutama pada wilayah endapan, alur sungai, dan pesisir di Kabupaten Cianjur.
STABILISASI TANAH EKSPANSIF DI KECAMATAN LUMBIR, KABUPATEN BANYUMAS, JAWA TENGAH
Authors: Budianta Wawan
Published: December 2024

Tanah ekspansif dijumpai di beberapa lokasi di Kecamatan Lumbir, Kabupaten Banyumas, Provinsi Jawa Tengah. Keberadaan tanah ekspansif ini mempunyai implikasi terhadap banyaknya kerusakan jalan di lokasi tersebut yang dikarenakan oleh sifat mudah mengembang yang dimiliki oleh tanah ekspansif. Penelitian ini bertujuan untuk melakukan stabilisasi tanah ekspansif di lokasi penelitian dalam skala laboratorium. Tiga sampel tanah diambil di lokasi penelitian dan dilakukan analisis ukuran butir, kandungan mineralogi dan indeks plastisitas. Percobaan laboratorium penambahan kapur dilakukan pada tiga perlakuan yaitu 2,5%, 5%, dan 7,5%. Hasil analisis distribusi ukuran butir, menunjukkan bahwa persentase ukuran butir lempung yang rendah dan didominasi oleh ukuran butir lanau dan termasuk ke dalam golongan loam dan silt loam serta menunjukkan ketiga sampel memiliki gradasi yang cukup buruk. Hasil plotting nilai batas atterberg pada grafik plastisitas, sampel termasuk ke dalam kelompok CH (lempung plastisitas tinggi) dan CL (lempung plastisitas rendah). Analisis mineralogi menunjukkan bahwa sampel tanah tersusun atas mineral kaolinit dan monmorilonit. Kemudian, percobaan dengan melakukan penambahan kapur pada tanah ekspansif dapat menurunkan nilai indeks plastisitas. Penurunan terbesar terjadi pada sampel dengan penambahan kapur 7,5% yang memiliki nilai penurunan indeks plastisitas sebesar 51,23%.