bluuebunny/crossref_metadata_2025 huggingface dataset:
Approach for Tattoo Detection and Identification Based on YOLOv5 and Similarity Distance
Authors: Pocevičė Gabija , Stefanovič Pavel , Ramanauskaitė Simona , Pavlov Ernest
Published: June 2024

The large number of images in the different areas and the possibilities of technologies lead to various solutions in automatization using image data. In this paper, tattoo detection and identification were analyzed. The combination of YOLOv5 object detection methods and similarity measures was investigated. During the experimental research, various parameters have been investigated to determine the best combination of parameters for tattoo detection. In this case, the influence of data augmentation parameters, the size of the YOLOv5 models (n, s, m, l, x), and the three main hyperparameters of YOLOv5 were analyzed. Also, the efficiency of the most popular similarity distances cosine and Euclidean was analyzed in the tattoo identification process with the purpose of matching the detected tattoo with the person’s tattoo in the database. Experiments have been performed using the deMSI dataset, where images were manually labeled to be suitable for use by the YOLOv5 algorithm. To validate the results obtained, the newly collected tattoo dataset was used. The results have shown that the highest average accuracy of all tattoo detection experiments has been obtained using the YOLOv5l model, where mAP@0.5:0.95 is equal to 0.60, and mAP@0.5 is equal to 0.79. The accuracy for tattoo identification reaches 0.98, and the F-score is up to 0.52 when the highest cosine similarity tattoo is associated. Meanwhile, to ensure that no suspects will be missed, the cosine similarity threshold value of 0.15 should be applied. Then, photos with higher similarity scores should be analyzed only. This would lead to a 1.0 recall and would reduce the manual tattoo comparison by 20%.
Fracture and Deflection of Orthodontic Miniscrews—A Systematic Review
Authors: Stefaniak Katarzyna , Jedliński Maciej , Mazur Marta , Janiszewska-Olszowska Joanna
Published: June 2024

Orthodontic miniscrews (MSs) are used for enhancing orthodontic anchorage either by supporting the teeth of the reactive unit or by obviating the need for the reactive unit altogether. Despite MSs’ popularity, their clinical application is not lacking in complications. The limited space of the insertion site (inter-radicular space), temporary use (limiting osseointegration) and the necessity to minimize the biological cost of insertion (bone incision) required the size of this auxiliary to be reduced, making it susceptible to mechanical failure. This review aimed to investigate factors influencing MS plastic deformation and fracture. The search applied five engines: PubMed, PMC, Web of Science, Scopus, Embase, and Ebsco. Quality assessment was performed according to the QUIN tool. After a thorough search process, 22 articles were included in this review. The most important factor influencing miniscrews’ plastic deformation and fracture was the screw diameter. The MS length and metal alloy did not influence its plastic deformation or fracture. The cylindrical design of the screw is preferable. If the cortical bone thickness in the insertion site exceeds 3 mm, pre-drilling upon insertion is recommended. Orthodontic MSs should not be reused. There is a need for high-quality clinical studies on the subject of MS deformation and fracture. The PROSPERO number is CRD42024509895.
Modified Lip Repositioning Surgery in the Treatment of Gummy Smile
Authors: Arruda Cesar Augusto Signori , Sousa Filipa Passos , Alves Ricardo Castro
Published: June 2024

The smile is a characteristic that expresses emotions and affects interpersonal relationships, significantly impacting self-esteem and influencing personal and professional life. The growing emphasis on aesthetics has made patients increasingly well-informed and demanding regarding available procedures. Excessive gingival display (EGD) can result from various factors, such as altered passive eruption, vertical maxillary excess, and short or hyperactive upper lip, among others. In this case report, where EGD was caused by upper lip hypermobility, the proposed treatment involved the modified lip repositioning surgical technique (MLRS) using sutures in the modified horizontal mattress technique, aiming to limit muscle and tissue movement and to approximate the mucosal edges. The outcome was an improved aesthetic harmony of the smile, with a more suitable position of the upper lip during spontaneous smiling, as observed in a six-month follow-up.
From Waste to Resource: Compositional Analysis of Olive Cake’s Fatty Acids, Nutrients and Antinutrients
Authors: Paié-Ribeiro Jessica , Baptista Filipa , Teixeira José , Guedes Cristina , Gomes Maria José , Teixeira Alfredo , Barros Ana Novo , Pinheiro Victor , Outor-Monteiro Divanildo
Published: June 2024

The olive oil industry, recognised for its beneficial products for health and food culture, generates a significant amount of by-products that, if not appropriately managed, can pose considerable environmental challenges. This study examined six olive cakes (OC) from the Trás-os-Montes and Alto Douro regions, collected on different dates and mills: two obtained by pressing (COC), two by centrifugation (TPOC), including one partially pitted and one dehydrated, and two exhausted (EOC), which were subjected to conventional chemical analyses, namely dry matter (DM), organic matter (OM), crude fat (CF), crude protein (CP), neutral detergent fibre (NDF), acid detergent fibre (ADF), acid detergent lignin (ADL) profiling fatty acid (FA) and phosphorus and phytic acid content. The dehydrated TPOC had only 8% moisture content (due to drying), followed by EOC with 10% and COC (65–79%). The CF content was high in COC 1 (14.5% in DM), residual in EOC (1.5%) and intermediate in TPOC (9–10%). CP ranged from 5.3 to 7.3%. Notably, NDF levels were high (>65% in 5 samples; pitted TPOC 57.4%) and very lignified (ADL > 23%). Different FA profiles were observed: COC had the highest monounsaturated (76.36 g/100 g), while EOC had the highest saturated (16.56 g/100 g) and polyunsaturated (14.14 g/100 g). Phosphorus and phytic acid content (g/100 g) of EOC 2, TPOC pitted, TPOC dehydrated, COC 1 and COC 2 showed similar values to each other (mean of 0.12 ± 0.02 and 0.44 ± 0.0, respectively), with EOC 1 having the lowest levels (0.07 ± 0.01 and 0.26 ± 0.04, respectively). These results highlight the potential of OCs, especially dry TPOC, which offers transport, conservation and utilisation benefits.
AHAC: Advanced Network-Hiding Access Control Framework
Authors: Xu Mudi , Chen Benfeng , Tan Zhizhong , Chen Shan , Wang Lei , Liu Yan , San Tai Io , Fong Sou Wang , Wang Wenyong , Feng Jing
Published: June 2024

In the current context of rapid Internet of Things (IoT) and cloud computing technology development, the Single Packet Authorization (SPA) protocol faces increasing challenges, such as security threats from Distributed Denial of Service (DDoS) attacks. To address these issues, we propose the Advanced Network-Hiding Access Control (AHAC) framework, designed to enhance security by reducing network environment exposure and providing secure access methods. AHAC introduces an independent control surface as the access proxy service and combines it with a noise generation mechanism for encrypted access schemes, replacing the traditional RSA signature method used in SPA protocols. This framework significantly improves system security, reduces computational costs, and enhances key verification efficiency. The AHAC framework addresses several limitations inherent in SPA: users need to know the IP address of resources in advance, exposing the resource address to potential attacks; SPA’s one-way authentication mechanism is insufficient for multi-level authentication in dynamic environments; deploying the knocking module and protected resources on the same host can lead to resource exhaustion and service unavailability under heavy loads; and SPA often uses high-overhead encryption algorithms like RSA2048. To counter these limitations, AHAC separates the Port Knocking module from the access control module, supports mutual authentication, and implements an extensible two-way communication mechanism. It also employs ECC and ECDH algorithms, enhancing security while reducing computational costs. We conducted extensive experiments to validate AHAC’s performance, high availability, extensibility, and compatibility. The experiments compared AHAC with traditional SPA in terms of time cost and performance.
Enhancement of Tricyclazole Analysis Efficiency in Rice Samples Using an Improved QuEChERS and Its Application in Residue: A Study from Unmanned Arial Spraying
Authors: Lee Ye-Jin , Kim So-Hee , Eun Hye-Ran , Kim Su-Min , Jeong Mun-Ju , Baek Jae-Woon , Lee Yoon-Hee , Noh Hyun Ho , Shin Yongho
Published: June 2024

Enhancements to the analytical method for the determination of tricyclazole in rice samples have been applied to monitor residues during unmanned aerial spraying. The acetonitrile extraction technique QuEChERS was improved by the incorporation of ethyl acetate and 0.1% formic acid, which significantly elevated the recovery rates. Furthermore, the purification process was refined by integrating both primary–secondary amine (PSA) and C18 in the dSPE method, achieving a substantial improvement in reducing matrix effects (MEs) and increasing recovery efficiency. The optimized method demonstrated an impressive % ME value at −3.1%, with a limit of quantitation (LOQ) established at 0.01 mg/kg, and recovery rates between 94.7 and 95.6% at 0.01, 0.1, and 2 mg/kg. Using two types of adjuvants (stickers) during multi-copter spraying markedly improved the initial tricyclazole deposition on rice panicles, with residue levels initially increasing from 0.35 mg/kg to between 0.68 and 1.60 mg/kg. Residues in hulled rice at harvest (10 days post-application) remained well below the maximum residue limit (MRL) of 0.7 mg/kg, ranging from 0.02 to 0.11 mg/kg, thus affirming the safety and efficacy of adjuvants in residue management.
A Price-and-Branch Algorithm for Network Slice Optimization in Packet-Switched Xhaul Access Networks
Authors: Klinkowski Mirosław
Published: June 2024

Network slicing is a concept introduced in 5G networks that supports the provisioning of multiple types of mobile services with diversified quality of service (QoS) requirements in a shared network. Network slicing concerns the placement/allocation of radio processing resources and traffic flow transport over the Xhaul transport network—connecting the 5G radio access network (RAN) elements—for multiple services while ensuring the slices’ isolation and fulfilling specific service requirements. This work focuses on modeling and optimizing network slicing in packet-switched Xhaul networks, a cost-effective, flexible, and scalable transport solution in 5G RANs. The considered network scenario assumes two types of network slices related to enhanced mobile broadband (eMBB) and ultra-reliable low-latency communications (URLLC) services. We formulate a network slicing planning optimization problem and model it as a mixed-integer linear programming (MILP) problem. Moreover, we develop an efficient price-and-branch algorithm (PBA) based on column generation (CG). This advanced optimization technique allows for overcoming the MILP model’s poor performance when solving larger network problem instances. Using extensive numerical experiments, we show the advantages of the PBA regarding the quality of the solutions obtained and the computation times, and analyze the packet-switched Xhaul network’s performance in various network slicing scenarios.
A Risk-Sensitive Intelligent Control Algorithm for Servo Motor Based on Value Distribution
Authors: Gao Depeng , Xiao Tingyu , Wang Shuai , Li Hongqi , Qiu Jianlin , Yang Yuwei , Chen Hao , Zhang Haifei , Lu Xi , Chen Shuxi
Published: June 2024

With the development of artificial intelligence, reinforcement-learning-based intelligent control algorithms, which generally learn control strategies through trial and error, have received more attention in the automation equipment and manufacturing fields. Although they can intelligently adjust their control strategy without the need for human effort, the most relevant algorithms for servo motors only consider the overall performance, while ignoring the risks in special cases. Therefore, overcurrent problems are often triggered in the training process of the reinforcement learning agent. This can damage the motors’ service life and even burn it out directly. To solve this problem, in this study we propose a risk-sensitive intelligent control algorithm based on value distribution, which uses the quantile function to model the probability distribution of cumulative discount returns and employs the condition value at risk to measure the loss caused by overcurrent. The agent can accordingly learn a control strategy that is more sensitive to environmental restrictions and avoid the overcurrent problem. The performance is verified on three different servo motors with six control tasks, and the experimental results show that the proposed method can achieve fewer overcurrent occurrences than others in most cases.
Activated Carbon from Coconut Shells as a Modifier of Urea–Formaldehyde Resin in Particleboard Production
Authors: Kawalerczyk Jakub , Dukarska Dorota , Antov Petar , Stuper-Szablewska Kinga , Dziurka Dorota , Mirski Radosław
Published: June 2024

Various methods for the effective modification of urea–formaldehyde (UF) adhesives, aimed at enhancing the performance of wood-based materials, have been continually explored worldwide. The aim of this work was to investigate and evaluate the effect of introducing small amounts (0.25–1.5%) of activated carbon from coconut shells (ACCS) in UF adhesive on the properties of particleboard. The performed investigations of the adhesive mixture’s properties showed an increase in both viscosity and reactivity. Moreover, the use of loadings of 0.75% and 1% had a positive effect on mechanical properties such as bending strength, modulus of elasticity, and internal bond. In these variants, a delay in the degradation of the adhesive bonds by water was also observed, as indicated by the lower thickness swelling values measured after 2 h. However, under long-term exposure to water, the modification had no considerable effect on the dimensional stability of the boards. Markedly, the addition of 1 and 1.5% of ACCS resulted in a reduction in formaldehyde content, which can be attributed to the excellent adsorption capacity of activated carbon. Overall, a loading of 1% was found to be optimal, resulting in improved strength, enhanced water resistance, and reduced formaldehyde content.
Plasma Uric Acid, Lactate, and Osmolality in Colorectal Cancer
Authors: Kiselova-Kaneva Yoana , Vankova Deyana , Kolev Nikola , Kalinov Turgay , Zlatarov Alexandar , Komosinska-Vassev Katarzyna , Olczyk Pawel , Yaneva Galina , Slavova Svetla , Ivanov Krasimir , Ivanova Diana
Published: June 2024

A complex evaluation of colorectal cancer (CRC) in relation to screening, diagnosis, stage determination, prognosis, and treatment requires valuable biomarkers. The aim of this study was to measure selected biomarkers—uric acid (UA), lactate, Na+, Cl−, and osmolality—in CRC patients and to assess their diagnostic value to distinguish between CRC and healthy controls. Plasma lactate (2.21 ± 0.11 vs. 2.88 ± 0.19, p < 0.01), Na+ (130.79 ± 0.42 vs. 133.23 ± 0.25, p < 0.001), Cl− (102.59 ± 0.45 vs. 103.94 ± 0.23, p < 0.01), and osmolality (266.44 ± 0.86 vs. 271.72 ± 0.62, p < 0.001) were found to be significantly lower in CRC patients as compared to the healthy controls group. Among them, with satisfactory diagnostic potential, were plasma Na+ concentrations and osmolality (AUCNa+ = 0.752, p < 0.0001; AUCosmolality = 0.757, p < 0.05), respectively. UA concentrations were detected at higher concentrations in CRC patients (333.67 ± 13.05 vs. 295.88 ± 13.78, p < 0.05). The results of this study contribute to the elucidation of molecular mechanisms of CRC pathogenesis and the role of studied metabolic parameters in this process. Plasma uric acid, lactate, and osmolality parameters can be used for screening and monitoring colorectal cancer. Further studies are required to elucidate the molecular mechanisms of their action in cancer development. The action of circulating plasma lactate may be different from those locally produced in the tumor microenvironment.
Small Area Estimation under Poisson–Dirichlet Process Mixture Models
Authors: Qiu Xiang , Ke Qinchun , Zhou Xueqin , Liu Yulu
Published: June 2024

In this paper, we propose an improved Nested Error Regression model in which the random effects for each area are given a prior distribution using the Poisson–Dirichlet Process. Based on this model, we mainly investigate the construction of the parameter estimation using the Empirical Bayesian(EB) estimation method, and we adopt various methods such as the Maximum Likelihood Estimation(MLE) method and the Markov chain Monte Carlo algorithm to solve the model parameter estimation jointly. The viability of the model is verified using numerical simulation, and the proposed model is applied to an actual small area estimation problem. Compared to the conventional normal random effects linear model, the proposed model is more accurate for the estimation of complex real-world application data, which makes it suitable for a broader range of application contexts.
Stress Analysis of Electrochemical and Force-Coupling Model for Ternary Lithium-Ion Batteries
Authors: Shi Wei , Xu Ruofan , Han Changjiang , Sun Bingxiang , Chai Jin , Liu Jiachang , Jiao Xuewen , Xiong Jiale , Li Yinghao
Published: June 2024

The mechanical pressure that arises from the external structure of the automotive lithium battery module and its fixed devices can give rise to the concentration and damage of the internal stress inside the battery and increase the risks of battery degradation and failure. Commercial batteries cannot be disassembled, and the diffusion stress distribution at different times during discharge is notoriously difficult to determine. This paper, therefore, establishes the electrochemical force-coupling model based on the electrochemical and diffusion mechanics principles of batteries and studies the internal stress distribution of the battery under the diffusion stress of the electrode-material level and external pressure. Mainly driven by the electrochemical potential of the electrode particle diffusion stress stemming from the lithium-concentration difference inside and outside the particles, rupture is more likely to occur at the surface of the negative-electrode active particle at the end of discharge or the beginning of charging, as shown in simulation analysis. The variation in the volume of electrode material also leads to different stress and strain inside different areas, with the order of strain and stress being negative active material > negative collector fluid > positive active material > positive fluid. Therefore, huge stress and deformation will first cause the negative active particles to deviate from the fluid gradually and squeeze the diaphragm, resulting in mechanical failure accordingly.
The Role of Semaphorin 6D (Sema6D) in Non-Muscle-Invasive Bladder Cancer—A Preliminary Study on Human Plasma and Urine
Authors: Purpurowicz Piotr , Kaminski Tomasz W. , Kordan Władysław , Korzekwa Anna J. , Purpurowicz Zbigniew , Jabłonowski Zbigniew
Published: June 2024

The incidence of bladder cancer worldwide in the last three decades has been increasing in both men and women. So far, there is no established non-invasive bladder cancer biomarker in daily clinical practice. Semaphorin 6D (sema6D) is a transmembrane protein that belongs to the class VI semaphorins. The aim of this study was to evaluate for the first time the potential role of sema6D in bladder cancer. The study group consisted of 40 patients with non-muscle-invasive bladder cancer (NMIBC) and the control group of 20 patients without malignancies. There was a statistically significantly higher urinary sema6D concentration in patients than controls (p < 0.05) but no significant difference in plasma 6D. There were no statistically significant differences in urinary or plasma concentration of sema6D between low- or high-grade cancer and according to the tumor stage in TNM classification. There was a statistically significant negative correlation between plasma sema6D and age of patients (R = −0.6; p = 0.019). Plasma sema6D does not seem to be useful in the clinical practice at this point. However, the urinary sema6D concentration could potentially serve as a marker of NMIBC used for diagnostic purposes, monitoring, and early relapse detection or the assessment of the treatment efficacy. Urinary sema6D is probably not associated with the grading or staging of NMIBC, so it cannot be used for the prediction of disease prognosis.
Clinical Genetic Testing for Hearing Loss: Implications for Genetic Counseling and Gene-Based Therapies
Authors: Lee Nam K. , Uhler Kristin M. , Yoon Patricia J. , Santos-Cortez Regie Lyn P.
Published: June 2024

Genetic factors contribute significantly to congenital hearing loss, with non-syndromic cases being more prevalent and genetically heterogeneous. Currently, 150 genes have been associated with non-syndromic hearing loss, and their identification has improved our understanding of auditory physiology and potential therapeutic targets. Hearing loss gene panels offer comprehensive genetic testing for hereditary hearing loss, and advancements in sequencing technology have made genetic testing more accessible and affordable. Currently, genetic panel tests available at a relatively lower cost are offered to patients who face financial barriers. In this study, clinical and audiometric data were collected from six pediatric patients who underwent genetic panel testing. Known pathogenic variants in MYO15A, GJB2, and USH2A were most likely to be causal of hearing loss. Novel pathogenic variants in the MYO7A and TECTA genes were also identified. Variable hearing phenotypes and inheritance patterns were observed amongst individuals with different pathogenic variants. The identification of these variants contributes to the continually expanding knowledge base on genetic hearing loss and lays the groundwork for personalized treatment options in the future.
Limited Clinical Impact of Genetic Associations between Celiac Disease and Type 2 Inflammatory Diseases: Insights from Mendelian Randomization
Authors: Omar Mahmud , Omar Mohammad , Nassar Salih , Lahat Adi , Sharif Kassem
Published: June 2024

Background: Celiac disease, a gluten-triggered autoimmune disorder, is known for its systemic inflammatory effects. Its genetic associations with type 2 inflammatory diseases like asthma, allergic rhinitis, and atopic dermatitis remain unclear, prompting this study to explore their potential genetic interplay. Methods: Utilizing two-sample Mendelian randomization (TSMR), we examined the genetic associations using 15 genetic instruments from GWAS datasets. Our analysis focused on celiac disease and its relation to asthma, allergic rhinitis, atopic dermatitis, and IgE-mediated food allergies. A power analysis was conducted to determine the study’s detection capabilities, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using various MR methods. Results: Our Mendelian randomization analysis identified statistically significant genetic associations between celiac disease and several type 2 inflammatory diseases, although these were practically insignificant. Specifically, celiac disease was associated with a slight increase in the risk of atopic dermatitis (OR = 1.037) and a minor protective effect against asthma (OR = 0.97). The link with allergic rhinitis was statistically detectable (OR = 1.002) but practically negligible. Despite robust statistical confirmation through various sensitivity analyses, all observed effects remained within the range of practical equivalence (ROPE). Conclusions: Our study identifies potential genetic associations between celiac disease and certain type 2 inflammatory diseases. However, these associations, predominantly within the ROPE range, suggest only limited clinical implications. These findings highlight the need for cautious interpretation and indicate that further exploration for clinical applications may not be warranted at this stage.
Safety, Tolerability, and EEG-Based Target Engagement of STP1 (PDE3,4 Inhibitor and NKCC1 Antagonist) in a Randomized Clinical Trial in a Subgroup of Patients with ASD
Authors: Erickson Craig A. , Perez-Cano Laura , Pedapati Ernest V. , Painbeni Eric , Bonfils Gregory , Schmitt Lauren M. , Sachs Hannah , Nelson Meredith , De Stefano Lisa , Westerkamp Grace , de Souza Adriano L. S. , Pohl Oliver , Laufer Offir , Issachar Gil , Blaettler Thomas , Hyvelin Jean-Marc , Durham Lynn A.
Published: June 2024

This study aimed to evaluate the safety and tolerability of STP1, a combination of ibudilast and bumetanide, tailored for the treatment of a clinically and biologically defined subgroup of patients with Autism Spectrum Disorder (ASD), namely ASD Phenotype 1 (ASD-Phen1). We conducted a randomized, double-blind, placebo-controlled, parallel-group phase 1b study with two 14-day treatment phases (registered at clinicaltrials.gov as NCT04644003). Nine ASD-Phen1 patients were administered STP1, while three received a placebo. We assessed safety and tolerability, along with electrophysiological markers, such as EEG, Auditory Habituation, and Auditory Chirp Synchronization, to better understand STP1’s mechanism of action. Additionally, we used several clinical scales to measure treatment outcomes. The results showed that STP1 was well-tolerated, with electrophysiological markers indicating a significant and dose-related reduction of gamma power in the whole brain and in brain areas associated with executive function and memory. Treatment with STP1 also increased alpha 2 power in frontal and occipital regions and improved habituation and neural synchronization to auditory chirps. Although numerical improvements were observed in several clinical scales, they did not reach statistical significance. Overall, this study suggests that STP1 is well-tolerated in ASD-Phen1 patients and shows indirect target engagement in ASD brain regions of interest.
Examining the Efficacy and Safety of Combined Locoregional Therapy and Immunotherapy in Treating Hepatocellular Carcinoma
Authors: Bajestani Nojan , Wu Gavin , Hussein Ahmed , Makary Mina S.
Published: June 2024

More than 800,000 people worldwide are diagnosed with HCC (hepatocellular carcinoma) each year, with approximately 700,000 deaths alone occurring in that same year. Treatment of HCC presents complex therapeutic challenges, particularly in intermediate and advanced stages. LRTs such as transarterial chemoembolization (TACE) and ablations have been the mainstay treatment for early to intermediate-stage HCC, and systemic therapies are used to treat intermediate-late-stage HCC. However, novel literature describing combining LRT with systemic therapies has shown promising results. This review explores recent advances in both liver-directed techniques for hepatocellular carcinoma, including bland transarterial embolization, chemoembolization, radioembolization, and ablative therapies in conjunction as well as with systemic therapies, with a focus on combination therapies, patient selection, procedural technique, periprocedural management, and outcomes. Our findings suggest that LRT combined with systemic therapies is a viable strategy for improving progression-free survival and time to progression for patients with intermediate-to-late-stage HCC. However, further investigation is required to refine treatment protocols and define patient cohorts that would benefit the most.
Assessment of Pepper Robot’s Speech Recognition System through the Lens of Machine Learning
Authors: Pande Akshara , Mishra Deepti
Published: June 2024

Speech comprehension can be challenging due to multiple factors, causing inconvenience for both the speaker and the listener. In such situations, using a humanoid robot, Pepper, can be beneficial as it can display the corresponding text on its screen. However, prior to that, it is essential to carefully assess the accuracy of the audio recordings captured by Pepper. Therefore, in this study, an experiment is conducted with eight participants with the primary objective of examining Pepper’s speech recognition system with the help of audio features such as Mel-Frequency Cepstral Coefficients, spectral centroid, spectral flatness, the Zero-Crossing Rate, pitch, and energy. Furthermore, the K-means algorithm was employed to create clusters based on these features with the aim of selecting the most suitable cluster with the help of the speech-to-text conversion tool Whisper. The selection of the best cluster is accomplished by finding the maximum accuracy data points lying in a cluster. A criterion of discarding data points with values of WER above 0.3 is imposed to achieve this. The findings of this study suggest that a distance of up to one meter from the humanoid robot Pepper is suitable for capturing the best speech recordings. In contrast, age and gender do not influence the accuracy of recorded speech. The proposed system will provide a significant strength in settings where subtitles are required to improve the comprehension of spoken statements.
Silactins and Structural Diversity of Biosilica in Sponges
Authors: Ehrlich Hermann , Voronkina Alona , Tabachniсk Konstantin , Kubiak Anita , Ereskovsky Alexander , Jesionowski Teofil
Published: June 2024

Sponges (phylum Porifera) were among the first metazoans on Earth, and represent a unique global source of highly structured and diverse biosilica that has been formed and tested over more than 800 million years of evolution. Poriferans are recognized as a unique archive of siliceous multiscaled skeletal constructs with superficial micro-ornamentation patterned by biopolymers. In the present study, spicules and skeletal frameworks of selected representatives of sponges in such classes as Demospongiae, Homoscleromorpha, and Hexactinellida were desilicified using 10% HF with the aim of isolating axial filaments, which resemble the shape and size of the original structures. These filaments were unambiguously identified in all specimens under study as F-actin, using the highly specific indicators iFluor™ 594-Phalloidin, iFluor™ 488-Phalloidin, and iFluor™ 350-Phalloidin. The identification of this kind of F-actins, termed for the first time as silactins, as specific pattern drivers in skeletal constructs of sponges opens the way to the fundamental understanding of their skeletogenesis. Examples illustrating the biomimetic potential of sophisticated poriferan biosilica patterned by silactins are presented and discussed.
Eco-Anxiety and Morita Therapy—A Review and Illustrative Case Report
Authors: Raile Paolo
Published: June 2024

Eco-anxiety, a growing psychological concern, affects an increasing number of individuals distressed about environmental degradation and climate change. Morita therapy, a psychological approach developed in Japan, that emphasizes acceptance and action has potential applicability for treating modern anxieties such as eco-anxiety. An illustrative case report focusing on Waltraud M., a 29-year-old legal professional experiencing eco-anxiety is used as an example for the basis of exploring eco-anxiety in general and Morita therapy more specifically. The therapeutic intervention was conducted over several months, and the progress was documented through therapeutic diary entries, which detailed her emotional state and actions. Waltraud reported significant improvements in managing her anxiety. Initially overwhelmed by her ecological concerns, she learned to channel her anxieties into positive actions, such as making lifestyle adjustments that align with her environmental values. Notably, her ability to focus on immediate actions rather than future uncertainties helped reduce her anxiety symptoms. Morita therapy proved beneficial in managing Waltraud’s eco-anxiety by facilitating a shift from passive worry to active engagement with life’s challenges. The therapy’s focus on accepting emotions as they are, without trying to change them, and prioritizing meaningful action was effective in reducing the psychological distress associated with eco-anxiety. While promising, these findings are based on a single case report, and further research involving diverse populations and control groups is necessary to generalize the results and fully ascertain the therapy’s efficacy across different cultural and clinical settings.
The 22q11.2 Deletion Syndrome from A Biopsychosocial Perspective: A Series of Cases with an ICF-Based Approach
Authors: Cabral Ana Paula Corrêa , Horovitz Dafne Dain Gandelman , Santos Lidiane Nogueira , Carvalho Amanda Oliveira de , Wigg Cristina Maria Duarte , Castaneda Luciana , Simon Liane , Ribeiro Carla Trevisan Martins
Published: June 2024

The 22q11.2 deletion syndrome (DS) can have a significant impact on functionality. The purpose was to describe 22q11.2DS children with functioning from a biopsychosocial perspective, focusing on the impact of children’s health condition from domains of the International Classification of Functioning, Disability, and Health (ICF). Methods: A descriptive, cross-sectional case series study with seven 22q11.2DS children. A questionnaire with an ICF checklist for 22q11.2DS was completed using a structured interview. The Wechsler Abbreviated Scale of Intelligence (WASI) was used to determine the Intelligence Quotient (IQ). Results: Seven participants from 7 to 12 years old, presented some level of IQ impairment. It was observed that 22q11.2DS children experience significant intellectual, cognitive, and speech impairments across ICF Body Function domains. Impairments related to nose and pharynx were found in only one patient. The most relevant categories considered limitations in the Activity and Participation components pertained to producing nonverbal messages, communication, handling stress, and social interaction. Family, health professionals, and acquaintances were perceived as facilitators in the component Environmental Factors. Conclusion: The sample has its functioning affected by aspects that go beyond impairments in body structure and function. The organization of information from the perspective of the ICF is a different approach that helps clinical reasoning.
The Role of Parental Mediation and Age in the Associations between Cyberbullying Victimization and Bystanding and Children’s and Adolescents’ Depression
Authors: Wright Michelle F.
Published: June 2024

Background/Objectives: The primary objective of this research was to assess age differences in the associations between cyberbullying victimization and bystanding and depression among 234 elementary school students (4th and 5th graders; 51% female), 363 middle school students (6th to 8th grades; 53% female), and 341 high school students (9th to 12th grades; 51% female) as well as the moderating effect of parental mediation in these relationships. Methods: Participants completed self-report questionnaires on their cyberbullying victimization and bystanding, as well as depressive symptoms. Results: The findings revealed that high levels of instructive mediation buffered against depression associated with cyberbullying victimization and bystanding across all age groups, with the strongest effects found for middle school students. Lower levels of instructive mediation and higher levels of restrictive mediation increased the positive relationships between cyberbullying victimization and bystanding and depression. Co-viewing mediation did not moderate any of the associations. Conclusions: Parental mediation of technology use has the potential to alleviate the negative consequences associated with cyberbullying victimization and bystanding. The findings highlight the importance of tailoring prevention and intervention strategies to specific age groups and to parents.
“Preparation Is Key”: Parents’ and Nurses’ Perceptions of Combined Parent-Delivered Pain Management in Neonatal Care
Authors: Carlsen Misic Martina , Olsson Emma , Thernström Blomqvist Ylva , Ullsten Alexandra
Published: June 2024

Background: There is a knowledge-to-practice gap regarding parent-delivered pain management, and few studies have investigated parents’ and nurses’ participation in and acceptance of combined parent-delivered pain-alleviating interventions such as skin-to-skin contact (SSC), breastfeeding, and parental musical presence. This study investigated parents’ and nurses’ perceptions of and reflections on experiencing combined parent-delivered pain management. Methods: This qualitative study applies a collaborative participatory action research design using ethnographic data collection methods such as focus groups, video observations, and video-stimulated recall interviews with parents and nurses. Results: The results concern three main categories, i.e., preparation, participation, and closeness, as well as various sub-categories. Preparations were central to enabling combined parent-delivered pain management. Participation was facilitated by parental musical presence, in which parents shifted their attention toward their infant. Closeness and presence during neonatal care helped parents become active during their infant’s painful procedures. Parental lullaby singing created a calm and trusting atmosphere and after the procedure, both parents and nurses felt that they had successfully supported the infant through a potentially painful procedure. Conclusions: Mental and practical preparation is central to implementing combined parent-delivered pain management. When parents and nurses explored the interventions, they found the methods feasible, promoting self-efficacy and confidence in both parents and nurses.
Advancing Conservation Strategies for Native Eastern Highlands-Strain Walleye Sander vitreus in West Virginia: Insights from Genomic Investigations and Broodstock Screening
Authors: Johnson Andrew , Zipfel Katherine , Welsh Amy
Published: June 2024

Walleye, Sander vitreus, has several distinct genetic lineages throughout North America as a consequence of Pleistocene glaciation. Stocking walleye across genetic boundaries in the mid-20th century has led to the introduction of non-native strains that persist to this day. In West Virginia, the identification of the native Eastern Highlands strain led the West Virginia Division of Natural Resources (WVDNR) to employ broodstock screening to assist in the conservation of the native strain. To develop a baseline native ancestry prevalence in walleye populations throughout the state, 1532 broodstock were sampled across 17 sampling locations over a 6-year period. To evaluate the effectiveness of the current broodstock two-SNP qPCR assay protocol and identify whether more SNPs need to be implemented, 284 walleye were sequenced and ancestry-genotyped across 42 fixed SNPs between the two strains. When comparing the current protocol to the older microsatellite protocol, advancement in the ability to identify native-strain individuals was observed. Genotyping previously assigned walleye broodstock across multiple fixed SNPs revealed that the current ancestry assignment protocol, on average, assigned individuals that display 96% Eastern Highlands native ancestry to the native strain and accurately identified >93% of all pure Eastern Highlands walleye. Throughout the state of West Virginia, the New and Kanawha River systems contained a high prevalence of native ancestry, with the Ohio River and sampled impoundments displaying varying levels of ancestry. SNPs with >98% prevalence in individuals assigned to the Eastern Highlands strain were identified during the course of the study and can be implemented in future screening protocols. Our results highlight the utility of genomic approaches as tools to assist fisheries management goals and their capability to accurately identify native ancestry to assist in conservation efforts.
Safety and Effectiveness of a Novel Color Corrector Serum for Causing Temporary Changes to Tooth Shade: A Randomized Controlled Clinical Study
Authors: Pascolutti Mauro , Tomic Alex , Milleman Kimberly R. , Milleman Jeffery L. , Walsh Laurence J.
Published: June 2024

Tooth color is a major driver of facial esthetics. While permanent changes in tooth shade can be achieved by bleaching and restorations, there is a need for cosmetic products that can cause reversible color changes. This randomized controlled clinical study assessed the effectiveness and safety of a novel color-correcting product (Hismile™ V34 Color Corrector Serum™) versus a placebo (vehicle control lacking the color-change dyes). A single-center, randomized, controlled, examiner-blind, two-group, parallel design, single-use study design was followed. The test products were applied on a cotton bud for 30 s, and then, rinsed off. Tooth shade for maxillary central incisors was measured at baseline, immediately, and at 30 and 60 min, using the Vita Bleachedguide 3D-Master® Shade Guide and the EasyShade Advanced 4.0 spectrophotometer (for determining values of L*a*b*). The subjects (N = 60) had a baseline shade of 1M2 (rank 9) or darker. A single application of the test product resulted in an immediate and significant (p < 0.001) three shade improvement (26.2%) according to the shade guide, and the same significant benefits extended to 30 and 60 min. The placebo product did not alter tooth shade (p = 0.326). These changes were accompanied by significant improvements in the L value (whiteness) up to 30 min, and a reduction in b* (yellowness) for up to 60 min. Two-thirds of subjects using the test product stated in a survey that their teeth appeared both whiter and brighter. No safety issues arose from the use of the test product or vehicle control. These results indicate that using a color corrector can achieve worthwhile changes to tooth shade for up to 60 min.
Effect of Different Graft Material Consistencies in the Treatment of Minimal Bone Dehiscence: A Retrospective Pilot Study
Authors: Menini Maria , Canullo Luigi , Iacono Roberta , Triestino Alessio , Caponio Vito Carlo Alberto , Savadori Paolo , Pesce Paolo , Pedetta Andrea , Guerra Fabrizio
Published: June 2024

Among different therapeutic strategies proposed in the case of bone volume deficit, guided bone regeneration (GBR) is a consolidated surgical procedure. The objective of this study is to retrospectively evaluate the behavior of two bone grafts with different consistencies in the GBR procedure by measuring the volumetric tissue changes 1 year after surgery. For this retrospective analysis, 25 cases of GBR with simultaneous implant insertion were selected. A total of 13 were grafted with a porcine cortico-cancellous bone mix (CCBM group), and 12 were grafted with a pre-hydrated granulated cortico-cancellous bone mix of porcine origin blended with 20% TSV gel (Collagenated-CCBM). A collagen membrane was fixed to cover the bone defect. A total of 42 implants were placed with computer-guided surgery. Preoperative and 12-month postoperative digital impressions were used to evaluate dimensional changes. Student’s t-test used for independent samples showed no statistically significant differences between the integrated distance (p = 0.995) and mean distance (p = 0.734). The mean integrated distance in the CCBM group was 41.80 (SD. 101.18) compared to a mean of 42.04 (SD. 66.71) in the Collagenated-CCBM group. Given the limitations of this study, in patients with peri-implant bone dehiscence, simple heterologous and collagenated heterologous cortico-cancellous bone grafts are suitable for filling the bone defect to promote bone regeneration, although further studies are needed.
Implementation of Patient-Individualized 3D-Printed Models in Undergraduate Students’ Education for Various Prosthetic Treatments: A Cross-Sectional Survey Study
Authors: Klink Andrea , Engelskirchen Fabian , Kaucher-Fernandez Pablo , Huettig Fabian , Roehler Ariadne
Published: June 2024

Background: Due to rapid changes in dental practice, digital technologies have become prominent in undergraduate dental education at German universities in recent years. This shift has prompted a re-evaluation of content as well as teaching methods, particularly in courses where students are prepared for patient treatment. Traditional training on standardized models with resin teeth cannot cover the complexity of individual dental arch configuration encountered in patient situations. This study explores the use of 3D printing technology to create individualized models for prosthetic treatment simulations, aiming to evaluate students’ feedback towards their experience with this training setting. Methods: First, the study describes the design and fabrication of individualized models with exchangeable teeth based on intraoral scans, mounted on connected plates with distance holders that can be fixed to standard phantom heads. Second, students provided feedback through a questionnaire, assessing various aspects such as the effectiveness of the 3D-printed models compared to traditional frasaco models for preparation exercises. Results: The results indicated that the design of the realized models was feasible for preparation training (question no. 4: 93% positive rating) and showed positive perceptions of the 3D-printed models, with students finding them effective for preparation exercises and beneficial in bridging the gap between simulation and real patient situations (question no. 6: 69% positive rating). Conclusions: The study suggests that 3D printing technology offers a valuable tool in dental education, providing realistic and patient-specific scenarios for students to enhance their skills and readiness for clinical practice. Further improvements in material properties in hand with cost-effective approaches are essential for widespread implementation.
A First Exploration of the Ts/VI “Analytical Triangle” Technique with UAV Imagery for Deriving Key Surface Energy Balance Parameters at Very High Spatial Resolution
Authors: Petropoulos George P. , Detsikas Spyridon E. , Kalogeropoulos Kleomenis , Pavlides Andrew
Published: June 2024

Knowledge on the spatiotemporal patterns of surface energy balance parameters is crucial for understanding climate system processes. To this end, the assimilation of Earth Observation data with land biosphere models has shown promising results, but they are still hampered by several limitations related to the spatiotemporal resolution of EO sensors and cloud contamination. With the recent developments on Unmanned Aerial Vehicles (UAVs), there is a great opportunity to overcome these challenges and gain knowledge of surface energy balance parameters at unprecedented resolutions. The present study examines, for the first time, the ability of an inversion-modeling scheme, the so-called “analytical triangle” method, to retrieve estimates of surface energy fluxes and soil surface moisture (SSM) at high spatial resolution using UAV data. A further aim of our study was to examine the representativeness of the SSM estimates for the SM measurements taken at different depths. The selected experimental site is an agricultural site of citrus trees located near the city of Palermo on 30 July 2019. The results of comparisons showed that the sensible and latent heat fluxes from UAV were consistent with those measured from the ground, with absolute differences in comparison to ground measurements being 5.00 Wm−2 for the latent heat (LE) flux and 65.02 Wm−2 for H flux, whereas for the daytime fluxes H/Rn and LE/Rn were 0.161 and 0.012, respectively. When comparing analytical triangle SSM estimates with SM measurements made at different depths, it was found that there was a gradual increase in underestimation with increasing measurement depth. All in all, this study’s results provide a credible demonstration of the significant potential of the technique investigated herein as a cost-effective and rapid solution for estimating key parameters characterizing land surface processes. As those parameters are required by a wide range of disciplines and applications, utilization of the investigated technique in research and practical applications is expected to be seen in the future.