bluuebunny/crossref_metadata_2025 huggingface dataset:
Elucidating the Key Biomarkers and Immune Infiltration in Acne by Integrated Bioinformatics Analysis
Authors: Yang Lu , Shou Yan-hong , Yang Yong-sheng , Xu Jin-hua
Published: February 2021

Background

Acne vulgaris is a common inflammatory condition of skin. However, the landscape of immune infiltration in acne has not been entirely described.
Objectives

This study used a bioinformatics approach to investigate the inflammatory acne-related key biomarkers and signaling pathways, and immune infiltration in the acne lesion.
Methods

Two microarray datasets (GSE108110 and GSE53795) were downloaded from Gene Expression Omnibus. We used “limma” package from R software to identify the differentially expressed genes (DEGs) and perform the functional enrichment analyses. Then we built a protein-protein interaction network (PPI), performed the hub genes’ identification through STRING and Cytoscape. We applied the CIBERSORT algorithm to describe the immune infiltration in acne, and explored the correlation between biomarkers and immune infiltration. In the end, our findings in the study were verified by analyzing microarray dataset GSE6475.
Results

The differentially expressed genes (DEGs) including 292 upregulated genes and 150 downregulated genes in acne compared with non-lesional skin. The hub genes FPR1, C3AR1, CXCL1, CXCL8, FPR2, C3, CCR7, ITGB2 and pivotal pathways JAK-STAT signaling pathway, Toll-like receptor and NOD-like receptor signaling pathway were the most significantly associated with raising neutrophils, monocytes, activated mast cells, as well as reducing resting mast cells and Tregs.
Conclusions

Our study provides new insights into the pathogenesis and the targets which might be immunomodulatory potential for acne.
ZnO Nanoparticles Alter Redox Metabolism of Limnoperna Fortunei
Authors: Girardello Francine , Leite Camila Custódio , Touguinha Luciana Bavaresco , Roesch-Ely Mariana , Fernandes Andreia Neves , de Oliveira Richard Macedo , Borges Daniel L. G. , Silva Chrys Katielli Hoinacki da , Salvador Mirian , Villela Izabel Vianna , Henriques João Antonio Pêgas
Published: February 2021

Nanoparticles incorporated in consumer and industrial products cause concerns about their potential ecological impacts. Zinc oxide nanoparticles (ZnO-NP) have several applications, which increases their potential for release to the environment, causing ecotoxicological problems. Bivalve mollusks are susceptible targets for nanoparticles toxicity, since nanomaterials can enter the cells by endocytosis mechanisms. Limnoperma fortunei (golden mussel) are validated for biomonitoring purposes and have a wide distribution in the South of Brazil, where it can be collected throughout the year. The aim of this study was to evaluate the influence of ZnO-NP on the redox metabolism by enzymatic and non-enzymatic antioxidant defense assessment in addition to DNA damage by DNA fragmentation assay in L. fortunei after exposure to ZnO-NP. Adult bivalves were placed in contact with 1, 10, and 50 µg mL-1 ZnO-NP during three incubation times: 2, 4 and 24 h. Ionic Zn release, enzymatic and non-enzymatic antioxidant activity, oxidative damage to lipids and proteins and DNA damage were evaluated. Oxidative damage to proteins and lipids were observed after 4 h exposure and returned to baseline levels after 24 h. Superoxide dismutase levels decreased after 4 h exposure and increased after 24 h. No significant alteration was observed in catalase activity or even DNA double strand cleavage. The dissociation of ZnO may occur after 24 h, releasing ionic zinc (Zn2+) by hydrolysis, which was confirmed as the ionic Zn concentration increased following 24 h exposure. In conclusion, ZnO-NP were able to induce oxidative stress in exposed golden mussels. The golden mussel is capable to modulate its own antioxidant defences in response to oxidative stress and seems to be able to hydrolyse the nanoparticle and consequently release Zn2+ into the cellular compartment.
Determination of Possible Responses of Radon-222, Magnetic Effects, and Total Electron Content to Earthquakes on the North Anatolian Fault Zone, Turkiye: An ARIMA and Monte Carlo Simulation
Authors: Mohammed Dawar Hama Khalid , Külahcı Fatih , Muhammad Ahmad
Published: February 2021

Around the world, earthquake forecasting studies have become very important nowadays due to the increase in number of fatal earthquakes annually. This paper proposes to achieve a possible relationship between soil radon gas concentration and atmospheric Total Electron Content (TEC) during earthquakes taking into account magnetic effects on the North Anatolian Fault Zone (NAFZ) in Turkiye. The ARIMA and Monte Carlo Simulation (MCS) are employed for determining radon gas concentrations by taking into account magnetic effects as an innovative approach. In the study area relatively small and medium-scale earthquakes have taken place during the observation period. As a result of the investigations, the relationships between each of the parameters and earthquakes are determined, and hence, a good relationship is obtained between Rn gas anomaly and micro-seismic activity. In the ionosphere, geomagnetic activity has a primary impact and long duration on TEC distribution, but due to micro-seismic events it has rather small influence. The proposed ARIMA and MCS simulations to detect changes in soil Rn gas concentrations have significant results for detecting micro-seismic activity anomalies.
Surgical Challenges in Posterior Cervicothoracic Junction Instrumentation
Authors: Balestrino Alberto , Gondar Renato , Jannelli Gianpaolo , Zona Gianluigi , Tessitore Enrico
Published: February 2021

Objectives: The cervicothoracic junction (CTJ) is a region of the spine submitted to significant mechanical stress. The peculiar anatomical and biomechanical characteristics make posterior surgical stabilization of this area particularly challenging. We present and discuss our surgical series highlighting the specific surgical challenges provided by this region of the spine.Methods: We have analyzed and reported retrospective data from patients who underwent a posterior cervicothoracic instrumentation between 2011 and 2019 at the Neurosurgical Department of the Geneva University Hospitals. We have discussed C7 and Th1 instrumentation techniques, rods design, extension of constructs and spinal navigation.Results: 36 patients were enrolled. We have preferentially used lateral mass (LM) screws in the subaxial spine, pedicle screws (PS) in C7, Th1 and upper thoracic spine. We have found no superiority of 3D navigation techniques over 2D fluoroscopy guidance in PS placement accuracy, probably due to the relatively small case series. Surgical site infection was the most frequent complication, significantly associated with tumor as diagnosis.Conclusions: When technically feasible, PS represent the technique of choice for C7 and Th1 instrumentation although other safe techniques are available. Different rods constructs are described although significant differences in biomechanical stability still need to be clarified. Spinal navigation should be used whenever available even though 2D fluoroscopy is still a safe option. Posterior instrumentation of the CTJ is a challenging procedure but with correct surgical planning and technique it is safe and effective.
Childhood Obesity and Overweight in Uganda: Evidence From the Uganda Demographic Health Survey 2016
Authors: Sserwanja Quraish , Mutisya Linet M. , Olal Emmanuel , Musaba Milton W. , Mukunya David
Published: February 2021

Background: Childhood obesity is an emerging public health problem. Although previously a problem of high-income countries, low- and middle-income countries are now registering higher proportions of overweight and obese children. Studies in Africa have mainly focused on undernutrition among children. This paper explores the factors associated with childhood obesity and overweight in Uganda using data from the Uganda Demographic and Health Survey (UDHS) of 2016.Methods: We used Uganda Demographic and Health Survey (UDHS) 2016 data of 4,338 children less than five years. Multistage stratified sampling was used to select study participants and data were collected using validated questionnaires. We used multivariable logistic regression to determine factors associated with obesity and overweight among children under the age of five in Uganda.Results: The prevalence of overweight and obesity was 5.0% (217/4338) (95% CI: 4.3–5.6) with overweight at 3.9% (168/4338: 95% CI: 3.2–4.3) and obesity at 1.1% (49/4338: 95% CI: 0.8–1.5). Boys were more likely to be overweight or obese (adjusted odds ratio: aOR = 2.00; 95% CI 1.42–2.82) compared to girls. Furthermore, children from the Western region (aOR = 1.61; 95% CI 1.07–2.44) compared to those from the North, children below the age of 49 months and those with mothers who were overweight or obese (aOR = 3.36; 95% CI 1.53–7.34) were more likely to be obese or overweight compared to their counterparts who were above 48 months and those with underweight mothers respectively.Conclusion: The present study showed male sex, older age of the children, nutritional status of the mothers and region of residence were associated with overnutrition among under five children in Uganda.
The identification of pregnant women with renal colic who may need surgical intervention
Authors: Maomao He , Lei Ming , Xiaoting Lin , Xu Xiaolan , He Zhihui
Published: February 2021

Objectives: To analyze clinical data and stone-related factors to identify predictive factors for surgical intervention in pregnant women with renal colic. Methods: We conducted a retrospective review of 212 pregnant women presenting with renal colic between 1st January 2009 and 31st December 2019. Patients were grouped according to surgical intervention and a range of demographic, clinical, laboratory, and ultrasound data were obtained. Univariate and multivariate analyses identified a range of predictive variables for surgical intervention. In addition, we used receiver operating characteristic (ROC) curve analysis to evaluate the predictive power of our model and created a nomogram for clinical application. Results: Of the 212 patients presenting with acute renal colic in pregnancy, 100 patients (47.2%) underwent surgical intervention and 112 patients (52.8%) were treated conservatively. Univariate analysis identified significant differences between the two groups with regards to fever, the duration of pain, white blood cells (WBCs), C-reactive protein (CRP), ureteral stone size, hydronephrosis, and stone location. Multivariate analysis further identified a number of independent predictors for surgical intervention, including fever, a duration of pain ≥4 days, a ureteral stone size ≥ 8 mm, and moderate or severe hydronephrosis.Conclusions: We identified several independent predictors for surgical intervention for renal colic in pregnancy. Fever, a duration of pain ≥4 days, a ureteral stone size ≥8 mm, and moderate/severe hydronephrosis, play significant roles in predicting surgical intervention. Our nomogram can help to calculate the probability of surgical intervention in a simple and efficient manner. Prospective studies are now required to validate our model.
Exploring the acceptance of telehealth within palliative care: A Self-Determination Theory perspective.
Authors: Keenan Joseph , Rahman Rachel , Hudson Joanne
Published: February 2021

The aim of this paper was to explore potential divergence and convergence in relation to health care professionals’ and patients’ acceptability of the use of telehealth within palliative care provision through the lens of Self-Determination Theory.The research utilized a deductive qualitative approach utilizing semi-structured interviews to explore divergence and convergence between health care professionals’ preconceptions of the use of telehealth in palliative care and the lived experiences of patients accessing support in this manner. Semi-structured interviews were conducted with both professionals and patients to explore whether the barriers and benefits of telehealth perceived by professionals corresponded to the patient’s lived experience of utilizing the technology in their palliative care. Interviews were analyzed using a deductive thematic analysis.Professionals and patients identified that the use of telehealth could satisfy the need for autonomy, however this manifested in different ways. Greater divergence was apparent between patient and professional perceptions about how telehealth could satisfy the need for relatedness and competence needs. The findings of this paper highlight how professionals preconceived concerns about the use of telehealth in relation to providing supportive palliative care may not be realized when exploring the experiences of patients accessing services through this medium. This paper highlights the important role of psychological need satisfaction when considering acceptability of telehealth, and motivation to engage in the implementation of technologically driven health services.
Efficacy evaluation of methanolic extracts of Calpurnia aurea and Schinus molle plants against the cattle lice Linognathus vitulli
Authors: Abubeker Abdi , Assen Alula , Dhuguma Ararsa
Published: February 2021

Background
Ectoparasites of livestock in general and lice in particular pose serious economic losses to the farmer, the tanning industry, and the country as a whole. Although the treatment of ectoparasites have been attempted by various chemical agents, the efficacy of the agents hampered by the development of drug resistance. Thus, Ethnoveterinary botanicals are an alternative control strategy for being sustainable and ecologically sound. Thus, this study aims to evaluate the louscidal activity of crude methanolic extracts of Calpurnea aurea and Schinus molle plants against the cattle lice, Linognathus vituli using the in vitro Adult Immersion Test (AIT). Six graded concentrations of the crude extracts, 6.25, 12.5, 25, 50, 100 and 200 mg/ml, were tested at different time intervals, and temporal changes in tick viability were recorded for 24 hours.
Results
After 24hrs post-exposure, two higher concentrations (200 and 100 mg/ml) of C. aurea extract caused 100±0.0% and 96.6±3.3% lice mortality, whereas S. molle extract caused 90±5.7% and 83.3±3.3% mortality, respectively. Louscidal activity varies with the type of plant extract, concentration and exposure time. After 24 hours of exposure to the extracts, the highest mortality was recorded for extracts from C. aurea with LC50 values of 8.83 mg/ml compared to S.molle with LC50 values of 16.68 mg/ml.
Conclusions
The louscidal activity of the plant extracts increases with increasing exposure time and concentration as well. Thus, the plant extracts could be used against Linognatus vituli as a potential alternative for the control of lice.
Keywords: Calpurnea aurea, Ethnoveterinary, lice, Adult Immersion Test, Schinus molle
Early effects of inspiratory muscle training in critical patients submitted to mechanical ventilation: A study protocol for a randomised controlled trial
Authors: de Oliveira Franciele Borges , Mesquita Fabrício Olinda de Souza , de Medeiros Jéssica Mascena , Ribeiro Hálisson Alves , de Oliveira Paula Tamara Fonseca , Carvalho Rodrigo Gustavo da Silva
Published: February 2021

Background: Respiratory muscle weakness is one of the primary factors associated with difficulty of ventilatory weaning in critically ill patients. In this sense, inspiratory muscle training (IMT) is a possible facilitator of successful weaning. One of the devices used for IMT is the POWERbreathe®, because it provides a linear pressure load, with the possibility of gradual increments. The effectiveness of early IMT in this population is not yet well known. The aim of this study is to assess the effects of early IMT with a mechanical loading device on the weaning time of patients on invasive mechanical ventilation (primary outcome), respiratory muscle strength, length of stay in the intensive care unit and in the success rate of weaning (secondary outcomes).Methods: This randomised controlled trial, a single blind evaluation, will be conducted in the intensive care unit of a university hospital on 42 adults, who will be randomly and blindly categorised into the control group, comprising patients who undergo routine physical therapy only, and the training group, comprising patients who undergo routine physical therapy associated with IMT twice a day, with load adjusted daily at 50% of maximum inspiratory pressure, three series of 10 repetitions with one minute rest in between. Both groups will be assessed when patients are eligible for the study and before the ventilatory support withdrawal. Effects of the training will be analysed from the collected data using intention-to-treat analysis. Between-group differences will be measured using generalised estimating equations for data analysis.Discussion: Results of this trial will likely provide valuable new information on the effects of IMT on weaning time, respiratory muscle strength, length of stay in the intensive care unit and the success rate of weaning in critically ill patients.Registration: ClinicalTrials.gov, NCT03758573. 29th November 2018.
Network Biology led identification of critical miRNA modules for High Altitude hypoxia and their potential as dietary supplements
Authors: Gupta Apoorv , R Sugadev , Sharma Y K , Khurana Pankaj
Published: February 2021

Early ascent to high altitude can cause severe damage to body functions and may lead to many fatal high-altitude disorders. To cope up with such conditions, the human body undergoes physiological and biochemical changes in order to adapt to extreme environmental conditions at high altitudes. Several microRNAs (miRNAs), Transcription Factors (TFs), and genes have been studied separately for their role in early adaptive molecular responses. We hypothesize that network analysis of miRNA-TF-gene co-regulatory networks of circulatory miRNAs (CmiRNAs) which are differentially expressed at high altitudes could reveal a complex regulatory functional module that might be controlling molecular adaptive responses at high altitude. A comprehensive and non-redundant list of differentially expressed human CmiRNAs during high altitude ascent was collated and 470 Feed-Forward Loops (FFLs) tripartite motifs were identified in the miRNA-TF-gene co-regulatory networks. Network analysis and K-means clustering identified 11 biologically overrepresented FFLs regulated by 8 miRNAs hsa-miR-335-5p, hsa-miR-26a-1-3p, hsa-miR-210-3p, hsa-miR-193b-3p, hsa-miR-17-5p, hsa-miR-16-5p, hsa-miR-5582-5p and hsa-miR-130a-3p. Pathway enrichment identified metabolism and inflammation as important hallmark responses responsible for high altitude adaptation. These miRNAs were evaluated for their supplementation from dietary sources. Phylogenetic analysis with 4 other mammalian and non-mammalian species showed that Bos taurus (cattle) milk could be a possible source of these dietary miRNAs. Exogenous miRNAs bta-mir-16-1, bta-mir-130a, bta-miR-335, and bta-miR-210 have >95% of sequence similarity and could become potential dietary miRNAs candidates. The sequence, structural properties, and high AGO2 binding efficiency of all these exogenous miRNAs show good serum stability and cellular uptake possibility in the mammalian host. Bta-miR-210 with highest Minimal Folding free Energy Index (MFEI) and highest Atomic Contact Energy (ACE) with AGO2 has the best potential to be a dietary supplement.
Smart hospitals around the world: a systematic review
Authors: Rasoulian-Kasrineh Marjan , Sharifzadeh Nahid , Tabatabaei Seyyed-Mohammad
Published: February 2021

Background

It is almost impossible to think about a non-digital world today. digital technologies have changed our life style and they have also affected many domains including health domain. We are all aware that paper-based hospitals have changed a lot to be paper-less. Then a new term was born which is “smart hospital” and studies have been conducted in this field, so this study was designed to conduct a comprehensive review about smart hospitals.
Methods

741 studies were identified using unique keywords through searching in the PubMed, ScienceDirect, Embase and Scopus databases. Overall, after applying the inclusion and exclusion criteria (647 based on abstract title and 33 after reading full text) and removing duplicates (43), 18 studies were included in this review.
Results

Geographically, most of the articles were from Asia (50%). The highest number of publications were observed in 2012. A multidisciplinary team were involved in 77% of the researches and 61.12% of them were conducted in more than one research center. The majority of articles have been published in Q1 quality journals (33.34%) and high-income countries accounted for the largest percentage (66.67) of publishing smart hospital related articles. 27.78% of the studies were aimed at patient care, which had the highest percentage. Among the technologies used, RFID was the most and 66.67% of the articles came from researches about the implementation of a smart hospital.
Conclusions

it should be noted that development or implementation of a smart device in a hospital should not be considered as implementing a smart hospital, while many studies have used the term smart hospital in their study. Many Asian researchers have used the term “smart hospital” in their articles, but on the other hand, most of related articles published in Q1 journals were from America and Europe. Also, it was also observed that most studies focused on the two concepts including resource management and patient care.
Peptide OM-LV20 promotes structural and functional recovery of spinal cord injury in rats
Authors: Zhao Jian , Pang Ailang , Yang Meifeng , Zhang Xuemei , Zhang Rong , Liu Jingfei , Gu Yuanqi , Li Shanshan , Yin Saige , Hu Yan , Zhang Due , Ba Yingchun , Meng Buliang , Yang Xinwang
Published: February 2021

At present, there are no satisfactory therapeutic drugs for the functional recovery of spinal cord injury (SCI). We previously identified a novel peptide (OM-LV20) that accelerated the regeneration of injured skin tissues of mice and exerts neuroprotective effects against cerebral ischemia/reperfusion injury in rats. Here, the intraperitoneal injection of OM-LV20 (1 µg/kg) markedly improved motor function recovery in the hind limbs of rats with traumatic SCI, and further enhanced spinal cord repair. Administration of OM-LV20 increased the number of surviving neuron bodies, as well as the expression levels of brain-derived neurotrophic factor and its receptor tyrosine receptor kinase B. In the acute stage of SCI, OM-LV20 treatment also increased superoxide dismutase and glutathione content but decreased the levels of malonaldehyde and nitric oxide. Thus, OM-LV20 significantly promoted structural and functional recovery of SCI in adult rats by increasing neuronal survival and BDNF and TrkB expression, and thereby regulating the balance of oxidative stress. Based on our knowledge, this research is the first report on the effects of amphibian-derived peptide on the recovery of SCI and our results highlight the potential of peptide OM-LV20 administration in the acceleration of the recovery of SCI.
Polystyrene microplastics induce an immunometabolic active state in macrophages
Authors: Merkley Seth , Moss Harrison C , Goodfellow Samuel M , Ling Christina L , Meyer-Hagen Jewel L , Weaver John , Campen Matthew J , Castillo Eliseo F
Published: February 2021

Anti- and pro-inflammatory responses in macrophages are influenced by cellular metabolism. Macrophages are the primary phagocyte in mucosal environments (i.e., intestinal tract and lungs) acting as first-line defense against microorganisms and environmental pollutants. Given we now face extensive microplastic contamination of our food and water sources, we aimed to examine the metabolic response in macrophages to microplastic particles (MP). Utilizing murine macrophages, we assessed the metabolic response of macrophages after polystyrene MP phagocytosis. The phagocytosis of MP by macrophages induced a metabolic shift toward glycolysis and a reduction in mitochondrial respiration that was associated with an increase of cell surface markers CD80 and CD86 and cytokine gene expression associated with glycolysis. The gastrointestinal consequences of this metabolic switch in the context of an immune response remains uncertain but the global rise of plastic pollution and MP ingestion potentially pose an unappreciated health risk.
The Impact of Investment in Human Capital on Bank Performance: Evidence from Bangladesh
Authors: Akhter Bilkis , Rahman Md. Mominur
Published: February 2021

The objective of this study is to examine the aspects of investment in human capital like training of employees, education level of employees, knowledge level of employees, and skills of employees that influence the performance of a bank and to provide some comments to improve the banking sectors. This research included a conceptual model along with hypotheses. This empirical study is based on primary data. The data were obtained by the convenient sampling procedure with a questionnaire using the Seven Point Likert Scale. The hypothesized model has been validated using data from 261 participants and an analysis was conducted using the system of Structural Equation Modelings (SEM). The results revealed that investment in training, knowledge level and skills of the employee was positively connected to bank performance at less than 1% and a 5% level of significance. But, the employee's educational level does not substantially affect bank output in this analysis. The focus field is the study of the human capital investments of the Human Resources Division at Janata Bank Limited. It investigates different aspects of the Janata Bank’s facilities as well as the problems and prospects. Thus, this study can be a policy dialog for the managers, owners, decision-makers, and academicians.
Sustaining farmers life affected by the natural disaster; an implication during the covid-19 pandemic
Authors: Cyio Muhammad Basir , Anshary Alam , Mahfudz Mahfudz , Isrun Isrun , Napitupulu Mery , Fadhliah Fadhliah
Published: February 2021

Purpose This study aims to measure two investigate and identify effect of treatment factors: Organic Material and Triple Super Phosphate Fertilizer and also to study four main components: Extension (X1), Agricultural Production Facilities (X2), Government Assistance (X3), and Covid-19 dissemination (X4) information. Materials and methods The data collected through surveys and interviews include; (i) soil characteristics data and (ii) socio-economic conditions of farmers affected by the disaster and the Covid-19 pandemic. The statistical analysis used is Principal Component Analysis (PCA) using the Paleontological Statistics (PAST) application.Result and Discussion The result showed the M3 P3 treatment combination gave the highest effect: pH-H2O (6.13), P-total (52.28 mg/100g), P-available (28.62 ppm), plant dry weight (713.75 g/plot), P-uptake (0.58 g/plant), and Corncob (6.2 t/ha). The main component, the most effective factor to the successive variation X2 (PC-1) 75.55%; X3 (PC-2) 18.22%; and X4 (PC-3) 3.94%, while X1 (PC-4) did not result in variation (2.28%). The probability analysis showed farmers post-Earthquake income was affected by production facilities provisions (X2) p (0.015) < µ(0.05) and Government aid (X3) p (0.035) <µ(0.05) and amidst pandemic (X3) p (0.028) <µ (0.05) by government aid, with Correlation Value of each Jono Oge (R) 0.91 and Toaya (R) 0.64, indicating main component factor in Jono Oge is higher at (0.91) since land was displaced by Liquefaction while (0.64) in Toaya—the ground failure was by Earthquake.
TemplateFlow: a community archive of imaging templates and atlases for improved consistency in neuroimaging
Authors: Ciric Rastko , Lorenz Romy , Thompson William , Goncalves Mathias , MacNicol Eilidh , Markiewicz Christopher , Halchenko Yaroslav , Ghosh Satrajit , Gorgolewski Krzysztof , Poldrack Russell , Esteban Oscar
Published: February 2021

Neuroimaging templates and corresponding atlases play a central role in experimental workflows and are the foundation for reporting standardised results. The proliferation of templates and atlases is one relevant source of methodological variability across studies, which has been recently brought to attention as an important challenge to reproducibility in neuroscience. Unclear nomenclature, an overabundance of template variants and options, inadequate provenance tracking and maintenance, and poor concordance between atlases introduce further unreliability into reported results. We introduce TemplateFlow, a cloud-based repository of human and nonhuman imaging templates paired with a client application for programmatically accessing resources. TemplateFlow is designed to be extensible, providing a transparent pathway for researchers to contribute and vet templates and their associated atlases. Following software engineering best practices, TemplateFlow leverages technologies for unambiguous resource identification, data management, versioning and synchronisation, programmatic extensibility, and continuous integration. By equipping researchers with a robust resource for using and evaluating templates, TemplateFlow will contribute to increasing the reliability of neuroimaging results.
Dimensions of sexual violence in perimenopausal women: A Systematic review protocol
Authors: Hajifoghaha Mahboubeh , Alizadeh Shiva , Mokhlesi Samira , Dabiri Fatemeh
Published: February 2021

BackgroundViolence against women is a crisis in public health and breaking human rights. Women who are sexually abused suffer a lot of physical, psychological and emotional injuries. Sexual violence has more adverse outcomes for middle-aged women, their families and society.MethodsThe present study will be conducted to review the dimensions of sexual violence in perimenopausal women. In this study, published articles from 2010 to 2020 will be reviewed. For this purpose, the articles that have the inclusion criteria will be selected by searching in databases PubMed, Scopus, Web of Science, ProQuest, SID and, Magiran using appropriate keywords. Articles of systematic review, letters to the editor, abstracts, and clinical trials will be excluded. A STROBE checklist will be used to assess the quality of articles.DiscussionThis systematic review will be addressed sexual violence in perimenopausal women as well as demographic factors affecting the existence of sexual violence. The results can be a guide for health planners to reduce this social problem and solve the worries of this group of society by providing the counseling programs.Trial registration: The results of this study will be submitted to the journals a systematic article. Also, this protocol is registered in PROSPERO with number CRD42020191679.
Desgastes dentários em praticantes de exercícios físicos de musculação
Authors: Bessa Mariana Silva de , Jácome Erik Vinícius Martins , Santos Marquiony Marques dos , Pessoa Daniela Mendes da Veiga , Almeida Gilmara Celli Maia de , Moura Jamile Marinho Bezerra de Oliveira
Published: February 2021

Os desgastes dentários conhecidos como atrição, abfração, erosão e abrasão, são considerados alterações fisiológicas ou patológicas, levando em consideração seus fatores etiológicos. Desta forma, o presente estudo objetivou avaliar a frequência de desgastes dentários em praticantes de exercícios físicos de musculação do município de Caicó, Rio Grande do Norte e o conhecimento dos mesmos sobre estes desgastes. A amostra foi constituída por 260 praticantes de musculação de 5 academias do município e para a coleta dos dados utilizou-se questionários e exame clínico intraoral. Foi realizada análise descritiva dos dados e para avaliar a relação entre os desgastes dentários e as variáveis independentes foram utilizados os testes estatísticos: t de Student, Qui-quadrado de Pearson e Correlação de Pearson, considerando um nível de significância de 5%. A presença de pelo menos um tipo de desgaste foi observada em 78,9% dos praticantes de musculação. Destes, 65,8% tinham apenas um tipo de desgaste, 12,3% dois tipos e 0,8% três tipos. Dos desgastes dentários estudados, a atrição e a abfração foram os mais frequentes, sendo 80,9% e 15,8% respectivamente. Dos praticantes, 91,9% não tinham conhecimento sobre os desgastes dentários. Concluiu-se que com o avanço da idade, maior a frequência de atrição e abfração. A abfração foi mais frequente naqueles que praticavam musculação até 4 vezes na semana. A atrição e a abfração foram as lesões dentárias de desgaste mais desconhecidas, podendo implicar em deficiências na prevenção dessas lesões.
Exploring mentalizing in adolescents with anorexia nervosa and borderline personality disorder: A comparative study of psychiatric inpatients and healthy controls
Authors: Cortés-García Laura , Akça Ömer Faruk , Wall Kiana , Sharp Carla
Published: February 2021

Background:

Impaired mentalizing, i.e., difficulties in understanding oneself and others in terms of mental states, has been associated with the development of Anorexia Nervosa (AN), mainly among adults. However, few studies have addressed this question in clinical samples of adolescents with AN. Moreover, no study has explored mentalizing abilities among inpatient adolescents presenting with AN and Borderline Personality Disorder (BPD), despite their high comorbidity in a highly relevant age group.

Objective:

This study attempted, for the first time, to further examine differences in mentalizing abilities and to identify specific mentalizing impairments in different psychiatric inpatient groups and healthy adolescents.

Methods:

Using samples of female adolescents aged 12–17, comparison analyses were performed between psychiatric inpatient adolescents with AN (n = 44), BPD (n = 101), AN+BPD (n = 48), other psychopathology (n = 163) and healthy adolescents (n = 129). Structured and semi-structured clinical interviews, and two experimental tasks were administered to assess AN, BPD and mentalizing, respectively.

Results:

Comparison analyses showed that patients with BPD and other psychiatric disorders evidenced higher levels of hypermentalizing compared to healthy adolescents. Hypermentalizing was also reported among inpatients with AN+BPD, although to a lesser extent. BPD and AN scores were positively correlated with hypermentalizing responses.

Conclusions:

Our results suggest that hypermentalizing is a specific mentalization impairment in inpatient adolescents, particularly with BPD and both AN+BPD. Further investigation into the efficacy of mentalization based treatments for adolescents with BPD and AN+BPD is recommended. Prospective studies are needed to assess mentalizing using experimental tasks among adolescents with AN, taking into account the potential influence of temporality and severity of the disorders’ symptoms.
Probing many-body localization in a disordered quantum dimer model on the honeycomb lattice
Authors: Pietracaprina Francesca , Alet Fabien
Published: February 2021

We numerically study the possibility of many-body localization transition in a disordered quantum dimer model on the honeycomb lattice.
By using the peculiar constraints of this model and state-of-the-art exact diagonalization and time evolution methods, we probe both eigenstates and dynamical properties and conclude on the existence of a localization transition, on the available time and length scales (system sizes of up to N=108 sites).
We critically discuss these results and their implications.
Customer Loyalty as an Impact of Perceived Usefulness to Grab Users, Mediated by Customer Satisfaction and Moderated by Perceived Ease of Use
Authors: Maryanto Rakha Hendra , Kaihatu Thomas Stefanus
Published: February 2021

The development of Internet users in Indonesia increases quite rapidly each year. This phenomenon makes new online-based businesses increase. Even when the data show that Grab has got the market share in Indonesia, business competition is ubiquitous. The research analyzed the impact of perceived usefulness and customer satisfaction on customer loyalty in Grab users. It also studied the impact of perceived usefulness on customer satisfaction and the customer satisfaction (moderated by perceived ease of use) as a mediator between perceived usefulness and customer loyalty. Perceived usefulness and perceived ease of use were dimensions of the Technological Acceptance Model (TAM), which influenced the user's choice of application usage. The phenomenon of interest in the research was Grab, as an online-based business application on smartphones. The research used quantitative approach. About 204 samples from 250 respondents were obtained using purposive sampling with questionnaires in Surabaya. The measurement used the 7-category of the Likert scale and adapted from the previous researches. For data analysis, the research used Hayes’s PROCESS model 7, and the reliability and validity tests were also conducted. The results show that all hypotheses are supported. Perceived usefulness influences customer satisfaction and customer loyalty positively. Then, customer satisfaction and perceived ease of use can work well as the mediator and moderator. These results contribute to the strategy formulation for business sustainability by Grab or other online-based businesses.
A Socio-pragmatic Analysis of Selected Covid-19-related Utterances
Authors: John Emike Acheoah , Jega Garba Azika , Onyemariechi Okoh Gloria
Published: February 2021

This study is a socio-pragmatic analysis of selected utterances of interlocutors whose discourse subject is “Covid-19”. In using language, it is not enough to be grammatical; language use should be underpinned by contextual nuances because this is a good way of using language as actions that produce results or effects. Therefore, the analysis of the selected linguistic structures in this study is an investigation of linguistic competence demonstrated through lexical choices and speech act sequencing. The approach explored in the study is discursive and integrative; for example, instead of strictly listing the speech acts performed in each utterance, they are mentioned in terms of how they impinge on the on-going interaction. The study underscores who says “what?”, “how?” and “why?”. Although this study is mainly hinged on the Pragma-crafting Theory, Bach and Harnish’s [1] speech act taxonomy is explored in the classification of the speech acts performed in the utterances. On the whole, the study concludes that the socio-pragmatic use of language is underpinned by the psychological and situational context(s), and produces expected results due to speaker-hearer shared knowledge.
Religia jako radykalne dążenie do sensu w logoterapii Viktora E. Frankla
Authors: Michalski Karol
Published: February 2021

Pytanie o sens jest centralnym pytaniem logoterapii Frankla. Życie człowieka polega na sensownym urzeczywistnianiu się i, w razie potrzeby, na przezwyciężaniu kryzysu sensu, któremu służy logoterapia jako metoda psychoterapeutyczna. Religia jest dla Frankla niczym innym, jak radykalnym dążeniem do sensu. Wiara w sens, leżąca u podstaw dążenia do sensu, pozwala człowiekowi nie tylko poszukiwać go w każdej sytuacji, ale także umożliwia przetrwanie w obliczu cierpienia i życiowej katastrofy. Życie sensowne daje ostatecznie człowiekowi poczucie spełnienia, niezależnie od tego, jaki czeka go dalszy los.
Successful Weight Reduction in Metabolic Syndrome with a Hypocaloric Plant-Based Diet (Lacto-ovo-vegetarian Diet) with Exercise During an Educational Hospitalization: Report of Three Cases
Authors:   Division of Gastroenterology, Akita City Hospital, 4-30 Matsuoka-machi, Kawamoto, Akita City 010-0933, Japan, Chiba Mitsuro , Komatsu Masafumi , Watanabe Satomi , Daimon Yoko
Published: February 2021

The high prevalence of obesity is a global concern. However, obesity and inflammatory bowel disease have similarities in epidemiology, diet, and gut microbial dysbiosis. An omnivorous (westernized) diet replacement with a plant-based diet in inflammatory bowel disease achieved better outcomes in both the induction and quiescent phases. Educational hospitalization providing a plant-based diet was found effective in suppressing flare-up in ulcerative colitis. This case report was designed to assess whether a plant-based diet can reduce body weight in patients with obesity during educational hospitalization for a short period of two weeks. Three men with metabolic syndrome (55, 61, and 65 years old) were included in the study with body mass index ranging from 27.0 to 31.2 kg/m2 and visceral fat area between 94.7 and 128 cm2. In Japan, a body mass index of ≥25 is defined as obesity. A lacto-ovo-vegetarian diet with brown rice (1400 or 1100 kcal/day), a plant-based diet, was provided during hospitalization for around two weeks. Patients walked for about 1 h in a park daily during the hospitalization. All three patients showed weight loss: 2.9%, 6.1%, and 6.6% at discharge. A decrease in body mass index, waist circumference, and the visceral fat area was also observed. Restriction in total calories in the form of a plant-based diet and daily 1-hour walks through an educational hospitalization for two weeks effectively reduced body weight and improved obesity-related parameters. Thus, a plant-based diet could be an effective weight-loss diet.
Using a Clinical Workflow Analysis to Enhance eHealth Implementation Planning: Tutorial and Case Study
Authors: Staras Stephanie , Tauscher Justin S , Rich Natalie , Samarah Esaa , Thompson Lindsay A , Vinson Michelle M , Muszynski Michael J , Shenkman Elizabeth A
Published: February 2021

eHealth apps often fail to improve clinical outcomes due to poor integration with clinical workflow—the sequence and personnel needed to undertake a series of tasks for clinical care. Our central thesis is that eHealth interventions will be more effective if the clinical workflow is studied and taken into consideration for intervention implementation. This paper aims to provide an introductory tutorial on when and how to use a clinical workflow analysis to guide the implementation of eHealth interventions. The tutorial includes a step-by-step guide to conducting a clinical workflow analysis in planning for eHealth implementation. We began with a description of why a clinical workflow analysis is best completed before the implementation of eHealth interventions. Next, we described 4 steps needed to perform the clinical workflow analysis: the identification of discrete workflow components, workflow assessment, triangulation, and the stakeholder proposal of intervention implementation. Finally, we presented a case study of a clinical workflow analysis, which was conducted during patient visits of patients aged 11 or 12 years from 4 diverse pediatric or family medicine clinics to plan the implementation of a tablet-based app for adolescent vaccination. Investigators planning the implementation of new eHealth interventions in health care settings can use the presented steps to assess clinical workflow, thereby maximizing the match of their intervention with the clinical workflow. Conducting a prospective workflow study allows for evidence-based planning, identifying potential pitfalls, and increasing stakeholder buy-in and engagement. This tutorial should aid investigators in increasing the successful implementation of eHealth interventions.
A Depth Camera–Based, Task-Specific Virtual Reality Rehabilitation Game for Patients With Stroke: Pilot Usability Study
Authors: Xu Yangfan , Tong Meiqinzi , Ming Wai-Kit , Lin Yangyang , Mai Wangxiang , Huang Weixin , Chen Zhuoming
Published: February 2021

Background

The use of virtual reality is popular in clinical rehabilitation, but the effects of using commercial virtual reality games in patients with stroke have been mixed.

Objective

We developed a depth camera–based, task-specific virtual reality game, Stomp Joy, for poststroke rehabilitation of the lower extremities. This study aims to assess its feasibility and clinical efficacy.

Methods

We carried out a feasibility test for Stomp Joy within representative user groups. Then, a clinical efficacy experiment was performed with a randomized controlled trial, in which 22 patients with stroke received 10 sessions (2 weeks) of conventional physical therapy only (control group) or conventional physical therapy plus 30 minutes of the Stomp Joy intervention (experimental group) in the clinic. The Fugl-Meyer Assessment for Lower Extremity (FMA-LE), Modified Barthel Index (MBI), Berg Balance Scale (BBS) score, single-leg stance (SLS) time, dropout rate, and adverse effects were recorded.

Results

This feasibility test showed that Stomp Joy improved interest, pressure, perceived competence, value, and effort using the Intrinsic Motivation Inventory. The clinical efficacy trial showed a significant time-group interaction effect for the FMA-LE (P=.006), MBI (P=.001), BBS (P=.004), and SLS time (P=.001). A significant time effect was found for the FMA-LE (P=.001), MBI (P<.001), BBS (P<.001), and SLS time (P=.03). These indicated an improvement in lower extremity motor ability, basic activities of daily living, balance ability, and single-leg stance time in both groups after 2 weeks of the intervention. However, no significant group effects were found for the FMA-LE (P=.06), MBI (P=.76), and BBS (P=.38), while a significant group interaction was detected for SLS time (P<.001). These results indicated that the experimental group significantly improved more in SLS time than did the control group. During the study, 2 dropouts, including 1 participant who fell, were reported.

Conclusions

Stomp Joy is an effective depth camera–based virtual reality game for replacing part of conventional physiotherapy, achieving equally effective improvement in lower extremity function among stroke survivors. High-powered randomized controlled studies are now needed before recommending the routine use of Stomp Joy in order to confirm these findings by recruiting a large sample size.
Investigating the Ethical and Data Governance Issues of Artificial Intelligence in Surgery: Protocol for a Delphi Study
Authors: Lam Kyle , Iqbal Fahad M , Purkayastha Sanjay , Kinross James M
Published: February 2021

Background

The rapid uptake of digital technology into the operating room has the potential to improve patient outcomes, increase efficiency of the use of operating rooms, and allow surgeons to progress quickly up learning curves. These technologies are, however, dependent on huge amounts of data, and the consequences of their mismanagement are significant. While the field of artificial intelligence ethics is able to provide a broad framework for those designing and implementing these technologies into the operating room, there is a need to determine and address the ethical and data governance challenges of using digital technology in this unique environment.

Objective

The objectives of this study are to define the term digital surgery and gain expert consensus on the key ethical and data governance issues, barriers, and future research goals of the use of artificial intelligence in surgery.

Methods

Experts from the fields of surgery, ethics and law, policy, artificial intelligence, and industry will be invited to participate in a 4-round consensus Delphi exercise. In the first round, participants will supply free-text responses across 4 key domains: ethics, data governance, barriers, and future research goals. They will also be asked to provide their understanding of the term digital surgery. In subsequent rounds, statements will be grouped, and participants will be asked to rate the importance of each issue on a 9-point Likert scale ranging from 1 (not at all important) to 9 (critically important). Consensus is defined a priori as a score of 7 to 9 by 70% of respondents and 1 to 3 by less than 30% of respondents. A final online meeting round will be held to discuss inclusion of statements and draft a consensus document.

Results

Full ethical approval has been obtained for the study by the local research ethics committee at Imperial College, London (20IC6136). We anticipate round 1 to commence in January 2021.

Conclusions

The results of this study will define the term digital surgery, identify the key issues and barriers, and shape future research in this area.

International Registered Report Identifier (IRRID)

PRR1-10.2196/26552