bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Astaxanthin-Loaded Nanoformulations for Skin Targeting: Present Progress and Prospective Directions
Authors: Kaur Rajwant , Arora Vimal , Goswami Manish
Published: September 2024

This comprehensive review provides information on astaxanthin-loaded topical nanocarrier-
based formulations for targeted skin enhancement. Astaxanthin, a potent carotenoid derived from
microalgae, has garnered considerable attention for its multifaceted potential in skincare, particularly
when incorporated into nanocarriers. These nanocarriers, like nanoemulsions, micelles, hydrogels
and nanoparticles, have revolutionized the field of dermatology by providing innovative solutions to
overcome the limitations associated with astaxanthin's solubility and stability. Astaxanthin's exceptional
antioxidant properties, including its ability to neutralize free radicals within both lipid and
aqueous environments, make it a compelling bioactive ingredient for combatting oxidative stress, a
central contributor to skin aging and various dermatological conditions. The nanoscale size of these
carriers facilitates enhanced skin penetration, controlled release, and improved bioavailability,
thereby augmenting astaxanthin's therapeutic efficacy. This review meticulously explores the mechanistic
insights behind astaxanthin's enhanced delivery and its multifaceted benefits, including photoprotection,
anti-inflammatory effects, and wound healing properties. The diverse applications of
astaxanthin-loaded nanocarriers in skincare, spanning anti-aging formulations, UV protection, scar
healing, and wound repair, are elucidated. Safety considerations are also addressed, drawing from an
extensive analysis of preclinical and clinical studies. The review provides valuable insights into optimal
concentrations, formulation strategies, and regulatory aspects governing astaxanthin-loaded
nanocarriers in skincare products.
A Pharmacological Overview of Degarelix and Relugolix in Advanced
Prostate Cancer
Authors: Munavvir Muhammed , Zeeshan Mhaskar , Mujeeburahiman M
Published: September 2024

Prostate cancer (PCa) ranks the second most diagnosed cancers among men globally
and the sixth leading cause of cancer-related deaths. Advanced prostate cancer can be defined as
the recurrence after definitive therapies (radical prostatectomy or external beam radiotherapy) and
de novo metastasis (metastasis without prior treatment). Advanced PCa can be categorized as metastatic hormone sensitive prostate cancer (mHSPC), non-metastatic castration resistant prostate
cancer (nmCRPC), and metastatic castration resistant prostate cancer (mCRPC). Management of
advanced PCa often involves castration to reduce testosterone levels, which can be achieved by gonadotropin releasing hormone antagonists such as degarelix and relugolix. Degarelix is injectable
while relugolix is an orally administered form of GnRH antagonist. This review aims to explore
the latest pharmacological aspects of these drugs to inform treatment decisions for advanced PCa.
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome with Multiple Drugs (Leflunomide and Cefuroxime): A Case Report
Authors: Yadav Pooja , Rao Gopal Krishna , Rataboli Padmanabh V. , Gurav Shailendra S.
Published: September 2024

Background:

Adverse Drug Reactions (ADRs) are unexpected reactions to a medicine
administered in the correct manner and at the proper dosage. Drug Rash with Eosinophilia and
Systemic Symptoms syndrome (DRESS syndrome) is a Severe Cutaneous Adverse Reaction (SCAR)
type of ADR with complicated clinical features involving several organ systems of the
body; frequently involved organs are the liver, kidney, lungs, and other organs. Prompt recognition
and correct diagnosis, followed by withdrawal of the causative agent, can promote appropriate
treatment, accelerate recovery, and reduce the related morbidity and mortality.

Case presentation:

We have, herein, presented a case of a 42-year-old female with a history of leflunomide
intake for plantar fasciitis. The patient subsequently developed fever, gastrointestinal
tract disturbance, facial edema, liver injury, skin rash, hematologic abnormalities (eosinophilia),
hepatosplenomegaly, and lymph node enlargement. The probability of leflunomide-induced
DRESS syndrome was rated as “definite”, with seven scores graded by RegiSCAR. The suspected
causative agent was withdrawn, and the patient was managed symptomatically. Following her management
and discharge, she again encountered similar complaints after administration of the cefuroxime
tablet. The causality assessment of the reactions was done using the WHO-UMC scale
and Naranjo’s assessment scale, and a “probable” reaction was found for both drugs.

Conclusion:

The presented case contributes to the existing global literature regarding exceptional
clinical presentations. Leflunomide and cefuroxime drugs have the potential to cause DRESS syndrome.
Thus, they should be handled cautiously, and if such a reaction occurs, it should be reported
to the responsible authorities.
MGCN-PolyA: An Integrated Computational Framework for Predicting
Poly(A) Signals with Multiscale-gated Convolutional Networks
Authors: Zhuang Jujuan , Gao Wanquan , Huang Xinru , Chen Guoyan
Published: September 2024

Background:

The accurate recognition of the polyadenylation signal (PAS) from DNA
sequences is essential for understanding gene transcriptional regulation. A variety of machine learning-based computational methods have been developed to predict PAS in recent years; however,
their performance and their generalization ability are unsatisfactory. It is highly desirable to design
more preferable computational approaches for PAS prediction.

Methods:

In this work, we developed an integrated framework MGCN-PolyA for PAS prediction
across four species, including Homo sapiens, Bos taurus, Mus musculus, and Drosophila melanogaster. MGCN-Poly(A) benefits from the diversity of feature engineering and the effectiveness of
the model architecture. We combined features from different perspectives, such as word embedding, One-hot encoding, K-mer frequency, and Enhanced Nucleic Acid Composition (ENAC),
which complement each other and provide rich and comprehensive information for model learning.
In model architecture, MGCN-Poly(A) leverages a two-channel multi-scale gated convolutional
network to effectively learn high-level feature representations at different scales, and then combines
the statistical features to predict PAS using random forest algorithm. These designs not only speed
up network training, but also improves the generalization ability

Results:

The benchmarking experiments on the independent test datasets demonstrate that MGCNPolyA outperforms other state-of-the-art algorithms in identifying PAS. MGCN-PolyA has the
highest accuracy on all test datasets, and its excellent performance on cross-species validation also
demonstrates the robustness of our model.

Conclusion:

Extracting features from different perspectives is important for PAS recognition, and
the integration of DNNs and shallow machine learning algorithms can improve the model performance.
Chemical Identification of Purified Molecule (3-Ethyl-6,7-dihydroxy-2- phenyl-chromen-4-one) Prepared from Alpinia officinarum with Anti- Cryptococcus neoformans Potential
Authors: Nasr Samar , Mahmoud Yehia A.G. , Elsilk Sobhy E. , Salah Ahmed M. , Amin Basma H.
Published: September 2024

Background:

Plants contain a large number of molecules with various potentials, including antifungal impact. Cryptococcus neoformans (C. neoformans) is a yeast that causes Cryptococcosis infection in both immunocompromised and normal individuals worldwide.

Objective:

This study aimed to investigate the inhibitory impact of plant extracts on C. neofor-mans and perform purification of the most bioactive product for further chemical identifica-tion.

Methods:

The anti-C. neoformans potential of fourteen plants extracted by using various sol-vents, including water, methanol, and benzene, was tested. The most promising compound with anti-C. neoformans was purified. The minimal inhibitory level of the purified sub-frac-tion as compared to fluconazole as a standard drug was determined. The chemical identifica-tion of the purified product was carried out using FTIR, 1HNMR, elemental analysis, and Mass spectroscopy.

Results:

Alpinia officinarum (A. officinarum) methanolic extract has the highest antifungal impact on C. neoformans and showed an inhibition zone of 3.2±0.2 cm. The methanolic ex-tract was separated into 14 fractions, where the fifth fraction showed the highest activity. It was further separated into four sub-fractions that were tested to characterize the most promis-ing molecule with anti-C. neoformans impact, which was further chemically identified as 3-Ethyl-6,7-dihydroxy-2-phenyl-chromen-4-one. The purified product led to significant altera-tions in the ultra-structure of C. neoformans relative to the standard drug.
Antioxidant and Cytoprotective Effects of Different Compounds on Cyclophosphamide-induced Nephrotoxicity
Authors: Almeida Machado Dayane , Moreira de Castro Oliveira Natasha , Speroni Ceron Carla , Tavares do Vale Gabriel
Published: September 2024

Cyclophosphamide is a drug derived from nitrogenous mustards and is mainly indicated
for the anti-neoplastic clinic. When it is metabolized in the liver, it produces acrolein, a cytotoxic
metabolite capable of generating damage to the body. The oxidative, nitrative and nitrosative
stress are responsible for mediating this side effect since the toxicity of the drug induces the production
of reactive species of oxygen (ROS) and nitrogen (RNS). These radicals are unstable and
react with other molecules that can result in cellular lesions such as lipid peroxidation, enzymatic
inactivation, and excessive activation of pro-inflammatory genes, producing molecules such as
malonaldehyde (MDA) and nitric oxide (NO), representing oxidative stress markers. One of the
consequences of these mechanisms is nephrotoxicity. In contrast, some compounds have direct or
indirect antioxidante action, which are the objects of this study: gallic acid, aminoguanidine,
chrysin, hesperidine, naringin, morin-5'-sulfonic acid sodium salt and spirulina. All of them are responsible
for the nephroprotective activity when administered during experiments in vitro or in
vivo. Thus, this observational bibliographic research is characterized as qualitative descriptive and
explanatory, since it focuses on analyzing the antioxidant properties of compounds with possible
potentials to inhibit the nephrotoxicity induced by cyclophosphamide and describe the results, in
addition to clarifying the biochemical activities involved in the process.
Cría in vitro de reinas de la abeja Nannotrigona perilampoides (Cresson, 1878) (Hymenoptera: Apidae: Meliponinae): efecto del alimento, edad de las obreras y la esterilidad
Authors: Rubio Armando , Sánchez Guillén Daniel , Liedo Fernández José Pablo , Solórzano Gordillo Erik de Jesús
Published: September 2024

Las abejas sin aguijón tienen importancia ecológica, económica y cultural en las zonas tropicales, pero su uso para la polinización de cultivos es limitado debido a restricciones para su reproducción a gran escala. El desarrollo de técnicas para su reproducción masiva es crucial para su integración comercial en la agricultura. El objetivo de este trabajo fue determinar la cantidad óptima de alimento larval para la cría in vitro de reinas, el efecto de la edad de las obreras en la aceptación de estas reinas y la importancia de la esterilidad en la implementación de la cría de reinas in vitro de Nannotrigona perilampoides, una especie de abeja sin aguijón con potencial para la polinización de tomate en el sur-sureste de México. Larvas de primer estadio se colocaron en placas estériles de 96 pocillos, con 38, 40, 42, 44, 46 y 48 μl de alimento para larvas y se mantuvieron en condiciones controladas de laboratorio. Las reinas que emergieron se introdujeron en colonias de fecundación con obreras de tres configuraciones de edades, jóvenes, adultas y mixtas. La emergencia de reinas varió del 30 al 100% en función de las cantidades de alimento administradas y de las condiciones de esterilidad al momento de traslarve. La cantidad óptima de alimento para larvas osciló entre 40 y 42 μl, además de que el tamaño de las reinas correlacionó positivamente con la cantidad de alimento suministrado. Las reinas fueron aceptadas en todos los núcleos de apareamiento, y se observó oviposición en tres de ellos, correspondientes a las reinas de los tratamientos de 38, 42 y 44 μl. La edad de las obreras no tuvo efecto en la aceptación de reinas, incluso en tres núcleos se observaron reinas fisogástricas. Se obtuvo mayor emergencia en los tratamientos con las condiciones de esterilidad más estrictas. Estos resultados muestran la posibilidad de formación de colonias mediante la cría in vitro de reinas de N. perilampoides con la técnica desarrollada.
Parasitoides de Saissetia miranda (Cockerell & Parrott) (Hemiptera: Coccidae) en Higueras (Ficus carica L.) de Ramos Arizpe, Coahuila, México
Authors: Fuentes Guardiola Lucía Teresa , Rodríguez Vélez Beatriz , García-Martínez Oswaldo
Published: September 2024

La higuera Ficus carica L. tiene potencial para explotarse comercialmente en el norte de México, donde su cultivo se está expandiendo por la capacidad que tiene para adaptarse a lugares con baja precipitación y altas temperaturas. Entre las plagas que afectan a la higuera se encuentran las escamas, insectos que succionan savia, debilitan la planta, y por su biología son difíciles de controlar, causando pérdidas económicas. En un huerto comercial de higuera Black Mission ubicado en el Municipio de Ramos Arizpe, Coahuila, se detectaron hembras de Saissetia miranda (Hemiptera: Coccidae). Los ejemplares se recolectaron y se llevaron a laboratorio para esperar la emergencia de enemigos naturales. Se determinó un complejo de cinco especies de parasitoides: Scutellista caerulea (Hymenoptera: Pteromalidae), Metaphycus anneckei (Hymenoptera: Encyrtidae), Cheiloneurus sp. (Hymenoptera: Encyrtidae), Baryscapus sp. (Hymenoptera: Eulophidae) y Signiphora bifasciata (Hymenoptera: Signiphoridae); S. caerulea y M. anneckei se reportan por primera vez en el Estado de Coahuila. El porcentaje de parasitoidismo ejercido por el complejo fue de 54.9 a 72.9 como valores máximo y mínimo, con un promedio de 64.5, lo que indica un alto control natural.
Forecasting Kenya's public debt using time series analysis
Authors:   Department of Mathematics and Statistics, University of Embu, Embu, Kenya, Keraro Obwoge Frankline , Morris Zakayo Ndiku ,   Department of Mathematics and Statistics, University of Embu, Embu, Kenya, Kitavi Dominic Makaa ,   Department of Mathematics and Statistics, University of Embu, Embu, Kenya, Wanyonyi Maurice ,   Department of Mathematics and Statistics, University of Embu, Embu, Kenya
Published: September 2024

Accurately forecasting public debt is essential for developing countries like Kenya to maintain fiscal sustainability and economic stability. This study aimed to identify the best time series forecasting model for predicting Kenya's future public debt to help policymakers create effective fiscal reforms. The Autoregressive Integrated Moving Average (ARIMA) and Holt-Winters exponential smoothing models were tested due to their ability to handle complex patterns and seasonality in time series data. Public debt data from Kenya from 2001 to 2021 were analyzed, and both models were applied to the processed data. The ARIMA (0,2,1) model, which uses second-order differencing and a moving average component, was found to be the best model based on information criteria. The Holt-Winters additive method also showed good performance, adapting well to recent data and seasonal trends with optimized smoothing parameters. Both models produced forecasts that closely matched the actual debt figures for 2022 and 2023, with an error margin of only 0.73. Measures of accuracy, such as Mean Absolute Percentage Error (MAPE) and Mean Absolute Scaled Error (MASE), confirmed the reliability of the models, with ARIMA performing slightly better than Holt-Winters. While previous studies have looked at debt forecasting for Kenya, this research offers a thorough evaluation and comparison of two strong time series models. Unlike existing literature, this study provides a rigorous out-of-sample forecasting assessment, identifying the best approach for reliably predicting Kenya's debt. However, the study is limited by its focus on univariate time series models, which could be improved by including relevant external economic variables. The findings show that the ARIMA and Holt-Winters models are accurate tools for forecasting Kenya's public debt, helping policymakers to develop sustainable debt management strategies and fiscal reforms based on reliable future projections.
An Application of Excess Solar and Storage Capacity Optimization for Grid Services
Authors: Rusakov Maxim , Farhidi Faraz
Published: September 2024

This initiative aims to enhance the efficiency of utility demand response (DR) operations by coordinating and integrating behind-the-meter (BTM) photovoltaic systems (PV) and energy storage (ES) using innovative machine learning software applications embedded in a distributed control architecture. The project is in the process of creating distributed energy resource (DER) learning agents and optimization engine within a hierarchical and layered distributed control architecture (DCA). These components work together to leverage aggregated DERs, providing more adaptable and swiftly responsive grid services tailored to a customized grid services set (GSS). They exchange information to facilitate the analysis, optimization, and dispatch of DERs for grid services. This paper outlines the DER Aggregation Model and the functional requirements of the DER Aggregation Engine, which delineates how participating DER assets will be grouped or aggregated for involvement in each GSS grid service. Based upon, we develop optimized command sets—establishing forecasted energy prices and substation level loads—utilizing DER excess capacity targeting five grid services: peak load management, energy arbitrage, frequency regulation, voltage support, and phase balance. In the end, sample customers’ bills with and without grid services will be compared for benchmarking associated tariffs.Keyword Aggregation model; distributed energy resources; grid services; machine learning; optimization
The readability of online health infographics: a comparison between CDC and WHO (Preprint)
Authors: Huang Ren , Fu Xuejuan
Published: September 2024

BACKGROUND

Effective communication of health information involves clear messaging to ensure that readers comprehend and can easily apply behavioral recommendations. The purpose of this study was to evaluate the readability and understandability of online health infographics from the CDC and WHO to determine whether these infographics are written to the recommended reading levels.

OBJECTIVE

Online health infographics from graphic page on the CDC website (51 infographics) and WHO website (75 infographics) were included in the research. We conducted 6 readability tests which 3 tests focused on textual features and 3 tests focused on cognitive factors to ensure a comprehensive representation.

METHODS

We used the traditional readability formulas like Flesch Reading Ease, Flesch-Kincaid Grade Level and The SMOG Index which focused on textual features and formulas considered cognitive factors like ATOS, New Dale-Chall and Coh-Metrix to test the infographics readability. We compared the readability of online health infographics with general guidelines and the differences between the CDC and WHO.

RESULTS

We found that most online health infographics from the CDC and WHO exceed the general guideline. Specifically, online health infographics in WHO have better performance on readability formulars that focus on textural features and cognitive factors compared with CDC.

CONCLUSIONS

Both the CDC and WHO which provide health information to the public should be mindful of the textural features and cognitive factors of the online health infographics to improve the readability.

CLINICALTRIAL

No clinical trials.
Impact of war on the development and progression of chronic kidney disease among residents of frontline regions (Kharkiv): first results of Save Kidneys Study as part of the ISN Clinical Research Program
Authors: Chub O.I. , Bilchenko O.V. , Reshetniak S.O.
Published: September 2024

Chronic kidney disease (CKD) affects up to 10 % of adults worldwide. Since February 24, 2022, at least 12 million people that is equivalent to 27 % of the Ukrainian population of 44.1 million have fled their homes. However, according to the registry analysis across eight European countries, among 14,436 migrants who visited health clinics, only 1.5 % had CKD. Such low prevalence may mean that healthy people tend to leave the affected zones while the sicker and older individuals stay behind. Compared to the available data on the impact of natural disasters, information about the effects of armed conflict on patients with CKD is very limited. Therefore, the aim of the study is to evaluate the impact of war on CKD development and progression among people living in frontline regions (Kharkiv, Ukraine).
Under Three Heavy Mountains—Identity Construction and Subjectivity Struggle of Chinese Women Workers
Authors: Yu Linhao
Published: September 2024

This paper examines contemporary Chinese women workers, whose experiences have gained increasing attention as rural labor forces migrate to urban areas and China’s status as the “factory of the world” evolves. It utilizes Pun Ngai’s ethnography “Made in China” as the primary text, alongside supporting texts such as “Rural Women in Urban China” (Jacka, 2006), “The change of factory regime in China and its impacts on workers” (Zhao, 2010). This paper provides a detailed analysis of the construction of these workers’ identities and their struggle for subjectivity. Confronted with triple oppression, female workers navigate and reshape their identities amidst the tensions between urban and rural settings.
Фотометрическое определение азокрасителей на основе карбо- и гетероциклических альфа-­дикарбонильных соединений
Authors: Филенко И.А. , Бубело О.Н. , Боженкова С.С. , Полянская Н.А. , Ковальчукова О.В.
Published: September 2024

До недавнего времени синтетические органические красители считались микрозагрязнителями из-за их низких концентраций в окружающей среде, однако последние данные свидетельствуют о том, что загрязнение красителями становится все более серьезной проблемой. Производственный процесс, определение качественных показателей продукции и требования к охране окружающей среды требуют аналитического контроля. В статье описаны новые азокрасители на основе карбо- и гетероциклических альфа-­дикарбонильных соединений и приведены результаты их определения фотометрическим методом. Установлены оптимальные длины волн поглощения растворов соединений, удельные коэффициенты поглощения, пределы обнаружения и линейные диапазоны определения.
М. С. Вигдергауз – ученый, организатор науки, создатель самарской хроматографической школы. К 90 летию со дня рождения
Authors: Рыбакова Е.В.
Published: September 2024

В этом году исполняется 90 лет со дня рождения выдающегося ученого с мировым именем, организатора науки, создавшего самую мощную хроматографическую школу в нашей стране, а также популяризатора хроматографии – науки, которой Марк Соломонович Вигдергауз посвятил всю свою жизнь. Научные интересы М. С. Вигдергауза охватывают все области хроматографии: от теории и практики газовой хроматографии до разработки хроматографических процессов с использованием неидеальных элюентов, неподвижных фаз и трансклассификационных вариантов хроматографии, основанных на использовании фазовых переходов в неподвижной и подвижной фазах. Марк Соломонович активно внедрял газо-жидкостную (ГЖХ) и капиллярную хроматографию в аналитический контроль, развивал применение газовой хроматографии в неаналитическом контроле и в промышленных процессах. Под его руководством создан один из первых ЭВМ-банков данных величин хроматографического удерживания более двадцати тысяч органических веществ, предложен минимальный набор предпочтительных неподвижных фаз с учетом условной хроматографической полярности. М. С. Вигдергауз предложил метод двой­ного внутреннего стандарта и другие методы расчета хроматограмм. Исследования ученого внесли заметный вклад в разработку газохроматографических методов анализа нефти и нефтепродуктов.
Development of Scrapbook Learning Media in Indonesian Language Content for Class III Primary School
Authors: Pulungan Marwan , Laihat L. , Maharani Siti Dewi , Herdiana Berta , Safitri Mazda Leva Okta
Published: September 2024

Based on the results of pre-research activities through observations and interviews conducted by researchers in class III at SD Negeri 05 Indralaya, various problems in learning activities were revealed. Scrapbooking is an example of a very interesting still visual media, referring to the art of sticking photos or drawings on paper and turning them into creative works. This research aims to produce valid and effective learning media products. Media validity, teacher response, and student response to scrapbook learning media in Indonesian language content. The type of research used is Research and Development (R&D) with the ADDIE development model with five stages consisting of Analyze, Design, Develop, Implement, and Evaluate. The research subjects were 1 teacher and 15 students. Data collection was carried out based on the results of material expert and media expert validation sheets, teacher response questionnaire sheets student responses, interviews, and documentation. Validation from material experts with a score percentage of 96.42% which is categorized as very valid. Validation from media experts with a score percentage of 90.6% which is categorized as very valid. The teacher response questionnaire resulted in a percentage score of 100% which was categorized as very good. Student response questionnaire with 2 trials, namely the small group got a percentage result of 88.88% in the very good category, and the large group got a percentage result of 84.44% in the very good category. Thus, the product in the form of scrapbook learning media is valid and effective for use as a learning media.
The Effect of Economic Growth, London Interbank Offered Rate (LIBOR), Exchange Rates and Covid-19 Pandemic on Foreign Direct Investment in Indonesia Period 2009-2023
Authors: Hermaliza Mingga , Widayatsari Any , Kornita Sri Endang
Published: September 2024

This study examines the influence of Economic Growth, LIBOR, Exchange Rates, and the Covid-19 Pandemic on Foreign Direct Investment (FDI) in Indonesia from 2009 to 2023. A quantitative approach was used for analysis. The results reveal that, over the period studied, Economic Growth and LIBOR both have a positive but minimal impact on FDI in Indonesia. The Covid-19 Pandemic, represented as a dummy variable, shows a positive but statistically insignificant effect on FDI at a 5% significance level, though it has a significant impact at the 10% level. In contrast, Exchange Rates have a positive and significant effect on FDI.
Analisa Produktivitas Tenaga Kerja Terhadap Hasil Produksi Part BS-62632-60M00 Di PT. Putra Kemuning
Authors: Adhiansyah Muhammad Hilmy , Sukanta Sukanta
Published: September 2024

Dalam suatu perusahaan, terdapat beberapa aspek yang dapat meningkatkan profit salah satunya yaitu produktivitas. Pengukuran produktivitas mampu memperbaiki produktivitas dimasa yang akan datang dengan memperhatikan perhitungan seluruh input bahan baku, energi, tenaga kerja hingga modal yang digunakan di suatu perusahaan untuk menunjukkan produktivitas dari produk yang dihasilkan. Secara umum konsep produktivitas adalah suatu perbandingan antara keluaran (output) dan masukan (input) persatuan waktu. Dalam penelitian ini menggunakan teknik pengumpulan data observasi untuk mengamati hasil produksi dan jumlah tenaga kerja yang bekerja pada setiap harinya. Penelitian ini juga menggunakan teknik pengumpulan data dengan cara mewawancarai pihak-pihak perusahaan terutama pada bagian produksi di pt. Putra Kemuning. PT. Putra Kemuning adalah salah satu perusahaan manufaktur yang ada di Kabupaten Karawang yang bergerak dibidang stemping, assy welding, jig dan dies, automotive dan non automotive. Nilai produktifitas tenaga kerja di bagian produksi terhadap hasil produksi Bracket selama April sampai Juni 2021 di PT. Putra Kemuning sudah cukup baik karena didapat hasil perhitungan yang lebih dari 100% atau 1 (satu) di setiap bulannya. Sedangkan untuk nilai Produktivitas parsial tenaga kerja total selama setahun adalah 42,92% dengan nilai rata rata 14,2%. Dan seluruh faktor dikatakan produktif serta perusahaan tetap mendapatkan profit karena tidak ada nilai produktifitas dibawah 1 (satu).
Penerapan Maynard Operation Sequence Technique Untuk Membangun Knowledge Management System Pada CV XYZ (Studi Kasus: Katering Makanan Sehat)
Authors: Putri Zahrani Ayu Pratama , Nurmiati Evy
Published: September 2024

Perkembangan bisnis dan teknologi terjadi sangat cepat, pengetahuan merupakan salah satu kebutuhan utama bisnis untuk meningkatkan efisiensi proses bisnis. Pada penelitian ini, diimplementasikan sebuah desain inovasi sistem untuk meningkatkan efisiensi proses produksi melalui dokumentasi dan penyebaran pengetahuan yang lebih baik kepada seluruh karyawan CV XYZ. Sistem Manajemen Pengetahuan adalah bagian dari mengembangkan dan mempertahankan bisnis. Maynard Manipulation Sequence Technique (MOST) diperlukan untuk menerapkan sistem manajemen pengetahuan untuk meningkatkan efisiensi proses manufaktur sebagai teknik pengukuran kerja yang berfokus pada pergerakan objek. Strategi ini bertujuan untuk mencapai fungsi aplikasi yang sesuai dengan situasi perusahaan. Penelitian ini menghasilakan sebuah pengembangan KMS yang dapat membantu karyawan berbagi pengetahuan dengan baik dan mengurangi waktu yang diperlukan untuk menyelesaikan masalah, karena dapat menggunakan fitur-fitur seperti forum diskusi, berbagi pengetahuan, perpustakaan, acara dan profil proses produksi pada aplikasi.
Implementasi Web Augmented Reality Sebagai Alternatif Edukasi Sistem Tata Surya Menggunakan Google Model Viewer dan Javascipt
Authors: Pambudi Prio , Nurhayati Oky Dwi , Prasetijo Agung Budi
Published: September 2024

Augmented Reality merupakan teknologi yang menempatkan suatu gambar visual dari grafis komputer ke dunia nyata. Saat ini Augmented Reality banyak digunakan dalam berbagai bidang, salah satunya yaitu bidang pendidikan sebagai alternatif media pembelajaran. Berdasarkan penelitian, didapatkan hasil dengan kelayakan penggunaan Augmented Reality sebagai media pembelajaran sebesar 93,8% dalam kondisi valid. Salah satu pelajaran yang dirasa tepat untuk menerapkan teknologi Augmented Reality sebagai alternatif edukasi adalah mata pelajaran sains yaitu pada lingkup pengenalan Tata Surya. Berdasarkan latar belakang tersebut, didapatkan solusi untuk membuat Web Augmented Reality. Tujuan dari pembuatan Web Augmented Reality ini adalah untuk memberikan pembelajaran Tata Surya terhadap Siswa SD N 1 Baleraksa. Web Augmented Reality ini dibangun menggunakan bahasa pemrograman Javascript dan dikembangkan menggunakan metode Scrum. Metode pengembangan Scrum memiliki tiga tahap utama yaitu Perencanaan, Development, dan Project Closure. Web Augmented Reality diuji menggunakan 2 metode yaitu pengujian kotak hitam (blackbox), serta pra-uji dan pasca-uji. Berdasarkan hasil penelitian, didapatkan hasil pengujian kotak hitam seluruh fungsi berjalan sesuai dengan yang diharapkan. Pada pengujian pra-uji dan pasca-uji mendapatkan nilai pra-uji sebesar 46.5 dan nilai pasca-uji sebesar 67.8, sehingga dapat disimpulkan bahwa penggunaan Web Augmented Reality mampu memberikan pengaruh dalammeningkatkan pemahaman siswa mengenai Tata Surya.
Sentiment Analisis pada moda Transportasi BUS untuk Meningkatkan Kualitas Layanan pada Perusahaan Otobus Terendah
Authors: Saphari Asep , Goermanto Leonard
Published: September 2024

Transportasi BUS merupakan alat transportasi masal yang digunakan untuk berpindah dari satu tempat ke tempat lain atau dari satu kota ke kot lain dengan jumlah lebih dari satu penumpang. Kualitas layanan yang diberikan oleh masing-masing perusahaan penyedia layanan transportasi berbeda-beda. Proses evaluasi dan peningkatan layanan dibutuhkan untuk meningkatkan minat masyarakat dalam memilih moda transportasi dalam perjalanannya. Penggunaan metode algoritma K-Nearest Neighbor (KNN) dan Naive Bayes dapat digunakan untuk mengklasifikasikan perusahaan otobus yang ramai digunakan oleh masyarakat dalam melakukan aktifitas perjalanan dan memilih fasilitas terbaik pilihan masyarakat. Data yang digunakan merupakan data yang dikumpulkan melalui Pusat Data dan Informasi (PUSDATIN) DKI Jakarta yang terkoordinasi di terminal Pulogebang Jakarta Timur dan dengan survey yang disebarkan kepada masyarakat melalui media sosial. Dalam penelitian ini mendapatkan Accuracy 0.12, Macro Avg 0.02 dan Weight Avg 0.11 dengan jumlah data 2831.
Diversidad cultural en contextos educativos de territorios urbanos. Análisis desde un enfoque de educación intercultural en un estudio de caso en la ciudad de Pereira
Authors: Grueso Vanegas Clara Inés
Published: September 2024

Las reflexiones compartidas en este libro se derivan de una investigación institucional realizada en el marco de convocatoria interna de la Universidad Tecnológica de Pereira, que tuvo como propósito analizar, desde un enfoque de educación intercultural, las situaciones socioeducativas emergentes en un territorio urbano del municipio de Pereira, caracterizado por la diversidad étnica y cultural de su población, procedente de diferentes comunidades y lugares del espacio nacional, principalmente rurales. Se pueden identificar en este contexto educativo urbano, cuatro comunidades culturalmente diversas y de diferentes orígenes territoriales, además de aquella población de origen urbano pereirano. Una gran comunidad la constituyen las familias afrodescendientes oriundas de territorios localizados en el Chocó biogeográfico colombiano; la segunda comunidad está integrada por las familias procedentes de resguardos y asentamientos indígenas ubicados en los departamentos de Risaralda y Caldas; una tercera comunidad la constituyen las familias procedentes de territorios campesinos del departamento de Risaralda, entre otros departamentos; finalmente, encontramos un grupo minoritario integrado por familias migrantes venezolanas. Todas estas familias dan cuenta de la movilidad humana que recon- 9 figuran el territorio urbano y a su paso, dinamizan el contexto educativo de la institución que proporciona los servicios educativos a la población.
Los Imperios marítimos europeos
Authors: Del Valle Neil
Published: September 2024

Título: The European Seaborne EmpiresAutor: Gabriel Paquette.Año de Publicación: 2019Páginas: 312ISBN: 978-0-300-20515-2 Editorial: Yale University Press
En esta obra, el profesor Gabriel Paquette reafirma su experticia en el estudio de la historia internacional, analizando el rol clave del viejo continente en los dinámicos y, al mismo tiempo, complejos procesos de colonización. Este trabajo investigativo nos ofrece una interesante visión sobre el rol que ejercieron los imperios europeos (España, Holanda, Portugal, Inglaterra y Francia) en los procesos de colonización.
Aesthetic criteria in the evaluation of scientific theories: Transition from geocentrism to heliocentrism
Authors: Sreckovic Sanja
Published: September 2024

The text focuses on the role of aesthetic criteria in the evaluation and
acceptance of scientific theories. The first part of the text presents and
analyzes the theory of James McAllister. McAllister explains the role of
aesthetic criteria in science by appealing to aesthetic induction: based on
the empirical success of previously accepted scientific theories, scientists
project aesthetic value onto certain properties of those theories, such as
simplicity, symmetry, the possibility of visualization, etc. McAllister
cites the transition from geocentrism to heliocentrism as a case study in
the history of science that supports this phenomenon. After presenting and
analyzing McAllister?s theory, the author presents several objections both
to the explanation of the transition to heliocentrism through aesthetic
induction, and to the more general understanding of the formation of
aesthetic criteria in scientific practice.
Family History of Diabetes and Clinical Characteristics in Children at Diagnosis of Type 1 Diabetes—A Swedish Population-Based Study
Authors: Hedlund Emma , Tojjar Jasaman , Lilja Lisa , Elding Larsson Helena , Forsander Gun , Ludvigsson Johnny , Marcus Claude , Norström Fredrik , Persson Martina , Carlsson Annelie
Published: September 2024

OBJECTIVE

To compare the prevalence of parental diabetes between children with and without type 1 diabetes (T1D), and to compare clinical characteristics at diagnosis of T1D in children with, versus without, a family history of diabetes.

RESEARCH DESIGN AND METHODS

Parental diabetes among children with T1D was compared with a general population cohort. Clinical characteristics were compared by family history of diabetes in parents and grandparents of 3,603 children with T1D using relative risk (RR) and ANOVA.

RESULTS

Children with T1D more often had parents with type 2 diabetes (T2D) (RR 1.88; P < 0.001) than did children without diabetes. Children with T1D and a family history of T2D were more likely to be overweight or obese (P = 0.002).

CONCLUSIONS

A family history of T2D and being overweight may contribute to increased risk of T1D.
A Glycemic Threshold Above Which the Improvement of β-Cell Function and Glycemia in Response to Insulin Therapy Is Amplified in Early Type 2 Diabetes: The Reversal of Glucotoxicity
Authors: Retnakaran Ravi , Pu Jiajie , Ye Chang , Emery Alexandra , Harris Stewart B. , Reichert Sonja M. , Gerstein Hertzel C. , McInnes Natalia , Kramer Caroline K. , Zinman Bernard
Published: September 2024

OBJECTIVE

Alleviation of unrecognized glucotoxicity, with resultant recovery of β-cell function, could amplify the glucose-lowering effect of pharmacotherapy and contribute to the variable therapeutic response observed among patients with type 2 diabetes (T2D). However, clinical evidence supporting this concept is lacking. Short-term intensive insulin therapy (IIT) can ameliorate glucotoxicity and improve β-cell function in early T2D. Thus, for evidence of recovery of glucotoxicity-associated β-cell dysfunction, we sought to determine whether there exists a baseline fasting glucose threshold above which the post-IIT improvement in both β-cell function and glycemia is amplified.

RESEARCH DESIGN AND METHODS

IIT (glargine, lispro) was administered for 3 weeks to 108 adults with T2D (mean duration 1.8 ± 1.4 years). Oral glucose tolerance tests before and after IIT enabled assessment of β-cell function by Insulin Secretion-Sensitivity Index-2 and insulinogenic index/HOMA-insulin resistance. For each level of baseline fasting glycemia from 6.0 to 10.5 mmol/L, we modeled the difference in IIT-induced percentage change in β-cell function between those at/above the indicated glucose level and those below it.

RESULTS

The relationship between baseline fasting glucose and the differential change in β-cell function was nonlinear. Instead, this relationship was best fit by a cubic regression model with inflection (amplification) at fasting glucose at 9.3 mmol/L. Moreover, baseline fasting glucose at 9.3 mmol/L also identified the inflection point at which nonlinear reductions in fasting glucose and 2-h glucose, respectively, were both amplified.

CONCLUSIONS

The respective improvements in β-cell function and glycemia in response to short-term IIT are amplified in those in whom baseline fasting glucose exceeds a defined threshold, consistent with reversal of glucotoxicity.
A Glycemic Threshold above which the Improvement of Beta-cell Function and Glycemia in Response to Insulin Therapy is Amplified in early Type 2 Diabetes:The Reversal of Glucotoxicity
Authors: Retnakaran Ravi , Pu Jiajie , Ye Chang , Emery Alexandra , B Harris Stewart , M Reichert Sonja , C Gerstein Hertzel , McInnes Natalia , K Kramer Caroline , Zinman Bernard
Published: September 2024

OBJECTIVE: Alleviation of unrecognized glucotoxicity, with resultant recovery of beta-cell function, could amplify the glucose-lowering effect of pharmacotherapy and contribute to the variable therapeutic response observed amongst patients with T2DM. However, clinical evidence supporting this concept is lacking. Short-term intensive insulin therapy (IIT) can ameliorate glucotoxicity and improve beta-cell function in early T2DM. Thus, for evidence of recovery of glucotoxicity-associated beta-cell dysfunction, we sought to determine whether there exists a baseline fasting glucose threshold above which the post-IIT improvement in both beta-cell function and glycemia is amplified.

RESEARCH DESIGN AND METHODS: One-hundred-and-eight adults with T2DM (mean duration 1.8±1.4 years) received 3-weeks of IIT (glargine, lispro). Oral glucose tolerance tests before and after IIT enabled assessment of beta-cell function by Insulin Secretion-Sensitivity Index-2 and insulinogenic index/HOMA-IR. For each level of baseline fasting glycemia from 6.0 to 10.5 mmol/l, we modelled the difference in IIT-induced percentage change in beta-cell function between those at/above the indicated glucose level and those below it.

RESULTS: The relationship between baseline fasting glucose and the differential change in beta-cell function was non-linear. Instead, this relationship was best fit by cubic regression model with inflection (amplification) at fasting glucose 9.3 mmol/l. Moreover, baseline fasting glucose 9.3 mmol/l also identified the inflection point at which non-linear reductions in fasting glucose and 2-hour glucose, respectively, were both amplified.

CONCLUSION: The respective improvements in beta-cell function and glycemia in response to short-term IIT are amplified in those in whom baseline fasting glucose exceeds a defined threshold, consistent with reversal of glucotoxicity.
Family history of diabetes and clinical characteristics in children at diagnosis of Type 1 diabetes – a Swedish population-based study
Authors: Hedlund Emma , Tojjar Jasaman , Lilja Lisa , Elding Larsson Helena , Forsander Gun , Ludvigsson Johnny , Marcus Claude , Norström Fredrik , Persson Martina , Carlsson Annelie
Published: September 2024

Objective: To compare the prevalence of parental diabetes between children with and without type 1 diabetes, and to compare clinical characteristics at diagnosis of type 1 diabetes in children with, versus without, a family history of diabetes. Research Design and Methods: Parental diabetes among children with type 1 diabetes was compared with a general population cohort. Clinical characteristics were compared by family history of diabetes in parents and grandparents of 3,603 children with type 1 diabetes using relative risk and ANOVA. Results: Children with type 1 diabetes more often had parents with type 2 diabetes (RR 1.88, p<0.001) than children without diabetes. Children with type 1 diabetes and a family history of type 2 were more likely to be overweight or obese (p=0.002). Conclusion: A family history of type 2 diabetes and being overweight may contribute to increased risk of type 1 diabetes.
Overproduction of gamma-aminobutyric acid and increased antioxidant capacity by Lactiplantibacillus pentosus TEJ4 through optimization by response surface methodology
Authors: Orantes-Pérez Doryan Osmara , Vázquez-Ovando Alfredo , Coronel-Niño Rito , López-Martínez Gemelli , Ruiz-González Sonia , Mejía-Reyes David
Published: September 2024

Lactic Acid bacteria (LAB) are the main producers of bioactive compounds (peptides, exopolysaccharides, antioxidant compounds, gamma-aminobutyric acid-GABA, etc.). Different strains produce at least one metabolite in high quantities as part of their metabolism, however, there are few reports of LAB with the capacity to produce two or more metabolites simultaneously. Due, the ability of 35 LAB strains previously isolated from dairy products, fermented beverages, and honey to produce gamma-aminobutyric acid (GABA) and the antioxidant capacity was determined. Based on analysis of variance and subsequent comparison of means, the Lactiplantibacillus pentosus strain was selected, and subsequently, using a Draper-Lin small composite design, the conditions of the culture medium (MRS broth) were optimized to achieve the highest production of GABA and increase the antioxidant capacity evaluated by the DPPH assay. The optimal conditions for obtaining 7.99 mg/mL of GABA were 100 mM glutamic acid, a pH of 6, a temperature of 40 °C, and 72 h of fermentation. To obtain the highest antioxidant capacity (6.87 µmol TE/mL), 200 mM glutamic acid and a pH of 4.0 were used. We reported an isolated strain of nondairy product (L. pentosus TEJ4) with the capacity to produce both bioactive, GABA, and antioxidants in a single fermentation process in a non-dairy defined medium, which is a feasible alternative to the normal process of producing bioactive compounds.
Who are the Culprits? Evaluation of Theft and Mutilation of Academic Library Materials: Experience from the Walton Whaley Library
Authors: Ameyaw Samuel , Nana Eleduh Amoah Charles , Frempong-Kore Afua
Published: September 2024

This study assesses the theft and mutilation of library resources at Walton Whaley Library (WWL) at Valley View University, in Ghana. The study adopted a mixed-method approach; thus, copies of questionnaire and interviews were used to gather data for the study.
The quantitative and qualitative data were analyzed with the help of Nvivo version 11 and IBM Statistical Package for the Social Sciences (IBM-SPSS version 21.0). The study found that most of the users were aware of the security policies in the library. The prominent factors influencing theft and mutilation are a weak security system, the absence of closed-circuit television (CCTV) cameras, inadequate staff, the selfish interests of the perpetrators, and a lack of security personnel at the main entrance. To curb this phenomenon, certain security measures, such as the installation of electronic security devices, security personnel at the main entrance, physical body checks on users entering and exiting the Library, as well as staff surveillance are needed. The study recommended an effective and efficient security system, the vigilance of library staff, the acquisition of multiple books in high demand, availability and accessibility of photocopying services. The study suggested harsh punishment for perpetrators who breach library rules.
Breaking Boundaries
Authors: Wang Alison
Published: September 2024

This article explores the evolving role of librarians in small to medium-sized academic libraries, using the Everett I.L. Baker Library at Norwalk Campus, Connecticut State Community College, as a case study. As academic libraries transition from traditional, specialized roles to more versatile staffing models, the importance of cross-training among library staff becomes increasingly apparent. In environments dominated by electronic resources and constrained by limited budgets, libraries must adapt by developing a workforce capable of handling diverse tasks, from cataloging to providing research assistance. This article details the Norwalk campus library's implementation of a cross-training program designed to enhance staff flexibility, professional growth, and service delivery. Through comprehensive training in circulation, reference services, cataloging, and technical support, the library has successfully created a more cohesive and responsive team, better equipped to meet the dynamic needs of its academic community. The findings underscore the critical role of continuous learning, collaboration, and adaptability in modern academic librarianship, positioning cross-training as a key strategy for ensuring the sustainability and relevance of academic libraries in today's rapidly changing educational landscape.