bluuebunny/crossref_metadata_2025 huggingface dataset:
A Phase II Trial of Netupitant/Palonosetron for Prevention of Chemotherapy Induced Nausea/Vomiting in Patients Receiving BEAM Prior to Hematopoietic Cell Transplantation
Authors: Bubalo Joseph S. , Radke Jennifer L. , Bensch Kenneth G. , Chen Andy I. , Misra Shikha , Maziarz Richard T.
Published: November 2022

Objective
The purpose of this study was to investigate the efficacy and safety of NEPA for the prevention of CINV for HCT patients receiving BEAM therapy.
Study Design
This phase II, prospective, intention-to-treat, single-center, single arm study involved 43 adult patients who received NEPA and dexamethasone for prevention of CINV due to BEAM conditioning chemotherapy. An interim analysis, performed after 13 patients, determined utility versus futility and supported continuation to full enrollment. Descriptive statistics were used to report complete response (CR), complete protection (CP), incidence of emesis, and administration of rescue agents. A Kaplan-Meier curve depicted time to first emesis and first rescue medication. Patients self-reported levels of daily nausea descriptively via a CINV Questionnaire.
Results
By study end, 13 of 43 patients achieved a CR with an average of 10.6 emesis free days (SD 0.95) over the 11-day observation period, with no emetic events in any patient during the acute/chemotherapy phase. Nausea was well controlled throughout the acute therapy phase (Days 1–6) and increased during the delayed phase (Day 7–11) with a peak mean level of 2.79/10 at Day 10. Aside from lower grade (≤ 2) headaches, constipation and diarrhea were the most widely reported adverse effects.
Conclusion
The combination of NEPA and dexamethasone is safe and effective for the prevention of CINV in patients receiving BEAM conditioning therapy prior to HCT. The regimen demonstrated greater effectiveness in the acute phase versus the delayed phase, with low levels of nausea throughout the study period and complete emesis prevention during chemotherapy. NCT03097588 registered March 31, 2017.
Genetic parameters analysis of conformation traits and milk production traits in Chinese Holsteins
Authors: Xue Xiaoshu , Ma Yun , Hu Honghong , Ma Yanfen , Han Liyun , Hao Feng , Jiang Yu
Published: November 2022

Background: The objective of this study was to explore the genetic parameters of conformation traits and milk production traits of Chinese Holstein cattles in Northwest China, and to provide a reference for dairy cattle breeding in this region. The phenotypic data of 23 conformation traits and 5 milk production traits of 7,930 Chinese Holsteins from 18 pastures from 2007 to 2020 were collected. With field, identification season, calving season, and appraiser effect as a fixed effect and individual additive genetic effect as a random effect, DMU package and AIREML combined with EM algorithm were used to estimate the genetic parameters of conformation traits and milk production traits.
Results: The estimated heritability of conformation traits ranged from 0.11 (angularity) to 0.37 (heel dept), and the genetic correlation between conformation traits ranged from -0.73 (bone quality and rear leg-rear view) to 0.76 (chest width and loin strength). The estimated values of genetic correlation between conformation traits and milk production traits ranged from -0.31 (pin setting and milk yield) to 0.34 (stature and milk yield), -0.33 (pin setting and 305-d fat) to 0.57 (breast texture and 305-d fat), -0.32 (pin setting and 305-d protein) to 0.38 (udder texture and 305-d protein), and -0.43, respectively (heel dept and somatic cell score) ~ 0.34 (body depth and somatic cell score) and -0.56 (foot angle and 305-d milk yield) ~ 0.32 (body depth and 305-d milk yield). There was a positive genetic correlation between most conformation traits and 305-d fat and 305-d protein, but a weak genetic negative correlation with milk yield.
Conclusions: Strengthening the selection of medium and high heritability of milk production traits and conformation traits, especially the selection of rear udder traits and body shape total score, was beneficial to improve the performance of dairy cows.
Experimental Analyses of Eco-friendly Plasticizer on Taro Starch-based Bioplastic for Injera Packing Application
Authors: Ayalke Bethelhem Hailemichael , Woldemichael Dereje Engida
Published: November 2022

This work aims to characterize the properties of taro starch-based bioplastic reinforced with bicarbonate and modified egg shells as reinforcement, which was manufactured as taro starch film with PVA and glycerol as a plasticizer. Films made of starch have drawbacks, including being mechanically weak, brittle, and having hydrophilic characteristics. This study looked into the bioplastic's XRD, FTIR, thermo mechanical, tensile testing, surface morphology, and moisture absorption in comparison to another bioplastic. According to the results, the film was composed of 4% taro starch, 4% PVA, 2% egg starch, 2% bicarbonate bio filler and plasticizer. The tensile strength of the samples was 92.6 MPa, which was the highest of all the samples. Furthermore, the amount of plasticized and bio fillers added to the taro starch film improved its tensile strength and thermal stability. The maximum water absorption in the films was loaded 45.5% retained. In terms of characterization, spectra of Fourier transform infrared spectroscopy (FTIR) functional groups sampled results of OH, NH, CH aliphatic, C = O, C-O, C = C, S = O, and C-Br in the starch/PVA molecules were improved. Temperatures observed by differential scanning calorimetric (DSC) taro starch/PVA with bio filler for TS1-31 and TS1-32 Tg results from 113–131°C, Tc results from 138–156°C, and Tm results from 186–194°C, respectively, for all samples of BP film containing 4% taro. To the best of our knowledge, no investigation like this has ever been conducted. In general, the production of bio plastics can be substituted with a combination of starches from two separate sources.
Dose pulmonary hemorrhage increase the risk of bronchopulmonary dysplasia in very low birth weight infants?
Authors: Pan Jing-jing , Tong Mei-ling , Jing Wang , Zhou Xiao-yu , cheng rui , Yang Yang
Published: November 2022

Objective: To evaluate the association between pulmonary hemorrhage and bronchopulmonary dysplasia (BPD) in very low birth weight infants (VLBWIs).
Methods: The study participants were all VLBW newborns admitted from January 1, 2019 to December 31, 2021. The finally included subjects were VLBWIs who survived to discharge. This study was divided into pulmonary hemorrhage group (PH group, n=33) and non-pulmonary hemorrhage group (Non-PH group, n=181).
Results: By univariate analysis it was found that premature rupture of membranes, tracheal intubation in the delivery room, duration of mechanical ventilation, course of invasive ventilation (≥3 courses), pulmonary surfactant (>1 dose), medically and surgically treated patent ductus arteriosus, grade III-IV RDS, and early onset sepsis showed significant differences between groups (p<0.05). By univariate analysis, pulmonary hemorrhagedid not increase the risks of BPD and moderate to severe BPD. However, if the interference of invasive ventilation is excluded, pulmonary hemorrhage could increase the incidence of BPD (aOR=3.295, 95%CI1.183-9.179).
Conclusion: Our data suggests that pulmonary hemorrhage is not associated with the development of BPD and moderate to severe BPD in VLBWIs.
Homogeneous Regions of Precipitation Trends Across the Amazon River Basin, Determined From the Global Precipitation Climatology Centre - GPCC
Authors: Filho David Figueiredo Ferreira , Pessoa Francisco Carlos Lira
Published: November 2022

Spatiotemporal patterns of precipitation are influenced by complex interactions between climate and land cover changes, such as deforestation, fires and droughts. The Amazon River Basin has local and global impacts in regard to the hydrological cycle; therefore, it is fundamental to understand how precipitation patterns and intensity are changing. The aim of this study was to analyze precipitation trends and form homogeneous regions of precipitation trends in the Amazon River Basin using data from the meteorological satellite Global Precipitation Climatology Centre (GPCC), applying nonparametric methods (Mann-Kendall, Spearman and Sen's slope) and fuzzy C-means to identify specific regions that are undergoing changes in hydrological patterns. The results show changes in the behavior of rainfall over time and in the intensity of the events. The statistics applied to form clusters resulted in 6 well-divided homogeneous groups, each with unique characteristics. Specifically, the central-southern areas of the basin showed negative precipitation trends (-1.17 mm/year) forming a homogeneous region (RH 1), while in the northern region, there was an increasing trend in precipitation (2.73 mm/year). In general, over the 37 years studied, the wet areas have tended to become wetter and the dry areas drier. Other homogeneous regions had their own results and unique characteristics, which are in agreement with other studies, such as those in Porto Velho, Rondônia, where this area had a diagonal pattern of precipitation decrease.
Radar emitter threat evaluation based on the algorithm involving behavioral characteristics and BiasSVD
Authors: Jundi Wang , Xing Wang , junmei Feng , Yuanrong Tian , You Chen
Published: November 2022

In order to minimize the impact of errors and uncertainties that arise from signals received by reconnaissance equipment and airborne radar on emitter threat evaluation, to reduce such evaluation’s dependence on parameters, and to predict better the extent to which an air-battle target is posing a threat, the paper examined the radar emitter and dynamic characteristics of a target from a behavioral perspective using data-fusion-based emitter threat evaluation. It was followed by a shift from the concrete description of a complicated air-battle situation to an abstract one, and the proposed algorithm’s fault tolerance increased. With that, a threat assessment system built on behavioral characteristics was established. Under that system, we calculated the membership of each sub-behavior indicator’s vague dataset, optimized threat evaluation weights using the dynamic variable weight method, and computed the threat value with an improved radar chart. This was how an emitter threat was swiftly and accurately assessed. As to failures to precisely evaluate the threat of a target due to a lack of needed information for it being beyond the scope of an aircraft warning device or a radar receiver, we, in this paper, employed the collaborative filtering algorithm and predicted the threat degree in the case of non-existence of emitter behavior or existence of a target escaping radar detection by analyzing the situational environment of other fighter aircraft in the same airspace.
Evaluating impact of Nd:YAG laser associated defects on optical quality of hydrophilic and hydrophobic intraocular lenses using visualization of light propagation and USAF test targets.
Authors: Borkenstein Andreas F , Borkenstein Eva-Maria , Omidi Pooria , Langenbucher Achim
Published: November 2022

Introduction:
Neodymium:yttrium aluminum garnet (Nd:YAG) laser capsulotomy is a well-accepted, safe, and effective measure in the treatment of posterior capsule opacification. However, iatrogenic intraocular lens damage (YAG-pit/YAG-shot)) is a relatively common side effect that happens due to inappropriate focusing during the procedure. The purpose of this experimental study is to analyze the impact of YAG-pits on the optical bench to obtain qualitative information.
Methods:
Acrylic, monofocal hydrophilic and hydrophobic intraocular lenses (IOLs) with 6.0mm optic and the with the same power (21D) were studied. First, all measurements were done with unmodified IOLs. Damage was intentionally created, performing YAG-pits (n=5) in the central area of the lens optic (3.0mm) using a photodisruption laser with the same energy level of 1.8mJ. To simulate the cruciate pattern, the 5 defects were created in a cross shape within the 3.0mm optical zone. Afterwards, all laboratory measurements were repeated: These included the United States Air Force (USAF) resolution test chart to study the imaging performance of the IOL, light field measurements to show the course of the rays behind the IOL and the modulation transfer function (MTF) measurements were analysed.
Results:
Evaluating USAF showed that unmodified lenses produced a sharper image. Damaged lenses led to a more blurred image and to the impression of a lower contrast with a kind of halo/glare effect. The light field measurement showed that YAG-pits led to a kind of dispersion and scattering effect, which was higher in hydrophobic IOLs. The MTF showed a deterioration in damaged hydrophilic and hydrophobic IOLs, respectively.
Conclusion:
Our experimental study confirms that YAG-pits can reduce imaging quality of intraocular lenses. These defects behave as a new Huygens source, distribute a spherical wave that additionally illuminate the background of the USAF target. It can be assumed that material properties of the IOL (water content, refractive index) play an important role and affect results. The impact level is strongly dependent on the number, size and position of YAG-pits within the optic. Limitation of the study: only monofocal IOLs have been investigated so far, further tests with various lenses are necessary. In addition, tests to simulate the circular pattern of YAG capsulotomy are necessary.
Weak-value-amplification enhancement of the Magneto-optical Kerr effect in nanoscale layered structures
Authors: Huang Jing-Hui , Lundeen J. S. , Dada Adetunmise C. , Jordan Kyle M. , Wang Guang-Jun , Hu Xiang-Yun
Published: November 2022

The achievement of the larger Magneto-optical Kerr rotations in nanoscale layered structures is extremely important for both theoretical understandings and practical applications. In this paper, we propose a scheme for simultaneously detecting the Kerr rotation and the Kerr ellipticity based on the weak-value amplification (WVA) technique. In the Magneto-optical Kerr effect study for the layered structure, the Kerr rotation and the Kerr ellipticity are obtained by calculating the boundary matrix and the transmission matrix of the layered structure. Then, the Kerr rotation and the Kerr ellipticity can be effectively amplified as the parameters of the pre-selection in the standard weak measurement. In addition, we numerically investigate the dependence of the thickness d of Co in the nanoscale layered structure HfO2 (10~nm)/Co(d nm)/ HfO2 (30 nm)/Al(40 nm)Si films and the Co(d nm)Si films at the measurement range of 5 nm < d < 50 nm. Simulation results confirmed that the Kerr rotation and the Kerr ellipticity can be effectively amplified by choosing the appropriate post-selected state, especially when the nanoscale layered structure shows no advantage for enhancing Kerr signals over the Co(d nm)/Si films without the weak-value-amplification technique. The realization of enhancement of Kerr signals in a nanoscale layered structure may have an important application in the magneto-optic (MO) parameters measurement and the MO properties in a more complex nanoscale structure.
Modulating the Assembly of Egg Yolk Granule-based Delivery Systems using NaCl: Physicochemical Properties and Curcumin Bioactivity
Authors: Li Teng , Su Huanhuan , Zhu Jiaqian , McClements David Julian , Fu Yuying
Published: November 2022

Our previous study demonstrated the potential of yolk granules for the encapsulation and delivery of lipophilic bioactive compounds. In this work, by modulating reassembly of granules using NaCl, curcumin was successfully encapsulated in reassembled granules, resulting in formation of nanoparticles (Gra-Cur NPs). It has been found that curcumin was mainly bound to the granules through hydrophobic interactions. The encapsulated curcumin was in an amorphous state. The Gra-Cur NPs exhibited good dilution, storage, and thermal stabilities. The UV-light stability of curcumin was significantly improved after encapsulation. The encapsulated curcumin had similar or better free radical scavenging activity than curcumin dissolved in organic solvent. The anti-proliferation activity against HT-29 cells of encapsulated curcumin was higher than that of curcumin dissolved in DMSO. The encapsulated curcumin also had better bioavailability, as shown by an Caco-2 cell model. The findings of this study may facilitate the design, fabrication, and application of granule-based delivery systems.
The Effect of the Covid-19 Pandemic on Specialty Choices of Dental Students
Authors: EDEBAL Zehra , DOĞAN Salih
Published: November 2022

We aimed to evaluate the effect of the COVID-19 pandemic on the career plans and self-perception of knowledge levels of undergraduate dental students. In this multicentre cross-sectional study, a multiple-choice survey was taken by students from three different universities in two countries in 2020. Chi-square test or Fisher’s exact test was used to determine statistically significant differences. Of the 755 students that participated in our study, 66% had fear of being at risk for contagion and only 46% claimed to have adequate knowledge about occupational infections and the methods to protect themselves. Utilization of credible publications, guidelines (57% vs. 34%, p < 0.001), and online education (19% vs. 8%, p < 0.001) were significantly higher in students claiming to have adequate knowledge. 11% of the students debated dropping out of dental education because of the COVID-19 pandemic. These students had a markedly elevated rate of fear of being at risk for contagion because of the COVID-19 pandemic (80% vs. 64%, p = 0.011). 76% of the students were aiming for a dental specialty. 18% changed their desired specialty and 22% were in search of a specialty that requires less close contact procedures because of the COVID-19 pandemic. Providing students with sufficient information from trustworthy sources through distance education, as well as psychological support when needed has crucial importance for a successful dental education and career planning.
Predictive ANN modelling of Thermorheological properties of Iron-Oxide yield stress nanofluid
Authors: DHAR SURAJ Narayan , Hassan M.A
Published: November 2022

The intent of the research is to find the dependency of the volume fraction of nanoparticle (φ) and the temperature on the absolute viscosity (µnf) of Fe3O4nanoparticles in Carbopol polymer gel. Rheological and stability analysis of the solution is identified. A total of 48 viscosity values has been calculated from experiments using two different base fluid concentrations and two different nanofluid concentrations at eight different temperatures. The data gathered are used for the training of an ANN (Artificial Neural Network) to observe results in a predefined range of two input criteria. It uses a feed-forward perceptron ANN with a temperature input, a volume concentration input, and a viscosity output. The topology was established by trial and error, and the two-layer model having ten neurons in the hidden layer that used the tansig function produced the best results. Ten training functions were utilized to analyze the best result for nf prediction, and the trainbr algorithm was found to be the best ANN. Due to the trained ANN, the anticipated value of viscosity is obtained from each temperature and volume concentration combination. The best results were witnessed with trainlm algorithm with an MSE value of 5.92e-4 and a R2value of 0.9988 for forecasting of viscosity. Nanoparticle volume concentration increases with viscosity, while temperature increases cause viscosity to decrease. As the temperature rises from 15°C to 50°C, the shear stress value drops with a corresponding shear rate. The shear stress value of the associated shear rate decreases as the nanoparticle concentration rises.
Transcriptome-based mining and expression profiling of low-Nitrogen-responsive transcription factors in yellowhorn (Xanthoceras sorbifolia Bunge)
Authors: Sun Jingliang , Jin Chunyi , Zou Jixiang , Li Xinlin , Wang Mei , Yang Chengchao , Li Linlin , Jin Hua
Published: November 2022

Nitrogen (N) deficiency affects various pathways in plants, while transcription factors (TFs) play crucial roles in regulating metabolic processes. However, there is restricted information about the activation of TFs in trees subjected to low-N stress. We assessed these functions by identifying and predicting TFs in yellowhorn, a high-quality raw material for the production of biodiesel, under low-N stress. We performed comparative transcriptome analysis to study the overall expression of TFs in yellowhorn under different N concentrations. A total of 56 TF families, including 1,873 TF genes, were identified. Among them, 410 (approximately 22%) TFs were detected at significantly higher or lower differential expression levels in both N deficiency treatments than in normal N conditions. We then sorted eight TF families (593 TFs) related to N stress based on previous studies and determined whether they respond to low-N stress. Further phylogenetic and conservative analyses showed that TFs in yellowhorn were clustered according to their phylogenetic affinity, providing a better understanding of their functional diversity. Protein interaction and Gene Ontology (GO) analyses predicted that TFs mainly functioned in hormone conduction, oxidative stress and defense responses. In addition, some TFs involved in salicylic acid signaling, jasmonic acid signaling and antioxidant stress pathways were significantly expressed, implying that these components may help yellowhorn adapt to N deficiency. This study contributes to a better understanding of the complex mechanism of TFs in response to low-N stress in yellowhorn and lays a foundation for exploring yellowhorn TFs genes involved in low-Nitrogen-responsive.
Immunotherapy of multi-drug resistant hematologic malignancies with IL-2-activated intentionally mismatched lymphocytes
Authors: Slavin Shimon
Published: November 2022

Donor lymphocyte infusion using IL-2 activated donor lymphocytes following allogeneic stem cell transplantation (SCT) can sometimes eliminate multi-drug resistant (MDR) cancer cells and result in a cure. We hypothesized that more effective and faster immunotherapy could be accomplished by non-engrafting Intentionally Mismatched IL-2 Activated Killer cells (IMAK) with no prior SCT, avoiding the risks of GVHD due to consistent spontaneous rejection of killer cells after induction of cancer cytotoxicity. IMAK was applied for the compassionate treatment of 33 patients with MDR hematological malignancies following mild immunosuppressive conditioning. IMAK infusion was followed by low-dose subcutaneous IL-2 injections for ≤ 5 days for in vivo activation of donors’ and patients’ lymphocytes. Cumulative experience confirmed major anti-cancer responses following treatment with IMAK including in patients relapsing after myeloablative SCT. Treatment of relatively low tumor burden resulted in cure (> 5 to > 28 years unmaintained disease-free survival). Treatment was reasonably well-tolerated or manageable with no grade IV toxicity. Circulating donor lymphocytes were undetected beyond day + 6, confirming that early spontaneous rejection prevented the risk of GVHD-like toxicity. Immunotherapy potentially resulting in cure could be accomplished in patients with resistant hematologic malignancies when treated with relatively low tumor burden by transient circulation of IMAK. Since MRD can be accomplished in most patients with hematologic malignancies following successful first-line or high-dose chemotherapy, eradication of MRD in otherwise incurable patients could possibly be accomplished by IMAK. Prospective randomized clinical trials are indicated to confirm our working hypothesis.
Effects of biofertilization with plant growth promoting bacteria in micropropagation of Jacaranda mimosifolia
Authors: Salotti Ariel Horacio , Yarte Mauro Enrique , Larraburu Ezequiel Enrique
Published: November 2022

Jacaranda mimosifolia(Bignoniaceae) is an important economic, ecological and ornamental tree native to South America. It is cultured in squares, parks and gardens throughout America, Europe, South Africa and Asia. During plant-microbe interactions,
plant growth promoting bacteria (PGPB) could optimize plant production by mitigating undesirable features which trouble ex vitro transferring. So, the aim of this work was to evaluate the effect of biofertilization with A. brasilense Az39 (as reference strain), Methylobacterium sp. L10 and Stenotrophomonas sp. L20 on micropropagation of Jacaranda mimosifolia. Woody Plant Medium (WPM) was used for seeds germination whereas Murashige and Skoog salts with Gamborg vitamins (MSG) supplemented with 6-benzylaminopurine (BA) were used in multiplication stage and supplemented with indole butyric acid (IBA) were used in rooting stage. All stages were inoculated or not with Az39, L10 or L20. Culture system, bacteria inoculation in each micropropagation stage and their interaction were significant. Methylobacterium sp. L10 and Stenotrophomonas sp. L20 decreased fungal contamination at initial establishment by seeds. In addition, Methylobacterium sp. L10 inoculation increased the multiplication rate by 94% relative to non-inoculated shoots. Stenotrophomonas sp. L20 inoculation in combination with a pulse with 30 μM IBA increased in vitro and ex vitro rooting percentage. In the acclimatization stage, 95% of ex vitro-rooted plants inoculated with Stenotrophomonassp. L20 survived. The strains used at this work could act as biological control agents and could be used for biofertilizers development.
A secondary analysis evaluating retention in care among HIV-positive infants diagnosed at birth using centralized laboratory and point-of-care testing in Pretoria, South Africa
Authors: Christie Michael , Mazanderani Ahmad Haeri , Moyo Faith , Sherman Gayle , du Plessis Nicolette
Published: November 2022

Background:
Birth HIV PCR Point-of-Care (POC) testing can potentially augment the early infant diagnosis (EID) program. Data on the clinical benefits of birth POC testing in South Africa is limited. We compared attrition rates and six-month outcomes of HIV-positive infants diagnosed at birth using POC or laboratory-based testing.
Methods:
From 2018 to 2019, HIV-exposed infants underwent a birth POC test at Kalafong Provincial Tertiary Hospital in Pretoria, South Africa. They were compared with a historical control born between 2014 and 2016 who received only laboratory-based testing. Both groups received similar care. Variables associated with attrition and the impact thereof, after six-months post HIV diagnosis, were compared. Attrition was defined as patients no longer in care at the end of the study period.
Results:
Overall, 52 HIV-positive infants were enrolled (POC group, n=23; control group, n=29).Most mother-infant pair (MIP) attrition occurred in the neonatal period post antiretroviral therapy (ART) initiation (30.4% vs. 20.6%, p=0.24); although not statistically significant, recent maternal ART initiation (<3 months) was associated with higher attrition (1.17, 95% CI 0.22-6.22). More POC MIPs were admitted (19 vs. 14, p=0.02), eight MIPs were admitted for ART initiation. Six-month outcomes demonstrated similar retention rates (65.2% vs. 58.5%, p=0.77).
Conclusion:
Attrition rates of HIV-positive infants post-initiation remain high irrespective of diagnostic method used. Although POC led to earlier engagement with HIV-positive MIPs, this did not translate to improved retention in care. Greater emphasis should be placed on reducing attrition by identifying and remedying any potential antenatal and postnatal risk factors.
Robust tracking and consensus control of a MEMS gyroscope multi-agent systems with H-infinity performance: A transfer function approach
Authors: Nasir Muhammad , Ahmed Zahoor , Aslam Muhammad Muzamil , Du Liping
Published: November 2022

Microelectromechanical system (MEMS) devices face unique issues of control and measurement in contrast to conventional devices due to smaller size, lower manufacturing cost, and less power utilization. A MEMS gyroscope multi-agent system is one example of a MEMS device which have many industrial applications. Despite the significant industrial applications of MEMS gyroscope multi-agent systems such as airbag filling systems, stabilization of image, etc., it faces problems of stability and performance due to the existence of external disturbances, noise, and variations in the parameters. So, designing a consensus controller in the presence of uncertainties and disturbances is a challenging task. The basic purpose of this work is to investigate the issues faced by the MEMS gyroscope multi-agent system and propose a non-linear robust tracking and consensus control technique for the drive axis of the multi-agent system MEMS gyroscope. For this purpose, a controller is designed for the robust tracking and consensus control of MEMS gyroscope multi-agent system by the combination of H∞ consensus control and dynamic surface control approaches. The proposed H∞ consensus controller minimizes the external disturbance effects, makes the drive axis achieve resonance, and a tuning method is derived to tune the output response of the drive axis to the desired level. Further, we simulated a closed-loop system to discuss the controller features. In the last part of the paper, simulation examples are presented to verify the effectiveness of the proposed controller in the presence of uncertainties
Extended least square homotopy method for solving nonlinear systems of fractional partial differential equations
Authors: Thabet Hayman , Kendre Subhash , Peters James
Published: November 2022

Several methods have been developed to solve fractional Partial Differential Equations (PDEs), most of which provide approximate solutions. Exact analytical solutions, however, are important for the proper understanding of the qualitative features of the concerned phenomena and processes. This paper introduces new effective, analytical, and computational extensions of the least square homotopy method (LSHM) for solving nonlinear systems of fractional PDEs. Moreover, the convergence theorem of the solution is also shown. A significant result of the proposed method is that this method yields exact solutions for some models of space-time fractional PDEs. The Graphical representations of solutions are also shown.
What do economic damage estimates tell us about financing loss and damage?
Authors: Tavoni Massimo , Andreoni Pietro
Published: November 2022

Loss and damages is a key topic in international negotiations, but computing the financial claims associated with climate risks is complex. We show that climate-economic impact functions can be used to estimate the size of loss and damages. A fund equalizing climate risks and responsibilities is estimated at 380 USD Billion/yr by 2025, rising over time. We discuss a research agenda that can advance the policy debate.
Designing Molecules to Treat Neurologic and Ophthalmologic Diseases Caused by Sorbitol Excess: Engineering the Agrobacterium Vitis Protein
Authors: Sharma Shonit Nair , Hojati Ashkhan , Yerrabelli Rahul S. , Gnanasambandam Bhargavee , Brozek Joshua
Published: November 2022

This work presents the design of a new protein based on the adenosine triphosphate-binding cassette (ABC) transporter solute binding protein (SBP). The Protein Data Bank in Europe's dictionary of chemical components was utilized to identify sorbitol and D-allitol. Allitol bound to an ABC transporter SBP was identified in the Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB). Wizard Pair Fitting and Sculpting tools in PyMOL were used to replace bound allitol with sorbitol. PackMover Python code was used to induce mutations in the ABC transporter SBP’s binding pocket, and changes in free energy for each protein-sorbitol complex were identified. The results indicate that charged side chains form polar bonds with sorbitol in the binding pocket, thus increasing its stabilization. In theory, the novel protein can be used as a molecular sponge to remove sorbitol from tissue and therefore treat conditions affected by sorbitol dehydrogenase deficiency.
Training Effectiveness (TREF) Provided by Ethiopian Ministry of Revenues Training Centre
Authors: KASSAW MOGES MENGSTU
Published: November 2022

The objective of this study is to investigate and construct a valid and reliable instrument to measure the training effectiveness (TREF) of the training program provided by the Ethiopian Ministry of Revenues Training Center to their tax officers and officials. The research was done through three TREF measures including satisfaction, learning performance, and behavioral change measures. The development of TREF was applied using descriptive statistics average variance explained (AVE), Composite Reliability (CR), and reliability. Data were analyzed using reliability analysis, and structural equation modeling (SEM) using confirmatory factor analysis (CFA) through Stata and Jamovi software. Significantly, the TREF as produced in this research can be used as an instrument to measure the effectiveness of training in the private and public sectors. Subsequently, this effort will support the improvement of quality human resources in the public sector for effective national policy implementation.
Risk Factors and Molecular Epidemiology of Fecal Carriage of Carbapenem Resistant Enterobacteriaceae in Patients with Liver Disease
Authors: Tian Fangbing , Li Yin , Wang Yue , Yu Bing , Song Jianxin , Ning Qin , Jian Cui , Ni Ming
Published: November 2022

Background
Carbapenem resistant Enterobacteriaceae (CRE) colonization is a risk factor for CRE infection. CRE infection results in an increase in mortality in patients with cirrhosis. However, minimal data regarding the prevalence of CRE colonization in patients with liver disease yet without liver transplantation are available. The present study aimed to investigate risk factors and molecular epidemiology characteristics of CRE fecal carriage among patients with liver disease.
Methods
Stool specimens from 574 adult inpatients with liver disease were collected from December 2020 to April 2021. CRE were screened using selective chromogenic agar medium and identified by the Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS). Antimicrobial susceptibility was determined using the broth microdilution method. Carbapenemase genes were characterized by polymerase chain reaction (PCR) and DNA sequencing. Multilocus sequence typing (MLST) was performed for Carbapenem Resistant Klebsiella pneumoniae (CR-KPN) isolates and Carbapenem Resistant Escherichia Coli (CR-ECO) isolates.
Results
The total number of stool specimens (732) were collected from 574 patients with liver disease. 43 non-duplicated CRE strains were isolated from 39 patients with a carriage rate of 6.79% (39/574). The carriage rate increased to 15.18% (17/112) in patients with acute-on-chronic liver failure (ACLF). Multivariate analysis indicated that ACLF (P = 0.022), the history of pulmonary infection within past 3 months (P = 0.001) and the use of third generation cephalosporin/β-lactamases inhibitor within past 3 months (P = 0.000) were independent risk factors of CRE colonization in patients with liver disease. Klebsiella Pnuemoniae (KPN) (51.28%) and Escherichia coli (ECO) (30.77%) were main strains in these patients. All CRE strains showed high resistance to most antibiotics except for polymyxin B and tigecycline. Most (83.72%, 36/43) of the CRE carried carbapenemase genes. blaKPC-2 was the major carbapenemase gene. The molecular epidemiology of KPN were dominated by ST11, while the STs of ECO were scattered.
Conclusions
The present study revealed the prevalence of CRE fecal carriage in patients with liver disease without liver transplantation. Regular CRE screening for hospitalized patients with liver disease should be conducted to limite the spread of CRE strain.
A 258 year-long annual tropical glacial retreat record suggesting warming may not be related to atmospheric CO2 increase
Authors: Milana Juan , Olivares Yanira Rosales
Published: November 2022

Glaciers receive more attention in the climate change debate given their high susceptibility to warming. Long records of direct measurements of glacial processes, however, are limited; as a result, reliable annual mass balance records usually cover less than a century. Tropical examples that are believed to be more sensitive to climate change are among the least studied glaciers worldwide. We present the longest known annual glacial retreat record extending to the present, based on annual moraines formed at the retreating terminus of the Tarija Glacier, in the Bolivian Andes. The availability of high-resolution satellite imagery confirms how these ridges form, substantiating a 258-year glacial retreat history. The annual retreat record is validated by correlation with Lake Titicaca surface level evolution: the highest ablation rate matches the highest lake level (1986-1987). Glacial retreat also matches well with a large Pampean foreland lake level evolution (Mar Chiquita), suggesting this glacier reflects continental-scale climate trends. There is, however, no correlation with CO2 concentration curves. The departure of the glacial retreat chronology, considered to be related to warming, from the CO2 evolution over the last 3 centuries, suggests CO2 does not contribute a primary effect on warming, as most models assume. However, small scale climate shifts may be related to a delayed effect of solar irradiance suggesting that the relation between solar irradiance and its impact on Earth’s surface systems needs to be better understood for a critical examination of the climate change paradigm.
On-line determination of the trace amount of cobalt(II) in real samples by flame atomic absorption spectrometry method after pre-concentration by modified polyvinyl chloride
Authors: Bagherian Ghadamali , Farahani Tahere Zarnoushe , Chamjangali Mansour Arab , Ashrafi Motahare
Published: November 2022

This work reports a simple and sensitive on-line solid-phase extraction system for the pre-concentration and determination of a trace amount of Co(II (ions by flame atomic absorption spectrometry (FAAS). This method is based on the on-line retention of cobalt ions with polyvinyl chloride modified by 3-(2-thiazolylazo)-2,6-diaminopyridine (TADAP) in a mini-column system. The retained Co(II) ions were eluted with 1.0 mol L-1 HCl, and direct aspiration to flame atomic absorption spectrometry (FAAS) for an accurate determination of it. The important experimental parameters such as the solution pH, length of column (adsorbent mass), sample flow rate, solvent eluent, type and concentration of the eluent, and co-existing ion effects were investigated in detail and optimized. Under the optimum conditions, the calibration graph was linear over the concentration range of 2-150 µg L-1 for pre-concentration of 10.0 mL of the sample solution. The interassay precession (n = 6) was in the range of 1.8-5.2% at the concentration levels of 10.0, 50.0, 100.0, and 140.0 µg L-1. The limit of detection and enrichment factor were 1.3 µg L-1 and 40, respectively. The method was applied for determination of trace levels of Co(II) ions in different real samples such as tap water, waste water, vegetable, fruit, and drug with satisfactory results.
Seasonality of SARS-CoV-2 Infections in G20 Countries: Ecological Analysis of Publicly Available Data
Authors:   Orthopedics Surgery, University of Tokyo, Tokyo, Japan, Ueda Munetaka , Yoshida Makoto ,   Faculty of Medicine, Teikyo University, Tokyo, Japan, Yamashita Erika ,   Medical Governance Research Institute, Tokyo, Japan, Bhandari Divya ,   Medical Governance Research Institute, Tokyo, Japan, Endo Michioki ,   Faculty of Medicine, Teikyo University, Tokyo, Japan, Ozaki Akihiko ,   Breast Surgery, Jyoban Hospital of Tokiwa Foundation, Fukushima, Japan
Published: November 2022

Previous laboratory studies of severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) revealed that the stability of the virus in the air or on surfaces is sensitive to seasonally relevant environmental conditions. However, the seasonality of the virus in the real world remains unclear because each country adopted various infection control policies. Therefore, we investigated peak dates with regard to new confirmed cases of coronavirus disease 2019 (COVID-19) and an association of these dates with the timing of the lockdown among G20 countries that have four seasons from 1 June 2020 to 18 February 2021. As a result, countries in both hemispheres experienced seasonal peaks in the number of COVID-19 cases both in the middle of warm and cold seasons. In addition, there were no apparent relationships between the peak date and periods with stringent measures. Our study demonstrated that SARS-CoV-2 causes seasonal outbreaks in the winter and possibly summer and thus, countries might need to consider measures to prepare for resurgence of the virus in the middle of 2021.
Synthesis of boehmite-type GaOOH: A new polymorph of Ga oxyhydroxide and geochemical implications
Authors: Liu Meng , Yin Wei , Jiang Hao-Fan , Wang Yu-Han , Hu Qi-Tao , Zhao Tian-Lei , Yao Qi-Zhi , Fu Sheng-Quan , Zhou Gen-Tao
Published: November 2022

Gallium (Ga) and aluminum (Al) belong to group IIIA elements in the periodic table. They show a coupled geochemical behavior in most natural systems and are considered as “geochemical partners.” However, compared with the principal oxyhydroxides of Al in nature, gibbsite [Al(OH)3], boehmite (γ-AlOOH), and diaspore (α-AlOOH), only the analogs söhngeite [Ga(OH)3] and tsumgallite (α-GaOOH) were reported. In this work, boehmite-type GaOOH (γ-GaOOH), a new polymorph of GaOOH, was synthesized for the first time using boehmite (γ-AlOOH) as a template. The synthesized γ-GaOOH was characterized by a series of techniques, including X-ray diffraction (XRD), high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM), and selected area electron diffraction (SAED). Furthermore, a model based on the boehmite structure was successfully applied to define the γ-GaOOH structure by the Rietveld method. Results from sample characterization and structural refinement support the successful synthesis of boehmite-type GaOOH, and thus it is referred to as γ-GaOOH. The synthesis of γ-GaOOH in the laboratory is valuable to understanding the Ga geochemistry and its enrichment process in Ga-rich boehmite in coal and bauxite.
Penerapan Algoritma Campbell Dudek Smith (CDS) untuk Optimasi Waktu Produksi Pada Penjadwalan Produksi
Authors: Mashuri Chamdan , Mujianto Ahmad Heru , Sucipto Hadi , Arsam Rinaldo Yudianto
Published: November 2022

Research on optimizing production time using the dudek smith campbell algorithm (CDS) in scheduling the production process aims to makepan optimization for machine operations to produce 12 size griddle products, 14 griddle sizes, 16 griddle sizes, 18 griddle sizes and 20 griddle sizes to get the makepan values. optimal. The method applied by the Campbell Dudek and Smith (CDS) algorithm, CDS is a method used in flowshop scheduling developed from Johnson's rule which is able to minimize the makespan of 2 machines arranged in series. The CDS method is very suitable for production characters who apply machine sequences to the production process. CDS produces several iterations that have the value of makespan, from those iterations, the minimum value of makespan is to determine the order of products to be produced. This research resulted in an application that can schedule products to be produced by machines automatically. From the test results with a total production of 12 pieces on each product with 6 repetitions, the minimum value of makespan is 210.12 minutes with a sequence of product works 20 pans, 18 pans, 16 pans, 14 pans, and 12 pans. Accuracy of results Application testing shows 99.99% for the first time and 99.96% for the second time when compared to manual calculations
Analisa Tingkat Usability Berdasarkan Human Computer Interaction Untuk Sistem Pemesanan Tiket Online Kereta Api
Authors: Christanto Henoch Juli , Sediyono Eko
Published: November 2022

The Current technological developments make PT.  KAI (Kereta Api Indonesia) as a business entity that regulates and provides rail transportation services has been transformed into providing online ticket reservation services, one of which is through the KAI Access application.  But it needs to be realized that the marketplace trend has also penetrated travel deals that also provide train ticket reservations, one of which is Traveloka. This interesting phenomenon is the basis for conducting research to see whether the application owned by PT KAI has been able to compete with other applications that also provide online train ticket sales services. By being able to compete, PT KAI can show credibility in providing online ticket transactions. Both applications are tested using the Usability indicators from HCI: Learnability, Efficiency, Memorability, Errors, and Satisfaction.  This study resulted in a comparison of the two applications by each HCI indicator. The discussion on each indicator it can be seen the classification of the level of usefulness from KAI Access and Traveloka
Analisis Penentuan Penginapan dengan Metode AHP dan Promethee
Authors: Muntiari Novita Ranti , Sunardi Sunardi , Fadlil Abdul
Published: November 2022

Traveling to a place with a period of days requires a place to stay. The problem is determining accommodation according to the wishes of different visitors, such as prices according to the type of lodging, complete facilities or not at the inn, and the distance to other places from the inn. There are too many lodging options that make it difficult for visitors to determine the best alternative. This research focuses on lodging in the Malioboro area of Yogyakarta by using the criteria of distance, price, class of accommodation, room facilities, and supporting facilities. AHP method is used to determine the weight of each criterion, then the weight of each criterion is calculated using Promethee with the usual or general criteria preference type, to produce a net flow value. Combination of two methods is better because the AHP method is more suitable to be used to find the weight of each criterion and Promethee by using a preference index as needed by producing suitable alternatives. The result of AHP and Promethee calculations obtained with the PP3 alternativewith a net flow value of 0.2 to be the first rank and it can be stated that the existing criteria are very suitable for what visitors want.
Penerapan Soft System Methodology dalam Ekstraksi Pengetahuan Tentang Akreditasi Universitas XYZ
Authors: Karay Jeni , Manongga Danny , Purnomo Hindriyanto Dwi
Published: November 2022

As a university, accreditation is a benchmark and recognition of quality standards and definitions of an educational institution (higher education) by parties outside an independent institution. Accreditation is also interpreted as an effort by the government to standardize and guarantee the quality of higher education alumni in order to ensure that quality among universities is not too varied and according to work needs. Management of Higher Education needs to improve quality and be an input for stakeholders who continue to improve the university. Using Soft System Methodology, researchers map and conceptualize models and plans to help XYZ University develop its accreditation values. In this case the Faculty of Science and Technology at XYZ University. From this research it was found that the XYZ University's Faculty of Science and Technology can provide alternative funding and development from all parties and grants as well as cooperation in outside universities that will help this faculty to add facilities, improve the quality of supervisors by using technology at the University's Faculty of Science and Technology XYZ. Recommendations given by researchers are faculties can make a web-based DSS (Decision Support System) accessed by intranet to help download traces of faculty development and can be used as a basis for decision making.