bluuebunny/crossref_metadata_2025 huggingface dataset:
Effective and safe control of glycemia with insulin Apidra - the recipe for success of type 2 diabetes prophylaxis
Authors: Biryukova Elena Valer'evna
Published: November 2013

Current possibilities for the use of ultra-short acting insulin analogs are discussed. The importance of control of postprandial hyperglycemia is emphasized.Pharmacological properties of insulin glulisine are described with special reference to its advantage over human ultra-short acting insulin.An important characteristic of glulisine is the possibility of its efficacious use for the treatment of obese patients. The results of GINGER and CHOinternational studies suggest high efficacy and safety of glulisine used for intensive insulin therapy according to both flexible and fixed regimens.
Alpha-lipoic acid in non-proliferative diabetic retinopathy treatment by Demydova T.Yu., Trachtenberg Yu.A.: article critique
Authors: Lipatov Dmitriy Valentinovich , Galstyan Gagik Radikovich , Smirnova Olga Mikhailovna
Published: November 2013

This article addresses modern approach to diabetic retinopathy management. Administration of an agent, not included in the list of evidence basedmethods, such as thioctic acid, is not considered to be an appropriate practice.
Characteristics of metabolic syndrome in women
Authors: Solov'eva Alexandra Viktorovna , Dubinina Inessa Ivanovna
Published: November 2013

Aims. To evaluate combination and manifestation sequence of metabolic syndrome (MS) components, as well as cardiovascular riskfactors in women. Materials and methods. We examined 100 female subjects with MS. We assessed anthropometric parameters, glycemic control andlipid metabolism. We also conducted cardiac ultrasound in all participants. Results. 44% of patients developed abdominal obesity after pregnancy, 48% - in perimenopausal period and in 8% of studied casesobesity manifested in combination with arterial hypertension 10 years before menopause (at the average). Family history of type 2diabetes mellitus and obesity, elevation of LDL and TG characterized post pregnancy abdominal obesity. Postmenopausal obesity wasassociated with significantly lower levels of HDL. HDL concentration was also lower in cases of histerectomia and early age of surgicalmenopause. Conclusion. Manifestation of MS in females is associated with periods of hormonal imbalance. Cardiovascular risk positively correlateswith number of pregnancies, duration of abdominal obesity experience, and negatively - with HDL level and age of surgical menopause.Complete form of MS (with all 6 components present) is found more frequently in women with postmenopausal manifestation.
Coagulation factors II,V and methylene tetrahydrofolate reductase gene polymorphism in patients with diabetic nephropathy: prevalence, clinical and prognostic implications
Authors: Sibireva Olga Filippovna , Khitrinskaya Ekaterina Yur'evna , Kalyuzhin Vadim Vital'evich , Sazonov Aleksey Eduardovich , Ivanchuk Igor Ivanovich , Grankina Viktoriya Yur'evna
Published: November 2013

Aim. To study prevalence, clinical and prognostic significance of prothrombotic genotypes pre-dominant in inborn thrombophilia in patients with diabeticnephropathy (DN). Materials and methods. A total of 90 patients with DN were examined; 54 and 36 cases suffered DM1 and DM2 respectively. Control group comprised100 healthy subjects. PCR was used to iden-tify single nucleotide substitution (C677T) in the methylene tetrahydrofolate reductase gene (MTHFR),point mutation in coagulation factor V gene (FV), and G202210A mutation in factor II gene (FII). Results. The probability of DN in patients with DM1 increases in the presence of Leiden mutation and in DM2 patients in the presence of single nucleotidesubstitu-tion (C677T) in MTHFR gene and G202210A mutation in the 3-untranslated region of FII. Conclusion. The prevalence of the above mutations associated with blood coagulation potential in DN patients is higher than in healthy subjects.Key words: diabetes mellitus, diabetic nephropathy, gene polymorphism, methylenetetrahydrofolate reductase
Circulating precursors of endothelial cells in patients with CHD and disturbed carbohydrate metabolism
Authors: Ruda Maria Mikhailovna , Aref'eva Tatiana Igorevna , Sokolova Angelina Valer'evna , Shestakova Marina Vladimirovna , Karpov Yury Alexandrovich , Parfenova Elena Viktorovna
Published: November 2013

Aim. Circulating precursors of endothelial cells (PEC) play an important role in regeneration of damaged vascular endothelium and myocardium and neovascularization of ischemic tissues. The aim of this work was to study effect of disturbed carbohydrate metabolism (DCM) on the number of PEC in patients with different forms of CHD. Materials and methods. The number of PEC was determined by flow cytofluometry, insulin and C-peptide levels by IFA in 78 patients aged 40-69 (mean 55.5?0.9) years. Control groups comprised 17 subjects without CHD and DCM, 33 patients were allocated to the stable angina (SA) group (48% with DCM), 28 suffered acute coronary syndrome without segment ST elevation (ACS-ST) (39% had DCM). Results. The number of PEC was reduced in all CHD patients, by 23% in the SA group (p
Lipid composition and Na+,K+-ATPase activity in erythrocyte membranes of patients with type 2 diabetes mellitusand dyslipoproteinemia
Authors: Kravets Elena Borisovna , Stepovaya Elena Alekseevna , Koshchevets Tatiana Yur'evna , Medvedeva Olesya Dmitrievna , Yakovleva Natalya Mikhailovna , Yadmaa Oyuunchimeg , Ananina Elena Alexandrovna
Published: November 2013

Aim. To study lipid composition and Na+,K+-Na+,K+-ATPase activity in erythrocyte membranes of patients with type 2 diabetes mellitus and dyslipoproteinemia. Materials and methods. The study included 40 patients (22 men and 18 women) aged 40-65 years with DM2. Results. The patients had abnormal lipid composition and impaired Na+,K+-Na+,K+-ATPase activity in erythrocyte membranes. The magnitude of thesechanges depended on the duration of pathology, severity of diabetic dyslipoproteinemia, and quality of compensation of carbohydrate metabolism. Conclusion. Aim. Investigation of lipid dysorganization in erythrocyte membranes in patients with type 2 diabetes mellitus yields data for the developmentof therapeutic modalities to correct dyslipoproteinemia.
Incidence and graveness of helicobacter infection in patients with type 2 diabetes mellitus
Authors: Mkrtumyan Ashot Musaelovich , Kazyulin Aleksey Nikolaevich , Bairova Kermen Ivanovna
Published: November 2013

Aim. To evaluate the frequency of H.pylori infection and efficiency of its eradication in patients with type 2 diabetes mellitus. Materials and methods. The study included 40 patients with DM2 and 38 diabetics with chronic gastritis (CG). H.pylori was detected by urease assayusing 13C-urea. The degree of stomach bacterial contamination was assessed by a semiquantitative histological method. Control groups comprisedpatients with gastric ulcer and CG having undisturbed carbohydrate metabolism. Results. The frequency of H.pylori infection was virtually identical in patients with and without DM2 regardless of gastric problems. However, comparativeanalysis revealed significant correlation between the graveness of infection and duration of DM2 (r=0.84; p
Myocardial revascularization in diabetic patients presenting with critical limbischemia
Authors: Dedov Ivan Ivanovich , Kalashnikov Victor Yur'evich , Melkozerov Konstantin Vladimirovich
Published: November 2013

The frequency of diabetic complications remains high despite the development of improved therapeutic modalities. Macroangiopathy continues to bethe predominant complication while coronary heart disease is the main cause of mortality.This paper considers clinical features of diabetic patientswith coronary heart disease and critical limb ischemia; various aspects of optimal drug therapy, preoperative examination and diagnostics precedingvascular non-cardiac surgery; preoperative risk assessment; indications for coronary angiography and myocardial revascularization. The authors emphasizethe importance of development of algorithms for the treatment of patients with diabetes, critical limb ischemia, and coronary heart disease.
Barriers for efficacious hypoglycemic therapy in clinical practice (results of the Dialogue study)
Authors: Sapozhnikova Irina Evgen'evna , Anufrieva Elena Nikolaevna , Tarlovskaya Ekaterina Iosifovna , Sobolev Alexander Anatol'evich
Published: November 2013

Aim. To analyse factors hampering the achievement of compensation of carbohydrate metabolism in patients with type 2 diabetes mellitus treated for3 months with diabeton MB at a daily dose of 90-120 mg under real practical conditions. Materials and methods. This open study included 70 patients with type 2 diabetes mellitus given gliclazide MB-based hypoglycemic therapy(90-120 mg/day); their HbA1c level was measured before and 3 months after the onset of therapy. Results. The treatment resulted in a significant decrease of the HbA1c level especially pronounced in patients capable of following the rational therapeuticstrategy. At the closing visit, each patient was prescribed a pathogenetically sound regime of combined hypoglycemic therapy. Conclusion. Poor efficacy of hypoglycemic treatment in real clinical practice is attributable to frequent prescription of monotherapy, untimely onsetof insulin administration, its correction and intensification to meet changing requirements
Chronic wounds and diabetes mellitus: modern concept and prospects for conservative treatment
Authors: Tokmakova Alla Yur'evna , Doronina Lyudmila Petrovna , Strakhova Galina Yur'evna
Published: November 2013

Current trends in conservative therapy of chronic wounds associated with diabetes mellitus are discussed along with results of original studies aimedto assess efficacy of different methods for unloading the affected leg in patients with the neuropathic form of diabetic foot syndrome and diabeticnephropathy. Effects of collagen-containing dressings on the wound-related factors (matrix metalloproteinases 2 and 9, collagenolytic activity) andwound epithelization rate are described.
Diabetic osteoarthropathy: modern methods of therapy
Authors: Ul'yanova Irina N. , Tokmakova Alla Y. , Yaroslavtseva Марианна V. , Ilyin Alexander V. , Galstyan Gagik R.
Published: November 2013

This paper is focused on the main aspects of pathogenesis of diabetic osteoarthropathy (DOAP) underlain by motor and sensory neuropathies, injuries(including microfractures and joint disintegration), and inflammation accompanied by enhanced cytokine expression. The role of osteopenia andbone resorption-formation decoupling at different stages of DOAP is discussed. Modern methods of DOAP treatment are considered with special referenceto immobilization, drug therapy, surgical and orthopedic care
Association of HLA-DQ trans-heterodimers with prevalence of type 1 diabetes mellitus in Buryat ethnic group
Authors: Ivanova Olga Nikolaevna , Prokof'ev Sergey Alexandrovich , Bardymova Tatiana Prokop'evna
Published: November 2013

Aims. Search for the most pronounced HLA II markers of type 1 diabetes mellitus (T1DM) in Buryat ethnic group and analysis ofHLA-DQ trans-heterodimers. Materials and methods. Case control design was applied for assessment of 74 patients with T1DM and 61 healthy individuals. Alleleidentification was performed with multi-primer allele-specific PCR technique. Association of genetic markers with pathology wasevaluated according to odds ratio (OR) index. All calculations were performed with StatSoft and STATISTICA 6 software applications. Results. We show that regarding race-specific highly diabetogenic HLA class II haplotypes Buryat ethnic group holds intermediateposition between Mongoloids and Caucasians and none of those haplotypes are associated with T1DM. We revealed a statisticallysignificant association of T1DM with DQA1*0301+DQB1*0201+ phenotype represented by trans-coding alleles in 77% of cases. Onpopulation level DQA1*0301+DQB1*0302+ or *0201+ phenotype is found to be the most sensitive marker. It was registered in 43%of patients with T1DM against 11.5% of controls (OR 5.9; рс=0.0094). DQA1*0301+/DQВ1*0201 and DQВ1*0302 phenotype is themost specific marker, registered in 16% of patients, but not found in controls (OR 11.8; рс=0.047).Conclusions. HLA-mediated risk for development of T1DM in Buryat ethnic group is determined by HLA-DQ trans-heterodimers.
Antihyperglycemic therapy in patients with type 2 diabetes mellitus and ischaemic heart disease: management during acute period of myocardial infarction and interventional procedures
Authors: Smirnova Olga Mikhailovna , Kononenko Irina Vladimirovna
Published: November 2013

Current paper presents data from international multicenter studies performed with participation of patients with type 2 diabetes mellitus(T2DM) and ischaemic heart disease. We analyze results regarding advisability of different glycemic targets, prescription safetyof various classes of antihyperglycemic agents in patients with inschaemic heart disease, acute coronary syndrome and chronic heartfailure, as well as therapeutic approach to glycemic control in acute myocardial infarction and cardiologic interventional procedures.
Vacuum therapy for chronic wounds
Authors: Zaytseva Ekaterina Leonidovna , Tokmakova Alla Yur'evna
Published: November 2013

Chronic wound in patients with diabetes mellitus (DM) is one of the most urgent problems of modern diabetology and surgery. Numberof patients suffering from different types of chronic wounds follows increase in DM incidence. Vacuum therapy is a novel perspectivemethod of topical treatment for non-healing chronic wounds of various etiology. Current review addresses experimental and clinicalevidence for this method.
Pedographic and clinical assessment of total contact cast immobilization in diabetic foot syndrome
Authors: Gorokhov Sergey Valentinovich , Udovichenko Oleg Viktorovich , Ul'yanova Irina Nikolaevna , Berseneva Evgenia Alexandrovna , Galstyan Gagik Radikovich
Published: November 2013

Aim. To estimate offloading efficiency of total contact cast (TCC) and determine factors, affecting trophic ulcer response to treatment with TCC, as well as ways of their compensation. Methods. 30 patients, receiving an outpatient treatment with TCC for diabetic foot syndrome, underwent routine clinical examination, pedography and walking activity monitoring. We assessed degree of pressure reduction on the planta and the lesion area in particular, in its correlation with treatment outcome. Results. According to pedography data, TCC reduced peak pressure (maximum for all plantar zones) for 20% (from -70% to 84%) and pressure in the lesion area for 55% (-100%; +359%). Similar change was observed for "pressure-time" integral. Percentage of patients with peak pressure in ulceration area
Inсretin-based therapy in patients with type 2 diabetes and chronic kidney disease
Authors: Shamkhalova Minara Shamkhalovna , Shestakova Marina Vladimirovna
Published: November 2013

The program of renoprotection in patients with diabetes mellitus (DM) is based on a conceptual model of development and progressionof diabetic kidney disease, which is the result of combined impact of genetically modulated metabolic and hemodynamic factors. Compensationof carbohydrate metabolism, which is crucial at the clinical debut of nephropathy, becomes problematic at the late stages ofchronic kidney disease (CKD). ADA (American Diabetes Association) and EASD (European Association for the Study of Diabetes)recommendations formalized in a consensus on the treatment of patients with type 2 diabetes (T2D) should only be extrapolated topatients with CKD with great prudence. Incretin-based drugs gain reputation as promising and perspective therapy for metabolic controlin patients with type 2 DM and CKD. There is an obvious need for large-scale, long-term studies involving patients with various severityof renal disease and related complications to assess the potential of this new diabetes therapy trend.
Analysis of typical approaches to outpatient management of type 2 diabetes mellitus
Authors: Sapozhnikova Irina Evgen'evna , Tarlovskaya Ekaterina Iosifovna , Avksent'eva Maria Vladimirovna , Sanatova Anastasia Vital'evna
Published: November 2013

Aim. To analyze typical outpatient management approaches to type 2 diabetes mellitus (T2DM).Materials and Methods. We analyzed 211 files from 7 outpatient clinics, containing case records of patients, regularly examined during2009. VEN, ABC- and frequency analyses were conducted. Results. Prescription percentage for medications with proved prognosis improvement did not substantially differ from recommendedlevel. Main direct expenditures were related to antihyperglycemic, antihypertensive and hypolipidemic agents (class V). Inexpensivemedications without proven efficiency (class N) were prescribed more frequently than those with capacity to improve quality of life(class E). Testing for HbA1c level was found to be of inadequate frequency and thus complicated assessment of antihyperglycemic treatmentefficacy. Number of patients with improvement in arterial hypertension showed an increase, but treatment goals were not achievedin 2/3 of patients (according to office measurement). Prescription frequency of statins, though growing in the course of year, remainedinsufficient; rare testing for LDL complicated assessment of hypolipidemic treatment adequacy. Conclusion. Structure of pharmacological treatment is fairly adequate, but goals of multifactor therapy are not achieved in a significantpercentage of patients, which may be explained by peculiarities of diabetes pathogenesis, prescription of inadequate treatment regimensand doses and insufficient dynamic control.
The role of CD40 receptor-ligand system in the development of diabetes mellitus and its complications
Authors: Bondar' Irina Arkad'evna , Klimontov Vadim Valer'evich
Published: November 2013

The CD40 receptor-CD40 ligand system, along with other signal molecules, plays an important role in the development of immune and inflammatoryreactions. CD40R and CD40L are expressed in lymphocytes, monocytes, platelets, endothelial and smooth muscle cells, pancreatic beta-cells, adipocytes,and other cells. The CD40-CD40L system participates in the formation of immune and inflammatory reactions in the cardiovascular system,platelet production and development of autoimmune diseases. Signals mediated through CD40 receptors are involved in the autoimmune process intype 1 diabetes, inflammation of adipose tissue in DM2, development of atherosclerosis and diabetic nephropathy. Therefore, the CD40-CD40Lsystem can be regarded as a universal pathogenetic factor responsible for immune and inflammatory processes, hyperglycemia, and vascular complications.Measurement of CD40 expression in lymphocytes, monocytes, and adipocytes and sCD40L in blood and urine can be used to diagnose andforetell immune and inflammatory processes associated with diabetes mellitus. HMG-CoA reductase inhibitors (statins) and disaggregants (aspirin,clopidogrel) inhibit activity of the CD40-CD40L system. Further studies of possibilities of pharmacological correction of this system may provide abasis for the development of new therapeutic modalities for the management of diabetes and its complications.
Pharmacoeconomic analysis of conservative strategy for the treatment of patients with diabetic foot syndrome in Moscow
Authors: Kalashnikova Marina Fedorovna , Maksimova Nadezhda Viktorovna , Dedov Ivan Ivanovich
Published: November 2013

Aim. To perform cost-effectiveness analysis of prescription of pharmaceutical products and dressing materials and their consumption volume for inandout-patient treatment of diabetic foot syndrome (DFS). To analyse efficacy of the treatment in terms of modern therapeutic standards. Materials and methods. This retrospective study is based on the medical documentation of 139 DM1 and DM2 patients with DFS from differentmedical facilities of Moscow (2007). 72 patients were given general out-patient care by surgeons of city polyclinics, 50 ones received specialized aidin the regional Diabetic Foot Cabinet. 67 patients were hospitalized: 20 for general care in the department of purulent surgery of a military hospital,27 for specialized care in the department of purulent surgery of a city hospital, 20 for high-technology care in the endocrinological clinic of the FirstMoscow State Medical University. Results. Therapeutic strategy for DFS patients used in the regional Diabetic Foot Cabinet met the current therapeutic standards. General out-patientcare by surgeons of city polyclinics was at variance with the algorithms adopted in this country. Pharmacoeconomic analysis of the spectrum of pharmaceuticalproducts used for in- and out-patient treatment of DFS patients revealed frequent and ungrounded application of drugs whose woundhealing effect remains to be confirmed (pentoxifylline, thioctoic and alpha-lipoic acids). Conclusion. Additional training courses for surgeons of Moscow polyclinics are needed to improve the quality of medical aid to DFS patients. Suchpatients must be referred to regional Diabetic Foot Cabinets. Pentoxifylline, thioctoic and alpha-lipoic acids need to be substituted by pharmaceuticalswith validated therapeutic efficacy.
Mauriac syndrome in adult with type 1 diabetes mellitus
Authors: Molitvoslovova Natalya Alexandrovna , Tokmakova Alla Yur'evna
Published: November 2013

We describe the case of Mauriac syndrome in young adult with prolonged poorly controlled type 1 diabetes mellitus.
Genetics of monegenic forms of diabetes mellitus
Authors: Kuraeva Tamara Leonidovna , Zil'berman Lyubov' Iosifovna , Titovich Elena Vital'evna , Peterkova Valentina Alexandrovna
Published: November 2013

It is universally recognized that autoimmune type 1 diabetes mellitus (DM) is not the only form of this disease in children. Increasingly more children andadolescents present with DM2, MODY, and rarer syndromal forms of DM. The actual prevalence of DM other than DM1 in children and adolescentsis unknown but may be estimated at 10%. Despite rare occurrence of genetic syndromes, they collectively account for almost 5% of DM cases amongchildren. The rapid upgrowth of molecular biology opens up a wide range of possibilities for designating various symptom complexes as nosologically selfconsistentforms. New genetic syndromes associated with DM are annually described. It is important both to adequately identify and treat manifestationsand complications of these syndromes in children and to provide relevant medico-genetic counseling and recommendations to the parents.Key words: non-immune diabetes mellitus, MODY, Wolfram syndrome, neonatal, syndromal forms
Insulin resistance in pathogenesis of type 2 diabetes mellitus
Authors: Mayorov Alexander Yur'evich
Published: November 2013

This review focuses on the mechanisms of impaired sensitivity to insulin associated withevolution of carbohydrate metabolism disorders from enhanced fasting glycemia (EFG) to impaired glucose tolerance (IGT) and type 2 diabetes.Disturbances of glucose utilization at the receptor and post-receptor levels are considered along with the role of glucose and lipotoxicity. Original dataon insulin resistance (IR) in patients with disorders of carbohydrate metabolism are presented. Insulin sensitivity in DM2, EFG and IGT is shownto be 50, 25 and 15% lower respectively than in normal subjects. M-index positively correlates with BMI and quality of metabolic control (HbA1cand triglyceride levels). The differences in clinical and biochemical characteristics of DM2 patients are analysed depending on the degree of IR.Adiponectin and resistin levels in DM2 are shown to be lower than in healthy subjects while TNF-a and proinsulin levels increase. Therapy withmetformin, pyoglitazone, and insulin improves insulin sensitivity even in patients with early disturbances of carbohydrate metabolism. It is concludedthat intensive hypoglycemic therapy should be initiated before marked deterioration of insulin sensitivity developed.
Education of diabetic patients: synthesis of evidence-based medicine and psychological approach
Authors: Mayorov Alexander Yur'evich , Surkova Elena Viktorovna , Motovilin Oleg Gennad'evich , Mel'nikova Olga Georgievna , Shishkova Yulia Andreevna
Published: November 2013

Education of diabetic patients is not only an applied but also a research branch of diabetology. The efficacy of this therapeutic modality must be assessedin accordance with the principles of evidence-based medicine. At the same time, it extends beyond the framework of standard medical actionsand implies the necessity of taking into account the psychosocial context. The main stages of the development of diabetes education at the EndocrinologicalResearch Centre are reviewed including evaluation of the efficacy of structured programs, cooperation with international institutions,and development of new methods. Psychological characteristics of diabetic patients are discussed with reference to taking them into account for thepurpose of education.
Arterial diseases of lower extremities in diabetic patients: current state and prospects of therapy
Authors: Galstyan Gagik Radikovich , Tokmakova Alla Yur'evna , Bondarenko Olga Nikolaevna , Sitkin Ivan Ivanovich , Pryakhina Kira Yur'evna , Mitish Valeriy Afanas'evich , Doronina Lyubov' Petrovna
Published: November 2013

Peripheral artery diseases (PAD) are most serious diabetic complications responsible for the high risk of amputation of lower extremities. The occurrenceof PAD in diabetic patients is much higher than in subjects with undisturbed carbohydrate metabolism. PAD in diabetic patients is frequentlyan asymptomatic condition affecting distal portions of arterial segments and associated with pronounced mediacalcinosis. Standard diagnostic proceduresfor the screening of arterial lesions must be supplemented by non-invasive visualization and measurement of transcutaneous oxygen tensionin patients at risk of PAD and persisting foot ulcers. Of special importance is early diagnosis of critical limb ischemia and prevention of foot lesions.Combined treatment of diabetic foot syndrome in patients with critical limb ischemia includes normalization of foot circulation, surgical interventionand conservative therapy of the wound, monitoring concomitant micro- and macrovascular diabetic complications?
Upgrading Novopen insulin injection systems - 25 years experience
Authors: Galstyan Gagik Radikovich , Galstyan Gagik Radikovich
Published: November 2013

The article deals with the estimate of efficiency and safety evaluation of Novopen insulin injection systems
Neonatal'nyy skrining adrenogenital'nogo sindroma: nachalo puti
Authors: Semicheva T V
Published: November 2013

Abstract
Planning of pregnancy in women with diabetes
Authors: Grigoryan O R , Sheremetyeva E V , Andreeva E N , Dedov I I
Published: November 2013

Pregnancy is a complex metabolic state, which includes dramatic changes in hormone secretion, amid growing demand for energy-rich compounds necessary for growth and development of the fetus. Women with diagnosed diabetes is always a greater risk of obstetric complications, which can be prevented by knowing the risk factors for diabetes, the criteria for early diagnosis, an algorithm of pregnancy, careful management of the postpartum period.
I.I. Dedov. To the 70 anniversary from the date of a birth
Authors: - -
Published: November 2013

Редакция журнала «Вестник репродуктивного здоровья» сердечно поздравляет своего главного редактора, Заслуженного деятеля науки РФ, действительного члена Российской академии наук и Российской академии медицинских наук, директора Эндокринологического научного центра МЗ РФ, главного эндокринолога Минздрава РФ, доктора медицинских наук, профессора Ивана Ивановича Дедова с 70-летием!Мы гордимся тем, что имеем уникальную возможность работать под руководством классика отечественной и мировой эндокринологии. И.И. Дедов является автором целого ряда фундаментальных и прикладных работ практически по всем ключевым направлениям в эндокринологии, известных в стране и за рубежом.Им впервые проведено генотипирование различных этнических групп больных сахарным диабетом, уникальные результаты которого вошли в Международный реестр генетических исследований. И.И. Дедовым разработаны методы медико-генетического прогнозирования индивидуального риска развития диабета в «ядерных» семьях больных диабетом; определены критерии формирования групп повышенного риска; разработаны и внедрены в широкую клиническую практику новые методы диагностики и патогенетического лечения таких сосудистых осложнений, как ишемическая болезнь сердца, синдром диабетической стопы, ретинопатия и нефропатия; создан Государственный регистр больных сахарным диабетом Российской Федерации. По инициативе и при непосредственном участии И.И. Дедоваразработана и реализуется Федеральная целевая программа «Сахарный диабет». В рамках этой программы заново создана диабетологическая служба России, кардинально изменившая ситуацию в стране.И.И. Дедову принадлежит приоритет в разработке алгоритмов ранней диагностики, новейших методов и средств комплексной терапии болезней гипоталамогипофизарной системы, включая опухоли гипофиза; изучении принципов организации и функционирования нейроэндокринной системы в онтогенезе человека, функциональной системы, регулирующей рост и половые функции у мужчин и женщин, включая репродуктивную систему; радиационных и других аспектов эндокринологии.И.И. Дедов является автором работ по изучению нейроэндокринной системы в онтои филогенезе у представителей различных видов животных и человека; им изучена закономерность становления нейроэндокринной системы (системогенез), гетерохронность закладки отдельных звеньев и принципы консолидации последних в функциональную суперсистему.
Reproductive system of women with acromegaly
Authors: Pronin A V , Kirjushchenkov A P , Melnichenko G A , Hohlova I D , Fedorova E V , Pronin V S , Gitel E P
Published: November 2013

192 patients with acromegaly were examined. Their reproductive disorders were found to be a result of the suppressed synthesis of gonadotropin hormones due to the tumor compression of the adenohypophysis, due to blocking effect of hyperprolactinemia on the gonadotropic function or as a result of the direct impact of insulin-like growth factor-I stimulating hyperplastic processes in target organs, such as ovaries, the glandular epithelium of the breast and myometrium. The structure of reproductive disorders in patients with acromegaly includes menstrual disturbances, infertility, early menopause and hyperplastic processes. Close management of the reproductive system, early detection of neoplasia and correction of the existing disorders are highly required during therapy for acromegaly.
Historical stages of development of methods of the assisted reproductive technologies based on fertilisation in vitro
Authors: Vityazeva I I , Barmina I I , Melnichenko G A
Published: November 2013

This article is devoted, in the first place, to the history of in vitro fertilization method (IVF). The main phase of initiation and further perfection of IVF are elucidated. Correlations of the development knowledge and skills in obstetrics and gynecology, endocrinology, pharmacology are revealed. In a chronological order the main achievements of such reproduction medicine sections as embryology with cryopreservation and PGD analysis, functional diagnostics with ultrasonography are recited. Further practical and scientific perspectives of the artificial reproductive technology's method are determined. Special attention attends to the IVF history in Russia and ART problem's condition at present.
How Graphic Visual Health Warnings Affect Young Smokers’ Thoughts of Quitting
Authors: Andrews J. Craig , Netemeyer Richard G. , Kees Jeremy , Burton Scot
Published: November 2013

Two-thirds of adolescent and young adult smokers become lifetime smokers, and one-half of those lifetime smokers will die from this habit. The authors examine alternative persuasive pathways to thoughts of quitting taken by adolescent and young adult smokers when exposed to graphic visual health warnings on cigarette packages. For adolescent smokers, the authors find that graphic warnings and smoking frequency affect fear, and fear influences negative health beliefs about smoking, ultimately increasing thoughts of quitting. They also find that the graphic warning and a graphic warning × smoking frequency interaction have incremental effects on quit thoughts beyond the effects of fear and negative health beliefs. Using a longitudinal design with a sample of young adult smokers, the authors find support for many of the adolescent smoker findings, particularly the incremental effects of graphicness and its interaction with smoking frequency. These similar results from diverse samples support the use of graphic visual warnings but suggest that effects are attenuated for those who smoke the most. The authors offer implications for countermarketing programs and public health policy.
Selenomethionine metabolism and its toxicity in yeast
Authors: Kitajima Toshihiko , Chiba Yasunori
Published: November 2013

The importance of selenium for organisms can be explained by its existence as selenocysteine in the catalytic centers of glutathione peroxidase and thioredoxin reductase. Another selenoamino acid, selenomethionine, is the major form of selenium in foods, and organisms that require selenium as a nutrient directly metabolize selenomethionine to a reactive form of selenium or store it in general proteins. Selenium is recognized as an essential nutrient for human and animal health; however, its excessive uptake harms mammals and the cytotoxic mechanism of selenium remains unclear. Recent progress in the development of selenium-enriched yeast and selenomethionine-resistant mutant to produce selenomethionine-containing proteins for X-ray crystallography has provided new insights into the molecular mechanism of selenomethionine toxicity. In this review, we describe the metabolism of seleno-compounds in yeast and discuss the cytotoxicity caused by selenomethionine against yeast from a metabolic viewpoint.
Mahler measure and elliptic curve L-functions at s = 3
Authors: Lalín Matilde
Published: November 2013

We study the Mahler measure of some three-variable polynomials that are conjectured to be related to
L-functions of elliptic curves at s = 3 by Boyd. The connection with L-functions can be explained with the use of a regulator and a result of Goncharov. Finally, we prove a relationship between two formulas.
Autotopies and quasigroup identities: New aspects of non-associative division algebras
Authors: Darpö Erik , Pérez Izquierdo José Maria
Published: November 2013

In this article, we explore new aspects in the classification of non-associative division
algebras. By a detailed study of the representations of the Lie group of autotopies of real division
algebras we show that, if the group of autotopies has a sufficiently rich structure, then
the algebra is isotopic to one of the classical real division algebras. This turns out to be
the case for large classes of real division algebras, including many that are defined by
identities.
In several cases, a classification up to isomorphism can be worked out from this
information.
Openness to Import and Productivity
Authors: de Boyrie Maria E. , Kreinin Mordechai
Published: November 2013

This article tests the effect of change in the degree of openness to import of goods and services on a country’s productivity. The idea is that by driving resources to industries in which the country has a comparative advantage, imports contribute to increased productivity in the economy. Countries from three distinct regions (OECD, Latin America and Asia), separately and together, were used to test this proposition. A feasible generalized least square estimation method is applied to determine the effect of the capital to labor ratio, openness to imports and real gross domestic product on labor productivity. A panel vector error correction model as proposed by Pesaran et al. (1999) is also performed in order to determine any causal relationship. The effect of imports on labor productivity is found to be positive and significant for the 1990–2011 period under study, strengthening the case for free trade and leading to important policy implications.
Les enfances de Perceval dans le Tristan en prose: jeunesse du héros et genèse du texte
Authors: de Carné Damien , Ferlampin-Acher Christine
Published: November 2013

Les enfances de Perceval racontées par le Tristan
en prose mettent au jour différents problèmes. Inspirées par le Lancelot ou recopiées de lui, selon la version du Tristan que l’on considère, elles ont été généralement jugées comme une simple digression. En outre, cette suite d’épisodes est impliquée dans les relations complexes entre le Tristan et le cycle Post Vulgate, dans la mesure où ce dernier donne sous la même forme une partie de ces aventures. Jetant un nouveau regard sur la version V.I des enfances de Perceval, cette étude montre que la perception d’un écart narratif doit être relativisée. La présentation de Perceval et du meurtre de ses frères s’insère bien dans le Tristan (refus de la transcendance du Graal, dégradation progressive de la cour d’Arthur), ce que confirme une comparaison serrée avec le Lancelot. Du point de vue de la tradition textuelle, sans pouvoir trancher absolument entre les opinions opposées émises par le passé, cette étude réexamine la possibilité que la première version de ces aventures ait été d’origine tristanienne, bien que la forme sous laquelle elle nous est parvenue soit manifestement un développement de la Post Vulgate. En effet, dans ce type de textes mouvants, réfléchir à l’identité textuelle (identité douteuse pour la Post Vulgate, ou du moins la Folie Lancelot) et la matière propre de ces différents romans complète utilement les indices purement philologiques – et facilement contradictoires.
Arthur in Manuscript in Renaissance France: The Case of Ysaïe le Triste, Gotha, MS A 688
Authors: Taylor Jane H. M.
Published: November 2013

Gotha, MS A 688 is currently preserved in the Universitäts- und Forschungsbibliothek Gotha, now kept at the Erfurt University Library in Germany. This is a luxurious manuscript of the neo-Arthurian Ysaïe le Triste: in quarto on paper, copied in a fifteenth- or sixteenth-century bâtarde, and including no fewer than 96 miniatures. The manuscript was probably prepared for Louis II de La Trémouille and his second wife Luisa Borgia, duchesse de Valentinois, both of whose arms are painted on the title page. Prepared perhaps to celebrate their wedding, which took place in 1517, the manuscript must have been produced between 1517 and 1525, Louis having been killed in that year at the battle of Pavia. We have little information on the La Trémouille library, but that said, Louis’s first wife, Gabrielle de Bourbon, was herself an author of several books, and the well-stocked library of Gabrielle’s mother, Gabrielle de La Tour, included copies of Lancelot and Guiron le Courtois.

What is remarkable, however, is the fact that such a lavish manuscript of an Arthurian romance was produced at that time. Not of course that manuscript was obsolete as from the introduction of printing; on the contrary, until much later in the Renaissance, a manuscript, much more than print, represented a very personal gift, for instance, and constituted a prestigious library. That said, only a few Arthurian manuscripts seem to have been produced in sixteenth-century France, let alone manuscripts prepared with such elegance, and of the few that survive, only those produced for the bibliophile Pierre Sala, which he had produced for a modernised Yvain (Paris, BnF MS fr. 1638), and two Tristans (Aberystwyth, National Library of Wales, Add. MS 443-D, and Geneva, Fondation Martin Bodmer, cod. Bodmer 148), all three dating from the 1520s, are of comparable quality. If indeed the Gotha Ysaïe was a gift to Louis and Luisa, it was a lavish gift; we know from a document giving details of expenditures billed by Antoine Vérard for a manuscript printed for Charles of Angoulême, how much such a princely gift might cost. However, the illustrations appear slightly dated: the costumes for example would seem more in the fashion of the mid-fifteenth century. Might our artist have copied an existing suite of miniatures from a manuscript dating from the fifteenth century? Was he simply a provincial artist unfamiliar with the fashions of a new century? These questions are unanswerable – but this manuscript shows, as do the beautiful illustrated manuscrits-imprimés produced for instance by an Antoine Vérard, the prestige enjoyed, even at the heart of the Renaissance, by a beautiful Arthurian manuscript.
Establishing Positive Learning Environments for Students of Chinese American and Latino Backgrounds
Authors: Wong-Lo Mickie , Cortez Gabriel A.
Published: November 2013

Cultivating positive learning environments for underrepresented groups such as students of Chinese American and Latino backgrounds require careful planning and consideration. As our society strives to embrace individual differences of all cultures, educators must equip themselves with effective tools to adapt to the ever-changing dynamics within classrooms. In an effort to bridge research into practice inside the walls of the school campuses, we discuss recommendations for educators who serve students of Chinese American and Latino backgrounds. The recommended practices are highlighted in layers of society, community, school programming, and classroom experience.
Immigrant-Serving Nonprofits and Philanthropic Foundations
Authors: Brown Heath
Published: November 2013

Immigrant-serving nonprofit organizations registered and mobilized thousands of new voters in 2012. These efforts were abetted by philanthropic foundation which, since the early 2000s, have prioritized immigration policy and immigrant issues. Other foundations, hostile to illegal immigration, have funded another set of nonprofits that worked to change immigration policy and voting laws. The article explains these complex relationships between foundations and nonprofits in the context of immigration. The conclusions highlight the tension faced by immigrant-serving nonprofits to maintain their independence and benefit from external funding.
Synthesis and effect of secondary dopant on the conductivity of conducting polymer polyaniline
Authors: Mamma Kedir , Siraj Khalid , Meka Nathan
Published: November 2013

Polyaniline (PANI) in its emeraldine salt form was synthesized by chemical method from aniline monomer in the presence of HCl mixed with LiCl and ammonium persulfate as oxidant. Then, a portion of sample was dedoped with NH3solution and another equal portion was separately postdoped with secondary dopants, such as H2SO4and HClO4, respectively. Finally, the dried samples of PANI prepared in all its three different forms (emeraldine salt form, undoped emeraldine base, and the two secondary doped forms of PANI) were characterized by UV-visible spectroscopy, cyclic voltammetry (CV) techniques, Fourier transform infrared (FT-IR) spectroscopy, and electrical conductivity measurement. The cyclic voltammograms of PANI in its emeraldine base (PANI-EB) determined the electrochemical behavior and the growth mechanisms of the polymer. The FT-IR and UV-vis spectra confirmed the expected structural modification up on doping, undoping, and postdoping processes of the polymer. Their measured electrical conductivities were from 0.02 for undoped, 156 for primary doped form, and increasing from 158 to 257 S/cm for those secondary doped PANI. The influence of secondary doping on the electrical conductivity was also investigated from their spectroscopic data which shows dramatic rise in conductivity. The result also shows that secondary doping increased the π conjugation.
Potential utilization of recycled PET in comparison with liquid crystalline polymer as an additive for HDPE based composite fibers: Comparative investigation on mechanical performance of cross-ply laminates
Authors: Kayaisang Supattra , Amornsakchai Taweechai , Saikrasun Sunan
Published: November 2013

Recycled polyethylene terephthalate (rPET) was used as an alternative reinforcing material for in situ microfibrillar-reinforced polyethylene (PE) based composite fibers and compared with liquid crystalline polymer (LCP). The neat PE and its composites reinforced with LCP and rPET microfibrils under the compatibilizing promotion of 5 wt% styrene-(ethylene butylene)-styrene-grafted maleic anhydride (SEBS-g-MA) compatibilizer, were prepared as fibers using a hot drawing process. Cross-ply laminates of the neat PE and the compatibilized composite fibers were then prepared using a film stacking method. The tensile, flexural and impact performances of each laminate system were examined and compared. Under tensile loading, no significant differences in the initial part of the stress-strain curves, and hence comparable tensile modulus (≈4 GPa) among all laminates, were observed. A difference was only seen in the final part of the curves. For flexural properties, the flexural moduli of the compatibilized LCP- and rPET-composite laminates were nearly the same (≈3 GPa). At high flexural strains (>1%), the different stress-strain behaviors of the laminates were clearly observed. Interestingly, the compatibilized rPET-composite laminate showed much better impact-resistance compared with PE- and compatibilized LCP-laminates. The results demonstrated a high potential for use of the rPET-composite fiber laminate in impact-resistant applications.
On the use of lock-in thermography to monitor delamination growth in composite panels under compression
Authors: Toscano Cinzia , Riccio Aniello , Camerlingo FrancescoPaolo , Meola Carosena
Published: November 2013

The success of composites in automotive, aerospace, and naval applications is mainly related to their aptitude to be tailored to obtain a final product that perfectly fulfills the design requirements. However, during both manufacturing processes and maintenance, some flaws, like delaminations (which may escape simple visual inspection), may be induced in composite structures. The presence of delaminations is of major concern for the load-carrying capability of carbon fiber-reinforced polymer panels. Indeed, delaminations can strongly affect the structural strength and may grow under in-service loads, leading sometimes to catastrophic failures. The aim of this work is to explore the use of lock-in thermography for the monitoring of delamination propagation in composite structures when subjected to generic multiaxial loading conditions. A stiffened composite panel with an embedded skin delamination subjected to compressive loading was taken as a benchmark to assess experimentally the effectiveness of lock-in thermography for monitoring the delamination propagation in situ during the compressive mechanical test. The delamination size as a function of the applied load, observed by lock-in thermography during the execution of the compressive test, was used to validate the results of preliminary numerical computations.
Blended Interaction
Authors: Schwarz Tobias , Butscher Simon , Müller Jens , Reiterer Harald
Published: November 2013

In diesem Beitrag wird Blended Interaction als neuartiger
Ansatz zur ganzheitlichen Gestaltung von Arbeitsumgebungen für
Operateure in Leitwarten vorgestellt. Hintergrund ist die
Herausforderung einer stetig ansteigenden Komplexität der
Mensch-Maschine-Schnittstelle. Leitbild bei der Konzeptentwicklung
sind die Prinzipien der realitätsbasierten Interaktion, die sowohl
den Operateur mit seinen natürlichen Fähigkeiten, als auch den
situativen Kontext der Arbeitsumgebung hervorheben. Darüber hinaus
werden Ergebnisse einer Evaluation mit Anwendern aus
Verkehrsleitzentralen vorgestellt, in welcher ein möglicher
Paradigmenwechsel hin zu neuen Interaktionsformen untersucht
wird.