bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors Influencing Social-Learning Experience in Nearby Pocket Parks On Campus Ground
Authors: Salih Sarah , Ismail Sumarni , Ismail Nor Atiah , Ujang Norsidah , Asif Nayeem
Published: January 2022

Nearby pockets on campus grounds have become necessary learning sustainable settings to improve the academic experience by promoting outdoor social and learning activities. However, many universities still focus mainly on formal indoor learning and lack outdoor education that meets modern academic outcomes. Therefore, the current study aimed to identify the factors affecting students' social-learning experience in nearby pocket parks on campus ground, focusing on the tropical regions. The current study employed a questionnaire survey conducted in three Malaysian universities to collect data from 408 participants. The results showed various types of influencing factors that affect the social-learning experience in nearby pockets on campus ground, including landscape elements and activities, environmental factors, and access to these spaces. The results also indicated that students' demographics, including gender, education status, and university, influenced the outdoor social-learning experience. The current study contributed information to the development of on-campus sustainable settings for integrating nearby pockets in social interaction and learning activities in order to improve the academic social-learning experience.
Effects of Air Pollutants on Mortality of Chronic Kidney Disease Patients with Green Spaces Exposure: A Large Observational Study
Authors: Jung Jiyun , Kim Yong Chul , Lee Hyewon , Shin Sung Joon , Kim Yon Su , Kim Sejoong , Lee Jung Pyo , Kim Ho , Park Jae Yoon
Published: January 2022

With increasing air pollution, the association between green space exposure and health outcomes is a global health concern. The relationship between air pollution and the survival of patients with chronic kidney disease (CKD) who are exposed to residential greenness is yet to be elucidated. This study aimed to determine this relationship in Seoul between 2002 and 2015. A time-varying survival analysis was conducted to investigate the association between long-term exposure to air pollutants and mortality in 29,602 patients with CKD living in residential environments with small and large green infrastructure. The low and high index groups were defined using continuous and percentile thresholds of the satellite data—the derived average Normalized Difference Vegetation Index within 250 m and 1,250 m of residence, respectively. During the observation, 3,863 (14%) deaths occurred. The effect of air pollution exposure on mortality was worse in the low index group than in the high index group. Particularly, exposure to SO2 was associated with increased mortality risk, regardless of the greenness threshold. Consistent results were observed in co-pollutant models. High greenery exposure significantly reduced the risk of air pollution related mortality. Our results emphasize the need for creating environmental infrastructures that include green spaces.
Preliminary Study on Human Adipose Stem Cells Promoting Skin Wound Healing Through Notch1 Signaling Pathway
Authors: Wang Yi , Wu Qinchao , Zheng Yang , Wang Chao , Ding Xu , Wu Heming , Wu Yunong , Zhang Wei , Song Xiaomeng
Published: January 2022

Background: Mesenchymal stem cells (MSCs) have been documented as possible candidates for wound healing treatment because their use could reinforce the regenerative capacity of many tissues. Human adipose stem cells (hADSCs) have the advantages of easy access, large quantity and easy operation. They can be fully applied in the treatment of skin wounds. In this study, we aim to explore the roles and potential mechanisms of hADSCs in cutaneous wound healing.Methods: hADSCs were obtained from human subcutaneous fat. Adipocytes and osteocytes differentiated from hADSCs were determined by staining with Oil Red O and alkaline phosphatase (ALP), respectively. We assessed the effects of hADSCs and hADSC conditional medium (CM) on wound healing in an injury model of mice. Than, we investigated the biological effects of hADSCs on human keratinocytes HaCAT cells in vitro.Results: The results showed that hADSCs could be successfully differentiated into osteogenic and lipogenic cells. hADSCs and hADSCs-CM significantly promote skin wound healing in vivo. hADSCs significantly promoted HaCAT cells proliferation and migration through activating Notch1 signaling pathway, and activated the AKT signaling pathway by Rps6kb1 kinase in HaCAT cells. In addition, we found that hADSCs-mediated activation of Rps6kb1/AKT signaling was dependent on the Notch1 signaling pathway.Conclusion: We demonstrated that hADSCs can promote skin cell-HaCAT cells proliferation and migration via Notch1 pathway, suggesting that hADSCs may provide an alternative therapeutic approach for the treatment of skin injury.
Grasp-Squeeze Adaptation to Changes in Object Compliance Leads to Dynamic Beta-Band Communication Between Primary Somatosensory and Motor Cortices
Authors: CU HUY , LYNCH LAURIE , HUANG KEVIN , TRUCCOLO WILSON , NURMIKKO ARTO
Published: January 2022

In asking the question of how the brain adapts to changes in the softness of manipulated objects, we studied dynamic communication between the primary sensory and motor cortical areas when nonhuman primates grasp and squeeze an elastically deformable manipulandum to attain an instructed force level. We focused on local field potentials recorded from S1 and M1 via intracortical microelectrode arrays. We computed nonparametric spectral Granger Causality to assess directed cortico-cortical interactions between these two areas. We demonstrate that the time-causal relationship between M1 and S1 is bidirectional in the beta-band (15-30Hz) and that this interareal communication develops dynamically as the subjects adjust the force of hand squeeze to reach the target level. In particular, the directed interaction is strongest when subjects are focused on maintaining the instructed force of hand squeeze in a steady state for several seconds. When the manipulandum’s compliance is abruptly changed, beta-band interareal communication is interrupted for a short period (~ 1 second) and then is re-established once the subject has reached a new steady state. These results suggest that transient beta oscillations can provide a communication subspace for dynamic cortico-cortical S1-M1 interactions during maintenance of steady sensorimotor states.
WITHDRAWN: The Value of Lung Ultrasound Score Predicts the Ventilator use in Preterm with Dyspnea within 24h after Hospitalization
Authors: zhang lihua , Feng jinnan , jin di , yu zekun , qu mingyang , zheng meiyu , Wu Hui
Published: January 2022

This study aims to explore the predictive value of LUSsc(Lung Ultrasound Score) in the selection of respiratory support mode for premature infants with dyspnea.We prospectively included 857 preterm infants and performed LU in the first 2 hours of admission and scored LUSsc by two specialist sonographers. They were divided into two stratification according to gestational age (<32 +0 weeks and 32 +0 -36+6 weeks), and had two main outcomes: invasive and non-invasive respiratory support. In the training set, analysis the clinical factors finding the best cut-off value of lung ultrasound score then verified the consistency in the verification set. The choice of invasive respiratory support is based on neonatal mechanical ventilation rules. Preterm infants with invasive respiratory support had higher LUS scores and lower OI 、birth weight、than those with non-invasive support. For preterm <32 +0 weeks the cut-off point of LUSsc was 6.5 that the area under curve was 0.749 (95% CI: 0.689-0.809), which was statistically significant (P<0.05), and the sensitivity and specificity were 74.0% and 68.3%, for preterm 32 +0 -36 +6 weeks, cut-off point was 6.5 and the area under curve was 0.863 (95% CI: 0.811-0.911), sensitivity and specificity were 75.3% and 0.836%.In the validation set, use actual clinical respiratory support selection results to verify, for preterm <32 +0 weeks (Kappa value 0.660, P<0.05, McNemar test P ＞0.05),for preterm 32 +0 -36 +6 weeks (Kappa value 0.779, P<0.05, McNemar test P ＞0.05).
Conclusion:
The LUS score shows good reliability to predict respiratory support mode for preterm infants with dyspnea
The Rare Cry For Help: First Record of An Agonistic Call From A Snake In South America
Authors: Fernandes Igor Yuri , Koch Esteban Diego , Mônico Alexander Tamanini
Published: January 2022

Discussions about auditory systems and sound dynamics in snakes are frequent. The known frequency of sounds produced by snakes ranges from 0.2 - 7.5 KHz, ranging from imperceptible sounds to humans to audible and observable squeaks. The hiss and whistles are the most common sound and are not considered vocalizations. During a nocturnal survey on June 13, 2021, in the northern Brazilian Amazon, we observed the first record of vocalization in a South American snake. Emitted by the individual from Dipsas catesbyi has a duration of 0.06 seconds, reaching 3036 Hz in its peak frequency, with an amplitude of 2761 to 4152 Hz of frequency in its main emission. Vocalizations were made during the exhalation of air through the larynx. The modulation differs from all patterns observed for snakes resembling the agonistic call of anuran amphibians, which could characterize an evolutionary mimicry of this behavior. Vocal emission via the larynx can generate internal vibrations perceptible to the auditory system of snakes, which, when vocalizing, vibrate the laryngeal cartilage and vocal cord. Our hypothesis is that structured vocal emission through laryngeal air exhalation may be a characteristic shared by other species of the Colubridae family.
Triamcinolone Acetonide-Loaded Nanoparticles Encapsulated By CD90+ MCSs-Derived Microvesicles Drive Anti-Inflammatory Properties and Promote Cartilage Regeneration After Osteoarthritis
Authors: Li Yuanlong , Tu Qingqiang , Xie Dongmei , Chen Shurui , Gao Kai , Xu Xiaochun , Zhang Ziji , Mei Xifan
Published: January 2022

Background: Osteoarthritis (OA) is a highly prevalent human degenerative joint disorder that has long plagued patients. Glucocorticoid injection into the intra-articular (IA) cavity provides potential short-term analgesia and anti-inflammation, but long-term IA causes loss of cartilage content. Synovial mesenchymal stem cells (MSCs) reportedly promote cartilage proliferation and increase cartilage content. Methods: The CD90+ MCSs-derived micro-vesicle (CD90@MV)-coated nanoparticle (CD90@NP) was developed. CD90+ MCSs were extracted from human synovial tissue. Cytochalasin B (CB) relaxed the interaction between the cytoskeleton and the cell membranes of CD90+ MCSs, stimulating CD90@MV secretion. The poly (lactic-co-glycolic acid) (PLGA) nanoparticle was coated with CD90@MV, and a model glucocorticoid, triamcinolone acetonide (TA), was encapsulated in CD90@NP (T-CD90@NP). Results: CD90@MV membrane proteins were similar to CD90+ MCSs, indicating that the CD90@MV bio-activity is similar to the cartilage proliferation-inducing CD90+ MCSs. The CD90@NP binding to injury cartilage primary cells was significantly stronger than the erythrocyte membrane-coated nanoparticles (RNP). In the rabbit OA model, long-term IA of T-CD90@NP showed significantly enhanced repair of damaged cartilage than TA and CD90+ MCSs treatments. In the rat OA model, short-term IA of T-CD90@NP showed effective anti-inflammatory ability similar to TA treatment. Moreover, long-term IA of T-CD90@NP induced cartilage to restart the cell cycle and reduced cartilage apoptosis. T-CD90@NP promotes regeneration of chondrocytes, reduces apoptosis via the FOXO pathway, and influences type 2 macrophage polarization to regulate inflammation through IL-10. Conclusion: This study confirms that T-CD90@NP promotes chondrocyte proliferation and anti-inflammation, improving the clinical glucocorticoid treatment plan.
Defect Detection of Mechanical Design Products Using Deep Neural Network
Authors: Jan Mian Ahmad
Published: January 2022

In industrial production, defect detection is one of the key methods to control the quality of mechanical design products. Although defect detection algorithms based on traditional machine learning can greatly improve detection efficiency, manual feature extraction is required and the design process is complicated. With the rapid development of CNN, major breakthroughs have been made in computer vision. Therefore, building a surface defect detection algorithm for mechanical design products based on DCNNs plays a very important role in improving industrial production efficiency. This paper studies the surface defect detection algorithm of mechanical products based on deep convolutional neural network, focusing on solving two types of problems: defect recognition and defect segmentation. Aiming at the problem of defect recognition, this paper studies a defect recognition algorithm based on fully convolutional block detection. This algorithm introduces the idea of block detection into the ResNet fully convolutional neural network. While realizing the local discrimination mechanism, it overcomes the shortcomings of the traditional block detection receptive field. Compared with the original ResNet image classification algorithm, this algorithm has stronger generalization ability and detection ability of small defects. Aiming at the problem of defect segmentation, this paper studies a defect segmentation algorithm based on improved Deeplabv3+.
Increased Levels of PD1 and Glycolysis in CD4+ T Cells Promote Lymph Node Metastasis in Oral Squamous Cell Carcinoma Patients
Authors: Wu Kun , Han Nan-nan , Zhang Sheng , Li Yan
Published: January 2022

Background: Cervical lymph node metastasis is one of the poorest prognostic factors in oral squamous cell carcinoma (OSCC). Activated immune cells and cancer cells generally have metabolic similarities in tumor microenvironment. However, it is unknown whether abnormal glycolysis in T cells could facilitate metastatic lymph nodes in patients with OSCC. Methods: Flow cytometry and immunofluorescence staining were used to analyze the differences in CD4+ PD1+ T cells between metastatic and negative lymph nodes. RT-PCR was performed to detail the expression of immune checkpoints and glycolysis-related enzymes in metastatic and negative lymph nodes. Kruskal-Wallis, Mann-Whitney, or nonparametric paired tests (i.e., the Wilcoxon matched paired test) were used to analyze the non-parametric distribution of the samples. Results: The frequency of CD4+ T cells decreased in the metastatic lymph nodes (p = 0.0019). Immune checkpoints (PD1, PDL1, and CTLA4) of CD4+ T cells were detected in metastatic (LN+) and paired negative lymph nodes (LN-) of OSCC patients. The PD1 expression of LN+ increased markedly compared to that of LN- (p = 0.0205). Similarly, the PD1 of CD4+ T cells in LN+ increased significantly compared to that of LN-. Glycolysis-related enzyme levels in CD4+ T cells from LN+ were dramatically higher than those in LN-. Moreover, PD1 and Hk2 expressions in CD4+ T cells increased in metastatic lymph nodes of OSCC patients with prior surgical treatment compared to those without. Conclusions: These findings suggest that increased PD1 and glycolysis in CD4+ T cells may serve as pivotal regulators of OSCC metastatic lymph nodes, which are closely associated with elevated glycolysis.
PCOS: a Chronic Disease That Fails to Produce Adequately Specialized Pro-resolving Lipid Mediators (SPMs).
Authors: Regidor Pedro-Antonio , Rosa Xavier de la , Mueller Anna , Sailer Manuela , Santos Fernando Gonzalez , Banzo Rafael Gracia , Rizo Jose Miguel
Published: January 2022

Introduction: Polycystic Ovary Syndrome (PCOS) is an endocrinologic disorder that affects 5-15 % of women of their reproductive age and is a frequent cause of infertility. Major symptoms include hyperandrogenism, ovulatory dysfunction, and often obesity and/or insulin resistance. PCOS also represents a state of chronic low-grade inflammation that is closely interlinked with the metabolic features. "Classical" pro-inflammatory lipid mediators like prostaglandins (PG), leukotrienes (LT), or thromboxanes (TX) are derived from arachidonic acid (AA) and are crucial for the initial response. Resolution processes are driven by four families of so-called specialized pro-resolving mediators (SPMs): resolvins, maresins, lipoxins, and protectins. The study aimed to establish lipid mediator profiles of PCOS patients compared to healthy women to identify differences in their resolutive and pro-inflammatory lipid parameters. Material and Methods: Fifteen female patients (18-45 years) were diagnosed with PCOS according to Rotterdam criteria, and five healthy women, as comparator group, were recruited for the study. The main outcome measures were: Pro-inflammatory lipid mediators (PG, LT, TX) and their precursor AA; SPMs (Resolvins, Maresins, Protectins, Lipoxins), their precursors EPA, DHA, DPA, and their active biosynthesis pathway intermediates (18-HEPE, 17-HDHA, 14-HDHA).Results: The level of pro-inflammatory parameters in serum was significantly higher in PCOS-affected women. The ratio [(sum of pro-inflammatory molecules) / (sum of SPMs plus hydroxylated intermediates)] reflecting the inflammatory state was significantly lower in the group of healthy women.Conclusion: There is a strong pro-inflammatory state in PCOS patients. Further research will clarify whether supplementation with SPMs or their precursors may improve this state.
A Highly Fluorescent Pyrene-based Sensor for Selective Detection of Fe3+ Ion in Aqueous Medium: DFT and Molecular Docking Studies
Authors: Rasin Puthiyavalappil , Mathew Merlin Mary , Manakkadan Vipin , Palakkeezhillam Vishnunarayanan Namboothiri Vadakkedathu , Anandaram Sreekanth
Published: January 2022

In this work, we introduce a highly selective and sensitive fluorescent sensor based on pyrene derivative for Fe(III) ion sensing in DMSO/water media. 2-(pyrene-2-yl)-1-(pyrene-2-ylmethyl)-1H-benzo[d]imidazole (PEBD) receptor was synthesized via simple condensation reaction and confirmed by spectroscopic techniques. The receptor exhibits fluorescence quenching in the presence of Fe(III) ions at 440 nm. ESI-MS and Job’s method were used to confirm the 1:1 molar binding ratio of the receptor PEBD to Fe(III) ions. Using the Benesi-Hildebrand equation the binding constant value was determined as 8.485×103 M-1. Furthermore, the limit of detection (LOD, 3σ/K) value was found to be 1.81µM in DMSO/water (95/5, v/v) media. According to the Environmental Protection Agency (EPA) of the United States, it is lower than the acceptable value of Fe3+ in drinking water (0.3 mg/L). The presence of 14 other metal ions such Co2+, Cr3+, Cu2+, Fe2+, Hg2+, Pb2+, K+, Ni2+, Mg2+, Cd2+, Ca2+, Mn2+, Al3+, and Zn2+ did not interfere with the detection of Fe(III) ions. Computational studies of the receptor PEBD were carried out with density functional theory (DFT) using B3LYP/ 6-311G (d, p), LANL2DZ level of theory. Finally, molecular docking studies have been performed to investigate the Cytochrome P450 1A1(CYP1A1) protein inhibitory action of the receptor PEBD.
Preoperative S-1 Therapy for Squamous Cell Carcinoma of The Head and Neck During the Waiting Period Before Surgery
Authors: Matsuki Takashi , Fushimi Chihiro , Miyamoto Shunsuke , Takahashi Hideaki , Masubuchi Tatsuo , Tada Yuichiro , Miura Kouki , Kamata Shin-etsu , Kano Koichi , Tsutsumi Shohei , Momiyama Kaho , Yamashita Taku
Published: January 2022

Background: In patients with squamous cell carcinoma of head and neck (SCCHN), delayed surgery can result in poorer postoperative function and prognosis due to the growth of the tumor and the extended surgery. Further, delay may even make the tumor unresectable. To prevent tumor growth during the waiting period before surgery, S-1 has been administrated preoperatively at several facilities in Japan. To date, however, the safety and efficacy of preoperative S-1 remains unclear.Methods: We conducted a retrospective cohort study of 118 patients with SCCHN treated with S-1 before radical surgery at 2 institutions in Japan. We evaluated the safety of S-1 therapy, which was evaluated by the incidence of grade 3 or greater adverse events (AEs). The rate of achievement of the non-growth of tumors was also calculated.Results: Regarding safety, 125 AEs of all grades were recorded in 71 patients (60%). Of these, grade 3 AEs were detected in 3 patients (3%), and no grade 4 or 5 AEs occurred. The non-growth rate of primary lesions and lymph node metastases was 89% and 85%, respectively. Conclusion: Our data showed that preoperative S-1 therapy might be useful with acceptable toxicity on an outpatient basis in patients with SCCHN.
Early Markers of Cardiovascular Disease Associated With Clinical Data and Autosomal Ancestry in Patients With Type 1 Diabetes: A Cross-sectional Study in an Admixed Brazilian Population.
Authors: Reis Roberta Maria Duailibe Ferreira Reis , Silva Dayse Aparecida , Tavares Maria da Glória , Nascimento Gilvan Cortês , Damianse Sabrina da Silva Pereira , Rocha Viviane Chaves de Carvalho , Almeida Ana Gregória , Lago Débora Cristina Ferreira , Rodrigues Vandilson , Magalhães Marcelo , Sobral Carla Souza , Parente Conceição , França Joana , Ribeiro Jacqueline , Ferraz Paulo Cézar Dias , Azulay Carlos , Gomes Marília Brito , Faria Manuel dos Santos , Azulay Rossana Santiago de Sousa
Published: January 2022

BackgroundPatients with type 1 diabetes (T1D) have a higher risk of developing cardiovascular disease (CVD), which is a major cause of death in this population. The objective of this study was to investigate early markers of CVD associated with clinical data and autosomal ancestry in T1D patients from an admixed Brazilian population. MethodsA cross-sectional study was conducted with 99 T1D patients. The early markers of CVD included the ankle-brachial index (ABI), coronary artery calcium score (CACS), and carotid Doppler sonography. Demographic, clinical, and serum data were collected. A panel of autosomal informational insertion/deletion ancestry markers was used to estimate the individual proportions of European, African, and Amerindian ancestry.ResultsThe study sample had a mean age of 27.6 years and 14.4 years of duration of T1D. The prevalence of alterations in early CVD markers was: ABI (< 0,9) 19.6%, CACS (> 0 +) 4.1%, and carotid Doppler 5.0%. There was significant agreement between CACS and carotid Doppler, and these were correlated with traditional risk factors for CVD. There was a predominance of European ancestry (47.3%), followed by African (28%) and Ameridian (24.7%). There were no association between early CVD markers and autosomal ancestry proportions.ConclusionThe ABI was useful in the early identification of CVD in asymptomatic young patients with T1D and with a short duration of disease, and showed agreement with the carotid Doppler. Although CACS and carotid Doppler are non-invasive tests, carotid Doppler is more cost-effective, and both have limitations in screening for CVD in young patients with a short duration of T1D. We did not find a statistically significant relationship between autosomal ancestry proportions and early CVD markers in an admixed Brazilian population.
Identification of Molecular Biomarkers Associated With Stroke Progression Using WGCNA and SVM-RFE
Authors: Liu Si-tong , Zhang You , Wu Xin-gui , Lu Chang-xing , Hu Qi-Ping
Published: January 2022

Background: Stroke is the second most common cause of death worldwide and the leading cause of long-term severe disability with neurological impairment worsening within hours after stroke onset and being especially involved with motor function. So far, there are no established and reliable biomarkers to prognose stroke. Early detection of biomarkers that can prognose stroke is of great importance for clinical intervention and prevention of clinical deterioration of stroke.Methods: TGSE119121 dataset was retrieved from the Gene Expression Integrated Database (Gene Expression Omnibus, GEO) and weighted gene co-expression network analysis (WGCNA) was conducted to identify the key modules that could regulate disease progression. Moreover, functional enrichment analysis was conducted to study the biological functions of the key module genes. The GSE16561 dataset was further analyzed by the Support Vector Machines coupled with Recursive Feature Elimination (SVM-RFE )algorithm to identify the top genes regulating disease progression. The hub genes revealed by WGCNA were associated with disease progression using the receiver operating characteristic curve (ROC) analysis. Subsequently, functional enrichment of the hub genes was performed by deploying gene set variation analysis (GSVA). The changes at gene level were transformed into the changes at pathway level to identify the biological function of each sample. Finally, the expression level of the hub gene in the rat infarction model of MCAO was measured using RT-qPCR for validation. Results: WGCNA analysis revealed four hub genes: DEGS1, HSDL2, ST8SIA4 and STK3. The result of GSVA showed that the hub genes were involved in stroke progression by regulating the p53 signal pathway, the PI3K signal pathway, and the inflammatory response pathway. The results of RT-qPCR indicated that the expression of the four HUB genes was increased significantly in the rat model of MCAO.Conclusion: Several genes, such as DEGS, HSDL2, ST8SIA4 and STK3, were identified and associated with the progression of the disease. Moreover, it was hypothesized that these genes may be involved in the progression stroke by regulating the P53 signal, the PI3K signal, and the inflammatory response pathway, respectively. These genes have potential prognostic value and may serve as biomarkers for predicting stroke progression. The early identification of the patients at risk of progression is essential to prevent clinical deterioration and provide a reference for future research.
Immediate Postoperative Single-Dose Intravenous Ferric Carboxymaltose After Autologous Free-Flap Breast Reconstruction: A Prospective Cohort Study With Propensity Score Matching
Authors: Park Joseph Kyu-hyung , Lee Seungjun , Heo Chan Yeong , Jeong Jae Hoon , Myung Yujin
Published: January 2022

Intravenous ferric carboxymaltose (IV-FCM) can effectively correct perioperative anemia in patients undergoing major surgeries. However, its efficacy and side effects in patients undergoing free flap-based breast reconstruction are yet to be investigated. Starting from year 2020, patients with breast cancer undergoing abdominal free flap-based breast reconstruction were injected 500 mg of IV-FCM immediately post-operation. Propensity-matched 82 IV-FCM injected (study group) and 164 historical control group patients were analyzed for transfusion rates, changes in hematological parameters, and flap or donor-site related complications. The major and minor complication rates related to the operation site were similar between the two groups. There was no significant difference in the transfusion rate between the two groups (p = 0.71). However, the total amount of transfusion required was significantly higher in the historical control group (p = 0.02) than in the study group. Additionally, the historical control group showed a significantly higher drop in red blood cell count, hemoglobin, and hematocrit levels from postoperative days 1 to 2 and 2 to 3 compared to the study group. Immediate postoperative use of IV-FCM in free flap-based breast reconstruction was well tolerated by patients, reduced overall transfusion volume, and promoted faster postoperative recovery of hematological parameters.
Response Surface Grey Relational Analysis On The Manufacturing of High Grade Biomedical Ti-13Zr-13Nb
Authors: Abifarin Johnson Kehinde , Fidelis Fredah Batale , Abdulrahim Moshood Yemi , Oyedeji Elijah Oyewusi , Nkwuo Tochukwu , Prakash Chander
Published: January 2022

Optimization of the manufacturing conditions with more than one performance characteristics have been a thing of concern, especially for Response Surface Method (RSM) optimization. Hence, this study addressed this challenge by reanalyzing a data presented in a previous study using grey relational analysis (GRA) and regression analysis. Central Composite Design (CCD) of RSM with high and low values of manufacturing conditions; voltage (50, 70) V, current (8, 16) A, pulse ON time (6, 10) μs, and pulse OFF time (7, 11) μs. The manufacturing conditions for optimal biomedical Ti-13Zr-13Nb alloy were obtained to be 50V voltage, 8A current, 6 μs pulse ON time, and 11 μs pulse OFF time. It was also revealed that the mathematical model was very efficient because the modeled GRG was in consonant with the experimental one. In addition, it was also established that current was the most significant manufacturing condition with a contribution of 47.27%. Voltage, factors interactions and residual error were insignificant on the GRG value of the titanium alloy. In conclusion, it can be deduced that the a small value of voltage within the considered settings could be used to manufacture better grade Ti-13Zr-13Nb alloy and also the small value of residual error showed the high manufacturability of the material.
Spatial-dependent Quantum Dot-photon Entanglement via Tunneling Effect
Authors: joughi Yaser Delir ghaleh , Sahrai Mostafa
Published: January 2022

Utilizing the vortex beams, we investigate the entanglement between the triple-quantum dot molecule and its spontaneous emission field. We present the spatially dependent quantum dot-photon entanglement created by Laguerre-Gaussian (LG) fields. The degree of position-dependent entanglement (DEM) is controlled by the angular momentum of the LG light and the quantum tunneling effect created by the gate voltage. Various spatial-dependent entanglement distribution is reached just by the magnitude and the sign of the orbital angular momentum (OAM) of the optical vortex beam.
Unmet Health Need Among Roma: Visual Acuity and the Use of Vision Correcting Aids in the Hungarian Roma Population
Authors: Losonczy Gergely , Piko Peter , Klevering B. Jeroen , Kosa Zsigmond , Sandor Janos , Adany Roza
Published: January 2022

The Roma population is the largest transnational ethnic minority group in Europe often facing socioeconomic inequalities and various health problems. In the present study we investigated the visual acuity and its affecting factors along with spectacle use of the Roma in comparison with the general population in Hungary.A cross-sectional survey was carried out including 832 participants aged 20 to 64 years. We recorded the visual acuity, anthropometric, demographic, socioeconomic and health-related data of each individual. Although the average uncorrected visual acuity was somewhat higher, the use of a visual aid was significantly less frequent in the Roma population, especially in the group with a visual acuity below 0.5 in both eyes (14.3% vs 77.1%, p<0.001). Age, abdominal obesity and disturbances of the carbohydrate metabolism had a negative impact on visual acuity in both populations, however, the latter was a much stronger risk factor in the Roma population (OR: 5.789, 95% CI: 2.239-14.964, p<0.001) than in the general population (OR: 2.075, 95% CI: 1.097-3.926, p=0.025). Our results show serious unmet health needs within the Roma population, which calls for public health programs to improve poor primary care indicators on regular eye examination, and a much more rigorous diabetes control.
Oxaliplatin-Induced Peripheral Neuropathy Can Be Minimized By Pressurized Regional Intravascular Delivery In An Orthotopic Murine Pancreatic Cancer Model.
Authors: Narayanan Jayanth Surya Narayanan Shankara , Frizzi Katie , Erdem Suna , Ray Partha , Jaroch David , Cox Bryan , Katz Steven , Vicente Diego , White Rebekah R.
Published: January 2022

Purpose: There is a great need to reduce the toxicity of chemotherapy used in the management of pancreatic ductal adenocarcinoma (PDAC). Here we explore if regional pressurized delivery of oxaliplatin can minimize peripheral neuropathy in mice.Methods: We used an orthotopic PDAC mouse model and delivered a single dose of oxaliplatin through the portal vein using a pressure-enabled system (pancreatic retrograde venous infusion, PRVI). We analyzed the effects of PRVI on tumor burden and peripheral neuropathy using histopathological and functional assays.Results: Tumor weights in mice treated with 2 mg/Kg oxaliplatin using PRVI were significantly lower than in mice treated with the same dose systemically. This resulted in reduced peripheral neuropathy signatures in PRVI mice compared to the 20 mg/Kg systemic dose required to achieve similar tumor control.Conclusion: Regional delivery of highly cytotoxic agents using PRVI can reduce the therapeutic dose of these drugs, thereby lowering toxic side effects.
Bacteriological Identification among Patients Attending at Jimma University Veterinary Clinic
Authors: Ayana Gelana Urgesa , Tesfaye Boka
Published: January 2022

Findings of conducted study showed that the predominant bacteria in Jimma University Veterinary Clinic. Among predominant bacteria identified includes; Escherichia coli 46 (34.3%), Klebsiella 23(17.2%), followed by Staphylococcus aureus 40(29.9%) and Streptococcus spp 25(18.7%). Among 4 species of bacteria isolated, 2 were gram negative and 2 of them was gram positive bacteria. Among the antibiotic susceptibility test, Staphylococcus aureus showed the total resistant on penicillin while tetracycline showed to have the highest sensitivity. Escherichia coli showed the total resistant on gentamicin (100%). Veterinary Clinic is at risk of acquiring bacterial infections due to the presence of mentioned bacteria during this study. The big issue is that these infections resist to antibiotics used in treatment according to results of the study. Health care workers in Veterinary Clinic should improve hygiene to control clinic acquired infections and much attention should be done during diagnosis to improve treatment of patients.
Giant bladder stone resulting in acute kidney injury; a case report and review of literature
Authors: Gebrehiwot Fitsum Gebreegziabher , Adem Mubarek Bargicho , Issack Feysel Hassen , Gebresellasie Kaleab Habtemichael , Mummed Ferid Ousman , Hassen Ibsa Kedir
Published: January 2022

A giant bladder stone is very rare in adults. We report a case of giant bladder stone causing acute kidney injury in a 23-year-old male, who presented with lower urinary tract symptoms (LUTS) characterized by both irritative and obstructive LUTS. In addition, he also had episodes of reddish urine for the past decade. A non-contrast-enhanced CT scan was used for the diagnosis. Open cystolithotomy was performed and a 500g weighing stone was removed. He developed a superficial surgical site infection which was treated with wound care. He was discharged improved. Improvement in symptoms and serum creatinine was noted on follow-up.
Evaluation of Preventive Measures and Forecasting of COVID-19 Infection: Case Study Egypt.
Authors: Khaled Safaa A A , Hafez Ahmed A A
Published: January 2022

Background

COVID-19 is a highly infectious disease caused by SARS-CoV-2. This article assessed the effectiveness of preventive measures of COVID-19 infection, including social distancing (SD) and quarantine (Q) of patients and contacts in Egypt.
Methods

A simple model was developed to predict the infection rate without preventive measures. The article utilizes fertile meta- heuristic technique and particle swarm optimization (PSO), to predict the growth of the disease.
Results

A correlation between the predicted and actual infected cases, validated the proposed forecasting algorithm. Preventive measures together with the Egyptian Government stay home order reduced 98% of expected infections. PSO analyses showed that infection and death rates will continue to increase particularly with lifting these restrictive preventive measures.
Conclusions

The advised PSO model could predict COVID-19 infection and death rates with high degree of accuracy. This prediction model could help health authorities in decision making.
Using Ultrasound Guided Needle Biopsy in Combination With GeneXpert MTB/RIF to Diagnose Epididymal Tuberculosis: a Study of 12 Cases
Authors: Qinghu Yan , Jia Cui , Bo Liang , Binbin Feng , Wuzhang Wang , Dexin Yu , Yan'an Zhang
Published: January 2022

Objective: This study aims to investigate the diagnostic utility of percutaneous ultrasound-guided needle biopsy in combination with GeneXpert MTB/RIF for epididymal tuberculosis.Methods: Between March 2019 to March 2021, specimens obtained from 12 patients with confirmed epididymal tuberculosis by ultrasound guided needle biopsy were sent for pathology and laboratory examination at the Shandong Public Health Clinical Center. The laboratory examination included acid-fast staining, Mycobacterium tuberculosis culture by BACTEC MGIT 960, and the GeneXpert MTB/RIF test. The diagnosis and complications were comprehensively analyzed.Results: Among the 12 cases, seven cases had granulomatous inflammation and necrotic tissue, four cases had chronic inflammatory cells and necrotic tissue, and one case had chronic inflammatory cell infiltration. Furthermore, among the 12 patients, five patients were positive for Mycobacterium tuberculosis culture, two patients were positive for the acid-fast staining, and twelve patients were positive for the GeneXpert MTB/RIF assay. The sensitivity and specificity of the acid-fast staining, Mycobacterium tuberculosis culture and GeneXpert MTB/RIF in the diagnosis of epididymis tuberculosis were 16.67% and 100.00%, 41.67% and 100.00%, and 100.00% and 50.00%, respectively. The diagnostic value analysis of the three detection techniques indicated that the GeneXpert MTB/RIF technique (Kappa=0.63, AUC=0.75) is superior to the Mycobacterium tuberculosis culture (Kappa=0.17, AUC =0.71) and acid-fast staining (Kappa=0.05, AUC=0.58). Conclusion: Ultrasound guided percutaneous biopsy combined with GeneXpert MTB/RIF assay is extremely useful for diagnosing epididymitis tuberculosis and determining rifampin resistance, with superior sensitivity, specificity and AUC value.
Procalcitonin-Guided Treatment Regarding Antibiotic Use for Acute COPD Exacerbations (PRECISION): Study Protocol for a Prospective Randomized Controlled Trial.
Authors: Schaik Michael van , Veen Hans in 't , Brusselle Guy , Boersma Wim , Bresser Paul , Reijers Monique , Dooren Yordi van , Djamin Remco , Melle Marloes de Vries - van , Berg Jan Willem van den , Mölken Maureen Rutten - van , Boersma Eric (H) , Eerden Menno van der , Aerts Joachim
Published: January 2022

Background: Chronic Obstructive Pulmonary Disease (COPD) is a worldwide prevalent disease. It is estimated to be the 3rd leading cause of death worldwide in 2020, and it is also a leading cause of disability-adjusted life years (DALY’s). COPD accounts for just over 3% of the total health care budget in the European Union. The majority of these costs are attributed to acute exacerbations of COPD (AECOPD). Given the contribution of exacerbations, it is of paramount importance to improve the current treatment of exacerbations to reduce the burden of disease for patients (mortality and DALY’s) and for society (costs). Treatment of AECOPD generally consists of corticosteroids and antibiotics, mostly in one-size fits all fashion. Pulmonary physicians are well aware of overuse of antibiotics, but lack the tools to decide which medication to give. Biomarkers may aid towards a more personalized treatment of AECOPD by identifying which patient would benefit from antibiotics. Procalcitonin (PCT) is the precursor of calcitonin and is released in response to a bacterial infection. PCT levels are minimally raised in viral infections, making it a relative specific diagnostic tool for bacterial infections. Several trials have shown a reduction in antibiotic consumption in AECOPD when using a PCT-guided treatment algorithm. One meta-analysis suggested that PCT-based protocols may be superior to standard care, but the authors stated that appropriately powered confirmatory trials are necessary. The objective of our study is to assess that at hospitalization for a severe AECOPD, PCT-guided treatment to guide antibiotic administration is non-inferior to usual care, in terms of treatment failure at day 30. Methods: The study is set up as a prospective randomized trial. A total of 693 patients with a severe exacerbation of COPD will be included and randomized between usual care and PCT-guided treatment regarding antibiotic therapy. The primary endpoint will be treatment failure within 30 days after inclusion, the endpoint comprises disease-related mortality and other disease-related adverse events. Discussion: We believe this trial can add to the currently available evidence with PCT being tested in a clinical setting in a treatment algorithm specifically in COPD with the primary objective being treatment failure. Trial registration: Netherlands Trial Register. Registration number: NL9122. Date of registration: 24-11-2020. URL of trial registry record: https://www.trialregister.nl/trial/9122
Handling Compassion Fatigue in Complaint and Referral Unit Volunteers: Case Study of Komnas Perempuan
Authors: Adiningsih Hana Berliani , Abidin Zainal
Published: January 2022

The spiking exposure of traumatic events faced by workers and volunteers in handling violence against women has the potential to lead to compassion fatigue. This research sought to describe the experience and protective factors of compassion fatigue in Complaint and Referral Unit volunteers who provide services to female victims of violence in Komnas Perempuan. A total of 3 respondents participated in this study through online interview. Thematic analysis is performed to analyze the data. The result suggested that the participants had compassion fatigue symptoms, which included burnout and secondary traumatic stress symptoms. The experience of burnout included physical and emotional exhaustion as well as guilt and helplessness. Whereas secondary traumatic stress was expressed in preoccupation of thoughts about victim’s violence case and projection in personal relationships. Nevertheless, these symptoms had been resolved due to protective factors such as personal characteristics (educational background and self-care) and social support (personal and professional support from the organization). This study added to our knowledge on how to create supportive system for volunters who provide services for victims of violence against women.
Hydrogen solubility in FeSi alloy phases at high pressures and temperatures
Authors: Fu Suyu , Chariton Stella , Prakapenka Vitali B. , Chizmeshya Andrew , Shim Sang-Heon
Published: January 2022

Light elements alloying with metallic Fe can change the properties and therefore play a key role in the structure and dynamics of planetary cores. Hydrogen and silicon are possible light elements in the rocky planets’ cores. However, hydrogen storage in Fe-Si alloy systems remains unclear at high pressures and high temperatures because of experimental difficulties. Taking advantage of pulsed laser heating combined with high-energy synchrotron X-ray diffraction, we studied reactions between FeSi and H in laser-heated diamond-anvil cells (LHDACs) up to 61.9 GPa and 3500 K. We found that under H-saturated conditions the amount of H alloying with FeSi (0.3 and <0.1 wt% for the B20 and B2 structures, respectively) is much smaller than that in pure Fe metal (>1.8 wt%). Our experiments also suggest that H remains in the crystal structure of FeSi alloy when recovered to 1 bar. Further density functional theory (DFT) calculations indicate that the low-H solubility likely results from the highly distorted interstitial sites in the B20 and B2 structures, which are not favorable for H incorporation. The recovery of H in the B20 FeSi crystal structure at ambient conditions could open up possibilities to understand geochemical behaviors of H during core formation in future experiments. The low-H content in FeSi alloys suggests that if a planetary core is Si-rich, Si can limit the ingassing of H into the Fe-rich core.
Litigiosidad climática: investigaciones sobre mecanismos jurisdiccionales en defensa de los derechos climáticos. Primera Parte
Authors: Porcelli Adriana Margarita , Martínez Adriana Norma
Published: January 2022

El presente artículo tiene por objeto analizar las sentencias nacionales que se pronunciaron sobre la legitimación activa para demandar tanto a los Estados como a particulares para exigir el cumplimiento de los compromisos climáticos y la efectiva condena pecuniaria por contribuir con el cambio climático, basándose en la afectación a los derechos humanos. Por lo extenso de la investigación y análisis, el trabajo se presenta en dos partes diferenciadas: una primera, general, en la que se desarrolla el marco conceptual consistente en definir la terminología litigiosidad climática, casos comprendidos, excluidos y los antecedentes jurisprudenciales hasta el año 2020. Y la segunda, que describe el estado actual de los litigios climáticos, especialmente, dos de las últimas sentencias novedosas por su implicancia: la pionera resolución del Tribunal Administrativo de París, febrero de 2021, que responsabilizó a Francia por inacción frente a la lucha contra el cambio climático y la del Tribunal de Distrito de La Haya, en mayo de 2021, que consideró que la compañía matriz Royal Dutch Shell-como responsable de las políticas del grupo Shell- ocasionaba un daño ambiental inminente al no adoptar medidas suficientes para reducir sus emisiones de dióxido de carbono y le ordenó reducir dichas emisiones en un 45% neto para fines del 2030 en comparación con los niveles de 2019, a través de la política corporativa del grupo incluidos sus proveedores y clientes. La metodología se basó en el método científico, en la investigación bibliográfica y jurisprudencial referida a la temática. Se concluyó que, si bien en la actualidad no se percibe claramente la gravedad del cambio climático, la pandemia presenta oportunidades hacia una reconstrucción mundial más sostenible y las sentencias contra Francia y contra el grupo Shell constituyen un punto de inflexión hacia la condena de los Estados y empresas.
Revisión sistemática del análisis del marco legal peruano en el ámbito del acoso psicológico laboral o Mobbing
Authors: Calderón Nicole Chimpen , Quispe Merly Mercado , Beltrán Ponce Rosa Luz
Published: January 2022

En el Perú, no existe regulación normativa que sancione el acoso psicológico laboral. El objetivo de este estudio es determinar la necesidad de una regulación específica de la figura del acoso psicológico laboral o mobbing en el marco legal peruano. Para ello se ha analizado artículos nacionales e internacionales sobre el mobbing, término que es sinónimo de acoso psicológico, acoso laboral y acoso moral, publicados como estudio teórico en las bases de datos Redalyc, Scielo y ALICIA, entre el período de 2009 al 2019. El acoso psicológico o mobbing produce un menoscabo a la dignidad y salud mental de los trabajadores que lo sufren, por lo que, se recomienda que ésta figura jurídica se incorpore de manera específica en el Artículo 25 del TUO del Decreto Legislativo N.º 728, como una falta grave.