bluuebunny/crossref_metadata_2025 huggingface dataset:
In silico Profiling and Pharmacokinetic Modelling of Olivetol: Evaluating its Potential as a Therapeutic Agent for Diabetic Wound Healing
Authors: Shanmugasundaram Nirenjen , Jayasankar Narayanan
Published: October 2024

Background:

Diabetic wound healing poses a significant challenge due to the intricate
disruptions in cellular and molecular processes induced by hyperglycaemia, leading to delayed or
impaired tissue repair. Computational techniques offer a promising avenue for unravelling the complexities
of diabetic wound healing by elucidating the molecular mechanisms involved.

Methodology:

This study utilized in silico molecular docking and dynamics simulations to explore
the potential therapeutic effectiveness of olivetol, a phenolic compound, in the context of diabetic
wound healing. Furthermore, computational methodologies, encompassing pkCSM, Swiss ADME,
OSIRIS® property explorer, PASS online web resource, and MOLINSPIRATION® software, were
employed to forecast the pharmacokinetic properties, biological actions, and in vitro analyses, such
as MTT and scratch assays, to evaluate the therapeutic effectiveness of olivetol in wound healing.

Results and Discussion:

Our findings have revealed olivetol to be a promising candidate for targeting
multiple pathways implicated in diabetic wound healing. Its ability to modulate inflammation, oxidative
stress, extracellular matrix remodeling, angiogenesis, and cell signaling suggests a multifaceted
approach to promoting effective wound repair. Moreover, olivetol has been found to demonstrate
strong binding affinity with key MRSA target proteins, indicating its potential as an antimicrobial
agent against MRSA infections in diabetic wounds. The in vitro MTT assay demonstrated cell viability
with an IC50 value of 40.80 μM, highlighting its cytotoxicity potential. Additionally, the
scratch assay confirmed promising wound healing activity, showcasing its effectiveness in promoting
cell migration and closure.

Conclusion:

Olivetol emerges as a promising candidate for targeted interventions in non-healing diabetic
wounds, particularly due to its ability to address prolonged inflammation, a common obstacle
in diabetic wound healing.
A Theoretical Study on Derivatives of 1,2,4-Trioxane as Potential Anti-malarials and an Analysis of the Mechanism of Drug Release in the Presence Of Fe(III) Ions
Authors: Bayat Zakiyeh
Published: October 2024

Introduction:

A mechanism has been proposed for the targeted transfer of an antimalarial
drug, which involves 1, 2, and 4 trioxane (TRX) reagents. The trioxane ring is sensitive to ferrous
iron, Fe(II), and when exposed to it, it breaks down into smaller pieces, releasing the antimalarial
drug mML (a mock form of DPA1 inhibitor ML4118S).

Method:

The oxane ring is attached to a nanoparticle called adamantane, which helps facilitate the
reaction. The mechanism has been investigated using two reactants: TRX-R-mML and TRX-H-mML
complexes (R is a side chain). The researcher used the transition state theory, the Hartree-Fock level
(HF), and the ground state series 6-31G** to investigate the mechanism. The physicochemical and
geometric properties of the components involved in the reaction were measured to explain the mechanism
better.

Results:

The results indicate that the R as a side chain significantly affects the mentioned mechanism
and properties. Additionally, the results of the calculations show the stability of the complexes required
as reactants in the reaction.

Conclusion:

The TRX-mML-R complex has more strength, and polarity than TRX-mML-H, and the
energy level of the transition state of TRX-mML-R is lower than that of TRX-mML-H, indicating
faster passage of raw materials.
Application of Machine Learning Methods in Predicting Lysine-specific
Histone Demethylase 1 (LSD1) Inhibitors
Authors: Kuang Zheng-Kun , Huang Qing , Huang Lixia
Published: October 2024

Background:

Lysine-specific histone demethylase 1 (LSD1) is a well-known anti-cancer
target for drug discovery. Novel reversible inhibitors of LSD1 are desirable to be developed.

Objective:

This study aimed to build reliable predictive models to evaluate the antineoplastic efficacy
of compounds and reveal the structural foundation underlying the inhibitory activity of LSD1.

Methods:

Multiple artificial intelligence algorithms were utilized in the development of quantitative
structure-activity relationship (QSAR) models. A dataset comprising 915 compounds with welldefined
IC50 values against LSD1 was assembled for analysis. The structures of these compounds
were described by different descriptor packages. Principal component analysis (PCA) was performed
to explore the chemical space distribution of each dataset. Y-randomization test and applicability
domain (AD) analysis were deployed to validate the reliability of models.

Results:

For regression models, a consensus model was constructed by integrating the predictions of
four top-performing individual models (SVM_ECFP4, RFR_PyDescriptor, RFR_RDKIT, and
TRANSNNI), resulting in enhanced predictive performance as compared to the individual models.
The consensus model achieved a determination coefficient (r2, for the test set) value of 0.82. For
classification models, the consensus model was derived from the amalgamation of three individual
models (ASNN_RDKIT, ASNN_ECFP4, and RFR_ECFP4), and the overall prediction accuracy of
the model was 0.96 for external validation.

Conclusion:

The reliable models could be used to identify highly active LSD1 inhibitors for the
purpose of efficient virtual screening. In addition, the important molecular properties and structural
fragments derived from this work can provide guidance for the structural optimization of novel
LSD1 inhibitors.
Flemingia Strobilifera– An Updated Review on its Pharmacognostic and Pharmacological Properties
Authors: Sahu Asmit , Dubey Neha , Satapathy Trilochan , Pandey Ravindra Kumar , Shukla Shiv Shankar , Gidwani Bina
Published: October 2024

Background:

Our health care system greatly benefits from the use of old medical techniques.
In Ayurvedic medicine to improve manhood, Flemingia strobilifera (Lam.) is utilized as
an herb. The Fabaceae family, which includes Flemingia strobilifera (Palas), is widely cultivated
throughout India. There are more than forty species of Flemingia throughout the globe; out of
which 15 species of this genus are in India.

Objective:

To learn more details about this plant and various species of Flemingia, specifically the
chemical makeup of the plant, its species, and/or its elements, traditional and medical uses for the
plant. This review article also focuses on the origin, history, classification, phytochemistry, morphology,
microscopy, and pharmacological aspects.

Methods:

A detailed and extensive literature survey through research findings, review articles,
Google sources, database etc was done to explore the aspect of Flemingia species for its various
physical, chemical, pharmacological, phytochemistry and related fields.

Results:

Our findings report that several representatives of this genus have been employed as vermifuges
and remedies for fever, diarrhea, indigestion in traditional medicine. The plant's anthelmintic,
anticancer, antirheumatic, antiinflammatory, antioxidant and antihistaminic effects are
well documented. According to literature reports, the chemical constituents of this genus' are
flavonoids, glycosides, chalcones, epoxy chromenes, and pterocarpans. Rural and ethnic people
regularly use this plant to treat a range of diseases.

Conclusion:

Research on Flemingia strobilifera has a bright future thanks to its strong natural origin.
The uniqueness and usefulness of Flemingia strobilifera was obscured. In future, many more
potential of Flemingia could be investigated in combination with other herbs.
Unveiling the Various Analytical Techniques of Polyphenols for Pharmacological Activity and Nanotechnological Delivery in Wound Healing
Authors: Bhati Hemant , Bansal Keshav , Bajpai Meenakshi
Published: October 2024

Polyphenols are a diverse group of molecules known for their broad range of biological
activities, making them valuable in therapeutic applications, including wound healing.
Chronic wounds, which are often complicated by persistent infections and the rise of antibiotic
resistance, present a significant challenge in the treatment. Traditional antibiotics are becoming
less effective, necessitating the exploration of new antimicrobial agents. Polyphenols like hesperidin,
chlorogenic acid, quercetin, and curcumin are promising candidates due to their natural
antibacterial properties, offering an effective alternative to conventional antibiotics for
treating chronic wounds. However, polyphenols face challenges such as limited stability,
which can reduce their effectiveness at the wound site. Furthermore, to overcome these limitations,
polymer-based systems have been developed as carriers to stabilize polyphenols and
control their release over time, thereby enhancing their therapeutic efficacy. This article explores
the potential of polyphenols as natural antibacterial agents and highlights various nanoparticulate
systems as effective carriers for treating chronic wounds.
MG132-mediated Suppression of the Ubiquitin-proteasome Pathway Enhances the Sensitivity of Endometrial Cancer Cells to Cisplatin
Authors: Zhang Zhanhu , Ding Yiqian
Published: October 2024

Background:

Tumor cell resistance to cisplatin is a common challenge in endometrial cancer chemotherapy,
stemming from various mechanisms. Targeted therapies using proteasome inhibitors, such as MG132,
have been investigated to enhance cisplatin sensitivity, potentially offering a novel treatment approach.

Objective:

The aim of this study was to investigate the effects of MG132 on cisplatin sensitivity in the human
endometrial cancer (EC) cell line RL95-2, focusing on cell proliferation, apoptosis, and cell signaling.

Methods:

Human endometrial cancer RL95-2 cells were exposed to MG132, and cell viability was assessed in a
dose-dependent manner. The study evaluated the effect of MG132 on cisplatin-induced proliferation inhibition
and apoptosis, correlating with caspase-3 activation and reactive oxygen species (ROS) upregulation. Additionally,
we examined the inhibition of the ubiquitin-proteasome system and the expression of pro-inflammatory cytokines
IL-1β, IL-6, IL-8, and IL-13 during MG132 and cisplatin co-administration.

Results:

Human endometrial cancer RL95-2 cells were exposed to MG132, and cell viability was assessed in a
dose-dependent manner. The study evaluated the effect of MG132 on cisplatin-induced proliferation inhibition
and apoptosis, correlating with caspase-3 activation and reactive oxygen species (ROS) upregulation. Additionally,
we examined the inhibition of the ubiquitin-proteasome system and the expression of pro-inflammatory cytokines
IL-1β, IL-6, IL-8, and IL-13 during MG132 and cisplatin co-administration.

Result:

MG132 exposure significantly reduced cell viability in a dose-dependent manner. It augmented cisplatin-
induced proliferation inhibition and enhanced apoptosis, correlating with caspase-3 activation and ROS upregulation.
Molecular analysis revealed a profound inhibition of the ubiquitin-proteasome system. MG132 also
significantly increased the expression of cisplatin-induced pro-inflammatory cytokines, suggesting a transition
from chronic to acute inflammation.

Conclusion:

MG132 enhances the therapeutic efficacy of cisplatin in human EC cells by suppressing the ubiquitin-
proteasome pathway, reducing cell viability, enhancing apoptosis, and shifting the inflammatory response.
These findings highlighted the potential of MG132 as an adjuvant in endometrial cancer chemotherapy. Further
research is needed to explore detailed mechanisms and clinical applications of this combination therapy.
Relevance of Microorganisms in Causing Rain and Snow
Authors: Kaul Rimple , Devi Sunita , Sharma Megha , Chand Subhash
Published: October 2024

The Earth's climate is influenced by both natural phenomena (solar fluctuations,
oceanic patterns, volcanic eruptions, and tectonic movements) and human activities
(deforestation, CO and CO2 emissions, and desertification), all of which contribute to ongoing
climate change and the resulting global warming. However, human actions are a
major factor in exacerbating global warming and amplifying its adverse impacts worldwide.
With rising temperatures, water evaporation from water bodies and soils intensifies,
leading to heightened water scarcity, particularly in drought-prone regions. This scarcity
compounds rainfall deficits, posing significant challenges. Precipitation, essential for the
biosphere's hydrological cycle, replenishes much of the world's freshwater. It occurs when
condensed water vapor in the atmosphere falls back to Earth as rain, drizzle, sleet, graupel,
hail, or snow due to gravity. Literature highlights the indispensable role of bacterial
populations in this process, termed bio-precipitation. This phenomenon begins with bacterial
colonization on plant surfaces, with colonies subsequently dispersed into the atmosphere
by winds, triggering ice crystal formation. Through their ice nucleating property,
these microbes facilitate the growth of larger ice crystals, which eventually melt and precipitate
as rain or snow. This mechanism aids in nutrient transfer from clouds to soil or
vegetation. Pseudomonas syringae stands out as the most notable microorganism exhibiting
this ice-nucleation property, serving as the primary source of ice nucleators driving
bio-precipitation. Despite limited literature on "rain and snow-causing microorganisms,"
this review comprehensively explores the conceptual background of bio-precipitation, the
involved bioprocesses, and the critical role of bacteria like P. syringae, offering insights
into future research directions and patent innovations.
Formulation Optimization and Evaluation of Patented Solid Lipid Nanoparticles of Ambrisentan for Pulmonary Arterial Hypertension
Authors: Shewale Harshada , Kanugo Abhishek
Published: October 2024

Background:

Ambrisentan is a new endothelin receptor antagonist extensively used to
manage pulmonary or pulmonary arterial hypertension.

Objective:

The therapeutic efficacy of Ambrisentan is limited due to its reduced solubility, higher
log P (3.4), and thus less bioavailability. The recent investigation was concentrated on the improvement
of solubility, and bioavailability of Ambrisentan for the therapy of hypertension via solid lipid
nanoparticles (SLN) administered orally.

Methods:

XRD evaluated the compatibility of Ambrisentan with lipids with FTIR, DSC, and crystalline
nature. The SLN was developed by High-pressure homogenization method. The Glyceryl
monostearate and Tween 80 indicated the highest solubility, hence selected. The optimization was
performed with Box-Behnken Design considering the concentration of GMS (X1), Tween 80 (X2),
stirring speed (X3) as independent factors and particle size (Y1), entrapment efficiency (Y2) as dependent
factors. The Patents on the SLN are Indian 202321053691, U.S. Patent, 10,973,798B2, U.S.
Patent 10,251,960B2, U.S. Patent 2021/0069121A1 and U.S. Patent 2022/0151945A1.

Results:

The optimized batch F1 showed particle size (130 nm), ZP (-18.9 mV), and entrapment efficiency
(85.73 %). The dual release pattern (prompt and sustained) was achieved with the SLNloaded
Ambrisentan for about 24 hours. The lyophilized sample was subjected to SEM, which also
revealed a spherical shape of a colloidal dispersion with a particle size of 126 nm. Hence, the F1
batch is highly recommended for solid oral delivery and also for the pilot-plant scale-up.

Conclusion:

A marked improvement in the solubility and dissolution of Ambrisentan was attained
with the SLN. Moreover, the sustained delivery via the oral route enabled the patient's comfort,
compliance, and therapeutic efficacy.
Hypoxia-reoxygenation Extends the Lifespan of Caenorhabditis elegans via SKN-1- and DAF-16A-Dependent Stress Hormesis
Authors: Siswanto Ferbian Milas , Handayani Maria Dara Novi , Firmasyah Rita Dewi , Manalu Jojor Lamsihar , Pramono Adriyan
Published: October 2024

Aims:

To study the role of hypoxia-reoxygenation and anoxia-starvation on the lifespan
of C. elegans and elucidate the mechanism at molecular levels.

Background:

Increasing evidence indicates that reactive oxygen species (ROS) act as signaling
molecules that promote health. Hormesis occurs when a moderate stress level induces a beneficial
adaptive response, protecting organisms against subsequent exposure to severe stress. Caenorhabditis
elegans is a widely used model organism to study aging and displays a broad hormetic ability
to couple with stress. To date, only few methods are available to induce stress hormesis in C. elegans.

Objectives:

The objectives of this study were to explore the effects of hypoxia-reoxygenation and
anoxia-starvation on the lifespan of C. elegans, exploring the involvement of ROS and oxidative
stress-related pathways, and examining the hormetic property of H/R.

Methods:

The C. elegans were cultured in hypoxic conditions (1% O2) with OP50 bacteria for 24
h followed by reoxygenation (20% O2) (H/R) or in anoxic conditions (0% O2; 100% N2) without
OP50 bacteria for 24 h followed by reoxygenation (20% O2) and food supplementation (A/S). Survivals
were plotted and estimated for probability with Kaplan-Meier analysis.

Results:

The H/R extended the lifespan of C. elegans, and H/R-pretreated worms showed improved
resistance toward A/S compared to naïve worms. The C. elegans SKN-1 and DAF-16 are
important oxidative stress response factors homologous to mammalian Nrf2 and FOXO3, respectively.
Mutations in SKN-1 and DAF-16 blocked H/R-induced life extension. Next, H/R treatment
in C. elegans activated both SKN-1 and DAF-16, as indicated by the upregulation of putative target
genes of SKN-1 (gcs-1 and gss-1) and DAF-16 (sod-3). Moreover, pre-treatment with antioxidants
(N-acetylcysteine, chlorogenic acid, and sulforaphane) reduced ROS levels and diminished
the lifespan extension effect of H/R, indicating their dependency on ROS.

Conclusion:

These results provide evidence that H/R is beneficial for lifespan and stress resistance
by activating the adaptive cellular response pathway (SKN-1 and DAF-16A) toward oxidative
stress.
New Therapeutic Rargets for Cynodon Dactylon in Atherosclerosis: Attenuation of TMAO Generation and Down-regulation of TLR-4 in Rats
Authors: Pashaie Belal , Hobbenaghi Rahim , Malekinejad Hassan
Published: October 2024

Purpose:

Atherosclerosis (AS) is a chronic disease with worldwide incidence. The current
study was conducted to highlight the molecular pathogenesis of AS and equal effectiveness of cynodon
dactylon’s ethanolic extract (CDE) on the AS-induced injuries.

Methods:

Atherosclerosis was induced experimentally in healthy male rats with a hypercholesterolemic
diet (HCD) for 24 weeks. The HCD-received animals were either treated with normal saline
or various doses of CDE and/or atorvastatin. After 24 weeks of the treatment period, the effects of
HCD on lipid profile, oxidative/nitrosative stress status, inflammatory enzymes (LDH, ALP and CKMB)
activities, trimethylamine oxide (TMAO) concentration in serum along with the expression of
TLR-4 (qPCR) and CD31 (Immunohistochemistry) in coronary and aorta were analyzed

Results:

CDE was able to reduce the HCD-enhanced cholesterol and triglycerides. The HCDelevated
activities of LDH, ALP and CK-MB were declined by CDE. The antioxidant potency of
CDE was comparable with atorvastatin on HCD-induced oxidative/nitrosative stress. The serum
concentration of TMAO was lowered (1.7-fold) by CDE in a dose-dependent manner, while CD31
expression in the endothelial of coronary arterials and aorta in CDE and atorvastatin-received animals
was remarkably increased. The up-regulated expression of TLR-4 (2.5-fold) at mRNA level
was regulated significantly (p < 0.05) and returned to normal level by CDE treatment.

Conclusion:

Results of the current study indicate that the up-regulation of TLR-4 as a main inflammatory
gene and elevation of TMAO are involved in the pathophysiology of AS. Moreover, the protective
effects of CDE on AS may be attributed to its anti-inflammatory and hypolipidemic properties.
KONFLIK PALESTINA-ISRAEL DALAM PERSPEKTIF TEORI RUANG PUBLIK HABERMAS: RENDAHNYA DEMOKRASI KOMUNIKASI PUBLIK PADA PLATFORM “X”
Authors: Chatlina Chiara Dewi
Published: October 2024

Memanasnya konflik Palestina-Israel turut membuat pengguna platform X turut serta memberikan pendapatnya atas situasi yang sedang terjadi. Dimana, platform X  menjadi ruang yang cukup cepat dalam penyebaran informasi. Penelitian ini bertujuan untuk menganalisis komunikasi publik terkait konflik Palestina-Israel dengan merujuk pada teori ruang publik Habermas, terutama dalam konteks platform "X". Peneliti mengkaji dan menganalisis bagaimana demokrasi komunikasi atau kebebasan berpendapat di platform X mengenai konflik Palestina-Israel dengan cara melakukan pendekatan studi kasus menggunakan metode penelitian kualitatif deskriptif dengan teknik pengumpulan data kajian literatur dan observasi melalui platform X. Penelitian ini dapat menyimpulkan Platform X banyak digunakan dalam aksi menyuarakan pendapat kebenaran dalam konflik Palestina dan Israel konflik yang belakangan ini sedang memanas tidak hanya dimanfaatkan oleh individu tetapi platform X juga digunakan oleh institusi-institusi seperti media massa. Meskipun, ada kebebasan berpendapat untuk menyuarakan kebenaran dari konflik yang terjadi di Palestina dan Israel tetapi platform X membatasi konten konflik Palestina dan Israel.
TITI MENTAWAI: SANGGAHAN TERHADAP TATO MENTAWAI TERTUA DI DUNIA (TITI MENTAWAI: REFUTATION OF THE OLDEST MENTAWAI TATTOOS IN THE WORLD)
Authors: Tulius Juniator
Published: October 2024

Tato tradisional adalah salah satu tradisi prasejarah yang tidak memiliki catatan yang dapat ditelusuri kapan diciptakannya. Tato Mentawai adalah salah satunya. Namun, ada gagasan yang  menyatakan bahwa tato Mentawai tertua di dunia. Asumsi ini menjadi perdebatan di dunia akademik dan tersebar di media-media digital. Sebahagian orang meyakininya asumsi itu sebagai sebuah kebenaran. Bahkan asumsi ini dijadikan sebagai acuan yang sahih dalam membuat sebuah kebijakan publik di Mentawai. Argumen ini telah menuai kontroversi di masyarakat Mentawai. Setelah mengulas sumber-sumber ilmiah yang mendasari munculnya asumsi tato Mentawai tertua di dunia fakta-fakta berbeda ditemukan tentang tato tradisional Mentawai. Berdasarkan fakta-fakta itu disimpulkan adalah bahwa tato traditional Mentawai sebagai yang tertua di dunia tidaklah berdasar. (Traditional tattoos are perceived as a prehistoric tradition because they have no traceable records of when they were invented. Mentawai tattoos are one of them. Nonetheless, an assumption has been made to declare that the Mentawai tattoo is the oldest in the world. This assumption has been debated in academic world and spreaded through digital media. This argument has also sparked controversy in Mentawai society. Most of people believe that this assumption is a truth. Even, this assumption has been used as a valid reference in making particular public policy in Mentawai. After reviewing scientific sources of which the assumption of the oldest Mentawai tattoos in the world is made, different facts were found about traditional Mentawai tattoos. Based on these facts, it can be concluded that traditional Mentawai tattoos as the oldest in the world are unfounded).
SHORT TERM RENTAL ACCOMMODATION (STRA) AND HOME SHARING: DIFFERENT TERMINOLOGIES TO ADDRESS LEGAL REQUIREMENT OF PLANNING PERMISSION
Authors: Chua Abdullah Nuraisyah , Ramly Ramzyzan
Published: October 2024

One of the debates on permissibility of short-term residential accommodation (STRA) is whether the nature of use of the building has significantly changed, with the operation of such business in the building.  This led to the issue of whether planning permission is needed as this is a requirement in event of ‘material change of use’ of building. A home may be built as a one-family dwelling, but when it is converted to STRA use, it may be argued that it loses that character and contributes to unauthorized changes in neighbourhood character by intensifying the use both in terms of the number of people who typically use the property at any given time and by the negative impacts associated with frequent turnover. Basically, the main idea of planning permission is to ensure that there are no irregularities emerging from land use and development by individuals such as traffic jams, pollution, nuisance problems, loss of value or even amenities, floods or effects on the neighbourhood and ensures that the new development is suitable for occupation. This article suggests that one possible way to address the ‘change of character’ issue is by differentiating the types of short-term accommodation businesses based on the number of permitted bedrooms, guests, owner occupancy, number of bedrooms, location, and yearly maximum day-cap.
POLICY DRIVERS OF CHINA'S INTEGRATED ENERGY SERVICES: A CURRENT STATUS REVIEW
Authors: Xiangyu Xu , Zainordin Nazatul Syadia , Sharaai Amir Hamzah , Nik Ab Rahim Nik Nor Rahimah
Published: October 2024

Conventional energy production and consumption patterns seriously restrict global sustainable development. In the energy transformation process, integrated energy services play a key role in integrating clean energy and renewing energy consumption patterns. The European Union, the United States, and Japan are leading in developing policy frameworks and integrating integrated energy services. This paper compares and analyzes how the European Union, the United States, Japan, and China respond to the challenges of energy transformation through different energy policy systems. The energy policy systems of the European Union, the United States, and Japan are discussed for reference by China. The review reveals that (1) assigning tasks based on the energy transformation strength of each region is conducive to accelerating the speed of carbon emission reduction in each region; (2) continuous government support and targeted incentives are conducive to attracting market capital, thereby stimulating the advancement of energy technology; and (3) formulating energy efficiency standards for basic equipment can lay a good foundation for energy transformation.
THE RELATIONSHIP BETWEEN TOURIST EXPERIENCE, PLACE ATTACHMENT, AND POST-VISIT INTENTIONS: AN APPLICATION OF S-O-R PARADIGM IN THE CONTEXT OF HANGZHOU, CHINA
Authors: Fan Bai , Isa Mohd Ismail , Mohamed Badaruddin
Published: October 2024

A key challenge facing destination practitioners and policymakers is to sustain a competitive advantage and to ensure its destination’s success and prosperity under the impact of globalisation. Evidence suggests that the tourist experience can enhance tourists’ attachment and post-visit intention, which is an essential concept in travel and tourism study, as well as destination positioning. Still, there are limitations in the research concerning the relationship between these three factors.  This study investigates the mediating effect of place attachment on the relationship between tourist experience and post-visit intention using Stimulus–Organism–Response (S-O-R) paradigm. The data were gathered from 213 respondents among the West Lake Heritage Site users in Hangzhou, China, using the self-administered questionnaires. According to statistical findings, tourist experience influences post-visit intention both directly and indirectly through the mediating role of place attachment. Drawing from these findings, practical information on design, marketing, and experiences for tourism destinations is offered.
EXPLORING THE RELATIONSHIP BETWEEN PLACE ATTACHMENT AND YOUTH’S INVOLVEMENT IN RICE FIELD ACTIVITIES
Authors: Samsudin Puteri Yuliana , Mohd Arshard Wan Nur Rukiah
Published: October 2024

Youth’s experience, knowledge and values in relation to rice field activities play an important role in motivating the youth to get involved in these activities. However, there is a lack of research that focuses on the relationship between place attachment and activity involvement. The aim of this paper is to explore the relationship between place attachment and rural youth’s involvement in rice field activities. Three homestays in Kedah were selected as case studies and quantitative (302 questionnaires) approaches were applied to achieve the objective. The questionnaire survey was conducted among youth aged 20 - 34 years old. Major findings in this study include a positive relationship between place attachment and youth activity involvement. Youth who have knowledge, experience, and values in relation to rice field activities are inclined to be involved in homestay activities. The findings of this study contribute to the theories regarding youth activity involvement and place attachment. It is suggested that practitioners in built environment, tourism planning and landscape planning as well as parents should help to encourage the youth to get involved in rice field activities in homestay programmes and in their daily lives.
APPLICATION OF JOINT TENANCY ON REAL PROPERTY AND ITS IMPACT UNDER THE LAW OF SUCCESSION IN MALAYSIA
Authors: Arshad Azhani , Mohd Yusoff Rahmawati , Mat Ali Syuhaeda Aeni , Halim Akmal Hidayah , Adnan Nur Akmal
Published: October 2024

Joint ownership refers to property owned by two or more persons. Two significant forms of joint ownership in real estate exist joint tenancy and tenancy-in-common. Under common law, joint tenancy is applied as a mechanism for administering an estate, which takes effect after the joint owner's or joint tenant's death. The National Land Code (Act 828) recognises only tenancy-in-common tenancy rather than joint tenancy. Hence, this study proposes a regulatory framework and a suitable mechanism for the land conveyance process in the application of joint tenancy. This study is based on qualitative research and analysis of primary and secondary materials. For a comparative analysis, the study explores the law and practice of joint tenancy in Singapore and Australia for the dual legal and Torren systems. It is predicted that the joint tenancy application would give the proprietor more options in planning the management of his property and rightly give the surviving joint tenant full enjoyment of the property.
EXPLORING ISSUES AND ENHANCING SUSTAINABILITY: AFFORDABLE HOUSING DYNAMICS IN MALAYSIA
Authors: Ramli Nur Aqlima , Zainol Nurul Nadiah , Sukereman Anis Syazwani , Ishak Nurul Arafah
Published: October 2024

This study delves into the issues of affordable housing and elements influencing the sustainability of affordable housing, with a specific focus on the Malaysian context. The primary objective is to identify the issues associated with affordable housing in Malaysia, as well as to determine the elements crucial for enhancing sustainability in the housing sector. A quantitative method using a questionnaire survey was conducted involving three groups of respondents: building designers, facility managers, and GBI facilitators. The research employed the Kruskal Wallis statistical analysis method and Importance Index Calculation as the key methodologies. Two significant findings emerged from the study. Firstly, the issues related to ‘location and accessibility’ and ‘financing challenges’ were identified as critically important, shedding light on the obstacles faced in these domains. Secondly, the elements of ‘adaptability and upgradability’ and ‘location and accessibility’ were highlighted as pivotal contributors to the sustainability of affordable housing in Malaysia. These findings provided valuable insights for policymakers, urban planners, and stakeholders in addressing key issues and promoting sustainable practices in the realm of affordable housing.
COVID-19’S IMPACT ON FOOD STALL WORKERS: NIGHT MARKETS’ RESILIENCE IN PENANG, MALAYSIA
Authors: Lm Lim Lay , Tilaki Mohammad Javad Maghsoodi , Abdul Rahim Asyirah , Marzbali Massoomeh Hedayati
Published: October 2024

The COVID-19 pandemic has left an enduring mark on Southeast Asia, with lasting repercussions on financial markets, employment, and gender equality in the workplace. Various activities were halted in order to curb the virus’s spread, which dealt a severe blow to Malaysia’s thriving economy. The informal sector, a cornerstone of the Asia-Pacific service industry, felt these effects acutely, as it heavily relies on informal workers. Given that more than three quarters of Malaysia’s service sector comprises informal workers, the country’s economic recovery is now significantly reliant on this workforce. Considering the contribution of the informal sector to Malaysia’s food market, this study aims to explore the impact of social shocks and economic crises on the resilience of informal workers during the COVID-19 pandemic. Using a multistage probability sampling method, the study employed a questionnaire survey involving Penang’s food stalls in night markets. Findings reveal significant variations in workers’ lifestyles, attitudes, and family dynamics. Gender-related factors also exert a substantial influence on their behavior, attitudes, and engagement levels. While many studies have examined night markets as tourism spots in terms of how to increase sales or attract visitors, this study is among the first to focus on the vendors themselves, exploring the impact of COVID-19 on food stalls as an unseen vulnerable community.
IMPROVING ROAD SAFETY AT ACCIDENT-PRONE AREAS: A COMPARISON BETWEEN GLOW-IN-THE-DARK AND CONVENTIONAL ROAD MARKING
Authors: Semadi Hadi Farhan , Ayob Mohd Fairullazi
Published: October 2024

Driving at night is challenging due to poor vision, poor road visual guidance, and the need to encounter bright light sources. Factors like lack of street lighting, fading, and lack of reflectivity by road studs and retro-reflective materials affect road users' vision at night. Commentators have pointed out there is a critical demand to improve road safety in preventing road accidents and hazards that caused by the poor visibility of road markings and inadequacy lighting. Although road safety management has been given an important focus by the Ministry of Transportation Malaysia to achieve 50% reduction of road accidents by 2030, there is a critical demand to improve the present road markings method to overcome the issues of poor visibility or unclear road markings and inadequacy lighting that may trigger potential hazards to road users at night, with a new innovative road marking technology. Therefore, this paper is prepared with the objective to present the outcome of comparative study between the present conventional road markings and the newly innovative technology of glow-in-the-dark method with specific reference to the road safety management in Malaysia. This study employed a questionnaire survey to interview fifty-one (51) respondents that have experience of driving at night, with the objectives to get their opinions on present condition of road markings in Malaysia, and how the newly innovative technology glow-in-the-dark can improve road safety in Malaysia. The study outcome revealed that the glow-in-the-dark is deemed appropriate to enhance the visibility during low-light conditions as compared to the present conventional road markings. Although the initial cost is higher, the economic advantages of glow-in-the-dark in reducing the streetlight usage, lower electrical costs, and substantially extended lifespan have made this newly innovative road marking outweighed the downsides and economically wise choice to revolutionize road safety management practice at the accident-prone areas in Malaysia for achieving the SDG 3: Good Health and Well-being.
THE APPLICATION OF CHOICE MODELLING FOR A SANITARY LANDFILL IN KOTA BHARU, KELANTAN, MALAYSIA
Authors: Nik Ab Rahim Nik Nor Rahimah , Othman Jamal , Yacob Mohd Rusli
Published: October 2024

Environmental impacts from poor landfilling practices have long been a concern in Kota Bharu, a densely populated city in Peninsular Malaysia. Addressing this issue requires a sustainable disposal solution, such as a sanitary landfill. However, such a project can fail without understanding household demand. This study examined households' willingness to pay for a sanitary landfill using a survey-based method known as Choice Modelling. This method was employed to determine households' willingness to pay for the environmental benefits of a sanitary landfill, characterized by attributes like controlled leachate discharge, reduced bad odour, reduced disease vectors, and pleasing views. The results indicated a positive willingness to pay for each attribute, ranging from RM2.37 to RM12.08 per month. This information aids policymakers in making decisions that align with household demands, thereby minimizing opposition and enhancing project feasibility.
Current State of Community-Driven Radiological AI Deployment in Medical Imaging
Authors: Gupta Vikash , Erdal Barbaros , Ramirez Carolina , Floca Ralf , Genereaux Bradley , Bryson Sidney , Bridge Christopher , Kleesiek Jens , Nensa Felix , Braren Rickmer , Younis Khaled , Penzkofer Tobias , Bucher Andreas Michael , Qin Ming Melvin , Bae Gigon , Lee Hyeonhoon , Cardoso M Jorge , Ourselin Sebastien , Kerfoot Eric , Choudhury Rahul , White Richard D , Cook Tessa , Bericat David , Lungren Matthew , Haukioja Risto , Shuaib Haris
Published: October 2024

Artificial intelligence (AI) has become commonplace in solving routine everyday tasks. Because of the exponential growth in medical imaging data volume and complexity, the workload on radiologists is steadily increasing. AI has been shown to improve efficiency in medical image generation, processing, and interpretation, and various such AI models have been developed across research laboratories worldwide. However, very few of these, if any, find their way into routine clinical use, a discrepancy that reflects the divide between AI research and successful AI translation. The goal of this paper is to give an overview of the intersection of AI and medical imaging landscapes. We also want to inform the readers about the importance of using standards in their radiology workflow and the challenges associated with deploying AI models in the clinical workflow. The main focus of this paper is to examine the existing condition of radiology workflow and identify the challenges hindering the implementation of AI in hospital settings. This report reflects extensive weekly discussions and practical problem-solving expertise accumulated over multiple years by industry experts, imaging informatics professionals, research scientists, and clinicians. To gain a deeper understanding of the requirements for deploying AI models, we introduce a taxonomy of AI use cases, supplemented by real-world instances of AI model integration within hospitals. We will also explain how the need for AI integration in radiology can be addressed using the Medical Open Network for AI (MONAI). MONAI is an open-source consortium for providing reproducible deep learning solutions and integration tools for radiology practice in hospitals.
Oxidative stress markers and prediction of severity by a machine learning approach in hospitalized patients with COVID-19 and severe lung disease: a feasibility study (Preprint)
Authors: RASPADO OLIVIER , BRACK michel , BRACK Olivier , VIVANCOS Mélanie , ESPARCIEUX Aurélie , CART-TANNEUR Emmanuelle , AOUIFI Abdellah
Published: October 2024

BACKGROUND

Oxidative Stress (OS) is an imbalance between the production of free radicals and the body's ability to neutralize them, leading to damages of cells, proteins and deoxyribonucleic.

OBJECTIVE

To identify the relevant biomarkers of OS which could be associated to severity of hospitalized patients and to identify a possible correlation between OS biomarkers and clinical status of hospitalized COVID-19 patients with severe lung disease at hospital admission.

METHODS

All adult patients hospitalized with COVID-19 at the Infirmerie Protestante (Lyon, France) from 9th February 2022 to 18th May 2022 were included, regardless of the care service. The final sample consisted in 28 patients. Ten biomarkers were collected per patient (Zinc (Zn), Copper (Cu), Cu/Zn, Selenium, Uric acid, CRplus, Oxidized LDL, Glutathione peroxidase, Glutathione reductase and Thiols), as well as demographic variables and comorbidities. A support vector machine (SVM) model was used to predict the severity grade per patient, based on the collected data as training set.

RESULTS

: Three biomarkers of OS were associated with severity; Zn, Cu/Zn and Thiols especially for grade 0 (asymptomatic) and grade 1 (mild to moderate severity). The SVM model predicted the level of severity from the biological analysis of the OS biomarkers with only 7.14% of discrepancy in the training dataset.

CONCLUSIONS

In case of COVID-19 infection, moderate to severe symptomatic patients are associated with a lowered zinc level, a lowered plasma thiol level, an increased CRPus and an increased Cu/Zn ratio among a panel of ten biomarkers of OS.
A scoping review of fear, resilience, reluctance, scepticism and anxiety towards medical AI among medical professionals and suggestions for successful implementation of AI into medical practice (Preprint)
Authors: Nora Arvai , Katonai Gellért , Mesko Bertalan
Published: October 2024

UNSTRUCTURED

Introduction: The rapid progress in the development of artificial intelligence (AI) is having a substantial impact on healthcare (HC) delivery and the doctor-patient interaction. This scoping review seeks to offer a thorough analysis of the current status of integrating AI into medical practice and the apprehensions expressed by healthcare professionals (HPs) over its application.
Methods: This scoping review utilized the PRISMA-ScR method to examine papers that investigate the apprehensions of HPs about medical AI. Following the application of inclusion and exclusion criteria, a total of 32 studies were selected for the final analysis. Our objective was to develop an attitude measure that accurately captures the unfavorable attitudes of HPs towards medical AI. We achieved this by selecting attitudes and then ranking them on a scale that represents the degree of aversion, ranging from mild skepticism to intense fear. The ultimate depiction of the scale is as follows: Skepticism, reluctance, anxiety, resistance, and fear.
Results: Three themes were identified through the process of thematic analysis. National surveys performed among HPs aim to comprehensively analyze the current emotions, worries, and attitudes regarding the integration of AI in the medical industry. Research on technostress primarily focuses on the psychological dimensions of adopting AI, examining the emotional reactions, fears, and difficulties experienced by human participants when they encounter AI-powered equipment. The high-level perspective category includes studies that take a broad and comprehensive approach to evaluating overarching themes, trends, and implications related to the integration of AI technology in HC.
Discussion: We have discovered a total of 15 concerns, which we have classified into 2 distinct groups. We have designated these two classifications as intrinsic and extrinsic. The initial group focuses on HP's inherent professional identity, encompassing their tasks and capacities. Conversely, the second group pertains to their patients and the influence of AI on patient care. Next, we examine the shared themes and made suggestions to potentially tackle the discovered problems. Ultimately, we analyze the results in relation to the attitude scale, assessing the degree to which each attitude is portrayed.
Conclusions: The solution to addressing resistance towards medical AI appears to be centered around comprehensive education, the implementation of suitable legislation, and the delineation of roles. Due to the current prominence and extensive research on regulation, we suggest that future studies should focus on education.
The Relationship of Drug Therapy Problems and Outcome Therapy in Tuberculosis Patients in Surabaya Health Center
Authors: Wijaya I Nyoman , Nathganeila Luthfia Andini , Priyandani Yuni
Published: October 2024

Background: Tuberculosis (TB) is a highly contagious disease and is difficult to eradicate in Indonesia. Indonesia ranks second in the number of TB sufferers in the world. Generally, TB patients use more than two types of drug therapy it can affect the drug therapy problems that arise and can affect the success of treatment.Objectives: This study aims to see the effect of the number of drugs used by TB patients on the number of drug therapy problems (DTP) and therapy outcomes in tuberculosis patients.Methods: This study was a cross-sectional study with purposive sampling conducted at health centers in the Surabaya area in January- June 2024. The sample inclusion criteria included pulmonary tuberculosis patients who had undergone treatment for over one month, were not less than 17, and could communicate well using a guided interview method.Results: The results showed that the number of patients who participated in the study was 110 people. Most patients used 4 types of drugs (30.0%). Most (30.0%) had two DTPs. Spearman's relationship test between the number of drugs and the number of DTPs with a p-value = 0.000 and a correlation coefficient of 0.472. Spearman's relationship test between the number of DTP and the outcome therapy with a p-value = 0.430 and a correlation coefficient of -0.076.Conclusion: From this study, it can be concluded that there is a significant relationship between the number of drugs and the number of DTPs in TB patients and there is no relationship between RTP and therapeutic outcomes in TB patients.
BERDAZIMER SODIUM IS THE PROMISING DRUG FOR THE TREATMENT OF MOLLUSCUM CONTAGIOSUM
Authors: DANDEKAR VIKRANT , KARMARKAR AMRIT
Published: October 2024

Molluscum Contagiosum (MC) is an infectious dermatosis disease caused by Molluscum Contagiosum Virus (MCV). MC is treated with mechanical, chemical, immunomodulatory, and antiviral drugs. Predominantly, immunodeficiency HIV-positive patients expressing resistance to MC lesions effectively responded to available drug molecules; therefore, there is a need to develop an effective drug molecule for the treatment of MC infection. Berdazimer topical gel, 10.3% has been developed by Novan Inc. (Ligand Pharmaceuticals) under the brand name Zelsuvmi® for treating MC infection in adult and pediatric patients. Berdazimer topical gel, 10.3% is a Nitric Oxide (NO) releasing topical gel comprising novel NO-based technology platform NITRICI™, which stores gaseous NO species on large polymers.
Actas de economía y complejidad I
Authors: Mansilla Corona Ricardo Lino
Published: October 2024

Los sistemas económicos en sus diferentes escalas: regional, nacional y mundial son ejemplos paradigmáticos de sistemas complejos. El conjunto de interacciones, con frecuencia no lineales, que se establecen entre los diferentes agentes económicos son el crisol del cual surgen las propiedades emergentes, sellos distintivos de estos sistemas. Los padres fundadores de la teoría económica lograron vislumbrarlas, sólo que no poseían las herramientas necesarias para su plena comprensión. La situación actual es diferente, de una endémica escasez de datos hemos pasado a un arrollador tsunami de cifras económicas. Las computadoras digitales se han convertido en las herramientas básicas de investigación que nos permiten indagar con una profundidad antes imposible sobre los fenómenos económicos. Esto ha permitido el uso de los conceptos, métodos y herramientas de la teoría de los sistemas complejos para un mayor conocimiento de los fenómenos económicos. Esperamos que este libro ayude al lector a adentrarse en el ámbito de la complejidad de los sistemas económicos y contribuya a la difusión de los principios de la teoría de los sistemas complejos en la docencia universitaria.