bluuebunny/crossref_metadata_2025 huggingface dataset:
Genomic Analysis Of NAD+ Synthesis Pathways Involved In Aging and Cancer
Authors: Meyers Jeremy , Castro-Portuguez Raul , Espejo Luis , Sutphin George
Published: December 2021

Cancer cells have elevated energy demands to sustain continuous growth and other malignant processes and undergo extensive metabolic reprogramming to meet these demands. One element of this reprogramming in many cancer subtypes is elevated synthesis of nicotinamide adenine dinucleotide (NAD+), a critical co-enzyme that supports energy production through both glycolysis and the TCA cycle. The kynurenine metabolic pathway is the evolutionarily conserved means by which cells produce NAD+ de novo from tryptophan. NAD+ levels drop with age, a contributing factor to many forms of age-related disease. While interventions that increase NAD+ have been shown to extend lifespan, previous work from our lab demonstrates that knockdown of several kynurenine pathway enzymes, thus decreasing de novo NAD+ production, results in increased longevity of Caenorhabditis elegans by 20-30%. To address this apparent contradiction, we propose that kynurenine pathway inhibition may produce metabolic feedback that results in upregulation of NAD+ recycling. Eukaryotic cells recycle NAD+ from nicotinamide (NAM) through one of two pathways: the Salvage pathway in mammalian cells and the Preiss-Handler pathway in C. elegans and related invertebrates species. We are using tools in C. elegans and human cell culture to examine the interaction between kynurenine/de novo NAD+ synthesis and NAD+ recycling through Salvage and Preiss-Handler. In particular, we are interested in how combining interventions between these pathways will influence activity throughout the NAD+ metabolic networks (measured via mass spectrometry), physiological phenotypes, and transcriptomic changes (via RNA sequence data) involved in aging and age-associated disease.
Plasma Biomarkers of Angiogenesis Related to Small Vessel Brain Disease in SPRINT
Authors: Pajewski Nicholas , Elahi Fanny , Ix Joachim , Nasrallah Ilya , Hinman Jason , Launer Lenore , Williamson Jeff , Wilcock Donna
Published: December 2021

Meta-analyses incorporating the Systolic Blood Pressure Intervention Trial (SPRINT) have shown a reduced incidence of dementia with blood pressure lowering. However, mechanistic explanations for this effect are lacking, apart from slowed progression of cerebral white matter lesions (WML). Here we examine possible biomarkers of angiogenesis related to small vessel brain disease including bFGF, FLT1, PLGF, TIE-2, VEGF, VEGF-C, and VEGF-D. The biomarkers were assayed in plasma at baseline and during follow-up (median follow-up = 3.8 years) in a subgroup of participants 60 to 89 years old from SPRINT (N=517). We modeled changes in each biomarker using robust linear mixed models accounting for treatment group, time since randomization, and kidney function. Participants were 69.8 ± 7.1 (standard deviation) years of age, 42.1% female, with a mean systolic blood pressure (SBP) of 138.2 ± 17.0 mm Hg. At baseline, none of the biomarkers were associated with WML lesion volume or total brain volumes adjusting for age (all p>0.05), while FLT1, PLGF, and TIE-2 were negatively associated with frontal gray matter cerebral blood flow (partial correlations of -0.11, -0.10, and -0.12 respectively, all p<0.05). For both intensive (target SBP<120 mm Hg) and standard (target SBP<140 m Hg) blood pressure control, mean levels for the majority of biomarkers increased during follow-up, with the exceptions of TIE-2 (decreased over follow-up) and VEGF-D (no change). We did not observe significant between-group differences for the change in these plasma biomarkers of angiogenesis comparing intensive to standard blood pressure treatment.
Using Threshold Regression as an Approach to Incorporate Informative Missingness in Long Life Family Study Data
Authors: Zhbannikov Ilya , Arbeev Konstantin , Bagley Olivia , Loika Yuriy , Kulminski Alexander , Ukraintseva Svetlana , Stallard Eric , Yashin Anatoliy
Published: December 2021

Genetics of aging is important since aging is a major risk factor in most diseases. Variables describing physiological state and cognitive functioning that influence morbidity and mortality risks can serve as biomarkers of aging. They change with increasing age and the ways in which these variables change can also influence these risks. Missing data due to dropout or death create problems in longitudinal studies producing biased results especially if the gap between exams is relatively long, as is the case in the Long Life Family Study (LLFS). We applied the threshold regression model to LLFS data to investigate the vitality and its rate, which are conceptualized as latent variables characterizing health and longevity, and to cope with such a problem. We performed genome-wide association study by sex and age groups to discover genetic signals on these phenotypes. We found 11 variants from the DACT2 gene, p-values < 1E-6 and variants rs12151399 (p-value = 8.43E-8, intron variant, gene AGAP1, in females), rs27958 (p-value = 8.39E-8, intron variant, gene ARHGAP26, in males) showing associations with the vitality. Olfactory receptors showed significant enrichment among the group of males over 80 years for the rate of aging phenotype. Results showed that vitality and its rate differ among sex and age groups. This work is an important step toward understanding the processes of aging linking the vitality with individual genetics using data from deceased and living individuals.
Effects of Smoking Cessation on Epigenetic Aging
Authors: Chen Brian , Wang Weiye , Rigby Nichole , Olson Randal , Sabes Steve
Published: December 2021

“Epigenetic clocks” have become widely used to assess individual rates of biological aging. However, experimental data are limited in humans to identify potential confounding factors that may influence one’s rate of epigenetic aging and multiple health outcomes. We examined multiple epigenetic aging measures among regular smokers who quit smoking for two weeks. DNA methylation markers were assessed in both whole blood and saliva at multiple time points using a customized DNA methylation microarray. Generally, no changes in epigenetic aging rates were detected in the two week observation period with the exception of pronounced decreases over time in rate of Hannum’s clock and Extrinsic Epigenetic Age Acceleration in blood DNA. In saliva DNA, decreases over time were detected in the rates of the GrimAge and DNAmPhenoAge clocks, but we saw an increase in the rate of the Skin and Blood Clock. Additional experimental studies of other common exposures may be useful to better characterize factors that may affect the observed “rate” of epigenetic aging.
Hematopoietic mosaic chromosomal alterations in the New England Centenarian Study.
Authors: Leshchyk Anastasia , Genovese Giulio , Monti Stefano , Perls Thomas , Sebastiani Paola
Published: December 2021

Mosaic chromosomal alterations (mCAs) are structural alterations that include deletions, duplications, or copy-neutral loss of heterozygosity. mCAs are reported to be associated with survival, age, cancer, and cardiovascular disease. Previous studies of mCAs in large population-based cohorts (UK Biobank, MGBB, BioBank Japan, and FinnGen) have demonstrated a steady increase of mCAs as people age. The distribution of mCAs in centenarians and their offspring is not well characterized. We applied MOsaic CHromosomal Alteration (MoChA) caller on 2298 genome-wide genotype samples of 1582 centenarians, 443 centenarians’ offspring, and 273 unrelated controls from the New England Centenarian Study (NECS). Integrating Log R ratio and B-allele frequency (BAF) intensities with genotype phase information, MoChA employs a Hidden Markov Model to detect mCA-induced deviations in allelic balance at heterozygous sites consistent with genotype phase in the DNA microarray data. We analyzed mCAs spanning over 100 k base pairs, with an estimated cell fraction less than 50%, within samples with genome-wide BAF phase concordance across phased heterozygous sites less than 0.51, and with LOD score of more than 10 for the model based on BAF and genotype phase. Our analysis showed that somatic mCAs increase with older age up to approximately 102 years, but the prevalence of the subjects with mCAs tend to decrease after that age, thus suggesting that accumulation of mCAs is less prevalent in long-lived individuals. We also used Poisson regression to show that centenarians and their offspring tend to accumulate less mCA (RR = 0.63, p=0.045) compared to the controls.
Exercise During Childhood Protects Against Cardiac Dysfunction Later in Life
Authors: Bruns Danielle , DeHoff MacKenzie , Yusifov Aykhan , Polson Sydney , Cook Ross , Schmitt Emily , Woulfe Kathleen
Published: December 2021

Cardiovascular disease continues to be a major cause of morbidity and mortality, particularly in aging populations. Exercise is amongst the most cardioprotective interventions identified to date, with early in life exercise such as during the juvenile period potentially imparting even more cardioprotective outcomes due to the plasticity of the developing heart. To test the hypothesis that juvenile exercise would impart later in life cardioprotection, we exercised juvenile male and female mice via voluntary wheel running from 3-5 weeks of age and then exposed them to cardiac stress by isoproterenol (ISO) at 4-6 and 18 months of age in adulthood and older age, respectively. We compared cardiac function and remodeling to sedentary control animals, sedentary animals who received ISO, and adult and aged mice that exercised for two weeks immediately before ISO exposure. Juvenile mice engaged in voluntarily wheel running, with male mice running 1.3 ± 0.8 km and female mice 2.8 ± 1.0 km a day. Echocardiography suggested that these juvenile animals underwent running-induced cardiac remodeling as evidenced by higher ejection fraction and stroke volume compared to sedentary controls. Exercise in the juvenile period attenuated ISO-induced cardiac hypertrophy and remodeling later in life compared to sedentary animals and those that exercised immediately before ISO administration. The mechanisms by which early versus late exercise is protective in adult and aged mice are under investigation. Further ongoing work will identify the adaptations induced by exercise in the juvenile heart that may help improve cardiac aging.
Losartan Mitigates Oxidative Stress in the Brains of Aged IL10-/- Mice
Authors: Saleh Nazaneen , Cosarderelioglu Caglar , Vajapey Ramya , Walston Jeremy , Abadir Peter M
Published: December 2021

Chronic inflammation has been linked to frailty and declined cognition in older adults. Activation of the renin-angiotensin system (RAS) through the angiotensin Type1 receptor (AT1R) has been suggested as a contributory factor that links both inflammation and aging. Here we examined the impact of 4 weeks of oral Losartan treatment on IL10-/- mice brains, a mouse model of chronic inflammation and frailty. Frontal cortex, cerebellar, and hippocampal tissue of aged (100 weeks old) male IL10-/- mice were studied. Western blot techniques were employed to quantify changes in brain AT1R, nitrotyrosine (NT) as an oxidative stress marker, and Tau proteins. Our data show that aged IL-10 mice have significantly higher levels of AT1R in the cortex tissue but not in cerebellar or hippocampal tissue compared to age and sex-matched WT mice (0.63 + 0.35 vs 1.5 + 0.54, WT vs IL10, respectively, P<0.004). When treated with LOS, brain cortical tissue of IL10 -/- mice showed significant decreases in levels of AT1R (1.5 + 0.54 vs 0.98 + 0.50, IL10 vs LOS treated IL10, respectively, P<0.04), NT (0.72 + 0.12 vs 0.42 + 0.10, IL10 vs LOS treated IL10, respectively, P<0.009), and Tau protein (1.3 + 0.31 vs 0.15 + 0.08, IL10 vs LOS treated IL10, respectively, P<0.004) as compared to control IL10-/- mice. Losartan treatment had no significant effect on hippocampal AT1R or NT levels. Our results highlight the impact of Losartan, a drug commonly prescribed for the treatment of high blood pressure, on the brain-specific angiotensin system and its downstream effects on brain oxidative stress and Tau pathology.
The relationship between physical activity intensity and volume on prospective falls in older adults
Authors: Whitten Justin , Tarabochia Dawn , MacDonald David , Barrett Rod , Carty Chris , Graham David
Published: December 2021

The benefits of Physical Activity (PA) for older adults have been well documented relative to several physiological and neuromuscular factors, but the direct relationship of PA to fall incidence is unclear. In particular, the influence of the intensity and volume of habitual activities of daily living is poorly understood. The purpose of this study was to evaluate the influence of general PA intensity and overall volume on prospective falls in older adults. The PA of 134 participants was recorded using accelerometers (ActiGraph-GT3X+) over 7 consecutive days. Intensity was classified as light, moderate and vigorous by step frequency. The activity of all participants was graded as sedentary to low intensity, no participant exhibited activity in the vigorous category. During the following 12-months, participants maintained a daily falls diary and completed monthly phone calls to monitor fall incidence. Responses were used to categorize participants as fallers or non-fallers. Eighteen participants experienced one or more falls during the 12-month period. There was no statistical difference between fallers and non-fallers in either total step count or the percentage of time spent in sedentary or light PA. While previous reports suggest that many falls occur during light PA, our results do not suggest that greater volumes of low intensity activities alone results in greater fall incidence. However, we suggest this result may be influenced by physical stimuli participants received within the larger overall study design including a session of repeated exposure to forward loss of balance.
Successful Exogenous Expression of ATP8, a Mitochondrial Encoded Protein, From the Nucleus In Vivo.
Authors: Begelman David , Dixit Bhavna , Lewis Caitlin , Watson Mark , Brand Martin , Boominathan Amutha
Published: December 2021

Replicative errors, inefficient repair, and proximity to reactive oxygen species production sites make the mitochondrial DNA (mtDNA) susceptible to damage with time. mtDNA mutations accumulate with age and accompany a progressive decline in organelle function. We lack molecular biology tools to manipulate mtDNA, thus we explore the possibility in vivo of utilizing allotopic expression, or the re-engineering mitochondrial genes and expressing them from the nucleus, as an approach to rescue defects arising from mtDNA mutations. This study uses a mouse model with a mutation in the mitochondrial ATP8 gene that encodes a protein subunit of the ATP synthase. We generated a transgenic mouse with an epitope-tagged recoded and mitochondrial-targeted ATP8 gene expressed from the nucleus. Our results show that the allotopically expressed ATP8 protein in the transgenic mice is robustly expressed across all tested tissues, successfully transported into the mitochondria, and incorporated into ATP synthase. We are currently evaluating if allotopic expression of ATP8 will functionally rescue the behavioral and bioenergetic defects in ATP8 mutant mice. Translating allotopic expression technology into a mammal and demonstrating systemic functional rescue will lend credence to utilizing allotopic expression as a gene therapy in humans to repair physiological consequences of mtDNA defects that may accumulate with age.
Predictors of Racial Differences in Depression and Affect among Older adult, Long-term Cancer Survivors
Authors: Deimling Gary , Burnham Dyanna , Beck Gabrielle
Published: December 2021

Research has long documented the psycho-social sequelae experienced by those who have been treated for and survived cancer. Depression, affect and other indicators of mood state have been an important focus of that research However, there is little research on racial differences in depression and affect outcomes or the specific cancer and age-related factors that predict them. The research to be presented is based on a 10 year, six wave NCI funded study of 471 older adult (age 60+), long-term cancer survivors randomly selected from the tumor registry of a comprehensive cancer treatment center. Key outcome measures were depression (CES-D) scale) and both positive and negative affect (PANAS). Covariance analyses and nested OLS Regression were used to identify Black-white differences these outcomes and the relative importance of both cancer and non-cancer predictors. Blacks reported lower levels of depression and negative affect when compared to whites. In a separate regression analysis of the black sub-sample, continuing cancer-related symptoms were by far the strongest predictors (beta =.16) of negative affect. In the white sub-sample, while cancer-related symptoms continued to be a significant predictor (beta=.16), non-cancer symptoms were substantially more important (beta=. 22). These results will hopefully help practitioners to have a better understanding of the nuanced racialized experiences and mental health among cancer survivors, and how these may impact after-care for older adult cancer survivors.
Who Volunteers? Results from a Regular Cognitive Monitoring Study
Authors: Veal Britney , Sadeq Nasreen , Atkinson Taylor , Andel Ross
Published: December 2021

Previous research indicates volunteering promotes well-being of individuals and communities. Volunteering in later-life may buffer some of the negative health effects experienced during retirement, facilitating opportunities for older adults to engage in meaningful activities and stay active. The current study examined characteristics of older adults who volunteered outside of participation in a regular cognitive monitoring study. All 124 members (M= 76.87, SD= 7.47; 80 volunteers, 44 non-volunteers) of a regular cognitive monitoring study, requiring completion of a 15-minute cognitive online test once a month, with complete data on personal characteristics, volunteer activities, as well as study adherence and dropout rates were included. ANCOVA and logistic regression analyses adjusted for sociodemographic characteristics were used to assess differences between volunteers and non-volunteers. Results indicated that volunteers were less educated (p<.05), and slightly more likely to be younger and women compared to non-volunteers. There were no differences in cognitive performance (ps>.05). Volunteers had lower scores for neuroticism (p=.02) and were marginally higher agreeable and extraverted (ps<.09). Volunteers needed more reminders to complete the monthly test (ps<.01) but had lower dropout rates (p=.001). The most frequent type of volunteer activity reported was religious. Volunteers were motivated mainly by altruism, although most reported multiple reasons such as building social relationships and feeling important. Findings provide information about characteristics that can help identify older adults who are likely to volunteer. Results regarding study adherence may have implications for promoting recruitment and retention among older adult volunteers.
Factors that Influence the Emotional Impact of Memory Problems in Older Adults: A Mixed-Methods Study
Authors: Bratlee-Whitaker Emily , Hill Nikki , Mogle Jacqueline , Wion Rachel , Madrigal Caroline , Bhargava Sakshi
Published: December 2021

Older adults’ experiences with memory problems may be an important indicator of current and future well-being; however, these experiences and their impacts are poorly characterized, particularly in those with co-occurring affective symptoms. The purpose of this mixed-methods study was to examine how the experience of memory problems influences emotional well-being in older adults without dementia, and whether this differs based on cognitive status and current depressive symptoms or anxiety symptoms. A convergent parallel mixed methods design was used in which quantitative and qualitative data were collected simultaneously, analyzed separately, and then integrated to determine how participants’ experiences differed. Community-dwelling older adults (n=49, Mage = 74.5, 63% female) without severe cognitive impairment completed study questionnaires and two individual, semi-structured interviews. Five themes were identified that described the influence of memory problems on emotional well-being: Evoking Emotions, Fearing Future, Undermining Self, Normalizing Problems, and Adjusting Thinking. The extent to which memory problems impacted emotional well-being depended on multiple factors including current affective symptoms (primarily anxiety), characteristics of the experience (such as judgments of its importance), as well as personal experience with dementia. Notably, there were no thematic differences in the emotional impact of memory problems between older adults with normal cognition and those with evidence of mild cognitive impairment. Our findings suggest that thorough assessment of reports of memory problems, regardless of cognitive testing outcomes, should consider co-occurring subsyndromal affective disorders as well as older adults’ evaluations of how memory problems influence their daily lives and well-being.
Manifestations of Aging in Virtual Reality Implementation of Rod and Frame Test
Authors: Adamski Michal , Latka Miroslaw , Latka Anna , West Bruce
Published: December 2021

Senior adults’ reliance on the visual frame of reference for spatial orientation is a manifestation of an age-related shift in cognitive style from field independence to field dependence. We implemented a virtual reality rod and frame test (VR-RFT) to assess visual field dependence (VFD) in n=39 young adults (20-30 years old) and n=43 seniors (60 years old and above). The subjects were asked to determine subjective visual vertical (SVV) for 19 angles of frame tilt (running from -45 degrees to 45 degrees in steps of 5 degrees). The strong VFD of seniors was manifested not only by the increased error in the determination of SVV (SVVE) but also in its distribution. For small and large frame tilt angles, seniors’ SVVE skewness and kurtosis were greater than those of young adults. The SVVE median dependence on frame tilt may be accounted for with a phenomenological model whose two parameters describe the strengths of primary (P) and secondary (S) visual attractors which subjects use to infer SVV: the edges of the frame and its imaginary diagonals. For young adults, these parameters were: PY=14.91 and SY=12.51. For seniors, we observed an over 50% increase in the strength of the primary attractor PS=26.31 while the strength of the secondary one was only weakly affected by aging: SS=13.74. We demonstrate that the asymmetry between the strength of attractors significantly contributes to SVVE made by seniors at large frame tilts. We hypothesize that a variant VR-RFT may be used in rehabilitation to reduce excessive VFD.
Subclinical Cardiac Dysfunction and Cognitive Function: A Systematic Review
Authors: Maalouf Mario , Farah Raymond , Bahous Sola , Matli Kamal , Hazzouri Adina Zeki Al , Costanian Christy
Published: December 2021

Background: Cardiovascular disease, and more recently, subclinical cardiac dysfunction have both been implicated as important risk factors for cognitive decline. Several measures have been used to detect subclinical cardiac dysfunction, with global longitudinal strain (GLS) emerging as an important and more sensitive indicator than traditional measures. Yet, the association of GLS with cognitive function remains relatively unexplored. Objective: The aim of this review is to systematically summarize the literature exploring the association between GLS and cognitive function. Methods: We conducted a systematic review of the literature following PRISMA guidelines using the following databases: PubMed, OVID Medline, Embase, Web of Science, and CINAHL. Inclusion criteria were observational studies published in English, measuring GLS and assessing cognitive function through neuropsychiatric tests or brain imaging. Quality assessment was done using the Newcastle Ottawa Scale. Results: The initial search revealed 394 studies, of which three met inclusion criteria and were included for final review. The three studies included were cross-sectional and of high quality. They all reported that lower GLS scores were associated? with worse cognitive function and more brain abnormalities in both bivariate and multivariable analysis. Conclusion: Subclinical cardiac dysfunction, identified by GLS, was associated with worse cognitive function and presence of cerebral abnormality on brain imaging. The underlying mechanism could be attributed to dysfunctional autoregulatory and microvascular processes occurring in the brain vasculature. Further longitudinal studies are needed to better delineate the relationship between GLS and cognitive function.
Interactive effects of age and inflammation on change in ecologically-assessed cognitive functioning
Authors: Engeland Christopher , Knight Erik , Sliwinski Martin , Graham-Engeland Jennifer
Published: December 2021

Inflammation has been implicated as a precursor to steeper declines in age-associated cognitive decline. Here we investigated biomarkers of peripheral inflammation [basal cytokines, stimulated cytokines (ex vivo), C-reactive protein (CRP)] as moderators of age-related changes in cognitive functioning. As part of the Effects of Stress on Cognitive Aging, Physiology, and Emotion (ESCAPE) study, participants (N = 233; 65% female; 63% Black, 25% Hispanic; 25-65 years of age) completed up to four instances of ambulatory cognitive testing per day across two weeks, over three waves of annual assessments. After each 2-week ecological momentary assessment (EMA) burst, blood was collected and assayed for inflammatory biomarkers. Performance on spatial working memory (mean Euclidean distance errors), processing speed (mean symbol search reaction time), and working memory (n-back test accuracy) tasks were averaged across all instances within an EMA burst. CRP and age interactively predicted change in spatial working memory (B = 0.003, [0.000, 0.005], t(133.60) = 2.350, p = 0.020) such that higher CRP at older ages (~60 years) was associated with a loss of the expected practice effects across waves; at younger ages, CRP did not relate to change in spatial working memory. In a similar fashion, basal (B = -0.002, [-0.004, -0.000], t(103.26) = -2.399, p = 0.018) and stimulated cytokine levels (B = -0.002, [-0.004, -0.000], t(126.65) = -2.183, p = 0.031) interacted with age to predict change in processing speed across waves. These results indicate that inflammation may be critically associated with changes in cognitive functioning in older mid-life adults.
Why Does Cognitive Reserve Align With Modern Western Ideals of Success? Theoretical & Methodological Proposals
Authors: Hanes Douglas
Published: December 2021

Cognitive reserve (CR) is a framework that investigates discrepancies between brain pathology and cognitive decline. In explaining why individuals with similar levels of brain pathology display different levels of functional impairment, CR research focuses on factors that resemble modern, Western ideals of success: greater education, professional achievement, a self-directed life, and physically and intellectually stimulating leisure time. This theoretical paper documents this alignment between CR and modern, Western ideals of success to hypothesize different mechanisms by which CR may operate. The focus in the CR literature has been on investigating and operationalizing the direct cognitive changes that come from intellectual cultivation, and the native abilities that are hypothesized to produce differences in both education and cognitive outcomes. This paper argues that an attention to CR’s relationship to current definitions of success presents alternative hypotheses about the mechanisms by which CR operates. Specifically, the paper outlines two potential mechanisms and frames alternative means of studying them: First, does the accrual of CR simply follow from being successful in conventional ways because of the material benefits of wealth and stability that success brings? Second, does a lack of success carry cognitive risks solely because of material deprivation, or are there additional psychosocial penalties that come from living a non-normative life—especially when that is not of one’s choosing? This paper proposes both cross-cultural and intersectional methods to begin to better understand the relationship between normative success and cognitive health.
Interdisciplinary Gerontology in Higher Education: A Case Study From Soup to Nuts
Authors: McGovern Justine
Published: December 2021

Through the lens of a multi-year joint project initiated by faculty in Social Work and Digital Arts at Lehman College, the City University of New York's senior college in the Bronx, NY, this paper provides a guide on how to initiate, implement and evaluate interdisciplinary collaborations in gerontology. The paper also suggests ways to ensure that these collaborations can support tenure and promotion processes, funding initiatives, and pedagogical enhancements. The paper focuses on how to make use of campus resources, including departmental Chairs, research offices, and campus-wide committees to identify appropriate collaborators and funding sources; how to nurture productive interdisciplinary relationships, such as clarifying disciplinary expectations and participants' professional needs; and how to maximize return on the effort for tenure and promotion, such as producing publishable content, identifying appropriate opportunities for interdisciplinary publishing and presenting, advocating for interdisciplinary collaborations, and developing interdisciplinary syllabi, an example of evidence-based high-impact pedagogy.
Sex differences in Speech and High-frequency Hearing Loss Association With Cognitive Impairment Among Older Adults
Authors: Jingru Wang , Ying Yu , Qi Guo
Published: December 2021

Objectives: The purpose of this study was to investigate the relationship between speech-frequency hearing loss (SFHL), high-frequency hearing loss (HFHL), and cognitive impairment (CI). Then to determine whether there are any differences in gender among older community dwellers in China. Methods: This study involved 1,012 adults aged ≥60 years (428 male; average age, 72.61±5.51 years). The participants had their hearing and cognition measured using pure tone audiometry and Mini Mental State Examination (MMSE), respectively. We used the audiometric definition of hearing loss (HL) adopted by the World Health Organization (WHO). Speech-frequencies were measured as 0.5 kHz, 1 kHz, 2 kHz, and 4 kHz; high-frequencies were measured as 4 kHz and 8 kHz. Pure tone average (PTA) was measured as hearing sensitivity. Results: Our studies demonstrated a 37.6% prevalence of HL in males and a 36.0% prevalence of HL in females. Adjusted for confounding variables, the results from a multivariate analysis showed that SFHL was associated with CI in females (OR=2.400, 95% Confidence Interval=1.313–4.385) and males (OR=2.189, 95% Confidence Interval=0.599–2.944). However, HFHL was associated with CI only in females (OR=2.943, 95% Confidence Interval=1.505–5.754). HL was associated with poorer cognitive scores (P<0.05). “Registration” (P<0.05) in MMSE was associated with speech and high-frequency hearing sensitivity. Conclusion: The associations between HL and CI varied according to gender in older community-dwellers, suggesting that different mechanisms are involved in the etiology of HL. Moreover, hearing sensitivity was negatively associated with cognition scores; therefore, early screening for HL and CI among older community-dwelling adults is advised.
Coming Soon to a Class Near You: Cinematic Insights on Later Life
Authors: Brown Candace , Perkinson Margaret
Published: December 2021

Cinema can enhance gerontological education by reinforcing a variety of learning styles, connecting course content to current culture, and providing an alternative, tangible view of what students are learning. The presenters discuss their use of film to teach gerontological concepts in the classroom. In an Introduction to Aging course, the films, “Young at Heart” and “Sunset Story” were used to break through ageist stereotypes, examine examples of resilience at the end of life, and convey the impact of residential context on the experience of aging, i.e., within a retirement home for “retired rebels.” In a course on Health and Aging, movies, such as “Red,” “Driving Miss Daisy,” and “Somethings Gotta Give” are used to compare the social and psychological aspects of aging of the characters to learned concepts in the classroom. Students expressed how watching and writing about the films increased their understanding by bringing abstract gerontological concepts to life.
Home Care Resiliency during the COVID-19 Pandemic: Older Adult-Home Care Aide Dyads’ Perspectives
Authors: Muramatsu Naoko , Yin Lijuan , Caceres Maria , Skowronski Jordan
Published: December 2021

Homecare has increased its value as an alternative to nursing homes and adapted to evolving COVID-19 challenges. However, little is known about how COVID-19 has impacted community-dwelling older adults who need assistance with daily activities, including dressing, cooking, and shopping. Guided by the stress process framework, this mixed-method study examined how older homecare recipients experienced the acute and chronic stress during the first eight months of the pandemic, focusing on the role of home care aides (HCAs) in the context of Medicaid-funded in-home services. Thirty-five dyads of care recipients and HCAs participated in a COVID telephone survey as part of a larger study. Care recipients were typically older minority (40% African American, 31% Latinx) women (77%). Their COVID-related anxiety level, assessed by a 6-item Spielberger State Anxiety Inventory (1 “not at all” to 4 “very much”), was 2.2 (SD=0.9). While COVID-19 drastically reduced contacts with family members and healthcare providers, HCAs continued to provide care in person. One care recipient said, “Fortunately, I still have my HCA come and that keeps me sane.” HCAs showed resilience while facing their own family- and work-related stress: “I have followed the rules and just adapted. (COVID) did not affect the activities for my client.” Some dyads, however, experienced care disruptions because of COVID infection or fear in one or both parties. COVID-19 has demonstrated homecare resilience at the person-, dyad-, and organization-levels, calling for equitable, sustainable home-based care for a growing number of older adults who desire to stay in the home.
Correlates of Resilience of Older People in Times of Crisis
Authors: Albert Isabelle , Hoffmann Martine , Murdock Elke , Nell Josepha , Kornadt Anna
Published: December 2021

Since the beginning of the Covid-19 pandemic, efforts have been made to shield older adults from exposure to the virus due to an age-related higher risk for severe health outcomes. While a reduction of in-person contacts was necessary in particular during the first months of the pandemic, concerns about the immediate and longer-term secondary effects of these measures on subjective well-being were raised. In the present study, we focused on self-reported resilience of older people in a longitudinal design to examine risk and protective factors in dealing with the restrictions. Data from independently living people aged 60+ in Luxembourg were collected via a telephone/online survey after the first lockdown in June (N = 611) and September/October 2020 (N = 523), just before the second pandemic wave made restrictions necessary again. Overall, results showed an increase in life-satisfaction from T1 to T2, although life-satisfaction was still rated slightly lower than before the crisis. Also, about a fifth of participants indicated at T2 difficulties to recover from the crisis. Participants who reported higher resilience to deal with the Covid-19 crisis at T2 showed higher self-efficacy, agreed more strongly with measures taken by the country and felt better informed about the virus. In contrast, participants who reported more difficulties in dealing with the pandemic, indicated reduced social contacts to family and friends at T2, and also felt lonelier. Results will be discussed applying a life-span developmental and systemic perspective on risk and protective factors in dealing with the secondary impacts of the pandemic.
Perceived Impact of COVID-19 on Older Adults’ Mental Health and Barriers to Mental Health Care
Authors: Caskie Grace , Tschauner Madison , Root Eve
Published: December 2021

COVID-19 disproportionately impacted older adults in terms of fatalities, but also increased stress, isolation, and loneliness (Chen, 2020). We examined older adults’ anxiety, depression, and barriers to mental healthcare during the COVID-19 pandemic and their perceptions of these variables prior to the pandemic. Further, we explored whether any perceived changes differed based on geographical location (rural, suburban, urban). Data were collected online between mid-June and mid-July of 2020 from 244 individuals aged 65-82 years (M=68.3, SD=3.5). The sample was primarily White (91%) and female (60%); most (n=119) lived in suburban settings, with 63 in urban and 60 in rural settings. Repeated-measures ANOVAs at alpha=.01 showed that depressive symptoms, measured by the CESD-10 (p<.001), and anxiety symptoms, measured by the GAD-7 (p<.001), increased during the pandemic as did mental healthcare barriers related to transportation (p=.004) and beliefs that depression is a normal part of aging (p<.001). Only transportation concerns differed based on where older adults lived; those in rural (p<.001) and urban (p=.004) settings reported greater transportation barriers than those in suburban settings. No differences over time were found for barriers related to help-seeking (p=.403), stigma (p=.156), knowledge/fear (p=.180), finding a therapist (p=.030), ageism (p=.302), psychotherapist qualifications (p=.265), physician referrals (p=.207), or finances (p=.818). These findings highlight the impact of COVID-19 on older adults’ perceptions of changes in their psychological well-being as well as their experience navigating mental health services.
Social Isolation, Depressive Symptoms and Perceived Neighborhood Environment of Older Adults During COVID-19
Authors: Li Ke , Tang Fengyan
Published: December 2021

Social isolation has been recognized as a social problem with negative effects on psychological well-being. Older adults are disproportionately affected by social isolation during the COVID-19 pandemic. Using data from the 2020 Health and Retirement Study COVID-19 Project, this study examined the relationship between social isolation and depressive symptoms among two groups of respondents differentiated by whether themselves or their social relationships were diagnosed with COVID-19. This study also explored the moderating role of perceived neighborhood environment. Depressive symptoms were measured using the eight-item CES-D. The index of social isolation was generated using five indicators, including living alone, no social participation, and less than monthly contact with children, family members, and friends. The moderator assessed two aspects of the neighborhood environment, including physical disorder and social cohesion. The results of bivariate analyses showed that respondents who were affected by COVID-19 were younger, more likely to be female, Hispanic, and Non-Hispanic Black, and with lower levels of social isolation. The results of multiple regression analyses indicated that social isolation was associated with more depressive symptoms, but this relationship was found to be only significant among respondents who were affected by COVID-19. Perceived neighborhood environment significantly moderated the relationship, as the effect of social isolation on depressive symptoms was stronger for respondents with more neighborhood physical disorders and less social cohesion. This study has implications for practice and policy, in that it underscored the importance of enacting strategies to improve the neighborhood environment, particularly for socially isolated older adults during the COVID-19.
Timeline of COVID-19 Incidence and Mortality among Residents and Staff of South Carolina Long-term Care Facilities
Authors: Lohman Matthew , Resciniti Nicholas , Fuller Morgan , Sellner Joshua
Published: December 2021

The COVID-19 pandemic has disproportionately impacted older adults living in long-term care facilities (LTCFs), but little research has described parallel infection rates and mortality among LTCF residents and staff in relation to state-level mitigation measures. This study used comprehensive COVID-19 tracking data from the South Carolina Department of Health and Environmental Control (SCDHEC), including case report information on demographics, symptoms, comorbidities, and employment. We included all confirmed or probable COVID-19 cases and deaths among adult SC residents reported between 3/15/2020 and 1/2/2021. Residence or employment in LTCF, including nursing homes, assisted living, or skilled nursing facilities, were confirmed by SCDHEC. Cox proportional hazards models were used to compare mortality between residents/staff and counterparts in the community. Overall, 54,514 cases of COVID-19 were identified among older adults in SC. Of these, 13.5% (n = 7,366) resided in a LTCF. LTCF residents with COVID-19 were more likely to be hospitalized compared to older adults in the community and 74% more likely to die (HR= 1.74, 95% CI: 1.59-1.90), after controlling for age, gender, race, and chronic health conditions. LTCF staff had greater infection rates but lower risk of mortality (HR=0.58; 95% CI: 0.39-0.88) compared to the general population. Differences in COVID-19 incidence and mortality between residents/staff and the community decreased after statewide mitigation policies. This study indicates that LTCF residents are at increased risk of COVID infection and mortality, even accounting for pre-existing health conditions. LTCF settings are key sites for prioritizing prevention, vaccination, and training plans to prepare for future pandemics.
Transforming Virtual Team-Based Learning for Rural Healthcare Staff: What the Pandemic Taught Us
Authors: Gottesman Eve , Fernandez Helen , Howe Judith
Published: December 2021

During COVID-19, many training programs pivoted to virtual formats. For the Rural Interdisciplinary Team Training (RITT) Program, funded by the Veterans Health Administration as part of the Geriatric Scholars Program, there were unique challenges. Given a history of successful accredited in-person, team-based workshops for staff at rural and remote clinics, program developers needed to quickly devise a plan for an effective virtual training for team members working separately from each other. Without the ability to provide in-person education and training, rapid pivoting to virtual modalities was essential for ongoing education of those providing care for older adults. Using a web-based platform, team members and expert trainer facilitation, participants engaged in lively discussions and reflection using the chat feature. RITT adapted the curriculum to better meet the needs of busy healthcare providers working during the pandemic, including increased discussion of how COVID affects older Veterans. Three virtual RITT workshops were held between March 2020 and February 2021 with 64 participants from 12 rural clinics and medical centers. Over 90% of participants agreed or strongly agreed that they were satisfied with the virtual workshop, comparable to those participating in the in-person workshop in earlier years. Similar to others, we have found that the ability to flex a curriculum has benefits to both learners and educators and increases the reach of educational opportunities in gerontology and geriatrics. Particularly in rural areas where travel may be challenging, a virtual format may be a desirable long-term solution for the RITT program.
Aging, Empathy, and Prosocial Behaviors During the COVID-19 Pandemic
Authors: Cho Isu , Daley Ryan , Cunningham Tony , Kensinger Elizabeth , Gutchess Angela
Published: December 2021

Previous literature has shown age-related increases in prosociality (i.e., the tendency to engage in behaviors that benefit others). Can such age-related differences be observed during the COVID-19 pandemic, or would young adults’ higher levels of COVID-19-related stress alter the relation between age and prosociality given the prior findings that stress may promote prosocial behaviors? Can empathy, one of the factors highly related to prosociality, explain any observed age-related differences? The current study examined the above questions, as well as whether age differences exist in target of prosocial behaviors (i.e., distant- versus close-others). To this end, participants (aged 18-89) enrolled in an ongoing study examining their experiences during the COVID-19 pandemic. They were asked to complete a series of surveys on dispositional empathy and prosocial behaviors during the pandemic. In the present analyses, the data were used from 330 participants from the USA who completed all of the surveys. Compared to younger adults, results indicate that older adults showed greater prosocial behaviors during the pandemic despite their higher risk of physical-health complications from COVID-19. Unexpectedly, empathy did not explain such age-related increases in prosocial behaviors even though it was positively related to individuals’ prosociality. Interestingly, older adults reported increased prosocial behaviors towards close-others (i.e., family, friends) compared to young adults, suggesting that older adults seem to devote more resources into emotionally meaningful relationships. The current study contributes to our understanding of how prosociality differs with age during the stressful period of need that marks the COVID-19 pandemic.
COVID-19 Concerns, Depression and Loneliness in Middle-Age and Older Adults
Authors: Curl Angela , Wolf Katie
Published: December 2021

The coronavirus pandemic forced many people to restrict their activities and social interactions out of fear and due to local health regulations. This study examined whether one’s self-reported level of concern related to COVID-19 was associated with loneliness and depressive symptoms. Using early release 2020 data from the Health and Retirement Study (N=2,759 adults over age 50), we conducted ordinary least-squares and logistic regressions, controlling for age, gender, education, marital status, self-rated health, and exercise. Higher levels of self-reported concern about the coronavirus pandemic were associated with more depressive symptoms (B=.05, p<.01) and increased odds of being lonely (OR=1.05, p<.01). Female sex, lower education, not being married, worse self-rated health, and lack of exercise were associated with more depressive symptoms and higher odds of being lonely, while older age was associated with lower depression but higher odds of loneliness. These results suggest that mental health assessments should include measures specifically asking about COVID-19 concerns and experiences (e.g., COVID-19 diagnosis, death of close friends or family due to COVID-19, unable to attend important events). The pandemic has raised public awareness of the negative consequences of social isolation and acted to destigmatize mental illness, and this could encourage middle-aged and older adults to seek professional help for depression.