bluuebunny/crossref_metadata_2025 huggingface dataset:
Three RET germ-line mutations in a family with multiple endocrine neoplasia type 2A syndrome
Authors: Severskaya Natalia V , Polyakov Vladimir G , Shishkov Ruslan V , Ilin Alexey A , Ivanova Natalia V , Pavlovskaya Alevtina I. , Kozlova Valentina M. , Amosenko Faina A. , Lyubchenko Liudmila N. , Kazubskaya Tatyana P. , Koshechkina Natalia A. , Mikhailova Elena V. , Matveeva Irina I. , Serebryakova Irina N. , Mikhailova Svetlana N. , Kalinchenko Natalia Y.
Published: January 2017

Multiple mutations in RET proto-oncogene are not common findings in patients with multiple endocrine neoplasia type 2A syndrome (MEN2A). Screening for RET mutation in MEN2A family members is usually limited by the known affected exon. However the second unrevealed mutation in RET proto-oncogene can coexist and modify the phenotype of MEN2 patients, including age of onset of medullary thyroid carcinoma, penetrance of pheochromocytoma etc. We here describe a family with MEN 2A syndrome with combination of three different germ-line RET mutations in its members (RET codon C634R, C634R+I852M, I852M+Y791F, Y791F). The earliest onset of medullary thyroid carcinoma was in a patient harboring the C634R+I852M double mutation at age 24 years. A 49-y.o.patient with C634R mutation has persistent medullary thyroid carcinoma after thyroidectomy at 35 years old. A carrier of Y791F mutation had no clinical evidence of disease at age of 28 years. In a child with compound I852M+Y791F mutation preventive thyroidectomy revealed C-cell hyperplasia at age of 4 years. The clinical significance of double RET mutation in the described family is not clear. Literature data of multiple germ-line RET mutations in patients with multiple endocrine neoplasia type 2A syndrome are presented.
Effect of oxidative stress on major plasma carotenoid content and composition in prepubertal children with growth hormone deficiency
Authors: Pankratova Maria S. , Yusipovich Alexander I. , Vorontsova Maria V. , Knyazeva Tila T. , Baizhumanov Adil A. , Shiryaeva Tatiana Y. , Solovchenko Alexey E. , Maksimov Georgy V. , Peterkova Valentina A.
Published: January 2017

Objective and hypotheses. This study aimed at examining the effect of oxidative stress on amount and composition of major plasma carotenoids in prepubertal children with growth hormone deficiency (GHD).Material and methods. Thirteen prepubertal treatment-naive children (2 girls, 11 boys; aged 3.5—12.0 yr, median 8.0 years; bone age 1.5—8.0 yr; median 6.0 years,) with GHD and 7 prepubertal health children (7 boys; aged 6—11 years; median 9.3 years) were included in the study. The levels and composition of carotenoids (lutein with zeaxanthin, lycopene isomers, β-cryptoxanthin, β- and α-carotene and ketocarotenoids) were measured using reverse phase HPLC. Activity of the antioxidant system was assayed via thiobarbituric acid reactive substances (TBARS), ceruloplasmin (CP) levels and total antioxidant capacity (TAC) of plasma. Total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and triglycerides (TG) were also measured.Results. The levels of TBARS, TC and LDL-C in the GHD children were higher than in healthy children (median 5.6 vs 3.8 µM/L, 4.00 vs 4.37 and 2.40 vs 2.70 mM/L, respectively). Total carotenoid level did not significantly differ between control and the GHD groups. However, contents of lutein and β-cryptoxanthin were significantly lower in the GHD children in comparison with control group (21.34 vs 6.97 and 25.23 vs 10.08 mg/l, respectively). In contrast, levels of lycopene, α- and β-carotene did not significantly differ in the GHD and control groups. At the same time, the level of ketocarotenoids in the GHD children increases (35.67 vs 114.9 mg/l).Conclusions. We observed that the presence of mild oxidative stress leads to a changes in carotenoid profile of GHD children.
Clinical presentation and management of mycetoma in gezira mycetoma center in Sudan
Authors: Ahmed Moiez M. Aboudi , Alshiekh Ahmad Alamin , Awadalla Mohammed D. , Alawad Awad Ali M.
Published: January 2017

Background: Mycetoma is a neglected tropical disease characterised by deformity and disabilities with various medical, health, and socioeconomic impacts on the affected communities. It is a common health problem in Gezira state in Sudan.Objective: This study was conducted to review the clinical presentation and management of mycetoma in Gezira Mycetoma Center in Medani, Sudan.Methodology: This was a prospective descriptive health facility-based study conducted among 100 patients diagnosed with mycetoma attended to Gezira Mycetoma Center during the period from October 2014 to Sept. 2015. Variable checked was demographic characteristic, clinical presentation, types of mycetoma, and types of surgery done.Results: The commonest age was 20-40 years, which represents 49(49%). Males were 76(76%). Participants were mostly farmers or animal breeders with percentage of 31% and 12% respectively. All patients presented with a swelling (100%) and mostly with discharge in a sinuses (75%).The vast majority of patients reside in Gezira State (82%). Eumycetoma was reported in 98% of cases versus 2% actinomycetoma. Diagnosis depended on clinical examination mainly and X-ray for bone involvement which was reported in 15%. All cases underwent surgical intervention in the form of wide local excision (81%), amputation (17%) and debulking (2%).Conclusion: The study concluded that most of the patients presented late, with history of inadequate management.
William Livingston and New Jersey’s Revolutionary Environment
Authors: Gigantino II James J.
Published: January 2017

The impact of the environment on the American Revolution in New Jersey cannot be understated as environmental factors ranging from climate to crop yields to geography all intensely impacted the course of the Revolution. This talk, delivered on November 18th at the opening reception of the NJ Historical Commission’s 2016 NJ Forum, explores the relationship between the natural environment and military and political policies through the eyes of William Livingston, New Jersey’s first governor. Throughout the conflict, the environment became a constant actor and foil to Livingston, forcing him to make political decisions in tandem with not only British movements but more frequently, owing to climatic, geographic, or agricultural factors. In addition to looking at Livingston, the article examines the interplay between Livingston and his own conceptions on the environment from his pre-revolutionary past. Finally, the article discusses how average New Jerseyans understood the role of his revolutionary government in the context of various environmental factors. Most Jersey farmers and landless laborers based their support for the revolutionary movement not on ideology but on environmental factors that constantly challenged their loyalty to both sides.
Rediscovering Aldo Leopold’s Big Woods
Authors: Druckenbrod Daniel L.
Published: January 2017

While much of Aldo Leopold’s life is associated with Wisconsin, where he wrote A Sand County Almanac, his observations and letters as a high school student in Lawrenceville, New Jersey document his maturing insights into natural history and his eventual land ethic. This article frames Leopold’s experiences at the Lawrenceville School within the context of its surrounding environment in 1904-1905 by rediscovering the locations of forests he drew on a map in a letter to his mother. Notably, Leopold referred to the forest west of Rider University today as the Big Woods. Tree-ring data recently collected by Rider University students and other historical evidence (including an oral interview, photographs, 1899 state government report, and 1849 herbarium sample) confirm the location of this forest and reveal that it has been present since at least the mid-nineteenth century. Knowing the locations of these forests, like Leopold’s Big Woods, not only enables a greater appreciation for the landscape that he wrote extensively about in letters home, but also provides an opportunity to document the long-term environmental changes that have occurred over the past 110 years in central New Jersey.
New Jersey Governor Brendan Byrne: The Man Who Couldn’t Be Bought
Authors: Birkner Michael J.
Published: January 2017

Birkner's review of New Jersey Governor Brendan Byrne: The Man Who Couldn’t Be Bought, by Linky.
Experimental Study Regarding of Bending Behaviour of Stabilizator Link
Authors: Cofaru Nicolae , Roman Lucian , Pascu Adrian , Oleksik Valentin
Published: January 2017

This paper presents an experimental study of the behavior of anti-roll power link subjected to bending, power link coming from an Opel Astra G. The power link is made of PA66 GF30 polyamide. For this study, there were used a universal testing machine (Instron 5587) and a real-time strain measurement optical system (Aramis). The results showed are those obtained in the case of a compression force of 1,000 [N] namely: major Strain ε1, minor strain ε2, equivalent von Mises strain, displacement on X axis, displacement on Y axis (compression force direction), displacement on Z axis.
About the Smart Weather Station
Authors: Bogdan Mihai
Published: January 2017

Until recently, the Romanian weather stations utilized ordinary transducers that acquire useful information related to the desired physical inputs. These inputs will be converted into electrical signals easy to be processed by analog to digital converters.

This paper proposed a new approach based on smart sensors system that change the interior behavior in order to optimize data acquirements from the environment. The smart sensor characteristics are stored into himself in a transducer electronic data sheet form (TEDS). The intelligent transducer generat together with the measured analogic signal also a digital interface. Through this interface the transducer’s catalog data can be read from the transducer.
Some Numerical Results of Multipoints Bomndary Value Problems Arise in Environmental Protection
Authors: Pop Daniel N.
Published: January 2017

In this paper, we investigate two problems arise in pollutant transport in rivers, and we give some numerical results to approximate this solutions. We determined the approximate solutions using two numerical methods: 1. B-splines combined with Runge-Kutta methods, 2. BVP4C solver of MATLAB and then we compare the run-times.
Cohomology and torsion cycles over the maximal cyclotomic extension
Authors: Rössler Damian , Szamuely Tamás
Published: January 2017

A classical theorem by K. Ribet asserts that an abelian variety defined over the maximal cyclotomic extension K of a number field has only finitely many torsion points. We show that this statement can be viewed as a particular case of a much more general one, namely that the absolute Galois group of K acts with finitely many fixed points on the étale cohomology with

𝐐
/
𝐙

{\mathbf{Q}/\mathbf{Z}}

-coefficients of a smooth proper

K
¯

{\overline{K}}

-variety defined over K. We also present a conjectural generalization of Ribet’s theorem to torsion cycles of higher codimension. We offer supporting evidence for the conjecture in codimension 2, as well as an analogue in positive characteristic.
CFD Analysis and Design Optimization in a Curved Blade Impeller
Authors: Sutudehnezhad Nazila , Zadghaffari Ramin
Published: January 2017

Mixing efficiency in stirred tank reactors is an important challenge in the design of many industrial processes. The effect of blade shape on mixing efficiency has been studied in the present work. The computational method has been used to investigate the flow field, power consumption, pumping capacity, hydraulic efficiency, and mixing time in a fully baffled tank stirred by a Rushton turbine and different curved blade impellers. Flow in a stirred tank reactor involves interactions between flow around rotating blades and stationary baffles. The flow field was developed using the sliding mesh (SM) approach in computational fluid dynamics (CFD). The realizable k-ε was used to model the turbulence. A reasonable agreement between the experimental reported data and simulation results indicated the validity of CFD model. It has been revealed that increasing the blade curvature, at approximately the same mixing time would enhance the mixing efficiency up to 61.3 % in comparison with the Rushton turbine. This mixing efficiency would favor the employment of curved blade impellers due to the cost-benefits of stirred tank operations.
The BNS-invariant for some Artin groups of arbitrary circuit rank
Authors: Almeida Kisnney
Published: January 2017

We classify the Bieri–Neumann–Strebel invariant

Σ
1

⁢

(
G
)

{\Sigma^{1}(G)}

for a class of Artin groups with minimal graphs of arbitrary circuit rank.
Sialoendoscopy, sialography, and ultrasound: a comparison of diagnostic methods
Authors: Pniak Tomáš , Štrympl Pavel , Staníková Lucia , Zeleník Karol , Matoušek Petr , Komínek Pavel
Published: January 2017

Objective

To compare the accuracy of ultrasound, sialography, and sialendoscopy for examining benign salivary gland obstructions.

Methods

In this prospective study, patients with symptoms of obstruction of the major salivary gland duct system presenting at the ENT Clinic University Hospital, Ostrava, from June 2010 to December 2013 were included. All patients (n=76) underwent ultrasound, sialography, and sialoendoscopy. The signs of sialolithiasis, ductal stenosis, or normal findings were recorded after the examinations. Statistical analysis of the sensitivity and specificity of all the methods was performed, as well as a comparison of the accuracy of each method for different kinds of pathology (sialolithiasis or stenosis).

Results

The sensitivity of ultrasound, sialography, and sialoendoscopy for sialolithiasis findings were 71.9%, 86.7 %, and 100%, respectively. The sensitivity of sialography and sialoendoscopy for stenosis of the duct was 69.0%, and 100%, respectively. The study showed impossibility of ultrasonic diagnostics of ductal stenosis. The sensitivity of sialoendoscopy for both pathologies was significantly higher than that from ultrasound or sialography (p<0.05). The specificity of sialoendoscopy was significantly higher than that from by ultrasound or sialography (p<0.05).

Conclusion

Sialoendoscopy was the most accurate method for examination ductal pathology, with significantly higher sensitivity and specificity than by ultrasound or sialography.
Use of a simplified consent form to facilitate patient understanding of informed consent for laparoscopic cholecystectomy
Authors: Borello Alessandro , Ferrarese Alessia , Passera Roberto , Surace Alessandra , Marola Silvia , Buccelli Claudio , Niola Massimo , Di Lorenzo Pierpaolo , Amato Maurizio , Di Domenico Lorenza , Solej Mario , Martino Valter
Published: January 2017

Background

Surgical informed consent forms can be complicated for patients to read and understand. We created a consent form with key information presented in bulleted texts and diagrams combined in a graphical format to facilitate the understanding of information during the verbal consent discussion.

Methods

This prospective, randomized study involved 70 adult patients awaiting cholecystectomy for gallstones. Consent was obtained after standard verbal explanation using either a graphically formatted (study group, n=33) or a standard text document (control group, n=37). Comprehension was evaluated with a 9-item multiple-choice questionnaire administered before surgery and factors affecting comprehension were analyzed.

Results

Comparison of questionnaire scores showed no effect of age, sex, time between consent and surgery, or document format on understanding of informed consent. Educational level was the only predictor of comprehension.

Conclusions

Simplified surgical consent documents meet the goals of health literacy and informed consent. Educational level appears to be a strong predictor of understanding.
The potential of hybrid potato for East-Africa
Authors: de Vries Michiel , ter Maat Menno , Lindhout Pim
Published: January 2017

Potato is an important staple crop in East Africa.
Most of the seed tubers are propagated in informal systems,
whereby the tubers become deteriorated and contaminated,
resulting in low crop yields. Potato breeding has not
resulted in significantly improved varieties that overcome
these constraints. Recently, true potato hybrid breeding
technology has been developed, whereby diploid hybrids
are generated by crossing between homozygous inbred
parent lines. The first series of experimental hybrids were
pre-screened in The Netherlands and ten representative
hybrids were tested in East-Africa, whereby the yield of the
best hybrid was 29 ton/ha. These results show the great
potential of hybrid potato for East Africa.
Modeling and optimization of Quality of Service routing in Mobile Ad hoc Networks
Authors: Rafsanjani Marjan Kuchaki , Fatemidokht Hamideh , Balas Valentina Emilia
Published: January 2017

Mobile ad hoc networks (MANETs) are a group of mobile nodes that are connected without using a fixed infrastructure. In these networks, nodes communicate with each other by forming a single-hop or multi-hop network. To design effective mobile ad hoc networks, it is important to evaluate the performance of multi-hop paths. In this paper, we present a mathematical model for a routing protocol under energy consumption and packet delivery ratio of multi-hop paths. In this model, we use geometric random graphs rather than random graphs. Our proposed model finds effective paths that minimize the energy consumption and maximizes the packet delivery ratio of the network. Validation of the mathematical model is performed through simulation.
Non-local Integrals and Derivatives on Fractal Sets with Applications
Authors: Golmankhaneh Alireza K. , Baleanu D.
Published: January 2017

In this paper, we discuss non-local derivatives on fractal Cantor sets. The scaling properties are given for both local and non-local fractal derivatives. The local and non-local fractal differential equations are solved and compared. Related physical models are also suggested.
MODY – calculation of ordered structures by symmetry-adapted functions
Authors: Białas Franciszek , Pytlik Lucjan , Sikora Wiesława
Published: January 2017

In this paper we focus on the new version of computer program MODY for calculations of symmetryadapted functions based on the theory of groups and representations. The choice of such a functional frame of coordinates for description of ordered structures leads to a minimal number of parameters which must be used for presentation of such structures and investigations of their properties. The aim of this work is to find those parameters, which are coefficients of a linear combination of calculated functions, leading to construction of different types of structure ordering with a given symmetry. A spreadsheet script for simplification of this work has been created and attached to the program.
Sensorik und Messtechnik für die Industrie 4.0
Authors: Schütze Andreas , Helwig Nikolai
Published: January 2017

Dieser Beitrag
betrachtet zunächst allgemein die Bedeutung von Sensorik und Messtechnik
für die Industrie 4.0 und
versucht, den nach wie vor schwammigen Begriff Industrie
4.0 für den Bereich Sensorik und Messtechnik als
Sensor 4.0 zu konkretisieren.
Anschließend wird kurz die Erwartungshaltung aus Sicht der Industrie
4.0 an moderne Sensorik und Messtechnik
reflektiert, bevor der heutige Stand der Technik und die
weitere Entwicklung skizziert werden. Konkrete Beispiele
smarter Sensor- und Messsysteme für die Industrie
4.0 aus dem Bereich hochintegrierter magnetischer
Sensoren sowie Anwendungen wie dem Condition Monitoring komplexer Anlagen
auf Basis verteilter Sensoren verdeutlichen das Potential und die noch
anstehenden Herausforderungen. Gerade das Condition
Monitoring als Voraussetzung für eine zustandsbasierte Wartung von
Systemen, aber auch für ein autonomes Aushandeln von
Fertigungsprozessen muss neben dem Zustand von Prozess und Maschine auch
mögliche Sensorausfälle bzw. die aktuelle
Fertigungsgenauigkeit berücksichtigen. Hierzu
zählt auch eine erweiterte Betrachtung der Messunsicherheit für
statistische bzw. allgemein datenbasierte
Auswertemodelle, da bei diesen
u. a. gezielt Korrelationen in
komplexen Systemen ausgenutzt werden, um den Zustand
einzelner Komponenten bewerten zu können.
Diskussion der Messunsicherheitsbeiträge am Beispiel aktueller Druckmesstechnik
Authors: Schiering Nadine , Schnelle-Werner Olaf
Published: January 2017

Druckmessgeräte werden von akkreditierten Kalibrierlaboratorien nach der Richtlinie DKD-R 6-1

DKD-R
6-1:2014. Kalibrierung von Druckmessgeräten. Deutscher Kalibrierdienst (DKD) unter Schirmherrschaft der
Physikalisch-Technischen Bundesanstalt (PTB), Ausgabe 03/2014.

kalibriert. Diese Richtlinie legt Mindestanforderungen an
das Kalibrierverfahren und an die Messunsicherheitsbetrachtung bei der Kalibrierung von Druckmessgeräten fest. Die
Bestimmung der Messunsicherheit erfolgt dabei grundsätzlich nach dem in der Schrift DAkkS-DKD-3 beschriebenen
Verfahren. Der vorliegende Beitrag stellt die Herangehensweise vor, wie die Messunsicherheit bei der Kalibrierung von
Druckmessgeräten berechnet werden kann. Des Weiteren wird auf die einzelnen Unsicherheitsbeiträge und deren Ermittlung
bzw. Herkunft eingegangen. Abschließend wird als Ergebnis eine Beispiel-Messunsicherheitsbilanz aufgezeigt, welche ein
wichtiges Tool bei der Messunsicherheitsberechnung darstellt.
Synthesis and characterization of a macrocyclic copper complex containing the 14-membered 1,3,5,8,10,12-hexaazacyclotetradecane unit
Authors: Hakimi Mohammad , Mardani Zahra , Moeini Keyvan , Mohr Fabian
Published: January 2017

In this work, a new macrocyclic copper complex, [Cu(ACE)(SCN)2]; ACE: 1,3,6,10,12,15-hexaazatricyclo[13.3.1.16,10]eicosane, was prepared and characterized by elemental analysis, FT-IR, Raman spectroscopy and single-crystal X-ray diffraction. X-ray analysis of [Cu(ACE)(SCN)2] reveals an elongated octahedral geometry around the copper atom in a centrosymmetric CuN6 environment.
Characteristics of Patients With Satisfactory Functional Gain Following Total Joint Arthroplasty in a Postacute Rehabilitation Setting
Authors: Hershkovitz Avital , Vesilkov Marina , Beloosesky Yichayaou , Brill Shai
Published: January 2017

Background and Purpose:

Total joint arthroplasty (TJA) is an effective and successful treatment of osteoarthritis of the hip and knee as quantified by several measures, such as pain relief, improved walking, improved self-care, functions, and increased quality of life. Data are lacking as to the definition of a satisfactory functional gain in a postacute setting and identifying the characteristics of older patients with TJA who may achieve that gain. Our aim was to characterize patients who may achieve a satisfactory functional gain in a postacute rehabilitation setting following TJA.

Methods:

This was a retrospective study of 180 patients with TJA admitted during 2010-2013. The main outcome measures were the Functional Independence Measure (FIM), the Montebello Rehabilitation Factor Score (MRFS) on the motor FIM, and the Timed Get Up and Go Test. Satisfactory functional gain was defined as an mFIM MRFS score above median score. Comparisons of clinical and demographic characteristics between patients who achieved a satisfactory functional gain versus those who did not were performed by the Mann-Whitney U test and the χ2 test.

Results:

The proportion of patients who achieved a satisfactory functional gain was similar in the total knee arthroplasty and total hip arthroplasty (THA) groups. The most significant characteristic of patients who achieved a satisfactory functional gain was their admission functional ability. Age negatively impacted the ability to achieve a satisfactory functional gain in patients with THA.

Conclusion:

Functional level on admission is the best predictive factor for a better rehabilitation outcome for patients with TJA. Age negatively affects functional gain in patients with THA.
Calcium‐permeable AMPA receptors and silent synapses in cocaine‐conditioned place preference
Authors: Shukla Avani , Beroun Anna , Panopoulou Myrto , Neumann Peter A , Grant Seth GN , Olive M Foster , Dong Yan , Schlüter Oliver M
Published: January 2017

Exposure to cocaine generates silent synapses in the nucleus accumbens (NAc), whose eventual unsilencing/maturation by recruitment of calcium‐permeable AMPA‐type glutamate receptors (CP‐AMPARs) after drug withdrawal results in profound remodeling of NAc neuro‐circuits. Silent synapse‐based NAc remodeling was shown to be critical for several drug‐induced behaviors, but its role in acquisition and retention of the association between drug rewarding effects and drug‐associated contexts has remained unclear. Here, we find that the postsynaptic proteins PSD‐93, PSD‐95, and SAP102 differentially regulate excitatory synapse properties in the NAc. Mice deficient for either of these scaffold proteins exhibit distinct maturation patterns of silent synapses and thus provided instructive animal models to examine the role of NAc silent synapse maturation in cocaine‐conditioned place preference (CPP). Wild‐type and knockout mice alike all acquired cocaine‐CPP and exhibited increased levels of silent synapses after drug‐context conditioning. However, the mice differed in CPP retention and CP‐AMPAR incorporation. Collectively, our results indicate that CP‐AMPAR‐mediated maturation of silent synapses in the NAc is a signature of drug–context association, but this maturation is not required for establishing or retaining cocaine‐CPP.
Dynamic GnRH and hCG testing: establishment of new diagnostic reference levels
Authors: Bang A Kirstine , Nordkap Loa , Almstrup Kristian , Priskorn Lærke , Petersen Jørgen Holm , Rajpert-De Meyts Ewa , Andersson Anna-Maria , Juul Anders , Jørgensen Niels
Published: January 2017

Objective

Gonadotropin-releasing hormone (GnRH) and human chorionic gonadotropin (hCG) stimulation tests may be used to evaluate the pituitary and testicular capacity. Our aim was to evaluate changes in follicular-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone after GnRH and hCG stimulation in healthy men and assess the impact of six single nucleotide polymorphisms on the responses.

Design

GnRH and hCG stimulation tests were performed on 77 healthy men, 18–40 years (reference group) at a specialized andrology referral center at a university hospital. The potential influence of the tests was illustrated by results from 45 patients suspected of disordered hypothalamic–pituitary–gonadal axis.

Methods

Baseline, stimulated, relative and absolute changes in serum FSH and LH were determined by ultrasensitive TRIFMA, and testosterone was determined by LC–MS/MS.

Results

For the reference group, LH and FSH increased almost 400% and 40% during GnRH testing, stimulated levels varied from 4.4 to 58.8 U/L and 0.2 to 11.8 U/L and FSH decreased in nine men. Testosterone increased approximately 110% (range: 18.7–67.6 nmol/L) during hCG testing. None of the polymorphisms had any major impact on the test results. Results from GnRH and hCG tests in patients compared with the reference group showed that the stimulated level and absolute increase in LH showed superior identification of patients compared with the relative increase, and the absolute change in testosterone was superior in identifying men with Leydig cell insufficiency, compared with the relative increase.

Conclusions

We provide novel reference ranges for GnRH and hCG test in healthy men, which allows future diagnostic evaluation of hypothalamic–pituitary–gonadal disorders in men.
La representación social como vinculación entre agentes sociales y el espacio urbano en el distrito central de Barva, Heredia, Costa Rica.
Authors: Otárola Guevara Marcela
Published: January 2017

Este artículo muestra la vinculación entre agentes sociales y el espacio urbano en la comunidad de Barva, mediante la develación de representaciones sociales que priman en la mentalidad de sus habitantes y se proyectan en la configuración de la ciudad. La acción de esos agentes incide en la morfología física y simbólica de la urbe, transformándola.
La guerra salvadoreña vista desde la literatura autoficcional: Dios tenía miedo, de Vanessa Núñez Handal
Authors: Grinberg Pla Valeria
Published: January 2017

This article analizes the labors of memory in Vanessa Núñez Handal’s novel Dios tenía miedo. By looking into both the familial and the national past in El Salvador through an autofictional exploration of the ways in which her own family was involved in the war she herself experienced as a child, Vanessa Núñez Handal experiments with the explanatory potential of both the creative imagination and the use of symbolic language, in a process where writing seems to be as much a method as a goal in order to remember and, above all, understand the percepticide that took place during the war. The ambiguity of the autofictional pact rules over the novel, giving her the liberty to combine fictional, autobiographical, and testimonial techniques, with the aim of articulating her interpretation of the traumatic past.
La Educación Geográfica y la Formación Ciudadana: Conceptualización, vinculación y puesta en práctica
Authors: Vargas Hernández Annie
Published: January 2017

Este artículo consiste en una revisión bibliográfica que busca analizar los diferentes conceptos que se han planteado alrededor de las disciplinas de la educación geográfica y la formación ciudadana, por medio de, por un lado, las comparaciones entre las diferentes concepciones y, por otro lado, buscando la vinculación entre ellas. Con esto, el objetivo es aclarar el objeto de estudio de la educación geográfica y la formación ciudadana, en el que se pueda encontrar el punto de convergencia entre ambas, así como ejemplificar la puesta en práctica de su enseñanza.
Las amenazas naturales en Costa Rica: Abordaje desde la Enseñanza de Estudios Sociales y Educación Cívica
Authors: Zúñiga Arias Ana Yolanda , Ledezma Díaz Rafael Angel
Published: January 2017

El artículo se derivada de la investigación “Huracanes en Costa Rica: impacto agroecológico y riesgo social, 1970-2010” realizada por Yolanda Zúñiga y Rafael Ledezma en la escuela de Historia de la Universidad Nacional. En ese trabajo se analiza el tema de las amenazas naturales en Costa Rica, en el que se enfatiza el impacto provocado por fenómenos hidrometeorológicos. El objetivo de este artículo consiste en brindar información complementaria a los programas de estudio y a las actividades didácticas sobre el impacto agroecológico y el riesgo social como temas que pueden ser aplicados en las lecciones de Estudios Sociales y Educación Cívica. La investigación se desarrolló mediante el uso de fuentes primarias y secundarias sobre el riesgo y la vulnerabilidad, leyes y decretos, informes de la Comisión Nacional de Emergencias y artículos periodísticos. Con este artículo se pretende contribuir a la consolidación de una ciudadanía responsable y preparada ante el impacto provocado por los fenómenos naturales en la sociedad costarricense
Formación universitaria y acciones educativas para comprender la “Costa Rica verde”. Una propuesta educativa desde la disciplina histórica.
Authors: Pizarro Méndez Yanina
Published: January 2017

El artículo detalla la experiencia docente desarrollada en el curso optativo de Historia Ambiental de Costa Rica, impartido por la Escuela de Historia para la formación ambiental del estudiantado universitario, entre el 2013 y el 2015, como corolario de maduración del Observatorio de Historia Agroecológica Ambiental (OHAA). Para ello, se precisa un renovado enfoque de la educación ambiental que tome en cuenta lejanas concepciones educativas y los nuevos postulados de la práctica docente en Costa Rica. Para explicar tales procesos, se emplean fuentes diversas y se describen, a grandes rasgos, las técnicas desarrollas en el curso. En tal sentido, desde la experiencia investigativa histórica y la práctica docente, este artículo subraya la trascendencia de nuevas formas de enseñar.
Sus cuerpos, nuestras vidas: torso desnudo y mandil en la historia mixteca de la costa
Authors: Gómez-Montes Liliana María
Published: January 2017

En la región costera de Oaxaca, en México, hay diversos pueblos mixtecos que nos cuentan algo de su historia a través de sus formas de vestir. Hoy en día podemos encontrar en algunas de sus comunidades que las mujeres usan su pozahuanco (falda de algodón local, a rayas). Unas llevan el torso desnudo, otras lo han cubierto con un mandil de tela de algodón industrial. A través de entrevistas con las mujeres mayores del lugar he ido reconstruyendo su memoria colectiva acerca del proceso de taparse el torso con el mandil. ¿Cómo, cuándo, por qué, quiénes fueron los primeros en llegar a mediados del siglo XX generando evidentes cambios en las formas de expresar su vestir y su desnudez? Haré una lectura historiográfica acerca del proceso de cambio en sus expresiones corporales.
El Holocausto consumado. Los crímenes de guerra nazis percibidos desde otros lejanos tilos . El Proceso de Nüremberg y los procedimientos de juzgamiento en Dachau según el diario El Día de La Plata (1945-1948
Authors: Bisso Andrés
Published: January 2017

El presente artículo indaga en las formas mediante las que el diario El Día de la ciudad de La Plata (Argentina) reprodujo, analizó y comentó, en la posguerra temprana, diversas instancias de juzgamiento a criminales de guerra nazis. Para ello se han tenido en cuenta tanto los editoriales acerca de la dimensión específica de dichos juzgamientos como la forma, cantidad y dinámica de reproducción de noticias emergentes de las agencias internacionales. Por último, se analiza el impacto que dichas noticias podían tener en la política nacional y estrictamente local, y la interpretación que de él realizaba el diario escogido para ser analizado.
The Seven-arm Octopus, Haliphron atlanticus Streenstrup, 1861 (Cephalopoda, Alloposidae), in the Fernando de Noronha archipelago, Brazil
Authors: Lima Françoise D. , Mendes Liana F. , Veras Leonardo , Leite Tatiana S. , Lima Sergio M. Q.
Published: January 2017

The rare deep-sea octopus, Haliphron atlanticus is the only known species recognized within the genus. A fragment of H. atlanticus was found in the Fernando de Noronha archipelago, Brazil (South Atlantic). Both phylogenetic reconstruction and pairwise genetic divergence show that the specimen recorded in South Atlantic is closely related to individuals from North Pacific. However, there is a greater divergence among these specimens and a giant octopus from North Atlantic. This evidence suggests that Haliphron is not monospecific, with at least two species, both represented in the Atlantic Ocean.
KARAKTERISASI FENOTIPE DAN GENOTIPE TIGA POPULASI IKAN TENGADAK (Barbonymus schwanenfeldii)
Authors: Kusmini Irin Iriana , Gustiano Rudhy , Radona Deni , Prakoso Vitas Atmadi , Putri Fera Permata , Prihadi Tri Heru
Published: January 2017

Ikan tengadak, Barbonymus schwanenfeldii merupakan salah satu jenis ikan lokal yang potensial untuk dikembangkan. Kemungkinan keberhasilan pengembangan ikan ini sangat tinggi karena ikan tengadak sekerabat dengan ikan tawes. Studi keragaman genetik dilakukan dalam upaya pemanfaatan sumber daya genetik untuk kegiatan budidaya secara berkelanjutan. Tujuan penelitian ini adalah untuk menganalisis keragaman dan kekerabatan antara populasi ikan tengadak asal Jawa, Sumatera, dan Kalimantan. Analisis fenotipe dilakukan berdasarkan pengukuran truss-morfometrik, sedangkan analisis genotipe dilakukan secara molekuler menggunakan metode PCR-RAPD dengan primer OPA-08, OPA-09, dan OPC-02. Hasil analisis fungsi kanonikal truss-morfometrik menunjukkan sebaran pengukuran ketiga populasi berada pada kuadran yang berbeda dengan persentase indeks keseragaman tertinggi pada populasi Sumatera dan Jawa (100%). Analisis genotipe menunjukkan ikan tengadak populasi Kalimantan memiliki nilai polimorfisme (50,00) dan heterozigositas tertinggi (0,206); secara kekerabatan ikan tengadak Kalimantan memiliki jarak yang jauh dengan ikan tengadak Jawa dan Sumatera.Tinfoil barb Barbonymus schwanenfeldii is one of potential local fish species for aquaculture development. The successful probability of aquaculture development of tinfoil barb is very high due to close genetic relationship with silver barb. Study related to genetic diversity was conducted in order to explore genetic resources for sustainable aquaculture. The aim of this study was to analyze the genetic diversity and relationship between tinfoil barb populations from Java, Sumatra, and Kalimantan. Phenotype analysis was conducted by truss morphometric, whereas genotype analysis conducted by PCR-RAPD using OPA-08, OPA-09, and OPC-02 primers. The results of canonical correlation analysis from truss-morphometric measurements showed that the distribution of three populations were located in different quadrants with the highest similarity index percentage on Sumatra and Java population (100%). Genotypic analysis showed that tinfoil barb population from Kalimantan revealed the highest value of polymorphism (50.00) and heterozygosity (0.206), Kalimantan population have distantly genetic relationship to tinfoil barb from Java and Sumatra.
Synthesis of TiNi by a green method
Authors: Reyes Luis , Valdez Jesús , Cavazos José Luis , Gómez Idalia
Published: January 2017

A green method for the synthesis of titanium–nickel (TiNi) using Penicillium sp. fungus as a bioreactor and its comparison with the titanium–nickel synthesis produced by l-cysteine as a reducing agent are reported. In this work, the authors show that Penicillium sp. in contact with titanium (Ti) and nickel (Ni) salt solutions produces a nanocomposite material: titanium–nickel/titanium dioxide (TiO2). The experimental procedure was carried out at room temperature. The concentrations of the solutions used for both metal ions were 2·54 × 10−4 M. The analysis by ultraviolet–visible showed the characteristic bandgap absorption for titanium dioxide at 250 nm, and the X-ray powder diffraction analysis showed the phase reflections of titanium–nickel alloy and titanium dioxide. In order to propose a route for the biosynthesis using the fungus, titanium–nickel was synthesised using l-cysteine as a reducing agent at 25°C. Analysis by field emission scanning electron microscopy and energy-dispersive X-ray spectroscopy shows agglomerates of nanosized particles corresponding to nickel and titanium metals. The use of l-cysteine and heat treatment at 250°C after the contact between l-cysteine and the ion salts in aqueous solution allow the easy synthesis of titanium–nickel. These processes represent new routes for the synthesis of titanium–nickel alloy under a non-exhaustive reaction.
Disproving bottom-up fatigue cracking in well-constructed asphalt pavements
Authors: Hunter Robert N.
Published: January 2017

Traditionally, asphalt pavements are believed to fail structurally in one of two ways, either deformation resulting from subgrade failure or bottom-up fatigue cracking. However, after many years of diagnosing the cause of a wide range of pavement failures, the author has yet to see that a well-constructed asphalt pavement over 150 mm thick has failed through bottom-up fatigue cracking. This paper reports on research to consider whether bottom-up fatigue cracking actually occurs in practice. The research involved examining traditional failure modes, considering methods for calculating base strain in flexible pavements and comparing the values, examining the concept of fatigue endurance limit, contemplating the types of deformation and looking at how pressure dissipates in typical asphalt pavements. The conclusion drawn is that bottom-up fatigue cracking does not occur in well-constructed asphalt pavements of even moderate thickness.
Las mediaciones. El paradigma y las metodologías que han innovado los estudios sociológicos y humanísticos
Authors: Chasqui Revista
Published: January 2017

Manuel Martín Serrano, como es sabido, es el creador del paradigma de las Mediaciones. Lo presentó por primera vez en francés, en su tesis de Doctorado de Estado, "L'Ordre du Monde a travers la T.V. Structure du discours électronique", leída en l'Université Louis Pasteur de Strasbourg, en 1974. "El paradigma de las mediaciones es un desarrollo teórico y metodológico para trabajar en ese nivel del ajuste, en el que informar, conformar y transformar son procesos interdependientes" La difusión al público de habla hispana, se hizo en el libro La mediación social, cuya primera edición se demoró hasta 1977 porque las autorizaciones administrativas para su publicación no se concedieron hasta ese año. El profesor Miquel de Moragas nos recuerda que, en esos años, convertir los procesos de mediación social en objeto de estudio sociológico era una absoluta innovación.
CIESPAL: Nueva etapa de TV
Authors: Proaño Luis Eladio
Published: January 2017

Información sobre el nuevo set de televisión de CIESPAL
ESTRATEGIAS DE RESOLUCIÓN DE CONFLICTOS EN LA PAREJA: NEGOCIANDO EN LO COTIDIANO
Authors: Correa Rodríguez Nieves , Rodríguez Hernández Juan A.
Published: January 2017

Abstract.STRATEGIES FOR CONFLICT RESOLUTION IN COUPLES: EVERYDAY NEGOTIATINGConflicts are normal situations in family life wich offer opportunities for personal growth and strengthening family relationships when constructive strategies are provided like negotiation, commitments and agreements. The frequent use of destructive strategies in everyday conflicts is associated with a growing unease in the family and a discontinuity in the family project. Couples show difficulties to implement courses of action culminating in agreements and commitments. This is a logical issue considering that the conflicts and the resolution strategies are complex situations. This work provides an analysis of daily conflict in couples contemplating conflict variables that mediate the use of resolution strategies and transactional processes that characterize these episodes. Finally, some guidelines are suggested to direct research and intervention in the field of conflict and family life.Keywords: Marital Conflict; Conflict Resolution Strategies; Negotiation; Situational Variables; Emotional Variables; Cognitive Variables.Resumen.Los conflictos son situaciones normales en la vida familiar. Suponen oportunidades para el crecimiento personal y el fortalecimiento de las relaciones familiares, siempre que se aborden con estrategias constructivas en las que prime la negociación, los compromisos y los acuerdos. El empleo frecuente de estrategias destructivas en los conflictos cotidianos se asocia a un creciente malestar en la familia poniendo en peligro la continuidad del proyecto familiar. Las parejas muestran dificultades para poner en marcha cursos de acción que culminen en acuerdos y compromisos. Lo que resulta comprensible si consideramos que los conflictos y las estrategias de resolución son situaciones complejas. Este trabajo ofrece un análisis del conflicto cotidiano en la pareja los conflictos contemplando las variables que mediatizan el uso de las estrategias de resolución y los procesos transaccionales que caracterizan estos episodios. Finalmente, se sugieren ciertas orientaciones para encauzar la investigación e intervención en el campo de los conflictos y la convivencia familiar.Palabras clave: Conflicto Marital; Estrategias de Resolución de Conflictos; Negociación; Variables emocionales; Variables Cognitivas, Variables Situacionales.
AGING OF THE HOMOSEXUAL INDIVIDUAL: TRAINING PROPOSAL FOR CAREGIVERS
Authors: Mónica dos Santos Carmina da Conceiçao , Santos Mendes Monico Lisete
Published: January 2017

Abstract.In current times, issues about sexual minorities are increasingly debated. Nonetheless, research about aging homosexuals is scarce, which reveals how neglected this subject is and how pressing it is to address it. Prejudice in contemporary society is felt by elderly homosexuals, who are aware that they are being discriminated against, something that has violent consequences and induces fear and anxiety about being outspoken about their sexual orientation. Thus, elderly homosexuals have a difficult time feeling free and fulfilled, which is damaging to their aging process. This paper intends to present a training proposal aimed at professional care providers of elderly homosexuals in institutions. It is urgent to conceive social responses that follow a multidisciplinary approach and that institutions would adopt with regard to their homosexual population.Key-words: Aging; Homosexuality; Caregivers; Institutional responsesResumo.Na atualidade, as questões sobre as minorias sexuais são cada vez mais discutidas. No entanto, há um grande défice na investigação acerca do envelhecimento da população homossexual, o que revela a negligiência com que o tema está a ser tratado e a urgência em ser abordado. A existência de preconceitos da sociedade contemporânea leva a que o idoso homossexual sinta a discriminação com que é tratado, reflectindo-se de uma forma violenta num sentimento de medo e angústia em manifestar a sua orientação sexual. O idoso homossexual vê-se desta forma impedido de ser livre, plena e integralmente, o que prejudica o seu processo de envelhecimento. O presente artigo pretende dar a conhecer uma proposta de formação ao nível de cuidadores formais de idosos homossexuais institucionalizados. Urge pensar de forma transdiciplinar nas respostas sociais que as instituições devem adoptar face à sua população homossexual.Palavras-chave: envelhecimento, homossexualidade, cuidadores, respostas institucionais
LAS ALUMNAS UNIVERSITARIAS: MODELO DE RESILIENCIA
Authors: Vera Gil Sara
Published: January 2017

Abstract.Educational reports in recent years have been warning a progressive increase of women in college. Universities today are widely feminized in most degree programs. A historical approach to women´s education tell us that this situation previous mentioned is a significant achievement for this group, especially because from their official access to education women have had to overcome serious difficulties. These difficulties which come from both institutional barriers and the limitations of gender roles and stereotypes, seem to have been overcome by women not only in a quantitative way but also in a qualitative because they have a higher academic performance than their male peers, those for which the education system was created . These difficulties from both institutional barriers and the limitations of gender roles and stereotypes have been overcome not only a quantitative but also qualitative, which seems to indicate the presence of resilient behaviors among students, behaviors that relate to successful coping with the adversities of the environment, leaving them empowered and ready to face new challenges.Keywords: resilience, college women, academic performance, resistance to difficulties, adaptation.Resumen.Los informes educativos de los últimos años vienen advirtiendo un aumento progresivo de las mujeres en los estudios universitarios. Las Universidades a día de hoy se encuentran ampliamente feminizadas en la mayoría de titulaciones. Acercándonos a la historia de la educación de las mujeres, lo anteriormente señalado supone un importante logro para este colectivo, ya que, desde su acceso oficial al sistema educativo, han debido sortear serias dificultades. Estas dificultades provenientes tanto de barreras institucionales como de las limitaciones de los roles y estereotipos de género han sido superadas no sólo de una forma cuantitativa sino también cualitativamente, lo que parece apuntar a la presencia de comportamientos resilientes entre las estudiantes, comportamientos que se relacionan con el afrontamiento exitoso de las adversidades del entorno, saliendo fortalecidas de ellas y preparadas para enfrentarse a nuevos retos.Palabras clave: resiliencia, mujeres universitarias, rendimiento académico, resistencia a las dificultades, adaptación.