bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS NILAI-NILAI KEPEMIMPINAN DI SMA ISLAM CIKAL HARAPAN 1 BSD
Authors: Yuwono Teguh , Rovita Angga , Riyana H Diana
Published: September 2019

Tujuan penelitian ini adalah untuk mengetahui nilai-nilai kepemimpinan di SMA Islam Cikal Harapan 1 BSD dan Bagaimana nilai-nilai kepemimpinan diterapkan.Metode penelitian yang digunakan adalah kualitatif, yaitu dengan cara melakukan wawancara dengan first hand information, Dari hasil wawancara dengan Kepala Sekolah SMA Islam Cikal Harapan 1 BSD ditemukan adanya nilai-nilai kepemimpinan yang  mendasarkkan pada kebijakan yayasan yang menanungi sekolah tersebut, sehingga kepemimpinan berdasarkan struktur. Dari Fokus Grup Diskusi ditemukan adanya nilai-nilai kepemimpinan yang diharapkan dapat menumbuhkembangkan etos kerja para guru dan  karyawan, sehingga diharapkan terbentuknya  nilai-nilai kepemimpinan yang memberdayakan antara pimpinan dan bawahan ( kepala sekolah dan jajaran guru serta siswa), maka diharapkan adanya sistem atau aturan yang menjadi dasar dalam menjalankan kepemimpinan. Adanya kesenjangan pemahaman nilai-nilai kepemimpinan dari hasil wawancara dan Fokus Grup Diskusi tersebut menimbulkan tantangan untuk dijawab, maka peneliti memberikan perspektif atau pandangan yang menyatukan dua sudut pandang ( pimpinan/kepala sekolah dan bawahan/guru dan siswa).
PENGARUH KOMPENSASI DAN MOTIVASI KERJA TERHADAP KINERJA KARYAWAN (Studi Kasus di PT. Lautan Otsuka Chemical)
Authors: Murtiyoko Heri
Published: September 2019

Tujuan penelitian ini untuk mengetahui seberapa besar pengaruh kompensasi dan motivasi kerja terhadap kinerja karyawan pada PT. Lautan Otsuka Chemical, Jakarta. Jenis penelitian merupakan penelitian kuantitatif dianalisis menggunakan statistik. Adapun  jumlah  sampel  yang digunakan sebanyak 154 responden. Analisis data menggunakan SPSS Versi 19. Teknik uji sampling menggunakan metode random sampling dan teknik pengambilan data diantaranya uji validitas, uji reliabilitas, uji asumsi klasik dan uji regresi linear berganda serta uji hipotesis. Hasil penelitian menunjukan bahwa kompensasi memiliki pengaruh sebesar 16,8% terhadap kinerja karyawan dan motivasi kerja memiliki pengaruh sebesar 3,2% sedang pengaruh secara simultan kompensasi dan motivasi kerja terhadap kinerja karyawan sebesar 16,8%
ANALISIS KINERJA KEUANGAN PERUSAHAAN MANUFAKTUR SERTA PENGARUHNYA TERHADAP HARGA SAHAM
Authors: Satiaputra Buchari E
Published: September 2019

Tujuan dari penelitian ini adalah untuk menganalisis apakah kinerja keuangan utama perusahaan yaitu WCTA, RETA, ROI, BVETL dan TATO, sampel adalah 15 perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia. Metode yang digunakan dalam penelitian ini yaitu analisis regresi berganda, analisis korelasi (PPM), asumsi klasik, uji hipotesis menggunakan adjusted koefisien determinasi, uji-F dan uji-t.Hasil pengujian menunjukkan bahwa variabel dependen (harga saham) dapat dipengaruhi oleh WCTA, RETA, ROI, BVETL dan TATO sebesar 11,35%. Nilai rasio keuangan yang diperoleh masih jauh di bawah standar industri untuk menunjukkan kinerja keuangan masih belum optimal dan efisien. Dari hasil regresi berganda variabel independen yaitu WCTA, RETA, ROI dan TATO memiliki korelasi positif terhadap harga saham, kecuali BVETL memiliki pengaruh negatif, dari perhitungan analisis korelasi terhadap WCTA, RETA, BVETL dan TATO memiliki dampak yang sangat rendah.
PENGARUH PERUBAHAN LOGO (REBRANDING) TERHADAP CITRA PERUSAHAAN PADA PT BANK BRI TBk
Authors: Nabila Nuzul Inas
Published: September 2019

Penelitian ini bertujuan untuk mengetahui pengaruh perubahan logo (rebranding) terhadap citra perusahaan yang dilakukan oleh PT Bank BRI Tbk. Hipotesis dalam penelitian ini adalah Perubahan logo PT Bank BRI Tbk berpengaruh terhadap citra perusahaan. Data diperoleh dari penyebaran kuesioner dengan metode non probability sampling dengan teknik purposive sampling. Sampel yang diambil 100 responden nasabah Bank BRI . Alat analisis yang digunakan yaitu regresi sederhana. Hasil analisis data diperoleh pengaruh perubahan logo terhadap citra merek sebesar r² = 0,342. Hal ini berarti sumbangan variabel x (perubahan logo) berperan dalam mempengaruhi setiap penambahan variabel y (citra perusahaan) sebesar 34,2%. Hal ini menunjukkan bahwa perubahan logo PT Bank Rakyat Indonesia (BRI) memberi pengaruh 34,2% terhadap citra perusahaan. Pengujian Hipotesis menunjukan bahwa thitung  lebih besar dari ttabel yaitu  7,136>1.984  artinya perubahan logo (rebranding) berpengaruh secara signifikan terhadap citra perusahaan pada PT Bank Rakyat Indonesia (BRI) Tbk.
ROLE OF ANTIDEPRESSANTS IN AMENDING THE CHEMICAL DISPARITY OF NEUROTRANSMITTERS IN PSYCHOSOMATIC DISORDERS.
Authors: Agarwal Mugdha , Agarwal Shriya , Agarwal Vinayak , . Rachana , Singh Manisha
Published: September 2019

This review summarizes the most common types of psychosomatic disorders including various types of depression based on their evolution, causes, symptoms and severity. The cellular and molecular mechanism behind the same in the areas of the brain, which are most susceptible to damage, both structurally and functionally (amygdala, the prefrontal cortex and the hippocampus) were keenly looked in to. Further, the therapeutic intervention through antidepressants was also been explored along with its three major categories in which they have been divided, their types, properties and mechanism of actions, especially towards the regulation of neurotransmitters in the brain has been highlighted. The behaviour of neurotransmitters in the presence of particular antidepressants is of grave importance in order to design an effective antidepressant drug, which could beat currently ineffective ones in the market and their potential forms have been studied and described. This review also provides an insight about the different approaches used for diagnosis using different types of biomarkers.
A PROSPECTIVE STUDY ON DRUG UTILIZATION IN OBSTETRIC PROCEDURES WITH EMPHASIS ON ANTIBIOTIC USAGE AT A TERTIARY CARE HOSPITAL
Authors: Sachdeva Shikha , Chaudhary Aarti , Nain Parminder , Santpur Unmesh
Published: September 2019

Background: Antibiotics are largely prescribed drugs in all major surgical procedures due to high prevalence of infections that has been increase in expenditure and increases antibacterial resistance. Drug utilization studies help to identify and overcome the misuse of antibacterial in prescribing pattern. Hence, the aim of this study was to evaluate the antibiotics utilization patterns in obstetric procedures.

Methods:  It is a prospective observational study carried out in department of obstetrics and gynecology, of a multi-specialty teaching hospital (Haryana) after obtaining permission from the IEC. The prescriptions were assessed for patient’s demographic data, antimicrobial preference, dose, duration, and route of administration. Categorization of drugs according to Food and Drug Administration (FDA), and rationality score as per the World Health Organization (WHO).

Results: During six month study period 120 patients were included into study. The mean age of women undergoing C-section procedure was 27.79±2.78 years. The maximum (90.83%) length of hospital stay was 2 week by women under C-section procedure. The single antibiotic therapy (ceftriaxone - 53.33%) was the most commonly prescribed antibiotic as prophylaxis but in post- operative prescription orders, triple antibiotic combination therapy (ceftriaxone, metronidazole with gentamycin) was maximum (62.50%) prescribed antibiotic. Parenteral route (96.09% in pre-operative and 59.40% in post-operative) was most common route for antibiotic administration. Out of 2216 drugs, branded drugs were 1893 (85.42%) and generic drugs were 323 (14.58%).

Conclusion: The present study facilitates the rational use of ceftriaxone as prophylaxis in C-section and triple antibiotic combination therapy as post-operative by the gynaecologists. These antibiotics are most effective without any adverse effect on mother and fetus when use in recommended dose and frequency during obstetric procedures.

Keywords: Antibiotics, Caesarean section delivery, Drug utilization study
Volatility and Transmission of Shallot Commodity Prices in Indonesia
Authors: Artika Kholifatin , Firdaus Muhammad , Irawan Tony
Published: September 2019

The shallot commodity has been becoming a strategic issue for the government nowadays because this commodity has contributed to inflation. The price volatility of shallots causes high price disparities between producers and consumers. This situation gives is detrimental more to farmers and consumers than to traders because it provides more opportunities for traders to manipulate information on price, so that price transmission becomes asymmetric. This paper discusses the price transmission of shallots between three players: farmers, wholesalers and retailers. This study used daily data from January 1st 2017 to December 31st 2017 which were analyzed using the ECM-EG method. The wald test results show that shallots commodities showed a price asymmetry in the short term in each marketing chain, namely between producers to wholesalers, wholesalers to retail and retail to producers. Whereas in the long run, the price asymmetry only exist on the wholesale-retail linkage. Meanwhile the transmission of long-term prices between producers to wholesalers, retail to producers in the long-term is symmetrical.
Decentralized Access Control with Anonymous Authentication of Data Stored in Clouds
Authors: Sathyabama Mrs. B. , SureshKumar C. , Kesau K. , Karthikeyan R.
Published: September 2019

The paper proposes a new decentralized access control scheme for secure data storage in clouds that supports anonymous authentication. In the proposed scheme, the cloud verifies the authenticity of the series without knowing the user's identity before storing data. Our scheme also has the added feature of access control in which only valid users are able to decrypt the stored information. The scheme prevents replay attacks and supports creation, modification, and reading data stored in the cloud. We also address user revocation. Moreover, our authentication and access control scheme are decentralized and robust, unlike other access control schemes designed for clouds which are centralized. The communication, computation, and storage overheads are comparable to centralized approaches.
Ethical Issues and Palliative Care in Advanced Breast Cancer Patients
Authors: Tahmasebi Mamak
Published: September 2019

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Hormone Replacement Therapy and Breast Diseases: A Matter of Concern for the Gynecologist
Authors: Eskandari Amirhossein , Alipour Sadaf
Published: September 2019

Background: The carcinogenic effect of exogenous steroid hormones on the breasts is a matter of debate, causing confusion for physicians at the time of making prescriptions. This article, as part of a quadruple series about exogenous sex hormones and breast disorders, reviews the association of breast cancer and hormone replacement therapy (HRT) in the general population, women with benign breast disorders, women with personal or family history of breast cancer, and BRCA carriers. Methods: We accomplished an extensive search of the literature by using relevant keywords to identify pertinent cohort studies, clinical trials, and reviews. Then, we extracted all points regarding the question. Results: An extensive literature exists on the risk of breast cancer following HRT in the general population, and HRT has been mentioned as a risk factor for breast cancer, especially in recent, long-term users of combined formulations. However, there is still no consensus about it. Conversely, few studies have considered challenging issues like the use of HRT in breast cancer survivors and high-risk women. Conclusion: HRT up to 5 years can safely be used for management of menopausal symptoms in healthy women, and those with low-risk benign breast disorders. On the contrary, its use in high-risk women should be limited to refractory menopausal symptoms after describing potential harms to the patient.
Systemic Therapy in Local Recurrence of Breast Cancer, Report of a case and Decision Making in MDT Meeting
Authors: Deban Melina , Younan Rami , Charpentier Danielle , Yelle Louise , Tran-Thanh Danh , Patocskai Erica
Published: September 2019

Background: Locoregional recurrence of breast cancer has significantly decreased over the last decades, particularly due to effective systemic therapy. While there is little controversy regarding local management of locoregional recurrences, in light of previous systemic treatment, additional chemotherapy regimens and their benefit to the patient are still subject to debate in tumors boards.Case Presentation: A 45-year-old woman was referred to our tertiary care center with a local recurrence of breast cancer 9 years after modified radical mastectomy for a ypT2N2a invasive ductal carcinoma. She received neoadjuvant treatment consisting of FEC-D (5-FU-epirubicin-cyclophosphamide, followed by docetaxel) for hormone receptor positive, HER-2-neu negative cancer in 2009, as well as adjuvant radiotherapy and tamoxifen for 9 years. After R0 resection of the hormone receptor positive, HER-2-neu negative recurrence in 2019, adjuvant therapy with ovarian suppression and an aromatase inhibitor was undertaken. A multigene assay identified a recurrence score at 37 and benefit from chemotherapy > 15%.Question: What would the ideal chemotherapy regimen consist of for this patient with an R0 resection of late recurrence of breast cancer?Conclusion: After reviewing history, imaging and pathology, members of the multidisciplinary team recommended treatment with Taxotere and cyclophosphamide (TC) x 4 for our patient.
Breast Cancer Patients' Preferences When Receiving Bad News: A Qualitative Study from a Middle Eastern Country
Authors: BorjAlilu Somayyeh , Karbakhsh Mojgan , Davoodzadeh Kamelia , Tak Maryam , Amani Nazila , Kaviani Ahmad
Published: September 2019

Background: Telling bad news to the patients after a diagnosis of breast cancer is one of the most important duties of a physician. The aim of this study was to explore breast cancer patient's preferences regarding how to receive bad news. Methods: A group of 15 women with breast cancer were purposively recruited to this qualitative study. Semi-structured in-depth interviews were conducted to identify the patients' preferences through content analysis. Results: The age of participants ranged between 28 and 58 years. Nine patients had undergone mastectomy and the remaining 6 had received conservative surgery. The minimum time between the diagnosis and receiving the news of cancer was 1 month, the maximum 15. Altogether, 250 codes were extracted after content analysis and categorized into 7 categories and 43 subcategories. The main categories were the method of disclosure of bad news, medical information, communication skills, emotional support, family involvement, the setting, psycho-spiritual care, and the word “cancer.” Conclusion: Knowing about patients' preferences regarding the methods of breast cancer diagnosis disclosure can help physicians to effectively deliver bad news. Therefore, it is necessary that the clinicians be informed about the themes that the patients consider important while delivering bad news to patients.
Management of Carcinoma of Unknown Primary Involving Axillary Lymph Node (CUPAx)
Authors: Omranipour Ramesh , Eslami Bita , Najafi Masoume , Mahmoudzadeh Habibollah , Vasigh Mahtab , Elahi Ahmad
Published: September 2019

Background: Cancer of unknown primary involving axillary lymph nodes (CUPAx) is a very rare type of cancer. There are still many challenges about the management and outcome of the disease. This retrospective study is an attempt to assess the overall survival and the outcome of CUPAx in Iranian women. Methods: Based on inclusion and exclusion criteria, 20 patients primarily diagnosed with CUPAx referred to our breast multidisciplinary team (MDT) sessions between July 2010 and December 2016 were evaluated. The patients were categorized into three groups based on the types of treatment: mastectomy and radiation therapy, radiation therapy, and observation group. Results: The mean age of the subjects was 52 ± 7.91 years (range: 42-74). The results manifested significant differences between the outcomes of three types of treatments. The patients who received both mastectomy and radiotherapy had a higher survival rate and no sign of the disease compared with other groups (P= 0.03). The median survival time in the mastectomy group was 78 months and 23 months for the group with no mastectomy (95% CI: 7.64-38.36) (P <0.001).Conclusion: The result suggested that mastectomy was effective in lowering the risk of disease progression in Iranian women diagnosed with CUPAx and highly suspicious breast origin. More studies on larger sample groups are needed.
Cross Oncoplastic Breast Surgery Technique; A Good Choice for Tumors Located Far From Nipple Areola Complex
Authors: Kaviani Ahmad , Ashraf-Ganjouei Amir , Zand Sanaz , Elahi Ahmad , Vasigh Mahtab , Ahmadi Hamid , Kord Zanganeh Marzieh , Rahmani Samira , Salmon Remy
Published: September 2019

Background: Although various Oncoplastic Breast Surgery (OBS) techniques have been introduced for varied sizes of the breast and locations of tumors , surgeons are still faced with serious challenges for tumors which have developed in special anatomic part of the breast. A good instance of these challenges is the tumors located far from Nipple Areola Complex (NAC) especially in the upper inner quadrant. We aimed to assess the application of newly introduced OBS technique (Cross Technique) in these situations. Methods: The data of 95 patients who suffered from breast cancer and operated with Cross method were assessed in this prospective survey. Data was gathered regarding demographic variables, the size, location, and pathologic characteristics of tumors, patients' BMI and breast circumference and cup size. The patients were recruited to the study according to inclusion and exclusion criteria and the study protocol which was approved by the research deputy of department of surgery, Tehran University of Medical Sciences. Data was presented in a descriptive method.Results: Nighty-five patients underwent oncoplastic breast surgery using the Cross method from November 2015 to May 2018. Patients had a mean age of 48.2 ranging from 25 to 70 years. The patients had a wide range of breast circumference and cup size (70 to 95 for the breast circumference and A to E for the cup size). Clear surgical margin was obtained in 93 cases according to the permanent pathology reports. The complications were seen in 5 patients all managed conservatively (2 slight hematoma and three ischemic skin flaps). The most common histologic type was insitu and invasive ductal carcinoma (DCIS-IDC). Mean tumor size was 22.7 mm with standard deviation of 9.2mm, most of which were positive for estrogen receptor (ER)/progesterone receptor (PR). As the surgery of axilla, six lymph nodes were excised on average and 22 patients had axillary lymph node involvement.Conclusion: The Cross method is not only a reliable choice for tumors located in the UIQ, but it can also be applied safely for tumors in UOQ and upper central part of the breast, although the best application for the technique is the tumors located far from nipple areola complex.
Contralateral Breast Diffuse Large B Cell Malignant Lymphoma With Previous MALT Lymphoma
Authors: Assarian Ali , Ebarhimi Amirpasha
Published: September 2019

Background: Breast involvement during malignant lymphomas is a rare condition, whether in primary or secondary cases, whereas according to the literature, primary breast lymphomas represents merely less than 0.5% of the breast malignancies.Case Presentation: The case was a 48 years-old patient referred to the clinic with contralateral breast diffuse large B cell malignant lymphoma. She had an operation for right breast mucosa-associated lymphoma tissue (MALT) lymphoma two-years earlier. The participant experienced surgical excision of the right breast mass and radiotherapy subsequently. Surprisingly, after two years she developed a mass on the left breast, for which we were not able to establish an evident relationship between the earlier MALT lymphoma and the second diffused B cell lymphoma.Conclusion: Although, our report emphasizes on the undeniable role of the breast examination in prevention of catastrophic events, we are far from providing diagnostic approaches on breast MALT lymphoma, due to minimal case sizes and lack of adequate information and evidences.
Isolation and Molecular Marker Detection of Badh2 Gene from Aromatic Rice Germplasm Resources in Southern Henan
Authors: Peng Bo , Zhu Yu , Wang Zi-Yu , Peng Juan , He Lu-Lu , Tian Xia-Yu , Liu Zi-Yue , Sun Ling , Wang Ying , Song Xiao-Hua , Li Hui-Long , Sun Yan-Yang , Pang Rui-Hua , Li Jin-Tao , Wang Quan-Xiu , Zhou Wei , Yuan Hong-Yu
Published: September 2019

The production of aroma in aromatic rice is due to the increase of 2-acetyl-1-pyrroline (2-AP) precursor substances caused by the functional deletion of Badh2 gene on chromosome 8, and the accumulation of 2AP makes rice produce aroma. In this study, Badh2 gene was isolated and cloned from 18 representative aromatic rice cultivars in Southern Henan, and the bioinformatics analysis of Badh2 gene was carried out. Meanwhile, seven functional molecular markers developed by Badh2 gene were used to detect and analyze Badh2 gene in 18 aromatic rice varieties from Southern Henan. The results showed that the coding region of Badh2 gene was 1509 bp in length. It contained 15 exons and 14 introns, and encoded 503 amino acids. There are many types of variation of the Badh2 gene in the 18 aromatic rice varieties. According to the variation of Badh2 gene, the tested aromatic rice varieties could be divided into three groups, among which Xinxianggeng 1, Xiangnuo 25, Heixiangdao 193 and Xiangbao 2 were concentrated in group Ⅰ, while the other 14 kinds of aromatic rice were concentrated in group II. Seven functional molecular markers of Badh2 gene were used to detect different varieties mutation types in exon 2, exon 4~5, exon 7 and exon 13 of Badh2 gene. No aromatic rice varieties with different mutation types were found in promoter region, exon 12 and exon 14 of Badh2 gene. Therefore, our results provide important information for understanding the genetic basis of fragrant genes in aromatic rice germplasm resources in Southern Henan and breeding new varieties of high-quality aromatic rice using molecular marker-assisted selection.
Determinantes da confiança do consumidor e dinâmica da política monetária no Brasil
Authors: Caetano Rafaela Maiara , Da Silva Cleomar Gomes
Published: September 2019

The aim of this article is to investigate the determinants of consumer confidence in Brazil and possible impacts on monetary policy actions. The econometric methodology applied is based on Autoregressive Distributed Lag (ARDL) Models, particularly the Bounds Testing (ARDL) Approach to Cointegration. For monthly data between January 2003 and December 2016, the empirical results suggest that there is a long run relationship between consumer confidence and the other variables analyzed. As for short-run dynamics, the error correction mechanism varies between 1.9% and 8.7%, depending on the estimated model. This suggests that economic variables influence consumer confidence, and when there is a break in confidence, its recovery is very slow.
Choques externos e desequilíbrios financeiros: uma interpretação sobre a crise brasileira
Authors: Kirsten Martin Branco , Morrone Henrique
Published: September 2019

This paper investigates the causes of the Brazilian recession that began in 2014. If, on the one hand, the conventional diagnosis attributes the crisis to a lack of control of public finances, other interpretations emphasize external shocks and excessive indebtedness of the private sector. The alternative hypothesis is that the deterioration of public accounts is a consequence of the crisis and not its cause. The methodology developed by Toda and Yamamoto (1995) is used to verify the hypothesis of non-causality of Granger between the time series of the balances of the private sector, public sector and current account, from the Central Bank of Brazil (BCB, 2017) for the 2002-2017 period. The results suggest that the balances of the external and private sectors cause in the Granger sense the balance (result) of the public sector.
The irrationality of Petrobras’ divestments in refining
Authors: Ribeiro Cássio Garcia , Silva Guilherme Jonas Costa da , Almeida Francielly De Fátima
Published: September 2019

Petrobras is a Brazilian state-owned company that is one of the largest oil companies in the world. It is internationally recognizedfor being a company at the technological frontier in the segment of exploration and production (E&P) of oil and gas in deepwaters. Also, Petrobras is the publicly traded oil company with the largestproduction of hydrocarbons in the world. This paper aims to investigate the strategies Petrobras currently adopts in refining based on an econometric analysis of panel data. The article is apioneer in the sense of empirically demonstrating that Petrobras consolidated its position in E&P while advancing in the aggregation of value in the refining sector. We can see that income elasticity are less than 1 (about 0.6%). Thisis positive and significant, but the smaller sensitivity than unity demonstrates that the country has broken the barrier to entry into the export sector of oil products.Thus, based on econometric estimates, it is believed that there is a great misunderstanding in the strategy of divestitures and downsizing in the segment of refining.
Microbiological substantiation of application of phytopreparations in treatment of inflammatory periodontal diseases
Authors: Abdurakhmanova S. A. , Runova G. S. , Podporin M. S. , Tsareva E. V. , Ippolitov E. V. , Tsarev V. N.
Published: September 2019

Relevance:Inﬂammatory-destructive periodontal diseases are the most complicated and became the main cause of tooth loss in adult population. Herbal medicines have a variety of pharmacological properties, so the development and introduction of new forms for the treatment of inﬂammatory periodontal diseases is an urgent task today.

Purpose– experimental evaluation of eﬀectiveness of the use of herbal medicines “Tonzinal” and “CM-1” in relation to the priority periodontal pathogenes.

Materials and methods:in experimental studies, the basis for the experiment was the system for the cultivation of microorganisms in real time – the Revers-Spinner RTS-1 bioreactor. With the priority strains of periodontitis pathogens, the study of the growth dynamics of the culture was carried out in several parallels.

Results:herbal medicines “CM-1” and “Tonsinal” has a multilateral therapeutic eﬀect, exerting a diverse inﬂuence on the key stages of development of such bacterial populations as Aggregatibacter actinomycetemcomitans, Streptococcus constellatus, Candida albicans.

Conclusion:tan integrated approach in the treatment of patients with inﬂammatory periodontal diseases is promising and will contribute to a more prolonged remission and increase the eﬀectiveness of treatment.
Study of the distribution of internal stresses in prototype dentures supported by isoelastic dental implants and teeth
Authors: Dubova L. V. , Zolkina Yu. S. , Tagiltsev D. I. , Majidova E. R.
Published: September 2019

Relevance: the aim of the research was to optimize the choice of material for fabrication of temporary dentures on isoelastic implants by ﬁnite element method.

Materials and methods: four models were constructed of supporting element (basal PEEK implant, crestal PEEK implant and natural tooth in diﬀerent combination) and in prototype dentures from three diﬀerent materials. Areas of the maximum voltage in constructions have been revealed and possible loads have been calculated by ﬁnal element method.

Results: the areas of maximum stress occur in the intraosseous part of implants in all studued cases.

Conclusions: analysis of the data shows that the stresses in crowns is practically independent of the properties of the studied temporary bridges materials. Models 1 and 3 were the strongest. Model 4 was less strong.
Evaluation of the effectiveness of the main systemic antibiotics at the first stage of treatment of generalized aggressive periodontitis
Authors: Zakirov T. V. , Voroshilina E. S. , Brusnitsyna E. V. , Ioshchenko E. S. , Ozhgikhina N. V.
Published: September 2019

Relevance: the aims of the study was to compare the eﬀectiveness of the use of various systemic antibiotics in patients with aggressive generalized periodontitis. A comparative study of systemic antibiotic therapy using modern molecular biological methods is important in modern periodontology.

Materials and methods: a prospective, randomized, controlled study of 112 patients with generalized aggressive periodontitis before and after using systemic antibiotics with real-time PCR (GE/ml) of major periodontal pathogens. The median was chosen as a quantitative measure of central tendency. Upper and lower quartiles were used for interval estimation.

Results: moxiﬂoxacin is most eﬀective against Porphyromonas gingivalis (median 102,1 GE/ml) and Tannerella forsythensis (median 103,7 GE/ml). Also eﬀective and reliably suppressed Porphyromonas gingivalis and Treponema denticola when lincomycin was used (medians 103,2, 102,7 GE/ml).

Conclusion: the most eﬀective systemic antibiotics are moxiﬂoxacin and lincomycin, which signiﬁcantly reduced the number of Porphyromonas gingivalis, Tannerella forsythensis, and Treponema denticola in periodontal pockets.
The effectiveness of complex conservative periodontal therapy using a gentle treatment technique by ultrasonic apparatus with calcium hydroxide polishing suspension among patients with type 1 diabetes and chronic generalized periodontitis
Authors: Orekhova L. Yu. , Loboda E. S. , Grinenko E. V. , Musaeva R. S.
Published: September 2019

Relevance: the presence of somatic disease is often the main and aggravating factor in development of chronic generalized periodontitis. Treatment of inflammatory periodontal diseases begins with mechanical removal of dental calculus and biofilm on a surface of the teeth. For this purpose along with traditional manual tools are applied sonic ultrasonic, and vibrascalers. Atraumatic and high efficiency of professional oral hygiene complex are extremely important for the treatment of periodontal disease in patients with diabetes. Purpose – to study the effectiveness of professional oral hygiene with use of the Vector apparatus in patients with type 1 diabetes. Materials and methods: this article presents study results of the effectiveness of the Vector ultrasound device use as part of therapeutic and preventive measures complex among 3 patients in different ages with generalized periodontitis and type 1 diabetes mellitus. We conducted a dental and X-ray examination and microbiological analysis of periodontal space contents. All patients underwent professional oral hygiene and Vector-therapy. Results were evaluated after 1 month. Results: using the example of 3 clinical cases, the effectiveness of professional oral hygiene complex was presented. After 4 weeks there were observed the reduction of patients complaints for bleeding gums when brushing teeth, improving hygienic and periodontal indices, reducing the composition and number of periodontal pathogens. Conclusion: treatment of inflammatory periodontal diseases using the Vector system is recommended as an early prevention of the development of a more severe periodontitis, as well as the most benign and minimally invasive treatment for periodontal diseases due to its high effectiveness.
Oral application of probiotics in the treatment of peri-implant mucositis
Authors: Ahmedbeyli C. R.
Published: September 2019

Relevance: to evaluate the clinical eﬀectiveness of probiotic as an adjunct to professionally administered plaque removal (PAPR) in the treatment of peri-implant mucositis.

Materials and methods: 42 patients with at least 2 implants with peri-implant mucositis and probing depth (PD) of 3-4 mm were selected and randomly divided into two groups. Test group received PAPR plus probiotic powder (Enteﬂavin® 4 g), whereas control group received PAPR only. Plaque index (PI), Gingival Index (GI), Bleeding on Probing (BoP), PD were measured at baseline and at days 21, 90, 180 and 360 after treatment.

Results: TEST and control groups involved 21 patients with 61 implants and 21 patients with 59 implants, respectively. All clinical parameters were improved in both groups. Inter-group diﬀerences for PI, GI, BoP & PD were found to be statistically signiﬁcant at all time periods after the treatment in favor of test group (p < 0.05).

Conclusion: PAPR alone or in combination with probiotic powder revealed clinical improvements in peri-implant mucositis patients. Better results were obtained with the adjunctive administration of probiotic. Probiotic therapy may be useful for the prevention and treatment of peri-implant mucositis.
Prophylaxis of inflammatory complications after an immediate dental implant surgery
Authors: Lepilin A. V. , Zakharova N. B. , Shalina M. Y. , Fishchev S. B. , Sevastyanov A. V.
Published: September 2019

Relevance: among the directions of modern medicine dental implantology is currently experiencing rapid development. To predict the long-term positive result of surgical treatment, it is important to study the content of Pro- and anti-inﬂammatory cytokines (IL-8, MCP-1, RAIL, TNF) in the gingival ﬂuid and the validity of the use of immunomodulatory drugs after the installation of dental implants.

Purpose – studying the features of changes in the immunoregulatory processes of the mouth cavity when using Imudon medication after dental implantation operation directly into the hole of the removed tooth.

Materials and methods: materials, received during the examination of 83 patients, were used for work (42 menand 41 women), with partial secondary adentia, ages 20 to 50, who were treated in dental clinics of “Medstom”, “Masterdent”, and “Tari” (Saratov city).

Results: received changes of pro inﬂammatory and anti-inﬂammatory levels of cytokines of the gingival sulcus in each examined group, with or without the use of Imudon medication, after implant installation, give the base to believe that after the operation in tissues, surrounding implants, form local changes of immunoregulatory processes.

Conclusion: the possibility of early postoperative complications after dental implantation directly into the hole of the removed tooth decreases when prescribing Imudon medication in the ﬁrst 10 days of the postoperative period.
Evaluation of efficiency of complex treatment of patients with generalized chronic parodontitis and bruxism
Authors: Khaybullina R. R. , Gerasimova L. P. , Kabirova M. F. , Rakhmatullina R. Z. , Tkachenko E. D. , Galetti K.
Published: September 2019

Relevance: the purpose of this work was to study the eﬀectiveness of proposed treatment and rehabilitation complex for patients with generalized chronic periodontitis and bruxism.

Materials and methods: we examined 73 patients aged 30 to 45 years diagnosed with generalized chronic periodontitis of moderate severity and bruxism. Control group included 15 healthy individuals of the same age for clarify normal functional parameters. Clinical, Doppler ﬂowmetry and electromyographic methods were used for evaluation of the eﬀectiveness of proposed treatment and rehabilitation complex.

Results: the course of treatment resulted in the increase in blood ﬂow perfusion volume by 37.7% (p < 0.05), of blood ﬂow perfusion rate by 58.2% (p<0.05) from baseline values. At the same time, the decrease in bioelectric activity of temporal muscle at rest by 51.82% (p >< 0.05), at voluntary contraction – by 40.4% (p<0.05), the decrease in bioelectric activity of masseter muscle at rest – by 47.4% (p><0.05), at voluntary contraction - by 35.12% (p >< 0.05) from values before treatment, were observed.

Conclusion: data obtained on the basis of electromyography and laser Doppler ﬂowmetry showed that developed treatment and rehabilitation complex is an eﬀective method for correcting the microcirculation in periodontal vessels and the functional activity of the muscles of maxillofacial area.
The role of odontogenic infection role as a medical justification of planning the individual prevention programs in childbearing age women
Authors: Ulitovskiy S. B. , Kalinina O. V. , Spiridonova A. A. , Domorad A. A.
Published: September 2019

Relevance:odontogenic infection plays an important role in the development of pregnancy complications, often causing premature birth of the child, as well as limiting its growth and development. According to studies Figueiredo C., Rosalem C., Cantanhede A. found that during pregnancy, women’s organs undergo various physiological, neurological and hormonal changes that occur gradually. In the process of such a restructuring of the body changes the dental status, which determines the correction stages of individual oral hygiene. According to the study Trigolos N. N., Firsova I. V., Makedonova Y. A. and others determined that dental health improves dental status, eliminates the possibility of exacerbation of chronic odontogenic foci of infection, reduces the risk of fetal infection and development of prenatal and postnatal complications, as well as a positive eﬀect on antenatal prevention of dental diseases of the child.

Materials and methods:a total of 216 pregnant women were examined and monitored for a month. To study the hygienic status of women during pregnancy with the pathology of hard tissues of teeth, the hygienic index of green-Vermillion was used. Assessment of the acid-base state of the oral ﬂuid was carried out using the pH meter of the company “Hanna” with a replaceable pH electrode HI 1270. Antimicrobial activity of the hygiene of the mouth was studied with the use of diﬀerent means of oral hygiene in the process of carrying out hygienic measures to identify maximum eﬃciency in the selection of funds and the development of “personal hygiene prevention programme”.

Results:the assessment showed an increase in the cleansing eﬀect for the entire period of the study in group 1 from 16.90 ± 3.53% to 49.77 ± 5.62%, in group 2 – from 28.19 ± 3.85% to 64.21 ± 6.32%, in contrast to the control – from 16.14 ± 3.21% to 35.87 ± 5.07%. Indicators of changes in acid-base eﬃciency of oral ﬂuid were in the 1st group 2.50 ± 0.20, in the 2nd group - 3.21 ± 0.20, and in the 3rd group was 2.38 ± 0.20.

Conclusion:during pregnancy, it is necessary to choose the right hygiene products to ensure oral health and maintain odontogenic infectious status, which eliminates the risk of preterm birth, which threatens a pregnant woman. The importance of odontogenic infection and ways of prevention in women of childbearing age is determined by the development of measures to strengthen dental health and plays a leading role in the planning of individual programs for the prevention of major dental diseases in women of childbearing age.
Dynamics of indicators of reparative regeneration of the oral mucosa in patients with lichen planus
Authors: Firsova I. V. , Poroiskiy S. V. , Makedonova Yu. A. , Fedotova Yu. M.
Published: September 2019

Relevance: red lichen planus refers to a long, protracted disease with a chronic course. There are a lot of root causes, it is quite diﬃcult to diﬀerentiate them. Therefore, pharmacotherapy of this pathology is reduced to the appointment of local drugs that have only symptomatic eﬀects that help accelerate the healing of the oral mucosa.

Purpose – to study reparative regeneration based on the analysis of clinical and cytological examination on the background of the appointment of various methods of pharmacotherapy.

Materials and methods: all patients were divided into two groups using simple randomization: in patients of the ﬁrst group, betamethasone B was used to treat erosive-ulcerative lesions, which were delivered to the lesion using Tisol, which has conductive transcutaneous activity, using the sandwich technique. The second group of patients used the drug delivery system in the form of a ﬁlm, which ﬁxed betamethasone B in the lesion area.

Results: were evaluated before treatment, on day 7 and 14. The area and intensity of healing of the oral mucosa were determined, a qualitative and quantitative analysis of cytograms was carried out, which characterizes the dynamics of reparative regeneration of erosions and ulcers.

Conclusion: based on the obtained clinical and laboratory data, it can be concluded that it is advisable to include betamethasone applications in the pharmacotherapy of patients with erosive and ulcerative forms of lichen planus. However, preference should be given to the method of layer-by-layer application of betamethasone B in combination with Tezol.
Hygienic assessment of the oral cavity in individuals with excess body mass index during orthopedic rehabilitation with removable dentures
Authors: Chesnokov V. A. , Chesnokova M. G. , Nesterova K. I. , Musienko A. I.
Published: September 2019

Relevance: the search for ways to improve the eﬃciency of dental orthopedic rehabilitation of patients with dentition defects is relevant. Most people with overweight and obesity over 45 years old with a high incidence of pathology in the form of partial absence of teeth. Reducing the eﬀectiveness of chewing, taking highly carbohydrate foods contribute to an increase in the growth of plaque, the intensity of the carious process and the deterioration of hygienic indicators of the mouth.

Purpose – to assess the hygienic condition of the oral cavity in patients with an excess of body mass index after orthopedic treatment with removable prostheses.

Materials and methods: the survey was conducted to 57 individuals with excess body mass index (BMI): overweight and obesity at various times after the manufacture of partial removable laminar dentures after 1 month, 3 and 6 months after prosthetics. The dental formula, dentition classiﬁcation in Kennedy’s modiﬁcation and mucosa according to Supple, the presence of periodontal diseases, dental indexes were determined by the simpliﬁed hygiene index of the oral cavity ОНJ-S (Oral Hygiene Index Simple) and the gingivitis index GI (Gingivitis Index).

Results: When using removable dentures, indicators of oral hygiene indices sharply deteriorated. After the ﬁrst month of wearing prostheses, the ONJ-S Green index increased by one third, after 3 months and 6 months, it worsened over the period of observation of patients. The Silnes–Low Index increased 1.5 times after a month of wearing a prosthesis, after 3 months – almost 2 times, after 6 months – 3.7 times, which corresponded to moderate gingivitis.

Conclusion: studies have shown that overweight, obese people using removable dentures after prosthetics showed a deterioration in the index indicators – OHJ-S and Silnes–Low in the dynamics during the observation period for patients.
Correction of antioxidant protection of the oral mucosa in chronic pancreatitis
Authors: Lavrovskaya Ya. A. , Romanenko I. G. , Lavrovskaya O. M.
Published: September 2019

Relevance:inﬂammatory processes in the oral mucosa are often found in diseases of the gastrointestinal tract, which is explained by the common functions and unity of all parts of the digestive system.

Purpose– to study the eﬀect of the studied drugs on the state of antioxidant-prooxidant systems of the oral mucosa in patients with chronic pancreatitis.

Materials and methods:we examined 118 patients, of whom 62 were men (mean age 39.6 ± 16.4 years) and 56 women (mean age 40.3 ± 15.7 years); of these, 34 patients (control group) are practically healthy people without somatic pathology and 84 patients with chronic pancreatitis who were divided into two groups. The ﬁrst (main) group - 46 people who, in addition to the drug therapy prescribed by the gastroenterologist, were prescribed the drug “Multiﬂora” 1 tablet 1 time per day with meals for 30 days. Also, the patients of the main group, after each meal, rinsed their mouths with “Enoant” food concentrate at a dilution of 1: 5 and applied it inside with 1 tablespoon 2 times a day, diluted with water in a ratio of 1: 5. The second (comparison group) - 38 people who, in addition to treatment of chronic pancreatitis, were treated with the oral mucosa according to the generally accepted method - prescribed ﬂuconazole 150 mg 1 time a day, rinsing with 2% borax solution in glycerol after eating for 14 days. Unstimulated oral ﬂuid of the examined patients served as the material for the study. In all groups, the activity of the catalase enzyme was determined by the method of S.V. Girina (1999), the level of malonic dialdehyde (MDA activity by reaction with thiobarbiturate acid to form a trimethine complex) and antioxidant-prooxidant index of unstimulated oral ﬂuid by the method of А.P. Levitsky (2010). Laboratory research was carried out at the time of the initial examination before the start and on the 30th day of treatment.

Results:in the comparison group after treatment, an increased concentration of malondialdehyde in the oral ﬂuid, as well as reduced indicators of the API index and catalase activity conﬁrm the presence of inﬂammatory processes in the oral mucosa. The application of the proposed therapeutic complex to patients of the main group signiﬁcantly reduces the concentration of malondialdehyde in the oral ﬂuid, proving its anti-inﬂammatory eﬀect on the oral mucosa. An increase in the antioxidant-prooxidant index and an increase in catalase activity indicates an increase in the body’s defenses in patients of the main group.

Conclusion:the use of the proposed therapeutic complex in patients with inﬂammatory diseases of the oral mucosa suﬀering from chronic pancreatitis contributes to the elimination of inﬂammatory and degenerative processes and the restoration of the normal level of protective systems in the oral mucosa.
Técnicas activas y su contribución al aprendizaje de la matemática en estudiantes de séptimo grado
Authors: Ojeda Ojeda José Jairo
Published: September 2019

La investigación fue desarrollada desde el enfoque cuantitativo, se apoyó en la tipología descriptiva, con el objetivo de Determinar la contribución de las técnicas activas en el aprendizaje de la matemática en los estudiantes del séptimo grado de la escuela de Educación General Básica Teniente Hugo Ortiz, período académico 2018-2019. La población de estudio, estuvo conformada por 32 son estudiantes del séptimo grado de Educación Básica de la escuela Teniente Hugo Ortiz, paralelo “A”, entre las principales conclusiones se tiene que las técnicas activas aplicadas al proceso de aprendizaje de la matemática, en especial en los estudiantes investigados en el subnivel medio de educación básica; les abre un mundo de múltiples oportunidades; pues son ellos quienes figuran como protagonistas de sus propios conocimientos, los cuales resuelven diferentes problemáticas, siempre y cuando desde sus ritmos y estilos de aprendizaje.