bluuebunny/crossref_metadata_2025 huggingface dataset:
Management Model Based on 5s and Systematic Layout Planning (SLP) to Improve the Level of Service in the Cleaning Sector
Authors:   Facultad de Ingeniería y Arquitectura, Universidad de Lima, Lima, Perú., Huamán-Torres Marco , Poma-Chavez Giannina , Quiroz-Flores Juan Carlos , Collao-Diaz Martin , Flores-Perez Alberto
Published: November 2023

In Peru, the cleaning sector has played an important role in recent days, allowing its continuous development. However, non-delivery of materials, whether due to quantity, delay or damage, is one of the most recurring problems in the sector. Therefore, the management in the storage of materials, to later distribute them to the units, plays an important role in the classification and collection of materials, the transfer without the need for reprocessing, optimizing the picking time, maintaining the durability of the material without damage and ensuring the care of the workers in the area. This study analyzes a warehouse of a cleaning company, which has problems in meeting the delivery time of materials due to the time it takes to pick them. The main causes are damaged materials due to incorrect picking, the delay in locating the material generated by the lack of knowledge of the materials, the disorder that occurs in the area, the lack of cleanliness in the area, and the inefficient distribution of the materials. which are located in different parts.
Characterization of the Fintech Industry for the Peruvian Market
Authors:   Universidad de Lima, Perú, Mejia-Trujillo Stefano , Hidalgo-Castilla Rafael Daniel , Ruiz-Ruiz Marcos Fernando , Flores-Perez Alberto , Quiroz-Flores Juan , Collao-Diaz Martin
Published: November 2023

Financial technology companies in Latin America and the world, typically known as Fintech, are growing at a significant rate. However, a detailed analysis on the main influencers on the success or survival of these technologies remains to be discussed. This research determines the variables and social actors that characterize the Fintech ecosystem. For this purpose, a descriptive design was employed under the methodology of structural analysis, making use of tools such as a panel of experts and the MICMAC software (Matrix of Crossed Impacts Multiplication Applied to a Classification). The results suggest that investment, customer management and behavior due to COVID-19 are considered key variables in the current Fintech market. While the SBS (Superintendency of Banking, Insurance and AFP), Peruvian Fintech companies and clients are considered as the preponderant social actors. The findings constitute a basis for the design and strategic planning of future scenarios aimed at minimizing risks and making the most of the opportunities offered by this industry 4.0 new market.
The STEM Wage Premium in the Main Brazilian Technology Clusters
Authors:   the State University of Santa Catarina, Av Madre Benvenuta, 2037, Florianópolis, SC, 88035-001 Brazil, Bonini P. , Custodio C. F.
Published: November 2023

This paper reports research results on Science Technology Engineering and Mathematics – STEM – wage premium in 10 main Brazilian technologic clusters: Manaus, Ilhéus-Itabuna, Belo Horizonte, Pouso Alegre, Curitiba, Porto Alegre, Florianópolis, Campinas, São Carlos and São Paulo. The study adjusts the Oaxaca decomposition method – which allows using the workers’ occupation as a categorical variable – to estimate the median of the STEM wage premium in each of the clusters. The control variables are age, educational level, and experience, which are proxy variables for human capital. Inspection of data reveals that the STEM workforce is more educated and has more stability in the job. The statistical analysis suggests that the median of the STEM wage premium obtained by workers in the ten clusters is higher than observed in development countries. This may indicate that Brazilian STEM labor force should will is still grow to meet demand.
The Concept of “USSR” in the Space of Regional Historical Memory (on the Example of the Komi Republic)
Authors: Koshelev Dmitry
Published: November 2023

The Soviet period in Russian history causes extremely ambiguous judgments, assessments and discussions in the modern scientific community. They concern, for the most part, the general aspects of the existence of Soviet society and the state, the role of the USSR in world history, the achievements of the Soviet economy, science, culture, wars, the problems of the Gulag system, etc. The historical and cultural environment today is becoming a key concept of modern society and is not a separate area of state regulation, but a complex multi-level system. Historical components are the basis for the development of society in the modern world. In the field of preserving the memory of the past, stability and continuity can be achieved through the potential of historical memory and successful coordination of activities.
Al-Idrisi at the Court of the Christian Sovereign
Authors: Konovalova Irina
Published: November 2023

The paper examines the history of cooperation between two outstanding personalities of the 12th century — the Arab geographer al-Idrisi and the king of Norman Sicily Roger II, by whose order and with whose assistance al-Idrisi created the geographical work “The Book of Pleasant Journeys into Faraway Lands”, which included, in addition to describing the ecumene, detailed maps. An analysis of the history of the creation of this work from the point of view of such a discipline as the geography of knowledge leads to an understanding of the features of both the form and the content of al-Idrisi’s work. Despite the fact that al-Idrisi borrowed the general principle of land description according to latitudinal zones-climates from the Islamic geographical tradition, his approach to the depiction of the countries and peoples of the world reveals significant differences from the practice of Islamic scientists. In his work, al-Idrisi creates a space devoid of hierarchy, homogeneous in terms of value, permeated with paths that connected cities and countries.
The Personality of Augustine in the Context of Source Studies (Main Research Directions of the 19th — 21st Centuries)
Authors: Petrov Filipp
Published: November 2023

The paper notes that the study of the personality of Augustine (354—430) and his writings is inextricably linked with his ideas on the soul, which occupy an important place in European religious and philosophical thought. Indeed, referring to any of the teachings of Augustine — whether it is the doctrine of the universe, time, memory, the relationship between free will and divine predestination, and others, — one should take into account his ideas on soul. The so-called psychologism of Augustine, noted by researchers of his vast creative heritage, is also associated with them. Those texts of Augustine which seem to be the most significant for the reconstruction and study of Augustine’s psychological concept are identified. There are “Confessions”, “On Order”, “On the Immortality of the Soul”, “The Soliloquies”, “City of God”, and others. It is noted that Augustine does not devote one or another of his works only to the problem of the soul; that his views on the soul can be reconstructed from individual fragments and lines taken from many other of his texts, diverse in terms of content, genre and problematic; that the involvement of the entire corpus of Augustine’s writings will allow not only to clarify his thought, to show the course of his reasoning, but also to study his psychological teaching more carefully.
Niccolo Machiavelli as a Symbolic Personality: from Political Theory to Political Pedagogy
Authors: Gutorov Vladimir
Published: November 2023

The paper analyzes in detail the concept of “Machiavellianism” — a constantly emerging and growing giant intellectual segment that combines historical, psychological and philosophical interpretations with frankly vulgar ideological speculations. Modern concepts of personality are being explored, the synthesis of which is well represented in the works of Hans Jürgen Eysenck. W. Colman’s theory of symbols is also analyzed because of its great contribution to understanding the reasons why Machiavelli’s personality gradually began to turn into a kind of symbol that characterizes the process of forming a very specific “cultural code” of human thinking and behavior. The authors also examine the reasons why modern discussions around the personality and cultural heritage of Machiavelli are increasingly moving into a very specific theoretical area called “political pedagogy”.
Determining quality of hire, the holy grail of recruitment: A structuration perspective
Authors: Dutta Debolina , Vedak Chaitali
Published: November 2023

Purpose: This research paper aims to justify the need for the Quality of Hire (QOH) construct as a value-adding focus for strategic human resource management (SHRM). The traditional focus on efficiency and cost-oriented recruitment metrics overlooks the importance of QOH in providing a competitive advantage and delivering long-term value. The study expands the economic theory of human resource development and develops a profit-building concept relevant to SHRM by exploring the practices that enable QOH in organizations. Design: The study utilizes a case-study method to examine a target firm’s mechanisms to build QOH in its recruitment process. It applies a structuration theory lens to analyze the behavior of various actors, their agencies, and the continuous interplay between structure and action in enabling QOH. Findings: The findings suggest that assessing and building measures for getting QOH is a complex task for organizations due to the inherent reliance on lag measures such as performance and tenure. The study highlights that QOH can be enabled through changes in the firm’s recruitment practices. Originality: This paper contributes to recruitment research in two significant ways. First, it expands on the under-researched construct of QOH, providing clarity on its definition and importance. Second, it identifies lead practices that organizations can incorporate into their recruitment and selection processes to enable QOH. By using a structuration theory lens, the study explores how actors in the recruitment process adapt and align with new structural rules to enable QOH. Research implications: The research builds on the structuration theory in recruitment and selection and exhorts practitioners in organizations to move beyond efficiency-oriented recruitment practices and focus on practices that contribute to QOH. By considering post-hire outcomes, such as job performance and long-term retention, organizations can improve their talent acquisition and retention strategies, creating long-term value for the organizations.
BUILDING POWER AND TRUST
Authors: Yassine Fatima-Ezzahra , El Kortbi Imane , Nekhass Houssame , Housni Hamid
Published: November 2023

This paper falls within a conjunction of translation studies, crisis communication, and social media communication. It sheds light on the critical role of translation in crisis management, with a focus on how the aforementioned elements of scrutiny converge and collaborate in the milieu of the outraging global pandemic. Likewise, the paper seeks to reveal the way translating information and information exchange enhances public trust.  Therefore, it emphasizes how discourse can heavily contribute to building trust during a global health emergency and how translation can offer power to the source language/culture by relocating its emanating knowledge to the rest of the world. Likewise, the paper seeks to discuss the way translating information and information exchange enhances public trust. The present paper is a qualitative study that recovers data from selected translated discourses imparted by organizations as well as a questionnaire inquiring about the communicative content disseminated through social media networks during the COVID-19 pandemic. The article scrutinizes the data in terms of content, based on communication content analysis to shed light on how translation could be a powerful tool of relocating meaning production in establishing trust and the extent to which social media is effective as a crisis management mechanism. The further aim of this study is to demonstrate how internet communities and networking technologies can influence deep-rooted forms of communication adopted by governments and the way social media dynamics enhance or undermine the information-translation process at times of crisis. The preliminary data, contrary to what has been assumed, shows that non-expert reactions, attitudes, feelings, experiences, and trends are transmitted via social media and algorithmically analyzed, influencing the information cycle in real time. The networked-translation paradigm focuses less on a one-to-many communication style that uses language, context, and reasoning to persuade receivers and more on a many-to-many communication style that uses audiovisual means to mobilize crowds. (Van Dijck & Alinejad, 2020)
REPENSER LA COMMUNICATION SOCIO-PÉDAGOGIQUE DANS L'ÈRE POST-COVID
Authors: Ben Khajjou Ibrahim
Published: November 2023

En raison du contexte imposé par la pandémie de COVID-19, les établissements scolaires ont dû revoir leurs méthodes d'enseignement. Cette étude se penche sur une approche novatrice pour l'enseignement du français auprès des élèves du secondaire en utilisant les ressources d'Internet. L'objectif principal de cette recherche était d'évaluer l'efficacité d'une méthode particulière d'enseignement du français. Pour ce faire, des expérimentations ont été menées au moyen d'une plateforme en ligne, permettant aux utilisateurs d'interagir en français. Ces interactions impliquaient des locuteurs natifs de la langue française et des apprenants du français en tant que langue étrangère. Au cœur de cette démarche, les participants étaient libres de choisir les sujets de leurs conversations. L'étude s'est penchée sur les thèmes abordés ainsi que sur les perceptions des participants concernant ces interactions. Les résultats de cette étude ont révélé des différences significatives entre les approches et les comportements des deux groupes, à savoir les locuteurs natifs et les apprenants du français. Les locuteurs natifs ont démontré une propension à interagir de manière spontanée et détendue, échangeant leurs idées sans être excessivement préoccupés par la précision linguistique. Dans leurs interactions, l'accent était davantage mis sur l'établissement de relations sociales et sur l'exploration des aspects interculturels et sociaux de la communication. L'utilisation fréquente d'emojis et d'abréviations soulignait le caractère informel de ces échanges, avec une moindre préoccupation pour les normes linguistiques formelles. En contraste, les apprenants du français adoptaient une approche plus formelle dans leurs interactions. Ils percevaient souvent l'exercice comme une évaluation académique et interagissaient en conséquence, s'adressant préférentiellement à l'enseignant plutôt qu'aux autres participants. Cette dynamique reflétait une vision de l'apprentissage des langues comme une compétence académique centrée sur la communication avec un enseignant plutôt qu'une compétence pratique pour interagir dans la société. Ces constats soulignent l'importance de prendre en compte les perceptions et les attitudes des apprenants lors de la conception des approches pédagogiques. Ils mettent en évidence un écart potentiel entre les intentions sous-jacentes à l'approche socio-interactionnelle et son interprétation par les usagers. En conséquence, il apparaît essentiel de repenser la présentation des activités en ligne et de favoriser une vision élargie de l'apprentissage des langues. Cette vision doit soutenir à la fois l'acquisition de compétences communicatives pratiques et l'interaction authentique avec des locuteurs natifs. En conclusion, l'approche socio-interactionnelle offre un cadre pédagogique novateur qui transcende les approches traditionnelles, en mettant l'accent sur le développement de compétences pratiques et communicatives essentielles pour une utilisation effective de la langue dans divers contextes.
ROLE DE L’APPROCHE HUMAINE DANS LA GESTION COMMUNICATIONNELLE D’UNE CRISE
Authors: Boulahrouf Hanane , El Kortbi Imane , Mouaaid Nouha , Maati Alaoui Fennane Moulay , Lahiala Abdelfattah
Published: November 2023

Dans l'exercice de son activité, aucune organisation n'est immunisée contre les situations de crise. Crises majeures de santé publique, ruptures organisationnelles, effondrements de système ou éclatements culturels sont des situations qui tendent à échapper au monde de l'exceptionnel (LAGADEC, 1991). La crise sanitaire Covid-19 est une crise d'envergure planétaire. Elle a bouleversé le fonctionnement de tous les systèmes en l'occurrence les systèmes éducatifs. Au Maroc, les pouvoirs publics ont entrepris des stratégies et des mesures afin de limiter au plus grand degré les effets de la crise sur la scolarité des étudiants et d'assurer une continuité pédagogique. En vue de concrétiser ces mesures, une activité importante de communication a été déployée. Cette gestion communicationnelle ambitionnait à informer les étudiants sur les changements prévus et à leurs impliquer dans le nouveau mode d'apprentissage, qui a été assuré à distance. Durant cette période difficile, les étudiants devaient suivre les cours  assurés par leurs enseignants et s'adapter avec cette transition. L'étudiant, confronté à une telle situation, a besoin d'aide psychique et affective d'où la nécessité d'une approche humaine de la communication de crise. Notre communication vise donc à montrer l'importance d'une approche humaine dans l'efficacité de la gestion communicationnelle d'une crise, cas: scolarisation des étudiants marocains lors de la crise sanitaire de Covid-19.
Rise of Bitcoin, Economic Inequality and the Ecology
Authors: Benshushan Gal
Published: November 2023

What do we know about the interrelations between economic inequality, ecology and the increased use of Bitcoin? The aim of the paper was to empirically test the relationship between economic and ecological effects related to the increase in Bitcoin’s network hashrate in a selection of countries that have the highest influx of crypto-mining. To test these three types of relationships, I collected a dataset concerning Bitcoin indicators, economic indicators and ecological indicators that were obtained from multiple trustworthy sources: OECD, World Bank, Fred Data, World Inequality Database (WID). Handling the data challenges, I used this unique panel dataset to explore the relationship between Bitcoin’s hashrate and two types of outcomes: (i) economic outcomes (such as the GDP which as we know relates to inequalities through the Kuznets curve) or direct measures of inequality (such as, income inequality (GINI) and the share of people with top 1% of income and 1% of wealth), and (ii) ecological outcomes (such as carbon emissions, carbon footprint and electronic waste). I found that the Bitcoin currency associates with certain redistribution of wealth, but the accumulation of crypto-currency-related wealth itself remains still concentrated in the wealth of the top 1%. Also, there is evidence for certain nonlinearities in the relationships with the ecological degradation, echoing the concept of the Kuznets curve.
Influence of the introduction technique of metal nickel additives into the metal-hydride electrode's active mass on the hermetically-sealed nickel-metal-hydride battery performance
Authors:   Saratov State University, Stepanov A. N. , Savina E. E. ,   JSC NIIHIT Experimental Plant, Kocharmin A. S. ,   Saratov State University, Kurbanova E. I. ,   Saratov State University, Kazarinov I. A. ,   Saratov State University, Taldykina T. I. ,   JSC NIIHIT Experimental Plant, Golikova N. Y. ,   JSC NIIHIT Experimental Plant
Published: November 2023

The influence of the way of introduction of metallic nickel as a binder into the active mass of the metal hydride electrode (MH) on the discharge characteristics of the NMH-6-type hermetically-sealed nickel-MH batteries was examined. Preliminary microcapsulating of the hydrogen-sorbing alloy by means of reduction chemical deposition of metallic nickel is shown to result in a significant increase of the discharge characteristics of the nickel-MH battery (by 45% in a whole), to enable introduction of carbonylic nickel into the active mass of the MH electrode to be completely excluded, and to raise the gas cycle efficiency in the hermetically-sealed nickel-MH battery.
Ineficacia de ciertas estipulaciones en acuerdos sobre derechos patrimoniales de autor y derechos conexos y sus efectos materiales
Authors: González López Felipe
Published: November 2023

Los últimos cambios introducidos en la legislación autoral colombiana en materia de acuerdos sobre derechos de autor y derechos conexos, generaron una serie de interrogantes de orden práctico en el sector, relacionados con los efectos materiales de su aplicación a las relaciones contractuales suscritas con anterioridad a la vigencia de la ley que introdujo las modificaciones correspondientes, al igual que frente a aquellos acuerdos que se celebren con posterioridad a la vigencia de la misma. Lo anterior, particularmente, en lo concerniente a la consagración de estipulaciones contractuales que prevean formas de explotación o modalidades de utilización de derechos patrimoniales de autor o conexos, que sean inexistentes o desconocidas al tiempo de convenir la transferencia, autorización o licencia, toda vez que, las mismas, tienen como sanción la ineficacia de la respectiva disposición, llevando a interpretaciones equivocas, según las cuales, la aparición de nuevas tecnologías, medios y/o escenarios de explotación inexistentes al momento de la suscripción del contrato, se verían afectados por la sanción descrita.
La dimensión jurídica en el discurso científico. Infracciones de los derechos de propiedad intelectual
Authors: Pavó Acosta Rolando , Bicet Dorzón Osmany
Published: November 2023

Este trabajo pretende demostrar la existencia de una dimensión jurídica en el discurso científico, resaltando la importancia de que sea observada, una de cuyas variables fundamentales es el respeto a los derechos de propiedad intelectual. Para alcanzar la anterior meta, se realizó una investigación cualitativa, en la cual la revisión bibliográfica recayó en artículos y libros que trataran sobre las infracciones a los derechos de propiedad intelectual y a los derechos personales en el ámbito de las obras científicas, localizados en la base de datos Google Académico, priorizándose los publicados a partir del 2017. Se empleó también el método del análisis jurídico comparativo y el método del análisis exegético jurídico de las normas en materia de derecho de autor. Se aporta una definición acerca de la dimensión jurídica, las variables para su evaluación, los límites al discurso en las obras científicas y la argumentación sobre la necesidad del reconocimiento de tal dimensión, a partir de la vigencia de los derechos humanos. Se aporta además un estudio, desde perspectiva doctrinal y de análisis jurídico comparativo, del plagio en las obras científicas, los tipos de plagio y las posibles soluciones.
Experience of Adults with Substance Use, Mental Health, and Homelessness Issues: A Combined 12-Step Faith-Based Program and Complementary Therapeutic Recreation Interventions
Authors: Litchke Lyn G. , Irvine Vanessa P. , Ervin Amanda R.
Published: November 2023

There is a significant association between substance use disorder (SUD) and mental health (MH) issues for adults experiencing homelessness. Therapeutic Recreation (TR) is utilized as a treatment intervention for many populations including individuals experiencing SUD and MH issues through the use of recreation and leisure to address various physical, cognitive, emotional, social, and spiritual needs, as well as improve quality of life and well-being. Thus, the purpose of this study was to examine the experience of 12 adults with SUD, MH, and homelessness issues engaging in a variety of evidence-based practice (EBP) TR led activities involving complementary integrative health (CIH), adventure teambuilding, and creative arts combined with a 12-step faith-based recovery meeting. Twelve sessions took place for 2 hours, twice a week over 6 weeks at a residential treatment Christian mission. The thematic analysis revealed three overarching themes: 1) building a caring community, 2) finding a new enjoyable way out of addiction, and 3) calm healing through creative complementary spiritual activities. These findings indicate that combining various forms of EBP TR activities with peer support 12-step faith-based meeting added value to the recovery process. This case study adds to the current literature on how the combining EBP TR with a 12-step faith-based approach might aide in the healing process for adults with MH, SUD, and homelessness problems.
Impact of an After-School Club on Elementary Students’ and Staff Members’ Physical Activity Levels, Mood Levels, and Stress Levels
Authors: McGovern Katherine , Hodges Kulinna Pamela
Published: November 2023

Guided by the conceptual framework of the Comprehensive School Physical Activity Program (CSPAP), the purpose of this study was to determine if a walking club after school for teachers and students increased physical activity levels, reduced stress, and improved mood. The participants were 51 (67% male, 33% female) fourth- to eighth-grade students and eight staff members at a charter school in the Southwest United States, along with nine comparison teachers. They participated in an 8-week after-school walking/running club twice a week for 45 min. Participants wore a pedometer and completed validated instruments to assess stress levels and mood. Descriptive statistics were performed. Group differences were explored with t tests. Overall, the average number of steps during the 13 school days for students was 7,657 (SD = 2,661). The after-school program added an additional 2,585 (SD = 699) steps to their day. Staff members were less active at school with 5,896.33 (SD = 2,617) steps, but equally or more active in the after-school program with 3,063 (SD = 331) steps. The t-test results were significant, showing students and teachers reported less stress at the end of the program. Only staff members completed the mood instrument, and there were significantly more positive mood indicators and fewer negative mood indicators at the posttest. Comparison teachers had similar steps at school. Because the intervention group of teachers reported more stress at pretest, their decreased stress values were similar to the comparison teachers at posttest. Participating in an after-school walking/running club can increase daily physical activity, decrease stress levels, and improve overall mood, specifically, if teachers want to feel more interested and inspired and less distressed, irritable, and nervous.
Optimization of Rooting Behaviour by the Application of IBA on the Cuttings of Queens Flower (Lagerstroemia speciosa)
Authors: Fariz V. , Shedage Swati , Mannengal Mohammed Shamsan , Dipika Ayate
Published: November 2023

Background: Queen’s flower (Lagerstroemia speciosa) is an important ornamental plant that is utilised in residential landscape and avenue plantation for both public and private purposes around the world. Seed dormancy problem in Lagerstroemia which negatively affects germination. To overcome the challenges associated with seed propagation, researchers have explored rooted Lagerstroemia speciosa cuttings as an alternative method. Methods: Three concentrations of IBA (Indole-3- butyric acid) @ 1000 ppm, 2000 ppm and 3000 ppm were used to root initiation of Lagerstroemia speciosa stem cuttings. There were four treatments: 1000 ppm, 2000 ppm, 3000 ppm and control. Result: The 2000 ppm IBA treatment performed the better response in comparision to other treatments and recorded, 79 per cent rooting, followed by the treatment 3000 ppm IBA, (76 per cent rooting) and in the control, (68 per cent). In 2000 ppm IBA, the percentage of rooting, the number of roots per cutting and the length of the longest roots all are at their peak as well as showed the superior growth performance. The growth parameters of IBA-@ 2000 ppm treated cuttings revealed that this is the optimum IBA concentration for Lagerstroemia speciosa propagation trough cuttings in a semi-arid climate.
A experiência da Natureza e o potencial pedagógico nos 1º e 2ºs ciclos do Ensino Básico
Authors: Couto Sabina , Loureiro Domingos
Published: November 2023

O artigo apresenta, de forma resumida, um projeto de investigação focado na experiência da Natureza e o potencial pedagógico no Ensino Básico, especificamente do primeiro e do segundo ciclos. É aqui refletido sobre o contato reduzido das crianças com os espaços naturais exteriores e a sua exploração, situação que tem vindo a aumentar acentuadamente em Portugal, sendo mencionados alguns dos fatores que encaminham para a perda sucessiva desse contato. Procura-se perceber, a partir de estudos internacionais e nacionais, o tempo despendido em atividades pedagógicas ao ar livre, em que o recreio surge como principal elemento de relação com o exterior; dados sobre as atividades pedagógicas realizadas no exterior; e o tipo de contatos com a Natureza. Esta investigação reúne, ainda, o estudo de três projetos pedagógicos, nomeadamente: “Dia de aulas ao ar livre”, “Limites invisíveis: educação na natureza” e “Escola da Floresta Bloom” que abordam, em Portugal, a aproximação das crianças com o espaço natural como essencial para o desenvolvimento cognitivo, motor e social. Pretende-se compreender quais as razões que estão na base da criação destes projetos, quais os seus objetivos, programas e resultados, avaliando potenciais utilizações ou melhorias, no âmbito laboratorial da investigação a ser desenvolvida no Doutoramento em Educação Artística.
Silêncio que invade e liberta
Authors: Loureiro Domingos
Published: November 2023

O texto apresenta uma perspetiva pessoal sobre a importância do Silêncio para a compreensão do processo de trabalho e da obra de Francisco Laranjo. O silêncio apresenta-se como uma condição empírica, mas, igualmente, como conceito associado ao transcendente e ao sagrado, sendo chave para a reflexão e contemplação da obra do artista, recentemente desaparecido. Neste contexto, o silêncio assume-se como figura do desconhecido onde operam diversos estados de associação, interpretação e performance, na sua prática artística. Desta forma, propõe-se que as suas obras sejam compreendidas como território em si, que não se referem a algo concreto, mas que operem como espelho para pensar o mundo. Assim, propõe-se que as obras sejam entendidas como um lugar, como paisagem, sugerindo-se a designação de paisagem-pintura para caracterizar as obras de pintura realizadas por Francisco Laranjo.
Francisco Laranjo
Authors: Strambi Marta Luiza , Martins Farina Mauricius
Published: November 2023

Neste texto nos propomos pensar sobre algumas imagens monocromáticas de Francisco Laranjo a partir dos conceitos de intuição e sentimento da forma. Uma única concessão possível para o ser da poética é uma tal verdade que se guarda na expressão de sua própria necessidade. Na arte, as relações de compartilhamento com ou outro, implicam em estar em presença daquilo que conecta culturas e polaridades distintas. As energias da arte se abrem por dentro, e é assim que se alimenta uma investigação, pela alteridade, pela renovação.
Breast Cancer Early Detection Training Through Correct Sadari and Sadanis to Midwifes and Nurses
Authors: Arianto Bambang , Hendarsih Een , Arumasari Pravica Juti
Published: November 2023

Breast cancer ranks first in terms of the number of cancers in Indonesia and is among the first contributors to cancer deaths. This is because 70% of the cases are detected at an advanced stage. After finding a lump in her breast, a patient does not necessarily see a doctor immediately. The cause of the problem is the lack of public knowledge about breast cancer. Therefore, prompt efforts are needed to solve this problem. Training for health workers, including midwives and nurses, in direct contact with the community regarding early detection and breast cancer therapy is essential. The hope is that midwives and nurses will become breast cancer health cadres through counseling, early detection, and treatment in the community. The results of this activity are increased knowledge among midwives and nurses about breast cancer, its early detection, and early treatment, which correlates with decreased delays in treatment
The Relationship of Physical Activity and Sleep Quality Toward Hypertension Prevalence in Sumberngepoh Village, Malang, Indonesia
Authors: Jayanata M. Gita , Fauziah Adhima  , Khansa Talitha Rafif  , Ludy Diana Wiradhika  , Muhamad Bagus Wira  , Ramidha Syaharani  , Sarah Nia  , Samsriyaningsih Handayani
Published: November 2023

Hypertension is the highest among non-communicable diseases in Indonesia and the world, with prevalence showing an increase yearly. One of the determinants is having health-risk behaviors such as low levels of physical activity and sleep quality. These risk factors also have a relationship with hypertension in rural areas. This study aims to find the relationship between physical activity, poor sleep quality, and the prevalence of hypertension in Sumberngepoh, Lawang, Malang, Indonesia. This was a case-control study involving a population of Sumberngepoh Village residents older than 18 years old. The assessment of physical activity was measured using the Indonesian Ministry of Health's PTM cohort study questionnaire. The sleep quality was measured using the IFLS-5 questionnaire. Data analysis was performed using SPSS version 27 with univariate analysis using the Chi-square test with a significance value of <0.05. If the expected value was <5, Fisher's exact test was used. logistic regression test was employed for the multivariate analysis. The level of physical activity was significantly related to hypertension (p<0.05). However, the sleep quality was not significantly related to hypertension (p>0.05). Multivariate analysis showed that the level of physical activity was significantly related to hypertension, with an odds ratio of moderate to strenuous physical activity of 0.134. The prevalence of hypertension was significantly related to the level of physical activity in the age group more than 18 years old in Sumberngepoh, Lawang, Malang, Indonesia.
Team Approach: Organizing and Empowering Multidisciplinary Teams in Postfragility Fracture Care
Authors: Becerril Daniela Varona , Dirschl Douglas R.
Published: November 2023

» Numerous healthcare roles can be valuable and effective participants in postfracture care programs (PFCPs) and can also serve effectively as program liaisons/champions.

» Greatest success seems to have been achieved when a single entity provides cohesive and consistent training, coordination, shared goals, and accountability for program sites and site leaders.

» Few PFCPs have solved what seems to be the fundamental challenge of such programs: how to maintain program effectiveness and cohesion when the patient makes the inevitable transition from acute care to primary care? Creating a partnership with shared goals with primary care providers is a challenge for every program in every location.

» Programs located in the United States, with its predominantly “open” healthcare system, seem to lag other parts of the world in overcoming this fundamental challenge.

» It is hoped that all PFCPs in all systems can learn from the successes of other programs in managing this critical transition from acute to primary care.
Unlocking the Healing Potential
Authors: Shahzad Hania , Lee Maximillian , Munjal Vikas , Veliky Cole , Yu Elizabeth
Published: November 2023

» Cannabinoids, such as D9-tetrahydrocannabinol and cannabidiol, interact with endocannabinoid receptors in the central nervous system and immune system, potentially offering pain relief. The entourage effect, resulting from the interaction of multiple cannabis components, may enhance therapeutic impact and efficacy, making them promising candidates for exploring pain relief in spine operations, known to be among the most painful operative procedures.

» The use of cannabinoids in pain management requires careful consideration of safety, including their cognitive and psychomotor effects, potential cardiovascular risks, risk of dependence, mental health implications, and drug interactions.

» Few studies have analyzed cannabinoid use in relation to spine surgery, with variable results reported, indicating possible effects on reoperation rates, mortality, complications, postoperative opioid use, and length of hospital stay.

» Current knowledge gaps exist in the understanding of cannabinoid effects on spine surgery, including the exploration of different administration routes, timing, dosage, and specific outcomes. In addition, mechanistic explanations for the observed results are lacking.

» Ethical considerations related to informed consent, medical expertise, societal impact, and legal compliance must also be thoroughly addressed when considering the utilization of cannabinoids in spinal pathologies and back pain treatment.
Toxoplasmosis and Chlamydophilosis in Small Ruminant Farms in Cameroon: Knowledge, Attitudes, Practices and Perception of Zoonotic Risks of Farmers
Authors: Nankam Roland Chimi , Kouamo Justin , Kouam Michel Alain Simo , FOTSAC Muller DZOUSSE , DEMBENG Raphael CHERMAPI , KOUENGOUA Armelle Prudence KOUENGOUA , Ngoula Ferdinand
Published: November 2023

Zoonotic abortive diseases represent a significant health and economic risk for national public health. This cross-sectional survey was conducted from April to October 2021 among 200 selected small ruminant farmers in the three northern regions of Cameroon. Data collection was done through questionnaires administered by exchange with the herder and responses were coded and recorded on an Excel spreadsheet. The data were then analyzed with R software, version 2.13.0. An ANOVA test was used to assess significant differences in mean of Knowledge, Attitudes, Practices and Perception of zoonotic risks (KAPP) scores between regions. Pearson correlations were used to calculate the association between KAPP scores within regions. Small ruminant farmers surveyed had low mean scores for knowledge of abortive Toxoplasmosis and Chlamydophilosis(0.1 ± 0.2), desirable attitude (0.32 ± 0.07), appropriate practice (0.36 ± 0.13) in managing abortion, and positive perception of zoonotic risks of Toxoplasmosis and Chlamydophilosisin small ruminants (0.12 ± 0.33), respectively. KAPP was significantly (p<0.01) and positively associated with knowledge (r=0.98) and risk perception (r=0.99). However, attitudes (r=0.06), practices (r=0.05) and risk perception of toxoplasmosis (r=0.07) and Chlamydophilosis (r=0.08) were not associated with farmers' knowledge. This study revealed significant knowledge gaps, low levels of desired attitudes, and high-risk behavioral practices. These results therefore call for capacity building of health professionals and farmers to better integrate the One Health concept in the management of neglected zoonotic diseases.
Risk factors of postoperative C5 Palsy after open-door laminoplasty with titanium plates
Authors: Doi Kazuma , Tani Satoshi , Mizuno Junichi
Published: November 2023

Study Design: A retrospective study
Objectives:C5 palsy is one of the well-known side effects of cervical posterior decompression or fusion surgery, and it might be caused by multifactorial etiology. Examining risk factors for postoperative C5 palsy is the goal of this investigation.
Setting:General Hospital in Kanagawa, Japan
Methods:An analysis was performed on 132 adult patients who underwent open-door cervical laminoplasty for degenerative diseases in our single center between January 2015 and October 2021. Eight patients (6.1%) developed C5 palsy, although seven of the eight cases made a full recovery without additional surgery. We compared the demographic and radiographic traits of the C5 palsy group with those of the non-C5 palsy group.
Results:In the C5 palsy group, the preoperative T2-high lesion on magnetic resonance imaging (MRI) was present in 62.5% whereas it was positive in
20.3% in the non-C5 palsy group (p=0.021). Besides, the C4/5 foraminal minimal distance on the open side was 2.42 ± 0.84 mm in the C5 palsy group whereas it was 3.58 ± 0.94 mm in the non-C5 palsy group (p = 0.001).
Conclusion:The preoperative T2-high lesion on MRI and C4/5 foraminal stenosis on the open side are risk factors for postoperative C5 palsy following open-door laminoplasty with titanium plates.
Mirvetuximab Soravtansine in Solid Tumors: A Systematic Review and Meta-Analysis
Authors: Rehim Shamsnur , Yuan Shuang , Wang Hongjing
Published: November 2023

Background: Mirvetuximab Soravtansine (MIRV) is a promising antibody‒drug conjugate (ADC) that targets folate receptor alpha (FRα), which is overexpressed in several types of solid tumors. In November 2022, MIRV was approved in the USA for the treatment of adult patients with FRα-positive, platinum-resistant epithelial ovarian, fallopian tube or primary peritoneal cancer who received 1-3 prior systemic treatment regimens. Therefore, high-quality evidence for its efficacy and safety in different cancers is urgently needed.
Methods: A systematic search (e.g., PubMed, Embase, Web Of Science, Cochrane Library) was conducted to identify all relevant clinical trials of MIRV alone or in combination with chemo- and/or target-therapies in solid tumors. The primary end-point was median progression-free survival (mPFS). The secondary endpoints were the overall response rate (ORR) and adverse effects (AEs). A random-effects model was applied.
Results: The study included nine research studies with a total of 682 patients. The pooled mPFS and pooled ORR were 6.70 months (95% CI 4.54–8.86,I2=96.21%) and 36% (95% CI: 28% to 44%, I2=76.79%), respectively. Significant differences were observed among intervention regimens and response to platinum. The pooled mPFS of MIRV monotherapy and MIRV+ BEV combined therapy was 4.28 (95% CI 3.90–4.65, I2=0.00%) and 7.78 (95% CI 6.62-8.95, I2=0.00%), respectively. The pooled ORRs of MIRV monotherapy and MIRV+BEV combined therapy were 25% (95% CI 21%–29%, I2=25.20%) and 43% (95% CI 36%–50%, I2=0.01%), respectively. The pooled ORRs of the platinum-sensitive, platinum-resistant groups were 59% (95% CI 36%–81%, I2=61.88%), 33% (95% CI 25%–40%, I2=69.73%), respectively. In addition, we conducted supplementary subgroup analyses to explore the influence of FRα receptor expression levels and the number of prior treatments on treatment outcomes. The most common adverse effects were blurred vision (45.20%), nausea (40.13%), diarrhea (39.52%), fatigue (33.84%) and keratopathy (31.20%).
Conclusions: MIRV has significant therapeutic effects in solid tumors, especially when combined with BEV. In platinum-tolerant tumors, the efficacy of MIRV is also considerable. Overall, MIRV is relatively safe in solid tumors, and adverse reactions are relatively rare and mild.
Systematic analysis of NDUFAF6 in complex I assembly and mitochondrial disease
Authors: Pagliarini David , Sung Andrew , Guerra Rachel , Steenberge Laura , Alston Charlotte , Murayama Kei , Okazaki Yasushi , Shimura Masaru , Prokisch Holger , Ghezzi Daniele , Torraco Alessandra , Carrozzo Rosalba , ROTIG Agnes , Taylor Robert , Keck James
Published: November 2023

Isolated complex I (CI) deficiencies are a major cause of primary mitochondrial disease. Two-thirds of CI deficiencies arise from defects in CI assembly factors (CIAFs) that are not part of the CI holoenzyme. The biochemistry of CIAFs is poorly defined, making their role in CI assembly unclear and confounding interpretation of potential disease-causing genetic variants. To address these challenges, we devised a deep mutational scanning approach to systematically assess the function of thousands of NDUFAF6 genetic variants. Guided by these data, biochemical analyses, and cross-linking mass spectrometry, we discovered that the CIAF NDUFAF6 facilitates incorporation of NDUFS8 into CI and reveal that NDUFS8 overexpression rectifies NDUFAF6 deficiency. Our data further provide experimental support of pathogenicity for seven novel NDUFAF6 variants associated with human pathology and add phenotypic annotation for 5,675 additional variants. Overall, our work defines the function of NDUFAF6 and provides a comprehensive clinical resource for diagnosing NDUFAF6-related diseases.
Evaluation of the Efficacy & Safety of Amustaline/Glutathione Pathogen Reduced RBCs in Complex Cardiac Surgery: the Red Cell Pathogen Inactivation (ReCePI) Study - Protocol for a Phase 3, Randomized, Controlled Trial
Authors: Snyder Edward L. , Sekela Michael E. , Welsby Ian J. , Toyoda Yoshiya , Alsammak Mohamed , Sodha Neel R. , Beaver Thomas M. , Pelletier J. Peter R. , Kaplan Alesia , Sniecinski Roman M. , Reece T. Brett , Pearl Ronald G. , Davenport Robertson D. , Gorham James D. , McNeil John S. , Sarode Ravi , Ipe Tina S. , Nuttall Gregory A. , Lopez-Plaza Ileana , Benharash Peyman , Gammon Richard R. , Sadler Patrick , Pitman John P. , Liu Kathy , Bentow Stanley , Corash Laurence , Mufti Nina , Varrone Jeanne , Benjamin Richard J.
Published: November 2023

Background

Red blood cell (RBC) transfusion is a critical supportive therapy in cardiovascular surgery (CVS). Donor selection and testing have reduced the risk of transfusion-transmitted infections; however, risks remain from bacteria, emerging viruses, pathogens for which testing is not performed and from residual donor leukocytes. Amustaline (S-303)/glutathione (GSH) treatment pathogen reduction technology is designed to inactivate a broad spectrum of infectious agents and leucocytes in RBC concentrates. The ReCePI study is a Phase 3 clinical trial designed to evaluate the efficacy and safety of pathogen reduced RBCs transfused for acute anemia in CVS compared to conventional RBCs, and to assess the clinical significance of treatment-emergent RBC antibodies.

Methods

ReCePI is a prospective, multicenter, randomized, double-blinded, active-controlled, paralleldesign, non-inferiority study. Eligible subjects will be randomized up to 7 days before surgery to receive either leukoreduced Test (pathogen reduced) or Control (conventional) RBCs from surgery up to Day 7 post-surgery. The primary efficacy endpoint is the proportion of patients transfused with at least one study transfusion with an acute kidney injury (AKI) diagnosis defined as any increased serum creatinine (sCr) level ≥0.3 mg/dL (or 26.5 µmol/L) from presurgery baseline within 48±4 hours of the end of surgery. The primary safety endpoints are the proportion of patients with any treatment-emergent adverse events (TEAEs) related to study RBC transfusion through 28 days, and the proportion of patients with treatment-emergent antibodies with confirmed specificity to pathogen reduced RBCs through 75 days after the last study transfusion. With ≥292 evaluable, transfused patients (>146 per arm), the study has 80% power to demonstrate non-inferiority, defined as a Test group AKI incidence increase of no more than 50% of the Control group rate, assuming a Control incidence of 30%.

Discussion

RBCs are transfused to prevent tissue hypoxia caused by surgery-induced bleeding and anemia. AKI is a sensitive indicator of renal hypoxia and a novel endpoint for assessing RBC efficacy. The ReCePI study is intended to demonstrate the non-inferiority of pathogen reduced RBCs to conventional RBCs in the support of renal tissue oxygenation due to acute anemia and to characterize the incidence of treatment-related antibodies to RBC.