bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Non-canonical Spatial Symmetry on Subitizing
Authors: Hsin Chih-Yen , Lo Yu-Hui , Tseng Philip
Published: July 2021

Subitizing refers to ability of people to accurately and effortlessly enumerate a small number of items, with a capacity around four elements. Previous research showed that “canonical” organizations, such as familiar layouts on a dice, can readily improve subitizing performance of people. However, almost all canonical shapes found in the world are also highly symmetrical; therefore, it is unclear whether previously reported facilitative effect of canonical organization is really due to canonicality, or simply driven by spatial symmetry. Here, we investigated the possible effect of symmetry on subitizing by using symmetrical, yet non-canonical, shape structures. These symmetrical layouts were compared with highly controlled random patterns (Experiment 1), as well as fully random and canonical patterns (Experiment 2). Our results showed that symmetry facilitates subitizing performance, but only at set size of 6, suggesting that the effect is insufficient to improve performance of people in the lower or upper range. This was also true, although weaker, in reaction time (RT), error distance measures, and Weber Fractions. On the other hand, canonical layouts produced faster and more accurate subitizing performances across multiple set sizes. We conclude that, although previous findings mixed symmetry in their canonical shapes, their findings on shape canonicality cannot be explained by symmetry alone. We also propose that our symmetrical and canonical results are best explained by the “groupitizing” and pattern recognition accounts, respectively.
Identifying Mixture Components From Large-Scale Keystroke Log Data
Authors: Li Tingxuan
Published: July 2021

In a computer-based writing assessment, massive keystroke log data can provide real-time information on students’ writing behaviors during text production. This research aims to quantify the writing process from a cognitive standpoint. The hope is that the quantification may contribute to establish a writing profile for each student to represent a student’s learning status. Such profiles may contain richer information to influence the ongoing and future writing instruction. Educational Testing Service (ETS) administered the assessment and collected a large sample of student essays. The sample used in this study contains nearly 1,000 essays collected across 24 schools in 18 U.S. states. Using a mixture of lognormal models, the main findings show that the estimated parameters on pause data are meaningful and interpretable with low-to-high cognitive processes. These findings are also consistent across two writing genres. Moreover, the mixture model captures aspects of the writing process not examined otherwise: (1) for some students, the model comparison criterion favored the three-component model, whereas for other students, the criterion favored the four-component model; and (2) students with low human scores have a wide range of values on the mixing proportion parameter, whereas students with higher scores do not possess this pattern.
Attributed Contribution of Therapist’s Emotional Variables to Psychotherapeutic Effectiveness: A Preliminary Study
Authors: Romero-Moreno Antonio , Paramio Alberto , Cruces-Montes Serafín , Zayas Antonio , Guil Rocío
Published: July 2021

Background

The aim of this manuscript is to analyze the degrees of responsibility for healing that psychotherapists attribute to a set of emotional variables of the therapist involved in the therapeutic process. Such variables, framed within the well-known common factors in psychotherapy, have been proven to be essential in making the therapeutic process effective, as has been shown by research in psychotherapy in recent decades.

Materials and Methods

Based on an extensive literature review, the responses from a sample of 69 psychotherapists to a tool createdad hocare analyzed to verify whether their attributions are in line with the results of said review.

Results

The therapists have doubts about the factors responsible for psychotherapeutic effectiveness, as well as about the value of common variables, including those of an emotional nature, not valuing them above those of a specific type. They also argue against the similar effectiveness of different psychotherapeutic models.

Conclusion

Discrepancies have thus been found between the conclusions reached by research on therapeutic processes and the statements made by the therapists studied, which could indicate an insufficient impact of psychotherapeutic research on clinical practice. We also propose courses of action such as establishing training programs for the acquisition and development of emotional skills for therapists that could increase the effectiveness of their interventions.
Assessing the Effect of a Visual Navigational System on Route-Learning From an Ecological Perspective
Authors: Heft Harry , Schwimmer Kelsey , Edmunds Trenton
Published: July 2021

Route-learning, considered from an ecological approach to perception, is posited to involve the detection of information over time that specifies a path from one location to another. The study examines whether the use of a visual navigational system (e.g., GPS) may impede route-learning by drawing attention away from transitions along a path that serve as information for way-finding. Virtual reality (VR) technology used in conjunction with an extensive, detailed environmental simulation was employed to explore this possibility. One group of participants drove a simulated car in VR along a designated path while relying on visual GPS guidance. It was expected that use of the GPS display would draw attention away from temporally continuous path information. A second group initially drove the same route without GPS guidance. Both groups drove the path a second time without navigational assistance. Overall, the percentage of correct actions taken at intersections (transitions) during the second trial were significantly lower for the first group who initially drove the route with visual GPS guidance as compared to those who initially traveled the route without it. The results are consistent with the kind of trade-off that is commonplace when tools are used to mediate and assist skilled action.
Automated Analysis of Digitized Letter Fluency Data
Authors: Cho Sunghye , Nevler Naomi , Parjane Natalia , Cieri Christopher , Liberman Mark , Grossman Murray , Cousins Katheryn A. Q.
Published: July 2021

The letter-guided naming fluency task is a measure of an individual’s executive function and working memory. This study employed a novel, automated, quantifiable, and reproducible method to investigate how language characteristics of words produced during a fluency task are related to fluency performance, inter-word response time (RT), and over task duration using digitized F-letter-guided fluency recordings produced by 76 young healthy participants. Our automated algorithm counted the number of correct responses from the transcripts of the F-letter fluency data, and individual words were rated for concreteness, ambiguity, frequency, familiarity, and age of acquisition (AoA). Using a forced aligner, the transcripts were automatically aligned with the corresponding audio recordings. We measured inter-word RT, word duration, and word start time from the forced alignments. Articulation rate was also computed. Phonetic and semantic distances between two consecutive F-letter words were measured. We found that total F-letter score was significantly correlated with the mean values of word frequency, familiarity, AoA, word duration, phonetic similarity, and articulation rate; total score was also correlated with an individual’s standard deviation of AoA, familiarity, and phonetic similarity. RT was negatively correlated with frequency and ambiguity of F-letter words and was positively correlated with AoA, number of phonemes, and phonetic and semantic distances. Lastly, the frequency, ambiguity, AoA, number of phonemes, and semantic distance of words produced significantly changed over time during the task. The method employed in this paper demonstrates the successful implementation of our automated language processing pipelines in a standardized neuropsychological task. This novel approach captures subtle and rich language characteristics during test performance that enhance informativeness and cannot be extracted manually without massive effort. This work will serve as the reference for letter-guided category fluency production similarly acquired in neurodegenerative patients.
Qualitative Study on the Toxic Triangle Integration of Leadership Ostracism
Authors: Chen Zhixia , Sun Mei
Published: July 2021

Leadership ostracism widely exists in all types of organizations, yet specific study regarding this trend is limited. With this study, we explore the influencing mechanisms of leadership ostracism through case interview based on literature analysis and grounded theory. Results show that leadership ostracism is the integration of a triadic interaction process between subordinate performance, leadership characteristics, and organizational environment. Based on Padilla's destructive leadership toxic triangle model, we constructed a toxic triangle model of leadership ostracism. Through comparison, we found that these two triad models overlap in the areas of narcissism and power consciousness of supervisors, the self-concept of subordinates, and the management system of situational factors, indicating that leadership ostracism is itself a type of destructive leadership. In addition, the uniqueness, and differences in leadership ostracism are reflected in the model, including stereotypes, and results orientation of supervisors, political skills, job performance, and cognitive style of subordinates, the power distance, Chaxu climate, and organizational politics of the situational elements. Theoretical and practical implications are discussed in the research field that provides prospects for future orientation.
Using Generalizability Theory and Many-Facet Rasch Model to Evaluate In-Basket Tests for Managerial Positions
Authors: Li Guangming , Pan Yuxi , Wang Weijun
Published: July 2021

Purpose: This study aimed to analyze interview data collected from a series of in-basket tests during managerial personnel recruitment in a local Chinese company, taking advantage of the use of combination of Generalizability theory (GT) and Many-facet Rasch Model (MFRM), rather than the Classical Test Theory (CTT).

Design/Methodology/Approach: Participants included 78 candidates (Mage = 37.76, SD = 6.36; 35.9% female) interviewed for eight managerial positions in a local Chinese company. Data were collected based on a series of 10 in-basket interview tests, and a 20-item rating scale (the in-basket test rating scale; IBTRS) was developed and piloted, and five expert raters rated the participants on their performance in five aspects (planning, communication and coordination, capital operations and management, analysis and problem solving, and empowerment and controlling). The data were analyzed using a crossed design of p × i × r, where p represents person, i represents item, and r represents rater. Effects of candidate (person), test item, rater, and the interaction of item and rater were examined.

Findings: The use of the combination of GT and MFRM was able to provide accurate, comprehensive information over the process of in-basket interview tests. Specifically, GT analysis showed good generalization coefficient and reliability index (0.893 and 0.871, respectively), and the variation of candidates explained most of the total variance (53.22%). The candidates scored high in the dimension of empowerment and controlling. There were differences in the severity of raters. Three raters should be sufficient to ensure good scoring stability.

Originality/Value: This study used the combination of GT and MFRM to assess the interview data instead of using a CTT approach.
A Randomised Controlled Trial of Clinician-Guided Internet-Based Cognitive Behavioural Therapy for Depressed Patients in Singapore
Authors: Lu Sharon H. X. , Assudani Hanita A. , Kwek Tammie R. R. , Ng Shaun W. H. , Teoh Trisha E. L. , Tan Geoffrey C. Y.
Published: July 2021

This study examined the efficacy and acceptability of a hybrid, clinician-guided internet-based Cognitive Behavioural Therapy (iCBT) programme for outpatients with depression in a psychiatric hospital in Singapore. Fifty three participants were randomly assigned to a treatment or wait-list control group before they underwent a cross-over of conditions. Treatment consisted of a 4-week iCBT with three face-to-face sessions. 60.9% of participants who received treatment completed all six modules. Intention-to-treat analysis showed treatment was associated with significant reductions in symptoms of depression, anxiety and psychological distress but not in functional impairment, while the control condition was not associated with changes in any measures. These reductions had moderate to large effect sizes (ESs) for symptoms of depression and anxiety, and moderate ES for psychological distress. The between-group difference in depression score had a moderate ES. There was a significant between-group treatment effect in depressive symptoms, but not in the other measures. Treatment gains were maintained at 3-month follow-up. Most of the participants were highly satisfied with the programme, with 90 percent stating they would recommend it. This is the first RCT to provide preliminary evidence for the efficacy and acceptability of iCBT for depression in Singapore.
Heteronormativity and the Justification of Gender Hierarchy: Investigating the Archival Data From 16 European Countries
Authors: Ferrari Federico , Imperato Chiara , Mancini Tiziana
Published: July 2021

Within the framework of the System Justification Theory, this study tested on the archival data from 16 European countries the general hypothesis that homonegativity (HN), as an expression of gender binarism and heteronormativity, works as a legitimizing myth of gender hierarchy. Specifically, we hypothesized that (1) system justification (SJ) would positively relate to HN and (2) this relation would depend on the country level of gender hierarchy, (3) on the gender of respondents, and (4) on the interaction between gender hierarchy and gender. We selected the Gender Equality Index (GEI) as an indicator of the gender hierarchy of the country system and the items from the European Social Survey-Round 9 (ESS-9) as the indicators of the gender of respondents and the levels of SJ and HN. The Hierarchical Linear Modeling (HLM) partially confirmed the hypotheses, suggesting HN to work as a blatant prejudice and being more viable as a legitimizing myth in females from countries with higher gender hierarchy and in males from more gender-equal countries. In both cases, HN serves as a myth to justify the ontological premise of participants that the world is fair and to counteract the cognitive dissonance generated by the perception of a gender-unequal system (in the case of a woman) or by the perception of a gender-equal system that can threaten gender privileges (in the case of a man).
Patterns of Lifetime Criminality in Mentally Disordered Offenders – Findings From a Nationally Representative Cohort
Authors: Krona Hedvig , Anckarsäter Henrik , Nilsson Thomas , Hofvander Björn
Published: July 2021

Background: Treatment of mentally disordered offenders (MDOs) is challenging as their behavior and clinical conditions can be traced to a complex constellation of major mental disorders, substance use and antisocial lifestyle. Finding subgroups of these offenders, which could guide treatment and risk assessment, is desirable. There are few long-term, prospective studies of risk factors for persistent criminal behavior among MDOs.

Aims: The aims are (1) to provide a map of lifetime criminality in MDOs, (2) to identify subgroups of offenders, and (3), if such clusters exist, to test whether they differ in lifetime criminality and patterns of negative events during in-patient treatment.

Methods: Background data on all offenders from the Malmö University Hospital catchment area sentenced to forensic psychiatric in-patient treatment 1999–2005 (n = 125) was collected. Data on negative events during treatment (violence, threats, absconding and substance use) from date of admittance until discharge or until June 30, 2008 was gathered. Court decisions for 118 of the cohort-individuals were collected from the 1st of January 1973 until December 31, 2013. We used hierarchical cluster analysis to identify subgroups and MANOVA-analysis to examine differences between these clusters on lifetime criminality variables and negative events. A MANCOVA was used to control for time in treatment.

Results: The cohort was sentenced to a total of 3,380 crimes (944 violent) during the study period. Median age at first crime was 20 years (range 15–72), and at first violent crime 27 years (range 15–72). A subgroup (n = 26) was characterized by childhood adversities, neurodevelopmental disorders and later substance use disorders and was more often associated with substance-related crimes, financial crimes and lower age at first crime. During treatment, this cluster showed higher rates of substance use and threats. When controlling for treatment time, no differences in negative events were found.

Conclusions: This study replicated findings from prison populations of the existence of a more criminally persistent phenotype characterized by early-onset neurodevelopmental and behavior disorders, childhood adversities and later substance use disorders. We did not find this cluster of variables to be related to negative events during inpatient treatment when controlling for length of stay.
Systematic Review of Integration and Radicalization Prevention Programs for Migrants in the US, Canada, and Europe
Authors: Del Pino-Brunet Natalia , Hombrados-Mendieta Isabel , Gómez-Jacinto Luis , García-Cid Alba , Millán-Franco Mario
Published: July 2021

Background: International migration processes are some of the most important events of our time. Migrating implies a broad range of factors that affect integration, and which may be linked to radicalization. Host countries use different methods for the integration of migrants. The aim of this systematic review is to analyze intervention programs that aim at promoting social integration and preventing the radicalization of migrants, with the objective of studying actions carried out in the US, Canada, and Europe to this effect.

Method: Worldwide known bibliographic databases (PsyCINFO, Sociological Abstracts, Psycarticles, Psychology Database, Medline, SCOPUS, and Google Scholar) were used to search studies published before January 2019 and which analyzed integration or radicalization prevention programs with migrants.

Results: A total of 601 studies were screened, from which 18 met the inclusion criteria. The analysis of programs addressed to migrant women points to a decrease in loneliness and depression and an increase of migrants' perception of social support and self-esteem. Programs carried out in schools and families improve children's knowledge of their culture and that of others, increase their feelings of inclusion, and reduce their aggressiveness, stress, and anxiety. Language programs promote communication and employment search, as well as improve migrants' quality of life. One of the most effective activities included in these programs is to connect recently arrived migrants with local population and/or long-term residents. The latter act as mentors and teachers, helping recently arrived migrants understand resources and to be more integrated in the new country, as well as reducing discrimination from the local population.

Conclusions: The review concluded the importance of intervention programs for integration, migrants' quality of life, prevention of extreme behaviors, and intercultural cohabitation. Future programs must be more detailed regarding participants' information and carry out more comprehensive assessments.
Psychosocial Moderators and Mediators of Sensorimotor Exercise in Low Back Pain: A Randomized Multicenter Controlled Trial
Authors: Wippert Pia-Maria , Niederer Daniel , Drießlein David , Beck Heidrun , Banzer Winfried , Schneider Christian , Schiltenwolf Marcus , Mayer Frank
Published: July 2021

The effects of exercise interventions on unspecific chronic low back pain (CLBP) have been investigated in many studies, but the results are inconclusive regarding exercise types, efficiency, and sustainability. This may be because the influence of psychosocial factors on exercise induced adaptation regarding CLBP is neglected. Therefore, this study assessed psychosocial characteristics, which moderate and mediate the effects of sensorimotor exercise on LBP. A single-blind 3-arm multicenter randomized controlled trial was conducted for 12-weeks. Three exercise groups, sensorimotor exercise (SMT), sensorimotor and behavioral training (SMT-BT), and regular routines (CG) were randomly assigned to 662 volunteers. Primary outcomes (pain intensity and disability) and psychosocial characteristics were assessed at baseline (M1) and follow-up (3/6/12/24 weeks, M2-M5). Multiple regression models were used to analyze whether psychosocial characteristics are moderators of the relationship between exercise and pain, meaning that psychosocial factors and exercise interact. Causal mediation analysis were conducted to analyze, whether psychosocial characteristics mediate the exercise effect on pain. A total of 453 participants with intermittent pain (mean age = 39.5 ± 12.2 years, f = 62%) completed the training. It was shown, that depressive symptomatology (at M4, M5), vital exhaustion (at M4), and perceived social support (at M5) are significant moderators of the relationship between exercise and the reduction of pain intensity. Further depressive mood (at M4), social-satisfaction (at M4), and anxiety (at M5 SMT) significantly moderate the exercise effect on pain disability. The amount of moderation was of clinical relevance. In contrast, there were no psychosocial variables which mediated exercise effects on pain. In conclusion it was shown, that psychosocial variables can be moderators in the relationship between sensorimotor exercise induced adaptation on CLBP which may explain conflicting results in the past regarding the merit of exercise interventions in CLBP. Results suggest further an early identification of psychosocial risk factors by diagnostic tools, which may essential support the planning of personalized exercise therapy.

Level of Evidence: Level I.

Clinical Trial Registration: DRKS00004977, LOE: I, MiSpEx: grant-number: 080102A/11-14. https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00004977.
Between Action and Emotional Survival During the COVID-19 era: Sensorimotor Pathways as Control Systems of Transdiagnostic Anxiety-Related Intolerance to Uncertainty
Authors: Goldstein Ferber Sari , Shoval Gal , Zalsman Gil , Mikulincer Mario , Weller Aron
Published: July 2021

Objectives: The COVID-19 pandemic and aligned social and physical distancing regulations increase the sense of uncertainty, intensifying the risk for psychopathology globally. Anxiety disorders are associated with intolerance to uncertainty. In this review we describe brain circuits and sensorimotor pathways involved in human reactions to uncertainty. We present the healthy mode of coping with uncertainty and discuss deviations from this mode.

Methods: Literature search of PubMed and Google Scholar.

Results: As manifestation of anxiety disorders includes peripheral reactions and negative cognitions, we suggest an integrative model of threat cognitions modulated by sensorimotor regions: “The Sensorimotor-Cognitive-Integration-Circuit.” The model emphasizes autonomic nervous system coupling with the cortex, addressing peripheral anxious reactions to uncertainty, pathways connecting cortical regions and cost-reward evaluation circuits to sensorimotor regions, filtered by the amygdala and basal ganglia. Of special interest are the ascending and descending tracts for sensory-motor crosstalk in healthy and pathological conditions. We include arguments regarding uncertainty in anxiety reactions to the pandemic and derive from our model treatment suggestions which are supported by scientific evidence. Our model is based on systematic control theories and emphasizes the role of goal conflict regulation in health and pathology. We also address anxiety reactions as a spectrum ranging from healthy to pathological coping with uncertainty, and present this spectrum as a transdiagnostic entity in accordance with recent claims and models.

Conclusions: The human need for controllability and predictability suggests that anxiety disorders reactive to the pandemic's uncertainties reflect pathological disorganization of top-down bottom-up signaling and neural noise resulting from non-pathological human needs for coherence in life.
OCD Influences Evidence Accumulation During Decision Making in Males but Not Females During Perceptual and Value-Driven Choice
Authors: Ma Xiao , Megli Ashton , Pittenger Christopher , Pushkarskaya Helen
Published: July 2021

Individuals with obsessive-compulsive disorder (OCD) often have difficulty making decisions. Valuation and value-based judgements are particularly difficult. The mechanisms underlying these impairments are still poorly understood. Previous work has suggested that individuals with OCD require more information prior to making a choice during perceptual discrimination tasks. Little previous work has examined value-guided choice in OCD. Here we examined perceptual and value-based decision making in adults with OCD, using a novel task in which the two types of decision are tested in parallel using the same individually calibrated sets of visual stimuli (Perceptual and Value-based decision-making task, PVDM). Twenty-seven unmedicated participants with OCD (16 female) and thirty-one healthy controls (15 female) were tested. Data were analyzed using hierarchical drift-diffusion modeling (HDDM). Decision formation was altered in OCD, but differentially between genders: males with OCD, but not females, accumulated more information (i.e., were more cautious) and were less effective in evidence accumulation than age- and IQ-matched healthy males. Furthermore, males with OCD, but not females, were less likely than controls to adjust the process of evidence accumulation across decision contexts. These unexpectedly gender-dimorphic effects suggest that more attention should be paid to gender differences in studies of OCD, and of pathophysiology more broadly.
Predicting Complex Traits and Exposures From Polygenic Scores and Blood and Buccal DNA Methylation Profiles
Authors: Odintsova Veronika V. , Rebattu Valerie , Hagenbeek Fiona A. , Pool René , Beck Jeffrey J. , Ehli Erik A. , van Beijsterveldt Catharina E. M. , Ligthart Lannie , Willemsen Gonneke , de Geus Eco J. C. , Hottenga Jouke-Jan , Boomsma Dorret I. , van Dongen Jenny
Published: July 2021

We examined the performance of methylation scores (MS) and polygenic scores (PGS) for birth weight, BMI, prenatal maternal smoking exposure, and smoking status to assess the extent to which MS could predict these traits and exposures over and above the PGS in a multi-omics prediction model. MS may be seen as the epigenetic equivalent of PGS, but because of their dynamic nature and sensitivity of non-genetic exposures may add to complex trait prediction independently of PGS. MS and PGS were calculated based on genotype data and DNA-methylation data in blood samples from adults (Illumina 450 K; N = 2,431; mean age 35.6) and in buccal samples from children (Illumina EPIC; N = 1,128; mean age 9.6) from the Netherlands Twin Register. Weights to construct the scores were obtained from results of large epigenome-wide association studies (EWASs) based on whole blood or cord blood methylation data and genome-wide association studies (GWASs). In adults, MSs in blood predicted independently from PGSs, and outperformed PGSs for BMI, prenatal maternal smoking, and smoking status, but not for birth weight. The largest amount of variance explained by the multi-omics prediction model was for current vs. never smoking (54.6%) of which 54.4% was captured by the MS. The two predictors captured 16% of former vs. never smoking initiation variance (MS:15.5%, PGS: 0.5%), 17.7% of prenatal maternal smoking variance (MS:16.9%, PGS: 0.8%), 11.9% of BMI variance (MS: 6.4%, PGS 5.5%), and 1.9% of birth weight variance (MS: 0.4%, PGS: 1.5%). In children, MSs in buccal samples did not show independent predictive value. The largest amount of variance explained by the two predictors was for prenatal maternal smoking (2.6%), where the MSs contributed 1.5%. These results demonstrate that blood DNA MS in adults explain substantial variance in current smoking, large variance in former smoking, prenatal smoking, and BMI, but not in birth weight. Buccal cell DNA methylation scores have lower predictive value, which could be due to different tissues in the EWAS discovery studies and target sample, as well as to different ages. This study illustrates the value of combining polygenic scores with information from methylation data for complex traits and exposure prediction.
Twenty-Four-Hour Heart Rate Is a Trait but Not State Marker for Depression in a Pilot Randomized Controlled Trial With a Single Infusion of Ketamine
Authors: Schiweck Carmen , Lutin Erika , De Raedt Walter , Cools Olivia , Coppens Violette , Morrens Manuel , Van Hoof Chris , Vrieze Elske , Claes Stephan
Published: July 2021

Background: Abnormalities of heart rate (HR) and its variability are characteristic of major depressive disorder (MDD). However, circadian rhythm is rarely taken into account when statistically exploring state or trait markers for depression.

Methods: A 4-day electrocardiogram was recorded for 16 treatment-resistant patients with MDD and 16 age- and sex-matched controls before, and for the patient group only, after a single treatment with the rapid-acting antidepressant ketamine or placebo (clinical trial registration available on https://www.clinicaltrialsregister.eu/ with EUDRACT number 2016-001715-21). Circadian rhythm differences of HR and the root mean square of successive differences (RMSSD) were compared between groups and were explored for classification purposes. Baseline HR/RMSSD were tested as predictors for treatment response, and physiological measures were assessed as state markers.

Results: Patients showed higher HR and lower RMSSD alongside marked reductions in HR amplitude and RMSSD variation throughout the day. Excellent classification accuracy was achieved using HR during the night, particularly between 2 and 3 a.m. (90.6%). A positive association between baseline HR and treatment response (r = 0.55, p = 0.046) pointed toward better treatment outcome in patients with higher HR. Heart rate also decreased significantly following treatment but was not associated with improved mood after a single infusion of ketamine.

Limitations: Our study had a limited sample size, and patients were treated with concomitant antidepressant medication.

Conclusion: Patients with depression show a markedly reduced amplitude for HR and dysregulated RMSSD fluctuation. Higher HR and lower RMSSD in depression remain intact throughout a 24-h day, with the highest classification accuracy during the night. Baseline HR levels show potential for treatment response prediction but did not show potential as state markers in this study.

Clinical trial registration: EUDRACT number 2016-001715-21.
Increases in Cognitive Activity Reduce Aging-Related Declines in Executive Functioning
Authors: Stieger Mirjam , Lachman Margie E.
Published: July 2021

Declines in cognitive functioning are commonly experienced with aging, yet there is wide variation in the nature and extent of these changes. Previous research has shown associations between the frequency of engaging in stimulating cognitive activities and performance on cognitive tests. However, it is not known whether it is important to increase the amount of cognitive activity as one gets older in order to curtail cognitive declines. We examined cognitive activities and cognition in a national sample of 2,130 community-dwelling middle-aged and older adults from the Midlife in the United States longitudinal study. Participants completed cognitive assessments of episodic memory (EM) and executive functioning (EF) on two occasions, ~9 years apart. At the first assessment, participants ranged in age between 33 and 83 years (M = 55.76, SD = 11.09), with 56.1% women. Multilevel models were tested to examine educational level and change in cognitive activity as predictors of change in EM and EF, controlling for initial level of cognitive activity and key correlates of cognitive decline. Results indicated that increases in cognitive activity were important over and above earlier levels of cognitive activity for reducing declines in EF. Further analysis also showed differential results by educational level. Increased cognitive activity was not associated with changes in EF among individuals with a college degree. In contrast, individuals without a college degree who increased their cognitive activity showed significantly less decline in EF compared to those without a college degree who decreased or maintained their cognitive activity across the 9 years. Thus, the results suggest that increased engagement in cognitive activity makes more of a difference for EF declines among those without a college degree. The results have particular relevance given that aging-related changes in domains such as work status, health, or social relationships can lead to reductions in stimulating cognitive activities. The findings emphasize the importance of increasing cognitive activities especially among those with lower educational attainment.
A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19
Authors: Logette Emmanuelle , Lorin Charlotte , Favreau Cyrille , Oshurko Eugenia , Coggan Jay S. , Casalegno Francesco , Sy Mohameth François , Monney Caitlin , Bertschy Marine , Delattre Emilie , Fonta Pierre-Alexandre , Krepl Jan , Schmidt Stanislav , Keller Daniel , Kerrien Samuel , Scantamburlo Enrico , Kaufmann Anna-Kristin , Markram Henry
Published: July 2021

Graphical Abstract
How Transportation Restriction Shapes the Relationship Between Ambient Nitrogen Dioxide and COVID-19 Transmissibility: An Exploratory Analysis
Authors: Han Lefei , Zhao Shi , Cao Peihua , Chong Marc K. C. , Wang Jingxuan , He Daihai , Deng Xiaobei , Ran Jinjun
Published: July 2021

Background: Several recent studies reported a positive (statistical) association between ambient nitrogen dioxide (NO2) and COVID-19 transmissibility. However, considering the intensive transportation restriction due to lockdown measures that would lead to declines in both ambient NO2 concentration and COVID-19 spread, the crude or insufficiently adjusted associations between NO2 and COVID-19 transmissibility might be confounded. This study aimed to investigate whether transportation restriction confounded, mediated, or modified the association between ambient NO2 and COVID-19 transmissibility.

Methods: The time-varying reproduction number (Rt) was calculated to quantify the instantaneous COVID-19 transmissibility in 31 Chinese cities from January 1, 2020, to February 29, 2020. For each city, we evaluated the relationships between ambient NO2, transportation restriction, and COVID-19 transmission under three scenarios, including simple linear regression, mediation analysis, and adjusting transportation restriction as a confounder. The statistical significance (p-value < 0.05) of the three scenarios in 31 cities was summarized.

Results: We repeated the crude correlational analysis, and also found the significantly positive association between NO2 and COVID-19 transmissibility. We found that little evidence supported NO2 as a mediator between transportation restriction and COVID-19 transmissibility. The association between NO2 and COVID-19 transmissibility appears less likely after adjusting the effects of transportation restriction.

Conclusions: Our findings suggest that the crude association between NO2 and COVID-19 transmissibility is likely confounded by the transportation restriction in the early COVID-19 outbreak. After adjusting the confounders, the association between NO2 and COVID-19 transmissibility appears unlikely. Further studies are warranted to validate the findings in other regions.
A Narrative Review of Function-Focused Measures for Children With Neurodevelopmental Disorders
Authors: Shanmugarajah Kajaani , Rosenbaum Peter , Zubairi Mohammad , Di Rezze Briano
Published: July 2021

Clinical measures in health and rehabilitation settings are often used to examine child functioning to better support the diverse needs of children with neurodevelopmental disorders (NDD) and their families. The WHO's International Classification of Functioning, Disability, and Health (ICF) framework reflects a focus of health beyond biomedical deficits, using the concept of functioning to create opportunities for measurement development involving this construct. In the measures developed in the field of childhood NDD, it is unclear whether and how these tools measure and incorporate the ICF framework and its domains within health care contexts. Understanding how these measures utilize the ICF will enable researchers and clinicians to operationalize function-focused concepts in studies and clinical practice more effectively. This narrative review aims to identify and describe function-focused measures that are based on the ICF for children with NDD, as described in the peer-reviewed literature. This review used a systematic search strategy with multiple health-focused databases (Medline, PsycInfo, EMBASE, EMCARE), and identified 14 clinical measures that provide direct support for children (aged 0-21) with NDD in pediatric health (and other) settings. Results described the measures that were primarily developed for three main diagnostic populations [cerebral palsy, autism spectrum disorder, and communication disorders]; had varying contextual use (clinical-only or multiple settings); and for which authors had conducted psychometric tests in the measure's initial development studies, with the most common being content validity, interrater reliability, test-retest reliability. Participation (79%, n = 11) & Activities (71%, n = 10) were the most common ICF domains captured by the set of measurement tools. Overall (71%, n = 10) of the identified measures utilized multiple ICF domains, indicating that the “dynamic nature” of the interactions of the ICF domains was generally evident, and that this result differentiated from “linking rules,” commonly used in research and clinical practice. The implications of these findings suggest that clinical measures can be an effective application of the ICF's defined concepts of functioning for children with NDD.
The Robot is Present: Creative Approaches for Artistic Expression With Robots
Authors: Gomez Cubero Carlos , Pekarik Maros , Rizzo Valeria , Jochum Elizabeth
Published: July 2021

There is growing interest in developing creative applications for robots, specifically robots that provide entertainment, companionship, or motivation. Identifying the hallmarks of human creativity and discerning how these processes might be replicated or assisted by robots remain open questions. Transdisciplinary collaborations between artists and engineers can offer insights into how robots might foster creativity for human artists and open up new pathways for designing interactive systems. This paper presents an exploratory research project centered on drawing with robots. Using an arts-led, practice-based methodology, we developed custom hardware and software tools to support collaborative drawing with an industrial robot. A team of artists and engineers collaborated over a 6-month period to investigate the creative potential of collaborative drawing with a robot. The exploratory project focused on identifying creative and collaborative processes in the visual arts, and later on developing tools and features that would allow robots to participate meaningfully in these processes. The outcomes include a custom interface for controlling and programming robot motion (EMCAR) and custom tools for replicating experimental techniques used in visual art. We report on the artistic and technical outcomes and identify key features of process-led (as opposed to outcome-led) approaches for designing collaborative and creative systems. We also consider the value of embodied and tangible interaction for artists working collaboratively with computational systems. Transdisciplinary research can help researchers uncover new approaches for designing interfaces for interacting with machines.
On the Efficiency of Haptic Based Object Identification: Determining Where to Grasp to Get the Most Distinguishing Information
Authors: Xia Yu , Mohammadi Alireza , Tan Ying , Chen Bernard , Choong Peter , Oetomo Denny
Published: July 2021

Haptic perception is one of the key modalities in obtaining physical information of objects and in object identification. Most existing literature focused on improving the accuracy of identification algorithms with less attention paid to the efficiency. This work aims to investigate the efficiency of haptic object identification to reduce the number of grasps required to correctly identify an object out of a given object set. Thus, in a case where multiple grasps are required to characterise an object, the proposed algorithm seeks to determine where the next grasp should be on the object to obtain the most amount of distinguishing information. As such, the paper proposes the construction of the object description that preserves the association of the spatial information and the haptic information on the object. A clustering technique is employed both to construct the description of the object in a data set and for the identification process. An information gain (IG) based method is then employed to determine which pose would yield the most distinguishing information among the remaining possible candidates in the object set to improve the efficiency of the identification process. This proposed algorithm is validated experimentally. A Reflex TakkTile robotic hand with integrated joint displacement and tactile sensors is used to perform both the data collection for the dataset and the object identification procedure. The proposed IG approach was found to require a significantly lower number of grasps to identify the objects compared to a baseline approach where the decision was made by random choice of grasps.
Water Bears—The Most Extreme Animals on The Planet (And in Space!)
Authors: Elleuche Skander
Published: July 2021

Can you imagine that there is an eight-legged bear that tolerates colder temperatures than the polar bears do in the Arctic? Can you imagine that this bear is able to grow older than the grizzly bears in North America? And can you imagine that this bear grows by molting, like spiders or snakes? These so-called water bears, scientifically named tardigrades, are the most extreme animals on our planet. They not only survive in ice, but also in boiling water. Moreover, they can stop breathing for long periods and they have even traveled to outer space, surviving without an astronaut’s suit. Since water bears can withstand the harshest conditions on earth and beyond, they may teach us how we can protect ourselves from extreme environmental conditions.
MagneToRE: Mapping the 3-D Magnetic Structure of the Solar Wind Using a Large Constellation of Nanosatellites
Authors: Maruca Bennett A. , Agudelo Rueda Jeffersson A. , Bandyopadhyay Riddhi , Bianco Federica B. , Chasapis Alexandros , Chhiber Rohit , DeWeese Haley , Matthaeus William H. , Miles David M. , Qudsi Ramiz A. , Richardson Michael J. , Servidio Sergio , Shay Michael A. , Sundkvist David , Verscharen Daniel , Vines Sarah K. , Westlake Joseph H. , Wicks Robert T.
Published: July 2021

Unlike the vast majority of astrophysical plasmas, the solar wind is accessible to spacecraft, which for decades have carried in-situ instruments for directly measuring its particles and fields. Though such measurements provide precise and detailed information, a single spacecraft on its own cannot disentangle spatial and temporal fluctuations. Even a modest constellation of in-situ spacecraft, though capable of characterizing fluctuations at one or more scales, cannot fully determine the plasma’s 3-D structure. We describe here a concept for a new mission, the Magnetic Topology Reconstruction Explorer (MagneToRE), that would comprise a large constellation of in-situ spacecraft and would, for the first time, enable 3-D maps to be reconstructed of the solar wind’s dynamic magnetic structure. Each of these nanosatellites would be based on the CubeSat form-factor and carry a compact fluxgate magnetometer. A larger spacecraft would deploy these smaller ones and also serve as their telemetry link to the ground and as a host for ancillary scientific instruments. Such an ambitious mission would be feasible under typical funding constraints thanks to advances in the miniaturization of spacecraft and instruments and breakthroughs in data science and machine learning.
Understanding Factors Influencing Farmers' Engagement in Watershed Management Activities
Authors: Upadhaya Suraj , Arbuckle J. Gordon
Published: July 2021

Studies have pointed to a positive relationship between farmers' active engagement in watershed management (WM) and soil and water conservation practice adoption. If farmers' involvement in WM leads to more conservation, what predicts WM participation? This study seeks to answer that question through binomial logistic regression analysis of data from a survey of 6,006 Iowa farmers conducted to support the implementation of the Iowa Nutrient Reduction Strategy (NRS). Results indicate that public and private sector information sources, awareness of and attitudes regarding nutrient loss reduction strategies, farm contiguity to water bodies, and cost-share and technical assistance were positive predictors of farmers' engagement in WM, while lower agronomic self-efficacy, farm press as an information source, greater age, and higher farm sales were negative. Findings point to several potential actions to improve farmer involvement in WM: (1) more effectively engage with the farm press to disseminate information about the benefits of WM, (2) increase outreach to larger-scale farmers, and (3) focus on nutrient loss management capacity building. Further, a continued emphasis on awareness and attitudes related to the NRS and related actions, such as watershed management, may guide efforts to recruit farmers into watershed groups to help improve soil and water conservation outcomes.