bluuebunny/crossref_metadata_2025 huggingface dataset:
Unpacking Human Rights: Freedom of Consciousness, Bodily Autonomy & Right to Life in the Context of War on Drugs Crimes
Authors: Galanders Oskars
Published: November 2024

This study explores the interplay between the right to life, right to development, bodily autonomy and freedom of conscience, and demonstrates how these factors collectively shape the concept of freedom of consciousness and simultaneously lead to increased access to altered states of consciousness, cognitive liberty, freedom of development, and the peak experiences that Abraham Maslow researched.

Second chapter delves into the intersection of human rights and drug policy, specifically examining the implications of the War on Drugs on individual freedoms. It argues that the War on Drugs has led to a violation of fundamental human rights, including cognitive liberty, bodily autonomy, and the right to life. Through an analysis of international human rights law and case studies from around the world, the paper demonstrates how drug-related crimes have resulted in mass incarceration, violence, and human rights abuses. It also explores decriminalization of drug use, end of War on Drugs and criminalization of its’ crimes.

The research results provide insights into the interrelation between these three concepts, shedding light on how they intersect and influence each other and in context of War on Drugs hostile environment. Findings also suggest that the War on Drugs has resulted in a significant violation of fundamental human rights.
Judicial Immunity – A Guarantee of Independence and an Element of Accountability
Authors: Jurcena Laila
Published: November 2024

The aim of the article is to develop a common understanding of the content of judicial immunity and thus to generate a theory on the application of this legal institution in ensuring and balancing judicial independence and accountability. Neither the separation of powers nor the judicial independence precludes the assessment of a judge’s responsibility for violation of the law, however, it is in the interests of both the state and society to ensure the independent exercise of the judicial function. Therefore, there is a need to strike a balance between the independent exercise of the judicial function and the holding of judges accountable. This balance is ensured by judicial immunity. The research was carried out by using the methods of scientific research customary in legal science: literature studies, analytical, comparative, inductive and deductive research methods. The study reveals the aim of judicial immunity, describes its content focusing on two elements of the judicial immunity: non-liability and inviolability and reveals the specific requirements of judicial immunity. The study confirms that well-regulated and responsibly applied judicial immunity ensures that independence and accountability can be balanced.
The Challenges of the Presumption of Innocence in Lithuanian Criminal Proceedings
Authors: Nemeikšis Giedrius
Published: November 2024

Although one of the key principles of the criminal procedure law - the presumption of innocence is officially declared as an aspiration in Lithuanian legal regulation and case law, there are still some areas of possible threat to this key principle. Therefore, the purpose of this research paper is to identify and analyse specific problems of ensuring the presumption of innocence in Lithuanian criminal law and criminal procedure law. So, the analysis was based on three main questions: the difficulties of ensuring the presumption of innocence in the Lithuanian criminal procedural law and Lithuanian criminal law and in the context of media. The research was carried out by employing the logical, the systematic, the linguistic, the historical, the comparative and the synthesizing research methods as well as the analysis of legal documents. The results of research analysis revealed specific areas that pose the greatest threat to violation of the presumption of innocence, as grounds for the termination of a criminal case; the general basis for issuing a preventive measure (arrest); complicity where the accomplices are tried in separate cases and media statements that have a direct impact on the impartiality of judges.
Factors of the aging process and longevity—selected data
Authors: Sosiński Daniel , Tokarz-Deptuła Beata , Deptuła Wiesław
Published: November 2024

The article presents endogenous and exogenous factors affecting the aging process and longevity, indicating their influence on the epigenome and genome. While discussing endogenous factors, we described genes and protein complexes, metabolic and signaling pathways [IIS (insulin and insulin-like growth factor 1/IGF-1 signaling), ARE/Nrf2 (antioxidant response elements/nuclear factor erythroid-related factor 2), kynurenine/NAD+ (nicotinamide adenine dinucleotide and kynurenine signaling)], and the sirtuin enzyme group and antioxidant enzymes (e.g., SOD1).

While characterizing exogenous factors, we indicated the role of nutrition, including the effect of a diet balanced in terms of the number of calories and the effect of consuming polyphenols, including resveratrol, curcumin, or epigallocatechin-3-gallate, and vitamins C and E, as well as the impact of microclimate, stress, the role of physical exercise, and the use of pharmacological agents. Analysis of these data showed that the factors related to the aging process have an influence on longevity and age-related diseases.
ASEAN and European Union addressing the challenges of the 21st century
Authors: Chytopoulou Eleni
Published: November 2024

Subject and purpose of work

The European Union (EU) and the Association of Southeast Asian Nations (ASEAN) are trade partners and believe in rules-based multilateralism. They have developed strong ties despite starting from different starting points and having different standards. The EU is a mature regional cooperation scheme(union) with a highly institutionalized and legalized architecture. At the same time, ASEAN is an intergovernmental association with low institutionalization and legalization in which decisions are made by consensus. After almost fifty years of establishing a diplomatic dialogue between the EU and ASEAN, their cooperation has been of essential importance in maintaining peace and balancing great power rivalries.

Materials and methods

Bibliography in books and articles.

Results

The EU and ASEAN are among the world’s largest economies in terms of gross domestic product. The EU is already the world’s second-largest economy, and ASEAN could become the world’s fourth-largest economy by 2030. The EU looks forward to strengthening its economic cooperation with ASEAN to maintain its competitive position in the dynamically developing region of the Indo-Pacific. ASEAN is a crucial hub for transporting European goods and is essential in regional supply chains. Closer trade and investment relations could also help the EU achieve its goal of a strategic partnership between the two regional blocks encompassing political and economic cooperation. It would be desirable if the EU and ASEAN continue to connect Europe and Asia by acting as balancers and reducing tensions between the major international players.

Conclusions

In the 21st century, the rise of China, India, and other regional powers is consolidating a multipolar system and new geopolitical balances. In this new era, the EU and ASEAN can continue to connect Europe and Asia by acting as balancers and reducing tensions between the major international players.
Incidence and Clinical Predictors of Atrial Fibrillation in Patients with Dual-Chamber Pacemakers: A Retrospective Analysis
Authors: Ungureanu Adrian-Ionuţ , Negroiu Cristina Elena , Docea Anca Oana , Goanţă Emilia-Violeta , Târtea Georgică , Aniculăesei Anca-Adela , Mărginean Cristina Maria , Mitruţ Radu , Deutsch Marina-Carmen , Vătășescu Radu-Gabriel , Mitruţ Paul
Published: November 2024

Atrial fibrillation (AF) is a prevalent cardiac arrhythmia, affecting millions worldwide and increasing in frequency with age. Despite progress in treatment and prevention, AF remains a significant contributor to stroke, heart failure, and overall cardiovascular morbidity. One particularly challenging type of AF, paroxysmal atrial fibrillation (PAF), is often asymptomatic, leading to delayed diagnosis and increasing the risk of severe complications like stroke. The advent of cardiac implantable electronic devices (CIEDs) has significantly improved the ability to detect subclinical AF or atrial high-rate episodes (AHRE), even in patients with no symptoms. These devices, particularly pacemakers, offer long-term, continuous monitoring of atrial rhythms, making them an invaluable tool for diagnosing AF early and assessing its burden in real time.

This study focused on a cohort of patients from the Oltenia region who received dual-chamber pacemakers with no prior diagnosis of AF. The research aimed to monitor the incidence of AF in these patients over a follow-up period of 12 to 18 months and to identify potential clinical predictors for developing AF. A total of 91 patients were assessed in this study, all of whom received dual-chamber pacemakers by the pacing guidelines for conditions such as atrioventricular block and sick sinus syndrome. None of the patients had a history of AF at the time of implantation.

Follow-up results indicated an incidence of AHRE in 13.19% of patients, with significant predictors including advanced age and the presence of hypertension. These findings align with the broader literature, which consistently associates both factors with an increased risk of AF. The study underscores the importance of continuous monitoring in pacemaker patients, particularly for detecting asymptomatic AF, which may necessitate specific therapeutic interventions. Although the study’s sample size was limited, its findings contribute valuable insights into managing AF in pacemaker patients, particularly regarding early detection and potential risk factors. Future research with larger cohorts is necessary to confirm and expand these results.
Non-Pharmacological Management of Insomnia in Cancer Patients
Authors: Plăcintă Carmen Denisa , Brotea-Mosoiu Silvia Alina , Șerban Cătălina Elena , Galeș Laurenţia Nicoleta
Published: November 2024

Introduction. Insomnia is a common sleep disorder in cancer patients, characterized by a reduction in the quality or quantity of sleep. It can lead to fatigue, mood disturbances, and may contribute to immunosuppression, affecting both disease progression and quality of life.

Materials and methods. In an attempt to answer the question: “Does non-pharmacological treatment of insomnia improve the quality of life in cancer patients?”, we conducted a systematic search in the international databases PubMed and ScienceDirect, following the PRISMA guidelines. The search keywords were “insomnia,” “sleep disorders,” “cancer,” and “quality of life.”

Results. The systematic review included eight randomized trials that evaluated the effect of non-pharmacological therapies on insomnia and quality of life in oncology patients. Cognitive-behavioral therapy (CBT) is the first-line treatment with proven efficacy. Variants of CBT delivered through online platforms were found to be non-inferior in studies involving small patient groups. Another alternative treatment is acupuncture, which, while not as effective as CBT, improves sleep quality and enhances quality of life. Physical exercise, dance, nutrition programs, and psychological counseling also improve sleep and enhance quality of life compared to the usual hospital approaches.

Conclusions. Non-pharmacological treatment of insomnia improves the quality of life in cancer patients.
Chronic Kidney Disease and Oxidative Stress
Authors: Stoian Marilena , Gavrilă Bogdan , Ciofu Claudia , Turbatu Andrei
Published: November 2024

Disturbance of the balance between production of oxygen free radicals (or some other radical species) and activity of antioxidative system of protection causes the so called oxidative stress Protection of an organism from oxygen free radicals implies activity of enzymatic (catalase, SOD, glutathione peroxidase, glutathione reductase etc.) and nonenzymatic (vitamin E. vitamin C. glutathione, uric acid etc.) systems of protection. An organism can tolerate a mild oxidative stress but a higher disturbance between the production of free radicals and the activity of the antioxidative protection results in lipid protein and DNA as well as numerous diseases. In this article we analyze oxidative stress role as an important cofactor contributing to endothelial dysfunction, inflammation, atherosclerosis, glomerulosclerosis, anemia, tubulointerstitial nephritis and ischemia-reperfusion injury to chronic kidney disease patients.
Diagnostic and Therapeutic Meanders in a Wegener Disease - Case Report and Therapeutic Challenges
Authors: Cotea Andrei-Antonio , Mihălţan Florin-Dumitru , Mălăescu Andreea-Nicoleta , Constantin Ancuţa-Alina
Published: November 2024

Granulomatosis with polyangiitis (GPA), previously known as Wegener’s granulomatosis, is a vasculitis that primarily affects the respiratory tract and kidneys(1). Known as a rare disease, predominantly affects Caucasian adults aged between 45 and 60 years(2). While the specific cause remains unclear, it is believed that environmental factors play a role in triggering the condition in individuals who are genetically predisposed(3).

There is a wide range of clinical manifestations, comprising both general nonspecific symptoms(4) and organ-specific symptoms, with lung involvement in nearly 90% of patients(5). The diagnosis relies on clinical and imaging criteria, along with histopathological confirmation(2). Treatment consists of an induction phase, followed by a maintenance phase, utilizing glucocorticoids and immunosuppressants, which has greatly enhanced the prognosis for these patients(6).

The objective of this paper is to illustrate the complexity of GPA through the presentation of a clinical case. The patient is a 59-year-old man with a professional background involving exposure to respiratory toxins who presented to the clinic with intermittent mucopurulent cough, episodes of hemoptysis, nonspecific chest pain, bilateral knee pain, weight loss, and excessive nocturnal sweating. The imaging findings indicated significant polymorphic lesions in the lungs, and the diagnosis of GPA was confirmed via transthoracic biopsy.

Using a therapeutic strategy of immunosuppression and oral corticosteroid therapy, the patient’s clinical condition showed a modest improvement. The particularity of this case lies in the need to revise the treatment strategy for a patient identified as a non-responder to cyclophosphamide, given the imaging, functional and biological decline observed under the initial immunosuppressive therapy.
c ANCA Antibodies and Infective Endocarditis -Friends Or Foes?
Authors: Buican Luiza , Stanciu Silviu , Iordache Mihaela , Iancu Diana , Constantin Ramona , Stan Liviu , Dumitrescu Silviu , Gurzun Maria Magdalena
Published: November 2024

The differential diagnosis between granulomatosis with polyangiitis (GPA) and infective endocarditis (IE) is crucial. Both diseases show clinical similarities and serologic c-ANCA overlap. We present the case of a 45-year-old patient with inflammatory and anemic syndrome, c-ANCA positivity and initial respiratory and renal symptoms that raised the suspicion of GPA. Subsequent evolution revealed severe valve involvement and the presence of Streptococcus gallolyticus in blood cultures, confirming the diagnosis of infective endocarditis. Antibiotic treatment and surgical intervention were crucial for the patient’s recovery. This case demonstrates the importance of imaging and microbiological examinations for the correct differentiation of these diseases and the importance of a multidisciplinary approach.
Cardiac Tamponade, First Sign of Onset of Systemic Lupus Erythematosus
Authors: Anghel Daniela , Mihalca Liana-Ioana , Petrache Oana-Georgiana , Nicolau Iulia-Nadine , Mihai Ancuţa
Published: November 2024

Systemic lupus erythematosus (SLE) is an autoimmune disease with various clinical manifestations that can affect multiple organs and systems. One of the severe complications associated with SLE is cardiac tamponade, a rare and life-threatening complication. In this paper, we present the case of a 36-year-old woman who was diagnosed with SLE after an episode of cardiac tamponade. Large pericardial effusions with cardiac tamponade are rarely encountered in SLE, particularly as the onset of the disease. This case highlights the importance of early recognition of cardiac tamponade and raises awareness of the fact that SLE can present with cardiac involvement, such as cardiac tamponade, at the onset of the disease. Multidisciplinary care involving rheumatologists, cardiologists, and other specialists is essential in the management of SLE with cardiac complications.
Left Bundle Pacing for Third-Degree Atrioventricular Block in a Patient with Obstructive Hypertrophic Cardiomyopathy
Authors: Ionescu Diana Andreea , Barbu Florin , Bădilă Elisabeta , Deutsch Alexandru
Published: November 2024

Ventricular arrhythmias are common in patients with obstructive hypertrophic cardiomyopathy (HOCM) and can cause syncope and sudden death, but conduction disturbances are rarely associated with obstructive hypertrophic cardiomyopathy.

Cardiac physiologic pacing can be achieved by stimulating the intrinsic conduction system via conduction system pacing (Hiss bundle, left bundle branch-LBB- or left bundle branch area pacing). This technique can be challenging in HOCM due to septal hypertrophy. Our literature review did not find such a case reported so far where LBB area pacing was performed in a patient with HOCM with satisfying results and with the improvement of outflow obstruction of the left ventricle. Here we describe a case of a 57-year-old man with obstructive hypertrophic cardiomyopathy and third-degree atrioventricular (AV) block who presented in our cardiology department for dyspnea and fatigue. This patient was treated with LBB area pacing and recovered well.
Prosthetic restoration in frontal maxillary area using digital technologies: Case presentation (Part I)
Authors: David Mihai , Radu Elena Georgiana , Perieanu Viorel Stefan , Burlibasa Andrei , Stetiu Maria Antonia , Caministeanu Florentina , Popescu Mircea , Burlibasa Mihai , Chirila Mihaela
Published: November 2024

Digital technologies represent new alternatives in prosthetic rehabilitation of all kinds of maxillary or mandibular spans. This article is composed of two parts, in which different technological aspects will be presented regarding the prosthetic restoration of frontal maxillary areas using the CAD-CAM technology, but using different material for resistance framework, both veneered with ceramic materials to restore the aesthetics. The main materials that will be used are: Co-Cr dental alloy and zirconium dioxide (zirconia).
Exploring the Dynamics of Innovation in the Era of Artificial Intelligence
Authors: Maier Andreea , Osoian Codruța
Published: November 2024

Artificial Intelligence (AI) is revolutionizing the landscape of innovation, presenting both unprecedented opportunities and many challenges for individuals, organizations, and societies. The purpose of this paper is to investigate what will happen with innovation in an AI era, through a comprehensive analysis of the dynamics of innovation in the era of AI. Based on a bibliometric analysis we explore the paper annual publication number, the trend topic, the word count and the international interest for this subject. Through an in-dept analysis we observed some transformative changes that will arise: Data-Driven Decision Making, Personalized Customer Experiences, Supply Chain Optimization, Innovation in Financial Services, AI-Powered Entrepreneurship, Job Displacement and Reskilling, Ethical and Regulatory Considerations. By integrating insights from both bibliometric analyses and scenario planning exercises, we offer a nuanced understanding of the opportunities and challenges arising from AI-driven innovation and provide strategic recommendations for navigating the complex terrain of the AI era. The findings contribute to the academic discourse on AI and innovation, inform evidence-based decision-making, and inspire proactive responses to the transformative forces shaping our collective future.
The Impact of Social Norms on Foreign Direct Investments
Authors: Vlad Ioana Maria
Published: November 2024

This study examines the impact of social norms, measured through the Cultural Tightness-Looseness (CTL) index, on foreign direct investments (FDI) across 67 countries. I aimed to highlight a new approach from the sphere of cultural influences on bilateral FDI flows and to demonstrate the direct connection between the strictness imposed by a country’s social norms and the investment decisions based on them. The results obtained were in line with the initial expectations, validating the level of constraint/permissiveness as a truly influential factor in relation to foreign direct investments.
The Nexus Between Investors’ Sentiment and Hedge Funds Risk Premiums
Authors: Vodă Tudor-Ovidiu
Published: November 2024

In this study, we analyzed how the systematic risk of hedge funds affects different portfolio strategies. Using monthly returns data from a sample of developed market hedge funds grouped by five strategies, we identified the systematic factors influencing returns variation from January 2003 to December 2023. Market, size effect, momentum, investment effect, and bond spread were found to be the main risk factors explaining hedge fund returns dynamics. We proposed an enhanced version of the Fung and Hsieh (2004a) model, which demonstrated improved representativity with Baker and Wurgler sentiment index included as a risk premium. The quantile regression revealed that for most strategies, the estimated models performed better for the bottom quantiles.
Systemic Innovation in the European Energy Sector: A Collective Outlook
Authors: Önnered Simon , Bravić Ivona
Published: November 2024

Applying the principles of systems thinking in the evolution of energy systems is a crucial approach to meet the long-term horizons of goals in the energy sector. Through a participatory approach, this paper outlines what we view as the trends shaping the current development of the energy sector; the challenges we must face as a result, and the transitions required to tackle them. Furthermore, we discuss how systems thinking can address these challenges through changing not the components, but rather their relationships and structures. Contributing to the emerging stream of literature applying more holistic approaches to energy transitions, in contrast to more linear systems modelling. We provide innovative insights into how future energy systems could be designed to become more regenerative, resilient, empowering, whilst technologically- and economically feasible; to overcome the challenges of carbon lock-in effects and carbon capture, the rebound effects of efficiency strategies, and social sustainability for just transitions.
How to Advance Sustainable Innovations for Circular Bioeconomy: Perspectives from a Public Research Institute
Authors: Tapiola Titta , Leppälä Jarkko , Ghalibaf Maryam
Published: November 2024

This article presents a case study of public research institute innovation process for the circular bioeconomy in Finland. If an invention is to become an innovation, it requires actor alignment and cooperation from research to product development all the way to the end user. Despite the high uncertainty, the decision makers along the value chain need to identify possible directions and promising options, in addition to managing various risks. Support for these decisions is crucial to enable sustainable innovations. Furthermore, the role of public research institutions in providing “seeds” for innovations has been researched less extensively than the role of private companies or universities. This paper develops and tests a new circular bioeconomy product questionnaire to assist researchers. The questionnaire was designed for Natural Resources Institute Finland, combining risk management, new product development, and innovation process perspectives. The authors interviewed researchers and developed the framework further based on the interview analysis and tested it in a workshop. For the end product to succeed, it is necessary to understand the requirements of the entire value chain, especially the needs of end users. The research (and innovation) process should already involve stakeholders in the early stages to better meet their expectations.
Designing Sustainable Ecosystem Business Models in the Regional Context
Authors: Pellikka Jarkko , Lähdesmäki Bailey
Published: November 2024

From the perspective of innovation management, designing a sustainable business model for an ecosystem is one of the most essential aspects to ensure the realization of the value for the ecosystem members and for society in general. However, the current understanding on ecosystem business models is relatively limited. Based on the case analysis of the regional ecosystem, we provide new empirical evidence on ecosystem business models. In the case study of the water management ecosystem, we will present how it has evolved since the 1980s and what have been the key elements as part of the business model design. Based on the analysis, we see that ecosystem business models need to take into account the regional characteristics and the dynamic nature (i.e. life cycle) of the ecosystem. The results can be used to help policy makers and ecosystem members to drive value capturing via ecosystem business models.
Catalysing Action and Transdisciplinary Pathways towards Sustainable Transitions
Authors: Bühring Jörn Henning , Kimbell Lucy , Aaltonen Mika
Published: November 2024

Prelude – Special Issue Motivation
The year 2023 marked the 300th anniversary of the birth of Adam Smith, the Scottish economist whose work has impacted how we think about economic principles and the dynamics implied in politics, business, and society. Known for his seminal work “The Wealth of Nations” published in 1776, Smith argued for an economic system with little unnecessary government interference. A model built on the division of labor, guided by an ‘invisible hand’, is part of the argument for free markets directed through price mechanisms and the moral conscience of self-interested people to achieve outcomes that benefit society (Stevens, 2023). Smith’s intention to articulate a liberal economic model that prioritized contributing positively to society's welfare1 however, stands in contrast to 20th-century business doctrine, which asserted that ‘their sole social responsibility was to generate as much profit as possible for their stockholders’ (Friedman, 1962, p. 133).
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Authors: Wira Andini Luh Gede Rahma , Anom Purbawangsa Ida Bagus
Published: November 2024

Company management is responsible for managing business to achieve sustainability and increase the firm value. This research aims to determine the role of environmental performance in moderating the relationship between profitability and gross domestic product (GDP) on firm value. The population this study companies registered with PROPER on the Indonesia Stock Exchange for the period 2019 - 2023. PROPER is a company performance rating assessment program in environmental management. The sampling technique used was a saturated sampling technique,  examining the entire population, with a total sample of 84 companies. The data analysis technique uses the moderated regression analysis (MRA) technique. Based on the results of this research analysis, profitability has a significant positive effect on firm value, gross domestic product has significant negative effect on firm value, environmental performance is unable to moderate the effect of profitability on firm value, and environmental performance is unable to moderate the effect of gross domestic product on firm value. The results of this study are expected to be considered by company management and investors.
Climate Parameters and Respiratory and Cardiovascular Diseases in a Municipality of the Legal Amazon
Authors: Pereira Alice Maria de Arruda , Olinda Ricardo Alves de , Santos Débora Aparecida da Silva , Goulart Letícia Silveira
Published: November 2024

Objective: This study aims to investigate the relationship between climate parameters and respiratory and cardiovascular diseases in a municipality of the Legal Amazon in 2022. The intention is to provide data that assist in creating actions to reduce the impacts of pollution on human health.
 
Theoretical Framework: The research is based on the Theory of Climate Variability and Health and the Climate-Disease Correlation Model, which explore the relationship between climate and health. The Effects of Climate Change on Health are also discussed, providing a solid foundation for the study.
 
Method: The study is epidemiological and retrospective. Climate data (humidity, temperature, and precipitation) were obtained from a national meteorological database. Health data were collected from records of the Municipal Health Department of Rondonópolis, MT. The study period was from January 1 to December 31, 2022. The Spearman correlation test was applied.
 
Results and Discussion: Respiratory morbidities had the highest records in January (n: 1368), and cardiovascular cases were recorded in March (n: 6) and May (n: 6). There was no significant correlation between the diseases and the climate parameters studied.
 
Research Implications: It is suggested that studies consider other factors, and preventive actions be adopted during the months of highest disease incidence.
 
Originality/Value: The study provided important information about climate parameters and the distribution of cases of respiratory and cardiovascular diseases that will assist in planning prevention and control strategies.
Analysis of the quality of life in patients with multiple sclerosis within 3 years after high-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation
Authors: Polushin A. Yu. , Lopatina E. I. , Tsynchenko A. A. , Zalyalov Yu. R. , Skiba I. B. , Nikitina T. P. , Porfirieva N. M. , Ionova T. I. , Totolyan N. A. , Kulagin A. D.
Published: November 2024

Introduction. To date, data have been accumulated indicating the high effectiveness of the HDIT-AHSCT and the possibility of preserving and improving the quality of life of patients after its application.

The objective was to analyze the dynamics of quality of life using standardized assessment tools in patients with MS for 3 years after the use of HDIT-AHSCT, who participated in the program of clinical approbation of the method.

Methods and materials. The single-center observational study included 21 patients (10 women, 11 men) with a reliable diagnosis of MS, who underwent HDIT-AHSCT at the Pavlov First Saint Petersburg State Medical Universityin accordance with the protocol of clinical approbation. Distribution by type of MS course: remitting (RMS) 16 (76.2 %), secondary progressive (SPMS) 4 (19 %), primary progressive (PPMS) 1 patient (4.8 %). The assessment of quality of life (SF-36, FAMS, CSP-MS42, HADS) and severity of disability (EDSS) in all patients was performed before, 12 and 36 months after HDIT-AHSCT.

Results. Three years after the HDIT-AHSCT, a significant decrease in weakness, feelings of constant fatigue and rapid fatigue during exertion was recorded. The level of anxiety decreased in more than 50 % of patients. A direct relationship between the dynamics of clinical characteristics and the data of the scales of the SF-36 questionnaire was revealed; at the same time, after 36 months, an improvement in all parameters of the scale was noted.

Conclusion. The assessment of the indicators of the quality of life questionnaires allows us to confirm the effectiveness and significance of therapy not only from the point of view of objective clinical and radiation parameters necessary for the evidence base of the treatment method, but also from the patient’s position, which in conditions of a chronic progressive process is an integral factor for the appointment of therapeutic intervention.
Johann Caspar Lavater - Beziehungsgenie
Authors: Caflisch-Schnetzler Ursula
Published: November 2024

Johann Caspar Lavater (1741–1801) war eine der bedeutendsten Personen im Geistes- und Kulturleben des 18. Jahrhunderts. Der Zürcher Theologe und Philosoph war als Gelehrter unersättlich tätig und unerlässlich aktiv. Seine sich laufend erweiternde Korrespondenz machte Lavater zu einem Beziehungsgenie und ließ ihn zu einem geistigen und kulturellen Mittelpunkt im Europa des 18. Jahrhunderts werden – und Zürich zu einem «Limmat-Athen».Diese Biografie erschließt bislang noch unbekannte Text- und Briefquellen und zeigt so ein breites Spektrum von Lavaters Werk und Wirken. Wissenschaftlich fundiert führt sie in der Dixhuitième-Forschung zu neuen Erkenntnissen.
Crônica como dispositivo dialógico-mediacional em processos de formação profissional e pesquisa-intervenção
Authors: Cunha Gleicimar Gonçalves , Oliveira Maria Cláudia Santos Lopes de
Published: November 2024

Neste artigo, objetivou-se apresentar uma reflexão teórico-metodológica, inspirada na Psicologia Cultural, sobre o uso da crônica como dispositivo de mediação em processos de formação profissional e pesquisa-intervenção. Como ilustração, foram incorporados fragmentos de transcrições de material áudio gravado e crônicas, ambas construídas em uma pesquisa-intervenção com agentes socioeducativos de uma Unidade de Internação do Distrito Federal. Notaram-se cinco funções associadas às crônicas: recuperar a memória do grupo; apontar questionamentos favoráveis à revisão e ampliação de recursos subjetivos; agregar conhecimentos teóricos e competências analíticas; valorizar posicionamentos divergentes oportunos à revisão das crenças e relações do grupo; e elucidar aspectos implícitos da comunicação.
Asymmetry of the Trunk and Lower Extremity Joint Frontal Plane Kinematics During Single-Leg Standing and Squat in Paralympic Athletes With Upper Limb Deficiency Compared With Intact Athletes
Authors: Okamoto Shogo , Shimada Yui , Inoue Natsuka , Henderson Frederick James , Yamashita Daichi
Published: November 2024

OBJECTIVE: To compare trunk and lower extremity asymmetries in frontal and sagittal kinematics between athletes with upper limb deficiency (ULD) and intact athletes during bilateral-leg standing (BLST), single-leg standing (SLST), and single-leg squat (SLSQ).

DESIGN: Cross-sectional study.

METHODS: Eleven elite Paralympic athletes with ULD and 11 elite intact athletes performed BLST, SLST, and SLSQ. Angles of the trunk, pelvis, hip, knee, and ankle were recorded using fixed cameras in the frontal and sagittal planes. Kinematic asymmetries between groups as well as the relationship between loss of mass relative to body mass (LM%) and ipsilateral trunk tilt were analyzed.

RESULTS: Paralympic athletes exhibited greater ipsilateral trunk tilt during ULD side SLSQ (∆ = 7.1°, P = .02, d = 1.26) compared with intact athletes, but not during intact-side SLSQ. No significant correlation was found between LM% and bilateral angle differences in the frontal plane among Paralympic athletes ( P>.05, .06 ≤ | r| ≤ .27).

CONCLUSION: Athletes with ULD compensated for missing body mass by tilting their trunk over their support leg when performing SLSQ only on the ULD side. The amount of trunk tilt did not seem to depend on the amount of missing mass. JOSPT Open 2025;3(2):1-8. Epub 5 November 2024. doi:10.2519/josptopen.2024.0074
Stroboscopic Vision Decreases Performance on the Y-Balance Test in Youth Athletes
Authors: Habegger Alex , Savage Jessica , Goodrich Richard , Curtis Daniel , Traywick LaVona , Young Allison , Kahl Dana , Conrad Will , James Dawn
Published: November 2024

OBJECTIVE: To evaluate if stroboscopic vision significantly affected dynamic balance performance on the Y-Balance Test Lower Quarter (YBT-LQ) in athletes aged 12 to 18 years.

DESIGN: Single-group pretest, posttest quasi-experimental study

METHODS: Two hundred seventy-two participants aged 12 to 18 years, who participated in a school- or club-sponsored sport, performed the YBT-LQ without and with stroboscopic vision. Reach distances were recorded for each participant with and without stroboscopic vision. Main effects were analyzed to interpret the effect of stroboscopic vision on YBT-LQ performance, and secondary effects were analyzed to interpret the effect on individual reach directions and composite scores.

RESULTS: There were significant main effects between YBT-LQ scores with and without stroboscopic vision ( P≤.001). Post hoc analyses identified a significant decrease in performance when participants performed the YBT-LQ with stroboscopic vision compared to the YBT-LQ under standard conditions in each reach direction, for left and right lower extremities. There was a significant decrease in composite scores when controlling for leg length of the participants.

CONCLUSION: Performance of the YBT-LQ decreases when youth athletes’ vision is perturbed with stroboscopic vision. JOSPT Open 2025;3(1):30-34. Epub 5 November 2024. doi:10.2519/josptopen.2024.1243
Implementasi Pembelajaran Loose Part dengan Kearifan Budaya Lokal di KB Mutiara Karanggondang
Authors: Rohmatun Siti , Nofan Zulfahmi Muhammad
Published: November 2024

The introduction and utilization of local cultural wisdom from an early age are important for children's development, especially amidst challenges in early childhood education such as limited resources and lack of interest in formal learning. This study aimed to implement Loose Part learning with local wisdom at KB Mutiara Karanggondang. The results showed high levels of enthusiasm among children towards Loose Part play, demonstrating the potential of this approach in effectively facilitating early childhood development. Integrating local wisdom into learning not only enhances children's engagement but also strengthens their identity with local culture. This research also highlights the importance of culturally relevant teaching methods in the context of early childhood education, which not only enhances learning experiences but also enriches local values in their education. Thus, this study provides a substantial contribution to improving sustainable educational approaches. By combining pedagogical innovation and local cultural wisdom, early childhood education can become more relevant, enjoyable, and significantly beneficial for children's holistic development.
Рыжик — источник белка и энергии
Authors: И. ЕГОРОВ , Т. ЕГОРОВА
Published: November 2024

При вводе в кормосмесь семян рыжика и продуктов их переработки в рекомендованных специалистами дозах себестоимость комбикормов снижается, продуктивность поголовья растет, а качество мяса улучшается.
О наказании как единственно правильной и необходимой реакции общества на преступления (рецензия на монографию профессора И.М. Рагимова «Оправдание наказания. Исторические, религиозные, философские, социологические аспекты». СПб., 2024)
Authors: И.В. Велиев
Published: November 2024

Рецензия посвящена монографическому исследованию видного азербайджанского ученого и известного общественного деятеля, доктора юридических наук, профессора, заслуженного юриста Азербайджанской Республики, иностранного члена Российской академии наук Ильгама Мамедгасан оглы Рагимова «Оправдание наказания. Исторические, религиозные, философские, социологические аспекты» (СПб.: Юридический центр, 2024). Рецензент отмечает, что автору монографии удалось изучить сложнейший феномен оправдания наказания с позиций религии, философии, социологии и права и раскрыть возможность познания особенностей и закономерностей системы повышения эффективности наказания, а также обосновать наказание как единственно правильную и необходимую реакцию общества на преступления.

The review is devoted to the monographic study of a prominent Azerbaijani scientist and well-known public figure, Doctor of Law, Professor, Honored Lawyer of the Republic of Azerbaijan, Foreign Member of the Russian Academy of Sciences Ilgam Mammadhasan oglu Rahimov “Justification of Punishment. Historical, Religious, Philosophical, Sociological Aspects” (St. Petersburg: Legal Center, 2024). The reviewer notes that the author of the monograph managed to study the most complex phenomenon of justification of punishment from the standpoint of religion, philosophy, sociology and law and reveal the possibility of understanding the features and patterns of the system of increasing the effectiveness of punishment, as well as substantiate punishment as the only correct and necessary reaction of society to crimes.
Современные тенденции управления системой высшего образования и его регулирования в отдельных зарубежных странах
Authors: С.Д. Хазанов , Е.П. Коцюрко
Published: November 2024

В статье проанализированы современные тенденции управления системой высшего образования и его регулирования в отдельных зарубежных странах. Анализ зарубежного опыта демонстрирует стремление к формированию государственно-общественной модели управления образовательными организациями высшего образования, а также к поиску баланса процедур внутренней и внешней оценки их деятельности. Выявлены позитивные и негативные аспекты, которые могут быть учтены в условиях продолжающегося в настоящее время в России поиска механизмов и инструментов повышения эффективности системы управления высшим образованием и совершенствования его регулирования. Методологической основой статьи стала совокупность общенаучных методов исследования объективной действительности и познания (анализ, синтез, индукция, дедукция, описание и сравнение). Научная новизна исследования обусловлена обращением не только к моделям управления, характерным для экономически развитых стран, но и к опыту стран СНГ.

The article analyzes current trends in the management of the higher education system and its regulation in individual foreign countries. The analysis of foreign experience demonstrates the desire to form a state-public model of management of educational organizations of higher education, as well as to find a balance of procedures for internal and external assessment of their activities. Positive and negative aspects are revealed, which can be taken into account in the context of the ongoing search in Russia for mechanisms and tools to increase the effectiveness of the higher education management system and improve its regulation. The methodological basis of the article was a set of general scientific methods for researching objective reality and cognition (analysis, synthesis, induction, deduction, description and comparison).The scientific novelty of the study is due to the appeal not only to the management models characteristic of economically developed countries, but also to the experience of the CIS countries.
Развитие института судебной защиты публичных прав и свобод в Российской Федерации
Authors: Е.Х. Цагарати
Published: November 2024

В статье рассматривается проблема совершенствования судебного механизма защиты публичных прав и свобод человека и гражданина. Прослеживается история становления института защиты публичных прав граждан. Основной акцент сделан на вопросах защиты законных интересов неопределенного круга лиц. Отмечается положительная роль расширения круга субъектов, правомочных обращаться в суды в целях защиты данной категории граждан. Значительное внимание уделено раскрытию роли прокуратуры — одного из самых эффективных инструментов защиты прав неопределенного круга лиц.

The article examines the problem of improving the judicial mechanism for protecting public rights and freedoms of man and citizen. The history of the formation of the institution for protecting public rights of citizens is traced. The main emphasis is placed on issues of protecting the legitimate interests of an indefinite number of persons. The positive role of expanding the circle of subjects entitled to apply to courts for the purpose of protecting this category of citizens is noted. Considerable attention is paid to disclosing the role of the prosecutor's office - one of the most effective instruments for protecting the rights of an indefinite number of persons.
Оспаривание кредитных сделок и договоров займа по специальным основаниям, установленным законодательством о банкротстве
Authors: В.П. Быков , Е.В. Черникова , И.В. Звездова , К.И. Демишева
Published: November 2024

Представленная вниманию читателей статья продолжает цикл авторских материалов о различных аспектах правового регулирования в сфере арбитражного судопроизводства. В статье анализируются правовые основания недействительности кредитных сделок и договоров займа по специальным основаниям, установленным законодательством о банкротстве. На основе исследования арбитражной практики авторы анализируют случаи неправильного применения норм законодательства, допускаемые при признании недействительными кредитных сделок и договоров займа, совершаемых кредитными организациями.

The article presented to the readers' attention continues the series of author's materials on various aspects of legal regulation in the sphere of arbitration proceedings. The article analyzes the legal grounds for invalidity of credit transactions and loan agreements on special grounds established by the bankruptcy legislation. Based on the study of arbitration practice, the authors analyze cases of incorrect application of the norms of legislation allowed when recognizing credit transactions and loan agreements concluded by credit institutions as invalid.
SPIRITUAL, MORAL AND PATRIOTIC DEVELOPMENT OF YOUNG PEOPLE AS A FACTOR OF COUNTERING EXTERNAL THREATS OF MODERNITY
Authors: BUKSHA L. F.
Published: November 2024

He article analyses the patriotic, spiritual and moral development of young people of military age as one of the conditions for national security of Russia. The study was conducted on the territory of the Leningrad, Kaliningrad, Arkhangelsk and Murmansk regions. The total number of respondents was 1050 young men of military age (16-20 years old). The study used: the Russian version of the Moral Identity Questionnaire (O.A. Sychev, I.N. Protasova) and the modified technique “Incomplete Sentences”. It was found that low scores on the “Moral Self” and “Moral Integrity” scales are observed in 35.7% of young men of military age. They have predominantly negative ideas about the prospects for increasing patriotism among young people; they are not inclined to consider patriotism as love for the Motherland, and military service as a form of patriotism; there is a significant predominance of negative ideas about the future of the country and a lower incidence of feelings of pride for the Motherland.
VOCAL ART TRAINING AT A PEDAGOGICAL UNIVERSITY IN THE CONTEXT OF THE DEVELOPMENT OF MODERN MUSICAL THEATRE AND EDUCATION
Authors: SMELKOVA T. D. , SAVELJEVA JU. V.
Published: November 2024

The article is devoted to topical issues of teaching solo singing at a pedagogical university in connection with the development of modern musical theatre and performing tasks assigned to a singer-actor. The authors focus on the main aspects of teaching academic vocal art aimed at fostering professional singing qualities and acquiring vocal and performing culture.