bluuebunny/crossref_metadata_2025 huggingface dataset:
The behavior of population dispersion employing various numerical techniques
Authors: Imran Abbas , Asad Ejaz
Published: August 2023

The exploration of population diversity motivated us to present this paper. A mathematical model for the ecological process of population dispersion is finally considered by us to figure out the dispersion of population along the area. The dispersal from one's home site to the next is considered the most important phenomenon in the demographic and evolutionary dynamics of the population. The most important factor regarding dispersal is the spatial distribution of individuals. This dispersal may result in enhanced clamping, huge randomness, or even more spacing. The Adomian Decomposition method has opted to work out the problem analytically. Numerical schemes brought an approximate solution by incorporating the Forward-in-Time and Central-In-Space (FTCS) scheme, the Crank Nicolson (CN) scheme, and Numerov’s method. The validity and efficiency of schemes employed for the proposed model are supported by core properties like stability, consistency, and convergence. A comparison is made between the results calculated via schemes and the one analytically.
Co-immunoprecipitation v1
Authors: not provided wusj
Published: August 2023

This protocol describes a common procedure to perform co-immunoprecipitation
Immunofluorescence and live-cell Imaging v1
Authors: Wu Shenjie
Published: August 2023

This protocol contains a detail description of how to perform immunostaining on two different cell types, U2OS and iPSCs cells. It also describes how to perform live-cell imaging procedure using a Zeiss LSM900 confocal microscope in a temperature-controlled environment.
In vitro depalmitoylation assay v1
Authors: not provided wusj
Published: August 2023

This protocol describes the in vitro depalmitoylation assay of DNAJC5
shRNA knockdown v1
Authors: not provided wusj
Published: August 2023

This protocol describes a standard procedure to generate a stable cell line for a DNAJC5 knockdown using shRNA.
Immunoblots v1
Authors: not provided wusj
Published: August 2023

This protocol describes a standard procedure for protein separation and identification of protein of interest. Protocol overview: The steps of this protocol is similar for different sources of protein such as cell lysate, cytosol, or membrane samples, and EV samples. However, there are some specific changes depending on protein of interest, endogenous alpha-synuclein, or type of cells, hiPSC dopamine neurons.
Üniversite Öğrencilerinin Algılanan Kontrol Düzeyi ve Sosyal Öz Yeterlik Algılarının Psikolojik Semptomlarla İlişkisi
Authors: PALANCI Mehmet
Published: August 2023

Bu araştırmanın genel amacı, problem belirtileri ile kontrol algısı ve sosyal öz yeterlik arasındaki açıklayıcı ilişki ve bu ilişkinin düzeyinin ortaya koyulmasıdır. Bu genel amaç doğrultusunda 347’si kadın, 307’si erkek toplam 654 vakıf ve devlet üniversitesi öğrencisinden Kontrol Algısı Ölçeği (KAÖ), Sosyal Öz Yeterlik Ölçeği (SÖZYE-Ö) ve Ruhsal Belirti Tarama Listesi (SCL-90) ile veri toplanmıştır. Ayrıca karşılaştırma çalışması için 1999 ve 2002 yıllarında toplanmış bulunan 300 üniversite öğrencisine ait KAÖ ve SÖZYE ön verileri ile toplanan yeni veriler karşılaştırma yapmak için kullanılmıştır. Veri analizleri SPSS/Windows 22.0 ve AMOS paket programı ile sağlanmıştır. Veri analizinde iki farklı kaynaktan alınan ölçümleri karşılaştırmak için t testi kullanılmıştır. Ölçek geçerlik ve güvenirlik analizleri için SPSS AFA ve AMOS DFA analizleri kullanılarak (kullanılmıştır şeklinde cümle bitirilirse cümle yapısı daha uygun olur) Analizler sonucunda kontrol algısı (KA) ile sosyal öz yeterlik (SÖZYE) arasında pozitif orta düzey korelasyon belirlenmiştir. Ayrıca psikolojik belirtiler (PB) ile KA ve SÖZYE arasında anlamlı negatif korelasyon izlenmiştir. Bunun yanı sıra sonuçlar, KA’nın PB üzerindeki etkisinin doğrudan ve SÖZYE aracılığı ile dolaylı olduğunu göstermektedir. Son olarak aradan geçen sürede üniversite öğrencilerinin kontrol algılarının anlamlı düzeyde değiştiği ancak sosyal öz yeterlik düzeylerinin değişiminin istatistiksel olarak anlamlı düzeyde olmadığı görülmüştür.
Thinking Outside of the Jazz Square
Authors:   , Ault Natalie , Yau Pamela
Published: August 2023

Experiential marketing has become a popular marketing tool that allows fans to become part of the marketing experience on a level that traditional advertising does not. It also allows for companies to capitalize on the experiential events for years to come by creating content for platforms like Facebook, Twitter, Instagram, and TikTok. Many large brands have embraced the concept of experiential marketing as it often provides a duplicate opportunity for promotion, as the day of the event can be shared repeatedly on social media. However, one area has been hesitant to embrace experiential marketing - Broadway shows. Despite being one of America's oldest art forms and a popular form of entertainment, many Broadway shows have not joined the experiential marketing trend. There are many reasons why this might be the case, the largest being the fact events are often cost prohibitive and Broadway shows have smaller budgets in comparison to larger consumer-based products. Through quantitative research from studies that are currently available on the subject as well as considering the concept of social exchange theory and through five in-depth interviews, this thesis presents a look at the Broadway marketing sphere today and how experiential marketing can help navigate its future.
Evaluation of the protective role of antioxidants: α-tocopherol, vitamin C, and quercetin, against ibuprofen-induced renal damage in male Wistar rats
Authors: Okoroama Casmir E. , Unekwe Prince C. , Okoroama Linda C. , Okparaoka Samuel U. , Akuodor Godwin C.
Published: August 2023

Background: Ibuprofen, commonly used in management of pains and inflammatory conditions, has been associated with renal damage. The protective role of antioxidants against Ibuprofen-induced renal damage in wistar rats were investigated in this study.
Methods: The study was designed in two parts; first, to induce kidney damage and secondly, to determine protective role of antioxidants against ibuprofen-induced kidney injury. In the first phase, two groups of animals were used; one group treated with 120mg/kg ibuprofen daily for 14 days, while the other served as control and had distilled water. Serum malondialdehyde and kidney parameters were estimated after treatment and kidneys harvested for histology. In the protection study, animals were divided into five groups, with groups 1-4 having three sub-groups treated with 120mg/kg Ibuprofen and graded doses of vitamin E, vitamin C and quercetin respectively, while group five served as control. After 14days, antioxidant enzymes and kidney parameters were estimated, and the kidneys harvested for histology.
Results: Showed significant (p<0.05) increase in malondialdehyde, urea, creatinine, and uric-acid levels after ibuprofen administration. Conversely, there was significant (p<0.05) reduction in kidney parameters after co-administration of antioxidants with ibuprofen, with significant increase in antioxidant enzymes. Estimated antioxidant’s percentage protection showed vitamin E gave highest protection on the kidneys against ibuprofen-induced damage amongst others. Histology revealed atrophied glomeruli with widened capsular space, desquamated tubular epithelial cells and infiltrating lymphocytes after ibuprofen administration, but showed normal histo-architecture after co-administration with antioxidants.
Conclusion: Antioxidants such as α-tocopherol, vitamin C, quercetin, protected against ibuprofen-induced renal damage in Wistar rats.
A comparative study on the dependence potential of thienorphine and buprenorphine
Authors: Yong Zheng , Li Yu-Lei , Zhou Pei-Lan , Gong Ze-Hui , Su Rui-Bin
Published: August 2023

Background: As part of research to discover partial opioid agonists for new treatments of opioid abuse and dependency, thienorphine, a buprenorphine analogue, was synthesised and reported to be a potent, long-acting oripavine in multiple mammalian models. Thienorphine binds non-selectively to μ-, δ-, and κ-opioid receptors, and partially stimulates μ- and/or κ-opioid receptors in vitro. Compared with buprenorphine, thienorphine exhibits better analgesic effects and has higher oral bioavailability. Poor oral absorption and dependence have hindered the use of buprenorphine for detoxification therapy and relapse prevention in the clinic. The addiction potential of thienorphine is unknown, and is worthy of in-depth investigation.
Methods: In the present study, we conducted a comparison of thienorphine and buprenorphine with respect to their physical and psychological dependence liabilities, using a naloxone-induced withdrawal test, a conditioned place preference test, and a self-administration experiment in rats.
Results: In contrast to chronic buprenorphine administration, we failed to observe any severe abstinence syndromes in mice or rats treated with thienorphine after naloxone challenge in a physical dependence model. Compared with the dependence potentials of buprenorphine, rats treated with chronic thienorphine did not show a place conditioning response, self-administration, or psychological dependence.
Conclusions: We demonstrated that thienorphine has a lower potential than buprenorphine for physical and psychological dependence. Our results indicate that thienorphine might be a good candidate to treat opioid addiction.
Evaluation of drug treatment awareness among caregivers and patients of chronic kidney disease: unexplored determinant in patient care
Authors: Tripathi Raakhi K. , Pilliwaer Chailtali , Gajbhiye Snehalata , Bhilwade Sujeet K. , Jamale Tukaram
Published: August 2023

Background: Chronic kidney disease (CKD) patients are prescribed multiple drugs to slow disease progression and prevent complications mandating adherence to therapy. Lack of awareness about drug treatment is one of the contributors to nonadherence. Hence the study was conducted to explore the awareness of patients and caregivers towards CKD treatment.
Methods: The study was a cross sectional questionnaire-based study conducted among 300 CKD patients (150 dialysis/150 non-dialysis) and 100 caregivers (50 of dialysis / 50 of non-dialysis patients) attending nephrology OPD at a tertiary care hospital.Patient /caregiver awareness about drug treatment was assessed usinga prevalidated drug awareness questionnaire (8 items). The items were scored as correct response=2, no response=0 and incomplete response = -1, accounting the total awareness score as +20 to - 6
Results: The mean awareness score of patients / caregivers was 8.16±3.41 and 8.3±1.6 respectively. Majority (>70%) patients/ caregivers gave accurate responses for the items -specifying number of medicines, medication frequency and regular intake of drugs but awareness regarding action plan for skipped (27% patients, 11% caregivers) or missed doses (22% patients, 15% caregivers) and adverse effects (17% patients, 5% caregivers) was poor. Patients/ caregivers belonging to dialysis group had statistically better awareness then non-dialysis group.
Conclusions: Patient /caregiver awareness regarding drug treatment is less than 50% with strikingly low awareness about dose regimen, adverse effects, action plan for missed doses and co morbidities. Patient education programs to reinforce and retain this knowledge need to be implemented in CKD patients.
A prospective observational study of prescription pattern of antihypertensive drugs in general medicine outpatient department of associated hospital RUHS CMS, Jaipur
Authors: Sharma Vishal , Sharma Beena , Rathore Rajveer Singh , Sharma Lokendra
Published: August 2023

Background: The increasing prevalence of hypertension is attributed to population growth, ageing and behavioural risk factors, such as unhealthy diet, harmful use of alcohol, lack of physical activity, excess weight and exposure to persistent stress. The aim of study is the prescribing pattern and the consumption of antihypertensive drugs in isolated hypertensive patients and in hypertensive patients with different co-existing morbidities.
Methods: The present study is a Prospective observational study. The study was conducted at Medicine Department of associated hospital of RUHS College of Medical Sciences, Jaipur.
Results: A total of 965 patients having hypertension were analyzed, in that 556 patients were male and 409 patients were female. In hypertension patients, angiotensin receptor blockers ARB, diuretics and β- blockers (29.90%) were mostly used classes in three drug therapy. Whereas telmisartan, hydrochlorothiazide and metoprolol (35.05%) were mostly prescribed. Drugs. In hypertension patients, angiotensin receptor blockers ARB, diuretics, β- blockers and calcium channel blockers (56.67%) and calcium channel blockers, angiotensin converting enzyme inhibitors, β-blockers and diuretics (43.33%) were used classes in four drug therapy. Whereas Telmisartan, Hydrochlorothiazide, Nebivolol and Amlodipine (62.5%) were mostly prescribed drugs. Hypertensive Patients with Comorbidity were found in higher prevalence with 276 hypertensive patients (28.60%) along with Diabetes Mellitus most commonly found and 389 hypertensive patients (40.31%) were found to be with No Comorbidity.
Conclusions: Present results reveal that antihypertensive medication adherence to JNC-8 recommendations is suboptimal. Therefore, physicians should follow JNC-8 guidelines to improve the patients care because suboptimal adherence leads to adverse clinical outcomes. The present study demonstrated that physicians are not completely adhering to standard guidelines while treating hypertension with co-morbid conditions.
Ketamine but not glycine potentiates antidepressant like action of citalopram in mice exposed to chronic mild stress
Authors: Verma Veena , Sanone Pankaj P. , Mehta Ashish K. , Tripathi Chakra D.
Published: August 2023

Background: The present study was designed to investigate the effect of citalopram, ketamine, glycine and their combinations on animal models of depression.
Methods: Swiss Albino male mice were subjected to chronic mild stress for 6 weeks for inducing depression, and randomly divided into different groups: citalopram (5 and 10 mg/kg), ketamine (17.5 and 35 mg/kg), glycine (50 and 100 mg/kg), ketamine (17.5 mg/kg) + citalopram (5 mg/kg) and ketamine (17.5 mg/kg) + glycine (50 mg/kg). Two behavioural tests were utilized for the assessment of depression, namely tail suspension test (TST) and forced swim test (FST). Immobility time was recorded for 6 min, before and after administration of drug.
Results: Citalopram (10 mg/kg) administration caused significant decrease in the immobility time in TST model only but not in FST. Citalopram (5 mg/kg) and ketamine (17.5 mg/kg) caused insignificant decrease in immobility time in both the models. Moreover, ketamine in combination with Citalopram significantly reduced the immobility time in both the models. Glycine at a dose of 100 mg/kg (but not 50 mg/kg) significantly increased the immobility time in both the models as compared to control group. Further, ketamine when administered with glycine caused increase in the immobility time on both the paradigms, though insignificant.
Conclusions: Ketamine demonstrated antidepressant like action in both TST and FST models. Moreover, it potentiated the antidepressant effect of citalopram that might be due to the role of NMDA receptors.
Anaphylaxis to oral misoprostol in a term pregnant patient who is non-allergic to vaginal misoprostol-a case report
Authors: V. K. Vineeth , Jose Maria
Published: August 2023

Misoprostol (PGE1) is a drug that is very commonly used in obstetrics for labour induction. Apart from its side effect of causing congenital malformations in offspring of users who have unsuccessfully used it as an abortifacient, it is considered a safe drug with few side effects. We here report a severe hypersensitivity reaction to misoprostol in a 33-year-old term pregnant patient who is non-allergic to vaginal misoprostol. The patient developed anaphylactic features like swelling of lips, low voice due to laryngeal oedema, and bradycardia. Prompt administration of adrenaline and emergent caesarean section allowed for the safe delivery of the neonate. When inducing labour, quick identification and treatment of anaphylaxis and hypersensitivity reactions are necessary to prevent maternal and neonatal morbidity and mortality.
How ‘pill for every ill’-alarming source of polypharmacy in elderly patient
Authors: Pandey Saumya , Choudhary Reshma
Published: August 2023

According to WHO there is one elderly person i.e., age 60 year or older in every nine people and this value is expected to increase by 2050 accounting for about half of the total growth of the world population. This demographic transition poses a significant challenge for health care authorities as the age advances multiple chronic disease such as hypertension, DM, arthritis, chronic heart disease, renal disease come in to scenario. For the above-mentioned disease an elderly patient has to take life-long medications this leads to polypharmacy.
Relationship between zinc levels, anthropometric parameters and socio-demographic status among primary school pupils in a semi-urban community in Nigeria
Authors: Oladibu Olanike , Kofoworade Olawumi , Onigbinde Michael , Ojedokun Samson , Alabi Ayobami
Published: August 2023

Background: Zinc plays important roles in many biological processes in the body such as acting as a catalyst for numerous enzymes involved in nucleic acid metabolism cellular replication tissue repair and the growth of tissues hence, the study was aimed to determine the relationship between zinc levels, anthropometric parameters and socio-demographic status among primary school pupils.
Methods: The study was a cross-sectional descriptive design carried out among four hundred primary school pupils between the ages 6-12 years in Ogbomoso. Questionnaires were distributed to obtain socio-demographic information from pupils and blood was collected for serum zinc analysis using ELISA technique. The data obtained were analyzed using Statistical Package for Social Sciences (SPSS) version 21
Results: The level of serum zinc deficiency in the study population was 9.5%. Serum zinc levels are significantly higher among younger age groups compared to older age groups (F=6.913, p value=0.001). The family size and socio-economic class are significantly associated with zinc levels. Zinc level was significantly lower in underweight children (0.389±0.25) compared to normal weight (0.819±0.39), overweight (0.991±0.62) and obese children (0.654±0.41), F=7.264, p=0.001
Conclusions: Zinc deficiency is an important component of nutritionally related morbidity worldwide. Zinc supplementation or food fortification among school children will have beneficial effects on the incidence and outcome of serious childhood infectious diseases.
Association of lung function by spirometry with serum ferritin in transfusion-dependent thalassemia patients in a tertiary care centre
Authors: Ahmed Arif , Sahu Yatendra , Meena Dinesh , Bairwa A. L.
Published: August 2023

Background: β-thalassemia major is an inherited, transfusion-dependent chronic anemia which is caused by decreased production of β-globin chains required for formation of hemoglobin. Regular blood transfusion is most important factors that help in improving the survival of patients with TM; however, it leads to iron deposition in many organs such as lung. Most studied concerned about effect of iron on lung functions, revealed abnormalities, but limited data were observed. The aim of our study was to determine pulmonary function abnormalities in children with thalassemia major and assess the relation between these abnormalities and iron overload.
Methods: This study had included 51 children in each group, aged between 6 and 18 years (28 males and 23 females) with TM. All included children were subjected to full clinical examination and laboratory investigations including complete blood counts and serum ferritin. Pulmonary function tests (PFTs) were assessed in all included children using spirometry.
Results: 31.4% patients had restrictive lung functions. Spirometer parameters i.e., FEF25-75% (p value≤0.0001) and PEFR (%pred) (p value≤0.0001) had significant difference in both groups. FEF25-75% and PEFR had no effect of serum ferritin.
Conclusions: The lung may be considered a site for organ damage, and alteration of pulmonary function may be expected in transfusion-dependent patients in spite of no pulmonary symptoms or normal chest X-ray.
Study of etiological factors and immediate outcomes of neonatal seizure among preterm and term neonate in a tertiary health centre of Northern India
Authors: Yadav Surbhi , Agrawal Payal , Sharma Vinod K. , Rekha  , Yadav Sunder Lal
Published: August 2023

Background: Neonatal seizures result due to altered neurological functions like motor, behavioural and autonomic function. We conducted this study to assess the incidence, etiological factors, and immediate outcomes of neonatal seizures in term and preterm neonates.
Methods: This prospective observational study included all neonates delivered in a tertiary health centre of New Delhi from Nov 2015 to Oct 2016 and admitted in Neonatal Intensive Care Unit with clinically identified seizures up to 28 days of postnatal age.
Results: Out of 11,109 live births during the study period, 302 developed neonatal seizures with overall incidence of 2.71%. The early preterm (12.05%), very low birth weight babies (56.30%), and neonates in first 24 hrs of life (68.9%) had the highest incidence of neonatal seizures. The commonest seizure type was subtle seizures (52.3%). In early preterm commonest etiology was infection (31.3%) while in late preterm and term neonates most common etiology was Hypoxic ischaemic encephalopathy 59% and 72% respectively. Overall, HIE was the most common etiology (57%). Out of 302 cases, 81 (26.8%) cases have died. HIE was found to be the most common cause for mortality. Mortality was highest in early preterms (49.3%) and very low birth weight neonates (52.3%). Also, mortality was maximum among neonates having subtle seizures (29.1%) and seizures occurring within 24 hrs of life (30.8%).
Conclusions: Persistently high incidence of neonatal seizures requires further strengthening of antenatal, natal, and post-natal health services. Early identification of neonatal seizures and timely intervention are very important for better outcomes.
Comparison of umbilical cord blood lipid profiles between appropriate and small for gestational age newborns with their mothers’ lipid profiles: a case-control study from tertiary care centre of Karnataka
Authors: Machakanur Vishwanath L. , Nayak Narayan V. , Undi Malatesh
Published: August 2023

Background: Fetal malnutrition and fetal growth restriction results in dysfunctions of neuroendocrine system, pancreas and adipose-tissue; finally increasing the food intake and decreasing energy use. This results in an increase in adipose deposition and insulin-resistance and ultimately increasing chances of adult metabolic-diseases. This study makes an effort to compare and contrast the lipid-profiles of Small for Gestational Age (SGA) and Appropriate for Gestational Age (AGA)newborns correlating and with their mother’s lipid-profiles.
Methods: This was a case-control study, conducted in the Departments of Pediatrics and OBG of Karwar Institute of Medical Sciences,Karwar, Karnataka,India over a period of twelve months(January-2021 to January-2022). With 500neonates, 357appropriate for gestational age (AGA) and 143 small for gestational age(SGA) babies were included for the study as controls and cases for their lipid profiles using their cord-blood.
Results: here, we found that SGA-babies had lower gestational age (37.40±1.01 weeks) at birth compared to AGA-babies (39.22±1.05 weeks) which was statistically significant. The mean Total Cholesterol (TC) level (84.47±27.39 mg/dl) was higher in SGA-babies compared to AGA-babies (56.87±32.28 mg/dl) and this difference was statistically highly significant (p value<0.0001). The mean very low density lipoprotein (VLDL) level (14.10±10.67 mg/dl) was higher in SGA-babies than AGA-babies (7.17±3.69 mg/dl) with p value<0.0001 (highly significant). The mean low density lipoprotein (LDL) level (38.74±19.85 mg/dl) was higher in SGA-babies compared to AGA-babies (25.63±14.15 mg/dl) and this difference was statistically significant (p value<0.0001). The mean high density lipoprotein (HDL) levels of AGA and SGA-babies were comparable with low statistical significance (26.70±14.90 mg/dl of SGA; 24.45±9.567 mg/dl of AGA, p value 0.095).
Conclusions: Levels of all lipids were observed to be higher in SGA babies than in AGA babies. Mothers who gave birth to SGA babies were found to have statistically significant high VLDL levels.
Bone marrow necrosis in paediatric patients: a diagnostic dilemma
Authors: Bhati Sonal , Bhatia Gunjan , Meena Seema , Rathore Ritul
Published: August 2023

Bone marrow necrosis (BMN) is regarded as an infrequent and rare pathological finding in the aspirates and the trephine biopsies. It is a rare histological finding which may be associated with infections, sickle cell disease, leukemia and other diseases. Its postmortem prevalence ranges from 0.3% to 2.2%., BMN might also be seen prior to, or following a diagnosis of neoplasia, ordering subsequent treatments with chemotherapy or radiotherapy. Cellular elements can be masked by the extensive necrosis, leading to a non-diagnosis and can also precede the disease pathology before its presentation, which can lead to delay in accurate diagnosis. This study was done to highlight the rare findings of BMN and to scrutinize the underlying disease producing BMN after evaluating medical history, clinical presentation, laboratory findings and morphological analysis of bone marrow aspirations and biopsy. A cross-sectional observational study was done for a period of 3 years and this rare finding was observed only in five cases. This study indicates that the conditions associated with BMN are varied and malignancy remains common. BMN may precede or obscure the diagnosis, and repeat biopsies are indicated to secure a diagnosis. Pyrexia, bone pain, pancytopenia, elevated LDH and alkaline phosphatase levels are common associates of BMN.
Interesting surgical cases of mesenteric cystic lymphangioma
Authors: Glutkin Aleksandr V. , Khartanovich Veronika V. , Patel Grishma R.
Published: August 2023

Mesenteric cystic lymphangioma involving the gastrointestinal tract is uncommon in infants and children. It is a benign tumor due to abnormal formation lymphatic system. These tumors exhibit symptoms varying in site and size of localization. Usually, symptoms are manifested by acute abdominal pain, intestinal obstruction, rising body temperature, and diarrhea. Lymphangioma can easily misdiagnose with other conditions like intestinal obstruction, acute appendicitis, or ovarian cyst in a female child. Therapeutic interventions such as fibrin glue, steroids, bleomycin, OK-432, and laparoscopic-assisted surgery are available. From 2018 to 2022, the Regional Paediatrics Hospital of Grodno, Belarus has recorded two cases of mesenteric lymphangioma. Both were emergency cases. In this scientific paper, we have described a surgical approach with improved outcomes. In both cases, surgical resection of lymphangioma that was rooted alongside the ileum was done. We used laparotomy in our surgical procedure, however, the approach was different, one being lower median laparotomy and another being a transrectal approach. Post-operatively patients were in satisfactory condition. Even though mesenteric lymphangioma is a benign condition, it should be immediately diagnosed and surgically managed to avoid morbidity, and mortality due to an increase in size that can fatally compress the adjacent organs impairing the function of an organ and complications like intestinal obstruction and bleeding. Our approaches with case-1 and case-2, both resulted in effective surgical and post-surgical outcomes. But more data is required to make a population-based influence depending on our approach.
Not uncommon but often under-recognized: case report of fixed drug eruption in a child
Authors: Lexminarayana Kaysha-Lin , Chin Ming Lee , Ng Su Yuen
Published: August 2023

When re-exposed to the offending drug, fixed drug eruptions (FDEs), a distinctive type of mucocutaneous drug reaction, typically recur in the same places. Often, these eruptions are benign in nature, however the recurrence and appearance of these lesions may be a cause of worry to patients, and in the pediatric population, to their caretakers as well. Lack of awareness among clinicians coupled with suboptimal history taking pertaining to drug usage are the key factors leading to delayed and under-diagnosis of FDEs. We discuss the case of a child whose fixed drug eruption was misdiagnosed as an insect bite for more than a year. This led to parental anxiety, as well as trial of multiple avenues of treatment to no avail. This article aims to raise awareness of the importance of prompt recognition of FDEs, as identification and discontinuation of the offending drug will alleviate the eruptions and prevent recurrence of the condition.
Challenges faced in management of a neonate with ambiguous genitalia
Authors: Samuel Steeve Gnana , Bharathi S. Mangala
Published: August 2023

A neonate born with atypical sex development presents with challenges to the clinician as well as parents. There are challenges in diagnosis, gender assignment, initiating and adherence to treatment, follow up, counseling and prenatal diagnosis and counselling. There are uncertainties in the time of prenatal diagnosis as well. The objective of this case report is to highlight the challenges faced by a parent of a neonate with ambiguous genitalia.
Cockayne syndrome: an uncommon clinical entity
Authors: Bhupathi Meghana , Vittal C. S. N. , Mediboina Anjali , Rachakonda Sai T. , Aijaz Ayesha
Published: August 2023

Cockayne syndrome is a rare autosomal recessive genetic disorder characterized by microcephaly, failure to thrive, and delayed development. It is associated with an abnormally small head size, stunted growth, and a high incidence of <1 in 250,000 live births. The clinical presentation of Cockayne syndrome varies widely, making diagnosis challenging, particularly in Southern India where limited data is available on its neurological manifestations. This case report describes a 23-year-old male patient presenting with neurological symptoms, highlighting the need for increased awareness and early detection of Cockayne syndrome in this region.
The pediatric dentistry management pyramid: a new model for patient care
Authors: Setty Jyothsna V. , Shetty Vidyullatha V. , S. Shilpa , I. Srinivasan , Jaikrishna Aparna
Published: August 2023

Successful performance of a treatment procedure on a child patient in dental office is often dependent on multiple determinants.  Here is the compilation of all the factors, which is represented in the form of a pyramid shaped model.  Child, the focus of interest is at the apex or the tip of the pyramid.  The square based pyramid with the four corners as parents, society, dentist and e-screen form the important determining variables in the successful management of the child patient. Five layers of this pyramid depict the interactions and summarize the various factors involved and the level of importance in the management of the child.  The most important contributor assumes the topmost position in the pyramid while the others taking the supporting roles in the sequential order towards the base.
Assessment of nutritional components and nutraceutical benefits of millets: An integrative review
Authors: Ahirwar Narendra Kumar , Ravindra Singh
Published: August 2023

Despite being a lesser-known group of cereal grains, millets boast a rich nutritional and nutraceutical profile. Often mischaracterized as sustenance for the underprivileged, millets provide an impressive array of nutrients, rivalling many mainstream cereals. Notably, they offer substantial amounts of energy, carbohydrates, and protein, and even surpass other cereals in their content of fats, calcium, iron, dietary fiber, and Vitamin E, including both tocopherols and tocotrienols. Their remarkable phytochemical composition, which includes phenolic acids, flavonoids, catechins, phytic acid, and phytosterols, has captured the attention of researchers. It's been documented that the dietary fiber and phenolic compounds present in millets are instrumental in mitigating various health ailments, including diabetes, cardiovascular issues, and cataract development. These phytochemicals are also recognized for their antioxidant and antimicrobial attributes.
Combined spinal-epidural anaesthesia in a high-risk abdominoplasty - A case report
Authors: Phalgune Deepak , Mahadik Shripad , Sushmitha K
Published: August 2023

Abdominoplasty is generally performed with admission of the patient for one night. It is a usual beautifying technique. It is reported that abdominoplasty can cause death and morbidity. For performing abdominoplasty numerous anaesthesia techniques are reported. Morbidly obese patients with compromised heart ailment undergoing abdominoplasty pose exceptional challenges to the anaesthesiologist. It is necessary to use the anaesthetic procedure such that it causes minimal haemodynamic instabilities with supreme safety for the patient. In this case report a 53-year-old male, morbidly obese patient with a body mass index (BMI) of 43.8 Kg/m, belonging to American Society of Anaesthesiologist (ASA) grade IV, and overhanging abdomen till the level of knee, with ventricular bigeminy, severe pulmonary hypertension, obstructive sleep apnea and chronic kidney disease is described. Abdominoplasty of this patient was performed under combined spinal-epidural anaesthesia. The implications of combined spinal-epidural anaesthesia were that the hemodynamic parameters such as heart rate, respiratory rate, non-invasive blood pressure, SpO2 were stable during the procedure and no complications were observed post-operatively. The results were excellent with speedy recovery.
A case report: Anaesthetic management of a patient with sub acute intestinal obstruction with chilaiditi syndrome coming for surgery
Authors: Balasubramanian Ashok Kumar
Published: August 2023

Chilaiditi syndrome is associated with hepatodiaphragmatic interposition of the colon and the small intestines. The radiological finding of colonic interposition between the liver and diaphragm is called chilaiditi sign. This is a rare anomaly incidentally seen on chest or abdominal radiographs. We present a case report of a 52 year old male who got admitted with complaints of abdominal distension and occasional pain after food intake for 5 months duration. The pain was dull aching and not radiating. He gave history of weight loss of about 10 kg over 5 months. His mother had similar complaints of dull aching abdominal pain of which she died. X ray chest showed gross dilatation of descending and transverse colon causing mediastinal shift to right. The CT chest showed emphysematous bullae on the left lobe. The working diagnosis of Chilaiditi syndrome was made. The patient came for surgery with subacute intestional obstruction. Here, in this case report we discuss the anaesthetic management.
Anaesthetic management in patient with left ventricular clot posted for non-cardiac surgery
Authors: Balasubramanian Ashok Kumar , Ravikumar Dhivya
Published: August 2023

Cardiovascular disease remains the leading cause of mortality all over the world. Mortality from acute myocardial infarction (AMI) has decreased since the introduction of primary percutaneous coronary intervention (PCI). Left ventricular (LV) thrombus is a common complication after acute myocardial infarction (MI). One of the most feared complications is the occurrence of thromboembolic events (mostly cerebrovascular accidents) due to left ventricular (LV) thrombus formation. We present a 65 yrs old male with right traumatic foot ulcer, scheduled for right foot SSG. His ECG showed anterior wall ischemic changes. Echocardiogram showed akinetic LV apex, EF: 47%, with an organised LV apical clot of 1.5×1.4cm. Cardiologist opinion was obtained and he was put on oral nitrates, beta blocker and statins. Surgery was done under right popliteal sciatic nerve and fascisa iliaca block. Intraoperative period was uneventful. Postoperatively, serial ECG and Trop I was done on 1 and 4 POD and was found to be normal. He was discharged on 4 POD, with advice to follow up with cardiologist.
Applying lean principles to innovation management
Authors: Ivanov Dmitriy Yu. , Savin Alexei G.
Published: August 2023

The innovative potential of the organization is increasingly becoming one of the key factors of competitive advantage. The philosophy of lean manufacturing has a well-established reputation for its focus on process efficiency and is therefore often applied in various areas of innovation. This broad and growing applicability has resulted in a large body of literature on lean innovation. The purpose of this article is to conceptualize an integrative view of Lean Innovation Management. Based on a systematic review of the literature, key principles and practices of lean manufacturing that are useful in the context of innovation management are identified and combined into a comprehensive framework. Five aspects of lean innovation are identified: coaching, learning culture, collaborative organizational structure, collaborative external networks and learning procedures), which reflect the structure of the relationship between lean manufacturing and innovation. Contributing to the current socio-technical concept of lean, this study brings together the literature into a comprehensive framework of cultural, relational, organizational, technical, and leadership qualities. Future research may focus on the Lean Innovation Management transformation process and how it can be monitored and evaluated according to management maturity levels or organization development stages.
Battery Technology – A Comprehensive Review
Authors: H Arun Kumar , N Varun Kumar Reddy , S H Manjunath , V Shamanth
Published: August 2023

Depletion of fossil fuels, stringent pollution norms have made a way for research on the systems that can store energy from renewable sources like solar and wind. Electrical vehicles (EVs) and hybrid vehicles (HEVs) density worldwide are increasing at faster rate and have projection estimate of more than 140 million (HEVs) and EVs on the road by 2030. Design of these advanced engines are based on the availability power source namely lithium-ion (Li-ion) battery. This paper focuses on available battery technologies, components of Li-ion batteries, key features of the battery such as energy density, power density and so on and opportunities of recycling, extraction of valuable metals from the waste batteries are also included.
Requirement Politics
Authors: Bowen Bernadette
Published: August 2023

In this article, which includes a feminist micro-chapbook, the author has chosen poems written both prior to and following their recollection of and subsequent therapeutic struggle to work through their lifelong experiences of sexual harassment and assault. Situated within the neoliberally co-opted #MeToo campaign, Betsy Devos’s 2020 Title IX cross-examination mandate, and post-Trumpian, ongoing COVID U.S. landscape, this work performs an ethnographic autopsy on the body politic: displaying the fleshy lived consequences of an unjust legal system. By continuing Faulkner’s work on poetic inquiry as feminist methodology, this piece contributes to the tradition of poetic praxis as a means of clapping back to structures of oppression. At its core, this article reveals relived experiences and words spoken by institutional figures reluctant to fulfill mandatory reporting requirements. By playing off Higginbotham’s (1993) term respectability politics, “Requirement Politics” blurs lines of academic and poetic writing to deliberately collapse a fabricated line between public and private lived experiences.
Lingering in Leggoian Light
Authors: Rajabali Anar
Published: August 2023

My PhD supervisor and mentor, Carl Leggo, died of cancer on March 7th, 2019. In this essay, I trace the personal, poetic, intellectual, and spiritual journey of his momentous mentorship. In the absence of his physical being, there is still a profound presence, and what I have come to know as pedagogical light. On his passing, another lyrical lesson began for me on how what a teacher leaves behind can stay in the mind, heart, and soul for a lifetime. I have emerged knowing what it means to live poetically, as Carl was writing and teaching us all along. His mentorship is enduring and continues to shape the art of my own being into fullness as a poet, (re)searcher, and teacher. Here, through prose and poetry, I reflect on Carl’s wisdom and how he saw the breadth of my pedagogical being—the whole of the moon.
A Review of Teachers and Teaching On Stage and On Screen
Authors: Mortimer Amy
Published: August 2023

This piece is a review of Teachers and Teaching on Stage and on Screen: Dramatic Depictions, edited by Diane Conrad and Monica Prendergast (2019). Mortimer’s personal poetic response opens the review to honour her artistic ways of knowing and responding to the content. The book’s contributing authors, all educators, provide diverse cultural, social, and socio-economic perspectives and insights into how teachers and teaching are represented in film and on stage. Conrad and Prendergast’s book invites a range of audiences (from pre-service teachers to academics) to reflect on dramatic depictions of teachers and to use them to deepen understandings of the complexities of teaching, schooling, and students—and, if readers are teachers themselves, to examine their own practice.
Intersectionality Gets Fashionably Fat
Authors: Friedman May , Evans Calla , Barry Ben
Published: August 2023

The authors’ research project, Sizing Up Gender, explored the experiences of thirteen participants at the intersections of gender expression and fat. Through a series of photographs of participants and their garments, the project pushed the boundaries of art, identities, representations, and research. This article seeks to consider the ways in which innovative arts-based practice with a deep focus on justice and anti-oppression can allow for a thickening of intersectionality research. The blending of art and research practices, such as those under discussion here, can simultaneously maintain a commitment to the genesis of intersectionality’s critical potential while allowing the term to evolve and consider heretofore undiscussed terrain.
"I Have a Bag of Old Knickers. Do You?"
Authors: Mendus Alys
Published: August 2023

This article presents audio found poetry as an approach which positions participants’ voices in the heart of the inquiry. The methodology was influenced by radio autoethnography and audio papers where theory, voices, and sound are combined to create a new aural experience—an approach that argues that it is essential that the audience listens rather than reads. These two audio found poems share the voices of 14 participants from Australia, United Kingdom, North America, and Mainland Europe, interwoven with the author, talking about their relationship with underwear. Participants recorded their own story. Each voice was edited using Audacity (a software program) and then different voices were joined together. Two poems emerged. Audio 1: Practical Underwear shares stories from day-to-day underwear preferences and stories of those who do not wear underwear. The stories in Audio 2: Dress Code Red are connected to sexuality and political aspects of underwear. Framing the work through the lens of new materialism creates a space of agency for an entanglement between the underwear and the human voices speaking about it, which in turn affects the embodied experience of the listener. What stories could your underwear tell?
Making With Place
Authors: Lombardo Charlotte , Novak Phyllis , Flicker Sarah , Making With Place Artists
Published: August 2023

Making With Place explores expressions and desires of queer, Indigenous, and racialized young artists on place, community, and culture. During the height of the COVID-19 pandemic (from spring 2020 to fall 2021) community-based researchers engaged in participatory arts processes with young artists, culminating in public art installations theorising evolving inquiries and ideas into place. In this paper, we showcase six artworks to exemplify three conceptions of place that emerged from this collective work: (a) place holds histories; (b) place is relational; and (c) place as a verb. We consider how learnings from this project can help to more equitably reclaim public space through (re)mapping and (re)visioning as living processes of place-making. Community arts, in public space, can inform how we create, investigate, and make place through the arts. Who does this inviting, and who is ultimately assembled, is of vital importance. Place is where we encounter each other.
Shame and Disavowing Queer Reality
Authors: Forrest Michelle , Joy Phillip
Published: August 2023

Stigma has been defined as a spoiled identity, a branding that sets a person outside the norm, with potential to elicit feelings of shame. The authors recount firsthand experiences of having felt shame in connection with their queer identities and the disavowal this provoked, until such time as they met serendipitously as researchers with related interests and began sharing memories of being queer in a cis-heteronormative society. Two stories, illustrated in comic form and told in first-person narrative, are centrepieces for analysis in which the authors write against themselves, their past assumptions, and interpretations. Applying insights from queer and feminist decolonial theory, and from arts pedagogy, this autotheoretical analysis demonstrates that, despite the injurious nature of shame, revisiting and recodifying its roots can help one avow queer reality and come to terms with feelings of inadequacy induced by the politics of purity infecting many fledgling efforts at self-expression.
A Poetry Pedagogy for Teachers
Authors: Loch Sarah
Published: August 2023

This is a review of A Poetry Pedagogy for Teachers: Reorienting Classroom Literacy Practices by Maya Pindyck and Ruth Vinz, with Diana Liu and Ashlynn Wittchow. The authors, U.S-based poets, educators, and arts-academics, share a crafted master class in creative thinking and poetic confidence building for teachers. They employ a strongly collaborative stance, and take readers with them on a poststructural journey by weaving together a collection of poems, scholarly literature, and resources which aim to provoke their teacher-readers to write. Readers should ready themselves with pen and paper, notebook, or computer as the many ”Invitations” (writing exercises which appear at the end of each chapter and in a section of their own towards the end) will have readers sliding into poetry and seeing it in the most unexpected places.
A Chat with Patricia Leavy on “RE/INVENTION: METHODS OF SOCIAL FICTION” BY PATRICIA LEAVY (2023)
Authors: Flemming Christina
Published: August 2023

Within this conversation, Patricia Leavy discusses her new book Re/Invention: Methods of Social Fiction. As a leading artful scholar, Leavy shines a light on the slippage between fiction and nonfiction, and the long history of merging scholarship with the literary arts. Within the paradigm of arts-based research, Leavy views social fiction as a method. She speaks about how crafting academic fiction allows for research to become both an act of discovery and a pathway toward personal healing. Christina Flemming is delighted to hear more about Leavy’s daily writing practice, her thoughts on writing as rewriting, and the metaphorical blender that is required to take one’s lived experiences and transform them into academic fiction. You can learn more about Re/Invention: Methods of Social Fiction via the Guilford Press website. To read more about Patricia Leavy, visit her website:  https://patricialeavy.com/