bluuebunny/crossref_metadata_2025 huggingface dataset:
ТРАНСПАРЕНТНІСТЬ - БАЗОВИЙ ПРИНЦИП СУСПІЛЬНО-ЦЕРКОВНИХ ВІДНОСИН
Authors: Цихуляк Іван
Published: March 2024

Стаття присвячена висвітленню ролі місії Католицької Церкви в контексті національних соціально-релігійних процесів. Суспільна увага до життя церкви піднесла її на п'єдестал найбільш значущих і впливових інституцій світу. Спектр інтересів церкви, є предметом її життєдіяльності, і водночас соціальним нервом, що підживлює інтерес у соціумі. Незважаючи на те що поняття консерватизму та лібералізму в науковому середовищі з'явились у кінці XIX століття, дискусії щодо традиційності та модернізації в церкві провадились ще ранньохристиянськими полемістами.
ОРГАНІЗАЦІЯ ДОСЛІДНИЦЬКОЇ ДІЯЛЬНОСТІ УЧНІВ З ФІЗИКИ ЗАСОБАМИ ВІДЕОАНАЛІЗУ НА ПРИКЛАДІ ПРОГРАМИ TRACKER
Authors: Сипчук Єгор , Топольник Яна
Published: March 2024

У статті розглядається важливість використання відеоаналізу під час організації дослідницької діяльності учнів з фізики. Цей засіб дозволяє учням активно та детально вивчати різні аспекти руху тіл, вимірювати фізичні величини, аналізувати закони збереження, досліджувати коливання та багато іншого. У роботі наведено основні переваги використання відеоаналізу. Особливу увагу зосереджено на програмному забезпеченні Tracker, що надає можливість візуалізувати та аналізувати рух об'єктів на відео. Використання цієї програми дозволяє здійснювати дослідження, що в реальному житті можуть бути складними або навіть неможливими. У статті зазначені основні можливості та функції Tracker та основні переваги даного засобу під час вивчення фізики. Використання програмного забезпечення  Tracker в навчальному процесі допомагає розвивати креативне мислення учнів, покращує їхні аналітичні уміння та навички застосування теоретичних знань у практичних завданнях. Такий підхід сприяє покращенню якості фізичної освіти та формуванню високого рівня дослідницької компетентності серед учнів. Застосунок Tracker є перспективним напрямом у впровадженні сучасних технологій у навчальний процес, що допомагає створювати стимулююче середовище для вивчення фізики та розвитку практичних навичок.
ПАТОГЕНЕТИЧНІ МЕХАНІЗМИ ПОРУШЕННЯ СНУ ВНАСЛІДОК СТРЕСОГЕННОСТІ COVID-19
Authors: Подпалова Ольга , Куровська Валентина
Published: March 2024

COVID-19 все ще залишається однією з найважливіших проблем сучасної медицини. Наслідки цього захворювання ще не були повністю подолані, а вже було відомо, що вірус має тропність до нервової системи. Багато досліджень свідчать також і про те, що стрес погіршує протікання COVID-19.

Коронавірус може викликати психологічні проблеми, навіть після одужання, що підтверджено результатами багатьох досліджень. Дистрес та депресія можуть призвести до послаблення імунітету і ускладнення перебігу різних хвороб, включаючи інфекційні.

Серед розладів психічної сфери, спостерігається тривога, депресія, страх, апатія та зміни настрою. Тому, ще з початком пандемії COVID-19 виявилося, що не лише фізичне, але й психічне здоров'я людей страждає. Однією з найпоширеніших проблем, пов'язаних з пандемією, є розлади сну. Сон є ключовим фактором для забезпечення ефективної роботи імунної системи. Під час сну організм активно виробляє  цитокіни, такі як інтерлейкіни та інтерферон, які грають важливу роль у боротьбі з інфекціями та підтримці імунітету. Підвищений через стрес рівень гормонів наднирникової вісі може значно вплинути на якість та тривалість сну, ускладнити процеси засинання та порушити функціонування структур, відповідальних за сон.

При недостатньому чи порушеному сні зменшується відповідь на вакцини, оскільки знижується кількість інтерлейкінів та інших важливих медіаторів. Підвищується ризик інших інфекцій, оскільки знижується імунітет та загальна стійкість організму. Терапія сну, також відома як когнітивно-поведінкова терапія інсомнії (КПТ-І), є ефективним підходом до управління проблемами зі сном та покращення якості сну. Цей вид терапії фокусується на розвитку здорових звичок та навчанні пацієнта ефективним стратегіям для поліпшення якості та тривалості сну.
« СОЦІАЛЬНЕ ЗЦІЛЕННЯ СПІЛЬНОТОЮ » В ПОДОЛАННІ КОЛЕКТИВНОЇ ТРАВМИ: ТЕОРЕТИЧНЕ УЗАГАЛЬНЕННЯ
Authors: Фанагей Ростислав
Published: March 2024

Колективна травма, пов’язана з масовими насильницькими проявами чи іншими варіантами криз та катаклізмів, є соціо-культурним явищем – порушенням цілісності одночасно і ментального стану множини індивідів, і соціальної взаємодії – на локальному й конкретному рівні спільнот та на суспільному загалом. Системним рішення у відповідь на таку комплексну проблему є «соціальне зцілення спільнотою». Завдяки налагодженню міжособистісної взаємодії на рівні спільноти, а отже відновленню чи формуванню ціннісного колективного стосунку, ця теоретико-практична настанова дозволяє впливати одночасно і на соціальну підтримку індивідуального зцілення, і на загальносоціальну нормалізацію, зокрема на підвищення ефективності громадянського суспільства.
МІСТОБУДУВАННЯ: ПОГЛЯД У МИНУЛЕ ТА ПЕРСПЕКТИВИ МАЙБУТНЬОГО
Authors: Сурмачевський Владислав , Міхно Олексій
Published: March 2024

Запропонована на широкий загал наукова робота вміщує огляд еволюції містобудування від стародавніх часів до сучасності, а також перспективи його майбутнього розвитку. Розглядаються важливі етапи історії містобудування та їх вплив на сучасну архітектурну практику та міське середовище. Висвітлюються потенційні напрямки майбутнього розвитку міст, включаючи зростання уваги до сталого розвитку, інтеграцію новітніх технологій та підвищення якості міського життя. У висновках підкреслюється важливість поєднання минулого досвіду з інноваційними підходами для створення життєздатних та естетично привабливих міст у майбутньому.
НАЦІОНАЛЬНА ОБРАЗНІСТЬ КАМЕРНО-ІНСТРУМЕНТАЛЬНОЇ МУЗИКИ ВАЛЕНТИНА БІБІКА (ФОРТЕПІАННО-ВИКОНАВСЬКИЙ АСПЕКТ)
Authors: Куліковська Єва-Евеліна , Катрич О.
Published: March 2024

Колективні уявлення людей, їх світогляд та спільні цінності символізують поняття ментальності. Національна ментальність формує головні риси, які відображають дії, вчинки і поведінку людей певної нації. В кожному національно визначеному соціумі формується культура, яка окреслює погляди суспільства на життя, створюючи унікальний ідентифікаційний код, який віддзеркалює ментальність нації. 60-70-ті роки ХХ ст. були важливим етапом в українській музиці – періодом, коли переосмислювалось розуміння національного. Результатом цього є багатогранна творчість українських композиторів того часу, зокрема харківського композитора Валентина Савича Бібіка. Його камерно-інструментальна музика – приклад надсучасного вираження самобутніх композиторських ідей, які є парадоксальним поєднанням інтелектуально-емоційної ліричної експресії, а різносторонні прояви національного збагачують образність та глибину музики В. Бібіка. В статті розглядаються соната для фортепіано № 7 ор. 49 та соната для скрипки і фортепіано № 1 ор. 71.
CHARACTERIZATION OF VIRULENCE FACTORS OF UROPATHOGENIC ESCHERICHIA COLI AND THEIR CORRELATION WITH ANTIBIOTIC RESISTANCE PATTERN.
Authors: K Vikram , Gomatheswari S. Nithya , Jeyamurugan T. , Rajendran Sasireha
Published: March 2024

Escherichia coli (E coli) is present in the gastrointestinal tract as commensals and are associated with urinary tract infections expresses virulence
factors which help to adapt and survive in the urinary tract. To study the prevalence and characterize the virulence factors - hemolysin,
haemagglutination, biolm production, serum resistance and cell surface hydrophobicity in Escherichia coli by phenotypic methods. To study the
Antibiotic Susceptibility pattern of urinary isolates of Escherichia coli. A prospective study was conducted at Govt. Thoothukudi Medical
College,Thoothukudi, India for a period of 2 months from August – September 2018. All samples were processed and subjected for detection of
virulence factors by phenotypic methods and their antibiotic susceptibility was done using Kirby Bauer Disc diffusion method. A total of 103
Uropathogenic E coli clinical isolates were collected and processed. Prevalence of UTI was 73% in females and 27% in males. Of these isolates,
61(59%) isolates showed Hemagglutination, 42 (41%) produced hemolysin, 41 (40%) exhibited serum resistance property, 54 (52%) were biolm
positive, 59 (57 %) showed cell surface hydrophobicity. Among 61 Haemagglutination positive isolates, 40 (66%) showed the presence of Type 1
mbriae (MSHA) and 21 (34 %) of Type P mbriae (MRHA).The antibiotic susceptibility testing showed High sensitivity with Amikacin (86%)
,Piperacillin tazobactum (86%), Meropenem(85%),Nitrofurantoin(78%) and least sensitivity followed by Cotrimoxazole (46%) ,Norox(46%),
cefotaxime (43%) and ceftazidime(46%). This study highlights the ability of Escherichia coli to adapt and survive in urinary tract by expressing
virulence factors and establish urinary tract infections.
LAYERING LIVESTOCK INITIATIVES WITH NUTRITIONAL PROGRAMS: ENHANCING NUTRITIONAL OUTCOMES IN JHARKHAND, INDIA.
Authors: Dash Antaryami , Chanda Pranab Kumar , Das Sharmistha , Kumar Vishal , Kumar Sanjay , Hansda Mahadev
Published: March 2024

Malnutrition remains a pervasive challenge in Jharkhand, India, particularly among tribal populations. Factors contributing to this issue include
limited access to nutritious food, inadequate healthcare, and socioeconomic disparities. This study explores the integration of livestock
interventions with nutritional programs to enhance nutritional outcomes by improving household income and dietary diversity. A quasiexperimental design was employed, comparing households in intervention areas receiving livestock and training with control areas without such
interventions. Both groups received nutrition education and support services. The study aimed to assess the impact of livestock interventions on
dietary diversity, food security, and nutritional status among children and women. he intervention group showed signicant improvements in
dietary diversity among children and adolescents, a reduction in severe food insecurity, and a decrease in child wasting. Household income
increased notably in the intervention group, leading to enhanced expenditure on nutritious food. The treatment area saw an 11% increase in
spending on nutritious foods, compared to a 4% increase in the control area. The intervention markedly enhanced dietary diversity, mitigated
severe food insecurity, and diminished child wasting within the treatment cohort, afrming the efcacy of amalgamating livestock initiatives with
bolstered nutrition services. By addressing economic barriers and enriching household dietary diversity, livestock interventions serve as a pivotal
mechanism for nutritional improvement.
EFFECT OF THE USE OF PLATELET RICH BIOLOGICALAUGMENTS IN PREVENTION OF TUNNEL WIDENING IN ACL RECONSTRUCTION: A SYSTEMATIC REVIEW
Authors: Bhatt Priyank , P. Rathi Pranav , M Devpura Mukesh
Published: March 2024

Human knee joint is a complex hinge joint of Saddle variety. Due to the degree of freedom imparted to it, the ligaments that stabilize the knee are
subjected to constant stress. This results in increased incidence of ACL injuries particularly during sports. With the advent of Arthroscopy and
better understating of ligament injuries with the use of MRI, the ligament reconstruction procedures have increased. The tunnels prepared during
the surgery are subjected to constant biological and mechanical stress during post-operative period. The resultant widening leads to failure of graft
integration and failure of ACLreconstruction surgery. In recent times biological augments have been used to prevent this tunnel widening. Various
studies have been conducted to assess the outcomes of this augments to accelerate the graft healing.
TO STUDY PREVALENCE OF DIABETES MELLITUS AND ITS RISK FACTOR IN HIV PATIENTS
Authors: Verma Snehalata , Rana Dinesh , Gautam Sandhya , Rajappan Remesh
Published: March 2024

Diabetes mellitus complicating HIV/anti retroviral therapy is an area to be focused. An increase in glucose disorders has been observed in HIV
patients receiving HAART. Aim of the study was to nd out prevalence of diabetes mellitus and its risk factor in hiv patients. Materials And
Methods:The study will be of cross sectional prevalence study include patient with conrmed status of HIV ( ELISA) admitted in Medicine ward
and attending medicine OPD 4no. and patient attended at ARTCENTRE. Atotal of 120 HIVpatients receiving anti retroviral therapy were enrolled
in the study. Results: The prevalence of diabetes mellitus in our study population was found to be 8.33%. Statistically signicant association was
found between fasting blood sugar and ART regimen, blood pressure and ART regimen, triglyceride and ART regimen, LDL and ART regimen,
HDLand ART regimen. Conclusion: Though anti retroviral therapy has signicantly decreased the mortality and morbidity of HIV patients, it has
its own metabolic complications, diabetes mellitus being one among them.Vigilant monitoring of HIV patients on anti retroviral therapy is
imperative to detect and address potential metabolic derangements.
EFFECT OF POSTERIOR FEMORAL CONDYLAR OFFSET (PCO) ON CLINICAL RESULTS OF SINGLE-RADIUS (SR) FEMORAL DESIGN IMPLANTS/COMPONENTS IN POSTERIOR STABILIZED TOTAL KNEE ARTHROPLASTY (PS TKA)
Authors: Mahawar Deep Kunwar , Mali Vikas , Audichya Tarun
Published: March 2024

Background:Total knee arthroplasty (TKA) is gold standard treatment of choice for Osteoarthritis (OA) knee. When a sufcient posterior femoral
condylar offset (PCO) is reconstructed, a larger posterior clearance may be obtained that helps delay impingement on the posterior aspect and
maximizes range of exion (ROF). However, the potential correlation between PCO and ROF, especially after posteriorly stabilized (PS) TKA,
remains controversial. This study was carried out with the objective to study the effect of PCO on clinical results on single-radius (SR) femoral
design components in PS TKA. Material and methods: This hospital based prospective observational study was conducted at Department of
Orthopedic, Santokba Durlabhji Memorial Hospital, Jaipur, Rajasthan. Between the duration of 1 January 2018 to 31 December 2018 with 6
months follow up. 50 consecutive patients were operated the with Single radius femoral design implant (SR) - Stryker Scorpio NRG PS design by a
single surgeon. Measurement of posterior condylar offset, exion (weight bearing and non-weight bearing) and knee society scoring (KSS) system
were taken preoperative and post operatively 6 months. Appropriate statistical tests were used and results were interpreted. Result: The mean age
was found 64.36 ± 7.63 years. Mostly cases (44%) were in the age group 50-60 years. Female predominance (70%) was observed. The preoperative PCO was 27.66 ± 3.20 mm and the Post-operative PCO was 29.42 ± 2.52 mm. The pre-operative exion was 112.70±8.09degrees. The
post-operative exion was121.60±3.97degrees. The mean pre-operative weight bearing exion was102.70± 7.37degrees. The mean postoperative weight bearing exion was 124.50 ± 3.81degrees. Mean pre-op knee score was 55.88 ± 3.00 while mean pre-op function score was 28.40
± 10.42. Mean post-op knee score was 84.86 ± 2.07 while mean post-op function score was 82.60 ± 4.43. Mean pre-operative and post-operative
paired differences for PCO, exion non-weight wearing, exion weight bearing, KSS knee score, KSS function score were found highly
statistically signicant for all variables. Insignicant, negative and poor correlation was observed between change in PCO and other variables like
non-weight bearing exion, KSS knee score, KSS function score, and weight bearing exion (Pearson correlation values were -0.004, P value =
0.976; -0.224, P value = 0.118; -0.036, P value = 0.805 and -0.057, P value = 0.694 respectively. Conclusion: There was signicant increase in
PCO, exion (both weight bearing and non-weight bearing), KSS knee score and function scores.
CLINICAL STUDY OF VERSATILE FLAPS FOR RECONSTRUCTION OF 100 POST BITE RESECTION DEFECTS: PROCLIVITY TOWARDS PMMC FLAP
Authors: Agrawal Palak , Chatterjee Dipmalya , Rai Rashmi , Sharma Jayesh , KN Harsha
Published: March 2024

Introduction: In India head and neck cancer patients usually present in the advanced stage, requiring extensive resections with complicated
reconstructions. The goal of reconstructive surgery is to provide functional ability, restoration of form and aesthetics. Various reconstructive
techniques are local aps, regional aps and free vascularised aps; each with its inherent advantages and shortcomings. Although microvascular
technique is the standard of care, but its use is limited by availability of expertise and resources in developing world. The common alternative in
these cases is the use of the pectoralis major myocutaneous ap (PMMC). Our article highlights the experiences and outcomes associated with
PMMC ap and its availability in resource constrained facility. Methods: A retrospective analysis of 100 patients was conducted; diagnosed with
oral squamous cell carcinoma and underwent complex resection from 2018 to 2021 in Department of Surgical oncology, Balco medical centre,
Naya Raipur. A total of 58 patients underwent reconstruction with PMMC ap, rest with free microvascular aps. All the patients were followed up
for an average period of 1 year leading to the assessment and outcomes of PMMC ap. Results: A total of 100 patients were reviewed; of these, 83
(84.69%) were male, with median age of 36.14 (31-40 years) and rest were female (16.31%) with the median age of 33.33 (51-60 years). Every
tumour was located in the oral cavity. PMMC aps were used to cover both mucosal and skin defects. The overall complication rate involving
partial ap necrosis was less in PMMC aps in comparison to other reconstructive aps. The results were in favour of PMMC aps; decreased
operative time, minimal cost and causation of additional donor site morbidity. Conclusion: PMMC ap can be a reliable and versatile option for
advanced oral malignancies with an excellent reach to face, oral cavity and neck region especially in patients with poor status with any coexisting
chronic illness. It can be considered as a valid alternative to free ap for repair of bony defects, especially in patients with low socioeconomic
corridor like India.
ROLE OF HER-2 OVEREXPRESSION IN GASTROINTESTINAL TUMORS
Authors: Padghane Shrikant , Zanwar Sneha , Kulkarni Kalpana
Published: March 2024

Introduction: HER-2 is emerging as a promising target for therapy across a variety of gastrointestinal tumors. HER-2 prevalence in patients with
gastric cancer has been reported as 30%, in gastro-esophageal junction 35%, and 3% in metastatic colon cancer. Ki-67 is used as a marker of tumor
aggressiveness. A descriptive cross-sectional study was done at a tertiary health care center for 1 Methods: 8 months.70 histopathologically proven
malignant biopsies/surgically resected specimens of the gastrointestinal tract included. In 70 case Results: s studied, the stomach and esophagus
were the most common sites. Out of 28 HER-2 positive cases, 12 had a score of 3+ on IHC. There was a signicant association between HER-2 and
Ki-67 levels among the poorly differentiated tumors. Routine testing of HER-2 in gastrointestinal t Conclusion: umors is recommended for
therapeutic advantage.
Modeling the Effects of Formulary Exclusions: How Many Patients Could Be Affected by a Specific Exclusion?
Authors: Sydor Anne M. , Bergin Emily , Kay Jonathan , Stone Erik , Popovian Robert
Published: March 2024

Background: Medication formularies, initially designed to promote the use of cost-effective generic drugs, are now designed to maximize financial benefits for the pharmacy benefit management companies that negotiate purchase prices. In the second-largest pharmacy benefit management formulary that is publicly available, 55% of mandated substitutions are not for generic or biosimilar versions of the same active ingredient and/or formulation and may not be medically or financially beneficial to patients.

Methods: We modeled the effect of excluding novel agents for atrial fibrillation/venous thromboembolism, migraine prevention, and psoriasis, which all would require substitution with a different active ingredient. Using population data, market share of the 2 largest US formularies, and 2021 prescription data, we calculated how many people could be affected by such exclusions. Using data from the published literature, we calculated how many of those individuals are likely to discontinue treatment and/or have adverse events due to a formulary exclusion.

Results: The number of people likely to have adverse events due to the exclusion could be as high as 1 million for atrial fibrillation/venous thromboembolism, 900 000 for migraine prevention, and 500 000 for psoriasis. The numbers likely to discontinue treatment for their condition are as high as 924 000 for atrial fibrillation/venous thromboembolism, 646 000 for migraine, and 138 000 for psoriasis.

Conclusion: Substitution with a nonequivalent treatment is common in formularies currently in use and is not without substantial consequences for hundreds of thousands of patients. Forced medication substitution results in costly increases in morbidity and mortality and should be part of the cost-benefit analysis of any formulary exclusion.
CONHECIMENTO DE GRADUANDOS SOBRE DOAÇÃO DE MEDULA ÓSSEA
Authors: Maria Leite Marisa Silva , Rossinoli Bruno Alexandre , De Souza Brigido Denis , Alves Correia Sílvia Manfrin , Terenciani Campoy Laura , Lombardi Fabio Renato
Published: March 2024

Objetivo: caracterizar o conhecimento dos graduandos de uma instituição de ensino superior acerca do processo de doação de medula óssea. Método:  Trata-se de um estudo descritivo com abordagem quantitativa. Foram entrevistados 266 graduandos, de ambos os sexos, entre 17 e 21 anos de idade. Foi utilizado um questionário estruturado, contendo perguntas sobre o conhecimento a respeito do processo de doação de medula óssea. Resultados: A maioria dos participantes não conhece o processo de cadastro e doação de medula óssea, tendo como a falta de informação a principal causa para a desinformação a respeito do tema abordado consequentemente resultando em pouca demanda para que mais pessoas sejam cadastradas no REDOME. Conclusão: os estudantes do ensino superior desconhecem os processos que envolvem desde ao cadastro até a doação de medula óssea, devido à desinformação e pouca divulgação sobre a temática.

Palavras-chaves:  Transplante de Medula Óssea; Conhecimento; Enfermagem.
ACESSO A REDE DE ATENÇÃO A SAÚDE EM TEMPOS DE COVID-19 POR HOMENS COM DIABETES
Authors: Dos Santos Lima Iane Abigail , Do Nascimento Damasceno Lucicleia de Lima , Candido Virnna de Melo , da Silva Costa Isabela Cristina , Moura Barroso Diogenes Lea Maria , Teixeira Queiroz Danielle
Published: March 2024

Objetivo: Estabelecer como ocorreu o acesso ao serviço de saúde dos homens com diabetes durante a pandemia SARS-CoV-2, bem como identificar seu perfil sociodemográficos. Método: O estudo se trata de uma metodologia do tipo descritiva, exploratória com abordagem quantitativa. A pesquisa foi realizada na unidade de atenção primária à saúde pertencente à Regional VI. Participaram da pesquisa homens, selecionados de acordo com os critérios pré estabelecidos. Resultados: A faixa etária da população observada varia entre trinta e setenta anos de idade, sendo que a maioria dos pacientes (46,7%) possui entre 50 e 60 anos de idade. Cerca de 66,7% dos pacientes apresentam fatores de risco. Conclusão: As condições de oferta de serviços de saúde destinados aos pacientes do sexo masculino atendidos na atenção básica foram mantidas durante a pandemia, entretanto a adaptação de acompanhamento dos pacientes à distância foi insuficiente.
DESAFIOS DO ENSINAR
Authors: Flausino de Oliveira Felipe , Carmelita Portela Moreira Laélia
Published: March 2024

A prática docente é um processo que se constrói no tempo e se estrutura em vivências e formações pertinentes ao ensino e à aprendizagem. Objetiva-se neste estudo analisar os desafios do processo de ensino a partir das experiências relatadas por docentes veteranos (que possuem mais de 7 anos de profissão) em uma instituição de ensino superior do Sul de Minas. A metodologia utilizada abarcou a aplicação de uma entrevista semiestruturada e a partir das respostas obtidas aplicou o software IRaMuTeQ que designou 3 classes de análise sobre as quais se contribuíram a técnica de análise de conteúdo. Os resultados demonstraram a importância da questão formativa profissional, nem sempre apenas na área pedagógica, os desafios de ensino para as gerações atuais, bem como o uso de ferramentas tecnológicas e de metodologias ativas de aprendizagem no cotidiano docente. Soma-se a isso, que o tempo ajudou aos entrevistados um maior amadurecimento e melhor relacionamento entre teoria e prática em suas áreas.
Boron nutrition improves peanuts yield and seed quality in a low B sandy soil
Authors: Cordeiro Carlos Felipe dos Santos , Galdi Leonardo Vesco , Silva Gustavo Ricardo Aguiar , Custodio Ceci Castilho , Echer Fábio Rafael
Published: March 2024

Peanuts are mainly grown in sandy soils with low boron content, which may limit the crop yield, especially runner-type cultivars that have high-yields. Boron deficiency causes hollow heart in peanut seeds, reducing yield and seed quality, but the best strategy to supply boron to peanut is still not known. This study aimed to evaluate peanuts nutrition, yield, and seed quality as a function of boron rate, source, and application form. The study was conducted for two years in sandy soils with low boron in southeastern Brazil. Treatments included application of boron via soil: control (boron unfertilized), boric acid at 1.5 kg ha
-1
of B, Ulexite (1.5 and 3.0 kg ha
-1
of B), and sodium tetraborate (1.5 and 3.0 kg ha
-1
of B) combined with foliar fertilization (sub-plots): 0, 400, 800 and 1200 g ha
-1
of B (boric acid) with four replicates. Boron fertilization via soil and foliar increased peanuts yield by 20 % (1100 kg ha
-1
) and 14 % (700 kg ha
-1
) - the average of the two crops, respectively. Combined use of soil and foliar fertilizer was justified only in years with water deficit and when the rate applied via soil was low (<3.0 kg ha
-1
). Boron application via soil or application of 400 g ha
-1
of B via foliar fertilization increased seed germination rate by 10 to 13 %. Boron fertilization increased the percentage of normal seedlings, seedling weight, and length and reduced the germination time. Foliar and soil boron applications efficiently improved peanut seed nutrition, yield, and quality. However, soil application performed better, showing a higher percentage of yield increase.
Pancasila sebagai Way Of Life dan implementasinya dalam pembangunan karakter bangsa
Authors: M. Bagus Prayogi
Published: March 2024

Tujuan pembuatan dari artikel ini adalah untuk memberikan gambaran tentang pentingnya Pancasila sebagai pandangan hidup berbangsa dan bernegara, terutama tentang pembangunan karakter bangsa apakah sudah terlaksanakan dengan baik atau belum. Metode yang digunakan pada artikel ini adalah metode literatur review yaitu suatu metode pengumpulan data berupa karya tulis yang dapat dijadikan sebagai bahan referensi atau rujukan dalam pembuatan artikel ini. Hasil penelitian ini adalah bahwa pada era ini telah terjadi krisis jati diri, karakteristik bangsa Indonesia. Nilai nilai Pancasila yang mulai melemah dan terasa asing ditelan perkembangan zaman. hal tersebut dapat kita lihat dari besarnya ketimpangan ekonomi, kebijakan dan kemasyarakatan, ketidak adilan, kriminalitas, korupsi, pelanggaran HAM dll. Dapat disimpulkan bahwa pembentukan karakteristik bangsa telah dilupayakan menggunakan banyak cara, tapi sampai saat ini pun belum terlaksana secara maksimal.
Implementasi Implementasi Peraturan Desa Untuk Meningkatkan Civic Engagement Masyarakat
Authors: Fandi Fandi Zahri , Erwin  , Purnama Shilmy , Bistari  , Sastra Atmaja Thomy
Published: March 2024

Peraturan desa merupakan produk hukum memiliki kedudukan sendiri dalam kehidupan masyarakat desa sebagai pedoman dalam penyelenggaraan pemerintah desa. Kurang fasilitas pembangunan yang layak lingkungan desa sebagai penunjang masyarakat sehingga mendorong terciptanya peraturan desa. Tujuan penelitian untuk mengetahui gambaran impelemtasi peraturan desa terhadap peningkatan civic engagement masyarakat, Metode penelitian yang digunakan adalah pendekatan kualitatif melalui observasi, wawancara mendalam kepada masyarakat, lembaga masyarakat dan pemerintah desa dan dokumentasi. Hasil penelitian menujukan bahwa implementasi peraturan desa terhadap civic engagement masyarakat bentuk pelaksanaan implementasi peraturan desa dilakukan dengan pembangunan sarana dan prasarana berupa jalan dan banjar, jembatan, irigasi dan pintu air, serta pemasangan lampu penerangan jalan. Gambaran pelaksanaan masyarakat mampu berkontribusi, membangun pengorganisasian, beraksi atau bertindak, memotivasi dan bertanggungjawab dalam implementasi peraturan desa. Perlunya peningkatan komunikasi, edukasi, dan pengunaan teknologi untuk membantu meningkatkan keterlibatan masyarakat. Dengan demikian, penelitian ini diharapkan mampu memberikan kontribusi pada pemahaman lebih lanjut tentang implementasi peraturan desa untuk meningkatkan civic engagement masyarakat.
TranSa(n)ktionen, Regulierung, Krypto- & Klepto: Neue und alte Phänomene auf dem Kapitalmarkt - Kapitalmarkt – Recht und Transaktionen XVIII – Tagungsband 2022
Authors: Ginter Petra , Hertner Jonas , Leisinger Benjamin , Paumgartner-Schori Rebecca , Portmann Matthias , Remund Cédric , Roesler Lukas , Schneitter Michael , Spoerlé Philip , Weber Annette
Published: March 2024

Entdecken Sie in diesem Tagungsband einen tiefen Einblick in die dynamischen Entwicklungen und Herausforderungen der globalen Finanzmärkte, präsentiert im Rahmen der 18. EIZ-Tagung „Kapitalmarkt – Recht und Transaktionen“. Die geldpolitische Schwemme, ausgelöst durch die Pandemie, hat den Kapitalmarkt nachhaltig beeinflusst und zu einer Neubewertung etablierter Paradigmen geführt. Inmitten globaler politischer Unruhen und dem Ukrainekonflikt zeichnen sich transformative Veränderungen ab. Von der Renaissance überholter Finanzinstrumente bis zu innovativen Blockchain-Produkten reflektieren die Expertenbeiträge die Vielfalt des Wandels. Ein unverzichtbares Werkzeug für alle, die die Zukunft der Kapitalmärkte verstehen wollen.
Neurodevelopmental disorders and the role of PSD-95: Understanding pathways and pharmacological interventions
Authors: Medina Gerardo , MacKenzie Alex E.
Published: March 2024

Neurodevelopmental disorders (NDDs) are often linked to disruption in brain development and present challenges for affected individuals in achieving their cognitive, emotional, and motor developmental milestones. NDDs encompass a spectrum of conditions, including autism spectrum disorder (ASD), schizophrenia (SCZ), attention-deficit hyperactivity disorder (ADHD), and epilepsy. The unequivocal diagnosis of an NDD is often challenging due to overlapping signs and symptoms across different conditions. Synaptic plasticity, the activity-driven modification of synaptic strength and efficacy, plays a crucial role in brain network formation and organization and is frequently altered in NDDs. Here, we explore the multifaceted roles of postsynaptic density-95 kDa (PSD-95) in NDDs. Psd-95 is a scaffolding protein belonging to the membrane-associated guanylate kinases (MAGUKs) family, located at the core of synapses, and is central to synaptic plasticity. Dysregulation of PSD-95 is linked to various neuropsychiatric disorders. In SCZ, decreased PSD-95 expression affects synaptic plasticity, thereby impacting learning and memory. Genes associated with ASD interact with PSD-95, and its removal in mice leads to ASD-like behavioral abnormalities. Furthermore, PSD-95 is implicated in ADHD, where its modulation influences neurotransmission. Medications used in NDD treatment, such as antipsychotic drugs and selective serotonin reuptake inhibitors (SSRIs), can alter PSD-95 levels, potentially influencing synapse formation. Alpha-2 adrenergic agonists might enhance synaptic integrity by impacting PSD-95. Alternative pharmacotherapies such as memantine, allopurinol, and ketamine, all influencing PSD-95 to a certain extent, hold promise in managing NDDs. Understanding the role of PSD-95 in these disorders can deepen our biological comprehension and pave the way for targeted therapies. Specifically, exploring how PSD-95 affects synaptic plasticity and dendritic spine development could uncover opportunities for repurposing drugs to treat NDDs associated with mutations in the DLG4 gene encoding PSD-95.
Signatures of neurological adverse events after vaccination
Authors: Ricke Darrell O. , Rose Jessica
Published: March 2024

There have been reports associated with the development of neurological adverse events (AEs) post-vaccination. Here, we retrospectively examine the Vaccine Adverse Events Reporting System (VAERS) database for neurological AEs reported following vaccination. Since VAERS is a passive reporting system, to minimize reporting bias and to reduce background events, this retrospective study examines both age-stratified AE reports made with onset within 24 h of immunization, and age-stratified AE reports regardless of timeframe from immunization. Immediate temporal onset data patterns for febrile convulsion, seizure, and syncope AEs were observed for multiple vaccines. For age-stratified AEs in infants up to 3 years of age, the following patterns of high association were observed: (i) Aphasia, autism spectrum disorder, and speech disorder were found to be highly associated with the measles, mumps, and rubella and hepatitis B (HepB) vaccines; (ii) febrile convulsion and syncope were found to be highly associated with the meningococcal group B vaccine; and (iii) seizures were found to be highly associated with diphtheria and tetanus toxoids and whole-cell pertussis (DTP) vaccines.
From digital to quantum epidemiology: The Quantum Data Lake concept for big data related to viral infectious diseases
Authors: Kolesnichenko Olga , Nakonechniy Igor , Kolesnichenko Yuriy
Published: March 2024

The development of quantum epidemiology represents the next anticipated phase in epidemiology transformation, driven by the emergence of new quantum technologies. Epidemiology is currently transitioning into the digital era and undergoing a paradigm shift from a data-driven to a value-driven strategy. Epidemiology data are characterized by uncertainty, multidimensionality, and disconnection, thereby correlating with the preferential quantum approach for data exposition, value creation, and modeling. Examples of such complex epidemiology data include the data on DNA viruses with associated symptoms and diseases. The Quantum Data Lake concept is proposed and consists of several layers and quantum tools, including Robson semantic triples, Quantum Universal Exchange Language, Hyperbolic Dirac Net, “quantum ribosome” structure, quantum random access memory, teleportation, Quantum Query Language, non-Hermitian gates, and tensor networks (e.g., matrix product state, projected entangled pair state, and multiscale entanglement renormalization ansatz [MERA]), alongside PT-symmetry properties. PT-symmetry can serve as an intuitive modeling tool, and PT-symmetry breaking can detect the hidden shift in the information that is permanently updated in the Data Lake. The computational output is presented as PT-symmetry gain/loss equilibrium breaking in the form of a complex number, i.e., two possible variants of epidemic modeling. For MERA, non-Hermiticity with spontaneous PT-symmetry breaking can theoretically appear as a violation of the entanglement monotonicity and local entanglement gain, leading to a non-reversible character of the coarse-graining transformation. The duality of PT-symmetry equilibrium breaking can be compared to, for example, the estimation of the best and worst scenarios simultaneously, or the gain of entanglement can display a significant correlation between some studied parameters embedded into the data. The fundamental difference between digital and quantum epidemiology is the implementation of quantum logic and reliance on a quantum theory.
Cyanine-induced apoptosis for cancer therapy
Authors: Cui Kunli , Miao Chenguang , Feng Dong , Dong Jiaheng , Zhou Yaqi , Ji Xinying , Zhang Lei
Published: March 2024

Apoptosis is a programmed cell death characterized by cell rounding, chromatin condensation and clumping, cytoplasmic collapse, and the formation of apoptotic bodies. Recently, increasing scientific research has disclosed the close relationship between apoptosis and cyanine. Cyanine, due to its excellent fluorescent characteristics, is used in constructing vital fluorescent cores for fluorescent probes. It has been extensively utilized in targeted labeling for growing cells and tumor phototherapy. Cyanine-derived compounds have provided new approaches for treating different cancers by inducing tumor cell apoptosis. This review introduces the molecular mechanism of apoptosis, essential apoptosis-related proteins, and the pathways related to tumor cell apoptosis. Furthermore, it systematically discusses the function of cyanine in cancer therapy by inducing apoptosis. A deeper understanding of cyanine-induced apoptosis may offer new options for cancer treatment and new strategies for developing and utilizing cyanine.
Ineffective voluntary motor improvement through non-invasive BCI-FES with static magnetic field in complete spinal cord injury: A pilot study
Authors: Gomes Sartori Larissa , Burgo de Souza Roger , Prado Campos Daniel , Broniera Júnior Paulo , Jair Alves Mendes Junior José , Krueger Eddy
Published: March 2024

In response to the challenge of spinal cord injury (SCI) rehabilitation, this study aimed to investigate the effect of applying a non-invasive interface of surface neuroelectrical signals and functional electrical stimulation (sNES-sFES) with a static magnetic field on the motor outcome of the quadriceps femoris muscle in an individual with a complete SCI. The participant, who had a complete SCI in the chronic stage, was evaluated before (pre) and after nine (post) interventions using surface electromyography (sEMG). In addition, spasticity (modified Ashworth scale [MAS]) was observed in all sessions. Moreover, the user learning curve process (classifier percentage and correct success of the sFES hits) was evaluated. In general, we observed: (i) No voluntary muscle contraction (pre- and post-root mean square of sEMG = 0%) improvement; (ii) spasticity decrease (average one point in MAS); (iii) gradual improvement in the user learning effect on the interface, reaching 84% in classifier accuracy and a maximum percentage of correct sFES activation of 53%. In conclusion, no improvement in voluntary muscular contraction was observed within 9 weeks of the intervention (1 session/day; 1 h/week). However, our study demonstrates the safety and feasibility of our methodology for future research involving continuous physical rehabilitation training and the implementation of assistive technology.
Worker Health in Brazil
Authors: Azevedo Marcia Carvalho de , McPhee Deborah
Published: March 2024

Occupational health and safety (OH&S) is related to the health, safety, and welfare issues in the workplace.  It is guided by laws, standards, and programs aimed at making the workplace safer for workers, along with co-workers, family members, customers, and other stakeholders. Improvement in a company's occupational health and safety standards has the potential to improve the overall business environment and contribute to a better quality of work life. Brazil has historically reported high numbers of work accidents, which may have serious consequences to workers, resulting in permanent disability or even death. The country has also been developing some very successful policies related to worker health during the last years. The objectives of this paper were to analyze the evolution of statistics of work accidents in Brazil and the impact of some demographic and work variables in these numbers. Although there is a high incidence of workplace accidents in Brazil, there has been a reduction in the incidence of accidents, death, and accident-driven retirement. Despite the identified progress the situation is still extremely worrying. Responsibility for the construction, promotion and maintenance of a safe work environment should be shared by everybody - organizations, workers, unions, health system, among others, as being safe at work is a central aspect for quality of life.
Empreendedorismo e Desenvolvimento Local
Authors: Araújo Paulo Henrique Marcon , Oliveira Edi Carlos de
Published: March 2024

Atualmente o mundo vem passando por diversas transformações que podem fomentar práticas empreendedoras que estimulem o desenvolvimento local. Esse artigo tem por objetivo analisar os impactos proporcionados pelas ações da Sala do Empreendedor do município de Loanda – PR aos empreendedores, para fomentar o desenvolvimento local. A Sala do Empreendedor é busca incentivar os empreendedores a manter a empresa com as obrigações em dia e, consequentemente, o desenvolvimento local no município. Trata-se de uma pesquisa qualitativa, descritiva e exploratória, caracterizada como estudo de caso, com dados provenientes de entrevistas semiestruturas com dez empreendedores locais. Os dados foram interpretados através da técnica de análise de conteúdo e os resultados apontam que nos últimos anos a sala do empreendedor tem contribuído com o empreendedorismo local, dando suporte às pessoas que desejam empreender e que não possuem os conhecimentos necessários, o que tem proporcionado empreendimentos mais sólidos com capacidade de impulsionar o desenvolvimento local.
Empreendedorismo e Inovação
Authors: Albano Cláudio Sonaglio , Vasconcelos Érica de Almeida
Published: March 2024

Empreendedorismo e Inovação são dois temas recorrentes na atualidade, em especial visando promover desenvolvimento econômico e social. Neste sentido a integração de diversos segmentos da sociedade é extremamente importante, em especial de instituições de ensino e pesquisa. Assim, este trabalho tem como objetivo descrever o panorama dos projetos desenvolvidos com foco nos temas inovação e/ou empreendedorismo em uma universidade federal. Para o desenvolvimento do trabalho foi utilizada a ótica conceitual da bilbliometria, a partir dos projetos de ensino, pesquisa e/ou extensão registrados no sistema da instituição. Como principais resultados, pode-se destacar: a pouca oferta de projetos relacionados aos temas em um campus que oferta cursos que historicamente estão mais alinhados aos temas; forte oferta de projetos em um Campus com atividades relacionadas à área da saúde; a oferta dos projetos ocorreu em boa parte na área de extensão, esta área pressupõe relações entre a universidade e a sociedade, fato este que vai ao encontro dos objetivos da implementação da universidade na região; e finalmente a oferta de projetos em Campus com cursos da área das Ciências Sociais Aplicadas.
Abordagem Conceitual Sobre Inovação a Partir do Manual de Oslo
Authors: Macohon Klosowski Ana Lea , Fuck Marcos Paulo
Published: March 2024

Artigo tem como objetivo analisar a evolução dos conceitos de inovação ao longo das quatro edições do Manual de Oslo (MO), que, em grande medida, sintetiza debates a respeito do tema. Utilizou-se da revisão narrativa para descrever e discutir o desenvolvimento do assunto sob ponto de vista teórico e contextual. Com abordagem descritiva e qualitativa, o estudo constituiu-se da análise da literatura publicada em livros, manuais e artigos de periódicos e de eventos científicos. Os resultados mostram que ao longo das quatro edições as definições foram estendidas e novas conceituações foram atribuídas. O termo "inovação" passou a ser usado em diferentes contextos, como "atividades de inovação", referindo-se ao processo e "inovação", referindo-se a resultados. As definições levam a orientações sobre como as empresas podem ser caracterizadas, reconhece a possibilidade de ocorrerem inovações em outros tipos de organização, não ficando restritas às inovações tecnológicas e organizacionais, podendo ser institucionais e sociais.
Evolução da Produção Científica em Inovações e Adoção de Tecnologias na Cadeia Produtiva de Leite
Authors: Juliani da Silva Portal Mariana , Andreatta Tanice , Milagre Machava Constantino , De Mattos Fagundes Paloma , Marisa Spanevello Rosani , Zardin Patias Tiago
Published: March 2024

A inovação tecnológica constitui-se como alternativa para melhorar a flexibilidade, adaptabilidade e produtividade nas cadeias agroalimentares, visando principalmente reduzir custos de produção e tempo de trabalho nas fazendas. Mas a difusão e adoção de novas tecnologias nas fazendas leiteiras, mesmo em países desenvolvidos, ainda é limitada. Fatores como a falta de conhecimento, custo-benefício percebidos, idade, pouca familiaridade às tecnologias, crenças e atitudes dos produtores são fatores que dificultam as inovações e/ou adoção de tecnologias de maneira efetiva. Diante da importância da inovação para a cadeia produtiva do leite, este estudo objetiva analisar a produção científica mundial voltada à inovação tecnológica e adoção de tecnologias na cadeia produtiva do leite. Os resultados demonstram o crescimento da produção científica, principalmente nos últimos 10 anos, revelam a importância da pesquisa e extensão direcionadas à temática da inovação como alternativa para melhorar o desempenho e a competividade da cadeia produtiva do leite.
Śrīkhṛṣṭa-saṃgītā : William Hodge Mill’s Sanskrit Christian Purāṇa
Authors: - Soumyajit Sen , - Pampa De
Published: March 2024

In the wake of Christian missionaries’ arrival in India, a profound engagement with Sanskrit ensued, resulting in the emergence of ‘Church Sanskrit’ Literature. This genre not only witnessed translations of sacred texts like the Bible but also spawned original compositions centered on Jesus Christ, serving as a vehicle for propagating the Christian faith among the Sanskrit-knowing intelligentsia. Notably, figures like William Hodge Mill played a pivotal role, crafting monumental works such as the Śrīkhṛṣṭa-saṃgītā, which garnered acclaim for its literary and scholarly merits, transcending even revered indologists of the time. His mastery of Sanskrit reached such extraordinary heights that Kamlākānta Vidyālaṅkār, a prominent Bengali scholar, bestowed upon him unprecedented praise, elevating him above esteemed figures like William Jones, William Carey, and James Colebrooke. Vidyālaṅkār’s proclamation likened him to the rebirth of Kālidāsa, the revered ancient poet, affirming the unparalleled excellence of his Sanskrit scholarship. Meanwhile, the Śrīkhṛṣṭa-saṃgītā, while serving as a historical testament to the life of Jesus Christ, transcends mere documentation. Rooted in Western interpretations of the Gospels, it stands as a literary masterpiece, blending historical narrative with artistic expression in a manner reminiscent of the belletristic tradition.
The research paper discusses the unique attributes of the Śrīkhṛṣṭa-saṃgītā through the lens of Sanskrit Poetics, exploring its historical narrative while elucidating its impact on nineteenth-century Indian society. Through meticulous analysis, it seeks to unravel the interplay between literary artistry and historical accuracy in this seminal work, shedding light on the cultural and intellectual landscape shaped by ‘Church Sanskrit’ literature. By synthesizing scholarly inquiry with linguistic and literary expertise, this paper aims to contribute to a deeper understanding of the profound influence of Christian narratives in Sanskrit form on the socio-cultural fabric of colonial India.