bluuebunny/crossref_metadata_2025 huggingface dataset:
Antibiotic resistance of Helicobacter pylori in Nanjing, China: A cross-section study from 2018 to 2023
Authors: Wei Wenjuan , Wang Zhibing , Li Chao , Jiang Zongdan , He Bangshun , Zhang Zhenyu , Wang Shukui
Published: September 2023

Background The increasing prevalence of antibiotic resistance in cases ofHelicobacter pylori(H. pylori) infection has emerged as a significant global issue. This study investigates the resistance situations, particularly the levofloxacin resistance pattern ofH. pyloriin Nanjing, China. Methods This research screened 4277 individuals diagnosed withH. pyloriinfection between April 2018 and May 2023. The phenotype and genotype resistance were evaluated using the Kirby-Bauer disk diffusion and ARMS-PCR method. Results The most recent primary resistance rates for metronidazole, clarithromycin, levofloxacin, amoxicillin, furazolidone, and tetracycline were recorded at 77.23% (2385/3088), 37.24% (1150/3088), 27.72% (856/3088), 0.52% (16/3088), 0.19% (6/3088), and 0.06% (2/3088), respectively. For the recent five years, we observed a notable upsurge in the rate of metronidazole resistance and a slight elevation of clarithromycin and levofloxacin resistance. The documented overall resistance rates to single-drug, dual-drug, triple-drug, and quadruple-drug regimens were 34.98%, 27.99%, 25.42%, and 0.21%, respectively. The prevalence of multidrug-resistant strains escalated, rising from 37.96% in 2018 to 66.22% in 2023. Strains from patients without levofloxacin eradication history showed significantly lower phenotypic (57.10%) and genotypic (65.57%) resistance rates compared to those with a history (94.74% and 88.73%, respectively). The prevailinggyrAmutations were primarily N87K (52.35%, 345/659), accompanied by D91N (13.96%, 92/659), and closely followed by D87G (10.77%, 71/659). An observed kappa value of 0.910 signifies strong concordance between ARMS-PCR and antibiotic sensitivity testing when identifying levofloxacin resistance. ForgyrAmutations, the 91-amino acid mutants exhibit a higher likelihood of discrepancies between phenotypic and genotypic resistance than the 87-amino acid mutants. Conclusions The extent of antibiotic resistance withinH. pyloriremains substantial within the Nanjing region.Keeping track of regional information regarding antibiotic resistance inH. pyloriis crucial for customizing individual treatment approaches. If levofloxacin proves ineffective in eradicatingH. pyloriduring the initial treatment, its use in subsequent treatments is discouraged. The employment of levofloxacin resistance genotype testing can partially substitute conventional antibiotic sensitivity testing. Notably, predicting phenotypic resistance of levofloxacin through ARMS-PCR requires more attention to the mutation type ofgyrAto improve prediction accuracy.
Research on fruit and vegetable classification and recognition method based on Depth-wise Separable Convolution
Authors: Yue Zhen , Weng Jia-jie , Miao Zhuang , Sun Ying-kun
Published: September 2023

Aiming at the problem that the settlement process in agricultural trade markets and fruit and vegetable supermarkets is not intelligent enough and the difficulty of deploying heavy neural network models, the lightweight recognition method of fruit and vegetable classification model is studied. Firstly, aiming at the complex environmental problems of fruit and vegetable supermarkets and farmers' markets and the subsequent practical use, a multi-scene collection scheme was used to collect 170 kinds of fruits and vegetables and 136,000 pictures in the fruit and vegetable supermarket, and an image preprocessing scheme for weakened bagging was formulated to further enhance the data. Then, a fruit and vegetable classification recognition model based on Depth-wise separable convolution is designed, trained and tested. Its top-1 success rate has reached 96.8%, the top-5 success rate has reached 100%. Compared to Mobilenetv2-224, the amount of computation has been reduced by 70%, compared to Mobilenetv3-224, the amount of computing has also been reduced by 60%, and the recognition ability was higher than Mobilenetv2-224 and lower than Mobilenetv3-224. Finally, the problems faced by the designed fruit and vegetable classification model in the actual deployment are analyzed.
Streptococcus pneumoniae serotype distribution in Bangladeshi under-fives with community- acquired pneumonia pre-10-valent pneumococcal conjugate vaccination
Authors: Vestjens Stefan M.T. , Mens Suzan P. van , Meek Bob , Lalmahomed Tariq A. , de Jong Ben , Goswami Doli , Vlaminckx Bart J.M. , Ahmed Dilruba , de Jongh Bartelt M. , Endtz Hubert P. , Brooks W. Abdullah , Rijkers Ger T.
Published: September 2023

Background
Streptococcus pneumoniae is the most frequent causative pathogen of bacterial pneumonia in children worldwide. Bangladesh introduced the 10-valent pneumococcal conjugate vaccine (PCV10) in their national immunization program for infants in 2015. We assessed its potential coverage in under-fives with community-acquired pneumonia (CAP) in the years beforePCV10 was introduced.
Methods
A total of 1502 childhood pneumonia cases (<5 year olds living in the urban section Kamalapur, Dhaka) were enrolled between 2011 and 2013. Acute phase and late (convalescent) serum samples were collected from 1380 cases. Serotype-specific pneumococcal antibody concentrations were measured using a 25-plex immunoassay panel. Pneumococcal CAP was diagnosed based on a serotype-specific pneumococcal antibody response.
Results
S. pneumoniae was serologically identified as causative pathogen in 406/1380 (29%) cases. The five most prevalent serotypes were (in descending order) 11A, 22F, 3, 2 and 19F. Based on the percentage of pneumonia cases associated with PCV10 vaccine types, the potential PCV10 coverage was 29% (116/406).
Conclusions
In almost a third of the studied cases S. pneumoniae was identified as causative pathogen. Because of the characteristics of the immunoassay, this might well be a gross underestimation. Nevertheless, the potential PCV10-coverage was low. Given the high serotype diversity, the region might benefit greatly from a higher-coverage PCV or recombinant protein vaccine.
RETRACTED: An Efficient Cat-Boost Classifier optimized with Woodpecker Mating Algorithm to predict and diagnose Type 2 Diabetes
Authors: Arumugam Prakash , Rani R. Suneetha , Peddireddy Bhargavi , Praveena Murala
Published: September 2023

The authors have requested that this preprint be removed from Research Square.
Treatment of cervical esophageal carcinoma: systematic review and meta-analysis
Authors: Chichevatov D. A. , Seliverstova O. M. , Dmitriev S. P.
Published: September 2023

Objectives. Up to date managing a cervical esophageal carcinoma (CEC) has remained a controversial challenge. The choice of treatment is still uncertain. In the present review we attempted to assess eligibility of surgery in treatment of CEC. Material and Methods. We have enquired particular publication databases and the enquiries yielded 24 contributions matching study selection criteria such as (1) original articles published from 2000 to 2022, (2) primary tumor localization in the cervical esophagus, (3) squamous cell carcinoma, (4) available characteristics of studied groups (age, sex, T, N, M, stage), (5) detailed description of curative procedures (radiation therapy, chemotherapy, surgery), (6) information about overall survival. These publications represented two arms of 14 surgical and 17 non-surgical subgroups to analyze. Individual patient data and parameter estimates have been renewed on the basis of original Kaplan‒Meier curves plotted. Results. The analysis revealed a highly heterogeneous (I2 =83.76 %; 95 % CI, 71.40–92.16) random effects model. Including a surgical option into treatment of CEC did not affect 3-year overall survival (р=0.665); 46.4 % (95 % CI, 37.4–55.6) vs 43.7 % (95 % CI, 35.3–51.6), respectively. Possibilities of surgical and non-surgical modalities employment were discussed. Conclusion. In treatment of CEC CRT and surgery are non-inferior to each other. These modalities are evenly associated with posterior side effects and complications, which adversely affect functional outcomes and survival. The choice of a treatment mode may depend on tumor response to induction therapy. The latter demands further investigations.
Chemoradiotherapy effcacy in squamous cell rectal cancer: a propensity score matched analysis
Authors: Murzo V. V. , Gordeev S. S. , Myshlyakov V. S. , Mamedli Z. Z.
Published: September 2023

Introduction. Sporadic cases of squamous cell carcinoma of the rectum (rSCC) do not allow a comparative characterization of tumor aggressiveness and its response to chemoradiotherapy in relation to more common squamous cell entities, in particular, anal squamous cell carcinoma (aSCC). Objective: comparative evaluation of the short- and long-term results of chemoradiation therapy in patients with rSCC and aSCC. Material and Methods. In this retrospective study we included patients with nonmetastatic squamous cell carcinoma of the rectum (rSCC) and anal canal squamous cell carcinoma (aSCC) who received chemoradiotherapy and compared them in a 1:1 ratio using propensity-score matching. The dynamics of tumor response to treatment were compared by Kaplan-Meier survival analysis (OS and RFS) followed by Log-Rank verifcation, rate of complete response after 6 months. Results. A total of 15 pairs of matched patients were evaluated. Patients in both groups had reliably similar sex, age, histological grade, initial primary tumor size, differing only in tumor histological subtype. In the aSCC group, 60 % of patients had metastases to pelvic lymph nodes, while in the rSCC group metastases had 46.67 % (p=1). The median follow-up was 44 months. The 3-year OS in the aSCC group of patients was 76.9 %, and 71.4 % in the rSCC group (p=0.567). The 3-year DFS in the aSCC group was 66.7 %, and in the rSCC group 34.7 % (p=0.406). The rate of achieving complete clinical response to CRT after 6 months was 86.7 % for the aSCC group and only 46.7 % for the rSCC group (p=0.05). Organ-saving treatment was achieved in 93.3 % of aSCC patients and 73.3 % of rSCC patients (p=0.33). Conclusion. Overall and recurrence-free survival rates were not signifcantly decreased for rSCC patients relative to aSCC patients. This indicates a similar course and prognosis in the two diseases, but rSCC is characterized by a signifcantly lower rate of complete response to treatment.
Ascite-solid model of prostate cancer and its morphological characteristics
Authors: Plotnikova E. A. , Morozova N. B. , Ryabova A. V. , Trunova G. V. , Khokhlova V. A. , Loschenov V. B. , Pankratov A. A. , Kaprin A. D.
Published: September 2023

Targeted therapy and immunotherapy are considered promising novel therapies capable of increasing the effcacy of prostate cancer (PCa) treatment. The purpose of the study was to obtain and characterize TRAMP-C2 subcutaneous and ascite-solid models of prostate cancer in C57Bl/6j mice to study specifc anti-tumor activity of the candidate molecules of targeted drugs and adjust immunotherapy strategies in an evidence-based manner. Material and Methods. We used cultured TRAMP-C2 cells in subcutaneous and ascites mouse prostate cancer models. Histological and immunohistochemical methods were used to study the tumor tissues. Results. The high in vivo growth ability of TRAMP-C2 cells was demonstrated in subcutaneous and intraperitoneal inoculation of C57Bl/6j mice. These tumors are characterized by a high reproducibility and level of PSMA expression. Histological study showed that subcutaneous and carcinomatous TRAMP-C2 tumor nodules had solid structure morphologically corresponding to low differentiated neoplasm, cytomorphological analysis of smears showed that peritoneal fuid containd a large number of rounded tumor cells, macrophages and erythrocytes. Conclusion. The obtained subcutaneous and ascite-solid models of TRAMP-C2 can be useful for the development of new ways to effectively treat cancer, including targeted and immunotherapy, as well as for the experimental study of biotherapeutic effects using PSMA as a target, and photoinduced effects.
Rapidly Eroding Piñon–Juniper Woodlands in New Mexico
Authors: Hastings Brian K. , Smith Freeman M. , Jacobs Brian F.
Published: September 2023

The piñon (Pinus edulis Engelm.)–juniper [Juniperus monosperma (Engelm.) Sarg.] woodlands of Bandelier National Monument are experiencing accelerated erosion. Earlier studies suggest that causes of these rapidly eroding woodlands are related to an unprecedented rapid transition of ponderosa pine (Pinus ponderosa C. Lawson) savanna to piñon–juniper woodlands as a result of cumulative historical effects of overgrazing, fire suppression, and severe drought. To study the effectiveness of slash treatment in reducing accelerated erosion, we used sediment check dams to quantify sediment yield from twelve paired microwatersheds (300–1100 m2) within an existing paired watershed study. Six of the twelve microwatersheds were located in a 41‐ha (treatment) watershed with scattered slash treatment, whereas six microwatersheds were located in an adjacent 35‐ha untreated (control) watershed. The primary purpose of our research was to quantify the rates of sediment yield between the treated and control microwatersheds. Sediment yield was measured from 15 individual storms during the months of June–September (2000 and 2001). In response to slash treatment, mean seasonal sediment yield for 2000 equaled 2.99 Mg/ha in the control vs. 0.03 Mg/ha in the treatment and 2.07 Mg/ha in the control vs. 0.07 Mg/ha in the treatment in 2001. The practice of slash treatment demonstrates efficacy in reducing erosion in degraded piñon–juniper woodlands by encouraging herbaceous recovery. Our data show that slash treatment increases total ground cover (slash and herbaceous growth) beyond a potential erosion threshold. Restored piñon–juniper woodlands, as the result of slash treatment, provide a forest structure similar to pre‐grazing and pre‐fire suppression conditions and decrease catastrophic fire hazard.
Pulsed Redistribution of a Contaminant Following Forest Fire
Authors: Johansen Mathew P. , Hakonson Thomas E. , Whicker F. Ward , Breshears David D.
Published: September 2023

Of the natural processes that concentrate dispersed environmental contaminants, landscape fire stands out as having potential to rapidly concentrate contaminants and accelerate their redistribution. This study used rainfall simulation methods to quantify changes in concentration of a widely dispersed environmental contaminant (global fallout 137Cs) in soils and surface water runoff following a major forest fire at Los Alamos, New Mexico, USA. The 137Cs concentrations at the ground surface increased up to 40 times higher in ash deposits and three times higher for the topmost 50 mm of soil compared with pre‐fire soils. Average redistribution rates were about one order of magnitude greater for burned plots, 5.96 KBq ha−1 mm−1 rainfall, compared with unburned plots, 0.55 KBq ha−1 mm−1 rainfall. The greatest surface water transport of 137Cs, 11.6 KBq ha−1 mm−1, occurred at the plot with the greatest amount of ground cover removal (80% bare soil) following fire. Concentration increases of 137Cs occurred during surface water erosion, resulting in enrichment of 137Cs levels in sediments by factors of 1.4 to 2.9 compared with parent soils. The elevated concentrations in runoff declined rapidly with time and cumulative precipitation occurrence and approached pre‐fire levels after approximately 240 mm of rainfall. Our results provide evidence of order‐of‐magnitude concentration increases of a fallout radionuclide as a result of forest fire and rapid transport of radionuclides following fire that may have important implications for a wide range of geophysical, ecosystem, fire management, and risk‐based issues.
CAREGIVERS STRESS AND ITS PREDICTORS WHILE CARING DEMENTIA PATIENTS DURING COVID-19 PANDEMIC
Authors:   M.Sc. Nursing, National Institute of Nursing Education, Post Graduate Institute of Medical Education and Research, Chandigarh., Bala Madhu , Sharma Sunita ,   Department of Nursing, National Institute of Nursing Education, Post Graduate Institute of Medical Education and Research, Chandigarh., Sharma Renu ,   Department of Nursing, National Institute of Nursing Education, Post Graduate Institute of Medical Education and Research, Chandigarh., Mehra Aseem ,   Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh.
Published: September 2023

Background: The COVID-19 pandemic had a great impact on dementia patients as well as on their caregivers. The caregivers of such patients face great difficulties and marked level of stress in dealing with their patients during COVID-19. The roles and responsibilities of the caregivers also increased and messed up with daily routines due to sudden changes in the environmental situation because of COVID. Aim: To assess the level of stress among the caregivers of patients with dementia during COVID pandemic. Methods: A cross sectional research design in which purposive samples of 31 caregivers of patients with dementia were selected for the study. The caregivers who were stayed with the patients for at least one year and were fulfilled the eligibility criteria were participated in the study. The data was collected by using a telephonic interview on one to one basis. Perceived stress scale (PSS-10) was used to assess level of stress among the caregivers. Results: The findings of the study have shown that the majority of the caregivers of patients with dementia 90.3% had moderate stress level. Conclusion: The roles and responsibilities of caregivers of patients with dementia become challenging during COVID which affect their mental health also. The emphasis is on the stress management strategies for the caregivers and shared responsibilities of caring their patients.
REACTIVITY OF DISUBSTITUED AMMONIUM SELENIATE SALTS WITH SNME3CL. X-RAY STRUCTURE OFCY2NH2SEO4SNME3
Authors:   Laboratoire de Chimie Minerale et Analytique, Departement de Chimie,Faculte des Sciences et Techniques, Universite Cheikh Anta Diop, DAKAR, Senegal., Diouf Boucar , Diallo Waly ,   Faculte des Sciences et Techniques de lEducation et la Formation, Universite Cheikh Anta Diop, DAKAR, Senegal., Sembene Boye Mouhamadou ,   Laboratoire de Chimie Minerale et Analytique, Departement de Chimie,Faculte des Sciences et Techniques, Universite Cheikh Anta Diop, DAKAR, Senegal., Ndoye Daouda ,   Laboratoire de Chimie Minerale et Analytique, Departement de Chimie,Faculte des Sciences et Techniques, Universite Cheikh Anta Diop, DAKAR, Senegal., Sidibe Mamadou ,   Laboratoire de Chimie Minerale et Analytique, Departement de Chimie,Faculte des Sciences et Techniques, Universite Cheikh Anta Diop, DAKAR, Senegal., Khadir Diop Abdoul ,   Laboratoire de Chimie Minerale et Analytique, Departement de Chimie,Faculte des Sciences et Techniques, Universite Cheikh Anta Diop, DAKAR, Senegal., Pechev Stanislav ,   X-Ray Department, ICMCB-CNRS, Universite de Bordeaux, 87, Avenue du Dr Albert Schweitzer 33608 PESSAC France.
Published: September 2023

The reaction of Cy2NH2HSeO4.H2Oand SnMe3Cl led to the formation of Cy2NH2SeO4SnMe3 (1), which crystallizes in the orthorhombic space group Pbca with Z = 16, a = 11.59430(10) AÌŠ, b = 19.3138(3)AÌŠ, c = 36.8673(6)AÌŠ, and V = 8255.7(2)AÌŠ3. The asymmetric unit consists of two [SeO 4 SnMe 3 ]- in which the SnMe3 residue is trans coordinated. The complex-anion are linked via NH----O hydrogen bonds which are involved by Cy2NH2+cation. From a supramolecular point of view, the superposition of [SeO4SnMe3]- along a axis are linked by the NH---O of Cy2NH2+cation along c axis giving a tridimensional structure. The characterization of 1 is accompanied by infrared and NMR characterization of two seleniate complexes containing SnMe3 residue to complete the study of reactivity between dialkylammonium seleniate salt and SnMe3Cl molecule.
XERODERMAPIGMENTOSUM: EPIDEMIOLOGICAL, CLINICAL AND THERAPEUTIC ASPECTS
Authors:   In the Plastic Surgery Department CHU Med VI -Marrakech., Benlaaguid K.
Published: September 2023

Xeroderma Pigmentosum (XP) is a rare and disabling genetic dermatosis that was first described in 1874. It is characterized by photo-induced cutaneous alterations, often associated with ocular lesions and sometimes with neurological involvement. The transmission of XP is on an autosomal recessive mode, and it is relatively frequent in countries with high consanguinity rates and large family sizes, such as those in the Maghreb region. This study aims to present an epidemiological, clinical, and histological profile of XP patients treated in the plastic surgery department in southern Morocco, reflecting the regions epidemiological reality and specifying the modalities of oncologic and reparative surgical treatment.
AGRONOMIC CHARACTERIZATION OF SIX TOMATO GENOTYPES IN TOGO
Authors:   Ecole Superieure dAgronomie, Universite de Lome (ESA/UL), B.P. 1515 Lome-Togo., Titilola Akintayo Oluyemi , Banito Agnassim ,   Ecole Superieure dAgronomie, Universite de Lome (ESA/UL), B.P. 1515 Lome-Togo., Tchalla Pouwereou ,   Ecole Superieure dAgronomie, Universite de Lome (ESA/UL), B.P. 1515 Lome-Togo., Katagna Mefeiwai ,   Ecole Superieure dAgronomie, Universite de Lome (ESA/UL), B.P. 1515 Lome-Togo., Donatien Kao Mondomdewa ,   Ecole Superieure dAgronomie, Universite de Lome (ESA/UL), B.P. 1515 Lome-Togo., Kossi Dzinyefa Abotchi Louis ,   Ecole Superieure dAgronomie, Universite de Lome (ESA/UL), B.P. 1515 Lome-Togo., Yves Tanyeto Atekana ,   Ecole Superieure dAgronomie, Universite de Lome (ESA/UL), B.P. 1515 Lome-Togo., Kpegba Kafui ,   Faculte des Sciences, Universite de Lome (FDS/UL), B.P. 1515 Lome-Togo.
Published: September 2023

The study was carried out to determine the agronomic performance of height tomato genotypes. These genotypes were evaluated in a completely random block design with 4 replications. Analyses of variance and means comparison (Pâ‰¤5%) revealed that he germination rate of genotypes was greater than 80% except for TLCV 15 (24%). The number of leaf per plant ranged from 11.62 to 15.73. The largest size was obtained by IVF 328 with 66.34 cm in height and the smallest size was obtained by the TLCV 15 with 51.46 cm. The yield results showed that IVF 328 and Mongal F1 were better with 26.28 tons/ha and 26.07 tons/ha respectively. Regarding the number of fruit per plant, IVF 328 and IVF 5248 were more productive. Analysis of variance showed that the fruit weightwas significantly higher for the Mongal F1 and lower for the TLCV 15. The results obtained will help in decision making toward the production of these genotypes in Togo, thereby improving tomato production.
COST ANALYSIS OF CATH LAB PROCEDURES DONE AT A TERTIARY CARE HOSPITAL OF NORTH INDIA
Authors:   Senior Resident, Department of Hospital Administration, SKIMS, Soura., Rashid Romana , Khalil Ifrah ,   Senior Resident, Department of Hospital Administration, SKIMS, Soura., Mushtaq Younis ,   Associate Program Manager, National Health Mission J&K., Yatoo GH ,   Professor and Head, Department of Hospital Administration, SKIMS, Soura.
Published: September 2023

Cardiovascular Diseases in the community as a whole call for a detailed cost analysis of invasive procedures done in our hospital to have a broad over- view of financial implications these diseases have on people. Methodology:A prospective observational study was carried out for a period of one year to do a cost analysis of invasive cardiac procedures done at our hospital. Results:Costs were divided into direct and in-direct costs. It was found that CAG was the most expensive of all the procedures and material cost incurred was the highest followed by the rest. Conclusion: A well planned team approach is needed to manage these cases within the financial reach of general masses.
EFFECT OF AYURVEDIC TREATMENT ON BIO-MARKERS OFRHEUMATOID ARTHRITIS (RA) : A CASE STUDY
Authors:   M.D. Scholar, PG Department of Kayachikitsa, A & U Tibbia College, University of Delhi., Garg Ish , Prakash Sahu Ved ,   M.D. Scholar, PG Department of Kayachikitsa, A & U Tibbia College, University of Delhi., Singh Rahul ,   M.D. Scholar, PG Department of Kayachikitsa, A & U Tibbia College, University of Delhi., Yadav Sujata ,   H.O.D., Associate professor, PG Department of Kayachikitsa, A & U Tibbia College, University of Delhi.
Published: September 2023

Amavata is a disease caused by vitiation of Vata Dosha associated with formation of Ama (bio-toxin). The Ama combines with Vata Dosha and occupies Sleshmasthana (Asthisandhi) which results in Amavata, producing symptoms like stiffness, swelling and pain in the joints. Amavata is compared with Rheumatoid Arthritis (RA) based on similarities in sign and symptoms. RA is a chronic progressive disease causing inflammation in the joints and resulting in painful deformity and immobility, especially in the fingers, wrists, feet and ankles. The prevalence of Rheumatoid arthritis is approximately 0.8 % of the population (range 0.3 to 2.1%) women are most commonly affected. CASE PRESENTATION: We report the case of a 20 years old female patient experiencing pain in multiple joints along with swelling and stiffness. Patient was investigated with markedly raised level of bio-markers like R.A. Factor, E.S.R., C-Reactive Protein (CRP) and Anti-cyclic citrullinated peptide (anti-CCP) antibody. The patient was administered various Shaman, Deepana and Ama-paachanyogas along with Balukaswedan. The symptoms of Amavata (RA) like Sandhi ruja (joint pain), Sandhishotha (joint swelling) Stabdhata (morning stiffness), and tests like R.A. Factor, ESR, CRP and Anti-CCP were observed over the treatment. Marked improvement were observed in signs and symptoms of Amavata during the course of treatment. Patient was feeling much better than earlier and she felt that about >95% of her symptoms got decreased. No any complication was found during the treatment.
THE SPACE ERAERA FROM THE VIEWPOINT OF PIONEER ARCHITECTS
Authors:   Master of Architectural Engineering., Naeimabadi Shaghayegh
Published: September 2023

The human being developed his life through the context of time by questioning and finding the proper responses, overcoming limitations, and reaching his dreams from ancient till the present and defiantly in the future. When solved the rational problems in all scientific areas and employed the best tools to build the masterpieces. The Architects opened new Free Views in architectural discourses and revolutionized architectural works through the bedrock of machines, electronics, and finally space. In this research I have precisely studied a set of complex resources with an analytical view in order to extract the convergences, results reveal that with the advancement of technology, employing complex computations, interactive robotics, and AI, empowering the aerospace networks, soon we will be able to employ the remote design method deep into the space, as a revolutionary step in the architectural history, so, A Free Volume will settle in the space era.
MYOCARDIAL INFARCTION UNDER METHOTREXATE IN A PATIENT WITH LOW RISK GESTATIONAL TROPHO BLASTIC NEOPLASIA: A CASE REPORT
Authors: Ismaili Mohammed , Siyouri Oumaima , Alaoui Ismaili Khaoula , Stitou Imane , Amaadour Lamiae , Oualla Karima , Benbrahim Zineb , Arifi Samia , Mellas Nawfel
Published: September 2023

Background: Methotrexate, an antifolateantimetabolite, finds extensive application in the field of oncology as well as for managingvariousautoimmunediseases. It isconsidered as backbone treatment for bothlow and high risk, trophoblasticgestationalneoplasia, as mono therapy or in combination withothercytotoxic agents.Whileitisconsideredcardioprotective, datas regardingmethotrexate-inducedcardiomyopathy are rare. we report the case of a woman, initiallydiagnosedwithlow-risk trophoblasticgestationalneoplasia, whosuffered a myocardial infraction after the second course of methotrexate. Case Presentation:A 47-year-old woman, with no othercomorbidities, wasinitiallydiagnosedwith a low-risktrophoblasticgestationalneoplasia, characterized by a Bhcg value of 12,022. Shewasundergoingmethotrexatemonotherapy for the condition. Following the second course of chemotherapy, the patient experiencedchest pain, and an electrocardiogramrevealed an elevation of the ST segment. As a result, thrombolytictreatmentwasadministered at H9 of pain onset.Due to the uncertaintysurrounding the relationbetween Methotrexate and the myocardialinfarction and consideringpotential interactions betweennonsteroidal anti-inflammatorydrugs (NSAIDs) and methotrexate, a decisionwas made to switch to Actinomycin D.The evolutionwas favorable, the patient isstillunder surveillance aftertwoyears of follow up. Conclusion:This case report highlights a possible methotrexateinducedmyocardial infraction. Inthis setting our attitude was to switch for anotherdrug, whichwasverywelltolerated, withgood oncologicincome for our patient.
NEXUS BETWEEN LIQUIDITY MANAGEMENT AND LOAN REPAYMENT AMONG MICROFINANCE BANKS IN EMERGING MARKETS: A PANEL ANALYSIS
Authors:   Phd Candidate, Department of Accounting and Finance, Maseno University., Philbert Caleb Nadebu , Robert Kisavi Mule ,   Department of Accounting and Finance, Maseno University., Destaings Nyenyi Nyongesa ,   Department of Economics, Maseno University.
Published: September 2023

Loan repayment remains the chief source of internally-generated liquidity reserves in the microfinance banks operating in the emerging markets in developing countries. Globally, reports indicate that of the loans disbursed in the United States of America, 45% of borrowers default on repayment, 60% of whom eventually end up as non-performing. A similar trend is reported in Nigeria with statistics indicating growth in overall default rate from USD1.612B in 2017 to USD 2.694B in 2021. Uganda recorded about USD.1.215B worth of non-performing loans in its MFI sector in 2018, from USD 324M in 2017. Microfinance banks (MFBs), as one of the institutions at the center of financial inclusion in Africa target to serve low-end borrowers who are prone to fall in default of honouring their arising loan repayment obligations. In Kenya, MFBs have recorded a steady rise in non-performing loans from Kshs.328M in 2018 to Kshs.1.9B in 2021. The loan repayment trend among MFBs reflects a trajectory that calls for urgent invention measures to secure steady operations to the extent of meeting their arising financial obligations. Previous studies on loan repayment have focused on conventional banking institutions, whose operational lending dynamics are significantly distinct from those of MFB. Existing literature is skewed in favour of investigating parameters associated to profitability. The main objective of this study was to establish the relationship between liquidity management and loan repayment among MFBs in Kenya. The anticipated incometheory underpinned the study objective. Secondary balanced panel data sourced from the annual reports of 12 regulated MFBs in Kenya were used. The study covered an eight-year period from 2015 to 2022, yielding 96 data points. Moderated multiple regression was applied to realize the study objective. Regression results showed that a unit change in liquidity management results in 2.01% significant change in loan repayment (Î²=0.020110, p=0.0085) with R2=82.7%. From the results, the nexus between liquidity management and loan repayment is positive and significant but weak. It is recommended that reliance on strict management of internally generated funds ought to be complemented with moderate external funding.
MGSO4 AND DEXMEDETOMIDINE AS ADJUVANTS TO LOCAL ANAESTHETICS IN BRACHIAL PLEXUS BLOCK (USG GUIDED) FOR UPPER LIMB SURGERY: A COMPARATIVE EVALUATION
Authors: Bhatia Upasna , Shah Vandana , Upadhyay Prachi , Ibrahim Qureshi Mohammed , Gohel Tejal , Rathwa Nitesh
Published: September 2023

Background: Peripheral nerve block has become quite popular in outpatient and inpatient anaesthesia for upper limb procedures due to its safety and unmatched success rate. Supplementing local anaesthetics with adjuvants extends the postoperative time as well as providing intraoperative care. The objective is to assess the effectiveness of bupivacaine and MgSO4 as adjuvants in the supraclavicular brachial plexus block. Methods and Results: 60 Patients were arbitrarily split into two equal groups. 20 mL of 0.5% Bupivacaine with 1 mL of Dexmedetomidine (100 g) were injected into Group D (n = 30), ) and 20 mL of 0.5% Bupivacaine with 1 mL of MgSO4 (250 mg) were injected into Group M (n = 30). Hemodynamic parameters, sedation score, analgesia onset and duration, and satisfaction scores were all chronicled. The onset of sensory block was faster in Group D (5.43 Â± 0.48 min) than in Group M (7.09 Â± 0.14 min). The time of onset of motor block was faster in Group D (8.14 Â± 0.56 min) than in Group M (10.87 Â± 0.71 min) The duration of analgesia was again higher in Group D (1012.2 Â± 24.15min) than in Group M (607.4Â±11.72 min). Conclusions:When compared to patients receiving MgSO4, patients receiving dexmedetomidine have sensory and motor blocks that begin earlier, endure longer, and have smaller postoperative rescue analgesia requirements. With dexmedetomidine, there is a greater frequency but non-significant incidences of hypotension, bradycardia, and better sedation score.
APPLICATION OF THE PRECAUTIONARY PRINCIPLEIN THE MAKING OF AUTHENTIC DEEDS AND LEGAL CONSEQUENCES FOR NOTARIES WHO VIOLATE THE PRECAUTIONARYPRINCIPLE (DECISION STUDY: 261/PID.B/2021/PN IDM)
Authors:   Master Student,FacultyofLaw,JenderalSoedirmanUniversity, Indonesia., Anni Sugiharti Dwi , a Budiyono ,   AssociateProfessor,FacultyofLaw, JenderalSoedirmanUniversity, Indonesia., Wasi Bintoro Rahadi ,   Senior Lecturer, FacultyofLaw,JenderalSoedirmanUniversity, Indonesia., Wahyu Handayani Sri ,   Senior Lecturer,FacultyofLaw, JenderalSoedirmanUniversity, Indonesia.
Published: September 2023

A notary deed, as a product of a public official, must be able to provide certainty regarding an event or fact in the deed actually carried out by a notary. Based on Article 16 of Law Number 2 of 2014 Concerning the Position of Notary Public, paragraph (1) letter (a), in carrying out his position, a notary must apply the principle of prudence. This study examines errors in applying the precautionary principle to the criminal act of forgery in Decision Number 261/Pid.B/2021/PN Idm and the legal consequences for Notaries who violate normative precautionary principles. The results of the study stated that the error in applying the precautionary principle to the crime of forgery in Decision Number 261/Pid.B/2021/PN Idm was intentional the Defendant as a Notary did not introduce the appearer. The defendant also did not carefully verify the subject and object data against the identity of the appearer. The defendant also did not act carefully and thoroughly in the process of making the deed. A notary who violates the principle of prudence in civil terms can be sued for compensation. A notary who is proven to have falsified a statement as an authentic deed is also criminally responsible. Legal consequences for a notary who violates the principle of disciplinary prudence can be in the form of a written warning, temporary dismissal, honorable discharge, or dishonorable dismissal.
THEIMPACTOFPSYCHOMOTOREDUCATIONON CHILDREN'SPRESCHOOL LEARNING
Authors:   LCPM Laboratory, Training Engineering and Didactics of Science and Technology, FS Ben Mâ€™sik, Hassan II University Morocco., Darraj Brahim
Published: September 2023

Introduction: psychomotor education is a pedagogical approach aimed at acquiring knowledge and facilitating school learning by using the child\\\'s motor experience, in particular for the concepts of space, time and energy, by combining the development of the nervous system and educational actions. The general aim of this study was to analyse the influence of psychomotor learning and its effect on young children\\\'s know-how. Methods: This consisted of an analysis of a review of the scientific literature on the concept of psychomotor education and its impact on children\\\'s pre-school learning. To analyse the data, we used a reading grid to describe the importance of psychomotricity in the acquisition of skills necessary for the development of children\\\'s know- how. Results: By analysing several articles on the subject, we were able to describe the impact of psychomotor education on the development of pre-school learning. Conclusion: Our study has enabled us to synthesise a large number of studies in order to analyse the close relationship between psychomotor education and pre- school learning. Key words: psychomotor education, psychomotricity, pre-school learning, logicomathematics.
A SCANNING ELECTRON MICROSCOPY STUDY OF POLLEN GRAINS
Authors:   Department of Botany, Miranda House, University of Delhi, Delhi 110007., Subramanyan Janaki , Bahri Saloni ,   Department of Botany, Miranda House, University of Delhi, Delhi 110007., a Bushra ,   DS Kothari Centre for Research and Innovation in Science Education, Miranda House, University of Delhi, Delhi 110007., Singh Manmeet ,   DS Kothari Centre for Research and Innovation in Science Education, Miranda House, University of Delhi, Delhi 110007., b Prabha ,   DS Kothari Centre for Research and Innovation in Science Education, Miranda House, University of Delhi, Delhi 110007., c Rashmi ,   DS Kothari Centre for Research and Innovation in Science Education, Miranda House, University of Delhi, Delhi 110007.
Published: September 2023

A simple, quick and non-destructive method of preparing fresh pollen grains for scanning electron microscopy (SEM) studies was used in this investigation. The pollen grains of seven taxa belonging to seven families were studied six were dicots, namely Delonix regia, Helianthus annuus, Justicia spicigera,Kigeliaafricana,Lagerstroemia speciosaand Portulaca umbraticola,and one a monocotHymenocallis littoralis. Fresh pollen grains were dehydrated in acidified 2, 2-dimethoxypropane (DMP) followed by criticalpoint drying in carbon dioxide (CO2). In the preliminary study the acidified DMP treated pollen grains were mounted in glycerine and observed under the light microscope. The DMP direct method preserves the original shape of the pollen grains and dissolves the pollen coat thereby enabling observation of the surface ornamentation of the exine. The high magnifications of the SEM provided detailed information about the fine structure or micromorphology of the pollen surface. In the taxa studied the pollen are aperturate and are shed as monads.Among the taxa studied, P.umbraticola was apolar, H.littoralis was heteropolar,and the remaining five were isopolar. The exine was reticulate in D. regia, H.littoralis, J.spicigera, and K.africana echinate in H. annuusandP.umbraticola andfossulate, perforate in L. speciosa.
EVALUATE THE EFFECTIVENESS OF STRUCTURED INSTRUCTIONAL MODULE ON KNOWLEDGE REGARDING FIRST AID MANAGEMENT OF SELECTED EMERGENCIES AMONG ACCREDITED SOCIAL HEALTH ACTIVISTS (ASHES) IN SELECTED RURAL AREAS OF PHC, BIDADI
Authors:   Sri Deva Raj Urs College of Nursing Tamaka, Kolar Kolar District, Karnataka India., M.C Tanuja , Begum Aysha ,   Sri Deva Raj Urs College of Nursing Tamaka, Kolar Kolar District, Karnataka India.
Published: September 2023

First aid management of selected emergencies is a discipline with a broad scope involving many specialized fields in its most general sense.According to the Biomedical report, unintentional injury caused 648 000 deaths (7% of all deaths 58/100 000 population). SinceFirst aid personnel is persons on the spot, generally, peripheral health workers who are familiar with the specific conditions of work and who might not be medically qualified but must be trained and prepared to perform particular tasks. Hence creating awareness in the prevention of emergencies is very important. First aid personnel should be selected carefully, taking into account attributes such as reliability, motivation, and the ability to cope with people and availability in a crisis situation.5 Present study attempts to evaluate the effectiveness of structured instructional module on Knowledge regarding first aid management of selected emergencies among Accredited social health activists(ASHAs) at selected rural areas of PHC, Bidadi.
ENTREPRENEURIAL INTENTION: A REVIEW OF THE ELEMENTS THAT PUSH AND PULL THE COMMERCE MAJORS INTO ENTREPRENEURIAL LEAP
Authors:   Assistant Professor Department of Commerce, Bora Institute of Management Sciences, Lucknow, U.P., India., Tewari Anubhav
Published: September 2023

Purpose: With an emphasis on its antecedents and determinants to develop intention of start-up, this research paper gives a synopsis of the constantly expanding literature on motivator and impediment elements. Methodology: Due to desire of Independence need for Achievement & Recognition and foundational understanding of business, students with a background of commerce are drawn to entrepreneurship. Research participants in this study are 324 of both genders all of them came from college/ universities in the state of Uttar Pradesh. In this study, a structured questionnaire is used. Following the screening of the data, the data were analyzed using SPSS to determine the validity, reliability, and modal test like Chi Square Test of Independence and Mann-Whitney U-Test (alternative to independent samples T-test) of all the components, which were then used to investigate the outcomes. These tests are used due to safer side of problem of normality of data. Findings: This research paper is delves into the push and pull factors, and the subsequent intention to establish a start-up, examining the part played by factors influencing opportunity recognition. Author speculates on potential future directions for studying opportunity recognition. It became obvious that people are motivated by a wide variety of variables which are taking birth due to effect of push and pull factors it might be individual or both. These cravings are mostly influenced by education, age and gender, among other factors. Finally, current researchs findings provide substantial evidence of a preference among male students for pull variables and a preference among female students for push variables. Research limitations/ implications: The current study only used a fraction of students with some familiarity with the commerce stream. A greater sample size of students from a variety of socio-economic backgrounds and locations, as well as more inspiring and ambient components, will allow researchers to perform relevant study. Practical implications: The findings of this study offer concrete advice for educators looking to better equip their students for successful forays into the startup world.
Monthly runoff prediction using the VMD-LSTM-Transformer hybrid model: a case study of the Miyun Reservoir in Beijing
Authors: Guo Shaolei , Wen Yihao , Zhang Xianqi , Chen Haiyang
Published: September 2023

Accurate runoff prediction is of great significance for flood prevention and mitigation, agricultural irrigation, and reservoir scheduling in watersheds. To address the strong non-linear and non-stationary characteristics of runoff series, a hybrid model of monthly runoff prediction, variational mode decomposition (VMD)–long short-term memory (LSTM)–Transformer, is proposed. Firstly, VMD is used to decompose the runoff series into multiple modal components, and the sample entropy of each modal component is calculated and divided into high-frequency and low-frequency components. The LSTM model is then used to predict the high-frequency components and the transformer to predict the low-frequency components. Finally, the prediction results are summed to obtain the final prediction results. The Mann–Kendall trend test method is used to analyze the runoff characteristics of the Miyun Reservoir, and the constructed VMD–LSTM–Transformer model is used to forecast the runoff of the Miyun Reservoir. The prediction results are compared and evaluated with those of VMD–LSTM, VMD–Transformer, empirical mode decomposition (EMD)–LSTM–Transformer, and empirical mode decomposition (EMD)–LSTM models. The results show that the Nash–Sutcliffe efficiency coefficient (NSE) value of this model is 0.976, mean absolute error (MAE) is 0.206 × 107 m3, mean absolute percentage error (MAPE) is 0.381%, and root mean squared error (RMSE) is 0.411 × 107 m3, all of which are better than other models, indicating that the VMD–LSTM–Transformer model has higher prediction accuracy and can be applied to runoff prediction in the actual study area.
The Potential of Leucomethylene Blue in Methemoglobinemia Treatment: A New Hope for Patients with G6PD?
Authors: Emadi Elaheh , Alamdari Daryoush Hamidi , Sahebkar Amirhossein
Published: September 2023

Methylene blue (MB) has been routinely used to treat methemoglobinemia. In
the body, MB is reduced to leucomethylene blue (LMB) by NADPH-dependent methemoglobin
(MetHB) reductase, and then LMB reduces Fe3+ to Fe2+. In glucose-6-phosphate
dehydrogenase (G6PD) deficiency, NADPH is not produced sufficiently to protect erythrocytes
against oxidative stress and to take part in relevant biochemical reactions. Since
MB is an oxidative agent, its administration in individuals with G6PD deficiency leads to
an increased risk of hemolysis through oxidative stress and even death. Therefore, its administration
has been prohibited from treating methemoglobinemia in G6PD patients. As
an antioxidant and direct reducing agent for Fe3+, LMB may be prescribed for treating
MetHB in patients with G6PD deficiency. Considering the biochemical process of turning
MB into LBM and the reducing nature of LMB, it seems LMB is a safer drug than MB in
treating methemoglobinemia. LMB can even be administrated in other treatments without
any concern about increasing oxidative stress, exacerbating the inflammation. Proof-ofconcept
experimental and clinical trials could substantiate this hypothesis.
Ruthenium-catalyzed Olefin Metathesis in Water using Thermo-responsive Diblock
Copolymer Micelles
Authors: Suzuki Noriyuki , Watanabe Ken , Takahashi Chirika , Takeoka Yuko , Rikukawa Masahiro
Published: September 2023

Ruthenium-catalyzed olefin metathesis reactions were conducted in water with thermoresponsive
block copolymers forming micelles. The block copolymers were prepared by living radical
polymerization and consisted of a thermo-responsive and hydrophilic segments. The former
segment included poly(N-isopropylacrylamide) or poly(N,N-diethylacrylamide), and the latter
poly(sodium 4-styrene sulfonate), poly(sodium 2-acrylamido-2-methylpropanesulfonate) or
poly(ethylene glycol). Homometathesis, cross-metathesis and ring-closing metathesis reactions proceeded
to afford the products in moderate to good yields. Extraction efficiency from the reaction
mixture was also studied.
Sodium-glucose Cotransporter 2 Inhibitors and Pathological Myocardial
Hypertrophy
Authors: Gao Zhicheng , Bao Jiaqi , Hu Yilan , Tu Junjie , Ye Lifang , Wang Lihong
Published: September 2023

Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new type of oral hypoglycemic
drugs that exert a hypoglycemic effect by blocking the reabsorption of glucose in the proximal
renal tubules, thus promoting the excretion of glucose from urine. Their hypoglycemic effect is
not dependent on insulin. Increasing data shows that SGLT2 inhibitors improve cardiovascular outcomes
in patients with type 2 diabetes. Previous studies have demonstrated that SGLT2 inhibitors
can reduce pathological myocardial hypertrophy with or without diabetes, but the exact mechanism
remains to be elucidated. To clarify the relationship between SGLT2 inhibitors and pathological
myocardial hypertrophy, with a view to providing a reference for the future treatment thereof, this
study reviewed the possible mechanisms of SGLT2 inhibitors in attenuating pathological myocardial
hypertrophy. We focused specifically on the mechanisms in terms of inflammation, oxidative
stress, myocardial fibrosis, mitochondrial function, epicardial lipids, endothelial function, insulin
resistance, cardiac hydrogen and sodium exchange, and autophagy.