bluuebunny/crossref_metadata_2025 huggingface dataset:
The development and validation of the assessment engagement scale
Authors: Evans Carol , Zhu Xiaotong
Published: June 2023

Introduction

The quality of student engagement in assessment within higher education affects learning outcomes. However, variations in conceptions of what quality in engagement looks like impacts assessment design and the way that students and lecturers engage with each other in the assessment process. Given that assessment is an important driver of student engagement in higher education, it is surprising that no specific measures to support understanding of this measure exist. To address this significant gap, we outline the evolution of an assessment engagement scale derived from a research-informed conceptual framework utilizing best practice in assessment and feedback.

Methods

We consider the validity and utility of the assessment engagement scale in supporting students’ understanding of assessment and their role within it using exploratory and confirmatory factor analyses.

Results

The resultant nine-item assessment engagement scale’s underpinning two factors included: (i) Understanding of the Assessment Context (UAC) including one’s role within it, and confidence in navigating assessment requirement, and (ii) Realising Engagement Opportunities (REO) (i.e., willingness to engage and ability to utilise the assessment context effectively to support one’s understanding). Construct, criterion, and convergent validity of the scale were established.

Discussion

The AES is a powerful tool in promoting dialogue between lecturers and students about what high quality engagement in assessment looks like, and the respective roles of all parties in realising this. Implications for assessment practices are discussed along with the potential of the scale as a predictive and developmental tool to support enhancements in assessment design and student learning outcomes in higher education.
Utility of a slopes difference test for probing longitudinal multilevel aptitude treatment interactions: a simulation
Authors: DeJong Trey L. , Chen Qi
Published: June 2023

To determine which interventions work best for which students, precision education researchers can examine aptitude-treatment interactions (ATI) or skill-by-treatment interactions (STI) using longitudinal multilevel modeling. Probing techniques like the slopes difference test fit an ATI or STI framework, but power for using slopes difference tests in longitudinal multilevel modeling is unknown. The current study used simulation to determine which design factors influence the power of slopes difference tests. Design factors included effect size, number of waves, number of clusters, participants per cluster, proportion of assignment to the treatment group, and intraclass correlation. Of these factors, effect size, number of waves, number of clusters, and participants per cluster were the strongest determinants of power, model convergence, and rates of singularity. Slopes difference tests had greater power in longitudinal multilevel modeling than where it is originally utilized: multiple regression.
The polyfactorial model of autism and the question of causality
Authors: Golse Bernard
Published: June 2023

After recalling the different pediatric, psychopathological and child psychiatric models of mental disorders in children and adolescents, the author presents in detail the so-called polyfactorial model, which includes primary, secondary, and mixed factors. This model is the epistemological heir of the Freudian concept of “complementary series.” The example of autism is then explored as a paradigm of the usefulness of this polyfactorial model. Finally, we reflect on the notion of causality, from Aristotelian causality to epigenetic causality, which could 1 day re-legitimize psychoanalysis and the impact of the relationship on genome expression.
Effect of Shi-Zhen-An-Shen herbal formula granule in the treatment of young people at ultra-high risk for psychosis: a pilot study
Authors: Zhu Hong , Ning Yanzhe , Zheng Sisi , Feng Sitong , Dong Linrui , Jia Hongxiao
Published: June 2023

Introduction

To date, there is no conclusive evidence for early interventions on ultra-high risk (UHR) for psychosis. The Chinese herbal medicine is confirmed to be beneficial in improving psychiatric symptoms and cognitive impairments for schizophrenia patients. However, the effect of Chinese herbal medicine on treating UHR patients remains unknown.

Methods

Eighty UHR patients were recruited from the outpatient department. They were randomly assigned to receive either Shi-Zhen-An-Shen herbal formula granule (SZAS-HFG) combined with aripiprazole placebo or aripiprazole combined with SZAS-HFG placebo for a 12-week treatment. The psychiatric symptoms were assessed using the Structured Interview for Prodromal Syndromes (SIPS). The Trail Making Test part A (TMT-A), Brief Visuospatial Memory Test (BVMT), Hopkins Verbal Learning Test (HVLT), and Continuous Performance Test (CPT) were used to assess cognitive functions. we also employed the Global Assessment of Functioning (GAF) to evaluate social functioning. The linear mixed-effects models were performed to detect the difference in effectiveness between the two groups.

Results

After 12-week treatment, both groups showed significant effects of time on SIPS, TMT-A, HVLT, BVMT, and GAF. There was a significant effect of group only on CPT. Moreover, we also found a significant interaction effect on GAF.

Conclusion

SZAS-HFG can effectively alleviate psychosis symptoms, and improve cognitive impairments and overall functioning as well as aripiprazole.

Clinical trial registration: Chinese Clinical Trial Registry, ChiCTR-IOR-17013513.
Health promotion networks in two districts in Bavaria, Germany: an exploratory case study mapping networks with respect to thematic agenda and location
Authors: Fehrmann Annika Marie , Steinbeisser Kathrin , Wolff Andrea R. , Coenen Michaela
Published: June 2023

Introduction

Building networks is an essential part of health promotion. However, network analysis remains relatively unexplored in this field. This study introduces a new technique that maps thematic agendas and geographical locations of health promotion actors.

Methods

This case study used elements of quantitative and qualitative methods to analyse network data. We used empirical data from two networks in Bavaria, a federal state of Germany.

Results

We identified a total of 55 actors in the first network and 64 actors in the second. We categorized the thematic agenda of actors according to their main field of work: “healthy childhood development,” “healthy middle age phase,” “healthy ageing,” “health equity in all phases of life.” One network showed a significant surplus of actors that focus on “healthy ageing.” We combined and analysed data from both networks collectively. Two districts with no health promotion actors within their geographical borders were identified. To put geographical gaps into context, data about deprivation and age was included.

Discussion

Results identified geographical areas with high need for support from health promotion actors. Through comparison of our results with existing literature, we derived potential network strategies for further successful networking. This study adds a new perspective to characterize health promotion networks by mapping them thematically and geographically. The concept can be used to give health promotion organisations relevant insight into network structures. This can improve decision-making processes concerning partnership strategy and finally lead to a positive health impact. Hence, our findings encourage further development of this technique and other networking methods in the field of health equity and health promotion.
Compliance with health protocols in the banking sector facing Covid-19
Authors: Ghavamabadi Leila Ibrahimi , Shabab Mitra , Dehaghi Behzad Fouladi , Hoveizi Farkhondeh
Published: June 2023

Background

The spread of the coronavirus has become one of the current challenges in the world. Implementing health protocols in the workplace along with informing people who face them, has become a vital issue.

Objective

The purpose of this study was to determine the level of compliance with health protocols and measure the level of awareness, attitude and performance of bank employees while facing Covid-19.

Materials and methods

The data collection tool included a checklist and two questionnaires (demographic information and the other on the awareness, attitude and performance of bank staff) regarding the coronavirus.

Results

A total of 199 bank employees from 25 bank branches participated in the study. The results showed that in 24% of the bank branches, the staff did not use face masks. And 100% of the studied bank branches lacked proper ventilation. The mean awareness scores of female employees (94.3) were significantly higher than those of male employees (87.7). Also, the performance of female employees (93.2) was significantly better than male employees (87.2).

Conclusion

The results showed that to achieve proper performance in controlling and reducing the covid-19 disease among bank employees and other workers, these items are noteworthy: (1) Providing and training the correct use of protective equipment including face masks. (2) Monitoring for strict implementation of health protocols. Therefore, it is necessary to keep training and information up-to-date due to the new phenomena of this disease.
Mental health knowledge and classroom experiences of school teachers in Aragon, Spain
Authors: Granada-López José Manuel , Ramón-Arbués Enrique , Echániz-Serrano Emmanuel , Juárez-Vela Raúl , Cobos-Rincón Ana , Satústegui-Dordá Pedro José , Navas-Echazarreta Noelia , Santolalla-Arnedo Iván , Nash Michael
Published: June 2023

Background

Research shows that many mental disorders begin in childhood but are sometimes not diagnosed until later years. School-age children spend much of their time in schools and have daily interactions with school teachers.

Aim

Examine school teachers’ experiences of mental disorders in school going children and adolescents and their associated mental health training needs.

Method and sample

A descriptive cross-sectional study was carried out with teachers in Infant-Primary and Secondary Education-Baccalaureate schools.

Results

A convenience sample of 685 teachers responded to the online survey. Participants worked in both urban and rural areas and in Infant-Primary and Secondary Education-Baccalaureate schools. Over half of participants reported classroom experiences of learner mental disorders such as ADHD, anxiety, conduct disorders or autism. Most participants acknowledged a training need, both in recognition of symptoms of mental disorders and in care resources and processes. However, 80% of respondents reported having not received any training in this regard. Participant preferences for training included face-to-face or hybrid – combined online learning. Participants also considered the management of their own mental health to be deficient, therefore any training should incorporate personal mental health awareness and self-help strategies.

Conclusion

In Aragón (Spain), teachers of children and adolescents with mental disorders, recognize a need for training in the identification of symptoms and other aspects of mental healthcare, such as availability and access to services. Protocols for early identification and referral would promote mentally healthy school environments and reduce stigma which could be a barrier to timely intervention. In addition, any training should include mental health self-care for teachers.
Cassava mosaic disease in South and Southeast Asia: current status and prospects
Authors: Hareesh Padinjarepulikkiyil Sankaran , Resmi Thulasi Raveendrannair , Sheela Madhavi N. , Makeshkumar Thangaraj
Published: June 2023

Cassava is one of the most important food and industrial crops in Asia, Africa, and South America. Cassava mosaic disease (CMD), caused by cassava mosaic geminivirus, is one of the major constraints to cassava cultivation. In Asia, the disease is caused by the Indian cassava mosaic virus and Sri Lankan cassava mosaic virus. Phytosanitation, vector control, breeding, and genetic engineering strategies have been widely adopted to manage the disease. This study provides a comprehensive review of the disease spread, the development of diagnostic methods, and various approaches employed for the management of CMD in South and Southeast Asia.
Cultural and economic barriers and opportunities for the participation of women in agricultural production systems: a case study in Guatemala
Authors: Hernandez Manuel A. , Alarcon Constanza , Berrospi Maria Lucia , Lopera Diana , Quintero Diana , Reyes Byron , Olivet Francisco
Published: June 2023

As in other Latin American countries, agricultural activities in Guatemala contribute with 32% of the total employment (65% in rural areas), but only one in every ten individuals employed in these activities are women. This study examines the cultural and economic barriers and opportunities for the participation of women in agricultural (crop and livestock) production systems. We rely on a qualitative approach involving focus group discussions with 15–20 women in each of the eight communities visited in the departments of Chiquimula (Dry Corridor) and Huehuetenango (Western Highlands) in October 2022. The study provides several interesting findings, which generally hold across locations. First, women do not seem to have a strong preference for crop production activities, except harvesting, and only get involved in specifically assigned tasks. This lack of interest and participation in crop-related activities, which can be related to low empowerment levels and traditional stereotypes in the community about gender roles, persist even in locations with a higher emigration of men, where women could be expected to take over traditionally male crop-related tasks. Second, participants carry out a variety of other unpaid activities, including raising small-scale livestock and maintaining home gardens, which they do not recognize as formal, income-generating occupations despite their more active role. Third, women consider the commercialization of their products a persistent challenge as they do not have access to markets beyond their community, which additionally results in a deterrent to applying for credits due to a generalized fear of defaulting. Despite their day-to-day economic hardship, participants’ main aspirations point to generating more income in non-crop-related activities, mainly livestock farming and raising, or, alternatively, emigrating to provide a better future for their children. These findings remark the importance of offering extensive support to women to not only start new activities, as it has been the case of several public and private initiatives in the area, but help them through continuous extension services on production, storage, and commercialization; management and accounting; and financial literacy, as well as on building agency capacity through existing women groups and organizations and enabling the environment for improved access to markets and credit.
Case report: Immediate revascularization for symptomatic hepatic artery pseudoaneurysm after orthotopic liver transplantation? A case series and literature review
Authors: Lerut An Verena , Pirenne Jacques , Sainz-Barriga Mauricio , Blondeel Joris , Maleux Geert , Monbaliu Diethard
Published: June 2023

Introduction

Hepatic artery pseudoaneurysm (HAPA), a rare vascular complication that can develop after liver transplantation, is associated with a high mortality rate and graft loss. To salvage the liver graft, immediate revascularization, either through surgical or endovascular intervention, is required. However, currently there is no consensus on the optimal strategy. Here, we report three cases of liver transplant recipients diagnosed with HAPA and treated with immediate revascularization. In addition, we present an overview of HAPA cases described in the literature and make recommendations on how to treat this rare complication.

Methods

All adults transplanted in our center between 2005 and 2021 were retrospectively reviewed. Literature search was done in PubMed for original studies between 1980 and 2021 reporting early hepatic artery (pseudo) aneurysm after liver transplantation requiring either surgical or endovascular intervention.

Results

From a total of 1,172, 3 liver transplant patients were identified with a symptomatic HAPA and treated with immediate revascularization. HAPA occurred 73, 27, and 8 days after liver transplantation and was treated with immediate revascularization (two surgical and one endovascular intervention). Literature review identified 127 cases of HAPA. HAPA was managed with endovascular therapy in 20 cases and by surgical intervention in 89 cases. Overall reported mortality rate was 39.6%, whereas overall graft survival was 45.2%.

Conclusion

Immediate surgical or radiological interventional excision and prompt revascularization to salvage liver grafts is feasible but still associated with a high mortality.
Exploration of Mediators Associated with Myocardial Remodelling in Feline Hypertrophic Cardiomyopathy
Authors: Cheng Wan-Ching , Lawson Charlotte , Liu Hui-Hsuan , Wilkie Lois , Dobromylskyj Melanie , Luis Fuentes Virginia , Dudhia Jayesh , Connolly David J.
Published: June 2023

Hypertrophic cardiomyopathy (HCM) affects both humans and cats and exhibits considerable interspecies similarities that are exemplified by underlying pathological processes and clinical presentation to the extent that developments in the human field may have direct relevance to the feline disease. Characteristic changes on histological examination include cardiomyocyte hypertrophy and interstitial and replacement fibrosis. Clinically, HCM is characterised by significant diastolic dysfunction due to a reduction in ventricular compliance and relaxation associated with extracellular matrix (ECM) remodelling and the development of ventricular hypertrophy. Studies in rodent models and human HCM patients have identified key protein mediators implicated in these pathological changes, including lumican, lysyl oxidase and TGF-β isoforms. We therefore sought to quantify and describe the cellular location of these mediators in the left ventricular myocardium of cats with HCM and investigate their relationship with the quantity and structural composition of the ECM. We identified increased myocardial content of lumican, LOX and TGF-β2 mainly attributed to their increased expression within cardiomyocytes in HCM cats compared to control cats. Furthermore, we found strong correlations between the expressions of these mediators that is compatible with their role as important components of cellular pathways promoting remodelling of the left ventricular myocardium. Fibrosis and hypertrophy are important pathological changes in feline HCM, and a greater understanding of the mechanisms driving this pathology may facilitate the identification of potential therapies.
Dispersion and Radiation Modelling in ESTE System Using Urban LPM
Authors: Lipták Ľudovít , Čarný Peter , Marčišovský Michal , Marčišovská Mária , Chylý Miroslav , Fojciková Eva
Published: June 2023

In cases of accidental or deliberate incidents involving a harmful agent in urban areas, a detailed modelling approach is required to include the building shapes and spatial locations. Simultaneously, when applied to crisis management, a simulation tool must meet strict time constraints. This work presents a Lagrangian particle model (LPM) for computing atmospheric dispersion. The model is implemented in the nuclear decision support system ESTE CBRN, a software tool developed to calculate the atmospheric dispersion of airborne hazardous materials and radiological impacts in the built-up area. The implemented LPM is based on Thomson’s solution for the nonstationary, three-dimensional Langevin equation model for turbulent diffusion. The simulation results are successfully analyzed by testing compatibility with Briggs sigma functions in the case of continuous release. The implemented LPM is compared with the Joint Urban 2003 Street Canyon Experiment for instantaneous puff releases. We compare the maximum concentrations and peak times measured during two intensive operational periods. The modeled peak times are mostly 10–20% smaller than the measured. Except for a few detector locations, the maximum concentrations are reproduced consistently. In the end, we demonstrate via calculation on single computers utilizing general-purpose computing on graphics processing units (GPGPU) that the implementation is well suited for an actual emergency response since the computational times (including dispersion and dose calculation) for an acceptable level of result accuracy are similar to the modeled event duration itself.
Kick Cat Effect: Social Context Shapes the Form and Extent of Emotional Contagion
Authors: Zhang Ling , Chen Ying , Wei Yanqiu , Leng Jie , Kong Chao , Hu Ping
Published: June 2023

Emotional contagion refers to the transmission and interaction of emotions among people. Researchers have mainly focused on its process and mechanism, often simplifying its social background due to its complexity. Therefore, in this study, we attempt to explore whether the presence and clarity of social context affect emotional contagion and the related neural mechanisms. In Experiment 1, participants were asked to report their subjective experiences after being exposed to the facial expressions of emotional expressers, with or without the corresponding social context being presented. The results revealed that positive or negative expressions from the expressers elicited corresponding emotional experiences in the receivers, regardless of the presence of social context. However, when the social context was absent, the degree of emotional contagion was greater. In Experiment 2, we further investigated the effect of the clarity of social contexts on emotional contagion and its neural mechanisms. The results showed an effect consistent with those in Experiment 1 and highlighted the special role of N1, N2, P3, and LPP components in this process. According to the emotions as social information theory, individuals may rely more on social appraisal when they lack sufficient contextual information. By referencing the expressions of others and maintaining emotional convergence with them, individuals can adapt more appropriately to their current environment.
Effectiveness of Enhanced Self-Positivity Bias Training in Mitigating Depressive Mood following Negative Life Events
Authors: Wang Lingyun , Song Xiaoling , Jia Fanli , Xue Wenxia , Li Lihong
Published: June 2023

The phenomenon of self-positivity bias refers to the common tendency for individuals to perceive themselves in a more positive light than is objectively warranted. The current study seeks to investigate the impact of enhanced self-positivity bias on depressive mood resulting from negative life events. The study included two experiments, a resistance experiment (exp. 1) and an improvement experiment (exp. 2), with 40 randomly selected college students randomly assigned to either a self-positive bias training group or a neutral training group in each experiment. In the resistance experiment, self-positive bias training was conducted before failure feedback, while in the improvement experiment, it was conducted after failure feedback. The results showed that failure feedback significantly increased depression levels among college students, and self-positive bias training improved the level of self-positive bias. In the resistance experiment, there was no significant difference between the self-positive bias training group and the neutral training group regarding depression. However, in the improvement experiment, being in the self-positive bias training group had a significantly greater effect on improving depression compared to the neutral training group. Overall, the findings suggest that while self-positive bias training cannot prevent depression caused by failure events, it has a positive effect on improving depression.
Risk Control of Energy Performance Fluctuation in Multi-Unit Housing for Weather Uncertainty
Authors: Wang Jiahe , Mae Masayuki , Taniguchi Keiichiro
Published: June 2023

With the acceleration of urban development, the population density of urban cities has increased. As the spatial characteristics of multi-unit housing (MUH) perfectly fit this developmental trend and, simultaneously, have high energy efficiency, the number of MUHs has increased rapidly in recent decades. Although many studies have proposed high energy efficiency strategies, weather uncertainty leads to errors between the operational performance of building energy and simulated values. This study introduces a robust optimization framework that incorporates uncertainty considerations into the optimization process to suppress energy consumption fluctuations and improve the average building energy consumption performance. Neural networks are used to model the uncertainty of multiple weather elements as normal distributions for each hour, and the accuracy of the uncertainty model is validated by calculating the mean absolute percentage error (MAPE) between the mean values of the distribution and the measurement values, which ranges from 3% to 13%. The clustering algorithm is proposed to replace the sampling method to complete the sampling work from the normal distribution space of the weather elements to serve the subsequent optimization process. Compared with the traditional method, the sampling results of the clustering algorithm show better representativeness in the sample space. The robust optimization results show that the average energy consumption of the optimal scheme decreases by 13.4%, and the standard deviation decreases by approximately 17.2%, which means that the optimal scheme, generated by the robust optimization framework proposed in this study, has lower average energy consumption results and a more stable energy consumption performance in the face of weather uncertainty.
The Role of Stress States on the Hysteric Behavior of Expansive Soil under Multiple Drying-Wetting Cycles
Authors: Al-Mahbashi Ahmed M. , Elkady Tamer , Al-Shamrani Mosleh
Published: June 2023

Expansive soils in the field are typically exposed to cyclic wetting and drying due to climatic fluctuations and subjected to a variety of stress conditions in nature or when used as compacted layers for the construction of hydraulic barriers or waste disposal facilities. The hysteric behavior of the soil-water characteristic curve (SWCC) is a key parameter for understanding, modeling, and interpreting the unsaturated behavior of these soils under such conditions. This study investigates the effect of stress states on the hysteresis behavior of soil-water characteristic curves (SWCCs) for compacted highly expansive clay over a range of matric suction between 0 and 1500 kPa. Two test series were performed, the first test series investigated the effect of stress states on the hysteresis of SWCCs during a single drying-wetting (DW) cycle. The second test series studied the combined effect of stress applied and multiple drying-wetting cycles on the SWCC hysteresis. For the sake of comparison, the overall SWCC hysteresis due to drying-wetting cycles was quantified using the average degree of hysteresis in terms of volumetric water content (ADHθ). Furthermore, contributors to the observed hysteresis were defined using two newly proposed measures; namely, average degree hysteresis in terms of gravimetric water content (ADHw) and in terms of volume change (ADHe*). The outcomes of this study indicate that consideration of stress states on the hysteresis of SWCC for expansive clay is of great importance. The results show a dual trend for the variation of ADHθ with applied vertical stress. Furthermore, multiple DW cycles induced a significant reduction in the hysteresis (ADHθ) under low- and high-stress states up to a certain level of DW cycles, then, no further changes in the hysteresis trend were detected. It was also found that hysteresis loops under a low-stress state were concentric in shape while hysteresis loops for specimens under a high-stress state were non-concentric, with a downward shift in hysteresis loops with the increase in DW cycles.
An Agreement Analysis on the Perception of Property Stakeholders for the Acceptability of Smart Buildings in the Nigerian Built Environment
Authors: Alohan Ernest O. , Oyetunji Abiodun Kolawole , Amaechi Chiemela Victor , Dike Emmanuel Chigozie , Chima Pius
Published: June 2023

The introduction of intelligent devices in buildings has brought about tremendous changes into the construction industry. The use of automation is also gradually gaining interest from the stakeholders involved in the built environment. This paper presents the perception of property stakeholders (property valuers/real estate developers and service users) regarding the acceptability of smart buildings as a future built environment in Nigeria, using Benin City a case study. A total of 159 structured questionnaires were administered with 108 retrieved and valid for analysis. The information sourced from the respondents includes smart building awareness, the support for, drivers to, and limitations of its implementation, the willingness to develop smart buildings, and the willingness to pay proportionate rent to occupy smart properties. The findings showed that the poll of respondents for the property valuers and the real estate developers, as well as the service users, claimed to be aware of the concept, and they also support its development in the country. The drivers and limitations were ranked based on their perceived level of significance. This study recommends the promotion of awareness to accelerate its acceptance and implementation. This will help propagate the process of creating a smart city in developing nations such as Nigeria and prepare property valuers professionally for its management.
Barriers and Solutions to Green Facade Implementation—A Review of Literature and a Case Study of Leipzig, Germany
Authors: Knifka Wiebke , Karutz Raphael , Zozmann Heinrich
Published: June 2023

The expansion of green infrastructure through vertical forms of greenery is an innovative way to address urban sustainability challenges. Despite various social, economic, and environmental benefits, however, facade greening is rarely implemented. This article examines barriers to and solutions for the implementation of green facades through a systematic literature review and a participatory case study of Leipzig, Germany. We found a total of 24 social, political-administrative, economic, practical-technical, and environmental barriers hindering key actors to (successfully) implement green facades. The lack of information and knowledge was found to be an underlying issue. Solutions co-created with local stakeholders and experts include the provision of informative, regulatory, and financial incentives, the adaptation of political-administrative strategies, regulations, and procedures, as well as the support of the practical-technical implementation process through information and experts. To overcome barriers, various measures must be combined, but establishing public relations and advisory services on green facades is of priority in Leipzig. By combining insights from academic literature with applied knowledge of a diverse group of local actors, we identify how barriers to facade greening may be overcome in the specific case of a major German city and provide a blueprint for similar research in other socio-political contexts.
End-of-Life Care in the Last Three Months before Death in Older Patients with Cancer in Belgium: A Large Retrospective Cohort Study Using Data Linkage
Authors: Depoorter Victoria , Vanschoenbeek Katrijn , Decoster Lore , Silversmit Geert , Debruyne Philip R. , De Groof Inge , Bron Dominique , Cornélis Frank , Luce Sylvie , Focan Christian , Verschaeve Vincent , Debugne Gwenaëlle , Langenaeken Christine , Van Den Bulck Heidi , Goeminne Jean-Charles , Teurfs Wesley , Jerusalem Guy , Schrijvers Dirk , Petit Bénédicte , Rasschaert Marika , Praet Jean-Philippe , Vandenborre Katherine , De Schutter Harlinde , Milisen Koen , Flamaing Johan , Kenis Cindy , Verdoodt Freija , Wildiers Hans
Published: June 2023

This study aims to describe end-of-life (EOL) care in older patients with cancer and investigate the association between geriatric assessment (GA) results and specialized palliative care (SPC) use. Older patients with a new cancer diagnosis (2009–2015) originally included in a previous multicentric study were selected if they died before the end of follow-up (2019). At the time of cancer diagnosis, patients underwent geriatric screening with Geriatric 8 (G8) followed by GA in case of a G8 score ≤14/17. These data were linked to the cancer registry and healthcare reimbursement data for follow-up. EOL care was assessed in the last three months before death, and associations were analyzed using logistic regression. A total of 3546 deceased older patients with cancer with a median age of 79 years at diagnosis were included. Breast, colon, and lung cancer were the most common diagnoses. In the last three months of life, 76.3% were hospitalized, 49.1% had an emergency department visit, and 43.5% received SPC. In total, 55.0% died in the hospital (38.5% in a non-palliative care unit and 16.4% in a palliative care unit). In multivariable analyses, functional and cognitive impairment at cancer diagnosis was associated with less SPC. Further research on optimizing EOL healthcare utilization and broadening access to SPC is needed.
Cystic Clear Cell Renal Cell Carcinoma: A Morphological and Molecular Reappraisal
Authors: Pini Giacomo Maria , Lucianò Roberta , Colecchia Maurizio
Published: June 2023

A wide variety of renal neoplasms can have cystic areas. These can occur for different reasons: some tumors have an intrinsic cystic architecture, while others exhibit pseudocystic degeneration of necrotic foci or they have cystically dilated renal tubules constrained by stromal neoplastic cells. Clear cell renal cell carcinoma (CCRCC), either solid or cystic, is the most frequent type of renal cancer. While pseudocysts are found in high-grade aggressive CCRCC, cystic growth is associated with low-grade indolent cases. The latter also form through a cyst-dependent molecular pathway, and they are more frequent in patients suffering from VHL disease. The differential diagnosis of multilocular cystic renal neoplasm of low malignant potential and clear cell papillary renal cell tumor can be especially hard and requires a focused macroscopical and microscopical pathological analysis. As every class of renal tumor includes cystic forms, knowledge of the criteria required for a differential diagnosis is mandatory.
Fluorometric Quantification of Total Cell-Free DNA as a Prognostic Biomarker in Non-Small-Cell Lung Cancer Patients Treated with Immune Checkpoint Blockade
Authors: Oliver Javier , Onieva Juan Luis , Garrido-Barros María , Cobo-Dols Manuel , Martínez-Gálvez Beatriz , García-Pelícano Ana Isabel , Dubbelman Jaime , Benítez José Carlos , Martín Juan Zafra , Cantero Alejandra , Pérez-Ruiz Elisabeth , Rueda-Domínguez Antonio , Barragán Isabel
Published: June 2023

The present study aimed to investigate the potential of basal cell-free fluorometric DNA (cfDNA) quantification as a prognostic biomarker in advanced non-small cell lung cancer (NSCLC) patients treated with an Immune Checkpoint Blockade (ICB). A discovery and validation cohort of 61 and 31 advanced lung cancer patients treated with ICB were included in this study. Quantification of cfDNA concentration was performed before the start of the treatment and patients were followed up for a median of 34 (30–40) months. The prognostic predicted value of cfDNA was evaluated based on ROC, and Cox regression was conducted via univariate and multivariate analyses to estimate the hazard ratio. We observed that a cfDNA cut-off of 0.55 ng/µL before the ICB determines the overall survival of patients with a log rank p-value of 3.3 × 10−4. That represents median survivals of 3.8 vs. 17.5 months. Similar results were obtained in the validation cohort being the log rank p-value 3.8 × 10−2 with median survivals of 5.9 vs. 24.3. The univariate and multivariate analysis revealed that the cut-off of 0.55 ng/µL before ICB treatment was an independent predictive factor and was significantly associated with a better survival outcome. High cfDNA concentrations identify patients with advanced NSCLC who do not benefit from the ICB. The determination of cfDNA is a simple test that could select a group of patients in whom new therapeutic strategies are needed.
Bioinformatics Screen Reveals Gli-Mediated Hedgehog Signaling as an Associated Pathway to Poor Immune Infiltration of Dedifferentiated Liposarcoma
Authors: Beadle Erik P. , Bennett Natalie E. , Rhoades Julie A.
Published: June 2023

Liposarcomas are the most diagnosed soft tissue sarcoma, with most cases consisting of well-differentiated (WDLPS) or dedifferentiated (DDLPS) histological subtypes. While both tumor subtypes can have clinical recurrence due to incomplete resections, DDLPS often has worse prognosis due to a higher likelihood of metastasis compared to its well-differentiated counterpart. Unfortunately, targeted therapeutic interventions have lagged in sarcoma oncology, making the need for molecular targeted therapies a promising future area of research for this family of malignancies. In this work, previously published data were analyzed to identify differential pathways that may contribute to the dedifferentiation process in liposarcoma. Interestingly, Gli-mediated Hedgehog signaling appeared to be enriched in dedifferentiated adipose progenitor cells and DDLPS tumors, and coincidentally Gli1 is often co-amplified with MDM2 and CDK4, given its genomic proximity along chromosome 12q13-12q15. However, we find that Gli2, but not Gli1, is differentially expressed between WDLPS and DDLPS, with a noticeable co-expression signature between Gli2 and genes involved in ECM remodeling. Additionally, Gli2 co-expression had a noticeable transcriptional signature that could suggest Gli-mediated Hedgehog signaling as an associated pathway contributing to poor immune infiltration in these tumors.
Evaluation of Everyday Living Areas for Deinstitutionalized Community-Living People with Mental Illness
Authors: Nakai Yuri , Nakai Hisao
Published: June 2023

Deinstitutionalization of psychiatric care has been associated with increased homelessness, crime, and suicide, partly owing to insufficient, adequate, and accessible community resources. Therefore, appropriate resource placement is a key deinstitutionalization issue. The study’s aim was to identify residential group homes for people with mental illness in Kochi Prefecture, Japan, and the social resources necessary for social reintegration using a geographic information system (GIS). Everyday living areas (ELAs), as defined by the Japanese Community-Based Integrated Care System for People with Mental Illness (CICSM), were assessed using ELA location simulations. We used GIS to determine the spatial distribution of group homes, visiting nursing stations, psychiatric hospitals, daycare centers, and employment support offices. Following the CICSM definition of ELAs, we identified areas that people with mental illness could reach within 30 min on foot/by bicycle and counted the number of social resources in them. The ELA location simulation results suggest that policymakers should avoid uniform distribution of ELAs according to the CICSM definition. Establishing ELAs in suburban areas requires careful consideration of the available community resources, number of people with mental illness, existing support systems, and feasibility of the location.
Diagnostic Value of Serum Creatinine and Cystatin-C-Based Indices and Ishii Score in Cancer-Related Sarcopenia
Authors: Ding Liming , Wang Xingyu , Mao Tiantao , Li Jibin
Published: June 2023

Background: Sarcopenia is a key factor affecting the prognosis of cancer patients; however, identifying patients at risk remains challenging. The serum creatinine/cystatin C ratio (CCR) and the sarcopenia index (SI) are new biomarkers for sarcopenia screening. The Ishii test score is an equation based on age, grip strength, and calf circumference for sarcopenia screening. However, their performances in advanced cancer patients have not been thoroughly studied. We aimed to evaluate and compare the accuracy of three screening tools in diagnosing cancer-related sarcopenia. Methods: A total of 215 cancer patients with a median age of 60.5 y were enrolled in this cross-sectional study. The Asian Working Group for Sarcopenia 2019 (AWGS2019) criteria were used as a standard. The diagnostic accuracies of the CCR, SI, and Ishii screening test were analyzed in terms of sensitivity, specificity, negative and positive predictive values, the Youden index, and the receiver operating characteristic (ROC) curve. Results: According to the AWGS2019 criteria, the prevalence of sarcopenia and severe sarcopenia was 47.9% and 18.6%, respectively. The CCR, SI (positively), and Ishii scores (negatively) were correlated with muscle mass. Accordingly, sarcopenia was negatively correlated with CCR and SI, while it was significantly positively correlated with the Ishii score. In males, the AUCs of the CCR, SI, and Ishii scores were 0.743 (95%CI 0.65–0.836), 0.758 (95%CI 0.665–0.852), and 0.833 (95%CI 0.751–0.909), respectively. In females, the AUCs of the CCR, SI, and Ishii scores were 0.714 (95%CI 0.61–0.818), 0.737 (95%CI 0.635–0.839), and 0.849 (95%CI 0.775–0.932), respectively. The AUC of the Ishii score was significantly higher than that of the other screening tools (p < 0.001). The cut-off value of the optimal Ishii score was 102.3 (sensitivity: 93.2%, specificity: 59.1%) for males and 98.3 (sensitivity: 93.3%, specificity: 64.7%) for females. Conclusions: The CCR and SI based on serum CysC and creatinine had a remarkably similar overall diagnostic accuracy for sarcopenia in advanced cancer. Among the above three sarcopenia screening tools, the Ishii score chart seemed to have better predictive values of sarcopenia in cancer patients.
Systematic Analysis of Galactinol Synthase and Raffinose Synthase Gene Families in Potato and Their Expression Patterns in Development and Abiotic Stress Responses
Authors: Jing Quankai , Chen Airu , Lv Zhaoyan , Dong Zhihao , Wang Lixia , Meng Xiaoke , Feng Yue , Wan Yu , Su Chengyun , Cui Yanjie , Xu Wenjuan , Hou Hualan , Zhu Xiaobiao
Published: June 2023

Raffinose family oligosaccharides (RFOs) are very important for plant growth, development, and abiotic stress tolerance. Galactinol synthase (GolS) and raffinose synthase (RFS) are critical enzymes involved in RFO biosynthesis. However, the whole-genome identification and stress responses of their coding genes in potato remain unexplored. In this study, four StGolS and nine StRFS genes were identified and classified into three and five subgroups, respectively. Remarkably, a total of two StGolS and four StRFS genes in potato were identified to form collinear pairs with those in both Arabidopsis and tomato, respectively. Subsequent analysis revealed that StGolS4 exhibited significantly high expression levels in transport-related tissues, PEG-6000, and ABA treatments, with remarkable upregulation under salt stress. Additionally, StRFS5 showed similar responses to StGolS4, but StRFS4 and StRFS8 gene expression increased significantly under salt treatment and decreased in PEG-6000 and ABA treatments. Overall, these results lay a foundation for further research on the functional characteristics and molecular mechanisms of these two gene families in response to ABA, salt, and drought stresses, and provide a theoretical foundation and new gene resources for the abiotic-stress-tolerant breeding of potato.
Therapeutic Targeting of DNA Replication Stress in Cancer
Authors: Gu Long , Hickey Robert J. , Malkas Linda H.
Published: June 2023

This article reviews the currently used therapeutic strategies to target DNA replication stress for cancer treatment in the clinic, highlighting their effectiveness and limitations due to toxicity and drug resistance. Cancer cells experience enhanced spontaneous DNA damage due to compromised DNA replication machinery, elevated levels of reactive oxygen species, loss of tumor suppressor genes, and/or constitutive activation of oncogenes. Consequently, these cells are addicted to DNA damage response signaling pathways and repair machinery to maintain genome stability and support survival and proliferation. Chemotherapeutic drugs exploit this genetic instability by inducing additional DNA damage to overwhelm the repair system in cancer cells. However, the clinical use of DNA-damaging agents is limited by their toxicity and drug resistance often arises. To address these issues, the article discusses a potential strategy to target the cancer-associated isoform of proliferating cell nuclear antigen (caPCNA), which plays a central role in the DNA replication and damage response network. Small molecule and peptide agents that specifically target caPCNA can selectively target cancer cells without significant toxicity to normal cells or experimental animals.
Description of Neuropsychological Profile in Patients with 22q11 Syndrome
Authors: Lorena Joga-Elvira , Sandra Palma-Robleda
Published: June 2023

Background: 22q11 deletion syndrome (SD22Q11) is a neurogenetic condition that is associated with a high risk of neurodevelopmental disorders and intellectual disability. People with SD22Q11, both children and adults, often experience significant difficulties in social interactions, as well as neurocognitive deficits, and have elevated rates of autism spectrum disorder (ASD). Despite this, the relationship between basic cognitive processes and cognitive ability in this population has not been well investigated. Methods: the main objective of the present research is to describe the neurocognitive profile of people with SD22Q11 using standardized neuropsychological assessment instruments. For this purpose, a sample of 10 participants aged between 7 and 15 years was administered an assessment battery with the following tests: WISC-V, CELF-5, NEPSY-II, CSAT-R, CARAS-R, TP, MABC-2, BRIEF-2, SENA, DABAS, ABAS-II, SCQ, and ADOS-2. Results: the results showed IQ scores in the borderline normal range, as well as difficulties in language functions, social skills, motor skills, and executive functions. Conclusions: an individualized assessment taking into account the globality of its expression, and a therapeutic approach adapted to the specific needs of children with this syndrome is essential.
Correction: Jafari et al. Modeling Thermal Developmental Trajectories and Thermal Requirements of the Ladybird Stethorus gilvifrons. Insects 2023, 14, 11
Authors: Jafari Maryam , Goldasteh Shila , Aghdam Hossein Ranjbar , Zamani Abbas Ali , Soleyman-Nejadian Ebrahim , Schausberger Peter
Published: June 2023

Following the publication of [...]
A Joint De-Rain and De-Mist Network Based on the Atmospheric Scattering Model
Authors: Gu Linyun , Xu Huahu , Ma Xiaojin
Published: June 2023

Rain can have a detrimental effect on optical components, leading to the appearance of streaks and halos in images captured during rainy conditions. These visual distortions caused by rain and mist contribute significant noise information that can compromise image quality. In this paper, we propose a novel approach for simultaneously removing both streaks and halos from the image to produce clear results. First, based on the principle of atmospheric scattering, a rain and mist model is proposed to initially remove the streaks and halos from the image by reconstructing the image. The Deep Memory Block (DMB) selectively extracts the rain layer transfer spectrum and the mist layer transfer spectrum from the rainy image to separate these layers. Then, the Multi-scale Convolution Block (MCB) receives the reconstructed images and extracts both structural and detailed features to enhance the overall accuracy and robustness of the model. Ultimately, extensive results demonstrate that our proposed model JDDN (Joint De-rain and De-mist Network) outperforms current state-of-the-art deep learning methods on synthetic datasets as well as real-world datasets, with an average improvement of 0.29 dB on the heavy-rainy-image dataset.