bluuebunny/crossref_metadata_2025 huggingface dataset:
Inovasi Kreativitas Kepala Sekolah SMP Muhammadiyah 1 Surakarta untuk Menjadi Sekolah Unggul
Authors: Rochandhito Hidayah , Inayati Nurul Latifatul
Published: March 2024

The purpose of this research is to explore the leadership process of a school principal to increase the principal's creative innovation at SMP 1 Muhammadiyah Surakarta and the obstacles encountered in the practice of school innovation. This research is a field research (field research). The author uses a type of field research, namely a phenomenological qualitative approach using data collection methods, observation, interviews and documentation. The results of this study seek the integration of all activities so as to be able to produce synergies to achieve efficient, effective and objective school goals. There are many excellent programs provided by school principals through their innovations at SMP 1 Muhammadiyah Surakarta in the form of Tahfidzul Quran, Memorization of the Qur'an, Memorization of Tajwid, Shirohnabawiyah. In practice, there are obstacles that are made to answer innovation problems, the student factor is the limited facilities in schools that are incomplete and there is no support from the local community and parents to carry out school innovation practices and there are limited insights, and narrow mindsets and lack of qualifications are obstacles in the application of innovation parquetk applied by the school principal. The Principal has an important role as an innovator. There needs to be support from the Principal in making improvements, and education staff must support and provide guidance so that they can develop optimally in carrying out the tasks that are their respective burdens. What is meant by creative is that in improving the professionalism of an educator, the principal must look for new ideas and ways of doing his job.
Keefektifan Model Pembelajaran Student Teams Achievement Devision (STAD) Berbantuan Media Puzzle untuk Meningkatkan Pemahaman Konsep IPA pada Siswa Kelas 4 SD Negeri 1 Prigi
Authors: Arumsari Desy Retno , Suryani Ela
Published: March 2024

The purpose of this study was to determine the effectiveness of using the Student Teams Ahievement Division (STAD) learning model assisted by Puzzle media on understanding the concept of science in class IV students at SDN I Prigi. This study uses a quantitative approach with a research design that is a quasi-experimental design in the form of a non-equivalent control group design. Samples were taken by purposive sampling technique. SDN 1 Prigi as the experimental class and class IV SDN 3 Prigi as the control class. Data collection techniques using observation techniques, tests, and documentation. The data analysis technique used is the Normality Test, Homogeneity Test, Independent Sample T-Test, Simple Linear Regression Test, Paired Sample T-Test. The results of this study indicate: (1) There are differences in the student teams achievement division (STAD) learning model assisted by media puzzles in terms of understanding science concepts in experimental class students and the student teams achievement division (STAD) learning model without puzzle media, this is evidenced by a significant level 0.000 which is <0.05 using an independent sample t-test. (2) There is an influence of the student teams achievement division (STAD) learning model assisted by media puzzles on increasing students' understanding of science concepts, this is evidenced by a significant level of 0.002, which is <0.05 using a simple linear regression test. (3) The student teams achievement division (STAD) learning model assisted by puzzle media can improve students' understanding of science concepts, this is evidenced by a significant level of 0.000, which is <0.05 using a paired sample t-test. Based on this study it can be concluded that there are differences, influences, and increased understanding of the concept of science in the use of the student teams achievement division (STAD) model assisted by media puzzles for students at SDN 1 Prigi.
Pengembangan E-Modul Menggunakan Flipbook Maker Berbasis Metode Problem Solving untuk Meningkatkan Keterampilan Bernalar Kritis Siswa Kelas V Sekolah Dasar
Authors: Nadiman Nadiman , Purnamasari Iin , Sumarno Sumarno
Published: March 2024

This study aims to determine the feasibility, practicality, and effectiveness of e-module teaching materials using problem solving learning model-based flipbook makers. This research is research and development by adopting the Brog & Gall model (containing potential and problem analysis, product design, product assessment, product manufacture, product testing, and final product manufacture.). The analysis stage of potential problems includes carrying out initial observations during pre-research analyzing problems, media, teachers, and students. The product design stage includes instructions for use, table of contents, mapping of Basic Competency, glossary, indicators and learning objectives, benefits of e-modules, maps concepts, materials, summaries, exercises, worksheets, competency tests, answer keys and bibliography. The development stage is making e-module teaching materials with product aspects, material content, validation and display of the production of e-module teaching materials using a flipbook maker and also developing data instruments. The data collection instruments in this study were product feasibility from expert lecturers and education practitioners, practical worksheets for elementary school teachers and peers. For students readability sheets, pretest and posttest questions for the final evaluation of student learning after using the e-module. The data collection instrument was based on assessments by experts/lecturers, education practitioners, class teachers, peers and also students as research objects. The implementation stage of using the e-module has been developed for fifth grade students at SDN Karangasem 08 Batang. The trials carried out at this stage were product feasibility tests, product legibility and pretest posttest for students, with the results showing an increase in students' critical thinking after students used e-modules using flipbook makers. Evidenced by the paired t-test, the magnitude of the increase in the average pretest and posttest scores shows that there is an average increase (gain) in the pretest and posttest values obtained by 61.00 and 77.72 with an average difference of 16.72. The increase in average indicates that the E-module Flipbook based on the problem solving learning model is effectively used in social studies content in class V SDN Karangasem 08 Batang. The evaluation stage includes the form of evaluation carried out at each stage of the Borg and Gall model. The data analysis technique used is the manova and n-gain tests. The results show that the developed flipbook maker-based e-module is suitable for use in Civics learning. The e-module is feasible and practical to use, and effective for improving the critical thinking skills of fifth grade elementary school students.
THE IMAGE OF ANNA YAROSLAVNA IN FINE ARTS: PAST AND PRESENT
Authors: KONOVALOVA Olha
Published: March 2024

The article focuses on the iconography of Anna Yaroslavna (around 1032-between 1075 and 1089), the daughter of Yaroslav Mudry (983/98-1054), who was married to Henry I (1027-1060) and acquired the status of Queen of France. The study is based on the most famous portraits created by artists from the Middle Ages to the present day in various types of visual arts - sculpture, painting, graphics, numismatics. It is not known for certain what the princess looked like – rather insignificant evidence about her appearance has been preserved. In historical chronicles, the red hair color of the young wife of Henry I is primarily noted. More often, character traits are emphasized – kindness, generosity, humility, self-sacrifice. Portraits of the daughter of Yaroslav Mudry during his lifetime cause heated discussions in scientific circles. It is hypothesized that the sons and not daughters of Yaroslav the Wise are depicted in St. Sophia Cathedral (11th century). And on the copy of the 18th century from a drawing by the Dutch artist A. van Westerfeld in 1651, another couple is represented – Volodymyr Svyatoslavych and his wife Anna (baptizers of Rus) accompanied by eight princes and princesses. Engraved and sculptural portraits of the 17th century, despite the fashionable image of the era, reveal certain characteristic features of Anna Yaroslavna – thinness, general elegance, elongated face oval. Modern Ukrainian artists (V. Znoba, M. Znoba, G. Sevruk, V. Stelmakh), recreating the image of Anna Yaroslavna, are guided by the well-known engraved image of the Flemish artist Jacobus de Bie in 1643. At the same time, each portrait is distinguished by the author's decision and virtuoso mastery of the material. The presented article is not only the first intelligence covering pictorial and historical sources. The collected material testifies to the significant contribution of national history to the development of the European political and cultural space, is a demonstration of unity and friendly relations between Ukraine and France.
SEARCH FOR ARTISTIC SOLUTIONS IN THE EUROPEAN RENAISSANCE ENGRAVING
Authors: ZADNIPRYANY Gennady
Published: March 2024

The article examines the search for artistic solutions in the European engraving of the Renaissance. The technological, aesthetic and social reasons for the emergence of this new art form are considered. The difference between edge and incisal engraving techniques on wood and metal is highlighted. The main features and mannerisms of famous masters of various national schools of reproduction, creative and book engraving are described. Engraving on the territory of Europe arose at the turn of the 14th and 15th centuries. It had its own technological prototypes that existed before. For xylography, these are stamps-seals and punches, for engraving - the craft of jewelers, for etching – the skill of gunsmiths. But, like a print on paper of an image cut on a special board or etched on a metal plate, it appears only in our time. This coincided with the collapse of the medieval highly synthetic type of art, the growing desire for a more visually accurate depiction of nature, interest in a scientific perspective, secular themes. Unlike painting, engraving took on the qualities of symbolism and abstraction. In addition, engraving differs from other types of fine art by a special quality – circulation. In the second half of the 15th century, books appeared with illustrations showing various tools or the structure of the Solar System, the specifics of certain plants, and city views. The circulation of the engraving contributed to the rapid and convenient distribution of the nobility. This continued until the middle of the 19th century, when photography and photomechanics appeared, which in many ways replaced engraving [4]. But until that moment, thanks to its ability to reproduce, engraving itself can be considered one of the tools for expanding knowledge. Today, in the era of digital technologies, interest in traditional engraving techniques does not disappear. Studying and rethinking the achievements of previous periods makes it possible to expand the expressive means of artistic works.
FEATURES, PROBLEMS, AND PROSPECTS OF USING ARTIFICIAL INTELLIGENCE IN THE CONTEMPORARY ART FIELD: WRITING, FINE ARTS, VOICE ACTING
Authors: TSYSARSKYI Volodymyr
Published: March 2024

This article describes most things related to the rapidly developing Artificial Intelligence which use Neural networks to create all sorts of stunning things. The article covers what exactly Artificial Intelligence is, its short history of development and some techniques it uses. Next comes AI-image generation, which is quite popular right now as it opens possibilities that artist have dreamt for a long time. In the world of fine arts, AI algorithms inspire artists by offering fresh perspectives, styles, and techniques. Here the main advantages of using such AI is described, why it suddenly become popular, roughly explained about its algorithm of work, how users can actually use it and named the most popular tools. Also there described weaknesses of such image generators such as actually low understanding of word-object relationship, it is hard for it to grasp abstract things such as figurative meanings and hard to control what author exactly want to generate. The article also describes usage of Neural Networks in writing field. In the realm of writing, AI-powered tools assist in crafting plots, developing characters, and even producing complete articles or stories. There it can be used both as a helper tool to find proper wording or improve writing style, as well as writing complete stories or at least helping writers to outline the first draft. It can also present advanced writing techniques in easily editable visual form by using experimental TaleBrush, which can greatly help beginners in writing field but also professionals. Not just that, but creating believable characters using Chat bots or enhancing language translation. AI can revolutionize voice acting by providing realistic and diverse AI-generated voices, opening up new possibilities for character creation. Voice acting is another field that would greatly benefit from using AI, as it allows to basically create entire songs and albums just using Vocaloids, do voiceovers for films and games with VoiceVox and create and edit podcasts with fast-learning AI text to speech synthesizers. In conclusion the future of AI tools were described such as advanced video editing, help with programming and possibility to create an entirely generated and live imaginary world in games with lively NPC which previously was just impossible.
Innovative Frontiers: Advancing Technologies for Pesticide Elimination in Grape Seeds
Authors: Tırpancı Sivri Göksel
Published: March 2024

Grape seeds, a valuable by-product of winemaking, are rich in bioactive compounds with significant economic potential. However, pesticide residues in grape seeds pose risks to human health and product quality. This study explores innovative technologies including cold plasma, ultrasound, aqueous ozone, and gaseous ozone to eliminate pesticide residues from grape seeds. Cold plasma treatment emerged as highly effective, completely eliminating certain pesticides like Triadimenol and Azoxystrobin. Ultrasound treatment also showed promising results, particularly in reducing Pyrimethanil residues. Aqueous ozone treatment achieved moderate reductions, while gaseous ozone exhibited the least efficacy. Factors influencing efficacy included pesticide type, treatment duration, and matrix characteristics. Future research should focus on optimizing parameters to enhance pesticide removal while minimizing impacts on product quality. These findings underscore the importance of tailored approaches for pesticide elimination, contributing to safer agricultural practices and consumer health
Introduction to Documentation Studies
Authors: Lund Niels Windfeld
Published: March 2024

This book presents the first comprehensive introduction to documentation studies. It outlines the historical background of, and the theoretical foundation for a complementary approach to documentation issues and processes: not only in the context of academic study, but also in the practice of documentation in different parts of society.

What do a composer, a writer, a painter, a historian, a political activist, and a social agency office have in common? They all create documents to communicate and inform the world, making documentation a necessity for any human interaction in society. Through six case-studies, the book shows how a complementary analysis of the intertwined processes of documentation, communication, and information in any kind of human interaction can be conducted. It demonstrates the relationships between the agents involved, the means chosen and in which modes the resulting complexes of documents are created, regardless of the field.

The complementary analytical model and method is relevant not only for documentation, communication, and information scholars, but to a range of fields of research in humanities, social sciences and natural sciences/engineering and design.

Written by an expert in documentation, this book provides a solid theoretical and analytical framework for professionals in archives, libraries, and museums, and for all those who manage documents as part of their professional life in healthcare, transportation, education, production and trade.
Instagram Live Sebagai Salah Satu Wahana Dalam Edukasi Kesehatan Telinga dan Pendengaran
Authors: Arie Yuliyani Eka , Kadriyan Hamsu , Yudhanto Didit , Ayu Trisna Aryani Gusti , Rahayu Rarasati Rista , Agung Ayu Niti Wedayani Anak , Triani Eva
Published: March 2024

Menjaga kesehatan telinga dan pendengaran merupakan dua hal yang harus dilakukan dan memerlukan perhatian khusus, karena keduanya dapat mempengaruhi kualitas hidup seseorang. Dengan peringatan hari pendengaran sedunia, Dokter Spesialis THT yang tergabung dalam PERHATI-KL Cab. NTB kembali melakukan penyuluhan kesehatan terkait kesehatan telinga dan pendengaran mengingat angka kesakitan yang relatif tinggi di masyarakat. Edukasi kesehatan ini dilakukan melalui media live Instagram dimana masyarakat dapat mengikuti edukasi secara langsung dan dapat bertanya melalui fitur chat yang disediakan dan dijawab langsung oleh narasumber. Media Instagram menempati posisi ke-4 dari 10 media sosial yang paling banyak digunakan di Indonesia setelah Youtube, WhatsApp dan Facebook, khususnya oleh kalangan remaja. Melalui media live Instagram ini diharapkan informasi kesehatan yang disampaikan dapat diterima dengan baik dan mudah oleh masyarakat sehingga dapat diterapkan dalam kehidupan sehari-hari. Alhasil, kegiatan ini disaksikan oleh sekitar 50-60 orang yang menunjukkan antusiasme yang tinggi dari masyarakat dan menjadi bahan evaluasi pelaksanaan kegiatan pendidikan selanjutnya.
Diarreia Crónica como Apresentação de Infeção por VIH: Um Relato de Caso
Authors: Gonçalves Luís Joana , Maria Araújo Rosa , Martins Bárbara , Mendes Ângela , Cardoso Ramos Filipa
Published: March 2024

Define-se diarreia crónica predominantemente pela diminuição da consistência das fezes com duração superior a quatro semanas. O diagnóstico diferencial é vasto, incluindo patologias diversas tais como doença celíaca, disfunção tiroideia, doença inflamatória ou neoplásica intestinal, síndrome do intestino irritável, infeções crónicas e imunossupressão. O vírus da imunodeficiência humana (VIH) associa-se comummente a diarreia, tanto na sua apresentação aguda como no decorrer da evolução da doença, devendo ser considerado no diagnóstico diferencial desta entidade clínica. Reporta-se o caso de um indivíduo do sexo masculino com 59 anos, cujo diagnóstico da infeção por VIH decorreu na sequência da investigação etiológica de uma diarreia crónica nos cuidados de saúde primários. O médico de família deve ter um elevado grau de suspeição nestes casos independentemente da ausência aparente de comportamentos de risco para infeção por VIH.
Petrópolis: a parcialidade do direito à paisagem urbana-cultural. Discussões perante os impactos das chuvas de 2022
Authors: Hiratuka Kai Haru Rosandiski , Ferreira Jane Victal
Published: March 2024

A cidade de Petrópolis tem sua formação vinculada às atividades que amparam a Corrida do Ouro no Brasil durante o século XVIII, sobretudo a partir da abertura do Caminho Novo da Estrada Real. A fundaç
Avaliação da performance dos sites de portal de notícia, comércio eletrônico e universidade pública federal com base nos princípios da Interação Humano-computador.
Authors: Silva Francyane Reis da , Silva Reinaldo de Jesus da , Fonseca Luís Carlos Costa
Published: March 2024

Este artigo propõe uma investigação minuciosa da performance dos renomados sites portal de notícia, e-commerce e universidade pública federal, através da lente dos pressupostos essenciais da Interação Humano-Computador (IHC). O foco da avaliação incidirá sobre os seguintes aspectos: Usabilidade, Acessibilidade e Segurança de dados dos Usuários, além da aplicabilidade de Técnicas de IHC. A validação de acessibilidade e desempenho será conduzida mediante o uso de software livre. Ao final, serão apresentadas conclusões detalhadas sobre os resultados obtidos, destacando os pontos fortes e as áreas que requerem melhorias em cada um dos sites analisados.
MODELAGEM PARA PREVISÃO DE ÁREA EFETIVA E COBERTURA DE WI-FI EM PÁTIOS DE CARRETAS NO PORTO DO ITAQUI
Authors: Torres Caio de Castro , Amaral Henrique Mariano Costa do
Published: March 2024

O Porto do Itaqui é um dos principais portos do Brasil no Atlântico Norte, possui oito berços operacionais com profundidades que variam de 12 a 19 metros, permitindo a atracação de navios de grande porte [1]. No ano de 2023, o porto do Itaqui movimentou 36,419 milhões de toneladas divididas entre cargas gerais e os granéis líquidos e sólidos [2]. Dessa forma, observa-se a importância dos caminhões e carretas que fazem a carga e descarga de navios. Com o aumento ano após ano da movimentação no Porto do Itaqui, aumentou também o contingente para suprir a carga e descarga, sendo necessários mais carretas para o serviço. A carga e descarga são feitas de forma efetivas e respeitando a segurança, entretanto por conta da alta demanda, os caminhoneiros têm que ficar aguardando a sua vez de ser atendido, dessa forma, eles precisam ficar esperando em pátios. Esse artigo tem o objetivo de estimar esse crescimento e com isso, fornecer consultoria para as empresas que prestam o serviço de pátio, para que elas saibam o quanto devem aumentar gradativamente a área efetiva e também como ter uma cobertura de Wi-Fi na região, já que é uma área afastada da capital e não é totalmente coberta pelas redes móveis disponíveis na ilha de São Luís, e é preciso para que os caminhoneiros possam acessar informações sobre a movimentação portuária e saibam se é o momento de irem ao porto ou não, além de não ficarem desconectados, algo que, hoje, não estamos mais habituados. Atualmente, muitos motoristas que aguardam a sua vez de carregar ou descarregar ficam desconectados da internet. Isso pode causar transtornos, pois os motoristas podem perder oportunidades de negócios ou ficar sem informações sobre a movimentação portuária. Para estimar o crescimento da frota de caminhões e carretas no Porto do Itaqui, foi feito uma modelagem utilizando dados históricos de movimentação portuária, o que mostrou o aumento da demanda dos caminhoneiros e foi feito uma pesquisa de satisfação e o ponto principal de reclamação dos mesmos, foi a respeito da internet, mostrando a importância que esse levantamento pode trazer de benefícios para os empresários do ramo, pois conseguirão se destacar em relação ao concorrente por prestar um serviço de qualidade e confiabilidade.
A utilização de programação no-code para criação de aplicativos
Authors: Pereira Daniel Gusmão , Amaral Henrique Mariano Costa do
Published: March 2024

O projeto diz respeito a um aplicativo implementado com a utilização de uma plataforma No-Code a ser usado na igreja Assembleia de Deus - Congregação Gileade, sendo uma solução que permite a aplicação na prática de conceitos relacionados à programação sem código, sendo uma solução mobile, ou com utilização de um programa a ser executado tanto em sistemas Android, quanto em sistemas iOS. Este artigo apresenta além do aplicativo os conceitos relacionados não somente à codificação sem código, mas também com pouco código. E a necessidade de implantação desse aplicativo, se justifica ao se perceber a necessidade de programação de sistemas, com mais agilidade e que pudesse estar ao alcance de seus usuários, principalmente daqueles com pouco ou nenhum conhecimento em linguagem de programação. O conceito foi comprovado mostrando que a solução foi realizada com mais agilidade e rapidez, do que se fosse realizada por um ambiente de desenvolvimento integrado (IDE) ou Framework de sistema operacional Android, como é o caso do: Android Studio e Flutter. O aspecto de programação sem código foi justificado pelo crescimento muito rápido desse tipo de implementação e pela necessidade de maior celeridade na criação de sistemas mobiles.
Otimização de Conjuntos de Imagens Médicas Usando a Combinação de Transformada Wavelet e Interpolação
Authors: Arruda Luciano S. de , Amaral Henrique M. C. do , Fonseca Luis C. C.
Published: March 2024

A técnica proposta foi aplicada a um conjunto de dados público de imagens de pneumonia disponibilizado na plataforma Kaggle. A ideia é reduzir o tamanho espacial do conjunto de dados, mantendo a qualidade das imagens intacta, para melhorar a eficiência em termos de armazenamento e processamento. A técnica utiliza a transformada wavelet para minimizar a redundância espacial das imagens e a interpolação para criar novos pixels a partir dos existentes. Os resultados mostram que a abordagem foi bem-sucedida, com uma redução significativa no tamanho do conjunto de dados sem afetar a precisão da classificação pela rede neural treinada com as imagens comprimidas.
A representação social da covid-19 veiculada pelo jornal O Globo durante a pandemia
Authors: Oliveira Denize Cristina de , Castro Suzana da Silva , Machado Yndira Yta , Domingues Juliana Pereira , Silva Keila Pereira da
Published: March 2024

O estudo em que se baseia este artigo objetivou discutir os conteúdos representacionais da covid-19 veiculados pelo jornal O Globo. Trata-se de uma pesquisa documental, descritiva, pautada na teoria das representações sociais. Foram coletadas matérias jornalísticas publicadas no período de 11 de março de 2020 a 30 de junho de 2021. Ao todo, 421 matérias foram analisadas com o software de análise lexical Iramuteq. Os resultados mostram seis classes lexicais, discutidas a partir de três contextos organizadores da representação social da covid-19: as dimensões sociais e econômicas da doença; os fatores constituintes do seu enfrentamento, e a política e seus representantes na pandemia. Concluiu-se que foi possível observar o uso de formas subliminares de veiculação de uma visão neoliberal e biomédica durante a pandemia, obscurecendo o papel do Estado na redução das vulnerabilidades sociais, assim como a atuação do campo da Saúde Pública.
Development and validation of a method for the quantitative determination of monoamine neurotransmitters and their metabolites in rat brain tissue using HPLC-MS/MS
Authors: Khokhlov A. L. , Yaichkov I. I. , Korsakov M. K. , Kagramanyan I. N. , Volkhin N. N. , Petukhov S. S. , Zaikova V. E.
Published: March 2024

Background. Determining changes in the content of monoamine neurotransmitters and their metabolites in brain structures is a necessary part of studying the pharmacodynamics of  antiparkinsonian drugs. A  method for  the  joint determination of norepinephrine, adrenaline, dopamine, serotonin, 5-hydroxyindole-3-acetic acid, 3,4-dihydroxyphenylacetic acid, homovanillic acid, vanillylmandelic acid in rat brain tissue has not previously been developed.

The aim of the study. To develop and to validate a method for the quantitative determination of norepinephrine, adrenaline, dopamine, serotonin, 5-hydroxyindole3-acetic acid, 3,4-dihydroxyphenylacetic acid, homovanillic acid, vanillylmandelic acid in rat brain tissue using high-performance liquid chromatography in combination with tandem mass spectrometry (HPLC-MS/MS).

Materials and  methods. A method for  determining monoamine mediators and their metabolites was developed using the HPLC-MS/MS method. Brain tissue homogenates were prepared using a  mechanical hand-operated homogenizer. The  effect of  various antioxidants on  the  stability of  norepinephrine, adrenaline, dopamine and 3,4-dihydroxyphenylacetic acid in the test samples was studied.

Results. Chromatographic separation of sample components was carried out using two Synergi Max RP (20 × 2.0 mm, 2.5 µm) and Synergi Fusion RP 80Å (250 × 4.6 mm, 4 µm) chromatographic columns. Elution was carried out in a gradient mode using a  mobile phase based on  methanol and  a  0.1% solution of  formic acid in  water. To prepare homogenate batches, the samples were diluted with a solution of internal standards in methanol. A 5% aqueous solution of ascorbic acid was chosen as an antioxidant stabilizer.

Conclusion. The  developed methodology has been fully validated and meets the requirements of Russian and international guidelines. The chosen stabilization method allows samples of brain homogenates to be stored for 30 days after collection.
Studies of the effect of indole and its derivative 1-benzylindole on the functional state of the heart and blood values of laboratory rats
Authors: Gorokhova L. G. , Mikhailova N. N. , Zhukova A. G. , Kazitskaya A. S.
Published: March 2024

Background. Indole and its derivatives are widely used in all areas of pharmaceutical production. The toxicometry of indole compounds has been sufficiently studied. At the same time, there is still no information on the toxic effect on individual organs and systems during long-term intake of most compounds.

The aim. To carry out an experimental study of the toxic effect of indole and its derivative 1-benzylindole on the functional state of the heart and blood values.

Materials and  methods. The  work was  carried  out on  46  white rats, divided into groups: control group (n = 22); animals receiving indole once a day for 1 month (n = 12); animals receiving 1-benzylindole once a day for 1 month (n = 12). The substances were administered intragastrically 5 days a week. The condition of the animals was assessed by integral parameters, peripheral blood parameters and biochemical serum tests, and morphological data.

Results. Administration of indole and 1-benzylindole caused an increase in the electrical activity of the atria, a decrease in the duration of the QRS complex, and a statistically significant decrease in  blood pressure and  body temperature compared to the control group. The intake of indole and 1-benzylindole decreased the number of red blood cells and hemoglobin, increased the activity of aspartate aminotransferase and alanine aminotransferase, and increased the concentrations of urea, total cholesterol and triglycerides in the blood. Against the background of long-term exposure to indole and 1-benzylindole, dystrophic disorders, hypertrophic and atrophic changes in individual fibers with a pronounced congestion of the microcirculatory vessels were revealed in the heart of rats.

Conclusion. Indole and 1-benzylindole in case of long-term intake lead to functional disorders of the cardiovascular system, which cause the development of arterial hypertension, coronary heart disease, and atherosclerotic vascular lesions. Preventive measures in industries with possible contact with indole and its derivatives should include regular medical examinations of workers with mandatory monitoring of electrocardiography and advanced indicators of general and biochemical blood tests.
Features of neurovegetative and humoral regulation of cognitive activity in adolescents when using electronic devices
Authors: Adamovskaya O. N. , Ermakova I. V. , Dogadkina S. B.
Published: March 2024

Background. Studying the functional state of the body of adolescents when they preform cognitive activity using electronic devices is of great importance due to the introduction of information and computer technologies into the educational process. Identifying the characteristics of the reactivity of students’ bodies when performing cognitive activities in  a  digital environment will contribute to  both optimization of learning and health protection.

The aim. To study the autonomic regulation of heart rate, electrodermal activity, cerebral circulation and the level of cortisol in saliva when adolescents performed a cognitive test on electronic devices (tablet, laptop) and on paper.

Materials and  methods. Using analysis of heart rate variability, electrodermal activity, rheoencephalography and enzyme-linked immunosorbent determination of cortisol in saliva, цe examined 48 adolescents while performing a cognitive activity on electronic devices.

Results. When adolescents perform cognitive activity using electronic devices, we can register changes in heart rate variability, electrodermal activity and cerebral circulation. Cognitive activity in a digital environment causes an increase in sympathetic effect ontheheart rate with adecrease inparasympathetic activity, anincrease inthe integrative indicator ofgalvanic skin response, invascular tone and adecrease in the cerebral blood flow intensity. One in four adolescents experiences anticipatory stimulation of the endocrine system before taking a cognitive test. Correlation analysis revealed alarge number of correlations between the studied indicators both in the initial state and during cognitive activity.

Conclusion. A large number of correlations, both in the initial state and during the cognitive test, between heart rate variability and cortisol concentration, cerebral circulation parameters indicate the preservation of a rigid system of neurovegetative and humoral regulation of heart rate when using electronic devices compared to paper-based media.
Evaluation of Medicago sativa ethanol leaf extract for antidiarrheal activity in Wistar rats
Authors: Anele Donatus Onyebuchi  , Akuodor Godwin Christian  , Okoroama Casmir Emeka  , Unaeze Bright Chukwuebuka  , Ajegi Innocent Fountain  , Iganga Ogbonnaya Nnabuike  , Nwokike Matthew Onyemaechi
Published: March 2024

Aim: Medicago sativa leaf is traditionally used for the treatment of gastrointestinal disorders in Nigeria. This research investigates the in vivo antidiarrheal activity of M. sativa (Alfalfa) leaf extract in Wistar rats. Method: The study employed three models: castor oil-induced diarrhea, gastrointestinal motility (charcoal meal), and castor oil-induced intestinal fluid accumulation. The phytochemical analysis as well acute toxicity tests were carried out in the leaf extract. Results: The results demonstrate a dose-dependent and significant antidiarrheal effect of M. sativa leaf extract. In the castor oil-induced diarrhea model, the extract reduced fecal frequency, delayed onset, and lowered severity, with the highest effect at 600 mg/kg compared to a positive control (Loperamide). Gastrointestinal motility was inhibited by the extract in a dose-dependent manner, achieving maximum effect at 600 mg/kg, comparable to atropine sulfate. The castor oil-induced intestinal fluid accumulation model revealed a significant decrease in fluid volume at 600 mg/kg, exhibiting a potent inhibitory effect. The oral LD50 values obtained were greater than 5000 mg/kg in rats Conclusion: This study provides compelling evidence of Medicago sativa leaf extract's potential as an antidiarrheal agent in Wistar rats. Further investigations could explore its mechanism of action and safety profile, contributing valuable insights to the development of novel antidiarrheal therapies.
Exploring through Freudian’s psychoanalysis, the impact of ID, Ego, and Superego on Amir’s transformation in the novel the kite runner
Authors: Najia Almas  , Urooj Fatima Fida Hussain  , Rameen Arif  , Nabiha Asif  , Aina Waris  , Sana Hadi  , Syeda Amna  , Sharifa Muhammad Nabi
Published: March 2024

This research work provides an in-depth psychoanalytic investigation of Amir’s character in the novel, The Kite Runner by Khalid Hosseini through the lens of Sigmund Freud’s tripartite model of personality structure. It delves deeply into the analysis of how Amir's character undergoes changes and adapts to various life situation by delving into his instinctive desire, intellectual decision making, as well as internal sense of morality. The study emphasizes how Amir’s actions, choices, and emotions are influenced by the three elements found in Sigmund Freud’s theory. This would furthermore, would shed light on Amir’s ongoing struggle regarding his quest for immediate pleasure, rationality, and ethical standards. Thus, this research exhibits an in-depth exploration of the protagonist's psychological journey and the themes of redemption, guilt, and self-discovery.
The effects of processing on cyanide and mineral contents of Garri from different sources
Authors: Ubong Edet Akpan  , Nyakno Akpan Essien  , Samuel Imeh Bassey  , Gideon Bassey Agbor  , Chisom Vivian Obinweaku  , Wisdom Edet Akpan  , Ekpenyong Enebiene Enebiene
Published: March 2024

In this study, garri from different sources were analysed in order to investigate the effects of processing on cyanide and mineral contents in the test samples using AOAC (2006). Cyanide and mineral analysis carried out on the test sample revealed the presence of cyanide and minerals in both yellow and white garri but in varying amounts. The level of cyanide in the yellow garri was 1.19 + 0.01a (Obubra), 1.16 + 0.02a (Yakurr), 1.08 + 0.02b (Bekwarra) compared to the white variety which was 1.24 + 0.02a (Obubra), 1.21 + 0.01b (Yakurr), 107.12 + 0.02c (Bekwarra) compared to the white garri 128.15 + 0.05a (Obubra), 124.2 + 0.1b (Yakurr), 114.5 + 0.2c (Bekwarra). Sodium in yellow garri was 3.27 + 0.25a (Obubra), 3.7 + 0.10a (Yakurr), 2.47 + 0.25b (Bekwarra), for white garri was 4.05 + 0.05a (Obubra), 4.6 + 0.10b (Yakurr), 3.08 + 0.02c (Bekwarra). Calcium in yellow garri was 9.6 + 0.10a (Obubra), 7.53 + 0.03b (Yakurr), 8.43 + 0.02c while in white garri was 12.117 + 0.08a (Obubra), 11.597 + 0.03b (Yakurr), 10.24 + 0.02c (Bekwarra). Magnesium in yellow garri was 12.3 + 0.25a (Obubra), 13.02 + 0.02b (Yakurr), 12.72 + 0.03a while in white garri was 14.6 + 0.10a (Obubra), 15.397 + 0.03b (Yakurr), 16.01 + 0.01c (Bekwarra). Iron in yellow garri was 0.02 + 0.01a (Obubra), 0.03 + 0.01b (Yakurr), 0.02 + 0.01b while in white garri was 0.05 + 0.01a (Obubra), 0.06 + 0.01b (Yakurr), 0.033 + 0.02c (Bekwarra). Zinc in yellow garri was 0.13 + 0.01a (Obubra), 0.15 + 0.02a (Yakurr), 0.14 + 0.02a (Bekwarra) while in white garri was 0.16 + 0.02a (Obubra), 0.22 + 0.02b (Yakurr), 0.18 + 0.02c (Bekwarra). Copper in yellow garri was 0.02 + 0.01a (Obubra), 0.013 + 0.01a (Yakurr), 0.027 + 0.01a (Bekwarra) while in white garri was 0.03 + 0.01a (Obubra), 0.02 + 0.01a (Yakurr), 0.033 + 0.02a (Bekwarra). Phosphorus in yellow garri was 23.04 + 0.04a (Obubra), 21.5 + 0.10b (Yakurr), 22.27 + 0.02c (Bekwarra) while in white garri was 26.2 + 0.10a (Obubra), 23.827 + 0.03b (Yakurr), 24.68 + 0.02c (Bekwarra). From the result of the study, yellow colour garri contains less amount of cyanide compared to white colour garri, it could be recommended that yellow colour garri is good for consumption. Also, considering minerals, white colour garri contained the highest amount of minerals which helps in proper functioning of the body and help in body build-up, it could be inferred that moderate consumption of white colour garri could be a source of mineral supplement.
Invitro and Invivo anti-inflammatory activity of Tabebuia pallida leaves
Authors: Radhika Batchu  , Mohan Gugulothu  , Venkat Ramana Mudari  , Samatha Enugurthi  , Pranathi Gouribhatla
Published: March 2024

As any change in the body like injury or destruction and inflammation is characterized by the changes in the body evaluation like heat, discomfort, swelling, redness and some physiological changes in the processes. The inflammatory process is a complicated series of relationship among substances and some elements that included in the connective tissue. An inflammatory response is the primary cause for wide range of disorders like allergies, metabolic syndromes, cancer and syndromic disorders etc., Immune related disorder plays as financial burden on individuals, in such conditions some drugs and medicines are used like steroids, nonsteroids and immunosuppressants which are some common medications for controlling the inflammatory response in the body. Most of these medications have side effects on the body like allergies and gastric ulcers. In such conditions they find the natural goods like plants having historically an excellent medication activity for inflammatory illnesses. But there is no specific information on the inflammatory activity reports used in literature. Scientists need to find new process with low cost, straightforward to invitro methodologies and to access the natural anti-inflammatory activity and focus on the anti-inflammatory methodology which can evaluate the natural anti-inflammatory substances. These are cost effective and easy to operate with minor alternatives. The activity is performed on egg albumin to know about its anti-inflammatory properties.
Analisis Kesiapan Belajar Siswa dalam Mengikuti Kegiatan Belajar Mengajar Berdasarkan Pembelajaran Berdiferensiasi
Authors: Amalia Fajrin Nida , Nugraheni Nursiwi
Published: March 2024

Penelitian ini dilakukan bertujuan untuk memperoleh gambaran mengenai kesiapan belajar peserta didik kelas III SD Negeri Pesantren. Hasil yang diperoleh berdasarkan penelitian ini digunakan untuk menentukan aspek strategi pembelajaran berdiferensiasi yang tepat, agar dapat digunakan secara menyeluruh dalam muatan pembelajaran. Penelitian yang dilakukan menggunakan metode desktriptis kualitatif, dengan teknik pengumpulan data berupa angket, wawancara, dan observasi bersama guru kelas. Pada riset ini peneliti memakai subjek penelitian sebanyak 29 peserta didik kelas III SDN Pesantren. Perolehan hasil dari riset ini menunjukkan bahwa kesiapan belajar merupakan keadaan individu yang menyeluruh sehingga seseorang siap untuk memberikan tanggapan ataupun jawaban dalam situasi tertentu dalam  hal ini adalah kesiapan belajar. Pada riset ini terbukti bahwa kesiapan belajar peserta didik menunjukkan 71,4% yang termasuk dalam kriteria tinggi, hasil kesiapan belajar tersebut dijadikan landasan dalam menerapkan strategi pembelajaran berdiferensiasi dengan memperhatikan 4 aspek berdiferensiasi. Implementasi yang mengarah pada tercapainya tujuan pembelajaran.
Peningkatan Kompetensi Pedagogik Guru Sekolah Dasar Islam Annajah Pebayuran Bekasi dalam Menyusun Soal Berbasis HOTS melalui Kegiatan BIMTEK
Authors: Munfaati Munfaati , Robandi Babang
Published: March 2024

Pembuatan soal yang baik dan benar menjadi syarat pokok dalam menunjang kompetensi profesional pedagogik seorang pendidik. Kegiatan BIMTEK ini bertujuan untuk meningkatkan keterampilan para pendidik di SD Islam Annajah Pebayuran Bekasi terkait dengan teknik penyusunan soal yang berbasis Hight Order Thinking Skill (HOTS). Kegiatan ini didasari oleh masih rendahnya kompetensi pendidik dalam menyusun soal berkategori HOTS. Kagiatan ini dilaksanakan pada Senin 07 November 2022 yang bertempat di aula Pesantren Islam Hidayatunnajah Bekasi. Metode penelitian ini menggunakan kaji tindak partisipatif. Metode ini merupakan keikutsertaan seseorang dalam melaksanakan sesuatu atau pengambilan bagian dari sesuatu yang harus dilaksanakan oleh pelakunya. Jadi, peneliti dalam BIMTEK ini terlibat secara aktif dalam kegiatan penyusunan soal berbasis HOTS. Hasil dari aktivitas BIMTEK ini dapat menambah wawasan dan kompetensi para pendidik dalam menyusun soal berbasis HOTS dengan mengembangkan materi dari Kompentensi Dasar, merumuskan indikator sesuai dengan level kognitif, dan menulis butir soal yang tepat sesuai dengan indikator soal.
Pengembangan Nilai-Nilai Religius Siswa melalui Kegiatan Pesantren Kilat di Sekolah Dasar
Authors: Muthmainnah Anti , Aljamaliah Syifa Nailul Muna
Published: March 2024

Artikel ini bertujuan untuk menguraikan pengembangan nilai-nilai religius siswa melalui kegiatan pesantren kilat. Fokus kajian ini melingkupi pengembangan nilai-nilai religius siswa mengungkapkan faktor pendukung dan penghambat penanaman nilai-nilai religius siswa di SDN 1 Cililin. Penelitian ini dilatarbelakangi oleh kemorosotan moral yang terjadi kalangan siswa sekolah dasar. Data yang diambil dalam artikel ini berasal dari kajian pustaka, wawancara, observasi di SDN 1 Cililin. Subjek penelitiannya adalah kepala sekolah, guru, serta siswa. Hasil dari penelitian ini menunjukkan berbagai kegiatan sholat dhuha, tadarus, ceramah, penampilan video atau film kisah nabi, dan kuis dapat mengembangkan nilai-nilai religius siswa. Penelitian ini juga menunjukka adanya faktor yang menjadi pendukung dan penghambat dalam pengembangan nilai-nilai religius siswa.
Investigation of the Protective Effects of Black Garlic Extract an Experimental Gastric Ulcer Model in Rats
Authors: Aktaş Serdar
Published: March 2024

This study aimed to evaluate the effects of black garlic extract in preventing gastric ulcers. For this purpose, twenty-eight 2-3 month-old Spraque dawley rats were randomly divided into four groups: the Control group (CG), Ulcer group (UG), Ulcer + pantoprazole treatment group (PTG), and Ulcer + Black garlic group (BGG). Stomach ulcers were induced by administering indomethacin at a dose of 25 mg.kg-1 to all groups except the control group. Then, pantoprazole (20 mg.kg-1) and black garlic extract (275 mg. rat) were administered to the treatment groups. After the study, stomach samples were collected and macroscopic (ulcer scoring and ulcerative area mm2) and histopathology examination (HE) were performed. In biochemical analysis, MDA (pg.ml-1), SOD (ng.ml-1) and CAT (ng.ml-1) levels were determined in the tissue. According to the macroscopic results obtained; Statistically significant changes were found between BGG and UG (p<0.0001). PTG showed better effects than all groups. In histopathology; no lesion was found on CG. There was a similarity between PTG and CG. While there were intense bleeding and ulcer foci in UG, only limited focal ulcers were found in BGG. MDA, the highest values were seen in UG. There was no statistical significance between PTG and BCG. The lowest SOD activity was in UG, and there was a similarity in PTG and BGG. The highest CAT activity was determined in CG and the lowest in UG. In conclusion; black garlic extract applied in a single and high dose (5% w.v-1, 275 mg. rat) showed partial protective activity against stomach ulcers.
Peranan Pemberian Stem Cells terhadap Percepatan Regenerasi Tulang pada Fraktur Mandibula: Rapid Review
Authors: Saefulhadi Arum Almalivia , Sjamsudin Endang , Suhardjo Suhardjo , Sudarmono Sudarmono
Published: March 2024

Pendahuluan: Fraktur mandibula merupakan fraktur pada tulang wajah yang paling sering terjadi. Fraktur ini dapat terjadi akibat kecelakaan lalu lintas, olah raga, bermain, perkelahian, kegiatan profesi ,atau bahkan saat latihan peperangan. Berbagai metode perawatan telah dilakukan untuk mempercepat penyembuhan fraktur mandibula. Pemberian stem cells saat iniÂ  merupakan salah satu alternatif perawatan pada fraktur karena stem cells mempunyai kemampuan self-renewal dan diferensiasi yang baik. Penelitian ini bertujuan untuk menganalisis literatur mengenai peranan pemberian stem cells terhadap percepatan regenerasi tulang pada fraktur mandibula. Metode: Rapid review dilakukan pada bulan Februari 2021 hingga April 2021. Pencarian artikel mengacu pada pedoman analisis PRISMA dengan menggunakanÂ  strategi PICO melalui database PubMed, Sciences Direct, dan Google Scholar dengan kriteria inklusi berbahasa inggris dari tahun 2011 hingga 2021 serta membahas peranan pemberian stem cells terhadap percepatan regenerasi tulang pada fraktur mandibula. Artikel diseleksi berdasarkan duplikasi, judul dan abstrak, serta keseluruhan isi artikel. Hasil: Dihasilkan 4 artikel penelitian yang menyatakan bahwa kelompok yang diberi stem cells memiliki durasi penyembuhan dan kemampuan penyatuan tulang yang lebih cepat. Kesimpulan: penelitian literatur ini menunjukkan bahwa stem cells berperan dalam proses regenerasi tulang yang terlihat dari terbentuknya kepadatan tulang serta penyembuhan fraktur lebih cepat.Kata Kunci: Stem cells, Regenerasi Tulang, Fraktur mandibula