bluuebunny/crossref_metadata_2025 huggingface dataset:
Racism, Discrimination, and Prejudice
Authors: Fish Jillian , Syed Moin
Published: April 2019

Within the psychological literature, there are numerous definitions of racism available. However, some fail to acknowledge concepts that are often bound up with racism, discrimination, and prejudice—such as power and privilege. In briefly discussing the history of race as a social construct, this entry seeks to understand the function that discrimination and prejudice serve in society. Additionally, shedding light on the process of racial formation provides context for the evolution of racism from overt and blatant to concealed and ambiguous, and embedded throughout society. In highlighting the various forms of racism, discrimination and prejudice, this entry provides an overview of adolescents’ experiences with implicit, subtle, explicit, and institutional racism, and implications for their development and psychological well-being.
Simulating Spanish-English Code-Switching: El Modelo Está Generating Code-Switches
Authors: Tsoukala Chara , Frank Stefan L. , Bosch Antal van den , Valdés Kroff Jorge , Broersma Mirjam
Published: April 2019

Multilingual speakers are able to switch from one language to the other ("code-switch'') between or within sentences. Because the underlying cognitive mechanisms are not well understood, in this study we use computational cognitive modeling to shed light on the process of code-switching.We employed the Bilingual Dual-path model, a Recurrent Neural Network of bilingual sentence production Tsoukala et al. (2017) and simulated sentence production in simultaneous Spanish-English bilinguals. Our first goal was to investigate whether the model would code-switch without being exposed to code-switched training input.The model indeed produced code-switches even without any exposure to such input and the patterns of code-switches are in line with earlier linguistic work Poplack (1980). The second goal of this study was to investigate an auxiliary phrase asymmetry that exists in Spanish-English code-switched production. Using this cognitive model, we examined a possible cause for this asymmetry. To our knowledge, this is the first computational cognitive model that aims to simulate code-switched sentence production.
Mental Control of Musical Imagery: Comparing Tonal and Song Stimuli
Authors: Cotter Katherine , Silvia Paul
Published: April 2019

Mental control of musical imagery is a complex but understudied process that consists of two components: initiation—whether the musical imagery experience began voluntarily or involuntarily—and management—whether instances of control occur after the experience has begun (e.g., changing the song). The present research examined these two components using 11 lab tasks measuring both initiation and management abilities in a sample of 203 undergraduate students. The tasks varied in stimuli composition: 7 tasks used tones and tonal sequences frequently used as stimuli in auditory imagery research, and 4 tasks used stimuli resembling the contents of everyday musical imagery (i.e., song excerpts). Initiation and management abilities were closely related, and people with greater musical expertise showed a smaller difference between initiation and management ability. Similarly, performance on tasks using tones or tonal sequences and tasks using song stimuli were closely related, and people didn’t differ in performance as a function of stimulus type. The present research demonstrates that people’s ability to initiate and to manage musical imagery are strongly linked and that people are equally good at controlling relatively simple musical imagery and imagery of well-known songs.
PERAN ORGANISASI MASYARAKAT DALAM MEMBANGUN HARMONI PASCA KONFLIK ANTARA MASYARAKAT PRIBUMI DENGAN MASYARAKAT PENDATANG DI LAMPUNG TENGAH
Authors: Mustofa Imam
Published: April 2019

Penelitian ini mengkaji tentang peran organisasi masyarakat dalam membangun harmoni pasca resolusi konflik antara masyarakat pribumi dengan masyarakat pendatang di kecamatan Bumi Nabung Kabupaten Lampung Tengah Propinsi Lampung. Penelitian ini dilatarbelakangi konflik yang terjadi di Kecamatan Bumi Nabung pada tanggal 23-24 Februari 2014 yang mengakibatkan korban materiil dan immateriil yang sangat besar. Oleh sebab itu, penelitian ini penting dilakukan sebagai  bahan masukan bagi pihak-pihak terkait untuk menyelesaikan konflik sosial dalam kehidupan masyarakat yang majemuk dan menghasilkan model pembangunan harmoni di tengah-tengah masyarakat yang multi etnis. Penelitian dilakukan melalui beberapa tahapan; tahap studi pendahuluan, pemetaan dan perencanaan, koordinasi dengan pihak-pihak terkait, observasi, pelaksanaan program, dan evaluasi. Dari hasil penelitian dapat disimpulkan bahwa organisasi masyarakat, berperan sangat signifikan dalam resolusi konflik dan menciptakan harmoni. Dalam hal ini di Bumi Nabung dibentuk organisasi Aliansi masyarakat Cinta Damai (ALMACIDA) sebagai forum preventif-antisipatif yang berkomitmen untuk membangun harmoni, menjaga kesatuan dan persatuan masyarakat dan perdamaian di tengah-tengah masyarakat multikultur di Kecamatan Bumi Nabung Kabupaten Lampung Tengah.
NILAI-NILAI ISLAM PADA BANGUNAN MASJID INDRAPURI DI KABUPATEN ACEH BESAR
Authors: Bahri Saeful
Published: April 2019

Tulisan ini menyajikan hasil penelitian tentang nilai akulturasi yang terkandung dalam bangunan masjid Indrapuri, di Aceh. Masjid Indrapuri unik. Keunikan tersebut diantaranya: pertama, Masjid ini mengisyaratkan kepada kita bahwa pada masa lalu di tempat itu telah terjadi sebuah peristiwa yang monumental yaitu peralihan budaya dan ideologi lama kepada budaya dan ideologi yang baru (Hindu ke Islam), kedua, sesugguhnya studi ini adalah studi tentang fenomena keagamaan di masa lalu melalui rumah badah pada masa lalu dalam hal ini masjid. Penelitian ini merupakan penelitian kualitatif, yakni berupa tafsir tinggalan kebudayaan yang berupa arsitektur masjid. Data dikumpulkan melalui wawancara kepada pihak-pihak yang terkait dengan masjid, observasi dan studi literatur untuk menggali data kesejarahan masjid. Penelitian ini menemukan bahwa masjid Indrapuri menggambarkan masjid itu dibangun dalam suasana peralihan budaya, sehingga tampilan nuansa kultur masa lalunya sangat dominan, meskipun dalam beberapa hal menampilkan ketegasan dan kejelasan yang tidak kompromistis.

Kata kunci: Masjid kuno, Masjid Indrapuri, sejarah Aceh, akulturasi budaya.
PELAKSANAAN URUSAN PEMERINTAHAN UMUM DALAM MEMBINA KERUKUNAN BERAGAMA OLEH PEMERINTAH KOTA BANDUNG
Authors: Sagita Novie Indrawati
Published: April 2019

Abstract

Under Law No. 23 of 2014, mentioned that one of the government's business is general government affairs. The general government affairs is the authority of the president that organized by the head of the region as a leader of  administrative work areas. One of the general  government affairs is fostering inter-ethnic harmony, inter-religious, racial and other groups in order to achieve security and stability of local, regional, and national levels. Since the 2014 presidential elections, many dissatisfied group trying to disrupt the stability of the national government. They blew the issues of intolerance of religious differences, including in the city of Bandung.  At the end of 2016, a Moslem organization intimidate Christians worship activities at Sabuga, Bandung. And then, there was an incident that organization known hacking attack against members of the FPI. Issues of religious difference that spread in the community and intolerant actions can potentially bring social conflict and disintegration.  This study used a qualitative method. The analysis is done by integrating the primary data obtained by observation and interview, mass media, expert opinions, and other sources of relevant literature. Research results indicate that the Government of Bandung City quickly enough in addressing the issue of religious intolerance. The coordination and synergy among regional leaders who joined in â€˜Forkopimdaâ€™ both in the city level and district level is very good  to anticipate and prevent the symptoms of social conflict. Therefore, it is necessary for the effective working program of â€˜Forkopimdaâ€™ by forming a task force. The task force is constantly monitoring the situation, security and social order, so when it is known there will be a plan of action that has  potential of social conflict, the local government can overcome early on.
PENGEMBANGAN MADRASAH ALIYAH AKADEMIK (STUDI MAN INSAN CENDEKIA SERPONG)
Authors: Saepudin Juju
Published: April 2019

Tulisan ini menyajikan hasil  penelitian tentang pengembangan Madrasah Aliyah Akademik Insan Cendekia (IC) di daerah. Madrasah Aliyah Negeri (MAN) Insan Cendekia Serpong lahir dari keinginan untuk menjembatani dunia pesantren dengan dunia ilmu pengetahuan dan teknologi tanpa diduga telah menjadi lembaga pendidikan menengah atas yang difavoritkan. Metode pengumpulan data dalam penelitian ini dilakukan dengan cara observasi, wawancara mendalam dan dokumentasi. Hasil analisa data secara induktif dapat diketahui bahwa komitmen MAN Insan Cendekia Serpong sebagai Madrasah Aliyah Akademik untuk mencapai sintesis ideal itu adalah subsidi pemerintah yang kuat untuk sarana prasarana dan subsidi bagi siswa, rekrutmen siswa yang ketat dan guru secara otonomi serta kurikulum yang tajam dan fokus pada pengembangan kemampuan ilmu pengtahuan dan teknologi yang diintegrasikan dengan penguasaan agama melalui pembelajaran yang bertumpu pada tiga bidang hadlarah dengan mengadopsi sistem boarding dari pesantren. Dengan demikian potret MAN Insan Cendekia Serpong sebagai madrasah pencetak calon saintis berkarakter Islam ini bisa menjadi model bagi pengembangan Madrasah Akademik di daerah lainnya.
SURAKARTA BERGERAK (REKONSTRUKSI SEJARAH PERGERAKAN DI SURAKARTA AWAL ABAD KE-20)
Authors: Bakri Syamsul
Published: April 2019

ABSTRACT

This research is the result of a historical research, which aims to reconstruct the emergence and growth of movement in Surakarta in colonial period. This study answers the questions of dynamics and movement in Surakarta, which include: (1) background factors of the dynamics and movement in Surakarta in colonial period, and (2) the form of dynamics and movement. The method used in this study is historical method, which consists of four stages, namely heuristic, source criticism, interpretation, and historiography. The historical paradigm used is that of John Tosh, i.e. to reconstruct history by understanding the social background and circumstances that cause the development of an event, and the direction of its changes. As for the reconstruction of the past, this study uses the model of the central circle. In this model, it is assumed that the incident at the center of the circle will have consequences in the vicinity. In turn, the center of the circle and the surrounding areas will lead to a new center around which will also result in new symptoms. The theory used is the theory of conflict, social movements, and resistance ideology. The use of the social theories is important for the study of history to expand in space (synchronous), in addition to remaining in the basic ground pattern of history that extends in time (diachronic). This study found historical facts that, in a piece of history of the movement in Indonesia, there are various factors and form of the dynamics of movement in Surakarta at colonial period. Dynamics and movement in Surakarta motivated by external factors (pressure from Western imperialism) and internal one (increasing struggle of indigenous organizations and modern media). The form of dynamics and movement in Surakarta are central circular, complex and interrelated in various fields, namely social and cultural sectors, agrarian, economic, political and religion. The results of this research have contributed knowledge to the discipline of history, especially in the exposure and reconstruction of a history fragment of the dynamics and movement of natives (indigenous people) in the revolt imperialism. In addition, the role of religion movement in forming a moving situation is found in this study. It indicates that this research can also contribute to the discipline of History of Islamic Culture.
PENDIDIKAN KEPERCAYAAN TERHADAP TUHAN YANG MAHA ESA: PEMENUHAN HAK SISWA PENGHAYAT DI SEKOLAH
Authors: Zakiyah Zakiyah
Published: April 2019

Artikel ini membahas masalah Pendidikan Kepercayaan terhadap Tuhan Yang Maha Esa di sekolah bagi siswa siswi penghayat Kepercayaan. Tema ini penting untuk dikaji karena masih banyak sekolah yang belum memberikan mata pelajaran â€œPendidikan Kepercayaanâ€ karena berbagai alasan seperti belum adanya perangkat pendukungnya dan adanya pandangan pendidikan Kepercayaan ini bukan merupakan â€œPendidikan Agamaâ€ sebagaimana di atur dalam perundang-undangan. Data dalam tulisan ini diambil dari hasil penelitian yang telah dilakukan pada tahun 2016. Adapun penelitian tersebut menggunakan pendekatan kualitatif dan data dikumpulkan dengan menggunakan metode wawacara dan studi pustaka terhadap dokumen terkait dengan topik penelitian. Riset ini dilakukan di Kabupaten Cilacap dengan pertimbangan di daerah  ini terdapat sekolah-sekolah yang telah memberikan pendidikan Kepercayaan terhadap Tuhan YME bagi peserta didiknya. Data yang terkumpul dianalisis dengan menggunakan perpektif Hak Asasi Manusia. Hasil studi ini menunjukkan bahwa terdapat 14 sekolah mulai dari Sekolah Dasar, Sekolah Menengah Pertama hingga Sekolah Menengah Atas yang telah memberikan layanan pendidikan tersebut. Dalam pelaksanaannya mereka bekerjasama dengan MLKI Cilacap dalam hal penyediaan guru, materi, silabut, KIKD dan soal-soal tes. Hal ini merupakan gambaran pemenuhan hak dasar bagi anak-anak untuk mendapatkan pendidikan agama sesuai dengan keyakinannya
Artikel
Authors: Ma'rifataini Lisa' Diyah
Published: April 2019

Keluhan tentang kekurangan guru pendidikan agama (GPAI) di sekolah selalu terdengar di setiap kesempatan. Secara kuantitas kebutuhan guru agama yang dirilis dibanyak media hanya berdasarkan rasio belum dilakukan penghitungan berdasarkan rumus yang seharusnya. Penelitian ini mencoba menghitung kebutuhan guru pendidikan agama Islam  di sepuluh provinsi berdasarkan PP 74 tahun 2008 tentang kebutuhan guru, mengetahui pola penyediaan GPAI dan mengetahui pola pembinaan GPAI serta mengetahui beberapa opsi kebijakan yang dilakukan pimpinan lembaga. Pendekatan Penelitian ini adalah mixmethode yaitu kualitatif yang didukung oleh data-data kuantitatif. Hasil penelitian menunjukkan 1).secara keseluruhan di 10 provinsi sampel penelitian kekurangan GPAI pada semua jenjang (SD, SMP, SMA dan SMK) sebesar 17396 orang. 2) Posisi GPAI yang ada saat ini,  secara riil pengangkatan dilakukan oleh Kementerian Agama dan Pemerintah Daerah, Pembinaan oleh Kementerian Agama, Tunjangan Profesi Guru (TPG) oleh Kementerian Agama, Pendidikan Profesi Guru oleh Pemerintah Daerah masih memiliki beberapa kekurangan. 3) Moratorium  pengangkatan guru harus segera dicabut, mengingat kondisi darurat guru agama tersebut. 4) Persoalan pembinaan dan peningkatan kapasitas serta profesionalitas GPAI hendaklah dilakukan melalui penguatan KKG dan MGMP PAI menjadi pusat sumber belajar guru (PSBG). 5) Penelitian ini juga menyajikan 4 (empat) opsi kebijakan yang dapat diambil pimpinan Kementerian Agama dengan segala kelebihan dan kekurangannya.
RELEVANSI PEMAHAMAN AGAMA DENGAN INTERAKSI SOSIAL SISWA SMA NEGERI SE-KECAMATAN TANAHSAREAL KOTA BOGOR
Authors: R. M. Dahlan
Published: April 2019

Abstract

Relevance of religious understanding with the Social Isnteraction of State High School Students in Tanahsareal Bogor City

Research from SMAN in Tanahsareal Bogor city, was honored by 331 people.

The methodology used in this study is a quantitative approach using a questionnaire as an instrument, with a sample of 331 from the eleventh grade students of Public High Schools in Tanahsareal Bogor City.

The results show that there is a positive relevance between understanding religion with students' social interactions. The results of the analysis of the two research variables obtained the relevance between religious understanding and social interaction calculated by Pearson. Correlation obtained coefficient value of 0.868. The value of the coefficient of determination in this analysis obtained a value of 0.754, which means that 75.4% of students' social initiator variables could be from religious examination variables. The remaining 24.6% is removed by other causes. The regression equation is Å¶ = 36.624 + 0.618 X.

Based on the results of these studies it can be stated that understanding religion (X), has relevance to student social interaction (Y). This is very relevant to the relevance between religious understanding and social interaction among high school students in Tanahsareal Bogor City.
Authors: Rabitha Daniel
Published: April 2019

This research was conducted on former Gafatar member in Lebak regency, Banten province, in 2016. The study was conducted using a qualitative approach and took the research subject as a case studied from a family that attracted enough public attention in the district. The results showed that the joining of the research subject with Gafatar was based on a desire (vision) to change lives (it moved; arousal dopamine neurotransmitters in the limbic system of the brain). This is the basis of the frame of cognition of research subjects in achieving ideal balance. The decision to prove the truth by supporting the program promoted by Gafatar. And increasingly strengthened as a result of the intensity of communication that was built by the Gafatar management of research subjects. Researchers suggest that those who care, especially the government, to realize a real social work as a good pilot for the community. And local governments (such as RTs and RWs) always carry out dialogues with their citizens in each region as a place to gather information from a number of issues that are being felt by the community.

 

Keywords: Gafatar, Lebak-Banten Regency, Arousal Theory and Social Judgment Theory.
Pengaruh Kualitas Pelayanan terhadap Kepuasan Pelanggan pada Pihak Pengelola Alfahri Mart di Kecamatan Tinambung Kabupaten Polman
Authors: B Indayani
Published: April 2019

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh kualitas pelayanan yang terdiri atas: kehandalan, ketanggapan, empati, jaminan, dan tampilan fisik pada pihak pengelola Alfahri Mart yang berada dekat dengan Pasar Tradisional Tinambung, serta untuk mengetahui variabel yang paling dominan terhadap kepuasan pelanggan pada pihak pengelola Alfahri Mart. Data yang digunakan adalah data primer dan data sekunder. Metode pengumpulan data yang digunakan dalam penelitian ini adalah melakukan wawancara, dan observasi selain melakukan pengumpulan data yang melalui koesioner dan dokumentasi. Metode analisis data menggunakan analisis regresi linear berganda. Hasil yang diharapkan dalam penelitian ini adalah mendapatkan informasi mengenai pengaruh kualitas pelayanan terhadap kepuasan pelanggan dan juga bisa dijadikan bahan pertimbangan bagi manajer dalam melakukan kegiatan evaluasi kualitas pelayanan terhadap kepuasan pelanggan Alfahri Mart. Olehnya itu dari hasil penelitian ini sangat penting dalam rangka menambah wawasan dan pengetahuan yang lebih luas bagi pihak pengelola (manajer dan karyawan) Alfahri Mart tentang bagaimana cara meningkatkan kualitas pelayanan terhadap kepuasan pelanggan.
Analisis Biaya Produksi Terhadap Pembuatan Minyak Goreng di Dusun Talolo Kabupaten Polewali Mandar
Authors: M Nuraeni , Rasadiah Rasadiah
Published: April 2019

Penelitian ini bertujuan : Untuk mengetahui perhitungan biaya produksi Minyak Goreng Mandar. Objek Penelitian adalah usaha kecil pembuat minyak mandar (pattana’ minna’) yang terletak di Dusun Talolo Kecamatan Tinambung Kabupaten Polewali Mandar. Model penelitian ini terdiri dari beberapa metode dalam menentukan harga pokok produksi yaitu dengan menggunakan pendekatan full costing dan variabel costing sebagai alat analisisnya. Hasil penelitian ini menunjukkan bahwa : Pembuat minyak dalam menentukan harga jual tidak menggunakan perhitungan yang sesuai dengan aturan akuntansi yang ada.
Pengaruh Prospek Penghargaan Finansial terhadap Minat Mahasiswa Akuntansi dalam Pemilihan Karir Menjadi Akuntan Publik (Studi Kasus pada Mahasiswa Akuntansi Universitas Sulawesi Barat)
Authors: Ratnasari Sri Astuty , Tamsil Melinda
Published: April 2019

Penelitian ini berjudul pengaruh prospek penghargaan finansial terhadap minat mahasiswa akuntansi dalam pemilihan karir menjadi akuntan publik (studi kasus pada mahasiswa akuntansi Universitas Sulawesi Barat). Tujuan penelitian ini ialah untuk mengetahui apakah prospek penghargaan finansial berpengaruh terhadap minat mahasiswa akuntansi berkarir menjadi Akuntan publik. Penelitian ini menggunakan kuesioner sebagai alat untuk mengumpulkan data primer. Populasi sekaligus sampel dalam penelitian ini adalah mahasiswa akuntansi fakultas ekonomi Universitas Sulawesi Barat angkatan 2013 yang berjumlah 37 responden. Hasil penelitian ini adalah bahwa prospek penghargaan finansial berpengaruh positif dan signifikan terhadap minat mahasiswa akuntansi untuk berkarir menjadi Akuntan publik. Hal ini dibuktikan melalui analisis regresi linier sederhana yang diperoleh nilai R Square sebesar 0,312, yang diartikan bahwa besarnya pengaruh prospek penghargaan finansial adalah 31,2% dan sisanya sebesar 68,8% dipengaruhi oleh variabel lainnya. Hasil uji t statistik menghasilkan nilai signifikansi yang lebih kecil dari level of significant yaitu 0,001 < 0,05. Selain itu, hasil output SPSS, dapat dilihat juga perbandingan antara thitung dan ttabel nya yang memperoleh nilai thitung sebesar 3,564 sedangkan ttabel sebesar 2,051. Oleh karena thitung lebih besar dari ttabel yaitu 3,564 > 2,051 maka diartikan bahwa hipotesis (H1) diterima.
Активність системного запалення низької градації в пацієнтів з резистентною артеріальною гіпертензією
Authors: Mishchenko L. A. , Matova O. O. , Sheremet M. Yu. , Serbeniuk K. I. , Kuchmenko O. B.
Published: April 2019

The aim – to study the activity of low-grade inflammation and determine an interaction of its parameters with characteristics of humoral systems of blood pressure regulation, hypertensive heart and kidney damage in patients with resistant arterial hypertension (AH).Material and methods. The results of examination of 129 patients with AH (72 patients with controlled AH, 57 persons with resistant AH) were included into the analysis. All patients, besides routine clinical examination, underwent 24-hours’ blood pressure monitoring, evaluation of systemiс inflammation markers (C-reactive protein, fibrinogen, IL-6, TNF-α), MMP-12 activity, cystatin C, renin, aldosterone, citrulline blood concentration; 24-hours’ excretion of albumin and metanephrine. Results. In the resistant AH, compared to the patients with controlled arterial hypertension, higher levels of inflammation active phase proteins (C-reactive proteins – by 17.3 %, fibrinogen – by 10.6 %) and proinflammatory cytokines (IL-6 by 21.8 % TNF-α by 13 %) were detected. The activation of low-grade inflammation in patients with resistant AH has been associated with higher renin-angiotensin-aldosterone system activity: the concentration of plasma aldosterone correlated with IL-6 level (r=0.334; Р=0.03) and matrix metalloproteinase 12 activity (r=0.326; Р=0.02); active renin blood contents – with IL-6 (r=0.416; Р=0.01) and TNF-α (r=0.323; Р=0.03) levels). In patients with resistant AH the increase of left ventricle myocardial mass index was accompanied by elevation of plasma IL-6, and decrease of glomerular filtration rate was associated with growth of plasma TNF-α blood level (r=0.318; Р=0.04). Correlation of MMP-12 activity with renal impairment markers – cystatin С (r=0.405; Р=0.01) and citrulline (r=0.338; Р=0.03) was detected. In resistant AH pts increase of LVMI was accompanied by elevation of IL-6.Conclusions. Resistant AH was characterized by more expressed activation of low – grade inflammation, compared to controlled AH, which is associated with renin-angiotensin-aldosterone system activation and hypertensive injury of heart and kidneys.
Стан ниркової функції в пацієнтів із хронічною серцевою недостатністю зі зниженою фракцією викиду лівого шлуночка залежно від клінічних показників та параметрів гемодинаміки
Authors: Voronkov L. G. , Dudnik G. Ye. , Lyashenko A. V.
Published: April 2019

The aim – to examine the relationship between parameters of the renal function and main characteristics in patients with chronic heart failure and reduced left ventricular ejection fraction during their clinical and instrumental examination.Material and methods. The present analysis includes 134 patients and reduced left ventricular ejection fraction with II–IV New York Heart Association (NYHA) classes. All patients were in stable clinical condition. Baseline measurements included height, weight, blood preasure, heart rate, NYHA classification. All patients were examined by routine ECG, echocardiography. Glomerular filtration rate (GFR) was estimated using the CKD-EPI equation. Daily microalbuminuria and urinary albumine/creatinine ratio were determined. Definitions of levels of blood urea nitrogen, uric acid, interleukin-6, NT-proBNP and citrulin were performed. All patients received standard treatment.Results. The performed study demonstrated the role of GFR as indicator most closely related to the clinical characte­­ristics of the examined patients (NYHA class, age, hypertension, diabetes, anemia) and levels of interleukin-6 and citrulline. Microalbuminuria level and albumin/creatitine ratio in urine did not show a similar relation, except for the NYHA class. Blood urea nitrogen was higher in patients with higher NYHA class and with concomitant diabetes and anemia. All studied parameters of the renal function revealed a reliable association with uric acid level. There were no significant (P<0.05) relationships between renal function parameters and systolic blood pressure, heart rate, left ventricular ejection fraction and flow-dependent vasodilator response of the brachial artery, as well as the level of NT-proBNP in plasma.Conclusions. Among stable patients with chronic heart failure and reduced left ventricular ejection fraction, there were significantly lower levels of GFR in patients with III–IV NYHA classes, in older women (≥ 63 years) and in patients with hypertension, diabetes and anemia. The level of GFR was directly related to the level of circulating biomarkers, such as uric acid, interleukin-6 and citrulline. The levels of microalbuminuria, urinary albumine/creatinine ratio, blood urea nitrogen were significantly higher in patients with ІІІ–ІV NYHA classes.
Асоціації рівня васкулоендотеліального фактора росту А з показниками гемодинаміки у хворих, що перенесли інфаркт міокарда з елевацією сегмента ST
Authors: Petyunina O. V. , Kopytsya M. P.
Published: April 2019

The aim – to research associations between vascular endothelial growth factor-A (VEGF-A) level and left ventricular remodeling after ST elevation myocardial infarction (MI). Material and methods. 62 patients with MI, 51 (82.3 %) male and 11 (17.7 %) female at average age 58.63±8.90 years were enrolled into the study. VEGF-A level was determined on the 7th day of MI by enzyme-linked immunoassay. Anxiety level was assessed by Taylor questionnaire during the period of 10–14 days before MI. After 6-month observation 47 patients were assessed. Results. In patients with MI in comparison with the control group significant rise of serum VEGF-A level was observed, showing positive correlation with creatine kinase level. The level of VEGF-A below median 160 pg/ml in comparison with its level above the median 160 pg/ml was associated with higher frequency of MI in men (Р=0.023), anxiety before MI (Р=0.019), end diastolic diameter (EDD), end systolic diameter (ESD), end diastolic volume (EDV) increase in acute phase, EDD, ESD, EDV, left ventricular myocardial mass, Е/А, lower exercise tolerance after 6-month observation. This processes indicates unfavorable role of low VEGF-A levels and protective – of high VEG-A levels for intracardiac hemodynamic after myocardial infarction. The level of VEGF-A ≤ 201.86 pg/ml with sensitivity 57.9 % and specificity 85.7 % (AUC 0.711; 95 % CI 0.513–0.908; Р=0.036) have prognostic significance for adverse remodeling development. Conclusions. VEGF-A level – important indicator to estimate the extent of myocardial injury and pathologic remodeling development.
Вплив інтервальних нормобаричних гіпоксичних тренувань на мікроциркуляторну ланку системи крово­обігу та показники вуглеводного і ліпідного обмінів у осіб похилого віку з предіабетом
Authors: Chyzhova V. P.
Published: April 2019

The aim – to understand effects of intermittent hypoxia training (IHT) in prediabetes patients 60 years age and over on microcirculatory system, glucose homeostasis and lipids.Material and methods. A total of 82 subjects of different age were included into this analysis. All of them underwent glucose tolerance test (GTT). After GTT 19 prediabetes people 60 years age and over continued investigation with determination of plasma glucose, insulin and cortizol. Insulin sensitivity was evaluated by homeostasis model assessment of insulin resistance (HOMA-ІR). Lipid profile, endothelial function and microcirculatory system were studied before and after IHT in prediabetes patients 60 years age and over.Results. It was shown that IНT promotes the normalization of carbohydrate metabolism in the elderly prediabetes people. Favorable changes were observed after the IHT course: the percentage of people with pre-diabetic disorders decreased from 100 % to 42.1 % (Р<0.01). One month after the IHT, an increase in the normalizing effect on the carbohydrate metabolism was noted: a statistically significant decrease in the fasting glucose from 5.8±0.2 to 5.5±0.2 mmol/l (Р<0.05), after 2 hours GTT – from 8.5±0.2 to 7.0±0.4 mmol/l (Р<0.01). Pre-diabetic disorders were detected in 15.8 % of the subjects (Р<0.001) after 1 month of IHT. In prediabetes subjects after course use of IHT there was statistically significant decrease in total cholesterol and cholesterol of low density lipoproteins. Conclusions. The use of IHT is promising for correction of prediabetes disorders in the elderly, which reduces not only the risk of developing type 2 diabetes but also prevents cardiovascular complications.
Хірургічна реваскуляризація міокарда при стабільній ішемічній хворобі серця. Quo vadis?
Authors: Yepanchintseva O. A. , Zharinov O. J. , Todurov B. M.
Published: April 2019

The article reviews contemporary data on role of the coronary artery bypass grafting (CABG) in patients with stable ischemic heart disease. The principles of pre-surgery risk assessment and choice between CABG and percutaneous coronary intervention are provided. Based on the results of the controlled studies, the indications for CABG were established in guidelines. The evaluation of the myocardial viability and coronary reserve may improve patient selection for revascularization procedures. Evidence base regarding predictors of early postoperative complications and results of the long-term observation of patients after CABG is provided. Possible intermediate ctiteria of revascularization efficiency are changes of left ventricular pump function and quality of life parameters. A special attention is devoted to the perspectives of new surgical technologies to improve CABG results.
Тахикардии с широкими комплексами QRS: дифференциальная диагностика и неотложная терапия
Authors: Solovyan G. M. , Mikhalieva T. V.
Published: April 2019

The lecture is devoted to a serious problem in clinical practice – diagnosis and treatment of wide QRS complex tachycardia, requiring an individual approach. The main principles of the detection of different types of wide QRS complex tachycardia and their electrophysiological mechanisms are considered. The article deals with etiology of wide QRS complex tachycardia, as well as clinical and electrocardiographic criteria for differential diagnosis between ventricular tachycardia and supraventricular tachycardia with aberrant conduction. Key aspects of wide QRS complex tachycardia are discussed, and the ECG examples of certain forms of wide QRS complex tachycardia are presented. The principles of emergency care and long-term therapy for narrow and wide QRS complex tachycardia are considered. Information regarding antiarrhythmic drugs usage and general principles of catheter treatment of tachycardia is provided.
Порівняльна клініко-інструментальна характе­­ри­стика пацієнтів із хронічною серцевою недостатністю та зниженою фракцією викиду лівого шлуночка без анемії залежно від наявності залізодефіциту
Authors: Voronkov L. G. , Gorbachova V. V. , Liashenko A. V. , Gavrilenko T. I. , Mhitaryan L. S. , Yakushko L. V. , Paraschenyuk L. P.
Published: April 2019

The aim – to compare patients with chronic heart failure (CHF) and reduced left ventricular ejection fraction (LVEF) without anemia depending on the presence of iron deficiency (ID) according to the main clinical, hemodynamic, laboratory parameters and prognosis indicators. Material and methods. In January – February, 2018, 95 stable patients with CHF (83 of men and 12 of women), 18–75 years old, NYHA class II–IV, with left ventricular ejection fraction < 40 % were screened. Patients were included during clinical compensation phase. Quality of life was assessed by the Minnesota living with heart failure questionnaire (MLHFQ), physical activity was estimated by the Duke University index, functional status – by assessing the 6-minute walking test and a standardized lower limb extension test.Results. ID was found in 51 out of 95 patients without anemia. Patients with ID without anemia were reliably in higher functional class, had a lower body mass index, lower systolic blood pressure, glomerular filtration rate, worse 6-minute walking test and thigh quadriceps endurance and a lower quality of life by MLHFQ. They also had lower hemoglobin, MCV, MCH, hepcidin levels and higher NT-proBNP, interleukin 6, and citrulline levels. The presence of ID, even without concomitant anemia, increased both risk of death from any cause and the combined critical event risk (death or hospitalization) during 12 and 24 months.Conclusions. Among patients with CHF and reduced LVEF without anemia, ID was observed in 54 % of patients. Patients with ID were characterized by a greater proportion of patients in NYHA class III–IV and renal dysfunction, poorer functional capacity (6-minute walking test, thigh quadriceps endurance), poorer quality of life, lower body mass index, lower systolic blood pressure and lower hemoglobin and hepcidin levels along with higher circulating interleukin 6, citrulline and NT-proBNP levels. ID without concomitant anemia was associated with worse survival and more frequent hospitalizations.
Предиктори великих несприятливих клінічних подiй після шунтування вінцевих артерій у пацієнтів зі стабільною ішемічною хворобою серця при трирічному спостереженні
Authors: Yepanchintseva O. A. , Mikhaliev K. O. , Zharinov O. J. , Todurov B. M.
Published: April 2019

The aim – to establish predictors of late major adverse outcomes (MAOs) in patients (pts) with stable coronary artery disease (CAD) after coronary artery bypass grafting (CABG) at three years follow-up.Material and methods. An observational single-center study included 251 consecutive pts with stable CAD (mean age (61±9) years, 218 (86.9 %) males, 33 (13.1 %) females), after isolated CABG. At three years follow-up, MAOs were registered: death – 11 (4.4 %) cases (among them – 9 cardiovascular death cases); myocardial infarction – 4 (1.6 %); unstable angina – 11 (4.4 %); stroke – 5 (2.0 %); heart failure (HF) decompensation – 20 (8.0 %); sustained ventricular tachycardia – 3 (1.6 %); repeated myocardial revascularization – 10 (4.0 %); peripheral artery embolism – 1 (0.4 %). In total, MAOs occurred in 55 (21.9 %) pts.Results. At univariate analysis, MAOs were related to the following parameters: age; body mass index; HF IIB stage; permanent AF; estimated glomerular filtration rate (eGFR); left atrium antero-posterior dimension, indexed by body surface area (LAD/BSA); left ventricular (LV) end-diastolic volume index; aortic and mitral valve regurgitation; LV ejection fraction (EF); and early major postoperative complications. At multivariate analysis, the independent predictors of MAOs were following: worse LV systolic function at discharge (by LV EF grades (< 40 % vs 40–49 % vs ≥ 50 %): odds ratio (OR) 2.145 (95 % confidence interval (CI) 1.382–3.329); Р=0,001); worse eGFR at baseline (per each 30 ml/(min • 1.73 m2) decrease vs ≥ 90 ml/(min • 1,73 m2): OR1.951 (95 % CI 1.112–3.421); Р=0.020) and larger LAD/BSA (by degrees of enlargement: OR 1.918 (95 % CI 1.119–3.289); Р=0.018).Conclusions. At three years follow-up, MAOs in pts with stable CAD after CABG were associated with worse baseline filtration kidney function, larger baseline LAD, and worse LV systolic function at discharge. Independent predictive value of baseline eGFR and LAD, and LV EF at discharge should be take into account while planning the postoperative follow-up schedule, as well as individualized prevention of late cardiovascular outcomes.
Вплив статинів на показники імунного запалення залежно від їх вихідного рівня в пацієнтів зі стабіль­­­ною ішемічною хворобою серця
Authors: Lomakovsky O. M.
Published: April 2019

The aim – to determine the effect of statins upon parameters of immune inflammation, depending on their initial disturbances in patients with stable coronary artery disease.Material and methods. 54 patients with stable angina pectoris were examined. Venous blood was taken before and after two months of treatment with atorvastatin (20 mg/day) (n=22) or lovastatin (40 mg/day) (n=12) or simvastatin (40 mg/day) (n=20). Immunological parameters such as TNF-α, IL-6, IL-8, IL-10, high-sensitivity CRP, antibodies to low-density oxidized lipoproteins, number of cells with CD40 receptors, functional-metabolic activity of neutrophils and monocytes, and subpopulations of lymphocytes were determined.Results. Two-month statin administration in equivalent doses led to a moderate decrease in the synthesis of mononuclear cells of proinflammatory cytokines (TNF-α, IL-8) and decrease of functional activity of monocytes in the general group of patients with stable coronary heart disease. The influence of statins on humoral and cellular factors of immune inflammation directly depended on the initial factor level (R=0,32–0,77; Р=0,04–0,00001).Сonclusions. Statins affect the adaptive and innate links of immunity in patients with stable ischemic heart disease. The effect of statins on humoral (CRP, ТNF-α, IL-6, IL-8, IL-10) and cellular (monocytes, Th, Ts, Th/Ts) factors of immune inflammation in patients with IHD directly depends on the initial level of the factor. The more the initial level of the indicator is changed relative to the control, the greater the normalizing effect of the same dose of statins.
Предиктори виникнення ранніх ускладнень після аорто­­коронарного шунтування в пацієнтів зі ста­­­більною ішемічною хворобою серця
Authors: Shklianka I. V. , Zharinov O. J. , Mikhaliev K. O. , Yepanchintseva O. A. , Todurov B. M.
Published: April 2019

The aim – to determine factors that may influence on the occurrence of early postoperative complications (EPC) of surgical myocardial revascularization in patients with stable coronary heart disease and to study the effect of peri­­operative drug therapy. Material and methods. In a single-center study, data from a prospective study of 155 patients with stable coronary heart disease consecutively selected for isolated coronary artery bypass graft surgery (CABG) were analyzed. In total, 84 EPC were registered in 66 patients during the hospital period; 89 patients had no complications. Groups of patients with and without complications were compared according to demographic parameters, risk factors, concomitant diseases, perioperative therapy, features of the CABG operation.Results. Most of the early complications (56 %) were the cases of postoperative atrial fibrillation/flutter. In unifactor analysis, the features of patients with complications in the early postoperative period were the presence of severe diabetes (Р=0.025), obesity of I and II degrees (Р=0.070), left ventricle hypertrophy (median (quartiles) 47.9 (41.8–63.1) g/m2.7 vs 43.6 (36.5–55.2) g/m2.7; Р=0.008), the left atrium increase size (median (quartiles) 4.3 (4.2–4.6) cm vs 4.2 (4.0–4.5) cm; Р=0.068); elevated preoperative level of IL-6 (median (quartiles) 4.1 (3.1–9.0) pg/ml vs 3.2 (2.0–5.1) pg/ml; Р=0.044); the absence of statin therapy in perioperative period (Р<0.001) and a long duration of aortic clamping (median (quartiles) 20 (15–25) min vs 17 (13–23) min; Р=0.049). According to the multivariate analysis, the risk of EPC after CABG was 6.25 times higher among patients who did not take statins in the perioperative period, compared to patients who received high-intensity statins for ≥ 7 days. In patients with severe diabetes, the risk of EPC was 1.96 times higher than in patients with mild diabetes.Conclusions. The presence of severe diabetes and the absence of statin therapy in the perioperative period proved to be independent predictors of the occurrence of EPC. High-intensity statins therapy for ≥ 7 days prior to surgery allowed to reduce the risk of EPC, in particular, post-operative atrial fibrillation/flutter.
Характеристика клінічного перебігу гострого коронарного синдрому без елевації сегмента ST на тлі есенціальної артеріальної гіпертензії в чоловіків та жінок, інфікованих Helicobacter pylori
Authors: Shved M. I. , Hanych T. M.
Published: April 2019

The aim – to investigate the acute coronary syndrome without ST segment elevation and concomitant essential hypertension clinical presentation in men and women with Helicobacter pylori infection. Material and methods. 197 acute coronary syndrome without ST segment elevation patients (age 45–83 years) with essential arterial hypertension and dyspesia were investigated according to the current clinical protocols with total antibodies to Helicobacter pylori rate detection. The patients were divided by the groups of men and women, infected and uninfected with Helicobacter pylori. The clinical presentation of acute coronary syndromes was evaluated using the 13-item Acute coronary syndrome symptoms checklist and the dyspepsia symptoms were estimated by the Likert scale. Results. In case of Helicobacter pylori infection compared to uninfected patients a significantly higher severity of chest pain, shoulder pain and upper back pain had been revealed, while among women the chest discomfort, sweating and palpitations significantly prevailed. The intensity of dyspeptic symptoms, especially heartburn and nausea, was significantly higher among women infected with Helicobacter pylori. A significant progression of heart failure with higher prevalence of edema and liver enlargement were revealed in men infected with Helicobacter pylori versus uninfected and in men versus women regardless of Helicobacter pylori infection factor. Conclusions. The obtained link between the total antibodies to Helicobacter pylori titer and the patients’ age, male gender, myocardial infarction history, the prevalence of edema and liver enlargement might indicate a significant clinical course deterioration and heart failure progression in elderly male patients with acute coronary syndromes without ST segment elevation and essential hypertension in case of Helicobacter pylori infection.
Порівняльна ефективність спіронолактону, еплеренону, небівололу і моксонідину у хворих на резистентну артеріальну гіпертензію
Authors: Mishchenko L. A. , Matova O. O. , Sheremet M. Yu. , Serbeniuk K. I.
Published: April 2019

The aim – to study the effectiveness of spironolactone, eplerenone, nebivolol, moxonidine as the 4th component of therapy in patients with resistant arterial hypertension.Material and methods. The study involved 66 patients with true resistant arterial hypertension (RAH). The average age of patients was 51.9±1.2 years, mostly men (59.1 %). In addition to standard triple-dose fixed combination antihypertensive tharepy, all patients received in turn spironolactone (45.0±3.6 mg/day), eplerenone (47.9±2.1 mg/day), nebivolol (8.9±0.6 mg/day) and moxonidine (0.5±0.1 mg/day). After completion of each stage, after 3 months of therapy, all patients have been assessed an office blood pressure measurements and ABPM.Results. In patients with RAH, the addition standardized therapy with a triple fixed-dose combination of antihypertensive drugs, antagonists of mineralocorticoid showed better effectiveness than nebivolol and moxonidine: the target level of BP with treatment of spironolactone was achieved in 68.2 % patients, eplerenone – 65.2 %, whereas in the groups of nebivolol and moxonidine – in 53.9 % and 56.2 %, respectively. The predictors of the effectiveness of the antagonists of the mineralocorticoid receptors are increasing plasma aldosterone concentrations (β=0.653; Р=0.002) and ARR values (β=0.542; Р=0.003), while the β-blocker and imidazolin receptor agonist were more effective in older patients (β=0.425; Р=0.02) along with increase of average daily pulse (β=0.315; P=0.04) and excretion of urine metanephrines (β=0.382; Р=0.01).Conclusoins. Spironolactone and eplerenone are drugs of choice for adding to triple fixed-dose combination in patients with RAH. They were significantly more effective than beta-blocker (nebivolol) and an imidazolin receptor agonist (moxonidine).
Когнітивна функція та прихильність до лікування в пацієнтів із хронічною серцевою недостатністю та зниженою фракцією викиду лівого шлуночка: зв’язок і прогностичне значення
Authors: Voronkov L. G. , Solonovych A. S. , Lyashenko A. V. , Revyenko I. L. , Yakushko L. V. , Paraschenyuk L. P.
Published: April 2019

The aim – to investigate the relationship between cognitive function and adherence to treatment; to evaluate the predictive value of adherence to treatment questionnaires in patients with chronic heart failure (CHF) and reduced left ventricular ejection fraction (LVEF).Material and methods. 124 pts with stable CHF and reduced (< 40 %) LVEF NYHA II–IV not older than 75 years were examined. Besides routine clinical examination, standard neuropsychological tests (Mini Mental State Examination – MMSE, Schulte test, the HADS scale) were used. To assess adherence to the treatment, the Moriski – Green questionnaire and the disease-specific questionnaire of heart failure department were used. Cognitive dysfunction was defined as MMSE ≤ 26 points.Results. After distribution of pts to three groups depending on their adherence to treatment, it was found that they significantly differed in MMSE and Shulte test results. The number of points regarding adherence to treatment (Moriski – Green questionnaire and the questionnaire of heart failure department) directly correlated with MMSE (P=0.038 and P=0.023, respectively). The group of patients with high compliance had significantly better cognitive tests results (MMSE and Schultze) than the group of patients with moderate/low compliance – this was equally relevant to both questionnaires. The construction of survival curves showed that Moriski – Green questionnaire had no reliable prognostic significance both in relation to death and combined critical event (mortality/hospitalization) (P=0.113 and P=0.401, respectively); At the same time, the disease-specific questionnaire of heart failure department showed value regarding the prediction of long-term survival and the onset of a combined critical event (P=0.046 and P=0.024, respectively).Conclusion: More than half of pts with CHF and reduced LVEF have low and moderate adherence to treatment, which is associated with worse cognitive tests results (MMSE and Schulte). Evidence of relationship between adherence to treatment and cognitive function evaluated using our questionnaire were comparable to those obtained by Moriski – Green questionnaire. Using disease-specific questionnaire of heart failure department had a high value in predicting long-term survival and the onset of combined critical event (death or hospitalization) in patients with CHF and reduced LVEF, while the Moriski – Green questionnaire did not demonstrate the above-mentioned predictive value.