bluuebunny/crossref_metadata_2025 huggingface dataset:
Bribery and Other Serious Investor Misconduct in Asian International Arbitration
Authors: Teramura Nobumichi , Nottage Luke , Jetin Bruno
Published: April 2024

Bribery and other serious illegal behaviour by foreign investors face wide condemnation in any society. Yet there remains a lack of consensus on the consequences of corruption and illegality affecting international investment, and especially in investment arbitration—a transnational procedure to resolve disputes between a foreign investor and a host state. A core issue is whether a foreign investor violating a host state's law should be awarded protection of its investment, as per its contract with the host state and/or the applicable investment or trade agreement between the home state and the host state. Some suggest such protection would be unnecessary, as the investor committed a crime in the host state, while others attempt to establish an equilibrium between the investor and the host state. Some others claim to protect investment, invoking the sanctity of promises made. This book explores Asian approaches towards the issue, setting it in the wider political economy and domestic law contexts. It also considers the extent to which significant states in Asia are or could become ‘rule makers’ rather than ‘rule takers’ regarding corruption and serious illegality in investor–state arbitration.
Corruption and Illegality in Asian Investment Disputes: Indonesia
Authors: Butt Simon , Crockett Antony , Lindsey Tim
Published: April 2024

Indonesia is notorious for high levels of corruption. This has remained the case in spite of significant reforms made since the collapse of the Soeharto government in 1998. This chapter briefly introduces some of the key law reforms which have sought to address corruption in Indonesia as well as ongoing concerns regarding high levels of corruption in the judicial system, which is one of the factors leading investors in Indonesia to prefer arbitration for resolving disputes. The chapter then considers the legal framework for international commercial arbitration in Indonesia, particularly relating to enforcement of arbitration awards and recent changes to Indonesia's policy relating to investment treaties and investor–state dispute resolution. The chapter includes consideration of two investor–state arbitrations involving Indonesia which featured allegations of corruption.
Foreign Investment, Treaties, Arbitration and Corruption: Comparing Japan
Authors: Nottage Luke , Teramura Nobumichi
Published: April 2024

Japan emerged from the 1980s as a leading net exporter of foreign direct investment, with very little corruption. Since 2001, it has accelerated ratifications of standalone bilateral investment treaties as well as investment chapters in free trade agreements. Almost all allow foreign investors from the home state to directly initiate investor–state dispute settlement (ISDS) arbitration against host states to get relief from violations of substantive treaty commitments. Japan’s investment treaty practice on corruption and illegality is intriguing. First, from around 2007, its treaties have often urged host states to take measures against corruption. This should help Japan’s outbound investors. Second, Japan’s treaties have been less consistent in expressly limiting their protections to foreign investments made in accordance with host state laws. This can again benefit Japanese outbound investors as claimants, as the absence of a legality provision renders more difficult defences from host states, which typically have more corruption than in Japan. Japan may adopt more and clearer legality provisions if subjected to more inbound ISDS arbitration claims and/or if claims by Japanese outbound investors are mostly against well-governed host states with little scope for corruption. Yet both types of claims remain few. The shift may therefore come more from other counterparty states pushing for such legality provisions and Japan agreeing in its future treaties to demonstrate its overall commitment to combatting corruption, and to preserve the legitimacy of the ISDS arbitration system.
The Effect of Corruption on Foreign Direct Investment at the Regional Level: A Positive or Negative Relationship?
Authors: Jetin Bruno , Saadaoui Jamel , Ratiarison Haingo
Published: April 2024

This chapter looks at the effect of corruption on foreign direct investment (FDI) at the world and regional levels, with a focus on East, South and Southeast Asia. The academic literature is inconclusive because the nature of corruption can be different from one country to another and because various other factors can decide whether a foreign company will invest in a country or region despite a relatively high level of corruption. To shed light on the effect of corruption, the authors proceed to a paneleconometrics investigation that assesses the relationship between the stock of FDI and the‘control of corruption’, published by the World Bank, for a sample of 180 countries over the period 2002–2019. The‘control of corruption’ index combines 23 different assessments and surveys capturing perceptions of the extent to which public power is exercised for private gains. A low score means that the authorities do not fight corruption or are not effective in fighting it, and therefore corruption is high; and vice versa. The authors include two control variables (real GDP and secondary school enrolment) to better estimate the specific role of corruption. Their results show that at the world level, thecontrol of corruption is low and has a positive effect on FDI, which means that corruption is a stimulus to FDI, in line with Egger and Winner's findings. However, in East Asia, Southeast Asia, Australiaand New Zealand, corruption has a ‘grabbing hand’ effect. In theEuropean Union, corruption is a helping hand. The authors’ results confirm the importance of a regional approach to the analysis of the effect of corruption on FDI.
Multi-Dynamic-Multi-Echo-based MRI for the Pre-Surgical Determination of Sellar Tumor Consistency: a Quantitative Approach for Predicting Lesion Resectability
Authors: Yildirim Mehmet Salih , Schmidbauer Victor Ulrich , Micko Alexander , Lechner Lisa , Weber Michael , Furtner Julia , Wolfsberger Stefan , Malla Houech Intesar-Victoria , Cho Anna , Dovjak Gregor , Kasprian Gregor , Prayer Daniela , Marik Wolfgang
Published: April 2024

Purpose

Pre-surgical information about tumor consistency could facilitate neurosurgical planning. This study used multi-dynamic-multi-echo (MDME)-based relaxometry for the quantitative determination of pituitary tumor consistency, with the aim of predicting lesion resectability.

Methods

Seventy-two patients with suspected pituitary adenomas, who underwent preoperative 3 T MRI between January 2020 and January 2022, were included in this prospective study. Lesion-specific T1-/T2-relaxation times (T1R/T2R) and proton density (PD) metrics were determined. During surgery, data about tumor resectability were collected. A Receiver Operating Characteristic (ROC) curve analysis was performed to investigate the diagnostic performance (sensitivity/specificity) for discriminating between easy- and hard-to-remove by aspiration (eRAsp and hRAsp) lesions. A Mann-Whitney-U-test was done for group comparison.

Results

A total of 65 participants (mean age, 54 years ± 15, 33 women) were enrolled in the quantitative analysis. Twenty-four lesions were classified as hRAsp, while 41 lesions were assessed as eRAsp. There were significant differences in T1R (hRAsp: 1221.0 ms ± 211.9; eRAsp: 1500.2 ms ± 496.4; p = 0.003) and T2R (hRAsp: 88.8 ms ± 14.5; eRAsp: 137.2 ms ± 166.6; p = 0.03) between both groups. The ROC analysis revealed an area under the curve of 0.72 (95% CI: 0.60–0.85) at p = 0.003 for T1R (cutoff value: 1248 ms; sensitivity/specificity: 78%/58%) and 0.66 (95% CI: 0.53–0.79) at p = 0.03 for T2R (cutoff value: 110 ms; sensitivity/specificity: 39%/96%).

Conclusion

MDME-based relaxometry enables a non-invasive, pre-surgical characterization of lesion consistency and, therefore, provides a modality with which to predict tumor resectability.
National standardisierter Broad Consent in der Praxis: erste Erfahrungen, aktuelle Entwicklungen und kritische Betrachtungen
Authors: Zenker Sven , Strech Daniel , Jahns Roland , Müller Gabriele , Prasser Fabian , Schickhardt Christoph , Schmidt Georg , Semler Sebastian C. , Winkler Eva , Drepper Johannes
Published: April 2024

Hintergrund

Die Digitalisierung im Gesundheitswesen verspricht eine Sekundärnutzung von Patientendaten im Sinne eines lernenden Gesundheitssystems. Die Arbeitsgruppe Consent der Medizininformatik-Initiative (MII) hat mit einheitlichen Einwilligungsdokumenten eine ethische und rechtliche Grundlage hierfür geschaffen. Beschrieben wird die systematisch begleitete Einführung dieser Dokumente an den Standorten der MII.

Methoden

Die Begleitung der Einführung umfasste regelmäßige Online-Umfragen, die vertiefte Analyse der Einführungsprozesse an ausgewählten Standorten sowie die Untersuchung der jeweils eingesetzten Dokumente. Zudem wurden Anfragen und Rückmeldungen einer Vielzahl von Stakeholdern ausgewertet.

Ergebnisse

Die Online-Umfragen ergaben, dass 27 der 32 befragten Standorte nach und nach die Einwilligungsdokumente produktiv eingeführt haben, mit aktuell insgesamt 173.289 Einwilligungen. Die Analyse der Umsetzungsverfahren offenbarte heterogene organisatorische Rahmenbedingungen an den Standorten. Anforderungen verschiedener Stakeholder konnten durch die Erarbeitung und Bereitstellung ergänzender Versionen der Einwilligungsdokumente und zusätzlicher Informationsmaterialien erfüllt werden.

Diskussion

Die Einführung der Einwilligungsdokumente der MII an den Universitätskliniken schafft eine einheitliche Rechtsgrundlage für die Sekundärnutzung von Patientendaten. Die flächendeckende Implementierung innerhalb der Standorte bleibt jedoch herausfordernd. Minimalanforderungen an die Patientenaufklärung und ergänzende Best-Practice-Empfehlungen sind hierfür zu erarbeiten. Die Weiterentwicklung des nationalen Rechtsrahmens für die Forschung wird die hier entwickelten Mitsprache- und Transparenzmechanismen für Betroffene nicht obsolet machen.
Abundant transcriptomic alterations in the human cerebellum of patients with a C9orf72 repeat expansion
Authors: Udine Evan , DeJesus-Hernandez Mariely , Tian Shulan , das Neves Sofia Pereira , Crook Richard , Finch NiCole A. , Baker Matthew C. , Pottier Cyril , Graff-Radford Neill R. , Boeve Bradley F. , Petersen Ronald C. , Knopman David S. , Josephs Keith A. , Oskarsson Björn , Da Mesquita Sandro , Petrucelli Leonard , Gendron Tania F. , Dickson Dennis W. , Rademakers Rosa , van Blitterswijk Marka
Published: April 2024

The most prominent genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) is a repeat expansion in the gene C9orf72. Importantly, the transcriptomic consequences of the C9orf72 repeat expansion remain largely unclear. Here, we used short-read RNA sequencing (RNAseq) to profile the cerebellar transcriptome, detecting alterations in patients with a C9orf72 repeat expansion. We focused on the cerebellum, since key C9orf72-related pathologies are abundant in this neuroanatomical region, yet TDP-43 pathology and neuronal loss are minimal. Consistent with previous work, we showed a reduction in the expression of the C9orf72 gene and an elevation in homeobox genes, when comparing patients with the expansion to both patients without the C9orf72 repeat expansion and control subjects. Interestingly, we identified more than 1000 alternative splicing events, including 4 in genes previously associated with ALS and/or FTLD. We also found an increase of cryptic splicing in C9orf72 patients compared to patients without the expansion and controls. Furthermore, we demonstrated that the expression level of select RNA-binding proteins is associated with cryptic splice junction inclusion. Overall, this study explores the presence of widespread transcriptomic changes in the cerebellum, a region not confounded by severe neurodegeneration, in post-mortem tissue from C9orf72 patients.
Berufliche Qualifikation im Rettungsdienst – wofür ist eine Akademisierung von Rettungsdienstpersonal sinnvoll?
Authors: Gottschalk J. , Jerrentrup A. , Plöger B. , Orendt J. , Gnirke A.
Published: April 2024

Hintergrund

Bei vielen Berufen im Gesundheitswesen ist ein Trend zur Akademisierung erkennbar. In der neunten Stellungnahme und Empfehlung der Regierungskommission für eine moderne und bedarfsgerechte Krankenhausversorgung ist nun auch eine akademische Qualifikation für nichtärztliches Rettungsdienstpersonal empfohlen. Im Rahmen eines regelmäßigen Austauschs, der einmal jährlich in Präsenz und spätestens quartalsweise online stattfindet, diskutieren Geschäftsführer, Betriebsleiter, Bildungsverantwortliche und Ärztliche Leiter der Rettungsdienste des BRK (Bayerisches Rotes Kreuz) Kreisverband Regensburg, der DRK (Deutsches Rotes Kreuz) Rettungsdienst Mittelhessen gGmbH und der Rettungsdienst-Kooperation in Schleswig-Holstein (RKiSH) gGmbH die Fragestellung, ob und in welchen Bereichen eine Akademisierung im Rettungsdienst erforderlich und/oder sinnvoll ist.

Methoden

Es wurden die möglichen Anliegen von Hilfesuchenden identifiziert und versucht, diese, unter Berücksichtigung von medizinischen Zustandsbildern, in unterschiedliche Kategorien aufzuteilen. Anschließend konnte diesen Kategorien das benötigte Kompetenzprofil zugeordnet werden und dieses anschließend mit einer passenden Qualifikation besetzt werden. Konnte keine passende Qualifikation zugeordnet werden, wurden Inhalte definiert, die für eine neue Qualifikation erforderlich sind. Durch einen Blick in den Deutschen Qualifizierungsrahmen konnte die Zuordnung der Qualifikationen vorgenommen werden und der Bedarf eines Studiums festgestellt werden.

Ergebnisse

Vier Kategorien, Kategorie I – kritisch mit schnellem Interventionsbedarf –, Kategorie II – kritisch mit schneller Transportnotwendigkeit –, Kategorie III – dringliche Indikation – und Kategorie IV – unkritische Indikationen –, wurden identifiziert. Für die kritisch erkrankten oder verletzten Hilfesuchenden ist die derzeitige Qualifikation Notfallsanitäterin oder Notfallsanitäter geeignet, um selbstständig oder mit (tele-)notärztlicher Unterstützung die bestmögliche Versorgung zu gewährleisten. Für die Hilfesuchenden, die niederschwellige und unkritische Anliegen haben, ist derzeit keine geeignete berufliche Qualifikation vorhanden. Auch in Hinblick auf einen vorbeugenden Rettungsdienst ist hierfür eine neue Qualifikation zu entwickeln. Hierfür wurden erforderliche Kompetenzen festgestellt. Um diese zu erreichen, scheint eine akademische Qualifizierung notwendig zu sein.
Transforming online voting: a novel system utilizing blockchain and biometric verification for enhanced security, privacy, and transparency
Authors: Hossain Faruk Md Jobair , Alam Fazlul , Islam Mazharul , Rahman Akond
Published: April 2024

As a cornerstone of democratic governance, elections hold unparalleled significance, shaping a nation’s trajectory. However, the prevailing ballot-paper based voting systems continue to face trust issues among significant populations. As a result, e-Voting has emerged as an appealing alternative, with numerous countries opting for its implementation globally. While e-Voting systems offer several advantages, they also come with their own set of challenges. Even a minor vulnerability can lead to massive manipulations in voting results. In recent years, there have been efforts to revolutionize the e-Voting paradigm by harnessing the potential of emerging technologies such as biometrics and blockchain. This paper proposes a Internet-based voting that adopts blockchain technology and biometric identification techniques. We use biometric modalities, such as fingerprint and facial recognition, for voter authentication while leveraging Hyperledger Fabric framework as blockchain network and ensuring a secure, transparent, and tamper-evident voting record. We demonstrate the proposed system with 100 participants in a preset environment where we collect the biometrics data. The results indicate that 87% of participants successfully registered with biometrics, while 88% cast their votes with a combination of either voter ID and fingerprint or voter ID with facial recognition. Our findings suggest that the proposed system allows voters to access the system seamlessly and automate identity verification procedures while ensuring a secure, decentralized, and distributed database network that maintains transparency. Future research shall be carried out in collaboration with election officials and voters to improve the system in real-world scenarios.
Interactive remote electrical safety laboratory module in biomedical engineering education
Authors: Haj-Hosseini Neda , Jonasson Hanna , Stridsman Magnus , Carlsson Lars
Published: April 2024

To enable interactive remote education on electrical safety in biomedical engineering, a real-life problem-based laboratory module is proposed, implemented and evaluated. The laboratory module was implemented in a freestanding distance course in hospital safety for three consecutive years and was based on electrical safety for medical devices, where standard equipment existing in most hospitals could be used. The course participants were from a total of 42 geographical locations in or near Sweden. To allow a high level of interaction, especially among peer students, a graphical digital platform (Gather Town) was used. The digital platform was additionally used in two group work sessions. The experience of the participants in terms of usefulness and satisfaction was rated on a range of [-2, 2] using a van der Laan 5-point Likert-based acceptance scale questionnaire. The laboratory module overall was scored 4.1/5 by the participants (n = 29) in the final course assessments. The evaluation of the digital platform alone showed that in the first usage instance, the participants (n = 21) found the platform to be useful (0.54 ± 0.67) and satisfactory (0.37 ± 0.60). The participants’ experience of the digital platform improved when comparing two identical group work assignments so that ratings of usefulness and satisfaction were 1.11 ± 0.59 and 1 ± 0.71, respectively, after they had used it in the second group work session (n = 38). This study provides an instance of an interactive remote electrical safety laboratory module that is envisioned to contribute to further implementations of sustainable education in biomedical engineering.
The Role of Fiscal Policy — A Survey of Recent Empirical Findings
Authors: Le Vo Phuong Mai , Meenagh David , Minford Patrick
Published: April 2024

DSGE models based on New Keynesian principles, which have been extended to allow for banking, the zero lower bound on interest rates (ZLB), and varying price duration, can account well for recent macroeconomic behavior across a variety of economies. These models find that active fiscal policy can contribute to macroeconomic stability and welfare by reducing the frequency of hitting the ZLB. Fiscal policy can also share the stabilisation role with monetary policy, whose effectiveness under the ZLB is much reduced.
Estimating excess migration associated with tropical storms in the USA 1990–2010
Authors: Paglino Eugenio
Published: April 2024

Tropical storms are among the most devastating natural disasters in the USA. Climate change is projected to make them even more destructive, and the number of people and properties at risk has steadily increased over the past several decades. Migration is often seen by scholars as an adaptation strategy to reduce exposure to future natural disasters. However, studies of migration after tropical storms have led to inconsistent results and have not analyzed post-storm migration from the viewpoint of exposure to future events. This paper adopts an innovative approach to estimate “excess migration” associated with tropical storms using Bayesian hierarchical models, and decomposes migration by risk of exposure to natural disasters of the origin and destination to understand whether migrants move to safer areas or rather riskier ones. Findings indicate that excess migration after tropical storms is rare and generally fails to reduce the number of people at risk of experiencing future natural disasters. Only the most destructive tropical storms are associated with significant excess migration. Finally, findings further suggest that neither the amount of post-disaster assistance nor the socio-demographic characteristics of the affected counties are strongly associated with excess migration.
The Civic Identity of the Ethical Consumer
Authors: Roberts Jonathan , Chandra Gauri
Published: April 2024

Ethical consumerism describes market transactions where consumers’ preferences stretch beyond immediate self-interest to prosocial objectives. How such activities relate to more traditional forms of civic engagement (such as giving or activism) remains unclear; as a market-situated activity, ethical consumerism is often omitted from accounts of civic engagement or predicted to erode commitment to civic action. This paper reports findings from an empirical study of the civic identity of the ethical consumer. Using an online survey instrument, the study explores statistical relationships between individuals’ actual participation in ethical consumerism at three sites (Fairtrade, TOMS Shoes and (RED)) and the extent of individuals’ wider civic engagement—both philanthropic (giving, volunteering) and activist (campaigning). It finds evidence of a consistent civic identity that stretches across traditional civic engagement activities and ethical consumerism: the greater an individual’s civic engagement, the more likely they are to engage in ethical consumerism. The current analytic separation of ethical consumerism and civic engagement, therefore, does not capture the experience of individuals who are expanding their prosocial repertoire from the civic sphere to the market sphere; civic engagement cuts across sectors.
Atherosclerotic burden and cerebral small vessel disease: exploring the link through microvascular aging and cerebral microhemorrhages
Authors: Csiszar Anna , Ungvari Anna , Patai Roland , Gulej Rafal , Yabluchanskiy Andriy , Benyo Zoltan , Kovacs Illes , Sotonyi Peter , Kirkpartrick Angelia C. , Prodan Calin I. , Liotta Eric M. , Zhang Xin A. , Toth Peter , Tarantini Stefano , Sorond Farzaneh A. , Ungvari Zoltan
Published: April 2024

Cerebral microhemorrhages (CMHs, also known as cerebral microbleeds) are a critical but frequently underestimated aspect of cerebral small vessel disease (CSVD), bearing substantial clinical consequences. Detectable through sensitive neuroimaging techniques, CMHs reveal an extensive pathological landscape. They are prevalent in the aging population, with multiple CMHs often being observed in a given individual. CMHs are closely associated with accelerated cognitive decline and are increasingly recognized as key contributors to the pathogenesis of vascular cognitive impairment and dementia (VCID) and Alzheimer’s disease (AD). This review paper delves into the hypothesis that atherosclerosis, a prevalent age-related large vessel disease, extends its pathological influence into the cerebral microcirculation, thereby contributing to the development and progression of CSVD, with a specific focus on CMHs. We explore the concept of vascular aging as a continuum, bridging macrovascular pathologies like atherosclerosis with microvascular abnormalities characteristic of CSVD. We posit that the same risk factors precipitating accelerated aging in large vessels (i.e., atherogenesis), primarily through oxidative stress and inflammatory pathways, similarly instigate accelerated microvascular aging. Accelerated microvascular aging leads to increased microvascular fragility, which in turn predisposes to the formation of CMHs. The presence of hypertension and amyloid pathology further intensifies this process. We comprehensively overview the current body of evidence supporting this interconnected vascular hypothesis. Our review includes an examination of epidemiological data, which provides insights into the prevalence and impact of CMHs in the context of atherosclerosis and CSVD. Furthermore, we explore the shared mechanisms between large vessel aging, atherogenesis, microvascular aging, and CSVD, particularly focusing on how these intertwined processes contribute to the genesis of CMHs. By highlighting the role of vascular aging in the pathophysiology of CMHs, this review seeks to enhance the understanding of CSVD and its links to systemic vascular disorders. Our aim is to provide insights that could inform future therapeutic approaches and research directions in the realm of neurovascular health.
Synergies between recovery from work and restorative environments for sustainable development: an integrative theoretical perspective
Authors: Hilbert Micha , Binnewies Carmen , Berkemeyer Laura
Published: April 2024

In this theoretical article for Gruppe. Interaktion. Organisation. (GIO), we elaborate on the contribution of recovery from work research to the Sustainable Development Goals (SDGs). For this, we first briefly review theoretical and empirical knowledge on both recovery from work and restorative environments, and afterward we extend the existing framework on recovery from work by integrating physical environments. Second, we derive practical implications for organizations and policymakers and summarize the synergies of this theoretical integration for achieving the SDGs. In particular, we elaborate on reducing environmental demands and enhancing environmental resources, for example via biophilic design, as promising strategy for achieving the SDGs. We conclude with recommendations for future research on recovery from work and SDGs.
Replacing Animal Testing with Stem Cell-Organoids : Advantages and Limitations
Authors: Park Guiyoung , Rim Yeri Alice , Sohn Yeowon , Nam Yoojun , Ju Ji Hyeon
Published: April 2024

Various groups including animal protection organizations, medical organizations, research centers, and even federal agencies such as the U.S. Food and Drug Administration, are working to minimize animal use in scientific experiments. This movement primarily stems from animal welfare and ethical concerns. However, recent advances in technology and new studies in medicine have contributed to an increase in animal experiments throughout the years. With the rapid increase in animal testing, concerns arise including ethical issues, high cost, complex procedures, and potential inaccuracies.

Alternative solutions have recently been investigated to address the problems of animal testing. Some of these technologies are related to stem cell technologies, such as organ-on-a-chip, organoids, and induced pluripotent stem cell models. The aim of the review is to focus on stem cell related methodologies, such as organoids, that can serve as an alternative to animal testing and discuss its advantages and limitations, alongside regulatory considerations.

Although stem cell related methodologies has shortcomings, it has potential to replace animal testing. Achieving this requires further research on stem cells, with potential societal and technological benefits.

Graphical Abstract
Stairway to Heaven: LGBTQ+ Gatherings as Civil-Religious Rituals
Authors: Schwarzkopf Stefan , Just Sine Nørholm , Christensen Jannick Friis
Published: April 2024

This paper applies ritual theory to study public LGBTQ+ gatherings, including Pride parades, silent vigils, and commemorative litanies. The analysis of public LGBTQ+ rituals has often focussed on Pride parades and their carnivalistic exuberance. We call instead for more attention to the whole nexus of public rituals that this movement consists of, and we argue that these rituals are central to LGBTQ+ community building and meaning-making in this social movement. Using participant and non-participant observation, as well as publicly available data, the paper studies assembly forms, ritual scripts, symbolic interactions, sites, and objects that link the various public rituals within the LGBTQ+ movement. We find that, over the last five decades, these ritual elements have coalesced to provide members of the LGBTQ+ community access to the sphere of transcendence. Our findings suggest that this community might be slowly changing its character from social (protest) movement to becoming a viable civil religion.
Quality of life of individuals with serious mental illness and family caregivers
Authors: de Medina-Moragas Alejandro Jesús , Lima-Serrano Marta , Fernández-Fernández María José , Lima-Rodríguez Joaquín Salvador
Published: April 2024

The well-being and satisfaction of individuals with serious mental illnesses (SMI) and their family caregivers are less than desirable. Research on the quality of life (QoL) of individuals with SMI and their caregivers, including disorders other than schizophrenia, is limited. Thus, this study aimed to investigate the self-perception of QoL in patients with SMI and their family caregivers and the associated factors. This cross-sectional study was conducted in patients with SMI and their caregivers who completed self-assessment instruments to determine their QoL. Social support and burden in caregivers and symptomatology levels in individuals with SMI were assessed. The physical aspect of QoL in individuals with SMI was associated with employment status and symptom severity. The physical component of caregivers’ QoL was associated with kinship relationship, the presence of other family members with disabilities, social support, and age. The mental component was associated with global symptomatology and the diagnosis of major depression in individuals with SMI and caregiver burden in family members. In conclusion, these findings on correlated factors of QoL in individuals with SMI and their caregivers could be used in developing therapeutic interventions for mental health.

Plain summary

A significant number of people with serious mental health problems and their families often endure poor quality of life. However, research on how these individuals truly feel about their lives is limited. This study aimed to explore the perceptions of quality of life among individuals with serious mental health issues and their family caregivers in Spain. We sought to understand the personal sentiments of these individuals and their caregivers regarding their quality of life and the factors that influence it. Our findings indicate that job status, symptoms of the illness, and family relationships play crucial roles in how these individuals view their quality of life. Additionally, caregivers' age, support they receive, and the challenges they face in their families can influence their feelings. This implies that, to enhance their lives, it is crucial to consider these factors and provide appropriate support.
The Role of Cognitive Reserve in Protecting Cerebellar Volumes of Older Adults with mild Cognitive Impairment
Authors: Devita Maria , Debiasi Giulia , Anglani Mariagiulia , Ceolin Chiara , Mazzonetto Ilaria , Begliomini Chiara , Cauzzo Simone , Raffaelli Cecilia , Lazzarin Alessandro , Ravelli Adele , Bordignon Alessandra , De Rui Marina , Sergi Giuseppe , Bertoldo Alessandra , Mapelli Daniela , Coin Alessandra
Published: April 2024

The present study aims to investigate the relationship between cerebellar volumes and cognitive reserve in individuals with Mild Cognitive Impairment (MCI). A description of proxies of cerebellar cognitive reserve in terms of different volumes across lobules is also provided. 36 individuals with MCI underwent neuropsychological (MoCA, MMSE, Clock test, CRIq) assessment and neuroimaging acquisition with magnetic resonance imaging at 3 T. Simple linear correlations were applied between cerebellar volumes and cognitive measures. Multiple linear regression models were then used to estimate standardized regression coefficients and 95% confidence intervals. Simple linear correlations between cerebellar lobules volumes and cognitive features highlighted a significant association between CRIq_Working activity and specific motor cerebellar volumes: Left_V (ρ = 0.40, p = 0.02), Right_V (r = 0.42, p = 0.002), Vermis_VIIIb (ρ = 0.47, p = 0.003), Left_X (ρ = -0.46, p = 0.002) and Vermis_X (r = 0.35, p = 0.03). Furthermore, CRIq_Working activity scores correlated with certain cerebellar lobules implicated in cognition: Left_Crus_II, Vermis VIIb, Left_IX. MMSE was associated only with the Right_VIIB volume (r = 0.35, p = 0.02), while Clock Drawing Test scores correlated with both Left_Crus_I and Right_Crus_I (r = -0.42 and r = 0.42, p = 0.02, respectively). This study suggests that a higher cognitive reserve is associated with specific cerebellar lobule volumes and that Working activity may play a predominant role in this association. These findings contribute to the understanding of the relationship between cerebellar volumes and cognitive reserve, highlighting the potential modulatory role of Working activity on cerebellum response to cognitive decline.

Graphical Abstract
What we already know about corporate digital responsibility in IS research: A review and conceptualization of potential CDR activities
Authors: Carl K. Valerie , Hinz Oliver
Published: April 2024

Advances in new technologies affect private and professional lives alike, posing new opportunities and threats for companies, consumers, and society. In this context, the concept of corporate digital responsibility (CDR) gains traction enabling technologies benefitting humanity while exceeding mere technology advancements. Yet, theory and practice still lack a systematic in-depth understanding of the concept’s scope up to concrete activities. The aim of this paper is to enable a more concrete and deeper understanding of the concept scope by drawing on available knowledge in the thematically related discipline of information systems (IS) in general and electronic markets in particular. The study employs an extended systematic literature review to aggregate prior knowledge in this research domain relatable to the concept of CDR and to develop an in-depth classification of potential CDR activities inductively according to ten dimensions, corresponding sub-dimensions, and respective fields of action. This contributes to the overarching goal to develop the conceptualization of CDR and to anchor the concept in the context of electronic markets, thereby fostering human and social value creation.
SLC35A2 expression is associated with HER2 expression in breast cancer
Authors: Wang Yiran , Peng Xiaobo , Wu Meihong , Wang Bin , Chen Tianran , Zhan Xianbao
Published: April 2024

The role of SLC35A2 in breast cancer remains poorly understood, with limited available information on its significance. This study aimed to investigate the expression of SLC35A2 and clinicopathological variables in breast cancer patients. Immunohistochemical analysis of SLC35A2 protein was conductedon 40 adjacent non-neoplastic tissues and 320 breast cancer tissues. The study also assesed the association between SLC35A2 expression and breast cancer clinicopathological features of breast cancer, as well as its impact on overall survival. In comparison to adjacent non-neoplastic tissues, a significantly higher expression of SLC35A2 was observed in breast cancer tissues (P = 0.020), and this expression was found to be independently correlated with HER2 positivity (P = 0.001). Survival analysis indicated that patients with low SLC35A2 expression had a more favorable prognosis in HER2-positive subtype breast cancer (P = 0.017). These results suggest that SLC35A2 is overexpressed in breast cancer tissues compared to adjacent non-neoplastic tissues and may serve as a potential prognostic marker for HER2-positive subtype breast cancer. Furthermore, breast cancer patients with the HER2 positive subtype who exhibited decreased levels of SLC35A2 expression demonstrated improved long-term prognostic outcomes.
Are Biology Experts and Novices Function Pluralists?
Authors: Roberts Andrew J. , Bourrat Pierrick
Published: April 2024

Philosophers have proposed many accounts of biological function. A coarse-grained distinction can be made between backward-looking views, which emphasise historical contributions to fitness, and forward-looking views, which emphasise the current contribution to fitness or role of a biological component within some larger system. These two views are often framed as being incompatible and conflicting with one another. The emerging field of synthetic biology, which involves applying engineering principles to the design and construction of biological systems, complicates things further by adding intentional design as a source of function. In the current study we explored how biology experts and novices think about function in the context of single-celled, multi-celled, and synthetic organisms. We also explored the extent to which each group were function pluralists, and if they were function pluralists, which accounts of function tended to be endorsed together. The results showed a surprising degree of similarity between experts and novices in most contexts, although certain differences were apparent. Most surprisingly, we found evidence not only of function pluralism in both groups, but pluralism between backward-looking and forward-looking accounts. We discuss these findings in the context of the philosophical debate on function and consider the practical implications for public acceptance of synthetic biology. First, we argue that philosophers of biology should re-examine the purported incompatibility between accounts of function. Second, we argue that due to the introduction of an intentional aetiology in synthetic biology, there may be an inherent conflict between the views of experts and novices when thinking about synthetic biology.
Building stewardship capacity through fishers’ knowledge and advocacy in fisheries management: a case study from Southeast Alaska
Authors: Scalisi Emma D. , Beaudreau Anne H. , Mason Ellie
Published: April 2024

Local environmental stewardship supports resilience of social-ecological systems through a wide range of actions that benefit both environmental and human wellbeing. Stewardship actions of harvesters have been recognized as an important component in building adaptive capacity of coastal fisheries undergoing change. In Southeast Alaska, where commercial fishing plays a key role in cultures and economies, concerns for local fisheries have arisen from declines in salmon returns, high price variability, and barriers to participation, among other issues. Here, we aimed to understand existing and potential pathways for stewardship actions of small-boat commercial fishers in Juneau, Alaska. We conducted semi-structured interviews with 22 commercial fishers, agency staff, and leaders of seafood associations to document fisher-led stewardship actions and ways that small-boat commercial fishers engage formally and informally with local management, explore the role of fishery management agencies in facilitating collaboration and communication with fishers in the Juneau area, and understand local perspectives on how the stewardship capacities of the fishery system can be better supported. We found that multiple pathways for stewardship exist in commercial salmon and shellfish fisheries, including formal and informal interactions with state fishery management staff and decision-makers, participation in fishing associations and advocacy organizations, knowledge sharing among fishers, and taking personal conservation actions to care for fisheries. We identified areas of relatively low social, financial, and institutional capital that may limit the effectiveness of these stewardship actions. Our findings highlight diverse perspectives of fishery participants on how these stewardship actions might be better supported through policy, advocacy, and collaboration.
Seismic Bearing Capacity of a Footing on Sloping Frictional Soil
Authors: Garzón-Roca Julio , Melentijevic Svetlana
Published: April 2024

This study presents the analysis of surficial strip footing on sloping frictional ground for an easy estimation of its seismic bearing capacity (by means of a seismic slope coefficient) to be used in conjunction with any other analytical solution provided for the static case. The influence of the slope angle and height, proximity of the slope to the crest, and value of the pseudo-static seismic coefficient is presented. A parametric study performed for the range of these geometrical and geotechnical parameters is conducted by the finite element method, also presenting the analysis of failure modes. The results are summarized in the form of non-dimensional charts that could be easily used for the estimation of the seismic bearing capacity by practitioners. An example of the application of charts is presented. It can be concluded that there is no influence of the sloping ground when the distance of the footing is greater than four times the width. For the horizontal seismic coefficients greater than 0.3 g, the shallow foundations should not be placed near the slope.
Structure-property relationship and emerging applications of nano- and micro-sized fillers reinforced sialon composites: a review
Authors: Ogunbiyi Olugbenga , Jamiru Tamba , Adekoya Gbolahan Joseph , Rominiyi Azeez Lawan
Published: April 2024

Oxonitridoaluminosilicates (SiAlON) are renowned in advanced ceramics for their exceptional properties: high temperature stability, excellent oxidation resistance, and good wear resistance. Incorporating micro- and nano-sized fillers into SiAlON matrices enhances their properties, yielding SiAlON composite materials with superior mechanical, tribological, and thermal characteristics. This review examines fabrication techniques for producing SiAlON micro/nanocomposites and the structure-property relationships governing their performance across different phase compositions (β, α, X, and O-phases). A comprehensive literature review scrutinized fabrication techniques and structure-property relationships from various databases and scholarly articles. Although SiAlON composites with micro/nano inclusions hold promise across applications, understanding their fabrication processes, structure-property relationships, and potential applications in different fields is crucial. The review highlights diverse fabrication techniques for SiAlON micro/nanocomposites and provides insights into their structure-property relationships. Additionally, emerging applications in structural domains, cutting tools, coatings, corrosion protection, solar cells, LEDs, biomedical realms, and filtration membranes are discussed. This review is a valuable resource for researchers and engineers interested in designing SiAlON products tailored for sophisticated applications. It emphasizes understanding fabrication processes and structure-property relationships to unlock SiAlON-based materials' full potential across industries.
Long-term effects of biochar one-off application on soil physicochemical properties, salt concentration, nutrient availability, enzyme activity, and rice yield of highly saline-alkali paddy soils: based on a 6-year field experiment
Authors: Jin Feng , Piao Junlong , Miao Shihao , Che Weikang , Li Xiang , Li Xuebin , Shiraiwa Tatsuhiko , Tanaka Tomoyuki , Taniyoshi Kazuki , Hua Shuang , Lan Yu
Published: April 2024

Biochar application can alleviate the adverse effects of saline-alkali stress on crops. However, the long-term effects of one-off biochar application on soil physicochemical properties, salt concentration, nutrient availability, soil enzyme activities, and rice yield under highly saline-alkali paddy soils remain unclear. Here, a 6-year paddy field study was conducted in a saline-alkali paddy field using two nitrogen application levels (0 and 225 kg ha−1) and four biochar application rates [0 (T0), 1.5% (T1.5), 3.0% (T3.0), and 4.5% (T4.5) biochar, w/w]. The results showed that compared with T0, the bulk density (BD) under T1.5, T3.0, and T4.5 treatments significantly decreased by 11.21%, 16.33%, and 25.57%, while total porosity (Tp) and saturated hydraulic conductivity (Ks) increased by 19.15–27.34% and 3217.78–5539.83%, respectively. Biochar consistently improved soil macro-aggregates, mean weight diameter (MWD), and the percentage of water-stable aggregates (PWSA) over the years. Additionally, one-off application of biochar continuously reduced the soil Na+ concentration, Na+/K+ ratio, Na+/Ca2+ ratio, saturated paste extract (ECe), exchangeable sodium percentage (ESP), and sodium adsorption ratio (SARe). However, it reduced the pH in 2021 and 2022 only. It enhanced the concentration of K+, Ca2+, Mg2+, and cation exchange capacity (CEC) over the 6-year study, indicating its longer-term positive impact. Furthermore, the one-off biochar application, especially under high application rate treatments (T3.0 and T4.5), significantly and continuously improved nutrient availability and soil enzyme activities. However, alkali-hydrolysable nitrogen (AN) decreased in the initial year of biochar application. The grain yield of T1.5, T3.0, and T4.5 surpassed that of T0 by 116.38%, 141.24%, and 145.20%, respectively. Notably, the rice yield reached its peak with the treatment of 3.0% (w/w) in all 6 years of study period. These findings offered new perspectives on repairing and improving soil quality and production ability of highly saline-alkali paddy soils.

Graphical Abstract
Virtual design on the heat pump refrigeration cycle: challenges and approaches
Authors: Hwang Yoon Jei , Park Noma
Published: April 2024

Virtual product design (VPD) of the refrigeration cycle has long been a major subject of many engineers and manufacturers. Issues should be the question of how simulation gets close to the real world in virtual ways. It is especially true when we consider variable refrigerant flow (VRF) heat pumps, having various types of indoor unit combinations, long and complicated piping configurations, and simultaneous cooling and heating functions under extreme weather conditions. In this regard, model-based systems engineering (MBSE) or model-based design (MBD) guides a methodology to make a virtual model easily. Now, there are plenty of engineering platforms and tools to make a strong simulation model, which provides interfacing technology among multiple physics, different dimensions, and codes in different languages. In the study, the authors share their experience in the virtual design for a VRF heat pump system including the architecture, multiple physics, and the connection with the control SW. Modelica, an acausal and object-oriented modeling language, constructs the backbone of the model to describe the dynamic behavior of refrigerants and to combine external components in the form of functional mock-up units (FMUs). The developed virtual model is validated against measured data, showing it can reproduce all the essential physics of interest both in qualitative and quantitative ways.
Kant on Pleasure and Judgment
Authors: Rueger Alexander
Published: April 2024

Were there interactions between the development of Kant's aesthetics and the development of his moral philosophy? How did Kant view pleasure and displeasure and what role did they play in the formation of his system of the faculties? In this book, Alexander Rueger situates Kant's account of pleasure and displeasure in its eighteenth-century context, with special attention to Leibniz, Wolff, Crusius, and Mendelssohn. He traces the development of Kant's views on pleasure from the 1770s to his Critique of Aesthetic Judgment in 1790, and shows that throughout, Kant understood pleasure as the satisfaction of faculty interests. The significance of this theory for the completion of Kant's critical system in the third Critique is discussed in detail. Rueger's study illuminates both the role of pleasure and displeasure in Kant's thought, and their important connections to the power of judgment.