bluuebunny/crossref_metadata_2025 huggingface dataset:
Modified Permanent Magnet Synchronous Generators for Using in Energy Supply System for Autonomous Consumer
Authors: Kotin Denis , Ivanov Ilya , Shtukkert Sofya
Published: November 2021

In this paper, the possibility of using synchronous generators with magnetoelectric excitation for the autonomous consumers’ supply with the use of renewable energy sources is considered. To eliminate a number of the disadvantages associated with the difficulty of energy-efficient regulation of the generated parameters, such as the generated current and voltage, the use of modified multi-winding synchronous generators with permanent magnets is proposed. It allows solving the problem of controlling this type of generator. In addition, the use of this type of generator helps to increase the amount of energy generated. The authors have proposed several synchronous generators with permanent magnets of various supply network architectures: single-phase, two-phase and traditional three-phase types. This will simplify the design of architecture for several cases of consumer power supply systems. It will also help to eliminate the need to organize a balanced distribution of loads in phases to prevent accidents, damage and/or disabling of consumers themselves. Here, we considered mathematical descriptions of several types of generators that differ in their assembling, in particular, the number of phases (one-, two- and three-phase generators), the number of pairs of permanent magnet poles on the rotor, and the method of switching the generator windings among themselves. Using the developed mathematical descriptions that describe the operation of every single winding of the generator, their mathematical models were developed in the SimInTech mathematical modeling environment. The results of the mathematical modeling of these generators were presented; their interpretation for use with renewable energy sources was made; and the methods of using these generators were described. The developed mathematical descriptions of synchronous generators with permanent magnets can be used for further study of their operation. It can also help for the development of control systems and power systems for micro-grid energy complexes that use renewable energy sources to increase the energy efficiency of micro-grid systems.
Stakeholders’ Risk Perceptions of Decarbonised Energy System: Insights into Patterns of Behaviour
Authors: Karimi Farid
Published: November 2021

According to EU goals and the Paris Agreement, an urgent need exists for reducing CO2 emissions while still securing energy supply. Thus, the timely deployment of carbon capture and storage (CCS) is seemingly unavoidable, especially for the cement and steel industries. However, diverse perceptions of CCS among stakeholders such as experts, politicians, and laypeople exist that could hinder the deployment of the technology. Hence, it is worthwhile to recognise these diverse perceptions and their roots. In the studies on risk perceptions, the emphasis has been mostly on the public, as well as factors that influence the public, such as knowledge dissemination and trust. Although these are crucial elements, they are not enough to explain the complexity of risk perceptions. In contrast to the mainstream research, this paper hypothesises that both laypeople and experts are affected by common cultural denominators, therefore, might have similar patterns of risk perceptions. This research suggests a framework that explains the role of societal culture in risk governance, arguing that thrifty, uncertainty avoidant, hierarchical societies tend to have a higher risk perception of CCS. This study is based on a synthesis of the earlier research, an extensive literature review, and an analysis of interviews data.
An Enhanced Cuckoo Search Algorithm Fitting for Photovoltaic Systems’ Global Maximum Power Point Tracking under Partial Shading Conditions
Authors: Ali Ehab Mohamed , Abdelsalam Ahmed K. , Youssef Karim H. , Hossam-Eldin Ahmed A.
Published: November 2021

The output power against voltage curve of the photovoltaic system changes its characteristics under partial shading conditions because of using bypass diodes. These bypass diodes are connected across the PV modules inside the string to avoid hotspot formation in the shaded PV modules. Therefore, the output curve has multiple power peaks with only one Global Max Power Point. The classical Maximum Power Point Tracking algorithms may fail to track that Global Max Power. Several soft computing algorithms have been proposed to improve tracking efficiency with different optimization principles. In this paper, an Improved Cuckoo Search Algorithm has been proposed to increase the tracking speed with minimum output power oscillation. The proposed algorithm avoids spreading the initial particles among the whole curve to predict shading pattern, but it reduces the exploration area after each iteration to compensate for the algorithm’s randomness. The proposed algorithm was compared with other methods by simulation using MATLAB/Simulink program and with practical experiments under the same operating conditions. The comparison showed that the proposed algorithm overcomes the other methods’ drawbacks and concurrently minimizes the convergence time, power oscillation, and system power losses.
Optimisation of the Operation of an Industrial Power Plant under Steam Demand Uncertainty
Authors: Rahimi-Adli Keivan , Leo Egidio , Beisheim Benedikt , Engell Sebastian
Published: November 2021

The operation of on-site power plants in the chemical industry is typically determined by the steam demand of the production plants. This demand is uncertain due to deviations from the production plan and fluctuations in the operation of the plants. The steam demand uncertainty can result in an inefficient operation of the power plant due to a surplus or deficiency of steam that is needed to balance the steam network. In this contribution, it is proposed to use two-stage stochastic programming on a moving horizon to cope with the uncertainty. In each iteration of the moving horizon scheme, the model parameters are updated according to the new information acquired from the plants and the optimisation is re-executed. Hedging against steam demand uncertainty results in a reduction of the fuel consumption and a more economic generation of electric power, which can result in significant savings in the operating cost of the power plant. Moreover, unplanned load reductions due to lack of steam can be avoided. The application of the new approach is demonstrated for the on-site power plant of INEOS in Köln, and significant savings are reported in exemplary simulations.
Geochemical Characteristics of Expelled and Residual Oil from Artificial Thermal Maturation of an Early Permian Tasmanite Shale, Australia
Authors: Xie Xiaomin , Wang Ye , Lin Jingwen , Wu Fenting , Zhang Lei , Liu Yuming , Hu Xu
Published: November 2021

Lipid biomarkers play an important role in defining oil-source rock correlations. A fundamental assumption is that composition (or ratios) of biomarkers in oil is not significantly different from that in bitumen in the source rock. In order to compare the geochemical characteristics of expelled oil and residual oil, a Permian Tasmanite oil shale was used for an artificial maturation experiment to simulate the oil generation period. The results show that the Tasmanite oil shale generated high amounts of hydrocarbons (731 mg HC/g TOC) at low maturation temperatures (340 °C). The hydrocarbon (HC) group compositions are different between the expelled oil (with more aromatic HC and saturated HC) and the residual oil (with more resin fraction and asphaltene). The Pr/Ph ratio (up to 4.01) of the expelled hydrocarbons was much higher than that in residual oil (<1.0). Maturity-related biomarkers Ts/(Ts + Tm), and αααC29-20S/(20S + 20R) and C29-αββ/(ααα + αββ), also showed complicated variations with pyrolysis temperature, especially at post peak oil generation. C27-, C28-, and C29- sterane distributions showed variations with pyrolysis temperature. Therefore, without considering the influence of maturity on the abundance of compounds, either source, maturity and/or organic matter type from the chemical characteristics may not be correct.
Microcrack Porosity Estimation Based on Rock Physics Templates: A Case Study in Sichuan Basin, China
Authors: Ruan Chuantong , Ba Jing , Carcione José M. , Chen Tiansheng , He Runfa
Published: November 2021

Low porosity-permeability structures and microcracks, where gas is produced, are the main characteristics of tight sandstone gas reservoirs in the Sichuan Basin, China. In this work, an analysis of amplitude variation with offset (AVO) is performed. Based on the experimental and log data, sensitivity analysis is performed to sort out the rock physics attributes sensitive to microcrack and total porosities. The Biot–Rayleigh poroelasticity theory describes the complexity of the rock and yields the seismic properties, such as Poisson’s ratio and P-wave impedance, which are used to build rock-physics templates calibrated with ultrasonic data at varying effective pressures. The templates are then applied to seismic data of the Xujiahe formation to estimate the total and microcrack porosities, indicating that the results are consistent with actual gas production reports.
Effect of Metal Additives in the Bed on the Performance Parameters of an Adsorption Chiller with Desalination Function
Authors: Sztekler Karol , Kalawa Wojciech , Mika Łukasz , Sowa Marcin
Published: November 2021

Adsorption chillers with desalination functionality, being devices characterised by very low electricity consumption, provide an alternative to conventional sources of cooling and water. The option of desalinating water means that the use of a single device enables obtaining two useful products. Adsorption chillers are not widely used at present. due to their low performance characteristics; these are, however, constantly being improved. This paper presents a verification of the possibility of increasing the cooling coefficient of performance (COP) and specific cooling power (SCP) of a laboratory adsorption chiller by optimising the length of cycle times and using a copper additive to silica gel with a mass fraction of 15% to increase heat transport in the bed. The choice of copper among other considered additives was determined by the conclusions from the research on the sorption kinetics of various mixtures, price and availability, and a high thermal conductivity. The device was operated in a two-bed mode aimed at producing cooling. The adsorbate was distilled water. The results were compared with those obtained under similar conditions when the beds were only filled with silica gel. As a result of the testing, it was found that the use of the copper additive with the sorbent increased both the COP and SCP. The tests were performed for different cycle times, of 100, 200, 300 and 600 s. With increasing cycle time COP also increased. In contrast, the specific cooling power increased only up to a certain point, whereafter its value decreased.
Egalitarian Kinetic Models: Concepts and Results
Authors: Constales Denis , Yablonsky Gregory , Xi Yiming , Marin Guy
Published: November 2021

In this paper, two main ideas of chemical kinetics are distinguished, i.e., a hierarchy and commensuration. A new class of chemical kinetic models is proposed and defined, i.e., egalitarian kinetic models (EKM). Contrary to hierarchical kinetic models (HKM), for the models of the EKM class, all kinetic coefficients are equal. Analysis of EKM models for some complex chemical reactions is performed for sequences of irreversible reactions. Analytic expressions for acyclic and cyclic mechanisms of egalitarian kinetics are obtained. Perspectives on the application of egalitarian models for reversible reactions are discussed. All analytical results are illustrated by examples.
Peter IV of Aragon (1336–1387)
Authors: Serrano-Coll Marta
Published: November 2021

Peter IV king of Aragón (1336–1387). He was the seventh king of the Crown of Aragon, and father of Juan I (1387–1396) and Martín I (1396–1410), the last members of the dynasty to take the throne. When Martín died, the Trastámara branch occupied the throne of the kingdom. Peter IV was dazzling in his ability to use art as a tool of authority and sovereignty. With the aim of exalting the dynasty, he patronised various enterprises, among the most important of which was the abbey of Santa Maria de Poblet, which he intended to be a burial place for himself and his successors, a wish that was fulfilled, without exception, down to Juan II, the predecessor of the Catholic Monarchs. A perfectionist and zealot, he endowed important religious events with profound political significance, and promoted works of great symbolism such as the genealogy of the new saló del tinell, or the ordinacions de la casa i cort, to which he added an appendix establishing how the kings of Aragon were to be crowned.
First Field Record of the Tropical Red-Banded Thrips Selenothrips rubrocinctus (Thripidae: Panchaetothripinae) in Europe
Authors: Taddei Andrea , Vono Gregorio , Vierbergen Gijsbertus , Wojnar Andrea , Zugno Matteo , Marullo Rita
Published: November 2021

Red-banded thrips Selenothrips rubrocinctus is a polyphagous pest widely distributed in tropical and subtropical regions. Various fruit trees such as cacao, cashew, mango, avocado, and guava in certain habitats are attacked. This is the first report of the spontaneous occurrence of outdoor populations of this species of thrips in Europe. This species has been found in northern Italy on Liquidambar styraciflua, Carpinus betulus, and other ornamental forest species in urban areas. Barcode sequences of the Italian specimens were obtained.
Experimental Investigations and Numerical Simulations of the Vibrational Performance of Wood Truss Joist Floors with Strongbacks
Authors: Shen Yinlan , Zhou Haibin , Xue Shuo , Yan Xingchen , Si Jiahao , Guan Cheng
Published: November 2021

This paper provides an experimental study and computer modeling analysis of vibration performance of full-scale wood truss joist floors, related to the static deflection and vibration mode/frequency and single-person-induced vibration. The vibration behavior of full-scale truss joist floors was investigated and the influences of the strongbacks on the vibration behavior were assessed. The results showed that the simulated predictions agreed well with the measured results. Strongbacks do not significantly affect the fundamental frequency of the truss joist floors but influence the second and third modal frequencies. The use of strongback rows at mid-span effectively decreased the maximum deformation of point loading at floor center. The effect of adding strongbacks at one-third of each span on decreasing maximum deformation at the floor center was minimal. The case of walking parallel to the joist produced higher acceleration response at the floor center than that of walking perpendicular to the joist. The closer the placements of strongbacks were to the mid-span, the more significant reduction of the vibration at floor center was. Two strongback rows at mid-span performed the best effect on reduction of vibration response at floor center. However, the use of strongbacks had limits of reduction peak acceleration of the sheathing between the joists. The study provides a valuable guide for future vibration serviceability study and design optimization of wood truss joist floors.
Assessment and Distribution of Damages Caused by the Trunk-Boring Insects Coraebus undatus (Fabricius) (Coleoptera: Buprestidae) and Reticulitermes grassei Clément (Blattodea: Rhinotermitidae) in Mediterranean Restored Cork-Oak Forests
Authors: Cárdenas Ana M. , Toledo Dafne , Gallardo Patricia , Guerrero-Casado José
Published: November 2021

This work assesses damage caused by Coraebus undatus (Fabricius) (Coleoptera: Buprestidae) and Reticulitermes grassei Clément (Blattodea: Rhinotermitidae) in managed cork oak forests from the southern Iberian Peninsula. Lesions were diagnosed and quantified in relation to the following features: height and orientation in the trunk, diameter at breast height, solar exposure, understory presence and orography. The distribution patterns of lesions in the study area across 12 plots and in the trunk of the trees were also analyzed. The study was performed in “Sa de Hornachuelos” Natural Park (Córdoba, Spain) and the research area encompassed 12 environmentally-restored sampling plots. Data were recorded from 2007 to 2014, with yearly sampling from late June to mid-September, corresponding to the cork extraction period, since lesions caused by these insects are well distinguishable promptly after bark removal. The results reveal that C. undatus has low population levels and a non-uniform distribution pattern in the study area as well as in the trunk of the tree. It shows preference for medium height but not by any trunk orientation. R. grassei also shows low infestation levels and a preference to affect the trunk’s base. Comparatively, C. undatus showed higher infestation levels than R. grassei. The location of damage was also different, since galleries made by C. undatus predominated at intermediate trunk heights while those of R. grassei were more frequent at lower heights. Our results further showed a low co-occurrence of both species in the same tree trunks, which could be explained in terms of overlapping in the distribution areas of both species. These results provide background information that will enable natural resources managers to detect changes and trends of these species and inform future management decisions.
Tree Diversity and Soil Characteristics in a Tea–Forest Interface in Southwest Sri Lanka
Authors: Geekiyanage Nalaka , Rathnayaka Srimal , Gamage Sriyani , Sandamali Adikari Appuhamilage Dulanjala , Nanayakkara Shamodi , Duminda Don Menige Sudesh , Gunatilleke Savitri , Gunatilleke Nimal
Published: November 2021

Fragmented and degraded ecosystems should be restored to ensure the biological connectivity among fragmented forest landscapes. The tropical rainforests of Southwestern Sri Lanka are highly degraded and fragmented due to plantation agriculture and human settlements. However, the high spatial variation in environmental factors and ecosystem functions challenge the success rate of restoration interventions. The aim of this study was to assess the vegetation composition and stand structure in relation to the spatial variation in key soil physicochemical parameters in the Endane Biodiversity Corridor that links peripheral forest reserve to the Sinharaja Rainforest Complex (SRC). The site that extends over 24 ha was classified into five land-use categories (productive tea lands, marginal tea lands, scrub—abandoned three years ago, and two woodlands—abandoned 15 years ago) in which the vegetation composition, stand structure, and physicochemical parameters of soil were assessed and mapped. Results revealed that the Shannon diversity index in the scrub and the woodlands were higher than in the tea lands. The diversity among the secondary forest patches was similar. However, with a mean record of 14 species, the species richness was high in sites close to the SRC. In comparison to the SRC (358 Mg ha−1), there was a substantial potential to sequester more carbon in the restoration sites (12–108 Mg ha−1). While explaining 31% of abundance and species distribution, the ordination results revealed a close relationship of the soil parameters to vegetation composition and species abundance. The calculated coefficient variation values for soil parameters (TN, EC, Av.P, Ex.K, OC, and BD) were beyond 12%, indicating high or moderate soil spatial variability among the land use categories. Coefficient of variation for soil pH was estimated to be 9%, revealing low soil spatial variability among the land use categories. The maps of these soil parameters corresponded with the type of land use and fertilizer application to tea fields. The highest and the lowest total N contents were observed in the scrub and woodlands, respectively, which appears to be mediated by the relative composition of N-fixing trees between the two groups. Our results facilitate effective matching of sites to species for restoration of the Endane Biodiversity Corridor that may be replicated in similar restoration contexts in tropical Asia.
Family Forest Owners’ Expectations and Perceptions of Service Quality in Timber Transactions in Sweden
Authors: Kronholm Thomas , Staal Wästerlund Dianne
Published: November 2021

In Sweden, 59% of the annual gross felling takes place in forests owned by family forest owners (FFOs). Forest companies conduct thousands of timber transactions with FFOs each year, and, most often, harvesting services are provided to them as part of the deal. Delivering services that meet the FFOs’ expectations of quality is important for any organization that wants FFOs to be loyal suppliers. The objectives of this study are to clarify FFOs’ service quality expectations in timber transactions, show how well forest companies meet these expectations, and identify factors that may influence FFOs’ quality assessments. Data were collected through a survey sent out to 973 FFOs, with a response rate of 43% (n = 418). The results show that, on average, FFOs perceived that the quality of the services delivered in relation to their latest timber transaction met their expectations on 2 out of 14 quality features: modern equipment (e.g., forest machines) and staff’s courtesy towards the FFO. The study concludes that skilled and service-minded employees are highly important for maintaining good relationships with FFOs and that forest companies may have a lot to gain by improving communication and taking the interests of the FFOs into greater consideration.
Representing and Validating Cultural Heritage Knowledge Graphs in CIDOC-CRM Ontology
Authors: Faraj Ghazal , Micsik András
Published: November 2021

In order to unify access to multiple heterogeneous sources of cultural heritage data, many datasets were mapped to the CIDOC-CRM ontology. CIDOC-CRM provides a formal structure and definitions for most cultural heritage concepts and their relationships. The COURAGE project includes historic data concerning people, organizations, cultural heritage collections, and collection items covering the period between 1950 and 1990. Therefore, CIDOC-CRM seemed the optimal choice for describing COURAGE entities, improving knowledge sharing, and facilitating the COURAGE dataset unification with other datasets. This paper introduces the results of translating the COURAGE dataset to CIDOC-CRM semantically. This mapping was implemented automatically according to predefined mapping rules. Several SPARQL queries were applied to validate the migration process manually. In addition, multiple SHACL shapes were conducted to validate the data and mapping models.
Aerodynamic Study of a NACA 64418 Rectangular Wing under Forced Pitching Motions
Authors: Gkiolas Dimitris , Mathioulakis Dimitrios
Published: November 2021

The aerodynamic behavior of a pitching NACA 64418 rectangular wing was experimentally studied in a subsonic wind tunnel. The wing had a chord c = 0.5 m, a span which covered the distance between the two parallel tunnel walls and an axis of rotation 0.35 c far from the leading edge. Based on pressure distribution and flow visualization, intermittent flow separation (double stall) was revealed near the leading edge suction side when the wing was stationary, at angles higher than 17° and Re = 0.5 × 106. Under pitching oscillations, aerodynamic loads were calculated by integrating the output data of fast responding surface pressure transducers for various mean angles of attack (αm (max) = 15°), reduced frequencies (kmax = 0.2) and angle amplitudes Δα in the interval [2°, 8°]. The impact of the above parameters up to Re = 0.75 × 106 on the cycle-averaged lift and pitching moment loops is discussed and the cycle aerodynamic damping coefficient is calculated. Moreover, the boundaries of the above parameters are defined for the case that energy is transferred from the flow to the wing (negative aerodynamic damping coefficient), indicating the conditions under which aeroelastic instabilities are probable to occur.
Alternative Lengthening of Telomeres: Lessons to Be Learned from Telomeric DNA Double-Strand Break Repair
Authors: Kent Thomas , Clynes David
Published: November 2021

The study of the molecular pathways underlying cancer has given us important insights into how breaks in our DNA are repaired and the dire consequences that can occur when these processes are perturbed. Extensive research over the past 20 years has shown that the key molecular event underpinning a subset of cancers involves the deregulated repair of DNA double-strand breaks (DSBs) at telomeres, which in turn leads to telomere lengthening and the potential for replicative immortality. Here we discuss, in-depth, recent major breakthroughs in our understanding of the mechanisms underpinning this pathway known as the alternative lengthening of telomeres (ALT). We explore how this gives us important insights into how DSB repair at telomeres is regulated, with relevance to the cell-cycle-dependent regulation of repair, repair of stalled replication forks and the spatial regulation of DSB repair.
Genomic Signatures of Domestication Selection in the Australasian Snapper (Chrysophrys auratus)
Authors: Baesjou Jean-Paul , Wellenreuther Maren
Published: November 2021

Domestication of teleost fish is a recent development, and in most cases started less than 50 years ago. Shedding light on the genomic changes in key economic traits during the domestication process can provide crucial insights into the evolutionary processes involved and help inform selective breeding programmes. Here we report on the recent domestication of a native marine teleost species in New Zealand, the Australasian snapper (Chrysophrys auratus). Specifically, we use genome-wide data from a three-generation pedigree of this species to uncover genetic signatures of domestication selection for growth. Genotyping-By-Sequencing (GBS) was used to generate genome-wide SNP data from a three-generation pedigree to calculate generation-wide averages of FST between every generation pair. The level of differentiation between generations was further investigated using ADMIXTURE analysis and Principal Component Analysis (PCA). After that, genome scans using Bayescan, LFMM and XP-EHH were applied to identify SNP variants under putative selection following selection for growth. Finally, genes near candidate SNP variants were annotated to gain functional insights. Analysis showed that between generations FST values slightly increased as generational time increased. The extent of these changes was small, and both ADMIXTURE analysis and PCA were unable to form clear clusters. Genome scans revealed a number of SNP outliers, indicative of selection, of which a small number overlapped across analyses methods and populations. Genes of interest within proximity of putative selective SNPs were related to biological functions, and revealed an association with growth, immunity, neural development and behaviour, and tumour repression. Even though few genes overlapped between outlier SNP methods, gene functionalities showed greater overlap between methods. While the genetic changes observed were small in most cases, a number of outlier SNPs could be identified, of which some were found by more than one method. Multiple outlier SNPs appeared to be predominately linked to gene functionalities that modulate growth and survival. Ultimately, the results help to shed light on the genomic changes occurring during the early stages of domestication selection in teleost fish species such as snapper, and will provide useful candidates for the ongoing selective breeding in the future of this and related species.
An Introductory Overview of Open-Source and Commercial Software Options for the Analysis of Forensic Sequencing Data
Authors: Huszar Tunde I. , Gettings Katherine B. , Vallone Peter M.
Published: November 2021

The top challenges of adopting new methods to forensic DNA analysis in routine laboratories are often the capital investment and the expertise required to implement and validate such methods locally. In the case of next-generation sequencing, in the last decade, several specifically forensic commercial options became available, offering reliable and validated solutions. Despite this, the readily available expertise to analyze, interpret and understand such data is still perceived to be lagging behind. This review gives an introductory overview for the forensic scientists who are at the beginning of their journey with implementing next-generation sequencing locally and because most in the field do not have a bioinformatics background may find it difficult to navigate the new terms and analysis options available. The currently available open-source and commercial software for forensic sequencing data analysis are summarized here to provide an accessible starting point for those fairly new to the forensic application of massively parallel sequencing.
Translating the Role of mTOR- and RAS-Associated Signalopathies in Autism Spectrum Disorder: Models, Mechanisms and Treatment
Authors: Vasic Verica , Jones Mattson S. O. , Haslinger Denise , Knaus Lisa S. , Schmeisser Michael J. , Novarino Gaia , Chiocchetti Andreas G.
Published: November 2021

Mutations affecting mTOR or RAS signaling underlie defined syndromes (the so-called mTORopathies and RASopathies) with high risk for Autism Spectrum Disorder (ASD). These syndromes show a broad variety of somatic phenotypes including cancers, skin abnormalities, heart disease and facial dysmorphisms. Less well studied are the neuropsychiatric symptoms such as ASD. Here, we assess the relevance of these signalopathies in ASD reviewing genetic, human cell model, rodent studies and clinical trials. We conclude that signalopathies have an increased liability for ASD and that, in particular, ASD individuals with dysmorphic features and intellectual disability (ID) have a higher chance for disruptive mutations in RAS- and mTOR-related genes. Studies on rodent and human cell models confirm aberrant neuronal development as the underlying pathology. Human studies further suggest that multiple hits are necessary to induce the respective phenotypes. Recent clinical trials do only report improvements for comorbid conditions such as epilepsy or cancer but not for behavioral aspects. Animal models show that treatment during early development can rescue behavioral phenotypes. Taken together, we suggest investigating the differential roles of mTOR and RAS signaling in both human and rodent models, and to test drug treatment both during and after neuronal development in the available model systems.
m6A mRNA Methylation Regulates LKB1 to Promote Autophagy of Hepatoblastoma Cells through Upregulated Phosphorylation of AMPK
Authors: Li Guohui , Deng Liang , Huang Nan , Cui Zhongqi , Wu Qi , Ma Ji , Pan Qiuhui , Sun Fenyong
Published: November 2021

The N6-methyladenosine (m6A) RNA modification can regulate autophagy to modulate the growth and development of tumors, but the mechanism of m6A modification for the regulation of autophagy in hepatocellular carcinoma cells (HCC) remains unclear. In the study, the knockdown of the Wilms’ tumor 1-associating protein (WTAP) was made in HCC to study the correlation between m6A modification and autophagy. A fluorescent confocal microscopy analysis showed that the knockdown of WTAP could facilitate the autophagy of HCC. A Western blot analysis showed that the level of p-AMPK was decreased in WTAP-knockdown HCC cells. Additionally, LKB1, the upstream kinase of AMPK, was regulated by WTAP and it could mediate the phosphorylation of AMPK in an m6A-dependent manner. Further studies revealed that the knockdown of WTAP could reduce the level of LKB1 mRNA with m6A. This could result in the increased stability of LKB1 mRNA to promote its expression. The knockdown of WTAP could upregulate the level of autophagy and inhibit HCC proliferation. However, the overexpression of WTAP could resist autophagic cell death.
CD34 and CD105 Microvessels in Resected Bone Specimen May Implicate Wound Healing in MRONJ
Authors: Marcianò Antonia , Ieni Antonio , Mauceri Rodolfo , Oteri Giacomo
Published: November 2021

Clinical treatment outcome of MRONJ (medication-related osteonecrosis of the jaw) surgery despite radical osseous removal and primary closure healing still shows differences in terms of outcome and disease recurrence. The study aims to assess the rate of angiogenesis of MRONJ lesions in order to understand the impact of angiogenesis and neoangiogenesis status on MRONJ surgical treatment outcome. This is the first study correlating microvessel density with prognosis in MRONJ surgically-treated patients. The immunohistochemical expression of CD34 and CD105 in MRONJ specimens obtained from surgically-treated patients was evaluated. The most vascularized areas detected by CD34 and CD105 were selected and the microvessel density value of the samples was registered. Samples were retrospectively divided according to the clinical outcome of MRONJ surgical treatment, dividing patients into two groups, “healed” and “not healed”. Statistical analysis was performed to assess if neovessels could influence treatment outcome in patients undergoing radical surgery. In the examined cohort, this value was highly predictive of better treatment outcome after radical surgery of MRONJ. Understanding of angiogenesis-dependent factors deserves further attention as a future target for MRONJ prevention and therapies.
Perceived Overqualification, Emotional Exhaustion, and Creativity: A Moderated-Mediation Model Based on Effort–Reward Imbalance Theory
Authors: Gong Zhanxue , Sun Fang , Li Xiyuan
Published: November 2021

Overqualification is prevalent in times of economic downturn, and research has increasingly focused on its outcomes. This study aimed to explore the psychological burden caused by perceived overqualification (POQ) and its impact on creativity among high-tech enterprise employees. Drawing from effort–reward imbalance theory, we examined the effect of POQ on emotional exhaustion, along with the mediating role of emotional exhaustion in the POQ–creativity relationship and the moderating role of pay for performance (PFP) in strengthening the link between POQ and emotional exhaustion. Using cross-sectional data from a sample of 359 employees in China, we found that (1) POQ was positively related to emotional exhaustion; (2) emotional exhaustion was negatively related to creativity; (3) PFP moderated the effect of POQ on emotional exhaustion as well as the indirect effect of POQ on creativity via emotional exhaustion. These findings have both theoretical and practical implications.
Origin of the Fastest 5 km, 10 km and 25 km Open-Water Swimmers—An Analysis from 20 Years and 9819 Swimmers
Authors: Seffrin Aldo , Knechtle Beat , Vancini Rodrigo Luiz , de Assis Teles Santos Douglas , de Lira Claudio Andre Barbosa , Hill Lee , Rosemann Thomas , Andrade Marilia Santos
Published: November 2021

In elite pool swimmers competing at world class level, mainly athletes from the United States of America and Australia are dominating. Little is known, however, for the nationality of dominating swimmers in elite open-water long-distance swimming races such as the official FINA races over 5 km, 10 km and 25 km—held since 2000. The aim of this study was to investigate the participation and performance trends by nationality of these elite open-water swimmers. Race results from all female and male swimmers competing in 5 km, 10 km and 25 km FINA races between 2000 and 2020 were analyzed. A total of 9819 swimmers competed between 2000 and 2020 in these races. The five countries that figure most times among the top ten in 5 km, 10 km and 25 km races over the years were Italy, Germany, Russia, Brazil and the Netherlands. In 10 km races, considering the all the athletes from each country, male athletes from Germany, Italy, and France presented faster race times than the other countries. In 10 km, female athletes presented no significant difference among the countries. In 5 and 25 km races, there were no differences between countries, for male and female athletes. Moreover, comparing only the 10 best results (top 10) from each country, there were no differences between countries in 5 km, 10 km and 25 km, for male and female athletes. Men were faster than women for all three distances. In summary, male swimmers from Europe (i.e., Germany, Italy, France) are dominating the 10 km FINA races. In the 5 km and 25 km FINA races, there is no dominating nationality, but among the top five countries in the top 10 over the years, three are European countries.
Association between Improvement of Oral Health, Swallowing Function, and Nutritional Intake Method in Acute Stroke Patients
Authors: Aoyagi Michiyo , Furuya Junichi , Matsubara Chiaki , Yoshimi Kanako , Nakane Ayako , Nakagawa Kazuharu , Inaji Motoki , Sato Yuji , Tohara Haruka , Minakuchi Shunsuke , Maehara Taketoshi
Published: November 2021

Stroke and poor oral health are common in older people, and the brain injuries associated with stroke are often accompanied by a decline in oral function. In this study, we investigated the characteristics of stroke patients who could not recover oral ingestion until discharge and the association between improved oral health, swallowing function, and nutritional intake methods in acute care. The subjects were 216 consecutive stroke patients who were admitted to Tokyo Medical and Dental University hospital and received oral health management. Nutritional intake, dysphagia, and oral health were evaluated using the Functional Oral Intake Scale (FOIS), Dysphagia Severity Scale (DSS), and Oral Health Assessment Tool (OHAT), respectively. Patients in the tube feeding group (FOIS level 1–2, N = 68) tended to have a worse general condition, fewer functional teeth, and a worse DSS level than those in the oral nutrition group (FOIS level 3–7, N = 148). Multiple analysis with improvement in FOIS score as the dependent variable showed that number of functional teeth (odds ratio [OR]: 1.08, p = 0.04) and improved DSS (OR: 7.44, p < 0.001) and OHAT values (OR: 1.23, p = 0.048) were associated with improvement in nutritional intake methods in acute care. Therefore, recovery of swallowing function and oral health might be important for stroke patients to recover oral ingestion in acute care.
A Machine Learning Approach for Spatial Mapping of the Health Risk Associated with Arsenic-Contaminated Groundwater in Taiwan’s Lanyang Plain
Authors: Liang Ching-Ping , Sun Chi-Chien , Suk Heejun , Wang Sheng-Wei , Chen Jui-Sheng
Published: November 2021

Groundwater resources are abundant and widely used in Taiwan’s Lanyang Plain. However, in some places the groundwater arsenic (As) concentrations far exceed the World Health Organization’s standards for drinking water quality. Measurements of the As concentrations in groundwater show considerable spatial variability, which means that the associated risk to human health would also vary from region to region. This study aims to adapt a back-propagation neural network (BPNN) method to carry out more reliable spatial mapping of the As concentrations in the groundwater for comparison with the geostatistical ordinary kriging (OK) method results. Cross validation is performed to evaluate the prediction performance by dividing the As monitoring data into three sets. The cross-validation results show that the average determination coefficients (R2) for the As concentrations obtained with BPNN and OK are 0.55 and 0.49, whereas the average root mean square errors (RMSE) are 0.49 and 0.54, respectively. Given the better prediction performance of the BPNN, it is recommended as a more reliable tool for the spatial mapping of the groundwater As concentration. Subsequently, the As concentrations estimated obtained using the BPNN are applied to develop a spatial map illustrating the risk to human health associated with the ingestion of As-containing groundwater based on the noncarcinogenic hazard quotient (HQ) and carcinogenic target risk (TR) standards established by the U.S. Environmental Protection Agency. Such maps can be used to demarcate the areas where residents are at higher risk due to the ingestion of As-containing groundwater, and prioritize the areas where more intensive monitoring of groundwater quality is required. The spatial mapping of As concentrations from the BPNN was also used to demarcate the regions where the groundwater is suitable for farmland and fishponds based on the water quality standards for As for irrigation and aquaculture.
Factors Associated with Reduction in Physical Activity during the COVID-19 Pandemic in São Paulo, Brazil: An Internet-Based Survey Conducted in June 2020
Authors: Togni Gabriela , Puccinelli Paulo José , Costa Taline , Seffrin Aldo , de Lira Claudio Andre Barbosa , Vancini Rodrigo Luiz , Santos Douglas De Assis Teles , Nikolaidis Pantelis Theodoros , Knechtle Beat , Andrade Marilia Santos
Published: November 2021

Background: The COVID-19 pandemic negatively affected physical activity levels. This study investigated the factors associated with the change in physical activity level in Brazilians residing in the city of São Paulo. Methods: A self-administered questionnaire, addressing personal data, restriction level, education level, family income, daily working hours, and physical activity level, was answered by 2140 volunteers, of which 1179 were excluded because the answers were either incomplete or the respondents were not from São Paulo. The total number of participants selected was 961 (581 female and 380 male). Results: The physical activity level adopted prior to the pandemic period (p < 0.001) and family income (p = 0.001) correlated significantly with physical activity level reduction during the pandemic. The proportion of people who reduced their physical activity was greater among those who were very active than those who were active (adjusted prevalence ratio [aPR]: 0.65 [confidence interval (CI): 0.52–0.80]) or insufficiently active [aPR: 0.39 (0.18–0.82)]. The proportion of people who reduced their physical activity was greater among those who received a salary less than minimum wage (MW) than those who received a salary between three to six times minimum wage [(aPR: 0.50 (CI 0.35–0.70)] or more than 6 MW [(aPR: 0.56 (CI 0.40–0.79)]. Conclusions: A higher prevalence of Brazilians residing in the city of São Paulo reduced their physical activity who had a vigorous level of physical activity prior to the pandemic and who received less than a MW.
The Effects of Wearing a Removable-Partial-Denture on the Bite Forces: A Cross-Sectional Study
Authors: Vozza Iole , Manzon Licia , Passarelli Pier Carmine , Pranno Nicola , Poli Ottavia , Grippaudo Cristina
Published: November 2021

Background: Removable partial dentures are a frequently used prosthetic treatment in the elderly population, but different types or RPDs might guarantee different chewing capabilities. In many studies, the relationship between chewing and aging has been reported and it has been shown that efficient chewing can improve the overall quality of life. Objectives: In the present study, the relationship between maximum bite force (MBF) and RPDs was studied. A relationship between the body mass index (BMI) and the type of prosthesis was also analyzed. Methods: 240 elderly patients, 120 males and 120 females, with bilateral posterior edentulism (class 1 of Kennedy classification) who had been wearing an RPD for at least a year, were recruited. Patients were divided into two groups: Group 1: male (n = 60) and female (n = 60) patients with bilateral edentulous areas located posterior to the remaining natural teeth and natural teeth in the opposite dental arch. Group 2: male (n = 60) and female (n = 60) patients with maxillary and mandibular bilateral edentulous areas located posterior to the remaining natural teeth. Their Body Mass Index (BMI) and Maximum bite force (MBF) were measured and compared according to the material and design of their RPD. Results: In both Groups, patients wearing cobalt-chrome alloy RPDs (Co-Cr-RPD) (Group 1: 20.25 ± 6.7 MBF, p < 0.001; Group 2: 16.0 ± 5.7 MBF, p < 0.001) had an increased MBF when compared to polymethylmethacrylate RPD (PMMA-RPD) (Group 1: 12.9 ± 3.36 MBF; Group 2: 10.4 + 2.8 MBF), and Valplast RPD (V-RPD) (Group 1: 14.3 ± 4.7 MBF; Group 2: 11.3 ± 3.4 MBF) users. There were no significant differences in bite force between patients wearing PMMA-RPD and V- RPD in both Groups. Patients in Group 2 showed a lower MBF than those in Group 1 (Group 1: 16.05 ± 6.13 MBF; Group 2: 12.6 ± 4.84 MBF; p < 0.001). Conclusions: A reduction in chewing force can lead to choosing softer foods for nutrition, which can lead to an increase in BMI. Our results show that only CoCr-RPD wearers were able to chew consistent food, whereas PMMA- RPD and V-RPD, due to the properties of the materials, their instability, and the possibility of causing pain during mastication, determined a limitation in the choice of food for many of the participants.
The Association of Recurrent and Multiple Types of Abuse with Adverse Mental Health, Substance Use, and Sexual Health Outcomes among Out-of-School Adolescent Girls and Young Women in Cape Town, South Africa
Authors: Myers Bronwyn , Browne Felicia A. , Carney Tara , Kline Tracy , Bonner Courtney Peasant , Wechsberg Wendee M.
Published: November 2021

Although physical and sexual abuse exposure is a well-established risk for poor health, the dimensions of abuse associated with health among socially vulnerable adolescent girls and young women (AGYW) remain underexamined. This article describes associations between combinations of abuse type and timing with mental health, substance use, and sexual risk outcomes among a sample of 499 AGYW (aged 16 to 19) who had left school early and were recruited for a cluster randomized trial in Cape Town, South Africa. Approximately one-third (33.5%; 95% CI: 28.7, 38.6) of participants reported lifetime abuse. Exposure to more than one type of abuse was associated with increased risk of depression (β = 3.92; 95% CI: 2.25, 5.59) and anxiety (β = 3.70; 95% CI: 2.11, 5.28), and greater odds of polydrug use (OR = 2.10; 95% CI: 1.02, 4.34) and substance-impaired sex (OR = 2.17; 95% CI: 1.31, 3.86). Exposure to multiple types of abuse during childhood/early adolescence and again in late adolescence was associated with increased risk of depression (β = 4.65; 95% CI: 3.15, 6.14), anxiety (β = 4.35; 95% CI: 2.70, 6.02), and polydrug use (OR = 2.37; 95% CI: 1.03, 5.73). Findings underscore the need for trauma-informed interventions that reduce mental health, substance use, and sexual risks among AGYW who have experienced multiple forms of abuse and recurrent abuse.