bluuebunny/crossref_metadata_2025 huggingface dataset:
Duration of sweat cyclophosphamide excretion in patients undergoing a conditioning regimen of high-dose cyclophosphamide for hematopoietic stem-cell transplantation
Authors: Tanigawa Hiromu , Hirohara Masayoshi , Marutani Yoshinori , Suzuki Yuji , Onizuka Makoto , Oda Shiori , Orita Mutsuko , Sato Masayo , Kushida Kazuki
Published: January 2022

Purpose

To investigate the duration of cyclophosphamide (CPA) excretion in the sweat after administration when receiving high-dose CPA therapy as a conditioning regimen for hematopoietic stem-cell transplantation (HSCT).

Methods

Shirts and pillowcases samples (changed once a day) from 12 patients, categorized as groups 1 (n  =  6), 2 (n = 4), and 3 (n  =  2), receiving high-dose CPA therapy were collected, sealed, stored at 4°C, and mailed to an analytical facility for CPA estimation using LC-MS/MS. CPA was administered intravenously at a dose of 60 mg/kg on days 1, 2 (closed-system delivery for group 3), and samples were collected during days 1–4 (groups 1,3) or days 1–9 (group 2).

Results

CPA was detected in all 126 shirts and pillowcases. In 9 patients, excluding 1 patient who had fever during the study period and group 3 patients, the mean (range) rate of CPA excretion in sweat was 0.03% (0.01–0.12%). The mean CPA excretion in 9 patients adjusted for body weight was 19.9 μg/kg on day 1 and 0.3 μg/kg on day 4.

Conclusions

This study showed that CPA was excreted for an extended duration in the patient's sweat, receiving a high-dose CPA therapy as a conditioning regimen against HSCT.
The effect of atropine used in dobutamine stress echocardiography on pupil diameter
Authors: Soulis Dimitrios , Papaioannou Theodore G , Zozolou Maria , Daskalopoulou Stella , Vlachopoulos Charalampos , Bethanis Dimitrios , Triantafyllou Dimitrios
Published: January 2022

Background

The use of atropine during dobutamine stress echocardiography (DSE) is contraindicated in persons with narrow angle glaucoma though there is limited evidence that low doses of intravenous atropine do not cause pupillary dilation.

Objective

The aim of this study is to investigate whether atropine when administered in persons without glaucoma during dobutamine stress echocardiography causes pupillary dilation.

Methods and Results

Out of 144 patients without a history of glaucoma referred for DSE for clinical indications, 105 patients received intravenous atropine doses ranging from 0.1 mg to 1.25 mg (most patients received 0.25–0.75 mg). Pupil diameter of both eyes was measured under the same light conditions before and after the DSE using a CP-30 Optical Digital PD Ruler. For the total of 210 examined eyes pupil diameter remained unaltered after each DSE test (3.65 ± 0.799 mm before vs 3.63 ± 0.766 mm after, p = .737). Similarly, pupil diameter remained unchanged when left and right eyes were assessed separately (right eye: 3.770 ± 0.812 before vs 3.752 ± 0.745 mm after, p = .821 and left eye: 3.521 ± 0.770 before vs 3.499 ± 0.770 mm after, p = .806). Diameter of right and left pupil were also unaltered after grouping patients by sex and iris pigmentation. Age, weight, atropine dose and propranolol dose were not correlated with changes in pupil diameter.

Conclusion

Intravenous atropine in usual doses administered in DSE does not cause mydriasis in adults without glaucoma. Future studies need to confirm our findings and expand the investigation regarding safety of atropine use during DSE in patients with narrow angle glaucoma.
Village health worker motivation for better performance in a maternal and child health programme in Nigeria: A realist evaluation
Authors: Mbachu Chinyere , Etiaba Enyi , Ebenso Bassey , Ogu Udochukwu , Onwujekwe Obinna , Uzochukwu Benjamin , Manzano Ana , Mirzoev Tolib
Published: January 2022

Background

Community health workers play an important role in linking communities with formal health service providers, thereby improving access to and utilization of health care. A novel cadre of community health workers known as village health workers (VHWs) were recruited to create demand for maternal health services in the Nigerian Subsidy Reinvestment Programme (SURE-P/MCH). In this study, we investigated the role of contextual factors and underlying mechanisms motivating VHWs.

Methods

We used realist evaluation to understand the impact of a multi-intervention maternal and child health programme on VHW motivation using Anambra State as a case study. Initial working theories and logic maps were developed through literature review and stakeholder engagement; programme theories were developed and tested using focus group discussions and in-depth interviews with various stakeholder groups. Interview transcripts were analysed through an integrated approach of Context, Mechanism and Outcomes (CMO) categorisation and connecting, and matching of patterns of CMO configurations. Motivation theories were used to explain factors that influence VHW motivation. Explanatory configurations are reported in line with RAMESES reporting standards.

Results

The performance of VHWs in the SURE-P maternal and child health programme was linked to four main mechanisms of motivation: feelings of confidence, sense of identity or feeling of acceptance, feeling of happiness and hopefulness/expectation of valued outcome. These mechanisms were triggered by interactions of programme-specific contexts and resources such as training and supervision of VHWs by skilled health workers, provision of first aid kits and uniforms, and payments of a monthly stipend. The monthly payment was considered to be the most important motivational factor by VHWs. VHWs used a combination of innovative approaches to create demand for maternity services among pregnant women, and their performance was influenced by health system factors such as organisational capacity and culture, and societal factors such as relationship with the community and community support.

Conclusion

This paper highlights important contextual factors and mechanisms for VHW motivation that can be applied to other interventions that seek to strengthen community engagement and demand creation in primary health care. Future research on how to sustain VHW motivation is also required.
Quality-of-life measurement in depression trials: A consumerist relic
Authors: McPherson Susan , Oute Jeppe , Speed Ewen
Published: January 2022

Quality-of-life measurement in depression is advocated as a patient-centred indicator of recovery, but may instead enhance the mimetic authority of randomised controlled trials (RCTs) which have been roundly critiqued in mental health. In this paper we draw on the social life of methods approach to extend the well-developed critique of RCTs into the field of quality-of-life measurement. We accomplish this through consideration and critique of the conceptual and epistemological development of quality-of-life measurement in depression, including the role of psychometrics in its development. Examining conceptual developments from the 1970s onwards, we consider how the scientific literature on quality-of-life in depression aligns with behavioural economics and consumerism but falls short of engaging with genuinely patient-centred approaches to recovery. We argue that quality-of-life measures in depression were developed within a consumerist model of healthcare in which the medical model was a central pillar and ‘choice’ a rhetorical device only. While quality-of-life instrument development was largely funded by industry, psychometrics provided no coherent solution to the ‘affective fallacy’ (high correlations between quality-of-life and depressive symptoms). Industry has largely abandoned the measures, while psychotherapy research has increasingly endorsed them. We argue that in their design and implementation, quality-of-life measures for depression remain based on a commercial model of healthcare, are conceptually flawed and do not support concepts of patient-centred healthcare.
The role of bilingualism in executive functions in healthy older adults: A systematic review
Authors: Degirmenci Merve Gul , Grossmann Judith Alina , Meyer Patric , Teichmann Birgit
Published: January 2022

Aims and Objectives:

Bilinguals have been claimed to develop superior executive functioning compared to monolinguals due to their continuous experience of controlling two languages. Given the developmental trajectory of executive functions, a bilingual advantage could be more pronounced at an advanced age. To gain a clearer understanding, we reviewed the effect of bilingualism executive functions in healthy older adults.

Methodology:

The present paper systematically examines the methods and the results of 24 studies from 22 articles comparing healthy older monolinguals and bilinguals in at least one domain of executive functions.

Data and Analysis:

Data of each study were extracted for sample characteristics, country, language background and measures, controlled confounders and task paradigms. Study quality was also calculated for each study.

Findings and Conclusions:

In general, nine out of the 24 studies fully supported the notion of a bilingual advantage. Four studies showed a bilingual disadvantage. The rest of the studies challenged the existence of a bilingual advantage, as neither full support for bilingual advantages nor bilingual disadvantages were seen in various domains. The available data did not clearly support the widespread notion that bilingualism is related to a general advantage in executive control. However, when looking at the domains of executive functions separately, bilingualism was reliably associated with an advantage in inhibition, especially in two commonly applied tasks: the Stroop test and the Simon task.

Originality:

This is the first systematic review aimed at exploring the link between bilingualism and executive functions in healthy older adults.

Significance/Implications:

Heterogeneity in study characteristics and control of confounding variables may partially explain some of the inconsistencies found between studies. Therefore, well-designed studies that measure all core domains of executive functions and consider confounding variables are urgently needed.
Uighur college students’ irony comprehension in Chinese
Authors: Chen Xiaoli , Li Degao , Wang Xiaolu
Published: January 2022

Aims and objectives/purpose/research questions:

Irony comprehension can be more demanding than literal comprehension in L1. This study aimed to seek an answer to how bilinguals perform in L2 in irony comprehension.

Design/methodology/approach:

Totally, 85 Uighur College students participated in a self-paced reading task in Chinese, with 81 Chinese native speakers as the controls. In Experiment 1, a scenario was followed by a commentary statement in which the critical word either was literally congruent with the context in meaning or could only be ironically understood. In Experiment 2, the same statement was preceded by three sentences which were either literally consistent with the critical word or created a context for the critical word to be understood ironically.

Data and analysis:

ANOVAs were conducted on participants reading times (RTs) to the critical words and commentary statement endings in the 14 pairs of discourses. They did not have different RTs for the critical words across the ironic and non-ironic conditions in L1, but had significantly longer RTs in the ironic condition than in the non-ironic condition in L2. Their RTs for the commentary statement endings were significantly longer in the ironic condition than in the non-ironic condition in both experiments, regardless of whether the materials were presented in L1 or L2.

Findings/conclusions:

Irony comprehension is similar in L2 to how it is in L1. However, salient meaning retrieval (in Experiment 1) and inference-making (in Experiment 2) in irony comprehension, as assumed by the Graded Salience Hypothesis, were more likely to be revealed in L2 than in L1.

Originality:

This seems to be the first study in the native and non-native domain of irony processing in the procedure of discourse reading.

Significance/implications:

L2 learners should do as many practices as possible to improve their reading proficiency in the target language.
Exploring the association between use of conversational artificial intelligence and social capital: Survey evidence from Hong Kong
Authors: Ng Yu-Leung
Published: January 2022

Media use–social capital research has studied traditional and social media use and associated social capital. Still, little is known about whether social capital would be cultivated or damaged by the use of conversational artificial intelligence (AI). This study explores the associations between conversational AI use and various measures of social capital using a territory-wide survey of an online representative sample in Hong Kong ( n = 1022). The results showed that conversational AI users ( n = 398) were more likely to have more offline and online bonding and bridging social capital, social trust, and civic participation than non-users ( n = 624). For the conversational AI users, intensity and frequency of conversational AI use were the positive predictors of the social capital measures. The findings demonstrated larger effect sizes for online bonding and bridging social capital than offline bonding and bridging social capital.
Dementia-friendly communities: The involvement of people living with dementia
Authors: Mathie Elspeth , Antony Arthur , Killett Anne , Darlington Nicole , Buckner Stefanie , Lafortune Louise , Mayrhofer Andrea , Dickinson Angela , Woodward Michael , Goodman Claire
Published: January 2022

Background

Dementia Friendly Communities (DFCs) offer an approach to community engagement to improve the lives of people living with dementia and their family supporters. The involvement of those living with dementia is key to creating successful DFCs. This paper examines how people affected by dementia were involved in developing and designing DFCs in England, and the impact of their involvement.

Methods

This study used a mixed method case study design in six DFCs in England. Data collection involved documentary analysis, a survey, and interviews and focus groups with service providers and people living with dementia and their supporters.

Findings

All six DFCs aspired to involve people living with dementia and their family supporters, but often relied on a small number of people living with dementia. The range of involvement activities in DFCs included Steering Group meetings, wider public consultations, and enabling feedback through data collection methods such as surveys and ‘ad hoc’ conversations. Organisations within the DFCs with experience of public consultation offered structured opportunities for involvement. There was no evidence of people living with dementia initiating or co-leading the organisation, its direction and/or the activities of the DFCs.

Conclusion

The involvement of people living with dementia in DFCs went beyond rhetoric, with some evidence of context sensitive and meaningful participation. Approaches towards involvement should focus on involvement in strategic planning, and on harnessing expertise in delivering different involvement activities to optimise participation of a greater breadth of people living with dementia. Engagement with local organisations who work with, and for, people living with dementia, and dedicating the resources needed for involvement work, are crucial for creating DFCs. The success of DFCs are determined by how the needs of people living with dementia are identified, discussed and reviewed by those within the community who are most affected.
Model-based damage identification with simulated transmittance deviations and deep learning classification
Authors: Seventekidis Panagiotis , Giagopoulos Dimitrios
Published: January 2022

Damage detection and identification is one of the main tasks in vibration based Structural Health Monitoring (SHM). The robustness of such SHM applications depends among others on the amount and quality of data that can be acquired. Model-based SHM methods may offer such data in unlimited numbers by simulating different structural states; however the main drawback remains the accuracy of models especially for small damages and early detection scenarios. In the present work, a method is presented where SHM data is generated though Finite Element (FE) models, simulating transmittance deviations from reference healthy states. The method is tested on a Carbon Fiber Reinforced Polymer truss for multiple damage scenarios of relatively realistic and small magnitude, affecting different truss members. The transmittance deviations for each scenario are approximated in the FE model by reducing the stiffness of the corresponding components simulating in parallel different uncertainties, resulting in a rich training dataset. The simulated data is finally passed to a Deep Learning (DL) classifier which is later validated on the experimental damages. The dataset is proven to provide to the DL classifier the appropriate information to generalize on the experimental states and the method has potential to contribute to model-based SHM applications. The numerical to experimental generalization is proven to depend on the uncertainty simulation of various model parameters.
Sport management education in an era of global neoliberalism and corporate influence on higher education
Authors: Barnes John C , Gannon William L
Published: January 2022

Decreasing government funding and increased corporate influence have combined to create transformation in higher education. Considering the shifting nature of higher education funding and the pressures that have come with this change, the purpose of this paper is threefold: First, an overview of the paradigm of higher education is provided, including a brief examination of how higher education in the US has evolved from the mid-20th Century to its current form. The point of this is to provide an explanation of how the corporate/entrepreneurial university has emerged. Within this discussion, ethical consequences of corporate funding are presented. Second, some approaches for exploiting external partnerships are discussed. Finally, innovative strategies for maintaining academic and professional ethics are proposed.
Risk factors associated with mortality in individuals with type 2 diabetes following an episode of severe hypoglycaemia. Results from a randomised controlled trial
Authors: Pearson Sam M , Kietsiriroje Noppadol , Whittam Beverley , Birch Rebecca J , Campbell Matthew D , Ajjan Ramzi A
Published: January 2022

Background

Severe hypoglycaemia may pose significant risk to individuals with type 2 diabetes (T2D), and evidence surrounding strategies to mitigate this risk is lacking.

Methods

Data was re-analysed from a previous randomised controlled trial studying the impact of nurse-led intervention on mortality following severe hypoglycaemia in the community. A Cox-regression model was used to identify baseline characteristics associated with mortality and to adjust for differences between groups. Kaplan-Meier curves were created to demonstrate differences in outcome between groups across different variables.

Results

A total of 124 participants (mean age = 75, 56.5% male) were analysed. In univariate analysis, Diabetes Severity Score (DSS), age and insulin use were baseline factors found to correlate to mortality, while HbA1C and established cardiovascular disease showed no significant correlations. Hazard ratio favoured the intervention (0.68, 95% CI: 0.38–1.19) and in multivariate analysis, only DSS demonstrated a relationship with mortality. Comparison of Kaplan-Meier curves across study groups suggested the intervention is beneficial irrespective of HbA1c, diabetes severity score or age.

Conclusion

While DSS predicts mortality following severe community hypoglycaemia in individuals with T2D, a structured nurse-led intervention appears to reduce the risk of death across a range of baseline parameters.
Families, Mental Health, and Delinquency: Testing Sexual Crime Typologies of Youth Who Sexually Harm
Authors: Brown Adam , Gardner Erin
Published: January 2022

Researchers have made great strides in identifying risk factors associated with the commission of sexual harm by youth. However, many of the risk factors associated with youth who sexually harm (YSH) are also associated with nonsexual delinquency, making it hard to create typologies of YSH to target prevention and treatment. To eliminate an overlap with nonsexually offending general delinquents, Brown (2019) used latent class analysis to identify four unique classes of youth based only on their sexual crime characteristics. A research implication of Brown's findings was to explore the relationship of the classes to characteristics associated with sexual crime by youth to identify targeted treatment implications and opportunities to prevent sexual crime. In this study, the authors used chi-square analyses and logistic regression to test the relationships of mental health, family factors, concurrent delinquency with the classes identified in Brown's (2019) study using the same sample ( N = 573) used by Brown. Findings highlight the potential differing etiology and treatment needs of YSH according to their offense characteristics. Treatment implications and directions for future research are offered.
Evaluation of the SafeHeal Colovac+ Anastomosis Protection Device: A Preclinical Study
Authors: De Hous Nicolas , Khosrovani Charam , Lefevre Jérémie H. , D’Urso Antonio , Komen Niels
Published: January 2022

Background

The protective ostomy is the current standard of care to protect a low colorectal anastomosis from leakage, but exposes patients to complications requiring an alternative strategy. The Colovac+ is a vacuum-based intraluminal bypass device designed to shield the anastomosis from fecal content, preventing the clinical outcomes of anastomotic leakage. The objective of this study was to evaluate the preliminary efficacy, safety, and technical feasibility of the Colovac+ in a porcine model. Methods: Twelve pigs received a colorectal anastomosis with Colovac+ implantation. The device was left in situ for 10 days and then retrieved endoscopically. Six pigs were to be sacrificed immediately after device retrieval and the other 6 were to be sacrificed on day 38. Clinical, endoscopic, and histopathological examinations were performed to evaluate the following endpoints: prevention of contact between the anastomosis and fecal content, device migration, feasibility of the implantation and retrieval procedure, collateral damage to the colonic wall, colon healing after device retrieval, and systemic toxicity related to the device. Results: Eleven pigs completed the study. One pig died prematurely due to a surgical complication unrelated to the device (bladder damage with uroperitoneum). There was no evidence of contact between the anastomosis and fecal content, none of the pigs developed symptomatic anastomotic leakage, there were no significant device migrations, and there was no evidence of systemic toxicity. Colovac+ implantation was easily performed in all cases except 1 (due to an inappropriate lubricant). Colovac+ retrieval was achieved successfully in all cases. Postretrieval examinations on day 10 revealed ulcerations at the anchoring site in 4 cases indicating mechanical damage caused by the stent. However, in the recovery group, no ulcerations were observed on day 38, and the colonic wall had properly healed in all animals. Conclusions: The Colovac+ is a technically feasible, safe, and efficient device for the protection of a colorectal anastomosis in a porcine model. The device holds promise for clinical use and warrants further research.
A new model based on belief rule base and membership function (BRB-MF) for health state prediction in sensor
Authors: Yin Xiaojing , Shi Guangxu , Peng Shouxin , Zhang Bangcheng , Guo Huachao
Published: January 2022

Health state prediction is an effective way to improve the reliability for sensors. In the process of sensor degradation, it is difficult to obtain more effective monitoring data. And in the classification of health states, how to identify the adjacent state is also a problem. This paper proposed a health state prediction model based on belief rule base (BRB) and membership function (MF), which is called BRB-MF. In the model, BRB can make full use of expert knowledge and poor effective data. In the prediction results of BRB, it may be not completely logical or not entirely appropriate facing adjacent states of sensor. In order to solve the problem, MF is used to continue the analysis of the predicted results of BRB. In the BRB-MF model, the covariance matrix adaptation evolutionary strategies (CMA-ES) optimization algorithm is used to update the model parameters to make up for the uncertainty of expert knowledge. In the end, the brightness sensor of the rail vehicle LED lighting system is taken as a case study. The results show that the BRB-MF model can predict the health state of sensor with a high accuracy and a reasonable state.
Compensated and non-compensated patient injury claims in internal carotid artery interventions in Finland, 2004–2017
Authors: Laukkavirta Minna , Blomgren Karin , Rautio Riitta , Nikulainen Veikko , Helmiö Päivi
Published: January 2022

Objectives

Analysis of patient injuries offers possibilities for improving quality in patient care. The aim of this study was to identify errors and adverse events leading to patient injuries in the treatment of internal carotid artery stenosis (ICAS).

Methods

A retrospective analysis was performed on data from Finnish patient injury claims and patient insurance center decisions in the treatment of ICAS, 2004–2017. Contributing factors to injury were identified and evaluated.

Results

During the 14-year study period, 42 patient injury claims involving ICAS treatment were closed in Finland. One claim involved carotid artery stenting, and the other operations were carotid artery endarterectomies. Nine of the claims were compensated (seven for operations and two for evaluations). Fully trained vascular surgeons had carried out all the operations and evaluations. Stroke was the most common complaint in the claims ( n = 12). Six of the compensated patients were symptomatic prior to the interventions. Injuries were related to errors in decision-making and patient selection in two cases. Four patients received compensation for nerve injury and three for stroke. No deaths were compensated as patient injuries. Most negative claim decisions were related to the injury having been unavoidable.

Conclusion

Compensated patient injuries involving the treatment of ICAS are rare but often serious and mostly involve open surgery. Patient injury claims provide a valuable source of information for recognizing errors in care and offer possibilities to improve patient safety.
The tyranny of student satisfaction: Cruel optimistic fantasies in education
Authors: Hansen Dion Rüsselbæk , Mellon Karsten
Published: January 2022

In this theoretical paper, we reflect on the optimistic neoliberal fantasies that are played out in today’s education, even though that they rarely live up to their promises. Inspired by Lauren Berlant’s concept of cruel optimism, and psychoanalytical thinkers as Slavoj Žižek and Ilan Kapoor, and their focus on concepts such as fantasy, desire, enjoyment, and the unconscious, we argue that there is a contemporary tendency for critical thinking and complicated conversations to be neglected or avoided in education, especially these forms of thinking and conversations that can question the neoliberal fantasmatic order and the cruelnss as well as the enjoyment that come with it. Instead, educational institutions and educators must live up to the demands of the big (neoliberal market) Other and its desire for positive student evaluations that mirror satisfaction and quality regarding the educational “product” that students are promised. How it looks will be illustrated by means of examples that derive from a Danish educational context. On that basis, we claim that we are witnessing a form of satisfaction tyranny in education and discuss what it means if educational institutions and educators cannot release themselves from their neoliberal involvement.
The Six-Year-Old ‘Adult’
Authors: Donnell Christopher C. , Johnston Matthew J. , Foley Jennifer I.
Published: January 2022

Children are not miniature adults, yet when a child celebrates their sixth birthday, little do they know that, with the arrival of their first ‘adult’ tooth, they are about to gain their first real experience of being a ‘grown-up’. The age of six is a key milestone in the mental, physical and emotional wellbeing of children, with most children in the UK having commenced primary school education by their fifth birthday. Six-year-olds are about to enter the most critical period in their dental development, the mixed-dentition phase, where their mouths are in a near continuous state of flux. This pivotal age in their dental development should not be undervalued; the dental decisions we make at this age means childhood lasts a lifetime. Caries is the most prevalent, preventable global disease, and with one in four children suffering from dental caries in the primary dentition by the time they start school, the foundations we lay down at the age of six translate into lifelong benefits for the permanent dentition. In this paper, the aim is to demonstrate that at the age of six we get a second chance to get things right. From caries risk factors and tailoring the five pillars of prevention by educating parents on the developing dentition, to reinforcing the importance of habit-breaking, developmental anomalies of enamel and early orthodontic intervention, this paper describes the importance of the age of six, never before so exclusively expressed in a dental sense.
Parental Views on Minimally Invasive Dentistry versus General Anaesthesia Extractions of Children’s Compromised First Permanent Molars: An Exploratory Qualitative Study
Authors: Agel Mona , Scambler Sasha , Hosey Marie Therese
Published: January 2022

Introduction:

The current standard of care for first permanent molars (FPMs) requiring extraction is removal of these teeth between the chronological ages of eight to ten years, as per UK guidelines.1 This often involves a general anaesthetic (GA) with surgical admission to hospital. This study explores parental views on minimally invasive (MI) techniques as an alternative to the UK current standard of care for extractions of FPMs deemed to require removal between the chronological ages of eight to ten years.

Methods:

A qualitative investigation, using semi-structured interviews was conducted with parents/carers of children attending a teaching hospital for extraction of compromised FPMs under GA. Thematic framework analysis was used to present the findings. The consolidated criteria for reporting qualitative research (COREQ) were used as a guide to ensure quality.

Results:

The main themes emerging were: participants’ surprise at how poor the prognosis was for their child’s FPMs; acceptance that care was beyond the scope of primary care; willingness by some to undergo GA again; requests for information about the guarantee of success of MI treatment; concerns about the residual black staining from silver diamine fluoride (SDF); and acceptance of extraction spaces because of potential future failure of MI.

Conclusion:

This exploratory qualitative study has shown that, while extraction of compromised FPMs under GA is accepted by most parents/carers, there appears to be a growing acceptance of MI approaches to restore FPMs instead of extraction of these teeth.
Factors affecting subjective health of child-rearing-aged Japanese adults, considering the effect of healthy life expectancy: A cross-sectional study
Authors: Taira Kazuya
Published: January 2022

Objectives:

The extension of healthy life expectancy is an important policy issue in Japan. This study aimed to clarify the association between subjective health and healthy life expectancy and identify the factors that improve subjective health of child-rearing-aged adults in Japan.

Methods:

A cross-sectional study was conducted. We used data from 2718 participants of the Japanese General Social Survey 2009 Life Course Study. The mean age was 35.5 ± 4.10 years, and 56% were female. Multivariate logistic regression analysis was performed on subjective health, which was treated as a binary variable when calculating healthy life expectancy as an objective variable. The predictors were gender, age, marital status, number of family members living in the home, household income, mental health score, age of youngest child, and the person from whom one seeks help. The prefecture where the participants resided was treated as a control variable.

Results:

There was no association between individual subjective health and healthy life expectancy. Mental health score (measured by the Mental Health Inventory-5, MHI-5) was significantly associated with subjective health. With a MHI-5 score of ⩽ 10 points as the reference criterion, as the score increased, the odds ratio of subjective health increased, and for MHI-5 scores ⩾ 16 points, odds ratio was 14.14 (confidence interval: 7.57–26.38).

Conclusion:

Among the child-rearing-aged adults, prefectural healthy life expectancy was not associated with individual subjective health. Mental health was significantly associated with subjective health and may be underestimated in calculating healthy life expectancy.
The effect of watching shoulder ROM changes on functional outcome and quality of life following arthroscopic rotator cuff repair
Authors: Ozcamdalli Mustafa , Eken Gokay , Misir Abdulhamit , Oguzkaya Sinan , Uzun Erdal
Published: January 2022

Purpose

This study aimed to evaluate the effectiveness of watching video records of their shoulder motion changes on functional outcomes and quality of life after arthroscopic rotator cuff repair (ARCR). Methods The patients were divided into two groups. In Group 1, video records of pre- and postoperative shoulder motions were recorded and showed. In Group 2, no video was showed to the patients. In Group 1, the first postoperative evaluation was done before video watching, and the second evaluation was done just after watching video records. In Group 2, the first and second postoperative measurements were performed with 10–20 days interval. The Constant Murley score (CS), the American Shoulder and Elbow Surgeons score (ASES), the Short-Form 36 (SF-36) score, and active shoulder range of motion (ROM) values were used as an outcome tool. Results A total of 196 patients (Group 1; 76 patients and Group 2; 120 patients) with a mean age of 62.06 ± 7.17 years were included. There was a significant improvement in postoperative scores of SF-36 subscales (except emotional well-being and energy/fatigue), ASES, CM scores, and joint ROM values when compared to preoperative values for both groups ( p < .001). The first postoperative outcomes were similar between groups ( p > .05). In the second postoperative evaluation, emotional role functioning, energy/fatigue, emotional well-being, health change subscales of SF-36, and ASES scores were significantly higher in Group 1 compared with Group 2 ( p < .05). Conclusion When patients watch the pre- and postoperative video records of their shoulder ROM after ARCR, patients’ satisfaction and well-being perception increase in the short-term despite unchanged shoulder ROM.
Administration of Tranexamic Acid to Reduce Intra-articular Hemarthrosis in ACL Reconstruction: A Systematic Review
Authors: Na Yuyan , Jia Yanbo , Shi Yuting , Liu Wanlin , Han Changxu , Hua Yinghui
Published: January 2022

Background:

Although tranexamic acid (TXA) has been shown to reduce bleeding in joint replacement procedures, its effectiveness for anterior cruciate ligament reconstruction (ACLR) has not been widely reported.

Purpose:

To evaluate the effectiveness of TXA to reduce postoperative hemarthrosis and improve clinical outcomes after ACLR.

Study Design:

Systematic review; Level of evidence, 2.

Methods:

A systematic review of the literature following the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) was performed; literature retrieval was carried out using the MEDLINE, Embase, and Cochrane Library electronic databases. The inclusion criteria were comparative studies in English that reported the administration of intravenous or intra-articular TXA versus other modalities or placebo in patients undergoing ACLR.

Results:

Six studies comprising 418 patients who were treated with TXA were included. Heterogeneity among studies did not allow for the pooling of data. Five studies showed decreased drainage volume in the first 24 or 48 hours postoperatively as compared with control (ACLR with no TXA). Four studies showed lower hemarthrosis grades and visual analog scale scores in TXA versus control in the early postoperative period, although this difference was not evident at 4 weeks postoperatively. No studies showed differences in infection, deep venous thrombosis, or adverse events between the TXA and control groups.

Conclusion:

The current best available evidence suggests that TXA administration at the time of ACLR results in decreased intra-articular bleeding (measured using a drainage system), hemarthrosis grade, and pain when compared with control.
The Disease Burden of Generalized Pustular Psoriasis: Real-World Evidence From CorEvitas’ Psoriasis Registry
Authors: Lebwohl M , Medeiros R A. , Mackey R H. , Harrold L R. , Valdecantos W C. , Flack M , Golembesky A K. , Kotowsky N , Strober B
Published: January 2022

Background: Generalized pustular psoriasis (GPP) is a rare, systemic disease characterized by persistent or recurrent flares of painful neutrophilic pustules. There is limited real-world evidence characterizing patients with GPP. Objectives: To establish the distinguishing characteristics of GPP relative to plaque psoriasis, and help inform future treatment decisions and improve patient outcomes. Methods: North American adults with GPP or plaque psoriasis (without pustules) identified from CorEvitas’ Psoriasis Registry were included in this dataset. Registry enrollment data, including patient sociodemographics, disease characteristics, medication use, and patient-reported outcome measures were compared for patients with GPP vs those with plaque psoriasis. This study was descriptive, and no hypothesis tests were performed. Results: In this sample, patients with GPP (N = 60) reported greater median (interquartile range) pain (20 [3-62] vs 5 [0-35]), fatigue (44 [15-73] vs 20 [4-50]), and itch (59 [10-85] vs 22 [5-70]) than those with plaque psoriasis (N = 4894). Descriptively, patients with GPP also reported more anxiety and depression (EQ-5D-3L: 38% vs 26%) and had more treatment experience (≥2 previous systemics: 15% vs 7%). Conclusions: A greater degree of symptom severity and impact on quality of life was reported by patients with GPP compared with plaque psoriasis in this sample. Importantly, patients with GPP had more treatment experience, suggesting that current treatment options do not adequately resolve the disease—highlighting the need to develop more effective GPP treatments.
The role of trust in the positioning of children with Migrant Backgrounds: Reflections on teachers’ narratives from London primary schools
Authors: Farini Federico , Scollan Angela
Published: January 2022

Based on qualitative interviews with primary school teachers in Greater London, this article explores teachers’ narratives to uncover how Children with Migrant Backgrounds (CMB) are positioned in the contexts of their learning experience. In particular, the article utilises the analytical category of trust to argue that the position of CMB in teachers’ narratives is related to the form of teachers’ trust. When trust is based on categorical inequalities, CMB are often considered untrustworthy partners in the construction of the learning and teaching experience. Trust based on categorical inequalities becomes a form of trust in distrust and CMB are positioned in the children’s needs paradigm where decision-making is reserved to teachers who act for them and on their behalf. When trust is based on personal relationships, CMB are positioned as agents who are capable to voice their interests, bringing about consequential changes in the contexts of their experiences. CMB are positioned in the children’s interests paradigm, where agency is expected and promoted as a right of children who are socially constructed as agents who can make a difference with their choices.
Stable isotope and geochemical evidence for genesis of secondary copper deposits at Girilambone, New South Wales, Australia
Authors: Melchiorre Erik B.
Published: January 2022

The Girilambone copper deposit of New South Wales, Australia, serves as an end-member model for development of a classic oxidation-zone profile in an environment virtually free of both the effects of active tectonics and significant fluctuation in the local water table. The oxidation zone of other copper deposits may be interpreted for history of recently active tectonics, palaeoclimate, and water-table stability by comparison to the Girilambone deposit. Unlike the oxidation profiles of porphyry copper deposits of western North America, which have been overprinted by many water-table fluctuations produced by active tectonics, the Girilambone deposit appears to have little modification to the original oxidation profile. Oxidation of primary sulfides at Girilambone was an exothermic process facilitated by chemolithotrophic bacteria, recorded by malachite oxygen isotope thermometry estimates of up to 52°C, and very light malachite carbon isotope values. The bacteria generated CO2 which migrated upwards to react with copper rich meteoric fluids of the vadose zone to precipitate malachite. Unlike porphyry copper deposits of western North America which experienced recent tectonic activity, the secondary minerals (clays, iron oxides and copper carbonates) at Girilambone were not repeatedly fractured and offset during oxidation to re-establish permeability. This reduced permeability of the oxidation zone and slowed the release of CO2 from the system, producing significantly elevated partial pressure of CO2, sufficient for azurite formation to dominate. Azurite oxygen and carbon isotope values indicate formation at lower temperatures up to 32°C, and with less bacterial activity than for malachite. The sulfide-digesting bacteria at Girilambone were relatively free of seasonal swings in population, as the deposit does not have the interbanded azurite and malachite typical of episodic bacterial populations triggered by seasonal precipitation. Thus the absence of significant Cu-carbonate banding at Girilambone serves as a palaeoclimate indicator. Deeper in the Girilambone oxidation zone, native copper and cuprite dominate, whereas chalcocite formed an enrichment blanket just above and at the modern water table. Oxygen and carbon isotope values for pseudomorphs of malachite after azurite indicate that these were generated as a retrograde reaction when CO2 production from bacterial digestion of sulfides waned and temperatures in the oxidation zone were near ambient. In the post mining environment, chloride-rich groundwater seeps actively precipitate atacamite, while exposed remnants of sulfide masses form an outer rind of porous malachite. Exceptions to this oxidation zone sequence occur due to localised fluid channelisation and perched water-table lenses that generated mineralogical overprints.
Omega-3 fatty acids impair miR-1-3p-dependent Notch3 down-regulation and alleviate sepsis-induced intestinal injury
Authors: Chen You-Lian , Xie Yin-Jing , Liu Zhen-Mi , Chen Wei-Bu , Zhang Ru , Ye Hong-Xing , Wang Wei , Liu Xue-Yan , Chen Huai-Sheng
Published: January 2022

Background

Sepsis is a troublesome syndrome that can cause intestinal injury and even high mortality rates. Omega-3 fatty acids (FAs) are known to protect against intestinal damage. Accordingly, the current study set out to explore if omega-3 FAs could affect sepsis-induced intestinal injury with the involvement of the microRNA (miR)-1-3p/Notch3-Smad axis.

Methods

First, cecal ligation and perforation (CLP) was performed to establish septic mouse models in C57BL/6J mice, and mouse intestinal epithelial MODE-K cells were induced by lipopolysaccharide (LPS) to establish sepsis cell models. The CLP-induced septic mice or LPS-exposed cells were subjected to treatment with Omega-3 FAs and activin (Smad signaling activator), miR-1-3p inhibitor and over-expressed/short hairpin RNA (oe-/sh)-Notch3 to explore their roles in inflammation, intestinal oxidative stress and cell apoptosis. A dual-luciferase reporter gene assay was further performed to verify the regulatory relationship between miR-1-3p and Notch3.

Results

Omega-3 FAs inhibited CLP-induced intestinal injury and ameliorated LPS-induced intestinal epithelial cell injury by down-regulating miR-1-3p, as evidenced by decreased levels of tumor necrosis factor-α, interleukin-1β (IL-1β) and IL-6, in addition to diminished levels of reactive oxygen species, malondialdehyde levels and superoxide dismutase activity. Furthermore, miR-1-3p could down-regulate Notch3, which inactivated the Smad pathway.

Conclusion

Collectively, our findings indicated that omega-3 FAs elevate the expression of Notch3 by down-regulating miR-1-3p, and then blocking the Smad pathway to alleviate intestinal epithelial inflammation and oxidative stress injury caused by sepsis.
Implementation of motivational interviewing in the general practice setting: a qualitative study
Authors: Boom Saskia M , Oberink Riëtta , Zonneveld Abigail J E , van Dijk Nynke , Visser Mechteld R M
Published: January 2022

Background

General Practitioners (GPs) and Practice Nurses (PNs) collaboratively play an important role in preventing and monitoring chronic diseases. They are trained in Motivational Interviewing (MI), which is a communication style to intrinsically motivate patients to a healthier lifestyle. However, being trained in MI skills does not necessarily mean that it is implemented in daily practice so patients actually benefit. The aim of this study is to identify factors that facilitate or impede the implementation of MI in General Practice.

Methods

A total of 152 participants (93 GP-trainees and 59 PN-trainees) who were trained in MI completed a questionnaire regarding the implementation of MI. Semi-structured interviews (N = 17) were conducted with GPs and PNs (ranging from almost graduated to highly experienced) who were selected through the process of maximum variation sampling. The interview guide was based on the five-stage implementation model of Grol and Wensing.

Results

Thirteen factors that influence the implementation of MI in General Practice were identified. They can be allocated to three categories: (1) setting factors such as time, (2) GP/PN factors such as self-efficacy, and (3) patient factors such as cultural background.

Conclusions

Overall, GPs and PNs considered MI to be useful and part of their professional responsibility. Most difficulties become apparent in stage 4 (change: applying MI skills in practice) and 5 (consolidation: integrating MI into daily routine and embedment in organisation) of Grol and Wensing’s model. Therefore, it is important that training does not only focus on MI skills. It is essential to pay explicit attention to the factors that impact implementation, as well as the appropriate tools to tackle the barriers. These insights can help trainers to effectively support GPs and PNs to apply and maintain their MI skills in daily practice.