bluuebunny/crossref_metadata_2025 huggingface dataset:
Co-incubation of Short Amphiphilic Peptides with Dicer Substrate RNAs Results in β-Sheet Fibrils for Enhanced Gene Silencing in Cancer Cells
Authors:   Present address: Genes N Life Healthcare Pvt. Ltd., Hyderabad, Telangana,500082, India, Gupta Kshitij , Parlea Lorena , Puri Anu , Bergman Joseph T. ,   RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA, Viard Mathias ,   Basic Science Program, Leidos Biomedical, Research Inc., Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA, Smith Katelyn ,   Pharmaceutical Sciences, Merck Research Laboratories, Merck & Co., Inc, Kenilworth New Jersey, USA, Kim Taejin ,   Department of Physical Sciences, West Virginia University Institute of Technology, Beckley 25801, West Virginia, USA, Shapiro Bruce A. ,   RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA
Published: January 2025

RNA can interact with positively charged, amphiphilic peptides to cooperatively assemble into fibrils that enable RNA transport across cancer cellular membranes. RNA decreases the folding energy barrier imposed by the electrostatic repulsion between these charged peptides, thus partaking in RNA-peptide self-assembly along particular pathways in the energy landscape. Specific amphiphilic peptides capable of protecting and transporting RNA across a membrane have Type II’ β-turn hairpin forming motifs in their structures, which aids self-assembly into β-sheet fibrils. We employed a set of such cationic, amphiphilic peptides that have random coiled structures in the absence of folding stimuli, to characterize the (peptides):(RNA) assembly. We subjected these complexes to extensive biophysical characterization in vitro and in cell culture. We show that short RNAs (such as Dicer substrate RNAs) can lead these peptides to self-assemble into β-sheet fibrils that have RNA transport capabilities and can act as non-viral delivery vectors for RNA. Modulation in the peptide sequence implicitly alters the way they bind RNA and influence the peptides’ ability to transport nucleic acids across membranes.
The Reduction of Traumatic Spinal Cord Secondary Injury by Anti-RhoA siRNA Functionalized Nucleic Acid Nanoparticles (NANPs)
Authors:   UNC Charlotte, NC, USA, Beasock Damian , Chandler Morgan , Radwan Yasmine , Panigaj Martin ,   UNC Charlotte, NC, USA, Liao Zhen , Ma Fuying ,   Drug Design Development and Delivery (4D) Laboratory, Department of Bioengineering, Clemson University, SC 29631, USA, Webb Ken ,   Microenvironmental Engineering Laboratory, Department of Bioengineering, Clemson University, SC 29631, USA, Lee Jeoung Soo ,   Drug Design Development and Delivery (4D) Laboratory, Department of Bioengineering, Clemson University, SC 29631, USA, Afonin Kirill A. ,   UNC Charlotte, NC, USA
Published: January 2025

Primary injury of the spinal cord is caused by a mechanical traumatic event which is rapidly followed by a secondary injury cascade that may evolve for several months leading to biological and functional changes. During the secondary injury, many pathophysiological pathways and process are activated including inflammation, oxidative stress, demyelination, excitotoxicity, axon degeneration, and cell death. The RhoA/Rho kinase pathway significantly contributes to spinal degeneration and regeneration and therefore represents a potential therapeutic target. Nucleic acid nanoparticles (NANPs) offer easy rational and programable design with the potential to carry on multiple synergistic therapeutic nucleic acid functional motifs. In this context we designed, synthesized, and assembled several representative NANPs decorated with multiple copies of siRNAs targeting RhoA. Subsequently we assessed NANPs' physicochemical properties, toxicity, and immunorecognition upon delivery with the nanocarrier PLGA-g-PEI (PgP), developed with the aim to select for the most immunoquiescent type of formulations. In addition, we observed that L1 neural cell adhesion molecule conjugated PgP (L1-PgP) efficiently delivered NANP-siRhoA in cultured neuroblastoma (B35) cells. RhoA mRNA expression was significantly reduced by all L1-PgP/ NANP-siRhoA relative to the untreated control, while no significant differences were observed between the different NANP-siRhoAs.
pH-responsive bond as a linker for the release of chemical drugs from RNA–drug complexes in endosome or lysosome
Authors:   Markey Cancer Center and Department of Surgery, University of Kentucky, Lexington, KY 40536, USA, Rychahou Piotr , Zaytseva Yekaterina Y. , Weiss Heidi L. , Evers B. Mark ,   Markey Cancer Center and Department of Surgery, University of Kentucky, Lexington, KY 40536, USA;, Guo Sijin ,   Center for RNA Nanobiotechnology and Nanomedicine, The Ohio State University, Columbus, OH, USA, Zhang Yinan ,   Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China, Rychagov Nicole ,   Department of Pharmaceutical Sciences; Center for Pharmaceutical Research and Innovation, University of Kentucky, Lexington, KY 40536, USA, Guo Peixuan ,   College of Pharmacy; Center for RNA Nanobiotechnology and Nanomedicine; Comprehensive Cancer Center; Dorothy M. Davis Heart and Lung Research, The Ohio State University, Columbus, OH, USA
Published: January 2025

Emerging phenomena have signaled that RNA therapeutics will be the third milestone in pharmaceutical drug development. RNA nanoparticles display motile and deformable properties that lead to (1) fast and efficient tumor accumulation via both spontaneous and active targeting, and (2) fast renal excretion of non-tumor-accumulated nanoparticles due to RNA’s negative charge and dynamic property; thus, undetectable toxicity. Here, we report the use of RNA nanoparticles to harbor the cancer-targeting ligand and chemical drugs and the design of the pH-responsive bond as a linker for the release of chemical drugs from RNA–drug complexes in endosomes or lysosomes. RNA nanoparticles constructed from a three-way junction (3WJ) core of bacteriophage phi29 packaging RNA (pRNA) offer an advanced strategy for receptor-selective drug delivery into cancer cells and has the potential to enhance the efficacy of anti-cancer therapies while mitigating dose-limiting toxicity in patients with colorectal cancer (CRC). We investigated conjugation of small-molecule drugs targeting the PI3K/mTOR pathway to 3WJ RNA nanoparticles and confirmed intracellular drug delivery by 3WJ RNA nanoparticles into CRC cells. 3WJ a, a single strand of 3WJ nanoparticle, was constructed with a pH-sensitive linkage conjugated to a dual PI3K/mTOR inhibitor, PI-103-azide. We demonstrated PI-103 conjugation to RNA under normal physiologic pH conditions and rapid pH-dependent drug release in an acidic environment. Next, we assembled FA-3WJ-PI103 nanoparticles from three single-stranded RNA, 3WJ a-PI-103, 3WJ b and 3WJ c-folate, to specifically target folate receptor alpha (FRα). Our tests demonstrated receptor-mediated uptake of FA-pRNA-PI-103 nanoparticles, pH-responsive PI-103 drug release from lysosomes and inhibition of the PI3K/mTOR pathway in CRC cells and tumor spheroids. These results confirm receptor-mediated cytosolic drug delivery by pH-responsive RNA nanoparticles and demonstrate potential of the 3WJ–drug complex as a novel strategy for receptor-selective drug delivery to cancer cells with high FRα expression.
ATHLETE, HYMEN OR MELEAGER? AN INTAGLIO FROM OLBIA
Authors:   Jagiellonian University, Institute of Archaeology, Gołyźniak Paweł , Twardecki Alfred ,   Polish Academy of Sciences, Institute of Archaeology and Ethnology
Published: January 2025

An intaglio found during National Museum in Warsaw excavations at the Olbia Pontica site in 2018 depicts a young male figure with a torch. This gem, made of carnelian, is dated to the end of the first century BC and the beginning of the first century AD. The identification of the figure engraved on stone considers three different possibilities: athlete, Hymen and Meleager, and discusses it in the context of an unknown possible sculptural model for the representations as well as remarks on personal choice of subjects to be engraved on gemstones. The find is contextualized from a historical and archaeological point of view within Roman-period Olbia Pontica. It is postulated that the gem may have belonged to a high-ranking Roman officer or a member of the local elite, and it is important testimony for the early presence of Romans in Olbia or at least their contacts with the indigenous population.
The Influence of Price, Product Completeness, and Ease of Use of the Bukalapak Application on Purchase Decisions on the Bukalapak Application in Mataram City
Authors: Hastati Ayu
Published: January 2025

This study aims to analyze the influence of price, product completeness, and ease of use of the Bukalapak application on purchasing decisions in Mataram City. With the rise of online shopping trends, it is important to understand the factors that influence consumers' decisions in choosing an e-commerce platform. This study uses a quantitative method with data collection through questionnaires distributed to Bukalapak users in Mataram. The results of the analysis show that price has a significant influence on purchasing decisions, where consumers tend to choose products at prices that match the quality offered. In addition, product completeness also plays an important role, because the variety of product choices provides flexibility for consumers to choose according to their needs. The ease of use of the app is another factor that is no less important; An easy-to-use app increases user convenience and encourages them to make purchases. Overall, this study provides valuable insights for business actors in Bukalapak to improve their marketing strategies by considering the factors that influence consumer purchasing decisions. These findings are expected to help increase customer satisfaction and loyalty.
Dr. Hugo Dibarboure Icasuriaga Aportes a la salud comunitaria
Authors: Martínez Dibarboure Fabrizio
Published: January 2025

A partir de la obra pictórica del pintor uruguayo José Cuneo Perinetti (1887-1977), nos iremos acercando a la vida y praxis del médico uruguayo Hugo Dibarboure Icasuriaga (1929-2015), quien empezó su caminar mientas el pintor hacía sus lunas sobre Florida. Desde un abordaje que tendrá en cuenta la perspectiva antroplógica, mezclada con aportes históricos, reflexiones filosóficas y experiencia práctica asistencial, analizaremos el aporte de Hugo a la medicina familiar y comunitaria, descubriendo en él a un médico-docente que, sigue dejando su huella por el transitar de la salud comunitaria nacional.
Superparasitism and Multiparasitism of the Mango Leafhoppers by Halictophagus fulmeki (Hofeneder)and Callipharixenos philippines Kathirithamby & McMahon (Strepsiptera)
Authors: Soe Myint Myint , Ocampo Virginia R. , Caoili Barbara L. , Javier Pio A. , Rebancos Carmencita M.
Published: January 2025

Halictophagus fulmeki (Hofeneder) (Strepsiptera: Halictophagidae) and Callipharixenos philippines Kathirithamby & McMahon (Strepsiptera: Callipharixenidae) were found to parasitize the three (3) species of mango leafhoppers in the UPLB campus. The parasitization rate was 3.4% on ldioscopus clypealis, 0.26% on l. niveosparsus and 0.4% on Bakera nigrobilineata. The one-year survey was conducted in 2013.

The male H. fulmeki exhibited monoparasitism and superparasitism on l. clypealis (Lethierry), and l. niveosparsus (Lethierry) but exhibited only monoparasitism on B. nigrobilineata (Melichar). Meanwhile, the female H. fulmeki parasitized only l. clypealis and together with an unidentified female Halictophagus sp. multiparasitized l. clypealis. The female C. philippines parasitized l. niveosparsus alone or, together with male H. fulmeki.

Superparasitism by female H. fulmeki on l. clypealis positively and strongly correlated with temperature, while superparasitism by the combined male and female H. fulmeki on female l. clypealis positively correlated with the density of hoppers. Monoparasitism by male H. fulmeki and by female C. philippines on male l. niveosparsus was also positively and strongly correlated with the density of hoppers. Temperature and flowering of mango trees exerted a positive influence on the population density of the two (2) species of ldioscopus, but had no effect on 8. nigrobilineata.

The parasitoids were initially collected in 1994 and have since been among the natural control factors that regulate MLH populations. How to enhance the level of parasitism by the parasitoids is an important research area to pursue.
Past and present patterns of family formation in Eastern Europe: Does Hajnal’s delineation still matter?
Authors: Puur Allan , Maslauskaitė Aušra , Rahnu Leen , Stankūnienė Vlada
Published: January 2025

This article explores the link between historical and contemporary patterns of family formation. The theoretical underpinnings of the study were derived from Hajnal’s theory of historical nuptiality regimes in Europe. In general, the results suggest that all countries in the region share a common vector of changes in partnership formation, but at the same time the onset and advancement of these changes varies. The changesstarted earlier and have advanced further in countries that had experienced the western European marriage pattern in the past, and they began later and are less advanced in the countries with the historical eastern European marriage pattern.
Lietuvos profesinių sąjungų sektoriaus centralizacija ir koncentracija
Authors: Krašenkienė Asta
Published: January 2025

Lietuvos profesinės sąjungos pasižymi menku mokslinio pažinimo lygiu: trūksta duomenų apie sąjungų narystę, veiklą, sektoriaus sandarą ir esmines problemas. Apibūdinant įvairių šalių sąjungas, dažnai analizuojami sektoriaus sandaros aspektai, atspindintys sąjungų pasiskirstymą, organizavimą. Sandara tyrinėjama įvertinant santykinius dydžius, skaičiuojant centralizacijos ir koncentracijos, fragmentacijos indeksus. Apskaičiuoti indeksai rodo gana ryškią Lietuvos profesinių sąjungų sektoriaus decentralizaciją, aukštą koncentraciją tarp nacionalinių centrų, todėl konkurencija nėra didelė. Tačiau įvertinus apytikslę nepriklausomų sąjungų santykinę dalį, koncentracijos indeksas rodo išaugusią konkurenciją. Absoliučia vidine konkurencija pasižymi daugiau nei du trečdalius profesinių sąjungų nacionalinių centrų narių vienijanti Lietuvos sąjunga. Tokia situacija, tikėtina, nėra palanki sąjungos, kaip centralizuotos jėgos, įvaizdžiui derybose su kitais industrinių santykių (IS) dalyviais.
Políticas de Propiedad Intelectual en Universidades Públicas de Paraguay: Impacto en la Innovación y Transferencia de Tecnología
Authors: Griffith Maldonado Gladys Rossana
Published: January 2025

Este artículo de revisión explora el estado actual de las políticas de propiedad intelectual (PI) en universidades públicas de Paraguay, examinando su rol en la promoción de la innovación y la transferencia de tecnología hacia la industria. A través de un análisis documental de fuentes secundarias, se identifican y describen las políticas de PI vigentes y se evalúa su influencia en la generación de patentes y otros derechos de PI, así como en la colaboración con el sector productivo. Se discuten los desafíos específicos que enfrentan estas instituciones en un contexto de bajos niveles de inversión en investigación y desarrollo y se proponen recomendaciones para optimizar la gestión de la PI en las universidades públicas, con el objetivo de fortalecer su impacto en el desarrollo tecnológico y social del país.
Estrés y factores psicosociales en docentes de educación primaria
Authors: Rodríguez López Esteban Eduardo , Rodríguez López Isaac Abraham , Gómez Ortiz Jazmín , Huizar Nava Adrian Ernesto , Vaca Ruiz Juan José
Published: January 2025

El estrés laboral es un fenómeno en aumento, especialmente en profesiones con alta responsabilidad y contacto directo con personas. Esta investigación se enfocó en el análisis del estrés laboral en docentes de educación en primarias de la zona escolar 053 en Mexicali, Baja California, con el objetivo investigar la relación entre estrés docente y factores psicosociales en docentes de nivel primaria. Este estudio, de enfoque cuantitativo, se llevó a cabo con una muestra de 81 docentes que laboran en ambos turnos (matutino y vespertino), en escuelas primarias públicas. A través de cuestionarios estructurados, se recopilaron datos sobre las condiciones de trabajo, las demandas emocionales y físicas, así como el impacto que estas tienen en su bienestar psicológico y emocional. Los resultados preliminares sugieren que una combinación de carga laboral excesiva, falta de recursos, y la presión por cumplir las expectativas académicas son los principales factores desencadenantes del estrés laboral. Esta investigación busca contribuir a la comprensión del estrés laboral en el sector educativo y servir como base para la implementación de políticas y estrategias que mejoren las condiciones laborales de los docentes, promoviendo un ambiente de trabajo más saludable y equilibrado.
Caminos feministas hacia la comprensión holista de la opresión. Una puesta en diálogo entre Iris Marion Young y los feminismos descoloniales
Authors: Calvo Rivera Érika
Published: January 2025

Este texto plantea un rastreo expositivo por dos de las principales propuestas de construcción de un feminismo marxista formuladas a lo largo del siglo XX. Se señala, por un lado, las teorías del sistema dual, partidarias, de la mano de Heidi Hartmann, de la conceptualización independiente del patriarcado y del capitalismo. Se destaca, por el otro, la teoría unitaria defendida por Iris Marion Young, quien caracteriza ambos sistemas de opresión bajo el paraguas de un solo «patriarcado capitalista». La presentación de este debate es llevada a cabo con el propósito de fundamentar la tesis que aquí sostengo, a saber: que la conceptualización del complejo patriarcado capitalista constituye uno de los primeros intentos que se habrían enarbolado desde los feminismos en aras de comprender de manera holística los distintos ejes de dominación social. El interés que, si bien desde genealogías-otras, los feminismos descoloniales muestran en esta misma empresa legitima la puesta en diálogo que aquí realizo entre estas distintas tradiciones del feminismo.
¿Un acto de terrorismo feminista? Revisión crítica de Nyaka en las primeras Jornades Catalanes de la Dona (1976)
Authors: Rubio Mazkiaran Jone
Published: January 2025

El año 1976, en el contexto de las Jornades Catalanes de la Dona, el colectivo teatral Nyaka performó un acto abiertamente conocido por la historiografía feminista del Estado español. Así, la siguiente investigación se centrará en los orígenes de Nyaka, para después centrarse en la acción que tuvo lugar en las jornadas feministas. Entendiendo la acción como una herramienta feminista que cuestionó el imaginario de feminidad marcado por el nacionalcatolicismo franquista, se tratará de mostrar el diálogo que esta generó en el espacio en el que se ejecutó, para lo que se incidirá en la dimensión tanto emocional como corporal del acto.
Marketing Strategy in Event Sponsorship and Social Media of PT Telkomsel Surabaya
Authors: Maulida Assyaffa , Nugroho Rusdi Hidayat
Published: January 2025

This study explores the marketing strategies employed by PT Telkomsel Surabaya through event sponsorship and social media platforms. Amidst increasing competition in the telecommunications industry, the integration of offline and online marketing strategies becomes essential to maintain brand relevance and consumer loyalty. Event sponsorship aims to enhance brand image and foster direct engagement with consumers, while social media serves as a platform to expand market reach and facilitate interactive communication. Using a qualitative case study approach, this research combines data from interviews, observations, and social media content analysis. The findings reveal that Telkomsel's collaboration with local events successfully boosts brand awareness and strengthens its community-oriented image. Meanwhile, the strategic use of Instagram and TikTok fosters customer loyalty through engaging and dynamic content. This study highlights the importance of synergizing event sponsorship and social media strategies to achieve effective marketing outcomes. Practical implications are provided for companies to innovate in their marketing efforts and adapt to evolving consumer behaviors.
La Economía de la provincia de Coclé y los créditos bancarios Años: 2018-2022
Authors: Tuñon G Edwin A
Published: January 2025

La economía de la provincia de Coclé y los créditos bancarios, ha sido  conocida en el imaginario  colectivo por una economía del sector primario y la principal actividad  la  agroindustrial  azucarera y la sal. El objetivo del artículo es caracterizar la  forma de la economía  coclesana  en cuanto importancia  del  sector de la economía  que más aporta   y actividad  económica  que  sobresale   en el producto interno bruto provincial (pib) Hay un vacío de conocimiento de las características de la economía coclesana y su actividad principal en éste periodo.  Métodos y Materiales: Diseño de las Ciencias Sociales. Tipo de   cuantitativa. La fuente de información  informes  anuales del Ministerio de Economía y Finanzas, datos   de la economía coclesana, cuentas nacionales de Instituto Nacional de Estadística y Censo, informes de  redes sociales sobre economía coclesana. Se  clasifica la información atendiendo los tres sectores de la economía: primario, secundario, terciario. Reconociendo el sector  económico que más aporta y la actividad económica más importante por generación de  riqueza, Discusión:  La economía coclesana, ha  sufrido  transformaciones importantes,  que  hacen variar  ésa realidad  del siglo pasado  con una economía del sector primario y actividad agroindustrial azucarera  y de sal. La  transformación  se evidencia en la estadística  de cuentas nacionales de la provincia de Coclé la cual en el periodo 2018-2022 del sector terciario y la principal actividad la construcción de viviendas y locales comerciales. Los créditos  se centran en la actividad terciaria. Conclusiones  La economía coclesana en el periodo 2018-2022  atendiendo la información de las  cuentas nacionales provinciales  se ha demostrado que es una economía con  el sector terciario  con créditos centrados en el sector  y la principal actividad  dentro del sector secundario lo es  la construcción.
El padre, el hijo y la hija
Authors: Sánchez Nicolás Sebastián
Published: January 2025

Las posiciones de Brandom y Millikan se comparan con respecto a sus orígenes comunes en las obras de Wilfrid Sellars y Wittgenstein. Millikan toma más seriamente los temas de “figuración” de Sellars y Wittgenstein. Brandom sigue a Sellars más de cerca en derivar la normatividad del lenguaje de la práctica social, si bien hay también indicios en Sellars de una derivación posible a partir de la teoría evolutiva. Una importante tesis común a Brandom y Millikan es que no hay representaciones sin función o “actitud”.
Reflexiones sobre la filosofía de la historiografía y el legado teórico del “narrativismo”
Authors: Acha Omar
Published: January 2025

The last 25 years have seen the consolidation of an approach to philosophy of history under the name of a “philosophy of historiography”. This philosophy involves the analysis of the procedures that make historical interpretations reasonably within an historiographic community of peers, the use of documentary evidence, the debate on inferences, and the assessment of colligatory theses. For the philosophy of historiography, particularly in the version developed by J.-M. Kuukkanen, the “narrativist” constructivism is a particular aspect within a wider comprehension of historians’ practices where the rational argumentation and the use of evidence has priority in the choice between competing interpretations by the historians’ community. The argument here developed shows that the “narrativist insight” loses of sight the critico-cultural dimension of narrativism regarding historical representations and reproduces the dualism between interpretation and epistemology that Frank Ankersmit refered to as the “dilemma of Anglo-Saxon philosophy of history”.
ETIKA PENGGUNAAN MEDIA SOSIAL SESUAI SILA KEDUA
Authors: Gita Dwi Mutia  , Mainar Fitri  , Rike Juliansari  , Eva Siti Fadilla
Published: January 2025

The increasingly massive use of social media requires special attention to the ethics carried out by its users. The second principle of Pancasila, "Just and Civilized Humanity," emphasizes the importance of respecting human values, justice and morality in social interactions, including in the digital world. In the context of social media, ethical use in accordance with the second principle includes mutual respect, maintaining good manners, and not spreading hate speech, hoaxes, or content that harms other people. Users are expected to be able to show empathy, care about the welfare of others, and uphold fairness in interactions. This research aims to analyze the importance of applying ethics based on the second principle of Pancasila in maintaining harmony and morality in the digital space, as well as the positive impact of its application on the quality of social communication.
Lomas de Casa Blanca también es Querétaro: historias de cartón y roca
Authors: Moreno Rubio Mónica Eugenia , González Velázquez Rocío
Published: January 2025

This article presents the results of a qualitative study conducted between 2021 and 2022 in the Lomas de Casa Blanca neighborhood. The general objective, grounded in the theoretical approach of local and oral history, was to explore the foundation and growth of this area through the application of hemerographic research techniques and open interviews. The study sought to describe, in the voices of the neighborhood's residents, how Lomas emerged, the conditions in which its first settlers lived, the challenges they faced, and the changes they perceive, particularly regarding gang activity, a phenomenon supposedly endogenous to the neighborhood.
THE EFFECT OF CORN SILK ETHANOL EXTRACT (Zea mays L.) ON THE BLOOD GLUCOSE LEVELS AND HISTOPATHOLOGY OF PANCREAS IN ALLOXAN-INDUCED MICE
Authors: Nessa Nessa , Ifmaily  , Wahyu Putri Sri
Published: January 2025

Diabetes Mellitus is a metabolic disorder that occurs because pancreatic cells produce insulin in small amounts. The purpose of this study was to determine the effect of giving corn silk (Stigma maydis) to alloxan-induced mice to determine the effective dose of corn silk extract that can reduce blood glucose levels in hyperglycemic mice and histopathological features. This research is an experimental type that uses 24 male white mice as experimental animals, divided into 6 groups and each group consists of 4 mice consisting of negative control, positive control, dose variation 100mg/kgBW, 200mg/kgBW, 400mg/kgBW and the comparison group (Glibenclamide 0.65mg/kgBW). The inducer used was alloxan 150 mg/kg bw. Alloxan induction was carried out for 3 days and then the test preparation was given until the 17th day. Mice's blood was taken through the lateral tail vein to see blood sugar levels. Based on the results of measuring the blood glucose levels of mice on day 17, the average value of blood glucose levels was negative control (86.25 mg/dl), positive control (223 mg/dl), dose 100 mg/kgbb (109.75 mg /dl), dose 200 mg/kgbb (103.5 mg/dl), dose 400 mg/kgbb (92.5 mg/dl), glibenclamide 0.65mg/kgbb (95 mg/dl). Based on the results of statistical data analysis, two-way ANOVA showed significantly different results (p<0.05). The results of reducing blood glucose levels that were closest to the negative control were shown by corn silk extract at a dose of 400 mg/kgbb, while histopathological observations of the pancreas after administration of ethanol extract of corn silk at a dose of 200 mg/kgbb showed the best healing in the islets of Langerhans.
Teneurs des éléments en trace dans les hétérogénités du sud katanga, /RDCongo
Authors: MABIALA MULOMBA Philippe , BULAMBO Jean Pierre , NSOSANI MVIBUDULU Christian
Published: January 2025

Résume

L’analyse par activation neutronique a été appliquée au dosage du cuivre, du cobalt et de l’uranium dans les hétérogénites provenant de l’exploitation artisanale dans certaines localités du Sud Katanga en République Démocratique du Congo.
Les teneurs trouvées montrent que ces hétérogenites sont intimement associés aux minerais de cuivre-cobaltet contiennent à des degrés divers de l’uranium pouvant susciter multiples écueils sur les plans environnemental et de la santé publique.

Mots clefs : Hétérogénites, analyse par activation, exploitation artisanale, Uranium, Sud Katanga.
What impact does social media have on Nigeria’s digital creative economy?
Authors:   Busara, Abdulrahman Salamatu , Alhaji Mohammed , Balarabe Muhammad , Emehinola Oluwadarasimi , Kabir Zeenat , Solana Doluwamu
Published: January 2025

At the start of 2023, there were 122.5 million internet users in Nigeria with internet penetration at 55.4%. More than 31.6 million Nigerians use social media, equivalent to 14.3% of the total population.

Social media, as part of the digital creative economy, has provided employment opportunities to a lot of Nigerians and served as a platform to showcase to the world the cultural richness of Nigeria. Meta created a feel good, celebratory campaign that conveyed the catalytic power of social media to empower Nigerians. The campaign was intended to make Nigerians feel proud about their culture, their hustle, and how they have created a truly unique and dynamic social media ecosystem that empowers millions. Also, the campaign was to inspire the target audience to appreciate the value of the digital creative economy. It targeted a wide range of audiences, from the average Nigerian to digital entrepreneurs and even policymakers.
DESIGN OF EXPERIMENT AND MATHEMATICAL MODEL OF BENDING STRENGTH OF SOLID WOOD PANEL
Authors: Hurem Nedim , Hodžić Damir
Published: January 2025

The aim of this paper is to present a sufficiently adequate and accurate mathematical model of the breaking force of a solid wood panel. For that purpose, an experiment with thirteen repetitions was designed and done. The input sizes that varied on three levels are the density of the wood and the thickness of the solid wood panel. Since the central composite plan with thirteen repetitions of the experiment also includes four repetitions in the marginal areas, two more wood densities and two solid wood panel thicknesses were taken. The force was measured in such a way that the plate fibers were parallel to the bending direction of the plate. The measurements were made in the laboratory of the Technical Faculty in Bihać. The significance of the model coefficients was determined using the R software and the results were presented using the Design Expert software.
TEST SAMPLING AND MONITORING OF PHYSICAL-CHEMICAL PROCESSES WITH WASTEWATER TREATMENT DEVICE
Authors: Terzić Muamer
Published: January 2025

This paper presents the results of physical - chemical wastewater parameters monitoring. In addition to these parameters, the flow of wastewater coming to the device was monitored. The obtained results were analyzed by comparing the minimum, maximum and mean values at the input and output on a quarterly and annual basis. All changes observed through sampling of technological wastewater in the sense that the fluent does not provide the required quality must be taken into account and changes made to the technical solutions in the project documentation and treatment system. The values of the load with the dispersed substance and the load with the organic substance were calculated, which confirmed that both the flow and the
concentration were important for the load of the device.
RETROSPECTIVE STUDY ON THE INFLUENCE OF THE TYPE OF PROSTHETIC MATERIAL ON THE LEVELS OF BONE RESORPTION AROUND DENTAL IMPLANTS
Authors:   “Lucian Blaga" University - Sibiu, Romania, Faculty of Medicine, Department of Dentistry and Nursing, Lixandru Cosmin Ionuț
Published: January 2025

Aim of the study: The aim of the study was to evaluate the influence and impact that types of prosthetic materials can have on levels of bone resorption around dental implants. Materials and methods: This retrospective study was conducted between January 1, 2016 and December 31, 2023 at a private dental clinic in the city of Sibiu, Romania. The realization of the study involved the detailed analysis of the medical records of the patients who came to the clinic during this period of time for complex implanto-prosthetic rehabilitation. The results of this study were obtained by the analysis of a total number of 268 implants. Results: The type of prosthetic material used in complex implanto-prosthetic restorations significantly influences the long-term evolution of this therapy. Zirconium-based restorations were found to report lower levels of bone resorption around dental implants in all planes analyzed. Conclusions Zirconium-based restorations in implant-prosthetic treatment should be chosen whenever the clinical and radiological situation allows it, as they bring a series of important advantages and can contribute to the long-term success of implant-prosthetic rehabilitation.
ENHANCED PROPERTIES AND MULTIFACETED APPLICATIONS OF POLYMETHYL METHACRYLATE (PMMA) IN MODERN MEDICINE AND DENTISTRY
Authors:   “Titu Maiorescu” University, Bucharest, Romania, Faculty of Dental Medicine, Department of Speciality Disciplines, Burcea Alexandru , Bănățeanu Andreea-Mariana ,   “Titu Maiorescu” University, Bucharest, Romania, Faculty of Dental Medicine, Department of Speciality Disciplines, Poalelungi Cristian Viorel ,   “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania, Faculty of Medicine, Department of Obstetrics and Gynecology, Forna Norina ,   Faculty of Dental Medicine, U.M.F. Grigore T.Popa Iasi, Cumpătă Cristian Niky ,   “Titu Maiorescu” University, Bucharest, Romania, Faculty of Dental Medicine, Department of Speciality Disciplines
Published: January 2025

Polymethyl methacrylate (PMMA) is a versatile polymer widely used in medical, dental, and cosmetic applications due to its impressive transparency, biocompatibility, and stability against environmental factors. This review examines recent advancements in PMMA composites aimed at enhancing biocompatibility and reducing toxicity, particularly in medical applications. Innovations include the integration of nanoparticles to improve mechanical properties and reduce bacterial colonization, as well as the development of novel composites that exhibit increased durability and enhanced cellular interactions. Additionally, the review discusses the implications of these advancements for medical and dental practices, emphasizing the importance of material selection in clinical outcomes. It also highlights the ongoing challenges and potential health risks associated with PMMA, particularly concerning its interaction with biological systems. The integration of cutting-edge research and technology in PMMA composites is crucial for developing safer, more effective medical devices and interventions, ultimately leading to better patient outcomes and broader applications in healthcare.
THE MAXILLARY SINUS COMPLICATIONS OF ORAL SURGERY
Authors: Roi Alexandra , Roi Ciprian , Bumbar Eric , Sinescu Cosmin , Rivis Mircea
Published: January 2025

Aim of the study: The study aims to evaluate the frequency of the maxillary sinus pathologies and complications occurring during and after dental extraction and dental implants placement, among which we list: maxillary sinusitis, hematomas, oedema, oro-sinus fistulas, perforation of the sinus mucosa, pushing the dental roots at the level of the maxillary sinus. Material and methods: The observational study is based on the data collected from the clinical records and radiographs taken from 80 patients of Oral and Maxillofacial Surgery Clinic Timisoara, diagnosed with various pathologies at the level of the maxillary sinus as a result of dento-alveolar surgery complications. Results The patients enrolled in the study presented different forms of sinusitis, the most common being the chronic one. Bilateral involvement of sinusitis was predominated by acute forms, while unilateral involvement was associated with chronic pathology. The first upper molar was most often involved both in the pathology of maxillary sinusitis and in accidents and surgical complications, in a percentage of 16.50% of the group of patients analysed in this study. Conclusions Postoperative complications arising from inappropriate surgical procedures can in certain situations reduce the quality of life of affected patients, therefore it is important to identify the risk factors associated with postoperative complications and eliminate them as much as possible.
COLORATION AND DISCOLORATION OF OLVEOLAR BONE AND TOOTH ENAMEL CAUSED BY MEDICATION
Authors: Levente Giurgiu Cristian , Morarasu George , Baranov Nicolae , Pogăcian-Maier Alexandra-Camelia , Sireteanu-Cucui Radu-Mircea , Pipa Cristina , Miftode Alina Monica , Stefanache Alina
Published: January 2025

Aim of the Study: This review aims to investigate the pharmacologically induced discoloration of teeth and bones, focusing on how various medications affect the coloration of tooth enamel and dentin. The study seeks to provide insight into the mechanisms behind intrinsic and extrinsic discoloration and their clinical implications.
Materials and Methods: A comprehensive literature search was conducted using databases such as PubMed, Google Scholar, and Web of Science. Keywords related to tooth discoloration and medications were used to identify relevant studies, including clinical trials and case reports published between 1990 and 2023. Studies that focused on medication-related discoloration of enamel and bone were analyzed to explore the biochemical interactions between drugs and dental tissues.
Results and Discussion: The review identified several classes of medications, including tetracyclines, fluoride, antineoplastic agents, antimalarials, and iron supplements, as primary contributors to both intrinsic and extrinsic tooth discoloration. Tetracycline binds to calcium during tooth formation, leading to permanent discoloration. Fluoride can cause enamel hypomineralization, resulting in fluorosis. Antimalarials and iron supplements cause extrinsic stains due to complex formation with enamel minerals. Treatment options range from professional cleaning and bleaching to more invasive procedures like veneers and crowns, depending on the type and severity of the discoloration.
Conclusion: Medication-induced tooth discoloration presents significant clinical challenges due to its varied mechanisms, including intrinsic staining from systemic incorporation of drugs and extrinsic staining from surface agents. Early identification of high-risk medications, preventive measures, and appropriate treatment are essential to minimize aesthetic and psychological impacts. While extrinsic stains are easier to manage, intrinsic discoloration often requires restorative approaches, such as veneers or crowns, for effective resolution.
DIFFERENT BITE CLASSES AND THEIR INFLUENCE ON BODY POSTURE: A REVIEW
Authors: Albert Cristina , Haddad Clara , Lungu Ionut Iulian , Costescu Elena , Apintiliesei Aurel , Bahrim Delia Cristina , Morarasu Cătălina Smarandita , Stefanache Alina
Published: January 2025

This review explores the relationship between dental occlusion, particularly malocclusion, and its impact on body posture, emphasizing the musculoskeletal effects of different occlusal bite classifications. Class I, II, and III malocclusions affect head, neck, and spine alignment, which can lead to musculoskeletal disorders, chronic pain, and postural imbalances. Class II (overbite) results in anterior head posture, increasing strain on the cervical spine, while Class III (underbite) causes posterior head posture, leading to compensatory stress in the spine and lower back. Research highlights the biomechanical effects of malocclusion on the temporomandibular joint (TMJ) and spine, contributing to conditions like kyphosis, lordosis, and gait abnormalities. A comprehensive search of relevant literature was conducted using databases such as PubMed and Google Scholar. This review identified a need for interdisciplinary treatment approaches combining dental, orthopedic, and physical therapy interventions to address both dental alignment and musculoskeletal health. Orthodontic treatments, such as braces and jaw surgery, help realign the jaw, reducing postural strain, while physical therapy can alleviate muscle tension and improve overall body alignment. These insights highlight the importance of integrating dental and postural treatment strategies for improved patient outcomes.
CASE PRESENTATION:FRACTURED NEEDLE IN THE PTERYGOMANDIBULAR SPACE AFTER AN INFERIOR ALVEOLAR NERVE BLOCK
Authors: Iosif Precup Alexandru , Precup Andrara , Băciuț Mihaela Felicia , Moldovan Mădălina Anca , Iorcov Raluca Ortensia , Bumbu Bogdan Andrei
Published: January 2025

Needle fracture during inferior alveolar nerve block is a very rare accident that can occur in the dental private practice. The incidence is reported to represent approximately 0,000007%. A fractured needle in the pterygomandibular area is considered an emergency so it is important to withdraw it. Although images like panoramic radiography (2D) and computed tomography (3D), are useful in the localization of the foreign body the removal can be very difficult. In this article we present the case of a 32 year old male patient, who experienced an inferior alveolar nerve block for the endodontic treatment of the tooth 47 at a private dental office. During the nerve block on the right side, a 30 G disposable needle tore and shifted posteriorly in the pterygomandibular space. We managed a successful outcome, in general anaesthesia with oro tracheal intubation. The needle removal was possible with the aid of the department of interventional radiology which provided imagistic support with guided fluoroscopy.
THE RELIABILITY OF CLEAR ALIGNERS IN RESOLVING CROWDING
Authors: Barashi Mohammed A. , Alhazmi Hesham
Published: January 2025

Aim of the study Despite advancements in clear aligner therapy, there are still limitations regarding the predictability of tooth movements. Therefore, this study aims to evaluate how reliably clear aligners can address dental crowding. Materials and methods This retrospective study evaluated the orthodontic treatment outcomes using clear aligners in a sample of 60 patients. The study included healthy adults ages 18 to 60 who had non-extraction cases of crowding. Data were collected on their demographic details and clinical variables, with statistical analyses performed to compare initial and final crowding measurements and assess the need for orthodontic refinement. Chi-square tests and logistic regression were used to analyze the data and determine significant associations, if any. Results The predictability of clear aligners in resolving crowding was 65% (n = 39). Overall, the initial mean crowding of 4.13 mm (SD = 2.0) was reduced to a final mean crowding of 0.66 mm (SD=1.1). Patients who required an interproximal reduction (IPR) alone or an IPR with arch expansion were 2.38 times more likely to need refinement compared to those who had arch expansion only. This effect is statistically significant (p-value = 0.01). Conclusions Although the level of crowding had significantly decreased by the end of the study, the crowding was not fully resolved without additional refinements. Future studies should explore targeted interventions and have longer follow-up periods to achieve the complete resolution of crowding.
STRESS RELATED ORAL MANIFESTATIONS IN A GROUP OF PATIENTS FROM CONSTANȚA COUNTY
Authors: Bustiuc Steliana-Gabriela , Briceag Raluca , Raftu Gheorghe , Sin Elena-Claudia , Caraiane Aureliana
Published: January 2025

The purpose of this article is to evaluate the frequency of oral manifestations in patients with an increased level of stress. The study group included 52 patients from Constanța who arrived for specialized consultation. The patients were examined using conventional light and a clinical diagnosis was formulated based on the examination and findings. Following the clinical examination and the correlation with the anamnesis, the following types of manifestations of the oral mucosa were diagnosed: traumatic ulcers 33.33%, burning mouth syndrome – 17.65%, xerostomia – 13.73%, recurrent aphthous stomatitis – 11.76 %, herpetic oral infection – 11.76%, oral lichen planus – 7.84% and mucocele – 5.88%. Patients aged between 40-50 years presented the most frequent traumatic ulcers of the oral mucosa - 23.08% of all detected oral lesions. The most frequently reported oral manifestations detected in the male sex are represented by: traumatic ulcers - 21.15%, burning mouth syndrome - 11.54%, herpetic infections and xerostomia - 7.69%. Oral mucocele - 3.85% and recurrent acute aphthous stomatitis - 5.77% were detected the most in the female sex. All cases of oral lichen planus were identified exclusively in female patients. Bruxism was identified in 21 patients, over half being diagnosed in men, while myofacial pain dysfunction syndrome was detected in 11 patients, of which 7 were female. Stress can be a contributing factor in the appearance of oral manifestations, among which oral lichen planus is a premalignant lesion. All oral manifestations detected in patients exposed to stress can affect the functionality of the orofacial system and the quality of life.
MOLAR INCISOR HYPOMINERALIZATION (MIH) – THERAPEUTIC OPTIONS FOR THE FIRST PERMANENT MOLARS
Authors: Bunta Olimpia , Salceanu Mihaela , Ghergie Mircea , Pastrav Mihaela , Festila Dana
Published: January 2025

Molar-incisor hypomineralization (MIH) is a highly prevalent dental pathology in young children, which affects primarily the first permanent molars and the permanent incisors. Being a developmental defect, its’ treatment must take into consideration multiple aspects like extensionand size of defect, structures affected, caries involvement, sensitivity and patient compliance and cooperation. The general recommendations imply using minimally invasive procedures that aim to protect, strengthen and preserve dental structures. As treatment options for MIH affected molars vary with case severity, all available therapeutic options from prevention to extraction must be taken into consideration in this decision making. This paper presents the documented therapeutic options of the MIH affected molars.