bluuebunny/crossref_metadata_2025 huggingface dataset:
The neurobiological mechanisms underlying the effects of exercise interventions in autistic individuals
Authors: Tu Genghong , Jiang Nan , Chen Weizhong , Liu Lining , Hu Min , Liao Bagen
Published: July 2024

Autism spectrum disorder is a pervasive and heterogeneous neurodevelopmental condition characterized by social communication difficulties and rigid, repetitive behaviors. Owing to the complex pathogenesis of autism, effective drugs for treating its core features are lacking. Nonpharmacological approaches, including education, social-communication, behavioral and psychological methods, and exercise interventions, play important roles in supporting the needs of autistic individuals. The advantages of exercise intervention, such as its low cost, easy implementation, and high acceptance, have garnered increasing attention. Exercise interventions can effectively improve the core features and co-occurring conditions of autism, but the underlying neurobiological mechanisms are unclear. Abnormal changes in the gut microbiome, neuroinflammation, neurogenesis, and synaptic plasticity may individually or interactively be responsible for atypical brain structure and connectivity, leading to specific autistic experiences and characteristics. Interestingly, exercise can affect these biological processes and reshape brain network connections, which may explain how exercise alleviates core features and co-occurring conditions in autistic individuals. In this review, we describe the definition, diagnostic approach, epidemiology, and current support strategies for autism; highlight the benefits of exercise interventions; and call for individualized programs for different subtypes of autistic individuals. Finally, the possible neurobiological mechanisms by which exercise improves autistic features are comprehensively summarized to inform the development of optimal exercise interventions and specific targets to meet the needs of autistic individuals.
A LITERATURA INFANTIL PARA A 1ª SÉRIE DO 1º GRAU NA DÉCADA DE 1980: AS INDICAÇÕES DO GUIA DE LEITURA DE 1989 ÀS ESCOLAS DE PORTO ALEGRE, RS
Authors: Porfírio Luciana Cristina
Published: July 2024

Este texto descreve e analisa as indicações de livros literários para a 1ª série do primeiro grau, publicado em 1989, presentes no Guia de Leitura (GL) para alunos de 1º e 2º Graus do Centro de Pesquisas Literárias da Pontifícia Universidade Católica (PUC-RS), considerado um corpus documental profícuo que permite inferir em que bases se dão a tríade infância, escola e Literatura Infantil (LI) na década de 1980. O referencial teórico ancorou-se nos aspectos históricos do surgimento do sentimento de infância e reforma escolar durante a ascensão da burguesia no final do século XVII e início do XVIII, as características da LI e sua relação com a temática social, origens e evolução desse movimento literário no Brasil. A leitura dos títulos recomendados levou à percepção de que a produção literária para o público infantil tem em conta as características dos leitores iniciantes, no período, tentando-se distanciar do pedagogismo, mas estrangulando aspectos literários, preocupados com uma psicologia presumida sobre a infância. Alguns obstáculos estão relacionados a um período marcado pela intensidade de produções deste tipo de literatura. A amostra descrita apresenta a literatura ofertada para crianças entre 7 e 8 anos. As Considerações Finais problematizam a literatura infantil pautada na crença da sua autossuficiência, marcada pelo psicologismo, e limitada ao mercado editorial e o elevado apelo visual sobre o linguístico.
Exploring Kainic Acid-Induced Alterations in Circular Tripartite Networks with Advanced Analysis Tools
Authors: Vinogradov Andrey , Kapucu Emre Fikret , Narkilahti Susanna
Published: July 2024

Brain activity implies the orchestrated functioning of interconnected brain regions. Typical in vitro models aim to mimic the brain using single human pluripotent stem cell-derived neuronal networks. However, the field is constantly evolving to model brain functions more accurately through the use of new paradigms, e.g., brain-on-a-chip models with compartmentalized structures and integrated sensors. These methods create novel data requiring more complex analysis approaches. The previously introduced circular tripartite network concept models the connectivity between spatially diverse neuronal structures. The model consists of a microfluidic device allowing axonal connectivity between separated neuronal networks with an embedded microelectrode array to record both local and global electrophysiological activity patterns in the closed circuitry. The existing tools are suboptimal for the analysis of the data produced with this model. Here, we introduce advanced tools for synchronization and functional connectivity assessment. We used our custom-designed analysis to assess the interrelations between the kainic acid (KA)-exposed proximal compartment and its nonexposed distal neighbors before and after KA. Novel multilevel circuitry bursting patterns were detected and analyzed in parallel with the inter- and intracompartmental functional connectivity. The effect of KA on the proximal compartment was captured, and the spread of this effect to the nonexposed distal compartments was revealed. KA induced divergent changes in bursting behaviors, which may be explained by distinct baseline activity and varied intra- and intercompartmental connectivity strengths. The circular tripartite network concept combined with our developed analysis advances importantly both face and construct validity in modeling human epilepsy in vitro.
Etiology of combined pituitary hormone deficiency: GNAO1 as a novel candidate gene
Authors: Plachy Lukas , Dusatkova Petra , Maratova Klara , Amaratunga Shenali Anne , Zemkova Dana , Neuman Vit , Kolouskova Stanislava , Obermannova Barbora , Snajderova Marta , Sumnik Zdenek , Lebl Jan , Pruhova Stepanka
Published: July 2024

Because the causes of combined pituitary hormone deficiency (CPHD) are complex, the etiology of congenital CPHD remains unknown in most cases. The aim of the study was to identify the genetic etiology of CPHD in a well-defined single-center cohort. In total, 34 children (12 girls) with congenital CPHD (growth hormone (GH) deficiency and impaired secretion of at least one other pituitary hormone) treated with GH in our center were enrolled in the study. Their median age was 11.2 years, pre-treatment height was −3.2 s.d., and maximal stimulated GH was 1.4 ug/L. Of them, 30 had central adrenal insufficiency, 27 had central hypothyroidism, ten had hypogonadotropic hypogonadism, and three had central diabetes insipidus. Twenty-six children had a midline defect on MRI. Children with clinical suspicion of a specific genetic disorder underwent genetic examination of the gene(s) of interest via Sanger sequencing or array comparative genomic hybridization. Children without a detected causal variant after the first-tier testing or with no suspicion of a specific genetic disorder were subsequently examined using next-generation sequencing growth panel. Variants were evaluated by the American College of Medical Genetics standards. Genetic etiology was confirmed in 7/34 (21%) children. Chromosomal aberrations were found in one child (14q microdeletion involving the OTX2 gene). The remaining 6 children had causative genetic variants in the GLI2, PROP1, POU1F1, TBX3, PMM2, and GNAO1 genes, respectively. We elucidated the cause of CPHD in a fifth of the patients. Moreover, our study supports the PMM2 gene as a candidate gene for CPHD and suggests pathogenic variants in the GNAO1 gene as a potential novel genetic cause of CPHD.
Tectonic factors of the formation of the modern North9Western Black Sea coast geoecosystem
Authors: LOMAKIN I.E. , SARVIROV Ye.A. , KOCHELAB V.V.
Published: July 2024

The experience of many years of research shows the high tectonic activity of the North-Western Black Sea coast (NWBSC) in the Cenozoic. Differentiated block tectonic movements have long controlled here the position of the sea level, the development of the river network (including the now underwater paleovalleys), the rates of sedimentation, the processes of bank formation, landslides and the general formation of landscapes. Tectonic factors actually determine the directions and rates of development of the modern geoecosystem of the entire NWBSC. The results of their study should be taken into account when planning and solving urgent tasks and problems of rational nature management.
Geological position of Ediacaran terrigenous rocks in the territory of the Middle Dniester region of Ukraine
Authors: NESTEROVSKYI V.A. , VOLKONSKYI O.H.
Published: July 2024

The results of summarizing literary data and own observations on the distribution of terrigenous rocks — sandstones, conglomerates, siltstones in the deposits of the Ediacaran of the Middle Dniester region are presented. Terrigenous complexes of various compositions were identified in the deposits of the Grushka Formation, which directly overlay crystalline basement rocks. Rocks of psammitic and siltstone structure in various pro- portions, thicknesses, granulometric, and mineral composition were identified in the deposits of the Mogylyiv (Olchedaiv, Lomoziv, Yampil beds), Yaryshiv (Bernashivka beds), Nahoryany (Dzhurdzhuvskabeds), Danylivka (Pylypybeds), Zharnivka (Kuleshivska beds), Krushanivka (Kryvchany, Durniakivska beds), and Studenytsia (Polyvaniv beds) formations. The Olchedaiv, Yampil, and Lomoziv sandstones are the most widespread and accessible for further research. These rocks mostly consist of quartz, feldspar-quartz composition, have a platy structure and light-yellow coloration. The thickness of the sandstones in the most complete sections reaches 25—30 m, which is economically advantageous for extraction. The next stage of the study involves selecting samples for laboratory research to refine the peculiarities of the chemical composition, texture, structure, physical-mechanical properties, as well as determining parameters for optimal use.
PECULIARITIES OF THE DEVELOPMENT OF INFORMATION CULTURE IN THE DOMESTIC SOCIETY UNDER THE CONDITIONS OF THE RUSSIAN-UKRAINIAN WAR
Authors: PRUDNYKOVA Olena
Published: July 2024

The phenomenon of information culture in the context of the Russian-Ukrainian war is analyzed. It has been proven that changes in the priorities of the development of information culture during the war are determined by the course of spiritual confrontation with the enemy, accelerated transformations of public consciousness, the peculiarities of state information policy, and the urgent need to protect the country’s information sovereignty. It is argued that under the influence of the war in Ukraine, including in the spiritual and informational space, all components of information culture are being transformed, particularly its core - the information worldview. The features of the development of the information worldview as a fundamental component of information culture are identified. It is noted that living in an information society without possessing the necessary information culture poses a danger of getting lost in both virtual and real worlds simultaneously. Personal mastery of information culture in modern society is based on theoretical knowledge about the essence, content, features, and regularities of its functioning in societies with different levels of informatization. The negative impact of informational aggression on the formation of the information culture of modern youth is demonstrated. During the war, the information culture of youth is formed and changed at an accelerated pace due to the increase in information flows of both negative and positive nature and under the influence of new information technologies. One of the main problems in the process of forming the information culture of youth in the conditions of the Russian-Ukrainian war is mastering methods of countering enemy propaganda, developing critical attitudes towards information, and having a value-based worldview barrier to countering fake and anti-Ukrainian narratives. The role of knowledge and the education system in the formation of the information culture of Ukrainian society is revealed.
Erectile dysfunction in patients with multiple sclerosis
Authors: Lipowski Michał , Brola Waldemar
Published: July 2024

Multiple sclerosis is the most common neurological disease among young adults. Despite advances in treatment, it is still a disease inevitably leading to disability. The numerous symptoms of the disorder include sexual dysfunctions affecting up to 80% of patients which, however, are not always diagnosed and treated. They mostly affect men, and the main problem consists in achieving and maintaining an erection. This has a negative impact on mental health and impairs the quality of life. Diagnosing these disorders consists primarily in a properly taken medical history and determination of additional factors, often reversible, causing erectile dysfunction. Treating patients with multiple sclerosis and erectile dysfunction does not differ significantly from that of “healthy” patients. The most commonly used drugs are phosphodiesterase type 5 inhibitors. In the case of insufficient efficacy, other available treatments may be offered. The high prevalence of erectile dysfunction among men with multiple sclerosis should encourage neurologists to discuss this problem with their patients and, if necessary, refer them for a consultation with a urologist.
Genetic and epidemiological factors in the pathogenesis of neurodegenerative disorders
Authors: Borówka Julia , Skotnicka Ewa
Published: July 2024

The aim of this study was to present the current knowledge on the aetiopathogenesis of neurodegenerative disorders, devoting attention not only to neurophysiological and clinical aspects, but above all to the genetic and extra-genomic conditions underlying these diseases. The dynamic development of knowledge and technological progress in medical and related sciences is resulting in changes in the demographic structure of the human population (ageing populations). One of the consequences of these changes is an increase in the incidence of neurodegenerative disorders. Neurodegenerative diseases include Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. They belong to a group of disorders whose common feature is a pathological process leading to the loss of nerve cells through apoptosis or necrosis. The aetiology of neurodegenerative diseases is multifactorial and, in addition to the involvement of genomic factors, extra-genomic mechanisms have been postulated to be involved in their aetiopathogenesis. The aetiology of numerous neurodegenerative diseases is still not fully understood. Therefore, intensive research has been ongoing for years, focusing, among other aspects, on the causes and course of such conditions. An important direction of research into the pathogenesis of neurodegenerative diseases is assessment of their potential genetic aspect. Many studies also focus on non-genomic factors, highlighting that many of them can have a significant impact on the course of these diseases.
Handy formulas for binomial moments
Authors: Skorski Maciej
Published: July 2024

Despite the relevance of the binomial distribution for probability theory and applied statistical inference, its higher-order moments are poorly understood. The existing formulas are either not general enough, or not structured and simplified enough for intended applications.
This paper introduces novel formulas for binomial moments in the form of polynomials in the variance rather than in the success probability. The obtained formulas are arguably better structured, simpler and superior in their numerical properties compared to prior works. In addition, the paper presents algorithms to derive these formulas along with working implementation in Python’s symbolic algebra package.
The novel approach is a combinatorial argument coupled with clever algebraic simplifications which rely on symmetrization theory. As an interesting byproduct asymptotically sharp estimates for central binomial moments are established, improving upon previously known partial results.
A D-vitamin-ellátottság és egyes fehérjefrakciók közötti összefüggés vizsgálata vesebetegekben
Authors: Kovács László , Horváth Eszter Dóra , Pótáriné Kispál Renáta , Lőcsei Zoltán , Kálmán Bernadette , Toldy Erzsébet
Published: July 2024

Bevezetés: A krónikus vesebetegség gyakran jár együtt súlyos
D-vitamin-hiánnyal. Kimutatása a szérum 25-hidroxi-D-vitamin-szintjének mérése
alapján történik, amelyhez a rutinban főként az immunoassay-t alkalmazzák. Ennek
hátránya, hogy az eredmény függ a minta D-vitaminkötő és egyéb fehérjéinek
szintjétől is. Célkitűzés: Egyes szérumfehérjék és a
D-vitamin-ellátottság közötti kapcsolat tanulmányozása
D3-vitamin-naiv, krónikus vesebetegekben. Módszerek:
103 beteg (30 nem dializált, 36 peritonealis dializált és 37 hemodializált)
szérumában mértük meg az összes 25-hidroxivitamin-D, a kalcium, az összfehérje,
az albumin, a D-vitaminkötő fehérje és az elektroforetikus fehérjefrakciók
szintjét. Az intakt parathormon koncentrációt 2. és 3. generációs módszerrel is
meghatároztuk. Eredmények: Elégséges D-vitamin-ellátottságot
egy esetben sem igazoltunk. A nem dializáltak 87%-a, a hemodializáltak 86%-a, a
peritonealisan dializált betegek mindegyike D-vitamin-hiányos volt. A
dializáltakban a referenciatartományon kívül eső alfa-1- (18%), béta- (22%)
globulin és az albumin/globulin hányados (19%) szignifikánsan ritkábban fordult
elő, mint a dialízisben nem részesülő esetekben, szemben a D-vitaminkötő
fehérjével (37%). A peritonealisan kezeltekben szignifikánsan alacsonyabbnak
bizonyult az összes 25-hidroxivitamin-D, kalcium és összfehérje, gamma-globulin,
albumin/globulin hányados értéke és szignifikánsan magasabbnak az
alfa-1,2-globulin és a D-vitaminkötő fehérje szintje. Csak a peritonealisan
dializált betegekben igazolódott az összes 25-hidroxivitamin-D és az intakt
parathormon között szignifikáns negatív korreláció mindkét módszerrel mérve, míg
ez a hemodializált betegek esetében csak 3. generációs módszerrel igazolódott.
Következtetés: Krónikus vesebetegekben a gyakori
D-vitamin-hiány súlyosbodik a dialízis után, különösen a peritonealisan
dializáltakban, ezért nekik nagyobb dózis D3-vitamin adása szükséges.
A magas alfa-1-globulin-szint D-vitamin-hiánnyal jár együtt mind a dializált,
mind a nem dializált esetekben. A peritonealisan dializáltakban a D-vitaminkötő
fehérje és az egyéb szérumfehérjék szintjei gyakrabban eltérnek a
referenciatartománytól, mint a hemodializáltakban. A szekunder
hyperparathyreosis kezelésében a natív D-vitamin adásának is jelentősége van. Ez
a peritonealis dialízisben mindkét intaktparathormon-módszerrel, de
hemodialízisben csak a 3. generációs módszerrel igazolódott, ezért
hemodialízisben ennek a módszernek a használata javasolt. Orv Hetil. 2024;
165(30): 1154–1165.
A klorokin és hidroxiklorokin okozta toxikus maculopathia: a diagnosztika és a terápiás irányelvek áttekintése a hazai és a nemzetközi gyakorlatban
Authors: Fodor Mariann , Lukács Miklós Ágoston , Szekanecz Zoltán , Nagy Zoltán Zsolt
Published: July 2024

Az aminokinolinok egy régóta használt gyógyszercsoport, amely napjainkban is
elengedhetetlen számos kórkép, különösen szisztémás gyulladásos kórképek
terápiájában. Az éles látásért felelős retinarész, a macula klorokin és
hidroxiklorokin által okozott toxikus károsodása már jól ismert mellékhatás volt
a múlt században is. Az ilyen gyógyszert hosszú távon szedő krónikus betegek
szemészeti szűrése azóta visszatérő kérdéskör, mely az újonnan megjelenő
evidenciák által folyamatosan megújuló vizsgálati protokollokban nyilvánul meg.
Tanulmányunkban áttekintjük a jelenleg érvényes nemzetközi irányelveket, kitérve
arra, hogy az ezekben újonnan történő változtatások milyen új adatokon
alapszanak. Ismertetjük a korszerű szemészeti szűrés műszereit (automata
látótérvizsgálat, optikaikoherencia-tomográfia [OCT], fundus-autofluoreszcencia
[FAF], multifokális elektroretinográfia [mfERG]), valamint a klorokint vagy
hidroxiklorokint szedő betegeknél azonosított rizikófaktorokat, melyek
hajlamosítanak a maculopathia kialakulására. Végezetül egy hazai viszonyokra
adaptált szűrési protokollt szeretnénk bemutatni. Orv Hetil. 2024; 165(30)
1147–1153.
Development of Technology-Based Teaching Materials in Islamic Religious Education Subjects
Authors: Suharsiwi Suharsiwi , Shofiyah Siti , Nurmulia Fatma , Setiyanti Anis , Rutska Rutska , Santiago Paulo Vitor da Silva
Published: July 2024

The purpose of this study is to describe and analyze the development of teaching materials, and the level of feasibility of using technology-based teaching materials in learning Islamic Religious Education. This research is a type of research and development (Research and Development). By using the four-D (4-D) model developed by Thiagarajan (Define, Design, Develop, and Disseminate). The results of this study, according to media and material experts, show that the teaching materials developed have very feasible criteria with an average score of 4.65, both according to media experts and material experts based on their aspect assessment. Meanwhile, according to students' responses, they have an average score of 4.25 with very decent teaching material assessment criteria. Tujuan dari penelitian ini adalah untuk mendeskripsikan dan menganalisis pengembangan bahan ajar, dan tingkat kelayakan penggunaan bahan ajar berbasis teknologi dalam pembelajaran Pendidikan Agama Islam. Penelitian ini merupakan jenis penelitian dan pengembangan (Research and Development). Dengan menggunakan model four-D (4-D) yang dikembangkan oleh Thiagarajan (Define, Design, Develop, and Disseminate). Hasil penelitian ini, menurut ahli media dan ahli materi, menunjukkan bahwa bahan ajar yang dikembangkan memiliki kriteria sangat layak dengan skor rata-rata 4,65, baik menurut ahli media maupun ahli materi berdasarkan aspek penilaian mereka. Sementara itu, menurut respon siswa, bahan ajar tersebut memiliki skor rata-rata 4,25 dengan kriteria penilaian bahan ajar yang sangat layak.
Rules and Rulers: Demanding, Commanding and Assuming Responsibility
Authors: Owens David
Published: July 2024

Directive authorities such as police officers, judges and employers demand our obedience. Demands for obedience come in two forms. First authorities issue commands meant to bind us to obey. Second authorities frequently threaten to enforce their commands by coercion, to extract obedience by force. Liberals, anarchists and others have long regarded command and coercion as being especially problematic ways of getting someone to act, as raising a question about the legitimacy of such directive authorities but it remains unclear why being ordered about is any worse than being subject to social rules, rules that require us to behave in various ways. I argue that someone who demands your obedience seeks to assume responsibility for your compliance. That is why the claims of a ruler threaten our liberty as those of binding social rules do not.
Sinergies en temps de crisi
Authors: Giménez Rodríguez Silvia
Published: July 2024

Els centres especials d'ocupació (CEO) són una fórmula de treball protegit per a persones amb discapacitat. Donen feina a la majoria de la població activa discapacitada en unes condicions d'estabilitat més bones que l'ocupació ordinària. Aquesta fórmula és molt beneficiosa quant a ocupabilitat però no sembla ser-ho tant en relació amb la inclusió social del col·lectiu. Diferents autors en mostren una limitació destacada: la segregació del col·lectiu, ja que bloquegen la incorporació del treballador discapacitat a l'ocupació ordinària. No obstant això, en èpoques de crisi econòmica com l'actual, les virtuts de l'economia de l'ocupabilitat tornen el protagonisme a la filosofia de la inclusió, més enllà de la inclusió en el mercat laboral. Aquest estudi pretén reflexionar sobre les possibles millores dels CEO, fonamentalment en la col·laboració entre ells mateixos, per crear sinergies que els ajudin a ser cada dia més rendibles i, per tant, per evitar que en perilli l'existència. Això comportarà un increment de la creació d'ocupació per a aquest col·lectiu, malgrat el decreixement en la creació de l'ocupació ordinària en tots els altres grups de la població.
Organització dels sistemes sanitaris
Authors: Guix Oliver Joan
Published: July 2024

Un espai relativament poc aprofundit en els currículums de les disciplines de les ciències de la salut és el que es refereix al coneixement del medi en què els treballadors sanitaris es mouran durant la seva vida laboral, l’organització d’aquest entorn i els determinants que condicionen el desenvolupament d'un model de política i organització sanitària en un context determinat. Amb aquesta eina pretenem donar suport als alumnes i als professionals sanitaris en el coneixement d'aquest entorn en què viuran i es desenvoluparan professionalment.
Registration of “KUULLEE” field pea (Pisum sativum L.) variety (Shiro Type) for large-scale farmers
Authors: Solomon Bekele , Chala Debela
Published: July 2024

KUULLEE (EH08027-2) field pea variety is an improved variety selected from eleven pipelines including standard check LAMMIIF during the trial was undertaken at three test locations (Gedo, Shambu, and Arjo) in randomized Complete Block Design with three replications. The study was conducted with the objectives of releasing a variety that is high yield, disease resistant, and stable than the other competent genotypes from 2016-2020 for five consecutive years. The accessions originated first from the Field Pea Center of Excellence (Holetta Agricultural Research Center). The new variety, KUULLEE (2795.23 kg ha-1) was 10.15% yield advantages over the standard check LAMMIIF (2537.5 kg ha-1). KUULLEE variety is mainly used for the “SHIRO type”. The GGE revealed that EH08027-2 or KUULLEE variety is high-yielding, stable, and moderately resistant to Blotch, Downy Mildews, and Powdery Mildews field pea disease. Therefore, the KUULLEE variety was officially released in 2021 for Western Oromia and similar agro-ecologies.
The Influence of Content Marketing Instagram on Consumer Purchase Decisions (Study at Almeera Atelier)
Authors: Al Aziz Ilham Medi , Fauziyah Azizah , Koeswandi Tika Annisa Lestari
Published: July 2024

The purpose of this research is to find out: (1) To find out how the general description related to content marketing and consumer purchasing decisions at the Almeera Atelier company (2) To determine the effect of content marketing on Almeera Atelier consumer purchasing decisions. This study uses 2 variables to test the effect, namely the independent variable, in this study is content marketing (X) and the dependent variable is purchasing decisions (Y). This study uses quantitative data analysis techniques involving 100 samples, namely followers of Almeera Atelier. The result of this research is that there is a positive and significant influence between content marketing and purchasing decisions. This is known by conducting a t-test and one-tailed test which states that there is a positive correlation or significant influence between content marketing (X) on purchasing decisions (Y) at Almeera Atelier. This means that the ability of the independent variable to explain the dependent variable is 44%, the rest is explained by other variables not discussed in this study, such as the influence of influencers, the use of paid advertising and others.
Analysis of Digital Marketing Strategy at Almeera Atelier
Authors: Nur Dini Hajah , Yusuf Ismail , Koeswandi Tika
Published: July 2024

This research was conducted in order to help optimize the digital marketing strategy implemented to be more efficient and on target. This research uses a qualitative descriptive approach with STP (Segmenting, Targeting, Positioning), Marketing Mix 7P, and SWOT analysis methods. Describes the data obtained from the research results then the conclusion is drawn to determine the digital marketing strategy that is in Almeera Atelier. Based on the results of the analysis, the researchers concluded that the digital marketing strategy that Almeera Atelier can use is to optimize social media accounts
Post-Pandemic Marketing Management Strategy Based on Fishbone Analysis in Kampung Inggris Pare, Kediri Regency
Authors: Permatasari Indah , Hidyatullah Ahmad Taufiq , Paulus Johanes Christian
Published: July 2024

This research was conducted to dig out the root causes of ineffectiveness of marketing strategies implemented in English Educational Tourism Village in Pare, Kediri Regency and find the recommendations for them, specifically post-pandemic context. This research using a qualitative descriptive method, then, analyzed using a fishbone diagram.  The result depicted English courses in Pare, Kediri did not well implement marketing strategies, specifically digitally. It was because of lacking knowledge and skills regarding business management, less capital and lacking high-quality human resources needed. In general, researchers gave some recommendations for evaluating marketing strategies such as : 1) Implementing Segmenting, Targeting, Positioning (STP) strategies, 2) Digitalizing marketing strategies 3) Gaining more capital, 4) Upscaling human resource competencies.
ANALISIS PENGGUNAAN GADGET PADA ANAK USIA DINI
Authors: Rahayu Nur Sri , Elan Elan , Mulyadi Sima
Published: July 2024

Gadgets are one of the products of modern technology that are widely used by humans, there are many benefits that can be felt from gadgets but if they are used excessively without any control, it can have a negative effect on users, especially if the user is an early age wich is an infortant age in human life. The pupose of this research is to analyzeuse gadgets by early childhood and their role in assisting the use of gadgets. This research uses an approach with the type of case study method. The results of the study show that children use gadgets to play games, watch entertainment on youtube and also to learn to read and count from the “ Aplikasi Belajar TK dan PAUD Lengkap”. Children often focus when their parent call, sometimes while when they are not given permission to play gadgets, children also seem to have problems in their speaking skills, even though the child is already 6 yeas old, many of words spoken by child still cannot be understood. In an effort made by parents to prevent negative things from using gadgets by accompanying children when using gadgets, ensuring that they do not see content that is not appropriate for the child’s age.Gadget merupakan salah satu produk hasil teknologi modern yang banyak digunakan oleh manusia. Banyak manfaat yang dapat dirasakan dari gadget akan tetapi jika penggunaannya berlebihan tanpa adanya kontrol bisa memberikan efek negative terhadap penggunanya terlebih jika penggunanya merupakan anak usia dini yang dimasa masa ini merupakan usia penting dalam kehidupan manusia. Tujuan dari penelitian ini ialah untuk menganalisis penggunaan gadget oleh anak usia dini dan peran dalam mendampingi penggunaan gadget. penelitian ini menggunakan pendekatan kualitatif dengan jenis metode studi kasus. Hasil dari penelitian diketahui bahwa anak menggunakan gadget untuk bermain game, menonton hiburan di youtube dan juga untuk belajar baca hitung dari “ Aplikasi Belajar TK dan PAUD Lengkap”. Anak sering fokus saat bermain gadget, tidak menjawab saat orang tuanya memanggil, terkadang merengek saat tidak diberi ijin untuk bermain gadget, anak juga terlihat mengalami permasalahan dalam kemampuan berbicaranya, meskipun anak sudah berusia 6 tahun tapi masih banyak dari kata-kata yang di ucapakan anak masih belum dapat di mengerti. Dalam upaya yang dilakukan orang tua untuk mencegah hal-hal negatif dari penggunaan gadget dengan cara menemani anak saat menggunakan gadget, memastikan tidak melihat konten yang tidak sesuai dengan usia anak.
Analisis Penggunaan Media Puzzle Hijaiyah untuk Keterampilan Mengenal Huruf Hijaiyah pada Anak Usia 4-5 Tahun
Authors: Yasmin Salma Anisah , Rahman Taopik , Indihadi Dian
Published: July 2024

Problems related to the skill of recognizing hijaiyah letters encountered in educational institutions for preschool age children became the background of this study. The implementation of learning activities in the introduction of hijaiyah letters should use media that can motivate children and of course can create efficient and synchronous learning implementation activities using child development. The limited use of media in schools is the cause of less diverse learning activities. The use of hijaiyah letter puzzle media can be an appropriate means in an effort to develop skills to recognize hijaiyah letters. This study aims to describe the results of the analysis of the skills to recognize hijaiyah letters for children aged 4-5 years, and to describe the results of the analysis of the benefits of using hijaiyah puzzle media on the skills of recognizing hijaiyah letters. The method used is descriptive analysis, then the data analysis used is data reduction, data visualization, and drawing/verification of data conclusions.Permasalahan terkait keterampilan mengenal huruf hijaiyah yang ditemui di lembaga pendidikan anak usia prasekolah menjadi latar belakang dari penelitian ini. Semestinya pelaksanaan kegiatan pembelajaran dalam pengenalan huruf hijaiyah menggunakan media yang dapat memotivasi anak dan tentunya dapat menciptakan kegiatan pelaksanaan pembelajaran yang efisien dan sinkron menggunakan perkembangan anak. Keterbatasan penggunaan media di sekolah, menjadi penyebab kegiatan belajar yang kurang beragam. Penggunaan media puzzle huruf hijaiyah dapat menjadi salah satu sarana yang sesuai dalam upaya mengembangkan keterampilan mengenal huruf hijaiyah. Penelittian ini bertujuan untuk mendeskripsikan hasil anaalisis keterampilan mengenal huurf hijaiyah anak usia 4-5 tahun, dan mendeskripsikan hasiil analisis manfaat manfata media puzzle huruf hijaiyah terhadap keterampilan mengenal huruf hijaiyah. Metode yang digunakan yaitu deskriptif analisis, kemudian analitis data yang digunakan adalah reduksi data, visualisasi data, dan penarikan/verifikasi kesimpulan data.
Peran Komisi Perlindungan Anak Indonesia Daerah (KPAID) dalam Melindungi Anak dalam Eksploitasi Tenaga Kerja di Bawah Umur
Authors: Sianturi Risbon , Rahman Taopik , Azizah Trie Nour
Published: July 2024

The purpose of this study is to determine how the perfomance of the role of the comission institution (KPAID) in protecting children from exploitation of underage labor. In Indonesia there are still many cases of exploitation of underage labor, with the discovery of many children who work as hawkers, clowns, beggar, etc and inappropriate working time. So this needs to be followed up by the government. The research method used is a descriptive qualitative research method. The result of this study is that the Tasikmalaya Regency KPAID institution has performed well with the discovery that this institution carriers out supervision, protection, and prevention. The Tasikmalaya Regency KAPID institution is also responsible for conducting supervision such as data collection, case acceptance, investigation and advocacy assistance. The impact of the exploitation of labor of minors is that children become moody, not good at getting along with peers, behave like adults such as saying dirty, accustomed to going home at night and prone to other crimes.Tujuan dalam penelitian ini adalah untuk mengetahui bagaimana kinerja peran lembaga komisi perlindungan anak dari eksploitasi tenaga kerja di bawah umur. Di Indonesia masih banyak terjadi kasus eksploitasi tenaga kerja anak di bawah umur, dengan ditemukannya banyak anak yang bekerja menjadi pedagang asongan, badut, pengemis, dan sebagainya dan waktu kerja yang tidak sesuai. Maka hal ini perlu ditindaklanjuti oleh pemerintah. Penelitian ini menggunakan metode kualitatif deskriptif. Hasil pada penelitian ini adalah lembaga KPAID Kabupaten Tasikmalaya sudah melakukan kinerja dengan baik dan ditemukannya bahwa lembaga ini sudah melakukan pengawasan seperti pendataan, penerimaan kasus, melakukan investigasi dan pendampingan advokasi. Akibat dari anak yang di eksploitasi di bawah umur ini adalah anak menjadi pemurung, tidak pandai bergaul dengan teman sebaya, berperilaku layaknya orang dewasa, seperti berkata kotor, terbiasa pulang malam serta rawan kejahatan lainnya.
Analisis Kemandirian Anak Usia Dini
Authors: Mahmudah Noviatun , Elan E , Mulyana Edi Hendri
Published: July 2024

Independence in children plays an important role for life as adults. Through independence, children become better prepared to face and solve problems that will be faced. Children who have high independence will easily get along with their friends, be able to make decisions for themselves, not depend on others. This article discusses the form of early childhood independence and several factors that influence early childhood independence. The purpose of writing this article is to describe the form of early childhood independence in Bulaksari Village. The method used in this research is descriptive qualitative method. The results showed that the form of independence of children in Bulaksari Village can be seen through daily activities through indicators of physical ability, self-confidence, responsibility, discipline, and being able to recognize emotions. From the results of the study it can be concluded that early childhood in Bulaksari Village has shown independence and a good level of independence.Kemandirian pada anak memegang peranan yang penting untuk kehidupan ketika dewasa. Melalui kemandirian anak menjadi lebih siap untuk menghadapi dan memecahkan permasalahan yang akan dihadapi. Anak yang memiliki kemandirian yang tinggi akan mudah bergaul dengan temannya, mampu membuat keputusan untuk dirinya, tidak bergantung kepada orang lain. Artikel ini membahas bentuk kemandirian anak usia dini dan beberapa faktor yang mempengaruhi kemandirian anak usia dini. Tujuan penulisan artikel ini adalah untuk mendeskripsikan bentuk kemandirian anak usia dini di Desa Bulaksari.  Metode yang digunakan dalam penelitian ini adalah metode kualitatif deskriptif. Hasil penelitian menunjukkan bahwa bentuk kemandirian anak di Desa Bulaksari dapat dilihat melalui aktivitas sehari-hari melalui indikator kemampuan fisik, percaya diri, bertanggung jawab, disiplin, dan mampu mengendalikan emosi. Berdasarkan hasil penelitian, disimpulkan anak usia dini di Desa Bulaksari sudah menunjukkan kemandiriannya dan taraf kemandiriannya sudah baik.
Media Flash Card untuk Menstimulasi Perkembangan Keaksaraan Awal Anak Usia Dini
Authors: Rohmah Dita Nailul , Elan Elan , Rahman Taopik
Published: July 2024

This article was written to analyze flash card media to stimulate early childhood literacy development. The research method used in this studi is a systematic literature study by capturing article from 2015 – 2023 through online searches on google and journal search sites. The result of the study show that early childhood literacy skills are very important to be stimulated as a child’s initial foundation in reading. The ability to read is important to have so that children can develop their language skill’s, be able to socialize with othe people, and as provision for children towards further education. In addition, the use of media, especially flash card or letter cards, has an important role in stimulating early childhood literacy skills. By using letter cards or flash card, children can get to know letter in a fun and interesting way. Learning methods need to be created as fun as possible so that children do not feel bored and learning takes place effectively and efficiently.Artikel ini ditulis untuk menganalisis media flash card untuk menstimulasi perkembangan keaksaraan awal anak usia 0 – 6 tahun pada masa keemasan. Dalam penelitian ini, penulis menggunakan metode studi literature atau studi kepustakaan yang sistematis dengan menjaring artikel dalam rentang tahun 2015 – 2023 melalui pencarian online di google dan situs pencarian jurnal. Hasil studi menunjukkan bahwa kemampuan keaksaraan anak usia dini sangat penting distimulasi sebagai pondasi awal anak dalam membaca. Kemampuan membaca penting dimiliki agar anak dapat mengembangkan keterampilan bahasa nya, dapat bersosialisasi dengan orang lain, serta sebagai bekal anak menuju pendidikan yang lebih lanjut. Selain itu, penggunaan media terutama flash card  atau kartu huruf memiliki peran penting dalam stimulasi kemampuan keaksaraan awal anak usia dini. dengan menggunakan kartu huruf atau flash card ini anak dapat mengenal huruf dengan menyenangkan dan menarik. Metode pembelajaran perlu diciptakan se menyenangkan mungkin agar anak tidak merasa bosan dan pembelajaran berlangsung dengan efektif dan efisien.
Türkiye'nin Kalkınma Sürecinde Emval-i Metrukenin Değerlendirilmesi (1922-1930)
Authors: Öz Onur
Published: July 2024

Gerek Kurtuluş Savaşı devam ederken gerekse savaşın sona ermesiyle birlikte Türkiye, emval-i metruke konusuna hassasiyet ve önemle eğilmiştir. Türk hükümetleri yapmış oldukları hukuki düzenlemelerle emval-i metrukenin korunması ve değerlendirilmesi yönünde önemli çalışmışlar yürütmüştür. Böylece bu malların hükümet kontrolünde tutulmasını ve korunmasını sağlamışlardır. Bu sayede bu gibi malların suiistimale uğramasının önüne geçmeye çalışmışlardır.
Savaşın sona ermesiyle birlikte ekonomik, sosyal ve kültürel alanda kalkınmak ve gelişmek isteyen Türkiye, bu hedefini gerçekleştirebilmek için emval-i metrukeye ait taşınmaz malları değerlendirme yoluna gitmiştir. Bu doğrultuda, Ermeni emval-i metrukelerinden bazı taşınmazlar bir takım kurumlara temlik ve tahsis edilmiştir. Bu kurumların başında Resmi Daireler, Belediyeler ve Özel İdareler gibi kamu kurum ve kuruluşları gelmektedir. Bundan başka Ziraat Bankası, Sanayi ve Ticaret Odaları, Borsalar ve bazı fabrikalar ile bazı hayır kurumları da bu kapsama alınmıştır. Öte yandan kültürel alana da destek olmak maksadıyla, mektepler ve diğer bazı binalar ile özellikle de yurdun çeşitli yerlerinde bulunan Türk Ocaklarının ihtiyacı için bir kısım taşınmazların tahsisi ve temliki yoluna gidilmiştir.
Cationic Biocides Tend to Embed into the Inner Layer of the Model Outer Membrane Vesicles of Gram-negative Bacteria: Computational Insights
Authors: Kholina E.G. , Kovalenko I.B. , Strakhovskaya M.G.
Published: July 2024

The outer membrane vesicles (OMVs), produced by many pathogenic bacteria, play a significant role in bacterial pathogenesis. They promote bacterial resistance to antibiotics and act as natural protective barriers. The study of OMVs is essential both for understanding the general mechanisms of bacterial pathogenicity and for the development of the antibacterial drugs. In this paper, we created model vesicle that imitate the OMVs of Gram-negative bacteria using molecular modeling techniques. To investigate the interaction of the cationic antimicrobial compounds with the outer lipopolysaccharide (LPS) monolayer and the inner phospholipid monolayer of the OMV membrane, we performed molecular dynamics simulations by placing molecules of the cationic antiseptic octenidine on the outside or inside of model vesicles. The interaction of octenidine with the outer and inner monolayer was significantly different: octenidine interacted weakly with the outer LPS surface of the model OMV, but exhibited high affinity for the phospholipids of the inner monolayer. To study the translocation of cationic antimicrobial molecules within model OMV, we performed steered molecular dynamics simulations. For all three cationic biocide molecules, antiseptic octenidine, photosensitizer octakis(cholinyl)zinc phthalocyanine, and dye methylene blue, it turned out that, along with the LPS of the outer membrane of the OMV, the phosphates of lipid A molecules represent the final barrier to their penetration into the model OMV.
La experiencia turística en los planes de estudios universitarios de Grado en Turismo
Authors: Cerezo Medina Alfonso , García Mestanza Josefa , Haro Aragú Marina
Published: July 2024

Tourism and the experience economy are closely linked. The aim of this study is to assess the extent, timing, and manner in which the tourist experience has been integrated into the curriculum of official undergraduate Tourism degrees in Spain, given that a relevant curriculum is the most crucial element of an educational program.
For this purpose, we have employed a bibliometric analysis. Through a Content Analysis of the verification reports of Tourism degrees, using ATLAS.ti v.24, we have identified a temporal disconnect between the reality of the tourism industry and its corresponding academic training. Therefore, a greater integration of the tourist experience into the curriculum is necessary. This could be particularly achieved by introducing more mandatory courses that cover this subject matter. It is recommended that universities review their study plans to more significantly incorporate the tourist experience, in line with CEDTUR's recommendations.
The significant practical implications of this research for the employability of graduates extend to the entire tourism ecosystem. It has highlighted a discrepancy between the needs of businesses and educational programs, leading to recommendations for the implementation of improvement measures in the verification reports of Tourism degrees.
Life Cyle Assessment of Activated Carbon from Waste Materials as an Adsorbent in Wastewater Treatment
Authors: Awg Razak Dayang Nurzafirah Hazirah ,   School of Civil Engineering, College of Engineering Universiti Teknologi Mara (UiTM) Shah Alam, Malaysia, Ahmad Kamal Norashikin , Lee Gooyong ,   School of Civil Engineering, College of Engineering Universiti Teknologi Mara (UiTM) Shah Alam, Malaysia,   Department of Environmental Engineering and Health Science,  Chungnam State University, Chungcheongnam-do, South Korea
Published: July 2024

Activated Carbon (AC) has been a great alternative to reduce the cost of the process in wastewater treatment plants (WWTP) but they also have several hidden impacts on the environment. The impact assessment on the waste materials from coconut shells and wood will be identified using the Life Cycle Assessment (LCA) software approach. Through the “Cradle-to-gate” approach, activated carbon made from waste materials is produced and consumed, and its eighteen environmental effects which are fine particulate matter formation, fossil resource scarcity, freshwater ecotoxicity, freshwater eutrophication, global warming, human carcinogenic toxicity, human non-carcinogenic toxicity, ionizing radiation, land use, marine ecotoxicity, marine eutrophication, mineral resource scarcity, human health, terrestrial ecosystem, stratospheric ozone depletion, terrestrial acidification, terrestrial ecotoxicity and water consumption are assessed using the LCA software. This study aims to discover whether the choice of waste material precursors from the Activated Carbon (AC) can help to minimise environmental impacts. The study evaluates the potential benefits of using waste-derived activated carbon in wastewater treatment by comparing the environmental performance of activated carbon obtained from coconut, wood, and coal. This study is based on past studies all around the world. In thirteen of the eighteen impact categories, wood has the greatest environmental impact. Coconut shells on the other hand, has the lowest total environmental impacts, ranking first or second in fifteen among the eighteen environmental categories. The findings help in making choices for environmentally friendly wastewater treatment methods by illuminating the effects of employing waste products as an alternative source of adsorbents.