bluuebunny/crossref_metadata_2025 huggingface dataset:
HEPATO-NEPHROPROTECTIVE ACTIVITY OF NIGELLA SATIVA OIL ON PARACETAMOL-INDUCED NEW ZEALAND RABBITS (ORYCTOLAGUS CUNICULUS)
Authors: Dinar Nadhira M. , Pratiwi Sheila , Kihara Rain , Paramita Nadia G. , Fathurrahman Nazilla R. , Levita Jutti
Published: November 2017

Objective: The objective of this work was to investigate the hepato-nephroprotective activity of Nigella sativa (Ranunculaceae) oil on paracetamol-induced New Zealand rabbits (Oryctolagus cuniculus).Methods: Hepato-nephroprotective activity of Nigella sativa oil was demonstrated on six groups of paracetamol-induced New Zealand rabbits (Oryctolagus cuniculus) aged 3-4 mo, three in each group (2 males, 1 female). Group I was normal control (water 1.0 ml/kg of body weight per oral), group II was negative control (water 1.0 ml/kg of body weight per oral), group III was positive control (silymarin 100 mg/kg of body weight per oral), group IV-VI were treated with Nigella sativa oil (NSO) dose of 0.5 mg/kg of body weight, 1.0 mg/kg of body weight, and 2.0 mg/kg of body weight per oral, respectively, for 15 d. At the 16th day, rabbits in group II-VI were induced with paracetamol at a dose of 600 mg/kg of body weight per oral. At the 23rd day the animals were measured for their clinical biochemistry parameters and histological examination.Results: Paracetamol administration dose of 600 mg/kg of BW resulted in the elevation of serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), and ureum-N levels of the animals, particularly in group II which was treated only with paracetamol. Normal histology of the liver defines the clear shape of the terminal hepatic venule (THV)/central vein (CV) and sinusoids, whereas that of the kidney defines clear shape of the Bowman capsule and glomerulus shape. Qualitative histological examination of the liver showed that the THV/CV in all groups was normal, however in the paracetamol-treated group, the sinusoids were dilated, necrosis and mass apoptosis were detected. Dilated sinusoids were observed in the silymarin group and in the lower and medium doses of NSO groups. In the highest dose of NSO group the THV/CV and sinusoids were normal, but a local apoptosis and fat degeneration were detected. Qualitative histological examination of the kidney indicated that there was no abnormality of the glomerulus shape, however, mass apoptosis and local necrosis of the kidney were found in the paracetamol-treated group and the silymarin-treated group. The lowest dose of the NSO-treated group showed a normal shape of glomerulus and Bowman capsule, normal apoptosis. No necrosis was observed in the rabbit’s kidney. Higher doses of NSO groups indicated a normal glomerulus shape and Bowman capsule, mass apoptosis and local necrosis.Conclusion: In this study, Nigella sativa oil could maintain the normality of the THV/CV and sinusoids in the liver of paracetamol-induced New Zealand rabbits (Oryctolagus cuniculus). Normal glomerulus shape and Bowman capsule were also confirmed in the kidney of paracetamol-induced animals.
Factors associated with long-term vertical skeletal changes induced by facemask therapy in patients with Class III malocclusion
Authors: Kwak Hee-Jong , Park Hae-Jin , Kim Yoon-Ji , Lee Dong-Yul
Published: November 2017

Objectives:

This study investigated the long-term vertical skeletal changes induced by facemask therapy in patients with Class III malocclusion and different vertical skeletal patterns.

Materials and Methods:

A total of 54 patients (20 boys and 34 girls; mean age, 7.7 ± 2.0 years) with Class III malocclusion who were successfully treated with facemask therapy were included in this study. Vertical skeletal changes (overbite depth indicator, angle between the Sella-Nasion (SN) plane and Gonion-Gnathion (GoGn) line, angle between the Frankfort horizontal (FH) plane and mandibular plane, gonial angle, and angle between the SN plane and palatal plane) were measured on lateral cephalograms from before treatment (T0) to after facemask therapy (T1) and from T0 to after retention (T2). Multivariate linear regression analysis was used to study the associations of the patients' skeletal patterns with the short-term (T0–T1) and long-term (T0–T2) vertical skeletal changes as a result of facemask therapy.

Results:

The mean treatment period of facemask therapy (T0–T1) was 1.4 ± 0.6 years, and the mean retention period (T1–T2) was 6.9 ± 2.6 years. Age at T0 was significantly correlated with vertical skeletal changes from T0 to T1. Differences in the treatment results between sexes were not significant. The angle between point A-point B line and mandibular plane to mandibular plane angle at T0 and the angle between the FH plane and mandibular plane at T0 were significant predictors for short-term and long-term changes. Changes in the Sella-Nasion-point A from T0 to T1 and from T1 to T2 significantly affected vertical changes in the short term and long term, respectively.

Conclusions:

Vertical skeletal changes as a result of facemask therapy are significantly associated with severity of the skeletal Class III malocclusion and mandibular plane angulation before treatment and the amount of forward maxillary growth during the treatment and retention periods.
CONSIDERATION OF FACTORS IN TURNAROUND REFINERY (TAR) PROJECT MANAGEMENT
Authors: Fabić Marko , Pavletić Duško , Soković Mirko
Published: November 2017

Implementation of quality management systems within different business operations are supported by several models of quality management, business excellence, etc . The best known models are EFQM, MBNQA and IPMA, on which many other applicable models are based. Most models of quality management are generic and can be applicable to a wide array of business operations. In this paper, models of quality management will be analysed that, based on their characteristics, can be modified and successfully used in refinery turnaround (TAR) projects for the purpose of quality management. TAR projects are projects with very distinctive features and the proposed considerations w ill create the basis for defining the concept of an effective quality management model in projects of that type.
CLEANING VALIDATION- PREREQUISITE OF QUALITY IN DIETARY SUPPLEMENTS
Authors: Koročok Davor J , Colic Olivera , Tršić Milanović Nada
Published: November 2017

Manufacturers of dietary supplements meet growing regulatory demands for control of the production process, with the main goal of launching a quality based product, by which they ensure user’s protection and contentment. Demand for cleaning validation represents a multidisciplinary activity that brings together experts from around the world with a common goal: to ensure the efficacy of the cleaning operation in pharmaceutical manufacturing. Main goal of this work is to describe cleaning validation process in the manufacturing sector of liquid pharmaceutical forms- that consists of syrup and spray manufacturing. Pursuant to all guidelines of the European and National regulations, cleaning validation was initiated by designing Validation plan and Risk assessment plan for the manufacturing line of liquid pharmaceutical forms. Specified processes of cleaning were used, while specific physical, chemical and microbiological parameters were followed, and the process was complimented by a Validation protocol that documented three consecutive washing c ycles; directed at three consecutive batches of the same products on that manufacturing line for sprays. Final report of the validation process is being coordinated, followed and improved by the Quality sector. This enabled validation and efficacy of the chosen cleaning processes, but certain parameters were still being followed and analysed in order to prove conformity and/or allow changes that might arise. A goal of the pharmaceutical company to produce quality and safe products is achieved by applying principles of cleaning validation, and by using and mproving established cleaning procedures.
RULE-BASED PROCESS PLANNING AND SETUP PLANNING WITH CONSIDERATIONS OF GD&T REQUIREMENTS
Authors: Šormaz Dušan , Wakhare Mayur , Arafat Nur-Ul
Published: November 2017

Computer aided process planning is a critical link between design and manufacturing. The ready process plan in integration of design and manufacturing is always important to save manufacturing time, reduction of work in progress. This paper describes a rule based intelligent process planning system which selects necessary manufacturing processes features in the metal mechanical parts. Novel feature of this system is the use of detailed GD&T specification on both process selection and setup planning modules. Process selection module selects the necessary processes for manufacturing the hole feature that depends on feature dimensions, feature precedence, and specified geometric and dimensional tolerances. Setup planning module determines the sequences of the setups of the prismatic part on the machine tools that includes clustering and sequencing of the features in setups. This module uses rules for the following steps: tool approach direction definition, setup formation based on GD&T requirements, resolution of possible cyclic setups, setup sequencing and operation sequencing in setups. Rules can generate valid setups for both 3-axis and 4-axis milling machines. The procedures are illustrated on several examples.
ROBUST ENGINEERING CASE STUDY FOR SIMULTANEOUS PARAMETER OPTIMIZATION OF A DEEP DRILLING PROCESS
Authors: Mihail Laurentiu A
Published: November 2017

The paper reflects de overall results of an experiment developed for optimising a deep peck drilling process, using an extra-long flute drill. The problem stated was the dimensional, geometrical and orientation accuracy of the holes machined by the previously mentioned machining method. The target was to improve the quality of the machined parts and to reach the maximum productivity in the same time. The optimisation method used was the Taguchi Method, with a L423 fractionated factorial array. Another important issue was to optimise several quality characteristics, simultaneously. After machining the test part on a high-speed machining flexible system, the parts were measured on a coordinate measuring machine. Finally, the data was computed assisted by an advanced quality software. The simultaneous optimisation was achieved by validated method, through several iterations based on advanced process and design of experiments knowledge. Finally, the conclusions were compared with another results, from the same research program, validating it.
THE IMPORTANCE OF LEAN CONCEPT IN SUSTAINABLE DEVELOPMENT OF ENTERPRISES WITH SMALL SCALE PRODUCTION
Authors: Vorkapić Miloš , Ćoćkalo Dragan , Đorđević Dejan
Published: November 2017

This paper presents an algorithm that makes it possible to improve manufacturing process in an enterprise with small scale production. Today, Lean concept is more and more used in the process of improving production. Also, on the case of transmitters' production, implementation of Lean concept is analyzed based on the known principles. Credibility of the algorithm is reflected in giving recommendations on how to eliminate the short comings in the production process through transmitters: regular movement of employees, regular sequence of operations, products design, and cooperation with customers, reducing inventory and control introduction in all stages of the process. The paper gives an example of how to save material and other resources in the company.
CORPORATE SOCIAL RESPONSIBILITY IN THE HOTEL INDUSTRY
Authors: Bogetić Srđan , Antić Zorana , Lekić Snežana
Published: November 2017

The hospitality industry has been characterized by an intense growth rate enabling the development of certain world regions (mostly East Asia and the Pacific region), which until recently had poor economic perspectives. The global market conditions have necessitated their implementation of corporate social responsibility (CSR) principles aimed at promoting their competitiveness. Corporate social responsibility is no longer just a desire of certain hospitality enterprises to appreciate the environment in which they operate; it is also a business operation approach in the contemporary market. The reason for these changes is a result of the changes not only among customers, but also the market itself and the way it operates. Namely, the hospitality market has undergone major market segmentation as a result of a changed end consumer attitude towards hospitality services. In the hospitality industry, the environmental issues, such as greening, are becoming one of the major activities i n the field of CSR. The reason for the commitment of the hospitality industry to the protection of the environment lies in the fact that such a business approach leads to major cost savings in terms of water consumption saving (laundry), electricity saving, etc., which have been a great enough motive for other hotels to consider this concept
INTELLIGENT MEASURING DATA FOR PRODUCTION CONTROL
Authors: Hofmann Robert , Gröger Sophie , Fiebig Sven
Published: November 2017

According to international standardisation, the functional requirements are the basis for the specification of geometrical properties. The planning of measurements is deviated from these specifications. Furthermore, characteristics of production processes are not represented in the specifications and measurements. Therefore high risks of product quality problems are preassigned. Especially in the context of increasing digitisation and communication of production machines, the potential to control the production with help of measuring data is not prepared. Major benefits in quality as well as costs can be evolved by uncovering this potential. This paper shows a possible solution for the intelligent use of measuring data for production control. For that it is essential to create a system which starts from the functional requirements and also includes manufacturing processes properties to identify the relationship between measuring results and the process parameters. This new understanding will lead to an early planning of measurements with a higher effort at the beginning of the development process to generate effective and specific measuring data but will reduce time and costs as well as better quality at the end. That is the fundament for the industrial development and a smart production.
INTEGRATION OF CAD-RBS-FEM TECHNIQUES IN REFABRICATION OF A LATHE USED FOR PROFILING WHEELSET
Authors: Constantin George , Ghionea Adrian , Ghionea Iount , Bîșu Claudiu , Cioboată Doina
Published: November 2017

The article deals with some analysis and design stages in the frame of refabrication of a machine tool of lathe type used for profiling/re-profiling of railway wheel set. The concept enables the principle of integration of computer aided design – CAD, Rigid Body Simulation – RBS and Finite Element Modelling – FEM applied to modernization of the conventional radial and longitudinal feed drives by redesigning them in terms of integrating them with CNC equipment, reusing the machine tool structure. The drives were designed as CAD models, transferred in RBS module and also in FEM one for simulation and analysis. Some analysis stages were achieved to uniquely define the performance of a machine tool, intimate knowledge of the cutting process, elucidate the specific characteristics of the driving systems and also of the specific elements of the machines, and knowledge of static and dynamic behaviour of elastic structures, tool holders and cutting tools. The results were used for drawing conclusions regarding the design and making some recommendations related to kinematic and dynamic and also cutting parameters, for running the machine tool under appropriate conditions.
NEW LEGAL SOLUTIONS IN THE FIELD OF METROLOGY IN REPUBLIC OF SERBIA
Authors: Dujović Lucija
Published: November 2017

This paper presents an overview of new legislation in metrology in the Republic of Serbia. Particular attention is paid to the importance of legal metrology and implementation of its main goal - to convince the citizens of the accuracy of the measurement results of those measures which are used in the function of trade in goods and services, general health and safety, environmental protection, control and safety and inspection of pre -packed products.
DEVELOPMENT OF NEW TRACEABLE EUROPEAN CAPABILITIES IN THERMAL METROLOGY
Authors: Filitz Jean-Rémy , Arifovic Narcisa , Sadli Mohamed , Failleau Guillaume , Hay Bruno , Mac Lochlainn Dubaltach , Blahut Ales , Bojkovski Jovan , Hodzić Nedzadeta , Knazovicka Lenka , Milošević Nenad , Simić Slavica , Sestan Danijel , Strand Radek , Thurzo-Andras Emese , Zvizdić Davor
Published: November 2017

This paper deals with a new European project in which the overall objective is to enhance the availability of facilities in the field of thermal metrology (e.g. high temperature contact thermometry, non-contact thermometry and thermo-physical properties of materials characterisation) in European emerging National Metrology Institutes (NMIs), where access to these types of facilities is currently limited.
APPLICATION OF THE LASER SCANNING METHOD FOR CALIBRATION OF VERTICAL CYLINDRICAL TANKS
Authors: Milinković Ankica , Ristić Kornelija , Tucikešić S
Published: November 2017

Demands refers to calibration method are one of the general criteria for practice that laboratories must accomplish in terms of implementation SRPS ISO/IEC 17025:2006 standards. Method for calibration is exact technical procedure for application process of calibration, in other words it’s exact technical procedure for determination characteristics of calibrated sample. Whether it’s about nonstandard methods, modified standard or methods developed by laboratories, before official use, these methods have to proof they’re well qualified in practice these methods refers to. The International Organisation for standardization ISO, published the standard methods for calibration of horizontal and vertical cylindrical tanks, and the subject of this presentation is method that modifies standard electro – optical method of measurement internal distances in favour of 3D laser scanners that are used for making capacity tables.
OPTIMIZATION OF PRODUCTION PLAN IN THE METAL INDUSTRY BY THE USE OF DE NOVO PROGRAMMING
Authors: Babić Zoran , Perić Tunjo , Mandić Željko
Published: November 2017

Production plan optimization is one of the most important activities of the production companies in theendeavours to ensure competitive advantages. In preparing the production plan numerous factors are necessary tobe included. The problem of creating the production plan is getting more complicated when the production inputsoccur at variable prices. In this paper the application of De Novo programming model is investigated in theproduction plan optimization in the metal industry. The efficiency of the proposed model is examined on the case of acompany that produces metal containers. The obtained results indicate the high application efficiency of the modelbased on De Novo programming in the production plan optimization in the metal producing companies.
INNOVATION IN LOGISTICS SERVICES USING THE KANO MODEL
Authors: Kilibarda Milorad J
Published: November 2017

This paper presents a new approach to the innovation in logistics services based on a classification ofservice attributesdepending on how they affect customer satisfaction. A quantitative Kano model has been developed, which, unlike traditional models, describes the nonlinear relationships betweenservice attributes and customer satisfaction. The model is based on the attribute importance index and the satisfaction level. By applying the Kano model, all attributes of logistic services are classified into one of four quadrants. Depending on to which quadrant an attribute belongs, a decision on the introduction and development of innovations is being made. The aim is to introduce innovation and new logistics solutions in order to improve the attributes that are the most important to the customer, that is, which affect the customer satisfaction to the greatest extent. The model has been applied to specific research of logistics service attributes on the Serbian market, where the case study resultsindicate the importance and a high level of practical applicability of the quantitative Kano model.
INTERNATIONAL REGULATION AND STANDARDS IN FOOD SAFETY
Authors: Žikić Dragan , Stojanović Slobodan , Ušćebrka Gordana
Published: November 2017

The food production in the past period was mainly quantity-oriented. Nowadays the food production is transformed into an international System of Quality, implying production of food that has preserved its identity. This change has been caused by often incidents (Salmonella, BSE, E. coli O157:H7, dioxin), and these incidents were caused by interruption of food-safety chain. International organizations (Food and Agricultural Organization of the United Nations - FAO, World Health Organization - WHO, Office International des Epizooties - OIE, Codex Alimentarius Commission - CAC, International Organization for Standardization – ISO), on the basis of latest science acknowledgements, submitted new recommendations and standards of food-safety, with emphasis on integrated approach in development and applying of standards of food-safety as opportunity to access to global world market. By the other hand, high requests from developed countries could result in perplexity ‘standards as barriers’ and ‘standards as catalysts’ in the context of food safety standards in international trade in agricultural and food products. This paper explores the food safety concept through international regulation and food safety standards.
IMPLEMENTATION OF BUSINESS EXCELLENCE MODEL IN CLUSTER ENVIRONMENT
Authors: Morača Slobodan , Cvetković N , Fajsi Angela , Jovanović M
Published: November 2017

This paper deals with Business Excellence Model (BEM) and its implementation in cluster network environment. Total Quality Management and Organizational Excellence Model have gained a lot of attention in the last two decades as a way for organizations to meliorate business practices and operations and consequently to gain competitive edge. This paper presents the major objectives and benefits that drive companies to implement BEM. Furthermore, considering the most important barriers organizations are encountering during their endeavour to implement and apply Business Excellence Model, cluster networks, as environment that facilitates the implementation of BEM, are explained, determining the manner in which clusters help overpass the main obstacles. Since clusters imply interconnection of diverse actors which promote both knowledge creation and dissemination, innovation potential increase, resource exchange and similar, they are seen as facilitating environment for implementation for Business Excellence Model.
THE ACCURACY OF ULTRASONIC THICKNESS MEASUREMENT OF DISTORTED GRAIN STRUCTURE METAL SAMPLES
Authors: Nađ Nada , Mihaljević Morana , Keran Zdenka , Horvatić–Novak Amalija
Published: November 2017

Thickness measurement is one of the commonly used control measurements in sheet metal forming. Ultrasonic thickness measurement systems demand access to the material only from one side which makes them very useful for this purpose. Distortion of grain structure of the workpiece influences ultrasonic velocity and in that way directly influences ultrasonic thickness measurement. Three different ultrasonic thickness measurement systems are examined on the same working sample. Two systems are defined by standard EN14127. The third system is not defined by the standard and includes previously measured ultrasonic velocity in specific direction of grain elongation. Statistical analysis shows relations between measurement results obtained by all three systems and highlights the third system as the most accurate one.
Ulcerative Tinea Corporis in an Immunosuppressed patient
Authors: Paniagua Gonzalez Lizy M , Lowe Alison , Wilkerson Michael
Published: November 2017

Worldwide, Trichophyton rubrum is the most common cause of dermatophytosis. Infection is classically superficial, limited to the cornified layers of the skin, and may be accompanied by varying degrees of inflammation. Dermatophyte invasion is limited by multiple host factors, including sebum production, an intact skin barrier, and immunocompetence. We describe a 65 year old gentleman with a history of diabetes mellitus, hypertension, nephrogenic systemic fibrosis, and immunosuppressed status due to renal transplant who presented with a non-healing ulcer of the left dorsal hand. Further examination revealed palmar erythema and scale as well as annular erythematous plaques with peripheral scale on his bilateral knees. Laboratory testing yielded the diagnosis of tinea corporis, with bacterial superinfection of the left dorsal hand. The patient was started on systemic antimicrobials with complete healing of the ulcer along with total clearance of the rash. This case highlights an unusual presentation of invasive Trichophyton rubrum in the setting of immunosuppression and nephrogenic systemic fibrosis.
Basal Cell Carcinoma with Adnexal Differentiation, a Rare Entity and Challenging Histopathology Presentation. Case Report
Authors: Paniagua Gonzalez Lizy M , Shimizu Ikue
Published: November 2017

We report an 88 year-old male with a history of multiple non-melanoma skin cancers who presented for Mohs micrographic surgery with a biopsy proven infiltrative and nodular basal cell carcinoma located on the right posterior ear. During Mohs surgery, frozen sections revealed a typical nodular BCC on stage 1.   However, on stage 2, frozen section showed nodular aggregates of regular cuboidal cells with pale cytoplasm with areas mimicking multi-nucleated giant cells. Deeper permanent sections were consistent with BCC with adnexal differentiation. This histopathological presentation of basal cell carcinoma is uncommon and we sought to report the clinical and pathological features of this case.
Impact of Temperature on Injection-Related Pain Caused by Subcutaneous Administration of Ustekinumab: A Three-arm Crossover Open-label Randomized Controlled Trial
Authors: Mansouri Yasaman , Amir Yasmin , Min Michelle , Khanna Raveena , Huang Ruiqi , Suarez-Farinas Mayte , Lebwohl Mark
Published: November 2017

Background: Adherence to subcutaneous biologic agents for the treatment of psoriasis can be negatively influenced by injection pain.Objective: To explore the differences in injection site pain when patients are pre-treated with heat or cold, versus no pre-treatment prior to administration of a subcutaneous biologic agent.Methods: In an observational cohort study, patients receiving subcutaneous injections of ustekinumab were randomly assigned to receive pretreatment with ice, heat, or no intervention over three visits. Post-dose, patients rated pain on a 100 mm visual analogue scale (VAS).Results: There was an increase in the VAS score for both heat (2.51, P=0.30) and ice (3.33, P=0.16), compared to no intervention. No differences were found between the two intervention groups (-0.83, P=0.73). On average, females had the same VAS scores with ice compared to that of no intervention (-0.12, P=0.97) and a non–significant decrease of 3.29 points (P=0.38) with heat. Males had increased pain scores by 5.65 points (P=0.07) with ice and by 6.39 points (P=0.04) with heat.Limitations: Pain is a subjective measurement and objective quantification is difficult.Conclusions: On average, neither heat nor cold application reliably reduced pain. Our results do not support the application of heat or cold prior to ustekinumab injection.
Clinical Characteristics of Patients Diagnosed with Strongyloidiasis in a United States Urban Outpatient Dermatology Department: A Case Series
Authors: Watchmaker Jacqueline , Legler Sean , De Leon Dianne , Pascoe Vanessa , Stavert Robert
Published: November 2017

Background: Although considered a tropical disease, strongyloidiasis may be encountered in non-endemic regions, primarily amongst immigrants and travelers from endemic areas.  Chronic strongyloides infection may be under-detected owing to its non-specific cutaneous presentation and the low sensitivity of commonly used screening tools. Methods: 18 consecutive patients with serologic evidence of strongyloides infestation who presented to a single urban, academic dermatology clinic between September 2013 and October 2016 were retrospectively included.  Patient age, sex, country of origin, strongyloides serology titer, absolute eosinophil count, presenting cutaneous manifestations, and patient reported subjective outcome of pruritus after treatment were obtained via chart review.  Results: Of the 18 patients, all had non-specific pruritic dermatoses, 36% had documented eosinophila and none were originally from the United States. A majority reported subjective improvement in their symptoms after treatment. Conclusion:  Strongyloides infection and serologic testing should be considered in patients living in non-endemic regions presenting with pruritic dermatoses and with a history of exposure to an endemic area.Key Points:Chronic strongyloidiasis can be encountered in non-endemic areas and clinical manifestations are variableEosinophilia was not a reliable indicator of chronic infection in this case series Dermatologists should consider serologic testing for strongyloidiasis in patients with a history of exposure and unexplained pruritus
Minocycline-Induced Agranulocytosis Presenting as Ecthyma Gangrenosum
Authors: Nolan Katherine , Ishteiwy Reema , Alexis John , Zaiac Martin , Nichols Anna
Published: November 2017

A 51-year-old female with a history of rheumatoid arthritis was admitted for progressive fevers, chills and malaise. Five weeks prior, she started minocycline for an RA exacerbation. Two weeks after starting minocycline she developed an abscess on her right ankle that was treated at an urgent care facility with ceftriaxone and trimethoprim-sulfamethoxazole. She had minimal improvement so was switched to clindamycin. She developed additional abscesses on her right ankle and right axilla and spiking fevers so she was treated with incision and drainage under general anesthesia. Routine blood work obtained prior to surgery revealed severe neutropenia (0.74 103/ul) and the patient was urgently referred to the emergency department.  Skin biopsy was obtained on admission and revealed ulceration, necrosis, acute and chronic inflammation, vasculitis with vascular thrombosis and rod-shaped bacteria in blood vessel walls and lumina consistent with ecthyma gangrenosum. The following day tissue and blood cultures confirmed the growth of Pseudomonas aureginosa. Bone-marrow biopsy showed decreased granulopoiesis and hematopoiesis, and a diagnosis of minocycline-induced agranulocytosis presenting as ecthyma gangrenosum was made.  The patient had dramatic improvement with appropriate antibiotic therapy, discontinuation of minocycline and initiation of filgrastrim. She has remained healthy without recurrence for 17 months.
O DIREITO TRIBUTÁRIO COMO INSTRUMENTO PARA REDUÇÃO DA DESIGUALDADE SOCIAL: ENTRE AS LIÇÕES DE PIKETTY E O DEVER FUNDAMENTAL DE PAGAR IMPOSTOS
Authors: Andrada Antonio Carlos Suppes Doorgal de , Alvarenga Alex Da Silva
Published: November 2017

Este trabalho discorre sobre as constatações concernentes à desigualdade social apresentadas por PIKETTY (2013), na obra O Capital no Século XXI e sua compatibilidade com a realidade brasileira, conforme dados apresentados por MILÁ (2015) e pela Receita Federal (2016). Adiante, analisa-se sua proposta de redução da desigualdade através da progressividade fiscal e a compatibilidade desta com o Direito brasileiro, partindo das premissas da Constituição da República e a jurisprudência recente do Supremo Tribunal Federal, que aplicou, no julgamento conjunto das ADI’s 2.390, 2.386, 2.397 e 2.859, realizado em 2016, a teoria sobre o dever fundamental de pagar impostos NABAIS (1998).
A INCIDÊNCIA DE BENEFÍCIOS TRIBUTÁRIOS NO IPTU PARA O CONTRIBUINTE
Authors: Marcos Patrícia Rossi
Published: November 2017

O direito de propriedade com a Constituição Federal de 1988 passou a submeter-se às relações jurídicas reparatórias dos interesses individuais e difusos. O uso privado de espaços nas cidades para favorecer a necessidade da moradia passa a cumprir exigências legais. Por meio da percepção da cultura e dos hábitos da sociedade e no intuito de entender as exigências de ordenação da cidade expressas no Plano Diretor pela execução da função social da cidade, dentre as quais estruturar espaços e reservá-los para moradia. Sabe-se que os benefícios tributários e os incentivos sociais ocorrem de maneira proporcional à compreensão do cidadão para o que seja responsabilidade social. A responsabilidade pela organização do uso e ocupação do espaço produz uma lacuna aos proprietários, detentores do domínio útil e possuidores diretos de imóveis urbanos. O poder público em seus atos de gestão possui como desafio conciliar o uso da propriedade como moradia para o crescimento econômico e social sustentável. Percebe-se com a pesquisa que para a caracterização do direito comum da propriedade como moradia (dispor, reivindicar, usar e gozar), de forma genérica ou sob condições especiais e diferenciadas o recolhimento do imposto predial e territorial urbano aparece como uma obrigação ao contribuinte. Para tanto o Plano Diretor é o instrumento de intervenção municipal no espaço urbano e que impõe os limites na organização do espaço público como o dever de recolher o IPTU progressivo. Nesse sentido em favor da progressividade extrafiscal demonstra, com base em uma pesquisa empírica disposta por meio de questionário e da pesquisa doutrinária, que não só há responsabilidade pública para a transformação da cidade mas também do cidadão.
PAIKEM APPLICATION ON PROCLAMATION APPROACH OF INDONESIA’S INDEPENDENCE MATERIAL (TO INCREASE STUDY ACTIVITY AND RESULT)
Authors: Sakdiyah Siti Halimatus , Harun Harun
Published: November 2017

This article is proposed to increase activity and study result student of IPS subject  On Proclamation Approach of Indonesia’s Independence material. PAIKEM is one of active learning, innovative, creative, effective, and enjoyable. This research is Classroom Action Research (PTK) with qualitative that is done by two cycles. The kinds of data is direct data from research subject that is student of VI grade SDN Kebonsari 4 Malang. The amount is 40 students. The material of this research is “Proclamation Approach of Indonesia’s Independence”. The data collections are used observation sheet, field note, and documentation. The result of this research describe that PAIKEM increase study activity of student, this is shown from the student score on student activity instrument.  On the I cycle score value is average 75% with good enough criteria, while on the II cycle score value is average 86% with good criteria. This is shown that there is improvement of student activity. Besides that, PAIKEM also increase student activity and creativity of the study result. The study result of student is increase as long as the first cycle with average score 83%and in the last on the second cycle with average score 89%. So, it can be concluded that PAIKEM application is able to increase activity and study result of student VI grade SDN Kebonsari 4 Malang.
Penerapan Metode Usmani dalam Pembelajaran Al-Qur’an Santri TPQ Nurul Iman Garum Blitar
Authors: Hasanah Abidatul
Published: November 2017

Metode  Usmani ini sebenarnya adalah metode dari ulama’ salaf yang telah hilang, dikarenakan ada beberapa percobaan metode-metode baru yang belum pernah ada, yang mungkin bisa lebih mudah dan cepat dalam belajar membaca Al-Qur’an. Tetapi pada kenyataannya, banyak bacaan-bacaan Al-Qur’an yang masih menyalahi dan tidak sesuai dengan kaidah-kaidah tajwid. Untuk itulah penulis memilih Metode Usmani untuk dijadikan sebuah penelitian. Penelitian ini adalah kualitatif deskriptif, jenis penelitian studi kasus. Hasil penelitian menunjukkan Metode Usmani dalam pembelajaran menghafal Al-Qur’an metode ceramah, tanya jawab, latihan, eksperimen dan drill serta menggunakan teknik mengajar menggunakan Metode Usmani yaitu individual  dan klasikal.
Upaya Sekolah dalam Meningkatkan Kompetensi Guru PAI yang Belum Tersetifikasi Di MA Al-Hikmah Langkapan Srengat Blitar
Authors: Chumaida Anindhita
Published: November 2017

Tujuan dari penelitian ini adalah Untuk mengetahui upaya sekolah dalam meningkatkan kompetensi pedagogig, kepribadian, sosial, dan professional guru PAI yang belum tersertifikasi di MA Al-Hikmah Langkapan Srengat Blitar. Pendekatan dalam penelitian ini adalah metode kualitatif dengan jenis penelitian studi kasus. Hasil penelitian menunjukkan hasil bahwa Upaya sekolah adalah workshop, seminar, diklat, MGMP, supervisi konvensional, evaluasi kerja, IHT (In House Training). Pembinaan melalui kegiatan rapat dan supervisi, pembinaan dengan memberikan keteladanan. pertemuan wali murid sebagai upaya meningkatkan kemampuan berkomunikasi guru dengan orang tua siswa, rapat guru sebagai upaya meningkatkan kemampuan berkomunikasi dengan teman sejawat.
Kemampuan Komunikasi Matematis dalam Mengubah Soal Cerita menjadi Model Matematika pada Siswa Kelas VIII MTs Darussalam Kademangan Blitar
Authors: Khaini Faudjiah Nur
Published: November 2017

Tujuan penelitian dalam skripsi ini adalah (1) Mendeskripsikan kemampuan komunikasi matematis  siswa berkemampuan tinggi di kelas VIII MTs Darussalam Kademangan Blitar. (2) Mendeskripsikan  kemampuan komunikasi matematis  siswa berkemampuan sedang di kelas VIII MTs Darussalam Kademangan Blitar. (3) Mendeskripsikan kemampuan komunikasi matematis  siswa berkemampuan rendah di kelas VIII MTs Darussalam Kademangan Blitar. Pendekatan dalam penelitian ini menggunakan penelitian kualitatif. Teknik pengumpulan data yang digunakan adalah tes, wawancara, dan dokumentasi. Hasil penelitian menunjukkan siswa mampu menggunakan variabel untuk memisalkan apa yang diketahui dalam soal cerita, siswa mampu mengubah bahasa matematika menjadi model matematika, dan siswa mampu merefleksikan bahasa matematika yang terdapat dalam soal cerita
Peningkatan Hasil Belajar PKn Materi Organisasi melalui Model Numbered Head Together di Kelas V
Authors: Wahyuni Endah Tri
Published: November 2017

Penelitian peningkatan hasil belajar pendidikan kewarganegaraan melalui model Numbered Heads Together bertujuan untuk mendeskripsikan penerapan model Numbered Heads Together dalam pendidikan kewarganegaraan dengan materi organisasi dan menggambarkan peningkatan hasil belajar siswa dengan menggunakan model Numbered Heads Together. Ini akan sangat berguna bagi siswa dan guru dalam belajar. Model Numbered Heads Together juga dapat meningkatkan aktivitas guru dan siswa. Penelitian ini merupakan penelitian tindakan kelas. Hasil penelitian menunjukkan (1) Penerapan model pembelajaran Numbered Heads Together pada pembelajaran PKn dilaksanakan guru dengan baik dan sesuai dengan langkah-langkah pembelajaran Numbered Heads Together, (2) siklus I, ketuntasan belajar klasikal mengalami peningkatan sebesar 67% dengan kualifikasi cukup dan pada siklus II ketuntasan klasikal meningkat menjadi 92% dengan kualifikasi sangat baik.
Islam dalam Bingkai Ke-Indonesiaan: Toleransi Sebagai Pilar keberagamaan yang Humanis
Authors: Setiamin Setiamin
Published: November 2017

Tulisan ini mendiskusikan tentang bagaimana sikap sebagian masyarakat muslim Indonesia dalam beragama. Serta mengungkap terjadinya kesenjangan antara pesan ideal Islam dan realita yang ada. Terjadi pula oposisi antara pemahaman yang disuarakan dengan praktik yang dilakukan. Kesenjangan tersebut disebabkan oleh beberapa faktor. Tulisan ini kemudian menghasilkan kesimpulan bahwa Islam adalah agama yang menjunjung tinggi hak-hak manusia. Islam merupakan solusi atas permasalahan, bukan sumber permasalahan. Kehadiran Islam sesungguhnya untuk menyatukan umat, bukan memecah-belah kebersamaan. Dalam hal ini, toleransi menjadi solusi terpenting untuk mewujudkan kedamaian dan persaudaraan dalam bingkai kehidupan masyarakat Indonesia yang plural dan multikultural.
Menjadi Modern dan Religius: Perguruan NU di Blitar 1950an-1970an
Authors: Hakam Saiful
Published: November 2017

Kajian ini merupakan kajian pustaka. Hal yang diutamakan ialah pembacaan penuh atas buku-buku yang membahas tentang sepak terjang NU di ranah agama, politik, sosial, dan ekonomi. Selain itu, penelitian ini adalah penelitian historis.. Hasil Kajian menunjukkan perguruan NU berusaha membangun umat. Perguruan NU berusaha membangun kader-kader terbaik NU dengan cara mendidik para santri menjadi modern dan memiliki pengetahuan umum yang luas dan mendapatkan ijasah negara. Beberapa dari alumni kemudian melanjutkan pendidikan sekolah menengah hingga perguruan tinggi khususnya IAIN. Setelah lulus banyak dari mereka yang kemudian duduk sebagai birokrat di Kementerian Agama di tingkat lokal, regional, maupun pusat.
Cover Briliant Volume 2 Nomor 4, November 2017
Authors: Redaksi Dewan
Published: November 2017

Cover Briliant Volume 2 Nomor 4, November 2017
Menumbuhkan Kebiasaan Membaca Buku Pelajaran melalui Media Ular Tangga
Authors: Nur'aini Erna
Published: November 2017

Kebiasaan membaca sebenarnya berbeda dengan minat membaca.Pada kebiasaan membaca, motifnya bukan lagi hanya untuk mendapat pengalaman emosional yang mengasyik­kan tetapi juga untuk mendapat informasi atau pengetahuan baru.Permainan ular tangga merupakan salah satu alat permainan yang bisa digunakan sebagai media pembelajaran.Permainan ini dapat dimainkan untuk semua mata pelajaran dan semua jenjang kelas.Dengan permainan ular tangga ini siswa lebih termotivasi untuk membaca buku sebelum maupun sesudah pembelajaran, sehingga kebiasaan membaca buku pelajaran dapat ditumbuhkan.
CSR Disclosures in the Mining Industry: Empirical Evidence from Listed Mining Firms in Indonesia
Authors: Asmeri Rina , Alvionita Tika , Gunardi Ardi
Published: November 2017

Companies that are involved in CSR strive to meet the expectations of stakeholders. Therefore, CSR and CSR reporting are tools of legitimacy to demonstrate its obedience (legitimacy theory). This study aims to look at empirical evidence on the effect of profitability and environmental performance on CSR disclosure. This study examined the target population of mining companies listed on the Indonesian Stock Exchange that included the CSR reporting in the 2010-2014 annual report, obtained a sample of 18 companies. By using multiple regression analysis test, there is no significant influence between profitability to CSR disclosure, whilst environmental performance has effect on CSR disclosure.
Mentoring Function and Quality of Supervisor Auditor Relationship: Organizational Justice as A Mediation
Authors: Rahmawati Rahmawati , Rispantyo Rispantyo , Djamaluddin Subekti
Published: November 2017

This study empirically examines the antecedents and consequences of organization justice consisting of distributive justice, procedural justice, and interactional justice. The hypothesis of this study are mentoring function positive effect on organization justice, organizational justice positive effect on quality of supervisor-auditor relationship, mentoring function positive effect on quality of supervisor-auditor relationship. In additional, this study also hypothesized that organization justice as mediation between mentoring functions and quality of supervisor-auditor relationship. This study is a survey of 228 government internal auditors of Financial and Development Supervisory Agency-Badan Pengawasan Keuangan dan Pembangunan (BPKP) in Java-Bali Indonesia. The technique of collecting data using questionnaires. Test hypotheses using path analysis with SEM-AMOS. The results showed that mentoring function positive effect on organization justice, organizational justice positive effect on quality of supervisor-auditor relationship, mentoring function positive effect on quality of supervisor-auditor relationship. The study also provide an empirical finding that organization justice as mediation between mentoring functions and quality of supervisor-auditor relationship. The study provides recommendations to the BPKP in solving the problems faced by the government in realizing good and clean governance. This study is the first empirically examines the potential benefit of organization justice as a mediation between mentoring function and quality of supervisor-auditor relationship.
A Cognitive Diagnosis Model for Continuous Response
Authors: Minchen Nathan D. , de la Torre Jimmy , Liu Ying
Published: November 2017

Nondichotomous response models have been of greater interest in recent years due to the increasing use of different scoring methods and various performance measures. As an important alternative to dichotomous scoring, the use of continuous response formats has been found in the literature. To assess finer-grained skills or attributes and to extract information with diagnostic value from continuous response data, a multidimensional skills diagnosis model for continuous response is proposed. An expectation-maximization implementation of marginal maximum likelihood estimation is developed to estimate its parameters. The viability of the proposed model is shown via a simulation study and a real data example. The proposed model is also shown to provide a substantial improvement in attribute classification when compared to a model based on dichotomized continuous responses.
Principal Score Methods: Assumptions, Extensions, and Practical Considerations
Authors: Feller Avi , Mealli Fabrizia , Miratrix Luke
Published: November 2017

Researchers addressing posttreatment complications in randomized trials often turn to principal stratification to define relevant assumptions and quantities of interest. One approach for the subsequent estimation of causal effects in this framework is to use methods based on the “principal score,” the conditional probability of belonging to a certain principal stratum given covariates. These methods typically assume that stratum membership is as good as randomly assigned, given these covariates. We clarify the key assumption in this context, known as principal ignorability, and argue that versions of this assumption are quite strong in practice. We describe these concepts in terms of both one- and two-sided noncompliance and propose a novel approach for researchers to “mix and match” principal ignorability assumptions with alternative assumptions, such as the exclusion restriction. Finally, we apply these ideas to randomized evaluations of a job training program and an early childhood education program. Overall, applied researchers should acknowledge that principal score methods, while useful tools, rely on assumptions that are typically hard to justify in practice.
Machine Learning for Identifying Demand Patterns of Home Energy Management Systems with Dynamic Electricity Pricing
Authors: Koolen Derck , Sadat-Razavi Navid , Ketter Wolfgang
Published: November 2017

Energy management plays a crucial role in providing necessary system flexibility to deal with the ongoing integration of volatile and intermittent energy sources. Demand Response (DR) programs enhance demand flexibility by communicating energy market price volatility to the end-consumer. In such environments, home energy management systems assist the use of flexible end-appliances, based upon the individual consumer’s personal preferences and beliefs. However, with the latter heterogeneously distributed, not all dynamic pricing schemes are equally adequate for the individual needs of households. We conduct one of the first large scale natural experiments, with multiple dynamic pricing schemes for end consumers, allowing us to analyze different demand behavior in relation with household attributes. We apply a spectral relaxation clustering approach to show distinct groups of households within the two most used dynamic pricing schemes: Time-Of-Use and Real-Time Pricing. The results indicate that a more effective design of smart home energy management systems can lead to a better fit between customer and electricity tariff in order to reduce costs, enhance predictability and stability of load and allow for more optimal use of demand flexibility by such systems.