bluuebunny/crossref_metadata_2025 huggingface dataset:
ANOREXIA NERVOSA E O EFEITO NO QUADRO CLÍNICO COM O USO DOS ANTIPSICÓTICOS
Authors: Dias Rodrigues Araújo Rebeca , Porto de Melo Rodolfo , Nunes Alves de Sousa Milena
Published: November 2022

Introdução: a anorexia nervosa caracteriza-se por um transtorno alimentar com quadro clínico típico de restrição dietética e desnutrição. Objetivo: verificar a eficácia do uso dos fármacos antipsicóticos olanzapina, quetiapina, risperidona no aumento ponderal de pacientes com tal patologia. Metodologia: utilizou-se de 9 Ensaios Clínicos Randomizados (ECR) anexados na plataforma Medical Literature Analysis and Retrieval System Online/PubMed (MEDLINE), sendo todos analisados a partir de critérios de inclusão e exclusão feitos aos pares para a realização de uma Revisão Sistemática de Literatura. Resultados: os artigos foram avaliados através do sistema Grading of Recommendatons Assessment Development and Evaluaton (GRADE). Discussão: desse modo, dentre os principais achados, o antipsicótico olanzapina aparece como o mais promissor entre a risperidona e a quetiapina. O mesmo apresenta efeito positivo no aumento do Índice de Massa Corpórea (IMC) durante um menor intervalo de tempo de acordo com os Ensaios Clínicos Randomizados (ECR). Conclusões: ainda se faz necessários novos estudos para ampliar o campo de tratamento dos transtornos alimentares.

Palavras-Chave: Transtorno alimentar. Anorexia nervosa. Antipsicóticos.
The Potential Prognostic, Diagnostic and Therapeutic Targets for Recurrent Arrhythmias
in Patients with Coronary Restenosis and Reocclusions After Coronary
Stenting
Authors: Li Xia , Guo Dianxuan , Zhou Wenhang , Hu Youdong , Zhou Hualan , Chen Ying
Published: November 2022

Background:

The interplay of oxidative stress, proinflammatory microparticles, and proinflammatory cytokines in recurrent arrhythmias is unknown in elderly patients with coronary restenosis and reocclusions
after coronary stenting.

Objective:

This research sought to investigate the potential diagnostic and therapeutic targets for recurrent arrhythmias in patients with coronary restenosis and reocclusions after coronary stenting.

Methods:

We examined whether oxidative stress, proinflammatory microparticles, and proinflammatory cytokines could have effects that lead to recurrent arrhythmias in elderly patients with coronary restenosis and reocclusions. We measured the levels of malondialdehyde (MDA), CD31+
endothelial microparticle (CD31+
EMP), CD62E+
endothelial microparticle (CD62E+
EMP), high-sensitivity C-reactive protein (hs-CRP), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α), as well as
oxidized low-density lipoprotein (OX-LDL), and assessed the effects of relationship between oxidative stress,
proinflammatory microparticles, and proinflammatory cytokines on recurrent atrial and ventricular arrhythmias
in elderly patients with coronary restenosis and reocclusions after coronary stenting.

Results:

The levels of CD31+EMP, CD62E+EMP, MDA, hs-CRP, IL-1β, IL-6, IL-8, TNF-α and OX-LDL
were found to be increased significantly in coronary restenosis+recurrent atrial arrhythmia group compared to
without coronary restenosis and coronary restenosis+without recurrent atrial arrhythmia groups, respectively
(P<0.001). Patients in the coronary reocclusion+recurrent ventricular arrhythmia group also exhibited significantly increased levels of CD31+EMP, CD62E+EMP, MDA, hs-CRP, IL-1β, IL-6, IL-8, TNF-α and OX-LDL
compared to without coronary reocclusion and coronary reocclusion+without recurrent ventricular arrhythmia
groups, respectively (P<0.001).

Conclusion:

Proinflammatory microparticles, proinflammatory cytokines, and oxidative stress might act as potential targets for recurrent arrhythmias in patients with coronary restenosis and reocclusions after coronary
stenting.
Multiple Mutations on α, β and γ Domains of Streptokinase Lead to the
Generation of Highly Efficient Cysteine Analogues with Promising
Features
Authors: Mianroodi Reza Arabi , Alinodehi Narges Norouzzadeh , Behrooz Hamideh , Sabaei Milad , Nezamiha Farahnaz Khoshdel
Published: November 2022

Background:

Streptokinase, one of the most widely used thrombolytic medicines, is a
favorable protein for site-specific PEGylation as it lacks any cysteine residues in its amino acid sequence;
however, any changes in the protein’s structure should be carefully planned to avoid undesired
changes in its function.

Objectives:

This study aimed to design and produce novel di/tri-cysteine variants of streptokinase
from previously developed cysteine analogues, Arg45, Glu263, and Arg319, as candidates for multiple
site-specific PEGylation.

Methods:

Using bioinformatics tools and site-directed mutagenesis, we incorporated concurrent mutations
at Arg45, Glu263, and Arg319 (carried out in our previous study) to create di/tri-cysteine
variants of streptokinase proteins (SK45-319cys, SK263-319cys, and SK45-263-319cys) and evaluated their kinetic
activity parameters by a colorimetric method, using H-D-Val-Leu-Lys-pNA.2HCl (S2251) as substrate.

Results:

Based on the kinetic results, SK263-319cys with 44% enzyme efficiency increment compared to
wild-type SK was the superior protein in terms of activity; as well, SK45-319cys and SK45-263-319cys
showed 17 and 22% activity enhancement, respectively. Docking of the mutant streptokinase proteins
with μ-plasmin demonstrated that changes in intermolecular interactions caused by amino acid
substitution could be the reason for activity difference.

Conclusion:

The novel mutant proteins created in this study exhibit remarkable biological activity
and may be uniquely suitable for simultaneous PEGylation on two/three domains. As well, PEGylated
derivates of these variants might prove to be more proficient proteins, compared to the singlecysteine
analogs of streptokinase; because of their more surface coverage and increased molecular
weight.
Debunking the Pandemic Potential of Monkeypox Virus, a Brief Overview of the Current Surge in Monkeypox Virus Infection
Authors: Nawaz Shahid , Fatima Aiman
Published: November 2022

Monkeypox virus, a member of orthopoxviruses, has recently started to emerge in non-endemic countries worldwide, ringing the false alarms of a possible new epidemic as the world is already fighting the COVID-19 pandemic. However, there are some key differences in the nature of these two infections that require understanding by public health authorities in order to keep the masses safe from another psychological trauma, which has been previously associated with the COVID-19 pandemic. SARS-CoV-2 primarily affects the respiratory tract, whereas the monkeypox virus is mainly associated with skin lesions. Similarly, from symptoms to pathogenesis and from incubation period to treatment, both infections are not alike in many aspects. Monkeypox virus infection is self-limiting and can be treated without new vaccine interventions. Its case fatality ratio is also very low as compared to that of COVID-19. Though monkeypox virus infections can be treated easily, it can cause serious complications in immunocompromised individuals. Therefore, avoiding physical contact with infected individuals is recommended, and care must be taken in this regard.
Prevalence, Distribution and Determinants of Obesity among South African Adults with Hypertension and Diabetes
Authors: Masilela Charity , Pearce Brendon , Ongole Joven Jebio , Johnson Rabia , Adeniyi Oladele Vincent , Benjeddou Mongi
Published: November 2022

Background:

There is paucity of epidemiological data on the prevalence and determinants of obesity among South African adults with co-morbidities. This study therefore examined the prevalence, distribution, and determinants of obesity among South African adults with co-morbidities of hypertension and diabetes.

Methods:

A total of 614 South African adults attending chronic care for diabetes mellitus and hypertension were recruited. Obesity was defined as BMI ≥ 30.0kg/m2 and morbid obesity was defined as BMI ≥40 kg/m2. Multivariate logistic regression analysis was used to identify the significant determinants of obesity and morbid obesity.

Results:

Two-thirds of all participants were females [n = 461]. The overall prevalence of obesity among the study participants was 58.31%, of whom 15.15% were categorised as morbidly obese. In the multivariate logistic regression analysis, female sex [AOR=2.33; 95%CI 1.49-3.64], primary education [AOR=1.53, 95%CI 1.04-2.26], and LDL-C ≥2.6 mmol/L [AOR=0.64 95% CI 0.43-0.95] were independently associated with obesity. Also, women were almost six times more likely to be morbidly obese than men.

Conclusion:

A high prevalence of obesity attributed to sex, primary education and dyslipidaemia was found among the study participants. Aggressive and culturally sensitive obesity management and prevention strategies across the country need to be implemented to lower the incidence of cardiovascular diseases.
Screening Retinal Images and Extraction of the Retinal Blood Vessel for
Identifying Diseases and Classification of Arteries and Veins by Using
Deep Learning
Authors: Kumar K. Susheel , Yadav Shekhar , Pratap Singh Nagendra
Published: November 2022

In recent years, the extraction of retinal blood vessels from low contrast retinal images
has become a challenging task for diagnosing retinal diseases such as Diabetic Retinopathy, Agerelated
Macular Degeneration (AMD), Retinopathy of Prematurity (ROP), cataract, and glaucoma.
Another challenge is screening the retinal image to identify the disease early on. However, data
analysis from a large population-based study of retinal diseases is required to help resolve the uncertainty
in identifying the retinal disease based on retinal image classification using deep learning approaches
from the retinal diseases dataset. Therefore, we proposed the survey on the deep learning
approach for screening the retinal image to identify the early stages of the disease and discussed
retinal disease analysis based on deep learning approaches to detect Diabetic Retinopathy, AMD
ROP, and Glaucoma. We also discuss deep learning applications in the segmentation of retinal
blood vessels, extraction of the optic disc, optic cup, and fovea, and OCT segmentation to detect
retinal disease for diagnosis of diseases. Finally, discuss the classification of arteries/veins using a
deep learning approach.
Unambiguous Phase Difference Ranging Based on Short Baseline Array
Authors: Yu Tao
Published: November 2022

This chapter presents several methods of distance ranging for basic short
baseline arrays. These methods are either based on basic array positioning equations
or on basic physical definitions, but the final mathematical form of these methods is
proved to be the same. From the derivation of the ranging solution, we can see that
the one-dimensional double-base array is the basis of the plane positioning analysis.
Whether it is based on the Doppler frequency shift signal or the motion parameters, it
can be attributed to the positioning solution of the one-dimensional double-base array.
Analysis of Abstractive Text Summarization with Deep Learning Technique
Authors: Sapra Thakur Shruti J. , Kapse Avinash S.
Published: November 2022

In today's era, data in textual format has got great importance and is used to extract useful information from this data to design various kinds of information systems such as Document Generation, Prediction systems, Report Generation, Recommendation Systems, and Language modeling, and many more. That is why such techniques are very important, which will reduce the amount of data while saving the information and various parameters concerning this information. One such technique is text summarization which retains essential and useful information. This technique is very simple and convenient as compared to other techniques of summarization. For processing data, the Apache tool of Kafka is used. This platform is useful for real-time streaming data pipelines and many applications related to it. With this, one can use APIs of native Apache Kafka to populate data lakes, stream variants to and from databases, and power machine learning and analytically carry out. The input portion in this situation is a spark base platform for analytics. For the fast development of workflows for complex machine learning systems, Tensorflow is evolved as a significant library of machine learning.
Advanced Topics in Machine Learning
Authors: Zeba Sana , Alimul Haque Md. , Alhazmi Samah , Shameemul Haque
Published: November 2022

This chapter reveals the infancy of the striking experience near the “Internet of Things (IoT)”. Machine learning technology is a part of Artificial Intelligence that grew from the training of computational learning approaches and pattern recognition of artificial intelligence. Over the last few years, Machine Learning approaches have been advanced inquisitively for various sectors such as smart city, finance, banking, education, etc. Today machine learning is not similar to the previous machine learning because of various new advanced computing techniques. Machine learning technique is defined as data analysis that automates the building of analytical models. The iterative factor of learning algorithms is significant as models are uncovered to new datasets; they are skilled in autonomously adjusting. The study from earlier computations generates reliable, efficient, repeatable decisions and experiment results. Therefore, Machine Learning measures have been used to protect various smart applications from any illegal activities, threats, and various attacks. Furthermore, Machine Learning provided suitable solutions for preserving the security of various advanced applications. The patent growth rate is 34% in the machine learning field from the year 2013 to 2017, according to Patent Service IFI Claims. Also, in the world, 60% of companies are using various learning algorithms for numerous purposes. In this chapter, we have discussed efficient, advanced, and revolutionary machine learning algorithms in detail.
Keep Your Eyes on China’s Metaverse
Authors: Hung Ho Ting (Bosco)
Published: November 2022

While many people have been discussing the security implications of the development of the metaverse from a civilian or business perspective, very few discussions analyse the implications from a national security perspective. Thus, this article contributes to the security discussions by exploring how China can make use of the metaverse to maintain stability and international influence. This article argues that the metaverse provides an immersive and integrated environment, thus, facilitating the Chinese government’s spread of propaganda and invasion of the privacy of netizens accessing China’s Internet. This article will discuss China’s emphasis on Internet security; then, this article discusses how the metaverse assists China in influencing people’s mindsets and monitoring people’s behaviours. Finally, this article discusses the implication of China’s metaverse on individuals. As we sail into a new era of the digital world, everyone should maintain their independent thinking and be aware of their data security to enhance their resilience to government abuses.
A Stepped Health Services Intervention to Improve Care for Mental and Neurological Diseases: Protocol for a Prospective Cohort Trial
Authors: Pollmanns Johannes , Großgarten Karlheinz , Wolff Julia K , Nolting Hans-Dieter , Graf Clarissa , Bergmann Frank , Nelles Gereon
Published: November 2022

Background

Mental and neurological disorders cause a large proportion of morbidity burden and require adequate health care structures. However, deficits in the German health care system like long waiting times for access to specialized care and a lack of coordination between health care providers lead to suboptimal quality of care and elevated health care costs.

Objective

To overcome these deficits, we implement and evaluate a unique stepped and coordinated model of care (the Neurologisch-psychiatrische und psychotherapeutische Versorgung [NPPV] program) for patients with mental and neurological diseases.

Methods

Patients included in the program receive an appropriate treatment according to medical needs in a multiprofessional network of ambulatory health care providers. The therapy is coordinated by a managing physician and complemented by additional therapy modules, such as group therapy, internet-based cognitive behavioral therapy, and a case management. Statutory health insurance (SHI) routine data and data from a longitudinal patient survey will be used to compare the program with regular care and evaluate SHI expenditures and patient-related outcomes. A health care provider survey will evaluate the quality of structure and processes and provider satisfaction. Finally, an analysis of ambulatory claims data and drug prescription data will be used to evaluate if health care providers follow a needs-led approach in therapy. Ethics approval for this trial was obtained from the ethics committee of the chamber of physicians in North Rhine (September 13, 2017, reference No. 2017287).

Results

Patient enrollment of NPPV ended in September 2021. Data analysis has been completed in 2022. The results of this study will be disseminated through scientific publications, academic conferences, and a publicly available report to the German Federal Joint Committee, which is expected to be available in the first half of 2023.

Conclusions

The NPPV program is the first intervention to implement a stepped model of care for both mental and neurological diseases in Germany. The analysis of several data sources and a large sample size (more than 14,000 patients) enable a comprehensive evaluation of the NPPV program.

Trial Registration

German Clinical Trials Register DRKS00022754; https://tinyurl.com/3mx9pz5z.

International Registered Report Identifier (IRRID)

DERR1-10.2196/37569
The Assessment of Medical Device Software Supporting Health Care Services for Chronic Patients in a Tertiary Hospital: Overarching Study
Authors: Baltaxe Erik , Hsieh Hsin Wen , Roca Josep , Cano Isaac
Published: November 2022

Background

Innovative digital health tools are increasingly being evaluated and, in some instances, integrated at scale into health systems. However, the applicability of assessment methodologies in real-life scenarios to demonstrate value generation and consequently foster sustainable adoption of digitally enabled health interventions has some bottlenecks.

Objective

We aimed to build on the process of premarket assessment of 4 digital health interventions piloted at the Hospital Clinic de Barcelona (HCB), as well as on the analysis of current medical device software regulations and postmarket surveillance in the European Union and United States in order to generate recommendations and lessons learnt for the sustainable adoption of digitally enabled health interventions.

Methods

Four digital health interventions involving prototypes were piloted at the HCB (studies 1-4). Cocreation and quality improvement methodologies were used to consolidate a pragmatic evaluation method to assess the perceived usability and satisfaction of end users (both patients and health care professionals) by means of the System Usability Scale and the Net Promoter Score, including general questions about satisfaction. Analyses of both medical software device regulations and postmarket surveillance in the European Union and United States (2017-2021) were performed. Finally, an overarching analysis on lessons learnt was conducted considering 4 domains (technical, clinical, usability, and cost), as well as differentiating among 3 different eHealth strategies (telehealth, integrated care, and digital therapeutics).

Results

Among the participant stakeholders, the System Usability Scale score was consistently higher in patients (studies 1, 2, 3, and 4: 78, 67, 56, and 76, respectively) than in health professionals (studies 2, 3, and 4: 52, 43, and 54, respectively). In general, use of the supporting digital health tools was recommended more by patients (studies 1, 2, 3, and 4: Net Promoter Scores of −3%, 31%, −21%, and 31%, respectively) than by professionals (studies 2, 3, and 4: Net Promoter Scores of −67%, 1%, and −80%, respectively). The overarching analysis resulted in pragmatic recommendations for the digital health evaluation domains and the eHealth strategies considered.

Conclusions

Lessons learnt on the digitalization of health resulted in practical recommendations that could contribute to future deployment experiences.
How to Use the Six-Step Digital Ethnography Framework to Develop Buyer Personas: The Case of Fan Fit
Authors: Fenton Alex , Heinze Aleksej , Osborne McVal , Ahmed Wasim
Published: November 2022

Background

One of the key features of digital marketing is customer centricity, which can be applied to the domain of health. This is expressed through the ability to target specific customer segments with relevant content using appropriate channels and having data to track and understand each interaction. In order to do this, marketers create buyer personas based on a wide spectrum of quantitative and qualitative data. Digital ethnography is another established method for studying web-based communities. However, for practitioners, the complexity, rigor, and time associated with ethnographical work are sometimes out of reach.

Objective

This paper responds to the gaps in the practically focused method of using social media for digital ethnography to develop buyer personas. This paper aims to demonstrate how digital ethnography can be used as a way to create and refine buyer personas.

Methods

Using a case study of the Fan Fit smartphone app, which aimed to increase physical activity, a digital ethnography was applied to create a better understanding of customers and to create and refine buyer personas.

Results

We propose two buyer personas, and we develop a 6-step digital ethnography framework designed for the development of buyer personas.

Conclusions

The key contribution of this work is the proposal of a 6-step digital ethnography framework designed for the development of buyer personas. We highlight that the 6-step digital ethnography could be a robust tool for practitioners and academicians to analyze digital communications for the process of creating and updating data-driven buyer personas to create deeper insights into digital and health marketing efforts.
Khảo sát ảnh hưởng của các tham số bộ điều khiển fuzzy PD + I trên động cơ không đồng bộ ba pha
Authors: Nguyễn Quốc Nghĩa , Lâm Quốc Hân , Nguyễn Chí Ngôn
Published: November 2022

Bộ điều khiển vi phân tỷ lệ mờ cộng tích phân điều khiển mô hình động cơ không đồng bộ ba pha được xây dựng trong bài viết. Động cơ không đồng bộ ba pha được mô phỏng trên MATLAB®/Simulink dựa theo phương trình trạng thái trên hệ tọa độ từ thông rotor (hệ tọa độ dq). Mô phỏng với tải khác nhau và có nhiễu tác động vào hệ thống cũng như so sánh với PI và khảo sát ảnh hưởng của các tham số của bộ điều khiển vi phân tỷ lệ mờ cộng tích phân. Kết quả mô phỏng cho thấy giải pháp đề xuất đã đáp ứng tốt hơn so với bộ điều khiển PI thông thường, thời gian xác lập của hệ thống hợp lý, độ vọt lố bị triệt tiêu và sai số ngõ ra thấp. Ngoài ra, bộ điều khiển còn ổn định với nhiễu tác động vào hệ thống.
Các yếu tố ảnh hưởng đến quyết định tham gia liên kết sản xuất của nông hộ nuôi tôm thẻ chân trắng (Litopenaeus vannamei) theo mô hình thâm canh tại tỉnh Sóc Trăng
Authors: Nguyễn Thị Ngân Hà , Nguyễn Thị Kim Quyên
Published: November 2022

Nghiên cứu được thực hiện từ tháng 02-12/2021 nhằm phân tích các yếu tố ảnh hưởng đến quyết định tham gia liên kết ngang trong chuỗi cung ứng tôm thẻ chân trắng (Litopenaeus vannamei) ở Sóc Trăng. Có 75 hộ nuôi tôm thẻ chân trắng tham gia liên kết và 44 hộ nuôi riêng lẻ đã được phỏng vấn. Kết quả hồi quy nhị phân cho thấy có 9 biến ảnh hưởng đến quyết định tham gia liên kết, bao gồm diện tích nuôi, nuôi theo chứng nhận, mật độ nuôi, giá bán, khoảng cách địa lý, tỷ lệ thu nhập từ tôm/tổng thu nhập, vay vốn và số lần tham gia tập huấn làm tăng xác suất tham gia liên kết và biến lợi nhuận làm giảm xác suất tham gia liên kết. Các tổ chức liên kết sản xuất có vai trò quan trọng trong việc liên kết sản xuất, tổ chức tập huấn, vay vốn ưu đãi và tạo điều kiện áp dụng các tiêu chuẩn chứng nhận. Kết quả của nghiên cứu là nền tảng để đưa ra các...
Xác định sự hiện diện của mầm bệnh ký sinh trùng và vi khuẩn trên ếch Thái Lan (Rana sp.) bị bệnh trương bụng
Authors: Nguyễn Thị Thu Hằng , Lê Thanh Siêng , Đặng Thị Hoàng Oanh
Published: November 2022

Nghiên cứu được tiến hành nhằm tìm hiểu mầm bệnh ký sinh trùng và vi khuẩn ký sinh trên ếch (Rana sp.) bị bệnh trương bụng. Kết quả kiểm tra 110 mẫu ếch thu tại Đồng Tháp từ tháng 4/2021 đến 02/2022 cho thấy ếch bệnh thường nhiễm 9 loài trùng lông gồm Balantidium coli, B. elongatum, B. entozoon, B. honghuensis, Cepedea longa, C. magna, Opalina natalensis, O. ranarum và Zelleriella binucleata. Kết quả định danh vi khuẩn đã xác định được 77 chủng thuộc 2 loài là Aeromonas hydrophila và Pseudomonas putida. Trong đó, loài vi khuẩn P. putida có tỷ lệ nhiễm cao nhất (74%). Kết quả mô học cho thấy mô gan có biểu hiện viêm, mất cấu trúc, vùng đảo tụy xung huyết, hoại tử và mất cấu trúc. Mô thận sưng tấy, viêm mô và xung huyết. Cấu trúc ống thận và nang Bowman’s bị biến đổi, vỡ và phình to. Mô ruột có lớp biểu mô bị phá vỡ, các tế bào bị mất cấu trúc và có sự hiện diện của trùng lông. Các nếp gấp ở niêm mạc ruột bị dính lại và nhiều nơi xung huyết. Mô phổi có hiện tượng...
Tipos ideais e Teoria da Mudança: proposição de modelo de avaliação para a comunicação pública de ciência e tecnologia
Authors: de Aguiar Pereira Cibele Maria Garcia , Salles-Filho Sergio Luiz Monteiro
Published: November 2022

Trazemos para o debate científico uma questão que envolve comunicadores, cientistas, instituições e órgãos de fomento: como medir o desempenho da Comunicação Pública de Ciência e Tecnologia a partir de diferentes objetivos estratégicos? Propomos um modelo de monitoramento e avaliação para a CPCT, a partir da abordagem da Teoria da Mudança (TM) e da sugestão de tipos ideais: Informacional, Engajamento Público ou Participativo/Apropriação. Trata-se da prospecção de uma cadeia lógica que seja capaz de explicar o encadeamento do processo de comunicação envolvendo a academia e a sociedade, com o apontamento de supostos e indicadores de mensuração.
Comparative Analysis of Custard Produced from Selected Cereals (Guinea Corn, Maize, Rice and Millet)
Authors: Achimugu Solomon , Okolo Judith C. , Adaji Patricia E.
Published: November 2022

This study looked at the proximate and organolleptic qualities of custard powder produced from four different cereals (guinea corn, maize, rice and millet). Proximate result ranged between 9.95-14.05%, 1.20-2.78%, 1.10-2.31%, 4.75-5.50%, 7.96-12.88% and 66.49-70.58% for moisture, ash, crude fiber, fat, protein and carbohydrate content respectively. There was significant difference in all the parameters evaluated. Product from guinea corn and Millet compared favourably with the product produced from the conventional cereal (maize). Also, sensory result revealed the preference of consumers for guinea corn and Millet based custard to the conventional primary raw material. The study established the superiority of custard from guinea corn and millet to that produced from maize.

Keywords Custard, Maize, Guinea corn, Rice, Millet
Multiparentalidade
Authors: Federici Beatriz Moreira
Published: November 2022

A família é notadamente um instituto importante da sociedade e considera-se que foi um sujeito ativo para a sua formação. Sendo assim, necessitam ser positivadas e legisladas políticas públicas que visem sua proteção. As famílias multiparentais são novas estruturas de formação familiar decorrentes da evolução deste instituto tão importante dentro da sociedade, isto posto, devem ser amparadas e concedidos direitos que visem protegê-las. Em decisão do Supremo Tribunal Federal foi decidido o reconhecimento das famílias multiparentais, concedendo todos os direitos de reconhecimento de filiação aos pais e filhos formadores deste núcleo, com ou sem registro formal, e mesmo que concomitante ao reconhecimento de filiação biológica, entretanto, de forma jurisprudencial. Cabe aos doutrinadores o estudo dos efeitos jurídicos desse reconhecimento. Objetivo: o objetivo é destacar a existência da estrutura familiar multiparental, bem como os efeitos jurídicos decorrentes de sua formação com enfoque nos institutos da pensão alimentícia e da herança, visto a necessidade de o sistema jurídico brasileiro acompanhar e tutelar as modificações sociais. Método: foi realizada uma pesquisa exploratória pelo método indutivo, visto que analisados casos concretos e, não somente, como também uma pesquisa bibliográfica doutrinária e análises jurisprudenciais. Resultado: toda a pesquisa resultou em uma análise do Recurso Extraordinário nº 898.060, marco teórico desta pesquisa, com oentendimento dos efeitos práticos do reconhecimento da multiparentalidade na realidade brasileira.
The mediating effect of training on the relationship between performance appraisal and employee performance in the banking sector
Authors: Tomizh Hasan M. , Saadon Mohd Saiful Izwaan , Nordin Aleef Omar Shah Bin
Published: November 2022

This study aimed to examine the relationship and impact of the performance appraisal process and the training process on employee performance in various banks operating in Palestine. Therefore, the descriptive-analytical approach, using both SPSS and AMIS programs to analyze the data was used. The hypotheses proposed to be tested were verified by the research. The employees of the banks operating in Palestine formed the study population, and a total number of 260 were surveyed, and 254 questionnaires were retrieved as the study sample. The expectations and achievement theories were used to build the theoretical framework. One of the most important results of this study is that it found a strong relationship between the performance appraisal process and employee performance, and the training process and performance. It also found that the general performance of employees is positively affected by several variables, including the quality and transparency of the performance appraisal process and the efficiency of the training programs that are implemented in the banking sector in Palestine. Therefore, the researchers recommended that it is necessary to continue working on developing training programs, focusing on the quality and effectiveness of the implemented programs, not the number of outputs only, and the continuous and growing interest in the performance appraisal process
Weber’s syndrome revealing a Percheron artery infarction: a case report
Authors: Mbodji Ahmadou , Faye Ibrahima , Diop Ndeye Rokhaya , Ndiaye Moustapha
Published: November 2022

Percheron’s artery (PA) occlusion is an uncommon type of stroke
involving paramedian thalamus and/or midbrain infarction. It accounts
for 4-18% of all thalamic infarcts and 0.1-2% of all strokes. Its
clinical manifestations are variable and its mode of presentation as
Weber’s syndrome is exceptional due to the unusual clinical presentatio
Inhibition of p38MAPK signal pathway alleviates radiation-induced testicular damage
Authors: Yang Juan , Ou Xiangying , Shu Manling , Wang Jie , Zhang Xuan , Wu Zhenyu , Hao Wei , Zeng Huihong , Shao Lijian
Published: November 2022

Background and Purpose: How to prevent the damage of ionizing radiation
to testis has become an urgent problem to be solved. The present aim is
to investigate whether inhibition of p38MAPK signaling can alleviate
radiation-induced testicular damage. Experimental Approaches: HE
staining was used to measure the morphological changes of epididymis and
testis. Immunohistochemistry staining was used to assess the expression
of PLZF, SOX9, p-p38MAPK. RNA-Seq was used to profile gene expression.
The expression of Mapk14, Atf2, Ddit3 and Ap1m1 genes was detected by
qPCR. Western blotting was used to detect the protein expression of
p38MAPK and p-p38MAPK. Key Results: There was a dose-response
relationship between testicular injury and ionizing radiation. The sperm
quality was significantly decreased at 6 and 8 weeks after 6Gy of
radiation. Radiation led to the decrease of PLZF+ cells and increase of
SOX9+ cells in testis. RNA-Seq data showed radiation induced 969 genes
changed in the testis. The expression of genes related to p38MAPK signal
pathway enriched by GO was significantly increased by qPCR. The
expression of p-p38MAPK in testis was significantly increased at 4 weeks
after irradiation. SB203580 treatment increased numbers of spermatozoa,
the area and diameter of seminiferous tubules and numbers of SOX9+ cells
in irradiated mice, which were consistent with the increased sperm
movement rate and density under radiation with SB203580 administration.
Conclusions and Implications: Ionizing radiation significantly changes
testicular gene expression, in which p38MAPK signal pathway is
activated. p38MAPK inhibitor SB203580 partially alleviates the
testicular damage caused by radiation and accelerate the recovery of
sperm quality.
The role of herpesviruses and pneumocysts in infectious complications in children during liver transplantation
Authors: Pulnova N. L. , Rybalkina T. N. , Karazhas N. V. , Bosh’ian R. E. , Kornienko M. N. , Kabikova O. F. , Gabrielyan N. I. , Pashkova I. E. , Silina O. V.
Published: November 2022

Infections occupy one of the central places among the complications of transplants. The frequency of fatal infectious complications during the first twelve months after transplantation ranges from 2.6 to 51.7%. Identifying markers of opportunistic infections before transplantation will help reduce the likelihood of developing these infections after induced immunosuppression. The aim of the study was to study the role of herpesviruses and pneumocysts in the occurrence of infectious complications in children before and after liver transplantation based on the detection of markers of a number of herpesvirus infections and pneumocystosis. The article presents the results of a comprehensive examination for markers of herpesvirus infections and pneumocystosis of 70 children who were treated at the Shumakov Transplantation Research Center. It should be noted that 55 patients (78.6%) were diagnosed with infectious complications, of which 46 people (65.7%) had pneumonia. To detect IgM and IgG antibodies to herpesviruses and pneumocysts, peripheral blood serum samples were examined by enzyme immunoassay (ELISA). Detection of common HBV antigens was carried out by indirect immunofluorescence reaction (NRIF). Early antigens and reproduction of herpesviruses were detected by rapid culture method (BCM) on Vero and M-19 cell cultures for CMVI. In the event of infectious complications (pneumonia) in children who underwent related liver transplantation, the number of patients with active EBI markers increased almost 7 times and active HCV-6 markers increased 3.5 times. The paper shows the need for a broader laboratory screening of opportunistic infections, which will serve to achieve better clinical results, contribute to the formation of more advanced diagnostic algorithms, as well as improve epidemiological surveillance of these infections.
Characteristics of measles in children during the rise in incidence in 2019
Authors: Molochkova O. V. , Kovalev O. B. , Kosyreva M. A. , Ilyina N. O. , Shamsheva O. V. , Getmanova E. N. , Korsunsky A. A. , Galeeva E. V. , Guzhavina A. A.
Published: November 2022

In Moscow, as in Russia, in 2019 there was an increase in the incidence of measles in recent years.

Purpose: to analyze the course of measles in children hospitalized in 2019 during the period of rising incidence.

Materials and methods: a retrospective analysis and statistical processing of 30 case histories of children hospitalized with measles in the infectious diseases department of the Children's City Clinical Hospital № 9 named after G.N. Speransky in 2019.

Results: More than half of the patients were under the age of 3 years (53%). In 90% of cases, the sick were not vaccinated, in 73% – due to the refusal of their parents. Only 23% of patients had measles contact, mostly familial. Measles in hospitalized children proceeds typically, in 83.3% of cases in a moderate form, with characteristic pathognomonic symptoms: in 83.3% of patients, Belsky-Filatov-Koplik spots are detected, on average, on the 4.4 ± 0.8 day of illness, spotted – papular rash on the face with staged distribution and subsequent staged pigmentation in all patients. Complications develop in 66.7% of cases, more often pneumonia (36.7%) and obstructive bronchitis (20%), which in 16.7% of cases cause the severity of the course and lead to the development of emergency syndromes and conditions (respiratory failure, obstructive syndrome).

Conclusions. Failure to vaccinate against measles contributes to morbidity with possible complications.
Detection of antibodies to B. burgdorferi by enzyme immunoassay in patients with Lyme borreliosis
Authors: Sayfullin R. F. , Zvereva N. N. , Saifullin М. А. , Smetanina S. V. , Kardonova E. V. , Shamsheva O. V.
Published: November 2022

The detection of antibodies to borrelia by enzyme immunoassay (ELISA) significantly depends on the time from the onset of the disease.

Purpose: analysis of the results of antibodies determination to borrelia by ELISA in children and adults with Lyme borreliosis (LB) at various periods from the onset of the disease.

Material and methods. We conducted a retrospective, non-randomized, single-center cohort study, based on the analysis of data from 178 outpatient records of patients with a confirmed diagnosis of LB and the presence of antibody detection results by ELISA. Immunological confirmation of the diagnosis of LB was carried out by using ELISA and western blot test systems registered in the territory of the Russian Federation for the separate determination of immunoglobulins to Borrelia burgdorferi antigens of classes M and G. Results. When counting from the date of the onset of the disease, IgM and/or IgG were determined in 76% of patients at 4-6 weeks, and starting from the 7th week – in 95%. When counting from the date of tick bite, IgG with or without IgM was determined in 83% of patients starting from 7th week. At the same time, a significantly large proportion of seronegative patients among children was revealed. We have clarified the duration of antibody persistence after antibacterial therapy. In the interval from 1 to 6 months, antibodies are detected in 73% of patients. For a period of 6 months or more, antibodies can be detected in 42% of patients.

Conclusion. The optimal time for detecting antibodies from the disease onset is 4-6 weeks. Antibodies after antibiotic therapy can persist for a long time, in a third of patients up to 6 months or more.
At the Turn: Flint Mining as an Element of Social Changes in the Second Half of the Fifth Millennium BC in Western Lesser Poland
Authors: Trela-Kieferling Elżbieta , Stefański Damian
Published: November 2022

In the second half of the fifth millennium BC, a new model of supply and processing of siliceous rocks appeared in western Lesser Poland (Małopolska). The existing methods of production of blades and flakes from small cores obtained at a short distance from the settlement were supplemented by those enabling the production of much longer blades from cores made from raw material obtained by mining. The significant increase in the size of lithics meant that this moment was referred to as “the metric change” (Polish: przełom metryczny). It was assumed that this was due to internal technological development within the early Neolithic communities of the Lengyel-Polgár cycle. This paper introduces a different explanation for this phenomenon. It is argued that the new model of supply appeared as an already developed model that was implemented by experienced outsiders. A thesis that the indicated technological caesura is not categorical and new patterns in a relatively small area could co-exist with previous ones.
Re-working the Past: Evidence for Late Neolithic and Early Bronze Age Flint Extraction at the Early Neolithic Mines of Sussex
Authors: Baczkowski Jon
Published: November 2022

This paper will summarise evidence for Late Neolithic and Early Bronze Age flint extraction at the Southern English mines, beginning with a brief synopsis of their chronology and followed by a summary of mine lithics. It is argued that understanding later mining is equally important as examining its beginning, because the Neolithic is framed by the pursuit of flint from deep mines with significant episodes of extraction at its beginning and end. A focus is maintained on the flint mines located in the county of Sussex because these are the best researched of the English mines. This research represents a limited study of the Late Neolithic/Early Bronze Age activity at the Early Neolithic mines, because it is far from exhaustive. Nonetheless, this paper will attempt to define the Late Neolithic and Bronze Age flint working activity at the mines and will question if this activity is associated with new episodes of shaft-mining or informal methods of extraction, such as quarrying or surface collection of earlier mine waste.
Krzemionki in the Literature Published in the Years 1923–1939
Authors: Malak Magdalena
Published: November 2022

This article presents the literature referring to the striped flint mine in Krzemionki Opatowskie published within the first few years after the discovery of the site until 1939. The exceptional significance of the mine in Krzemionki inspired many scholars and authors of both scientific as well as popular-scientific texts. Information about this prehistoric mine also appeared in articles related to disciplines of science other than archaeology, as well as in the general press and a sightseeing guide.
Prehistoric Stone Raw Materials from the Bükk Mountains in Northeastern Hungary
Authors: Faragó Norbert , Péter Réka Katalin Péter , Viktorik Orsolya , Máté László , Mester Zsolt
Published: November 2022

From the period of the Neanderthals to those of the Late Neolithic populations, the Bükk Mountains region played an important part in the lives of various prehistoric societies, and the varied geological history of this territory provided distinct circumstances for the production of stone implements. The major goal of our research is to outline the current state of information concerning the prehistoric use of the diverse silicified source materials of the Bükk mountains. The results of these studies are presented concerning four selected local rock types, cited in the archaeological literature as the silicified sandstone of Egerbakta, the radiolarite and hornstone (black chert), the silicified marlstone and the quartz-porphyry (metarhyolite). Except for the latter, little attention has previously been paid to studying them in detail. Our new petrographic analyses revealed two variants of the raw material from Egerbakta: a silicified sandstone and a diatomaceous detrital chert. The other samples turned out to be radiolarites. This result confirmed what was already suggested for the hornstones (black cherts), however, it has new consequences for the “silicified marlstone”. Regarding the prehistoric use of the selected raw materials, archaeological data show interesting dynamics through time. The Mousterian groups of the region used a large spectrum of rocks for lithic tools with a preference for hornstone (black cherts) and radiolarite in the southern part, and the quartz-porphyry (metarhyolite) in the northeastern part. The Bábonyian/Micoquian assemblages are characterized by a bifacial toolkit and an apparent preference for quartz-porphyry (metarhyolite). At the beginning of the Upper Palaeolithic, a new attitude appears in the region: the Aurignacian groups almost completely ignored local sources. During the Neolithization of the Carpathian Basin, the lithic assemblages of the Alföld Linear Pottery culture became more and more habituated to the locally available rock types, albeit their raw material economy was based on limnosilicites and obsidian. Another change took place during the Late Neolithic when supra-regional sources became dominant over local or regional sources.
PENGARUH PROFITABILITAS, LEVERAGE, DAN UKURAN PERUSAHAAN TERHADAP NILAI PERUSAHAAN (Studi Kasus Pada Perusahaan Food And Beverage Yang Terdaftar Di Bursa Efek Indonesia)
Authors: Kusumaningrum Diyah Putri , Iswara Ulfah Setia
Published: November 2022

Penelitian ini dilakukan bertujuan untuk menguji dan menganalisis variabel independen dan variabel dependen, yaitu variabel independen meliputi pengaruh profitabilitas, leverage, dan ukuran perusahaan terhadap nilai perusahan. Profitabilitas yang diukur dengan Return On Assets (ROA), leverage yang diukur dengan Debt To Equity Ratio (DER), dan ukuran perusahaan yang diukur dengan SIZE, selanjutnya variabel dependen yaitu nilai perusahaan diukur dengan Price Book Value (PBV). Sampel yang digunakan pada penelitian ini adalah perusahaan food and beverage yang terdaftar di Bursa Efek Indonesia (BEI) pada tahun 2017-2021. Jenis penelitian ini adalah penelitian kuantitatif. Teknik pengambilan sampel adalah purposive sampling. Berdasarkan kriteria-kriteria yang diperoleh dari sampel penelitian sebanyak 14 perusahaan sebagai sampel perusahaan dan diperoleh 70 data sebagai data observasi. Metode analisis yang dipergunakan dalam penelitian ini yaitu analisis linier berganda. Hasil penelitian menunjukan bahwa: (a)  profitabilitas berpengaruh positif terhadap nilai perusahaan, artinya profitabilitas dalam perusahaan menjadi prospek yang baik untuk investor dimasa depan, (b) leverage berpengaruh positif terhadap nilai perusahaan, artinya leverage yang tinggi  akan meningkatkan nilai perusahaan yang akan disukai oleh investor,  dan (c) ukuran perusahaan tidak berpengaruh terhadap nilai perusahaan, artinya besar kecilnya perusahaan tidak bisa menjadi patokan profit dalam sebuah perusahaan.
Development of learning media for understanding procedure text based on powtoon application for class VII students of SMP Srijaya Negara
Authors: Sucini Emelia , Nurhayati Nurhayati , Izzah Izzah
Published: November 2022

The reasons for using learning media are important in learning, namely improving the quality of learning, the demands of a new paradigm, market needs, and the vision of global education. This study aims to describe the results of the analysis of the needs of seventh grade students and teachers of SMP Srijaya Negara Palembang for the instructional media for understanding the powtoon application-based procedural text, describe the design of understanding the powtoon application-based procedural text, and describe the results of the validation. expert on powtoon application-based learning media. This study uses a research method that refers to the modified Alessi & Trollip research and development model, namely (1) the planning stage, (2) the design stage, and (3) the development stage. The instructional media for understanding the text of this procedure was developed based on the results of the analysis of the needs of students and teachers. The results show that the overall learning media for understanding procedure text based on the powtoon applicationis declared valid.
The Effect of Project Bases Learning Model With Learning Colaborative Toward Student’s Achievement
Authors: Suyanti Retno Dwi , Br Karo Desnapia Nesrani , Sitompul Nopita
Published: November 2022

This research has the purpose to know the student’s achievement in Acid-Base topic by implementing Project Based Learning model. The population of this research are all Senior High School students grade XI in Berastagi , which the samples are 2 classes XIth grade chosen by purposive sampling. 1st as experiment class was taught by Project Based Learning Model while 2nd class as control class was taught by Conventional model. The instrument test had been standardized by expert validator and empiric validity process. The result of test standardization is 20 multiple choice questions with reliability 0.865 . The research resulted that the data is normal distributed and samples are homogenous. The result data showed that student’s achievement taught by Project based learning with lesson study gave higher significance different compared with student’s achievement taught by conventional model. The statement supported by the result of hypothesis testing is t count (5.78) > t table (1.67).