bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficiency of modified central composite designs with fractional factorial replicates for five-variable nonstandard models
Authors: Iwundu M.P. , Nwoshopo D.E.
Published: June 2022

The efficiencies of standard central composite designs are compared with modified central composite designs on non-standard models using D- and G-efficiency criteria. Diagonal elements of the Hat matrix are utilized in the construction of the modified central composite designs. Fractional factorial replicates are used to maintain manageable design sizes. Results show that D-efficiencies of the designs decline for standard CCDs as the number of missing quadratic terms increases but increase with modified CCDs for increased number of missing quadratic terms. Similarly, G-efficiencies of the designs decline for standard CCDs as the number of missing quadratic terms increases but increase with modified CCDs for increased number of missing quadratic terms.
Quantile crossing as it pertains to sample size and goodness of fit: A simulation study
Authors: Nwakuya M.T. , Masha M.I.
Published: June 2022

Estimation of quantile regression curves individually causes quantile crossing, which eventually leads to an invalid estimation of the predictor effect. This work implemented quantile regression coefficient modeling (QRCM) where the regression coefficients are modeled as parametric functions of the order of the quantile in other to eliminate crossing. Four different samples of sizes 30, 50, 100 and 500 were simulated in other to investigate the effect of sample size on crossing and also to investigate the effect of crossing on model fit. The results show that as the sample sizes were increased crossing was reduced, but with a very large sample size crossing was not observed at all. The results also revealed that the presence of crossing caused the models not to be well specified but with the elimination of crossing the models were seen to be well specified.
Investigation of Hibiscus sabdariffa as a new eco-friendly photo-larvicidal natural product for the control of mosquitoes
Authors: Ugboaja T.A. , Ndukwe G.I. , Fekerurhobo G.K.
Published: June 2022

The Culex spp. is a vector of several disease-causing organisms including filarial parasites, encephalitis virus and the West Nile Virus; the control of these diseases is hinged on controlling the vector. Synthetic insecticides have previously been applied in the control of Culex spp. which poses a danger to the environment. In the present research, the use of light and a naturally occurring product, methanol extract of Hibiscus sabdariffa calyces (HSME), in controlling the breeding and spread of Culex tritaeniorhynochus was investigated. Third instar larvae of C. tritaeniorhynochus were fed with HSME and exposed to light for 18 hours. Results indicate over 80% mortality of the test sample with LC50 of 528.44 ppm; also increase in percentage mortality with corresponding increase in HSME concentration and longer irradiation time was established. The trend observed in light reactions was not seen in the control and dark reactions, implying that the presence of light and the photosensitizer (HSME) is required to induce mortality in Culex tritaeniorhynochus larvae population.
Terrestrial molluscs species richness and diversity in Gashaka - Gumti National Park, Taraba State, Nigeria.
Authors: Ororode I.O.
Published: June 2022

To assess the biodiversity of terrestrial molluscs in Gashaka-Gumti National Park, a four plot (20 x 20m) each within the park were sampled by searching the forest floor, tree trunk, fallen logs, root facies, and vegetation for the presence of mollusks. The species found were collected by hand picking.A total of 819 specimens comprising 22 species belonging to six molluscan families were collected from four plots. Each plot yielded between 8 to14 species (Mean:10, Standard Deviation:2.71) and 33 to 683 individuals (Mean:204.75, Standard Deviation :319.09). The most abundant species in the park was Curvella sp. represented by 683 individuals (79.4%) of the total sampled species. The most abundant family is Streptaxidae represented by 8 species (36.4%) of the total sample.The sample intensity was 37.22 while the Inventory Completeness is 79.31%. Eleven (11) species occurred as singleton across plots while ten (10) species occurred as doubleton across the four plots sampled.The Whittaker Index is 4.00. The rarefaction curve nearly reached an asymptote as sampling stopped. The nonparametric estimator Chao 2 and jackknife 2 were 28.05 and 33.99 of all sample collected. The dendogram of similarity by plots using Bray-Curtis similarity of index show the close relationship of two plots in terms of species. It shows that there is no significant difference between plots. Plot 1 and 4(P=0.4329), Plot 2 and 3 (P=0.9595), Plot 1 and 3 (P=0.2390), Plot 2 and 4 (P= 0.78). In conclusion, the family Subulinidae has the most abundant individuals with 733 individuals representing 89.4% while Streptaxidae occur as the most abundant family with 8 species of the total sample.
MicroRNA-595 promotes osteogenic differentiation of bone marrow mesenchymal stem cells by targeting HMGA2
Authors: Gao Bingjun , Wu Yarong , Zhou Lijian , Chen Xin
Published: June 2022

Purpose: To investigate the effect of miR-595 on osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).Methods: Human BMSCs were osteogenically differentiated, and protein expression of alkaline phosphatase (ALP), osteocalcin (OCN), and Runt-related transcription factor 2 (RUNX2) were evaluated by western blot. Expression of miR-595 was measured by quantitative reverse transcription (qRT-PCR). The effect of miR-595 on viability of BMSCs was determined by MTT assay. Osteogenic differentiation of BMSCs was assessed by ALP and Alizarin red S (ARS) staining. The target gene of miR-595 was predicted by TargetScan analysis and validated by luciferase activity assay.Results: MiR-595 expression was higher in osteogenically differentiated BMSCs than in undifferentiated BMSCs (p < 0.01). Osteogenic ALP, OCN, and RUNX2 were also upregulated (p < 0.01). MiR-595 expression increased the viability of BMSCs, mineralized bone matrix formation, and ALP activity. High mobility group AT-hook 2 (HMGA2) expression was lower in osteogenically differentiated BMSCs and was found to be a target of miR-595. Overexpression of HMGA2 attenuated the miR-595-induced increase in cell viability, ALP activity, mineralized bone matrix formation, and osteogenic gene expression in BMSCs.Conclusion: The miR-595/HMGA2 axis is involved in osteogenic differentiation of BMSCs suggesting that it is a promising therapeutic target for osteoporosis.
Verteporfin mitigates sepsis-induced liver injury by blocking macrophage-derived inflammation
Authors: Yang Yaopeng , Wang Anxiu , Zhang Su , Peng Guangming , Wu Haiying
Published: June 2022

Purpose: To study the role of yes-associated protein (YAP) inhibition by verteporfin (VTF) in LPSinduced acute liver injury (ALI) after sepsis.Methods: In vitro, VTF was used to treat LPS-stimulated RAW 267.4 cells. In vivo, LPS was injected to induce sepsis in mice, followed by treatment with VTF. The inflammatory mediators were determined using quantitative real-time polymerase chain reaction (qRT-PCR), immunofluorescence spectroscopy (IF) and immunohistochemical staining (IHC), and the levels of YAP, P53 and ERK were measured by qRT-PCR, WB and IHC. Moreover, liver histology and liver function were examined using HE staining and ELISA respectively.Results: The results showed that VTF reduced YAP expression and inhibited LPS-induced cell activation and inflammatory cytokine production such as IL-6 and IL-1β, by attenuating the expressions of p53 and ERK pathway in macrophages. The levels of AST, AIL and TBiL remarkably decreased in ALI mice after VTF treatment (p < 0.05). Moreover, it was observed that inflammatory mediators, including inducible nitric oxide synthase (iNOS), IL-6 and IL-1β, decreased significantly in VTF treated mice (P < 0.05).Conclusion: VTF plays an antagonistic role in LPS-induced inflammatory response after ALI. Therefore, VTF is a potential medicinal agent for preventing infectious acute liver injury.
Irbesartan protects against type 2 diabetic nephropathy by regulating miR-93/VEGF and its downstream effectors
Authors: Zhao Fu , Chen Yifei , Yu Fuhai
Published: June 2022

Purpose: To investigate the protective effect of irbesartan against type 2 diabetic nephropathy (T2DN), and the mechanism involved.Methods: Wistar rats (n = 48) were used in this study. Diabetes mellitus (DM) was established in the rats via injection of streptozotocin (STZ). Thereafter, the DM rats were randomly divided into diabetic nephropathy (DN) group and irbesartan group, with 16 rats in each group. Rats in the control group (n = 16) received normal saline in place of irbesartan.Results: Total cholesterol (TC), triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), as well as protein expression levels of VEGF, FN, collagen IV in DN group were significantly higher in irbesartan group than the corresponding levels in normal control group, while miR-93 protein expression level was significantly lower than that in normal control group (p < 0.05). However, the expression level of mir-93 was significantly higher in irbesartan group than in DN group, while levels of TC, TGs, HDL-C, LDL-C and VEGF, as well as protein levels of FN and collagen IV protein were significantly lower than those in DN group (p < 0.05). There was no obvious change in the renal tissues of the normal control group. In contrast, in the DN group, glomerularcapillary loop hypertrophy, narrow glomerular cavity, thick basement membrane, mesangial matrix, and vacuolar degeneration in renal tubular epithelial cells, were evident. Compared with DN group, the pathological changes in the irbesartan group were significantly mitigated (p < 0.05).Conclusion: Irbesartan protects DM rats against type 2 diabetic nephropathy by regulating mir-93/VEGF and its downstream effector molecules. This provides some ideas for the development of new drugs for the prevention of type 2 diabetic nephropathy.
Dexmedetomidine relieves inflammatory response in rats with acute spinal cord injury through IKK/NF-κB signaling pathway
Authors: Zhu Haijuan , Wang Jinbao , Huang Lihua
Published: June 2022

Purpose: To examine the effect of dexmedetomidine (DEX) on inflammatory response in spinal cord damage, and involvement of IKK/NF-κB signaling pathway in the process.Methods: Sixty healthy male Wistar rats were selected and randomly divided into sham, control, IKK inhibition, and DEX groups. Rat hind limb motor function in each group at 1, 24 and 48 h after surgery was determined using Basso Beattie Bresnahan (BBB) method, while Western blot assay was used to evaluate the protein expression levels of IL-1β, IKK and NF-κB in spinal cord tissue.Results: In DEX rat group, neuromotor function at 24 and 48 h, and protein expression level of IL-1β in spinal cord tissue significantly decreased, relative to IKK inhibition group (p < 0.05). There were higher protein expressions of IKK and NF-κB in IKK inhibition and DEX groups than in sham rats, but were lower than the corresponding values for model group (p < 0.05). However, these proteins were significantly downregulated in DEX group, relative to the IKK inhibition rats (p < 0.05).Conclusion: DEX mitigates inflammatory response in rats with acute spinal cord injury via IKK/NF-κB signaling pathway. This provides some ideas for research and development of other drugs for the treatment of acute spinal cord injury.
C1q/tumor necrosis factor (TNF)-associated protein 6 (CTRP6) ameliorates the cognitive dysfunction induced by sevoflurane by activating AMPK/SIRT1 pathway in rats
Authors: Nie Yunming , Wu Yanyue , Huang Xuefen , Chen Zhengzheng , Zhou Yimin
Published: June 2022

Purpose: To evaluate the possible effects of C1q/tumor necrosis factor (TNF)-associated protein 6 (CTRP6) on postoperative cognitive dysfunction (POCD), including the potentially-related signaling pathway.Methods: Behavioral analysis and cognitive impairment were assessed in each group. Immunoblots were used to determine the level of CTRP6 following sevoflurane-induced nerve injury. Hippocampal neurons were identified using Nissl staining, while inflammatory response following neuronal injury was monitored by enzyme-linked immunosorbent assay (ELISA) and quantitative polymerase chain reaction (qPCR). The involvement of adenosine monophosphate-activated protein kinase (AMPK)/sirtuin 1 (SIRT1) pathway was determined using immunoblot.Results: CTRP6 alleviated sevoflurane-induced cognitive dysfunction in rats (p < 0.001). Moreover, CTRP6 reduced sevoflurane-induced nerve injury and inflammation in rats (p < 0.05).Conclusion: CTRP6 ameliorates sevoflurane-induced cognitive dysfunction by activating AMPK/SIRT1 pathway, thus offering a novel target for POCD treatment.
Breviscapine alleviates MPP+-induced damage and apoptosis of SH-SY5Y cells by activating Nrf2 pathway
Authors: Li Dongzhu , Tan Xianpei , Tu Qiang , Xiang Mingqing , Wang Yamei , Yu Ming , Tan Tao
Published: June 2022

Purpose: To investigate the role and mechanism of action of breviscapine (Brp) in 1-methyl-4- phenylpyridinium ion (MPP+)-induced cell injury in human neuroblastoma cell line, SH-SY5Y.Methods: The injury on SH-SY5Y cells was induced using MPP+. Cell viability and apoptotic ability were determined by CCK8 assay and Annexin V/PI staining, respectively. Protein expressions of nuclear factor E2-related factor 2 (Nrf2) and its related downstream proteins - hemeoxygenase 1(HO-1) and NAD(P)H-quinoneoxido reductase 1(NQO1), were determined using Western blotting.Results: Brp dose-dependently attenuated MPP+ induced reduction in the viability of SH SY5Y cells, but alleviated MPP+-induced oxidative stress (OS) and cell injury, as evidenced by the levels of reactive oxygen species (ROS), tyrosine hydroxylase (TH), lactic dehydrogenase (LDH), and dopaminetransporter (DAT) (p < 0.05). Brp decreased the amount of apoptotic cells induced by MPP+, as well as the protein levels of Bax and cleaved-caspase 3, and also induced the activation of Nrf2 signaling pathway (p < 0.05).Conclusion: Brp alleviates MPP+-induced cellular damage and cell apoptosis in SH-SY5Y cells by activating Nrf2 pathway. Thus, Brp is a potential therapeutic candidate for the treatment of PD.
Mechanism of propofol-induced injury in hippocampal neurons in neonatal rats
Authors: Zhang Tao , Wu Jusheng
Published: June 2022

Purpose: To determine the deleterious effect of propofol on hippocampal neurons in developing rats, and the underlying mechanism.Methods: Sixty Wistar rats were randomly assigned to fat emulsion group, low-dose propofol group and high-dose propofol group. Immunohistochemical staining of brain samples was used to detect BrdUpositive (+), nestin+ and GFAP+ cells. The influence of propofol on cellular multiplication, number of neurons in dentate gyrus, activation of astrocytes and microglial activation were determined. The expression levels of Sox2, Akt and ERK signal pathway-associated proteins were assayed by Western blotting.Results: The population of BrdU-positive cells was significantly lower in propofol-exposed rats than in fat emulsion rats, while the levels of Sox2 protein were markedly and dose-dependably lower in propofol-exposed rats than the corresponding levels in fat emulsion rats (p < 0.05). The numbers of nestin+ cells, GFAP+ cells and Iba1+ cells in propofol-exposed rats were significantly and concentration-dependently reduced, relative to the corresponding numbers in fat emulsion rats, while p-Akt and p-ERK1/2 in propofol-exposed rats were and dose-dependently reduced, relative to fat emulsion rats (p < 0.05).Conclusion: Propofol dose-dependently inhibits the proliferation of hippocampal dentate gyrus stem cells, and suppresses the activation of astrocytes and microglia through regulation of the expressions of Akt/ERK signal pathway-associated proteins. This provides a lead for research and development of new drugs for protecting hippocampal neurons.
Development and validation of RP HPLC method for simultaneous determination of picroside I, picroside II, phyllanthin and boeravinone B in a polyherbal hepatoprotective tablet formulation
Authors: Shanbhag Sunil V , Bachute Madhusudan T
Published: June 2022

Purpose: To develop and validate RP-HPLC method for simultaneous determination of four active ingredients: picroside I (PSI), picroside II (PSII), phyllanthin (PHY) and boeravinone-B (BVB) in a polyherbal hepatoprotective tablet formulation.Methods: The study was carried out using Waters X-Bridge, C18 (250 mm x 4.6 mm, 5 μm) column with mobile phase consisting of 5 mM ammonium acetate in 10 % methanol and acetonitrile, with gradient programme at dual wavelengths of 220 nm and 274 nm and flow speed of 1 mL.min-1. The procedure was validated with respect to specificity, linearity, precision, accuracy, system suitability, limit of detection (LOD) and of quantification (LOQ), and robustness in line with ICH specifications.Results: The method was linear within the concentration range of 25 to 200 %, and the values of correlation coefficients (R2) were > 0.999. Intra-day and inter-day RSDs of PAs and RTs were < 5.0 %, with recovery in the range of 100.0 - 106.0 %.Conclusion: The four active ingredients have with good resolution with regard to the method used. The method is rapid, simple, highly selective, sensitive and cost effective, which make it an efficient method for quality assurance.
Clinical efficacy of combination of oxaliplatin and vascular intervention in treatment of advanced cervical cancer and related prognostic factors
Authors: Huang Xinlong , Yan Haiyan , Su Zhenqing , Wang Junsong , Zhang Jianxun , Zhang Xinqin
Published: June 2022

Purpose: To investigate the therapeutic effect of combination of oxaliplatin and vascular intervention in patients with advanced cervical cancer (ACC), and its influence on the prognosis of patients.Methods: One hundred ACC patients were selected and equally assigned to control (oxaliplatin) and combination or study (oxaliplatin plus vascular intervention) groups. The patients in control group received oxaliplatin, while those in study group were treated with oxaliplatin combined with vascular intervention. Clinical efficacy, levels of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor-2 (VEGFR-2), fibroblast growth factor-2 (FGF-2), BFGF and platelet-derived growth factor (PDGF) before and after therapy, and survival rate at 3, 6, 12 and 18 months after therapy were determined compared between the two groups. The prognostic factors were analyzed with logistic factor analysis.Results: The clinical efficacy and survival rate at 3, 6, 12 and 18 months after therapy in the combination group were higher when compared with those of the control group (p < 0.05). After therapy, the levels of VEGF, VEGFR-2, FGF-2, BFGF and PDGF were lower in the combination group than in control group. Age, short-term efficacy and basic diseases were identified as the influencing factors for the prognosis of patients with advanced cervical cancer (p < 0.05).Conclusion: The combination of oxaliplatin and vascular intervention significantly improved clinical treatment efficacy and survival rate in ACC patients. Age, short-term efficacy and basic diseases affected the prognosis of patients.
CK1α protects cardiomyocytes in sepsis-induced myocardial depression by repressing the interaction of ATG5 with myD88/NF-kappaB signaling
Authors: Sun Hongpeng , Wu Yanmei
Published: June 2022

Purpose: To explore the effects of casein kinase 1α (CK1α) on cardiomyocytes in sepsis-induced myocardial depression.Methods: Colorectal ligation puncture (CLP) surgery was performed for the establishment of the mouse model. Total RNAs of the lungs, kidneys, liver tissues and alveolar macrophages were extracted using TRIzol™ reagent, while gene expression analysis was performed by quantitative polymerase chain reaction (qPCR) following reverse transcription. Western blot was employed to evaluate protein expression, and echocardiography was conducted to assess cardiac function. Immunofluorescent assay was performed to determine the expression of p-FOXO3a in primary cardiomyocytes.Results: Inhibition of CK1α impaired autophagy influx, and significantly increased inflammatory cytokines in H9C2 cells after lipopolysaccharide (LPS) treatment (p < 0.05). Moreover, aberrant activation of the Toll-like receptor 4(TLR4)/myD88/NF-kappaB pathway was observed in the H9C2 cell line after LPS treatment (p < 0.05). Immunoprecipitation analysis revealed an interaction between MyD88 and autophagy-related gene 5 (Atg5), and cardiac dysfunction in mice intravenously injectedwith an adenoviral vector containing shRNA (casein kinase 1 α) CSNK1A1 was suppressed (p < 0.05). In contrast, overexpression of CK1α remarkably improved cardiac systolic function (p < 0.05), the expression of inflammatory cytokines was repressed, and autophagy was enhanced in the hearts of mice with the specific overexpression of CSNK1A1 in cardiomyocytes (p < 0.05). In Atg5-deficient mice pretreated with DC661, the protective effect of adenoviral vector containing CK1α overexpression was eliminated.Conclusion: CK1α protects cardiomyocytes during sepsis after the inhibition of TLR/MyD88/NF-kappaBpathway via interaction of Atg5 with MyD88. The results of the current study may provide new insights into the treatment of sepsis-induced myocardial depression.
Mô hình lớp học đảo ngược của phương pháp Blended Learning và gợi ý phương pháp dạy học tất yếu trong chuyển đổi số của giáo dục đại học hiện nay
Authors: Hoà Trần Thị Bích
Published: June 2022

Trước yêu cầu thực hiện nhiệm vụ chuyển đổi số của giáo dục đại học Việt Nam thì cần thiết phải vận dụng một phương pháp dạy học tối ưu nhất để vừa nâng cao chất lượng giáo dục vừa thực hiện thành công sứ mệnh tiên phong này. Phương pháp Blended Learning được nhiều nước trên thế giới triển khai và đạt được hiệu quả cao. Tuy nhiên, ở nước ta khi dịch Covid-19 bùng phát, mô hình này mới được áp dụng nhưng vẫn còn rất rời rạc và chưa hoàn thiện. Thông qua thực tiễn giảng dạy và tham khảo các nghiên cứu về dạy học trực tuyến, bài báo khẳng định lợi ích của việc áp dụng phương pháp Blended Learning, cụ thể là mô hình lớp học đảo ngược, và gợi ý phương pháp dạy học tất yếu ở các trường đại học Việt Nam trong thời kì chuyển đổi số, cũng như cách thức để triển khai thành công mô hình dạy học này.
Xây dựng môi trường học tập chủ động cho sinh viên đại học
Authors: Ngọc Phạm Thái Bảo
Published: June 2022

Phương pháp Học Tập Chủ Động (HTCĐ) đòi hỏi tính tự lực của người học trong quá trình kiến tạo tri thức, áp dụng lý thuyết vào thực tế để giải quyết vấn đề. Tuy đã có nhiều bài viết trong và ngoài nước phân tích các đặc điểm và lợi ích của việc xây dựng môi trường HTCĐ nói chung và phương pháp HTCĐ nói riêng, nhưng tính đến nay vẫn có rất ít bài báo khoa học, đặc biệt là ở Việt Nam, tập trung vào việc xây dựng mô hình môi trường HTCĐ với các tiêu chí đánh giá rõ ràng. Chính vì vậy, bằng phương pháp phân tích theo chủ đề, tác giả bài viết này đã tổng hợp, phân tích, mã hóa và hệ thống hóa kết quả của 57 công trình nghiên cứu trước để thiết lập mô hình môi trường HTCĐ. Trên nền tảng đó, tác giả bài viết đã xây dựng khung đánh giá môi trường học tập theo hướng HTCĐ, và từ đó đề xuất các chiến lược để xây dựng môi trường HTCĐ ở bậc đại học.
Các nhân tố ảnh hưởng đến chất lượng đào tạo trực tuyến tại các trường đại học trong bối cảnh COVID-19: Nghiên cứu tại thành phố Đà Nẵng
Authors: Phượng Lê Thái
Published: June 2022

Đại dịch COVID-19 đã tạo áp lực đối với ngành giáo dục nhưng qua đó cũng tạo cơ hội và động lực để ngành giáo dục tiếp cận với xu hướng chuyển đổi số. Các trường đại học hiện nay đều chọn phương pháp học trực tuyến để đảm bảo an toàn và tính chủ động trong bối cảnh hiện tại. Nghiên cứu này nhằm xác định các nhân tố ảnh hưởng đến chất lượng học trực tuyến trong bối cảnh COVID-19. Kết quả phân tích hồi quy tuyến tính từ cuộc khảo sát 424 sinh viên của một số trường Đại học trên địa bàn thành phố Đà Nẵng cho thấy 6 nhân tố tác động đến chất lượng học trực tuyến trong bối cảnh COVID-19 gồm: (1) Thiết kế giảng dạy; (2) Nội dung giảng dạy; (3) Đặc điểm giảng viên; (4) Đặc điểm sinh viên; (5) Hỗ trợ công nghệ; (6) Điều kiện học tập. Nghiên cứu cũng đưa ra một số gợi ý đối với giảng viên, sinh viên và nhà trường nhằm nâng cao chất lượng dạy và học trực tuyến.

ABSTRACT

The COVID-19 pandemic has put pressure on the education industry, but it also creates opportunities and impetus for the education industry to approach the trend of digital transformation. Currently, universities are choosing online learning methods to ensure safety and initiative in the current context. This study aims to determine the factors affecting the quality of E-Learning during COVID – 19 pandemic. The regression analysis results from a survey of 424 students at several universities in the city of Danang showed that 6 factors included: (1) Course design; (2) Course content; (3) Lecturer characteristics; (4) Student characteristics; (5) Technolgy support; (6) learning conditions. The analysis results will suggest some orientations for lecturer, student and university to enhance the quality of E-Learning.
Ảnh hưởng của tư duy phản biện và kỹ năng giải quyết vấn đề đến kết quả học tập của sinh viên khoa kinh tế - Trường Đại học Cần Thơ
Authors: Trân Ngô Mỹ , Anh Võ Thị Huỳnh
Published: June 2022

Mục tiêu của nghiên cứu này là phân tích sự ảnh hưởng của tư duy phản biện và kỹ năng giải quyết vấn đề đến kết quả học tập của sinh viên dựa trên số liệu sơ cấp thu thập từ 291 sinh viên Khoa Kinh tế - Trường Đại học Cần Thơ. Kết quả phân tích hồi quy OLS cung cấp bằng chứng thống kê cho thấy 03 nhóm nhân tố đo lường khả năng tư duy phản biện (gồm sự nhiệt huyết, trưởng thành về mặt nhận thức, sự đổi mới) và ba nhóm nhân tố đo lường kỹ năng giải quyết vấn đề (gồm sự tự tin khi giải quyết vấn đề, phong cách tiếp cận - tránh né, khả năng kiềm chế bản thân khi giải quyết vấn đề) có ảnh hưởng tích cực đến kết quả học tập của sinh viên. Kết quả này cho thấy rằng để nâng cao kết quả học tập, sinh viên cần tích cực nâng cao rèn luyện khả năng tư duy phản biện và cải thiện kỹ năng giải quyết vấn đề của bản thân. Để có thể giải quyết tốt các vấn đề phát sinh, sinh viên nên có cái nhìn tổng quát về một vấn đề từ trong ra ngoài, kèm thêm những thông tin liên quan và cơ sở lý luận chắc chắn. Điều này sẽ giúp sinh viên tự tin hơn để đưa ra những giải pháp hiệu quả hơn.
Сalculation of chemical reaction temperatures of stepwise iron reduction from hematite with СО gas and gasification of solid carbon by degrees of chemical affinities of substances with oxygen
Authors: Panteikov Sergei
Published: June 2022

This article presents the results of a theoretical analysis that made it possible to evaluate the thermodynamic conditions for the flow of chemical reactions of the stepwise reduction of iron from hematite with a reducing gas CO and the Bell–Boudoir chemical reaction (gasification of solid carbon). Taking into account the degrees of chemical affinity for oxygen of the reduced substance and the reducing agent, it is confirmed that for each of the indicated reduction reactions, there is a certain (called the “boundary” temperature by the author), up to (for the processes of reduction of magnetite from hematite and wustite from magnetite) or above (for the process of reducing iron from wuestite) which the reducing gas CO can not thermodynamically be a reducing agent for iron or its lower oxides, and also up to which the gasification of solid carbon by the Bell–Boudoir reaction is thermodynamically impossible. Using the expressions available in the literature and derived by the author of the work, graphical dependences of the numerical values of the Gibbs free energy on temperature were obtained for oxidative reactions of obtaining (due to oxidation with gaseous oxygen) iron oxides (FeO from Fe, Fe3O4 from FeO, Fe2O3 from Fe3O4 and carbon oxides (CO from C, СО2 from C and from CO), which made it possible to estimate the degree of chemical affinity of the reduced substance and the reducing agent for oxygen in these oxidative reactions; based on which all possible numerical values of the boundary temperatures and the temperature range of their thermodynamically possible occurrence were found for the reduction reactions of the stepwise production of iron from hematite with CO gas and gasification of solid carbon, the most probable of them were substantiated.
Eastern European Experience in the Application of Multilayer Reinforced Concrete Elements of External Wall Fencing
Authors: Krus Yurii
Published: June 2022

The capital building field is constantly updating the tasks: to reduce material consumption, cost and complexity of building, the mass of buildings and structures; significantly improve thermal protection; to increase the level of industrialization of building and factory readiness of prefabricated constructions; to improve the architectural and operational qualities of buildings and structures. Practical realization of the set tasks entails the the necessity to expand the use effective kinds of building materials and constructions, improving their properties. The field of effective three-layer constructions in civil, industrial and agricultural building is wide and multifaceted, as it covers almost all constructive elements of buildings, the solution of which depends on the functional requirements imposed on buildings and structures, local climatic and geological conditions, availability of building materials, level of development industrial base, etc. Already behind the idea itself of layered reinforced concrete constructiones have significant advantages: 1) the ability to select the materials of the layers taking into account the effective use of their main functional qualities; 2) reducing the cost and outlay of cement; 3) weight reduction of separate constructions and buildings and/or structures as a whole; 4) reducing heat consumption and increasing heat transfer resistance without thickening the construction; 5) improving the temperature-humidity regime in the room, etc. The purpose of this article is to perform a brief overview of research, proposals for standardization of design developments conducted during the most active implementation in Eastern European building practice of three-layer reinforced concrete constructions for fencing by the heat, air and waterproofing properties, strength, deformations and crack resistance, as well as their manufacturing technology. The article takes into account the results of research, field observations, materials for the development of new proposals, accumulated in many research and design departments of Eastern Europe in the period from the late 60’s to mid-80’s of the 20th century (Research Institute of Building Constructions, Kyiv Zonal Research Institute of Experimental Design, Ukrainian Research and Design Institute of Civil Rural Construction (Ukraine); Central Research Institute of Building Constructions named after V.A. Kucherenko, All-Union Research Institute of Fire Safety, All-Union Scientific Research Institute of Reinforced Concrete, Central Research and Design Institute of Residential and Public Buildings, Central Research and Design and Experimental Institute of Industrial Buildings and Structures, Central Research Institute of Experimental Design of Commercial and Domestic Buildings and Tourist Complexes (Russia), etc.).
Train Driver Fatigue Detection Using Eye Feature Vector and Support Vector Machine
Authors: Li Taiguo , Zhang Tiance ,, , Li Quanqin
Published: June 2022

Fatigue driving is one of the main causes of traffic accidents. The eye features are the important cues of fatigue detection. In order to improve the accuracy and robustness of detection based on a single eye feature, we propose a fatigue detection algorithm based on the eye feature (EFV) vector. Firstly, the coordinates of the eye region were localized with facial landmarks detector and the landmarks geometric relation (LGR) was calculated as a feature value. Secondly, a deep transfer learning network was designed to classify the driver eye state on a small dataset. The probability value of the eyes being open state was calculated. Then an eye feature vector was constructed to overcome the limitations of a single fixed threshold and a support vector machine (SVM) model was trained for eye state classification recognition. Finally, the performance of the proposed detection model was evaluated by the percentage of eyelid closure over time (PERCLOS) criterion. The results show that the accuracy of this model can reach 91.67% on the test database, which is higher than the single-feature-based method. This work lays a foundation for the online fatigue detection of train drivers and the deployment of the train driving monitoring system.
Impact of evidence-based pharmacotherapy (EBP) elective course on fourth year students’ performance
Authors: Pinner Nathan A. , Starr Jessica A. , Lisenby Katelin M.
Published: June 2022

Introduction: Evidenced-based clinical reasoning and literature evaluation skills are essential aspects of pharmacy education and a variety of methods to incorporate these skills into the pharmacy curriculum exist. The authors sought to determine whether an evidence-based pharmacotherapy (EBP) elective course that focused on journal club presentations improved performance during Advanced Pharmacy Practice Experiences (APPEs). 
Methods: Students enrolled in the EBP course were compared to peers not enrolled in the course during the 2009-2011 academic years. Student performance in patient care, clinical reasoning, and literature evaluation domains was assessed. These domains included scores on APPEs, pharmaceutical care ability profile (PCAP), journal clubs, patient presentations, and seminars.    
Results: This analysis included 368 APPEs completed by EBP students and 2922 APPEs completed by non-EBP students. Mean scores on APPEs were 90.36% and 89.75% for the EBP and non-EBP groups (p=0.218). Performance on other measures of clinical reasoning and literature evaluation were also comparable.   
Conclusion: The analysis of this study found that enrollment in an elective course focused on intensive literature evaluation, presentations, and clinical application did not result in measurable differences in existing performance metrics during APPEs.
Pembelajaran Jarak Jauh Semasa Pandemik Covid-19: Implikasinya Terhadap Kesihatan Mental Pelajar UTHM Pagoh
Authors: Kirin Arwansyah Bin , Borham Abd Shakor Bin , Marpuah Siti , Mardhiah Wan Ainaa
Published: June 2022

The coronavirus outbreak (Covid-19) which has been declared a pandemic by the World Health Organization (WHO) has had a huge impact on the world community today. The pandemic situation has brought humanity to a new challenge in maintaining spiritual and mental strength. The feelings of anxiety, fear, stress, depression and worry that afflict Malaysians have disrupted aspects of psychology and personal well-being which are important elements in human life. The study found, concerns about mental health issues among children, teenagers and adults were seen to be increasing compared to the previous year. This contributes to reported cases including suicidal ideation, anxiety, depression and stress. Changes in living norms had a negative impact on mental health especially among students. They easily feel anxious and depressed with the state of Covid-19 and the volatile new regulations including changes in the education system using Distance Learning (DL) methods. DL is seen to have a negative impact on the mental health of students. In order to form a healthy and perfect individual, the physical and mental needs of students need to be met. Thus, a study on the effects of DL on mental health during pandemic era was conducted on students of Universiti Tun Hussein Onn Malaysia (UTHM), Pagoh, Johor. In achieving the objectives, the study was conducted with the method of data collection by questionnaire and strengthen the information through literature and library materials. The results of the study found that the impact of DL on students' mental health is at a high level. This suggests that the mental health problems of the students were disrupted during the Covid-19 pandemic. Therefore, the implications of this study are expected to contribute to society and government in overcoming the mental health of students when facing challenges such as the Covid-19 pandemic and others.
Criminal Responsibility for The Crime of Torture under Investigation According to The Federal Penal Code of The United Arab Emirates
Authors: Alhajjaji Hajaj Naji Nasr
Published: June 2022

Despite the civilized human and legal progress that humanity is witnessing, the acts of torture committed by public officials against the accused in order to get them to confess to the crimes they are suspected of committing are still continuing, and this is a clear violation of all international and national norms and laws that criminalize these acts, as this research aims To clarify the legal framework for the crime of torturing the accused to drive a confession in accordance with the Federal Penal Code of the United Arab Emirates, and to distinguish between this crime and other crimes with similar acts, by answering the following study questions: What is the concept of the crime of torture? And what are its pillars? And the components of this crime? How can this crime be distinguished from other similar crimes? , where the descriptive analytical method was followed in this study, and at the end of this study several results were reached, the most important of which are: the hypnosis, the lie detector, the prolonged interrogation, the interrogation under the influence of anesthesia (the truth drug), put pressure on the freedom of the accused to defend himself And that the legislator in the UAE has referred the result of the infringing intent represented in the death of the victim to the crime of manslaughter, based on the text of the first paragraph of Article No. 387 of the Federal Penal Code.
The Challenges Facing The Palestinian Medical Staff in Light of The Zionist Attacks: An Analytical Legal Study
Authors: Oun Mohammed Awni Abu
Published: June 2022

The Palestinian medical crews exert great efforts in serving the Palestinians in their path of struggle against the Israeli occupation's criminality and arbitrariness. For so long, they have been subjected to several Israeli attacks that costed them a large number of martyrs and causalities as well as huge damages to medical institutes and constructions. Basically, this study determines three main claims; the Protection of Medical Crews according to the International Law, the Prominent Stations that Highlighted the Role of Medical Crews in the Palestinians' Path of Struggle, and Sorts, Shapes and Statistics of Israeli Violations against the Palestinian Medical Crews. The researcher used the descriptive analysis approach. Moreover, the study came up with several results. Most importantly, confirming the importance of the position of the Palestinian medical crews and considering them as a vital part of the Palestinian national work and emphasizing that the Israeli occupation committed diverse arbitrary violations against those crews with impunity. Finally, it recommends that the medical crews must be supported so they can keep serving the Palestinians, the Israeli crimes against the medical crews must be exposed, and an Islamic body representing an organizational baseline at the level of the Islamic nations must be built in order to legally prosecute and hold the Israeli occupation accountable before the international courts.
Inheritance of Adopted Child in Muslim Intestate Succession Law of Sri Lanka: An Analytical Juristic Study
Authors: Jiffry Mohammed Arafath Careem Mohammed , Zaroum Abdul Hamid Mohamed Ali , Awang Abdul Bari
Published: June 2022

The main focus of this study is to examine the law of Inheritance as applied to the Muslim community in Sri Lanka where the community constitutes the second largest minority of the total population of the country, through systemized research conducted in the area of Fiqh and on the relevant existing law of the nation. Thus, the research mainly involves the inconsistencies or differences between two distinct legal regimes, i.e., Islamic jurisprudence and the state's statutory law in the field specified above. The research has revealed that matters related to the Inheritance of Muslims will be dealt with in accordance with the Islamic jurisprudence, while common law is applied when testacy matters are involved. It has been established by the supreme court of Sri Lanka that a child adopted by Muslim parents would not be entitled to become their heir as the matter is governed by the Act legislated in compliance with the principles of the Islamic jurisprudence. This paper contains two matters; firstly, it deals with a historical background of the Muslim intestate succussion ordinance in Sri Lanka, and later exclusively examines the law which is applicable for Sri Lankan Muslims in terms of the adopted child inheritance in light of Islamic jurisprudence. Induction and textual analysis have been employed in this work in order to scrutinize the law relating to intestate succession and Islamic jurisprudence. This investigation concludes with three remarkable points as follows: First, Sri Lankan Muslim minority community has a right to apply Islamic law in terms of intestate succussion as per section no10, 1931. Next, in spite of the adoption ordinance being applicable to all Sri Lankans, which permits inheritance rights to an adopted child, is not applicable to the Muslims according to the Supreme Court, referring to Muslim intestate succession law which does not allow inheritance rights to an adopted child. Last, the existing Muslim intestate succession law requires some details that provide clear ideas regarding the law to avoid misinterpretation and needs to be reformed.
Keistimewaan Bahasa Arab Sebagai bahasa al-Quran dan Kepentingan Menguasainya Bagi Para Mufassirīn
Authors: Osman Rahmah Binti Ahmad H. , Hassan Muhammad Ikram Abu
Published: June 2022

A Mufassir is like a jewel for Muslims. His task is very important in providing a true understanding of the verses of the Qur'an which is the word of Allah SWT. Since the Qur’an was revealed in Arabic and understanding its contents is necessary to tadabbur and observation, then this study examines one of the most important aspects that need to be mastered by a mufassir which is to know and understand the Arabic language. The purpose of this study is to dismantle the importance of the elements of the Arabic language for a mufassir, further examine the great impact of the Arabic language in understanding the Qur'an. Similarly, identify the basic knowledge in the branch of Arabic language that needs to be mastered by a commentator. This study uses a descriptive method by collecting the views of scholars of tafsir and the Arabic language of the past on the importance of mastering and understanding the Arabic language and then study and draw conclusions from it. The study found that understanding the Qur’an is one of the most important requirements in Islamic law and cannot achieve understanding of the Qur’an except by mastering the Arabic language. In addition, in understanding the Qur’an there are some important sciences that are listed largely under the branch of Arabic language. In addition, the law of learning the Arabic language is Fardhu Kifayah for Muslims.
Programa de Profesionalización de la UNAE y los desafíos a considerar en la formación de educadores
Authors: Pinos Karina Maribel Castillo , Loja Carolina Mercedes Loja , Suco Luis Miguel Quito
Published: June 2022

Los programas de profesionalización docente están encaminados a formar profesionales en el campo pedagógico ampliamente capacitados para responder a las necesidades educativas de las comunidades en las que se encuentran. En su mayoría, la centralidad de estos programas formativos radica en promover la mejora de los conocimientos y las competencias de docentes que ejercen esta actividad pero que no cuentan con un título profesional, sin embargo, a menudo no se toman en cuenta las realidades sociales en las que se desenvuelven y los desafíos a los que se enfrentan. Por lo tanto, a través del presente estudio se buscó analizar los desafíos a considerar en la formación de educadores de la provincia de Morona Santiago en el Programa de Profesionalización de la UNAE, particularmente en relación a las competencias que poseen respecto al uso de herramientas tecnológicas.
Three Horizons Meets Presencing for Inclusive, Just and Equitable Futures
Authors: Koenig Oliver , Seneque Megan , Sharpe Bill , Ash-Harper Zahra , Bergheim Stefan , Hodgson Anthony , Odugleh-Kolev Asiya
Published: June 2022

The In Dialogue piece in this issue, brings together Oliver Koenig, Megan Seneque, Bill Sharpe, Zahra Ash-Harper, Stefan Bergheim, Anthony Hodgson, and Asiya Odugleh-Kolev to explore the links between Presencing and Three Horizons in the context of creating inclusive, just and equitable futures. The conversants explore what it means to avoid totalising structures (however well intended), as we work with a plurality of perspectives in the kind of reflexive futuring processes that are contained in both the Three Horizons and in Presencing. This exploration around the nature and quality of structure required for authentic presence and for the emergence of collective insight from a plurality of perspectives, drew the conversants to the nature of structuring that love brings.
Anais VI Congresso Científico Internacional IMEPAC
Authors: Ensino, Pesquisa e Extensão Revista Master
Published: June 2022

O Congresso Científico Internacional IMEPAC tem como objetivo fomentar a iniciação científica, a publicação e divulgação de trabalhos, bem como, promover a reflexão, discussão e ações relacionados a uma nova temática a cada ano.

Em sua sexta edição, em 2021 o foco estará em uma área de suma importância para o futuro de qualquer negócio no momento: O futuro das profissões no pós-pandemia.

            A necessidade do isolamento social para conter a propagação do Coronavírus acelerou as transformações sobre o mercado de trabalho e negócios. Algumas mudanças já estão claras nas relações corporativas, como o aumento das atividades em home office, mas como será o mercado de trabalho pós-pandemia?

Essa será a primeira edição internacional e 100% virtual, contando com 2 abordagens:

• Eixo Temático 1: Ciência, Relações Humanas e Sustentabilidade (social, econômica e ambiental)

• Eixo Temático 2: Tecnologia e inovação à luz da Ciência
Challenges to Mental Health Security and Safety of Older Adults in the U.S.
Authors: Ellen L. Csikai
Published: June 2022

Although rates of Covid-19 infection are lower for older adults, the mortality rates are higher than all other ages. While the health challenges are evident, the mental health effects of the pandemic are less evident. The term “compassionate ageism” has been used to describe protection of all older adults as vulnerable groups, however it overlooks individual factors that may mitigate risk and enhance mental health aspects of coping with the realities of the pandemic. Isolation and separation from families and once enjoyed activities, whether residing in their own homes or long-term care facilities, has taken an immeasurable physical and mental health toll on older adults. Safety and security for mental health as well as physical health must be considered in any strategy to try mitigate the effects on the quality of life of older adults during this critical time in our history.