bluuebunny/crossref_metadata_2025 huggingface dataset:
A pan-cancer analysis of thioredoxin-interacting protein as an immunological and prognostic biomarker
Authors: Guo Xuxue , Huang Mei , Zhang Haonan , Chen Qianhui , Hu Ying , Meng Yan , Wu Changjie , Tu Chenge , Liu Yongfeng , Li Aimin , Li Qingyuan , Zhou Peirong , Liu Side
Published: July 2022

Background

The critical role of thioredoxin-interacting protein (TXNIP) in cellular sulfhydryl redox homeostasis and inflammasome activation is already widely known, however, no pan-cancer analysis is currently available.

Methods

We thus first explored the potential roles ofTXNIPacross thirty-three tumors mainly based on The Cancer Genome Atlas and Gene Expression Omnibus datasets.

Results

TXNIPis lowly expressed in most cancers, and distinct associations exist betweenTXNIPexpression and the prognosis of tumor patients.TXNIPexpression was associated with tumor mutational burden, microsatellite instability, mismatch repair genes, tumor infiltrating immune cell abundance as well as cancer-associated fibroblasts. Moreover, ubiquitin mediated proteolysis, protein post-translational modification and other related pathways were involved in the functional mechanisms ofTXNIP.

Conclusions

Our first pan-cancer study comprehensively revealed the carcinostatic role ofTXNIPacross different tumors. And this molecule may be considered as a potential immunological and prognostic biomarker.
Intermittent theta burst stimulation modulates biceps brachii corticomotor excitability in individuals with tetraplegia
Authors: Mittal Neil , Majdic Blaize C. , Peterson Carrie L.
Published: July 2022

Background

Intermittent theta burst stimulation (iTBS) is a form of repetitive transcranial magnetic stimulation (TMS) that can increase corticomotor excitability of hand muscles in individuals with spinal cord injury (SCI). The objective of this study was to determine the effect of iTBS on the corticomotor excitability of the biceps brachii in individuals with tetraplegia.

Methods

Ten individuals with low cervical SCI (C5-C8) and ten nonimpaired individuals completed three independent sessions. Motor evoked potentials (MEPs) served as our measure of corticomotor excitability and were collected before and after iTBS. MEPs were normalized by the electromyography corresponding to maximum voluntary contraction and analyzed using linear mixed effects models to determine the effect of iTBS (active or sham) on normalized MEPs (nMEPs). iTBS effects were compared to a ratio of active and resting motor thresholds as a measurement of corticomotor conductance potential.

Results

Relative to sham, active iTBS increased nMEPs over time (p < 0.001) in individuals with SCI, but not nonimpaired individuals (p = 0.915). The amplitude of nMEPs were correlated with the biceps corticomotor conductance potential (p < 0.001), with nMEPs decreasing as the ratio increased at different rates after sham or active iTBS.

Conclusions

Preliminary results suggest that iTBS increases biceps corticomotor excitability in individuals with tetraplegia with effects that may be predicted by corticomotor conductance potential.

Clinical trial registration NCT03277521 Registered on clinicaltrials.gov on August 24, 2017
Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers
Authors: Christiansen Colette , Tomlinson Max , Eliot Melissa , Nilsson Emma , Costeira Ricardo , Xia Yujing , Villicaña Sergio , Mompeo Olatz , Wells Philippa , Castillo-Fernandez Juan , Potier Louis , Vohl Marie-Claude , Tchernof Andre , Moustafa Julia El-Sayed , Menni Cristina , Steves Claire J. , Kelsey Karl , Ling Charlotte , Grundberg Elin , Small Kerrin S. , Bell Jordana T.
Published: July 2022

Background

There is considerable evidence for the importance of the DNA methylome in metabolic health, for example, a robust methylation signature has been associated with body mass index (BMI). However, visceral fat (VF) mass accumulation is a greater risk factor for metabolic disease than BMI alone. In this study, we dissect the subcutaneous adipose tissue (SAT) methylome signature relevant to metabolic health by focusing on VF as the major risk factor of metabolic disease. We integrate results with genetic, blood methylation, SAT gene expression, blood metabolomic, dietary intake and metabolic phenotype data to assess and quantify genetic and environmental drivers of the identified signals, as well as their potential functional roles.

Methods

Epigenome-wide association analyses were carried out to determine visceral fat mass-associated differentially methylated positions (VF-DMPs) in SAT samples from 538 TwinsUK participants. Validation and replication were performed in 333 individuals from 3 independent cohorts. To assess functional impacts of the VF-DMPs, the association between VF and gene expression was determined at the genes annotated to the VF-DMPs and an association analysis was carried out to determine whether methylation at the VF-DMPs is associated with gene expression. Further epigenetic analyses were carried out to compare methylation levels at the VF-DMPs as the response variables and a range of different metabolic health phenotypes including android:gynoid fat ratio (AGR), lipids, blood metabolomic profiles, insulin resistance, T2D and dietary intake variables. The results from all analyses were integrated to identify signals that exhibit altered SAT function and have strong relevance to metabolic health.

Results

We identified 1181 CpG positions in 788 genes to be differentially methylated with VF (VF-DMPs) with significant enrichment in the insulin signalling pathway. Follow-up cross-omic analysis of VF-DMPs integrating genetics, gene expression, metabolomics, diet, and metabolic traits highlighted VF-DMPs located in 9 genes with strong relevance to metabolic disease mechanisms, with replication of signals in FASN, SREBF1, TAGLN2, PC and CFAP410. PC methylation showed evidence for mediating effects of diet on VF. FASN DNA methylation exhibited putative causal effects on VF that were also strongly associated with insulin resistance and methylation levels in FASN better classified insulin resistance (AUC=0.91) than BMI or VF alone.

Conclusions

Our findings help characterise the adiposity-associated methylation signature of SAT, with insights for metabolic disease risk.
Severe dysphagia after a posterior cervical spine fusion at the C1–C3 level and its improvement after correction surgery for malalignment: a case report
Authors: Suvithayasiri Siravich , Decharin Payothorn
Published: July 2022

Background

The development of dysphagia and trismus following posterior C1–C3 fusion is rare compared to occipitocervical fusion, and there are very few reports in the literature.

Case presentation

A 75-year-old Thai man who had an extradural tumor at the C1/C2 level developed severe dysphagia and trismus immediately after tumor resection and C1–C3 fusion. During the surgery for malalignment correction, the C1–C2 screws were re-aligned into an increased lordotic position. The symptoms resolved immediately post-surgery.

Conclusions

Short upper cervical fusion can produce trismus and dysphagia in a relatively flexed position. Preoperative planning should be individualized based on the patient’s resting neutral alignment to prevent complications.
Sulfate-reducing bioreactors subjected to high sulfate loading rate or acidity: variations in microbial consortia
Authors: Salo Marja , Bomberg Malin
Published: July 2022

Sulfate-reducing bioreactors are used in e.g. the mining industry to remove sulfate and harmful metals from process waters. These bioreactors are expected to be run for extended periods of time and may experience variations in the influent quality, such as increasing sulfate loading rate and decrease in pH, while being expected to function optimally. In this study we followed the sulfate removal rate and variation in microbial communities over a period of up to 333 days in three different up-flow anaerobic sludge blanket (UASB) bioreactors being submitted to increasing sulfate loading rate or decreasing pH. Sodium lactate was used as the sole carbon source and electron donor. All three bioreactors contained highly diverse microbial communities containing archaea, fungi and bacteria. Sulfurospirillum and Desulfovibrio were the most prominent bacterial genera detected in the bioreactors receiving the highest sulfate loading rates, and the greatest relative abundance of methanogenic archaea and the fungal genus Cadophora coincided with the highest sulfate reduction rates. In contrast, Sulfuricurvum was dominant in the bioreactor receiving influent with alternating pH, but its relative abundance receded in response to low pH of the influent. All bioreactors showed excellent sulfate removal even under extreme conditions in addition to unique responses in the microbial communities under changing operational conditions. This shows that a high diversity in the microbial consortia in the bioreactors could make the sulfate removal process less sensitive to changing operational conditions, such as variations in influent sulfate loading rate and pH.
A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose
Authors: Sbardella Diego , Tundo Grazia Raffaella , Mecchia Alice , Palumbo Camilla , Atzori Maria Grazia , Levati Lauretta , Boccaccini Alessandra , Caccuri Anna Maria , Cascio Paolo , Lacal Pedro Miguel , Graziani Grazia , Varano Monica , Coletta Massimiliano , Parravano Mariacristina
Published: July 2022

Background

Diabetic retinopathy (DR) is a microvascular complication of diabetes with a heavy impact on the quality of life of subjects and with a dramatic burden for health and economic systems on a global scale. Although the pathogenesis of DR is largely unknown, several preclinical data have pointed out to a main role of Muller glia (MG), a cell type which spans across the retina layers providing nourishment and support for Retina Ganglion Cells (RGCs), in sensing hyper-glycemia and in acquiring a pro-inflammatory polarization in response to this insult.

Results

By using a validated experimental model of DR in vitro, rMC1 cells challenged with high glucose, we uncovered the induction of an early (within minutes) and atypical Nuclear Factor-kB (NF-kB) signalling pathway regulated by a calcium-dependent calmodulin kinase II (CamKII)-proteasome axis. Phosphorylation of proteasome subunit Rpt6 (at Serine 120) by CamKII stimulated the accelerated turnover of IkBα (i.e., the natural inhibitor of p65-50 transcription factor), regardless of the phosphorylation at Serine 32 which labels canonical NF-kB signalling. This event allowed the p65-p50 heterodimer to migrate into the nucleus and to induce transcription of IL-8, Il-1β and MCP-1. Pharmacological inhibition of CamKII as well as proteasome inhibition stopped this pro-inflammatory program, whereas introduction of a Rpt6 phospho-dead mutant (Rpt6-S120A) stimulated a paradoxical effect on NF-kB probably through the activation of a compensatory mechanism which may involve phosphorylation of 20S α4 subunit.

Conclusions

This study introduces a novel pathway of MG activation by high glucose and casts some light on the biological relevance of proteasome post-translational modifications in modulating pathways regulated through targeted proteolysis.
Emoji as promising tools for emotional evaluation in orthodontics
Authors: Marañón-Vásquez Guido Artemio , Maia Lucianne Cople , Barreto Luísa Schubach da Costa , da Cruz Mariana Farias , Jural Lucas Alves , Araújo Mônica Tirre de Souza , Pithon Matheus Melo
Published: July 2022

Background

Emoji are pictograms frequently used in social networks capable of expressing emotions. These tools can provide insights into people's behavior that could not be obtained with the use of textual communication. Recently, emoji have been introduced to various research fields as successful alternatives to word-based questionnaires for measure emotional responses. The objective of this study was to preliminarily evaluate the discriminating ability and relationship of these tools with different occlusal conditions/malocclusions.

Methods

Online surveys were applied to adult individuals (n = 201; mean age = 27.4 ± 5.7; 37.3% males, 62.7% females). Subjects issued acceptance scores (10-point scale) and expressed their emotional status using a 30-emoji list in relation to nine occlusal conditions: C1–crowding, C2–anterior open bite, C3–interincisal diastema, C4–increased overjet + deep bite (Class II div. 1), C5–anterior crossbite (Class III), C6–ideal occlusion, C7–unilateral posterior crossbite, C8–anterior open bite plus bilateral posterior crossbite plus crowding, and C9–deep bite (Class II div. 2). Cochran's Q and McNemar tests were used to compare the frequencies of choice of emoji between conditions. Correspondence analyses were applied to assess the association between occlusal conditions and emoji. Kendall's correlation coefficient was calculated to evaluate the relationship between mean acceptance scores and frequency counts of each emoji.

Results

The frequency of choice between conditions showed a significant difference for 25 of the 30 emoji (P < 0.05), indicating an adequate discriminating ability of these tools. Emoji were grouped predominantly based on their emotional valence (positive/negative) and arousal/activation (high/low). Positive emoji were associated with the most accepted conditions (i.e., C6, C3), while negative emoji with the most rejected ones (i.e., C8, C1, C2). Although only weak, positive correlations between acceptance and positively valenced emoji, and negative correlations between acceptance and negatively valenced emoji were observed (P < 0.05).

Conclusions

Emoji have an adequate discriminatory ability and would allow determining emotional profiles in the face of different occlusal conditions. Further research is necessary to consolidate the use of these tools in an instrument that allows measuring emotional responses.
68Ga-PSMA-11 PET/MRI versus multiparametric MRI in men referred for prostate biopsy: primary tumour localization and interreader agreement
Authors: Ferraro Daniela A. , Hötker Andreas M. , Becker Anton S. , Mebert Iliana , Laudicella Riccardo , Baltensperger Anka , Rupp Niels J. , Rueschoff Jan H. , Müller Julian , Mortezavi Ashkan , Sapienza Marcelo T. , Eberli Daniel , Donati Olivio F. , Burger Irene A.
Published: July 2022

Background

Magnetic resonance imaging (MRI) is recommended by the European Urology Association guidelines as the standard modality for imaging-guided biopsy. Recently positron emission tomography with prostate-specific membrane antigen (PSMA PET) has shown promising results as a tool for this purpose. The aim of this study was to compare the accuracy of positron emission tomography with prostate-specific membrane antigen/magnetic resonance imaging (PET/MRI) using the gallium-labeled prostate-specific membrane antigen (68Ga-PSMA-11) and multiparametric MRI (mpMRI) for pre-biopsy tumour localization and interreader agreement for visual and semiquantitative analysis. Semiquantitative parameters included apparent diffusion coefficient (ADC) and maximum lesion diameter for mpMRI and standardized uptake value (SUVmax) and PSMA-positive volume (PSMAvol) for PSMA PET/MRI.

Results

Sensitivity and specificity were 61.4% and 92.9% for mpMRI and 66.7% and 92.9% for PSMA PET/MRI for reader one, respectively. RPE was available in 23 patients and 41 of 47 quadrants with discrepant findings. Based on RPE results, the specificity for both imaging modalities increased to 98% and 99%, and the sensitivity improved to 63.9% and 72.1% for mpMRI and PSMA PET/MRI, respectively. Both modalities yielded a substantial interreader agreement for primary tumour localization (mpMRI kappa = 0.65 (0.52–0.79), PSMA PET/MRI kappa = 0.73 (0.61–0.84)). ICC for SUVmax, PSMAvol and lesion diameter were almost perfect (≥ 0.90) while for ADC it was only moderate (ICC = 0.54 (0.04–0.78)). ADC and lesion diameter did not correlate significantly with Gleason score (ρ = 0.26 and ρ = 0.16) while SUVmax and PSMAvol did (ρ =  − 0.474 and ρ =  − 0.468).

Conclusions

PSMA PET/MRI has similar accuracy and reliability to mpMRI regarding primary prostate cancer (PCa) localization. In our cohort, semiquantitative parameters from PSMA PET/MRI correlated with tumour grade and were more reliable than the ones from mpMRI.
Extracranial metastasis of recurrent glioblastoma to the parotid gland: a case report and review of the literature
Authors: Baskurt Ozan , Kurtulus Yunus , Yavuz Ahmed Yasin , Avci İdris
Published: July 2022

Background

Glioblastomas are the most common and highly malignant primary brain tumors in adults with a median survival of 15 months even with appropriate treatment. Extracranial metastases are extremely rare due to the poor prognosis not allowing sufficient time to spread. We report an extremely rare case of extracranial metastasis of supra-tentorial glioblastoma involving the skin, subcutaneous and muscular layers, periauricular region and parotid gland, and review the literature. A total of 13 glioblastoma parotid gland metastases cases have been hitherto described.

Main body of the abstract

A 42-year-old man underwent surgery for right temporal glioblastoma and received 60 Gy/30 fractions radiotherapy together with temozolomide at 75 mg/m2. Seven months later, the tumor relapsed and the patient underwent a second surgery while chemotherapy continued. Fifteen months later, he complained of swelling in the right neck region. Fine needle aspiration and tru-cut biopsy revealed a high-grade malignant tumor infiltration within the parotid gland. Despite salvage chemotherapy and adjuvant radiotherapy, in his follow-up after 6 months neck swelling increased. The patient declined any treatment modality and continues his life 39 months after the primary diagnosis of intracranial glioblastoma.

Short conclusion

Due to the recurrence rate of intracranial glioblastoma and its malignant nature; close imaging follow-up is highly crucial. The increase in reported cases of its extracranial metastases is generally due to the modern diagnostic tools and prolonged survival attributed to the improvement in treatment modalities where now radical surgery with adjuvant radiotherapy and chemotherapy is standard protocol. Patients with glioblastomas presenting with swelling in the cervical region should be investigated to rule out parotid gland metastasis.
A experiência de curso de capacitação para promoção da atividade física na atenção primária à saúde
Authors: Porto Luiz Guilherme Grossi , Ugliara Lucas , Cunha Rafael Rodrigues da , Caetano Junior Marco Antonio , Celes Rodrigo Souza , Vieira Amilton
Published: July 2022

Evidências demonstram a importância de estratégias de promoção da atividade física no contexto da atenção primária à saúde (APS) e a carência de qualificação profissional específica nesta área. Objetivou-se relatar a experiência de um curso básico de capacitação para condução de aulas coletivas junto ao estudo piloto do Programa Brasil em Movimento, do Ministério da Saúde (PBM). O curso abrangeu oito temas com carga de 22 horas oferecidas remotamente. Em 21 dias de divulgação inscreveram-se 630 pessoas, com média de 439 visualizações das aulas. Os discentes avaliaram o curso positivamente (95%) e o recomendariam (93%). Observou-se que: 1- o número de inscritos e de visualizações das aulas indicam interesse por este tipo de qualificação; 2- a oferta do curso de modo remoto foi adequada para atingir interessados de todas regiões do Brasil; 3- a oferta desse tipo de capacitação parece ser fundamental, frente à heterogeneidade de formação do público alvo.
Directions to the Outskirts of Town: Punk Rock Tour Diaries from Nineties North America, Welly Artcore (2021)
Authors: Bestley Russ
Published: July 2022

Review of: Directions to the Outskirts of Town: Punk Rock Tour Diaries from Nineties North America, Welly Artcore (2021)

Ticehurst: Earth Island Books, 316 pp.,

ISBN 978-1-83835-674-3, p/bk, GBP £14.99
Fractured and elliptical sensibilities: An interview with Steve Taylor
Authors: Loydell Rupert
Published: July 2022

This interview contextualizes the work of Steve Taylor, within and without the Christian music industry, as solo musician, band member, producer, video artist and filmmaker. The discussion touches upon faith, satire, performance, controversy, the music business, influences and the craft of songwriting.
Electric Wizards: A Tapestry of Heavy Music, 1968 to the Present, J. R. Moores (2021)
Authors: Paschos Yorgos
Published: July 2022

Review of: Electric Wizards: A Tapestry of Heavy Music, 1968 to the Present, J. R. Moores (2021)

London: Reaktion Books Ltd, 480 pp.,

ISBN 978-1-78914-448-2, h/bk, GBP £20.00
Red Days: Popular Music & the English Counterculture 1965–1975, John Roberts (2020)
Authors: Erraught Stan
Published: July 2022

Review of: Red Days: Popular Music & the English Counterculture 1965–1975, John Roberts (2020)

Colchester and New York: Minor Compositions, 197 pp.,

ISBN 978-1-57027-364-3, p/bk, GBP £18.00
PUNK! Las Américas Edition, Olga Rodríguez-Ulloa, Rodrigo Quijano and Shane Greene (eds) (2021)
Authors: Makagon Daniel
Published: July 2022

Review of: PUNK! Las Américas Edition, Olga Rodríguez-Ulloa, Rodrigo Quijano and Shane Greene (eds) (2021)

Bristol: Intellect, 394 pp.,

ISBN 978-1-78938-415-4, h/bk, GBP £80.00
Faster! Louder! How a Punk Rocker from Yorkshire Became British Champion Fell Runner, Boff Whalley (2021)
Authors: Bestley Russ
Published: July 2022

Review of: Faster! Louder! How a Punk Rocker from Yorkshire Became British Champion Fell Runner, Boff Whalley (2021)

Bradford: Great Northern Books, 232 pp.,

ISBN 978-1-91210-129-0, p/bk, GBP £9.99
Surveillance of the spread of avian influenza virus type A in live bird markets in Tripoli, Libya, and determination of the associated risk factors
Authors: Kammon Abdulwahab , Doghman Mosbah , Eldaghayes Ibrahim
Published: July 2022

Background and Aim: Studies on avian influenza virus (AIV) in Libya are few and limited. This study aimed to determine the presence of AIV in live bird markets (LBMs) in Tripoli and determine the risk factors associated with AIV spread.

Materials and Methods: In total, 269 cloacal swabs were randomly collected from different bird species in 9 LBMs located in Tripoli and its surrounding regions. The target species were ducks, geese, local chickens, Australian chickens, Brahma chickens, turkeys, pigeons, quails, peacock broiler chicks, and pet birds. Total RNA was extracted from the swab samples and used for real-time polymerase chain reaction to detect AIV type A.

Results: Of the 269 samples, 28 (10.41% of total samples) were positive for AIV type A. The LBMs with positive samples were Souq Aljumaa, Souq Alkhamees, Souq Althulatha, and Souq Tajoura. The highest percentage (35.71%) of AIV was recorded in Souq Aljumaa. Positive results for AIV type A were obtained primarily in three species of birds: Ducks (14/65; highest percentage: 21.5%), local chickens (12/98; 12.24%), and geese (2/28; 7.14%). Furthermore, the following three risk factors associated with the spread of AIV type A were identified: Time spent by breeders/vendors at the market (odds ratio [OR] = 11.181; 95% confidence interval [CI] = 3.827–32.669), methods used for disposing dead birds (OR = 2.356; 95% CI = 1.005–5.521), and last visited LBM (OR = 0.740; 95% CI = 0.580–0.944). Restricting the movement of poultry vendors from one market to another may protect against AIV spread.

Conclusion: The findings of this study indicate the high risk of AIV spread in LBMs and highlight the need for continuous surveillance of LBMs across the country.
LINGUISTIK KOMPUTASI SEBAGAI DISIPLIN ILMU DAN RESPONS AKADEMIK DI LINGKUNGAN PERGURUAN TINGGI DI INDONESIA
Authors: Musthofa Musthofa
Published: July 2022

This paper describes an epistemological perspective of a new discipline in applied linguistics studies called "computational linguistics," the challenge and response faced by Indonesian linguists, and his problems in developing it. The analysis is carried out by utilizing epistemological concepts and theories, combined with Gianluca Carnabuci's theory called "knowledge hybridization" and the "challenge and response" theory proposed by Arnold J. Toynbee. The results show that epistemologically, computational linguistics has the validity to be called a scientific discipline. However, the response of Indonesian academics to its existence is still inadequate. This is related to the various challenges they face. For this reason, it is necessary to make multiple efforts to overcome it.
Kinetic Modeling and Optimization of Biomass Gasification in Bubbling Fluidized Bed Gasifier Using Response Surface Method
Authors: Tulu Tolossa Kebede , Atnaw Samson Mekbib , Bededa Robera Daba , Wakshume Demeke Girma , Ancha Venkata Ramayya
Published: July 2022

This paper presents the kinetic modeling of biomass gasification in bubbling fluidized bed (BFB) gasifiers and optimization methods to maximize gasification products. The kinetic model was developed based on two-phase fluidization theory. In this work, reaction kinetics, hydrodynamic conditions, convective and diffusion effect, and the thermal cracking of tar kinetics were considered in the model. The model was coded in MATLAB and simulated. The result depicted good agreement with experimental work in literature. The sensitivity analysis was carried out and the effect of temperature ranging from 650  to 850  and steam to biomass ratio (S/B) ranging from 0.1 to 2 was investigated. The result showed that an increase in temperature promoted H2 production from 18.73 % to 36.87 %, reduced that of CO from 39.97 % to 34.2 %, and CH4 from 18.01 % to 11.65 %. Furthermore, surface response was constructed from the regression model and the mutual effect of temperature and S/B on gasification products and heating value was investigated. In addition, the desirability function was employed to optimize gasification product and heating value. The maximum gasification product yield was obtained at 827.9  and 0.1 S/B. The response predicted by desirability function at these optimum operational conditions was 30.1 %, 44.1 %, 13.2 %, 12.9 %, 14.035 MJ/Nm3, and 14.5 MJ/Nm3 for H2, CO, CO2, CH4, LHV, and HHV, respectively. Kinetic modeling of the biomass gasification in BFB process is still under development, which considers the diffusion effect, tar cracking, reaction kinetics, and hydrodynamic behavior. Moreover, the large number of previous studies gave priority to a single parameter investigation. However, this investigation can be extended to various parameters analysis simultaneously, which would give solid information on system performance analysis.
Performance Evaluation of An Electrolyte-Supported Intermediate-Temperature Solid Oxide Fuel Cell (IT-SOFC) with Low-Cost Materials
Authors: Yusupandi Fauzi , Devianto Hary , Widiatmoko Pramujo , Nurdin Isdiriayani , Yoon Sung Pil , Lim Tae-Hoon , Arif Aditya Farhan
Published: July 2022

Intermediate temperature solid oxide fuel cell (IT-SOFC) provides economic and technical advantages over the conventional SOFC because of the wider material use, lower fabrication cost and longer lifetime of the cell components. In this work, we fabricated electrolyte-supported IT-SOFC using low-cost materials such as calcia-stabilized zirconia (CSZ) electrolyte fabricated by dry-pressing, NiO-CSZ anode and Ca3Co1.9Zn0.1O6 (CCZO) cathode produced through brush coating technique. According to the XRD result, the monoclinic phase dominated over the cubic phase, and the relative density of the electrolyte was low but the hardness of the CSZ electrolyte was close to the hardness of commercial 8YSZ electrolyte. The performance of the single cell was performed with hydrogen ambient air. An open-circuit voltage (OCV) of 0.43, 0.46, and 0.45 V and a maximum power density of 0.14, 0.50, and 1.00 mW/cm2 were achieved at the operating temperature of 600, 700, and 800 °C, respectively. The ohmic resistance of the cell at 700 and 800 °C achieved 81.5 and 33.00 Ω, respectively due to the contribution of thick electrolyte and Cr poisoning in electrodes and electrolyte
Review of Eat local, taste global: how ethnocultural food reaches our tables
Authors: Zink Regan
Published: July 2022

Eat Local, Taste Global: How Ethnocultural Food Reaches our Tables, by Glen C. Filson and Bamidele Adekunle, addresses the demand, availability, and production of ethnocultural vegetables in the Greater Toronto and Hamilton Area (GTHA). The book is centered around the three largest ethnic groups in the GTHA (Chinese, South Asian, Afro-Caribbean) and considers histories of immigration, acculturation, and the availability of ethnocultural food. Taken as a whole, this book provides an overview and justification for the local production of ethnocultural vegetables. While this book is primarily based in the Southern Ontario context, there is some discussion of ethnocultural vegetable value chains in other parts of Canada and the USA. Further, Filson and Adekunle distinguish between the corporate food regime, characterized by longer value chains, and local and community level food sovereignty which are primarily discussed through farmers’ markets, community shared agriculture, and gardening. The authors cite numerous benefits of producing ethnocultural vegetables in Southern Ontario, including economic, health, social, and environmental benefits. Ethnocultural vegetables are not only fresher and more nutritious when produced locally, but there is also increased opportunity for producer-consumer contact and less food miles associated with local production.
Engineered nanoparticles eluding bacteria to obliteration
Authors: R Biswas
Published: July 2022

This concise report briefs about engineered inorganic nanoparticles. The principle of operation as well as reaction kinetics is also highlighted here.
Vision and Concussion: Symptoms, Signs, Evaluation, and Treatment
Authors: Master Christina L. , Bacal Darron , Grady Matthew F. , Hertle Richard , Shah Ankoor S. , Strominger Mitchell , Whitecross Sarah , Bradford Geoffrey E. , Lum Flora , Donahue Sean P. ,   AAP SECTION ON OPHTHALMOLOGY; AMERICAN ACADEMY OF OPHTHALMOLOGY; AMERICAN ASSOCIATION FOR PEDIATRIC OPHTHALMOLOGY AND STRABISMUS; and AMERICAN ASSOCIATION OF CERTIFIED ORTHOPTISTS
Published: July 2022

Visual symptoms are common after concussion in children and adolescents, making it essential for clinicians to understand how to screen, identify, and initiate clinical management of visual symptoms in pediatric patients after this common childhood injury. Although most children and adolescents with visual symptoms after concussion will recover on their own by 4 weeks, for a subset who do not have spontaneous recovery, referral to a specialist with experience in comprehensive concussion management (eg, sports medicine, neurology, neuropsychology, physiatry, ophthalmology, otorhinolaryngology) for additional assessment and treatment may be necessary. A vision-specific history and a thorough visual system examination are warranted, including an assessment of visual acuity, ocular alignment in all positions of gaze, smooth pursuit (visual tracking of a moving object), saccades (visual fixation shifting between stationary targets), vestibulo-ocular reflex (maintaining image focus during movement), near point of convergence (focusing with both eyes at near and accommodation (focusing with one eye at near because any of these functions may be disturbed after concussion. These deficits may contribute to difficulty with returning to both play and the learning setting at school, making the identification of these problems early after injury important for the clinician to provide relevant learning accommodations, such as larger font, preprinted notes, and temporary use of audio books. Early identification and appropriate management of visual symptoms, such as convergence insufficiency or accommodative insufficiency, may mitigate the negative effects of concussion on children and adolescents and their quality of life.
Capital market Stability after the Adoption of International Financial Reporting Standards: Focusing on the mediating effect of conservatism
Authors:   The Korea International Trade Research Institute, Bae Jin-Cheol , Kim Myung-In , Choi Su-Young
Published: July 2022

Purpose This study examines the effect of the International Financial Reporting Standards (IFRS), which has been mandatory since 2011 for listed companies, on the stock price crash through conservatism. Design/Methodology/Approach The stability of the capital market was measured by stock price crash, and Khan and Watts (2009)’s method of measuring the level of conservatism was used. To verify the mediating effect, regression analysis was performed 3 times, and the results of the sobel test were also confirmed. Findings As a direct effect, IFRS adoption was found to increase the stock price crash in the stock market. The level of conservatism has decreased due to IFRS adoption. Conservatism has been found to be a parameter between IFRS adoption and the stock price crash. Research Implication This study is meaningful in that it examines the effect of IFRS adoption on the changes in the information environment of Korean companies, that is, the stock price crash. It was revealed that the level of conservatism after IFRS adoption is an important factor in the stability of the capital market.
A Study on the Utilization and Performance of Online Export Marketing Support System for SMEs: A Focus on Daejeon, Sejong, and the Chungnam Provinces
Authors:   The Korea International Trade Research Institute, Heo Seong-Ho , Choi Jang-Woo
Published: July 2022

Purpose This study identifies and investigates the online marketing support system of SMEs in Daejeon, Sejong, and Chungnam Provinces, South Korea, and present policy guidelines to improve the system by considering the operational conditions of the system and characteristics of the export entities. Design/Methodology/Approach This study was conducted to design a research model and find which core factors have influence on the performance of exporters of SMEs by reviewing previous studies and literature. Further, we examine an empirical research particularly targeting online based overseas marketing support systems. Findings Under the current social distancing situation caused by COVID-19, the online export marketing support system provided by the government and local agency have become more important. We verified that the characteristics and recognition of the support system had a significant impact on actual export performance by examining the current status of export SMEs in the region. We also confirmed that the use of the online export support marketing support system had positive effects on the export performance of SMEs. Research Implications In order for SMEs to achieve actual export performance, the government needs to continue to pay attention to and improve the online export marketing support system. In particular, programs implemented at each local government unit should be further customized and promote overseas orientation for corporate representatives, executives, and employees. Duplication between programs should be avoided and differentiated projects should be provided. This online export marketing system review provides empirical research on the use and performance of the government support system.
Las prácticas externas en títulos universitarios de formación del profesorado
Authors: Belmonte Otero Isabel , Castro Pais Mª Dolores , Mallo Rey Marta Mª
Published: July 2022

Dentro del Proyecto ECALFOR, integrado por un consorcio internacional de 19 instituciones de nueve países de Latinoamérica, Caribe y Europa, se ha realizado una evaluación comparativa de los planes de estudio de los títulos universitarios de formación del profesorado. Uno de los aspectos analizados ha sido el desarrollo de las prácticas externas, también denominadas prácticas pre-profesionales o pasantías, como parte de la formación de los futuros docentes. El principal objetivo de este análisis temático es extraer información sobre el proceso de desarrollo de las prácticas en las titulaciones universitarias de formación de profesorado para así tener una base sólida para la toma de decisiones sobre futuras políticas y procesos de aseguramiento de la calidad universitaria. Se ha llevado a cabo una revisión, mediante la metodología de análisis de contenido, de los autoinformes de cada una de las instituciones participantes en el proyecto pudiendo concluir que existe una gran oscilación entre el número de horas de prácticas externas en los distintos planes de estudio analizados (la duración media de las prácticas en centros/escuelas es de 510 horas, oscilando desde 160 horas en los planes de estudio con menor carga hasta 1200 horas en aquellos que apuestan por una formación más práctica); sin embargo, en lo referente a la supervisión del alumnado, en la mayoría de las instituciones la tutorización es compartida entre la Universidad y el centro de prácticas, independientemente del país o las características de la universidad donde se imparte el título.
Indicadores bibliométricos de la actividad física como beneficio saludable en mayores
Authors: Ortega Caballero Manuel , Ubago Jiménez José Luis , Puertas Molero Pilar , González Valero Gabriel , Melguizo Ibáñez Eduardo , Valverde Janer Marina
Published: July 2022

Ya desde mediados del siglo pasado observamos cambios demográficos significativos, con propensión progresiva en cuanto al envejecimiento de la población, la supervivencia se trata de un aspecto presente del tiempo en el que vivimos y de una nueva composición social. Por ello se lleva a cabo una revisión sistemática con el objetivo de analizar los beneficios que tiene la actividad física sobre los mayores y su calidad de vida. Se realizó una búsqueda científica en la Web of Science comprendiendo sólo publicaciones del último lustro con mayor índice de impacto. Se analizaron una cantidad de artículos y revisiones diez veces mayor para incluir por último en quince artículos. Los resultados dejaron claro que la actividad física en personas mayores auxilia numerosos beneficios físicos y psicológicos para la salud. También se demostró que las personas mayores activas presentan una bajada de las sintomatologías depresivas y mejoran la autosuficiencia es decir una vida más saludable.
Levels of Covid fear in a sample of adolescents: does mental health literacy helps?
Authors: Vale Dias Maria da Luz , Maia de Carvalho Mariana
Published: July 2022

Background: The Covid-19 pandemic generated great fear and anxiety across the world. Debates concerning mental health promotion and mental illness prevention have reinforced the importance of promoting mental health literacy and providing psychological help to the population. Nonetheless, no study has examined the effect of mental health literacy and psychological help in levels of fear of covid. Aims: This study aims to explore the relationship between literacy about mental illness, literacy about mental well-being, having consulted a psychologist / psychiatrist in the past and levels of fear of covid, in a sample of Portuguese adolescents. Methods: Using cross-sectional design we collected a sample of 345 adolescents (53.2% of the participants are female) aged between 15-18 years old, that filled during the months of May-June 2021 an online survey composed of a sociodemographic questionnaire, two mental health literacy scales – one measuring literacy about mental illness (Mental Health Literacy Questionnaire - MHLq), one measuring literacy about mental well-being (Positive Mental Health Literacy Questionnaire - PosMHLit) - and two questionnaires measuring coronavirus anxiety and fear of Covid (CAS and FCV-19S). In order to assess professional psychological help,subjects werealso asked if they had consulted a psychologist or psychiatrist in the past. Results: Fear of covid is related to mental health literacy and having psychological support in the past. Results from multiple regression analysis, on the other hand, suggest that variance in fear of covid is better explained by sociodemographic variables, such as gender, than by mental health literacy. Conclusions: Exploring the main findings and the relationships between variables, the implications of the results will be addressed.
Perfil de competência emocional de enfermeiros em contexto de reclusao
Authors: Fernandes Sara , Caçador Anastácio Zélia
Published: July 2022

A vivência do cuidar da população reclusa, desenvolve-se num ambiente com características específicas, despertando nos enfermeiros sentimentos por vezes ambivalentes que estes necessitam ter a capacidade para gerir. Esta gestão, necessita do desenvolvimento de um conjunto de competências e recursos que dizem respeito à Competência Emocional. O objetivo geral deste estudo foi conhecer o perfil de competência emocional dos enfermeiros em contexto prisional e os objetivos específicos foram: apresentar as variáveis sociodemográficas da amostra, conhecer a relação entre variáveis sociodemográficas e profissionais e o perfil de competência emocional dos enfermeiros em contexto prisional. O estudo é do tipo quantitativo, de carácter descritivo e analítico. Teve como critérios de inclusão enfermeiros que trabalhavam no momento nos Estabelecimentos Prisionais do Porto, Santa Cruz do Bispo e Paços de Ferreira. O instrumento de recolha de dados foi um questionário que se encontra dividido em duas partes. A primeira parte era composta por questões que contemplam variáveis sociodemográficas e profissionais e a segunda parte foi composta pela “Escala Veiga de CE” (EVCE) (Veiga-Branco,1999). A amostra deste estudo foi constituída por 17 enfermeiros, na sua maioria do sexo feminino (52.9%). A grande maioria exercia funções no estabelecimento prisional do Porto (76.5%). Verificou-se existir relação entre a variável sociodemográfica estado civil e a dimensão Automotivação. Com a variável, tempo médio diário de contacto com reclusos também se obtiveram diferenças estatisticamente significativas nas dimensões Autoconsciência, Automotivação e Competência Emocional Global. A satisfação profissional também apresentou diferenças estatisticamente significativas em todas as variáveis dependentes, exceto na Automotivação e na Empatia. Em relação aos determinantes da Competência Emocional, confirmou-se que todas as dimensões são preditivas da mesma e que os enfermeiros apresentam níveis moderados de competência emocional nas suas cinco vertentes e globalmente. A dimensão “Autoconsciência”, apresentou alto nível de Competência emocional.
Adaptaçao ao ensino à distância e competências socioemocionais de professores/educadores portugueses em confinamento por Covid-19
Authors: Caçador Anastácio Zélia , Antao Celeste , Cramês Luísa
Published: July 2022

Esta investigação pretendeu caraterizar a capacidade de adaptação ao ensino à distância e competências socioemocionais de professoreseeducadores-de-infância no primeiro período deconfinamento devido à COVID-19, bem como averiguar a influência de fatores individuais e socioprofissionais nessas competências pessoais. Tratou-se de um estudo transversal, descritivo e correlacional, com uma metodología mista de análise de dados. Aplicou-se um questionário misto, com umas questões fechadas e outras abertas, on-line, incluindo a escala Wong and Law Emotional Intelligence Scale previamente validada para a população adulta Portuguesa, assim como várias questões de caracterização sociodemográfica e outras relacionadas com a percepção de adaptação dos professores ao ensino à distância. A amostra incluiu um total de 302 professores/educadores (245 mulheres e 57 homens), predominando os grupos etários 41-50 (43.7%) e 51-60 anos (38.1%) e o nível de ensino secundário (27.8%). A dimensão de competência emocional em que os professores/educadores registaram média mais baixa foi regulação das emoções (M=3.21). Para trabalhar à distância salientaram-se dificuldades relacionadas com o domínio das tecnologias, os alunos e os métodos de ensino. Sem diferenças significativas em função do nível de ensino, notou-se dificuldade de regulação de emoções em todos os grupos, concluindo-se que esta problemática tendeu a afetar globalmente todos os professores / educadores.
Afectación psicológica de los profesionales sanitarios de la gerencia de emergencias sanitarias de Castilla y León durante la pandemia Covid-19
Authors: Soto Cámara Raúl
Published: July 2022

Objetivo: Analizar los niveles de estrés, ansiedad y depresión de los profesionales sanitarios del Servicio de Emergencias Médicas (SEM) de Castilla y León durante la pandemia por COVID-19, así como determinar su asociación con determinados factores. Métodos: Estudio descriptivo transversal en el que se incluyeron a todos los profesionales sanitarios que entre el 01/02/2021 y el 30/04/2021 se encontraban trabajando en el SEM de Castilla y León. Sus niveles de estrés, ansiedad y depresión, evaluado mediante la escala DASS-21, fueron los resultados principales del estudio. Se recogieron también variables socio-demográficas, laborales y relacionadas con la COVID-19 y se estudió su posible asociación con las variables psicológicas citadas mediante un análisis univariante y multivariante. Resultados: Los profesionales sanitarios del SEM obtuvieron una puntuación media de 19.60 (DE ± 11.14) para estrés, 12.30 (DE ± 11.45) para ansiedad y 15.14 (DE ± 11.52) para depresión. Ser mujer se asoció con valores graves o extremadamente graves de estrés (OR 1.861; IC95% 1.026-3.377), ansiedad (OR 3.319; IC95% 1.696-6.495) y depresión (OR 2.334; IC95% 1.275-4.272); haber precisado psicoterapia y/o psicofármacos previamente, con valores graves o extremadamente graves de estrés (OR 4.762; IC95% 2.332-9.728) y ansiedad (OR 4.059; IC95% 1.921-8.576); mientras que trabajar como TES, con valores graves o extremadamente graves de ansiedad (OR 5.143; IC95% 2.633- 10.049) y depresión (OR 2.211; IC95% 1.220-4.004). Conclusión: Los profesionales sanitarios del SEM de Castilla y León presentaron niveles medios-elevados de estrés, ansiedad y depresión durante la pandemia. Existen factores socio-demográficas, laborales y relacionados con la COVID-19 que se asocian con una mayor afectación psicológica.
Agri-food supply chain holistic design: an application
Authors: Tumenbatur Atiye , Tanyas Mehmet , Cakmak Emre
Published: July 2022

Purpose- Agri-food supply chain is an important supply chain for our country in terms of both cost and food safety. In this context, the selection of suppliers, manufacturers and logistics companies that make up the chain and the relations between them are extremely important, and the quality of the companies that make up the chain must be high in order to create effective and efficient supply chains. In this study, the author aimed to conduct a research on the creation of an integrated supply chain with a collaborative approach. The framework of the study is limited to the producers, suppliers and logistics enterprises, which are the main actors in the agriculture-food value chain.
Methodology- The author proposes an integrated methodology for collaborative work in the agri-food supply chain. Within the framework of the methodology created within the framework of the CPFR method, the chains that enable the stakeholders included in the system to deliver the product to the demand points at the most affordable cost were determined by the linear programming model. In the second stage, meeting the demands created with random numbers was simulated. Finally, the suitability of the model was tested with the data of a company.
Findings- The findings show that the product moves less if the stakeholders in the chain are correctly matched within the framework of the collaborative approach. In addition, it has been seen that the needs of both demand points are met thanks to the correct match. In addition, a positive effect has been achieved in the use of the stakeholders' capacities.
Conclusion- This article is one of the first studies that looks at the agri-food supply chain in an integrated way and evaluates the processes within the framework of a collaborative approach. The study also contributes to improvement in the sector in terms of including the stakeholders involved in the collaborative process into the system according to the criteria determined.

Keywords: OR in agriculture, agri-food, agri-food supply chain, holistic design, CPFR
JEL Codes: M11, Q10, S19