bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimizing BFloat16 Deployment of Tiny Transformers on Ultra-Low Power Extreme Edge SoCs
Authors: Dequino Alberto , Bompani Luca , Benini Luca , Conti Francesco
Published: February 2025

Transformers have emerged as the central backbone architecture for modern generative AI. However, most ML applications targeting low-power, low-cost SoCs (TinyML apps) do not employ Transformers as these models are thought to be challenging to quantize and deploy on small devices. This work proposes a methodology to reduce Transformer dimensions with an extensive pruning search. We exploit the intrinsic redundancy of these models to fit them on resource-constrained devices with a well-controlled accuracy tradeoff. We then propose an optimized library to deploy the reduced models using BFLoat16 with no accuracy loss on Commercial Off-The-Shelf (COTS) RISC-V multi-core micro-controllers, enabling the execution of these models at the extreme edge, without the need for complex and accuracy-critical quantization schemes. Our solution achieves up to 220× speedup with respect to a naïve C port of the Multi-Head Self Attention PyTorch kernel: we reduced MobileBert and TinyViT memory footprint up to ∼94% and ∼57%, respectively, and we deployed a tinyLLAMA SLM on microcontroller, achieving a throughput of 1219 tokens/s with an average power of just 57 mW.
Development and Operation of a Free-Fall Type Glass Sphere Underwater Observation System with Suspended Cable in the Seto Inland Sea
Authors: Atsumi Taisei , Shin Yuki , Ishiyama Takumi , Furuya Masaki , Hayashi Yousuke , Koike Yoshikazu
Published: February 2025

We have developed a free-fall type glass sphere underwater observation system with suspended cable. The developed observation system is quite simple to construct and is able to operate at deep sea because the system is structured by glass sphere. The glass sphere has high endurability. Due to no motion system like thrusters, the position of a free-fall type underwater observation system is not clear. And hence, we propose the operation of a free-fall type underwater observation system with a suspended cable like a zipline. To make the position of the system more precise, an inertial measurement unit (IMU) is installed inside the system. A router is also installed inside the system to obtain underwater pictures via a LAN cable. The observation system, which is named UWOS (Under Water Observation System), was operated in the Seto Inland Sea. It was found that the UWOS indicates the possibility of a free-fall type glass sphere underwater observation system with a suspended cable.
A Review of Maritime Nuclear Reactor Systems
Authors: Holbert Keith E.
Published: February 2025

Marine reactors have been applied to floating nuclear power plants, naval vessels such as submarines, and civilian ships such as icebreakers. Nuclear-powered shipping is gaining increased interest because of decarbonization goals motivated by climate change. Enhanced reactor safety can potentially reduce regulatory and liability challenges to the adoption of nuclear propulsion systems for merchant ships. This gives strong impetus for reviewing past use of nuclear reactor systems in marine environments, especially from the perspective of any accident scenarios, lest planners be caught unaware of historical incidents. To that end, a loss of coolant accident (LOCA) in a Lenin icebreaker reactor in 1965 and disposal at sea of some of its damaged fuel and reactor vessel as well as the entire tri-reactor compartment is recounted.
The Impact of AI-Personalized Recommendations on Clicking Intentions: Evidence from Chinese E-Commerce
Authors: Yin Jiwang , Qiu Xiaodong , Wang Ya
Published: February 2025

AI-personalized recommendation technology offers more accurate and diverse choices to consumers and increases click-through rates and sales on e-commerce platforms. Yet, data on consumers’ experiences of AI-personalized recommendations and their impact path on clicking intention are scarce. This article addressed these issues through three studies. In study 1, we adopted the Grounded Theory approach to conduct in-depth interviews with 30 Chinese consumers and constructed a scale to measure the impact of consumer experience on click intention. In study 2, we adopted the empirical research method to conduct reliability and validity tests on 347 valid questionnaires to finalize the scale officially. In study 3, based on the SOR theory, we constructed a model and formulated hypotheses and then conducted empirical analysis using 1097 valid questionnaires. We found that the relevance, inspiration, and insightful experiences of AI-personalized recommendations can significantly promote consumers’ clicking intention. Moreover, immersive experience mediates between the former three factors and clicking intention, and technology acceptance mediates between relevance, inspiration, and clicking intention. When consumers perceive a high degree of information privacy infringement, the immersive experience’s positive impact on clicking intention will be weakened. Meanwhile, the promoting effect of technology acceptance on clicking intention will also be inhibited. When information quality improves, the positive impact of technology acceptance on clicking intention will be enhanced. This research fills the gap in the literature on consumers’ experiences of AI-personalized recommendations and clarifies how these experiences affect the clicking intention. It offers valuable insights for e-commerce platforms to continuously optimize personalized recommendation algorithms and boost the click conversion rate of online shopping.
A Village-Scale Study Regarding Landscape Evolution and Ecological Effects in a Coastal Inner Harbor
Authors: Pan Qinqin , Li Saiqiang , Li Jialin , Xu Mingshan , Yang Xiaodong
Published: February 2025

The development of inner harbors has been accompanied by the destruction of natural landscapes, which in turn has led to numerous ecological problems. However, the temporal and spatial relationships between changes in the inner harbor landscape and ecological effects are not yet clear, and there are relatively few studies at smaller scales such as villages. In this study, we investigated Xieqian Harbor in Xiangshan County, along the eastern coast of China, and then analyzed the landscape change and evolutionary characteristics of the effects of carbon storage, soil conservation, and water yield at the village scale for the years 2000, 2010, and 2020. We then used the geographically and temporally weighted regression (GTWR) model to explore the spatiotemporal relationships between landscape variables and ecological effects. The results showed that the fragmentation and diversity of landscape patches increased from 2000 to 2020 due to reclamation and aquaculture, tourism development, and harbor construction, as reflected by the edge density (ED) and the Shannon diversity index (SHDI), which increased by 11.31% and 2.82%, respectively. This change resulted in a notable reduction of 572.6 thousand tons in carbon sequestration, 853 million tons in soil conservation, and 19 million cubic meters in water yield over the past 20 years. When temporal non-stationarity and spatial heterogeneity were combined, the relationship between landscape change and ecological effects became highly intricate, with varying responses across different time periods and locations. The area-weighted mean patch shape index (AWMSI) was a key factor affecting the three ecological effects. Our research confirmed that there was significant spatiotemporal heterogeneity in the effects of different landscape variables on ecological effects in inner harbors at the village scale. Compared with larger-scale studies, the results of village-scale studies revealed more precisely the impacts of localized landscape changes on ecological effects, providing support for the sustainable management of inner harbors and providing a new approach to integrating GTWR into landscape ecological time–space analysis research.
The Acute Effects of Moderate-Intensity Aerobic Exercise on Core Executive Functions in Healthy Older Adults: A Systematic Review
Authors: Çakaloğlu Erdem , Yüksel Hidayet Suha , Şahin Fatma Neşe , Güler Özkan , Arslanoğlu Erkal , Yamak Bade , Aydoğmuş Mert , Yaşar Onur Mutlu , Gürkan Alper Cenk , Söyler Mehmet , Ceylan Levent , Küçük Hamza
Published: February 2025

There is growing interest in examining acute effects of exercise on cognitive functions and neurocognitive outcomes. These behavioral and neurocognitive outcomes have been most frequently investigated in healthy young individuals, but relatively few studies have examined healthy older adults. This study aimed to systematically review the effects of acute moderate-intensity aerobic exercise (MIAE) on core executive functions, including inhibition, working memory, and cognitive flexibility, in healthy older adults. A database search of PubMed, Scopus, and Web of Science was conducted using a systematic search strategy. Acute MIAE interventions assessing core executive functions using randomized or stratified controlled trials investigating healthy older adults were reviewed. Eleven studies were identified, and the behavioral results from all included studies revealed that acute MIAE can improve core executive functions in healthy adults. However, incompatible results were observed in activated areas of the prefrontal cortex following MIAE in older adults. The limited number of studies investigating the effects of MIAE on core executive functions in older healthy adults with moderate overall quality restricts the conclusions. Therefore, more robust quality studies using neuroimaging techniques to investigate core executive functions, especially working memory and cognitive flexibility, are needed to explain the neural and behavioral mechanisms.
Anatomical-Based Filler Injection Diagnosis to Treatment Techniques: Infraorbital Groove and Hollowness
Authors: Hong Gi-Woong , Choi Wonseok , Yoon Song-Eun , Wan Jovian , Yi Kyu-Ho
Published: February 2025

Infraorbital groove and hollowness are common aging-related anatomical changes in the periorbital region, leading to a sunken and tired appearance. These conditions are caused by the progressive loss of volume in the deep fat pads, including the sub-orbicularis oculi fat (SOOF) and malar fat, along with skin thinning and decreased elasticity. Filler injections, particularly hyaluronic acid-based fillers, are the preferred treatment to restore volume and smooth the under-eye area. Proper diagnosis, understanding of anatomical variations, and accurate injection techniques are essential to avoid complications and achieve natural, esthetically pleasing outcomes. Treatments should consider the patient’s unique anatomy and potential adjunctive procedures to ensure balanced and harmonious facial rejuvenation.
(1S,1′S)-2,2′-(Benzylazanediyl)bis(1-((3aR,4R,6aR)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethan-1-ol)
Authors: Kadraoui Mohammed , Guillarme Stéphane , Saluzzo Christine
Published: February 2025

(1S,1′S)-2,2′-(Benzylazanediyl)bis(1-((3aR,4R,6aR)-2,2-dimethyltetrahydrofuro [3,4 d][1,3]dioxol-4-yl)ethan-1-ol), presenting a tertiary β-aminodiol moiety, was synthesized in 72% yield in a one-step reaction from an aminolysis of an isosorbide-derived oxirane with benzylamine. This β-aminodiol was fully characterized by 1H and 13C NMR and HRMS analyses.
A Comparison Between the Residual Stresses of Ti6Al4V and Ti-6Al-2Sn-4Zr-6Mo Processed by Laser Powder Bed Fusion
Authors: Aversa Alberta , Carrozza Alessandro , Mercurio Vincenza , Calignano Flaviana , Sereda Olha , Pejchal Vaclav , Lombardi Mariangela
Published: February 2025

Metal additive manufacturing processes induce residual stress in as-built components. These residual stresses are detrimental to part quality as they can induce defects such as warping and delamination. In some cases, when complex components are built, residual stress can even cause a build job to fail due to the recoater crashing into the distorted part. In this paper, the residual stress values of Ti6Al4V and Ti-6Al-2Sn-4Zr-6Mo alloys were evaluated by the cantilever approach and by the X-ray diffraction sin2(Ψ) method. The results showed that, as expected, Ti6Al4V as-built cantilevers displayed high distortion and von Mises equivalent stress values up to 494 MPa. On the contrary, as-built Ti-6Al-2Sn-4Zr-6Mo cantilevers were characterized by almost null warping and a residual stress value in the as-built state of 191 MPa. This different behavior is mainly due to the different properties of the hexagonal α’ martensite in Ti6Al4V and the soft orthorhombic α’’ martensite in Ti6246. The post-processing heat treatment significantly reduced the residual stress in Ti6Al4V, lowering it to 44 MPa, while, in the case of Ti-6Al-2Sn-4Zr-6Mo, the post-processing heat treatment did not affect the residual stress conditions. These findings suggest that Ti-6Al-2Sn-4Zr-6Mo could be a suitable candidate for the additive manufacturing production of extremely complex parts, as it could reduce the risks associated with recoater crashes and job failures.
Static and Fatigue Properties of Rhenium-Alloyed Inconel 718 Produced by Powder Bed Fusion Additive Manufacturing
Authors: Frankiewicz Mariusz , Karoluk Michał , Dziedzic Robert , Gruber Konrad , Stopyra Wojciech
Published: February 2025

Inconel 718 (In718) is the most widely used nickel-based alloy in additive manufacturing due to its favorable processability. However, In718’s high-temperature performance is not suited for the most demanding applications in the aerospace industry. Therefore, in this study, Inconel 718 powder was coated with 3% wt. rhenium (In718-Re) using AM’s in situ alloying capabilities to improve high-temperature properties. The proposed alloy’s mechanical performance was evaluated, focusing on the effects of post-process heat treatment and hot isostatic pressing following the laser-based powder bed fusion of metals (PBF-LB/M) processing. Static tensile tests conducted at room temperature and elevated temperatures (650 °C and 760 °C) demonstrated that the alloy has comparable strength to pure In718 according to ASTM F3055-14a—an ultimate tensile strength of 1247 MPa, yield strength of 909 MPa, and almost 2× higher elongation of 23.8%. Fatigue tests at room temperature indicated a fatigue limit below 400 MPa for 107 cycles. Fractographic analysis revealed that fatigue performance was primarily impacted by a lack of fusion defects inherent to the PBF-LB/M process, highlighting the need for optimized powder preparation and processing parameters to minimize defect formation. While rhenium addition shows limited benefits in Inconel 718, this study underscores the potential of in situ alloying through powder surface modification as a flexible method for incorporating high-melting-point elements into nickel-based alloys for tailored alloy design in additive manufacturing.
Photographic Analysis of a Low-Current, Vacuum Electric Arc Using an Ultrafast Camera
Authors: Lech Michał , Węgierek Paweł
Published: February 2025

The main component of vacuum interrupters responsible for ensuring the correct flow of current is the contact system. In a vacuum environment, due to the higher values of the mean free path of electrons and particles in the contact gap, the material and condition of the contacts exert the greatest influence on the development of the arc discharge. To accurately analyze the phenomenon of discharge development in vacuum insulating systems, the authors conducted a time-lapse photographic analysis of a vacuum electric arc. For this purpose, they used a test setup comprising a discharge chamber, a vacuum pump set, a power and load assembly, an ultra-high-speed camera, and an oscilloscope with dedicated probes. The measurement process involved connecting the system, determining the power supply, load, and measurement parameters and subsequently performing contact opening operations while simultaneously recording the process using the oscilloscope and ultra-high-speed camera. An analysis of a low-current vacuum arc in a residual helium gas environment, with a pressure of p = 1.00 × 101 Pa was carried out. Different phases of vacuum arc burning between electrodes in the discharge chamber were identified. In the stable phase, the arc voltage remained constant, while in the unstable phase, the arc voltage increased. The results of the time-lapse analysis were compared with the characteristics recorded by the oscilloscope, revealing a correlation between the increase in vacuum arc voltage and the intensity of flashes in the interelectrode space. The movement of microparticles ejected from the surface of the contacts—either reflecting or adhering to one of the electrodes—was observed. This analysis provides a deeper understanding of the processes involved in discharge formation and development under reduced pressure conditions. Understanding these mechanisms can support the design of vacuum interrupters, particularly in the selection of suitable contact materials and shapes.
Impact of Recycled Fine Aggregate on Physical and Mechanical Properties of Green Mortar
Authors: Wan Xiaoqi , Jia Zhiyou , Li Nannan , Luo Hua
Published: February 2025

Through research that combined green environmental protection with the resource usage of solid waste, we explored more possibilities for mortar using recycled fine aggregate (RFA) as a material. In this work, natural fine aggregate (NFA) with different proportions of RFA in mortar was produced, while maintaining the same particle size distribution. Four types of mortar were produced, with replacement ratios of 25%, 50%, 75%, and 100%, as well as a reference mortar type without RFA. A comprehensive evaluation of the mortar with different proportions was conducted, including its workability, density, capillary water absorption, compressive strength, and flexural strength. The results indicated that the compressive strength and flexural strength of mortar containing 50% RFA improve within 14 days. In addition, with increased RFA usage, the mortar’s mechanical properties decreased. The data obtained from this study will help in the application of RFA in green mortar.
Rare Earth Element Adsorption from Water Using Alkali-Activated Waste Fly Ash
Authors: Radojičić Tijana , Trivunac Katarina , Vukčević Marija , Maletić Marina , Palić Nataša , Janković-Častvan Ivona , Perić Grujić Aleksandra
Published: February 2025

As new technologies are developed, the demand for rare earth elements (REEs) has increased, despite limited awareness of their significant impact on people and the environment. In this study, waste fly ash was used as a precursor to synthesize inorganic aluminosilicate polymers by adding an activator to the alumina and silica compounds of the ash. Due to their structure and adsorption potential, their application for the removal of selected REEs (Gd3+, Y3+, and Sc3+) from water has been investigated. A decrease in the intensity of the quartz peak at 2θ of 26.6° in the XRD spectrum and the disappearance of the albite and mullite peaks due to dissolution during alkaline activation in both modified samples were observed. The appearance of a peaks at 2θ of 29.3° and 39.3° corresponding to calcite in the modified sample indicates the presence of wood ash. A shifting of the band in the DRIFT spectrum to 1030 cm−1 on the spectra of modified samples corresponds to the vibrations of Al-O and Si-O bonds and the formation of a polymeric network structure (Si-O-Si or Si-O-Al). According to pHPZC values, thermodynamic and kinetic parameters, and chemical composition, the presumed mechanism of REE adsorption is chemisorption and ion exchange. The highest adsorption efficiencies (up to 95%) for all examined REEs in both single and mixed REE solutions were obtained from an alkali-activated mixture of fly ash and wood ash. The results of this research are significant for expanding knowledge about the removal of REEs from the environment, the reduction of waste ash by their modification, and their potential subsequent use in construction as additives.
Towards Predicting Basketball Player Positions with Transformative Insights
Authors: Tsiannis Angelos , Efstathiades Christodoulos
Published: February 2025

Basketball players are traditionally classified into five positions. This study examines the correlation between player performance, game statistics, and designated positions. It also explores how statistical contributions have evolved over time. Machine learning classifiers were used to identify key metrics that distinguish player positions and determine the most effective classification algorithms. Our findings confirm a correlation between game statistics and positions, reinforcing the relevance of traditional roles. However, results also show that modern players contribute across multiple positions, reflecting a shift toward versatility. Despite this flexibility, players maintain distinct roles and responsibilities. This classification approach highlights key performance metrics and lays the groundwork for future clustering and mapping analysis, offering deeper insights into player roles and team dynamics in contemporary basketball.
Dynamic Adaptive Event-Triggered Mechanism for Fractional-Order Nonlinear Multi-Agent Systems with Actuator Saturation and External Disturbances: Application to Synchronous Generators
Authors: Narayanan G. , Baskar M. , Gokulakrishnan V. , Ahn Sangtae
Published: February 2025

This paper presents a novel dynamic adaptive event-triggered mechanism (DAETM) for addressing actuator saturation in leader–follower fractional-order nonlinear multi-agent networked systems (FONMANSs). By utilizing a sector-bounded condition approach and a convex hull representation technique, the proposed method effectively addresses the effects of actuator saturation. This results in less conservative linear matrix inequality (LMI) criteria, guaranteeing asymptotic consensus among agents within the FONMANS framework. The proposed sufficient conditions are computationally efficient, requiring only simple LMI solutions. The effectiveness of the approach is validated through practical applications, such as synchronous generators within a FONMANS framework, where it demonstrates superior performance and robustness. Additionally, comparative studies with Chua’s circuit system enhance the robustness and efficiency of control systems compared to existing techniques. These findings highlight the method’s potential for broad application across various multi-agent systems, particularly in scenarios with limited communication and actuator constraints. The proposed approach enhances system performance and provides a robust, adaptive control solution for dynamic and uncertain environments.
Singular-Value-Based Cluster Number Detection Method
Authors: Li Yating , Cai Jianghui , Yang Haifeng , Wang Jie , Shi Chenhui , Liang Bo , Zhao Xujun , Xun Yaling
Published: February 2025

The cluster number can directly affect the clustering effect and its application in real-world scenarios. Its determination is one of the key issues in cluster analysis. According to singular value decomposition (SVD), the characteristic directions of larger singular values likely represent the primary data patterns, trends, or structures corresponding to the main information. In clustering analysis, the main information and structure are likely related to the cluster structure itself. The number of larger singular values may correspond to the number of clusters, and their main information may correspond to different clusters. Based on this, a singular-value-based cluster number detection method is proposed. First, the transferred K-nearest neighbors (TKNN) density formula is proposed to address the limitation of the DPC algorithm in failing to identify centroids in sparse clusters of unbalanced datasets. Second, core data are selected by the DPC algorithm with a modified density formula to better capture the data distribution. Third, based on the selected core data, a sparse similarity matrix is constructed to further highlight the relationships between data and enhance the distribution of data features. Finally, SVD is performed on the sparse similarity matrix to obtain singular values, the cumulative contribution rate is introduced to determine the number of relatively large singular values (i.e., the cluster number). Experimental results show that our method is superior in determining the cluster number for datasets with complex shapes.
Predictive Factors of Cardiac Function Recovery and Mortality in Patients with Reduced Ejection Fraction Undergoing Transcatheter Aortic Valve Implantation
Authors: Güney Murat Can , Süygün Hakan , Polat Melike , Ayhan Hüseyin , Keleş Telat , Turinay Ertop Zeynep Şeyma , Karasu Betül Banu , Bozkurt Engin
Published: February 2025

Background and Objectives: Patients with reduced left ventricular ejection fraction (LVEF) are reported to have unfavorable outcomes following transcatheter aortic valve implantation (TAVI). This study aims to evaluate outcomes and identify predictive factors for LVEF recovery following TAVI in patients with reduced LVEF. Materials and Methods: This retrospective study analyzed 114 patients with symptomatic severe aortic stenosis (AS) with LVEF < 40% who underwent TAVI between 2011 and 2023 at two centers. Echocardiographic parameters, including LVEF, ventricular dimensions, and relative wall thickness (RWT), were assessed at baseline and during follow-up. The outcomes and predictors of substantial LVEF improvement and mortality were analyzed using univariate and multivariate logistic regression methods. Results: Anemia (OR = 4.345, 95% CI: 1.208–15.626, p = 0.024), RWT (OR = 1.224, 95% CI: 1.064–1.407, p = 0.005), and early post-procedural changes in left ventricular end-systolic dimension (LVESD) (OR = 1.297, 95% CI: 1.037–1.622, p = 0.023) and left ventricular end-diastolic dimension (LVEDD) (OR = 1.346, 95% CI: 1.034–1.753, p = 0.027) at one-month follow-up were identified as significant factors associated with LVEF recovery at one year. Regarding factors related to mortality, higher baseline AVMG levels were associated with a lower probability of death after one year (OR = 0.926, 95% CI: 0.875–0.979, p = 0.007). Conversely, a more limited increase in LVEF from baseline to the final follow-up was linked to poor prognosis and higher mortality at one year (95% CI: 1.045–1.594, p = 0.018). Conclusions: This study demonstrated that TAVI in patients with AS and reduced LVEF can be performed with high procedural success, low mortality, and significant improvement in cardiac function during follow-up. Additionally, anemia, baseline RWT, and early post-procedural changes in LVESD and LVEDD were identified as factors associated with LVEF recovery. Baseline AVMG and changes in LVEF at the final follow-up were found to be significant predictors of total mortality.
Clinical Significance of Sarcopenia Defined by the Cross-Sectional Area of the Masseter Muscle in Cerebrovascular Events: A Retrospective Cohort Study
Authors: Seğmen Fatih , Aydemir Semih , Kayan Temel , Biçer Firdevs Tuğba Bozkurt , Doğu Cihangir , Aktekin Esra Yakışık , Erdem Deniz , Ata Elif Uzun
Published: February 2025

Background and Objectives: This study aimed to investigate the clinical significance of sarcopenia, defined by the cross-sectional area of the masseter muscle (CSA-M), as an early marker for sarcopenia diagnosis and its association with mortality in patients with cerebrovascular events (CVE). Materials and Methods: In this retrospective cohort study, 120 patients aged 65 years or older with CVE admitted to Bilkent City Hospital between September 2020 and September 2023 were included. Patients with malignancy, prior CVE, or incomplete data were excluded. Parameters such as CSA-M measured via brain CT, Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA) scores, Nutritional Risk Score (NRS), duration of ICU and hospital stays, and 28-day mortality were evaluated. The CSA-M thresholds for sarcopenia were defined as <400 mm2 for men and <300 mm2 for women. Results: Sarcopenia prevalence was significantly associated with prolonged ICU (27.0 ± 33.1 days vs. 16.5 ± 22.4 days, p = 0.042) and hospital stays (34.8 ± 38.4 days vs. 21.3 ± 22.3 days, p = 0.017). Right and left CSA-M values were significantly lower in sarcopenic patients (p < 0.001). ROC analysis revealed CSA-M cut-off values of <300 mm2 (AUC = 0.82) for men and <295 mm2 (AUC = 0.83) for women as strong predictors of sarcopenia. Multivariate regression analysis showed a significant association between CSA-M and 28-day mortality (p < 0.05). Sarcopenia also correlated with lower albumin levels, a higher prevalence of ischemic stroke, and increased mechanical ventilation needs. Conclusions: CSA-M measured via brain CT is a reliable marker for sarcopenia and a predictor of clinical outcomes in CVE patients. Early identification and management of sarcopenia could improve patient prognosis. Further research is warranted to explore its potential in broader clinical contexts.
Torque Loss, Survival, and Strain Distribution of Implant-Supported Prostheses with Zirconia and Cobalt–Chromium Hybrid Abutments
Authors: Rodrigues Renata Cristina Silveira , Fiorin Lívia , Faria Adriana Cláudia Lapria , Bonfante Estevam Augusto , Ribeiro Ricardo Faria
Published: February 2025

Background and Objectives: The manufacturing of single crowns using hybrid abutments is an alternative that may be interesting in clinical practice, combining the advantages of the different materials used in a personalized design for each case. The purpose of this in vitro study was to evaluate the torque loss, survival, reliability, failure mode, and strain distribution of implant-supported prostheses with zirconia (Zir) and cobalt–chromium (Co-Cr) hybrid abutments. Materials and Methods: Abutments were milled by CAD/CAM and divided into two groups according to the materials used, Zir and Co-Cr, and cemented on titanium bases screwed to dental implants. Monolithic zirconia crowns were cemented on the abutments. The implant/abutment/crown sets were subjected to thermomechanical cycling (n = 10) (2 Hz, 140 N, 1 × 106 cycles, immersed in water at 5–55 °C) to evaluate the torque loss. The single load to fracture test (SLF) was performed to design the loading profiles (light, moderate, and aggressive) of the step-stress accelerated life testing (SSALT) (n = 21) to evaluate the survival and reliability. The representative fractured specimens were analyzed under optical and scanning electron microscopy. The digital image correlation (DIC) (n = 1) was performed using specimens embedded in polyurethane resin models that received static point loading, and the strain distribution was analyzed. Results: There was no difference in torque loss, survival, or reliability between zirconia and Co-Cr abutments. An analysis of the fractured surfaces showed that the abutments presented the same failure mode, where the fracture probably started in the titanium base/screw. The zirconia abutment model presented only compressive strains around the implant, while the Co-Cr abutment model showed tensile and compressive strains in the middle of the implant; however, all strains were within the clinically acceptable limits. There was a strain concentration in the titanium base close to the implant platform for both groups. Conclusions: Zirconia and Co-Cr hybrid abutments presented similar torque loss, survival, reliability, and failure modes, but the abutment material influenced the strain distribution around the implant. The titanium base screw was the weakest link in the system.
Environment-Oriented Assessment of Hybrid Methods for Separation of N-Propanol–Water Mixtures: Combination of Distillation and Hydrophilic Pervaporation Processes
Authors: Do Thi Huyen Trang , Toth Andras Jozsef
Published: February 2025

This study presents a novel approach to the dehydration of n-propanol using three hybrid methods—D + HPV, D + HPV + D, and D + HPV + D with heat integration—each combining distillation (D) and hydrophilic pervaporation (HPV) without the use of additional solvent agents, as in the most common separation method, extractive distillation. The optimization was performed using a ChemCAD process simulator, targeting 99.9 wt% purity for n-propanol and water. This is the first research to provide a comprehensive cost estimation and carbon footprint analysis for such configurations. Results show the D + HPV + D + HI method provides the best balance of energy efficiency, environmental sustainability, and economic feasibility. It reduced heat duties by 18.5% compared to D + HPV + D, achieved similar CO2 emissions to D + HPV with better energy efficiency, and lowered the total annual cost by 37.9% compared to D + HPV. The findings establish D + HPV + D + HI as a promising technology for sustainable and cost-effective n-propanol dehydration.
CO2 and O2 Separation Dual-Phase Membranes for Diesel Heavy-Duty Vehicles Applications
Authors: Zagoraiou Eirini , Cappai Luca , Moschovi Anastasia Maria , Mulas Gabriele , Yakoumis Iakovos
Published: February 2025

Diesel-engine Heavy-Duty Vehicle (HDV) exhaust gas mixture contains pollutants including unburned hydrocarbons, carbon monoxide, nitrogen oxides, and particulate matter. A catalyst-based emission control system is commonly used to eliminate the above pollutants. However, the excess of oxygen that exists in the exhaust gasses of diesel engines hinders the efficient and selective reduction of nitrogen oxides over conventional catalytic converters. The AdBlue® solution, which is currently used to eliminate nitrogen oxides, is based on ammonia. The latter is toxic in high concentrations. The aim of this work is to develop an Oxygen Reduction System (ORS) to remove oxygen from the exhaust gas of diesel engines, allowing the successful catalytic reduction of nitrogen oxides on a reduction catalyst without the need for ammonia. The ORS device consists of dense composite dual-phase membranes that allow the permeation of oxygen and carbon dioxide. Even though the oxygen concentration gradient across the membranes favors oxygen spontaneous diffusion from the atmosphere to the exhaust gas, the carbonate ion-based technology proposed herein utilizes the big difference in the concentration of carbon dioxide across the membrane to remove oxygen without any power consumption requirement. The results of this study are promising for the application of O2 reduction in diesel HDVs.
Endotoxin-Retentive Filters for the Online Preparation of Ultrapure Dialysis Fluid and Non-Pyrogenic Substitution Fluid: A Critical Review and Reference Guide
Authors: Catapano Gerardo , Morrone Giuseppe , Hu Lilio , Fragomeni Gionata , Buscaroli Andrea
Published: February 2025

Poor water treatments and concentrates to prepare dialysis fluids favor bacterial growth-producing pyrogens (e.g., endotoxins) that may cross hemodialysis, particularly high-flux, membranes. This puts hemodialysis patients at risk of acute bacteremia, pyrogenic reactions, long-term complications, loss of residual renal function, and poor nutritional status. Consequently, regulatory bodies worldwide recommend using ultrapure dialysis fluid for routine hemodialysis. Requests are also growing for the online production of sterile non-pyrogenic substitution fluid from ultrapure dialysis fluid. This way, large volumes of infusion solution may be safely and economically produced, enabling more end-stage kidney disease patients to benefit from the greater capacity of hemodiafiltration to remove toxins than purely diffusive hemodialysis treatment. Ultrapure dialysis and substitution fluids are often produced upstream from hemodialyzers by online filtration of standard dialysis fluid through cascades of bacteria- and endotoxin-retentive filters (ETRFs). Commercial ETRFs differ for membranes, operation, performance, duration and maintenance protocols, connection to a dialysis machine, disinfection procedures, and replacement schedule. Although suboptimal ETRF choice may increase treatment costs, the difficulty in gathering comparative information on commercial ETRFs complicates their selection. To aid dialysis centers in selecting the most convenient and suitable ETRF for their needs, herein, relevant characteristics of commercial ETRFs are reported and critically reviewed for a quick yet effective comparison.
Additive Manufacturing: Prospects and Diverse Applications
Authors: Li Zeyuan , Ruan Hulong , Li Minghao , Yu Chenglong , Jia Qixing , Wang Junjun , Chen Lina
Published: February 2025

Additive manufacturing (AM), also known as 3D printing, has emerged as a transformative technology in various industries, providing unprecedented design freedom and customized manufacturing solutions. This paper presents a detailed exploration of additive manufacturing applications in metallic materials, introducing the various types of additive manufacturing technologies, elucidating their fundamental principles, and summarizing current research endeavors. The manuscript offers insights into future directions and challenges in this rapidly evolving field, serving as a valuable resource for researchers and engineers aiming to harness the potential of additive manufacturing in advancing metallic materials.
Agronomic Efficiency of Compost Extracts and Nitrogen-Fixing Bacteria in Soybean Crops
Authors: Jesus Andressa Pereira de , Reis Mateus Neri Oliveira , Lourenço Lucas Loram , Mol Daniel José de Souza , Bessa Layara Alexandre , Brasil Marivaine da Silva , Vitorino Luciana Cristina
Published: February 2025

Regenerative agriculture and the use of bioinputs have been gaining prominence in the global agribusiness sector, driven by the growing demand for healthier foods produced with minimal impact on ecosystems. In this context, compost and its derivatives (compost extracts and teas) are used to provide effective microorganisms to crops, although production processes affect the efficiency of compost extracts, as well as the soil microbiota. Thus, the hypothesis raised was that the organic matter source used for compost formation affects the agronomic efficiency of compost extracts. The objective of this study was to evaluate the effect of compost extracts based on litterfall of angiosperm (AC) and gymnosperm (GC) species, and the use of inoculation with the nitrogen-fixing bacteria Bradyrhizobium japonicum and Azospirillum brasilense (Bra+Azo), on soil quality, crop growth, grain yield, and disease control in soybean (Glycine max L.) crops. Using AC and GC resulted in varying effects on soybean growth and soil microbial biomass carbon (SMBC), confirming the hypothesis that the organic matter source affects the agronomic efficiency of compost extracts. Plants inoculated with Bra+Azo exhibited higher chlorophyll contents, resulting in a higher photochemical yield than for those treated with compost extracts (AC and GC). However, plants inoculated with AC and GC exhibited high plasticity in mitigating photochemical stress, reaching similar photosynthetic and transpiration rates to those observed in plants inoculated with Bra+Azo. Additionally, inoculation with Bra+Azo, overall, improved the photosynthetic efficiency of soybean plants, and the compost extracts (AC and GC) were more effective than the inoculation with Bra+Azo in increasing soybean 1000-grain weight, probably due to improvements in root development. The growth promotion observed with AC and GC is likely attributed to increases in SMBC by these compounds, denoting improvements in soil quality and biocontrol of damage caused by insect attacks.
Anticancer Potential of Azatetracyclic Derivatives: In Vitro Screening and Selective Cytotoxicity of Azide and Monobrominated Compounds
Authors: Moldoveanu Costel , Mangalagiu Ionel I. , Zbancioc Gheorghita , Danac Ramona , Tataringa Gabriela , Zbancioc Ana Maria
Published: February 2025

This study investigated the antiproliferative activity of three classes of benzo[f]pyrrolo[1,2-a]quinoline azatetracyclic derivatives. All compounds were screened against 60 cancer cell lines at a single dose of 10 μM. When we compared the activity of the three classes of azatetracyclic derivatives (azide, monobrominated and dibrominated), we found that the dibrominated compounds were less active, while the azides were the most active molecules. Compounds 3b and 5a, showing the best growth inhibition profile of all the drugs evaluated, were selected for the second stage of a full five-dose testing. According to the results of the in vitro screening, compounds 3b and 5a exhibit good to moderate anticancer activity (in micromolar range) against all nine cancer sub-panels, with compound 5a being more selective than compound 3b. Both compounds presented better activity than phenstatin on T–47D breast cancer cells, with compound 3b also being more active on SK–MEL–28 melanoma cells, while compound 5a was more active than phenstatin on COLO 205 colon cancer cells. As for the probable mechanism of action, the benzoquinoline derivatives could act as PI5P4Kα and PI5P4Kβ inhibitors or topoisomerase II inhibitors.
Synthesis of ω-Methylsulfinyl- and ω-Methylsulfonylalkyl Glucosinolates
Authors: Mavratzotis Manolis , Cassel Stéphanie , De Nicola Gina Rosalinda , Montaut Sabine , Rollin Patrick
Published: February 2025

General pathways were devised to synthesize ω-methylsulfinyl- and ω-methylsulfonylalkyl glucosinolates, which represent an important class of structurally homogeneous plant specialized metabolites. The first approach was based on the selective S-oxidation of ω-methylsulfanyl analogs previously obtained in our laboratory, producing the corresponding sulfoxide or sulfone counterparts in moderate yields. In an alternative approach, previously prepared ω-nitroalkyl methylsulfide precursors were selectively oxidized either to sulfoxides or to sulfones. The key-thiofunctionalized hydroximoyl chloride intermediates were prepared in situ from sulfoxides or sulfones using a nitronate chlorination strategy. A coupling reaction with 1-thio-β-d-glucopyranose was directly applied, followed by O-sulfation of the intermediate thiohydroximates. The final deprotection of the sugar moiety produced the target compounds, including renowned glucoraphanin and homologs, intended for further bioactivity investigations.
Biologically Active Peptides from Corn Gluten Meal Improve Microbiota Disorders Caused by Helicobacter pylori Infection in Mice
Authors: Li Guanlong , Xie Yongchao , Wang Quanxin , Miao Zhengfei , Liu Xiaolan , Zheng Xiqun
Published: February 2025

This study investigated the potential effects of corn protein activity peptides (CPAPs) on inflammation response levels and gastrointestinal microbiota in Helicobacter pylori (H. pylori) infection mice. CPAPs significantly up-regulated the mRNA expression of the anti-inflammatory factor IL-10 and down-regulated the mRNA expression of the pro-inflammatory factors TGF-β, TLR4, MyD88, and NF-κB, indicating that CPAPs may antagonize H. pylori-induced inflammatory responses by inhibiting NF-κB signaling pathways. Through the intervention of CPAPs, H. pylori colonization in the stomach was significantly reduced. Additionally, the structural composition of the gastrointestinal microbiota improved, with an increase in abundance and diversity. These changes positively regulate gastrointestinal microbiota disorders in mice. In addition, the PICRUST function prediction of intestinal microbiota revealed that CPAPs may prevent or reduce metabolic disorders brought about by H. pylori, which improve biometabolic pathways by modulating intestinal microbiota composition. In conclusion, these findings suggest that CPAPs may prevent or mitigate metabolic disorders induced by H. pylori, offering theoretical support for the development of corn-protein-based functional foods.
Tocochromanols in the Leaves of Plants in the Hypericum and Clusia Genera
Authors: Mišina Inga , Lazdiņa Danija , Górnaś Paweł
Published: February 2025

Now under Clusiaceae and Hypericaceae, Clusia and Hypericum were previously categorized under one family until they were divided in 2003 by the APG III system. The Clusia genus is characterized by the presence of tocotrienol derivatives with antiangiogenic properties, and only Hypericum perforatum tocochromanol content has been studied in the Hypericum genus. Twelve species were analyzed: H. aegypticum, H. calycinum, H. empetrifolium, H. lancasteri, H. olympicum f. minus ‘Sulphureum’, H. perforatum, H. xylosteifolium, C. fluminensis, C. minor, C. odorata, C. palmicida, and C. tocuchensis. Plant leaves were analyzed for their tocochromanol (α-, β-, γ-, and δ-tocotrienol and tocopherol) contents using a reverse-phase high-performance liquid chromatography with fluorescent light detector (RP-HPLC-FLD) method. While α-tocopherol (α-T) was present in the highest proportion, the leaves had significant tocotrienol (T3) contents. Following α-T, δ-T3 was present in most Clusia samples, and γ-T3 in most Hypericum samples, except H. olympicum, in which α-T3 followed. C. minor had the highest α-T (112.72 mg 100 g−1) and total tocochromanol (141.43 mg 100 g−1) content, followed by C. palmicida (65.97 and 82.96 mg 100 g−1, respectively) and H. olympicum (α-T 32.08, α-T3 30.68, and total tocochromanols 89.06 mg 100 g−1). The Hypericum genus is a valuable source of tocotrienols, with potential use after purification.
Variability of Sialic Acids in Beef Breeds and Nutritional Implications in Red Meat
Authors: Contò Michela , Miarelli Maria , Di Giovanni Sabrina , Failla Sebastiana
Published: February 2025

This study examines the variability of sialic acids, specifically N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), in beef from seven cattle breeds (Holstein Friesian, Red Pied, Maremmana, Chianina, Charolais, Limousin, and Piemontese). Neu5Gc, a non-human sialic acid linked to inflammation and disease risk, showed significant breed differences (p < 0.001), with the highest concentration in Holstein Friesian (61.02 µg/g) and the lowest in Piemontese (20.87 µg/g). Neu5Ac, known for its neuroprotective properties, was most abundant in Piemontese (112.99 µg/g, p = 0.032) and lowest in Limousin (81.25 µg/g). The Neu5Ac/Neu5Gc ratio, critical for dietary health, exceeded the threshold of 5:1 only in Piemontese (5.49), identifying it as a breed with a higher ratio. This study highlights the influence of breed, with limited effects of muscle type and aging, on sialic acid content. Significant correlations were observed between Neu5Gc and fatty acid classes (p < 0.05) and between Neu5Ac and polar amino acid groups (p < 0.01). The findings support selective breeding to optimize beef’s nutritional profile, enhancing its health benefits for consumers.
Nanoimprinted Materials for Nanoparticle Sensing and Removal
Authors: Doveri Lavinia , Mahmood Azhar , Pallavicini Piersandro
Published: February 2025

The booming expansion of nanotechnology poses the problem of environmental pollution by nanoparticles (NPs). The available methods for sensing and removing NPs from the environment are typically lengthy and instrumentally demanding. The recent introduction of NP-imprinted polymers (NPIPs), either as films or bulk materials, is an important step toward the simple and fast sensing and removal of NPs from water and air. Similarly to the well-established molecularly imprinted polymers, in NPIPs, an organic or inorganic polymeric material is first obtained with embedded NPs. Then, the NPs are chemically or physically removed by acting as a template, i.e., leaving a polymeric matrix with cavities of the same shape and dimensions. After the first examples were published in 2014, the literature has so far reported an increasing number of NPIPs that are capable of reuptaking NPs from water (or, more rarely, air), with remarkable size and shape selectivity. By laying an NPIP layer on a reporter (typically an electrode), devices are obtained that are capable of sensing NPs. On the other hand, bulk NPIPs can reuptake massive amounts of NPs and have been used for the quantitative removal of NPs from water. This review begins with an overview of NP-imprinted hollow capsules, which can be considered the ancestors of NPIPs, both as conception and as preparative methods. Then, the literature on NPIPs is reviewed. Finally, the possible evolutions of NPIPs are highlighted from the perspective of stepping toward their real-life, field use.