bluuebunny/crossref_metadata_2025 huggingface dataset:
A PREVALENCE STUDY OF PULMONARY HYPERTENSION IN CKD PATIENTS ON MAINTENANCE HEMODIALYSIS
Authors: T Chakravarthi , P Nagarajan , S Manoharan , Kumar R. Aravind , R Kaaviya
Published: November 2024

Objective: Chronic kidney disease (CKD)-is an emerging public health problem. Cardiovascular disease is the most common cause of mortality in
CKD. Pulmonary hypertension (PH) is an overlooked cardiovascular complication of CKD, especially in end-stage renal disease (ESRD). PH is
defined as "a mean pulmonary artery pressure more than or equal to 25 mmHg at rest or 30 mmHg at exercise. This analytical cross- Methods:
sectional study was conducted in Department of Nephrology, Government Mohan Kumaramangalam Medical College and Hospital from April
2023 to March 2024. 108 patients of end stage renal disease (ESRD), on maintenance hemodialysis (HD); underwent Trans thoracic
Echocardiography were selected. Pulmonary hypertension was further divided into mild (PAP b/w 30-45mmHg), moderate (PAP b/w 45-
65mmHg) and severe pulmonary hypertension (PAP > 65mmHg). The effect of different vascular accesses, age, gender, dialysis vintage on the
development of pulmonary hypertension was observed. Out of 108 patients, 50 patients (54%) had pulmo Results: nary hypertension (PH);
30(60%) had moderate, 15(30%) had mild, and 5 (10%) patients had severe pulmonary hypertension (PH). Pulmonary hypertension was present in
45(50%) patients with AVF. Pulmonary hypertension was more common in females; present in 28 females (56%) and 22 males (44%), that was
statistically significant (p<0.05). Mean duration of hemodialysis in (months) of patients with PH was 36 ± 8 vs. 12 ±7 in patients without PH
(p<0.05). Age had no relation to development of PH. This study found a high prevalence (54%) of PH Conclusion: among dialysis patients.
Statistically significant association was observed between presence of malnourished patient, moderate LV dysfunction, presence of concentric
LVH and Pulmonary hypertension.
MECHANICAL THROMBECTOMY OF SMA- A CASE REPORT
Authors: Devi T Paulia , Manivannan Manivannan , Niruba Sindhu
Published: November 2024

Mesentric Ischemia occurs most commonly due to occlusion of superior mesentric vessels. Treatment options vary depending on the time of
presentation and the extent of disease. Here presenting a interesting case of SMA thrombosis in a 65 years female for which Mechanical
Thrombectomy was done.65 years female presented with Complete thrombosis of Superior mesentric artery with patchy gangrene of of a
segment of jejunum. We proceeded with Mechanical thrombectomy of SMA with resection of the segment of jejunum with Jejunostomy .Patient
started on Heparin postoperatively and also given both enteral and parenteral nutrition. She was discharged on postoperative day 30.Acute
thromboembolic occlusion of the superior mesentric artery is a condition with a serious prognosis. Despite considerable advances in medical
diagnosis and treatment, mesentric vascular occlusion still has a poor prognosis with a inhospitable mortality rate of 59 to 93%. Although the
prognosis of mesentric ischemia is poor, a prompt diagnosis, aggressive surgical treatment and supportive intensive care could improve the
outcome of this condition.
RAPID ANTIGEN DETECTION KIT AS A DIAGNOSTIC TOOL FOR SARS COV-2
Authors: Daivik Jigar , Jethva Mayur , Rohit Pooja
Published: November 2024

Background: The rst case of SARS CoV2 was detected in December 2019 from Wuhan city of China and in January 2020 from India. Since then,
COVID-19 disease was rapidly spread out to all over the world and presented as severe pandemic. Real time RT-PCR is the gold standard frontline
test for diagnosis of COVID-19 disease, caused by SARS-CoV-2 virus but it is time consuming and requires specialized laboratory facilities interms of equipment, biosafety & biosecurity. Material & Methods: This retrospective study was undertaken from duration of June 2020 to
October 2021 at B.J Medical college, Ahmedabad. In this study four rapid antigen detection test kits were evaluated for acceptance and fourteen
rapid Ag Detection kits were validated (batch validation) as per ICMR guidelines and compared with gold standard real-time RT-PCR test at BJMC
Ahmedabad. Considering real-time RT-PCR as the gold standard test, the sensitivity and specicity of the rapid antigen test kits were calculated.
Result: One out of four rapid Ag detection kits for evaluation, and all out of Fourteen in use approved rapid Ag detection kits for batch validation,
were showing sensitivity more than 50% and specicity 100% and fullled the acceptance criteria dened by ICMR. Conclusion: Though gold
standard test is real time PCR, rapid Ag tests help in early detection and containment of infection, allay the anxiety and fear of healthcare workers
and aid in better clinical management of the patients.
EXTENSION OF NEWLY DIAGNOSED OLFACTORY NEUROBLASTOMA: A RARE TUMOUR
Authors: Vinodbhai Patel Meet , Singh Gurudas , Meena Ram Singh , Peepre Karan Singh , Mittal Yash
Published: November 2024

Esthesioneuroblastoma, or olfactory neuroblastoma, is a rare malignant neoplasm of the sinonasal tract originating from the olfactory
neuroepithelium with neuroblastic differentiation. It most often presents in the superior nasal cavity. Since its initial description in 1924 by Berger
and Luc, there have been reports of more than 1000 cases of esthesioneuroblastoma worldwide. Esthesioneuroblastoma is a locally aggressive
neoplasm and metastasizes by both hematogenous and lymphatic routes.
PREDICTION OF PRETERM BIRTH ON THE BASIS OF COMPLETE MATERNAL HEMOGRAM-A PROSPECTIVE OBSERVATIONAL STUDY
Authors: S Inchara , T Chandrashekhar , Kantamneni Shamili , CU Nikhitha
Published: November 2024

Prematurity is dened as a birth that occurs before 37 completed weeks (less than 259 days) of gestation. It is associated considerable risk of
morbidity and mortality, particularly among extremely preterm infants. It complicates 5-8% of pregnancies in most developed and developing
countries and incidence is still increasing worldwide. This study was aimed to estimate the importance of complete blood count parameters like
neutrophils, neutrophil to lymphocyte parameters, platelet to lymphocyte parameters for predicting the timing of birth in threatened preterm labour
cases. This prospective observational study was conducted in Department of OBG, Vijayanagar Institute of Medical Sciences, Ballari, between
01st August 2023 to 31 st January 2024. Gestational week at delivery showed weak negative correlations with LMR (Lymphocyte- to-Monocyte
Ratio) (r* = -0.211, p = 0.03*) and CRP (C-Reactive Protein) (r* = -0.06, p = 0.56), indicating that higher LMR and lower CRP levels may be
associated with longer gestational periods. The correlations for WBC (White Blood Cell count) and NLR (Neutrophil-to- Lymphocyte Ratio) were
not signicant (NS). As a result, only WBC was found to be a valuable parameter in predicting preterm labor and PPROM, as the CBC test is a cheap
and routinely applied test. Although increased LMR levels were demonstrated to be associated with preterm birth and threatened preterm labor,
respectively, to be able to extrapolate these ndings into clinical daily practice, further studies are needed
STUDY OF PLATELET INDICES IN DIFFERENTIAL DIAGNOSIS OF THROMBOCYTOPENIA CASES IN TERTIARY CARE HOSPITAL, MAHARASHTRA, INDIA
Authors: Patil Swastika , Nesargi Aditya , Gogate Bageshri , Khandeparkar Siddhi G. Sinai
Published: November 2024

Background: Quantification of platelet indices in automated analyzers' has superiority over the manual estimation because it is quick, effortless
and cost-effective method which also eliminates the observer bias and artefactual problems of manual method. We studied four platelet parameters
i.e., MPV, PDW, LCR and PCT in cases of thrombocytopenia in order to interpret their importance, if any, behind the mechanism of low platelet
count Methods: An observational study was undertaken for a period of six months from September 2023 to February 2024 in the pathology
laboratory at Shrimati Kashibai Navale Medical College And General Hospital, Pune , Maharashtra using 6 part (SYSMEX 350) automated
hematology analyzer . Result: A total of 200 patients with thrombocytopenia (<1,50,000 / µL) were included in the study. There were 64% males
and 36% females in this study. In our study MPV & LCR increased as platelet count decreased . Thrombocytopenia cases were divided into two
groups , namely group A which included thrombocytopenia due to Hyper destructive cause while group B included thrombocytopenia due to
Impaired production of platelets. MPV, LCR, PCT and PDW platelet indices were higher Group Athan Group B Conclusion : Platelet parameters
like PDW, LCR,MPV and PCT can be used to interpret the mechanism behind the low platelet count. In our conclusion, any alterations in platelet
volume indices can give an initial hint about the possible mechanism of thrombocytopenia like hypo proliferative category and increased
peripheral destruction categories
EVALUATION OF CLINICO-RADIOLOGICAL AND FUNCTIONAL PROFILE OF PATIENTS SUFFERING FROM BRONCHIECTASIS ACCORDING TO FACED SCORE
Authors: Chalavarya Varsha , Gupta Rahul
Published: November 2024

Background: Bronchiectasis, a once-neglected disease, has secured increased recognition in the past decade, and yet does not have well established
and known disease severity scores. The severity assessment is required for appropriate treatment of the patients, stratication of the risk of
complications occurring, reduction of the costs associated with known disease. A combination of clinical, radiological, functional as well as
microbiological aspects can be used to assess severity of the disease. The present study was conducted Material and methods: from July 2022 to
January 2024 at Jaipur National University, Institute of Medical Sciences and Research Centre, Jaipur. It was a prospective study conducted on 100
cases, presenting with previously or newly diagnosed bronchiectasis. The study cases had a mean age o Results: f 53.7 ± 12.68 years, and the age group
of 46-60 years had the maximum number of individuals (34%), with females accounting for 51%. Smoking habit revealed 60% were smokers. Most
common clinical symptoms and signs were cough with expectoration (90%) and crepitation (100%), respectively. Most common grade of dyspnea
observed was 2 (40%). Haemophilus inuenza was the most prevalent organism (35%). Single lobe was involved in 32% of the patients. The most
common type of bronchiectasis was cystic (75%). The most common functional impairment was obstructive (50%). On evaluating the FACED score,
most of the cases were of moderate disease (48%), followed by mild (36%) and severe (16%) cases. In c Conclusion: onclusion, the results of our study
present the structure and corroboration of the FACED score, which is simple to use, interpret and elucidate in patients with non-cystic brosis
bronchiectasis, as well as being multidimensional, on regard of its conglomeration of different key aspects of the presented disease.
THE PSYCHOLOGICAL IMPACT OF POLYCYSTIC OVARY SYNDROME (PCOS) ON WOMEN: A CROSS-SECTIONAL STUDY
Authors: Chakravarty Upangona , Srivastava Pranshu
Published: November 2024

Polycystic Ovary Syndrome (PCOS) is one of the most prevalent endocrine disorders affecting women of reproductive age, and it significantly
influences both physical and psychological health. This study investigates the relationship between the cardinal symptoms of PCOS—irregular
menstrual cycles, hirsutism, acne, and alopecia—and psychological conditions such as depression and anxiety. Using a cross-sectional study
design and a self-administered questionnaire, data were collected from women diagnosed with PCOS. The results highlight the severe
psychological distress caused by PCOS, particularly related to body image and self-esteem issues. Furthermore, the study exposes the inadequate
mental health support available for women with PCOS. The findings emphasize the need for integrated healthcare approaches that address both the
physical and psychological aspects of PCOS.
PRO-OXIDANT AND ANTIOXIDANT STATUS AS A DIAGNOSTIC INDEX OF PREECLAMPSIA RISK
Authors: Bunga Jacob Joel , Polur Havilah , Kumar Sambu Naveen , Suman Putta , Prasad Kedam Durga , Bobbala Indumathi
Published: November 2024

Background: Preeclampsia still causes maternal death and morbidity. This condition pathogenesis involves oxidative stress. This study
hypothesizes that decreased antioxidant defense mechanisms may increase lipid peroxidation, notably malondialdehyde (MDA), and
preeclampsia risk. Biochemical changes in lipid peroxidation (MDA) and enzymatic antioxidants like S Aim: uperoxide Dismutase(SOD) and
Glutathione peroxidase (GPx) were investigated in normal and preeclampsia pregnant women. Of the 100 Materials and Methods: cases, 50
were healthy pregnant women and 50 were preeclampsia women who met the inclusion and exclusion criteria. Fasting venous blood samples were
taken during antepartum to evaluate serum MDA, plasma SOD, and GPx levels. The findings revealed a si Result: gnificant elevation in MDA
levels 326.13 ± 101.54 and 195.07 ± 20.06 , p< 0. 001 and decreased antioxidant enzymes SOD levels 84.65 (±) 11.72 and 7,691 (±) 1,046 and
GPX levels 133.60 (±) 10.03 and 10,310 (±) 1,592 (p<0.0001) respectively in the preeclampsia women compared to normal pregnant women.
Conclusion: In preeclampsia, increased MDA and reduced antioxidant activity indicate oxidative stress. The insufficient neutralisation of reactive
oxygen species by antioxidants causes preeclampsia-related oxidative damage and tissue destruction.
ASSESSING THE ACCEPTANCE OF FAMILY PLANNING METHODS AMONG GRAND MULTIPARAS: SOCIOECONOMIC INFLUENCES AND CONTRACEPTIVE CHOICES IN INDIAN WOMEN
Authors: Marie Joe Sandra , Karmali Deepa
Published: November 2024

Background: Grand multigravidas are a common group of Indian female population who are not adequately educated about the risks and possible
outcomes involved with their pregnancy and the modes of contraception available. Various socioeconomic factors surrounding their living are still
held responsible for the poor acceptance of family planning methods even in this era of advancements. Objectives: This study is aimed to assess the
acceptancy of various family planning methods chosen by grand multiparas and the various socio-economic factors related to it. Materials And
Methods: A hospital based cross sectional study was conducted at Goa Medical college in the department of Obstetrics and gynecology, for a
period of 4 months. All grand multigravidas who attended the center for obstetric care and family planning methods were included. Data was
collected from hospital records and records of antenatal visits. Results: Permanent female sterilization was chosen as a method of contraception by
22.5% of the study population. Majority (48.1%) however did not choose any contraceptive methods. Various probable reasons as gathered from
the couple included desire to bear male child in future, apprehension about intrauterine contraceptive devices and strong disagreement from spouse
and family for permanent sterilization methods. Conclusion: Grand multiparity is common in women from lower socioeconomic class. The
existing governmental policies on antenatal counselling on contraception needs to be emphasized and exercised more seriously. Couple should be
counselled regarding the possible complicated outcomes in multigravida and primary importance to be directed towards improving the health of
the mother.
TRANSLATION AND LINGUISTIC VALIDATION OF COMPOSITE AUTONOMIC SYMPTOM SCALE (COMPASS 31) IN HINDI
Authors: Metange Deepika , Dadani Fatima , Iyer Saraswati , Deo Medha
Published: November 2024

Objective: Assessing the functioning of the autonomic nervous system is important in the evaluation of common neurological disorders, including
polyneuropathy, diabetes, and Parkinson's disease. The COMPASS 31 is a self-assessment instrument investigating autonomic symptoms.
Reliable translations of the questionnaire shall facilitate the clinical and scientic exchange and cooperation between autonomic research groups in
different laboratories and in different countries. Materials and Methods: The study aimed to provide translation and linguistic validation of the
Hindi version of the Composite Autonomic Symptom Scale COMPASS 31. The research was conducted in two stages. Phase 1 consisted of the
translation of the English version of the Composite Autonomic Symptom Scale COMPASS 31 into the Hindi version. The second phase consisted
of eld testing of the translated version to check test-retest reliability and validity. Phase 1 of this study was carried out as per the guidelines laid
down by the American Academy of Orthopedic Surgeons (AAOS). Results: Test–retest reliability was assessed correlating the total score and
domain scores derived from the English and Hindi versions of COMPASS 31 using Spearman correlations A positive correlation for the overall
score between English and Hindi versions (r = 0.98, P<0.001); a positive correlation was found also for individual domain scores. There was an
overall excellent internal consistency (alpha value > 0.9). There was an overall almost perfect agreement (single measures value >0.8) with a
statistically highly signicant p value (p <0.01). Conclusion: In summary, this study contributes a translated Hindi version of the COMPASS 31
that is reliable, highly internally consistent, and provides results identical to those of the original US English version.
EDITORIAL: THE LARGEST CHANDIPURA VIRUS OUTBREAK IN TWO DECADES—A CALL FOR HEIGHTENED VIGILANCE
Authors: Kumar Singh Rajesh , Singh Deo Rohit , Sara Shibu Agnes
Published: November 2024

Chandipura Virus Outbreak: APublic Health Challenge In India
The continuing Chandipura Virus (CHPV) outbreak in India, regarded
the greatest in the previous 20 years, is imposing enormous strain on
the country's public health system. Between June and mid-August
2024, India recorded 245 instances of acute encephalitis syndrome
(AES), 64 of which were proven to be related to CHPV infection.
Tragically, this outbreak has taken 82 lives, with a case fatality rate
(CFR) of 33%, predominantly affecting youngsters under the age of
fteen. Despite combined efforts by the World Health Organization
(WHO) and the Indian Ministry of Health and Family Welfare to
prevent the virus's transmission, further expansion is possible,
especially with the monsoon season bringing favorable circumstances
for vector populations[1].
DILEMMAS IN MANAGEMENT OF POSTPARTUM OVARIAN VEIN THROMBOSISA REVIEW
Authors: H. Rangwala Tasneem , Al Hubaishi Laila Y. , Rayan Ali Ahmed
Published: November 2024

Ovarian vein thrombosis is a rare condition that occurs within few days postpartum, affecting 1 in 500 to 1 in 2000 women. Predisposing factors
include pregnancy, surgical delivery, malignancies, pelvic infections and prothrombotic states, but in 16% cases it can be idiopathic. The common
presenting symptoms are abdominal pain, tenderness, fever and sometimes a palpable abdominal mass. Complications of symptomatic Ovarian
vein thrombosis can be fatal. Treatment with short duration of anticoagulation and antibiotics leads to a favorable outcome. In 30% cases it is
asymptomatic and detected incidentally on imaging studies. The aim of our review is to highlight the fact that clinicians should maintain a high
index of suspicion for this condition in postpartum women and differentiate symptomatic Ovarian vein thrombosis from benign, incidental
condition in order to institute timely and appropriate management. A ow chart to aid clinicians in the management of postpartum Ovarian vein
Thrombosis is presented.
ESTIMATION AND COMPARISON OF DEFLOURIDATION OF FLOURIDATED GROUND WATER USING FOUR NATURAL ADSORBENTS: MULTANI MITTI, CHALK POWDER, ORANGE PEEL POWDER AND RAGI POWDER
Authors: Saini Sushant , Gupta Kamal Kishor
Published: November 2024

This study highlights the global issue of uoride contamination in drinking water, affecting
approximately 260 million people in 30 countries, with India facing signicant challenges as endemic
uorosis impacts around one million individuals across 17 states. The elevated uoride levels are primarily attributed to
uoride-bearing minerals in local rocks and soils. The World Health Organization recommends maintaining uoride
concentrations near 1 mg/L to balance dental health benets while preventing uorosis. In response, various deuoridation
methods—such as precipitation and adsorption—are implemented in India to adjust uoride levels to optimal ranges. Given the
essential role of water in physiological processes for humans, animals, and plants, understanding the variable quality of
surface and groundwater is crucial. This variability is inuenced by local geological factors and the presence of contaminants,
necessitating effective management strategies for safe drinking water access.
A CASE REPORT: RADIAL SHORTENING OSTEOTOMY FOR GRADE II KIENBOCK'S DISEASE IN AN ATHLETE.
Authors: Angachekar Dhruva , Ponde Saurabh , Singh Samarth , Singh Ashish , Sirsat Prashik
Published: November 2024

Introduction: Progressive avascular osteonecrosis of the lunate is the described as Kienböck's disease. The common signs are a unilateral decrease
in wrist motion with concomitant discomfort and edema. The decision of surgery for symptomatic Kienböck's disease is mostly determined by the
preferences of the patient and the surgeon, as well as radiological parameters such as disease stage and ulna variation. For Kienböck's disease,
radial shortening osteotomy is a commonly used treatment that doesn't cause secondary alterations in carpal alignment or radiocarpal osteoarthritis.
Case Report: A 21-year-old male presented to our OPD with pain and restriction of movements in the left wrist. Clinical examination was
suggestive of tenderness over the lunate and restriction of terminal wrist motion. Radiographs were suggestive of ulnar negative variance and distal
radio ulnar joint widening. Conservative management with NSAIDS was unsuccessful and we did an MRI of the left wrist joint. Report was
suggestive of Keinbock's disease. We performed a radial shortening osteotomy and the patient had good post operative recovery and clinical
results. Radial shortening osteotomy provides good clinical outcomes in patients of Keienbocks dise Conclusion: ase with an ulnar negative
variance pattern. Good long term functional outcomes are seen with this procedure.
SUCCESSFUL MANAGEMENT OF ACUTE METHEMOGLOBINEMIA DUE TO NITROBENZENE POISONING IN A TERTIARY CARE HOSPITAL: A CASE SERIES
Authors: Blessy Lois Ts E Joy , Kumar K Dinesh , Babu S Prakash , Simha Reddy A. Krishna
Published: November 2024

Introduction: Nitrobenzene poisoning, although an uncommon method of suicidal poisoning, can lead to life-threatening complications. The
incidence is on the rise due to easy access to products containing nitrobenzene. Clinical presentation of acute methemoglobinemia can range from
mild to severe symptoms and signs with rapid progression to grave outcomes. 17-year-old male: Sever Case Series: e abdominal pain, vomiting,
dizziness. The patient is managed with methylene blue, ascorbic acid, mechanical ventilation, Hemodialysis, antibiotics, and PRBC transfusion.
Outcome: Extubated and discharged. 1. 22-year-old male: Vomiting, blurred vision after ingesting “Bloom ower” compound. We managed with
methylene blue, ascorbic acid, and FAD. Discharged against medical advice. 2. 33-year-old male: Unco Outcome: nsciousness, vomiting after
ingesting “Flower Bloom Plus” (30% nitrobenzene). We managed with methylene blue, antibiotics, riboavin, mechanical ventilation, and
exchange transfusion. Outcome: Extubated and discharged. 3. 65-year-old patient: Loose stools, decreased sensorium after ingesting unknown
insecticide. We managed with methylene blue, exchange transfusions, antibiotics, and mechanical ventilation. Outcome: Extubated and
discharged. Conclusion : Timely identication, diagnosis, and treatment with the antidote methylene blue, exchange transfusion, along other
supportive care have been proven to save lives.
ACUTE PANCREATITIS AS A COMPLICATION OF SCRUB TYPHUS: A RARE CASE REPORT
Authors: Farswal Anuj , Mittal Yash , Manglani Ravi K , Upadhaya Sunil Dutt
Published: November 2024

Scrub typhus, a rickettsial infection, is widespread across much of India and can lead to multi-organ failure and death. Scrub typhus is transmitted
through the bite of chigger larvae, specifically Leptotrombidium deliense, and is caused by the bacterium Orientia tsutsugamushi. Common
clinical features include fever, headache, lymphadenopathy, and the characteristic black eschar. Acute pancreatitis, though extremely rare, is a
serious and potentially fatal complication of the disease. Here, we discuss a case report of a 25-year-old adult male who developed acute renal
failure, pancreatitis, and severe sepsis due to scrub typhus. This case underscores the importance of recognizing and addressing rare complications
of common tropical infections to ensure the best possible outcomes
CUTANEOUS ADVERSE DRUG REACTIONS: CLINICAL PATTERN AND CAUSATIVE AGENTS IN A TERTIARY CARE CENTRE IN CENTRAL KARNATAKA
Authors: B. Patil Aditi , Rajashekhar Nadiga , A Sushma
Published: November 2024

Introduction: Cutaneous adverse drug reactions (CADRs) are the most common manifestations of drug sensitivity, exhibiting a wide range of
morphologies. Thus, understanding these reactions is crucial for accurate diagnosis and prevention. Objective: The objective of the study was to
study the most common aetiology, various clinical manifestations of adverse cutaneous drug reactions (CADR), and to assess the association of
morphological cutaneous pattern of CADR and etiological group of drugs. A cross-sectional, observati Methods: onal study was carried out at
dermatological department of a tertiary care center in Cental Karnataka. Written informed consent was obtained from all patients, and data were
gathered using a pre-tested Performa that included a comprehensive clinical history, examination, and pertinent laboratory investigations. The
results were analyzed using SPSS (Version 21.0). This study included a total of 72 patients out of w Results: hich 43 were females and 29 were
males. Maximum CADR were observed in the age group of 20-30 years (31.9%), followed by 31-40 years (25.0%). The most common etiological
group of drugs responsible for CADRs is antibiotics (33.3%) pointing toward its rampant use with and without prescription, NSAIDs (19.4%),
antiepileptics (18.05%), and antitubercular therapy (5.55%) followed by antiretroviral therapy, antiprotozoals and antifungal agents (4.16% each).
Majority of CADRs, that is, 52.7% comprised of probable CADRs as per “Naranjo's algorithm.” The most common type of lesions observed were
papules (30%), macules (20%), plaques (7%), and edema (7%). The signicance of this study was to st Conclusion: udy the prole of CADR and
to highlight the need for heightened vigilance among healthcare providers in monitoring and promptly reporting such reactions. Effective
documentation and systematic oversight of adverse drug reactions (ADRs) can signicantly reduce adverse events in patient care and contribute to
more effective drug administration. Further research is crucial to enhance awareness of potential CADRs and to facilitate early detection,
ultimately supporting the implementation of robust drug safety protocols.
RAPIDLY PROGRESSIVE ATYPICAL AGGRESSIVE VERTEBRAL HEMANGIOMA: A CASE REPORT
Authors: Singh Chauhan Lokendra , Shreyas C S , Suthar Lakshit , Singh Tak Mahendra
Published: November 2024

Vertebral hemangiomas are relatively common vascular neoplasm of endothelial cell. It is asymptomatic and often present as incidental nding.
Surgery is recommended for aggressive vertebral hemangiomas if symptoms are severe or there is involvement of any neural structures. A 40-yearold female patient was admitted to our department with complain of severe back pain. Series of radiological investigation like X-ray CT Scan, MRI
were suggestive of vertebral hemagioma at D11 level with involvement of posterior elements and extension into the epidural space with spinal cord
compression. The patient treated surgically with intraoperative vertebroplasty with posterior spine xation from D-9 to L-1 level. Histological
examination conrmed the diagnosis of atypical hemangioma, specically an epithelioid hemangioendothelioma.
PUPIL EXPANSION DEVICE-A BOON IN SMALL PUPIL CATARACT SURGERY
Authors: Premanandan Reshma , Bubanale Shivanand C. , B. K. Bhagyajyothi , B. Patil Shivanand , Manjunath Naik Keerti
Published: November 2024

Context: Cataract is the leading cause of moderate or severe vision impairment globally. The small, poorly dilated pupil is one of the most common
difficulties faced by cataract surgeons. This study emphasises on the efficacy & safety of pupil expande Aims: rs on small pupil in a
phacoemulsification cataract surgery. This prospective interventional non comparative study. This Settings and Design: Methods and Material:
prospective interventional non comparative study was approved by the local institutional ethical committee & written informed consent was
obtained from 48 patients with small pupil of < 5mm & undergoing cataract surgery during the period of August 2023 to July 2024. The Results:
mean patient age was 66.54 ± 9.22 years. The B HEX PED was successfully applied in all eyes. On Post operative day 1 the mean pupil diameter
was 4.78 ± 0.44 mmHg and postoperative day 28 it was 3.55 ± 0.43 mmHg. 62.5% of cases had round pupil postoperatively on day 28. Major
complication noted with PEDs was corneal edema in 35.42 % followed by iris bleeding and floppy iris while 52.08% had no complications. There
was no significant difference in IOP on POD 1 and POD 28 compared to pre operative IOP. Small pupil is Conclusions: of the most important
causes of intraoperative complications during cataract surgery. The PEDs safely and effectively provided and maintained adequate pupil expansion
and surgical visualization in eyes with significantly reduced the chance of complications and increased the success rate of small pupil cataract
surgery.
MANEJO DA HIPERTENSÃO INTRACRANIANA EM PACIENTES NEUROCRÍTICOS – ABORDAGENS E TECNOLOGIAS PARA O CONTROLE DA PRESSÃO INTRACRANIANA EM TRAUMAS E HEMORRAGIAS CEREBRAIS
Authors: Melissa Garcia Silva Saut  , Aliandro Willy Duarte Magalhães  , Jaqueline Maria Lima Gerbase  , Letícia Borin Alves  , Cleber Santos Barbosa  , Thalita de Cássia Silva de Oliveira  , Aneci Calixto da Rocha Barbosa  , Gizele Pani  , Vivian Trevisan de Castro  , Tamires Santos Rios  , Rodrigo Silva De Paula
Published: November 2024

A hipertensão intracraniana (HIC) é uma complicação frequente em pacientes neurocríticos, especialmente em casos de traumas cranioencefálicos (TCE) e hemorragias cerebrais. A falha no controle da pressão intracraniana (PIC) pode resultar em isquemia cerebral, herniação e morte. Este artigo revisa as abordagens mais recentes para o manejo da HIC, destacando intervenções cirúrgicas, como a craniectomia descompressiva, e o uso de tecnologias avançadas, incluindo monitoramento invasivo e técnicas de neuroimagem. Além disso, são discutidas as terapias farmacológicas, como a osmoterapia, e as estratégias emergentes, como o uso de neuroprotetores e novos parâmetros para a monitoração da PIC. A revisão da literatura revela que uma abordagem integrada e o avanço das tecnologias não invasivas estão revolucionando o manejo da HIC, mas barreiras como o acesso desigual a tecnologias de ponta e a necessidade de mais pesquisas clínicas limitam a aplicação generalizada dessas inovações.
APENDICITE AGUDA: UM ESTUDO SOBRE OS AVANÇOS DA CIRURGIA ROBÓTICA NO MANEJO DESSA CONDIÇÃO
Authors: Oliveira Lucas , Espino Ferrari Cristina Maria , Marques Chiamulera Thainara , Marques Chiamulera Maria Luiza , Carneiro Raguzzoni Piclum Isadora
Published: November 2024

A apendicite aguda é uma das condições cirúrgicas mais comuns em todo o mundo, afetando milhões de pessoas anualmente. Esta patologia, caracterizada pela inflamação do apêndice vermiforme, geralmente se manifesta de maneira súbita e exige intervenção cirúrgica urgente para evitar complicações graves, como a peritonite e o choque séptico. A evolução das técnicas cirúrgicas, especialmente com a introdução da cirurgia robótica, tem transformado o manejo de diversas condições, incluindo a apendicite aguda. A cirurgia robótica oferece vantagens como maior precisão, menor trauma tecidual, recuperação mais rápida e redução das complicações relacionadas à incisão convencional, como infecções e aderências. Trata-se de uma revisão sistemática da literatura, a qual investigou sobre o uso da cirurgia robótica no manejo da apendicite aguda, para avaliar a eficácia terapêutica, pela coleta de dados nas plataformas PubMed, LILACS, Periódicos CAPES, EMBASE e Scielo, dos últimos 5 anos. Assim,  os estudos revisados fornecem uma visão abrangente sobre a comparação entre as técnicas de apendicectomia laparoscópica (AL) e assistida por robô (AR), destacando as vantagens e limitações de cada abordagem. A apendicectomia robótica, embora ofereça benefícios notáveis em termos de precisão, visualização e destreza cirúrgica, especialmente em casos mais desafiadores e em cenários de difícil acesso, enfrenta restrições significativas devido ao seu elevado custo e à necessidade de treinamento especializado. Esses fatores limitam sua adoção generalizada, particularmente em sistemas de saúde com recursos financeiros limitados.
EFEITOS DA TERAPIA MANUAL NO TRATAMENTO DE PACIENTES COM ESPONDILOLISTESE
Authors: Caymmi de Albuquerque Laurindo Ashley , Amorim Araujo Jaine , Maria Araújo de Abreu Talita , Vitória Rodrigues de Lima Freire Ellen , Clemente do Rêgo Gabriella , Adson da Cunha Medeiros Pedro , De Lima Silva Adriely , Martins de Lima Felipe , Castor Brito Vicente , Ramalho dos Santos Catarina , Gomes Costa Rita de Cássia , Valéria Chaves Lúcia
Published: November 2024

Este artigo tem como objetivo realizar uma revisão da literatura médica atual sobre a relação entre qualidade de vida e satisfação em usuários de próteses totais mucossuportadas e próteses totais implantossuportadas. Os índices Google Acadêmico, Scopus e Web of Science foram utilizados como mecanismos de busca para a seleção dos artigos, utilizando as palavras-chave “Qualidade de vida, Satisfação, Prótese totais mucossuportadas, Prótese totais implantossuportadas”. Conclui-se que usuários de próteses totais implantossuportadas apresentam melhor qualidade de vida e satisfação com suas próteses, quando comparados aos usuários de próteses totais mucossuportadas.
Cistos ovarianos e outras massas ovarianas benignas: Mecanismos de desenvolvimento, opções de diagnóstico e estratégias de manejo clínico
Authors: Bellorio Claudia Moreno Secco Hellmeister , Campos Karen Cinara Miranda Pinheiro de , Seidl Isabele , França Eva Hellen Celestino , Oliveira Wallace Alexandre , Bitar Júlia Souza , Zanellato Julia Mariot , Frota Bianca Maria Moreira , Mesquita Maria Ávila Nobre , Gotardo Eduardo , Rodrigues Rafaela Camacho , Souza Nayra Lurian Nascimento de , Carvalho Jaqueline Bianca de Andrade , Benigno Nathilla dos Santos , Amorim Bruna Leticia Matos , Filho Josué Fernandes Barbosa , Júnior Tarcísio Pereira da Rocha
Published: November 2024

Os cistos ovarianos e outras massas ovarianas benignas são condições comuns que afetam muitas mulheres em idade reprodutiva. Essas formações podem variar em tamanho, tipo e sintomatologia, sendo frequentemente assintomáticas ou apresentando sintomas como dor pélvica, alterações menstruais e sensação de peso abdominal. Embora a maioria seja benigna e regrida espontaneamente, algumas podem necessitar de acompanhamento ou tratamento, especialmente quando causam complicações. O diagnóstico preciso, por meio de exames clínicos e de imagem, é crucial para diferenciar essas condições de possíveis formas malignas, garantindo um manejo adequado e minimizando riscos à saúde da paciente. Essa revisão de literatura foi realizada por meio de publicações científicas encontradas nos seguintes bancos de dados: Biblioteca Virtual de Saúde (BVS), Public Medline (PubMed), Portal de Periódicos CAPES e Scientific Electronic Library Online (SciELO), sem restrição de período. Foram também consultados os sites oficiais do Ministério da Saúde e a literatura cinzenta. Em conclusão, os cistos ovarianos e outras massas ovarianas benignas são condições frequentes e, em sua maioria, de baixo risco. Muitas vezes assintomáticos, esses problemas podem ser tratados com monitoramento ou intervenção cirúrgica, conforme necessário. O diagnóstico precoce, por meio de exames clínicos e de imagem, é fundamental para garantir o manejo adequado e prevenir complicações. Embora a maioria dessas formações seja benigna, é essencial observar os sintomas e realizar o acompanhamento contínuo, considerando sempre a saúde e os desejos reprodutivos da paciente. A abordagem terapêutica deve ser personalizada, visando a qualidade de vida e a preservação da fertilidade.
Atuação Do Farmacêutico Hospitalar No Tratamento Quimioterápico
Authors: De Souza Holanda Gabriel Vinicius , Santos Viviane Marinho dos
Published: November 2024

Este artigo tem por objetivo realizar uma varredura da literatura médica vigente sobre as responsabilidades do farmacêutico hospitalar no tratamento de pacientes com câncer. Foram utilizados como motores de busca os indexadores Scientific Electronic Library Online – SciELO; PubMed; BVS, Medline e Lilacs para seleção dos artigos, através dos unitermos “Farmacêutico, hospitalar e quimioterapia’’. Conclui-se que o farmacêutico oferece orientações claras e acessíveis sobre como proceder durante o tratamento, explicando os efeitos dos medicamentos, as medidas preventivas e os cuidados domiciliares necessários. Essa atuação educativa não só empodera o paciente, mas também melhora a comunicação entre a equipe de saúde e a família, tornando o tratamento mais humano e menos traumático.
Design and Optimization of Energy-Efficient HVAC Systems for Smart Buildings
Authors: Mannan Rana
Published: November 2024

Heating, ventilation, and air conditioning (HVAC) systems are major contributors to building energy consumption, and their attention has been drawn to them by the growing need for energy-efficient solutions in contemporary architecture. HVAC systems are essential for ensuring comfort and reducing energy consumption in smart buildings. Incorporating energy-efficient HVAC systems into smart buildings contributes to sustainability and is consistent with international efforts to lower carbon emissions. The design and optimization of these systems are the subject of this study, which also looks at the fundamentals, background, advantages, drawbacks, and research gaps.
STRENGTHENING 21ST CENTURY SKILLS THROUGH AN INDEPENDENT CURRICULUM IN MATHEMATICS EDUCATION IN INDONESIA: CHALLENGES, POTENTIAL, AND STRATEGIES
Authors: MASJUDIN Masjudin
Published: November 2024

Several research results show that 21st century skills such as critical, creative, collaborative and communicative thinking in Indonesian students are not as expected. Then the Ministry of Education and Culture launched the Independent Curriculum as an effort to improve the quality of education and adapt it to the needs of the times. The aim of this research is to identify the challenges, potential and strategies for implementing the Independent Curriculum in strengthening 21st century skills in mathematics education in Indonesia. This research is a Systematic Literature Review (SLR) which examines various literature sources. The research results show that the Merdeka Curriculum has great potential in supporting the development of 21st century skills. The Merdeka Curriculum provides flexibility in learning, encourages creativity and critical thinking through a student-centred approach, and strengthens collaboration and communication skills. However, implementation faces challenges such as lack of resources, teacher preparedness, resistance to change, and the need for more flexible evaluation. The Merdeka Curriculum requires an implementation strategy that includes teacher training, development of innovative materials, technology integration, and ongoing evaluation
THE ROLE OF THE DRIVING TEACHER IN THE FREE CURRICULUM OF THE FREE ERA OF LEARNING
Authors: Patiung Amos , Lasmawan I Wayan , Suharta I Gusti Putu
Published: November 2024

This research aims to explore the role of mobilizing teachers in the implementation of Merdeka Curriculum in Indonesia. The research method used is a literature review, in which various journal articles, books and related documents from several periods are systematically analyzed. The results show that the role of the driving teacher has a significant impact on the transformation of education towards the Merdeka Curriculum. The driving teacher not only acts as a teacher, but also as a learning facilitator who encourages students to be active, critical, and independent in the learning process. They also play a role in creating a learning environment that is inclusive, student-centered, and relevant to individual needs. In addition, teacher advocates also play an important role in integrating relevant learning technologies and media to enhance learning effectiveness. Adequate digital skills are key in optimally utilizing technological resources. This research also highlights the importance of the role of mobilizing teachers in realizing the vision of Merdeka Curriculum which is more inclusive, responsive, and relevant to students' needs. In conclusion, developing the role of mobilizing teachers is key in improving the quality of education and preparing future generations to face the challenges.
On Absolute Tribonacci Series Spaces and Some Matrix Operators
Authors: Gökçe Fadime
Published: November 2024

In this article, the absolute Tribonacci space $\left|T_\theta\right|_{q}$ is introduced as the domain of the Tribonacci matrix on $\ell_q$. First, certain algebraic and topological structures such as $BK-$space, isomorphism, duals, and Schauder basis are studied. Then, some characterizations of compact and matrix operators on this space are given their norms, and Hausdorff
measures of noncompactness are determined.
Relaciones entre currículo y prácticas docentes. A propósito de los géneros de estudio y su enseñanza en Lengua y Literatura en nivel secundario
Authors: Tapia Stella Maris
Published: November 2024

En la escuela secundaria se enseñan géneros discursivos y saberes textuales y lingüísticos propios de la transmisión del conocimiento que, aunque conciernen a diversas disciplinas escolares, reciben un tratamiento específico en Lengua y Literatura. Se espera que estos saberes vinculados con la explicación, transmisión y apropiación de conocimientos propicien el desarrollo de habilidades de lectura y comprensión. El objetivo de este trabajo es problematizar tales saberes como géneros de estudio y/o como textos expositivos en clases de Lengua y Literatura en el ciclo básico de nivel secundario, provincia de Río Negro, Argentina, en una investigación cualitativa sobre las transformaciones de los objetos de enseñanza. Se analizan el diseño curricular de la Escuela Secundaria Rionegrina (ESRN) en comparación con los Núcleos de Aprendizajes Prioritarios (NAP). Se analizan, también, dos manuales de amplia circulación en las escuelas y clases y voces de docentes. Entre los géneros de estudio y los esquemas prototípicos abstractos como los textos expositivos se observan indistinciones teóricas que dan cuenta de un nudo epistemológico y un problema didáctico en la disciplina escolar.
Exploring the Needs and Challenges in Teaching English Grammar Communicatively in Albanian Context
Authors: Koca Suela , Benita Stavre  , Lindita Kacani
Published: November 2024

The aim of this study is to explore through details of teaching English grammar communicatively within the Albanian context. With the global trend for communicative language teaching, Albanian teachers of English as a foreign language face specific challenges in attempting to integrate this approach effectively in their classes. The research applies a mixed-methods approach, including a questionnaire and structured interviews with teachers from several districts in Albania. Both cases intend to assess the actual situation of teaching grammar of English as a Foreign Language, identify main obstacles, and highlight opportunities for integrating communicative grammar. Findings indicate that even though the teachers are aware of the theoretical aspects of communicative methods, sometimes they find it hard to implement them due to limited resources, insufficient teacher training, and traditional teaching curricula. Additionally, the study emphasizes the need for professional development programs and appropriate classroom materials that align with the communicative approach. By addressing these challenges, the research aims to provide concrete recommendations for teachers and policymakers to improve English grammar teaching in Albanian schools, so as to improve language proficiency and communicative competence among learners of different ages and educational levels in a larger context.
The Impact of Artificial Intelligence on Accounting and Finance in the Digital Economy
Authors: Tsiklauri-Shengelia Zhuzhuna
Published: November 2024

The artificial intelligence(AI) revolution and its impact on accounting and financial activities are positively evaluated; The focus is on new skills and capabilities needed by employees. It is concluded that artificial intelligence has the potential to transform the economy in many ways, but there are also significant threats and risks in terms of job displacement, inequality and international competition. AI's full potential will only be realized when policymakers, industry leaders, and the society will work together to create an ethical and fair framework for the development and use of AI. With such interdisciplinary collaborations and approaches (sharing the experiences of economists, technologists, ethicists and policy makers), it is possible that artificial intelligence will bring great benefits to everyone and significantly improve economic growth, development and prosperity.
Keywords: Artificial Intelligence(AI), accounting, consulting services, digital environment and economy.
Application of Artificial Intelligence in the Securities Market
Authors: Turmanidze Giorgi
Published: November 2024

Artificial Intelligence (AI) involves creating machines that replicate human cognitive functions, enabling them to think and act similarly to people. In the context of stock trading, AI refers to the use of technology designed to buy and sell shares with increased precision and efficiency compared to human capabilities. AI-driven systems are currently employed to predict stock market trends and analyze trading patterns among investors and brokers. Prominent financial institutions on Wall Street, such as Goldman Sachs and Morgan Stanley, are increasingly adopting specialized AI solutions, including data mining, natural language processing, and self-learning algorithms. These tools operate with greater speed than everyday applications. Additionally, AI aids wealth management firms in continuously monitoring market movements and adjusting portfolios to achieve target profits. While AI can significantly reduce workload and provide real-time recommendations, it does not entirely eliminate the need for human oversight.
Keywords: artificial intelligence, securities, trading, forecasting.