bluuebunny/crossref_metadata_2025 huggingface dataset:
The Efficacy of Sequential Biologic Agents in Refractory Rheumatoid Arthritis after Failure of Initial DMARD and anti-Tumor Necrosis Factor Therapy
Authors: Versace Antonio Giovanni , Aragona Caterina Oriana , La Rosa Daniela , Chiappalone Marianna , Tringali Maria Concetta , De Gaetano Alberta , Moore Charles Frederick , Sangari Donatella , Roberts William Neal , Bagnato Gianluca
Published: December 2021

Introduction/Objective: The efficacy of biologic therapy in the treatment of rheumatoid arthritis (RA) has been well-established but, in practice, a quarter of patients will either not respond to the first biologic agent or will suffer an adverse event requiring a switch to a different drug. While clinical guidelines exist to help guide therapy and previous studies have examined sequential use of anti-TNF agents, there is little data to inform a multiple switch strategy. Our aim was to measure the efficacy of multiple switches of biologic in severe refractory RA. Methods: We enrolled 111 patients whose therapy with one anti-TNF agent had failed in this open-label observational study. These patients were all treated with a second biologic agent and 27 ultimately required treatment with a third. The response to the therapy and disease activity were assessed at 6 and 12 months after each switch. Results: The remission rates at 6 months were lower than previously reported and the initiation of a second biologic agent resulted in significant improvement at 12 months, including DAS remission in 36% of patients. The response in those receiving a third biologic was less pronounced, as might be expected in this relatively treatment-refractory population. In this group, only patients treated with tocilizumab had maintained remission at one year. Conclusion: Patients who do not respond to an anti-TNF agent often benefit from being switched to a second, or even third, biologic. Importantly, it may take longer than expected to fully assess the effectiveness of a second or third agent in patients with refractory disease.
Phytoplankton Phenology in the Coastal Zone of Cyprus, Based on Remote Sensing and In Situ Observations
Authors: Demetriou Monica , Raitsos Dionysios E. , Kournopoulou Antonia , Mandalakis Manolis , Sfenthourakis Spyros , Psarra Stella
Published: December 2021

Alterations in phytoplankton biomass, community structure and timing of their growth (phenology), are directly implicated in the carbon cycle and energy transfer to higher trophic levels of the marine food web. Due to the lack of long-term in situ datasets, there is very little information on phytoplankton seasonal succession in Cyprus (eastern Mediterranean Sea). On the other hand, satellite-derived measurements of ocean colour can only provide long-term time series of chlorophyll (an index of phytoplankton biomass) up to the first optical depth (surface waters). The coupling of both means of observations is essential for understanding phytoplankton dynamics and their response to environmental change. Here, we use 23 years of remotely sensed, regionally tuned ocean-colour observations, along with a unique time series of in situ phytoplankton pigment composition data, collected in coastal waters of Cyprus during 2016. The satellite observations show an initiation of phytoplankton growth period in November, a peak in February and termination in April, with an overall mean duration of ~4 months. An in-depth exploration of in situ total Chl-a concentration and phytoplankton pigments revealed that pico- and nano-plankton cells dominated the phytoplankton community. The growth peak in February was dominated by nanophytoplankton and potentially larger diatoms (pigments of 19’ hexanoyloxyfucoxanthin and fucoxanthin, respectively), in the 0–20 m layer. The highest total Chl-a concentration was recorded at a station off Akrotiri peninsula in the south, where strong coastal upwelling has been reported. Another station in the southern part, located next to a fish farm, showed a higher contribution of picophytoplankton during the most oligotrophic period (summer). Our results highlight the importance of using available in situ data coupled to ocean-colour remote sensing, for monitoring marine ecosystems in areas with limited in situ data availability.
Linking Man and Nature: Relictual Forest Coenosis with Laurus nobilis L. and Celtis australis L. in Antica Lavinium, Italy
Authors: Albani Rocchetti Giulia , Bartoli Flavia , Cicinelli Emanuela , Lucchese Fernando , Caneva Giulia
Published: December 2021

The Mediterranean basin has been a refugium for relict plant taxa and native laurophyllic forests. The Latium coasts and, especially, the Antica Lavinium site, host relict forest communities, whose natural importance is enriched by their cultural value. Here, we aim at investigating the ecological framework, cultural and historical values, and management over time, of relict communities that have Laurus nobilis and Celtis australis as their priority habitats. To achieve this, we performed vegetation surveys and we conducted statistical analyses (PCA, NMDS). Among the 45 vegetation surveys, 25 were characterized by the two target species. The PCA analysis highlighted how the L. nobilis formations and the mixed formations with C. australis present some differences but are not sufficient to describe different coenosis. The comparison among similar forests in central and southern Italy confirmed the wide coenological amplitude of L. nobilis with respect to other laurophyllic species. Antica Lavinium has an overall good preservation of laurel forest formations, but also of mixed formation with C. australis. In the area, historical, cultural, and natural characteristics mutually contributed to the development of human civilizations and plant communities, highlighting their deep linkage.
Quantum Dark Solitons in the 1D Bose Gas: From Single to Double Dark-Solitons
Authors: Kinjo Kayo , Kaminishi Eriko , Mori Takashi , Sato Jun , Kanamoto Rina , Deguchi Tetsuo
Published: December 2021

We study quantum double dark-solitons, which give pairs of notches in the density profiles, by constructing corresponding quantum states in the Lieb–Liniger model for the one-dimensional Bose gas. Here, we expect that the Gross–Pitaevskii (GP) equation should play a central role in the long distance mean-field behavior of the 1D Bose gas. We first introduce novel quantum states of a single dark soliton with a nonzero winding number. We show them by exactly evaluating not only the density profile but also the profiles of the square amplitude and phase of the matrix element of the field operator between the N-particle and (N−1)-particle states. For elliptic double dark-solitons, the density and phase profiles of the corresponding states almost perfectly agree with those of the classical solutions, respectively, in the weak coupling regime. We then show that the scheme of the mean-field product state is quite effective for the quantum states of double dark solitons. Assigning the ideal Gaussian weights to a sum of the excited states with two particle-hole excitations, we obtain double dark-solitons of distinct narrow notches with different depths. We suggest that the mean-field product state should be well approximated by the ideal Gaussian weighted sum of the low excited states with a pair of particle-hole excitations. The results of double dark-solitons should be fundamental and useful for constructing quantum multiple dark-solitons.
Tracking SARS-CoV-2 Spike Protein Mutations in the United States (January 2020—March 2021) Using a Statistical Learning Strategy
Authors: Zhao Lue Ping , Lybrand Terry P. , Gilbert Peter B. , Hawn Thomas R. , Schiffer Joshua T. , Stamatatos Leonidas , Payne Thomas H. , Carpp Lindsay N. , Geraghty Daniel E. , Jerome Keith R.
Published: December 2021

The emergence and establishment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of interest (VOIs) and variants of concern (VOCs) highlight the importance of genomic surveillance. We propose a statistical learning strategy (SLS) for identifying and spatiotemporally tracking potentially relevant Spike protein mutations. We analyzed 167,893 Spike protein sequences from coronavirus disease 2019 (COVID-19) cases in the United States (excluding 21,391 sequences from VOI/VOC strains) deposited at GISAID from 19 January 2020 to 15 March 2021. Alignment against the reference Spike protein sequence led to the identification of viral residue variants (VRVs), i.e., residues harboring a substitution compared to the reference strain. Next, generalized additive models were applied to model VRV temporal dynamics and to identify VRVs with significant and substantial dynamics (false discovery rate q-value < 0.01; maximum VRV proportion >10% on at least one day). Unsupervised learning was then applied to hierarchically organize VRVs by spatiotemporal patterns and identify VRV-haplotypes. Finally, homology modeling was performed to gain insight into the potential impact of VRVs on Spike protein structure. We identified 90 VRVs, 71 of which had not previously been observed in a VOI/VOC, and 35 of which have emerged recently and are durably present. Our analysis identified 17 VRVs ~91 days earlier than their first corresponding VOI/VOC publication. Unsupervised learning revealed eight VRV-haplotypes of four VRVs or more, suggesting two emerging strains (B1.1.222 and B.1.234). Structural modeling supported a potential functional impact of the D1118H and L452R mutations. The SLS approach equally monitors all Spike residues over time, independently of existing phylogenic classifications, and is complementary to existing genomic surveillance methods.
ANOMALIES IN THE IMPLEMENTATION OF METHODS OF TEACHING MATHEMATICS AND THEIR CONSEQUENCES
Authors: LUTFULLIN M. , LUTFULLIN V. , MATYASH L.
Published: December 2021

The article deals with the negative trends in the development of school mathematics education in the context of the relationship of inductive and deductive methods of teaching educational material. It is stated that the dominance of deduction in teaching of mathematics in high school and its separation from inductive explanations to students of mathematical concepts, definitions, rules, formulas indicates a complete disregard for pedagogical experience and K.F. Lebedyntsev and D. Polya’s methodical research. The historical causes of excessive application of the deductive method of teaching mathematics are revealed: the centuriesold practice of imitating the method of “Beginnings” by Euclid; historically short (about four centuries) period of induction method formation in scientific research; even shorter period of pedagogical induction applications practice. In order to more fully revealing the pedagogical significance of inductive methods of teaching mathematics, a brief analysis of the methodical features of lectures course on algebra, developed and delivered by I. Newton to the students of Cambridge University, was carried out.It is found out that this course has a strong inductive orientation and revealed this genius English scientist’s conviction that teaching mathematics is an art in which solving examples and problems is more important and useful than rules. It is emphasized that this I. Newton’s conviction was significantly ahead of other Western European mathematicians. The purposefulness and persistence of national mathematicians-teachers M.G. Kurganov, F.I. Busse, P.S. Guriev, O.M. Strannolyubsky, S.I. Shohor-Trotsky, K.F. Lebedyntsev in substantiating the pedagogical significance of the inductive method of teaching mathematics and its practical implementation were noted. The important general didactic significance of F.I. Busse’s views on the implementation of learning consciousness principle has been revealed. Examples of M.M. Luzin’s high school education and modern practice of training mathematics teachers are given. They show that the lack of inductive explanations of the main thing in the content of the lesson turns deductive learning into formal-deductive, accompanied by the substitution of understanding by thoughtless mechanical memorization of educational material. The exceptional relevance of the practical implementation of the methodical heritage of K.F. Lebedyntsev and D. Polya’s in the context of solving the problem of improving the quality of school mathematical education is substantiated. The most important task of of the considered problem – determinating the practical ways of its decision – is formulated.
Reorganización logística y espacial de las cadenas de suministro marítimo-portuarias en México: entre el neoproteccionismo comercial y la pandemia del COVID-19
Authors: Martner Peyrelongue Carlos Daniel
Published: December 2021

En los últimos años, las cadenas de suministro marítimo-portuarias movilizadas a través de redes globales de transporte intermodal han enfrentado escenarios adversos derivados tanto de las tensiones geopolíticas expresadas en el neoproteccionismo y la guerra comercial entre las principales potencias mundiales, como en la aparición fulminante y demoledora de la pandemia del COVID-19.

En este contexto, han quedado evidenciadas ciertas vulnerabilidades de la fragmentación logística y espacial de los procesos productivos derivados de la globalización económica que ha primado en las últimas tres décadas. La guerra comercial entre países centrales de la economía-mundo, pero sobretodo la irrupción de la pandemia del COVID-19 provocaron desajustes enormes que interrumpieron de manera abrupta la regularidad y continuidad del suministro de insumos y bienes de las cadenas productivas extensas que se articulan mayoritariamente en un espacio global a través de complejas redes de transporte marítimo e intermodal.

Derivado de lo anterior, la presente propuesta busca avanzar en la identificación de los impactos logísticos y espaciales del COVID-19 en el transporte marítimo de mercancías y en los puertos mexicanos, así como visualizar, a grandes rasgos, las tendencias emergentes de articulación espacial de las cadenas de suministro globalizadas, con la finalidad de aportar elementos cualitativos que eventualmente contribuyan o coadyuven a la construcción de escenarios post-pandemia, a partir de un enfoque teórico-metodológico de tipo estructural-sistémico, basado en la conformación de un espacio de redes y flujos globales.
La movilidad post pandemia: perfiles y usos de la micromovilidad en Barcelona
Authors: Roig-Costa Oriol , Gómez-Varo Irene , Cubells Jerònia , Marquet Oriol
Published: December 2021

La irrupción de la micromovilidad, como una alternativa sostenible e inclusiva a los modos motorizados convencionales, cobra especial importancia a raíz de la crisis del COVID-19. El objetivo del artículo es estudiar el perfil de los usuarios de estos medios de transporte y cómo la pandemia ha modificado sus desplazamientos, contribuyendo a la incipiente investigación en este ámbito. El estudio ofrece una aproximación a estas nuevas formas de movilidad en Barcelona, usando la primera encuesta realizada en la ciudad a personas usuarias de patinete eléctrico, bicicleta convencional y eléctrica compartidas, y motocicleta eléctrica compartida (n=902). El análisis presentado indica que los usuarios más habituales son hombres jóvenes y ocupados. Los motivos de desplazamiento son diversos, aunque varían en función del vehículo. Los resultados también apuntan que casi un tercio de los usuarios de micromovilidad modificó su modo de transporte habitual a raíz de la pandemia, especialmente los que antes se desplazaban en transporte público o a pie. Se cuestiona el potencial de la micromovilidad para reducir las emisiones y se apunta a las implicaciones en términos sociales, tanto por el uso diferenciado en función de las características sociodemográficas, como por el impacto en la salud y en el espacio público.
Social Media Effects and Self-harm Behaviors Among Young People
Authors: Kefala Argyro
Published: December 2021

The pervasiveness of social media in the lives of the young has prompted a growing number of studies investigating their effects on online and offline behaviors, especially when it comes to risk or self -harm behaviors. The examination of self- harm behaviors both suicidal and non-suicidal is grounded primarily in psychological and medical research but the increase in the number of adolescents who self- harm, in the last few years, expanded research into the use of social media. While there were both positive and negative accounts of the relationship of social media use to self- harm, this paper addresses the issue from a communication perspective. The main argument of this paper is that social media are complex interactive, multimodal and multidirectional environments and user created cultures that cannot be understood through traditional theories of media effects or simply in quantitative terms of uses and gratifications. Drawing from contemporary studies on media effects and social media affordances, this is an attempt to map the theoretical and methodological challenges in an effort to lay the ground for an enhanced understanding of social media as mediators in self-harming behaviors. A review of current studies in this field reconfirms the conditional and indirect character of media effects identifying at the same time the limitations and gaps in the examination of a complex behavior as it relates to multimodal “self- mass communication” (Castells, 2009) that leads to new forms of “socialized communication”. Further research on social media affordances and their effects on the cognitive and social-emotional development of young people will provide a better analytical framework not only for the assessment of self-harm but also for using social media to mitigate negative behaviors.
News Article Consumption Habits of Greek Internet Users
Authors: Avraam Evangelia , Veglis Andreas , Dimoulas Charalampos
Published: December 2021

The concept of different news consumption habits during a day has been well known for many decades in the broadcasting industry. News websites are also experiencing a drop in late afternoon traffic and a sharp drop in the evening hours. Furthermore, during the weekend, website traffic numbers appeared to be significantly different than the numbers during the weekdays. That resulted in the adoption of the concept of dayparting in the case of the internet. The existence of internet dayparts can have a significant impact on news websites since they can significantly determine their success. It is quite natural to assume that media organizations have adopted their publishing patterns to best satisfy the audience’s consumption patterns. This paper investigates those consumption patterns by conducting an extensive web survey among university students and particularly journalism and communication students that are expected to exhibit high consumption rates. The parameters being investigated include time, weekdays and weekends, and content categories. The study identified distinct periods that exhibit specific consumption patterns. The results appear to be to some degree in agreement with findings of previous studies that reported on publishing patterns, but significant differences have also been identified. Those results can provide valuable information for the implementation of successful content publishing strategies from the media organizations.
Kedudukan Dewan Kehormatan Penyelenggara Pemilu Sebagai Lembaga Quasi Peradilan Etik
Authors: - Harmoko
Published: December 2021

Penelitian ini merupakan penelitian hukum dengan kajian Kedudukan Dewan Kehormatan Penyelenggara Pemilu Sebagai Lembaga Quasi Peradilan Etik. Tujuan penelitian ini adalah untuk mengetahui kedudukan DKPP sebagai lembaga quasi peradilan etik. Metode yang digunakan dalam penelitian ini adalah penelitian hukum normatif. penelitian ini menyimpulkan bahwa kedudukan DKPP sebagai lembaga quasi peradilan etik khusus untuk penyelenggara pemilu yaitu Bawaslu, dan KPU, akan tetapi kedudukannya tidak berada di bawah kekuasaan kehakiman, hal ini dipertegas oleh Mahkamah Konstitusi dalam putusan nomor 115/PHPU.D-XI/2013 bahwa DKPP adalah salah satu organ tata usaha negara bukan bagian dari penyelenggara kekuasaan kehakiman yang diatur dalam Pasal 24 ayat (2) UUD 1945, dan bukan pula pengadilan khusus sebagaimana dalam penjelasan Pasal 27 ayat (1) UU Nomor 48 Tahun 2009. Dalam struktur lembaga negara kedudukan DKPP adalah sebagai Cabang kekuasaan keempat yang dimaknai sebagai lembaga negara independen, karena keberadaannya tidak berada dalam ranah cabang kekuasaan legislatif, eksekutif, ataupun cabang yudisial.
Pelaksanaan Tugas Polri Mendukung Penerapan Protokol Kesehatan Di Masa Pandemi Covid-19
Authors: - Iswidodo , Firmanto Taufik , Amin Muhammad
Published: December 2021

Tulisan ini bertujuan untuk meninjau dan menganalisis pelaksanaan tugas Polri guna mendukung penerapan protokol kesehatan selama pandemi Covid-19 dalam rangka terwujudya situasi kamtibmas yang kondusif. Metode yang digunakan dalam penelitian dan penulisan ini adalah metode penelitian hukum normatif, dengan beberapa pendekatan yang biasa digunakan dalam penelitian hukum, antara lain; pendekatan perundang-undangan, pendekatan konsep, pendekatan kasus, pendekatan analisis, dan pendekatan historis. Hasil temuan menunjukkan bahwa sesuai fungsinya, Polri telah melaksanakan tugas guna mendukung penerapan protokol kesehatan selama pandemi Covid-19 dalam rangka terwujudya situasi kamtibmas yang kondusif. Hal tersebut dilaksanakan dengan cara antara lain: Pertama, preventif: menerbitkan STR untuk panduan anggota melaksanakan Tindakan-tindakan pada masa pandemi dan masa transisi Normal Baru, Binmas, Sabhara, Lalu Lintas dan satker-satker lainnya terlibat aktif memberikan informasi dan penyadaran pada masyarakat. Bersama-sama dengan Pemerintah Daerah menjaga keamanan dan ketertiban masyarakat dengan memanfaatkan teknologi, misalnya dengan CCTV, drone, aplikasi-aplikasi online. Merangkul masyarakat dengan humanis, sehingga masyarakat yang terdampak Covid-19 secara kesehatan maupun secara ekonomi dapat survive. Kedua: preemtif: melakukan patrol-patroli dan razia-razia untuk mencegah kejahatan. Ketiga: penegakan hukum sebagai upaya terakhir bagi orang-orang yang melakukan perlawanan meski melanggar, termasuk memerintahkan pengendara motor dan mobil untuk putar balik karena larangan mudik Lebaran.
Hybrid Model Of Structural Equation Modeling Pls And Rfm (Recency, Frequency And Monetary) Model To Improve Bank Average Balance
Authors: Jerry Heikal  , Vitto Rialialie  , Rivelino Deva , Ign Agus Supriyono
Published: December 2021

As a business players, entrepreneurs certainly need bank products and supports that provide fast and easy services with wide-spread network in Indonesia. In this study, Structural Equation Model (SEM) identify the transaction that influence the average balance. The objects of the RFM segmentation on the selected transaction is to understand customer segment score and build a marketing strategy for each segment with different levels of loyalty for the Financial result of higher Average Balance. 

The segmentation results found three driver categories, High Recency, Mid Recency and Low Recency category. High Recency is considered Active customer where campaign category can be cross/up-selling and promotional accordingly with their Frequency and Monetary category. Mid Recency category is considered Risky customer where campaign category can be retention program accordingly with their Frequency and Monetary. Last, Low Recency is considered already Churn customer where campaign category is to conduct reactivation.
ROUTE SELECTION METHOD FOR HIGH-DENSITY WIRELESS IOT NETWORK
Authors: БУШЕЛЕНКОВ С.Н. , ПАРАМОНОВ А.И.
Published: December 2021

Приводятся результаты исследования зависимости скорости передачи данных (ПД) от параметров маршрута в беспроводной сети интернета вещей. Предложен метод выбора количества и позиций узлов для организации маршрута в сети. Метод учитывает влияние расстояния между узлами маршрута и их количества на задержку доставки данных и скорость ПД по маршруту. Метод позволяет получить выигрыш в достижимой скорости ПД по сравнению с методами выбора маршрута по критерию количества транзитных узлов.

The article presents theresults ofthe studyof thedependence of the data transfer rate on the route parameters in wireless Internet of Things (loT) networks. A method for choosing the number and positions of nodes for organizing a route in the loT network is proposed. The method takes into account the influence of the distance between the nodes of the route and their number on the delay in data delivery and the speed of data transmission along the route. The method allows one to obtain a gain in the attainable data transfer rate in comparison with methods of choosing a route based on the criterion of the number of transit nodes.
SULFONYL CHLORIDES - NOVEL SOURCE OF FREE RADICALS
Authors: Seleznev A. A. , Radchenko D. P. , Golubova S. I. , Safronov S. A. , Navrotskiy V. A.
Published: December 2021

Novel free radicals source based on sulfonyl chlorides is discovered. The radical mechanism is confirmed by 2,3-dimethyl-2,3-diphenylbutane formation under chlorosulfonated polyethylene heating in the isopropylbenzene solution. Concerted homolytic C-S and S-Cl bond scission of chlorosulfonated polyethylene thermal degradation mechanism proved by kinetic analysis. The proof of the two bonds simultaneous breaking is provided by the threefold activation energy reduction (83 kJ/mol) in comparison to the C-S and C-Cl bond dissociation energy (280 and 286 kJ/mol respectively), the 6 orders lower preexponential factor (2,46 ∙ 10 s) in Arrhenius equation in comparison to one bond cleavage (≈10-10 s) as well as the strongly negative activation entropy value (-134 J/mol∙K).
STUDY OF THE PROCESS OF ANILINE ALKYLATION WITH ALCOHOLS IN THE PRESENCE OF A SUPPORTED COPPER CATALYST
Authors: Popov Yu. V. , Mokhov V. M. , Panov A. O. , Latyshova S. E. , Razvalyaeva A. V. , Lagutin M. A.
Published: December 2021

Aniline alkylation with aliphatic alcohols in the presence of copper catalyst supported on aluminum oxide providing to obtain N-alkylanilines with high selectivity (up to 100 %).
INVESTIGATES THE INFLUENCE PHOSPHORUS-NITROGEN-CONTAINING ANTIPYRENES ON THERMAL STABILITY AND FLAME RETARDANCY OF POLYURETHANE FOAM
Authors: Zakharchenko A. A. , Vaniev M. A. , Kochnov A. B. , Borisov S. V. , Nilidin D. G. , Demidov D. V. , Novakov I. A.
Published: December 2021

The paper investigates the influence of melamine and ammonium polyphosphates on thermal degradation and flame retardancy of polyurethane foams (PUFs) composites, based on phosphorus-containing polyol. The limiting oxygen index of PUF was increased from 27,5 to 31,5 vol. % as compared to PUF composites based on phosphorus-containing polyol. The TGA of polyurethane foams demonstrated an increase of the thermal stability. Synthesized polyurethane foams have the highest category of combustion resistance.
INTERNATIONAL STRATEGIES IN MODERNIZATION TRAINING OF EDUCATIONAL MANAGEMENT SPECIALISTS IN THE EUROPEAN HIGHER EDUCATION SYSTEM
Authors: Товканець Оксана
Published: December 2021

The article analyzes the impact of international strategies for modernization of education on the content of training specialists in educational management in the European higher education system. The purpose of the article is to substantiate the influence of international strategies for the modernization of education on the content of training specialists in educational management in the European system of higher education. The research was carried out on the basis of methods of theoretical generalization; comparative analysis; methods of grouping and systematization. It is revealed that in modern conditions, among the fac-tors of development of European higher education, three important ones are substantiated, which are direct-ly related to the development of the educational space: smart growth: development of the economy based on knowledge and innovation; sustainable growth: creating an economy based on the rational use of resources, ecology and competition; inclusive growth: promoting employment, social and territorial consensus. The strategic goal of the national policy of the EU in the field of education at the beginning of the XXI century there are problems of purposeful influence on the conditions and preconditions for the implementation of the rules of law, focusing on the benefits of modernization of educational activities in the period of transfor-mation, improvement of the entire education system and the mechanism of realization of the constitutional right to education. The areas that have the greatest impact on the process of training specialists in education management in European education are identified: focus on methodological support of activities within Eu-ropean education; standardization of educational content, licensing, certification and accreditation of educa-tional institutions, recognition of qualifications at the level of higher education; improving the education management system, decentralization and diversification in education. It is emphasized that the develop-ment of human capital is at the heart of the global development strategy
Barreras para la implementación del Método Mamá Canguro
Authors: Matassini-Eyzaguirre Silvana M. , Cam-Chang Luis , Fernández-Sierra Carmen
Published: December 2021

Objetivo: Analizar y discutir las barreras de implementación del Método Mamá Canguro en un hospital del seguro social de Lima, Perú. Material y Métodos. Estudio cualitativo con diseño etnográfico realizado entre los meses de octubre 2019 y enero 2020. Observación y entrevistas a profundidad fueron las herramientas de recojo de información empleadas con madres, familiares y personal de salud (PS). Se entrevistaron a diez madres y ocho miembros del personal de salud de un hospital de la seguridad social en Lima, Perú. Resultados: Las barreras para la aplicación del método mamá canguro más resaltantes fueron las vinculadas al trato humano y al conocimiento del método por parte del personal de salud. De parte de las madres canguro son los aspectos económicos y familiares los que influyen negativamente en el involucramiento del método mamá canguro. Conclusiones: A pesar de la limitación de recursos hospitalarios, las madres manifestaron que llevar a cabo el método mamá canguro se dificulta principalmente por la débil relación con algunos miembros del personal de salud. Es importante invertir, como prioridad, en el capital humano involucrado para contribuir al traslado sostenible y efectivo del cuidado del bebé prematuro a un nivel domiciliario.
Los tsunamis por Covid-19 en Perú: El primero malo, segundo peor
Authors: Mayta-Tristán Percy
Published: December 2021

Editorial ( Sin resumen)
Shock séptico, hipercalcemia y síndrome hemofagocítico por paracoccidioidomicosis en una niña de 3 años
Authors: Rodríguez-Portilla Ricardo , Freundt-Thurne Angela Parra del Riego , Tokumura-Tokumura Carmen Carolina , Rojas-Soto Ninoska Julia , Valdés-Gómez Jorge
Published: December 2021

Objetivo: Reportar el caso de una niña que presentó shock séptico, hipercalcemia y síndrome hemofagocítico por paracoccidioidomicosis. Reporte de caso: Paciente mujer de 3 años con 2 meses de enfermedad caracterizada por fiebre, adenopatías, pérdida de peso, distensión abdominal y anemia severa. Llegó en mal estado general, desarrolló shock séptico y un síndrome hemofagocítico. Llamaba la atención la hipercalcemia y lesiones dérmicas. Se le realizó una biopsia de ganglio cervical y aspirado de médula ósea. En esta última se evidenciaron imágenes compatibles con Paracoccidioides, que fueron confirmadas con la tinción de Grocott del ganglio. Se trató con anfotericina B y trimetoprim-sulfametoxazol. La evolución fue favorable y el calcio sérico se mantuvo en rangos normales. Conclusión: Las complicaciones presentadas por paracoccidioidomicosis son raras; sin embargo, el antecedente epidemiológico y el aspirado de médula ósea pueden orientar el diagnóstico y permitir un tratamiento oportuno.
Disminución de agudeza visual, hipertelorismo y exoftalmos debido a piomucocele bilateral
Authors: Vergara-de la Rosa Esteban , Galvez-Olortegui Tomas , Galvez-Olortegui José
Published: December 2021

Introducción: El Piomucocele es la infección de un mucocele pre existente. Presentamos un varón de 22 años con disminución de agudeza visual, hipertelorismo y exolftamos. Presentó proptosis inferolateral y agudeza visual 20/80 en el lado izquierdo. Sin antecedente de traumatismo, infecciones, pólipos o cirugías. TAC con imágenes sugestivas de mucocele bilateral con efecto compresivo orbital anterior en el lado derecho y posterior en el lado izquierdo. El efecto compresivo del piomucocele etmoidal y esfenoidal en el lado izquierdo produjo compromiso del canal óptico con disminución de la agudeza visual ipsilateral. Se realizó cirugía endoscópica nasosinusal con marsupialización y descompresión, encontrándose dos piomucoceles en dirección antero posterior bien delimitados en lado derecho y un piomucocele izquierdo. La evolución fue favorable. Ésta inusual presentación obliga a considerar el compromiso ocular insospechado, principalmente en piomucoceles que comprometan senos paranasales posteriores.
Síntomas gastrointestinales como manifestaciones extrapulmonares en pacientes con COVID-19. Una revisión narrativa
Authors: Sánchez-Toro Vivian , Vásquez-Tirado Gustavo Adolfo , Meregildo-Rodríguez Edinson Dante , Segura-Plasencia Niler Manuel , Arbaiza-Avalos Yessenia Katherin , Serna-Alarcón Víctor
Published: December 2021

Introducción: La infección por SARS-CoV-2 afecta principalmente el sistema respiratorio; pero, también se han observado múltiples manifestaciones extrapulmonares en diversos sistemas y órganos. Las células epiteliales del tubo digestivo y árbol hepatobiliar expresan ECA2 y TMPRSS2 necesarios para el ingreso viral, por otro lado, el ARN viral ha sido detectado en muestras de heces, incluso después de haberse negativizado en muestras respiratorias. La presencia de manifestaciones clínicas digestivas se asocia a mayor carga viral y en ocasiones pueden ser las únicas manifestaciones de COVID-19, incluso en ausencia de síntomas respiratorios. Los síntomas más comunes son anorexia y diarrea, náuseas, vómitos y dolor abdominal, siendo este último característico de pacientes gravemente enfermos. Es muy poco frecuente la presencia de hemorragia gastrointestinal, colitis hemorrágica o hepatitis aguda. Ante un paciente con manifestaciones gastrointestinales debe considerarse a COVID-19 dentro del diagnóstico diferencial.
A construção do discurso midiático quando o estupro entra em campo
Authors: Silva Conceicao Almeida da , Azeredo Anabel Medeiros
Published: December 2021

As mídias definem-se como organismo especializado em preencher uma necessidade social de informação. No entanto, de acordo com Charaudeau (2010a) a informação é construída pela linguagem, que, inevitavelmente, produz uma visão do mundo, atribuindo-lhe um sentido particular. Portanto, ao informar, as mídias impõem ao seu destinatário a sua visão de mundo, constroem sistemas de valores e produzem sentidos. Para verificar como o discurso midiático constrói a realidade, serão analisadas manchetes de sites jornalísticos, produzidas a partir de discursos relatados que se referem a jogadores de futebol brasileiros envolvidos em casos de estupro. O modo de relatar o dito de outrem pode revelar o posicionamento do organismo de informação, que, na maioria das vezes, parece favorável aos jogadores de futebol acusados de crimes dessa natureza, reforçando o machismo e a cultura de estupro. Os pressupostos teóricos usados concentram-se nos postulados da Semiolinguística aplicados ao contrato de informação midiático.

Palavras-chave: Futebol; Estupro; Contrato de informação midiático; Discurso relatado.
Results of fundamental and applied seismological research in the Magadan region in 2016-2020
Authors: Karpenko Larisa , Aleshina Evgenia , Kurtkin Sergey , Vedernikov Evgeniy , Atrokhin Vladimir
Published: December 2021

The results of fundamental and applied research, carried out by Magadan Branch of GS RAS during 2016-2020 in Magadan and Chukotka regions are presenting. Estimation of Seismic hazard of Russia’s Northeast (Magadan region) and seismic hazard maps for recurrence periods of 500, 1000 and 5000 years in scale close to that of detailed seismic zoning (DSZ) were made in cooperation with Institute of the Earth’s Physics RAS. In course of this work the estimation of initial seismic intensity and parameters of possible ground shaking in areas of critical facilities of Magadan region were made. For all of them a seismic micro zonation was carried out with methods of direct earthquake registration and comparing acoustic impedance. As result, a seismic amplification and intensity of seismic impact on the soils under main critical facilities were obtaining. The research results are shown on detailed seismic zoning maps that are basic for building projects of objects above.
The unified system for storing and accessing geophysical data. Traditions and new approaches
Authors: Butyrin Pavel , Krasilov Sergei
Published: December 2021

The features of the development of data collection systems within the Information Processing Center (IPC) of the Geophysical Survey of the Russian Academy of Sciences (GS RAS) are presenting. Historical information is given, including technical details related to the systematization of the archive and the evolution of geophysical data formats. The historical, territorial features, as well as the experience of deploying such information systems within the Federal Research Center of the Unified State Social Service of the Russian Academy of Sciences and abroad are taken into account. A new concept of building an information system is proposed, which takes into account the requirements for scalability, reproducibility at various objects and the use of standard software. A lot of work was done to form a homogeneous archive of waveforms and an inventory of metadata for seismic stations, which resulted in the possibility of including the GS RAS in the international centers for processing geophysical information based on FDSN. Creation of a distributed collection and processing system using a cloud service allows abstracting from the territorial features of collecting and storing geophysical information, which increases the performance of the data access service and the degree of technical readiness of key system nodes.
Türkiye’de Demiryolu Taşımacılığı ve Altyapısının Demografik Etkileri
Authors: BEYZATLAR Mehmet Aldonat
Published: December 2021

Bu çalışma, Türkiye'de demiryolu taşımacılığı ve altyapısının demografik etkilerini araştırmayı amaçlamaktadır. Bu çalışmada kullanılan değişkenler, demiryolu taşımacılığı olarak demiryolları ile taşınan yolcu ve yük hareketliliği, demiryolu altyapısı olarak demiryolu ağının uzunluğu ve demografik ölçü olarak ise nüfus yoğunluğu ve kentleşmedir. Yöntem olarak dinamik bağlantılılık yaklaşımı, 1950 ile 2019 yılları arasındaki örneklem dönem için Türkiye'de demiryolları ve demografi arasındaki bağlantıyı ortaya çıkarmak için kullanılmıştır. Bu yöntem, önemli bir farklılık ve avantaj olarak da görülebilecek şekilde tüm değişkenler arasındaki etkileşimi zaman boyutunu da incelemek suretiyle zenginleştirerek ikili ve bütünleşik yönsel parametreleri elde etmek için kullanılmıştır. Bu nedenle, demiryolları ve demografi arasındaki etkileşimin belirlenmesine farklı bir bakış açısı kazandırılması literatüre önemli bir katkı sağlayabilir. Ampirik sonuçlara göre, demiryolu yolcu taşımacılığı dışındaki tüm değişkenlerin net aktarıcı olduğu bulunmuştur. Her iki demografik ölçümün (nüfus yoğunluğu ve kentleşme), net ve ikili bağlantılılık parametreleri dikkate alındığında en güçlü aktarıcı oldukları tespit edilmiştir. Kentleşme ve nüfus yoğunluğu artışı, karşılıklı olarak demiryollarının gelişimiyle dinamik ve geçişli bir süreç içerisinde etkileşim halindedir. Demiryollarının Türkiye'deki demografi ile tarihsel perspektifte yoğun bir ilişkisi olduğu konvansiyonel olmayan ve sürecin gerekliliklerine uygun bir yöntemle doğrulanmıştır.
El cultivo del arroz en la Meseta de Ibagué: desarrollo y logros
Authors: Salamanca Santos María del Pilar , Alba Sanabria Sandra Milena
Published: December 2021

En la Meseta de Ibagué se ha desarrollado una conformación histórica de una élite arrocera, que ha construido una visión de región a partir de la industrialización y el desarrollo de procesos tecnológicos más avanzados que en el resto de país para el cultivo de variedades de arroz únicas. Por otro lado, se evidencia la actual mutación de esta visión productiva propiciada por el aumento de procesos competitivos condicionados por el modelo de liberalización de los mercados comerciales, con lo que los productores no estaban familiarizados y, entonces, han cedido parte del negocio a actores dedicados exclusivamente al comercio del arroz.
FTIR INVESTIGATION ON CRYSTALLINITY OF HYDROXYPROPYL METHYL CELLULOSE-BASED POLYMERIC BLENDS
Authors:   Department of Inorganic Polymers, “Petru Poni” Institute of Macromolecular Chemistry, 41A, Gr. Ghica-Voda Alley, 700487, Iasi, Romania, ZALTARIOV MIRELA-FERNANDA
Published: December 2021

Two series of polymeric blends have been prepared based on hydroxypropyl methyl cellulose (HPMC)/polyacrylic acid (PAA) (1:1, 1:2, 1:3, 1:4) and HPMC/sodium alginate (SA) (1:30, 2:30, 3:30, 4:40) and investigated by Attenuated Total Reflectance–Fourier Transform Infrared Spectroscopy (ATR-FTIR). IR analysis confirmed the interaction between the polymeric components in the blend and the degree of structural organization. Crystallinity changes in the blends were observed as a function of a number of experimental parameters, such as temperature, composition and HPMC concentration, by determining the quantitative crystallinity indexes: Total Crystallinity Index (TCI), Lateral Order Index (LOI) and Hydrogen Bond Index (HBI).
The COVID-19 Economic Crisis in Mexico through the Lens of a Financial Conditions Index
Authors: Carrillo Julio A. , García Ana Laura
Published: December 2021

La pandemia de COVID-19 no solo generó choques reales que afectaron severamente a la actividad económica, sino también originó una amplia incertidumbre que desató un choque extremo en los mercados financieros. El presente artículo se centra en la dimensión financiera de la pandemia desde el punto de vista de una economía emergente. Para ello, se estima un índice de condiciones financieras para México desde 1993 y se encuentra que la turbulencia financiera aguda generada por la pandemia se ubica entre los cuatro episodios más importantes de estrés financiero experimentados en el país. Además, se encuentra evidencia que sugiere que las variables reales han respondido de manera diferente a choques que empeoran las condiciones financieras, que a choques que las mejoran.
The effect of tropical cyclones on economic activities: micro level evidence from Mexico for secondary and tertiary activities
Authors: Juárez-Torres Miriam , Puigvert Jonathan
Published: December 2021

Este artículo explora los efectos de los ciclones tropicales en la actividad económica de los establecimientos de los sectores manufacturero y de servicios en México. El análisis se basa en datos panel que combinan la actividad económica a nivel de establecimiento con la exposición a ciclones tropicales a nivel municipal y periodicidad mensual para estimar un modelo de rezagos distribuidos. Los resultados muestran que, después de un ciclón tropical, el establecimiento de manufactura promedio experimenta un efecto de corto plazo negativo de magnitud pequeña sobre el crecimiento de la producción. Para los establecimientos del sector servicios, el efecto es pequeño y negativo sobre el crecimiento de los ingresos, mientras que positivo, de mayor magnitud y más persistente en el crecimiento de los gastos operativos. Los datos desagregados permiten analizar la heterogeneidad de los efectos entre los sectores de manufactura y servicios.
ALANA RIVER BASIN MANAGEMENT
Authors: Sharef Arkhawan Jawhar
Published: December 2021

The main aim of this study is to highlight how the Alana River Basin (ARB) will meet future water needs and optimal monthly water distribution policies. The Water Evaluation and Planning System (WEAP) model was applied in order to determine the ARB and the operation plan policy using data for the past 16 years (2000-2015). The model result determined that the current regulations and practices regarding water use and pollution patterns are inadequate. An ideal scheme has been developed and implemented for various scenarios such as domestic water needs, irrigation water, and tourism. Four scenarios have been considered in this study, which are basic scenarios, a higher population growth scenario, a severe flow requirements scenario, and a scenario of adding dams. Comparisons show that the demand for water from April to September is high due to the agriculture season and the high temperature. The maximum demand for water is 3 million cubic meters, which occurs in August, while the proposed dam provides only 2 million cubic meters. In addition, the maximum demand for domestic water is 0.4733 MCM and the minimum is 0.36978 MCM, which is roughly the same level of water demand for every month. Accordingly, the government should start supplementing the Gali Bale dam. However, it is not a sufficient dam to cover the water demand, so the construction of additional dams is strongly suggested.
YIELD STABILITY EVALUATION FOR BREAD WHEAT GENOTYPES UNDER ENVIRONMENTAL VARIATIONS
Authors: Al-Falahi M. A. H. , Dawod Kh. M. , Omer Fathi. A.
Published: December 2021

This study was aimed to evaluation the yield stability of twenty bread wheat genotypes that cultivated at two locations (fields of the College of Agricultural Engineering Sciences of Duhok and Zenawa district) during the 2019 - 2020 with two planting dates in each location using randomized complete block design with three replications. The results of the combined analysis of variance showed that the mean square for each of the environments, genotypes and their interactions were highly significant for all studied traits, and the variations due to the environments were greater than those of each of the genotypes and the interactions for most of the studied traits. The values ​​of broad sense heritability ranged between 44.44% for spike length and 93.27% for grain weight per spike. The results of the stability parameters showed that the genotype Apst-12-85578 was highly stable for grains weight per spike and final grain yield followed by each of Adana, Bora, and Apst-6-85576 genotypes which showed high stability for the grain yield.
USING OF TRIPLE-TREATED WASTEWATER IN AGRICULTURAL IRRIGATION IN AL-AHSA OASIS, SAUDI ARABIA.
Authors: El-Sebaei M. N. , Osman R. T. , Mansour H. E.H. , Al-Asmari M. A.
Published: December 2021

The agricultural sector consumes about 84% of the total actual water consumption annually in Kingdom of Saudi Arabia, therefore, the research depends on questionnaire data that was judged before being used in the study of a random sample of 355 farms from Al-Ahsa Oasis which irrigated with two types of water (groundwater, triple-treated wastewater) to measure the economic impact of the using of triple-treated wastewater in irrigating palm and lemon crops, the results indicated a statistically significant correlation between the extent of farmers'  which using of triple treated wastewater in irrigation and all of: size of the tenure, family size and the educational level of the farmer. While the relationship was negative with all of: age of the farmer, and number of years of his experience. The results showed that the productivity of dunums on farms irrigated with triple-treated wastewater increased by 0.32, 0.30, 0.22 tons, representing about 19.2%, 17.2%, 16.8% compared to which using groundwater for Alkhallas palm, Alrziz palm and lemon.