bluuebunny/crossref_metadata_2025 huggingface dataset:
“This Country Is Not for Anyone”: Explanations of Low National Pride in the Czech Republic
Authors: Vlachová Klára
Published: June 2019

National pride is a group-based and sometimes collective emotion that people feel toward their nation-state. It is often measured by the general national pride item in cross-national surveys. Czechs are among those nations whose members express low levels of general national pride in comparison with those of other nations in the European Union. Scholars debate the extent to which general national pride is influenced by social desirability or other identifiable reasons. The goal of this article is to identify the specific reasons that influence general national pride in the Czech Republic. Using data from the October 2015 round of the survey Naše společnost, I examine what makes Czechs proud of their country. Among frequently mentioned reasons for national pride are the country’s beauty, nature, cities, and history, as well as respondents’ family and friends. Results of an ordinal regression analysis based on the European Values Study 2008 data confirm that general national pride is significantly influenced by political interest, confidence in government and satisfaction with the development of democracy, happiness, and social trust.
Bridging Past and Present Traumas: The Emergence of Kosovo Serb Ethnoscape in the Dynamic Interaction between the Enclaved Environment and History Textbooks’ Content
Authors: Fort Emilie
Published: June 2019

This article deals with the use of history textbooks imported from Serbia in the specific context of Kosovo Serb enclavement. It provides a content analysis of history textbooks used by Kosovo Serb pupils in Kosovo in terms of their contribution to Kosovo Serb collective identity building. This article focuses on the interaction between the enclaved environment within which Kosovo Serbs have lived since 1999 and the narratives contained in the history textbooks, to highlight how this interaction influences the way Kosovo Serbs consider their identity. First, I start by showing that history textbooks used by Kosovo Serbs in Kosovo emphasize religious identity. Next, I argue that dialogic relation between past and present, understood through the dynamic interaction between the enclaved environment and history textbook narratives, contributes to the emergence of enclaves as ethnoscapes.
Self-rated amygdala activity: an auto-biological index of affective distress
Authors: MacDuffie Katherine E. , Knodt Annchen R. , Radtke Spenser R. , Strauman Timothy J. , Hariri Ahmad R.
Published: June 2019

Auto-biological beliefs—beliefs about one’s own biology—are an understudied component of personal identity. Research participants who are led to believe they are biologically vulnerable to affective disorders report more symptoms and less ability to control their mood; however, little is known about the impact of self-originating beliefs about risk for psychopathology, and whether such beliefs correspond to empirically derived estimates of actual vulnerability. Participants in a neuroimaging study (n = 1256) completed self-report measures of affective symptoms, perceived stress, and neuroticism, and an emotional face processing task in the scanner designed to elicit threat responses from the amygdala. A subsample (n = 63) additionally rated their own perceived neural response to threat (i.e., amygdala activity) compared to peers. Self-ratings of neural threat response were uncorrelated with actual threat-related amygdala activity measured via BOLD fMRI. However, self-ratings predicted subjective distress across a variety of self-report measures. In contrast, in the full sample, threat-related amygdala activity was uncorrelated with self-report measures of affective distress. These findings suggest that beliefs about one’s own biological threat response—while unrelated to measured neural activation—may be informative indicators of psychological functioning.
How Do Observers Assess Resolve?
Authors: Kertzer Joshua D , Renshon Jonathan , Yarhi-Milo Keren
Published: June 2019

Despite a plethora of theoretical frameworks, IR scholars have struggled with the question of how observers assess resolve. We make two important contributions in this direction. Conceptually, we develop an integrative framework that unites otherwise disconnected theories, viewing them as a set of heuristics actors use to simplify information-rich environments. Methodologically, we employ a conjoint experiment that provides empirical traction impossible to obtain using alternative research designs. We find that ordinary citizens are ‘intuitive deterrence theorists’ who focus to a great extent on capabilities, stakes, signals and past actions in judging resolve. We also find that observers see democracies as less resolved than autocracies (not more), casting doubt on key propositions of democratic credibility theory. Finally, a conceptual replication shows that a group of elite decision makers converge with the US public in how they interpret costly signals, and in viewing democracies as less resolved than autocracies.
Recaptures of feralBactrocera dorsalisandB. umbrosa(Diptera: Tephritidae) males after feeding on methyl eugenol
Authors: Tan K.-H.
Published: June 2019

Two major fruit fly pest species,Bactrocera dorsalisandB. umbrosa, are strongly attracted to methyl eugenol (ME) found in >450 plant species. They are, however, exclusive pollinators of certain daciniphilous (attracting Dacini fruit flies)Bulbophyllumorchids. A comparison between the recaptures of feral males after feedingad libitumon 0.6 mg ME (simulating an average floral quantity of an orchid flower–Trial 1) and 480 mg in Trial 2 was investigated using the non-invasive capture-mark-release-recapture (CMRR) technique. Based on daily CMRR over a 16-day period, using a different colour enamel paint each day, percentages ofB. dorsalismales recaptured in Trial 1 were significantly higher than those in Trial 2. However, forB. umbrosa, percentages of recaptures for different day-specific colours were highly variable due to low fly numbers captured/day. In Trial 1, of 756B. dorsalismales released, 36.4% were recaptured once, 7.7 twice, 2.4 three times and 0.4 four times. While in Trial 2 of 1157 released males, 6% were recaptured once and 0.3% twice. Of 67B. umbrosamales released, 28.4% were recaptured once and none more than once in Trial 1. Nevertheless, of 119 flies released in Trial 2, 25.2% were recaptured once and 3.3% twice. Overall, many marked males did return to a single ME-source to ‘refuel’ ME (a sex pheromone precursor). The results also show that a relatively high number of flies paid multi-visitations to a single 0.6 mg ME-source and indicate that the presence of natural ME-sources may impact area-wide IPM programmes.
Habitat visualization, acquisition features and necessity of the gammaproteobacterial symbiont of pistachio stink Bug, Acrosternum heegeri (Hem.: Pentatomidae)
Authors: Kashkouli M. , Fathipour Y. , Mehrabadi M.
Published: June 2019

Plant-sucking stinkbugs are especially associated with mutualistic gut bacterial symbionts. Here, we explored the symbiotic relationship of a pistachio stinkbug, Acrosternum heegeri Fieber by histological, fluorescence in situ hybridization (FISH), real-time PCR and molecular phylogenetic techniques. Furthermore, the effects of the symbiont on the resting/wandering behaviors of the newborn nymphs, pre-adult survival rates, and stage compositions were investigated. Transmission electron microscopy and real-time PCR analyses showed that a rod-shaped gammaproteobacterium was persistently located within the posterior midgut crypts. Molecular phylogenetic and FISH techniques strongly suggested that this symbiont should be placed in the genus Pantoea of the Enterobacteriales. Scanning electron microscopy confirmed the presence of the bacterial cells on the egg surface which the surface sterilization of the eggs resulted in the successful removal of the symbiont from the eggs. Symbiotic and aposymbiotic A. heegeri showed no significant differences in the wandering behaviors of the first nymphal stages, while the symbiont-free insects suffered retarded growth and lower survivability. Together, the results highlight the habitat and acquisition features of Pantoea symbiont and its contribution in A. heegeri biology that might help us for better pest management in the future.
Disturbance and competition drive diversity effects in cabbage–aphid–onion systems with intra-specific genetic variation
Authors: Guilbaud C.S.E. , Khudr M.S.
Published: June 2019

Decreased reliance on pesticides can be achieved through a clever use of eco-evolutionary knowledge via intercropping economically valuable crops with companion plants that can hamper pest outbreaks. We created a greenhouse multi-layered microcosm system to test two potato peach aphid clones, performing alone or in competition, on mixes of genetically variable cultivars of cabbage, with and without onion. The onion acted as a nuisance/disturbance for the pest, which was generally for the benefit of the cabbage albeit both plants sharing space and nutrients. The onion effect was context-specific and differed by aphid genotype. Onion variable nuisance negatively affected the numbers of one aphid genotype (green) across all contexts, while the other genotype (pink) numbers were decreased in two contexts only. However, the green performed better than the pink on all cases of cabbage di-mixes despite its numbers being capped when the onion was present. Further, there was also a general aphid propensity to wander off the plant along with a differential production of winged morphs to escape the onion-affected environments. Moreover, through a comparative increase in dry mass, which was subject to onion and aphid effects, a diversity effect was found where the cabbages of fully genetically variable microcosms sustained similar final dry mass compared with non-infested microcosms. Our findings provide fresh insights into the use of multi-layered contextual designs that not only allow disentangling the relative effects of genetic variation and modes of interaction, but also help integrate their benefits into pest management in view of companion planting.
Petrogenesis of high Ba–Sr plutons with high Sr/Y ratios in an intracontinental setting: evidence from Early Cretaceous Fushan monzonites, central North China Craton
Authors: Li Xi-Yao , Li San-Zhong , Huang Feng , Wang Yong-Ming , Yu Sheng-Yao , Cao Hua-Hua , Xie Wei-Ming
Published: June 2019

Geochronological, major and trace element, and Sr–Nd–Hf isotopic data are reported for the monzonitic rocks of the Fushan pluton in the Taihang Mountains, central North China Craton, in order to investigate their sources, petrogenesis and tectonic implications. Zircon U–Pb dating results reveal that the Fushan pluton was emplaced during the Early Cretaceous (∼126–124 Ma). The monzonites and quartz monzonites are mainly characterized by calc-alkaline and magnesian features and display light rare earth element (LREE) enrichment and flat heavy REE (HREE) patterns with slightly positive Eu anomalies. They have similar whole-rock initial87Sr/86Sr ratios (0.70653–0.70819),εNd(t) values (−13.6 to −18.6) and zirconεHf(t) values (−21.8 to −17.3). The primary magma of the Fushan pluton was derived from the partial melting of a spinel-facies amphibole-bearing ancient enriched lithospheric mantle. The monzonitic rocks also have high Ba–Sr and low Y and Yb contents, with high Sr/Y and La/Yb ratios. These geochemical features of monzonitic rocks are not only inherited from the magma source but also significantly enhanced by crystal fractionation during magmatic evolution; e.g. hornblende fractionation increased the Ba–Sr concentrations and Sr/Y ratios. During the Early Cretaceous, the slab sinking and roll-back of the Palaeo-Pacific Plate could have created an ancient big mantle wedge beneath East Asia and induced a lithospheric extensional process in the central North China Craton within an intracontinental setting.
The electromagnetic radiation whose decay violates the inverse-square law: detailed mathematical treatment of an experimentally realized example
Authors: Ardavan Houshang
Published: June 2019

I analyse and numerically evaluate the radiation field generated by an experimentally realized embodiment of an electric polarization current whose rotating distribution pattern moves with linear speeds exceeding the speed of light in vacuum. I find that the flux density of the resulting emission (i) has a dominant value and is linearly polarized within a sharply delineated radiation beam whose orientation and polar width are determined by the range of values of the linear speeds of the rotating source distribution, and (ii) decays with the distance

$d$

from the source as

$d^{-\unicode[STIX]{x1D6FC}}$

in which the value of

$\unicode[STIX]{x1D6FC}$

lies between

$1$

and

$2$

(instead of being equal to

$2$

as in a conventional radiation) across the beam. In that the rate at which boundaries of the retarded distribution of such a source change with time depends on its duration monotonically, this is an intrinsically transient emission process: temporal rate of change of the energy density of the radiation generated by it has a time-averaged value that is negative (instead of being zero as in a conventional radiation) at points where the envelopes of the wave fronts emanating from the constituent volume elements of the source distribution are cusped. The difference in the fluxes of power across any two spheres centred on the source is in this case balanced by the change with time of the energy contained inside the shell bounded by those spheres. These results are relevant not only to long-range transmitters in communications technology but also to astrophysical objects containing rapidly rotating neutron stars (such as pulsars) and to the interpretation of the energetics of the multi-wavelength emissions from sources that lie at cosmological distances (such as radio and gamma-ray bursts). The analysis presented in this paper is self-contained and supersedes my earlier works on this problem.
‘At Least the Government is Watching out for us Now’: Dalit perceptions and experiences of governance and cash transfers in three villages in Sarlahi, Nepal
Authors: DRUCZA KRISTIE
Published: June 2019

This article provides qualitative case studies and applies citizenship theory to reveal the way in which being in receipt of a cash transfer can help local poor and excluded Dalits to understand what it means to be a citizen of Nepal's state. Cash transfers can contribute to an individual's subjective sense of inclusion and citizenship. Although Dalits encounter disparities and rights abuses when dealing with local government over their cash transfer entitlements, their responses reveal a sense of agency in the positive way in which they interpret their entitlements. Although they may be mistreated at the local level, they feel valued because the central ‘state’ recognizes their plight and identity. Cash transfers are understood by Dalits through the lens of social exclusion, patronage, and the hierarchical society in which they live. They are an effective way of reaching large numbers of formerly excluded citizens and indicate that the state now includes them. As such, they can contribute towards building an inclusive state.
Characterization of a novel glycosylated glutathione transferase of Onchocerca ochengi, closest relative of the human river blindness parasite
Authors: Rose Clair , Praulins Giorgio , Armstrong Stuart D. , Casas-Sanchez Aitor , Davis Jem , Molyneux Gemma , Yunta Cristina , Stead Zenaida , Prescott Mark , Perally Samirah , Rutter Anne , Makepeace Benjamin L. , La Course E. James , Acosta-Serrano Alvaro
Published: June 2019

Filarial nematodes possess glutathione transferases (GSTs), ubiquitous enzymes with the potential to detoxify xenobiotic and endogenous substrates, and modulate the host immune system, which may aid worm infection establishment, maintenance and survival in the host. Here we have identified and characterized a σ class glycosylated GST (OoGST1), from the cattle-infective filarial nematode Onchocerca ochengi, which is homologous (99% amino acid identity) with an immunodominant GST and potential vaccine candidate from the human parasite, O. volvulus, (OvGST1b). Onchocerca ochengi native GSTs were purified using a two-step affinity chromatography approach, resolved by 2D and 1D SDS-PAGE and subjected to enzymic deglycosylation revealing the existence of at least four glycoforms. A combination of lectin-blotting and mass spectrometry (MS) analyses of the released N-glycans indicated that OoGST1 contained mainly oligomannose Man5GlcNAc2 structure, but also hybrid- and larger oligommanose-type glycans in a lower proportion. Furthermore, purified OoGST1 showed prostaglandin synthase activity as confirmed by Liquid Chromatography (LC)/MS following a coupled-enzyme assay. This is only the second reported and characterized glycosylated GST and our study highlights its potential role in host-parasite interactions and use in the study of human onchocerciasis.
Sexual orientation and mental health over the life course in a birth cohort
Authors: Spittlehouse J. K. , Boden J. M. , Horwood L. J.
Published: June 2019

Background

Sexual minority individuals consistently report higher rates of mental disorder than heterosexuals. However, much of the research has methodological limitations related to the classification of sexuality, the use of cross-sectional data and problematic sampling procedures such as using convenience samples.

Methods

We used longitudinal data from a birth cohort enrolled in the Christchurch Health and Development Study (n = 1040). Latent class analysis was used to classify participants sexuality based on self-report data of sexual behaviour, attraction, identity and fantasy, gathered over five assessments between the ages of 18 and 35 years. Mental health and substance use outcome data were gathered at four assessments between the ages of 21 and 35 years. Potential covariate variables were collected during childhood.

Results

The latent class analysis identified four groups interpreted as: ‘heterosexual’ 82%, ‘mostly heterosexual’ 12.6%, ‘bisexual’ 3.5% and ‘gay/lesbian’ 1.9%. In the sexual minority groups, women outnumbered men by at least 2:1. Pooled rates for mental health disorders of depression, anxiety disorders, suicidal ideation, cannabis abuse and total disorders, after adjustment for childhood covariate variables, were significantly higher in the sexual minority groups (p < 0.01). The strength of association between sexuality group and mental health outcomes did not differ according to sex. Fluidity in sexuality reports appeared unrelated to risk of mental health outcomes.

Conclusions

Over the life course, membership of a sexual minority group is clearly associated with mental health problems of depression, anxiety and suicidal ideation regardless of the age when same-sex attraction, behaviour, identity or fantasy is expressed.
Psychosis breakthrough on antipsychotic maintenance: results from a nationwide study
Authors: Rubio Jose M. , Taipale Heidi , Correll Christoph U. , Tanskanen Antti , Kane John M. , Tiihonen Jari
Published: June 2019

Background

There is uncertainty about the incidence of breakthrough psychosis in treatment adherent patients, and the role that factors, such as cumulative antipsychotic exposure, play in this phenomenon.

Methods

In a nationwide cohort of individuals treated for schizophrenia-spectrum disorders in Finland between 1 January 1996 and 31 December 2015, ‘Breakthrough Psychosis on Antipsychotic Maintenance Medication’ (BAMM) was defined as hospitalization for psychosis despite ongoing continuous treatment with long-acting injectable antipsychotics (LAIs) or oral antipsychotics (OAPs) for ⩾8 weeks. Incidence rates, survival curves, and risk factors were presented.

Results

In a cohort of 16 031 continuous LAI treatment episodes with virtually assured adherence [median duration = 441 days, interquartile range (IQR) = 155–1277], BAMM incidence was 31.5%. For 42 867 OAPs treatment episodes (median duration = 483 days, IQR = 167–1491), for whom adherence was modeled by the PRE2DUP method, BAMM incidence was 31.1%. Factors related to illness instability at treatment onset were associated with BAMM, although median time to BAMM was 291 days (IQR = 121–876) for LAIs and 344 days (IQR = 142–989) for OAPs, and 27.4% (N= 1386) of the BAMM events in the LAI, and 32.9% (N= 4378) in the OAP group occurred despite >1 year since last hospitalization at treatment onset. Cumulative antipsychotic exposure was not a consistent risk factor.

Conclusion

BAMM was relatively common even when adherence was confirmed with LAIs. Illness instability at treatment onset accounted for most cases, but relapse after years of continuous treatment was still prevalent. There was insufficient evidence to support causality between cumulative antipsychotic exposure and BAMM. Future research needs to address the role of symptom severity and neurobiology in BAMM.
Dynamics of proteins in solution
Authors: Grimaldo Marco , Roosen-Runge Felix , Zhang Fajun , Schreiber Frank , Seydel Tilo
Published: June 2019

The dynamics of proteins in solution includes a variety of processes, such as backbone and side-chain fluctuations, interdomain motions, as well as global rotational and translational (i.e. center of mass) diffusion. Since protein dynamics is related to protein function and essential transport processes, a detailed mechanistic understanding and monitoring of protein dynamics in solution is highly desirable. The hierarchical character of protein dynamics requires experimental tools addressing a broad range of time- and length scales. We discuss how different techniques contribute to a comprehensive picture of protein dynamics, and focus in particular on results from neutron spectroscopy. We outline the underlying principles and review available instrumentation as well as related analysis frameworks.
Making energy personal: policy coordination challenges in UK smart meter implementation
Authors: Giest Sarah
Published: June 2019

Governments are increasingly facilitating the roll-out of so-called “smart meters”, a technology for measuring energy consumption that are able to transmit and receive data using a form of electronic communication. However, implementation has been slow or even stalled. To identify some of the causes for this, the policy coordination perspective serves as a lens to unravel the different elements involved in smart meter implementation. The research adds the demand and supply dimension to account for market dynamics and public engagement challenges in the process. A case study of the UK finds that government efforts are challenged by the timely and coherent coordination of diverse stakeholders and regulatory measures.
Population Adjustment Methods for Indirect Comparisons: A Review of National Institute for Health and Care Excellence Technology Appraisals
Authors: Phillippo David M. , Dias Sofia , Elsada Ahmed , Ades A. E. , Welton Nicky J.
Published: June 2019

Objectives

Indirect comparisons via a common comparator (anchored comparisons) are commonly used in health technology assessment. However, common comparators may not be available, or the comparison may be biased due to differences in effect modifiers between the included studies. Recently proposed population adjustment methods aim to adjust for differences between study populations in the situation where individual patient data are available from at least one study, but not all studies. They can also be used when there is no common comparator or for single-arm studies (unanchored comparisons). We aim to characterise the use of population adjustment methods in technology appraisals (TAs) submitted to the United Kingdom National Institute for Health and Care Excellence (NICE).

Methods

We reviewed NICE TAs published between 01/01/2010 and 20/04/2018.

Results

Population adjustment methods were used in 7 percent (18/268) of TAs. Most applications used unanchored comparisons (89 percent, 16/18), and were in oncology (83 percent, 15/18). Methods used included matching-adjusted indirect comparisons (89 percent, 16/18) and simulated treatment comparisons (17 percent, 3/18). Covariates were included based on: availability, expert opinion, effective sample size, statistical significance, or cross-validation. Larger treatment networks were commonplace (56 percent, 10/18), but current methods cannot account for this. Appraisal committees received results of population-adjusted analyses with caution and typically looked for greater cost effectiveness to minimise decision risk.

Conclusions

Population adjustment methods are becoming increasingly common in NICE TAs, although their impact on decisions has been limited to date. Further research is needed to improve upon current methods, and to investigate their properties in simulation studies.
A Portrait of Late Life Homelessness in Calgary, Alberta
Authors: Milaney Katrina , Kamran Hasham , Williams Nicole
Published: June 2019

Le présent article vise à évaluer les problèmes de santé des Calgariens de plus de 50 ans en situation d’itinérance chronique, à identifier les manques en matière de services pour cette population et à cerner les prédicteurs de l’itinérance chronique, tels que les traumatismes durant l’enfance, qui pourraient être atténués par des modifications touchant les politiques ou la prestation de services. Des personnes en situation d’itinérance, dont trois cents provenaient de refuges d’urgence, ont été recrutées à Calgary (Canada) à hiver 2016. Les logiciels Excel et SPSS ont été utilisés pour l’analyse des statistiques descriptives des participants qui ont été séparés en deux groupes, soit les répondants de 50 ans et plus (n = 142) et ceux de moins de 50 ans (n = 158). Plus de la moitié des participants étaient en situation d’itinérance continue depuis plus de dix ans. Les personnes plus âgées ont fait état de problèmes de santé complexes et d’obstacles importants pour l’accès aux soins de santé, associés notamment à leurs problèmes financiers, aux listes d’attente et au fait de ne pas recevoir d’aide malgré leurs demandes. Les répondants plus âgés ont rapporté des taux de traumatismes durant l’enfance inférieurs à ceux des répondants plus jeunes, bien que la moyenne de ces taux soit 2,5 fois supérieure à celle de la population générale. La reconnaissance des effets croisés et cumulatifs de l’itinérance de long terme et de l’âge pourrait guider la modification des politiques visant à réduire les cloisonnements entre les services publics. Étant donné que les personnes âgées en situation d’itinérance sont plus à risque de mourir prématurément, elles devraient être priorisées par les programmes d’aide au logement. Des interventions adaptées au contexte culturel et tenant compte des traumatismes seraient nécessaires pour répondre aux besoins à la fois variés et complexes de ce groupe vulnérable.
Molecular characterisation of multidrug-resistantMycobacterium tuberculosisisolates from a high-burden tuberculosis state in Brazil
Authors: Salvato R. S. , Schiefelbein S. , Barcellos R. B. , Praetzel B. M. , Anusca I. S. , Esteves L. S. , Halon M. L. , Unis G. , Dias C.F. , Miranda S. S. , de Almeida I. N. , de Assis Figueredo L. J. , Silva E. C. , Kritski A. L. , Dalla Costa E. R. , Rossetti M. L. R.
Published: June 2019

Tuberculosis (TB) is the leading cause of death among infectious diseases worldwide. Among the estimated cases of drug-resistant TB, approximately 60% occur in the BRICS countries (Brazil, Russia, India, China and South Africa). Among Brazilian states, primary and acquired multidrug-resistant TB (MDR-TB) rates were the highest in Rio Grande do Sul (RS). This study aimed to perform molecular characterisation of MDR-TB in the State of RS, a high-burden Brazilian state. We performed molecular characterisation of MDR-TB cases in RS, defined by drug susceptibility testing, using 131Mycobacterium tuberculosis (M.tb)DNA samples from the Central Laboratory. We carried out MIRU-VNTR 24loci, spoligotyping, sequencing of thekatG,inhA andrpoB genes and RDRiosublineage identification. The most frequent families found were LAM (65.6%) and Haarlem (22.1%). RDRiodeletion was observed in 42 (32%) of theM.tbisolates. Among MDR-TB cases, eight (6.1%) did not present mutations in the studied genes. In 116 (88.5%)M.tbisolates, we found mutations associated with rifampicin (RIF) resistance inrpoB gene, and in 112 isolates (85.5%), we observed mutations related to isoniazid resistance inkatG andinhA genes. An insertion of 12 nucleotides (CCAGAACAACCC) at the 516 codon in therpoB gene, possibly responsible for a decreased interaction of RIF and RNA polymerase, was found in 19/131 of the isolates, belonging mostly to LAM and Haarlem families. These results enable a better understanding of the dynamics of transmission and evolution of MDR-TB in the region.
Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections
Authors: Komadina N. , Sullivan S. G. , Kedzierska K. , Quiñones-Parra S. M. , Leder K. , McVernon J.
Published: June 2019

The epidemiology of H5N1 and H7N9 avian viruses of humans infected in China differs despite both viruses being avian reassortants that have inherited six internal genes from a common ancestor, H9N2. The median age of infected populations is substantially younger for H5N1 virus (26 years) compared with H7N9 virus (63 years). Population susceptibility to infection with seasonal influenza is understood to be influenced by cross-reactive CD8+ T cells directed towards immunogenic peptides derived from internal viral proteins which may provide some level of protection against further influenza infection. Prior exposure to seasonal influenza peptides may influence the age-related infection patterns observed for H5N1 and H7N9 viruses. A comparison of relatedness of immunogenic peptides between historical human strains and the two avian emerged viruses was undertaken for a possible explanation in the differences in age incidence observed. There appeared to be some relationship between past exposure to related peptides and the lower number of H5N1 virus cases in older populations, however the relationship between prior exposure and older populations among H7N9 virus patients was less clear.
Data assimilation: The Schrödinger perspective
Authors: Reich Sebastian
Published: June 2019

Data assimilation addresses the general problem of how to combine model-based predictions with partial and noisy observations of the process in an optimal manner. This survey focuses on sequential data assimilation techniques using probabilistic particle-based algorithms. In addition to surveying recent developments for discrete- and continuous-time data assimilation, both in terms of mathematical foundations and algorithmic implementations, we also provide a unifying framework from the perspective of coupling of measures, and Schrödinger’s boundary value problem for stochastic processes in particular.
Derivative-free optimization methods
Authors: Larson Jeffrey , Menickelly Matt , Wild Stefan M.
Published: June 2019

In many optimization problems arising from scientific, engineering and artificial intelligence applications, objective and constraint functions are available only as the output of a black-box or simulation oracle that does not provide derivative information. Such settings necessitate the use of methods for derivative-free, or zeroth-order, optimization. We provide a review and perspectives on developments in these methods, with an emphasis on highlighting recent developments and on unifying treatment of such problems in the non-linear optimization and machine learning literature. We categorize methods based on assumed properties of the black-box functions, as well as features of the methods. We first overview the primary setting of deterministic methods applied to unconstrained, non-convex optimization problems where the objective function is defined by a deterministic black-box oracle. We then discuss developments in randomized methods, methods that assume some additional structure about the objective (including convexity, separability and general non-smooth compositions), methods for problems where the output of the black-box oracle is stochastic, and methods for handling different types of constraints.
Promoting Diversity and Inclusion through Engagement: The APSA 2018 Hackathon
Authors: Htun Mala
Published: June 2019

Organizations—from academic and professional associations to private corporations and police forces—face challenges promoting diversity and inclusion among their workers and affiliates. Instead of training and regulations, recent research recommends mechanisms that engage managers and leaders in activities that involve behavioral changes. This article describes how we put the managerial engagement approach into practice by organizing a “Diversity and Inclusion Hackathon” at the 2018 annual meeting of the American Political Science Association. With 11 teams focused on a range of topics, the hackathon attracted more than 200 people and produced multiple outputs. It engaged scholars from a range of backgrounds, social identities, institutions, ranks, and beliefs in the generation of new norms, programmatic ideas, and plans for the profession. Although we cannot infer causality, analysis of the APSA Annual Meeting evaluation survey reveals that hackathon participants are significantly more likely to express positive perceptions of the conference.
CONTRACTUALIST JUSTIFICATION AND THE DIRECTION OF A DUTY
Authors: Jonker Julian
Published: June 2019

To whom is a duty owed? Contractualism answers with an interest theory of direction. As such, it faces three challenges. The Conceptual Challenge requires acknowledgment that a duty is conceptually distinct from an interest. The Extensional Challenge requires an account of cases in which one who is owed a duty does not take an interest in the duty, or does not take as much of an interest as someone who is not owed the duty. The Positivist Challenge requires explanation of the great flexibility of law and other social practices in positing duties that do not reflect the landscape of moral interests. Contractualism can be shown to meet these challenges once we acknowledge the centrality of the idea of a generic interest. Focusing on generic interests also illuminates the distinctive form of respect involved in directedness.
Separation of Powers and Alternative Dispute Resolution before the European Court of Human Rights
Authors: Jenart Cedric , Leloup Mathieu
Published: June 2019

Alternative dispute resolution procedures before the European Court of Human Rights – The state agent, a member of the executive branch, tasked with representing the respondent state – Judicial and legislative branches of the respondent state limited or bound by concessions by the state agent – Convention framework effectively increases the power of the executive branch to the detriment of the other branches of government in the respondent state – Tension with national separation of powers – Possible solutions on a national and international level
A Feminine Advantage? Delineating the Effects of Feminine Trait and Feminine Issue Messages on Evaluations of Female Candidates
Authors: Bauer Nichole M.
Published: June 2019

Current scholarship offers conflicting conclusions about whether female candidates have a feminine advantage or a disadvantage. Previous work does not consider whether voters respond similarly to all types of messages that might emphasize feminine stereotypes, such as feminine trait and feminine issue messages. I argue that voters will respond differently to trait-based feminine messages relative to issue-based feminine messages. I test the effects of trait-based and issue-based feminine messages through two survey experiments. The results consistently show that emphasizing feminine traits harms female candidates, whereas emphasizing feminine issues helps female candidates. I use role congruity theory to argue that feminine traits activate feminine stereotypes about women, and feminine issues do not activate these stereotypes. I also show that trait-based and issue-based feminine messages affect Democratic and Republican female candidates in very different ways. These results have implications for the ability of women to win elected office and reverse the pervasive underrepresentation of women in politics.
The Women's Movement in Timor-Leste and Potential for Social Change
Authors: Niner Sara Louise , Loney Hannah
Published: June 2019

The postconflict period in Timor-Leste is significant for the status of women and the struggle for gender equality. Women today face cultural and political pressure to conform to patriarchal demands, driven by a complex history of conflict, colonialism and changing customary practices. The contemporary East Timorese women's movement, largely a coalition of local NGOs, key women leaders and parliamentarians, has successfully driven the introduction of progressive egalitarian laws and policy, but it continues to grapple with the deeper changes in social practices required for systemic change. We argue that a better understanding of the history of the women's movement, forged within an anticolonial, nationalist independence movement, alongside a conceptualization of the intersecting structures that have shaped the capacity for East Timorese women to effect social change in their communities and nation, is necessary to fully realize the movement's goals and potential. Situating the movement within this framework provides new perspectives on these successes and on strategizing for the transformation of gender relations to make gender equality a lasting reality in everyday practice in contemporary Timor-Leste.
Who am I without anorexia? Identity exploration in the treatment of early stage anorexia nervosa during emerging adulthood: a case study
Authors: Koskina A. , Schmidt U.
Published: June 2019

Emerging adulthood (age 18–25 years) is a distinct developmental phase, characterized by multiple life changes, transitions and uncertainties, associated with significant risk of mental ill health in vulnerable individuals. Identity exploration and development is key during this phase, and the development of an eating disorder during this time can significantly impact on this process. This single-case study details the treatment of an 18-year-old female outpatient with first episode, recent onset anorexia nervosa. Using the Maudsley Model of Anorexia Nervosa Treatment in Adults (MANTRA), focus was placed on identity exploration and development as a tool to reduce the dominance of anorexia nervosa and increase recovery focus. Outcome measures at end of treatment and 6-month follow-up showed significant sustained improvement in BMI and EDE-Q scores. The patient gave detailed positive feedback suggesting that this was a highly acceptable and effective intervention. The case study is discussed with reference to limitations and some reflections on the utility of incorporating identity work in the treatment of anorexia nervosa in emerging adulthood.

Key learning aims

(1)

This case study is thought to have important clinical implications for tailoring the treatment of early stage AN to the emerging adult population.

(2)

Identity exploration is a key feature of this developmental stage, and incorporating this work into therapy allows for experimentation and formation of an alternative, healthy set of values, beliefs and behaviours.

(3)

This case also highlights the value of using role models in the construction of a non-illness driven identity, to support with behavioural change.
VARIETIES OF POSITIVE MODAL ALGEBRAS AND STRUCTURAL COMPLETENESS
Authors: MORASCHINI TOMMASO
Published: June 2019

Positive modal algebras are the$$\left\langle { \wedge , \vee ,\diamondsuit ,\square,0,1} \right\rangle $$-subreducts of modal algebras. We prove that the variety of positive S4-algebras is not locally finite. On the other hand, the free one-generated positive S4-algebra is shown to be finite. Moreover, we describe the bottom part of the lattice of varieties of positive S4-algebras. Building on this, we characterize (passively, hereditarily) structurally complete varieties of positive K4-algebras.
Why China finds it difficult to appreciate democracy
Authors: HUANG DAVID KC , LI NIGEL NT
Published: June 2019

This article explores the Chinese cognition of democracy in accordance with ancient Chinese political philosophy and modern constitutional jurisprudence. It argues that the classical Chinese cognition of democracy, i.e., demo-orientation, does not consist of any sense of equality and procedure, by which the Chinese people easily confuse democracy by the people with democracy for the people, thinking that China’s democracy subsists when the Chinese Government decides in favour of their interests. Moreover, the lack of sense of procedure produces inadequate means against tyranny, that the Chinese people can either admonish the ruler when he or she is still tolerable, or rebel when he or she is unbearable. Neither means serves institutionally.
The contents and contours of contemporary cosmopolitan constitution-making: Immanuel Kant in the twenty-first century
Authors: QERIMI QERIM
Published: June 2019

This article articulates legal and practical discourse that seek to apply and extend the classic cosmopolitan ideals of Immanuel Kant to the evolving practice and reality of the twenty-first century. It identifies five major strands through which cosmopolitan law ideals express themselves in contemporary constitution-making, forming in turn the major composite cosmopolitan contents. In some sense, the proposed framework re-imagines Kant in the twenty-first century, mirroring a conjoined classic and contemporaneous concept of cosmopolitan constitution-making. Kantian cosmopolitanism is reinterpreted by way of conjoining the classic cosmopolitan moral and normative principles of universal freedom, human worth and global justice to emerging and actual contemporaneous constitution-making trends such as using international or comparative foreign models as a basis for constitutional design, using international law and foreign domestic law in national constitutional interpretation, or using regional or international bodies of adjudication and their jurisprudence as a constitutionally mandated source of law. The outlined framework seeks to transcend the occasional historical setbacks and sceptical objections to cosmopolitanism, while admitting their continuous, albeit gradually unobtrusive presence. This framework is naturally predisposed to be deferential to a bold imaginative project, such as the one embodied in the Kantian vision of cosmopolitanism, which is both rooted in and survived the historical forces that ran contrary to the cosmopolitan ideals, to reach a point of its ever closer materialisation.
Leistungsbewertung im Skills Lab
Authors: Schlosser Daniela , Rebmann Marius
Published: June 2019

Zusammenfassung. Nachdem im ersten Teil die theoretischen Grundlagen zum Skills Lab Konzept sowie Ausführungen zur Identifikation von bildungshaltigen Lernsituationen erörtert wurden, spricht Teil 2 nicht nur die konkrete Umsetzung anhand eines Fallbeispiels an, sondern erläutert auch, welche Voraussetzungen geschaffen werden müssen, um eine gelungene pädagogische Diagnostik im Skills Lab zu verwirklichen.
Digitale Lernszenarien
Authors: Grosch Martina
Published: June 2019

Zusammenfassung. Die räumliche und zeitliche Flexibilität von Bildungsangeboten ist insbesondere in berufsbegleitenden Weiterbildungen und Studiengänge ein wichtiger Erfolgsfaktor. Blended Learning, also ein Wechsel aus Präsenzlehre und Selbstlernphasen in Form von E-Learning, wird in vielen Bildungseinrichtungen bereits erfolgreich umgesetzt. Wer jedoch noch einen Schritt weitergehen möchte und ganz auf digitale Lernformate setzt, sollte auch hier wichtige didaktische Grundüberlegungen nicht außer Acht lassen.
Kulturelle Barrieren syrischer Flüchtlinge bei der Aufnahme einer Pflegeausbildung – Eine qualitative Erhebung
Authors: Christa Kristina , Drossel Matthias , Sänger Sylvia
Published: June 2019

Zusammenfassung. Um dem Pflegefachkräftemangel zu begegnen werden seit einigen Jahren Pflegefachkräfte aus Staaten der europäischen Union rekrutiert. Dies ist jedoch nicht ausreichend, um den Bedarf zu decken. Aufgrund der Flüchtlingsproblematik stehen dem deutschen Arbeitsmarkt junge Menschen zur Verfügung, die eine Pflegeausbildung absolvieren können. Mithilfe einer Delphi-Befragung wurde untersucht, ob kulturelle Barrieren syrische Flüchtlinge daran hindern, eine Pflegeausbildung zu absolvieren.
Fading Air Pollution Reduces Fog in Central Valley
Authors: Sidder Aaron
Published: June 2019

The tule fog in California’s Central Valley is notorious for causing delays and accidents throughout the region; however, a decrease in air pollutants is reducing the fog’s frequency.
COMPASS for rapid combinatorial optimization of biochemical pathways based on artificial transcription factors
Authors: Naseri Gita , Behrend Jessica , Rieper Lisa , Mueller-Roeber Bernd
Published: June 2019

Balanced expression of multiple genes is central for establishing new biosynthetic pathways or multiprotein cellular complexes. Methods for efficient combinatorial assembly of regulatory sequences (promoters) and protein coding sequences are therefore highly wanted. Here, we report a high-throughput cloning method, called COMPASS for COMbinatorial Pathway ASSembly, for the balanced expression of multiple genes in Saccharomyces cerevisiae. COMPASS employs orthogonal, plant-derived artificial transcription factors (ATFs) and homologous recombination-based cloning for the generation of thousands of individual DNA constructs in parallel. The method relies on a positive selection of correctly assembled pathway variants from both, in vivo and in vitro cloning procedures. To decrease the turnaround time in genomic engineering, COMPASS is equipped with multi-locus CRISPR/Cas9-mediated modification capacity. We demonstrate the application of COMPASS by generating cell libraries producing β-carotene and co-producing β-ionone and biosensor-responsive naringenin. COMPASS will have many applications in synthetic biology projects that require gene expression balancing.
Isolated pairs of Majorana zero modes in a disordered superconducting lead monolayer
Authors: Ménard Gerbold C. , Mesaros Andrej , Brun Christophe , Debontridder François , Roditchev Dimitri , Simon Pascal , Cren Tristan
Published: June 2019

Majorana zero modes are fractional quantum excitations appearing in pairs, each pair being a building block for quantum computation. Some signatures of Majorana zero modes have been reported at endpoints of one-dimensional systems, which are however required to be extremely clean. An alternative are two-dimensional topological superconductors, such as the Pb/Co/Si(111) system shown recently to be immune to local disorder. Here, we use scanning tunneling spectroscopy to characterize a disordered superconducting monolayer of Pb coupled to underlying Co-Si magnetic islands. We show that pairs of zero modes are stabilized: one zero mode positioned in the middle of the magnetic domain and its partner extended all around the domain. The zero mode pair is remarkably robust, isolated within a hard superconducting gap. Our theoretical scenario supports the protected Majorana nature of this zero mode pair, highlighting the role of magnetic or spin-orbit coupling textures.