bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterizing Anchoring Bias in Vaccine Comparator Selection Due to Health Care Utilization With COVID-19 and Influenza: Observational Cohort Study
Authors: Ostropolets Anna , Ryan Patrick B , Schuemie Martijn J , Hripcsak George
Published: April 2022

Background

Observational data enables large-scale vaccine safety surveillance but requires careful evaluation of the potential sources of bias. One potential source of bias is the index date selection procedure for the unvaccinated cohort or unvaccinated comparison time (“anchoring”).

Objective

Here, we evaluated the different index date selection procedures for 2 vaccinations: COVID-19 and influenza.

Methods

For each vaccine, we extracted patient baseline characteristics on the index date and up to 450 days prior and then compared them to the characteristics of the unvaccinated patients indexed on (1) an arbitrary date or (2) a date of a visit. Additionally, we compared vaccinated patients indexed on the date of vaccination and the same patients indexed on a prior date or visit.

Results

COVID-19 vaccination and influenza vaccination differ drastically from each other in terms of the populations vaccinated and their status on the day of vaccination. When compared to indexing on a visit in the unvaccinated population, influenza vaccination had markedly higher covariate proportions, and COVID-19 vaccination had lower proportions of most covariates on the index date. In contrast, COVID-19 vaccination had similar covariate proportions when compared to an arbitrary date. These effects attenuated, but were still present, with a longer lookback period. The effect of day 0 was present even when the patients served as their own controls.

Conclusions

Patient baseline characteristics are sensitive to the choice of the index date. In vaccine safety studies, unexposed index event should represent vaccination settings. Study designs previously used to assess influenza vaccination must be reassessed for COVID-19 to account for a potentially healthier population and lack of medical activity on the day of vaccination.
Testing the Efficacy of Attitudinal Inoculation Videos to Enhance COVID-19 Vaccine Acceptance: Quasi-Experimental Intervention Trial
Authors: Piltch-Loeb Rachael , Su Max , Hughes Brian , Testa Marcia , Goldberg Beth , Braddock Kurt , Miller-Idriss Cynthia , Maturo Vanessa , Savoia Elena
Published: April 2022

Background

Over the course of the COVID-19 pandemic, a variety of COVID-19-related misinformation has spread and been amplified online. The spread of misinformation can influence COVID-19 beliefs and protective actions, including vaccine hesitancy. Belief in vaccine misinformation is associated with lower vaccination rates and higher vaccine resistance. Attitudinal inoculation is a preventative approach to combating misinformation and disinformation, which leverages the power of narrative, rhetoric, values, and emotion.

Objective

This study seeks to test inoculation messages in the form of short video messages to promote resistance against persuasion by COVID-19 vaccine misinformation.

Methods

We designed a series of 30-second inoculation videos and conducted a quasi-experimental study to test the use of attitudinal inoculation in a population of individuals who were unvaccinated (N=1991). The 3 intervention videos were distinguished by their script design, with intervention video 1 focusing on narrative/rhetorical (“Narrative”) presentation of information, intervention video 2 focusing on delivering a fact-based information (“Fact”), and intervention video 3 using a hybrid design (“Hybrid”). Analysis of covariance (ANCOVA) models were used to compare the main effect of the intervention on the 3 outcome variables: ability to recognize misinformation tactics (“Recognize”), willingness to share misinformation (“Share”), and willingness to take the COVID-19 vaccine (“Willingness”).

Results

There were significant effects across all 3 outcome variables comparing inoculation intervention groups to controls. For the Recognize outcome, the ability to recognize rhetorical strategies, there was a significant intervention group effect (P<.001). For the Share outcome, support for sharing the mis- and disinformation, the intervention group main effect was statistically significant (P=.02). For the Willingness outcome, there was a significant intervention group effect; intervention groups were more willing to get the COVID-19 vaccine compared to controls (P=.01).

Conclusions

Across all intervention groups, inoculated individuals showed greater resistance to misinformation than their noninoculated counterparts. Relative to those who were not inoculated, inoculated participants showed significantly greater ability to recognize and identify rhetorical strategies used in misinformation, were less likely to share false information, and had greater willingness to get the COVID-19 vaccine. Attitudinal inoculation delivered through short video messages should be tested in public health messaging campaigns to counter mis- and disinformation.
Representaciones sociales del medio ambiente
Authors: Calixto Flores Raúl
Published: April 2022

Las representaciones sociales (RS) corresponden a un tipo de conocimiento de las sociedades modernas, en el que las personas son consumidoras de ideas científicas ya formuladas. En educación ambiental existen RS de distintos tópicos, entre los que destacan los relacionados con el medio ambiente. En este artículo se describen algunos de los principales resultados obtenidos en una investigación respecto a las RS del medio ambiente en estudiantes de la Benemérita Escuela Nacional de Maestros de la ciudad de México. Entre los resultados destaca la caracterización de cinco tipos de RS del medio ambiente: antropocéntricas utilitaristas, pactuadas y culturales; naturalistas y globalizantes.
Research Paper on Detection and Prevention of Data Leakage
Authors: Gupta Dhiraj , Chellapandy Dr. Umarani
Published: April 2022

Abstract: A data distributor has given sensitive data to a group of supposedly trusted agents (third parties). Data are leaked and found in an unauthorized place or in the hands of an un authorized person. There must be an acknowledgement by the distributor that the information is compromised from one or more agents instead of being gathered independently. We suggest data allocation strategies that upgrade the likely hood of identifying leakages. These methods don't believe alterations of the released data. Keywords: data distributor, leaked data, data allocation, the guilty party
Study and Experimental Analysis on Bitumen
Authors: Adhav Prashant , Bhoir Akshay , Bhondiwale Ujwal , Chikane Aniket , Kamble Bhavesh , Mendhe Dr. Apeksha
Published: April 2022

Keywords: Bitumn, Modifier, Binders, Viscosity, Mixes, Tests
Design and Development of Road Cleaner Machine
Authors: Waghmare Atul , Singanjude Dhawal , Meshram Siddhant , Panchbhai Aniket , Talmale Manish , Umale Punam , Kamble Ruchika
Published: April 2022

Abstract: Cleaning is that the main basic want for all people at large and it's necessary for daily routine method. the traditional road improvement machine is most generally utilized in several applications like example roads, railway stations, airports, hospitals, Bus stands, in multi floor buildings, faculties etc. additionally this machine uses human energy for its operating operation. In our project we have a tendency to square measure aimed to use simply on the market materials with low value and it may be simply made-up and straightforward to use and management. It’s the higher different f or typical machine. Keywords: Eco friendly, Road Cleaner, Mechanically operated.
Hideout: The Socializing App
Authors: Sawant Adwait , Tichkule Rohit , Shetty Nihal
Published: April 2022

Abstract: Advances in communication technologies offer new opportunities for the conduct of qualitative research. Among these, Hideout—an innovative video conferencing platform—has a number of unique features that enhance its potential appeal to qualitative and mixed-methods researchers. Hideout has become nearly synonymous with office meetings and socializing as people around the world have adapted to life at home amid the coronavirus outbreak. That has put the roughly 9-year-old company in the spotlight more than ever before - for both the good and the bad, as an onslaught of security issues have come to light. As the coronavirus pandemic forced millions of people to stay home over the past month, Hideout suddenly became the video meeting service of choice. It encourages users to connect with friends and familyMany Cybersecurity research companies research says that it found security flaws in video conferencing platforms. While Hideout has addressed the issue, the report raises deeper concerns about the safety of video-conferencing apps that require access to microphones and cameras. Keywords: video conferencing, communication, community building.
Evaluation of the Nutritional Quality of Farmed Common Carp (Cyprinus carpio L.) Based on Fatty and Amino Acids Profile
Authors: Ahmed Arafat
Published: April 2022

The common carp (Cyprinus carpio) is the main species of carp being cultured in mid and southern Iraq. The consumer believes that the farmed fish is less nutritious than the wild fish, which affects its market value. The current study was designed to investigate the nutritional value of the common carp cultivated in the Basrah province based on the fatty and amino acid profile. Fatty acids were determined by Gas chromatography (GC), while an Amino Acid Analyzer was used for the determination of amino acids. The results revealed that the tested fish is rich in polyunsaturated fatty acids (especially essential omega-3 fatty acids), including α-linolenic acid (14.08±3.92%), docosahexaenoic acids (7.98 ±2.82 %), and eicosapentaenoic acid (2.81 ±0.34 %). Seven essential amino acids which are significant for the human body and the other ten non-essential amino acids were identified in the samples tested. Thus, it was established that the nutritional value of the farmed Cyprinus carpio is not less than the wild fish of the same species or family.
GROUNDS AND CONDITIONS FOR APPLICATION OF SUSPENSION OF SERVING A SENTENCE
Authors:   Южный федеральный университет, Ростов-на-Дону, Россия, Сусанна Григорьевна Саядян
Published: April 2022

The article is devoted to the issues of understanding such basic terms as the grounds and conditions for the postponement of serving a sentence. The text examines problematic issues related to the grounds and conditions for the postponement of serving a sentence, the features of legislative regulation that complicate the design and understanding of the content of Art. 82 of the Criminal Code of the Russian Federation. The author proposes to make some clarifying additions to the resolution of the Plenum of the Supreme Court of the Russian Federation.
AXIOLOGICAL FOUNDATIONS OF CONSERVATIVE LEGAL THINKING IN THE ERA OF DIGITAL TRANSFORMATION OF SOCIETY
Authors:   Южный федеральный университет, Ростов-на-Дону, Россия, Елена Александровна Казачанская
Published: April 2022

The article implements the conceptual and legal consideration of the concept of "conservatism", presents its author's interpretation, as well as the structural structure of conservatism as a social phenomenon. Special attention is paid to the consideration of such a specific type of manifestation of conservatism as conservative legal thinking and the main axiological characteristics of the latter are given. Separately, the paper analyzes the evolution of conservative legal thinking in the digital era of legal transformation, states, public-power institutions. The adequacy and effectiveness of the conservative approach to the formation of a comprehensive system of socioregulatory regulation of ambiguous processes of digital technology development is substantiated.
INFLUENCE OF DECISIONS OF THE CONSTITUTIONAL COURT OF THE RUSSIAN FEDERATION ON JUDICIAL PRACTICE IN THE SCOPE OF JUDICIAL REVIEW OF NORMATIVE ACTS
Authors:   Конституционный Суд Республики Ингушетия, Магас, Россия, Ильяс Муслимович Евлоев
Published: April 2022

The decisions of the Constitutional Court of the Russian Federation have a great influence on the formation of the law enforcement practice of other courts in the scope of judicial review of normative acts. So the positions of the Constitutional Court of Russia has changed understanding by courts of the procedural norms about accepting applications for challenging normative acts that have not been published. The judicial practice has also changed in terms of the assessment of applicant's interest at the stage of initiating a case. The article discusses the issue of any difficulties associated with adoption positions by the courts of general jurisdiction, of the reasons determines the wrong use of these decisions by courts, and also how such a reaction affects subsequent decisions of the Constitutional Court and the formation of more balanced practice.
ELECTRONIC PROTOCOL ON ADMINISTRATIVE OFFENSES IN THE ACTIVITIES OF INTERNAL AFFAIRS BODIES IN TRANSPORT
Authors:   Белгородский юридический институт МВД России имени И.Д. Путилина, Белгород, Россия, Анатолий Борисович Дудаев , Владимир Васильевич Ткаченко ,   Белгородский юридический институт МВД России имени И.Д. Путилина, Белгород, Россия, Владимир Васильевич Ткаченко ,   Белгородский юридический институт МВД России имени И.Д. Путилина, Белгород, Россия
Published: April 2022

The article discusses the issues of improving the proceedings on administrative offenses in the activities of internal affairs bodies in transport, taking into account the introduction of modern computer technologies in various spheres of life. Using the example of individual elements of offenses subordinated to the internal affairs bodies in transport, the authors propose drawing up a protocol on an administrative offense in the form of an electronic document, the protocol on an administrative offense is considered by the authors as the most important procedural document in which all signs of an offense are recorded. The procedure for drawing up an electronic protocol is proposed, subject to certain requirements. Special attention is paid to the electronic digital signature of the protocol, which ensures its evidentiary value and allows identifying the persons who signed the protocol. The authors made a reasonable proposal to amend Article 28.2 of the Administrative Code of the Russian Federation, regarding the electronic form of the protocol on an administrative offense.
THE PROBLEM OF VALUES IN CRIMINAL LAW
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Александр Иванович Бойко
Published: April 2022

The individual and social life of modern humanity is not limited to the satisfaction of material needs. The era of consumerism, where Russia has been plunged since the beginning of market reforms, confirms this axiom, the enormous importance of spiritual ideals. This article is about values in general and in the field of combating crime, in particular, their national and international basis, certification criteria, mechanisms of reflection in criminal legislation and industry doctrine. The idea is especially argued and emphasized that values hold the dormitory together, and therefore are rooted primarily in the most conservative areas of public consciousness - religion, morality, as well as in the hard-won provisions of world jurisprudence.
KEBIASAAN MAKANAN DAN REPRODUKSI IKAN LUNDU (Macrones gulio) DI PERAIRAN MAJAKERTA, INDRAMAYU, JAWA BARAT, INDONESIA
Authors: Sulistiono Sulistiono , A. M. Simanjuntak Johansen
Published: April 2022

Ikan lundu (Macrones gulio) merupakan salah satu ikan ekonomis penting dan banyak dimanfaatkan oleh masyarakat sebagai bahan pangan. Kajian mengenai aspek makanan dan reproduksi ikan lundu sebagai dasar dalam pengelolaan ikan tersebut masih sangat minim. Tujuan penelitian ini adalah mengkaji aspek kebiasaan makanan dan reproduksi ikan lundu yang mencakup jenis makanan, kelimpahan makanan, rasio kelamin, tingkat kematangan gonad, ukuran ikan pertama kali matang gonad, indeks kematangan gonad, fekunditas, dan diameter telur.  Penelitian dilakukan selama tiga bulan, pada Bulan Desember 2014 - Februari 2015. Total ikan contoh yang diamati (n= 201 ekor ikan), terdiri dari 98 ekor ikan jantan dan 103 ekor ikan betina.  Hasil penelitian menunjukkan bahwa ikan lundu termasuk ikan omnivora yang cenderung karnivora, dengan makanan utama berupa krustasea.  Rasio kelamin ikan jantan dan ikan betina 1:1,1.  Ikan betina lebih dahulu matang gonad dari pada ikan jantan. Fekunditas ikan lundu adalah 3100-24459 butir telur dengan modus penyebaran dua puncak yang mengindikasikan tipe pemijahan secara partial.
COVID-19 infection and nocardiosis causing the death of an adolescent with cystic fibrosis
Authors: S Driscoll , Carroll Will , S Nichani , R Fishwick , K Bakewell , Gilchrist Francis
Published: April 2022

To our knowledge this is the first published case of NP associated with
COVID-19 in an individual with CF and the first associated with
Nocardia infection. We suspect the combination of cystic
fibrosis, COVID-19 pneumonitis and co-infection with Nocardia
farcinia caused this young man’s NP and ultimately his untimely death.
We hope this case will highlight individuals with CF of all ages are at
risk of severe COVID-19 infection.
The effect of Rifampin on the Pharmacokinetics of Famitinib in Healthy Subjects
Authors: Li Ting , Li Xin , Jiang Xin , Wang Chenjing , Sun Feifei , Liu Yanping , Lin Pingping , Shi Ping , Fu Yao , Gao Xiaomeng , Cao Yu
Published: April 2022

Background Famitinib is an oral, small-molecule, multi-targeted tyrosine
kinase inhibitor under clinical investigation for the treatment of solid
tumors. As famitinib is metabolized mainly by cytochrome P450 3A4
(CYP3A4), the study was conducted to investigate the effect of potent
CYP3A4 inducer rifampin on the pharmacokinetics of famitinb. Methods
This single-center, single-arm and fixed-sequence drug-drug interaction
study enrolled 21 healthy Chinese male subjects. Subjects received a
single oral dose of famitinib 25 mg on days 1 and 16 and repeated
administration of oral rifampin 600mg once daily on days 10-23. Blood
samples were collected and plasma concentrations of famitinib were
measured by validated liquid chromatography-tandem mass spectrometry
(LC-MS/MS) method. Pharmacokinetic parameters were calculated using
noncompartmental analysis and safety was assessed. Results In the
presence of rifampin, the famitinib geometric mean maximum plasma
concentration (Cmax) and area under the plasma concentration-time curve
from time zero to infinity (AUC0-∞) decreased by 48% and 69%,
respectively, and the mean elimination half-life was shortened from 33.9
h to 18.2 h. The GMR of famitinib Cmax and AUC0-∞ and their 90% CI were
0.52 (0.50, 0.54) and 0.31 (0.29, 0.33). Single dose of famitinib 25mg
was well tolerated and 8 subjects (38.1%) reported treatment emergent
adverse events. Conclusion Co-administration of rifampin considerably
reduces plasma concentration of famitinb due to CYP3A4 induction.
Concomitant administration of famitinib and strong CYP3A4 inducers
should be avoided, whereas when simultaneous use with inducers of
CYP3A4, dose adjustment of famitinb is recommended.
Colonic cryptococcosis presenting with chronic diarrhea in a person with advanced human immunodeficiency virus disease: a case report
Authors: Oh Hyunjoo , Kim Misun , Yoo Jeong Rae , Boo Sun-Jin , Heo Sang Taek
Published: April 2022

Cryptococcus neoformans infection usually occurs in patients with advanced human immunodeficiency virus (HIV) infection or with a CD4 T lymphocyte count of <100 cells/μL. Pulmonary and central nervous system infections are the most frequently encountered forms of cryptococcosis; however, colonic cryptococcosis is uncommon. We describe the case of a 41-year-old antiretroviral-naïve man with HIV infection diagnosed eight years prior and intermittent diarrhea for 4 months who presented to the emergency department with a 1-day history of low-grade fever and confusion. Brain magnetic resonance imaging and cerebrospinal fluid analysis revealed normal results; however, he was diagnosed with Pneumocystis jirovecii pneumonia based on chest computed tomography and bronchoalveolar lavage analysis. Trimethoprim-sulfamethoxazole administration was initiated followed by antiretroviral treatment. Although his condition gradually improved, he developed fever and abdominal discomfort, and the diarrhea worsened. Endoscopy revealed a small ulcer in the distal transverse colon. Histopathological examination of a colon tissue sample revealed cryptococcal infection. He improved substantially during liposomal amphotericin B and fluconazole treatment. We encountered a rare case of colonic cryptococcosis that caused chronic diarrhea in a patient with advanced HIV infection. Colonic cryptococcosis should be considered when patients with acquired immune deficiency syndrome present with gastrointestinal symptoms.
Plant histone modifications in response to cold stress
Authors: Hyun Tae
Published: April 2022

Cold stress is a major environmental factor limiting agricultural expansion
and crop yields, and plants have developed diverse molecular mechanisms to
cope with a lifetime of exposure to cold stress. Histone modifications play
a fundamental role in regulating chromatin dynamics and transcriptional
activation, either directly or through protein adaptors termed effectors.
Growing evidence indicates that the chromatin remodeling caused by histone
modifications, including acetylation, methylation, phosphorylation, and
ubiquitination, is required for stress-responsive transcription, stress
adaptation, and stress memory in plants. In this mini-review, I have
summarized the current knowledge regarding the histone modifications
associated with plant responses to cold stress, and discussed the roles of
these modifications in improving plant cold tolerance.
The epiphytic bryophyte succession of Picea orientalis forests on the Kumbet High Plateau (Giresun-Turkey)
Authors: Ezer Tülay , Alataş Mevlüt , Batan Nevzat , Erata Hüseyin
Published: April 2022

In this study, the epiphytic bryophyte succession of Picea orientalis forests on the K?mbet High Plateau (Giresun-Turkey) were studied. A total of 21 epiphytic bryophyte species were determined (16 mosses and 5 liverworts). The epiphytic bryophyte communities were sampled in 60 sample plots taken from the trunks of Picea orientalis, each of which was 20 ? 20 cm in size. The Index of Ecological Significance (IES), based on a combination of the relative frequency and mean cover of epiphytic bryophytes, was used to evaluate the abundance of bryophyte communities in epiphytic habitats on the tree trunks. In addition, multivariate classification techniques (TWINSPAN and DECORANA) were used to classify the community structures in successional stages. TWINSPAN divided the 60 sample plots into two main groups: a) the lower base communities (LB) and b) the middleupper zone communities (MU). Moreover, the middle-upper zone communities (MU) were divided into two sub-groups associated with the successional gradient (MU1 and MU2). DECORANA classified these communities along the ordination axes 1 and 3 related to the height gradient of Picea orientalis and the moisture (from mesic to xeric) gradient of the epiphytic habitat. While Exsertotheca crispa, Cynodontium fallax, Lewinskya striata, and Habrodon perpusillus were only found on old spruce trees, Drepanium fastigiatum was only found on young trees and Lophocolea heterophylla was only found on middle-aged trees.
Aspicilia nigromaculata sp. nov. (Megasporaceae, Pertusariales, Ascomycota) from Azad Jammu and Kashmir, Pakistan, evidence from morphology and DNA sequencing data
Authors: Fayyaz Iram , Afshan Najam , Niazi Abdul , Khalid Abdul
Published: April 2022

A new species of Megasporaceae, Aspicilia nigromaculata sp. nov. is described
and illustrated from Pakistan. A comparative morpho-anatomical study and
ITS- LSU-based molecular analyses confirmed its position within the genus
Aspicilia. It differs from the other species of the genus by the following
set of features: a well-developed, grey to greenish grey frequently black
spotted thick thallus, well- developed thicker peripheral and flat to
slightly concave areoles, and small conidia 10-15 ? 0.5-1 ?m. Its
positioning in a separate branch in the phylogenetic tree also makes it
distinct from the other known species of the genus.
Plastic Surgery Considerations for the General Surgeon
Authors: Agnew Sonya P , Dumanian Gregory A.
Published: April 2022

Plastic surgery does not claim a specific region of the body, a tissue type, a disease process, or a technique. Instead, plastic surgery holds central to its core the concepts of tissue perfusion and tissue rearrangement to restore function and appearance. Rather than being at the fringes of medicine and surgery, mastery of these issues allows the plastic surgeon to become a generalist and consultant to all of the surgical disciplines. Reconstructive surgery, wound healing, tissue perfusion, and vascularity are the general themes first discussed by the authors. Plastic surgery considerations for surgery of the abdomen, the breast, and the soft tissues are then covered in order, with all relevant procedures described. The authors discuss scar revisions and the principles of wound closure that favorably impact the final appearance in their conclusion. 
This review contains 5 figures, 9 tables and 15 references
Keywords: Plastic surgery, reconstructive surgery, tissue perfusion, wound healing, panniculectomy, mammaplasty, omental flap, scar revision
GLP-2 Regulation of Dietary Fat Absorption and Intestinal Chylomicron Production via Neuronal Nitric Oxide Synthase (nNOS) Signaling
Authors: Grande Elisabeth M. , Raka Fitore , Hoffman Simon , Adeli Khosrow
Published: April 2022

Postprandial dyslipidemia is a metabolic condition commonly associated with insulin-resistant states, such as obesity and type 2 diabetes (T2D). It is characterized by the overproduction of intestinal chylomicron particles and excess atherogenic chylomicron remnants in circulation. We have previously shown that glucagon-like peptide-2 (GLP-2) augments dietary fat uptake and chylomicron production in insulin-resistant states; however, the underlying mechanisms remain unclear. Previous studies have implicated nitric oxide (NO) in the absorptive actions of GLP-2. Here, we report a novel role for neuronal NO synthase (nNOS)-mediated NO generation in lipid uptake and chylomicron formation based on studies in C57BL/6J mice, nNOS-/- mice, and Syrian golden hamsters, after intraduodenal and oral fat administration. GLP-2 treatment in WT mice significantly increased postprandial lipid accumulation and circulating apolipoprotein B48 protein levels, while these effects were abolished in nNOS-/- mice. nNOS inhibition in Syrian golden hamsters and PKG inhibition in WT mice also abrogated the effect of GLP-2 on postprandial lipid accumulation. These studies demonstrate a novel mechanism in which nNOS-generated NO is crucial for GLP-2-mediated lipid absorption and chylomicron production in both mouse and hamster models. Overall, our data implicates an nNOS-PKG mediated pathway in GLP-2-mediated stimulation of dietary fat absorption and intestinal chylomicron production. 
Footprints of interaction among Finniс-speaking, Slavic, and Turkic-speaking populations in modern gene pool and their reflection in pharmacogenetics
Authors: Balanovska EV , Gorin IO , Ponomarev GYu , Pylev VYu , Petrushenko VS , Markina NV , Mamaeva AD , Larin AK , Agdzhoyan AT
Published: April 2022

Genetic contribution of pre-Slavic populations to gene pools of modern Russia is increasingly relevant, along with genetic footprints of the Golden Horde invasion. The novel genome-wide approaches enable advanced solutions in this field. The study aimed at searching for the footprints of genetic interaction among Finnicspeaking, Slavic and Turkic-speaking populations of Central Russia and Volga Region and their reflection in pharmacogenetic landscape. Modeling ancestral components by ADMIXTURE software and their mapping involved genome-wide genotyping data for 248 individual genomes representing 47 populations of 9 ethnic groups. Of specific ancestral components identified in each of the Finnic-speaking peoples, only Mordovian ancestral components are common for all populations within the studied geographic area, regardless of their linguistic affiliation. Gene pools of Russian populations include 80% of intrinsic component, 19% contribution from Finnic-speaking peoples, and 1% of Central Asian influence. The Tatar gene pool combines all identified ancestral components, including 81% contribution from Finnic-speaking peoples and only 12% of Central Asian influence, which prevents using it as a reference for the assessment of Golden Horde footprints in Russian gene pools. A map of genetic distances from Ryazan Russians based on a panel of 42 pharmacogenetic markers reveals a landscape strikingly independent from the selectively neutral ancestral genomic patterns. For instance, populations of Mordovia, Kaluga, Smolensk, and Kostroma regions are the closest to Ryazan Russians in pharmacogenetic status, whereas populations of Ryazan and Nizhny Novgorod regions have strikingly divergent pharmacogenetic status despite the similarity of the selectively neutral ancestral genomic patterns. These findings confirm the relevance of targeted pharmacogenetic characterization for gene pools of Russia.
Energy security as an integral element of ensuring the economic security of the state in the national security strategies of Ukraine
Authors: Shevchenko O.
Published: April 2022

The article reveals the evolution of energy security in Ukraine's national security strategies during the years of independence. It is determined that a number of issues related to the creation of the most effective system of energy security of the state support within the existing National Security Strategies of Ukraine at various stages of state formation remain unresolved, both at the legislative level and in the functioning of relevant competent state bodies.

The content of ensuring the energy security of the state in the four national security strategies of Ukraine is revealed. It is determined that the issue of ensuring energy security of the state requires a clear definition of the state in strategic priorities and goals that should correspond to current trends in the national economy and world realities in this area.

It was emphasized that in accordance with the Final Provisions of the National Security Strategy 2020 on the development of planning documents in the field of national security and defense, which will determine the ways and tools of its implementation, the Cabinet of Ministers of Ukraine on August 4, 2021 approved the Energy Security Strategy. Ukraine, which defines the target model of the energy security system as a component of national security.

It is emphasized that the Energy Security Strategy of Ukraine identifies 29 key threats to energy security. These include, in particular, external risks - cyber threats to critical energy infrastructure, aggression by the Russian Federation, and internal - possible failure to integrate with EU electricity and gas supply systems, depreciation of fixed assets, lack of energy reserves and more.

It is noted that the strategic approach is extremely important for such a complex sector of the economy as energy. Given the unstable situation in the geopolitical sphere, given the limited energy resources and the need to develop ecologically and with concern for the environment, we need to understand all the potential risks and threats that may affect the Ukrainian energy sector. That is why the Energy Security Strategy of Ukraine is necessary to ensure predictability of development and sustainability of the energy system, timely identification of threats and prevention.

Threats to national security in the field of energy security have been studied. It is emphasized that currently the most correct and meaningful definition of energy security is the definition, which is enshrined in the newly approved Energy Security Strategy of Ukraine. Thus, energy security is the protection of national interests in ensuring access to reliable, sustainable, affordable and modern energy sources in a technically reliable, safe, cost-effective and environmentally friendly way under normal conditions and in conditions of special or emergency conditions.

The directions of increase of efficiency of maintenance of energy security of Ukraine are defined.
Space of the Northern Sea Route: ecology and safety
Authors: Novozhilov A. M.
Published: April 2022

Today the Northern Sea Route is an international trade route, a space for the movement of freight traffic between the markets of the Pacific and Atlantic oceans. The growth of traffic along the Northern Sea Route is associated, among other things, with climate change and global warming, which has been going on for several decades. Researchers note the possible negative and positive consequences of the global warming process for the economy and the environment. Russia plays a leading role in ensuring the security of the Northern Sea Route and reliable and effective control over sea spaces and coastlines.
COMBINED MÖSSBAUER SPECTROMETRY AND ATOM PROBE TOMOGRAPHY INVESTIGATION OF MECHANICALLY MILLED RARE EARTH / TRANSITION METAL POWDERS
Authors: LE BRETON Jean-Marie , LARDE Rodrigue , ABOU LATIF Amjaad , MAAT Nicolas MAAT , NACHBAUR Virginie , ISNARD Olivier , GIVORD Dominique , CHICINAȘ Ionel , POP Viorel
Published: April 2022

The microstructure of mechanically milled Nd2Fe14B, SmCo5/Fe and SmCo3Cu2/α-Fe alloys has been investigated by Mössbauer spectrometry and atom probe tomography. The structural changes that occur upon milling and subsequent annealing were characterised at a nanometer scale. Milling promotes intermixing of the elements and the formation of nanograins. In Nd-Fe-B powders, the Nd2Fe14B phase is transformed into α-Fe and an amorphous Nd-Fe-B phase. In SmCo5/Fe powders, Fe/Co intermixing occurs, leading to the formation of Sm(Co,Fe)5 and α-Fe(Co) phases. In SmCo3Cu2/Fe powders, although Sm is partly oxidised, Fe/Co intermixing occurs as well, leading to the formation of α-Fe(Co) nanograins surrounded by Sm(Co,Cu,Fe)5 intergranular regions. The combined Mössbauer and atom probe tomography investigation of rare earth / transition metal powders thus allows revealing the effect of mechanical milling and subsequent annealing on the nanostructure of the powders. These results are helpful for the understanding of the magnetic properties of the powders.
THE EFFECT OF ALKALI AND SURFACTANT CONCENTRATION, TEMPERATURE AND STIRRING ON THE CLEANING EFFICIENCY OF THE CARBON STEEL SURFACE
Authors: MIHIS A. , DANCIU V. , SALAGEAN C.A. , SZÉKELY I. , RACOLTA-PAINA M.V. , TRIPON S.C. , COTET L.C. , MAGYARI K. , BAIA L.
Published: April 2022

Electrostatic painting is the fastest and most efficient technology through industrial paints due to its impact on the environment, and also for its very easy application on different surfaces. The first and most important stage of the electrostatic painting is to clean the surface to be painted by removing the dirt, lubricants, oils, metal oxides or welding residues. In order to increase the efficiency of carbon steel surface cleaning, the influence of alkali and surfactant concentrations, temperature and stirring was investigated. To produce a uniform surface required for the electrostatic painting, some degreased samples were subjected to pickling operation using aqueous HCl solution.
Variación temporal de nitro-HAPs asociados a partículas PM2.5 en la atmosfera de las ciudades de Cuernavaca y Cuautla
Authors:   , Álvarez Lupercio Zuleica Tamara
Published: April 2022

Due to the damage they cause to the health of the population as a result of their composition, PM2.5 is a very important indicator of air quality in urban areas. Some polycyclic aromatic nitro-hydrocarbons (nitro-PAHs) associated with the particles have been observed to be mutagenic and carcinogenic. In order to observe the variation of the concentration at different times of the year, the nitro-HAPs in PM2.5 emitted in the city of Cuernavaca during the period from March 2016 to August 2018 and for Cuautla during the period of April 2017 to December 2018. It is reported that the lowest concentration of nitro-PAHs occurred in the rainy season (LL), with a median of 63.82 pg / m-3 for Cuernavaca and 90.67 pg / m-3 for Cuautla. It was hypothesized that Cuernavaca during the dry-cold season (SF) was the one with the highest concentration of nitro-PAHs, however, no significant difference was found (p <0.05) with respect to the dry-hot season (SC). The median concentrations in the SC and Seseasons were 116.41 pg m-3 and 128.99 pg m-3, respectively. However, in Cuautla significant differences (p <0.05) were observed between the SF and SC periods. Median concentrations for SC were 280.74 pg m-3 and for SF 156.61 pg m-3. 1-Nitronaphthalene, 2-Nitrofentranene, 2-Nitroanthracene, and 2-Nitrofluoranthene were the most abundant compounds present at both sites. Nitro-HaPs showed significant correlations (p <0.05) with relative humidity and wind speed, as well as with some criteria pollutants. 1-Nitronaphthalene, 2-Nitronaphthalene, 2-Nitrofluorene, and 3-Nitrofluoren are classified by IARC as possible carcinogens for humans, these compounds were found in the three seasons in the cities of Cuernavaca and Cuautla.
El discurso histórico en el noticiario fílmico Cine verdad, 1953-1973
Authors:   , Barbosa Vargas Alexis
Published: April 2022

Este estudio se basa en dos elementos fundamentales de Cine Verdad: sus condiciones periodísticas y cinematográficas. Con estos dos enfoques podremos establecer la especificidad de este noticiario y, por ende, delimitar y establecer ciertas categorías de análisis para el estudio de caso que son estas diez cápsulas de Cine Verdad. Estas cápsulas se realizaron a finales de los años cincuenta y principios de los sesenta en medio de la Revolución cubana y el cincuentenario de la Revolución mexicana. Por lo tanto, el énfasis de la investigación está en estos años, aunque al no haber una investigación previa, resulta imprescindible hablar de este noticiario de una manera genérica, sobre todo en los dos primeros capítulos. De este modo, el primer capítulo se centra en la condición cinematográfica de Cine Verdad, mientras que el segundo capítulo parte de la condición periodística del noticiario. Ambos capítulos parten de las siguientes preguntas: ¿Cuál es la especificidad de Cine Verdad respecto a otros formatos impresos como los periódicos o las revistas y también audiovisuales como los documentales y los noticiarios de cine y televisión? ¿Quiénes son las personas detrás del noticiario y cuáles son sus intereses políticos y económicos? y ¿Cuáles son los géneros y formatos privilegiados dentro de Cine Verdad? Finalmente, en el último capítulo se analizan las cápsulas sobre historia en Cine Verdad con base en categorías de los dos primeros capítulos como estilo, nacionalismo y realismo, así como las categorías historiográficas de tiempo, espacio y sujetos. Con estas cápsulas de breve duración se analiza la manera en que este noticiario representaba el pasado a partir del presente y con miras al futuro. Por último, se reflexiona sobre la relación de la difusión, la divulgación y la didáctica con estas formas de representar el pasado.
Nociones de lo moderno en la historiografía cultural de la arquitectura del siglo XX. La obra escrita de Carlos Obregón Santacilia
Authors:   , Cebey Montes de Oca Georgina
Published: April 2022

Las ideas sobre la arquitectura del siglo XX mexicano han sido expresadas con una claridad apreciable en las propias edificaciones que, al mismo tiempo, han sintetizado el prolífico desarrollo de la cultura arquitectónica de México. Sin embargo, esa arquitectura es el símbolo de toda una ideología, ella es sólo el sustento material -casi testimonial— del despliegue de una serie de circunstancias sociales, políticas y culturales. Ese conglomerado intelectual, el sustento ideológico de la arquitectura, dio forma a la historia de la arquitectura de la modernidad mexicana. Esa historia es el tema de esta tesis, una escritura realizada por los propios arquitectos con características en suma peculiares. Dicha historia que cobra sentido en la obra escrita y construida del arquitecto Carlos Obregón Santacilia (Ciudad de México, 1896-1961), es el objeto de estudio de este trabajo.
Spring barley response to tillage systems and crop residues
Authors: Woźniak Andrzej , Rachoń Leszek
Published: April 2022

The present study aimed to assess the effect of tillage systems and crop residues on grain yield and weed infestation of spring barley. The experiment was established with the method of randomized sub-blocks. The main experimental factor was the tillage system (TS): conventional tillage (CT), reduced tillage (RT), and no-tillage (NT). The second experimental factor included plots with crop residues (CR): straw (S) or without straw (WS). A higher grain yield of barley was determined in the RT than NT system. The RT system allowed producing a higher spike number and a higher 1000 grain weight. A higher grain yield was also obtained on the plots with straw (S) than without straw (WS). Greater weed density in barley stands was determined on RT and NT plots without crop residues (WS), whereas the lowest one was found on the CT plots with the residues (S). The air-dry weight of weeds was higher on the NT plots without crop residues (WS) than on the other plots, while the lowest air-dry weight of weeds was determined on the CT plots with the residues (S). The biodiversity of weeds in a barley stand was greater on the WS than on the S plots.
STRATEGI PUSKESMAS TABANAN I DALAM PELAKSANAAN POSYANDU BALITA SEBAGAI UPAYA PEMANTAUAN STATUS GIZI BALITA PADA MASA PANDEMI COVID-19
Authors: Dewi I Dewa Ayu Bintang Pradnya , Kurniati Desak Putu Yuli
Published: April 2022

Toddlers are vulnerable groups infected with COVID-19. Monitoring the nutritional status of toddlers through Posyandu Balita is very important to ensure the growth and development of toddlers is not disturbed. During the COVID-19 pandemic, monitoring the nutritional status of toddlers did not run optimally. This study aims to find out the strategy of Puskesmas Tabanan I in the implementation of Posyandu Balita as an effort to monitor the nutritional status of toddlers during the COVID-19 pandemic. The research design used is qualitative descriptive research. The research informant consisted of Tabanan I Puskesmas Officer, Village Midwife, Posyandu Cadre, Village Head and Toddler Mother. Data collection techniques with in-depth interviews and observations. This research was conducted during April to May 2021. Data analysis uses thematic analysis and data validation strategies using source triangulation, method triangulation and peer debriefing. The results showed that strategy of implementing Posyandu Balita was conducted with a home visit to monitor the growth of toddlers. Online media as a tools to dissemination of information about health of toddlers and the implementation of health protocols. Training to improve skills is needed in the development of the implementation strategy of Posyandu Balita during the COVID-19 pandemic.

Keywords: Toodlers Posyandu, COVID-19, monitoring the nutritional status of toodlers, implementation strategies, Community Health Center
ANALISIS TINGKAT KEPUASAN MASYARAKAT TERHADAP MUTU PELAYANAN PUBLIK PADA MASA PANDEMI COVID-19 DI KANTOR BPJS KESEHATAN KABUPATEN BADUNG
Authors: Putri Ayuning Sekar , Listyowati Rina
Published: April 2022

The social restriction policy due to the COVID-19 pandemic has had an impact on the delay of various public services, one of which is BPJS Health services. In the midst of a pandemic situation, BPJS Kesehatan is required to provide quality services to the community. Therefore, this study aims to determine the level of community satisfaction in terms of five dimensions of service quality, namely Responsiveness, Reliability, Assurance, Empathy, and Tangible. This study uses a quantitative design with a cross-sectional approach. The sample of this study was 100 people who visited the service office, with the sampling technique using the consecutive sampling method. The results of the univariate analysis show the characteristics of the respondents at the BPJS Kesehatan. The majority of respondents are aged between 26 years and 50 years (62.00%), male and female gender are the same (50.00%), bachelor degree (40.00%), working status Private Employee (49.00%), and domiciled from Mengwi District (29.00%). Bivariate analysis using the Chi-square test found that there was a significant relationship between the five dimensions of service quality and community satisfaction (p-value < 0.001). Most respondents are dissatisfied with the services provided at the BPJS Health Office in Badung Regency, so BPJS needs to pay attention to several dimensions that are still not satisfied by respondents, such as the Tangible aspect, so that the quality of service to the community can continue to be improved during the COVID-19 pandemic.

Key words: Community Satisfaction, Public Services, COVID-19 Pandemic
BISPESIFIK IL-17A DAN IL-17F (IL-17A/F) SEBAGAI INOVASI TERAPI TERBARU BAGI PARA PENDERITA PSORIASIS: SEBUAH TELAAH PUSTAKA SISTEMATIS
Authors: Kuatama Rexel , Ruby Rivaldi , Mangkuliguna Ghea
Published: April 2022

Introduction: Psoriasis is a chronic inflammatory skin disease characterized with redness, scaling, induration, itchiness, and thickness of skin that worsen quality of life, particularly in moderate to severe psoriatic patients. Although the emergence of biologics has provided revolutionary therapy in the management of moderate to severe psoriasis, significant number of patient has shown ineffectiveness. Recent studies suggest the use of bispecific antibodies as an effective and efficient alternatives . This review aims to evaluate the effectiveness and adverse side effects of bispecific IL-17A/F in various clinical studies. Discussion: This paper yields results that ~100% and >80% of patients treated with bispecific IL-17A/F is able to achieve PASI75 and PASI90, respectively, by week 12 in phase I and II studies. Moreover, bispecific IL-17A/F is able to significantly reduce inflammatory response in psoriatic skin biopsies. Only mild treatment-related adverse events is reported and no immunogenicity is detected. Conclusion: Bispecific IL-17A/F provides effective therapy with minimal adverse side effects within a short amount of time. Further study is needed to compare its effectiveness against other biologics.   

Keywords: bimekizumab, biologics, bispecific IL17A/F, M1095, psoriasis, systematic review