bluuebunny/crossref_metadata_2025 huggingface dataset:
Molybdenum systematics of subducted crust record reactive fluid flow from underlying slab serpentine dehydration
Authors: Chen Shuo , Hin Remco C. , John Timm , Brooker Richard , Bryan Ben , Niu Yaoling , Elliott Tim
Published: October 2019

Fluids liberated from subducting slabs are critical in global geochemical cycles. We investigate the behaviour of Mo during slab dehydration using two suites of exhumed fragments of subducted, oceanic lithosphere. Our samples display a positive correlation of δ98/95MoNIST 3134 with Mo/Ce, from compositions close to typical mantle (−0.2‰ and 0.03, respectively) to very low values of both δ98/95MoNIST 3134 (−1‰) and Mo/Ce (0.002). Together with new, experimental data, we show that molybdenum isotopic fractionation is driven by preference of heavier Mo isotopes for a fluid phase over rutile, the dominant mineral host of Mo in eclogites. Moreover, the strongly perturbed δ98/95MoNIST 3134 and Mo/Ce of our samples requires that they experienced a large flux of oxidised fluid. This is consistent with channelised, reactive fluid flow through the subducted crust, following dehydration of the underlying, serpentinised slab mantle. The high δ98/95MoNIST 3134 of some arc lavas is the complement to this process.
The FluPRINT dataset, a multidimensional analysis of the influenza vaccine imprint on the immune system
Authors: Tomic Adriana , Tomic Ivan , Dekker Cornelia L. , Maecker Holden T. , Davis Mark M.
Published: October 2019

Machine learning has the potential to identify novel biological factors underlying successful antibody responses to influenza vaccines. The first attempts have revealed a high level of complexity in establishing influenza immunity, and many different cellular and molecular components are involved. Of note is that the previously identified correlates of protection fail to account for the majority of individual responses across different age groups and influenza seasons. Challenges remain from the small sample sizes in most studies and from often limited data sets, such as transcriptomic data. Here we report the creation of a unified database, FluPRINT, to enable large-scale studies exploring the cellular and molecular underpinnings of successful antibody responses to influenza vaccines. Over 3,000 parameters were considered, including serological responses to influenza strains, serum cytokines, cell phenotypes, and cytokine stimulations. FluPRINT, facilitates the application of machine learning algorithms for data mining. The data are publicly available and represent a resource to uncover new markers and mechanisms that are important for influenza vaccine immunogenicity.
Radiomics Nomogram Analyses for Differentiating Pneumonia and Acute Paraquat Lung Injury
Authors: Yanling Wang , Duo Gao , Zuojun Geng , Zhongqiang Shi , Yankai Wu , Shan Lu , Hongying Cui
Published: October 2019

Paraquat poisoning has become a serious public health problem in some Asian countries because of misuse or suicide. We sought to develop and validate a radiomics nomogram incorporating radiomics signature and laboratory bio-markers, for differentiating bacterial pneumonia and acute paraquat lung injury. 180 patients with pneumonia and acute paraquat who underwent CT examinations between December 2014 and October 2017 were retrospectively evaluated for testing and validation. Clinical information including demographic data, clinical symptoms and laboratory test were also recorded. A prediction model was built by using backward logistic regression and presented on a nomogram. The radiomics-based features yielded areas under the receiver operating characteristic curve of 0.870 (95% CI 0.757–0.894), sensitivity of 0.857, specificity of 0.804, positive predictive value of 83.3%, negative predictive value of 0.818 in the primary cohort, while in the validation cohort the model showed similar results (0.865 (95% CI 0.686–0.907), 0.833, 0.792, 81.5%, respectively). The individualized nomogram included radiomics signature, body temperature, nausea and vomiting, and aspartate transaminase. We have developed a radiomics nomogram that combination of the radiomics features and clinical risk factors to differentiate paraquat lung injury and pneumonia for patients with an unclear medical history of exposure to paraquat poisoning, providing appropriate therapy decision support.
Denoising of Aligned Genomic Data
Authors: Fischer-Hwang Irena , Ochoa Idoia , Weissman Tsachy , Hernaez Mikel
Published: October 2019

Noise in genomic sequencing data is known to have effects on various stages of genomic data analysis pipelines. Variant identification is an important step of many of these pipelines, and is increasingly being used in clinical settings to aid medical practices. We propose a denoising method, dubbed SAMDUDE, which operates on aligned genomic data in order to improve variant calling performance. Denoising human data with SAMDUDE resulted in improved variant identification in both individual chromosome as well as whole genome sequencing (WGS) data sets. In the WGS data set, denoising led to identification of almost 2,000 additional true variants, and elimination of over 1,500 erroneously identified variants. In contrast, we found that denoising with other state-of-the-art denoisers significantly worsens variant calling performance. SAMDUDE is written in Python and is freely available at https://github.com/ihwang/SAMDUDE.
Zeolite RHO Synthesis Accelerated by Ultrasonic Irradiation Treatment
Authors: Ng Tiffany Yit Siew , Chew Thiam Leng , Yeong Yin Fong , Jawad Zeinab Abbas , Ho Chii-Dong
Published: October 2019

In recent years, there are increasing interest on applying ultrasonic irradiation for the synthesis of zeolite due to its advantages including remarkable shortened synthesis duration. In this project, the potential of ultrasonic irradiation treatment on the synthesis of zeolite RHO was investigated. Ultrasonic irradiation treatment time was varied from 30 to 120 minutes for the synthesis of zeolite RHO. The zeolite RHO solid samples were characterized with X-ray Diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA) and nitrogen adsorption-desorption analysis. The application of ultrasonic irradiation treatment in this study has accelerated the synthesis of zeolite RHO where the synthesis duration has been significantly shortened to 2 days compared to 8 days required by conventional hydrothermal heating without ultrasonic irradiation treatment. Highly crystalline zeolite RHO crystals in truncated octahedron morphology were successfully formed.
The Effect of Surface Roughness on the Contact Line and Splashing Dynamics of Impacting Droplets
Authors: Quetzeri-Santiago Miguel A. , Castrejón-Pita Alfonso A. , Castrejón-Pita J. Rafael
Published: October 2019

Whether a droplet splashes upon impact onto a solid is known to depend not only on the fluid properties and its speed, but also on the substrate characteristics. Past research has shown that splashing is heavily influenced by the substrate roughness. Indeed, in this manuscript, we demonstrate that splashing is ruled by the surface roughness, the splashing ratio, and the dynamic contact angle. Experiments consist of water and ethanol droplets impacting onto solid substrates with varying degrees of roughness. High speed imaging is used to extract the dynamic contact angle as a function of the spreading speed for these impacting droplets. During the spreading phase, the dynamic contact angle achieves an asymptotic maximum value, which depends on the substrate roughness and the liquid properties. We found that this maximum dynamic contact angle, together with the liquid properties, the ratio of the peak to peak roughness and the surface feature mean width, determines the splashing to no-splashing threshold. In addition, these parameters consistently differentiate the splashing behaviour of impacts onto smooth hydrophilic, hydrophobic and superhydrophobic surfaces.
Mitochondrial dysfunction increases pro-inflammatory cytokine production and impairs repair and corticosteroid responsiveness in lung epithelium
Authors: Hoffmann R. F. , Jonker M. R. , Brandenburg S. M. , de Bruin H. G. , ten Hacken N. H. T. , van Oosterhout A. J. M. , Heijink I. H.
Published: October 2019

COPD is characterized by chronic lung inflammation and irreversible lung tissue damage. Inhaled noxious gases, including cigarette smoke, are the major risk factor for COPD. Inhaled smoke first encounters the epithelial lining of the lungs, causing oxidative stress and mitochondrial dysfunction. We investigated whether a mitochondrial defect may contribute to increased lung epithelial pro-inflammatory responses, impaired epithelial repair and reduced corticosteroid sensitivity as observed in COPD. We used wild-type alveolar epithelial cells A549 and mitochondrial DNA-depleted A549 cells (A549 Rho-0) and studied pro-inflammatory responses using (multiplex) ELISA as well as epithelial barrier function and repair (real-time impedance measurements), in the presence and absence of the inhaled corticosteroid budesonide. We observed that A549 Rho-0 cells secrete higher levels of pro-inflammatory cytokines than wild-type A549 cells and display impaired repair upon wounding. Budesonide strongly suppressed the production of neutrophil attractant CXCL8, and promoted epithelial integrity in A549 wild-type cells, while A549 Rho-0 cells displayed reduced corticosteroid sensitivity compared to wild-type cells. The reduced corticosteroid responsiveness may be mediated by glycolytic reprogramming, specifically glycolysis-associated PI3K signaling, as PI3K inhibitor LY294002 restored the sensitivity of CXCL8 secretion to corticosteroids in A549 Rho-0 cells. In conclusion, mitochondrial defects may lead to increased lung epithelial pro-inflammatory responses, reduced epithelial repair and reduced corticosteroid responsiveness in lung epithelium, thus potentially contributing to the pathogenesis of COPD.
Excellent supercapacitor and sensor performance of robust cobalt phosphinate ferrocenyl organic framework materials achieved by intrinsic redox and structure properties
Authors: Khrizanforov Mikhail , Shekurov Ruslan , Miluykov Vasily , Gilmanova Leysan , Kataeva Olga , Yamaleeva Zilya , Gerasimova Tatiana , Ermolaev Vadim , Gubaidullin Aidar , Laskin Artem , Budnikova Yulia
Published: October 2019

A new Co coordination polymer with phosphinates and Fc fragments was synthesized, which can be used as a water sensor and sorbent and also as a supercapacitor electrode.
Reactions of In–Zn bonds with organic azides: products that result from hetero- and homo-bimetallic behaviour
Authors: Anker Mathew D. , Altaf Yasir , Lein Matthias , Coles Martyn P.
Published: October 2019

Bimetallic compounds with indium–zinc bonds react with organic azides to give products consistent with hetero- and homo-bimetallic behaviour.
Antimetastatic effects of gossypol on colon cancer cells by targeting the u-PA and FAK pathways
Authors: Huang She-Fang , Chu Shu-Chen , Hsu Li-Sung , Tu Yu-Chen , Chen Pei-Ni , Hsieh Yih-Shou
Published: October 2019

Metastasis is the most prevalent cause of treatment failure in patients with colon cancer.
Effects of chemical interesterification on the triacylglycerols, solid fat contents and crystallization kinetics of palm oil-based fats
Authors: Zhang Zhen , Lee Wan Jun , Zhou Haiyan , Wang Yong
Published: October 2019

The effects of chemical interesterification (CIE) on the physicochemical properties and crystallization kinetics of oil blends containing palm oil (PO) in combination with six other types of oils were studied.
Correction: Advances in energy systems for valorization of aqueous byproducts generated from hydrothermal processing of biomass and systems thinking
Authors: Gu Yexuan , Zhang Xuesong , Deal Brian , Han Lujia , Zheng Jilu , Ben Haoxi
Published: October 2019

Correction for ‘Advances in energy systems for valorization of aqueous byproducts generated from hydrothermal processing of biomass and systems thinking’ by Yexuan Gu et al., Green Chem., 2019, 21, 2518–2543.
Correction: Integration of a phosphine ligand into an ionic liquid: a highly effective biphasic system for the Rh-catalyzed hydroformylation of 1-octene
Authors: Jin Xin , Feng Jianying , Ma Qingqing , Song Hongbing , Liu Qiangqiang , Xu Bingying , Zhang Mei , Li Shumei , Yu Shitao
Published: October 2019

Correction for ‘Integration of a phosphine ligand into an ionic liquid: a highly effective biphasic system for the Rh-catalyzed hydroformylation of 1-octene’ by Xin Jin et al., Green Chem., 2019, 21, 3267–3275.
Correction: Integration of phosphine ligands and ionic liquids both in structure and properties – a new strategy for separation, recovery, and recycling of homogeneous catalyst
Authors: Jin Xin , Feng Jianying , Song Hongbing , Yao Jiajun , Ma Qingqing , Zhang Mei , Yu Cong , Li Shumei , Yu Shitao
Published: October 2019

Correction for ‘Integration of phosphine ligands and ionic liquids both in structure and properties – a new strategy for separation, recovery, and recycling of homogeneous catalyst’ by Xin Jin et al., Green Chem., 2019, 21, 3583–3596.
A neutrophil membrane-functionalized black phosphorus riding inflammatory signal for positive feedback and multimode cancer therapy
Authors: Su Yujie , Wang Tingting , Su Yangnan , Li Min , Zhou Jianping , Zhang Wei , Wang Wei
Published: October 2019

Neutrophil membrane-functionalized black phosphorus achieved a positive feedback loop in a continuous “administrated-therapy” circle to progressively improve the tumor therapeutic efficiency.
Advanced functional surfaces through controlled damage and instabilities
Authors: Namdari Navid , Mohammadian Behrouz , Jafari Parham , Mohammadi Reza , Sojoudi Hossein , Ghasemi Hadi , Rizvi Reza
Published: October 2019

Functional surfaces are of paramount engineering importance for various applications. The purpose of this review is to present counter-intuitive methods of fabrication based upon damage or instabilities for creating value-added surface functions.
Anticancer auranofin engages 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) as a target
Authors: Tian Songhai , Siu Fung-Ming , Lok Chun-Nam , Fung Yi Man Eva , Che Chi-Ming
Published: October 2019

Subcellular fractionation method was used with HPLC-MS/MS technique for proteomics analysis to study the anticancer mechanism of action of auranofin. HMGCR is identified as a novel target of auranofin.
3D defective graphenes with subnanometric porosity obtained by soft-templating following zeolite procedures
Authors: Peng Lu , Doménech-Carbó Antonio , Primo Ana , García Hermenegildo
Published: October 2019

By applying the templating mechanism employed for the synthesis of mesoporous silicas to the structuration of sodium alginate, a novel defective 3D tubular graphene material (graphenolite) with hierarchical porous structure, very high powder specific surface area (1820 m2 g−1) has been obtained.
Manipulating the fluorescence of exciton–plasmon hybrids in the strong coupling regime with dual resonance enhancements
Authors: Qiu Yun-Hang , Ding Si-Jing , Nan Fan , Wang Qiang , Chen Kai , Hao Zhong-Hua , Zhou Li , Li Xiaoguang , Wang Qu-Quan
Published: October 2019

Tunable plexcitonic Rabi splitting and largely enhanced fluorescence in the strong coupling regime have been demonstrated in Cy5@Ag hybrids with dual resonance enhancements.
Mapping the dielectric constant of a single bacterial cell at the nanoscale with scanning dielectric force volume microscopy
Authors: Checa Martí , Millan-Solsona Ruben , Blanco Nuria , Torrents Eduard , Fabregas Rene , Gomila Gabriel
Published: October 2019

A method to map the dielectric constant of non-planar samples is presented, and applied to single bacterial cells.
PEG-modified aziridines for stereoselective synthesis of water-soluble fulleropyrrolidines
Authors: Kazakova Angelina V. , Konev Alexander S. , Zorin Ivan M. , Poshekhonov Igor S. , Korzhikov-Vlakh Viktor A. , Khlebnikov Alexander F.
Published: October 2019

A stereoselective synthesis of water-soluble pyrrolofullerenes as potential anti-HIV agents is reported.
Transition-metal- and oxidant-free three-component reaction of quinoline N-oxides, sodium metabisulfite and aryldiazonium tetrafluoroborates via a dual radical coupling process
Authors: You Guirong , Xi Dan , Sun Jian , Hao Liqiang , Xia Chengcai
Published: October 2019

Synthesis of 2-sulfonylquinolines via a three-component reaction of quinoline N-oxides, sodium metabisulfite, and aryldiazonium tetrafluoroborates under transition-metal- and oxidant-free conditions.
Temperature-controlled formation of inverse mesophases assembled from a rod–coil block copolymer
Authors: Lyu Xiaolin , Tang Zhehao , Xiao Anqi , Zhang Wei , Pan Hongbing , Shen Zhihao , Fan Xing-He
Published: October 2019

Temperature was adjusted to control the formation of inverse mesophases which can be used as templates to prepare inorganic materials.
Diastereoselective formal [3 + 3] cycloaddition of isatin-based α-(trifluoromethyl)imines with N,N′-dialkyloxyureas
Authors: Zhao Hong-Wu , Guo Jia-Ming , Wang Li-Ru , Ding Wan-Qiu , Tang Zhe , Song Xiu-Qing , Wu Hui-Hui , Fan Xiao-Zu , Bi Xiao-Fan
Published: October 2019

The diastereoselective formal [3 + 3] cycloaddition of isatin-based α-(trifluoromethyl)imines with N,N′-dialkyloxyureas furnished trans-configured novel spiro-1,3,5-triazinan-2-ones in reasonable chemical yields.
BCL11A: a potential diagnostic biomarker and therapeutic target in human diseases
Authors: Yin Jiawei , Xie Xiaoli , Ye Yufu , Wang Lijuan , Che Fengyuan
Published: October 2019

Transcription factor B-cell lymphoma/leukemia 11A (BCL11A) gene encodes a zinc-finger protein that is predominantly expressed in brain and hematopoietic tissue. BCL11A functions mainly as a transcriptional repressor that is crucial in brain, hematopoietic system development, as well as fetal-to-adult hemoglobin switching. The expression of this gene is regulated by microRNAs, transcription factors and genetic variations. A number of studies have recently shown that BCL11A is involved in β-hemoglobinopathies, hematological malignancies, malignant solid tumors, 2p15-p16.1 microdeletion syndrome, and Type II diabetes. It has been suggested that BCL11A may be a potential prognostic biomarker and therapeutic target for some diseases. In this review, we summarize the current research state of BCL11A, including its biochemistry, expression, regulation, function, and its possible clinical application in human diseases.
The inhibition of tumor protein p53 by microRNA-151a-3p induced cell proliferation, migration and invasion in nasopharyngeal carcinoma
Authors: Liu Haibin , Cheng Yin , Xu Yaping , Xu He , Lin Zheng , Fan Jingping , Lang Juntian
Published: October 2019

A close relation between microRNA-151a-3p (miR-151a-3p) and nasopharyngeal carcinoma (NPC) has been reported, however, the molecular mechanism is still unclear. The aim of the present study was to explore the mechanism in the promotion of miR-151a-3p to NPC progression. The levels of miR-151-3p in several NPC cell lines were detected in order to screen an experimental cell line. MiR-151a-3p mimic and inhibitor were constructed and transfected into 5-8F cells and cell proliferation were detected by Cell Counting Kit-8 (CCK-8). The apoptosis rate, cell migration and invasion were determined by flow cytometry, wound healing and Transwell assays. The predicted target was further verified by luciferase reporter assay. Real-time quantification-PCR and Western blot were carried out for mRNA and protein level analysis. Tumor protein p53 was co-transfected to verify the functions of miR-151a-3p. The miR-151a-3p level in NPC tissues was much higher than that in adjacent tissues. After transfecting cells with miR-151a-3p mimic, the cell proliferation and patients’ survival rate were much increased, and this was accompanied by the increase in B-cell lymphoma 2 (Bcl-2) and decreases in Bax and cleaved caspase-3 (P<0.01). Moreover, the migration rate and number of invaded cells were also remarkably increased, however, the miR-151a-3p inhibitor had opposite effects on the 5-8F cells. Noticeably, p53 was revealed as a potential target of miR-151a-3p. Co-transfection of P53 could partially reverse the promotive effects of miR-151a-3p on NPC cell progression. Our data indicated that blocking p53 expression and mediated signal pathways contribute to the positive effects of miR-151a-3p on NPC cell proliferation, migration and invasion.
Characterization of the interaction between β-catenin and sorting nexin 27: contribution of the type I PDZ-binding motif to Wnt signaling
Authors: DuChez Brian J. , Hueschen Christina L. , Zimmerman Seth P. , Baumer Yvonne , Wincovitch Stephen , Playford Martin P.
Published: October 2019

Background: Sorting Nexin 27 (SNX27) is a 62-kDa protein localized to early endosomes and known to regulate the intracellular trafficking of ion channels and receptors. In addition to a PX domain common among all of the sorting nexin family, SNX27 is the only sorting family member that contains a PDZ domain. To identify novel SNX27–PDZ binding partners, we performed a proteomic screen in mouse principal kidney cortical collecting duct cells (mpkCCD) using a GST-SNX27 fusion construct as bait. We found that the C-terminal type I PDZ binding motif (DTDL) of β-catenin, an adherens junction scaffolding protein and transcriptional co-activator, interacts directly with SNX27. Using biochemical and immunofluorescent techniques, β-catenin was identified in endosomal compartments where co-localization with SNX27 was observed. Furthermore, E-cadherin, but not Axin, GSK3 or Lef-1 was located in SNX27 protein complexes. While overexpression of wild-type β-catenin protein increased TCF-LEF dependent transcriptional activity, an enhanced transcriptional activity was not observed in cells expressing β-Catenin ΔFDTDL or diminished SNX27 expression.

These results imply importance of the C-terminal PDZ binding motif for the transcriptional activity of β-catenin and propose that SNX27 might be involved in the assembly of β-catenin complexes in the endosome.
Cible p-Soc pour l’apprentissage de Linux en DUT GEII
Authors: Aygalinc P. , Calvez S.
Published: October 2019

Les systèmes embarqués modernes utilisent souvent comme système d’exploitation Linux. Pour le DUT GEii, les architectures p-Soc (programmable-Systemonchip) trouvent grandement leur intérêt car elles permettent, en plus de l’apprentissage de ce système sur ses deux niveaux (user/kernel), d’entretenir et d’enrichir les connaissances acquises sur la description matérielle et l’informatique industrielle bas niveau. L’expérience menée ici décrit la plateforme développée dans ce cadre afin d’aborder d’une part les objectifs d’un système d’exploitation et de ses propriétés pour le développement d’applications de contrôle/commande en mode user, et d’autre part la conception de pilotes de périphériques du mode kernel sur des composants custom décrit en VHDL. Cet article traite aussi des prérequis nécessaires ainsi que des moyens indispensables à mettre en oeuvre par l’enseignant pour la mise en place de cet enseignement (prototypage rapide aussi bien au niveau matériel que logiciel).
Perspectives d’application du flux numérique au collage indirect
Authors: Pichon Pénélope , Cavaré Anaïs
Published: October 2019

Deux techniques de collage des attaches orthodontiques coexistent, le positionnement direct en bouche et le positionnement indirect sur un modèle puis le transfert sur le patient par l’utilisation de clés ou de gouttières. Si le collage indirect est aujourd’hui le plus employé en orthodontie linguale, la technique directe reste majoritaire en vestibulaire. Une nouvelle technique utilisant la CFAO permet de digitaliser les étapes du collage indirect, notamment le positionnement des attaches sur les moulages numériques et donc de faciliter le collage en gagnant en précision, en rapidité et en efficience.
Modification de l’encombrement mandibulaire antérieur grâce à une forme d’arcade mathématiquement optimisée
Authors: Chataigner Pierre-Alexandre , Sorel Olivier , Brezulier Damien
Published: October 2019

Des temps anciens jusqu’à nos jours, les formes d’arcades dentaires sont source de discordes en orthodontie. S’appuyant sur le bond technologique de ces dernières années et sur une chaine numérique toujours plus présente dans la pratique quotidienne, le logiciel présenté dans cet article tente d’apporter une réponse mathématique fiable à ce débat. En se basant sur la littérature, l’algorithme propose une individualisation des formes d’arcades dentaires permettant de se rapprocher d’un idéal thérapeutique propre à chaque patient. Afin de tester les arcades obtenues, une étude rétrospective a été menée sur 37 patients du CHU de Rennes. Elle a permis de comparer les valeurs d’encombrement avant et après modification de la forme d’arcade par l’algorithme. Les résultats montrent des différences fortement significatives entre l’encombrement initial et l’encombrement théorique suivant les formes d’arcades calculées. Les progrès technologiques permettent donc d’entrevoir une optimisation des traitements passant par l’individualisation de chaque cas.
Seltene Ursache einer gastrointestinalen Blutung
Authors: Rollandi Ludovica-Paola , Kasper Judith , Schaller Tina
Published: October 2019

Anamnese und klinischer Befund Wir berichten über einen 66-jährigen Patienten mit Plasmozytom, der sich mit seit 3 Tagen bestehendem Teerstuhl, Schwindel und Belastungsdyspnoe vorstellte.

Untersuchung und Diagnose Klinisch und laborchemisch wurde die Verdachtsdiagnose einer kreislaufwirksamen, aktiven gastrointestinalen Blutung gestellt. In der Gastroduodenoskopie und Sigmoidoskopie war keine aktive Blutungsquelle aufzufinden, sodass eine Computertomografie durchgeführt wurde, in der eine auffallende Ballonierung des proximalen Jejunums sowie eine abnormale, pathologische Kontrastmittelanreicherung zu sehen waren. In der anschließend zielgerichteten Jejunoskopie fiel ein aktiv blutender Tumor auf.

Therapie und Verlauf Aufgrund des bekannten Plasmozytomleidens des Patienten wurde die Verdachtsdiagnose einer aktiv blutenden extramedullären Plasmozytommetastase gestellt. Da in der Jejunoskopie nur eine temporäre Blutstillung möglich war, erfolgte eine Segmentresektion des Dünndarms. Die histologische Untersuchung bestätigte die Verdachtsdiagnose.

Folgerung Die Differenzialdiagnose der gastrointestinalen Blutung umfasst auch tumoröse Veränderungen des Dünndarms. Die CT-Diagnostik kann wichtige Hinweise auf Lokalisation und Ursache einer gastrointestinalen Blutung liefern.
Corrective Osteosynthesis in Failed Proximal Humeral Fractures
Authors: Dey Hazra Rony-Orijit , Lill Helmut , Ellwein Alexander , Warnhoff Mara , Jensen Gunnar
Published: October 2019

Despite implant improvement and increasing standardisation of operation techniques, the rate of therapy failure of proximal humeral fracture care with primary osteosyntheses is estimated to be 10 to 20%. Most commonly failure is precipitated by: material failure, technical error, non-anatomical repositioning, avascular necrosis, lacking medial support. An additive medial stabilisation of the so-called “calcar region” can decrease failure rates significantly. An early correction osteosynthesis with the purpose of restoring the anatomy is indicated in bony, non-consolidated “fresh” fractures. Bony consolidated fractures should be classified according to Boileau and Walch. The authors of this article advice a structured and classification-adapted approach to treatment with a correction osteosynthesis. Post-traumatic deficits can be augmented utilising the following methods: correction osteosynthesis with allogeneic/autologous bone grafts, correction osteosynthesis with
hydroxyapatite grafts. For the additive stabilisation of repositioned and fixated fractures, the following are described: correction osteosynthesis with an additive ventral one-third tubular plate, correction osteosynthesis with cement-augmented screws. Based on results of endoprosthetics following fractures of the proximal humerus, the correction osteosynthesis indeed represents a real therapeutic alternative in patients that are below the age of 60, a good bone mass and with relative functional requirements.
The Effect of Temperature on the Stability of In-Use Insulin Pens
Authors: Kongmalai Tanawan , Preechasuk Lukana , Junnu Sarawut , Manocheewa Siriphan , Srisawat Chatchawan , Sriwijitkamol Apiradee
Published: October 2019

Background Improper storage of insulin could decrease its potency. Manufacturers recommend that in-use insulin pens should be kept at between 25–30°C, but room temperature in tropical countries often exceeds this range. This study investigates the effect of temperature on the stability of basal insulin in cartridges 28 days after opening.

Methods Four different basal insulins were evaluated. Five opened pens of each insulin type were included for each of three storage conditions and 5 unopened insulin pens of each type were stored in the refrigerator as a control. The opened pens were stored for 28 days in either a refrigerator (2–8 °C), at room temperature, or in an incubator (37 °C). Each day insulin pens were mixed 20 times and 2 units were discarded to mimic daily usage. Insulin quantity was evaluated using an ultra-high-performance liquid chromatography assay.

Results The average room temperature during the study period was 29.7 °C. After 28 days, the percentage amount of insulin stored at refrigerator, room temperature or incubator, compared with control was 99.0, 99.7, 101.1% for long-acting insulin; 97.4, 97.2, 99.0% for NPH-1; 101.4, 101.5, 100.7% for NPH-2; and 98.7, 97.8, 98.5% for NPH-3. There were no statistically significant differences. However, we observed a trend toward different stability between clear insulin analog and turbid NPH insulin.

Conclusions Temperature as high as 37°C and cyclic temperature,had no effect on the stability of in-use insulin pen.
Personbezogene Faktoren im bio-psycho-sozialen Modell der WHO: Systematik der Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP)
Authors: Grotkamp Sabine , Cibis Wolfgang , Brüggemann Silke , Coenen M. Michaela , Gmünder Hans-Peter , Keller Klaus , Nüchtern Elisabeth , Schwegler Urban , Seger Wolfgang , Staubli Stefan , Raison B. Bia von , Weißmann R , Bahemann A. , Fuchs H. , Rink M. , Schian Marcus , Schmitt Klaus
Published: October 2019

Hintergrund Die Arbeitsgruppe „ICF“ des Fachbereichs II „Praktische Sozialmedizin und Rehabilitation“ der Deutschen Gesellschaft für Sozialmedizin und Prävention (DGSMP) entwarf 2010 eine Liste personbezogener Faktoren (PF) für den deutschen Sprachraum. Zwischenzeitlich haben die ICF und das bio-psycho-soziale Modell der WHO eine verstärkte Verankerung im SGB IX gefunden. So hat der Gesetzgeber verbindlich bestimmt, dass im Reha-Prozess eine Bedarfsfeststellung „umfassend“ zu erfolgen hat. Damit sind die PF ein obligatorischer Bestandteil der Bedarfsermittlung.

Ziel Ziel der vorliegenden Arbeit ist es, eine aktualisierte Fassung der PF für die (sozialmedizinische) Begutachtung im deutschen Sprachraum vorzulegen. Dazu erfolgte eine Auseinandersetzung mit bereits publizierten Vorschlägen anderer Autoren, insbesondere mit der Arbeit von Geyh et al.

Methodik Die multiprofessionell zusammengesetzte Arbeitsgruppe überprüfte mittels einer qualitativen Herangehensweise die Grundstruktur, Konsistenz und Faktorenauswahl der DGSMP-Systematik und modifizierte diese, sofern sinnvoll und erforderlich. Die Grundsätze für die Faktorenauswahl wurden analog zur Publikation von 2010 beibehalten.

Ergebnisse Eine grundlegende Anpassung war nicht erforderlich, die Grundstruktur der Systematik blieb im Wesentlichen erhalten. Einige Kategorien wurden ergänzt, gestrichen, zusammengefasst, verschoben sowie redaktionell oder inhaltlich überarbeitet. Eine Systematik zu PF ist als solche datenschutzrechtlich grundsätzlich unbedenklich. Die Zulässigkeit einer Erhebung von einzelnen PF im Rahmen der Bedarfsermittlung und -feststellung wird nach ihrer Erforderlichkeit im konkreten Einzelfall für die Erfüllung der gesetzlichen Aufgaben beurteilt.

Ausblick Die überarbeitete DGSMP-Systematik ermöglicht es dem Anwender, relevante Einflüsse aus dem Lebenshintergrund einer Person strukturiert zu beschreiben und zu dokumentieren. Damit können Einflüsse auf die Teilhabe eines Menschen auf Grundlage des bio-psycho-sozialen Modells umfassend und transparent dargestellt werden. Der Weg zu einer justiziablen Leistungsallokation und umfassenden Nutzung, insbesondere im gesamten Reha-Prozess wird erleichtert.
Pulmonale Hypertonie: Update 2019
Authors: Rosenkranz Stephan
Published: October 2019

Pulmonale Hypertonie (PH) ist ein hämodynamischer Zustand, der als gemeinsame Konsequenz einer Reihe von Erkrankungen entstehen kann, die aufgrund unterschiedlicher Pathomechanismen zu einer Erhöhung des pulmonal arteriellen Drucks und infolge dessen zu chronischer Rechtsherzbelastung führen. Je nach zugrunde liegender Ursache untergliedert die klinische Klassifikation die PH in 5 Gruppen: Pulmonal arterielle Hypertonie (Gruppe 1), PH in Zusammenhang mit Linksherzerkrankungen (Gruppe 2), PH bei chronischen Lungenerkrankungen (Gruppe 3), chronisch-thromboembolische PH (CTEPH; Gruppe 4) und PH aufgrund unklarer und/oder multifaktorieller Mechanismen (Gruppe 5). Dieser Artikel fokussiert auf die klinische Relevanz dieser Untergliederung und das unterschiedliche Management der verschiedenen PH-Formen. Er beleuchtet zudem kritisch neue Entwicklungen wie die modifizierte hämodynamische Definition der PH.
Convenient Synthesis of Fluorescent Chromeno[4,3-d]pyrimidines from Electron-Deficient 3-Vinylchromones
Authors: Chernov Nikita M. , Shutov Roman V. , Potapova Anastasia E. , Yakovlev Igor P.
Published: October 2019

We report an easy and powerful approach to the synthesis of novel chromeno[4,3-d]pyrimidine-5-acetic acids through ANRORC reaction of electron-deficient 3-vinylchromones and 1,3-N,N-binucleophiles. The reaction proceeds under mild conditions (EtOH, rt) and is applicable to a wide range of substrates. The described compounds show fluorescence in the violet-blue range (390–460 nm) with Stokes shift of 40–80 nm and moderate quantum yield (0.15–0.20). As the electron-withdrawing group is conserved in the form of an acetic acid fragment, these compounds may readily be functionalized or conjugated to a required substrate for (bio)analytical purposes.
Upgrading Therapy Strategy Improves Pregnancy Outcome in Antiphospholipid Syndrome: A Cohort Management Study
Authors: Hoxha Ariela , Favaro Maria , Calligaro Antonia , Del Ross Teresa , Ruffatti Alessandra Teresa , Infantolino Chiara , Tonello Marta , Mattia Elena , Ruffatti Amelia
Published: October 2019

The current study evaluates the efficacy and safety of different treatment strategies for pregnant patients with antiphospholipid syndrome. One hundred twenty-seven consecutive pregnancies were assessed; 87 (68.5%) with a history of pregnancy morbidity alone were treated with prophylactic low molecular weight heparin (LMWH) + low-dose aspirin (LDA, 100 mg) (group I) and 40 (31.5%) with a history of thrombosis and/or severe pregnancy complications with therapeutic LMWH + LDA (group II). LMWH doses were increased throughout the pregnancies depending on the patients' weight gain, and treatment was switched to a more intensive one at the first sign of maternal/fetal complications. The study's primary outcome was live births. There were no significant differences in live birth rate between group I (95.4%) and group II (87.5%). Even fetal complication rate was similar in the two groups; group II nevertheless had a higher prevalence of maternal and neonatal complications (p = 0.0005 and p = 0.01, respectively) and registered a significantly lower gestational age at delivery and birth weight (p = 0.0001 and p = 0.0005, respectively). Two patients in group I switched to group II therapy, six patients in group II switched to a more intensive treatment strategy (weekly plasma exchange + fortnightly intravenous immunoglobulins in addition to therapeutic LMWH + LDA). The multivariate analysis uncovered that triple antiphospholipid antibodies positivity was an independent factor leading to a more intensive therapy. All eight switched patients achieved a live birth. Study results revealed that adjusted LMWH doses and switching therapy at first signs of severe pregnancy complications led to a high rate of live births in antiphospholipid syndrome patients.
Familial Sleep Disorders in Unknown Genetic Syndrome
Authors: Lelii Mara , Baggi Elena , Senatore Laura , Bedeschi Maria Francesca , Dilena Robertino , Iascone Maria , Gangi Silvana , Marchisio Paola , Patria Maria Francesca
Published: October 2019

Sleep-disordered breathing (SDB) is common in children, especially in those with congenital or genetic diseases. The factors involved include obstructive sleep apnea, disrupted rapid eye movement sleep, and central hypoventilation. Diagnosing and treating SDB in these children have a positive impact on the quality of life of them and their families, reducing the risk of both further impairment of cognitive abilities and cardiopulmonary complications. We report a familial case of SDB with central hypoventilation, in which identification of the disorder in the younger sister led to the unfortunately late diagnosis and treatment of the same condition in the older sister.
Measurement and control of emergent phenomena emulated by resistive-capacitive networks, using fractional-order internal model control and external adaptive control
Authors: Galvão Roberto K. H. , Hadjiloucas Sillas
Published: October 2019

A fractional-order internal model control technique is applied to a three-dimensional resistive-capacitive network to enforce desired closed-loop dynamics of first order. In order to handle model mismatch issues resulting from the random allocation of the components within the network, the control law is augmented with a model-reference adaptive strategy in an external loop. By imposing a control law on the system to obey first order dynamics, a calibrated transient response is ensured. The methodology enables feedback control of complex systems with emergent responses and is robust in the presence of measurement noise or under conditions of poor model identification. Furthermore, it is also applicable to systems that exhibit higher order fractional dynamics. Examples of feedback-controlled transduction include cantilever positioning in atomic force microscopy or the control of complex de-excitation lifetimes encountered in many types of spectroscopies, e.g., nuclear magnetic, electron-spin, microwave, multiphoton fluorescence, Förster resonance, etc. The proposed solution should also find important applications in more complex electronic, microwave, and photonic lock-in problems. Finally, there are further applications across the broader measurement science and instrumentation community when designing complex feedback systems at the system level, e.g., ensuring the adaptive control of distributed physiological processes through the use of biomedical implants.
A systematic error modeling and separation method for the special cylindrical profile measurement based on 2-dimension laser displacement sensor
Authors: Zhang Maowei , Liu Yongmeng , Sun Chuanzhi , Wang Xiaoming , Tan Jiubin
Published: October 2019

The aim of this study is to improve aeroengine multistage rotor performance and to reduce the incidence of failures. Measuring the form error of seam allowance connecting cylindrical surface accurately is critical to achieve rotor optimal stack assembly stage-by-stage. In this paper, compared to the traditional cylindrical profile measurement model, a more comprehensive measurement model was built based on a 2-dimensional line laser sensor measurement technique, a model in which the component eccentricity error e, the sensor lateral offset error d, the sensor forward tilt error θx, the sensor lateral tilt error θy, and the rotary table tilt error γ were gradually modeled and separated. The particle swarm optimization algorithm was adopted to solve the model error parameters. The residual error simulation was performed to observe the effect of different levels of offset errors on the measurement results. The aeroengine rotor seam allowance surface measurement experiment was performed to verify the validity of the method model. We can conclude that the sensor lateral offset error d was 3.214 µm, sensor forward tilt error θx was 12.754″, sensor lateral tilt error θy was 10.365″, and rotary table tilt error γ was 2.146″. The cylindricity error value was 3.701 µm. Compared with the traditional cylindrical profile measurement method, the measurement accuracy of cylindricity error was improved by 1.768 µm. The proposed method can improve the measurement accuracy significantly of multistage rotors in the aeroengine measurement process; besides, it can also be extended to the measurement of other geometric form errors.
Transition from high-entropy to Cu-based (TiZrNbNi)1−xCux metallic glasses
Authors: Ristić Ramir , Figueroa Ignacio A. , Lachová Andrea , Michalik Štefan , Mikšić Trontl Vesna , Pervan Petar , Zadro Krešo , Pajić Damir , Babić Emil
Published: October 2019

A study of a transition from conventional multicomponent alloys to high-entropy alloys (HEAs) is important both for understanding the formation of HEAs and for proper evaluation of their potential with respect to that of conventional alloys. We report the main result of such a study performed on (TiZrNbNi)1−xCux metallic glasses (MG) over a broad concentration range x ≤ 0.52 encompassing both high-entropy-MGs and Cu-based MGs. A comprehensive study of the composition, homogeneity, thermal stability, atomic structure, electronic structure, and magnetic susceptibility of 11 alloys has been performed. Thermal analysis revealed a rather weak variation of thermal parameters and glass forming ability with x. The study of the atomic structure showed a linear variation of average interatomic distances and atomic volumes close to those predicted by Vegard's law. The coordination numbers and atomic packing fractions were constant throughout the explored concentration range. The electronic density of states (DOS) showed a split-band structure with DOS close to the Fermi level dominated with d-states of Ti, Zr, and Nb. Accordingly, magnetic susceptibility decreased linearly with x and extrapolated to that of Cu. Thus, the studied alloys show ideal solution behavior similar to that of binary Cu-Ti, Zr, and Hf MGs. The results are compared with those for (TiZrNbCu)1−xNix MGs and (CrMnFeCo)1−xNix alloys and their impact on understanding the transition from high-entropy-MGs to conventional MGs with the same composition is briefly discussed.
Numerical study of hydrodynamic loads at early stage of vertical high-speed water entry of an axisymmetric blunt body
Authors: Hong Yao , Wang Benlong , Liu Hua
Published: October 2019

The vertical water-entry of a cylinder with a flat bottom at a high-speed impact velocity is investigated numerically in this paper. The multiphase solver is based on the reduced five-equation model and adopts a pressure relaxation method. The fluid is assumed as inviscid and compressible. The effect of gravity is neglected because of the high Froude number and short loading period. A series of numerical experiments are conducted, and the influence of the impact velocity and aeration effect on the slamming loads are studied. The results show that the compressibility of the fluid is important as the impact velocity increases and the acoustic pressure underestimates the maximum impact pressure. Moreover, as the aeration level grows, both the impact loads and the affected area will decrease. Simplified theoretical equations based on the shock jump relation are proposed to predict the maximum impact loads, showing a good agreement with the numerical results. The dimensional analysis results show that the impact loads in pure and aerated water follow the same relation vs Mach number, which can be used to measure the high-speed impact force at a lower impact velocity in aerated water.
Molecular beam epitaxial growth of scandium nitride on hexagonal SiC, GaN, and AlN
Authors: Casamento Joseph , Wright John , Chaudhuri Reet , Xing Huili (Grace) , Jena Debdeep
Published: October 2019

RF plasma assisted MBE growth of scandium nitride (ScN) thin films on Ga-polar GaN (0001)/SiC, Al-polar AlN (0001)/Al2O3, and Si-face 6H-SiC (0001) hexagonal substrates is found to lead to a face centered cubic (rock salt) crystal structure with (111) out-of-plane orientation instead of hexagonal orientation. Cubic (111) twinned patterns in ScN are observed by in situ electron diffraction during epitaxy, and the twin domains in ScN are detected by electron backscattered diffraction and further corroborated by X-ray diffraction. The epitaxial ScN films display very smooth, subnanometer surface roughness at a growth temperature of 750 °C. Temperature-dependent Hall-effect measurements indicate a constant high n-type carrier concentration of ∼1 × 1020/cm3 and an electron mobility of ∼20 cm2/V s.
Polycrystalline Co2Mn-based Heusler thin films with high spin polarization and low magnetic damping
Authors: Guillemard C. , Petit-Watelot S. , Rojas-Sánchez J.-C. , Hohlfeld J. , Ghanbaja J. , Bataille A. , Le Fèvre P. , Bertran F. , Andrieu S.
Published: October 2019

Spin-polarization and magnetic damping are measured for several polycrystalline films with each of them being made of a different single Co2Mn-based Heusler compound. As several epitaxial Co2Mn-based Heusler compounds are shown to be half-metal magnetic materials with full spin-polarization and ultralow magnetic damping, we explore here these properties but in polycrystalline films. Co2MnSi, Co2MnGe, and Co2MnGa thin films were grown on glass substrates and analyzed in situ by electron diffraction and spin-resolved photoemission and ex situ by transmission electron microscopy and ferromagnetic resonance. Despite the polycrystalline state of the films, they still exhibit high spin polarizations and very low magnetic damping coefficients. The latter are at least of the same order as the best epitaxial films using regular ferromagnetic materials. The key point to achieve such properties is to control the Heusler stoichiometry as best as possible.
Influence of flowing fluid property through an elastic tube on various deformations along the tube length
Authors: Nahar Samsun , Dubey Bipro N. , Windhab Erich J.
Published: October 2019

The study of fluid flow characteristics in collapsible elastic tubes is useful to understand biofluid mechanics encountered in the human body. The research work presented here is aimed at thoroughly investigating the influence of both Newtonian and/or non-Newtonian fluids (low and high shear thinning) during steady flow through an elastic tube on various tube deformations, which enables understanding of the interaction between wall motion, fluid flow, and intestinal transmembrane mass transfer as a crucial contribution to a mechanistic understanding of bioaccessibility/bioavailability. It is observed that for a given steady volume flow rate, the tube is buckled from an elliptical shape to a line or area contacted two lobes as the critical external pressure is increased. The downstream transmural pressure is found to get more negative than that at the upstream as the outlet pressure decreased due to stronger tube collapse resulting in a reduced cross-sectional area. The experimental results depict that the tube cross-sectional area decreased by only about a factor of one for PEG (polyethylene glycol) and about a factor of six for both CMC (carboxymethyl cellulose) and PAA (polyacrylamide) from the undeformed one under an applied external pressure of 105 mbar. The corresponding maximum velocity increased by a factor of two during steady flow of shear-thinning fluids. The shear-thinning behavior of both CMC and PAA solutions is clearly observed at a constant flow rate of 17 ml/s as the tube cross-sectional area decreased due to an increase in compressive transmural pressure. In addition, the viscosity of PAA is drastically decreased due to its high shear-thinning behavior than that of the CMC under the same applied external pressure.