bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the Safety and Toxicity of the Original Copper Nanocomposite Based on Poly-N-vinylimidazole
Authors: Shurygina Irina A. , Prozorova Galina F. , Trukhan Irina S. , Korzhova Svetlana A. , Dremina Nataliya N. , Emel’yanov Artem I. , Say Olesya V. , Kuznetsova Nadezhda P. , Pozdnyakov Alexander S. , Shurygin Michael G.
Published: December 2021

A new original copper nanocomposite based on poly-N-vinylimidazole was synthesized and characterized by a complex of modern physicochemical and biological methods. The low cytotoxicity of the copper nanocomposite in relation to the cultured hepatocyte cells was found. The possibility to involve the copper from the nanocomposite in the functioning of the copper-dependent enzyme systems was evaluated during the incubation of the hepatocyte culture with this nanocomposite introduced to the nutrient medium. The synthesized new water-soluble copper-containing nanocomposite is promising for biotechnological and biomedical research as a new non-toxic hydrophilic preparation that is allowed to regulate the work of key enzymes involved in energy metabolism and antioxidant protection as well as potentially serving as an additional source of copper.
Surface Coating-Modulated Phytotoxic Responses of Silver Nanoparticles in Plants and Freshwater Green Algae
Authors: Biba Renata , Košpić Karla , Komazec Bruno , Markulin Dora , Cvjetko Petra , Pavoković Dubravko , Peharec Štefanić Petra , Tkalec Mirta , Balen Biljana
Published: December 2021

Silver nanoparticles (AgNPs) have been implemented in a wide range of commercial products, resulting in their unregulated release into aquatic as well as terrestrial systems. This raises concerns over their impending environmental effects. Once released into the environment, they are prone to various transformation processes that modify their reactivity. In order to increase AgNP stability, different stabilizing coatings are applied during their synthesis. However, coating agents determine particle size and shape and influence their solubility, reactivity, and overall stability as well as their behavior and transformations in the biological medium. In this review, we attempt to give an overview on how the employment of different stabilizing coatings can modulate AgNP-induced phytotoxicity with respect to growth, physiology, and gene and protein expression in terrestrial and aquatic plants and freshwater algae.
Bioactive Foods Decrease Liver and Brain Alterations Induced by a High-Fat-Sucrose Diet through Restoration of Gut Microbiota and Antioxidant Enzymes
Authors: Syeda Tauqeerunnisa , Sánchez-Tapia Mónica , Orta Itzel , Granados-Portillo Omar , Pérez-Jimenez Lizbeth , Rodríguez-Callejas Juan-de-Dios , Toribio Samuel , Silva-Lucero Maria-del-Carmen , Rivera Ana-Leonor , Tovar Armando , Torres Nimbe , Perez-Cruz Claudia
Published: December 2021

Obesity is associated with cognitive deficit and liver alterations; however, it remains unclear whether a combination of functional foods could reverse cognitive damage and to what extent it would be associated with changes in gut microbiota and liver. With this aim, male Wistar rats were fed a high-fat-5%sucrose diet (HFS) for 4 mo. And were then fed for 1 mo. with bioactive foods. At the end of this period, liver, serum, feces, intestine, and brain samples were taken. Body composition, energy expenditure, LPS, hormones, intraperitoneal glucose tolerance test, behavioral tests, and gut microbiota were evaluated. We showed that male rats fed high-fat-sucrose diet developed gut microbiota dysbiosis, increased in body fat, decreased antioxidant activity, decreased brain neuropeptide Y, increased the number of astrocytes and activated microglia, along with reduced spine density associated with deficits in working memory. Ingestion of a combination of nopal, soy protein, curcumin, and chia seed oil (bioactive foods) for three months was associated with an increase in a cluster of bacteria with anti-inflammatory capacity, a decrease in serum LPS levels and an increase in serum eicosapentaenoic acid (EPA) with neuroprotective properties. In the liver, ingestion of bioactive food significantly increased antioxidant enzymes, decreased lipogenesis, reduced inflammation mediated by the TLR4-TNFα pathway along with a decrease in body fat, glucose intolerance, and metabolic inflexibility. Finally, neuroinflammation in the brain was reduced and working memory improved. Our study demonstrates that consumption of bioactive foods was associated with reduced liver, brain, and gut microbiota alterations in obese rats.
The Role of Vitamin D Supplementation in Children with Autism Spectrum Disorder: A Narrative Review
Authors: Kittana Monia , Ahmadani Asma , Stojanovska Lily , Attlee Amita
Published: December 2021

Children with autism spectrum disorder (ASD) present with persistent deficits in both social communication and interactions, along with the presence of restricted and repetitive behaviors, resulting in significant impairment in significant areas of functioning. Children with ASD consistently reported significantly lower vitamin D levels than typically developing children. Moreover, vitamin D deficiency was found to be strongly correlated with ASD severity. Theoretically, vitamin D can affect neurodevelopment in children with ASD through its anti-inflammatory properties, stimulating the production of neurotrophins, decreasing the risk of seizures, and regulating glutathione and serotonin levels. A Title/Abstract specific search for publications on Vitamin D supplementation trials up to June 2021 was performed using two databases: PubMed and Cochrane Library. Twelve experimental studies were included in the synthesis of this review. Children with ASD reported a high prevalence of vitamin D deficiency or insufficiency. In general, it was observed that improved vitamin D status significantly reduced the ASD severity, however, this effect was not consistently different between the treatment and control groups. The variations in vitamin D dose protocols and the presence of concurrent interventions might provide an explanation for the variability of results. The age of the child for introducing vitamin D intervention was identified as a possible factor determining the effectiveness of the treatment. Common limitations included a small number of participants and a short duration of follow-ups in the selected studies. Long-term, well-designed randomized controlled trials are warranted to confirm the effect of vitamin D on severity in children with ASD.
HPLC/MSn Profiling and Healing Activity of a Muco-Adhesive Formula of Salvadora persica against Acetic Acid-Induced Oral Ulcer in Rats
Authors: Ayoub Nahla , Badr Nadia , Al-Ghamdi Saeed S. , Alsanosi Safaa , Alzahrani Abdullah R. , Abdel-Naim Ashraf B. , Nematallah Khaled A. , Swilam Noha
Published: December 2021

Salvadora persica L. (S. persica, Siwak) is an ethnic plant that is widely used for improving oral hygiene. This study aimed to provide a phytochemical profiling of S. persica ethyl acetate fraction (SPEAF) and to evaluate the healing activity of a muco-adhesive formula of the fraction against acetic acid-induced oral ulcers in rats. HPLC-ESI-QTOF-MS-MS analysis of SPEAF resulted in the tentative identification of 56 metabolites containing fatty acids (23%), urea derivatives (10.5%) and sulphur compounds (10%), in addition to several amides, polyphenols and organic acids (6.5%, 5% and 2%, respectively). For the first time, 19 compounds were identified from S. persica. In vitro and in vivo experiments indicated that the extract is non-toxic. SPEAF exhibited superior healing activities compared to both the negative and positive control groups on days 7 and 14 of tongue ulcer induction. This was confirmed by histopathological examinations of haematoxylin and eosin-stained (H&E) and Masson’s trichrome-stained tongue sections. Moreover, SPEAF showed potent anti-inflammatory activities, as evidenced by the inhibited expression of interleukin-6 (IL-6) and tumour necrosis alpha (TNF-α). Moreover, SPEAF exhibited potent antioxidant activity, as it prevented malondialdehyde (MDA) accumulation, reduced glutathione (GSH) depletion and superoxide dismutase (SOD) exhaustion. SPEAF significantly enhanced hydroxyproline tongue content and upregulated collagen type I alpha 1 (Col1A1) mRNA expression. SPEAF also improved angiogenesis, as shown by the increased mRNA expression of the angiopoietin-1 (Ang-1). In conclusion, S. persica has a wide range of secondary metabolites and ameliorates acetic acid-induced tongue ulcers in rats. This can be attributed, at least partly, to its anti-inflammatory, antioxidant, procollagen and angiogenic activities. These findings provide support and validity for the use of S. persica as a traditional and conventional treatment for oral disorders.
The Role of the Thoracic Spine during Breathing in Osteogenesis Imperfecta: A Combined Traditional Morphometry and 3D Geometric Morphometrics Research
Authors: González-Ruiz José María , Palancar Carlos A. , Mata Escolano Federico , Llido Susanna , Torres-Sanchez Isabel , García-Río Francisco , Bastir Markus , Sanchis-Gimeno Juan A.
Published: December 2021

OsteogenesisImperfecta (OI) is a rare disease with respiratory problems, which are usually attributed to the secondary effects of scoliosis and rib fractures and to severe restrictive pulmonary disease. Conventional morphometry has already been studied in OI patients but three-dimensional geometric morphometrics (3D GMM) has never been used to assess how the thoracic spine shape changes during maximal breathing. A total of 6 adult subjects with OI type III and 16 healthy controls underwent a spirometric study and two computed tomography scans in maximal inspiration and expiration. Shape data by means of 3D GMM and Cobb angle values of scoliosis and kyphosis were obtained and their relationship with spirometric values was analysed using regressions and mean shape comparisons. No differences in kyphosis (p = 0.285) and scoliosis Cobb values (p = 0.407) were found between inspiration and expiration in OI patients. The 3D GMM analysis revealed significant shape differences between OI and control subjects (p < 0.001) that were related to the inspiration (p = 0.030) and not to the expiration (p = 0.079). Nevertheless, no significant relation was found between thoracic spine shape, scoliosis, kyphosis and breathing outcomes in both OI patients and controls. There were thoracic spine shape differences during maximal breathing between OI patients and controls that were mainly related to the inspiration.
Temporal Study of Salmonella enterica Serovars Isolated from Fluff Samples from Ontario Poultry Hatcheries between 2009 and 2018
Authors: Murray Carolyn E. , Varga Csaba , Ouckama Rachel , Guerin Michele T.
Published: December 2021

The objectives of this study were to determine the prevalence, temporal trends, seasonal patterns, and temporal clustering of Salmonella enterica isolated from fluff samples from poultry hatcheries in Ontario between 2009 and 2018. A scan statistic was used to identify clusters of common serovars and those of human health concern. A multi-level logistic regression model was used to identify factors (poultry commodity, year, season) associated with S. enterica presence. The period prevalence of S. enterica was 7.5% in broiler hatcheries, 1.6% in layer hatcheries, 7.6% in turkey hatcheries, 29.7% in waterfowl hatcheries, and 13.8% in game-bird hatcheries. An overall increasing trend in S. enterica prevalence was identified in waterfowl and game-bird hatcheries, while a decreasing trend was identified in broiler and turkey hatcheries. Overall, the most common S. enterica serovars were Kentucky, Enteritidis, Heidelberg, and Senftenberg. Salmonella enterica ser. Enteritidis was the most common serovar in waterfowl hatcheries. Temporal clusters were identified for all poultry commodities. Seasonal effects varied by commodity, with the highest odds of S. enterica occurring in the summer and fall. Our study offers information on the prevalence and temporality of S. enterica serovars that might guide prevention and control programs at the hatchery level.
Differences in Distribution and Detection Rate of the [68Ga]Ga-PSMA Ligands PSMA-617, -I&T and -11—Inter-Individual Comparison in Patients with Biochemical Relapse of Prostate Cancer
Authors: Gühne Falk , Radke Stefanie , Winkens Thomas , Kühnel Christian , Greiser Julia , Seifert Philipp , Drescher Robert , Freesmeyer Martin
Published: December 2021

The biochemical relapse of prostate cancer is diagnostically challenging but of high clinical impact for subsequent patient treatment. PET/CT with radiolabeled PSMA ligands outperforms conventional diagnostic methods in the detection of tumor recurrence. Several radiopharmaceuticals were and are available for use. The aim of this study was to investigate whether the routinely applied [68Ga]Ga-PSMA ligands PSMA-617, -I&T and -11 (HBED-CC) differ in physiological and pathological distribution, or in tumor detection rate. A retrospective evaluation of 190 patients (39 patients received PSMA-617, 68 patients PSMA-I&T and 83 patients PSMA-11) showed significant differences in tracer accumulation within all organs examined. The low retention within the compartments blood pool, bone and muscle tissue is a theoretical advantage of PSMA-11. Evaluation of tumor lesion uptake and detection rate did not reveal superiority of one of the three radiopharmaceuticals, neither in the whole population, nor in particularly challenging subgroups like patients with very low PSA levels. We conclude that all three [68Ga]Ga-PSMA ligands are equally feasible in this clinically important scenario, and may replace each other in case of unavailability or production restrictions.
Recent Advances in Structure, Function, and Pharmacology of Class A Lipid GPCRs: Opportunities and Challenges for Drug Discovery
Authors: Krishna Deepak R. N. V. , Verma Ravi Kumar , Hartono Yossa Dwi , Yew Wen Shan , Fan Hao
Published: December 2021

Great progress has been made over the past decade in understanding the structural, functional, and pharmacological diversity of lipid GPCRs. From the first determination of the crystal structure of bovine rhodopsin in 2000, much progress has been made in the field of GPCR structural biology. The extraordinary progress in structural biology and pharmacology of GPCRs, coupled with rapid advances in computational approaches to study receptor dynamics and receptor-ligand interactions, has broadened our comprehension of the structural and functional facets of the receptor family members and has helped usher in a modern age of structure-based drug design and development. First, we provide a primer on lipid mediators and lipid GPCRs and their role in physiology and diseases as well as their value as drug targets. Second, we summarize the current advancements in the understanding of structural features of lipid GPCRs, such as the structural variation of their extracellular domains, diversity of their orthosteric and allosteric ligand binding sites, and molecular mechanisms of ligand binding. Third, we close by collating the emerging paradigms and opportunities in targeting lipid GPCRs, including a brief discussion on current strategies, challenges, and the future outlook.
Nitric Oxide-Releasing Bacterial Cellulose/Chitosan Crosslinked Hydrogels for the Treatment of Polymicrobial Wound Infections
Authors: Hasan Nurhasni , Lee Juho , Ahn Hye-Jin , Hwang Wook Ryol , Bahar Muhammad Akbar , Habibie Habibie , Amir Muhammad Nur , Lallo Subehan , Son Hong-Joo , Yoo Jin-Wook
Published: December 2021

Polymicrobial wound infections are a major cause of infectious disease-related morbidity and mortality worldwide. In this study, we prepared a nitric oxide (NO)-releasing oxidized bacterial cellulose/chitosan (BCTO/CHI) crosslinked hydrogel to effectively treat polymicrobial wound infections. Linear polyethyleneimine diazeniumdiolate (PEI/NO) was used as the NO donor. The aldehyde group of BCTO and the amine of CHI were used as crosslinked hydrogel-based materials; their high NO loading capacity and antibacterial activity on the treatment of polymicrobial-infected wounds were investigated. The blank and NO-loaded crosslinked hydrogels, namely BCTO-CHI and BCTO-CHI-PEI/NO, were characterized according to their morphologies, chemical properties, and drug loading. BCTO-CHI-PEI/NO exhibited sustained drug release over four days. The high NO loading of BCTO-CHI-PEI/NO enhanced the bactericidal efficacy against multiple bacteria compared with BCTO-CHI. Furthermore, compared with blank hydrogels, BCTO-CHI-PEI/NO has a favorable rheological property due to the addition of a polymer-based NO donor. Moreover, BCTO-CHI-PEI/NO significantly accelerated wound healing and re-epithelialization in a mouse model of polymicrobial-infected wounds. We also found that both crosslinked hydrogels were nontoxic to healthy mammalian fibroblast cells. Therefore, our data suggest that the BCTO-CHI-PEI/NO developed in this study improves the efficacy of NO in the treatment of polymicrobial wound infections.
Phytochemical Analysis, Antimicrobial and Antioxidant Properties of Thymus zygis L. and Thymus willdenowii Boiss. Essential Oils
Authors: Radi Fatima zahrae , Bouhrim Mohamed , Mechchate Hamza , Al-zahrani Mohammed , Qurtam Ashraf Ahmed , Aleissa Abdulmalik M. , Drioiche Aziz , Handaq Nadia , Zair Touriya
Published: December 2021

Essential oils (EOs) are chemical products produced by odoriferous glands from a variety of plants. These essential oils have many health benefits: antiseptic, anti-inflammatory and antimicrobial activities. So due to these medicinal properties, the present study was designed to analyze essential oils of Thymus zygis L. and Thymus willdenowii Boiss. for their chemical composition and biological activities. These two thyme species were collected from the region of Ifrane, Middle Atlas of Morocco. The EO was obtained by hydrodistillation, and the yields were 5.25% for T. zygis and 3.00% for T. willdenowii. The chemical composition of the EOs was analyzed by gas chromatography coupled with mass spectrometry (GC-MS), and the results showed that T. zygis EO is dominated by carvacrol (52.5%), o-cymene (23.14%), and thymol (9.68%), while the EO of T. willdenowii contains germacrene D (16.51%), carvacrol (16.19%), and geranyl acetate (8.35%) as major compounds. The antioxidant activity assessed by Diphenylpicrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays revealed that both EOs have excellent antioxidant activities; by DPPH it resulted in IC50 = 6.13 ± 0.11 for T. zygis and 6.78 ± 0.3 µg/mL for T. willdenowii, while the one by FRAP yielded EC50 = 2.46 ± 0.01 (T. zygis) and 5.17 ± 0.2 (T. willdenowii) µg/mL. The antimicrobial activity of the two essential oils was evaluated against six bacterial strains and five fungal strains by the disk diffusion method to determine the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and Minimum Fungicidal Concentration (MFC). The EOs revealed variable antimicrobial activities against the different tested microbial strains and showed strong antimicrobial activities, even against strains known as multi-resistant to antibiotics (Acinetobacter baumannii) at low concentrations (2 µL/mL). T. zygis EO showed the most powerful activity against all the studied bacteria, while that of T. willdenowii recorded moderate activity when tested against Shigella dysenteriae and Salmonella Typhi. With inhibition diameters that vary between 75 mm and 84 mm for concentrations of 2 µL/mL up to 12 µL/mL, S. aureus was shown to be the most sensitive to T. zygis EO. For the antifungal activity test, T. zygis EO showed the best inhibition diameters compared to T. willdenowii EO. These results showed that T. zygis EO has more powerful antioxidant and antimicrobial activities than T. willdenowii EO, therefore, we deduce that thyme EOs are excellent antioxidants, they have strong antimicrobial properties, and may in the future represent new sources of natural antiseptics that can be used in pharmaceutical and food industry.
Pistachio Nuts (Pistacia vera L.): Production, Nutrients, Bioactives and Novel Health Effects
Authors: Mandalari Giuseppina , Barreca Davide , Gervasi Teresa , Roussell Michael A. , Klein Bob , Feeney Mary Jo , Carughi Arianna
Published: December 2021

Epidemiological and clinical studies have indicated positive outcomes related to tree nut consumption. Here, we review the production, nutrient, phytochemical composition and emerging research trends on the health benefits of pistachio nuts (Pistacia vera L.). Pistachios are a good source of protein, fiber, monounsaturated fatty acids, minerals and vitamins, as well as carotenoids, phenolic acids, flavonoids and anthocyanins. Polyphenols in pistachios are important contributors to the antioxidant and anti-inflammatory effect, as demonstrated in vitro and in vivo through animal studies and clinical trials. The antimicrobial and antiviral potential of pistachio polyphenols has also been assessed and could help overcome drug resistance. Pistachio consumption may play a role in cognitive function and has been associated with a positive modulation of the human gut microbiota and beneficial effects on skin health. Pistachio polyphenol extracts may affect enzymes involved in glucose regulation and so type 2 diabetes. Taken together, these data demonstrate the health benefits of including pistachios in the diet. Further studies are required to investigate the mechanisms involved.
Systematic Review of Potential Anticancerous Activities of Erythrina senegalensis DC (Fabaceae)
Authors: Fofana Souleymane , Ouédraogo Moussa , Esposito Rafaèle Calvo , Ouedraogo Windbedema Prisca , Delporte Cédric , Van Antwerpen Pierre , Mathieu Véronique , Guissou Innocent Pierre
Published: December 2021

The objective of this study was to carry out a systematic review of the substances isolated from the African medicinal plant Erythrina senegalensis, focusing on compounds harboring activities against cancer models detailed in depth herein at both in vitro and in vivo preclinical levels. The review was conducted through Pubmed and Google Scholar. Nineteen out of the forty-two secondary metabolites isolated to date from E. senegalensis displayed interesting in vitro and/or in vivo antitumor activities. They belonged to alkaloid (Erysodine), triterpenes (Erythrodiol, maniladiol, oleanolic acid), prenylated isoflavonoids (senegalensin, erysenegalensein E, erysenegalensein M, alpinumisoflavone, derrone, warangalone), flavonoids (erythrisenegalone, senegalensein, lupinifolin, carpachromene) and pterocarpans (erybraedine A, erybraedine C, phaseollin). Among the isoflavonoids called “erysenegalensein”, only erysenealenseins E and M have been tested for their anticancerous properties and turned out to be cytotoxic. Although the stem bark is the most frequently used part of the plant, all pterocarpans were isolated from roots and all alkaloids from seeds. The mechanisms of action of its metabolites include apoptosis, pyroptosis, autophagy and mitophagy via the modulation of cytoplasmic proteins, miRNA and enzymes involved in critical pathways deregulated in cancer. Alpinumisoflavone and oleanolic acid were studied in a broad spectrum of cancer models both in vitro and in preclinical models in vivo with promising results. Other metabolites, including carpachromen, phaseollin, erybraedin A, erysenegalensein M and maniladiol need to be further investigated, as they display potent in vitro effects.
Portuguese Common Bean Natural Variation Helps to Clarify the Genetic Architecture of the Legume’s Nutritional Composition and Protein Quality
Authors: Mendes Francisco A. , Leitão Susana T. , Correia Verónica , Mecha Elsa , Rubiales Diego , Bronze Maria Rosário , Vaz Patto Maria Carlota
Published: December 2021

Common bean is a nutritious food legume widely appreciated by consumers worldwide. It is a staple food in Latin America, and a component of the Mediterranean diet, being an affordable source of protein with high potential as a gourmet food. Breeding for nutritional quality, including both macro and micronutrients, and meeting organoleptic consumers’ preferences is a difficult task which is facilitated by uncovering the genetic basis of related traits. This study explored the diversity of 106 Portuguese common bean accessions, under two contrasting environments, to gain insight into the genetic basis of nutritional composition (ash, carbohydrates, fat, fiber, moisture, protein, and resistant starch contents) and protein quality (amino acid contents and trypsin inhibitor activity) traits through a genome-wide association study. Single-nucleotide polymorphism-trait associations were tested using linear mixed models accounting for the accessions’ genetic relatedness. Mapping resolution to the gene level was achieved in 56% of the cases, with 102 candidate genes proposed for 136 genomic regions associated with trait variation. Only one marker-trait association was stable across environments, highlighting the associations’ environment-specific nature and the importance of genotype × environment interaction for crops’ local adaptation and quality. This study provides novel information to better understand the molecular mechanisms regulating the nutritional quality in common bean and promising molecular tools to aid future breeding efforts to answer consumers’ concerns.
A Comprehensive Review on Biology, Genetic Improvement, Agro and Process Technology of German Chamomile (Matricaria chamomilla L.)
Authors: Chauhan Ramesh , Singh Sanatsujat , Kumar Vikas , Kumar Ashok , Kumari Amit , Rathore Shalika , Kumar Rakesh , Singh Satbeer
Published: December 2021

German chamomile (M. chamomilla) is recognized as a star herb due to its medicinal and aromatic properties. This plant is found across a wide range of climatic and soil conditions. Both the flower heads and blue essential oils of German chamomile possess several pharmacological properties of an anti-inflammatory, antimicrobial, antiseptic, antispasmodic and sedative, etc., nature, which makes it a highly sought after herb for use in many pharma and aroma industries. Chamomile tea, prepared from its flower heads, is also a well-known herbal tea for mind and body relaxation. Though it is a high-demand herb, farmers have not adopted this plant for large scale cultivation as a crop, which could improve their livelihood, due to the high cost in flower heads harvesting, loss in over mature and immature flower heads picking during harvesting, unavailability of varieties and agrotechnologies for machine harvesting, a lack of efficient process development of oil extraction and in the lack of improved stable varieties. There are many studies that have reported on the phytochemistry and pharmacological uses of chamomile, which further explore its importance in the medicine industry. Several studies are also present in the literature on its cultivation practices and plant ecology. However, studies on breeding behavior, genetic improvement, varietal development and mechanical harvesting are scarce in German chamomile. Hence, keeping in mind various aspects of farmers’ and researchers’ interest, earlier reports on taxonomy, floral biology, processing of oil extraction, active constituents, uses, agronomy, breeding challenges and opportunities in German chamomile are summarized in this review.
Modifications of Polymers through the Addition of Ultraviolet Absorbers to Reduce the Aging Effect of Accelerated and Natural Irradiation
Authors: El-Hiti Gamal A. , Ahmed Dina S. , Yousif Emad , Al-Khazrajy Omar S. A. , Abdallh Mustafa , Alanazi Saud A.
Published: December 2021

The photooxidative degradation process of plastics caused by ultraviolet irradiation leads to bond breaking, crosslinking, the elimination of volatiles, formation of free radicals, and decreases in weight and molecular weight. Photodegradation deteriorates both the mechanical and physical properties of plastics and affects their predicted life use, in particular for applications in harsh environments. Plastics have many benefits, while on the other hand, they have numerous disadvantages, such as photodegradation and photooxidation in harsh environments and the release of toxic substances due to the leaching of some components, which have a negative effect on living organisms. Therefore, attention is paid to the design and use of safe, plastic, ultraviolet stabilizers that do not pose a danger to the environment if released. Plastic ultraviolet photostabilizers act as efficient light screeners (absorbers or pigments), excited-state deactivators (quenchers), hydroperoxide decomposers, and radical scavengers. Ultraviolet absorbers are cheap to produce, can be used in low concentrations, mix well with polymers to produce a homogenous matrix, and do not alter the color of polymers. Recently, polyphosphates, Schiff bases, and organometallic complexes were synthesized and used as potential ultraviolet absorbers for polymeric materials. They reduced the damage caused by accelerated and natural ultraviolet aging, which was confirmed by inspecting the surface morphology of irradiated polymeric films. For example, atomic force microscopy revealed that the roughness factor of polymers’ irradiated surfaces was improved significantly in the presence of ultraviolet absorbers. In addition, the investigation of the surface of irradiated polymers using scanning electron microscopy showed a high degree of homogeneity and the appearance of pores that were different in size and shape. The current work surveys for the first time the use of newly synthesized, ultraviolet absorbers as additives to enhance the photostability of polymeric materials and, in particular, polyvinyl chloride and polystyrene, based mainly on our own recent work in the field.
Comparison of Real and Simulated Fiber Orientations in Injection Molded Short Glass Fiber Reinforced Polyamide by X-ray Microtomography
Authors: Żurawik Rafał , Volke Julia , Zarges Jan-Christoph , Heim Hans-Peter
Published: December 2021

During injection molding of short glass fiber reinforced composites, a complex structure is formed due to the fiber movement. The resulting fiber orientation can be predicted using various simulation models. However, the models are known to have inadequacies andthe influence of process and model parameters is not clearly and comprehensively described. In this study, the aforementioned model and process parameters are investigated to determine the dependencies of the individual influences on the real and simulated fiber orientation. For this purpose, specimens are injection molded at different process parameters. Representative regions of the specimens are measured using X-ray microtomography and dynamic image analysis to determine the geometric properties of the fibers as well as their orientations. Furthermore, simulations are performed with the simulation software Moldflow® using different mesh types and densities as well as varying parameters of the MRD model to represent the real fiber orientations. The results show that different orientation areas arise in the samples, which cannot be represented with a simulation varying only one parameter. Several simulations must be carried out in order to represent flow regions occurring in the specimen as realistically as possible.
Effects of Raw Material Source on the Properties of CMC Composite Films
Authors: Yao Yao , Sun Zhenbing , Li Xiaobao , Tang Zhengjie , Li Xiaoping , Morrell Jeffrey J. , Liu Yang , Li Chunli , Luo Zhinan
Published: December 2021

Sodium carboxymethyl cellulose (CMC) can be derived from a variety of cellulosic materials and is widely used in petroleum mining, construction, paper making, and packaging. CMCs can be derived from many sources with the final properties reflecting the characteristics of the original lignocellulosic matrix as well as the subsequent separation steps that affect the degree of carboxy methyl substitution on the cellulose hydroxyls. While a large percentage of CMCs is derived from wood pulp, many other plant sources may produce more attractive properties for specific applications. The effects of five plant sources on the resulting properties of CMC and CMC/sodium alginate/glycerol composite films were studied. The degree of substitution and resulting tensile strength in leaf-derived CMC was from 0.87 to 0.89 and from 15.81 to 16.35 MPa, respectively, while the degree of substitution and resulting tensile strength in wooden materials-derived CMC were from 1.08 to 1.17 and from 26.08 to 28.97 MPa, respectively. Thus, the degree of substitution and resulting tensile strength tended to be 20% lower in leaf-derived CMCs compared to those prepared from wood or bamboo. Microstructures of bamboo cellulose, bamboo CMC powder, and bamboo leaf CMC composites’ films all differed from pine-derived material, but plant source had no noticeable effect on the X-ray diffraction characteristics, Fourier transform infrared spectroscopy spectra, or pyrolysis properties of CMC or composites films. The results highlighted the potential for using plant source as a tool for varying CMC properties for specific applications.
Comparative Study on UV-AOPs for Efficient Continuous Flow Removal of 4-tert-Butylphenol
Authors: Mergenbayeva Saule , Poulopoulos Stavros G.
Published: December 2021

In the present study, UV-light-driven advanced oxidation processes (AOPs) have been employed for the degradation of 4-tert-Butylphenol (4-t-BP) in water under continuous flow conditions. The effects of varying space time (10, 20, 40, 60 and 120 min) and oxidant dosage (88.3 mg/L, 176.6 mg/L and 264 mg/L) were examined. 4-t-BP degradation efficiency in the UV-induced AOPs followed the order of UV/H2O2 (264.9 mg/L) ≈ UV/Fe2+/H2O2 > UV/Fe3+/H2O2 > UV/H2O2 (176.6 mg/L) > UV/H2O2 (88.3 mg/L) > UV/Fe-TiO2 > UV/TiO2 > UV, while UV/Fe3+/H2O2 was the most efficient process in terms of Total Organic Carbon (TOC) removal (at the space time of 60 min) among those tested. The combination of UV with 88.3 mg/L H2O2 enhanced pollutant removal from 51.29% to 93.34% after 10 min of irradiation. The presence of H2O2 contributed to the highest 4-t-BP and TOC removal values. Interestingly, the increase in space time from 20 to 60 min resulted in surpassing of the activity of the Fe-TiO2 over commercial TiO2, although it had an almost negligible positive impact on the performance of the UV/H2O2 system as well as H2O2 concentration. The results obtained showed that more than 80% of 4-t-BP could be successfully degraded by both heterogeneous and homogeneous AOPs after 60 min.
Effect of Drying Techniques on the Physical, Functional, and Rheological Attributes of Isolated Sunflower Protein and Its Hydrolysate
Authors: Dabbour Mokhtar , Sami Rokkaya , Mintah Benjamin K. , He Ronghai , Wahia Hafida , Khojah Ebtihal , Petkoska Anka Trajkovska , Fikry Mohammad
Published: December 2021

The influence of freeze and convection (at 40 and 50 °C) drying on the physical, functional, and rheological attributes of sunflower protein (SP) and its hydrolysate (SPH) was investigated. Compared with convectively-dried samples, the lightness, turbidity, bulk density, and particle size values of the freeze-dried SP and SPH were substantially higher, but the browning index was lower (p < 0.05). Additionally, freeze-dried samples exhibited good solubility and foaming characteristics, whereas lower emulsion properties with the most pH values were observed. Furthermore, SPHs possessed higher solubility as well as foamability over SPs under varying pH values (2.0–10.0), whilst reduction in the emulsion activity index was clearly observed (p < 0.05). Convectively-dried powders exhibited greater viscosity and consistency coefficient; and significantly lower flow behavior index of dispersions, relative to the respective freeze-dried preparations, indicating that dehydration methods influenced the flow behavior of the investigated samples. From a molecular weight analysis, convectively-dried samples at various temperatures were characterized with high proportion of small-sized particles at ≤1 kDa fractions over the respective powders obtained by freeze drying. The observations made, thus, would benefit food processors and manufacturers in electing better dehydration technique based on the desired traits of SP and SPH powders for successful application in food product formulations.
Sexual Dysfunction in Schizophrenia: A Narrative Review of the Mechanisms and Clinical Considerations
Authors: Edinoff Amber N. , Nix Catherine A. , Fort Juliana M. , Kimble Jeanna , Guedry Ryan , Thomas George , Cornett Elyse M. , Kaye Adam , Kaye Alan D.
Published: December 2021

Psychiatric disorders, in general, have a high prevalence of sexual problems, whether from the psychopathology of the disorder itself, pre-existing or co-morbid sexual disorder or from side effects of the treatment for mental disorders. Many patients report an already existing sexual dysfunction at the onset of diagnosis. The risk association for developing sexual dysfunction in patients with schizophrenia includes antipsychotic use and resulting hyperprolactinemia, age, gender, and disease severity. Medication side effects lead to nonadherence, and relapses lead to structural changes in the brain, treatment resistance, and worsening of symptoms. Findings in certain studies propose serum prolactin and thyroid-stimulating hormone measurement as a tool for assessing patients with schizophrenia for sexual dysfunction. Regarding specific symptoms, females especially reported decreased desire at baseline and galactorrhea after treatment. The findings of this review, therefore, suggest that sexual dysfunction may be present in patients with schizophrenia before starting antipsychotic treatment and that patients, especially those who are female, are likely to develop hyperprolactinemia with antipsychotic treatment. Aripiprazole may be an emergent treatment for sexual dysfunction in those who use antipsychotics. It is important for patients to consider sexual dysfunction prior to prescribing antipsychotics. Since sexual dysfunction can impact a patient’s quality of life and affect treatment adherence, it is important for physicians to be aware and monitor patients for symptoms.
A Robot Arm Design Optimization Method by Using a Kinematic Redundancy Resolution Technique
Authors: Maaroof Omar W. , Dede Mehmet İsmet Can , Aydin Levent
Published: December 2021

Redundancy resolution techniques have been widely used for the control of kinematically redundant robots. In this work, one of the redundancy resolution techniques is employed in the mechanical design optimization of a robot arm. Although the robot arm is non-redundant, the proposed method modifies robot arm kinematics by adding virtual joints to make the robot arm kinematically redundant. In the proposed method, a suitable objective function is selected to optimize the robot arm’s kinematic parameters by enhancing one or more performance indices. Then the robot arm’s end-effector is fixed at critical positions while the redundancy resolution algorithm moves its joints including the virtual joints because of the self-motion of a redundant robot. Hence, the optimum values of the virtual joints are determined, and the design of the robot arm is modified accordingly. An advantage of this method is the visualization of the changes in the manipulator’s structure during the optimization process. In this work, as a case study, a passive robotic arm that is used in a surgical robot system is considered and the task is defined as the determination of the optimum base location and the first link’s length. The results indicate the effectiveness of the proposed method.
Estimation of the All-Wave All-Sky Land Surface Daily Net Radiation at Mid-Low Latitudes from MODIS Data Based on ERA5 Constraints
Authors: Li Shaopeng , Jiang Bo , Peng Jianghai , Liang Hui , Han Jiakun , Yao Yunjun , Zhang Xiaotong , Cheng Jie , Zhao Xiang , Liu Qiang , Jia Kun
Published: December 2021

The surface all-wave net radiation (Rn) plays an important role in the energy and water cycles, and most studies of Rn estimations have been conducted using satellite data. As one of the most commonly used satellite data sets, Moderate Resolution Imaging Spectroradiometer (MODIS) data have not been widely used for radiation calculations at mid-low latitudes because of its very low revisit frequency. To improve the daily Rn estimation at mid-low latitudes with MODIS data, four models, including three models built with random forest (RF) and different temporal expansion models and one model built with the look-up-table (LUT) method, are used based on comprehensive in situ radiation measurements collected from 340 globally distributed sites, MODIS top-of-atmosphere (TOA) data, and the fifth generation of European Centre for Medium-Range Weather Forecasts Reanalysis 5 (ERA5) data from 2000 to 2017. After validation against the in situ measurements, it was found that the RF model based on the constraint of the daily Rn from ERA5 (an RF-based model with ERA5) performed the best among the four proposed models, with an overall validated root-mean-square error (RMSE) of 21.83 Wm−2, R2 of 0.89, and a bias of 0.2 Wm−2. It also had the best accuracy compared to four existing products (Global LAnd Surface Satellite Data (GLASS), Clouds and the Earth’s Radiant Energy System Edition 4A (CERES4A), ERA5, and FLUXCOM_RS) across various land cover types and different elevation zones. Further analyses illustrated the effectiveness of the model by introducing the daily Rn from ERA5 into a “black box” RF-based model for Rn estimation at the daily scale, which is used as a physical constraint when the available satellite observations are too limited to provide sufficient information (i.e., when the overpass time is less than twice per day) or the sky is overcast. Overall, the newly-proposed RF-based model with ERA5 in this study shows satisfactory performance and has strong potential to be used for long-term accurate daily Rn global mapping at finer spatial resolutions (e.g., 1 km) at mid-low latitudes.
Fast Urban Land Cover Mapping Exploiting Sentinel-1 and Sentinel-2 Data
Authors: Petrushevsky Naomi , Manzoni Marco , Monti-Guarnieri Andrea
Published: December 2021

The rapid change and expansion of human settlements raise the need for precise remote-sensing monitoring tools. While some Land Cover (LC) maps are publicly available, the knowledge of the up-to-date urban extent for a specific instance in time is often missing. The lack of a relevant urban mask, especially in developing countries, increases the burden on Earth Observation (EO) data users or requires them to rely on time-consuming manual classification. This paper explores fast and effective exploitation of Sentinel-1 (S1) and Sentinel-2 (S2) data for the generation of urban LC, which can be frequently updated. The method is based on an Object-Based Image Analysis (OBIA), where one Multi-Spectral (MS) image is used to define clusters of similar pixels through super-pixel segmentation. A short stack (<2 months) of Synthetic Aperture Radar (SAR) data is then employed to classify the clusters, exploiting the unique characteristics of the radio backscatter from human-made targets. The repeated illumination and acquisition geometry allows defining robust features based on amplitude, coherence, and polarimetry. Data from ascending and descending orbits are combined to overcome distortions and decrease sensitivity to the orientation of structures. Finally, an unsupervised Machine Learning (ML) model is used to separate the signature of urban targets in a mixed environment. The method was validated in two sites in Portugal, with diverse types of LC and complex topography. Comparative analysis was performed with two state-of-the-art high-resolution solutions, which require long sensing periods, indicating significant agreement between the methods (averaged accuracy of around 90%).
Nutritional and Physiological Constraints Contributing to Limitations in Small Intestinal Starch Digestion and Glucose Absorption in Ruminants
Authors: Trotta Ronald J. , Harmon David L. , Matthews James C. , Swanson Kendall C.
Published: December 2021

Increased efficiency of nutrient utilization can potentially be gained with increased starch digestion in the small intestine in ruminants. However, ruminants have quantitative limits in the extent of starch disappearance in the small intestine. The objective is to explore the nutritional and physiological constraints that contribute to limitations of carbohydrate assimilation in the ruminant small intestine. Altered digesta composition and passage rate in the small intestine, insufficient pancreatic α-amylase and/or small intestinal carbohydrase activity, and reduced glucose absorption could all be potentially limiting factors of intestinal starch assimilation. The absence of intestinal sucrase activity in ruminants may be related to quantitative limits in small intestinal starch hydrolysis. Multiple sequence alignment of the sucrase-isomaltase complex gives insight into potential molecular mechanisms that may be associated with the absence of intestinal sucrase activity, reduced capacity for intestinal starch digestion, and limitations in the efficiency of feed utilization in cattle and sheep. Future research efforts in these areas will aid in our understanding of small intestinal starch digestion and glucose absorption to optimize feeding strategies for increased meat and milk production efficiency.
Heart Rate Modeling and Prediction Using Autoregressive Models and Deep Learning
Authors: Staffini Alessio , Svensson Thomas , Chung Ung-il , Svensson Akiko Kishi
Published: December 2021

Physiological time series are affected by many factors, making them highly nonlinear and nonstationary. As a consequence, heart rate time series are often considered difficult to predict and handle. However, heart rate behavior can indicate underlying cardiovascular and respiratory diseases as well as mood disorders. Given the importance of accurate modeling and reliable predictions of heart rate fluctuations for the prevention and control of certain diseases, it is paramount to identify models with the best performance in such tasks. The objectives of this study were to compare the results of three different forecasting models (Autoregressive Model, Long Short-Term Memory Network, and Convolutional Long Short-Term Memory Network) trained and tested on heart rate beats per minute data obtained from twelve heterogeneous participants and to identify the architecture with the best performance in terms of modeling and forecasting heart rate behavior. Heart rate beats per minute data were collected using a wearable device over a period of 10 days from twelve different participants who were heterogeneous in age, sex, medical history, and lifestyle behaviors. The goodness of the results produced by the models was measured using both the mean absolute error and the root mean square error as error metrics. Despite the three models showing similar performance, the Autoregressive Model gave the best results in all settings examined. For example, considering one of the participants, the Autoregressive Model gave a mean absolute error of 2.069 (compared to 2.173 of the Long Short-Term Memory Network and 2.138 of the Convolutional Long Short-Term Memory Network), achieving an improvement of 5.027% and 3.335%, respectively. Similar results can be observed for the other participants. The findings of the study suggest that regardless of an individual’s age, sex, and lifestyle behaviors, their heart rate largely depends on the pattern observed in the previous few minutes, suggesting that heart rate can be reasonably regarded as an autoregressive process. The findings also suggest that minute-by-minute heart rate prediction can be accurately performed using a linear model, at least in individuals without pathologies that cause heartbeat irregularities. The findings also suggest many possible applications for the Autoregressive Model, in principle in any context where minute-by-minute heart rate prediction is required (arrhythmia detection and analysis of the response to training, among others).