bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of Deep Convolutional Neural Network with the Integrated Batch Normalization and Global pooling
Authors: K K Priyanga , S Sabeen
Published: July 2023

Deep convolutional neural networks (DCNN) have made significant progress in a wide range of applications in recent years, which include image identification, audio recognition, and translation of machine information. These tasks assist machine intelligence in a variety of ways. However, because of the large number of parameters, float manipulations and conversion of machine terminal remains difficult. To handle this issue, optimization of convolution in the DCNN is initiated that adjusts the characteristics of the neural network, and the loss of information is minimized with enriched performance. Minimization of convolution function addresses the optimization issues. Initially, batch normalization is completed, and instead of lowering neighborhood values, a full feature map is minimized to a single value using the global pooling approach. Traditional convolution is split into depth and pointwise to decrease the model size and calculations. The optimized convolution-based DCNN's performance is evaluated with the assistance of accuracy and occurrence of error. The optimized DCNN is compared with the existing state-of-the-art techniques, and the optimized DCNN outperforms the existing technique.
Мифологический образ моста в литературе и его интерпретации на примере мостов Санкт-Петербурга
Authors: Орловская Т.О.
Published: July 2023

Мост – одно из древнейших инженерных сооружений, возводимых с незапамятных времен, и, хотя его утилитарная функция остается неизменной и проявляется прежде всего в преодолении препятствий, к примеру, водоемов или оврагов, мифологического сознание древнего человека наделило его целым рядом функций. Данная статья посвящена рассмотрению образа моста в литературе как мифологического символа, определяющего хронотоп «сакрального»; символа-связки мира живых с миром мертвых; символа перехода.
Game theory model of corporate governance: Fitting real market environment
Authors: Zhu Yunxuan
Published: July 2023

This paper uses two game models to fit the market subject behavior in corporategovernance from the dynamic and static dimensions. Further expanding the maingovernance subjects and adding variables with practical significance, suchas "bribery" and "social welfare," into the game theory model, some conclusions withpractical significance are found in this paper. For example, the factors such as thepossibility of checking out manager's violation, the punishment of the irregularities, and the supervision cost of the supervisory board, have an essential impact onthebehavior of corporate governance. In the static game model, this paper finds that intersubjective games and restrictions prevent “the worst result” fromoccurring. Besides, social welfare even can be improved under certain conditions. Inthemulti-coexistence game model, the equilibrium point of the static game model is uncertain, which makes the social welfare situation uncertain. The conclusions of thegame models can be used for reference to improve the corporate governancemechanism.

JEL classification: G30; M10; D21; D81
Modification of substrate specificity of L-arginine oxidase for detection of l-citrulline
Authors: Yamamoto Kei , Masakari Yosuke , Araki Yasuko , Ichiyanagi Atsushi , Ito Kotaro
Published: July 2023

Enzymatic detection of citrulline, a potential biomarker for various diseases, is beneficial. However, determining citrulline levels requires expensive instrumental analyses and complicated colorimetric assays. Although L-amino acid oxidase/dehydrogenase is widely used to detect l-amino acids, an l-citrulline-specific oxidase/dehydrogenase has not been reported. Therefore, in this study, we aimed to develop an l-citrulline-specific enzyme by introducing a mutation into l-arginine oxidase (ArgOX) derived from Pseudomonas sp. TPU 7192 to provide a simple enzymatic l-citrulline detection system. The ratio of the oxidase activity against l-arginine to that against l-citrulline (Cit/Arg) was 1.2%, indicating that ArgOX could recognize l-citrulline as a substrate. In the dehydrogenase assay, the specific dehydrogenase activity towards l-arginine was considerably lower than the specific oxidase activity. However, the specific dehydrogenase activity towards l-citrulline was only slightly lower than the oxidase activity, resulting in improved substrate specificity with a Cit/Arg ratio of 49.5%. To enhance the substrate specificity of ArgOX, we performed site-directed mutagenesis using structure-based engineering. The 3D model structure indicated that E486 interacted with the l-arginine side chain. By introducing the E486 mutation, the specific dehydrogenase activity of ArgOX/E486Q for l-citrulline was 3.25 ± 0.50 U/mg, which was 3.8-fold higher than that of ArgOX. The Cit/Arg ratio of ArgOX/E486Q was 150%, which was higher than that of ArgOX. Using ArgOX/E486Q, linear relationships were observed within the range of 10–500 µM l-citrulline, demonstrating its suitability for detecting citrulline in human blood. Consequently, ArgOX/E486Q can be adapted as an enzymatic sensor in the dehydrogenase system.
Readmissions to a Nephrology Service in Abidjan: Prevalence and Risk Factors
Authors: Konan Serge Didier , Diopoh Sery Patrick Olivier , Ouattara Kolo Claude , Kouadio Marie Dominique , Yeo Donafologo Drissa , Yao Kouamé Hubert
Published: July 2023

Background : Readmission of patients with kidney disease is a reality in our practice setting.
Objectives : To assess the prevalence of readmission and identify factors associated with readmission and death of readmitted patients.
Materials and methods : This was a retrospective study conducted from the 1st of October 2017 to the 31st of December 2019 in the nephrology department of Treichville Teaching Hospital.
Results : During the study period, 1142 patients were admitted, of whom 154 patients were readmitted, representing a prevalence of 13.48%. The mean age of the patients was 42.31 [15 ;77 years] and the sex ratio was 1.35 in favour of men. The unemployed were the most represented (24.78%).
The average time between hospitalisations was 28.23 +/- 21.83 days [3; 123 days]. Patients were readmitted within 30 days of discharge in 65.48% of cases, between 30 and 60 days in 23.90% and after 60 days in 10.62%. Uremic syndrome was the main reason for readmission (68, 14%). The causes of readmission were dominated by dialysis failure (82.30%), followed by complications of vascular access, notably dialysis catheter infection (10.60%). Mortality was 30.97%. Obstructive nephropathy (p=0.029) and hypocalcaemia (p=0.030) were associated with the risk of hospital mortality. Severe anaemia was associated with early readmission (p=0.047) and hypertension with the risk of non-early readmission.
Conclusion : The prevalence of readmission at hospital is high. The causes are dominated by dialysis failure and dialysis catheter infection. Hence the interest in improving accessibility to dialysis for patients and raising awareness on prevention and management of risk factors of chronic kidney disease.
Synthesis, Characterization and Application of Potassium Incorporated Nitrogenous Nano Fertilizer
Authors: Sebastian Ardra , Devika P S , Nair Praseetha P , Devadas V S
Published: July 2023

Nano fertilizers have emerged as promising alternative smart fertilizers to ensure high crop production and soil restoration. In this study, we aimed to synthesize an eco-friendly and feasible potassium-incorporated nitrogenous nano fertilizer using physical and chemical methods. The synthesized nano fertilizers were characterized using Carbon, Hydrogen, Nitrogen and Sulphur (CH-NS) Elemental Analyzer, Inductively Coupled Plasma Mass Spectrometry (ICP-MS), Scanning Electron Microscopy (SEM), and Dynamic Light Scattering (DLS) techniques. Based on the results, a suitable product was selected for preliminary trials in plant nutrition. The most essential nutrients for crops are macronutrients, such as nitrogen, phosphorus, and potassium. In the chemical synthesis, the nano fertilizer was prepared by extracting nutrients from ripe banana fruit rind (peels) and leaf extracts using chitosan nanoparticles, which served as a useful matrix for loading nutrients into crops. Subsequently, the synthesized nano fertilizer was analyzed, which revealed a particle size of 293 nm and a maximum nitrogen content of 3.51% and potassium content of 4.47%. For the physical synthesis, a planetary ball mill was used, where chitosan and potassium carbonate obtained from banana peel ash were ball milled to reduce their size. The results indicated a particle size of 5308 nm; a maximum nitrogen content of 5.55% and potassium content of 3.01%. After comparing both outcomes, the fertilizer synthesized using the chemical method was chosen for analyzing its effect on plant growth. Trials with crop plants demonstrated that the growth rates of plants increased with a decrease in the dosage of the nano fertilizer. Further elaborative field trials with different crops are suggested to evolve commercial recommendations to farmers.
High-resolution sequence stratigraphy from well-log patterns and base-level variations of the Paleocene - Early Eocene N’kapa Formation, Douala onshore Basin (SW Cameroon)
Authors: LEBOGO Serge Parfait KOAH NA , BISSO Dieudonné , ESSI Mike-Franck MIENLAM , MBESSE Cécile Olive
Published: July 2023

The present study aims to establish the stratigraphic architecture in order to understand the depositional history during the Paleocene- Early Eocene interval in the Douala Onshore Basin. The sequence stratigraphic analysis from gamma-ray logs and well cuttings was used to define stratigraphic surfaces and systems tracts based on the depositional sequence model. The results obtained show that the Paleocene-Early Eocene interval could be subdivided into three lithostratigraphic units (Unit 1, Unit 2, and Unit 3) of Middle Paleocene - Late Paleocene, Late Paleocene - Early Eocene, and Early Eocene age respectively. The sequence stratigraphic interpretation revealed three major stratigraphic surfaces : the sequence boundary (SB1) of the Middle Paleocene top, the transgressive surface (TS2) of the Late Paleocene, and the maximum flooding surface (MFS2) of the Early Eocene. The first highstand systems tracts (HST1) of the Middle Paleocene, the lowstand systems tract (LST2) of the Late Paleocene, the transgressive systems tract (TST2) of the Late Paleocene to Early Eocene, and the second highstand systems tracts (HST2) of the Early Eocene are the depositional sequences observed. The Paleocene-Eocene interval is therefore globally prograding, interrupted by a short transgressive episode of Late Paleocene to Early-Eocene age. Three cycles of base-level have been identified: the first cycle of base-level fall dated Middle Paleocene, the second cycle of rapid base-level rise which occurred between Late Paleocene to Early Eocene, and the third cycle of base-level fall dated Early Eocene. This observation confirms that the main factor which influenced the depositional history of Paleocene- Early Eocene succession in the Douala Onshore Basin was the eustatic sea-level changes due to the Cenozoic post-rift subsidence of the West African margin.
Docking, Synthesis and Evaluation of 4-hydroxy-1-phenyl-2(1H)-quinolone
Derivatives as Anticancer Agents
Authors: Tendulkar Chaitali Prabhu , Dessai Prachita Gauns , Mamle Desai Shivlingrao , Kadam Amrita
Published: July 2023

Background:

The estimated number of cancer cases in India for the year 2022 was found to be 14,61,427. The development of chemotherapeutic agents has reduced the mortality rate, however,they have high toxicity which is a disadvantage. Many researchers have found out that quinolin-2-one possesses anticancer activity, with this background we thought of synthesizing the quinolin-2-one derivatives.

Objective:

This study aimed to carry out docking, synthesis, characterization, and evaluation of 2-(2-(4-Hydroxy-2-oxoquinolin-1(2H)-yl)phenyl/ substituted phenyl)-3-(phenylamino) thiazolidon-4-one derivatives (IVa-g) as an anticancer agent.

Method:

Diphenylamine and malonic acid treated with phosphoryl chloride gave compound I, which on formylation afforded compound II, which on reaction with various substituted aromatic phenylhydrazine derivatives gave compounds IIIa-g, which on further reaction with thioglycolic acid and anhydrous zinc chloride yielded the compounds IVa-g.

Result:

Among all the synthesized novel derivatives, compounds IV a-d showed 50% lysis in the IC50 range of 25-50µg for the A549 cell line, and compounds IVa, and IVb showed 50% lysis in the IC50 range of 25-50µg for the MDA-MB cell line. The compound, 3-((4-fluorophenyl)amino)-2-(2-(4-hydroxy-2-oxoquinolin-1(2H)-yl)phenyl)thiazolidin-4-one (IVg) was found to be the most active against both the cell line, A549 and MDA-MB with IC50 value of 0.0298µmol and 0.0338µmol respectively. The docking results revealed that the synthesized compounds exhibited well-conserved hydrogen bonding with one or more amino acid residues in the active pocket of EGFR tyrosine kinase domain with 4-anilinoquinazoline inhibitor erlotinib (PDB ID:1M17). Compound IVg showed the highest MolDock score of -137.813 compared to the standard drug Imatinib having a MolDock score of -119.354.

Conclusion:

Compound IVg showed the highest MolDock score and was also found to be most potent against both the cell line, A549, and MDA-MB.
Enhancement of Monacolin K Production by Intergeneric Hybridization between Monascus purpureus (Arg-) and Monascus ruber (Thi-, Met-) Auxotrophs
Authors: Sinha Anindita , Sarkar Keka
Published: July 2023

This study aims to reconcile industrially suitable strains of higher red pigment producing Monascus purpureus MPA5 and higher Monacolin K producing Monascus ruber MRA7, were tried to fuse for development of increased efficacy of targeted secondary metabolites production. The optimum concentration of protoplast mixture was standardized, before the fusion experiment. The effective fusion was observed with the solution of 30 % PEG 6000, CaCl2.2H2O (0.01 M) and glycine (0.05 M). Colonies of the fusants were segregated using complete medium. The fusants were irradiated under UV- light in LD50 dose. On the basis of non-segregation of colony appearance after repeated subculturing in complete medium, 8 colonies were selected. Finally, one of the stable fusant MF11 grew more rapidly than one of the parental strain M. purpureus MPA5, but not as fast as M. ruber MRA7, were selected and grown on low grade rice as solid substrate for production of metabolites. Production of red pigments, alpha-amylase and acid protease were at intermediate stage between two parental strains but enhancement of Monacolin K was observed. High performance liquid chromatography (HPLC) analysis was revealed that Monacolin K content was increased as much as two and half times than the parents. No fluorescent yellow band was detected in TLC plate, indicating of citrinin negativity of the fusant MF11. It is the first report of enhanced Monacolin K production by a stable fusant of Monascus sp.
Physics-Informed Neural Networks for fault slip monitoring: simulation, frictional parameter estimation, and prediction on slow slip events in a spring-slider system
Authors: Fukushima Rikuto , Kano Masayuki , Hirahara Kazuro
Published: July 2023

The episodic transient fault slips called slow slip events (SSEs) have
been observed in many subduction zones. These slips often occur in
regions adjacent to the seismogenic zone during the interseismic period,
making monitoring SSEs significant for understanding large earthquakes.
Various fault slip behaviors, including SSEs and earthquakes, can be
explained by the spatial heterogeneity of frictional properties on the
fault. Therefore, estimating frictional properties from geodetic
observations and physics-based models is crucial for fault slip
monitoring. In this study, we propose a Physics-Informed Neural Network
(PINN)-based new approach to simulate fault slip evolutions, estimate
frictional parameters from observation data, and predict subsequent
fault slips. PINNs, which integrate physical laws and observation data,
represent the solution of physics-based differential equations. As a
first step, we validate the effectiveness of the PINN-based approach
using a simple single-degree-of-freedom spring-slider system to model
SSEs. As a forward problem, we successfully reproduced the temporal
evolution of SSEs using PINNs and indicated how we should choose the
appropriate collocation points depending on the residuals of
physics-based differential equations. As an inverse problem, we
estimated the frictional parameters from synthetic observation data and
demonstrated the ability to obtain accurate values regardless of the
choice of first-guess values. Furthermore, we discussed the potential of
the predictability of the subsequent fault slips using limited
observation data, taking into account uncertainties. Our results
indicate the significant potential of PINNs for fault slip monitoring.
PRODUKTIVITAS ALAT BERAT PADA GALIAN DAN TIMBUNAN
Authors: Nuzola Ma'ruf , Herni Mas , Kurniawan Septyanto
Published: July 2023

Total pekerjaan alat berat adalah 14.118 m3 yang terdiri dari pekerjaan galian sebesar 13.020 dan pekerjaan timbunan sebesar 1.098. Untuk produktivitas Excavator SANY SY305 116,64 m3/ jam (menggali dan memuat kedalam Dumptruck), Excavator SANY SY365 233,29 m3/ jam (menggali dan memuat kedalam Dumptruck), Bulldozer D85ESS-2 369,40 m3/ jam (menggusur dan mendorong atau memindahkan tanah), Vibratorry Roller SAKAI SV515D 159,75 m3/ jam (menggilas dan memadatkan), Dumptruck kapasitas 24 dan 30 m3. 6,91 m3/ jam (galian 1), 14,85 m3/ jam (galian 2), 21,87  m3/  jam  (timbunan).  Analisa  biaya  sewa  alat  menggunakan  satuan harga sewa yang ada dilokasi penlitian.

Untuk hasil perhitungan analisis lapangan didapat penggunaan biaya alat berat untuk pekerjaan galian dan timbunan membutuhkan waktu 100 jam, dengan biaya sewa alat berat sebesar 629.200.000. Dari hasil perhitungan alternatif 1 didapatkan alat berat membutuhkan waktu 95 jam dengan mengerjakan pekerjaan dengan volume yang ada dilapangan, dengan total biaya sewa alat berat sebesar 597.075.000, sedangkan dari hasil perhitungan alternatif  2  didapatkan  waktu  204  jam  dengan  total  biaya  sewa  sebesar 1.257.660.000. Untuk hasil tanah galian yang tidak terpakai akan diangkut ke lokasi   pembuangan   sedangkan   tanah   yang   terpakai   digunakan   untuk timbunan dinding muka apron hulu.
La inocencia mestiza en tiempos de la 4T
Authors: Saldivar Tanaka Emiko
Published: July 2023

Una característica de la ideología del mestizaje es negar el racismo. La desigualdad y el privilegio racial se hacen difusos por medio de un esfuerzo constante por validar y rescatar el discurso hegemónico que, bajo el mestizaje, sostiene que el conflicto racial está resuelto. Aquí presento tres estrategias que atestiguan cómo la sociedad mestiza responde en momentos en que el conflicto racial –el racismo anti-indígena en este caso, se hace visible–. Exploro cómo se traducen en mecanismos de “regulación moral” de las relaciones sociales (Corrigan, & Sayer, 1985). El primer mecanismo lo defino como “inocencia mestiza”, el segundo es una respuesta desde la “fragilidad mestiza” y, por último, el tercero, lo identifico como mestizaje neo-populista, como una versión renovada del proyecto mestizo del siglo xx.
Peranan Kearifan Lokal (Local Wisdom) dalam Menjaga Keseimbangan Alam (Cerminan Masyarakat Adat Ammatoa di Kajang)
Authors: Nurlidiawati Nurlidiawati , Ramadayanti Ramadayanti
Published: July 2023

Penelitian ini mengkaji tentang peranan kearifan lokal (local wisdom) dalam menjaga keseimbangan alam (cerminan masyarakat adat Ammatoa Kajang). Terjadi kerusakan di mana-mana akibat tangan-tangan dan perbuatan manusia yang tidak bertanggungjawab. Hal tersebut disampaikan oleh Allah Swt. melalui ayat-ayat Alquran, ditambah dengan munculnya sebuah periode yang dikenal dengan globalisasi dan modernisasi. Kondisi ini membuat manusia tidak lagi memikirkan keselamatan dan keseimbangan alam sekitarnya. Namun berbeda dengan beberapa komunitas di wilayah-wilayah tertentu di Indonesia, salah satunya adalah komuitas masyarakat adat Ammatoa Kajang yang sampai hari ini tetap melestarikan dan menjaga keseimbangan alam di kawasan adat Ammato. Terdapat tiga masalah sebagai fokus kajian utama yakni bagaimana hubungan kearifan lokal dengan pelestarian lingkungan, bagaimana bentuk-bentuk kearifan lokal masyarakat adat Ammatoa, dan bagaimana perilaku masyarakat adat Ammatoa terhadap lingkungan alam sekitarnya. Sebagai tujuan dalam penelitian ini adalah untuk mengetahui dan mendeskripsikan hubungan antara kearifan lokal dengan pelestarian lingkungan, untuk mengetahui bentuk-bentuk kearifan lokal masyarakat adat Ammatoa, serta mengetahui dan menganalisis perilaku masyarakat adat Ammatoa terhadap lingkungan alam sekitarnya.
Grondslagen Van De Fysica
Authors: De Markiezin van Chastellet Émilie
Published: July 2023

De Institutions Physiques van Mw. De Markiezin van Chastellet, hier vertaald als Grondslagen van de fysica, werd gepubliceerd in 1742, als uitgebreide en verbeterde uitgave van een eerdere editie uit 1740. Daarin geeft zij een uitvoerig en deskundig overzicht van de natuurfilosofie en natuurkunde van haar tijd, gebaseerd op inzichten van Descartes, Kepler, Galileo, Huygens, Leibniz en Newton, naast die van vele tijdgenoten die de nieuwe wetenschap hielpen vormgeven. Zij geeft daarop haar persoonlijke visie en verdedigt als een van de eersten het belang van het begrip bewegingsenergie, of in haar terminologie: levende kracht, als grondslag voor een algemene dynamica. Samen met haar complete vertaling van en commentaar op Newtons Principia getuigt dit boek van haar status als erkend geleerde in een tijd waarin de Verlichting in Frankrijk tot bloei kwam. Haar persoonlijke geschiedenis, waarin haar geliefde en beschermeling Voltaire een centrale plaats innam, getuigt van moed en ambitie die, zoals Margriet van der Heijden in haar inleiding beschrijft, zelfs voor een vrouw van haar afkomst en stand uitzonderlijk was. Dit boek werd al direct na verschijnen in het Duits en Italiaans vertaald, en speelde zodoende een niet onbelangrijke rol bij de verspreiding van de nieuwe natuurwetenschap in Europa. Zo had het ook invloed op de samenstellers van de beroemde Encyclopédie, waarin delen van haar tekst zijn terug te vinden, en op latere geleerden zoals de filosoof Immanuel Kant. Deze vertaling wil het werk van Mw. De Markiezin van Chastellet onder een Nederlandstalig publiek de bekendheid geven die het verdient.
Inclusion of physical medicine and rehabilitation in the medical curriculum: A step in the right direction
Authors: SINGH NEHA
Published: July 2023

Background

Although physical medicine and rehabilitation (PMR) was first introduced in India in the 1960s, it was not until the 1990s when it was offered as an optional rotation to Indian medical graduates. Lately, with the introduction of a competency-based undergraduate curriculum in 2018, PMR has been included as an essential subject in the medical graduate curriculum, to be implemented from 2019. We aimed to ascertain the importance of incorporating PMR in the medical graduate curriculum while also discussing the awareness about PMR among Indian healthcare professionals.

Methods

We drafted an online questionnaire-based survey and sent that to participants through cloud-based software. Responses were collected over a period of 4 weeks and a descriptive analysis was performed.

Results

The initial hypothesis was that most healthcare professionals would be unaware of the scope of PMR as a medical specialty. The results of this study did not support our hypothesis with 96.8% of the participants being familiar with PMR as a medical specialty. In addition, 85% of the participants reported being introduced to PMR either in their medical school or during their residency training and 92% of the participants appreciated the late integration of PMR within the medical graduate curriculum.

Conclusions

Introduction of medical graduates to PMR would help in bridging the gaps faced by people with disabilities in accessing healthcare facilities. It would also help clinicians from other specialties to collaborate with physiatrists in a more coordinated manner.
An Extrusion Strategy for On-demand SF5Cl Gas Generation from a Commercial Disulfide
Authors: Kordnezhadian Reza , De Bels Tim , Su Kexin , Van Meervelt Luc , Ismalaj Ermal , Demaerel Joachim , De Borggraeve Wim
Published: July 2023

Herein, we report a novel methodology for the ex-situ generation of SF5Cl by employing 4,4′-dipyridyl disulfide as a safe commercial reagent obviating the need for lecture bottles. The method is applicable to certain SF5Cl-involving transformations using a two-chamber reactor. Moreover, easily applying SF5Cl in both polar and non-polar media is rendered feasible while avoiding the use of glovebox techniques. This report also suggests 1H-19F HOESY as a simple and fast stereochemistry indication for chloropentafluorosulfanylated olefins.
Leveraging Bismuth Immiscibility to Create Highly Concave Noble Metal Nanoparticles
Authors: King Melissa , Xu Yuting , Mason Noah , Nagarajan Porvajja , Che Fanglin , Ross Michael
Published: July 2023

The nanoscale integration of metals with differences in structure and electronics, while important for manipulating surface adsorption, does not typically yield structures with well-defined morphologies in colloidal synthesis. To create structures with unusually undercoordinated surfaces, we leverage the immiscibility of face-centered cubic noble metals with rhombohedral Bi to synthesize well-defined nanostructures with controllable concavity. With Au, three distinct morphologies can be achieved: concave tetrahedra, stella octangula (dual tetrahedron), and concave stella octangula. With Pd, we synthesize concave tetrahedra. Structural and compositional analysis shows that only ~ 6 x10 -6 moles of surface Bi are needed to realize these morphologies. Electrocatalytic experiments and simulations reveal that the concave Au architectures are highly active toward alcohol oxidation compared to non-Bi-directed concave nanoparticles and that surface Bi is critical for adsorption. This integration of immiscible elements provides a powerful strategy for creating highly active nanoparticles with precision.
Oxidative cycloaddition reactions of arylboron reagents via a one-pot formal dehydroboration sequence
Authors: Karandikar Shubhendu , Metze Bryan , Roberts Riley , Stuart David
Published: July 2023

Arylboron compounds are widely available and synthetically useful reagents in which the boron group is typically substituted. Herein, we show that the boron group and the ortho-hydrogen atom are substituted in a formal cycloaddition reaction. This transformation is enabled by a one-pot sequence involving diaryliodonium and aryne intermediates. The scope of arylboron reagents and arynophiles is demonstrated and the method is applied to the formal synthesis of an investigational drug candidate.
Fullerene functionalized halogen bonding heteroditopic hosts for ion-pair recognition
Authors: Bąk Krzysztof M. , Marqes Igor , Kuhn Heike , Christensen Kirsten , Félix Vítor , Beer Paul D.
Published: July 2023

Despite their hydrophobic surfaces with localized π holes and rigid well-defined architectures providing a scaffold for preorganizing binding motifs, fullerenes remain unexplored as potential supramolecular host platforms for the recogni-tion of anions. Herein, we present the first example of the rational design, synthesis, and unique recognition properties of novel fullerene-functionalized halogen bonding (XB) heteroditopic ion-pair receptors containing cation and anion binding domains spatially separated by C60. Fullerene spatial separation of the XB donors and the crown ether complexed potassi-um cation resulted in a rare example of an artificial receptor containing two anion binding sites with opposing prefer-ences for hard and soft halides. Importantly, the incorporation of the C60 motif into the heteroditopic receptor structure has a significant effect on halide binding selectivity, which is further amplified upon K+ cation binding. The potassium cation complexed fullerene based receptors exhibit enhanced selectivity for the soft polarizable iodide ion which is as-sisted by the C60 scaffold preorganizing the potent XB-based binding domains, anion-π interactions and the exceptional polarizability of the fullerene moiety, as evidenced from computational DFT calculations. These observations serve to highlight the unique properties of fullerene surfaces for proximal charged guest binding with potential applications in construction of selective molecular sensors and modulating the properties of solar cell devices.
Efficacy of Low-Dose Rituximab in Primary Immune Thrombocytopenia
Authors: Niu Ben , Li Lan
Published: July 2023

Objective: To explore the effect of low-dose rituximab in primary immune thrombocytopenia. Methods: From January 2022 to January 2023, 60 patients with primary immune thrombocytopenia were randomly divided into two groups. The control group was treated with standard doses of rituximab, and the observation group was treated with low doses of rituximab. Rituximab was used for treatment, and the clinical curative effect of the two groups was observed. Results: Before treatment, there was no statistically significant difference in platelet count (PLT), anti-GPⅡb/Ⅲa antibody, and anti-GPⅠb/Ⅸ antibody between the two groups (P > 0.05). After treatment, the PLT of the two groups increased significantly. Antibodies were all decreased, and there was no significant difference between the two groups (P > 0.05). The incidence of adverse reactions in the observation group was 13.33%, and that in the control group was 40.00%. The adverse reactions in the observation group were significantly lower than the control group (P < 0.05). Conclusion: In the clinical treatment of primary immune thrombocytopenia, low-dose rituximab can control the progression of the disease, improve blood routine indicators, and have fewer adverse reactions.
الذكاء الاصطناعي الفائق والأمن الوطني العربي
Authors: El-Adawy Adel
Published: July 2023

تركز هذه الورقة على استكشاف تحديات الأمن الوطني في المنطقة العربية التي تتصل بأنظمة الذكاء الاصطناعي الفائق. ويتميز الذكاء الاصطناعي الفائق وتطبيقاته المختلفة، بأنه يفوق الذكاء البشري، بما يثير العديد من المخاوف المتعلقة بعدم قدرة البشر على السيطرة والتحكم في هذه الأنظمة، علاوة على مخاطر الانقراض البشري، وعدم التوافق مع القيم الإنسانية، لذلك يعتبر الاستعداد لهذه التطورات التكنولوجية أمرًا حاسمًا للأمن الوطني في المنطقة العربية. ولا تزال أنظمة الذكاء الاصطناعي تعتمد في الوقت الراهن على مراقبة البشر، لذلك فإن التطور المتسارع لخوارزميات هذه الأنظمة، يجعلها تتجاوز قدرة البشر على المراقبة، كما أن منظومة الأمن العربية لم تدرك بعد مدى خطورة هذا التهديد، لذلك فإنه من الضروري تبني سياسات استباقية قبل أن يصبح من الصعب احتواء المخاطر والتهديدات. هناك عديد من العقبات التي تحد من أن تحرز بعض الدول العربية مركزًا متقدمًا في مجالات تطور تكنولوجيا الذكاء الاصطناعي الفائق، منها: ضعف البنية التحتية التكنولوجية، وقيود الخصوصية على البيانات، والوصول المحدود إلى الموارد الحاسوبية ولوازم تطوير نماذج الذكاء الاصطناعي الفائق، مما قد يؤدي إلى تبعية تكنولوجية تنعكس سلبًا على الأمن العربي بشكل عام. علاوة على ذلك، تتضمن تكنولوجيا الذكاء الاصطناعي الفائق مخاطر إساءة استخدام البيانات، واضطرابات سوق العمل، والاستعمار التكنولوجي المرتبط بالبيانات، إضافة إلى فرض القيم من قبل الدول الغربية المسيطرة على تكنولوجيا الذكاء الاصطناعي الفائق. كما أنه من المحتمل مع إمكانية ظهور الأسلحة المستقلة وجنود الذكاء الاصطناعي، وعدم اليقين المرتبط بأخلاقيات مثل هذه التكنولوجيا فيما يتصل بالنزاعات والحروب والقتل، أن يؤدي ذلك إلى عدم التوافق بين الذكاء الاصطناعي الفائق والقيم الإنسانية المشتركة، وتفويض أنظمة الذكاء الاصطناعي باتخاذ قرارات متعلقة بالحياة والموت أمرٌ خطيرٌ جداً وقد يؤدي إلى نتائج كارثية. وللتعامل مع هذه التحديات والمخاطر الأمنية، توصي الورقة بضرورة تبني رؤية استثمار الدول العربية في البنية التحتية الرقمية، وتطوير الكفاءات الوطنية في مجال الذكاء الاصطناعي، ووضع الأطر التنظيمية، وضمان التمثيل العادل في التعامل مع البيانات، وبناء آليات التحكم لموائمة القيم، وتعزيز التعاون الدولي
Qadınlarda ürək əməliyyatı sonrası hamiləliyin gedişi, doğuş və doğuşdan sonraki dövr
Authors: A.E. Huseynova
Published: July 2023

Hal-hazırda, ürək cərrahiyyəsinin intensiv inkişafı və müvəffəqiyyəti sayəsində qazanılmış və ya anadangəlmə ürək qüsurlarının cərrahi korreksiyasına məruz qalan hamilə qadınların sayı artmaqdadır. Əksər hallarda cərrahi müalicə qadını təkçəhəyat və iş qabiliyyətinə yox, həm də reproduktiv funksiyanı qaytarır. Son məlumatlar ürək-damar xəstəliklərinin hamiləliklə bağlı ölümlərin 26,5% -ni təşkil etdiyini göstərir [1, 2].Hazırki məqalənin məqsədi ürək əməliyyatı keçirən qadınlarda hamiləlik, doğuş və doğuşdan sonrakı dövrlə bağlı mövcud məlumatların analitik araşdırılmasıdır.
Prediksi Tingkat Kesehatan Lingkungan Masyarakat Dalam Program Sustainable Development Goals Menggunakan Algoritma Naive Bayes
Authors: Zulkipli Zulkipli , Kusrini Kusrini , Sudarmawan Sudarmawan
Published: July 2023

Indications of a decrease in the level of public awareness about protecting the environment have a direct effect on the urgent need for integrated environmental planning and management, so that the impact affects other aspects, such as the physical and socio-economic environment. The fact is that environmental damage is closely related to poverty and economic growth. In maintaining community environmental health and implementing the Sustainable Development Goals Program in East Lombok Regency, West Nusa Tenggara. Hamzanwadi University is working with the East Lombok Regency government to conduct sampling of the community with a total data of 4624 residents in ten sub-districts in the East Lombok Regency area. The purpose of this study is to help predict the level of public environmental health in the East Lombok region, the data will be classified and then processed using the Naïve Bayes algorithm with the multinomial naïve Bayes method. The results of testing the naïve Bayes algorithm after splitting the data five times, the best results were obtained, with the dataset divided by 20% testing data and 80% training data, an prediction value of 93.28% was obtained. The population environment in ten sub-districts in East Lombok Regency was classified as healthy
Improving Financial Literacy Knowledge from An Early Age by Socialization and Training to The Elementary School in Medan City
Authors: Rosalia Vicky , Simatupang Dewi Ratna Sari , Anggia Yola
Published: July 2023

Financial literacy is the ability and the knowledge of individual or communities regarding to all their financial resources from decision making until how to manage it. Therefore, education about financial literacy is very necessary from an early age, especially starting from elementary school student. The problem at the 060888 Public Elementary School in Medan at this time is no financial literacy education, so that the correct introduction and implementation of financial literacy has not been implemented yet. By this community service program, students get a good understanding and knowledge about financial literacy. This program is carried out by several methods, there are financial literacy education, implementation of financial literacy, and provide reading corners by providing financial books for elementary school student as well as monitoring and evaluating.
Working Capital Training and Preparation of Business Cash Projections for Titi Putih Village Community, Lima Puluh Pesisir District, Batubara Regency, North Sumatra
Authors: Muda Iskandar , Maksum Azhar , Azhar Ibnu Austrindanney Sina , Astuti Windi
Published: July 2023

The purpose of this paper is to provide training in the preparation of working capital for residents of Titi Putih village, Batubara Regency, North Sumatra by identifying the allocation of the Production budget, Raw Material Budget, Labor Budget and Sales Budget so that the ideal Working Capital scheme with a certain point of sale will generate cash flow. predictable entry so that people can avoid loans from moneylenders and banking institutions. The method used is a pattern of socialization, training, strengthening governance and monitoring and evaluation. The participants of the activity were residents of Titi Putih village, Batubara. The results show that with the Applied Excel application feature training related to the Preparation of Working Capital by identifying the allocation of the Production budget, Raw Material Budget, Labor Budget and Sales Budget so that the Working Capital scheme will be able to identify certain sales points that will generate cash inflows.
Empowering Community Workhsop to Improve Social Welfare through Innovation in Dolok Merawan
Authors: Fadli  , Paidi
Published: July 2023

Innovation plays an important role in realizing the ninth goal of sustainable development growths (SDGs), which focuses on increasing industrial capacity and industrial inclusiveness. Partners in this community service program are business actors in the welding workshop sector who have been running their business since 2007. Our Partners still unable to manage their finance. The failures in financial management make it difficult for partners to renew existing equipment. This condition causes the work environment to be not conducive. In addition, the lack of marketing activities means that partners have never received orders from outside their region. This community services want to solve these problems by transferring science and technology as well as additional assistance and capital provided to business actors. The involvement of students in this service program will encourage the implementation of their knowledge by carrying out learning activities outside the campus in the business world. This dedication shows a change in the behavior of business actors, especially in the field of occupational health and safety. Partners have started to separate business and household finances. Unfortunately, the optimization of business digitalization is still not optimal.
Metodologiczne i teoretyczne wyzwania badań nad żywotnością etnolingwistyczną grup posługujących się językami kolateralnymi w Polsce
Authors: Dołowy-Rybińska Nicole , Mętrak Maciej
Published: July 2023

This paper presents and discusses the most important methodological challenges of the project “Linguistic diversity in Poland: collateral languages, language-oriented activities, and conceptualization of collective identity” (2021–2026), funded by the National Science Center. These challenges are related to the contestability of the languages studied in the project. It is based on the differentiation between what a “language” is and what a “dialect” is. In the Polish and European acts, linguistic diversity is fully recognized only with regard to those linguistic varieties which are considered independent languages. At the same time, all remaining forms are not taken into consideration. Such subordinate status of different varieties of languages spoken in Poland influences their speakers’ language practices and attitudes. The theory of ethnolinguistic vitality presented in this article is discussed in connection with the situation of five groups that are the objects of this research, namely: Kashubs, Mazurians, Podhalanians, Podlachians, and Silesians."
IMMUNOEXPRESSION OF TWIST IN PATIENTS PRESENTING WITH ODONTOGENIC KERATOCYST
Authors: Ullah Ihsan , Khan Naveed , Rehman Abdur , Naeem Shagufta , Ali Khurshid , Tabbassum Fouzia
Published: July 2023

Objectives: To evaluate the immunohistochemical expression of Twist in patients presenting withOdontogenic keratocyst.Materials and Methods: This study was performed at the department of Pathology, “KhyberMedical University Peshawar” from January 2022 to June 2022.A total of 83 patients meetingthe inclusion criteria were included. All the patients were diagnosed for OKC according to WHOcriteria.Twist immunoexpression of OKC blocks were peroformed according to IHC protocol.SPSS version 22 was used for the analysis of data.Results: Out of eighty three cases of Odontogenic keratocyst, 51 cases were positively stainedfor Twist (61.4%),while 32 cases were negatively stained (38.6%).Amongst the positively stainedcells 17 cases (20.5%) were mild positive,16 cases (19.3%) showed moderate immunopositvityand eighteen cases (21.7%) exhibited strong positivity for Twist.Conclusion: It is concluded that twist immunohistochemiacal analysis shows negative to strongpositive results in odontogenic keratocyst, suggesting its possible neoplastic nature.
RESPONSE TO SYMPTOMATIC TREATMENT IN MITRAL VALVE PROLAPSE, AN EXPERIENCE AT KHYBER PAKHTOONKHWA
Authors: Imran Khan  , Shah Zeb  , Hidayatullah  , Muhammad Ishaq khan  , Muhammad Waleed  , Muhammad Salman
Published: July 2023

Objectives: To determine the subjective response to treatment in mitral valve prolapse patients.Materials and Methods: This was a cross-sectional observational study was conducted in department of Cardiology LRH Peshawar, from 21 November 2019 to 30 April 2020. All consecutive patients having Prolapse of mitral valve fulfi lling the inclusion criteria were studied. Their subjective response to treatment were studied. Statistical Analysis was done with SPSS version 18.0 software. Percentages & Frequency were used for categorical variables like ender, mitral regurgitation and response to treatment. While mean and standard deviation was used for quantitative variables like age were calculated.Results: A total No of 142 patients have documented evidence of echocardiographic mitral valve prolapse were included. They all were and treated with Beta blockers and selective serotonin reuptake inhibitors (SSRI). Mean age were 19.45±7.32 years. Females were 89(62.7%). Out of total study population 128(90%) have palpitation, 111(78%) have chest pain, 102(72%) have dizziness, 93(65%) have Apprehension & Pre-syncope in 85(60%). Of the total, 32(22.53%) patients were also taking ACI/ARB and 42(29.5%) were on benzodiazepine. Their 04 month’s subjective response to treatment was documented. Of all the patients 16 patients have lost to follow up. In the remaining 126 patients, response to medications were excellent in 21(16.67%), good in 29(23.01%), satisfactory/Fair in 41(32.53%). No response to symptoms was documented in 23(18.25%) patients and 12(9.5%) have worsening of symptoms.Conclusion: Symptomatic patients have echocardiographic documented prolapse of Mitral valve fairly respond to SSRIs and beta blockers.
EFFICACY OF INTRAVENOUS IMMUNOGLOBULINS IN RH INCOMPATIBLE NEONATES
Authors: MUHAMMAD IZHAR , HUSNA KHAN  , SANA PERVEZ  , TANVEER AHMAD
Published: July 2023

BACKGROUND

This hemolytic disease of fetus and newborn is a condition in which there is immunologic hemolysis of fetal / neonatal red blood cells.

OBJECTIVE: 

To compare the efficacy of intravenous immunoglobulins in reducing the need for exchange transfusion in Rh incompatible neonates.

MATERIALS AND METHOD: 

This Randomized Controlled Trial was conducted from 1st September 2021 to 31st August 2022 at Department of Pediatric Medicine, Khyber Teaching Hospital, Peshawar. A total of 92 Rh incompatible neonates having bilirubin more than 8mg/dl  were included in the study. Randomization was performed through lottery method. All neonates received conventional intensive phototherapy given by air shield and Ohmeda lamps with  white light  having an intensity of 22 μW/cm/nm plus  blue light of 32 μW/cm/nm. Extra fluids (10 mL per kg) was administered during the phototherapy session. Subjects  in group A  received  conventional intensive phototherapy and IVIG single dose(1 gm/kg). In group B saline was given instead of IVIG. A change in bilirubin of 1mg was considered effective after 4 hours of starting treatment. Data was recorded for efficacy.

RESULTS:

Mean age of  Group A was  15.369± 4.98 days in Group A while 17.782± 3.31 days in Group B. Mean gestational age at birth was 37.608±1.58 weeks in Group A and 38.173±1.71 weeks in Group B. Mean parity was 3.534±0.28 in Group A and 3.387±0.36 in Group B. Mean hospital stay in group A was 3.2±1.5days while 5.7±1.2 days in group B.  In group A, efficacy was seen in 38 (82.6%) patients as compare to 26 (56.5%) patients in group B, resulting in significant reduction of exchange transfusions, duration of phototherapy session and hospital stay (P=0.006).

CONCLUSION: 

          It is concluded that a IVIG administration in patients having significant  hyperbilirubinemia of Rh incompatible neonates caused reduction in requirement for exchange transfusion ,decreased hospital and time duration of phototherapy treatment thus an effective and safe treatment
Análisis de propiedades en la elección social
Authors: Vergara Velez Guilber Enrique , Leal Jahn
Published: July 2023

Realizamos un an´alisis de las propiedades más relevantes en el marco de la teor´ıa de elecci´on social y adicionalmente analizamos nuevas propiedades de racionalidad para las funciones de elecci´on social con perfiles de tamaño variable.
Multiple Year Extension Program Outcomes & Impacts Through Evaluation
Authors: Hachfeld Gary , Bau David , Holcomb Robert , Craig William
Published: July 2023

Dwindling public funding as well as greater competition for grant dollars create a challenge for Extension. For Extension to remain a financially viable organization, educators have to be able to produce substantive, measurable program outcomes and impacts. Evaluative data can inform program development and delivery, and helps administrators report how funding is being allocated and the result of that allocation. Evaluative data can be shared with the public and other stakeholders as a means of garnering organizational support. The objective of this article is to highlight a multi-phase, multiple program year evaluation process resulting in substantive program outcomes and impacts.
Using Audience Response Devices for Extension Programming
Authors: Koff Jason
Published: July 2023

Audience response devices (ARDs), or "clickers," have traditionally been used in the classroom to take attendance, provide testing of current knowledge and knowledge gain, and assist with review of course topics. The ARDs were used at a recent Extension conference, which provided an opportunity to test how well this tool worked. Though not used in this situation, the demographic information collected prior to the presentation could be used to alter the focus in real-time while the assessment data could potentially be useful in providing greater response for evaluation purposes. Participants overwhelmingly liked using the ARDs in an Extension meeting setting.
An ASIC Accelerator for QNN with Variable Precision and Tunable Energy-Efficiency
Authors: Wagle Ankit , Singh Gian , Khatri Sunil , Vrudhula Sarma
Published: July 2023

This paper presents TULIP, a new architecture for a variable precision Quantized Neural Network (QNN) inference. It is designed with the goal of maximizing energy efficiency per classification. TULIP is constructed by arranging a collection of unique processing elements (TULIP-PEs) in a single instruction multiple data (SIMD) fashion. Each TULIP-PE contains binary neurons that are interconnected using multiplexers. Each neuron also has a small dedicated local register connected to it. The binary neurons are implemented as standard cells and used for implementing threshold functions, i.e., an inner-product and thresholding operation on its binary inputs. The neurons can be reconfigured with a single change in the control signals to implement all the standard operations used in a QNN. 

This paper presents novel algorithms for implementing the operations of a QNN on the TULIP-PEs in the form of a schedule of threshold functions. TULIP was implemented as an ASIC in TSMC 40nm- LP technology. A QNN accelerator that employs a conventional MAC-based arithmetic processor was also implemented in the same technology to provide a fair comparison. The results show that TULIP is 30-50X more energy-efficient than an equivalent design, without any penalty in performance, area, or accuracy. Furthermore, TULIP achieves these improvements without using traditional techniques such as voltage scaling or approximate computing. Finally, the paper also demonstrates how the run- time trade-off between accuracy and energy efficiency is done on the TULIP architecture.