bluuebunny/crossref_metadata_2025 huggingface dataset:
An Educational Robotics Approach to Drawing and Studying Central Trochoids at the University Level
Authors: Körei Attila , Szilágyi Szilvia , Vaičiulyté Ingrida
Published: November 2024

Educational robotics has become increasingly popular in STEM education, offering motivating and hands-on learning experiences. The use of robots in science education is widespread, mainly in primary and secondary schools, whereas there is little research in higher mathematics education in this area. This paper explores the potential of educational robotics for teaching plane curves at the university level. Specifically, it investigates the development and implementation of a LEGO Education SPIKE Prime robot designed to draw various central trochoids, including epicycloids and hypocycloids. The robot’s construction and programming are described in detail, emphasising the relationship between the physical movements of the robot and the mathematical equations of the curves it produces. The study also examines the integration of dynamic geometry software, which allows for visualising the curves and verifying the robot’s accuracy. The development process of the drawing LEGO robot followed the V-model methodology. Functional and manual testing of the drawing robot was conducted in a classroom environment with ten students. Based on the feedback from students, the paper concludes that educational robotics can serve as a valuable tool for enhancing both theoretical and practical understanding of mathematical and engineering concepts, offering a more engaging and interactive approach to learning.
False Data Injection Attacks Detection Based on Stacking and MIC-DCXGB
Authors: Li Tong , Xia Tian , Zhang Haoming , Liu Dongyang , Zhao Hai , Liu Zhuolin
Published: November 2024

With the integration of sustainable energy, the power grid has become increasingly information-intensive and complex. To address the issue of power grid cyber-physical systems being unable to operate securely and stably when systems suffer false data injection attacks, a two-stage detection method based on Stacking and Maximum Information Coefficient and Dual-layer Confidence Extreme Gradient Boosting (MIC-DCXGB) is proposed by the paper. Firstly, a Stacking classification model consisting of multiple heterogeneous learners detects anomalies in real-time measurement data samples to determine if false data are present. Secondly, the method incorporates the Maximum Information Coefficient (MIC) for feature selection, which non-linearly measures the correlation between data features and fairly removes redundant features by evaluating the amount of information one feature variable contains about another. This approach effectively tackles the high-dimensional redundancy problem commonly faced in false data injection attack detection. Then, the paper introduces a dual-layer confidence Extreme Gradient Boosting (XGBoost) tree with positive feedback information transmission to classify node states. By combining grid topology learning with label correlation, it selectively uses preceding label information to reduce errors in the predictions learned by subsequent classifiers, achieving precise localization of the attack positions. Finally, extensive simulations validate the effectiveness of the proposed method.
Assessing the Effectiveness of Climate-Smart Irrigation Practices in Improving Household Income Among Smallholder Maize Farmers in Botswana
Authors: Jagadeesh Dhanya , Christian Mzuyanda , Letsoalo Simon
Published: November 2024

The growing impacts of climate change have adversely affected smallholder farmers across the world, leading to low output, decreased incomes, and high levels of food insecurity. As a result, farmers have been advised to find alternative ways of dealing with this phenomenon. The low adoption of climate-smart irrigation technology in Botswana warrants an investigation into the factors and the impact of adoption. This study used a semi-structured questionnaire to collect data from 271 smallholder maize farmers, who were selected through a multi-stage sampling approach. Descriptive statistics, probit regression, and propensity score matching technique (PSM) were employed to analyze the data. The results revealed that the majority of the respondents (55%) were male and 62% of farmers were above 50 years. The majority (62%) of the participants had a farm size of less than 5 ha and were heavily reliant on family labour for farm operations. Despite high (66%) awareness of climate-smart irrigation technology, many (52%) farmers did not adopt smart irrigation in Botswana. Age, gender, and access to credit had a statistical and negative influence on adoption. However, level of education and farming experience had a positive influence on adoption. The result of the propensity score matching model indicated that farmers using climate-smart irrigation techniques experienced positive and significant improvement in crop yield compared to dryland farmers. The study recommends that relevant institutions in Botswana should design a strategy that will be tailored to addressing issues of access to credit, facilitate training and education on advanced irrigation methods, and encourage more young farmers to engage in farming activities.
Exploring the Risks of Green Crowdsourcing in South Africa: The Case of Dilivari
Authors: Okoche John Michael Maxel , Amadi-Echendu Anthea , Mkansi Marcia , Chakuzira Wellington , Masilela Phumlani
Published: November 2024

Green crowdsourcing mobile applications provide an appropriate supply chain coordination mechanism for deliveries, harnessing benefits for people, profits and the environment. Despite the benefits, the risks and challenges associated with green crowdsourcing undermine the social, economic and sustainability benefits of last mile logistics. We undertook an exploration of the risks of using the green crowdsourcing Dilivari mobile application (App) innovation in South Africa. The study used an exploratory research case study research design. The study included 54 respondents with rich, in-depth knowledge, 49 participants for focus group discussions (FGDs) and five key informant interviews. Our study established security, legal, human and connectivity risks associated with this app. We focused on the risks and challenges in the literature including critical emergent risks in a developing country context, compatibility of technology, load shedding, mobile penetration, and data costs. Furthermore, we highlighted the security risks posed by theft, robberies and terrorism.
The Influence of Behavioral and ESG Drivers on Consumer Intentions for Online Fashion Renting: A Pathway Toward Sustainable Consumption in China’s Fashion Industry
Authors: Ahmed Bilal , El-Gohary Hatem , Khan Rukaiza , Gul Muhammad Asif , Hussain Arif , Shah Syed Mohsin Ali
Published: November 2024

As the fashion industry faces increasing scrutiny over its environmental impact, collaborative consumption models such as online fashion renting offer potential solutions for fostering sustainability. This study examines the role of environmental, social, and governance (ESG) factors alongside behavioral drivers in shaping consumer intentions toward online fashion renting in China, a model of collaborative consumption that contributes to sustainability by reducing new product demand and promoting the reuse of fashion items. The data was gathered from 403 Chinese customers using a standardized questionnaire. Structural equation modeling (SEM) was used to examine the given study hypotheses. The current study empirically demonstrates that customers’ attitudes, past sustainable behavior, and subjective norms are significant indicators of consumers’ intentions toward online fashion renting. The results further indicate that relative advantage, compatibility, perceived ownership, psychological risk, green self-identity, and experience value are the key drivers of consumers’ attitudes toward online fashion renting. Additionally, the ESG factors were found to have a significant positive impact on consumer attitudes toward online fashion renting, underscoring their importance in driving sustainable consumption patterns. By integrating behavioral and ESG perspectives, the study contributes to the growing discourse on how sustainable consumption patterns can be encouraged within the fashion industry, offering theoretical and managerial implications for fostering sustainable behavior. Directions for future research are also suggested.
Does Presentation Duration Modulate the Effect of Task on Perceptual Organization?
Authors: Buckley Ned , Makin Alexis D. J.
Published: November 2024

Visual symmetry activates the extrastriate cortex. This symmetry activation generates an Event Related Potential (ERP) named the Sustained Posterior Negativity (SPN). The SPN is larger when participants engage in regularity discrimination tasks than luminance discrimination tasks. Two recent studies suggest that the type of task matters more when the stimulus is presented briefly. We tested this claim with a new sample of 52 participants in a within-subjects design. As predicted, the SPNs were larger in Regularity tasks than Luminance tasks. However, contrary to predictions, the effect of the task was very similar in long and short presentation duration blocks. It remains unclear what factors modulate the task effect. However, presentation duration is not as important as previous results suggest.
Primordial Black Hole Messenger of Dark Universe
Authors: Khlopov Maxim
Published: November 2024

Primordial black holes (PBH), if survive to the present time, can be a fraction, or even the dominant form of dark matter of the Universe. If PBH evaporate before the present time, rare forms of dark matter like superweakly interacting or supermassive particles can be produced in the course of their evaporation. Stable remnants of PBH evaporation can also play the role of dark matter candidates. In the context of the modern standard cosmology, based on inflationary models with baryosynthesis and dark matter, which find their physical grounds beyond the Standard models of elementary particles (BSM), primordial black holes acquire the important role of sensitive probes for BSM models and their parameters. It makes PBHs a profound messenger of physics of Dark Universe.
Persistence of Microcystin in Three Agricultural Ponds in Georgia, USA
Authors: Smith Jaclyn E. , Widmer James A. , Wolny Jennifer L. , Dunn Laurel L. , Stocker Matthew D. , Hill Robert L. , Pisani Oliva , Coffin Alisa W. , Pachepsky Yakov
Published: November 2024

Cyanobacteria and their toxins can have multiple effects on agricultural productivity and water bodies. Cyanotoxins can be transported to nearby crops and fields during irrigation and may pose a risk to animal health through water sources. Spatial and temporal variations in cyanotoxin concentrations have been reported for large freshwater sources such as lakes and reservoirs, but there are fewer studies on smaller agricultural surface water bodies. To determine whether spatiotemporal patterns of the cyanotoxin microcystin occurred in agricultural waters used for crop irrigation and livestock watering, three agricultural ponds on working farms in Georgia, USA, were sampled monthly within a fixed spatial grid over a 17-month period. Microcystin concentrations, which ranged between 0.04 and 743.75 ppb, were determined using microcystin–ADDA ELISA kits. Temporal stability was assessed using mean relative differences between microcystin concentrations at each location and averaged concentrations across ponds on each sampling date. There were locations or zones in all three ponds that were consistently higher or lower than the average daily microcystin concentrations throughout the year, with the highest microcystin concentrations occurring in winter. Additionally, microcystin patterns were strongly correlated with the patterns of chlorophyll, phycocyanin, and turbidity. The results of this work showed that consistent spatiotemporal patterns in cyanotoxins can occur in produce irrigation and livestock watering ponds, and this should be accounted for when developing agricultural water monitoring programs.
Characterizing Host microRNA: Virus Interactions of Orthoavulavirus javaense
Authors: Mears Megan C. , Bakre Abhijeet
Published: November 2024

Post-transcriptional gene regulation mediated by microRNAs (miRNAs) relies on sequence complementarity between the miRNA seed site and the target gene transcript(s). This complementarity can completely inhibit or reduce translation into protein. We hypothesized that viruses employ sequence complementarity/similarity with host miRNAs to inhibit or increase the miRNA-mediated regulation of host gene expression specifically during viral infection(s). In this study, we focus on Orthoavulavirus javaense (OAVJ), the causative of Newcastle disease, a poultry disease with significant economic impact. A computational analysis of OAVJ genomes from low-virulence (lentogenic) versus virulent (velogenic) viruses was carried out to identify viral signature motifs that potentially either mimic or complement host miRNA seed sequences. Data show that OAVJ genomes harbor viral seed mimics (vSMs) or viral seed sponges (vSSs) and can mimic host miRNAs or inhibit their regulation of host genes, disrupting cellular pathways. Our analyses showed that velogens encode a statistically significant higher number of vSMs and a lower number of vSSs relative to lentogens. The number of vSMs or vSSs did not correlate with gene length. The analysis of the secondary structures flanking these vSMs and vSSs showed structural features common to miRNA precursors. The inhibition or upregulation of vSS-miR-27b-5p altered P gene expression in a sequence-dependent manner. These data demonstrate that viral transcripts can interact with host miRNAs to alter the outcomes of infection.
Epidemiologic and Clinicopathological Characterization of Feline Mammary Lesions
Authors: Souza Fernanda R. , Moreira Isabella S. , Dariva Artur A. , Nakagaki Karen Y. R. , Abreu Camila C. , Balabram Débora , Cassali Geovanni D.
Published: November 2024

Most lesions found in the mammary glands of cats are malignant, with aggressive behavior and unfavorable prognosis. Studies on the epidemiologic and clinicopathological characteristics of mammary lesions in cats are scarce. The present study aimed to evaluate those characteristics and to correlate them with survival in cats. Mammary specimens were selected from 418 domestic cats that underwent surgical removal with or without lymphadenectomy. The cats and mammary lesions were evaluated for epidemiologic, clinical, and pathologic characteristics. Cats with malignant neoplasms were older than cats with benign neoplasms and non-neoplastic lesions; 858 lesions were identified, including sporotrichosis, basaloid carcinoma, and benign phyllodes, described for the first time in cats. Tubulopapillary and cribriform carcinomas were the most common malignant tumors found and were very similar in characteristics such as marked anisocytosis/anisokaryosis, high mitotic count (score 3) (p < 0.001), and presence of necrosis (p = 0.005). The association between advanced age and malignancy, as well as the description of new lesions, emphasizes the importance of population studies in cats to understand the behavior of the disease and to draw attention to diagnoses that should be considered in routine care.
Zaręczenie Wzajemne Obojga Narodów. Analiza języka politycznego
Authors: Butterwick Richard
Published: November 2024

Wspólne litewsko-polskie obchody 230. rocznicy Konstytucji 3 maja 1791 roku skłaniają do uważnej lektury Zaręczenia Wzajemnego Obojga Narodów z 20 października 1791 roku pod kątem języka politycznego. Tendencja do scalenia Rzeczypospolitej składającej się z „obojga narodów” – Korony Polskiej i Wielkiego Księstwa Litewskiego – w jeden „naród polski”, widoczna w tekście Ustawy Rządowej, została odwrócona w ustawodawstwie ostatniego roku Sejmu Wielkiego. Trzeba jednak uwzględnić to, że pojęcie „narodu” pozostało płynne, niejednolite i co najmniej dwuszczeblowe.
Projekty wychowania obywatelskiego młodzieży w dokumentach Komisji Edukacji Narodowej, poprzedzających wydanie Ustaw z [1781] 1783 roku
Authors: Kula Ewa
Published: November 2024

Zadanie modernizacji państwa i społeczeństwa uwzględniała w swoich założeniach Komisja Edukacji Narodowej. Dla działaczy państwowych, jakimi byli członkowie Komisji, znaczenie oświaty i wychowania dla interesów państwa było oczywiste. Między innymi Ignacy Jakub Massalski interesował się oświatą ludu, a Adam Kazimierz Czartoryski był komendantem Szkoły Rycerskiej w Warszawie. Pod wpływem zachodnioeuropejskich prądów oświeceniowych, ale także własnych doświadczeń, Komisja postawiła za cel wychowanie dobrego człowieka i obywatela, syna ojczyzny. Tak sformułowane cele, zanim zamieszczone zostały w Ustawach Komisji Edukacji Narodowej dla stanu akademickiego i na szkoły w krajach Rzeczypospolitej przepisane z 1783 r., pojawiały się w dokumentach, opracowanych i ogłoszonych w latach poprzedzających opublikowanie wspomnianych Ustaw.
PAULO FREIRE NA PRÁTICA
Authors: Lima Dubeux Abensur Patricia , Dos Santos Almeida Cláudia , Dantas Souza Karolyne
Published: November 2024

Este artigo apresenta uma experiência transformadora e inovadora: o curso de extensão do programa "Universidade e Participação Social" (PUPS), promovido pelo Núcleo de Estudos, Pesquisas e Extensão de Famílias e Políticas Públicas (NEF). Com uma abordagem inspirada nos princípios pedagógicos de Paulo Freire, o curso foi criado para imergir os participantes na obra e na prática do educador, destacando a importância vital de suas ideias para enfrentar os desafios sociais e educacionais de hoje. Ao incentivar a reflexão crítica sobre temas essenciais como liberdade, democracia e justiça social, a iniciativa não só fortaleceu o compromisso com a transformação social, mas também impulsionou a construção de uma sociedade mais ética, solidária e democrática. Este trabalho evidencia como a educação, quando aliada aos ideais de Freire, se torna uma ferramenta poderosa para a promoção de uma cidadania ativa e engajada, essencial para um futuro mais justo e igualitário.
Continuous flow chromium (VI) adsorption onto peach stone- and acrylonitrile-divinylbenzene copolymer-based activated carbons
Authors:   Department of Chemical Engineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Duranoğlu D. , Küçük I. , Beker Ü.
Published: November 2024

Peach stone-based activated carbon (PS-AC) and acrylonitrile divinyl benzene copolymer-based activated carbon (ANDVB-AC) were evaluated in fixed-bed continuous flow Cr(VI) adsorption studies. The results were compared with those for the commercial activated carbon (CPG-LF). Continuous flow adsorption studies were carried out in a fixed-bed column with various concentrations of a Cr(VI) solution of pH 2. The effect of flow rate on the breakthrough capacity was investigated via breakthrough curves. Although total Cr(VI) adsorption capacities were obtained as 122, 58, and 103 mg/g for PS-AC, ANDVB-AC and CPG-LF, respectively, the breakthrough capacities were determined to be 25.0, 35.2, and 30.0 mg/g. When polymer-based AC was used, 61% of the capacity was effectively utilized while with peach stone-based AC, only 21% of the capacity was effectively utilized at a flow rate of 5 mL/min. This difference was attributed to the shorter contact time of the solution in the column and the slower adsorption kinetics of PS-AC. At a lower flow rate (0.96 mL/min) peach stone-AC can be utilized with higher (47%) efficiency. Both peach stone- and polymer- based activated carbons can be effectively utilized in a fixed column under continuous flow with high Cr(VI) adsorption capacities.
Hexarelin modulates stress effects on ghrelin system activity in growing lambs
Authors: Pierzchała-Koziec Krystyna , Scanes Colina Guy , Gajewska Alina
Published: November 2024

Pierzchała-Koziec K., Scanes C. G., Gajewska A. 2024. Hexarelin modulates stress effects on ghrelin system activity in growing lambs. Folia Biologica (Kraków) 72 : 87-96. Hexarelin is a synthetic ligand for the growth hormone secretagogue receptor 1a (GHSR-1a), also known
as the ghrelin receptor. Ghrelin and hexarelin have been observed to influence the HPA axis by increasing the circulating concentrations of both adrenocorticotropin and adrenal glucocorticoid in rats and humans. The aim of this study was to assess the effects of hexarelin on the ghrelin system
and the growth hormone (GH)–insulin-like growth factor 1 (IGF-1) axis in lambs stressed by an emotional factor – isolation. The isolation stress in three-month-old lambs was accompanied consistently by decreases in the plasma con- centrations of ghrelin, hypothalamic ghrelin concentrations,
in vitro hypothalamic ghrelin release and the ghrelin (GHRL) gene's expression. In addition, the isolation stress induced shifts in plasma concentrations of the insulin-like growth factor 1 (increase) and the in vitro release of the growth hormone (increase). An administration of
hexarelin was followed by a decrease in the plasma concentrations of ghrelin, hypotha- lamic ghrelin concentrations and the in vitro release of ghrelin from the hypothalamic tissue. In contrast, there were increases in the plasma concentrations of IGF-1 and GH release in vitro
from the pituitary tissue following the hexarelin administration. The present study provides proof of the interaction between hexa- relin administration and isolation stress. The evidence put forth supports the capacity of the growth hor- mone secretagogues and exogenous ligand hexarelin as
well as endogenous ghrelin to modulate some of the effects of stress on the growth hormone-insulin-like growth factor 1(GH/IGF-1) axis in growing lambs.
Is selected aquaporin expression in the chicken adrenal gland affected by disturbed sex steroid action?
Authors: Hrabia Anna , Wolak Dominika , Frydrych Karolina , Gumułka Małgorzata , Saito Noboru , Sechman Andrzej
Published: November 2024

Hrabia A., Wolak D., Frydrych K., Gumułka M., S aito N., Sechman A. 2024. Is selected aquaporin expression in the chicken adrenal gland affected by disturbed sex steroid action? Folia Biologica (Kraków) 72: 118-129. In our earlier study, we demonstrated changes in the
aquaporin 4 (AQP4) abundance in the reproductive system of hens following a fasting or tamoxifen (TMX; estrogen receptor modulator) treatment. In the present study, we examine the hypothesis that the expression of selected aquaporins (AQPs) changes in the avian adrenal gland under reduced
circulating sex steroid hormone concentrations or a blockage of estrogen receptors. Accordingly, our aim was to examine the AQP1, AQP2, AQP4, AQP5 and AQP9 mRNA and/or protein expression and immunolocalisation in the adrenal glands of chickens after several days of fasting or TMX treatment.
The hens were fasted or treated with TMX every day, until a pause in egg laying occurred in all the hens. Control hens were fed ad libitum or were treated with a vehicle, respectively. The hens were euthanised on Day 6 or 8 of the experiment, respectively, and the adrenal glands were
collected. Subsequently, the gene and protein expressions of AQPs in the tissues were examined by quantitative real-time PCR and Western blotting, respectively. The fasting, which is accompanied by dimi- nished plasma concentrations of sex steroids, caused a decrease in the relative abundance
of AQP1, AQP2, and AQP9 mRNA transcripts, while the TMX treatment lowered the AQP2 and AQP4 mRNA transcript levels. However, the abundances of AQP proteins were not changed by the fasting and TMX treatment. Immunoreactivity for AQP1, AQP2, and AQP9 protein was localised to the adrenal gland
chromaffin cells and adrenocortical cells; whereas for AQP4 it was localised exclusively to chromaffin cells. In summary, the selected AQPs seem to be important for the regulation of the water/glycerol transport required for the functioning of the hen's adrenal gland cells. An involvement
of ovarian steroids, especially estradiol, in the regulation of the AQP expression is also suggested.
Abordagens de preservação alveolar após a exodontia - revisão bibliográfica
Authors: Tessarolo Giulia Donadello , Gonçalves Vanessa , Langa Weslley Alexsander de Oliveira , Peçanha Marcelo Massaroni , Almeida Luiz Guilherme Ribeiro de
Published: November 2024

A inclusão de biomateriais na regeneração óssea visa mitigar a reabsorção da tábua óssea alveolar pós-exodontia. Enxertos ósseos, com ou sem membranas, apresentam resultados positivos, mas enfrentam desvantagens como tempo prolongado para substituição por osso maduro, morbidade cirúrgica e custos elevados. A preservação alveolar imediata após a remoção dentária promove cicatrização natural e mantém o tamanho do alvéolo até a colocação do implante, reduzindo a reabsorção do processo alveolar e auxiliando na reabilitação dental. A escolha do biomaterial adequado requer avaliação criteriosa dos benefícios e riscos, justificando a necessidade de explorar técnicas de preservação alveolar e uso de biomateriais para aprimorar os resultados clínicos. Objetiva-se apresentar os desafios encontrados para a preservação do alvéolo após remoção de elementos dentários, métodos disponíveis eficazes para minimizar a perda óssea e áreas que necessitam de mais pesquisa para otimizar as práticas de preservação do rebordo alveolar. Esta revisão bibliográfica de cunho qualitativo e caráter exploratório baseia-se em artigos  publicados entre os anos de 2014 a 2024, utilizando bases de dados como PubMed, Cochrane, LILACS, MEDLINE, Scielo e BVS.Os dados foram comparados para identificar vantagens, limitações e implicações clínicas. Desse modo, observa-se que é válido e importante o uso dos biomateriais na regeneração óssea pós-exodontia. O que permite concluir que a preservação alveolar após exodontia é essencial para manter o volume ósseo e garantir o sucesso de reabilitações estéticas e funcionais futuras, sendo necessária uma avaliação criteriosa para cada caso.
Insuficiência cardíaca em idoso: tratamentos e seus impactos na qualidade de vida dos portadores
Authors: Oliveira José Garibaldi Morais , Silva Júlia Dourado , Pasuch Karolina Fernandes , Camargo Vitória Ribeiro , Chrisostomo Ana Clara Gomes , Moreira Paola Amaral Queiroz , Castro Walleska Umbelina Abadia Rabelo de , Silva Pedro Lucas Mesquita e
Published: November 2024

Introdução: Insuficiência cardíaca (IC) é uma doença de grande recorrência e vem causando grande impacto na vida da população, principalmente em idosos. IC é uma alteração estrutural e funcional do coração que é a incapacidade de ejetar ou acomodar sangue dentro dos valores fisiológicos essenciais, e provocam limitação funcional fazendo com que o paciente necessite de uma intervenção terapêutica. As características clínicas mais comuns são: dispneia, edema de membros inferiores, tosse, dor precordial e crepitação pulmonar. Objetivo: análise dos impactos da insuficiência cardíaca (IC) na qualidade de vida da população idosa, assim como a efetividade de tratamentos e seus prognósticos. Metodologia: Trata-se de um estudo de Revisão de Literatura existente até o momento sobre o tema. Para o levantamento dos artigos na literatura, realizou-se uma busca nas seguintes bases de dados: PubMed, Biblioteca Virtual em Saúde (BVS) e Scielo. Foram utilizados, para busca dos artigos, os seguintes descritores e suas combinações na língua portuguesa e inglesa: insuficiência cardíaca AND cardiopatias AND idosos AND tratamento. Discussão: A literatura sobre IC em idosos revela que essa patologia afeta sobremaneira a qualidade de vida dos portadores, causando restrições aos principais hábitos do cotidiano, além de problemas emocionais, físicos e sociais. Conclusão: para promover uma melhora na qualidade de vida e do prognóstico de pacientes portadores de IC, é necessária uma abordagem integrativa, em unidades especializadas com equipes multidisciplinares.
Estimulação do nervo vago: avanços recentes e aplicações clínicas
Authors: Belchior João Victor Lima , Sousa Maria Eduarda Longo , Gurgel Aneybh Oliveira , Bringel Dayane de Oliveira Martins , Figueiredo Luís Felipe Sousa , Araújo Cledson dos Reis , Rodrigues Analice Oliveira , Sakamoto Tayná Fernanda Castelo Branco , Costa Junior Fernando Pinheiro , Bringel Ingryd de Oliveira Martins , Souza Ana Beatriz Matos de , Correia Ana Júlia Silva , Ferro Beatriz Furtado , Carvalho Agesilau Coelho de , Castro Isadora Fontenelle Carneiro de , Viana Ana Helena Jinkings Pavão , Arouche Manoela de Morais
Published: November 2024

A estimulação do nervo vago (VNS) é uma técnica neuromodulatória que usa impulsos elétricos para estimular o décimo nervo craniano, regulando funções involuntárias e sendo aplicada no tratamento de diversas condições neurológicas e psiquiátricas. Este estudo revisa os avanços recentes da VNS, com foco em sua aplicação em epilepsia resistente, reabilitação pós-AVC, transtornos de humor e disfunções cognitivas. A metodologia envolveu uma revisão sistemática qualitativa de estudos publicados entre 2016 e 2024, utilizando descritores específicos nas bases de dados do PubMed, Medline, Cochrane Library e EMBASE. A análise incluiu 7 estudos que abordam tanto a estimulação invasiva quanto a não invasiva. Os resultados mostram que a VNS tem eficácia comprovada na redução de crises epilépticas, especialmente em casos de epilepsia resistente a medicamentos, com efeitos também sobre a neuroplasticidade, facilitando a recuperação motora pós-AVC. Além disso, a VNS demonstrou melhorar sintomas de depressão resistente ao tratamento e ansiedade, com destaque para formas não invasivas, como a estimulação transcutânea. Estudos também indicam o potencial da VNS em suprimir neuroinflamações e melhorar a função cognitiva em pacientes com comprometimento cognitivo vascular. Apesar dos avanços, a personalização dos parâmetros de estimulação e a compreensão completa dos efeitos periféricos ainda requerem mais estudos. A VNS se mostra uma intervenção promissora para uma ampla gama de condições, com potencial crescente para a prática clínica. Nesse sentido, o estudo reforça a relevância da VNS como uma ferramenta terapêutica multimodal, com destaque para seu impacto em condições neurológicas e psiquiátricas.
Avanços na detecção precoce de doenças cardiovasculares através de biomarcadores
Authors: Bittencourt Amicia Jacira Moura Nunes , Penna Ana Clara Della , Ribeiro Bruna Martins , Bianco Débora , Lima Fernanda de Sousa , Deitos Gabriela Eduarda Palauro , Souza Guilherme Batista Teixeira , Oliveira Maria Laura de Paula Angelo , Menasche Nathalie Dockhorn , Lopes Rafael Motta da Costa , Vargas Rafaella Vitória Neres
Published: November 2024

Introdução: As doenças cardiovasculares (DCV) são definidas como um conjunto de afecções que prejudicam a fisiologia cardíaca. Elas abrangem em seu total dez afecções principais, sendo a doença cardiovascular aterosclerótica uma representante substancial da carga global de doenças cardiovasculares. Embora medidas reguladoras de fatores de risco tradicionais de DCV estão bem definidas na literatura, a implementação de biomarcadores na prática clínica capazes de prever e sugerir danos cardíacos existentes estão sendo objetos de estudo. Objetivo: revisar na literatura novos biomarcadores inflamatórios, oxidativos, de disfunção endotelial e cardíaca, averiguando a sua eficácia na previsão de eventos cardiovasculares, de modo a viabilizar intervenções mais precoces e eficazes. Metodologia: revisão integrativa da literatura nas bases de dados PubMed, Scielo e Lilacs, mediante a utilização dos descritores: "Cardiovascular Diseases",  "Biomarkers", "Diagnosis" e "Recent". Foram utilizados artigos publicados entre 2019 a 2024, excluindo periódicos de baixos fatores de impacto e metodologias inconclusivas, portanto após análise foram selecionadas 8 referências. Discussão: A aterosclerose subclínica, a síndrome coronariana aguda, o aneurisma de aorta abdominal, o tromboembolismo venoso, a doença arterial periférica e a insuficiência cardíaca são condições cardiovasculares que demandam atenção à detecção precoce. A aterosclerose, principal causa de morbimortalidade, ainda se apresenta indetectável até eventos agudos, tornando urgente a identificação por meio de novos biomarcadores. Os microRNAs têm demonstrado alta sensibilidade e especificidade, destacando-se no diagnóstico precoce da aterosclerose carotídea e do infarto agudo do miocárdio. A lipoproteína A surge como indicador crítico para a detecção de aneurismas, enquanto o perfil metabólico é promissor na análise do tromboembolismo venoso. A análise da microcirculação retiniana é uma abordagem inovadora para o rastreamento da doença arterial periférica. No contexto da insuficiência cardíaca, biomarcadores como Neopterina, galectina-3 e ST2 têm demonstrado potencial diagnóstico e prognóstico. A integração desses biomarcadores na prática clínica pode aprimorar significativamente a detecção e manejo das doenças cardiovasculares, promovendo melhores desfechos para os pacientes. Conclusão: A incorporação de biomarcadores na prática clínica tem o potencial de transformar o panorama da saúde cardiovascular, proporcionando rastreamento mais eficiente e resposta terapêutica mais adequada, instaurando métodos cada vez menos invasivos que influenciam no curso das doenças, viabilizando o diagnóstico precoce e estratificação de grupos de risco.
Res@LDH: A Novel Nanohybrid Therapeutic for Ischemia–Reperfusion Injury with Dual Reactive Oxygen Species Scavenging Efficiency
Authors: Liu Min , Liu Siyuan , Bai Yafan , Zhang Mingru , Zhang Duo , Sun Ruijin , Wang Guyan , Ma Yulong
Published: November 2024

Ischemic stroke poses a global health challenge, necessitating effective therapeutic interventions given the limited time window for thrombolytic therapy. Here, we present Res@LDH, a novel nanohybrid therapeutic agent boasting a dual reactive oxygen species scavenging efficiency of approximately 90%. Comprising Ge-containing layered double hydroxide nanosheets (Ge-LDH) as a drug nanocarrier and resveratrol as a neuroprotective agent, Res@LDH demonstrates enhanced permeability across the blood–brain barrier, ensuring high biocompatibility and stability. We explored the potential of Res@LDH in mitigating oxidative stress injury induced by middle cerebral artery occlusion and reperfusion in mice, as well as H
2
O
2
-induced cytotoxicity in HT22 cells. Our experiments unveil Res@LDH’s capacity to ameliorate neurological deficits, reduce the infarction volume, mitigate blood–brain barrier disruption, exhibit a robust antioxidant activity, and dampen the release of proinflammatory cytokines. Moreover, Res@LDH treatment markedly attenuates microglial and astrocytic activation. Leveraging a pioneering synthetic approach harnessing Ge-LDH and resveratrol, Res@LDH emerges as a promising strategy for addressing ischemia–reperfusion injury, offering a concise solution to current therapeutic challenges.
Drivers of Ocean Iron Stress Variability in High-Nutrient, Low-Chlorophyll Regions from Ocean Color
Authors: Lin James S. , Letscher Robert T.
Published: November 2024

Determining the seasonal, interannual, and decadal trends of Fe stress in oceanic regions helps quantify the variability in marine nutrient limitations. However, seasonally resolved time-series measurements of dissolved Fe from 3 high-nutrient, low-chlorophyll regions (equatorial Pacific [EQ], subarctic North Pacific [SNP], and Southern Ocean [SO]) are limited to nonexistent. Here, we compared the temporal variability in nonphotochemical quenching satellite-based fluorescence quantum yields (

NPQ-corrected ϕ
sat

), a remote sensing estimate of phytoplankton Fe stress, from 2 decades (January 2003 to December 2022) of monthly ensemble Moderate Resolution Imaging Spectroradiometer–Aqua satellite data with different modes of interannual climate variability. Climatological

NPQ-corrected ϕ
sat

was in the following ascending order: SO (1.51% ± 0.39%, mean ± SD), SNP (2% ± 0.13%), and EQ (2.70% ± 0.16%). The seasonal variability in Fe stress was ±5.6% in the EQ, ±8.51% in the SNP, and ±19.56% in the SO (
n
= 240). EQ Fe stress was correlated with the negative-phase Multivariate El Niño–Southern Oscillation Index Version 2 and positive-phase Southern Oscillation Index, indicating more Fe stress during La Niñas and at colder sea surface temperatures. The SNP region was positively correlated with the North Pacific Gyre Oscillation, indicating more Fe stress at lower sea level heights and upwelling. The SO exhibited seasonally Fe-replete zones; these may be linked to Fe-laden dust and shelf input that are spatially heterogeneous and concentrated around landmasses, whereas sea ice limited data coverage in winter. For both the SNP and SO, monthly chlorophyll and other productivity metrics helped predict future or contemporaneous Fe stress. Fe stress predictability at interannual scales was possible using sea surface temperature and sea level height anomalies, but finer-scale spatial coverage and added observational data are needed to partition climate oscillation effects.
Decoding Phase and Time-Dependent Interferograms of High-Order Harmonics
Authors: Granados Camilo , Hsiao Ching-Ling , Ciappina Marcelo F. , Karki Khadga J.
Published: November 2024

Interferometric measurements of high harmonics induced by multiple laser fields represent a burgeoning field of research, offering prospects for optimized harmonic yield and enabling time- and space-resolved nonlinear spectroscopy. While most investigations have focused on controlling the time delay between pulses, our study introduces a novel approach. By manipulating an additional parameter—the phase difference between the fields—we unveil detailed insights into the physical mechanisms governing the ultrafast processes underlying high harmonic generation. Leveraging high harmonic 2-dimensional interferograms, our method facilitates the streamlined analysis of attosecond electron dynamics in complex molecules and solids, marking an important advancement in this rapidly evolving field.
Marketing digital para la comercialización de "Plastifibra" en Sangolquí
Authors: Martínez Pierina Nayelly Cabo , Quintero Frank Ángel Lemoine
Published: November 2024

El marketing digital ha cobrado mercado en actividades comerciales de emprendimientos en Ecuador impactando directamente en el crecimiento y éxito empresarial. El presente estudio persiguió el objetivo de analizar cómo el marketing digital puede mejorar la comercialización de "Plastifibra" en Sangolquí, optimizando su alcance y efectividad en el mercado local para aumentar su competitividad y visibilidad. Por lo tanto, se llevó a cabo una metodología con un enfoque cuantitativo que combina métodos, descriptivos, analíticos y exploratorios, se aplicó una encuesta a 104 clientes, lo que proporcionó una visión representativa de sus preferencias y percepciones. Para medir la fiabilidad del cuestionario, se utilizó el software estadístico SPSS versión 26, obteniendo un coeficiente de fiabilidad de 0,761, lo que indica una consistencia aceptable en las respuestas. Los resultados de la encuesta revelaron que una gran parte de los encuestados consideraron que los anuncios digitales de "Plastifibra" son poco o nada relevantes, y una alta proporción expresó insatisfacción con la calidad de los productos. Estos hallazgos subrayan la necesidad de que "Plastifibra" ajuste sus estrategias de marketing digital para mejorar la relevancia de sus campañas y la calidad de sus productos. En conclusión, se establece que las estrategias de marketing digital en la alternativa clave para optimizar la comercialización de "Plastifibra", consintiendo a la empresa aumentar su visibilidad y competitividad a nivel de plataforma web.
Explorando el aprendizaje inmersivo en la Educación Superior: una revisión sistemática de la literatura y su aplicación para la enseñanza de la geografía turística
Authors: Alonso Aide Maricel Carrizal , Franco Nancy Testón , Leal Fernando Benítez
Published: November 2024

El avance acelerado de la ciencia y la tecnología ha transformado el ámbito educativo, exigiendo que los métodos de enseñanza se adapten a los desafíos del futuro. La pandemia de 2020-2022 impulsó la innovación pedagógica, introduciendo enfoques como el aula invertida, el aprendizaje móvil, y el aprendizaje inmersivo, que permiten experiencias más dinámicas y atractivas para los estudiantes.
El objetivo de este artículo es analizar el impacto del aprendizaje inmersivo en la educación superior, con énfasis en la enseñanza de la geografía turística. Se realizó una Revisión Sistemática de Literatura, revisando 117 artículos publicados entre 2015 y 2022 en las bases de datos Redalyc, Scopus y Scielo. A partir de criterios de inclusión específicos, se seleccionaron 27 estudios que reportan experiencias del uso de herramientas inmersivas en entornos educativos.
La revisión justifica la necesidad de incorporar estas tecnologías debido a su capacidad para mejorar la interacción y la simulación de realidades complejas, enriqueciendo el proceso de aprendizaje. Los resultados destacan que, aunque los entornos virtuales han mostrado ser herramientas valiosas para la enseñanza, el nivel de desarrollo de estas tecnologías aún no ha alcanzado todo su potencial, y los estudios carecen de consenso sobre sus resultados concretos. Sin embargo, se identifican áreas clave de oportunidad que podrían impulsar su aplicación efectiva en la educación superior.
Hydrocarbonization of the pigeon pea husk as an alternative to increase the biosorption of the industrial dye yellow tartrazine from aqueous solutions
Authors: Bertolani Ana Gabrielly , Silva Caio Henrique da , Andrade João Gabriel da Silva , Scaliante Mara Heloisa Neves Olsen , Rosa Silvia Luciana Fávaro , Batistela Vagner Roberto , Carvalho Fernando Rodrigues de
Published: November 2024

Tartrazine Yellow is a synthetic dye that is part of industrial effluents and can harm the environment when disposed of incorrectly. Biosorbents are alternatives to reduce the cost of the adsorption technique and add value to agricultural wastes. This work reports an investigation regarding the hydrocarbonization process effect on the adsorption capacity of Pigeon Pea Husk, for the removal of the dye from aqueous solutions. The adsorbents were treated chemically and were characterized. The kinetics and adsorption isotherms were investigated and the results showed that the pseudo second-order and Langmuir were the best models, respectively. The hydrocarbonization process increase the adsorption of the adsorbent from 1.54 mg g-1 to 3.60 mg g-1. The increase was even greater in the basic medium, reaching the highest adsorption capacity of 4.78 mg g-1. The hydrocarbonization process was demonstrated to be a sustainable and feasible path to increase the adsorption capacity.
INOVAÇÕES NA CORREÇÃO DE MANIFESTAÇÕES PATOLÓGICAS EM EDIFÍCIOS: REVISÃO DE LITERATURA.
Authors: ALVES BARROS GETSEMANE , Aviz Palma e Silva Arthur
Published: November 2024

Buildings must provide the user with physical and visual comfort, in addition to structural safety. However, it is common for pathological manifestations to appear at any stage of construction or use of the building. In order to indicate appropriate therapy, it is necessary to know the origin of the problem whose study procedures are part of the branch of Building Pathology. The main instructional methods that professionals involved in the area validate are specified in the IBAPE National Building Inspection Standard, which establishes criteria and procedures related to building inspection. In the search to solve such problems, innovative measures found in Brazil. In this sense, this study aimed to present innovative measures aimed at correcting pathological manifestations in buildings. In the methodology used, it is an integrative review of the literature, based on scientific articles, periodicals and current legislation on the respective topic. Data collection was carried out through databases such as Scielo, Google Scholar, among others, from 2019 to 2023. In the results, it was evident that the correction of pathological manifestations in buildings is a vital area in civil engineering and in construction, focusing on the identification, analysis and resolution of structural and functional problems that arise over time. Innovation in this field can significantly improve the durability, safety and functionality of buildings..
Paradigmas y métodos de la investigación científica
Authors: Sucari Wilson , Sucari Henry , Calsin Mabel , Mamani Jose , Choque César , Gil Irene
Published: November 2024

En el contexto investigativo actual resulta relevante conocer los principales paradigmas y métodos que guían la investigación científica en diversas disciplinas. Esta obra ofrece una visión crítica y detallada de los paradigmas que dan origen a los enfoques cualitativos, cuantitativos y mixtos, explorando las características distintivas de cada uno y sus aplicaciones en la práctica investigativa. A lo largo del libro, se destacan las bases epistemológicas que sustentan estos enfoques, mostrando cómo los investigadores seleccionan el paradigma más adecuado según la naturaleza de sus preguntas de investigación y los objetivos que persiguen. Además, se exploran las corrientes y representantes de estos paradigmas con sus diferencias y explicación de su propia naturaleza. El libro se convierte en una guía valiosa para académicos, estudiantes y profesionales interesados en comprender y aplicar metodologías de investigación de manera rigurosa y fundamentada.
A Cognitive Explanation of the Asymmetry in Event/Propositional Interpretation of Finite/Non-finite Adnominal Clauses
Authors: Kim Taein , Park Hyoungjin
Published: November 2024

This study aims to explain the phenomenon where non-finite clauses, which originally denote events, can sometimes represent propositions, while, asymmetrically, finite clauses that express propositions cannot denote events in any context. To explore this, the methodology of “ultimate explanation” from evolutionary psychology is introduced. While this phenomenon could be explained through type coercion or polysemy, such explanations are not considered ultimate. This paper adopts an explanation based on cognitive systems as the ultimate explanation. Event memory can become semantic memory, but semantic memory cannot become event memory. This asymmetry in cognitive systems is directly reflected in language, leading to the asymmetrical interpretation of non-finite and finite clauses.
The Information Structure of Contrastiveness
Authors: Huh Chul-gu
Published: November 2024

Contrastive focus and contrastive topic share the characteristic of being associated with the particle ‘-은/는’ in Korean. While contrastive focus can refer to elements marked by case particles such as ‘-이/가,’ it is also defined in some cases as focus marked by the particle ‘-은/는.’ Although ‘-은/는’ is sometimes viewed as indicating topics rather than focus, in contexts where it introduces new information, it can function as contrastive focus. Unlike case particles such as ‘-이/가,’ which do not necessarily imply a consideration of alternative items within a paradigmatic relationship, the particle ‘-은/는’ as contrastive focus operates within a series of comparable or contrasting elements, due to its role as an auxiliary particle. Therefore, the distinction between these two types of focus cannot be fully explained through notions such as exhaustivity or prominence; rather, it should be understood based on the inherent properties of these particles. Similarly, contrastive topics can be consistently understood within the same framework as contrastive focus, given the particle ‘-은/는’ shares these functions. Both contrastive topics and contrastive focus can co-occur, as seen in responses such as ‘철수는 왔어요(Cheolsu has come),’ in response to the question, ‘누가 왔니(Who came)?’ Here, ‘Cheolsu’ is interpreted as a topic, while simultaneously functioning as new information, thus embodying both the characteristics of a topic and a focus.