bluuebunny/crossref_metadata_2025 huggingface dataset:
On the Mastery of Elementary Geometric Concepts
Authors: Talyzina Nina F.
Published: October 2023

We publish here the report by N.F. Talyzina to a Conference on Psychology in 1955 and released two years later in the proceedings of that conference (N.F. Talyzina [1957]. In B.G. Anan′yeva et al. [Eds.], Materialy soveshchaniia po psikhologii. July 1–6, 1955. Moscow: Publishing House of the Academy of Pedagogical Sciences of the RSFSR.) This report is of particular interest, since it describes some of the first formative experiments based on the theory of planned stage-by-stage formation of mental actions; the text does not yet discuss the formation of actions, but only the application of the attributes of concepts to solving problems. The text presents the results of a study of the formation of elementary geometric concepts according to the theory of planned stage-by-stage formation of mental actions and concepts. Twenty-two subjects from grades 6–9 formed geometric concepts such as “line,” “angle,” “angle bisector,” “perpendicular,” “adjacent angles,” and “supplementary angles.” These attributes were formed in the process of their application to solving different types of problems. Observational and then formative (training) experiments were performed individually. The article contains excerpts from the subjects’ protocols as they solved the problems. It was shown that stage-by-stage development (identifying attributes from a definition, saying them aloud, and then applying them to solving problems) leads to mastery not only of the geometric concepts themselves, but also of the method of action with definitions in general, allowing students to transfer the method they have learned to concepts from another field of knowledge.
Cross-Language Validation and the Factor Structure of the Social-Emotional Competence Questionnaire for Pakistani Adolescents
Authors: Jabeen Tahira , Maqsood Aneela
Published: October 2023

Background. For the last few years, in the field of school education, social-emotional competencies have been gaining in importance because they result in positive attitudes and adaptation to school (Mella et al., 2021). Objective. The current study was designed to conduct Urdu translation, cross-language validation, and confirmatory factor analysis of the Social-Emotional Competence Questionnaire (SECQ) for Pakistani adolescents. Design. Urdu translation was done using the standard back-translation method. The data for the main study was collected using a non-random sampling method for 910 adolescents who were between 10 to 17 years old. Results. The findings of the pilot study (n = 64) show that the Social-Emotional Competence Questionnaire is a reliable questionnaire, as Cronbach’s alpha reliabilities of both versions (English and Urdu) were acceptable (Version 1 α = 0.77; Version 2 α = 0.77). After 15 days, the Pearson product-moment correlation was checked to meet the objective of cross-language validation, which resulted in a high correlation between the two forms (r = 0.88). The riginal author of the questionnaire had proposed a factor structure consisting of five factors, namely: self-awareness, social awareness, self-management, relationship management, and responsible decision-making. Results of the confirmatory factor analysis (CFA) in the present study also confirmed and supported the five-factor structure in comparison to other models for the Urdu version. Conclusion. The Social-Emotional Competence Questionnaire is a reliable and culturally-validated tool for adolescents attending school, which can be used in future research for measuring social-emotional competencies.
An Independent Evaluation of the Psychometric Properties of the Russian Version of the Pediatric Daytime Sleepiness Scale (PDSS)
Authors: Zakharov Ilya M. , Ismatullina Victoria I. , Kolyasnikov Pavel V. , Marakshina Julia A. , Malykh Artem S. , Tabueva Anna O. , Adamovich Timofey V. , Lobaskova Marina M. , Malykh Sergey B.
Published: October 2023

Background. The quality of sleep significantly impacts children’s day-to-day performance, with at least 20% reporting issues with sleepiness. Valid tools for assessing the quality of sleep are needed. Objective. In this study, we assessed the psychometric properties of the Russian version of the Pediatric Daytime Sleepiness Scale (PDSS). The initial adaptation of the PDSS was conducted on a sample from the Arctic regions of Russia. This location may have influenced the scale's generalizability due to variations in natural daylight across different areas of the country. Design. To rectify this, we gathered a comprehensive, geographically diverse sample from Russia. This combined dataset comprised 3772 participants between 10 to 18 years of age, from nine different regions of Russia. Results. We confirmed the unifactorial structure of the PDSS, which showed no regional effects. The psychometric analysis indicated that one item from the 8-item PDSS could be removed, thereby improving the scale's model fit. We also observed gender and age impacts on sleep quality: boys reported fewer sleep-related issues than girls, and younger children reported fewer problems than older children. Conclusion. This study validates the usefulness and reliability of the Russian version of the PDSS, thereby enhancing its general applicability. Furthermore, we replicated previously reported age and sex effects on the sleep quality of school-aged children.
Local scale population risk determines the adaptive responses of larval salamanders to predator kairomones
Authors: Cannon Christopher L. , Davenport Jon M.
Published: October 2023

Organisms can exhibit plasticity in phenotypic responses to environmental stimuli but the response can vary based on the evolutionary history of a population. Numerous studies have found that prey will express adaptive responses when subjected to various predators in experimental settings. For species with a large distribution, such as Ambystoma maculatum (spotted salamander), it is not surprising that phenotypic variance can be high across their range. This variance has been hypothesized to be because of different predator regimes of populations. While A. maculatum preferentially oviposit eggs in low-risk ponds (temporary fishless) to decrease egg and larval mortality, Missouri populations still use high-risk ponds (permanent with fish) for reproduction. Using a series of experiments, we investigated how A. maculatum population risk influenced adaptive responses to both native and novel predator kairomones. For natural predators, we used larval A. opacum (marbled salamanders) and Lepomis macrochirus (bluegill) and for novel predators we used Siren intermedia (lesser siren). We found that larval salamanders generally responded with no differences in morphological traits to all three predators. However, head width was larger for low-risk populations. One hypothesized benefit of larger heads (increased foraging efficiency) was not fully supported. All larval salamanders also increased refuge use with predators but this decreased over time. Our results suggest that predation risk of a population may influence the degree of phenotypic expression in response to larval predators. Overall, local adaptation may dictate the ability of prey to respond to environmental conditions within a life stage.
A new intertidal species of the thorid shrimp genus Heptacarpus Holmes, 1900 (Decapoda: Caridea) from Japan
Authors: KOMAI TOMOYUKI
Published: October 2023

A new species of the thorid shrimp genus Heptacarpus Holmes, 1900, H. sadoi, is described and illustrated on the basis of six specimens from the southeastern coast of the Boso Peninsula, central Japan. All the specimens were collected from intertidal tide pools at low tide. Heptacarpus sadoi n. sp. belongs to the species group with epipods on the pereopods 1–3 and appears morphologically close to H. jordani (Rathbun, 1902) known from Japan and Korea. The new species is readily differentiated from H. jordani by the short rostrum with fewer dorsal teeth and the possession of only one spine on the distal margin of the basal article of the antennular peduncle. Genetic comparison using two mitochondrial markers (COI and 16S rRNA genes) also supports that the new taxon is distinct from H. jordani.
First report of Sharqencyrtus Hayat and Kazmi (Hymenoptera, Encyrtidae) from China, with the description of a new species
Authors: WANG HAIYANG , ZHANG CHENGHUI , CHI ZHIHAO , XUE HAO , ZU GUOHAO
Published: October 2023

The genus Sharqencyrtus Hayat and Kazmi is recorded for the first time from China (Zhejiang province, Yuyao city), and Sharqencyrtus yaobangi Zu, sp. nov., is described as new to science.
Health Care Stereotype Threat and Sexual and Gender Minority Well-Being
Authors: Saunders R. Kyle , Carr Dawn C. , Burdette Amy M.
Published: October 2023

Sexual and gender minorities (SGMs) have experienced progressive change over the last 50 years. However, this group still reports worse health and health care experiences. An innovative survey instrument that applies stereotype threat to the health care setting, health care stereotype threat (HCST), offers a new avenue to examine these disparities. We harmonized two national probability data sets of SGMs—Generations and TransPop—capturing 503 gay men, 297 lesbians, 467 bisexuals, and 221 trans people. Using these data, we, first, explored how HCST’s association with self-rated health and psychological distress changed while considering more established constructs: discrimination and stigma. Second, we examined how HCST’s association varied across SGM groups. Results suggest that HCST is a unique predictor net of the associations with discrimination and stigma. Furthermore, results highlight the more consequential associations for trans people on well-being compared to gay men. We discuss implications of these findings for future research and potential interventions.
Modelling the factors that determine online news-sharing behaviour of social media users: The role of perceived message and online environmental characteristics
Authors: Na Risu , Wang Yaqin , Na Buqi , Ning Yucheng , Destiny Apuke Oberiri
Published: October 2023

This study modelled the online environment characteristics and message characteristics that predict news sharing among social media users. This study’s data were obtained from a cross-sectional national survey conducted in Nigeria. Qualtrics was used to recruit data from 1320 participants in Nigeria. The participants were recruited via a stratified quota sampling which reflected the country’s census statistics for gender and age. We found the message characteristics to predict news-sharing behaviour among social media users in Nigeria. By implication, the characteristics of a message encountered online influence the news-sharing behaviour of social media users. We also found that the online environment characteristics predict news-sharing behaviour, which implies that the external factor, that is, the relationship a user has with his network members, predicts sharing behaviour. Some theoretical and practical implications were provided to conclude the study.
Rethinking “transfer” in the transgenerational transmission of trauma: A qualitative study of the 1984 anti-Sikh violence
Authors: Khanna Anuja , Priya Kumar Ravi
Published: October 2023

Traumatic events, in their aftermath, often induce feelings of injustice or exclusion due to the hierarchies of survivor/non-survivor, religion, race, gender, and so forth, as well as the apathy of governance. However, the transfer of trauma and healing from survivors to their next generation is conceptualized around the past traumatic event and post-traumatic stress disorder. A constructivist grounded theory analysis of the voices of parent survivors and their next generation associated with the 1984 anti-Sikh violence in India is utilized to explore a potential bidirectional transfer of social suffering and healing within the parent–child dyad. The categories suggesting a bidirectional transfer of social suffering are (a) “child inundated,” due to the inadequacy of resources or support, and (b) “parent’s remorse” over being incapacitated and unable to care. The findings do not clearly indicate parent-to-child transfer of healing, yet there are indications of parents’ healing being contributed to by children’s positive and uplifting experiences in the category “parent’s satisfaction through child’s growth and happiness.”
Advancing psychiatry trainee wellbeing and safety: Building on RANZCP Position Statement 48
Authors: Weightman Michael James , Amos Andrew , Miller Edward
Published: October 2023

Objective

The RANZCP recently released Position Statement 48 on the ‘safety and wellbeing of psychiatrists and those in psychiatry training’. This article will examine the five key domains highlighted by this statement and provide suggestions on how this guidance might relate to trainees. The domains covered are (i) safe workplaces free from discrimination, bullying, harassment, and violence; (ii) positive team cultures; (iii) positive professional peer relationships; (iv) supportive supervision and mentorship; and (v) work–life balance.

Conclusions

In the context of the significant and complex demands of psychiatry training, Position Statement 48 helps to provide a framework for trainees and the people and systems that support them to understand, anticipate, and successfully manage the potential risks to trainee wellbeing and safety.
Effect of pedagogic intervention in enhancing speech fluency by EFL students: A longitudinal study
Authors: Yenkimaleki Mahmood , van Heuven Vincent J.
Published: October 2023

The main goal of many students of English as a foreign language (EFL) is to be fluent in the target language, i.e. to be capable to transfer their thoughts smoothly and easily in different contexts. The present study examines the effect of pedagogic intervention on enhancing speech fluency in EFL using a pretest – immediate posttest – delayed posttest design. Two groups of 32 EFL students at a University in Iran took part in the study, receiving the same amount of instruction (18 hours over 18 weeks). The Control group listened to / viewed authentic audio recordings and movies in English, discussed their contents, and completed a variety of speaking skills tasks but received no fluency training. The Experimental group spent part of the time on fluency strategy training, encouraging the memorization, repetition, and retelling of the audio and video materials. Systematic interviews were run to assess the EFL learners’ speech fluency. The findings revealed that the fluency training significantly enhanced the EFL students’ speech fluency. The findings also show that students’ second language speech fluency development can be partly predicted by the fluency in their first language. These results have pedagogical implications for practitioners in EFL settings, material designers, and EFL instructors.
PD-1/PD-L1 Interaction Upregulates YAP1 Expression in HepG2 Cells Through MAPK/ERK Pathway
Authors: Li Shenghao , Dai Muwei , Wang Fang , Hao Liyuan , Feng Caixia , Jia Yansheng , Li Yaoqi , Kang Xichun , Hu Xiaoyu , Yan Huimin
Published: October 2023

Background

Antibodies, which target programmed cell death protein-1 (PD-1) or its ligand programmed death ligand-1 (PD-L1), can rescue T cells from an exhausted state and resume their immune response to cancer cells. Clinically, the purpose of blocking the PD-1/PD-L1 signaling pathway is to induce immune cells to play an anti-tumor role. However, the effect of intertumor PD-1/PD-L1 signal blocking on tumor cells remains unclear.

Methods

HepG2 cells were treated with DHA, IFN-γ, BSA, DDP, PD-1-Fc (1 μg/ml), IgG-Fc, nivolumab, or human IgG for 24 h, respectively. GEPIA, cBioPortal, and TIMER databases were used to analyze the correlation between YAP1, PD-1, and PD-L1 and ERK, ERK-5, JNK, and p38. Western blot was used to detect the expression of YAP1 and p-ERK.

Results

GEPIA, cBioPortal, and TIMER databases analysis showed that YAP1 was positively correlated with ERK. After HepG2 cells were treated with PD98059 (ERK inhibitor), the expression of YAP1 was decreased. In this study, we investigated the inhibitory effect of PD98059 on PD-1/PD-L1 signaling. Our study found that PD-1-Fc (PD-1 fusion protein) promoted the expression of p-ERK/ERK and YAP1 in HepG2 cells. In contrast, nivolumab (PD-1 blocking antibody) reduced the expression of p-ERK/ERK and YAP1 in IFN-γ-pretreated HepG2 cells. In addition, the application of DHA also inhibited the expression of p-ERK/ERK to inhibit YAP1. Furthermore, treatment of HepG2 cells with DHA alone or DHA combined with cisplatin (DDP) both inhibited the expression of p-ERK/ERK and YAP1.

Conclusions

These results suggested that PD-1/PD-L1 interactions between tumor cells could promote the expression of ERK or YAP1 within tumors. Moreover, the conduction of PD-1/PD-L1 could be reversed using ERK inhibitors.
The nonessential amino acid cysteine is required to prevent ferroptosis in acute myeloid leukemia
Authors: Cunningham Alan , Oudejans Lieve L. , Geugien Marjan , Pereira-Martins Diego Antonio , Wierenga Albertus T. J. , Erdem Ayşegül , Sternadt Dominique , Huls Gerwin , Schuringa Jan Jacob
Published: October 2023

Cysteine is a nonessential amino acid required for protein synthesis, the generation of the antioxidant glutathione, and for synthesizing the nonproteinogenic amino acid taurine. Here, we highlight the broad sensitivity of leukemic stem and progenitor cells to cysteine depletion. By CRISPR/CRISPR-associated protein 9–mediated knockout of cystathionine-γ-lyase, the cystathionine-to-cysteine converting enzyme, and by metabolite supplementation studies upstream of cysteine, we functionally prove that cysteine is not synthesized from methionine in acute myeloid leukemia (AML) cells. Therefore, although perhaps nutritionally nonessential, cysteine must be imported for survival of these specific cell types. Depletion of cyst(e)ine increased reactive oxygen species (ROS) levels, and cell death was induced predominantly as a consequence of glutathione deprivation. nicotinamide adenine dinucleotide phosphate hydrogen oxidase inhibition strongly rescued viability after cysteine depletion, highlighting this as an important source of ROS in AML. ROS-induced cell death was mediated via ferroptosis, and inhibition of glutathione peroxidase 4 (GPX4), which functions in reducing lipid peroxides, was also highly toxic. We therefore propose that GPX4 is likely key in mediating the antioxidant activity of glutathione. In line, inhibition of the ROS scavenger thioredoxin reductase with auranofin also impaired cell viability, whereby we find that oxidative phosphorylation–driven AML subtypes, in particular, are highly dependent on thioredoxin-mediated protection against ferroptosis. Although inhibition of the cystine-glutamine antiporter by sulfasalazine was ineffective as a monotherapy, its combination with L-buthionine-sulfoximine (BSO) further improved AML ferroptosis induction. We propose the combination of either sulfasalazine or antioxidant machinery inhibitors along with ROS inducers such as BSO or chemotherapy for further preclinical testing.
FFT-Based Numerical Method for Nonlinear Elastic Contact
Authors: Guo Fei , Wu Fan , Li Xinyong , Huang Yijie , Wang Zhuo
Published: October 2023

In theoretical research pertaining to sealing, a contact model must be used to obtain the leakage channel. However, for elastoplastic contact, current numerical methods require a long calculation time. Hyperelastic contact is typically simplified to a linear elastic contact problem, which must be improved in terms of calculation accuracy. Based on the fast Fourier transform, a numerical method suitable for elastoplastic and hyperelastic frictionless contact that can be used for solving two-dimensional and three-dimensional (3D) contact problems is proposed herein. The nonlinear elastic contact problem is converted into a linear elastic contact problem considering residual deformation (or the equivalent residual deformation). Results from numerical simulations for elastic, elastoplastic, and hyperelastic contact between a hemisphere and a rigid plane are compared with those obtained using the finite element method to verify the accuracy of the numerical method. Compared with the existing elastoplastic contact numerical methods, the proposed method achieves a higher calculation efficiency while ensuring a certain calculation accuracy (i.e., the pressure error does not exceed 15%, whereas the calculation time does not exceed 10 min in a 64 × 64 grid). For hyperelastic contact, the proposed method reduces the dependence of the approximation result on the load, as in a linear elastic approximation. Finally, using the sealing application as an example, the contact and leakage rates between complicated 3D rough surfaces are calculated. Despite a certain error, the simplified numerical method yields a better approximation result than the linear elastic contact approximation. Additionally, the result can be used as fast solutions in engineering applications.
A case report of Cobb’s collar with posterior urethral valves: a rare entity
Authors: Hameed Farooq , Anwaar Adeel
Published: October 2023

Background

Posterior urethral valve (PUV) is a congenital disorder typically presenting in the neonatal period and is associated with the obstruction of the urinary tract. Cobb’s collar is congenital narrowing of bulbar urethra in infants. It can lead to significant morbidity, which may include irreversible renal failure if left untreated.

Case presentation

A 21-month-old child presented with acute retention of urine and distended lower abdomen. His baseline tests were normal. Ultrasound KUB showed grossly enlarged bladder with almost 1100-ml residual urine. Foley’s catheterization attempted but failed. Urgent cystoscopy was planned where congenital anterior urethral stricture with posterior urethral valves was seen. DVIU done for urethral stricture followed by fulguration of posterior urethral valves. The patient was discharged from hospital the next day.

Conclusion

A congenital narrowing of the bulbar urethra is uncommon. Though it is rare, it can occur concomitantly with PUV. If this double pathology is missed can result in serious consequences. Children with recurrent urinary tract infections should be ruled out for anterior urethral strictures.
Endoscopic iatrogenic esophageal perforation and management: a retrospective outcome analysis in the modern era
Authors: Montminy Eric M. , Jones Blake , Heller J. Christie , Attwell Augustin
Published: October 2023

Introduction

Iatrogenic esophageal perforation (IEP) is a severe adverse event (AE) of upper endoscopy procedures (UEPs) associated with morbidity. Management has shifted from surgery to endotherapy with clip closure (CC), self-expanding metal stent (SEMS), and vacuum therapy (VT). Limited analyses measure outcomes during contemporary interventional endoscopy periods.

Methods

IEPs associated with EGD, upper EUS, small bowel enteroscopy (SBE), and ERCP at a 3-hospital academic center from January 2011 to December 2023 were identified retrospectively from a centralized AE database. Additional information was obtained from medical records. Statistical analysis was performed using Microsoft Excel and STATA.

Results

Thirty-two IEPs from 26 EGDs, 4 EUS, 1 SBE, and 1 ERCP were identified. IEPs occurred mostly after dilation (bougie N = 7; balloon, N = 5) or foreign body removal (N = 6). Most IEPs occurred in the lower esophagus (N = 10) or gastroesophageal junction (N = 8). Diagnosis was made at a median 2 h after the injury by endoscopy (N = 14), CT scan (N = 12), esophagram (N = 5), or x-ray (N = 1). Initial treatment included conservative therapy alone (N = 7), CC (N = 3), SEMS (N = 14), SEMS plus CC (N = 3), or surgery (N = 3). Eleven patients required additional treatment including repeat SEMS or adjustment (N = 4) or VT (N = 1). No surgical interventions were required after 2013. The median hospital stay was 3 days. Disposition included discharge to home (N = 25), long-term care facility (N = 2), 4 deaths (12.5% of IEPs), and 1 unknown.

Conclusions

IEPs are rare and occur throughout the esophagus after any UEP. The majority are recognized immediately and managed with endotherapy, or rarely, surgery today. These characteristics likely explain the low mortality in this study.
Development and validation of a model for early diagnosis of biliary atresia
Authors: Gong Zongrong , Lin Lin , Lu Gen , Wan Chaomin
Published: October 2023

Background and aims

Early diagnosis of biliary atresia (BA), particularly distinguishing it from other causes of neonatal cholestasis (NC), is challenging. This study aimed to design and validate a predictive model for BA by using the data available at the initial presentation.

Methods

Infants presenting with NC were retrospectively identified from tertiary referral hospitals and constituted the model design cohort (n = 148); others were enrolled in a prospective observational study and constituted the validation cohort (n = 21). Clinical, laboratory, and abdominal ultrasonographic features associated with BA were assessed. A prediction model was developed using logistic regression and decision tree (DT) analyses.

Results

Three predictors, namely, gamma glutamyl transpeptidase (γGT) level, triangular cord sign (TC sign), and gallbladder abnormalities, were identified as factors for diagnosing BA in multivariate logistic regression, which was used to develop the DT model. The area under the receiver operating characteristic (ROC) curve (AUC) value for the model was 0.905, which was greater than those for γGT level, TC sign, or gallbladder abnormalities alone in the prediction of BA.

Conclusion

A simple prediction model combining liver function and abdominal ultrasonography findings can provide a moderate and early estimate of the risk of BA in patients with NC.
My virtual home: needs of patients in palliative cancer care and content effects of individualized virtual reality – a mixed methods study protocol
Authors: Gerlach Christina , Greinacher Anja , Alt-Epping Bernd , Wrzus Cornelia
Published: October 2023

Background

The desire to be at home is one of the most important needs of patients with advanced, incurable cancers. However, palliative cancer patients may require inpatient hospital care for medical reasons. Virtual reality (VR) could provide an approximation to the individuals’ home environment.

Methods

The project consists of 3 parts. All parts are supported by the patient advisory board. In the 1st part of the project, we interview patients, relatives, and the patient advisory board about their wishes and concerns regarding the project. In the 2nd part of the project, patients are offered to view 360° VR videos of their choice (their home, relatives, others if applicable). Effects and side-effects of the intervention are assessed with validated instruments (MIDOS, MDBF, SSQ, SPES). Diagnosis, treatment adherence, medication, and vegetative functionality is determined from the medical records of the patients. In the 3rd part of the project, the results of the study will be discussed with patients, relatives, health care professionals and the patient advisory board regarding implementation.

Discussion

This study is the first to investigate whether individualized VR videos have additional benefits over generic VR nature videos on symptom relief, well-being, treatment satisfaction, and adherence in patients with palliative cancer care. A strength of the study is that we can incorporate the results of each part of the project into the subsequent project parts. However, the generalizability might be limited as this is a single-centred study.

Trial registration

Registered at German Clinical Trials Register (Deutsches Register Klinischer Studien; DRKS); registration number: DRKS00032172; registration date: 11/07/2023 https://drks.de/search/de/trial/DRKS00032172.
Perception of the professional self-image by nurses and midwives. Psychometric adaptation of the Belimage questionnaire
Authors: Stadnicka Sabina Katarzyna , Zarzycka Danuta
Published: October 2023

Background

The aim of this paper is to present the research results on the perception of the professional self-image by Polish nurses and midwives as well as the psychometric adaptation of the Belimage scale.

Methods

A cross-sectional survey was conducted from January to November 2018. The study group consisted of 670 clinical practice nurses and midwives. A diagnostic survey method was applied using the Belimage questionnaire after it obtained acceptable psychometric properties through an adaptation procedure.

Results

In the group of respondents, the professional image of nurses and midwives is dominated by instrumental skills, documentation and organization of care, and communication skills. There is a statistically significant difference in the image of these two professions in terms of the ability to think and act creatively and critically, as well as innovation and evidence-based practice. The respondents' opinion regarding the perception of their image by themselves and society is statistically significant in each of the analyzed areas. In the professional image created by the public, nurses and midwives recognize that being a nurse/midwife is a vocation—277 (41.3%). However, in terms of their self-image, most nurses and midwives consider their work to be hard—442 (66%) and poorly paid—445 (66.4%). In the psychometric validation process, the Belimage questionnaire retained the original item structure, and the reliability of the subscales assessed with the Cronbach's alpha coefficient ranged from 0.845 to 0.730.

Conclusions

The professional image of nurses and midwives varies depending on the profession and the perspective of the assessment in relation to themselves and society. The study showed a particularly unfavorable social image of nurses and midwives, which significantly influences the outlook of nurses and midwives themselves on this issue.
A mixed-methods study of the awareness and functionality of sexual and reproductive health services among persons with disability in Ghana
Authors: Seidu Abdul-Aziz , Malau-Aduli Bunmi S. , McBain-Rigg Kristin , Malau-Aduli Aduli E. O. , Emeto Theophilus I.
Published: October 2023

Background

Persons with disabilities (PwDs) face barriers in accessing sexual and reproductive health (SRH) services due to lack of knowledge and awareness, stigma and discrimination, and inadequate service provision. This study aimed to examine the determinants of SRH knowledge and awareness among PwDs in Ghana, and to explore their perceptions of the functionality of SRH services.

Methods

A sequential explanatory mixed-methods study design was used to collect and analyse quantitative (n = 402) and qualitative (n = 37) data from PwDs in two districts in Ghana. Quantitative data were analysed using descriptive and inferential statistics, while qualitative data was analysed thematically.

Results

Most of the participants had high awareness of SRH (94.3%), sexually transmitted infections (STIs) (92.5%) and HIV/AIDS (97.0%). Employment status was positively associated with SRH awareness [aOR = 1.62; 95% CI = 1.02, 2.59]. Disability type was a significant predictor of STI [aOR = 2.02; 95% CI = 1.39, 2.94] and HIV/AIDS [aOR = 2.32; 95% CI = 1.21, 4.44] awareness, with the visually impaired having higher odds than the physically disabled. Age group was also a significant predictor of STI awareness, with older respondents having higher odds than younger ones [aOR = 1.76; CI = 1.01,3.05 for 30–39 years; aOR = 2.48; CI = 1.22, 5.05 for 40–49 years]. The qualitative findings revealed four main themes: conceptualisation of SRH, active engagement in SRH information seeking, tensions between knowledge and religious beliefs and perceived utility of SRH services.

Conclusion

Despite the high levels of SRH knowledge and awareness among PwDs, there are significant gaps and challenges related to disability type, age group, misconceptions, beliefs, and service non-functionality that limit the utility of SRH services. The findings call for tailored education to reduce misconceptions and put in pragmatic steps to deliver quality SRH services and information to PwDs. Further research is needed to assess the sexual lives of PwDs and explore the perspectives of all relevant stakeholders, including service providers and policymakers on how to enhance SRH outcomes for PwDs in Ghana.
Chromosome 1p36 candidate gene ZNF436 predicts the prognosis of neuroblastoma: a bioinformatic analysis
Authors: Wang Haiwei , Wang Xinrui , Xu Liangpu
Published: October 2023

Background

Genetic 1p deletion is reported in 30% of all neuroblastoma and is associated with the unfavorable prognosis of neuroblastoma. The expressions and prognosis of 1p candidate genes in neuroblastoma are unclear.

Methods

Public neuroblastoma cohorts were obtained for secondary analysis. The prognosis of 1p candidate genes in neuroblastoma was determined using Kaplan-Meier and cox regression analysis. The prediction of the nomogram model was determined using timeROC.

Results

First, we confirmed the bad prognosis of 1p deletion in neuroblastoma. Moreover, zinc finger protein 436 (ZNF436) located at 1p36 region was down-regulated in 1p deleted neuroblastoma and higher ZNF436 expression was associated with the longer event free survival and overall survival of neuroblastoma. The expression levels of ZNF436 were lower in neuroblastoma patients with MYCN amplification or age at diagnosis ≥ 18months, or with stage 4 neuroblastoma. ZNF436 had robust predictive values of MYCN amplification and overall survival of neuroblastoma. Furthermore, the prognostic significance of ZNF436 in neuroblastoma was independent of MYCN amplification and age of diagnosis. Combinations of ZNF436 with MYCN amplification or age of diagnosis achieved better prognosis. At last, we constructed a nomogram risk model based on age, MYCN amplification and ZNF436. The nomogram model could predict the overall survival of neuroblastoma with high specificity and sensitivity.

Conclusions

Chromosome 1p36 candidate gene ZNF436 was a prognostic maker of neuroblastoma.
The pipeline for drugs for control and elimination of neglected tropical diseases: 2. Oral anti-infective drugs and drug combinations for off-label use
Authors: Pfarr Kenneth M. , Krome Anna K. , Al-Obaidi Issraa , Batchelor Hannah , Vaillant Michel , Hoerauf Achim , Opoku Nicholas O. , Kuesel Annette C.
Published: October 2023

In its ‘Road map for neglected tropical diseases 2021–2030’, the World Health Organization outlined its targets for control and elimination of neglected tropical diseases (NTDs) and research needed to achieve them. For many NTDs, this includes research for new treatment options for case management and/or preventive chemotherapy. Our review of small-molecule anti-infective drugs recently approved by a stringent regulatory authority (SRA) or in at least Phase 2 clinical development for regulatory approval showed that this pipeline cannot deliver all new treatments needed. WHO guidelines and country policies show that drugs may be recommended for control and elimination for NTDs for which they are not SRA approved (i.e. for ‘off-label’ use) if efficacy and safety data for the relevant NTD are considered sufficient by WHO and country authorities. Here, we are providing an overview of clinical research in the past 10 years evaluating the anti-infective efficacy of oral small-molecule drugs for NTD(s) for which they are neither SRA approved, nor included in current WHO strategies nor, considering the research sponsors, likely to be registered with a SRA for that NTD, if found to be effective and safe. No such research has been done for yaws, guinea worm, Trypanosoma brucei gambiense human African trypanosomiasis (HAT), rabies, trachoma, visceral leishmaniasis, mycetoma, T. b. rhodesiense HAT, echinococcosis, taeniasis/cysticercosis or scabies. Oral drugs evaluated include sparfloxacin and acedapsone for leprosy; rifampicin, rifapentin and moxifloxacin for onchocerciasis; imatinib and levamisole for loiasis; itraconazole, fluconazole, ketoconazole, posaconazole, ravuconazole and disulfiram for Chagas disease, doxycycline and rifampicin for lymphatic filariasis; arterolane, piperaquine, artesunate, artemether, lumefantrine and mefloquine for schistosomiasis; ivermectin, tribendimidine, pyrantel, oxantel and nitazoxanide for soil-transmitted helminths including strongyloidiasis; chloroquine, ivermectin, balapiravir, ribavirin, celgosivir, UV-4B, ivermectin and doxycycline for dengue; streptomycin, amoxicillin, clavulanate for Buruli ulcer; fluconazole and isavuconazonium for mycoses; clarithromycin and dapsone for cutaneous leishmaniasis; and tribendimidine, albendazole, mebendazole and nitazoxanide for foodborne trematodiasis. Additional paths to identification of new treatment options are needed. One promising path is exploitation of the worldwide experience with ‘off-label’ treatment of diseases with insufficient treatment options as pursued by the ‘CURE ID’ initiative.

Graphical abstract
DeepGAMI: deep biologically guided auxiliary learning for multimodal integration and imputation to improve genotype–phenotype prediction
Authors: Chandrashekar Pramod Bharadwaj , Alatkar Sayali , Wang Jiebiao , Hoffman Gabriel E. , He Chenfeng , Jin Ting , Khullar Saniya , Bendl Jaroslav , Fullard John F. , Roussos Panos , Wang Daifeng
Published: October 2023

Background

Genotypes are strongly associated with disease phenotypes, particularly in brain disorders. However, the molecular and cellular mechanisms behind this association remain elusive. With emerging multimodal data for these mechanisms, machine learning methods can be applied for phenotype prediction at different scales, but due to the black-box nature of machine learning, integrating these modalities and interpreting biological mechanisms can be challenging. Additionally, the partial availability of these multimodal data presents a challenge in developing these predictive models.

Method

To address these challenges, we developed DeepGAMI, an interpretable neural network model to improve genotype–phenotype prediction from multimodal data. DeepGAMI leverages functional genomic information, such as eQTLs and gene regulation, to guide neural network connections. Additionally, it includes an auxiliary learning layer for cross-modal imputation allowing the imputation of latent features of missing modalities and thus predicting phenotypes from a single modality. Finally, DeepGAMI uses integrated gradient to prioritize multimodal features for various phenotypes.

Results

We applied DeepGAMI to several multimodal datasets including genotype and bulk and cell-type gene expression data in brain diseases, and gene expression and electrophysiology data of mouse neuronal cells. Using cross-validation and independent validation, DeepGAMI outperformed existing methods for classifying disease types, and cellular and clinical phenotypes, even using single modalities (e.g., AUC score of 0.79 for Schizophrenia and 0.73 for cognitive impairment in Alzheimer’s disease).

Conclusion

We demonstrated that DeepGAMI improves phenotype prediction and prioritizes phenotypic features and networks in multiple multimodal datasets in complex brains and brain diseases. Also, it prioritized disease-associated variants, genes, and regulatory networks linked to different phenotypes, providing novel insights into the interpretation of gene regulatory mechanisms. DeepGAMI is open-source and available for general use.
Efficacy and safety of allogeneic umbilical cord-derived mesenchymal stem cells for the treatment of complex perianal fistula in Crohn’s disease: a pilot study
Authors: Wei Juan , Zhang Yufei , Chen Chunyan , Feng Xiaoyue , Yang Zhao , Feng Jing , Jiang Qiong , Fu Jinjin , Xuan Ji , Gao Hong , Liao Lianming , Wang Fangyu
Published: October 2023

Objectives

The aim of the study was to evaluate the efficacy and safety of allogeneic umbilical cord-derived mesenchymal stem cells (TH-SC01) for complex perianal fistula in patients with Crohn’s disease (CD).

Methods

This was an open-label, single-arm clinical trial conducted at Jinling Hospital. Adult patients with complex treatment-refractory CD perianal fistulas (pfCD) were enrolled and received a single intralesional injection of 120 million TH-SC01 cells. Combined remission was defined as an absence of suppuration through an external orifice, complete re-epithelization, and absence of collections larger than 2 cm measured by magnetic resonance imaging (MRI) at 24 weeks after cell administration.

Results

A total of 10 patients were enrolled. Six patients (60.0%) achieved combined remission at 24 weeks. The number of draining fistulas decreased in 9 (90.0%) and 7 (70.0%) patients at weeks 12 and 24, respectively. Significant improvement in Perianal Crohn Disease Activity Index, Pelvic MRI-Based Score, Crohn Disease Activity Index, and quality of life score were observed at 24 weeks. No serious adverse events occurred. The probability of remaining recurrence-free was 70% at week 52.

Conclusion

The study demonstrated that local injection of TH-SC01 cells might be an effective and safe treatment for complex treatment-refractory pfCD after conventional and/or biological treatments fail (ClinicalTrials.gov ID, NCT04939337).

Trial Registration: The study was retrospectively registered on www.ClinicalTrials.gov (NCT04939337) on June 25, 2021.
A new type of Szász–Mirakjan operators based on q-integers
Authors: Sabancigil Pembe , Mahmudov Nazim , Dagbasi Gizem
Published: October 2023

In this article, by using the notion of quantum calculus, we define a new type Szász–Mirakjan operators based on the q-integers. We derive a recurrence formula and calculate the moments $\Phi _{n,q}(t^{m};x)$

Φ

n
,
q

(

t
m

;
x
)
for $m=0,1,2$
m
=
0
,
1
,
2
and the central moments $\Phi _{n,q}((t-x)^{m};x)$

Φ

n
,
q

(

(
t
−
x
)

m

;
x
)
for $m=1,2$
m
=
1
,
2
. We give estimation for the first and second-order central moments. We present a Korovkin type approximation theorem and give a local approximation theorem by using modulus of continuity. We obtain a local direct estimate for the new Szász–Mirakjan operators in terms of Lipschitz-type maximal function of order α. Finally, we prove a Korovkin type weighted approximation theorem.
Feasibility of a community-adapted multi-domain intervention for dementia prevention among older adults: a research protocol
Authors: Kuroda Yujiro , Fujita Kosuke , Sugimoto Taiki , Uchida Kazuaki , Shimazu Taichi , Saito Junko , Arai Hidenori , Sakurai Takashi
Published: October 2023

Background

Multi-domain interventions effectively prevent dementia in clinical settings; however, their efficacy within local communities is unclear. This study assesses the feasibility of an adapted multi-domain intervention for dementia prevention in community-dwelling older adults.

Methods

The single-arm trial enrolls 60 participants from two Obu City communities, Japan. Primary outcome: participant retention in the adapted multi-domain intervention; secondary outcomes: health and implementation outcomes. Over 12 months, a team of researchers and public health nurse oversees the study in the first half, gradually shifting the management to public health nurses in the second half. Using the Framework for Reporting Adaptations and Modifications-Enhanced, the clinical programme is adjusted for the local community. It includes a 60-minute exercise and 30-minute group sessions, targeting lifestyle, diet, and social participation.

Discussion

This pioneer study evaluates the feasibility of an adapted intervention programme for dementia prevention in a community setting. Challenges in disseminating dementia prevention programmes warrant further investigation into effective implementation as well as strategies and methods to appeal to the target population. Upon confirming this programme’s feasibility, future studies can further evaluate its broader effectiveness.

Trial registration

The protocol is registered with the Clinical Trials Registry (UMIN-CTR) of the University Hospital’s Medical Information Network, under registration number UMIN000050581.
A randomized controlled trial comparing conservative versus surgical treatment in patients with foot drop due to peroneal nerve entrapment: results of an internal feasibility pilot study
Authors: Oosterbos Christophe , Rummens Sofie , Bogaerts Kris , Van Hoylandt Anaïs , Hoornaert Sophie , Weyns Frank , Dubuisson Annie , Ceuppens Jeroen , Schuind Sophie , Groen Justus L , Lemmens Robin , Theys Tom
Published: October 2023

Background

Based on the lack of literature to support any treatment strategy in patients with foot drop due to peroneal nerve entrapment, a prospective study randomizing patients between surgery and conservative treatment is warranted. Since studies comparing surgery to no surgery are often challenging, we first examined the feasibility of such a randomized controlled trial.

Methods/design

An internal feasibility pilot study was conducted to assess several aspects of process, resource, management, and scientific feasibility. The main objective was the assessment of the recruitment rate. The criterion to embark on a full study was the recruitment of at least 14 patients in 6 participating centers within 6 months. Cross-over rate, blinding measures, training strategies, and trial assessments were evaluated. The trial was entirely funded by the KCE Trials public funding program of the Belgian Health Care Knowledge Centre (ID KCE19-1232).

Results

The initial duration was prolonged due to the COVID-19 pandemic. Between April 2021 and October 2022, we included 19 patients of which 15 were randomized. Fourteen patients were treated as randomized. One drop-out occurred after randomization, prior to surgery. We did not document any cross-over or accidental unblinding. Training strategies were successful. Patients perceived the quality of life questionnaire as the least relevant assessment. Assessment of ankle dorsiflexion range of motion was prone to interobserver variability. All other trial assessments were adequate.

Discussion

Recruitment of the anticipated 14 patients was feasible although slower than expected. The Short-Form Health Survey (SF-36) and assessment of ankle dorsiflexion range of motion will no longer be included in the full-scale FOOTDROP trial.

Conclusion

The FOOTDROP study is feasible.

Trial registration

ClinicalTrials.gov, identifier NCT04695834. Registered 4 January 2021.
Osimertinib-induced biventricular cardiomyopathy with abnormal cardiac MRI findings: a case report
Authors: Patel Karishma , Hsu Kristie Y. , Lou Kevin , Soni Krishan , Lee Yoo Jin , Mulvey Claire K. , Baik Alan H.
Published: October 2023

Background

Osimertinib is a third-generation epidermal growth factor receptor (EGFR) inhibitor that is currently the first-line treatment for metastatic EGFR-mutated non-small-cell lung cancer (NSCLC) due to its favorable efficacy and tolerability profile compared to previous generations of EGFR inhibitors. However, it can cause uncommon, yet serious, cardiovascular adverse effects.

Case Presentation

We present the case of a 63-year-old man with EGFR-mutated NSCLC treated with osimertinib who developed new-onset non-ischemic cardiomyopathy with biventricular dysfunction and heart failure in the context of an enlarging pericardial effusion. For the first time, we demonstrate cardiac MR imaging findings associated with osimertinib-associated cardiomyopathy, including focal late gadolinium enhancement and myocardial edema. The patient’s biventricular function normalized after initiation of goal-directed medical therapy for heart failure and holding osimertinib. The patient was subsequently started on afatinib, a second-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), without recurrence of cardiomyopathy.

Conclusions

This case highlights the need to better understand osimertinib-induced cardiotoxicity and strategies to optimize oncologic care in patients who develop severe cardiac toxicities from cancer therapy. It further underlines the importance of specialized multidisciplinary care of cancer patients who develop cardiotoxicities to optimize their oncologic outcomes.