bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and Characterization of Soluble Silyl End‐capped Arene‐Thiophene Co‐Oligomers
Authors: Choi Jung Hei , Kim Eunae , Yoon Ung Chan , Lee Hyang‐Yeol
Published: July 2015

Soluble dimethyl‐n‐octylsilyl end‐capped arene‐thiophene oligomers with the central unit including phenyl, biphenyl, fluorine, and naphthalene were synthesized by Stille reaction. The optical, electrochemical, and thermal properties of the oligomers were then measured. The absorption maxima of the arene‐thiophene oligomers in dilute solutions were close to that obtained for
DSi‐4T
(λabs = 403 nm). They exhibited well‐resolved fluorescence spectra in solution with emission maxima at 445, 446, 448, and 450 nm for
DSi‐TTPTT
,
DSi‐TTPPTT
,
DSi‐TTFTT
, and
DSi‐TTNTT
, respectively. The highest occupied molecular orbital (HOMO) energy levels were determined to be −5.29, −5.33, −5.27 and −5.29 eV, respectively; therefore all co‐oligomers displayed a lower HOMO energy level than the −5.14 eV of
DSi‐6T
. The thermal stability of the arene‐thiophene oligomers was investigated by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA). Except for
DSi‐TTPTT
, the TGA results showed a 5% weight loss at around 400 °C, which indicates high thermal stability. Dimethyl‐n‐octylsilyl end substituents allowed solution processability due to their high solubility. Overall, the electrochemical analysis of arene‐thiophene oligomers indicated superior oxidative stability to
DSi‐6T
.
Improvement of the Crystallinity of MgZnO with a Zn Buffer Layer by Sol–Gel Spin‐coating Method
Authors: Ji Iksoo , Kim Younggyu , Kim Yangsoo , Leem Jae‐Young
Published: July 2015

We fabricate magnesium zinc oxide (MZO) thin films inserting a buffer layer between a film and a substrate with different annealing temperatures. The structural and optical properties of MZO thin films are investigated by using scanning electron microscopy, X‐ray diffraction (XRD), and photoluminescence. The XRD patterns for the buffer layers annealed at 200 °C show the narrowest full width at half maximum and the most intense (0 0 2) diffraction peak. In addition, the buffer layers decrease the magnitude of the residual stress between the MZO thin film and the silicon substrate. The near‐band‐edge emission peaks intensify and the deep‐level emission peaks significantly intensify with increasing buffer layer annealing temperatures. Inserting a buffer layer between a film and a substrate improves the crystallinity of MZO thin films.
Matrix Infrared Spectra and Density Functional Calculations of CH2Cl–Cl and CH2Br–Br Produced by Laser‐ablated Metal Plume Irradiation
Authors: Cho Han‐Gook , Andrews Lester
Published: July 2015

CH2Cl–Cl and CH2Br–Br, photoisomers of CH2Cl2
and CH2Br2
, were identified in the matrix IR spectra from the precursors exposed to plume radiation of a laser‐ablated transition metal. On the other hand, the corresponding photoisomers of CH2F2
and CH2FCl (CH2F–F, CH2F–Cl, and CH2Cl–F) were not observed because of their instabilities. The CX bond of the product is unusually strong, leading to a high CX stretching frequency. Natural bond orbital (NBO) analysis reveals that it is a true carbon–halogen double bond; in contrast, the XX bond is largely ionic (H2CXδ+
∙∙∙Xδ−
), similar to the previously studied analogs from tri‐ and tetrahalomethanes. Intrinsic reaction coordinate (IRC) computation reproduces the smooth interconversion between the precursor and the energetically higher photoisomer, consistent with the disappearance of the product during visible photolysis.
Elucidating Adsorption Mechanisms of Phthalate Esters upon Carbon Nanotubes/Graphene and Natural Organic Acid Competitive Effects in Water by DFT and MD Calculations
Authors: Wang Zhuang , Wang Se , Chen Mindong , Xu Defu , Tang Lili , Wang Degao
Published: July 2015

Simulations at multiple levels were performed to investigate the aqueous adsorption of phthalate esters (PAEs) on carbon nanoparticles and to find the competitive effect of a low molecular weight natural organic acid (benzoic acid) on the adsorption process. Six PAEs of varying alkyl side chain lengths and three carbon‐based nanomaterials including a single‐walled carbon nanotube (SWNT), double‐walled carbon nanotube (DWNT), and graphene (G) were studied. Results showed that the adsorption energies calculated using density functional theory increase with increasing length of the PAE alkyl chain. G exhibits higher adsorption capacity for the PAEs than SWNT and DWNT. The absolute adsorption energies of these systems also display a positive linear correlation with the hydrophobicity of the PAE molecules. Molecular dynamics simulations indicate that the presence of neutral/anionic benzoic acid in water alleviates the PAE adsorption. Furthermore, anionic benzoic acid exerts more impact on the PAE adsorption than the neutral form.
Temperature‐dependent Variations of the Interface between UO2 and Zr
Authors: Youn Young‐Sang , Kim Jong‐Goo , Park Soon Dal , Ha Yeong‐Keong
Published: July 2015

Temperature‐dependent variations of the interface between uranium dioxide and zirconium in UO2
‐Zr systems were studied using X‐ray photoelectron spectroscopy. The surface of the uranium dioxide sample was oxidized to hyperstoichiometric UO
2+x
composed of U(IV), U(V), and U(VI) valence states at room temperature, whereas UO2
consisting of the only U(IV) oxidation state appeared after annealing with zirconium. In the zirconium sample, its surface was spontaneously oxidized to ZrO2
at room temperature, whereas it was variously changed after heating the UO2
‐Zr sample. Furthermore, we observed a molten product composed of α‐Zr(O), (U,Zr)O2
, and ZrO2
when a UO2
‐Zr sample was fully melted.
Development and validation of a UPLC‐MS/MS method for the determination of cucurbitacin B in rat plasma and application to a pharmacokinetic study
Authors: Zhao Waiou , Xu Dahai , Yan Weiwei , Wang Yushi , Zhang Nan
Published: July 2015

Cucurbitacin B (CuB), one of the most abundant forms of cucurbitacins, is a promising natural anticancer drug candidate. Although the anticancer activity of CuB has been well demonstrated, information regarding the pharmacokinetics is limited. A rapid, selective and sensitive UPLC‐MS/MS for CuB was developed and validated using hemslecin A (HeA) as internal standard (IS). Plasma samples were pre‐treated by liquid–liquid extraction with dichloromethane. Separation was achieved on a reversed‐phase C18 column (50 × 4.6 mm, 5 µm) at 35°C using isocratic elution with water–methanol (25:75, v/v) at a flow rate of 0.3 mL/min. The analytes were monitored by a triple quadrupole tandem mass spectrometer with positive electrospray ionization mode. The calibration curve was linear (r > 0.995) in a concentration range of 0.3–100 ng/mL with a limit of quantification of 0.3 ng/mL. Intra‐ and inter‐day accuracy and precision were validated by percentage relative error and relative standard deviation, respectively, which were both lower than the limit of 15%. This assay was successfully applied to a pharmacokinetic study of CuB in Wistar rats. Copyright © 2015 John Wiley & Sons, Ltd.
Effect of the Carbon Support on the Catalytic Activity of Ruthenium‐Magnetite Catalysts for p‐Chloronitrobenzene Hydrogenation
Authors: Bertolucci Elisa , Bacsa Revathi , Benyounes Anas , Raspolli‐Galletti Anna M. , Axet M. Rosa , Serp Philippe
Published: July 2015

Few‐layer graphene, carbon nanotubes, and N‐doped carbon nanotubes have been used to support Ru and/or Fe3O4 nanoparticles. The materials were prepared by a new single‐step sustainable method that involves: 1) a simple procedure, 2) the use of propanol as a solvent, 3) short reaction times, 4) an efficient and energy‐saving heat source, and 5) the absence of any high‐boiling‐point stabilizing agent or organic surfactant. The supported nanoparticles were characterized by TEM, XRD, inductively coupled plasma optical emission spectroscopy, and SQUID magnetometer analyses and employed in the selective hydrogenation of p‐chloronitrobenzene to p‐chloroaniline with very promising results. The hydrogenation runs evidence the marked influence of the diverse carbon nanostructures on the reaction rate, and highlights the promising activity of nanocatalysts supported on few‐layer graphene.
Multiscale Coupling of Pore Structure Evolution with Decomposition Kinetics of Limestone
Authors: Li Mingchun , Song Lanting , Wu Yusheng
Published: July 2015

The pore structure evolution and reaction characteristics of limestone with different particle sizes during thermal decomposition were investigated experimentally. A kinetic model considering the effect of pore structure evolution was developed to simulate the multiscale coupling of the mesoscale pore structure with the macroscopic transport and microscopic chemical reaction. Over a defined particle size range, the calculated results were in good agreement with the experimental data including the influence of gas diffusion throughout the whole decomposition course. A dimensionless Thiele modulus Th was constructed for assessing the critical point corresponding to the transformation of controlled mechanisms.
A Platinum–Vanadium Nitride/Porous Graphitic Nanocarbon Composite as an Excellent Catalyst for the Oxygen Reduction Reaction
Authors: Yin Jie , Wang Lei , Yu Peng , Zhao Lu , Tian Chungui , Jiang Baojiang , Zhao Dongdong , Zhou Wei , Fu Honggang
Published: July 2015

The oxygen reduction reaction (ORR) is a crucial process not only in fuel cells, but also in metal–air batteries, thus its electrocatalysts have attracted considerable attention. Here, we report the use of a vanadium nitride/porous graphitic nanocarbon (VN/PGNC) composite as an efficient support for a platinum electrocatalyst towards ORR. The VN/PGNC composite was synthesized through a gel‐coordination pyrolytic route. The gelatinous precursor formed by the coordination of VO3−, Ni2+, tetraethyl orthosilicate (TEOS), and glucose, followed by a carbonization–nitridation and a subsequent acid‐treatment process, led to the formation of the VN/PGNC composite with a large surface area of 879.0 m2 g−1. The synthetic 10 % Pt–VN/PGNC catalyst exhibited excellent ORR performance with more positive onset potential (1.02 V), 1.2 times higher mass activity (135.5 mA mg−1), 0.4 times higher specific activity (4.15 mA cm−2), and better cyclic stability compared with the commercial 20 % Pt/C catalyst. The 10 % Pt–VN/PGNC catalyst mainly exhibits a four‐electron pathway. The excellent performance of 10 % Pt–VN/PGNC catalyst is attributed to the porous structure of the support, which facilitates strong synergistic effects between the Pt and VN nanoparticles. The present work provides a cost‐effective route for the synthesis of the efficient ORR catalyst, which could promote the development of fuel cells.
Tunable Keplerate Type‐Cluster “Mo132” Cavity with Dicarboxylate Anions
Authors: Lai Thanh‐Loan , Awada Mouhamad , Floquet Sébastien , Roch‐Marchal Catherine , Watfa Nancy , Marrot Jérôme , Haouas Mohamed , Taulelle Francis , Cadot Emmanuel
Published: July 2015

The internal functionalization of the Keplerate‐type capsule Mo132 has been carried out by ligand exchange leading to the formation of glutarate and succinate containing species isolated as ammonium or dimethylammonium salts. Solution NMR analysis is consistent with asymmetric inner dicarboxylate ions containing one carboxylato group grafted onto the inner side of the spheroidal inorganic shell while the second hangs toward the center of the cavity. Such a disposition has been confirmed by the single‐crystal X‐ray diffraction analysis of the glutarate containing {Mo132} species. A detailed NMR solution study of the ligand‐exchange process allowed determining the binding constant KL of acetate (AcO−), succinate (HSucc−) or glutarate (HGlu−) ligands at the 30 inner coordinating sites, which vary such as K<K<K‐supported by the associated thermodynamic parameters ΔrS* and ΔrH*. Such a variation is mainly explained by a positive entropic gain attenuated by unfavorable steric effect. Furthermore, these results are completed by 1H DOSY and 1H EXSY NMR experiments which are in agreement with bulky guests firmly trapped within the cavity. At last, variable temperature 1H NMR study below 290 K revealed a striking line broadening occurring abruptly within a 5 K range. Such an effect appears closely related to the presence of the ammonium cations suspected to be present within the cavity and then has been interpreted as an inner‐phase transition leading to a frozen state.
Coupling‐Reagent‐Free Synthesis of Dipeptides and Tripeptides Using Amino Acid Ionic Liquids
Authors: Furukawa Shinya , Fukuyama Takahide , Matsui Akihiro , Kuratsu Mai , Nakaya Ryotaro , Ineyama Takashi , Ueda Hiroshi , Ryu Ilhyong
Published: July 2015

A general method for the synthesis of dipeptides has been developed, which does not require any coupling reagents. This method is based on the reaction of readily available HCl salts of amino acid methyl esters with tetrabutylphosphonium amino acid ionic liquids. The isolation procedure of stepwise treatment with AcOH is easy to carry out. The method was extended to the synthesis of tripeptide, tyrosyl‐glycyl‐glycine, present in IMREG‐1, also.
Click Modification of Diazido Acridine Intercalators: A Versatile Route towards Decorated DNA Nanostructures
Authors: Moradpour Hafshejani Shahrbanou , Watson Scott M. D. , Tuite Eimer M. , Pike Andrew R.
Published: July 2015

Diazido derivatives of 3,6‐diamino acridine (proflavine) intercalate into DNA and undergo functionalization through click chemistry to form 1D nanostructures with redox active, conductive nanowire, and fluorescent properties. This two‐step approach, intercalation followed by click modification allows for the controlled decoration of DNA nanostructures.
Activation of Carbon Dioxide by Silyl Triflate‐Based Frustrated Lewis Pairs
Authors: Weicker Sarah A. , Stephan Douglas W.
Published: July 2015

Silyl triflates of the form R4−nSi(OTf)n (n=1, 2; OTf=OSO3CF3) are shown to activate carbon dioxide when paired with bulky alkyl‐substituted Group 15 bases. Combinations of silyl triflates and 2,2,6,6‐tetramethylpiperidine react with CO2 to afford silyl carbamates via a frustrated Lewis pair‐type mechanism. With trialkylphosphines, the silyl triflates R3Si(OTf) reversibly bind CO2 affording [R′3P(CO2)SiR3][OTf] whereas when Ph2Si(OTf)2 is used one or two molecules of CO2 can be sequestered. The latter bis‐CO2 product is favoured at low temperatures and by excess phosphine.
Synthesis of Air‐ and Moisture‐Stable, Storable Chiral Oxorhenium Complexes and Their Application as Catalysts for the Enantioselective Imine Reduction
Authors: Das Braja Gopal , Nallagonda Rajender , Dey Dhananjay , Ghorai Prasanta
Published: July 2015

Air‐/moisture‐stable, crystalline, and storable chiral salicyloxazoline based oxorhenium(V) complexes have been synthesized and their catalytic application for the asymmetric reduction of ketimines using hydrosilane as hydride source is disclosed. A broad substrate scope, high yields, and excellent enantioselectivities (up to 99 %) are attained. Furthermore, the syntheses of enantiopure α‐amino esters, γ‐ and δ‐lactams, and isoindolinones have also been carried out using this methodology. Finally, the method has been applied to synthetic targets of pharmaceutical relevance, such as R‐(+)‐salsolidine and R‐(+)‐crispine A.
Base‐Promoted/Gold‐Catalyzed Intramolecular Highly Selective and Controllable Detosylative Cyclization
Authors: Zhu Chenghao , Qiu Lin , Xu Guangyang , Li Jian , Sun Jiangtao
Published: July 2015

A highly selective, controllable and synthetically useful base‐promoted intramolecular detosylative cyclization of bis‐N‐tosylhydrazones has been achieved, affording N‐containing heterocycles and cyclic olefins under transition‐metal‐free or gold‐catalyzed procedures, respectively. Moreover, an effective and practical metal‐free or gold‐catalyzed approach to synthesize polycyclic aromatic compounds is also reported.
A Bioinspired Catalytic Aerobic Oxidative CH Functionalization of Primary Aliphatic Amines: Synthesis of 1,2‐Disubstituted Benzimidazoles
Authors: Nguyen Khac Minh Huy , Largeron Martine
Published: July 2015

Aerobic oxidative CH functionalization of primary aliphatic amines has been accomplished with a biomimetic cooperative catalytic system to furnish 1,2‐disubstituted benzimidazoles that play an important role as drug discovery targets. This one‐pot atom‐economical multistep process, which proceeds under mild conditions, with ambient air and equimolar amounts of each coupling partner, constitutes a convenient environmentally friendly strategy to functionalize non‐activated aliphatic amines that remain challenging substrates for non‐enzymatic catalytic aerobic systems.
ChemInform Abstract: NaTi3FeO8: A Novel Anode Material for Sodium‐Ion Batteries.
Authors: Hou Junke , Niu Yubin , Yi Fenglian , Liu Sangui , Li Yutao , He Hong , Xu Maowen
Published: July 2015

NaTi3FeO8 is prepared by calcination of stoichiometric amounts of Na2CO3, Fe2O3, and TiO2 in air (950 °C, 12 h).
ChemInform Abstract: Ruthenium‐Oxide‐Coated Sodium Vanadium Fluorophosphate Nanowires as High‐Power Cathode Materials for Sodium‐Ion Batteries.
Authors: Peng Manhua , Li Biao , Yan Huijun , Zhang Dongtang , Wang Xiayan , Xia Dingguo , Guo Guangsheng
Published: July 2015

RuO2‐coated Na3V2O2(PO4)2F nanowires are prepared by hydrothermal reaction of a microemulsion formed by combining an aqueous solution of oxalic acid, NaF, NH4H2PO4, and NH4VO3 with a mixture of cetyltrimethylammonium bromide, H2O, cyclohexanone, and n‐pentanol (autoclave, pH 2‐3 adjusted with HNO3, 180 °C, 24 h).
ChemInform Abstract: Synthesis of the Layered Quaternary Uranium‐Containing Oxide Cs2Mn3U6O22 and Characterization of Its Magnetic Properties.
Authors: Read Cory M. , Gordon Elijah E. , Smith Mark D. , Yeon Jeongho , Morrison Gregory , Whangbo Myung‐Hwan , zur Loye Hans‐Conrad
Published: July 2015

Single crystals of the title compound are prepared by reaction of MnCl2 and U3O8 in a CsCl flux (alumina crucible, 900 °C, 9 h, 40% yield).
ChemInform Abstract: Heterometallic Sulfide Cluster [Ag6Sn6S20]10‐: Solvothermal Syntheses and Characterizations of Silver Thiostannates with Lanthanide Complex Counter Cations.
Authors: Han Jingyu , Liu Yun , Lu Jialin , Tang Chunying , Wang Fang , Shen Yali , Zhang Yong , Jia Dingxian
Published: July 2015

The new hybrid silver thiostannates (enH)4[Ln(en)4]2 [Ag6Sn6S20]·3en (Ln: Er, Tm, Yb) are solvothermally prepared from mixtures of Ln2O3, Ag, Sn, and S in en (180 °C, 6 d).
ChemInform Abstract: Selective Oxidation with Aqueous Hydrogen Peroxide by [PO4{WO(O2)2}4]3‐ Supported on Zinc‐Modified Tin Dioxide.
Authors: Nojima Susumu , Kamata Keigo , Suzuki Kosuke , Yamaguchi Kazuya , Mizuno Noritaka
Published: July 2015

The newly developed heterogeneous catalyst allows for the expedient and effective oxidation of a diverse range of alkenes to epoxides, of pyridines to pyridine oxides, of dialkylamines to nitrones, of silanes to silanols, and of sulfides to sulfoxides or sulfones.
ChemInform Abstract: Rh(III)‐Catalyzed and Alcohol‐Involved Carbenoid C—H Insertion into N‐Phenoxyacetamides Using α‐Diazomalonates.
Authors: Zhou Jie , Shi Jingjing , Liu Xuelei , Jia Jinlong , Song Huacan , Xu H. Eric , Yi Wei
Published: July 2015

The presented approach provides a straightforward process for installing both an α‐quaternary carbon center and a free‐OH moiety into the phenyl ring.
ChemInform Abstract: Cp2TiCl2‐Catalyzed cis‐Hydroalumination of Propargylic Amines with Red‐Al: Stereoselective Synthesis of Z‐Configured Allylic Amines.
Authors: Sun Renhong , Liu Jun , Yang Shuang , Chen Ming , Sun Ning , Chen Haoyi , Xie Xin , You Xu , Li Shi , Liu Yuanhong
Published: July 2015

A titanium‐catalyzed cis‐hydroalumination of propargylic amines with Red‐Al is described.
ChemInform Abstract: An Odorless Thia‐Michael Addition Using Bunte Salts as Thiol Surrogates.
Authors: Lin Ya‐mei , Lu Guo‐ping , Cai Chun , Yi Wen‐bin
Published: July 2015

The synthesis of various β‐sulfido carbonyl compounds via hydrolysis of Bunte salts is described.
ChemInform Abstract: Formal Asymmetric Catalytic Thiolation with a Bifunctional Catalyst at a Water‐Oil Interface: Synthesis of Benzyl Thiols.
Authors: Guo Wengang , Wu Bo , Zhou Xin , Chen Ping , Wang Xu , Zhou Yong‐Gui , Liu Yan , Li Can
Published: July 2015

The enantioselective conjugated addition of tritylthiol to in situ generated ortho‐quinone methides in the presence of a squaramide organocatalyst is studied.
ChemInform Abstract: Nickel‐Catalyzed Monoarylation of Ammonia.
Authors: Borzenko Andrey , Rotta‐Loria Nicolas L. , MacQueen Preston M. , Lavoie Christopher M. , McDonald Robert , Stradiotto Mark
Published: July 2015

Substrates are mainly used as chlorides, but bromides or tosylates are also suitable in the chemoselective transformations which are promoted by the Ni/Josiphos system.
ChemInform Abstract: Effect of BF3 on the Enantioselective Reduction of Trifluoromethyl Ketones Using a Chiral Lactam Alcohol with Borane.
Authors: Harauchi Yuki , Takakura Chihiro , Furumoto Toshio , Yanagita Ryo C. , Kawanami Yasuhiro
Published: July 2015

In comparison to previously reported methods, the described procedure offers an improved reproducibility and practicability.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative Sonogashira Coupling Between Aryl Triazenes and Alkynes.
Authors: Li Wanfang , Wu Xiao‐Feng
Published: July 2015

The title reaction works with readily available aryl triazenes and alkynes as substrates and methanesulfonic acid as the additive to afford a series of α,β‐ynones in good yields.
ChemInform Abstract: The Nickel(II)‐Catalyzed Direct Benzylation, Allylation, Alkylation, and Methylation of C—H Bonds in Aromatic Amides Containing an 8‐Aminoquinoline Moiety as the Directing Group.
Authors: Aihara Yoshinori , Wuelbern Jendrik , Chatani Naoto
Published: July 2015

The nickel(II)‐catalyzed ortho‐alkylation of aromatic amides containing an 8‐aminoquinoline moiety as directing group is described.
ChemInform Abstract: Iodine‐Induced Synthesis of Sulfonate Esters from Sodium Sulfinates and Phenols under Mild Conditions.
Authors: Gao Jian , Pan Xiaojun , Liu Juan , Lai Junyi , Chang Liming , Yuan Gaoqing
Published: July 2015

Sulfonate esters are simply, efficiently, and eco‐friendly synthesized from sodium sulfinates and phenols by a mild, metal‐free and inexpensive procedure.
ChemInform Abstract: PtI2‐Catalyzed Cyclization of 3‐Acyloxy‐1,5‐enynes with the Elimination of HOAc and a Benzyl Shift: Synthesis of Unsymmetrical m‐Terphenyls.
Authors: Huang Kaimeng , Ke Xiaona , Wang Hongkai , Wang Junying , Zhou Chenchen , Xu Xiufang , Liu Lingyan , Li Jing
Published: July 2015

The utility of the method is exemplified by the preparation of a photoelectrically interesting multiphenyl compound [cf.
ChemInform Abstract: Synthesis of Novel Macrocyclic Planar Chiral Carbene—Ag Complexes Derived from [2.2]Paracyclophane for Rh‐Catalyzed Asymmetric 1,2‐Additions of Arylboronic Acids to Aromatic Aldehydes.
Authors: Chen Jianqiang , Yang Shaobo , Chen Zhen , Song Chun , Ma Yudao
Published: July 2015

The reaction tolerates a variety of substituted aryl aldehydes and aryl boronic acids, and the products are obtained in good to excellent yields with moderate enantiomeric excess.
ChemInform Abstract: Diastereoselective Tandem Reactions of Substituted 3‐Sulfolenes with Bis‐vinyl Ketones Leading to Highly Functionalized Bicyclic and Tricyclic Frameworks.
Authors: Brant Michael G. , Friedmann Jordan N. , Bohlken Connor G. , Oliver Allen G. , Wulff Jeremy E.
Published: July 2015

Upon variation of the steric and electronic properties of the starting sulfolenes four unique bi‐ or tricyclic ring‐systems are constructed as single diastereomers with up to five stereogenic centers.
ChemInform Abstract: Quinone Methides as [1, 5]‐Hydride Acceptors: Approach to N‐Aryl Pyrroles.
Authors: Zhen Le , Lin Chao , Du Hong‐Jin , Dai Liang , Wen Xiaoan , Xu Qing‐Long , Sun Hongbin
Published: July 2015

O‐Alkylated quinone methides are used as hydride acceptors in the [1,5]‐hydride shift reaction of N‐aryl pyrrolines (I) to the corresponding pyrrole derivatives (II).
ChemInform Abstract: Exploring the Catalytic Potential of ZIF‐90: Solventless and Co‐Catalyst‐Free Synthesis of Propylene Carbonate from Propylene Oxide and CO2.
Authors: Tharun Jose , Mathai George , Kathalikkattil Amal Cherian , Roshan Roshith , Won Yong‐Sun , Cho Sung June , Chang Jong‐San , Park Dae‐Won
Published: July 2015

Cycloaddition of propylene oxide (I) with CO2 (II) is accomplished under moderate reaction conditions using a zinc containing highly porous zeolitic imidazolate framework (ZIF‐90) as catalyst.
ChemInform Abstract: Selected Methodologies Convenient for the Synthesis of N,5‐Diaryloxazole‐2‐amine Pharmacophore.
Authors: Lintnerova Lucia , Kovacikova Lucia , Hanquet Gilles , Bohac Andrej
Published: July 2015

Four synthetic methodologies for the synthesis of N,5‐diaryloxazole‐2‐amines, strong pharmacophores found in 775 biologically active compounds, are discussed.
ChemInform Abstract: Application of the Tf2O/2‐Chloropyridine Couple in the Synthesis of Novel 4,5‐Unsubstituted N‐Carbamoyl‐2,3‐dihydroisoxazoles.
Authors: Zaborsky Ondrej , Soral Michal , Fischer Robert
Published: July 2015

A novel and mild method for the dehydration of substrates (I) and (III) is presented.
ChemInform Abstract: Flow Synthesis of Ethyl Isocyanoacetate Enabling the Telescoped Synthesis of 1,2,4‐Triazoles and Pyrrolo‐[1,2‐c]pyrimidines.
Authors: Baumann Marcus , Rodriguez Garcia Antonio M. , Baxendale Ian R.
Published: July 2015

The dehydration of N‐formylglycine (I) with triphosgene in a continuous flow reactor leads to a stream of ethyl isocyanoacetate, which reacts with in situ generated diazonium salts to afford desired 1,2,4‐triazoles.
ChemInform Abstract: Organocatalytic Oxa‐Diels—Alder Reaction of α,β‐Unsaturated Ketones under Non‐Classical Conditions.
Authors: Mojzesova Melinda , Meciarova Maria , Marti Roger , Sebesta Radovan
Published: July 2015

Pyranones are formed under several conditions in the presence of pyrrolidine‐derived organocatalysts.
ChemInform Abstract: Environmental Friendly Synthesis of Bis‐perfluoropyridine and Pyrimidine in Water.
Authors: Ranjbar‐Karimi Reza , Khaje‐Khezri Aliyeh
Published: July 2015

The title compounds are easily and efficiently obtained by reaction of pentafluoropyridine (I) or tetrafluoropyrimidine (VIII) with mono and bidentate N‐nucleophiles using water as green solvent.
ChemInform Abstract: Cu‐Catalyzed Oxidative Povarov Reactions Between N‐Alkyl N‐Methylanilines and Saturated Oxa‐ and Thiacycles.
Authors: Kawade Rahul Kisan , Huple Deepak B. , Lin Rong‐Jing , Liu Rai‐Shung
Published: July 2015

The reactions use neither [4π] nor [2π] motifs as initial reagents.
ChemInform Abstract: Regioselective Synthesis of 2‐Acylquinazolines and 3H‐1,4‐Benzodiazepin‐3‐ones by a Ugi 4CC/Staudinger/Aza‐Wittig Sequence.
Authors: Zhong Ying , Zhang Hao , Ding Ming‐Wu
Published: July 2015

Ugi reaction products (V) react with PPh3 via sequential Staudinger and intramolecular aza‐Wittig reaction to 2‐acylquinazolines and/or 1,4‐benzodiazepin‐3‐ones depending on steric and electronic effects of the R2‐group.
ChemInform Abstract: Cu(II)‐Catalyzed Domino Reaction of 2‐Halobenzamide and Arylmethanamine to Construct 2‐Aryl Quinazolinone.
Authors: Hu Ben‐Quan , Wang Li‐Xia , Xiang Jun‐Feng , Yang Luo , Tang Ya‐Lin
Published: July 2015

The reaction tolerates a range of aryl and hetarylmethanamines and delivers the products in moderate to high yields.
ChemInform Abstract: A Short and Highly Convergent Approach for the Synthesis of Rutaecarpine Derivatives.
Authors: Subba Reddy B. V. , Anji Babu R. , Jagan Mohan Reddy B. , Sridhar B. , Ramalinga Murthy T. , Pranathi P. , Kalivendi Shasi V. , Prabhakar Rao T.
Published: July 2015

Quinazolinoisoquinolines and benzimidazocarbolines are simply and conveniently synthesized by the condensation of anthranilamide or phenylenediamine derivatives, resp., with chloroaldehydes (I).
ChemInform Abstract: Gold‐Catalyzed Formation of Pyrrolo‐ and Indolo‐oxazin‐1‐one Derivatives: The Key Structure of Some Marine Natural Products.
Authors: Taskaya Sultan , Menges Nurettin , Balci Metin
Published: July 2015

3,4‐Dihydropyrrolo‐ and indolo‐oxazin‐1‐one derivatives are efficiently obtained by cyclization reactions of corresponding N‐propargylpyrrole and ‐indolecarboxylic acids, respectively.
ChemInform Abstract: TBAI‐Catalyzed Oxidative Cross‐Coupling of Phenols and 2‐Aminoacetophenones.
Authors: Xu Wei , Nachtsheim Boris J.
Published: July 2015

Various α‐phenoxylated 2‐aminoacetophenones such as (III) and (V) are obtained by iodide‐catalyzed intermolecular cross‐coupling of α‐aminoacetophenones with phenols.
ChemInform Abstract: Highly Selective Hydrothiolation of Unsaturated Organosilicon Compounds Catalyzed by Scandium(III) Triflate.
Authors: Kucinski Krzysztof , Pawluc Piotr , Marciniec Bogdan , Hreczycho Grzegorz
Published: July 2015

The hydrothiolation of allylsilanes with aromatic and aliphatic thiols proceeds under mild conditions to give the Markovnikov regioisomer as main product.
ChemInform Abstract: Ricinodols A—G: New Tetracyclic Triterpenoids as 11β‐HSD1 Inhibitors from Ricinodendron heudelotii.
Authors: Yu Jin‐Hai , Shen Yu , Wu Yan , Leng Ying , Zhang Hua , Yue Jian‐Min
Published: July 2015

All ricidinols exhibit an inhibitory effect on human and mouse 11β‐HSD1 with ricinodol E (V) showing the strongest effect.
ChemInform Abstract: Pd‐Catalyzed Directed ortho‐C—H Alkenylation of Phenylalanine Derivatives.
Authors: Garcia‐Rubia Alfonso , Laga Eduardo , Cativiela Carlos , Urriolabeitia Esteban P. , Gomez‐Arrayas Ramon , Carretero Juan C.
Published: July 2015

The reaction proceeds under exclusive formation of the E isomers and can also be applied in the synthesis of norephedrin derivatives (XIV).
ChemInform Abstract: Normal and Abnormal N‐heterocyclic Carbene Ligands: Similarities and Differences of Mesoionic C‐donor Complexes
Authors: Albrecht Martin
Published: July 2015

Review: 182 refs.
ChemInform Abstract: A Survey of Recent Synthetic Applications of 2,3‐Dideoxy‐hex‐2‐enopyranosides
Authors: Gomez Ana M. , Lobo Fernando , Miranda Silvia , Lopez J. Cristobal
Published: July 2015

Review: 171 refs.
ChemInform Abstract: Shelf‐Stable Electrophilic Reagents for Trifluoromethylthiolation
Authors: Shao Xinxin , Xu Chunfa , Lu Long , Shen Qilong
Published: July 2015

Review: 71 refs.
ChemInform Abstract: Dienals Derived from Pyridinium Salts and Their Subsequent Application in Natural Product Synthesis
Authors: Nolsoee Jens M. J. , Aursnes Marius , Tungen Joern E. , Hansen Trond V.
Published: July 2015

Review: [51 refs.
ChemInform Abstract: Bioactive Fused Heterocycles: Nucleoside Analogues with an Additional Ring
Authors: Jahnz‐Wechmann Zofia , Framski Grzegorz , Januszczyk Piotr , Boryski Jerzy
Published: July 2015

Review: 89 refs.
ChemInform Abstract: The Chemistry and Biological Activity of Heterocycle‐Fused Quinolinone Derivatives: A Review
Authors: Shiro Tomoya , Fukaya Takayuki , Tobe Masanori
Published: July 2015

Review: [49 refs.
ChemInform Abstract: Benzenediol Lactones: A Class of Fungal Metabolites with Diverse Structural Features and Biological Activities
Authors: Shen Weiyun , Mao Hongqiang , Huang Qian , Dong Jinyan
Published: July 2015

Review: 308 refs.
ChemInform Abstract: Benzoxazoles and Oxazolopyridines in Medicinal Chemistry Studies
Authors: Demmer Charles S. , Bunch Lennart
Published: July 2015

Review: 45 refs.
ChemInform Abstract: Recent Advances Bioactive 1,2,4‐Triazole‐3‐thiones
Authors: Kuecuekguezel S. Gueniz , Cikla‐Suezguen Pelin
Published: July 2015

Review: 148 refs.
ChemInform Abstract: Bioactive Thiazole and Benzothiazole Derivatives
Authors: Rouf Abdul , Tanyeli Cihangir
Published: July 2015

Review: [90 refs.
ChemInform Abstract: Advances and Challenges of Sodium Ion Batteries as Post Lithium Ion Batteries
Authors: Sawicki Monica , Shaw Leon L.
Published: July 2015

Review: emphasis on progress in anode and cathode materials; 165 refs.
ChemInform Abstract: The Non‐innocent Role of Cerium Oxide in Heterogeneous Catalysis: A Theoretical Perspective
Authors: Ganduglia‐Pirovano M. Veronica
Published: July 2015

Review: 125 refs.
ChemInform Abstract: Relative Stability of cis‐ and trans‐Hydrindanones
Authors: Tori Motoo
Published: July 2015

Review: 17 refs.
Combined heat and mass transfer of third‐grade nanofluids over a convectively‐heated stretching permeable surface
Authors: Khan Waqar A. , Culham J. Richard , Makinde O. Daniel
Published: July 2015

The buoyancy‐induced flows of third‐grade nanofluids are investigated along a vertical permeable stretching sheet, and a numerical solution is obtained for the combined heat and mass transfer during convective cooling of the stretching sheet, subject to partial slip and convective solutal boundary conditions. The Cauchy stress tensor for the fluids of grade three and Buongiorno model for the nanofluids are used in the governing equations. The model is capable of investigating the flow, heat, and mass characteristics of third‐grade nanofluids along the stretching sheet. The partial differential equations are converted into ordinary nonlinear differential equations and are solved using a second‐order numerical technique which includes a finite difference scheme and shooting method. The effects of the buoyancy, third‐grade, viscoelastic, partial slip, convective heat and mass transfer, and nanofluid parameters on the dimensionless velocity, temperature, concentration, skin friction, and heat and mass transfer rates are reported. The present results of skin friction and heat and mass transfer rates are compared with published data, and are found to be in close agreement.
Is Heart Rate Variability Related to Season of Birth?
Authors: Huang Wei‐Lieh , Hwang Be‐Tau , Lai Chun‐Ting , Li Jia‐Yi , Kuo Terry B.J. , Yang Cheryl C.H.
Published: July 2015

Background

Season of birth (SOB) has been found to be related to cardiovascular mortality, but the mechanisms are unclear. It is suggested that birth in winter is a protective factor for the circulatory system, and this should be able to be observed using heart rate variability (HRV) measurements. The phenomenon may have a sex difference and is likely to be modulated by climatic factors. This study focused on this problem and investigates healthy school‐age children to minimize confounding factors.

Hypothesis

Birth in winter is protective to cardiovascular system via autonomic modulation. There is a gender difference in the relationship between SOB and autonomic activity. Climatic factors are the cause of SOB effects on autonomic system.

Methods

A total of 381 healthy school‐age children were recruited for this study. Their HRV profiles were measured once and climatic information related to their month of birth was gathered. The HRV profiles of the 2 sexes and 4 seasons of birth were compared. Correlation and regression analysis were performed to clarify the relationship between climatic factors and the HRV results.

Results

Boys born in winter have higher high‐frequency power (HF) but a lower ratio of low‐frequency power to high‐frequency power (LF/HF) than do males born in other seasons. This result is not found for girls. Age and the temperature of the SOB are predictive factors for HF among boys. The humidity of SOB is a predictive factor for normalized low‐frequency power (LF%) and LF/HF among girls.

Conclusions

Season of birth is related to both parasympathetic and sympathetic activity among school‐age children, especially boys. Temperature and humidity are potential causes of this SOB phenomenon.
Rationale, Design, and Baseline Characteristics of the EPICOR Asia Study (Long‐tErm follow‐uP of antithrombotic management patterns In Acute CORonary Syndrome patients in Asia)
Authors: Huo Yong , Lee Stephen W.‐L. , Sawhney Jitendra P. S. , Kim Hyo‐Soo , Krittayaphong Rungroj , Nhan Vo T. , Alonso‐Garcia Angeles , Han Ya Ling , Ge Junbo , Chin Chee Tang , Ong Tiong K. , Jan Stephen , Itoh Yohji , Vega Ana Maria , Pocock Stuart
Published: July 2015

Background

In‐hospital and postdischarge mortality for acute coronary syndromes (ACS) vary across Asia and remain generally poorer than globally. The relationship between real‐life antithrombotic management patterns (AMPs) and ACS‐related outcomes in Asia is unclear.

Methods

EPICOR Asia (Long‐tErm follow‐uP of antithrombotic management patterns In acute CORonary syndrome patients in Asia) (NCT01361386) is a prospective, multinational, observational study of patients discharged after hospitalization for an ACS, with 2‐year follow‐up. The aim is to describe short‐ and long‐term (up to 2 years post–index event) AMPs in patients hospitalized for ACS and to record clinical outcomes, healthcare resource use, and self‐reported health status. Pre‐ and in‐hospital management, AMPs, and associated outcomes, with particular focus on ischemic and bleeding events, will be recorded during the 2‐year follow up.

Results

Between June 2011 and May 2012, 13 005 patients were enrolled. From these, 12 922 patients surviving an ACS (6616 with STEMI, 2570 with NSTEMI, and 3736 with UA) were eligible for inclusion from 219 hospitals across 8 countries and regions in Asia: China (n = 8214), Hong Kong (n = 177), India (n = 2468), Malaysia (n = 100), Singapore (n = 93), South Korea (n = 705), Thailand (n = 957), and Vietnam (n = 208).

Conclusions

EPICOR Asia will provide information regarding clinical management and AMPs for ACS patients in Asia. Impact of AMPs on clinical outcomes, healthcare resource use, and self‐reported health status both during hospitalization and up to 2 years after discharge will also be described.
Novel Triazolopyrimidine‐Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases
Authors: Nettekoven Matthias , Adam Jean‐Michel , Bendels Stefanie , Bissantz Catarina , Fingerle Jürgen , Grether Uwe , Grüner Sabine , Guba Wolfgang , Kimbara Atsushi , Ottaviani Giorgio , Püllmann Bernd , Rogers‐Evans Mark , Röver Stephan , Rothenhäusler Benno , Schmitt Sebastien , Schuler Franz , Schulz‐Gasch Tanja , Ullmer Christoph
Published: July 2015

The cannabinoid receptor 2 (CB2) system is described to modulate various pathological conditions, including inflammation and fibrosis. A series of new heterocyclic small‐molecule CB2 receptor agonists were identified from a high‐throughput screen. Lead optimization gave access to novel, highly potent, and selective (over CB1) triazolopyrimidine derivatives. A preliminary structure–activity relationship was established, and physicochemical properties in this compound class were significantly improved toward better solubility, lipophilicity, and microsomal stability. An optimized triazolopyrimidine derivative, (3S)‐1‐[5‐tert‐butyl‐3‐[(1‐cyclopropyltetrazol‐5‐yl)methyl]triazolo[4,5‐d]pyrimidin‐7‐yl]pyrrolidin‐3‐ol (39), was tested in a kidney ischemia–reperfusion model, in which it showed efficacy at a dose of 10 mg kg−1 (p.o.). A significant depletion of the three measured kidney markers indicated a protective role of CB2 receptor activation toward inflammatory kidney damage. Compound 39 was also protective in a model of renal fibrosis. Oral treatment with 39 at 3 mg kg−1 per day significantly decreased the amount of fibrosis by ∼40 % which was induced by unilateral ureter obstruction.
Long‐term sustained disease control in patients with mantle cell lymphoma with or without active disease after treatment with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning
Authors: Vaughn Jennifer E. , Sorror Mohamed L. , Storer Barry E. , Chauncey Thomas R. , Pulsipher Michael A. , Maziarz Richard T. , Maris Michael B. , Hari Parameswaran , Laport Ginna G. , Franke Georg N. , Agura Edward D. , Langston Amelia A. , Rezvani Andrew R. , Storb Rainer , Sandmaier Brenda M. , Maloney David G.
Published: July 2015

BACKGROUND

Previously, early results were reported for allogeneic hematopoietic cell transplantation (HCT) after nonmyeloablative conditioning with 2 Gy of total body irradiation with or without fludarabine and/or rituximab in 33 patients with mantle cell lymphoma (MCL).

METHODS

This study examined the outcomes of 70 patients with MCL and included extended follow‐up (median, 10 years) for the 33 initial patients. Grafts were obtained from human leukocyte antigen (HLA)–matched, related donors (47%), unrelated donors (41%), and HLA antigen–mismatched donors (11%).

RESULTS

The 5‐year incidence of nonrelapse mortality was 28%. The relapse rate was 26%. The 5‐year rates of overall survival (OS) and progression‐free survival (PFS) were 55% and 46%, respectively. The 10‐year rates of OS and PFS were 44% and 41%, respectively. Eighty percent of surviving patients were off immunosuppression at the last follow‐up. The presence of relapsed or refractory disease at the time of HCT predicted a higher rate of relapse (hazard ratio [HR], 2.94; P = .05). Despite this, OS rates at 5 (51% vs 58%) and 10 years (43% vs 45%) were comparable between those with relapsed/refractory disease and those undergoing transplantation with partial or complete remission. A high‐risk cytomegalovirus (CMV) status was the only independent predictor of worse OS (HR, 2.32; P = .02). A high‐risk CMV status and a low CD3 dose predicted PFS (HR, 2.22; P = .03).

CONCLUSIONS

Nonmyeloablative allogeneic HCT provides a long‐term survival benefit for patients with relapsed MCL, including those with refractory disease or multiple relapses. Cancer 2015;121:3709–3716. © 2015 American Cancer Society.
Utilization of workflow management system for virtual machine instance management on cloud
Authors: Kim Huioon , Chun Kyungwon , Kim Hyounggyu , Chung Youngjoo
Published: July 2015

The concept of virtualization is one of the most important technologies to construct a cloud service, and especially hardware virtualization is indispensable for infrastructure as a service (IaaS) where the cloud offering, infrastructure, is usually provided as a pool of virtual machine (VM) instances. For that reason, many public IaaS clouds like Amazon Web Service and private cloud toolkits such as Eucalyptus and OpenStack provide users with methods for managing VM instances via APIs, command‐line tools, web services, and so on. These are, however, not easy to use or customize for the average end users, especially for those in scientific research areas who just want to perform their work on a cloud and do not need to know the underlying technologies that much. Utilizing workflow management systems (WfMSs) in managing VMs on a cloud can alleviate these difficulties. Users only need to describe parameters needed for VMs and enact the workflow on a workflow enactment engine using user‐friendly interfaces. We propose a management scheme for VM instances on a cloud with the WfMS in this paper. We present a preliminary study on integrating cloud and WfMS focusing on management of VM instances and show an early implementation for a proof of concept with detailed explanations and possible usage scenarios. Copyright © 2015 John Wiley & Sons, Ltd.
Engineering Transition‐Metal‐Coated Tungsten Carbides for Efficient and Selective Electrochemical Reduction of CO2 to Methane
Authors: Wannakao Sippakorn , Artrith Nongnuch , Limtrakul Jumras , Kolpak Alexie M.
Published: July 2015

The design of catalysts for CO2 reduction is challenging because of the fundamental relationships between the binding energies of the reaction intermediates. Metal carbides have shown promise for transcending these relationships and enabling low‐cost alternatives. Herein, we show that directional bonding arising from the mixed covalent/metallic character plays a critical role in governing the surface chemistry. This behavior can be described by consideration of individual d‐band components. We use this model to predict efficient catalysts based on tungsten carbide with a sub‐monolayer of iron adatoms. Our approach can be used to predict site‐preference and binding‐energy trends for complex catalyst surfaces.
Upgrading Lignocellulosic Products to Drop‐In Biofuels via Dehydrogenative Cross‐Coupling and Hydrodeoxygenation Sequence
Authors: Sreekumar Sanil , Balakrishnan Madhesan , Goulas Konstantinos , Gunbas Gorkem , Gokhale Amit A. , Louie Lin , Grippo Adam , Scown Corinne D. , Bell Alexis T. , Toste F. Dean
Published: July 2015

Life‐cycle analysis (LCA) allows the scientific community to identify the sources of greenhouse gas (GHG) emissions of novel routes to produce renewable fuels. Herein, we integrate LCA into our investigations of a new route to produce drop‐in diesel/jet fuel by combining furfural, obtained from the catalytic dehydration of lignocellulosic pentose sugars, with alcohols that can be derived from a variety of bio‐ or petroleum‐based feedstocks. As a key innovation, we developed recyclable transition‐metal‐free hydrotalcite catalysts to promote the dehydrogenative cross‐coupling reaction of furfural and alcohols to give high molecular weight adducts via a transfer hydrogenation–aldol condensation pathway. Subsequent hydrodeoxygenation of adducts over Pt/NbOPO4 yields alkanes. Implemented in a Brazilian sugarcane biorefinery such a process could result in a 53–79 % reduction in life‐cycle GHG emissions relative to conventional petroleum fuels and provide a sustainable source of low carbon diesel/jet fuel.
Tunable Blue–Red Emission and Energy‐Transfer Properties of Mg3(PO4)2:­Eu2+,­Mn2+ Phosphors
Authors: Zhang Zheng , Tang Wanjun
Published: July 2015

A series of Eu2+‐doped and Eu2+/Mn2+‐codoped Mg3(PO4)2 phosphors were synthesized by the combustion‐assisted synthesis method. Under UV excitation, Mg3(PO4)2:Eu2+ presents a broad emission band, which can be decomposed into two symmetrical bands centered at λ = 427 and 467 nm, owing to the substitution of two kinds of Mg2+ sites by Eu2+ ions. In Mg3(PO4)2:Eu2+,Mn2+ phosphors, the excitation spectra monitored at the red emission of the Mn2+ ions is similar to that monitored at the blue emission of the Eu2+ ions, which illustrates the possibility of energy transfer from the Eu2+ ions to the Mn2+ ions. The variations of the emission spectra and decay lifetimes further demonstrate the existence of energy transfer from the Eu2+ ions to the Mn2+ ions under UV excitation. The energy‐transfer mechanism is dominated by electric dipole–dipole interactions, which can be validated by the agreement of the critical distances obtained from the concentration‐quenching (9.69 Å) and spectrum‐overlap methods (8.04 Å). The 4T1 → 6A1 emission band of the Mn2+ ions in Mg3(PO4)2:0.04Eu2+,yMn2+ shows a redshift as a function of the Mn2+ concentration (y), which has been discussed in relation to the exchange interactions between Mn2+–Mn2+ pairs.
Biomimetic Autocatalytic Synthesis of Organized Silica Hybrids
Authors: Licsandru Erol , Petit Eddy , Moldovan Simona , Ersen Ovidiu , Barboiu Mihail
Published: July 2015

Biogenic formation of silica is a fundamental process occurring under mild conditions. Here we report autocatalytic generation of silica hybrid materials. Self‐organized siloxanes containing imidazole self‐catalytic groups can be transformed to hybrid silica by using mild biomimetic conditions similar to those under which primitive organisms make silica.