bluuebunny/crossref_metadata_2025 huggingface dataset:
Phase II Study of AZD4547 in Patients With Tumors Harboring Aberrations in the FGFR Pathway: Results From the NCI-MATCH Trial (EAY131) Subprotocol W
Authors: Chae Young K. , Hong Fangxin , Vaklavas Christos , Cheng Heather H. , Hammerman Peter , Mitchell Edith P. , Zwiebel James A. , Ivy S. Percy , Gray Robert J. , Li Shuli , McShane Lisa M. , Rubinstein Larry V. , Patton David , Williams P. Mickey , Hamilton Stanley R. , Mansfield Aaron , Conley Barbara A. , Arteaga Carlos L. , Harris Lyndsay N. , O’Dwyer Peter J. , Chen Alice P. , Flaherty Keith T.
Published: May 2020

PURPOSE

NCI-MATCH is a nationwide, histology-agnostic, signal-finding, molecular profile–driven trial for patients with refractory cancers, lymphomas, or myelomas. Patients with tumors harboring actionable aberration(s) in fibroblast growth factor receptor ( FGFR) 1-3 were treated with AZD4547, an oral FGFR1-3 inhibitor.

METHODS

Patients’ tumors were screened by next-generation sequencing for predefined FGFR amplification, activating mutations, or fusions. Patients were treated with AZD4547, 80 mg orally twice daily until progression of disease or drug intolerance. A response rate of 16% was considered promising.

RESULTS

Between July 2016 and June 2017, 70 patients were assigned and 48 received protocol therapy and are eligible for analysis. Patients’ tumors harbored FGFR1 or FGFR2 amplification (n = 20), FGFR2 or FGFR3 single-nucleotide variants (n = 19), or FGFR1 or FGFR3 fusions (n = 9). The most common primary tumors were breast (33.3%), urothelial (12.5%), and cervical cancer (10.4%).Grade 3 adverse events were consistent with those described in previous clinical trials. Confirmed partial responses were seen in 8% (90% CI, 3% to 18%) and were observed only in patients whose tumors harbored FGFR1-3 point mutations or fusions. Stable disease was observed in 37.5% (90% CI, 25.8% to 50.4%). The median progression-free survival (PFS) was 3.4 months, and the 6-month PFS rate was 15% (90% CI, 8% to 31%). For patients with tumors harboring FGFR fusions, the response rate was 22% (90% CI, 4.1% to 55%), and 6-month PFS rate was 56% (90% CI, 31% to 100%).

CONCLUSION

Preliminary signals of activity appeared to be limited to cancers harboring FGFR activating mutations and fusions, although AZD4547 did not meet the primary end point. Different FGFR somatic alterations may confer different levels of signaling potency and/or oncogene dependence.
Impact of Standardized Edmonton Symptom Assessment System Use on Emergency Department Visits and Hospitalization: Results of a Population-Based Retrospective Matched Cohort Analysis
Authors: Barbera Lisa , Sutradhar Rinku , Seow Hsien , Earle Craig C. , Howell Doris , Mittmann Nicole , Li Qing , Thiruchelvam Deva
Published: May 2020

PURPOSE:

The Edmonton Symptom Assessment System (ESAS) is a validated instrument whose use has been standardized in the Ontario cancer system to measure symptoms among ambulatory patients with cancer. The objective was to examine the effect of ESAS exposure on visits to the emergency department (ED) and hospitalizations.

METHODS:

This was a retrospective matched cohort study conducted in Ontario, Canada. The study included patients ≥ 18 years of age diagnosed with cancer between 2007 and 2015. Patients were considered exposed if they were screened with ESAS at least once during the study period, and their first ESAS screening date was defined as the index date. Each exposed patient was matched randomly to a patient with cancer without ESAS assessment using a combination of hard matching (birth year ± 2 years, cancer diagnosis date ± 1 year, cancer type, and sex) and propensity score matching (14 variables, including cancer stage, treatments received, and comorbidities). A multivariable Andersen-Gill recurrent event model was used to evaluate the effect of ESAS on the rate of health care use.

RESULTS:

The analysis included 128,893 matched pairs that were well balanced on baseline measures. After adjusting for other variables, patients with ESAS had lower rates of both ED visits (relative rate [RR], 0.92; 95% CI, 0.91 to 0.93) and hospitalizations (RR, 0.86; 95% CI, 0.85 to 0.87) compared with patients without ESAS.

CONCLUSION:

ESAS exposure is independently associated with decreased rates of ED visits and hospitalizations. This provides real-world evidence of one potential positive impact of standardized symptom assessment in cancer care.
Question Prompt List to Support Patient-Provider Communication in the Use of the 21-Gene Recurrence Test: Feasibility, Acceptability, and Outcomes
Authors: Jayasekera Jinani , Vadaparampil Susan T. , Eggly Susan , Street Richard L. , Foster Moore Tanina , Isaacs Claudine , Han Hyo S. , Augusto Bianca , Garcia Jennifer , Lopez Katherine , O’Neill Suzanne C.
Published: May 2020

PURPOSE:

The 21-gene recurrence score (RS) assay is used to guide breast cancer treatment decisions but can be poorly understood by patients. We examined the effects of a question prompt list (QPL) on knowledge, distress, and decisional conflict related to genomic testing and treatment in early-stage breast cancer.

METHODS:

We describe the feasibility and acceptability of the QPL and the impact of the QPL on knowledge, distress, and decisional conflict before and after the receipt of the QPL (MEND 2, N = 65). We also compared distress and decisional conflict between women who received the QPL (MEND 2, N = 65) and a comparable group of women who did not receive the QPL who participated in an earlier observational study within the same clinics (MEND 1, N = 136).

RESULTS:

MEND 2 participants indicated high acceptability and feasibility using the QPL. Knowledge increased post-QPL ( P < .01) but did not decrease distress. Decisional conflict was lower among women in MEND 2 compared with those in MEND 1 ( P < .01), with no statistically significant differences in distress.

CONCLUSION:

The findings suggest that the QPL is feasible, acceptable, can improve knowledge and decrease decisional conflict in the large group of women deciding treatment while integrating RS test results.
Racism and the Political Economy of COVID-19: Will We Continue to Resurrect the Past?
Authors: Bailey Zinzi D. , Moon J. Robin
Published: May 2020

COVID-19 is not spreading over a level playing field; structural racism is embedded within the fabric of American culture, infrastructure investments, and public policy and fundamentally drives inequities. The same racism that has driven the systematic dismantling of the American social safety net has also created the policy recipe for American structural vulnerability to the impacts of this and other pandemics. The Bronx provides an important case study for investigating the historical roots of structural inequities showcased by this pandemic; current lived experiences of Bronx residents are rooted in the racialized dismantling of New York City's public infrastructure and systematic disinvestment. The story of the Bronx is repeating itself, only this time with a novel virus. To address the root causes of inequities in cases and deaths due to COVID-19, we need to focus not just on restarting the economy but also on reimagining the economy, divesting of systems rooted in racism, and the devaluation of Black and Brown lives.
Going the Extra Mile? How Provider Network Design Increases Consumer Travel Distance, Particularly for Rural Consumers
Authors: Haeder Simon F. , Weimer David L. , Mukamel Dana B.
Published: May 2020

Context: The practical accessibility to medical care facilitated by health insurance plans depends not just on the number of providers within their networks but also on distances consumers must travel to reach the providers. Long travel distances inconvenience almost all consumers and may substantially reduce choice and access to providers for some.

Methods: The authors assess mean and median travel distances to cardiac surgeons and pediatricians for participants in (1) plans offered through Covered California, (2) comparable commercial plans, and (3) unrestricted open-network plans. The authors repeat the analysis for higher-quality providers.

Findings: The authors find that in all areas, but especially in rural areas, Covered California plan subscribers must travel longer than subscribers in the comparable commercial plan; subscribers to either plan must travel substantially longer than consumers in open networks. Analysis of access to higher-quality providers show somewhat larger travel distances. Differences between ACA and commercial plans are generally substantively small.

Conclusions: While network design adds travel distance for all consumers, this may be particularly challenging for transportation-disadvantaged populations. As distance is relevant to both health outcomes and the cost of obtaining care, this analysis provides the basis for more appropriate measures of network adequacy than those currently in use.
Carbon footprint of fertilizer imports to the East African Bloc and policy recommendations for decarbonization
Authors: Kabiri Stella
Published: May 2020

Background: Almost all nitrogenous (N) fertilizers are fixed on an enormous scale using the Haber-Bosch ammonia synthesis process via a reaction of Nitrogen with hydrogen in the presence of a catalyst. This process is a leading global polluter, emitting 830 megatons of CO2 to the atmosphere annually. On the other hand, the global transport sector emits 7.5 gigatons of CO2 yet the fraction of emissions from freight transportation of N fertilizers from exporting countries to the East African (EA) Bloc is not known. This study examined the carbon footprint from freight transportation of N fertilizers. The findings are useful in the regions’ nationally determined contributions (NDCs) as per the Paris Agreement of December 2015 regarding downsizing emissions from the transport sector.

Methods: The study area included five EA Community (EAC) countries namely, Kenya, Uganda, Tanzania, Rwanda and Burundi. Statistics of fertilizers were obtained from https://africafertilizer.org/. The carbon footprint calculator (CFC) for fertilizer production (obtained from https://www.fertilizerseurope.com/), certified by the Carbon Trust Standard, was used.

Results: Over 93% of fertilizers imported to the EA Bloc are N fertilizers, leaving a carbon footprint of 4.9 megatons CO2-eq. Of these emissions, 1.1 megatons CO2-eq were contributed by imports from Saudi Arabia and 0.8 megatons CO2-eq from China. The ‘dirtiest’ of N fertilizers that accounted for the highest carbon footprint on the EA bloc were urea ammonium nitrate, calcium nitrate, nitrophosphates and ammonium sulphate.

Conclusions: Every metric ton of N imported results in a carbon footprint of 4.5 metric tons CO2-eq. The Ammonia production process of exporting countries, freight distance, choice and number of N fertilizers imported are significant determinants of greenhouse gas emissions to East Africa’s NDCs. To reach net-zero emissions the EA community needs to invest in new processes, circular economy and decarbonization pathways.
Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town
Authors: Hadebe Sabelo , Chengalroyen Melissa , Guler Reto , Nakedi Kehilwe , Koch Anastasia , Makatsa Mohau , Shey Muki , Parihar Suraj P. , Bryson Bryan , Marakalala Mohlopheni J. , Ndlovu Hlumani
Published: May 2020

Tuberculosis (TB), caused by the highly infectious Mycobacterium tuberculosis, remains a leading cause of death worldwide, with an estimated 1.6 million associated deaths reported in 2017. In South Africa, an estimated 322,000 (range 230,000-428,000) people were infected with TB in 2017, and a quarter of them lost their lives due to the disease. Bacille Calmette-Guérin (BCG) remains the only effective vaccine against disseminated TB, but its inability to confer complete protection against pulmonary TB in adolescents and adults calls for an urgent need to develop new and better vaccines. There is also a need to identify markers of disease protection and develop novel drugs. It is within this backdrop that we convened a nanosymposium at the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town to commemorate World TB Day and showcase recent findings generated by early career scientists in the institute. The speakers spoke on four broad topics: identification of novel drug targets, development of host-directed drug therapies, transmission of TB and immunology of TB/HIV co-infections.
Model of sickle kick pencak silat training based on exercise media in students pencak silat athletes
Authors: Amrullah Ramdani , Dlis Firmansyah , Hernawan Hernawan
Published: May 2020

Introduction. Techniques kick is most often used in competition and in the game self-defense more than 90% points scored by the kick competition that kicks effectivenessdepending on various factors, such as the maximum strength of the muscles involved in the level of development of strength, coordination neoromuscular, the linear velocity and the angle of the ankle when kicking leg and improve coordination between agonists and antagonists. develop a model exercise kick sickle-based media practice, because the model through the medium of exercise is a model of long-term and continuous change constantly, because this type of training will develop with regard to the development of athletes in accordance with the specifications of the branch sport, and System and method of exercise is getting day also thanks to the support of increasingly sophisticated equipment, facilities and infrastructure that is more modern.Objective of the study. This study aims to determine whether the basic Technicalskills learning model based media workout sickle kick effectively improve the skills and abilities of the sickle kick pencak silat sport student athletes.Research methods. Studies that use mixed methods research approach that combines qualitative and quantitative methods.Research Quantitative used to find the effectiveness of the True-Experimental research design shaped the pretest-posttest control group design.Research result. Initial tests ability sicklekick right and left of 6.944, 6.39. 65.22 skill being right, and left 71.26. after being given treatment ability right sicklekick 8.70 and 8.04 left. Skills right 62.48, 68.66 to the left.Conclusion.Based on the results of data from field trials and discussions can be concluded that this type of training with exercise effective media to enhance the capabilities and skills of the sickle kick sports pencak silat students.
Eating in isolation
Authors: Medlin Sophie
Published: May 2020

How does the lockdown affect behaviours? Dietitian Sophie Medlin reveals the ingredients for healthy and long-lasting wellbeing
Learning without boundaries: a world of webinars
Authors: Hylton Preetee
Published: May 2020

When COVID-19 disrupted all our lives, the Dental Nursing Academy was one of many organisations to embrace the digital platform as a way to continue its support for students. Dental nurse tutor Preetee Hylton explains…
Vortex dynamics and applications to gaseous optical elements
Authors: Kaganovich D. , Hafizi B. , Johnson L. A. , Gordon D. F.
Published: May 2020

Experimental studies of the optical properties of compressible,
viscous, and rapidly rotating gas flows (vortices) are presented. Gas
vortices can function as optical elements such as lenses or
waveguides. The optical properties are determined from direct
interferometric phase measurements and beam propagation analysis.
Output beams are analyzed in terms of Zernike polynomials for a range
of gas flow parameters, including choked flow. The absolute radial gas
density distribution is measured, and a technique for adjusting it is
demonstrated.
FODMAP urriko dieta eta haien erabilgarritasuna hesteko gaixotasunen maneiuan
Authors: Perez-Junkera Gesala , Lasa Arrate , Miranda Jonatan , Navarro Virginia , Simón Edurne , Larretxi Idoia , Martinez Olaia , Bustamante Marian , Txurruka Itziar , Vázquez-Polo Maialen
Published: May 2020

FODMAPak, modu naturalean esnekietan eta landare jatorriko zenbait elikagaitan aurki daitezkeen konposatuak, zenbait heste-gaixotasunetako sintomekin erlazionatu dira. Kate laburreko karbohidrato hartzigarri hauek zuntzaren antzeko efektuak eragiten dituzte, ur-atxikipena eragiten dute eta koloneko mikrobiotak hartzitzen dituzte, kate laburreko gantz azidoak eta gasak sortuz. Azken urteetan egin diren ikerketetan ikusi da FODMAP-kontsumoak beherakoa eta flatulentzia moduko sintomak eragiten dituela heste-funtzioaren aztoratzea duten gaixotasunetan, heste narritakorraren sindromean, hesteetako hanturazko gaixotasunean eta zeliakian esaterako. Horregatik, FODMAP urriko dieta eraginkorra dela ikusi da gaixotasun horien maneiuan, baina dietaren ezarpena zaila da. FODMAPen iturri diren elikagai asko murriztearen ondorioz, dieta desorekatu eta gabezia nutrizionalak ager daitezke, eta beraz, dietaren maneiu egokirako dietista-nutrizionista baten kontrola ezinbestekoa da. Nahiz eta dieta epe laburrean heste-sintomak murrizteko eraginkorra izan, epe luzera dituen ondorioak jakiteko ikerketa gehiagoren beharra dago, dieta oso murriztailea izan baitaiteke.
Automated Measurements of Muscle Mass Using Deep Learning Can Predict Clinical Outcomes in Patients With Liver Disease
Authors: Wang Nicholas C. , Zhang Peng , Tapper Elliot B. , Saini Sameer , Wang Stewart C. , Su Grace L.
Published: May 2020

INTRODUCTION:

There is increasing recognition of the central role of muscle mass in predicting clinical outcomes in patients with liver disease. Muscle size can be extracted from computed tomography (CT) scans, but clinical implementation will require increased automation. We hypothesize that we can achieve this by using artificial intelligence.

METHODS:

Using deep convolutional neural networks, we trained an algorithm on the Reference Analytic Morphomics Population (n = 5,268) and validated the automated methodology in an external cohort of adult kidney donors with a noncontrast CT scan (n = 1,655). To test the clinical usefulness, we examined its ability to predict clinical outcomes in a prospectively followed cohort of patients with clinically diagnosed cirrhosis (n = 254).

RESULTS:

Between the manual and automated methodologies, we found excellent inter-rater agreement with an intraclass correlation coefficient of 0.957 (confidence interval 0.953–0.961, P < 0.0001) in the adult kidney donor cohort. The calculated dice similarity coefficient was 0.932 ± 0.042, suggesting excellent spatial overlap between manual and automated methodologies. To assess the clinical usefulness, we examined its ability to predict clinical outcomes in a cirrhosis cohort and found that automated psoas muscle index was independently associated with mortality after adjusting for age, gender, and child's classification (P < 0.001).

DISCUSSION:

We demonstrated that deep learning techniques can allow for automation of muscle measurements on clinical CT scans in a diseased cohort. These automated psoas size measurements were predictive of mortality in patients with cirrhosis showing proof of principal that this methodology may allow for wider implementation in the clinical arena.
Isolation of phosphate-solubilizing bacteria from subtropical soils with different fertilization histories
Authors: Matter Juliana Maria , Sampaio Silvio César , Rosa Danielle Medina , Remor Marcelo Bevilacqua , Model Kathleen Jeniffer , Sbizzaro Mariana
Published: May 2020

Phosphorus is one of the most abundant chemical elements but has a low bioavailability index. Therefore, microrganisms play a fundamental role in providing insoluble phosphorus to plants. The objective of this study was to evaluate the capacity of bacteria to solubilize inorganic phosphates in soils with different fertilization histories. Soil and rhizosphere samples were collected from a Red Distroferric Latosol, including a control without mineral or organic fertilizer (C), treatment with mineral fertilizer (MF) according to the needs of each crop, and treatment with organic fertilizer [300 m3 ha-1 of swine wastewater (SW)]. The medium containing calcium phytate presented more colony-forming units (CFU) for all fertilization histories, and growth in treatments C and MF was 50% higher than treatment with SW. CFU values in soils treated with SW were lower than those in the other treatments, and the diversity of insoluble phosphate-solubilizing bacteria (PSB) was higher in treatment C. These results indicate a negative relationship between phosphorus concentrations and the number of PSB.
Physico-chemical characteristics and productivity of tomato plants in function of nitrogen sources and doses
Authors: Assunção Natália Silva , Silva Natalia Oliveira , Fernandes Flávio Lemes , Aquino Leonardo Angelo de , Fernandes Maria Elisa de Sena
Published: May 2020

The objective of this study was to evaluate the effect of nitrogen sources and rates on the physicochemical characteristics and yield of tomato plants. Forty hybrids were cultivated at 100 and 400 kg ha-1 of N, combined with four sources (urea, ammonium sulfate, ammonium nitrate and calcium), plus a treatment without N application in a randomized complete block design four replicates. Size, stem diameter, number of leaves, SPAD (Soil Plant Analysis Development), leaf nitrogen, number of fruits / plants, fruit firmness, bark thickness and average fruit size, ° BRIX, pH, calcium, potassium and sodium in fruits. There was an increase in SPAD index, Brix and longitudinal diameter of fruits as a function of the N dose. The use of ammonium nitrate and calcium provided stronger fruits. Urea and ammonium nitrate provided the highest pH value in tomato fruits. The application of the 100 kg ha-1 dose of N resulted in the highest potassium content in fruits. The highest productivity was obtained with the application of sources containing ammonium and the lowest in the control treatment. Sources and doses of nitrogen fertilizers influenced growth, productivity and parameters related to tomato quality.
Elderly health: professional training and performance in primary health care
Authors: Silva Maria Nauside Pessoa da , Lago Eliana Campelo , Nery Inez Sampaio , Almeida Camila Aparecida Pinheiro Landim , Tapety Fabrício Ibiapina , Maia Aíka Barros Barbosa , Silva Erisonval Saraiva da
Published: May 2020

To identify the influences of the professional training process for action in the Family Health Strategy (FHS) related to the health of the elderly man. Exploratory descriptive research, carried out with 20 professionals, from a Brazilian Northeast municipality from October to December 2014. The data collection was performed through a questionnaire, following the statements were processed in the software IRaMuTeQ, analyzed by the Descending Hierarchical Classification. Three classes emerged: Influences of the professional training process on elderly health care; Health care for the elderly; Actions developed in the family health strategy in the implementation of the national policy of comprehensive health care for the elderly. The findings suggest improved knowledge, lack of resources and medical specialties, evidenced the complexity of the actions developed by health professionals.
Growth and macronutrient absorption in ‘Sabará’ jabuticaba genotypes cultivated in nutrient solution
Authors: Ramos Martha Cristina Pereira , Rufini José Carlos Moraes , Campos Adriano Gonçalves de , Campos Matheus Pena , Guedes Mayara Neves Santos , Souza Janaina Canaan Rezende de
Published: May 2020

The knowledge about growth and nutrient accumulation can help improve fertilizer efficiency in the production of jabuticaba seedlings, which is still carried out in an empirical way. This study aimed at determining the growth and macronutrient uptake in ‘Sabará’ jabuticaba genotypes grown in nutrient solution. The experiment was carried out in a completely randomized design in split plots, with four replications. In the main plots three jabuticaba genotypes (J001, J005 and J012) were cultivated in nutrient solution and six evaluation periods (at 60, 120, 180, 240, 300 and 360 days) in the sub-plots were evaluated. Plant height, root length, stem diameter, leaf area index and dry matter (root, stem and leaves) in each period were evaluated. The accumulation of macronutrients in different plant organs was determined, as well as the accumulation of nutrients as a function of time adjusted to the linear model. The results showed that the cultivation in nutrient solution was efficient in the production of Sabará jabuticabeira seedlings. There was no difference in macronutrient growth and absorption among jabuticaba genotypes grown in nutrient solution. ‘Sabará’ jabuticaba plants accumulated (in mg plant-1) 559 of N, 45 of P, 443 of K, 363 of Ca, 59 of Mg and 82 of S. The distribution of macronutrient accumulations in jabuticaba showed the following order: leaves > stem > roots.
Bibliometric analysis of scientific research about sexuality and dementia in the elderly
Authors: Moreira Wanderson Carneiro , De Carvalho Ana Raquel Batista , Amorim Fernanda Cláudia Miranda , Lago Eliana Campêlo , Nóbrega Maria do Perpétuo S. S.
Published: May 2020

Map global scientific research on sexuality and dementia in the elderly to understand the focus and the growth of the area during the past decades. An exploratory study, descriptive and bibliometric with academic works on the database ISI Web of Knowledge/Web of ScienceTM. The following descriptors were used: “elder*”, “dementia*” and “sexuality*” in the time-based scratch between 1945 and 2018. The data analysis was performed with the aid of the software HistCiteTM. After applied the filters of refinement, there were identified 79 articles, published in 45 different journals indexed in the database in reference, written by 157 authors linked to 96 research institutions located in 19 countries. To achieve these articles there were used 2,312 references with an average of approximately 32 references per article. The international scientific production about sexuality and dementia in the elderly is scarce, and highlights the need for more specific studies on the theme and its potential for exploitation in future studies.
Stabilometric changes due to exposure to firearm noise in the Brazilian Army
Authors: Bernardo Luciana Dias , Scheeren Eduardo Mendonça , Marson Runer Augusto , Neves Eduardo Borba
Published: May 2020

Success in precision activities such as shooting depends on the subtle control of body motion. To analyze the influence on stabilometric signal responses for the motor task of aiming a pistol with different cognitive demands and levels of exposure to high sound pressure in Brazilian Army personnel. This cross-sectional analytical study used stabilometry to quantify the behavior of the body during motor, cognitive, and auditory tasks. Twenty-five volunteers recruited to participate in the study completed a questionnaire, underwent anthropometric evaluation and cinemetry, and scored the perceived difficulty during exposure to a sound pressure of 132 dB while using protective equipment. A significant increase in the displacement (p=0,02), anteroposterior amplitude (p=0,01), anteroposterior velocity (p=0,01), and the perceived difficulty scale (p=0,03) between Situation 1 (aiming without other cognitive action or environmental noise) and Situation 3 (shooting noise and progressive counting) was confirmed. number of shots heard). Correlation between the perceived difficulty scale and the variables of displacement (p=0,01), anteroposterior amplitude (p=0,01), area (p=0,006) and anteroposterior mean frequency (p=0,01) were observed. The accuracy of aiming events correlated with the median lateral median frequency (p=0,02). Stabilometric signals demonstrated increased total displacement, anteroposterior amplitude, and anteroposterior velocity in the presence of high sound pressure levels. These results indicate the need for future studies to investigate the underlying mechanisms of possible vestibular damage induced by noise.
Use of molecular markers SSR and SCAR for identification of olive accessions
Authors: Val Aurinete Daienn Borges do , Breves Sâmera de Souza , Cançado Geraldo Magela de Almeida , Ferreira Juliano Lino , Pasqual Moacir
Published: May 2020

Morphological and agronomical describers are traditionally used in plant characterization. However, the usage of these describers have some limitations such as susceptibility to abiotic and biotic stress and environmental factors. Furthermore, the describers are not stable over time and many can only be evaluated during the adult phase of the plants, which requires time and physical space. Molecular markers offer numerous advantages compared to the conventional alternatives based on phenotype: they are stable and detectable in all vegetable tissues, and are independent of the environment and development phase. One of the main advantages of the use of molecular markers is the time reduction in the identification of genetic diversity among the studied subjects, as the genotypes may even be described for the seed or seedling phase. Many countries have already adopted molecular markers to identify olive cultivars more accurately. The aim of this study was to evaluate the genetic identity of eight olive accessions supposedly belonging to cultivar Arbequina by using microsatellite (SSR) and Sequence Characterized Amplified Region (SCAR) markers. One accession corresponding to the cultivar was also incorporated into the analysis as a reference genotype. The molecular marker data were analyzed on the software GENALEX6. The markers generated an accumulated PI and PE of 1.26 x 10-6 and 0.949, respectively. The results supported the hypothesis that all accessions belong to the cultivar Arbequina, and the markers can therefore be applied to other varieties of olive species.
Agronomic parameters and morpho-agronomic characteristics of genetically modified maize hybrids compared to conventional maize hybrids
Authors: Ramos Leandro Nogueira , Souza Nara Oliveira Silva , Vilela Michelle Souza
Published: May 2020

The objectives were to study the behavior of fifteen pre-commercial upland maize hybrids, analyze their agronomic performance regarding grain yield, and evaluate productivity components, as well as morpho-agronomic characteristics, in the Midwest Region of Brazil. Two experiments were conducted in the municipalities of Formosa-GO and Planaltina-DF, 2016/17 crop year. Both consisted of five pre-commercial maize hybrid platforms (HPA252, HPB262, HPB621, HPB646, and HPD354). Each platform consisted of three different versions: conventional, transgenic with a Bt gene that expresses the protein Cry1F, and transgenic with two Bt genes that express the proteins Cry1F and Cry1AB. The experiment was randomized blocks with four replications. The experimental plot was four lines five meters long considering the two central lines as useful. The lines were spaced 0.75 meters apart, and the final density was five plants per linear meter. To estimate grain yield, the plots were harvested, and the weight was extrapolated to kg.ha-1. The moisture was standardized at 14%. Data were submitted to analysis of variance, and the means were compared by Tukey test at 5% probability using the Sisvar software. Grain yield between treatments ranged from 8,381 to 12,908 kg.ha-1, and the average yield was 11,234 kg.ha-1. The parameters evaluated were divided into two groups. The first group contained parameters determining grain yield: grain depth, thousand grains weight, number of rows of grains, number of grains per row, and grain yield. The second group contained morpho-agronomic parameters that directly interfere with resistance to lodging and plant breaking: plant height, ear insertion height, and mean stem diameter. There was no direct effect of the transgenes on the evaluated hybrids since the classification of productivity was not divided into conventional and transgenic classes. It is suggested that the HPA252YH, HP621H and HP646H versions be discarded because grain yield performance was unsatisfactory compared to their respective conventional and transgenic counterparts. The parameters GD and W1000 are more effective for grain yield estimation than NR and NG. It was observed for HP621H that, in addition to a lower grain yield, there was a significant reduction in stem diameter, indicating a possible reduction in lodging tolerance and/or plant breaking when exposed to adverse climatic conditions such as windstorms. For the HPD354H version, the release of the transgenic counterpart HPD354YH is preferentially indicated since the H version had a significant reduction in stem diameter and a possible greater tolerance to lodging and/or plant breaking under the same conditions.
Influence of storage temperatures and storage time of dry leaves on patchouli [Pogostemon cablin (Blanco) Benth.] essential oil
Authors: Arrigoni-Blank Maria de Fatima , Santos Priscilla Santana , Blank Arie Fitzgerald , Brito Fabiany de Andrade , Andrade Thiago Matos , Nizio Daniela Aparecida de Castro , Alves Péricles Barreto
Published: May 2020

Patchouli [Pogostemon cablin (Blanco) Benth.] is a plant of the family Lamiaceae, widely used as an essential oil in the cosmetics and perfumery industry. This study aimed to evaluate the influence of storage time and temperature of dry leaves on the patchouli essential oil content and chemical composition. The experiment was performed in a completely randomized design in a 6x2x2 factorial scheme, testing storage time (0, 1, 2, 4, 8, and 16 weeks) and temperature (28°C and 33°C) of dry leaves of two patchouli genotypes (POG-015 and POG-021).  The variables essential oil content and chemical composition, and the identification of fungus during storage were evaluated. Results showed that the storage significantly influenced the essential oil content. Patchoulol was identified as the major compound in both genotypes, ranging from 55.05% to 68.77% (POG-15) and from 52.83% to 64.06% (POG-021). Based on the results of patchoulol, dry leaves of both genotypes (POG-015 and POG-021) can be stored for up to eight weeks at 28- 33°C without altering the essential oil quality.
Brazilian cerrado species: wood characteristics
Authors: Faria Mayara Cristina Gomes de , Silva Neto Carlos de Melo e , Lima Pedro Augusto Fonseca , Chagas Matheus Peres , Tomazello Filho Mario , Sette Junior Carlos Roberto
Published: May 2020

The characterization of wood anatomy and proprieties can provide subsidies for rational use of tree species. Enables, oftentimes, the definition of technological potential of wood - and wood products -   through the assessment of quality information and also allows it´s correct identification, contributing to the timber production chain.  The objective of this study was to contribute to the knowledge about wood properties of the Cerrado biome (Brazilian savanna) species trough the anatomical characterization and determination of density profile. Twenty trees species belonging to thirteen families occurring in Pirenópolis, Goiás and Brasília, Federal District, Brazil, was selected and radial samples were removed from the tree trunks at the DBH (1.30 m) in a non-destructive way using an incremental probe and a motorized extractor. The qualitative and quantitative anatomical parameters of vessels and fibers and the wood density were determined in the collected samples. Species presented fibers with mean values between 900.5 and 2052.9 µm for the length; 18.1 and 27.7 µm for the diameter; and 4.4 to 9.4 µm for the wall thickness. The species presented a variation in the vessel dimensions from 29.2 to 155.6 µm for the diameter; 17.7 to 32.5% for occupied area; and 2.6 to 165 to vessels.mm-2. The apparent density presented mean values between 0.36 and 1.21 g cm-3. The specie that presented the highest variation of wood density was A. fraxinifolium. According to the radial profiles two patterns of increasing and stable variation in the apparent density of the pith to bark were defined as a function of the wood anatomical characteristics.
Glyphosate-resistant soybeans yield in function of glyphosate salts, doses and stadium phenological
Authors: Rohr Lucas Alfonso , Cinelli Rafaela , Polito Rubens Antonio , Heck Tamara , Bispo Noryam Bervian , Nunes Anderson Luis
Published: May 2020

Given the importance of soybean to the global economy and as a food source, improving crop management techniques is integral to obtaining higher yields. As such, this study aimed to assess the yield of soybean cultivars as a function of different glyphosate salt formulations, doses and application times. Two field experiments were conducted simultaneously using a randomized block design and 3x4x2 factorial scheme, with three repetitions. Factor A consisted of three glyphosate formulations: isopropylamine salt (Roundup Original®), ammonium salt (Roundup WG®), and potassium salt (Zapp Qi®), factor B four application times: 0, 14, 28, 42 days after planting (DAP), and factor C two doses: the recommended dose of 720 grams of acid equivalent per hectare and twice that (1440 grams of acid equivalent per hectare). There was no difference between the glyphosate salts for the BMX Ativa RR® cultivar, but yields of BMX Apolo RR® submitted to ammonium salt were 28% higher than those recorded for the other salts studied. Glyphosate potassium salt resulted in lower soybean yields. Potassium salt application between 14 and 28 DAP caused greater toxicity in both the soybean cultivars analyzed.
Morphoagronomic characterization of Lantana camara L. germplasm
Authors: Nascimento Luís Fernando de Andrade , Blank Arie Fitzgerald , Sá Filho José Carlos Freitas de , Pereira Katily Luize Garcia , Nizio Daniela Aparecida de Castro , Arrigoni-Blank Maria de Fátima , Oliveira Alisson Marcel Souza de , Souza Vinícius Trindade de
Published: May 2020

The medicinal and aromatic species Lantana camara is a bush that receives a lot of interest regarding ornamental use. However, due to its condition of invasive plant in natural environments, it suffers constant eradication attempts, which causes genetic erosion of the species. To work around this problem, a sample of the genetic variability of L. camara was saved in the Active Germplasm Bank of medicinal and aromatic plants of the Federal University of Sergipe (UFS). This study aimed to evaluate morphoagronomically 22 accessions of L. camara, collected in 15 municipalities in the state of Sergipe. To carry out morphoagronomic characterization, morphological and agronomic traits were analyzed. Phenotypic variability among the accessions of the L. camara collection for all the analyzed morphological quantitative and agronomic characteristics was observed. The means ranged from 4.91 to 6.90 cm for leaf length; from 2.81 to 5.03 cm for leaf width; from 1.32 to 1.87 for the leaf length/width ratio; from 9.59 to 22.98 mm2 for leaf area; from 99.00 to 215.00 cm for crown diameter; from 85.67 to 214.33 for plant height; and from 1.08 to 2.43 cm for stem diameter. Most accessions presented erect form. The mean number of flowers per inflorescence varied from 12 to 38 flowers. For the agronomic traits, we observed that the dry mass ranged from 49.86 to 649.04 g.plant-1. The mean content of essential oil ranged from 0.13 to 0.26% and yield between 0.10 and 1.55 mL.plant-1. The most divergent phenotypic accessions were LAC-001 (São Cristóvão) and LAC-038 (Moita Bonita) and the ones with the lowest divergence were LAC-004 (Itaporanga D'ajuda) and LAC-019 (Siriri). Thus, it was observed that the variables were efficient to differentiate the accessions and suggest the existence of genetic variability among them.
Evaluation of the comparative influence of magnesium sulfate single and combination with ritodrine hydrochloride in the prevention of preterm delivery
Authors: Shuifang Xu , Fengying Zhang , Yuhua He , Xiyun Lv , Jinfang Tian , YI Qi , Fengying Xu
Published: May 2020

This project was designed to explore the effects of ritodrine hydrochloride combined with magnesium sulfate in the prevention of preterm delivery of patients with threatened premature birth. 128 cases of threatened premature birth were randomly divided into two groups according to the number table method. The control group was treated with magnesium sulfate, while the study group was treated with ritodrine hydrochloride combined with magnesium sulfate. The d(p>0.05). ata was analyzed using SPSS 18.0 and was subjected to Chi-square and t test. The onset time and prolonged gestation time of the study group were shorter than those of the control group (p<0.05). There was no difference in the incidence of myocardial ischemia between the study group and the control group (p>0.05). The heart rate per minute of the study group was higher than that of the control group (p<0.05). There was no difference in blood pressure between the study group and the control group Nevertheless, the neurological function, pregnancy outcome and neonatal status of the group were better than those of the control group (p<0.05).
First epidemiological description of tegumentar and visceral Leishmaniasis in Patrocínio Municipality, Minas Gerais (2000-2017)
Authors: Nunes Débora Cristina de Oliveira Silva , Paulista Layla Gabrielle Silva , Ribeiro Samarah Borges Nunes , Nunes Ana Luiza Borges de Paula
Published: May 2020

Leishmaniasis is a disease that can affect visceral organs (visceral leishmaniasis; VL) or mucous membranes and skin, causing lesions of different forms and levels of severities (tegumentary leishmaniasis; TL). Like several others, leishmaniasis is a neglected disease, as the pharmaceutical industry seems to show little to no interest in developing new drugs targeting the disease. This study aims to trace the epidemiological profile of leishmaniasis in the Municipality of Patrocínio, State of Minas Gerais, over a period of time. Secondary data of reported cases from 2000 to 2017 were analyzed as provided by the Patrocinio Health Department. As no literature was found on the status of such a disease in Patrocinio, it is important to trace the epidemiological profile of leishmaniasis in the area. The findings pointed out that the disease affected predominantly male in the economically active population, mainly from the urban area, and that it had no relationship with professional activity. Twenty-two cases of leishmaniasis (15 of TL and 7 of VL) were reported, all of which were treated and cured. Five cases of TL and 1 case of VL were autochthonous, and confirmed cases of canine infection took place in 2011, 2016 and 2017.
Will novel coronavirus (Covid-19) pandemic impact agriculture, food security and animal sectors?
Authors: Seleiman Mahmoud F. , Selim Shaimaa , Alhammad Bushra Ahmed , Alharbi Basmah M. , Juliatti Fernando Cezar
Published: May 2020

The whole world is in a great danger due to the novel coronavirus (COVID-19) pandemic. In December 2019, the outbreak of COVID-19 took place in Wuhan, China and then rapidly spread all over the world. The current study provides potential expectations for the adverse impact of (COVID-19). The global infection affected globe on agricultural level such as agriculture, food supplies and animal production sectors. Till today, 29th April 2020, there is no vaccine available for treating novel coronavirus, consequently, the outbreak resulted in closing borders and reducing production following social distancing measures. This short communication illustrates the possible implications and expected outcomes of the outbreak of coronavirus (COVID-19) on agricultural, food security, integrated pest management (IPM), animal productivity; and it predicts, as well, the possible adverse impacts on the economy worldwide. Brazil has one of the most important tropical agriculture in the world, being a leader in soybean production in the world. This chain impacts others such as meat and eggs. The impact of COVID-19 will be positive, encouraging the country to consolidate its leadership in the world market, stimulating exports, the machinery, inputs and fertilizers market, as well as generating employment and income in the country.
Neologia, cognição e comunicação
Authors: Demai Fernanda Mello
Published: May 2020

Currículo Escolar em Educação Profissional Técnica de Nível Médio, nossa área-tema, é definido como ´o esquema teórico-metodológico que direciona o desenvolvimento de formações profissionais técnicas de nível médio, conforme as demandas sociais, que incluem as demandas produtivas e laborais´. Objetivamos discutir aspectos relacionados a neologia, cognição e comunicação relativos aos termos da área-tema, com a análise de textos brasileiros autênticos, escritos, de natureza legal, institucional e pedagógica, que compõem corpus produzido entre 2000 e 2016. Daremos ênfase à função neológica, que se refere à propriedade dos termos de materializarem linguisticamente novos conceitos, ligada à terminologização (a transposição do nível conceptual para o nível linguístico). A função neológica é evidenciada em composições sintagmáticas, conforme seu caráter de lexicalização inacabada, como em matriz curricular; perfil de competências; currículo por competências. A função neológica permite a criação de novos termos (neologia), no eixo sintagmático, como competência, com o qual criam-se outros termos, compostos: competências profissionais, competências gerais, competências laborais. Esses termos novos formados por composição no eixo horizontal da frase são denominados neologismos sintagmáticos, os quais são muito frequentes nas novas terminologias. A função neológica caracteriza também termos simples, formados por apenas um item lexical, a exemplo de função, que se constitui em neologismo semântico, pela atribuição de um novo significado a um significante já presente na língua – nesse caso, a novidade (ou neo) está no significado novo, não em uma forma ou composição novos. Utilizamos princípios das Teorias Sociocognitiva e Comunicativa da Terminologia, valorizando aspectos cognitivos e comunicativos dos termos, além da criatividade lexical.
INTERVENSI PEKERJA SOSIAL DALAM REUNIFIKASI EKS GANGGUAN JIWA DI BALAI REHABILITASI SOSIAL BINA KARYA DAN LARAS (BRSBKL) YOGYAKARTA
Authors: Alia Fahri , Abridinata Wibowo Tri Shandra , Sukendar Hendrik Basguni , Dina Ekmil Lana
Published: May 2020

Abstract            Factors of poverty, low education, divorce cause is often referenced as the brain's disease. There is a significant relationship between problems experienced by a person with his behavior. Because, often people who are experiencing problems are always included with changes in behavior that is not unusual. This behavioral change is then done through a behavioral approach to restore the behavior as it once was.       In this case as conducted by the Social Rehabilitation Bina Karya and Laras (BRSBKL) to ex mental disorders. Clients who initially are someone who lives in a normal society, then when experiencing problems change drastically all his behavior becomes angry, quiet, aloof, not confident or afraid. But after receiving behavioral assistance then the clients are slowly experiencing a significant development into a person who would open, independent living, courage, mutual cooperation or already able to activity daily living.But in the process, not all clients who experience exs psychiatric disorders can be predicted when they will be healthy again. This can be seen from the level of problems and the desire of the client to return to health. Therefore, the handling of psychological exs through a behavioral approach can not be ascertained when it will end.Keywords: Behavioral theory, Mental Disorders, Rehabilitation.