bluuebunny/crossref_metadata_2025 huggingface dataset:
At-Home Training With a Rhythmic Video Game for Improving Orofacial, Manual, and Gait Abilities in Parkinson’s Disease: A Pilot Study
Authors: Puyjarinet Frédéric , Bégel Valentin , Geny Christian , Driss Valérie , Cuartero Marie-Charlotte , De Cock Valérie Cochen , Pinto Serge , Dalla Bella Simone
Published: June 2022

Rhythm disorders are consistently reported in Parkinson’s disease (PD). They manifest across motor domains, such as in orofacial (oral diadochokinesis), manual (finger tapping), and gait tasks. It is still unclear, however, whether these disorders are domain- and task-specific, or result from impaired common mechanisms supporting rhythm processing (general dysrhythmia). We tested the possibility that an at-home intervention delivered via a rhythmic video game on tablet improves motor performance across motor domains in PD. Patients with PD (n = 12) played at home a rhythmic video game (Rhythm Workers) on tablet, in which they finger-tapped to the beat of music, for 6 weeks. A control group (n = 11) played an active non-rhythmic video game (Tetris). A third group (n = 10) did not receive any intervention. We measured rhythmic abilities in orofacial, manual and gait motor domains, as well as rhythm perception, before and after the intervention. Patients who performed the rhythmic training improved their orofacial and manual rhythmic performance. This beneficial effect was linked to improved rhythm perception only following the rhythmic training period. We did not observe any improvement in rhythmic abilities in the other two groups. In this pilot study, we demonstrated that at-home intervention with a rhythmic video game using finger tapping can have beneficial effects on motor performance across different motor domains (manual and orofacial). This finding provides evidence of a general dysrhythmia in PD and paves the way to technology-driven interventions aiming at alleviating rhythm-related motor deficits in PD.
Role of Transforming Growth Factor Beta in Peripheral Nerve Regeneration: Cellular and Molecular Mechanisms
Authors: Ye Zhiqian , Wei Junbin , Zhan Chaoning , Hou Jin
Published: June 2022

Peripheral nerve injury (PNI) is one of the most common concerns in trauma patients. Despite significant advances in repair surgeries, the outcome can still be unsatisfactory, resulting in morbidities such as loss of sensory or motor function and reduced quality of life. This highlights the need for more supportive strategies for nerve regrowth and adequate recovery. Multifunctional cytokine transforming growth factor-β (TGF-β) is essential for the development of the nervous system and is known for its neuroprotective functions. Accumulating evidence indicates its involvement in multiple cellular and molecular responses that are critical to peripheral nerve repair. Following PNI, TGF-β is released at the site of injury where it can initiate a series of phenotypic changes in Schwann cells (SCs), modulate immune cells, activate neuronal intrinsic growth capacity, and regulate blood nerve barrier (BNB) permeability, thus enhancing the regeneration of the nerves. Notably, TGF-β has already been applied experimentally in the treatment of PNI. These treatments with encouraging outcomes further demonstrate its regeneration-promoting capacity. Herein, we review the possible roles of TGF-β in peripheral nerve regeneration and discuss the underlying mechanisms, thus providing new cues for better treatment of PNI.
The Impact of Zinc Supplementation on Critically Ill Patients With Acute Kidney Injury: A Propensity Score Matching Analysis
Authors: Xia Wenkai , Li Chenyu , Zhao Danyang , Xu Lingyu , Kuang Meisi , Yao Xiajuan , Hu Hong
Published: June 2022

Background

Zinc is an essential trace element involved in multiple metabolic processes. Acute kidney injury (AKI) is associated with low plasma zinc, but outcomes with zinc supplementation in critically ill patients with AKI remain unknown. Our objective was to investigate the effectiveness of zinc supplementation in this patient population.

Methods

Critically ill patients with AKI were identified from the Medical Informative Mart for Intensive Care IV database. Prosperity score matching (PSM) was applied to match patients receiving zinc treatment to those without zinc treatment. The association between zinc sulfate use and in-hospital mortality and 30-day mortality, need for renal replacement therapy (RRT), and length of stay was determined by logistic regression and Cox proportional hazards modeling.

Results

A total of 9,811 AKI patients were included in the study. PSM yielded 222 pairs of patients who received zinc treatment and those who did not. Zinc supplementation was associated with reduced in-hospital mortality (HR = 0.48 (95% CI: 0.28, 0.83) P = 0.009) and 30-day mortality (HR = 0.51 (95% CI, 0.30, 0.86) P = 0.012). In the subgroup analysis, zinc use was associated with reduced in-hospital mortality in patients with stage 1 AKI and those with sepsis.

Conclusions

Zinc supplementation was associated with improved survival in critically ill patients with AKI. The supplementation was especially effective in those with stage 1 AKI and sepsis. These results need to be verified in randomized controlled trials.
The Transcultural Diabetes Nutrition Algorithm: A Middle Eastern Version
Authors: Hamdy Osama , Al Sifri Saud , Hassanein Mohamed , Al Dawish Mohammed , Al-Dahash Raed A. , Alawadi Fatheya , Jarrah Nadim , Ballout Hajar , Hegazi Refaat , Amin Ahmed , Mechanick Jeffrey I.
Published: June 2022

Diabetes prevalence is on the rise in the Middle East. In countries of the Gulf region—Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates—prevalence rates are among the highest in the world. Further, Egypt now ranks as one of the top 10 countries in the world for high number of people with diabetes. Medical nutrition therapy is key to optimal management of diabetes. Patient adherence to nutritional guidance depends on advice that is tailored to regional foods and cultural practices. In 2012, international experts created a transcultural Diabetes Nutrition Algorithm (tDNA) for broad applicability. The objective of this current project was to adapt the algorithm and supportive materials to the Middle East region. A Task Force of regional and global experts in the fields of diabetes, obesity, and metabolic disorders met to achieve consensus on Middle East-specific adaptations to the tDNA. Recommendations, position statements, figures, and tables are presented here, representing conclusions of the tDNA-Middle Eastern (tDNA-ME) Task Force. Educational materials can be used to help healthcare professionals optimize nutritional care for patients with type 2 diabetes. The tDNA-ME version provides evidence-based guidance on how to meet patients' nutritional needs while following customs of people living in the Middle Eastern region.
Nosocomial Infections During Extracorporeal Membrane Oxygenation in Pediatric Patients: A Multicenter Retrospective Study
Authors: Wang Chunle , Li Shuanglei , Wang Feng , Yang Jinfu , Yan Wei , Gao Xue , Wen Zhiqiang , Xiong Yaoyao
Published: June 2022

Objective

Extracorporeal membrane oxygenation (ECMO) is increasingly used in critically ill patients with respiratory and/or cardiac failure. This study aimed to investigate the epidemiology and risk factors of nosocomial infection (NI) in pediatric patients who underwent ECMO for respiratory and/or circulatory failure.

Methods

Medical records for patients that were administered underwent ECMO support at Xiangya Second Hospital of Central South University, The Sixth Medical Center of PLA General Hospital, and Children's Hospital Affiliation of Zhengzhou University, from September 2012 to December 2019 were retrospectively reviewed. Clinical data of the patients who developed NI were collected and analyzed. Univariate and multivariate logistic regressions were performed to identify the independent predictive factors of NI during ECMO.

Results

A total of 54 first episodes of NI were identified in the 190 patients on ECMO, including 32 cases of respiratory tract infections, 20 cases of bloodstream infections, and 2 cases of surgical site wound infections. Gram-negative pathogens were the dominant pathogens isolated, accounting for 92.6% of the NI. The incidence of ECMO-related NI was 47.6 cases per 1,000 ECMO days. In the univariate logistic regression, ECMO mode, ECMO duration, ICU duration, and peritoneal dialysis were associated with the development of NI in patients with ECMO support. However, in the multivariate analysis, only ECMO duration (OR = 2.46, 95%CI: 1.10, 5.51; P = 0.029), ICU duration (OR = 1.35, 95%CI: 1.05, 1.59; P = 0.017) and peritoneal dialysis (OR = 2.69, 95%CI: 1.08, 5.73; P = 0.031) were the independent predictive factors for NI during ECMO support.

Conclusion

This study identified the significant correlation between ECMO-related NI and ECMO duration, ICU duration, and peritoneal dialysis. Appropriate preventive measures are needed for hospitals to reduce the incidence of ECMO in pediatric patients.
Virtual Reality-Based Sensory Stimulation for Pediatric Disorders of Consciousness: A Pilot Study
Authors: Liang Piao , Xu Hong , Li Sinan , Ren Lei , Zhao Xiaoke
Published: June 2022

Objective

The purpose of this study was to determine whether virtual reality-based sensory stimulation has the ability to improve the level of consciousness in pediatric disorders of consciousness compared with general rehabilitation.

Methods

Thirty subjects were divided into a virtual reality (VR) group (n= 15) and a control group (n= 15). Subjects in the VR group received both general rehabilitation and exposure to VR videos; the control group received only general rehabilitation. The Glasgow Coma Scale (GCS), Coma Recovery Scale-Revised (CRS-R), and amplitude-integrated electroencephalogram (EEG) (aEEG) were used to measure the clinical behavioral response and neuroelectrophysiology before and after the treatment. The Glasgow Outcome Scale Extended Pediatric Revised (GOS-E Peds) was used to measure the social and personal functional ability after 3 months.

Results

After 2 weeks of treatment, the CRS-R and GCS improved in both groups. However, the VR group had better results than the control group in the CRS-R (p= 0.003) and GCS (p= 0.045). There were no significant differences on aEEG in the two groups after treatment. According to the GOS-E Peds, the improvement of social and personal functional ability had no significant differences in the two groups. Additionally, there were no obvious adverse reactions in the two group during the treatment.

Conclusions

This pilot study indicates potential benefit from the addition of VR to standard rehabilitation in pediatric disorders of consciousness. To further explore the efficacy of VR, a large-sample randomized controlled trial is warranted.
Cisplatin Promotes the Efficacy of Immune Checkpoint Inhibitor Therapy by Inducing Ferroptosis and Activating Neutrophils
Authors: Zhou Ziwei , Zhao Yiming , Chen Si , Cui Guohui , Fu Wenkui , Li Shouying , Lin Xiaorong , Hu Hai
Published: June 2022

The combination of immunotherapy with platinum-based chemotherapy has become the first-line treatment for patients with advanced non–small cell lung cancer (NSCLC) with negative driver gene mutations. However, finding an ideal chemotherapeutic regimen for immunotherapy and exploring the underlying mechanism have noticeably attracted clinicians’ attention. In this study, we found that cisplatin induced ferroptosis of tumor cells, followed by N1 neutrophil polarization in the tumor microenvironment, which in turn remodeled the “cold” tumor to a “hot” one through enhancing T-cell infiltration and Th1 differentiation. Based on the important role of tumor ferroptosis in the immune-promoting effect of cisplatin, we noticed that the combination of a ferroptosis activator showed a synergistic effect with chemoimmunotherapy of epidermal growth factor receptor (EGFR)-mutant NSCLC, which would be an effective strategy to overcome immunotherapy resistance in NSCLC patients harboring driver mutations.
Functional Characterization of Two Variants at the Intron 6—Exon 7 Boundary of the KCNQ2 Potassium Channel Gene Causing Distinct Epileptic Phenotypes
Authors: Mosca Ilaria , Rivolta Ilaria , Labalme Audrey , Ambrosino Paolo , Castellotti Barbara , Gellera Cinzia , Granata Tiziana , Freri Elena , Binda Anna , Lesca Gaetan , DiFrancesco Jacopo C. , Soldovieri Maria Virginia , Taglialatela Maurizio
Published: June 2022

Pathogenic variants in KCNQ2 encoding for Kv7.2 potassium channel subunits have been found in patients affected by widely diverging epileptic phenotypes, ranging from Self-Limiting Familial Neonatal Epilepsy (SLFNE) to severe Developmental and Epileptic Encephalopathy (DEE). Thus, understanding the pathogenic molecular mechanisms of KCNQ2 variants and their correlation with clinical phenotypes has a relevant impact on the clinical management of these patients. In the present study, the genetic, biochemical, and functional effects prompted by two variants, each found in a non-familial SLNE or a DEE patient but both affecting nucleotides at the KCNQ2 intron 6-exon 7 boundary, have been investigated to test whether and how they affected the splicing process and to clarify whether such mechanism might play a pathogenetic role in these patients. Analysis of KCNQ2 mRNA splicing in patient-derived lymphoblasts revealed that the SLNE-causing intronic variant (c.928-1G > C) impeded the use of the natural splice site, but lead to a 10-aa Kv7.2 in frame deletion (Kv7.2 p.G310Δ10); by contrast, the DEE-causing exonic variant (c.928G > A) only had subtle effects on the splicing process at this site, thus leading to the synthesis of a full-length subunit carrying the G310S missense variant (Kv7.2 p.G310S). Patch-clamp recordings in transiently-transfected CHO cells and primary neurons revealed that both variants fully impeded Kv7.2 channel function, and exerted strong dominant-negative effects when co-expressed with Kv7.2 and/or Kv7.3 subunits. Notably, Kv7.2 p.G310S, but not Kv7.2 p.G310Δ10, currents were recovered upon overexpression of the PIP2-synthesizing enzyme PIP5K, and/or CaM; moreover, currents from heteromeric Kv7.2/Kv7.3 channels incorporating either Kv7.2 mutant subunits were differentially regulated by changes in PIP2 availability, with Kv7.2/Kv7.2 G310S/Kv7.3 currents showing a greater sensitivity to PIP2 depletion when compared to those from Kv7.2/Kv7.2 G310Δ10/Kv7.3 channels. Altogether, these results suggest that the two variants investigated differentially affected the splicing process at the intron 6-exon 7 boundary, and led to the synthesis of Kv7.2 subunits showing a differential sensitivity to PIP2 and CaM regulation; more studies are needed to clarify how such different functional properties contribute to the widely-divergent clinical phenotypes.
Repositioning of Anti-Inflammatory Drugs for the Treatment of Cervical Cancer Sub-Types
Authors: Kori Medi , Arga Kazim Yalcin , Mardinoglu Adil , Turanli Beste
Published: June 2022

Cervical cancer is the fourth most commonly diagnosed cancer worldwide and, in almost all cases is caused by infection with highly oncogenic Human Papillomaviruses (HPVs). On the other hand, inflammation is one of the hallmarks of cancer research. Here, we focused on inflammatory proteins that classify cervical cancer patients by considering individual differences between cancer patients in contrast to conventional treatments. We repurposed anti-inflammatory drugs for therapy of HPV-16 and HPV-18 infected groups, separately. In this study, we employed systems biology approaches to unveil the diagnostic and treatment options from a precision medicine perspective by delineating differential inflammation-associated biomarkers associated with carcinogenesis for both subtypes. We performed a meta-analysis of cervical cancer-associated transcriptomic datasets considering subtype differences of samples and identified the differentially expressed genes (DEGs). Using gene signature reversal on HPV-16 and HPV-18, we performed both signature- and network-based drug reversal to identify anti-inflammatory drug candidates against inflammation-associated nodes. The anti-inflammatory drug candidates were evaluated using molecular docking to determine the potential of physical interactions between the anti-inflammatory drug and inflammation-associated nodes as drug targets. We proposed 4 novels anti-inflammatory drugs (AS-601245, betamethasone, narciclasin, and methylprednisolone) for the treatment of HPV-16, 3 novel drugs for the treatment of HPV-18 (daphnetin, phenylbutazone, and tiaprofenoic acid), and 5 novel drugs (aldosterone, BMS-345541, etodolac, hydrocortisone, and prednisolone) for the treatment of both subtypes. We proposed anti-inflammatory drug candidates that have the potential to be therapeutic agents for the prevention and/or treatment of cervical cancer.
Integrating Metabolomics and Network Analysis for Exploring the Mechanism Underlying the Antidepressant Activity of Paeoniflorin in Rats With CUMS-Induced Depression
Authors: Lei Chaofang , Chen Zhigang , Fan Lili , Xue Zhe , Chen Jianbei , Wang Xihong , Huang Zhen , Men Yinian , Yu Mingzhi , Liu Yueyun , Chen Jiaxu
Published: June 2022

Background: Paeoniflorin (PF) represents the major bioactive constituent of the traditional Chinese medicine plant Paeonia suffruticosa (Ranunculaceae), which has a long history as a folk medicine in Asian. Paeoniflorin, a bitter pinene monoterpene glycoside, has antidepressant effects, but its potential therapeutic mechanism has not been thoroughly explored.

Methods: Experimental depression in rats was established by the chronic unpredictable mild stress (CUMS) combined with orphan method, and the efficacy of paeoniflorin on depression was evaluated by the sucrose preference test and open field test. The antidepressant mechanism of paeoniflorin was investigated by metabolomic and network pharmacology. The relevant pathways of biomarkers highlighted in metabolomics were explored, and the possible targets of paeoniflorin in the treatment of depression were further revealed through network analysis. The binding activity of paeoniflorin to key targets was verified by molecular docking.

Results: Metabolomics showed that rats with CUMS-induced depression had urine metabolic disorders, which were reversed by paeoniflorin through the regulation of metabolic pathways. Metabolites that play a key role in the function of paeoniflorin include citric acid, thiamine monophosphate, gluconolactone, 5-hydroxyindoleacetic acid and stachyose. Key predicted targets are SLC6A4, TNF, IL6 and SLC6A3. An important metabolic pathway is the Citrate cycle (TCA cycle).

Conclusion: Network integrative analysis in this study showed that paeoniflorin could improve depressive-like symptoms in model rats with CUMS-induced depression and overall correct the disordered metabolic profile through multiple metabolic pathways.
Ultra High-Performance Supercritical Fluid Chromatography for the Quantitation of Diterpene Resin Acids in Norway Spruce Samples
Authors: Goels Thomas , Eichenauer Elisabeth , Langeder Julia , Aichner Georg F. , Mauser Gregor , Amtmann Luisa , Grienke Ulrike , Glasl Sabine
Published: June 2022

Picea abies (L.) H. Karst. (Pinaceae) is native to Northern, Central and Eastern Europe. The fast-growing tree reaches up to 50 m in height, has modest nutritional requirements and depends on sufficient water supply. The conifer, commonly called Norway spruce, produces exudates which are traditionally used to treat skin wounds in Northern European countries. Major bioactive constituents of the conifer oleoresin are diterpene resin acids (DRAs) of the abietane and the pimarane type. To assure consistent pharmaceutical quality of Norway spruce balm and commercial products thereof, an analytical method for the quantitation of DRAs is the prerequisite. However, high structural similarity among DRAs and their poor UV absorption makes chromatographic separation and detection challenging: Conventional liquid chromatography systems often fail to achieve sufficient separation, moreover, they are not sustainable. Gas chromatography on the other hand requires time-consuming derivatization prior to unacceptably long analyses (>60 min). These drawbacks prompted the development of the first validated supercritical fluid-based protocol for the separation and quantitation of eight DRAs, i.e., pimaric acid (1), sandaracopimaric acid (2), palustric acid (3), isopimaric acid (4), levopimaric acid (5), abietic acid (6), dehydroabietic acid (7), and neoabietic acid (8). By using an ultra high-performance supercritical fluid chromatography (UHPSFC) device hyphenated to a quadrupole mass detector, the DRAs were separated in less than 20 min on a Torus 2-Picolylamin (2-PIC) column (3.0 mm × 100 mm; 1.7 µm particle size) applying supercritical CO2 and ethanol as mobile phase. Regarding selectivity, accuracy (recovery rates: 87–108%), intermediate precision (between 6.6 and 11.1%), and linearity (R2 ≥ 0.99; linear between 0.75 μg/ml and 2.5 mg/ml), results were obtained in line with ICH guidelines. The lowest limit of detection (LOD) was at 0.75 μg/ml (7) and the lowest limit of quantitation (LOQ) at 2 μg/ml (8). As application examples, 22 Norway spruce balm samples and five commercial products were analyzed. The here presented protocol not only simplifies and shortens the analytical workflow, but also reduces the amount of organic solvent waste by about two thirds compared to conventional liquid chromatographic set-ups. These advantages qualify this fast and efficient method as an ideal tool for an environmentally friendly quality control of traditionally used wound-healing Norway spruce balm products.
Should Renal Inflammation Be Targeted While Treating Hypertension?
Authors: Chaudhari Sarika , Pham Grace S. , Brooks Calvin D. , Dinh Viet Q. , Young-Stubbs Cassandra M. , Shimoura Caroline G. , Mathis Keisa W.
Published: June 2022

Despite extensive research and a plethora of therapeutic options, hypertension continues to be a global burden. Understanding of the pathological roles of known and underexplored cellular and molecular pathways in the development and maintenance of hypertension is critical to advance the field. Immune system overactivation and inflammation in the kidneys are proposed alternative mechanisms of hypertension, and resistant hypertension. Consideration of the pathophysiology of hypertension in chronic inflammatory conditions such as autoimmune diseases, in which patients present with autoimmune-mediated kidney inflammation as well as hypertension, may reveal possible contributors and novel therapeutic targets. In this review, we 1) summarize current therapies used to control blood pressure and their known effects on inflammation; 2) provide evidence on the need to target renal inflammation, specifically, and especially when first-line and combinatory treatment efforts fail; and 3) discuss the efficacy of therapies used to treat autoimmune diseases with a hypertension/renal component. We aim to elucidate the potential of targeting renal inflammation in certain subsets of patients resistant to current therapies.
Brand Knowledge and Organizational Loyalty as Antecedents of Employee-Based Brand Equity: Mediating Role of Organizational Culture
Authors: Liu Xiaoming
Published: June 2022

This study tends to explore the impact of brand knowledge and organizational loyalty under the mediating role of organizational culture on employee-based brand equity (EBBE). For this purpose, employees of the hospitality sector were contacted to collect data through personally administrated questionnaires. Already established scales were used to devise instruments. Data were collected in two waves to minimize the common method bias. In the first wave, a total of 600 questionnaires were distributed, out of which 400 were received back, while in the second wave, remaining respondents were approached who have filled the survey in the first wave, and only 320 were received back, from which the partial and incomplete questionnaires were discarded, and at the end, 306 questionnaires were left. These final and completed responses were used for the data analysis and inferential purpose in this study. Collected data have been analyzed through Structural Equation Modeling by using Smart PLS 3 software. The assessment of measurement and structural model indicated a good model fit, and results indicate that EBBE is influenced by organizational loyalty and brand knowledge positively. Moreover, the mediating role of organizational culture has also been proved.
The Mediator CSR Plays the Effective Leadership Belief Role for Resource Dilemma Handling Leadership in Organizational Commitment During Sustainability Development
Authors: Chan Kuo-Hua , Lin Shang-Ping , Shih I-Tung
Published: June 2022

The authors aim to explore a better fitting leadership style that is designed for the sustainable era in believing and committing to work for cherishing resources and developing the organization toward a new sustainable direction. This study developed the questionnaire items of the Resource-Dilemma-Handling-Leadership (RDHL) scale, representing a new sustainable era's new leadership style, and then to compare it with the transformational leadership style in order to highlight the importance of RHDL for sustainable development. This study took companies, which have more than 100 employees in Taiwan as research samples. Those companies were selected because they were socially tagged as being operating continuously for more than 20 years and identifying themselves with the operational orientation of social responsibility as their business philosophy and core values for management. A total of 532 valid questionnaires were collected, with a 90.6% valid return rate, and tested with the SEM method. Consistent with the authors' inferences from the literature, the test results suggest that CSR plays the role of full mediator between RDHL and OC. CSR itself is like a sense of responsibility, giving employees a sense of mission, to complete meaningful sustainability-relevant tasks in the organization. RDHL, compared with TL, has a better prediction power on CSR and OC. Theoretically, this study implies that the impact of leadership of the organization on OC in the aspects of sustainable development should be going through the influence of the ELB system in the form of CSR to promote the organization's internal and external organizational CSR performance, with added internal strengthening power from OC. Practically, the new RDHL concepts brought up by this study include the training and enhancement of leadership skills based on the content of the scale items being explored. The new RDHL scale contains a comprehensive description of the spirit of the new sustainable era's leadership style. Also, the future applications of RDHL ideas in the form of human resource development should help the realization of the ideally sustainability behavioral patterns of leaders and employees in the organizations.
The Conjoint Family Drawing: A Tool to Explore About Family Relationships
Authors: Gennari Marialuisa , Tamanza Giancarlo
Published: June 2022

In this article we will present the Conjoint Family Drawing, a graphic-interactive tool developed to evaluate family relationships. This tool allows an analytical and clinical evaluation of families and their relationships while facilitating the understanding of the overall family functioning through a synthetic coding system which distinguishes families from each other. First of all, a presentation of the analytical coding system is provided; such system consists of a grid, formed by two distinct levels of observation: the analysis of the product, which, in turn focuses on two levels, the global-familiar one (given by the overall drawing) and the individual one (given the individual members’ drawings), and the analysis of the drawing process (what happens during the realization of the drawing), which is made up of the observations of family interactions at the individual and group level. Consistently with our objectives and the theoretical and methodological literature on family drawing in its various forms and ways of implementation, 10 indicators for product analysis and 9 indicators for process analysis have been identified. A sample of 117 Conjoint Family Drawings was analyzed in order to verify the coding system’s applicability and effectiveness. The sample was constituted according to a convenience (not probabilistic) criterion. Following, a computing system was developed to allow the investigation of the overall family functioning through three steps: (1) the analysis of the frequency distribution of each indicator, in order to verify the non-determinability rates and the distribution of the different answer options; (2) a two-step cluster analysis, to determine homogeneous groups of Conjoint Family Drawings and identify, within each cluster (and comparatively between the clusters), the indicators and answer modalities that mostly affect the clusters’ aggregation itself; (3) the development of a synthetic system to code the Conjoint Family Drawing, beginning with the indicators that define the typological profiles of the clusters obtained. The synthetic system was developed through a summative and logical-combinatorial method, merging the most discriminating and clinically significant coding items, that is, those that are best associable to specific ways of family functioning. Seven family types emerged from these analyses: families characterized by optimal functioning, families characterized by adequate functioning, families characterized by chaotic functioning, families characterized by fragile paternity, families characterized by separate functioning, families with multiproblematic functioning and residual families. The characteristics of these family types will be outlined in this article.
What Is the Weather Prediction Task Good for? A New Analysis of Learning Strategies Reveals How Young Adults Solve the Task
Authors: Bochud-Fragnière Emilie , Banta Lavenex Pamela , Lavenex Pierre
Published: June 2022

The Weather Prediction Task (WPT) was originally designed to assess probabilistic classification learning. Participants were believed to gradually acquire implicit knowledge about cue–outcome association probabilities and solve the task using a multicue strategy based on the combination of all cue–outcome probabilities. However, the cognitive processes engaged in the resolution of this task have not been firmly established, and despite conflicting results, the WPT is still commonly used to assess striatal or procedural learning capacities in various populations. Here, we tested young adults on a modified version of the WPT and performed novel analyses to decipher the learning strategies and cognitive processes that may support above chance performance. The majority of participants used a hierarchical strategy by assigning different weights to the different cues according to their level of predictability. They primarily based their responses on the presence or absence of highly predictive cues and considered less predictive cues secondarily. However, the influence of the less predictive cues was inconsistent with the use of a multicue strategy, since they did not affect choices when both highly predictive cues associated with opposite outcomes were present simultaneously. Our findings indicate that overall performance is inadequate to draw conclusions about the cognitive processes assessed by the WPT. Instead, detailed analyses of performance for the different patterns of cue–outcome associations are essential to determine the learning strategies used by participants to solve the task.
Iconic Mathematics: Math Designed to Suit the Mind
Authors: Kramer Peter
Published: June 2022

Mathematics is a struggle for many. To make it more accessible, behavioral and educational scientists are redesigning how it is taught. To a similar end, a few rogue mathematicians and computer scientists are doing something more radical: they are redesigning mathematics itself, improving its ergonomic features. Charles Peirce, an important contributor to ordinary symbolic logic, also introduced a rigorous but non-symbolic, graphical alternative to it that is easier to picture. In the spirit of this iconic logic, George Spencer-Brown founded iconic mathematics. Performing iconic arithmetic, algebra, and even trigonometry, resembles doing calculations on an abacus, which is still popular in education today, has aided humanity for millennia, helps even when it is merely imagined, and ameliorates severe disability in basic computation. Interestingly, whereas some intellectually disabled individuals excel in very complex numerical tasks, others of normal intelligence fail even in very simple ones. A comparison of their wider psychological profiles suggests that iconic mathematics ought to suit the very people traditional mathematics leaves behind.
Does Nice or Nasty Matter? The Intensity of Touch Modulates the Rubber Hand Illusion
Authors: Della Longa Letizia , Sacchetti Sofia , Farroni Teresa , McGlone Francis
Published: June 2022

Our sense of body ownership results from the ongoing integration of perceptual information coming from the different senses (i.e., multisensory integration). The Rubber Hand Illusion (RHI) has been extensively studied to investigate the malleability of body ownership through contrasting multisensory information. Indeed, during the RHI, stroking a visible rubber hand synchronously to participants’ hand hidden from sight generates the illusion of ownership of the rubber hand (embodiment) and the mis-location of participants’ hand as closer to the rubber hand (proprioceptive drift). It is well known that the RHI is optimally evoked by a pleasant stroking (affective) touch, but what of an unpleasant (painful) stroking touch – does hedonic valence matter? To this aim, participants repeated the RHI while receiving different types of touch: pleasant, painful, and neutral. Results showed, for the first time, that the subjective intensity of the tactile stimulation experienced across the different conditions modulates the strength of the proprioceptive drift. Notably, participants reported a stronger RHI (mis-placed body ownership) from stimulation rated as more intense and involving an interoceptive activation (pain and pleasantness vs. neutral). We propose that interoceptive information, regardless of the valence of the stimuli (positive or negative), are perceived as more intense and enhance, through the activation of the limbic system, multisensory integration. In the context of the RHI, this translates to a stronger illusion in terms of proprioceptive drift.
The Mediating Effect of Reassurance-Seeking Behavior on the Influence of Viral Anxiety and Depression on COVID-19 Obsession Among Medical Students
Authors: Kim Hyun Sub , Ahn Junseok , Lee Jukab , Hong Youjin , Kim Changnam , Park Jangho , Chung Seockhoon
Published: June 2022

Objectives

Healthcare workers experienced great psychological burden due to the continuation of the COVID-19 pandemic. During the pandemic, medical healthcare workers experienced greater instances of insomnia, anxiety, depression, somatization, and obsessive-compulsive symptoms than the general population. This study aimed to explore the association between viral anxiety and obsession with COVID-19 among medical students with reassurance-seeking behavior as a mediator.

Methods

In October 2021, an online survey was conducted among medical students at the University of Ulsan College of Medicine. The clinical characteristics of 162 participants and their responses to rating scales, including stress and anxiety to viral Epidemics-6 items (SAVE-6), Coronavirus Reassurance-Seeking Behaviors Scale (CRBS), Patient Health Questionnaire-9 items (PHQ-9), and Obsession with COVID-19 scale were collected.

Results

Medical students' obsession with COVID-19 was based on the PHQ-9 (β = 0.15, p = 0.01), SAVE-6 (β = 0.43, p < 0.001), and CRBS (β = 0.38, p < 0.001) scores (adjusted R2 = 0.49, F = 39.9, p < 0.001). Mediation analysis showed that medical students' viral anxiety and depression directly influenced their obsession with COVID-19, and their reassurance-seeking behavior partially mediated the effects of depression or viral anxiety on obsession with COVID-19.

Conclusions

Medical students' viral anxiety and depression may affect their obsession with COVID-19, and reassurance-seeking behaviors may mediate this. Therefore, medical students should adopt adaptive coping strategies to prevent high levels of viral anxiety and recurrent reassurance-seeking behavior.
Relationship Between Economic Loss and Anxiety During the Coronavirus Disease 2019 Pandemic: Moderating Effects of Knowledge, Gratitude, and Perceived Stress
Authors: Jang Hyerim , Park A-La , Lee Yu-Ri , Ryu Seunghyong , Lee Ju-Yeon , Kim Jae-Min , Kim Sung-Wan , Kang Young-Shin
Published: June 2022

Objectives

The prolonged coronavirus disease 2019 (COVID-19) pandemic has caused individuals to suffer economic losses, in particular due to the implementation of intensive quarantine policies. Economic loss can cause anxiety and has a negative psychological impact on individuals, worsening their mental health and satisfaction with life. We examined the protective and risk factors that can influence the relationship between economic loss and anxiety during the COVID-19 pandemic.

Methods

Panel data from 911 participants were collected in April and May 2020 and again 6 months later. We analyzed the relationship between economic loss and anxiety and investigated the moderating effects of knowledge about COVID-19, gratitude, and perceived stress. Moreover, we investigated whether there were any changes in moderating effects over time or in different demographic groups.

Results

In the early stages of the spread of COVID-19, gratitude (B = –0.0211, F = 4.8130, p < 0.05) and perceived stress (B = 0.0278, F = 9.3139, p < 0.01) had moderating effects on the relationship between economic loss and anxiety. However, after 6 months, only perceived stress had a significant moderating effect (B = 0.0265, F = 7.8734, p < 0.01).

Conclusion

In the early stages of COVID-19, lower levels of gratitude and higher perceived stress led to greater anxiety. In later stages of the prolonged pandemic, only perceived stress had a continued moderating effect on the relationship between economic loss and anxiety. This study suggests that psychological interventions to reduce perceived stress are needed to treat the possible adverse effects of the spread of infectious diseases on mental health.
Understanding Emergency Department Healthcare Professionals' Perspectives of Caring for Individuals in Suicidal Crisis: A Qualitative Study
Authors: Rheinberger Demee , Wang Jessica , McGillivray Lauren , Shand Fiona , Torok Michelle , Maple Myfanwy , Wayland Sarah
Published: June 2022

Help seekers regularly present to Emergency Departments (EDs) when in suicidal crisis for intervention to ensure their immediate safety, which may assist in reducing future attempts. The emergency health workforce have unique insights that can inform suicide prevention efforts during this critical junction in an individual's experience with suicide. This paper explores the treatment and care delivery experiences of 54 health professionals working in EDs within one of the LifeSpan suicide prevention trial sites in Australia. Data was collected via six focus groups and six interviews. Thematic analysis resulted in three themes: (1) physicality of the emergency department, (2) juggling it all–the bureaucracy, practicalities, and human approach to care, and (3) impact of care delivery on ED staff. Findings highlight the need for workplace training that incorporates responding to the uncertainty of suicidal crisis, to compliment the solution-focused medical model of care. Broader policy changes to the ED system are also considered to ensure better outcomes for health professionals and help-seekers alike.
Developmental Origins of Pregnancy-Related Morbidity and Mortality in Black U.S. Women
Authors: Lin Betty , Appleton Allison A.
Published: June 2022

In the US, Black women are at disproportionate risk for pregnancy-related morbidity and mortality (PRMM). Disparities in PRMM have been tied to elevated rates of obstetric cardiometabolic complications for Black women. Research seeking to elucidate the determinants of Black PRMM to date have focused predominantly on risk factors occurring during pregnancy (e.g., health risk behaviors, quantity and quality of prenatal care, provider behaviors, and attitudes). Meanwhile, other research investigating the developmental origins of health and disease (DOHaD) model indicates that the origins of adult cardiometabolic health can be traced back to stress exposures occurring during the intrauterine and early life periods. Despite the relevancy of this work to Black PRMM, the DOHaD model has never been applied to investigate the determinants of Black PRMM. We argue that the DOHaD model represents a compelling theoretical framework from which to conceptualize factors that drive racial disparities PRMM. Research and intervention working from a developmental origins orientation may help address this urgent public health crisis of Black PRMM.
Lower Subjective Socioeconomic Status Is Associated With Increased Risk of Reporting Negative Experiences on Social Media. Findings From the “LifeOnSoMe”-Study
Authors: Skogen Jens Christoffer , Bøe Tormod , Finserås Turi Reiten , Sivertsen Børge , Hella Randi Træland , Hjetland Gunnhild Johnsen
Published: June 2022

Objectives

To investigate the association between subjective socioeconomic status (SES) and a) frequency and daily duration of social media use, and b) self-reported negative experiences on social media platforms.

Methods

The present study is based on the cross-sectional school-based “LifeOnSoMe”-study (N = 3,415) recruiting high school students aged 16 years or more in Bergen, Norway. Subjective SES was the independent variable and measured by perceived family affluence. The dependent variables included self-reported amount of social media use, and eight different types of negative experiences on social media. Self-reported age, gender, country of birth and type study were used as covariates. Statistical analyses included multinomial logistic regression and negative binomial regression models.

Results

For amount of social media use, we only found relatively weak and inconsistent associations with SES. In contrast, the associations between SES and separate variables gauging negative experiences were robust in crude models as well as in models adjusted for age and gender. The number of different negative experiences were increased by 1.25 times for those with low and by 1.10 times for those with medium socioeconomic status, compared to those with high socioeconomic status in fully adjusted models. For composite measures of “negative acts and exclusion” and “unwanted attention from others,” the difference between low and high SES was equivalent to a small-to-moderate effect size even after adjustments for age, gender, country of birth, type of study and amount of social media use.

Conclusions

In the present study, we found consistent and strong support for an association between SES and negative experiences on social media even after adjustments for age, gender, country of birth, type of study, and amount of social media use. The potential link between SES and negative experiences on social media as reported in this study is likely to have a public health impact. As the reported findings are novel, they need to be replicated in forthcoming studies based on other study populations. Future research should also focus on other aspects of SES and negative experiences, as well as endeavor to investigate potential longitudinal associations.
Scaling Nurturing Care Interventions in the Health Sector: A Theory of Change Perspective
Authors: Rasheed Muneera A.
Published: June 2022

Nurturing care interventions postulated on strengthening caregiver-child relationships have proven to be effective for improving early childhood development outcomes in low- and middle-income countries. Hence, a scale-up of the interventions has been recommended with an emphasis on the health sector given the contact with families in the critical first 3 years of life. However, an effective scale-up of an integrated intervention through healthcare requires a theory of change approach elucidating pathways of sustainable change. From this viewpoint, I reflect on my experience of scaling the intervention in a private pediatric care setting. I realized that buy-in from the health sector required realization of benefits to include health outcomes framed as the potential to improve the quality of life and the process of recovery; sustainable behavior change required a culture that promoted nurturing care highlighting the role of leadership; subsequently improving the experience of frontline staff and at an individual level, this could be achieved through the provision of supportive supervision-rooted in a framework of compassion. The lessons learned are shared to be considered for future integration efforts.
Do Parks Help Forests?
Authors: Schmit John Paul , Miller Kathryn , Matthews Elizabeth R. , Brolis Andrejs
Published: June 2022

National Parks were created to help protect nature. But does that protection really matter? Are forests inside parks actually any better off than nearby forests outside of parks? How could you even tell? To find out, we studied thousands of trees inside of parks. We measured every tree’s diameter to see how big it was and returned 4 years later to see how they had changed. Then we compared the trees in parks to thousands of other trees that had been measured in similar unprotected forests nearby. It turns out that there are more trees growing in parks, and large trees are much more common. Trees in parks are less likely to die, but due to their large size, they grow more slowly. Parks even have more dead trees and dead wood on the forest floor. All of these things are signs of a healthy forest.
An ALMA Observation of Time Variations in Chromospheric Temperature of a Solar Plage Region
Authors: Abe Masashi , Shimizu Toshifumi , Shimojo Masumi
Published: June 2022

Nanoflares and the shock formation of magnetohydrodynamic waves in the solar chromosphere have been considered as key physical mechanisms of the heating of the chromosphere and corona. To investigate candidates of their signature in the mm-wavelength, a tiny active region located on the solar disk was observed with the Atacama Large millimeter and sub-millimeter Array (ALMA) at 3 mm, coordinated with observatories on orbit including Hinode SOT spectro-polarimeter in the Cycle 4 solar campaign (19 March 2017). ALMA’s spatial resolution was moderate, far from the best performance, but it provided stable conditions that are suitable to investigate temporal variations in the mm-wavelength. We determined that the noise level is less than 20 K (σ) over 1 hour in the 20-s cadence time series of synthesized ALMA images. The time variations with amplitudes above the noise level were observed throughout the field of view, but variations exceeding 200 K, corresponding to energy input to the chromosphere on the order of 1020-22 erg, were localized in two locations. One location was on the polarity inversion line, where tiny concentrated magnetic patches exist in weak field and a tiny magnetic flux may be emergent. The other location was at the outer edge of a bipolar magnetic region, which was under development with a successive series of magnetic flux emergence. This observation suggests that nanoflare-class energy inputs in the chromosphere can occur associated with emerging flux activities.