bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of two different self-paced training modalities on the aerobic fitness level, psychophysiological responses and antioxidant status in young well-trained adults
Authors: Soylu Yusuf , Krustrup Peter , Mohr Magni , Arslan Ersan , Kilit Bulent , Radzimiński Łukasz
Published: October 2023

This study aims to investigate the effects of self-paced high-intensity interval training (Sp-HIIT) vs self-paced moderate-intensity continuous training (Sp-MICT) on the aerobic fitness level, psy-chophysiological responses and antioxidant status, to assess the relationship between aerobic fit-ness level and antioxidant markers. Well-trained males were randomised into Sp-HIIT and Sp-MICT. The intervention consisted of 3 weekly sessions during an 8-wk period. Sp-HIIT per-formed two sets of 12–24 x 30-s high-intensity runs ≥85 %HRmax followed by 30-s rest periods, while Sp-MICT performed 24-48 min of continuous running at 60-75 %HRmax. Pre and post-intervention testing included maximal oxygen uptake (VO2max) assessment during a 30-15 intermittent fitness test (30-15 IFT), as well as resting blood samples analysed for oxidative stress markers (Malondialdehyde (MDA)) and intracellular antioxidant enzymes activity (Catalase (CAT), Superoxide Dismutase (SOD) and Reduced (GSH) and Oxidized Glutathione (GSSG)). The Sp-HIIT showed meaningfully greater improvement in velocity of 30-15 IFT, VO2max and MDA responses. Furthermore, the Sp-HIIT demonstrated higher psychophysiological responses than the Sp-MICT, except for anger responses. In conclusion, these results suggest that Sp-HIIT has higher level of exercise-induced beneficial effects in physiological responses with greater perceived exer-tion in young well-trained adults.
Explainability of Automated Fact Verification Systems: A Comprehensive Review
Authors: Vallayil Manju , Nand Parma , Yan Wei Qi , Allende-Cid Héctor
Published: October 2023

The rapid growth of Artificial Intelligence (AI) has led to considerable progress in Automated Fact Verification (AFV). This process involves collecting evidence for a statement, assessing its relevance, and predicting its accuracy. Recently, research has begun to explore automatic explanations as an integral part of the accuracy analysis process. However, the explainability within AFV is lagging compared to the wider field of explainable AI (XAI), which aims at making AI decisions more transparent. This study looks at the notion of explainability as a topic in the field of XAI, with a focus on how it applies to the specific task of Automatic Fact Verification. It examines the explainability of AFV, taking into account architectural, methodological, and dataset-related elements, with the aim of making AI more comprehensible and acceptable to the general society. Although there is a general consensus on the need for AI systems to be explainable, there a dearth of systems and processes to achieve it. In this research, we investigate the concept of explainable AI in general and demonstrate its various aspects through the particular task of Automated Fact Verification. We explore topic of faithfulness in the context of local and global explainability and how these correspond with architectural, methodological and data-based ways of achieving it. We examine these concepts for the specific case of AFV and analyze the current datasets used for AFV and how they can be adapted to further the identified aims on XAI. The paper concludes by highlighting the gaps and limitations in current data science practices and possible recommendations for modifications in architectural and data curation processes that would further the goals of XAI.
Design and Development of Novel Compounds Aimed at Optimizing the Function of Microtubules and Tubulin in the Immune System and the Brain
Authors: Ruggiero Marco
Published: October 2023

Here, I describe the design and development of novel compounds aimed at optimizing the function of microtubules and tubulin in the immune system and the brain as they relate to the Orch OR theory of consciousness. These compounds are defined by the following molecular formulas:C65H100CoN15O22P(C6H12O5);C65H100CoN15O22P(C5H10NO4);(C65H100CoN15O22P)(C6H12N2O)n;(C65H100CoN15O22P)(C6H12O5)(C6H12N2O)n;(C6H12N2O)n(C6H12O5)m;Zn(C6H12O5)2;These molecules, formulated under the form of drugs or food supplements, have the potential to positively affect a number of areas ranging from prevention and therapy of neurological diseases to supporting the immune system.
Applications and Market of Microorganism-Based and Plant-Based Inputs in Brazilian Agriculture
Authors: Soares Cláudio Roberto Fonsêca Sousa , Hernández Anabel González , Da Silva Emanuela Pille , De Souza Julia Emanuela Almeida , Bonfim Danyella Fernandes , Zabot Giovani Leone , Ferreira Paulo Ademar Avelar , Brunetto Gustavo
Published: October 2023

The use of plant-based and microorganism-based biological inputs is a sustainable agricultural practice, promoting a suitable and better utilization of non-renewable resources in the environment. The benefits of using microorganisms are associated with both direct and indirect mechanisms, primarily related to improvements in nutrient absorption and availability, as well as plant growth. The main benefits of using biochemical pesticides are the promotion of sustainability and the management of resistance. Although the use of microorganisms and botanical metabolites is a promising agricultural alternative, it is still primarily concentrated in grain crops. However, due to the wide range of mechanisms of action of plant-based and microorganism-based biological inputs, there is an opportunity to expand their use in agriculture. In the Brazilian biological inputs market, various terminologies have been used to characterize biological-based products, with many of these terms being employed incorrectly and sometimes conflicting with the country’s legislation. Therefore, this review presents the classes of biological inputs and the application and evolution of the plant-based and microbiological-based product market in different crops in Brazil.
Grappling with the Issue of Motherhood in Women with Schizophrenia
Authors: Seeman Mary V.
Published: October 2023

While persons with schizophrenia find steady employment difficult to sustain, many of the women take on the most difficult task of all – motherhood. The aim of this paper is to review the challenges of motherhood in this population and the treatment strategies needed to keep mothers and children safe, protecting health and fostering growth. This is a narrative review reflecting the author’s life experience and a non-systematic search of the recent literature. Topics added are the stigma against motherhood in the context of schizophrenia, mothers’ painful choices, issues of contraception, abortion, and child custody, fostering and kin placement of children, the effects of antipsychotics, specific perinatal delusional syndromes, and parental supports. Recommendations are to work collaboratively with mothers who struggle with serious mental illness, take note of their strengths as well as their failings, offer a wide array of family services, monitor closely for safety, and appreciate the challenges these women daily face.
The Analysis of Requirements Engineering Tools for the Needs of Practitioners
Authors: Ozkaya Mert , Kardas Geylani , Kose Mehmet Alp
Published: October 2023

Many requirements engineering tools have been existing for gathering, documenting and tracing requirements that can even be further processed for such purposes as analysis and transformation. In this study, we analysed 56 different requirements engineering tools for a comprehensive set of features that are categorised into multiple viewpoints (i.e., project management, specification, collaboration, customisation, interoperability, methodology, knowledge management). The analysis results led to many interesting findings. Some of them are as follows: (i) the project planning and execution activities are rarely supported, (ii) multi-user access and versioning are highly supported, (iii) the top-popular specification technique is natural languages, while precise specification via modeling languages is rarely supported, (iv) requirements analysis is rarely supported, (v) requirements transformation is considered for generating documents only, (vi) tool customisation via the tool integration and API support is highly popular, while customising the notation set is rarely supported, (vii) exchanging requirements is popular in such standards as ReqIF and Excel/CSV, while no single standard are accepted by all the tools, (viii agile development is very common, while other methodologies (e.g., MDE and SPLE) are rarely supported, and (viii) user-guide, telephone, e-mail, videos are the top methods for sharing knowledge. The analysis results will be useful for different stakeholders including practitioners, tool vendors and researchers.
Systematic Investigation into Evolution of Materials and Technique Used in Lacquer Lian from Warring States Period to Yuan Dynasty
Authors: Wu Hao , Zhao Yang , Fang Beisong , Dong Jingren
Published: October 2023

Seven pieces of Lacquer Lian from Warring States Period to Yuan Dynasty (475 BC- 1368 AD) were analyzed by means of cross-section observation, Raman spectroscopy (RS) and thermally assisted hydrolysis and methylation pyrolysis coupled with gas chromatography/ mass spectroscopy (Py-GC/MS). The results demonstrated that Lacquer Lian was consisted by three layers, including pigment layer in the surface, undercoat layer in the middle and ground layer, the red mineral pigment was cinnabar, and mixture of Chinese lacquer and drying oil was applied as main organic materials. Although lacquering techniques had undergone minimal changes from Warring States Period to Yuan Dynasty, the species of drying oil had changed based on the fact that boiled tung oil was found in the ground layer of lacquerwares from Song Dynasty and Yuan Dynasty. The present research provided direct evidence for the inheritance and development of Chinese lacquer technology.
Separation and Purification of Xylooligosaccharides from By-Products of Some Food Industries in Mongolia
Authors: Chinbat Odgerel , Erdenetsog Purevdulam , Janlav Munkhtstetseg , Tuvshintur Buyankhuu , Chimeddorj Battogtokh , Burenjargal Munkhjargal
Published: October 2023

Xylooligosaccharides (XOS) are components of hemicellulose and can be found in wheat bran, and barley hulls. Structurally, XOS consist of two to six xylose residues linked by β-(1,4) bonds. This makes them susceptible to subsequent treatment by intestinal bacteria, but the concentration of XOS is too low to show any prebiotic effects. Some industrial wastes, including brewers’ spent grain (BSG) and wheat bran peels (WBP), represent a major source of xylan, from which XOS is produced to provide a prebiotic effect in populations of colonic commensal microbiota. WBPs and BSGs were treated by microwave and enzymatic hydrolysis. Using the designed microwave pretreated enzymatic hydrolysis, 5.4 g of dry XOS was produced from 50 g WBP powder and 3.6 g dry XOS was produced from 50 g BSG powder. A single microwave treatment on WBP and BSG before enzymatic hydrolysis and 0.25 g/100 g enzyme raw material ratio were determined to be optimal. Effective microwave-assisted enzymatic hydrolysis of WBP and BSG were investigated, and contribute to improving the effectiveness of xylanase on WBP and BSG. Microwave-assisted enzymatic hydrolysis with xylanase and purification, obtaining food-grade XOS, was demonstrated as a step toward industrial-scale production.
KESESUAIAN PUTUSAN HAKIM DALAM PERKARA ANAK SEBAGAI PERANTARA JUAL BELI NARKOTIKA DENGAN UU SPPA
Authors: Wisnu Wardani Laksmidari Khansa Bella , Kristiyadi Kristiyadi
Published: October 2023

This article aims to find out the legal considerations used by Judges in deciding a narcotics case with a child who acts as an intermediary for buying and selling narcotics in the study of verdict Number 4/Pid.Sus-Anak/2022/PNWng. The method used in this research is normative legal research that is prescriptive and applied. The research approach uses a case approach. The types of legal materials used are primary legal materials and secondary legal materials with library research/ document studies. Based on the research, the results obtained were that the judge's considerations in deciding criminal cases with children as defendants were in accordance with the Law on Juvenile Justice System. Children Against the Law have fulfilled the elements of the article charged by the Public Prosecutor through evidence that is in accordance with Article 183 of the Criminal Procedure Code. In addition, the trial is also in accordance with the provisions of the Law on Juvenile Justice System where children are tried based on the Juvenile Criminal Justice System. However, in sentencing, the judge felt that he had not been optimal in his considerations where the judge still ruled out several articles and principles in the Law on Juvenile Justice System which affected the outcome of the decision in sentencing.

Keywords: Children Against the Law; Narcotics Sale and Purchase Intermediary; The Law on Juvenile Justice System
KESALAHAN PENERAPAN HUKUM SEBAGAI ALASAN KASASI TINDAK PIDANA TURUT SERTA MEMALSUKAN SURAT SECARA BERLANJUT
Authors: Raflyansyah Arief Agha , Septiningsih Ismawati
Published: October 2023

This legal research aims to find out the misapplication of the law by the District Court Judge as the reason for the Public Prosecutor's cassation against the acquittal in the criminal case of participating in forging letters related to the provisions of Article 253 paragraph (1) of the Criminal Procedure Code and the suitability of the Supreme Court's consideration in examining and deciding the Public Prosecutor's cassation in Supreme Court Decision Number 1086 K/Pid/2022. This legal research is a prescriptive and applied normative legal research with a case study approach. The source of legal material for this research comes from primary legal materials and secondary legal materials. The legal material collection technique used is document study or literature study. The technique of analyzing legal materials in this study uses the syllogism method with deductive thinking patterns. The results of the research and discussion obtained are that the Public Prosecutor can prove the suitability of the reasons for cassation submitted by him with the reasons for cassation contained in Article 253 paragraph (1) of the Criminal Procedure Code, namely in terms of whether it is true that a legal rule is not applied or applied improperly. Therefore, the Supreme Court granted the cassation of the Public Prosecutor and found the defendant guilty of committing the crime charged, then imposed a prison sentence of 6 (six) month.
Keywords: Cassation, Mail Forgery, Acquittal Decision.
KESESUAIAN PERTIMBANGAN HAKIM DALAM PUTUSAN NOMOR 1/Pid.Sus-Anak2022/PN BYL DENGAN UU SPPA
Authors: Muharam Azzam Zaid , Santoso Bambang
Published: October 2023

This writing analyzes the suitability of the judge's considerations in imposing a prison sentence of two years and three months of job training for children with Article 71 paragraph (3) and Article 79 of the Law of the Republic of Indonesia Number 11 of 2012 concerning the Juvenile Justice System. In Decision Number 1/Pid.Sus-Anak/2022/PN Byl it is known that there has been a criminal act of sexual intercourse with a child, which was committed by a child. Child offenders are subject to Article 81 paragraph (2) of Law Number 17 of 2016 concerning Stipulation of Government Regulation in lieu of Law Number 1 of 2016 regarding the second amendment to Law Number 23 of 2002 concerning Child Protection. The Child Protection Act can be applied to anyone, regardless of whether the offender is an adult or a child. So to protect child perpetrators, the Law of the Republic of Indonesia Number 11 of 2012 concerning the Juvenile Justice System is enacted. The purpose of this writing is to find out whether the judge's considerations in Decision Number 1/Pid.Sus-Anak/2022/PN Byl are in accordance with the Law of the Republic of Indonesia Number 11 of 2012 concerning the Juvenile Justice System. As a result, the judge in his considerations before making a decision had considered Article 71 paragraph (3) of the Law of the Republic of Indonesia Number 11 of 2012 concerning the Juvenile Justice System.

 Keywords: Consideration; Intercourse; Child
ANALISIS PERTIMBANGAN HAKIM DALAM MEMUTUS PERKARA PENCEMARAN NAMA BAIK MELALUI FACEBOOK
Authors: Anggraeni Iftita Zahra , Harjono Harjono
Published: October 2023

This article was written with the aim of knowing the judge's considerations in deciding a defamation case via Facebook based on Decision Number: 303/Pid.Sus/PN Tbt. The method used in this research is normative or docryal which is prescriptive and applied with a case approach. Techniques for collecting primary and secondary legal materials are obtained from document studies or literature. The law material analysis technique used is the syllogism method which uses a deductive mindset. Based on the results of the research and discussion it is known that the judge's considerations in deciding the criminal act of defamation through Facebook are in accordance with the elements in Article 45 paragraph (3) Jo. Article 27 paragraph (3) Law of the Republic of Indonesia Number 19 of 2016 concerning Amendments to Law of the Republic of Indonesia Number 11 of 2008 concerning Information and Electronic Transactions. The judge in deciding the case has used at least 2 (two) valid pieces of evidence in accordance with Article 184 of the Criminal Procedure Code, namely witness statements, expert statements, and defendant statements.
Keywords: Judge's consideration; Defamation; Evidence
KESESUAIAN PERTIMBANGAN HUKUM HAKIM TERHADAP TINDAK PIDANA NARKOTIKA DENGAN SEMA NOMOR 3 TAHUN 2015
Authors: Lintario Yohanes Galih , Putri Hanuring Ayu Ardhani
Published: October 2023

Abstract: This article analyzes the suitability of judges' considerations with SEMA Nomor 3 of 2015 in
imposing criminal penalties for narcotics crimes. This study aims to find out whether the judge's legal
considerations in imposing a sentence on Decision Nomor: 3557 K/Pid.Sus/2021 are in accordance with
SEMA Nomor 3 of 2015. This research is a normative legal research that is prescriptive and applied. The
legal material collection technique used in this study is the document study technique or library study
technique. The collection of legal materials is carried out through document studies and literature studies.
Based on the results of the study, it was shown that the basis for legal considerations was that the judge
made a decision in the form of convicting the defendant based on juridical and non-juridical considerations
in accordance with the facts revealed in the trial. The judge's considerations in imposing a criminal decision
against the Defendant are in accordance with SEMA Nomor 3 of 2015.

Keywords: Narcotics; Narcotics Crime; Judge's Legal Considerations
Discontinuous clogging in gently tapered microchannels reveals a transient Markov process
Authors: Majekodunmi Olukayode , Hashmi Sara
Published: October 2023

Colloidal clogging is typically studied in pores with constrictions arranged in parallel or series.
In these systems, clogging statistics are governed by Poisson processes; the time interval between
clogging events exhibits an exponential distribution. However, an entirely different phenomenon
is observed in a gently tapered pore geometry. Unlike in non-tapered constrictions, rigid particles
clogging tapered microchannels form discrete and discontinuous clogs. In a parallelized system of
tapered microchannels, we analyze distributions of clog dimensions for different flow conditions. Clog
width distributions reveal a lognormal process, arising from concurrent clogging across independent
parallel microchannels. Clog lengths, however, which are analogous to growth time, are exponentially
distributed. This indicates a Poisson process where events do not occur simultaneously. These two
processes are contradictory: clogging events are statistically dependent within each channel while
clogs grow simultaneously across independent channels. The coexistence of Poisson and lognormal
processes suggests a transient Markov process in which clogs occur both independently of, and
dependently on, other clogs. Therefore, discussions of the stochastic character of clogging may
require holistic consideration of the quantities used to assess it. This study reveals small adjustments
to pore spaces can lead to qualitative differences in clogging dynamics, suggesting the importance
of geometry.
Hyperphagia and Impulsivity: Use of self-administered Dykens' and in-house Impulsivity questionnaires to characterize eating behaviors in children with severe and early-onset obesity
Authors: Arnouk Lara , Chantereau Hélène , Courbage Sophie , Tounian Patrick , Clément Karine , Poitou Christine , Dubern Beatrice
Published: October 2023

Background The determinants of early-onset obesity (< 6 years) are not completely elucidated, however eating behavior has a central role. To date no study has explored eating behavior in children with severe, early-onset obesity. Self-administered questionnaire data from these children were examined to evaluate eating behavior and the etiology of early-onset obesity.
Methods Children with severe, early-onset obesity (body mass index [BMI] > International Obesity Task Force [IOTF] 30) of different etiologies (hypothalamic obesity [HO], intellectual disability with obesity [IDO], common polygenic obesity [CO]) were prospectively included. BMI history and responses from the Dykens’ Hyperphagia Questionnaire and an in-house Impulsivity Questionnaire at first visit were compared between groups.
Results This cohort of 75 children (39 girls; mean age ± standard deviation [SD] 10.8±4.4 years) had severe, early-onset obesity at an age of 3.8±2.7 years, with a BMI Z-score of 4.9±1.5. BMI history varied between the 3 groups, with earlier severe obesity in the HO group versus 2 other groups (BMI > IOTF40 at 3.4±1.6 vs. 4.6±1.6 and 8.4±4.1 years for the IDO and CO groups, respectively [P < 0.01]). Absence of adiposity rebound was more prevalent in the HO group (87% vs. 63% and 33% for the IDO and CO groups, respectively [P< 0.01]). The Dykens’ mean total score for the cohort was 22.1±7.2 with no significant between-group differences. Hyperphagia (Dykens’ score > 19) and impulsivity (score > 7) were found in 50 (67%) and 11 children (15%), respectively, with no difference between the HO, IDO and CO groups regarding the number of patients with hyperphagia (10 [67%], 14 [74%], and 26 [63%] children, respectively) or impulsivity (2 [13%], 1 [7%], and 8 [19%] children, respectively). Children with food impulsivity had significantly higher total and severity scores on the Dykens’ Questionnaire versus those without impulsivity.
Conclusion The Dykens’ and Impulsivity questionnaires can help diagnose severe hyperphagia with/without food impulsivity in children with early-onset obesity, regardless of disease origin. Their systematic use can allow more targeted management of food access control in clinical practice and monitor the evolution of eating behavior in the case of innovative therapeutic targeting hyperphagia.
Identification of shared Gene/Drug and Gene/Disease genetic associations in a mental health/substance use disorder patient population across an addiction treatment network using Pharmacogenomic testing
Authors: Silverman Steven
Published: October 2023

The human cost in terms of death and disability in individuals with mental health and addiction disorders and the subsequent destructive effect on families and communities in the United States has emerged as a significant public health burden in recent years. The discovery of any shared genetic associations underlying co-existing psychiatric and addiction disorders in this patient population could lead to the development of new treatment strategies based on identification of certain gene biomarkers in genetically susceptible individuals in addition to expanded clinical use of pharmacogenomic-guided medication management. To address these critical public health issues, the Recovery Treatment Centers of America (RCA) implemented a network-wide mental health initiative employing pharmacogenomic (PGx) testing as a tool to aid healthcare providers in enhancing clinical decision-making in drug prescribing. Single nucleotide polymorphism (SNP) genotyping analysis was performed on genomic DNA isolated from buccal swab specimens and analyzed using real time polymerase chain reaction (qPCR). This retrospective observational study aimed to identify significant pharmacokinetic gene/drug associations that impact patient medication regimens and explore pharmacodynamic genes that may influence clinical responses in a population of individuals with mental health/substance use disorders.
Reform of the first year of medical studies and diversification of student profiles in France: an unmet need?
Authors: Khanna Raoul Kanav , Blanchard Emmanuelle , Pasco Jeremy , Diot Patrice , Angoulvant Denis
Published: October 2023

Objectives: To determine whether the reform of the first year of medical studies implemented in September 2020 in France met its objective of diversifying the profiles of students admitted to second year at the faculty of medicine at the University of Tours.
Methods: Single-centered, retrospective study, covering students who passed the first year of medical studies between 2018 and 2022. Student profiles originating from three different entry gateways (PACES, PASS and L.AS) to the second year of medical studies were compared.
Results: 1479 students over five promotions were included. The ratio of students who had obtained a scientific baccalaureate was 98.8% in the reform year compared to 99.2% in average to the previous years. For students in the reform year, 43.4% passed their high school diploma with highest honors compared to 57.9% in average the previous years while 11.8% obtained their high school diploma with a standard pass, compared to 2.2 % in average the previous years (p < 0.001). These differences were related to increased student intake via a standard pass in L.AS (44.8% to 8.5% in PACES and 1.5% in PASS) (p < 0.001). In terms of geographical origin, the ratio of students domiciled in the territory of the faculty of medicine was one in two students from PACESand PASS (average: 50.5%) compared to one in three from L.AS(33.9%) (p = 0.023). The proportion of students with at least one or both parents from the white-collar and knowledge professional category was higher in PASS (1 parent: 72.8% compared to 57.2% in PACES and 48.2% in L.AS (p = 0.002); 2 parents: 34.6% compared to 26.2% in PACES and 17.9% in L.AS (p = 0.051)).
Conclusions: Students with a scientific background and who obtained highest honors in their high school diploma, remain the standard in PACESand PASS. Diversification of student profiles was achieved only within the L.AS gateway, which represented only a minority of students (17%) of total second year admissions. Student profile diversification was therefore a partially achieved objective and follow up studies of future promotions is needed to assess the medium and long-term impact of the reform. Particular attention should be paid to the future of these students who have different profiles between L.ASand PASS to determine whether these changes will have any impact in the quality of healthcare for the French population.
Machine learning-based radiomic models for predicting metachronous liver metastases in colorectal cancer patients: a multimodal study
Authors: Wang Jian-Ping , Zhang Ze-Ning , Shu Ding-Bo , Pang Zhen-Zhu , Luo Fang-Hong , Huang Ya-Nan , Tang Wei , Zhao Zhen-Hua , Sun Ji-Hong
Published: October 2023

Purpose
The purpose of this study was to investigate whether a multimodal radiomic model powered by machine learning (ML) can accurately predict the occurrence of metachronous liver metastases (MLM) in patients with colorectal cancer (CRC).
Patients and methods:
A total of 157 consecutive patients with CRC between 2010 and 2020 were retrospectively included. Out of these patients, 67 experienced liver metastases within 2 years of treatment, while the remaining patients did not. Radiomic features were extracted from annotated MR images of the tumor and portal venous phase CT images of the liver for each patient. Following that, ML-based radiomic models were then developed and integrated with the clinical features for MLM prediction by employing LASSO and RF algorithms. The performance of the model was evaluated using the ROC curve, while the clinical utility was measured using the DCA curve.
Results
A total of 922 and 1216 radiomic features were extracted from the MRI and CT images of each patient, quantifying the intensity, shape, orientation, and texture of the tumor and liver, respectively. The mean area under the curves(AUCs) for predicting metachronous liver metastases were 0.80, 0.68, and 0.82 for the CT, MRI, and Merged models, respectively. For the Clinical and Clinical-Merged models, the AUCs were 0.64 and 0.72, respectively. There was no significant difference between the CT model and the Merged model (p < 0.05).
Conclusion
Our preliminary results demonstrate the utility of ML-based radiomic models in predicting MLM in patients with CRC. However, further investigation is required to explore the potential of multimodal fusion models, as they offered only minimal improvement in diagnostic performance.
Effects of exogenous application of abscisic acid and melatonin on biochemical and molecular traits of Salicornia europaea under salinity stress
Authors: Qarehkhani Mehrnesa , Soltanlooh hassan , mokhtarpour hassan , ramezanpour sanaz , khorasaninejad sara , Akbarboojar masoud Mashhadi , tavakol elahe
Published: October 2023

Salinity is a major factor limiting agricultural lands that causes adverse effects on plant growth and production. The use of exogenous compounds or growth regulators has often been effective in reducing the effects of environmental stresses and/or identifying stress-coping mechanisms in plants. Among 1560 halophytes, Salicornia europaea is known as a salt-tolerant species. This study aimed to understand the effects of the endogenous application of abscisic acid (ABA) and melatonin hormones and their combined effects on mechanisms involved in plant resistance to salinity stress to identify these mechanisms, genes associated with ion channels, and antioxidant enzymes involved in response to stress using real-time technology. S. europaea metabolism compounds, namely hydrogen peroxide (H2O2), malondialdehyde, proline, phenol, sodium, potassium, and calcium were studied in control plants and under 400 mM salinity stress at 0, 6, 48, and 720 h (1 month) intervals. The best effects in terms of morphological, biochemical, and molecular traits were observed in spraying with both hormones at 400 mM salinity. This treatment reduced polyphenol oxidase activity, malondialdehyde content (by 35%), and H2O2 content, while it increased shoot (2.04 times) and root (76%) wet weights, shoot dry weight (2.45 times), K (by 19%) and Ca (by 79%) contents, and the Na/K ratio (by 30%). ABA spraying elevated catalase activity at 400 mM salinity. Spraying treatments led to the overexpression of SOD (by 21 times), SOS1 (by 1218 times), NHX1 (by 16 times), APX (by 214 times), HKT1 (by 470 times), and VHA-A (by 27 times) genes in some treatments compared to NT plants. The rapid response to stress is the main difference between stress-sensitive and tolerant plants. Spraying treatments resulted in elevated overexpression of genes involved in stress-responding mechanisms at early hours of salinity stress compared to control treatments, thereby increasing the tolerance of S. europaea to salinity stress.
“An explosion of alternative medicines in France!”: media-biased polyphonic epidemiology vs. evidence-based data
Authors: Berna Fabrice , Florens Nans , Verneuil Laurence , Paille François , Berna Chantal , Nizard Julien
Published: October 2023

Background: The media and several French official organizations report an “explosion” in the use of complementary and alternative medicines (CAM) in France, possibly “boosted” by the Covid-19 pandemic. In addition, the French Miviludes (Mission of Vigilance and Fight Against Sectarian Aberrations) routinely asserts in its yearly reports “a dramatic uptick” in sectarian aberrations in the health sector. However, data supporting those assertions are either scant or rarely compared with data from previous years to properly apprehend an evolution.
This paper aims to analyze existing data in this field and to examine in which domain (population-based survey, official reports, media) “increases” or “explosion” might be observed. We compared the data from France and Switzerland. In fact, no clear regulatory policy on CAM exists in France, whereas the Swiss population voted to include CAM into the Swiss Constitution in 2009.
Method: Surveys documenting the reported usage of CAM in both France and Switzerland were analyzed. Health-related sectarian aberrations were analyzed based on yearly reports of the French Miviludes and its Swiss counterpart (Inter-Cantonal Information Center on Beliefs). Then, the communication in the media on CAM was analyzed in the French media and in the scientific literature published in both countries. Three time periods were considered to apprehend the claimed boost of the Covid-19 pandemic.
Results: Our comprehensive analysis of available information sources does not suggest an “explosion” in CAM use or related sectarian misconduct. Reported CAM use in France was 39% in 2007 and later surveys did not find higher percentage. Reported CAM use increased from 24% to 28.9% between 2007 and 2017 in Switzerland. Referrals about health-related sectarian aberrations regularly increased until 2017 and then remained stable in France; they regularly decreased in Switzerland. Evidence for a pandemic boost was weak. In contrast, a steady increase was observed in the number of mentions in media of CAM.
Conclusion: Our analyses indicate a media-skewed, polyphonic epidemiology, which is not supported by available data. Health care specialists, Official organizations, journalists and politicians should become aware of biases concerning CAM and foster a more informed and balanced discourse regarding these practices.
Antiviral Activities of Aqueous Extracts of Aerial Parts of Spring and Autumn-harvested Artemisia aucheri Bioss. on Herpes Simplex Virus Type 1
Authors: Zamanian Mahsa , Afaridoon Sahar , Asgari Emad , Bineshian Farahnaz , Saeedi Mina , Sharifi Zohreh
Published: October 2023

Background
In this study, Artemisia aucheri extracts (the vernal and Autumnal extracts) were used to investigate their antiviral effects against HSV-1. In the present paper, we aimed, to investigate the antiviral effects of Artemisia aucheri extracts of the vernal and autumnal against HSV-1 and also, the expression of the US6 gene and its protein level in cell culture.
Methods
The toxicity of the extracts was directly studied at different concentrations using the MTT assay on the Vero cell line. Also, the effects of Artemisia aucheri extracts on the gene expression of Herpes simplex virus 1 (HSV-1) US6 (gD) and protein synthesis were investigated using q-PCR and western blot methods, respectively.
Results
Our findings indicated that HSV-1 US6 gene expression was significantly decreased (P < 0.05) after being infected with the virus and adding Artemisia aucheri aqueous extracts at the same time. Also, the reduction of HSV-1 gD protein expression was confirmed by the western blot assay.
Conclusions
Artemisia aucheri aqueous extracts could be a new effective and potential treatment candidate for HSV-1 infections.
Application of flipped classroom combined with PBL teaching method in breast surgery teaching
Authors: Guo Lijing , Wang Xuewei , Li Zonghan , Li Zhaoyue
Published: October 2023

Construct: Effectiveness of problem-based learning (PBL) combined with flipped classroom in breast surgery practical training.
Findings: The experimental group, which received PBL combined with flipped classroom teaching, demonstrated significantly superior results in subjective evaluations, theoretical examination scores, practical examination scores, and learning indicators compared to the control group (P < 0.05).
Conclusions: The combination of PBL and flipped classroom teaching methods not only heightens students' enthusiasm for learning but also bolsters their self-learning capability, problem-solving skills, teamwork ability, and facilitates the effective assimilation of theoretical knowledge and practical skills in breast surgery for clinical medical students.
Thrombosed MCA aneurysm mimicking an insular Cavernous Angioma:a case report and literature review
Authors: Soler-rico Morgane , Finet Patrice
Published: October 2023

Introduction
Cerebral cavernous malformations (CCM) can mimic other lesions such as thrombosed aneurysms. Completely thrombosed aneurysms (CTA) are rare, especially in non-giant aneurysms.
Case presentation
We report a case of 40-year-old man with a presumed insular CCM. A surgery was performed and revealed a thrombotic distal middle cerebral artery (MCA) aneurysm. The treatment consisted in sac incision and partial debulking. We reviewed the cases of thrombotic non-giant CTA and lesions mimicking CCM in the literature.
Conclusion
Complete radiologic analysis and differential diagnosis remain crucial. For non-giant CTA, there is no clear consensus on their management, but they could be managed conservatively.
Gene therapy for hemophilia B in immature mice using ScAAV-DJ/8-LP1-hFIXco vector
Authors: Tang Yong Min , Bu Zi Bin , Lou JinTu , Xu Wei Qun , Zhang Ling Yan
Published: October 2023

Hemophilia B is an X-linked bleeding disorder that derives from the mutation in the gene encoding coagulation factor IX(FIX). Gene therapy provided the promising hope to cure the disease. Currently, pure virus injection is exclusively limited to adults, resulting in favorable outcomes. However, this approach has rarely been tested in pediatric patients due to its considerable impact on liver function. Therefore, it is necessary to develop a safer alternative approach for children. In this paper, we have successfully developed a novel ScAAV-DJ/8-LP1-hFIXco vector as a gene therapy tool for treating hemophilia B in immature mice. This work could potentially provide new evidence for gene therapy in pediatric patients with hemophilia B. Moreover, the ScAAV-DJ/8-LP1-hFIXco vector may hold promise as a potential treatment option for pediatric and adult patients with hemophilia B.
Prevalence of electrographic seizures in hospitalized patients with altered mental status with no significant seizure risk factors who underwent continuous EEG monitoring.
Authors: GARRIDO ELENA , Adeli Amir , Echeverria-Villalobos Marco , Diaz Juan Fiorda , Hannawi Yousef
Published: October 2023

Objectives To evaluate the prevalence of electrographic seizures in hospitalized patients with altered mental status and no significant risk factors for seizures.Methods We retrospectively reviewed over a six-year period (2013–2019) the medical records of all adults admitted at Ohio State University Wexner Medical Center (OSUWMC), who underwent cEEG monitoring for ≥ 48 hours. Our primary objective was to identify the prevalence of electrographic seizures in patients with altered mental status and no significant acute or remote risk factors for seizures.Results A total of 1966 patients were screened for the study, 1892 were excluded (96.2%) and 74 patients met inclusion criteria. Electrographic seizures were identified in seven of 74 (9.45%). We found a significant correlation between electrographic seizures and history of hepatic cirrhosis, n = 4 (57%), (p = 0.035), acute on chronic hepatic failure during admission, 71% (n = 5), (p = 0.027), and hyperammonemia (p = 0.009).Conclusion In this retrospective study of patients with altered mental status and with no significant acute or remote risk factors for seizures who underwent cEEG monitoring for ≥ 48 hours, electrographic seizures were identified in 9.45%. Electrographic seizures were associated with hepatic dysfunction and hyperammonemia. Based on our results, cEEG monitoring should be considered in patients with altered mental status and hepatic dysfunction even in the absence of other seizure risk factors.
Analysis of maternal factors affecting the occurrence of congenital heart disease in newborns in Lanzhou area and potency of a nomogram prediction model
Authors: Jiao Xinjuan , Sun Jianhao , Jing Yiting , Guo Guangmin , Li Fen , Guo Minhao , Gao Jing , Ren Wenkang , He Jing , Liu Qing , Tuo Shumei
Published: October 2023

Objective
To analyze the maternal influencing factors of neonatal congenital heart defects (CHDs), to achieve the effect of prevention of neonatal CHDs.
Methods
A questionnaire survey was conducted on 134 newborns with CHDs from March 2022 to January 2023 as the case group, and 268 pregnant women were included in the control group according to the 1: 2 matching principle with age as the matching condition. Baseline data, pregnancy complications, and other clinical data of all subjects were collected. Logistic regression analysis was used to screen the risk factors affecting neonatal congenital heart disease. R software was used to construct a nomogram model for predicting the incidence of congenital heart disease.
Results
Logistic regression analysis showed that hypertensive disorder complicating pregnancy ( HDCP ) was a risk factor for CHDs ( OR = 3.77,95% CI : 2.18–6.53 ), gestational diabetes mellitus ( GDM ) was a risk factor for CHDs ( OR = 3.69,95% CI : 2.11–6.46 ), and keeping cats during pregnancy was a risk factor for CHDs ( OR = 2.73,95% CI : 1.02–7.34 ). The probability of GDM leading to congenital heart disease in offspring was 49.70%, the probability of HDCP leading to congenital heart disease in offspring was 48.60%, and the probability of raising cats during pregnancy leading to congenital heart disease in offspring was 38.00%.he probability of CHDs in offspring induced by HDCP and GDM was 78.70%, the probability of CHDs in offspring induced by HDCP and cats was 70.90%, the probability of CHDs in offspring induced by GDM and cats was 70.30%, and the probability of CHDs in offspring induced by HDCP, GDM, and cats was 90.50%. The nomogram predicts that the correction curve of the offspring CHDs model approaches the ideal curve.
Conclusion
We established a nomogram model of maternal influencing factors to predict the risk of congenital heart disease in neonates with good differentiation and consistency. This novel predictive model will help clinicians prevent congenital heart disease in offspring by improving maternal influencing factors.
Arsenic sulfide Triggers Ferroptosis in Hepatocellular Carcinoma Cells via TRPC6/GPX4 Signaling
Authors: Lu Shumin , Cai Yu , Kang Ting , Zhu Chuanying , Feng Zhuowei , Chen Shuxian , Chen Siyu
Published: October 2023

Ferroptosis plays a vital role in the pathological process of numerous human diseases, including cancer. It is possible that ferroptosis stimulation could be used as a cancer treatment strategy. Due to this, ferroptosis-inducing drugs are gaining more attention for the clinical treatment of tumors. For the first time, we demonstrated that arsenic sulfide (As4S4) initiated ferroptotic cell death in hepatocellular carcinoma (HCC) cells, which was concomitant with ROS accumulation, lipid peroxidation, and GSH depletion. Arsenic sulfide -mediated cell death in HCC cells was blocked by ferroptosis inhibitors ferrostatin-1 (Fer-1) and deferoxamine (DFO, an iron chelator), but not Z-VAD-FMK, necrosulfonamide, or chloroquine, suggesting that ferroptosis participated in arsenic sulfide -induced cell death. Transient receptor potential channel 6 (TRPC6) expression was notably inhibited under arsenic sulfide intervention and the overexpression of TRPC6 rescued the effects of arsenic sulfide on ferroptosis. Furthermore, glutathione peroxidase 4 (GPX4), was identified to interact with TRPC6 through confocal microscopy images and co-immunoprecipitation assay. In summary, arsenic sulfide exerts anticancer effects on HCC in vitro and in vivo by inducing ferroptosis via inhibiting TRPC6/GPX4 pathway. Our findings led us to conclude that arsenic sulfide could be considered as a prospective drug for liver cancer treatment.
Laparoscopic tumorectomy for an unusual pelvic retroperitoneal leiomyoma: a case report.
Authors: Pace Marco , Moretti Marco , Tierno Simone Maria , Mazzotta Alessandro Dario , Ferroni Andrea Felice , Paolo Marco Di Giovan , Gianfreda Valeria , Bianca Salvatore , Barbarosos Apostolos , Vitelli Carlo Eugenio , Boninfante Michelangelo , Stipa Francesco
Published: October 2023

Introduction:
Leiomyomas are benign tumors, mostly located in the uterus. The pelvic localization is quite rare and it is associated with unusual growth patterns. It is important make an adequate differential diagnosis between malignant and benign retroperitoneal neoplasm because treatment is different. When it is not possible to have a precise preoperative diagnosis, a laparoscopic or laparotomy surgical tumorectomy is often required. To obtain a certain diagnosis, the goal of surgery is ensuring the complete excision of neoplasms and preservation of urination, defecation and sexual function.
Case presentation:
We report a rare case of a 58-year-old woman who underwent a laparoscopic tumorectomy for a pelvic retroperitoneal leiomyoma. The patient reported occasional episodes of dull pain in the pelvic region. Pelvic contrast CT scan and Magnetic Resonance Imaging (MRI) showed a retroperitoneal solid mass in contiguity with the posterior wall of the uterine body-isthmus, to be referred to a pedunculated uterine fibroma strictly posteriorly adherent to the sigma. She was first underwent to explorative laparoscopy by Gynecologist who did not find any uterine mass. The patient was subsequently admitted to Department of General Surgery and has done a second operative laparoscopy which highlighted the presence of an extra-peritoneal para-rectal mass which was completely excised. The histological examination of tumor indicated that it was a leiomyoma. The postoperative course was uneventful and the patient was discharged in III post-operative day (POD).