bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Daily Low-Dose Date Consumption on Glycemic Control, Lipid Profile, and Quality of Life in Adults with Pre- and Type 2 Diabetes: A Randomized Controlled Trial
Authors: Alalwan Tariq A. , Perna Simone , Mandeel Qaher A. , Abdulhadi Aalaa , Alsayyad Adel Salman , D’Antona Giuseppe , Negro Massimo , Riva Antonella , Petrangolini Giovanna , Allegrini Pietro , Rondanelli Mariangela
Published: January 2020

Dates have a low glycemic index and are a source of antioxidants but, nevertheless, contain more than 70% sugar. This study aims to assess the effects of date consumption (three dates daily) on glycemic profile (HbA1c), body mass index (BMI), quality of life, and lipid profile, including total cholesterol, triglyceride, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) in terms of safety for type 2 diabetic mellitus (T2DM) subjects. A randomized controlled trial was conducted with a sample of 100 T2DM subjects (39 male and 61 female) randomly assigned in two groups. The first group received three dates daily for 16 weeks, and the control group avoided date consumption. After a 16-week follow-up period, the study results showed an improvement of lipid profile with a statistically significant decrease in total cholesterol of ∆ = −0.209 mmol/L (confidence interval (CI) 95% −0.358, −0.059; p < 0.05) and in LDL of ∆ = −0.171 mmol/L (CI 95% −0.358, 0.016) in the group receiving three dates daily. Intra-group mean differences of BMI were not statistically different in both groups after 16 weeks of date consumption. Even HbA1c did not change, both within and between groups after date consumption (∆ = 0.087%; CI 95% −0.086, 0.261). Between groups, mean difference changes (intervention minus control) showed a statistically significant improvement of quality of life index of ∆ = ± 30.66 points (CI 95% 12.45, 48.23) due to the consequent improvement in mental health. Although the definitive effect of dose/intake response of date consumption on Hb1Ac, lipid profile, and BMI in T2DM subjects is still to be established, the study suggests that dates could potentially have a beneficial effect on lipid profile, especially in reducing total cholesterol and elevating HDL, because of its high polyphenolic content. In addition, a low–moderate consumption of dates did not impact glucose levels because of dates’ low glycemic index.
RETRACTED: Sanguinarine Inhibits Mono- and Dual-Species Biofilm Formation by Candida albicans and Staphylococcus aureus and Induces Mature Hypha Transition of C. albicans
Authors: Qian Weidong , Wang Wenjing , Zhang Jianing , Liu Miao , Fu Yuting , Li Xiang , Wang Ting , Li Yongdong
Published: January 2020

Previous studies have reported that sanguinarine possesses inhibitory activities against several microorganisms, but its effects on mono- and dual-species biofilms of C. albicans and S. aureus have not been fully elucidated. In this study, we aimed to evaluate the efficacy of sanguinarine for mono- and dual-species biofilms and explore its ability to induce the hypha-to-yeast transition of C. albicans. The results showed that the minimum inhibitory concentration (MIC) and minimum biofilm inhibitory concentration (MBIC90) of sanguinarine against C. albicans and S. aureus mono-species biofilms was 4, and 2 μg/mL, respectively, while the MIC and MBIC90 of sanguinarine against dual-species biofilms was 8, and 4 μg/mL, respectively. The decrease in the levels of matrix component and tolerance to antibiotics of sanguinarine-treated mono- and dual-species biofilms was revealed by confocal laser scanning microscopy combined with fluorescent dyes, and the gatifloxacin diffusion assay, respectively. Meanwhile, sanguinarine at 128 and 256 μg/mL could efficiently eradicate the preformed 24-h biofilms by mono- and dual-species, respectively. Moreover, sanguinarine at 8 μg/mL could result in the transition of C. albicans from the mature hypha form to the unicellular yeast form. Hence, this study provides useful information for the development of new agents to combat mono- and dual-species biofilm-associated infections, caused by C. albicans and S. aureus.
Anti-Metastatic Effects on Melanoma via Intravenous Administration of Anti-NF-κB siRNA Complexed with Functional Peptide-Modified Nano-Micelles
Authors: Ibaraki Hisako , Kanazawa Takanori , Owada Minami , Iwaya Keiko , Takashima Yuuki , Seta Yasuo
Published: January 2020

Controlling metastasis is an important strategy in cancer treatment. Nanotechnology and nucleic acids with novel modalities are promising regulators of cancer metastasis. We aimed to develop a small interfering RNA (siRNA) systemic delivery and anti-metastasis system using nanotechnology. We previously reported that polyethylene glycol-polycaprolactone (PEG-PCL) and functional peptide CH2R4H2C nano-micelle (MPEG-PCL-CH2R4H2C) has high siRNA silencing effects, indicated by increased drug accumulation in tumor-bearing mice, and has an anti-tumor effect on solid tumors upon systemic injection. In this study, we aimed to apply our micelles to inhibit metastasis and evaluated the inhibitory effect of anti-RelA siRNA (siRelA), which is a subunit of NF-κB conjugated with MPEG-PCL-CH2R4H2C, via systemic administration. We report that siRelA/MPEG-PCL-CH2R4H2C had a high cellular uptake and suppressed the migration/invasion of cells in B16F10 cells without toxicity. In addition, in a lung metastasis mouse model using intravenous administration of B16F10 cells treated with siRelA/MPEG-PCL-CH2R4H2C, the number of lung nodules in lung tissue significantly decreased compared to naked siRelA and siControl/MPEG-PCL-CH2R4H2C micelle treatments. Hence, we show that RelA expression can reduce cancer metastasis, and MPEG-PCL-CH2R4H2C is an effective siRNA carrier for anti-metastasis cancer therapies.
Micellization of Polystyrene-b-Polyglycidol in Dioxane and Water/Dioxane Solutions
Authors: Otulakowski Lukasz , Dworak Andrzej , Forys Aleksander , Gadzinowski Mariusz , Slomkowski Stanislaw , Basinska Teresa , Trzebicka Barbara
Published: January 2020

In this work, the self-assembly of a series of amphiphilic polystyrene-b-polyglycidol (PS-b-PGL) diblock copolymers in dioxane and dioxane/water mixtures is presented. The PS-b-PGL have an average degree of polymerization (DP) of PS block equal to 29 units and varied degrees of polymerization for the glycidol segments with DPs of 13, 42, 69 and 117. In dioxane, amphiphilic diblock copolymers form micelles with the hydrophilic PGL placed in the core. Critical micelle concentration (CMC) was determined based on the intensity of scattered light vs. concentration. The micelle size was measured by dynamic light scattering and transmission electron microscopy. Also, the behaviour of the copolymer was studied in water/dioxane solutions by following the changes of scattered light intensity with the addition of water to the system. Critical water content (CWC) of the studied systems decreased as the initial PS-b-PGL concentration in dioxane increased. This process was accompanied by a decrease in the size of aggregate formed. For a given initial copolymer concentration, the size of copolymer aggregates decreased linearly with increasing the length of the PGL block
Characterisation of Terrain Variations of an Underwater Ancient Town in Qiandao Lake
Authors: Yang Fanlin , Xu Fangzheng , Zhang Kai , Bu Xianhai , Hu Hao , Anokye Michael
Published: January 2020

The underwater ancient town of Chunan is of great importance in archaeology and tourism. Hence, the efficient mapping and monitoring of the topographical changes in this town are essential. An attractive choice for the efficient mapping of underwater archaeology is the multibeam echo sounder system (MBES). The MBES has several advantages including noncontact survey, high precision, and low cost. In this study, the topographical changes of the ancient town under Qiandao Lake were quantitatively assessed on the basis of time-series MBES data collected in 2002 and 2015. First, the iterative closest point (ICP) algorithm was applied to eliminate the coordinate deviations between two point sets. Second, the robust estimation method was used to analyse the characterisations of the terrain variations of the town on the basis of the differences between the two matched point sets. Obvious topographical changes ranging from −0.89 m to 0.88 m were observed in a number of local areas in the town. On the global scale, the mean absolute value of the depth change in the town was merely 0.12 m, which indicated a weak global deformation pattern. The experiment proved the effectiveness of applying MBES data to analyse the deformation of the ancient town. The results are beneficial to the study of underwater ancient towns and the development of protection strategies.
Towards Local Forms of Sprawl: A Brief Reflection on Mediterranean Urbanization
Authors: Egidi Gianluca , Cividino Sirio , Vinci Sabato , Sateriano Adele , Salvia Rosanna
Published: January 2020

Urban sprawl is a complex phenomenon that requires a comprehensive reflection on the most significant patterns and underlying processes. While the “sprawl” notion parallels hegemonic concepts such as economic competitiveness, social cohesion, and polycentric development, an integrated analysis of sprawl patterns and processes in paradigmatic socioeconomic contexts is increasingly required to reconcile different disciplinary visions, contributing to a holistic interpretation of metropolitan change. At the same time, sprawl is an increasingly evident product of local socioeconomic contexts all over the world. A comprehensive investigation of multifaceted, form–function relationships underlying sprawl—based on a quali-quantitative analysis of representative cases—is a crucial pre-requisite of both monitoring and policy actions at multiple spatial scales, from urban/regional to national/continental levels. The present contribution proposes a contextualization of the sprawl notion in Southern Europe—a socioeconomic context characterized by compact and continuous urbanization for a long time. An integrated approach based on a visual analysis of urban and peri-urban landscapes—integrated with an extended literature survey—allows for a definition of a specific sprawl model in Southern Europe, sharing some features with the United States ideal type of sprawl and showing peculiarities with respect to common models of urban dispersion typical of Northern and Western Europe. Policies aimed at containing urban dispersion may definitely benefit from a local-based definition of sprawl, considering the specificity of form–function relationships and the underlying socioeconomic context.
The Impact of the Freight Transport Modal Shift Policy on China’s Carbon Emissions Reduction
Authors: Chen Shuling , Wu Jianhong , Zong Yueqi
Published: January 2020

How to reduce the negative transport externalities, especially its carbon emissions, without having significant negative influence on economic and social development is the key for sustainable development in China. This paper explores the impacts of China’s recent modal shift policy on carbon emissions, summaries experience from China, and points out future development directions. The paper first compares the different energy consumption and carbon emissions between the road freight transport and the railways in China, and then has a scenarios analysis on China’s energy consumption and carbon emissions of the transport sector in 2025. The latest progress and major problems of modal shift policy in China are presented, and a methodology to address this problem is also proposed. Based on the methodology, we compare the benefits and costs brought by modal shift policy in the case of Ordos, Inner Mongolia. Based on the results, principles and suggestions on how to design and implement more efficient modal shift policy are proposed. We find that road transport is the most polluting mode among various modes of transport, and the railway transport has the least carbon emissions. Furthermore, the modal shift policy plays a positive role in carbon emissions, but the costs caused by the policy are higher than the benefits at some circumstances. Moreover, to achieve the sustainable modal shift policy by relying on the feasible market mechanism, together with scientific and effective regulation, instead of “one size for all” administrative policy, are likely the way forward.
Partial Acidulation of Rock Phosphate for Increased Productivity in Organic and Smallholder Farming
Authors: Cicek Harun , Bhullar Gurbir S. , Mandloi Lokendra S. , Andres Christian , Riar Amritbir S.
Published: January 2020

There is a need to investigate and identify locally available organic substrates with acidifying potential, which can be used as an additive in rock phosphate (RP)-organic material composting mixtures. This paper reviews attempts to increase P availability in the context of smallholder, low-input and organic farming, and presents a case study from Central India that used a participatory approach to address P deficiency issues in cotton-based organic systems. Study was conducted from 2010 to 2014 through 61 on-farm trials and investigated the agronomic effectiveness of buttermilk-acidulated RP compost. The application of buttermilk-acidulated RP manure resulted in higher yields of cotton in all field trials and higher yields of soybean in all but one field trials. While on majority of the farms (18 out of 28), wheat yields increased with the application of buttermilk-acidulated RP compost, a quarter of the field trials (7 out of 28) exhibited yields lower than farmers’ practices. The study showed that it was possible to develop a locally adoptable solution to an agronomic constraint using locally available resources including the indigenous knowhow. Buttermilk proved to be an effective acidulating agent that can be added to RP-amended compost.
Sustainable Urban Community Development: A Case Study from the Perspective of Self-Governance and Public Participation
Authors: Fu Yang , Ma Weihong
Published: January 2020

(1) Background: There is a global trend to stimulate sustainable urbanization by updating the hardware of the built environment with green technologies. However, simply greening the city hardware does not ensure a sustainable urban system. In reality, urban communities, as cells of the city, play a crucial role in the sustainable development of the entire city. (2) Methods: This paper conducts a case study by investigating a community in Taipei with semi-structured interviews and other first-hand data. It examines how self-organization, voluntary groups, and the public participation of community members has successfully institutionalized a governing system for the sustainable development of communities; (3) Results: This paper identifies the major actors and mechanisms underpinning the sustainable development of urban communities with a case study in Taipei. The establishment of this more cost-effective form of community governance will possibly provide more benefits to community members; (4) Conclusions: This case study will shed light on the sustainable development of urban community in many other cities, offering possible pathways and epitome for self-organization of urban community in the coming era. Its cost-effective institutional design contributes greatly to sustainable community development, partly solving the current failure to promote urban sustainability.
Mineralization Patterns of Maize Straw in Fluvio-Aquatic Soil as Determined by Isotopic Traces
Authors: Zhu Lixia , Chen Jutian , Li Lili , Zhang Fuli , Liu Tianxue
Published: January 2020

The mineralization of plant residues results in changes in soil C and N. However, it is difficult to determine the origins of C and N from either soil organic matter mineralization or residue decomposition using traditional methods. An incubation experiment containing two treatments (blank soil (BS) and soil with 6% maize straw (MS)) was conducted to assess the contributions of maize straw to gas emissions, and to soil organic carbon (SOC) and total nitrogen (TN) using isotopic tracers. About 11.5% of maize straw C was sequestered in soil, the cumulative amount of C emitted from MS was 2.5-fold higher than that in BS treatment. A positive priming effect of maize straw on native SOC in the first 14 days was observed, and then became negative, indicating the potential for a positive balance of SOC storage. Cumulative N2O emissions in MS markedly decreased by 22.4% compared with BS, and the loss of N via N2O in MS was approximately 3.3%. Maize straw significantly increased soil TN and contributed 15.8% to TN at day 120. Our study clearly demonstrated that the different dynamics of 13C and 15N in the soils and gases indicated differences of maize straw C and N during decomposition. Maize straw C preferred to contribute to CO2 emissions, while maize straw N contributed more to soil TN.
Research on Collaborative Planning and Symmetric Scheduling for Parallel Shipbuilding Projects in the Open Distributed Manufacturing Environment
Authors: Mao Xuezhang , Li Jinghua , Guo Hui , Wu Xiaoyuan
Published: January 2020

In the current distributed manufacturing environment, more extensive enterprise cooperation is an effective means for shipbuilding companies to increase the competitiveness. However, considering the project scale and the uneven production capacity between the collaborative enterprises, a key issue for shipbuilding companies is to effectively combine the product-oriented project tasks and the specialized production-oriented plants. Due to information privatization, the decision-making process of project planning and scheduling is distributed and symmetric. Existing project scheduling methods and collaboration mechanisms in the shipbuilding industry are somehow inefficient. The aim of the research is to provide an assistant decision-making method to support effective task dispatching and multi-party cooperation for better utilization of the distributed resources and to help project managers control the shipbuilding process. The article initially establishes an agent-based complex shipbuilding project collaborative planning and symmetric scheduling framework, simulating the distributed collaborative decision-making process and bridging the multi-project planning with the individual project scheduling in much detail, which fills the research gap. A negotiation method based on iterative combination auction (ICA) is further proposed to solve the integration problem of project planning and task scheduling, and an illustrative example is conducted to demonstrate the effectiveness and rationality of the methods. Finally, an application case using a prototype system on shipbuilding projects collaborative planning and scheduling will be reported as a result.
A 12-bit 30 MS/s Successive Approximation-Register Analog-to-Digital Converter with Foreground Digital Calibration Algorithm
Authors: Li Shouping , Guo Yang , Chen Jianjun , Liang Bin
Published: January 2020

This paper presents a foreground digital calibration algorithm based on a dynamic comparator that aims to reduce comparator offset and capacitor mismatch, as well as improve the performance of the successive approximation analog-to-digital converter (SARADC). The dynamic comparator is designed with two preamplifiers and one latch to facilitate high speed, high precision, and low noise. The foreground digital calibration algorithm provides high speed with minimal area consumption. This design is implemented on a 12-bit 30 MS/s SARADC with a standard 0.13 μm Complementary Metal Oxide Semiconductor (CMOS) process. The simulation Nyquist 68.56 dB signal-to-noise-and-distortion ratio (SNDR) and 84.45 dBc spurious free dynamic range (SFDR) at 30 MS/s, differential nonlinearity (DNL) and integral nonlinearity (INL) are within 0.64 Least Significant Bits (LSB) and 1.3 LSB, respectively. The ADC achieves an effective number of bits (ENOB) of 11.08 and a figure-of-merit (FoM) of 39.45 fJ/conv.-step.
Characterization of Ebola Virus Disease (EVD) in Rhesus Monkeys for Development of EVD Therapeutics
Authors: Warren Travis , Zumbrun Elizabeth , Weidner Jessica M. , Gomba Laura , Rossi Franco , Bannister Roy , Tarrant Jacqueline , Reed Matthew , Lee Eric , Raymond Jo Lynne , Wells Jay , Shamblin Joshua , Wetzel Kelly , Donnelly Ginger , Van Tongeren Sean , Lackemeyer Nicole , Steffens Jesse , Kimmel Adrienne , Garvey Carly , Bloomfield Holly , Blair Christiana , Singh Bali , Bavari Sina , Cihlar Tomas , Porter Danielle
Published: January 2020

Recent Ebola virus (EBOV) outbreaks in West Africa and the Democratic Republic of the Congo have highlighted the urgent need for approval of medical countermeasures for treatment and prevention of EBOV disease (EVD). Until recently, when successes were achieved in characterizing the efficacy of multiple experimental EVD therapeutics in humans, the only feasible way to obtain data regarding potential clinical benefits of candidate therapeutics was by conducting well-controlled animal studies. Nonclinical studies are likely to continue to be important tools for screening and development of new candidates with improved pharmacological properties. Here, we describe a natural history study to characterize the time course and order of progression of the disease manifestations of EVD in rhesus monkeys. In 12 rhesus monkeys exposed by the intramuscular route to 1000 plaque-forming units of EBOV, multiple endpoints were monitored for 28 days following exposure. The disease progressed rapidly with mortality events occurring 7–10 days after exposure. Key disease manifestations observed consistently across the infected animals included, but were not limited to, viremia, fever, systemic inflammation, coagulopathy, lymphocytolysis, renal tubular necrosis with mineralization, and hepatocellular degeneration and necrosis.
Effect of Water Deficit on Morphoagronomic and Physiological Traits of Common Bean Genotypes with Contrasting Drought Tolerance
Authors: Godoy Androcioli Leonardo , Mariani Zeffa Douglas , Soares Alves Daniel , Pires Tomaz Juarez , Moda-Cirino Vânia
Published: January 2020

Water deficit is considered one of the most limiting factors of the common bean. Understanding the adaptation mechanisms of the crop to this stress is fundamental for the development of drought-tolerant cultivars. In this sense, the objective of this study was to analyze the influence of water deficit on physiological and morphoagronomic traits of common bean genotypes with contrasting drought tolerance, aiming to identify mechanisms associated with tolerance to water deficit. The experiment was carried out in a greenhouse, arranged in a randomized complete block 4 × 2 factorial design, consisting of four common bean genotypes under two water regimes (with and without water stress), with six replications. The morphoagronomic and physiological traits of four cultivars, two drought-tolerant (IAPAR 81 and BAT 477) and two drought-sensitive (IAC Tybatã and BRS Pontal), were measured for 0, 4, 8, and 12 days, under water deficit, initiated in the phenological stage R5. Water-deficit induced physiological changes in the plants, altering the evaluated morphoagronomic traits. The drought tolerance of cultivar BAT 477 is not only a direct result of the low influence of water deficit on its yield components, but also a consequence of the participation of multiple adaptive physiological mechanisms, such as higher intrinsic water use efficiency, net photosynthesis rate, transpiration, carboxylation efficiency, stomatal conductance, and intracellular concentration of CO2 under water deficit conditions. On the other hand, cultivar IAPAR 81 can be considered drought-tolerant for short water-deficit periods only, since after the eighth day of water deficit, the physiological activities decline drastically.
Water Markets in the Western United States: Trends and Opportunities
Authors: Schwabe Kurt , Nemati Mehdi , Landry Clay , Zimmerman Grant
Published: January 2020

Efforts to address water scarcity have traditionally relied on changing the spatial and temporal availability of water through water importation, storage, and conveyance. More recently, water managers have invested heavily in improving water use efficiency and conservation. Yet as new supply options become harder to find and/or appropriate, and demand hardens, society must consider other options to, if not reduce scarcity, minimize the impacts of such scarcity. This paper explores the role water markets are playing in addressing water scarcity in the American southwest: a water-limited arid and semi-arid region characterized by significant population growth rates relative to the rest of the US. Focusing on three representative southwestern states—Arizona, California, and Texas—we begin by highlighting how trends in water supply allocations from different water sources (e.g., surface water, groundwater, and wastewater) and water demand by different water users (e.g., agricultural, municipal, and environmental) have changed over time within each state. We then present recent data that shows how water trading has changed over time—in terms of value and volume—both at state level and sector level aggregates. We end with a discussion regarding some institutional adjustments that are necessary for water markets to achieve their potential in helping society address water scarcity.
Physical Model Study on Discharge over a Dam Due to Landslide Generated Waves
Authors: Tessema Netsanet , Sigtryggsdóttir Fjóla , Lia Leif , Jabir Asie
Published: January 2020

Impulse waves generated by landslides falling into reservoirs may lead to overtopping of a dam and, in turn, to flooding of the downstream area. In the case of an embankment dam, the overtopping may lead to erosion of the downstream slope, ultimately resulting in breaching and complete failure with consequent further hazardous release of water to the downstream area. This research deals with the overtopping process of a dam due to landslide generated waves in a three-dimensional (3D) physical scale model setup. Experiments have been conducted with varying the slide, reservoir, and dam parameters. The primary focus is on investigating the feasibility of employing the steady state weir equation in order to predict the overtopping discharge over a dam crest due to landslide generated waves. Calibration and validation of the coefficient of discharge values for the different dam section are conducted for the specified model setup. Accordingly, a two-step calculation procedure is presented for predicting the overtopping discharge based on the maximum overtopping depth values. Hence, for the fixed setup, which includes a constant slope angle of the landslide surface, a predictive equation for maximum overtopping depth is proposed, based on slide volume, slide release height, still water depth, upstream dam slope angle, and dam height. The relative slide volume and relative still water depth both seem to have a significant effect on the relative overtopping depth.
Direitos trabalhistas e dignidade da pessoa humana: uma perspectiva frente ao sistema interamericano de direitos humanos
Authors: Da Silveira Daniel Barile , Martins Pirolo Bruno Henrique
Published: January 2020

O presente artigo objetivou contextualizar conceitos de direitos humanos, fundamentais e laborais frente ao Sistema Interamericano de Direitos Humanos – SIDH. A intenção foi demonstrar que o âmbito do trabalho integra direitos basilares do ser humano e que os casos (assim chamados pelo próprio SIDH) que envolvam desrespeito a direitos laborais também possuem legitimidade para serem levados ao crivo do Comitê Interamericano de Direitos humanos – CIDH. Na atual sociedade multiglobalizada e dinâmica, novas perspectivas são introduzidas ao contexto das relações laborais a todo momento. Assim, a possibilidade de utilização de mais mecanismos de fiscalização quanto à garantia de direitos mínimos já consolidados é de grande valia. A pesquisa utilizou as metodologias dedutiva e histórico-bibliográfica para perceber a contextualização dos direitos mencionados, a qual é caminho natural da própria evolução de valores na relação trabalhista, e a possibilidade de garantia de direitos trabalhistas pelo SIDH, acarretando maior segurança aos empregados e empregadores, com reflexos positivos em toda sociedade.
A recomendação pelo Ministério Público como instrumento de provocação do controle preventivo de constitucionalidade
Authors: Novais de Paula Eduardo Loula
Published: January 2020

Este artigo busca analisar a possibilidade de o Ministério Público adotar novos comportamentos diante de um projeto de lei inconstitucional ou ilegal. Nesse sentido, em conformidade com a necessidade de se privilegiar uma atuação extrajudicial e resolutiva, afinada com os ditames constitucionais, se analisará a possibilidade de se conceder uma nova função para o instrumento extrajudicial da recomendação administrativa ministerial, à luz dos novos paradigmas do Ministério Público, que exigem uma instituição cada vez mais voltada para a resolução extrajudicial dos conﬂitos da sociedade pós-moderna. A metodologia seguida ao longo do presente artigo foi qualitativa, baseada no levantamento bibliográfco sobre o tema e a pesquisa descritiva e teórica, haja vista tratar-se de pesquisa eminentemente jurídica, com o fm de interpretar os fatos e as normas jurídicas que regem a temática doravante analisada e, partindo do posicionamento doutrinário e normativo existente, defender uma nova função para institutos consagrados no ordenamento jurídico pátrio.
A adoção unilateral é irrevogável? Uma análise crítica do acórdão proferido no REsp 1.545.959/SC: discricionariedade judicial e os limites da legalidade
Authors: Cavallazzi Júlia Wendhausen
Published: January 2020

O artigo se propõe a analisar criticamente o acórdão proferido pelo Superior Tribunal de Justiça no REsp 1.545.959/SC, julgado em 6 de junho de 2017, em que a referida Corte desconstituiu sentença transitada em julgado que deferiu adoção unilateral do enteado ao padrasto, a despeito da vedação expressa contida no art. 39, § 1o, do Estatuto da Criança e do Adolescente. A partir da reconstrução lógica dos fundamentos que conduziram à conclusão do acórdão, são problematizados: o caráter de regra da norma contida no art. 43 da Lei n. 8.069/90, a partir da distinção entre princípios e regras na teoria de Ronald Dworkin; o ativismo judicial à brasileira e a utilização indiscriminada dos princípios pelo intérprete como panaceia para decidir conforme a própria consciência. O objetivo é verificar se os fundamentos da decisão resistem a um exame crítico a partir de critérios de integridade e coerência.
Fiscalização de contratos e a atuação preventiva na tutela da moralidade administrativa
Authors: Naspolini Samuel DalFarra , Ganzo Sandra Regina Bogisch
Published: January 2020

O presente artigo aborda as atividades de fiscalização dos contratos administrativos, obrigação legal imposta à Administração Pública pela Lei de Licitações e relevante instrumento para prevenção de ilícitos administrativos. As atribuições do fiscal tocam diretamente à satisfação do interesse público, razão de ser do contrato administrativo, e perpassam desde a execução da avença até eventual penalização do contratado. Dessa forma, fortalecer os mecanismos administrativos de fiscalização do contrato implica reforçar o papel do Ministério Público na defesa do patrimônio coletivo.
O pacto federativo e a democracia nas constituições estaduais
Authors: Muniz Alexandre Carrinho
Published: January 2020

A democracia não é conceito fechado ou estanque, e sua fonte normativa não advém apenas da Constituição da República. Embora, no Brasil, o pacto federativo, nos moldes em que se encontra, imponha limites aos Estados-membros, é possível que, em suas respectivas Constituições, ressaltando a máxima de sua autonomia, sejam instituídos instrumentos que permitam uma maior participação popular e direitos e garantias fundamentais ao exercício da cidadania, ainda que não previstos na Carta Republicana. Democracia, assim, não é só o que está na Constituição da República, mas também nas Constituições estaduais, em especial, nos pontos em que privilegiam uma maior participação popular, seja na iniciativa legislativa, seja na tomada de decisões. Para tanto, a discussão proposta no presente artigo é analisar o pacto federativo, a repartição de competências aos Estados-membros, e a possibilidade de ampliação da democracia por meio das Constituições estaduais. Seu objetivo geral é analisar não apenas o alcance do pacto federativo na Constituição da República e na repartição de competências entre os entes federados, mas também a (im)possibilidade de os Estados-membros inovarem em suas Constituições estaduais e obterem a ampliação da democracia por meio de instrumentos jurídico-políticos, direitos e garantias fundamentais. Para elaboração do estudo, foi utilizado o método indutivo, com as técnicas doreferente, das categorias operacionais, da pesquisa bibliográfca e do fichamento.
O emprego de medidas executivas atípicas no âmbito da improbidade administrativa
Authors: Di Sena Junior Roberto
Published: January 2020

As medidas executivas atípicas foram significativamente ampliadas no contexto do novo Código de Processo Civil, o qual autoriza sua aplicação inclusive no âmbito das obrigações de pagar quantia certa. A previsão legal contida no art. 139, IV, busca garantir maior efetividade às decisões judiciais e contribuir para que elas, de fato, eliminem as insatisfações sociais através da aplicação do direito. O tema tem sido objeto de intensos debates, pois o legislador de 2015 não estabeleceu critérios nem limites ao chamado “poder geral de efetivação”. O presente artigo consiste numa tentativa de identificação desses limites, bem como na análise da possibilidade de aplicação de medidas executivas atípicas no âmbito da tutela da moralidade administrativa.
Kredi ve Kredi İşlemlerinin Hukuki Açıdan Değerlendirilmesi
Authors: ÇAĞIRGAN TUNCER Senar , ULUSOY Yasin
Published: January 2020

En basit tanımıyla satın
alma gücünün, belli bir süre sonra ödenmesi taahhüt edilerek, faiz karşılığında
bir başkasının kullanımına bırakılması olan kredi, günümüzde bankacılık
işlemleri içinde önemli bir yer teşkil etmektedir. Kredi; satın alma gücü
sağlamak amacıyla, maddi ya da maddi olmayan bir malın veya bir miktar para
yahut garanti sözleşmesi ve kefalette söz konusu olduğu gibi risk için
sorumluluk yüklenilmesini kapsar. Bu itibarla kredi türlerini en genel
çerçevesi ile bankalar tarafından, nakdi bir ödeme yapılarak kredi alana satın
alma gücü sağlayan nakdî krediler ile nakdi bir ödemede bulunmaksızın bir
riskin gerçekleşmesi durumunda sorumluluğun üstlenilmesi şeklinde gayri nakdi
krediler olmak üzere ikiye ayırabiliriz. Bu ayırım çerçevesinde kredi
türlerinin hukuki niteliği ve uygulanacak hükümler farklılaşmaktadır. Banka ile
bir gerçek veya tüzel kişi arasında kredi ilişkisi tek bir kredinin açılmasına
ilişkin kredi sözleşmesi veya birden çok kredinin açılmasını içine alan kredi
açma sözleşmesinin imzalanması suretiyle doğmaktadır. Kredi sözleşmesin veya
kredi açma sözleşmesinin içeriği kredi türüne göre farklılık gösterir. Bunun
yanında kredi veya kredi açma sözleşmesi ile kurulan kredi ilişkisinde,
kredinin kullanma şekli, ödemenin ne şekilde gerçekleşeceği gibi hususlar
açısından, kredinin işleyeceği hesabın türü de önem taşımaktadır.
Piramidin Tabanında Saklı Hazine Ters İnovasyon Hakkında Bir Tarama
Authors: BARDAKCI Ahmet , GÜRKAYNAK GÜRBÜZER Şeyda , AKYILDIZ Bahar
Published: January 2020

Çokuluslu şirketler yıllarca fakir ülkeleri farklı hatalı varsayımlara bağlı olarak ihmal ettiler. Fakirler ülkelerin yeterince cazip olmadığı görüşünden kurtulamadılar. 2000’li yıllarda özellikle General Elektrik (GE) Sağlık bölümünün Hindistan’da ve Çin’de başlattığı projelerin çıktıları Prof. Vijay Govindarajan’ın dikkatini çekti. Bu örnekler Uluslararası Mamul Hayat Eğrisi teorisi ile çelişiyor hatta aksini işaret ediyordu. Bu makale özellikle öğrencilerin kavramla tanışmalarına yardımcı olmak için ters inovasyon kuramını literatürdeki örneklerle ele almaktadır.
Synergy in a Team – Quality Analysis of Conditions
Authors: Jasińska Monika
Published: January 2020

Synergy is a powerful tool that emerges when the social potential is improved and high activity is achieved. This is a feature of well-functioning and continuously learning teams. The aim of the study is to examine circumstances that may favour synergy in team work. Teams functioning in a company that is typical for a learning organisation were selected to conduct analysis in the case study. In order to collect the data, the author applied grounded theory and surveys along with descriptive and analytical methods. The study proved that team synergy conditions are the quality of cooperative relations, entrepreneurial potential and measurable effects of joint action.
The Presence of Mass Media Representatives During the General Proceedings in the Light of Changes Introduced by the Act of 10 June 2016
Authors: Skawińska Joanna
Published: January 2020

Pursuant to the Act of 10 June 2016 amending the Penal Procedure Code, the Medical Profession Act and the Act on the Patient's Rights and the Patient Ombudsman, the conditions regarding granting permission to mass media representatives to participate in proceedings have been amended. According to the previous provisions of Article 357 of the Penal Procedure Code, the court could facultatively allow mass media representatives to record the general proceedings' course if the premises stipulated in paragraph one of that regulation were met cumulatively. Simultaneously, the court was entitled to determine the conditions which it made the issue of such a permit conditional on. Amending Article 357 of the Penal Procedure Code, the legislators
revoked the limitations previously in force. This means that at present – following the regulations change – the court is obliged to allow mass media representatives to record images and sound during the proceedings, using any devices, provided this is public. Any organisational aspects related to the general proceedings shall be decided by the court. The court does it by way of a decision not entitled to any appeal. Recording the proceedings course helps to inform the general public about the proceedings as a component of its public nature. Mass media present solely a chosen part of the proceedings, its excerpt which does not necessarily reflect the proceedings essence.
viajeros mexicanos del siglo XIX y sus musulmanes
Authors: Tolentino García Adrián
Published: January 2020

Este escrito estudia los viajeros mexicanos que visitaron el Medio Oriente durante el siglo XIX. Se analizará cómo es que estos mexicanos interpretaron a los musulmanes y el Islam con que inevitablemente se cruzaron durante cada viaje. Se busca explicar por qué los mexicanos interpretaron el Islam de una forma determinada. Para lograrlo, se retoma el tránsito de la herencia hispánica de México a la Modernidad republicana. Este análisis presenta, así, las diferencias de cada acto de viajar, e indaga en la peculiaridad que modifica las impresiones que se vierten sobre los musulmanes.
(DOCUMENTO) Talamantes y su proyecto para la independencia de México y la creación de una comunidad de reinos hispánicos
Authors: Pampillo Baliño Juan Pablo
Published: January 2020

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PERLINDUNGAN HUKUM TERHADAP ISTERI SEBAGAI KORBAN KEKERASAN DALAM RUMAH TANGGA
Authors: Sulastri Sulastri , - Satino , Yuli W Yuliana
Published: January 2020

Istri yang menjadi korban kekerasan dalam rumah tangga harus mendapatkan perlindungan hukum sesuai dengan amanat Undang-Undang Nomor 23 tahun 2004 tentang Penghapusan Kekerasan Dalam Rumah Tangga. Pasal 10 Undang-Undnag Nomor 23 Tahun 2004 tentang Penghapusan Kekerasan Dalam Rumah Tangga menyatakan bahwa korban kekerasan dalam rumah tangga berhak mendapatkan perlindungan dari pihak keluarga, kepolisian, kejaksaan, pengadilan,advokat, lembaga sosial, atau pihak lainnya baik sementara maupun berdasarkan penetapan perintah perlindungan dari pengadilan,pelayanan kesehatan sesuai dengan kebutuhan medis,penanganan secara khusus berkaitan dengan kerahasiaan korban,pendampingan oleh pekerja sosial dan bantuan hukum pada setiap tingkat proses pemeriksaan sesuai dengan ketentuan peraturan perundang-undangan dan pelayanan bimbingan rohani.Metode penelitian yang dilakukan dalam penelitian  ini adalah dengan menggunakan metode penelitian kualitatif melalui penelitian hukum normatif. Penelitian normatif yang bersifat kualitatif adalah penelitian yang mengacu pada norma hukum yang terdapat dalam peraturan perundang-undangan dan putusan pengadilan serta norma-norma yang hidup dan berkembang dalam masyarakat, khususnya yang dalam hal ini berkaitan dengan pokok permasalahan yang akan dibahas dalam penelitian  ini.
A systematic approach to understanding the essence of the post­industrial and intellectual economy
Authors: Parkhomenko V. D. , Parkhomenko O. V. , Seki S.
Published: January 2020

Economic science pays much attention to the research of the essence of post-industrial intellectual economy today. Many theoretical approaches to understanding the development process of post-industrial society have been formed in the modern world, but the final concept of modern intellectual socio-economic development does not yet exist. The basis of the formation of a post-industrial and intellectual economy is information, knowledge and creativity — these are modern types of resources that different from monetary, natural, labor and technical resources and which become the basis of the “economy of knowledge”. The basic systems of functioning of the intellectual economy are determined, which are interconnected and important. An intelligent post-industrial economy is formed considering internal systemic relationships between different types of activities at the societal level, human, intellectual capital, innovation activity, intellectual property, at the staffing level and the use of synergy and creativity. Such interaction is considered as a single complex and open system with a significant number of subsystems. The unifying idea of a complex system is a statement based on the use of information and knowledge. Both of each system individually and interconnections have an internal unity of contradictions. This is the unity of contradictions that is a “delta” of progress. The unifying elements of interacting systems are human and goal. All groups of components of the intellectual and post-industrial economy are united by a single object of activity (creative process, knowledge) and have various subjects of activity. For this reason, there is a need for comprehensive research, consider the presence of a single object, as well as various subjects of activity with their own characteristics of their functioning.
Innovative entrepreneurship as an effective mechanism of technology transfer in Israel
Authors: L.V. Volosheniuk , N.I. Hornostai , Mykhalchenkova O.E.
Published: January 2020

In the article, the authors revealed how the transfer of technology from the university to business is carried out and the “gap at the development level” is bridged in Israel. The policy, models, and principles in the field of technology transfer, mechanisms of stimulating the technology transfer by researchers to business are analyzed, it’s studied how the entrepreneurial initiative of the Israeli research institutions is implemented. There are several ways to support technology transfer. One of them is targeted programs aimed at stimulating the interaction of the scientific community and business, carried out on the initiative of the government, represented by the Office of the Chief Scientist and with his financial support. Another mechanism for encouraging the technology transfer by researchers to business is tax exemption. In most cases, an entrepreneurial initiative in the field of technology can be implemented without the full involvement of the inventor. In such cases, the licensee takes charge of the process of developing the technology and product. Models of researcher participation in the implementation of entrepreneurial initiative in the field of technology, as a rule, are implemented in one of the following ways: a) issuing a license for innovative technology to a company engaged in the relevant industry; b) licensing of a startup, which is created due to the invention of technology. In Israel, there are three sectors of R&D, each of which operates independently of one another and forms its own policy in the field of technology transfer by public research institutes to business. Successful technology transfer mechanisms have been created in the scientific environment that serve the interests of universities and society and do not require intervention from the regulator. The commercial sector works for the benefit of business with the financial and other support of the regulator, represented by the Chief Scientist at the Ministry of Commerce.
Karakteristik dan Kualitas Hidup Pasien Penyakit Parkinson dengan Probabel Gangguan Perilaku Tidur Fase Gerak Mata Cepat di Manado
Authors: Koleangan Grisheila M. , Mawuntu Arthur H. P. , Kembuan Mieke A. H. M.
Published: January 2020

Abstract: Rapid eye movement sleep behavior disorder (RBD) often occurs in patients with Parkinson's disease (PD) and it could reduce their quality of life (QoL). This study was aimed to obtain the characteristics and QoL of PD patients with pRBD in Manado. This was a descriptive study with a cross-sectional design. Subjects were PD patients with pRBD at Prof. Dr. R. D. Kandou Hospital from October to November 2019. The QoL was measured by using the SF-36 QoL questionnaire. The results obtained 48 eligible subjects. Male patients were more common than females (52.1% vs 47.9%). Most of the subjects were 60-69 years (54.1%), had senior high school and junior high school education (each of 29.1%), and unemployed (41.7%). Moreover, 62.5% of patients had been diagnosed as PD since 1-5 years ago. The mean score of the physical and mental component of the subjects were 46.5 and 60.8 subsequently. In conclusion, the majority of patients with Parkinson's disease and pRBD were 60-69 years, senior or junior high school educated, unemployed, and had been diagnosed as PD since 1-5 years ago. Their quality of life in physical component was below norm-based score but in mental component was still good.Keywords: Parkinson's disease, probable RBD, quality of life, SF-36 Abstrak: Gangguan perilaku tidur fase gerak mata cepat (rapid eye movement sleep behaviour disorder/RBD) sering terjadi pada pasien penyakit Parkinson (PD) yang mungkin menurunkan kualitas hidup mereka. Penelitian ini bertujuan untuk mengetahui karakteristik dan kualitas hidup pasien PD dengan probabel RBD (pRBD) di Manado. Jenis penelitian ialah deskriptif dengan desain potong lintang terhadap pasien PD dengan pRBD yang datang ke RSUP Prof. Dr. R. D. Kandou Manado bulan Oktober-November 2019. Kualitas hidup diukur menggu-nakan kuesioner kualitas hidup SF-36. Hasil penelitian mendapatkan 48 pasien yang meme-nuhi kriteria penelitian. Pasien berjenis kelamin laki-laki lebih banyak daripada perempuan (52,1% vs 47,9%). Sebagian besar pasien berada pada kelompok usia 60-69 tahun (54,1%), tingkat pendidikan terakhir SMA/Sederajat dan SMP sama banyak (29,1%), dan tidak bekerja (41,7%). Sebanyak 62,5% subjek telah terdiagnosis PD sejak 1-5 tahun sebelumnya. Skor rerata komponen fisik dan komponen mental kualitas hidup SF-36 ialah 46,5 dan 60,8. Sim-pulan penelitian ini ialah mayoritas pasien penyakit Parkinson dengan pRBD berusia 60-69 tahun, pendidikan SMA/sederajat atau SMP, tidak bekerja, dan telah terdiagnosis PD sejak 1-5 tahun sebelumnya. Kualitas hidup pasien penyakit Parkinson dengan pRBD pada komponen fisik secara umum berada di bawah skor normatif tetapi komponen mental masih baik.Kata kunci: penyakit Parkinson, probabel RBD, kualitas hidup, SF-36