bluuebunny/crossref_metadata_2025 huggingface dataset:
Alcances Terapêuticos e Matriciais: Uma Experiência de Grupo de Saúde Mental na Atenção Básica
Authors: Cangussu Yanna Embiruçu Souza , Guedes Lidiane
Published: March 2022

INTRODUÇÃO: A saúde mental ganha um outro lugar no sistema de cuidado integral à saúde a partir do SUS. A Atenção Básica passa a integrar a RAPS desde a Portaria 3.088, de 23 de dezembro de 2011, tornando-se corresponsável por este cuidado. Na prática essa mudança ocorre de forma progressiva e encontra barreiras, principalmente quanto a formação dos profissionais e alguns estigmas enraizados. Diante disso, destaca-se a importância de ações que visem promover a saúde mental neste contexto. OBJETIVO: Refletir acerca dos desafios e potencialidades da AB frente as demandas de SM e do matriciamento entre os profissionais de saúde, através do relato da experiência de um grupo de cuidado em SM, sob o ponto de vista de uma psicóloga da Residência Multiprofissional de Saúde da Família (FESF-Fiocruz). MÉTODO: Trata-se de um relato de experiência, de caráter qualitativo, sobre um grupo de cuidado em SM realizado em uma USF em Lauro de Freitas (BA). RESULTADOS E DISCUSSÕES: O grupo foi desenvolvido de forma interdisciplinar e com participação social. Visou ser terapêutico, abrindo-se para a escuta e fortalecimento de vínculos, além de ser um espaço de matriciamento. CONSIDERAÇÕES FINAIS: A AB é um serviço fundamental na estruturação da RAPS, porém ainda está num processo de se reinventar neste papel. O grupo demonstra como pode ser um desafio ir além da lógica biomédica, se propor a superar estigmas, criar novas possibilidades de cuidado em saúde, e se permitir ser afetado pela experiência, mas também como pode ser transformador para a saúde mental e formação dos envolvidos
ARTISTIC TEXT AS A STATEMENT (ON EXAMPLE OF THE A.P. CHEKHOV STORY “WARD № 6”)
Authors: RAMAZANOVA Shalala, Shelale, Şelale
Published: March 2022

In our study, the most famous story of Anton Pavlovich Chekhov, who is known as the world-famous Russian and short story writer and is among the greatest writers in history, “Ward No. 6” is handled. In our article, the methodology of literary text analysis is explained, taking into account the internal dynamics of the construction of expressions and their inclusion in the chain of communication in the application of interactive teaching of the Russian language to Turkish students in a foreign language. Anton Pavlovich Chekhov's story "Ward No. 6" is accepted as a message that the reader is expected to respond to in the form of a call, criticism, evaluation, and sympathy. In our study, three types of expressions covering the text were used.
These are the monologue author's speech, the indirect speech of the characters, and the dialogical speech.
the author reveals the individuality of the topic of speech, his own style, worldview, the peripeteia of the plot of the works, with the author's speech, the different forms of expression of the characters' speech. In addition, in our study, through the role of landscape drawings, the year, the month, the day, the hour, the weather, as well as an action scene, are analyzed as a marker as well as the peripeteia of the plot of the work and an indicator of the emotional state of the characters. The subject of our study is the types of expressions in the story text as a communication tool between the characters, the author and the reader.
In our study, as a part of the interactive teaching of Russian, the text analysis of Anton Pavlovich Chekhov's story "Ward No. 6" conducted with Turkish students, taking into account all the difficulties of understanding a foreign language text, the strategy of reading and understanding Russian literary texts, the speech tools used as a complex expression and it was concluded that each reader should find his own individual answer.
RNA Extraction and RT-qPCR of Human Lung Organoids v1
Authors: Baumgardt Morris , Hülsemann Maren , Mieth Maren , Hippenstiel Stefan , C. Hocke Andreas , Hönzke Katja
Published: March 2022

This protocol describes the RNA extraction from human lung organoids followed by the perfomance of a RT-qPCR to quantify the amount of hostfactors of SARS-CoV-2. The protocol contains detailed steps for the lysis of human lung organoids, as wells as the RNA extraction followed by the reverse transcription into cDNA. In the next section the protocol describes in detail how to quantify the gene expression with the TaqMan gene expression kit and how to calculate the Ct values.
Lab protocol v1
Authors: Yoshimizu Rikuto
Published: March 2022

This study was conducted to investigate the incidence of lumbar degeneration findings and low back pain (LBP) in children and adolescent weightlifters using magnetic resonance imaging (MRI) and medical questionnaires over a 5-year period. Moreover, we aimed to reveal the temporal changes in the lumbar vertebrae caused by long-term weightlifting training during the growth period. The findings of this study may help to prevent irreversible injuries in children and adolescent athletes undergoing weightlifting training.
TSS, TXS, SDS Serial Extraction v1
Authors: Geertsma Haley
Published: March 2022

This protocol is used to serially extract protein from mouse brain tissue in increasingly stringent buffers.
[RETRACTED] Coral CBD GummiesReview v1
Authors: not provided yekyakesehua
Published: March 2022

[RETRACTED]

https://www.completefoods.co/diy/recipes/coral-cbd-gummies-review-where-to-buy
Electrical Stimulated Polyvinyl Alcohol-Borax-Graphene Hydrogel for Drug Releasing and Delivery
Authors:   Department of Biomedical Engineering University of Bridgeport, Batayneh Jafar M.
Published: March 2022

Polyvinyl Alcohol hydrogel has promising applications in numerous biomedical, biomaterial, and tissue engineering. However, it has poor conductive properties, restraining its development within huge fields such as bio-signals acquisition systems, thermal stability, and drug delivery. Adding Graphene as a nanofiller will produce PVA/Borax/Graphene nanocomposite hydrogel, which is an excellent procedure to significantly improve the conductive properties of PVA. The toxicity will not affect the nanocomposite while very well-dispersed graphene will significantly improve the thermal and conductivity stability of the nanocomposite. In this study, we investigated the performance of a newly prepared conductive hydrogel gel using the freezing/thawing method
Sorption of Copper Ions from the Nitric Acid Solution of Electrolytic Refining of Silver with Using Chelating Resin Axionit BPA
Authors:   JSC «Axion – Rare and Noble Metals», Aleynikov Sergey A.
Published: March 2022

The article considers a sorption method for extracting copper ions from a model nitric acid solution based on a solution of electrolytic refining of silver with using sorbents with bis-picolylamine functional groups: Dowex M-4195 and AXIONIT BPA. The possibility of extracting copper to residual concentrations in the solution of less than 10 mg/l is shown. The working capacity of both samples under batch conditions, as well as the dynamic exchange capacity and the full dynamic exchange capacity under dynamic сonditions (column test), are determined. The effect of the flow rate of the solution into the column on the kinetics of the sorption of copper ions on AXIONIT BPA is shown. The possibility of desorption of copper with a solution of 3 %, 5 % NH4OH was investigated, and a two-stage scheme of desorption of copper was tested: 5 % and 10 % with a solution of ammonium hydroxide
Clinical prognostic factors for fibrolamellar liver carcinoma
Authors: Antonova Elena Yu. , Moroz Ekaterina A , Podlyzny Daniil V. , Kudashkin Nikolai E. , Volkov Aleksandr Yu. , Dzhanyan Irina A. , Laktionov Konstantin K. , Breder Valery V.
Published: March 2022

BACKGROUND: Fibrolamellar liver carcinoma is a rare subtype of liver cancer with an unexplored etiology. There is no information about the choice of classification for fibrolamellar liver carcinoma (FLC) in the world literature, and data on the prognostic significance of clinical aspects in FLC are very contradictory and require further study.
AIM: To evaluate the practical significance of staging systems for operable hepatocellular cancer for fibrolamellar carcinoma (TNM/AJCC, BCLC) as a separate option, to study the influence of clinical aspects (disease stage, gender, age, size of tumor) of patients with FlC on the long-term results of their treatment.
MATERIALS AND METHODS: The retrospective study included 34 patients with FlC who underwent radical surgical treatment at the first stage at the Blokhin National Research Institute of Oncology of the Ministry of Health of the Russian Federation from 2005 to 2020.
RESULTS: When assessing the prevalence of the disease according to the TNM-8/AJCC system, a significant correlation between the FlC stage and the prognosis was revealed. It is proved that the greatest RFS was achieved in the group of stages IIIIIB, while the smallest RFS was achieved in the group with stage IVB (p=0.002; p=0.000). The highest OS was achieved in the group of stages IIIIIB, while the lowest OS was achieved in the group with stage IVB (p=0.050; p=0.000). The OV of patients with FlC was not dependent
CONCLUSIONS: The TNM-8/AJCC classification optimally predicts the results of surgical treatment of FlC. The use of the Barcelona staging system for this subtype of liver cancer is impractical. The size of the primary tumor, as part of the FlC staging system, turned out to be an independent prognostic factor. The age of the patient 20 years correlates with the deterioration of OV.
Heterotopic ossification as a side effect of the use of recombinant human bone morphogenetic proteins
Authors:   Kuvatov Republican Clinical Hospital, Ufa, Russian Federation, Mukhametov U.F. , Lyulin S.V. ,   Medical Center Carmel, Chelyabinsk, Russian Federation, Borzunov D.Yu. ,   Ural State Medical University, Ekaterinburg, Russian Federation, Gareev I.F. ,   Federal Center of Neurosurgery, Tyumen, Russian Federation, Beylerli O.A. ,   Bashkir State Medical University, Ufa, Russian Federation, Sufianov A.A. ,   Sechenov First Moscow State Medical University, Moscow, Russian Federation,   Bashkir State Medical University, Ufa, Russian Federation
Published: March 2022

Introduction Heterotopic ossification (HO), also known as myositis ossification, paraosteoarthropathy, or heterotopic calcification, among others, is a common pathological condition that refers to ectopic bone formation in soft tissues. Although the molecular mechanism of HO is not fully understood, it is believed that signaling of bone morphogenetic proteins (BMPs) plays a key role in the overall process of HO. Today, recombinant human BMP-2 (rhBMP-2) and recombinant human BMP-7 (rhBMP-7) have been already actively used in clinical practice in the treatment of bone defects. However, despite the positive sides of using rhBMPs, there are a number of side effects, one of which is HO. Purpose In this study, we demonstrate cases of HO following the use of rhBMPs in both clinical and preclinical studies and make an attempt to explain the relationship between the signaling pathways of BMPs and the HO process, as well as the possibilities of preventing and treating the HO process. Materials and methods PubMed, Embase, the Cochrane Database, and Google Scholar were comprehensively searched for original articles, literature reviews, case reports, and meta-analyses demonstrating a causal relationship between therapeutic rhBMPs and HO as a complication. Results This review analyzes the potential for therapeutic use of rhBMPs in neurosurgery and traumatology and orthopedics, demonstrated by both clinical and preclinical studies. In particular, the studies confirm that ectopic bone formation is one of the side effects following administration of rhBMPs. Moreover, the molecular mechanisms of the HO process were highlighted, and the possibilities of modern methods of prevention and treatment of HO were discussed. Conclusion According to the FDA safety database for rhBMPs, the rates of adverse effects related to HO range from 1 % to 10 %. However, to date, the clinical use of rhBMPs is justified, especially when there are no alternative substitutes for bone grafting.
Total elbow arthroplasty due to injuries
Authors:   Autonomous non-profit organization Central Clinical Hospital of St. Alexy Metropolitan of the Moscow, Moscow Diocese of the Russian Orthodox Church, Moscow, Russian Federation, Kalantyrskaya V.A. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation, Golubev I.O. ,   N.N. Priorov National Medical Research Center of Traumatology and Orthopaedics, Moscow, Russian Federation, Zarov A.Yu. ,   Autonomous non-profit organization Central Clinical Hospital of St. Alexy Metropolitan of the Moscow, Moscow Diocese of the Russian Orthodox Church, Moscow, Russian Federation, Egiazaryan K.A. ,   Pirogov Russian National Research Medical University, Moscow, Russian Federation
Published: March 2022

The aim of the study was to identify the features of total elbow arthroplasty in traumatic cases and their consequences in patients of different age groups and to conduct a comparative retrospective analysis of differentiated treatment tactics. Materials and Methods A retrospective analysis of the results of total elbow arthroplasty (TEА) in the period from 2009 to 2019 was carried out in 101 patients with injuries and severe consequences of elbow joint injuries, 56 (55.4 %) men and 45 (44.5 %) women among them in the average age of 48.5 ± 12.5 years. Three groups of patients were formed. Group I were 29 (28.7 %) subjects who underwent conservative treatment of fractures before TEА; the second group (II) of 52 (51.5 %) patients underwent TEА after ORIF, the third group of 20 (19.8) individuals (III) were patients who had primary TEА. We investigated pain (VAS), range of motion, tests with the DASH and MEPS scales, hand strength. Results One year later, there was a statistical difference in the results (p = 0.0213) between group III DASH = 7.3 ± 2.1) compared with groups I (DASH = 20.6 ± 3.3) and II (DASH = 18.4 ± 4.2); in group III, MEPS was excellent (90.7 ± 8.4), and in groups I (MEPS = 83.8 ± 7.4) and II (MEPS = 84.2 ± 5.6) good (p = 0. 0344). There were no differences in the dynamometry of hand strength and pain. Discussion Treatment of fractures of the elbow joint is a challenge that has several aspects. Conservative treatment results in high incidence of pronounced contractures, which affect the range of motion in the elbow joint after TEA; in severe damage to bone and cartilage, it is necessary to evaluate many factors in order to make the right choice between ORIF and primary TEА. New prosthetic technologies are needed to ensure good long-term functioning of the elbow prosthesis, especially in young patients. Conclusion To choose the treatment tactics in severe injuries of the elbow joint, it is necessary to consider not only the severity of the injury, but also the age of the patient and the quality of the bone, especially in elderly patients. Rejection to perform osteosynthesis in favor of primary total arthroplasty is aimed at maintaining the range of motion, improving the functional results and survival of the endoprosthesis.
Treatment of tibial wound consequences: further development of the Ilizarov technology
Authors:   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Lychagin A.V. , Gritsyuk A.A. ,   3 Central Military Clinical Hospital named after A.A. Vishnevsky, Moscow region, Krasnogorsk, p. Novy, Russian Federation, Korytin V.S. ,   I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation,   3 Central Military Clinical Hospital named after A.A. Vishnevsky, Moscow region, Krasnogorsk, p. Novy, Russian Federation
Published: March 2022

Introduction Severe open injuries and wounds of the tibia refer to the topical problem of traumatology due to the difficulties in the functional restoration of the segment when there is a bone and soft tissues defect. Material and method The treatment of 11 patients with soft tissue and tibial defects was analyzed. At the time of reconstruction, the age of male patients ranged from 20 to 52 years (mean age 34.2 ± 3.2 years). Gunshot wounds of tibia occurred in 7 injured and tibial injury was observed in 4 cases. Segmental defects of the tibia ranged from 6 cm to 18 cm, mean 12.6 ± 4.4 cm, myocutaneous defects ranged from 20 cm2 to 112 cm2, mean 74.4 ± 22.4 cm2. Results In seven cases, the wounds healed by primary intention, the signs of infection and marginal necrosis of the soft tissue component of the flap were observed in 4 (36.4 %) cases and were addressed conservatively (dressings and debridement), but in one case, necrosis was excised (on day 21) and autodermoplasty was performed using split skin graft. We had no problems with the transport (distraction) of bone regenerates, since the rib cage of the flaps protected the soft tissues and the vascular pedicle of the flap, despite the early start of distraction (mean period 7.3 ± 2.1 days) and the length of treatment, when averaged, was 163.2 ± 8.7 days. Support function was restored in all patients and the functional results were satisfactory. Discussion The combination of Ilizarov distraction osteogenesisand soft tissue reconstruction using free vascularized flap grafting makes it possible to invalidate the short-comings of both, i.e. to lighten up the bone transfer, to avoid damage to the scarred skin of the anterio-medial surface of tibia and to preserve the axial circulation of the graft. The inclusion of a rib fragment provided the required conditions for application the Ilizarov distraction method. The rib, not being a supportive bone tissue, protected the soft tissue component of the flap and its vascular pedicle from deformity and participated in the formation of callus. Conclusions Plastic filling in the extensive tibial defects using free vascularized myocutaneous flap with rib fragments and Ilizarov distraction osteogenesis provides favorable conditions for acute surgical intervention allowing to save the limb, restore the support ability and return the patients to work.
Experimental validation for the Achilles tendon reinforced with new techniques
Authors:   Samara State Medical University, Samara, Russian Federation, Kotelnikov G.P. , Kim Yu.D. ,   Samara State Medical University, Samara, Russian Federation, Shitikov D.S. ,   Samara State Medical University, Samara, Russian Federation, Knyazev N.A. ,   Samara State Medical University, Samara, Russian Federation, Likholatov N.E. ,   Samara State Medical University, Samara, Russian Federation
Published: March 2022

the effectiveness of new methods of the Achilles tendon reinforcement. Material and methods The experimental part of the work was performed in 3 stages using 60 biomannikins with intact Achilles tendon. A Krakow suture was used at stage 1 for a group of 20 tendons and a force that would result in rupture of the tendon was measured. Reinforcement was performed using the plantaris tendon (technical innovation offered at the Samara State Medical University) at the 2nd stage and the force required for the appearance of signs of rupture was subsequently measured. A portion of the peroneus longus tendon (RF patent No. 2616767) was used for reinforcement at the 3rd stage and the force measurement produced. Results The mean force required to rupture the Krakow suture applied to the tendon at the first stage was 11.5 kg., The force required to rupture the suture reinforced with the plantaris tendon at the second stage measured 33.4 kg. The force required to rupture the suture reinforced with a portion of the peroneus longus tendon at the third stage was 37.3 kg. Conclusion The new techniques offered to reinforce the Achilles tendon with the plantaris tendon and a portion of the peroneus longus tendon at the distal base facilitated increase in the strength of the injury site by 195.6 % and 214.4 %, respectively.
Repair of open humerus fracture and extensive bone defect using bone grafting (case report)
Authors:   Samarkand branch of the Republican Specialized Scientific and Practical Medical Center for Traumatology and Orthopedics, Samarkand, Uzbekistan, Davirov Sh.M. , Urinboev P.U. ,   Samarkand branch of the Republican Specialized Scientific and Practical Medical Center for Traumatology and Orthopedics, Samarkand, Uzbekistan
Published: March 2022

Introduction Treatment of a patient with an open comminuted humerus fracture and an extensive bone defect is challenging and associated with high risk of a poor outcome, infection resulting from skin and soft tissue injury and considerable bone transport. The objective of the study is to demonstrate the experience with an open comminuted humerus fracture and an extensive bone defect treated with staged use of transosseous fixation with rod-andwire device, autologous fibula graft and internal wiring. Material and methods We report a case of an open humerus fracture and an extensive bone defect treated with a bone replacement technique and followed up to 4 years. Results and discussion The limb was temporarily fixed with external fixation device extrafocally using wires and rods. A 24 cm autograft was harvested from the fibula. Osteosynthesis of the humerus and autografting were produced with the graft fixed using smooth wires and external fixation was provided using wires and rods. With consolidation of the humerus achieved, the external fixation device was dismantled and transosseous wires removed. Anatomical length of the segment was restored. Conclusion Combined techniques and technical means of external fixation, autologous graft, internal fixation with smooth wires facilitated complete restoration of the injured limb avoiding complications with a good clinical outcome.
Editorial
Authors: Villa Villa Sandra
Published: March 2022

Siempre que me es otorgado el privilegio de escribir estas líneas, vienen a mi memoria los compañeros docentes que nos han acompañado en cada una de las ediciones de nuestra revista Advocatus, algunos de los cuales ya se marcharon físicamente, sin embargo, permanecen inamovibles en nuestros más gratos recuerdos.

Hemos llegado a nuestra edición No 37, y con enorme agrado manifiesto, que, si bien cada una de las anteriores publicaciones estuvieron cargadas de artículos absolutamente interesantes para la comunidad académica, en esta ocasión, la exquisites aflora en cada capítulo, cargados de temáticas que hoy día están a la vanguardia de la investigación científica y tecnológica.
ESTADO SOCIAL DE DERECHO - PRESUPUESTO PÚBLICO CON SENTIDO DE HUMANIDAD - ECO SUSTENTABLE
Authors: Salazar Jose Hoover
Published: March 2022

En el presente artículo se adelanta un acercamiento al presupuesto Público con sentido de humanidad, eco sustentable, que reconozca como sujeto a las especies vivas y a la naturaleza. Las reflexiones parten del Estado Social de Derecho, como concepto, como cultura, bajo una racionalidad humanista de la filosofía de las ciencias económicas y presupuestales. Se cuestiona la mundialización, la apertura económica, el Neoliberalismo, no solo como responsable de la crisis mundial de los año 1930 y las crisis de las últimas tres décadas, sino porque no pudo dar respuesta a la crisis desatada por la pandemia del COVID 19, donde finalmente fue el Estado interventor, con un presupuesto de inversión y gasto público social con el que se está haciendo frente a temas de salud, desempleo, pobreza, reactivación económica, subsidio a las nóminas, subvenciones y auxilios presupuestales, entre otros. Igualmente, se colige la necesidad de construir consensos, en la única forma de gobierno de la modernidad, válida para hacer efectivos derechos económicos, sociales, ambientales y culturales, esto es, la democracia, entendida como cultura, como participación de la sociedad. Se concluye que, en el Estado Social de Derecho los presupuestos deben ser autónomos, previsivos, suficientes, que respeten los derechos de las especies vivas y la naturaleza, que sea un instrumento para decisiones con sentido de humanidad, frente a la pobreza, la marginalidad y la desigualdad
The Analysis of a Learning Management System from a Design and Development Perspective
Authors:   the Department of computer science, Information Technology College, Zarqa University-Jordan, Jordan, Alia Abdallah Ahmed Hassan
Published: March 2022

The use of information technology as a means of educating students has become a popular trend. For this purpose, a special type of content management system was used, called learning management systems (LMS) and course management systems (CMS). Often all of these platforms offer similar features and users cannot choose the one that best suits them. This article proposes an analysis of the usability and functionality of software in LMS frameworks. Based on the integration of parallel work on the same database, you can automatically synchronize and manage accounts, users, sessions, and distribute (session and user) easily. There is no need to manually enter data in two different systems. This increases the value of the learning management system used by improving time and accuracy. By first, reducing the time creating learning materials within the LMS. Second, the accuracy in creating the learning materials within the LMS. Third: Accuracy in distributing students and teachers to the course. Fourth, configure the class room inside the LMS that matches the CMS one hundred percent. It includes subjects, departments, faculties and users (students and teachers). The contribution of this paper provides a rich recent direction of software methodologies for web-based learning management systems from a design and development perspective.
Analysis of Mustahik Empowerment Program in Indonesia: The Case of Non-State Zakat Organization
Authors: Mawardi Mawardi , Trianto Budi , Masrizal Masrizal
Published: March 2022

The mustahik (the poor and the needy) empowerment program is one of the priority activities carried out by the zakat institution. This study aims to determine whether organizational support and entrepreneurial characteristics possessed by mustahik affect the success of the mustahik empowerment program. This study also aims to determine whether the mustahik empowerment program can alleviate poverty. This research was conducted utilizing Partial Least Square-Structural Equation Modelling (PLS-SEM) method. The population in this study was the mustahiks who received empowerment programs from non-governmental zakat organizations in Pekanbaru City, with a total sample of 60 mustahiks. The results of this study found that there was a positive and significant relationship between organizational support and the mustahik empowerment program. This study also uncovered a significant positive relationship between entrepreneurial characteristics and the mustahik empowerment program. It was also unveiled that the mustahik empowerment program had a positive and significant relationship with the success of poverty alleviation. These results imply that organizational support and entrepreneurial characteristics are important variables in the mustahik empowerment program. Therefore, zakat institutions must pay more attention to these variables to get maximum results in poverty alleviation.
Políticas de cotas na UEPG: análise do abandono e do rendimento acadêmico
Authors: Pelinski Raiher Augusta
Published: March 2022

Este artigo teve como objetivo avaliar o abandono e a eficiência (em termos de nota média) dos alunos cotistas versus os não cotistas da Universidade Estadual de Ponta Grossa (UEPG), subdividindo a análise entre licenciatura e bacharelado. Para isso, os alunos foram acompanhados durante pelo menos oito anos e, na sequência, aplicou-se o método Propensity Score Matching. Como corolário, não se encontrou diferença significativa entre o rendimento médio dos graduados cotistas versus os de entrada universal. No caso do abandono, constatou-se menor desistência dos alunos cotistas, especialmente quando se analisou os cursos de bacharelado.
Evaluation of bladder washings cytology in diagnosis of neoplasms of urinary bladder
Authors: Dalal Niti , Chhabra Sonia , Tehri Gourav , Kamal Hemant , Gupta Monika , Sen Rajeev
Published: March 2022

Urinary cytology functions as the primary screening and surveillance modality for the detection of urothelial neoplasia.

To determine the significance of urinary bladder wash cytology in predicting various grades of urothelial carcinoma of urinary bladder along with their histological confirmation.

The prospective study was conducted in Department of Pathology, PGIMS, Rohtak. A total of thirty-one urinary bladder washing samples (processed by Conventional method, Cytospin and Liquid based cytology) were taken prior to biopsy from clinically suspected patients of urinary bladder neoplasm. The cytological examination of bladder washings was reported according to The Paris System for Reporting Urinary Cytology and Bladder biopsies were reported according to WHO/ISUP grading of Urothelial Tumors 2004.

All the data were statistically analysed using SPSS version 20.0 software.

There was no significant difference in diagnostic accuracy among three techniques of processing bladder washings. Correlations of cytological diagnosis on bladder wash specimens with histopathological diagnosis were statistically significant and shared good agreement.

A negative bladder wash cytology coupled with a negative cystoscopy is quite specific. A diagnosis of positive or suspicious bladder wash should be thoroughly investigated and followed closely. The Paris System is easy, reproducible, consistent ad has good histopathological correlation.
Tumour budding in colorectal carcinoma: Association with other histopathological prognostic parameters
Authors: Mishra Pragnya P , Madan K , Biswas Siddhartha , Rao Anuradha Calicut Kini , Shetty Rohan , Panda Premanand
Published: March 2022

Colorectal carcinoma (CRC) is the third leading cancer in India. Pathologists play a crucial role in assessing stage, analyzing surgical margins and documenting the histopathologic prognostic parameters. Tumour budding is one such prognostic parameter, defined as single cells or small groups of tumour cells (up to 4 cell clusters) at the invasive front of the tumour.

The aim of this study is to examine the association of tumour budding with other histopathological prognostic parameters in patients with colorectal carcinoma.

TheHematoxylin & Eosin (H &E) stained slides of 52 histopathologically diagnosed CRC resection specimens were reviewed and tumour budding (BD) was assessed into four grades under 200x power. Other histopathological prognostic parameters like tumour size, site, grade, laterality, lymphovascular invasion, perineural invasion, T and N stage were analyzed using descriptive statistics and Chi-square test with Software SPSS version 23.

A higher BD score is seen to be more often associated with grade 3 tumour morphology, presence of perineural invasion, tumour size of 5cm or more and tumours located in the sigmoid colon or rectum. No association of tumour budding is seen with TIL’s or tumour of size < 5cm.

Tumour budding is a practical and significant histological index for identification of high malignant potential and poor outcome in CRC patients with rectal or sigmoid colon location, size more than 5cm, perineural invasion and higher histological grade. Tumour budding may help identify patients who need a more intensive postoperative follow up and the possibility of adjuvant therapy.
HydroBID Flood como herramienta de planificación del saneamiento urbano: El modelaje numérico de pluma de contaminantes como apoyo al diseño de plantas de tratamiento en Paraguay
Authors: Nalesso Mauro , Bogado Eduardo , Manjarrés José Francisco , Monte Domecq Federico
Published: March 2022

Las infraestructuras para tratamiento de las aguas residuales son uno de los componentes más costosos del servicio integral de saneamiento. Por ello es importante que durante el proceso de planificación del saneamiento se consideren, en adición a los aspectos técnicos y económicos, los factores sociales y ambientales. El modelo HydroBID Flood fue implementado en dos plantas de tratamiento en diseño en Paraguay para evaluar el efecto de las emisiones en la calidad de las aguas de los ríos Paraguay y Paraná y verificar que cumplen con las normas ambientales.
Guía práctica de financiación basada en resultados en el sector de agua y saneamiento
Authors: Agusti Strid Alma , Mendoza Mora Cristina , Holler Siegrid , Chaskel Sebastián
Published: March 2022

Este documento tiene el objetivo de servir como una guía práctica acerca de La Financiación Basada en Resultados (FBR) en el sector de agua y saneamento. La FBR, o a veces denominado Pay-for-Success (PfS), es una modalidad de financiación que cada vez está cobrando mayor relevancia, y apunta a incentivar el mejor desempeño de los agentes del sector, de tal manera que maximice el impacto de los recursos disponibles. Cabe resaltar que la FBR es una innovación financiera en sí y, al mismo tiempo, promueve soluciones y prácticas innovadores, al otorgar a los agentes incentivados más discreción en cuanto a su estrategia, o en la búsqueda de soluciones o prácticas innovadoras para el logro de mejores resultados.
Nonlinear Finite Element Structural Analysis of Reinforced Concrete Beams with out of Plane Parts
Authors: Mohsin Murtada S. , Alwash Nameer A. , Kadhum Mohammed M.
Published: March 2022

The purpose of this study was to investigate and compare the structural behavior of the reinforced concrete beams contain out of plane parts with the straight beam by finite element analysis (FEA) using ABAQUS software package. The studied models were evaluated by comparing their results with previous experimental results of the research done by the same authors. The study focused on the effects of the number of the out of plane parts on the beams' mid span deflection, the cracking and ultimate loads, and failure mode. The obtained results showed that load bearing capacity of the beams with one, two, and three out of plane parts was lower than the capacity of the straight beam by about 35%, 33%, and 68%. In addition, the results of the beams with an even number of out of plane parts were generally better than the results of those with odd number, and the increasing number of out of plane parts changed the failure mode from flexure to combined flexure plus torsion. Finally, the FEM analysis was comparable with those obtained from the experimental procedures with an average difference ratio not exceeding 5% in the ultimate load and 7% in the deflection.
Physical (PHY) Layer Analysis of Data Transmission in MIMO Wireless Networks in Line- of-Sight (LoS) Environments
Authors: Premkumar M. , Arun M. , Priya S. Sathiya , Prathipa R. , Gurupandi D.
Published: March 2022

This research paper presents the Physical (PHY) layer analysis of multiple input multiple output (MIMO) systems in line-of-sight environments between a user equipment (UE) and a base station when an information data is transmitted. The data transmission in wireless networks often takes place in non-line-of-sight in urban environments and Line-of-Sight (LoS) in rural environments depending on the bandwidth, power constraints. Using MIMO technology, the data transmission takes place with increased number of transmit and receive antennas which results in reduced signal to noise ratio (SNR) requirement. In this research work, simulation for PHY layer metric of probability of error, mean square error (MSE) for data transmission in MIMO wireless networks is obtained Matrix Laboratory (MATLAB) for LoS environment which follows Rician distribution. Probability of error reduces to a significant extent when the Rician factor increases as the line-of-sight component prevails which also takes lesser power in the lower SNR limits. Further, in MIMO systems also the probability of error and MSE reduces in concatenation with single antenna terminals thereby exploring power control a significant possibility for implementation in massive MIMO and millimeter wave communication systems for 5G and 6G systems.
Information Services in Evidence Based Medical Education: A Review of Implementation Trends
Authors: Khani Sedigheh , Panahi Sirous , Pirsalehi Ali , Pourabbasi Ata
Published: March 2022

Objective – Evidence based medical education requires supportive information services to facilitate access to the needed educational evidence. Information services designed specifically for evidence based medical education are limited or locally developed for educational units. For librarians to have an opportunity to cooperate efficiently with medical educators in evidence based medical education, they require an empirical prototype for transmission of clinical evidence at the right place and the right time. Therefore, there is a need to recognize types of information services which support evidence based medical education. The purpose of this review is to identify implementation trends of evidence based educational information services.
Methods – We found related studies by implementing search strategies in PubMed, EMBASE, Web of Science, Scopus, LISTA, and Google Scholar with keywords like: evidence based medical education, information services, and library services. We used reference-checking and citation-checking of related articles for completing the process of locating relevant articles. After employing inclusion and exclusion criteria, we selected 11 articles for inclusion in the review and analyzed them using a narrative review technique.
Results – After analyzing the results of the included studies, we identified two elements categorized as program development and five elements categorized as implementation trend. Prerequisites of program and the process of designing were essential parts of program development of information services. Schedule and type of access, how to receive educational-clinical questions, information services types, responding time, and providing evidence based outputs were the elements of the implementation process of educational supported information services. 
Conclusion – Designing an evidence based educational information service strongly depends on the information needs of learners at each educational level. Schedule and type of access to information service, time of responding to the received query, and preparation of evidence based output are essential factors in designing practical educational-developed information services.
Constitutional-legal and socio-economic prerequisites and goals for the creation of federal territories in the Russian Federation and abroad
Authors:   Saratov State University, Starikov Sergey S.
Published: March 2022

Introduction. The establishment of the possibility of creating federal territories in the Constitution of the Russian Federation and the subsequent adoption of the Federal Law “On the Federal Territory “Sirius” No. 437-FZ of December 22, 2020 make us take a closer look at foreign experience in determining the constitutional legal status, mechanisms of creation and features of functioning of federal territories. Carrying out a comparative analysis will make it possible to predict the prospects for further development of legislation on the creation and identification of the main goals of functioning of federal territories. Theoretical analysis. The review of the types of federal territories and federal districts in the constitutional and legal practice of foreign states allows us to conclude that their creation requires a system of constitutional-legal and socioeconomic prerequisites. The main prerequisites include establishment of the possibility, goals and mechanisms of creation of a federal territory in the Constitution of the state, the definition of the spatial and geographical characteristics of the federal territory, as well as the peculiarities of the legal regime of public authority exercised in this territory in the legislation of the state. Empirical analysis. Russia has quite a lot of experience in creating a legal framework for socio-economic, environmental, scientific and technological development in individual territories, which was taken into account when creating the Federal Law on Sirius. Results. At present, the main constitutional-legal and socio-economic prerequisites for the creation of new federal territories of Russia have been formed. These prerequisites are of an objective nature and are generally comparable with the experience of foreign countries with the state territorial structure that includes federal territories. The goals of creating federal territories in Russia and foreign countries have their own specifics. Abroad, such goals, as a rule, are the special status of the capital, construction of defense structures, environmental protection, and preservation of the specifics of the territories where indigenous peoples live. In Russia, the federal territory “Sirius” was created in order to ensure the socio-economic and innovative development of the territory, to increase its investment attractiveness, to preserve the Olympic sports, cultural and natural heritage, to create favorable conditions for identification, self-realization and development of talents, implementation of priorities in scientific and technological development of the Russian Federation. In foreign practice, as a rule, the mechanisms for creating federal territories are not used for these purposes, but other socio-economic and organizational-legal instruments are applied.
Modeling the dynamics of regional competitiveness risks
Authors:   Saratov State University, Chernyshova Galina Yu. , Veshneva Irina V. ,   Saratov State University, Rokakh Gleb E. ,   Saratov State University
Published: March 2022

Introduction. To determine the strategic directions of regional development to increase competitiveness, it is necessary to rely on a systematic analysis of factors and risks, to use modern mathematical modeling tools. To construct dynamic models for assessing the risks of competitiveness, an approach based on the systems of Kolmogorov – Chapman differential equations for Markov processes is applied. Theoretical analysis. The article examines the method of applying the logical-probabilistic approach to assessing the risks of regional competitiveness. Empirical analysis. For a comparative assessment of the risks of competitiveness at the stage of preliminary data processing, cluster analysis was applied using a modified k-means method. Based on the hierarchical system of regional competitiveness risks, the system of Kolmogorov – Chapman equations is formed. Dynamic assessment of competitiveness risks was carried out for three basic scenarios. Results. For a selected cluster of 33 Russian regions corresponding to a high level of socio-economic development, predictive estimates of the probabilities of critical events associated with risks of competitiveness were obtained using the example of a separate section. For optimistic, pessimistic and realistic scenarios, numerical assessments of competitiveness risks are obtained for various combinations of critical events. This made it possible to rank the regions by the probability of a decrease in the competitiveness of the regions in the medium term.
Legislation as a factor in the development of public-private partnership in the sphere of information technologies
Authors:   Ural State University of Economics, Savchenko Yana. V. , Nuraev Timur A. ,   Ural State University of Economics
Published: March 2022

Introduction. Public-private partnership (PPP) in world practice has established itself as an effective tool for interaction between business and government in the implementation of socially significant projects. The state got the opportunity to attract a private investor to solve strategic problems of social development. Information technology (IT) is no exception. In the context of globalization and digitalization of the economy, development of information technology sphere is becoming highly relevant, since it determines the level of information security and development of the country as a whole. Theoretical analysis. The main research method was the analysis of the basic laws governing public-private partnerships in the IT sphere both in Russia and abroad, which made it possible to identify the differences in the PPP legislation of different countries. Empirical analysis. The analysis of the legislation of different countries in the field of public-private partners in relation to the IT industry enabled the authors to divide countries into four groups, depending on the characteristics and level of its development. The first group of countries is characterized by the absence of a law on PPP at the state level, application of international legal norms and availability of methodological recommendations in the field of PPP. In the second group, countries have a fundamental law on PPP without specifying the spheres of its application, or a list of spheres has been formed and it includes the IT industry. In the third group, there is a general law on PPP with a list of specific areas that does not include the sphere of information technology. The fourth group of countries has no legislation on PPP. Results. The authors identified the problems of legislation in the field of public-private partnership in relation to IT projects. In particular, it was determined that Russian laws in the field of PPP have relatively more specificity in relation to IT projects than foreign ones. However, this is far from always being good and creates artificial restrictions for the development of this mechanism for attracting a private partner to finance IT projects that are significant for society. The highlighted shortcomings of the Russian legislation will help to improve efficiency and controllability of PPP projects in the IT sphere, when eliminated.
Características de la Cognición Social en infractores de la ley: Revisión teórica
Authors: Quintero López Catalina , Daniel Gil Vera Víctor , De Ángel Martínez Luis Eduardo , Bustamante Hernández Alejandra Vanesa
Published: March 2022

Los jóvenes infractores de la ley con estructura antisocial tienen alteraciones en la cognición social, lo que se ve reflejado en la dificultad para interactuar con los demás de manera adecuada y ponerse en el lugar del otro como símbolo empático. Se presentan los hallazgos de una revisión sistemática de literatura para dar respuesta a las siguientes preguntas de investigación: ¿Cuáles son las características de la empatía y simpatía en infractores de la ley? ¿Cuáles son las características del razonamiento moral en infractores de la ley?. Se revisaron artículos, libros y publicaciones especializadas en bases de datos científicas. Se concluye que el infractor de la ley con estructura antisocial tiene un funcionamiento neurobiológico diferente al delicuente común, específicamente en las áreas cerebrales asociadas a las respuestas de empatía, simpatía y razonamiento moral; en estos se activan respuestas biológicas placenteras frente a situaciones que generan en la mayoría de la población sentimientos de compasión y dolor. Los hallazgos reportan que las personas con estructura antisocial sienten satisfacción ante el dolor del prójimo, demostrando afectaciones en la cognición social, siendo éste un tema de interés y actualidad para las neurociencias y la neuropsicología social.