bluuebunny/crossref_metadata_2025 huggingface dataset:
Unique spatially and temporary-regulated/sex-specific expression of a long ncRNA, Nb-1, suggesting its pleiotropic functions associated with honey bee lifecycle
Authors: Tadano Hiroto , Kohno Hiroki , Takeuchi Hideaki , Kubo Takeo
Published: April 2024

Honey bees are social insects, and each colony member has unique morphological and physiological traits associated with their social tasks. Previously, we identified a long non-coding RNA from honey bees, termed Nb-1, whose expression in the brain decreases associated with the age-polyethism of workers and is detected in some neurosecretory cells and octopaminergic neurons, suggesting its role in the regulation of worker labor transition. Herein, we investigated its spatially and temporary-regulated/sex-specific expression. Nb-1 was expressed as an abundant maternal RNA during oogenesis and embryogenesis in both sexes. In addition, Nb-1 was expressed preferentially in the proliferating neuroblasts of the mushroom bodies (a higher-order center of the insect brain) in the pupal brains, suggesting its role in embryogenesis and mushroom body development. On the contrary, Nb-1 was expressed in a drone-specific manner in the pupal and adult retina, suggesting its role in the drone visual development and/or sense. Subcellular localization of Nb-1 in the brain during development differed depending on the cell type. Considering that Nb-1 is conserved only in Apidae, our findings suggest that Nb-1 potentially has pleiotropic functions in the expression of multiple developmental, behavioral, and physiological traits, which are closely associated with the honey bee lifecycle.
Soil respiration and its response to climate change and anthropogenic factors in a karst plateau wetland, southwest China
Authors: Jia Hongyu , Fei Xuehai , Zhu Jingyu , Chen Weiduo , Chen Rui , Liao Zhangze , Zhou Binghuang , Huang Yingqian , Du Haiqiang , Xu Peng , Zhang Xu , Li Wangjun
Published: April 2024

It is important to investigate the responses of greenhouse gases to climate change (temperature, precipitation) and anthropogenic factors in plateau wetland. Based on the DNDC model, we used meteorological, soil, and land cover data to simulate the soil CO2 emission pattern and its responses to climate change and anthropogenic factors in Guizhou, China. The results showed that the mean soil CO2 emission flux in the Caohai Karst Plateau Wetland was 5.89 ± 0.17 t·C·ha−1·yr−1 from 2000 to 2019, and the annual variation showed an increasing trend with the rate of 23.02 kg·C·ha−1·yr−1. The soil total annual mean CO2 emissions were 70.62 ± 2.04 Gg·C·yr−1 (annual growth rate was 0.28 Gg·C·yr−1). Caohai wetland has great spatial heterogeneity. The emissions around Caohai Lake were high (the areas with high, middle, and low values accounted for 3.07%, 70.96%, and 25.97%, respectively), and the emission pattern was characterized by a decrease in radiation from Caohai Lake to the periphery. In addition, the cropland and forest areas exhibited high intensities (7.21 ± 0.15 t·C·ha−1·yr−1 and 6.73 ± 0.58 t·C·ha−1·yr−1, respectively) and high total emissions (54.97 ± 1.16 Gg·C·yr−1 and 10.24 ± 0.88 Gg·C·yr−1, respectively). Croplands and forests were the major land cover types controlling soil CO2 emissions in the Caohai wetland, while anthropogenic factors (cultivation) significantly increased soil CO2 emissions. Results showed that the soil CO2 emissions were positively correlated with temperature and precipitation; and the temperature change had a greater impact on soil respiration than the change in precipitation. Our results indicated that future climate change (increased temperature and precipitation) may promote an increase in soil CO2 emissions in karst plateau wetlands, and reasonable control measures (e.g. returning cropland to lakes and reducing anthropogenic factors) are the keys to controlling CO2 emissions.
Intake of the different types of dairy products, genetic predisposition, and the risks of nonalcoholic fatty liver disease and cirrhosis: a prospective cohort study
Authors: Wu Hanzhang , Li Shiwen , Chen Liangkai , Xia Yang , Tan Xiao
Published: April 2024

The association of different types of dairy product consumption with nonalcoholic fatty liver disease remains controversial.
The interplay between crystallinity and the levels of Zn and carbonate in synthetic microcalcifications directs thyroid cell malignancy
Authors: Gotnayer Lilian Lotem , Nahmias Yarden , Yazbek Grobman Gabriel , Friedlander Lonia , Aranovich Dina , Yoel Uri , Vidavsky Netta
Published: April 2024

Microcalcification analogs with various Zn levels and crystallite sizes were synthesized to investigate their impact on thyroid cancer cell behavior.
A liquid metal/polypyrrole electrospun TPU composite conductive network for highly sensitive strain sensing in human motion monitoring
Authors: Du Juan , Han Qinghui , Chen Aibing
Published: April 2024

Developing soft wearable sensors with high sensitivity, low cost, and a wide monitoring range is crucial for monitoring human health.
Fe-based cyclically catalyzing double free radical nanogenerator for tumor-targeted chemodynamic therapy
Authors: Wang Yang , Zhu Chunquan , Fan Xiaohui , Yang Yuanyuan , Chen Zhaoxia , Yu Li , Zhang Yuhong
Published: April 2024

A tumor-targeted diradical nanogenerator based on mesoporous silicon nanoparticles was reported to cyclically catalyze the intracellular Fenton reaction for enhanced chemodynamic therapy.
Conductive MXene nanocomposite organohydrogels for ultra-stretchable, low-temperature resistant and stable strain sensors
Authors: Liu Yafei , Gui Yujie , Lv Ying , Feng Huixia , Zhao Xia , Qiu Jianhui , Ma Xuemei , Yang Yuchen
Published: April 2024

Hydrogels have unique flexibility and a highly efficient, low-cost manufacturing process, thus they are expected to be used in electronic skin, wearable sensors, soft robotics, and human–computer interaction.
Quantifying platinum binding on protein-functionalized magnetic microparticles using single particle-ICP-TOF-MS
Authors: Bradley Veronica C. , Manard Benjamin T. , Hendriks Lyndsey , Dunlap Daniel R. , Bible Amber N. , Sedova Ada , Saint-Vincent Patricia , Sanders Brian C. , Andrews Hunter B.
Published: April 2024

This work describes an analytical procedure, single particle-inductively coupled plasma-time-of-flight-mass spectrometry (SP-ICP-TOF-MS), that was developed to determine the platinum binding efficiency of protein-coated magnetic microparticles.
Alkali metal modified Pt/EG-TiO2 catalysts for CO oxidation with efficient resistance to SO2 and H2O
Authors: Zhu Hongtai , Qiu Wenge , Wu Rui , Li Kai , He Hong
Published: April 2024

Doping 0.15 wt% Na in Pt/EG-TiO2 catalysts could significantly improve the CO oxidation activity and resistance to SO2 and H2O, which provides a new route for the development and industrial applications of the Pt-based catalysts with good SO2 and H2O resistance.
Cell membrane coated nanoparticles as a biomimetic drug delivery platform for enhancing cancer immunotherapy
Authors: Zhong Zichen , Deng Wen , Wu Jian , Shang Haojie , Tong Yonghua , He Yu , Huang Qiu , Ba Xiaozhuo , Chen Zhiqiang , Tang Kun
Published: April 2024

Graphical abstract of CMNPs delivering different therapeutic agents for enhancing cancer immunotherapy.
Low-temperature synthesis of porous organic polymers with donor–acceptor structure and β-ketoenamine for photocatalytic oxidative coupling of amines
Authors: Sang Rusong , Hu Yezi , Shen Zewen , Zhao Guixia , Yue Junrong , Huang Xiubing
Published: April 2024

In light of the widespread use of fossil fuels and the resulting environmental pollution, it is crucial to develop efficient photocatalysts for renewable energy applications that utilize visible light.
Identifying biochemical constituents involved in the mycosynthesis of zinc oxide nanoparticles
Authors: Brady Nathan G. , O'Leary Shamus L. , Kuo Winson , Blackwell Brett R. , Mach Philip M. , Watt John , Bachand George D.
Published: April 2024

We characterized the proteomes and metabolomes of fungal exudates that enable the mycosynthesis of zinc oxide nanoparticles.
Recent progress in the study of integrated solar cell-energy storage systems
Authors: Lu Yanqinpeng , Chen Mengxiang , Zhu Guoyin , Zhang Yizhou
Published: April 2024

The intermittent nature of solar energy calls for integrated solar cell-energy storage systems that combine solar cells with various energy storage devices. This review summarizes recent advancements in these integrated systems, including design, performance evaluation and applications.
Cu(OTf)2/HFIP catalyzed regioselective cycloisomerization of indole-C3-functionalized alkynols to carbazoles
Authors: Yaragorla Srinivasarao , Khan Tabassum , Chakroborty Sayonika
Published: April 2024

We report here a simple and atom economic cycloisomerization reaction of indole-tethered alkynols for constructing diverse carbazoles via 1,2-alkly migration using Cu(OTf)2/HFIP as the excellent promoter system.
A direct one-step synthesis of a smart graphene/silica nanocomposite and its application for improving the acid resistance and corrosion resistance properties of waterborne epoxy coatings
Authors: Jia Yanling , Zhang Ke
Published: April 2024

A smart BTA@SN-rGO nanocomposite was obtained via a one-step synthetic method and can provide remarkable long-term corrosion protection on metal.
Na3V2(PO4)3-decorated Na3V2(PO4)2F3 as a high-rate and cycle-stable cathode material for sodium ion batteries
Authors: Yang Yi , Xu Guo-Rong , Tang An-Ping , Zheng Jun-chao , Tang Lin-Bo , Huang Ying-De , Chen He-Zhang
Published: April 2024

Na3V2(PO4)2.75F0.75/C (NVPF·3NVP/C) composite cathode material was synthesized by sol–gel method. Compared to other composite materials, NVPF·3NVP/C electrode materials exhibit excellent rate performance.
Nanoelectrochemistry reveals how presynaptic neurons regulate vesicle release to sustain synaptic plasticity under repetitive stimuli
Authors: Zhang Fu-Li , Yang Xiao-Ke , Qi Yu-Ting , Tian Si-Yu , Huang Wei-Hua
Published: April 2024

Nanoelectrochemistry reveals changes in vesicle recycling and exocytosis dynamics, accompanied by dense core vesicle release in the dopaminergic synaptic cleft under repetitive stimuli.
An innovative nucleation method for high and rapid hydrogen storage based on clathrate hydrates
Authors: Chen Siyuan , Wang Yanhong , Fan Shuanshi , Lang Xuemei , Li Gang
Published: April 2024

A novel and simple method called quasi-simultaneous formation of hydrates was proposed for ultra-rapid and high hydrogen uptake.
Opportunities to Respond During Dyadic Caregiver–Child and Naturalistic Family Interactions Among Children With Down Syndrome: A Preliminary Investigation
Authors: Elmquist Marianne , Ford Andrea L. B. , Lorang Emily , Sterling Audra
Published: April 2024

Purpose:

Dyadic caregiver–child interactions are commonly used to examine children's language learning environments. However, children frequently interact with multiple caregivers and/or siblings if they come from homes with multiple caregivers and siblings. Thus, we examined if and how caregiver opportunities to respond (OTRs) varied when sampled across three interaction configurations.

Method:

Twelve children with Down syndrome (
M
age
= 40.82 months) and their biological parents participated in the current study. We collected separate mother–child and father–child dyadic interactions and one family choice interaction (i.e., both caregivers present and occasionally siblings) in families' homes. We analyzed if differences in the caregiver's OTR frequency and type—explicit and implicit—existed among dyadic and family choice configurations.

Results:

We found that, during family choice interactions, children were exposed to fewer OTRs when combining the total number of father and mother OTRs compared to dyadic caregiver–child interactions. This effect was large for explicit OTRs (mother-dyadic vs. combined family choice:
g
= −1.99, confidence interval [CI] [−3.00, −1.00]; father-dyadic vs. combined family choice:
g
= −0.84, CI [−1.84, −0.11]). For implicit OTRs, effects were small for mother-dyadic versus combined family choice (
g
= −0.34, CI [−1.17, 0.48]) and negligible when comparing father-dyadic with combined family choice (
g
= −0.08, CI [−0.90, 0.73]).

Conclusion:

Our preliminary findings highlight the need for a more nuanced understanding of children's language learning environments to better understand how caregivers support their children's language development.

Supplemental Material:

https://doi.org/10.23641/asha.25579905
The role of heating in the formation and the dynamics of YSO jets
Authors: Meskini C. , Sauty C. , Marcowith A. , Vlahakis N. , Brunn V.
Published: April 2024

Context. Theoretical arguments as well as observations of young stellar objects (YSOs) support the presence of a diversified circumstellar environment. A stellar jet is thought to account for most of the stellar spin down and disk wind outflow for the observed high mass-loss rate, thus playing a major role in the launching of powerful jets. RY Tau, for instance, is an extensively studied intermediate mass pre-main sequence star. Observational data reveal a small-scale jet called micro-jet. Nevertheless, it is not clear how the micro-jet shapes the jet observed at a large scale.

Aims. The goal is to investigate the spatial stability and structure of the central jet at a large scale by mixing the stellar and disk components.

Methods. Two existing analytical self-similar models for the disk and the stellar winds to build the initial setups. Instead of using a polytropic equation of state, we mapped the heating and cooling sources from the analytical solutions. The heating exchange rate was controlled by two parameters, its spatial extent and its intensity.

Results. The central jet and the surrounding disk are strongly affected by these two parameters. We separate the results into three categories, which show different emissivity, temperature, and velocity maps. We reached this categorization by looking at the opening angle of the stellar solution. For cylindrically, well-collimated jets, we have opening angles as low as 10° between 8 − 10 au, and for the wider jets, we can reach 30° with a morphology closer to radial solar winds.

Conclusions. Our parametric study shows that the less heated the outflow is, the more collimated it appears. We also show that recollimation shocks appear consistently with UV observations in terms of temperature but not density.
Preparation and characterization of graphene film using biogas derived from oil palm empty fruit bunch (OPEFB) by chemical vapor deposition (CVD) method
Authors: Zainal Wan Nur Aina Wan , Ayob Nur Idayu , Rozhan Alya Naili , Yusof Nurhafizah Abu Talip , Zulkifli Zurita
Published: April 2024

This study aims to fabricate graphene films using biogas derived from oil palm empty fruit bunch (OPEFB) as carbon precursors using chemical vapor deposition (CVD) method under various conditions. The fabricated graphene films were deposited on copper substrates at different temperatures and gas compositions. Scanning Electron Microscopy (SEM), Raman Spectroscopy, and the I-V test were used to analyze and characterize the properties of the fabricated film. From the characterization results, SEM images of films grown at 800°C (without additional H2gas), and 900°C (without additional H2gas) show a not so well-defined hexagonal domain shape with non-uniform morphology with variations in domain shape and orientation, while Raman spectra show it has only the D band and G band which are attributed to graphene oxide. On the other hand, at 900°C (with additional H2gas), the SEM image shows more defined hexagonal domain shape and variations in domain shape and orientation, as well as the D, G and 2D band on the Raman spectra, which are like graphene with defects structure. Hence, it is concluded that graphene film was successfully produced at 900°C with additional H2gas.
Enhancing the environmental sustainability of water treatment sludge (WTS) disposal through blended binder solidification/stabilisation
Authors: Muhammad Fauzi Nurshamimie , Arshad Mohd Fadzil , Putra Jaya Ramadhansyah , Mukri Mazidah , Khiyon Nor Hanim
Published: April 2024

Managing water treatment sludge (WTS) is challenging due to its continuous production and environmental impact. Traditional disposal in landfills is standard but risky for groundwater contamination. Researchers are exploring a more environmentally friendly method using a blend of binders, partially replacing Ordinary Portland Cement (OPC) with waste materials like Waste Paper Sludge Ash (WPSA), Palm Oil Fuel Ash (POFA) and Fly Ash (FA). These materials not only help reduce environmental waste but also decrease cement usage. The study assesses the Atterberg Limits of the treated sludge to design the appropriate solidification/stabilisation (S/S) method, providing essential data on its physical and mechanical properties Using waste materials as binders effectively stabilises the sludge, reducing reliance on cement, cutting disposal costs, and minimizing environmental pollution. The study identifies WPSA as the most suitable replacement, offering self-cementing properties, and demonstrates that combining WPSA OPC, and WTS creates a stable mix with liquefaction resistance. This approach presents a promising, cost-effective, and environmentally solution for WTS management.
Power loss minimization by optimal allocation and sizing of STATCOM via particle swarm optimization
Authors: Wan Abdul Razak Wan Muhamad Akmal , Rosmin Norzanah , Musta’amal Aede Hatib , Hussin Siti Maherah , Mat Said Dalila , Aripriharta
Published: April 2024

The provision of electricity is problematic in remote and rural areas. The distribution system is insufficiently efficient to provide rural areas with electricity. Long distance between the power supply and rural areas is the reason why there is insufficient electricity. Static synchronous compensator (STATCOM) technology is one of the solutions that have more positive effects, such as reducing power losses, and can therefore increase the system’s efficacy. However, the non-optimal allocation and magnitude of STATCOM may increase losses and have a negative impact on power, resulting in a decrease in system efficiency. This paper introduces the Particle Swarm Optimization (PSO) algorithm as the proposed algorithm to optimize the location and capacity of STATCOM in order to reduce power losses in the distribution system. The proposed technique is implemented on a 15-bus IEEE system and simulated using the MATLAB program. The simulation results demonstrate that the optimal location and quantity of the STATCOM proposed by PSO effectively reduces power loss by 6.058% compared to without PSO implementation.
A Bibliometric Analysis on Energy Efficiency and Conservation
Authors: Purwanto Edi , Iskandar Yusuf , Bhaktiar Pinpin
Published: April 2024

Energy efficiency and conservation are pivotal in addressing global energy challenges and promoting sustainability. This paper presents a comprehensive bibliometric analysis spanning 1976 to 2023, aiming to reveal the nuanced dynamics of the field. Utilizing the Scopus database and bibliometric analysis tools like VOSviewer, we explored publication trends, platform rankings, publication types, global distribution, and interconnected research themes. The dominance of top platforms like Energy and Journal of Cleaner Production underscored their significance, with insights into the role of conference proceedings and specialized platforms like Energy Efficiency. Journal articles prevailed, reflecting the academic community’s commitment to peer-reviewed channels, while diverse publication forms and subject areas highlighted a multifaceted approach. The global landscape showcased the United States’ leadership, with impactful contributions from Indonesia, fostering collaboration between developed and developing nations. VOSviewer visualizations revealed interconnected research themes, emphasizing the interdisciplinary nature of climate change and sustainable development. This study offers valuable insights for researchers, policymakers, and practitioners, guiding them to understand historical trends, identify influential platforms, recognize interdisciplinary patterns, and foster global collaborations to shape a more sustainable energy future.
Increasing surface impermeability influences peak discharge with the Snyder method in the Ngadipiro sub-watershed of the Bengawan Solo watershed
Authors: Barid Burhan , Setyaningrum Dias Novita
Published: April 2024

This research was conducted to determine the effect of increasing soil impermeability in the Ngadipiro Sub-watershed on Cp and Ct numbers in 2015 and 2021. The measured unit hydrograph is used as a reference in calculating the Synder synthetic unit hydrograph method. Test the validation of the two methods using the correlation coefficient. The results of this study showed an increase in tightness in the form of an increased runoff coefficient from 0.26 in 2015 to 0.34 in 2021. This increase in tightness is also in line with the increase in peak discharge using the Measured unit hydrograph in 2015 of 73.3757 m3/s and 2021 of 139.1005 m3/s. The results obtained using the Snyder method obtained peak discharges in 2015 and 2021 of 75.10 m3/s and 148.89 m3/s. The results of the correlation test between the two methods obtained very strong correlation results with a 2015 R-value of 0.96 and a 2021 R-value of 0.92. The non-physical parameters of the watershed, namely Ct and Cp, were optimal in the Ngadipiro Sub-watershed in 2015, the Ct value was 2.2 and the Cp value was 0.9, while in 2021 the Ct value obtained was 1.3 and the Cp value was 1.1.
Identifying Significant Policy Barriers for Highway Development in Indonesia
Authors: Novianto Ardi , Riantini Leni Sagita , Latief Yusuf , Pratama Gilang Ardi
Published: April 2024

The development of the Sumatera Toll Road has encountered numerous challenges, including insufficient government intervention, legal issues, ineffective decision-making processes, and other related concerns. The objective of this research is to identify significant policy barriers affecting the performance of the Trans-Sumatra toll road development project. Methods: A questionnaire was administered to a group of seven experts who possessed a minimum of ten years of professional experience and had completed undergraduate education. The responses obtained from the experts were subsequently analyzed using the proposed rough Delphi method. Results: 11 indicators become significant policy barriers during the development process of the Sumatra toll road project. There are delays in project permits and approvals, government intervention, domestic political situations, corruption, SPV breaks policy, contract conflicts, policy and regulation changes, a lack of supporting policies for investors, land status, a lack of standard contract agreements, and a lack of regulatory supervisory and legal systems. Conclusion: The results presented in this paper are important to be considered by the Indonesian government’s government to understand the implementation situation of transportation projects, especially the construction of the Trans-Sumatra toll road.
Analysis and Design of Irregular Structure using Building Information Modelling Integration. Case Study: Laboratory Tower
Authors: Alfredo  , Sjah Jessica , Rarasati Ayomi Dita , Trigunarsyah Bambang
Published: April 2024

In the rapidly evolving Indonesian construction sector, Building Information Modelling (BIM) is gaining substantial momentum, particularly in Indonesia. BIM integration offers comprehensive advantages across the entire building lifecycle. This research centers on applying BIM integration in a 10-story Tower Laboratory at the Department of Civil Engineering, Universitas Indonesia, characterized by structural irregularities. The integration utilizes Autodesk Revit 2023 for BIM modelling and ETABS V21 for structural analysis, employing response spectrum and linear time history methods to assess variations in structural response. The study reveals that response spectrum earthquake loads result in greater responses along the Y-axis, while linear time history earthquake loads lead to increased responses along the X-axis. Spectrum response earthquake loads necessitate an additional 0.64% (21 m³) in cross-sectional area and 1.35% (7805 kgf) more reinforcement compared to linear time history earthquake loads. Additionally, there is a 1.07% cost disparity, amounting to IDR 173,442,791, due to differing analytical methods. This research underscores the potential of BIM in enhancing the construction process, particularly in addressing structural irregularities. The design outcomes and volume calculations from BIM integration can be effectively utilized for life cycle assessments, making it a crucial tool for environmentally conscious and sustainable building practices.
Analysis the Effect of Height on Work Accidents in High Rise Building Projects
Authors: Hartono Widi , Handayani Dewi , Rhamadani Hanis Cahya
Published: April 2024

Indonesia as the population increases, but this is inversely proportional to the availability of land so that the idea of developing high-rise buildings arises. Building projects are high-risk projects, at height there are many hazards such as falling, slipping, falling materials, and electrocution. This study uses a simple linear regression method to see how height affects work accidents and conducts a risk assessment. The results of large-sized companies, height has a significant effect on the risk of falling from height by 30.5%, the risk of eye, skin and respiratory disorders by 14.8% and the risk of being pinched at the work site by 21.4%. In medium-sized companies, height has a significant effect on the risk of falling from height by 15.6% and the risk of eye, skin and respiratory disorders by 11.7%. In small-size companies, height has a significant effect on the risk of falling from height by 12.2% and the risk of being hit by materials from above by 45.5%. The result of the risk assessment for all company qualifications is falling from a height with an average risk index value for large companies of 15.36 (high risk), medium companies 16.52 (high risk) and small companies 8.47 (medium risk).
Effect of Concave Corrugated Tube Shape on The Effectiveness of Double Pipe Heat Exchanger
Authors: Arsana I Made , Wibowo Theodorus Wiyanto , Muhaji  , Sari Handini Novita , Kurniawan Haydar Aly
Published: April 2024

Heat exchangers have an important role in everyday life. A heat exchanger is a device used as a means of energy transformation. The development of heat exchangers undergoes a form transformation that aims to increase efficiency through its work function. Double-pipe heat exchanger with a corrugated tube type is a simple and often applied method used in heat transfer. The use of a concave shape on the corrugated tube aims to increase the convection heat transfer area. The purpose of this research is to determine the effect of using concave shapes on corrugated tubes on the effectiveness of double-pipe heat exchangers. The object of this research is a double pipe heat exchanger with a concave corrugated tube and then varied with triangular, trapezoidal, and square concave shapes. Data collection of experimental results on double pipe heat exchanger using pressure gauge, flowmeter, and thermocontrol as research instruments. The research data were analyzed descriptively calculated theoretically and then converted into graphs and tables. The results achieved to date are the addition of concave shape variations on corrugate tubes can increase the value of thermal conductivity and other characteristics, in the form of a concave triangle with the effectiveness value increased by 11,63%.
Analysis of Utilization of E-Commerce Technology as A Supporting Media in Adding Marketing and Improving SME Services
Authors: Histiarini Aprisa Rian , Rachmadhani Mirga Maulana , Supriatna Intan Iriani , Pariama Yogi
Published: April 2024

Technology development is growing fast that it even encourages businesses to follow the development. The benefits of e-commerce are providing services for customers and SME competitiveness. This study aimed to analyze the benefits of E-commerce in Izdihaar, such as SMEs, by using PIECES Analysis to add marketing options and increase the variety of services for consumers. It has six evaluation variables, such as performance, information, economics, control, efficiency, and service. Thus, it found that there are weeknesess in each variable of PIECES. Hence, a design recommendation for a website E- commerce that can be used for the shop appears. This study must be carried out immediately to see the results of maximizing the utilization of e-commerse for the development of one of the SMEs in Sorong. One of them is by adding options for marketing and to increase the variety of services to consumers of covid-19 impacts. Hopefully, the website design that recommended can help the marketing and selling process of the product in Izdihaar SME.
Correlation between Deformation and Volumetric Characteristics in the Aging Condition of Hot Mix Asphalt
Authors: Trestanto Ferdinand , Hadiwardoyo Sigit Pranowo , Tambunan Hermon Frederik , Lumingkewas Riana Herlina
Published: April 2024

The surface layer of pavement structures tends to experience a decrease in performance as its service life approaches. Generally, this decrease in performance is caused by aggregate degradation and aging of the asphalt binder, which can be caused by traffic loads or weather exposure. The mechanical performance of asphalt mixtures is due to the effects of aggregate degradation, which was simulated by reducing the coarse aggregate fraction and adding medium and fine aggregate fractions. The asphalt aging process simulates changes in binder characteristics by adding RAP binder to Pen 60/70 asphalt. Hot mix asphalt (HMA) with new material (SA-1) as a control for degradation simulation (SA-2, SA-3 and SA-4). Marshall test results show that aggregate degradation significantly causes a decrease in voids in the mixture (VIM) and voids in mineral aggregate (VMA), as well as an increase in voids filled with asphalt (VFA). WTM test results show that HMA degradation causes an increase in rutting depth, which increases the deformation rate and decreases dynamic stability. The correlation results between WTM and Marshall tests show a negative exponential relationship between VIM and VMA with deformation and a positive exponential relationship between VFA and asphalt mixture deformation.
Study of Modulus of Rupture on Geopolymer Concrete Temperature Difference Methods of Steam Curing
Authors: Ujianto Muhammad , Majid Masni A. , Aulia Zakaria Sulthon , Nurchasanah Yenny , Setiawan Budi , Rochman Abdul
Published: April 2024

Geopolymer concrete is concrete without cement. Cement replacement due to cement production has resulted in a global warming effect. Fly ash as a substitute for cement is a waste of coal production containing pozzolan properties. Concrete must have reliable mechanical properties of the modulus of rupture. This research aims to study the influence of the modulus of rupture on the steam curing of geopolymer concrete-based fly ash as a substitute for cement and alkaline activator of 12 Mol NaOH: Na2SiO3 (3:1). The applied steam curing temperatures are 60oC, 70oC, and 80oC. After steam curing, the sample is stored at ambient curing and submerged in water. The sample beam is 15 x 15 cm x 60 cm to find the value of the modulus of rupture. The test results obtained a modulus of rupture concrete geopolymer steam curing temperature of 80 and ambient curing of 3.87 MPa. Steam curing of 70oC and ambient curing of 3,71 MPa. Steam curing of 60oC and the ambient curing is 2.71MPa. It can be concluded that the higher the steam curing temperature the value of the modulus of rupture is higher.
Vibration Training System Performance Test – Two Mass Absorber System Experiment
Authors: Kurdi Ojo , Satrijo Djoeli , Prahasto Toni , Yulianti Ian , Yob Mohd Shukri , Rayhan Muhammad Arif
Published: April 2024

Two mass absorber is a vibration control system designed to enhance structural stability by strategically placing additional masses to effectively absorb and dampen vibrations. This technology mitigates resonance and harmful amplitude, reducing the risks of structural failure and operational inefficiencies in diverse engineering applications. Through this innovative approach, structures can withstand dynamic forces and operate efficiently in various fields. The TM 150 unit is used for conducting various experiments related to vibration phenomena. In this paper, experiments are carried out on a flexible beam that is oscillated using an unbalanced mass in the frequency range of 6 Hz to 18 Hz to see at which frequency the flexible beam will resonate. Another variation is to provide two mass absorbers under the flexible beam to see the difference. The experimental resonance graph was produced that was in accordance with the theoretical one, but with different amplitude units due to equipment limitations. The resulting graph shows before the absorber, the flexible beam resonates at its natural frequency. Afterward, small vibrations occur at that point, while resonance shifts. Furthermore, the performance of the vibration test unit is very good in showing the phenomena that occur in accordance with the theory.
Micro Small Medium Enterprises Intention to Implement Circular Economy in Solo, Indonesia
Authors: Satriyono Raden Danang Aryo Putro , Pebrianti Dwi , Sakti Arga Seta Asmara
Published: April 2024

Indonesia’s waste problem leads to severe effect such as economic, environment and social consequences in Indonesia as second largest contributor of waste In the world. Part of the waste source in Indonesia is from micro small medium enterprise sector. One of the solution to support sustainable development goals is by implementing circular economy to combat waste. This phenomenon then can be further analysed with variables related to perception and behavior of human. This study investigates determinants of MSME's participation intention and behavior to implement circular economy for their waste in a framework that incorporates Extended theory of planned behavior (TPB). Structural Equation Modeling (SEM) then was used to analyse all the variables correlation, The results of this study are that there are 5 significant correlations between variables, namely Descriptive Norm and Attitude have a significant and negative effect on Intention to Use. This study also found that the factors Perceived Behavioral Control, Individual concern and perceived economic use had a positive and significant effect. In addition, other findings are that Perceived Usefulness and Perceived Effectiveness and perceived environmental knowledge do not have a significant effect on Intention to Use.
The rise of telemedicine services in Indonesia: What factors determine customers' repurchase intentions?
Authors: Sholihah Mar’atus , Ardana Zevano Christna , Mitake Yuya
Published: April 2024

Telemedicine is the delivery of health care services using information and communication technology. Telemedicine services began to be widely used during the COVID-19 pandemic. With the continuous rise of telemedicine platforms, it is a solid call for companies to retain customers' purchases to maintain sustainable competitiveness. Thus, this research explores factors influencing customer decisions to repurchase services in the same telemedicine platform. This study develops a conceptual model: Sales and Marketing Promotion, E-Service Quality, and Brand Image determine repurchase intention, with E- Satisfaction and Brand Trust as intervening variables. The proposed model was tested and validated in the Halodoc case study as Indonesia's most used telemedicine service, with a 46.5% market share. The data collection uses an online survey with 195 respondents who have used Halodoc services. Structural Equation Modelling Partial Least Square is used to examine the model and test the hypothesis with the help of SmartPLS 4. The results show that variables of Sales and Marketing Promotion, E-Service Quality, and Brand Image affect E-Satisfaction and Brand Trust. Meanwhile, E-Service Quality, Brand Image, E- Satisfaction, and Brand Trust affect Repurchase Intention. In contrast, the Sales and Marketing Promotion variable requires the E-Satisfaction to intervene in Repurchase Intention. This research reveals the critical determinants of customers' repurchase intentions in telemedicine in Indonesia.
Performance enhancement of Savonius wind turbine through partially deformable blades
Authors: Zereg Alaeddine , Bouzaher Mohamed Taher , Aksas Mounir , Lebaal Nadhir
Published: April 2024

In this study, we employ partially deformable blades to elevate the performance of Savonius wind turbines. The Bucket is constructed with rigid components equipped with a guidance system, resulting in continuous changes in its shape during turbine rotation. As the trailing edge of the advancing blade expands, it creates an active slot, effectively correcting the Bucket’s pressure distribution and enhancing the positive torque generated by the turbine. We employ a two-dimensional (2D) numerical model, implemented using the commercial software ANSYS-Fluent 23.0, with the governing motion equation executed through a user-defined function (UDF). This investigation explores the mechanism of performance enhancement by varying expansion amplitudes Our results, obtained at a Tip-speed ratio (TSR) of 1, reveal that when the amplitude of deformation exceeds one-quarter of the Bucket radius, the partially deformable blade outperforms the rigid blade, leading to a remarkable 32% improvement in the torque coefficient. These findings signify a promising path toward enhancing Savonius turbine efficiency.
Thyroglobulin Antibodies and Tumor Epitope-Specific Cellular Immunity
in Papillary Thyroid Cancer
Authors: Allelein Stephanie , Ehlers Margret , Thoma Taina , Mattes-György Katalin , Antke Christina , Mamlins Eduards , Muchalla Mareike , Giesel Frederik , Schott Matthias
Published: April 2024

Papillary thyroid carcinoma (PTC) is characterized by T cell infiltration and
frequently by the presence of anti-thyroglobulin antibodies (TgAbs). The role of
cellular immunity and of TbAbs in this context is a matter of debate. The aim of
our study was to correlate the presence of TgAbs, tumor epitope-specific T cells
and the clinical outcome of PTC patients. We studied n=183 consecutive patients
with a diagnosis of PTC which were treated with total thyroidectomy plus
131I ablation. During a follow-up of in mean 97 months, most of
the PTC patients had no signs of tumor relapse (n=157 patients). In contrast,
one patient had serum Tg levels above the detection limit and<1 ng/ml, two
patients Tg serum levels≥1 ng/ml and<2 ng/ml and n=23 patients had Tg serum
levels≥2 ng/ml. Morphological signs of tumor recurrence were seen in 14
patients; all of these patients had serum Tg levels≥2 ng/ml. Importantly, with
the exception of one patient, all TgAb positive PTC patients (n=27) had no signs
of tumor recurrence as the serum Tg levels were below the assays functional
sensitivities. Tetramer analyses revealed a higher number of tumor
epitope-specific CD8+T cells in TgAb positive patients compared to TgAb negative
PTC patients. In summary, we show that the occurrence of TgAbs may have an
impact on the clinical outcome in PTC patients. This might be due to a tumor
epitope-specific cellular immunity in PTC patients.
Early detection of skin cancer using AI: Deciphering dermatology images for melanoma detection
Authors: Deepa R. , ALMahadin Ghayth , C Prashant G , Sivasamy A.
Published: April 2024

This Review explores the transformative impact of artificial intelligence (AI) on the early detection of skin cancer, with a specific focus on melanoma, a potentially lethal form of the disease. Beginning with an overview of traditional diagnostic methods and their limitations, this paper delves into the evolution of AI within dermatology, emphasizing its application in image analysis and pattern recognition. A comprehensive examination of AI algorithms for melanoma detection, including machine learning and deep learning models, is provided. This Review critically assesses the performance metrics, training datasets, and comparative analyses with traditional methods. Addressing challenges such as data quality, interpretability, and ethical considerations, this paper outlines future directions, emphasizing ongoing research, algorithm improvements, and integration with clinical practices. Case studies and success stories highlight the real-world impact of AI in dermatology. This Review concludes by summarizing key findings and underlining the pivotal role of AI in revolutionizing early melanoma detection, with implications for personalized medicine and enhanced patient outcomes.
Understanding the spread of typhoid fever: Combining vaccination and sanitation methods for better public health policies
Authors: Ibrahim Alhassan , Humphries Usa Wannasingha , Mohammed Ibrahim , Zarin Rahat
Published: April 2024

Typhoid fever remains a major public health concern, affecting over nine million individuals globally each year. Mathematical modeling approaches can provide valuable insights into typhoid transmission dynamics and inform preventive strategies. In this study, we developed a compartmental model incorporating key features of typhoid epidemiology and two crucial interventions: vaccination and sanitation practices. The model stratifies the population into susceptible, vaccinated, exposed, asymptomatic infected, symptomatic infected, and recovered compartments and tracks the bacterial load in the environment. We established a disease-free equilibrium and basic reproduction number R0. We also identified the endemic equilibrium and analyzed its existence. Numerical simulations demonstrated the critical impact of enhanced sanitation and vaccination in curtailing infections. Our model underscores the need for multifaceted control measures that encompass vaccine coverage, sanitation enforcement, and healthcare capacity building to mitigate typhoid in high-risk regions. This study provides a comprehensive framework to model the intricate transmission dynamics of typhoid fever, supporting informed public health policies and decision-making.
Maintaining the health of people with and without COVID-19 during isolation: a case study
Authors: Scales Caoimhe , Tsai Ling-Ling , Whitney Sarah , Shaw Miranda , Vrklevski Lil , Carey Sharon , Hutchings Owen , Spencer Lissa , Alison Jennifer
Published: April 2024

This case study evaluated the effects of a health package (HP) of a light intensity individualised exercise program and advice on anxiety management and nutrition, on the physical and mental health of people with or without COVID-19, who were quarantined in hotels used as Special Health Accommodation and admitted to the Royal Prince Alfred Virtual Hospital, Sydney during the COVID-19 pandemic. After initial screening and consenting, participants completed three surveys: Depression, Anxiety, Stress Scale; Brief Fatigue Inventory; and the European Quality of Life 5-Dimensions 5-Levels, and were provided with the HP for the duration of their quarantine. The three surveys and a participant reported experience measure were completed prior to discharge. The HP for people in quarantine demonstrated stability of health outcomes and reduction in fatigue. Most participants reported that the HP helped them cope with isolation. Provision of a HP during quarantine could be useful to support physical and mental health.
Application of the Australian Bureau of Statistics Socio-Economic Indexes for Areas in cardiovascular disease research: a scoping review identifying implications for research
Authors: Beks Hannah , Walsh Sandra M. , Wood Sarah , Clayden Suzanne , Alston Laura , Coffee Neil T. , Versace Vincent L.
Published: April 2024

Objective To scope how the Australian Bureau of Statistics Socio-Economic Indexes for Areas (SEIFA) has been applied to measure socio-economic status (SES) in peer-reviewed cardiovascular disease (CVD) research. Methods The Joanna Briggs Institute’s scoping review methodology was used. Results The search retrieved 2788 unique citations, and 49 studies were included. Studies were heterogeneous in their approach to analysis using SEIFA. Not all studies provided information as to what version was used and how SEIFA was applied in analysis. Spatial unit of analysis varied between studies, with participant postcode most frequently applied. Study quality varied. Conclusions The use of SEIFA in Australian CVD peer-reviewed research is widespread, with variations in the application of SEIFA to measure SES as an exposure. There is a need to improve the reporting of how SEIFA is applied in the methods sections of research papers for greater transparency and to ensure accurate interpretation of CVD research.
Reversal of
C9orf72
mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision
Authors: Sachdev Aradhana , Gill Kamaljot , Sckaff Maria , Birk Alisha M. , Aladesuyi Arogundade Olubankole , Brown Katherine A. , Chouhan Runvir S. , Issagholian-Lewin Patrick Oliver , Patel Esha , Watry Hannah L. , Bernardi Mylinh T. , Keough Kathleen C. , Tsai Yu-Chih , Smith Alec Simon Tulloch , Conklin Bruce R. , Clelland Claire Dudley
Published: April 2024

Efforts to genetically reverse C9orf72 pathology have been hampered by our incomplete understanding of the regulation of this complex locus. We generated five different genomic excisions at the
C9orf72
locus in a patient-derived induced pluripotent stem cell (iPSC) line and a non-diseased wild-type (WT) line (11 total isogenic lines), and examined gene expression and pathological hallmarks of C9 frontotemporal dementia/amyotrophic lateral sclerosis in motor neurons differentiated from these lines. Comparing the excisions in these isogenic series removed the confounding effects of different genomic backgrounds and allowed us to probe the effects of specific genomic changes. A coding single nucleotide polymorphism in the patient cell line allowed us to distinguish transcripts from the normal vs. mutant allele. Using digital droplet PCR (ddPCR), we determined that transcription from the mutant allele is upregulated at least 10-fold, and that sense transcription is independently regulated from each allele. Surprisingly, excision of the WT allele increased pathologic dipeptide repeat poly-GP expression from the mutant allele. Importantly, a single allele was sufficient to supply a normal amount of protein, suggesting that the C9orf72 gene is haplo-sufficient in induced motor neurons. Excision of the mutant repeat expansion reverted all pathology (RNA abnormalities, dipeptide repeat production, and TDP-43 pathology) and improved electrophysiological function, whereas silencing sense expression did not eliminate all dipeptide repeat proteins, presumably because of the antisense expression. These data increase our understanding of C9orf72 gene regulation and inform gene therapy approaches, including antisense oligonucleotides (ASOs) and CRISPR gene editing.