bluuebunny/crossref_metadata_2025 huggingface dataset:
Commodity exports of Ukraine in the conditions of current challenges
Authors: Sozanskyy Lyubomyr Y.
Published: April 2024

The article analyzes the structure and dynamics of Ukraine's commodity exports in 2022 in monetary and weight terms by product groups and items. Exports fell in 19 out of 20 analyzed commodity groups. The structure of commodity exports of Ukraine in 2022 remained conditionally stable. Thus, the largest shares in the structure of commodity exports by commodity groups in 2021 and 2022 accounted for groups II. products of plant origin; III. 15 fats and oils of animal or vegetable origin; XV. low-value metals and products from them. The largest shares in the structure of Ukrainian exports in terms of product positions in 2022 and 2021 accounted for corn, wheat sunflower, safflower or cottonseed oil, and iron ores and concentrates. The article reveals that the dynamics and structure of exports by commodity items in monetary terms differ significantly from similar indicators in weight terms. This is explained by a significant difference between the cost of exporting raw materials and products of their processing. The export value of products of the iron ore and concentrates commodity item was 15.1 times lower than the export value of products of the pipes, tubes, and hollow, seamless profiles of ferrous metals commodity item in 2022 and 8.6 times in 2021. The author summarizes that the level of decline in Ukraine’s commodity exports in 2022 can be considered an economic achievement, taking into account the catastrophic challenges that the Ukrainian nation is struggling with, as well as in comparison with export trends in 2009 and 2014-2016. This was achieved thanks to the multifaceted, diplomatic, and organizational cooperation of the state and business, the work of the grain corridor, and the liberalization of trade with the EU. At the same time, it is worth emphasizing that the export of raw materials from a statist position constitutes the loss of potential economic benefits that could be obtained by processing these raw materials in the country.
Quantum Dots as Drug Delivery Vehicles: An Abeyant Leap in Cancer Therapy
Authors: Vohra Payaam , Chaudhari Ajinkya , Shaikh Fareed
Published: April 2024

Cancer therapy encounters challenges with conventional approaches, including issues related to poor drug solubility, stability, and non-specific targeting. Quantum dots (QDs), nanocarriers exhibiting unique electrical and optical properties, present a promising solution for targeted drug delivery in cancer management. This review focuses on QDs as nanocarriers, examining their physicochemical properties, development of "smart" nanomaterials, and surface functionalization. The utilization of semiconductor, metal, and carbon-based QDs for drug delivery and imaging applications in preclinical and clinical settings is explored. Considerations pertaining to QD toxicity, biocompatibility, and recent advancements in toxicity mitigation are addressed. The review highlights challenges such as scalability, regulatory approval, and clinical translation. While possessing substantial potential, further research is necessary to tackle these challenges. The article concludes by discussing future perspectives and opportunities for enhancing QD-based drug delivery systems, thus contributing to advancements in cancer therapy.
Targeting Potential of Zinc Oxide Nanoparticles and Finasteride-loaded Nano Lipidic Carriers-infused Topical Gel - In vitro and In vivo Skin Permeation Studies
Authors: V Sankar , Roselin R Baby , Raghavenndra S Pranav Raghavenndra , M Nithyanth , A Justin
Published: April 2024

Dear Editor
I was going through the article with the above mentioned title which seems to be novel and imperative.  Finasteride (FIN), an Inhibitor of the 5α reductase enzyme primarily utilized orally to treat androgenic alopecia, has been explored in a topical gel form. There options for treating androgenic alopecia are limited and the severe systemic adverse effects make things worse. This article highlighted lipidic nanocarriers offer numerous potential benefits like improved follicular permeability and solubility
Molecular Docking Studies of Thiazolidinediones on Receptor for Advanced Glycation End Products (RAGE)
Authors: R VIMALAVATHINI , M ELAKIYA , K HEMALATHA , N SURIYA , S SWETHASRI , S KAVIMANI
Published: April 2024

Background: Advanced glycation end products (AGE), are abnormal glycation of molecular proteins and nucleic acid, and its interaction with receptors for advanced glycation end products (RAGE) culminates in metabolic, neurodegenerative, and lifestyle disorders. Thiazolidinediones are insulin sensitizers with anti-glycation activity and are currently used clinically as anti-diabetic drugs. 
Research rationale: Studies show that thiazolidinediones also exhibit antioxidant and antiglycation activity; hence we proposed that this anti-glycation activity of thiazolidinedione may be due to its anti-RAGE action, thus preventing further RAGE-AGE interaction.
Purpose of the study: Aim of the current study is to assess In-silico anti-RAGE activity of nine thiazolidinediones namely pioglitazone, rosiglitazone, ciglitazone, darglitazone, englitazone, netoglitazone, rivoglitazone, troglitazone and balaglitazone with RAGE.
Materials and Methods: Nine thiazolidinediones namely, pioglitazone, rosiglitazone, ciglitazone, darglitazone, englitazone, netoglitazone, rivoglitazone, troglitazone and balaglitazone were downloaded from PubChem database. RAGE protein was downloaded from the PDB database. The nine thiazolidinediones were docked with RAGE protein using Auto Dock software and interaction parameters were studied.
Result: All nine thiazolidinediones showed acceptable binding energy below                       (-8Kcal/mol) with 1-5 hydrogen bonds.  Rosiglitazone exhibits the highest binding energy (-8.24Kcal/mol) with 2 hydrogen bonds for RAGE. Troglitazone exhibits the lowest binding energy (-9.95Kcal/mol) with 3 hydrogen bonds for RAGE. 
Conclusion: Thus our Insilco docking studies of thiazolidinedione derivatives with RAGE conclude that these nine thiazolidinedione derivatives exhibit anti-glycation activity by direct interaction with receptors of RAGE. Thus, this work warrants future preclinical studies to claim its RAGE receptor modulation activity.
Characterization by LC-MS/MS and Antioxidant Activity of Extract and its Different Fractions of Calotropis procera Young Leaves
Authors: Agrawal Krishn Kumar , Murti Yogesh
Published: April 2024

Objective: Plants are extremely useful as a source of medication. Calotropis procera is a plant that is used to treat a variety of illnesses in traditional medical and folklore systems. In this work, bioassay guided liquid-liquid fractionation, phytochemical and molecular spectroscopic analysis and the antioxidant activity of young leaves of Calotropis procera were evaluated.
Methods: Bioassay-guided fractionation was carried out on the basis of polarity of solvents and UV, FTIR, LCMS profiling were conducted by using the standard methods. The DPPH scavenging assay was used to determine the antioxidant activity.
Results: The extractive value for the ethyl acetate fraction was 9.14 % w/w. The Total phenolic content was highest in the water fraction 83.63±0.0788 GAE/g of dry weight of extract. UV spectroscopy was used to standardize the fractions. The Presence of various functional groups in the extract/fraction was confirmed by FTIR spectroscopy. Based on LCMS, fifty compounds were identified in the hydro-ethanolic extract/fractions. Among all the fractions, the chloroform fraction showed the greatest antioxidant properties (IC50 values=8.03 mg/mL).
Conclusion: On the basis of the result of the study it can be concluded that Calotropis procera have the potential to become a promising herb for the treatment of various ailments.
Kajian Islam Sebagai Usaha Peningkatan Akhlak Peserta Didik Di SDIT Ar Rahmah Yosowilangun
Authors: Syovinatus Sholicha
Published: April 2024

Arus perkembangan teknologi dan pengetahuan menjadikan adanya perubahan pada nilai-nilai tatanan sosial dan budaya pada masyarakat. Pola hidup masyarakat saat ini menjadisangat hedonis, materialis, dan individualis. Pendidikan merupakan bagian pokok dalammempengaruhi nilai tatanan sosial dan budaya pada masyarakat khususnya dalam hal iniadalah peserta didik. Tujuan pendidikan nasional berdasarkan nilai-nilai Islam adalahpeningkatan ketakwaan kepada Tuhan Yang Maha Esa dapat dibina melalui pendidikanagama yang intensif dan efektif. Sehingga penguatan nilai-nilai tauhid dapat menjadilandasan kehidupan dan berimplikasi pada pribadi peserta didik yang mampu menjadipengendali, penyeleksi dan penyaring segala unsur kemajuan kultural yang berkembangsaat ini. Penelitian ini bertujuan untuk menggambarkan kajian Islam sebagai usaha dalammeningkatkan akhlak peserta didi di SDIT Ar Rahmah Yosowilangun. Penelitian inimenggunakan metode kualitatif dengan pendekatan studi kasus. Pengumpulan datadilakukan dengan wawancara, observasi, dan dokumentasi. Berdasarkan hasil penelitianadanya kajian Islam di SDIT Ar Rahmah Yosowilangun, tingkat kesadaran siswa akanpentingnya menjalankan Islam secara kaffah, kedisplinan dan tanggung jawab, moral dantingkah laku kepada guru dan teman-temannya mengalami peningkatan dan memilikidampak terhadap pengembangan diri (akhlak)
Design of Transfer Learning based Deep CNN Paradigm for Brain Tumor Classification
Authors: Bhardwaj Neha , Sood Meenakshi , Gill Ss
Published: April 2024

Brain tumor is a fatal illness causing worldwide fatalities. The existing neuroimaging modalities to detect brain tumors are invasive and are observer-biased. Automatic CAD frameworks using sophisticated AI techniques lessen human intervention and can effectively handle large amounts of data. Automatic CAD frameworks using Machine learning techniques require the use of time-consuming and error-prone manual feature extraction procedures. Deep learning techniques involve automatic feature extraction; hence, appreciable classification results are attained quickly. However, training DL models from scratch takes a significant investment of time, money, and large datasets, which are difficult to attain in the medical domain. Therefore, the trade-off is utilizing the well exhaustively learned models like VGG16, VGG19, AlexNet, etc. to design a novel framework for the classification of brain tumors. The paper aims to develop a CNN-based deep learning framework by fine-tuning the pre-trained VGG16 architecture via transfer learning for brain tumor detection. The designed framework employing the transfer-learning technique gives better results with less data in less time. The brain tumor binary classification using brain MR images using transfer learning achieved an appreciable accuracy of 97%. The training and validation accuracy obtained was 100% and 97%, respectively, with 30 epochs. The loss for classification was as low as 0.0059% and the run time of 32ms/step time, much less than the existing models.
A case report on incidentally detected A2B blood group
Authors: Afroz Tamanna , Mukti Menoti Paul , Saleh Abu Jafar Mohammed
Published: April 2024

The two primary subgroup of AB is A1B and A2B. A2B is extremely rare. The differentiation between A1B and A2B is based on the reactivity of A1 cells with anti- A1 lectin. Subgroups can result from inheritance of rare alleles at ABO locus and can cause discrepancy but rarely cause haemolytic transfusion reaction. Most of the subgroups are found incidentally during a pre transfusion testing or pregnancy follow up. Here we report an incidental case of A2B in a 28-year female. The case report highlights the need to be aware of such uncommon and rare blood groups. It also emphasizes on the need to do both forward and reverse grouping routinely.
A few remarks on the interpretation of Niels Bohr's philosophy-physics in Karen Barad's agential realism
Authors: Paramonov A.A.
Published: April 2024

The article deals with the approach to understanding science and technology as well as natural and cultural practices developed by the American philosopher Karen Barad in the concept of agential realism. The peculiarity of her approach consists in referring as a starting point to quantum mechanics in its interpretation, which was proposed by Niels Bohr. Barad proposes a reinterpretation of Bohr's propositions through revealing their ontological content. In this regard, the article addresses the epistemological and ontological problems that quantum physics has faced, such as the conditions for the possibility of an objective description of the world, the nature of measurement, and the relationship between language and the material world. Discussed is the shift that Barad argues is asserted in Bohr's philosophy-physics, which consists of quantum mechanics moving from the linguistic concepts in which the world of classical science was represented to what Barad calls material-discursive practices through which the world is articulated and explained. The possibilities of a different interpretation of Niels Bohr's philosophy-physics are considered.
On the criticism of culture as a value
Authors: Ogurtsov Alexandr
Published: April 2024

Speech in the publication of A.P. Ogurtsov talks about the contemporary understanding of culture by M. Heidegger, which testifies to the spiritual fall of the world and the replacement of the concept of “spirit” with the concept of “culture” in a specific meaning — as a value, which Heidegger considers “the highest sacrilege”, because God appears among the values. This understanding of culture is associated with “the secularization of thought and the oblivion of being; value thinking is rooted in the will to power”. It is significant that in our time it is not uncommon to understand culture as a value.
The evolution of physics:
from the action of forces to the power of action
Authors: Tomilin K.A.,
Published: April 2024

At the beginning of the study of physical phenomena, the idea of "force" was widely used to explain the non-stationarity of observed phenomena, such as the movement of bodies. However, as mechanics and physical theories developed, the force notions gained own formal definitions and names, without the use of the term "force". So, the concept of kinetic energy arose instead of "vis viva", and "current" instead of "current strength" ets. Additionally, a number of new physical theories have been formulated without the use of force concept. As a result, different types of forces have gradually been replaced by other more important concepts, such as energy and action, which are closely linked to fundamental physical principles. It is interesting to note that the general trend in the development of civilizations has been a shift from unrestricted power (expressed in the thesis "might makes right") to its subordination and incorporation into a legal framework. This is similar to the evolution of physics, which has seen the notion of force become eliminated or subordinated to more general principles and laws.
Voices and Numbers:
Spiritual aspects of IT Humanities
Authors: Kolesnikov S.A.,
Published: April 2024

The article examines the situation of the presence of virtual voices in modern reality. The voices of virtual assistants model a new relationship between voice and face, with anonymity and depersonalization being a priority. The closeness of the face from the voice peculiar to virtual assistants, the detachment of the voice from the facial "accompaniment", the fundamental possibility of the existence of a voice without a face — all this gives the voice as an anthropological and cultural phenomenon of modernity fundamentally new parameters. Digital "logic" implies a departure from the human logos, which can be clearly seen in the example of the problem of "gender" of artificial assistants. Special attention is paid to the problem of correlation of voice and artificial intelligence. Artificial intelligence as an organizational form of cognition acquires a voice, merges with a voice, becomes a voice. The universal scale of the claims of virtual voices requires theological reflection, because the religious experience of "working" with voices, represented in a wide range of world religions, is able to offer a unique interpretation of the role of the voice in modern times. Internet voices can be called into the liturgical space, where they will be asked to sound in new registers and keys. Digital religion appears as a new liturgical reality, a new common cause. It is significant that the non-spiritual technogenic environment can only offer emptiness — the emptiness of digital dehumanization. Digital-humanitarian unity can be built on the adoption of a spiritual foundation, based on the conclusion of a "pact" on cooperation between the spiritual experience of mankind and cyber-information perspectives.
Хирургическая конструкция стомы у детей: обзор литературы
Authors: Әшірбай К.С. , Джумабеков А.Т. , Кусаинов А.З. , Алтынбаева Г.Б. , Айтбаева Э.Б.
Published: April 2024

Актуальность: Кишечная стома является неотъемлемой частью лечения 30–50% у детей важный этап в хирургическом лечении колопроктологического профиля. Ни одну реконструктивную операцию на промежности невозможно представить без формирования кишечной стомы. При врожденной (атрезия ануса, болезнь Гиршпрунга, врожденный мекониальный илеус, врожденная аномалия толстого кишечника, атрезия тонкий кишки, из этих врожденной патологии на первом месте пороки аноректальной области занимает – 48%) и приобретенной (язвенный колит, болезнь Крона, диффузный полипоз, гнойно воспалительных процессах в области промежности, параректальные свищи, перфорация полого органа травмы промежности и некротизирующий энтероколит) хиргических патологиях желудочно-кишечного тракта оперативное вмешательство часто заканчивается наложением кишечных стом на разные отделы кишечника. Это связано с тем, что зачастую невозможно выполнить одномоментную радикальную коррекцию. Осложнения кишечных стом встречаются у 21-75% пациентов, среди них от 16 до 36% больных со стомами требуют повторных вмешательств из- за эвентрации, эвагинации, ретракции выведенной стомы. Таким образом, наложение брюшинно-апоневротического кольца является оптимальным методом для решения вышеизложенных осложнений за счёт лучшей фиксации кишечной стомы и предотвращения спаечных процессов.Цель исследования – проведение анализа современных данных литературы по наложению стом у детей с врожденной и приобретенной хирургической патологией.Материалы и методы: Поиск публикаций глубиной 10 лет осуществляли в реферативных базах РИНЦ, PubMed и Scopus по ключевым словам: стома, дети, новорожденные, осложнения стомы, хирургическая конструкция, хирургическое лечение. Найдено 103 публикаций, для анализа было отобрано 43 исследований.Результаты: Таким образом, в подавляющем большинстве случаев формирование кишечной стомы в детской практике носит временный характер и подразумевает последующее восстановление проходимости кишечника, что имеет решающее значение при выборе вида кишечной стомы и техники ее формирования. Перистомальные осложнения. Правильно сформированная стома должна выполнять свои функции, не усугубляя, а облегчая состояние больного ребенка. Однако кажущаяся простой на первый взгляд операция – наложение кишечной стомы – может сопровождаться различными техническими погрешностями и ошибками, что приводит к широкому спектру осложнений – от минимальных до тяжелых, с угрозой жизни пациента.Заключение: Исходя из вышеизложенного, необходимо проведение дальнейших исследований с целью исключения осложнений, а также быстрого восстановления в раннем послеоперационном периоде стомированных детей с внедрением новых способов наложения стом с созданием брюшинно-апоневротического кольца у детей раннего возраста.
HRAS онкобелокпен байланысты сүт безі қатерлі ісігінін клиника-морфологиялық критерийлері
Authors: Жумакаева А.М. , Иманбаева Г.Н. , Стабаева Л.М. , Кабилдина Н.А. , Ныгызбаева Р.Ж. , Жумакаева С.С. , Турдыбекова Я.Г.
Published: April 2024

Өзектілігі: Зерттеушілердің Харви саркома вирусын жұқтырған онкоген (HRAS) геніне деген қызығушылығы сүт безі қатерлі ісігі кезінде берілген геннің экспрессиясының жоғарылауын анықтау нәтижесінде өсті. Белсендірілген Ras формалары эпидермиялық өсу факторының рецепторы (EGFR) немесе HER2 экспрессиясы болған кезде сүт безі қатерлі ісігінде де жасуша желілерінде де жоғарылайды. Демек, Ras тікелей мутациялық белсенділігі болмаған кезде сүт безі ісіктерінде белсендірілуі мүмкін және жағдайлардың 20-50% жетеді. Экспрессияны тежеу HRAS–тан ядроға сигнал беру жолдарын үзу перспективті терапевтік тәсіл болуы мүмкін.Зерттеудің мақсаты – ерте диагностиканы жақсарту үшін фарнезилтрансфераза ингибиторымен емдеудің әртүрлі режимдерін қабылдаған емделушілерде жергілікті прогрессивті сүт безі қатерлі ісігінің клиникалық және морфологиялық критерийлерін және HRAS онкобелок экспрессиясын зерттеу.Материалдар мен әдістері: Жергілікті дамыған сүт безі қатерлі ісігі диагнозы қойылған 100 науқастан тұратын топ 2016 жылдың қаңтары мен 2019 жылдың ақпаны аралығында қабылданды. Олардың жасы 29-дан 78 жасқа дейін өзгерді, ал орташа жасы 59± болды. HRAS онкоақуыздардың иммуногистохимиялық экспрессиясын анықтау.Нәтижелерi: HRAS экспрессиясы мен Her2/neu экспрессиясы (р=0,001), сондай-ақ сүт безі қатерлі ісігі бар науқастарда ki-67 ісік пролиферациясының индексі (р=0,001) арасында байланыс анықталды. HRAS экспрессиясы арасындағы байланысты талдау емдеуге дейін (V=0,47; p=0,001) және емдеуден кейін (V=0,45; p=0,001) прогрессиясыз өмір сүрумен салыстырмалы түрде күшті байланысты көрсетті.Қорытынды: Бұл нәтижелер HRAS-тың сүт безі қатерлі ісігінің болжамды факторы немесе емдік мақсаты ретінде клиникалық қолданылуын көрсетуі мүмкін.
Оценка влияния витамина Д на предменструальный синдром у девочек-подростков с первичной дисменореей
Authors: Кульжанова Д.С. , Нургалиева Р.Е. , Донаева А.Е. , Станкевичюс Э. , Тубулбаева С.А. , Аманжолкызы А.
Published: April 2024

Актуальность: Изученные публикации по проблеме предменструального синдрома (ПМС) у девочек-подростков и молодых женщин указывают о применении различных биологически активных добавок перед менструацией для облегчения ПМС. Тем не менее, параллельно исследованиям, где отражены положительные эффекты влияния витамина D, встречаются работы, не подтверждающие такие взаимосвязи. Для детализации и подтверждения эффективности или неэффективности приема витамина D, для доказательства возможной необходимой дозировки витамина D и долгосрочности эффективности приема витамина D необходимы дополнительные исследования.Цель исследования – оценка влияния витамина D на характер ПМС у девочек-подростков с первичной дисменореей (ПД).Материалы и методы: Исследование выполнено в Областном перинатальном центре в городе Актобе, Казахстан. В исследование были включены 191 девочек-подростков с ПД. Методом случайных чисел участники были распределены на две группы: основная группа 96 девочек-подростков, получавшая витамин D, и контрольная группа 95 девочек-подростков, получавшая плацебо. В начале и после трех месяцев обследования у всех девочек-подростков проведено анкетирование для выявления признаков ПМС и определен уровень 25(OH) витамина D в сыворотке крови.Результаты: Среди обследованных девочек-подростков с первичной дисменореей и ПМС более 70% характеризуются дефицитом по уровню витамина D в организме. В основной группе после исследования было выявлено статистически значимое повышение содержания витамина D (p<0,001). Вначале распространенность ПМС среди девочек-подростков с ПД в основной группе составляла 51,7%, после приема витамина D это значение снизилось до 23% (p<0,001). В контрольной группе случаи ПМС в последовательности до приема плацебо и после увеличились с 35% до 42,5%.Заключение: Прием витамина D в течение трех месяцев достоверно улучшает изученные признаки ПМС среди девочек-подростков с первичной дисменореей, кроме того, достоверно улучшает течение менструального цикла, в частности, по нормализации длительности менструации в днях и обильности выделений.
Rare Case of Primary Effusion Lymphoma mimicking Pulmonary Tuberculosis
Authors: Idris Dewinsya Medisujiannisa , Gubali Winansih
Published: April 2024

Primary effusion lymphoma (PEL) is a rare large B-cell non-Hodgkin lymphoma (NHL) that usually occurs in immunosuppressed individuals in advanced stages of the disease, presenting as body cavity effusions without detectable tumor mass. We report a 61-years old man presented to the emergency room complaining of effort-related dyspnoea, low-grade fever, night sweats, and a dry cough for several days. He was then put on empirical anti-tubercular treatment (ATT) suspecting Pulmonary Tuberculosis. General examination revealed a decrease oxygen saturation, tachypnea, a bulging tenderness lymph node on the neck. Chest computerized tomography (CT) scan indicated pericardial and pleural effusion with mediastinal dilatation suspected thymoma or lymphoma. A Cardiocentesis needle aspiration was performed; however, the histological pattern was not specific. The patient underwent a surgical biopsy of a left supra-clavicular lymph node. A Classical Hodgkin lymphoma nodular sclerosis type was found in the histopathology examination. Immunohistochemistry detected the tumour cellular markers (i.e., CD30). Chemotherapy treatment for 6 cycles resulted an excellent outcome. In conclusion, radiologists play a vital role in the diagnosis of PEL, detecting effusions in body cavities and excluding the existence of solitary masses or pleural nodules or masses, ultimately narrowing down the differential diagnoses.
An Overview of The Risk Factors for Patients with Inguinal Hernia at Aloei Saboe Hospital in Gorontalo
Authors: Potutu Aliffa Cahya , Abdul Romy , Kasim Vivien Novarina A. , Pateda Sri Manovita , Daud Serly
Published: April 2024

Introduction: Hernias happen when an organ or tissue bulges through a weak  point in the abdominal wall. Inguinal hernias are common and may need surgery.  The present study report the overview of the risk to affect the inguinal hernia at  Aloei Saboe Hospital.Method: The research focused on patients with inguinal hernias who underwent  examinations at Aloei Saboe Hospital, in Gorontalo Province from January to  December 2022. The study used the total sampling technique, with a sample size  of 42 individuals. It was conducted in September and October 2023 at the same  hospital.Results: The data indicates that a significant portion of patients in the range of age  56-65 years (28.6%), with a majority being male (85.7%). Additionally, the  majority of patients who were not employed (19.0%) were also found to have this  condition, as well as a vast majority of those with a primary diagnosis of inguinal  hernia (88.1%).Conclusion: Most patients with inguinal hernia at Aloei Saboe Hospital are males  in the late elderly age group who are no longer working. The main diagnosis for  most patients is inguinal hernia. The study's findings suggest that the hospital can  enhance its system, particularly in archiving medical records or electronic medical  forms, to serve its patients better. Key words: Gorontalo, hernias, inguinal hernia
DIGITAL STATISTICS AS A MEANS OF LANGUAGE MANIPULATION IN THE MEDIA
Authors: Журавлев Д.М.
Published: April 2024

В современную эпоху информационных войн средства массовой информации (СМИ) ищут эффективные средства манипулирования массовым сознанием реципиентов. Одним из таких средств манипуляции является цифровая статистика. Цель настоящего исследования состоит в определении роли цифровой статистики как средства языкового манипулирования в современных СМИ. Формируемые статистикой информационные данные дают точное описание происходящих событий. Статистические данные обладают такими свойствами, как актуальность, наглядность, конкретность и официозность, что придает им особое значение в системе средств массовой информации. Вероятность принятия за истину сомнительной информации, размещенной в СМИ, возрастает, если закрепить за ней статистические данные. Потому цифровая статистика рассматривается как один из самых мощных инструментов воздействия на человека. В статье анализируется вопрос языкового манипулирования в свете цифровой статистики в русскоязычных и англоязычных СМИ. Обозначены сферы жизнедеятельности людей, в которых более всего используется манипулирование цифровой информацией.

In the era of information wars, modern mass media are looking for effective means of manipulating the mass consciousness of recipients. One of such means of manipulation is digital statistics. The purpose of the study is to determine the role of digital statistics as a means of language manipulation in modern media. The information data generated by statistics gives an accurate description of the events taking place. Statistical data have such properties as relevance, visibility, concreteness and officiousness, which give them special importance in the system of mass media. The probability of accepting dubious information posted in the mass media as the truth increases if statistical data is attached to it. Therefore, digital statistics is regarded as one of the most powerful tools to influence people. The article analyzes the issue of language manipulation in the light of digital statistics in Russian- and English-language media. The spheres of human activity in which the manipulation of digital information is most used are indicated. Digital statistics is understood as one of the means of language manipulation in the media. The role of digital statistics and its impact on the addressee is determined.
ALLEVIATING SURVEYOR BIAS IN REAL ESTATE: AN APPLICATION TO VACANCY AND PROPERTY PRICES
Authors: Lee Changro
Published: April 2024

Although vacancies in the real estate market have always been of key interest to both private and public stakeholders, measuring the impact of vacancy rates on property prices is challenging. This study attempts to quantify the extent of the influence of vacancy rates on the price decline of commercial properties. The dataset used in this study was collected and collated by valuation experts. We attempt to alleviate the bias inherent in the price estimates provided by the surveyors. A Bayesian multilevel estimation model was employed, and the results revealed that while some experts do not show deviations from the standard tendency of a peer group, others do diverge from this norm. Based on these findings, a bias-controlling price decline rate was derived. As many real estate statistics are produced based on survey data compiled by experts, the approach adopted in this study is expected to be applied to various real estate practices to mitigate the inherent and inevitable surveyor bias.
ROBUST OPTIMIZATION MODEL OF CONTAINER LINER ROUTES IN FEEDER LINE NETWORK
Authors: Huang Xiaoling , Chen Huanping , Zhang Jiaan , Wang Dan , Chen Jihong , Luo Jack Xunjie
Published: April 2024

The universal application of the hub-and-spoke maritime network makes feeder line network key to restricting the quality and efficiency of maritime transportation. However, container liner routes in feeder line network are susceptible to the changes in shipment demand and international fuel prices. Therefore, based on the hub-and-spoke maritime network, this paper constructs a robust optimization model of container liner routes in feeder line network. Under the capacity and time constraints, routes optimization and ship equipment under uncertain environment are analysed. An improved tabu search algorithm was designed based on the characteristics of the model. The example analysis proves that the model can still ensure the robustness of routes under uncertain environment, which is more applicable than the deterministic model.
New Light on Dark Extended Lenses with the Roman Space Telescope
Authors: DeRocco William , Smyth Nolan , Takhistov Volodymyr
Published: April 2024

The Roman Space Telescope’s Galactic Bulge Time Domain Survey will constitute the most sensitive microlensing survey of the Galactic bulge to date, opening up new opportunities to search for dark matter (DM). Many extensions of the Standard Model predict the formation of extended DM substructures, such as DM subhalos, boson/axion stars, and halo-dressed primordial black holes. We demonstrate that for such targets, Roman will be sensitive to a broad parameter space up to 4 orders of magnitude below existing constraints. Our analysis can be readily applied to other extended DM configurations as well.
Satellite Visibility During the 2024 April Total Eclipse
Authors: Lawler Samantha M. , Rein Hanno , Boley Aaron C.
Published: April 2024

On 2024 April 8, tens of millions of people across North America will be able to view a total solar eclipse. Such astronomical events have been important throughout history, but with nearly 10,000 satellites in orbit, we question whether total eclipses will now reveal a sky full of satellites, fundamentally changing this experience for humanity. Using the current population of Starlink satellites, we find that the brightest satellites would be naked-eye visible in dark skies, but the high sky brightness during totality will make them undetectable to the unaided eye. Our model does not take into account the effects of chance reflections from large, flat surfaces like solar panels, which we expect will cause glints and flares that could be visible from large satellites and abandoned rocket bodies. Time-lapse all-sky imaging might reveal satellites during the eclipse.
Estágio curricular supervisionado em ciências e biologia: compreensões de licenciandos e professores-orientadores
Authors: Garda Carla Munique Aparecida , Wirzbicki Sandra Maria , Tobaldini de Lima Bárbara Grace
Published: April 2024

A pesquisa aborda a temática Estágio Supervisionado, que pode ser compreendido como uma etapa de formação e preparação para o exercício da profissão. O estudo objetiva conhecer as concepções que os licenciandos e professores-orientadores dos estágios supervisionados do curso de Ciências Biológicas da Universidade Federal da Fronteira Sul, Campus Realeza-PR, possuem em relação aos estágios, além de compreender como os licenciandos concebem a figura desse professor e supervisor de estágios. Considera-se importante conhecer essas compreensões, pois a prática do estágio pode gerar reflexos na ação docente por parte do futuro professor e do professor que orienta os estagiários. A coleta de informações deu-se a partir de um questionário com os licenciandos que haviam cursado as disciplinas de Estágio Curricular Supervisionado (ECS) em Ciências I e Biologia I, considerando que para a realização do ECS em Biologia I o licenciando precisa ter cursado ECS em Ciências I e II, e uma entrevista com os orientadores de estágio. A análise dos dados baseou-se na Análise Textual Discursiva, a partir da qual foram organizadas duas categorias mistas: I) Estágio Curricular Supervisionado: um momento de Formação, partilha de experiências e reflexão sobre a prática. II) Professores orientadores e supervisores: sujeitos fundamentais na relação entre as duas instituições formadoras. Tais categorias permitiram pensar sobre a importância de conceber o estágio como um momento de formação reflexiva e sobre a necessidade de um maior envolvimento entre universidade e escola, possibilitado pela aproximação entre os citados docentes e supervisores.
A ACTIO em tempos de mudanças estruturais nas produções científicas
Authors: Lambach Marcelo , Gonçalez Mirian Maria Andrade
Published: April 2024

Editorial para o Volume 8 número 3 da ACTIO: docência em ciência
A Educação Digital na formação de Pedagogos: um mapeamento da produção científica brasileira (2015 a 2021)
Authors: Jesus Jolúcia Santos de , Vilas Boas Maria Cristina Xavier Reis , Santos Valdeir Almeida , Souza Ana Paula Gestoso de
Published: April 2024

A educação digital é voltada para formação do cidadão que seja capaz de utilizar as ferramentas tecnológicas em seu dia a dia com ética e responsabilidade. Com esse intuito, é necessário que os cursos de formação de professores invistam na qualificação profissional para o uso das tecnologias, visto ser uma demanda da sociedade contemporânea. A atuação do pedagogo vem sofrendo bastante impacto devido à incorporação das tecnologias nos anos iniciais do Ensino Fundamental. Assim, este estudo buscou analisar o que a produção científica brasileira vem publicando sobre a formação do pedagogo no contexto da Educação Digital. Como caminho teórico-metodológico, optou-se pela pesquisa bibliográfica, para por este meio, mapear as produções científicas num período determinado de seis anos (2015 a 2021). Como resultados, foram selecionados seis (6) artigos, publicados no Portal de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Os dados foram analisados seguindo os pressupostos metodológicos da análise de conteúdo a partir de três categorias: os referenciais teóricos predominantes nas pesquisas que abordam a Educação Digital na Pedagogia; as temáticas que emergem das produções científicas brasileiras no campo da Pedagogia que problematizam a Educação Digital na formação de professores; as concepções de tecnologia e educação digital presentes na formação do pedagogo. Concluiu-se que a formação docente deve estar alicerçada na utilização da Educação Digital que permita a construção colaborativa de saberes, principalmente, na formação do pedagogo.
Qualidade de vida de pacientes oncológicos
Authors: Lima Thyara Maria Stanley Vieira , Rodrigues Claudeneide Araujo , Carvalho André Rodrigues , Santos Jueline Da Silva , Ferreira Luana Gabrielle de França
Published: April 2024

OBJETIVO: Avaliar a qualidade de vida de pacientes oncológicos hospitalizados, caracterizando os domínios da qualidade de vida e verificando os fatores associados.MÉTODOS: Trata-se de uma pesquisa do tipo transversal, observacional e quantitativa, realizada com pacientes com câncer internados em um hospital público de Teresina/PI. Foram coletados dados por meio de ficha elaborada sobre características sociodemográficas e clínicas e pelo instrumento genérico de avaliação da qualidade de vida WHOQOL-Bref. Foi realizada análise comparativa (Kruskal-Wallis) e foi considerado nível de significância de 5% (p<0,05).RESULTADOS: Participaram da pesquisa 93 pacientes, 77,4% do sexo feminino, com média de idade de 50,6±15,6 anos e 57,0% eram do interior do Piauí. Quanto ao diagnóstico, 24,7% apresentaram diagnóstico de câncer de colo de útero. Além disso, 29,0% encontravam-se em pós-operatório. Quanto ao estadiamento, 39,8% estavam no estádio 1 mostrando que descobriram a doença precocemente. Na avaliação da qualidade de vida obteve-se na qualidade de vida geral, a média de 2,71. Verificou-se que os domínios mais comprometidos foram os domínios psicológico (média: 3,06) e físico (média: 3,13) e o mais preservado, o domínio meio ambiente (média: 3,40). Os pacientes em situação de pós-operatório apresentaram melhor condição de qualidade de vida geral (p=0,053) e domínio psicológico (p=0,044). Além disso, os pacientes oncológicos em estadiamento 1 apresentaram melhor situação nas relações sociais (p=0,013).CONCLUSÕES: Os pacientes, de forma geral, tiveram pior percepção dos domínios psicológico e físico e melhor percepção do domínio meio ambiente. O estadiamento da doença e a situação de pós-operatório repercutiram na percepção da qualidade de vida.
Correlação entre medidas antropométricas e qualidade de vida de idosas praticantes de exercícios físicos
Authors: Souza Welligton Chaves de , Lopes Neto David , Melo Thiago Souza de , Oliveira Rachel Trindade , Lima Renan Gonçalves , Araújo Roberto Santos de
Published: April 2024

OBJETIVO: Correlacionar medidas antropométricas e qualidade de vida de idosas praticantes de exercícios físicos.MÉTODOS: Estudo do tipo transversal quantitativo, constituído por uma amostra de 82 idosas. A qualidade de vida foi estimada por meio da aplicação do instrumento Short-Form Hearth Survey (SF-36). As medidas antropométricas usadas foram massa corporal, estatura, circunferência da cintura e do quadril, índice de massa corporal, relação cintura-quadril e índice de adiposidade corporal. Correlações com nível ≥0,20 (p<0,05) foram inseridas em modelos de regressão logística com base na teoria de modelos lineares generalizados. A modelagem das covariáveis foi realizada por método de Stepwise Backward. A normalidade dos resíduos foi verificada por teste de Shapiro-Wilk. Para comparar os diferentes modelos foi usada a análise da variância. Para definir o modelo mais ajustado foi aplicado a regressão logística na família exponencial de Poisson e Binomial Negativa.RESULTADOS: Foram identificados seis modelos de regressão logística que demonstraram maior qualidade de ajuste. Dentre esses modelos, destacou-se nas idosas com idade de 60 a 69 anos, a relação que: quanto menor a estatura, a circunferência do quadril, o índice de adiposidade corporal e maior a circunferência do quadril melhor a saúde mental.CONCLUSÕES: Existem correlações significativas entre as medidas antropométricas e os domínios da qualidade de vida de idosas praticantes de exercícios físico.
Adolescent HIV Screening and Opt-Out Testing as a Standard of Care
Authors: Orionzi Bako
Published: April 2024

Despite the significant steps made in the diagnosis and treatment of HIV, there is still a notable amount of people living with HIV without being diagnosed, with a fair portion of these infections occurring in adolescents and young adults. For some individuals, by the time they are diagnosed they are living with advanced-staged disease, missing the opportunity for receiving antiretroviral treatment that would have markedly reduced their morbidity, mortality, and risk of transmission to others. Opt-out testing, or notifying the patient the test will be performed unless explicitly declined or deferred, increases the rates of testing while reducing the stigma of the disease. It is a universal recommendation for those between ages 13 and 55 years to have an HIV screening test. It should be standard of care for HIV tests in the adolescent population to be structured as an opt-out screening in both the ambulatory and acute care settings.

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Pediatr Ann
. 2024;53(4):e111–e113.]
Infantile Hemangiomas and Vascular Anomalies
Authors: Paradiso Michela M. , Shah Sonal D. , Fernandez Faith Esteban
Published: April 2024

Vascular anomalies represent a diverse group of disorders of abnormal vascular development or proliferation. Vascular anomalies are classified as vascular tumors and vascular malformations. Significant advances have been made in the understanding of the pathogenesis, natural history, and genetics of vascular anomalies, allowing for improvements in management including targeted molecular therapies. Infantile hemangiomas are the most common vascular tumor of childhood and follow a distinct natural history of proliferation and involution. Although benign, infantile hemangiomas can be associated with important complications. The use of beta-blockers has revolutionized the management of infantile hemangiomas. Other vascular tumors include pyogenic granulomas, congenital hemangiomas, and kaposiform hemangioendotheliomas, among others. Vascular malformations are categorized based on the type of involved vessel, including capillary malformations, venous malformations, lymphatic malformations, arteriovenous malformations, and mixed vascular malformations. Expert multidisciplinary management of vascular anomalies is critical to optimize outcomes in these patients.

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Pediatr Ann
. 2024;53(4):e129–e137.]
Pediatric Acne Vulgaris: A Guide for Recognition, Examination, Referral, and Treatment
Authors: Scott Jennifer B. , Allen Natalie G. , Zaenglein Andrea L.
Published: April 2024

Acne is a common skin condition in adolescent patients but much less common in childhood. Pediatric providers should be familiar with the varying presentations in the pediatric population and recognize when additional physical signs of hyperandrogenism are present. This article details the pathogenesis and presentation of acne in infancy, mid-childhood, and preadolescence. The differential diagnosis is discussed and recommendations for initial workup, referral, and treatment are provided.

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Pediatr Ann
. 2024;53(4):e115–e120.]
“To Become a Devil”: Special Effects, Magic Tricks, and the Technological Image in Faust
Authors: Shubert Amanda
Published: April 2024

This essay argues that F.W. Murnau’s Faust (1926) advances a philosophy of film as a medium for “technological images”—images that are technologically constructed special effects such as double exposure and substitution splice. By portraying Mephistopheles as a conjurer, the film explores cinema’s place in the history of visual and technological magic.
Intracellular Molecular Pathways and the Biosystems that Arise from Them: An Ontological Investigation
Authors: Stein Ross L.
Published: April 2024

The cell’s ability to metabolize foodstuffs, synthesize proteins and nucleic acids, and transduce extracellular signals, all rely on an intricate intracellular network of biological systems. These biosystems are the dynamic manifestations of the molecular pathways that define them and arise when these molecular pathways are activated. In this paper, I ask if the transformation from pathway to biosystem (abbr., bioSip, for intracellular pathway biosystem) is accompanied by a change in ontological status, and if so, what this new status is. After introducing key biochemical concepts, including the difference between pathway and biosystem, and the concept of enzyme coupling that transforms an ensemble of enzymes into a bioSip, I analyze the ontological status of bioSips, specifically asking if the empirical data support the view that bioSips exist in nature as ontological unities, as actualities. I conclude that certain highly structured bioSips, known as metabolons, are indeed actualities. Finally, I explore the metaphysical foundations for the ontological unity of metabolons, considering three metaphysical systems that emphasize the dynamic and relational nature of reality: process philosophy, Aristotelian-Scholastic substance philosophy, and Ivor Leclerc’s philosophy of nature.
Does Technology Drive Supply Chain Visibility?
Authors: John Paul Raj V (44735c3a-ef57-4fe9-9689-58249c61c99a  , Varshitha Kotapati , Pachiyappan Sathish , Vellaiyan Saravanan
Published: April 2024

Success and efficiency of today's business depends on many factors across various industries. Among the many factors, supply chain plays a crucial role. The well-functioning of distribution system may lead to customer satisfaction, cost reduction, risk management, competitive advantage, collaboration and integration, innovation and adoptability and sustainability. Adopting technology in supply chain systems is another way of increasing business growth in the present era. The technologies used in today's business organizations are blockchain, internet of things (IoT), cloud technology, etc. To what extent technology is used to improve supply chain visibility in business is a matter of concern. With this background, the study aims to explore the relationship and impact of different technology on supply chain visibility in fast moving consumer goods sector. To meet the objective of the study, the study chose the top 20 FMCG companies based on highest market share and collected the data from 20 supply chain managers. The variables considered for the study were internet of things (IoT), blockchain, artificial intelligence (AI), radio frequency identification (RFID), cloud technology and information technology. relevant statistical analysis was used to prove the results and it is evident that technology positively correlates with the supply chain visibility. Artificial Intelligence has the most significant impact on the supply chain visibility of a firm. Hence, there is a significant impact of technology on supply chain visibility and the extent impact is high.