bluuebunny/crossref_metadata_2025 huggingface dataset:
Urachustumort utánzó hasi actinomycosis
Authors: Szűcs Enikő , Lukács Nándor , Budai Annamária , Seres Erika , Sikorszki László , Árgyelán János , Cserni Gábor
Published: November 2022

Összefoglaló. Az urachus tumorai és egyéb betegségei ritkák. A 67
éves férfi anamnézisében ismétlődő húgyúti fertőzés szerepelt
ciprofloxacinterápiával. Cisztoszkópia során a húgyhólyag felső részének
másodlagos érintettségére utaló bullosus nyálkahártya képe mutatkozott. Az ezt
követő CT-felvételek alapján az alsó medián hasfallal, húgyhólyaggal, belekkel
összefüggő tumor iránydiagnózisát állították fel. A kivizsgálás során kialakuló
ileus miatt Hartmann-műtétet végeztek, a tumoros jellegű elváltozás teljes és az
érintett szervek részleges eltávolításával. A kórszövettani vizsgálat daganatos
elváltozást nem talált, hasi, vélhetően urachuseredetű actinomycosist igazolt:
erre az eredetre a lokalizáció és a tünetek közt szereplő köldökváladékozás
alapján lehetett gondolni, annak ellenére, hogy urachusmaradványt szövettanilag
nem sikerült igazolni a mikroabszcedáló gyulladás által érintett szövetekben. A
betegnél amoxicillinterápia indult. Átmeneti, hólyag melletti vizeletcsorgást
követően a beteg tünet- és panaszmentesen távozott a kórházból, de 13 nappal
később a hasfali seb sterilnek véleményezett szétválása miatt ismét
hospitalizálni kellett. Negatív nyomású sebkezelést követően sikerült a hasat
ismét zárni. A beteg ismét tünetmentessé vált, és fenntartott
antibiotikumkezelés mellett hagyta el a kórházat. Az urachuskörnyéki tumorszerű
elváltozások között az actinomycosis lehetőségét is szem előtt kell tartani a
differenciáldiagnosztikában. Orv Hetil. 2022; 163(4): 157–160.

Summary. Tumours and other diseases of the urachus are rare. A
67-year-old male presented with a history of recurrent urinary tract infection
and ciprofloxacin therapy. Cystoscopy suggested secondary involvement of the
bullous upper bladder wall. The subsequent CT-based diagnosis was of a tumour
infiltrating the lower median abdominal wall, the urinary bladder and bowels.
Bowel obstruction developed and this led to partial resection of the involved
organs along with a Hartmann’s procedure. Histology revealed no neoplastic
conditions, but proved abdominal actinomycosis of probable urachal origin based
on the location of the tumour-like lesion and umbilical discharge among the
symptoms. Urachal remnants were not identified in the perivesical tissues
involved by the microabscess forming inflammation. Amoxicillin therapy was
initiated. After a temporary urine leakage from the bladder, the patient became
symptomless and was emitted from hospital. After 13 days, he was readmitted
because of abdominal wound disruption, which was treated with negative-pressure
wound therapy before the abdomen could be closed. At the time of reporting, he
is still on amoxicillin, and has become symptomless again. Actinomycosis should
be considered in the differential diagnosis of mass lesions of the urachal
region. Orv Hetil. 2022; 163(4): 157–160.
Mesterséges bőrszövetek a kutatásban és a gyógyításban
Authors: Guba Melinda , Szűcs Diána , Kemény Lajos , Veréb Zoltán
Published: November 2022

Összefoglaló. A bőrpótlóknak mind a klinikumban, mind a
gyógyszerkutatásokban kiemelt szerepük van. Ezek a kezdetleges mesterséges
bőrszövetek segíthetik a bőr regenerálódását, modellezhetik a főbb funkciókat,
de megvannak a korlátaik is, mechanikailag sérülékenyek, és nem tartósak. A
legtöbb bőrpótló vagy acelluláris, vagy csak egy-két sejttípust tartalmaz. Az
eredeti bőrrel megegyező szerkezetű, teljesen funkcionális mesterséges bőrszövet
a mai napig nem létezik. A háromdimenziós szövetnyomtatás megoldást kínálhat
erre a problémára is, hiszen a bőrszövet minden sejtes eleme felhasználható,
megfelelő hidrogélek és biotinták segítségével pedig olyan komplex struktúrák
hozhatók létre, amelyek képesek a bőr teljes funkcionális repertoárját
biztosítani. Ez nemcsak klinikai szempontból kiemelt jelentőségű, hanem a
preklinikai kísérletek esetében kiválthatja az állatmodelleket és számos
toxikológiai vizsgálatot is. Orv Hetil. 2022; 163(10): 375–385.

Summary. Skin substitutes have a prominent role in therapeutic
applications and drug research. These simple artificial skin tissues can support
skin regeneration, in vitro they can model the main functions
of the skin but they also have limitations such as being mechanically vulnerable
and not durable enough. Most skin substitutes are either acellular or contain
only one or two cell types. Fully functional artificial skin substitute with the
same structure as the original skin has not been produced to this day.
Three-dimensional tissue bioprinting can also offer a solution to this problem,
as all cellular elements of skin tissue can be used, and with the help of
appropriate hydrogels and bioinks, complex structures can be created that can
provide a complete functional repertoire of the skin. It is important not just
in the clinical therapeutic use, but it can also trigger the replacement of
animal models and a number of toxicological studies in preclinical trials. Orv
Hetil. 2022; 163(10): 375–385.
De novo 3p25-deletiós szindróma genotípus-fenotípus vizsgálata
Authors: Sarkadi Edina , P. Tardy Erika , Pikó Henriett , Tidrenczel Zsolt , Böjtös Ildikó , Kósa János , Simon Judit
Published: November 2022

Összefoglaló. A 3p25-deletiós szindróma nagyon ritka genetikai
rendellenesség, a nemzetközi szakirodalom jelenleg kevesebb mint 60 esetet ír
le. A kórképre általánosan jellemző a növekedési és pszichomotoros
visszamaradottság, a microcephalia, a hypotonia, a veleszületett szívfejlődési
rendellenesség, a ptosis és micrognathia, de nagyon ritkán előfordul klinikai
tünetek nélküli megjelenése is. Általában újonnan kialakult rendellenesség, bár
egyes esetekben előfordulhat familiáris formája. A kromoszomális töréspont
változó helyen fordul elő. Közleményünkben egy 3p25-deletiós szindrómával
született gyermek esetét mutatjuk be: a deletiót kariotipizálással és
fluoreszcens in situ hibridizációval igazoltuk, majd
microarray-komparatív genomhibridizálással meghatároztuk a pontos töréspontot és
a hiányzó géneket. Az érintett régióban 43 OMIM-gént találtunk, melyek szerepet
játszanak a megkésett pszichomotoros és növekedési elmaradásban, valamint az
intellektuális zavarban. A genetikai háttér pontos karakterizálása hozzásegít a
várható tünetek és a prognózis meghatározásához, egyben támpontot biztosíthat a
jövőbeli terápia tervezéséhez és a személyre szabott fejlesztés kivitelezéséhez.
Orv Hetil. 2022; 163(12): 478–483.

Summary. The 3p25 deletion syndrome is a very rare genetic
abnormality, characterized by growth and psychomotor retardation, microcephaly,
hypotonia, congenital heart defects, ptosis and micrognathia. Less than 60 cases
have been published in the literature so far. However, a few patients with
normal or mild phenotype have also been described. The majority of the cases are
de novo mutations, with variable chromosomal breakpoints.
We present the case of a newborn infant with 3p25 deletion syndrome, whose
genetic analysis was done by karyotyping, fluorescent in situ
hybridization and array comparative genomic hybridization. The latter method
enabled us to define the precise breakpoint and the genes involved in the
deletion, thus we could provide information for further clinical management. We
identified 43 OMIM genes in the deleted region, which may have a causative
effect on the pscychomotor and developmental delay and also on the intellectual
disability. Exact cytogenomic characterisation of a rare genetic syndrome may
allow to employ personalised treatment. Orv Hetil. 2022; 163(12): 478–483.
Vérlemezkében gazdag fibrinnel kezelt parodontalis csontdefektusok gyógyulásának értékelése
Authors: Csifó-Nagy Boróka Klára , Paár Claudia , Dőri Ferenc
Published: November 2022

Összefoglaló. Az autológ vérlemezke-koncentrátumok az orvoslás egyre
több területén kerülnek alkalmazásra. A vérlemezkében gazdag fibrin, ebben a
kategóriában, az adott terápiás lehetőségek közül a legaktuálisabb. Előnyei,
hogy alvadásgátló hozzáadása nélkül preparálható, egy centrifugálást igényel, és
több formában alkalmazható. A vérlemezkében gazdag fibrin újabb generációja
további lehetőségeket teremthet, így a parodontalis sebgyógyulás terén is. Az
esetek bemutatásának célja parodontalis intraossealis csontdefektusok
gyógyulásának rövid távú klinikai értékelése autológ vérlemezkében gazdag
készítménnyel (advanced platelet-rich fibrin) történt kezelést követően. A
bemutatott eseteknél preoperatíven, majd 6 hónappal a műtétet követően történt
kiértékelés a következő parodontológiai paraméterek rögzítésével:
tasakszondázási mélység (probing depth), illetve klinikai tapadási szint
(clinical attachment level). Teljes vastagságú lebenyek képzését követően a
csontdefektus kürettálása, illetve gyökérsimítás történt, majd a preoperatíven
preparált, vérlemezkében gazdag fibrin applikálására került sor, melyet sebzárás
követett. Fél évvel a sebészi beavatkozás után a szondázási mélység csökkenése
és a klinikai tapadási nívó növekedése volt tapasztalható. Bemutatott
eseteinknél a vérlemezkében gazdag fibrin applikációja pozitív klinikai
eredményeket mutatott a parodontalis sebgyógyulás tekintetében. A vérlemezkében
gazdag fibrinnek mint humán autológ preparátumnak a használata elősegítheti a
parodontalis defektusok sikeres kezelését. Orv Hetil. 2022; 163(12):
484–490.

Summary. Autologous platelet concentrates are being used in more and
more areas of medicine. Application of platelet-rich fibrin is the most topical
among these therapeutic options. As main advantages, it can be prepared without
the addition of anticoagulants, requires only one centrifugation and can be used
in various forms. A new generation of platelet-rich fibrin may open up further
opportunities, including those in periodontal wound healing. The aim of this
case series is to provide a short-term clinical evaluation of the healing of
periodontal intrabony defects after treatment with an autologous platelet-rich
fibrin product (advanced platelet-rich fibrin). The presented cases were
evaluated preoperatively and 6 months after surgery by recording the following
periodontal parameters: probing depth and clinical attachment level. After
full-thickness flap preparation, intrabony defect curettage, scaling and root
planing were performed, followed by the application of preoperatively prepared
platelet-rich fibrin and wound closure. Six months after surgery, pocket depth
reductions and clinical attachment level gains were observed. In our presented
cases, the platelet-rich fibrin application showed positive clinical results
regarding periodontal wound healing and may facilitate the successful treatment
of periodontal defects. Orv Hetil. 2022; 163(12): 484–490.
Asthma bronchialéban szenvedő gyermekek közösségimédia-használata
Authors: Józsa Tamás , Túry Ferenc
Published: November 2022

Összefoglaló.
Bevezetés: Az asthma bronchialéban szenvedő fiatalok
egészségmagatartására lényeges hatást gyakorol a virtuális világ (például a
Facebook). Ezt gyakran kötődési hiányállapotaik kompenzálására használják.
Célkitűzés: Az asthmás gyermekek
közösségimédia-használatának vizsgálata egészséges kontrollcsoporttal
összehasonlítva. Módszer: A vizsgálatban 250 fő, 10–18 éves
asthmás, valamint 250 fő, 10–18 éves egészséges gyermek vett részt. Velük a
Facebook Használati Kérdőív, a Ten Item Personality Inventory, a Rosenberg
Önértékelési Skála, a Beck Gyermekdepresszió Kérdőív, valamint a Gyermek
Multidimenzionális Szorongás Skála került felvételre.
Eredmények: Az asthmás gyermekek kevesebb aktív időt
töltenek a Facebookkal, mint az egészségesek (p<0,001), mégis ők érzik azt,
hogy ez a platform inkább az életük része (p<0,001). Az asthmásokat magasabb
depressziószint és szorongás, valamint alacsonyabb önértékelés jellemzi
(p<0,001). Mindkét csoport esetében a lányok használják gyakrabban a
Facebookot. A lányok között a Facebook fokozott használata együtt jár a magasabb
depressziószinttel és szorongással. Következtetés: Az asthmás
gyermekek életében a közösségi média igen jelentős szerepet tölt be. Mivel a
10–18 éves korosztály vulnerábilis ennek addiktív hatásaira, a pszichoedukáció
és a prevenció alapvető volna. Orv Hetil. 2022; 163(15): 593–598.

Summary.
Introduction: The health behavior of patients with asthma
bronchiale can be influenced by the virtual world (e.g.,
Facebook). It is often used to compensate their attachment deficits.
Objective: In this study, the use of social media is
analyzed among asthmatic children compared to a healthy control group.
Method: 250 asthmatic and 250 healthy children were
interviewed from the age of 10 to 18. The Facebook Intensity Scale, the Ten Item
Personality Inventory, the Rosenberg Self-Esteem Scale, the short version of the
Beck Depression Inventory and the Multidimensional Anxiety Scale for Children
were used in the study. Results: Asthmatic children’s social
media time was significantly lower compared to that of healthy children
(p<0.001). However, their feeling of being part of the Facebook community is
the main motivation to use it (p<0.001). Higher scores of anxiety and
depression, and the lower self-esteem compared to the healthy control group can
be detected among asthmatic children (p<0.001). The increased use of Facebook
can be shown in both groups of girls. The increased use of Facebook among girls
is in connection with a higher score of depression and anxiety (p<0.05).
Conclusion: Social media plays a very important role in the
life of asthmatic children. The psychoeducation and prevention is of basic
importance, because the age group of 10–18-year-old children is vulnerable to
the addictive effect of social media. Orv Hetil. 2022; 163(15): 593–598.
Nervus pudendus idegblokád alkalmazása krónikus kismedencei fájdalmat okozó pudendusneuralgia kezelésében
Authors: Romics Miklós , Oláh Orsolya , Perczel Kristóf , Kovács Barbara Petra , Milanovich Dániel , Pintér Éva , Ónody Péter , Majoros Attila
Published: November 2022

A pudendusneuralgia ritka és – objektív tünetek, radiológiai, illetve
laboratóriumi eltérések híján – gyakran nehezen beazonosítható kórkép, melynek
terápiás megoldása komoly kihívás elé állítja a kezelőorvost. Kazuisztikánk egy
krónikus pudendalis fájdalomban szenvedő nőbeteg esetét mutatja be, a
diagnosztikától a kezelésig. Munkánk emellett felhívja a figyelmet arra, hogy a
krónikus, sokszor ismeretlen eredetű és mechanizmusú fájdalmak kivizsgálása és
kezelése az ilyen problémákra specializálódott munkacsoportok – mint a
Semmelweis Egyetem Kismedencei Fájdalom Munkacsoportja – gondozásában nagyobb
eséllyel járhat eredménnyel. Orv Hetil. 2022; 163(24): 967–970.
Ajak- és szájpadhasadékkal társult genetikai szindrómás gyermekek komplex ellátása
Authors: Vástyán Attila , Maros Teodor Barna , Sándor-Bajusz Kinga Amália , Vajda Katalin , Hadzsiev Kinga
Published: November 2022

Bevezetés:Az ajak- és/vagy szájpadhasadékok döntő többségben izoláltan előforduló fejlődési rendellenességek. Kis hányadukban ugyanakkor genetikai szindrómák részei is lehetnek.Célkitűzés:Célunk volt annak vizsgálata, hogy az ajak- és/vagy szájpadhasadék komplex kezelése mennyiben tér el genetikai szindrómát mutató és nem mutató gyermekekben.Módszer:A Pécsi Hasadék Munkacsoport által 1999 és 2015 között kezelt és gondozott gyermekek dokumentációját tekintettük át retrospektív módon. A vizsgálati módszer kiegészült genetikai és epidemiológiai adatokkal.Eredmények:A vizsgált periódusban 607 gyermek került gondozásba. Huszonöt esetben (4,11%) társult az ajak- és/vagy szájpadhasadék egyéb fejlődési rendellenességekkel. Mindösszesen 16 (2,63%) gyermek került az egyértelműen bizonyítható szindrómás csoportba. Az így létrejött mintában 8 különböző szindróma jelent meg, a Robin-szekvencia alkotta az összes eset 50%-át. Tizenhárom szindrómás gyermek esetében tért el a kezelési algoritmus a megszokottól. Az eltérések oka – egy kivételével – visszavezethető volt a genetikai betegségre.Következtetés:Az ajak- és/vagy szájpadhasadékos szindrómás gyermekek kezelése jelentősen eltért a szokásos kezelési algoritmustól. A szindrómához tartozó egyéb rendellenességek (műtéti) kezelése előnyt élvezett az ajak- és/vagy szájpadhasadék rekonstrukciója előtt. Orv Hetil. 2022; 163(21): 826–831.
An empirical evaluation of feature extraction for Vietnamese fruit classification
Authors: Nguyen Trong Thuan , Le Truong Ngoc Hai , Nguyen Nhat Truong , Le Viet Thinh , Duong Thanh Bao Khanh , Tran Thi My Quyen , Bui Long Vu , Nguyen Van Hop , Vo Duy Nguyen , Nguyen Tan Tran Minh Khang
Published: November 2022

In recent years, Vietnamese fruit production has marked significant progress in terms of scale and product structure. Viet Nam enjoys suitable climates for tropic, subtropical fruits, and some temperate fruits. Thanks to the diversified ecology, implementing an automatic classification system has received a significant concern. In this paper, we address the problem of Vietnamese fruit classification. However, the first requirement to explore this problem is the qualified dataset. To this end, we first introduced the UIT-VinaFruit20 dataset, a novel Vietnamese fruit image dataset that includes 63,541 images from 20 types of fruits from three regions of Viet Nam. The diversity in different fruits in distinct areas poses many new challenges. In addition, we further leverage the feature extraction from hand-crafted and deep learning features along with the SVM classification model to effectively classify Vietnamese fruits. The extensive experiments conducted on the UIT-VinaFruit20dataset provide a comprehensive evaluation and insightful analysis. An encouraging empirical success was obtained as the EfficientNetB0 feature achieved the best results of 85.465 % and 86.919 % in terms of Accuracy and Macro F1-score, respectively
Evaluation of anti-inflammatory compounds isolated from Millettia dielsiana Harms ex Diels by molecular docking method
Authors: Nguyen Xuan Ha , Vu Thi Thu Le , Do Tien Lam , Pham Minh Quan , Vu Thanh Dat
Published: November 2022

In this study, we focused on screening and simulating the interaction between anti-inflammatory proteins and 50 compounds isolated from Millettia dielsiana Harms ex Diels. 39 out of 50 compounds that violated no of Lipinski’s rule of five were sorted out as favorable for drug development and selected for studies further. Then, a molecular docking study of compounds into the binding sites of COX-1 and COX-2 allowed shedding light on the binding mode of these potential COX inhibitors performed using Autodock Vina software. Our results showed that 6 compounds, including millesianin E (D32), barbigerone (D18), millesianin D (D31), (+)-epicatechin (D11), durallone (D17), and ichthynone (D19) exhibited good binding energy with the cyclooxygenase-2 (COX-2) enzyme meanwhile all of the selected compounds exhibited poor binding energy to the cyclooxygenase-1 (COX-1) enzyme. The binding energies of these compounds range from -8.6 kcal/mol to -9.0 kcal/mol better than the standard compounds Valdecoxib and Lumiracoxib. In addition, an analysis of the COX-2 enzyme and selected compounds binding was also presented. The important binding modes shown at the active site of the COX-2 enzyme through hydrogen bonds compared with standard compounds showed this as potential candidates against this enzyme. Therefore, these results might give a positive signal in finding anti-inflammatory drugs from Millettia dielsiana.
Preparation and properties of rubber nanocomposites based on natural rubber/ ethylene propylene diene monomer reinforced with nanosilica, carbon black and barium sulfate
Authors: Do Quang Khang , Tran Huu Quang , Trung Sy Do , Tien Dung Nguyen , Huu Huy Tran , Thi Diep Nguyen , Quynh Trang Pham , Cong Nguyen Pham
Published: November 2022

In this work, rubber nanocomposites based on natural rubber/ethylene propylene diene monomer (NR/EPDM) blends and reinforced with nanosilica (NS) in combination with carbon black (CB) and barium sulfate (BS) were prepared by melt blending method in a Brabender internal mixer. The appropriate contents of NS and CB for reinforcing the rubber nanocomposites based on NR/EPDM are 10 and 30 phr (parts per hundred rubber), respectively. The NR/EPDM nanocomposites material reinforced with 10 phr NS and 30 phr CB has the best mechanical properties that with the enhancement of tensile strength over 117% and 40 % compared to that of the NR/EPDM nanocomposite material unreinforced and reinforced with only 10 phr NS, respectively. The appropriate content of BS for replacement of CB in the NR/EPDM blend is 6 phr. The rubber nanocomposite based on NR/EPDM (60/40) blend reinforced with 10 phr NS, 24 phr CB and 6 phr BS has a tight structure, high mechanical properties, and especially, high alkali resistance and heat resistance, abrasion resistance and low endogenous heat due to rotation and friction. This material may be used to manufacture technical rubber products that require heat resistance and stability in alkaline environments, such as conveyor belts used in the cement industry.
Effect of zirconia nanoparticles modified by silane coupling agent on some properties of epoxy coating
Authors: Dao Phi Hung , Nguyen Thuy Chinh , Nguyen Anh Hiep , Nguyen Xuan Thai , Ly Thi Ngoc Lien , Hoang Thi Huong Giang , Dao Huu Toan , Thai Hoang
Published: November 2022

Effect of zirconia nanoparticles (zirconia NPs/ZrO2 NPs) modified by 3 wt.% (glycidyloxypropyl) triethoxysilane – GPTES (m-ZrO2 NPs) on some properties of epoxy coating such as mechanical properties, thermal stability and anti-corrosion performance was investigated. The obtained results indicated that the addition of zirconia nanoparticles to epoxy coating could enhance the properties of this coating. The addition of 2 wt.% of pure ZrO2 NPs (u-ZrO2 NPs) to the epoxy matrix could increase the mechanical properties (hardness and adhesion to the steel substrate) by approximately 10 %, the onset temperature of thermal degradation of the epoxy/u-ZrO2 NPs coating was 4.4 oC higher, and the anti-corrosion performance of epoxy coating was improved in comparison with the neat epoxy coating. Organically modified ZrO2 NPs had higher improvement for epoxy coating’s properties than pure ZrO2 NPs. The epoxy coating filled with m-ZrO2 NPs had 19.7 % higher in relative hardness, 88.73 % more in adhesion to steel substrate, 25.6 oC higher in the onset temperature of thermal degradation, and higher anti-corrosion performance in comparison with the epoxy coating filled with 2 wt.% of pure zirconia nanoparticles. The cross-section FESEM images of the epoxy/m-ZrO2 NPs coating showed that m-ZrO2 NPs could regularly disperse in epoxy polymer matrix while unmodified zirconia nanoparticles (u-ZrO2 NPs) were agglomerated to big cluster in the epoxy coating. This was the reason for the high performance of the epoxy coating filled with zirconia NPs modified by GPTES.
Actor-Network Structure of Collective Historical Memory
Authors:   Sevastopol State University, Yarmak Olga , Bolshakova Mariya ,   Sevastopol State University, Savina Zoya ,   Sevastopol State University, Maranchak Anastasia ,   Sevastopol State University
Published: November 2022

The authors carried out an analysis of semantic constructions about the role of Sevastopol in the Great Patriotic War. The basic question of the study is to assess the risks and opportunities of countering the technologies of information and cognitive wars, the scenarios of which involve the formation of lines of "civilizational faults" that destabilize social processes with the reformatting of history. The relevance of this research is connected with the definition of mechanisms for creating new historical and media meanings in the conditions of hybrid confrontation and modeling different variants of the development of historical events with changes in the historical and political maps of the world. First of all, this process concerns assessments of the Great Patriotic War and Victory as a historical and geopolitical achievement of Russia. The scientific novelty of the study consists in considering the collective memory of the Great Patriotic War as a network in the understanding of actor-network theory. It was revealed that the historical collective memory is filled with new symbols and signs, turning into an unstructured stream. Social actions that determine historical attitudes are being reinterpreted, a new symbolism becoming a new sociality with the broadcast of "victory" and the rejection of social and geopolitical achievements in the Great Patriotic War of the Russian people and the Soviet state. The current state of historical collective memory is filled with traces formed by both a fundamental event – the Victory in the Great Patriotic War, and events of a political and social nature. Consideration of the collective memory of the Great Patriotic War as a network in the understanding of the actor-network theory allowed us to identify signs of information campaigns aimed at discrediting the role of the Soviet Union and transforming the Victory Day through the formation of an "import" information agenda.
Una Propuesta de Corrección en Tasas De Mortalidad por Diabetes Mellitus para Ciudades Colombianas con Problemas de Subregistros, 2005 – 2017
Authors: Sandoval Juan de Jesus , Contreras B. Piedad Urdinola , Sarmiento Paula A. Rivera
Published: November 2022

El recuento de la mortalidad por enfermedades de baja prevalencia como la Diabetes Mellitus (DM), sufre de problemas serios de subregistro debido a la ausencia de datos, representados en ceros en el sistema de estadísticas vitales, lo que dificulta la necesidad de identificación de los patrones sobre todo de enfermedades que son silenciosas.

Esta investigación propone una corrección a las tasas de mortalidad para poblaciones pequeñas con alta inflación en ceros, como es el caso de la serie anual de Diabetes Mellitus (DM) para ciudades colombianas en edades de 20 a 80 años, entre los años 2005 y 2017. Se propone una modificación al modelo bayesiano jerárquico propuesto por Alexander et al. (2017), reemplazando la distribución original por una Binomial Negativa y utilizando los patrones de defunciones por la misma causa de otros países en la región, en años recientes. Con éste, se corrigieron las tasas de mortalidad por esta causa, edad, sexo y ciudad. Los resultados mostraron una apropiada corrección para las edades que oficialmente reportan ceros, manteniendo la brecha natural entre sexos, y una corrección mayor para las ciudades más pequeñas, frente a las grandes ciudades, cuando se comparó con otros modelos.

Con esta metodología se permitirá ayudar a la vigilancia epidemiológica de las enfermedades de baja prevalencia como la hipertensión, enfermedades coronarias y similares, con altos niveles de subregistro; pero que requieren de mediciones precisas a nivel subnacional para la toma de decisiones de salud pública. Cifras equivocadas solo llevarían a toma de decisiones erróneas, por ello es de vital importancia generar este tipo de correcciones.
Microbiota-Specific Foxp3+ Regulatory T Cells Could Control Pathological T Helper Responses
Authors: Usharauli David , Kamala Tirumalai
Published: November 2022

Upon engaging cognate peptide MHC-II complexes (pMHC-IIs), naive CD4+ T cells differentiate and acquire several T helper (Th) fates, guided by a dynamic cytokine milieu following antigenic challenge. This physiological Th fate choice process is often erroneously conflated with a maladaptive pathological process historically termed Th polarization. Here we propose why these two processes are distinct and separable. We posit that, though innate signaling alone is sufficient for Th fate choice in naive CD4+ T cells, Th polarization instead strictly originates from pre-existing cross-reactive memory CD4+ T cells. We further posit that Th polarization is normally prevented by thymus-derived cross-reactive antigen-specific regulatory T cells (Tregs) and inevitably manifests as immunopathology when the Treg repertoire and the microbiota that maintains it are selectively depleted. Bifurcating Th fate choice and polarization delineate Th effector pathways more accurately and tangibly improve the scope of targeted therapies for allergies, autoimmune diseases, and effective vaccines.
EXTRACTION AND CHARACTERIZATION OF BIODIESEL DERIVED FROM THE COFFEE HUSK AND ITS EFFECT ON DIESEL ENGINE PERFORMANCE AND EMISSION CHARACTERISTICS
Authors: Emma Addisu Frinjo , Sathyabhama Alangar , Yadav Ajay Kumar
Published: November 2022

This study investigates the suitability of coffee husk (CH) and spent coffee ground (SCG) as the biomass energy source to produce biodiesel. The chemical composition was determined using the field emission gun scanning electron microscope (FEG-SEM). The carbon and oxygen concentration in CH was 49.84% and 48.06%, respectively, by weight. The SCG had 67.72% of carbon and 26.18% of oxygen by weight. The oil extracted from CH was converted into biodiesel using the transesterification process. The properties of the biodiesel, such as flashpoint, fire point, viscosity, calorific value, and density, were measured. The engine's performance and emission characteristics were investigated by blending the produced biodiesel with regular diesel. It was found that by using CHOME biodiesel-diesel blends, exhaust gas emissions such as HC, CO, and smoke opacity were considerably reduced, while CO2 and NOx emissions increased. The brake thermal efficiency (BTE) of the engine was slightly reduced, and brake specific energy consumption (BSFC) was increased.
Maitake Medicinal Mushroom, Grifola frondosa (Agaricomycetes), and Its Neurotrophic Properties: A Mini-Review
Authors: Naguib Adrina Mohamad , Apparoo Yasaaswini , Xiong Chuan , Phan Chia Wei
Published: November 2022

Neurodegeneration is one of the most common manifestations in an aging population. The occurrence of oxidative stress and neuroinflammation are the main contributors to the phenomenon. Neurologic conditions such as Alzheimer's disease (AD) and Parkinson's disease (PD) are challenging to treat due to their irreversible manner as well as the lack of effective treatment. Grifola frondosa (Dicks.: Fr.) S.F. Gray, or maitake mushroom, is believed to be a potential choice as a therapeutic agent for neurodegenerative diseases. G. frondosa is known to be a functional food that has a wide variety of medicinal purposes. Thus, this review emphasizes the neuroprotective effects and the chemical composition of G. frondosa. Various studies have described that G. frondosa can protect and proliferate neuronal cells through neurogenesis, antioxidative, anti-inflammatory, and anti-β-amyloid activities. The mechanism of action behind these therapeutic findings in various in vitro and in vivo models has also been intensively studied. In this mini review, we also summarized the chemical composition of G. frondosa to provide a better understanding of the presence of nutritional compounds in G. frondosa.
A TIME-MIRRORING (TM) SCHEME FOR ICI MITIGATION IN TIME-VARYING CHANNEL FOR DIGITAL VIDEO BROADCASTING (DVB) SYSTEMS
Authors: Elbakry Mohamed S. , Ramadan Khaled
Published: November 2022

High mobility and high data speeds are now highly important requirements. The orthogonal frequency division multiplexing (OFDM) structure, which suffers from inter-carrier interference (ICI) in time-varying channels, is the basic core method in digital video broadcasting (DVB). Hence, the bit error rate (BER) is declined. In this paper, the time mirroring (TM) based on the symbol time compression (STC) technique for entire ICI suppression for DVB systems is proposed. In addition, some missing analysis for STC technique and ICI power analysis is introduced. Finally, the computational complexity of the proposed TM scheme is determined. The simulation results show that the proposed scheme reduces the ICI power by a significant amount when compared to the other traditional schemes. In comparison to traditional systems, the BER performance is greatly enhanced, and the eye diagram is entirely opened. In addition, as compared to traditional schemes, the proposed approach can handle normalized Doppler frequency by up to 40% and it has about the same computational complexity as the STC scheme but it is more efficient in terms of computational complexity than the traditional OFDM system.
With the Best of Intentions: Venice Art Biennale 2022
Authors: Harvey Neil Morris
Published: November 2022

A circumspect and mildly critical review of this year's Venice Art Biennale. It considers the question of what aspect of such a major art event are the most salient as regards critical response.
House Price Growth and Inflation During COVID-19
Authors: Aladangady Aditya , Anenberg Elliot , Garcia Daniel
Published: November 2022

House prices have risen rapidly during the pandemic, creating $9 trillion in owner occupied housing wealth between the first quarter of 2020 and the first quarter of 2022. Both housing and non-housing inflation also moved up over this time period to its highest level in many decades.
Intellectual property safe – First-to-File and First-to-Invent system
Authors: Cecilia Young
Published: November 2022

All countries use the First-to-File system. An inventor may feel very tense about the time race and the physical and cyber security of his intellectual properties. Biomedical researchers and inventors are particularly vulnerable since most of them may not possess enough IT knowledge to maintain cyber security. An Intellectual Property Safe System to protect the initial draft and/or prototypes is suggested.
A look at intercultural sensitivity from the perspective of mindfulness and acceptance of diversity
Authors: UYGUR Sevgi
Published: November 2022

Although the concept of mindfulness is gradually increasing its use in the intercultural literature, it is seen that there has not been enough empirical research on the role of mindfulness in intercultural relations and the variables related to intercultural relations. One of the intercultural variables is intercultural sensitivity. In today's world, which is getting richer with increasing diversity, it can be said that approaching intercultural sensitivity from the framework of mindfulness will provide a more comprehensive understanding. Acceptance of diversity is one of the variables that are emphasized in the culturally sensitive approach processes. Therefore, it is thought that mindfulness and acceptance-based approaches will positively affect intercultural sensitivity. In this study, it was aimed to reveal the roles of mindfulness and acceptance of diversity variables in predicting the intercultural sensitivity levels of university students. The study is a descriptive research in which the correlational survey model was used and the data were collected with the convenience sampling method. 336 university students participated voluntarily in the study. Acceptance of Diversity Scale (ADS), Adolescent and Adult Mindfulness Scale (AAMS), Intercultural Sensitivity Scale (ISS), participant information form were used as data collection tools. Multiple Linear Regression Analysis and Pearson Product Moment Correlation techniques were used in the analyses. The findings revealed that the sub-dimensions of Adolescent and Adult Mindfulness Scale -focus on the present moment, being non-reactive, non-judgmental, self-accepting- and acceptance of diversity explained 33% of intercultural sensitivity level. As a result, it is a necessity to provide an inclusive and supportive environment free from discrimination for every individual of society and to protect their well-being. In order to foster intercultural sensitivity; it is of great importance to promote mindfulness and acceptance of diversity.
Physical and chemical analysis of watered engine oil
Authors: Kolunin Alexander V.
Published: November 2022

BACKGROUND: The condition of engine chemistroils работыdefines reliability of piston engines operation additivessubstantially. However, colloid-chemical transformation, influenced by various factors, including oil watering, takes place in oils during storage and application. There is variety of ways how water may inflow in engine oils.
AIMS: The aim of the study is to reveal consequences of oil watering and negative influence of water on operational properties of engine oils.
METHODS: Watering of production engine oils was carried out in laboratory conditions. Mixes hazievof engine oils with water were prepared in various proportions. Influence of water on the condition of engine ёмкостoils уровнемwas estimated by visual observation, as well asокисления with application of the methods according to GOSTя and ASTM standards. The laboratory equipment, produced in Russia and the USA, provides comprehensible depth of scientific knowledge of physical and chemical processes.
RESULTS: The assessment of water influence on the engine oil condition was carried out on the basis of observation and the analysis of charactieristic curves. Change of concentration of additives, dissolved at the oil base, was estimated with change of base number and indicator elements.
CONCLUSIONS: The practical significance of this study involves integrity of the approach to the issueизменению of the engine oil condition change, influenced by water, regarding the concentration of the dissolved additives. Unjustifiably active processes of corrosion and wear of details surfaces are possible consequences of oil watering. Crankshaft bearings coating has the highest vulnerability to the influence of acids. The mentioned consequences have a negative impact on service life and reliability of piston engines operation.
Optimization of the main parameters of the diesel engine during its operation on the multicomponent biofuel composition
Authors: Plotnikov Sergey A. , Kartashevich Anatoliy N. , Simonov Maksim V. , Shipin Alexandr I.
Published: November 2022

BACKGROUND: When conducting experimental studies aimed at finding optimal parameters of the diesel engine operating mode, as well as other objects, the issue of reducing the volume of the experiment becomes acute. The use of modern methods of planning, obtaining, processing and analyzing experimental data allows to reduce significantly the number of experiments conducted without notable loss of the reliability of the data obtained.
AIMS: The aim of this study is to determine the optimal operating characteristics of the diesel engine, which uses the multi-component bio-fuel composition.
METHODS: In order to determine the optimal values of the main parameters, affecting the effective indicators of the 4ChN 11.0/12.5 diesel engine when operating on the multicomponent biofuel composition and a mathematical description of their relationship, a second-order three-factor Box Benken plan was implemented. These factors are effective load, crankshaft rotational speed, and fuel injection advance angle. The diesel engine operation studies were performed on the most stable mixture of the multicomponent biofuel composition, including the following ingredients, wt %: rapeseed oil 34.5; ethanol 31.0; diesel fuel 34.5. The search of a compromise solution for the optimal combination of the levels of studied factors was performed with the method of superimposing of bidimensional sections of the response surfaces of the effective efficiency factor and the specific effective fuel consumption.
RESULTS: Adequate models of second-order regression analysis of changes in effective efficiency factor and specific effective fuel consumption have been obtained. The factor space is described and grapho-analytical studies are carried out. The analysis of regression models and bidimensional sections of response surfaces allowed to determine the optimal values of the studied factors. The method for determining the optimal load and speed ranges of the diesel engine operation, using the multicomponent biofuel composition, has been optimized due to the application of the experimental plan and the description of the factor space by mathematical models, while number of experiments was reduced.
CONCLUSIONS: The optimal area of the combination of the factors is in the range of varying the rotational speed of the diesel engine crankshaft n=1400...1550 rpm and the effective load Pe=0.68...0.85 MPa at the fuel injection advance angle Ѳinj=23.5 degrees to TDC. Considering the variable nature of the load and speed modes of a diesel engine in a real operation environment, the obtained data are of practical interest.
The creators of tracked agricultural tractors. Dedicated to the 90th anniversary of the first domestic tractor engineering bureau
Authors: Kosenko Vyacheslav V.
Published: November 2022

90 years ago, in 1932, Design and Experimental Department (DED STP) was established at Stalingrad Tractor Plant the first specialized design department of tractor engineering in our country. During the time of existence of this department, the factory chief design engineers were V.G. Stankevich (19321938), M.M. Romanov (19381940), V.A. Kargopolov (19431949), A.K. Platonov (19491950), A.Ya. Merilov (19511957), M.A. Sharov (19581980), V.P. Shevchuk (19801996), V.Ya. Bokov (19961998), I.A. Dolgov (19982005), V.V. Kosenko (20062010). The article contains the review of main achievments, made by the department, led by each of them. Throughout these years 5 families of tracked agricultural tractors were developed at Stalingrad (Volgograd from 1961) Tractor Plant, such as STZ-NATI, DT-54, DT-75, DT-175S and VT-100, with a wide range of special modifications (transport, swamp, hillside, peat, plowing and cultivating, etc) and configurations. Short stories of the creation of these machines, their characterisics and advantages over the predcessors are given. The tractors of STP (VgTP) were used in agriculture as well as in many other areas of our countrys economy, were exported to foreign countries and deserved respect and love from tractor drivers and maintenance specialists. Overall about 4 million tractors were produced according to technical documentation, developed by design engineers of STP (VgTP) or with their direct involvement.
Innovative strategic session in the scientific activity of the Center for Diagnostics and Telemedicine
Authors: Vinogradova Irina A. , Nizovtsova Lyudmila A. , Omelyanskaya Olga V.
Published: November 2022

Sometimes, you need to go beyond the possible and ordinary in order to create something new. Human potential is limitless, and the world of technological possibilities opens up new horizons and helps to achieve the most difficult goals.
A real scientist should think out of the box and go beyond the rules. Sticking with what we know today and being not open to new knowledge hinders our scientific progress. It is quite difficult, if not impossible, to get rid of bias. Similar to how it is almost beyond our possibilities to pull yourself out of the rut of the rules without a help.
However, we tried to do impossible possible at our Science Week. The last week of July at the Research and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Healthcare Department was highlighted by this outstanding extraordinary event. During this week, the importance of scientific discoveries for both an individual and whole society was demonstrated. In fact, it was a platform for discussing advanced technologies, challenges, and solutions. For 4 days, the scientists of the Center presented their reports and defended their ideas. Their colleagues took part in the discussion and asked questions about the application and implementation of their initiatives.
Analysis of the gut microbiome of patients with HIV infection using 16S rRNA-sequencing
Authors: Popova Darya M. , Voznesenskiy Sergey L. , Petrova Elena V. , Klimkova Polina V.
Published: November 2022

BACKGROUND: The microbiota of the gastrointestinal tract is one of the important factors that ensure the normal functioning of the human body. Patients with HIV infection are most susceptible to intestinal infections and changes in the composition of the microbiota, both due to exposure to the virus itself and reduced immunity. This study describes changes in the composition of the intestinal microflora of patients with HIV infection at the stage of secondary diseases, with and without antiretroviral therapy.
AIM: To determine the composition of the gut microbiome in patients with HIV infection on and off antiretroviral therapy using DNA sequencing of the hypervariable regions of the 16S rRNA gene.
MATERIALS AND METHODS: The study analyzed a group of 10 patients with a confirmed diagnosis of HIV infection and diarrheal syndrome. To clarify a possible etiological factor and determine the characteristics of the microbiocenosis of the gastrointestinal tract, stool analysis was performed using the 16S rRNA-sequencing method.
RESULTS: The study revealed significant changes in the composition of the microbiome: depletion of the Bacteroidetes type and increased number of the Proteobacteria type. A statistically significant difference was found in the composition of the types of microbiota in healthy people and patients with HIV infection (p 0.05). The normal flora was represented by only two microorganisms: Bifidobacterium breve and Lactobacillus rhamnosus. Conditionally pathogenic microorganisms were identified, namely, Enterococcus faecium, E. faecalis, Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Enterococcus durans, Klebsiella sp., Pantoea agglomerans, K. variicola, E. hirae, E. coli TOP550-1, Clostridioides difficile, and Staphylococcus aureus. These bacteria may be the cause of diarrheal syndrome in patients with HIV infection.
CONCLUSION: In patients with HIV infection, bacterial diversity is reduced, normal flora is depleted, and a specific microbial profile is formed. Several conditionally pathogenic microorganisms can cause diarrhea in patients with HIV infection. Analysis of 16S rRNA-sequencing can be a non-invasive method for diagnosing changes in the composition of the intestinal microflora and clarifying the etiological factor of diarrheal syndrome.
Earthquake Delay and Rupture Velocity in Near-Field Dynamic Triggering Dictated by Stress-Controlled Nucleation
Authors: Dong Peng , Chen Rong , Xia Kaiwen , Yao Wei , Peng Zhigang , Elsworth Derek
Published: November 2022

Dynamic triggering of earthquakes by seismic waves generated by another earthquake is widely observed, while the underlying nucleation mechanisms remain unclear. We report here dynamically triggered earthquakes on laboratory faults with tightly constrained imaging of the triggering process. The arriving stress wave alters the contact state of the laboratory fault and initiates rupture nucleation in two distinct phases. The triggered rupture grows at a fraction of the shear-wave velocity (∼0.4CS) and then transits to a very slow velocity (∼0.1CS) before culminating into runaway shear. This intervening very slow rupture phase is present only for seismic ratios conducive to sub-Rayleigh ruptures and is notably absent for supershear events. Thus, the delay in triggering decreases to a minimum for triggered supershear ruptures, whereas it scales with the stress state for triggered sub-Rayleigh ruptures. These results may help explain key characteristics of delayed near-field dynamic triggering and provide a simple theoretical framework for dynamic triggering at greater distances.
ANALISIS KARAKTER TOKOH SYATURI DALAM CERPEN RUMOR KARYA CATUR STANIS
Authors: Dewanty Imanuella Anastasia Brigitha Carneliaputri
Published: November 2022

ABSTRAK: Stanis dalam cerpennya, Rumor, menggambarkan Syaturi sebagai gelandangan tetapi karakternya tidak sesuai dengan latar belakangnya. Artikel ini bertujuan untuk menganalisis karakter Syaturi berdasarkan teori pendeskripsian karakter Murphy. Langkah kerja penelitian melingkupi, pengumpulan data, analisis data, dan penyajian hasil analisis. Berdasarkan hasil analisis, karakter Syaturi dideskripsikan melalui pandangan tokoh lain, ucapan tokoh, reaksi, sikap, dan tingkah laku. Karakter Syaturi digambarkan sebagai seorang yang introvert, tahu balas budi, memiliki kemampuan untuk menilai dirinya, bersifat tenang, dan bijaksana.