bluuebunny/crossref_metadata_2025 huggingface dataset:
Solanum lycopersicum, a Model Plant for the Studies in Developmental Biology, Stress Biology and Food Science
Authors: Liu Wei , Liu Kui , Chen Daoguo , Zhang Zhanquan , Li Boqiang , El-Mogy Mohamed M. , Tian Shiping , Chen Tong
Published: August 2022

Fruits, vegetables and other plant-derived foods contribute important ingredients for human diets, and are thus favored by consumers worldwide. Among these horticultural crops, tomato belongs to the Solanaceae family, ranks only secondary to potato (S. tuberosum L.) in yields and is widely cultivated for fresh fruit and processed foods owing to its abundant nutritional constituents (including vitamins, dietary fibers, antioxidants and pigments). Aside from its important economic and nutritional values, tomato is also well received as a model species for the studies on many fundamental biological events, including regulations on flowering, shoot apical meristem maintenance, fruit ripening, as well as responses to abiotic and biotic stresses (such as light, salinity, temperature and various pathogens). Moreover, tomato also provides abundant health-promoting secondary metabolites (flavonoids, phenolics, alkaloids, etc.), making it an excellent source and experimental system for investigating nutrient biosynthesis and availability in food science. Here, we summarize some latest results on these aspects, which may provide some references for further investigations on developmental biology, stress signaling and food science.
Effect of Thermal Treatment on the Physicochemical, Ultrastructural, and Antioxidant Characteristics of Euryale ferox Seeds and Flour
Authors: Li Qin , Li Hong-Tao , Bai Yi-Peng , Zhu Ke-Rui , Huang Ping-Hsiu
Published: August 2022

Euryale ferox seeds (EFS) were less gelatinized, preventing the release of nutrients and functional compounds, resulting in limited applications in meals and the food industry. Nutraceutical importance of EFS includes starch, protein, lipids, 20 amino acids, minerals, and vitamins (C, E, and beta carotene). This study aimed to evaluate the effect of three different thermal treatments on EFS’s physicochemical and nutritional properties and expected to improve its applicability. The results showed that the bulk density, thousand-grain weight, and hardness of thermal treated EFS were significantly decreased (p < 0.05), whereas the maximum decrease was observed in the industrial infrared heating-assisted fluidized bed (IHFH) treatment. Meanwhile, there were more crevices, fissures, and heightened porous structures in EFS between the pericarp and episperm and the endosperm after heat treatment, which facilitated grinding and water absorption. Notably, EFS’s water and oil absorption capacities increased significantly (p < 0.05) with microwave and IHFH treatments. EFS ground’s solubility into powder was increased significantly with thermal treatment (p < 0.05). Furthermore, the functional properties of TPC, TFC, DPPH radical scavenging activity, and reducing power were significantly increased (p < 0.05). In general, the changes in the physicochemical properties of EFS and increased bioactivity were caused by microwave and IHFH treatments. Hence, it might improve the food value of EFS while providing valuable information to researchers and food manufacturers.
Historical Westward Migration Phases of Ovis aries Inferred from the Population Structure and the Phylogeography of Occidental Mediterranean Native Sheep Breeds
Authors: Ben Sassi-Zaidy Yousra , Mohamed-Brahmi Aziza , Chaouch Melek , Maretto Fabio , Cendron Filippo , Charfi-Cheikhrouha Faouzia , Ben Abderrazak Souha , Djemali Mnaour , Cassandro Martino
Published: August 2022

In this study, the genetic relationship and the population structure of western Mediterranean basin native sheep breeds are investigated, analyzing Maghrebian, Central Italian, and Venetian sheep with a highly informative microsatellite markers panel. The phylogeographical analysis, between breeds’ differentiation level (Wright’s fixation index), gene flow, ancestral relatedness measured by molecular coancestry, genetic distances, divergence times estimates and structure analyses, were revealed based on the assessment of 975 genotyped animals. The results unveiled the past introduction and migration history of sheep in the occidental Mediterranean basin since the early Neolithic. Our findings provided a scenario of three westward sheep migration phases fitting properly to the westward Neolithic expansion argued by zooarcheological, historical and human genetic studies.
Therapeutic Use of VR Serious Games in the Treatment of Negative Schizophrenia Symptoms: A Systematic Review
Authors: Miranda Beatriz , Moreira Pedro Miguel , Romero Luís , Rego Paula Alexandra
Published: August 2022

Schizophrenia is a chronic brain disorder that affects 1 in every 300 people worldwide. This study intended to perform a systematic review to describe the state-of-the-art of interventions involving patients with negative symptoms of schizophrenia that use Virtual Reality (VR) games as a complement to therapy, and to analyze the key features of such games. Literature research was conducted in three databases, namely, the Institute of Electrical and Electronics Engineers (IEEE), Scopus, and PubMed, to identify relevant publications dated from 2010 to 2021. Of the initial 74 publications found, only 11 satisfied the eligibility requirements and were included in this study. The results were then organized and displayed in a flow diagram. Overall, the results from the studies suggest that the use of VR in therapies enables an increase in social skills and a decrease in anxiety symptoms. The use of such technology in therapy has proven to be effective, although it still lacks features to provide better long-term results.
Design and Implementation of a Comprehensive AI Dashboard for Real-Time Prediction of Adverse Prognosis of ED Patients
Authors: Tsai Wei-Chun , Liu Chung-Feng , Lin Hung-Jung , Hsu Chien-Chin , Ma Yu-Shan , Chen Chia-Jung , Huang Chien-Cheng , Chen Chia-Chun
Published: August 2022

The emergency department (ED) is at the forefront of medical care, and the medical team needs to make outright judgments and treatment decisions under time constraints. Thus, knowing how to make personalized and precise predictions is a very challenging task. With the advancement of artificial intelligence (AI) technology, Chi Mei Medical Center (CMMC) adopted AI, the Internet of Things (IoT), and interaction technologies to establish diverse prognosis prediction models for eight diseases based on the ED electronic medical records of three branch hospitals. CMMC integrated these predictive models to form a digital AI dashboard, showing the risk status of all ED patients diagnosed with any of these eight diseases. This study first explored the methodology of CMMC’s AI development and proposed a four-tier AI dashboard architecture for ED implementation. The AI dashboard’s ease of use, usefulness, and acceptance was also strongly affirmed by the ED medical staff. The ED AI dashboard is an effective tool in the implementation of real-time risk monitoring of patients in the ED and could improve the quality of care as a part of best practice. Based on the results of this study, it is suggested that healthcare institutions thoughtfully consider tailoring their ED dashboard designs to adapt to their unique workflows and environments.
Network Analysis for a Community-Based School- and Family-Based Obesity Prevention Program
Authors: Brauer Katharina , Wulff Hagen , Pawellek Sabine , Ziegeldorf Alexandra
Published: August 2022

Rising childhood obesity with its detrimental health consequences poses a challenge to the health care system. Community-based, multi-setting interventions with the participatory involvement of relevant stakeholders are emerging as promising. To gain insights into the structural and processual characteristics of stakeholder networks, conducting a network analysis (NA) is advisable. Within the program “Family+—Healthy Living Together in Families and Schools”, a network analysis was conducted in two rural model regions and one urban model region. Relevant stakeholders were identified in 2020–2021 through expert interviews and interviewed by telephone to elicit key variables such as frequency of contact and intensity of collaboration. Throughout the NA, characteristics such as density, centrality, and connectedness were analyzed and are presented graphically. Due to the differences in the number of inhabitants and the rural or urban structure of the model regions, the three networks (network#1, network#2, and network#3) included 20, 14, and 12 stakeholders, respectively. All networks had similar densities (network#1, 48%; network#2, 52%; network#3, 42%), whereas the degree centrality of network#1 (0.57) and network#3 (0.58) was one-third higher compared with network#2 (0.39). All three networks differed in the distribution of stakeholders in terms of field of expertise and structural orientation. On average, stakeholders exchanged information quarterly and were connected on an informal level. Based on the results of the NA, it appears to be useful to initialize a community health facilitator to involve relevant stakeholders from the education, sports, and health systems in projects and to strive for the goal of sustainable health promotion, regardless of the rural or urban structure of the region. Participatory involvement of relevant stakeholders can have a positive influence on the effective dissemination of information and networking with other stakeholders.
Associations between Family Functioning and Symptoms of Attention-Deficit Hyperactivity Disorder (ADHD): A Cross-Sectional Study
Authors: Choksomngam Yanee , Jiraporncharoen Wichuda , Pinyopornpanish Kanokporn , Narkpongphun Assawin , Ongprasert Krongporn , Angkurawaranon Chaisiri
Published: August 2022

Poor family functioning is linked with poor child ADHD symptoms. However, there are many dimensions of family functioning. Thus, this study aims to find the association between each dimension of family functioning and controlled ADHD symptoms in an Asian culture. This cross-sectional study involved caregivers of 113 Thai children with ADHD ages 4–16 years old who visited the Outpatient Department at Maharaj Nakorn Chiang Mai Hospital between October 2017 and March 2018. The caregivers completed the Chulalongkorn Family Inventory and the SNAP-IV Thai version. Logistic regression was used to examine each dimension of family functioning adjusting for potential confounders. In univariate analyses, six of the seven dimensions of family functioning were associated with controlled ADHD symptoms. In multivariate analyses, findings revealed that good family roles (aOR 7.48, 95% CI = 1.56 to 35.85, p = 0.01) and behavior control (aOR 2.56, 95% CI = 1.08 to 6.03, p = 0.03) were associated with controlled ADHD symptoms. In children with ADHD with poor symptom control, the assessment of family functioning could be helpful. Developing a more specific intervention for caregivers that promotes good family roles and behavioral control may be beneficial.
Dysbiosis: A Potential Precursor to the Development of a Depressive Disorder
Authors: Chung Seung-Young , Kostev Karel , Tanislav Christian
Published: August 2022

Background: Although previous investigations have indicated that gastrointestinal pathologies facilitate the occurrence of mood disorders, there is a lack of studies based on data from clinical practice. The aim of this study was to investigate the incidence of depression in patients with dysbiosis. Methods: Adult patients (≥18 years) from 1193 general practices in Germany between January 2005 and December 2018 with an initial diagnosis of dysbiosis documented anonymously in the Disease Analyzer database (IQVIA) were analyzed. The incidence of depression diagnoses as a function of dysbiosis was calculated and multivariate regression models were applied. Results: This study included 552 patients with and 552 patients without dysbiosis. Within five years of the index date, 20.5% of patients with dysbiosis and 5.5% of individuals without dysbiosis had been diagnosed with depression (p < 0.001). Dysbiosis was found to be significantly associated with the incidence of depression (HR: 2.85 (95% CI: 2.00–4.04)). This association was slightly stronger in men (HR: 3.54) than in women (HR: 2.61) and was more pronounced in the age group >60 years (HR: 4.43). Conclusions: We identified dysbiosis as a risk factor for developing depression within 5 years after the index date. This risk seems to be higher in male than in female patients.
Feasibility and Quality Validation of a Mobile Application for Enhancing Adherence to Opioids in Sickle Cell Disease
Authors: Sop Daniel M. , Crouch Taylor , Zhang Yue , Lipato Thokozeni , Wilson John , Smith Wally R.
Published: August 2022

Prescription opioid nonadherence, specifically opioid misuse, has contributed to the opioid epidemic and opioid-related mortality in the US. Popular methods to measure and control opioid adherence have limitations, but mobile health, specifically smartphone applications, offers a potentially useful technology for this purpose. We developed, tested, and validated the OpPill application using the Mobile Applications Rating Scale (MARS), a validated tool for assessing the quality of mobile health apps. The MARS contains four scales (range of each scale = 0–4) that rate Engagement, Functionality, Aesthetics, and Information Quality. It also assesses subjective quality, relevance, and overall application impact. Our application was built to be a mobile monitoring and reporting system intended to enhance opioid adherence by collecting data and providing systematic feedback on pain and opioid use. Patients (n = 28) all had one of various SCD genotypes, were ages 19 to 59 years (mean 36.56), 53.6% were female, and 39.3% had completed some college. Patients rated the OpPill application highly on all four scales: Engagement, 3.93 ± 0.73; Functionality, 4.54 ± 0.66; Aesthetics, 3.92 ± 0.81; Information, 3.91 ± 0.87. The majority of patients found the application to be relevant for their care. A total of 96% reported the information within the app was complete, while 4% estimated the information to be minimal or overwhelming. Patients (91.7%) overwhelmingly reported that the quality of information as it pertained to SCD patients was relevant; only 8.3% found the application to be poorly relevant to SCD. Similarly, patients (91.7%) overwhelmingly rated both the application’s performance and ease of use positively. The large majority of participants (85.7%) found the application to be interesting to use, while 74% found it entertaining. All users found the application’s navigation to be logical and accurate with consistent and intuitive gestural design. We conclude that the OpPill application, specifically targeted to monitor opioid use and pain and opioid behavior in patients with Chronic Non-Cancer Pain, was feasible and rated by SCD patients as easy-to-use using a validated rating tool.
Daily Living Subjective Cognitive Decline Indicators in Older Adults with Depressive Symptoms: A Scoping Review and Categorization Using Classification of Functioning, Disability, and Health (ICF)
Authors: Komalasari Renata , Mpofu Elias , Prybutok Gayle , Ingman Stanley
Published: August 2022

(1) Background: This scoping review identifies subjective cognitive decline (SCD) indicators in ADLs and instrumental activities of daily living (IADLs) in older adults with depressive symptoms using the WHO International Classification of Functioning, Disability, and Health (ICF). (2) Methods: We searched Medline via Ebscohost, Pubmed, and PsycINFO for articles published on activities of daily living (ADL) indicators of SCD in older adults with depressive symptoms, published in English language journals from January 2011 to November 2021. Following the flow diagram, 2032 titles and abstracts were screened for relevance based on the Population, Concept, and Context inclusion and exclusion criteria. (3) Results: Eight articles provided evidence about the ADL indicators of SCD in older adults with depressive symptoms. The analysis yielded indicators based on low and high cognitively demanding tasks assessed on five different scales. Framed on the ICF categorization and coding system, the SCD-ADL indicators are personal care, mobility, and general tasks and demands; SCD-IADL indicators are mobility, general tasks and demands, learning and applying knowledge, domestic life, communication, major life areas, and community, social, and civic life. (4) Conclusion: Highly cognitively demanding activities present more difficulties for individuals with SCD, making IADLs a stronger predictor of SCD than ADLs.
Geocultural Landscape and Sustainable Development at Apano Meria in Syros Island, Central Aegean Sea, Greece: An Ecomuseological Approach for the Promotion of Geological Heritage
Authors: Tsipra Theodora , Drinia Hara
Published: August 2022

In order to create a cultural landscape, the number of different types of ecomuseums around the world, covering many sites, has recently increased. Their establishment aims at the protection of natural and cultural resources. The north area of Syros Island offers significant opportunities for the development of a museum model that promotes the sustainable development of the local community. The aim of this study is to investigate the feasibility of developing a museum model that promotes the sustainable development of the local community in Apano Meria, Syros Island, which is a representative site with natural, geological, and archaeological heritage. For this purpose, the engagement and participation of the local inhabitants was evaluated through various activities, the basic principles of which are based on the concepts of New Museology and, more specifically, those of ecomuseums. Qualitative research was carried out through on-site observations, including discussions, participant observation, documentation, and in-depth interviews with local people. This research revealed that, so far, the conservation of the Apano Meria landscape is mainly due to the action of local people, who have repeatedly been called upon to show strong resistance to external factors that threatened to alter it. In their long-term effort to preserve and protect the area, but also to develop it in terms of sustainable development, the idea of its possible future inclusion in the UNESCO Global Network of Geoparks was proposed.
NPK Fertilization of Serianthes Plants Influences Growth and Stoichiometry of Leaf Nutrients
Authors: Marler Thomas E.
Published: August 2022

The genus Serianthes has not received adequate research attention, leaving large gaps in the knowledge required to inform conservation decisions. For example, nutrient management protocols are not understood due to lack of research. Serianthes grandiflora, Serianthes kanehirae, and Serianthes nelsonii plants were grown in container culture to determine the influence of increasing edaphic nitrogen (N), phosphorus (P), or potassium (K) content on stem growth and leaf nutrient relations. Addition of N alone increased leaf N, stimulated stem height and diameter growth, increased leaf number, and reduced leaf tissue concentrations of most nutrients including P and K. Addition of K alone increased leaf K, did not influence stem growth, did not reduce N or P concentration, but caused substantial changes in leaf tissue stoichiometry. Addition of P alone increased leaf P, did not influence stem growth, did not reduce leaf N or K concentration, and exerted minimal influence on concentrations and stoichiometry of other nutrients. The results indicate that single element P fertilization may be used to mitigate P deficiencies of Serianthes saplings without the risk of causing substantial nutrient imbalances. This knowledge may be used to inform nutrient management decisions in Serianthes conservation projects.
Potential Use of Superabsorbent Polymer on Drought-Stressed Processing Tomato (Solanum lycopersicum L.) in a Mediterranean Climate
Authors: Cerasola Vito Aurelio , Perlotti Lorenzo , Pennisi Giuseppina , Orsini Francesco , Gianquinto Giorgio
Published: August 2022

Drought risk is significantly increasing as a consequence of climate change, and the Mediterranean basin will be among the most affected areas by water scarcity in Europe. The development of agronomic strategies enabling the reduction in drought stress in cultivated crops is, therefore, a crucial priority. Superabsorbent polymers (SAPs) are soil amendments capable to retain water and release it when drought occurs. In the present study, the ability of a commercial SAP to improve the drought tolerance of processing tomato (Solanum lycopersicum L.) was assessed on a commercial farm located in northern Italy. A strip plot experimental design was adopted, where three irrigation treatments (IRR100, IRR75, and IRR50, respectively, restituting 100%, 75%, and 50% of crop evapotranspiration) were combined with the application of the SAP (control vs. soil amended with SAP). No significant interaction was observed between irrigation treatments and SAP application in yield and quality traits. SAP application allowed for an average increase in tomato yield (+16.4%) and irrigation water use efficiency (IWUE) (+15.8%), determined by a higher number of marketable fruits. The irrigation strategy IRR75 + SAP maintained the same yield and quality as the full irrigation control (IRR100), increasing the IWUE by about 37%. The experiment demonstrated that, for processing tomatoes grown in the Mediterranean, it is possible to reduce the water supply by 25% when SAP amendment is applied to the soil.
Dynamic Changes on Floral Aroma Composition of the Three Species from Tilia at Different Flowering Stages
Authors: Bao Wenqin , Shen Yongbao
Published: August 2022

The floral aroma, sometimes known as an incorporeal gift of flowers, is one of the primary ornamental features of plants. Flowers of genus Tilia are fragrant and have great value for development and utilization. In this study, for the first time, headspace solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS) combined with chemometrics were used to analyze the dynamic variations of scent components of the three species from Tilia at different flowering stages. A total of 70 volatile components were detected, 43 aroma compounds were identified. The UpSet diagram displayed great variations in the amount of aroma components at various flowering stages for each species. Partial least squares discriminant analysis (PLS-DA) indicated the proximity of aroma composition characteristics and the significant components that can distinguish the three species from one another. Variable importance projection values (VIP) along with the Kruskal-Wallis non-parametric analysis were performed to identify 14 crucial aroma components, such as α-Farnesene, D-Limonene, Germacrene D, Linalool, etc. In the end, we discovered that, in sharp contrast to Tilia miqueliana Maxim., Tilia cordata Mill. may have a closely related phylogenetic relationship with Tilia tomentosa Moench. by evaluating the aroma similarity rates.
Can Even a Small Amount of Greenery Be Helpful in Reducing Stress? A Systematic Review
Authors: Gu Jiaqi , Liu Haixiao , Lu Hong
Published: August 2022

A positive experience of nature triggers beneficial mental and physical responses. Today, we live in a rapidly urbanizing world where access to nature is often limited. Against this backdrop, this systematic review investigated studies on the effectiveness of small-scale greenery for stress reduction. We searched EMBASE, Cochrane, Web of Science, Scopus, PubMed, and Science Direct, searching databases from inception to April 2022. Studies were screened against predetermined criteria, and the risk of bias was assessed using the Cochrane Handbook for Systematic Reviews of Interventions for RCTs and The Risk of Bias in Non-Randomized Studies of Interventions (ROBINS-I) tool. Of the 2500 records identified, we screened 1817 citations for eligibility, which included 13 RCT studies and 6 non-RCT studies. The studies were conducted in eight different countries. The study populations included office workers, students, senior citizens, and patients with specific diseases. Research has mainly focused on indoor greening, with relatively little research on small-scale outdoor greening. All included studies assessed the impact of the intervention on various stress reduction-related outcomes, with the most common stress measures being blood pressure and the State Trait Anxiety Inventory (STAI). Various beneficial effects of the interventions on human health were reported in all 19 studies, 15 of which reported positive effects on stress reduction. All included studies were at high risk of bias. It is recommended that future studies in this area take appropriate measures to reduce bias and improve quality in order to build a strong evidence-based medical foundation. According to our findings, even very small-scale greening, including indoor green walls and potted plants, may provide effective help for stress relief. Understanding the physiological and psychological benefits of small-scale greenery can help better provide more opportunities for urban residents to engage with nature in the context of dense urban trends, as well as provide some reference for urban design planning.
Walking Speed Assessed by 4-Meter Walk Test in the Community-Dwelling Oldest Old Population in Vietnam
Authors: Nguyen Anh Trung , Nguyen Huong Thi Thu , Nguyen Huong Thi Thanh , Nguyen Thanh Xuan , Nguyen Tam Ngoc , Nguyen Thu Thi Hoai , Nguyen Anh Lan , Pham Thang , Vu Huyen Thi Thanh
Published: August 2022

This study aims to provide data on usual walking speed in individuals aged 80 years or older and determine the association between walking speed and related factors in community-dwelling older adults. A cross-sectional study design was conducted to measure walking speed on community-dwelling elders aged 80 years or older in Soc Son district, Vietnam. Walking speed was assessed by a 4-Meter Walk Test with a usual-pace walking mode. Health-related characteristics of participants including risk of falls (The Timed Up and Go test, activities of daily living (ADL), instrumental activities of daily living (IADLs), cognitive impairment (Mini-Cog test) and frailty syndrome (The Reported Edmonton Frail Scale (REFS)). Multiple logistic regression was used to analyze the association between a slow walking speed and selected factors. A total of 364 older people were recruited, and the majority were female (65.4%). The overall average walking speed was 0.83 ± 0.27 m/s. The proportion of participants with a slow walking speed (<0.8 m/s) was 40.4%. Multiple logistic regression analyses showed that age, female, high fall risk (assessed by TUG test), ADL/IADL dependence and frailty syndrome had a negative effect on slow walking speed in this population. The results could provide useful reference data for further investigations and measures in clinical practice.
Factors Associated with Gastrointestinal Symptoms among Rotating Shift Nurses in South Korea: A Cross-Sectional Study
Authors: Hwang Sun-Kyung , Lee Yun-Ji , Cho Min-Eun , Kim Bo-Kyoung , Yoon Yea-In
Published: August 2022

Rotating shift work places a serious burden on nurses’ physical and psychological health. Gastrointestinal (GI) symptoms are a common complaint among shift workers. This study assessed GI symptoms and identified the associations between dietary habits, psychological status, and sleep quality among rotating shift nurses. Data from 125 female nurses in rotating shifts who worked at two tertiary hospitals in South Korea were collected using a questionnaire that included the Gastrointestinal Symptoms Questionnaire; the Dietary Habit Questionnaire; the Depression, Anxiety, Stress Scale (DASS)-21; and the Pittsburgh Sleep Quality Index (PSQI). All participants experienced various GI symptoms, and 47% of them complained of at least one severe GI symptom. There were significant differences in GI symptom scores according to the status of depression, anxiety, stress, and sleep quality. In multiple linear regression analysis, the factors associated with an increase in the occurrence and severity of GI symptoms were poor sleep quality and morbid anxiety and stress. The model explained power at 43.2%. As most nurses in rotating shifts experience GI symptoms, they should receive counseling and training programs at work to alleviate psychological symptoms, improve sleep quality, and pay more attention to their health status as well as GI symptom management.
Analysis of Sustainable Communication Patterns during the Telework Period in Western Romanian Corporations
Authors: Țigan Eugenia , Blaga Radu Lucian , Isac Florin-Lucian , Lungu Monica , Milin Ioana Anda , Tripa Florin , Gavrilaș Simona
Published: August 2022

The research was conducted in a particular context, the recent pandemic. It is a comparative study of the methods and quality of communication in global companies between 2021 and 2022. The corporations involved in the research are important providers of flexible production, quality, and logistics solutions that cover customers’ real needs. They are active in the automotive industry and units involved in mass production in the electronics industry, household appliances, and cosmetics industries. In their case, it was noted that to achieve operational objectives such as developing employee skills, using advanced technologies, and exceeding customer expectations, it is important to use innovative methods and tools such as single platforms, which allow access to the most important information from a distance, anywhere, anytime. It is significant that, according to the research, the preferred method of communication by employees, regardless of the existing conditions, is face-to-face. Primarily, this method is chosen because it provides an open area of interpersonal interaction. The participants observe non-verbal attitudes or can perceive emotions and feelings. Their personality can be identified through unintentional contact to obtain constructive feedback through guidance and counseling. Moreover, it can be formed and develop productive, intentional connections. Stakeholders’ efficient and effective open dialogs are encouraged in this sense.
Approaches to Peripheral Artery Disease in Diabetes: Are There Any Differences?
Authors: Achim Alexandru , Stanek Agata , Homorodean Călin , Spinu Mihail , Onea Horea Laurenţiu , Lazăr Leontin , Marc Mădălin , Ruzsa Zoltán , Olinic Dan Mircea
Published: August 2022

Peripheral artery disease (PAD) increases the risk of diabetes, while diabetes increases the risk of PAD, and certain symptoms in each disease increase the risk of contracting the other. This review aims to shed light on this harmful interplay between the two disorders, with an emphasis on the phenotype of a patient with both diabetes and PAD, and whether treatment should be individualized in this high-risk population. In addition, current guideline recommendations for the treatment of PAD were analyzed, in an attempt to establish the differences and evidence gaps across a population suffering from these two interconnected disorders.
High-Quality Development of Chinese Agriculture under Factor Misallocation
Authors: Qin Shuai , Han Zheying , Chen Hong , Wang Haokun , Guo Cheng
Published: August 2022

Optimizing factor allocation is the premise of promoting high-quality development of agriculture. Based on the panel data of 31 provinces in China from 2004 to 2020, this paper examines the relationship between factor mismatch and high-quality agricultural development. We found that the high-quality development level of China’s agriculture shows a state of fluctuation and improvement, but the overall level is relatively low and the inter-provincial difference is expanding. Factor mismatch significantly inhibited the improvement of agricultural high-quality development, and the inhibition effect showed obvious temporal and spatial heterogeneity. We also found that the allocation of factors in extreme cases will lead to a 0.01% inter-provincial difference in the high-quality agricultural development. However, with the optimization and upgrading of the agricultural industrial structure and the improvement of the agricultural science and technology, the inhibitory effect of factor mismatch on high-quality agricultural development is constantly weakening. The above conclusion still holds after a series of robustness tests. The conclusions of this paper enrich the theoretical literature on the influencing factors of high-quality agricultural development, and provide an empirical reference for the policy maker of reducing factor mismatch and promoting high-quality agricultural development.
The Effectiveness of a Leadership Subject Using a Hybrid Teaching Mode during the Pandemic: Objective Outcome and Subjective Outcome Evaluation
Authors: Chai Wenyu , Li Xiang , Shek Daniel T. L.
Published: August 2022

Positive youth development (PYD) is an innovative approach to protect students from mental health problems and promote their positive and holistic development. Although there are many studies on the beneficial effects of PYD programs on youth in high school and community contexts, it is not clear whether subjects adopting PYD principles can promote positive development for university students. Moreover, it is unclear whether such subjects are effective under COVID-19, where subjects are commonly taught via the “hybrid” mode (i.e., face-to-face plus online teaching). The present study examined students’ changes in the PYD, wellbeing, and desired graduate attributes after they had taken a leadership subject utilizing PYD principles taught by the “hybrid” mode (N = 630). Adopting the one-group pre-test and post-test design (i.e., objective outcome evaluation), we found that students showed significant positive improvement in PYD indicators, wellbeing, as well as desired graduate attributes. Additionally, students had high satisfaction with the course design and teaching staff, and perceived many benefits from this subject based on the subjective outcome evaluation conducted at the end of the subject. Results also showed that students’ satisfaction with the curriculum significantly and positively predicted their positive change in PYD indicators, indicating the convergence of subjective outcome evaluation and objective outcome evaluation. The results highlight the positive impacts of the hybrid mode leadership subject with PYD principles in higher education.
Can Digital Economy Promote Energy Conservation and Emission Reduction in Heavily Polluting Enterprises? Empirical Evidence from China
Authors: Zhang Rongwu , Fu Wenqiang , Kuang Yingxu
Published: August 2022

This paper examines the impact of digital economy on corporate energy conservation and emission reduction (CECER) using China’s A-share listed heavily polluting enterprises from 2012 to 2019 as a sample. Our results show that: (1) Digital economy can significantly increase CECER, and this effect is significant for mining and manufacturing enterprises, and less significant for power, heat production and supply enterprises; (2) Mechanism research shows that digital economy promotes CECER through enhancing the green technology innovation capability, easing the financing constraints, and boosting market competition; (3) Heterogeneity research indicates that the promotion of digital economy to CECER is more significant in economically developed regions and regions with less financial pressure from local governments. This paper clarifies the factors influencing CECER and provides empirical evidence for achieving digital economy development and government goals for CECER.
The Illness Experience of Long COVID Patients: A Qualitative Study Based on the Online Q&A Community Zhihu
Authors: Wang Yi , Bao Sheng , Chen Yubing
Published: August 2022

Long COVID is a public health problem that cannot be ignored, and it is critical to understand the long COVID patients’ living situations and support this group through their illness narratives. This study is based on grounded theory, and coded the self-produced texts of long COVID patients on the largest online Q&A community in China, Zhihu APP, in an attempt to explore the illness experiences of long COVID patients in China and to understand how they adapt to their illness and reconstruct their lives. The results show that patients face not only the threat of pain from the illness itself, but also social stigma and discrimination. Patients turn their illness experiences into motivation to move forward and reconstruct self and life by ‘pushing forward the biographical flows again’, ‘impression management’ and ‘self-compassion’. These findings can help policy-makers and medical institutions to provide timely and appropriate policy support and psychological assistance to patients with long COVID, to create a supportive and inclusive social environment, and to reduce discrimination and stigma against them.
Association between Sociodemographic Factors and Condom Use among Migrant Sex Workers in Chiang Mai, Northern Thailand
Authors: O’Connor Suji Yoo , Tangmunkongvorakul Arunrat , Srithanaviboonchai Kriengkrai , Sripan Patumrat , Banwell Cathy , Kelly Matthew
Published: August 2022

Thailand has the highest HIV burden in the Asia-Pacific region, with the majority of cases occurring in specific populations. Migrant Sex Workers (MSWs) in Thailand are an important population for HIV risk, yet there has been limited literature on this group and their protective sexual behavior. A cross-sectional study was conducted among 396 MSWs 18–49 years old from 23 sex work-identified venues in Chiang Mai. Participants were surveyed on their own sociodemographic information, health behavior, sexual risk behavior, quality of life, and depression. Male respondents were significantly younger than females (p = 0.003). Most respondents were from Myanmar and were ethnic Shan. In the month preceding the survey, 17.0% of MSWs had consistent condom use with regular partners, 53.7% with casual partners, and 87.9% with clients. Condom use was least practiced with regular partners and most practiced with clients (17% and 87.9%, respectively; p < 0.001). There was a significant positive association between condom use and starting high school (χ2 = 8.08, p = 0.018). Education was the only variable that was significantly correlated with condom use with any sexual partner (OR = 0.41; 95%CI 0.20–0.82). Findings of the study indicate that further efforts are needed to promote condom use among migrant sex workers and their sexual partners in Thailand.
Anatomical Characteristics of Extensor Hallucis Longus Tendon Variations and Its Clinical Implications: A Korean Cadaveric Study
Authors: Park Jeong-Hyun , Choi Yu-Jin , Lee Mijeong , Kim Digud , Kwon Hyung-Wook , Park Kwang-Rak , Park Sa-Beom , Cho Jaeho
Published: August 2022

The purpose of this study is to ascertain the morphological characteristics of the extensor hallucis longus (EHL) tendon variation using larger-scale dissection of Korean cadavers and to classify the types of variation along with incidence. A total of 158 feet from adult formalin-fixed cadavers (50 males, 29 females) were dissected. The morphological characteristics and measurements of the EHL tendon variants were evaluated. Three types of the EHL tendon variation were classified, wherein the most common type was Type 2 (106 feet, 67.1%), Type 3 (3 feet, 1.9%) was the rarest type, and Type 1 without accessory tendon was found in 49 feet (31.0%). Type 2K (11 feet, 7%) and Type 3K (1 foot, 0.6%) were described as new subtypes. The present study suggests morphological characteristics of the EHL tendon variation in Korean populations and high morphological variability of the EHL tendon along with the possibility of differences according to race or ethnicity and gender. Furthermore, a newly updated classification complemented by new subtypes of variation will help foot and ankle surgeons in diagnosis and surgical planning with hallux problems.
Influence of Initial Severity of Depression on the Effectiveness of a Multimodal Therapy on Depressive Score, Heart Rate Variability, and Hemodynamic Parameters
Authors: Ketelhut Sascha , Wehlan Emanuel , Bayer Gerhart , Ketelhut Reinhard G.
Published: August 2022

Depression is a major cause of disability among populations worldwide. Apart from primary symptoms, depressed patients often have a higher cardiovascular risk profile. Multimodal therapy concepts, including exercise, have emerged as promising approaches that not only improve depressive symptoms but also have a positive impact on cardiovascular risk profile. However, controversies have arisen concerning the influence of baseline severity on the effects of therapy concepts for this demographic. This study assessed whether pretreatment severity moderates psychological and physiological treatment outcomes of a multimodal therapy. A total of 16 patients diagnosed with mild depression (MD) and 14 patients diagnosed with severe depression (SD) took part in a 3-month outpatient multimodal treatment therapy. Before and after the treatment, depression score (Beck Depression Inventory (BDI)), peripheral systolic (pSBP) and diastolic (pDBP) blood pressure, central systolic (cSBP) and diastolic (cDBP) blood pressure, pulse wave velocity (PWV), heart rate (HR), and parasympathetic parameters of heart rate variability (RMSSD) were assessed. Significant time effects were detected for BDI (−20.0 ± 11.6, p > 0.001, η2 = 0.871), pSBP (−4.7 ± 6.8 mmHg, p < 0.001, η2 = 0.322), pDBP (−3.5 ± 6.9 mmHg, p = 0.01, η2 = 0.209), cSBP (−4.8 ± 6.5 mmHg, p < 0.001, η2 = 0.355), cDBP (−3.6 ± 6.8 mmHg, p = 0.008, η2 = 0.226), PWV (−0.13 ± 0.23 m/s, p = 0.008, η2 = 0.229), HR (4.3 ± 8.8 min−1, p = 0.015, η2 = 0.193), RMSSD (−12.2 ± 23.9 ms, p = 0.017, η2 = 0.251), and and SDNN (10.5 ± 17.8 ms, p = 0.005, η2 = 0.330). Significant time × group interaction could be revealed for BDI (p < 0.001, η2 = 0.543), with patients suffering from SD showing stronger reductions. Pretreatment severity of depression has an impact on the effectiveness of a multimodal therapy regarding psychological but not physiological outcomes.
Landscape Perception and the Importance of Recreation Areas for Students during the Pandemic Time
Authors: Bernat Sebastian , Trykacz Karolina , Skibiński Jakub
Published: August 2022

The landscape and its perception influence the quality of life of a local community. Recreation areas bring a lot of benefits to society, also in terms of mental health. Open space and contact with nature, particularly during a crisis such as the pandemic, help alleviate the effects of the lockdown and social isolation. The study objective was to determine whether and to what extent the COVID-19 pandemic influenced the importance of recreation areas and the perception of landscape among students—a social group that experiences mood disorders increasingly often and has been severely affected by the lockdown. A survey was conducted in two stages, using a Google Forms online survey. A total of 381 students from universities in Lublin participated in the survey. The survey showed that the significance of recreation areas increased during the pandemic. The perception of landscape changed as well: the value of nature, scenic views, and the therapeutic effect of the landscape began to be appreciated to a greater extent. The survey results indicate the need to ensure the diversity of green areas and improve their accessibility. Designing these areas should also consider quiet areas as well as ensuring green mobility and places of recreation.
Educational Strategies to Promote Adherence to Treatment in Patients with Cardiovascular Disease
Authors: Martínez-Riera José , Aviles Gonzalez Cesar , Zambrano Bermeo Rosa , Curcio Felice , González Correa Julián , Estrada González Catalina , Melo Pedro , Galletta Maura
Published: August 2022

Introduction: Educational material is a key strategy for primary health care promotion. Purpose: To design and validate educational material adapted to the population and aimed to increase knowledge about adherence to the treatment of arterial hypertension and diabetes mellitus. Methodology: Methodological study for the design of educational material for people with diabetes mellitus and high blood pressure. For the design, content validity tests were carried out, with the participation of six experts in health education and six patients with chronic diseases. Validation was performed pursuant to the attraction, understanding, engagement, and acceptance criteria. Results: The validation confirmed that all items and criteria were above the minimal expected range. Conclusion: The design and validation of educational material provide elements that improve the education of patients about their pathologies and their adherence to treatment.
Effect of a Short Course on Improving the Cadres’ Knowledge in the Context of Reducing Stunting through Home Visits in Yogyakarta, Indonesia
Authors: Siswati Tri , Iskandar Slamet , Pramestuti Nova , Raharjo Jarohman , Rialihanto Muhammad Primiaji , Rubaya Agus Kharmayana , Wiratama Bayu Satria
Published: August 2022

Background: Stunting is primarily a public health concern in Low- and Middle-Income Countries (LMIC). The involvement of Integrated Health Service Post (Indonesian: Posyandu) cadres is among the strategies to combat stunting in Indonesia. Objective: This study aimed to determine the effect of a short course on cadres’ knowledge. Method: A single group pre-test post-test design was conducted in Yogyakarta, Indonesia, from March to May 2022. Thirty cadres were selected based on the following criteria: willingness to participate, the number of stunted children in their Posyandu, able to read and write, and full attendance at the short course. The knowledge scores were measured by a questionnaire using true and false answers after a short course (post-test 1) and 4 weeks later (post-test 2). We apply STATA 16 to calculate the Mean Difference (MD) using a t-test and a Generalized Estimated Equation (GEE). Furthermore, the adequacy of the short course was evaluated with in-depth interviews. Result: GEE analysis showed that after controlling for age, education, occupation, and years of experience, the short course improved cadres’ knowledge significantly on post-tests 1 and 2, i.e., knowledge regarding Children Growth Monitoring (CGM) (Beta = 6.07, 95%CI: 5.10–7.03 and Beta = 8.57, 95%CI: 7.60–9.53, respectively), Children Development Monitoring (CDM) (Beta = 6.70, 95%CI: 5.75–7.65 and Beta = 9.27, 95%CI: 8.31–10.22, respectively), and Infant Young Children Feeding (IYCF) (Beta = 5.83, 95%CI: 4.44–7.23 and Beta = 11.7, 95%CI: 10.31–13.09, respectively). Furthermore, the short course increased their self-efficacy, confidence, and ability to assist stunted children through home visits. Conclusion: The short courses consistently and significantly boosted cadres’ knowledge of CGM, CDM, and IYCF, and appropriately facilitated cadres in visits to the homes of stunted children’s home.
Comment on Alghnam et al. The Association between Obesity and Chronic Conditions: Results from a Large Electronic Health Records System in Saudi Arabia. Int. J. Environ. Res. Public Health 2021, 18, 12361
Authors: Alsarwani Rakan M.
Published: August 2022

I have read the interesting and informative paper recently published by Alghnam and colleagues that examined associations between obesity and diabetes (DM) and hypertension (HTN) [...]
Reply to Alsarwani, R.M. Comment on “Alghnam et al. The Association between Obesity and Chronic Conditions: Results from a Large Electronic Health Records System in Saudi Arabia. Int. J. Environ. Res. Public Health 2021, 18, 12361”
Authors: Alghnam Suliman , Alessy Saleh A. , Bosaad Mohamed , Alzahrani Sarah , Al Alwan Ibrahim , Alqarni Ali , Alshammari Riyadh , Al Dubayee Mohammed , Alfadhel Majid
Published: August 2022

We genuinely thank Dr. Alsarwani for his insights [...]