bluuebunny/crossref_metadata_2025 huggingface dataset:
Simplified numerical model development for advanced design of lightweight-concrete encased cold-formed steel shear wall panels
Authors: Eid Nathalie , Joó Attila László
Published: November 2023

Since cold-formed steel (CFS) elements are susceptible to complex buckling phenomena that decrease their structural capability, many strengthening trends have been developed so far. One of these methods is the use of polystyrene aggregate concrete (PAC) as bracings in order to restrain the global and distortional buckling modes of CFS members, where a new structural system comprising CFS elements encased in PAC has been proposed. In this research, PAC-encased CFS shear panels have been investigated numerically, where a simplified finite element model was developed to predict the structural behavior and capacity of such members. This goal was achieved using ANSYS software, where a geometrically and materially nonlinear analysis with imperfections (GMNI) was used to solve the problem of PAC-encased CFS shear panels. The full detailed volume-contact element-based concrete model was replaced by spring elements perpendicular to the plate’s plane with equivalent properties, and beam elements that could represent the concrete block more accurately regarding the global lateral stiffness and shear resistance. Consequently, for this case, the combination of local and global stiffness of PAC could produce the actual shear behavior of PAC-filled wall panels. The developed model was validated against previous experimental tests from the literature. Parametric studies were conducted in terms of the imperfection amplitudes, the stiffness of springs and the properties of PAC. Finally, the structural performance of PAC-encased panels under combined axial and shear loading was examined, where the effect of different axial load levels on the lateral strength was determined, and an interaction equation was proposed.
A brief history of free parafermions
Authors: Batchelor Murray T. , Henry Robert A. , Lu Xilin
Published: November 2023

In this article we outline the historical development and key results obtained to date for free parafermionic spin chains. The concept of free parafermions provides a natural N-state generalization of free fermions, which have long underpinned the exact solution and application of widely studied quantum spin chains and their classical counterparts. In particular, we discuss the Baxter-Fendley free parafermionic Z(N) spin chain, which is a relatively simple non-Hermitian generalization of the Ising model.
Human-centered design of a smartphone-based self-test for HIV viral load monitoring
Authors: Rodriguez Natalia M. , Balian Lara , Tolliver Cealia , Kataki Ishita , Jesus Julio Rivera-De , Linnes Jacqueline C.
Published: November 2023

Background/Objective:

HIV viral load self-testing could enable people living with HIV (PLHIV) to monitor their viral suppression status more easily, potentially facilitating medication adherence and safe behavior decision-making. Smartphone-based viral load testing innovations have the potential to reach resource-limited and vulnerable communities to address inequities in access to HIV care. However, successful development and translation of these tests requires meaningful investigation of end-user contexts and incorporation of those context-specific needs early in the design process. The objective of this study is to engage PLHIV and HIV healthcare providers in human-centered design research to inform key design and implementation considerations for a smartphone-based HIV viral load self-testing device prototype in development.

Methods:

Semi-structured in-depth interviews were conducted with PLHIV (n = 10) and HIV providers (n = 4) in Indiana, a state with suboptimal viral suppression rates and marked disparities in access to HIV care. Interview guides were developed based on contextual investigation and human-centered design frameworks and included a demonstration of the device prototype with feedback-gathering questions.

Results:

Thematic analysis of interview transcripts revealed important benefits, concerns, and user requirements for smartphone-based HIV VL self-testing within the context of PLHIV lived experience, knowledge, and barriers to care in Indiana.

Conclusion:

End-user needs and preferences were identified as key design specifications and implementation considerations to facilitate the acceptability and inform ongoing development and ultimately real-world translation of the HIV VL monitoring device prototype.
Natural parasitism of the coffee leaf miner: climate factors, insecticide, and landscape affecting parasitoid diversity and their ecosystem services in coffee agroecosystems
Authors: Santos Mateus P. dos , Neto Benício de M. S. , Cardoso Ana C. P. , Santos Iuri dos , Coelho Beatriz S. , Leite Suzany A. , Fernandes Daniell R. R. , Carvalho Geraldo A. , Castellani Maria A.
Published: November 2023

Climate factors, pesticides, and landscape in coffee agroecosystems directly affect the populations of the coffee leaf miner and its parasitoids. This study aimed to investigate the effects of climate factors, insecticide use, and landscape on natural parasitism, parasitoid diversity, and infestation ofL.coffeellain coffee plantations in the Planalto region, Bahia, Brazil. Mined leaves were collected monthly in six coffee plantations with varying edge density, vegetation cover, landscape diversity in scales of 500 to 3000 m of radius, insecticide use, and climate factors.Closterocerus coffeellae, andProacrias coffeae(Eulophidae) predominated in the pest's natural parasitism. Our record is the first for the occurrence ofStiropius reticulatus,Neochrysocharissp. 1,Neochrysocharissp. 2, andZagrammosomasp. in Bahia. Higher temperature and larger forest cover increased the coffee leaf miner infestation. Higher rainfall values, insecticide use, and landscape diversity decreased the pest infestations. Natural parasitism and species diversity are favoured by increase in temperature, forest cover, and edge density, while increase in rainfall, insecticide use, and landscape diversity lead them to decrease.The natural parasitism and diversity of parasitoid species of the coffee leaf miner have been enhancing in the areas with greater forest cover and edge density associated with low use of insecticides. The areas composed of different lands with annual croplands surrounding the coffee plantations showed less natural parasitism and parasitoid species diversity. The ecosystem services provided byC.coffeellaeandP.coffeaein coffee crops areas require conservation and these species are potential bioproducts for applied biological control programmes.
Examining psychotic experiences in two generations – findings from a rural household-based cohort study; the Lolland-Falster Health Study
Authors: Rimvall Martin Køster , Simonsen Erik , Zhang Jiawei , Andersen Zorana Jovanovic , Hastrup Lene Halling , Jeppesen Pia , Austin Stephen F. , Koch Susanne Vinkel
Published: November 2023

Background

Psychotic disorders are highly heritable, yet the evidence is less clear for subclinical psychosis expression, such as psychotic experiences (PEs). We examined if PEs in parents were associated with PEs in offspring.

Methods

As part of the Danish general population Lolland-Falster Health Study, families with youths aged 11–17 years were included. Both children and parents reported PEs according to the Psychotic Like Experiences Questionnaire, counting only ‘definite’ PEs. Parents additionally reported depressive symptoms, anxiety, and mental wellbeing. The associations between parental and child PEs were estimated using generalized estimating equations with an exchangeable correlation structure to account for the clustering of observations within families, adjusting for sociodemographic characteristics.

Results

Altogether, 984 youths (mean age 14.3 years [s.d. 2.0]), 700 mothers, and 496 fathers from 766 households completed PEs-questionnaires. Offspring of parents with PEs were at an increased risk of reporting PEs themselves (mothers: adjusted risk ratio (aRR) 2.42, 95% CI 1.73–3.38; fathers: aRR 2.25, 95% CI 1.42–3.59). Other maternal problems (depression, anxiety, and poor mental well-being), but not paternal problems, were also associated with offspring PEs. In multivariate models adjusting for parental problems, PEs, but not other parental problems, were robustly associated with offspring PEs (mothers: aRR 2.25, 95% CI 1.60–3.19; fathers: aRR 2.44, 95% CI 1.50–3.96).

Conclusions

The current findings add novel evidence suggesting that specific psychosis vulnerability in families is expressed at the lower end of the psychosis continuum, underlining the importance of assessing youths’ needs based on psychosis vulnerability broadly within the family systems.
The Use of Celtic Coinage in Early Roman London: A Re-interpretation of Bloomberg Wax Tablet 31
Authors: Johnson Tom
Published: November 2023

The reference to ‘victoriati’ in Bloomberg Wax Tablet 31 has been interpreted as a request for 52 Roman quinarii. This paper argues that quinarii were not available in significant enough quantities to make such a payment and that a more credible alternative is to see these ‘victoriati’ as a reference to local, Celtic coinage, specifically the silver issues of Epaticcus or Cunobelin. This identification, supported by recent metallurgic studies, alongside data from hoards, excavations and the Portable Antiquities Scheme, suggests a more prolonged use of Celtic coinage in Roman London than has previously been appreciated. Supplementary material is available online and provides data supporting the assertions made.
Contextualising Counterfeits: Roman Coin Moulds in Britain and the Channel Islands
Authors: Hingley Richard
Published: November 2023

This paper addresses the archaeological contexts of the clay moulds used to produce copies of Roman coins in third-century Britain. Previous research has focused primarily upon the technology and chronology of the use of moulds to produce coins with the discarded remains of the used moulds considered as ‘waste’ items from an industrial process. This paper focuses attention on the deposition of the moulds. Using the best-recorded finds, it builds upon earlier suggestions that disused moulds were regularly discarded in boundary locations (settlement boundaries, field boundaries, drainage features, shafts/wells, coastal locations and disused structures). It proposes that the magical and ritual associations of production meant that the clay moulds, in addition to the coins that were produced, required careful handling.
Effects of multi-gradient equilibration during vitrification on oocyte survival and embryo development in mice
Authors: Zhu Yan , Zhang Zhen , Zhang Guang-Li , Jiang Man-Xi
Published: November 2023

Vitrification has been widely used for oocyte cryopreservation, but there is still a need for optimization to improve clinical outcomes. In this study, we compared the routine droplet merge protocol with modified multi-gradient equilibration vitrification for cryopreservation of mouse oocytes at metaphase II. Subsequently, the oocytes were thawed and subjected to intracytoplasmic sperm injection (ICSI). Oocyte survival and spindle status were evaluated by morphology and immunofluorescence staining. Moreover, the fertilization rates and blastocyst development were examined in vitro. The results showed that multi-gradient equilibration vitrification outperformed droplet merge vitrification in terms of oocyte survival, spindle morphology, blastocyst formation, and embryo quality. In contrast, droplet merge vitrification exhibited decreasing survival rates, a reduced proportion of oocytes with normal spindle morphology, and lower blastocyst rates as the number of loaded oocytes increased. Notably, when more than six oocytes were loaded, reduced oocyte survival rates, abnormal oocyte spindle morphology, and poor embryo quality were observed. These findings highlight that the vitrification of mouse metaphase II oocytes by the modified multi-gradient equilibration vitrification has the advantage of maintaining oocyte survival, spindle morphology, and subsequent embryonic development.
Neural correlates of cross-alphabetic interference and integration in the biliterate brain
Authors: Bermúdez-Margaretto Beatriz , Myachykov Andriy , Fu Yang , Kopytin Grigory , Shtyrov Yury
Published: November 2023

We investigated the neurophysiological mechanisms underlying bi-alphabetic reading using event-related potentials (ERPs). Brain activity was recorded using EEG in a group of Russian–English biliterates during a reading-aloud task with familiar and novel words. Capitalizing on a partial overlap between the Roman and Cyrillic alphabets, the stimuli were presented in L1 Cyrillic, L2 Roman, or in an ambiguous script, in a counterbalanced fashion. The results revealed functional dissociation between the stimuli in terms of processing their graphemic ambiguity. The interference caused by L1-L2 script inconsistencies in novel wordforms was detected at a late processing stage, reflected in N400 response enhancement for unfamiliar script-ambiguous items. Conversely, familiar ambiguous and L2 words showed no N400 increase but demonstrated an early enhancement of the P200 component in comparison to those presented in L1. These results indicate the use of a whole-word reading strategy for familiar words even in ambiguous script, likely triggered by an automatic activation of well-established lexico-semantic representations. The absence of similar top-down mechanisms for novel ambiguous-script words likely results in increased grapheme-to-phoneme decoding effort, with important implications for L2 reading and vocabulary acquisition.
Are Initiatives an End-Run Around the Legislative Process? Divided Government and Voter Support for California Initiatives
Authors: Cummins Jeff
Published: November 2023

Interest groups and policy advocates often view the initiative process as a way to circumvent a gridlocked state legislative process. A major assumption behind this strategy is that this alternative path can be successful. We theorize that the same conflict and lack of consensus that killed the legislation in the legislative process may resurface in the electorate and jeopardize the measure’s chances of success at the ballot box. We test this proposition on all initiatives in California from 1912 to 2020 and on a smaller subset of the data that controls for campaign spending and the economy. We find clear and consistent evidence that voter support for initiatives, especially fiscal initiatives, declines under periods of divided government. In addition, interactive models show that increasing levels of party polarization exacerbate these effects. We conclude by discussing the implications of these results for the debate about whether the initiative process makes states more responsive to constituent opinion.
Plasticulture banana pepper response to clomazone applied pretransplanting
Authors: Arana Jeanine , Meyers Stephen L. , Cooper Emmanuel , Medina Castro Luis F. , Cerritos Josué , López Carlos A.
Published: November 2023

Few published studies exist documenting banana pepper tolerance to clomazone. Therefore, field trials were conducted in 2022 at two Indiana locations [Meigs Horticulture Research Farm and the Pinney Purdue Agricultural Center (PPAC)] to evaluate crop safety in plasticulture-grown banana pepper. The experimental design was a split-plot in which the main plot factor was the clomazone rate (0, 840, and 1,680 g ai ha–1) and the subplot factor was cultivar (‘Pageant’ and ‘Sweet Sunset’). Clomazone was applied over the top of black polyethylene mulch-covered raised beds and their respective bare-ground row middles 1 d prior to transplanting 12 pepper plants per subplot. Data collected included crop injury on a scale from 0% (no injury) to 100% (crop death) at 2, 4, and 6 wk after treatment (WAT), and plant stand. Two harvests were performed in which mature fruits were counted and weighed. Injury presented as interveinal bleaching only at PPAC 2 and 4 WAT. At this location 1,680 g ha–1 clomazone resulted in greater injury to ‘Sweet Sunset’ at 2 and 4 WAT (53% and 15%, respectively) than to ‘Pageant’ (19% and 3%, respectively); however, plant stand and yield were not affected by either clomazone rate. These results suggest that the clomazone rate range currently used for bell pepper (280 to 1,120 g ai ha–1) can be applied prior to transplanting plasticulture-grown banana pepper with minimal crop injury and without reducing yield.
Kann man Nähe und Distanz lernen?
Authors: Hahn Birgit , Pohl Leon , Kaya Muhammed , Saoud Khalil , Bouamer Hakim , Rixe Jacqueline
Published: November 2023

Was ist zu diesem Thema bereits bekannt?

Das Thema Nähe und Distanz ist hochrelevant für die (psychiatrische) Pflegepraxis. Obgleich curricular in der Pflegeausbildung verankert, ist das Thema für Berufseinsteiger_innen sehr abstrakt und schwer zu greifen.

Wie wird eine neue Perspektive eingebracht?

Im Rahmen eines strukturierten Einarbeitungsprogramms, dem Traineeprogramm in Psychiatrischer Pflege (TiPP), entstand ein Bild, das zur Veranschaulichung dieses abstrakten Themas genutzt wurde.

Was sind Auswirkungen für die Praxis?

Die Bearbeitung des Themas im TiPP verdeutlichte dessen Relevanz besonders während des ersten Jahres im Pflegeberuf. Das Arbeiten mit einer Metapher und der Austausch über eigene Erfahrungen wurden als sehr hilfreich erlebt.
Fate and Changes in Moisture Evaporated From the Tibetan Plateau (2000–2020)
Authors: Zhang Chi , Chen Deliang , Tang Qiuhong , Huang Jinchuan
Published: November 2023

Total evaporation from the vast terrain of the Tibetan Plateau (TP) may strongly influence downwind regions. However, the ultimate fate of this moisture remains unclear. This study tracked and quantified TP‐originating moisture using an extended Eulerian model. The findings reveal that the involvement of moisture from the TP in the downwind precipitation is most pronounced near the eastern boundary of the TP and gradually diminishes eastward. Consequently, the TP moisture ratio in precipitation reaches the highest of over 30% over the central‐eastern TP. 44.9%–46.7% of TP annual evaporation is recycled over the TP, and 65.1%–66.8% of the TP evaporation is reprecipitated over terrestrial China. Moisture recycling of TP origin shows strong seasonal variation, with seasonal patterns largely determined by precipitation, evaporation and wind fields. High levels of evaporation and precipitation over the TP in summer maximize local recycling intensity and recycling ratios. Annual precipitation of TP origin increased mainly around the northeastern TP during 2000–2020. This region consumed more than half of the increased TP evaporation. Further analyses showed that changes in reprecipitation of TP origin were consistent with precipitation trends in nearby downwind areas: when intensified TP evaporation meets intensified precipitation, more TP moisture is precipitated out. The model estimated an annual precipitation recycling ratio (PRR) of 26.9%–30.8% in forward moisture tracking. However, due to the non‐closure issue of the atmospheric moisture balance equation, the annual PRR in backward tracking can be ∼6% lower.
Magnetic Anomaly Grid and Associated Uncertainty From Marine Trackline Data: The Caribbean Alternative Navigation Reference Experiment (CANREx)
Authors: Saltus R. W. , Chulliat A. , Meyer B. , Bates M. , Sirohey A.
Published: November 2023

Crustal magnetic anomaly maps over oceanic regions are based largely on marine trackline surveys. These surveys, collected from the 1950s to the present, span a wide range of data quality and reliability. We discuss a methodology for constructing grids from these data with associated cell by cell estimates of grid uncertainty. The method is tested with a modern airborne survey for a representative region in the eastern Caribbean. The results are promising, producing an uncertainty estimate that is accurate to one standard deviation for the test area. As magnetic anomaly maps and grids are increasingly applied as constraints for geologic interpretation as well as for alternative navigation (e.g., navigation by magnetic field patterns in the absence of GPS), it is important to quantify the accuracy of these maps.
Urban Versus Lake Impacts on Heat Stress and Its Disparities in a Shoreline City
Authors: Chakraborty TC. , Wang Jiali , Qian Yun , Pringle William , Yang Zhao , Xue Pengfei
Published: November 2023

Shoreline cities are influenced by both urban‐scale processes and land‐water interactions, with consequences on heat exposure and its disparities. Heat exposure studies over these cities have focused on air and skin temperature, even though moisture advection from water bodies can also modulate heat stress. Here, using an ensemble of model simulations covering Chicago, we find that Lake Michigan strongly reduces heat exposure (2.75°C reduction in maximum average air temperature in Chicago) and heat stress (maximum average wet bulb globe temperature reduced by 0.86°C) during the day, while urbanization enhances them at night (2.75 and 1.57°C increases in minimum average air and wet bulb globe temperature, respectively). We also demonstrate that urban and lake impacts on temperature (particularly skin temperature), including their extremes, and lake‐to‐land gradients, are stronger than the corresponding impacts on heat stress, partly due to humidity‐related feedback. Likewise, environmental disparities across community areas in Chicago seen for skin temperature are much higher (1.29°C increase for maximum average values per $10,000 higher median income per capita) than disparities in air temperature (0.50°C increase) and wet bulb globe temperature (0.23°C increase). The results call for consistent use of physiologically relevant heat exposure metrics to accurately capture the public health implications of urbanization.
Geographical Trapping of Synchronous Extremes Amidst Increasing Variability of Indian Summer Monsoon Rainfall
Authors: Tantary Danish , Tangirala Arun K. , Murthugudde Raghu , Ghosh Subimal , Kumar Rohini , Bhatia Udit
Published: November 2023

Concurrent extreme rainfall events, or synchronous extremes, during Indian Summer Monsoon Rainfall (ISMR), cause significant damage, but their spatiotemporal evolution remains unclear. Using the event synchronization approach to examine the synchronicity of extreme rainfall events from 1901 to 2019, we find that Central India consistently hosts strongly connected synchronous extreme hubs with localized connections, indicating the geographical trapping of these concurrent events in the region. We observe a moderate positive correlation between network cohesiveness and El Niño Southern Oscillations (ENSO), and a negative correlation between ENSO and link lengths, suggesting localized synchronicity during El Niño dominant decades and opposite patterns in La Niña periods. Despite increasing ISMR variability and spatial nonuniformity, the persistence of hubs and network attributes could offer insights for predicting synchronous extremes, informing effective adaptation and risk management strategies during the monsoon season.
Time Resolved Reflectivity Measurements of Convective Clouds
Authors: Dolan Brenda , Kollias Pavlos , van den Heever Susan C. , Rasmussen Kristen L. , Oue Mariko , Luke Edward , Lamer Katia , Treserras Bernat P. , Haddad Ziad , Stephens Graeme , Chandrasekar V.
Published: November 2023

National Aeronautics and Space Administration's Investigations of Convective Updrafts (INCUS) mission aims to document convective mass flux through changes in the radar reflectivity (ΔZ) in convective cores captured by a constellation of three Ka‐band radars sampling the same convective cells over intervals of 30, 90, and 120 s. Here, high spatiotemporal resolution observations of convective cores from surface‐based radars that use agile sampling techniques are used to evaluate aspects of the INCUS measurement approach using real observations. Analysis of several convective cells confirms that large coherent ΔZ structure with measurable signal (>5 dB) can occur in less than 30 s and are correlated with underlying convective motions. The analysis indicates that the INCUS mission radar footprint and along track sampling are adequate to capture most of the desirable ΔZ signals. This unique demonstration of reflectivity time‐lapse provides the framework for estimating convective mass flux independent from Doppler techniques with future radar observations.
Statistical Study on Spatial Distribution of Frequency‐Chirping ECH Elements by Van Allen Probes
Authors: Liu Si , Chen Yadan , Yang Qiwu , Yang Hongming , Xiao Fuliang , Wang Bowen , Gao Zhonglei
Published: November 2023

Electron cyclotron harmonic (ECH) waves can scatter electrons into the atmosphere causing diffuse aurora with diffusion coefficients depending on the wave frequency. Here we report the Van Allen Probe observations of chirping ECH elements, which are fine structures with a frequency‐chirping rate of ∼kHz/s. 1,834 samples are identified in the 51‐month database and over 93 percent of them exhibit a falling tone pattern. ECH elements cover a broad region from 18 Magnetic Local Time (MLT) through dawn to 14 MLT with L = 4 − 7, and mainly occur in the region of 00–07 MLT with L = 5 − 6. More ECH elements are observed with the occurrence region extending to lower L‐shells during the geomagnetic activity period. Chirping ECH elements can propagate to |MLAT| ∼ 20°, but be confined by the contour of magnetic field strength. The statistical results can be applied on the global simulation of ECH‐induced electron penetration.
Climatology, Long‐Term Trend and Solar Response of Na Density Based on 28 Years (1990–2017) of Midlatitude Mesopause Na Lidar Observation
Authors: She Chiao‐Yao , Krueger David A. , Yan Zhao‐Ai , Yuan Tao , Smith Anne K.
Published: November 2023

The climatology of earth's Na density over Fort Collins, CO (41°N, 105°W) based on nocturnal Na lidar observations between 1990 and 1999 was reported by She et al. (2000, https://doi.org/10.1029/2000gl003825). Based on a continued 28‐year data set between 1990 and 2017 with the latter part observed over Logan, UT (42N, 112W), we update the seasonal variations between 80 and 110 km. This data set is also used to deduce long‐term responses of Na density (profile) between 75 and 110 km, showing a positive linear trend between 75 and 93 km (with maximum ∼2.87 × 108 m−3/decade at 87 km); it turns negative before approaching zero at 110 km (with minimum ∼−2.96 × 107 m−3/decade at 100 km). The associated solar response is also positive for the altitude range in question (with maximum ∼5.20 × 106 m−3/SFU at 91 km). We also derived the 28‐year mean Na layer column abundance, centroid altitude, and root mean square width to be 3.92 ± 2.14 1013 m−2, 91.3 ± 1.0 km, and 4.62 ± 0.56 km, respectively, and deduced long‐term trend and solar cycle responses of column abundance and centroid altitude, respectively to be 7.81 ± 1.63%/decade and 16.9 ± 2.8%/100SFU, and −355 ± 35 m/decade and −1.94 ± 0.69 m/SFU. We explained conceptually how positive long‐term responses in Na density led to positive responses in column abundance and negative responses in centroid altitude.
Unifying VLF Transmitter and Sferic Modeling Efforts Via Tomography
Authors: Richardson David K. , Cohen Morris B.
Published: November 2023

We demonstrate a methodology for utilizing measurements from very low frequency (VLF, 3−30 kHz) transmitters and lightning emissions to produce 3D lower electron density maps, and apply it to multiple geophysical disturbances. The D‐region lower ionosphere (60−90 km) forms the upper boundary of the Earth‐ionosphere waveguide which allows VLF radio waves to propagate to global distances. Measurements of these signals have, in many prior studies, been used to infer path‐average electron density profiles within the D region. Historically, researchers have focused on either measurements of VLF transmitters or radio atmospherics (sferics) from lightning. In this work, we build on recently published methods for each and present a method to unify the two approaches via tomography. The output of the tomographic inversion produces maps of electron density over a large portion of the United States and Gulf of Mexico. To illustrate the benefits of this unified approach, daytime and nighttime maps are compared between a sferic‐only model and the new approach suggested here. We apply the model to characterize two geophysical disturbances: solar flares and lower ionospheric changes associated with thunderstorms.
Targeted Observations on Arctic Sea Ice Concentration for Improving Extended‐Range Prediction of Ural Blocking
Authors: Gao Yangjiayi , Mu Mu , Dai Guokun
Published: November 2023

The predictability of certain extreme weather events can exceed the traditional 2 weeks by considering the boundary conditions. Targeted observations in sensitive areas (SA) on Arctic sea ice concentration (SIC) can improve the extended‐range (4 pentads) forecast skills of long‐lasting and strong Ural blocking (UB). The SA are determined based on the SIC optimally growing boundary errors, obtained by the conditional nonlinear optimal perturbation method. The SA are mainly located in the Barents Sea, Greenland Sea, and Okhotsk Sea. The results of observing system simulation experiments for 8 UB cases indicate that the targeted observations can remarkably improve the prediction skills of UB in the fourth pentad. Targeted observations have a positive effect on 75% of 160 experiment members, reduce 35% forecast errors of the fourth pentad mean blocking index, and perform even better when the original forecast errors are greater. Further diagnosis shows that targeted observations contribute to more accurate SIC boundary conditions in the Barents Sea, Greenland Sea, and Okhotsk Sea and reduce temperature errors in the lower and middle troposphere. It further results in well‐described westerly winds in the Ural region and its adjacent regions, corresponding to the more skillful predictions of blocking circulations. The above results supply a theoretical base for the design of Arctic SIC observations and more skillful extended‐range predictions for mid‐latitude extreme weather.
Changes in perceptions of antibiotic stewardship among neonatal intensive care unit providers over the course of a learning collaborative: a prospective, multisite, mixed-methods evaluation
Authors: Qureshi Nabeel , Kroger Jack , Zangwill Kenneth M. , Joshi Neha S. , Payton Kurlen , Mendel Peter
Published: November 2023

Objective

To assess clinician perceptions towards the value and implementation of antibiotic stewardship (AS) in neonatal intensive care units (NICU).

Study design

We performed a mixed-methods study of AS perceptions (prescribing appropriateness, importance, activity, capacity) using surveys and interviews in 30 California NICUs before and after a multicenter collaborative (Optimizing Antibiotic Use in California NICUs [OASCN]).

Results

Pre-OASCN, 24% of respondents felt there was “a lot of” or “some” inappropriate prescribing, often driven by fear of a bad outcome or reluctance to change existing practice. Clinicians reported statistically significant increases in AS importance (71 v 79%), perceived AS activity (67 v 87%), and more openness to change after OASCN (59 v 70%). We identified other concerns that lessen AS effort.

Conclusion

OASCN increased perceived AS activity and openness to change in AS practices among NICU prescribers. Greater attention to subjective concerns should augment AS improvement.
LUBAC is required for RIG-I sensing of RNA viruses
Authors: Teague Helena C. , Lefevre Charlotte , Rieser Eva , Wolfram Lina , de Miguel Diego , Patricio de Oliveira Daniel , Oliveira Marisa , Mansur Daniel S. , Irigoyen Nerea , Walczak Henning , Ferguson Brian J.
Published: November 2023

The ability of cells to mount an interferon response to virus infections depends on intracellular nucleic acid sensing pattern recognition receptors (PRRs). RIG-I is an intracellular PRR that binds short double-stranded viral RNAs to trigger MAVS-dependent signalling. The RIG-I/MAVS signalling complex requires the coordinated activity of multiple kinases and E3 ubiquitin ligases to activate the transcription factors that drive type I and type III interferon production from infected cells. The linear ubiquitin chain assembly complex (LUBAC) regulates the activity of multiple receptor signalling pathways in both ligase-dependent and -independent ways. Here, we show that the three proteins that constitute LUBAC have separate functions in regulating RIG-I signalling. Both HOIP, the E3 ligase capable of generating M1-ubiquitin chains, and LUBAC accessory protein HOIL-1 are required for viral RNA sensing by RIG-I. The third LUBAC component, SHARPIN, is not required for RIG-I signalling. These data cement the role of LUBAC as a positive regulator of RIG-I signalling and as an important component of antiviral innate immune responses.
Exploring the genetic and molecular basis of differences in multiple myeloma of individuals of African and European descent
Authors: Levine Arnold J. , Carpten John D. , Murphy Maureen , Hainaut Pierre
Published: November 2023

Multiple Myeloma is a typical example of a neoplasm that shows significant differences in incidence, age of onset, type, and frequency of genetic alterations between patients of African and European ancestry. This perspective explores the hypothesis that both genetic polymorphisms and spontaneous somatic mutations in the TP53 tumor suppressor gene are determinants of these differences. In the US, the rates of occurrence of MM are at least twice as high in African Americans (AA) as in Caucasian Americans (CA). Strikingly, somatic TP53 mutations occur in large excess (at least 4–6-fold) in CA versus AA. On the other hand, TP53 contains polymorphisms specifying amino-acid differences that are under natural selection by the latitude of a population and have evolved during the migrations of humans over several hundred thousand years. The p53 protein plays important roles in DNA strand break repair and, therefore, in the surveillance of aberrant DNA recombination, leading to the B-cell translocations that are causal in the pathogenesis of MM. We posit that polymorphisms in one region of the TP53 gene (introns 2 and 3, and the proline-rich domain) specify a concentration of the p53 protein with a higher capacity to repress translocations in CA than AA patients. This, in turn, results in a higher risk of acquiring inactivating, somatic mutations in a different region of the TP53 gene (DNA binding domain) in CA than in AA patients. Such a mechanism, by which the polymorphic status of a gene influencing its own “spontaneous” mutation frequency, may provide a genetic basis to address ethnicity-related differences in the incidence and phenotypes of many different forms of cancer.
Trunk orthosis with joints providing resistive force improves dynamic sagittal alignment in postoperative patients with lumbar spinal stenosis
Authors: Igawa Tatsuya , Ishii Ken , Katsuhira Junji , Suzuki Akifumi , Ui Hideto , Urata Ryunosuke , Isogai Norihiro , Sasao Yutaka , Matsudaira Ko , Funao Haruki
Published: November 2023

This study aimed to determine whether a trunk orthosis with joints providing resistive force (TORF) modifies sagittal malalignment during level walking in patients with lumbar spinal stenosis (LSS). Fifteen patients, 6 months after undergoing surgery for LSS, performed level walking at a self-selected speed while wearing a TORF. Dynamic sagittal alignment, including sagittal vertical axis, lumbar lordosis, and pelvic tilt, and spatiotemporal data as well as lower limb kinematic and kinetic data were recorded using a three-dimensional motion analysis system and six force plates. Statistical analysis was performed to compare these data with and without the TORF, respectively. Compared to the condition without the TORF, the use of the TORF significantly decreased positive sagittal vertical axis (p < 0.05) and increased the lumbar lordosis and pelvic tilt (p < 0.05). Peak hip flexion angle and extension moment during loading response (LR) significantly increased (p < 0.05), and peak hip extension angle and flexion moment during PS statistically decreased (p < 0.05). There was no difference in spatiotemporal data between the two conditions. Our findings suggest that TORF may modify the dynamic sagittal global alignment and lower limb kinematic and kinetics in postoperative LSS patients during level walking.
Exposure to social bots amplifies perceptual biases and regulation propensity
Authors: Yan Harry Yaojun , Yang Kai-Cheng , Shanahan James , Menczer Filippo
Published: November 2023

Automated accounts on social media that impersonate real users, often called “social bots,” have received a great deal of attention from academia and the public. Here we present experiments designed to investigate public perceptions and policy preferences about social bots, in particular how they are affected by exposure to bots. We find that before exposure, participants have some biases: they tend to overestimate the prevalence of bots and see others as more vulnerable to bot influence than themselves. These biases are amplified after bot exposure. Furthermore, exposure tends to impair judgment of bot-recognition self-efficacy and increase propensity toward stricter bot-regulation policies among participants. Decreased self-efficacy and increased perceptions of bot influence on others are significantly associated with these policy preference changes. We discuss the relationship between perceptions about social bots and growing dissatisfaction with the polluted social media environment.
Adaptation constraints in scenarios of socio-economic development
Authors: Theokritoff Emily , van Maanen Nicole , Andrijevic Marina , Thomas Adelle , Lissner Tabea , Schleussner Carl-Friedrich
Published: November 2023

Climate change adaptation is paramount, but increasing evidence suggests that adaptation action is subject to a range of constraints. For a realistic assessment of future adaptation prospects, it is crucial to understand the timescales needed to overcome these constraints. Here, we combine data on documented adaptation from the Global Adaptation Mapping Initiative with national macro indicators and assess future changes in adaptation constraints alongside the Shared Socioeconomic Pathways, spanning a wide range of future socio-economic development scenarios. We find that even in the most optimistic scenario, it will take until well after 2050 to overcome key constraints, which will limit adaptation for decades to come particularly in vulnerable countries. The persistence of adaptation constraints calls for stringent mitigation, improved adaptation along with dedicated finance and increasing efforts to address loss and damage. Our approach allows to ground truth indicators that can be further used in climate modelling efforts, improving the representation of adaptation and its risk reduction potential.
Prospective association of occupational and leisure-time physical activity with orthostatic blood pressure changes in older adults
Authors: Kujawska Agnieszka , Kujawski Sławomir , Dani Melanie , Miglis Mitchell G. , Hallman David M. , Fudim Marat , Soysal Pinar , Husejko Jakub , Hajec Weronika , Skierkowska-Kruszyńska Natalia , Kwiatkowska Małgorzata , Newton Julia L. , Zalewski Paweł , Kędziora-Kornatowska Kornelia
Published: November 2023

Orthostatic hypotension (OH) is common in older people. We examined the influence of self-reported occupational-related physical activity (PA) and leisure-time physical exercise (PE) on orthostatic response in a sample of older people over a 2 year period. Supine and orthostatic systolic blood pressure (sBP), diastolic blood pressure (dBP), and mean blood pressure (mBP) were assessed in response to Active Stand (AS) test in 205 older subjects (> 60 years old) at baseline and 2-year follow-up. OH was found in 24 subjects (11.71%) at baseline and 20 subjects (9.76%) after 2 years, with a significant degree of variability in the occurrence of OH after 2 years. Twenty-two subjects who had OH at baseline were free of it after 2 years, two subjects had persistent OH at baseline and after 2 years. After 2 years, adults with occupational PA showed no significant decrease of blood pressure in response to AS test, while lack of undertaking an occupation-related PA was significantly related with a greater decrease in sBP and mBP in response to AS testing in the 1st min. Occupation-related PA and leisure-time-related PE were related to an increase in the response of BP on AS in change between baseline and after 2 years. High between-subjects variance in OH over 2 years was noted. Occupations that involved continuous physical activity and leisure-time physical exercise in middle age were both protective for BP decline on orthostatic stress test within 2 years.
White noise insole: an artificial evoked sensation device that can be expected to improve plantar sensation of diabetic foot
Authors: Jiang Yangzheng
Published: November 2023

Diabetic foot is a common severe complication of diabetes, and its main symptom is diabetic foot ulcer. The production of plantar diabetic foot ulcers is usually affected by two factors, namely neuropathy or vascular disease. While previous studies proved that stochastic resonance (SR) could effectively enhance the plantar touch of patients with diabetic feet, the potential impact of SR on neural circuit feedback, especially on the input of the tactile nerves of the lower limbs, is less clear. This study aims to explore the potential impact on the tactile threshold of the human foot when using vibrating insoles. We study a white noise vibration insole based on SR mechanism. We compare and analyze the tactile threshold voltage (TTV) triggered by an electrical stimulation device in three main plantar pressure-bearing areas (the second metatarsal (M2), the fourth metatarsal (M4), and the heel (H) area) of 8 participants using EEG and self-developed vibration insole. Significance found in M2 and M4 areas, white noise signal (WNS) lowered the tactile threshold in these areas, and had a potentially positive impact on patients with diabetic feet, especially in the M4 area. The influence of WNS on the plantar heel area was still controversial. This study showed that WNS applied to the sole could improve the plantar tactile sensing ability of patients with diabetic feet, but it did not cover all areas. The application of WNS showed better benefits for the forefoot area than for the hindfoot area, which was speculated that may be related to the difference in the distribution density of blood vessels in plantar areas. Due to the impaired natural touch in participants with diabetic foot, using artificial evoked sensation WNS intervention, would be a feasible approach to improve plantar sensation.
Targeted mutagenesis of Medicago truncatula Nodule-specific Cysteine-Rich (NCR) genes using the Agrobacterium rhizogenes-mediated CRISPR/Cas9 system
Authors: Güngör Berivan , Biró János Barnabás , Domonkos Ágota , Horváth Beatrix , Kaló Péter
Published: November 2023

The host-produced nodule specific cysteine-rich (NCR) peptides control the terminal differentiation of endosymbiotic rhizobia in the nodules of IRLC legumes. Although the Medicago truncatula genome encodes about 700 NCR peptides, only few of them have been proven to be crucial for nitrogen-fixing symbiosis. In this study, we applied the CRISPR/Cas9 gene editing technology to generate knockout mutants of NCR genes for which no genetic or functional data were previously available. We have developed a workflow to analyse the mutation and the symbiotic phenotype of individual nodules formed on Agrobacterium rhizogenes-mediated transgenic hairy roots. The selected NCR genes were successfully edited by the CRISPR/Cas9 system and nodules formed on knockout hairy roots showed wild type phenotype indicating that peptides NCR068, NCR089, NCR128 and NCR161 are not essential for symbiosis between M. truncatula Jemalong and Sinorhizobium medicae WSM419. We regenerated stable mutants edited for the NCR068 from hairy roots obtained by A. rhizogenes-mediated transformation. The analysis of the symbiotic phenotype of stable ncr068 mutants showed that peptide NCR068 is not required for symbiosis with S. meliloti strains 2011 and FSM-MA either. Our study reports that gene editing can help to elicit the role of certain NCRs in symbiotic nitrogen fixation.
Reconstructing signed relations from interaction data
Authors: Andres Georges , Casiraghi Giona , Vaccario Giacomo , Schweitzer Frank
Published: November 2023

Positive and negative relations play an essential role in human behavior and shape the communities we live in. Despite their importance, data about signed relations is rare and commonly gathered through surveys. Interaction data is more abundant, for instance, in the form of proximity or communication data. So far, though, it could not be utilized to detect signed relations. In this paper, we show how the underlying signed relations can be extracted with such data. Employing a statistical network approach, we construct networks of signed relations in five communities. We then show that these relations correspond to the ones reported by the individuals themselves. Additionally, using inferred relations, we study the homophily of individuals with respect to gender, religious beliefs, and financial backgrounds. Finally, we study group cohesion in the analyzed communities by evaluating triad statistics in the reconstructed signed network.
Metabolic regulation boosts bioelectricity generation in Zymomonas mobilis microbial fuel cell, surpassing ethanol production
Authors: Ahmadpanah Hananeh , Motamedian Ehsan , Mardanpour Mohammad Mahdi
Published: November 2023

Zymomonas mobilis (Z. mobilis), a bacterium known for its ethanol production capabilities, can also generate electricity by transitioning from ethanol production to electron generation. The purpose of this study is to investigate the ability of Z. mobilis to produce bioelectricity when utilized as a biocatalyst in a single-chamber microbial fuel cell (MFC). Given the bacterium's strong inclination towards ethanol production, a metabolic engineering strategy was devised to identify key reactions responsible for redirecting electrons from ethanol towards electricity generation. To evaluate the electroactivity of cultured Z. mobilis and its ethanol production in the presence of regulators, the reduction of soluble Fe(III) was utilized. Among the regulators tested, CuCl2 demonstrated superior effectiveness. Consequently, the MFC was employed to analyze the electrochemical properties of Z. mobilis using both a minimal and modified medium. By modifying the bacterial medium, the maximum current and power density of the MFC fed with Z. mobilis increased by more than 5.8- and sixfold, respectively, compared to the minimal medium. These findings highlight the significant impact of metabolic redirection in enhancing the performance of MFCs. Furthermore, they establish Z. mobilis as an active electrogenesis microorganism capable of power generation in MFCs.