bluuebunny/crossref_metadata_2025 huggingface dataset:
Cartography Theory and Map Service Model Based on Constructivism
Authors: Duo Tianlin , Zhang Peng
Published: November 2021

Map is not only the result of geospatial environment cognition, but also a tool for geospatial environment cognition. The new concept advocated by Constructivist cognitive theory is highly consistent with the concept of map service in the era of Internet plus space-time big data. This paper analyzes the geographic information transmission process from the perspective of constructivism, and constructs the geographic information transmission process model. Based on the traditional map cognitive process model, a map cognitive process model based on constructivism is constructed. According to the four elements of “situation, cooperation, communication and meaning construction” advocated by Constructivist cognitive theory, a map service function model based on constructivism is constructed.
THE EFFECT OF ACUPRESSUR THERAPY IN REDUCING NAUSEA AND VOMITING PREGNANT WOMEN TRIMESTER I : QUASI-EXPERIMENTAL STUDY
Authors: Suryani Suryani , Murtiyarini Ika , Suryanti Yuli , Misnanda Misnanda
Published: November 2021

Introduction: Nausea and vomiting are the most common symptoms experienced by pregnant women in the first trimester, and these symptoms are experienced by 70-85% of women. Nausea and vomiting are often experienced by pregnant women, especially in the first trimester, affecting about 50-80% of pregnant women. Management of nausea and vomiting in pregnancy consists of pharmacological and non-pharmacological. This study aims to analyze the effect of acupressure therapy on nausea and vomiting. Methods: This type of research is a quasi-experimental design using a two-group pre-post design involving 30 first trimester pregnant women who experience nausea and vomiting selected by purposive sampling. The criteria for the participants were gestational age at 10-16 weeks and maternal age at 20-35 years (productive age), while mothers taking nausea and vomiting drugs were excluded from this study. Data analysis used the Wilcoxon test and Mann-Withney test. Results: a significant decrease group with p-value <0.05. Based on the Mann Whitney test, it was found that the p-value for the pre in the frequency of moderat nausea and vomiting scores before and after acupressure in the intervention -test (<0.0001), and the post-test was 0.55, post test scores showed no difference between the two study groups. Conslusion: The study shows encouraging signs about reducing the frequency of nausea and vomiting in first-trimester pregnant women, so this therapy can be used as an alternative intervention for pregnant women who experience nausea and vomiting.
TO FIND OUT ETIOLOGY AND CLINICAL PROFILE OF PATIENTS OF ACUTE KIDNEY INJURY AT TERTIARY CARE CENTRE OF INDORE
Authors: Meena Kiran , Goyal Nikita , Verma Anjali , Mukhariya Rahul , Lad Divyesh
Published: November 2021

Background & Method: Present Study was done with an aim to find out Etiology and clinical profile of patients of Acute Kidney Injury at Tertiary Care Centre of Indore. After taking institutional ethical clearance and written consent from the patients a cross sectional observational study was conducted on 100 Patients admitted in Intensive Care Unit of INDEX MEDICAL COLLEGE AND RESEARCH CENTRE who have clinical and / or biochemical evidence of acute kidney injury, detailed thorough history taking, general physical examination, systemic examination and routine and specific lab investigations, were done to find out the underlying etiology, clinical features and outcome of Acute Kidney Injury.

Result: This study includes various etiology of acute kidney injury in the current study. Most common cause being AGE (30%) followed by septicemia (16%) and poisoning (14%). In present study 75 % of cases were of Pre Renal AKI. Post Renal and Renal AKI was present in 13% and 12% respectively.

Conclusion: The variety of clinical features were recorded and studied, the most commonly observed clinical feature was oliguria closely followed by malaise and vomiting in acute kidney injury. Acute gastrointestinal infection was the most common cause of acute kidney injury. Other frequent causes were septicemia, poisoning, multi organ dysfunction syndrome.

Keywords: Etiology, clinical & Acute Kidney.
Recepción de la subtitulación para personas sordas de los informativos españoles
Authors: Tamayo Ana , De los Reyes Lozano Julio , Martí Ferriol José Luis
Published: November 2021

Este es un estudio sobre la recepción de la subtitulación para personas sordas (SPS) en directo y semidirecto de informativos españoles. Este tiene como objetivo analizar la comprensión y la opinión de usuarios con discapacidad auditiva. Se seleccionó un corpus real y relevante para la investigación y se reclutó una muestra de 52 sujetos con discapacidad auditiva para la realización del experimento, que se llevó a cabo en sesiones presenciales y virtuales. Se encontró que, aunque los usuarios consideren aceptable la calidad de los subtítulos, los resultados reflejan que la comprensión es insuficiente.
An Assessment of Inventory Management Practices at the Hospitality Management Department of Takoradi Technical University
Authors: Danso Bertha , Whyte Theodora Naa Maamle , Jnr. Peter Owusu-Akyaw , Fenteng Rita Adasi , Akyaa Loretta Akosua
Published: November 2021

Inventory management encompasses a wide variety of tasks. These tasks differ depending on the organization. The study's main goal is to evaluate inventory management activities at Takoradi Technical University's hospitality management department. Non–experimental analysis was used to design the sample. The study's target population was hospitality students with sample sizes of 60 students. Purposive sampling was used to collect data for the analysis. The analysis relied on primary data.  To collect data for the analysis, a structured questionnaire was created with both opened-ended and closed-ended questions. Statistical Package for Social Sciences (SPSS) and Microsoft Excel were used to analyze and process the information. Frequency distribution tables, pie charts, and bar charts were used to display the findings. According to the results, the department did a commendable job of resource management in order to provide supplies for the students' practical training. The department's inventory management process was purely commercial and the proper inventory management process was implemented. Regardless, it was recommended that the hospitality department strive to keep inventory under control. Evidence for inventory management and record documentation should also be handy at all times.
Penerapan Model Pembelajaran Inquiry untuk Meningkatkan Hasil Belajar Siswa pada Pelajaran Geografi dengan Materi Pokok Dinamika Kependudukan di Indonesia Kelas XI SMAN 10 Kota Jambi
Authors: Ermiwati Ermiwati
Published: November 2021

This research aims to determine the effectiveness of student learning outcomes in Geography subjects with the subject of Population Dynamics in Indonesia class XI IPS 1 SMAN 10 Jambi using inquiry learning model. Population and samples in this study were students of class XI IPS 1, amounting to 30 students. The data obtained based on this study Based on the results obtained in the above study between the two cycles it can be obtained data that in cycle 1 the average value of student learning activities in first cycle  was 2.6 while the average value in second cycle  was obtained. amounted to 3,4. This shows that there is an increase in student learning activities. Based on the results obtained in the above research, between the two cycles, it can be obtained data that in first cycle  the average value of teacher activity was 3.4, and the average value insecond cycle  was 3.5. This shows that there is an increase in teacher activity. Based on the results obtained in the above research, especially on the subject of  Population Dynamics in Indonesia, there are significant results on student learning completeness in first  cycle  and second cycle was 10%.
Pengembangan Media Pembelajaran Permainan Ular Tangga Edukatif Dalam Pembelajaran Sejarah Indonesia Masa Kolonialisme Dan Imperialisme Bangsa Eropa
Authors: Pamungkas Satriyo , Azmi Ulul
Published: November 2021

This study is to determine the development of educational media for playing snakes and ladders in learning the history of Indonesia during colonialism and European imperialism using the Lee and Owens model. This development model consists of five development stages, namely analysis, design, development, implementation, and evaluation. From the process of these stages, the average score at the trial stage where the product went through three stages, namely one to one (2.58) in the poor category, the small group (4.2) in the very feasible category, and the field test (4, 45) in the very category worth it. Overall from the results of these trials, the mean score was 3.74 categories (feasible).
Upaya Meningkatkan Hasil Belajar Matematika dengan Menggunakan Aplikasi Google Classroom Siswa Kelas X IPA 1 SMA N 3 Kerinci
Authors: Violeta Dien
Published: November 2021

Penelitian ini bertujuan untuk meningkatkan hasil belajar peserta didik kelas X MIPA 1 SMA Negeri 3 Kerinci dengan memanfaatkan aplikasi google classroom sebagai salah satu upaya pembelajaran selama pandemi Covid-19 pada materi Trigonometri. Penelitian ini adalah penelitian tindakan kelas yang dilaksanakan selama dua siklus. Setiap siklus terdiri atas tahap perencanaan (planning), tindakan (action), pengamatan (observation), dan refleksi (reflection). Upaya pembelajaran yang digunakan dengan memanfaatkan aplikasi google classroom. Kelebihan dari aplikasi ini adalah dapat mempermudah guru dalam mengelola pembelajaran dan menyampaikan informasi secara tepat dan akurat kepada peserta didik. Hasil dari penelitan ini menunjukkan bahwa upaya pembelajaran dengan memanfaatkan teknologi berupa aplikasi google classroom selama pandemi Covid-19 dapat meningkatkan hasil belajar peserta didik pada materi Trigonometri Kelas X MIPA 1 SMA Negeri 3 Kerinci, Hasil analisis data, ketuntasan hasil belajar matematika pada siklus 1 dengan rata-rata nilai 72 atau 64%, pada siklus 2 menunjukkan peningkatan dengan capaian ketuntasan 84 atau 88%. Hal ini menunjukkan bahwa target persentase ketuntasan peserta didik telah melebihi dari nilai batas minimal. Oleh Karena itu disarankan kepada guru mata pelajaran matematika agar menggunakan teknologi aplikasi google classroom sebagai salah satu solusi untuk mengatasi permasalahan dalam belajar matematika terutama pada materi Trigonometri.
Koperasi Swadaya Untuk Meningkatkan Aktivitas Ekonomi dan Kesejahteraan Warga Dusun Parit Panjang Desa Jambi Tulo
Authors: Indah Sari Pratiwi , Indra Yudha Redi
Published: November 2021

Koperasi semata-mata bertujuan untuk meningkatkan taraf hidup, baik dalam hal ekonomi maupun sosial para anggota maupun pengguna koperasi. Warga Dusun Parit Panjang Desa Jambi Tulo aktivitas perekonomian hanya tergantung pada hasil perkebunan, atau menjadi buruh yang bekerja pada salah perusahaan sehingga cenderung terlibat dengan para tengkulak atau rentenir apabila kekurangan modal maupun uang untuk memenuhi kebutuhan sehari-hari. Para warga memiliki keinginan untuk mendirikan sebuah lembaga koperasi yang lebih baik bercermin dari kegagalan sebelumnya. Dengan demikian, dapat dikatakan bahwa keinginan tidak dapat merubah suatu kondisi ataupun keadaan apabila tidak didukung dengan wawasan dan pengetahuan, disamping terdapat dasar hukum dalam mengatur sebuah kegiatan atau aktivitas ekonomi yang berhubungan dengan kesejahteraan masyarakat banyak.
The Effect of Using Zoom Conference System on Students’ Speaking Skills
Authors: Daud Wahyudi , Nofa Rama Asri
Published: November 2021

he objective of this study is to investigate the effects of using zoom conference system on students’ speaking skill. This research is classified into pre-experimental research that uses one group pre-test and post-test. In the one group pre-test and post-test design, a single group is measured or observed not only after being treatment, but also before the treatment. The data of this research analyzed by using Statistical Package for the Social Science (SPSS, version 24.0) where the data of this study include quantitative data, namely students speaking skill on pre-test and post-test. Therefore, the data are analyzed by using descriptive statistic, while to test the hypothesis, the researcher used Paired Sample t-test to draw the conclusion whether or not it is accepted. The finding revealed that Zoom conferencing strategy has a noteworthy impact on students’ Speaking Skill. The probability value (p value) is less than the level of significant which p value is 0.000 < 0.05 (alpha value). Means, there is difference mean score on pre-test and post-test in experimental class.
Hubungan Persepsi Mahasiswa tentang Mata Kuliah Kewirausahaan dan Hasil Belajar dengan Minat Berwirausaha Mahasiswa Reguler Angkatan 2013 Pendidikan Ekonomi
Authors: Rosmiati Rosmiati , Saputra Hutabarat Zuhri
Published: November 2021

Setiap mahasiswa mempunyai perhatian khusus terhadap mata kuliah tertentu, hal tersebut dapat dilihat dari semangat dan minat belajar mahasiswa terhadap mata kuliah yang diminati oleh mahasiswa. Ada beberapa program mata kuliah yang diberikan kepada mahasiswa untuk membekali lulusan pendidikan ekonomi agar menjadi mandiri atau dapat berusaha sendiri. Tujuan dari penelitian yang dilakukan adalah mengetahui hubungan persepsi mahasiswa tentang mata kuliah kewirausahaan dan hasil belajar dengan minat berwirausaha mahasiswa reguler angkatan 2013 pendidikan ekonomi. Jenis penelitian ini adalah Korelasional. Subjek dalam penelitian ini adalah mahasiswa reguler angkatan 2013 Pendidikan Ekonomi sebanyak 44 orang. Data diperoleh dengan menyebarkan angket. Setelah itu dianalisis dengan korelasi parsial product moment dan korelasi ganda. Hasil penelitian ini menunjukkan bahwa persepsi mahasiswa tentang mata kuliah kewirausahaan berkriteria baik terhadap hasil belajar mahasiswa, serta memiliki minat berwirausaha yang tinggi. Penelitian ini juga menunjukkan hubungan yang tinggi dan signifikan antara antara persepsi mahasiswa tentang mata kuliah kewirausahaan dengan minat berwirausaha pada mahasiswa reguler angkatan 2013 pendidikan ekonomi ,yaitu sebesar rhitung 0,694. Terdapat hubungan signifikan antara hasil belajar dengan minat berwirausaha pada mahasiswa reguler angkatan 2013 pendidikan ekonomi, yaitu sebesar rhitung 0,703. Terdapat hubungan yang signifikan antara persepsi mahasiswa tentang mata kuliah kewirausahaan dan hasil belajar dengan minat berwirausaha pada mahasiswa reguler angjatan 2013 pendidikan ekonomi ,yaitu sebesar rhitung 0,740.
Implementation of the cluster economy concept in the accounting system
Authors: Hyk V.
Published: November 2021

The paper is devoted to the fundamental aspects of clustering the economy of Ukraine. This topic is important because modern economy of the developed countries, which was previously based on traditional forms, is now impossible without innovation clusters development. Therefore, the investigation of the transformation of innovation systems based on clusters under the influence of crises in the world economy and the consequences of the COVID-19 pandemic is very important scientific and practical task. The theoretical experience and essence of the organizational mechanism of cluster structures are considered in this paper. It is determined that the concept of cluster economy offers new types of interaction between business entities, government and other institutions that are interested in increasing competitiveness. Therefore, the study of the cluster approach should be based on theories investigating the relationship between competition and cluster models. It is established that economy clustering strengthens the relationships between economic entities and contributes to the regions competitiveness increase. It is the strengthening of ties between cluster members that promotes the implementation of innovations. Conceptual approaches to cluster structure management are considered. It is determined that the network form of management is based on the use as the subject of cluster management of an independent business unit, which replaces the functional management structures of independent association members. This form of management is based on the high level of trust between the cluster members, as well as on the development of relations between economic entities. The cluster formation requires appropriate changes in the field of management, and this, in turn, affects its main information carrier – the accounting system. The author emphasizes the need to create accounting and analytical support for the cluster management system. The accounting information system should reflect the facts of financial and economic activities of the integrated structure and provide management with the ability to make tactical and strategic decisions. That is why the development of accounting will contribute to obtain more complete and reliable information about the results of the cluster as a group of legally independent, but interconnected in economic and financial terms of organizations.
Formation of the financial and economic security system at the enterprise
Authors: Dovgal A. , Parkhomenko N.
Published: November 2021

The necessity of formation of financial and economic security at the enterprise in modern conditions of unstable financial situation in the country is defined. The concept of «financial and economic security» is substantiated, especially that financial and economic security is the financial and economic condition of the enterprise, through which the financial and economic interests of the company should be protected from negative external and internal factors and create the necessary financial and economic conditions for continuous successful activity and sustainable development of the enterprise. Statistics on the difficult financial security situation for both enterprises and the country are presented. The main indicators of the system and components for the formation of financial and economic security at the enterprise are analyzed. It is determined that the main factors of financial and economic security of the enterprise are: the level of financial resources; stability and firmness of the financial condition of the enterprise; balance of financial flows; the nature of financial and economic activities of the enterprise and the degree of its efficiency. Stages of formation of financial and economic security are to determine the types and causes of negative impact on the company and determine its financial condition, assessment of the current level of its security. Indicators for assessing the efficiency of the enterprise and the current state of financial and economic security of the company are presented. All these measures are aimed at ensuring the balance and sustainability of financial and economic security of the company, which consists in the effective implementation of currency, investment, settlement, stock, monetary policies, etc. as a prerequisite for the effectiveness of economic activity of the business entity. The following ways of improvement of financial and economic system are offered: improvement of normative-legal protection of all spheres of activity; ensuring the reliability of staff; protection of information used by the enterprise; effective monitoring of finances and risks of financial activity; increasing financial stability and independence by ensuring the efficiency of core activities, competitiveness of products and / or services; the right choice of strategies for market behavior.
Estudio térmico en una vivienda situada en la ciudad de Guayaquil
Authors: Intriago Mairongo Holger Arturo , Gonzales Vega Alex Andrés , Rosero Obando Egner Manuel , Plaza Hernández Felipe Noé
Published: November 2021

El sector de la construcción es uno de los sectores que mayor impacto tiene en la economía del país; el presente trabajo busca determinar de forma exploratoria cuantitativa los parámetros más influyentes en el comportamiento térmico de una vivienda ubicada en un clima húmedo muy caluroso, para ello en el trabajo se realizó un estudio de flujo de calor en las paredes, piso y techo de una vivienda para tratar de disminuir el consumo energético del aire acondicionado y anunciarlas como eco-eficiente en la ciudad de Guayaquil - Ecuador, empleando materiales de construcción comunes de las viviendas, de acuerdo con el último censo del INEC, estos materiales son: bloque de concreto de 15 cm de espesor para paredes, concreto alivianado de 15 cm de espesor en el techo y concreto pesado de 20 cm en el piso; además, el 20% de las superficies de las paredes son acristaladas con ventanas de vidrio simple de 6 mm de espesor. Para ello se evaluarán las ganancias de calor por paredes y techos al medio día, tres horas antes y después del mediodía, para un día típico por efecto del calor sensible. Mediante la aplicación de métodos numéricos y con asistencia del software libre octave, se determina que la ganancia de color depende de la orientación de la vivienda con respecto al sol y del área más grande de pared.
Nimensä mukaisesti irtiotto
Authors: Raivola Reijo
Published: November 2021

Raimo Mäkinen & Olli Poropudas (toim.) Irtiotto 90-luvun koulutuspolitiikasta : koulutuspoliittinen artikkelikokoelma. (Turun yliopiston kasvatustieteiden tiedekunnan julkaisuja B:67).Turun yliopiston kasvatustieteiden laitos, 2001. 212 s. ISBN 951-29-1907-9
ANALSIS DAN PERANCANGAN KAMUS BAHASA ILMIAH TUMBUHAN BERBASIS ANDROID
Authors: Alfian Joni
Published: November 2021

The scientific name of living things, especially plants, is one of the things that is basically very interesting to learn and know, because the scientific name of living things provides an important role, among others with scientific names it will easily know the characteristics, relationships of relatives, and interactions of living things in the environment. Knowledge of plant classification has generally been taught to high school students and MIPA students or biology majors, but interest in learning about plant taxonomy is still low due to the source of information that is not yet widely available. Therefore, the development of learning media is needed one of them by building an android-based plant scientific language dictionary application that can be one of the alternative learning media for students and students. The algorithm applied is sequential search that performs search faster because the search process is already in order. That way the interest in learning students and students about the scientific language of plants can be encouraged by the spirit in learning by using this learning medium. Based on the research that has been done, the application of the scientific language dictionary of plants can be used by students, students and the public as a means of learning in understanding the scientific names on each plant that is equipped with the alphabetic menu a-z and plant categories and search features to make it easier for users to find plant names
IMPLEMENTASI GAME PERMAINAN TIMUN EMAS BERBASIS ANDROID
Authors: Setiadi Agung
Published: November 2021

This research was conducted on the basis of helping children to get to know about folklore in Indonesia. In addition, this study was conducted to help children in learning the moral values that exist in folklore. This research was conducted by creating an android-based game application with the theme of Gold Cucumber folklore. Children in Indonesia today have begun to forget the cultures that exist in their own country. One of the causes is the influx of foreign cultures that are becoming increasingly popular and starting to erode the indigenous culture of Indonesia. Therefore, the author created an android-based folklore-themed game application so that children can be interested in one of Indonesia's existing cultures. The app was tested using the black box method and the benefits of the application were studied using questionnaire and interview methods. After the application passed in black box testing, the application was tested and received a positive response from existing questionnaires and interviews. With the results of existing research, it can be concluded that this application can carry out its duties to help children in introducing folklore culture and educating moral values well.
PELATIHAN PENANGANAN CIDERA OLAHRAGA DI SMA NEGERI 1 PRINGSEWU
Authors: Fahrizqi Eko Bagus , Aguss Rachmi Marsheilla , Yuliandra Rizki
Published: November 2021

Kegiatan olahraga dengan cedera, terutama bagi para olahragawan atau atlet. Untuk itu kita harus berhati – hati dalam berolahraga agar tidak mengalami cedera. Sebelum berolahraga atau bermain usahakan melakukan pemanasan terlebih dahulu, kemudian setelah selesai melakukan pendinginan. Untuk mengurangi resiko terjadinya cedera. Cedera olahraga diartikan sebagai cedera yang terjadi akibat kegiatan olahraga baik secara langsung atau tidak langsung, yang mengenai sistem muskuloskeletal dan semua sistem atau organ lain yang memengaruhinya sehingga menimbulkan gangguan fungsi sistem tersebut.Ekstrakurikuler yang ada banyak di ikuti oleh siswa. Beberapa siswa yang bersekolah ada yang berlatar belakang atlet. Selain kegiatan latihan disekolah ada juga yang berlatih diluar jadwal sekolah. Sehingga dengan padatnya jadwal latihan tersebut, kurang lebih mempengaruhi kondisi badan. Banyak nya cedera olahraga dilapangan yang tidak ditangani dengan benar. Sport massage merupakan sebuah keahlian yang digunakan sebagai penanganan cedera pada olahraga. Oleh karena itu sport massage dapat digunakan sebagai alat terapi baik untuk pencegahan, kesehatan, dan penyembuhan penyakit. Dikarenakan masih banyak atlet kurang pengetahuan tentang penanganan cedera olahraga melalui sport massage. Berdasarkan kenyataan di atas, tim pengabdi merasa perlu untuk memberikan keterampilan massage bagi siswa yang mengikuti ekstrakurikuler Olahraga di SMAN 1 Pringsewu.Tujuan dari pengabdian pada masyarakat ini adalah: (1) Memberi bekal pengetahuan dan teori tentang massage bagi siswa yang mengikuti ekstrakurikuler Olahraga di SMAN 1 Pringsewu., (2) Membekali keterampilan massage untuk pencegahan, kesehatan, dan penyembuhan pada siswa yang mengikuti ekstrakurikuler Olahraga di SMAN 1 Pringsewu.
UPAYA PENINGKATAN KOSAKATA BAHASA INGGRIS MELALUI STORYTELLING SLIDE AND SOUND
Authors: Amelia Dina
Published: November 2021

Pendidikan diselenggarakan dengan memberi keteladanan, membangun kemauan, dan mengembangakan kreativitas peserta didik dalam proses pembelajaran. Anak adalah sosok individu yang sedang berkembang dengan pesat dan fundamental bagi kehidupan selanjutnya. Anak pada usia masa ini anak berada pada usia 0-10 tahun sedang mengalami masa yang cepat dalam perkembangan hidup manusia (Uzer, 2019). Sekolah Tunas Mekar Indonesia adalah sekolah national plus yang menggunakan bahasa pengantar bahasa Inggris. Akan tetapi, sejak masa pandemic Covid 19 dan pembelajaran online dimulai, kemampuan siswa untuk dapat memahami materi dan menghafal kosakata serta berbicara dalam bahasa Inggris menurun, terutama anak-anak di kelas 5 SD. Permasalahan tersebut juga dipicu oleh metode pembelajaran yang tidak bervariasi. Metode ceramah dan tanya jawab merupakan hal yang paling seering digunakan di ruang kelas.  Metode yang digunakan tim PkM Sastra Inggris Universitas Teknokrat Indonesia demi meningkatan kosakata bahasa Inggris adalah melalui storytelling Slide and Sound. Sebagian besar peserta pelatihan PkM Storytelling Slide and Sound memberikan respon cepat dan tepat sehingga mengalami peningkatan kosakata cukup signifikan selama masa pelatihan. Sementara Sebagian kecil siswa masih mengalami kesulitan dalam Menyusun kata dikarenakan kurangnya kosakata. Akan tetapi, semua siswa merassakan dampak positif dan semua siswa mau bekerjasama dan mencoba metode belajar tersebut.
Ti spiego il mio problema: un'indagine sulle competenze argomentative nella risoluzione di problemi matematici
Authors: Avenia Monica
Published: November 2021

Diversi studiosi hanno di recente approfondito la competenza argomentativa applicata a processi di problem solving da parte degli studenti già dagli ultimi anni della scuola dell’infanzia. In questo articolo viene presentata un’indagine effettuata in una classe III primaria di Imola (Bologna) durante l’anno scolastico 2018/2019, avente come focus di interesse l’analisi dell’argomentazione durante la risoluzione di problemi. Ci si riferisce nello specifico al problem solving quale approccio alla risoluzione di tre problemi matematici prendendo come riferimento metodologico il Progetto ArAl e il Rally Matematico Transalpino, nei quali emerge l’importanza di tale approccio all’interno delle prassi didattiche in matematica, con attenzione al linguaggio specifico della disciplina e all’utilizzo dell’argomentazione per sviluppare e riconoscere i processi emotivi e metacognitivi tramite il ragionamento e la riflessione.
Introduzione alla modellizzazione matematica nella scuola secondaria di secondo grado
Authors: Moser Antonella
Published: November 2021

Nell’ambito della didattica della matematica, i modelli matematici sembrano avere scarsa attenzione, nonostante il loro crescente sviluppo e utilizzo nel mondo reale. Nella prassi didattica spesso si presenta un modello già costruito, chiedendo agli studenti di quantificare grandezze che vi compaiono per rispettare determinate condizioni. Rimane il dubbio che quest’unico approccio aiuti effettivamente a interiorizzare il concetto di modello e a capirne l’importanza e l’efficienza come strumento matematico.Quest’esperienza didattica stimola gli studenti a costruire un modello matematico descrittivo di una situazione basata su un gioco competitivo per introdurre le peculiarità della modellizzazione matematica. Seppur circoscritta a un certo tipo di modello matematico, l’esperienza evidenzia i passi fondamentali per realizzare un qualsiasi modello. In particolare, si pone una certa attenzione a far sì che gli studenti siano il più possibile autonomi proprio nella costruzione del modello, in modo che possano sviluppare un approccio consapevole e critico alla modellizzazione matematica.
Nanotechnology-Based Weapons to Combat Human Papillomavirus Infection Associated Diseases
Authors: Pan Luyao , Li Bingxin , Chen Jiahua , Zhang Haofeng , Wang Xi , Shou Jiahui , Yang Dejun , Yan Xiaojian
Published: November 2021

Persistent human papillomavirus (HPV) infection will eventually lead to clinical problems, varying from verrucous lesions to malignancies like cervical cancer, oral cancer, anus cancer, and so on. To address the aforementioned problems, nanotechnology-based strategies have been applied to detect the virus, prevent the interaction between virus and mammalian cells, and treat the virus-infected cells, due mainly to the unique physicochemical properties of nanoparticles. In this regard, many nanotechnology-based chemotherapies, gene therapy, vaccination, or combination therapy have been developed. In this Minireview, we outline the pathogenesis of HPV infection and the recent advances in nanotechnology-based weapons that can be applied in combating HPV-associated diseases.
A Pro-Inflammatory Gut Microbiome Characterizes SARS-CoV-2 Infected Patients and a Reduction in the Connectivity of an Anti-Inflammatory Bacterial Network Associates With Severe COVID-19
Authors: Reinold Johanna , Farahpour Farnoush , Fehring Christian , Dolff Sebastian , Konik Margarethe , Korth Johannes , van Baal Lukas , Hoffmann Daniel , Buer Jan , Witzke Oliver , Westendorf Astrid M. , Kehrmann Jan
Published: November 2021

The gut microbiota contributes to maintaining human health and regulating immune responses. Severe COVID-19 illness is associated with a dysregulated pro-inflammatory immune response. The effect of SARS-CoV-2 on altering the gut microbiome and the relevance of the gut microbiome on COVID-19 severity needs to be clarified. In this prospective study, we analyzed the gut microbiome of 212 patients of a tertiary care hospital (117 patients infected with SARS-CoV-2 and 95 SARS-CoV-2 negative patients) using 16S rRNA gene sequencing of the V3-V4 region. Inflammatory markers and immune cells were quantified from blood. The gut microbiome in SARS-CoV-2 infected patients was characterized by a lower bacterial richness and distinct differences in the gut microbiome composition, including an enrichment of the phyla Proteobacteria and Bacteroidetes and a decrease of Actinobacteria compared to SARS-CoV-2 negative patients. The relative abundance of several genera including Bifidobacterium, Streptococcus and Collinsella was lower in SARS-CoV-2 positive patients while the abundance of Bacteroides and Enterobacteriaceae was increased. Higher pro-inflammatory blood markers and a lower CD8+ T cell number characterized patients with severe COVID-19 illness. The gut microbiome of patients with severe/critical COVID-19 exhibited a lower abundance of butyrate-producing genera Faecalibacterium and Roseburia and a reduction in the connectivity of a distinct network of anti-inflammatory genera that was observed in patients with mild COVID-19 illness and in SARS-CoV-2 negative patients. Dysbiosis of the gut microbiome associated with a pro-inflammatory signature may contribute to the hyperinflammatory immune response characterizing severe COVID-19 illness.
Fast-Strain Encoded Cardiac Magnetic Resonance During Vasodilator Perfusion Stress Testing
Authors: Steen Henning , Montenbruck Moritz , Kelle Sebastian , Esch Sebastian , Schwarz Arne Kristian , Giusca Sorin , Korosoglou Grigorios
Published: November 2021

Background: Cardiac magnetic resonance perfusion imaging during vasodilator stress is an established modality in patients with suspected and known coronary artery disease (CAD).

Aim: This study aimed to evaluate the performance of fast-Strain-Encoded-MRI (fast-SENC) for the diagnostic classification and risk stratification of patients with ischemic heart disease.

Methods: Perfusion and fast-SENC cardiac magnetic resonance (CMR) images were retrospectively analyzed in 111 patients who underwent stress CMR. The average myocardial perfusion score index, global and segmental longitudinal and circumferential strain (GLS and GCS and SLS and SCS, respectively), were measured at rest and during stress. The combination of SLS and SCS was referred to as segmental aggregate strain (SAS). Segments exhibiting perfusion defects or SAS impairment during stress were defined as “ischemic.” All-cause mortality, non-fatal infarction, and urgent revascularization were deemed as our combined clinical endpoint.

Results: During adenosine stress testing, 44 of 111 (39.6%) patients exhibited inducible perfusion abnormalities. During a mean follow-up of 1.94 ± 0.65 years, 25 (22.5%) patients reached the combined endpoint (death in n = 2, infarction in n = 3 and urgent revascularization in n = 20). Inducible perfusion defects were associated with higher number of segments with inducible SAS reduction ≥6.5% (χ2 = 37.8, AUC = 0.79, 95% CI = 0.71–0.87, p < 0.001). In addition, patients with inducible perfusion defects or SAS impairment exhibited poorer outcomes (AUCPerf = 0.81 vs. AUCSAS = 0.74, p = NS vs. each other, and χ2 = 30.8, HR = 10.3 and χ2 = 9.5, HR = 3.5, respectively, p < 0.01 for both).

Conclusion: Purely quantitative strain analysis by fast-SENC during vasodilator stress was related to the diagnosis of ischemia by first-pass perfusion and is non-inferior for the risk stratification of patients with ischemic heart disease. This may bear clinical implications, especially in patients with contraindications for contrast agent administration.
Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis
Authors: Gong Boshen , Wang Chuyuan , Meng Fanrui , Wang Haoyu , Song Bo , Yang Yang , Shan Zhongyan
Published: November 2021

Background

Autoimmune thyroid disease (AITD) is characterized by thyroid dysfunction and deficits in the autoimmune system. Growing attention has been paid toward the field of gut microbiota over the last few decades. Several recent studies have found that gut microbiota composition in patients with AITD has altered, but no studies have conducted systematic reviews on the association between gut microbiota and ATID.

Methods

We searched PubMed, Web of Science, Embase, and Cochrane databases without language restrictions and conducted a systematic review and meta-analysis of eight studies, including 196 patients with AITD.

Results

The meta-analysis showed that the alpha diversity and abundance of certain gut microbiota were changed in patients with AITD compared to the controls. Chao1,the index of the microflora richness, was increased in the Hashimoto’s thyroiditis group compared to controls (SMD, 0.68, 95%CI: 0.16 to 1.20), while it was decreased in the Graves’ disease group (SMD, -0.87, 95%CI: -1.46 to -0.28). In addition, we found that some beneficial bacteria like Bifidobacterium and Lactobacillus were decreased in the AITD group, and harmful microbiota like Bacteroides fragilis was significantly increased compared with the controls. Furthermore, the percentage of relevant abundance of other commensal bacteria such as Bacteroidetes, Bacteroides, and Lachnospiraceae was increased compared with the controls.

Conclusions

This meta-analysis indicates an association between AITD and alteration of microbiota composition at the family, genus, and species levels.

Systematic Review Registration

PROSPERO, identifier CRD42021251557.
Genetic Diversity and Characteristics of blaNDM-Positive Plasmids in Escherichia coli
Authors: Zhang Zhiren , Guo Hengzhao , Li Xiaodong , Li Wenting , Yang Guang , Ni Wenjun , Zhan Meixiao , Lu Ligong , Zhang Zhenlin , Li Xiaobin , Zhou Zhiling
Published: November 2021

New Delhi metallo-β-lactamases (NDMs), including at least 28 variants, are a rapidly emerging family of β-lactamases worldwide, with a variety of infections caused by NDM-positive strains usually associated with very poor prognosis and high mortality. NDMs are the most prevalent carbapenemases in Escherichia coli (E. coli) worldwide, especially in China. The vast majority of blaNDM cases occur on plasmids, which play a vital role in the dissemination of blaNDM. To systematically explore the relationships between plasmids and blaNDM genes in E. coli and obtain an overall picture of the conjugative and mobilizable blaNDM-positive plasmids, we analyzed the variants of blaNDM, replicon types, phylogenetic patterns, conjugative transfer modules, host STs, and geographical distributions of 114 blaNDM-positive plasmids, which were selected from 3786 plasmids from 1346 complete whole genomes of E. coli from the GenBank database. We also established links among the characteristics of blaNDM-positive plasmids in E. coli. Eight variants of blaNDM were found among the 114 blaNDM-positive plasmids, with blaNDM–5 (74 blaNDM–5 genes in 73 plasmids), and blaNDM–1 (31 blaNDM–1 genes in 28 plasmids) being the most dominant. The variant blaNDM–5 was mainly carried by the IncX3 plasmids and IncF plasmids in E. coli, the former were mainly geographically distributed in East Asia (especially in China) and the United States, and the latter were widely distributed worldwide. IncC plasmids were observed to be the predominant carriers of blaNDM–1 genes in E. coli, which were mainly geographically distributed in the United States and China. Other blaNDM–1-carrying plasmids also included IncM2, IncN2, and IncHI1. Moreover, the overall picture of the conjugative and mobilizable blaNDM-positive plasmids in E. coli was described in our study. Our findings enhance our understanding of the genetic diversity and characteristics of blaNDM-positive plasmids in in E. coli.
Considering the Cellular Composition of Olfactory Ensheathing Cell Transplants for Spinal Cord Injury Repair: A Review of the Literature
Authors: Miah Mahjabeen , Ferretti Patrizia , Choi David
Published: November 2021

Olfactory ensheathing cells (OECs) are specialized glia cells of the olfactory system that support the continual regeneration of olfactory neurons throughout adulthood. Owing to their pro-regenerative properties, OECs have been transplanted in animal models of spinal cord injuries (SCI) and trialed in clinical studies on SCI patients. Although these studies have provided convincing evidence to support the continued development of OEC transplantation as a treatment option for the repair of SCI, discrepancies in the reported outcome has shown that OEC transplantation requires further improvement. Much of the variability in the reparative potential of OEC transplants is due to the variations in the cell composition of transplants between studies. As a result, the optimal cell preparation is currently a subject of debate. Here we review, the characterization as well as the effect of the cell composition of olfactory cell transplantation on therapeutic outcome in SCI. Firstly, we summarize and review the cell composition of olfactory cell preparations across the different species studied prior to transplantation. Since the purity of cells in olfactory transplants might affect the study outcome we also examine the effect of the proportions of OECs and the different cell types identified in the transplant on neuroregeneration. Finally, we consider the effect of the yield of cells on neuroregeneration by assessing the cell dose of transplants on therapeutic outcome.
Deep-Learning-Based Natural Language Processing of Serial Free-Text Radiological Reports for Predicting Rectal Cancer Patient Survival
Authors: Kim Sunkyu , Lee Choong-kun , Choi Yonghwa , Baek Eun Sil , Choi Jeong Eun , Lim Joon Seok , Kang Jaewoo , Shin Sang Joon
Published: November 2021

Most electronic medical records, such as free-text radiological reports, are unstructured; however, the methodological approaches to analyzing these accumulating unstructured records are limited. This article proposes a deep-transfer-learning-based natural language processing model that analyzes serial magnetic resonance imaging reports of rectal cancer patients and predicts their overall survival. To evaluate the model, a retrospective cohort study of 4,338 rectal cancer patients was conducted. The experimental results revealed that the proposed model utilizing pre-trained clinical linguistic knowledge could predict the overall survival of patients without any structured information and was superior to the carcinoembryonic antigen in predicting survival. The deep-transfer-learning model using free-text radiological reports can predict the survival of patients with rectal cancer, thereby increasing the utility of unstructured medical big data.
Triglyceride-Glucose Index Is Not Associated With Lung Cancer Risk: A Prospective Cohort Study in the UK Biobank
Authors: Wang Lijie , Si Shucheng , Li Jiqing , Li Yunxia , Chen Xiaolu , Xue Fuzhong , Ren Wangang
Published: November 2021

Background

The triglyceride-glucose (TyG) index is a practical substitute measure for insulin resistance (IR). The relationship between IR and lung cancer has been examined in previous studies; however, the findings have been controversial. In addition, previous studies had small sample sizes. Thus, we systematically examined the association between IR and lung cancer risk based on the UK Biobank with IR measured by the TyG index and further examined the interactions and joint effects for lung cancer.

Methods

A total of 324,334 individuals free from any type of cancer at recruitment from the UK Biobank prospective cohort were included. The participants were predominantly between 40 and 70 years old. After adjusting for relevant confounders, multivariable Cox regression models were constructed to examine the relationship between the TyG index and the risk of lung cancer. We also checked the interactions and joint effects using a polygenic risk score (PRS) for lung cancer.

Results

During a median follow-up of 9 years, 1,593 individuals were diagnosed with lung cancer. No association was found between the TyG index and lung cancer risk after multivariate Cox regression analysis adjusted for risk factors (hazard ratio: 0.91; 95% confidence interval: 0.64–1.18). No interaction or joint effects for genetic risk and the TyG index were observed.

Conclusion

The TyG index was not associated with the risk of lung cancer. Our results provide limited evidence that IR is not correlated with the risk of lung cancer.
Multimodal Imaging Technology Effectively Monitors HER2 Expression in Tumors Using Trastuzumab-Coupled Organic Nanoparticles in Patient-Derived Xenograft Mice Models
Authors: Wen Li , Xia Lei , Guo Xiaoyi , Huang Hai-Feng , Wang Feng , Yang Xian-teng , Yang Zhi , Zhu Hua
Published: November 2021

Trastuzumab is a monoclonal antibody targeting human epidermal growth factor 2 (HER2), which has been successfully used in the treatment of patients with breast cancer and gastric cancer; however, problems concerning its cardiotoxicity, drug resistance, and unpredictable efficacy still remain. Herein, we constructed novel organic dopamine–melanin nanoparticles (dMNs) as a carrier and then surface-loaded them with trastuzumab to construct a multifunctional nanoprobe named Her-PEG-dMNPs. We used micro-PET/CT and PET/MRI multimodality imaging to evaluate the retention effect of the nanoprobe in HER2 expression in gastric cancer patient-derived xenograft (PDX) mice models after labeling of the radionuclides 64Cu or 124I and MRI contrast agent Mn2+. The nanoprobes can specifically target the HER2-expressing SKOV-3 cells in vitro (3.61 ± 0.74 vs. 1.24 ± 0.43 for 2 h, P = 0.002). In vivo, micro-PET/CT and PET/MRI showed that the 124I-labeled nanoprobe had greater contrast and retention effect in PDX models than unloaded dMNPs as carrier (1.63 ± 0.07 vs. 0.90 ± 0.04 at 24 h, P = 0.002), a similarity found in 64Cu-labeled Her-PEG-dMNPs. Because 124I has a longer half-life and matches the pharmacokinetics of the nanoparticles, we focused on the further evaluation of 124I-Her-PEG-dMNPs. Furthermore, immunohistochemistry staining confirmed the overexpression of HER2 in the animal model. This study developed and validated novel HER2-specific multimodality imaging nanoprobes for quantifying HER2 expression in mice. Through the strong retention effect of the tumor site, it can be used for the promotion of monoclonal antibody treatment effect and process monitoring.