bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancement of Plasmonic Photovoltaics with Pyramidal Nanoparticles
Authors: Yassin Heba , El-Batawy Yasser , Soliman Ezzeldin
Published: November 2022

Light trapping as a result of embedding plasmonic Nano-Particles (NPs) into Photovoltaics (PVs) has been recently used to achieve better optical performance compared to conventional PVs. This light trapping technique enhances the efficiency of PVs by confining the incident light into hot-spot field regions around the NPs, which possess higher absorption, thus more enhancing of photocurrent. This research aims to study the impact of embedding metallic pyramidal-shaped NPs inside the PV’s active region for enhancing the efficiency of plasmonic silicon PVs. The optical properties of the pyramidal-shaped NPs in the visible and near-infrared spectrum have been investigated.The light absorption into silicon PV is significantly enhanced by embedding periodic arrays of pyramidal NPs in the cell comparedto the case of bare silicon PV. Furthermore, the effects of varying the pyramidal-shaped NPs dimensions on the absorption enhancement are studied. In addition, a sensitivity analysis has been performed, which helps in identifying the allowed fabrication tolerance for each geometrical dimension. The performance ofthe proposed pyramidal NP is compared with other frequently used shapes, such as cylinder, cone and hemisphere. Poisson’s and Carrier’s continuity equations are formulated and solved for the current density-voltage characteristics associated with embedded pyramidal NPs with different dimensions. The optimized array of pyramidal NPs provides an enhancement of 41% in the generated current density if compared to the bare silicon cell.
Dual-trigger improves oocyte maturation in patients with low oocyte maturation rate: a self-control study
Authors: Li Xiaolan , Li Qian , Cai Jiawei , Chang Yajie , Wang Yanfang , Liang Xiaoyan , Huang Rui
Published: November 2022

Background
For patients with low maturation rate, the efficacy of dual-trigger is still uncertain with few related data available. This large retrospective study focused on the effect of dual-trigger in oocyte maturation in patients with a history of low oocyte maturation rate.
Methods
A large retrospective self-controlled study was performed, which included 199 patients with a high proportion of immature oocyte (> 50%) in a previous hCG-only trigger cycle receiving a subsequent dual-trigger between January 2014 and June 2022. The primary outcome was the oocyte maturation rate, and the secondary outcomes were the number of oocytes retrieved, the normal fertilization rate, the high-quality embryos rate and the blastocyst formation rate. Linear regression analysis was applied to control the potential confounders.
Results
The results showed that no significant difference was observed in the number of follicles of > 14 mm and the E2 level on trigger day between the hCG-only and the dual-trigger cycle. Although the number of oocyte retrieval was comparable, higher rates of the oocyte maturation (64.96% vs. 39.40%), P < 0.001) and the normal fertilization (70.47% vs. 62.89%, P = 0.006) were associated with the dual-trigger group. In addition, a slightly higher rate of high-quality embryos (51.21% vs. 50.53%) and blastocyst formation (46.18% vs. 30%) were also observed in the dual-trigger group, although difference didn’t reach statistical significance. Furthermore, linear mixed model confirmed that the dual-trigger was positively associated with the oocyte maturation rate (β = 0.294, P < 0.001) after adjusting potential confounders, such as ovarian stimulation protocols.
Conclusions
Co-administration of GnRH-a and hCG for final oocyte maturation was suggested as an effective tool to improve oocyte maturation in patients with low maturation rate.
Discrete non standard formulation of PDE inverse problems
Authors: Moussata Cyr S. Ngamouyih , Haggar Mahamat Saleh Daoussa , Yindoula Deryl Nathan Bonazébi , Mampassi Benjamin
Published: November 2022

In this paper, we are interested in the computation of the unknown initial state for the simulation and prediction of PDE systems where the solution measures are partially known over a time interval. Such a problem is usually solved by an ill-posed optimal control problem. Based on an appropriate collocation approximation, we obtain a discrete inverse problem. To solve this problem, a non-standard discrete approach is used. This allows to obtain a transformation of the original problem into a well-posed ones based on the zero controllability of a discrete system. The desired control is then calculated as well as the discrete approximation of the initial state values.
Mathematics Subject Classification. 35K55; 35J60; 80A22.
The Product Structure and Algebraic Ricci Solitons of Three-dimensional Lorentzian Lie Groups
Authors: Wang Yanli
Published: November 2022

In this paper, we define a product structure on three-dimensional Lorentzian Lie groups. We compute canonical connections and Kobayashi-Nomizu connections and their curvature with this product structure. We classify algebraic Ricci solitons associ- ated to canonical connections and Kobayashi-Nomizu connections on three-dimensional Lorentzian Lie groups with this product structure.
Assembly line balancing and sensitivity analysis of a single-model stochastic sewing line using arena simulation modelling.
Authors: Hossain Arif , Muneer Khalid Ibn
Published: November 2022

Assembly line balancing is always a critical responsibility for manufacturers as it controls the efficiency and productivity of the assembly line. There are many techniques to solve line balancing problems, some of which are revealed in the literature review section, but computer-aided simulation modelling is prevalent among them. This study aims to analyze an assembly line balancing problem of stochastic nature using a discrete event simulation software (Arena) for the optimal solution and sensitivity analysis of the solution. The empirical study was carried out at Arunima Sportswear Limited garment factory, and a garment style (kid’s pants) with 21 operations was taken into account. First, the computer model was verified by line supervisors and validated by a statistical hypothesis test (t-test). Then, using the Arena OptQuest tool, an optimal solution to the model is achieved. Finally, a sensitivity analysis is performed by varying the values of some key factors (i.e. entities per arrival, process failure time, and operators’ absenteeism) to determine the level of uncertainty of the model.
SGNNRec: A Scalable Double-layer Attention-based Graph Neural Network Recommendation Model
Authors: He Jing , Tang Le , Tang Dan , Wang Ping , Cai Li
Published: November 2022

Due to the information from the multi-relationship graphs is difficult to aggregate, the graph neural network recommendation model focuses on single-relational graphs (e.g., the user-item rating bipartite graph and user-user social relationship graphs). However, existing graph neural network recommendation models have insufficient flexibility. The recommendation accuracy instead decreases when low-quality auxiliary information is aggregated in the recommendation model. This paper proposes a scalable graph neural network recommendation model named SGNNRec. SGNNRec fuse a variety of auxiliary information (e.g., user social information, item tag information and user-item interaction information) beside user-item rating as supplements to solve the problem of data sparsity. A tag cluster-based item-semantic graph method and an apriori algorithm-based user-item interaction graph method are proposed to realize the construction of graph relations. Furthermore, a double-layer attention network is designed to learn the influence of latent factors. Thus, the latent factors are to be optimized to obtain the best recommendation results. Empirical results on real-world datasets verify the effectiveness of our model. SGNNRec can reduce the influence of poor auxiliary information; moreover, with increasing the number of auxiliary information, the model accuracy improves.
Neutron Number Asymmetry in Proton Decay Momentum
Authors: Pachankis Yang
Published: November 2022

The authors have requested that this preprint be removed from Research Square.
Pestilence report of Helicoverpa armigera (Hübner) in apple fruit orchards in Northern Himalayan regions of India
Authors: Sharma Vani , Daroch Rakesh Kumar , Kasi Indra Kumar , Sharma PL , Kumar Pramod
Published: November 2022

Helicoverpa armigera Hübner (Lepidoptera: Noctuidae) an extremely destructive pest, causes large economic losses in numerous crops under favourable conditions. In the past few years, it has been seen by researchers and orchardists, feeding on apple fruits grown under high density plantation system under Himachal Pradesh Horticulture Development Project in North Himalayan regions ranging in 320.22’-330.12’N and 750.47’-790.04E with an extent of damage upto 10–15 per cent at various sites. Therefore, in order to determine its biotic potential on apple as a potential host, we studied the demographics of H. armigera on three apple varieties viz., Jeromine, Gale Gala and Red Velox at three fruit growth stages i.e. pea, walnut and mature stage with chickpea and chickpea based diet as control. The test insect completed its life cycle on apple and the duration of different developmental stages was almost equivalent to control, signifying it as potential pest in coming time. H. armigera was unable to survive beyond fifth instar in mature fruits stages, thereby indicating its preference for immature fruits. The population growth parameters were nearly identical; however, the highest values of finite rate of increase (λ) and intrinsic rate of increase (r) with minimum generation time (T) was recorded on insects reared on Gale Gala fruits at walnut stage (1.17, 0.15 and 36.59 days, respectively) which was found to be the most suitable host, while Red Velox was found to be the least preferable host at both pea and walnut stage. Overall, investigations on the biology of H. armigera revealed that apple is a preferred prospective host. If favourable environmental conditions exist, the insect may cause significant harm to high density apple fruit crops, necessitating its management in the future.
PENGARUH INFLASI, TINGKAT SUKU BUNGA, DAN NILAI TUKAR RUPIAH TERHADAP HARGA SAHAM PT BANK BTPN SYARIAH YANG TERDAFTAR DI BURSA EFEK INDONESIA (BEI) PERIODE 2019-2021
Authors: Oktaviani Marita Ayu , Sari Nadia Roosmalita
Published: November 2022

The purpose of this study is to find out the correlation of macroeconomic variables such as inflatin, interest rates, and the rupiah exchange rate with stock prices. Quantitative methods and purposive sampling techniques were adopted in this study. A total of 36 data as samples were taken using library and document methods. Multiple linear regression analysis was tested using software eviews 12. The results of the test and analysis both partially and simultaneously are: (1) the inflation variabel has no effect on stock prices, (2) the interest rate variabel has an effect on stock prices, (3) the exchange rate variable has an effect on stock prices, (4) variables of inflation, interest rates, and the rupiah exchange arte simultaneously affect stock prices.
A REVIEW ON OBTURATING MATERIALS FOR DECIDUOUS DENTITION
Authors:   Post Graduate Student, Department of Pediatric and Preventive Dentistry, DJ College Of Dental Sciences and Research Centre, Ghaziabad, Uttar Pradesh, India., Gupta Raman , Singh Jawa Deepti ,   Professor, Department of Pediatric And Preventive Dentistry, DJ College of Dental Sciences and Research Centre, Ghaziabad, Uttar Pradesh, India., Somani Rani ,   Professor and Head of the Department, Department of Pediatric and Preventive Dentistry, DJ College of Dental Sciences and Research Centre, Ghaziabad, Uttar Pradesh, India., Jaidka Shipra ,   Professor, Department of Pediatric And Preventive Dentistry, DJ College of Dental Sciences and Research Centre, Ghaziabad, Uttar Pradesh, India., Singla Ashish ,   Professor and Head of the Department, Department of Public Health Dentistry, DJ College of Dental Sciences and Research Centre, Ghaziabad, Uttar Pradesh, India., Sarkar Payal ,   Post Graduate Student, Department of Pediatric and Preventive Dentistry, DJ College Of Dental Sciences and Research Centre, Ghaziabad, Uttar Pradesh, India., Begum Monalisa ,   Post Graduate Student, Department of Pediatric and Preventive Dentistry, DJ College Of Dental Sciences and Research Centre, Ghaziabad, Uttar Pradesh, India., Santosh Anaswara ,   Post Graduate Student, Department of Pediatric and Preventive Dentistry, DJ College Of Dental Sciences and Research Centre, Ghaziabad, Uttar Pradesh, India.
Published: November 2022

In pulpally involved primary teeth, pulp therapy is necessary to preserve the primary teeth leaving the permanent tooth bud undisturbed. And for the successful pulp therapy, ideal obturating material that suit the specific properties of the teeth are necessary. Thus, a pediatric dentist should have a thorough knowledge about the various obturating materials so that the integrity of the dental arch can be maintained. Hence, this article aims to review the various obturating materials with their modifications as well as their advantages and disadvantages.
THE GAMIZED FORM OF TEACHING STUDENTS WITH DISABILITIES THROUGH THE USE AND UTILIZATION OF THE COMPUTER
Authors: Ioannis Novakos
Published: November 2022

Obviously, the gamified form of computer use and utilization in the teaching of students with disabilities has not been sufficiently investigated and studied regarding its contribution to their development and promotion. In this sense, the specific topic was chosen to examine to what extent this way and form of computer adoption and use affects, on the one hand, the processes and the result of the educational process and learning of these individuals/students, on the other hand, the their pedagogical and academic image and performance in all areas. Regarding the method of preparation of the specific work, the critical-interpretative review of the domestic and foreign language literature on this subject was selected and used. The results of the research demonstrate a significant trend and increase in the rates of computer use in the aforementioned form in the teaching and learning of people/students with disabilities, while regarding its contribution to the positive increase in their academic performance there is insufficient evidence from various scientific studies to support the above assumption.
CORRELATION BETWEEN INITIAL PRESSURE AND DURATION ON BUBBLE CPAP IN NEONATES WITH RESPIRATORY DISTRESS ADMITTED IN NEONATAL INTENSIVE CARE UNIT IN A TERTIARY CARE CENTRE
Authors:   Senior Resident, Velammal Medical College and Research Institute, Madurai., M.S Rubini , Kumar K. Senthil ,   Consultant Neonatologist, Department of Pediatrics, KMC hospitals, Trichy., Chelliah Suresh ,   Head of the department, Department of Pediatrics, KMC hospitals, Trichy., a Senguttuvan ,   Senior Consultant, Department of Pediatrics, KMC Hospitals, Trichy.
Published: November 2022

Background: Continuous Positive airway pressure (CPAP) is a non-invasive form of respiratory support, which is safe and effective in neonates with respiratory distress. The purpose of this study is to predict the length of stay on bubble CPAP in neonates by correlating the initial pressure and duration on it with respect to gestational age, birth weight and respiratory distress scores. Objective: To correlate the initial pressure and duration on bubble CPAP in neonates with respiratory distress thereby predicting the length of stay on it and analyzing the factors responsible for bubble CPAP failure. Materials and Methods: A prospective longitudinal study was conducted over a period of 2 years in neonates with respiratory distress requiring bubble CPAP. Applying Pearsoncoefficient, the initial pressure and duration on bubble CPAP was correlated with respect to different variables. The statistical analysis was performed using SPSS (Version 20.0). P value of <0.05 was considered as statistically significant. Results: Out of 246 neonates enrolled, 211(85.77%) neonates were successfully treated with bubble CPAP, with mean birth weight of 1.66 kg and mean duration of stay on bubble CPAP was 32.64 hours. Applying Pearson co- efficient on initial pressure and duration on bubble CPAP there was negative correlation, which was statistically significant. 35(14.23%) failed bubble CPAP. The predictors of failure were prematurity (51.43%), birth asphyxia (8.6%), age at initiation of bubble CPAP, sepsis (8.57%), Downes score and Silverman Anderson score of more than 6. Other maternal and neonatal variables did not influence the need of mechanical ventilation. Conclusion: The duration of stay on bubble CPAP and the initial pressure set are negatively correlated that is, higher the initial pressure there is significant reduction in duration on bubble CPAP thereby the length of stay can be predicted by initial pressure set.
MISMATCH STUDY OF META-LINE STRUCTURES RELATED TO DISPERSIVE PROPERTIES
Authors:   Research Laboratory in Electrical Engineering, Electronics and Energy (LR3E), National Institute of Science and Technology of Abeche, Chad., Mahamout Mahamat B. ,   Hubert Curien Laboratory (LabHC), Jean Monnet University of Saint-Etienne, France., D. Allassem ,   Research Laboratory in Electrical Engineering, Electronics and Energy (LR3E), National Institute of Science and Technology of Abeche, Chad.,   Hubert Curien Laboratory (LabHC), Jean Monnet University of Saint-Etienne, France., Arafat O.B. ,   Research Laboratory in Electrical Engineering, Electronics and Energy (LR3E), National Institute of Science and Technology of Abeche, Chad.,   Hubert Curien Laboratory (LabHC), Jean Monnet University of Saint-Etienne, France., Sauviac B. ,   Research Laboratory in Electrical Engineering, Electronics and Energy (LR3E), National Institute of Science and Technology of Abeche, Chad.
Published: November 2022

The study focuses on coplanar metamaterial lines and resonators and the possibility to increase their performances. To achieve our goal, we studied these structures accesses for a better adaptation. This study allowed us to optimize the accesses of meta-lines components. We thus obtain a possibility of cells which it is necessary to decrease the losses in meta-lines structures.
A DYNAMIC BANDWIDTH ALLOCATION SYSTEM IN XG-PONS BASED ON STATISTICAL ESTIMATION OF BUFFER INPUTS AND OUTPUTS
Authors:   Ecole Doctorale Polytechnique de lINP-HB Yamoussoukro, Cote dIvoire., Akanza Konan Ricky NDRI ,   Laboratoire de Recherche en Informatique et Telecommunication (LARIT)., Bi Tra GOORE ,   Ecole Doctorale Polytechnique de lINP-HB Yamoussoukro, Cote dIvoire.,   Laboratoire de Recherche en Informatique et Telecommunication (LARIT)., Jean Edgard GNIMASSOUN ,   Ecole Doctorale Polytechnique de lINP-HB Yamoussoukro, Cote dIvoire.,   Laboratoire de Recherche en Informatique et Telecommunication (LARIT)., Yve TIECOURA ,   Ecole Doctorale Polytechnique de lINP-HB Yamoussoukro, Cote dIvoire.,   Laboratoire de Recherche en Informatique et Telecommunication (LARIT).
Published: November 2022

The exchanges in the New Generation Optical Access Network (NG-PON), are mainly based on the bandwidth request by the Optical Network Units (ONU) and its granting by the Optical Line Termination (OLT). This process (request-grant) not being synchronized, will create in the ONU buffer a long delay and the loss of sensitive packets. Many authors, from signaling to prediction, have proposed models to control these parameters, however only those based on prediction reduce the delay in the queues but also waste bandwidth by over- or under-allocating. Our goal is to propose a model that accurately allocates bandwidth to ONU while minimizing their queue delay. As such, we propose a Statistical Queue Estimation model based on ONU Buffer Inputs and Outputs (ESTEST). In its execution ESTEST memorizes the ONU bandwidth requirements and the bandwidth used to transmit their data in the ith upstream frames. With these two parameters (requirements and bandwidth used), our algorithm computes the traffic intensity (ðœŒ) and predicts the queue size of the ONU. On 100 observations we compute the mean and standard deviation of the ðœŒth values and with the reduced centered normal distribution, find the confidence interval of size estimation.
CARACTERISATION DES PRATIQUES PHYTOSANITAIRES ET DES PESTICIDES CHIMIQUES UTILISES PAR LES PRODUCTEURS MARAICHERS AUTOUR DE DEUX ECOSYSTEMES AQUATIQUES CLASSES SITES RAMSAR AU NIGER : LE LAC GUIDIMOUNI ET LA MARE DE TABALAK
Authors:   Universite Abdou Moumouni de Niamey, Ecole Normale Superieure, Departement des SciencesDe La Vie Et De La Terre, PB 10963, Niamey, Niger., Tawaye Abdoullatif Youchaou , Bassirou Alhou ,   Universite Abdou Moumouni de Niamey, Ecole Normale Superieure, Departement des SciencesDe La Vie Et De La Terre, PB 10963, Niamey, Niger.
Published: November 2022

To protect crops and secure yields, market gardeners are increasingly resorting to a range of chemical pesticides, only some of these products are known to have harmful effects. In order to assess the potential danger of pesticides used by market gardeners for two aquatic ecosystems, a survey was conducted among 200 market gardeners around Lake Guidimouni and the Tabalak pond, two Ramsar sites in Niger. An inventory of pesticides was carried out, the use of these products was highlighted and an index was calculated to determine their potential danger to these ecosystems. All the producers questioned use chemical pesticides 69% and 77% of the producers have no training in the application of phytosanitary products 77% and 89% treat between 1 and more than 3 times a week, 1% follow the packaging instructions to apply the dosage several practices that can lead to water contamination were noted. The indices of the active ingredients, taken individually, show that the use of these molecules can constitute potential dangers for aquatic ecosystems: 60 and 65.11% have very high indices 20 and 9.30% have average indices at Guidimouni and Tabalak respectively. A study should be conducted to assess the exposure and impacts of the latter on these ecosystems.
Passando a boiada: A pandemia da Covid-19, a desestruturação das políticas ambientais e o neoliberalismo de austeridade
Authors: Freitas Raíssa Dias de , Clark Giovani , Corrêa Leonardo Alves
Published: November 2022

O trabalho apresenta um estudo sobre a desestruturação das políticas ambientais brasileiras, especialmente observáveis durante a pandemia causada pelo novo coronavírus, e seu enquadramento nas políticas do neoliberalismo de austeridade. Inicialmente, serão abordados aspectos relativos ao direito ao meio ambiente ecologicamente equilibrado, consagrado no texto da Constituição da República de 1988 e em outros instrumentos jurídicos. Na sequência, apresentam-se as medidas de desestruturação das políticas ambientais instituídas pela União no período da pandemia da Covid-19, bem como suas consequências sobre os indicadores ambientais brasileiros. Ato contínuo, os argumentos neoliberais de austeridade, que justificariam a adoção dessas medidas pelo Estado brasileiro, serão apresentados, de modo a demonstrar sua inadequação aos ditames consagrados pela Constituição da República de 1988. Para tanto, a investigação dá-se por meio da análise da legislação, da doutrina e de dados constantes em sites institucionais e plataformas do Estado, adotando-se o método analítico substancial do professor Washington Peluso Albino de Souza e como referencial teórico a construção sobre neoliberalismo de austeridade apresentada pelos professores Giovani Clark, Leonardo Alves Corrêa e Samuel Pontes do Nascimento.
A evolução da prestação de serviços públicos na sociedade da informação
Authors: Malheiro Emerson Penha , Romão Renato Evangelista
Published: November 2022

O presente artigo tem por objetivo analisar como a evolução da prestação dos serviços públicos tem impactado significativamente na vida dos cidadãos nas mais diversas formas, buscando perceber como esta percepção passa pela construção da própria democracia e da democracia digital, que ampliou as formas de como a sociedade interage com a tecnologia no Estado Democrático e Social de Direito. Abordamos, assim, como a função social do Estado evoluiu nas perspectivas mais filosóficas até a chegada das necessidades digitais que nos circundam diariamente. Por fim, verificamos como o Estado tem ampliado o uso de tecnologias a serviço da sociedade e quais são, ainda, as necessidades e desafios impostos a ele para que a democracia participativa dos cidadãos prevaleça.
Reservas particulares e a função social da propriedade
Authors: Vosgerau Gusi Carol , Bueno Wandscheer Clarissa
Published: November 2022

O presente artigo investiga a aplicabilidade do princípio da função social da propriedade, garantido e reforçado pela Constituição Brasileira de 1988, ante a criação de unidades de conservação, de forma mais específica, de Reservas Particulares do Patrimônio Natural (RPPN). Por meio de uma metodologia de natureza básica, de caráter objetivo descritivo e utilizando-se dos procedimentos bibliográfico e documental, o estudo relata brevemente a evolução do princípio, a mudança na mentalidade sobre a propriedade privada, assim como aborda a importância da proteção ambiental, e sugere o conceito de função socioambiental como uma combinação mais inteligente. Tem como objetivo responder aos questionamentos: A criação de Unidades de Conservação (UC) consiste em um ato contrário ao princípio da função social da propriedade? E, se a instituição de uma UC for motivada pela livre-iniciativa do proprietário da terra, como no caso da RPPN, a função social da propriedade continuará sendo atendida? Como resultado, concluiu-se que, a criação de uma UC e o princípio constitucional abordado não são mutuamente excludentes e, mesmo no caso da RPPN, o princípio continuará sendo atendido.
Europeanization of Environmental Law of the European Union Member States
Authors: Yakoviyk Ivan , Anisimova Hanna , Tragniuk Olesia
Published: November 2022

Topicality. The topicality of the issue presented in the article is due to the insufficiency of research on the Environmental Law Europeanization in domestic legal science.
The purpose of the article. The purpose of the article is to study the essence of the concept of “law Europeanization” and the peculiarities of its implementation in the field of Environmental Law of EU member states and candidate states.
Research methods. The Europeanization concept arose and developed as a result of changes occurred within the theory of integration itself. The article deals with the influence of the process of deepening of the integration and expansion of the European Union on the obligations of the member states regarding the protection of the environment and climate.It is observed that the construction and functioning of the EU legal order is a decisive factor of integration, which is viewed as a project of building a single market, complemented by the range of policies implementation, in particular in the field of environmental and climate protection.
Results. The concept of Environmental Law Europeanization was analyzed, and the way how the legal systems of the EU member states contribute to the development of the European Union Environmental Law, which is supranational by its legal nature, was examined.It is emphasized that the Europeanization of law cannot be addressed as a homogeneous process, nor as a process that leads to the same result in each of the member states.Despite the obvious dominance of international law and globalization as factors determining the national law reform, it can be argued that the peculiarities of legal regulation of relations in the field of environmental and climate protection are caused by the consequences of “soft” or indirect Europeanization. In many cases, the rules of the EU legal order, which are incompatible with national rules, create pressure on national governments, prompting them to adapt national environmental legislation to European environmental legal standards. Attention is drawn to the fact that within the framework of the process of European integration, the process of de-Europeanization can occur to a certain extent and for various reasons.
The significance of the results. The conclusions obtained as a result of the research will contribute to the awareness of the phenomenon of Europeanization of the EU member states and candidate states national law, in particular such a component as Environmental Law, its directions and forms, and may be useful in the process of domestic environmental legislation to the European Union environmental legislation adaptation.
Pengaruh Fasilitas Kamar dan Perceived Value pada Minat Beli di Hotel
Authors:   Program Studi D3 Perhotelan, Sekolah Tinggi Pariwisata Bogor Jl. Curug Mekar No. 17, Yasmin. Kota Bogor, Jawa Barat 16113, Indonesia, Irfan Muhammad , Rahmaniyah Utami Nisa ,   Program Studi D3 Perhotelan, Sekolah Tinggi Pariwisata Bogor Jl. Curug Mekar No. 17, Yasmin. Kota Bogor, Jawa Barat 16113, Indonesia
Published: November 2022

The purpose of this study is to determine the dominant factor of room facilities in negative reviews and to determine consumer buying interest at the Horison Ultima hotel. This study uses a quantitative descriptive research method, which uses an application that is calculated using the T test. The sample in this study was taken by random sampling and involved 100 respondents. The results showed that all variables received good ratings from the respondents. Multiple Regression Test shows that Room Facilities and Perceived Value variables have a significant simultaneous (together) effect on Purchase Interest at Horison Ultima Hotel Bekasi.
Metode Penyimpanan Bahan Baku Pastry & Bakery yang Meningkatkan Kualitas Layanan Hotel
Authors:   Sekolah Tinggi Pariwisata Bogor, Jl. Curug Mekar No. 17, Yasmin. Kota Bogor, Jawa Barat 16113, Indonesia, Utami Nisa Rahmaniyah , Ishak Riani Prihatini ,   Sekolah Tinggi Pariwisata Bogor, Jl. Curug Mekar No. 17, Yasmin. Kota Bogor, Jawa Barat 16113, Indonesia, Fiqhan Faqih Muhammad Ibnu ,   Sekolah Tinggi Pariwisata Bogor, Jl. Curug Mekar No. 17, Yasmin. Kota Bogor, Jawa Barat 16113, Indonesia
Published: November 2022

The department of food and beverage products is in charge of a section called pastry & bakery which provides a variety of cakes, breads and snacks that can be sold or enjoyed by guests. To maintain the quality of pastry & bakery products, one must do and pay attention to the storage of raw materials, one way is to do a good and correct storage method. This study aims to find out how the method used by R Hotel in an effort to maintain the quality of raw materials in the pastry & bakery section by describing what obstacles are experienced by the pastry & bakery section in storing raw materials. This study uses a qualitative method. The process of storing pastry & bakery raw materials at R Hotel uses predetermined standards. Like always checking the raw materials in the storage area, the placement of raw materials also needs to be considered in the storage process and implementing the FIFO (First In First Out) method.
Spatially coherent statistical simulation of widespread flooding events under climate change
Authors: Griffin Adam , Kay Alison , Stewart Elizabeth , Sayers Paul
Published: November 2022

Simulating rare widespread hydrological events can be difficult even with the use of modelled data such as the UKCP18 12 km regional climate projections. To generate larger event sets for application in catastrophe modelling, two statistical approaches are highlighted and applied to widespread GB-generated flooding events using a grid-based hydrological model and UKCP18 regional projections. An Empirical Copula method was applied on a national scale, generating over 600,000 events across two time-slices (1980–2010 and 2050–2080). This was compared to model-generated events and showed good matching across time-slices and ensemble members, although lacked some ability to describe the least-rare events. The Empirical Copula was also compared to an implementation of a conditional exceedance model. This model was much more computationally intensive so was restricted to Northwest England but offered the ability to be tuned more finely through choices of marginal distributions. Analysing over 11,000 events, it also matched well with the Empirical Copula and model-generated events but under-represented the smallest events. Both approaches require a broad dataset to draw from but showed reasonable efficacy. For simple statistics, the Empirical Copula shows the potential to be a powerful tool in exploring spatial structure over large regions or at a fine spatial resolution.
An evaluation of groundwater quality and its suitability for drinking and irrigation uses under the GIS framework
Authors: Raheja Hemant , Goel Arun , Pal Mahesh
Published: November 2022

This study reported the results of groundwater quality for drinking and irrigation purposes in Kurukshetra district, Haryana, India. Twelve parameters, namely pH, TDS, TH, sodium (Na+), magnesium (Mg2+), calcium (Ca2+), potassium (K+), chloride (Cl−), sulfate (SO42−), bicarbonate (HCO3−), nitrate (NO3−), and fluoride (F−) were evaluated and the Water Quality Index (WQI) was calculated. Based on the WQI, 31.57% and 68.43% of samples fall in excellent and good drinking water quality. The sodium adsorption ratio (SAR: 5.75–33.8), magnesium hazard ratio (MHR: 0.21–0.75), percent sodium (%Na: 31.34–72.84), residual sodium carbonate (RSC: 139–770), potential salinity (PS: 18.5–90), and Kelley Ratio (KR: 0.9–3.13) were calculated. The SAR, %Na, MHR, and KR indicated that most of the groundwater is suitable for irrigation. In addition, the inverse distance weighted (IDW) interpolation method was also employed to determine the spatial distribution of groundwater quality in the form of maps using ArcGIS software. The Pearson correlation matrix has been calculated to analyze the relationship between the water quality parameters. Gibbs plots have shown that evaporation and rock weathering are primary processes responsible for affecting the hydrochemistry of groundwater. Piper plots suggested that maximum groundwater samples are (HCO3−–Na+), (Na+), and (HCO3−) types.
Parameter evaluation of a nonlinear Muskingum model using a constrained self-adaptive differential evolution algorithm
Authors: Mohaideen Abdul Kadhar Kattuva , Natarajan Narayanan , Vasudevan Mangottiri , Gurusamy Saravanakumar
Published: November 2022

The precise evaluation of the Muskingum model (MM) parameters is quite critical for routing flood waves for achieving flood control in open channels. The MM is one of the popular techniques adopted for flood routing. Estimation of the MM parameters so as to provide the best fit for the observed and computed flow values is a global optimization problem. Several optimization techniques have been adopted in the past to serve this purpose, but efficient optimization algorithms are needed to overcome the local optima issues and improvement of accuracy. In this paper, the efficiency of three optimization algorithms, namely Jaya, Covariance Matrix Adaption-Evolution Strategy (CMAES) and self-adaptive differential evolution (SaDE), has been assessed in the evaluation of the Muskingum parameters. The sum of the square deviation of the observed outflow and computed outflow (SSQ) is considered an objective in this MM optimization problem. Also, a constraint is proposed in this paper to help the optimization algorithms in finding the optimal global solutions. The simulation results show that the sum of the square deviation of the observed outflow and computed outflow (SSQ) was the least for SaDE, followed by CMAES.

HIGHLIGHTS Precise evaluation of Muskingum model (MM) parameters is quite critical for routing flood waves. Efficient optimization algorithms are needed to overcome local optima issues in the estimation of the Muskingum parameters. Jaya, Covariance Matrix Adaption-Evolution Strategy (CMAES) and self-adaptive differential evolution (SaDE) have been assessed. SaDE shows the best performance followed by CMAES.
Strong Binding of Phytochemicals to the Catalytic Domain of Tyrosine Hydroxylase
as a Trojan Horse Decreases Dopamine in Dopaminergic Cells: Pharmaceutical
Considerations in Schizophrenia and Parkinson’s Disease
Authors: Tavakol Shima , Hoveizi Elham , Tavakol Hani , Almasi Amin , Soleimani Mansoureh , Rabiee Motmaen Shadi , Azedi Fereshteh , Joghataei Mohammad Taghi
Published: November 2022

Background:

Imbalances in dopamine levels result in neurological and psychological disorders such
as elevated dopamine in Parkinson’s disease.

Objective:

Despite a considerable number of advertisements claiming Aloe-vera’s effectiveness in PD treatment,
it has hidden long-term disadvantages for healthy people and PD patients.

Methods:

In the present investigation, the impacts of Aloe-vera on dopaminergic cells were evaluated.

Results:

The results indicated that the focal adhesion kinase (FAK) enhancement was in line with the Bax/Bcl2
ratio decrement, reactive oxygen specious (ROS) production, and nonsignificant alteration in the sub-G1phase
of the cell cycle. It led to glial cell-derived neurotrophic factor (GDNF) upregulation but did not significantly
change the BDNF level involved in depression and motor impairment recovery. These events apparently resulted
in the enhancement in dopaminergic cell viability and neurite length and attenuated PI+ cells. However, it
also induced neuronal nitric oxide synthase (nNOS) overexpression and nitric oxide (NO) and lactate dehydrogenase
(LDH) production. Notably, docking results of the catalytic domain in tyrosine hydroxylase (TH) with
the Aloe-vera constituents showed strong binding of most Aloe-vera constituents with the catalytic domain of
TH, even stronger than L-tyrosine as an original substrate. Following the docking results, Aloe-vera downregulated
TH protein and attenuated dopamine.

Conclusion:

It can be hypothesized that Aloe-vera improves PD symptoms through enhancement in antiapoptotic
markers and neurotrophic factors, while it suppresses TH and dopamine in the form of a Trojan horse,
later resulting in the future deterioration of the disease symptoms. The results provide cues to pharmaceutical
companies to use the active components of Aloe-vera as putative agents in neurological and psychiatric disorders
and diseases to decrease dopamine in patients with enhanced dopamine levels.
Recent Developments and Anticancer Therapeutics of Paclitaxel: An Update
Authors: Thiruvengadam Muthu , Ahmed Khalil Anees , Rauf Abdur , Alhumaydhi Fahad A. , Aljohani Abdullah S.M. , Javed Muhammad Sameem , Khan Muhammad Arslan , Khan Imtiaz Ali , El-Esawi Mohamed A. , Bawazeer Sami , Bouyahya Abdelhakim , Rebezov Maksim , Shariati Mohammad Ali
Published: November 2022

Plants are a source of diverse classes of secondary metabolites with anticancer properties. Paclitaxel (Taxol) is an anticancer drug isolated from various Taxus species and is used as a chemotherapeutic agent against various cancers. The biosynthesis of paclitaxel is a complex pathway, making its total chemical synthesis commercially non-viable; hence, alternative novel sources - like plant cell culture and heterologous expression systems, are being investigated to overcome this issue. Advancements in the field of genetic engineering, microbial fermentation engineering, and recombinant techniques have significantly increased the achievable yields of paclitaxel. Indeed, paclitaxel selectively targets microtubules and causes cell cycle arrest in the G2/M phase, inducing a cytotoxic effect in a concentration and time-dependent manner. Innovative drug delivery formulations, like the development of albumin-bound nanoparticles, nano-emulsions, nano-suspensions, liposomes, and polymeric micelles, have been applied to enhance the delivery of paclitaxel to tumor cells. This review focuses on the production, biosynthesis, mechanism of action, and anticancer effects of paclitaxel.
Doped Carbon Dots as Promising Fluorescent Nanosensors: Synthesis, Characterization,
and Recent Applications
Authors: Magdy Galal , Elmansi Heba , Belal Fathalla , El-Deen Asmaa Kamal
Published: November 2022

Carbon dots (CDs) have recently attracted attention as a new class of photoluminescent materials
with promising optical, chemical, and electrical properties. They have been proposed for various applications,
such as pharmaceutical sensing, biomarker detection, and cellular bioimaging, by virtue of their economical
synthesis, cheap starting materials, water-solubility, excellent chemical stability, good biocompatibility, and
low toxicity. Hetero-atom doping is a reliable and adaptable strategy for enhancing the photoluminescence,
electrical, and structural characteristics of CDs. Herein, we present an update on heteroatom-doped CDs.
Various modern synthetic routes are highlighted, ranging from synthetic processes to doping components. In
addition, the optical and biological properties and the possible applications of heteroatom-doped CDs are
discussed. This review will provide an overview of recent advances in doped CDs and their expected future
perspectives.
Hydrazonoyl Halides as Precursors for Synthesis of Bioactive Heterocyclic Compounds via Reaction with Aryl- and Hetaryl-Amine
Authors: Farghaly Thoraya A. , Alsaedi Amani M.R. , Qurban Jihan , Nayl AbdElAziz A. , Zaki Yasser H. , Gomha Sobhi M.
Published: November 2022

A literature survey revealed that a great deal of interest had been focused on the synthesis of functionalized heterocyclic compounds due to their wide range of biological activities such as antimicrobial, antitumor, anti-inflammatory, antiviral, antibiotic, antidepressant, antimalarial, antifungal and antihypertensive. Moreover, it is used as pharmaceuticals, agrochemicals and veterinary products. They are also found in sensitizers, developers, antioxidants, as corrosion inhibitors, as copolymers, and dyes. On the other hand, hydrazonoyl halides are interesting synthons for valuable bioactive heterocyclic compounds. Reaction of hydrazonoyl halides with various types of aryl-amines and hetaryl-amines generated a huge number of different heterocyclic systems. In this review, we collected all reactions of hydrazonoyl halides with aryl- and hetaryl amines and classified them according to the type of the amines up to the end of 2021. Most reaction types have been successfully applied and used in the production of biologically active compounds.
The Diagnostic and Prognostic Value of Plasma Circulating
CircNUP98 for Nasopharyngeal Carcinoma
Authors: Zhang Bin , Xu Bohuai , Yu Lujie , Pei Yingying , He Yong
Published: November 2022

Background:

Our preliminary sequencing analysis revealed increased expression
levels of circNUP98 in nasopharyngeal carcinoma (NPC). This study was
therefore carried out to explore the role of circNUP98 in NPC.

Methods:

The present study enrolled 56 patients with NPC, 44 patients with cervical
lymphadenitis (CL), 50 patients with nose bleeding (NB), 50 patients with chronic sinusitis
(CS), 50 patients with lymph node tuberculosis (LNT), and 50 healthy controls
(Control). Plasma samples were obtained from all patients and the controls. In addition,
NPC and paired non-tumor tissue samples were collected from the 56 NPC patients.
The expression of circNUP98 in both tissue and plasma samples was determined
by RT-qPCR. The 56 NPC patients were followed up for 5 years to analyze the
associations between plasma expression of circNUP98 and the survival of patients.
The diagnostic value of circNUP98 for NPC was analyzed through ROC curve analysis.

Results:

The plasma expression levels of circNUP98 were only increased in NPC, but
not in CL, NB, CS and LNT groups compared to that in the Control group. In addition,
increased expression levels of circNUP98 were observed in NPC tissues compared to
that in non-tumor tissues. Plasma circNUP98 was closely correlated with circNUP98 in
NPC tissues, but not circNUP98 in non-tumor tissues. With plasma circNUP98 as a
biomarker, NPC patients were separated from CL, NB, CS, LNT, and the Control
groups. The Plasma expression of circNUP98 was found to be positively correlated
with the poor survival of patients. Moreover, plasma circNUP98 was only closely
associated with tumor metastasis, but not tumor size.

Conclusion:

The expression of circNUP98 in plasma may be used to diagnose NPC
and predict patients’ survival.
The Structure-property Relationships of GPCR-targeted Drugs
Approved between 2011 and 2021
Authors: Choi Kihang
Published: November 2022

Background:

G-protein-coupled receptors (GPCRs) are the largest family of
membrane receptors and the most intensively studied drug targets. Given the physiological
importance of signal transduction by GPCRs and the recent progress in the structure
determination of membrane proteins, the development of GPCR antagonists and agonists
is expected to continue to be a major area of medicinal chemistry research.

Methods:

The structure-property relationship illustrates how the modification of the
chemical structure influences the absorption, distribution, metabolism, excretion, and
other related properties of drug compounds. Understanding the structure-property relationships
of clinically approved GPCR-targeted drugs and their analogues could provide
useful information on the lead-to-candidate optimization strategies.

Results:

Among more than 50 GPCR antagonists and agonists approved in the last decade,
the structure-property relationships of 17 drugs are compiled from medicinal chemistry
literature, in which detailed pharmacokinetic and toxicological properties are disclosed
not only for the final drug candidate but also for key analogues generated during
the lead optimization campaign.

Conclusion:

The structure-property relationships hereby summarized demonstrate how
in vitro and in vivo properties of the membrane protein-targeted ligands could be effectively
optimized, in many cases, without requiring a significant change in the molecular
size. This information is expected to provide valuable insights to expedite new GPCR-targeted
drug development.
MRI Study on the Relationship Between Nerve and Blood Vessel in Unilateral
Angiogenic Trigeminal Neuralgia
Authors: Miao Xinglu , Yu Mingsheng , Wang Zengguang
Published: November 2022

Background:

Trigeminal neuralgia (TN) is a common cranial nerve disease.

Objective:

To investigate the relationship between the trigeminal nerve and the responsible blood vessel
in patients with unilateral vascular trigeminal neuralgia (VTN).

Methods:

Thirty patients with unilateral VTN were confirmed by microvascular decompression.

Results:

Among the 30 patients, the responsible blood vessels were present in 30 cases on the affected
side and 17 cases on the uninfected side (1). The location of the intersection of the trigeminal nerve
and the responsible blood vessel: the affected side is located 2/5 behind the trigeminal nerve cisternal
segment; the healthy side is located 3/5 anterior to the cisternal segment (2). Symptomatic vessels were
located within the cistern between the origin and 2/5ths of the cistern length, and non-symptomatic
vessels were located beyond the 2/5ths location (3). Direction of intersection: on the affected side, the
responsible vessel was located inside and above the trigeminal nerve in 27 cases, (27/30, 90%), and
outside and below the trigeminal nerve in 3 cases (3/30, 10%). On the unaffected side, the responsible
vessel was located inside and above the nerve in 16 cases (16/17, 94%) and outside and below the
nerve in 1 case (1/17, 5.8%) (4). Intersection form: 3 cases (3/30, 10%) on the affected side, the responsible
blood vessel contacted the trigeminal nerve, in 26 cases (26/30, 86%) the responsible blood
vessel compressed the trigeminal nerve, and in 1 case (1/30, 5%) the responsible blood vessel caused
the trigeminal nerve to be twisted; 8 cases (8/17, 47%) of the contralateral side contacted the trigeminal
nerve with the responsible blood vessel, and in 9 cases (9/17, 53%) the responsible blood vessel compressed
the trigeminal nerve.

Conclusion:

Patients with unilateral VTN have differences in the location and form of the intersection
of the trigeminal nerve and the responsible vessel on the affected side and the contralateral side.