bluuebunny/crossref_metadata_2025 huggingface dataset:
Çanakkale Özbek Ovasındaki İşletmelerde Yeterli ve Kısıtlı Su Koşullarında Optimum Bitki Deseninin Belirlenmesi
Authors: AKYÜZ Seher , YILDIRIM Murat
Published: December 2022

Kurak dönemlerde tarımsal amaçlı kullanılan suyun kıt bir kaynak olması nedeniyle, tarım sektöründe suyun teknik koşullara uygun bir şekilde verilmesi gerekliliği günümüzde büyük bir önem kazanmıştır. Bu çalışmada, suyun yeterli ve kıt olması durumunda doğrusal programlamadan yararlanarak, bir sulama alanında optimum bitki desenini belirlemek ve sonuçta üreticinin kar’ını yükseltmeyi amaçlamaktadır.
Bölge olarak Çanakkale’nin Özbek ovası ele alınmıştır. Özbek ovasında toplamda 12018 dekar alanı tarımsal üretim gerçekleştirilmektedir. Bu alan içerisinde alanı temsil eden ve yoğunlu en fazla olan iki farklı ölçekteki işletme ele alınmıştır. Farklı iklim koşullarında; kurak, normal ve yağışlı yıllara göre ve bitki su ihtiyacının S1(%100), S2(%80), S3(%50) karşılandığı sulama konularına göre doğrusal programlama modeli (WinQSB) kullanılarak optimum bitki deseni belirlenmiştir. Farklı iklim ve sulama suyu miktarları ve elde edilebilecek verim değerlerine göre üreticinin elde edebileceği net gelir belirlenmeye çalışılmıştır.
Carpet Art As A Source of Inspiration in Urban Landscape Design
Authors: ERDOĞAN Reyhan , DEMİRHAN Dicle Nur , OLGUN Rifat
Published: December 2022

One of the sources of inspiration used to increase the aesthetic value of a design product is the traditional arts owned by that culture. When the Turkish traditional art is examined, it is seen that the oldest art is the art of carpet. For this reason, Turkish carpet art was used as a means of inspiration in urban landscape designs. The aim of the research is to emphasize the importance of using local and cultural values as inspiration in urban landscape designs and to provide urban landscape design proposals for the preservation and transfer of these values to future generations. In this context, "Dösemealti" carpets belonging to the Antalya region, which have a significant place in terms of traditional carpet art in Turkey, are considered as a source of inspiration in urban landscape design. Thus, the characteristic features of Dösemealti carpets in traditional Turkish carpets are reflected in urban landscape designs.
Ezine (Çanakkale) Yöresinde Granitik Kayaçlar Üzerinde Oluşmuş İki Toprak Profilinin Genesisi ve Bazı Özellikleri
Authors: TUNÇ Uğur , EKİNCİ Hüseyin
Published: December 2022

Çanakkale İli Ezine ilçesi Kemallı köyü (P1) ve Akçakeçili köyünde (P2) yürütülen bu çalışmada, granitik kayaçlar üzerinde farklı topoğrafilk koşullarda oluşmuş iki toprak profili incelenmiştir. Ezine ilçesinin yıllık ortalama yağış miktarı 586 mm, yıllık sıcaklık ortalaması 15.70C dir..İncelenen iki profilin arazide morfolojik tanımlamaları yapılmış ve horizon esasına göre toprak örnekleri alınmıştır. Bu örneklerde bazı fiziksel ve kimyasal analizlerin yanında, XRD (X Ray Difraksiyon), SEM (Taramalı Elektron Mikroskobu) ve EDS - EDX (enerji Dağılımlı X-ışını Spektroskopisi) ve major oksit gibi analizler de yapılmıştır. Profillere ait horizon örneklerinde CIA (kimyasal ayrışma indeksi), PIA (plajioklas alterasyon indeksi) ve SİO2/Al2O3 gibi bazı ayrışma oranları hesaplanmıştır. Profil 1 Ap -A2- Bw-C ve profil 2 ise Oe-A-Bt-C horizonlarına sahiptir. İşlemeli tarım yapılan arazide yer alan P1 de kum- tınlı kum, ormanlık alanda yer alan profil 2 ise yüzeyde tınlı kum ve yüzey altında kumlu kil tın bünye sınıfındadır. P1 de bir kambik horizon P2 de bir argillik horizon oluşumu belirlenmiştir. Katyon değişim kapasitesi (KDK) P1’in kambik horizonunda 18 cmolkg-1 iken P2 nin argillik horizonunda 22.78 cmolkg-1 olarak belirlenmiştir. Her iki profilin de CIA ve PIA ayrışma indeksleri 50-60 arasında oldukça düşük bulunmuştur. Ancak P2 nin Bt horizonunda topoğrafik koşullara bağlı olarak PIA 60 ve CIA ise 57 olarak diğer tüm horizonlardan yüksek bulunmuştur. Her iki profilde de kuvars mineralinin yanında albit, ortoklas ve anortit gibi feldspatların yüksek oranda bulunması ayrışmanın düşük olduğunu göstermektedir. Toprak profilleri toprak taksonomisine göre sırasıyla P1 Lithic Haploxerepts, profil 2 ise Lithic Mollic Haploxeralfs; WRB sınıflamasına göre profil 1 P1 Endoleptic Cambisols, profil 2 ise Leptic Luvisols olarak sınıflandırılmıştır. Çalışma sonuçları benzer iklim koşulları altında, farklı topoğrafik koşulların granitik kayaçlar üzerinde oluşmuş iki toprak profilinde, profil gelişimini, fiziko-kimyasal özellikleri ve toprak sınıflandırmasını etkilediğini göstermiştir.
Elementi antičkih pojasnih
garni tura, konjske i druge vojne opreme iz muzejskih zbirki u Bosni i
Hercegovini (izbor nalaza)
Authors: Busuladžić Adnan
Published: December 2022

U Zemaljskome muzeju Bosne i Hercegovine, u Franjevačkome samostanu u Tolisi, zatim muzeju u Doboju, Muzeju Hercegovine u Mostaru kao i drugim muzejskim ustanovama, između mnogobrojnih nalaza, čuva se i određeni broj predmeta koji se mogu uvrstiti u širu skupinu predmeta koji pripadaju pojasnim garniturama, okovima, falerama, dugmadima, pojasnim jezičcima, privjescima, vrhu korice mača te dijelovima kacige. Ovi predmeti u najvećoj mjeri pripadaju dijelu vojničke opreme za remenje, pojaseve, zatim kao dio konjske opreme, cipela, oklopa i drugih dijelova. Navedeni predmeti služili su u praktične svrhe, ali i kao dio dekorativnoga sadržaja. U nekim slučajevima pojedine forme su u odnosu na interpretaciju mogle imati i apotropejsko i profilaktičko značenje. S obzirom na široki spektar predmeta koji su obrađeni, i datacijski okvir je razmjerno širi te se kreće od 1. stoljeća pa do razdoblja kasne antike.
Kesäpäivät inhimillisen kasvun, eläinten ja luonnon teeman alla
Authors: Tähtinen Juhani , Pihlajaniemi Elise , Huttunen Rauno , Kortekangas Otso
Published: December 2022

Turussa kokoontui 16.–17.6.2022 reilu puolisataa kasvatuksen historiasta ja filosofiasta kiinnostunutta ihmistä esittämään ja keskustelemaan alan tuoreimmista tutkimuksellisista löydöksistä ja teemoista. Ihmiset oli saanut liikkeelle Kasvatuksen historian ja filosofian kesäpäivät, joita on järjestetty vuodesta 2005 lähtien vuosittain lukuun ottamatta pandemiavuotta 2020. Päivät järjestää Kasvatuksen historian ja filosofian verkosto yhdessä kulloinkin vuorossa olevan järjestävän yliopiston tutkijoiden kanssa.
Onko ekososiaalinen kasvatusteoretisointi riittävän ekofeminististä?
Authors: Paavilainen Aleksi
Published: December 2022

Kirjoitus on vastine artikkelini ”Sosialisaatio ja varhaiskasvatus kapitaloseenin aikakaudella – Ekososiaalisen kasvatusteorian ekofeministinen kritiikki” (Paavilainen 2022) saamiin vastineisiin (Pulkki, Foster & Keto 2022; Saari, Kallio & Varpanen 2022). Vastaan kritiikkeihin liittyen artikkelini ekososiaalisen kasvatusteorian rajaukseen, lähestymiseni ihmiskeskeisyyteen sekä antamiini kuviin itsekasvatuksesta ja leikistä. Summaan (eko)feminististen teoretisointien voivan tarjota vielä enemmän virikettä kasvatusta ja ympäristökysymyksiä käsittelevään tutkimukseen kuin mitä ekososiaalisen kasvatuksen tutkimusartikkeleista saa irti.
Perencanaan Pemeliharaan Mesin Produksi dengan Menggunakan Total Productive Maintenance untuk Menjamin Kestabilan Proses Produksi
Authors: Mauluddin Yusuf , Rahmawati Dewi , Oktavianti Dewi
Published: December 2022

Perkebunan Nusantara VIII adalah usaha yang bergerak di bidang produksi teh hitam, atau biasa disebut "teh Ortodoks" yang masih terkendala masalah efisiensi mesin. Komponen rusak sering terjadi pada mesin Withering Trough. Keadaan ini dapat mempengaruhi keterlambatan proses produksi dalam merespon pengurangan kapasitas produksi. Strategi penelitian ini menggunakan pendekatan Mix Method, dimana metode kualitatif dapat memberikan informasi hasil wawancara dan pengamatan langsung terhadap kondisi mesin dengan menggunakan Failure Mode and Effects Analysis untuk menentukan urutan prioritas masalah yang muncul, urutan masalah akan ditentukan. Menggunakan teknik Overall Equipment Effectiveness, data tentang perawatan dan kegagalan mesin yang terhubung dengan mesin manufaktur, Secara kuantitatif untuk menentukan performa mesin Hasil Penelitian Menunjukan bahwa nilai OEE pada mesin 61% masih berada dibawah standard Japanese Institute of Plant Maintenance untuk OEE 85%. Dari perhitungan Six Big Losses, rata-rata kerugian terbesar terdapat pada Defect In Process 64% dan Equipment failure 78%. Nilai RPN dengan nilai kegagalan tertinggi yaitu 150,144 dengan faktor komponen mesin yang sudah tidak persisis karena tidak ada maintanance berkala yang dilakukan terhadap mesin dan Kurangnya respon operator terhadap kerusakan mesin.
PENINGKATAN KESEJAHTERAAN MASYARAKAT TANI MELALUI PELATIHAN DAN PENDAMPINGAN ABON CABAI DI DUSUN TANGGUNG MULYO KEDIRI
Authors: Selah Nurul Ma'rifah  , MALA IVA , Sokhifatussaniyah  , Sutantri
Published: December 2022

The volatility of chili prices is a protracted problem that has not been completely resolved. Meanwhile, the majority of Dusun Responsibility Mulyo people are chili farmers whose livelihoods are supported by the sale of chili products. Therefore, this service is carried out with the aim of maintaining the stability of chili farmers' income which has an impact on the welfare of the Dusun Responsibility Mulyo community and stimulates the potential of MSMEs in the village. The method used is PAR and a case study approach with participatory observation. The solution that can be used is to conduct training and provide assistance in processing chili products into semi-finished processed materials, namely â€œAbon Cabaiâ€
PERANCANGAN PEMBANGKIT LISTRIK TENAGA SURYA 100 Wp UNTUK PENERANGAN LAMPU DI RUANG SELASAR FAKULTAS TEKNIK UNIVERSITAS RIAU KEPULAUAN
Authors: Gunoto Pamor , Sofyan Sofan
Published: December 2022

Pada saat era modern ini kebutuhan energi listrik merupakan suatu hal yang sangat penting dan vital bagi manusia.Saat ini energi listrik yang digunakan dari pemamfaatan sumber energi fosil seperti batu bara, gas alam dan minyak bumi. Pembangkit listrik tenaga surya (PLTS) merupakan salah satu energi terbarukan yang memamfaatkan energi dari sinar matahari dengan cara merubah radiasi sinar foton dari matahari menjadi energi listrik melalui media sel surya (photovoltaic). Saat ini dengan berkembangnya kegiatan perkuliahan di Fakultas Teknik Universitas Riau Kepulauan (UNRIKA), maka energi listrik yang dibutuhkan juga semakin besar. Salah satu pemamfaatan energi listrik yang sangat besar itu adalah lampu penerangan di ruangan selasar Fakultas Teknik. Penelitian ini memanfaatkan panel surya 100 Wp sebagai sumber listrik lampu penerangan di ruangan selasar Fakultas Teknik untuk penghematan penggunaan tenaga listrik. Setelah dilakukan pengujian dan pengambilan data pada PLTS yang dirancang, maka diperoleh hasil daya listrik dari panel surya 100 Wp sebesar 23,34 Watt. Untuk beban lampu listrik 360 watt selama 12 jam diperkirakan biaya listrik yang akan dikeluarkan sekitar Rp. 680.088 setiap tahunnya. Dengan biaya investasi awal pada PLTS yaitu Rp. 4.035.000, maka waktu yang dibutuhkan untuk pengembalian investasi awal adalah sekitar 5,9 tahun. Adapun biaya penghematan pemakain listrik perbulan yaitu Rp. 17.074.
Filtering Bleb Size in the Early Postoperative Period Affects the Long-term Surgical Outcome after Trabeculectomy
Authors: Jang Yoon Kyung , Choi Eui Jun , Son Dong Ook , Ahn Byung Heon , Han Jong Chul
Published: December 2022

Purpose: To investigate whether postoperative filtering bleb size affects the surgical outcome after trabeculectomy.Methods: In this study, we retrospectively reviewed 145 medically uncontrolled glaucoma patients with intraocular pressure (IOP) values >21 mmHg before surgery and data from ≥2 years of follow-up. Postoperative IOP, filtering bleb size including extent and height, and other clinical factors were measured after trabeculectomy. We divided bleb extent into quadrants and bleb height by 0.5 intervals of corneal thickness. The main outcome measure was surgical success. We confirmed complete success when the IOP was ≤21 mmHg and decreased by >20% from baseline without medication or additional procedures. Qualified success used the same criteria but allowed for medication or additional procedures. Cases with reoperation or two consecutive IOP measurements <6 mmHg were considered failures.Results: A total of 145 eyes of 145 patients was included. The average observation period was 30.8 ± 10.9 months. During multivariate Cox regression analysis, a larger extent of filtering bleb revealed significantly low hazard ratios in both complete and surgical success (0.509 and 0.494, respectively); however, there was no significant relationship between bleb height and surgical outcome.Conclusions: The extent of the filtering bleb was associated with surgical outcomes of trabeculectomy in glaucoma patients.
Pharyngeal Closure Reinforced With Sternohyoid and Omohyoid Muscle After Total Laryngectomy
Authors: Park Keon Woo , Jang Hye-Bin , Jung Eun Kyung , Lee Joon Kyoo
Published: December 2022

Pharyngocutaneous fistula occurring after total laryngectomy is a bothersome complication as it can even cause a massive bleeding due to carotid artery rupture. Preoperative radiation, extensive diseases which need flap reconstruction, low albumin or hemoglobin level, history of smoking, or underlying diseases have been domestically reported to have a relationship with the condition. To reduce this complication, simultaneous coverage for the pharyngeal closure has been developed using flaps, such as the pectoralis major muscle, the radial forearm or the anterolateral thigh, which are distant from the radiation field. However, these methods need additional surgical techniques and times. Another method advocated is pharyngeal reinforcement using flaps that can be easily obtained from the same surgical field, such as the sternocleidomastoid or the infrahyoid muscle or the acellular dermal graft with relative significances. Here we suggest reinforcement of pharyngeal closure after total laryngectomy using the sternohyoid and omohyoid muscle flaps.
Eventos adversos supuestamente atribuidos a la vacunación o inmunización (ESAVI) reportados a la vacuna contra la COVID-19 en el Instituto Nacional Materno Perinatal
Authors: Chipa Avila Mishel Rocio , Montoya Juro Carlos Jesús
Published: December 2022

Objetivo. Describir los ESAVI reportados en la inmunización realizada al personal de salud, con la vacuna Sinopharm (Vero cell) y verificar la causalidad de las sospechas de sus reacciones adversas. Material y métodos. El estudio tiene un enfoque cuantitativo y diseño transversal. Fue desarrollado en el Instituto Nacional Materno Perinatal en el año 2021, donde se evaluó a 60 trabajadores que manifestaron algún tipo de reacción posterior a la inmunización (primera y segunda dosis). Los instrumentos utilizados fueron la ficha de reporte de ESAVI y el instructivo del algoritmo de decisiones para la evaluación de causalidad de una RAM, Karch y Lasagna, propuesta por el Sistema Peruano de Farmacovigilancia de la DIGEMID. Resultados. Se verificó que el mayor porcentaje de reportes ESAVI se dio en el sexo femenino, entre las edades de 30 a 59 años. Las manifestaciones clínicas más reportadas fueron la cefalea, diarrea, mareos y debilidad. Se evidenció que las categorías asignadas como ¨probable¨, con un 84.8 %, y “definida”, con un 15.2 %, fueron el total de reportados. Además, en los ESAVI leve, el 75.8 % se ubicó en la categoría de “probable” y solo en la primera dosis se reportó un caso severo de ESAVI. Conclusiones. Los reportes más frecuentes se dieron en el sexo femenino y los ESAVI, definidos con la categoría de causalidad “probable”, fueron las más reportadas.
Glycerophosphate-dependent hydrogen peroxide production by rat liver mitochondria.
Authors: Ješina P , Kholová D , Bolehovská R , Červinková Z , Drahota Z , Houštěk J
Published: December 2022

We studied the extent to which hormonally-induced mitochondrial glycerophosphate dehydrogenase (mGPDH) activity contributes to the supply of reducing equivalents to the mitochondrial respiratory chain in the rat liver. The activity of glycerophosphate oxidase was compared with those of NADH oxidase and/or succinate oxidase. It was found that triiodothyronine-activated mGPDH represents almost the same capacity for the saturation of the respiratory chain as Complex II. Furthermore, the increase of mGPDH activity induced by triiodothyronine correlated with an increase of capacity for glycerophosphate-dependent hydrogen peroxide production. As a result of hormonal treatment, a 3-fold increase in glycerophosphate-dependent hydrogen peroxide production by liver mitochondria was detected by polarographic and luminometric measurements.
Selectins and monocyte chemotactic peptide as the markers of atherosclerosis activity.
Authors: Bláha M , Krejsek J , Bláha V , Andrýs J , Vokurková D , Malý J , Blažek M , Skořepová M
Published: December 2022

The role of adhesive selectin molecules in the process of atherogenesis is an open question. These molecules are known as markers of atherosclerosis activity, however, only some biological mechanisms are known up to now. In this study we examined the levels of soluble forms of E-, P-selectin and monocyte chemotactic protein (MCP-1) in the process of extracorporeal cholesterol elimination by LDL-apheresis. We measured the levels of sE-, sP-selectin and MCP-1 in the plasma before and after LDL-apheresis and in the washout solution from immunoabsorption columns Lipopak. Eighty measurements were performed repeatedly in 6 patients with severe familial hypercholesterolemia (FH) on long-term LDL-apheresis treatment. Before the procedure P-selectin levels were 204+/-179 ng/ml, E-selectin 32.1+/-33.7 ng/ml, MCP-1 323.8+/-121 pg/l, whereas after the procedure we found P-selectin levels 131.6+/-34 ng/ml, E-selectin 33.1+/-51 ng/ml, and MCP-1 200.4+/-15 pg/l. Levels of P-selectin were increased in the blood of patients with FH in spite of long-term intensive extracorporeal LDL-elimination, documenting thus the activity of atherosclerosis. The levels of P-selectin and MCP-1 decreased significantly after the hypolidemic procedure and could be used as another marker showing the effectivity of the extracorporeal LDL-cholesterol elimination (immediately after the procedure), and, after further verification, may serve as a marker for controlling the therapy efficacy.
Anti-GAD-positive patients with type 1 diabetes mellitus have higher prevalence of autoimmune thyroiditis than anti-GAD-negative patients with type 1 and type 2 diabetes mellitus.
Authors: Bárová H , Perušičová J , Hill M , Šterzl I , Vondra K , Mašek Z
Published: December 2022

The aim of our study was to evaluate antibodies against thyroglobulin (anti-TG) and thyroid peroxidase (anti-TPO) - markers of autoimmune thyroiditis - in several groups of adult patients with type 1 and type 2 diabetes mellitus (DM). We were particularly interested whether the presence of thyroid antibodies is related to the positivity of glutamic acid decarboxylase antibodies (anti-GAD). We found elevated anti-GAD in 46 % (97/210) patients with type 1 DM. All patients with type 2 diabetes were anti-GAD-negative. At least one thyroid antibody (anti-TG and/or anti-TPO) was found in 30 % (62/210) patients with type 1 DM and 27 % (22/83) type 2 diabetes patients. The patients with type 1 DM were further grouped according to their anti-GAD status. The anti-GAD-positive patients had a higher prevalence of anti-TG antibodies than the anti-GAD-negative patients (25 % vs. 12 %, p=0.03) as well as anti-TPO antibodies (32 % vs. 12 %, p<0.001). At least one thyroid antibody was detected in 39 % (38/97) of anti-GAD-positive but only in 21 % (24/113) of anti-GAD-negative patients with type 1 DM (p=0.006). No significant difference in the frequency of thyroid antibodies was found between anti-GAD-negative patients with type 1 and type 2 DM (21 % vs. 27 %, p=0.4). The groups with or without thyroid antibodies in both type 1 and type 2 diabetic patients did not differ in actual age, the age at diabetes onset, duration of diabetes, body mass index or HbA1c level. Patients with elevated thyroid antibodies had significantly higher levels of TSH than those without thyroid antibodies (1.86 vs. 3.22 mIU/l, p=0.04 in type 1 DM; 2.06 vs. 4.89 mIU/l, p=0.003 in type 2 DM). We conclude that there is a higher frequency of thyroid-specific antibodies in anti-GAD-positive adult patients with type 1 DM than in anti-GAD-negative patients or in patients with type 2 DM. Patients with or without thyroid antibodies do not differ in age, DM onset and duration, BMI or HbA1c. Thyroid antibodies-positive patients have higher levels of thyroid stimulating hormone (TSH).
Fibroids and Infertility
Authors: El Mahdi Essam
Published: December 2022

Infertility is generally defined as the failure to conceive after ≥1 year of unprotected sexual intercourse. Because infertility tends to be multicausal, fibroids (as the sole identified factor for infertility) were only identified in about 2.4% of patients. Uterine fibroids, also known as myomas, are benign growths of the uterus’ smooth muscle tissue. They are the most common tumours to be found in the lower abdomen in pre-menopausal women. Fibroids can be found in 30–40% of all women between the age of 30 and 40 but can occur at any age. Furthermore, they are more prevalent in African women than in women of other ethnicities. The relationship between fibroids and infertility is especially difficult because of the heterogeneity of the fibroids regarding their size, location, and number, as well as the heterogeneity in observed patient populations. Even though a number of studies have attempted to clarify the influence of fibroids on fertility, there have been various, sometimes contradictory, findings and a lack of well-designed trials.
A Modern Approach to Progesterone Supplementation
Authors: Labarta Elena
Published: December 2022

At the end of December 2017, some colleagues and I reported results from a prospective cohort study (N=211) into the relationship between serum progesterone (P) and endometrial volume on the day of embryo transfer (ET) and ongoing pregnancy rates (OPR) in artificial endometrium preparation cycles.1
Mozgásszervi fájdalmak a hazai gyakorlatban – klinikai jellemzők és funkcionális összefüggéseik vizsgálata
Authors: Hodinka László
Published: December 2022

Felmérésünk céljául a napi gyakorlatban jelentkező fájdalmak jellemzőinek (regionalitás, erősség és funkcionális következmények) a betegjellemzőkkel (nem, életkor, reumatológiai alapbetegségek, társbetegségek) való összevetését és összefüggéseik elemzését tűztük ki. Nyolc­van­négy társvizsgáló rögzítette a mozgásszervi és a társuló betegségeket, a fájdalom fennállásának időtartamát, regionalitását, erősségét és a fájdalom öt területen jelzett kö­vetkezményét (a szokásos életvitel, napi te­vékenységek, mozgásképesség és az alvás nehezítettsége, valamint az általuk keltett aggodalom mértéke). Az adatok számszerű értékeit és összefüggéseiket epidemiológiai statisztikai módszerekkel elemeztük. A fájdalom erőssége és a fájdalomkövetkezmények átlagai a degeneratív gerincbetegségek csoportjában voltak a legnagyobbak. A nem mozgásszervi társbetegségek jelenléte nem generált többletfájdalmat vagy funkcionális hátrányt. A fájdalom erőssége és a fájdalomkövetkezmények a három hónapnál régebben fennálló fájdalmak esetében voltak a legsúlyosabbak. Felmérésünk adatai olyan többdimenziós koordinátarendszert képeznek – a fájdalom erőssége, várható funkcionális következményei és fennállási ideje, az alapbetegség, társbetegségek fenn­állása vagy hiánya és az anatómiai régiók szerint –, amelybe az aktuális beteg elhelyezhető. Ez támpontot adhat az ak­tuá­lis panasz súlyozásához, az analgetikus stratégia megtervezéséhez és a készítmény megválasztásához.
Válogatás a hálózatalapú járványterjedési modellek eredményeiből
Authors: Bóta András , Hajdu László , Brys Zoltán , Krész Miklós
Published: December 2022

A matematikai értelemben vett gráfok vagy hálózatok sokoldalú, szemléletes modellezési eszközt biztosítanak más tudományterületek számára, többek között az orvos­tudomány számára is. Ebben a közleményben a fertőző betegségekkel kapcsolatos hálózati modelleket ismertetjük röviden. Az ismert, a tudományterület szakirodalmában meglévő eszközökön felül a fertőzési folyamatot kiválóan lehet modellezni hálózatokkal is. A téma életszerűségét kiválóan bizonyítja a használt modellek sokszínűsége, az alkalmazások sokoldalúsága és a témával kapcsolatos tudományos közlemények nagy száma. A téma méretéből adódóan ebben a közleményben csak a hálózatalapú járványterjedési modellek alapfogalmait és alapvető típusait tudjuk ismertetni, valamint néhány gyakorlati példával szemléltetjük alkalmazhatóságukat.
A Research on Determining the Senior Level Managerial Competencies for Container Ports in Türkiye
Authors: BARAN KASAPOĞLU Esra , AYAN Serdar
Published: December 2022

As essential and significant interfaces in the maritime transportation chain, ports operate in a dynamic and competitive environment. Port managers’ competencies are critical intellectual capital for ports to react to the demands of this changing environment. This research aims to identify the critical managerial competencies of container port senior managers in strategically managing the container port in a dynamic and competitive environment. The study was carried out in two steps, and structured interview and Delphi methods were used. As a result, 26 critical managerial competencies for senior managers of container ports are determined in this study, including technical and operational, human and social, cognitive and conceptual competencies. The outcomes of this study are expected to contribute to the relevant literature and provide useful insights to practitioners in designing and implementing human resource development strategies in port management.
A New Maximum Length for the Grey Triggerfish, Balistes capriscus Gmelin, 1789 for the Mediterranean Sea and First Confirmed Record in the Çanakkale Strait (Turkish Strait System)
Authors: KALE Semih , TAN Evren
Published: December 2022

A single specimen of the grey triggerfish, Balistes capriscus Gmelin, 1789, was caught by a speargun at 18 m water depth in the vicinity of the Çanakkale Strait in the Turkish Straits System, between the Aegean Sea and the Marmara Sea. Its total length was 57.8 cm and weight was 2270 g. The given size is the maximum observed length for the grey triggerfish, B. capriscus, in the Mediterranean Sea. In addition, this paper also documented the first confirmed record of the grey triggerfish, B. capriscus in the Çanakkale Strait (the Turkish Straits System).
Determination of Shelf Life During Cold Storage of Fish Fingers Coated Addition of Goji Berry
Authors: GÜREL İNANLI Ayşe , MUHAMMED AMİN Brzo Latif
Published: December 2022

The present study was aimed to evaluate shelf life of Pike Barbell (Luciobarbus esocinus Heckel, 1843) experimental samples of fish finger, that ordinarily packed and stored at 4±1°C. Together with the control group, three experimental groups fish finger were obtained with the addition of the goji berry extract into this content by 1% and 2%. According to the findings obtained in this study, it was concluded that fish fingers with goji berry addition had a positive effect on chemical, microbiological and sensory qualities and this study could also establish a basis for many scientific studies with the application of herbal extracts used in experimental samples on various fish products in more different concentration.
Role of Seaweeds in Drug Induced Nephrotoxicity
Authors: SOHAİL Nida , FARHAT Hafiza
Published: December 2022

Kidney is an important organ which is necessary for the body to perform various important functions which include blood purification, expelling metabolic wastes and managing water and electrolytes balance in the body. In this era of modern science, many synthetic drugs are used on patients to examine their therapeutic properties. Unfortunately, some drugs cause negative effects resulting in renal damage. Drug induced nephrotoxicity results in serious clinical syndromes, such as chronic kidney disease (CKD) and acute kidney injury (AKI). Synthetic drugs not only cure diseases but also cause some side effects in the human body. Instead of looking for synthetic drugs to cure diseases, it is necessary to consider natural drugs that maximize side effects of synthetic drugs and reduce therapeutic consequences with the most effective and dynamic healing effects. Research and utilization of marine algae have increased markedly from the last several decades. Seaweeds have also been used as drugs or drug sources over a large number of years going back into folk medicine. Since consumption of seaweeds as human food or animal feeds is increasing rapidly. In the current review, we have summarized the information regarding the drugs which cause nephrotoxicity and marine algae as seaweeds used for the treatment of nephrotoxicity.
Information and communication impact on the transformation of the management system of business organizations
Authors:   National University of Ukraine on Physical Education and Sport, KHARCHUK Tetiana , POPROZMAN Oleksandr ,   National University of Ukraine on Physical Education and Sport, MELNIK Victoria ,   Kyiv National University of Trade and Economics
Published: December 2022

The role of the use of information and communication technologies in business organizations has been studied and the necessary prerequisites for their improvement in the era of constant transformational changes have been determined. Approaches to determining the essence and value of economic information to ensure effective management of all business processes have been considered. Also it has been found that the change of views on the development of economic information is associated with the rapid development of events in the world, which stimulates the emergence of new concepts as a means responding to today's problems, which will allow determining the priorities of the country's economic development and form the principles of business entities adequate to modern conditions. The essence and significance of information and communication support of the management system in business organizations are clarified.
Perspektif Filosofis dalam Pendidikan Terbuka dan Jarak Jauh
Authors: Arditya Prayogi
Published: December 2022

Kajian filosofis atas berbagai sistem belajar atau pendidikan secara umum menjadi penting sebagai dasar dalam menilai maupun mengeksekusi berbagai kebijakan dalam pendidikan. Termasuk dalam pembelajaran terbuka dan jarak jauh, dimana landasan filosofisnya perlu dijabarkan agar proses pembelajaran di dalamnya dapat berjalan dengan lebih maksimal. Artikel ini bertujuan untuk menjabarkan bagaimana perspektif filosofis berupa ontologi, epistemologi, aksiologi, dan juga etika diterjemahkan dalam pelaksanaan sistem pembelajaran terbuka dan jarak jauh. Artikel ini disusun dengan metode deskriptif kualitatif yang ditunjang dengan pengumpulan data dengan metode studi pustaka. Dari hasil pembahasan diketahui bahwa secara filosofis, sistem PTJJ merupakan upaya yang dapat memungkinkan terpenuhinya kebutuhan pendidikan yang berdasarkan pada hakikat manusia, berupa keberbedaan, baik minat, kebutuhan dan kondisi kemampuan individu, serta menggunakan asas kesetaraan sebagai nilai filosofis di dalamnya.
Distance Learning Based on Human Literacy: An Alternative Learning to Foster Public Civility
Authors: Kusnadi Kusnadi
Published: December 2022

The crisis of community identity reflects the neglect of the world of Education and culture to develop civic intelligence. Education emphasizes individual intelligence by ignoring efforts to link emotional intelligence diversity with collective citizenship intelligence. As a result, many people are unaware of their obligations and rights. In addition, many behaviors do not reflect politeness in society. Recently, blasphemy, insults, insults, and even threats are so easy to find in various places in public spaces. Therefore, civil intelligence education is the best solution for shaping public civility. Mental intelligence development is essential for a nation. It is necessary to develop literacy that can lead to a more noble and civilized life, namely human literacy. Human literacy is the estuary of data and technology literacy for 21st-century students for a more noble and civilized life. Distance Education has a significant role in building the quality of Education in Indonesia, especially in developing human literacy. The method used in the analysis of this discussion is a literature study. This article discusses civic intelligence as a challenge, distance education as a solution to the civic intelligence education process, the development of civic intelligence through human literacy, and the role of human literacy in shaping public civility in distance education.
Molecular detection of Babesia bovis along with haemato-biochemical alterations in large ruminants associated with babesiosis in central Punjab, Pakistan
Authors: Ali Mubarik , Jamil Muhammad , Jabeen Norina , Gul Jaweria , Kashif Muhammad , Khan Imtiaz , Ullah Naimat
Published: December 2022

Babesiosis is endemic in Pakistan and is one of the most important bovine diseases that cause huge economic losses and high mortality in young animals. A hematobiochemical study was conducted to unveil the difference between diseased and healthy animals in specific districts i.e., Faisalabad, Toba Tek Singh and Jhang of Punjab, Pakistan. The total number of blood samples collected were 518 which include samples of 158 buffaloes and 360 cattle. The collected samples are then analyzed with the help of PCR (Polymerase Chain Reaction) targeting apocytochrome b-genes (CYTb) followed by hematobiochemical analysis. The analysis of data was done by the Chi-square test. The PCR tests conducted in summer suggests that 53 out of 180 (29.4%) cows and 19 out of 79 (24.05%) buffaloes are prone to babesiosis. On the other hand, in winter results showed that 12.7 (23/180), 13.92 % (11/79) samples positive for Babesia genus through c-PCR. The positive samples were further investigated for hematological and biochemical analysis. The results revealed that, the mean value of hematological parameters like RBCs, Hb, PCV, MCV and MCHC was significantly (P< 0.05) decreased in infected animals (cows and buffaloes) as compared to the non-infected ones. While the biochemical parameters like ALT, AST, Cholesterol and LDH were significantly (P< 0.05) increased in infected animals as compared to healthy animals. These findings are the novel molecular and hematobiochemical evidence of B. bovis in dairy herds of Punjab province, Pakistan.
Inference of dynamic interaction networks: A comparison between Lotka-Volterra and multivariate autoregressive models
Authors: Olivença Daniel V. , Davis Jacob D. , Voit Eberhard O.
Published: December 2022

Networks are ubiquitous throughout biology, spanning the entire range from molecules to food webs and global environmental systems. Yet, despite substantial efforts by the scientific community, the inference of these networks from data still presents a problem that is unsolved in general. One frequent strategy of addressing the structure of networks is the assumption that the interactions among molecular or organismal populations are static and correlative. While often successful, these static methods are no panacea. They usually ignore the asymmetry of relationships between two species and inferences become more challenging if the network nodes represent dynamically changing quantities. Overcoming these challenges, two very different network inference approaches have been proposed in the literature: Lotka-Volterra (LV) models and Multivariate Autoregressive (MAR) models. These models are computational frameworks with different mathematical structures which, nevertheless, have both been proposed for the same purpose of inferring the interactions within coexisting population networks from observed time-series data. Here, we assess these dynamic network inference methods for the first time in a side-by-side comparison, using both synthetically generated and ecological datasets. Multivariate Autoregressive and Lotka-Volterra models are mathematically equivalent at the steady state, but the results of our comparison suggest that Lotka-Volterra models are generally superior in capturing the dynamics of networks with non-linear dynamics, whereas Multivariate Autoregressive models are better suited for analyses of networks of populations with process noise and close-to linear behavior. To the best of our knowledge, this is the first study comparing LV and MAR approaches. Both frameworks are valuable tools that address slightly different aspects of dynamic networks.
Algorithms to anonymize structured medical and healthcare data: A systematic review
Authors: Sepas Ali , Bangash Ali Haider , Alraoui Omar , El Emam Khaled , El-Hussuna Alaa
Published: December 2022

Introduction: With many anonymization algorithms developed for structured medical health data (SMHD) in the last decade, our systematic review provides a comprehensive bird’s eye view of algorithms for SMHD anonymization.

Methods: This systematic review was conducted according to the recommendations in the Cochrane Handbook for Reviews of Interventions and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Eligible articles from the PubMed, ACM digital library, Medline, IEEE, Embase, Web of Science Collection, Scopus, ProQuest Dissertation, and Theses Global databases were identified through systematic searches. The following parameters were extracted from the eligible studies: author, year of publication, sample size, and relevant algorithms and/or software applied to anonymize SMHD, along with the summary of outcomes.

Results: Among 1,804 initial hits, the present study considered 63 records including research articles, reviews, and books. Seventy five evaluated the anonymization of demographic data, 18 assessed diagnosis codes, and 3 assessed genomic data. One of the most common approaches was k-anonymity, which was utilized mainly for demographic data, often in combination with another algorithm; e.g., l-diversity. No approaches have yet been developed for protection against membership disclosure attacks on diagnosis codes.

Conclusion: This study reviewed and categorized different anonymization approaches for MHD according to the anonymized data types (demographics, diagnosis codes, and genomic data). Further research is needed to develop more efficient algorithms for the anonymization of diagnosis codes and genomic data. The risk of reidentification can be minimized with adequate application of the addressed anonymization approaches.

Systematic Review Registration: [http://www.crd.york.ac.uk/prospero], identifier [CRD42021228200].
Adenoviral VEGF-DΔN ΔC gene therapy for myocardial ischemia
Authors: Pajula Juho , Lähteenvuo Johanna , Lähteenvuo Markku , Honkonen Krista , Halonen Paavo , Hätinen Olli-Pekka , Kuivanen Antti , Heikkilä Minja , Nurro Jussi , Hartikainen Juha , Ylä-Herttuala Seppo
Published: December 2022

Background: Cardiovascular diseases are the leading cause of death globally. In spite of the availability of improved treatments, there is still a large group of chronic ischemia patients who suffer from significant symptoms and disability. Thus, there is a clear need to develop new treatment strategies for these patients. Therapeutic angiogenesis is a novel therapy method which has shown promising results in preclinical studies. In this study, we evaluated safety and efficacy of adenoviral (Ad) VEGF-DΔNΔC gene transfer for the treatment of myocardial ischemia in a pig model.

Methods: Adenoviral VEGF-DΔNΔC gene transfer was given to pigs (n = 26) via intramyocardial injections using an electromechanical injection catheter. Angiogenic effects were evaluated in an acute myocardial infarction model (n = 18) and functionality of the lymphatic vessels were tested in healthy porcine myocardium (n = 8). AdLacZ was used as a control.

Results: AdVEGF-DΔNΔC induced safe and effective myocardial angiogenesis by inducing a four-fold increase in mean capillary area at the edge of the myocardial infarct six days after the gene transfer relative to the control AdLacZ group. The effect was sustained over 21 days after the gene transfer, and there were no signs of vessels regression. AdVEGF-DΔNΔC also increased perfusion 3.4-fold near the infarct border zone relative to the control as measured by fluorescent microspheres. Ejection fraction was 8.7% higher in the AdVEGF-DΔNΔC treated group 21 days after the gene transfer relative to the AdLacZ control group. Modified Miles assay detected a transient increase in plasma protein extravasation after the AdVEGF-DΔNΔC treatment and a mild accumulation of pericardial effusate was observed at d6. However, AdVEGF-DΔNΔC also induced the growth of functional lymphatic vasculature, and the amount of pericardial fluid and level of vascular permeability had returned to normal by d21.

Conclusion: Endovascular intramyocardial AdVEGF-DΔNΔC gene therapy proved to be safe and effective in the acute porcine myocardial infarction model and provides a new potential treatment option for patients with severe coronary heart disease.
Pharmacists’ role in diabetes management for persons with lived experience of homelessness in Canada: A qualitative study
Authors: McSweeney Breanna , Campbell Rachel B. , Grewal Eshleen K. , Campbell David J. T.
Published: December 2022

Introduction

Persons with lived experience of homelessness face many challenges in managing diabetes, including purchasing and storing medications, procuring healthy food and accessing healthcare services. Prior studies have found that pharmacy-led interventions for diabetes improved A1C, and lowered blood pressure and cholesterol in general populations. This study evaluated how select pharmacists in Canada have tailored their practices to serve persons with lived experiences of homelessness with diabetes.

Methods

We conducted a qualitative descriptive study using open-ended interviews with inner-city pharmacists in select Canadian municipalities (Calgary, Edmonton, Vancouver, and Ottawa). We used NVivo qualitative data analysis software to facilitate thematic analysis of the data, focusing on how pharmacists contributed to diabetes care for persons with lived experience of homelessness.

Results

These pharmacists developed diabetes programs after discovering an unmet need in the population. Pharmacists have the unique ability to see patients frequently, allowing tailored education and hands-on assistance with diabetes management. These pharmacists provided extra-ordinary care like financial and housing resources and many of them were uniquely embedded within other services for persons with lived experience of homelessness (i.e. housing and social work supports). Pharmacists reported struggling with balancing optimal medical care for individuals with the financial constraints of running a business.

Conclusion

Pharmacists are vital members of the diabetes care team for persons with lived experience of homelessness. Government policies should support and encourage unique models of care provided by pharmacists to improve diabetes management for this population.
Total synthesis of justicidin B, justicidin E, and taiwanin C: A general and flexible approach toward the synthesis of natural arylnaphthalene lactone lignans
Authors: Wei Kai , Sun Yucui , Xu Yiren , Hu Wen , Ma Ying , Lu Yi , Chen Wen , Zhang Hongbin
Published: December 2022

Lignans are widely present in traditional medicinal plants. Many natural arylnaphthalene lactone lignans (NALLs) isolated from the genera Justicia, Haplophyllum, and Phyllanthus possess interesting biological activities. Herein, we report a general strategy for the total synthesis of this kind of lignans. Features of this new approach are an aryl–alkyl Suzuki cross-coupling to introduce the dioxinone unit, a cation-induced cyclization to construct the aryl dihydronaphthalene, and base-mediated oxidative aromatization to furnish the arylnaphthalene core. By incorporating these key transformations, the total syntheses of justicidins B and E and taiwanin C covered type I and type II NALLs were accomplished.
Petri-plate, bacteria, and laser optical scattering sensor
Authors: Bhunia Arun K. , Singh Atul K. , Parker Kyle , Applegate Bruce M.
Published: December 2022

Classical microbiology has paved the path forward for the development of modern biotechnology and microbial biosensing platforms. Microbial culturing and isolation using the Petri plate revolutionized the field of microbiology. In 1887, Julius Richard Petri invented possibly the most important tool in microbiology, the Petri plate, which continues to have a profound impact not only on reliably isolating, identifying, and studying microorganisms but also manipulating a microbe to study gene expression, virulence properties, antibiotic resistance, and production of drugs, enzymes, and foods. Before the recent advances in gene sequencing, microbial identification for diagnosis relied upon the hierarchal testing of a pure culture isolate. Direct detection and identification of isolated bacterial colonies on a Petri plate with a sensing device has the potential for revolutionizing further development in microbiology including gene sequencing, pathogenicity study, antibiotic susceptibility testing , and for characterizing industrially beneficial traits. An optical scattering sensor designated BARDOT (bacterial rapid detection using optical scattering technology) that uses a red-diode laser, developed at the beginning of the 21st century at Purdue University, some 220 years after the Petri-plate discovery can identify and study bacteria directly on the plate as a diagnostic tool akin to Raman scattering and hyperspectral imaging systems for application in clinical and food microbiology laboratories.
Assessing clinical and biomarker characteristics to optimize the benefits of sacubitril/valsartan in heart failure
Authors: Litwin Sheldon E. , East Cara A.
Published: December 2022

Of the various medical therapies for heart failure (HF), sacubitril/valsartan is a first-in-class angiotensin receptor-neprilysin inhibitor that combines sacubitril, a pro-drug that is further metabolized to the neprilysin inhibitor sacubitrilat, and the angiotensin II type 1 receptor blocker valsartan. Inhibition of neprilysin and blockade of the angiotensin II type 1 receptor with sacubitril/valsartan increases vasoactive peptide levels, increasing vasodilation, natriuresis, and diuresis. Left ventricular ejection fraction (LVEF) is widely used to classify HF, to assist with clinical decision-making, for patient selection in HF clinical trials, and to optimize the benefits of sacubitril/valsartan in HF. However, as HF is a complex syndrome that occurs on a continuum of overlapping and changing phenotypes, patient classification based solely on LVEF becomes problematic. LVEF measurement can be imprecise, have low reproducibility, and often changes over time. LVEF may not accurately reflect inherent disease heterogeneity and complexity, and the addition of alternate criteria to LVEF may improve phenotyping of HF and help guide treatment choices. Sacubitril/valsartan may work, in part, by mechanisms that are not directly related to the LVEF. For example, this drug may exert antifibrotic and neurohumoral modulatory effects through inhibition or activation of several signaling pathways. In this review, we discuss markers of cardiac remodeling, fibrosis, systemic inflammation; activation of neurohormonal pathways, including the natriuretic system and the sympathetic nervous system; the presence of comorbidities; patient characteristics; hemodynamics; and HF signs and symptoms that may all be used to (1) better understand the mechanisms of action of sacubitril/valsartan and (2) help to identify subsets of patients who might benefit from treatment, regardless of LVEF.