bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk and Protective Factors Associated With Intimate Partner Violence Against Chinese Women: A Systematic Review
Authors: Cao Jiepin , Lee Chi-Young , Liu Xu , Gonzalez-Guarda Rosa M.
Published: July 2021

Intimate partner violence (IPV) is a global health challenge leading to various detrimental health outcomes. Chinese women are a vulnerable population often overlooked in IPV research. Guided by the social–ecological model, this systematic review aims to synthesize literature on the risk and protective factors for IPV among Chinese women. A comprehensive search was conducted in nine major English and Chinese databases for articles with data collected since 2006 on adult Chinese women, leading to 29 papers in the final analysis. Risk and protective factors associated with IPV identified in this review include factors at the individual level such as demographics (e.g., a younger age, unplanned pregnancy, abortion, having children, and migration), socioeconomic status (e.g., income and partners’ education level), attitudinal factors (e.g., attitudes justifying IPV and traditional beliefs about gender roles), behavioral factors (e.g., alcohol use of women, partners’ alcohol use and frequency, and partners’ high frequency of gambling), adverse childhood experiences (e.g., witnessed violence in childhood), and other personal characteristics (e.g., chronic illness and good health status). Factors at the relationship level include conflicts, power in intimate relationships, and social capital (e.g., the size of social networks, network participation of women and their partners, and social control). Community-level factors related to geographic locations were also explored while no factors were identified at the societal level. None of the included studies examined the intersections of factors within the same level or across different levels. Recommendations for future research, practice, and policy are also discussed.
Postcolonial M/Othering: Poetics of Remembering and Writing as an Invitation to Rememory
Authors: Rashid Mariam , Jocson Korina M.
Published: July 2021

To open up possibilities in inquiry, the authors write in a manner that extends a lens of postcolonial m/Othering through poetic autoethnography. They draw on the conceptualization of rememory to work with/through memories of their own as mothers for the sake of daughters. Building on poetics of remembering, the authors braid their experiences from Kenya and the Philippines, within remnants of colonialism and its tentacles, inviting the reader on a telling-sharing dialogic-rhythmic-groove that is personal and political and haunting at the same time. The possibilities for transdisciplinary methodologies unfold in the telling-sharing and point to the in-between curiosities of knowing and unknowing. This collaborative and creative (re)membering is an invitation to rememory, to rework the past-present-future, a chance at world-making.
Effect of the ratio of vessel-specific volume to fractional myocardial mass on fractional flow reserve
Authors: Liu Jincheng , Li Bao , Ma Junling , Wang Xue , Zhang Liyuan , Mao Boyan , Liu Youjun
Published: July 2021

This study aimed to examine whether the ratio of vessel-specific coronary arterial lumen volume to the fraction of myocardial mass (VR/MR) affects myocardial ischemia. We proposed a calculation method for VR/MR, and compared the ratio of total epicardial coronary arterial lumen volume to left ventricular myocardial mass (V/M) with VR/MR in predicting myocardial ischemia. VR/MR and V/M were computed using data from 205 patients with 241 stenosis vessel who underwent coronary computed tomography angiography (CTA), quantitative coronary angiography, and fractional flow reserve. The vessel-specific coronary arterial lumen volume (VR) was obtained from CTA by segmenting the coronary arterial lumen volume, while the vessel-specific fraction of myocardial mass (MR) was obtained by allometric scaling. The VR/MR was then calculated. The cut-off values of V/M (23.55 mm3/g) and VR/MR (12.98 mm3/g) were used to define equal groups of ischemic and non-ischemic patients, respectively. Using these cut-off values, the accuracy, specificity, sensitivity, positive predictive value, and negative predictive value of V/M were 60%, 76%, 45%, 57%, and 66%, and of VR/MR were 87%, 92%, 77%, 89%, and 83%, respectively. Patients have different VR/MR values in different stenotic coronary arteries. Clinically, VR/MR is a quantitative indicator of the risk of myocardial ischemia.
Asynchronous event feature generation and tracking based on gradient descriptor for event cameras
Authors: Li Ruoxiang , Shi Dianxi , Zhang Yongjun , Li Ruihao , Wang Mingkun
Published: July 2021

Recently, the event camera has become a popular and promising vision sensor in the research of simultaneous localization and mapping and computer vision owing to its advantages: low latency, high dynamic range, and high temporal resolution. As a basic part of the feature-based SLAM system, the feature tracking method using event cameras is still an open question. In this article, we present a novel asynchronous event feature generation and tracking algorithm operating directly on event-streams to fully utilize the natural asynchronism of event cameras. The proposed algorithm consists of an event-corner detection unit, a descriptor construction unit, and an event feature tracking unit. The event-corner detection unit addresses a fast and asynchronous corner detector to extract event-corners from event-streams. For the descriptor construction unit, we propose a novel asynchronous gradient descriptor inspired by the scale-invariant feature transform descriptor, which helps to achieve quantitative measurement of similarity between event feature pairs. The construction of the gradient descriptor can be decomposed into three stages: speed-invariant time surface maintenance and extraction, principal orientation calculation, and descriptor generation. The event feature tracking unit combines the constructed gradient descriptor and an event feature matching method to achieve asynchronous feature tracking. We implement the proposed algorithm in C++ and evaluate it on a public event dataset. The experimental results show that our proposed method achieves improvement in terms of tracking accuracy and real-time performance when compared with the state-of-the-art asynchronous event-corner tracker and with no compromise on the feature tracking lifetime.
What Happened to Mirror Neurons?
Authors: Heyes Cecilia , Catmur Caroline
Published: July 2021

Ten years ago, Perspectives in Psychological Science published the Mirror Neuron Forum, in which authors debated the role of mirror neurons in action understanding, speech, imitation, and autism and asked whether mirror neurons are acquired through visual-motor learning. Subsequent research on these themes has made significant advances, which should encourage further, more systematic research. For action understanding, multivoxel pattern analysis, patient studies, and brain stimulation suggest that mirror-neuron brain areas contribute to low-level processing of observed actions (e.g., distinguishing types of grip) but not to high-level action interpretation (e.g., inferring actors’ intentions). In the area of speech perception, although it remains unclear whether mirror neurons play a specific, causal role in speech perception, there is compelling evidence for the involvement of the motor system in the discrimination of speech in perceptually noisy conditions. For imitation, there is strong evidence from patient, brain-stimulation, and brain-imaging studies that mirror-neuron brain areas play a causal role in copying of body movement topography. In the area of autism, studies using behavioral and neurological measures have tried and failed to find evidence supporting the “broken-mirror theory” of autism. Furthermore, research on the origin of mirror neurons has confirmed the importance of domain-general visual-motor associative learning rather than canalized visual-motor learning, or motor learning alone.
Diagnosis and Treatment of Snapping Scapula Syndrome: A Scoping Review
Authors: Baldawi Hassan , Gouveia Kyle , Gohal Chetan , Almana Latifah , Paul Ryan , Alolabi Bashar , Moro Jaydeep , Khan Moin
Published: July 2021

Context:

Snapping scapula syndrome (SSS) is commonly misdiagnosed and underreported due to lack of awareness.

Objective:

This scoping review aims to summarize the current evidence related to SSS diagnosis and treatment to aid clinicians in managing the condition more effectively.

Data Sources:

PubMed, Medline, and Embase databases were searched for studies related to the etiology, diagnosis, or treatment of SSS (database inception to March 2020).

Study Selection:

Databases were searched for available studies related to the etiology, diagnosis, or treatment of SSS.

Study Design:

A scoping review study design was selected to explore the breadth of knowledge in the literature regarding SSS diagnosis and treatment.

Level of Evidence:

Level 4.

Data Extraction:

Primary outcomes abstraction included accuracy of diagnostic tests, functional outcomes, and pain relief associated with various nonoperative and operative treatment options for SSS.

Results:

A total of 1442 references were screened and 40 met the inclusion criteria. Studies commonly reported SSS as a clinical diagnosis and relied heavily on a focused history and physical examination. The most common signs reported were medial scapular border tenderness, crepitus, and audible snapping. Three-dimensional computed tomography had high interrater reliability of 0.972, with a 100% success rate in identifying symptomatic incongruity of the scapular articular surface. Initial nonoperative treatment was reported as successful in most symptomatic patients, with improved visual analogue scale (VAS) scores (7.7 ± 0.5 pretreatment, to 2.4 ± 0.6). Persistently symptomatic patients underwent surgical intervention most commonly involving bursectomy, superomedial angle resection, or partial scapulectomy. High satisfaction rates of surgery were reported in VAS (6.9 ± 0.7 to 1.9 ± 0.9), American Shoulder and Elbow Surgeons scores (50.3 ± 12.2 to 80.6 ± 14.9), and mean simple shoulder test scores (5.6 ± 1.0 to 10.2 ± 1.1).

Conclusion:

Focused history and physical examination is the most crucial initial step in the diagnostic process, with supplemental imaging used to assess for structural etiologies when nonoperative management fails. Nonoperative management is as effective as surgical management in pain relief and is advised for 3 to 6 months before operative treatment.
Keep silence for yourself: The protection of the right to silence in the Italian criminal justice system
Authors: Marchesi Diletta , Panzavolta Michele
Published: July 2021

The present article aims to discuss the protection of the right to silence in the Italian criminal justice system for an international audience. In Italy, the right to silence is a right that stems directly from the protection offered by the Constitution to the right of defence. Much debate revolves around the extent to which the right deserves to be safeguarded. Although the majority of scholarship favours the broadest extension of the right possible, this view is not endorsed unanimously. The legislature has introduced some limits, the most important being that which confines the right to silence to the facts concerning one’s own responsibility, save for exceptions. The courts, in turn, have taken a softer approach in the protection of the right to silence, which may allow the possibility of using the suspect’s silence to draw adverse consequences. Although the Italian system offers comparatively strong protection to the right to silence, it nonetheless leaves some openings that undermine the effectiveness of the right. This article therefore argues that compensating for the possible side effects of the rules on cooperation, removing some negative consequences of silence and the strengthening of remedies are the main fronts where the Italian system can still improve the protection of the right to silence.
Phosphoproteomic analysis of lung tissue from patients with pulmonary arterial hypertension
Authors: Sitapara Ravikumar , Lam TuKiet T. , Gandjeva Aneta , Tuder Rubin M. , Zisman Lawrence S.
Published: July 2021

Pulmonary arterial hypertension (PAH) is a rare disorder associated with high morbidity and mortality despite currently available treatments. We compared the phosphoproteome of lung tissue from subjects with idiopathic PAH (iPAH) obtained at the time of lung transplant with control lung tissue. The mass spectrometry‐based analysis found 60,428 phosphopeptide features from which 6622 proteins were identified. Within the subset of identified proteins there were 1234 phosphopeptides with q < 0.05, many of which are involved in immune regulation, angiogenesis, and cell proliferation. Most notably there was a marked relative increase in phosphorylated (S378) IKZF3 (Aiolos), a zinc finger transcription factor that plays a key role in lymphocyte regulation. In vitro phosphorylation assays indicated that GSK3 alpha and/or GSK3 beta could phosphorylate IKZF3 at S378. Western blot analysis demonstrated increased pIKZF3 in iPAH lungs compared to controls. Immunohistochemistry demonstrated phosphorylated IKZF3 in lymphocytes surrounding severely hypertrophied pulmonary arterioles. In situ hybrization showed gene expression in lymphocyte aggregates in PAH samples. A BCL2 reporter assay showed that IKZF3 increased BCL2 promoter activity and demonstrated the potential role of phosphorylation of IKZF3 in the regulation of BCL mediated transcription. Kinase network analysis demonstrated potentially important regulatory roles of casein kinase 2, cyclin‐dependent kinase 1 (CDK1), mitogen‐associated protein kinases (MAPKs), and protein kinases (PRKs) in iPAH. Bioinformatic analysis demonstrated enrichment of RhoGTPase signaling and the potential importance of cGMP‐dependent protein kinase 1 (PRKG). In conclusion, this unbiased phosphoproteomic analysis demonstrated several novel targets regulated by kinase networks in iPAH, and reinforced the potential role of immune regulation in the pathogenesis of iPAH. The identified up‐ and down‐regulated phosphoproteins have potential to serve as biomarkers for PAH and to provide new insights for therapeutic strategies.
Association of statin use and the risk of recurrent pulmonary embolism in real‐world Chinese population
Authors: Wang Lu , Shu Tingting , Wang Wuwan , Chen Huaqiao , Feng Panpan , Xiang Rui , Huang Wei
Published: July 2021

Background

Previous studies have suggested that statins exert protective effects against venous thromboembolism. However, few randomized studies have explicitly concentrated on patients with pulmonary embolism. Thus far, evidence of the effect of statins on the pulmonary embolism recurrence in China remains lacking.

Methods

A retrospective analysis was conducted utilizing our University database. Patients with an International Coding of Diseases‐defined diagnosis of pulmonary embolism from 1 January 2017 to 31 December 2019 were included. The patients were divided into two groups, namely, with statin or without statin treatment. Propensity score matching was applied to balance the covariates between the comparison groups. Univariate analysis and multivariable logistic regression were performed to analyze the association between statin use and pulmonary embolism recurrence.

Results

A total of 365 patients diagnosed with pulmonary embolism were included in the research. Pulmonary embolism recurrence accounted for 15.1% of the patients and was observed during the entire study period. In the initial population, no significant difference in recurrence was observed between the groups with and without statins treatment (statin 15.6% vs. non‐statin 14.9%, p = 0.860). After propensity score matching, multivariate logistic regression analysis revealed that the odds ratio of pulmonary embolism recurrence in the statin users was 0.489 (95% confidence interval 0.190–1.258, p = 0.138).

Conclusions

Our study provides no support for the use of statins as an adjunctive therapy in patients with pulmonary embolism at the initiated time of diagnosis or as a prophylactical plan when anticoagulation is discontinued attempting to reduce the risk of recurrence.
Risk factors for triatominae infestation in a municipality of Colombia
Authors: Parra-Henao Gabriel , Garzón-Jiménez Sandra P. , Bernal-Rosas Yuly , Olivera Mario J. , Salgado Marlon , Torres-García Orlando A.
Published: July 2021

Background:

Identifying risk factors for Triatominae infestation is essential for the development of vector control interventions.

Methods:

To determine the intra- and peridomiciliary risk factors associated with triatomine infestation, a cross-sectional analytical study was carried out with random cluster sampling in two stages, which included the identification of risk factors by survey and direct observation, as well as the search and capture of triatomines. The detection of trypanosomes in triatomines was carried out by observing the rectal content and then by conventional polymerase chain reaction (PCR).

Results:

In 21 of the 207 houses inspected, 13 specimens of R. colombiensis and 19 specimens of P. geniculatus were found. Entomological indices included: dispersion 36%, infestation 10%, infection 65%, colonization 4.7%, density 15%, and concentration 152%. An association was found between the presence of Triatominae and the existence of branches and fissures in the floors, as well as with the presence of accumulated objects and with knowledge about Chagas disease. The risk of having triatomines in urban homes is 5.7 times higher than the risk in rural areas [confidence interval (CI) 0.508–67.567]; 6.6 times in houses with cracked soil (CI 0.555–81.994), 6 times in houses located near caneys (CI 0.820–44.781), and 6.16 times with accumulated objects (CI 1.542–39.238).

Conclusion:

Chagas disease is a complex problem that requires control based on the vector’s elimination or surveillance, which implies identifying species and their distribution, generating alerts, knowledge, and awareness in the population. It is necessary to intensify surveillance activities for the event, especially in changing aspects of Chagas diseases’ transmission dynamics, such as urbanization and the type of housing associated with the vector’s presence.
Double heart – chronic large missed pseudoaneurysm of left ventricle
Authors: Maadarani Ossama , Bitar Zouheir , Elshabasy Ragab , Zaalouk Tamer , Mohsen Mohamad , Elzoueiry Mahmoud , Abdelfatah Mohamad , Elhabibi Mohamad , Gohar Mohamad
Published: July 2021

Myocardial infarction is considered the most common cause of left ventricular pseudoaneurysm. Large missed pseudoaneurysm of the left ventricle incidentally diagnosed and treated conservatively.
The Long-Term Effects of a Housing First Intervention on Primary Care and Non-Primary Care Physician Visits Among Homeless Adults with Mental Illness: A 7-Year RCT Follow-Up
Authors: Mejia-Lancheros Cilia , Lachaud James , To Matthew J. , Lee Patsy , Nisenbaum Rosane , O’Campo Patricia , Stergiopoulos Vicky , Hwang Stephen W.
Published: July 2021

Background:

Housing First (HF)-based interventions have been implemented in North America and beyond to help people exit homelessness. The effect of these interventions on access to primary and specialist care services is not well-defined. This study assesses the long-term effects of an HF intervention for homeless adults with mental illness on primary care physician (PCP) and non-primary care physician (non-PCP) visits.

Methods:

This is a secondary analysis of the At Home/Chez Soi study, a randomized trial of HF for homeless adults with mental illness in Toronto, Canada. High-need (HN) participants were randomized to HF with assertive community treatment (HF-ACT) or treatment as usual (TAU). Moderate needs (MN) participants were randomized to HF with intensive case management (HF-ICM) or TAU. The primary outcomes were the incidence and the number of visits to a PCP and non-PCP over 7-years post-randomization, compared to the 1-year pre-randomization.

Results:

Of 575 enrolled participants, 527 (80 HN and 347 MN) participants were included in the analyses. HN participants who received HF-ACT had a significant reduction in the number of visits to a PCP compared to TAU participants (ratio of rate ratios (RRR): 0.66, 95% CI: 0.48-0.93) and a significant reduction in the number of non-PCP visits compared with TAU participants (RRR: 0.64, 95% CI: 0.42-0.97) in the 7-years post-randomization compared to the 1-year pre-randomization. MN participants who received HF-ICM had a significant increase in incident visits to a PCP compared to TAU participants (RRR: 1.66, 95% CI: 1.10-2.50). No effect of HF-ICM was observed on the incidence or number of non-PCP visits.

Conclusion:

HF has differing effects on visits to PCPs and non-PCPs among homeless people with high and moderate needs for mental health supports. HF does not result in a consistent increase in PCP and non-PCP visits over a 7-year follow-up period. The At Home/Chez Soi study is registered with ISRCTN (ISRCTN, ISRCTN42520374).
Bijou: Engaging Young MSM in HIV Care Using a Mobile Health Strategy
Authors: Chenneville Tiffany , Drake Hunter , Gabbidon Kemesha , Rodriguez Carina , Hightow-Weidman Lisa
Published: July 2021

Young men who have sex with men (YMSM) living with HIV experience challenges with retention in care, which negatively affects viral suppression. To address this, researchers piloted Bijou, a program designed to provide health education through electronically delivered behavior and risk reduction modules. Participants were 29 YMSM aged 19-24 living with HIV from the southeastern US. Participants completed pre, post, and 3-month follow-up (3MFU) surveys assessing knowledge, intervention acceptability, satisfaction, self-efficacy, ehealth literacy, and usability. Findings revealed significant improvement in knowledge and e-health literacy from pre-test to post-test but lost significance at 3MFU. Self-efficacy scores did not show significant differences from pre-test to post-test or 3MFU. Participants who completed all modules considered Bijou usable and acceptable; however, many did not complete the program. Findings suggest a need for adaptations to promote knowledge retention, e-health literacy, engagement over time, and research with a larger, more representative sample.
Taming rock music in communist states: Politicisation of Western popular culture in East Europe and mainland China
Authors: Fürst Rudolf
Published: July 2021

A comparison of the former Eastern Bloc and China’s ways of dealing with the social implications of rock music as an alien cultural import from the West reveals significant analogies. The paper traces the process of politicisation of rock music and compares the two different cultural spaces by mapping each space’s state ideology, aesthetic traditions and identities, and discriminative political and economic tools used to marginalise rock. Here the term politicisation refers mainly to the polarisation between the communist regimes’ restrictive policies, and the attempts of the rock scenes to sustain their discriminating characteristics and relationship to protest. While in European communist states rock played a relevant subversive role, conversely, in China any ‘rocking’ of the state has largely been averted. The Chinese rock scene as an off-mainstream urban subculture has received less popular support than its counterpart in Europe and has also proved less politically significant. This comparative case study discusses the relationship between popular music and politics by tracing analogies and differences between the former Czechoslovakia, where the ideologisation and politicisation of rock reached the highest point in the Eastern Bloc, and contemporary China.
One Room Schoolhouse: A Novel Intervention for Inspired Academic Half-Day Learning in Distributed Campus Settings
Authors: Harms Sheila , Acai Anita , Bogie Bryce JM , McConnell Meghan M , McCutchen Ben , Fallen Robyn , Corey JoAnn , Snelgrove Natasha
Published: July 2021

Introduction:

Some studies on academic half days (AHDs) suggest that learning in this context is associated with a lack of educational engagement. This challenge may be amplified in distributed campus settings, where geographical disadvantages demand reliance on videoconferencing or considerable time spent travelling to in-person learning events. Concerns about the educational effectiveness of AHDs by learners within our distributed campus setting led to the development and evaluation of the One Room Schoolhouse (ORS), a unique, evidence-informed, community-based curriculum that partially replaced the AHD sessions delivered at the main campus. It was hypothesized that creating an AHD experience that was clinically reflective of the community in which residents practiced and where residents were given the autonomy to implement novel pedagogical elements would result in better test scores and improved learner satisfaction among ORS learners.

Methods:

The ORS was implemented at McMaster University’s Waterloo Regional Campus in 2017. Residents across training cohorts (N = 9) engaged in co-learning based on scenarios co-developed from clinical experiences within the region. The learning approach relied on multiple, evidence-informed pedagogical strategies. A multi-method approach was used to evaluate the ORS curriculum. Between-subject analyses of variance were used to compare scores on practice exams (COPE and PRITE), in-training assessment reports (ITARs), and objective structured clinical exams (OSCEs) between learners who took part in the ORS and learners at the main campus. A semi-structured focus group probing residents’ experiences with the ORS was analyzed using interpretive description.

Results:

ORS learners significantly outperformed learners at the main campus on the November OSCE ( p = .02), but not on the COPE, PRITE, ITARs, or September OSCE ( p’s < .05). Qualitative themes suggested advantages of the ORS in inspiring learning, engaging learners, and improving self-confidence in knowledge acquisition. These findings are aligned with the broader literature on learner agency, social development, and communities of practice.

Conclusion:

While the quantitative data only showed a significant difference between the 2 curricula on 1 measure (ie, the November OSCE), the qualitative findings offered an opportunity for educators to reimagine what medical education might consist of beyond the confines of a “traditional” AHD. Creating opportunities to enhance personal agency when acquiring knowledge, inspiring engagement about patient-related problems, and incorporating interdisciplinary learning through community engagement were critical pedagogical elements that were attributed to the success of the ORS.
The nonlocal parameter for three-dimensional nonlocal elasticity analyses of square graphene sheets: An exact buckling analysis
Authors: Naderi Abusaleh
Published: July 2021

This paper studies buckling problem of square nano-plates under uniform biaxial pressure through using three-dimensional nonlocal elasticity theory. Equations of stability are solved analytically for square nano-plates with simple supports using a Navier-type method. Critical buckling stress is presented for nano square plates with different thickness-length and nonlocal parameter-length ratios. The critical buckling stress is also reported using different local (classical) and nonlocal two-dimensional plate theories constructed essentially based on some simplifying assumptions. Comparison of the results of two-dimensional and three-dimensional theories for both local and nonlocal cases shows that the nonlocal two-dimensional plate theories are not as accurate as the local two-dimensional ones. This issue however reveals importance of the nonlocal three-dimensional solutions. Finally, through comparison of the numerical results with those obtained from molecular dynamic simulations, the value of the nonlocal parameter is calibrated for square graphene sheets. This parameter can be also used for the other nonlocal three-dimensional mechanical analyses of square graphene sheets to find accurate solutions.
Availability and accessibility of monoclonal antibodies in Bosnia and Herzegovina: Findings and implications
Authors: Tubic Biljana , Marković-Peković Vanda , Jungić Saša , Allocati Eleonora , Godman Brian
Published: July 2021

Background:

Monoclonal antibodies (mAbs) represent the most numerous and significant group of biotherapeutics. While mAbs have undoubtedly improved treatment for many chronic diseases, including inflammatory diseases, they are typically expensive for health care systems and patients. Consequently, access to mAbs has been a problem for many patients especially among Central and Eastern European (CEE) countries. However, biosimilars can potentially help with costs, although there are concerns with their effectiveness and safety. This includes biosimilars for long-acting insulin analogues.

Aim:

Assess the availability and use of biological medicines, including biosimilars within Bosnia and Herzegovina (B&H).

Methods:

Assess the availability of mAbs via the current lists of approved and accessed mAbs versus those licenced in Europe and the United States and their utilisation, as well as specifically insulin glargine and its biosimilars, within B&H.

Results:

The availability of the mAbs in B&H appears satisfactory, which is encouraging. However, current usage is limited to a few mAbs which is a concern for subsequent patient care especially with limited use of biosimilars to address issues of affordability. We also see limited use of biosimilar insulin glargine.

Conclusion

The limited use of mAbs including biosimilars needs to be addressed in B&H to improve the future care of patients within finite resources. We will monitor these developments.
Reappraising B. R. Ambedkar’s Thoughts of Inclusive Indian Nation
Authors: Debnath Kunal
Published: July 2021

Dr B. R. Ambedkar, one of the makers of the Indian Constitution, is known best as the emancipator of the untouchables. Ambedkar’s effort to make India as a nation through ‘breaking the internal differences’ is much debated and not widely recognized as he has still been confined only to his identity as a ‘liberating leader of the Dalits’. Ambedkar’s ideas—caste annihilation, securing rights to the depressed class, representation of the oppressed in political affairs, egalitarian economic arrangement, women’s rights and thoughts on democracy—all have the potential to be linked with his ideas of a nation, which is inclusive in nature.
Religious Pluralism Among the Navayana Buddhist Women: A Study in Mumbai Metropolitan Region, India
Authors: Sonowal C. J. , Ashok Mayuri
Published: July 2021

Dr B. R. Ambedkar adopted the policy of ‘religious conversion’ to provide social justice to the Mahars—an untouchable community in the state of Maharashtra. Nearly, three and a half million people accepted Navayana Buddhism on a single day under his leadership, denouncing Hindu gods and goddesses and vowed not to accept untouchable status imposed by the caste-Hindu population. Contrary to such a radical departure from Hinduism, there is evidence that a substantial chunk of the people still follows Hindu traditions and beliefs and practices, exhibiting a culture of religious pluralism. Based on a primary field study conducted among the Navayana Buddhist women in Mumbai Metropolitan Region, the article examines and explains the causes of such manifestation in the studied population’s religious life.
Trends in Leadership and Award Recognition Among Women in the American Society of Retina Specialists
Authors: Reeves Mary-Grace R. , Pasricha Malini Veerappan , Ludwig Cassie A. , Chandramohan Arthika , Azad Amee D. , Li Angela S. , Rosenblatt Tatiana R. , Sears Connie Martin , Kossler Andrea L. , Do Diana V. , Pan Carolyn K.
Published: July 2021

Purpose:

This work evaluates trends in achievement of women in the retina field, through an analysis of gender representation in the American Society of Retina Specialists (ASRS).

Methods:

This retrospective, longitudinal study spans 1983 to 2020. Historical data classified by male or female gender were collected from ASRS's overall membership, board of directors and officers, and recipients of the 4 society awards. The proportion of each benchmark held by women was compared with prior decades since the founding of ASRS using the Fisher’s exact test.

Results:

Women’s representation increased from 11% of ASRS members in 2007 to 19.7% in 2020. From 2010 to 2019, women received a higher proportion of society awards (21.1%) compared with membership prior to the start of that decade. In 2020, women were proportionally well represented in board of director positions (21.9%) and held a significantly higher proportion of board positions than in the period 1983 to 1989 ( P = .02). From 1983 to 2020, women held 4.3% (1 of 23) of presidencies.

Conclusions:

Although the number of women in retina is increasing, women remain underrepresented in the leadership of ASRS. Interventions to increase exposure to female mentorship and improve childcare benefits are warranted to engage female ophthalmology trainees in retina and ultimately society leadership.
Outcomes of lacrimal probing surgery as the first option in the treatment of congenital dacryocystocele
Authors: Akpolat Cetin , Sendul Selam Yekta , Unal Ebru Turkoglu , Karatas Egemen , Ucgul Atilgan Cemile , Demir Mehmet
Published: July 2021

Purpose:

To determine the demographic and clinical characteristics of newborn patients who underwent lacrimal probing surgical intervention with or without the marsupialization of intranasal cysts as the primary management for dacryocystocele treatment.

Methods:

Data from the medical charts of 350 infants who underwent lacrimal probing surgery due to nasolacrimal duct obstruction were reviewed retrospectively. Ten newborn patients with a naive diagnosis of congenital dacryocystocele were included in the study. Congenital dacryocystocele diagnosis was based on a triad of swelling in the inner canthal region, a bluish appearance, and epiphora. Lacrimal probing surgery accompanied by nasal endoscopy was planned for all patients as the first treatment option.

Results:

The mean age of the patients was 24.90 ± 7.15 days, with a range of 6–85 days. A total of 10 patients were included, comprising seven females and three males. The mean postoperative follow-up period was 38.7 ± 24.41 months. Five patients had left, four patients had right, and one patient had bilateral dacryocystocele. Seven eyes of the six patients had uncomplicated dacryocystocele, while the remaining patients had dacryocystocele with complications of dacryocystitis and/or preseptal cellulitis. All patients had intranasal cysts. All patients underwent one session of lacrimal probing surgery under general anesthesia; all with successful outcomes. Four patients with additional dacryocystocele-associated complications underwent combined intranasal marsupialization of the cyst wall.

Discussion:

Lacrimal probing surgery ± intranasal marsupialization of the cyst wall as a first treatment option can be effective for both congenital dacryocystocele and/or congenital dacryocystocele plus associated complications and provide complete resolution of dacryocystocele-related symptoms.
Conformal Fabrication of an Electrospun Nanofiber Mat on a 3D Ear Cartilage-Shaped Hydrogel Collector Based on Hydrogel-Assisted Electrospinning
Authors: Song Jin Yeong , Ryu Hyun Il , Lee Jeong Myeong , Bae Seong Hwan , Lee Jae Woo , Yi Changryul Claud , Park Sang Min
Published: July 2021

Electrospinning is a common and versatile process to produce nanofibers and deposit them on a collector as a two-dimensional nanofiber mat or a three-dimensional (3D) macroscopic arrangement. However, 3D electroconductive collectors with complex geometries, including protruded, curved, and recessed regions, generally caused hampering of a conformal deposition and incomplete covering of electrospun nanofibers. In this study, we suggested a conformal fabrication of an electrospun nanofiber mat on a 3D ear cartilage-shaped hydrogel collector based on hydrogel-assisted electrospinning. To relieve the influence of the complex geometries, we flattened the protruded parts of the 3D ear cartilage-shaped hydrogel collector by exploiting the flexibility of the hydrogel. We found that the suggested fabrication technique could significantly decrease an unevenly focused electric field, caused by the complex geometries of the 3D collector, by alleviating the standard deviation by more than 70% through numerical simulation. Furthermore, it was experimentally confirmed that an electrospun nanofiber mat conformally covered the flattened hydrogel collector with a uniform thickness, which was not achieved with the original hydrogel collector. Given that this study established the conformal electrospinning technique on 3D electroconductive collectors, it will contribute to various studies related to electrospinning, including tissue engineering, drug/cell delivery, environmental filter, and clothing.
Knowledge, perceptions and effects of Ebola virus disease outbreak on the pig value chain in the agro-pastoralist district of Luwero, Central Uganda
Authors: Birungi Doreen , Tumwine Gabriel , Kato Charles Drago , Ssekamatte Tonny , Ocaido Michael , Majalija Samuel
Published: July 2021

Background

Ebola Virus Disease (EVD) outbreaks have a significant impact on the health and wellbeing, and livelihoods of communities. EVD response interventions particularly affect the food value chain, and income security of pig farmers in agro-pastoral communities. Despite the enormous effort of EVD response interventions, there is paucity of information towards EVD among those involved in the pig value chain, as well as the effect of EVD outbreaks on the pig value chain. This study therefore, assessed the knowledge, perceptions on the occurrence of Ebola and its effects on the pig value chain in the agro-pastoral district of Luweero, Central Uganda.

Methods

A cross sectional study was conducted in two parishes of Ssambwe and Ngalonkulu, Luwero district. A total of 229 respondents were included in the study. Structured questionnaires, key informant interviews and focus group discussions were conducted to collect data. Quantitative data was analysed using SPSS version 22 while qualitative data was analysed using thematic content analysis.

Results

Of the 229 respondents, 95.6% could recall the occurrence of the last EVD outbreak in their locality. About 24.5% associated EVD with touching pigs or eating pork. Regarding knowledge, 194 (84.7%) correctly associated EVD with handling Ebola infected persons, 191 (83.4%) with migration of people from endemic areas, 148 (64.9%) eating monkey meat, 127 (55.5%) with eating bats, and 198 (64.9%) with conducting public meetings where there is an Ebola infected person. Out of 142 farmers, 55 (38.7%) believed that Ebola outbreaks affected demand and sale of pigs. The EVD outbreak significantly led to a reduction in the average number of pigs sold (P = 0.001), the average number of pigs bought by traders (P = 0.04), and the number of pigs sold/ slaughtered by butcher men at pork eating places (P = 0.03).

Conclusion

This study showed that EVD outbreak negatively affected the pig value chain i.e., the demand and supply of pigs and pork. Therefore, there is need to sensitize the stakeholders in the pig value chain on EVD in order to minimize the negative economic impacts associated with EVD outbreaks.
Aggregation-and-Attention Network for brain tumor segmentation
Authors: Lin Chih-Wei , Hong Yu , Liu Jinfu
Published: July 2021

Background

Glioma is a malignant brain tumor; its location is complex and is difficult to remove surgically. To diagnosis the brain tumor, doctors can precisely diagnose and localize the disease using medical images. However, the computer-assisted diagnosis for the brain tumor diagnosis is still the problem because the rough segmentation of the brain tumor makes the internal grade of the tumor incorrect.

Methods

In this paper, we proposed an Aggregation-and-Attention Network for brain tumor segmentation. The proposed network takes the U-Net as the backbone, aggregates multi-scale semantic information, and focuses on crucial information to perform brain tumor segmentation. To this end, we proposed an enhanced down-sampling module and Up-Sampling Layer to compensate for the information loss. The multi-scale connection module is to construct the multi-receptive semantic fusion between encoder and decoder. Furthermore, we designed a dual-attention fusion module that can extract and enhance the spatial relationship of magnetic resonance imaging and applied the strategy of deep supervision in different parts of the proposed network.

Results

Experimental results show that the performance of the proposed framework is the best on the BraTS2020 dataset, compared with the-state-of-art networks. The performance of the proposed framework surpasses all the comparison networks, and its average accuracies of the four indexes are 0.860, 0.885, 0.932, and 1.2325, respectively.

Conclusions

The framework and modules of the proposed framework are scientific and practical, which can extract and aggregate useful semantic information and enhance the ability of glioma segmentation.
Effects of a novel mobile health intervention compared to a multi-component behaviour changing program on body mass index, physical capacities and stress parameters in adolescents with obesity: a randomized controlled trial
Authors: Stasinaki A. , Büchter D. , Shih C.-H. I. , Heldt K. , Güsewell S. , Brogle B. , Farpour-Lambert N. , Kowatsch T. , l’Allemand D.
Published: July 2021

Background

Less than 2% of overweight children and adolescents in Switzerland can participate in multi-component behaviour changing interventions (BCI), due to costs and lack of time. Stress often hinders positive health outcomes in youth with obesity. Digital health interventions, with fewer on-site visits, promise health care access in remote regions; however, evidence for their effectiveness is scarce.

Methods

This randomized controlled not blinded trial (1:1) was conducted in a childhood obesity center in Switzerland. Forty-one youth aged 10–18 years with body mass index (BMI) > P.90 with risk factors or co-morbidities or BMI > P.97 were recruited. During 5.5 months, the PathMate2 group (PM) received daily conversational agent counselling via mobile app, combined with standardized counselling (4 on-site visits). Controls (CON) participated in a BCI (7 on-site visits). We compared the outcomes of both groups after 5.5 (T1) and 12 (T2) months. Primary outcome was reduction in BMI-SDS (BMI standard deviation score: BMI adjusted for age and sex). Secondary outcomes were changes in body fat and muscle mass (bioelectrical impedance analysis), waist-to-height ratio, physical capacities (modified Dordel-Koch-Test), blood pressure and pulse. Additionally, we hypothesized that less stressed children would lose more weight. Thus, children performed biofeedback relaxation exercises while stress parameters (plasma cortisol, stress questionnaires) were evaluated.

Results

At intervention start median BMI-SDS of all patients (18 PM, 13 CON) was 2.61 (obesity > + 2SD). BMI-SDS decreased significantly in CON at T1, but not at T2, and did not decrease in PM during the study. Muscle mass, strength and agility improved significantly in both groups at T2; only PM reduced significantly their body fat at T1 and T2. Average daily PM app usage rate was 71.5%. Cortisol serum levels decreased significantly after biofeedback but with no association between stress parameters and BMI-SDS. No side effects were observed.

Conclusions

Equally to BCI, PathMate2 intervention resulted in significant and lasting improvements of physical capacities and body composition, but not in sustained BMI-SDS decrease. This youth-appealing mobile health intervention provides an interesting approach for youth with obesity who have limited access to health care. Biofeedback reduces acute stress and could be an innovative adjunct to usual care.
Classification of COPD patients and compliance to recommended treatment in Greece according to GOLD 2017 report: the RELICO study
Authors: Tzanakis Nikolaos , Koulouris Nikolaos , Dimakou Katerina , Gourgoulianis Konstantinos , Kosmas Epameinondas , Chasapidou Georgia , Konstantinidis Athanasios , Kyriakopoulos Christos , Kontakiotis Theodoros , Rapti Aggeliki , Gaga Mina , Kalafatakis Konstantinos , Kostikas Konstantinos
Published: July 2021

Background

Chronic obstructive pulmonary disease (COPD) is a multifactorial clinical condition, characterized by chronic progressive (or worsening) respiratory symptoms, structural pulmonary abnormalities, and impaired lung function, and is often accompanied by multiple, clinically significant comorbid disorders. In 2017, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) issued a new report on COPD prevention, diagnosis and management, aiming at personalizing the maintenance therapeutic approach of the stable disease, based on the patients’ symptoms and history of exacerbations (ABCD assessment approach). Our objective was to evaluate the implementation of GOLD suggestions in everyday clinical practice in Greece.

Methods

This was a cross-sectional observational study. Sixty-five different variables (demographics, vital sign measurements, COPD-related medical history parameters, comorbidities, vaccination data, COPD severity based on spirometry measurements, COPD stage based on the ABCD assessment approach, COPD treatments) were collected from 3615 nation-wide COPD patients (Greece).

Results

The mean age at the time of initial COPD diagnosis was 63.8 (± 10.2). Almost 60% of the subjects were classified into group B, while the remaining patients were falling into groups A (18%) and D (21%), and only a small minority of patients belonged to Group C, according to the ABCD assessment approach. The compliance of respiratory physicians to the GOLD 2017 therapeutic suggestions is problematic, especially when it comes to COPD patients belonging to Group A.

Conclusion

Our data provide valuable information regarding the demographic and medical profile of COPD patients in Greece, the domains which the revised ABCD assessment approach may show some clinical significance on, and the necessity for medical practitioners dealing with COPD patients to adhere closer to international recommendations for the proper management of the disease.