bluuebunny/crossref_metadata_2025 huggingface dataset:
Ekstraksi Ciri Bentuk pada Citra Bergerak Menggunakan Teknik Batas Tepi
Authors: Supriyatin Wahyu
Published: July 2022

Computer vision sebagai pengembangan dari pengolahan citra membutuhkan informasi yang sesuai. Citra dua dimensi atau tiga dimensi yang akan digunakan dalam proses pengolahan citra memerlukan perbaikan sehingga dapat menampilkan ciri atau informasi yang dibutuhkan. Ekstraksi ciri merupakan salah satu tahapan preprocessing citra. Ekstraksi ciri dapat berupa bentuk, warna atau tekstur. Penelitian ini membahas tentang ektraksi ciri bentuk menggunakan teknik batas (boundary-based). Ekstraksi ciri bentuk digunakan untuk mengenali bentuk objek dari citra tiga dimensi (video) yang digunakan. Teknik batas dalam penelitian ini menggunakan edge detection prewitt. Pengujian menggunakan tiga video sebagai objek yang diperoleh dari library Matlab. Pengujian dilakukan dengan tools Simulink Matlab. Hasil pengujian ekstraksi ciri bentuk dengan deteksi tepi prewitt berhasil menampilkan objek yang ada dalam video. Objek berhasil dikenali serta background yang ada dalam video juga berhasil terdeteksi. Prewitt menghasilkan tepi yang jelas dan halus pada objek, sehingga ekstraksi ciri bentuk yang dilakukan dapat mengenali objek seperti aslinya.
Kamus Digital Tanaman Obat Menggunakan Algoritme Knuth Morris Pratt Berbasis Mobile
Authors: Qurania Arie , - Triastinurmiatiningsih , Candra Erika
Published: July 2022

Digital dictionary of medicinal plants a collection of applications a collection of names of medicinal plants. This application was developed to make it easier for users to access the use of medicinal plants based on keywords, names of common diseases such as asthma, diarrhea, fever, headache, diabetes, and so on. The obstacle in using the digital dictionary application of medicinal plants is that it is difficult to find exact information on drug searches, because the vocabulary in producing several other items is not necessarily the same as what is being sought. This study uses the Knuth Morris Pratt (KMP) algorithm search technique on a digital dictionary of medicinal plants by matching keywords as input with strings between text and patterns. This study aims to develop previous research on a digital dictionary of medicinal plants using a mobile-based Rocchio algorithm that searches medicinal plant data by querying proximity in a database that has weaknesses in words that have the same meaning with different words, using another search technique, namely KMP. is expected to get optimal results on search results based on the keyword name of the disease. The test results with 30 keywords on 640 medicinal plant data resulted in a precision value of 92.4, accuracy and recall of 100%.
Virtual Tour Campus Sebagai Media Promosi di Masa Pandemik Covid-19
Authors: Karlitasari Lita , Situmorang Boldson Herdianto , Putra Agung Prajuhana , Sabrina Amalia , Randika Diva
Published: July 2022

The use of Virtual Tours is now widely used to introduce infrastructure facilities owned by a campus. For almost a year, the COVID-19 pandemic has made prospective students and college students hesitant to continue their studies. This raises concerns if you come directly to campus to see all the facilities in it. The purpose of this research is to create a virtual campus tour application as an alternative media promotion during the COVID-19 pandemic. This study uses the Multimedia Development Life Cycle (MDLC) method using augmented reality. The result of this research is an application in the form of a virtual game, where before exploring the study programs, the user will be asked to have the appropriate character, then with the help of controlling the joystick from the keyboard, the user can enter the rooms and the information in it, either in the form of direct templates. or use the barcode to go directly to the information in it. Thus, in addition to users becoming more familiar with the Computer Science Study Program environment and the infrastructure in it, it is also an inspirational tool, that to study or create applications it can be done if you enter as a student.
Detection and Classification of DDos Attack on Software Defined Network
Authors: Anggraeni Irma , Akhmad Dinar Munggaran
Published: July 2022

Software-Defined Networking (SDN) is a new network paradigm that changes network architecture. However, it turns out that the SDN network also has several issues, one of which is security. The higher the traffic on the network, the higher the possibility of security threats that will occur. Therefore, it is necessary to detect attacks that might occur on this SDN network. This study will detect attacks on the SDN network with the stages carried out, namely the process of building an SDN architecture using a mininet emulator, then network simulation according to the topology, retrieval of traffic data using wireshark and performing data analysis using the Weka application on the NSL KDD dataset. The results of this research found that a DDos attack a ping of death is an attack that sends messages continuously to the recipient, causing the computer to crash, then analysis of attack classification data is carried out using a dataset to compare machine learning algorithms that have high accuracy was Random Forests. The targeted output in this research is published in the Journal of Computing.
Application of The Fuzzy Promethee Method in Selecting Farmer Groups Verification for Candidates for Receiving Grants Regional Revenues And Expenditures Budget
Authors: Rachman Benny , Hardhienata Soewarto , Maryana Sufiatul
Published: July 2022

The Bogor Regency Department of Fisheries and Livestock, in charge of the Breeding and Livestock Cultivation Section, has a work program to assist farmer groups, especially livestock, in acquiring aid funds from the government sourced from the Bogor Regency Regional Revenues and Expenditures Budget (APBD). As a result, the government allocates aid fundsfrom the Regional Revenues and Expenditures Budges (APBD) budget source to aid the community in managing livestock. Based on this, research will be conducted and methods used to determine which livestock farmer groups are eligible for government assistance will be implemented.A Decision Support System (DSS) will be used as a tool to recommend which farmer groups deserve assistance based on predetermined assessment criteria. By using the service, you will be able to provide a more accurate and objective evaluation. Because of its capacity to determine criteria values that contain uncertainty and select the best alternative based on these rankings and alternatives, the Fuzzy-PROMETHEE approach was chosen for handlingmulti criteria issues.
Imaginaries of Machine Vision. A Short History.
Authors: Schröter Jens
Published: July 2022

The historical development of the technologies that ultimately led to the field of ‘machine vision’began in the 1960s. As is always the case with emerging technologies, imaginaries ofpotential future usages (and dangers) of the potential new technologies emerged too. This paper/article analyzes the intertwined histories of machine vision technologies and their correspondingimaginaries, by focusing on some exemplary configurations. These analyses revealhow machine vision was imagined, to which uses it should be put and what dangers were seento be lurking in it. The paper focuses, first, on methodological considerations, on how to reconstructthe intertwining genealogies of technologies and their imaginary representations. Secondly,it examines three examples. The first example is the famous point-of-view shots ofHAL9000 in Stanley Kubricks’ 2001: A Space Odyssey (1968). The second example is thepoint-of-view of the antagonist in Westworld (1973), played by Yul Brynner. These shots havea ‘pixilated’ look that stages machine vision in a way that connects it to the slowly emergingdigital image aesthetics. The machine POV in The Terminator (1984) is the last example. Thepaper ends with a conclusion and a short analysis of Kazuo Ishiguro’s novel Klara and the Sun(2021).
Methane Single Cell Protein: Potential to Secure a Global Protein Supply Against Catastrophic Food Shocks
Authors: García Martínez Juan B. , Pearce Joshua M. , Throup James , Cates Jacob , Lackner Maximilian , Denkenberger David C.
Published: July 2022

Global catastrophes such as a supervolcanic eruption, asteroid impact, or nuclear winter could cause global agricultural collapse due to reduced sunlight reaching the Earth’s surface. The human civilization’s food production system is unprepared to respond to such events, but methane single cell protein (SCP) could be a key part of the solution. Current preparedness centers around food stockpiling, an excessively expensive solution given that an abrupt sunlight reduction scenario (ASRS) could hamper conventional agriculture for 5–10 years. Instead, it is more cost-effective to consider resilient food production techniques requiring little to no sunlight. This study analyses the potential of SCP produced from methane (natural gas and biogas) as a resilient food source for global catastrophic food shocks from ASRS. The following are quantified: global production potential of methane SCP, capital costs, material and energy requirements, ramp-up rates, and retail prices. In addition, potential bottlenecks for fast deployment are considered. While providing a more valuable, protein-rich product than its alternatives, the production capacity could be slower to ramp up. Based on 24/7 construction of facilities, 7%–11% of the global protein requirements could be fulfilled at the end of the first year. Despite significant remaining uncertainties, methane SCP shows significant potential to prevent global protein starvation during an ASRS at an affordable price—US$3–5/kg dry.
Researching progress on bio-reactive electrogenic materials with electrophysiological activity for enhanced bone regeneration
Authors: Dong Shaojie , Zhang Yuwei , Mei Yukun , Zhang Yifei , Hao Yaqi , Liang Beilei , Dong Weijiang , Zou Rui , Niu Lin
Published: July 2022

Bone tissues are dynamically reconstructed during the entire life cycle phase, which is an exquisitely regulated process controlled by intracellular and intercellular signals transmitted through physicochemical and biochemical stimulation. Recently, the role of electrical activity in promoting bone regeneration has attracted great attention, making the design, fabrication, and selection of bioelectric bio-reactive materials a focus. Under specific conditions, piezoelectric, photoelectric, magnetoelectric, acoustoelectric, and thermoelectric materials can generate bioelectric signals similar to those of natural tissues and stimulate osteogenesis-related signaling pathways to enhance the regeneration of bone defects, which can be used for designing novel smart biological materials for engineering tissue regeneration. However, literature summarizing studies relevant to bioelectric materials for bone regeneration is rare to our knowledge. Consequently, this review is mainly focused on the biological mechanism of electrical stimulation in the regeneration of bone defects, the current state and future prospects of piezoelectric materials, and other bioelectric active materials suitable for bone tissue engineering in recent studies, aiming to provide a theoretical basis for novel clinical treatment strategies for bone defects.
Fabrication of “electroactive cells” using bio-inspired polydopamine-derived carbon nanoparticles for manipulation of cells with electrical stimulation
Authors: Li Fang-Yi , Chung Yi-Chang
Published: July 2022

In this study, we report some bio-inspired carbon nanoparticles (CNPs) that exhibit high fluorescence quantum yields, good conductivity, excellent dispersion in aqueous solution, high cell-uptake efficiency, and no cytotoxicity as well. We were inspired by mussels’ adhesive components to synthesize polydopamine nanoparticles and then use a carbonization process to prepare fluorescent CNPs. Using some surfactants, we could control the sizes of CNPs and increase their dispersion in water. Fluorescence spectroscopy confirmed the excitation of CNPs at 360 nm and emission of blue light with a 400–450 nm wavelength. High quantum yields of greater than 20% were also measured. Transmission electron microscopy proved that the addition of surfactants could shrink particles to several nanometers in size. The fluorescent and conductive CNPs were applied to stain L929 fibroblast cells in vitro, finding no harmful effects on cells. Due to the polydopamine-derived CNPs’ good electrical, fluorescent, and biocompatible response, we designed a platform to manipulate the cells after endocytosis of conductive CNPs to observe the effects of electrical stimulation on cell attachment, cell growth, and cell death. The nanoparticles endocytosed by cells seemed more easily attracted to the electric field, leading to enhanced cell attachment and growth. Therefore, CNP uptake can increase the attachment of cells onto a conductive plate electrode in a short time (within 10 min at 4°C). When the source of the electric field was changed to rod electrodes in the medium, cells that had been pre-adsorbed onto a non-conductive plate were desorbed from the plate and destroyed. Therefore, addition of CNPs during cell incubation can allow control of cell growth and death via manipulation of electric fields.
Barriers to Uptake of Open-Source Automated Insulin Delivery Systems: Analysis of Socioeconomic Factors and Perceived Challenges of Caregivers of Children and Adolescents With Type 1 Diabetes From the OPEN Survey
Authors: Huhndt Antonia , Chen Yanbing , O’Donnell Shane , Cooper Drew , Ballhausen Hanne , Gajewska Katarzyna A. , Froment Timothée , Wäldchen Mandy , Lewis Dana M. , Raile Klemens , Skinner Timothy C. , Braune Katarina
Published: July 2022

Background

As a treatment option for people living with diabetes, automated insulin delivery (AID) systems are becoming increasingly popular. The #WeAreNotWaiting community plays a crucial role in the provision and distribution of open-source AID technology. However, while a large percentage of children were early adopters of open-source AID, there are regional differences in adoption, which has prompted an investigation into the barriers perceived by caregivers of children with diabetes to creating open-source systems.

Methods

This is a retrospective, cross-sectional and multinational study conducted with caregivers of children and adolescents with diabetes, distributed across the online #WeAreNotWaiting online peer-support groups. Participants—specifically caregivers of children not using AID—responded to a web-based questionnaire concerning their perceived barriers to building and maintaining an open-source AID system.

Results

56 caregivers of children with diabetes, who were not using open-source AID at the time of data collection responded to the questionnaire. Respondents indicated that their major perceived barriers to building an open-source AID system were their limited technical skills (50%), a lack of support by medical professionals (39%), and therefore the concern with not being able to maintain an AID system (43%). However, barriers relating to confidence in open-source technologies/unapproved products and fear of digital technology taking control of diabetes were not perceived as significant enough to prevent non-users from initiating the use of an open-source AID system.

Conclusions

The results of this study elucidate some of the perceived barriers to uptake of open-source AID experienced by caregivers of children with diabetes. Reducing these barriers may improve the uptake of open-source AID technology for children and adolescents with diabetes. With the continuous development and wider dissemination of educational resources and guidance—for both aspiring users and their healthcare professionals—the adoption of open-source AID systems could be improved.
Miro proteins and their role in mitochondrial transfer in cancer and beyond
Authors: Nahacka Zuzana , Novak Jaromir , Zobalova Renata , Neuzil Jiri
Published: July 2022

Mitochondria are organelles essential for tumor cell proliferation and metastasis. Although their main cellular function, generation of energy in the form of ATP is dispensable for cancer cells, their capability to drive their adaptation to stress originating from tumor microenvironment makes them a plausible therapeutic target. Recent research has revealed that cancer cells with damaged oxidative phosphorylation import healthy (functional) mitochondria from surrounding stromal cells to drive pyrimidine synthesis and cell proliferation. Furthermore, it has been shown that energetically competent mitochondria are fundamental for tumor cell migration, invasion and metastasis. The spatial positioning and transport of mitochondria involves Miro proteins from a subfamily of small GTPases, localized in outer mitochondrial membrane. Miro proteins are involved in the structure of the MICOS complex, connecting outer and inner-mitochondrial membrane; in mitochondria-ER communication; Ca2+ metabolism; and in the recycling of damaged organelles via mitophagy. The most important role of Miro is regulation of mitochondrial movement and distribution within (and between) cells, acting as an adaptor linking organelles to cytoskeleton-associated motor proteins. In this review, we discuss the function of Miro proteins in various modes of intercellular mitochondrial transfer, emphasizing the structure and dynamics of tunneling nanotubes, the most common transfer modality. We summarize the evidence for and propose possible roles of Miro proteins in nanotube-mediated transfer as well as in cancer cell migration and metastasis, both processes being tightly connected to cytoskeleton-driven mitochondrial movement and positioning.
Candida species and selected behavioral factors co-associated with severe early childhood caries: Case-control study
Authors: Cvanova Michaela , Ruzicka Filip , Kukletova Martina , Lipovy Bretislav , Gachova Daniela , Izakovicova Holla Lydie , Danek Zdenek , Hola Veronika , Bartosova Michaela , Jarkovsky Jiri , Dusek Ladislav , Borilova Linhartova Petra
Published: July 2022

Severe Early Childhood Caries (sECC) is a multifactorial disease associated with the occurrence of specific oral microorganisms and other environmental, behavioral, and genetic factors. This study aimed to construct a multivariable model including the occurrence ofCandidaspp. and selected behavioral factors (length of breastfeeding, serving sweet beverages and beginning of brushing child’s teeth) to determine their relationships to the occurrence of sECC.

In this case-control study 164 children with sECC and 147 children without dental caries were included. MALDI-TOF MS and multiplex qPCR were used to identifyCandidaspp. and selected bacteria in dental plaque samples, respectively. A questionnaire on oral hygiene, diet, and children’s health was filled in by the parents.

The constructed multivariable logistic regression model showed an independent influence of the microbial and behavioral factors in sECC etiopathogenesis. The occurrence ofC. albicansandC. dubliniensiswas associated with higher odds of sECC development (odds ratio, OR: 9.62 and 16.93, respectively), together with breastfeeding of 6 months or less (OR: 2.71), exposure to sweet beverages (OR: 3.77), and starting to brush child’s teeth after the 12thmonth of age (OR: 4.10), all statistically significant (p< 0.01).

Considering the high occurrence ofC. albicansandC. dubliniensisin dental plaque in children with sECC, we propose them as “keystone pathogens” and risk factors for sECC. The models showed that presence of specific species ofCandidain dental plaque may be a better descriptor of sECC than the mentioned behavioral factors.
Transcriptional response to VZV infection is modulated by RNA polymerase III in lung epithelial cell lines
Authors: Doratt Brianna M. , Vance Elizabeth , Malherbe Delphine C. , Ebbert Mark T.W. , Messaoudi Ilhem
Published: July 2022

Ancestral RNA polymerase III (Pol III) is a multi-subunit polymerase responsible for transcription of short non-coding RNA, such as double-stranded short interspersed nuclear elements (SINEs). Although SINE ncRNAs are generally transcriptionally repressed, they can be induced in response to viral infections and can stimulate immune signaling pathways. Indeed, mutations in RNA Pol III have been associated with poor antiviral interferon response following infection with varicella zoster virus (VZV). In this study, we probed the role of Pol III transcripts in the detection and initial immune response to VZV by characterizing the transcriptional response following VZV infection of wild type A549 lung epithelial cells as well as A549 cells lacking specific RNA sensors MAVS and TLR3, or interferon-stimulated genes RNase L and PKR in presence or absence of functional RNA Pol III. Multiple components of the antiviral sensing and interferon signaling pathways were involved in restricting VZV replication in lung epithelial cells thus suggesting an innate defense system with built-in redundancy. In addition, RNA Pol III silencing altered the antiviral transcriptional program indicating that it plays an essential role in the sensing of VZV infection.
Prognostic value of the PDW/HDL-C ratio in patients with chest pain symptoms and coronary artery calcification
Authors: Qiu Ya-Jing , Luo Jun-Yi , Luo Fan , Tian Xin-Xin , Zeng Lu , Zhang Zhuo-Ran , Li Xiao-Mei , Yang Yi-Ning
Published: July 2022

Background

Platelet-related parameters and HDL-C have been regarded as reliable and alternative markers of coronary heart disease (CHD) and the independent predictors of cardiovascular outcomes. PDW is a simple platelet index, which increases during platelet activation. Whether the PDW/HDL-C ratio predicts major adverse cardiovascular and cerebrovascular events (MACCEs) in patients who complained of chest pain and confirmed coronary artery calcification remains to be investigated. This study aimed to investigate the prognostic value of the PDW/HDL-C ratio in patients with chest pain symptoms and coronary artery calcification.

Methods

A total of 5,647 patients with chest pain who underwent coronary computer tomography angiography (CTA) were enrolled in this study. Patients were divided into two groups according to their PDW/HDL-C ratio or whether the MACCE occurs. The primary outcomes were new-onset MACCEs, defined as the composite of all-cause death, non-fatal MI, non-fatal stroke, revascularization, malignant arrhythmia, and severe heart failure.

Results

All patients had varying degrees of coronary calcification, with a mean CACS of 97.60 (22.60, 942.75), and the level of CACS in the MACCEs group was significantly higher than that in non-MACCE (P<0.001). During the 89-month follow-up, 304 (5.38%) MACCEs were recorded. The incidence of MACCEs was significantly higher in patients with the PDW/HDL-C ratio > 13.33. The K–M survival curves showed that patients in the high PDW/HDL-C ratio group had significantly lower survival rates than patients in the low PDW/HDL-C ratio group (log-rank test: P < 0.001). Multivariate Cox hazard regression analysis reveals that the PDW/HDL ratio was an independent predictor of MACCEs (HR: 1.604, 95% CI: 1.263–2.035; P < 0.001). Cox regression analysis showed that participants with a lower PDW/HDL-C ratio had a higher risk of MACCEs than those in the higher ratio group. The incidence of MACCEs was also more common in the PDW/HDL-C ratio > 13.33 group among different severities of coronary artery calcification. Furthermore, adding the PDW/HDL-C ratio to the traditional prognostic model for MACCEs improved C-statistic (P < 0.001), the NRI value (11.3% improvement, 95% CI: 0.018–0.196, P = 0.01), and the IDI value (0.7% improvement, 95% CI: 0.003–0.010, P < 0.001).

Conclusion

The higher PDW/HDL-C ratio was independently associated with the increasing risk of MACCEs in patients with chest pain symptoms and coronary artery calcification. In patients with moderate calcification, mild coronary artery stenosis, and CAD verified by CTA, the incidence of MACCEs increased significantly in the PDW/HDL-C ratio > 13.33 group. Adding the PDW/HDL-C ratio to the traditional model provided had an incremental prognostic value for MACCEs.
Research Progress of Myocardial Fibrosis and Atrial Fibrillation
Authors: Li Guangling , Yang Jing , Zhang Demei , Wang Xiaomei , Han Jingjing , Guo Xueya
Published: July 2022

With the aging population and the increasing incidence of basic illnesses such as hypertension and diabetes (DM), the incidence of atrial fibrillation (AF) has increased significantly. AF is the most common arrhythmia in clinical practice, which can cause heart failure (HF) and ischemic stroke (IS), increasing disability and mortality. Current studies point out that myocardial fibrosis (MF) is one of the most critical substrates for the occurrence and maintenance of AF. Although myocardial biopsy is the gold standard for evaluating MF, it is rarely used in clinical practice because it is an invasive procedure. In addition, serological indicators and imaging methods have also been used to evaluate MF. Nevertheless, the accuracy of serological markers in evaluating MF is controversial. This review focuses on the pathogenesis of MF, serological evaluation, imaging evaluation, and anti-fibrosis treatment to discuss the existing problems and provide new ideas for MF and AF evaluation and treatment.
Quantitative analysis of heart rate variability parameter and mental stress index
Authors: Luo Jiasai , Zhang Guo , Su Yiwei , Lu Yi , Pang Yu , Wang Yuanfa , Wang Huiqian , Cui Kunfeng , Jiang Yuhao , Zhong Lisha , Huang Zhiwei
Published: July 2022

Background

Cardiovascular disease not only occurs in the elderly but also tends to become a common social health problem. Considering the fast pace of modern life, quantified heart rate variability (HRV) indicators combined with the convenience of wearable devices are of great significance for intelligent telemedicine. To quantify the changes in human mental state, this article proposes an improved differential threshold algorithm for R-wave detection and recognition of electrocardiogram (ECG) signals.

Methods

HRV is a specific quantitative indicator of autonomic nerve regulation of the heart. The recognition rate is increased by improving the starting position of R wave and the time-window function of the traditional differential threshold method. The experimental platform is a wearable sign monitoring system constructed based on body area networks (BAN) technology. Analytic hierarchy process (AHP) is used to construct the mental stress assessment model, the weight judgment matrix is constructed according to the influence degree of HRV analysis parameters on mental stress, and the consistency check is carried out to obtain the weight value of the corresponding HRV analysis parameters.

Results

Experimental results show that the recognition rate of R wave of real-time 5 min ECG data collected by this algorithm is >99%. The comprehensive index of HRV based on weight matrix can greatly reduce the deviation caused by the measurement error of each parameter. Compared with traditional characteristic wave recognition algorithms, the proposed algorithm simplifies the process, has high real-time performance, and is suitable for wearable analysis devices with low-configuration requirements.

Conclusion

Our algorithm can describe the mental stress of the body quantitatively and meet the requirements of application demonstration.
Efficacy and safety of Puerarin injection on acute heart failure: A systematic review and meta-analysis
Authors: Li Zunjiang , Fan Ye , Huang Chunxia , Liu Quanle , Huang Manhua , Chen Baijian , Peng Zhe , Zhu Wei , Ding Banghan
Published: July 2022

Objective

This study aimed to assess the adjunctive efficacy and safety of Puerarin injection (PI) on acute heart failure (AHF) based on a systematic review and meta-analysis.

Methods

Nine databases were searched from March 1990 to March 2022 to identify randomized controlled trials (RCTs) related to the adjunctive treatment of PI for AHF. The Cochrane collaboration tool was used to assess the risk of bias in the included studies. Meta-analysis and subgroup and sensitivity analyses were conducted by RevMan 5.3 software. The evidence’s certainty was evaluated by grading recommendations assessment, development, and evaluation (GRADE) methods.

Results

A total of 8 studies were included with a total of 614 patients with AHF. The meta-analysis demonstrated that adjunctive treatment with PI on AHF was superior to conventional medicine alone. It increased the total effective rate (RR = 1.38; 95% CI, 1.22–1.55; p < 0.001) and improved left ventricular ejection fraction [SMD = 0.85; 95% CI (0.62, 1.09); p < 0.001]. Regarding safety, a total of 11.9% (23/194) adverse reactions were observed in the PI group and 9.8% (19/194) adverse reactions in the control group, and there were no significant differences in the incident rate of adverse events between both groups [RR = 1.16; 95% CI (0.66–2.05); p = 0.061]. The outcomes’ evidentiary quality was assessed as “moderate.”

Conclusion

PI had an adjunctive effect on AHF combined with conventional medicine, and it seemed to be safe and more effective than the conventional medical treatment alone for improving the total clinical effective rate and left ventricular ejection fraction. But further well-designed RCTs are required to confirm the efficacy and safety of XBP in treating AHF due to the poor methodological quality of the included RCTs.

Systematic Review Registration:

[https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=327636], identifier [CRD42022327636].
Endothelial G protein stimulatory α-subunit is a critical regulator of post-ischemic angiogenesis
Authors: He Lifan , Lu Hanlin , Chu Jianying , Qin Xiaoteng , Gao Jiangang , Chen Min , Weinstein Lee S. , Yang Jianmin , Zhang Qunye , Zhang Cheng , Zhang Wencheng
Published: July 2022

Post-ischemic angiogenesis is a vital pathophysiological process in diseases such as peripheral arterial disease (PAD), heart ischemia, and diabetic retinopathy. The molecular mechanisms of post-ischemic angiogenesis are complicated and not fully elucidated. The G protein stimulatory alpha subunit (Gsα) is essential for hormone-stimulated cyclic adenosine monophosphate (cAMP) production and is an important regulator for many physiological processes. In the present study, we investigated the role of endothelial Gsα in post-ischemic angiogenesis by generating adult mice with endothelial-specific Gsα deficiency (GsαECKO). GsαECKO mice had impaired blood flow recovery after hind limb ischemic injury, and reduced neovascularization in allograft transplanted tumors. Mechanically, Gsα could regulate the expression of angiogenic factor with G patch and FHA domains 1 (AGGF1) through cAMP/CREB pathway. AGGF1 plays a key role in angiogenesis and regulates endothelial cell proliferation as well as migration. Knockdown of CREB or mutation of the CRE site on the AGGF1 promoter led to reduced AGGF1 promoter activity. In addition, knockdown of AGGF1 reduced the proangiogenic effect of Gsα in endothelial cells, and overexpression of AGGF1 reversed the impaired angiogenesis in GsαECKO mice in vivo. The finding may prove useful in designing new therapeutic targets for treatments of post-ischemic angiogenesis-related diseases.
Case report: An unusual case of desmin myopathy associated with heart failure and arrhythmia
Authors: Liu Xuhan , Liu Yuan , Li Bo , Wang Lin , Zhang Weihua
Published: July 2022

Introduction

Desmin myopathy is a novel desmin (DES) indel mutation that causes severe atypical cardiomyopathy as well as atrioventricular block and skeletal myopathy. The mutation of the gene of the nodal tail causes myocardial injury. Rarely does desmin myopathy cause bilateral ventricular changes.

Case presentation

We present a case of a 48-year-old man admitted with dyspnea and edema of both lower extremities. Due to bilateral lower limb weakness and calf muscle atrophy, gene sequencing was performed. The results showed that there was a pure missense mutation in the 8th exon region of the DES gene (c.1366G>A), encoding amino acid p.G456R (glycine>arginine). Supplementary examination suggests a high possibility of heart failure, atrial flutter, and desmin myopathy. Atrial flutter was treated by radiofrequency ablation. The clinical symptoms were stable after oral administration of rivaroxaban, coenzyme Q10, and ARNI.

Conclusion

In our case, mutation results are the gold standard for the diagnosis of desmin myopathy. Cardiac magnetic resonance can define the extent and degree of cardiomyopathy and quantitatively evaluate cardiac function. At present, there is a lack of specific treatment for proteolytic myopathy. Therefore, the treatment for heart failure proves effective. Due to the multiple systems involved, early diagnosis and multidisciplinary management are critical to improving patient outcomes.
Forsythiasides: A review of the pharmacological effects
Authors: Yang Hong-Xuan , Liu Qiu-Ping , Zhou Yan-Xi , Chen Yu-Ying , An Pei , Xing Yi-Zhuo , Zhang Lei , Jia Min , Zhang Hong
Published: July 2022

Forsythiasides are a kind of phenylethanol glycosides existing in Forsythia suspensa (Thunb.) Vahl, which possesses extensive pharmacological activities. According to the different groups connected to the nucleus, forsythiasides can be divided into A-K. In recent years, numerous investigations have been carried out on forsythiasides A, B, C, D, E, and I, which have the effects of cardiovascular protection, anti-inflammation, anti-oxidation, neuroprotection, et al. Mechanistically, forsythiasides regulate toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor kappaB (NF-κB), nuclear factor-erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) and other signaling pathways, as well as the expression of related cytokines and kinases. Further exploration and development may unearth more treatment potential of forsythiasides and provide more evidence for their clinical applications. In summary, forsythiasides have high development and application value.
The characteristics and formation mechanism of double-band radar echoes formed by a severe rainfall occurred in the Sichuan Basin under the background of two vortices coupling
Authors: Dong YuanChang , Li GuoPing , Jiang XingWen , Wang YuanCheng
Published: July 2022

During 29–30 UTC June 2013, a severe rainfall event with a long and narrow region of strong precipitation occurred in the central of the Sichuan Basin (SCB). Under the combined influence of a Tibetan Plateau vortex (TPV) and a southwest vortex (SWV), two banded strong radar echoes existed and developed simultaneously over the SCB. The analysis reveals that the vertical wind shear (VWS) caused by the circulations of the TPV and the SWV was the dominant factor of the formation and development of the radar echoes over the SCB. During the coupling period of the two vortices, the SWV provided abundant water vapor at the middle and lower levels over the SCB and the updrafts of the two vortices break through that formed deep convection, which made the precipitation in the SCB reach the maximum intensity. The enhancement of horizontal vorticity caused by the baroclinicity and the secondary circulation related to the two vortices created conditions for the formation of the double-band radar echoes. The matching degree of water vapor and heating conditions accompanying the circulation of the two vortices could affect the developments of convective storms and precipitation.
The Chronology of Early Human Settlement in Three Gorges Region, China—Contribution of Coupled Electron Spin Resonance and Uranium-Series Dating Method
Authors: Han Fei , Bahain Jean-Jacques , Shao Qingfeng , Sun Xuefeng , Voinchet Pierre , Xiao Ping , Huang Manchen , Li Mengqi , Yin Gongming
Published: July 2022

The Three Gorges region (TGR) located in the geographic center of China, is a transition zone between mountain and plain areas, and a probable migration corridor for hominins and other mammals between South and North China. Detailed chronological information of paleoanthropological evidence in this area could help us better understand the human evolution in East Asia. The OSL and U-series dating methods are two conventional dating methods generally adopted to date such sites; however, their applications were limited by the dating range—restricted to several hundred of millennia and ambiguous stratigraphic relationship between the archaeological remains and the dating target materials. Cosmogenic nuclide burial dating of quartzite stone artifacts and coupled electron spin resonance and uranium series dating (ESR/U-series) of fossil teeth have the potential to date Early–Middle Pleistocene hominin sites in Asia and were applied increasingly in China in recent years. However, the application of cosmogenic 26Al/10Be burial dating is limited in TGR because most sites are dominated by limestone, leading to the scarcity of the quartz component. In this case, the coupled ESR/U-series method plays a more important role in the establishment of the chronology of human settlement. In TGR, by using the coupled ESR/U-series method, we have dated seven important Early and Middle Pleistocene hominin settlement sites, including Longgupo, Jianshi, Yunxian, Meipu, Bailongdong, Changyang, and Yumidong sites. Based on our dating results, we propose that hominins were settled in TGR probably from the early stage of Early Pleistocene (∼2.5−2.2 Ma) at the Longgupo site to the late Middle Pleistocene to Late Pleistocene of the Yumidong site (∼274−14 ka) and very likely to spread to other parts of East Asia during this time period. In view of the potential of coupled ESR/U-series dating on fossil teeth from the hominin sites in the TGR, future work may consider the micro damage or non-destructive analysis of enamel fragment with the ESR method and laser ablation ICP-MS techniques that will make possible the direct dating of precious human fossils in China.
Quantitative evaluation of tight oil reservoirs in the Chang 8 Member of the Yanchang Formation in southern Ordos Basin
Authors: Luan Beibei , Zhang Bo , Wang Didong , Deng Chao , Wang Feng
Published: July 2022

The precise and quantitative characterization of reservoir properties is the key to efficient development of tight oil reservoirs. In this paper, taking the Chang 8 Member of the Yanchang Formation in the Shuimogou area in the southern Ordos Basin as an example, the sedimentary facies types, microscopic pore structures, diagenesis, influencing factors of physical properties, and hydrocarbon enrichment law of tight oil reservoirs are systematically studied. The research results show that the Chang 8 Member in the study area is a typical delta front subfacies deposit, including distributary channel and inter-distributary bay microfacies. The constructive diagenesis of the Chang 8 Member include dissolution, metasomatism and rupture; while the destructive diagenesis include mechanical compaction and cementation. The Chang 8 reservoir has entered the middle diagenetic stage A. The factors affecting the physical properties of tight oil reservoirs include deposition, compaction, cementation and dissolution. The secondary pores formed by dissolution account for 10–40% of the total surface porosity, with an average value of 24%. Local structures and sediments have significant control over hydrocarbon accumulation. The westward dipping tectonic setting of the northern Shaanxi Slope provides the basic conditions for the migration of oil and gas to the eastern updip areas. The changes of lithology and physical properties in the updip direction of the structure form the blocking conditions for the continued migration of oil and gas, which is conducive to the accumulation of oil and gas. In addition, the main oil reservoirs are mainly distributed along the distributary channel of the delta front, and most of the distributary channel sandstone is more than 20 m thick. The areas of thick sand body with multiple layers in the lateral direction is the main part of oil and gas accumulation. However, the reservoirs formed on the flanks of underwater distributary channels are generally thin and poorly sorted, which is not conducive to the accumulation of hydrocarbons.
Petrogenesis of early–middle paleozoic granitoids in the qilianblock, northwest China: Insight into the transition from adakitic to non-adakitic magmatism in a post-collisional extensional setting
Authors: Zhao Jiao-Long , Chen Wan-Feng , Wang Jin-Rong , Tang Qing-Yan , Wang Er-Teng , Fu Yi-Qiao
Published: July 2022

To better understand geodynamic implications for the transition from adakitic to non-adakitic magmatism in a continental collision setting, an integrated study including zircon U–Pb ages and whole-rock geochemistry was performed for the Gahai and Erhai granitoid intrusions within the Qilian Block. The ca. 450–428 Ma Gahai biotite granite and Erhai muscovite-bearing granite are peraluminous S-type granites with adakitic geochemical characteristics, and have low Mg# (41.2–31.7) and εNd(t) (−10.8 to −6.5) values with two–stage Nd model ages of 2.05–1.72 Ga, implying their derivation almost entirely from an ancient crustal source under a thickened lower crust condition. The geochemical characteristics of the granites indicate that the Gahai and Erhai S-type granites were derived from partial melting of meta-greywacke and meta-pelite sources, respectively. In comparison, the ca. 415 Ma Gahai granodiorite belongs to metaluminous I-type granitoid and has low Sr/Y ratios as well as high Y and heavy rare Earth element (REE) concentrations, with nearly flat heavy REE patterns, implying a shallow source region. The granodiorites were most likely generated by partial melting of a K-rich basaltic magma source, with some contributions from mantle-derived melts. Synthesized data from this and previous studies suggest that the ca. 450–415 Ma Gahai and Erhai granitoids within the Qilian Block were generated in a post-collisional extensional regime triggered by the break-off of the northward subducting South Qilian Ocean slab beneath the Qilian Block. The geochemical transition from adakitic to non-adakitic intermediate-acidic magmas indicated that the thickened continental crust of the Qilian Block had experienced significant extension and thinning after ca. 420 Ma.
Effect of teachers’ asynchronous e-feedback and synchronous oral feedback on English language learners’ writing accuracy
Authors: Nusrat Aasia , Khan Sardaraz , Kashif Farah , Fawad Rakhshanda
Published: July 2022

This research aims to assess the efficacy of electronic feedback (e-feedback) and traditional oral feedback on undergraduate students’ English writing over 12 weeks of teaching. Three treatment groups were involved: Asynchronous written e-feedback through Microsoft Word Track Changes; teacher–student oral metalinguistic conferencing; no feedback control group. Two grammatical features (i.e., conjunctions and articles), the most problematic forms, were targeted to determine the effect of feedback on these grammatical features. One-way ANOVA test resulted to reveal that the feedback-receiving group performed better than those given no feedback at all. Furthermore, students who received e-feedback performed much better in improving conjunctions errors than those who received oral feedback. The study suggests to train learners and teachers toward e-feedback for better learning of English language.
A Big Role for microRNAs in Gestational Diabetes Mellitus
Authors: Masete Matladi , Dias Stephanie , Malaza Nompumelelo , Adam Sumaiya , Pheiffer Carmen
Published: July 2022

Maternal diabetes is associated with pregnancy complications and poses a serious health risk to both mother and child. Growing evidence suggests that pregnancy complications are more frequent and severe in pregnant women with pregestational type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) compared to women with gestational diabetes mellitus (GDM). Elucidating the pathophysiological mechanisms that underlie the different types of maternal diabetes may lead to targeted strategies to prevent or reduce pregnancy complications. In recent years, microRNAs (miRNAs), one of the most common epigenetic mechanisms, have emerged as key players in the pathophysiology of pregnancy-related disorders including diabetes. This review aims to provide an update on the status of miRNA profiling in pregnancies complicated by maternal diabetes. Four databases, Pubmed, Web of Science, EBSCOhost, and Scopus were searched to identify studies that profiled miRNAs during maternal diabetes. A total of 1800 articles were identified, of which 53 are included in this review. All studies profiled miRNAs during GDM, with no studies on miRNA profiling during pregestational T1DM and T2DM identified. Studies on GDM were mainly focused on the potential of miRNAs to serve as predictive or diagnostic biomarkers. This review highlights the lack of miRNA profiling in pregnancies complicated by T1DM and T2DM and identifies the need for miRNA profiling in all types of maternal diabetes. Such studies could contribute to our understanding of the mechanisms that link maternal diabetes type with pregnancy complications.
Study on Obtaining Real Power Curve of Wind Turbines Using SCADA Data
Authors: Dai Juchuan , Zeng Huifan , Zhang Fan , Chen Huanguo , Li Mimi
Published: July 2022

The key problem to be solved in the process of wind turbine (WT) operation and maintenance is to obtain the wind turbine performance accurately. The power curve is an important indicator to evaluate the performance of wind turbines. How to model and obtain the power curve of wind turbines has always been one of the hot topics in research. This paper proposes a novel idea to get the actual power curve of wind turbines. Firstly, the basic data preprocessing algorithm is designed to process the zero value and null value in the original supervisory control and data acquisition (SCADA) data. The moving average filtering (MAF) method is employed to deal with the wind speed, the purpose of which is to consider the comprehensive result of wind on the wind turbine power in a certain period. According to the momentum theory of the ideal wind turbine and combined with the characteristics of the anemometer installation position, the deviation between the measured wind speed and the actual wind speed is approximately corrected. Here, the influence of dynamic changes in air density is also considered. Then, the Gaussian fitting algorithm is used to fit the wind-power curve. The characteristics of the power curve before and after wind speed correction are compared and analyzed. At the same time, the influence of the parameter uncertainty on the reliability of the power curve is considered and investigated. Finally, the characteristics of the power curves of four wind turbines are compared and analyzed. The research results show that among these power curves, WT3 and WT4 are the closest, WT2 is the next, and WT1 has the farthest deviation from the others. The research work provides a valuable basis for on-site performance evaluation, overhaul, and maintenance of wind turbines.
Optimal Coordinated Frequency Regulation of Renewable Energy Systems via an Equilibrium Optimizer
Authors: Zhao Mintong , Huan Jiajia , Huang Xin , Yu Tao , Ding Qiaoyi
Published: July 2022

With the urgency of environmental protection, wind power and photovoltaic (PV) projects are continued to be implemented, and the proportion of renewable energy in the power grid will be higher and higher. Therefore, wind power and PV also began to participate in the regional power grid frequency regulation (FR) and have gradually replaced the role of thermal power units in the power grid. To study the characteristics of renewable energy in frequency modulation, an automatic generation control (AGC) model of wind power and photovoltaic participating in the power grid FR is established. At the same time, an equilibrium optimization is proposed to allocate the total power in real-time so as to improve the FR performance by quickly obtaining the optimal power distribution scheme. The simulation results of the proposed model show that the proposed method is feasible. At the same time, the proposed method is compared with the genetic algorithm (GA), which proves the superiority of the proposed method.