bluuebunny/crossref_metadata_2025 huggingface dataset:
HUBUNGAN PRAKTIK PEMBERIAN MAKAN DENGAN KEJADIAN BERAT BADAN KURANG PADA ANAK USIA 6-24 BULAN DI WILAYAH KERJA PUSKESMAS SIDOARJO
Authors: Suryani Irma Dwi , Andrias Dini Ririn
Published: January 2024

There are many problems arise related to feeding practices and breastfeeding pattern among children aged 6-24 months which is not suitable with the recommendation, such as not exclusively breastfeeding until infant aged 6 months, prelactal food, introduction of soft food, semi solid or solid foods for children whose age appropriate feeding, and food diversity. This study aims to analyze the association between feeding practices and underweight of children under two. This study was an observational analytic study with cross-sectional design. Using structured questionaire, interview was conducted to 51 mothers or caregivers who have children aged 6-24 months old and was selected by simple random sampling technique in Bluru Kidul and Magersari, Sidoarjo. Underweight was obtained from anthropometry data. Weight was measured by using baby scale and digital scale. Result of this research showed that there was no significant association between underweight of children under two with predominant breastfeeding, food diversity, and meal frequency as well as 6 months exclusive beastfeeding and duration of breastfeeding (p>0,05). This study concludes that there is no association between breastfeeding patterns and feeding practices with underweight of children aged 6-24 months. It is necessary to conduct further research on finding association between feeding practices and underweight of children aged 6-24 months by standardized anthropometric measuring tools to confirm results of this study in the same location.Keywords: breastfeeding, children aged 6-24 months, feeding, underweight
PERANAN DUKUNGAN PENDAMPING DAN KEBIASAAN MAKAN PASIEN KANKER SELAMA MENJALANI TERAPI
Authors: Caesandri Stefana Danty Putri , Adiningsih Sri
Published: January 2024

Cancer patients had a decrease in appetite which leads to weight loss and nutritional status due to the cancer itself or the side effect of therapy. The existence of family support as a chaperone has an important role in the nutritional fulfillment of cancer patients as a form of instrumental support. The aim of this research was to identify the role of family support and the eating habit of cancer patients during undergo a therapy while living in Rumah Singgah Sasana Marsudi Husada, Cancer Foundation Indonesia branch of East Java. This was a descriptive research with cross sectional study design. The sample was total population of cancer patients for about 20 people. Data collected by interview including the role support from chaperone and eating habit of cancer patients which includes the type and frequency of eating. The type and frequency of eating were categorized according to Healthy Eating Index. This research found that 15% respondents who have good diet obtain the good role of chaperone support and respondents who included as diet needs improvement obtain the role of good chaperone support (30%) and quiet chaperone support (35%). The conclusion is that eating habit of cancer patients not only influenced by the role of chaperone support, but also influenced by characteristics of cancer patients. Cancer patients should improve their food intake, especially fruit, vegetable, and milk intake to achieve good diet. Keywords: eating habits, cancer patient, role of chaperone support, therapy
DAYA TERIMA DAN INDEKS GLIKEMIK MAKANAN BROWNIES YANG DIPERKAYA TEPUNG BERAS MERAH DAN KURMA
Authors: Ruslan Melissa , Adi Annis Catur , Andrias Dini Ririn
Published: January 2024

People with diabetes mellitus need low glycemic index snack to support their nutritional requirement and to control blood glucose levels. The research objective was to analyze the acceptability (color, flavor, texture, and taste) and the glycemic index of brownies enriched with red rice flour (Oryza nivara) and dates (Phoenix dactylivera). Completely randomized factorial design with 5 repetitions was used on 5 formulas, one control formula (F0) and 4 modification formulas; F1 (25% red rice flour and 24% dates), F2 (75% red rice flour and 24% dates), F3 (25% red rice flour and 40% dates), and F4 (75% red rice flour and 40% dates). Four professional panelist and 30 non skilled panelists were recruited. Friedman test and Wilcoxon Sign Rank Test at α=0.05 was used to test the difference between group. Formula F2 has the highest acceptability (color, flavor, texture, and taste) with an average value of 2.83, while the lowest acceptability was found in F3 (25% brown rice flour and 40% of dates) with an average value of 2.40. The glycemic index of brownies formula F2 is 41.97. Brownies F2 which substitute wheat flour with red rice flour (25%:75%) and enriched with dates (24%) was the best modification brownies formula for its color, flavor, and texture with glycemic index of 41.97. Adding other ingredients to brownies can be done to improve the taste and lower glycemic index at the best formula (F2),Keywords: brownies, dates, glycemic index, red rice flour
HUBUNGAN ASUPAN MIKRONUTRIEN DENGAN KADAR HEMOGLOBIN PADA WANITA USIA SUBUR (WUS)
Authors: Sahana Oky Nor , Sumarmi Sri
Published: January 2024

Women in reproductive age is a group that are more susceptible to anemia. Anemia is caused by a deficiency of various nutrients in the body which existence affects each other and it can lower the immune system then increased risk of morbidity. The aim of this study was to analyze the relationship between intake of iron, vitamin A, vitamin B2, vitamin B6, vitamin C, folic acid, and zinc with hemoglobin level among women in reproductive age. This cross sectional study was conducted in 9 subdistricts in Probolinggo and subjects were 71 people selected by simple random sampling using secondary research data in 2014. Micronutrients intake data obtained by 24 hours recall method then compared to RDA. Hemoglobin level measured by Hemocue. Data was analyzed using the Pearson correlation test. The result showed the average of hemoglobin level was 12.01 ± 1,24 g/dl and anemia prevalence was 42.25%. Statistical analysis showed that vitamin A intake is correlated to hemoglobin level (p = 0.015; r = 0.287). Further analysis is done by dividing respondents into two groups, anemic and not anemic to analyze the difference of the average of micronutrients intake. The sufficient level of vitamin A and vitamin B6 were adequate (≥ 77% RDA), but only vitamin A that significantly associate to hemoglobin level. Keywords: micronutrient intake, hemoglobin level, Women in reproductive age
Sex Identification of the Sun Conure (Aratinga solstitialis) Using Calamus Based on Polymerase Chain Reaction
Authors: Pinayungan Probo Probo Warih Tatag , Aprinda Ratna Lovela  , Eduardus Bimo Aksono  , Ismudiono  , Boedi Setiawan  , Kadek Rachmawati  , Jola Rahmahani
Published: January 2024

Sex identification of Sun Conures (Aratinga solstitialis) is crucial for breeding and preservation, as well as increasing sun conure populations. These birds are sexually monomorphic. Therefore, Determination between male and female carried out by their morphology examination. The Polymerase Chain Reaction (PCR) method, utilizing molecular-based technology, was employed to determine the sex of Aratinga solstitialis in this study. The P2 and P8 primers were utilized in this method, which has been deemed suitable and accurate for sex identification through calamus samples. The research focused on two 28-month-old Aratinga solstitialis birds. Calamus samples were collected and subjected to PCR amplification using the extracted calamus. The resulting PCR products were then visualized using electrophoresis with a 1% agarose gel. In the electrophoresis photo, the presence of two bands indicated a female specimen, whereas a single band indicated a male specimen. The result of the gel electrophoresis research showed that both of the Aratinga solstitialis were male with one band of each bird on ranged from 300-400 base pairs. The result show that the Polymerase Chain Reaction method in terms for sex identification on monomorphic birds, especially Aratinga solstitialis birds is very effective to differentiate the sex of young birds and the adults.
DEMOCRACIA FUGITIVA E TOTALITARISMO INVERTIDO DE SHELDON S. WOLIN
Authors: Netto de Andrade e Silva Sahd Luiz Felipe
Published: January 2024

Este artigo questiona a dimensão crítica da democracia analisada por Sheldon S. Wolin. A partir da década de 1980, o impulso de Wolin de diagnosticar as falhas da democracia americana ao conectar o liberalismo ao totalitarismo se manifesta de uma nova maneira. Ele observa que, no processo de lutar ostensiva- mente contra o totalitarismo durante a Guerra Fria, o próprio governo americano passou a incorporar uma forma totalizante de poder. Essa crítica culmina em seu diagnóstico de uma crise do século XXI: a condição neoliberal de “totalitarismo invertido”. Aqui Wolin argumenta não apenas que o sistema político americano compartilha algumas características com o totalitarismo, mas também que está começando a constituir uma nova versão do totalitarismo emergindo de dentro, e não em reação ao liberalismo.
Palavras-chave: Democracia. Totalitarismo. Liberalismo.
AWE AT NATURAL BEAUTY AS A RELIGIOUS EXPERIENCE
Authors: Porcher José Eduardo , De Luca-Noronha Daniel
Published: January 2024

In this paper, we discuss an abductive argument for the existence of God from the experience of awe at natural beauty. If God’s creative work is a viable explanation for why we experience awe at natural beauty, and there is no satisfactory naturalistic explanation for the origins of such experiences, then we have defeasible evidence that God exists. To evaluate the argument’s tenability, we assess the merits of the two main theocentric frameworks that can be marshaled to answer the question of why human beings experience awe at natural beauty: (1) taking the experience of natural beauty as resulting from God’s design intentions and (2) conceiving experiences of natural beauty as religious experiences in themselves. We argue that the presence of phenomenological content the fine-grainedness of which exceeds our descriptive and conceptual capacities is better accounted for by the latter hypothesis: experiencing natural beauty amounts to experiencing divine attributes. We conclude that the argument’s theological premise is tenable and, having previously argued for the empirical premise (Porcher & De Luca-Noronha, 2021), we conclude that awe at natural beauty is best explained by the existence of God.

Keywords: Awe. Natural Beauty. Religious Experience. Divine Beauty. God.
O ESPAÇO LÓGICO DAS RAZÕES DE WILFRID SELLARS E A RACIONALIDADE DO DISCURSO RELIGIOSO: UMA VINDICAÇÃO
Authors: Silva Gabriel Ferreira da , Ribolli Alex
Published: January 2024

Resumo: O problema básico a cuja resposta se almeja nesse artigo é o problema geral da epistemologia da filosofia da religião: é possível falar de uma racionalidade, de um modo geral, do e no discurso religioso? É racional, a título de exemplo, falar-se – e, mais ainda, defender – proposições como “há vida depois da morte”, “existe Deus”, “a alma reencarna e é eterna”, “Jesus ressuscitou ao terceiro dia” etc.? Para uma plêiade de autores a resposta é negativa; para uma outra parcela, por outro lado, a resposta é justamente a oposta. Em ambos os casos, não discutiremos o conteúdo da defesa daqueles ou que negam ou que defendem a racionalidade de uma proposição como as mencionadas, mas focalizaremos na concepção de subjetividade subjacente às teses negativas. Esse trabalho, assim, pretende apresentar uma proposta alternativa de defesa do discurso religioso. Em um primeiro momento, busca-se evidenciar que a desconsideração do caráter racional do discurso (ou proposições) religioso pressupõem uma concepção deflacionária de racionalidade. Intentar-se-á evidenciar que essa concepção “deflacionária” de racionalidade é dependente de certa tradição empirista. O segundo segmento inicia com um apontamento das fragilidades de uma tal concepção de racionalidade, abrindo-se espaço, portanto, para a apresentação de uma posição inferencialista a partir de Wilfrid Sellars (1912-1989). Conclui-se, portanto, pela racionalidade do discurso religioso, na medida em que se explicita a falsa pressuposição, uma concepção reducionista de subjetividade, das teses que negam tal possibilidade.
Palavras-chave: Wilfrid Sellars. Racionalidade. Empirismo. Religião.
FRONTEIRAS ENTRE MÍSTICA E ESTÉTICA NO SÉCULO XX: UNDERHILL, JANKÉLÉVITCH E GARCÍA BACCA
Authors: Gontijo Clovis Salgado , Almeida Franklim Drumond de , García Alberto Ferrer
Published: January 2024

A mística, embora implique certa relação com o suprassensível, apresenta traços fenomenológicos comuns com a experiência sensível do belo e com a criação artística. Este artigo pretende examinar as imprecisas fronteiras entre a mística e a estética a partir de três autores do século XX, estudiosos de Plotino: Evelyn Underhill, Vladimir Jankélévitch e Juan David García Bacca. Primeiramente, será analisado o estatuto da sensibilidade, da beleza e da arte na espiritualidade de Underhill. Em seguida, será verificado de que modo o campo da inefabilidade, ressaltado ao longo da obra de Jankélévitch e, em particular, em sua estética musical, garante a aproximação entre as duas áreas. Em terceiro lugar, será investigada a confluência do caminho místico e do caminho da Beleza na leitura feita por García Bacca do itinerário, prescrito por Plotino, rumo ao Transcendente. A título de conclusão, serão destacados pontos de convergência e de divergência entre os autores.

Palavras-chave: Beleza. Arte. Inefabilidade. Transcendente. Neopla¬tonismo.
A PERQUIRIÇÃO DA TRANSCENDÊNCIA NO PENSAMENTO DO JOVEM HEIDEGGER
Authors: Drawin Carlos Roberto
Published: January 2024

O nosso artigo está dividido em duas partes. A primeira parte visa mostrar como o sentido da transcendência está profundamente enraizado em todo o pensamento heideggeriano. A segunda parte procura ilustrar essa hipótese de leitura recorrendo a alguns textos de juventude do filósofo e os interpretando a partir de diversos estudos sobre a gênese de sua obra. No entanto, pressupomos que a sua relação com o cristianismo não foi ultrapassada nem com a sua ruptura com o “sistema do catolicismo” e nem com o seu afastamento filosófico da teologia. Ao contrário, a experiência cristã, de certa forma, persiste em todo seu itinerário e está presente, mesmo após a “viravolta” (Kehre) dos anos trinta. Essa experiência, para além de qualquer adesão doutrinária, alimenta a questão acerca de Deus como a sempre impensada transcendência encarnada no pensamento da e na existência.

Palavras-chave: Heidegger, Transcendência, Experiência Cristã, Teologia, Crítica da Razão Moderna.
Small Extracellular Vesicles And Oxidative Pathophysiological Mechanisms In Retinal Degenerative Diseases
Authors: Romero Francisco Javier , Diaz-Llopis Manuel , Romero-Gomez M Inmaculada , Miranda María , Romero-Wenz Rebeca , Sancho-Pelluz Javier , Romero Belen , Muriach María , Barcia Jorge M
Published: January 2024

This review focuses on the role of small extracellular vesicles in the pathophysiological mechanisms of retinal degenerative diseases. Many of these mechanisms are related or modulated by the oxidative burden of the retinal cells. It has been recently demonstrated that cellular communication in the retina involves extracellular vesicles and that their rate of release and cargo features might be affected by the cellular environment and in some instances also mediated by autophagy. The fate of these vesicles is diverse, and could end up in the circulation and be used as markers, or target neighbour cells modulating gene and protein expression and eventually also angiogenesis. Neovascularization in the retina promotes vision loss in diseases such as diabetic retinopathy and age-related macular degeneration. The importance of micro RNAs, either as small extracellular vesicles’ cargo or free circulating, on the regulation of retinal angiogenesis is also discussed.
Exploring the Coordinated Development of Smart City Clusters in China: A Case Study of Jiangsu Province
Authors: Liang Bing , Shi Guoqing , Ye Taotao , Zhou Kexin , Sun Zhonggen
Published: January 2024

As urbanization has accelerated, China has started to build smart cities, which have formed smart city clusters. It is critical to coordinate development within smart city clusters to enhance the efficiency of city cluster construction. From the perspective of demographic economics, this study innovatively constructed an evaluation system for the coordinated development of smart city clusters and utilized the coupled coordination degree model to conduct an in-depth study of smart city clusters in Jiangsu Province. The results show that there are clear differences in the development between the three regions of Jiangsu Province: Southern Jiangsu, Central Jiangsu, and Northern Jiangsu. The development within Jiangsu Province is imbalanced, where the overall development trend is high in the southern region and low in the northern region. The main driving factors include geography, the Matthew effect, game thinking, and industrial structure. Accordingly, the results suggest the following recommendations for the coordinated development of smart city clusters: strengthening cross-regional cooperation, promoting data sharing and interoperability, deepening synergistic industrial development, and expanding innovation capacity.
Revisional surgery for malnutrition after SADI-S: Prevalence, Indications, Techniques and Outcomes. Single Center Experience.
Authors: Sánchez-Pernaute Andrés , Lasses Bibiana , López Antoñanzas Leyre , Rubio Herrera Miguel Ángel , Pérez-Ferre Natalia , Marcuello Clara , Torres Antonio José , Pérez-Aguirre Elia
Published: January 2024

Single-Anastomosis Duodeno-Ileal bypass with Sleeve Gastrectomy (SADI-S) is a modification of the duodenal switch in which only one anastomosis is performed, with a longer common limb and an expected less malabsorptive effect. The present study analyzes presentation and treatment of malnutrition after SADI-S. 258 consecutive patients undergoing SADI-S between May 2007 and September 2017 were included. The common limb length was 200 cm in 50 cases, 250 cm in 156 and 300 in 52. 30 patients were admitted for severe hypoalbuminemia and 16 patients were submitted to revisional surgery and constitute the series of our study. Mean weight before reoperation was 57 kg and mean body mass index (BMI) was 21 kg/m2. Mean number of daily bowel movements was 5,6. Mean time to reoperation was 56 months. Revisional surgery consisted mainly in elongation of the common limb. Mean weight regain was 14 kg and mean final BMI was 26 kg/m2. Daily bowel movements were decreased to 1,3. Factors related to hypoalbuminemia were hypertension, poor controlled diabetes, age over 55 years and a shorter common limb. Although SADI-S is expected to be less malabsorptive than previous biliopancreatic diversions, caution has to be taken with selected patients to avoid postoperative malnutrition.
Introduction and Advancements in Room Temperature Ferromagnetic Metal Oxide Semiconductors for Enhanced Photocatalytic Performance
Authors: Ayyakannu Sundaram Ganeshraja , Govinda raj Muniyandi , Ethiraj Dr. Jayashree , Vairavel Parimelazhagan , Alagarsamy Santhana krishna kumar
Published: January 2024

Recent developments in the field of room temperature ferromagnetic metal oxide semiconductors (RTFMOS) have shown promising potential for improved photocatalytic performance. This review focuses on the combined study of photocatalytic and ferromagnetic properties at room temperature, with a particular emphasis on metal oxides, such as TiO2, which have emerged as a key area of interest in the domains of magnetism and environmental remediation. Despite extensive research over the years, the precise mechanism behind the interplay of ferromagnetism and photocatalysis in these materials remains incompletely understood. Several critical factors contributing to magnetism have been hinted at, including oxygen vacancies and various metal doping. Numerous reports have demonstrated that these factors play a primary role in room temperature ferromagnetism and photocatalysis in wide-band-gap metal oxides. However, establishing a direct correlation between magnetism, oxygen vacancies, dopant concentration, and photocatalysis has proven challenging. This review aims to provide a comprehensive overview of the recent progress in understanding the magnetism and photocatalytic behaviour of metal oxides. By examining the latest findings, this study sheds light on the potential of RTFMOS as effective photocatalysts, thereby contributing to advancements in environmental remediation and related applications.
A Multidimensional Evaluation of the Factors in the Animal Welfare Assessment Grid (AWAG) That Are Associated and Predictive of Behaviour Disorders in Dogs
Authors: Malkani Rachel , Paramasivam Sharmini Julita , Wolfensohn Sarah
Published: January 2024

Behavioural disorders in dogs are common and have severe welfare consequences for dogs. This study aimed to assess the factors that are significant and predictive of behaviour problems in dogs using the Animal Welfare Assessment Grid (AWAG) to further understand what factors influence their welfare. 177 AWAG assessments were undertaken across 129 dogs that clinicians deemed to have a behavioural disorder. Wilcoxon-rank sum tests were used to assess the difference in scores between dogs with behaviour disorders and a cohort of healthy dogs (n=117). This analysis showed that all physical factors besides body condition, all procedural factors besides procedure pain, and all psychological, and environmental factors were significantly different between healthy dogs and dogs with behaviour disorders. Spearman Rank Correlation Coefficient (RS) revealed several significant strong positive correlations including the procedural impact on the dog’s daily routine with aggression towards unfamiliar people and procedure pain, as well as other correlations between the dog’s behaviour during assessment with the frequency at which they encounter fears and anxieties, clinical assessment and procedure pain, and reaction to stressors and social interactions. These findings highlight the interdependent nature of the various influences of welfare. Logistic regression analysis identified that aggression towards the caregiver, fears and anxieties frequency, and choice, control, and predictability were all significant predictors of behaviour disorders. The findings have important implications for veterinary, behaviour, and animal welfare professionals as any changes across these factors may indicate poor welfare linked to emotional disorders in dogs.
Rapid Determination Method of Reinforced Concrete Column Failure Modes using Simple Structural Information
Authors: Kim Subin , Hwang Hee-Jin , Oh Keunyeong , Shin Jiuk
Published: January 2024

Existing reinforced concrete buildings with seismically-deficient column details affect the overall behavior depending on the failure type of column. The purpose of this study is to develop and validate a machine learning-based prediction model for the column failure modes (shear, flexure-shear and flexure failure modes). For this purpose, artificial neural network (ANN), K-nearest neighbor (KNN), decision tree (DT), and random forest (RF) models were used considering previously-collected experimental data. Using four machine learning methodologies, we developed a classification learning model that can predict the column failure modes in terms of the input variables using concrete compressive strength, steel yield strength, axial load ratio, height-to-dept aspect ratio, longitudinal reinforcement ratio, and transverse reinforcement ratio. The performance of each machine learning model was compared and verified by calculating accuracy, precision, recall, F1-Score, and ROC. Based on the performance measurements of the classification model, the RF model represents the highest average value of the classification model performance measurements among the considered learning methods, and it can conservatively predict the shear failure mode. Thus, the RF model can rapidly predict the column failure modes with the simple column details. Additionally, it was demonstrated that the predicted failure modes from the selected model were exactly same as the failure mode determined from a code-defined equation (traditional method)
Rare Case of First Permanent Molar Primary Failure of Eruption with Agenesis of Premolars
Authors: Vinereanu Arina , Munteanu Aneta , Clauss Francois , Gorduza Eusebiu Vlad
Published: January 2024

Primary failure of eruption (PFE) is a rare non-syndromic condition involving total or partial non-eruption of posterior teeth, in the absence of mechanical obstruction. This paper presents the case of a healthy girl referred at age 4 years for asymmetry of upper arch. Clinical examination confirmed a slight shift of the upper midline to the left, with no erupted teeth distal to the upper left canine and left posterior open bite. Panoramic X-ray showed delayed intra-osseous development of lateral left upper teeth compared to the right side. Clinic and radiographic follow-up during the next 9 years showed that 26 has not erupted by almost 13 years of age, 27 has delayed development and an unusual shape and there is agenesis of 24, 25. Genetic analysis using the PTH1R single gene sequencing did not detect any known disease-causing or rare pathogenic variants that could explain the patient's phenotype. Even when detected early, PFE rises difficult problems with regard to diagnosis and ortho-surgical treatment planning due to the impossibility to accurately predict the evolution. Tooth agenesis on the same arch worsens the prognosis and adds challenges to planning the treatment. Close long-term follow-up and timely adjustment of treatment plan in accordance to the evolution of the case are needed.
The Dynamic Evolution Model of Chemical and Carbon Isotopic Composition of C1-3 during the Hydrocarbon Generation Process
Authors: Zhao Heng , Li Yanjie , Liu Wenhui , Zhang Guchun , Wang Yanjun
Published: January 2024

A new approach is presented for dynamic modeling of chemical and isotopic evolution of C1-3 during the hydrocarbon generation process. Based on systematic data obtained from published papers for pyrolysis of various hydrocarbon sources(type I kerogen/source rock, type II kerogen/source rock, type III kerogen/source rock, crude oil, asphalt, etc), the empirical evolution framework of chemical and isotopic composition of C1-3 during the hydrocarbon generation process was built. Although the empirical framework was built only by fitting large amount of pyrolysis data, the chemical and isotopic composition of C1-3 derived from the pyrolysis experiments all follow the evolution laws, convincing us that it is applicable to the thermal evolution process of various hydrocarbon sources. Based on the simplified formula of the isotopic composition of mixed natural gas at different maturities (δ13Cmixed)

δ13Cmixed=(X〖*n〗_iA 〖*δ〗^13 C_iA+Y〖*n〗_iB 〖*δ〗^13 C_iB)/(X〖*n〗_iA+Y〖*n〗_iB ),

it can be derived that the cumulative isotopic composition of alkane generated in certain maturity interval can be expressed by the integral of the product of instantaneous isotopic composition and instantaneous yield at certain maturity point, and then divided by the cumulative yield of alkane generated in corresponding maturity interval. Thus, the cumulative isotopic composition(A(X)), cumulative yield(B(X)), instantaneous isotope(C(X)),and instantaneous yield(D(x)) in the dynamic model comply with the following formula during the maturity interval of (X0-X)

A(X)=(∫_(X_0)^X▒〖C(X)*D(X)dx〗)/(B(X)),

where A(X) and B(X) can be obtained by fitting of pyrolysis data, and D(x) can also be obtained from the derivation of B(X).

The dynamic model was applied on the pyrolysis data of Pingliang Shale to illustrate the quantitative evolution of cumulative yield ,instantaneous yield, cumulative isotope and instantaneous isotope of C1-3 with increasing maturity.The dynamic model can quantify the yield of methane, ethane and propane as well as δ13C1, δ13C2 and δ13C3 respectively during the hydrocarbon generation process, which is of great significance to evaluate the natural gas resources of hydrocarbon source rock with different maturity and to identify the origin and evolutionary process of hydrocarbons by chemical and isotopic data. Moreover, this model provides an approach to study the dynamic evolution of isotope series of C1-3 (including reversed isotopic series), which is hopeful to reveal the mechanism responsible for isotopic reversal when combined with post-generation studies.
Mandibular Third Molar Impaction and Bone Change Distal to the Second Molar: Panoramic Radiography Study
Authors: Ahmed Hassan Assiri , López-López Jose , Egido-Moreno Sonia , Llabrés Xavier Roselló , Mohammed Shahul Hameed , Estrugo-Devesa Albert
Published: January 2024

Mandibular third molar is the most frequently impacted tooth. Mandibular third molar impaction bears consequences on the adjacent mandibular second molar (MSM) like bone loss. It can be identified initially using orthopantomography (OPG). The objective is to compare the changes in the bone level distal to MSM between patients with extracted and non-extracted impacted man-dibular third molars (IMTM) using OPG. In this retrospective case-control study, 160 archived (OPGs) of 80 patients visiting the Dental Hospital of the University of Barcelona (HOUB) were randomly selected. The participants were stratified into two groups. The study group involved measuring the bone level distal to the mandibular second molar before and after the extraction of the IMTM. The control group, on the other hand, had bone levels measured twice within 3–6-month period without the extraction of the IMTM. The mean ages of patients in study and control groups were 35.5 ± 15.45 and 33 ± 16.49, respectively. Study group demonstrated signifi-cant (p < 0.05) bone gain after extraction, whereas control group demonstrated significant bone loss (p < 0.0001) after follow-up. Bone improvements were observed distal to the mandibular second molar after the extraction of the IMTM compared to those in control group.
Addressing the Concerns Surrounding the Recent Outbreak of SARS-CoV-2 Subvariant BA.2.86 (Pirola)
Authors: Datta Neelabh
Published: January 2024

The emergence of SARS-CoV-2 subvariant BA.2.86, also known as Pirola, has raised concerns about its transmissibility, virulence, and immune escape. The aim of this letter is to address the current evidence on the origin, spread, and characteristics of Pirola, and discuss its implications for public health and vaccine development. The need for enhanced surveillance, genomic sequencing, and epidemiological studies to monitor the evolution and impact of Pirola and other SARS-CoV-2 variants are highlighted in this letter along with the importance of global cooperation and coordination to prevent and control future outbreaks of this novel coronavirus strain.
Polydatin in Cancer Research: Molecular Docking with UXS1 and Safety Profile Evaluation
Authors: Ferrari Ivan Vito , Ravagnan Giampietro
Published: January 2024

Polydatin, a polyphenolic compound sourced from various natural origins, has garnered attention due to its potential anti-tumor properties and low toxicity. This research utilized Molecular Docking methods to investigate the molecular interactions between Polydatin and the Crystal Structure of Human UDP-glucuronic acid decarboxylase (UXS1), aiming to uncover the mechanisms contributing to its anti-tumor effects. The study revealed a substantial binding energy value of approximately -10 kcal/mol for the Polydatin-UXS1 interaction, indicating a robust and favorable binding. This suggests that Polydatin holds significant promise in cancer research, offering insights into its ability to interact with and potentially modulate the activity of UXS1. Moreover, the additional step of predicting toxicity properties using the pKCSM server provides valuable insights into the safety profiles of polydatin ( or piceid). From these results, the parameters for polydatin: —Max. tolerated dose (human),- Oral Rat Acute Toxicity (LD50), and - Oral Rat Chronic Toxicity (LOAEL)—suggest a favorable safety profile.These findings position Polydatin as a compelling candidate for further exploration in cancer research, highlighting both its efficacy and safety considerations.
Staphylococcus capitis Central-Line Associated Bloodstream Infections (CLABSI) in the NICU: A Single-Center 4-Year Experience on Central Line Management during Sepsis Treatment
Authors: Sala Anna , Pivetti Valentina , Vittorini Alessandra , Viggiano Claudia , Castoldi Francesca , Fabiano Valentina , Lista Gianluca , Cavigioli Francesco
Published: January 2024

Coagulase negative Staphylococci (CoNS) are reported to be responsible for 50-60% of bloodstream infections in very preterm (<1500 g) infants in Neonatal Intensive Care Units (NICU). Staphylococcus capitis is an increasingly prevalent pathogen in neonatal setting, frequently causing central-line associated bloodstream infections (CLABSI) that can be difficult to eradicate. CVC removal versus in situ treatment of CoNS CLABSIs is a matter of debate, with no clear consensus emerging in the existing literature. We revised all S. capitis CLABSIs in our NICU between 2019 and 2022, focusing on the role of catheter removal for eradication. Among 25 cases, 17 CVCs were removed after diagnosis, leading to a 76.5% eradication rate in this group. 3 infants had a persistently positive blood culture after CVC substitution. A new catheter was than inserted after a 48-hours washout period, resulting in resolution of the infection. Only 2 of 8 patients (25%) who retained the catheter after diagnosis, underwent infection eradication with antibiotic therapy alone. Catheter removal, when feasible, seems to be the most effective strategy to eradicate S. capitis CLABSIs, sometimes even requiring a 48-hours washout period before reinsertion. Further studies on this subject are needed to better standardize the management of this kind of infections.
Enhancing Sustainability through Ecosystem Services Evaluation A Case Study of the Mulberry-Dyke and Fish-Pond System in Digang Village
Authors: Tang Shuyang , Liu Ziwei , Li Yumei , Zhou Mingqin
Published: January 2024

This research centers on the Mulberry-Dyke and Fish-Pond System in Digang Village, Huzhou, exem-plifying the traditional cyclic agricultural models of China. The study's objective is to evaluate its integral value concerning agricultural production, ecological environment, and heritage conservation. Employing the Analytical Hierarchy Process (AHP) and Fuzzy Comprehensive Evaluation (FCE) methodologies, we developed a comprehensive evaluation framework comprising 8 dimensions and 29 factors, aimed at assessing the provisioning, regulating, and cultural services of this ecosystem. The findings indicate a robust performance of the ecosystem services in Digang Village's Mulberry-Dyke and Fish-Pond System, with cultural services significantly standing out. In contrast, the regulating services appeared relatively weaker, pinpointing shortcomings in mulberry land management, while the provisioning services demonstrated substantial strength. These insights are pivotal for comprehending the system's ecosystem service values, highlighting areas for managerial improvements, and guiding future assessment and management strategies. This study contributes theoretical insights and empirical experiences for future evaluations of the Mulberry-Dyke and Fish-Pond System's ecosystem services.
Detailed Finite Element Models for the Simulation of Laser Shock Wave Response of 3D Woven Composites
Authors: Tserpes Konstantinos , Kormpos Panagiotis
Published: January 2024

This paper presents a numerical study on the laser shock wave propagation in a 3D woven CFRP material by means of detailed and homogenized FE models. The aim of the study is to numerically characterize the shock wave response of the 3D woven CFRP in terms of back face velocity profiles and the induced damage and to investigate whether the detailed FE models could be replaced by homogenized FE models. The 3D woven geometry was designed using the TexGen software, while the numerical analyses were executed using the LS-Dyna explicit FE software. A high-strain rate behavior was considered for the matrix. The fiber bundles in the detailed models were modeled as a high fiber content unidirectional composite laminate, with its mechanical properties calculated by micromechanical equations. Both for the fiber bundles of the detailed model and the homogenized models a progressive damage material model was applied. The results of the detailed model reveal a considerable effect of material’s architecture on the shock wave propagation and the sensitivity of the back face velocity profile to the spot location. Consequently, the homogenized model is not capable of accurately simulating the shock wave response of the 3D woven composite. Moreover, the detailed predicts with high accuracy matrix cracking in the resin-rich areas and in the bundles as well as fiber failure. On the contrary, the homogenized model predicts matrix cracking at the same areas and no fiber failure.
The Ethylene Biosynthetic Enzymes, 1-Aminocyclopropane-1-Carboxylate (ACC) Synthase (ACS) and ACC Oxidase (ACO): The Less Explored Players in Abiotic Stress Tolerance
Authors: Khan Sheen , Alvi Ameena Fatima , Saify Sadaf , Iqbal Noushina , Khan Nafees
Published: January 2024

Ethylene is an essential plant hormone critical in various physiological processes. These processes include seed germination, leaf senescence, fruit ripening, and the plant's response to environmental stressors. Ethylene biosynthesis is tightly regulated by two key enzymes, namely 1-aminocyclopropane-1-carboxylate synthase (ACS) and 1-aminocyclopropane-1-carboxylate oxidase (ACO). Initially, the prevailing hypothesis suggested that ACS is the limiting factor in the ethylene biosynthesis pathway. Nevertheless, accumulating evidence from various studies has demonstrated that ACO, under specific circumstances, acts as the rate-limiting enzyme in ethylene production. Under normal developmental processes, ACS and ACO collaborate to maintain balanced ethylene production, ensuring proper plant growth and physiology. However, under abiotic stress conditions, such as drought, salinity, extreme temperatures, or pathogen attack, the regulation of ethylene biosynthesis becomes critical for plants’ survival. This review highlights the structural characteristics, examines the transcriptional, post-transcriptional, and post-translational regulation of ACS and ACO, and their role under abiotic stress conditions. Reviews on the role of ethylene signaling in abiotic stress adaptation are available. However, a review that delineates the role of ACS and ACO in abiotic stress acclimation is not available.
Real-Time Batch Optimization for the Stochastic Container Relocation Problem
Authors: Zhou Sifang , Zhang Qingnian
Published: January 2024

The container relocation problem (CRP) is one of the important topics in container terminals, which aims to find the optimal sequence of movements to minimize the total number of relocations needed to retrieve all the containers within a bay according to a given specific layout and retrieval order. However, determining such an order may be difficult due to uncertainty. Various CRP solution methods proposed so far show a common pitfall concerning the complexity of the solving process, whose scale grows exponentially with the number of containers. Considering the retrieval operation process of the inbound containers in a bay consists of several operation rounds, this paper focuses on the real-time operation scenario of each round to minimize the actual number of relocations during the pick-up process, i.e., starting from the initial layout of the bay, we minimize the sum of the incremental number of blocking containers due to the layout change and the number of reallocated containers unrelated to the target container. We present a heuristic algorithm (called SPFH) based on the three rules (LL, MSS, and FSS), considering the adjustment of the pick-up order of containers. Numerical experiments on a set of instances generated from the literature are performed. The proposed methodology excels in both execution efficiency and solution quality and is capable of solving instances that were impossible to solve before. This also makes our methods appealing for being applied in practice. The source codes are available at https://github.com/zhou-sf/rt-scrp.
Superior Mesenteric Artery Syndrome Results From Hypersecretion of Hydrochloric Acid
Authors: Levin Michael
Published: January 2024

It is currently believed that the cause of superior mesenteric artery syndrome (SMAS) is compression of the duodenum in the angle between the aorta and superior mesenteric artery (SMA). It is recognized that a decrease in aortomesenteric angle (AMA) <25° and intervascular distance < 8 mm, caused by fat loss, is characteristic of SMAS. Based on these statements, surgeons operate on patients with symptoms of dyspepsia only based on a reduction of AMA. This study is devoted to the analysis of the literature, including four own studies on this issue. Results: Measurement of the length of the constriction in the third part of the duodenum on radiograms from available sources showed that its true length ranged from 2.5 to 4.2 (3.30±0.15) cm and began a few centimeters cranial to the AMA. Therefore, it could not have been caused by compression in the AMA. In terms of length (3.20±0.15 cm) and location, this constriction corresponded to Ochsner’s sphincter, which normally short-term contracts to prevent the penetration of an acid bolus into the jejunum. Conscientious studies have shown that AMA is proportional to BMI, i.e., a decrease in AMA is observed in all thin people. An analysis of 211 cases of SMAS made it possible to differentiate two types of diseases. In 101 patients, the disease occurred acutely 1–53 (8.2 ± 1.9) days after stressful situations, accompanied by a catabolic reaction and hypersecretion of hydrochloric acid. In 110 patients, SMAS developed 3-72 (17.2±3.2) months after the diagnosis of acid-dependent diseases. Conclusion: The analysis of the literature led to the conclusion that hypersecretion of hydrochloric acid causes damage to the upper level of the digestive system, including duodenal dyskinesia. One of the manifestations of duodenal dyskinesia is an increase in tone and hypertrophy of the Ochsner’s sphincter. The clinic of the disease depends on the varying degree of Ochsner’s sphincter dyskinesia. In severe cases, partial or complete intestinal obstruction. New ideas about the etiology and pathogenesis of the so-called SMAS have made it possible to propose a tactic for the diagnosis and treatment of Ochsner’s sphincter dyskinesia, where there is no place for surgical treatment.
Integrating Multimodal Ensemble and Spatiotemporal Analysis for Enhanced Climate Modelling in Nigeria
Authors: Olasehinde David Ayodeji , Adeniran Kamoru A , Ogunrinde Akinwale T. T.
Published: January 2024

The study combines two critical aspects of climate research in Nigeria. The first segment focuses on improving predictive performance of global circulation models (GCMs) employing ensemble techniques. ANN ensemble displayed significant improvement in the accuracy of climate projections, particularly in high-altitude geographic areas where traditional models exhibit limitations. Performance evaluation metrics such as Mean Absolute Error (MAE), Root Mean Squared Error (RMSE), and Nash–Sutcliffe Efficiency (NSE) demonstrate the effectiveness of the ANN multimodal ensemble. Building on the improved climate modelling, the second segment delves into a spatial and temporal analysis of rainfall and mean temperature patterns under climate change in Nigeria. By considering two Representative Concentration Pathways (RCPs), namely RCP4.5 and RCP8.5, the study utilizes dynamically downscaled GCMs obtained from the Coupled Model Intercomparison Project phase 5 (CMIP5). The Mann-Kendall test reveals significant spatiotemporal variations in climate trends across the country. The warming trend is particularly pronounced in the northern regions, with RCP8.5 showing more severe impacts compared to RCP4.5. This integrated approach not only highlights the importance of multimodal ensembles in climate modelling but also provides valuable insights into the spatial and temporal patterns of climate change to inform effective adaptation and mitigation strategies for Nigeria.
Trajectory Tracking Control for Quadrotors Using Adaptive Integral Terminal Sliding Mode under External Disturbances
Authors: Jiao Shipeng , Wang Jun , Hua Yuchen , Zhuang Ye , Yu Xuetian
Published: January 2024

To address the trajectory tracking issue for quadrotors working under the influence of external disturbances, a control scheme is designed for position and attitude trajectory tracking. Firstly, the quadrotor dynamic model is derived for control design. Secondly, adaptive integral backstepping control (AIBS) is employed in the position loop in which adaptive estimation is used to estimate the upper bounds of disturbances. Subsequently, a new adaptive backstepping fast nonsingular integral terminal sliding mode control (ABFNITSM) is proposed to follow desired Euler angles. The intro-duction of fast nonsingular terminal sliding mode and integral element is to realize fast convergence and accurate tracking. Dead zone technique is applied to minimize estimation errors. Besides, a saturation function is utilized to eliminate chattering phenomenon. Finally, simulation experiments are conducted under the Simulink environment. The proposed control is verified by comparing it with traditional integral terminal sliding mode control (ITSM) and integral backstepping control (IBS).
Validation and Suitability Assessment of Multiplex Mesoscale Discovery Immunogenicity Assay for Establishing Serological Signatures Using Vaccinated, Non-vaccinated and Breakthrough SARS-COV-2 Infected Cases
Authors: Shengule Sushant , Alai Shweta , Bhandare Sachin , Patil Sumant , Gautam Manish , Mangaonkar Bhushan , Gupta Sumit , Shaligram Umesh , Gairola Sunil
Published: January 2024

Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are multi-targeted and variable over time. Multiplex quantitative serological assays are needed to provide accurate and robust seropositivity data for establishment of serological signatures during vaccination and or infection. We describe here, validation and evaluation of an electro-chemiluminescence (ECL) based Mesoscale Discovery assays (MSD), for estimation of total and functional IgG to SARS-CoV-2 spike, nucleocapsid, and receptor binding (RBD) proteins in human serum samples to establish serological signatures of SARS-CoV-2 natural infection and breakthrough cases. The 9-PLEX assay was validated as per ICH, EMA and US FDA guidelines using a panel of sera samples including the NIBSC/WHO international reference panel (20/268). Assay demonstrated high specificity and selectivity in inhibition assays, wherein the homologous inhibition was more than 85% and heterologous inhibition was below 10 %. Assay also met predetermined acceptance criteria for precision (CV < 30 %), accuracy (70-130 %) and dilutional linearity. Method applicability to serological signatures was demonstrated using sera samples (N=45) representing vaccinated, infected and breakthrough cases. The method was able to establish distinct serological signatures and thus provide potential tool for seroprevalence of SARS-COV-2 during vaccination or infection.