bluuebunny/crossref_metadata_2025 huggingface dataset:
Public Confidence in COVID-19 Prevention and Response in Bangladesh
Authors: Alam Edris , Rahman Kazi Abdur , Hridoy Al-Ekram Elahee
Published: February 2022

Community confidence in institutional approaches to emergency management directs how they cooperate and comply with public policy responses. In the context of emerging COVID-19 pandemic risk management, this study aims to assess public confidence in the Government of Bangladesh (GoB) and private sector entities for the activities undertaken during preparedness, prevention, and response phases. A survey was conducted with 307 respondents who willingly took part in the study. Cronbach's alpha was calculated to assess the internal reliability and the Mann-Whitney U test was conducted to estimate the mean score difference between the observations. A confirmatory factor analysis (CFA) was applied in the study. The findings suggest that the participants were highly positive about the GoB efforts to organize and provide PPE for doctors in time as a safeguard against COVID-19 and coordination and informed decision making in relation to facing COVID-19. Overall, the participants showed a lower-level confidence in the preparedness and response measures taken by authorities in Bangladesh. The results explored how the GoB failed to reach the public satisfaction level regarding provision of food and financial support to low income and middle income people. A lack of collaboration and coordination among different inter-GoB and private sectors makes mitigation and recovery process difficult. This research provides a set of policy recommendations for future public health emergency management based on the participants' concerns and suggestions, and a review of consequences of policy responses in the early stage.
Exploring Key Factors for Contractors in Opening Prefabrication Factories: A Chinese Case Study
Authors: Zhang Jiasheng , Xiang Pengcheng , Zhong Jia , Zhang Jian , Wu Zezhou , Antwi-Afari Maxwell Fordjour
Published: February 2022

Adoption of prefabrication is essential for improving the urban built environment. However, the existing prefabrication market in China is far from mature. As the stakeholder who conducts construction activities, the contractor is facing a dilemma of lacking steady prefabricated components supply. In this circumstance, a potential solution is that contractors open their own prefabrication factories to guarantee stable component supply. The aim of this research is exploring the key factors for contractors to open prefabrication factories. Firstly, a total of 28 influencing factors were identified from literature. Then, the identified factors were divided into four categories: policy environment, market environment, technological environment, and enterprise internal environment. Through interviews with experienced professionals, a total of 19 factors were selected for future analysis. Based on the 19 factors, a questionnaire was designed and distributed to the experts to rate the degree of mutual influences. The collected data were analyzed using Ucinet6.0 software, and the adjacency matrix and the visual models were established. Finally, through the analysis of node centrality, betweenness centrality, and closeness centrality, the four key influencing factors were determined including mandatory implementation policy, precast concrete component's price, market demand, and contractor's strategic objectives. The results of this study could assist contractors in making decisions of opening their own prefabrication factories toward more sustainable environment.
Viral Infections and Male Infertility: A Comprehensive Review of the Role of Oxidative Stress
Authors: Akhigbe Roland E. , Dutta Sulagna , Hamed Moses A. , Ajayi Ayodeji F. , Sengupta Pallav , Ahmad Gulfam
Published: February 2022

Viral infections have been a part of human existence to date, though viruses have posed a huge threat with various outbreaks lately. These threats are associated with reproductive health challenges, especially male infertility. The prime focus of this review is to highlight the mechanisms associated with viral infection-induced male infertility/subfertility and identify new treatment strategies with the aim to preserve male fertility. The reviewed data showed that viral infections stimulate inflammatory responses, resulting in the release of proinflammatory cytokines, which induces oxidative stress. This oxido-inflammatory cycle could continue in a vicious cycle and threaten male fertility. Existing data from human and experimental studies show that viral infection-induced oxido-inflammatory response results in testicular damage, atrophy of the seminiferous tubules and Sertoli cells, and reduced Leydig cell mass. This is accompanied by reduced circulatory testosterone, impaired spermatogenesis, reduced sperm motility, lipid peroxidation, DNA fragmentation and apoptosis of the sperm cells. Based on the available pieces of evidence, antioxidant therapy,in vivoandin vitro, may be beneficial and protects against the potential risk of male infertility from viral infection. It is, however recommended that more clinical studies be conducted to demonstrate the possible protective roles of antioxidants used as adjuvant therapy in viral infections, and in thein vitrotreatment of semen samples for those utilizing semen washing and artificial reproductive techniques.
Greening the Virtual Smart City: Accelerating Peer-to-Peer Learning in Urban Agriculture With Virtual Reality Environments
Authors: Parikh Tapan , Egendorf Sara Perl , Murray Isaiah , Jamali Ali , Yee Bryan , Lin Sammi , Cooper-Smith Kendra , Parker Brendan , Smiley Koron , Kao-Kniffin Jenny
Published: February 2022

Urban agriculture is emerging across the United States (U.S.) as a distinct food production system that can help address food security and equity concerns of marginalized, urban communities. While urban farming is accelerating across the nation rapidly, the system of peer-to-peer learning that represents farmer education and training in the U.S. is based on rural agriculture. We describe the development of virtual reality (VR) platforms to support farmer knowledge transfer and innovation that transcend the physical constraints of traditional agricultural extension based on on-farm demonstrations. We feature a VR model representing an organic farm in New York City with details of farm operations, and opportunities to stack educational and training materials along with personal narratives, as part of the virtual farm demonstration. The potential for VR to accelerate innovations in food justice is a critical component of smart cities technologies and should be developed in parallel with modernization efforts with land grant universities and their cooperative extension networks of farmer-to-farmer education and training.
CD44-Mediated Poor Prognosis in Glioma Is Associated With M2-Polarization of Tumor-Associated Macrophages and Immunosuppression
Authors: Xiao Yong , Yang Kun , Wang Zhen , Zhao Mengjie , Deng Yanxiang , Ji Wei , Zou Yuanjie , Qian Chunfa , Liu Yong , Xiao Hong , Liu Hongyi
Published: February 2022

Background

Glioma is the most common primary brain tumor with a poor prognosis. Key genes that are negatively related to prognosis may provide the therapy targets to cure glioma. To clarify the role of CD44 in glioma, we explored its function at bulk-transcriptome, spatial and single-cell transcriptome levels.

Methods

In total, expression profiles with survival data of whole-grade glioma from The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA), RNA-seq data with anatomic information of glioblastoma (GBM) from the Ivy Glioblastoma Atlas Project, RNA-sequencing (RNA-seq) data from recurrent GBM receiving adjuvant anti-PD-1 immunotherapy accessed through GSE121810, and single-cell RNA-seq data of GBM under accession GSE103224 were enrolled in this study. CD44-specific findings were further analyzed by R language.

Results

CD44 is positively correlated with WHO grade of malignancy and is negatively related to prognosis in glioma. Meanwhile, CD44 predominantly expresses in GBM mesenchymal subtype, and gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses reveal that CD44 positively coexpressed genes are closely related to glioma immunity. Moreover, CD44+ cells mainly distribute in perinecrotic region with high expression of immune factors. At single-cell resolution, only malignant tumor cells, tumor-associated macrophages (TAMs), and T cells express CD44 in GBM. CD44+ malignant tumor cells are in mesenchymal-1-like (MES1-like) cellular state, and CD44+ TAMs are in M2 phenotype. CD44+ T cells have high expression of both PD-1 and PD-L1. CD44 and its directly interacted inhibitory immunomodulators are upregulated in patients with nonresponder recurrent GBM treated with PD-1 blockade therapy.

Conclusion

Our work demonstrates that CD44, a new M2 TAM biomarker, is involved in immune suppressor and promote glioma progression in glioma microenvironment. These results expand our understanding of CD44-specific clinical and immune features in glioma.
Soluble Urokinase Receptor and Mortality in Kidney Transplant Recipients
Authors: Morath Christian , Hayek Salim S. , Döhler Bernd , Nusshag Christian , Sommerer Claudia , Zeier Martin , Reiser Jochen , Süsal Caner
Published: February 2022

Main problem: Soluble urokinase plasminogen activator receptor (suPAR) is an immunological risk factor for kidney disease and a prognostic marker for cardiovascular events.

Methods: We measured serum suPAR levels in a total of 1,023 kidney transplant recipients either before (cohort 1, n = 474) or at year 1 after transplantation (cohort 2, n = 549). The association of suPAR levels and all-cause and cardiovascular mortality was evaluated by multivariable Cox regression analysis.

Results: The highest suPAR tertile compared to the two lower tertiles had a significantly higher risk of all-cause mortality in both cohorts separately (cohort 1: hazard ratio (HR) 1.92, 95% confidence interval (CI) 1.20–3.08, p = 0.007; cohort 2: HR = 2.78, 95% CI 1.51–5.13, p = 0.001) and combined (n = 1,023, combined HR = 2.14, 95% CI 1.48–3.08, p < 0.001). The association remained significant in the subgroup of patients with normal kidney function (cohort 2: HR = 5.40, 95% CI 1.42–20.5, p = 0.013). The increased mortality risk in patients with high suPAR levels was attributable mainly to an increased rate of cardiovascular death (n = 1,023, HR = 4.24, 95% CI 1.81–9.96, p < 0.001).

Conclusion: A high suPAR level prior to and at 1 year after kidney transplantation was associated with an increased risk of patient death independent of kidney function, predominantly from cardiovascular cause.
Lessons and Recommendations from a Pentobarbital Shortage: US and Canada 2021
Authors: Cooney Kathleen , Titcombe Lianna
Published: February 2022

In 2021, a shortage in the supply of the euthanasia drug pentobarbital sodium affected animal care professionals around the world, including in the United States and Canada. Pentobarbital sodium is the drug of choice for companion animal euthanasia in both countries. The decreased availability of pentobarbital sodium affected a number of animal care industries, forcing conservation of the drug and the use of alternative methods and other agents to facilitate humane death for all manner of animal species. Veterinary medical groups, laboratory research institutions, and the animal sheltering industry worked together to identify the best path forward to maintain routine euthanasia practices and to protect the welfare of animals. This article aims to explore the reasons behind the shortage and to highlight the necessary responses and adjustments made in order to continue providing euthanasia services in North America. Recommendations for handling future pentobarbital shortages are included.
Robust Piezoelectric Coefficient Recovery by Nano-Inclusions Dispersion in Un-Poled PVDF–Ni0.5Zn0.5Fe2O4 Ultra-Thin Films
Authors: Nong Huyen T. T. , Nguyen Anh N. , Solard Jeanne , Gomez Andres , Mercone Silvana
Published: February 2022

This work aimed to study the influence of the hybrid interface in polyvinylidene fluoride (PVDF)-based composite thin films on the local piezoelectric response. Our results provide evidence of a surprising contradiction: the optimization process of the β-phase content using nano-inclusions did not correspond to the expected nanoscale piezoelectric optimization. A large piezoelectric loss was observed at the nanoscale level, which contrasts with the macroscopic polarization measurement observations. Our main goal was to show that the dispersion of metallic ferromagnetic nano-inclusions inside the PVDF films allows for the partial recovery of the local piezoelectric properties. From a dielectric point of view, it is not trivial to expect that keeping the same amount of the metallic volume inside the dielectric PVDF matrix would bring a better piezoelectric response by simply dispersing this phase. On the local resonance measured by PFM, this should be the worst due to the homogeneous distribution of the nano-inclusions. Both neat PVDF films and hybrid ones (0.5% in wt of nanoparticles included into the polymer matrix) showed, as-deposited (un-poled), a similar β-phase content. Although the piezoelectric coefficient in the case of the hybrid films was one order of magnitude lower than that for the neat PVDF films, the robustness of the polarized areas was reported 24 h after the polarization process and after several images scanning. We thus succeeded in demonstrating that un-poled polymer thin films can show the same piezoelectric coefficient as the poled one (i.e., 10 pm/V). In addition, low electric field switching (50 MV/m) was used here compared to the typical values reported in the literature (100–150 MV/m).
Dynamic Interplay between Cockayne Syndrome Protein B and Poly(ADP-Ribose) Polymerase 1 during Oxidative DNA Damage Repair
Authors: Lake Robert J. , Bilkis Rabeya , Fan Hua-Ying
Published: February 2022

Oxidative stress contributes to numerous diseases, including cancer. CSB is an ATP-dependent chromatin remodeler critical for oxidative stress relief. PARP1 is the major sensor for DNA breaks and fundamental for efficient single-strand break repair. DNA breaks activate PARP1, leading to the synthesis of poly(ADP-ribose) (PAR) on itself and neighboring proteins, which is crucial for the recruitment of DNA repair machinery. CSB and PARP1 interact; however, how CSB mechanistically participates in oxidative DNA damage repair mediated by PARP1 remains unclear. Using chromatin immunoprecipitation followed by quantitative PCR, we found that CSB and PARP1 facilitate each other’s chromatin association during the onset of oxidative stress, and that CSB facilitates PARP1 removal when the level of chromatin-bound CSB increases. Furthermore, by monitoring chromatin PAR levels using Western blot analysis, we found that CSB sustains the DNA damage signal initiated by PARP1, and may prevent PARP1 overactivation by facilitating DNA repair. By assaying cell viability in response to oxidative stress, we further demonstrate that PARP1 regulation by CSB is a major CSB function in oxidatively-stressed cells. Together, our study uncovers a dynamic interplay between CSB and PARP1 that is critical for oxidative stress relief.
Gangliosides and the Treatment of Neurodegenerative Diseases: A Long Italian Tradition
Authors: Fazzari Maria , Lunghi Giulia , Chiricozzi Elena , Mauri Laura , Sonnino Sandro
Published: February 2022

Gangliosides are glycosphingolipids which are particularly abundant in the plasma membrane of mammalian neurons. The knowledge of their presence in the human brain dates back to the end of 19th century, but their structure was determined much later, in the middle of the 1950s. From this time, neurochemical studies suggested that gangliosides, and particularly GM1 ganglioside, display neurotrophic and neuroprotective properties. The involvement of GM1 in modulating neuronal processes has been studied in detail by in vitro experiments, and the results indicated its direct role in modulating the activity of neurotrophin-dependent receptor signaling, the flux of calcium through the plasma membrane, and stabilizing the correct conformation of proteins, such as α-synuclein. Following, in vivo experiments supported the use of ganglioside drugs for the therapy of peripheral neuropathies, obtaining very positive results. However, the clinical use of gangliosides for the treatment of central neurodegeneration has not been followed due to the poor penetrability of these lipids at the central level. This, together with an ambiguous association (later denied) between ganglioside administration and Guillain-Barrè syndrome, led to the suspension of ganglioside drugs. In this critical review, we report on the evolution of research on gangliosides, on the current knowledge on the role played by gangliosides in regulating the biology of neurons, on the past and present use of ganglioside-based drugs used for therapy of peripheral neuropathies or used in human trials for central neurodegenerations, and on the therapeutic potential represented by the oligosaccharide chain of GM1 ganglioside for the treatment of neurodegenerative diseases.
Identification of Novel Mitochondrial Pyruvate Carrier Inhibitors by Homology Modeling and Pharmacophore-Based Virtual Screening
Authors: Hegazy Lamees , Gill Lauren E. , Pyles Kelly D. , Kaiho Christopher , Kchouk Sophia , Finck Brian N. , McCommis Kyle S. , Elgendy Bahaa
Published: February 2022

The mitochondrial pyruvate carrier (MPC) is an inner-mitochondrial membrane protein complex that has emerged as a drug target for treating a variety of human conditions. A heterodimer of two proteins, MPC1 and MPC2, comprises the functional MPC complex in higher organisms; however, the structure of this complex, including the critical residues that mediate binding of pyruvate and inhibitors, remain to be determined. Using homology modeling, we identified a putative substrate-binding cavity in the MPC dimer. Three amino acid residues (Phe66 (MPC1) and Asn100 and Lys49 (MPC2)) were validated by mutagenesis experiments to be important for substrate and inhibitor binding. Using this information, we developed a pharmacophore model and then performed a virtual screen of a chemical library. We identified five new non-indole MPC inhibitors, four with IC50 values in the nanomolar range that were up to 7-fold more potent than the canonical inhibitor UK-5099. These novel compounds possess drug-like properties and complied with Lipinski’s Rule of Five. They are predicted to have good aqueous solubility, oral bioavailability, and metabolic stability. Collectively, these studies provide important information about the structure-function relationships of the MPC complex and for future drug discovery efforts targeting the MPC.
Therapeutic Effects of Inhaled Nitric Oxide Therapy in COVID-19 Patients
Authors: Kamenshchikov Nikolay O. , Berra Lorenzo , Carroll Ryan W.
Published: February 2022

The global COVID-19 pandemic has become the largest public health challenge of recent years. The incidence of COVID-19-related acute hypoxemic respiratory failure (AHRF) occurs in up to 15% of hospitalized patients. Antiviral drugs currently available to clinicians have little to no effect on mortality, length of in-hospital stay, the need for mechanical ventilation, or long-term effects. Inhaled nitric oxide (iNO) administration is a promising new non-standard approach to directly treat viral burden while enhancing oxygenation. Along with its putative antiviral affect in COVID-19 patients, iNO can reduce inflammatory cell-mediated lung injury by inhibiting neutrophil activation, lowering pulmonary vascular resistance and decreasing edema in the alveolar spaces, collectively enhancing ventilation/perfusion matching. This narrative review article presents recent literature on the iNO therapy use for COVID-19 patients. The authors suggest that early administration of the iNO therapy may be a safe and promising approach for the treatment of COVID-19 patients. The authors also discuss unconventional approaches to treatment, continuous versus intermittent high-dose iNO therapy, timing of initiation of therapy (early versus late), and novel delivery systems. Future laboratory and clinical research is required to define the role of iNO as an adjunct therapy against bacterial, viral, and fungal infections.
Reliability of Biodegradation Measurements for Inhibitive Industrial Wastewaters
Authors: Prokkola Hanna , Heponiemi Anne , Pesonen Janne , Kuokkanen Toivo , Lassi Ulla
Published: February 2022

Industrial wastewaters may contain toxic or highly inhibitive compounds, which makes the measurement of biological oxygen demand (BOD) challenging. Due to the high concentration of organic compounds within them, industrial wastewater samples must be diluted to perform BOD measurements. This study focused on determining the reliability of wastewater BOD measurement using two different types of industrial wastewater, namely pharmaceutical wastewater containing a total organic carbon (TOC) value of 34,000 mg(C)/L and industrial paper manufacturing wastewater containing a corresponding TOC value of 30 mg(C)/L. Both manometric respirometry and the closed-bottle method were used in the study, and the results were compared. It was found that the dilution wastewaters containing inhibitive compounds affected BOD values, which increased due to the decreased inhibiting effect of wastewater pollutants. Therefore, the correct BOD for effluents should be measured from undiluted samples, while the diluted value is appropriate for determining the maximum value for biodegradable organic material in the effluent. The accuracy of the results from the blank samples was also examined, and it was found that the readings of these were different to those from the samples. Therefore, the blank value that must be subtracted may differ depending on the sample.
Totally Excited about Moving Mobility and Exercise (TEAM Me): A Successful Multidisciplinary Exercise Quality Improvement Initiative for Pediatric and Young Adult Oncology and Stem Cell Transplant Inpatients
Authors: Shaw Angela M. , Robert Rhonda , Kresta Kimberly , Andersen Clark R. , Lewis Betsy , Maetzold Brittni , Valderrama Raymund , Cion Ian , Tewari Priti
Published: February 2022

Background: Pediatric, adolescent and young adult (PAYA) patients are less active than their healthy counterparts, particularly during inpatient stays. Methods: We conducted a quality improvement initiative to increase activity levels in patients admitted to our pediatric oncology and cellular therapy unit using a Plan-Do-Study-Act (PDSA) model. An interdisciplinary team was assembled to develop an incentive-based inpatient exercise and activity program titled Totally Excited About Moving Mobility and Exercise (TEAM Me). As part of the program, patients were encouraged by their care team to remain active during their inpatient stay. As an additional incentive, patients earned stickers to display on TEAM Me door boards along with tickets that could be exchanged for prizes. Activity was assessed by documentation of physical therapy participation, tests of physical function, and surveys of staff perceptions of patient activity levels, motivations, and barriers. Results: Compared to baseline, patient refusals to participate in physical therapy decreased significantly (24% vs. 2%) (p < 0.02), and staff perceptions of patient motivation to stay active increased from 40% to 70% in the post implementation period. There were no changes in physical function tests. Conclusions: An incentive-based exercise program for young oncology inpatients greatly improved patient activity levels, participation in physical therapy and influenced professional caregivers’ beliefs.
A Longitudinal 3D Investigation on Facial Similarity among Two Monozygotic Twins in Their First Childhood: An Application of the 3D-3D Facial Superimposition Technique
Authors: Gibelli Daniele M. , Cappella Annalisa , Dolci Claudia , Rosati Riccardo , Bedoni Marzia , Sforza Chiarella
Published: February 2022

Children affected by orofacial disorders mix functional alterations with morphological problems, and suitable techniques should be devised for their analysis. Stereophotogrammetry and 3D-3D facial superimposition have already proven to reliably assess morphological differences even between twin siblings, separating the effect of genetic and environmental factors. However, little information is available about twin babies. We longitudinally analyzed a couple of healthy monozygotic twin sisters aged 6 months to 5 years (height time points). The entire 3D facial models of the two sisters were registered according to the least point-to-point distance, and the relevant RMS (root mean square) distance between the facial models was calculated at each time and compared with reference data recorded from adult twins (Mann-Whitney test, p < 0.05). RMS values in the twin sisters were on average 1.18 ± 0.21 mm, and 1.86 ± 0.53 mm in adults, with a significant difference (p < 0.01). Results showed that twins are more similar in early childhood when environmental factors are supposed to have not influenced facial morphology sufficiently. Additionally, the technique seems adequate to detect even small differences: the faces of the twin sisters were not fully identical. 3D-3D facial superimposition techniques can objectively quantify facial dissimilarity even in monozygotic twins. The method may be applied to the faces of twins discordant for some orofacial and maxillofacial pathology and potentially separate genetic and environmental factors.
Knowledge about Hand Hygiene and Related Infectious Disease Awareness among Primary School Children in Germany
Authors: Klar Kristin , Knaack Dennis , Kampmeier Stefanie , Hein Anna Katharina , Görlich Dennis , Steltenkamp Siegfried , Weyland Ulrike , Becker Karsten
Published: February 2022

Hand hygiene is a cornerstone of infection prevention. However, few data are available for school children on their knowledge of infectious diseases and their prevention. The aim of the study was to develop and apply a standardized questionnaire for children when visiting primary schools to survey their knowledge about infectious diseases, pathogen transmission and prevention measures. Enrolling thirteen German primary schools, 493 questionnaires for grade three primary school children were included for further analyses, comprising 257 (52.1%) girls and 236 (47.9%) boys with an age range of 8–11 years. Out of 489 children, 91.2% participants indicated that they knew about human-to-human transmissible diseases. Of these, 445 children responded in detail, most frequently mentioning respiratory and gastrointestinal diseases, followed by childhood diseases. Addressing putative hygiene awareness-influencing factors, it was worrisome that more than 40.0% of the children avoided visiting the sanitary facilities at school. Most of the children (82.9%) noted that they did not like to use the sanitary facilities at school because of their uncleanliness and the poor hygienic behavior of their classmates. In conclusion, basic infection awareness exists already in primary school age children. Ideas about the origin and prevention of infections are retrievable, however, this knowledge is not always accurate and adequately contextualized. Since the condition of sanitary facilities has a strong influence on usage behavior, the child’s perspective should be given more consideration in the design and maintenance of sanitary facilities.
Right Pulmonary Artery Originating from Ascending Aorta (Hemitruncus Arteriosus) with VACTERL Association in a Neonate: A Case Report
Authors: Shin Byeong-Su , Kim Taehong , Lee Hyoung Doo , Ko Hoon , Byun Joung-Hee
Published: February 2022

Vertebral, anal, cardiac, tracheo-esophageal fistula, renal and limb (VACTERL) association is defined as a condition including at least three of the above-mentioned anomalies in the same infant. Several cardiac defects that have been reported as a part of the VACTERL association are ventricular and atrial septal defects, hypoplastic left heart syndrome, transposition of the great arteries and tetralogy of Fallot. Anomalous origin of pulmonary artery (AOPA) from the ascending aorta is an unusual and critical cardiovascular anomaly, which frequently involves the right pulmonary artery (RPA). A male neonate was delivered by normal spontaneous vaginal delivery at 39 weeks and 3 days gestation, weighting 2660 gm. He was diagnosed with VACTERL association with five abnormalities: vertebral abnormalities, anal atresia, cardiovascular anomaly (right pulmonary artery originating from ascending aorta), tracheo-esophageal fistula and renal anomalies. AOPA origination from ascending aorta as part of the VACTERL association in a neonate is a rare congenital cardiovascular malformation. Here we present a rare case of RPA originating from the ascending aorta seen with VACTERL association in a neonate.
Microstructural Analysis of Terbium Doped Zirconia and Its Biological Studies
Authors: Veerachamy Suganthan , Rajagopal Sivakumar
Published: February 2022

Zirconia has its place in the biomedical industry because of its mechanical strength, bio-inertness, and physiochemical properties. Zirconia was synthesized and doped with Terbium (Tb), a lanthanide that was reported to show a photoluminescence property, which was a major characteristic for carcinogenic studies. Zirconia and Tb doped Zirconia were synthesized using the co-precipitation technique and were sintered at a temperature ranging from 900 to 1200 °C. The Zirconia sample and Tb doped Zirconia were thus studied for structural diversities using the X-ray powder diffraction technique (XRD), FTIR, FE-SEM, and TEM. From XRD, Zirconia phase transformation from monoclinic to tetragonal phase was observed, which signified limited fracture, elasticity, and crack formation. It was evident that Terbium stabilized the tetragonal phase of Zirconia, which reportedly shows mechanical properties, which include fracture toughness and flexural strength. The particle size of the Zirconia was comparatively more than the Tb doped Zirconia. The particle size of Zirconia ranged between 176 nm and 393 nm and the particle size of Tb doped Zirconia ranged between 110 nm and 343 nm. The biocompatibility of both the samples was tested using an Mg-63 cell line, and the cell viability was observed to be higher in Tb doped Zirconia when compared to the undoped Zirconia sample.
Immunotherapy in Thoracic Malignancies: New Treatment and New Hope
Authors: Melosky Barbara
Published: February 2022

Over these last two pandemic years, we have all experienced profound changes in how we practice, how we work, and how we live [...]
The Carnot Cycle and Heat Engine Fundamentals and Applications II
Authors: Feidt Michel
Published: February 2022

This editorial introduces the second Special Issue entitled “Carnot Cycle and Heat Engine Fundamentals and Applications II” https://www [...]
A Bayesian Approach to the Estimation of Parameters and Their Interdependencies in Environmental Modeling
Authors: Albert Christopher G. , Callies Ulrich , von Toussaint Udo
Published: February 2022

We present a case study for Bayesian analysis and proper representation of distributions and dependence among parameters when calibrating process-oriented environmental models. A simple water quality model for the Elbe River (Germany) is referred to as an example, but the approach is applicable to a wide range of environmental models with time-series output. Model parameters are estimated by Bayesian inference via Markov Chain Monte Carlo (MCMC) sampling. While the best-fit solution matches usual least-squares model calibration (with a penalty term for excessive parameter values), the Bayesian approach has the advantage of yielding a joint probability distribution for parameters. This posterior distribution encompasses all possible parameter combinations that produce a simulation output that fits observed data within measurement and modeling uncertainty. Bayesian inference further permits the introduction of prior knowledge, e.g., positivity of certain parameters. The estimated distribution shows to which extent model parameters are controlled by observations through the process of inference, highlighting issues that cannot be settled unless more information becomes available. An interactive interface enables tracking for how ranges of parameter values that are consistent with observations change during the process of a step-by-step assignment of fixed parameter values. Based on an initial analysis of the posterior via an undirected Gaussian graphical model, a directed Bayesian network (BN) is constructed. The BN transparently conveys information on the interdependence of parameters after calibration. Finally, a strategy to reduce the number of expensive model runs in MCMC sampling for the presented purpose is introduced based on a newly developed variant of delayed acceptance sampling with a Gaussian process surrogate and linear dimensionality reduction to support function-valued outputs.
Model to Predict Quality of Photovoltaic Panels Considering Customers’ Expectations
Authors: Pacana Andrzej , Siwiec Dominika
Published: February 2022

The perspective of reducing negative climate changes in the area of production of electricity is beneficial mainly for photovoltaic panels (PV). In this case, qualitative–ecological interactions arise, which should be verified to properly select PV. It refers to the analysis of customers’ expectations of the utility of photovoltaic panels and their impact on the landscape (environments). Therefore, the purpose of the article was to propose a model to predict the quality of photovoltaic panels considering the expectations of the customers. According to the SMART(-ER) method, the purpose of the analysis was determined. Then, using brainstorming (BM), the criteria of PV were determined in groups: technical, utility, and aesthetic. The customer expectations were then obtained by questionnaire with the technique with the method of comparison in pairs and Likert scale. Customer expectations were initially verified using the AHP method, after which the key PV criteria of PV were selected. The relations between these criteria were then determined by the DEMATEL method. According to customer expectations, the quality of PV was calculated. The Weighted Product Model (WPM) was used this purpose. As a result, the best photovoltaic panel was predicted for the best PV for the customer by using the relative state scale. The developed model can be used by any entity for any photovoltaic panel and by individual personalized criteria for the customer and other interested parties. The originality of this model is the integration of selected techniques in such a way as to provide them with the greatest satisfaction after choosing a PV based on customer expectations.
Sensor Technology Options for Municipal Solid Waste Characterization for Optimal Operation of Waste-to-Energy Plants
Authors: Muri Harald Ian D. I. , Hjelme Dag Roar
Published: February 2022

Reuse, refurbishing, and recycling are the most sustainable options for handling waste materials. However, for municipal solid waste (MSW) that is highly heterogenic, crude, contaminated, and decrepit, thermal conversion in waste-to-energy (WtE) plants is an option. In such plants, the fuel quality of MSW is difficult to predict and the substantial changes expected are challenging for incineration stability. Development of new online sensor technologies for monitoring waste properties prior to incineration is therefore needed. Sensors may contribute to increase WtE process stability, as well as reducing the probability of incineration stops or emissions exceeding legal limits. In this work, the operating principles of potential sensor systems for waste monitoring are categorized and assessed to be implemented for providing parameters for process control or indicators for process alarms in the waste incineration process. For transmissive settings, the use of inductance and hard X-ray sensors are most promising, whereas for reflective settings, utilization of photonic, inductive, soft and hard X-ray, as well as low-frequency radiowave sensors, are most promising. The analytic capacity of single-point measurements with inductance, radiowave, photonic, or X-ray sensors are limited to providing indicators for process alarms, whereas spectral imaging with X-ray or photonic techniques are feasible for providing parameters for both process control and indicators for process alarms. The results obtained in this sensor assessment will be important as a first step in guiding the evolution of monitoring waste properties in the WtE industry to increase repeatability, performance of energy production, and manual labor safety in controlling the waste incineration.
Optimal Tradeoff between MPP and Stability of a PV-Based Pumping System
Authors: Souhail Wahid , Alsharif Sameer , Ahmed Irfan , Khammari Hedi
Published: February 2022

This paper presents a novel algorithm to pick PV-based pumping system operating points that simultaneously achieve maximum delivered power and optimized stability. We present an in-depth analysis of operating point dynamics and shape the PV output current and voltage parameter plans. Accordingly, we draw the power bifurcation diagram with all possible operating points. Our proposed algorithm picks the power operating point midway between two consecutive stable points and far enough from the stability boundary to assure system safety. We validated our methodology successfully by numerical simulation based on speculative evidence using MATCON/MATLAB/SimPowerSystems blocks. In addition, we compared the proposed algorithm with P&O MPPT algorithm, and the results verified the reliability of our proposed algorithm to deliver maximum stable power.
Reduction of the Information Gap Problem in Industry 4.0 Projects as a Way to Reduce Energy Consumption by the Industrial Sector
Authors: Wachnik Bartosz , Kłodawski Michał , Kardas-Cinal Ewa
Published: February 2022

Reducing energy consumption should be treated as crucial for contemporary information and communication technology (ICT) projects under conditions of Industry 4.0. This research proposes a wider look at the factors influencing the success of ICT industry projects, considering not only technological and procedural conditions or implementation methods but also information and competency resources, thus allowing for correct decisions to be taken during project implementation. The article analyzes the information gap in Industry 4.0 projects completed in enterprises based in Poland, following the concept of sustainable development and minimization of energy consumption. The research was completed between 2018 and 2021 in medium enterprises, and the result is a qualitative characteristic of the information gap in ICT projects from the client’s perspective. The research can help develop a complete methodology for Industry 4.0 ICT projects to limit the level of uncertainty and risk while reducing energy consumption.
A New Decision Process for Choosing the Wind Resource Assessment Workflow with the Best Compromise between Accuracy and Costs for a Given Project in Complex Terrain
Authors: Barber Sarah , Schubiger Alain , Koller Sara , Eggli Dominik , Radi Alexander , Rumpf Andreas , Knaus Hermann
Published: February 2022

In wind energy, the accuracy of the estimation of the wind resource has an enormous effect on the expected rate of return of a project. For a given project, the wind resource assessor is faced with a difficult choice of a wide range of simulation tools and workflows with varying accuracies (or “skill”) and costs. There is currently no guideline or process available in the industry for helping with the decision of the most “optimal” choice—and this is particularly challenging in mountainous (or “complex”) terrain. In this work, a new decision process for selecting the Wind Resource Assessment (WRA) workflow that would expect to deliver the best compromise between skill and costs for a given wind energy project is developed, with a focus on complex terrain. This involves estimating the expected skill and cost scores using a set of pre-defined weighted parameters. The new process is designed and tested by applying seven different WRA workflows to five different complex terrain sites. The quality of the decision process is then assessed for all the sites by comparing the decision made (i.e., choice of optimal workflow) using the expected skill and cost scores with the decision made using the actual skill and cost scores (obtained by comparing measurements and simulations at a validation location). The results show that the decision process works well, but the accuracy decreases as the site complexity increases. It is therefore concluded that some of the parameter weightings should be dependent on site complexity. On-going work involves collecting more data from a large range of sites, implementing measures to reduce the subjectivity of the process and developing a reliable and robust automated decision tool for the industry.
Computational Approach of Charging and Discharging Phases in a Novel Compact Solar Collector with Integrated Thermal Energy Storage Tank: Study of Different Phase Change Materials
Authors: Koukou Maria K. , Pagkalos Christos , Dogkas George , Vrachopoulos Michail Gr. , Douvi Eleni , Caouris Yannis G. , Papadopoulos Polykarpos
Published: February 2022

A numerical study was carried out to investigate charging and discharging processes of different phase change materials (PCMs) used for thermal storage in an innovative solar collector, targeting domestic hot water (DHW) requirements. The aim was to study PCMs that meet all application requirements, considering their thermal performance in terms of stored and retrieved energy, outlet temperatures, and water flow rate. Work was carried out for three flat-plate solar panels of different sizes. For each panel, a PCM tank with a heat exchanger was attached on the back plate. Simulations were conducted on a 2D domain using the enthalpy–porosity technique. Three paraffin-based PCMs were studied, two (A53, P53) with phase-change temperatures of approximately 53 °C and one of approximately 58 °C (A58H). Results showed that, during charging, A58H can store the most energy and A53 the least (12.30 kWh and 10.54 kWh, respectively, for the biggest unit). However, the biggest unit, A58H, takes the most time to be fully charged, i.e., 6.43 h for the fastest feed rate, while the A53 unit charges the fastest, at 4.25 h. The behavior of P53 lies in between A53 and A58H, considering stored energy and charging time. During discharging, all PCMs could provide an adequate DHW amount, even in the worst case, that is, a small unit with a high hot water consumption rate. The A58H unit provides hot water above 40 °C for 10 min, P53 for 11 min, and A53 for 12 min. The DHW production duration increased if a bigger unit was used or if the consumption rate was lower.
Economic and Environmental Potential of Large-Scale Renewable Synthetic Jet Fuel Production through Integration into a Biomass CHP Plant in Sweden
Authors: Fagerström Anton , Abdelaziz Omar , Poulikidou Sofia , Lewrén Adam , Hulteberg Christian , Wallberg Ola , Rydberg Tomas
Published: February 2022

The potential of bio-electro-jet fuel (BEJF) production with integration into an existing biomass-based combined heat and power (CHP) facility was investigated. The BEJF is produced via Fischer–Tropsch (F–T) synthesis from biogenic CO2 and H2 obtained by water electrolysis. Techno-economic (TEA)- and life. cycle (LCA)- assessments were performed to evaluate the production cost and environmental impact of the BEJF production route. The BEJF mass fraction reached 40% of the total F–T crude produced. A reduction of 78% in heating demands was achieved through energy integration, leading to an increase in the thermal efficiency by up to 39%, based on the F–T crude. The total production cost of BEJF was in the range of EUR 1.6–2.5/liter (EUR 169–250/MWh). The GWP of the BEJF was estimated to be 19 g CO2-eq per MJ BEJF. The reduction potential in GWP in contrast to the fossil jet baseline fuel varied from 44% to more than 86%. The findings of this study underline the potential of BEJF as a resource-efficient, cost-effective, and environmentally benign alternative for the aviation sector. The outcome is expected to be applicable to different geographical locations or industrial networks when the identified influencing factors are met.
Turbulence and Fluid Mechanics
Authors: Malecha Ziemowit
Published: February 2022

This Special Issue of Energies features 11 scientific papers on the subject of turbulence and fluid mechanics [...]
Research on Air-Flow-Field Characteristics and Structural Optimization of the Guide Channels of the Autoclave
Authors: Sun Yanan , Gao Dianrong , Zhang Zongyi , Guan Tianyuan , Chen Bo , Liang Yingna , Zhao Jianhua , Ji Yun
Published: February 2022

In order to solve the problem of uneven air inlet flow in the guide channel of autoclave, three optimization schemes for the guide plate were proposed. The flow field in the guide channels of autoclave was simulated and analyzed by the realizable k-epsilon turbulence model and dynamic boundary method. The results show that the three optimization schemes have a certain effect on solving the problem of uneven air inlet flow in each guide channel, but some of them also have some negative effects. The integration of the three optimization schemes effectively increases the total air inlet flow of the guide channels; the increase ratio reaches 4.15%, improves the flow-field characteristics at the outlet of the guide channels and greatly reduces the difference in the air inlet flow in the left and right guide channels; the difference ratio drops from 62.61% to 5.37%.
E-Waste and End-of-Life Vehicles Management and Circular Economy Initiatives in Romania
Authors: Modoi Oana-Cristina , Mihai Florin-Constantin
Published: February 2022

E-waste and end-of-life vehicles (ELVs) are fast-growing waste streams in the EU and beyond that require specific collection and treatment activities to avoid environmental pollution and resource depletion fed by the linear economy model. This paper aims to investigate the links between e-waste and ELVs streams and the circular economy approach of the EU. Romania is examined as a relevant case study for the central and eastern European Region regarding: (i) the current e-waste and ELVs management deficiencies and challenges in line with circular economy principles promoted by EU; (ii) analysis of E-waste and ELVs flows data; and (iii) best circular economy initiatives related to e-waste and ELVs in Romania, including the opportunity to create new jobs in treatment activities that the simple operations from the first stages of e-waste recycling can produce locally and regionally in Romania. This work points out the current knowledge gaps and future research directions for these special waste streams in Romania and beyond.