bluuebunny/crossref_metadata_2025 huggingface dataset:
Housing Tenure and the Risk of Mortality among Older Adults in Japan: Are Those Living in Public Rental Housing Healthier than Those Living in Private Rental Housing? A 9-Year Cohort Study from the JAGES
Authors: Koga Chie , Saito Tami , Hanazato Masamichi , Kondo Naoki , Saito Masashige , Ojima Toshiyuki , Kondo Katsunori
Published: June 2023

Housing tenure is an important aspect to determine health. However, even though renters tend to have more socioeconomic disadvantages than homeowners, the mortality risk between private and public renters compared with homeowners remains unclear. Japanese public rented housing, such as the Urban Renaissance Agency, has been developed for supplying an adequate living environment since 1950s. This study aimed to examine the mortality risk among older Japanese residents living in private and public rented houses compared with those living in owner-occupied houses using 9-year follow-up data. This study drew upon a 9-year follow-up of participants in the Japan Gerontological Evaluation Study, a population-based cohort study of Japanese independent adults aged ≥65 years. Mortality from 2010 to 2019 was analyzed for 44,007 respondents. Housing tenure was defined by a questionnaire. Cox regression models were used for calculating the hazard ratio for mortality. Bonferroni correction was used to account for multiple testing between rental houses. Overall, 10,638 deaths occurred during the follow-up period. Compared with housing owners, all rental housing groups had a significantly higher risk of mortality. Among renters, participants who lived in public rental housing had the lowest risk of mortality even after adjusting for sociodemographic characteristics, health status, social status, and environmental status. Multiple testing among renters with Bonferroni correction showed that public renters had 0.80 times (p = 0.0001) lower mortality risk than private renters. Although Japanese older adults living in public rental housing had a higher mortality risk than homeowners, this risk was lower than that among private renters. A positive neighborhood environment based on well-planned urban development may have contributed to this result. The results suggest that planned urban development lowers the risk of mortality in older renters in Japan.
Expression profile analysis of muscle growth regulation genes and effects of water flow stress on their expression levels in zebrafish
Authors: Yuan Xiudan , Tao Leiting , Hu Xiaoli , Lin Ruoyu , Yang Jingping , Feng Mengzhe , Peng Mei , Liu Wenbin , Xiao Yamei
Published: June 2023

Exercise can have beneficial effects on fish. However, there is few studies on the expression profile analysis of muscle growth regulation genes and impact of water flow stress on expression levels of the muscle genes in fish. In this study, myogenic regulatory genes (MyoD), myostatin-regulated genes (Mstnb), myoblast development-related genes (DesminandMYHC)were displayed high expression in muscle tissues of adult zebrafish.MyoD,MyoG, MRF4andMYHCare higher expression at the muscle effect stage embryos. And we explore that the 30 days old is critical muscle growth period in zebrafish. Furthermore, water flow stress can enhance the expression levels of myogenic regulatory factors (eg.MyoD, MyoG) and myoblast development-related genes (Pax7, Desmin) in the zebrafish trunk dorsal muscle, while the mRNA levels of myostatin regulatory genes, such asMstnaandMstnb, are significantly down-regulated. Our results suggest that appropriate water flow stressing for 1–2 weeks could promote zebrafish muscle growth, while zebrafish may be in motor fatigue after four weeks of water flow stress. This research provides a foundation for further exploration of fish exercise physiology and adaptation, and is significant for fish farming and conservation.
Heat Conductance of the Quantum Hall Bulk
Authors: Heiblum Moty , Melcer Ron , Gil Avigail , Umansky Vladimir , Oreg Yuval , Stern Ady , Berg Erez
Published: June 2023

The Quantum Hall Effect (QHE) is the prototypical realization of a topological state of matter. It emerges from a subtle interplay between topology, interactions, and disorder. The disorder enables the formation of localized states in the bulk that stabilize the quantum Hall states with respect to the magnetic field and carrier density. Still, the details of the localized states and their contribution to transport remain beyond the reach of most experimental techniques. Here, we describe an extensive study of the bulk's heat conductance. Using a novel 'multi-terminal' device, we separate the longitudinal thermal conductance (due to bulk's contribution) κxx T from the two-terminal value κ2T T, by eliminating the contribution of the edge modes. We find that when the field is tuned away from the conductance plateau center, the electronic states of the bulk conduct heat efficiently while the bulk remains electrically insulating. For fragile fractional states, such as the non-Abelian ν=5/2, we observe a finite κxx T throughout the plateau. We identify the localized states as the cause of the finite κxx T and propose a theoretical model which qualitatively explains our findings.
Design, Synthesis, and Biological Evaluation of New Biaryl Derivatives of Cycloalkyl diacetamide Bearing Chalcone Moiety as type II c-MET Kinase Inhibitors
Authors: Salarinejad Somayeh , Seyfi Soheila , Hayashi Seiko , Moghimi Setareh , Toolabi Mahsa , Taslimi Parham , Firoozpour Loghman , Usui Takeo , Foroumadi Alireza
Published: June 2023

Many human cancers have been associated with the deregulation of the mesenchymal-epithelial transition factor tyrosine kinase (MET) receptor, a promising drug target for anticancer drug discovery. Herein, we report the discovery of a novel structure of potent chalcone-based derivatives type II c-Met inhibitors which are comparable to Foretinib (IC50 = 14 nM) as a potent reference drug. Based on our design strategy, we also expected an anti-tubulin activity for the compounds. However, the weak inhibitory effects on microtubules were confirmed by cell cycle analyses implicated that the observed cytotoxicity against HeLa cells probably was not derived from tubulin inhibition. Compounds 14q and 14k with IC50 values of 25 nM and 46 nM, respectively, demonstrated favorable inhibition of MET kinase activity, and desirable bonding interactions in the ligand-MET enzyme complex stability in molecular docking studies.
Bone transport using a unilateral versus circular external fixator over an intramedullary nail in the treatment of tibial bone defect caused by infection: a retrospective comparative study
Authors: Maimaiti Xiayimaierdan , Liu Kai , Yusufu Aihemaitijiang , Xie Zengru
Published: June 2023

Background
The purpose of the study was to compare the clinical efficacy of bone transport with either circular or unilateral external fixators over an intramedullary nail (EFOIN) in the treatment of tibial bone defects caused by infection.
Methods
Between May 2010 and January 2019, clinical and radiographic data were collected and analyzed for patients with bone defects caused by infection. Thirteen patients underwent bone transport using a unilateral external fixator over an intramedullary nail (Group A), while 12 patients were treated with a circular external fixator over an intramedullary nail (Group B). The bone and functional outcomes of both groups were assessed and compared using the Association for the Study and Application of the Method of the Ilizarov (ASAMI) criteria, and postoperative complications were evaluated according to the Paley classification.
Results
A total of 25 patients were successfully treated with bone transport using EFOIN, with a mean follow-up time of 31.63 ± 5.88 months. There were no significant statistical differences in age, gender, previous surgery per patient, duration of infection, DS, EFT, EFI, BUT, and follow-up time between Group A and Group B (P > 0.05). However, statistically significant differences were observed in operation time and intraoperative blood loss between the two groups (P < 0.05). The excellent and good rate of bone and functional results were higher in Group A compared to Group B (76.9% vs 75% and 84.6% vs 58.3%). Statistically significant differences were observed in functional results and complication per patient between the two groups (P < 0.05).
Conclusions
Bone transport using a combined technique of EFOIN proved to be an effective method in treating tibial bone defects caused by infection. In comparison to circular external fixators, bone transport utilizing a unilateral external fixator over an intramedullary nail resulted in fewer complications and better functional outcomes.
Associating White Matter Microstructural Integrity and Improvements in Reactive Stepping in People with Parkinson’s Disease
Authors: Andrew Sean Monaghan , Ofori Edward , Brett W Fling , Daniel S. Peterson
Published: June 2023

Reactive steps are rapid responses after balance challenges. People with Parkinson's Disease demonstrate impaired reactive stepping, increasing fall risk. Although PwPD can improve steps through practice, the neural mechanisms contributing to improved reactive stepping in people with PD are poorly understood. This study investigated white-matter correlates of responsiveness to reactive step training in people with PD. Participants completed an eighteen-week multiple-baseline study consisting of two baseline assessments (B1 and B2) before training, a two-week, six-session training protocol, and two post-training assessments (immediate; P1) and two months after training (P2). Each assessment consisted of 3 backward reactive step trials. Outcomes included the anterior-posterior margin of stability, step length, and step latency. Tract-Based Spatial Statistics were performed to correlate white-matter microstructural integrity (fractional anisotropy and radial diffusivity) with retained improvements in reactive stepping at the two-month follow-up (P2–B2). Complete datasets were available from 22 participants. Greater retention of step length was associated with increased fractional anisotropy (better white-matter integrity) within the left anterior corona radiata (r = 0.54, p < 0.01), left posterior thalamic radiation (r = 0.54, p < 0.01), and right (r = 0.43, p = 0.04) and left (r = 0.0.40, p = 0.06) superior longitudinal fasciculi. Greater retention of step latency improvements was associated with lower radial diffusivity (greater white-matter integrity) within the left posterior (r = 0.60, p < 0.01) and anterior corona radiata (r = 0.61, p < 0.01). These findings highlight the importance of white-matter microstructural integrity in motor learning and retention processes in PD and may inform the development of targeted interventions to improve balance in people with PD.
Multifocal Metastatic Spread of Prostate Adenocarcinoma: A Case Report Involving Lung and Brain Infiltration
Authors: Bansro Varinder , Chhabra Gurdeep , Lee Heather , Parkash Jasmita , Siddiqi Sarwat
Published: June 2023

Background:
Prostate cancer is a prevalent malignancy in males, particularly in older individuals and non-Hispanic Black men. Adenocarcinomas represent most prostate cancers, while other histological types are less common. Metastases from prostate cancer primarily involve bones and lymph nodes, with isolated lung and brain metastases being extremely uncommon. Understanding prostate cancer's clinical characteristics and behavior with atypical metastatic patterns is crucial for accurate diagnosis and optimal treatment strategies.
Case Presentation:
We present a case of a 60-year-old patient with high-grade Gleason prostate cancer, initially presenting with negative PSA levels. Despite the absence of bone involvement, the patient developed metastases to both the lung and brain, representing an unusual spread pattern. Detailed clinical features, imaging findings, diagnostic workup, and treatment interventions are described to provide a comprehensive understanding of this exceptional case.
Conclusion:
This case report highlights the rarity and clinical significance of prostate cancer metastases to the lung and brain without bone involvement. Isolated lung and brain metastases from prostate cancer are infrequent occurrences, and their diagnosis and management pose considerable challenges. Clinicians should be aware of these potential metastatic patterns, especially when encountering unusual clinical presentations or imaging findings in prostate cancer patients. Further research and case reports are warranted to enhance our knowledge of these rare metastatic events and optimize treatment approaches for patients with prostate cancer and atypical metastases.
Effect of artificial lights on Aedes eggs in strata residential in Selangor, Malaysia: a field cluster randomized control trial
Authors: Ramli Lina Farhana , Saliluddin Suhainizam , Baharudin Mohd Rafee , Suli Zailiza , Ming Lau Sai
Published: June 2023

Background
Dengue fever remains the deadliest infectious disease in tropical and subtropical regions. Even though numerous vector control measures have been taken, dengue incidence has continued to rise in the country due to rapid urbanization, population increase, and vertical housing development. Few studies examine the association between light intensity and Aedes and dengue. This study assesses how artificial light interventions may affect Aedes population density and dengue incidence in strata residential buildings in Malaysia.
Methods
This study was a two-armed, single-blinded, parallel, stratified cluster-randomized trial conducted in epidemiology week (EW) 41 until EW 52 in 2022. Nine intervention sites were applied with artificial light and the standard operating procedure of dengue control. The Aedes density was measured using paddle ovitraps placed at the study sites weekly. The ovitrap index and egg density index were calculated for each site.
Results
The recovered ovitraps (50.2%) and positive ovitraps (50.3%) were higher among control sites than intervention sites. In both arm groups, positive ovitrap was the highest at a 1-month post-intervention follow-up compared to baseline and immediate post-intervention period. Among intervention sites, the total Aedes eggs were lowest during baseline (24.2%), meanwhile among control sites was during immediate post-intervention (25.2%). There was no significant difference in the ovitrap index between intervention and control sites in the study (β = -3.156, 95% CI: -10.151, 3.839, p = 0.368). Meanwhile, there was a statistically significant difference in egg density index between intervention and control sites (β = 12.607, 95% CI: 3.295, 21.918; p = 0.009).
Conclusion
Artificial light can serve as a novel approach in vector control for mitigating the transmission of Aedes-borne illnesses. This alternative method could supplement existing insecticide approaches or human behavioural prevention programs. Implementing an innovative device that integrates artificial light as a dengue control is a feasible solution in the future.
This study was registered under the Thai Clinical Trials Registry (TCTR) on April 3rd, 2023, with the identification number is TCTR20230403006
Investigation on sustainably developed concrete by valorizing granite waste as replacement of fine aggregates
Authors: Reddy Sudheer , Choudhary Sumit , Sharma Kul Vaibhav , Kishore P. Ravi , Kumar S. Anandha , Mamidala Rithwik
Published: June 2023

Concrete that uses waste from the granite industry as a mixing component consumes less natural aggregate and has fewer disposal issues. Impact of recycled granite particles on the characteristics of concrete is discussed in this paper. Investigations were conducted on concretes with 0.4 and 0.5 w/c ratios with various partial and complete substitution percentages of granite particles as natural sand by weight. More specifically, the percentages of replacement followed were 0% – 100% with an interval of 10% (i.e., 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, and 100%). The mechanical and durability tests enlisting compressive strength, flexural strength, split tensile strength and water penetration test, abrasion resistance test for mechanical parameters and durability parameters respectively were performed. Moreover, ultrasonic pulse velocity and rebound hammer test were also done to assess the mechanical property through non-destructive testing method. In comparison to nominal concrete, the tests revealed that presence of granite slurry had positive effect on the concrete's compressive strength upto 40% replacement for both the water cement ratios. However, the outcomes indicated that adding 50% of waste granite to concrete reduced its compressive and tensile strength, with the impacts being more intense in the case of higher replacements. Moreover, the presence of granite particles made fresh concrete less workable. The weakened intermediate region between aggregate and cement paste was seen in microstructure photographs of the concrete containing granite cutting waste.
Effects of spatiotemporal parameters and flexible corrugated structures on dragonfly aerodynamics
Authors: Wang YuPing , He Guoyi
Published: June 2023

The effects of unsteady motions of flapping flat plates and corrugated structures in different parameters are studied using fluid-solid coupling and overlapping grid methods. Based on the dragonfly's right forewing and right hindwing model, these actions include sweeping and pitching, take-off acceleration, and tandem wings cruising in the reverse phase at 180°. The results show that when the advance ratio J =0.36, the “inflow deflection” improves the aerodynamic force in two degrees of freedom compared to simple flapping. When considering only the impact of flexibility, the aerodynamic forces of flexible flat plates and corrugated structures are better than that of the rigid wing models. Considering the effect of corrugated structures, the lift of flexible corrugated wings diminishes, but more thrust is generated. From the perspective of vortex street, chain vortices materialize only in the downstroke stage, while the attachment effect of leading edge vortices is noticeable in several models. In the same phase flutter, the two wings combine to form a giant wing, which generates significant forward flight momentum. In anti-phase flapping mode, the series wings generate two lifts and two or three thrust peaks to attain the required forward flight speed while sustaining a high lift.
Circulating Tumour Cells Predict Recurrences and Survival in Head and Neck Squamous Cell Carcinoma Patients
Authors: Zhang Xi , Weeramange Chameera Ekanayake , Hughes Brett G. M. , Vasani Sarju , Liu Zhen Yu , Warkiani Majid , Hartel Gunter , Ladwa Rahul , Thiery Jean Paul , Kenny Liz , Breik Omar , Punyadeera Chamindie
Published: June 2023

Background
Patients with head and neck squamous cell carcinoma (HNSCC) are at high risk of developing locoregional recurrence and secondary cancers. Early prediction is crucial for improving outcomes. This study evaluates the prognostic and surveillance utilities of circulating tumour cells (CTCs) in post-treatment HNSCC patients.
Methods
Blood samples were collected from 154 HNSCC patients at baseline and follow-up time points and CTC was isolated with a microfluid device. Recurrence and death due to cancer were assessed during the follow-up period.
Results
In patients with HNSCC, the presence of CTCs at baseline was an independent predictor of recurrence (odds ratio = 1.55, p < 0.05) and death (odds ratio = 2.10, p < 0.01), even after adjusting for TNM or nodal stage. Patients with CTC at baseline experienced poorer survival outcomes (p < 0.0001). Additionally, our study found that patients with CTCs in a follow-up appointment were 2.5 times more likely to experience recurrence or death from HNSCC (p < 0.05) prior to their next clinical visit.
Conclusions
Our study highlights CTCs' potential as a prognostic marker for risk stratification in HNSCC patients. Early CTC detection enables precise risk assessment, guiding treatment adjustments and ultimately improving patient outcomes.
Intersektionalität und Perspektivenstruktur : Entwurf eines Modells für die Untersuchung von Intersektionalität in multiperspektivischen Erzähltexten
Authors: Prieske Lucas
Published: June 2023

Erzählte Welten als soziale Wirklichkeiten denken: Dieser Beitrag skizziert ein Modell zur Untersuchung von Intersektionalität in multiperspektivisch erzählten Texten. Multiperspektivität wird als Erzählform stark gemacht, die in der Lage ist, die Machtverhältnisse und Diskurse der außertextlichen Realität aus der Vogelperspektive zu reflektieren. Aus einem narratologischen Blickwinkel wird hier der Frage nachgegangen, welchen Mehrwert die intersektionale Untersuchung von literarischen Perspektivenstrukturen für eine intersektional orientierte Literaturwissenschaft bietet, und mit welchen Begriffen und Konzepten eine solche Untersuchung durchgeführt werden kann. Es geht darum, die strukturellen Verhältnisse zwischen Einzelperspektiven zu den (sozialen) Hierarchien ihrer fiktionalen Wirklichkeit in Bezug zu setzen und zu untersuchen, welche Perspektiven diese Wirklichkeit schaffen und welche außen vor bleiben. Am Schluss steht eine exemplarische Textanalyse von Sibylle Bergs Roman "Ein paar Leute suchen das Glück und lachen sich tot" (1997), die deutlich macht, wie die Beziehung zwischen Sozial- und Textstrukturen gedacht werden kann.
Intersektionale Figurenanalyse : Anknüpfungspunkte und Anregungen für eine intersektional ausgerichtete Figurenanalyse mit Praxisbeispiel
Authors: Podelo Julia
Published: June 2023

Der Beitrag widmet sich der Figurenanalyse als Bestandteil der Texterschließung im intersektional ausgerichteten Deutschunterricht und konzipiert ein konkretes methodisches Analyseverfahren, das intersektionale Fragestellungen bei der Figurenanalyse zu erarbeiten und darzustellen vermag. Über eine erste literaturdidaktische Fundierung der Figurenanalyse als Texterschließungsverfahren werden Anknüpfungspunkte zum Intersektionalitätsparadigma aufgezeigt Der Beitrag versteht sich als Vorschlag für eine mögliche kulturtheoretische Fundierung der Figurenanalyse durch das Intersektionalitätsparadigma, welches mit dem Kollektivansatz von Klaus P. Hansen und dessen Fortführung durch Jürgen Bolten zum fuzzy culture-Ansatz in Bezug gesetzt wird. Aus dieser theoretischen Verbindung wird ein konkretes Instrumentarium zur intersektional orientierten Figurenanalyse in literaturdidaktischen Settings entwickelt, das sich durch eine strukturierte visuelle Aufarbeitung intersektionaler Fragestellungen in Bezug auf literarische Figuren auszeichnet. Die folgenden Ausführungen bieten zunächst einen kurzen Überblick über die literarische Figur allgemein und ihre Merkmale sowie die Bedeutung der Figurenanalyse im Deutschunterricht, bevor letztere unter intersektionalen Gesichtspunkten beleuchtet und in ein konkretes Analyseinstrumentarium überführt wird. Dieses wird abschließend an Eleonora Hummels Roman "Die Fische von Berlin" beispielhaft erprobt.
Empathie und Ekpathie beim literarischen Lesen und ihre Bedeutung für einen intersektionalitätssensiblen Literaturunterricht
Authors: Olsen Ralph
Published: June 2023

Obwohl Empathie beim literarischen Lesen unstrittig eine äußerst bedeutsame Rolle spielt, ist sie ein in der Literaturdidaktik immer noch nicht theoretisch und empirisch ausreichend erforschter Bereich. Bisher noch so gut wie gänzlich unbeachtet ist dabei ein Phänomen, das eng und unmittelbar mit empathischen Prozessen zusammenhängt: Ekpathie. Hierbei handelt es sich um lesebezogene Aspekte, die möglicherweise auch auf Grund ihres beispielsweise aktiv zurückweisenden Charakters - Leser:innen nähern sich einer literarischen Figur bewusst und willentlich nicht - aus nahe liegenden Gründen in der Literaturdidaktik noch nicht grundlegend thematisiert wurden. Der vorliegende Beitrag skizziert ekpathische Prozesse beim Lesen literarischer Texte in theoretischer Hinsicht und veranschaulicht sie auf der Grundlage wirkungsästhetischer Überlegungen auch aus einer dezidiert intersektionalen Perspektive anhand eines jugendliterarischen Beispieltextes.
Survey of Xylella fastidiosa Infection in Prunus Germplasm in Gainesville, FL, USA
Authors: Matsumoto Gabriel O. , Febres Vicente J. , Harmon Philip F. , Chaparro José X.
Published: June 2023

The pathogen Xylella fastidiosa is a xylem-restricted, gram-negative bacterium that is known to cause diseases of many cultivated plant species. Recent outbreaks of X. fastidiosa diseases in Europe have brought attention to the impact of this pathogen, especially to perennial crops. Among the Prunus genus, X. fastidiosa is known to have a wide range of hosts, including plum, almond, peach, cherry, and apricot. Infected trees have reduced fruit quality, possibly resulting in unmarketable fruits, as well as reduced lifespan. There are no curative management options for X. fastidiosa diseases in Prunus; therefore, development of resistant or tolerant cultivars through breeding represents an efficient option to reduce the impact of this pathogen. In this context, the main objective of this study was to determine the occurrence of X. fastidiosa in germplasm of the Stone Fruit Breeding Program at the University of Florida located in Gainesville, FL, USA, under natural infection conditions. A total of 43 individuals representing 10 different genotypic groups within the Prunus genus were tested for the presence of X. fastidiosa. Additionally, we report a novel and easy sampling method using sawdust collected from tree trunks for the detection of this pathogen in Prunus and the development of an endogenous control for improving the diagnosis of this pathogen using real-time polymerase chain reactions. Our results showed a high incidence of X. fastidiosa in the germplasm tested, with more than 65% of the samples positive for the presence of the bacterial pathogen. However, X. fastidiosa was not detected in most of the P. mume samples tested, whereas almost all the P. mume × P. armeniaca hybrids were positive. Negative individuals were also identified in P. avium, P. campanulata, P. umbellata, and P. salicina × P. ceracifera. These trees have been planted in the field, exposed to natural infection for 4 to 11 years, and are considered to show field resistance. Finally, primers and probes based on the Prunus COX gene developed in this study can be used as an internal amplification control to enhance the interpretation of results of X. fastidiosa detection assays using sawdust samples.
Epidemiological survival predictors of cancer of the corpus uteri: a population-based analysis
Authors: Svetlakova A. V. , Gromov D. D. , Chemakina O. V. , Agayeva A. V. , Valkova L. E. , Dyachenko A. A. , Bogdanov D. V. , Valkov M. Yu.
Published: June 2023

Cancer of the corpus uteri (CCU) is one of the most common gynecological malignancies in high- and middleincome countries. The objective of the study was to evaluate the factors predicting survival in CCU patients over the period 2000-2021 using the data of population-based cancer registry of the Arkhangelsk region. Material and Methods. Cancer-specific survival (CSS) of patients with CCU for the period 2000-21 was evaluated using life tables and Kaplan-Mayer methods with a log-rank test. The Cox proportional hazards regression model was used to assess the effect of prognostic factors on survival time. Results. A total of 3272 cases were selected for the analysis. The 5-year survival rates improved from 70.6 % in 2000-04 to 75.6 % in 2015-19. In stage I, II, III, and IV CUN, the 5-year survival rates were 90.8 % (95 % CI 89.3-92.0 %), 71.1 (95 % CI 66.3-75.4 %), 46.7 (95 % CI 41.4-51.8 %), and 3.9 (95 % CI 1.5-7.5 %), respectively; p<0.001. In the multivariate regression model, for stage II, III, and IV CCU, the hazard ratios for death from cancer were respectively 2.69 (2.14-3.39), 5.73 (4.66-7.03), and 20.26 (16.13-25.44) compared to stage I. The risk of death from CCU was 2.0-2.7 times higher in patients with aggressive histological subtypes and sarcomas compared to that in patients with endometrioid adenocarcinoma; 2.0-2.8 times higher in patients older than 60 years compared to younger patients, and 1.3 times higher in rural patients compared to urban patients (p<0.05). There was no increase in the risk of death from CCU over the period of COVID-19 pandemic. Conclusion. In this population-based study, we have found that the survival of patients with CCU is significantly affected by age and place of residence, which may indicate a limited access of some patients to effective treatment and requires further analysis. No increased risk of death from CCU during the COVID-19 pandemic was found.
Crowding phenomenon in breast cancer as a prognostic factor
Authors: Krakhmal N. V. , Zavyalova M. V. , Vtorushin S. V. , Tashireva L. A. , Perelmuter V. M.
Published: June 2023

Purpose: to evaluate the crowding-induced morphological changes in invasive breast carcinoma and compare the data obtained with the parameters of the tumor progression. Material and Methods. The study group included 107 patients (mean age: 57.2 ± 11.2 years) who did not receive neoadjuvant chemotherapy. Breast cancer morphological and immunohistochemical images were studied. The histological type of breast cancer was determined according to WHO recommendations (The WHO Classification of Breast Tumors, 5th Edition, 2019). The study included only cases with invasive breast carcinoma of no specific type. Clinical parameters were assessed using the patients' medical history. Statistical analysis was carried out using the Statistica 10.0 program. A p-value of 0.05 or lower was considered statistically significant. Results. The phenomenon of crowding in breast cancer was shown to be associated with lymph node metastases, with intratumoral heterogeneity of particular importance. The phenomenon of crowding was morphologically confirmed in all cases (n=40) with lymph node metastases in solid tumors. In these solid tumor structures, a decrease in the expression level of the proliferative index Ki67 was observed. In tumor sites with the evidence of crowding phenomenon in solid structures with lymph node metastasis, positive expression of integrin β1 was less frequently observed. Conclusion. Te results obtained suggest that the mechanism that initiates the process of tumor cell invasion may be based on crowding and basal cell extrusion, while the patterns found are a manifestation of changes in cell properties with the acquisition of a higher potential for mobility and cell migration.
Early and long-term outcomes of liver resections: a single specialized center experience
Authors: Chichevatov D. A. , Kalentjev V. V. , Glukhov A. E. , Seliverstova O. M. , Rodina G. A. , Tsyganova M. V.
Published: June 2023

The purpose of the study was to evaluate the outcomes of a series of liver resections performed in a single regional specialized cancer center. Material and Methods. Eighty-nine patients underwent liver and/ or extrahepatic bile duct resections in the Penza Regional Oncology Hospital over the 8-year study period. Malignancies were observed in 81 patients. Extended liver resections (4 segments or more) were performed in 58 (65.2 %) cases. Results. Postsurgical morbidity and mortality rates were 31.5 % (28 of 89) and 6.7 % (6 of 89), respectively. Six of 10 patients with primary liver carcinomas were alive without evidence of disease progression at a follow-up time ranged from 1.0 to 76.7 months. Adjuvant chemotherapy (ACT) was the only predictor (HR=0.40; 95 % CI 0.16-0.98) of overall survival in patients with metastatic colorectal cancer (mCRC). The median survival time after liver resections for mCRC with or without ACT was 54.5 (95 % CI: 14.5-94.5) vs 21.8 months (95 % CI: 14.2-29.4), respectively. In mCRC patients with ACT, the 5-year overall survival rate was 44.8 ± 12.9 %. Conclusion. Primary hepatobiliary carcinomas and colorectal cancer liver metastases are the most common reasons for liver resections. A series of liver resections in a low-volume hospital is feasible with the achievement of good outcomes.
Assess the Knowledge Pregnant Women have on HIV/AIDS, Mother to Child Transmission of HIV/AIDS and How PMTCT Services are Utilized in a Tertiary Health Facility in the Gambia
Authors: Ninson Robert
Published: June 2023

Mother-to-child transmission (MTCT) is by far the largest source of HIV infection in children below the age of 15 years. The virus may be transmitted during pregnancy, child birth or breast feeding. Globally 2.7 million children under the age of 15 years have died of AIDS Over 9 in 10 were I infected by their mothers. Recently however, many interventions are available to reduce mother to child transmission, such as anti-retroviral drug and avoidance of breast feeding. To assess the knowledge pregnant women have on HIV/AIDS, mother to child transmission of HIV/AIDS and how PMTCT services are utilized in a tertiary health facility in The Gambia. A structured questionnaire was used to obtain data from 150 women that consecutively attended the antenatal clinic of Hands On Care. Approval was obtained from the Director of Hand On Care. Sexually active population (15 – 24yrs) constituted 34% whilst 72.0% were housewives. Myths and misconceptions of HIV/AIDS, 42.7% said mosquito bites can cause HIV; 25.3% said sharing of meals with infected person can transmit HIV. Utilization of PMTCT services was high with 92.7% tested for HIV. Out of those respondents 50.0% had ever discussed PMTCT services with their husband. Utilization of PMTCT services among pregnant women was high. However, knowledge on the causes and transmission of HIV was inadequate. Need to formulate policies aim at sensitizing women about the causes and transmission of HIV/AIDS. Promoting the uptake of PMTCT services will also go a long way reducing the transmission of unborn babies by infected mothers. Keywords: Antenatal Care; HIV/AIDS; Knowledge; Prevention of Mother to Child Transmission; Pregnant Wome; Utilization.
Appraisal of Health Sector Responses to Covid-19 at National and Sub-National Levels: Case Study of States with Highest Prevalence of Cases-Lagos, Kaduna and FCT Assessment of Health Sector Responses to Covid-19 at Selected States with Highest Prevalence of Cases
Authors: Oladejo John
Published: June 2023

The Covid-19 pandemic is the largest and longest outbreak in modern times, with socio-economic, political, and educational disruptions. This study was to appraise the level of efforts and the impact of these interventions in the health sector. A mixed methodology approach involving quantitative research techniques. The study revealed that there was generally a high level of awareness and good compliance to government policies and guidelines on Covid-19 regulations being highest in Lagos state compared to FCT and Kaduna state. The public perception of the use of facemask and its enforcement and handwashing practices by health facilities was rated high across the three states. Client education and public perception of Covid-19 counselling was different across the three states, being highest in Lagos in comparison to FCT and Kaduna. Hence the study recommended refreshers training of health workers on awareness creation and counselling of clients at all levels of care. Keywords: Assessment, Covid-19, Health system strengthening.
Quality Management of the Pre-Analytical Phase Errors: Monitoring and Way Forward
Authors: Cordelia Enyanwu Ofaka,
Published: June 2023

Inadequate quality management during laboratory analysis can increase errors, specimen rejection, and economic resources wastages. A laboratory quality management system (QMS) helps to streamline and coordinate all the processes and operations within the lab, ensuring that each step is well planned, controlled, and correctly performed. Quality management ensures that results are accurate, reliable, and obtained under a traceable process that can easily detect errors. The study aimed to investigate quality practice among laboratory workers during pre-analytical phase activities. Unexpected deviation from quality procedures consequently compromise laboratory test results, leading to patient mismanagement and patient safety risks. Analysis of results showed that 97.1% (340 respondents) were knowledgeable on quality management of pre-analytical phase, and 2.9% (10 respondents) were not. 99.1% (347respondents) agreed to availability of quality management materials and 0.9% (3 respondents) had no resources. 4.6% (16 respondents) do not practice quality management system at pre-analytical phase and 94.5% (334 respondents) practiced quality improvements. 3.4% (12 respondents) agreed that quality improvement is the responsibility of phlebotomist and field staff. 96.6% (338 respondents) agreed that quality management is the responsibility of everyone at the facility. There was maximum knowledge of quality management at the facility. Availability of quality management resources at the facility was standard. The practice of quality management was below standard. Facility requires training in quality management. It is recommended that quality management system be integrated into the curriculum of school of health technology to guide graduates at work. Keywords: Quality, Improvement, Patient, Management, System.
Engaging Private Nursery and Primary Schools to Facilitate Catch - up Vaccination in Kosofe Local Government Area Lagos State Nigeria
Authors: Adaora Isabella Odis
Published: June 2023

Vaccination is very important to improve population health throughout life – but despite strong evidence, it is misunderstood and undervalued. Catch-up vaccination aims to provide optimal protection against disease as quickly as possible by completing a person’s recommended vaccination schedule in the shortest but most effective time frame. This descriptive cross-sectional implementation Research was designed to solve problems for Covid–19 recoveries for routine immunization program in private Nursery and primary school in Kosofe Local Government Area Lagos (School-based intervention). The sample size of 135 was adopted with purposive sampling method from the target population. All data were coded, entered, cleaned, and then analyzed using the IBM PSPP. Children that missed vaccination were tracked out more (90) and vaccinated, demand generation with the help of vaccine demand pooling in school for secondary vaccines, the awareness of vaccine-preventable diseases were created more at different schools Parents Teachers Association's meetings. Implementation Research is one of the measures and a component in the Immunization Agenda 2030 (IA 2030) designed to achieve the Life course immunization. Creating awareness and sensitization is very important in schools, especially using the power of storytelling for positive change in vaccination uptake. There are parents who can afford to pay for secondary vaccines but don't have the information and there are parents who have the information but can't afford to pay for secondary vaccines due to economic hardship in Nigeria. We recommend that vaccine demand pooling in schools is championed to enable parents to afford secondary vaccines for their children. Keywords: Catch-up immunization, demand generation, life course, vaccine-preventable diseases, zerodose children.
Kuzbass in the West-Siberian Academic Environment (1885–1917)
Authors: Blinov Alexey V.
Published: June 2023

In the Russian Empire, Kuzbass was an administrative part of the Tomsk Province. However, the local education belonged to the West-Siberian District, which united the entire Asian Russia. Its development coincided with the launch of the Great Trans-Siberian Railroad and P. A. Stolypin’s agrarian reform. These events brought about serious changes in the local economy, demography, and mentality, which increased the role of education in the region. The region had no institutions of higher education, and the secondary schools were also scarce. The education was mostly represented by primary schools, which were subordinate to the Ministry of Public Education. The Mariinsk and Tomsk Provinces were in the focus of modernization processes: a lot of rural and urban schools were opened there. However, by 1917, the West-Siberian District was still short of schools, and some areas had no educational institution of any level.
Whose Carbon Capture? A Bit of Good News
Authors: Shafer Michael
Published: June 2023

Global policy, policy makers and government representatives in the OECD countries routinely ignore the potential role to be played by carbon sequestration from crop waste biochar made by poor smallholders in the developing world. This paper argues that this is a mistake and makes the case for the design, development and distribution of low-cost, low-tech biochar making equipment to the world’s poorest farmers living on small farms and possessing only widely and thinly spread biomass resources on rough terrain. It argues that paying attention to the crop wastes of poor farmers can reduce GHG and PM2.5 emissions considerably and contends that the private motivations that underpin this approach can replace the talk of large-scale social behavior change with a self-replicating system built on farmers’ envy.
MODERN FORMS OF ORGANIZING THE ACTIVITIES OF PRESCHOOL CHILDREN TO DEVELOP FINANCIAL LITERACY
Authors: Khovanskaia Alena Aleksandrovna , Iakhontova Tatiana Grigorevna , Bulanova Irina Nikolaevna
Published: June 2023

The relevance of the problem presented in the article is determined by the currently growing interest in the problem of the formation of financial literacy of preschool children, which is a reflection of the need to improve the financial literacy of the population. In 2018, a number of fundamental documents appeared that confirmed the seriousness of the intentions of the state authorities to increase the financial literacy of the population. These are the “Concept of the long-term socio-economic development of the Russian Federation” and the “Strategy for the development of the financial market of the Russian Federation until 2020”, where financial literacy is seen as a resource and condition for the development of the country.
Masculinidades em cena: uma análise de "Rainha Diaba" e "Madame Satã"
Authors: Silva Santos Jonatas Breno , Barreto Malta Renata
Published: June 2023

O cinema é um importante objeto de análise das Ciência Sociais, refletindo a cultura, as identidades e os papéis sociais. Descortinando as relações de gênero e as representações masculinas, diversos filmes atribuem papéis sexuais aos homens e agenciam as relações de poder em torno desses. Partindo dessa percepção, surge o interesse de investigar as masculinidades em personagens gays nos filmes brasileiros, mais precisamente em “Rainha Diaba” (1974) e “Madame Satã” (2002), nos quais os protagonistas estão inseridos em um contexto de subalternidade, marginalidade, desvio e ruptura social. Assim, esta pesquisa visa descortinar como os protagonistas de ambos os filmes são representados no que concerne aos territórios de gênero e outros marcadores como raça, etnia e classe. Para tanto, será utilizado o protocolo de “análise de imagens e movimentos” da pesquisadora Diana Rose. Ao final, espera-se contribuir para os estudos relacionados ao campo da representação no cinema.
Projetando Questões de Género no Cinema Vernacular Guineense
Authors: Laranjeiro Catarina
Published: June 2023

A produção cinematográfica e audiovisual vernacular na Guiné-Bissau, viral entre os seus habitantes, está a crescer exponencialmente. Retratando eventos quotidianos, são habitualmente exibidos em sessões informais de cinema ou partilhados em canais de internet, atingindo milhares de telespectadores dentro do país, e nas suas diásporas na Europa. Estes filmes e produções audiovisuais constituem recursos valiosos para estudar as percepções populares, relativamente às questões de género. Este artigo revisita a história das políticas de género na Guiné-Bissau para analisar como essa produção vernacular está a representar as transformações de género em reação à instabilidade social e política, um campo que carece de questionamento e pesquisa. Além de identificar padrões comuns nessas narrativas, esta análise procura contextualizá-las, explorando a participação de mulheres e homens no mundo laboral e familiar, propondo uma leitura crítica que considera as omissões dessa produção cinematográfica e audiovisual, elas mesmas, reveladoras.
Conservadorismo, discursos antigênero e disputas narrativas em torno das artes no Brasil
Authors: Parfentieff de Noronha Danielle , Simões Viviani Maria Cristina
Published: June 2023

Nos últimos anos, houve um crescimento importante na propagação de discursos antigênero nos mais distintos campos sociais, com especial atenção aos campos da política, da educação e das artes, constituindo um fenômeno de dimensões globais. No Brasil, tais discursos, que podem ser compreendidos como um dos pilares que sustentam a argumentação do conservadorismo contemporâneo, passaram a protagonizar diversas disputas narrativas em torno das políticas de gênero e de sexualidade. Nesse sentido, este artigo busca investigar o papel dos discursos antigênero na articulação do conservadorismo no Brasil e das disputas narrativas produzidas em torno do tema no sistema das artes. Para isso, sob perspectivas decoloniais e feministas, em diálogo com as ciências sociais, apresentamos na primeira parte do texto uma revisão bibliográfica para, na sequência, articulá-la a eventos artísticos relacionados ao gênero e a pautas LGBTQIAP+ que foram alvo de investidas conservadoras em 2017, véspera de ano eleitoral.
Riesgo de episodio depresivo mayor: prevalencia y algunas variables asociadas en durante la epidemia de la COVID-19
Authors: Caballero-Domínguez Carmen Cecilia , Braga Silveira Luiza María de Olieira , Fuentes-López Carlos Mauricio
Published: June 2023

El riesgo depresivo mayor es un problema de salud pública. Objetivo: Conocer la prevalencia y algunas variables asociadas a riesgo de episodio depresivo mayor (REDM) en adultos colombianos. Materiales y Método: Se realizó un estudio analítico transversal mediante un cuestionario en línea que exploró variables demográficas, REDM (Índice de Bienestar General, WHO-5) y capital social (cinco ítems). Respondieron 700 adultos entre 18 a 76 años (M=37,1; DE=12,7), 32,1% en edades entre 18 y 28 años y 68% fueron mujeres. Resultados: el 24,0% de los participantes puntuaron para bajo capital social y 61,1% se categorizaron como REDM. El género femenino (OR=1,58; IC95% 1,12-2,22), edad joven (18-29 años, OR=3,82; IC95% 2,56-5,72) y bajo capital social (OR=2,05; IC95% 1,37-3,07) se asociaron a REDM. Conclusión: La prevalencia de REDM fue alta y se asoció a género femenino, edad joven (18 a 28 años) y bajo capital social. Es necesario corroborar estos hallazgos en una muestra probabilística de colombianos y cuantificar con más frecuencia el capital social en las investigaciones.