bluuebunny/crossref_metadata_2025 huggingface dataset:
CRISPR/Cas9 Technology as a Modern Genetic Manipulation Tool for Recapitulating of Neurodegenerative Disorders in Large Animal Models
Authors: Barazesh Mahdi , Mohammadi Shiva , Bahrami Yadollah , Mokarram Pooneh , Morowvat Mohammad Hossein , Saidijam Massoud , Karimipoor Morteza , Kavousipour Soudabeh , Vosoughi Amir Reza , Khanaki Korosh
Published: December 2020

Background:

Neurodegenerative diseases are often the consequence of alterations in structures and functions of the Central Nervous System (CNS) in patients. Despite obtaining massive genomic information concerning the molecular basis of these diseases and since the neurological disorders are multifactorial, causal connections between pathological pathways at the molecular level and CNS disorders development have remained obscure and need to be elucidated to a great extent.

Objective:

Animal models serve as accessible and valuable tools for understanding and discovering the roles of causative factors in the development of neurodegenerative disorders and finding appropriate treatments. Contrary to rodents and other small animals, large animals, especially non-human primates (NHPs), are remarkably similar to humans; hence, they establish suitable models for recapitulating the main human’s neuropathological manifestations that may not be seen in rodent models. In addition, they serve as useful models to discover effective therapeutic targets for neurodegenerative disorders due to their similarity to humans in terms of physiology, evolutionary distance, anatomy, and behavior.

Methods:

In this review, we recommend different strategies based on the CRISPR-Cas9 system for generating animal models of human neurodegenerative disorders and explaining in vivo CRISPR-Cas9 delivery procedures that are applied to disease models for therapeutic purposes.

Results:

With the emergence of CRISPR/Cas9 as a modern specific gene-editing technology in the field of genetic engineering, genetic modification procedures such as gene knock-in and knock-out have become increasingly easier compared to traditional gene targeting techniques. Unlike the old techniques, this versatile technology can efficiently generate transgenic large animal models without the need to complicate lab instruments. Hence, these animals can accurately replicate the signs of neurodegenerative disorders.

Conclusion:

Preclinical applications of CRISPR/Cas9 gene-editing technology supply a unique opportunity to establish animal models of neurodegenerative disorders with high accuracy and facilitate perspectives for breakthroughs in the research on the nervous system disease therapy and drug discovery. Furthermore, the useful outcomes of CRISPR applications in various clinical phases are hopeful for their translation to the clinic in a short time.
Natural Chemical Entities as Bioactive Moiety from Weaver Ant, Oecophylla smaragdina: An In Vitro and In-silico Study
Authors: Behera Suchismeeta , Dash Priyanka , Behera Amulyaratna , Behera Chinmaya Chidananda , Mohanty Prafulla Kumar
Published: December 2020

Background:

Since time immemorial, the ethnic community of Mayrubhanj District,
Odisha, India has preferred Olecophylla smaragdina as traditional medicine for their multiple
ailments. Hence, the objective of this investigation is to scientifically examine the myth behind
ethno-zoological claims using chemometric analysis as well as in vitro and in silico study.

Materials and Methods:

The maceration method was used for the extraction of O. smaragdina using
hexane and methanol. In this study, various bioactive compounds of O. smaragdina were identified
through GC-MS analysis followed by an antimicrobial activity. The species were further studied for
their binding modes for in silico inhibition of a choice of bacterial proteins using Biovia Discovery
studio software.

Results:

Tetradecanoic acid, hexadecanoic acid, methyl ester, hexadecenoic acid, n-hexadecanoic
acid, 9-octadecenoic acid, methyl ester, oleic acid and 9-octadecenamide are some important bioactive
constituents identified through GCMS analysis. The hexane extract was found to have maximum
inhibitory activity against Staphyllococus aureus. The inhibitory activity of hexane and methanolic
extract against S. aureus at a concentration of 400 μg/mL was found to be 90% and 83%, respectively.
The high inhibitory capacity of the n-hexane extract was comparable to the standard drug
Gentamycin which further supported the high receptor binding affinity of the identified compound
Octadecanoic acid towards Tyrosol-t RNA synthetase of staphylococcus aureus (PDB ID: 1JIK).

Conclusion:

Interestingly, this is probably the first report that obtained bioactive molecules from
O. smaragdina showing the binding site identification to carry out molecular docking studies, and
better affinity to bind with suitable targeted moiety.
Benzimidazole as Ubiquitous Structural Fragment: An Update on Development of its Green Synthetic Approaches
Authors: Patel Ashish , Shah Drashti , Patel Naiya , Patel Khushbu , Soni Nidhi , Nagani Afzal , Parikh Vruti , Shah Hirak , Bambharoliya Tushar
Published: December 2020

The benzimidazole and its derivatives are privileged heterocyclic motif and important building block for the
development of the biologically active compound. However, several research reports are produced in a short period of time
due to the rapid production of new drugs having a benzimidazole nucleus. In order to understand the current status of the
benzimidazole nucleus in medicinal chemistry science, it is therefore important to combine the latest knowledge with earlier
information. Hence, synthetic organic chemists concentrated on inventing an effective green methodology for
synthesizing benzimidazole derivatives. In addition to this, non-degradable chemical compounds cause the
ecosystem to become fragile, damage or irritation as contaminants and pose a danger to the environment.
However, conventional methods of synthesis need longer heating time, complicated and tedious apparatus set up which
result in high cost and pollution in contrast to greener methods which are inexpensive. In the present review, therefore, we
have attempted to shed light on various synthetic strategies leading to the synthesis of different benzimidazole derivatives
through the direct condensation reaction between o-phenylenediamine and aromatic aldehydes using green chemistry
approaches such as mechanochemistry, ultrasound irradiation, microwave irradiation, environmentally benign
solvents/catalysts, reactant immobilized on a solid support and blue light irradiation.
Impact of Metabolic Surgery on Type-2 Diabetes Remission
Authors: Baiocchi Cejana de Abrantes Figueiredo , Rocha de Sá Diana Aristótelis
Published: December 2020

Diabetes Mellitus is characterized by numerous metabolic disorders, which have in common the serum elevation of glucose, caused for a pancreatic malfunction in insulin secretion and / or its action. It is a non-communicable disease, considered major public health problems and generalized growth worldwide, being a chronic disease, which can generate a high treatment cost. Metabolic surgery is a safe treatment, regulated by the Federal Council of Medicine and useful in treating people with BMI over 30 years of age, who are unable to control pathologies associated with obesity, primarily type 2 diabetes. The general objective of this study is to understand through a literature review the main impacts of metabolic surgery about the remission of DM 2. This present study it is an exploratory and descriptive study carried out through a literature review. Data were collected through research in virtual health databases, at the Virtual Health Library - VHL, Latin American and Caribbean Health Sciences Information System, LILACS, National Library of Medicine - MEDLINE, Scielo, USP database, PUBMED theses and books. Metabolic surgery proof be a good and effective treatment for having and maintaining good weight loss, as well as a significant clinical and metabolic improvement that extends beyond weight loss. Metabolic surgery is a satisfactory way of achieving long-term weight reduction in obese individuals, increasing survival for these patients. Obese patients with DM2 have a long-term remission of DM2 after bariatric / metabolic surgery. Therefore, it concludes that such procedure is effective in the treatment of the disease and other diseases associated with obesity.
Neuroendocrine Response to Psychosocial Stressors, Inflammation Mediators and Brain-periphery Pathways of Adaptation
Authors: Palego Lionella , Giannaccini Gino , Betti Laura
Published: December 2020

Threats, challenging events, adverse experiences, predictable or unpredictable, namely
stressors, characterize life, being unavoidable for humans. The hypothalamus-pituitary-adrenal
axis (HPA) and the sympathetic nervous system (SNS) are well-known to underlie adaptation to
psychosocial stress in the context of other interacting systems, signals and mediators. However,
much more effort is necessary to elucidate these modulatory cues for a better understanding of
how and why the "brain-body axis" acts for resilience or, on the contrary, cannot cope with stress
from a biochemical and biological point of view. Indeed, failure to adapt increases the risk of developing
and/or relapsing mental illnesses such as burnout, post-traumatic stress disorder
(PTSD), and at least some types of depression, even favoring/worsening neurodegenerative and
somatic comorbidities, especially in the elderly.
We will review here the current knowledge on this area, focusing on works presenting the main
brain centers responsible for stressor interpretation and processing, together with those underscoring
the physiology/biochemistry of endogenous stress responses. Autonomic and HPA patterns,
inflammatory cascades and energy/redox metabolic arrays will be presented as allostasis
promoters, leading towards adaptation to psychosocial stress and homeostasis, but also as possible
vulnerability factors for allostatic overload and non-adaptive reactions. Besides, the existence
of allostasis buffering systems will be treated. Finally, we will suggest promising lines of future
research, particularly the use of animal and cell culture models together with human studies by
means of high-throughput multi-omics technologies, which could entangle the biochemical signature
of resilience or stress-related illness, a considerably helpful facet for improving patients’
treatment and monitoring.
Composite Membrane and Evaluation on Separation Oil/Water
Authors: de Oliveira Luana Araújo , Rodrigues Meiry Gláucia Freire , dos Santos Barbosa Antonielly , Cunha Rochélia Silva Souza , Mota Joseane Damasceno
Published: December 2020

Background:

The generation of wastewater contaminated with organic compounds, release or spill into these
water bodies can lead to serious environmental problems. The removal of chemical pollutants in water presents itself as
one of the central issues regarding the issue of environmental remediation. In this sense, membranes, haves gained
increasing importance in the environmental area.

Objective:

This present study aims to develop a composite membrane
using UHMWPE/LDPE/CTAC-HGC to be used for oil/water separation of wastewater effluents.

Methods:

The
polymeric membrane and composite membrane were prepared by uniaxial dry compaction and sintering. Both hard green
clay (HGC) and hard green clay organophilized with cetyl trimethyl ammonium chloride (CTAC-HGC) were
characterized by X-ray Diffraction (XRD), infrared spectroscopy (IR) and scanning electron microscopy (SEM).
UHMWPE, polymeric membrane and composite membrane were characterized by XRD and SEM.

Result:

The water flux
through the composite membrane was evaluated using pure water as a permeate. The potential of the composite membrane
to separate oil-water emulsions was tested.

Conclusions:

The composite membrane showed excellent removal of the oil,
exhibiting removal of more than 99.60 %, evidencing the process of composite membrane separation as an alternative
technology for the treatment of oil.
Wonderen in de Bijbel
Authors: van de Beek A.
Published: December 2020

Miracles in the Bible are not unnatural. Rather, they are singular events or stories about singular events which make people wonder or evoke reactions. Some of these events are historical such as the exodus of Israel from Egypt. Others, such as Gods descent on Mount Sinai remain beyond normal history, or they relate a divine act which initiates history, or put it into a new perspective, such as the narrative about creation and the birth and resurrection of Jesus. These do not represent normal historical discourse. Still others, the parables and Jonah, correct human thoughts and attitudes. When reflecting on miracles in the Bible, therefore, it is important to take into account the literary genre and the character of events which are told. It is not sufficient or often not even possible to answer the question: ‘Did it really happen or not?’ The biblical miracle stories tell us about God and Jesus in whom He manifested himself, both of which are beyond human comprehension and rationality, as is the Resurrection.
Wonderen als tekenen van heiligheid
Authors: Lindeijer S.J. M.
Published: December 2020

Miracles, like the saints, are one of the most wondrous parts of the life of the Church since the earliest times. As ‘the finger of God’ pointing to sanctity (pope Francis), they play a particular role in canonization. The procedures to ascertain miracles, 95% of them healings, have been refined over the past four centuries, particularly in the 20th century, which also saw fundamental developments in the theology of miracles. Since 1983 fewer miracles have been required for a beatification or canonization. Some candidates for sainthood have been raised to the altar on the basis of a single miracle, based on the common intercession of the saints.
Focus. Een blijvend lastig thema: geweld
Authors: Peels H.G.L.
Published: December 2020

N.a.v.  Jacques van Ruiten and Koert van Bekkum (red.), Violence in the Hebrew Bible between Text and Reception [Oudtestamentische Studiën 79] (Leiden/Boston: Brill, 2020), x + 438 p., € 138,00 (ISBN 9789004434677).
A Systematic Review and Meta-Analysis for Better Measurement of Listening Effort in Adults with Hearing Loss
Authors: Kwak Chanbeom , Han Woojae
Published: December 2020

The present study aimed to identify better tools for measuring listening effort in the hearing-impaired and/or hearing aid users and to suggest its clinical implication by using systematic review and meta-analysis. To search articles from six electronic databases, ‘listening effort’, ‘hearing loss/hearing impaired’, and ‘hearing aid(s)’ were used as their key terms. Although 8,761 articles were found initially, only 19 articles which met the inclusion criteria were applied to the further review and analysis. In a checklist of the study quality, there was no significant difference between the articles. Based on meta-analysis of three subgroups (i.e., objective, subjective, and self-report rating), the objective measurements showed statistically significant and the highest effect size (1.031, 95% confidence interval: -0.106-2.169), whereas the self-report rating had the lowest effect size (-1.280, 95% confidence interval: -4.180-1.620) with no significance. Although the funnel plot was asymmetrical, the Egger’s regression asymmetry test revealed no publication bias. In sum, the objective measurement showed the most effective way to evaluate the listening effort for the hearing-impaired and/or hearing aid users. However, there was a non-negligible variance between the types of measurements. In the following study, we suggest to investigate certain relationship between listening effort and speech perception performance in the hearing-impaired and/or hearing aid users and to establish standardized criteria for clinical purposes of the listening effort.
Звуковой удар от тонкого тела и локальных областей нагрева сверхзвукового набегающего потока
Authors: Потапкин А.В. , Москвичев Д.Ю.
Published: December 2020

The problem of a sonic boom generated by a slender body and local regions of supersonic flow heating is solved numerically. The free-stream Mach number of the air flow is 2. The calculations are performed by a combined method of phantom bodies. The results show that local heating of the incoming flow can ensure sonic boom mitigation. The sonic boom level depends on the number of local regions of incoming flow heating. One region of flow heating can reduce the sonic boom by 20% as compared to the sonic boom level in the cold flow. Moreover, consecutive heating of the incoming flow in two regions provides sonic boom reduction by more than 30%.
Влияние вида функции распределения электронов в плазме и дисперсии по энергии электронного пучка на устойчивость низковольтного пучкового разряда
Authors: Сухомлинов В.С. , Матвеев P.М. , Мустафаев А.С. , Павлов В.А. , Гордеев С.В.
Published: December 2020

Within the framework of the kinetic approach, the conditions for the loss of stability of a low-voltage beam discharge in inert gases (LVBD) are studied depending on the temperature of the electron beam, the dispersion of the electron beam velocity in the direction of the discharge axis, and the form of the electron energy distribution function (EEDF). Regimes are considered when the interelectrode distance is on the order of the electron mean free path relative to elastic collisions with inert gas atoms.
It is shown that the beam temperature Tb, determined in the LVBD by the cathode temperature not exceeding 1500 K, and the dispersion of the beam electron energy, which in the LVBD can be significantly higher than kTb and reaches 1 - 2 eV, have little effect on the conditions for the loss of stability of the LVBD and the magnitude of the growth rate of disturbance amplification at frequencies up to plasma
It was found that the form of the EEDF monotonically decreasing with increasing electron energy also does not affect the parameters of the perturbations propagating in the LVBD at the beam energy much higher than the average electron energy in the plasma. The results obtained are applicable not only to LVBD, but also to other types of self-sustained beam discharges.
Формирование двух импульсов тока пучка убегающих электронов
Authors: Белоплотов Д.В. , Тарасенко В.Ф. , Сорокин Д.А. , Шкляев В.А.
Published: December 2020

The conditions for the formation of two current pulses of runaway electron beams during the breakdown of a point-to-plane and tube-to-plane gaps in high-pressure air, nitrogen, and helium are studied. It has been shown experimentally that, depending on a pressure and kind of gas, a rise time of voltage pulse with an amplitude of tens of kilovolts, three modes of generation of runaway electron beams are observed. In the first mode, a single current pulse of runaway electron beam is observed at the maximum voltage across the gap, when a streamer appears in the vicinity of the pointed electrode (cathode). Its duration is ≈100 ps. In the second mode, two current pulses of runaway electron beams are observed at a lower pressure. The first pulse is generated as in the first mode. The second pulse is generated after the gap is bridged by the streamer (the first ionization wave). The electron energy in the second pulse is significantly less than in the first one, but the duration and amplitude of second current pulse under optimal conditions are greater. The third mode is implemented at lower pressures than in the second one. The generation of runaway electrons continues after the first pulse without a pause in the quasi-stationary stage. The total current pulse duration is hundreds of picoseconds.
Расчет остаточных напряжений при коноскопических измерениях в профилированных монокристаллах сапфира
Authors: Бахолдин С.И. , Крымов В.М. , Носов Ю.Г.
Published: December 2020

The article deals with the measurement of residual stresses that are formed in shaped sapphire single crystals when they are grown from a melt. An algorithm is developed for calculating the normal components of the residual stress tensor from the data of optical measurements of residual stresses by the conoscopy method for optically uniaxial crystals in the form of plates. Examples of measuring residual stresses and calculating normal components for a square rod and a basal-faceted sapphire ribbon are given. It is shown that normal stresses are concentrated mainly along the periphery of the plates and reach up to 25 MPa in the rod and 70 MPa in the strip.
Магнитные свойства композита частиц DyMn-=SUB=-2-=/SUB=-O-=SUB=-5-=/SUB=--Mn-=SUB=-3-=/SUB=-O-=SUB=-4-=/SUB=-
Authors: Патрин Г.С. , Матаев М.М. , Абдраймова М.Р. , Турсинова Ж.И. , Кездикбаева А.Т. , Шиян Я.Г. , Плеханов В.Г.
Published: December 2020

The paper presents the results of the experimental studies of magnetic and resonance properties of the DyMn2O5 – Mn3O4 particles composite. There are two magnetic transitions at temperatures T1  65 K and T2  230 K. T1 differs from the transition temperatures for the initial materials, and this fact is associated with the interparticle interaction. T2 corresponds to the impurity phase DyMnO3 (1 at.%). Three peaks of microwave absorption are observed in the magnetic resonance spectrum, which is explained in the framework of the model of a two-phase system in magnetic relation. One resonance is attributed to Mn3O4 and the other two peaks refer to the ensemble of strongly anisotropic DyMn2O5 particles with a random distribution of anisotropy axes.

Patrin Gennady Semionovich1,3
Mataev Mukhametkali Musagalievich2
Abdraimova Moldir Rashidovna2
Tursinova Zhanar Iliyasovna2
Kezdikbaeva Asel Taupykovna4
Shiyan Yaroslav Germanovich1,3
Plekhanov Vasil Granitovich1

1 Siberian Federal University, Svobodny pr. 79, Krasnoyarsk, 660041, Russia
2 Kazakh State Women’s Teacher Training University, Aiteke bi, 99, Almaty, 050000, Kazakhstan
3 L.V. Kirensky Institute of Physics, Federal Research Center KSC, Siberian Branch, Russian Academy of Sciences, Krasnoyarsk, 660036 Russia
4 E.A. Buketov Karaganda State University, st. University 28, City of Karaganda, 100028, Kazakhstan
О влиянии анизотропной проводимости углекомпозитных материалов на параметры рупорной антенны C-диапазона
Authors: Дугин Н.А. , Заборонкова Т.М. , Беляев Г.Р. , Мясников Е.Н.
Published: December 2020

The influence of anisotropic conductivity of composite materials used in the manufacture of antennas on the parameters of antenna-feeder microwave devices has been considered. To test experimentally the possibility of such an effect, horn antennas of the L– and C– frequency bands were created from carbon-composite materials of various structures with a graphene-containing epoxy-binding substance. The study of the polarization characteristics of these antennas showed that the presence of anisotropic conductivity of the walls of the waveguide part of horn antennas made of composite materials leads to a change in the parameters of the antennas, which is more noticeable for high –frequency C-band antennas.
Heart Rate Measurements in Patients with Obstructive Sleep Apnea and Atrial Fibrillation: Prospective Pilot Study Assessing Apple Watch’s Agreement With Telemetry Data
Authors: Huynh Pauline , Shan Rongzi , Osuji Ngozi , Ding Jie , Isakadze Nino , Marvel Francoise A , Sharma Garima , Martin Seth S
Published: December 2020

Background

Patients with obstructive sleep apnea (OSA) are at a higher risk for atrial fibrillation (AF). Consumer wearable heart rate (HR) sensors may be a means for passive HR monitoring in patients with AF.

Objective

The aim of this study was to assess the Apple Watch’s agreement with telemetry in measuring HR in patients with OSA in AF.

Methods

Patients with OSA in AF were prospectively recruited prior to cardioversion/ablation procedures. HR was sampled every 10 seconds for 60 seconds using telemetry and an Apple Watch concomitantly. Agreement of Apple Watch with telemetry, which is the current gold-standard device for measuring HR, was assessed using mixed effects limits agreement and Lin’s concordance correlation coefficient.

Results

A total of 20 patients (mean 66 [SD 6.5] years, 85% [n=17] male) participated in this study, yielding 134 HR observations per device. Modified Bland–Altman plot revealed that the variability of the paired difference of the Apple Watch compared with telemetry increased as the magnitude of HR measurements increased. The Apple Watch produced regression-based 95% limits of agreement of 27.8 – 0.3 × average HR – 15.0 to 27.8 – 0.3 × average HR + 15.0 beats per minute (bpm) with a mean bias of 27.8 – 0.33 × average HR bpm. Lin’s concordance correlation coefficient was 0.88 (95% CI 0.85-0.91), suggesting acceptable agreement between the Apple Watch and telemetry.

Conclusions

In patients with OSA in AF, the Apple Watch provided acceptable agreement with HR measurements by telemetry. Further studies with larger sample populations and wider range of HR are needed to confirm these findings.
Best Practices for Virtual Engagement of Patient-Centered Outcomes Research Teams During and After the COVID-19 Pandemic: Qualitative Study
Authors: Thayer Erin K , Pam Molly , Al Achkar Morhaf , Mentch Laura , Brown Georgia , Kazmerski Traci M , Godfrey Emily
Published: December 2020

Background

Patient-centered outcomes research (PCOR) engages patients as partners in research and focuses on questions and outcomes that are important to patients. The COVID-19 pandemic has forced PCOR teams to engage through web-based platforms rather than in person. Similarly, virtual engagement is the only safe alternative for members of the cystic fibrosis (CF) community, who spend their lives following strict infection control guidelines and are already restricted from in-person interactions. In the absence of universal best practices, the CF community has developed its own guidelines to help PCOR teams engage through web-based platforms.

Objective

This study aimed to identify the important attributes, facilitators, and barriers to teams when selecting web-based platforms.

Methods

We conducted semistructured interviews with CF community members, nonprofit stakeholders, and researchers to obtain information regarding their experience with using web-based platforms, including the effectiveness and efficiency of these platforms and their satisfaction with and confidence while using each platform. Interviews conducted via Zoom were audio recorded and transcribed. We identified key themes through content analysis with an iterative, inductive, and deductive coding process.

Results

In total, 15 participants reported using web-based platforms for meetings, project management, document sharing, scheduling, and communication. When selecting web-based platforms, participants valued their accessibility, ease of use, and integration with other platforms. Participants speculated that successful web-based collaboration involved platforms that emulate in-person interactions, recognized the digital literacy levels of the team members, intentionally aligned platforms with collaboration goals, and achieved team member buy-in to adopt new platforms.

Conclusions

Successful web-based engagement in PCOR requires the use of multiple platforms in order to fully meet the asynchronous or synchronous goals of the project. This study identified the key attributes for the successful practice of PCOR on web-based platforms and the common challenges and solutions associated with their use. Our findings provide the best practices for selecting platforms and the lessons learned through web-based PCOR collaborations.
Development and Evaluation of a Decision Aid to Support Patients’ Participatory Decision-Making for Tumor-Specific and Palliative Therapy for Advanced Cancer: Protocol for a Pre-Post Study (Preprint)
Authors: Laryionava Katsiaryna , Schildmann Jan , Wensing Michael , Wedding Ullrich , Surmann Bastian , Woydack Lena , Krug Katja , Winkler Eva
Published: December 2020

BACKGROUND

To support advanced cancer patients and their oncologists in therapeutic decisions, we aim to develop a decision aid (DA) in a multiphased, bicentric study. The DA aims to help patients to better understand risks and benefits of the available treatment options including the options of standard palliative care or cancer-specific treatment (ie, off-label drug use within an individual treatment plan).

OBJECTIVE

This study protocol outlines the development and testing of the DA in a pre-post study targeting a heterogeneous population of advanced cancer patients.

METHODS

In the first step, we will assess patients’ information and decisional needs as well as the views of the health care providers regarding the content and implementation of the DA. Through a scoping review, we aim to analyze specific characteristics of the decision-making process and to specify the treatment options, outcomes, and probabilities. An interdisciplinary research group of experts will develop and review the DA. In the second step, testing of the DA (design and field testing) with patients and oncologists will be conducted. As a last step, we will run a pre-post design study with 70 doctor-patient encounters to assess improvements on the primary study outcome: patients’ level of decisional conflict. In addition, the user acceptance of all involved parties will be tested.

RESULTS

Interviews with cancer patients, oncologists, and health care providers (ie, nurses, nutritionists) as well as a literature review from phase I have been completed. The field testing is scheduled for April 2021 to August 2021, with the final revision scheduled for September 2021. The pre-post study of the DA and acceptance testing are scheduled to start in October 2021 and shall be finished in September 2022.

CONCLUSIONS

A unique feature of this study is the development of a DA for patients with different types of advanced cancer, which covers a wide range of topics relevant for patients near the end of life such as forgoing cancer-specific therapy and switching to best supportive care.

CLINICALTRIAL

ClinicalTrials.gov NCT04606238; https://clinicaltrials.gov/ct2/show/NCT04606238.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/24954
A Dynamic Programming Approach for Secure and Accurate Content-Based Retrieval of Medical Images (Preprint)
Authors: Sun Jinhong , Qi Liang , Song Yinglei , Qu Junfeng , Khosravi Mohammad
Published: December 2020

UNSTRUCTURED

Recently, with the explosive growth in the number of available medical images generated by medical imaging systems, content-based retrieval of medical images has become an important method for the diagnosis and study of many diseases. Most existing methods find medical images similar to a given one based on the extraction and comparison of crucial image features. However, similarity values computed with low level visual features of an image generally do not match the similarity obtained from human observation well. The overall performance of these methods is thus often unsatisfactory. This paper proposes a dynamic programming approach for content-based retrieval of medical images. The approach represents an image with three different histograms that contain both crucial intensity and textural features of the image. The similarity between two images is evaluated with a dynamic programming approach that can optimally align the peaks in the corresponding histograms from both images. Experiments show that the proposed approach is able to generate retrieval results with high accuracy. A comparison with state-of-the-art approaches for content-based medical image retrieval shows that the proposed approach can achieve higher retrieval accuracy in the testing dataset. As a result, higher retrieval accuracy may lead to more reliable results for the diagnosis and treatment of many diseases. The proposed approach is thus potentially useful for improving the security of many applications in health informatics.
MERAYAKAN RECORDS IN CONTEXTS: LATAR DAN KANDUNGAN STANDAR DESKRIPSI ARSIP TERBARU KELUARAN INTERNATIONAL COUNCIL ON ARCHIVES
Authors: Pratama Raistiwar
Published: December 2020

This article aims to describe several major themes of a newly released standard by International Committee on Archives, namely Records in Contexts (RiC). More than mere comprising all four existing standards, RiC to uplift function and activity of records within their own origin contexts. Almost three decades after the publication of the first standard (General International Standard Archival Description [ISAD-G]), RiC has developed its own understanding about major archival themes such as provenance, fonds, and original order, to comply with a very recent development of rapidly changing medium by questioning the famous adagium “medium is the message” back in 1970’s and reading machines that are understood as being separated from the records itselves. Either records or archives have shifted from texts to contexts.
Pembuatan Peta Foto Udara Kelurahan Wates
Authors: Farida Annisa
Published: December 2020

ABSTRAK Kelurahan Wates merupakan sebuah kelurahan yang berada di Kecamatan Wates, Kabupaten Kulon Progo. Pada awal bedirinya Kelurahan Wates ini berbentuk desa, dimana seluruh asset menjadi milik desa dan digunakan seluasnya untuk kemakmuran dan kesejahteraan warga Desa Wates. Pada tanggal 1 Desember 2010 status Desa Wates berubah menjadi Kelurahan Wates. Kelurahan Wates merupakan pusat pemerintahan Kabupaten Kulon Progo, sehingga secara tidak langsung aktivitas kelurahan berpengaruh terhadap kelangsungan Pemerintahan Kabupaten Kulon Progo karena terbatasnya anggaran, beberapa aspek dasar dalam hal data geospasial juga tidak muncul di dalam Renja 2017. Sebagai contoh belum adanya rencana kegiatan dalam hal pemetaan desa/kelurahan. Sehingga hal ini bisa menjadi peluang bagi perguruan tinggi untuk melaksanakan kegiatan penelitian dan pengabdian kepada masyarakat, khususnya dalam penyediaan data geospasial. Dari pemaparan permasalahan di atas, dimana yang menjadi pokok permasalahan adalah ketiadaan data geospasial, maka dapat diberikan solusi dengan pengadaan salah satu bentuk data geospasial, yaitu Peta Foto Udara Kelurahan Wates skala besar, yaitu antara 1:1000 – 1:5000. luaran dari pengabdian ini, yaitu berupa Peta Foto Udara Kelurahan Wates skala besar. Dari peta foto yang akan dihasilkan ini, nantinya dapat dikembangkan untuk membuat peta-peta turunan lainnya, seperti peta sarana-prasarana, peta jaringan jalan, dan sistem informasi desa yang direncanakan akan dibuat dalam pengabdian masyarakat pada tahun-tahun berikutnya. Kata Kunci: peta foto, foto udara, Wates, geospasial ABSTRACT Kelurahan Wates located in Wates District, Kulon Progo Regency. In the beginning, the Kelurahan Wates Wates was in the form of a village, where all assets belonged to the village and the company to the Wates community and village. On December 1st, 2010, the status of Wates Village changed to Kelurahan Wates. Wates Subdistrict is the center of Kulon Progo Regency government, indirectly for the kelurahan that is related to Kulon Progo Regency Government due to limited budgets, some things in the geospatial data will not appear in Renja 2017. For example, there are no planned activities regarding village / kelurahan mapping. Thus, this can be an opportunity for universities to carry out research and community service activities, especially in the availability of geospatial data. From the presentation of the problem, the main thing is the absence of geospatial data, and it can be provided with one form of geospatial data, namely the large-scale Wates Urban Air Photo Map, which is between 1: 1000-1: 5000. The output from this service, in the form of Large-scale Wates Urban Air Photo Map. From the maps that will be produced, it can be developed to make other derivative maps, such as facilities and infrastructure maps, road network maps, and village information systems that will be created in community service in the following years.. Keywords: aerial map, aerial photograph, Wates, Geospatial
APLIKASI TEKNOLOGI FINISHING KAYU BAGI KELOMPOK PERTUKANGAN DESA PAGERHARJO, KECAMATAN SAMIGALUH KABUPATEN KULON PROGO, D.I. YOGYAKARTA
Authors: Ngadianto Agus , Oktalina Silvi Nur , Prasetyo Eko , Wibowo Agung Budhi
Published: December 2020

Kelompok pertukangan Muda Taruna Makmur dan Mitra Mandiri merupakan kelompok usaha mikro dibidang produk perkayuan dan mebel yang berlokasi di Desa Pagerharjo Kecamatan Samigaluh, Kabupaten Kulon Progo, D.I. Yogyakarta. Kelompok pertukangan ini beranggotakan pemuda-pemuda dalam satu desa. Mengingat potensi kayu dari hutan rakyat di Desa Pagerharjo yang sangat besar, maka sangat potensial sekali untuk dibuat usaha pembuatan produk mebel serta kerajinan. Permasalahan yang dialami oleh kelompok mitra adalah rendahnya kemampuan dalam membuat produk perkayuan sampai tahap finishing, kurangnya pemanfaatan teknologi informasi sebagai sarana pemasaran, minimnya kemampuan dalam membuat inovasi dan desain produk serta kurangnya keahlian dalam teknologi finishing kayu. Selama ini, produk perkayuan yang dihasilkan adalah berupa produk mebel setengah jadi seperti meja, kursi dan lemari yang dijual ke industri mebel kayu yang lebih besar atau dijual ke konsumen secara langsung. Tujuan program ini adalah untuk meningkatkan kapasitas kelompok pertukangan di Desa Pagerharjo dalam teknologi finishing kayu, manajemen pemasaran serta membuat inovasi desain produk. Solusi yang ditawarkan dalam program ini meliputi: pelatihan teknologi finishing produk perkayuan atau mebel, peningkatan kemampuan dalam desain dan inovasi produk  serta pelatihan penggunaan teknologi informasi sebagai sarana pemasaran. Kata kunci: Kelompok pertukangan, mebel, produk kayu, teknologi informasi, teknologi finishing
PENYULINGAN MINYAK KENANGA DAN PRODUK TURUNANNYA DI DESA JINGAH HABANG ILIR, KECAMATAN KARANG INTAN, KABUPATEN BANJAR, KALIMANTAN SELATAN
Authors: Istikowati Wiwin Tyas
Published: December 2020

Desa Jingah Habang Ilir memiliki potensi besar sebagai desa penghasil bunga-bungaan (melati, kenanga, dan mawar). Permasalahan yang dihadapi oleh masyarakat pada usaha budidaya bunga ini adalah harga jualnya tidak stabil, masa jual bunga yang pendek karena bunga harus dalam kondisi segar ketika dipasarkan, dan kemampuan penguasaan teknologi mereka masih relatif rendah untuk menciptakan produk-produk lain yang bisa diperoleh dari bunga.  Dengan kegiatan Ipteks bagi Masyarakat yang berjudul IbM Penyulingan Minyak Atsiri (Kenanga) di Desa Jingah Habang Ilir, pelaksana kegiatan bertujuan memberikan solusi dari permasalahan yang dihadapi oleh masyarakat. Bunga kenanga yang pada awalnya dijual dalam kondisi segar dengan harga rata-rata Rp.15.000,00 per 1000,00 tangkai bunga diolah menjadi produk turunannya yaitu minyak atsiri yang berpotensi untuk dibuat sebagai bahan parfum, hand and body lotion, lulur mandi, aroma terapi dan cream message. Pembuatan produk-produk turunan dari bunga kenanga ini dapat meningkatkan nilai jual dan masa simpannya. Selain itu dengan adanya pelatihan penyulingan minyak atsiri (Kenanga) dan aneka produk turunannya pada masyarakat Desa Jingah Habang Ilir mengubah pandangan mereka bahwa bunga merupakan komoditi yang bisa dikembangkan menjadi berbagai produk yang laku di pasaran. Kegiatan pelatihan penyulingan minyak atsiri (kenanga) di Desa Jingah Habang Ilir ini berjalan dengan baik dan lancar. Masyarakat sangat antusias dalam mengikuti kegiatan ini. Mereka aktif melakukan pembuatan berbagai produk yang diajarkan dan mempraktikkannya sendiri setelah kegiatan berlangsung.
Optimalisasi Kegiatan Posyandu dengan Pelatihan Kader melalui Program Kuliah Kerja Nyata Mahasiswa (KKNM)
Authors: Susanti Ari Indra , Rinawan Fedri Ruluwedrata
Published: December 2020

The KKN program is an effort to develop student creativity in helping and jumping directly to the problems that exist in society. That problem, including the lack optimal functioning of posyandu, such as recording and reporting of data that is still manual, lack of funds, and lack of cadre knowledge in Giving Additional Foods (PMT) varies. The community service activities are part of KKN activities many of 12 people  consisting of the Faculty of Government and Social Sciences, MIPA Faculty, Food Engineering Faculty, and Psychology Faculty. This activity was held in October until November 2018 in Pasawahan village. This activity is in the form of various training for cadres, such as training for the use of the iposyandu application for recording and reporting data during posyandu activities, training on Additional Food Making (PMT) to be given to toddlers who come to Posyandu as well as business fund training and sponsorship. Cadres were given a pretest and posttest before and after the training was given. With the implementation of various trainings, cadre knowledge and skills are improving in managing and implementing posyandu activities.
Destinasi Wisata Pintar untuk Meningkatkan Pengalaman Wisata Melalui Personalisasi Layanan (Studi Kasus Pada Perusahaan Pariwisata di Jawa Tengah)
Authors: Guritno Bambang , Listyorini Haniek , Aprilliani Renny , Sutomo Y
Published: December 2020

Smart concepts into tourism destinations are dynamically embraced to connect stakeholders through technology platforms where information related to tourism activities can be exchanged directly. Instant information exchange has also created a huge data collection known as Big Data which may be computationally analyzed to reveal patterns and trends. Smart Tourism Destinations must make optimum use of Big Data by offering services that are suitable for the preferences of the user at the right time. In this connection, this paper aims to understand the contribution of how smart Tourism Destinations can potentially enhance the tourism experience through offering more personalized products or services to meet each visitor's unique needs and preferences. By using the skinative method and descriptive approach and the sample was taken through purposive sampling, the companies engaged in the tourism sector obtained the following research results: Understanding the needs, desires and desires of travelers became increasingly important for the competitiveness of tourism destinations. Therefore, the findings in this study are expected to be very beneficial for the number of tourism destinations.
PEMBINAAN HIGIENE PERSONAL PADA PENJAMAH MAKANAN MENGGUNAKAN MEDIA CELEMEK DI KANTIN UNIVERSITAS ESA UNGGUL
Authors: Swamilaksita Prita Dhyani
Published: December 2020

Keberhasilan penyelenggaran makanan dilihat dari higiene perorangan penjamah makanan. Penjamah makanan di perlukan dalam proses penyelenggaran makanan, yang secara langsung berhubungan dengan makanan dan peralatan mulai dari tahap persiapan, pembersihan, pengolahan, pengangkutan sampai penyajian. Penjamah makanan yang tidak memperhatikan higiene perorangan dalam pengolahan makanan dapat menimbulkan kontaminasi bakteri  pada makanan. Menurut peraturan menteri kesehatan republik Indonesia nomor 1096/menkes/per/VI/2011 untuk mencegah penularan penyakit dan kontaminasi terhadap makanan yaitu antara lain tidak mengunyah, tidak merokok dan  menggunakan alat pelindung diri seperti celemek, tutup kepala, sarung tangan,  sepatu kedap air. Makanan yang tidak dikelola dengan baik dan benar oleh penjamah makanan dapat menimbulkan penyakit. Kegiatan abdimas ini dilakukan untuk membina personal higiene di kantin universitas esa unggul dengan harapan selain peningkatan pengetahuan, perilaku pengggunaan APD pada penjamah makanan dapat diterapkan sehingga penyediaan makanan di kantin Universitas Esa Unggul dapat terjamin kemanannya. Metode yang digunakan dalam kegiatan sosialisasi adalah metode ceramah menggunakan media celemek. Sasaran pada kegiatan ini seluruh penjamah makanan yang menjual makanannya di kantin Universitas Esa Unggul yang pada saat pelaksanaan berjumlah 10 orang. Hasil kegiatan meninjukan bahwa media celemek ini cukup efektif dalam meningkatkan pengetahuan dan merubah perilaku penjamah makanan. Sehingga perlu dilaksanakan kegiatan ini secara rutin dan konsisten untuk menjaga kepatuhan dalam pengaplikasian personal higiene dalam penyediaan makanan.
OPTIMALISASI WEBSITE KEDIRIMENJUAL.COM UNTUK MENINGKATKAN BRAND AWARENESS PRODUK UMKM KABUPATEN KEDIRI MELALUI DIGITAL MARKETING
Authors: Wahyudi Setyo Tri , Laksono Sonny Subroto M , Rosalin Sovia , Natalia Deasy Chrisnia , Septian M. Daniel
Published: December 2020

Digital marketing menjadi kunci untuk mengembangkan dan mengenalkan produk daerah di kancah global. Pemerintah Daerah Kediri memfasilitasi pelaku UMKM dalam pemasaran produk melalui website kedirimenjual.com yang dikelola Dinas Perdagangan Kabupaten Kediri. Melalui Kegiatan Program Doktor Mengabdi (DM Mengabdi) yang digagas oleh LPPM Universitas Brawijaya, berusaha membantu dalam upaya mengoptimalkan website tersebut. Berdasarkan identifikasi permasalahan, terdapat beberapa aspek yang perlu dibenahi untuk optimalisasi website meliputi spesifikasi website, sumberdaya manusia pengelola website, dan UMKM yang akan memasarkan produknya.Desain kegiatan dilakukan melalui tahapan analisis komparasi website kedirimenjual.com dengan kompetitor sejenis, analisis kebutuhan content/muatan website Kedirimenjual.com, merancang dan membangun sistem aplikasi website Kedirimenjual.com, uji coba website kedirimenjual.com, dan pemeliharaan website dengan update content dan informasi produk UMKM di Kabupaten Kediri. Optimalisasi spesifikasi website telah dilakukan dengan melakukan desain ulang website sebelumnya, sehingga lebih dinamis dan interaktif dengan beberapa fitur tambahan. Sedangkan peningkatan kemampuan pengelola website juga telah dilakukan dengan pelaksanaan Training of Trainers bagi pengelola Admin di Dinas Perdagangan. Berdasarkan evaluasi dan monitoring oleh Pemerintah Daerah Kabupaten Kediri, kegiatan optimalisasi website Kedirimenjual.com telah memberikan dampak signifikan bagi pengembangan dan promosi UMKM di wilayah Kabupaten Kediri dan luar daerah. Namun demikian, menjaga keberlanjutan bagi pelaku UMKM dalam berproduksi serta memasarkan melalui platform website masih menjadi tantangan bagi Dinas Perdagangan Kabupaten Kediri. Oleh karena itu, diperlukan strategi yang terukur untuk menjaga keberlanjutan website tersebut.
The lithic assemblage from Lapa da Galinha (Alcanena, Portuguese Estremadura) and the “Cave Megalithism” phenomenon in the 4th and 3rd millennium BCE
Authors: Van Calker Daniel
Published: December 2020

The present work proposes to present the analysis results of the flaked stone artefacts from Lapa da Galinha, a cave necropolis, located in the Estremadura Limestone Massif, that is a classic example of the funerary practices of the 4th and 3rd millennium BCE. The excavation dates back to 1908, and it was performed by members of the current National Museum of Archaeology, resulting in an extensive votive ensemble, associated with a minimum number of 70 burials. The evident collective nature of the burials, the votive ensemble and the rituals there identified emphasise its “Cave Megalithism” character, an expression that invokes only one of the many facets of the complex phenomenon that is Megalithism. Since the Megalithic funerary structures, such as natural caves, are utilized over a long period of time, it’s not easy- but not impossible- to reclaim in full, the events that took place. Focusing on the flaked stone artefacts, the main goal of this text is to contribute to the reconstruction of the belief system that characterizes the Neolithic and Chalcolithic communities from this region. Hence, the morpho-technological criteria, that followed previously established standards, and raw material analysis of the artefactual categories, even on a macroscopic level, were absolutely essential for us to suggest an extensive diachrony of the funerary use of the natural cave With that in mind, we reflected on the importance of the transformations that occur within the material culture exposed throughout the text and their chronological meaning, but also on the true potential of this artefactual category as a tool to build a solid perspective regarding the symbolism inherent to these funeral practices.