bluuebunny/crossref_metadata_2025 huggingface dataset:
Budd-Chiari Syndrome – A review of the diagnosis and management
Authors:   Liver Unit, Transplant Department, St James University Hospital, Leeds Teaching Hospital’s NHS Trust, Fox MA , Fox JA ,   Geriatric Medicine, Department of Medicine, Royal Bolton Hospital NHS Foundation Trust, Davies MH ,   Liver Unit, Transplant Department, St James University Hospital, Leeds Teaching Hospital’s NHS Trust
Published: June 2021

Budd-Chiari syndrome (BCS) is the liver disease resulting from hepatic venous outflow obstruction comprising a triad of abdominal discomfort, hepatomegaly and ascites. Advances in the management of this disorder over the last three decades have dramatically improved survival. We present a review of the management of BCS followed by a case which illustrates some key points in the diagnosis and treatment of this condition.
What errors can be identified by Pharmacy led medicines reconciliation? A prospective study
Authors:   Pharmacy Department, Mid Essex Hospitals NHS Trust, Richards Marie , Ashiru-Oredope Diane ,   Mid Essex Hospitals NHS Trust, Broomfield, Essex, Chee Nigel ,   Mid Essex Hospitals NHS Trust, Broomfield, Essex,
Published: June 2021

Aim: To establish the nature and frequency of discrepancies identified by pharmacy staff during medicines reconciliation.(MR) Methods: Pharmacy staff collected data prospectively from 161 patients over a 1 week period, including information on any prescription errors identified. Results: In total, 62 patients (48%) taking one or more medications prior to admission to hospital had one or more discrepancies found by pharmacy staff during MR. The most common discrepancy was omission of one or more drugs. Conclusions: Pharmacy staff identified several unintentional discrepancies in prescribing of medications at admission to hospital. Doctors should ensure that intentional changes to patient prescriptions are clearly documented.
Making Sense of Acute Medicine: a guide to diagnosis
Authors:   Department of Respitatory Medicine, University Hospital Lewisham, Lewisham High Street, Lewisham, SE13 6LH. London., Land David , Butler Clare ,   Emergency Medicine Queen Alexandra Hospital Cosham, Portsmouth
Published: June 2021

Making Sense of Acute Medicine: a guide to diagnosis details a symptomatic approach to acute medicine. It begins with a preface that states that many junior doctors seem to employ a ‘scattergun approach to diagnosis’, and often ‘multiple tests’ are requested when a more thoughtful p r o b l e m – b a s e d approach might be better employed. The authors, both Professors of Medicine, are clearly experienced physicians with a wealth of clinical and teaching expertise.
Picture Quiz: A Red Man on the AMU – Answers
Authors:   25 Bernard Ireland House, Royal United Hospital, Bath, BA1 3NG, Kamour Ashraf , Thompson Andrew ,   Musgrove Park Hospital, Parkfield Drive, Taunton, Somerset.
Published: June 2021

Erythroderma (or ‘red man syndrome’) is a diffuse inf lammation of the skin, affecting at least 90% of the skin surface. It can be the clinical manifestation of a variety of dermatological, systemic, malignant and haematological diseases. It can be also the result of a hypersensitivity reaction to drugs.
Isolated Syncope – an Uncommon Presenting Feature of Pulmonary Embolism
Authors:   General Internal Medicine (Oxford Deanery) and Intensive Care Medicine (London Deanery), Chakraborty Arup , Jutley G ,   Acute Medicine (West Midlands Deanery)
Published: June 2021

We describe a case of a 62 year old man who presented with transient loss of consciousness following exertion. On presentation to hospital, he was haemodynamically stable and was not breathless, tachycardic or hypoxic at rest. The finding of exercise-induced desaturation on pulse oximetry triggered further investigations which confirmed the presence of PE.
Quality Improvement and Acute Medicine
Authors:   Respiratory Medicine, Hope Hospital, Salford, Sullivan P
Published: June 2021

The quality of care in AMU has a significant and disproportionate impact on hospital outcomes. Early expert involvement reduces mortality and reduces the risk of hospital associated harm by shortening length of stay.1,2 Sensitive communication during the frightening initial phase of hospital admission can enhance patient and family experience and reduce anxiety.3,4 The inception and development of Acute Medicine as a specialty has done a great deal to improve the early hours of hospital care, but there is still room for improvement. The professionals who work in AMUs are good at delivering excellent care to the patient in front of them, but an extra step is needed to ensure reliable performance, with every patient getting every item of care that they need, whatever the time, day or night. It can be frustrating and difficult to make the changes needed to achieve this and it requires skills that do not ‘come as standard’ in the current medical or nursing curriculum.
Viewpoint: Management of the patient with an ‘incidentally’ raised troponin
Authors:   Frenchay Hospital, North Bristol NHS Trust, Frenchay Park Road, Bristol, BS16 1LE, Ho John
Published: June 2021

Troponin assays are a valuable tool in early risk stratification of patients with ischaemic sounding chest pain. However, troponin is often measured outside of this clinical context. The finding of a raised troponin value may be misinterpreted as an acute coronary syndrome leading to unnecessary and sometimes dangerous anticoagulation. This article looks at some of the considerations which need to be made when interpreting the significance of a raised troponin value.
An ‘Acute’ Presentation of Motor Neuron Disease
Authors:   London Deanery Whittington Hospital NHS Trust, Magdala Avenue, London, N19 5NF, Lad Tanuj S
Published: June 2021

Abstract Motor neurone disease (MND) is a chronic condition which presents mainly in the seventh and eighth decades. It classically presents with a mixture of upper and lower motor neurone features, with a predilection for the limb muscles as the presenting feature. The case report outlined below describes acute respiratory failure requiring non invasive ventilation (NIV), at the time of diagnosis of MND. It highlights the need for the acute physician to be vigilant in the differing forms of presentation of this condition and its subsequent diagnosis and management.
Balloon Tamponade for Variceal Haemorrhage: A Practical Approach
Authors:   St James University Hospital, Leeds Teaching Hospital’s NHS Trust, Fox MA , Fox JA ,   Royal Bolton Hospital NHS Foundation Trust, Stern N ,   University Hospital Aintree, Liverpool, L9 7AL
Published: June 2021

Abstract Balloon tamponade with compression tubes is used to stabilise life-threatening variceal bleeds when first-line endotherapy has failed and acts as a bridge to early definitive therapy. We present an overview of the use of compression tubes for variceal haemorrhage with a focus on insertion technique and aftercare.
Lumbar Puncture
Authors:   Derby Hospitals NHS Foundation Trust, Division of Medical Sciences and Graduate Entry Medicine, University of Nottingham, UK, Cooper Nicola
Published: June 2021

Most junior doctors learn common practical procedures, like lumbar puncture, on the job. This usually involves unstructured observation, demonstration and then supervised practice. Thus, most doctors have learned to perform a lumbar puncture without studying the theory of the procedure in any detail. The result is that patients experience less than optimal care, and more complications than necessary. This article first outlines some educational principles with regard to teaching and learning practical procedures and then describes the theory of diagnostic lumbar puncture.
Picture Quiz: A young patient with a severe headache
Authors:   Salisbury District Hospital, Joshi Vijay , Walters David ,   Salisbury District Hospital
Published: June 2021

A 38 year old woman presented with one day history of acute onset frontal headache which progressively generalised over a few hours. The headache was dull in nature and did not respond to analgesics. A day prior to the onset of headache her family members and the patient had noticed a distinct change in the appearance of her eyes. The headache was not associated with symptoms of meningism, vomiting, seizures, syncope or loss of consciousness. She did not report any weakness in her extremities. There was no recent history of neck trauma or neck pain and no other systemic symptoms.
https://staging.acutemedjournal.co.uk/a-hot-bath-to-calm-what-ails-you-the-cannabis-hyperemesis-syndrome/
Authors:   Glan Clywd Hospital, Rhyl, Denbighshire, LL18 5UJ, UK, Jepson Jacqueline , Whitley Stella ,   Glyndwr University, Mold Road, Wrexham, LL11 2AW, UK, Subbe Christian P ,   Bangor University & Ysbyty Gwynedd Hospital Bangor, Wales, Grundy Lynne ,   Cadwaladr University Health Board
Published: June 2021

Our aim was to identify the perceived educational needs of nurses working in acute medicine to enable development of a training curriculum specifically for this staff group. Methods: Post-graduate nurses from North Wales were invited to list 20 conditions and 10 skills for which they felt under prepared for their work in acute medicine. A workshop was then organized, attended by acute medicine nurses,medical colleagues and educationalists from two local universities to discuss initial data. Results: Nurses identified particular needs for education around presenting symptoms with perceived deficits in knowledge or training. We found a heavy emphasis on respiratory and cardiac conditions. There was considerable overlap with frequent diagnostic categories from non-surgical hospital discharges and with priorities for training of junior doctors. Skills were often those traditionally associated with medical staff or care of patients with critical illnesses. Conclusion: The 20:10 project represents the first attempt to map educational needs of nursing staff on the Acute Medical Units of a large University Health Board using self-reported needs. The identified needs will support professional development, create incentives for recruitment and guide University postgraduate developments and commissioning.
The patient presenting with acute hemiparesis
Authors:   Warrington Hospital NHS Foundation Trust Warrington, UK, Mahawish Karim , Otaiku Olayiwola ,   Warrington Hospital NHS Foundation Trust Warrington, UK
Published: June 2021

Acute hemiparesis is a common cause of presentation to hospital. In the majority of cases the cause is acute stroke, which is ischaemic in 80% of cases. This article aims to provide the reader with a practical approach to the initial management of suspected stroke.The problem-based format highlights some of the specific questions raised in the 2009 curriculum for training in Acute Internal Medicine, with reference to recent guidance from the National Institute for Health and Clinical Excellence (NICE).
Actinomycosis masquerading as malignancy
Authors:   MED Directorate, St James’s Hospital, Dublin, Ireland, O’Riordan Deirdre , Zermansky Adam ,   Neurology, Salford Royal Hospital, Stott Lane, Salford, Manchester, Bishop Paul ,   Histopathology, University Hospital of South Manchester, Southmoor Road, Wythenshawe, Manchester, UK, C.O. Taggart Simon ,   Respiratory Physiology, Salford Royal Hospital, Stott Lane, Salford, Manchester
Published: June 2021

We describe a patient who presented with neurological symptoms and radiological findings consistent with metastatic malignancy in several sites. However, no obvious primary site of tumour was identified and the patient later went on to develop clinical features of sepsis whilst using palliative dexamethasone therapy. A diagnosis of actinomycosis was eventually made on open lung biopsy and the patient recovered completely on penicillin V. This case serves to illustrate the need to obtain a formal tissue diagnosis whenever possible in all cases of suspected malignancy, in addition to exposing the weaknesses inherent in empiric diagnoses.
Trainee Update
Authors:   Society for Acute Medicine, Freeman Kirk , Daniel Amy ,   Society for Acute Medicine, Miller Alice ,   Society for Acute Medicine
Published: June 2021

It was great to see so many of you at SAM Dublin at the beginning of May. For those of you who could not make it to the conference, we thought it would be helpful to summarise some of the best bits within this newsletter. We have concentrated on areas we felt were most relevant to you and your training.
The Acute Physicians Unit in Scarborough Hospital
Authors:   Acute Medicine in Yorkshire Deanery and Honorary Lecturer at Hull York Medical School, Khadjooi Kayvan , Dimopoulos Christos ,   Acute Medicine at Scarborough Hospital, Paterson John ,   Division of Medicine at Scarborough Hospital and Consultant Physician with special interest in Stroke Medicine
Published: June 2021

Aim: The aim of Acute Physicians Unit (APU) in Scarborough Hospital is consultant led delivery of acute medical care. It operates weekdays from 9am to 5pm, staffed by a consultant physician, a trained nurse and an auxiliary nurse. We reviewed the APU activity over 38 months. Results: 7170 patients were referred to APU, mainly from GPs (59.6%) and A&E (26.5%). The most common type of referrals: cardiovascular 21%, neurological 16.9% and respiratory 15.1%. It prevented admission in 2217 cases (30.9%): 22.4% were sent home after assessment in APU and in 8.5% telephone advice was sufficient. Conclusion: The APU has led to early consultant review in 53% of admissions, discharge of 31% of patients and is a useful source of consultation for GPs.
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Authors:   University of Something, Toma Paul
Published: June 2021

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APPLICATION OF FIELD THEORY APPARATUS FOR DESCRIPTION OF AIR MOVEMENT IN MATHEMATICAL MODEL OF PREVENTION OF EMERGENCY SITUATIONS OF TECHNOGENIC CHARACTERISTIC CHARACTER
Authors: Kerchief Ivan
Published: June 2021

Ivan Kerchief, Oleg Mirochnik, Larysa Pereverzieva
APPLICATION OF FIELD THEORY APPARATUS FOR DESCRIPTION OF AIR MOVEMENT IN MATHEMATICAL MODEL OF PREVENTION OF EMERGENCY SITUATIONS OF TECHNOGENIC CHARACTERISTIC CHARACTER

The main provisions of the field theory for the description of air movement processes in the closed premises of administrative buildings in the conditions of emergence of an emergency situation of technogenic character are defined in the work. Based on which the main assumptions are made regarding the problem of mathematical description of the process of air injection into the local volume using a filter ventilation unit in the interests of protecting people from the damaging factors of radioactive and chemical contamination in enclosed office buildings in a man-made emergency. A detailed analysis of the existing regulatory and methodological framework on the issues under consideration allowed us to state the following - known means of protection against radioactive and chemical contamination of the atmosphere are implemented in special protective structures, which are in large numbers in Ukraine, but for objective reasons (obsolete physically and morally) can not be used for its intended purpose. Existing methods of building temporary shelters cannot be implemented due to the rapid development of emergencies at present. Therefore, it is necessary to develop and propose new designs of special rooms in office buildings in the interests of protection and rescue of people from the harmful factors of hazardous substances sprayed into the atmosphere as a result of man-made disasters, which in turn should be based on modern methodological apparatus. closed premises of administrative buildings in the conditions of emergence of an emergency of technogenic character. Given the above, the properties of the vector function used to describe magnetic and other physical fields that do not contradict the provisions of gas dynamics and can be used to describe the problems of air injection in the local volume were considered. It is noted that the direction and modulus of the vector determine the direction and velocity of the air flow through the elementary site. In addition, the vector function allows you to represent (conditionally divide) the air flow as elements of lines or elements of surfaces. Thus, the properties of the vector function allow to use it to describe the processes of air injection into the local volume in the mathematical model of protection of people from the damaging factors of radioactive and chemical pollution in temporary shelters in office buildings in order to protect the population from the damaging factors of radioactive and chemical pollution. arising from man-made accidents and catastrophes.
Key words: emergency situation, field theory, administrative buildings.
La cultural y el arte en el sistema educativo nicaragüense
Authors: Medrano Martínez Anna Danilovna
Published: June 2021

El presente artículo describe la fundamentación y desarrollo de la educación artística en Nicaragua, tomando como punto clave el carácter creativo y dinámico de los autores que han propiciado la importancia de la concepción e identidad cultural de esta nación. De igual manera se describen las razones que permitieron la incorporación de la educación artística en los currículos escolares, desde las ideologías políticas y sociales hasta las necesidades propias de la cultura artística de los nicaragüenses. Otro aspecto relevante es la articulación de los subsistemas educativos en función de la mejora educativa en la formación de una sociedad innovadora y promotora de su identidad cultural.
Improving Wellington region’s resilience through integrated infrastructure resilience investments
Authors: Sadashiva Vinod , Mowll Richard , Uma S R , Lin Sheng L , Heron David , Horspool Nick , Nayyerloo Mostafa , Williams James , Syed Yasir , Buxton Robert , King Andrew , Lukovic Biljana , Berryman Kelvin , Daly Michele
Published: June 2021

Infrastructure networks (e.g. transport, water, energy, telecommunications) support life and the economy of communities of all sizes. New Zealand has witnessed several damaging earthquakes in the last decade that provide a compelling case to accelerate building resilient infrastructures in the country, so we can minimize any adverse impacts from future earthquakes. One of the regions that is highly vulnerable to earthquakes is Wellington. With the region’s population continually expanding and placing increased demands on its ageing infrastructures, with limited redundancy in the networks, and with many of its assets close to and / or intersecting fault lines, a large earthquake in the region could be highly disruptive, potentially resulting in serious social and economic consequences. While it may not be possible to completely avoid the impacts, they can be reduced. This paper provides an overview of the process taken in delivering a Wellington Lifelines Group report that demonstrates how impacts from a future major earthquake can be reduced through integrated and targeted infrastructure resilience investments. To quantify the benefits that can be achieved by making the proposed investments, impact modelling on nine different lifeline utilities in the Wellington metropolitan area were conducted; the assessment approach taken, and results derived and their use to prioritise resilience investments, are shown in this paper for selected key networks. The time-stamped service outage maps and tables produced from this work formed an essential input to evaluate and demonstrate the impact of the proposed resilience initiatives on the regional and national economies.
Expected seismic performance of gravity dams using machine learning techniques
Authors: Segura Rocio , Padgett Jamie , Paultre Patrick
Published: June 2021

Methods for the seismic analysis of dams have improved extensively in the last several decades. Advanced numerical models have become more feasible and constitute the basis of improved procedures for design and assessment. A probabilistic framework is required to manage the various sources of uncertainty that may impact system performance and fragility analysis is a promising approach for depicting conditional probabilities of limit state exceedance under such uncertainties. However, the effect of model parameter variation on the seismic fragility analysis of structures with complex numerical models, such as dams, is frequently overlooked due to the costly and time-consuming revaluation of the numerical model. To improve the seismic assessment of such structures by jointly reducing the computational burden, this study proposes the implementation of a polynomial response surface metamodel to emulate the response of the system. The latter will be computationally and visually validated and used to predict the continuous relative maximum base sliding of the dam in order to build fragility functions and show the effect of modelling parameter variation. The resulting fragility functions are used to assess the seismic performance of the dam and formulate recommendations with respect to the model parameters. To establish admissible ranges of the model parameters in line with the current guidelines for seismic safety, load cases corresponding to return periods for the dam classification are used to attain target performance limit states.
OSCILLATION THEOREMS FOR NONLINEAR SECOND ORDER DIFFERENCE EQUATIONS WITH A NONLINEAR DAMPING TERM
Authors: THANDAPANI E. , PANDIAN S.
Published: June 2021

Some new sufficient conditions for the oscillation of the nonlinear damped second order difference equations of the form

\[\Delta^2 y_n+p_n\phi(y_n, \Delta y_n)+q_nf(y_{n+1})g(\Delta y_n)=0\]

are given.
QUALITATIVE THEORY OF PARTIAL DIFFERENCE EQUATIONS (II): OSCILLATION CRITERIA FOR DIRECT CONTROL SYSTEMS IN SEVERAL VARIABLES
Authors: CHENG SUI SUN , XIE SHENG-LI , ZHANG BING-GEN
Published: June 2021

This paper is concerned with several direct control systems which are described by partial difference equations. By means of an averaging technique and several oscillation criteria for ordinary recurrence relations, we are able to establish several oscillation criteria for these control systems.
A NOTE ON CLASSICAL HILBERT INEQUALITY
Authors: YANG GOU-SHENG , GAU SHYH-LIANG
Published: June 2021

In this note we establish some new generalizations of the classical in­ equality of Hilbert with non-conjugate parameters.
Una secuencia de actividades para desarrollar la visualización usando un videojuego
Authors: Albarracín Lluís
Published: June 2021

Este artículo describe una de secuencia de actividades para trabajar la visualización con alumnos de cuarto de Educación Primaria a partir del contexto promovido por un videojuego tipo puzle tridimensional. La secuencia se inicia jugando libremente para identificar los retos que propone el juego. A continuación, se proponen actividades para identificar aspectos claves del videojuego y generar conocimientos geométricos sobre visualización con el cual poder diseñar niveles del videojuego. En el artículo se presenta cada actividad que conforma la secuencia, su fundamentación y la validación de los aprendizajes promovidos después de su aplicación. Estos resultados ponen de manifiesto las posibilidades del videojuego utilizado y las actividades que lo acompañan para relacionar diferentes formas de visualización de objetos tridimensionales.
Aprendizaje de la equidistancia a través de la variación: un estudio con niños de primaria
Authors: Sandoval Caceres Ivonne Twiggy , Camargo Uribe Leonor
Published: June 2021

Presentamos momentos del aprendizaje de la equidistancia de niños de 10 años, al experimentar la variación de elementos de figuras geométricas. La intervención se realizó en una escuela pública de la Ciudad de México en tres sesiones de 90 minutos cada una. Ellos usaron por primera vez un programa de geometría dinámica para construir y explorar propiedades invariantes de circunferencias, triángulos isósceles y equiláteros. Los resultados, fundamentados en la teoría de la variación, muestran que la experimentación realizada fue significativa para conceptualizar la equidistancia, en contraste con la colinealidad y la congruencia, al resolver problemas de geometría.
A atuação profissional do pedagogo no Centro de Referência Especializado de Assistência Social (CREAS)
Authors: Mendes Márcia Cristiane Ferreira , De Moura Giovanna Barroca , Santos Tatiana De Medeiros
Published: June 2021

This academic article aims to understand the performance of the Pedagogue in the scope of Social Assistance inserted in the Specialized Reference Center for Social Assistance in the state of Paraíba. To better develop the theme, we will follow the paths of Social Pedagogy, which is a reflection to understand the role of the educator in Social Assistance - CREAS. The choice of theme is justified because it perceives the importance of the formation of Pedagogues around Social Pedagogy. As a theoretical foundation, we support the research on the contributions of Saviani (2013) Paula (2014) Souza, et al (2014), Machado, Rodrigues and Severo (2014), PNAS (2004), LOAS (2003) (2011), for describing the advances of their research in the field of education and Social Pedagogy. As a methodological support, we used qualitative research. It is also emphasized that throughout the investigative work we perceive the importance of discussing the Pedagogue's spaces of action beyond the educational scopes.
A Decade of GoMRI Dispersant Science: Lessons Learned and Recommendations for the Future
Authors:   Texas A&M University at Galveston, Quigg Antonietta , Farrington John , Gilbert Sherryl , Murawski Steven , John Vijay
Published: June 2021

Dispersants are among a number of options available to oil spill responders. The goals of this technique are to remove oil from surface waters in order to reduce exposure of surface-dwelling organisms, to keep oil slicks from impacting sensitive shorelines, and to protect responders from volatile organic compounds. During the Deepwater Horizon response, unprecedented volumes of dispersants (Corexit 9500 and 9527) were both sprayed on surface slicks from airplanes and applied directly at the wellhead (~1,500 m water depth). A decade of research followed, leading to a deeper understanding of dispersant effectiveness, fate, and effects. These studies resulted in new knowledge regarding dispersant formulations, efficacy, and effects on organisms and processes at a broad range of exposure levels, and about potential environmental and human impacts. Future studies should focus on the application of high volumes of dispersants subsea and the long-term fate and effects of dispersants and dispersed oil. In considering effects, the research and applications of the knowledge gained should go beyond concerns for acute toxicity and consider sublethal impacts at all levels of biological organization. Contingency planning for the use of dispersants during oil spill response should consider more deeply the temporal duration, effectiveness (especially of subsurface applications), spatial reach, and volume applied.
Transcendentalism as a Program for the Development of Epistemology
Authors: Nevvazhay Igor D. ,   Institute of Philosophy, Russian Academy of Sciences
Published: June 2021

The author discusses some tensions between realism and constructivism in the theory of knowledge and the corresponding research programs in the philosophy of science. In this paper, he argues that the development of transcendentalism can help reduce these tensions. He considers the way for Kant’s transcendentalism development, which is connected with the semiotic interpretation proposed by K.-O. Apel. The author suggests the new interpretation of transcendentalism according to which the transcendental exists as a proto-norm, which is a spontaneous act that assigns the “given” object either the status of a sign reffering to a certain meaning, or the status of a meaning reffering to a certain expression (sign). The author develops G. Frege’s concept of meaning and argues that the existence of two kinds of meaning (meaning-1 and meaning-2), which corresponds with the two fundamental characteristics of consciousness: intensionality and responsiveness. Given this, a transcendental act generates either intensional or responsive meanings of the reality. The proposed symbolic interpretation of transcendentalism allows us explain the emergence of realism and constructivism as semiotic types of cultures and overcome the tensions between them. It is also shown that this version of symbolic transcendentalism is promising for explaining the nature of absolute existences in both classical and non-classical physical theories. The examples of such existences as absolute space and absolute time in Newtonian mechanics and absolute standards in G. Weil's theory of gauge fields are considered. These transcendental existences cannot be interpreted as real physical objects, and at the same time they are necessary for the interpretation of physical experiments. The author comes to the conclusion that transcendentalism is a promising program for the development of philosophy of science as an area for researches in normativity, sign-symbolic structures of cognitive processes, and the forms of knowledge.
Introduction: Modernism and the Turn to Religion
Authors: Woelfel Craig , Stayer Jayme ,   Marquette University Press
Published: June 2021

This Introduction contextualizes the volume in modernist tensions between belief and unbelief, and subsequent debates about the nature of secularization. An opening moment considers Pound and Woolf’s rejection of T. S. Eliot’s religious conversion as emblematic of a “subtraction” theory of secularization, in which secularity and religious belief are taken as mutually exclusive horizons of understanding. Such thinking, it is argued, has precluded a more nuanced approach. Criticism has largely ignored more complex and fragmentary religious dimensions of modernist production; or, on the other hand, taken up religion only in the narrow and anachronistic sense of traditional Christianity. This volume attempts to explore the religious dimensions of modernism in a more modernist sense: taking modernist art as a critical liminal space for exploring new modes of religious experience in complex and resonant ways -- often in open rejection of traditional modes of faith, and in authors beyond the usual suspects.
Wells, Chesterton, and a Theology of Semi-detached Reading
Authors: Knight Mark ,   Marquette University Press
Published: June 2021

This article engages with the work of John Plotz on our experience of being caught between two worlds as we read—a world of fiction that partially absorbs us, and the actual world, to which we remain attached. Noting the lack of attention Plotz pays to religion as he writes about semi-detachment, I respond by developing a theology of semidetached reading. To think through the contribution that theology offers, I turn to two works of fiction: H. G. Wells’s “The Plattner Story” (1896) and G. K. Chesterton’s The Man who was Thursday: A Nightmare (1908). In doing so, I recognize the very different ways in which Wells and Chesterton tease out the strange mix of secular and religious experience that is so important for those who want to understand religion in the modern world. As I go on to argue, paying attention to theology allows to register particular narratives in which people traverse these worlds and seek to hold different threads of meaning together. A theology of semidetached reading can also shed light on the ways in which different worlds are configured, as well as helping us to navigate points of conflict as we move between them.
The Burial of the Dead in Mann’s The Magic Mountain
Authors: Lewis Pericles ,   Marquette University Press
Published: June 2021

During the COVID-19 pandemic of 2020, readers of modernist literature have often been reminded of the flu epidemic of 1918-1920. Thomas Mann’s The Magic Mountain (1924) anatomizes pre-war bourgeois society as represented by the inmates of a tuberculosis asylum in Davos, Switzerland. The novel typifies a concern in modernist fiction with the proper rites for the burial of the dead, which I explored in an earlier study, Religious Experience and the Modernist Novel. This essay argues that that Mann sees the novel, as a genre, as having a particular ability to represent the process of mourning because of its powers of ironic distancing: it can represent both the public ritual of the funeral service and the private thoughts of the mourner, which may or may not accord with official sentiment. More generally, the modern novel shows how we project our own desires and fears onto the dead.
Playing with Fractions
Authors: Dixon Juli K. , Rutledge Treshonda , Caton Jennifer C. , Nolan Edward C.
Published: June 2021

Constraints for social distancing require teachers to find creative ways to engage students. Consider this fun strategy for exploring fraction equivalence, addition, and subtraction in a game environment where students use self-made or digital manipulatives.
Teaching Is a Journey: Can a Teacher Affect Eternity?
Authors: Edwards Thomas G.
Published: June 2021

This department provides a space for current and past PK–12 teachers of mathematics to connect with other teachers of mathematics through their stories that lend personal and professional support.
NIST PSCR :
Authors: Nadeau Lou , Sands Melanie , Lyons Douglas , Berger Clara
Published: June 2021

NIST s Public Safety Communications Research (PSCR) Division is the primary federal laboratory focused on conducting research, development, testing, and evaluation for public safety communications technologies. Their mission is to accelerate communications innovation in support of public safety communities and the citizens they serve. The 2012 Middle Class Tax Relief and Job Creation Act contained landmark provisions for the development and build out of the Nationwide Public Safety Broadband Network (NPSBN) and established The Public Safety Trust Fund (PSTF) to support the design and implementation of the Network. The Act charged the NIST with utilizing up to
Dynamique des « petits mondes » de parties prenantes de l’entreprise. L’exemple des restructurations industrielles
Authors: Ferrary Michel
Published: June 2021

La stratégie politique visant à gérer les parties prenantes de l’entreprise peut être explorée par l’articulation de la théorie des parties prenantes et de l’analyse des réseaux complexes. Les parties prenantes apparaissent comme structurées sous la forme d’un réseau de « petits mondes », c’est-à-dire comme un ensemble de clusters denses faiblement reliés entre eux. Ces réseaux sont soumis à des chocs systémiques aléatoires ou intentionnels qui influencent l’urgence de la situation à laquelle fait face l’entreprise et la légitimité de ses actions. L’encastrement de l’entreprise (fort ou faible) et la nature du choc (aléatoire ou intentionnelle) détermine le choix de l’entreprise entre une stratégie politique réactive, accommodante, proactive ou défensive.
Sociopragmatic variation in attention focus: 'mira', 'fíjate', and 'oye' in San Juan and Mexico City
Authors: Graham Lamar
Published: June 2021

Discourse markers of attention focus (enfocadores de alteridad in Spanish) frequently serve the purposes of drawing the hearer’s attention to what the speaker is saying, either to establish or maintain contact between the two interlocutors.  The current study aims to determine whether the choice of appellative marker is socially or grammatically motivated.  Using sociolinguistic corpora from two major Latin American cities, the study will analyze the variation among the markers.  More specifically, are there extenuating factors that influence whether a speaker elects to use mira, fíjate or oye to focus the attention of the hearer?  The study finds that the choice between markers in San Juan and Mexico City is conditioned by different markers in each locale and, additionally, hints that the style of discourse may have an effect on the prevalence of these markers in general.
Consistent and accurate estimation of stellar parameters from HARPS-N Spectroscopy using Deep Learning
Authors: Hüttel Frederik Boe , Harder Clemmensen Line Katrine
Published: June 2021

Consistent and accurate estimation of stellar parameters is of great importance for information retrieval in astrophysical research. The parameters span a wide range from effective temperature to rotational velocity. We propose to estimate the stellar parameters directly from spectral signals coming from the HARPS-N spectrograph pipeline before any spectrum-processing steps are applied to extract the 1D spectrum. We propose an attention-based model to estimate the stellar parameters, which estimate both mean and uncertainty of the stellar parameters through estimation of the parameters of a Gaussian distribution. The estimated distributions create a basis to generate data-driven Gaussian confidence intervals for the estimated stellar parameters. We show that residual networks and attention-based models can estimate the stellar parameters with high accuracy for low Signal-to-noise ratio (SNR) compared to previous methods. With an observation of the Sun from the HARPS-N spectrograph, we show that the models can estimate stellar parameters from real observational data.
Reducing Objective Function Mismatch in Deep Clustering with the Unsupervised Companion Objective
Authors: Trosten Daniel J. , Jenssen Robert , Kampffmeyer Michael C.
Published: June 2021

Preservation of local similarity structure is a key challenge in deep clustering. Many recent deep clustering methods therefore use autoencoders to help guide the model's neural network towards an embedding which is more reflective of the input space geometry. However, recent work has shown that autoencoder-based deep clustering models can suffer from objective function mismatch (OFM). In order to improve the preservation of local similarity structure, while simultaneously having a low OFM, we develop a new auxiliary objective function for deep clustering. Our Unsupervised Companion Objective (UCO) encourages a consistent clustering structure at intermediate layers in the network -- helping the network learn an embedding which is more reflective of the similarity structure in the input space. Since a clustering-based auxiliary objective has the same goal as the main clustering objective, it is less prone to introduce objective function mismatch between itself and the main objective. Our experiments show that attaching the UCO to a deep clustering model improves the performance of the model, and exhibits a lower OFM, compared to an analogous autoencoder-based model.
Comparison of body temperature and heart rate in sea turtles from Baja California Sur, Mexico
Authors: Fernández-Sanz Helena , Reséndiz Eduardo
Published: June 2021

Sea turtles depend on ambient temperature to carry out their main activities, so changes in water temperature can affect the function of their immune system and represent different threats. To assess vital signs in black sea turtles (Chelonia mydas) in the Ojo de Liebre lagoon complex, Mexico, 600 turtles were examined. Carapace, plastron, and left inguinal area temperatures were measured with a digital infrared thermometer gun. Cloacal temperature was measured with an electronic thermometer. Heart rate was recorded using a stethoscope. Statistical analyses found no significant variation between inguinal area and cloacal temperatures. Vital sign measurements were compared with previous reports in the region, and there were differences in body temperatures, which were attributed to the characteristics of the water masses inhabited by the turtles. There was no significant difference between heart rate data for black sea turtles in this study and previously reported data for healthy sea turtles in the region, indicating that these data are likely an accurate representation for the species. All values fell within the reference intervals for healthy sea turtles. This minimally invasive diagnostic approach using vital signs allowed us to evaluate and infer core organ functions and to rule out health threats such as cold-stunning, resulting in a useful preliminary systemic assessment of free-ranging sea turtles.
Spectroscopic studies and molecular docking on the interaction of delphinidin‐3‐O‐galactoside with tyrosinase
Authors: Chen Rongda , Shi Yurui , Liu Guiming , Tao Yanzhou , Fan Yangyang , Wang Xiaolin , Li Li
Published: June 2021

The inhibitory effects of delphinidin‐3‐O‐galactoside (DG) on the activities of tyrosinase (EC 1.14.18.1) (TY) from the edible Agaricus bisporus mushroom were investigated by enzyme kinetics, multispectroscopic methods, and molecular docking. As a result, DG showed strong inhibition on TY with the IC50 of 34.14 × 10–6 mol L–1. The inhibition mode of DG against TY was mixed type with α values of 5.09. The binding constant Ka and related thermodynamic parameters at the three different temperatures showed that the fluorescence quenching of TY by DG was static quenching. Synchronous fluorescence, three‐dimensional fluorescence, ultraviolet–visible spectroscopy, and circular dichroism spectroscopies confirmed that the conformation or microenvironment of the TY protein were changed after binding with DG. Molecular docking revealed that DG had strong binding affinity to TY through hydrogen bonding and van der Waals force, and the results were consistent with the fluorescence data. Our findings suggested that DG may be potential TY inhibitor.
Spinal cord regeneration: A brief overview of the present scenario and a sneak peek into the future
Authors: Srivastava Ekta , Singh Anamika , Kumar Ashok
Published: June 2021

The central nervous system (CNS) portrays appreciable complexity in developing from a neural tube to controlling major functions of the body and orchestrated co‐ordination in maintaining its homeostasis. Any insult or pathology to such an organized tissue leads to a plethora of events ranging from local hypoxia, ischemia, oxidative stress to reactive gliosis and scarring. Despite unravelling the pathophysiology of spinal cord injury (SCI) and linked cellular and molecular mechanism, the over exhaustive inflammatory response at the site of injury, limited intrinsic regeneration capability of CNS, and the dual role of glial scar halts the expected accomplishment. The review discusses major current treatment approaches for traumatic SCI, addressing their limitation and scope for further development in the field under three main categories‐ neuroprotection, neuro‐regeneration, and neuroplasticity. We further propose that a multi‐disciplinary combinatorial treatment approach exploring any two or all three heads simultaneously might alleviate the inhibitory milieu and ameliorate functional recovery.
A fast, cost‐saving and sensitive method for determination of cefuroxime in plasma by HPLC with ultraviolet detection
Authors: Hernandis Verónica , Escudero Elisa , Pareja Ana , Marín Pedro
Published: June 2021

Cefuroxime (CFX) is a broad‐spectrum second‐generation cephalosporin and one of the best choices for antibiotic prophylaxis. However, when used in critically ill patients, it may present changes in its pharmacokinetic properties. Therefore, therapeutic drug monitoring of CFX is necessary for effective dosing strategies. A simple, rapid and sensitive liquid chromatographic method with UV detection was developed and validated for the quantification of CFX in plasma. The method involved a single‐step precipitation of proteins with methanol and trifluoroacetic acid. Cefuroxime was analyzed on a Brisa LC2C18column in isocratic mode consisting of 0.1% trifluoroacetic acid in water and acetonitrile (75:25) with UV detection at a wavelength of 280 nm. The retention times of CFX and cephazolin (internal standard) were 9.8 and 7.4 min, respectively. The calibration curve was linear over a concentration range of 0.25–50 μg/ml. The limits of detection and quantification were 0.1 μg/ml and 0.25 μg/ml, respectively. The accuracy and precision were always <10%. The mean recovery was 93.52%. This fast and simple method could be applied in routine analysis and pharmacokinetic studies.
Chemical Constituent, Antimicrobial Activity, and Synergistic Effect of the Stem, Leaf, and Flower Essential Oil of the Artemisia fragrans Willd. from Khoy
Authors: Aminkhani Ali , Sharifi Sina , Hosseinzadeh Pourya
Published: June 2021

Artemisia fragrans is commonly used as a folk medicine as antispasmodic, anti‐pyretic, anti‐inflammatory, and abortifacient agents. The villagers use its pungent odor to repel rodents, mites, and pests, as well as its essential oil and smoke after burning to treat lung infections after uprooting the plant. Herein, we extracted the essential oils (EOs) of different parts of the plant and analyzed their chemical compositions and antibacterial activities. The chemical analysis led to the identification of 73, 59, and 57 compounds in the EOs of the stem, leaf, and flower, respectively. All of the EOs exhibited antibacterial activities against both G+ and G− bacteria. The EOs of the leaf and flower were more effective against tested bacteria, except B. anthracis and P. aeruginosa, compared to that of the stem. The binary combination of the EOs (stem and flower) or (stem and leaf) showed a synergistic effect. Statistical analysis indicated EOs of leaf and flower are more potent than that of the stem. These findings suggest the application of leaf and flower of the plant, which not only can prevent its uprooting but also ensure better therapeutic function.
Propensity‐matched comparison of large‐bore access closure in transcatheter aortic valve replacement using MANTA versus Perclose: A real‐world experience
Authors: Medranda Giorgio A. , Case Brian C. , Zhang Cheng , Rappaport Hank , Weissman Gaby , Bernardo Nelson L. , Satler Lowell F. , Ben‐Dor Itsik , Rogers Toby , Waksman Ron
Published: June 2021

Objective

Compare two large‐bore vascular closure devices (VCDs), collagen‐plug‐based MANTA and suture‐based dual Perclose ProGlide (PP), in patients undergoing contemporary transfemoral transcatheter aortic valve replacement (TAVR).

Background

The SAFE MANTA IDE clinical trial demonstrated that the collagen‐plug‐based MANTA VCDs were safe and effective in closing large‐bore arteriotomies. However, data comparing this collagen‐plug‐based VCD to the suture‐based VCD in contemporary practice are sparse.

Methods

This was a retrospective observational study in which we screened transfemoral (TF) TAVR patients at our institution from 2017 to 2020. Included were those whose large‐bore TF access was closed using either MANTA or PP with and without Angio‐Seal. Our primary outcome was VCD success. Additional in‐hospital outcomes included major and minor vascular complications, post‐TAVR length of stay, and mortality.

Results

We screened 696 patients who underwent TAVR. Using propensity scores, we matched 124 patients who received MANTA with 124 patients who received PP. Patients had a mean age of 77.2 years, 69.0% were men, and their mean Society of Thoracic Surgeons score was 3.4%. VCD success was equivalent between VCDs (95.2% vs. 95.2%; p = 1.000). Patients had similar rates of mortality (0% vs. 0.8%; p = .316), and no patients had major vascular complications.

Conclusions

In contemporary TAVR, the collagen‐plug‐based MANTA VCD appears to be as safe and effective as the suture‐based dual PP VCD, with no differences in VCD success, vascular complications, or mortality. Therefore, selection of VCD for TAVR should be left to operator discretion, taking into account anatomical considerations.
Learning, experiences, and actions towards advancing gender equity in engineering as aspiring men's allyship group
Authors: Wilson Nicole L. , Dance Torrey , Pei Winston , Sanders R. Sean , Ulrich Ania C.
Published: June 2021

The representation of women in the engineering profession (17.90%) far lags that of the Canadian workforce (47.50%), with several authors citing the need for professional and organizational culture change for engineering to be more equitable for and inclusive of women. Recent evidence reported that men actively working on gender equity practices is one mechanism through which this culture change will occur. The practice of allyship by men involves learning and reflecting, building trusting relationships with women colleagues, continuous action even through discomfort, and influencing change at multiple levels. We share our own experiences with starting a men's allyship group in an engineering workplace, initial successes, opportunities to improve, and our vision for the future.