bluuebunny/crossref_metadata_2025 huggingface dataset:
Impactos ambientales y efectos en la salud en el entorno del Río Hondo, Cauca
Authors: Castro-Montaño Carmen D , Gil Pardo Daniela , Samboní-Valverde María H , Muñoz-Solarte Diana M
Published: October 2024

Introducción: la comunidad de la vereda El Salvador no cuenta con un sistema de alcantarillado, lo que provoca el vertido de aguas residuales directamente al río Hondo sin ningún tipo de tratamiento. Los habitantes de la zona desconocen los impactos ambientales y los riesgos para la salud que esta práctica conlleva.Objetivo: el propósito de este estudio fue identificar los impactos ambientales y los síntomas de salud en el entorno del río Hondo que cruza a través de la vereda.Métodos: para la recolección de información, se establecieron dos fases metodológicas. En la primera fase, se identificaron los aspectos ambientales asociados a la calidad del agua del río Hondo mediante una lista de chequeo y una matriz de Leopold. La segunda fase consistió en determinar los síntomas de salud relacionados con los factores ambientales del lugar, para lo cual se aplicó una encuesta a una muestra poblacional de 60 personas.Resultados: se evidenció un 87.5% de no cumplimiento versus un 12.5% de cumplimiento de los factores ambientales, lo que indica un mayor porcentaje de afectación al medio ambiente en relación con la calidad del agua, uso del suelo, biodiversidad, fuentes de contaminación, regulaciones e impactos a la salud humana. La mala disposición de residuos y la falta de gestión de un sistema de alcantarillado intensifican los problemas ambientales y de salud en los habitantes del sector. Los síntomas más frecuentes reportados en la encuesta fueron daño y dolor de estómago e infecciones intestinales (46.7%), seguidos por la enfermedad del dengue (43.3%), chikunguña (3.3%) y malaria (3.3%).Conclusión: la ausencia de un sistema adecuado de alcantarillado y la disposición inadecuada de residuos contribuyen significativamente a los problemas ambientales y de salud en la comunidad de la vereda El Salvador. Es crucial implementar medidas de gestión ambiental y de salud pública para mitigar estos efectos adversos.
Pemanfaatan Ekstrak Daun Jambu Air Varitas King Rose (Syzygium Aqueum Burn.F.Alston) Terhadap Intensitas Serangan Serangga Hama Pada Tanaman Sawi Hijau (Brassica Juncea. L)
Authors: Aprilia Fiona Esther , Lumowa Sonja Verra Tinneke , Purwati Sri , Pribadi Teguh
Published: October 2024

Tujuan Penelitian ini adalah melihat pengaruh ekstrak daun jambu air king rose (Syzygium Aqueum Burn.F.Alston) dan konsentrasi maksimal terhadap intensitas serangan serangga hama pada tanaman sawi hijau (Brassica juncea. L).Jenis penelitian ini adalah eksperimen, Teknik yang digunakan dalam pengambilan sampel pada penelitian ini adalah jenis pengambilan sampel probabilitas yaitu sampel acak sederhana (Simple random sampling). Berdasarkan hasil penelitian dapat dilihat pada tabel intensitas serangan serangga hama usia 11 HST, 18 HST, 25 HST, 32 HST, 39 HST mengalami penurunan kerusakan disetiap perlakuan ekstrak daun jambu air king rose yang diaplikasikan pada tanaman sawi hijau. Hal tersebut membuktikan bahwa ekstrak daun jambu air king rose dapat menekan serangan serangga hama pada tanaman sawi hijau. terdapat pengaruh ekstrak daun jambu air king rose (Syzygium Aqueum Burn.F.Alston) terhadap intensitas serangan serangga hama pada tanaman sawi hijau (Brassica juncea. L). Konsentrasi ekstrak daun jambu air king rose (Syzygium Aqueum Burn.F.Alston) yang paling efektif sebagai pestisida nabati pada tanaman sawi hijau (Brassica juncea. L) adalah konsentrasi 40% (T4)
Pengaruh Model Project Based Learning (PJBL) Terhadap Keterampilan Berpikir Tingkat Tinggi (Hots) Siswa Smas Budisatrya Pada Materi Ekosistem
Authors: Habibunnisa Habibunnisa , Manalu Kartika , Jayanti Ummi
Published: October 2024

Penelitian ini bertujuan untuk meningkatkan keterampilan berpikir tingkat tinggi siswa melalui model pembelajaran Project Based Learning (PjBL) pada materi ekosistem di SMAS Budisatrya. Jenis penelitian ni adalah quasi eksperimen dengan bentuk desain non equivalent control grup desain. Populasi penelitian ini adalah seluruh siswa kelas X SMAS Budisatrya yang terdiri dari 2 kelas dengan jumlah 71 siswa. Sampel penelitian menggunakan teknik Total Sampling terdiri dari dua kelas yaitu X2 berjumlah 36 siswa sebagai kelas eksperimen dan X1 berjumlah 35 siswa sebagai kelas kontrol. Instrumen penelitian ini menggunakan tes pilihan ganda yang terdiri dari 20 soal untuk mengukur keterampilan berpikir tingkat tinggi siswa. Hipotesis penelitian ini menggunakan uji  Independent sample t-test diketahui nilai Sig. (2-tailed) pada data posttest dengan nilai Sig. (2-tailed) sebesar 0,000 < 0,05 sehingga dapat disimpulkan bahwa H0 ditolak dan Ha diterima. Sehingga terdapat pengaruh model pembelajaran project based learning terhadap keterampilan berpikir tingkat tinggi (HOTS) pada materi ekosistem siswa SMAS Budisatrya. Kata kunci: Project Based Learning, Berpikir Tingkat Tinggi (HOTS), Ekosistem
Pengembangan Media Pembelajaran E-Komik pada Mata Pelajaran Biologi Bagi Siswa SMA
Authors: Ayu Mughnita , Nursamsu Nursamsu , Mahyuny Siska Rita
Published: October 2024

Penelitian ini bertujuan untuk mengembangkan media pembelajaran e-komik pada materi sistem pencernaan terkait pada kemampuan berfikir kreatif peserta didik. Metode penelitian yang digunakan dalam penelitian ini adalah metode R&D  dengan model pengembangan ADDIE. Penelitian ini diuji cobakan secara terbatas pada peserta didik kelas XI F A SMA Negeri 1 Langsa. Instrumen yang digunakan dalam penelitian ini adalah lembar validasi oleh para ahli, angket kepraktisan oleh guru serta angket respon peserta didik. Hasil penelitian berupa media pembelajaran berupa e-komik dengan penilaian tingkat validasi rata-rata sebesar 81,9% dengan kriteria “sangat baik”, penilaian dari ahli materi diperoleh rata-rata presentase sebesar 94,6% dengan kriteria “sangat baik” , demikian media pembelajaran e-komik sangat valid dan sangat layak untuk digunakan. Serta tingkat kepraktisan media pembelajaran e-komik dari guru mata pelajaran biologi kelas XI SMA Negeri 1 Langsa diperoleh rata-rata presentase 97,1% dengan kategori “sangat baik” dan respon dari peserta didik terhadap media e-komik sebesar 88,9% dengan kriteria “sangat baik”. Berdasarkan hasil penelitian dapat disimpulkan bahwa media pembelajaran e-komik yang dikembangkan valid dan praktis digunakan di dalam proses pembelajaran.Kata kunci: E-Komik, Media Pembelajaran, Pengembangan
Analisis Biosafety dan Biosecurity Laboratorium Biologi MAN X Jakarta
Authors: Nurjannah An Nabilla , Siregar Maya Srinarti , Azizah Nadia Nur , Maesaroh Siti , Muliyah Evi
Published: October 2024

Pelaksanaan kegiatan praktikum di dalam laboratorium biologi harus mengikuti aturan yang ada di dalam laboratorium, salah satunya penerapan aspek-aspek biosafety dan biosecurity selama beraktivitas di dalam laboratorium. Penelitian ini bertujuan untuk mengetahui kondisi laboratorium biologi di MAN X Jakarta dan mengidentifikasi kelengkapan sarana dan prasarana, terutama pada aspek biosafety dan biosecurity. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kuantitatif melalui angket, observasi, wawancara, dan dokumentasi. Analisis data secara kualitatif disajikan dalam bentuk deskriptif berdasarkan hasil wawancara. Analisis kuantitatif dilakukan dengan perhitungan kuantitatif dalam bentuk persentase. Berdasarkan hasil observasi, kondisi laboratorium biologi MAN X Jakarta termasuk kategori sangat lengkap, memiliki sarana prasarana biosafety dan biosecurity yang lengkap dengan persentase 66,67% serta pengelolaan biosafety dan biosecurity yang sangat baik.
Frequency of t(11;22)(q24;q12) in Ewing’s Sarcoma using Fluorescence in Situ Hybridisation Technique
Authors: Gadhia P. K. , Vaniawala Salil
Published: October 2024

Objectives:

Ewing’s sarcoma (ES) is a rare and aggressive cancer that primarily affects bone and adjacent soft tissues. It is characterised by the presence of the chromosomal translocation t(11;22)(q24;q12) in approximately 85–90% of cases. This translocation leads to the fusion of the EWSR1 gene on chromosome 22 with the FLI1 gene on chromosome 11, resulting in the production of the EWSR1-FLI1 fusion protein, which is crucial for oncogenesis. This research aims to investigate EWSR1 gene translocation using fluorescence in situ hybridisation (FISH).

Materials and Methods:

The study evaluated the prevalence of EWSR1 rearrangements using FISH. We analysed 39 tumour samples with the EWSR1 Dual Color Break Apart Probe Kit.

Results:

The study included 39 suspected cases of ES, comprising 21 males (53.8%) and 18 females (46.2%), with a median age of 17 years. Out of these, 11 males and eight females tested positive for ES.

Conclusion:

The study highlights the importance of FISH as a diagnostic tool for ES and its potential in differentiating ES from other small round-cell tumours.
Assessing the Impact of an Intervention on Caregivers’ Awareness and Completion of Continuum of Care Among Pregnant Women
Authors: Aung May Soe , Soe Myint Moh , Win Hla Hla , Mya Kyaw Swa
Published: October 2024

Background and Objective

The continuum of care (CoC) is an important approach that should be prioritized for improving maternal health. The World Health Organization recommends working with individuals, families, and communities to ensure continuous care throughout pregnancy, childbirth, and the postpartum period. The purpose of this study was to assess the impact of an intervention on the awareness of the CoC among main caregivers and the completion of CoC among pregnant women.

Methods

During the COVID-19 pandemic, a community-based quasi-experimental study was conducted in two townships of the Yangon Region, including 200 pairs of pregnant women and their caregivers. The intervention focused on providing health education sessions and distributing pamphlets to caregivers in the intervention group. The study aimed to assess the awareness of main caregivers about CoC and completion of CoC among pregnant women. A key predictor variable for evaluating the outcome was receiving an intervention package by the main caregivers in the intervention. The analysis used logistic regression, including the propensity score model, and was conducted using STATA vs 15.1.

Results

The final analysis included 193 pairs. Most main caregivers were husbands: 47 were husbands in the intervention and 59 in the control group, while 24 mothers were included in both groups. The awareness of CoC for maternal health among main caregivers from the intervention group was 9.97 times higher than those from the control group (AOR = 9.97, 95% CI: 5.12 to 19.43, p < 0.001). The completion of CoC among women from the intervention group was 2.17 times higher than those from the controls (AOR = 2.17, 95% CI 1.08 to 4.37, p < 0.05). The awareness of main caregivers was found to be a significant predictor for completion of CoC.

Conclusion and Global Health Implications

Health education intervention for main caregivers could improve CoC completion among pregnant women. It provided baseline information for further interventions at the family level for improving CoC among pregnant women in the future.
Effectiveness of intralesional bleomycin in the management of difficult-to-treat and resistant cutaneous warts in a tertiary care teaching hospital in Puducherry: A quasi-experimental study
Authors: Singh Yogindher , Rajamohanan Remya Raj , Vasudevan Senthilvel , Kuruvila Sheela
Published: October 2024

Objectives:

The objective of this study was to determine the effectiveness of intralesional injection of bleomycin in the management of difficult-to-treat and resistant cutaneous warts.

Material and Methods:

A total of 54 patients were enrolled in the study, of whom 52 completed it. We administered 0.1% bleomycin over the warts and conducted follow-up at 4, 8, and 12 weeks. If the warts were not completely clear, we administered the next dose of intralesional bleomycin at each visit until the third visit. If the lesions resolved at the third visit, we conducted a telephonic interview for the next follow-up at the end of 12 weeks to record any recurrence of warts and residual side effects.

Results:

Out of 54 patients enrolled in the study, two were lost to follow-up. About 49 (94.2%) patients had clearance of warts at the end of the study period. About 45 (86.5%) patients had complete resolution of lesions after the first session. Three patients achieved complete clearance after the second treatment session. One patient achieved complete clearance at the end of the 12th week. One patient showed a partial response at the end of the 12-week treatment. There was no response for two patients at the end of 12 weeks. Two patients were lost to follow-up.

Conclusion:

The present study demonstrates that intralesional bleomycin is an efficient and safe treatment option in the management of resistant and difficult-to-treat warts.
FEATURES OF SPATIAL THREATS DISPLAY IN THE 2D MODE INDICATION IN ONDOARD COMPLEXES OF AIRCRAFT
Authors: Сазонова Т.В. , Шелагурова М.С.
Published: October 2024

В статье предложена библиотека условных знаков точечных пространственных угроз для 2D индикации, выделено понятие площадных пространственных угроз и методы отображения их на 2D карте. При этом представлены два способа отображения плановой основы: в виде цифровой векторной карты и в виде оттененного рельефа. Для точечных угроз предложена концепция их отображения в режиме 2D индикации в зависимости от масштаба для цифровых векторных карт или уровня детализации для оттененного рельефа. Представлены результаты программно-математического моделирования.

The library of conventional signs of pointed spatial threats for 2D indication is offered in the article, the concept of areal spatial threats and methods of their display on the 2D map is allocated. At the same time two ways of planned basis display are presented: in the form of the digital vector map and in the form of the shaded relief. For pointed threats the concept of their display in the 2D indication mode depending on scale for digital vector maps or detail level for the shaded relief is offered. Results of program and mathematical modeling are presented.
MODIFIED ALGORITHM OF PARTICLE SWARM OPTIMIZATION, FOCUSED ON THE TASK OF MONITORING BY A GROUP OF ROBOTS
Authors: Кан Л. , Карпенко А.П.
Published: October 2024

В работе предложен новый алгоритм глобальной оптимизации PSO+, который представляет собой модификацию канонического алгоритма роя частиц PSO. Модификация направлена на обеспечение возможности использования алгоритма PSO+ для решения задач групповой робототехники, сводящихся к локализации глобального экстремума некоторой скалярной целевой функции. Модификация заключается в ограничении скорости частиц популяции и, главное, в замене концепции близости частиц: вместо близости в топологическом пространстве, используемом алгоритмом PSO, алгоритм PSO+ построен на основе близости частиц в пространстве поиска.

The paper proposes a new algorithm named PSO+ for global optimization, which is a modification of the canonical algorithm PSO for the swarm of particles. The modification is aimed at ensuring the possibility of using the algorithm PSO+ for solving problems of group robotics, which boil down to localizing the global extreme of a certain scalar objective function. The modification consists in limiting the particle velocity and, most importantly, in replacing the concept of particle proximity: instead of proximity in the topological space used by the algorithm PSO, the algorithm PSO+ is based on the proximity of particles in the search space.
Role of Abdominal Drain Post Open Appendectomy for Perforated Appendicitis Among acute appendicitis patients admitted to surgical ward in Al-Thawra Modern General Hospital and Al-Kuwait University Hospital from march 2022 to march 2023
Authors: Issa Mohammed Ali , Obadiel Yasser Abdurabu , Al-Tanobi Abdulbaset Ahmed Hasen
Published: October 2024

Background : Acute appendicitis is the most common cause of surgical  acute  abdomen. Perforation of appendicitis is associated with increase risk of postoperative complications and mortality. Routine peritoneal drainage after appendectomy for perforated appendicitis remains a topic of debate. Objectives: To evaluate the benefit of abdominal drainage post open appendectomy for perforated appendicitis and to study the impact of abdominal drainage on post-operative complications and on length of hospital stay. Methods:  A cross-sectional, observational, prospective study  was conducted among 85 Patients with perforated appendicitis who underwent  open appendectomy Al-Thawra Modern General Hospital and Al-Kuwait University Hospital in Sana'a city from March  2022 to March 2023..Data was analyzed using the statistic package SPSS 23. Results: 85 patients were classified into two groups based on intra-operative insertion of abdominal drainage. There were 50 patients in the drain group compared to 35 patients in the no-drain group. In both groups, majority of patients were male. Most of patients in both groups were in the age group (11-25 years). The main complain of patients was pain, which started around umbilicus, then shifted to right iliac fossa. All patients in both group had tenderness in right iliac fossa. Fever and rebound tenderness were prominent signs in both groups. Leukocytosis was present in 68 % of patients in the drain group compared to 80% in the no drain group. Most of patients in both groups had longer duration of symptoms for three days and more. The tip of appendix was the most common site of perforation in both groups. Surgical site infection occurred in 5 patients (10%) in the drain group compared to 2 patients (5.7%) in the no-drain group. Intra-abdominal abscess occurred in one patient in each the drain group and the no-drain group. Postoperative ileus occurred in one patient in  the drain group compared to no patients in the no-drain group.
Encapsulation of degraded DNA in alginate hydrogels: rheological characterization and applicability to forensic science
Authors: Elliott Colin , Stotesbury Theresa
Published: October 2024

Forensic biomaterials are on the rise, with efforts in developing ex vivo tissue and blood mimetics. Incorporation of small and degraded DNA into these materials has implications for research and training across many areas of forensic science. Large fragments of highly concentrated genomic and phage DNA in solution have been characterized using rheology; however, this amount and size of DNA are atypical in DNA extracted from forensic evidence. In this work, we investigated how adding synthetic DNA oligos and genomic DNA extracted from bloodstains deposited for up to 19 months influenced the rheological properties of polymer systems intended for forensic biomaterial synthesis. We found that encapsulating DNA within an alginate-based, ionically crosslinked hydrogel produced the greatest differentiation in rheological profiles among DNA with varying physical properties. The different conformations and sizes of encapsulated DNA oligos exhibited significantly different responses during strain amplitude sweeps (p<0.05). We also observed moderate correlations between the rheological responses and the time since deposition of bloodstains used for DNA extraction (r = -0.57 to r = 0.62). This indicates that dilute, polydisperse and degraded genomic DNA extracts can effectively modulate the rheological properties of the encapsulating hydrogel. Our results demonstrate the viability of using rheology as a technique to analyze encapsulated dilute DNA oligos and degraded DNA while highlighting the need to consider the type of oligos included in forensic biomaterials.
Machine Learning-Driven Discovery of Highly Selective Antifungal Peptides Containing Non-Canonical β-Amino Acids
Authors: Chang Douglas , Richardson Joshua , Lee Myung-Ryul , Lynn David , Palecek Sean , Van Lehn Reid
Published: October 2024

Antimicrobial peptides (AMPs) are promising compounds for the treatment and prevention of multidrug-resistant infections because of their ability to directly disrupt microbial membranes, a mechanism that is less likely to lead to resistance compared to antibiotics. Unfortunately, natural AMPs are prone to proteolytic cleavage in vivo and have relatively low selectivity for microbial versus human cells, motivating the development of synthetic peptidomimetics of AMPs with improved peptide stability, activity, and selectivity. However, a lack of understanding of structure-activity relationships for peptidomimetics constrains development to rational design or experimental predictors, both of which are cost and time prohibitive, especially when the design space of possible sequences scales exponentially with the number of amino acids. To address these challenges, we developed an iterative Gaussian process regression (GPR) approach to explore a large design space of 336,000 synthetic α/β-peptide analogues of a natural AMP, aurein 1.2, based on an initial training set of 147 sequences and their biological activities against microbial pathogens and selectivity for microbes vs. mammalian cells. We show that the quantification of prediction uncertainty provided by GPR can guide the exploration of this design space via iterative experimental measurements to efficiently discover novel sequences with up to a 52-fold increase in antifungal selectivity compared to aurein 1.2. The highest selectivity peptide discovered using this approach features an unconventional amino-acid substitution strategy that was previously unseen by the model and would be unlikely to be explored by conventional rational design. Overall, this work demonstrates a generalizable approach that integrates computation and experiment to accurately predict the selectivity of AMPs containing synthetic amino acids, which we employed to discover new α/β-peptides that hold promise as selective antifungal agents to combat the antimicrobial resistance crisis.
Entropy-driven supramolecular glass processed under ambient heating
Authors: Liu Zixuan , Wang Lin , Yang Yang , Meng Peng , Wang Xiaodong , Meng Hang , Wang Hongxia , Liu Xiaofeng , Xu Jingsan
Published: October 2024

Glass is an indispensable material in both industrial manufacturing and everyday life. Its development has spanned from traditional silicate glasses to advanced forms such as polymers, amorphous metals, and organic or hybrid glasses. Herein, a novel benzoguanamine-derived supramolecular glass (BGG) is synthesized through a straightforward process: a commercially available molecule is heated in an ambient environment, which condenses into a series of oligomers and forms a melted and homogenous matter. The high-entropy nature of the liquid intermediate is highly unfavorable to crystallization, as a result, natural cooling allows for curing and leads to the formation of rigid supramolecular glass, which is reminiscent of the traditional procedures of inorganic glass production. The prepared BGG features remarkable optical properties and ease of manipulation and scalability, which renders it an excellent candidate for applications in films and fibers for photovoltaics and photonic waveguides. Furthermore, various energy-transfer hybrids are developed based on the BGG framework, including solid solutions with fluorescent molecules and core-shell nanocomposites integrated with perovskite particles, which showcases its versatility as a platform for creating advanced materials with tailored properties.
An Improved P(V) Oligonucleotide Synthesis Platform
Authors: Nassir Molhm , Gherardi Luca , Redman Richard L. , Jin Yonghao , Yao Feng , Yang Yang , Raheja Nicholas , Natarajan Arjun , Butler David , Knouse Kyle W. , Baran Phil S.
Published: October 2024

Three critical advances in simplifying the adoption of P(V)-based stereopure, phosphorothioate-containing oligonu-cleotide synthesis are reported. A more inexpensive phosphorus-sulfur incorporation reagent (Ψ-Br) is introduced, a robust linker system was developed, and a systematic study of common nucleobase protecting groups performed to significantly reduce the barrier to adoption of this technology.
Oligolysine Promotes and Inhibits DNA Condensate Formation
Authors: Ohno Hiroaki , Mabuchi Takuya , Ochi Yosuke , Taira Junichi , Sato Yusuke
Published: October 2024

The formation of biomolecular condensates via phase separation relates to various cellular functions. Reconstituting these condensates with designed molecules allows for exploring their mechanisms and potential applications. Sequence-designed DNA nanostructures enable the investigation of the effects of structural design on condensate formation and construction of functional artificial condensates. Despite the high designability of DNA-based condensates, the presence of free nanostructures that do not assemble into condensates remains a challenge. Herein, we report the effects of cationic oligolysines on DNA condensate formation assembled from Y-shaped DNA nanostructures. Experimental results showed that DNA condensate formation was enhanced by adding oligolysines at an appropriate N/P ratio, the ratio of positively-charged amine groups (N) to negatively-charged nucleic acid phosphate groups (P), maintaining the sequence specificity of DNA. On the other hand, surprisingly, oligolysines significantly inhibited condensate formation depending on the N/P ratio and residue number, which was likely attributed to the deformation of the nanostructures induced by oligolysines. These results suggested that the amount and length of cationic peptides significantly affected the self-assembly of branched DNA nanostructures. We believe that this study will deepen our understanding of biomolecular condensates and provide insights for further development of DNA/peptide hybrid condensates to enhance the functions of artificial condensates for use in artificial cells and molecular robots.
Computationally Complemented Insights into New Generation Solvents for Radiation-Induced Graft Polymerization
Authors: Matsubara Kiho , Nirazuka Tooru , Takahashi Kei , Matsuda Takeshi , Kuroiwa Minoru , Omichi Masaaki , Seko Noriaki , Kakuchi Ryohei
Published: October 2024

This study explores the integration of new generation solvents into radiation-induced graft polymerization (RIGP) processes to enhance sustainable materials chemistry. While RIGP is a valuable technique for surface modification without impacting material properties, the adoption of environmentally friendly solvents has been limited due to their higher costs and underdeveloped chemistry. To address this, a machine learning (ML) approach, utilizing Grimme's GFN-xTB semiempirical method, is employed to predict solvent effects on RIGP. By analyzing molecular properties of conventional solvents, the study aims to provide insights into the chemistry of new generation solvents, facilitating their broader application in sustainable material fabrication.
Collusion in Repeated Auctions with Costless Communication
Authors: Pinheiro Roberto B.
Published: October 2024

In this paper, we present a model of repeated first-price private value auctions in which the bidders have access to a cheap talk communication mechanism. In this framework, messages allow bidders to transmit their preference rankings over the goods to be auctioned, similar to Pesendorfer (2000). We show that collusion through this static mechanism not only dominates the static bid rotation mechanism presented by McAfee and McMillan (1992), but it is also not strictly dominated by the dynamic bid rotation mechanism presented by Aoyagi (2003). However, we show that asymptotic efficiency of collusion through increasing the number of ordered goods, presented by Pesendorfer (2000), demands patience rates to asymptotically approach one, making collusion increasingly more difficult to sustain. Finally, we study mechanisms through which the auctioneer may try to break bidders' collusion.
Evaluasi Faktor-Faktor Putus Pengobatan Pasien TB di Kota Bandar Lampung
Authors: Tuntun Maria , Aminah Siti , Yusrizal Yusrizal
Published: October 2024

Latar Belakang: Kasus TB yang terus meningkat dari tahun ke tahun, perlu mendapat perhatian serius. Pemerintah telah mencanangkan bebas TB di tahun 2050, hal ini semakin mendorong masyarakat untuk mensukseskan program tersebut. Salah satu penanggulangan penyakit TB adalah mengatasi kegagalan pengobatan pasien TB. Metode: Jenis penelitiannya kualitatif analitik, desain case control. Populasinya seluruh pasien TB yang gagal pengobatan dan tercatat pada buku register TB 04. Sampel pada kelompok kasus adalah pasien TB yang gagal pengobatan sebanyak 35 pasien, kelompok kontrolnya yaitu pasien TB yang selesai pengobatan sebanyak 35 pasien. Pengumpulan data menggunakan kuisoner. Pengolahan data menggunakan uji Chi square dan analisis multivariate. Hasil penelitian didapatkan pasien TB sebagai kelompok kasus terbanyak dengan jenis kelamin laki-laki (68,57%), berumur produktif (57,14%), berpendidikan dasar (48,57%), bekerja sebagai buruh/wiraswasta (54,29%), terbanyak berpenghasilan 1-3 juta perbulannya (37,14%), tidak merokok (62,86%), mempunyai PMO (91,43%), jarak rumah pasien TB ke PKM 1-2 km sebanyak 74,29%, ada dukungan keluarga (97,14%), serta kunjungan pasien TB ke PKM yang sesuai sebanyak 54,29%. Dari semua faktor tersebut, yang mempunyai hubungan dengan kegagalan pengobatan pasien TB yaitu jarak ke puskesmas dan kunjungan ke puskesmas dengan p value < 0,05. Saran: puskesmas agar lebih mengawasi pasien TB yang tidak aktif dalam pengobatan.
Evaluation of sensory acceptance and anti-hypercholesterolemia activity of
biscuits containing anthocyanins made from roselle (Hibiscus sabdariffa L.) flour
and chitosan
Authors: Kusnadi  , Purgiyanti  , Kumoro A.C. , Legowo A.M. , Putra O.N.
Published: October 2024

Biscuits made from roselle calyces and chitosan can be used as food ingredients to
complement food needs and are nutritious for health. Roselle calyces contain
anthocyanins, which have anti-hypercholesterolemic properties. Chitosan was also able to
reduce fat levels in plasma and the liver, thereby reducing cholesterol levels. This study
aimed to analyze the total anthocyanin content, determine the optimal formula, evaluate
sensory acceptance, and test the anti-hypercholesterolemic of biscuits containing
anthocyanins made from roselle (Hibiscus sabdariffa L.) flour and chitosan. The study
used a completely randomized design with four different proportions of the main
ingredients used to make biscuits containing roselle flour and chitosan, respectively; F0/
control negative (0:0)%; F1(4.5:0.5)%; F2(4:1)%; and F3(3.5:1.5)% and positive control
(Simvastatin drug). The findings revealed that the analysis of the differential pH method
on the total anthocyanin content of the four biscuit formulas showed a significant
difference (P<0.05). F3 with roselle 3.5% and chitosan 1.5% showed anthocyanin content
of 236.45±0.03 mg/kg higher than the others. Likewise, the evaluation of consumer
acceptance shows that F3 was better in assessing taste, texture, and overall compared to
F1 and F2. The in vivo analysis of the effectiveness of biscuits in lowering serum
cholesterol after consuming biscuit samples for twenty-one days showed that there was a
significant decrease in cholesterol levels with a decrease in total cholesterol and LDL by
33.72±1.39% and 35.87±2.29%, respectively in Formula 3 and followed by a decrease in
Formula 2 total cholesterol (30.34±1.79%) and LDL (27.31±2.60%).
Kurumsal Yönetim Algılarının Özel Hastanelerin Rekabet Düzeylerine Etkisi –Ankara İli Örneği (The Effect of Corporate Governance Perceptions on the Competitive Levels of Private Hospitals –The Case of Ankara Province)
Authors: Baş Önder , Sayar Zafer
Published: October 2024

Kurumsal yönetim özellikle son yıllarda hızlı bir yayılım göstermiş ve işletmeler için dikkate değer bir noktaya ulaşmıştır.Özellikle dünyada ki büyük işletmelerin finansal raporlarında görülen hatalar ve yanlış bilgiler,kurumsal yönetim konusunda ki dikkatlerinartmasına sebep olmuştur.Rekabet içinde olan özel hastaneler için farklı stratejiler geliştirmek birincil öncelikler arasına girmiştir.Sağlık sektöründe kurumsal yönetim, hastaneler için bir başarı ve güven oluşturmaktadır. Bu çalışmanın amacı,kurumsal yönetim konusundaki yönetici algılarının,özel hastanelerinyaşadıkları rekabet düzeylerineve stratejilerineetkisini belirlemekve kurumsal yönetim konusunda farkındalığın artmasına katkı sunmaktır. Çalışma ile Ankara da kurumsal yönetime sahip hastanelerin yöneticileri ile anket yapılmış ve görüşleri alınmıştır. Katılımcılara 20 soruluk bir anket uygulanmış ve sonuçlar analiz edilmiştir. Araştırma bulgularına göre, kurumsal yönetimin rekabeti olumlu şekilde etkilediği görülmüştür.Bu sonuç aynı zamanda sağlık sektöründe hizmet üreten özel hastanelerin rekabette etkin olması için kurumsal yönetime sahip olması ve kurumsal yönetimin güçlendirilmesi gerektiğini ortaya koymaktadır.
Sağlık Çalışanlarının Stresle Başa Çıkma Yöntemlerinin, Yaşam Doyumu ve Mutluluk Düzeyleri Üzerindeki Etkisi: Kırıkkale Örneği (The Effect of Health Workers Coping Methods With Stress on Their Life Satisfaction and Happiness Levels: Kırıkkale Example)
Authors: Akca Nesrin , Kar Ahmet , Erice Ezgi , Even Şengül
Published: October 2024

Bu çalışma; sağlık çalışanlarının stresle başa çıkma yöntemleri, yaşam doyumları ve mutluluk düzeyleri arasındaki ilişki ve birbirlerini etkileme düzeylerinin incelenmesi amacıyla planlanan kesitsel tipte tanımlayıcı nitelikte tasarlanmış nicel bir araştırmadır. Araştırmanın çalışma grubunu Kırıkkale Üniversitesi Tıp Fakültesi Hastanesi’nde görev yapan 258 sağlık çalışanı oluşturmuştur. Veri toplamada; “demografik ve bireysel bilgi formu”, “Yaşam Doyumu Ölçeği”, “Stresle Başa Çıkma Ölçeği” ve “Mutluluk Ölçeği” kullanılmıştır. Verilerin analizinde; tanımlayıcı istatistikler, bağımsız örneklem t testi, Tek Yönlü Varyans Analizi (ANOVA), post-hoc testlerden Bonferroni analizi ve Pearson Korelasyon analizinden yararlanılmıştır.Stresle başa çıkma durumunun mutluluk üzerindeki etkisinde, yaşam doyumunun aracılık etkisi ve değişkenler arasındaki doğrudan ve dolaylı etkiler SPSS process makrosu ile Model 4 kullanılarak gerçekleştirilmiştir.Araştırmasonuçlarına göre; stresle başa çıkma durumu, yaşam doyumunu pozitif yönde etkilemektedir. Stresle başa çıkma durumunda meydana gelen artış, yaşam doyumunu da artırmaktadır. Stresle başa çıkma durumunun mutluluk üzerindeki etkisinde yaşam doyumunun kısmi aracılık etkisi olduğu bulunmuştur.Sağlık çalışanlarının psikolojik, ruhsal ve sosyal yönden ihtiyaçları karşılanmalı, yaşam doyumları ve mutluluk düzeyleri olabilecek en yüksek seviyede tutulmalı ve stres seviyeleri olabildiğince düşürülerek daha verimli çalışmaları sağlanmalıdır.
THE WAY OF BREAD – INTERDISCIPLINARY LESSON FOR FORTH GRADE
Authors:   First Primary School ‘St. Cyril and St. Methodius’, Gotse Delchev, Moskova Stoyna , Pashalieva Teodora ,   First Primary School ‘St. Cyril and St. Methodius’, Gotse Delchev, Pavlevichina Nina ,   First Primary School ‘St. Cyril and St. Methodius’, Gotse Delchev
Published: October 2024

‘The Way of Bread’ is an interdisciplinary lesson that combines knowledge of Bulgarian language and literature, mathematics, man and society, man and nature, technology and entrepreneurship, fine arts. The aim of this lesson is to make students understand the importance of bread in human life. It teaches respect for history, work, traditions and customs. Through a pre-prepared presentation, the teacher gives a motivated and emotional introduction to the topic. In the worksheet, he skillfully uses the students’ knowledge of the diff erent subjects to highlight the relevance of the topic in time. The teacher of history and civilizations in the junior secondary stage presents with historical facts the appearance of the first bread. He sets tasks of different nature to the students. The teacher focused on the ritual kneading of the bread, telling about the tradition and showing the kneading process. He makes reference to the future by using the latest and modern information technology. Through artificial intelligence, it shows what the bread of the future will look like. GPT chat presents a recipe for a magical bread. Makes a comparison between the real and the virtual. The theoretical part of the lesson is followed by a practical part. Students follow the different stages of bread making by visiting a local bakery. They learn about the baker’s profession, the technology and the bread’s journey to our table. They are taught respect for every job and profession.
INTERDISCIPLINARY DAYS AT SCHOOL – AN INNOVATIVE APPROACH TO DEVELOP SOCIAL AND CULTURAL SKILLS OF STUDENTS
Authors:   ‘Tsanko Tserkovski’ Elementary School, Sredishte village, Stoyanova Sibel , Ivanov Ivelin ,   ‘Tsanko Tserkovski’ Elementary School, Sredishte village
Published: October 2024

Conducting interdisciplinary days: students are involved in activities that develop their oral and written culture, enrich their active vocabulary and broaden their cultural horizons. Through the activities, knowledge from diff erent scientific fields is integrated in order to solve a common problem. The interdisciplinary day includes activities in classes for advanced training, technical subjects, field trips, work in classes for interests, general school activity for presenting the projects realized by the students. Conditions are created for motivated practical application of the acquired knowledge and skills acquired in individual subjects in new situations. Competence in the various academic disciplines is increased, creative search and cognitive activity are provoked.
A STEAM ADVENTURE. TRANSFORMING TRASH INTO TREASURE
Authors:   First primary school ‘St. Cyril and St. Methodius’ Gotse Delchev, Dineva Nadka
Published: October 2024

Modern technology and mass information demand more creativity, innovation and critical thinking. Well-rounded individuals are once again in demand, and the education system must respond to the trends. Early interdisciplinary education is imperative. It helps students understand the connections between science, technology and art, and to work as a team. Integrating science, technology, engineering, art and math in the environmental projects into education provides students with the knowledge, skills, and mindset needed to be stewards of the environment. This type of learning stimulates students to be discoverers, as well as to make a connection between theoretical knowledge and its practical real application.
Detection of airborne wild waterbird-derived DNA demonstrates potential for transmission of avian influenza virus via air inlets into poultry houses, the Netherlands, 2021 to 2022
Authors: Bossers Alex , de Rooij Myrna MT , van Schothorst Isabella , Velkers Francisca C , Smit Lidwien AM
Published: October 2024

Background

Outbreaks of highly pathogenic avian influenza (HPAI) on poultry farms and in wild birds worldwide persists despite intensified control measures. It causes unprecedented mortality in bird populations and is increasingly affecting mammalian species. Better understanding of HPAI introduction pathways into farms are needed for targeted disease prevention and control. The relevance of airborne transmission has been suggested but research involving air sampling is limited and unequivocal evidence on transmission routes is lacking.

Aim

We aimed to investigate whether HPAI virus from wild birds can enter poultry houses through air inlets by characterising host materials through eukaryote DNA sequencing.

Methods

We collected particulate matter samples in and around three HPAI-affected poultry farms which were cleared and decontaminated before sampling. Indoor measurements (n = 61) were taken directly in the airflow entering through air inlets, while outdoor air samples (n = 60) were collected around the poultry house. Positive controls were obtained from a bird rehabilitation shelter. We performed metabarcoding on environmental DNA by deep sequencing 18S rRNA gene amplicons.

Results

We detected waterbird DNA in air inside all three, and outside of two, poultry farms. Sequences annotated at species level included swans and tufted ducks. Waterbird DNA was present in all indoor and outdoor air samples from the bird shelter.

Conclusion

Airborne matter derived from contaminated wild birds can potentially introduce HPAI virus to poultry houses through air inlets. The eDNA metabarcoding could assess breaches in biosecurity for HPAI virus and other pathogens potentially transmitted through air via detection of their hosts.
Almost ∗-Ricci Soliton on α-paraSasakian Manifold
Authors: Sood Kanika , Srivastava Khushbu , Srivastava Sachin Kumar , Khan Mohammad Nazrul Islam
Published: October 2024

It has been noted that if the ∗-Ricci tensor used to define ∗-Ricci soliton is a constant multiple of the metric tensor g(ei,ej), for all ei, ej orthogonal to characteristic vector field ξ, then the manifold is ∗-Einstein manifold. The metric associated with ∗-Einstein manifold is ∗-Einstein metric, and the ∗-Ricci soliton is its generalization. In this paper we study an almost ∗-Ricci soliton (g, W, λ) and an almost gradient ∗-Ricci soliton (g, grad (ρ), λ) by means of mathematical operators on (2m+1)-dimensional α-paraSasakian manifold S2m+1.
Building a Space Shooter Game: Utilizing Scratch for an Engaging Action Game
Authors: Juanda Juanda , Zikrillah Zikrillah , Nasrullah Nasrullah
Published: October 2024

The rapid advancement of computer technology in the field of animation is marked by the emergence of various programming applications that simplify the creation of animations, one of which is Scratch. Games have become a popular form of entertainment across various audiences, including the Space Shooter game, which is designed to provide an exciting and entertaining action experience. In this game, players are challenged to control a spaceship and fight enemies that appear from the top of the screen, while avoiding enemy attacks and shooting them to earn points. The objective of the Space Shooter game development is to create a game that combines attractive graphics, addictive gameplay mechanics, and increasing difficulty levels as the player progresses. Additionally, the game aims to test the player's endurance in surviving as long as possible while collecting the highest score. The development of this game is expected to offer a fun and challenging gaming experience, while also improving players' decision-making skills and reflexes during gameplay.
The Use of Brown's Double Exponential Smoothing Method to Predict Harvest Yields in Horticultural Crops
Authors: Mutiara Mutiara , Fuadi Wahyu , Maryana Maryana
Published: October 2024

Agriculture stands as a pivotal sub-sector within the economy of North Aceh. Among its primary commodities are horticultural crops, encompassing the cultivation of vegetables, fruits, medicinal plants, and ornamental flora. In endeavors to boost agricultural productivity and efficiency, the utilization of harvest prediction methodologies has grown increasingly indispensable. This study relies on historical harvest data spanning from 2017 to 2022 to forecast crops such as leafy greens, fruits, and medicinal plants. The selected plants for prediction include spinach, water spinach, cucumber, banana, durian, rambutan, ginger, lesser galangal, and turmeric. Data analysis employs Brown's double exponential smoothing method, selecting the α (alpha) parameter that minimizes the Mean Absolute Percentage Error (MAPE) for accurate forecasting. Spinach is anticipated to yield 1239.9508 quintals, with an α (alpha) parameter of 0.9 and a MAPE of 38.46%. Water spinach is forecasted to yield 2069.75 quintals, with an α (alpha) parameter of 0.5 and a MAPE of 18.14%. Cucumber is projected to yield 1023.22432 quintals, with an α (alpha) parameter of 0.4 and a MAPE of 31.51%. Consequently, the highest projected yield is for water spinach at 2069,75 quintals.
Web-Based Expert System Application for Early Diagnosis of HIV/AIDS Using the Naive Bayes Method
Authors: Aisah Sri Purwani , Adek Rizal Tjut , Yunizar Zara
Published: October 2024

AIDS is a progressive decrease in the immune system so that opportunistic infections can appear and end in death, therefore the author created an early diagnosis system for HIV/AIDS using the website-based Naïve Bayes algorithm. Naïve Bayes is a simple probability classification that can calculate all possibilities by combining a number of combinations and frequencies of a value from the database obtained.the results of the research obtainedThe naïve Bayes algorithm can be implemented for early diagnosis of HIV/AIDS by means that the existing HIV/AIDS symptom data is adjusted to the patient's symptom data processed using the naïve Bayes algorithm and then it is concluded what the symptoms are and What is the solution.
De las Armas al Deporte: El Papel del Deporte Adaptado en la Evaluación de los Niveles de Actividad Física y Discapacidad de Militares Víctimas del Conflicto Armado Colombiano
Authors: Alfonso Borda Jose Luis , Beltran Peña Nubia Yaneth
Published: October 2024

En Colombia, durante décadas, se vivió un conflicto armado interno con la guerrilla de las FARC-EP. En el año 2016 se firmó un acuerdo final de paz entre ambas partes. Durante este conflicto hubo víctimas de las fuerzas armadas, las cuales sufrieron heridas graves en combate, generándoles una discapacidad. El objetivo del estudio fue describir el impacto del deporte adaptado en los niveles de actividad física, discapacidad y calidad de vida de militares. Es un estudio descriptivo prospectivo con enfoque cuantitativo. Participantes: 31 hombres, militares del Ministerio de Defensa de Colombia, con una discapacidad física, distribuidos en las disciplinas deportivas adaptadas: voleibol sentado, esgrima en silla de ruedas, para powerlifting, taekwondo adaptado, para triatlón, tenis de mesa adaptado, para cycling, para natación y atletismo. Método: Se aplicaron dos cuestionarios para conocer el estado físico y deportivo de los participantes: la Escala de Actividad Física PASIPD y el Cuestionario WHODAS 2.0. Los resultados demostraron que la actividad física y el deporte adaptado son herramientas beneficiosas para los militares con una discapacidad física, mejorando las dimensiones de salud física, mental, social y proporcionando la oportunidad de vincularse con otros en circunstancias semejantes, además de competir deportivamente. Se concluye que es perentorio trazar políticas públicas, programas y mecanismos institucionales de cara a los desafíos propios de una nación en el postconflicto, que procuren el desarrollo humano sustentable, usando como herramienta la actividad física y el deporte.
DIVINE STITCH: EMBELLISHING HOME FURNISHING THROUGH GODNA ART
Authors: Singh Shweta , Juneja Shalini
Published: October 2024

Old structures and heritage symbolise the culture of a place, giving it a unique identity. In Chhattisgarh, the Gond tribe traditionally practised godna, a form of tattoo art with deep cultural significance. Each motif in Godna holds a special meaning, often tied to religious beliefs and healing properties, making these tattoos highly valued. However, the traditional art of Godna is gradually fading away in modern times. By studying tribal art applied by the original designs of Godna, the study will indicate the value of Home Furnishing Articles. The furnishing articles will improve the design and quality of the indoor articles. The research paper will indicate how home furnishing items, explore and influence design trends, crossover designs, and public perception. By analysing principles of design, the paper explores that home furnishing items can incorporate elements of Godna art while meeting specific performance and aesthetic requirements. Ultimately, this research aims to contribute to the enrichment and innovation of Godna art motifs, thereby elevating the cultural value of related products.
Teologia e direitos humanos
Authors: LIMA ADRIANO SOUSA , MACHADO DINAMARA PEREIRA
Published: October 2024

Resultado da pesquisa de teólogos e teólogas, o livro “Teologia e direitos humanos: diálogos interdisciplinares”, apresenta nove capítulos que procuram, em diálogo com outras disciplinas, ampliar a visão epistemológica da teologia contribuindo, assim, por processos do conhecimento articulados através do diálogo.