bluuebunny/crossref_metadata_2025 huggingface dataset:
Metric Mean Dimension and Mean Hausdorff Dimension Varying the Metric
Authors: Muentes J. , Becker A. J. , Baraviera A. T. , Scopel É.
Published: August 2024

Let $$f:\mathbb {M}\rightarrow \mathbb {M}$$

f
:
M
→
M

be a continuous map on a compact metric space $$\mathbb {M}$$
M
equipped with a fixed metric d, and let $$\tau $$
τ
be the topology on $$\mathbb {M}$$
M
induced by d. We denote by $$\mathbb {M}(\tau )$$

M
(
τ
)

the set consisting of all metrics on $$\mathbb {M}$$
M
that are equivalent to d. Let $$ \text {mdim}_{\text {M}}(\mathbb {M},d, f)$$

mdim
M

(
M
,
d
,
f
)

and $$ \text {mdim}_{\text {H}} (\mathbb {M},d, f)$$

mdim
H

(
M
,
d
,
f
)

be, respectively, the metric mean dimension and mean Hausdorff dimension of f. First, we will establish some fundamental properties of the mean Hausdorff dimension. Furthermore, it is important to note that $$ \text {mdim}_{\text {M}}(\mathbb {M},d, f)$$

mdim
M

(
M
,
d
,
f
)

and $$ \text {mdim}_{\text {H}} (\mathbb {M},d, f)$$

mdim
H

(
M
,
d
,
f
)

depend on the metric d chosen for $$\mathbb {M}$$
M
. In this work, we will prove that, for a fixed dynamical system $$f:\mathbb {M}\rightarrow \mathbb {M}$$

f
:
M
→
M

, the functions $$\text {mdim}_{\text {M}} (\mathbb {M}, f):\mathbb {M}(\tau )\rightarrow \mathbb {R}\cup \{\infty \}$$

mdim
M

(
M
,
f
)

:
M

(
τ
)

→
R
∪

{
∞
}

and $$ \text {mdim}_{\text {H}}(\mathbb {M}, f): \mathbb {M}(\tau )\rightarrow \mathbb {R}\cup \{\infty \}$$

mdim
H

(
M
,
f
)

:
M

(
τ
)

→
R
∪

{
∞
}

are not continuous, where $$ \text {mdim}_{\text {M}}(\mathbb {M}, f) (\rho )= \text {mdim}_{\text {M}} (\mathbb {M},\rho , f)$$

mdim
M

(
M
,
f
)

(
ρ
)

=

mdim
M

(
M
,
ρ
,
f
)

and $$ \text {mdim}_{\text {H}}(\mathbb {M}, f) (\rho )= \text {mdim}_{\text {H}} (\mathbb {M},\rho , f)$$

mdim
H

(
M
,
f
)

(
ρ
)

=

mdim
H

(
M
,
ρ
,
f
)

for any $$\rho \in \mathbb {M}(\tau )$$

ρ
∈
M
(
τ
)

. Furthermore, we will present examples of certain classes of metrics for which the metric mean dimension is a continuous function.
Deciphering the needs of patients with hereditary breast and ovarian Cancer in the Process of Genetic Counseling to Inform the Development of a Mobile Support App: a qualitative study in Germany
Authors: Ammon Nils , Reichert Chiara , Kupka Thomas , Oeltze-Jafra Steffen , Bergmann Anke Katharina , Schlegelberger Brigitte , Wolff Dominik , Vajen Beate
Published: August 2024

Patients with hereditary breast and ovarian cancer (HBOC) are not only concerned about their own health but also about that of their children, grandchildren, and other relatives. Therefore, they have specific needs for information and support. During genetic counseling guidance is provided to HBOC patients and other individuals who may be at risk for familial cancer. The purpose of the study was to identify the needs of HBOC patients during the genetic counseling process that could be addressed by digital solutions. Nine semi-structured qualitative interviews were conducted. Overall, the patients appreciated the personal contact with human geneticists as an especially positive factor in the genetic counseling process. However, patients noted the following needs (1) support in the time following genetic counseling, (2) support before genetic counseling by collecting own and familial medical information, (3) Need for contact options to support services, (4) Need for patient-friendly medical information, (5) Wish for administration-related components in a support app. The results will inform the development of a patient-centered mobile support app.
A method for identifying exceedances of permissible NOX air pollutants by car traffic in a polish city
Authors: Kwiecień J. , Olenkowicz-Trempała P.
Published: August 2024

Urban traffic causes air pollution in the city, contributing to respiratory diseases. For this reason, the article aimed to identify places in the street network where nitrogen oxide (NOX) pollution exceeds the permissible value, i.e., 30 µg/m3, by Directive 2008/50/EC of the European Parliament. The research was conducted during the COVID-19 pandemic during the period of the most significant restrictions in 2020, with most restrictions lifted in 2021. The article presents a method for identifying points with concentrations of air pollutants exceeding the standards in the example of a large Polish city. The research results allowed for precisely identifying places in the city’s street network with the worst air quality parameters. Hence, the article aimed to identify areas with the worst air quality parameters in terms of NOX emissions, which will enable actions that may reduce the pollutants examined. The research used the ADMS atmospheric dispersion modeling program, a road traffic database obtained from the Sydney Cooperative Adaptive Traffic System, and Geographic Information System programs. The number of identified points with NOX pollution exceeding the permissible EU standard in 2020 (during the Covid-19 pandemic) was in the range of 30.00–79.42 µg/m3 was 771, while after the pandemic it ranged from 30.06 to 97, 91 µg/m3 428. The proposed method for precise point identification of NOX pollutants caused by road traffic is a universal tool for detecting and analyzing pollutants in urban agglomerations.
Sustainable construction: the use of cork material in the building industry
Authors: Yadav Madhura , Singhal Ishika
Published: August 2024

In the ongoing quest for sustainable construction practices, the exploration of innovative materials is paramount, and cork has emerged as a remarkable eco-friendly building material with vast untapped potential. Cork, harvested from the bark of cork oak trees without harming them, possesses a unique combination of qualities that make it an ideal candidate for environmentally conscious construction. Cork is exceptionally renewable and biodegradable. What makes cork even more promising is its compatibility with various existing construction materials, including cement, plastic, and plywood. By integrating cork with these materials, we can improve their structural integrity, thermal performance, and acoustic insulation, while reducing their environmental impact. By harnessing the potential of cork and seamlessly merging its exceptional performance with a planet-conscious approach, the construction industry can significantly reduce its ecological footprint. Cork emerges as a compelling contender in shaping a greener, more resilient construction landscape, offering a sustainable alternative that aligns with our growing commitment to environmentally responsible building practices. This eco-friendly material not only benefits the environment but also enhances the overall quality and sustainability of our built environment.
Feasibility study on conversion of biowaste of lemon peel into carbon electrode for supercapacitor using ZnCl2 as an activating agent
Authors: Michael M. S. , Surya K.
Published: August 2024

Here, we describe the analysis of the capacitive performance of activated carbon materials derived from the biowaste of lemon. Lemon peel discarded by restaurants after juice extraction is carbonized at 400 0C followed by chemical activation using ZnCl2. The porosity of carbon materials is tailored by varying activation conditions, such as the mass ratio of carbonized lemon peel and ZnCl2, duration of heating, and temperature. The Brunauer–Emmett– Teller (BET) surface area and pore volume of carbon materials prepared at different activating conditions range from 1380 to 2120 m2g−1 and 0.38 to 0.69 cm3 g−1 respectively. The derived carbon materials are amorphous indicated by the broad peaks in the XRD pattern as well as disordered structure of the carbon materials is revealed by the Raman spectroscopic analysis. The systematic analysis of capacitive performance of activated carbons by employing electrochemical techniques like Cyclic Voltammetry (CV), Galvanostatic charge/Discharge (GCD) cycles, and electrochemical impedance spectroscopy (EIS) in acidic (H2SO4) and alkaline (KOH) media indicates that optimum condition for activation of lemon peel is 600 °C for 60 min with 1:1 mass ratio of carbonized lemon peel and ZnCl2. The superior performance of (ALP-600) is attributed to its high surface area and well-connected hierarchical porous structure. The tiny hump at ~ 0.2 V in CV might be due to the pseudocapacitive nature of oxygen functional groups indicated by FTIR. ALP-600 exhibits the highest specific capacitance of 180 Fg−1 and retains 99.7% of its initial capacitance after 5000 cycles in the acidic electrolyte. The maximum capacitance achieved with ALP-600 symmetric cell in CR2032 coin cell configuration is 0.90F.
An accurate identification and spatial characterization method for the development degree of preferential flow paths in water-flooded reservoir
Authors: Fu Hongtao , Song Kaoping , Ma Zilin , Zhao Yu , Liang Lihao , Guo Hu
Published: August 2024

Water flooding is one of the most important methods for oil field development, It accounts for more then 70% of China's crude oil production. However, in the progress of water flooding, preferential flow paths often formed between oil and water wells, which seriously restricts production rate. How to effectively identify the preferential flow paths has become the key to improving the effect of water flooding. In this paper, to solve the problem of difficult identification of preferential flow paths in reservoirs, through the change of core seepage law with high pore volume water flooding experiment, parameters such as multiple of water flux, change value of permeability, and water saturation were selected for analysis. The weight coefficient for each parameter was determined by the variation coefficient method of objective weight. Subsequently, a comprehensive reservoir identification index was obtained by weighting each parameter, which was used to describe the development degree of the preferential flow paths. Finally, quantitative criteria of preferential flow paths were given. The spatial characterization of preferential flow paths was realized by post processing of the Eclipse software. The new method for identifying preferential flow paths fully considers the changes in physical properties and fluid mobility of water-flooded reservoirs. The results of the new applied to a typical water-flooded reservoir in the Bohai Bay Basin show that the preferential flow paths calculated by the new method were highly consistent with the judgment results of tracers. It can accurately and quickly identify the preferential flow paths. This study provides a scientific basis for adjusting measures of water-flooded reservoirs to further enhance oil recovery. Moreover, the new method holds broader prospects for application in the field of porous media transport.
Shared Micro-mobility Market Disturbances: the Polish Bike Sharing Market in Light of Z-score Analysis
Authors: Bieliński Tomasz , Ważna Agnieszka B. , Antonowicz Paweł
Published: August 2024

Urban transportation has changed dramatically in the recent years through the large scale implementation of shared micro-mobility services, especially bike sharing systems (BSS) and electric scooter sharing (ESS). The COVID-19 pandemic brought further changes and uncertainty to this turbulent business environment. In 2020, the major BSS operator in Poland filed for bankruptcy claiming that its problems arise from the COVID-19 pandemic. Market reports and media speculated that BSS business, despite being publicly financed, and considered to be a of part of public transportation system, could be unsustainable in face of the competition from ESS. We used Z‑score analysis to investigate if bike sharing systems operators’ problems began before or during the COVID-19 pandemic and large scale development of ESS. Our study focuses on the Nextbike company, which held a dominant stake in the Polish BSS market. It also covers two other major Polish operators and includes a German operator for comparative analysis. To complement the quantitative findings from z‑score analysis, we have also interviewed representatives of major stakeholders, which deepened our understanding of BSS problems. The results of our research indicate that although the market was affected by the COVID-19 pandemic and growing scooter-sharing competition, the problems of the largest BSS operator were specific to this company, and the entire market was not under the risk of failure.
A user guide of CART and random forests with applications in FinTech and InsurTech
Authors: Chen Yongzhao , Cheung Ka Chun , Sun Ross Zhengyao , Yam Sheung Chi Phillip
Published: August 2024

In the realm of financial data analytics, machine learning techniques, particularly classification and regression trees (CARTs) and random forests, have shown remarkable efficiency. This article serves as a user guide for these methods, with an emphasis on their applicability and effectiveness in analyzing datasets in FinTech and InsurTech. In particular, we present several numerical examples and empirical studies, and demonstrate their superiority in handling data with a variety of input features, offering insights into their potential applications in the industries.
Widespread service fragmentation for patients and families with tuberous sclerosis complex (TSC) in the Republic of Ireland
Authors: Vasseghi M. , Behan C. , Connolly A. , Cunningham D. , Dempsey E. , Flynn C. , Galvin M. , Griffin G. , Moloney P. , Murphy M. , Owen Y. , O’Malley S. , O’Rourke G. , O’Sullivan O. , Doherty C. P.
Published: August 2024

Background

Tuberous sclerosis complex (TSC) is a rare approximate 1:6000 birth incidence, a genetic disease with a wide variability of physical and neuropsychiatric symptoms. Patients require lifelong care from multiple healthcare specialities, for which International and United Kingdom (UK) TSC consensus recommendations exist. Personalised care delivered by a centralised coordinated team of TSC experts is recommended. There is no such service for the estimated 600 TSC patients in the Republic of Ireland (ROI) and there is a paucity of information regarding the healthcare of this group.

Purpose

Evaluate the baseline care of patients with TSC attending epilepsy services in the Republic of Ireland (ROI) against UK TSC consensus recommendations.

Methods

Patients with a diagnosis of TSC attending 12 adult and paediatric epilepsy centres in the ROI were identified. Clinical audits measured the baseline care of a subset of these patients against UK, TSC clinical recommendations. Data was anonymised and analysed at Trinity College Dublin.

Results

One hundred thirty-five TSC patients attending twelve epilepsy centres were identified. Adults (n = 67) paediatric (n = 68). The care of 83 patients was audited (n = 63 ≥ 18 years) and (n = 20 < 18 years). Many baseline tests were completed, however, they required intra or interhospital referral. Care appears fragmented and there was no evidence of formal disease surveillance plans.

Conclusions

The number of TSC patients attending epilepsy services is lower than expected (n = 135). Specialist services and treatments for TSC are available through informal referral pathways. Although UK, TSC consensus baseline recommendations are roughly adhered to, care is fragmented. Increased coordination of care could benefit disease management.
The role of CEUS as problem-solving technique when abdominal CT or MRI are inconclusive
Authors: Blandino Antonino Andrea , Giangrande Davide , Cannella Roberto , Bartolotta Tommaso Vincenzo
Published: August 2024

Purpose

To evaluate the role of CEUS in the characterization of abdominal lesions compared to CT and MRI and whether it could be “problem-solving” when CT and/or MRI are inconclusive or contraindicated.

Methods

A retrospective study was conducted on 39 patients (22 males; mean age: 64 years) with one or more abdominal focal lesions (total: 41; mean diameter: 2.9 cm) who underwent CEUS, had already undergone CT/MRI without a definitive diagnosis or had not undergone them due to contraindications. The frequency, out of the total lesions included, in which CEUS was problem-solving, confirmatory or inconclusive was evaluated.

Results

CEUS proved to be problem-solving for 20/41 (48.8%) lesions, confirmatory for 17/41 (41.5%) lesions and inconclusive for 4/41 (9.7%) lesions. Including problem-solving and confirmatory diagnosis, CEUS correctly identified 24/27 (88.9%) liver lesions, 11/11 (100%) kidney lesions, a gallbladder and a pancreatic lesion, while it did not provide useful information for 4/41 (9.7%) lesions, specifically three liver lesions and a testicular one.

Conclusions

CEUS is a promising technique when CT and/or MRI are inconclusive or contraindicated and to increase the radiologist’s diagnostic confidence.
The role of the adenylate kinase 5 gene in various diseases and cancer
Authors: Siddiqui M. Sarim , Shahi Mehdi H. , Castresana Javier S.
Published: August 2024

Adenylate kinases (AKs) are important enzymes involved in cellular energy metabolism. Among AKs, AK5 (adenylate kinase 5), a cytosolic protein, is emerging as a significant contributor to various diseases and cellular processes. This comprehensive review integrates findings from various research groups on AK5 since its discovery, shedding light on its multifaceted roles in nucleotide metabolism, energy regulation, and cellular differentiation. We investigate its implications in a spectrum of diseases, including autoimmune encephalitis, epilepsy, neurodegenerative disorders such as Alzheimer’s and Parkinson’s, diabetes, lower extremity arterial disease, celiac disease, and various cancers. Notably, AK5’s expression levels and methylation status have been associated with cancer progression and patient outcomes, indicating its potential as a prognostic indicator. Furthermore, AK5 is implicated in regulating cellular processes in breast cancer, gastric cancer, colorectal carcinoma, prostate cancer, and colon adenocarcinoma, suggesting its relevance across different cancer types. However, a limitation lies in the need for more robust clinical validation and a deeper understanding of AK5’s precise mechanisms in disease pathogenesis, despite its association with various pathophysiological conditions. Nonetheless, AK5 holds promise as a therapeutic target, with emerging evidence suggesting its potential in therapy development.
Autonomy Through Allotment: Political Strategies of the Ottawa Tribe in Indian Territory, 1870–1892
Authors: Dry David
Published: August 2024

The late nineteenth-century policy of allotting tribal lands into individually owned tracts is appropriately interpreted as a destructive federal effort to expropriate Native land and eliminate tribal identities. The Ottawa Tribe in Indian Territory, however, had divergent objectives in supporting allotment. This article argues the Ottawa advocated for allotment and U.S. citizenship to escape intrusive federal control over their lands and resources. Although they embraced policies aimed at eliminating tribal existence, the Ottawa rejected the intentions behind those policies, and instead, they drew on long-established community attributes of mobility and interconnection with outsiders to resituate their nation within American society. By centering Ottawa perspectives, this article disrupts progressive narratives that denote the pursuit of U.S. citizenship as an effort to secure equal inclusion. It underscores U.S. citizenship and allotment as tools of settler colonial domination and demonstrates how the Ottawa subversively deployed U.S. citizenship and private property rights to combat colonial administration and maintain tribal sovereignty. Examining a policy often glossed over as invariably imposed on Native nations, this article underscores the necessity of analyzing Native community dynamics and political strategies to understand the implementation and impact of allotment.
Probable Concretions Observed in the Shenandoah Formation of Jezero Crater, Mars and Comparison With Terrestrial Analogs
Authors: Kalucha H. , Broz A. , Randazzo N. , Aramendia J. , Madariaga J. M. , Garczynski B. , Lanza N. , Mandon L. , Fouchet T. , Catling D. C. , Fairén A. G. , Kivrak L. , Gasda P. J. , Núñez J. I. , Cloutis E. , Hand K. P. , Rice J. W. , Fischer W. W. , Maurice S. , Wiens R. C.
Published: August 2024

The Mars 2020 Perseverance Rover imaged diagenetic textural features in four separate sedimentary units in its exploration of the 25‐m‐thick Shenandoah formation at Jezero Crater, Mars, that we interpreted as probable concretions. These concretions were most abundant in the Hogwallow Flats member of the Shenandoah formation and were restricted to the light‐toned, platy, sulfur‐cemented bedrock at outcrop surfaces, whereas the finely laminated, darker toned, mottled and deformed strata lack concretions. The concretions also had a wide range of morphologies including concentric, oblate, urn, and spheroidal shaped forms that were not clustered, and ranged in size from ∼1 to 16 mm with a median of 2.65 mm. The elemental composition of the concretions compared to the bedrock had greater abundance of magnesium and calcium salts, silicates, and possibly hematite. We compared these Jezero Crater concretions to the geochemistry of concretions from previously published studies and from two new terrestrial analog sites (Gallup Formation, New Mexico and Torrey Pines, California). In addition, we measured organic carbon content of three terrestrial sedimentary analogs of increasing age that contain concretions (Torrey Pines (Pleistocene), Gallup Formation (∼89 Ma), and Moodies Group (∼3.2 Ga)). All measured concretions contained significant concentrations of organic carbon with the maximum organic carbon content (∼2 wt. % Total organic carbon) found in the Moodies Group concretions. Organic carbon abundances in terrestrial concretions was controlled more by the formation mechanism and relative timing of concretion development rather than deposit age. These findings suggested that concretions at Jezero Crater reflect local sites of enhanced biosignature preservation potential.
A wearable, rapidly manufacturable, stability-enhancing microneedle patch for closed-loop diabetes management
Authors: Liu Yiqun , Yang Li , Cui Yue
Published: August 2024

The development of a wearable, easy-to-fabricate, and stable intelligent minisystem is highly desired for the closed-loop management of diabetes. Conventional systems always suffer from large size, high cost, low stability, or complex fabrication. Here, we show for the first time a wearable, rapidly manufacturable, stability-enhancing microneedle patch for diabetes management. The patch consists of a graphene composite ink-printed sensor on hollow microneedles, a polyethylene glycol (PEG)-functionalized electroosmotic micropump integrated with the microneedles, and a printed circuit board for precise and intelligent control of the sensor and pump to detect interstitial glucose and deliver insulin through the hollow channels. Via synthesizing and printing the graphene composite ink, the sensor fabrication process is fast and the sensing electrodes are stable. The PEG functionalization enables the micropump a significantly higher stability in delivering insulin, extending its lifetime from days to weeks. The patch successfully demonstrated excellent blood glucose control in diabetic rats. This work may introduce a new paradigm for building new closed-loop systems and shows great promise for widespread use in patients with diabetes.
Recruitment of Cdc48 to chloroplasts by a UBX-domain protein in chloroplast-associated protein degradation
Authors: Li Na , Jarvis R. Paul
Published: August 2024

The translocon at the outer chloroplast membrane (TOC) is the gateway for chloroplast protein import and so is vital for photosynthetic establishment and plant growth. Chloroplast-associated protein degradation (CHLORAD) is a ubiquitin-dependent proteolytic system that regulates TOC. In CHLORAD, cytosolic Cdc48 provides motive force for the retrotranslocation of ubiquitinated TOC proteins to the cytosol but how Cdc48 is recruited is unknown. Here, we identify plant UBX-domain protein PUX10 as a component of the CHLORAD machinery. We show that PUX10 is an integral chloroplast outer membrane protein that projects UBX and ubiquitin-associated domains into the cytosol. It interacts with Cdc48 via its UBX domain, bringing it to the chloroplast surface, and with ubiquitinated TOC proteins via its ubiquitin-associated domain. Genetic analyses in Arabidopsis revealed a requirement for PUX10 during CHLORAD-mediated regulation of TOC function and plant development. Thus, PUX10 coordinates ubiquitination and retrotranslocation activities of CHLORAD to enable efficient TOC turnover.
Causal effect of video gaming on mental well-being in Japan 2020–2022
Authors: Egami Hiroyuki , Rahman Md. Shafiur , Yamamoto Tsuyoshi , Egami Chihiro , Wakabayashi Takahisa
Published: August 2024

The widespread use of video games has raised concerns about their potential negative impact on mental well-being. Nevertheless, the empirical evidence supporting this notion is largely based on correlational studies, warranting further investigation into the causal relationship. Here we identify the causal effect of video gaming on mental well-being in Japan (2020–2022) using game console lotteries as a natural experiment. Employing approaches designed for causal inference on survey data (n = 97,602), we found that game console ownership, along with increased game play, improved mental well-being. The console ownership reduced psychological distress and improved life satisfaction by 0.1–0.6 standard deviations. Furthermore, a causal forest machine learning algorithm revealed divergent impacts between different types of console, with one showing smaller benefits for adolescents and females while the other showed larger benefits for adolescents. These findings highlight the complex impact of digital media on mental well-being and the importance of considering differential screen time effects.
Bioinformatics analysis to disclose shared molecular mechanisms between type-2 diabetes and clear-cell renal-cell carcinoma, and therapeutic indications
Authors: Ahmmed Reaz , Hossen Md. Bayazid , Ajadee Alvira , Mahmud Sabkat , Ali Md. Ahad , Mollah Md. Manir Hossain , Reza Md. Selim , Islam Mohammad Amirul , Mollah Md. Nurul Haque
Published: August 2024

Type 2 diabetes (T2D) and Clear-cell renal cell carcinoma (ccRCC) are both complicated diseases which incidence rates gradually increasing. Population based studies show that severity of ccRCC might be associated with T2D. However, so far, no researcher yet investigated about the molecular mechanisms of their association. This study explored T2D and ccRCC causing shared key genes (sKGs) from multiple transcriptomics profiles to investigate their common pathogenetic processes and associated drug molecules. We identified 259 shared differentially expressed genes (sDEGs) that can separate both T2D and ccRCC patients from control samples. Local correlation analysis based on the expressions of sDEGs indicated significant association between T2D and ccRCC. Then ten sDEGs (CDC42, SCARB1, GOT2, CXCL8, FN1, IL1B, JUN, TLR2, TLR4, and VIM) were selected as the sKGs through the protein–protein interaction (PPI) network analysis. These sKGs were found significantly associated with different CpG sites of DNA methylation that might be the cause of ccRCC. The sKGs-set enrichment analysis with Gene Ontology (GO) terms and KEGG pathways revealed some crucial shared molecular functions, biological process, cellular components and KEGG pathways that might be associated with development of both T2D and ccRCC. The regulatory network analysis of sKGs identified six post-transcriptional regulators (hsa-mir-93-5p, hsa-mir-203a-3p, hsa-mir-204-5p, hsa-mir-335-5p, hsa-mir-26b-5p, and hsa-mir-1-3p) and five transcriptional regulators (YY1, FOXL1, FOXC1, NR2F1 and GATA2) of sKGs. Finally, sKGs-guided top-ranked three repurposable drug molecules (Digoxin, Imatinib, and Dovitinib) were recommended as the common treatment for both T2D and ccRCC by molecular docking and ADME/T analysis. Therefore, the results of this study may be useful for diagnosis and therapies of ccRCC patients who are also suffering from T2D.
Triazine herbicide prometryn alters epoxide hydrolase activity and increases cytochrome P450 metabolites in murine livers via lipidomic profiling
Authors: Sule Rasheed O. , Morisseau Christophe , Yang Jun , Hammock Bruce D. , Gomes Aldrin V.
Published: August 2024

Oxylipins are a group of bioactive fatty acid metabolites generated via enzymatic oxygenation. They are notably involved in inflammation, pain, vascular tone, hemostasis, thrombosis, immunity, and coagulation. Oxylipins have become the focus of therapeutic intervention since they are implicated in many conditions, such as nonalcoholic fatty liver disease, cardiovascular disease, and aging. The liver plays a crucial role in lipid metabolism and distribution throughout the organism. Long-term exposure to pesticides is suspected to contribute to hepatic carcinogenesis via notable disruption of lipid metabolism. Prometryn is a methylthio-s-triazine herbicide used to control the growth of annual broadleaf and grass weeds in many cultivated plants. The amounts of prometryn documented in the environment, mainly waters, soil and plants used for human and domestic consumption are significantly high. Previous research revealed that prometryn decreased liver development during zebrafish embryogenesis. To understand the mechanisms by which prometryn could induce hepatotoxicity, the effect of prometryn (185 mg/kg every 48 h for seven days) was investigated on hepatic and plasma oxylipin levels in mice. Using an unbiased LC–MS/MS-based lipidomics approach, prometryn was found to alter oxylipins metabolites that are mainly derived from cytochrome P450 (CYP) and lipoxygenase (LOX) in both mice liver and plasma. Lipidomic analysis revealed that the hepatotoxic effects of prometryn are associated with increased epoxide hydrolase (EH) products, increased sEH and mEH enzymatic activities, and induction of oxidative stress. Furthermore, 9-HODE and 13-HODE levels were significantly increased in prometryn treated mice liver, suggesting increased levels of oxidation products. Together, these results support that sEH may be an important component of pesticide-induced liver toxicity.
Temperature stability and enhanced transport properties by surface modifications of silica nanoparticle tracers for geo-reservoir exploration
Authors: Spitzmüller Laura , Berson Jonathan , Schimmel Thomas , Kohl Thomas , Nitschke Fabian
Published: August 2024

Tracer tests are an important tool for characterizing and monitoring subsurface reservoir properties. However, they are limited both because of the tracer molecules constraining factors such as irreversible adsorption, retention, and degradations, i.e. interaction processes of fluorophore molecule with surrounding media resulting in a large variation in transport properties. Elaborate tests utilizing more than one tracer to distinguish time or location of injection are complex and interpretation is ambiguous because each tracer interacts differently. In this study, we present an approach to increase tracer stability and enhance the transport uniformity of different tracers, thus making tests utilizing multiple tracers simpler and more feasible. We present this concept of tracer multiplicity by encapsulating an anionic, cationic or amphoteric fluorophore inside mesoporous silica nanoparticle carriers coated with a protective titania layer. Upon encapsulation, increased thermal resistance and drastically lowered sorption affinity towards quartz sand was detected in batch and flow-through experiments. An additional advantage of the presented nanoparticle tracers over molecular tracers is their modularity, which is demonstrated by surface modifications and application of additives that greatly reduce sorption and increase recovery rates in the flow experiments. With the here presented concept of tracer multiplicity, we introduce a new approach for colloidal tracer design that has the potential to expand and enhance measurable parameters, measurement accuracy and simplicity of analysis.
Feasibility study of UV intensity monitoring in water disinfection systems using reverse-biased LED photometers
Authors: Pousty D. , Gerchman Y. , Mamane H.
Published: August 2024

Common ultraviolet (UV) photodiodes or detectors for measuring the intensity of UV-light-emitting diodes (LEDs) in UV disinfection systems are costly.
Crevice corrosion behavior of a biodegradable Zn–Mn–Mg alloy in simulated body fluid
Authors: Wang Ting , Zhao An-Qi , Yan Yu , Wang Lu-Ning
Published: August 2024

A crevice corrosion protocol was designed to test the polarization curves of zinc alloys inside and outside the crevice, which can be applied to investigate the crevice corrosion of degradable materials.
Electronic, optical and charge transport properties of Zn–porphyrin–C60 MOFs: a combined periodic and cluster modeling
Authors: Granados-Tavera Kevin , Cárdenas-Jirón Gloria
Published: August 2024

MOFs@C60 exhibit low band gap energy and high electrical conductivity. The conductance and current increase with the incorporation of C60.
A novel method for the synthesis of MoSSe using an (Et4N)2[Mo3S4Se3Br6] complex as the sole precursor
Authors: Tran Dang B. , Le Ly T. , Nguyen Duc N. , Nguyen Quyen T. , Nga Ta Thi Thuy , Chou Wu-Ching , Luc Hoang H. , Dong Chung-Li , Tran Phong D.
Published: August 2024

Thermal decomposition of an (Et4N)2[Mo3S4Se3Br6] precursor under an inert atmosphere produces an alloy MoSSe material with a precise chemical composition.
O3 chemistry of 2,5-dimethylfuran: mechanism development
Authors: Illmann Niklas , Rösgen Vera
Published: August 2024

O3 chemistry of substituted furans might contribute to acidity in nighttime biomass burning plumes.
Unpaved road particulate matter emission rates and vehicle-induced transient plume characteristics
Authors: Kacer James , Altmaier Ralph , Cwiertny David M. , O'Shaughnessy Patrick T.
Published: August 2024

Particulate matter (PM) emitted from unpaved rural roads presents a potential inhalation hazard to people living and working near them.
A Pd-containing ionic liquid modified magnetic graphene oxide nanocomposite (Fe3O4/GO–IL–Pd) as a powerful catalyst for the reduction of nitrobenzenes
Authors: Dadvar Farkhondeh , Elhamifar Dawood
Published: August 2024

A novel palladium-containing ionic liquid-modified magnetic graphene oxide nanocomposite (Fe3O4/GO–IL–Pd) is synthesized and its catalytic performance is studied in the reduction of nitrobenzenes.
Unlocking the secrets of porous silicon formation: insights into magnesiothermic reduction mechanism using in situ powder X-ray diffraction studies
Authors: Martell Sarah A. , Yan Maximilian , Coridan Robert H. , Stone Kevin H. , Patwardhan Siddharth V. , Dasog Mita
Published: August 2024

The magnesiothermic reduction is an important reaction as it is a bulk method that produces porous Si for a wide range of applications directly from SiO2.
Harnessing J-aggregation for dual-color cellular imaging with chromenoquinoline-benzimidazole dyes
Authors: Shangguan Huimin , Teng Zixuan , Ren Xiaojie , Liu Xingjiang
Published: August 2024

Chromenoquinoline-benzimidazole (CQ-BI) complexes exhibit the unique capability of forming J-aggregates, enabling their utilization in dual-color cell imaging applications.
Computationally predicting the performance of gas sensor arrays for anomaly detection
Authors: Morris Paul , Simon Cory M.
Published: August 2024

To enable the computational design of gas sensor arrays for anomaly detection, we develop a method to computationally predict the performance of a proposed combination of recognition elements for a sensor array operating in anomaly detection mode.
Experimental and theoretical insights into benzene-1,4-dicarboxylic acid based Co-MOFs: an anodic material for expedient battery-supercapacitor hybrids
Authors: Khan Junaid , Ahmed Anique , Saleem Muhammad Imran , Al-Kahtani Abdullah A.
Published: August 2024

A Co-MOF assembled hybrid supercapacitor exhibits outstanding specific energy and power (60.07 W h kg−1 and 850 W kg−1) with 80.01% diffusive and 76.72% capacitive contribution at 3 and 100 mV s−1, respectively.
Intermittent control switch characteristics of triboelectric electric hybrid energy harvesting devices and power management circuits
Authors: Yu Xin , Cui Mingxing , Qi Wendong , Li Xinrui , Xing Yuhang , Lu Xiaolei , Yang Shitong , Zhao Jing , Jiang Changhong
Published: August 2024

A triboelectric electric hybrid energy harvesting device (HEH-TENG) and its power management circuit (HEH-PMC) with intermittent control switches were designed to harvest mechanical energy from rotation and vibration.
Electrocatalytic hydrogenation of the formyl group and heteroaromatic ring in furfural on activated carbon cloth-supported ruthenium
Authors: Kasad Meheryar R. , Jackson James E. , Saffron Christopher M.
Published: August 2024

Electrocatalytic transformation of furfural to tetrahydrofurfuryl alcohol on activated carbon cloth-supported ruthenium at mild conditions (≤ 50 °C under atmospheric pressure) using hydrogen equivalents produced in situ by water splitting.
Safe-and-sustainable-by-design roadmap: identifying research, competencies, and knowledge sharing needs
Authors: Apel Christina , Sudheshwar Akshat , Kümmerer Klaus , Nowack Bernd , Midander Klara , Strömberg Emma , Soeteman-Hernández Lya G.
Published: August 2024

Safe-and-Sustainable-by-Design (SSbD) roadmap for safe and sustainable chemicals, materials, products and process and a more sustainable future.
Mineralogical characteristics influence the structure and pozzolanic reactivity of thermally and mechano-chemically activated meta-kaolinites
Authors: Marsh Alastair T. M. , Brown Andy P. , Freeman Helen M. , Neumann Anke , Walkley Brant , Pendlowski Helen , Bernal Susan A.
Published: August 2024

Mechano-chemical activation enhances early age (<12 hours) pozzolanic reactivity of clays by transforming kaolinite to meta-kaolinite, reducing particle size, and potentially increasing the edge : basal surface area ratio of meta-kaolinite.
Insight into the interfacial reaction mechanism of FEC and NaF on Na for high performance sodium metal batteries
Authors: Chen Jinbiao , Liu Tianyong , Chu Mihai , Yu Kaichen , Xie Xintai , Lin Kaiji , Cheng Yifeng , Zhang Xin , Li Jie , Shi Zhicong
Published: August 2024

The presence of both NaF on the surface and FEC in electrolyte enables an effective SEI on Na anodes with high NaF content in the outer layer even after long term cycling, which secures the cycle life of sodium metal batteries.
Effective UV-protection and photovoltaic efficiency enhancement of polymer solar cells using diatom shells doped with Eu3+/Tb3+complexes
Authors: Li Tonghui , Shen Wenfei , Long Zaixin , Zhang Yanying , Wang Yao , Wang Wei , Du Zhonglin , Wang Jiuxing , Belfiore Laurence A. , Inganäs Olle , Tang Jianguo
Published: August 2024

In this work, Eu3+/Tb3+complexes were anchored into diatom shells and mixed with cellulose acetate, and the resulting films with excellent UV-absorption were applied to polymer solar cells, improving the cell efficiency and lifetime.
The impact of imidazolium with steric hindrance on the dissociation of phosphoric acid and the performance of high-temperature proton exchange membranes
Authors: Sun Xi , Yu Huiting , Guan Jiayu , Zhang Bin , Zheng Jifu , Li Shenghai , Zhang Suobo
Published: August 2024

This study proposes a strategy of blending polyimidazolium with strong steric effect in HT-PEMs in order to promote phosphoric acid dissociation and enhance proton conduction efficiency.
Enhanced charge transport of wide-bandgap perovskite solar cells enabled by crown ether-mediated crystal modulation
Authors: Zhong Han , Liu Xuanling , Wang Xuanyu , Yang Jianfei , Zhang Ziling , Li Jinxian , Liu Jianbo , Shen Heping , Lin Hong
Published: August 2024

Benzo-18-crown-6-ether was employed to regulate the crystallization of wide-bandgap perovskites, inducing the increased crystallinity and favorable crystal orientation, resulting in improved performance and stability of the corresponding devices.
Piezoelectric MoS2 with expanded interlayers: a flexible anode for a “zero” interfacial quasi-solid-state ammonium-ion asymmetric supercapacitor
Authors: Li Zixiao , Zhao Wenxi , Zhang Quanzhi , Zhou Qiang , Liang Jie , Cai Zhengwei , Zhang Min , Yang Chaoxin , Sun Shengjun , Luo Yongsong , Zheng Dongdong , Gong Feng , Yao Yongchao , Lin Yun , Sun Xuping
Published: August 2024

The unique piezoelectric effect of Exp-MoS2 significantly promotes NH4+ transfer and leads to a faster diffusion rate, making Exp-MoS2/CC act as an outstanding anode of an integrated ammonium-ion asymmetric supercapacitor.
Nanocellulose-short peptide self-assembly for improved mechanical strength and barrier performance
Authors: Marchetti Alessandro , Marelli Elisa , Bergamaschi Greta , Lahtinen Panu , Paananen Arja , Linder Markus , Pigliacelli Claudia , Metrangolo Pierangelo
Published: August 2024

A simple route to bio-based cellulose nanofibers (CNF) functionalization is here proposed via noncovalent incorporation of short peptides, enhancing rheology, hydrophobicity, and water vapor barrier properties in CNF-based hydrogels and films.
A self-assembling bioactive oligopeptide hydrogel for the treatment of edema following prepuce surgery
Authors: Liu Jianyong , Pei Yu , Huang Yingying , Jiang Haofei , Tadoh Mike Pleass Tita , Huang Xixi , Shen Jintao , Zeng Xiaoxi , Zheng Bin , Pan Jingye , Yang Guoqiang , Jiang Haihong , Chen Limin , Zhou Yunlong
Published: August 2024

A mono-component chiral nanofiber hydrogel dressing was developed through self-assembly of bioactive oligopeptide (Ac-FFFGHK-OH) to effectively treat edema following prepuce surgery.
Exceptionally low thermal conductivity in simple two-dimensional SiS: anomalous emergence of rattling phonon modes in non-caged materials
Authors: Zhang Tingting , Zhu Liyan
Published: August 2024

The Coulomb interaction among lone pair electrons localized at S atoms induces low-lying rattling phonon modes, resulting in ultralow thermal conductivity in 2D SiS.
Simultaneously enhancing hole extraction and defect passivation with more conductive hole-selective self-assembled molecules for efficient inverted perovskite solar cells
Authors: Wan Jiejie , Zhang Zijian , Lin Jinping , Li Zejiang , Liu Haifen , Li Qiaohong , Yang Shaopeng , Wang Lixin
Published: August 2024

Strategically designed self-assembled molecules (SAMs) of C-2PACz and S-2PACz are developed as hole-selective layers for efficient inverted perovskite solar cells.
An ultra-sensitive fluorescence multi-channel and colorimetric probe based on salicylaldehyde hydrazone for Al3+ recognition with a 3 : 1 binding ratio
Authors: Zhang Zhongyan , Wang Sha , Wang Muxi , Li Hongming , Liang Qingjian , Tang Jiawei , Sun Jian , Ma Li-Jun , Liu Hong
Published: August 2024

A salicylaldehyde hydrazone-based water-soluble fluorescence probe (SBN) for Al3+ was synthesized. The 3 : 1 binding mode between SBN and Al3+ generates multi-channel fluorescence recognition and a colorimetric response for Al3+.
Bridge-tuned through-space charge transfer for TADF and HLCT emissions
Authors: Tian Tian , Li Jiaqi , Guo Dongxue , Zhang Houyu
Published: August 2024

Structurally similar U-shaped D–A type molecules with dimethylxanthine (XAN) and anthracene (AN) as the bridge were constructed to realize TADF and HLCT emissions by tuning the through-space charge transfer (TSCT) between the donor and acceptor.
The influence of azide and imidazole on the properties of Mn- and Cd-based networks: conductivity and nonlinear phenomena
Authors: Trzebiatowska Monika , Kowalska Dorota A. , Ciżman Agnieszka , Wójcik Natalia A. , Barczyński Ryszard J. , Pikul Adam , Zaręba Jan K. , Palewicz Marcin , Piasecki Tomasz , Roleder Krystian , Gusowski Marek , Mączka Mirosław
Published: August 2024

We report a study on a family of four new Mn- and Cd-azide-imidazolate-based compounds with various crystal architectures.
Analysis of the impact of remote oxygen plasma treatment on the surface chemistry and electrochemical properties of graphite felt electrodes for redox flow batteries
Authors: Murillo-Herrera L. Mauricio , Mingoes Carlos J. , Obrero-Pérez J. , Sánchez-Valencia Juan R. , Thielke Michael W. , Barranco Ángel , Jorge Sobrido Ana B.
Published: August 2024

Remote oxygen plasma is compared to conventional thermal activation of electrodes for flow batteries and their impact on the mass transport and charge transfer properties of the resulting carbons.
ALMA-IMF
Authors: Louvet F. , Sanhueza P. , Stutz A. , Men’shchikov A. , Motte F. , Galván-Madrid R. , Bontemps S. , Pouteau Y. , Ginsburg A. , Csengeri T. , Di Francesco J. , Dell’Ova P. , González M. , Didelon P. , Braine J. , Cunningham N. , Thomasson B. , Lesaffre P. , Hennebelle P. , Bonfand M. , Gusdorf A. , Álverez-Gutiérrez R. H. , Nony T. , Busquet G. , Olguin F. , Bronfman L. , Salinas J. , Fernandez-Lopez M. , Moraux E. , Liu H. L. , Lu X. , Huei-Ru V. , Towner A. , Valeille-Manet M. , Brouillet N. , Herpin F. , Lefloch B. , Baug T. , Maud L. , López-Sepulcre A. , Svoboda B.
Published: August 2024

The stellar initial mass function (IMF) is critical to our understanding of star formation and the effects of young stars on their environment. On large scales, it enables us to use tracers such as UV or Hα emission to estimate the star formation rate of a system and interpret unresolved star clusters across the Universe. So far, there is little firm evidence of large-scale variations of the IMF, which is thus generally considered “universal”. Stars form from cores, and it is now possible to estimate core masses and compare the core mass function (CMF) with the IMF, which it presumably produces. The goal of the ALMA-IMF large programme is to measure the core mass function at high linear resolution (2700 au) in 15 typical Milky Way protoclusters spanning a mass range of 2.5 × 103 to 32.7 × 103 M⊙. In this work, we used two different core extraction algorithms to extract ≈680 gravitationally bound cores from these 15 protoclusters. We adopted a per core temperature using the temperature estimate from the point-process mapping Bayesian method (PPMAP). A power-law fit to the CMF of the sub-sample of cores above the 1.64 M⊙ completeness limit (330 cores) through the maximum likelihood estimate technique yields a slope of 1.97 ± 0.06, which is significantly flatter than the 2.35 Salpeter slope. Assuming a self-similar mapping between the CMF and the IMF, this result implies that these 15 high-mass protoclusters will generate atypical IMFs. This sample currently is the largest sample that was produced and analysed self-consistently, derived at matched physical resolution, with per core temperature estimates, and cores as massive as 150 M⊙. We provide both the raw source extraction catalogues and the catalogues listing the source size, temperature, mass, spectral indices, and so on in the 15 protoclusters.