bluuebunny/crossref_metadata_2025 huggingface dataset:
Kelola Bandwidth Dengan Menerapkan Algoritma Per Connection Queue Pada Jaringan Komputer Rajawali Kupie
Authors: Nanda Pratama Agung
Published: August 2024

In this day and age generally in places of business using the internet wifi as a tourist attraction for endings, such as coffee shop business. However, it is not uncommon to find wifi facilities provided by coffee shops or coffee shops that cannot be used, usually this is caused by the many users of the wifi network, not to mention one of the users who performs downloading or streaming activities. This causes the allocation of available bandwidth to be captured entirely by users who carry out these activities, resulting in no allocation of the remaining bandwidth for other users. Therefore it is necessary to have a bandwidth processing to regulate bandwidth allocation for wifi network users. One solution to this problem is to manage bandwidth using a proxy routerboard, a proxy routerboard will manage bandwidth to the network using the algorithm per connection queue (PCQ), this algorithm will allocate bandwidth evenly according to the number of users on the wifi network, so the bandwidth distribution the network is carried out fairly and equally. With this bandwidth management it is expected to help the coffee shop management in overcoming problems in the wifi network
Sistem Pendukung Keputusan Penerimaan Prodeo Pada Pengadilan Agama Medan Kelas I A Menerapkan EXPROM II
Authors: Feronika Sitinjak Dewi
Published: August 2024

-- Prodeo is a court litigation process for free with state funding through court DIPA (Article 1 paragraph 7). In receiving assistance for the general public, it is very important to know how the case is and so that the recipients of the aid can be right on target, there is no choice. In determining the acceptance of Prodeo Medan Religious Court Class 1 A, still using manual methods or there is no system to determine the receipt of a computerized prodeo. So with that the authors propose a computerized system in determining the acceptance of Predeo at the Medan Class 1 A Religious Court.The method that the author proposes in determining the Prodeo Recipient at the Medan Class 1 A Religious Court is the EXPROM II Method, namely the comparison of deviation or distance between alternative pairs for each criterion. In this method, the relative value of one of the alternatives is defined by two preference indices. So the procedure for admission of prodeo at the Medan Religious Court Class I A produces values ​​that can provide an overview in decision making, in order to get the right results for the acceptance of prodeo.
Analisa Fungsi Hash Untuk Mendeteksi Otentikasi File Video Menerapkan Metode N-Hash
Authors: Harianja Marjadi Hebert
Published: August 2024

The problem with the video scope is that the video can be watched by unauthorized people if the video file needs to be secured with good security. So it is necessary to design a video player application and apply encryption and description to the designed application. N-HASH can only produce 16 bytes of ciphertext while the input is different, namely if the input is 4 bytes then the output is 16 bytes and if the input is 16 bytes then the output is 4 bytes. The results of detecting authentication of video files have a lot of data if in bytes the data is very difficult to encrypt with N-HASH.
Data Mining Menentukan Pola Penjualan Kunci- Kunci Antik Dan Assesoris Rumah Dengan Algoritma Apriori
Authors: Lumbantoruan Ella
Published: August 2024

Sales are a business or concrete steps taken to transfer a product, whether in the form of goods or services. This research is motivated by the observations and experiences of researchers, problems that occur at UD. Suto whose service is not fast enough because of the accumulation of underutilized sales notes, and there is no research that is used to find out important information in order to increase sales and service. Sales activities at UD. The running Suto continues to cause accumulation of data because of the many sales transactions that occur every day and the longer it will increase.
The solution made in this study is to utilize sales transaction data so that the data is useful, it needs to be processed with a certain algorithm. This is done by processing the accumulated transaction data into useful information. By looking at the mapping of sales patterns, the relationship between items purchased by consumers can help managers determine product item displays based on consumer needs.
The priori algorithm is a data mining technique that is used to find high frequency patterns between itemset sets called the association rule function. A priori algorithms are part of data mining, which is the activity of collecting data and using old data to find regularities, patterns or relationships in data. The Apriori algorithm will form a predetermined number of frequent itemsets based on two parameters, namely support and confidence. The results of the itemset relationship between goods can be used to increase sales
Quality of life of children and young adults with Down syndrome from caregivers’ perspective: A systematic review and meta-analysis
Authors: Chan Yu Yi , Wong Bryan Wei Zhi , Cheok Fergus Edward , Tan Natania Rae Xiangqin , Kong Gwyneth , Amin Zubair , Ng Yvonne Peng Me
Published: August 2024

Introduction: Down syndrome (DS) negatively impacts the well-being of affected individuals. This study aimed to summarise the evidence on quality of life (QOL) of children and young adults with DS using quantitative measures from caregivers’ perspective and identify factors that affected their QOL.

Method: Database search was conducted on PubMed, Embase, Web of Science and CINAHL on 24 April 2024. Meta-analysis using random effects model was conducted where feasible. All studies underwent qualitative synthesis. The study protocol was registered with PROSPERO (CRD42023413532).

Results: Seventeen studies involving 3038 children with DS using various QOL measures were included: Pediatric Quality of Life Inventory (PedsQL) (8 studies), KIDSCREEN (4 studies), KidsLife (2 studies), The Netherlands Organization for Applied Scientific Research Academic Medical Center Children’s QOL (2 studies) and Personal Outcome Scale (1 study). Meta-analysis on PedsQL studies compared scores between children with DS and typically developing (TD) children. Total scale score was lower in children with DS (mean 70.28, 95% confidence interval [CI] 64.31–76.24) compared to TD children (mean 88.17, 95% CI 80.50–95.83). All subdomains of PedsQL were also lower in children with DS. Within the domain of psychosocial health, children with DS had statistically significant lower social functioning (standardised mean difference -1.40, 95% CI -2.27 to -0.53) and school functioning (standardised mean difference -1.09, 95% CI -1.55 to -0.62) scores, but similar emotional functioning scores. Qualitative synthesis revealed poorer subdomain QOL compared to TD children, especially in social functioning and cognitive functioning. QOL worsened during adolescent years. Family variables (parental education and occupation) did not affect parental perception of children’s QOL. Children with DS who had higher intelligent quotient had better QOL.

Conclusion: Children with DS have lower caregiver-reported QOL than TD children, especially in social functioning and school functioning subdomains.
Optimizing RAG with Hybrid Search and Contextual Chunking
Authors:   USA, Bansal Ashish
Published: August 2024

Large pre-trained language models have been shown to store factual knowledge in their parameters, and achieve state- of-the-art results when fine-tuned on down- stream NLP tasks. However, their ability to access and precisely manip- ulate knowledge is still limited, and hence on knowledge- intensive tasks, their performance lags behind task-specific architectures. Additionally, providing provenance for their decisions and updating their world knowledge remain open research problems. Pre- trained models with a differentiable access mechanism to explicit non-parametric memory have so far been only investigated for extractive downstream tasks. Retrieval-Augmented Generation (RAG) is a prevalent ap- proach to infuse a private knowledge base of documents with Large Language Models (LLM) to build Generative Q&A(Question-Answering) systems. However, RAG accu- racy becomes increasingly challenging as the corpus of docu- ments scales up,with Retrievers playing an outsized role in the overall RAG accuracy by extracting the most relevant document from the corpus to provide context to the LLM. In this paper, we propose different ways to optimize the re- treivals, Reciprocal Rank Fusion, Reranking and dynamic chunking schemes.
Unraveling The Emotional Psyche of Former Employees: An Exploratory Study
Authors: Dr. Mallanna.I.Biradar
Published: August 2024

This research delves into the emotional experiences of former employees, shedding light on the complex psychological dynamics at play. Through in-depth interviews and surveys, we uncover the emotional trajectories of individuals’ post-employment, revealing themes of nostalgia, relief, anxiety, and personal growth. Our findings provide valuable insights for organizations to improve employee exit processes and foster positive alumni relationships. Employee turnover is a natural phenomenon, yet its emotional implications on former employees remain understudied. This study provides a nuanced understanding of the emotional psyche of ex-employees, emphasizing the need for organizations to prioritize humane exit processes and nurture ongoing connections with former employees. This research aims to bridge this gap by exploring the emotional psyche of ex-employees.
Cardiovascular toxicity profile of immune response checkpoint inhibitors
Authors:   South Ural State Medical University, Chelyabinsk, Russia, Kharlamova Ulyana V. , Vazhenin Andrei V. ,   South Ural State Medical University, Chelyabinsk, Russia, Kurchenkova Olga V. ,   South Ural State Medical University, Chelyabinsk, Russia, Brosalina Alina A. ,   South Ural State Medical University, Chelyabinsk, Russia, Troyan Ksenia N. ,   South Ural State Medical University, Chelyabinsk, Russia
Published: August 2024

The introduction of immune response checkpoint inhibitors is a step toward an innovative treatment paradigm, but along with increased antitumor efficacy may come a potential increase in cardiotoxicity. Objective. To study the frequency of clinical manifestations of early cardiovascular toxicity during IcT administration in patients with malignant neoplasms. Materials and methods. 47 patients (27 men, 20 women), mean age 59,5±7,38 years were included in the prospective study. clinical cardiovascular symptoms, dynamics of blood pressure, laboratory parameters (c-reactive protein (crP), troponin I, n-terminal fragment of brain natriuretic peptide precursor (nT-proBnP), electrocardiogram and echocardiography data initially and in the dynamics of antitumor drug treatment in 3 months or earlier, at the onset of cardiovascular symptoms, were analyzed. Results. during the follow-up period, the incidence of adverse clinical cardiovascular events was 17.6% (n=6). Atrial fibrillation first manifested in 5.8% (n=2), symptoms of heart failure – in 8.8% (n=3), 2.9% (n=1) developed acute cerebral circulatory failure. In 3 patients (8.8%) cardiovascular manifestations were combined with lack of arterial hypertension control, which required correction of hypotensive therapy. moderate cardiac dysfunction developed in 5.9% (n=2) of patients, in 2.9% (n=1) – mild myocardial dysfunction according to ecHocG-criteria and changes in the level of biomarkers. There was a tendency to increase nT-proBnP level (p=0.051), crP level (p=0.05). There was a statistically significant decrease in LVeF (p=0.02). manifestation of cardiovascular complications in patients with malignant neoplasms against the background of IcT therapy was associated with age (β=0.32; p=0.07), crP level (β=0.46; r2=0.22; p=0.005) (model – multiple linear regression). Conclusions. First-time cardiovascular complications on the background of therapy of malignant neoplasms with checkpoint inhibitors are detected with high frequency (17.6%), characterized by a decrease in left ventricular ejection fraction, associated with the level of c-reactive protein and age of patients.
A Critical Assessment of the Impact of the Domestic Environment on Foreign Policy
Authors: Al-Fahad Fahad A.F.S
Published: August 2024

The domestic environment plays a considerable role in shaping a nation’s foreign policy as it can affect decision-making processes and international relations. However, the extent of such impact remains a subject of debate among policymakers and scholars. In this context, this paper aims to critically assess the influence of domestic factors on foreign policy through the perspectives of two contrasting theories: Pluralism and Elitism. Understanding the intricate relationship between domestic factors and foreign policy is essential in comprehending the driving forces behind a country's international actions and the decision-making processes in foreign policy.
Brain and Stunting: Integrative Clinical and Community Stunting Prevention Perspectives in Disorders of Brain Development
Authors: Ali Asriadi
Published: August 2024

Stunting is a health problem that is very urgent to be addressed. This is associated with increased morbidity, mortality, development of cognitive impairment and an increased risk of various chronic diseases in the future. The research method uses a qualitative approach. With the literature review method, which includes activities related to library data collection methods, reading and recording, and managing research materials. The results of the study show that the treatment of stunting can be divided into 2 methods. First, specific interventions that contribute 30% to the success of treatment, are aimed at children within the First 1,000 Days of Life (HPK), are generally carried out by the health sector and are short-term in nature. This can be done through the target group of adolescents and women of childbearing age, pregnant women, nursing mothers and children 0-23 months, children 24-59 months through priority, important and conditional interventions. The two sensitive interventions, which contribute 70%, are aimed at various development activities outside the health sector targeting the general public. The types of interventions that can be carried out are increasing the supply of drinking water and sanitation, increasing access to and quality of nutrition and health services, increasing awareness, commitment, parenting practices, maternal and child nutrition, increasing access to nutritious food.
Anticipating for Sustainability: A Stopover in Congolese Family-Owned SMEs
Authors: Théophile Bindeouè Nassè Prince Valnis Kester Moloumba Mokango
Published: August 2024

Purpose : In a highly competitive environment, the question of the sustainability of family-owned SMEs has become a major concern for managers and academics. With this in mind, the objective of this research is to identify how anticipations contribute to the sustainability of family-owned SMEs. Design/Approach / Methodology : To do this, a qualitative methodology is used, through semi-structured interviews, with thirty-six actors in the field. Findings : It appears that anticipation as a life-giving force, a catalyst for the future, a vector of sustainability and a tool for good governance helps family-owned SMEs to live for a long time in an uncertain geographical sphere. Practical implications : It implies that SMEs should build their internal system such in a way that they are able to anticipate challenges in order to enhance their organisational sustainability.
Assessing Eudaimonic Factors in Young Urban Indian Students: Gender and Social Media Influence on Resilience
Authors: Goswami Sutapa , Brahmi Mannu , Jain Riya , Sharma Greeshma
Published: August 2024

This study investigates the role of eudaimonic factors such as ‘quiet ego’ and ‘non-attachment’ in fostering resilience among young adults in urban India, examining the interplay of these constructs with gender, social media usage, and psychological profiles. Utilizing a sample of 200 participants aged 20-25 from urban India, this study employed the ‘Quiet Ego Scale,’ ‘Non-attachment Scale,’ and ‘Resilience Scale.’ Data were analyzed using t-tests and ANOVA on R-Jamovi. The findings indicate significant gender differences, with males exhibiting higher scores in non-attachment and resilience than females. Additionally, participants with lower to moderate social media usage (1-2 hours per day) displayed greater resilience compared to heavy users (more than 3 hours/day). These results underscore the need for understanding the factors that predict resilience, as gender and social media habits significantly influence resilience in young adults. This understanding can inform the development of targeted interventions and support systems that cater to diverse groups based on their unique psychological needs and social habits. For instance, interventions could be designed to help individuals, particularly females and heavy social media users, develop a ‘quiet ego’ and ‘non-attachment’ mindset, thereby enhancing their resilience.
“The Gender Dimension of Abusive Marriage Relationships in the Modern Zimbabwe” Insights from Harare
Authors: Grizzah Briges , Mazwi Nicola , Munyira Enia , Chatira Getrude
Published: August 2024

Domestic violence cases are seemingly on the rise in the Zimbabwean context, the most enduring and victimised group are the women. The patriarchal hegemony is still dictating the politics of domestic affairs of the modern day, and women as the main victims of most domestic violence cases tend to stay in the relation regardless of enormous abusive challenges. It is from this background that this research was conducted to examine contributing factors that forces women to stay in abusive relationships. The qualitative methodology was chosen as the most appropriate methodology to test the research question of this topic. The population for research was based on women in Harare, and the sample was drawn from voluntary women in a local Non-Governmental Organisation (NGO) that specialises in domestic violence related issues known as the Anti-Domestic Violence Council (ADVC) (n=10). The interview guide was chosen as the most appropriate tool for exploration of data from the participants, and data was analysed and presented based Anti-Domestic Violence Council (ADVC) using thematic analysis. It come out that cases of domestic violence are prevalent in many marriage relationships in the modern Zimbabwe. Factors such as culture, fear and lack of knowledge amongst many contribute to women’s endurance to abusive relationships.
Teenage Pregnancy among Senior High School Students in Ghana: Causes, Effects and Prevention
Authors: Amoah-Saah Isaac , Akosah Jones Clifford
Published: August 2024

From classroom to cradle, unravelling the crisis of teenage pregnancy in Ghana’s senior high schools and charting a path to prevention has become very crucial. The main objective of this study was to examine the causes, effects, and prevention of teenage pregnancy among students in Senior High Schools in Ghana. Three research questions guided the study. The study employed cross-sectional descriptive survey design. The target population of the study consisted of all third year Senior High School (SHS) students totaling 1,370. A sample size of 300 students was selected for the study. Descriptive statistics was used to analyze the research data. It was concluded that teenage pregnancy is mainly caused by lack of education on the causes, effects and prevention of the phenomenon. It was also concluded that negative peer group influence and poverty can lead to teenage pregnancy. It was observed from the study that the main source of education on teenage pregnancy is the parents. Furthermore, it was observed that poverty is one of the effects of teenage pregnancy. It was recommended that parents should ensure proper supervision and monitoring of their children. Parent should give their children appropriate sex education and sanction them when necessary. Sex education should be taught as a stand-alone subject instead of being integrated into other subjects such as religious and moral education as is found in the current curriculum. This will help broaden the scope of teenage pregnancy education and increase the time allocated for its teaching and creating room for parents and other resource persons to share their rich experiences with the school children.
Nicotine Addiction among Physical and Health Education Pre-Service Teachers
Authors: Mohamad Zahir Irfan Sodiqin , Zulkifli Ahmad Fahim
Published: August 2024

Nicotine addiction is defined as the compulsive need to seek or use a substance despite its harmful effects and negative consequences. This study aims to identify the factors contributing to nicotine addiction, examine its effects, and assess the frequency of nicotine use among Physical and Health Education pre-service teachers at Central University. A quantitative research method was employed, involving the distribution of questionnaires during the pre-test, intervention, and post-test phases. In the first phase, demographic information and pre-test questionnaires were collected. Participants were then given five weeks to watch five educational videos, one per week. The second phase involved distributing post-test questionnaires to assess changes. Data were analyzed using SPSS software. The findings revealed that participants were interested in the educational videos and felt motivated to reduce nicotine intake in their daily lives. There was a significant improvement in the pre-test and post-test results across all three research questions. In summary, this study focused on nicotine addiction among Physical and Health Education pre-service teachers at Central University. Utilising a quantitative approach and educational videos, participants showed increased interest and motivation to quit nicotine intake. The post-test results indicated a significant improvement across all research questions, highlighting the effectiveness of educational interventions in raising awareness and potentially reducing nicotine addiction among the students. This underscores the importance of targeted educational efforts in fostering healthier habits among this population.
INTERVENÇÕES PRÉVIAS À FERTILIZAÇÃO IN VITRO EM MULHERES COM ENDOMETRIOSE
Authors: De Oliveira Rodrigues Estela , Campolina Gomes Ana Luiza , Decker Renan Victor , Guedes Dutra Maciel Mayara
Published: August 2024

A fertilização in vitro (FIV) é um meio de reprodução humana assistida que permite homens e mulheres com problemas de fertilidade a alcançarem uma gestação. Em mulheres com endometriose, onde a infertilidade é uma queixa frequente, a FIV é uma das alternativas para aquelas que desejam uma gestação. Objetivos: analisar os benefícios e malefícios da realização de intervenções médicas antes da fertilização in vitro em mulheres com endometriose. Metodologia: Após o auxílio da inteligência artificial para a definição do tema, a pesquisa foi realizada através dos seguintes descritores “Endometriosis”, “in vitro fertilization” e “Infertility” junto ao booleano AND, nas plataformas de dados PubMed, SciELO e Lilacs, limitando os artigos aos anos de 2019 a 2023. Após aplicar os critérios de inclusão e exclusão, foram analisados 7 artigos. Resultados e discussões: A análise dos estudos incluíram resultados satisfatórios ao uso de medicações associadas e à intervenção cirúrgica prévia. Medicamentos isolados requerem prosseguir pesquisa.  Conclusão: O uso combinado de intervenção cirúrgica e farmacológica mostrou-se superior ao procedimento direto da fertilização. O uso isolado de progesterona necessita maior investimento científico para análise dos resultados; a administração de GnRH-a ou G-CSF não apresentou conclusão satisfatória.
الرسائل الإنسانية والجوانب الروحانية في نثر الغني والفير لمصطفى لطفي المنفلوطي
Authors: Khairah Nur Ulfani
Published: August 2024

يعبر المنفلوطي في مؤلفاته النظرات عن المشكلات التي يعيشها المجتمع المصري بعنوان "الغني والفقير". ومشكلة البحث في هذه الرسالة هي: 1) ما هي الرسائل الإنسانية في نثر الغني والفقير؟ و 2) ما هي الجوانب الروحانية في نثر الغني والفقير؟. وأما منهج البحث في هذه الرسالة فهو الوصفي الكيفي، ونوعه الدراسة المكتبية، ومصادر البيانات هي نثر الغني والفقير والكتب والبحوث العلمية التي تتعلق به. وطريقة تحليل البيانات هي تحديد البيانات، ووصف الخصائص، وتحليل الخصائص، ووضع توضيح شامل، واستخلاص النتائح. وأما بالنسبة لنتائج البحث، فوجدت الباحثة أن الرسائل الإنسانية في نثر الغني والفقير تتكون من أربعة أنواع هي علاقة الإنسان بالله، والعلاقات الإنسانية، وعلاقة الإنسان مع البيئة، وعلاقة الإنسان بنفسه. وأما الجوانب الروحانية في نثر الغني والفقير تتكون من تسعة أنواع فهي البعد المتعالي فيه، والمعنى والهدف في الحياة فيه، ومهمة الحياة فيه، وقدسية الحياة فيه، والقيم المادية فيه، والإيثار فيه، والمثالية فيه، والوعي بالأحداث المأساوية فيه، وثمرة الروحانية فيه.
الكلمات الرئيستية: الرسائل الإنيسانية، الجوانب الروحانية، مصطفى لطفي المنفلوطي، نثر الغني والفقير
ANALISIS KEPEMIMPINAN ABDUL MALIK FADJAR DALAM MEMBESARKAN UNIVERSITAS MUHAMMADIYAH MALANG
Authors: Shofwan Arif Muzayin
Published: August 2024

The size and size of a university cannot be separated from its leadership. This research analyzes the leadership of Abdul Malik Fadjar, namely a leader who has succeeded in growing the University of Muhammadiyah Malang (UMM) to become the largest private university in Eastern Indonesia. The data analysis technique uses content analysis by sorting things according to the focus and objectives of the research. This research found that the first step taken by Abdul Malik Fadjar and his colleagues was to formulate big ideas or ideals that had dimensions far into the future. After obtaining this picture, we then carry out stages in managing higher education, namely the consolidation stage, physical development stage, and academic development stage. The consolidation stage aims to concentrate all potential and eliminate all challenges and obstacles in order to achieve the desired goals, which includes three aspects, ideal consolidation, structural consolidation, and personal consolidation. The physical development stage was carried out by borrowing money from the bank, then remodeling the simple campus into a magnificent three-story campus, and acquiring land for future campus expansion. The academic development stage is carried out by creating a program to improve the quality of lecturers, recruiting permanent lecturers, and conducting a large-scale hunt for permanent lecturers through the Service Bond Allowance (TID) route to save campus costs.
Extracurricular Entrepreneurship and Enterprise Education: What, How, Why, For Whom, and When?
Authors: Fauchald Ragnhild
Published: August 2024

This study investigated what, how, why, for whom, and when extracurriculars add to entrepreneurship and enterprise education to examine the roles of extracurriculars in entrepreneurship and enterprise students' education and learning processes. A systematic literature review method was chosen as it enables to identify characteristics of extracurricular entrepreneurship and enterprise education (EEE) through synthesis of validated studies of the phenomena. Findings indicate that EEE differs from formal EE owing to the influence of voluntariness and students' engagement in the EEE. Students' engagement in EEE and the motivation behind their engagement will be fundamental in the understanding of why, when, whom and how students engage and the outcome of engaging. The study contributes to the EE literature by addressing how the uniqueness of voluntarily participating in EEE influences learning situations, which distinguishes EEE from formal EE. Thus, the study has implications for research regarding how EEE and different EEE activities and initiatives need to further be explored to understand the potential of learning from participation in extracurricular entrepreneurship and enterprising education. The study provides implications for practice in regard of how EEE can be organized to foster learning.
Spectrum of Lower Respiratory Bacterial Pathogens and their Antimicrobial Susceptibility in a Tertiary Care Hospital at Rawalpindi
Authors: Mehmood Ammarah , Mirza Irfan Ali , Farooque Abid , Mehmood Umer , Zill-e-Huma  , Saba Aslam Mehwish
Published: August 2024

Objective: To study the spectrum of bacterial etiological agents causing lower respiratory tract infections and their antimicrobial susceptibility pattern in a tertiary care hospital at Rawalpindi.
Methodology: A descriptive, cross-sectional study was conducted in the department of Microbiology, Armed Forces Institute of Pathology (AFIP), Rawalpindi from June to December 2021. Total 130 patients with lower respiratory tract infections (LRTIs) irrespective of age and gender were included in the study while patients of pulmonary tuberculosis, fungal diseases and patients having prior antibiotic therapy before sample collection were excluded. Non quantitative cultures were performed for sputum, non- directed bronchial lavage (NBL), pleural fluid and quantitative cultures for bronchoalveolar lavage (BAL) and endobronchial (EB) washings specimens. Antibiotic susceptibility was performed using Clinical and Laboratory Standards Institute (CLSI) 2021 guidelines.
Results: Pseudomonas aeruginosa (26.9%) was found to be the most prevalent bacterial pathogen followed by Klebsiella pneumoniae (23%). Both Gram negative and Gram-positive bacteria showed highest antimicrobial resistance to flouroquinolones. Gram negative bacteria were more susceptible to aminoglycosides and carbapenems. Gram positive bacteria were most susceptible to linezolid and vancomycin. Staphylococcus aureus was isolated from 8 samples, of which 5(62.5%) were Methicillin-resistant Staphylococcus aureus (MRSA).
Conclusion: This study concluded that the most frequent bacterial pathogen causing lower respiratory tract infections was Pseudomonas aeruginosa and both Gram negative and Gram-positive bacteria showed highest antimicrobial resistance to flouroquinolones.
Evaluation of Acute Toxicity of Ethanolic Extract from Fruit of Cyanometra cauliflora in ICR Mice
Authors: Somsap On-Anong , Payanglee Kolip , Kamnate Anussara , Singdam Patcharin
Published: August 2024

This research aims to investigate the acute toxicity profile of the ethanolic extract derived from Cyanometra cauliflora fruit, a plant commonly found in Southeast Asia. Male ICR mice were divided into 5 groups and administered varying oral doses of C. cauliflora extract: 100, 200 and 400 mg/kg body weight. Subsequently, the effects on both histological and biochemical parameters were meticulously examined post-experimentation. The results indicated no significant alterations in blood glucose or blood urea nitrogen (BUN) levels attributable to C. cauliflora extract administration. Nevertheless, a noteworthy elevation in creatinine, aspartate transaminase (AST), and alkaline phosphatase (ALP) levels was observed across all groups treated with C. cauliflora extract in comparison to controls (p < 0.05). Intriguingly, the extract consistently elicited a reduction in triglyceride levels across all administered doses, while cholesterol levels exhibited a decline specifically at the 400 mg/kg body weight dose. Notably, the levels of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) remained unaltered throughout the experimentation. Histological assay suggested signs of hepatocellular damage, portal dilation and infiltration of inflammatory cells across all C. cauliflora-treated groups, alongside indications of kidney atrophy and other abnormalities.
               These findings collectively suggest structural and functional modifications induced by C. cauliflora extract. In summary, while the administration of C. cauliflora extract did not exert significant changes in blood glucose and BUN levels, it did lead to heightened levels of creatinine and liver enzyme markers. Furthermore, liver and kidney damage were discerned at doses ranging from 100 to 400 mg/kg body weight, underscoring the imperative need to optimize extract concentrations to mitigate potential cytotoxic effects. These findings can be further explored to understand the processes behind the observed effects and to assess potential therapeutic applications or safety considerations associated with the use of C. cauliflora extract in clinical settings.
HIGHLIGHTS

A hepatic and renal toxicity profile was detected in the ethanolic fruit extract of Cyanometra cauliflora, despite the absence of fatalities.
The ethanolic fruit extract of cauliflora L. lowered cholesterol and triglyceride levels.
Prolonged ingestion could be detrimental.

GRAPHICAL ABSTRACT
Advances of Chitosan-based Hydrogel Scaffolds for Cartilage Tissue Engineering: Preparation, Modification, and Future Perspective
Authors: Sudarta Ancilla Angellie , Sari Putu Addelia Puspa , Halim Theodora Clarissa , Setiawati Agustina
Published: August 2024

A cutting-edge field of study to create biological substitutes to maintain, restore, or enhance cartilage function is articular cartilage (AC) tissue engineering. Employing this innovative approach, polymer composites that mimic the structure and function of real cartilage tissues are created by carefully mixing biomaterials of scaffolds, cells, and biochemical components. Naturally polymers have recently gained attention as biomaterials to fabricate scaffolds, for instance, chitosan. Despite its shortcomings such as poor mechanical strength and low stiffness, chitosan-based hydrogel scaffolds have been cross-linked with other synthetic polymers, namely hybrid scaffolds, for future perspective of AC tissue engineering. To mimic AC compartment design, additive manufacturing closely resembles native tissue, and its flexibility is possibly tailored.
HIGHLIGHTS

Chitosan emerges as a valuable scaffold due to its structural similarity to glycine aminoglycan of extracellular matrix (ECM).
Overcoming obstacles in scaffold design, innovative approaches like gradients and composite multilayer scaffolds resembling cartilage tissue are developed.
The integration of elements like minerals, growth factors, and cells, along with advancements in mechanobiology and bioreactor design, is set to play a crucial role in cartilage tissue engineering.
The advent of three-dimensional (3D) printing, especially with chitosan and synthetic polymer hydrogel inks, holds promise for creating stable structures.

GRAPHICAL ABSTRACT
The Effects of Pentoxifylline Administration on TGF-β1 Expression in Rats with Radiation-Induced Muscle Fibrosis
Authors:   Istanbul University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, GASIMLI Gunay
Published: August 2024

The aim of this study was to investigate the potential influence of pentoxifylline (PTX) administration on transforming growth factor beta 1 (TGF-β1) expression and the development of radiation-induced fibrosis (RIF) in Sprague-Dawley rats. Seventeen rats (n= 17) were randomly divided into four groups: The first one received a single dose equivalent to 90 Gy of radiotherapy (RT) to the rectus femoris muscle, the second received PTX administration (25 mg/kg/day) via gavage in addition to irradiation (RT+PTX), the third group received only PTX, and the fourth group served as the controls. At the end of 24 days, fibrosis formation was assessed by light microscopy. The TGF-β1serum and tissue levels were assessed with enzyme-linked immunosorbent assay (ELISA) and reverse transcription polymerase chain reaction methods. Immunohistochemical staining revealed focal punctate cytoplasmic TGF-β1 staining in the irradiated group compared with the control group. Morphological changes, including increased oedema and mild collagen thickening, were observed in both the RT and RT+PTX groups. Reverse transcription polymerase chain reaction results revealed no significant differences between the RT, PT+PTX, PTX, and Control group. ELISA results showed substantial differences between the RT, RT+PTX, PTX, and Control group (p= 0.125). The Control group without therapy exhibited higher ELISA results. PTX administration did not demonstrate a positive effect on the serum and muscle expression of TGF-β1 in rats with fibrosis induced by a single dose of radiation. Additionally, TGF-β1 may not be a reliable marker of fibrosis that can be routinely used in the early stages of similar radiotherapy-related tissue damage. Keywords: Pentoxifylline, Fibrosis, Radiation therapy, TGF-β1 expression
"Immersion, Reflection, Triangulation: Festival Research Methods in Small and Precarious Cinemas", Chapter 6 in Shaping Film Festivals In a Changing World: Practice and Methods, eds. Ostrowska and Falicov
Authors: Vanhaelemeesch Jasper
Published: August 2024

The goal of the chapter is to offer alternative and complementary methodological approaches to the study of (small) film festivals in small and precarious film cultures through a post-Third-Worldist lens (Shohat, 1997). Central is the idea that the selected methodological and theoretical frameworks arise in dialogue with the research contexts and subjects. Such a grounding of the approach has as its aim to analyse cultural expression where it originates, instead of acknowledging its existence solely based on international circulation or reflecting on discursive acts based on unilaterally imposed western ideas on aesthetics and representation. The proposed methods are based in anthropological fieldwork and sociological studies of film and media.
Risk factors associatedwith early complications following laparoscopic surgery for gastric cancer
Authors: Tran Quoc Hanh ,   Huỳnh Quang Nghệ1, Võ Duy Long2
Published: August 2024

Tóm tắt
Đặt vấn đề: Phẫu thuật nội soi điều trị ung thư dạ dày đã được chứng minh với nhiều ưu điểm hơn so với mổ mở, tuy nhiên thực tế vẫn chưa thể khắc phục hết các biến chứng có thể xảy ra. Nghiên cứu này nhằm khảo sát các biến chứng và đánh giácác yếu tố nguy cơ của biến chứng sớm sau mổ.
Đối tượng và phương pháp nghiên cứu: Hồi cứu 511 trường hợp phẫu thuật nội soi cắt dạ dày điều trị ung thư dạ dày tại Bệnh viện Đại Học Y Dược Thành phố Hồ Chí Minh từ 01/2017 đến 05/2022.
Kết quả: Tỉ lệ biến chứng chung sau mổ 15,1%. Tỉ lệ biến chứng tại chỗ 11,7%. Tỉ lệ biến chứng toàn thân là 5,5%. Tỉ lệ tử vong sớm sau mổ 0,8%. Các yếu tố nguy cơ của biến chứng sớm sau mổ gồm: BMI, tiền căn mổ bụng trên, có bệnh kèm theo, vị trí u, giai đoạn T, lượng máu mất.
Kết luận: Mỗi người bệnh cần được đánh giá toàn diện về các yếu tố nguy cơ. Từ đó có biện pháp can thiệp phù hợp nhằm giảm thiểu các rủi ro có thể xảy ra.
Từ khóa: ung thư dạ dày, phẫu thuật nội soi, cắt dạ dày, yếu tố nguy cơ và biến chứng.

Abstract
Introductions: Laparoscopic surgery for gastric cancer has been demonstrated several advantages in comparison with open surgery. However, in clinical practice, not all potential complications could be completely eliminated. This study aims to investigate the overall complications to find the risk factors associated with early postoperative complications.
Patients and methods: A retrospective study was conducted on 511 cases of laparoscopic gastrectomy for gastric cancer at the University Medical Center, Ho Chi Minh City from 01/2017 to 05/2022.
Results: The overall complication rate after surgery was 15.1%. The complication related to surgical procedures rate was 11.7%. The systemic complication rate was 5.5%. The early postoperative mortality rate was 0.8%. Risk factors associated with early postoperative complications included BMI, previous upper abdominal surgery, comorbidities, tumor location, tumor stage T factors and blood loss.
Conclusions: A thorough comprehensive evaluation should be implemented on every patient. Proper intervention measures therefore could be proposed to minimize potential risks that may arise.
Keywords: gastric cancer, laparoscopic surgery, gastrectomy, risk factors and complications.
Analisis Kesuksesan Sistem Informasi Akademik Menggunakan Model Sukses Delone dan Mclean
Authors: Pebrianto Rangga , Maulina Phitsa , Nugraha Siti Nurhasanah , Cahya Fani Nurona
Published: August 2024

Sistem informasi akademik digunakan oleh perguruan tinggi karena banyaknya tantangan dan masalah yang dihadapi. Dengan mengadopsi dan memanfaatkan teknologi informasi, perguruan tinggi berusaha untuk meningkatkan efektivitas dan efisiensi kinerja mereka dalam proses akademiknya. Tujuan penelitian ini guna evaluasi faktor apa saja yang berpengaruh terhadap efektivitas SIAKAD di Universitas Bina Sarana Informatika PSDKU Tasikmalaya untuk dianalisis keberhasilannya. Model Delone & Mclean digunakan sebagai dasar model penelitian. Kuesioner yang telah disiapkan dibagikan kepada mahasiswa, staf dan dosen di lingkungan Universitas Bina Sarana Informatika PSDKU Tasikmalaya responden yang memenuhi persyaratan sebagai pengguna SIAKAD UBSI. Dari kuesioner yang disebar terdapat 95 responden menjawab dengan benar dan valid. Regresi linier berganda digunakan untuk mengolah data setelah diperoleh data yang valid dan reliabel melalui uji validitas dan reliabilitas. Berdasarkan hasil analisis deskriptif presentase responden berpendapat terhadap pernyataan yang disajikan pada kuesioner adalah 46% â€œSangat Setujuâ€, 47% menyatakan â€œSetujuâ€, dan 7% berpendapat â€œCukup Setujuâ€. Dilihat dari nilai thitung masing-masing hipotesis yang diuji melebihi ttabel yang telah ditentukan, maka hasil uji hipotesis menunjukkan bahwa 12 hipotesis diterima dalam penelitian ini. Hasil penelitian ini menunjukkan bahwa penerapan SIAKAD UBSI khususnya di PSDKU Tasikmalaya telah efektif dalam membawa manfaat bagi pengguna dalam hal kualitas sistem, kualitas informasi, dan layanan yang disediakan.
Penerapan Metode Forward Chaining pada Sistem Pakar Diagnosa Penyakit Tanaman Kelapa Sawit
Authors: Dewi Sri
Published: August 2024

Sitem Pakar adalah sistem berbasis komputer yang dirancang untuk dapat meniru keahlian seorang pakar dalam memecahkan masalah. Metode  yang digunakan  dalam perancangan sistem pakar ini adalah metode Forward Chaining. Metode Forward Chaining merupakan suatu metode penalaran yang dimulai dari fakta untuk mendapatkan kesimpulan. metode Forward Chaining digunakan dalam sistem pakai ini sehingga dapat mendiagnosa penyakit tanaman kelapa sawit dan dapat memberikan solusi serta cara pengendalian penyakit tanaman kelapa sawit yang terserang penyakit berdasarkan gejala-gejala yang dipilih oleh user. Ada 5 jenis penyakit tanaman kelapa sawit dan 19 gejala penyakit tanaman kelapa sawit dengan 11 rule yang diterapkan dalam sistem pakar yang dirancang. Hasil prosedur ini akan menghasilkan fakta - fakta penyakit tanaman kelapa sawit dan solusi yang ditawarkan sistem untuk selanjutnya dilakukan penanganan pada tanaman kelapa sawit.
Virtual Tour 360 Degree Pengenalan Pura Luhur Batu Panes Bali Berbasis Website
Authors: Kristilya Dewi Putu , Suardika I Gede , Setyarini Putu
Published: August 2024

Pura Luhur Batu Panes adalah pura Kahyangan jagat yang berada di Desa Mengesta Penebel Tabanan Bali. Pura Luhur Batu Panes memiliki keberadaan yang unik karena terdapat peninggalan bersejarah berupa arca Ganesha dan Lingga yoni, serta sumber mata air panas yang menurut kepercayaan masyarakat selain dapat memberikan kesehatan, dapat juga menyembuhkan penyakit. Sangat disayangkan jika masih ada masyarakat yang belum mengetahui keunikan dan keberadaan Pura Luhur Batu Panes. Pemanfaatan teknologi yang tepat diharapkan dapat membantu menyelesaikan masalah tersebut. Virtual Tour 360 Degree adalah Teknologi yang dapat membantu menyelesaikan masalah tersebut. Dengan keberadaan aplikasi ini dapat menjadi media promosi. Pembuatan Virtual Tour ini dilakukan dengan menerapkan metode MDLC. Beberapa kesimpulan diperoleh dari hasil rancang bangun yang telah dilakukan, yaitu telah berhasil dibangun sebuah aplikasi Virtual Tour 360 Degree Pengenalan Pura Luhur Batu Panes yang diawali dengan proses Analisa 5W+1H, analisa SWOT, lalu proses pengujian aplikasi dengan metode Black Box Testing menggunakan dua buah teknik yaitu halaman front-end diuji dengan teknik State Transition Diagram (STD), sedangkan halaman back-end diuji dengan teknik Equivalence Partition yang menunjukkan bahwa semua fitur aplikasi berjalan sesuai dengan apa yang diharapkan. Diterapkan metode SUS untuk pengujian di sisi pengguna dengan diperoleh skor sebesar 83,17 yang menempatkan aplikasi ini dalam kategori yang sangat baik (Grade B) sehingga dianggap layak digunakan.
RANCANG BANGUN PROGRAM PERSEDIAAN BARANG BERBASIS DESKTOP PADA PT. BIOSANT TIRTA LESTARI KOTA BEKASI
Authors: Zaky Muhammad , Rakhmah Syifa Nur
Published: August 2024

PT. Biosant Tirta Lestari sebuah perusahaan yang bergerak dalam bidang kontraktor, dan saat ini proses pencatatan data barang masih meggunakan alat pengolahan data yang sederhana, sehingga sering mengakibatkan kesalahan dalam pencatatan data barang, transaksi keluar masuknya barang dan pembuatan laporan yang keakuratannya kurang serta memerlukan waktu sedikit lama dalam proses pencarian data barang. Rancang bangun sistem informasi persediaan barang berbasis desktop adalah solusi terbaik untuk memecahkan masalah yang terdapat pada bagian gudang PT. Biosant Tirta Lestari. Dalam proses disusunnya penelitian ini membutuhkan dua metode penelitian yakni pengumpulan data dan bagaimana pengembangan perangkat lunak dengan menggunakan metode waterfal. Desain dibuat menggunakan UML dan pembuatan program aplikasi desktop ini dirancang memakai bahasa pemrograman Java dan untuk database server menggunakan MySql. Hasil dari rancang bangun aplikasi persediaan barang adalah memudahkan karyawan khususnya di bagian pergudangan dalam mengelola data barang, pembuatan surat permintaan barang dan meminimalisir berbagai kesalahan yang bisa jadi muncul dalam proses bertransaksi keluar masuknya barang serta bagaimana proses input,output dalam pembuatan laporan yang dibutukan untuk menjadi lebih efektif dan efisien
URANIUM DETECTION ASSOCIATION IN PARAÍBA WITH THE INCIDENCE AND PREVALENCE OF CANCER
Authors: Sales Barros de Aguiar Michelle , Da Fonseca Julio de Macedo Nicole , Alves Bezerra Rebeca , Ester Silva Damasceno Jullyanne , Furtado de Carvalho Feitosa Sophia , Dos Santos Vilar Júlia , De Cássia Macêdo Correia Diniz Rita , Noêmia Carvalho da Silva Dayara , De Medeiros Amorim Marcela , Andrade Nóbrega Fernanda
Published: August 2024

The relationship between exposure to radioactive elements, such as uranium, and the increase in cancer incidence has been the subject of several scientific investigations. Previous studies indicate that prolonged exposure to ionizing radiation may be associated with an increased risk of development of malignant neoplasms. The objective of the present study was to analyze the association between cancer and mortality in Paraíba, especially in some municipalities, where there is uranium. The present work is an ecological study that analyzes the Uranium Association with Cancer. Systematic revisions constitute instruments of integrative analysis of available scientific information, allowing to obtain responses based on evidence to clinically relevant questions. The results show a very strong and positive correlation between these two variables, with a correlation coefficient of 0.989. This indicates that as the incidence of neoplasms in women increases, there is also an increase in mortality from external causes between women, and vice versa. Statistical significance (SIG.) For this correlation is 0.000, indicating that the correlation is highly significant, with a confidence level of 99%. The analysis of the association between cancer and mortality in Paraíba, with special focus in municipalities with the presence of Uranium has revealed significant insights on the possible impacts of uranium exposure on public health. The data obtained indicate a worrying correlation between the presence of uranium and the increase in the incidence of neoplasms and mortality, especially in mining areas and regions with high concentrations of natural radiation.