bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table S1 from Cell-Cycle Regulation Accounts for Variability in Ki-67 Expression Levels
Authors: Sobecki Michal , Mrouj Karim , Colinge Jacques , Gerbe François , Jay Philippe , Krasinska Liliana , Dulic Vjekoslav , Fisher Daniel
Published: April 2023

Dataset of high-confidence Ki-67 interactions
Supplementary Figure S1 from Autocrine BMP-4 Signaling Is a Therapeutic Target in Colorectal Cancer
Authors: Yokoyama Yuichiro , Watanabe Toshiaki , Tamura Yusuke , Hashizume Yoshinobu , Miyazono Kohei , Ehata Shogo
Published: April 2023

Regulation of BMP-4 by Wnt/ÃŸ-catenin pathway (related to Figure 2).
S-Figure-6 from Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma
Authors: Liu Yan , Li Yuyang , Wang Xiaoen , Liu Feiyang , Gao Peng , Quinn Max M. , Li Fei , Merlino Ashley A. , Benes Cyril , Liu Qingsong , Gray Nathanael S. , Wong Kwok-Kin
Published: April 2023

Pilot in vivo combination treatment studies of Kras/p53/Lkb1 lung tumors with AZD7762 and other drugs
Supplementary Figures 1 through 3 from Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment
Authors: Delitto Daniel , Delitto Andrea E. , DiVita Bayli B. , Pham Kien , Han Song , Hartlage Emily R. , Newby Brittney N. , Gerber Michael H. , Behrns Kevin E. , Moldawer Lyle L. , Thomas Ryan M. , George Thomas J. , Brusko Todd M. , Mathews Clayton E. , Liu Chen , Trevino Jose G. , Hughes Steven J. , Wallet Shannon M.
Published: April 2023

Supplemental Figure S1. Tumor-associated stromal response to pattern recognition receptor ligands. Supplementary Figure S2. Pancreatic cancer cell conditioned media and TLR4 ligation induces expression of antigen presentation machinery and negative co-stimulatory ligands on TAS. Supplemental Figure S3. TAS-mediated T cell suppression is enhanced by neutralization of either IL6 or IL8 and unaffected by TLR4 knockdown in TAS.
Figure S2 from Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination
Authors: Jiang Hong , Rivera-Molina Yisel , Gomez-Manzano Candelaria , Clise-Dwyer Karen , Bover Laura , Vence Luis M. , Yuan Ying , Lang Frederick F. , Toniatti Carlo , Hossain Mohammad B. , Fueyo Juan
Published: April 2023

Delta-24-RGDOX-induced necrosis (necr.) in the gliomas from C57BL/6 mice.
Supplementary Figure 2 from Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas
Authors: Dongre Anushka , Rashidian Mohammad , Reinhardt Ferenc , Bagnato Aaron , Keckesova Zuzana , Ploegh Hidde L. , Weinberg Robert A.
Published: April 2023

Supplementary Figure 2 shows immunosuppressive cells in tumors arising from Snail+ cells
Supplementary Figures from Adaptation to TKI Treatment Reactivates ERK Signaling in Tyrosine Kinase–Driven Leukemias and Other Malignancies
Authors: Bruner J. Kyle , Ma Hayley S. , Li Li , Qin Alice Can Ran , Rudek Michelle A. , Jones Richard J. , Levis Mark J. , Pratz Keith W. , Pratilas Christine A. , Small Donald
Published: April 2023

Figure S1: Sorafenib treatment induces phospho-ERK rebound in 32D/ITD cells. Figure S2: Further characterization of FLT3 inhibitor-mediated signaling adaptation. Figure S3: FLT3 signaling is maintained in low serum conditions. Figure S4: MEK inhibitor treatment abrogates phospho-ERK rebound. Figure S5: MEK inhibition synergizes with FLT3 inhibition to increase apoptosis in FLT3/ITD AML. Figure S6: NRAS mutant AML is sensitive to MEK inhibition but insensitive to the addition of sorafenib. Figure S7: MEK inhibition sensitizes K562 but does not sensitize PC9 or SKBR3 cells to RTK inhibition.
Supplemental Materials and Figure Legends from Arl13b Promotes Gastric Tumorigenesis by Regulating Smo Trafficking and Activation of the Hedgehog Signaling Pathway
Authors: Shao Jia , Xu Linlin , Chen Limin , Lu Quqin , Xie Xinsheng , Shi Wei , Xiong Huanting , Shi Chao , Huang Xuan , Mei Jinhong , Rao Hai , Lu Hua , Lu Nonghua , Luo Shiwen
Published: April 2023

This file contains "Supplemental Materials and Methods" and figure legends for "Supplemental Figures S1 to S8".
siRNA transfection, Table S1, Table S2 from MCPIP1 Downregulation in Clear Cell Renal Cell Carcinoma Promotes Vascularization and Metastatic Progression
Authors: Marona Paulina , Górka Judyta , Mazurek Zofia , Wilk Waclaw , Rys Janusz , Majka Marcin , Jura Jolanta , Miekus Katarzyna
Published: April 2023

Transient transfection with small interfering RNA (siRNA). Table 1. Sequences of primers Table 2. List of antibodies
CSC 2016 conference program from New Advances and Challenges of Targeting Cancer Stem Cells
Authors: Dashzeveg Nurmaa K. , Taftaf Rokana , Ramos Erika K. , Torre-Healy Luke , Chumakova Anastasia , Silver Daniel J. , Alban Tyler J. , Sinyuk Maksim , Thiagarajan Praveena S. , Jarrar Awad M. , Turaga Soumya M. , Saygin Caner , Mulkearns-Hubert Erin , Hitomi Masahiro , Rich Jeremy N. , Gerson Stanton L. , Lathia Justin D. , Liu Huiping
Published: April 2023

conference program
Cell line authentication SKN3 from A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers
Authors: Guo Theresa , Sakai Akihiro , Afsari Bahman , Considine Michael , Danilova Ludmila , Favorov Alexander V. , Yegnasubramanian Srinivasan , Kelley Dylan Z. , Flam Emily , Ha Patrick K. , Khan Zubair , Wheelan Sarah J. , Gutkind J. Silvio , Fertig Elana J. , Gaykalova Daria A. , Califano Joseph
Published: April 2023

Cell line authentication for SKN3
Figure S1 from PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma
Authors: Yoshino Hirofumi , Nohata Nijiro , Miyamoto Kazutaka , Yonemori Masaya , Sakaguchi Takashi , Sugita Satoshi , Itesako Toshihiko , Kofuji Satoshi , Nakagawa Masayuki , Dahiya Rajvir , Enokida Hideki
Published: April 2023

Strudctures
Table S1 from Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding
Authors: Lv Deguan , Jia Feng , Hou Yanli , Sang Youzhou , Alvarez Angel A. , Zhang Weiwei , Gao Wei-Qiang , Hu Bo , Cheng Shi-Yuan , Ge Jianwei , Li Yanxin , Feng Haizhong
Published: April 2023

Primer list.
Figure S1 from Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding
Authors: Lv Deguan , Jia Feng , Hou Yanli , Sang Youzhou , Alvarez Angel A. , Zhang Weiwei , Gao Wei-Qiang , Hu Bo , Cheng Shi-Yuan , Ge Jianwei , Li Yanxin , Feng Haizhong
Published: April 2023

qRT-PCR analysis of KAT6A mRNA expression.
Table S1 from ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage
Authors: Perkhofer Lukas , Schmitt Anna , Romero Carrasco Maria Carolina , Ihle Michaela , Hampp Stephanie , Ruess Dietrich Alexander , Hessmann Elisabeth , Russell Ronan , Lechel André , Azoitei Ninel , Lin Qiong , Liebau Stefan , Hohwieler Meike , Bohnenberger Hanibal , Lesina Marina , Algül Hana , Gieldon Laura , Schröck Evelin , Gaedcke Jochen , Wagner Martin , Wiesmüller Lisa , Sipos Bence , Seufferlein Thomas , Reinhardt Hans Christian , Frappart Pierre-Olivier , Kleger Alexander
Published: April 2023

DNA Repair gene set
Figure S1 from Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing Senescence
Authors: Bainor Anthony J. , Deng Fang-Ming , Wang Yu , Lee Peng , Cantor David J. , Logan Susan K. , David Gregory
Published: April 2023

Deletion of Sin3b does not impair loss of PTEN-driven AKT activation in the prostate anterior lobe. IHC stainings for SIN3B, PTEN, and pAKT of the anterior lobe of prostates taken from 3-month-old mice of each genotype.
Figure S1 from ETV1-Positive Cells Give Rise to BRAFV600E-Mutant Gastrointestinal Stromal Tumors
Authors: Ran Leili , Murphy Devan , Sher Jessica , Cao Zhen , Wang Shangqian , Walczak Edward , Guan Youxin , Xie Yuanyuan , Shukla Shipra , Zhan Yu , Antonescu Cristina R. , Chen Yu , Chi Ping
Published: April 2023

Long-term lineage tracing of the TAM-activated cre in ICCs using the Etv1CreERT2; Rosa26CAGGS-LSL-EYFP/+ lineage tracing system.
Supplementary tables from CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib
Authors: Sen Triparna , Tong Pan , Stewart C. Allison , Cristea Sandra , Valliani Aly , Shames David S. , Redwood Abena B. , Fan You Hong , Li Lerong , Glisson Bonnie S. , Minna John D. , Sage Julien , Gibbons Don L. , Piwnica-Worms Helen , Heymach John V. , Wang Jing , Byers Lauren Averett
Published: April 2023

This file contains supplementary tables Table S1: Genotypic status of human SCLC cell lines and their sensitivity to LY2606368 Table S2: Pairwise p-value of the syngeneic SCLC in vivo survival data of Figure 3 Table S3: Primers sequence for CHEK1 and GAPDH
Supplementary Information from Nuclear CD24 Drives Tumor Growth and Is Predictive of Poor Patient Prognosis
Authors: Duex Jason E. , Owens Charles , Chauca-Diaz Ana , Dancik Garrett M. , Vanderlinden Lauren A. , Ghosh Debashis , Leivo Mariah Z. , Hansel Donna E. , Theodorescu Dan
Published: April 2023

Methods, Supp Figure Legends, Supp Table Legend
Supplementary Figure and Figure Legends from CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib
Authors: Sen Triparna , Tong Pan , Stewart C. Allison , Cristea Sandra , Valliani Aly , Shames David S. , Redwood Abena B. , Fan You Hong , Li Lerong , Glisson Bonnie S. , Minna John D. , Sage Julien , Gibbons Don L. , Piwnica-Worms Helen , Heymach John V. , Wang Jing , Byers Lauren Averett
Published: April 2023

This file contains the supplementary figures and figure legends. Figure S1: CHK1 overexpression and LY2606368 targeting efficacy in SCLC. Figure S2:Combinatorial effect of LY2606368 and cisplatin. Figure S3: Anti-tumor efficacy of LY2606368. Figure S4: Effect of LY2606368 in platinum-resistant SCLC models. Figure S5: Combinatorial effect of LY2606368 and olaparib. Figure S6 and S7: Proteomic biomarkers of LY2606368 response. Figure S8: MYC expression predicts sensitivity to LY2606368.
Supp Figure 2 from Nuclear CD24 Drives Tumor Growth and Is Predictive of Poor Patient Prognosis
Authors: Duex Jason E. , Owens Charles , Chauca-Diaz Ana , Dancik Garrett M. , Vanderlinden Lauren A. , Ghosh Debashis , Leivo Mariah Z. , Hansel Donna E. , Theodorescu Dan
Published: April 2023

Additional cell lines and GFP-CD24 confirm effects of glutaraldehyde to fixation protocol and the nuclear CD24 signal.
Supplemental Fig. 2 from Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by Ex Vivo PI3K-δ Inhibition
Authors: Abu Eid Rasha , Ahmad Shamim , Lin Yuan , Webb Mason , Berrong Zuzana , Shrimali Rajeev , Kumai Takumi , Ananth Sudha , Rodriguez Paulo C. , Celis Esteban , Janik John , Mkrtichyan Mikayel , Khleif Samir N.
Published: April 2023

PI3K-delta inhibition preserves IL-2 production and does not affect cytotoxic cytokine secretion (all concentrations)
Supp Figure 1 from Nuclear CD24 Drives Tumor Growth and Is Predictive of Poor Patient Prognosis
Authors: Duex Jason E. , Owens Charles , Chauca-Diaz Ana , Dancik Garrett M. , Vanderlinden Lauren A. , Ghosh Debashis , Leivo Mariah Z. , Hansel Donna E. , Theodorescu Dan
Published: April 2023

Isolated surCD24- cells maintain loss of surCD24.
Figure S3 from Modeling Cytostatic and Cytotoxic Responses to New Treatment Regimens for Ovarian Cancer
Authors: Falcetta Francesca , Bizzaro Francesca , D'Agostini Elisa , Bani Maria Rosa , Giavazzi Raffaella , Ubezio Paolo
Published: April 2023

Comparison of the tumor growth curves of single-drug PTX and two-drugs DDP/PTX treatments with the expected curve for the DDP/PTX combination
Supplementary Information from Raman-Encoded Molecular Imaging with Topically Applied SERS Nanoparticles for Intraoperative Guidance of Lumpectomy
Authors: Wang Yu “Winston” , Reder Nicholas P. , Kang Soyoung , Glaser Adam K. , Yang Qian , Wall Matthew A. , Javid Sara H. , Dintzis Suzanne M. , Liu Jonathan T.C.
Published: April 2023

Supplementary Information (5 sections): Study design; Review of prior studies to validate the technical robustness of REMI; Selection of cell-surface biomarkers for REMI of breast tumors; Spectral demultiplexing to quantify SERS NPs; Cell culture and flow cytometry for the validation of conjugated NPs Supplementary Figures (10 figures): Supplementary Figure S1. Linearity and limit-of-detection of spectral measurements. Supplementary Figure S2. REMI of normal tissue (EGFR-negative) and tumor xenograſts (SkBr3, U251, and A431) that express various levels of EGFR. Supplementary Figure S3. Structure and spectra of SERS NPs. Supplementary Figure S4. Flow-cytometry based validation of the binding of targeted NPs to cell-surface receptors on cultured cells. Supplementary Figure S5. REMI enables the detection of double-positive breast tumor (ER+ and HER2+). Supplementary Figure S6. REMI enables the detection of EGFR in a triple-negative breast tumor. Supplementary Figure S7. REMI of fibroadenoma (benign lesion). Supplementary Figure S8. An illustration of a key difference between staining histological tissue sections and fresh tissue surfaces. Supplementary Figure S9. Comparison of traditional single-targeted-agent imaging vs. ratiometric imaging, in which an untargeted agent is used to normalize for the nonspecific accumulation that occurs for all agents. Supplementary Figure S10. Comparison of ROC curves for identification of biomarker expression using (A) a ratiometric imaging strategy (same as Fig. 5B) and (B) a traditional single-targeted-agent strategy. Supplementary Table S1. Benign lesions. Supplementary Table S2. Molecular profile of patients.
Supplementary Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Authors: Vandyke Kate , Zeissig Mara N. , Hewett Duncan R. , Martin Sally K. , Mrozik Krzysztof M. , Cheong Chee Man , Diamond Peter , To L. Bik , Gronthos Stan , Peet Daniel J. , Croucher Peter I. , Zannettino Andrew C.W.
Published: April 2023

Supplementary Figure Legends and Methods
Supp Figure 1 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Authors: Vandyke Kate , Zeissig Mara N. , Hewett Duncan R. , Martin Sally K. , Mrozik Krzysztof M. , Cheong Chee Man , Diamond Peter , To L. Bik , Gronthos Stan , Peet Daniel J. , Croucher Peter I. , Zannettino Andrew C.W.
Published: April 2023

Supp. Figure 1. Overexpression of HIF-2α and CXCL12 in the HMCLs LP-1 and RPMI-8226
Supplementary Figure 2 from Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine
Authors: Goto Norihiro , Ueo Taro , Fukuda Akihisa , Kawada Kenji , Sakai Yoshiharu , Miyoshi Hiroyuki , Taketo Makoto Mark , Chiba Tsutomu , Seno Hiroshi
Published: April 2023

Hes3 and Hes5 do not compensate for Hes1 deficiency in adult NSCs.
Supplemental table 2 from Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies
Authors: Bui Mai H. , Lin Xiaoyu , Albert Daniel H. , Li Leiming , Lam Lloyd T. , Faivre Emily J. , Warder Scott E. , Huang Xiaoli , Wilcox Denise , Donawho Cherrie K. , Sheppard George S. , Wang Le , Fidanze Steve , Pratt John K. , Liu Dachun , Hasvold Lisa , Uziel Tamar , Lu Xin , Kohlhapp Fred , Fang Guowei , Elmore Steven W. , Rosenberg Saul H. , McDaniel Keith F. , Kati Warren M. , Shen Yu
Published: April 2023

Anti-proliferative activity of MS417 across cancer cell lines
Figure S5 from Intestine-Specific Homeobox Gene ISX Integrates IL6 Signaling, Tryptophan Catabolism, and Immune Suppression
Authors: Wang Li-Ting , Chiou Shyh-Shin , Chai Chee-Yin , Hsi Edward , Yokoyama Kazunari K. , Wang Shen-Nien , Huang Shau-Ku , Hsu Shih-Hsien
Published: April 2023

Figure S5, A, Western blots analysis of IDOs, AHR, PD-L1 and CD86 protein expression in various hepatoma cells. CNL: Chang normal liver cells. B, The Kaplan-Meier survival curve analysis between HCC patients with low and high expression of CD80.
supplementary methods from JCAD Promotes Progression of Nonalcoholic Steatohepatitis to Liver Cancer by Inhibiting LATS2 Kinase Activity
Authors: Ye Juan , Li Tian-Sheng , Xu Gang , Zhao Yi-Ming , Zhang Ning-Ping , Fan Jia , Wu Jian
Published: April 2023

supplementary methods include Plasmids Generation of lentiviruses for JCAD knockdown and overexpression Genechip microarray analysis Total RNA extraction and cDNA synthesis Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR)Western blot analysis Immunoprecipitation Colony formation and spheroid formation assay il Red O staining and so on.
Supplementary Table 2 from MCAM Mediates Chemoresistance in Small-Cell Lung Cancer via the PI3K/AKT/SOX2 Signaling Pathway
Authors: Tripathi Satyendra C. , Fahrmann Johannes F. , Celiktas Muge , Aguilar Mitzi , Marini Kieren D. , Jolly Mohit K. , Katayama Hiroyuki , Wang Hong , Murage Eunice N. , Dennison Jennifer B. , Watkins D. Neil , Levine Herbert , Ostrin Edwin J. , Taguchi Ayumu , Hanash Samir M.
Published: April 2023

MassSpec counts for proteins identified with atleast two fold difference between H69AR and H69.
Supplementary Figures from Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells
Authors: Zarei Mahsa , Lal Shruti , Parker Seth J. , Nevler Avinoam , Vaziri-Gohar Ali , Dukleska Katerina , Mambelli-Lisboa Nicole C. , Moffat Cynthia , Blanco Fernando F. , Chand Saswati N. , Jimbo Masaya , Cozzitorto Joseph A. , Jiang Wei , Yeo Charles J. , Londin Eric R. , Seifert Erin L. , Metallo Christian M. , Brody Jonathan R. , Winter Jordan M.
Published: April 2023

Supplementary.Figures 1-8
Supplemental Figure Legends from Androgen Receptor Supports an Anchorage-Independent, Cancer Stem Cell-like Population in Triple-Negative Breast Cancer
Authors: Barton Valerie N. , Christenson Jessica L. , Gordon Michael A. , Greene Lisa I. , Rogers Thomas J. , Butterfield Kiel , Babbs Beatrice , Spoelstra Nicole S. , D'Amato Nicholas C. , Elias Anthony , Richer Jennifer K.
Published: April 2023

Supplemental Figure Legends
Supplemental Table 3 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Authors: Gao Yu , Li Hongzhao , Ma Xin , Fan Yang , Ni Dong , Zhang Yu , Huang Qingbo , Liu Kan , Li Xintao , Wang Lei , Gu Liangyou , Yao Yuanxin , Ai Qing , Du Qingshan , Song Erlin , Zhang Xu
Published: April 2023

Patients' clinical characteristics
Supplemental Table 1 from KLF6 Suppresses Metastasis of Clear Cell Renal Cell Carcinoma via Transcriptional Repression of E2F1
Authors: Gao Yu , Li Hongzhao , Ma Xin , Fan Yang , Ni Dong , Zhang Yu , Huang Qingbo , Liu Kan , Li Xintao , Wang Lei , Gu Liangyou , Yao Yuanxin , Ai Qing , Du Qingshan , Song Erlin , Zhang Xu
Published: April 2023

Antibodies and primers introduction
Table S2 from Immune-Related Gene Expression Profiling After PD-1 Blockade in Non–Small Cell Lung Carcinoma, Head and Neck Squamous Cell Carcinoma, and Melanoma
Authors: Prat Aleix , Navarro Alejandro , Paré Laia , Reguart Noemí , Galván Patricia , Pascual Tomás , Martínez Alex , Nuciforo Paolo , Comerma Laura , Alos Llucia , Pardo Nuria , Cedrés Susana , Fan Cheng , Parker Joel S. , Gaba Lydia , Victoria Iván , Viñolas Nuria , Vivancos Ana , Arance Ana , Felip Enriqueta
Published: April 2023

Anti-PD1 efficacy within each cancer-type.
Table S1 from Immune-Related Gene Expression Profiling After PD-1 Blockade in Non–Small Cell Lung Carcinoma, Head and Neck Squamous Cell Carcinoma, and Melanoma
Authors: Prat Aleix , Navarro Alejandro , Paré Laia , Reguart Noemí , Galván Patricia , Pascual Tomás , Martínez Alex , Nuciforo Paolo , Comerma Laura , Alos Llucia , Pardo Nuria , Cedrés Susana , Fan Cheng , Parker Joel S. , Gaba Lydia , Victoria Iván , Viñolas Nuria , Vivancos Ana , Arance Ana , Felip Enriqueta
Published: April 2023

Dataset of 65 tumor samples.
Figure S3 from Immune-Related Gene Expression Profiling After PD-1 Blockade in Non–Small Cell Lung Carcinoma, Head and Neck Squamous Cell Carcinoma, and Melanoma
Authors: Prat Aleix , Navarro Alejandro , Paré Laia , Reguart Noemí , Galván Patricia , Pascual Tomás , Martínez Alex , Nuciforo Paolo , Comerma Laura , Alos Llucia , Pardo Nuria , Cedrés Susana , Fan Cheng , Parker Joel S. , Gaba Lydia , Victoria Iván , Viñolas Nuria , Vivancos Ana , Arance Ana , Felip Enriqueta
Published: April 2023

Correlation between gene expression (y-axis) and percentages of stromal TILs (x-axis)
Figure S3 from Tumor-Associated Macrophages Promote Malignant Progression of Breast Phyllodes Tumors by Inducing Myofibroblast Differentiation
Authors: Nie Yan , Chen Jianing , Huang Di , Yao Yandan , Chen Jiewen , Ding Lin , Zeng Jiayi , Su Shicheng , Chao Xue , Su Fengxi , Yao Herui , Hu Hai , Song Erwei
Published: April 2023

Nuclear translocation of p65 is induced by CCL18 treatment.
Figure S2 from Tumor-Associated Macrophages Promote Malignant Progression of Breast Phyllodes Tumors by Inducing Myofibroblast Differentiation
Authors: Nie Yan , Chen Jianing , Huang Di , Yao Yandan , Chen Jiewen , Ding Lin , Zeng Jiayi , Su Shicheng , Chao Xue , Su Fengxi , Yao Herui , Hu Hai , Song Erwei
Published: April 2023

TAMs induce myoï¬�broblast differentiation and promote the growth and invasion of the PT cells via CCL18.
Figure S1 from Tumor-Associated Macrophages Promote Malignant Progression of Breast Phyllodes Tumors by Inducing Myofibroblast Differentiation
Authors: Nie Yan , Chen Jianing , Huang Di , Yao Yandan , Chen Jiewen , Ding Lin , Zeng Jiayi , Su Shicheng , Chao Xue , Su Fengxi , Yao Herui , Hu Hai , Song Erwei
Published: April 2023

CCL18 is mostly produced by TAMs in PTs and can be used as a diagnostic marker to distinguish aggressive from benign PTs.
Supplementary figure legends from Normal and Malignant Cells Exhibit Differential Responses to Calcium Electroporation
Authors: Frandsen Stine K. , Krüger Mie B. , Mangalanathan Uma M. , Tramm Trine , Mahmood Faisal , Novak Ivana , Gehl Julie
Published: April 2023

Legends for supplementary figures S1-S7: Figure S1. Image of PVDF membrane showing total protein content in normal and cancer cell lines; Figure S2. Light microscope image of colon cancer tumor treated with calcium electroporation; Figure S3. Tumor necrosis after treatment with different doses of calcium electroporation; Figure S4. Effect on skin above tumors treated with calcium electroporation; Figure S5. Effect on muscle below tumors treated with calcium electroporation; Figure S6. Effect on muscle tissue treated directly with calcium electroporation; Figure S7. Plasma membrane calcium ATPase (PMCA) mRNA level in normal and cancer cell lines.
Supplementary figures and methods from Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1
Authors: Si Yuan , Ji Xinyan , Cao Xiaolei , Dai Xiaoming , Xu Lingyi , Zhao Hongxia , Guo Xiaocan , Yan Huan , Zhang Haitao , Zhu Chu , Zhou Qi , Tang Mei , Xia Zongping , Li Li , Cong Yu-Sheng , Ye Sheng , Liang Tingbo , Feng Xin-Hua , Zhao Bin
Published: April 2023

This supplementary data file contains the detailed methods section and six figures. Figure S1 shows cell-matrix adhesion induces tyrosine phosphorylation of Lats1, and is related to Figure 1. Figure S2 shows Src phosphorylates Lats1/2, and is related to Figure 2. Figure S3 shows the effect of CSK on Lats1 tyrosine phosphorylation, and is related to Figure 3. Figure S4 shows the identification of Lats1 residues phosphorylated by Src, and is related to Figure 4. Figure S5 shows that Src activates YAP through inhibition of Lats1, and is related to Figure 5. Figure S6 provides essential controls to Figure 6.
Supplementary Table S3 from A Systematic Analysis of Oncogenic Gene Fusions in Primary Colon Cancer
Authors: Kloosterman Wigard P. , Coebergh van den Braak Robert R.J. , Pieterse Mark , van Roosmalen Markus J. , Sieuwerts Anieta M. , Stangl Christina , Brunekreef Ronne , Lalmahomed Zarina S. , Ooft Salo , van Galen Anne , Smid Marcel , Lefebvre Armel , Zwartkruis Fried , Martens John W.M. , Foekens John A. , Biermann Katharina , Koudijs Marco J. , Ijzermans Jan N.M. , Voest Emile E.
Published: April 2023

List of RNA-seq dataset identifiers from TCGA used for analyzing expression of ERAS and NTRK3 in colon and stomach cancer samples.
Supplemental Figure 6 from Tumor-Localized Secretion of Soluble PD1 Enhances Oncolytic Virotherapy
Authors: Bartee Mee Y. , Dunlap Katherine M. , Bartee Eric
Published: April 2023

Effects of immune subset depletion on the efficacy of vGFP therapy
Supplemental Figure 5 from Tumor-Localized Secretion of Soluble PD1 Enhances Oncolytic Virotherapy
Authors: Bartee Mee Y. , Dunlap Katherine M. , Bartee Eric
Published: April 2023

Immunological response of mice eradicated of B16/F10 tumors by vPD1
Supplementary Figures 1 through 5 from Chemopreventive Effects of ROS Targeting in a Murine Model of BRCA1-Deficient Breast Cancer
Authors: Li Mo , Chen Qian , Yu Xiaochun
Published: April 2023

Figure S1. The BBP mice develop breast cancer Figure S2. DNA damage occurs in mammary tumors of the BBP mice Figure S3. CHK1 activation is impaired in the absence of BRCA1 Figure S4. Recruitment of Rad51 is impaired in the absence of BRCA1. Figure S5. The effect of 4-OHE2 on virgin mice.
Supplementary Table 2, 3, and Figures from LSD1 Inhibitor T-3775440 Inhibits SCLC Cell Proliferation by Disrupting LSD1 Interactions with SNAG Domain Proteins INSM1 and GFI1B
Authors: Takagi Shinji , Ishikawa Yoshinori , Mizutani Akio , Iwasaki Shinji , Matsumoto Satoru , Kamada Yusuke , Nomura Toshiyuki , Nakamura Kazuhide
Published: April 2023

Supplementary Table 2: Genes commonly up-regulated or down-regulated by T-3775440 treatment in NCI-H1417, NCI-H510A, and NCI-526 cells. Supplementary Table 3: Plasma concentration and pharmacokinetic properties of T-3775440 in mice treated with a single dose of T-3775440 (30 mg/kg). Supplementary Figure 1: T-3775440 inhibits SCLC cell proliferation in a concentration-dependent manner. Supplementary Figure 2: INSM1 is strongly expressed in a subset of lung cancer cell lines. Supplementary Figure 3: INSM1 expression in AML (TF-1a and HEL), colon cancer (RKO), and SCLC cell lines (NCI-H510A, NCI-H526, and NCI-H1417). Supplementary Figure 4: SPR sensorgrams of the interaction of LSD1 with INSM1 peptide or GFI1B peptide. Supplementary Figure 5: Immunoblot analysis of siRNA-transfected cells. Supplementary Figure 6: ASCL1 and NeuroD1 are highly expressed in SCLC cells. Supplementary Figure 7: Microarray analysis of T-3775440-treated SCLC cells. Supplementary Figure 8: The PD markers KRT19, UMODL1, and VIM are upregulated in siINSM1-transfected NCI-H1417 cells. Supplementary Figure 9: Body weight changes in mice treated with T-3775440 or the vehicle control. Supplementary Figure 10: Plasma concentration of T-3775440 following a single oral dose of 30 mg/kg. Supplementary Figure 11: GFI1B expression in clinical SCLC samples.
Note S1 from Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer
Authors: Jin Lingyan , Garcia Jesse , Chan Emily , de la Cruz Cecile , Segal Ehud , Merchant Mark , Kharbanda Samir , Raisner Ryan , Haverty Peter M. , Modrusan Zora , Ly Justin , Choo Edna , Kaufman Susan , Beresini Maureen H. , Romero F. Anthony , Magnuson Steven , Gascoigne Karen E.
Published: April 2023

GNE-049 chemical synthesis
Figure S4 from Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer
Authors: Jin Lingyan , Garcia Jesse , Chan Emily , de la Cruz Cecile , Segal Ehud , Merchant Mark , Kharbanda Samir , Raisner Ryan , Haverty Peter M. , Modrusan Zora , Ly Justin , Choo Edna , Kaufman Susan , Beresini Maureen H. , Romero F. Anthony , Magnuson Steven , Gascoigne Karen E.
Published: April 2023

Western blot analysis of AR mutant and over expressing LNCaP cells
Supplemental Table S3 from Next-Generation Sequencing in the Clinical Setting Clarifies Patient Characteristics and Potential Actionability
Authors: Bieg-Bourne Cheyennedra C. , Millis Sherri Z. , Piccioni David E. , Fanta Paul T. , Goldberg Michael E. , Chmielecki Juliann , Parker Barbara A. , Kurzrock Razelle
Published: April 2023

Supplemental Table S3 displays the Foundation Medicine 323 gene panel for hematological malignancies.
Figure S1 from Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer
Authors: Jin Lingyan , Garcia Jesse , Chan Emily , de la Cruz Cecile , Segal Ehud , Merchant Mark , Kharbanda Samir , Raisner Ryan , Haverty Peter M. , Modrusan Zora , Ly Justin , Choo Edna , Kaufman Susan , Beresini Maureen H. , Romero F. Anthony , Magnuson Steven , Gascoigne Karen E.
Published: April 2023

Western blots confirming siRNA knockdowns, GNE-049 compound properties.
Supplemental Materials and Figures from Heme-oxygenase-1 Production by Intestinal CX3CR1+ Macrophages Helps to Resolve Inflammation and Prevents Carcinogenesis
Authors: Marelli Giulia , Erreni Marco , Anselmo Achille , Taverniti Valentina , Guglielmetti Simone , Mantovani Alberto , Allavena Paola
Published: April 2023

Table 1: Experimental procedures in mice Primers used in RT-PCRFigure S1: Colitis-associated carcinogenesis is more severe in CX3CR1GFP/GFP (KO mice) Figure S2: Macrophages from CX3CR1GFP/GFP mice are able to produce and sense IL10 Figure S3: CX3CR1 signaling induces STAT3 phosphorylation Figure S4: Sequencing of fecal microbiota of CX3CR1GFP/ (WT) and CX3CR1GFP/GFP (KO) mice (Figure S5: Effect of pharmacological treatments with the HMOX-1 inhibitor znPP (red) or the HMOX-1 stimulator coPP (blue) on the inflammation induced by 1 administration of DSS in WT mice Figure S6: Hematoxylin and eosin staining of CX3CR1GFP/ (WT) and CX3CR1GFP/GFP (KO) colon treated with coPP Figure S7: Double immunofluorescence on sections of adenomatous polyps from mice undergoing the AOM-DSS protocol
Table S1 from RNA Editing in Pathogenesis of Cancer
Authors: Baysal Bora E. , Sharma Shraddha , Hashemikhabir Seyedsasan , Janga Sarath Chandra
Published: April 2023

Levels of global A>I RNA editing in cancer
Supplementary Tables 1 and 2 from MET Exon 14 Mutation Encodes an Actionable Therapeutic Target in Lung Adenocarcinoma
Authors: Lu Xinyuan , Peled Nir , Greer John , Wu Wei , Choi Peter , Berger Alice H. , Wong Sergio , Jen Kuang-Yu , Seo Youngho , Hann Byron , Brooks Angela , Meyerson Matthew , Collisson Eric A.
Published: April 2023

Supplementary Tables 1 and 2
Supplementary Figure Legends from MET Exon 14 Mutation Encodes an Actionable Therapeutic Target in Lung Adenocarcinoma
Authors: Lu Xinyuan , Peled Nir , Greer John , Wu Wei , Choi Peter , Berger Alice H. , Wong Sergio , Jen Kuang-Yu , Seo Youngho , Hann Byron , Brooks Angela , Meyerson Matthew , Collisson Eric A.
Published: April 2023

Supplementary Figure Legends
Supplemental Figure S1 from PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1
Authors: Lacey Alexandra , Rodrigues-Hoffman Aline , Safe Stephen
Published: April 2023

Cell proliferation studies. (A) C2C12 cells were transfected with siNR4A1 or treated with 15 muM DIM-C-pPhCO2Me (24 hr), and effects on cell number were determined. (B) Rh30 and Rh18 cells were transfected with siCtl or siNR4A1 {plus minus} TGFβ (5 ng/ml) and cell numbers were counted. * Significantly (p<0.05) decreased.
Figs S8-S9 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Authors: Bakst Richard L. , Xiong Huizhong , Chen Chun-Hao , Deborde Sylvie , Lyubchik Anna , Zhou Yi , He Shizhi , McNamara William , Lee Sei-Young , Olson Oakley C. , Leiner Ingrid M. , Marcadis Andrea R. , Keith James W. , Al-Ahmadie Hikmat A. , Katabi Nora , Gil Ziv , Vakiani Efsevia , Joyce Johanna A. , Pamer Eric , Wong Richard J.
Published: April 2023

Cathepsin B loss impairs nerve invasion independent of tumor growth. Loss of this protease may keep the protective perineurium intact. This file contains two supplemental figures (S8 and S9).
Figs S10-S11 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Authors: Bakst Richard L. , Xiong Huizhong , Chen Chun-Hao , Deborde Sylvie , Lyubchik Anna , Zhou Yi , He Shizhi , McNamara William , Lee Sei-Young , Olson Oakley C. , Leiner Ingrid M. , Marcadis Andrea R. , Keith James W. , Al-Ahmadie Hikmat A. , Katabi Nora , Gil Ziv , Vakiani Efsevia , Joyce Johanna A. , Pamer Eric , Wong Richard J.
Published: April 2023

Analysis of human prostate cancer and adenoid cystic carcinoma specimens demonstrates macrophage infiltration around the majority of invaded nerves. This file contains two supplemental figures (S10-S11).
Fig S7 from Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression
Authors: Bakst Richard L. , Xiong Huizhong , Chen Chun-Hao , Deborde Sylvie , Lyubchik Anna , Zhou Yi , He Shizhi , McNamara William , Lee Sei-Young , Olson Oakley C. , Leiner Ingrid M. , Marcadis Andrea R. , Keith James W. , Al-Ahmadie Hikmat A. , Katabi Nora , Gil Ziv , Vakiani Efsevia , Joyce Johanna A. , Pamer Eric , Wong Richard J.
Published: April 2023

Anti-CCL2 treatment impairs IM recruitment and nerve invasion.
Supplementary Materials and Methods from Genetic Manipulation of Helicobacter pylori Virulence Function by Host Carcinogenic Phenotypes
Authors: Suarez Giovanni , Romero-Gallo Judith , Sierra Johanna C. , Piazuelo M. Blanca , Krishna Uma S. , Gomez Martin A. , Wilson Keith T. , Peek Richard M.
Published: April 2023

Detailed Materials and Methods
Supplementary Table-2 from The Blebbishield Emergency Program Overrides Chromosomal Instability and Phagocytosis Checkpoints in Cancer Stem Cells
Authors: Jinesh Goodwin G. , Kamat Ashish M.
Published: April 2023

Transcriptome differences between cancer cells and cancer cell-immune cell hybrid
Supplementary Movie 4 from The Blebbishield Emergency Program Overrides Chromosomal Instability and Phagocytosis Checkpoints in Cancer Stem Cells
Authors: Jinesh Goodwin G. , Kamat Ashish M.
Published: April 2023

Comparative time-lapse movie showing the differences in migratory behavior between RT4P cells and PBSHMS cells (See Fig. 3a for details on PBSHMS cells) to demonstrate that immune cell fusion enables migration. Freshly trypsinized RT4P and PBSHMS cells were subjected to time-lapse microscopy, which showed the increased migration of PBSHMS cells. The migratory cells with multinucleation were marked with orange arrows (See Fig. 3e right most panel).
Supplementary Movie 2 from The Blebbishield Emergency Program Overrides Chromosomal Instability and Phagocytosis Checkpoints in Cancer Stem Cells
Authors: Jinesh Goodwin G. , Kamat Ashish M.
Published: April 2023

Time-lapse movie showing the exit phase of blebbishield emergency program. Live RT4P cells were induced to undergo apoptosis and blebbishield formation and subjected to transformation (shown in the schematic of supplemental figure 1b on left). The transformation phase was subjected to time-lapse microscopy, which showed the exit phase, during which polarized cells emerged out of transformed spheres (orange arrows).
Supplementary Table S1. Identification of c-ABL-associated proteins from Cervical Cancer Growth Is Regulated by a c-ABL–PLK1 Signaling Axis
Authors: Yang Xu , Chen Gang , Li Wei , Peng Changmin , Zhu Yue , Yang Xiaoming , Li Teng , Cao Cheng , Pei Huadong
Published: April 2023

Tandem affinity purification was performed using HEK293 cells stably expressing FLAG-tagged c-ABL. The major hits from MS result were shown.
Supplementary Movie 1 from The Blebbishield Emergency Program Overrides Chromosomal Instability and Phagocytosis Checkpoints in Cancer Stem Cells
Authors: Jinesh Goodwin G. , Kamat Ashish M.
Published: April 2023

Time-lapse movie showing blebbishield formation from apoptotic bodies of an apoptotic cancer cell. Human RT4P bladder cancer cells were subjected to undergo apoptosis using BE medium pH adjusted to 6.5 with lactic acid (lactate enhances blebbishield formation), and the apoptotic cells were subjected to time-lapse imaging.
Supplementary Materials and Methods from Enriching the Housing Environment for Mice Enhances Their NK Cell Antitumor Immunity via Sympathetic Nerve–Dependent Regulation of NKG2D and CCR5
Authors: Song Yanfang , Gan Yu , Wang Qing , Meng Zihong , Li Guohua , Shen Yuling , Wu Yufeng , Li Peiying , Yao Ming , Gu Jianren , Tu Hong
Published: April 2023

Supplementary Materials and Methods.
Supporting Figures S1-S4 from Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer
Authors: Ponnusamy Suriyan , Coss Christopher C. , Thiyagarajan Thirumagal , Watts Kate , Hwang Dong-Jin , He Yali , Selth Luke A. , McEwan Iain J. , Duke Charles B. , Pagadala Jayaprakash , Singh Geetika , Wake Robert W. , Ledbetter Christopher , Tilley Wayne D. , Moldoveanu Tudor , Dalton James T. , Miller Duane D. , Narayanan Ramesh
Published: April 2023

S1: SARDs inhibit AR mutant activity. S2: UT-155-dependent degradation is selective to the AR. S3: UT-155 degrades wildtype and Y267 phospho mutant ARs. S4. UT-155 inhibits AR ABCD and AR-V7 induced activity.
Supplemental Table from Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer
Authors: Thomas Jeffrey D. , Longen Charles G. , Oyer Halley M. , Chen Nan , Maher Christina M. , Salvino Joseph M. , Kania Blase , Anderson Kelsey N. , Ostrander William F. , Knudsen Karen E. , Kim Felix J.
Published: April 2023

CT-189 Chemical, ADME, and Pharmacokinetics Properties.
Supplemental Figure S3 from Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases
Authors: Ross Michael H. , Esser Alison K. , Fox Gregory C. , Schmieder Anne H. , Yang Xiaoxia , Hu Grace , Pan Dipanjan , Su Xinming , Xu Yalin , Novack Deborah V. , Walsh Thomas , Colditz Graham A. , Lukaszewicz Gabriel H. , Cordell Elizabeth , Novack Joshua , Fitzpatrick James A. J. , Waning David L. , Mohammad Khalid S. , Guise Theresa A. , Lanza Gregory M. , Weilbaecher Katherine N.
Published: April 2023

Tumoral changes following TGF-­b stimulation and pharmacological inhibition of SMAD2/3
Supplemental Figure 2 from Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer
Authors: Thomas Jeffrey D. , Longen Charles G. , Oyer Halley M. , Chen Nan , Maher Christina M. , Salvino Joseph M. , Kania Blase , Anderson Kelsey N. , Ostrander William F. , Knudsen Karen E. , Kim Felix J.
Published: April 2023

Quantification of immunoblot band densities in Figure 3B.
Supplemental Figure S1 from Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases
Authors: Ross Michael H. , Esser Alison K. , Fox Gregory C. , Schmieder Anne H. , Yang Xiaoxia , Hu Grace , Pan Dipanjan , Su Xinming , Xu Yalin , Novack Deborah V. , Walsh Thomas , Colditz Graham A. , Lukaszewicz Gabriel H. , Cordell Elizabeth , Novack Joshua , Fitzpatrick James A. J. , Waning David L. , Mohammad Khalid S. , Guise Theresa A. , Lanza Gregory M. , Weilbaecher Katherine N.
Published: April 2023

Immunohistochemistry and flow cytometry of tumor cells for integrin expression
Supplementary Figure Legends from Krüppel-like Transcription Factor KLF10 Suppresses TGFβ-Induced Epithelial-to-Mesenchymal Transition via a Negative Feedback Mechanism
Authors: Mishra Vivek Kumar , Subramaniam Malayannan , Kari Vijayalakshmi , Pitel Kevin S. , Baumgart Simon J. , Naylor Ryan M. , Nagarajan Sankari , Wegwitz Florian , Ellenrieder Volker , Hawse John R. , Johnsen Steven A.
Published: April 2023

Description of Supplementary Figures 1-3
Supplemental Table from Krüppel-like Transcription Factor KLF10 Suppresses TGFβ-Induced Epithelial-to-Mesenchymal Transition via a Negative Feedback Mechanism
Authors: Mishra Vivek Kumar , Subramaniam Malayannan , Kari Vijayalakshmi , Pitel Kevin S. , Baumgart Simon J. , Naylor Ryan M. , Nagarajan Sankari , Wegwitz Florian , Ellenrieder Volker , Hawse John R. , Johnsen Steven A.
Published: April 2023

Supplemental table S1 Primers for gene expression and ChIP analysis (5'-3' orientation)
Supplementray Table S1 from Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells
Authors: Tong Jingshan , Wang Peng , Tan Shuai , Chen Dongshi , Nikolovska-Coleska Zaneta , Zou Fangdong , Yu Jian , Zhang Lin
Published: April 2023

Table S1. Sequences of PCR primers used for vector construction and PCR screening of Mcl-1-KI cell lines, and for analysis of Mcl-1 mRNA expression.
Supplementary Figure S1-S3 from Mcl-1 Degradation Is Required for Targeted Therapeutics to Eradicate Colon Cancer Cells
Authors: Tong Jingshan , Wang Peng , Tan Shuai , Chen Dongshi , Nikolovska-Coleska Zaneta , Zou Fangdong , Yu Jian , Zhang Lin
Published: April 2023

Figure S1. Regorafenib and sorafenib did not affect Mcl-1 mRNA expression but induced GSK3β-dependent Mcl-1 degradation. A transfected quadruple mutant in 4 putative phosphorylation sites (S121A/E125A/S159A/T163A) of Mcl-1 was resistant to regorafenib-induced ubiquitination and degradation. Figure S2. Apoptosis induced by regorafenib or sorafenib was suppressed in HCT116 cells with Mcl-1 phosphorylation site mutant knock-in (Mcl-1-KI), inhibition of GSK3β, or knockout of BAX. Figure S3. Mcl-1 degradation and PUMA induction did not affect each other in regorafenib-induced apoptosis. Regorafenib-induced apoptosis in Mcl-1-KI cells could not be restored by the Bcl-2/Bcl-XL inhibitors ABT-737 or ABT-263.
Supplementary Figure S2. HuR binds and stabilizes PARG mRNA from Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors
Authors: Chand Saswati N. , Zarei Mahsa , Schiewer Matthew J. , Kamath Akshay R. , Romeo Carmella , Lal Shruti , Cozzitorto Joseph A. , Nevler Avinoam , Scolaro Laura , Londin Eric , Jiang Wei , Meisner-Kober Nicole , Pishvaian Michael J. , Knudsen Karen E. , Yeo Charles J. , Pascal John M. , Winter Jordan M. , Brody Jonathan R.
Published: April 2023

HuR directly binds and regulates poly-ADP ribose glycohydrolase mRNA expression particularly under PARPi stress, but doesn't affect expression of other PAR polymerases or hydrolyzing enzymes.
Supplementary Table 5 from ATR Is a Therapeutic Target in Synovial Sarcoma
Authors: Jones Samuel E. , Fleuren Emmy D.G. , Frankum Jessica , Konde Asha , Williamson Chris T. , Krastev Dragomir B. , Pemberton Helen N. , Campbell James , Gulati Aditi , Elliott Richard , Menon Malini , Selfe Joanna L. , Brough Rachel , Pettitt Stephen J. , Niedzwiedz Wojciech , van der Graaf Winette T.A. , Shipley Janet , Ashworth Alan , Lord Christopher J.
Published: April 2023

This file lists the siRNAs that are significantly associated with VX-970 resistance in SYO1 SS tumour cells in which siRNA effects in VX970-exposed vs. DMSO-exposed cells were compared, quantifying resistance-causing effects as Drug Effect (DE) Z-scores. Genes are ranked according to DE Z-scores.
Supplementary Figure S3. from FGF19 Protects Hepatocellular Carcinoma Cells against Endoplasmic Reticulum Stress via Activation of FGFR4–GSK3β–Nrf2 Signaling
Authors: Teng Yong , Zhao Huakan , Gao Lixia , Zhang Wenfa , Shull Austin Y. , Shay Chloe
Published: April 2023

An electrochemical detection method was developed to examine the ability of removing superoxide free radical (O2Ã¢â,¬â¢-) on electrochemical station. Cx represents certain current in peak (potential=0.7V), C0 represents control current in peak (potential=0.7V), and the current changes % = (Cx-C0)/C0Ãƒâ€"100%.
Supplementary Figure S2. from FGF19 Protects Hepatocellular Carcinoma Cells against Endoplasmic Reticulum Stress via Activation of FGFR4–GSK3β–Nrf2 Signaling
Authors: Teng Yong , Zhao Huakan , Gao Lixia , Zhang Wenfa , Shull Austin Y. , Shay Chloe
Published: April 2023

Gene expression data of FGF19, ATF4, HO-1 and Bcl-2 were obtained from GEO dataset GSE36756 (433 HCC tissue samples) and GSE5975 (238 HCC tissue samples). The scatter plot shows the correlation of gene expression.
Supplementary Figure S1. from FGF19 Protects Hepatocellular Carcinoma Cells against Endoplasmic Reticulum Stress via Activation of FGFR4–GSK3β–Nrf2 Signaling
Authors: Teng Yong , Zhao Huakan , Gao Lixia , Zhang Wenfa , Shull Austin Y. , Shay Chloe
Published: April 2023

Real-time RT-PCR analysis shows that ER stress marker Grp78 is significantly increased in mouse liver when treated with vehicle, TG (1 mg/kg, i.p., 12 h), CCl4 (0.6 ml/kg, i.p., 12 h) or Acetaminophen (500 mg/kg, i.p., 6 h), respectively (n=3). While no Fgf15 mRNA can be detected in the mouse liver in any of these treatments. *P<0.05, **P<0.01.
Supplementary Table 2 from ATR Is a Therapeutic Target in Synovial Sarcoma
Authors: Jones Samuel E. , Fleuren Emmy D.G. , Frankum Jessica , Konde Asha , Williamson Chris T. , Krastev Dragomir B. , Pemberton Helen N. , Campbell James , Gulati Aditi , Elliott Richard , Menon Malini , Selfe Joanna L. , Brough Rachel , Pettitt Stephen J. , Niedzwiedz Wojciech , van der Graaf Winette T.A. , Shipley Janet , Ashworth Alan , Lord Christopher J.
Published: April 2023

This file contains the list of the 79 small molecule inhibitors currently used or in the late stages of clinical development for cancer treatment, that were included in our drug screen.
Supplementary Figures from ATR Is a Therapeutic Target in Synovial Sarcoma
Authors: Jones Samuel E. , Fleuren Emmy D.G. , Frankum Jessica , Konde Asha , Williamson Chris T. , Krastev Dragomir B. , Pemberton Helen N. , Campbell James , Gulati Aditi , Elliott Richard , Menon Malini , Selfe Joanna L. , Brough Rachel , Pettitt Stephen J. , Niedzwiedz Wojciech , van der Graaf Winette T.A. , Shipley Janet , Ashworth Alan , Lord Christopher J.
Published: April 2023

This file contains the following supplementary data: Supplementary Figure 1. Detailed information on the effects of siATR and VX970 in SS tumour cell lines and additional tumour and non-tumour cell lines; Supplementary Figure 2. Effects of SS18-SSX fusion expression, and ARID1A or SMARCB1 knockdown on viability and VX970 sensitivity of non-SS cell lines; Supplementary Figure 3. Ability of SS tumour cells to elicit ATR signalling in response to either cisplatin or hydroxyurea, or ATM signalling in response to ionising radiation (IR), and SS tumour cell sensitivity to PARP inhibitors; Supplementary Figure 4. DNA fibre analysis illustrating replication fork speed in SYO-1 SS tumour cells upon VX970 exposure, and additional figures relating to the link between VX970 resistance and CCNE1; Supplementary Figure 5. Combination of VX970 to standard-of-care agents used in SS.
Figure S3 from Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody–Drug Conjugates
Authors: Caculitan Niña G. , dela Cruz Chuh Josefa , Ma Yong , Zhang Donglu , Kozak Katherine R. , Liu Yichin , Pillow Thomas H. , Sadowsky Jack , Cheung Tommy K. , Phung Qui , Haley Benjamin , Lee Byoung-Chul , Akita Robert W. , Sliwkowski Mark X. , Polson Andrew G.
Published: April 2023

Supplementary Figure 3: Effect of pharmacological inhibition of cathepsin B in KPL-4 cells. A) Loss of enzymatic activity with the addition of CA074-ME. B) Dose-titration curve for KPL-4 cells with and without CA074-ME in the presence of anti-HER2-VC(S)-MMAE. C) Free MMAE release in KPL-4 cells with and without CA074-ME.
Figure S2 from Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody–Drug Conjugates
Authors: Caculitan Niña G. , dela Cruz Chuh Josefa , Ma Yong , Zhang Donglu , Kozak Katherine R. , Liu Yichin , Pillow Thomas H. , Sadowsky Jack , Cheung Tommy K. , Phung Qui , Haley Benjamin , Lee Byoung-Chul , Akita Robert W. , Sliwkowski Mark X. , Polson Andrew G.
Published: April 2023

Supplementary Figure 2: Dose titration curves for BT-474M1 parental and CTSB deleted cells (A) and BJAB parental and cathepsin B knockdown cells exposed to mAb-VC(S)-MMAE.
Video 1 from TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells
Authors: Li Taiwen , Fan Jingyu , Wang Binbin , Traugh Nicole , Chen Qianming , Liu Jun S. , Li Bo , Liu X. Shirley
Published: April 2023

Video 1