bluuebunny/crossref_metadata_2025 huggingface dataset:
Discovering the anti-parasitic activity of melatonin loaded lecithin/chitosan nanoparticles against giardiasis and cryptosporidiosis in Balb/c infected mice
Authors: Nasser Mohamed , El-atif Mona B. Abd , Alaa Habiba , Abdelaziz Mariam , Mustafa Mariam , Masour Mustafa , Magdy Salma , Mohsen Salma , El Karamany Yomna , Farid Alyaa
Published: February 2025

Background

Giardia duodenalis and Cryptosporidium parvum are the primary causes of diarrhea with global attention due to the severe pathophysiological changes leading to mortality. During this study, we explored the biological protozoal contaminants (Giardia and Cryptosporidium spp.) in some areas of the Nile River. Then, we evaluated effectiveness of melatonin (Mel) and melatonin loaded lecithin/chitosan nanoparticles (Mel-LCNPs) against giardiasis and cryptosporidiosis in mice models using parasitological and inflammatory response examination.

Results

The number of positive samples for Cryptosporidium was higher than that for Giardia with percentage of 46.67% and 40.0%, respectively. Prior to treatment, the physical characterization (hydrodynamic size and zeta potential) and in vitro characterization of Mel-LCNPs were carried. Mel-LCNPs revealed a hydrodynamic size of 78.8 nm and a zeta potential of − 27.2 mV. Furthermore, they have powerful antioxidant and anti-inflammatory properties, while displaying minimal anticoagulant and cytotoxic effects during in vivo evaluation. Mel was consistently discharged from nanoparticles in a regulated and enduring manner for 36 h. Moreover, Mel in NPs has an entrapment efficiency (EE) of 33.6% and a drug loading capacity (DLC) of 7.2% and significant reduction (100% and 99.4%, respectively) in the shedding of Giardia cysts and Cryptosporidium oocysts. This reduction was higher than that observed with Mel alone or LCNPs alone on the 14th day post-infection. Moreover, mice of group V, which received Mel-LCNP treatment, exhibited significantly normal levels of interleukin-4 (IL-4) and interferon-gamma (IFN-γ) as well as healthy control mice group (group I).

Conclusion

Mel-LCNPs were highly effective preparations against giardiasis and cryptosporidiosis in Balb/c mice experimentally infected with proved antioxidant, anti-inflammatory, and immunological modulatory characteristics.
Blue applicability grade index assessment and response surface modelling to synchronous determination of metformin hydrochloride, vildagliptin and dapagliflozin propanediol monohydrate by HPTLC method
Authors: Prajapati Pintu , Patil Krutika , Naik Dhrumi , Pulusu Veera Shakar , Haque Anzarul , Kalam Mohd Abul , Shah Shailesh
Published: February 2025

Diabetes mellitus is major chronic disease found in human due to stressful lifestyle and bad food habit. Recently, the Central Drugs Standard Control Organization of India has approved combination of metformin hydrochloride, vildagliptin and dapagliflozin propanediol monohydrate for the management of diabetes mellitus. Numerous chromatographic methods have been published in the literature for estimation of these anti-diabetic drugs on individual basis and their combinations. But these chromatographic analyses promoted usage of toxic organic solvents which are harmful to the environment and aquatic animal lives. In addition, no chromatographic method was found in the literature for simultaneous estimation of these anti-diabetic drugs using green solvents. In recent days, white analytical chemistry approach has been introduced in the literature for development and assessment of green, accurate, precise, cost-effective and user-friendly chromatographic methods. Hence, white analytical chemistry-driven risk-based HPTLC method was developed for synchronous estimation of these anti-diabetic drugs using green solvents and response surface modelling. The analytical quality risk assessment was applied for identification of critical method variables and response variables using risk priority number ranking and filtering method. The critical method variables were linked with critical response variables using response surface modelling by Box–Behnken design. The analytical design space was navigated control strategy was framed for robust densitometric estimation of anti-diabetic drugs. The chromatographic method was validated as per ICH Q2 (R2) guideline. The developed method was applied for synchronous assay of multiple combinations of metformin, vildagliptin and dapagliflozin using single chromatographic condition to save time, cost and resources for analysis. The assay results of these anti-diabetic drug combinations were found to be complied with the respective labelled claim of the drugs. The developed and published chromatographic methods were assessed for their redness, greenness, blueness and whiteness profiles using green analytical metrics and RGB model scoring system. The proposed method was found to be green, cost-effective, robust and user-friendly for synchronous estimation of metformin, vildagliptin and dapagliflozin.
Lower serum magnesium level is an important risk factor for erythropoiesis-stimulating agents hypo-responsiveness in hemodialysis patients
Authors: Hebah Hayam , Abdelmegied Shaimaa , Osman Dina , Khedr Lina
Published: February 2025

Purpose

There is an established inverse association between serum magnesium levels and anemia in the general population. However, limited information is available about this association in patients on hemodialysis. This study investigated the relationship between serum magnesium and anemia in prevalent hemodialysis patients and its relation to erythropoiesis-stimulating agents (ESAs) hyporesponsiveness.

Methods

A cross-sectional observational study included 80 prevalent hemodialysis patients. Laboratory data were measured over 3 months. Study populations were divided into 2 groups; group A (n = 34) with serum Mg ≤ 2.2 mg/dl and group B (n = 46) with serum Mg > 2.2 mg/dl. The erythropoietin resistivity index (ERI) was calculated for all patients.

Results

There were significantly lower mean hemoglobin levels in patients with normo-hypomagnesemia vs patients with hypermagnesemia (8.96 ± 0.44 Vs 9.51 ± 0.39 g/dl respectively), with a p-value < 0.001. ERI mean values were (13.63 ± 3.17 Vs 10.52 ± 2.74 IU/week/kg) which was also found to be a significant p-value < 0.001. Patients with normo-hypomagnesemia had more dialysis-associated symptoms (tremors, weakness, and muscle cramps) (p-value < 0.001). Low serum magnesium was positively correlated with hemoglobin and transferrin saturation (p-value 0.019, 0.001) respectively while it negatively correlated with PTH and ERI (p-value < 0.001, 0.001) respectively. Multivariate analysis revealed that low serum magnesium has been an independent risk for ERI 5 times with odds ratio (OR = 5.159 and p-value < 0.001).

Conclusion

Lower serum magnesemia is an important risk factor for ESAs hypo-responsiveness with more dialysis-associated symptoms.
Modeling of masonry infilled RC frames with different aspect ratios using plastic hinge and equivalent strut
Authors: El-Kholy Ahmed M. , Sayed Sayed M. , El-Assaly Mohamed M. , Ismail Mohamed K.
Published: February 2025

The existence of diverse modeling approaches for masonry-infilled frames causes uncertainty among practicing engineers when seeking a definitive model for their design practice. This paper presents a practical and simple approach to modeling the masonry-infilled frames. The proposed approach models the plasticity in the beams and columns of the reinforced concrete (RC) frames using flexural plastic hinges while modeling the masonry panel as a nonlinear equivalent strut. The implementation of the hinge is based on discretizing the frame cross-section into fibers and utilizing a popular formula to estimate the plastic hinge length specific to masonry-infilled frames. Furthermore, the implemented equivalent strut model employs a trilinear force–displacement backbone curve. The efficiency of this approach was evaluated against the experimental results of four different tested infilled RC frames available in the literature. A conventional approach based on a typical explicit plastic hinge was included for comparison. Unlike the conventional approach, the numerical results obtained from the presented approach better matched the experimental results. Subsequently, the presented approach was utilized to investigate the effect of the aspect ratio of clay masonry infill panels on the behavior of RC frames. The investigation revealed that the panels with larger aspect ratios provided a larger contribution to the ultimate lateral load, despite experiencing lower ultimate axial stresses compared to panels with smaller aspect ratios. However, increasing the thickness of the masonry infill with a small aspect ratio appeared to improve its effectiveness in resisting the lateral force.
A stage IIIA lung adenocarcinoma case achieving pathological response with only one cycle of preoperative nivolumab combination chemotherapy
Authors: Baba Shuhei , Kinoshita Fumihiko , Yamamoto Yoshihiro , Nakanishi Yoshiyuki , Akamine Takaki , Kohno Mikihiro , Ozono Keigo , Takenaka Tomoyoshi , Yoshizumi Tomoharu
Published: February 2025

Background

Preoperative nivolumab combination chemotherapy has shown its efficacy in resectable stage II–III non-small cell lung cancer and become one of the standard treatments. While preoperative nivolumab combination chemotherapy is generally a regimen of three cycles, the efficacy of nivolumab combination chemotherapy when treatment is prematurely discontinued remains unclear.

Case presentation

An 81-year-old man was diagnosed as lung adenocarcinoma (cT3N1M0, cStage IIIA). A computed tomography (CT) showed a 58 mm mass in left upper lobe with an intrapulmonary metastasis, and a positron-emission tomography/CT suggested metastatic lymph nodes at the left pulmonary hilum. Preoperative nivolumab + carboplatin + paclitaxel were administered; however, after the first cycle, the treatment was discontinued due to grade 3 anorexia, grade 1 body weight loss, and grade 4 neutropenia. It was affair that continuation of preoperative therapy made him unsuitable for surgery, and CT scan showed a reduction in the tumor size to 20 mm. Then, we decided to discontinue the preoperative therapy and perform surgery. Video-assisted thoracoscopic left upper lobectomy and lymph node dissection were performed, and the postoperative course was uneventful. The pathological examination revealed 15% of residual tumor cell in primary lesion and no metastatic lymph nodes was diagnosed. The patient did not undergo adjuvant chemotherapy, and no recurrence was observed 1.5 years after surgery

Conclusions

In this case, preoperative nivolumab combined chemotherapy was discontinued only one cycle due to adverse events; however, a significant treatment effect was achieved. Therefore, even it is unable to continue preoperative nivolumab combined therapy, it is important not to miss the chance of surgery, as good treatment effect may have been achieved.
Reproductive state-dependent cell turnover in the inner ear of the plainfin midshipman fish (Porichthys notatus)
Authors: Jasper Coty W. , Molano Olivia , Fearington Forrest , Sisneros Joseph A. , Coffin Allison B.
Published: February 2025

Plainfin midshipman fish (Porichthys notatus) exhibit seasonal auditory plasticity that likely enhances their reproductive success. During the summer, type I (TI) male midshipman acoustically court females and both TI males and females exhibit increased auditory sensitivity during this period. The enhanced auditory sensitivity is associated with increased density of sensory hair cells in the saccule but not the utricle, suggesting that different mechanisms underlie physiological plasticity in distinct inner ear regions. To better understand how shifts in hair cell number occur within auditory tissues, we examined cell turnover across breeding states and sexes in midshipman fish. We found that reproductive TI males exhibited less saccular cell proliferation than non-reproductive males without a change in cell death, indicating a net loss of saccular cells during the breeding season. By contrast, saccular cell proliferation increased in summer females, with no seasonal changes in other inner ear epithelia. Collectively, our data reveal that multiple mechanisms likely contribute to seasonal auditory plasticity within a single species, potentially within the ear of an individual animal.
Workforce Diversity in Sports Medicine: Analysis of Recent Trends Relative to the US Population
Authors: Silvestre Jason , Kelly John D. , Slone Harris S.
Published: February 2025

This was a cross-sectional study of sports medicine fellows from previous (2010–2015) and contemporary (2016–2021) training periods. There were 2315 trainees from family medicine (FM, 85%), 261 trainees from physical medicine and rehabilitation (PMR, 10%), and 133 trainees from emergency medicine (EM, 5%). PMR had the highest female and Asian trainee representation while FM had the highest Black trainee representation. There was no difference in female representation between training periods (30% vs 30%, P = 0.714). White trainee representation decreased between training periods (72% vs 65%, P < 0.001). Black (6% vs 6%, P = 0.894), Asian (15% vs 15%, P = 0.970), and Hispanic (6% vs 7%, P = 0.130) trainee representation was consistent between training periods. Female (participation-to-prevalence ratio, PPR = 0.59), Black (PPR = 0.48), Hispanic (PPR = 0.35), and American Indian/Alaskan Native (PPR = 0.17) trainees were underrepresented in sports medicine relative to the US population. Efforts to recruit underrepresented groups in sports medicine fellowship training may help create a more diverse workforce.
The genome sequence of the Grey Arches moth, Polia nebulosa Hufnagel, 1766
Authors: Griffiths Andy , Prescott Tom , Forrester Ronald ,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: February 2025

We present a genome assembly from an individual male specimen of Polia nebulosa (Grey Arches; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence has a total length of 1,011.20 megabases. Most of the primary assembly (99.27%) is scaffolded into 30 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 15.39 kilobases in length.
From GIA to the Islamic State (IS): De-radicalization as countering violent extremism strategy in Algeria
Authors: SOUR Lotfi
Published: February 2025

Terrorism is not new to Algeria, it had a long history, which dating back to the early 80'. In fact, Islamic extremism in Algeria have indeed existed before the cancellation of the electoral process at the beginning of 1992. Following a series of deadly domestic terrorist attacks in 1990s, the Algerian government started developing robust counterterrorism and deradicalization methods comprising both military and non-military measures (commonly known as hard and soft approaches), to de-radicalize terrorists and insurgents across the country. Besides traditional security, military, and law-enforcement attempts to capture, jail, or eliminate terrorists, the Algerian government also launched a parallel strategy to combat the ideological justifications for violent radicalism and extremism within Algeria including a truce, a reconciliation process, demobilization, rehabilitation and reintegration programs by engaging non-state actors such as civil society, and zawiyyas, as well as investing in development. Today, Algeria, with its combination of a soft and hard approach, provides a successful example of how to neutralize terrorism after having defeated various terrorist groups between 1993 and 2003 and overseen a transition from civil war to peace since then.
This paper outlines the Algerian government’s attempts, approaches, and initiatives on combating terrorism and de-radicalization as well as analyzes their strengths and limitations. It sketches how the Algerian government, especially since mid-90', dealt, engaged, overcame, and resolves issues and problems of terrorism and extremism. The purpose of the paper is present facts and information about the Algerian experience at fighting terrorism and Algeria's long struggle in the combat of extremist and terrorist threats. The paper also assesses and analyzes the effectiveness and ineffectiveness, strengths, and weaknesses of the Algerian successive governments policies and approaches of counterterrorism.
African Solutions to African Problems
Authors: Pongrácz Bálint
Published: February 2025

Eeben Barlow's third book, "The War for Africa, Conflict, Crime, Corruption & Foreign Interest" gives a personal, often witty yet indisputably forthright insight into the secretive world of private military contractors in Africa. Incorporating a number of venturous endeavours in no less than ten countries of the continent, it is an accessible and entertaining read for the general public. Additionally, for academics and policymakers, the book provides a unique local perspective on the contemporary African security environment.
“It’s a given now, that’s just how we communicate”: Pregnant people’s experiences with using communication technology when connecting with their midwife
Authors: Wakelin Karen , McAra-Couper Judith , Fleming Tania
Published: February 2025

Introduction: Effective communication between pregnant women/people and midwives is important in establishing trusting and respectful relationships. Texting and email have been shown to be convenient ways for people to connect and share information.
Aim: This paper reports on findings from interviews with pregnant and recently pregnant women/people on what is important for them when using communication technology to connect with their midwife.
Method: Semi-structured interviews were conducted using an online platform. Two participants had previously completed an online survey in phase 1B of the multi-phase study and had expressed interest in participating further. Three other participants were recruited via a closed Pregnancy Facebook group and midwives. All participants were emailed an invitation to participate. Thematic analysis was used to analyse the interview data.
Findings: Three themes emerged from the findings, highlighting what was important for participants when using communication technology with their midwife during their pregnancy: being known, access and connectedness, and the midwife recognised as a professional.
Discussion: Being known was important when using communication technology, as it enabled respectful and trusting relationships to develop. These relationships were further enhanced through the functionality of communication technology which provided space for participants to compose messages and respond to their midwife, and through the convenience and flexibility with being able to communicate in a non-intrusive manner. The professionalism of the midwife was recognised with ensuring privacy of information, despite participants being unconcerned about privacy themselves.
Conclusion: The knowingness that comes from a continuity of care relationship contributed towards a relationship of trust. This was reflected in the respectful choices made by the participants when using communication technology to connect with their midwife.
Percepciones sobre el rol del tutor sombra en el aprendizaje de idiomas de estudiantes con Condición del Espectro Autista (CEA).
Authors: Briceño Nuñez Chess Emmanuel
Published: February 2025

Este estudio se centra en el papel del
tutor sombra en el aprendizaje de idiomas para
estudiantes con Condición del Espectro Autista
(CEA), donde un tutor sombra es un profesional
que brinda apoyo individualizado a estos
estudiantes. La investigación aborda la
importancia de esta figura en el contexto de
docentes de idiomas debido a la creciente
necesidad de inclusión de estudiantes con CEA
en aulas regulares de idiomas. Para abordar
esta cuestión, se utilizó una metodología mixta
(cuali-cuantitativa) con un diseño transversal. Se
encuestaron 100 docentes de idiomas que
trabajaron durante el año escolar 2020-2021,
para la selección de la muestra se consideraron
aspectos como sexo, edad, nacionalidad, nivel
escolar en el que enseñaban y los idiomas
impartidos. El instrumento empleado fue el
"Cuestionario de Evaluación del Rol del Tutor
Sombra en el Aprendizaje de Idiomas". Los
resultados revelaron que la presencia de un tutor
sombra es fundamental para facilitar el
aprendizaje de estudiantes con CEA, con una
mejora significativa en la comunicación y
habilidades lingüísticas. Este resultado crucial
destaca la importancia de capacitar a los tutores
sombra y docentes para brindar una educación inclusiva y equitativa. Se debe trabajar en una
comprensión más profunda de la CEA y las
necesidades específicas de los estudiantes que
la padecen. Futuras investigaciones pueden
enfocarse en estrategias de capacitación para
tutores sombra y docentes, así como en la
adaptación de programas de idiomas para
estudiantes con CEA, garantizando así una
educación de calidad para todos los estudiantes.
Paganismo y cristianización entre el poder imperial y las iglesias orientales.
Authors: Sancho Gómez Miguel Pablo , Montefinese Roberto
Published: February 2025

In this work we intend to show the religious panorama of Late antique Palestine, the process of Christianization and pagan survivals in the area, comparing this process afterwards with other provinces of the Late Roman Empire. The conclusion of this work is that the survivals of what is generically called “paganism”, specially concerning magical practices, were much more abundant and persistent than was considered until now.
Recorrido histórico, enfoques y tendencias de la Salud Mental Comunitaria en Latinoamérica: Revisión integrativa de la literatura
Authors: Córdoba Castro Ernesto , Hernández Holguín Dora María
Published: February 2025

Objetivo: explorar el desarrollo del concepto de Salud Mental Comunitaria en Latinoamérica, enfocándose en sus conceptualizaciones teóricas y teniendo en cuenta sus contextos académicos y sociopolíticos. Metodología: se realizó una revisión sistemática de la literatura en las bases de datos de Scopus, SciELO y Redalyc y en fuentes externas a partir de la utilización de términos DeCS. Resultados: fueron analizados 69 registros, en los cuales se evidenció que el término de Salud Mental Comunitaria en Latinoamérica ha sido un concepto dinámico en constante transformación y que su significado depende del momento histórico y la perspectiva gnoseológica en el que se utilice. Conclusión: la hegemonía del modelo biomédico y psiquiátrico, la replicación de lógicas asilares, las nociones de salud mental desde la enfermedad y el ejercicio de poder de los Gobiernos sobre las comunidades, son considerados como desafíos persistentes para la implementación de modelos comunitarios efectivos en salud mental en Latinoamérica.
Bayesian Mechanism Design for Blockchain Transaction Fee Allocation
Authors: Chen Xi , Simchi-Levi David , Zhao Zishuo , Zhou Yuan
Published: February 2025

Reliable Blockchain Transaction Fee Mechanisms with Revenue Guarantees

In the paper “Bayesian Mechanism Design for Blockchain Transaction Fee Allocation” by Xi Chen, David Simchi-Levi, Zishuo Zhao, and Yuan Zhou, the authors address the critical challenge of designing reliable blockchain transaction fee mechanisms (TFMs) that ensure truthfulness, collusion-proofness, and desirable miner revenues. By proposing an innovative “auxiliary mechanism method,” the authors establish connections between Bayesian Nash Incentive Compatible (BNIC) and Dominant Strategy Incentive Compatible (DSIC) mechanisms through an “auxiliary-variation decomposition.” This breakthrough allows the proposed mechanism to bypass previous limitations in TFM design via the Bayesian game setting, achieving constant-ratio approximations of optimal miner revenues while providing strong incentive guarantees. The research not only advances the theoretical understanding of blockchain fee mechanisms but also demonstrates the potential versatility of the auxiliary mechanism method for designing and optimizing BNIC mechanisms across broader applications. This work represents a significant contribution to both blockchain economics and mechanism design, offering a pathway toward more reliable and efficient blockchain ecosystems.
Algorithmic Recommendation Tools and Experiential Learning in Clinical Care
Authors: Sundaresan Shirish , Guler Isin
Published: February 2025

This study examines the relationship between the adoption of algorithmic recommendation tools and experiential learning. We argue that the adoption of an algorithmic recommendation tool will harm experiential learning in organizations by limiting knowledge retention and retrieval. We further argue that the adverse relationship between algorithmic tool adoption and experiential learning will be stronger in organizations operating in low-task-difficulty environments than those in high-task-difficulty ones because organizational members in such organizations are likely to rely more on algorithmic recommendations, experiencing higher skill erosion. In addition, the relationship will be stronger in organizations facing low task variety than in those with high task variety, as these organizations are likely to have more rigid routines and in turn experience higher routine disruption after adopting an algorithmic tool. We utilize data on the adoption of an algorithmic tool called a clinical decision support system (CDSS) in a sample of emergency departments in California and utilize a fixed-effects panel regression with control function to test our arguments. We find that the relationship between cumulative experience and mortality becomes significantly weaker after CDSS adoption, suggesting flatter learning curves. We also find evidence that the effect is moderated by task difficulty and task variety.

Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2022.16738 .
Relationships between psychological, clinical aspects and eating behavior in individuals with diabetes: cross-sectional study
Authors: Kacar Mihrican , Yangilar Filiz , Karahan Yilmaz Sevil , Yilmaz Nazife
Published: February 2025

Introduction: Eating disorders are closely related to mental status, and individuals with diabetes have a significantly increased risk of developing an eating disorder.
Objective: This study aims to evaluate the possible association of cognitive restriction, uncontrolled eating, emotional eating factors, and eating disorders with depression in individuals with diabetes.
Methods: A cross-sectional study was carried out on 132 patients who were diagnosed with diabetes. The Beck Depression Inventory (BDI) was used to assess the depression status of individuals, the Three-Factor Eating Questionnaire (TFEQ-R18) to measure eating habits, and the Night Eating Questionnaire (NEQ) to obtain information about night eating behavior. All anthropometric measurements were taken by the researcher.
Results: It was determined that there was a 'mild depression' state in both the Type 1 diabetes patient group (14.10±8.26) and the Type 2 diabetes patient group (14.74±7.64). A linear, moderate, and significant correlation was found between BDI scores and NEQ scores in individuals with type 1 diabetes (r=0.547, p<0.001). In individuals with type 2 diabetes, an inverse, moderate, and significant correlation was found between BDI scores and cognitive restriction scores (r=-0.406, p=0.029). For the individuals in the two groups, statistically significant differences were found in the scores obtained from the BDI, NEQ, and TFEQ-R18 in terms of the history of mental illness and obesity, diabetic diet, and hypoglycemia (p<0.05).
Conclusions: In this study, it has been shown that the effect of mental illness and obesity history on current eating behavior may be on night eating behavior, cognitive restriction, and uncontrolled eating. It is likely that compliance with the diabetic diet and prevention of hypoglycemia will be reflected in eating behavior and anthropometric measurements.
Efecto del consumo de polifenoles sobre biomarcadores de inflamación y endotoxemia en personas con obesidad: una revisión sistemática.
Authors: López González Luz Adriana , González Correa Clara Helena , Astudillo Muñoz Elcy Yaned , Jaramillo López Manuel Felipe
Published: February 2025

Introducción: las enfermedades crónicas han aumentado a nivel mundial debido al estilo de vida y otros factores como el tabaquismo, el alcohol, la obesidad, la comida ultraprocesada baja en fibra, carente de frutas y verduras, etc. La evidencia científica respalda el uso de polifenoles dietarios como agentes preventivos y terapéuticos que podrían ayudar con la carga de estas patologías modulando la respuesta inflamatoria y la endotoxemia. Objetivo: evaluar los efectos del consumo de polifenoles sobre parámetros relacionados con la obesidad, como los biomarcadores inflamatorios y de endotoxemia, los perfiles glucémicos y peso en personas con esta condición. Metodología: Se realizó búsqueda de ensayos clínicos aleatorizados en bases de datos PubMed, Science Direct, Ovid y Ebsco. Se accedió a estudios sobre adultos obesos publicados entre enero de 2019 hasta marzo de 2024 que evaluaran el efecto de los polifenoles dietarios en biomarcadores de inflamación (FNTα, PCR hs, IL6 e IL10) y de endotoxemia (LPS). Resultados:  Se incluyeron 11 estudios con 506 participantes. Se evidenció en el 73% de los estudios que los biomarcadores más sensibles a la disminución con el consumo de polifenoles fueron PCR, IL6 y FNTα. Con relación a la endotoxemia la lipoproteína fijadora de lipopolisacáridos aumentó en 30% en el grupo de intervención y los lipopolisacáridos no se afectaron. La glicemia disminuyó en promedio 15% y el peso se mantuvo estable lo que indica que los polifenoles puedan ser, además, coadyuvantes en el manejo del peso. Discusión: el consumo de polifenoles evidenció tolerancia y modulación de la inflamación y la endotoxemia pero se requieren más estudios. Conclusión: los fitonutrientes dietarios son sustancias prometedoras en el manejo de la inflamación, la endotoxemia, la glicemia y el peso en pacientes con obesidad.
Risk of hospital malnutrition, inflammatory markers, and medical nutrition therapy in digestive surgery patient: a retrospective cohort study from eastern indonesia.
Authors: Marola Kartika , Bukhari Agussalim , Daud Nurpudji , Warsinggih  , Aminuddin  , Marniar
Published: February 2025

Introduction: The prevalence of hospital malnutrition in Indonesian 23.9% - 60.5%. It is important to evaluate nutritional status of patients at admission to prevent malnutrition and to identify the need for nutritional therapy. Nutrition, immunity, and the gastrointestinal tract are closely interrelated. Malnutrition is widely reported in surgical patients, especially those who have undergone major surgery, and is a particular risk in patients undergoing surgery for upper gastrointestinal cancer or colorectal cancer. Studies show a high prevalence of malnutrition or high nutritional risk during hospital admission, but this is rarely assessed in the clinical setting, especially for patients undergoing elective surgery. There has been no study on digestive surgery patients receiving medical nutritional therapy (MNT).
Method: Cohort retrospective study. This study used medical record data with a total sample of digestive surgery patients. This study identified the MUST modified scores of digestive surgery patients, with albumin, NLR, and TLC values.  Assess length of stay , mortality rate, and medical nutritional therapy.
Result: The most common diagnosis is rectal cancer. Moderate MUST score in 144 patients (40.7%), low MUST score in 140 patients (39.6%) and high MUST scores in 69 patients (19.5%). 96 patients (27%) received medical nutrition therapy, 71% with severe protein energy malnutrition diagnosis, 29% with moderate protein energy malnutrition diagnosis.
Hospital malnutrition in gastro-entero-hepatology (GEH) patients and its relationship to clinical outcomes: a retrospective cohort study.
Authors: Maya Maya Rosmaria Puspita , Aminuddin Aminuddin , Taslim Nurpudji A.
Published: February 2025

Background: Hospital malnutrition remains a significant global health burden, particularly among gastro-entero-hepatology patients. It adversely impacts clinical outcomes, prolongs hospital stays, and raises healthcare costs. Despite its relevance, recent data on malnutrition among Indonesia’s gastro-entero-hepatology (GEH) patients are limited.
Objective: To determine the prevalence of malnutrition and its associated risk factors and clinical outcomes, inflammatory markers, and Prognostic Nutritional Index (PNI) in GEH patients at Wahidin Sudirohusodo General Hospital.
Methods: A retrospective cohort study was conducted among 569 GEH inpatients aged 18–59 years with hospital stays exceeding 7 days. Nutritional risk was assessed using the Malnutrition Screening Tool (MST), while Neutrophil-Lymphocyte Ratio (NLR), Total Lymphocyte Count (TLC), and Prognostic Nutritional Index (PNI) were measured as inflammatory markers. Statistical analyses evaluated correlations between malnutrition risk, clinical outcomes, and laboratory values.
Results: Of the 569 patients, 7.4% were at high risk of malnutrition, 38.7% at moderate risk, and 54% at low risk. High-risk patients showed significantly elevated NLR (p = 0.000) and lower TLC (p = 0.000), reflecting an impaired immune response. These patients also had a lower PNI (p = 0.000) and more extended hospital stays (p = 0.000). No significant difference in mortality was found between different malnutrition risk groups.
Conclusion: Malnutrition is prevalent among GEH patients, particularly those with malignancies. Early nutritional screening and appropriate interventions are essential to improving clinical outcomes and reducing hospital stay durations. A multidisciplinary approach is necessary to optimize patient care.
Lista de espécies de Amphipoda (Crustacea) coletados em três localidades no entorno da entrada da Baía da Guanabara, Rio de Janeiro, Brasil
Authors: M. Cummings Victoria , Queiroz Beatriz , F.M. Canechia Mirella , Sorrentino Rayane , V. Araujo Fabio , Resende de Senna Andre
Published: February 2025

Um levantamento faunístico de crustáceos Amphipoda foi realizado entre agosto de 2019 e fevereiro de 2020, em três sítios de coleta, ao longo da costa do estado do Rio de Janeiro, próximos à entrada da Baía da Guanabara: Praia da Urca, Baía da Guanabara, município do Rio de Janeiro; Praia de Itaipu, região oceânica do município de Niterói; e Ilhas Maricás, ao largo de Itaipuaçu, município de Maricá. Em cada área de estudo, foram coletadas algas, esponjas e ascídias, para estudo da fauna associada, a profundidades que variaram de 1 a 6 m. Ao todo, foram identificadas 23 espécies de Amphipoda, agrupadas em 17 gêneros e 12 famílias.
Do Refresco Elétrico a Bowsette: formação de comunidade nos jogos digitais
Authors: Soares Nilson Valdevino , Petry Luís Carlos
Published: February 2025

Neste artigo centramo-nos na relação entre as comunidades virtuais circundantes aos jogos digitais e a produção de conteúdo pelos jogadores. É de interesse, aqui, como o senso de comunhão atua como agente motivador para criação colaborativa e como a geração de conteúdo atua em prol da comunidade, na conformação tanto de um ponto de recursos comunal, como de um lugar de referência para a construção cultural comunitária.
O Circuito da Diversão ou Da Ludologia à Ideologia: Diversão, Escapismo e Exclusão na Cultura de Jogo Digital
Authors: Goulart Lucas Aguiar , Nardi Henrique Caetano
Published: February 2025

Esse trabalho discute o quanto a cultura dos jogos digitais acaba mantendo-se enquanto um campo que, embora aparentemente acessível e democrático, se centra em uma experiência voltada para as vivências de homens, heterossexuais, brancos e cissexuais. Utilizando-se de conceitos provenientes da teoria crítica (principalmente da Escola de Frankfurt), ponderamos o quanto a compreensão clássica de “círculo mágico” acaba por decorrer na manutenção de uma compreensão de “diversão” calcada em uma compreensão de “anti-política”. Dessa maneira, os jogos digitais mainstream acabam mantendo culturas e comunidades baseadas manutenção do status quo identitário e de uma ideologia neoliberal de mercado.
Nas Ruas de Dentro de Casa: Experiência Urbana na Fruição Imersiva do Game Watch_Dogs
Authors: Abath Daniel Neves
Published: February 2025

O cenário contemporâneo dos jogos eletrônicos tem dado mostras de que a competência do jogador não está mais limitada a interações psicomotoras com vistas ao fim de sagrar-se vencedor. A permanência do jogador nos espaços virtuais em modo singleplayer, no uso solitário que faz da máquina, como nos casos dos games de ação em mundo aberto que representam cidades reais, leva-nos à constatação de uma fruição do objeto técnico satisfeita no simples “estado de estar” no jogo, permitindo uma espécie de experiência urbana a partir do contato com os conteúdos midiáticos. Disso advêm as análises que demonstramos, tais como as percepções reflexivas da cibervivência da vida urbana através do game Watch_Dogs, ambientado na cidade de Chicago.
Participação na Arte Contemporânea: a ludicidade em obras tecnolológicas de artistas brasileiros
Authors: Campos Junqueira Flávia
Published: February 2025

Entendendo a Arte Contemporânea como um processo relacional, portanto não acabado em si mesmo, o presente artigo busca destacar o lúdico como uma das características presentes na poética participativa de certas obras tecnológicas de artistas brasileiros contemporâneos. Tal perspectiva consiste em um recorte da tese defendida, intitulada Poéticas participativas contemporâneas: o engajamento dos sentidos na arte tecnológica brasileira.
Gestos e imagens de jogos digitais: apontamentos para uma gestualidade fotográfica do gameworld
Authors: Paula Julieth , Kilpp Suzana
Published: February 2025

Este texto é resultado de aproximações teóricas e empíricas entre a fotografia e os games. Orientado pela noção de gestualidades fotográficas, o artigo apresenta três tipos de gestos fotográficos nos jogos digitais: o modo foto; o gesto fotográfico como ação principal e o gesto como ação secundária. As inferências mais imediatas que permeiam o fenômeno chamado in-game photography apontam para uma reconfiguração técnica e estética da produção, fruição e compartilhamento da imagem digital contemporânea acionada no mundo dos games.
Comunicação, Mídia, Videogames
Authors: Ferreira Emmanoel , Falcão Thiago
Published: February 2025

Editorial
A estrutura mítica narcísica no imaginário midiático e nas selfies
Authors: Ciquini Fabio Henrique
Published: February 2025

O artigo discute o modo como o imaginário midiático e as selfies atualizam o mitologema do mito grego de Narciso. Partindo de um diagnóstico cultural sobre as selfies, argumenta-se como esta narrativa de estética fugaz reforça a compulsão pela imagem e a pasteurização da subjetividade. Vinculando as selfies ao macroambiente midiático, explica-se este sob o conceito de imaginário em Kamper (2016) e mediosfera em Contrera (2010). Em seguida, explica-se de que modo a estrutura mítica, o mitologema, do mito grego de Narciso se encarna no imaginário midiático e nas selfies, a partir de autores como Hollis (2005) e Brandão (2013, 2014). A estratégia metodológica é a pesquisa bibliográfica de caráter interdisciplinar, de forma a articular selfies, imaginário midiático e o mitologema de Narciso. Neste sentido, o artigo, de natureza teórica, contribui criticamente para analisar como essas instâncias reforçam padrões de visibilidade e comunicação narcísicas presentes na atualidade.
As transformações do ator-personagem no rito cinematográfico
Authors: Ventura Cristiane Moreira , Satler Lara Lima
Published: February 2025

Considerando a emergência da forma híbrida de certa cinematografia brasileira contemporânea, a qual se utiliza em sua estratégia de realização a performance do ator-personagem em seus papéis sociais, pretendemos examinar a realização como um rito de passagem,  a fim de compreender as transformações que ocorrem tanto no modo de fazer cinema, quanto às que ocorrem com o próprio ator-personagem ao se “iniciar” no meio cinematográfico.
O Afroperspectivismo de A Trilogia da Bicha Preta, de Juan Rodrigues: construindo as estéticas das resistências
Authors: Sobrinho Gilberto Alexandre
Published: February 2025

O artigo parte do estabelecimento do campo do afroperspectivismo, em que se define um olhar posicionado, do ponto de vista etnico-racial, para se chegar à análise da Trilogia da Bicha Preta, curtas-metragens dirigidos por Juan Rodrigues, em formato de filme ensaio que desenvolvem o que se concebe como o cinema da negritude queer.
Epifanias de Urubutsin na sagração de Upaon-Açu: montagem e memória na insurreição do conhecimento.
Authors: Greciano Merino Alberto
Published: February 2025

O presente trabalho procura desenvolver uma reflexão crítica sobre as possibilidades estéticas do cinema para investigar as múltiplas facetas que  fundamentam a realidade e sobre sua capacidade para que esse exercício se torne uma forma de pensar e proceder diante da história. Para tal fim, desenvolve-se uma análise interpretativa da tática discursivo-reflexiva utilizada na montagem do filme "Urubutsin e a Sagração de Upaon-Açu". As possibilidades que traz esse procedimento de montagem vão se embasar a partir de um marco teórico que aborda conceitos transversais para definir o caráter conflituoso e instável na/da imagem. O interesse é aventar a ideia de que as imagens são tocadas por contingências para instigar uma consciência de que a mirada sobre a realidade é uma tomada de posição social e historicamente determinada.
O audiovisual pervasivo do Movimento Brasil Livre nos Sites de Redes Sociais
Authors: Lepri Adil Giovanni
Published: February 2025

O artigo pretende contribuir para pensar o papel do audiovisual no campo da política contemporânea, com um olhar que dá centralidade ao campo de estudos do cinema e do audiovisual, realizando a análise fílmica de uma parcela do audiovisual presente nos Sites de Redes Sociais (SRS), com foco na produção do Movimento Brasil Livre (MBL) durante o período do impeachment da presidenta Dilma Rousseff.  A partir do entendimento que as matrizes do excesso, o sensacionalismo, o regime de atrações e a emergência de uma “câmera-corpo” são fundamentais na construção de endereçamento e engajamento dos espectadores, percebe-se como é operada uma certa gestão sensacionalista da política calcada nesses aspectos.
APIs de Visão Computacional: investigando mediações algorítmicas a partir de estudo de bancos de imagens
Authors: Silva Tarcízio , Mintz André , Omena Janna Joceli , Gobbo Beatrice , Oliveira Taís , Takamitsu Helen Tatiana , Pilipets Elena , Azhar Hamdan
Published: February 2025

O artigo apresenta resultados deestudo sobre Interfaces de Pro-gramação de Aplicações (API, nasigla em inglês) de visão compu-tacional e sua interpretação de re-presentações em bancos de ima-gens. A visão computacional é umcampo das ciências da computa-ção dedicado a desenvolver algo-ritmos e heurísticas para interpre-tar dados visuais, mas são aindaincipientes os métodos para suaaplicação ou investigação críticas.O estudo investigou três APIs devisão computacional por meio desua reapropriação na análise de16.000 imagens relacionadas abrasileiros, nigerianos, austríacose portugueses em dois dos maio-res bancos de imagens do ociden-te. Identificamos que: a) cada APIapresenta diferentes modos deetiquetamento das imagens; b)bancos de imagens representamvisualidades nacionais com temasrecorrentes, mostrando-se úteispara descrever figurações típi-cas emergentes; c) APIs de visãocomputacional apresentam dife-rentes graus de sensibilidade emodos de tratamento de imagensculturalmente específicas.
EDITORIAL
Authors: Abreu Elane , Libério Carolina , Maciel Jane
Published: February 2025

Quando primeiro lançamos a chamada para este dossiê, no início defevereiro de 2020, a ideia de uma quarentena global, motivada por um vírus,era ainda uma hipótese distante, um imaginário, para muitos, difícil de seconcretizar. E, no entanto, nada poderia surgir de mais emergente comoinstabilidade e conflito do que a ameaça às nossas vidas. Como atravessartempos de pandemia em 2020 sem sentir tensões de toda ordem, do assustadoraumento de pessoas infectadas e mortas no Brasil à clausura física e mentalque se impõe aos corpos que buscam sobreviver?
Framing the wall: The Palestinian resistance against the occupation in Five Broken Cameras (2011)
Authors: Amaral Diego Granja do
Published: February 2025

This paper looks at the documentary Five Broken Cameras (Palestine, Israel, France, Netherlands, 2011) to discuss the temporal implications of a quotidian under occupation. More specifically, the investigation casts light over the peaceful resistance against the Israeli wall in the Palestinian village of Bil’in portrayed by the lenses of Emad Burnat, a Palestinian villager who becomes the village´s filmmaker after the acquisition of his first camera. Upon the analysis, I claim that in the context of the Palestinian struggle, cinema is both an integral part of the resistance and an instrument to structure the experience of time in an area fragmented by the occupation.
Subjetividades em relação: diálogos entre o modelo praxiológico da Comunicação e perspectivas feministas do Sul Global
Authors: Fonseca Nathália de Sousa , Cal Danila Gentil Rodriguez , Darwich Rosângela Araújo
Published: February 2025

Este artigo discute como os processos comunicacionais, em interface com perspectivas feministas do Sul Global, corroboram com a construção de um olhar crítico às formas de dominação e mais sensível às resistências e redes de solidariedades do que as noções feministas hegemônicas. Para isso, traçamos um panorama do modo como a colonialidade do saber se materializou na distribuição desigual entre as mulheres, estabelecendo uma sujeita do feminismo a partir da noção universalista partidária do movimento que toma o ocidente como sujeito absoluto – reverberando diretamente na produção de conhecimento feminista. Discutimos ainda o papel da comunicação na construção, contestação e subversão de sentidos, tecendo reflexões a partir de inquietações de teóricas feministas descentralizadas. Por fim, argumentamos que a forma pela qual os processos comunicacionais, na afetação do comum, podem possibilitar a construção de novos sentidos, mais plurais e sensíveis às vozes anteriormente negligenciadas.
Pandemia: porque não usar
Authors: Katz Helena
Published: February 2025

Resumo: Com a proposta de praticar um “conhecimento situado” (Haraway, 1999), este artigo chama a atenção para a necessidade de identificar a lógica de dominação implicada no uso da nomeação de pandemia para a crise de saúde sanitária de alcance mundial que estamos vivendo. Tal nomeação suaviza a desigualdade que pauta o enfrentamento da Covid-19, doença que se apresenta na forma de epidemias que têm características locais. É necessário identificar o dano que causa uma imagem midiática que ignora as diferenças que deveriam ser destacadas nos modos de enfrentamento da contaminação, e que derivam das divergentes dimensões econômicas e políticas que distinguem cada lugar onde o vírus SARS-COv-2 se instala. O uso reiterado da palavra ‘pandemia’ reforça o controle sobre a desigualdade que fissura a possibilidade da garantia de existência de um mundo ‘pan’.