bluuebunny/crossref_metadata_2025 huggingface dataset:
Design Thinking: Methodological Strategy for the Creation of a Playful Application for Children with Dyslexia
Authors: Jerónimo Yedra Rubén , Almeida Aguilar María Alejandrina
Published: December 2021

The use of a methodology to address a problem facilitates work in an efficient, effective, and highly productive way. The design thinking methodology (also known as design thinking) is user-centric and oriented towards offering solutions by breaking down a problem into small parts to analyze it, to explore it, to test the results, and to create solutions that benefit the end-user. Many children have problems related to learning disorders, such as dyslexia, which occur due to the way that their brain incorporates and processes information. This can lead to them showing difficulty in some learning areas, even when their intelligence or motivation does not appear to be affected. In this research, through a mixed approach, a playful application is developed using new information and communication technologies (ICT), following a design thinking methodology, with the aim of supporting the learning of children with dyslexia through content designed with respect to their needs in order to help improve their academic performance. Data collection was carried out through observation, an interview, and record reviews. Analysis of the didactic materials allowed for the observation that content designed for the specific needs of children can work as a reinforcement for incorporating the information in an entertaining, dynamic, and friendly way, ultimately contributing to improved academic performance.
A Smart Integrated Vest for the Canine Companion of the K9 Units
Authors: Vosinakis Georgios , Krommyda Maria , Stamou Angelos , Mitro Nikos , Palazis-Aslanidis Marios , Voulgary Katerina , Athanasiadis Spyros , Amditis Angelos
Published: December 2021

Search and rescue operations can range from small, confined spaces, such as collapsed buildings, to large area searches during missing person operations. K9 units are tasked with intervening in such emergencies and assist in the optimal way to ensure a successful outcome for the mission. They are required to operate in unknown situations were the lives of the K9 handler and the canine companion are threatened as they operate with limited situational awareness. Within the context of the INGENIOUS project, we developed a K9 vest for the canine companion of the unit, aiming to increase the unit’s safety while operating in the field, assist the K9 handler in better monitoring the location and the environment of the K9 and increase the information provided to the Command and Control Center during the operation.
Tripodal Oxazolidine-N-Oxyl Diradical Complexes of Dy3+ and Eu3+
Authors: Rey Philippe , Caneschi Andrea , Sukhikh Taisiya S. , Vostrikova Kira E.
Published: December 2021

Two diradical complexes of the formula [LnRad2(CF3SO3)3] c (Ln(III) = Dy, Eu, Rad = 4,4-dimethyl-2,2-bis(pyridin-2-yl)-1,3-oxazolidine-3-oxyl) were obtained in air conditions. These are the first examples of diradical compounds of lanthanides and oxazolidine nitroxide. The complexes were characterized crystallographically and magnetically. Single crystal XRD analysis revealed that their coordination sphere is composed of three monodentate triflates and two tripodal Rad, which coordinate the central atom in a tridentate manner via two N atoms of the pyridine groups and the O atom of a nitroxide group. The LnO5N4 polyhedron represents a spherical capped square antiprism with point symmetry close to C4v. The data of static magnetic measurements are compatible with the presence of two paramagnetic ligands in the coordination sphere of the metal.
The Operation of a Three-Bladed Horizontal Axis Wind Turbine under Hailstorm Conditions—A Computational Study Focused on Aerodynamic Performance
Authors: Douvi Dimitra , Douvi Eleni , Margaris Dionissios P.
Published: December 2021

The aim of this study is the aerodynamic degradation of a three-bladed Horizontal Axis Wind Turbine (HAWT) under the influence of a hailstorm. The importance and originality of this study are that it explores the aerodynamic performance of an optimum wind turbine blade during a hailstorm, when hailstones and raindrops are present. The commercial Computational Fluid Dynamics (CFD) code ANSYS Fluent 16.0 was utilized for the simulation. The first step was the calculation of the optimum blade geometry characteristics for a three-bladed rotor, i.e., twist and chord length along the blade, by a user-friendly application. Afterwards, the three-dimensional blade and the flow field domain were designed and meshed appropriately. The rotary motion of the blades was accomplished by the application of the Moving Reference Frame Model and the simulation of hailstorm conditions by the Discrete Phase Model. The SST k–ω turbulence model was also added. The produced power of the wind turbine, operating in various environmental conditions, was estimated and discussed. Contours of pressure, hailstone and raindrop concentration and erosion rate, on both sides of the blade, are presented. Moreover, contours of velocity at various cross sections parallel to the rotor are demonstrated, to understand the effect of hailstorms on the wake behavior. The results suggest that the aerodynamic performance of a HAWT degrades due to impact and breakup of the particles on the blade.
Development of an Approach for Determining the Effectiveness of Inhibition of Paraffin Deposition on the Wax Flow Loop Laboratory Installation
Authors: Ilushin Pavel , Vyatkin Kirill , Kozlov Anton
Published: December 2021

The formation of wax deposits is a common phenomenon in the production and transportation of formation fluids. On the territory of the Perm Krai, this problem occurs in half of the mining funds. One of the most common and promising methods of dealing with these deposits is the use of inhibitor regents. The most popular technique for assessing the effectiveness of a wax inhibitor is the «Cold Finger», which has a number of significant drawbacks. This work presents a number of methods for assessing the effectiveness of inhibition of paraffin formation on the laboratory installation «WaxFlowLoop». A number of laboratory studies have been carried out to determine the effectiveness of a paraffin deposition inhibitor for inhibiting the paraffin formation process of four target fluids. Verification of the obtained values was carried out by comparing them with the field data. As a result of laboratory studies, it was found that the value of the inhibitor efficiency, determined by the «Cold Finger» method, differs from the field data by an average of 2 times. At the same time, the average deviation of the results determined at the «WaxFlowLoop» installation from the field data is 8.1%. The correct selection of a paraffin deposition inhibitor and its dosage can significantly increase the inter-treatment period of the well, thereby reducing its maintenance costs and increasing the efficiency of well operation.
Characterizing Neonatal Heart Maturation, Regeneration, and Scar Resolution Using Spatial Transcriptomics
Authors: Misra Adwiteeya , Baker Cameron D. , Pritchett Elizabeth M. , Burgos Villar Kimberly N. , Ashton John M. , Small Eric M.
Published: December 2021

The neonatal mammalian heart exhibits a remarkable regenerative potential, which includes fibrotic scar resolution and the generation of new cardiomyocytes. To investigate the mechanisms facilitating heart repair after apical resection in neonatal mice, we conducted bulk and spatial transcriptomic analyses at regenerative and non-regenerative timepoints. Importantly, spatial transcriptomics provided near single-cell resolution, revealing distinct domains of atrial and ventricular myocardium that exhibit dynamic phenotypic alterations during postnatal heart maturation. Spatial transcriptomics also defined the cardiac scar, which transitions from a proliferative to secretory phenotype as the heart loses regenerative potential. The resolving scar is characterized by spatially and temporally restricted programs of inflammation, epicardium expansion and extracellular matrix production, metabolic reprogramming, lipogenic scar extrusion, and cardiomyocyte restoration. Finally, this study revealed the emergence of a regenerative border zone defined by immature cardiomyocyte markers and the robust expression of Sprr1a. Taken together, our study defines the spatially and temporally restricted gene programs that underlie neonatal heart regeneration and provides insight into cardio-restorative mechanisms supporting scar resolution.
Not Only Diagnostic Yield: Whole-Exome Sequencing in Infantile Cardiomyopathies Impacts on Clinical and Family Management
Authors: Pezzoli Laura , Pezzani Lidia , Bonanomi Ezio , Marrone Chiara , Scatigno Agnese , Cereda Anna , Bedeschi Maria Francesca , Selicorni Angelo , Gasperini Serena , Bini Paolo , Maitz Silvia , Maccioni Carla , Pedron Cristina , Colombo Lorenzo , Marchetti Daniela , Bellini Matteo , Lincesso Anna Rita , Perego Loredana , Pingue Monica , Della Malva Nunzia , Mangili Giovanna , Ferrazzi Paolo , Iascone Maria
Published: December 2021

Whole-exome sequencing (WES) is a powerful and comprehensive tool for the genetic diagnosis of rare diseases, but few reports describe its timely application and clinical impact on infantile cardiomyopathies (CM). We conducted a retrospective analysis of patients with infantile CMs who had trio (proband and parents)-WES to determine whether results contributed to clinical management in urgent and non-urgent settings. Twenty-nine out of 42 enrolled patients (69.0%) received a definitive molecular diagnosis. The mean time-to-diagnosis was 9.7 days in urgent settings, and 17 out of 24 patients (70.8%) obtained an etiological classification. In non-urgent settings, the mean time-to-diagnosis was 225 days, and 12 out of 18 patients (66.7%) had a molecular diagnosis. In 37 out of 42 patients (88.1%), the genetic findings contributed to clinical management, including heart transplantation, palliative care, or medical treatment, independent of the patient’s critical condition. All 29 patients and families with a definitive diagnosis received specific counseling about recurrence risk, and in seven (24.1%) cases, the result facilitated diagnosis in parents or siblings. In conclusion, genetic diagnosis significantly contributes to patients’ clinical and family management, and trio-WES should be performed promptly to be an essential part of care in infantile cardiomyopathy, maximizing its clinical utility.
Setting for “Normal” Serum Ferritin Levels in Patients with Transfusion-Dependent Thalassemia: Our Current Strategy
Authors: Spasiano Anna , Meloni Antonella , Costantini Silvia , Quaia Emilio , Cademartiri Filippo , Cinque Patrizia , Pepe Alessia , Ricchi Paolo
Published: December 2021

This cross-sectional study aimed to establish the association between serum ferritin levels and organ iron overload (IO) and overall morbidity in transfusion-dependent thalassemia (TDT) patients. One hundred and three TDT patients (40.03 ± 9.15 years; 57.3% females) with serum ferritin < 2500 ng/mL were included. IO was assessed by T2* magnetic resonance imaging. Three groups were identified based on mean serum ferritin levels: <500 ng/mL (group 0; N = 32), 500–1000 ng/mL (group 1; N = 43), and 1000–2500 ng/mL (group 2; N = 28). All demographic and biochemical parameters were comparable among the three groups, with the exception of the triglycerides being significantly lower in group 0 than in group 2. No difference was found in the frequency of hepatic, endocrine, and cardiac complications. Hepatic IO was significantly less frequent in group 0 versus both groups 1 and 2. No patient with a serum ferritin level < 500 ng/mL had significant myocardial IO and alterations in the main hematological parameters. No difference in the distribution of the different chelation regimens was found. Serum ferritin < 500 ng/mL appears to be achievable and safe for several TDT patients. This target is associated with the absence of significant cardiac iron and significantly lower hepatic IO and triglycerides that are well-demonstrated markers for cardiac and liver complications.
Amyloid Beta Dynamics in Biological Fluids—Therapeutic Impact
Authors: Schreiner Thomas Gabriel , Popescu Bogdan Ovidiu
Published: December 2021

Despite the significant impact of Alzheimer’s disease (AD) at individual and socioeconomic levels and the numerous research studies carried out on this topic over the last decades, the treatments available in daily clinical practice remain less than satisfactory. Among the accepted etiopathogenic hypotheses, the amyloidogenic pathway theory, although intensively studied and even sometimes controversial, is still providing relevant theoretical elements for understanding the etiology of AD and for the further development of possible therapeutic tools. In this sense, this review aims to offer new insights related to beta amyloid (Aβ), an essential biomarker in AD. First the structure and function of Aβ in normal and pathological conditions are presented in detail, followed by a discussion on the dynamics of Aβ at the level of different biological compartments. There is focus on Aβ elimination modalities at central nervous system (CNS) level, and clearance via the blood–brain barrier seems to play a crucial/dominant role. Finally, different theoretical and already-applied therapeutic approaches for CNS Aβ elimination are presented, including the recent “peripheral sink therapeutic strategy” and “cerebrospinal fluid sinks therapeutic strategy”. These data outline the need for a multidisciplinary approach designed to deliver a solution to stimulate Aβ clearance in more direct ways, including from the cerebrospinal fluid level.
Management of Coagulopathy in Bleeding Patients
Authors: Hofer Stefan , Schlimp Christoph J. , Casu Sebastian , Grouzi Elisavet
Published: December 2021

Early recognition of coagulopathy is necessary for its prompt correction and successful management. Novel approaches, such as point-of-care testing (POC) and administration of coagulation factor concentrates (CFCs), aim to tailor the haemostatic therapy to each patient and thus reduce the risks of over- or under-transfusion. CFCs are an effective alternative to ratio-based transfusion therapies for the correction of different types of coagulopathies. In case of major bleeding or urgent surgery in patients treated with vitamin K antagonist anticoagulants, prothrombin complex concentrate (PCC) can effectively reverse the effects of the anticoagulant drug. Evidence for PCC effectiveness in the treatment of direct oral anticoagulants-associated bleeding is also increasing and PCC is recommended in guidelines as an alternative to specific reversal agents. In trauma-induced coagulopathy, fibrinogen concentrate is the preferred first-line treatment for hypofibrinogenaemia. Goal-directed coagulation management algorithms based on POC results provide guidance on how to adjust the treatment to the needs of the patient. When POC is not available, concentrate-based management can be guided by other parameters, such as blood gas analysis, thus providing an important alternative. Overall, tailored haemostatic therapies offer a more targeted approach to increase the concentration of coagulation factors in bleeding patients than traditional transfusion protocols.
A Comparative Study of the Effectiveness of Pharmacopuncture Therapy for Chronic Neck Pain: A Pragmatic, Randomized, Controlled Trial
Authors: Park Kyoung-Sun , Kim Suna , Kim Changnyun , Seo Ji-Yeon , Cho Hyunwoo , Kim Sang-Don , Lee Yoon-Jae , Lee Jinho , Ha In-Hyuk
Published: December 2021

Background: This two-arm, parallel, pragmatic, multicenter, clinical randomized, controlled trial with a 12-week follow-up period aimed to compare the effectiveness of pharmacopuncture therapy and physical therapy strategies for chronic neck pain. Methods: Eight sessions of pharmacopuncture therapy or physical therapy were administered within 2 weeks. The primary outcome was the visual analogue scale (VAS) score for neck pain. The secondary outcomes were the scores of the Northwick Park questionnaire (NPQ), VAS score for radiating arm pain, numeric rating scale (NRS) for neck and arm bothersomeness, neck disability index (NDI), patient global impression of change (PGIC), 12-item short form health survey (SF-12), and EuroQoL 5-dimension 5-level (EQ-5D-5L) instrument. The protocol was registered with Clinicaltrials.gov (NCT04035018) and CRIS (KCT0004243). Results: We randomly allocated 101 participants with chronic neck pain to the pharmacopuncture therapy (n = 50) or physical therapy group (n = 51). At the primary endpoint (week 5) the pharmacopuncture therapy group showed significantly superior effects regarding VAS score for neck pain and arm bothersomeness, NRS for neck pain, NDI, NPQ, and PGIC compared with the physical therapy group. These effects were sustained up to 12 weeks after follow-up. Conclusion: Compared with physical therapy, pharmacopuncture therapy had superior effects on the pain and functional recovery of patients with chronic neck pain.
Influence of COVID-19 Restrictions on Training and Physiological Characteristics in U23 Elite Cyclists
Authors: Leo Peter , Mujika Iñigo , Lawley Justin
Published: December 2021

PURPOSE: The COVID-19 pandemic and its associated mobility restrictions caused many athletes to adjust or reduce their usual training load. The aim of this study was to investigate how the COVID-19 restrictions affected training and performance physiology measures in U23 elite cyclists. METHODS: Twelve U23 elite cyclists (n = 12) participated in this study (mean ± SD: Age 21.2 ± 1.2 years; height 182.9 ± 4.7 cm; body mass 71.4 ± 6.5 kg). Training characteristics were assessed between 30 days pre, during, and post COVID-19 restrictions, respectively. The physiological assessment in the laboratory was 30 days pre and post COVID-19 restrictions and included maximum oxygen uptake (V̇O2max), peak power output for sprint (SprintPmax), and ramp incremental graded exercise (GXTPmax), as well as power output at ventilatory threshold (VT) and respiratory compensation point (RCP). RESULTS: Training load characteristics before, during, and after the lockdown remained statistically unchanged (p > 0.05) despite large effects (>0.8) with mean reductions of 4.7 to 25.0% during COVID-19 restrictions. There were no significant differences in maximal and submaximal power outputs, as well as relative and absolute V̇O2max between pre and post COVID-19 restrictions (p > 0.05) with small to moderate effects. DISCUSSION: These results indicate that COVID-19 restrictions did not negatively affect training characteristics and physiological performance measures in U23 elite cyclists for a period of <30 days. In contrast with recent reports on professional cyclists and other elite level athletes, these findings reveal that as long as athletes are able to maintain and/or slightly adapt their training routine, physiological performance variables remain stable.
Hybrid Manufacturing of Stiffening Grooves in Additive Deposited Thin Parts
Authors: Cristino Valentino A. M. , Pragana João P. M. , Bragança Ivo M. F. , Silva Carlos M. A. , Martins Paulo A. F.
Published: December 2021

This paper is focused on the hybridization of additive manufacturing with single-point incremental forming to produce stiffening grooves in thin metal parts. An analytical model built upon in-plane stretching of a membrane is provided to determine the tool force as a function of the required groove depth and to estimate the maximum allowable groove depth that can be formed without tearing. The results for additively deposited stainless-steel sheets show that the proposed analytical model can replicate incremental plastic deformation of the stiffening grooves in good agreement with experimental observations and measurements. Anisotropy and lower formability caused by the dendritic-based microstructure of the additively deposited stainless-steel sheets justifies the reason why the maximum allowable depth of the stiffening grooves is approximately 27% smaller than that obtained for the wrought commercial sheets of the same material that are used for comparison purposes.
Additions to Lyophyllaceae s.l. from China
Authors: Xu Jize , Yu Xiaodong , Suwannarach Nakarin , Jiang Yi , Zhao Wei , Li Yu
Published: December 2021

Four new species, viz. Calocybe coacta, C. fulvipes, C. vinacea and Clitolyophyllum umbilicatum, are described in northern China. Comparisons are made of macro- and micromorphological features among the new species and closely related species within the genus. The new species feature unique morphological characteristics that separate them from the previously described species. Calocybe coacta is characterized by medium- to large-sized basidiocarps, greyish cream, felty pileus and non-cellular epicutis. The key characteristics of C. fulvipes are rose-brown to greyish-brown pileus, stone-brown stipe and non-cellular epicutis. The unique morphological characteristics of C. vinacea that distinguish it from its closely related species are pastel red to dull-red pileus and stipe surface with densely white pruina. The main characteristics of Clitolyophyllum umbilicatum are deeply depressed dark orange to light-brown pileus, central stipe and subglobose-ellipsoid spores. Phylogenetic analyses based on the ITS and 28S regions indicated that the four new species are distinct and monophyletic. Full descriptions, color images, illustrations and a phylogenetic tree that show the placement of the four new species are provided. A key to the Calocybe species reported from China is also given.
Twelve New Species Reveal Cryptic Diversification in Foliicolous Lichens of Strigula s.lat. (Strigulales, Ascomycota)
Authors: Jiang Shu-Hua , Lücking Robert , Liu Hua-Jie , Wei Xin-Li , Xavier-Leite Amanda Barreto , Portilla Carlos Viñas , Ren Qiang , Wei Jiang-Chun
Published: December 2021

We employed a molecular phylogenetic approach using five markers (ITS, nuSSU, nuLSU, TEF1-α, and RPB2) to assess potential cryptic speciation in foliicolous members of Strigula s.lat. (Strigulaceae), including the recently segregated genera Phylloporis, Puiggariella, Raciborskiella, Racoplaca, and Serusiauxiella, from tropical areas in Asia, with selected materials from the Neotropics as reference. On the basis of combined molecular and phenotypic datasets, two new species of Racoplaca and 10 new species of Strigula s.str. are described: Racoplaca macrospora sp. nov., R. maculatoides sp. nov., Strigula guangdongensis sp. nov., S. intermedia sp. nov., S. laevis sp. nov., S. microcarpa sp. nov., S. pseudoantillarum sp. nov., S. pseudosubtilissima sp. nov., S. pycnoradians sp. nov., S. sinoconcreta sp. nov., S. stenoloba sp. nov., and S. subtilissimoides sp. nov. In addition, we propose the new combination Phylloporis palmae comb. nov. (≡ =Manaustrum palmae) and we validate the earlier combination Racoplaca melanobapha comb. nov. (≡ Verrucaria melanobapha; Strigula melanobapha). Our data clearly indicate a considerable degree of cryptic diversification in foliicolous representatives of Strigula s.lat., particularly in the presumably widespread taxa Strigula antillarum, S. concreta, S. nitidula, and S. smaragdula. Given that these phylogenetic revisions are thus far limited to few regions, we predict that our findings only represent the proverbial tip of the iceberg in this group of lichenized fungi.
Measurement of Economic Forecast Accuracy: A Systematic Overview of the Empirical Literature
Authors: Buturac Goran
Published: December 2021

The primary purpose of the paper is to enable deeper insight into the measurement of economic forecast accuracy. The paper employs the systematic literature review as its research methodology. It is also the first systematic review of the measures of economic forecast accuracy conducted in scientific research. The citation-based analysis confirms the growing interest of researchers in the topic. Research on economic forecast accuracy is continuously developing and improving with the adoption of new methodological approaches. An overview of the limits and advantages of the methods used to assess forecast accuracy not only facilitate the selection and application of appropriate measures in future analytical works but also contribute to a better interpretation of the results. In addition to the presented advantages and disadvantages, the chronological presentation of methodological development (measures, tests, and strategies) provides an insight into the possibilities of further upgrading and improving the methodological framework. The review of empirical findings, in addition to insight into existing results, indicates insufficiently researched topics. All in all, the results presented in this paper can be a good basis and inspiration for creating new scientific contributions in future works.
A Novel Approach for the Assessment of Cities through Ecosystem Integrity
Authors: MacGregor-Fors Ian , Falfán Ina , García-Arroyo Michelle , Lemoine-Rodríguez Richard , Gómez-Martínez Miguel A. , Marín-Gómez Oscar H. , Pérez-Maqueo Octavio , Equihua Miguel
Published: December 2021

To tackle urban heterogeneity and complexity, several indices have been proposed, commonly aiming to provide information for decision-makers. In this study, we propose a novel and customizable procedure for quantifying urban ecosystem integrity. Based on a citywide approach, we developed an easy-to-use index that contrasts physical and biological variables of urban ecosystems with a given reference system. The Urban Ecosystem Integrity Index (UEII) is the sum of the averages from the variables that make up its intensity of urbanization and biological components. We applied the UEII in a Mexican tropical city using land surface temperature, built cover, and the richness of native plants and birds. The overall ecosystem integrity of the city, having montane cloud, tropical dry, and temperate forests as reference systems, was low (−0.34 ± SD 0.32), showing that, beyond its biodiverse greenspace network, the built-up structure highly differs from the ecosystems of reference. The UEII showed to be a flexible and easy-to-calculate tool to evaluate ecosystem integrity for cities, allowing for comparisons between or among cities, as well as the sectors/regions within cities. If used properly, the index could become a useful tool for decision making and resource allocation at a city level.
Exploring a Pricing Model for Urban Rental Houses from a Geographical Perspective
Authors: Shen Hang , Li Lin , Zhu Haihong , Liu Yu , Luo Zhenwei
Published: December 2021

Models for estimating urban rental house prices in the real estate market continue to pose a challenging problem due to the insufficiency of algorithms and comprehensive perspectives. Existing rental house price models based on either the geographically weighted regression (GWR) or deep-learning methods can hardly predict very satisfactory prices, since the rental house prices involve both complicated nonlinear characteristics and spatial heterogeneity. The linear-based GWR model cannot characterize the nonlinear complexity of rental house prices, while existing deep-learning methods cannot explicitly model the spatial heterogeneity. This paper proposes a fully connected neural network–geographically weighted regression (FCNN–GWR) model that combines deep learning with GWR and can handle both of the problems above. In addition, when calculating the geographical location of a house, we propose a set of locational and neighborhood variables based on the quantities of nearby points of interests (POIs). Compared with traditional locational and neighborhood variables, the proposed “quantity-based” locational and neighborhood variables can cover more geographic objects and reflect the locational characteristics of a house from a comprehensive geographical perspective. Taking four major Chinese cities (Wuhan, Nanjing, Beijing, and Xi’an) as study areas, we compare the proposed method with other commonly used methods, and this paper presents a more precise estimation model for rental house prices. The method proposed in this paper may serve as a useful reference for individuals and enterprises in their transactions relevant to rental houses, and for the government in terms of the policies and positions of public rental housing.
From Automata to Multiautomata via Theory of Hypercompositional Structures
Authors: Křehlík Štěpán , Novák Michal , Vyroubalová Jana
Published: December 2021

In this paper, we study two important problems related to quasi-multiautomata: the complicated nature of verification of the GMAC condition for systems of quasi-multiautomata, and the fact that the nature of quasi-multiautomata has deviated from the original nature of automata as seen by the theory of formal languages. For the former problem, we include several new conditions that simplify the procedure. For the latter problem, we close this gap by presenting a construction of quasi-multiautomata, which corresponds to deterministic automata of the theory of formal languages and is based on the operation of concatenation.
Skew Pairs of Idempotents in Partial Transformation Semigroups
Authors: Luangchaisri Panuwat , Changphas Thawhat
Published: December 2021

Let S be a regular semigroup. A pair (e,f) of idempotents of S is said to be a skew pair of idempotents if fe is idempotent, but ef is not. T. S. Blyth and M. H. Almeida (T. S. Blyth and M. H. Almeida, skew pair of idempotents in transformation semigroups, Acta Math. Sin. (English Series), 22 (2006), 1705–1714) gave a characterization of four types of skew pairs—those that are strong, left regular, right regular, and discrete—existing in a full transformation semigroup T(X). In this paper, we do in this line for partial transformation semigroups.
Rotating Flow in a Nanofluid with CNT Nanoparticles over a Stretching/Shrinking Surface
Authors: Yacob Nor Azizah , Dzulkifli Nor Fadhilah , Salleh Siti Nur Alwani , Ishak Anuar , Pop Ioan
Published: December 2021

The steady three-dimensional rotating flow past a stretching/shrinking surface in water and kerosene-based nanofluids containing single and multi-walled carbon nanotubes (CNTs) is investigated. The governing equations are converted to similarity equations, and then numerically solved using MATLAB software. The impacts of rotational, suction, and nanoparticle volume fraction on the flow and the thermal fields, as well as velocity and temperature gradients at the surface, are represented graphically and are analyzed. Further, the friction factor and the heat transfer rate for different parameters are presented in tables. It is found that the heat transfer rate increases with increasing nanoparticle volume fraction as well as suction parameter in water and kerosene-based nanofluids of single and multi-walled CNTs. However, the increment in the rotating flow parameter decreases the rate of heat transfer. Multi-walled carbon nanotubes and kerosene-based nanofluid contribute to heat transfer rates better than single-walled carbon nanotubes and water-based nanofluid, respectively. A unique solution exists for the stretching surface, while two solutions are obtained for the shrinking surface. Further analysis of their stabilities shows that only one of them is stable over time.
A Novel LSB Matching Algorithm Based on Information Pre-Processing
Authors: Hu Yongjin , Li Xiyan , Ma Jun
Published: December 2021

This paper analyzes random bits and scanned documents, two forms of secret data. The secret data were pre-processed by halftone, quadtree, and S-Box transformations, and the size of the scanned document was reduced by 8.11 times. A novel LSB matching algorithm with low distortion was proposed for the embedding step. The golden ratio was firstly applied to find the optimal embedding position and was used to design the matching function. Both theory and experiment have demonstrated that our study presented a good trade-off between high capacity and low distortion and is superior to other related schemes.
Early Mathematics Learning and Teaching in Chinese Preschools: A Content Analysis of Teaching Reference Books for Preschool Teachers
Authors: Sun Jin , Qin Han , Lee Kerry , Bautista Alfredo , Zhang Qiaoping
Published: December 2021

Since the 1980s, Chinese children have consistently been found to perform well in mathematics in cross-national studies of academic achievement. This study is one of the first to systematically examine Chinese children’s early mathematics learning experiences through a content analysis of eight sets of preschool teacher’s teaching reference books that are commonly used in China. A total of 2038 mathematics activities were selected from these classic teaching reference books and analyzed in terms of (i) suggested teaching approaches, (ii) the mathematical concepts covered, and (iii) their integration of a problem-solving component. The results showed that early mathematics teaching in Chinese preschools emphasize the mastery of key mathematical concepts and skills, while less attention is paid to the application of these key concepts in real-life and non-routine problem-solving settings. Collective teaching was found to be the major teaching mode for early mathematics activities in Chinese preschools, with teachers playing a leading role in the collective teaching activities described in the reference books. However, the teacher’s role is not described in detail in the learning corner activities, and few activities were found to integrate a problem-solving component. The implications of these findings for early mathematics education and the need for a more comprehensive review of mathematics education from the pre-primary to secondary stages are discussed.
Well-Balanced High-Order Discontinuous Galerkin Methods for Systems of Balance Laws
Authors: Guerrero Fernández Ernesto , Escalante Cipriano , Castro Díaz Manuel J.
Published: December 2021

This work introduces a general strategy to develop well-balanced high-order Discontinuous Galerkin (DG) numerical schemes for systems of balance laws. The essence of our approach is a local projection step that guarantees the exactly well-balanced character of the resulting numerical method for smooth stationary solutions. The strategy can be adapted to some well-known different time marching DG discretisations. Particularly, in this article, Runge–Kutta DG and ADER DG methods are studied. Additionally, a limiting procedure based on a modified WENO approach is described to deal with the spurious oscillations generated in the presence of non-smooth solutions, keeping the well-balanced properties of the scheme intact. The resulting numerical method is then exactly well-balanced and high-order in space and time for smooth solutions. Finally, some numerical results are depicted using different systems of balance laws to show the performance of the introduced numerical strategy.
Computational Analysis and Bifurcation of Regular and Chaotic Ca2+ Oscillations
Authors: Qie Xinxin , Ji Quanbao
Published: December 2021

This study investigated the stability and bifurcation of a nonlinear system model developed by Marhl et al. based on the total Ca2+ concentration among three different Ca2+ stores. In this study, qualitative theories of center manifold and bifurcation were used to analyze the stability of equilibria. The bifurcation parameter drove the system to undergo two supercritical bifurcations. It was hypothesized that the appearance and disappearance of Ca2+ oscillations are driven by them. At the same time, saddle-node bifurcation and torus bifurcation were also found in the process of exploring bifurcation. Finally, numerical simulation was carried out to determine the validity of the proposed approach by drawing bifurcation diagrams, time series, phase portraits, etc.
Identifying the Structure of CSCL Conversations Using String Kernels
Authors: Masala Mihai , Ruseti Stefan , Rebedea Traian , Dascalu Mihai , Gutu-Robu Gabriel , Trausan-Matu Stefan
Published: December 2021

Computer-Supported Collaborative Learning tools are exhibiting an increased popularity in education, as they allow multiple participants to easily communicate, share knowledge, solve problems collaboratively, or seek advice. Nevertheless, multi-participant conversation logs are often hard to follow by teachers due to the mixture of multiple and many times concurrent discussion threads, with different interaction patterns between participants. Automated guidance can be provided with the help of Natural Language Processing techniques that target the identification of topic mixtures and of semantic links between utterances in order to adequately observe the debate and continuation of ideas. This paper introduces a method for discovering such semantic links embedded within chat conversations using string kernels, word embeddings, and neural networks. Our approach was validated on two datasets and obtained state-of-the-art results on both. Trained on a relatively small set of conversations, our models relying on string kernels are very effective for detecting such semantic links with a matching accuracy larger than 50% and represent a better alternative to complex deep neural networks, frequently employed in various Natural Language Processing tasks where large datasets are available.
ARNI Pre-Operative Use and Vasoplegic Syndrome in Patients Undergoing Heart Transplantation or Left Ventricular Assist Device Surgery
Authors: Haider Lamis , Hugon-Vallet Elisabeth , Constantin Jean Philippe , Riad Zakaria , Sebbag Laurent , Mewton Nathan
Published: December 2021

Background: Vasoplegic syndrome after orthotopic heart transplantation (OHT) or left ventricular assist device (LVAD) implantation is a rare but highly lethal syndrome with complex etiologies. The objective of this study was to assess if the preoperative use of sacubitril-valsartan combination is associated with an increased vasoplegic syndrome (VS) frequency after OHT or LVAD implantation and its relationship with 30-day mortality. Methods: A retrospective review of perioperative data, between January 2016 and December 2017, from 73 consecutive OHT and LVAD surgery adult patients at our institution was performed. VS was defined as normal cardiac output with persistent low systemic resistance requiring a norepinephrine intravenous perfusion > 0.5 µg/kg/min and the absence of sepsis or hemorrhagic shock within 48 h after surgery. Patients were all followed-up for adverse events and all-cause mortality at 30 days. Results: In our cohort of 73 patients (median age 51.7 years, 65% male patients), 25 (34%) patients developed VS. Twenty-two (30.1%) patients were on ARNI at the time of surgery, 31 (42.5%) were on other RAS blockers, 12 (16.4%) were on norepinephrine and 8 (11%) had no pre-operative drug. The pre-operative use of any vasoactive agent, was not significantly associated with VS (OR = 1.36; IC95% [0.78; 2.35]; p = 0.38). The pre-operative use of an ARNI compared to all other groups was not significantly associated with VS (OR = 2.0; IC95% [0.71; 5.62]; p = 0.19). The pre-operative use of an ARNI compared to other RAS blockers was also not significantly associated with VS (OR = 1.25; IC95% [0.37; 4.26]; p = 0.72). At 30 days, 18 (24.7%) patients had died. The pre-operative treatment with ARNI, or other RAS inhibitors was associated with a significantly lower rate of death compared to the absence of treatment (HR = 0.11; IC95% [0.02; 0.55]; p = 0.009 for ARNI and HR = 0.20; IC95% [0.06; 0.69]; p = 0.011 for other RASi). Conclusions: Preoperative use of sacubitril-valsartan was not significantly associated with development of vasoplegic syndrome in patients undergoing OHT or LVAD surgery. Furthermore, our data suggests a significant 30-day survival benefit with efficient renin-angiotensin blockade before surgery.
Trans-Translation Is an Appealing Target for the Development of New Antimicrobial Compounds
Authors: Campos-Silva Rodrigo , D’Urso Gaetano , Delalande Olivier , Giudice Emmanuel , Macedo Alexandre José , Gillet Reynald
Published: December 2021

Because of the ever-increasing multidrug resistance in microorganisms, it is crucial that we find and develop new antibiotics, especially molecules with different targets and mechanisms of action than those of the antibiotics in use today. Translation is a fundamental process that uses a large portion of the cell’s energy, and the ribosome is already the target of more than half of the antibiotics in clinical use. However, this process is highly regulated, and its quality control machinery is actively studied as a possible target for new inhibitors. In bacteria, ribosomal stalling is a frequent event that jeopardizes bacterial wellness, and the most severe form occurs when ribosomes stall at the 3′-end of mRNA molecules devoid of a stop codon. Trans-translation is the principal and most sophisticated quality control mechanism for solving this problem, which would otherwise result in inefficient or even toxic protein synthesis. It is based on the complex made by tmRNA and SmpB, and because trans-translation is absent in eukaryotes, but necessary for bacterial fitness or survival, it is an exciting and realistic target for new antibiotics. Here, we describe the current and future prospects for developing what we hope will be a novel generation of trans-translation inhibitors.
How Can Autonomous Vehicles Convey Emotions to Pedestrians? A Review of Emotionally Expressive Non-Humanoid Robots
Authors: Wang Yiyuan , Hespanhol Luke , Tomitsch Martin
Published: December 2021

In recent years, researchers and manufacturers have started to investigate ways to enable autonomous vehicles (AVs) to interact with nearby pedestrians in compensation for the absence of human drivers. The majority of these efforts focuses on external human–machine interfaces (eHMIs), using different modalities, such as light patterns or on-road projections, to communicate the AV’s intent and awareness. In this paper, we investigate the potential role of affective interfaces to convey emotions via eHMIs. To date, little is known about the role that affective interfaces can play in supporting AV–pedestrian interaction. However, emotions have been employed in many smaller social robots, from domestic companions to outdoor aerial robots in the form of drones. To develop a foundation for affective AV–pedestrian interfaces, we reviewed the emotional expressions of non-humanoid robots in 25 articles published between 2011 and 2021. Based on findings from the review, we present a set of considerations for designing affective AV–pedestrian interfaces and highlight avenues for investigating these opportunities in future studies.
Analysis of Phenolic Compounds for the Determination of Grafts (in) Compatibility Using In Vitro Callus Cultures of Sato-Zakura Cherries
Authors: Skočajić Dragana , Gašić Uroš , Dabić Zagorac Dragana , Nešić Marija , Tešić Živoslav , Meland Mekjell , Fotirić Akšić Milica
Published: December 2021

The aim of this study was to prove that under in vitro conditions, the adhesiveness of the callus between rootstock and scion, the development of callus cells at the points of fusion, and the presence of phenolic components are closely related to the level of (in) compatibility of the grafting combinations between Sato-zakura cherry cultivars (‘Amanogawa’, ‘Kanzan’, and ‘Kiku-shidare-zakura’) and commercial rootstocks. Prunus avium, Prunus ‘Colt’, Prunus mahaleb and Prunus serrulata were used as compatible and Prunus serotina and Pyrus communis ‘Pyrodwarf’ were used as two potentially incompatible rootstocks. The results indicated the significant manifestations of the early signs of the incompatibility on the callus junction. Phenols, as well as tissue senescence, were very precisely localized by toluidine blue and alcian blue as well as safranin staining, which can indicate the early signs of the callus incompatibility in some grafting unions. In the callus unions of Prunus avium with ‘Amanogawa’ and ‘Kiku-shidare-zakura’ the results of chemical analyses indicated that the existence of several flavonols, flavones and phenol acids could be involved in the incompatibility process in grafted combination. The detection of flavonol astragalin in the unions can be a biomarker of compatibility between scion and the rootstock, while some polyphenols, such as neochlorogenic acid, sinapic acid, ellagic acid, caffeic acid, baicalein, naringenin, apigenin and luteolin can be used as the indicators of graft incompatibility. p-coumaric acid and ferulic acid could be used for detection of delayed incompatibility.
Allelopathy of Knotweeds as Invasive Plants
Authors: Kato-Noguchi Hisashi
Published: December 2021

Perennial herbaceous Fallopia is native to East Asia, and was introduced to Europe and North America in the 19th century as an ornamental plant. Fallopia has been spreading quickly and has naturalized in many countries. It is listed in the world’s 100 worst alien species. Fallopia often forms dense monospecies stands through the interruption of the regeneration process of indigenous plant species. Allelopathy of Japanese knotweed (Fallopia japonica), giant knotweed (Fallopia sachalinensis), and Bohemian knotweed (Fallopia x bohemica) has been reported to play an essential role in its invasion. The exudate from their roots and/or rhizomes, and their plant residues inhibited the germination and growth of some other plant species. These knotweeds, which are non-mycorrhizal plants, also suppressed the abundance and species richness of arbuscular mycorrhizal fungi (AMF) in the rhizosphere soil. Such suppression was critical for most territorial plants to form the mutualism with AMF, which enhances the nutrient and water uptake, and the tolerance against pathogens and stress conditions. Several allelochemicals such as flavanols, stilbenes, and quinones were identified in the extracts, residues, and rhizosphere soil of the knotweeds. The accumulated evidence suggests that some of those allelochemicals in knotweeds may be released into the rhizosphere soil through the decomposition process of their plant parts, and the exudation from their rhizomes and roots. Those allelochemicals may inhibit the germination and growth of native plants, and suppress the mycorrhizal colonization of native plants, which provides the knotweeds with a competitive advantage, and interrupts the regeneration processes of native plants. Therefore, allelopathy of knotweeds may contribute to establishing their new habitats in the introduced ranges as invasive plant species. It is the first review article focusing on the allelopathy of knotweeds.
A Comprehensive CFD Assessment of Wheat Flow in Wheat Conveying Cyclone Validation and Performance Analysis by Experimental Data
Authors: Dizajyekan Sajed Naiemi , Shahgholi Gholamhossein , Rezvanivand Fanaei Adel , Rostampour Vahid , Sharabiani Vali Rasooli , Szymanek Mariusz , Marczuk Andrzej
Published: December 2021

Cyclone is often used in the Industry due to its low maintenance costs, simple design, and ease of operation. This work presents both experimental and simulation evaluation on the effect of inlet velocity and mass flow rate on the performance of a wheat conveying cyclone. According to the great importance of the pressure drop and separation efficiency on the separation phenomenon in the cyclone, a comprehensive study has been conducted in this regard. A computational fluid dynamics (CFD) simulation was realized using a Reynolds stress turbulence model, and particle-air interactions were modeled using a discrete phase model. The result showed a good agreement between the measured value and CFD simulation on the pressure drop and tangential velocity with a maximum deviation of 6.8%. It was found that the separation efficiency increased with inlet velocity up to 16 m s−1 but decreased slightly at a velocity of 20 m s−1. The pressure drop increased proportionally with inlet velocity. However, optimum performance with the highest separation efficiency (99%) and acceptable pressure drop (416 Pa) was achieved at the inlet velocity of 16 m s−1 and mass flow rate of 0.01 kg s−1.