bluuebunny/crossref_metadata_2025 huggingface dataset:
The Efficacy of Multi-Period Long-Term Power Transmission Network Expansion with Penetration of Renewable Sources
Authors: Nnachi Gideon Ude , Hamam Yskandar , Richards Coneth Graham
Published: July 2023

Electrical energy demand increase does evolve rapidly due to several socioeconomic factors such as industrialization, population growth, urbanization and of course the evolution of modern technologies in this 4th industrial revolution era. Such rapid increase in energy demand introduces a huge challenge in power system. Such has paved way for network operators to seek for alternative energy resources other than the conventional fossil fuel system. Hence, the penetration of renewable energy into the electricity supply mix has evolved rapidly in the past three decades. However, the grid system has to be well planned ahead to accommodate such increase in energy demand in the long run. Transmission Network Expansion Planning (TNEP) is a well ordered and profitable expansion of power facilities that meets the expected electric energy demand with an allowable degree of reliability. This paper proposes a TNEP model that minimises the network reinforcements, operational costs and costs of renewable energy penetrations, while satisfying the increase in demand. The problem is formulated as a mixed integer linear programming (MILP) problem. The developed model has been tested in several IEEE test systems in multi-period scenarios. The paper also carried out a detailed derivation of the new non-negative variables in terms of the power flow magnitudes, the bus voltage phase angles and the lines’ phase angles for proper mixed integer variables’ decomposition techniques. Moreover, this paper tends to provide additional recommendation in terms of which particular year (within 20 years of planning period) can the network operators install new line(s), new corridor(s) and/or additional generation capacity to the respective existing power networks. Such is achieved by running incremental periods simulations from base year through the planning horizon. The results show the efficacy of the developed model in solving the TNEP problem with a reduced and acceptable computation time even for large power grid system.
Microbial Biofertilisers in Plant Production and Resistance: A Review
Authors: Prisa Domenico , Fresco Roberto , Spagnuolo Damiano
Published: July 2023

To identify soil microbial communities, it is essential to understand their phenotypic and genetic characteristics. Plant growth-promoting rhizobacteria (PGPR) are bacteria capable of promoting plant growth. In addition, rhizobacteria also serve as biological control agents. In addition to fixing atmospheric nitrogen, solubilising insoluble phosphate and secreting hormones such as indoloacetic acid, kinetics and gibberellins, plant growth-promoting rhizobacteria help plants grow directly. Furthermore, they facilitate plant growth indirectly by inducing systemic resistance, siderophores, antibiotics, lytic enzymes, hydrogen cyanide production and stress regulation. This review examines in detail the direct and indirect mechanisms of PGPR action and their interaction in plant growth and resistance.
Performance Optimization of Carboxymethyl Chitosan-Gelatin- Based Edible Coating and Its Preservation Effect on Sweet Cherries
Authors: Zhang Yu-Lei , Cui Qing-Liang , Wang Yu , Liu Jin-Long , Zhang Yan-Qing
Published: July 2023

To prepare an edible coating with a good preservative effect on sweet cherries, carboxymethyl chitosan (CMCS) and gelatin (GL) were selected as the film-forming matrix in this experiment, and CaCl2 and ascorbic acid (AA) were added as crosslinking agents and antioxidants, respectively. First, the film was prepared by the casting method, and the film formula with better mechanical and barrier performance was filtered out by one-factor and response surface optimization test, and the differences in the preservation effect of different film formulations (CMCS-GL, CaCl2- CMCS-GL, AA -CaCl2- CMCS-GL) on sweet cherries were compared. and then the different film formulations were compared. The difference in film formulation on the preservation effect of sweet cherries was investigated. The results showed that the optimal formulation for an edible film based on CMCS-GL with good performance was CMCS: GL (w:w)=2:1, with the additional amount of 1% glycerol, 2% CaCl2, 0.1% Tween-20, 2% AA, the tensile strength, elongation at break, oxygen permeability and water vapor permeability of the film obtained with this formula were: 16.28 MPa, 71.46%, 1.39×10-12 g- cm/(cm2-s-Pa), 5.10×10-11 cm3-cm/(m2-s-Pa), respectively. In the preservation of sweet cherries, all three film formulations effectively reduced the rotting rate and weight loss during storage while preserving the high hardness and skin color of the fruit. Among them, the formulation AA -CaCl2- CMCS-GL showed the best preservation effect and can be used as a new method for postharvest preservation of sweet cherries.
Human PBMCs Form Lipid Droplets in Response to Spike Proteins
Authors: Sivaraman Kokilavani , Pino Paco , Raussin Guillaume , Anchisi Stephanie , Metayer Charles , Dagany Nicolas , Held Julia , Wrenger Sabine , Welte Tobias , Wurm Maria J , Wurm Florian M , Olejnicka Beata , Janciauskiene Sabina
Published: July 2023

Intracellular lipid droplets (LDs) can occur in response to inflammation, metabolic stresses, and other physiological/pathological processes. Herein, we investigated whether spike proteins of SARS-CoV-2 induce LDs in human peripheral blood mononuclear cells (PBMCs) and in pulmonary microvascular endothelial cells (HPMEC). PBMCs or HPMEC were incubated alone or with endotoxin-free recombinant variants of trimeric spike glycoproteins (Alpha, Beta, Delta, and Omicron, 12 µg/ml). Afterwards, cells were stained with Oil Red O for LDs, cytokine release was determined by ELISA, and the gene expression was analyzed by real-time PCR using TaqMan assays. Our data show that spikes induce LDs in PBMCs but not in HPMEC. In line, in PBMCs spike proteins lower expression of genes involving lipid metabolism and LDs formation, such as SREBF1, HMGCS1, LDLR, and CD36. On the other hand, PBMCs exposed to spikes for 6 or 18 h did not increase in IL-1β, IL-6, IL-8, MCP-1, and TNFα release or expression as compared to non-treated controls. Thus, spike-induced LDs formation in PBMCs seems to be not related to cell inflammatory activation. Further detailed studies are warranted to investigate in which specific immune cells spikes induce LDs, and what are pathophysiological mechanisms and consequences of this induction in vivo.
Comparative Study of Magnetic Properties of (Mn$_{1-x}$A$_x^{IV}$)Bi2Te4 A$_x^{IV}$ = Ge, Pb, Sn
Authors: Estyunin Dmitry A. , Rybkina Anna A. , Kokh Konstantin A. , Tereshchenko Oleg E. , Likholetova Marina V. , Shikin Alexander M.
Published: July 2023

We investigated the magnetic properties of antiferromagnetic (AFM) topological insulator MnBi$_2$Te$_4$ with partial substitution of Mn atoms by non-magnetic elements (A$_x^{IV}$ = Ge, Pb, Sn). Samples with various element concentrations (10-80%) were studied using SQUID magnetometry. The results demonstrate that, for all substitutes the type of magnetic ordering remains AFM, while the Nèel temperature (T$_N$) and spin-flop transition field (H$_{SF}$) decrease with increasing A$_x^{IV}$ = Ge, Pb, Sn concentration. The rate of decrease varies among the elements, being highest for Pb, followed by Sn and Ge. This behavior is attributed to combined effects of magnetic dilution and lattice parameter increase on magnetic properties, most prominent in (Mn$_{1−x}$Pb$_x$)Bi$_2$Te$_4$. Besides this, the linear approximation of experimental data of T$_N$ and H$_{SF}$ suggests higher magnetic parameters for pure MnBi$_2$Te$_4$ than observed experimentally, indicating the possibility of their non-monotonic variation at low concentrations and the potential for enhancing magnetic properties through doping MnBi$_2$Te$_4$ with small amounts of nonmagnetic impurities. Notably, the (Mn$_{1−x}$Pb$_x$)Bi$_2$Te$_4$ sample with 10% Pb substitution indeed exhibits increased magnetic parameters, which is also validated by local analyses using ARPES. Our findings shed light on tailoring the magnetic behavior of MnBi$_2$Te$_4$-based materials, offering insights for potential applications in device technologies.
Measurement of Mechanical Behavior of 11B Enriched MgB2 Wire Using Pulsed Neutron Source
Authors: Machiya Shutaro , Osamura Kozo , Hishinuma Yoshimitsu , Taniguchi Hiroyasu , Harjo Stefanus , Kasawaki Takuro
Published: July 2023

MgB2 is a hexagonal superconducting material, and its simple composition has led to the development of low-cost practical wires. However, the problem is that the strain characteristics of filaments are inferior to those of other practical wires, but there have been no strain measurements using diffraction method. The reason for this is presumably that it is a little too thick for synchrotron radiation measurements, and the large absorption cross section of the included boron-10 makes it difficult to obtain elastic scattering for neutron measurements. We prepared a wire substituted with boron-11, an isotope with small neutron absorption cross section, and attempted to measure its strain under tensile loading using pulsed neutron.
Haircut Capital Allocation as Solution of a Quadratic Optimization Problem
Authors: Belles-Sampera Jaume , Guillen Montserrat , Santolino Miguel
Published: July 2023

The capital allocation framework proposed by [] presents capital allocation principles as solutions to particular optimization problems and provides a general solution of the quadratic allocation problem via a geometric proof. However, the widely used haircut allocation principle is not reconcilable with that optimization setting. In this paper we provide an alternative proof of the quadratic allocation problem based on the Lagrange multipliers method to reach the general solution. We show that the haircut allocation principle can be accommodated to the optimization setting with the quadratic optimization criterion if one of the original conditions is relaxed. Two examples are provided to illustrate the accommodation of this allocation principle.
Revolutionizing Early Disease Detection: A High-Accuracy 4D CNN Model for Type 2 Diabetes Screening in Oman
Authors: Al Sadi Khoula Ali , Balachandran Wamadeva
Published: July 2023

Abstract: The surge of diabetes poses a significant global health challenge, particularly in Oman and the Middle East. Early detection of diabetes is crucial for proactive intervention and improved patient outcomes. This research leverages the power of machine learning, specifically, Convolutional Neural Networks (CNNs), to develop an innovative 4D CNN model dedicated to early diabetes prediction. A region-specific dataset from Oman is utilized to enhance health outcomes for individuals at risk of developing diabetes. The proposed model showcases remarkable accuracy, achieving an average accuracy of 98.49% to 99.17% across various epochs. Additionally, it demonstrates excellent F1 score, recall, and sensitivity, highlighting its ability to identify true positive cases. The findings contribute to the ongoing effort to combat diabetes and pave the way for future research in using deep learning for early disease detection and proactive healthcare.
Toward a Distinction between VisualWord Recognition and Reading, a New Paradigm
Authors: Rami Younes , laanaya Hicham , Bdouh Hassan , Badaoui Bouabid
Published: July 2023

Reading is a complex cognitive task involving processes from different systems. The present work aims to identify some points of divergence reported in the reading literature and discuss them in a new experimental paradigm framework. Inspired by the paradigms of perceptual identification and rapid parallel presentation (RPVP), we emphasize that the originality of our experimental paradigm lies in the recruitment of multi-stable Arabic percepts within the region where low-level processing occurs (i.e., the visual span area). With good flexibility, the current paradigm has reached higher-order processing levels. In agreement with previous works highlighting the parafoveal-on-foveal effect, results suggest parallel word processing. Furthermore, they suggest a rapid extraction of syntactic and semantic information from words in sentences while attributing an advantage to semantic processing in the emergence of the sentence superiority effect.
Improvements in Cybersecurity: Coupling Python for Digital
Forensics
Authors: Abdulhameed Abbas Abdulazeez , Hussien Nadia Mahmood , Mohialden Yasmin Makki , Herlem Guillaume , LAJOIE Isabelle , YAHIAOUI Réda
Published: July 2023

This article delves deeply into digital forensics, covering computer forensics, network 1
forensics, and mobile device forensics. It analyzes the techniques and methodologies used by forensic 2
investigators in various disciplines. It underlines the diffculties investigators encounter and the 3
importance of thorough investigations to combat ever-increasing cyber risks. The paper emphasizes 4
the necessity of leveraging digital forensic tools to improve cybersecurity and provides a thorough 5
list of widely used Python libraries suitable for each investigation strategy, allowing for effective 6
comparison. Furthermore, it emphasizes the availability and suitability of these Python libraries in 7
computer device investigations (PyTSK3, Volatility, Pyregf, and Pyevtx), mobile device investigations 8
(Pytsk3, Volatility, Pyewf, dfVFS, Androguard, and pyMobileDevice), and network forensics (Scapy, 9
Bro/Zeek, Dpkt, pypcap, and NetworkX). The creation of these libraries recognizes the complexities 10
of digital crimes and the importance of applying modern techniques in forensic investigations. 11
Particularly, digital forensics plays an important role for healthcare providers because modern 12
medical devices produce, store, and transmit large amounts of patient and therapy information, 13
which could provide a forensic investigator with a treasure trove of potential digital evidence.
Horizontal Ridge Augmentation with Porcine Bone-derived Grafting Material: A Long-Term Retrospective Clinical Study with More Than 5 Years of Follow-Up
Authors: Choi Jin-Won , Hwang Soo-Shin , Yun Pil-Young , Kim Young-Kyun
Published: July 2023

The purpose of this study was to evaluate the outcomes of implants placed in horizontally augmented alveolar ridges using porcine bone grafts and to investigate the long-term stability of the porcine bone grafts. A retrospective analysis was conducted on 55 sites that underwent horizontal ridge augmentation using porcine bone grafts and implant placement with a follow-up period longer than 5 years. Furthermore, additional analysis was conducted on 24 sites where porcine bone grafts were used exclusively and implants were placed simultaneously with horizontal ridge augmentation. The mean follow-up period after prosthesis loading was 67.3 months, with a mean marginal bone loss of 0.18 mm at 1 year and a cumulative mean marginal bone loss of 0.37 mm over the entire follow-up period. Of the 55 implants, 2 were lost and 4 did not meet the success criteria, resulting in a survival rate of 96.4% and a success rate of 89.1%. In 24 sites, the mean marginal bone loss was 0.22 mm at 1 year and 0.40 mm at 65.8 months, with 100% survival and success rates. Porcine bone grafts can be successfully used in horizontal ridge augmentation for implant placement in cases of ridges with insufficient horizontal width.
A Mathematical Population Growth Model for Urban Water Security Management and Sustainability in Cities (Case Study: Tabriz City)
Authors: Imani Saeed , Dinpashoh Yagob , Asadi Esmail , Fakheri Ahmad
Published: July 2023

In this research, a new conceptual framework introduced to analysis of water security. Using the exponential, logistic growth model, and employing the historical population of Tabriz city from 1956 to 2016, the future period (2022-2100) population predicted. Pearson Correlation, Spearman's Rho and Kendall's rank coefficients were used for analyzing correlation between population and water consumption. In addition, the amount of city water demand in the future period predicted using the ordinary least square model. Then, water stress and water scarcity indices calculated for Tabriz city in the future period. Results indicated that the mathematical population growth models are very suitable for prediction of city population. There was a significant positive correlation between the city population and water demand. In addition, the amount of water demand will proportionally increase with rising number of population. Finally, linear and quadratic equations presented for city water demand based on the city population number. It can be concluded that Tabriz city will be faced with severe water stress in the future period. The proposed new method in this study can be used for other different cities of the world. Also, Results will be helpful for decision makers in optimum management of urban water resources.
Z-Ligustilide Combined with Cisplatin Reduces PLPP1-Mediated Phospholipid Synthesis to Impair Cisplatin Resistance in Lung Cancer
Authors: Geng Pengyu , Zhao Jinhui , Li Qi , Wang Xiaolin , Qin Wangshu , Wang Ting , Shi Xianzhe , Liu Xinyu , Chen Jia , Qiu Hongdeng , Xu Guowang
Published: July 2023

Z-ligustilide is a main active ingredient in the volatile oil of Angelica sinensis, a traditional Chinese medicine. Cisplatin is a commonly used chemotherapy drug for the treatment of lung cancer. Efficacy is often limited by the development of drug resistance after long-term treatment. Here, we investigated the effect of the combination of Z-ligustilide and cisplatin (Z-ligustilide+cisplatin) on resistance of cisplatin-resistant lung cancer cells and its action mechanism. Cell viability was analyzed by cell counting kit-8 (CCK-8) assay. Cell cycle and cell apoptosis were examined by flow cytometry assay. mRNA and protein levels of factors related to cell cycle and apoptosis were analyzed by real-time PCR and western blot. Liquid chromatography-mass spectrometry (LC-MS) analysis and RNA sequencing in A549, A549/DDP and A549/DDP cells treated with the Z-ligustilide+cisplatin were performed. The expression of PLPP1 was analyzed by the Cancer Genome Atlas (TCGA). The correlation between PLPP1 and prognosis was evaluated by immunohistochemistry and Kaplan-Meier (KM) plotter analysis. We found that Z-ligustilide+cisplatin could decrease the cell viability of cisplatin-resistant lung cancer cells. Z-ligustilide+cisplatin induced cell cycle arrest, and promoted cell apoptosis of cisplatin-resistant lung cancer cells. Metabolomics combined with transcriptomics revealed that Z-ligustilide+cisplatin inhibited phospholipid synthesis by upregulating the expression of PLPP1. Furthermore, PLPP1 expression was positively correlated with good prognosis. Knockdown of PLPP1 abolished the effects of Z-ligustilide+cisplatin on cell cycle and apoptosis. Z-ligustilide+cisplatin inhibited the activation of AKT by reducing the levels of PIP3 levels. Z-ligustilide+cisplatin induced cell cycle arrest and promoted cell apoptosis of cisplatin-resistant lung cancer cells by inhibiting PLPP1-mediated phospholipid synthesis.
A Brief Report of Copper and Lead Stabilization in Mine Tailings Using Lycium chilense and Haplopappus foliosus
Authors: Lazo Andrea , Lazo Pamela , Gutierrez Claudia , Hansen Henrik , Ortiz Rodrigo
Published: July 2023

: In Chile, most tailings impoundments are in Northern and Central Chile, 20% of them are abandoned. Municipal budgets to manage these environmental liabilities are very limited and the use of native and endemic plant species to remove heavy metals from tailings is a low-cost alternative. Ex-situ phytoremediation experiments were conducted over seven months to evaluate the potential of Lycium chilense and Haplopappus foliosus to remove copper and lead from mine tailings. The results indicate that both species can concentrate high levels of both elements and they present removal efficiencies for Cu close to 50%. The best performance was presented by Haplopappus foliosus, accumulating higher concentrations of both metals than Lycium chilense. Also, it presents a bioconcentration over 1.
Delayed Orbital Floor Reconstruction Using a Mirroring Technique and patient-specific implants: a prospective clinical study.
Authors: D'Alpaos Diana , Badiali Giovanni , Ceccariglia Francesco , Tarsitano Achille
Published: July 2023

Enophthalmos is a severe complication of primary reconstruction following orbital floor frac-tures, oncological resections or maxillo-facial syndromes. The goal of secondary reconstruction is to re-store symmetrical globe positions to recover function and aesthetics. In this article we pre-sent a method of computer-assisted orbital floor reconstruction using a mirroring technique and a customized titanium or high-density polyethylene mesh, printed using computer aided manufac-turing techniques.
This reconstructive protocol involves 4 steps: mirroring of the healthy orbit at the affected site, vir-tual design of a patient specific orbital floor mesh, computer-assisted manufacturing (CAD) of the implant, and surgical insertion of the device. Using a computed tomography data set, the un-injured side of the craniofacial skeleton was reflected onto the contralateral injured side, and a reconstructive orbital floor prosthesis was virtually designed on the mirrored orbital bone sur-face. The solid-to-layer (.STL) files of the prosthesis were then manufactured using Direct Metal Laser Sintering (DMLS) or Computer Numerical Control (CNC) methods, leading to the produc-tion of 10 titanium meshes and 2 high density polyethylene (HDPE) implants.
Clinical outcomes were assessed using 3dMD photogrammetry and computed tomography measures in 14 treated patients.
The technique described here appears to be a viable method to correct complex orbital floor de-fects needing delayed reconstruction. This article represents the prosecution of a previous study, which is part of a wider experimental protocol for orbital floor reconstruction using comput-er-assisted design-computer-assisted manufacturing (CAD-CAM) technology
Does Asthma Disrupts Psychological Wellbeing in Pregnancy?
Authors: Fernández-Paredes Paola C. , Morales Eva , Lopez-Soler Concepción , Garcia-Marcos Luis
Published: July 2023

Background: Asthma is a very prevalent disease with special characteristics during pregnancy, however little is known about its relation to the psychological wellbeing of women in this period; We aimed to know whether depression and anxiety symptoms are more frequent in asthmatic pregnant women. (2) Methods: Family Apgar (week 20), Edinburgh (weeks 20 and 32) and STAI (week 32) tests were administered to 738 pregnant women (81 asthmatics) in the NELA birth cohort; (3) Results: There were no significant differences between asthmatic and non-asthmatic pregnant women in any of the different tests at any of the time points. The mean? scores for the different tests and timepoints between asthmatic and non-asthmatic pregnant women were: Apgar 20, 17.9±2.2 vs. 10.0±2.2; Edinburgh 20, 6.7±4.2 vs. 6.9±4.3; Edinburgh 32, 5.9±4.4 vs. 5.6±4.3; and STAI 32, 16.7±8.4 vs. 15.8±8.3. The proportion of pregnant women out of the normal range score for any of the tests and time points was also similar in both populations. (4) Conclusions: Asthma is not associated with the psychological wellbeing among pregnant women.
COVID-19 Infection during Pregnancy: Disruptions in Lipid Metabolism and Implications for Newborn Health
Authors: Frankevich Natalya A. , Tokareva Alila , Chagovets Vitaliy V. , Starodubtseva Natalia , Dolgushina Natalia V. , Shmakov Roman G. , Sukhikh Gennady T. , Frankevich Vladimir E.
Published: July 2023

The COVID-19 pandemic has raised questions about indirect impact in pregnant women on the development of their future children. Investigating the characteristics of lipid metabolism in the "mother-placenta-fetus" system can give information about the pathophysiology of COVID-19 infection during pregnancy. 234 women were included in study. Maternal plasma, cord blood, amniotic fluid lipidome were analyzed using HPLC-MS/MS. Differences in lipid profile were searched by Manna-Whitney and Kruskall-Wallis test, diagnostic model based on logistic regres-sion were bilt by AIC. Elevation levels of lysophospholipids, triglycerides, sphingomyelins, and oxidized lipids was registered in patients’ after COVID-19 maternal and cord plasma. An increase in maternal plasma sphingomyelins and oxidized lipids was observed in cases of infection during the second trimester. In amniotic fluid, compared to the control group, nine lipids are reduced, six lipids are elevated. Levels of phosphoglycerides, lysophosphoglycerides, and phosphatidylinosi-tols decreased during infection in the second and third trimesters of pregnancy. Newborn’s health diagnostic model based on maternal plasma were developed for each group and exhibit good di-agnostic value (AUC> 0.85). Maternal and cord plasma’s lipidome changes during delivery, asso-ciated with Covid-19 infection during pregnancy, are synergistic. The most significant disturbances occur with infections in the second trimester of pregnancy.
N-acetyl-L-Glutamate Kinase of Chlamydomonas reinhardtii: In Vivo Regulation by PII Protein and Beyond
Authors: Vlasova Vitalina , Lapina Tatiana , Statinov Vladislav , Ermilova Elena
Published: July 2023

N-Acetyl-L-glutamate kinase (NAGK) catalyzes the rate-limiting step in the ornithine/arginine biosynthesis pathway in eukaryotic and bacterial oxygenic phototrophs. NAGK is the most highly conserved target of the PII signal transduction protein in Cyanobacteria and Archaeplastida (red algae and Chlorophyta). However, yet there is still much to be learnt on how NAGK is regulated in vivo. The use of unicellular green Chlamydomonas reinhardtii as a model system has already been instrumental in identifying several key regulation mechanisms that control nitrogen (N) metabolism. With a combination of molecular-genetic and biochemical approaches, we show the existence of the complex CrNAGK control at transcriptional level, which is dependent on N source and N availability. In growing cells, CrNAGK requires CrPII to properly sense the feedback inhibitor arginine. Moreover, we provided primary evidence that CrPII is only partly responsible for regulating CrNAGK activity to adapt to changing nutritional conditions. Collectively, our results suggest that in vivo CrNAGK is tuned at transcriptional and post-translational levels, and CrPII and additional as yet unknown factor(s) are integral parts of this regulation.
FEA of Infilled Composite Beam Using Angle Type Shear Connector
Authors: Lee Jun Seop , Woo Jong Hun , Shin Kyung Jae , Lee Hee Du
Published: July 2023

A composite beam is a structural member that behaves as a single unit by using shear connectors between a concrete slab and an H-shaped steel girder. The composite ratio is crucial and determined by the shear connectors' ability to withstand the horizontal shear forces between the concrete and steel girder. In this study, a U-shaped composite beam was designed, which differs from conventional composite beams as it allows the use of a steel girder as a formwork. Moreover, angle-type shear connectors, instead of stud-type connectors, were employed. Based on this design, large-scale U-shaped composite beams with angle-type shear connectors were fabricated, and load tests were conducted to analyze the behavior after composite action and the influence of shear connector spacing. Additionally, the strength of the angle-type shear connectors used in this paper was evaluated through finite element analysis. Finally, a strength evaluation method for composite beams of this configuration was proposed.
Synthetic Mueller imaging polarimetry
Authors: Gil José J. , José Ignacio San
Published: July 2023

The transformation of the state of polarization of a light beam by its linear interaction with a material medium can be modeled through the Stokes-Mueller formalism. The Mueller matrix associated with a given interaction depends on many aspects of the measurement configuration. In particular, different Mueller matrices can be measured for a fixed material sample depending on the spectral profile of the light probe. For a given light probe and a given sample with inhomogeneous spatial behavior, the polarimetric descriptors of the point-to-point Mueller matrices can be mapped leading to respective polarimetric images. The procedure can be repeated sequentially by using light probes with different central frequencies. In addition, the point-to-point Mueller matrices consecutively measured can be combined synthetically through convex sums leading to respective new Mueller matrices, in general with increased polarimetric randomness, thus exhibiting specific values for the associated polarimetric descriptors, including the indices of polarimetric purity, and generating new polarimetric images which are different from those obtained from the original Mueller matrices. In this work, the fundamentals for such synthetic generation of additional polarimetric images are described, providing a new tool that enhances the exploitation of Mueller polarimetry.
The Role of Cysteine Peptidases Cathepsins B, H, C, and X/Z in Neurodegeneration and Cancer
Authors: Stoka Veronika , Vasiljeva Olga , Nakanishi Hiroshi , Turk Vito
Published: July 2023

Papain-like lysosomal cysteine proteases include 11 human cysteine cathepsins which act as endopeptidases and/or exopeptidases. They are involved in numerous physiological and pathological processes. Among them, only cathepsins B, H, C, and X/Z exhibit exopeptidase activity. Their activities are tightly regulated in various ways to prevent potentially hazardous effects on the cell. In this review, we focus on the structural and functional aspects of these four cysteine cathepsins and their role in neurodegeneration and cancer.
Neurodegenerative disorders of aging share an endolysosomal dysfunction and accumulation and spread of oligomeric forms of neurotoxic proteins. The accumulation of various protein aggregates activates the microglia, thus inducing the activation and release of cysteine cathepsins and proinflammatory cytokines, leading to neurodegeneration.
In cancer, cysteine cathepsins participate in tumor progression and metastasis. Tumor–stromal crosstalk leads to activation of the stroma and overexpression and secretion of proteolytic enzymes, triggering extracellular matrix degradation and the release of soluble factors. Activated stromal cells (i.e., macrophages, fibroblasts, mast cells) secrete additional growth factors, cytokines, and chemokines that are responsible for the regulation of processes leading to tumor progression and metastasis. Therefore, a better understanding of the role of cysteine cathepsins in neurodegeneration and cancer could lead to novel targeted therapeutic approaches.
Indoor Air Contamination by Yeasts in Healthcare Facilities: Risks of Invasive Fungal Infection
Authors: Nascimento Jean Phellipe Marques do , Santos Raniele dos , Silva Mirna Samile dos Santos , Araújo Mykaella Andrade de , Anhezini Lucas , Santos Daniela Évelin dos , Silva-Filho Eurípedes Alves da
Published: July 2023

Background: Fungi are ubiquitous microorganisms that are easily dispersed through the air. In healthcare environments, indoor air can favor the spread of healthcare-associated fungal infections, compromising mainly immunocompromised hospitalized individuals. Thus, this study aimed to evaluate the indoor air contamination in healthcare environments, investigating mainly the presence of potentially pathogenic yeasts. Methods: Indoor air samples were collected from twelve healthcare environments (hospital and medical clinics). After the growth, isolation, and purification of the yeast colonies, the isolates were identified by polymerase chain reaction using species-specific primers for yeasts of the genus Candida and sequencing of D1/D2 domains of the large ribosomal subunit (LSU rRNA). Results: Fourteen yeast species were identified, including emerging pathogens. Species of clinical importance such as Candida parapsilosis, Candida orthopsilosis, Candida glabrata, Rhodotorula mucilaginosa, and Trichosporon mucoides were present. C. Parapsilosis was the most prevalent species, followed by Rodothorula mucilaginosa. Conclusions: The present study shows that potentially fungal pathogens were present in air samples from healthcare environments, proving the role of indoor air in spreading infections. Thus, monitoring air quality in healthcare environments is a fundamental approach in developing infection control measures, especially those related to invasive fungal infections.
O lugar do ensino de História nas licenciaturas em História no Brasil: saberes, reflexões e desafios
Authors: Cavalcanti Erinaldo
Published: July 2023

O artigo analisa quais saberes são mobilizadosnas disciplinas obrigatórias voltadas,especificamente, ao Ensino deHistória, em 27 Projetos Políticos Pedagógicos(PPPs), por meio de 83 componentescurriculares. Como metodologia,recorreu-se aos procedimentos quantitativospelos quais se catalogou quantase quais disciplinas compõem a amostra,sua carga horária e sua distribuição nosarranjos curriculares. Em seguida, procedicom a análise qualitativa, problematizandoquais saberes são indicadosnas disciplinas. Pela análise, percebe-seque, mesmo existindo uma variedade deformas, sentidos e saberes acerca do ensinode História, esse é apresentado,fundamentalmente, como sendo uma“questão de metodologia”.
O ensino de história ambiental na educação básica: uma Aula-Oficina sobre a “pré-história”
Authors: Nascimento Evandro Cardoso do
Published: July 2023

Este artigo apresenta resultados de umainvestigação sobre o ensino de históriaambiental na educação básica. A investigaçãopartiu de reflexões do campo dahistória ambiental e da educação históricapara realizar uma prática pedagógicacom estudantes do 6º ano, do EnsinoFundamental, de duas escolas públicasde Paranaguá-PR. A metodologia utilizadafoi a Aula-Oficina, em que pinturasrupestres, do Parque Nacional Serrada Capivara, foram utilizadas como fontespara a reconstrução dos ambientesnaturais do passado e discussão sobre asmudanças climáticas. Partindo da teoriada consciência histórica de Jörn Rüsen(2001), a investigação revela que os estudantesdesenvolveram a percepção deque o ambiente não é estático e concluique a consciência histórica do tipo genéticapassa pela compreensão de que asexperiências humanas no tempo nãoocorrem sem interação com o mundonatural.
Literatura sensível, história extra-humana: reflexões sobre os sujeitos no currículo e no ensino de História
Authors: Florianovitch Lucas , Ribeiro Junior Halferd Carlos
Published: July 2023

O presente artigo pretende abordar as conexões e contribuições entre literatura e ensino de história, para com isso refletir sobre as potencialidades didáticas dos usos da literatura no processo de ensino de história. A partir da crítica à história extra-humana contida na BNCC, realizou-se a analise das obras Machado de Assis, historiador e Quarto de despejo para exemplificar as contribuições da literatura na construção de um ensino de história sensível ao tratarmos de temas como a escravidão e desigualdade social. Constatou-se que, apesar do longo diálogo entre literatura e história, as propostas de currículo e ensino de história vigentes continuam a negar e a não incorporar os aspectos sensíveis e empáticos, contidos na narrativa literária, ao tratar dos sujeitos históricos. Assim, buscou-se elucidar a fundamentalidade do diálogo com a literatura na (re)construção das formas de entender, pensar e ensinar história na sala de aula
Qual o lugar da educação libertadora no ensino de História? A presença do pensamento de Paulo Freire na revista História & Ensino.
Authors: Belieiro Thiago Granja
Published: July 2023

O artigo coloca o campo de conhecimento sobre ensino de História como objeto de pesquisa da História da Historiografia, inserindo a produção sobre ensino de História como parte integrante da Historiografia Brasileira, investigando esse campo dentro da analítica da historicidade. Para isso, elege como fonte de pesquisa os artigos publicados na revista História & Ensino, importante periódico do campo, que desde 1995 publica artigos quase exclusivamente voltados a essa temática. Investiga especificamente os usos da produção teórica do educador Paulo Freire na revista, no período compreendido entre 1995 a 2020, com análise quantitativa e qualitativa da presença de Paulo Freire na publicação e consequentemente no campo de produção de conhecimento em ensino de História.
O ensino de História no Boletim do Historiador da ANPUH-SP (1990-2002)
Authors: Giavara Ana Paula , Barreiro Iraíde Marques de Freitas
Published: July 2023

Ao longo de sua trajetória, a Associação Nacional de História – ANPUH e seus Núcleos Regionais consagraram-se como espaços de diálogo sobre temas relevantes para o profissional e o professor de História. No âmbito paulista, estes debates acontecem em seminários e grupos de pesquisa, em encontros bianuais, em periódicos, bem como ocorreram no Boletim do Historiador, publicação periódica informativa da ANPUH – São Paulo, cuja circulação se deu entre os anos de 1990 e 2002. A partir dessa percepção, este artigo objetiva apresentar a maneira como o Boletim do Historiador foi se constituindo como espaço de reflexões e posicionamentos da comunidade anpuhana sobre a História como disciplina escolar. Além de evidenciar a produtividade e o comprometimento da ANPUH-SP com as questões pertinentes ao ensino, esta investigação também possibilita compreender movimentos e tensões que impactaram a disciplina ao longo da periodicidade descrita.
Diálogos latinoamericanos sobre problemas socialmente vivos. Narrativas y experiencias en contextos de virtualidad
Authors: Jara Miguel Angel
Published: July 2023

Clase Espejo es un dispositivo que posibilitó encuentros -en contexto de aislamiento social provocado por la pandemia- entre profesoras, profesores y estudiantes de los profesorados de ciencias sociales y humanidades de algunas ciudades de Argentina, Brasil, Chile, Costa Rica, Perú y México, para dialogar sobre los problemas socialmente vivos (PSV) en Latinoamérica. Los encuentros se desarrollaron durante los meses de mayo a agosto del año 2021 y contó con una importante participación de jóvenes latinoamericanas y latinoamericanos.
Las narrativas que compartimos en este escrito son algunos semblantes de las diversas actividades desarrolladas en los cuatro encuentros clase espejo y que nos han posibilitado dialogar sobre lo que nos pasa en este continente en este siglo que habitamos. Los PSV sobre los que hemos conversado constituyen una cartografía común en este lugar del mundo.
Pensamento histórico e cultura digital: desafios e experiências na formação de professores
Authors: De Souza Éder Cristiano
Published: July 2023

O presente artigo relata e analisa a experiência do subprojeto da área de História no PIBID (Programa de Bolsas de Iniciação à Docência), desenvolvido entre 2020 e 2022, inicialmente intitulado: “Trabalhando com as TDICs para o ensino e a aprendizagem significativa em História”. O subprojeto, formulado a partir da concepção de aprendizagem significativa, nos direcionou para o desafio de trabalhar com o conceito de pensamento histórico (LEE, 2011; BORRIES, 2011), que conduz à ideia de uma com foco no domínio e na mobilização de determinados princípios, conceitos e operações ligados à construção, representação e usos do conhecimento histórico. Buscou-se explorar essas dimensões a partir de diversas possibilidades educacionais vinculadas à cultura digital (BARATO & CRESPO, 2013) e ao uso das tecnologias digitais de informação e comunicação (TDICs).
O presente artigo relata e analisa a experiência do subprojeto da área de História no PIBID (Programa de Bolsas de Iniciação à Docência), desenvolvido entre 2020 e 2022, inicialmente intitulado: “Trabalhando com as TDICs para o ensino e a aprendizagem significativa em História”. O subprojeto, formulado a partir da concepção de aprendizagem significativa, nos direcionou para o desafio de trabalhar com o conceito de pensamento histórico (LEE, 2011; BORRIES, 2011), que conduz à ideia de uma com foco no domínio e na mobilização de determinados princípios, conceitos e operações ligados à construção, representação e usos do conhecimento histórico. Buscou-se explorar essas dimensões a partir de diversas possibilidades educacionais vinculadas à cultura digital (BARATO & CRESPO, 2013) e ao uso das tecnologias digitais de informação e comunicação (TDICs).
Metodologias ativas, ensino de história e o uso da mídia podcast: mobilizando saberes para além do espaço escolar
Authors: Farias João Paulo de Oliveira , Meneses Sônia
Published: July 2023

O artigo propõem pensar nos desafios que fazem parte do cotidiano do professor, relacionado a um mundo cada vez mais conectado e com acesso à informação; discute a necessidade de integrarmos aparatos tecnológicos enquanto recursos pedagógicos para aulas mais interativas e significativas. Nesse sentido, procura refletir sobre as possibilidades e desafios do uso das novas tecnologias digitais em sala de aula, em especial a viabilidade da produção e difusão de conteúdos históricos, feito com/para os alunos e professores do Ensino Médio através de uma linguagem digital, o podcast. Procuramos com isso fazer uma relação entre educação, o lugar do historiador, do professor e do próprio ensino de história nos dias atuais.
História Medieval no Instagram: relatos iniciais de um experimento em curso (2021-2022)
Authors: Ribeiro Felipe Augusto
Published: July 2023

Este artigo debate o trabalho de um grupo de pesquisa no Instagram: o Elmo. Ele problematiza: a projeção científica nas redes sociais é capaz de ensejar uma construção pública do conhecimento histórico? A discussão é feita em quatro etapas: 1) discussão teórica sobre a relação entre a História Pública e as mídias digitais; 2) descrição do método de trabalho do Elmo, inserido nessa interface; 3) análise dos dados fornecidos pelo “painel profissional” do Instagram; 4) reflexão, a partir dos relatos dos discentes que participam do projeto, sobre como tem sido a experiência de fazer uma pesquisa cujos processos e produtos se desenvolvem majoritariamente em meios digitais. Como resultado, o trabalho formula uma hipótese: o trabalho nas redes sociais serviria mais para a formação dos discentes-pesquisadores do que o público-alvo das postagens.
Comparing the efficacy of meglumine acridon acetate and pentanedioic acid imidazolyl ethanamide in the outpatient treatment for ARVI during the COVID-19 pandemic
Authors:   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Savenkova M.S. , Vetrova E.N. ,   N.F.Gamaleya National Research Centre of Epidemiology and Microbiology, Moscow, Russian Federation, Isaeva E.I. ,   N.F.Gamaleya National Research Centre of Epidemiology and Microbiology, Moscow, Russian Federation, Kraseva G.N. ,   Polyclinic No 2, Clinical and Diagnostic Center of Gazprom, Moscow, Russian Federation, Abramova N.A. ,   Polyclinic No 2, Clinical and Diagnostic Center of Gazprom, Moscow, Russian Federation, Shabat M.B. ,   Polyclinic No 2, Clinical and Diagnostic Center of Gazprom, Moscow, Russian Federation, Dushkin R.V. ,   Artificial Intelligence Agency LLC, Moscow, Russian Federation, Fadeeva S. ,   Artificial Intelligence Agency LLC, Moscow, Russian Federation, Kontio S.V. ,   Artificial Intelligence Agency LLC, Moscow, Russian Federation
Published: July 2023

This study compared the efficacy of different therapies for ARVI during the COVID-19 pandemic. Objective. To compare clinical efficacy of Cycloferon and Ingavirin in children aged 4–17 years treated in outpatient facilities during the epidemic season of СOVID-19. Patients and methods. This study included 101 patients who provided 143 oro- and nasopharyngeal swabs tested using certified PCR tests. Of them, 128 samples (89.5%) were positive, whereas 15 samples (10.5%) were negative. We identified the most common viruses circulating in January–May 2021, including (seasonal) coronaviruses (35.9%), rhinoviruses (20.3%), and other viruses. We also analyzed respiratory viruses that have circulated in Moscow during the last 6 years and found higher levels of seasonal coronaviruses. The most common ARVI symptoms in 2021 were fever, rhinitis, pharyngeal hyperemia, and fatigue. Fewer children had headache, cough, and enlarged lymph nodes. Results. We compared ARVI treatment with broad-spectrum antivirals in children aged between 4 and 17 years. Children in group 1 (n = 51) received Cycloferon®, while children in Group (n = 50) received Ingavirin®. Study participants were diagnosed with ARVI and moderate nasopharyngitis. Children from the Cycloferon group demonstrated a more significant dynamics of such clinical symptoms as headache (p < 0.05), cough (p < 0.01), rhinitis (p < 0.01), abundant mucus (p < 0.001), and enlarged lymph nodes (p < 0.001) than children from the Ingavirin group (there was a significant difference in the duration of these symptoms). Only 2 children from group 1 required antibiotics (3.4%), whereas in group 2, 11 children needed antibacterial therapy (22%). Key words: children, acute respiratory viral diseases (ARVI), COVID-19, PCR diagnostics, clinical manifestations, Cycloferon, Ingavirin
Strengthening Mental Health and Spiritual Survival during the COVID-19 pandemic
Authors: Yuliana Yuliana
Published: July 2023

The COVID-19 pandemic brings significant threats to physical and mental health. Sometimes, mental health is forgotten. However, it is a crucial fact. Less is known about the temporary changes of mental health conditions due to the COVID-19 pandemic. This paper aims to describe the mental problems during the COVID-19 pandemic and how to strengthen the mental health and spiritual survival during the COVID-19 pandemic. This paper is a literature review. The literature was selected from PubMed and Google Scholar. The keywords were COVID-19, mental, spiritual, strengthening. To strengthen mental health, it needs support and strategy. Otherwise, the immune system will be decreased and the coronavirus will be easily infected the body. Sleep disorders, anxiety, depression, and suicide have increased lately. Therefore, it is very essential to strengthen mental health and spiritual survival during the COVID-19 pandemic.
Javanese Maxims as Politeness Guidance in Social Media Phatic Communication: A Cyberpragmatics Perspective
Authors: Widiana Yuli
Published: July 2023

Communication on social media raises at a significant rate during the Covid-19 Pandemic. Social media communication (SMC) in specific culture requires particular strategies related to cultural norms. Due to the limitation of cyber communication compares to direct communication, users of social media utilize available features in social media platforms to perform politeness. The strategies of Javanese netizens to perform Javanese politeness maxims in SMC are the main discussion in this study. The data were collected from five WhatsApp Groups (WAG) of Javanese adults of 20s-40s of age comprising 246 respondents. The conversation texts containing phatic talks in WAG were selected by observation method. Then, the conversational texts and communication icons were transcribed for contextual analysis. The result shows that the Javanese maxims of Kurmat (Respect), Tepa Selira (Tolerance), Andhap Asor (Humility), and Empan Papan (Self-Awareness) were utilized by Javanese netizens in performing politeness in virtual phatic communication. During the pandemic, tolerance maxim is the most frequently used to support each other. The maxim of humility is not obvious in virtual phatic communication. To this extent, Javanese politeness maxims are mitigating devices to establish social rapport in phatic communication. The Javanese ability in performing Javanese maxims as politeness devices is essential to avoid conflict and mitigate Face Threatening Act (FTA) since the Javanese community tends to create harmony in life known as Guyub Rukun.