bluuebunny/crossref_metadata_2025 huggingface dataset:
Natural Autoimmunity to the Thyroid Hormone Monocarboxylate Transporters MCT8 and MCT10
Authors: Porst Theresa , Johannes Jörg , Gluschke Hans , Köhler Richard , Mehl Sebastian , Kuehnen Peter , Renko Kostja , Minich Waldemar B. , Wiegand Susanna , Schomburg Lutz
Published: March 2021

The monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are important for thyroid hormone (TH) uptake and signaling. Reduced TH activity is associated with impaired development, weight gain and discomfort. We hypothesized that autoantibodies (aAb) to MCT8 or MCT10 are prevalent in thyroid disease and obesity. Analytical tests for MCT8-aAb and MCT10-aAb were developed and characterized with commercial antiserum. Serum samples from healthy controls, thyroid patients and young overweight subjects were analyzed, and prevalence of the aAb was compared. MCT8-aAb were additionally tested for biological effects on thyroid hormone uptake in cell culture. Positive MCT8-aAb and MCT10-aAb were detected in all three clinical cohorts analyzed. MCT8-aAb were most prevalent in thyroid patients (11.9%) as compared to healthy controls (3.8%) and overweight adolescents (4.2%). MCT8-aAb positive serum reduced T4 uptake in cell culture in comparison to MCT8-aAb negative control serum. Prevalence of MCT10-aAb was highest in the group of thyroid patients as compared to healthy subjects or overweight adolescents (9.0% versus 4.5% and 6.3%, respectively). We conclude that MCT8 and MCT10 represent autoantigens in humans, and that MCT8-aAb may interfere with regular TH uptake and signaling. The increased prevalence of MCT8-aAb and MCT10-aAb in thyroid disease suggests that their presence may be of pathophysiological relevance. This hypothesis deserves an analysis in large prospective studies.
Hydrogen Technology, a Short Overview
Authors: Charitos Alexander , Makridis Sofoklis Sokratis
Published: March 2021

The Residential and Industrial zones as is, rely heavily, if not exclusively, on Hydrocarbons. Hydrocarbon thermal machinery such as Spark Ignition-Compression Ignition engines, Gasoline-Diesel generators, Coal-Lignite gasifiers, residential diesel-powered heating systems, Pyrolysis units and so on, are commonly met all around the planet. Such technology practically oxidizes Hydrocarbons to produce either heat, steam or useful mechanical work depending on the application, though energy losses are not, by any means, insignificant. Advanced material processing is an industrial sector who’s energy demand is significant and it is important for the general public to come to terms with the fact that by implementing Hydrogen technology to power such plant while at the same time improving the energy equilibrium of houses(advanced materials), communities would be taking major steps towards Climate Change effects debilitation. The downside of Hydrocarbon thermochemical exploitation can be described by the limited resources-reserves and the gaseous pollutant emissions (CO2, CO, NOx, SOx). In recent years, the Industrial zone as a whole has began taking a turn towards Electrification without having established the necessary infrastructure to support such a transition. Indicatively, at current rate of production, dead Lithium-Ion batteries are projected to reach as high as 11,000 metric tons by 2030, yet there is no recycling scheme in place, not to mention the prospect of that number rising even more, given the recent e-mobility trend. As it pertains to Electrification, such powertrains-machinery require electricity and a battery. Electricity production is mainly achieved through Coal-Lignite gasification, Batteries require metals, among others, for manufacturing, meaning that up-on mining, local water resources are contaminated, another very important ‘aspect’ of Lithium(per say) mining is that child labor is often associated with such processes, a truly despicable act. All of the above paint a crystal-clear picture as to how ‘environmentally friendly’ reckless-rushed Electrification really is. Climate Change is up-on us and it’s effects on the planet are obvious, the most important of which is glacier melting due to rising of the global Temperature. The COVID-19 crisis is a sign of what could come from glacier melting could as ice contains potentially harmful-toxic to humans, biological entities that are sure to be introduced to the general public if we were to continue exploiting mineral resources. Purpose of this paper is to provide a general overview of the technology around Hydrogen.
Emerging Evidence on the Effects of Dietary Factors on the Gut Microbiome in Colorectal Cancer
Authors: Appunni Sandeep , Rubens Muni , Ramamoorthy Venkataraghavan , Saxena Anshul , Tonse Raees , McGranaghan Peter , Kaiser Adeel , Kotecha Rupesh
Published: March 2021

Dietary factors play an important role in shaping the gut microbiome which, in turn, regulates the molecular events in colonic mucosa. The composition and resulting metabolism of the gut microbiome have been implicated in the development of colorectal cancer (CRC). Diets low in dietary fibers and phytomolecules as well as other lifestyle-related factors may predispose to CRC. Emerging evidence demonstrates that the predominance of microbes, such as Fusobacterium nucleatum, can predispose the colonic mucosa to malignant transformation. Dietary and lifestyle modifications have been demonstrated to restrict the growth of potentially harmful opportunistic organisms. In this study, we aim to present evidence regarding the relationship of dietary factors to the gut microbiome and development of CRC.
Determinants of Tourist Satisfaction and Dissatisfaction on Tourism Village
Authors: Sari Putri Intan , Lestari Yuliani Dwi
Published: March 2021

Indonesia government established the development of tourism village as one of priority program. Until 2018, there are 1734 tourism villages in Indonesia. However, the increase of tourist visitation is not occurred evenly. Only several tourism villages are having high visitation rate, others are still struggling in competing with other tourism destinations. Previous study found that tourist satisfaction is leading on visit intention. Therefore, this study investigated factors determinant on tourist satisfaction and dissatisfaction of tourism village. A content analysis was adopted in this study by extracting of 464 tourist reviews that posted from January 2016 until October 2019. Data were collected from tourist review on TripAdvisor regarding nine tourism villages in Indonesia. NVivo 12 was used to analyse the data. The results revealed top 5 satisfaction determinant attributes: village landscape, friendliness local people, traditional building, traditional way of life, and village atmosphere. Meanwhile, dissatisfy tourist mention traditional souvenir, village atmosphere, village authenticity, village entrance fee, and the local people who become souvenir seller as the top 5 dissatisfaction attributes.
University Student’s Experiences with Online Synchronous Learning during Covid-19
Authors: Rasto Rasto , Muhidin Sambas Ali , Inayati Tutik , Marsofiyati Marsofiyati
Published: March 2021

This study delivers new insights on students' experiences who have studied their courses at least one semester during the Covid-19 Pandemic. We collected 199 respondents and analyzed the result of the questionnaire. The first finding is that students rather use discussions as a method to conduct online learning in classes. Students also would prefer both methods (asynchronous and synchronous) during online learning. We categorized students' learning experiences into intimacy and connection, supports, coordination and collaboration, technical difficulties, and traits. This study concludes that whole experiences about online synchronous learning did not change, except for the lack of personal support from lecturers when students face difficulties in certain subjects and hardware malfunction during classes. We recommend that lecturers pay more attention to students with less comprehension ability. We also recommend that lecturers run more creative ways other than lecturing in classes and limit lecturing time to decrease boredom.
Development of High-Intensity Focused Ultrasound Therapy for Inferior Turbinate Hypertrophy
Authors: Kim Joon Kon , Cho Sung-Woo , Kim Hyojin , Jo Sung Chan , Kim Hyung Gu , Won Tae-Bin , Kim Jeong-Whun , Lim Jae Hyun , Rhee Chae-Seo
Published: March 2021

Objectives. Inferior turbinate (IT) hypertrophy is the main cause of chronic nasal obstruction. We developed a high-intensity focused ultrasound (HIFU) ablation device to treat patients with IT hypertrophy.Methods. First, computed tomography images of patients with no evidence of sinonasal disease were evaluated to measure and compare the IT, medial mucosal thickness (MT), and space between the nasal septum and IT according to clinical characteristics such as septal deviation. A HIFU prototype was developed based on the above human anatomical studies. The experimental study was performed in five pigs; the nasal volume and histological changes at 1 and 4 weeks postoperatively were evaluated to compare the efficacy of HIFU turbinoplasty with that of radiofrequency turbinoplasty and a control group.Results. The mean medial MT of the anterior, middle, and posterior portions of the IT were 4.66±1.14, 4.23±0.97, and 6.17±1.29 mm, respectively. The mean medial space was 2.65±0.79 mm. The diameter and focal depth of the prototype were 4 mm and 3 mm, respectively. HIFU showed no postoperative complications, including bleeding or scar formation. After HIFU treatment, the nasal volume increased by 196.62 mm3 (7.8%) and 193.74 mm3 (8.3%) at 1 week and 4 weeks, compared with the increase of 87.20 mm3 (3.1%) and 213.81 mm3 (9.0%), respectively,after radiofrequency therapy. A qualitative histological analysis after radiofrequency turbinoplasty showed epithelial layer disruption at 1 week and increased fibrosis, along with decreased glandular structure, at 4 weeks. The HIFU group had an intact epithelial layer at 1 week postoperatively. However, significant differences were observed at 4 weeks, including increased fibrosis and decreased glandular structure.Conclusion. The efficacy and safety of HIFU turbinoplasty were demonstrated in an animal study. Our results warrant further human clinical trials.
Hearing Impairment Increases Economic Inequality
Authors: Kim So Young , Min Chanyang , Yoo Dae Myoung , Chang Jiwon , Lee Hyo-Jeong , Park Bumjung , Choi Hyo Geun
Published: March 2021

Objectives. We evaluated changes in income levels in a hearing-impaired population.Methods. The study subjects were selected from the Korean National Health Insurance Service-Health Screening Cohort data from 2002 to 2015 of Koreans ≥40 years old. In total, 5,857 hearing-impaired subjects were matched with 23,428 comparison participants. Differences between the initial income level and income levels at 1, 2, 3, 4, and 5 years post-enrollment were compared between the hearing-impaired and comparison groups. The interaction of time and hearing impairment/comparison was estimated.Results. Both the hearing-impaired group and the comparison group showed increased income levels over time. In the hearing-impaired group, the income levels at 4 and 5 years post-enrollment were higher than the initial income level (each P<0.001). In the comparison group, the income levels of all the participants after 1–5 years were higher than the initial income level (each P<0.001). The interaction of time and hearing impairment was statistically significant (P=0.021).Conclusion. The increase in income over time was relatively lower in the hearing-impaired adult population; therefore, the income gap widened between this population and the normal-hearing population.
Study of working conditions in aluminum casting shops worksites
Authors: Lazarenkov A. M. , Ivanov I. A.
Published: March 2021

The results of the study of working conditions in aluminum casting shops worksites are presented. The results of these studies showed that in worksites there are exceedance of the permissible limits for noise, vibration, the content of harmful substances in the working environment, intensity of infrared (thermal) radiation and air temperature. There is effect of electromagnetic radiation on the workers during the service of induction furnaces. In addition, the main harmful production factors include the severity of work and the intensity of the labor process. The efficiency of the protective screens of the IAT-6 induction crucible furnace was evaluated.
Performance quality analysis of brake iron and composite pads for railway rolling composition
Authors: Popov E. S. , Shinsky O. I.
Published: March 2021

The requirements for the quality and performance of the brake pads of railway rolling stock made of various materials are analyzed. The advantages of cast iron brake pads produced at foundries are shown. The disadvantages of brake pads made of composite materials based on rubber, asbestos, barite, carbon black and other components are noted. Ways to improve standards, specifications and other documentation for these products are proposed.
Technologies of refining of aluminum alloys by gas blowing
Authors: Sadokha M. A. , Andrushevich A. A.
Published: March 2021

The results of the analysis of various methods of refining aluminum alloys from dissolved gases and non-metallic inclusions are presented. The influence of a number of technological features of each method on the quality of the melt has been studied. Examples of equipment for the implementation of processes are presented. To analyze the effectiveness of the use of various technologies for refining aluminum alloys, their ranking was carried out. The results of the analysis are in correlation with the trends in the spread of various processes for the refining of aluminum alloys in foundries. It is shown that blowing the melt with inert gases through a rotating impeller is the most effective in terms of a set of indicators in comparison with other methods.
Modern technology of investment casting for the production of artistic castings
Authors: Tkachenko S. S. , Emelyanov V. O. , Martynov K. V.
Published: March 2021

The publication describes modern methods of production of fine plastic art castings. The stage of production of the smelted model and development of casting technology is considered. The theoretical basis for obtaining smelted models of a given quality is given. The review of technologies of production of standard castings is presented.
Jordan Higher Bi- Homomorphism and Co- Jordan Higher Bi- Homomorphism on Banach Algebra
Authors: Shaheen Rajaa Chaffat
Published: March 2021

The concepts of higher Bi- homomorphism and Jordan higher Bi- homomorphism have been introduced and studied the relation between Jordan and ordinary higher Bi- homomorphism also the concepts of Co- higher Bi- homomorphism and  Co- Jordan higher Bi- homomorphism introduced  and the relation between them in Banach algebra have also been studied.
PREDICTING THE STATE OF THE ICE BARRIER OF A VERTICAL MINE SHAFT UNDER ARTIFICIAL THAWING
Authors:   Moscow Polytechnic University, KUZINA Alexandra , KRYNKINA Vera ,   Moscow Polytechnic University, MICHEDCHENKO Anatoly ,   LLC “MСC-Shaftproject”
Published: March 2021

At the end of the shaft penetration under the protection of the ice barrier and the termination of the process of freezing the rocks, the transition period from freezing to thawing begins. First of all, the tubing support of the trunk and the layer of rocks adjacent to the concrete support are subjected to thawing. At this time, water is pumped through the grouting holes in the tubing to check the tightness of the tubing column, after which the grouting is performed with cement mortar of the fixed space. Thus, grouting is an integral part of the work on waterproofing the support. For successful work on grouting, it is necessary to ensure the thawing of the ice barrier by a value of 1 m from the contour of the trunk in the sinking. The necessary defrosting can be provided in various ways, including the circulation of warm air in the barrel, the supply of warm coolant to the freezing columns, etc. A program for calculating the defrosting parameters has been developed, depending on the combination of methods for supplying warm air and heated brine. It is determined that in order to create reliable conditions for the production of plugging of the fixing space and water-proofing of the tubing support, the most favorable option is thawing by feeding warm air into the barrel and circulating the coolant at a temperature of +15°C.
ON VARIABILITY OF THE VEGETATION INDEX NDVI IN THE FOOTHILL AREAS OF THE NORTHERN CAUCASUS ACCORDING TO SATELLITE MEASUREMENTS
Authors:   Southern Mathematical Institute of the VSC RAS, KAMENETSKY Evgeniy , RADIONOV Anatoliy ,   Southern Mathematical Institute of the VSC RAS, TIMCHENKO Vasiliy ,   Southern Mathematical Institute of the VSC RAS, PANAETOVA Olga ,   Southern Mathematical Institute of the VSC RAS
Published: March 2021

The study of long-term climatic changes is carried out based on the data of the normalized relative vegetation index NDVI, which is a characteristic of phytobiomass and is used to describe the ecological situation, the amount of contamination and productivity of land. This theoretical work is based on the statistical and mathematical processing of MODIS satellite data (EOS Terra, Aqua), with the help of which the temporal and spatial variations of the NDVI vegetation index for the southern regions of the Russian Federation are studied. Several regions were selected, which located in mountainous or foothill areas on the territory of the North Ossetia-Alania, located in the central part of the North Caucasus. For each region, 20-year data series were obtained, each point of which is the NDVI index averaged over two weeks. With the help of these data series, the annual behavior of the NDVI index and its long-term variation are investigated, which shows the shift of a favorable growing season to an earlier period of the year. The annual integral characteristic of the NDVI index was used, which characterizes the long-term changes in the vegetation index in the studied regions. A statistical analysis of the series of integral characteristics was carried out, the parameters of linear regression were determined. The behavior of these characteristics for the foothill and lowland regions of North Ossetia-Alania indicates the presence of long-term trends in the changing conditions of the growing season. For the southern regions of the Russian Federation, observational data show a relationship between trends in NDVI changes with a long-term improvement in climatic conditions for plant vegetation and changes in conditions during cold periods of the year. This factor should be taken into account in economic activities in the southern regions of the Russian Federation.
ACTIVE DYNAMICS OF TECHNOGENIC LANDSLIDE ON THE LEFT BOARD OF THE KHANIKOMDON RIVER (NORTH OSSETIA)
Authors:   Geophysical Institute – the Branch of Vladikavkaz Scientific Center of the Russian Academy of Sciences, CHOTCHAEV Khijsa , GANAPATHY Ganapathy ,   Vellore Institute of Technology, MELKOV Dmitry ,   Geophysical Institute – the Branch of Vladikavkaz Scientific Center of the Russian Academy of Sciences
Published: March 2021

The article is devoted to the technogenic triggering of the hazardous dynamic development of the landslide massif, which poses a threat of blocking the Khanikomdon stream with partial restrictions in the movement of residents of the mountain village of Dzuarikau. One of the main reasons for the intensive development of landslides in the Northern and Southern Jurassic shale depressions is the technogenic undercutting of slopes, caused mainly by the need of development of the mining industry or transport communications, although scientifically grounded pre-design solutions for minimizing the development of landslide processes can significantly reduce negative geoecological loads on the territory, which is especially important for the sustainable development of the mountainous areas. The aim of the work was to study the state of the landslide with modern measuring systems. Geophysical surveys were carried out by methods of vertical electrical and location-based sounding; the measurements of landslide movement were also carried out in the monitoring mode using surveys with a total station and a global positioning system GPS/GLONASS. The obtained results characterize a three-layer section of the “K” type with the thickness of a landslide high-resistivity massif of 18-21 m of crushed-loamy and gravelly composition, which is overlaid and underlain by more conductive clay strata. Geodetic observations show that the landslide body has moved throughout the entire monitoring period, but the velocities varied depending on the season. It is assumed that the seasonal variability in velocities is caused by the groundwater levels and associated pore pressures, which decrease when surface water is absent or cannot penetrate frozen landslide material, and increase when surface water from melting snow or rain penetrates the unfrozen landslide material.
DEVELOPMENT OF METHODS AND MANAGEMENT TOOLS AEROGASDYNAMICS PROCESSES AT MINING SITES
Authors:   North Caucasian Institute of Mining and Metallurgy (State Technological University), BOSIKOV Igor , KLYUEV Roman ,   Moscow Polytechnic University, KHETAGUROV Valery ,   North Caucasian Institute of Mining and Metallurgy (State Technological University), AZHMUKHAMEDOV Iskandar ,   Astrakhan State University
Published: March 2021

The practical development of the algorithm for optimal control of mine ventilation was preceded by comprehensive studies of the specific features of mining sites in order to obtain their mathematical description. The latter includes the static and dynamic characteristics of objects, i.e. the relationship between input and output values. The purpose of the research: to develop methods and management tools aerogasdynamics processes on mining sites of coalmines. Research methods. The methodology based on the system approach; modern methods of mathematical statistics, decision theory; mathematical logic devices; factor analysis; mathematical modeling; set theory and system analysis. To determine the dynamic characteristics of aerogasodynamic processes, experimental methods were used, divided into active and passive. The active method consists in con-structing a dynamic model of airing objects by approximating the transition curve obtained because of special effects on the airing object with an analytical expression. Statistical dynamics methods were used to obtain dynamic characteristics based on normal operation data. The method of correlation analysis was used. Results of research: experimental verification showed that the maximum relative error of in determining the methane concentration from the static characteristic constructed using a modified technique does not exceed 10 %. The value of the error was determined by comparing the static characteristic obtained by the modified correlation analysis method with the exact static characteristic of the airing object. The latter were found with regard to dynamic properties of the object and additive structures aerogas dynamics processes. Conclusion. The method of correlation analysis can be used to determine the dependence of the methane flow rate on the airflow rate in the steady-state mode, i.e. the static characteristic q = f (Q) for the site and lava. To determine the static characteristics based on the data of normal operation with a limited observation interval (5-10 days), a modified method of correlation analysis is proposed. Small values of the relative error of indicate the possibility and feasibility of using a modified correlation analysis technique to construct a static characteristic of the airing object based on random processes of methane concentration and air flow obtained during normal operation of the site. The static characteristics C= f (Q) and q= f(Q) are widely used to determine the mathematical expectations of the methane concentration and flow rate of mining sites, in the modeling of ventilation facilities and in the analysis and synthesis of mine ventilation control systems.
APPLICATION OF THE JET SCHEME AND FLOTATION MODE WITH A VAPOR-AIR MIXTURE DURING GOLD-BEARING ORES ENRICHMENT
Authors:   North Caucasian Institute of Mining and Metallurgy (State Technological University), EVDOKIMOV Sergey , GERASIMENKO Tatyana ,   North Caucasian Institute of Mining and Metallurgy (State Technological University), MARZOEV Azamat ,   North Caucasian Institute of Mining and Metallurgy (State Technological University)
Published: March 2021

Increasing the economic efficiency of enrichment of refractory gold-bearing ores is possible by reducing the cost of opening sulphide gold-bearing concentrates by reducing the yield of flotation concentrate sent to pyro- or hydrometallurgical processing. It is important to maintain the achieved level of gold recovery into concentrate with a lower concentrate yield. In order to achieve this goal, the gold content in the main flotation operation is increased by mixing the rough concentrate separated from ½ part of the ore feed with another ½ part of it. Mixing in the flotation operation of products with a high level of wash ability (ability to separate) – initial feed and rough concentrate – is identical to an increase in the content of the extractable component in the original ore. In accordance with the new regime of flotation, the process is carried out in cold slurry with bubbles filled with hot steam. The physical basis of the new flotation regime is the dependence of the surface properties of air bubbles and surface forces that determine the stability of the liquid film separating the bubble and the particle on the temperature, which increases due to the heat of the vapor-liquid phase transition. Radial oscillations of the bubble surface as a result of pressure pulsations during condensation and vapor evaporation and surface thermal flows of liquid in the wetting film are factors that provide an increase in the completeness of gold recovery and the selectivity of flotation adhesion obtained in ore flotation experiments. In laboratory conditions, a comparison was made of the indicators obtained during the dressing of gold-bearing ores according to the factory and new schemes. It was revealed that the use of the developed technology allows, with a lower concentrate yield, to obtain an increase of 7.06% abs. extraction of gold into a concentrate of the best quality. A decrease in gold losses with flotation tailings is a consequence of an increase in the number of particles reaching the bubble surface due to radial oscillations of its surface and a weakening of the stability of the wetting film by the thermo-capillary mechanism. An increase in adhesion selectivity can be interpreted using the concept of surface forces of structural origin – an increase in the forces of hydrophobic attraction and hydrophilic repulsion with increasing temperature. The interaction of vapor bubbles with nanobubbles on the surface of the solid phase (wetting by the Cassie-Baxter mechanism) ensures efficient particle recovery by the coalescence mechanism of flotation.
THE INFLUENCE OF THE CHARACTERISTICS VARIATIONS OF THE CONCENTRATING PLANT CONTROL OBJECT ON THE IDENTIFICATION RESULTS USING THE HAMMERSTEIN MODEL
Authors:   Volodymyr Dahl East Ukrainian National University, PORKUIAN Olga , MORKUN Vladimir ,   Kryvyi Rih National University, MORKUN Natalia ,   Kryvyi Rih National University, GAPONENKO Irina ,   Kryvyi Rih National University
Published: March 2021

As a result of the identification based on the Hammerstein model of objects of the first stage of iron ore magnetic separation, the adequacy of the model is obtained. All results of the testing of the developed identification algorithms show that the subsystem of identification of the automated process control systems of processing plants based on the Hammerstein hybrid model allows to carry out satisfactory identification of objects and, as a consequence, to improve the quality of technological processes. The study of the influence of the coefficient of various typical links on the results of identification using orthogonal parallel and parallel-recursive Hammerstein models showed that these models allow considering the differences in the properties of identifiable objects adequately.
Determining the Proper Mix of Incinerator Bottom Ash for Floor Tile Manufacturing
Authors: Lin Deng-Fong , Lin Kuo-Liang , Shieh Show-Ing , Chen Chia-Wen
Published: March 2021

Since 2003, researchers have attempted to reuse incinerator bottom ash (IBA), the residual from incinerating municipal solid waste, for ceramic production. This study focused on investigating proper IBA replacement level for manufacturing interior and exterior floor tiles. Firstly, raw materials of clay and IBA underwent SEM, EDS, and TCLP tests to determine their chemical contents. Six sets of specimens with different replacement levels of IBA (0%, 5%, 10%, 15%, 20%, and 30%) were then prepared. The specimens were calcined at 1000℃, 1050℃,1100℃, and 1150℃ and subsequently put through a series of mechanical tests to compare their performance. NMR (nuclear magnetic resonance spectroscopy) were also used to determining the organic compound structure after each specimens’ crystallization. Research results showed that proper mix of IBA up to 20% could result in quality tiles complying with specifications for interior and exterior flooring applications at certain kiln temperatures, while the specimens with 30% IBA failed to meet either bending strength or size shrinkage requirement at all kiln temperatures, and could not deliver a satisfactory result no matter what.
GhD14 regulates plant architecture and fiber development in cotton
Authors: Zhu Liping , Dou Lingling , Zhang Huizhi , Zhang Li , Liu Cuixia , Yu Jianing , Xiao Guanghui
Published: March 2021

Strigolactone (SL) signaling is essential in regulating plant development. DWARF14 (D14), the SL receptor, interacts with the F-box in MORE AXILLARY GROWTH (MAX2) to modulate SL signaling. However, the biological function of D14 protein is still unknown in cotton. Here, we identified GhD14s in Gossypium hirsutum and resolved its function in cotton plant architecture and fiber development. The GhD14D protein was localized to both the cytoplasm and nucleus. GUS staining assay showed that GhD14D was mainly expressed in leaf primordium, inflorescence, axillary bud and stem and expression analysis revealed that GhD14A/D was highly expressed in stem, flower and fiber cells at 20 days post-anthesis (DPA). Silencing GhD14A/D gene expression in upland cotton signiﬁcantly increased branch angle and reduced ﬁber length as well as the transcripts of secondary cell wall biosynthesis related genes. In addition, overexpression of GhD14D in Atd14 mutant successfully rescued the phenotype of the d14-1 mutant with much shoot-branching and short plant height. Our findings suggest that the GhD14 gene contributes to shoot branch development and fiber cell development in cotton. This study deepens our understanding of the biological role of SL signaling in cotton and providing guidance for modifying cotton plant architecture and improving fiber development using genetic engineering to help us breed better cotton varieties in the future.
Characterization of Municipal Solid Waste Incineration and Flue Gas Emission Under Anoxic Environment in Tibet Plateau
Authors: Zeng Dan , Zhou Wenwu , Zhou Peng , Che Yuechi , Han Zhiyong , Qiong A , Duo Bu , Lv Xuebin , Zhuoma Qiongda , Wang Jing , Yang Wang , Chen Guanyi
Published: March 2021

Waste incineration is a process of full combustion reaction between waste and oxygen at high temperature. It is a new problem whether the special natural environmental conditions of Tibet Plateau, such as low air pressure, low oxygen content and low temperature, will affect the waste incineration in the plateau area. In this work, the influence of different parameters on MSW incineration efficiency and flue gas emission were investigated. The results showed that the temperatures exhibited a significant impact on the flue gas emission. Under the lower temperature, CO was determined to be the main pollutant. With the increase of temperature, NOx became the main pollutant. The optimal temperature range of flue gas emission was between 800ºC to 900ºC. A slight negative pressure in incinerator was benefit for incineration system safety and flue gas emissions. The optimal range was -50Pa to 0Pa. Lower oxygen content (3%-6%) in the incinerator affected the incineration efficiency and flue gas emission. Meanwhile, the high oxygen content had no obvious impact on the flue gas emission, but the cost increased and the service life of the incinerator was affected. The optimal oxygen content in the incinerator was controlled at 6%-8%. Furthermore, the air temperatures, pressures and oxygen content in the natural environment had no significant effect on MSW incineration process. Increasing the air volume would bring about the increase of N 2 in the incinerator. This work provides the basic data support for MSW incineration technology in plateau area.
Evaluation of renal perfusion by Doppler ultrasonography and the effect of Ulinastatin to it in a porcine model of septic shock
Authors: Hang Chen-Chen , Guo Yu-Hong , Li Chun-Sheng , Wang Shuo
Published: March 2021

Objective

To develop a reliable and noninvasive method to evaluate the renal perfusion in a porcine model of septic shock and investigate the effect of UTI on it.

Methods

Thirty-two healthy male domestic pigs were randomly assigned to one of four groups: a sham group (SH, n=5); a septic shock group (SS, n=9); a septic shock group treated with vancomycin (15mg/kg) (VAN, n=9) and a septic shock group treated with UTI (50,000U/kg) + vancomycin (UTI, n= 9). Contrast-enhanced ultrasound (CEUS) of kidney at the baseline and the end of protocol (24h) were performed. The spectrum of interlobar or arcuate artery was selected to calculate the corrected resistive index (cRI). Sulphur hexafluoride (SF6) microbubbles were bolus injected via venous catheter. The peak intensity (Pi) and area under curve (AUC) were calculated by a time-intensity curve (TIC).

Results

cRI increased significantly at the end of the protocol except the SH groups, significant difference was found between each experimental group and the SH group. Linear regression was found between the cardiac output (CO) and Pi (Pi = 7.082 × CO + 5.026, R2=0.752, F=84.878, P < 0.001). The AUC decreased significantly post-injury in the SS and VAN group. All above parameters were improved by the UTI treatment, significant differences were found between the UTI and SS or VAN group respectively (P<0.05).

Conclusions

Septic shock occasionally accompanies with a significant low perfusion in renal microcirculation and UTI can improve it significantly.
Summarizing the Effects of Different Exercise Types in Chronic Low Back Pain – A Systematic Review of Systematic Reviews
Authors: Grooten Wilhelmus JA , Boström Carina , Dedering Åsa Stephansson , Halvorsen Marie , Kuster Roman P , Nilsson-Wikmar Lena , Olsson Christina B , Rovner Graciela , Tseli Elena , Rasmussen-Barr Eva
Published: March 2021

Background

Recently, a review of reviews concluded that exercise therapy of any type makes no difference to the effect on pain or disability in adult patients with acute low back pain (LBP). Whether this is also the case for exercise therapy in chronic LBP is still unknown.
Objectives

To summarize and synthesize systematic reviews (SR) and meta-analyses (MA) investigating the effects on pain and disability of common exercise types used in chronic LBP.
Methods

We included systematic reviews from several databases in which ≥ 75% of the studies were RCTs on adults between 18 and 70 years of age suffering from chronic or recurrent LBP for a period of at least 12 weeks. These were grouped into nine exercise types: Aerobic training, Aquatic exercises, Motor control exercises (MCE), Resistance training, Pilates, Sling exercises, Traditional Chinese Exercises (TCE), Walking, and Yoga. The study quality was assessed with AMSTAR-2. For each type of exercise, a narrative analysis was performed, and the levels of evidence for the effects of exercise were assessed through GRADE.
Results

The wide search resulted in 2,345 studies, and out of the 246 full texts that were screened, 41 SR/MA were included. Of these, 10 SR/MA were of high quality, 15 of moderate, 14 of low, and two of critically low quality. We found low to moderate evidence of mainly short-term and small beneficial effects on pain and disability for MCE, Resistance training, Pilates, TCE, and Yoga compared to no intervention. Few reviews were found for Aerobic, Aquatic, Sling, and Walking exercises, but with promising results. Aquatic exercises seem to be more beneficial compared to land exercises (low level of evidence).
Conclusions

In line with previous studies but in a broader perspective, this systematic review of reviews showed that there is low to moderate evidence that exercises are effective for reducing pain and disability compared to no or minimal interventions, but that no exercise type is more effective than other conservative interventions (very low to moderate evidence).
Systematic review registration number
PROSPERO: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=190409
Fisetin Exerts Anti-tumorigenic Activity via Inhibition of Trypsin Activity in Colorectal Cancer
Authors: Li Lin , Wang Min , Liu Zheng , Huang Xiaoling , Li Yuting , Guo Jialiang , Jiang Zhengjin
Published: March 2021

Background: Colorectal cancer (CRC) is a malignant tumor with high incidence and bad prognosis. Therapies, which are more safety and effective, are urgent needed in clinical. Trypsin is proved to be crucial to cancer proliferation and migration, therefore, it’s possible to control cancers through modulating the activity of trypsin. Fisetin is a flavone with excellent trypsin inhibition that screened from more than 45 compounds derived from traditional Chinese medicine. However, the effects and the mechanisms of fisetin on CRC have not been well investigated. Methods: In this study, we firstly evaluated the expression of trypsin on CRC cells. The effects of fisetin on proliferation and migration of CRC cells were also investigated in vitro. The inhibitory effects on cell cycle and apoptosis were assayed using flow cytometry. The therapeutic activity and toxicity were evaluated in vivo. Results: Fisetin remarkably inhibited CRC cell proliferation and migration, as well as induced cell apoptosis and Go/G1 phase arrest in a dose‐dependent manner. Mechanistic studies revealed these effects were mediated partially through signaling pathways involving cell cycle regulators p21, p27, cyclinD1 and NF kappa B (NF-κB) p65. Administration of fisetin also significantly suppressed the tumor growth in tumor-bearing NOG mice inoculated with human HCT116 cells. Fisetin at the given dosage did not induce significant acute or chronic toxicity in rats.Conclusions: Fisetin can inhibit the growth and migration of CRC by inhibiting the trypsin both in vitro and in vivo. Our results revealed fisetin is a potent therapy for CRC.
SELECTION OF OPTIMAL AL–SI COMBINATIONS IN CAST IRON FOR CASTINGS FOR ENGINEERING PURPOSES
Authors: Frolova Liliia , Shevchenko Roman , Shpyh Alona , Khoroshailo Vadim , Antonenko Yana
Published: March 2021

In this work, the optimal combinations of Al – Si in cast iron for cast parts for machine-building purposes were determined with the aim of subsequent selection of rational modes of modification and alloying, and the possibility of their implementation under industrial smelting conditions was checked.
The graphical dependence Si=f (Al) is obtained, which is a set of optimal combinations of the content of Al and Si in cast iron, providing the maximum ultimate tensile strength UTS≈245 ... 334 MPa.
The technological audit of the results of serial industrial smelting included the analysis of actual indicators, the calculation of sample distribution functions (mathematical expectation and dispersion) of the Al and Si content in the alloy, as well as the UTS value. The correspondence of the indicators of the content of Al and Si and the value of σ to the optimal values was assessed by testing the statistical hypotheses: H: M(Al)=Alopt, M(Si)=Siopt, M(σв)=σвopt.On the basis of the obtained results of the assessment of statistical characteristics and verification of hypotheses, it was established that at the chosen significance level α=0.05, the technological process of smelting satisfies the requirements of optimality in terms of the Si content, but in terms of the Al content, the technological process does not meet the requirements of optimality.
The proposed procedure for choosing the optimal combinations of Al and Si makes it possible to choose the amount of correcting additives depending on the actual indicators of the chemical composition during the smelting process. To do this, it is necessary to assess the closeness of the actual composition to the optimal curve Si=f(Al) and choose the one that most satisfies the criteria of rationality. The latter can be the cost of ferroalloys, through which Al and Si are introduced
ESTRATÉGIAS DEFENSIVAS EMPREGADAS POR CHEFIAS INTERMEDIÁRIAS DE UM HOSPITAL PÚBLICO FEDERAL DE ENSINO
Authors: Almeida Simone
Published: March 2021

RESUMO

A pesquisa teve por objetivo  analisar as estratégias defensivas empregadas por chefias intermediárias de um hospital público federal de ensino, utilizou-se a Psicodinâmica do Trabalho. Realizou-se uma pesquisa descritiva, de método misto por meio de estudo de caso. Estratégias defensivas individuais identificadas: conhecimento da instituição e sentimento de pertencimento; redimensionar a relevância dos problemas; estudar, fazer o que precisa ser feito; convívio familiar e atividade física; individualismo; servidão voluntária. Estratégias defensivas coletivas: conversa; motivação, apoio e oração em equipe; feedback; planejamento. Avaliação moderada a crítica para efeito da organização do trabalho e risco de adoecimento. Vivências de prazer: liberdade com a chefia para negociar e orgulho pelo trabalho exercido. Fatores de sofrimento: esgotamento emocional, estresse, sobrecarga. Danos físicos: alteração do sono, dores de cabeça, costas e corpo. Conclui-se que é preciso pensar em formas de  minimizar os fatores de sofrimento uma vez que esses profissionais são o elo entre a direção as diversas categorias de trabalhadores e usuários.

PALAVRAS-CHAVE OU DESCRITORES: Trabalho. Chefias intermediárias. Estratégias defensivas.
PADRONIZAÇÃO DE MATERIAIS EM UM HOSPITAL UNIVERSITÁRIO: ATIVIDADES E PROCESSO
Authors: ASSIS IEDA ROMERO ALVES DA SILVA , Binotto Erlaine , Casarotto Eduardo Luis
Published: March 2021

O processo de padronização tem por finalidade reduzir custos e otimizar a aplicação de recursos. O objetivo foi analisar as atividades de padronização de material médico hospitalar do HUfocal e propor um fluxograma estrutural para padronização dos materiais. É uma pesquisa descritiva, documental com abordagem qualitativa e aplicada. Utilizou-se documentos institucionais e entrevistas com membros da comissão de padronização de material e medicamentos e gestão de materiais. Analisou-se o panorama da padronização de materiais e procedimentos realizados pela comissão de padronização de medicamentos; as compras e ações de padronização de materiais no HUfocal; percepção do processo de padronização dos envolvidos no processo de suprimento; padronização de materiais nos demais hospitais que possuem comissão de padronização. A proposta contribuiu nas atividades que visam à otimização da padronização e aquisição, bem como ao atendimento a Lei nº 8.666/1993. Também para demonstrar que a padronização em compras públicas pode cumprir de fato sua finalidade, gerar eficiência, além de poder ser vista e e reconhecida como procedimento rotineiro e dinâmico.
Connotations of Identities in William Kurelek’s Paintings: Typology and Critical Art Analysis
Authors:   Department of Theory and History of Art, Lviv National Academy of Arts, Lviv, Ukraine, Beregovska Khrystyna O. , Zhavoronkova Myroslava I. , Krotova Tetiana F. , Demianchuk Andrii L. , Tarasenko Andrii A.
Published: March 2021

Despite the high popularity of William Kurelek in Canadian society, relatively few interpretations of his works can be found at the scientific, art criticism level. Based on the analysis of William Kurelek’s artistic legacy a typological study was conducted identifying the Canadian artist’s thinking and personal position declared openly in his art. A study of the thematic content of his paintings led to the identification of the following categories: personal, religious and awareness of community membership. The article outlines the difference between the notion of national and ethnic identity, which the artist saw in the difference between national and ethnic identity an instrument to self-awareness through membership in a particular community as a result of common spiritual, religious and social convictions with shared modes of behavior, mores and traditions. As a result of the study, we derived a certain formula of identity in the works of William Kurelek, which the author understood as a set of ethnic, national, gender-based, and religious characteristics inherent in a person, demonstrating its identity as the appropriate group affiliation. We also conducted a typology of identities in his art: personal, religious, awareness of community membership, national and ethnic. We analyzed the issues of commonality and differences between national and ethnic identity, designating them as “ethnic calmness” and “ethnic stress”.
Quantum Leap beyond the Frontiers: ‘Currentism’ in Visual Arts Production in the Nsukka School
Authors:   Lecturer in the Department of Fine and Applied Arts, University of Nigeria, Nsukka., Okoro Martins N.
Published: March 2021

There exists no scholarly publication espousing on the driving force behind the restless aspirations of the Nsukka artists towards searching for and using commonplace materials that the potent environment provides for supports and media for studio art production. Following this, my intent is to discuss the Nsukka artists’ creative inclinations, bordering on styles, ideas, forms, materials and technique. Through hermeneutical analysis, I examine some useful insights in the formal and conceptual principles for which their recent and current artworks are foregrounded. Relying on historical, interpretative and analytical methods of data illumination, I engage some selected unusual artworks executed between 1999 and 2017 by some selected Nsukka artists to authenticate the fact that Nsukka artists have taken a quantum leap beyond the frontiers of the human consciousness and in so doing, have mastered their oeuvres, bringing about great ingenuity and some unprecedented innovations in the execution of breath-taking postmodernist artworks whose formal contents and thematic probing interrogate germane issues.