bluuebunny/crossref_metadata_2025 huggingface dataset:
Navigating Legal and Regulatory Frameworks to Achieve the Resilience and Sustainability of Indigenous Socioecological Systems
Authors: Sakapaji Stephen Chitengi , García Molinos Jorge , Parilova Varvara , Gavrilyeva Tuyara , Yakovleva Natalia
Published: April 2024

The sustainability of Indigenous Socioecological Systems (ISES) largely depends on well-crafted policy regulations. In particular, Indigenous traditional food systems (ITFS) are an essential component of ISES that provide a variety of culturally accepted, healthy foods while also playing an important role in cultural, spiritual, and economic value to the Indigenous people (IP). Thus, sustainably managing these traditional natural resources must be a priority. As custodians of much of the world’s ecological system, IP have, for generations, exhibited sustainable lifestyles in governing these systems. However, Indigenous perspectives and voices have not been properly reflected in the ISES sustainability discourse, and few comparative case studies have addressed this issue. This study contributes to fill this research gap using a desktop research method based on the Political Ecological Theoretical Framework (PETF) to examine how existing regulatory policies may affect the resilience and sustainability of ISES-ITFS, especially in relation to growing environmental and climatic pressures. Two Indigenous communities, the Karen in Thailand and different Indigenous groups in the Republic of Sakha (Yakutia) in Russia, are examined as case studies. Our study provides crucial insight that should help the development of robust policy interventions that integrate Indigenous concerns into policies and regulations, emphasizing self-determination, cultural preservation, and land rights. The findings emphasize the necessity for comprehensive legal frameworks prioritizing Indigenous involvement and concerns in climate and sustainability policy implementations. The ultimate goal is to foster meaningful dialogues between policymakers and IP in navigating the climate and sustainability challenges of our time.
A Robust and Reliable UPLC Method for the Simultaneous Quantification of Rosuvastatin Calcium, Glibenclamide, and Candesartan Cilexetil
Authors: Ibrahim Mohamed Abbas , Sherif Abdelrahman Y. , Alshora Doaa , Alsaadi Badr
Published: April 2024

Metabolic syndrome is an associated condition that occurs together and increases the risk of heart disease and diabetes. These conditions include high blood pressure, high blood sugar, and high body mass index (BMI) in terms of cholesterol and triglyceride levels. Most of the elderly population may administer three drugs to control the above conditions. Therefore, this study aims to develop an analytical assay for the precise analysis of three components and to formulate a Self-Nanoemulsifying Drug-Delivery System (SNEDDS) loaded with three drugs: Rosuvastatin Calcium (RC; antilipidemic), Glibenclamide (GB; antidiabetic), and Candesartan Cilexetil (CC; antihypertensive). A design of the experiment was developed at a level of 32, and the influence of column temperature and flow rate was studied in terms of retention time, peak area, peak asymmetry, and resolution. The assay was subjected to several studies to ensure its validation. Under the optimized conditions—column temperature at 50 °C and flow rate at 0.25 mL/min—the three drugs, RC, GB, and CC, are separated. Their retention times are 0.840, 1.800, and 5.803 min, respectively. The assay was valid in terms of linearity, accuracy, and precision. Moreover, the developed assay shows a good tolerance against any change in the condition. The assay was tested also to separate the drugs in a pharmaceutical formulation as SNEDDs. The assay successfully separates the drug with a good resolution.
Isolation and Identification of Bitter Compounds in Ginseng (Panax ginseng C. A. Mey.) Based on Preparative High Performance Liquid Chromatography, UPLC-Q-TOF/MS and Electronic Tongue
Authors: Chen Yang , Liao Ziwei , Wang Zhe , Shi Wanyin , Xu Jian
Published: April 2024

As a traditional Chinese medicinal herb, ginseng (Panax ginseng C. A. Mey.) is commonly used to treat common diseases, for example, esophageal cancer and myasthenia gravis. Furthermore, ginseng is also processed into a functional food additive that is utilized to improve the freshness of chicken soup and make health wine. Unfortunately, ginseng (Panax ginseng C. A. Mey.) has already shown a noticeable bitterness during its application process. In this research, the bitter substances in ginseng (Panax ginseng C. A. Mey.) after two common preparation processes (water extraction and ethanol extraction) were separated, purified and identified by preparative high performance liquid chromatography (prep-HPLC), high performance liquid chromatography with diode array detector (HPLC-DAD), ultra-performance liquid chromatography coupled with high-resolution quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) and an electronic tongue. The results indicated that compared with the other four bitter compounds, the ginsenoside Rb1 had the highest bitterness value, followed by 20(S)-ginsenoside Rg2, ginsenoside Rg1, ginsenoside Rf and ginsenoside Rb3. Upon the evaluation of results to reduce the bitterness of ginseng extract, we found that the composite embedding system of chitosan adsorption in the ginseng carrageenan gel microsphere (K/MC/MCG) could effectively reduce the bitterness.
Spatiotemporal Patterns in the Urban Heat Island Effect of Several Contemporary and Historical Chinese “Stove Cities”
Authors: Huang Mengyu , Zhong Shaobo , Mei Xin , He Jin
Published: April 2024

Various cities in China have been identified as “stove cities” either in contemporary or historical times, exposing residents to extremely high temperatures. Existing studies on the heat island effect in stove cities are not representative nationwide. The outdated nature of these studies also significantly diminishes the relevance of their findings. Thus, reassessing the urban heat island (UHI) effect of stove cities is necessary in the context of global climate change and urbanization. This study focuses on seven symbolic and geographically distributed stove cities in China, including Nanjing, Chongqing, Wuhan, Fuzhou, Beijing, Xi’an, and Turpan. Using land surface temperature (LST) data, this study investigates the summer heat island effect from 2013 to 2023 and analyzes changes in the spatial distribution of the heat island effect. This paper utilizes impervious surface data and urban clustering algorithms to define urban and suburban areas. It then examines the evolution and spatial distribution of surface urban heat island intensity (SUHII) over time. Incorporating urbanization variables like population density and urban area, the study analyzes the main factors affecting the heat island effect from 2013 to 2018. We find that all cities continuously expand, with the annual average heat island effect intensifying over the years. With the exception of Beijing, the summer heat island or cool island effects in the remaining six cities show an overall intensification trend. From 2013 to 2018, SUHII has been primarily related to urban expansion and planning layout, with minimal impact from factors such as population density.
Comment on Lu et al. Ultrathin Terahertz Dual-Band Perfect Metamaterial Absorber Using Asymmetric Double-Split Rings Resonator. Symmetry 2018, 10, 293
Authors: Ullah Tariq , Rashid Aamir
Published: April 2024

In this study, the design of a dual-band terahertz absorber, previously published by Lu et al. (Symmetry 2018, 10, 293), was re-simulated. Our findings showed significantly different absorption results from those published in the article. A detailed analysis was conducted to explain this discrepancy, which was attributed to the reflection of an unaccounted orthogonal component of the waves from the design, rather than absorption. The metasurface design has two resonances at 4.48 THz and 4.76 THz, respectively. It was reported that at these frequencies, the structure achieved absorption of 98.6% and 98.5%, respectively. However, in our results, it was found that at the second resonance (4.76 THz), the structure acted as a strong cross-polarization converter, reflecting a significant amount of incident energy in the cross-polarization component of the reflected wave. When this component is considered in the reflection coefficient calculations, the absorption reduces to 41% (from 98.5%), which is not an acceptable level for an absorber. In addition, the structure was simulated for both lossy and lossless (FR4) substrate cases to understand the effect of substrate losses. The results showed that the absorption response significantly deteriorates at the first resonance (4.48 THz) in the case of a lossy FR4 substrate.
Risk Assessment and Countermeasures of Logistics Terminal Distribution under Public Health Emergencies
Authors: Bi Hualing , Zheng Ran , Lu Fuqiang
Published: April 2024

In recent years, the frequent occurrence of public health emergencies has affected people’s daily lives. In response, this paper evaluates the risk of logistics terminal distribution and puts forward the corresponding countermeasures. Firstly, this paper summarizes relevant literature and analyzes the characteristics of public health emergencies and logistics terminal distribution. This paper constructs the risk index system of logistics terminal distribution under public health emergencies for the first time. Secondly, this paper conducts a questionnaire survey on a domestic e-commerce enterprise. In this paper, the intuitionistic fuzzy entropy weight method is applied to the obtained data to determine the weight of risk index. Finally, this paper adopts the grey fuzzy comprehensive evaluation method to evaluate the risk index of logistics terminal distribution under public health emergencies. This paper takes the impact of public health emergencies into account for the risk of logistics terminal distribution for the first time. Some suggestions are provided for preventing the logistics terminal distribution from stagnation and paralysis when public health emergencies occur. This paper supplements the existing research in this field.
Developmental Toxicity of Fine Particulate Matter: Multifaceted Exploration from Epidemiological and Laboratory Perspectives
Authors: Yan Ruifeng , Ma Danni , Liu Yutong , Wang Rui , Fan Lifan , Yan Qiqi , Chen Chen , Wang Wenhao , Ren Zhihua , Ku Tingting , Ning Xia , Sang Nan
Published: April 2024

Particulate matter of size ≤ 2.5 μm (PM2.5) is a critical environmental threat that considerably contributes to the global disease burden. However, accompanied by the rapid research progress in this field, the existing research on developmental toxicity is still constrained by limited data sources, varying quality, and insufficient in-depth mechanistic analysis. This review includes the currently available epidemiological and laboratory evidence and comprehensively characterizes the adverse effects of PM2.5 on developing individuals in different regions and various pollution sources. In addition, this review explores the effect of PM2.5 exposure to individuals of different ethnicities, genders, and socioeconomic levels on adverse birth outcomes and cardiopulmonary and neurological development. Furthermore, the molecular mechanisms involved in the adverse health effects of PM2.5 primarily encompass transcriptional and translational regulation, oxidative stress, inflammatory response, and epigenetic modulation. The primary findings and novel perspectives regarding the association between public health and PM2.5 were examined, highlighting the need for future studies to explore its sources, composition, and sex-specific effects. Additionally, further research is required to delve deeper into the more intricate underlying mechanisms to effectively prevent or mitigate the harmful effects of air pollution on human health.
Comprehensive assessment of dental implant procedures: a comparative study on different antibiotic prophylaxis regimens
Authors: Gabidullina V. R. , Tsitsiashvili A. M. , Volkov A. V. , Stankova N. V. , Zaborovsky A. V. , Tsarev V. N. , Panin A. M. , Podporina V. V.
Published: April 2024

Relevance. The administration of antibiotics in implantology is indicated to prevent suppurative inflammation conditions. Two regimens are commonly used: a single preoperative dose or prolonged postoperative antibiotic administration. Due to ethical constraints, certain parameters of antibiotic efficacy cannot be directly evaluated within clinical trials. These include the status of the implant-mandibular segment microbiome and the histological parameters of the tissue's inflammatory response at the implant site.

Materials and methods. This study employed a miniature pig model comprising 10 males. The cohort was equally divided into two groups of five animals each. Group 1 received a single preoperative dose of amoxicillin/clavulanic acid 2 ml per 20 kg body weight. Group 2 received the same initial dose prior to implantation, followed by a daily postoperative dose of amoxicillin/clavulanic acid at 1 ml per 20 kg body weight for five days. Each animal received six dental implants. An implant site microbiological test was performed pre-surgery, on Day 1, 3, 7 and 14 post-surgery. Core needle biopsies for histological examination of the tissues were performed on the same postoperative days.

Results. Microbiological testing revealed that Group 2 exhibited lower levels of Streptococcus spp. on Day 3 (p = 0.04) and Porphyromonas spp. on Day 7 (p = 0.04). Group 1 demonstrated reduced levels of Fusobacterium spp. on Day 1 (p = 0.02) and Porphyromonas spp. both pre-surgery (p = 0.04) and on Day 1 (p = 0.012). Comparative analysis of histological assays from the implant sites indicated identical tissue inflammatory responses, regardless of the antibiotic prophylaxis regimen.

Conclusion. Both the single-dose and the prolonged antibiotic prophylaxis regimens, using amoxicillin/clavulanic acid for dental implantation, demonstrated similar histological patterns of tissue inflammation at the implant site, along with comparable microbiota profiles within the implant site. The oral mucosa exhibited an increased population of Staphylococcus spp. and Streptococcus spp., which might contribute to the development of resistant strains, as well as Candida spp., potentially increasing the risk of candidiasis infection onset.
ASSESSMENT OF RATOONING POTENTIAL IN VARIOUS PROMISING STRAINS OF SUGARCANE UNDER SOUTH PUNJAB CONDITIONS
Authors: Rauf Hafiz Abdul , Masood Syed Ahtisham , Khaliq Abdul , Hussain Fida , Qadir Tauqeer , Ahmad Idrees , Ullah Hafiz Muhammad Zia , Saleem Saira , Ali Barkat , Khan Aftab Ahmad , Umair Adnan , Mehmood Umair
Published: April 2024

The present study aimed to assess the ratooning potential of various sugarcane strains at the Sugarcane Research Station Khanpur during the 2019-20 period. The selected promising sugarcane genotypes, including S2013-US-917, S2014-SL-1359, S2014-SL-2200, PSR-07-45, S2015-SL-89, S2015-SL-289, S2015-SL-404, S2015-SL-444, CPF-253, and HSF-240 (check), were subjected to experimentation. The research followed a Randomized Complete Block Design (RCBD) with three replications. Significant variations in ratooning performance were observed among the studied genotypes. Notably, the strain S2015-SL-444 emerged as the most promising, exhibiting the highest cane yield at 119.80 tons per hectare and excellent stubble sprouting with 1.64 sprouts per plant. Additionally, this top-performing strain demonstrated good quality, registering a field brix of 19.55%. Although the highest field brix (21.65%) was recorded in S2013-US-917, S2015-SL-89 closely followed with a field brix of 21.24%. S2015-SL-444, the standout sugarcane clone, outperformed the check by producing 14.02 tons more ratoon cane yield per hectare. Therefore, it is recommended that the genotype S2015-SL-444, with its exceptional ratooning potential, be cultivated in the agro-ecological climatic conditions of South Punjab for ratoon crop cultivation
COMPARATIVE EFFECTS OF VARIETIES AND ROOTSTOCK AGE ON SUCCESS AND SURVIVAL RATE OF EPICOTYL GRAFTING IN MANGO (MANGIFERA INDICA L.)
Authors: jamali Muzamil Farooque , Memon Noor-un-Nisa , Wahocho Niaz Ahmed , Jamali Fayaz Ali , Ahmad Waqas , Talpur Afifa , Jamali Ali Raza , Magsi Hub e Ali , Ali Asghar
Published: April 2024

Epicotyl grafting is considered as the most efficient grafting technique in mango (Mangifera indica L.) and it is also well documented for timely seedling production of desired varieties. Therefore, the present study was perceived to assess the success and survival rate of epicotyl grafting. The study was conducted using a container-based setup and involved two factors: three varieties (Langra, Sindhri, and Chaunsa) and four different rootstock ages (20, 30, 40, and 50 days). The experiment was carried out in Completely Randomized Design (CRD) with 36 treatment combinations distributed equally in three replications. The findings revealed that all the studied traits were significantly affected by varieties and rootstock ages. It was further noted that Chaunsa variety showed best results for most of the studied traits except days to bud break and first flush while 50 days old rootstock demonstrated satisfying results for most of the parameters followed by 40 days old rootstock while the lowest results for all the traits were found in 20 days old rootstock except days to bud break and first flush. It is concluded that well established rootstock of 50 days and Chaunsa variety were found best for epicotyl grafting in mango
Kirigami-Triggered Spoof Plasmonic Interconnects for Radiofrequency Elastronics
Authors: Yao Xincheng , Li Min , He Shuchang , Jing Liqiao , Li Chenming , Tao Jie , Hui Xiaonan , Gao Fei , Song Jizhou , Chen Hongsheng , Wang Zuojia
Published: April 2024

The flexible and conformal interconnects for electronic systems as a potential signal transmission device have great prospects in body-worn or wearable applications. High-efficiency wave propagation and conformal structure deformation around human body at radio communication are still confronted with huge challenges due to the lack of methods to control the wave propagation and achieve the deformable structure simultaneously. Here, inspired by the kirigami technology, a new paradigm to construct spoof plasmonic interconnects (SPIs) that support radiofrequency (RF) surface plasmonic transmission is proposed, together with high elasticity, strong robustness, and multifunction performance. Leveraging the strong field-confinement characteristic of spoof surface plasmons polaritons, the Type-I SPI opens its high-efficiency transmission band after stretching from a simply connected metallic surface. Meanwhile, the broadband transmission of the kirigami-based SPI exhibits strong robustness and excellent stability undergoing complex deformations, i.e., bending, twisting, and stretching. In addition, the prepared Type-II SPI consisting of 2 different subunit cells can achieve band-stop transmission characteristics, with its center frequency dynamically tunable by stretching the buckled structure. Experimental measurements verify the on-off switching performance in kirigami interconnects triggered by stretching. Overcoming the mechanical limitation of rigid structure with kirigami technology, the designer SPIs exhibit high stretchability through out-of-plane structure deformation. Such kirigami-based interconnects can improve the elastic functionality of wearable RF electronics and offer high compatibility to large body motion in future body network systems.
Epidemiology and Prevalence of Dyslipidemia Among Adult Population of Tehran: The Tehran Cohort Study
Authors: Shafiee Akbar , Kazemian Sina , Jalali Arash , Alaeddini Farshid , Saadat Soheil , Masoudkabir Farzad , Tavolinejad Hamed , Vasheghani-Farahani Ali , Arita Vicente Artola , Sadeghian Saeed , Boroumand Mohamamdali , Karimi Abbasali , Franco Oscar H
Published: April 2024

Background: Dyslipidemia is among the leading risk factors for cardiovascular diseases (CVDs), with an increasing global burden, especially in developing countries. We investigated the prevalence of dyslipidemia and abnormal lipid profiles in Tehran. Methods: We used data from 8072 individuals aged≥35 from the Tehran Cohort Study (TeCS) recruitment phase. Fasting serum total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and triglyceride were measured. Dyslipidemia was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria, and high LDL/HDL was defined as a ratio>2.5. The age-sex standardized prevalence rates were calculated based on the 2016 national census. Furthermore, the geographical distribution of dyslipidemia and lipid abnormalities was investigated across Tehran’s zip code districts. Results: The age-sex standardized prevalence was 82.7% (95% CI: 80.1%, 85.0%) for dyslipidemia, 36.9% (95% CI: 33.8%, 40.1%) for hypertriglyceridemia, 22.5% (95% CI: 19.9%, 25.4%) for hypercholesterolemia, 29.0% (95% CI: 26.1%, 32.1%) for high LDL-C, 55.9% (95% CI: 52.6%, 59.2%) for low HDL-C, and 54.1% (95% CI: 50.9%, 57.3%) for high LDL/HDL ratio in the Tehran adult population. The prevalence of dyslipidemia, low HDL-C, and high LDL/HDL ratio was higher in the northern regions, hypercholesterolemia was higher in the southern half, and high LDL-C was more prevalent in the middle-northern and southern areas of Tehran. Conclusion: We found a high prevalence of dyslipidemia, mainly high LDL/HDL in the Tehran adult population. This dyslipidemia profiling provides important information for public health policy to improve preventive interventions and reduce dyslipidemiarelated morbidity and mortality in the future.
Gut-Lung Microbiota Characterization in Patients with Non-Small Cell Lung Carcinoma and COVID-19 Coinfection
Authors: Vakili Bahareh , Shoaei Parisa , Shahzamani Kiana , Siadat Seyed Davar , Shojaei Hasan , Esfandiari Zahra , Nasri Elahe , Shabani Shiva , Zamani Moghadam Ali , Ataei Behrooz
Published: April 2024

Background: Non-small cell lung cancer (NSCLC) patients with COVID-19 have an excessive chance of morbidity and mortality. The fecal-nasopharyngeal microbiota compositions of NSCLC patients were assessed in this study. Methods: In total, 234 samples were collected from 17 NSCLC patients infected with COVID-19, 20 NSCLC patients without confirmed COVID-19, 40 non NSCLC patients with COVID-19, and 40 healthy individuals. Results: In lung microbiota, the abundance of Streptococcus spp. in NSCLC patients with confirmed COVID-19 was significantly higher than the two control groups. Pseudomonas aeruginosa and Staphylococcus aureus were listed as the most frequent pulmonary bacterial groups that colonized COVID-19 patients. In fecal specimens, the numbers of Bacteroidetes, Firmicutes, and Actinobacteria phyla were significantly higher amongst NSCLC patients with COVID-19. NSCLC patients infected with COVID-19 showed lower levels of Lactobacillus spp., Akkermansia muciniphila, and Bifidobacterium spp. The counts of Streptococcus spp., in NSCLC patients with COVID-19 were significantly higher than those of healthy individuals (8.49±0.70 log CFU/g wet feces vs 8.49±0.70 log CFU/g wet feces). Prevotella spp. were enriched in the gut and respiratory tracts of COVID-19 patient groups. The unbiased analysis showed an increment in Enterococcus spp., Streptococcus spp., and Prevotella spp. Conclusion: Eventually, it was found that compared to control groups, COVID-19 patients with NSCLC showed diminished gut bacteria diversity and increase in Lactobacillus spp., A. muciniphila, and Bifidobacterium spp. The overgrowth of Enterococcus spp., Streptococcus spp., and Prevotella spp. could be potential predictive biomarkers in the gut-lung axis of NSCLC patients with COVID-19.
Genetic Analysis of 27 Y-STR Haplotypes in 11 Iranian Ethnic Groups
Authors: Alinaghi Somayeh , Mohseni Marzieh , Fattahi Zohreh , Beheshtian Maryam , Ghodratpour Fatemeh , Zare Ashrafi Farzane , Arzhangi Sanaz , Jalalvand Khadijeh , Najafipour Reza , Khorram Khorshid Hamid Reza , Kahrizi Kimia , Najmabadi Hossein
Published: April 2024

Background: The study of Y-chromosomal variations provides valuable insights into male susceptibility in certain diseases like cardiovascular disease (CVD). In this study, we analyzed paternal lineage in different Iranian ethnic groups, not only to identify developing medical etiology, but also to pave the way for gender-specific targeted strategies and personalized medicine in medical genetic research studies. Methods: The diversity of eleven Iranian ethnic groups was studied using 27 Y-chromosomal short tandem repeat (Y-STR) haplotypes from Y-filer® Plus kit. Analysis of molecular variance (AMOVA) based on pair-wise RST along with multidimensional scaling (MDS) calculation and Network phylogenic analysis was employed to quantify the differences between 503 unrelated individuals from each ethnicity. Results: Results from AMOVA calculation confirmed that Gilaks and Azeris showed the largest genetic distance (RST=0.35434); however, Sistanis and Lurs had the smallest considerable genetic distance (RST=0.00483) compared to other ethnicities. Although Azeris had a considerable distance from other ethnicities, they were still close to Turkmens. MDS analysis of ethnic groups gave the indication of lack of similarity between different ethnicities. Besides, network phylogenic analysis demonstrated insignificant clustering between samples. Conclusion: The AMOVA analysis results explain that the close distance of Azeris and Turkmens may be the effect of male-dominant expansions across Central Asia that contributed to historical and demographics of populations in the region. Insignificant differences in network analysis could be the consequence of high mutation events that happened in the Y-STR regions over the years. Considering the ethnic group affiliations in medical research, our results provided an understanding and characterization of Iranian male population for future medical and population genetics studies.
Impact of Implementing a Standard Operating Procedure to Reduce Blood Wastage in Blood Centers of Iran
Authors: Javadzadeh Shahshahani Hayedeh , Sharifi Shahin , Nasizadeh Soheila
Published: April 2024

Background: Blood wastage leads to additional costs and reduced blood availability to patients. Above all is the moral issue of wasting donor gifts. This study aimed to determine the rate of blood wastage before and after implementing a new standard operating procedure (SOP) in Iran. Methods: In this interventional study, a SOP for wastage management was prepared and implemented in all blood centers throughout the country. Data were extracted from the integrated software of the Iranian Blood Transfusion Organization (IBTO). The wastage rate of blood components in the post-intervention years (2016-2017) was then compared with that in the pre-intervention years (2013-2015) using the Z test. Results: The overall wastage rate decreased by 36.86% (P<0.001, 95% CI [36.84-36.88]) after the intervention. Red blood cell (RBC) wastage decreased from 2.6% to 2.5%, platelet wastage from 19.5% to 10.6% and plasma wastage from 15.5% to 7.3% (P<0.001). The highest percentage of waste reduction pertained to plasma components, which decreased by 52.90% (P<0.001, 95% CI [52.86-52.94]). Expiration was the most common cause of RBC and platelet wastage. The most common causes of plasma wastage were RBC contamination and rupture or leakage of the bags. The intervention resulted in a drop of over 250000 discarded components each year, equal to approximately thirty-six million dollars in savings. Conclusion: This intervention effectively reduced waste and increased efficiency. Ongoing blood wastage reviews, auditing, and receiving feedback from the central headquarters were powerful tools in following the compliance of blood centers. Further studies are recommended, especially concerning blood wastage in hospital blood banks and various wards.
In Commemoration of Dr. Mostafa Pourtaghva Shahrestani, a Pioneer in Infectious Disease Research
Authors: Bardestani Fatemeh , Rad Mohammad Ali , Azizi Mohammad Hossein , Gouya Mohammad Mehdi , Mostafavi Ehsan
Published: April 2024

It is important to honor the contributions of scientific leaders who have dedicated their lives to advancing knowledge and serving their country. One way is to document their experiences and personalities in a documentary format, which can serve as a historical record and an inspiration for future generations. Dr. Mostafa Pourtaghva Shahrestani, a renowned physician and specialist in infectious diseases and tropical medicine, has made significant contributions to public health in Iran. He has played a crucial role in controlling infectious diseases such as smallpox, tuberculosis, rabies, plague, and cholera. Throughout his career, he has held various executive positions, including the head of Pasteur Hospital and the director of the Pasteur Institute of Iran. Dr. Pourtaghva’s life is a testament to his unwavering dedication to public health services, as evidenced by his continuous effort, love, and interest in honest work. His inspiring story can serve as a model for those who seek to follow in his footsteps.
The Role of Inflammatory Indices in Predicting Infections and Guiding Treatment in Neutropenic Patients With Solid Tumors
Authors: Ebrahimzadeh Azadeh , Zare Bidaki Majid , Alemzadeh Effat , Izadpanahi Payam , Kazemi Behjat , Askari Parvin , Khosrojerdi Arezou , Sebzari Ahmad Reza
Published: April 2024

Introduction: This study explores the link between inflammatory markers and hospital outcomes in febrile neutropenic patients with solid cancers- a complication caused by systemic chemotherapy that can lead to hospitalization and requires timely diagnosis and treatment to reduce fatalities. Methods: This study was conducted in 2017 at Vali-e-Asr Hospital in Birjand with 22 participants. Blood samples were collected to measure inflammatory indexes. The study documented various hospital outcomes, including duration of neutropenia and fever correction, length of hospital stays, ICU admission or mechanical ventilation, and mortality. Accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for each marker. Results: According to the findings, there was no significant difference in the mean duration of neutropenia, the duration of fever, or the length of hospital stay comparing procalcitonin (PCT; P=0.96, P=0.36, P=0.66, respectively), polymorphonuclears (PMNs; P=0.11, P=0.94, P=0.52, respectively), and erythrocyte sedimentation rate (ESR; P=0.41, P=0.24, P=0.17, respectively). Further, the performance metrics calculated for PCT, ESR, and PMNs were an accuracy of 50%, 50%, and 40.90%, sensitivity of 88.8%, 100%, and 88.8%, specificity of 23.07%, 15.38%, and 7.6%, PPV of 44.4%, 45%, and 40%, and NPV of 75%, 100%, and 50%, respectively. Conclusion: Our findings suggested that there was no significant relationship between inflammatory factors and hospital outcomes. However, further research is needed to explore the prognostic value of these markers in a larger and more diverse patient population.
Frequency of dry eye syndrome in patients with multiple sclerosis: A cross-sectional case-control study
Authors: Sorkhabi Rana , Khavandi Siamak , Ayromlou Hormoz , Ahoor Mohammad Hosein , Mohammadkhani Mehdi , Tabibzadeh Elsa
Published: April 2024

Introduction: Demyelination of the nerve fibers of the central nervous system is a main pathology of multiple sclerosis (MS), in which inflammation plays a major role. Studies have shown that inflammation is the leading cause of dry eye disorder. To investigate the association between inflammation and both diseases, we aimed to estimate the prevalence of dry eye syndrome (DES) in MS patients and its correlation with the severity of the disease and disability status. Methods: We enrolled 100 MS patients randomly and 100 healthy controls. DES was evaluated by Dry Eye questionnaire and Scoring System (DESS), tear break-up time (TBUT), tear meniscus height (TMH), and Schirmer 1 & 2 tests in subjects. Furthermore, the leading disability in MS was assessed by a clinician (neurology professor) using the related questionnaire (Expanded Disability Status Scale). Results: According to the TBUT, THM, and Schirmer tests, the number of subjects with abnormal results was significantly higher in the MS group than in the control group. The severity of DES measured by the DESS was also higher in the MS group compared to control group. Also, there was a significant relationship between increasing disability and abnormal dry eye tests, especially in MS patients with EDSS scores>4. Conclusion: The present study highlights the importance of considering dry eye disorder in MS patients as a possible consequence of inflammation. Also, our results suggested a significant relationship between dry eye disorder and the EDSS scores.
ANALISIS JENIS-JENIS MANGROVE DI PULAU KAKABAN, KP. PAYUNG-PAYUNG, KECAMATAN MARATUA, KABUPATEN BERAU, KALIMANTAN TIMUR
Authors: Rani Rani , Sarmansyah Sarmansyah , Ridwan Iin
Published: April 2024

Mangrove memiliki signifikansi yang besar bagi kehidupan di daerah pesisir. Vegetasi ini memiliki peran yang penting dalam melindungi pantai dan menjaga keanekaragaman hayati melalui ekosistem mangrove. Tujuan dari penelitian ini adalah untuk memahami sebaran mangrove di Pulau Kakaban, Kepulauan Payung-Payung, Kecamatan Maratua, Kabupaten Berau, Kalimantan Timur. Penelitian ini dilakukan dengan menggunakan metode observasi dan teknik jelajah. Hasil penelitian menunjukkan adanya empat jenis mangrove yang dapat diamati di Danau Kakaban, yaitu Avicennia alba, Bruguiera gimnorrhiza, Ceriop decandra, dan Sonneratia alba. Analisis dilakukan melalui metode survei dengan teknik jelajah, di mana lokasi penelitian dijelajahi, sampel diambil, dan dokumentasi dilakukan. Lokasi ini merupakan daerah yang banyak dihuni oleh pohon mangrove dengan substrat berlumpur dan sedikit berpasir. Selain mempelajari vegetasi mangrove, penelitian ini juga melakukan pengukuran salinitas (kadar garam) dan pH (derajat keasaman) perairan di Pulau Kakaban. Nilai pH berada dalam rentang yang dapat ditoleransi oleh pertumbuhan mangrove, yaitu sekitar 5,0-8,0. Nilai pH air merupakan salah satu faktor yang mempengaruhi produktivitas perairan. Selain itu, salinitas perairan mencapai 32%, kondisi ini sangat mendukung pertumbuhan dan perkembangan mangrove. Komposisi substrat yang didominasi oleh lumpur juga memberikan nutrisi yang cukup bagi pertumbuhan optimal tanaman mangrove jika dibandingkan dengan komposisi substrat berpasir.Kata Kunci: Kabupaten Berau, Kepulauan Kakaban, Parameter, Vegetasi Mangrove.
PENGEMBANGAN MODUL BIOLOGI PADA MATERI VERTEBRATA KELAS X DI SMAN 3 PASURUAN
Authors: Qomariyah Jamilatul , Ardiansyah Reza
Published: April 2024

Penelitian ini bertujuan untuk mengetahui cara pengembangan produk dan kelayakan modul biologi pada materi verebrata kelas X di SMAN 3 Pasuruan. Modul biologi pada materi vertebrata dikembangkan menggunakan metode penelitian Research and Development dengan model pengembangan yang dikembangkan oleh Sugiyono. Hasil validasi ahli materi didapatkan bahwa produk yang dikembangkan memperoleh kategori layak dengan persentase kelayakan 75 %, ahli media memperoleh kategori layak dengan persentase kelayakan 73,71 %, penilaian guru biologi memperoleh kategori layak dengan persentase kelayakan 72,5% dan dari tanggapan peserta didik memperoleh persentase kelayakan sebesar 83,33% sehingga modul biologi pada materi vertebrata sangat layak digunakan sebagai sumber belajar dalam kegiatan pembelajaran. Penelitian ini hanya dilakukan dalam skala terbatas sehingga perlu dikembangkan ke lingkup yang lebih luas.
EFEK PEMBERIAN AIR REBUSAN DAUN SIRSAK (Annona muricata L.) TERHADAP HORMON KORTISOL PADA MENCIT YANG DIINDUKSI DEPRESI
Authors: Suhadia Maria Hyasinta Vanesa Putri , Luthfiyyah Sri , Tika Debek Bini Dita Rahayu Mayang , Amanu Aurelya Putri , Mentari Diani
Published: April 2024

Depresi dapat meningkatkan kadar kortisol hingga 20 kali. Daun sirsak (Annona muricata L.) memiliki banyak manfaat, salah satunya karena kandungan antioksidan yang terdapat di dalamnya. Penelitian ini bertujuan untuk melihat efektifitas penggunaan air rebusan daun sirsak sebagai anti depresi dengan melihat kadar kortisol pada mencit yang diinduksi depresi. Stressor dan air rebusan daun sirsak diberikan selama 7 hari. Pengukuran hormon kortisol menggunakan metode ELISA. Deteksi senyawa pada rebusan daun sirsak menggunakan metode Kromatografi Lapis Tipis (KLT) dengan pereaksi semprot FeCl3. Hasil analisis KLT menunjukkan bahwa pada air rebusan daun sirsak mengandung senyawa fenol. Hasil analisis hormon kortisol menunjukkan bahwa pemberian air rebusan daun sirsak mampu menghambat pembentukan kortisol pada mencit yang diinduksi stresor. Hal ini juga terlihat dari peningkatan berat badan mencit yang diberikan air rebusan daun sirsak mengalami kenaikan mencapai 15,48- 28,05% dibandingkan dengan kontrol negatif yang hanya meningkat 4,82%.
ANALISIS HASIL BELAJAR KOGNITIF MAHASISWA JURUSAN PENDIDIKAN BIOLOGI PADA MATA KULIAH GENETIKA DASAR
Authors: Retnaningati Dewi , Ibrahim Ibrahim , Ilma Silfia
Published: April 2024

Hasil belajar merupakan salah satu hal penting dari proses pembelajaran, sehingga untuk mencapai hasil belajar yang baik diperlukan kemampuan kognitif yang baik pula. Hal ini memberikan tantangan kepada pendidik untuk berinovasi dalam menentukan model/metode pembelajaran dan pemanfaatan media pembelajaran yang sesuai sehingga dapat membantu meningkatkan kemampuan kognitif peserta didik. Hasil belajar kognitif peserta didik perlu dievaluasi sehingga pada proses pembelajaran berikutnya dapat dikembangkan model/metode pembelajaran serta penggunaan media yang tepat. Penelitian ini bertujuan untuk menganalisis hasil belajar kognitif mahasiswa jurusan Pendidikan Biologi di Universitas Borneo Tarakan. Pendekatan penelitian yang digunakan adalah deskriptif kualitatif dan teknik pengumpulan data dilakukan dengan tes kognitif. Data nilai mahasiswa diperoleh dari hasil evaluasi materi pada mata kuliah Genetika Dasar. Hasil penelitian menunjukkan bahwa mahasiswa memiliki hasil belajar kognitif â€œsangat baikâ€ sebesar 16,67%, â€œbaikâ€ sebesar 50%, dan â€œcukupâ€ sebesar 33,33%.
KEANEKARAGAMAN JENIS RUSA Cervus sp. dan Axis sp. DI BUKIT WARUWANGI, KABUPATEN SERANG, BANTEN
Authors: Cahyani Adira , Utari Mulya , Ranisah Ranisah , Amalia Reza
Published: April 2024

Rusa merupakan hewan mamalia yang terdiri dari beberapa spesies. Spesies rusa yang ada di Indonesia misalnya rusa timor (Cervus timorensis), dan rusa totol (Axis axis). Setiap jenis rusa memiliki karakteristik atau ciri masing-masing. Penelitian ini bertujuan untuk mengetahui jenis rusa yang ada di Wisata Agro Bukit Waruwangi Kabupaten Serang. Sampel yang digunakan adalah 11 ekor rusa Timor dan 3 ekor rusa totol yang dipelihara pada dua penangkaran di bukit Waruwangi, Kabupaten serang. Metode yang digunakan adalah metode observasi yaitu denganÂ  mengamati warna rambut, bentuk tanduk, pakan, lingkungan penangkaran. Hasil penelitian menunjukkan adanya perbedaan antara rusa timor dan rusa totol. Secara morfologi rusa timor memiliki warna rambut kuning kecoklatan, sedangkan pada rusa timor memiliki warna coklat terang dengan corak putih ditubuhya. Selain itu, bentuk tanduk rusa totol keras, dan runcing dibagian ujung tanduknya atau disebut tanduk keras, dan pada rusa timor terdapat dua jenis tanduk rusa yaitu tanduk keras dan pedicle. Jenis pakan rusa totol dan rusa timor yaitu ranting muda dan dedaunan. Sistem pemeliharaan rusa timor dan rusa totol pada dua kawasan penangkaran di bukit Waruwangi Kabupaten Serang, merupakan penangkaran yang semi terkurung (mini ranch) di padang savana atau padang rumput yang terjaga sanitasinya.
INOVASI MEDIA PEMBELAJARAN BERBASIS ADOBE FLASH CS6 DAN BINSCAN PADA MATERI PERUBAHAN LINGKUNGAN
Authors: Gusti Utari Akhir , Azzahra Waliyyatu , Widodo Ari
Published: April 2024

Learning media has a strategic role in helping teachers in schools. Currently, the majority of teachers use media in the learning process. This has proven to be efficient in increasing students' interest in learning in class. A lot of research has been carried out to develop learning media. However, there are still few who analyze the innovation of original media with digital. So, research was conducted to analyze media-based learning innovationsAdobe flash Ac6 andBinscan on environmental change material. This research is classified as descriptive qualitative. The research aims to provide an overview of learning media innovation. Data collection techniques using observation, interview, and literature study. The results of the research are learning media innovations at the introductory, core and closing stages of learning. The application modified in this research is Adobe Flash. Meanwhile, applications designed to support learning, namelyBinscan. This innovation can be used as consideration for teachers to use in learning at school.
MENINGKATKAN HASIL BELAJAR SISWA DI ERA MERDEKA BELAJAR MELALUI MODEL DISCOVERY LEARNING: SEBUAH KAJIAN LITERATUR
Authors: Khasanah Uswatun , Siswandari Siswandari , Murwaningsih Tri
Published: April 2024

Penelitian ini bertujuan untuk menganalisis dan mengetahui apakah model discovery learning dapat meningkatkan hasil belajar siswa di era merdeka belajar. Jenis penelitian ini yaitu penelitian kualitatif dengan pendekatan kajian literatur. Teknik pengumpulan data dalam penelitian ini yaitu dengan mengumpulkan data melalui berbagai sumber artikel ilmiah yang relevan dengan topik penelitian. Data yang telah terkumpul kemudian dianalisis lebih mendalam dan disajikan dalam tulisan ilmiah. Pencarian data jurnal dalam penelitian ini menggunakan data base Google Scholar dengan rentang waktu tahun 2022. Berdasarkan pencarian jurnal yang telah dilakukan, ditemukan 15 jurnal yang relevan. Hasil dari penelitian ini mengungkapkan bahwa model discovery learning merupakan salah satu model yang dapat meningkatkan hasil belajar siswa di era merdeka belajar.
EFEKTIVITAS MEDIA PEMBELAJARAN QUIPPER SCHOOL TERHADAP HASIL BELAJAR SISWA PADA MATA PELAJARAN IPA DI SMP NEGERI 4 TARAKAN
Authors: Dayu Exnoni Sri , Wijarini Fitri , Ibrahim Ibrahim
Published: April 2024

Penelitian ini merupakan penelitian pre-experimental design yaitu experiment semu yang bertujuan untuk mengetahui efektivitas media pembelajaran Quipper School terhadap hasil belajar siswa pada mata pelajaran IPA Serta Respon Siswa Terkait penggunaan Media pembelajaran Quipper School di SMPN 4 Tarakan. Desain penelitian yang digunakan adalah One Grorup Pretest-Posttest Design. Penelitian ini dilaksanakan di SPMN 4 Tarakan. Populasi dalam penelitian ini adalah peserta didik kelas VIII SMPN 4 Tarakan, dengan jumlah sampel 30 siswa yang dipilih dengan menggunakan teknik Cluster random sampling. Instrument penelitian ini yaitu soal tes hasil belajar sistem pernapasan dan angket respon siswa dengan skala likert. Teknik analisis data hasil belajar yang digunakan yaitu analisis statistik inferansial parametris menggunakan paired sample t-test. Berdasarkan analisis statistik inferensial menggunakan SPSS diperoleh nilai signifikan 0.000 0.05 yang berarti Ha diterima, yakni penggunaan media pembelajaran Quipper School efektif terhadap hasil belajar siswa pada mata pelajaran IPA di SMPN 4 Tarakan. Berdasarkan analisis angket respon siswa diperoleh nilai rata-rata persentase yaitu 80,29% yang berarti siswa memiliki respon positif terkait penggunaan media pembelajaran Quipper School.
A pozitív idősödés magyar diskurzusairól
Authors: Tóth Dalma
Published: April 2024

A recenzió alapjául szolgáló mű bibliográfiája: Bene Ágnes és Móré Marianna (2024): Pozitív idősödés 1., Debreceni Egyetemi Kiadó, Debrecen. ISBN 978-963-615-006-8
A felhő alapú oktatás miértjei, kérdései, kihasználatlan lehetőségei
Authors: Katona Lászlóné , Katona Kitti , Mező Katalin
Published: April 2024

Jelen tanulmány azzal a céllal készült, hogy bemutasson egy hétköznapi, az oktatásban jól alkalmazható digitalizált oktatási eljárást, mely a felhő alapú rendszerek felhasználásán alapszik. A tanulmány célja, egy, a matematika tanításában már bevált módszer bemutatása, mely tantárgytól függetlenül is eredményesen használható. A tanulmány rávilágít azokra a mindenki számára elérhető opciókra, digitalizálási lehetőségekre, melyek a hétköznapi oktatásban, a köznevelés minden területén eredményesen alkalmazhatók. Tapasztalatokra alapozva bemutatásra kerül hogy, hogyan motiválhatók a diákok – a sajátos felhő alapú kollaborációs térben – a tanórai munkára úgy, hogy egy ténylegesen működő tanulásmenedzselés keretében a pedagógus elsősorban facilitátorként létezik, s az irányítást – átvitt értelemben és ténylegesen – a tanulók kezébe adja a felhő alapú virtuális környezet segítségével.
En nombre de la protección, la judicialización a través de procesos de Determinación de la Capacidad Jurídica
Authors:   , Torres Jacqueline Elizabeth
Published: April 2024

La tesis expone sobre la judicialización de las personas con padecimiento mental mediante los procesos de Determinación de la Capacidad Jurídica. En líneas generales intenta ser un aporte sobre las intervenciones con las personas con padecimiento mental para el fortalecimiento de los derechos. Mediante el análisis de normas y prácticas en el campo de la salud mental se identifica una tendencia a la judicialización de las personas con padecimiento mental vía los procesos de Determinación de la Capacidad Jurídica, que se inscribe como una política de tratamiento del conflicto social. El fundamento estará marcado por la persistencia del diagnóstico en salud mental asociado a la incapacidad. Se trata de una investigación cualitativa. Se utilizaron las técnicas de observación participante y entrevistas semi-estructuradas.
Estudio comparado de las comunidades parasitarias de peces de arroyos pampeanos como indicadores de salud ambiental y biodiversidad según diferentes usos de la tierra
Authors:   , Croci Yasmin
Published: April 2024

El objetivo general de la presente tesis fue estudiar el grado en el cual las comunidades parasitarias de peces en ambientes dulceacuícolas pampeanos con distinto grado de impacto antrópico pueden utilizarse como indicadores de alteraciones del medio ambiente y la biodiversidad. Al examinar la fauna parasitaria de los hospedadores como posibles indicadores de alteraciones ambientales, se observó una notable diversidad en P. rutilus en los arroyos con menos disturbios asociados a sus cuencas. Este hallazgo sugiere la existencia de una amplia diversidad en los ambientes estudiados. Dado su papel como depredador generalista y la sugerencia de varios estudios para utilizarlo en investigaciones sobre impacto antrópico, podríamos proponer a este hospedador para posibles monitoreos dentro de cada entorno, utilizando su fauna parasitaria como indicador de cambios ambientales. En cambio, C. decemmaculatus y C. interruptus presentan un panorama diferente, ya que no se encontró un patrón marcado entre los sitios disturbados. Los parásitos podrían indicar que el ambiente no está muy disturbado o que la alteración ambiental presente no es letal para estos parásitos y sus hospedadores intermediarios y definitivos. Este trabajo sienta las bases para posibles monitoreos dentro de cada ambiente utilizando la fauna parasitaria como indicadora de cambios ambientales. La comprensión de los ciclos de vida, la toma de muestras de agua y sedimentos con la recolección de peces, así como el desarrollo de ensayos en laboratorio con diferentes contaminantes, permitirán inferir con mayor detalle el efecto de estos factores sobre la fauna parasitaria.