bluuebunny/crossref_metadata_2025 huggingface dataset:
MicroRNA-486 promotes a more catabolic phenotype in chondrocyte-like cells by targeting SIRT6
Authors: Yang Jie , Zhou Yunping , Liang Xiaojun , Jing Bingfei , Zhao Zandong
Published: July 2021

Aims

Osteoarthritis (OA) is characterized by persistent destruction of articular cartilage. It has been found that microRNAs (miRNAs) are closely related to the occurrence and development of OA. The purpose of the present study was to investigate the mechanism of miR-486 in the development and progression of OA.

Methods

The expression levels of miR-486 in cartilage were determined by quantitative real-time polymerase chain reaction (qRT-PCR). The expression of collagen, type II, alpha 1 (COL2A1), aggrecan (ACAN), matrix metalloproteinase (MMP)-13, and a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS4) in SW1353 cells at both messenger RNA (mRNA) and protein levels was determined by qRT-PCR, western blot, and enzyme-linked immunosorbent assay (ELISA). Double luciferase reporter gene assay, qRT-PCR, and western blot assay were used to determine whether silencing information regulator 6 (SIRT6) was involved in miR-486 induction of chondrocyte-like cells to a more catabolic phenotype.

Results

Compared with osteonecrosis, the expression of miR-486 was significantly upregulated in cartilage from subjects with severe OA. In addition, overexpressed miR-486 promoted a catabolic phenotype in SW1353 cells by upregulating the expressions of ADAMTS4 and MMP-13 and down-regulating the expressions of COL2A1 and ACAN. Conversely, inhibition of miR-486 had the opposite effect. Furthermore, overexpression of miR-486 significantly inhibited the expression of SIRT6, confirming that SIRT6 is a direct target of miR-486. Moreover, SW1353 cells were transfected with small interfering RNA (si)-SIRT6 and it was found that SIRT6 was involved in and inhibited miR-486-induced changes to SW1353 gene expression.

Conclusion

Our results indicate that miR-486 promotes a catabolic phenotype in SW1353 cells in OA by targeting SIRT6. Our findings might provide a potential therapeutic target and theoretical basis for OA. Cite this article: Bone Joint Res 2021;10(7):459–466.
Are orthopaedic providers willing to work overtime to address COVID-19-related patient backlogs and financial deficits?
Authors: Montgomery Zachary A. , Yedulla Nikhil R. , Koolmees Dylan , Battista Eric , Parsons III Theodore W. , Day Charles S.
Published: July 2021

Aims

COVID-19-related patient care delays have resulted in an unprecedented patient care backlog in the field of orthopaedics. The objective of this study is to examine orthopaedic provider preferences regarding the patient care backlog and financial recovery initiatives in response to the COVID-19 pandemic.

Methods

An orthopaedic research consortium at a multi-hospital tertiary care academic medical system developed a three-part survey examining provider perspectives on strategies to expand orthopaedic patient care and financial recovery. Section 1 asked for preferences regarding extending clinic hours, section 2 assessed surgeon opinions on expanding surgical opportunities, and section 3 questioned preferred strategies for departmental financial recovery. The survey was sent to the institution’s surgical and nonoperative orthopaedic providers.

Results

In all, 73 of 75 operative (n = 55) and nonoperative (n = 18) providers responded to the survey. A total of 92% of orthopaedic providers (n = 67) were willing to extend clinic hours. Most providers preferred extending clinic schedule until 6pm on weekdays. When asked about extending surgical block hours, 96% of the surgeons (n = 53) were willing to extend operating room (OR) block times. Most surgeons preferred block times to be extended until 7pm (63.6%, n = 35). A majority of surgeons (53%, n = 29) believe that over 50% of their surgical cases could be performed at an ambulatory surgery centre (ASC). Of the strategies to address departmental financial deficits, 85% of providers (n = 72) were willing to work extra hours without a pay cut.

Conclusion

Most orthopaedic providers are willing to help with patient care backlogs and revenue recovery by working extended hours instead of having their pay reduced. These findings provide insights that can be incorporated into COVID-19 recovery strategies. Level of Evidence: III Cite this article: Bone Jt Open 2021;2(7):562–568.
Three-dimensional see-through augmented-reality display system using a holographic micromirror array
Authors: Darkhanbaatar Nyamsuren , Erdenebat Munkh-Uchral , Shin Chang-Won , Kwon Ki-Chul , Lee Kwon-Yeon , Baasantseren Ganbat , Kim Nam
Published: July 2021

It is difficult to find the micromirror array with desired specifications for augmented-reality displays, and the custom fabricating methods are complicated and unstable. We propose a novel, to our knowledge, three-dimensional see-through augmented-reality display system using the holographic micromirror array. Unlike the conventional holographic waveguide-type augmented-reality displays, the proposed system utilizes the holographic micromirror array as an in-coupler, without any additional elements. The holographic micromirror array is fabricated through the simple, effective, and stable method of applying the total internal reflection-based hologram recording using a dual-prism. The optical mirror and microlens array are set as references, and the specifications can be customized. It reconstructs a three-dimensional image from a displayed elemental image set without using any additional device, and the user can observe a three-dimensional virtual image while viewing the real-world objects. Thus, the principal advantages of the existing holographic waveguide-type augmented-reality system are retained. An optical experiment confirmed that the proposed system displays three-dimensional images exploiting the augmented-reality system simply and effectively.
Blood groups of Neandertals and Denisova decrypted
Authors: Condemi Silvana , Mazières Stéphane , Faux Pierre , Costedoat Caroline , Ruiz-Linares Andres , Bailly Pascal , Chiaroni Jacques
Published: July 2021

Blood group systems were the first phenotypic markers used in anthropology to decipher the origin of populations, their migratory movements, and their admixture. The recent emergence of new technologies based on the decoding of nucleic acids from an individual’s entire genome has relegated them to their primary application, blood transfusion. Thus, despite the finer mapping of the modern human genome in relation to Neanderthal and Denisova populations, little is known about red cell blood groups in these archaic populations. Here we analyze the available high-quality sequences of three Neanderthals and one Denisovan individuals for 7 blood group systems that are used today in transfusion (ABO including H/Se, Rh (Rhesus), Kell, Duffy, Kidd, MNS, Diego). We show that Neanderthal and Denisova were polymorphic for ABO and shared blood group alleles recurrent in modern Sub-Saharan populations. Furthermore, we found ABO-related alleles currently preventing from viral gut infection and Neanderthal RHD and RHCE alleles nowadays associated with a high risk of hemolytic disease of the fetus and newborn. Such a common blood group pattern across time and space is coherent with a Neanderthal population of low genetic diversity exposed to low reproductive success and with their inevitable demise. Lastly, we connect a Neanderthal RHD allele to two present-day Aboriginal Australian and Papuan, suggesting that a segment of archaic genome was introgressed in this gene in non-Eurasian populations. While contributing to both the origin and late evolutionary history of Neanderthal and Denisova, our results further illustrate that blood group systems are a relevant piece of the puzzle helping to decipher it.
Registered report protocol: Developing an artifact index for capacitive electrocardiography signals acquired with an armchair
Authors: Warnecke Joana M. , Wang Ju , Cakir Tolga , Spicher Nicolai , Ganapathy Nagarajan , Deserno Thomas M.
Published: July 2021

Continuous monitoring of an electrocardiogram (ECG) in private diagnostic spaces such as vehicles or apartments allows early detection of cardiovascular diseases. We will use an armchair with integrated capacitive electrodes to record the capacitive electrocardiogram (cECG) during everyday activities. However, movements and other artifacts affect the signal quality. Therefore, an artifact index is needed to detect artifacts and classify the cECG. The unavailability of cECG data and reliable ground truth information requires new recordings to develop an artifact index. This study is designed to test the hypothesis: an artifact index can be devised, which intends to estimate the signal quality of segments and classify signals. In a single-arm study with 44 subjects, we will record two activities of 11-minute duration: reading and watching television. During recording, we will capture cECG, ECG, and oxygen saturation (SpO2) with time synchronization as well as keypoint-based movement indicators obtained from a video camera. SpO2 provides additional information on the subject’s health status. The keypoint-based movements indicate artifacts in the cECG. We will combine all ground truth data to evaluate the index. In the future, we aim at using the artifact index to exclude cECG segments with artifacts from further analysis. This will improve cECG technology for the measurement of cardiovascular parameters.
Prophylactic anticoagulants to prevent venous thromboembolism in patients with nephrotic syndrome—A retrospective observational study
Authors: Welander Frida , Holmberg Henrik , Dimény Emöke , Jansson Ulf , Själander Anders
Published: July 2021

Background

Nephrotic syndrome (NS) is associated with increased risk of venous thromboembolism (VTE). Guidelines suggest prophylactic anticoagulants to patients with high risk of thrombosis and low risk of bleeding, but the evidence behind this is poor. This study aims to investigate the effectiveness and risks of prophylactic anticoagulants (PAC) and investigate risk factors for VTE and bleeding in NS.

Methods

A retrospective medical records study including adults with NS, biopsy proven glomerular disease in the county of Västernorrland, Sweden. Outcomes were VTE, bleeding and death. Patients divided into PAC- and no PAC group were compared using Fisher’s exact test. Patient time was divided into serum/plasma(S/P)-albumin intervals (<20g/L and ≥20g/L) and VTE- and bleeding rates were calculated.

Results

In 95 included NS patients (PAC = 40, no PAC = 55), 7 VTE (7.4%) and 17 bleedings (18%) were found. Outcomes didn’t differ significantly between the PAC and no PAC group. Time with S/P-albumin <20g/L conferred higher rates/100 years of VTE (IRR 21.7 (95%CI 4.5–116.5)) and bleeding (IRR 5.0 (1.4–14.7)), compared to time with S/P-albumin>20g/L.

Conclusion

Duration of severe hypoalbuminemia (S/P-albumin <20g/L) in NS is a risk factor for both VTE and bleeding. There is a need for randomized controlled studies regarding the benefit of PAC in NS as well as risk factors of thrombosis and bleeding in NS.
Efficacy of the Chinese version interpretation bias modification training in an unselected sample: A randomized trial
Authors: Zhang Fan , Huang Chenwei , Mao Xiaofei , Hou Tianya , Sun Luna , Zhou Yaoguang , Deng Guanghui
Published: July 2021

Training individuals to interpret ambiguous information in positive ways might be an effective method of reducing social anxiety. However, little research had been carried out in Chinese samples, and the effect of interpretation training on other processes such as attentional bias also remained unclear. This study examined the effect of interpretation bias modification program (IMP) on interpretation bias, social anxiety and attentional bias, and the possible mediation effects. 51 healthy adults were randomly assigned to either a 5-session IMP training that guided them to endorse benign interpretation in ambiguous scenarios or an interpretation control condition (ICC). Self-reported measures of social anxiety symptoms, attentional bias and interpretation bias were evaluated before and after training. Results showed that compared to control group, IMP group generated more positive interpretations and less negative interpretations after training (F(1,49) = 7.65,p<0.01, ηp2= 0.14;F(1,49) = 14.60,p<0.01, ηp2= 0.23respectively). IMP yielded greater interpretation bias reduction (F(1,49) = 12.84,p<0.01, ηp2= 0.21) and social anxiety reduction (F(1,49) = 21.39,p<0.01, ηp2= 0.30) than ICC, but change in attentional bias was not significant between IMP and the control group. Change in interpretation bias did not show a significant mediation effect in the relationship between training condition and social anxiety reduction. This study provided preliminary evidence for the efficacy of the Chinese version of IMP training. Possible methodological issues and interpretations underlying the findings were discussed. This study was registered in Chinese Clinical Trial Registry (www.chitr.org.cn), a WHO approved registry. The title of registration trial was “A Study on the efficiency of cognitive bias and attentional bias training on fear and phobia” and the registration number was ChiCTR2100045670.
The effect of pregnancy and the duration of postpartum convalescence on the physical fitness of healthy women: A cohort study of active duty servicewomen receiving 6 weeks versus 12 weeks convalescence
Authors: DeGroot David W. , Sitler Collin A. , Lustik Michael B. , Langan Kelly L. , Hauret Keith G. , Gotschall Michael H. , Gehrich Alan P.
Published: July 2021

Introduction

Pregnancy profoundly affects cardiovascular and musculoskeletal performance requiring up to 12 months for recovery in healthy individuals.

Objective

To assess the effects of extending postpartum convalescence from 6 to 12 weeks on the physical fitness of Active Duty (AD) soldiers as measured by the Army Physical Fitness Test (APFT) and Body Mass Index (BMI).

Methods

We conducted a retrospective study of AD soldiers who delivered their singleton pregnancy of ≥ 32weeks gestation at a tertiary medical center. Pre- and post-pregnancy APFT results as well as demographic, pregnancy, and postpartum data were collected. Changes in APFT raw scores, body composition measures, and failure rates across the 6-week and 12-week convalescent cohorts were assessed. Multivariable regressions were utilized to associate risk factors with failure.

Results

Four hundred sixty women met inclusion criteria; N = 358 in the 6 week cohort and N = 102 in the 12 week cohort. Demographic variables were similar between the cohorts. APFT failure rates across pregnancy increased more than 3-fold in both groups, but no significant differences were found between groups in the decrement of performance or weight gain. With the combined cohort, multivariable regression analysis showed failure on the postpartum APFT to be independently associated with failure on the pre-pregnancy APFT (OR = 16.92, 95% CI 4.96–57.77), failure on pre-pregnancy BMI (OR = 8.44, 95% CI 2.23–31.92), elevated BMI at 6–8 weeks postpartum (OR = 4.02, 95% CI 1.42–11.35) and not breastfeeding at 2 months (OR = 3.23, 95% CI 1.48–7.02). Within 36 months of delivery date, 75% of women had achieved pre-pregnancy levels of fitness.

Conclusion

An additional 6 weeks of convalescence did not adversely affect physical performance or BMI measures in AD Army women following pregnancy. Modifiable factors such as pre- and post-pregnancy conditioning and weight, weight gain in pregnancy and always breastfeeding were found to be significant in recovery of physical fitness postpartum.
Jojo, Jimmy and Marie Chairne: What scribbled comics can (not) tell us
Authors: Crucifix Benoît
Published: July 2021

With two scribbled comics in hand, this article considers material uses and reading practices in Belgian comics culture. As doodles and marks left on battered copies, scribbles foreground complex questions for the comics historian, offering clues to understanding childhood reading practices that otherwise remain elusive.
Graphic panelling and the promotion of transnational affiliations in Thien Pham’s Sumo
Authors: Chiu Monica
Published: July 2021

In Thien Pham’s comic Sumo, simple graphics, iconic figures and limited dialogue assist in efficiently conceptualizing the notion of the transitive, the ability to convey meaning, to allow images to translate concepts quickly, including that of transnationalism itself. Character Scott, a failed American football player, relocates to Japan to take up sumo. His physical transnational move and eventual accommodation to a new sport, new city and new friends are reflected in Pham’s loose OuBaPo form: sections of the comic occurring in Japan and those in the United States follow a fairly strict panel count, diminishing evenly as the narrative progresses, suggesting Scott’s amalgamation of and acceptance in the East from his arrival from the West. But neither is privileged in Pham’s use of nearly equal numbers of panels representing Scott’s past in the United States, present in Japan and future in a smooth amalgamation of football and sumo, East and West, strength and flexibility, failure and success. Sumo uses efficient visual approaches – the unique play inherent in OuBaPo as a drawing exercise in constraints, colour-coded panels and iconicity – to accommodate and unify race and national differences.
Interview with Argha Manna
Authors: Bhattacharjee Partha , Tripathi Priyanka
Published: July 2021

Argha Manna is a cancer-researcher-turned cartoonist. He worked as a research fellow at Bose Institute, India. After leaving academic research, he joined a media-house and started operating as an independent comics artist. He loves to tell stories from the history of science, social history and lab-based science through visual narratives. His blog, Drawing History of Science (https://drawinghistoryofscience.wordpress.com), has been featured by Nature India. Argha has been collaborating with various scientific institutes and science communicator groups from India and abroad. His collaborators are from National Centre for Biological Science (NCBS, Bangalore), Centre for Cellular and Molecular Biology (CCMB, Hyderabad), Jadavpur University (Kolkata), Heidelberg Center for Transcultural Studies (University of Heidelberg, Germany) and a few others. Last year, he received STEMPeers Fellowship for creating comics on the history of vaccination and other aspects of medical histories, published in Club SciWri, a digital publication wing of STEMPeers Group. Currently, Argha is collaborating in a project, ‘Famine Tales from India and Britain’ as a graphic artist. This is a UK-based project, funded by the Arts and Humanities Research Council, led by Dr Ayesha Mukherjee, University of Exeter. In this interview, Partha Bhattacharjee and Priyanka Tripathi speak with Indian ‘alternative’ cartoonist Argha Manna to trace his journey from a cancer researcher to a cartoonist. Manna is a storyteller of history of science, in visuals. Recently, his works reflect social problems under the light of historical and scientific theories. Bhattacharjee and Tripathi trace Manna’s shift from a science-storyteller in a visual medium to a medical-cartoonist who is working on issues related to a global pandemic, its impact on life and literature vis-à-vis social intervention. They also focus on Manna’s latest comics on COVID-19.
Bertsolari txapelketen distortsioak: lehia arautua komunikazioaren kaltetan
Authors: Matxain Kepa
Published: July 2021

90eko hamarkadatik egundaino bertsolaritzaren kategorizazioaz gogoetatu dutenen artean agerikoa da kontsentsua: bertsoa komunikazio-ekintza da, batez ere. Bertsolariak ingurukoekin komunikatu nahi du, bertsokidearekin bezainbat entzuleekin, eta, era berean, ingurukoen erreakzioak zuzenean eragiten dio bertsolariari. Hortik iragankortasuna: une jakin batean toki jakin batean gertatzen da bertsoaren ekintza, eta behin komunikazio zuzen hori gauzatutakoan, betiko desagertzen da. Bertsolari-txapelketak fenomeno aski berriak dira, bai behintzat egun nagusi den formatuan. 1935eko Bertso Gudua izan zen egungo Txapelketa Nagusien aurrekaria ezarri zuena, bertso-mundutik kanpoko eragileek antolatua, bertsoaz oso bestelako interesek bultzaturik –gerraurreko kultur eliteek bertsolaritzara jo zuten euskara eta euskal “espiritua” pizteko asmoz–. 80ko hamarkadatik aurrera egonkortu egin dira bertsolari-txapelketak, eta, egun, bertso-munduko ekitaldi pisutsuenak bilakatu dira, bai ikusgarritasun aldetik, bai sinbolikoki ere. Baina lehia arautua jokoan sartzean, hainbat distortsio gertatzen dira bertsoak hain berezko duen komunikazio-dimentsioan.
urrutiko hezkuntza. CoViD-19aren eragina bigarren Hezkuntzan
Authors: Gamarra Ainhize
Published: July 2021

Artikulu honek urrutiko hezkuntzara bat-batean aldatzeak hezkuntza kalitatean izan duen eragina ikerketzea du helburu, hain zuzen ere Bigarren Hezkuntzan (DBH eta Batxilergoan) EAEn. COVID-19aren pandemia dela eta, ikasketa-zentro guztiak itxi eta biztanleria etxean konfina-tuta egon behar izan denez, urrutiko hezkuntza beharrezkoa bihurtu da. Bigarren Hezkuntzako ikasleek eta irakasleek beti hezkuntza presentzialean lan egin dute, eta ez dute inoiz urrutiko hezkuntzarekin au-rreko kontakturik izan, salbuespen gutxi izan ezik. Horregatik, urrutiko hezkuntzara egokitzeko proze-sua eta haren ondorioak aztertuko dira, eta lortutako emaitzak eta ondorioak erakutsiko. Era horretan, hezkuntza kalitatean izandako eragina ezagutzeko, adierazitako egoera aztertzen da, bai ikasleen, bai irakasleen ikuspuntutik metodologia kuantitatiboa eta kualitatiboa erabiliz.
golden 5 elkarbizitza programa: aritutako irakasleen ikuspegia
Authors: Gaskue Sara , Ibañez-Etxeberria Alex
Published: July 2021

Egungo hezkuntzak aniztasunari, gatazkei eta ikasleen errendimendu zein motibazio hobekuntzari erantzuna emateko erronka du eta hori gainditzeko modurik onena prebentzioa da. Horre-tarako, ezinbestekoa da eskolan elkarbizitza positiboa izatea eta zeregin horretan irakasleek laguntzai-letzat izan dezakete Golden 5 elkarbizitza programa. Bertan gelaren kudeaketa, irakasle-ikasle harre-manak, berdinen artekoak, ikaskuntza doitua eta irakasle-familia harremanak lantzen dira. Esan beharra dago nahiz eta urte batzuetan indarrean egon den, pixkanaka eskoletan presentzia galduz joan dela pro-grama. Ikerketa honen bitartez, Golden 5 programarekin lan egindako irakasleek honen inguruan egiten duten balorazioa ezagutu nahi izan da. Horretarako, Haur Hezkuntzan, Lehen Hezkuntzan eta Derrigo-rrezko Bigarren Hezkuntzan lanean diharduten 7 irakaslerekin elkarrizketa erdiegituratuak mantendu dira eta irakasleek programaren inguruko ikuspegi orokor positiboa dutela eta honek parte hartzaile guztiengan eragin positiboak izan dituela azaleratu da. Halaber, ikusi ahal izan da nola eskoletan inple-mentazioa zailtzen duen ratio handia eta irakas-zama garrantzitsua izateaz gain, zentroen nahiz Berri-tzeguneen jarraipena falta izan den. Hala ere, indibidualki bada ere, egun programarekin lanean dihar-dute zenbait irakaslek.
Hegoaldeko Haur eta Lehen Hezkuntza graduetako ikasleen eleaniztasun-usteak
Authors: Gartziarena Mikel , Altuna Jon
Published: July 2021

Eleaniztasuna kontu arrunta izan da Europan zehar, eta Euskal Herrian ere ez da sal-buespen. Euskal Autonomia Erkidegoan hirueletasuna da jomuga: euskara, espainola eta ingelesa; eta Nafarroako Foru Komunitatean, egoera soziolinguistikoa eta zonifikazioaren mugak tarteko, ere bai. Euskal hezkuntzak euskararen ezagutza, transmisioa eta erabilera hedatzen ditu D ereduaren bitartez, eta globalizazio eta eleaniztasunaren aroan berebiziko erronka aurkezten zaio, euskara ardatz duen es-kola eleanitza sortu, bere egin eta proposatzerakoan. Honako azterlan honetan, EAE eta Nafarroako Foru Komunitateko Haur eta Lehen Hezkuntza graduetako ikasleen (etorkizuneko irakasleen) eleaniz-tasun-usteak ikertzen dira. Ikuspegi kuantitatiboa oinarri, 11 itemeko online-galdetegia diseinatu da, eta 564 gradu-ikasleren usteak jaso dira eleaniztasunaren bueltan. Hala, eskuarteko ikerketak helburu du etorkizunean irakasle izango direnen usteak deskribatzea, euskara erdigune izaki, eta uste horien erroa ikuspegi eleanitzetik ala elebakarretik gertuago ote diren aztertzeko. Etorkizuneko irakasleen us-teetan sakontzeak haien jarrerak, irakas-jarduerak eta balioak hobeto ulertzea Dakar.
La participación ciudadana y el pago voluntario de los impuestos
Authors: Alarcón García Gloria , Mayor Balsas José Manuel , Ayala Gaytán Edgardo Arturo
Published: July 2021

Prácticamente la totalidad de los trabajos sobre cumplimiento tributario que han tenido presente a la participación ciudadanía se han limitado a analizar las diferencias entre residir o no en un sistema de democracia directa. Sin embargo, este hecho deja al margen la propia participación individual, dado que solo se considera la existencia de oportunidades para participar. Con el presente trabajo se pretende dar un pequeño paso aportando nueva evidencia empírica. Partiendo de una muestra de 530 observaciones y mediante un modelo probit se concluye que los individuos que participan activamente en la vida pública muestran una mayor conciencia fiscal.
A discursive approach to bullying from the perspective of Social Work
Authors: Domínguez Laura , Millán-Franco Mario
Published: July 2021

The objective of this study was to explore the social framework of bullying using the discourse of the different agents involved. A qualitative method was used (i.e. thematic analysis). We collected information from 25 semi-structured interviews. Four themes were identified: “Descriptive elements of bullying”; “Bullying is a social issue”; “Normalizing bullying hidden behind other types of violence”, and “An integrated struggle against bullying”. This study shows that bullying is a social problem associated with other types of violence. Bullying should also be studied from the perspective of Social Work to generate new strategies and effective social intervention and prevention programs.
A.C./ D.C. Redes virtuales de solidaridad vecinal ante la COVID-19
Authors: González Tanco Eva María
Published: July 2021

La emergencia sanitaria por la pandemia de la COVID-19 ha causado en España una situación inédita de confinamiento poblacional general y distanciamiento físico. Sin embargo, no se puede hablar de un “distanciamiento social”, como demuestran las múltiples iniciativas de solidaridad dinamizadas en las redes sociales virtuales, que cobran protagonismo por su capacidad para mantener los lazos de apoyo mutuo y el tejido social sin poner en riesgo la obligatoria reclusión. La investigación que se presenta utiliza métodos de la etnografía virtual para contextualizar las posibilidades y limitaciones que ofrecen las redes creadas para construir capital social.
An Exploration into the Satiric Significance of Abuse in Selected Nigerian Drama
Authors: Alabi Oluwafemi Sunday
Published: July 2021

A general survey of the contemporary Nigerian theatre and drama reveals that several contemporary Nigerian dramatists have harnessed the art of abuse—invectives— as a device for conveying meanings in their works and achieving their satiric goals. These dramatists create characters that engage abuse to articulate the thematic concerns of their drama, accentuate the conflicts in them, and establish the socio-cultural and political setting of their drama. Although extant works on satiric plays have focused on the use of language, and other satiric devices such as grotesque, irony, burlesque, innuendo, sarcasm, among others (Adeoti 1994; Adenigbo & Alugbin 2020; Mireku-Gyimah 2013; Nyamekye & Debrah 2016), sufficient scholarly attention has not been given to the art of abuse as a trope in Nigerian drama. The article explores the artistic significance of abuse and its forms in selected works of two contemporary Nigerian dramatists: Femi Osofisan’s Altine’s Wrath (2002) and Ola Rotimi’s Who is a Patriot? (2006). These two plays are selected because they manifest ample deployment of the art of abuse and engage various sociopolitical issues. Hence, the article discusses how the art of abuse in these plays projects and addresses such sociopolitical realities as oppression, exploitation, resistance, self-interest versus national interest, and capitalism, among others. The article engages the principles of superiority theory of humour as espoused by Henri Bergson (2003) for textual analysis. It contends and concludes that abuse, as an inherent part of social and human interactions, has been an effective tool in satirising ills in individuals and society at large.
De carimbo em carimbo se conta uma história
Authors: Maynard Bernini Ismael , Loss Miriam Moema , Alves Cuty Jeniffer
Published: July 2021

Este artigo tem por objetivo registrar uma parte da história da Biblioteca da Faculdade de Biblioteconomia e Comunicação da Universidade Federal do Rio Grande do Sul  (Fabico/UFRGS), desde as origens de seu acervo, isto é, das duas Unidades Acadêmicas de onde provém, até o momento atual e a evolução de seus espaços, de acervo, processamento e atendimento. Para isso usa como mote os diversos carimbos (impressos/estampas) encontrados em livros do acervo e demais fontes de informação existentes. Procura com isso recuperar a trajetória dos mais de 60 anos desta Biblioteca que integra o Sistema de Bibliotecas da Universidade Federal do Rio Grande do Sul (SBUFRGS).
Public Green Space Availability in Semarapura Urban Area
Authors: Sadana Dewa Putu Aris , Vipriyanti Nyoman Utari , Sujana I Putu
Published: July 2021

Green Open Space (GOS), especially Public Green Space (PGS), plays an important role in implementing an urban area's sustainability. Until now, there has been no study of determining the PGS Availability in the Semarapura Urban Area. The study aims to determine PGS Availability in the Semarapura Urban Area based on the type, area, percentage, and area distribution of PGS. Data collection techniques in this study were field observations and secondary data surveys. The data analysis technique in this study is the Geographic Information System (GIS) or mapping. The results showed that Public Green Space (PGS) availability in Semarapura Urban Area was only 8.92 percent of Semarapura Urban Area's total area. This study's results can be used as a basis for determining the strategy of providing PGS in Semarapura Urban Area.
A Li–Yau inequality for the 1-dimensional Willmore energy
Authors: Müller Marius , Rupp Fabian
Published: July 2021

By the classical Li–Yau inequality, an immersion of a closed surface in

ℝ
n

{\mathbb{R}^{n}}

with Willmore energy below

8
⁢
π

{8\pi}

has to be embedded. We discuss analogous results for curves in

ℝ
2

{\mathbb{R}^{2}}

, involving Euler’s elastic energy and other possible curvature functionals. Additionally, we provide applications to associated gradient flows.
Strengths and weaknesses in the diagnostic process of endometriosis from the patients’ perspective: a focus group study
Authors: van der Zanden Moniek , de Kok Laura , Nelen Willianne L. D. M. , Braat Didi D. M. , Nap Annemiek W.
Published: July 2021

Objectives

Endometriosis is characterized by a long interval between onset of symptoms and diagnosis. Detailed information about the patients’ perspective on the diagnostic delay of endometriosis is scarce. The aim of this study was to identify strengths and weaknesses in the diagnostic process of endometriosis from the patients’ perspective.

Methods

Qualitative study with semi-structured focus groups. Participants were women between 18 and 45 years old with a recently confirmed diagnosis. The focus groups were audio recorded and fully transcribed. Grounded theory methodology was applied for data analysis.

Results

Six focus groups were organized, in which 23 women participated. Mean time from start of symptoms to diagnosis was 8.5 years. Dominant themes were knowledge about normal menstruation and endometriosis, being believed and acknowledged by medical staff, and collaboration between health care providers including fast referral to a gynaecologist. Barriers to a timely referral and diagnosis were young age, normalization of symptoms and a lack of awareness in general practitioners. Facilitating factors included adequate knowledge and skills of the general practitioner, a desire for pregnancy and persisting in a request for specialist consultation by the patient.

Conclusions

The diagnostic process of endometriosis is hampered by delayed consultation, inadequate appraisal of symptoms by general practitioners and the interaction between patients and medical professionals. Efforts should be made to increase public awareness and to provide medical staff with sufficient knowledge and skills to adequately acknowledge presented symptoms.
Mahler measure of 3D Landau–Ginzburg potentials
Authors: Fei Jiarui
Published: July 2021

We express the Mahler measures of 23 families of Laurent polynomials in terms of Eisenstein–Kronecker series.
These Laurent polynomials arise as Landau–Ginzburg potentials on Fano 3-folds,
sixteen of which define

K
⁢
3

{K3}

hypersurfaces of generic Picard rank 19, and the rest are of generic Picard rank less than 19.
We relate the Mahler measure at each rational singular moduli to the value at 3 of the L-function of some weight-3 newform.
Moreover, we find ten exotic relations among the Mahler measures of these families.
Preparation of Ammonium Oleic Acid Salts and Their Evaluation as Shale Swelling Inhibitors in Water-Based Drilling Fluid
Authors: Zhang Rongjun , Bai Yun , Sun Yan , Du Weichao , Pu Chunsheng , Zhang Jie , Chen Gang
Published: July 2021

In this paper, ammonium oleic acid salts (AOS) were prepared from oleic acid and amines and investigated as low molecular weight shale swelling inhibitors. First, the inhibitory effect of AOS was investigated using the linear expansion test of bentonite. The results show that the inhibitor prepared from oleic acid and tetraethylene pentamine with a molar ratio of 1:2 (AOS-8) has an excellent inhibitory effect on the hydration expansion of bentonite. The inhibitory effect of AOS-8 on bentonite was further investigated in subsequent work steps using various methods, including the linear swelling test of clay and particle distribution measurement. The results show that AOS-8 has superior performance in inhibiting hydration swelling and dispersion of bentonite. With 0.5% AOS-8, the swelling rate was reduced to 37.7%, and the particle size of bentonite in water could be controlled with AOS-8. Finally, the inhibition mechanism of AOS-8 was determined in detail by scanning electron microscopy (SEM) and thermogravimetric analysis (TGA). In water-based drilling fluid, AOS-8 is compatible with conventional additives. It can also significantly improve the lubricating capacity of the mud cake after ageing at 120°C.
Phase Studies and Efficient Recovery of Inorganic Metal Salts from the Microemulsion System Using a Sugar-Based Non-Ionic Surfactant
Authors: Solanki Shehnaz H. , Patil Sandeep R.
Published: July 2021

In the present work, the phase behaviour of the microemulsion system formulated by using water, organic solvent, and a sugar-based non-ionic surfactant was investigated in detail. We have used a sugar-based non-ionic surfactant for formulation of microemulsion, as it is a greener alternative for the formulation of a microemulsion system, owing to the following aspects: a) better physicochemical properties as compared to that of the conventional non-ionic surfactants, b) non-toxicity, and c) biodegradability. The extraction of heavy metal ions from the metal complexes as well as the recovery efficiency of heavy metal ions using a microemulsion system has been investigated. The maximum absorbance values of metal ions, after recovery from the metal complexes, were measured. Moreover, the UV-Visible spectrophotometric studies revealed that the absorbance increases with an increase in metal ion concentration in the aqueous phase while its value decreases with an increase in the concentration of potassium thiocyanate in the aqueous phase after the extraction of the metal ions from the metal complexes. Furthermore, it has also been evaluated that 4.0 mol/L potassium thiocyanate is the optimum concentration required for efficient recovery of 0.05 mol/L cobalt ion as well as nickel ions. The recovery efficiency of cobalt ions was found to be 97%, whereas that of nickel ions was determined to be 94% respectively. In addition to being an environmentally friendly approach, the present work is an economically viable option too, as it deals with the studies related to the extraction and efficient recovery of metal ions.
Aggregation of Surfactants: Catalytic Reinforcement in Oxidation of Unsaturated E-Crotonaldehyde
Authors: Rakshit Atanu , Chowdhury Suman , Acharjee Animesh , Dome Kuheli , Karmakar Kripasindhu , Saha Bidyut
Published: July 2021

In this work, the kinetics of the micellar catalyzed oxidation of the unsaturated aliphatic aldehyde, E-crotonaldehyde in aqueous medium under pseudo 1st-order reaction condition was spectrophotometrically investigated at 25 °C. In the spectrophotometric measurement, the rate of the reaction was recorded by the decreasing intensity of the metallic oxidant, hexavalent chromium [Cr(VI)], in acidic aliquots at 450 nm with varying concentration of surfactants and/or heteroaromatic promoters. Spectral evidences have been produced in favour of the mechanistic approach and the product formation.
Három nővér a 18. század eleji Budáról
Authors: Géra Eleonóra
Published: July 2021

A tanulmány Franz Kokall budai városi vámos és tanácsos leányainak házasságán keresztül mutatja be a házastársi konfliktusok rendezésének lehetőségeit, valamint a polgári házasság állandó „mellékszereplőit”. A legidősebb leány, Isabella nincstelen szerelme helyett a szülei által választott rézműves polgárhoz ment hozzá. A kezdetektől botrányokkal tarkított házassága állandó beszédtémát szolgáltatott a városban. Férje a korábbi kérőjétől érkezett, asszonyszöktetést előkészítő levelekre hivatkozva próbált megszabadulni a feleségétől. Isabella oldalán azonban ott állt városi alkalmazott apja, aki sikeresen képviselte a tanács előtt. A viták ezt követően sem szűntek meg, az apa, az asszony fivére, a bérlőik, a barátok és a szomszédok így vagy úgy részt vettek az eseményekben. Békétlen életük miatt férje hirtelen halálát követően Isabella férjgyilkosság gyanújába keveredett. Apja minden tekintélyére és kezességére szükség volt, hogy ne ítéljék el. Isabella apja segítségével egy szegény polgár neje lett, soha többé nem került a hatóságok látókörébe, mégis egész életében megbélyegzett maradt, akinek a nevét tisztességes ember óvakodott kimondani. Egyik húga, Susanna Helena nővére példájából tanulva közel két évtizeden keresztül tűrte férje méltatlan bánásmódját, míg másik húga, az özvegy von Krempelné támogatásával a tanács elé merte vinni az ügyüket. Az apa és fivérek ekkor már nem éltek, von Krempelné magában nem tudott eredményesen fellépni húga császári hadnagy férjével szemben. Ha mást nem is értek el, mindenesetre jó figyelmeztetés, nyilvános megszégyenülés volt a tanúk kihallgatása a férj számára. Franziska Gertrud von Krempel kisebb-nagyobb kölcsönökkel támogatta a húgáékat és igyekezett ezen a módon biztosítani a családi békét. A két fiatalabb leánytestvér nem feledkezett meg a városi társadalom peremére került nővérükről, haláláig támogatták anyagilag, még a férjükkel is dacolva.
Fotó: Budapest Főváros Levéltára (BFL) IV.1002.z A Nr. 558. 64. p.
„Elégedett vagyok mindennel.”
Authors: Dezső Krisztina , Gergely Zsuzsanna
Published: July 2021

Fotó: Gergely Zsuzsanna
A „modern nő” születése – a leánynevelés és női művelődés históriája
Authors: Mezeiné Rumpf Anita
Published: July 2021

Kéri Katalin: Leánynevelés és női művelődés az újkori Magyarországon (nemzetközi kitekintéssel és nőtörténeti alapozással). Pécs, Kronosz Kiadó, 2018. 745 oldal.
Los filósofos del Quijote
Authors: Vilarroig Martín Jaime , Araya Carlos
Published: July 2021

El trabajo se propone establecer las raíces filosóficas del Quijote por medio de tres estrategias: en primer lugar, buscando el nombre de filósofos relevantes en la obra (Sócrates, Platón, Aristóteles); en segundo lugar, explicitando las referencias a la filosofía escolástica que aparecen en la obra, relativas a la epistemología, la lógica, la metafísica, la teología racional, la antropología, la ética, la política y la estética; por último, presentando los textos filosóficos de referencia que Cervantes poseería en su biblioteca personal, a partir del trabajo de Eisenberg, y dividiendo las influencias en filosofía del amor, filosofía moral y política, filosofía estética, filosofía popular o paremiología y misceláneas .
Niños e infancia en la narrativa de Amparo Dávila
Authors: Muñoz Figueroa Jorge Antonio
Published: July 2021

El propósito de este texto es analizar las representaciones de la infancia en los cuentos de Amparo Dávila (1928). Si bien es cierto que los menores de edad no figuran como protagonistas en la obra de Dávila, en un buen número de relatos se presentan constantes que remiten a lugares comunes sobre la niñez, por ejemplo la inocencia o la felicidad que la caracterizan. No obstante, tales nociones son puestas en duda en la prosa daviliana, tal como ocurre en las narraciones de otros creadores contemporáneos; en una visión de conjunto, constatamos que los escritores de la llamada Generación de medio siglo erosionan la idea de la infancia como una época maravillosa, antes bien, se dan a la tarea de caracterizarla, en numerosos ejemplos, como una etapa de soledad, a veces de abandono. Dentro de las reformulaciones que goza el tema de la infancia a partir de la década de 1950, las aportaciones de la talentosa escritora zacatecana nos alejan de las típicas imágenes de la niñez y nos permiten formular interpretaciones que revelan que los “reyes del hogar” no siempre traen dicha ni disfrutan plenamente la alegría de los primeros años de su vida.
Juan Gelman: la radicalización del lenguaje como vía de denuncia poética
Authors: Castañeda Barrera Eva
Published: July 2021

La poesía latinoamericana de la segunda mitad del siglo XX se desarrolló en un contexto cuya complejidad está dada por múltiples procesos sociales y políticos, uno de los más emblemáticos es las dictaduras militares del cono sur. En este escenario, una nómina importante de escritores acudió a nuevas estrategias para dar cuenta de la violencia ejercida por el régimen. Para efectos de este trabajo, analizaremos algunos de los recursos formales  que sigue el discurso poético de Juan Gelman para representar y criticar la violencia producto de la dictadura argentina.
Ricardo Piglia, Las tres vanguardias
Authors: Ramírez Jorge Alberto
Published: July 2021

Reseña
Acute Citrulline-Malate Supplementation Increases Total Work in Short Lower-Body Isokinetic Tasks for Recreationally Active Females During Menstruation
Authors: Gills Joshua L. , Spliker Blake , Glenn Jordan M. , Szymanski David , Romer Braden , Lu Ho-Cheng , Gray Michelle
Published: July 2021

Gills, JL, Spliker, B, Glenn, JM, Szymanski, D, Romer, B, Lu, H-C, and Gray, M. Acute citrulline-malate supplementation increases total work in short lower-body isokinetic tasks for recreationally active females during menstruation. J Strength Cond Res 37(6): 1225–1230, 2023—Citrulline-malate (CM) exhibits acute ergogenic benefits through nitric oxide production (NO) and augmentation of vasodilatory properties. Nitric oxide is upregulated by estrogen and may influence CM's ergogenic efficacy in women. Therefore, the objective of this study was to evaluate the acute effects of CM supplementation on lower-body isokinetic performance in recreationally active women. Nineteen women (23.5 ± 3.1 years; 164.8 ± 7.0 cm; 61.9 ± 27.4 kg; 28.8 ± 8.1% body fat) completed 2 randomized, double-blind, crossover trials consuming CM (8 g CM + 12 g dextrose) or placebo (12 g dextrose). For testing trials, subjects were in the menstruating portion of the follicular phase of their menstrual cycle. Subjects performed a 5-repetition isokinetic leg extension protocol (5RP) followed by a 50-repetition isokinetic leg extension protocol (50RP), 60 minutes after supplement consumption. Repeated measures analysis of variance analysis showed that CM significantly increased total work completed, relative total work, and total work during maximum repetition compared with placebo (p < 0.05); but no significant performance differences existed between trials for peak torque production (p = 0.14) for the 5RP. No significant differences were identified between trials for peak torque production (p = 0.69) or total work (p = 0.33) completed during the 50RP. CM increased total work completed during the 5RP, but provided no ergogenic benefit during the 50RP in recreationally active menstruating women. CM amplifies power-based resistance exercise performance in women during the follicular phase of the menstrual cycle, potentially because of depressed estrogen levels. Additional research is needed to identify timing efficacy of CM to increase sport performance during each phase of the menstrual cycle.
The Diagnosis Of Diabetic Retinopathy By Means Of Transfer Learning And Fine-Tuned Dense Layer Pipeline
Authors: Abdo Salman Abdulaziz , Mohd Khairuddin Ismail , P.P. Abdul Majeed Anwar , Mohd Razman Mohd Azraai
Published: July 2021

Diabetes is a global disease that occurs when the body is disabled pancreas to secrete insulin to convert the sugar to power in the blood. As a result, some tiny blood vessels on the part of the body, such as the eyes, are affected by high sugar and cause blocking blood flow in the vessels, which is called diabetic retinopathy.  This disease may lead to permanent blindness due to the growth of new vessels in the back of the retina causing it to detach from the eyes. In 2016, 387 million people were diagnosed with Diabetic retinopathy, and the number is growing yearly, and the old detection approach becomes worse. Therefore, the purpose of this paper is to computerize the old method of detecting different classes of DR from 0-4 according to severity by given fundus images. The method is to construct a fine-tuned deep learning model based on transfer learning with dense layers. The used models here are InceptionV3, VGG16, and ResNet50 with a sharpening filter. Subsequently, InceptionV3 has achieved 94% as the highest accuracy among other models.
Assessment of Occupational Stress on Health Workers in Maternal and Infant Hospitals
Authors: Kusumaningtiar Devi Angeliana , Nuraini Siti
Published: July 2021

Background: Stress is a distortion of the body and mind caused by changes and demands of life. During the Covid 19 pandemic it was shown that the highest levels of stress occurred in health workers, nurses and teachers. Excessive amounts of stress can have harmful effects on the body, mind and psychology. The purpose of this study was to determine the description of the occurrence of work stress on health workers in the inpatient room at Hospital. Methods: The study used a cross sectional design, with a sample of 42 health workers. The sampling technique uses total side method with univariate data analysis.  Results: Results with the highest proportion were health workers who experienced work stress as many as 24 respondents (57.1%) which were more dominantly influenced by factors of high workload variation of 31 respondents (73.8%). Conclusions: The hospital is expected to be more aware of the workload and working hours of health workers in order to minimize the risk of work stress.