bluuebunny/crossref_metadata_2025 huggingface dataset:
Photoregulated fluxional fluorophores for live-cell super-resolution microscopy with no apparent photobleaching
Authors: Halabi Elias A. , Pinotsi Dorothea , Rivera-Fuentes Pablo
Published: March 2019

Photoswitchable molecules have multiple applications in the physical and life sciences because their properties can be modulated with light. Fluxional molecules, which undergo rapid degenerate rearrangements in the electronic ground state, also exhibit switching behavior. The stochastic nature of fluxional switching, however, has hampered its application in the development of functional molecules and materials. Here we combine photoswitching and fluxionality to develop a fluorophore that enables very long (>30 min) time-lapse single-molecule localization microscopy in living cells with minimal phototoxicity and no apparent photobleaching. These long time-lapse experiments allow us to track intracellular organelles with unprecedented spatiotemporal resolution, revealing new information of the three-dimensional compartmentalization of synaptic vesicle trafficking in live human neurons.
Benchmark decadal forecast skill for terrestrial water storage estimated by an elasticity framework
Authors: Zhu Enda , Yuan Xing , Wood Andrew W.
Published: March 2019

A reliable decadal prediction of terrestrial water storage (TWS) is critical for a sustainable management of freshwater resources and infrastructures. However, the dependence of TWS forecast skill on the accuracy of initial hydrological conditions and decadal climate forecasts is not clear, and the baseline skill remains unknown. Here we use decadal climate hindcasts and perform hydrological ensemble simulations to estimate a benchmark decadal forecast skill for TWS over global major river basins with an elasticity framework that considers varying skill of initial conditions and climate forecasts. The initial condition skill elasticity is higher than climate forecast skill elasticity over many river basins at 1–4 years lead, suggesting the dominance of initial conditions at short leads. However, our benchmark skill for TWS is significantly higher than initial conditions-based forecast skill over 25 and 31% basins for the leads of 1–4 and 3–6 years, and incorporating climate prediction can significantly increase TWS prediction skill over half of the river basins at long leads, especially over mid- and high-latitudes. Our findings imply the possibility of improving decadal TWS forecasts by using dynamical climate prediction information, and the necessity of using the new benchmark skill for verifying the success of decadal hydrological forecasts.
Environmental degradation of high-temperature protective coatings for ceramic-matrix composites in gas-turbine engines
Authors: Padture Nitin P.
Published: March 2019

The need for higher efficiencies and performance in gas-turbine engines that propel aircraft in the air, and generate electricity on land, is pushing the operating temperatures of the engines to unprecedented levels. Replacing some of the current hot-section metallic components with ceramic-matrix composites (CMCs) is making that possible. A high-temperature ceramic coatings system, that includes environmental-barrier coatings (EBCs), are needed to protect CMCs. However, these coatings undergo degradation in the highly hostile environment of the gas-turbine engine consisting of a combination of high gas temperatures, pressures, and velocities. In addition, there is the ubiquitous presence of steam (a combustion by-product) and occasional ingestion of calcia-magnesia-aluminosilicates (CMASs) in the form of dust, sand, or ash from the environment. Steam can cause corrosion of EBCs, and the molten CMAS deposits can react with the EBCs resulting in their failure. This article provides a perspective on the understanding of these degradation mechanisms, and possible approaches, guided by that understanding, for mitigating the degradation. An outlook on the future challenges and opportunities is presented.
Improved Detection of Visual Field Progression Using a Spatiotemporal Boundary Detection Method
Authors: Berchuck Samuel I. , Mwanza Jean-Claude , Tanna Angelo P. , Budenz Donald L. , Warren Joshua L.
Published: March 2019

Glaucoma is the leading cause of irreversible blindness worldwide and requires regular monitoring upon diagnosis to ascertain whether the disease is stable or progressing. However, making this determination remains a difficult clinical task. Recently, a novel spatiotemporal boundary detection predictor of glaucomatous visual field (VF) progression (STBound) was developed. In this work, we explore the ability of STBound to differentiate progressing and non-progressing glaucoma patients in comparison to existing methods. STBound, Spatial PROGgression, and traditional trend-based progression methods (global index (GI) regression, mean regression slope, point-wise linear regression, permutation of pointwise linear regression) were applied to longitudinal VF data from 191 eyes of 91 glaucoma patients. The ability of each method to identify progression was compared using Akaike information criterion (AIC), full/partial area under the receiver operating characteristic curve (AUC/pAUC), sensitivity, and specificity. STBound offered improved diagnostic ability (AIC: 197.77 vs. 204.11–217.55; AUC: 0.74 vs. 0.63–0.70) and showed no correlation (r: −0.01–0.11; p-values: 0.11–0.93) with the competing methods. STBound combined with GI (the top performing competitor) provided improved performance over all individual metrics and compared to all metrics combined with GI (all p-values < 0.05). STBound may be a valuable diagnostic tool and can be used in conjunction with existing methods.
Author Correction: Differential Assessment of Factor Xa Activity and Global Blood Coagulability Utilizing Novel Dielectric Coagulometry
Authors: Hamada Satomi , Hasegawa Yuki , Oono Ai , Suzuki Anna , Takahashi Naomi , Nishimura Takuro , Koyama Takatoshi , Hagihara Michio , Tohda Shuji , Furukawa Tetsushi , Hirao Kenzo , Sasano Tetsuo
Published: March 2019

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Phase-pure VO2 nanoporous structure for binder-free supercapacitor performances
Authors: Basu Raktima , Ghosh Subrata , Bera Santanu , Das A. , Dhara S.
Published: March 2019

Vanadium oxides are anticipated as a high-performance energy storage electrode due to their coupled double layer and pseudo-capacitative charge storage mechanism. In the present work, we investigated the influence of different structural phases of as-grown VO2 nanoporous structure and corresponding oxidation states on the supercapacitor performance. This nanoporous structure facilitates fast ion diffusion and transport. It is shown that stoichiometric monoclinic VO2, with V oxidation state of +4, provides superior charge storage capacity with a capacitance value of 33 mF/cm2, capacitance retention of 93.7% and Coulombic efficiency of 98.2%, to those for VO2 structures with mixed oxidation states of V5+ and V4+. A comparable high energy density is also recorded for the sample with all V4+. Scanning Kelvin probe microscopy results clarify further the formation of space charge region between VO2 and carbon paper. These key findings indicate the potentiality of binder-free single phase monoclinic VO2 porous structure towards the next-generation micro-supercapacitor application.
DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro
Authors: Verheijen M. , Lienhard M. , Schrooders Y. , Clayton O. , Nudischer R. , Boerno S. , Timmermann B. , Selevsek N. , Schlapbach R. , Gmuender H. , Gotta S. , Geraedts J. , Herwig R. , Kleinjans J. , Caiment F.
Published: March 2019

Though clinical trials for medical applications of dimethyl sulfoxide (DMSO) reported toxicity in the 1960s, later, the FDA classified DMSO in the safest solvent category. DMSO became widely used in many biomedical fields and biological effects were overlooked. Meanwhile, biomedical science has evolved towards sensitive high-throughput techniques and new research areas, including epigenomics and microRNAs. Considering its wide use, especially for cryopreservation and in vitro assays, we evaluated biological effect of DMSO using these technological innovations. We exposed 3D cardiac and hepatic microtissues to medium with or without 0.1% DMSO and analyzed the transcriptome, proteome and DNA methylation profiles. In both tissue types, transcriptome analysis detected >2000 differentially expressed genes affecting similar biological processes, thereby indicating consistent cross-organ actions of DMSO. Furthermore, microRNA analysis revealed large-scale deregulations of cardiac microRNAs and smaller, though still massive, effects in hepatic microtissues. Genome-wide methylation patterns also revealed tissue-specificity. While hepatic microtissues demonstrated non-significant changes, findings from cardiac microtissues suggested disruption of DNA methylation mechanisms leading to genome-wide changes. The extreme changes in microRNAs and alterations in the epigenetic landscape indicate that DMSO is not inert. Its use should be reconsidered, especially for cryopreservation of embryos and oocytes, since it may impact embryonic development.
SnoopLigase peptide-peptide conjugation enables modular vaccine assembly
Authors: Andersson Anne-Marie C. , Buldun Can M. , Pattinson David J. , Draper Simon J. , Howarth Mark
Published: March 2019

For many infectious diseases there is still no vaccine, even though potential protective antigens have been identified. Suitable platforms and conjugation routes are urgently needed to convert the promise of such antigens into broadly protective and scalable vaccines. Here we apply a newly established peptide-peptide ligation approach, SnoopLigase, for specific and irreversible coupling of antigens onto an oligomerization platform. SnoopLigase was engineered from a Streptococcus pneumoniae adhesin and enables isopeptide bond formation between two peptide tags: DogTag and SnoopTagJr. We expressed in bacteria DogTag linked to the self-assembling coiled-coil nanoparticle IMX313. This platform was stable over months at 37 °C when lyophilized, remaining reactive even after boiling. IMX-DogTag was efficiently coupled to two blood-stage malarial proteins (from PfEMP1 or CyRPA), with SnoopTagJr fused at the N- or C-terminus. We also showed SnoopLigase-mediated coupling of a telomerase peptide relevant to cancer immunotherapy. SnoopLigase-mediated nanoassembly enhanced the antibody response to both malaria antigens in a prime-boost model. Including or depleting SnoopLigase from the conjugate had little effect on the antibody response to the malarial antigens. SnoopLigase decoration represents a promising and accessible strategy for modular plug-and-display vaccine assembly, as well as providing opportunities for robust nanoconstruction in synthetic biology.
Optimization of Extraction Technology of Majun Mupakhi Ela and its Effect on Hydrocortisone-induced Kidney Yang Deficiency in Mice
Authors: Reheman Ayinuer , Gao Ze-yu , Tursun Xirali , Pu Xiao-Ping , Wu Tao , He Fei , Zhao Xin , Aisa Haji Akber
Published: March 2019

We used Box-Behnken design-based (BBD) response surface methodology (RSM) in this research to optimize the extraction process of Traditional medicine Majun Mupakhi Ela (MME) and evaluate its effect on hydrocortisone-induced kidney yang deficiency. Three independent parameters were applied to evaluate the maximum phosphodiesterase type 5 (PDE5) inhibition activity of MME extracts in vitro. The optimal processing conditions (extraction time 2 h, solid-liquid ratio 1:16, extraction once) gave a maximum PDE5 inhibition rate of 84.10%, flavonoid content of 0.49 mg/ml, icariin content of 0.028 mg/ml and targeted extraction yield of 26.50%. In animal experiments, MME extracts significantly increased the adrenal mass index, semen weight index, preputial gland weight index, and penis weight index in mice; in the middle and high dose group, the level of serum testosterone increased by 7664.29% and 14207.14% respectively, compared with the model group, and the level of PDE5 decreased by 67.22% and 74.69% respectively compared with the control group. These results indicate that MME has a significant positive effect on the hypothalamus-pituitary-gonadal axis, improve mating ability and not only has inhibits PDE5 activity but also significantly inhibits the expression of PDE5 in penile tissues, potential to become erectile dysfunction (ED) therapies for the clinical management of patients with kidney yang deficiency.
Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women
Authors: Montalvo-Ortiz Janitza L. , Cheng Zhongshan , Kranzler Henry R. , Zhang Huiping , Gelernter Joel
Published: March 2019

There is currently an epidemic of opioid use, overdose, and dependence in the United States. Although opioid dependence (OD) is more prevalent in men, opioid relapse and fatal opioid overdoses have recently increased at a higher rate among women. Epigenetic mechanisms have been implicated in the etiology of OD, though most studies to date have used candidate gene approaches. We conducted the first epigenome-wide association study (EWAS) of OD in a sample of 220 European-American (EA) women (140 OD cases, 80 opioid-exposed controls). DNA was derived from whole blood samples and EWAS was implemented using the Illumina Infinium HumanMethylationEPIC array. To identify differentially methylated CpG sites, we performed an association analysis adjusting for age, estimates of cell proportions, smoking status, and the first three principal components to correct for population stratification. After correction for multiple testing, association analysis identified three genome-wide significant differentially methylated CpG sites mapping to the PARG, RERE, and CFAP77 genes. These genes are involved in chromatin remodeling, DNA binding, cell survival, and cell projection. Previous genome-wide association studies have identified RERE risk variants in association with psychiatric disorders and educational attainment. DNA methylation age in the peripheral blood did not differ between OD subjects and opioid-exposed controls. Our findings implicate epigenetic mechanisms in OD and, if replicated, identify possible novel peripheral biomarkers of OD that could inform the prevention and treatment of the disorder.
Climate-Altered Wetlands Challenge Waterbird Use and Migratory Connectivity in Arid Landscapes
Authors: Haig Susan M. , Murphy Sean P. , Matthews John H. , Arismendi Ivan , Safeeq Mohammad
Published: March 2019

Wetlands in arid landscapes provide critical habitat for millions of migratory waterbirds across the world and throughout their annual cycle. The scope and scale of understanding avian use of these wetlands in conjunction with changes in climate are daunting yet critical to address lest we lose continent-wide migratory pathways. Here, we assess changes in waterbird use of North America’s Pacific Flyway in the Great Basin by examining water availability and climate trends over the past 100 years. We found recent (1980–2015) climate warming has significantly reduced the amount and shifted seasonality of water flowing into wetlands. Further, we found remarkable changes in waterbird species composition over time. We propose that a reduced hydroperiod and lower water quality from reduction in water level and flow limits sites used by waterbirds. These factors reduce chick survivorship as they cannot metabolize saline water, which makes suitable freshwater conditions a limiting resource. Collectively, climate-induced changes in Great Basin wetlands suggest a major shift in freshwater ecosystems, resulting in degradation of a continental migratory route. This work illustrates the importance of examining multi-scale changes in critical regional resources to understand their impact across a hemispheric flyway and provides a model to examine other flyways.
Bridging human chaperonopathies and microbial chaperonins
Authors: Conway de Macario Everly , Yohda Masafumi , Macario Alberto J. L. , Robb Frank T.
Published: March 2019

Chaperonins are molecular chaperones that play critical physiological roles, but they can be pathogenic. Malfunctional chaperonins cause chaperonopathies of great interest within various medical specialties. Although the clinical-genetic aspects of many chaperonopathies are known, the molecular mechanisms causing chaperonin failure and tissue lesions are poorly understood. Progress is necessary to improve treatment, and experimental models that mimic the human situation provide a promising solution. We present two models: one prokaryotic (the archaeonPyrococcus furiosus) with eukaryotic-like chaperonins and one eukaryotic (Chaetomium thermophilum), both convenient for isolation-study of chaperonins, and report illustrative results pertaining to a pathogenic mutation of CCT5.
The calcium channel subunit gamma-4 is regulated by MafA and necessary for pancreatic beta-cell specification
Authors: Luan Cheng , Ye Yingying , Singh Tania , Barghouth Mohammad , Eliasson Lena , Artner Isabella , Zhang Enming , Renström Erik
Published: March 2019

Voltage-gated Ca2+ (CaV) channels trigger glucose-induced insulin secretion in pancreatic beta-cell and their dysfunction increases diabetes risk. These heteromeric complexes include the main subunit alpha1, and the accessory ones, including subunit gamma that remains unexplored. Here, we demonstrate that CaV gamma subunit 4 (CaVγ4) is downregulated in islets from human donors with diabetes, diabetic Goto-Kakizaki (GK) rats, as well as under conditions of gluco-/lipotoxic stress. Reduction of CaVγ4 expression results in decreased expression of L-type CaV1.2 and CaV1.3, thereby suppressing voltage-gated Ca2+ entry and glucose stimulated insulin exocytosis. The most important finding is that CaVγ4 expression is controlled by the transcription factor responsible for beta-cell specification, MafA, as verified by chromatin immunoprecipitation and experiments in beta-cell specific MafA knockout mice (MafAΔβcell). Taken together, these findings suggest that CaVγ4 is necessary for maintaining a functional differentiated beta-cell phenotype. Treatment aiming at restoring CaVγ4 may help to restore beta-cell function in diabetes.
Spin and valley dependent electronic transport in molybdenum disulfide considering up to the second order k-dependent terms: a more exact solution
Authors: Khani H. , Esmaeilzadeh M. , Kanjouri F.
Published: March 2019

Considering up to the quadratic k-dependent terms of the Hamiltonian, we present an analytical solution for transport through any MoS2 single and multi-junctions consisting of any combination of electric and/or ferromagnetic barriers.
Impact of repeated pressurization on virus removal by reverse osmosis membranes for household water treatment
Authors: Torii Shotaro , Hashimoto Takashi , Do An Thuan , Furumai Hiroaki , Katayama Hiroyuki
Published: March 2019

Repeated pressurization caused integrity loss at the surface of reverse osmosis membranes resulting in a dramatic decrease in virus removal.
Sodium-based batteries: from critical materials to battery systems
Authors: Li Fang , Wei Zengxi , Manthiram Arumugam , Feng Yuezhan , Ma Jianmin , Mai Liqiang
Published: March 2019

In this review, we systematically summarize the recent advances in designing cathode/anode materials, exploring suitable electrolyte, and understanding the operation mechanisms of post-sodium batteries (Na–O2, Na–S, Na–Se, Na–CO2) as well as sodium-ion batteries. The current challenges and future perspectives for the sodium-based energy systems are also presented.
Conductive hollow kapok fiber-PPy monolithic aerogels with excellent mechanical robustness for efficient solar steam generation
Authors: Mu Peng , Bai Wei , Fan Yukang , Zhang Zheng , Sun Hanxue , Zhu Zhaoqi , Liang Weidong , Li An
Published: March 2019

‘Kapok fiber-PPy aerogels were prepared by using polypyrrole modification of the Ca2+ crosslinked kapok fiber aerogels. The kapok fiber-PPy aerogels show excellent light absorption, high porosity and mechanical strength’. As a solar steam generator a high energy conversion efficiency of 82.4% was obtained under 1 sun illumination.
Redox mediators: a shuttle to efficacy in metal–O2 batteries
Authors: Landa-Medrano Imanol , Lozano Iñigo , Ortiz-Vitoriano Nagore , Ruiz de Larramendi Idoia , Rojo Teófilo
Published: March 2019

In the search for a new energy strategy, metal–O2 batteries stand out as a potential alternative. To reduce losses due to high overpotential and to improve their performance, redox mediators emerge as a powerful strategy for the commercialization of these promising devices.
Highly enantioselective synthesis of functionalized azepino[1,2-a]indolesviaNHC-catalyzed [3+4] annulation
Authors: Zhu Shi-Ya , Zhang Yuanzhen , Chen Xin-Fa , Huang Jun , Shi Shi-Hui , Hui Xin-Ping
Published: March 2019

The enantioselective [3+4] annulation of 3-formylindol-2-methylmalonates with 2-bromoenals catalyzed by NHCs is described to efficiently synthesise functionalized azepino[1,2-a]indoles.
Retraction: Anomalies in growth of electrodeposited Ni–Fe nanogranular films
Authors: Zubar T. I. , Panina L. V. , Kovaleva N. N. , Sharko S. A. , Tishkevich D. I. , Vinnik D. A. , Gudkova S. A. , Trukhanova E. L. , Trofimov E. A. , Chizhik S. A. , Trukhanov S. V. , Trukhanov A. V.
Published: March 2019

Retraction of ‘Anomalies in growth of electrodeposited Ni–Fe nanogranular films’ by T. I. Zubar et al., CrystEngComm, 2018, 20, 2306–2315.
Enhancing the upconversion luminescence properties of Er3+–Yb3+ doped yttrium molybdate through Mg2+ incorporation: effect of laser excitation power on temperature sensing and heat generation
Authors: Sinha Shriya , Mahata Manoj Kumar , Kumar Kaushal
Published: March 2019

Upconversion luminescence was enhanced by incorporating Mg2+ into Er3+–Yb3+-doped yttrium molybdate and the effect of laser excitation power on temperature sensing and nanoheating was investigated.
Palladium/silver co-catalyzed syn-stereoselective asymmetric ring-opening reactions of azabenzonorbornadienes with amides
Authors: Shen Guoli , Khan Ruhima , Lv Haiping , Yang Yong , Zhang Xia , Zhan Yong , Zhou Yongyun , Fan Baomin
Published: March 2019

The first syn-stereoselective generation of 1,2-diamino dihydronaphthalene derivatives by asymmetric ring-opening reaction of azabenzonorbornadienes is reported.
The influence of siloxane side-chains on the photovoltaic performance of a conjugated polymer
Authors: Heintges Gaël H. L. , Hendriks Koen H. , Colberts Fallon J. M. , Li Mengmeng , Li Junyu , Janssen René A. J.
Published: March 2019

Molecular weight and intrinsic solubility affect the photovoltaic performance for a diketopyrrolopyrrole polymer with mixed alkyl and siloxane side chains.
Synthesis and characterisation of α-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology
Authors: Zaitseva-Kinneberg Joanna I. , Puchert Anke , Pfeifer Yannik , Yan Hao , Yorke Briony A. , Müller-Werkmeister Henrike M. , Uetrecht Charlotte , Rehbein Julia , Huse Nils , Pearson Arwen R. , Sans Marta
Published: March 2019

We report a new synthetic route to a series of α-carboxynitrobenzyl photocaged l-aspartates for application in time-resolved structural biology.
Near-infrared aggregation-induced enhanced electrochemiluminescence from tetraphenylethylene nanocrystals: a new generation of ECL emitters
Authors: Liu Jia-Li , Zhang Jia-Qi , Tang Zhi-Ling , Zhuo Ying , Chai Ya-Qin , Yuan Ruo
Published: March 2019

Tetraphenylethylene nanocrystals as new ECL emitters with near-infrared aggregation-induced enhanced electrochemiluminescence exhibited high ECL efficiency and excellent biocompatibility.
Ultra-high energy storage performance with mitigated polarization saturation in lead-free relaxors
Authors: Yang Letao , Kong Xi , Cheng Zhenxiang , Zhang Shujun
Published: March 2019

A strategy of mitigating polarization saturation is applied to enhance the energy storage properties of Sn-modified NBT–ST relaxor ceramics.
High performance low-dimensional perovskite solar cells based on a one dimensional lead iodide perovskite
Authors: Ma Chunqing , Shen Dong , Huang Bin , Li Xiaocui , Chen Wen-Cheng , Lo Ming-Fai , Wang Pengfei , Hon-Wah Lam Michael , Lu Yang , Ma Biwu , Lee Chun-Sing
Published: March 2019

One-dimensional perovskites enable high performance low-dimensional perovskite solar cells.
High concentration of few‐layer graphene and MoS2 nanosheets using carboxyl methyl cellulose as a high‐performance stabiliser
Authors: Shang Jingqi , Ding Enyong , Xue Feng , Zeng Xingrong , Chen Jiewei , Xu Ning , Zhang Nianchun , Wei Qiushi
Published: March 2019

This work report a facile, rapid and efficient approach to prepare high‐concentration graphene and MoS2 nanosheets through the liquid phase exfoliation of bulk materials with the method of high‐pressure homogenisation assisted by carboxyl methyl cellulose. The few‐layer graphene and MoS2 nanosheets dispersions are prepared under 100 MPa for 10 min at high concentrations up to 1.45 and 0.28 mg/ml. The two nanodispersions could be applied to prepare the polyvinyl alcohol composite with well dispersibility and thermal stability.
Plasma environment effects on K lines of astrophysical interest
Authors: Deprince J. , Bautista M. A. , Fritzsche S. , García J. A. , Kallman T. R. , Mendoza C. , Palmeri P. , Quinet P.
Published: March 2019

Aims. In the context of black-hole accretion disks, the main goal of the present study is to estimate the plasma environment effects on the atomic structure and radiative parameters associated with the K-vacancy states in ions of the oxygen isonuclear sequence.

Methods. We used a time-averaged Debye–Hückel potential for both the electron–nucleus and the electron–electron interactions implemented in the fully relativistic multiconfiguration Dirac–Fock (MCDF) method.

Results. Modified ionization potentials, K thresholds, Auger widths, and radiative transition wavelengths and rates are reported for O I–O VII in plasma environments with electron temperature and density ranges 105−107 K and 1018−1022 cm−3.
Gliese 49: activity evolution and detection of a super-Earth
Authors: Perger M. , Scandariato G. , Ribas I. , Morales J. C. , Affer L. , Azzaro M. , Amado P. J. , Anglada-Escudé G. , Baroch D. , Barrado D. , Bauer F. F. , Béjar V. J. S. , Caballero J. A. , Cortés-Contreras M. , Damasso M. , Dreizler S. , González-Cuesta L. , González Hernández J. I. , Guenther E. W. , Henning T. , Herrero E. , Jeffers S. V. , Kaminski A. , Kürster M. , Lafarga M. , Leto G. , López-González M. J. , Maldonado J. , Micela G. , Montes D. , Pinamonti M. , Quirrenbach A. , Rebolo R. , Reiners A. , Rodríguez E. , Rodríguez-López C. , Schmitt J. H. M. M. , Sozzetti A. , Suárez Mascareño A. , Toledo-Padrón B. , Zanmar Sánchez R. , Zapatero Osorio M. R. , Zechmeister M.
Published: March 2019

Context. Small planets around low-mass stars often show orbital periods in a range that corresponds to the temperate zones of their host stars which are therefore of prime interest for planet searches. Surface phenomena such as spots and faculae create periodic signals in radial velocities and in observational activity tracers in the same range, so they can mimic or hide true planetary signals.

Aims. We aim to detect Doppler signals corresponding to planetary companions, determine their most probable orbital configurations, and understand the stellar activity and its impact on different datasets.

Methods. We analyzed 22 yr of data of the M1.5 V-type star Gl 49 (BD+61 195) including HARPS-N and CARMENES spectrographs, complemented by APT2 and SNO photometry. Activity indices are calculated from the observed spectra, and all datasets are analyzed with periodograms and noise models. We investigated how the variation of stellar activity imprints on our datasets. We further tested the origin of the signals and investigate phase shifts between the different sets. To search for the best-fit model we maximize the likelihood function in a Markov chain Monte Carlo approach.

Results. As a result of this study, we are able to detect the super-Earth Gl 49b with a minimum mass of 5.6 M⊕. It orbits its host star with a period of 13.85 d at a semi-major axis of 0.090 au and we calculate an equilibrium temperature of 350 K and a transit probability of 2.0%. The contribution from the spot-dominated host star to the different datasets is complex, and includes signals from the stellar rotation at 18.86 d, evolutionary timescales of activity phenomena at 40–80 d, and a long-term variation of at least four years.
Comparative behavior of local hyperelastic lowgrade rubbers for low-cost base isolation
Authors: Tavio  , Wijaya Usman
Published: March 2019

As the second largest rubber producer in the world, Indonesia has a very potential opportunity to support the development of rubber base isolation. Various grades of rubber are produced by the local rubber manufacturers starting from the low to high grade rubbers. In the study, the local rubbers were also compared to the rubbers from another developing country, e.g. India. The laboratory test results used to develop the suitable constitutive model for hyperelastic material and then compared to the hyperelastic model of Shahzad et al. Several tests on the local low-grade rubbers have been conducted, namely the uniaxial tensile, planar shear, and equibiaxial tensile tests. From the tests, it can be concluded the behavior of the local low-grade rubber can be fitted with the Ogden model different from the characteristic of rubber tested by Shahzad et al. which was fitted with the Yeoh model.
Effect of length of steel fibers of waste tires on splitting tensile strength of concrete
Authors: Kumar Hindu Aneel , Hussain Ali Tauha , Faisal Habib Agha
Published: March 2019

The increase in volume of vehicles ultimately increases the number of waste tires. The proper disposal or reutilization of waste tires is a challenge. This study is aimed to utilize the steel fibers of waste tires as reinforcement in concrete. Concrete cylinders were cast with addition of different percentages of steel fibers (0-2%) and length (10-20 mm). The fresh and hard properties of concrete reinforced with different percentages of steel fibers and lengths were observed. It is seen that splitting tensile strength of concrete increased with increase in the length of fiber and with the increase in the percentage of fiber. The inclusion of the fibers in concrete causes the reduction in the workability of concrete.
Response prediction of multi-story building using backpropagation neural networks method
Authors: Suryanita Reni , Maizir Harnedi , Firzal Yohannes , Jingga Hendra , Yuniarto Enno
Published: March 2019

The active ground motion in Indonesia might cause a catastrophic collapse of the building which leads to casualties and property damages. Therefore, it is imperative to design the structural response of building against seismic hazard correctly. Seismic-resistant building design process requires structural analysis to be performed to obtain the necessary building responses. However, the structural analysis could be difficult and time-consuming. This study aims to predict the structural response includes displacement, velocity, and acceleration of multi-story building with the fixed floor plan using Backpropagation Neural Network (BPNN) method. By varying the building height, soil condition, and seismic location in 47 cities in Indonesia, 6345 datasets were obtained and fed into the BPNN model for the learning process. The trained BPNN is capable of predicting the displacement, velocity, and acceleration responses with up to 96% of the expected rate.
Experimental study on the properties of highperformance concrete made with class C fly ash
Authors: Alit Karyawan Salain I Made , Sutarja I Nyoman , Arifmawan Sudhiarta Teguh
Published: March 2019

This experimental study presents the properties of highperformance concrete (HPC) made by partially replacing type I Portland cement (OPC) with class C fly ash (CFA). The purpose of this study is to examine, with hydration time, the development of the compressive strength, the splitting tensile strength and the permeability of HPC utilizing different quantity of CFA. Four HPC mixtures, C1, C2, C3, and C4, were made by utilizing respectively 10%, 20%, 30% and 40% of CFA as replacement of OPC, by weight. One control mixture, C0, was made with 0% CFA. The mix proportion of HPC was 1.00 binder: 1.67 fine aggregate: 2.15 coarse aggregate with water to binder ratio 0.32. In each mixture, it was added 5% silica fume and 0.6% superplasticizer of the weight of the binder. Tests of HPC properties were realized at the age of 1, 3, 7, 28, and 90 days. The results indicate that CFA used to partially replace OPC in HPC shows adequate cementitious and pozzolanic properties. The compressive strength and the splitting tensile strength of HPC increase while the permeability coefficient decreases with increasing hydration time. It is found that the optimum replacement of OPC with CFA is 10%, however the replacement up to 20% is still acceptable to produce HPC having practically similar harden properties with control mixture. At this optimum replacement and after 90 days of hydration, the compressive strength, the splitting tensile strength and the permeability coefficient can reach 68.9 MPa, 8.3 MPa and 4.6 E-11 cm/sec respectively. These results are 109%, 101%, and 48% respectively of those of control mixture.
Early strength of various fly ash based concrete in peat environment
Authors: Olivia Monita , Wibisono Gunawan , Saputra Edy
Published: March 2019

Fly ash is a by-product of coal combustion in a power station and usually used as additive or cement replacement material to improve properties of concrete in aggressive environments such as acid, chloride, and sulphate. Peatland is one of acidic environment that is common in Riau province with high organic content and low pH that is damaging for concrete, especially when exposed to concrete at an early age. This paper aims to study the early compressive and tensile strength of the various type of fly ash based concrete subjected to peat water. Seven fly ash-based concrete mixtures investigate were, i.e., geopolymer hybrid using 15% of Ordinary Portland Cement (OPC) as an additive, high volume fly ash using 25%, 50% and 75% of fly ash as cement replacement material, and blended OPC with fly ash with different grade of 15, 21 and 29 MPa. The OPC concrete with a target strength of 20 MPa was a control mix. The OPC based-specimens were cast and cured in water for 28 days before placed in peat water for another 28 days before the testing date. Compressive strength and tensile strength values of the concrete at 7 and 28 days were taken. Results show the type of concrete, fly ash content, and concrete grade significantly influence the early strength properties and resistance of the concrete to the acid attack. Four concrete mixtures with decreasing vulnerability to the attack were distinguished: OPC, high volume fly ash, geopolymer hybrid and blended cement concrete.
Mechanical properties of concrete with substitution of coated styrofoam balls on coarse aggregate
Authors: Herbudiman Bernardinus , Desmaliana Erma , Muhammad Irawan Andhi
Published: March 2019

Substitution of Styrofoam balls on coarse aggregates reduced concrete self-weight. Coating on Styrofoam ball surface makes ball has shell on its surface and could increase the adhesive strength between ball surfaces and cement paste. The coating materials made by mixing of Portland cement and RCC-15 (Residual Catalytic Cracker-15) as pozzolanic material. 20 mm diameter Styrofoam balls are used. Coarse aggregates substituted by 5%, 15%, and 20% Styrofoam balls. The test specimens used three 10x20cm cylinders for each variant. Beam specimens of 15x15x60cm used for bending strength test by third point loading method. The testing of mechanical properties were 7, 14, and 28 days compressive strengths, 28 days split-tensile strengths and 28 days flexural strengths. The experimental results of concrete with various Styrofoam ball substitutions of 5%, 15%, and 20% at 28 days show the average compressive strengths are 27.6 MPa, 24.3 MPa, and 20.3 MPa, the splittensile strengths are 2.5 MPa, 2.2 MPa, and 1.7 MPa, and the flexural strengths are 5 MPa, 4.5 MPa, and 3.8 MPa, respectively. The compression strength could be predicted by density ratio method and air content method. The experimental results show that all of the variants of Styrofoam ball coarse aggregates concrete are adequate to achieve structural strength, and have nearly compressive strengths compared with the prediction by density ratio method and air content method. Styrofoam balls substitution content could be increased to make the concrete density below 1,900 kg/m3 and compressive strength above 17.5 MPa to reach structural lightweight concrete performance.
The use of solar energy for the curing of ferrogeopolymer elements in the semiarid region
Authors: H Simatupang Partogi , Lubalu Petrus , L Sianturi Herry , Bunganaen Wilhelmus
Published: March 2019

Kupang City in Timor Island of Indonesia, as a semiarid area, has abundant solar energy sources. Based on climatology data of Kupang City in 2013-2015, the minimum and maximum average temperatures in Kupang City range from 19.3-34.8oC. Besides, dry seasons last for about 8 months (April-November). This abundance of solar energy is a potential energy resource for the manufacturing of environmentally friendly ferrogeopolymer elements. Based on previous research, the production of geopolymer material can be done optimally with dry curing treatment at 60-80oC for less than 48 hours. Therefore, in this paper, a low-cost, energy efficient oven operated by a solar energy collector was developed. This paper describes a feasibility study of the use of solar energy for curing ferro-geopolymer elements. The ferro-geopolymer elements made were beams with length 600 mm, width 100 mm and height 100 mm. Wire meshes with 6x6mm of opening were used in 5 layers. The solar energy collector system used as an oven was a zinc coated drum which was painted black outwardly and was covered by a glass plate. Using this oven, it was possible to increase the ambient temperature by 1.62 to 2,37 times. Furthermore, this oven can also increase the flexure strength of ferrogeopolymer elements about ± 25.34%. This paper shows good potential use of solar energy in the manufacturing of ferro-geopolymer elements in the semiarid region.
Flexural behaviour of reinforced lightweight concrete beam using hot water pre-treated oil palm shell coarse aggregate
Authors: Dini Sofyani Farah , Handika Nuraziz , Tjahjono Elly , Arijoeni Essy
Published: March 2019

Along with the increasing demand for habitation in Indonesia, the need for concrete as the most favourable housing material is escalating. Oil Palm Shell (OPS) as coarse aggregate material is a possible alternatives material in concrete mix proportions. This possible choice of material not only can fulfil the requirements of the materials, but is also capable of reducing the problem of OPS waste in Indonesia. As OPS concrete compressive strength in previous studies in laboratory is in the range of 20-23 MPa, studies on larger elements of structure become interesting. This research presents flexure behaviour of lightweight concrete beams using OPS replacing natural coarse aggregates under four-point loading application. OPS is firstly pre-treated using hot water at 50°C based on previous research. In this study, a series of tests was conducted on two samples of identical beam with dimension of 15×25×300 cm. This size represents the typical dimension of beam used in two-storey houses in Indonesia. Mechanical response due to bending that occurs in OPS lightweight concrete beam is presented. Observation on the beam is emphasised on the pure bending area.
Mitigation of peat fires utilizing groundwater supply
Authors: Sandhyavitri Ari , Sujatmoko Bambang , Yusa Muhammad , Charly Vito
Published: March 2019

Mitigating the peat fire disasters in Indonesia during the dry season for more than 20 years (1997-2017) have obstructed by the limited accessibility of surface water resources (including water canals and rivers). Hence, there was a need to seek another opportunity to have access for the water for mitigating the peat fires from local shallow aquifer water resources. Various pumping tests have been conducted to explore the potential and characteristics of the shallow aquifer water for mitigating the peat fires in Riau, Indonesia. The groundwater transmission and storage (storativity) were tested using pump tests. The Cooper Jacob (a straight line) method had been applied to analyze the field data. This study has yielded the following results; the water transmissivity (T) was 1145.98 m2/day, water storage (S) coefficient was 1.09 x 10-3, and the deep depth of the shallow aquifer water (from the ground surface) was approximately 10 meter. Hence, this research identified that the potential shallow aquifer water produced from every single well in the surveyed area in Riau may reach 433.4 m3/day. The amount of this water was considered more than enough to extinguish 4 ha of peat fire occurrences.
Mapping the potential for tourism strategic areas to improve the equality of development in Bali
Authors: Jaya Nyoman M. , Anom Wiryasa Ngakan M. , Dewa Ketut Sudarsana , Salain Putu D.P.
Published: March 2019

Government Regulation of the Republic of Indonesia (PPRI number 50/2011) indicates the declaration of the National Tourism Development Master Plan (RIPParNas) from 2010 to 2025. Eighty-eight (88) of the National Tourism Strategic Areas (KSPN)is spread on thirty four (34) provinces throughout the territory of the Republic of Indonesia. The province of Bali contributes greatest foreign exchange for Indonesia through the tourism sector. Eleventh (11th) of KSPN-Bali are reflecting a priority-program of Indonesian Government through equal development of Tourism Strategic Areas. Development for Bali still indicates gap between a remote regency and central city. The moratorium on rapid development of tourism facility in South Bali indicates quite difference with slower development of East and North Bali. Thus, efforts to increase the distribution of development require investigation and identification through mapping the potential of Natural Resources and Cultivation, especially, the area of tourism in South Bali (Denpasar/Badung) compared to East (Karangasem) and North (Buleleng). Literature review, field observation, and semi-structured interview data were analysed by combination of qualitative-verification methods and cognitive-mapping solutions. The result of case study was representing mapping the potentials for natural resources and cultivation that was identified in Sanur (Denpasar), Tulamben-Amed (Karangasem), and Bali-Utara (Buleleng). Therefore, unequal development between each tourism strategic areas would reduce, and in turn, prosperity of social communities would be improving for Bali.
Analytical hierarchy model of institutional structures for development planning of local government in Bali
Authors: Anom Wiryasa Ngakan M. , Jaya Ngakan M.
Published: March 2019

An institutional reflection plays an important role for development planning in accordance with institutional dynamics. The structure of institutional relationships is analysed for planning the local government development by Interpretive Structural Modelling (ISM). Data was taken from applicable laws and regulations with a juridical-normative method. Resulting hierarchical model of institutional structures, including eight (8) institutional elements, of which one (1) element is excluded beyond the seven (7) elements are classified as unstable impact variables. These seven variables seem to be carefully examined, because they have independent impacts on each other, and their feedback influence can expand beyond impact limitations of the ISM. Therefore, the study represents an example of the recent implementation of the ISM method, called Analytical Hierarchy Model of Institutional Structures (AHMIS) for development planning of local government in Bali.
Construction safety performance assessment on construction site through frequency adjusted importance index in Tangerang Selatan
Authors: Fassa Ferdinand , Paramita Sofia Irma
Published: March 2019

The construction industry has a huge contribution to economic growth in the world, including Indonesia. Massive urban development occurs as a result of significant population growth. Along with the rapid development, safety issue in the construction site is often neglected. In 2017, there were found that more than 123 thousand cases of construction site accidents have happened. This numbers has increased by almost 20% compared with the number of accidents in 2016. The purpose of this study is to identify significant safety indicators affecting the construction project in Tangerang Selatan. Based on the literature review, a list of 22 safety indicators was produced. These indicators were used in the questionnaire. The main contribution of this paper is providing safety indicators ranking that affects construction work around Tangerang Selatan. The subject of this research includes contractor and consultant experts who work in construction project around Tangerang Selatan. From the survey, we obtained 41 valid responses which then were analyzed using FAII. As a result, we found that the indicator “the company provides safety training for each worker to act safely” has been considered as the most important safety indicator. It is followed by “the contractor always provides PPE such as helmets, boots, gloves, masks, and other tools that can get me out of an accident”. Then the third result is “there are safeguards on the project site; safety signs, fire extinguishers, and security fences”.
The role of contractor in improving buildability in construction projects in Bali
Authors: I Putu Ari Sanjaya , I Gede Putu Joni , Ariany Frederika
Published: March 2019

Buildability is defined as the optimum use of construction knowledge and experience (time, cost, quality) at the planning, design, procurement, and field implementation stages so that the building can be completed effectively, efficiently and of good quality. The successful application of the buildabbility improvement program depends on the commitment of all members of the project management team to achieve success. The project management team includes the owner of the project planning and implementation. The aim of the research is to find out the important principle of buildability so that the contractor can play a bigger role in improving constructability. Data collection was carried out by questionnaires and interviews. The results of the analysis showed that the role of the contractor in improving buildability was the highest in the factor of Construction knowledge, team expertise and integration.