bluuebunny/crossref_metadata_2025 huggingface dataset:
Systematic Analysis of tRNA-Derived Small RNAs Reveals the Effects of Xuefu-Zhuyu Decoction on the Hippocampi of Rats after Traumatic Brain Injury
Authors: Dai Feng , Tang Tao , Lu Ruohuang , Li Pengfei , Feng Dandan , Hu Mingrui , Wang Yang , Gan Pingping
Published: September 2022

Background. Traumatic brain injury (TBI) is one of the most common neurosurgical diseases and refers to brain function impairment or brain pathological changes induced by external causes. A traditional Chinese medicine, Xuefu-Zhuyu Decoction (XFZYD), has been indicated to harbor therapeutic properties against TBI. Transfer RNA (tRNA)-derived small RNAs, that is, tsRNAs (a group of small RNAs derived from tRNAs), are multifunctional regulatory noncoding RNAs generated under pressure and implicated in the progression of TBI. Methods. A TBI model was successfully constructed using rats. We further performed sequencing and omics analyses to identify novel tsRNAs as drug targets for XFZYD therapy against TBI in the rat hippocampus. qPCR assays were used to further verify the experimental results. Gene Ontology (GO) was used to analyze the signaling pathways of downstream target genes of tsRNAs in the XFZYD-regulated TBI model. qPCR was used to detect the influence of overexpressed tsRNA mimics/inhibitors on their target genes in PC12 cells. Results. Our RNA-Seq data illustrate that 11 tsRNAs were mediated by XFZYD. The experimental data revealed AS-tDR-002004 and AS-tDR-002583 as potential targets for XFZYD therapy and showed that they influenced TBI via the cadherin signaling pathway, cocaine addiction, circadian entrainment, and the nicotine pharmacodynamics pathway. We also confirmed that Pi4kb, Mlh3, Pcdh9, and Ppp1cb were target genes of 2 XFZYD-regulated tsRNAs in the hippocampus of a rat model and PC12 cells. Furthermore, biological function analysis revealed the potential therapeutic effects of tsRNAs, and the results showed that Mapk1 and Gnai1 were related genes for XFZYD therapy against TBI. Conclusion. Our work successfully illuminates the efficiency of XFZYD in the treatment of TBI. The experimental data revealed AS-tDR-002004 and AS-tDR-002583 as potential targets for XFZYD therapy and showed that they influenced TBI via the cadherin signaling pathway, cocaine addiction, circadian entrainment, and the nicotine pharmacodynamics pathway in a TBI rat model.
Comparative Analysis of the Metabolites and Biological Activity of Cultivated and Wild Lignosus rhinocerotis
Authors: Wu Bingmin , Wang Yange , Zeng Lishan , Li Wengkun , An Lin , Li Jingyan , Zhan Ruoting , Kang Huasheng , Liu Li , Lin Ying , Zhang Guifang
Published: September 2022

In this paper, Lignosus rhinocerotis (Cooke) Ryvarden (L. rhinocerotis) cultivated in rice medium (LRR) and in sawdust medium (LRS) was harvested. Then, in terms of the LRR, LRS, and wild L. rhinocerotis (LRW), the total flavonoid contents, total polyphenol contents, total polysaccharide contents, and metabolites were detected; antioxidants of their aqueous extracts and anti‐inflammatory of their polysaccharides were performed. In addition, the possible mechanism of the polysaccharides of L. rhinocerotis inhibiting lung damage was elucidated. The results showed that 32 compounds were characterized in L. rhinocerotis, including flavonoids, terpenoids, lignans, and steroids and there were 20 compounds in cultivated and wild L. rhinocerotis; LRR has the highest total polyphenol and flavonoid contents, as well as ABTS and DPPH scavenging capacity. The total polysaccharide contents and the FRAP scavenging capacity of wild L. rhinocerotis were higher than those of cultivated L. rhinocerotis. The inhibition of polysaccharides of LRW (PLRW) on LPS‐induced MRC‐5 damage was stronger than that of the polysaccharides from cultivated L. rhinocerotis. The PLRW may alleviate lung damage by inhibiting the NLRP3 pathway and thereby suppressing the inflammatory response. In summary, both cultivated and wild L. rhinocerotis are abundant in bioactive components and have antioxidant and anti‐inflammatory activities.
Bio-Inspired C/N/TiO2 Hybrid Composite Heterostructure: Enhanced Photocatalytic Activity under Visible Light
Authors: Gandi Shyam Sundar , Gandi Suman , Parne Saidi Reddy , Lakavat Motilal , Lakkimsetty Nageswara Rao , Gedda Gangaraju
Published: September 2022

The hydrothermal treatment was used to create a natural hierarchical bio-inspired carbon and nitrogen-doped C/N/TiO2 hybrid composite. It is the goal of this work to investigate the photocatalytic activity of bio-inspired C/N/TiO2 hybrid composite. Techniques such as X-ray powder diffraction, scanning electron microscopy, UV-Vis absorption spectroscopy, FTIR, Raman, and photoluminescence spectroscopy were used to explore the structural, morphological, and photocatalysis characteristics of the bio-inspired C/N/TiO2 hybrid composite. By doping carbon and nitrogen, TiO2 nanotubes were able to improve the photocatalyst properties of the C/N/TiO2 hybrid composite, decrease the energy band gap (∼2.55 eV), and result in increased electron transfer efficiency when compared to pure TiO2. The photocatalytic degradation of pollutants (rhodamine B (RhB)) is made possible by the use of a bio-inspired C/N/TiO2 hybrid composite that has high interconnectivity and an easily accessible surface.
Severe Anti-HMG-CoAR Necrotizing Autoimmune Myopathy Secondary to Statin Use
Authors: Pulipati Priyanjali , Reddy Jayakar Kamantha , Husain Syed Ali
Published: September 2022

Immune-mediated necrotizing myopathy is an uncommon but debilitating disease that can be triggered by drugs, toxins, or cancer. It is similar to polymyositis in presentation but is differentiated by findings on muscle biopsy. We present a case of a 79-year-old male on statin therapy who presented with proximal muscle weakness and elevated creatinine kinase (CK) levels. He had a confirmatory muscle biopsy for immune-mediated necrotizing myopathy. Unfortunately, the patient’s condition eventually escalated, involving respiratory and esophageal muscles in spite of prompt diagnosis and treatment.
Noncoding RNAs Associated with PPARs in Etiology of MAFLD as a Novel Approach for Therapeutics Targets
Authors: Kazeminasab Fatemeh , Baharlooie Maryam , Ghaedi Kamran
Published: September 2022

Background. Metabolic associated fatty liver disease (MAFLD) is a complex disease that results from the accumulation of fat in the liver. MAFLD is directly associated with obesity, insulin resistance, diabetes, and metabolic syndrome. PPARγ ligands, including pioglitazone, are also used in the management of this disease. Noncoding RNAs play a critical role in various diseases such as diabetes, obesity, and liver diseases including MAFLD. However, there is no adequate knowledge about the translation of using these ncRNAs to the clinics, particularly in MAFLD conditions. The aim of this study was to identify ncRNAs in the etiology of MAFLD as a novel approach to the therapeutic targets. Methods. We collected human and mouse MAFLD gene expression datasets available in GEO. We performed pathway enrichment analysis of total mRNAs based on KEGG repository data to screen the most potential pathways in the liver of MAFLD human subjects and mice model, and analyzed pathway interconnections via ClueGO. Finally, we screened disease causality of the MAFLD ncRNAs, which were associated with PPARs, and then discussed the role of revealed ncRNAs in PPAR signaling and MAFLD. Results. We found 127 ncRNAs in MAFLD which 25 out of them were strongly validated before for regulation of PPARs. With a polypharmacology approach, we screened 51 ncRNAs which were causal to a subset of diseases related to MAFLD. Conclusion. This study revealed a subset of ncRNAs that could help in more clear and guided designation of preclinical and clinical studies to verify the therapeutic application of the revealed ncRNAs by manipulating the PPARs molecular mechanism in MAFLD.
Effects and Safety of Oral Iron for Heart Failure with Iron Deficiency: A Systematic Review and Meta-Analysis with Trial Sequential Analysis
Authors: Tan Nannan , Cai Yiqing , Liu Junjie , Wang Xiaoping , Ma Lin , Ling Guanjing , Jiang Jinchi , Wang Qiyan , Wang Yong
Published: September 2022

Background. Oral iron supplement is commonly prescribed to heart failure patients with iron deficiency. However, the effects of oral iron for heart failure remain controversial. This study included randomized controlled trials (RCTs) for meta-analysis to evaluate the effects of oral iron for heart failure patients. Methods. Nine databases (The Cochrane Library, Embase, PubMed, CINAHL, Web of science, CNKI, SinoMed, VIP, and Wanfang) were searched for RCTs of oral iron for heart failure from inception to October 2021. The effects were assessed with a meta-analysis using Revman 5.3 software. The trial sequential analysis was performed by TSA 0.9.5.10 beta software. The risk of bias of trials was evaluated via Risk of Bias tool. The evidence quality was assessed through GRADE tool. Results. Four studies including 582 patients with heart failure and iron deficiency were enrolled. The results indicated that oral iron treatment could improve left ventricular ejection fraction (LVEF,

MD
=
1.52
%

, 95% CI: 0.69 to 2.36,

P
=
0.0003

) and serum ferritin (

MD
=
1.64

, 95% CI: 0.26 to 3.02,

P
=
0.02

). However, there was no between-group difference in the 6-minute walk distances (6MWT), N terminal pro B type natriuretic peptide (NT-proBNP) or hemoglobin level when compared with control group. Subgroup analyses revealed that the effects of oral iron on 6 MWT and serum ferritin could not be affected by duration and frequency of oral iron uptakes. In trial sequential analysis of LVEF and serum ferritin, the Z-curves crossed the traditional boundary and trail sequential monitoring boundary but did not reach the required information size. Conclusion. This analysis showed that oral iron could improve cardiac function measured by LVEF, and iron stores measured serum ferritin, but lack of effect on exercise capacity measured by 6 MWT, and iron stores measured by hemoglobin. Given the overall poor methodological quality and evidence quality, these findings should be treated cautiously.
KIAA0101 and IL2RA Were Identified as Core Genes in Hormone-Resistant Nephropathy
Authors: Chen Ying , Qian Shuyi , Chen Yinyin , Liu Kanghan , Yin Wei , Luo Xun
Published: September 2022

Objectives. To analyze the tissue heterogeneity of hormone-sensitive and drug-resistant nephrotic syndrome genes using a bioinformatics approach and to analyze gene-related functional pathways. Methods. The limma package of R software was used to screen differential genes from the nephropathy datasets GSE145969 and GSE189734. The differential genes were analyzed for functional and pathway enrichment in terms of biological processes, cellular components, and molecular functions. The Metascape tool was used to construct protein networks for the differential genes, and the results were imported into Cytoscape software for visualization. The genes were identified as key modules and genes using the MCODE plug-in. Gene set enrichment analysis was performed for the HALLMARK analysis of the two microarray key genes to obtain the relevant pathways. Results. GSE145969 screened 351 differential genes, 168 upregulated genes, and 183 downregulated genes. The differential genes were enriched in biological processes, cellular components, and molecular functions, such as myocardial contraction, intracellular nonmembrane organelles, and structural molecular activities. The protein-protein interaction (PPI) network contained 140 nodes, with the highest-scoring module containing seven genes, and the MCODE plug-in calculated the downseed. The key gene was KIAA0101, whose HALLMARK pathway was significantly enriched in the mTORC1 signaling pathway. A total of 263 differential genes were screened by GSE189734, and they were enriched in biological processes, molecular functions, and cellular components, such as immune system processes, signaling receptor binding, and the cytoplasmic matrix. The PPI network contained 253 nodes, with the highest-scoring module containing 37 genes. The seed gene obtained through the MCODE plug-in calculation was IL2RA, whose HALLMARK pathway was significantly enriched in the KRAS signaling pathway. Conclusion. By analyzing the gene sets of different tissues in nephropathy, two key genes, namely KIAA0101 and IL2RA, were obtained. Their gene function enrichment is related to cell growth, development, and reproduction. Therefore, IL2RA and KIAA0101 can be used as diagnostic markers for hormone-resistant nephropathy.
Shear Performance of Concrete Beams with a Maximum Size of Recycled Concrete Aggregate
Authors: Odero Brian Jacks , Mutuku Raphael N. , Nyomboi Timothy , Gariy Zachary Abiero
Published: September 2022

The use of concrete mixes with recycled materials has gained traction in research communities. However, the major drawback of the recycled concrete aggregate (RCA) has been the contribution of the cement paste mortar attached to the surface. The quantity of surface-attached mortar on the virgin aggregate dominates and defines the shear performance of concrete beams. Concrete shear failure is usually abrupt and catastrophic, especially in concrete beams without shear reinforcement. The effectiveness of the maximum size of RCA for the performance of untreated and treated with pozzolanic cement and rice husk ash (RHA) slurry was investigated. A total of sixteen (16) beams containing RCA of four (4) maximum sizes, 10, 14, 20, and 25 mm, were prepared and tested after 28 days. The beams were loaded in shear using shear span-depth ratios of 1.25 and 2.50. The results showed that the shear strength of the beams increases as the aggregate size increases to a maximum size of 20 mm, beyond which the shear strength reduces. It was attributed to the attached mortar, which increased as the size of the aggregate increased, creating a weak zone for shear failure in the concrete. In addition, RCA pretreatment using slurry-containing cement and RHA strengthened the attached mortar on the aggregate surface. It resulted in a dense and more compact aggregate that slightly improved the shear strength by about 2.2% for beams containing 20 mm RCA size. The ultimate shear strength of the experimental work in the study was predicted using eight (8) selected models from the literature. Models that account for the aggregate size and shear span to depth ratio resulted in shear strength ratios of 1.29, 0.91, 1.08, and 1.20 for Bažant and Becq-Giraudon, 2002, Zsutty, 1968, Xu et al., 2012, and Gastebled and May, 2001, which are almost similar outcomes to the experimental results.
Grid Adaptive Bucketing Algorithm Based on Differential Privacy
Authors: Li Xiangjun , Zhao Xuewen , Zhang Huijuan , Han Jideng
Published: September 2022

With the popularity of location-based services, the restricted relationship between the availability of big location data and user’s privacy security has become a challenging issue. The spatial division is an effective measure for statistical location data characteristics. This paper proposes a grid adaptive bucketing algorithm based on differential privacy (GAB) to solve the problem that the existing differential privacy location data division method does not fully consider the distribution characteristics of spatial data points and noise superimposition. The algorithm first divides the mobile app location spatial data set into two layers of grids. It then performs adaptive binning judgment according to the square sum error value in the divided area. It puts areas with similar distributions into the same bucket, reducing the uniform assumption error and the noise error caused by many blank areas. Finally, a noise allocation strategy based on Hopkins statistic is adopted to achieve a reasonable noise allocation. The experimental results on two real large-scale location data sets, Checkin and Beijing, show that, compared with other classical algorithms based on differential privacy space partitioning, the GAB algorithm performs better in common evaluation indicators such as relative error and absolute error, which means GAB can obtain better range query effects and privacy protection effects.
SaaS Service Combinatorial Trustworthiness Measurement Method Based on Markov Theory and Cosine Similarity
Authors: Gao Tilei , Jia Xiaohui , Jiang Rong , He Yuanyuan , Yang Ming
Published: September 2022

With the rapid progress of information technology, cloud computing and cloud services are widely accepted and applied to all aspects of social life. In the cloud computing environment, SaaS (Software-as-a-Service) services have become the main form of software services. For SaaS services, evolutionary and iterative development methods have become the main methods of software system construction. For systems with high trustworthiness, the independent trustworthiness of each SaaS service has a great impact on the overall status. However, SaaS services with high independent trustworthiness do not always build highly trusted software systems. The combinatorial trustworthiness between SaaS services is as important as the independent trustworthiness of each SaaS service. This paper takes combinatorial trustworthiness between SaaS services as the research object. Combinatorial trustworthiness measurement method based on Markov and cosine similarity theory is proposed. The feasibility and effectiveness of the proposed method are verified through simulation experiments. Applicable scenarios, advantages, and disadvantages of the proposed method are shown through the comparison of different measurement methods. The proposed method provides theoretical and technical support for users to select SaaS services suitable for their application scenarios, build cloud service systems, and monitor the operation status of cloud service systems.
Influence of Evidence-Based Nursing on Psychological Status, Neurological Function, and Life Quality of Patients with Acute Poststroke Depression
Authors: Song Yan , Wang Fei , Yang Yakun , Liu Xing , Zhu Chenghong
Published: September 2022

Objective. This research sets out to elucidate the influence of evidence-based nursing (EBN) on psychological status (PSY), neurological function, and quality of life (QoL) of patients with acute poststroke depression (PSD). Methods. One hundred and fifty stroke patients who received treatment in the Characteristic Medical Center of PLA Rocket Force between December 2019 and December 2021 were enrolled, including 100 cases (Group A) treated with comprehensive EBN and 50 patients (Group B) with routine nursing. Anxiety and depression (Self-Rating Anxiety Scale [SAS] and Self-Rating Depression Scale [SDS] scores), neurological function (National Institutes of Health Stroke Scale [NIHSS] and Scandinavian Stroke Scale [SSS] scores), QoL (Generic Quality Of Life Inventory-74 [GQOLI-74] score), and complication rate of both groups were evaluated, as well as total effective rate and nursing satisfaction. Results. Group A outperformed Group B with lower scores of NIHSS, SSS, SAS, and SDS and higher GOOLI-74 scores. Besides, lower complication rate and higher total effective rate and nursing satisfaction were determined in Group A. Conclusions. EBN can better improve the PSY of patients with acute PSD, restore their neurological function, and effectively improve their QoL.
[Retracted] Pulmonary Magnetic Resonance Imaging Replaces Bedside Imaging in Diagnosing Pneumonia in Infants
Authors: Zhang Haijun , Zhang Yingcui
Published: September 2022

Neonatal Bronchopulmonary Bedside Photography (NBBP) evaluates the consumption of lung magnetic resonance imaging as a replacement for bedside imaging in diagnosing infant pneumonia. In premature baby respiratory support, Neonatal Bronchopulmonary (NB) is one of the most dangerous consequences of accurate diagnosis that impact health alternatives once steroids are administered. Infants may experience eating issues and vomit if their condition is bad enough; lower birth weight, younger gestational age, and extensive breathing tube damage are the most frequently established risk factors as a component of a neonatal habitat. This paper introduces the Intelligent Medical Care (IMC) for Neonatal Bronchopulmonary Bedside Photography (NBBP), which enhances various preventive efforts such as prenatal steroid therapy. Because of many prenatal and postnatal variables, growth hormone and diet nutrients influence alveolar and vascular development. For the future prevention of NB, it is more likely that a combination of different therapies working on diverse causal pathways would be beneficial. This research in NBBP‐IMC technology that enhances prenatal care medicines are the most excellent and effective treatments for all these neonates throughout the decades. As a result, premature babies at risk for NB may benefit from the findings of this research, which experts anticipate can inspire further studies in the area. The purpose of this paper is to emphasize the work performed to improve respiratory outcomes for babies at risk of NB and to place this work in perspective with relevant research currently being conducted simultaneously.
Short-Term Outcomes of Elective High-Risk PCI with Extracorporeal Membrane Oxygenation Support: A Single-Centre Registry
Authors: Griffioen Alexander M. , Van Den Oord Stijn C. H. , Van Wely Marleen H. , Swart Gerard C. , Van Wetten Herbert B. , Danse Peter W. , Damman Peter , Van Royen Niels , Van Geuns Robert Jan M.
Published: September 2022

Background. If surgical revascularization is not feasible, high-risk PCI is a viable option for patients with complex coronary artery disease. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides hemodynamic support in patients with a high risk for periprocedural cardiogenic shock. Objective. This study aims to provide data about short-term outcomes of elective high-risk PCI with ECMO support. Methods. A retrospective single-center registry was performed on patients with high-risk PCI receiving VA-ECMO support. The short-term outcome was defined as the incidence of major adverse cardiac events (MACE) during the hospital stay and within 60 days after discharge. Results. Between January 2020 and December 2021, 14 patients underwent high-risk PCI with ECMO support. The mean age was 66.5 (±2.5) and the majority was male (71.4%) with a mean left ventricular ejection fraction of 33% (±3.0). Complexity indexes were high (STS-PROM risk score: 2.9 (IQR 1.5–5.8), SYNTAX score I: 35.5 (±2.0), SYNTAX score II (PCI): 49.8 (±3.2)). Femoral artery ECMO cannulation was performed in 13 patients (92.9%) requiring additional antegrade femoral artery cannula in one patient because of periprocedural limb ischemia. The mean duration of the ECMO run was 151 (±32) minutes. One patient required prolonged ECMO support and was weaned after 2 days. Successful revascularization was achieved in 13 patients (92.8%). Procedural success was achieved in 12 patients (85.7%) due to one unsuccessful revascularization and one procedural death. MACE during hospital stay occurred in 4 patients (28.6%) and within 60 days after discharge in 2 patients (16.7%). Conclusion. High-risk PCI with hemodynamic support using VA-ECMO is a feasible treatment option, if surgical revascularization is considered very high risk. Larger and prospective studies are awaited to confirm the benefits of ECMO support in elective high-risk PCI comparing ECMO with other mechanical circulatory support devices, including coaxial left cardiac support devices and IABP. Trial Registration. This trial is registered with NCT05387902.
GJD Modulates Cardiac/Vascular Inflammation and Decreases Blood Pressure in Hypertensive Rats
Authors: Mohammed Shadi A. D. , Liu Hanxing , Baldi Salem , Chen Pingping , Lu Fang , Liu Shumin
Published: September 2022

Gedan Jiangya decoction (GJD) (aqueous ethanol extract), a traditional Chinese medicine formula which contain six botanical drugs (Uncaria rhynchophylla (Miq.) Miq., Salvia miltiorrhiza Bunge, Pueraria lobata (Willd.) Ohwi, Eucommia ulmoides Oliv., Prunella vulgaris L., and Achyranthes bidentata Blume) was designed to treat hypertension; however, the underlying mechanism of action is unclear. This study aimed to determine the mechanisms of action of GJD in the treatment of hypertension in spontaneously hypertensive rats (SHR). Male SHRs were randomly divided into five groups: GJD doses were low (1.36 g/kg/d), medium (2.72 g/kg/d), and high (5.44 g/kg/d), captopril (13.5 mg/kg/d), and SHR groups, with Wistar-Kyoto rats (WKY) serving as the control. Every rat was gavaged once a day. The ALC-NIBP, a noninvasive blood pressure device, measured systolic (SBP) and diastolic (DBP) blood pressures. Six weeks following treatment, all rats were anesthetized. The blood samples were obtained from the abdominal aorta and then serum isolated to assess endothelin-1 and angiotensin II, interleukin-1beta, interleukin-6, and TNF-alpha. The left ventricular and thoracic aortas were taken for HE staining, immunohistochemistry, RT-qPCR, and western blot examination. Following GJD therapy, SBP and DBP were significantly lowered, as were serum levels of endothelin-1 and angiotensin II. The thickness of the left ventricular and thoracic aorta walls reduced, as did type I collagen, type III collagen, and alpha-SMA expression in the left ventricular and aortic tissues. The GJD treatment significantly reduced serum levels of the inflammatory markers interleukin-1beta, interleukin-6, and TNF-alpha. Furthermore, interleukin-1 beta, interleukin-6, TNF-alpha, TAK1, and NF-κB/p65 levels were significantly reduced in left ventricular and aortic tissues, whereas IkB-alpha levels were significantly elevated. GJD has a dose-dependent effect on all parameters. In conclusion, GJD has been shown to lower blood pressure, improve cardiovascular remodeling, and reduce inflammation via regulating NF-κB in SHRs.
Mobility and Quality of Life in Chinese Elderly and Geriatric Patients and Biomedical Diagnosis
Authors: Xin Jing , Li Liyuan
Published: September 2022

Mobilization hugely affects the personal satisfaction of old people. We found that preparing old and geriatric patients expands their personal satisfaction using statistical comparisons of observed groups. As a technique of evaluation, we employed the nonparametric Mann–Whitney test. The Pearson correlation coefficient was employed to determine relationships between variables. In both the BREF questionnaire (item 15) and the ADL test, geriatric individuals had similar mobility rates. Physical activity is a crucial feature of mobility in seniors, according to findings from other studies. In hospitalized geriatric patients, reduced mobility is the most significant impediment. Seniors’ confidence in their own talents grew as a result of the favourable overall influence of physical activity. Geriatric patients must be mobilized on a regular basis in nursing, depending on their level of dependency. Physical activity had a positive overall effect on older people’s confidence in their own abilities, and this was shown in how they felt about themselves. Nursing staff must constantly move geriatric patients based on how much assistance they require.
Changes in Patient-Reported Health Status in Advanced Cancer Patients from a Symptom Management Clinic: A Longitudinal Study Conducted in China
Authors: Zhang Yening , Li Zimeng , Pang Ying , He Yi , He Shuangzhi , Su Zhongge , Zhou Yuhe , Wang Yan , Wang Bingmei , Song Lili , Li Jinjiang , Han Xinkun , Zhou Chengcheng , Li Xiumin , Tang Lili
Published: September 2022

Objectives. The integration of patient-reported health status has been increasingly emphasised for delivering high-quality care to advanced cancer patients. This research is designed to track health status changes over time in Chinese advanced cancer patients to explore the risk factors affecting their health status. Methods. Advanced cancer patients were recruited from Peking University Cancer Hospital. An electronic patient-reported outcome (ePRO) system with validated measurements was used to collect the data. ANOVA, the chi-square test, the nonparametric Kruskal–Wallis H test, and generalized estimating equation (GEE) analysis were used for the data analysis. Results. One hundred and three patients completed a baseline survey (T = 0) and two follow-up surveys (T1 = 14 days, T2 = 28 days). Chi-square test results indicate a significant decrease in the percentage of patients reporting moderate or severe difficulty experienced by patients in terms of mobility, pain/discomfort, and anxiety/depression. However, there is a significant increase in the percentage of patients reporting moderate or severe difficulty in self-care and usual activities. Scores on the visual analogue scale in the EQ-5D-5L instrument (EQ-VAS) are associated with patients’ income, and the degree of moderate or severe anxiety/depression is found to be associated with employment status. The GEE results show that pain, loss of appetite, poor walking status effected by symptoms, depression, and anxiety has worsened the health status. Conclusions. The health status of Chinese advanced cancer patients under ePRO follow-up in China significantly improves in the physical and psychological dimensions, accompanied by a decrease in usual activities and self-care. Routine screening and rational supportive care are recommended in oncology for cancer care. Based on the rational application of ePRO, longitudinal studies exploring the potential mechanisms of health status changing would provide more beneficial guidance for improving the quality of life in patients with advanced cancer.
Optimization of Vocal Singing Training Methods Based on Multimedia Data Analysis
Authors: Zhang Dajun , Wang Xiaoning
Published: September 2022

This paper constructs a vocal singing training optimization model based on multimedia data analysis and conducts in-depth research and analysis on the optimization of vocal singing training methods using multimedia data analysis system. For the problems of poor real-time and large analysis error of the traditional system, a massive real-time multimedia data analysis system based on DSP is designed, with high-speed DSP as the core architecture, multipoint modeling of the experimenter, and data extraction and fusion processing are completed with model association characteristics as the analysis basis. The experimental results show that the real-time performance and accuracy of the system are improved by 15.14% and 13.42%, respectively. To address the time-space domain consistency problem in traditional time series data forecasting, two high-order time series forecasting algorithms based on tensor decomposition are proposed in this paper: the multilinear orthogonal autoregressive model and the multilinear constrained autoregressive model. Using the local structure information of the data to reduce the dimensionality of the data is more beneficial to extract the true low-dimensional representation of the data. Most current supervised cross-modal retrieval methods use a strict binary label matrix (i.e., 0 and 1); however, the interval between labels 0 and 1 is small, which may increase the risk of classification errors. To solve some of the above existing problems, a two-stage hashing method based on smooth matrix decomposition and label relaxation is proposed, which proposes a novel label relaxation strategy that can adaptively control the interval between label intervals and can reduce the quantization loss by about 5.21%. The multimedia data analysis vocal singing training optimization model designed in this paper can improve enhance students’ motivation and accuracy and provide technical support and a rational basis for vocal singing practice and overall musical expression.
Application of Low-Dose CT and MRI in the Evaluation of Soft Tissue Injury in Tibial Plateau Fractures
Authors: Qi Yinping , He Peipei , Zhu Jianping , Wang Yanan , Zhao Hong , Chen Junbo
Published: September 2022

Objective. To explore the application value of low-dose CT and MRI in the evaluation of soft tissue injury in tibial plateau fractures. Methods. This study included 89 patients with high suspicion of TPF and KI admitted to our hospital from July 2015 to May 2021. After arthroscopy, 81 patients were diagnosed with FTP combined with KI. The Schatzker classification based on X-ray and CT plain scan combined with three-dimensional reconstruction was recorded, and the soft tissue injury was recorded according to the MRI examination of the affected knee joint. Results. With the results of pathological examination and arthroscopic surgery as the gold standard, the results of MRI and pathological examination and arthroscopic examination were in good agreement (

Kappa
=
0.857
,
0.844

), and CT was moderately in agreement (

Kappa
=
0.697
,
0.694

). In KI examination, CT and MRI had no difference in the evaluation of ligament injury and bone injury (

P
>
0.05

), but MRI had better diagnostic effect on meniscus injury (

P
<
0.05

). Finally, the satisfaction survey showed that patients in the CT group were more satisfied with clinical services (

P
<
0.05

). Conclusion. Both CT and MRI have certain diagnostic value for occult tibial plateau fractures, among which CT examination is more advantageous for trabecular bone fractures, MRI examination is more advantageous for cortical bone fractures, and MRI examination can improve occult tibial plateau fracture inspection accuracy.
Topometry Optimization of Energy Absorbing Structure through Targeting Force-Displacement Method considering Tailor Rolled Blank Process
Authors: Wang Shigen , An Weigang , Lin Tianyu , Han Xu
Published: September 2022

Inspired by topometry optimization, this work proposed a new design approach that mixed of targeting force-displacement (TFD) method and tailor rolled blank (TRB) process for thin-walled energy absorption structures, which has vast applied prospects in the aerospace and automotive industries. This method not only overcomes manufacturing difficulty caused by the TFD method based on topometry optimization but also provides a new idea for TRB energy absorption structure. The optimized results can be transferred to the computer aided design environment without additional postprocessing. Firstly, a uniform thickness constraint is introduced to make the designed structure have constant thickness distribution along desired direction; topometry optimization is carried out to use TFD method. Secondly, a method that can automatically divide the design domain is developed. The adjacent elements with smaller thickness differences are merged to form TRB subdomains based on the optimization results of forestep, and the TFD method is used again. Finally, TRB finite element modeling codes is developed. According to the second step, modeling of the transition zone is added to finally form the TRB structure that meets the requirements of manufacturing. This method is used to optimize the crashworthiness of the thin-walled tube under axial and oblique loading. Numerical results demonstrate the effectiveness of this method. Therefore, this method can be used to design high-efficiency energy absorber on aircraft or automobile, such as the strut of aircraft and energy absorption box of automobile.
TUG1/MAZ/FTH1 Axis Attenuates the Antiglioma Effect of Dihydroartemisinin by Inhibiting Ferroptosis
Authors: Gong Hailong , Gao Mingjun , Lin Yuancai , Liu Jinliang , Hu Zhiwen , Liu Jing
Published: September 2022

Glioma is the most common primary intracranial malignant tumor in the brain. Currently, due to the limited treatment methods, the clinical outcome of patients with standard surgery combined with radiotherapy and chemotherapy is not satisfactory. Therefore, we urgently need to develop effective drugs to solve this problem. As a semisynthetic derivative of artemisinin, dihydroartemisinin (DHA) has been proved to have antitumor activity in glioma, which can induce apoptosis and inhibit the proliferation, migration, and invasion of glioma cells. In recent years, ferroptosis has been identified as another antitumor mechanism of DHA. Researchers have shown that DHA could promote ferroptosis in glioma cells. However, the specific molecular mechanisms of ferroptosis induced by DHA need more exploration. In this study, we found DHA could induce ferroptosis with ROS production and lipid peroxidation in glioma cells. Low expression of GPX4 and high expression of HMOX1 were identified in DHA treated glioma cells. Surprisingly, we found FTH1, a negative regulator of ferroptosis, upregulated in DHA treated glioma cells. It indicated that there should be some mechanisms that may cause ferroptosis attenuation in DHA treated glioma cells. For the first time, we confirmed that MYC-associated zinc finger protein (MAZ) could actively regulate FTH1 by binding to FTH1 promoter by CHIP assay. MAZ was further identified as the direct target of long noncoding RNA (lncRNA) TUG1 through luciferase assay. Downregulated expression of TUG1 and upregulated expression of MAZ were identified in DHA treated glioma cells. TUG1 overexpression or inhibition of FTH1 expression could enhance the antiglioma effect of DHA in vitro and in vivo, providing a promising strategy to enhance the antitumor effect of DHA in glioma.
Efficacy of COVID-19 Convalescent Plasma Based on Antibody Concentration
Authors: Cain Wesley V , Sill Anne M , Solipuram Vinod , Weiss John J , Miller Carole B , Jelsma Peter F
Published: September 2022

Background. Convalescent plasma obtained from individuals who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains neutralizing antibodies to the virus and has been frequently used as a treatment in hospitalized patients with severe COVID-19. Methods. We conducted a retrospective, observational cohort study involving 96 hospitalized patients with severe COVID-19 who were allocated in a 1 : 1 ratio to having received either high antibody concentration convalescent plasma or low antibody concentration convalescent plasma. Quantitative measurements of IgG to the receptor-binding domain (RBD), the S1 subunit of the spike protein, and the SARS-CoV-2 nucleocapsid (N) protein were determined from donor plasma samples. The primary outcome was all-cause mortality within 30 days following convalescent plasma administration in regard to each of the three antibody domains. Results. Within the nucleocapsid antibody domain, death occurred in 22.2% of patients in the low antibody concentration group versus 23.5% in the high antibody concentration group (

p
=
0.88

). Within the RBD antibody domain, death occurred in 22.9% of patients in both the low and the high antibody concentration groups (

p
=
1.0

). Within the S1 subunit antibody domain, death occurred in 27.1% of patients in the low antibody concentration group versus 18.8% in the high antibody concentration group (

p
=
0.33

). Conclusions. No significant differences were observed between low and high concentration convalescent plasma in regard to overall mortality at 30 days, hospital length of stay, number of ventilator days, and subsequent receipt of invasive mechanical ventilation in patients who were previously not receiving mechanical ventilation. Trial Registration. This study was not associated with a clinical trial due to the retrospective nature of study design.
A Novel Approach Based on Generative Adversarial Network for Signal Enhancement in Wireless Communications
Authors: He Shoushuai , Zhu Lei , Yao Changhua , Wang Lei , Qin Zhen
Published: September 2022

Wireless communication signals are often affected by noise and interference in the channel during transmission, which makes it difficult for the receiver to analyze. The signal enhancement technology can suppress the noise and interference in the signal, so as to improve the communication quality. It is one of the main research directions of signal processing. Classical enhancement methods separate the signals through separable transform domain. Artificial construction of the corresponding separable transform domain requires prior information of noise and interference, but they have the characteristics of randomness. Further, these methods usually use high-level features and rely on statistics, so they can only deal with specific noise conditions. At present, deep learning is increasingly applied in the field of wireless communications due to its powerful feature extraction ability for large sample sets. In this paper, a communication signal enhancement model based on generative adversarial network (GAN) is proposed. Compared with classical methods, the signal is operated directly and the model is trained end-to-end. It can adapt to different noise conditions and avoid the above problems. An independent and invisible test set is used to evaluate several comparative methods. The experimental results confirm the effectiveness of the proposed model.
A Trusted and Privacy-Preserved Dispersed Computing Scheme for the Internet of Mobile Things
Authors: Zhao Yan , Hu Ning , Zhao Yue , Zhang Yuqiang
Published: September 2022

Existing computing paradigms of the Internet of Mobile Things (IoMT) and social networks cannot effectively serve users due to their limited computing ability, dynamic mobile networks, weak connectivity, and high energy consumption and investment costs. Dispersed computing (DCOMP) is a promising way to solve the above issues. However, DCOMP is emergent, and few studies apply DCOMP to IoMT and social networks. Moreover, security problems also arise when introducing DCOMP to IoMT and social networks. In this paper, we propose a novel reference architecture to realize DCOMP in IoMT or social networks. We also propose two models—a trusted application discovery and acquisition model and a security domain-based computing offloading model—to enhance the security of the proposed architecture. The key idea of the first model is to use blockchain to construct a trusted application storage and acquisition system. This system guarantees that the tasks offloaded to dispersed devices are trusted. In the second model, we design two algorithms to offload tasks to appropriate dispersed devices to protect users’ privacy as much as possible. The experimental results prove the effectiveness of the proposed scheme.
Value of Cytokine Expression in Early Diagnosis and Prognosis of Tumor Metastasis
Authors: Li Tingwei , Liu Minling , Dai Huiru , Li Xueying , Liao Jiehao , Zheng Zilong , Pan Yihang , Liu Yuchen , Fang Shuo
Published: September 2022

Objective. To investigate the association of the plasma level of cytokines and blood routine indexes with clinical characteristics in patients with cancer. Methods. We analyzed plasma samples derived from 134 cancer patients. Interleukins (IL) 1β, 2, 4, 5, 6, 8, 10, 12p70, 17, IFN-γ, IFN-α, and TNF-α, and blood routine indexes were measured. The associations of the levels of cytokine and blood routine indexes with demographic and clinical characteristics of cancer patients were analyzed. Partial least-squares discriminant analysis was employed to identify cancer metastasis using these plasma cytokine metrics as input. We compared the predictive effectiveness of numeric machine learning algorithms using these indexes and showed a promising model implemented with random forest. Results. Plasma levels of IL-6 and IL-8 in cancer patients with metastases were higher than those without metastases (

P
<
0.05

). Cancer patients without metastases had significantly higher levels of plasma IL-12p70 and percentage of lymphocytes as compared with those with metastases (

P
<
0.05

). Our random forest model showed the highest prediction performance (upper quantile AUC, 0.885) among the six machine learning algorithms we evaluated. Conclusion. Our findings suggest that plasma levels of IL-6, IL-8, and IL-12p70 and the percentage of lymphocytes could predict the recurrence, metastasis, and progression of cancer. Our findings will provide guidance for tumor monitoring and treatment.
The Knowledge Service Model of Technology-Based SMEs from the Perspective of Value Cocreation
Authors: Sun Dongliang , Yao Wei , Sun Bin
Published: September 2022

China’s economy has shifted from the stage of high-speed growth to the stage of high-quality development, and enterprises are facing increasingly complex conditions in the rapidly changing environment. In the process of transformation from “production value growth” to “value-driven”, knowledge service plays an important role, which can both increase knowledge innovation capability and export heterogeneous knowledge to the outside world. Under such circumstances, it is necessary to focus on cultivating the capability of knowledge services from the perspective of value cocreation. Starting from this concept, the temporal pattern of data is explored in terms of time span; the service mode of knowledge service to its customers is explored in terms of spatial interaction, and the framework of knowledge service is explored in terms of content structure. It is found that (1) there are five knowledge service models for science and technology-based SMEs, and there exists an efficient service combination of “online+offline”; (2) customers can basically be divided into three categories: passive, active, and neglected. (3) The value cocreation path of knowledge services for science and technology-based SMEs is divided into initial stage-interaction stage-implementation stage; “two-way identification”-“joint participation”-“win-win value” knowledge service value cocreation model.
Effect of Quality Control Circle Activity Nursing Combined with Respiratory Function Exercise Nursing on Patients with Esophageal Cancer
Authors: Yu Hairu , Li Sha , Shi Shasha
Published: September 2022

Objective. To explore the effect of quality control circle activity nursing combined with respiratory function exercise nursing on esophageal cancer patients’ immune function and nutritional status. Methods. The clinical case data of 119 esophageal cancer patients admitted to our hospital were selected as the research objects from May 2019 to July 2021. They were divided into the quality control circle activity care group (QCCAC) (9 cases dropped due to incomplete case data, n= 50) and respiratory function exercise care group (10 cases dropped due to incomplete case data, n=50) by the random number table method, the respiratory function exercise care group was treated with respiratory function exercise care, while the QCCAC group was treated with QCCAC. Changes in lung function, immune function, and nutritional status before and after nursing were compared in the two groups of patients. Results. Before nursing, there was no significant difference in pulmonary function indexes, immune function indexes, and the level of nutritional status indicators between the two groups (

P
>
0.05

). After nursing, the finger pulse oxygen saturation, vital capacity (VC), respiratory rate, forced vital capacity (FVC), deep inspiratory volume (IC), and maximum ventilation (MVV) of the QCCAC improved, and the QCCAC group was significantly higher than the respiratory function exercise care group (

P
<
0.05

). After nursing, the QCCAC’s CD3+, CD4+, IgG, IgM, and IgA levels increased, and the QCCAC group was significantly higher than the respiratory function exercise care group. The CD8+ level decreased, and the QCCAC was lower than the respiratory function exercise care group (

P
<
0.05

). After continuous nursing, the QCCAC’s D-lactic acid, DAO, FFMI, Hb, ALB, PA, and other nutritional evaluation indexes all increased, and the QCCAC was significantly higher than the respiratory function exercise care group (

P
<
0.05

). Conclusion. Quality control circle activity nursing combined with respiratory function exercise nursing can effectively improve the immune function, respiratory function, and nutritional status of esophageal cancer patients.