bluuebunny/crossref_metadata_2025 huggingface dataset:
Cancer cervix: Epidemiology and disease burden
Authors: Pimple Sharmila , Mishra Gauravi
Published: March 2022

Cervical cancer remains a major public health problem, ranking as the fourth most common cause of cancer incidence and mortality in women worldwide. Wide variations in cervical cancer incidence and mortality were observed with highest incidence rates in Sub Saharan Africa and with 85% of deaths occurring in developing regions of the world. Non-existent or inadequate screening in public health care settings and limited access to the standard treatment options explains the large geographic variation in cervical cancer rates. Persistent infection with high-risk Human papillomavirus (HPV) types is the major risk factor for cervical cancer. High parity, long-term use of oral contraceptive pills, tobacco consumption, co-infection with other sexually transmitted agents, lifestyle factors such as multiple sexual partners, younger age at first sexual intercourse, immunosuppression, and diet have been identified as the co-factors most likely to influence the risk of acquisition of HPV infection and its further progress to cervical carcinogenesis. Differential screening rates and changes in epidemiological patterns have contributed to decreasing trends in cervical cancer in some developed regions of the world. Lower rates were also observed in North Africa and the Middle East, which may be attributed to cultural norms and conservative sexual behaviors. Across world regions, HPV prevalence was highest in women younger than 35 years of age, declining to a plateau in middle age and showed significant association between national age standardized incidence rates and corresponding estimates of HPV prevalence. The five most common HPV types in HPV-positive women worldwide were HPV16, HPV18, HPV31, HPV58, and HPV52, representing 50% of all HPV infections with HPV-16 and HPV-18 infections accounting for about 70% of the total infection burden. Tracking changing trends in the cervical cancer epidemiological patterns including HPV genotypes will immensely contribute toward effective prevention and control measures for cervical cancer elimination.
The ‘Why and How’ of Cervical Cancers and Genital HPV Infection
Authors: Bhat Dharitri
Published: March 2022

Knowing about the virology of human papillomavirus (HPV) including its structure, functions and mechanism of infection, helps in understanding the disease process and morphology of precancerous lesions for cervical cancer. Two types of HPV, low- and high-risk type, adopt different mechanisms of infection which cannot be differentiated on morphological basis. In addition to HPV infection, many other factors such as genetic predisposition, hormonal factors, host immune response, and multiple sexual partners can modify the course and progression of the disease. The viral genome comprises early and late proteins. These early and late genes are expressed in particular course of time after initial infection. Various products of early genes (E1–E7) coordinate for completion of viral life cycle in maturing squamous epithelium by utilizing replication factors and DNA polymerase enzyme of the host cell nucleus. The late genes are mainly concerned with packaging of the viral particles and their release through mature squamous cells. The episomal form of infection seen in the low-risk group of viruses results in productive infection whereas the integrated form seen in high-risk group of viruses is the basis of disruption of host cell growth cycle by inactivating two important tumor suppressor genes p53 and Rb gene by products of E6 and E7 genes. Cervical precancerous lesions and cancer are the resultant effect of the accumulation of mutations. This article discusses the virology of HPV, pathogenesis of HPV infection, and various other factors modifying the disease course.
Studies on Antioxidants, Antibacterial activities and Phytochemistry of Mimusops elengi. Linn
Authors: Kannan Kilavan Packiam , Mohamed Imdhiyas , Kannadhasan Sabarivasan , Dhaksinamoorthy Madhankumar
Published: March 2022

The present study involves screening of phytoconstituents in the ethanolic extract of Mimusops elengi. L leaves. The total phenolic content, antioxidant and antimicrobial activities of the same were determined. Mimusops elengi. L leaves were extracted with ethanol using Soxhlet apparatus. The total phenolic content was determined by Folin-Ciocalteu method. The antioxidant potential of the extract was evaluated by using 2, 2-diphenyl 1- picryl Hydrazyl radical (DPPH) scavenging assay and ferric reducing power (FRAP) assay. Antibacterial activity was assessed against four MTCC bacterial pathogenic strains by agar well diffusion assay and minimum inhibitory concentration (MIC) assay. Qualitative screening of phytochemicals justifies the presence of Saponins, Terpenoid, Cardiac glycosides, Flavonoids, Phenol, Steroids in ethanolic leaf extract. Total phenolic content was found to be 4.445±2.857 mg TAE/g DW (Dry weight) of leaf extract. Significant amount of DPPH free radical scavenging activity was found in leaf extract (IC50 value=45μg/ml) when compared to the reference butylated hydroxy anisole (BHA) (IC50 value=59.41μg/ml). The plant extract exhibit good ferric ion reducing power but not as effective as standard FeSO4. The plant extract proved the good level of antibacterial activity against 4 test pathogens. Agar-well diffusion assay showed the inhibition zone of 17-24 mm. Minimum inhibitory concentration was found to be 6.25 μg/ml and 12.5 μg/ml against gram positive and gram negative bacteria respectively. This study reveals that Mimusops elengi leaves possess valuable bioactive compounds with potential therapeutic applications.
In vitro regeneration of shoot and roots of the wild folkloric medicinal plant Ammannia baccifera L. via indirect organogenesis from leaf explant cultures
Authors: Kolar Amzad Basha , Sulaiman Sheik Mohamed , Mohamed Hussain Ghouse Basha , Mahaboob Khan Shareef Khan
Published: March 2022

Ammannia baccifera L. is a wetland medicinal herb that belongs to the family Lythraceae. This plant is very notable to have a wide scope in pharmacological, therapeutic and medicinal properties. The current examination imparts an effective, proficient and fast strategy of commercial proliferation to satisfy the folklore medicinal and pharmacological demands of the market. A large-scale micropropagation of Ammannia baccifera L was done through a meticulous and a well-organized procedure. The leaf segments were cultured on MS medium augmented with different concentrations (0.5–2.5 mg/l) of 6- benzylaminopurine (BAP), (0.5- 2.0 mg/l) 1- naphthaleneacetic acid (NAA) and (1.0- 2.0 mg/l) 2,4- Dichlorophenoxyacetic acid (2,4-D) and were used for callus initiation. BAP at 1.0 mg/l combined with 0.5 mg/l NAA was found to be the best concentration and combination for initiation of high frequency of reddish green nodular callus (95.00±1.87) and good response for leaf explants. For shoot regeneration, MS medium blended with BAP at 1.5 mg/l and IAA at 0.6 mg/l produces maximum percentage of shoots from the callus derived by leaf explant. The leaf segments produce maximum percentage shoots (90.00±1.52), total number of shoots per explant (26.33±1.45) and length of shoot (9.63±0.73 cm). However, healthy established shoots were cultured on MS medium fortified with 1.5 mg/l indole-3-butyric acid (IBA) along with 2.0 mg/l. Indole-3-acetic acid (IAA) was found to be best for the root initiation and production in the leaf segments (95±1.57), number of roots (19.33±0.88) and root length (8.63±0.61cm). The regenerated plantlets were relocated to paper cups filled with vermiculite:sand:soil in the proportion of 1:2:1 (w/w) and were then transferred into outdoor conditions.
METHOD OF MONITORING THE OPERATIONAL CHARACTERISTICS OF ENGINE OILS
Authors: Боднарь О.Б. , Анищенко И.В. , Хусаинов Ш.Г. , Дидин Г.А.
Published: March 2022

Представлено экспериментальное и теоретическое обоснование математической модели дисперсионных зависимостей диэлькометрических параметров моторных масел. Разработана методика оценки изменения щелочного числа моторных масел в процессе эксплуатации.

The experimental and theoretical substantiation of the mathematical model of dispersion dependences of dielectric parameters of motor oils is presented. A methodology for estimating changes in the alkali number in the process of operation has been developed. Modeling of the device for controlling dielectric properties was carried out.
PASSERINE BIRDS OF FIR FOREST OF CENTRAL KAMCHATKA
Authors: Герасимов Ю.Н. , Бухалова Р.В. , Гринькова А.С.
Published: March 2022

Состав населения зимующих птиц еловых лесов Камчатки исследован в предзимний периоды 2007–2017 гг. Использован трансектный метод учета птиц, суммарный учетный маршрут составил 528 км. Обобщены данные по численности разных видов. Обсуждается роль ельников как важных мест зимовки птиц. 

Number of wintering birds of are studied in fir forests in late autumn seasons 2007–2017. Data on 528 km transect counts are submitted. Importance of far forests in Central part of Kam-chatka Peninsula for wintering birds is discussed.
THE EQUIPMENT FOR MEASURING THERMAL CHARACTERISTICS OF THE SOLID MATERIALS USING A FLAT PROBE METHOD
Authors: Кириллин А.Р. , Малышев А.В. , Степанов А.А. , Тимофеев А.М.
Published: March 2022

В статье рассматривается применение метода кругового плоского зонда постоянной мощности для определения теплофизических характеристик тел. Приводятся зависимости для расчета теплопроводности и температуропроводности. Описывается измерительная установка, а также приведены результаты эксперимента.

The paper considers the method of a round flat probe of the constant power used to determine the thermal characteristics of the solids. The formulae for the calculation of thermal conductivity and thermal diffusivity are given. The measuring equipment is described and the results of the experiment are presented.
USE OF AVIATION TECHNICAL EQUIPMENT FOR FIRE EXTINGUISHING IN THE KRASNOYARSK TERRITORY
Authors: Акзигитов А.Р. , Майнашева С.О. , Перемышлеников В.В. , Кацура А.В. , Герасимова Д.С.
Published: March 2022

Лесные пожары – одна из наиболее остро стоящих проблем для властей Красноярского края. В данной работе представлена карта пожаров по Красноярскому краю, а также статистика по причинам возникновения пожаров. В работе проведена оценка летно-технических характеристик авиационных технических средств, а также возможность их применение в случае возникновения чрезвычайных ситуации для упрощения процедуры производственного планирования эксплуатации воздушных судов МЧС.

Forest fires are one of the most acute problems for the authorities of the Krasnoyarsk Territory. This article presents the map of fires in the Krasnoyarsk Territory, as well as statistics on the causes of fires. There is assessed the flight performance of aircraft technical equipment, as well as the possibility of their use in case of emergency to simplify the production planning procedures for aircraft operation.
СОПОСТАВИТЕЛЬНЫЙ АНАЛИЗ КОГЕЗИИ В ПОЭЗИИ ЛИ БО И ЕЁ ПЕРЕВОДЕ НА РУССКИЙ ЯЗЫК
Authors: Ли Ч.
Published: March 2022

Статья посвящена особенностям трансляции когезии с китайского языка на русский. Анализ основывается на материале поэзии Ли Бо и её русского перевода. В работе были проанализированы следующие аспекты: 1) дано определение когезии; 2) описаны типы когезии; 3) проведен сопоставительный анализ типов когезии в поэзии Ли Бо на китайском языке и её переводе на русский.
Russian Spiritual Verses in the “Living Book” of the Doukhobors
Authors: Косых А.В.
Published: March 2022

Статья посвящена культовым песнопениям духоборцев — «псалмам», в  которых распеваются тексты русских духовных стихов. Долгое время такие произведения рассматривались музыковедами как образцы, появление которых среди богомолебных песнопений духоборцев напрямую связано с угасанием традиции религиозного пения, выраженным в замещении культовых форм фольклорными. Однако употребление текстов духовных стихов в качестве религиозных (исполняющихся на богомолениях) характерно и для раннего этапа существования духоборчества. Данный факт нашел отражение в многочисленных документах и публикациях XVIII–XXI веков. Первые напевы интересующих нас «псалмов» были зафиксированы в начале ХХ столетия — эпоху, близкую к расцвету религиозно-певческой традиции секты. Проникновение духовных стихов в сферу культовой музыки закономерно для духоборчества. С одной стороны, оно обусловлено связью учения с протестантизмом, с другой — определено принятой в секте устной формой трансмиссии текстов и песнопений, раскрывающих вероучение. При анализе музыкально-стилевых свойств «псалмов» выявляются признаки первоисточников напевов (русских духовных стихов разных историко-стилевых пластов); демонстрируются примеры трансформации фольклорных по стилю песнопений в культовые. В заключение ставится вопрос о жанровой специфике исследованных образцов.

The article is devoted to the cult songs of the Doukhobors — “psalms” chanting the texts of Russian spiritual verses. For a long time, emergence of such samples among the liturgical chants of a sect was considered by musicologists as an indication to a decline in the tradition of religious singing, expressed in the replacement of cult forms with folklore. However, the use of texts of spiritual verses as religious (performed at prayers) is also characteristic of the early stage of development of the Doukhobor sect. This fact is reflected in numerous documents and publications of the XVIII–XXI centuries. The first tunes of the “psalms” of interest were recorded at the beginning of the twentieth century — an era close to the heyday of the religious singing tradition of the sect. Penetration of spiritual verses into cult music is natural for Doukhobors. On the one hand, it is due to a connection of the doctrine with Protestantism, on the other hand, it is determined by the oral form of transmission of texts and chants adopted in the sect. The analysis of the musical and stylistic properties of the “psalms” reveals signs of the primary sources of the tunes (Russian spiritual verses of different historical and stylistic layers). The article also presents examples of the transformation of folklore-style chants into the cult ones, raising in the conclusion a question of genre specificity of the studied samples.
Feodosiy Rubtsov on the Genres of Folk Songs
Authors: Редькова Е.С.
Published: March 2022

В 1960–1970-е годы внимание отечественных исследователей было направлено на решение вопросов, связанных с жанровой спецификой фольклора. В сфере музыкальной фольклористики они приобрели особую актуальность в связи с подготовкой «Свода русского фольклора». Среди публикаций профессора Ленинградской государственной консерватории Феодосия Антоновича Рубцова (1904–1986) отсутствуют научные труды, ориентированные на теоретическое обоснование понятия «жанр» и принципов жанровой классификации. Однако в процессе подготовки изданий народных песен, изучения образно-семантического наполнения напевов и текстов, поиска интонационной общности народных мелодий исследователь обозначил ряд идей, перспективных для дальнейшего развития при анализе жанров. Уточнить представления Рубцова о специфике и границах понятия «жанр» в отношении песенного фольклора стало возможным на основе работы с архивными документами, в частности — стенограммой доклада 1966 года «Принципы определения жанров в народной песенности» из Центрального государственного архива литературы и искусства Санкт-Петербурга. Несколько позже изложенные в сообщении позиции были доработаны, более конкретно определился ракурс наблюдений, который позволил проследить взаимосвязь напева и текста как ключевых для определения жанра народной песни признаков. В результате этой работы Рубцов подготовил и в 1967 году опубликовал статью «Соотношение поэтического и музыкального содержания в народных песнях».

In the 1960s–1970s, the focus of attention of domestic scientists was on the genre specifics of folklore. In the field of musical folklore, the differentiation of genres according to common features was especially relevant for the preparation of the “Collection of Russian Folklore”. In the scientific publications of the Professor of the Leningrad State Conservatory Feodosiy Antonovich Rubtsov (1904–1986) there is no special theoretical explanation of the concept of “genre” and theoretical development of genre classification. However, in the process of preparing editions of folk songs, studying the semantics of tunes and the content of the texts, and searching for the relationship of intonations of folk melodies, the researcher formulated a number of important ideas. Working with archival documents made it possible to clarify Feodosiy Rubtsov’s idea of the concept of “genre”, its boundaries and features. An important document is the transcript of the 1966 report “Principles for Determining Folk Song Genres” from the Central State Archive of Literature and Art of St. Petersburg. Later, Feodosiy Rubtsov developed the ideas presented in the report. His particular interest was connected with the study of the relationship between the tune and the text of a folk song, which is important for determining its genre. As a result, in 1967, Feodosiy Rubtsov published the article “Correlation between Poetic and Musical Content in Folk Songs”.
Determinants of the Saving Behaviour of Saudi Households: An Investigation of Saving Motives and Awareness: العوامل المؤثرة على سلوك الادخار للأسر في المملكة العربية السعودية: دراسة دوافع الادخار والوعي
Authors: Suaad Yahya Sarea, Roaa Osama Badkook Suaad Yahya Sarea, Roaa Osama Badkook
Published: March 2022

This paper aims to investigate the effect of saving motives and awareness on the saving behaviours of Saudi Arabian households. To this end, we collected primary data through a survey of 432 Saudi households. This study considered seven categories of saving motives (emergencies, retirement, children, necessities, home, holidays, and investment) and two measures of saving awareness (concept and importance). The results showed that emergencies, necessities, retirement, and investment were the most potent motives for demonstrating saving behaviours. In addition, there was also evidence that the saving awareness of Saudi households also positively influences their saving behaviours. The findings may inform policy makers and behavioural finance specialists in developing products and services to encourage household saving behaviours and improve saving awareness through financial education.
The impact of the Corona pandemic (Covid- 19) on contracts and financial obligations in Saudi Arabia: أثر جائحة كرونا (كوفيد- 19) على العقود والالتزامات المالية في المملكة العربية السعودية
Authors: Saad Nasser AL.Azzam Saad Nasser AL.Azzam
Published: March 2022

This study aimed to identify the effects of contracts and financial obligations in light of the Covid- 19 pandemic, as one of the contracts most affected by the Covid- 19 epidemic is the financial contracts necessary for both parties, and lax implementation, and the impact may be easy, and it may be such as force majeure and emergency conditions. Which causes fatigue, exhaustion and losses for both parties to the contract, but it is possible to continue implementing the contract if the judge takes his interest, and he can give the obligor a respite if he finds that the emergency circumstance is subject to lapse and termination within a short time that does not harm the obligor to him. The value of the obligation can be adjusted in order to remove the damage and the emergency circumstance, and since the pandemic is one of the force majeure circumstances and the contract cannot continue with it, here the contract is terminated, and the joint wage for work in the custodianship is excluded and did not stipulate the worker’s appointment, so he must take his place if he is unable to work And if there is a delay in the contract due to the pandemic , it is not valid to impose a fine for the delay at that time. The study recommended the need to increase the education and awareness of society, especially traders, brokers, and those engaged in trade, as well as the civil society that contracts with these groups.
Using Metal Substrate to Enhance the Reactivity of Graphene towards Diels-Alder Reactions
Authors: Yang Xiaojian , Chen Feiran , Kim Min , Liu Haitao , Wolf Lawrence , Yan Mingdi
Published: March 2022

The Diels-Alder (DA) reaction, a classic cycloaddition reaction involving a diene and a dienophile to form a cyclohexene, is among the most versatile organic reactions. Theories have predicted thermodynamically unfavorable DA reactions on pristine graphene owing to its low chemical reactivity. We hypothesized that metals like Ni could enhance the reactivity of graphene towards the DA reactions through charge transfer. Results indeed showed that metal substrates enhanced the reactivity of graphene in the DA reactions with a diene, 2,3-dimethoxy butadiene (DMBD), and a dienophile, maleic anhydride (MAH), with the activity enhancement in the order of Ni>Cu, and both are more reactive than graphene supported on silicon wafer. The rate constants were estimated to be twice higher for graphene supported on Ni than on silicon wafer. The computation results support the experimentally obtained rate trend of Ni>Cu>SiO2. This study opens up a new avenue for enhancing the chemical reactivity of pristine graphene through substrate selection.
Testing of Ion Exchange Chromatography Media for Extraterrestrial in situ Sample Preparation on Liquid Samples
Authors: Ferrance Jerome
Published: March 2022

Analysis of liquid samples often includes an initial sample preparation step in which components that are not of interest, or other interfering substances can be removed. Concentration of analytes in a smaller volume is also often important. For samples collected from solar system bodies outside of Earth, it is often not possible to bring the samples back to Earth for analysis, thus the sample preparation method would have to be transported to the liquid sample collection site. The use of ion exchange chromatography as a solid phase extraction method that can be utilized in a remote analysis is investigated in this work. The method developed relied on strong exchangers, with the use of pH changes to elute only analytes while keeping salt ions bound. Method development revealed the need for a pre-elution step in the process to ensure good charge switching of the analytes. Both anion and cation exchange media were evaluated for the capture of analytes from a high salt solution, as would be expected of liquid samples collected on a remote body. Cation exchange media provided the best results, with capture of almost all of the various analytes tested for extraction from simulated ocean water, including amino acids, nucleotides, peptides, and an oligonucleotide. In fact, cation exchange media even captured anionic components such as organic acids, likely through mixed mode hydrophobic based capture. Even though these analytes were released in the wash step, most of the salt removal was completed before release of these analytes, allowing this method to be used for desalting of these analytes. On the other hand, anion exchange media did not capture many of the anionic analytes it was expected to capture when the salt concentration was high. Irradiation exposure, as a model for the solar irradiation expected during deployment of these materials to extraterrestrial locations, did not affect the performance of the ion exchange media tested. Mixed analyte testing showed consistency with individual analyte testing, and coupling of a reverse phase solid phase extraction directly with the ion exchange method was possible.
Sustainable and Scalable Synthesis of Noroxymorphone via a Key Electrochemical N-Demethylation Step
Authors: Sommer Florian , Gerber Aeschbacher Roman , Thurnheer Urs , Kappe C. Oliver , Cantillo David
Published: March 2022

Noroxymorphone is a pivotal intermediate in the synthesis of important opioid antagonists such as naloxone and naltrexone. The preparation of noroxymorphone from thebaine, a naturally occurring opioate isolated from poppy extract, is a multistep sequence in which oxycodone is first generated and then N- and O-demethylated. Both demethylations are problematic from the safety and sustainability viewpoint, as they involve harmful reagents such as alkyl chloroformates or boron tribromide. Herein, we present a green, safe an efficient telescoped process for the N- and O-demethylation of oxycodone. The method is based on the anodic oxidative intramolecular cyclization of the N-methyl tertiary amine with the 14-hydroxyl group of the morphinan, followed by hydrolysis with hydrobromic acid, which releases the carbon from both heteroatoms. The electrolysis process has been transferred to a scalable flow electrolysis cell, significantly improving the reaction throughput and increasing the space-time yield over 300-fold with respect to batch. The sustainability of the new methodology has been assessed by means of green metrics and qualitative indicators. The sustainability assessment has demonstrated that the new methodology is far superior to the conventional chloroformate process
Point-of-care SARS-CoV-2 sensing using lens-free imaging and a deep learning-assisted quantitative agglutination assay
Authors: Potter Colin , Hu Yanmei , Xiong Zhen , Wang Jun , McLeod Euan
Published: March 2022

The persistence of the global pandemic caused by SARS-CoV-2 virus has continued to emphasize the need for point-of-care (POC) diagnostic tests for viral diagnosis. The most widely used tests, lateral flow assays used in rapid antigen tests, and reverse-transcriptase real-time polymerase chain reaction (RT-PCR), have been instrumental in mitigating the impact of new waves of the pandemic, but fail to provide both sensitive and rapid readout to patients. Here, we present a portable lens-free imaging system coupled with a particle agglutination assay as a novel biosensor for SARS-CoV-2. This sensor images and quantifies microbead agglutination through a combination of computational imaging and deep learning as a way to detect levels of SARS-CoV-2 in a complex sample. SARS-CoV-2 pseudovirus in solution is incubated with acetyl cholinesterase 2 (ACE2)-functionalized microbeads then loaded into an inexpensive imaging chip. The sample is imaged in a portable in-line lens-free holographic microscope and an image is reconstructed from a pixel superresolved hologram. Images are analyzed by a deep-learning algorithm that distinguishes microbead agglutination from cell debris and viral particle aggregates, and agglutination is quantified based on the network output. This sensor spans two SARS-CoV-2 viral load concentration ranges: 4.7x10^3-1.5x10^5 copies/ml and high levels > 1.5x10^6 copies/ml. With an additional sensing step, the intermediate range could also be covered by the sensor. This biosensor can be used for fast SARS-CoV-2 diagnosis in low-resource POC settings and has the potential to mitigate the spread of future waves of the pandemic.
The Kasi Learning System – Providing Blind and Low Vision Students Independence in Studying Diagrams
Authors: Wegwerth Sarah , Manchester Gianna , Winter Julia
Published: March 2022

Usable accommodations for students who rely on senses other than vision have not kept pace with the rapid evolution of educational materials to digital format. This trend poses the risk of deselecting Blind and Low Vision (BLV) students from studying fields, such as chemistry, that rely heavily on the use of visuals for communication of ideas and concepts. Practices of adding in accessibility afterwards, by either the producer or school support staff, are generally resource intensive, often do not provide a comparable experience, and are not amenable to dynamic interactive visuals. The Kasi Learning System was built with accessibility at the forefront to provide equitable experiences to students regardless of their visual level. Kasi combines digital interactives with tactile manipulatives and audio-based Augmented Reality to provide a multisensory learning experience. Reported are the design principles and findings from a usability and feasibility study of a prototype of Kasi with ten BLV high school students. Findings from the study indicate that students who used Kasi felt more independent and able to study chemistry. The study also revealed that students who do not regularly rely on their auditory channel for accessing information took longer to become proficient with using the system.
Identification of histone peptide binding specificity and small molecule ligands for the bromodomains of TRIM33α and TRIM33β
Authors: Sekirnik Angelina , Reynolds Jessica , See Larissa , Bluck Joseph , Scorah Amy , Tallant Cynthia , Lee Bernadette , Leszczynska Katarzyna , Grimley Rachel , Storer Ian , Malattia Marta , Crespillo Sara , Caria Sofia , Duclos Stephanie , Hammond Ester , Knapp Stefan , Morris Garrett , Duarte Fernanda , Biggin Philip , Conway Stuart
Published: March 2022

TRIM33 is a member of the tripartite motif (TRIM) family of proteins, some of which possess E3 ligase activity and are involved in the ubiquitin-dependent degradation of proteins. Four of the TRIM family proteins, TRIM24 (TIF1α), TRIM28 (TIF1β), TRIM33 (TIF1γ) and TRIM66, contain C-terminal plant homeodomain (PHD) and bromodomain (BRD) modules, which bind to methylated lysine (KMen) and acetylated lysine (KAc), respectively. Here we investigate the differences between the two isoforms of TRIM33, TRIM33α and TRIM33β using structural and biophysical approaches. We show that the N1039 residue, which is equivalent to N140 in BRD4(1) and which is conserved in most BRDs, has a different orientation in each isoform. In TRIM33β this residue coordinates KAc, but this is not the case in TRIM33α. Despite these differences, both isoforms show similar affinities for H31-27K18Ac, and bind preferentially to H31-27K9Me3K18Ac. We used this information to develop an AlphaScreen assay, with which we have identified four new ligands for the TRIM33 PHD-BRD cassette. These findings provide fundamental new information regarding which histone marks are recognized by both isoforms of TRIM33, and suggest starting points for the development of chemical probes to investigate the cellular function of TRIM33.
Emotion Twenty Questions in Chinese
Authors: Kong Shanshan , Kazemzadeh Abe
Published: March 2022

Our study introduces the emotion twenty questions (EMO20Q) game, an experiment into the cognition and expression of emotions in ordinary people who speak Chinese. The preliminary results show that such a game is felicitous and that the questions generated to describe emotions have commonalities with earlier studies conducted in English.
P’awaq Yupana – Neoábaco de lógica híbrida
Authors: Saldívar Carlos
Published: March 2022

El P’awaq Yupana es una herramienta lúdico-pedagógica desarrollada para facilitar la abstracción de la operación en base binaria en el uso de la yupana inca mediante el método Tawa Pukllay. Sirve, además, para potenciar el pensamiento computacional, permitiendo al usuario encontrar soluciones aritméticas mediante una lógica híbrida de tres tipos de razonamiento aritmético: el andino (reconocimiento de patrones), el indo-arábigo (cálculo mental numérico) y el chino-japonés (manejo de cuentas en herramientas de conteo “ábaco” como apoyo al cálculo mental).
Aplicaciones de blockchain en IoT y computación en la niebla
Authors: Caminero María Blanca , Núñez-Gómez Carlos , Carrión Carmen
Published: March 2022

Desde su concepción en el 2008, la tecnología blockchain ha causado un gran interés en los últimos años. La aplicación inicial fue en el ámbito de las criptomonedas, dando soporte a Bitcoin. Este hecho ya de por sí supuso una revolución en el ámbito de la economía, pues la tecnología hacía posible prescindir de intermediarios (es decir, bancos y entidades financieras) en las transacciones económicas, ahorrando costes y evitando un control centralizado de la información registrada en la blockchain. Más adelante, la tecnología ha evolucionadopara incluir sobre ella la posibilidad de registrar lógica de negocio (es decir, código informático) en la propia blockchain a través de los contratos inteligentes. Esto, junto con el desarrollo de plataformas que permiten implementar blockchains con acceso controlado, ha abierto la puerta a un sinfín de aplicaciones más allá de las criptomonedas. Por otro lado, el concepto de internet de las cosas (IoT, en inglés), donde objetos cotidianos se conectan a internet, generando cantidades ingentes de datos que procesar (usualmente en lo que se conoce como computación en la niebla), es un campo de investigación e innovación que también ha generado gran interés de la industria y la academia en los últimos años. Las tecnologías IoT suponen un complemento perfecto para dotar de conexión con el mundo real a la información almacenada en la blockchain. En este trabajo realizaremos una breve introducción a blockchain y al internet de las cosas y revisaremos algunas aplicaciones que combinan ambas temáticas. Finalizaremos con una pequeña introducción a la línea de investigación sobre blockchain en entornos IoT que llevamos a cabo en el Instituto de Investigación en Informática de Albacete (I3A) de la Universidad de Castilla-La Mancha.
Análisis comparativo de métodos de machine learning para clasificar opiniones sobre el servicio de restaurantes peruanos en Facebook
Authors: Adrianzén Torres Martín Jesús , Escobedo Cárdenas Edwin Jhonatan
Published: March 2022

Las opiniones de los clientes sobre servicios en redes sociales son vitales para las empresas debido a que se pueden utilizar para mejorar y potenciar las oportunidades de negocio si los comentarios pueden analizarse a tiempo. El propósito de este trabajo es determinar los métodos de machine learning con mejor rendimiento para aplicar análisis de sentimientos y clasificar comentarios positivos y negativos sobre el servicio de restaurantes peruanos en Facebook. Como primera contribución en este proyecto, se crearon dos datasets de comentarios de publicaciones de cadenas de restaurantes peruanos en Facebook. La segunda contribución es la metodología propuesta dividida en dos etapas: en la primera etapa se aplicaron técnicas de Lenguaje Natural para el preprocesamiento de los comentarios; en la segunda etapa se analizó el desempeño de los algoritmos de Naive Bayes, Random Forest y SVM con núcleos RBF y Lineal para clasificar las opiniones en los datasets. Los resultados experimentales demostraron que el clasificador SVM obtuvo el mejor desempeño tanto en la etapa de entrenamiento como en la de pruebas con un 91.44% y 94% de exactitud para los datasets primario y secundario respectivamente, probando la viabilidad de la metodología propuesta.
Identificación de expertos como fuente de conocimiento en las organizaciones
Authors: Aures García Alvaro Antonio , Balvín Landeo Adelaida Estela
Published: March 2022

El artículo contextualiza la identificación de expertos en las organizaciones que gestionan proyectos de envergaduras notables en su sector, por medio del mapeo de los coeficientes de competencias que se encuentran circunscritos, en primera instancia, a su trayectoria profesional y seguidamente al dominio avanzado sobre una temática en particular que haya tenido el reconocimiento por sus pares. A efectos de asociarlo a un entorno de demanda de conocimientos específicos, con profesionales altamente activos y motivados por aprender y solucionar problemas, que confluyen en una comunidad de aprendizaje sostenible. La investigación expuesta en el artículo hace referencia a una propuesta metodológica de identificación de expertos basada en la literatura que involucra un conjunto de conceptos de la gestión del conocimiento en el marco de trabajo de las organizaciones, enfatizando especialmente en la identificación y valorización del conocimiento experto para mejorar la competitividad de los equipos de proyectos y facilitar la innovación en entornos altamente colaborativos. Tomando como referencia lo señalado, el estudio evaluó a un conjunto de profesionales directos y coordinadores de proyectos que laboran en diversas instituciones.
Modelo de reconocimiento de variables que influyen en el rendimiento de transacciones de RDBMS aplicando PCA y PCR
Authors: Ponce Vergara José Luis
Published: March 2022

El conocimiento de los factores que influencian la eficiencia de un sistema es importante para su correcta administración y mantenimiento. Múltiples organizaciones soportan sus operaciones con aplicaciones que interactúan con un sistema de gestión de bases de datos relacional (RDBMS), las cuales pueden mejorar su eficiencia a través del conocimiento de los factores que influyen en el rendimiento de las ejecuciones de las sentencias SQL que conforman sus cargas de trabajo, especialmente las cargas de trabajo generadas por aplicaciones implementadas en ambientes de producción que manifiestan recurrencia en el tiempo. El artículo de investigación que se presenta propone un modelo de reconocimiento de factores que afectan el rendimiento de las ejecuciones de las sentencias SQL que se procesan en un RDBMS y discute la implementación de una técnica de predicción de métrica de rendimiento, valiéndose de los algoritmos de aprendizaje de máquina estadístico denominados Análisis de Componentes Principales (PCA) y Regresión de Componentes Principales (PCR), que explotan la información de los planes, estadísticas y métricas generadas durante el ciclo de vida de las ejecuciones de las sentencias SQL.
Aplicación de aprendizaje por refuerzo para el estacionamiento automático de un automóvil en un ambiente simulado
Authors: Inocente Cornejo Marcelo José
Published: March 2022

En el presente trabajo se propone una solución de aprendizaje por refuerzo para efectuar el estacionamiento perpendicular automático en un vehículo de cuatro ruedas. Se centra en diseñar una función de recompensas que es usada para entrenar a los algoritmos Proximal Policy Optimization y Soft Actor Critic, además de la combinación de ambos en un ensamble. Finalmente, se logra obtener un éxito cercano al 99 % y una desviación final de aproximadamente un grado. Al entrenar los algoritmos con posiciones iniciales aleatorias se obtiene un desempeño pobre.
On the concept of solutions for fuzzy fractional initial value problem
Authors: Arpit Dwivedi  , Gunjan Rani  , Jaydev Dabas  , Ganga Ram Gautam
Published: March 2022

It is evident that fuzzy arithmetic is different than that of normal arithmetic due to the different classes of functions and symbols. This article is concerned with an appropriate definition of the fractional derivative and integral in a fuzzy sense and a new concept of solutions for a fuzzy Caputo fractional initial value problem (IVP) is presented. Further, under some sufficient conditions on IVP, the existence, uniqueness, and stability results of the solution are established by applying the iterate methods. For the validation of established results, a particular fuzzy fractional Riccati differential equation is presented.
Penguatan dan pemberdayaan kader sebaya reproduksi sehat remaja sekolah di wilayah Puskesmas Kendal 1 Kabupaten Kendal
Authors: Rejeki Sri , Machmudah Machmudah , Khayati Nikmatul , Khoiriyah Khoiriyah , Alfiyanti Dera
Published: March 2022

Masalah yang dihadapi oleh remaja terjadi pada area kesehatan reproduksi. Masalah tersebut adalah rendahnya pengetahuan remaja tentang kesehatan reproduksi. Sudah banyak pihak yang berupaya untuk menangani permasalahan remaja, namun penanganannya tidak secara komprehensif dan bersifat terfragmentasi juga persial. Sehingga penanganan tersebut tidak optimal. Kegiatan pengabdian ini secara umum bertujuan untuk meningkatkan remaja tentang reproduksi yang sehat bagi remaja.Kegiatan yang dilakukan meliputi pengkajian, seminar kesehatan reproduksi remaja, rekrutmen dan pelatihan kader kesehatan remaja, pembentukan posbindu reemaja, pembinaan posbindu remaja, serta melakukan kerjasama lintas sektor terkait pelaksanaan posbindu remaja Evaluasi program terselenggaranya seminar kesehatan yang dihadiri 100 remaja,
The Political Role of Koya Women in 1958-1991
Authors: Tawfeeq Hawrin Ali , Taib Jamal Fathullah
Published: March 2022

Throughout history, women had crucial role in all aspects of community, this is also true for Kurdish women and women from Koya. In political arena, Women, alongside men, struggled towards the national causes. They endured many sacrifices. However, due to patriarchy system of Kurdish society, women were not offered similar opportunities as men, therefore, their chances for success was limited and they indirectly prevented form proving their themselves. Despite that, women from Koya somehow overcame the obstacles and participated and contributed to the society actively.

It is undeniable the public policy of subsequent ruling governments in Iraq did not pave the way from the active participation of women and neither provided equal opportunities for men and women. For instance, in 1963, when Ba’th regime took control of Iraq in a coup, they attacked Kurdistan region and Koya. They practiced the almost brutality against people, among the early victims were women. As the reaction, and reaction to other barbaric practices of Ba’th regime, Women from Koya participated in armed conflicts in Kurdish liberation movements.

The current research consists of two parts; in introduction, a brief historical survey about the participation and contribution of women from Koya pre1958 revolution is provided. The first part is dedicated to the contribution and activities of women between  19581975. The second part is dedicated to discussing the role of women in political activism and secret organization.
The Situation of Educational system in Pshdar(1958 _ 1989) (Historical Research)
Authors: Kaka Amin Dara Tawfeeq , Ahmad Rasul Mohammad
Published: March 2022

One of the most important reasons for communities developing is the educational system. It has a direct impact on all other aspects of life, which is why it is so important for advanced communities, because success in education leads to success in other aspects of living.

     Pzhadar is an isolated location. It is in the region's order. Many of it residents were illiterate due to the lack of schools in the area, with the exception of few religious educational systems that were served at random. However, after the revolution of July 14, 1958, which changed the country's political system from a monarchy to a republic, education progressed, while much religious schooling was stopped.

 

     Pshdar was always an excellent place for partisans. As a result, all Iraqi governments have been an obstacle to the growth of the educational field. Furthermore, until 1989, the sector was growing year after year.

   This development reduced the number of uneducated people. This progress caused the community to take a step ahead, eliminating the regress of previous years. Even the girls went to schools and stepped into a new world, and as a result, many scholarly and educated people grew up in the area.
THE RELATIONSHIP BETWEEN THE PROCESSES OF SELF-ORGANIZATION AND ORGANIZATION IN SOLVING THE PROBLEMS OF A CHILD AT RISK
Authors: A.D. Abashina , Y.V. Egorova
Published: March 2022

The high pace of development of modern society is accompanied by the dynamic changeability of social problems associated with the processes of socialization of the modern child, there is a tendency to narrow the space of targeted socialization and expand the space of socialization of spontaneous, rapid emergence of a "new" in the social situation of the development of the child. Under these conditions, technologies of socio-pedagogical activity developed to solve problems associated with targeted socialization do not give the necessary result when addressing the problems of socialization of spontaneous.
Research objective: finding a link between the pedagogical processes of organization and self-organization, focused on solving problems arising in the space of spontaneous socialization and related to violations in the field of the value orientation of a child at risk in line with a synergistic (post-classical) approach.
The article presents various aspects of the relationship between organization and self-organization in socio-pedagogical activity. They show that with all the transformations of society affecting the family and school, the personal pillars of the child's socialization are: family as a value, relationships with peers as a value, interesting activities as a value. The interrelation of the processes of organization and self-organization in solving the problems of a child at risk reveals how the well-being experienced by a child, for example, in relationships with classmates, affects the laying of their own socialization trajectories through the self-organization of their personal resources. The interrelationships of these pedagogical processes deepen the understanding of those cases or events that encourage, motivate the child to choose his further path. The main thing in this situation is the experience of the situation as capable or unable to meet the needs of a child at risk in a confidential contact.
CURRENT EXISTENTIAL PROBLEMS IN THE CONTEXT OF SUBJECTIVE-PERSONAL RELATIONSHIPS OF FUTURE SPECIALISTS IN HELPING PROFESSIONS
Authors: E.P. Korablina , S.B. Pashkin , E.I. Brazhnik , N.B. Lisovskaya , P.D. Abramova
Published: March 2022

The growing influence of existential approaches is one of the recognized trends in the development of psychology in the first decade of the 21st century. Existential, "philosophical" questions of human existence are increasingly facing a person today, which to a large extent is a consequence of changes in the social context of human life. The purpose of this study was to identify and analyze actual existential problems in the context of the subjective-personal relationships of future helping specialists. The study involved students of the Institute of Psychology of the Russian State Pedagogical University named after V.I. A.I. Herzen (St. Petersburg), 34 people from the Institute of Pedagogy of the Russian State Pedagogical University named after A.I. Herzen (St. Petersburg) in the amount of 32 people, the average age is 20 years. The study used: the methodology "Relevance of existential problems", modified projective technique of Sachs-Levy "Incomplete sentences"; phenomenological interview (Korablina E.P.). To process the data obtained in the study, the following methods were used: descriptive statistics, comparative statistics (nonparametric Mann-Whitney test). Mathematical data processing was carried out using the Statistics package (SPSS Statistics 17.0). The results of studying the relevance of existential problems have shown that the most pronounced existential problem for both groups is "The meaning of existence." As a result of the analysis of subjective-personal relations, it was revealed that the attitude to life among students-social workers is more traditional than students-psychologists. Phenomenological analysis of students' statements made it possible to determine two types of experiences when establishing semantic meanings and reflecting them in consciousness in the form of images of the profession and oneself in it and in life: the "cognitive-changing type" characteristic of psychology students and the "cognitive-accepting type" characteristic of social worker students.