bluuebunny/crossref_metadata_2025 huggingface dataset:
Optical monitoring of glutamate release at multiple synapses in situ detects changes following LTP induction
Authors: Kopach Olga , Zheng Kaiyu , Rusakov Dmitri
Published: December 2019

Information processing and memory formation in the brain relies on release of the main excitatory neurotransmitter glutamate from presynaptic axonal specialisations. The classical Hebbian paradigm of synaptic memory, long-term potentiation (LTP) of transmission, has been widely associated with an increase in the postsynaptic receptor current. Whether and to what degree LTP induction also enhances presynaptic glutamate release has been the subject of debate. Here, we took advantage of the recently developed genetically encoded optical sensors of glutamate (iGluSnFr) to monitor its release at CA3-CA1 synapses in acute hippocampal slices, before and after the induction of LTP. We attempted to trace release events at multiple synapses simultaneously, by using two-photon excitation imaging in fast frame-scanning mode. We thus detected a significant increase in the average glutamate signal during potentiation, which lasted for up to 90 min.
Tumor microenvironment characterization and Immune infiltration in head and neck squamous cell carcinoma
Authors: wu zenghong , niu xun , Xiao Xi-Yue , chen xiong
Published: December 2019

Objection: Head and neck squamous cell carcinoma (HNSCC), a basic malignant tumor of the head and neck distinct. As a famous heterogeneous disease, the jobs of immune cells inside the tumor-related as yet missing for HNSCC, particularly in current immunotherapy. Method: We explored the TME, TMB and evaluate the 22 TIICs subsets of immune response based on GEO and TCGA database of HNSCC to explore its relationship with atomic subpopulation, survival, function and expression difference and reveal potential targets and biomarkers for immunotherapy. Results: Observing the download of GSE6631 database contained 22 HNSCC samples and 22 normal samples and TCGA database contained 111 HNSCC and 12 normal tissues. The results suggested that the expression of macrophages M0 and T cells CD4 memory resting was significant difference and may plays an important role in regulate cancer progression (P<0.05). The result of tumor mutational burden revealed that the most common somatic mutations variant classification was missense mutation, the most common DNA sequence polymorphism type was SNP, the most common single nucleotide variants (SNV) class was C>T, the variants per sample median was 78 in HNSCC patients. Top 10 mutated genes that related to TMB was TP53, TTN, FAT1, MUC16, CDKN2A, CSMD3, SYNE1, LRP1B, NOTCH1 and PIK3CA. We portrayed the immune scene in detail, uncovering the awesome immune infiltration styles of various subtypes in HNSCC. Conclusion: The intricate connection between TIIC, TMB and genomic alterations was additionally set up. Our paintings advance the information of immune response and offers significant assets for research to enhance immunotherapy.
An analysis of infections incidence of multiple human papillomavirus (HPV) rising in cervical and genital samples
Authors: Hu Wen , Liu Xin-mei , Guan Meng-meng , Zhang De-zhi , Kang Xiao-jing
Published: December 2019

Background : Human papillomavirus (HPV) is associated with cervical cancer and genital condyloma, which is mainly transmitted through sexual contact.Cervical HPV infection in females and genital HPV infection in males can induce epithelial proliferation on both mucosal and cutaneous surfaces. HPV is divided into high-risk (HR) and low-risk (LR) types according to their oncogenic potential. The HR geneotypes are considered as etiological factors for invasive cervical cancer in females, and the LR geneotypes are correlated with hyperplastic lesions, including external genital warts, condyloma acuminata, and so on. The aim of this study was to investigate the prevalence of HPV infection and geneotype distribution among individuals in Xinjiang Province.Methods A total of 1094 patients the etiology and species with characteristic of cervical and genital warty surface which mainly come from CA in dermatology and STD outpatient service of People's Hospital of Xinjiang Uygur Autonomous Region.Using a method of real-time fluorescence quantitative PCR for the detection of human papilloma virus HPV 23 typing.Results The prevalence of HPV infection was 67.46%, the most common LR-HPV subtypes were HPV-6 (16.27%), HPV-11 (4.57%), HPV-42(1.19%) and HPV-43(1.19%), and HR-HPV subtypes were HPV-16 (1.65%) and HPV-58(0.91%). The prevalence of HPV infection with single subtype and multiple subtypes was 32.91% and 34.55%, respectively. Among the females infected with a single HPV subtype, 26.11% were infected with a HR-HPV subtype. Among the females infected with multiple HPV subtypes, 18.52% were infected with multiple HR-HR HPV subtypes. The prevalence and subtype distribution of HPV infection showedage differences ( P =0.012), and the prevalence peak of HPV infection was observed in females aged 20-29 years (292/404, 72.28%).Conclusion The prevalence of multiple infection was higher than singleinfection, and the prevalence varied significantly with age while had little association with race and gender.
Midbrain/pons area ratio and clinical features predict the prognosis of Progressive Supranuclear Palsy
Authors: cui shishuang , ling huawei , du juanjuan , lin yiqi , pan jing , zhou haiyan , wang gang , wang ying , xiao qin , liu jun , tan yuyan , chen shengdi
Published: December 2019

Introduction: Progressive Supranuclear Palsy (PSP) is a rare movement disorder with poor prognosis. The natural history of PSP has been described in a few studies. This retrospective study aims to characterize the natural history of PSP and to find predictors of shorter survival and faster decline of activity of daily living.Method: All patients recruited fulfilled the movement disorder society (MDS) clinical diagnostic criteria for PSP (MDS-PSP criteria) for probable and possible PSP with median 12 years. Data were obtained including age, gender, date of onset, age at onset (AAO), symptoms reported at first visit and follow-up, date of death and date of institutionalization. Magnetic resonance imaging was collected at the first visit. Endpoints were death and institutionalization. K-M method and Cox proportional hazard model were used to explore factors associated with early death and institutionalization.Results: 59 patients fulfilled MDS-PSP criteria were enrolled in our study. 19 patients (32.2%) had died and 31 patients (52.5%) had institutionalized by the end of the follow-up. Predictors associated with poorer survival were late-onset PSP and decreased M/P area ratio. Predictors associated with earlier institutionalization were older AAO and decreased M/P area ratio.Conclusion: Older AAO and decreased M/P area ratio were predictors for earlier dearth and institutionalization in PSP. The neuroimaging biomarker M/P area ratio was a predictor for prognosis in PSP.
Study on the purification effect of a pediatric isolation bed on the air in general hospital wards
Authors: Liu Tiantian , Wang Mei , Hao Xiaotang , Guo Yubing , Zhou Rong
Published: December 2019

Background: Patients with acute infectious respiratory illness may emit bio-aerosols containing pathogens capable of infecting susceptible hosts, including other patients and healthcare workers. This study aimed to evaluate the purification effect of a pediatric isolation bed on aerosols and microorganisms in the air in experiment rooms and verify the purification efficiency in general wards. Methods: Experiments were carried out in two settings: one with isolation bed and the other with regular bed. Using a dust particle counter to discriminate particles sizes in the air and using Anderson’s six levels to discriminate S. albicans, the purification rate in the two rooms was evaluated. The concentration of cigarette particles(size 0.3–0.5 μm,0.5-1.0μm ) and S. albicans in the air was significantly decreased in the experimental room, indicating that the air was purified. Then detection the aerosol in the room to vilidaty the purification rate.Finally detection of aerosol and sedimentation bacteria in the air of general wards. Results: Isolation beds in demonstration ward have a purifying effect on both aerosols and sedimentation bacteria. Conclusions:Isolation bed can therefore be used in hospitals to reduce the risk of nosocomial infection and protect the health of doctors, patients, and visiting relatives.
Umbilical cord blood vitamin A levels in relation to the outcome of late-preterm infant: A prospective study
Authors: Tao En-Fu , Chen Cai-E , Chen Yun-Qin , Cai Lin-Yan , Yuan Tian-Ming
Published: December 2019

Background: Low Vitamin A levels of plasma increase the risk of neonates’ morbidity. However, whether umbilical cord blood (UCB) vitamin A levels have an association with the outcomes of late-preterm infants (LPI) is not well established. This study aimed to determine umbilical cord blood vitamin A levels and their correlation with outcomes of late-preterm infants. Methods: We prospectively studied 208 LPI between January 1, 2014，and June 30, 2015. The specimens of UCB were collected shortly after birth, and vitamin A levels were determined by Enzyme-Linked Immunosorbent Assay. All singleton newborns, with 34+0 weeks to 36+6 weeks’ gestational age, were eligible for study inclusion in the studied time intervals. Exclusion criteria included significant congenital malformations or chromosomal abnormality or congenital metabolic disease, or life-threatening disease. All subjects were implemented to follow up, and jaundice, sepsis, respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, death, etc. were recorded. Results: The prevalence of low UCB vitamin A level <0.7 μmol/L was 37.5% in LPI. UCB vitamin A levels of LPI with cesarean section was lower than that with vaginal delivery (0.734 (0.634-0.796) μmol/L VS 0.904 (0.666-1.100) μmol/L P = 0.001). Additionally, binary logistic regression analysis revealed that the cesarean section was an independent risk factor for UCB vitamin A level < 0.7 μmol/L. However, UCB vitamin A levels did not correlate with gestational age, birth weight, and sex. Neonates with hospitalization or oxygen supplementation or RDS group had significantly lower UCB vitamin A levels than their counterparties ( P < 0.05), other than with hyperbilirubinemia or sepsis ( P > 0.05). However, univariate binary logistics regression analysis suggested that UCB vitamin A level < 0.7 μmol/L was not an independent risk factor for hospitalization, oxygen therapy, hyperbilirubinemia, sepsis and RDS. Conclusions: Low umbilical cord blood vitamin A levels are common among late-preterm infants. Delivery with cesarean section is an independent risk factor for low umbilical cord blood vitamin A level. However, there is no evidence that low vitamin A level is associated with morbidity of late-preterm infants, including hyperbilirubinemia, sepsis and respiratory distress syndrome.
Health-related quality of life (FACT-GP) in Sweden
Authors: Bagge Ann-Sophie Lindqvist , Carlander Anders , Fahlke Claudia , Bagge Roger Olofsson
Published: December 2019

Background: Though many studies have used disease-specific instruments, such as the Functional Assessment of Cancer Therapy (FACT), when studying health-related quality of life (HRQOL) in patients, few studies have described normative HRQOL values in the general population using FACT - General Population (FACT-GP). The general aim of the present study is to describe the normative HRQOL values in the general Swedish population by using the FACT-GP instrument and investigate to what degree sociodemographic factors and status of self-rated health (SRH) correlates with HRQOL. Methods: The participants consisted of a pre-stratified (gender, age and education) sample of Swedish citizens that previously had enrolled to be a part of a web panel hosted by a research institute (SOM Institute) at the University of Gothenburg in Sweden. The HRQOL was assessed by using the FACT-GP and self-rated health status (SRH). Results: A higher FACT-GP score was mainly associated with males, higher age, higher income and better SRH. The results showed that the Swedish sample scored lower on FACT-GP than previous studies. Conclusions: Since HRQOL is frequently used as an important endpoint in healthcare research, there is an increasing need for normative data. The results from this study serve as a general population standard to which other studied HRQOL-data could be given meaning.
Interpretation and content validity of the items of the numeric rating version Short-WORC to evaluate outcomes in management of rotator cuff pathology: A cognitive interview approach.
Authors: Furtado Rochelle , MacDermid Joy C , Bryant Dianne , Faber Kenneth J , Athwal George S
Published: December 2019

Background: The shortened version of the Western Ontario Rotator Cuff Index (Short-WORC) is a patient reported outcome measure that evaluates quality of life (QoL) of patients with rotator cuff pathology. However, formal content validation of the full or Short-WORC has not been reported. This study aims to understand how 1) people interpret and calibrate responses to items on the Short-WORC and 2) compensatory strategies that might enhance function and thereby affect responses.

Methods: This study uses cognitive interviewing, a qualitative methodology that focuses on the interpretation of questionnaire items. Patients with rotator cuff disorders (n=10), clinicians (n=6) and measurement researchers (n=10) were interviewed using a talk aloud structured interview that evaluated each of the 7 items of the Short-WORC. All interviews were recorded and transcribed verbatim by one researcher (R.F). Analysis was done through an open coding scheme using a previously established framework.

Results: Overall, the items on the Short-WORC were well received by participants. Through the interviews, the 6 themes of: Comprehension, Inadequate response definition, Reference Point, Relevance, Perspective Modifiers and Calibration Across Items emerged. The items of working above the shoulder (90%), compensating with the unaffected arm (88%) and lifting heavy objects (92%) were the most relevant to participants. Participants calibrated their scores on the items of sleeping and styling (19%) the most. Perspective modifiers of gender, influenced the calibrations of items of styling your hair (30%) and dressing or undressing (19%). Compensatory strategies of task-re allocation and using assistive devices/resources were frequently mentioned by participants. Overall, participants had minor comprehension issues, but found the 7- items of the Short-WORC to be relevant to QoL.

Conclusions: Therefore, the findings demonstrate that the Short-WORC is not cognitively complex, but varies with patient perspectives. Overall, the Short-WORC provides evidence of demonstrating strong content validity when used for rotator cuff disorder patients.
Measurement properties of the Musculoskeletal Health Questionnaire (MSK-HQ): a between country comparison
Authors: Christiansen David Høyrup , McCray Gareth , Winding Trine Nøhr , Andersen Johan Hviid , Nielsen Kent Jacob , Karstens Sven , Hill Jonathan C
Published: December 2019

Background The Musculoskeletal Health Questionnaire (MSK-HQ) has been developed to measure musculoskeletal health status across musculoskeletal conditions and settings. However, the MSK-HQ needs to be further evaluated across settings and different languages. Objective The objective of the study was to evaluate and compare measurement properties of the MSK-HQ across Danish (DK) and English (UK) cohorts of patients from primary care physiotherapy services with musculoskeletal pain. Methods MSK-HQ was translated into Danish according to international guidelines. Measurement invariance was assessed by differential item functioning (DIF) analyses. Test-retest reliability, measurement error, responsiveness and minimal clinically important change (MCIC) were evaluated and compared between DK (n=153) and UK (n=166) cohorts. Results The Danish version demonstrated acceptable face and construct validity. Out of the 14 MSK-HQ items, three items showed DIF for language (pain/stiffness at night, understanding condition and confidence in managing symptoms) and three items showed DIF for pain location (walking, washing/dressing and physical activity levels). Intraclass Correlation Coefficients for test-retest were 0.86 (95% CI 0.81 to 0.91) for DK cohort and 0.77 (95% CI 0.49 to 0.90) for the UK cohort. The systematic measurement error was 1.6 and 3.9 points for the DK and UK cohorts respectively, with random measurement error being 8.6 and 9.9 points. Receiver operating characteristic (ROC) curves of the change scores against patients’ own judgment at 3 months exceeded 0.70 in both cohorts. Absolute and relative MCIC estimates were 8-10 points and 26% for the DK cohort and 6-8 points and 29% for the UK cohort. Conclusions The measurement properties of MSK-HQ were acceptable across countries, but seem more suited for group than individual level evaluation. Researchers and clinicians should be aware that some discrepancy exits and should take the observed measurement error into account when evaluating change in scores over time.
Impact of Surgeon Handedness in Manual and Robot-assisted Total Hip Arthroplasty
Authors: Kong Xiangpeng , Yang Minzhi , Li Xiang , Ni Ming , Zhang Guoqiang , Chen Jiying , Wei Chai
Published: December 2019

Background The purpose of this study was to examine whether surgeon handedness could affect cup positioning in manual total hip arthroplasty (THA), and whether robot could diminish or eliminate the impact of surgeon handedness on cup positioning in robot-assisted THA.Methods Fifty-three patients who underwent bilateral robot-assisted THA and sixty-two patients who underwent bilateral manual THA between August 2018 and July 2019 in our institute were respectively analyzed in this study. When the difference between the bilateral anteversion or inclination was greater than 5°, the patient was regarded as having different cup positioning between bilateral THA. Their demographics, orientation of acetabular cup and postoperative 3 month Harris hip score (HHS) were recorded for analysis.Results There were no significant difference in the gender, age, BMI, diagnosis's composition, preoperative and postoperative HHS between the robotic and manual group. Two left hips dislocated in the manual group. The anteversion of left hip was significantly larger than that of right hip (24.77±10.44 vs 22.44±8.67, p=0.043) in the manual group. There were no significant difference of cup positioning between bilateral robot-assisted THA. The patients in manual group were significantly more likely to have different cup positioning between bilateral hips than those in robotic group (77% vs 45%, p=0.000).Conclusions Surgeon's handedness had adverse impact on anteversion of the non-dominant side in manual THA and right-handed surgeons were more likely to place the left cup in larger anteversion. Robot could help surgeon eliminate the adverse impact caused by personal innate handedness.
The impact of ultrasonography on quality of cardiopulmonary resuscitation: a retrospective observational study
Authors: Lien Wan-Ching , Chong Kah-Meng , Chang Herman Chih-Heng , Cheng Su-Fen , Chang Wei-Tien , Huei-Ming Matthew , Chen Wen-Jone
Published: December 2019

Background: This study aims to evaluate the effect of ultrasonography (US) on quality of cardiopulmonary resuscitation (CPR), and US-related pause duration of pulse-checks.Methods: This retrospective observational study was conducted at the emergency department of National Taiwan University Hospital between April 2017 and May 2018. Video recordings for adult patients with non-traumatic cardiac arrest in designated resuscitation rooms were collected. The primary outcome was chest compression fraction (CCF) in the CPR with US group. The secondary outcome was pause duration of pulse checks with introduction of US or not. US-related pulse-checks were stratified into US during hands-off periods only (hands-off US), and US performing from hands-off to hands-on periods (continuous US). Results: A total of 153 patients were enrolled. Continuous US was performed in 116 patients. CCF was similar (92%) between the CPR with and without US groups. In the CPR with US group, pause duration was significantly longer in US-related pulse-checks than that without US (9.3±8.0 v.s. 7.3±4.7s, p<0.0001). Notably, longer pause was noted in the hands-off US, as comparing with that in the continuous US (18.3±16.4 v.s. 7.7±3.5s, p<0.0001). Conclusions: The introduction of US during CPR did not impact on CCF. Individual pause would not be lengthened if continuous US was performed while allowing chest compressions to be resumed. In addition, structured training, adequate facilities and manpower, and a timer reminding resumption of chest compressions would help sophisticated integration of US into CPR process.
Capturing the complexity of healthcare for people with Down syndrome in quality indicators - a Delphi study involving healthcare professionals and patient organisations
Authors: Mareeuw Francine A. van den Driessen , Coppus Antonia M.W. , Delnoij Diana M.J. , de Vries Esther
Published: December 2019

Background Insight into quality of healthcare for people with Down Syndrome (DS) is limited. Quality indicators (QIs) can provide this insight. This study aims to find consensus among participants regarding QIs for healthcare for people with DS.Methods We conducted a four-round Delphi study, in which 33 healthcare professionals involved in healthcare for people with DS and two patient organisations’ representatives in the Netherlands participated. Median and 75-percentiles were used to determine consensus among the answers on 5-point Likert-scales. In each round, participants received an overview of participants’ answers from the previous round.Results Participants agreed (consensus was achieved) that a QI-set should provide insight into available healthcare, enable healthcare improvements, and cover a large diversity of quality domains and healthcare disciplines. However, the number of QIs in the set should be limited in order to prevent registration burden. Participants were concerned that QIs would make quality information about individual healthcare professionals publicly available, which would induce judgement of healthcare professionals and harm quality, instead of improving it.Conclusions We unravelled the complexity of capturing healthcare for people with DS in a QI-set. Patients’ rights to relevant information have to be carefully balanced against providers’ entitlement to a safe environment in which they can learn and improve. A QI-set should be tailored to different healthcare disciplines and information systems, and measurement instruments should be suitable for collecting information from people with DS. Results from this study and two preceding studies, will form the basis for the further development of a QI-set.
Oligotrophic bacterium Hymenobacter latericoloratus CGMCC 16346 degrades the neonicotinoid imidacloprid in surface water
Authors: Guo Leilei , Dai Zhiling , Guo Jingjing , Yang Wenlong , Ge Feng , Dai Yijun
Published: December 2019

The intensive and extensive application of imidacloprid in agriculture has resulted in water pollution and risks to aquatic invertebrates. However, pure bacteria remediation of imidacloprid in surface water environments has not been studied. Here, we isolated an imidacloprid-degrading bacterium from a water environment, examined its imidacloprid degradation in pure culture and surface water, sequenced its genome, and compared its Clusters of Orthologous Groups (COG) protein categorization with that for another imidacloprid-degrading bacterium. The isolate was an obligate oligotrophic bacterium, Hymenobacter latericoloratus CGMCC 16346, which degraded imidacloprid via hydroxylation by co-metabolism in pure culture. Resting cells degraded 64.4% of 100 mg/L imidacloprid in 6 d in the presence of co-substrate maltose, and growing culture degraded 40.8% of imidacloprid in 10 d. H. latericoloratus CGMCC 16346 degraded imidacloprid in surface water without co-substrate supplementation and retained imidacloprid-degrading activity after 30 d. The half-life of imidacloprid in surface water was decreased from 173.3 d in the control to 57.8 d by CGMCC 16346 inoculation. Genome sequencing and COG analysis indicated that carbohydrate metabolism and transport, cell wall/membrane biogenesis, and defense mechanisms are enriched in H. latericoloratus CGMCC 16346 compared with the copiotrophic imidacloprid-degrading Pseudoxanthomonas indica CGMCC 6648, indicating that H. latericoloratus CGMCC 16346 is adapted to live in oligotrophic water environments and biofilms. H. latericoloratus CGMCC 16346 is a promising bioremediation agent for elimination of imidacloprid contamination from surface water.
Ventriculoperitoneal shunt insertion in human immunodeficiency virus infected adults: a systematic review and meta-analysis
Authors: Loan James JM , Poon Michael TC , Tominey Steven , Mankahla Ncedile , Meintjes Graeme , Fieggen Graham
Published: December 2019

Background
Hydrocephalus is a common, life threatening complication of human immunodeficiency virus (HIV)-related central nervous system opportunistic infection which can be treated by insertion of a ventriculoperitoneal shunt (VPS). In HIV-infected patients there is concern that VPS might be associated with unacceptably high mortality. To identify prognostic indicators, we aimed to compare survival and clinical outcome following VPS placement between all studied causes of hydrocephalus in HIV infected patients.

Methods
The following electronic databases were searched: The Cochrane Central Register of Controlled Trials, MEDLINE (PubMed), EMBASE, CINAHL Plus, LILACS, Research Registry, the metaRegister of Controlled Trials, ClinicalTrials.gov, African Journals Online, and the OpenGrey database. We included observational studies of HIV-infected patients treated with VPS which reported of survival or clinical outcome. Data was extracted using standardised proformas. Risk of bias was assessed using validated domain-based tools.

Results
723 unique study records were screened. Nine observational studies were included. Three included a total of 75 patients with tuberculous meningitis (TBM) and six included a total of 49 patients with cryptococcal meningitis (CM). All of the CM and two of the TBM studies were of weak quality. One of the TBM studies was of moderate quality. One-month mortality ranged from 62.5-100% for CM and 33.3-61.9% for TBM. These pooled data were of low to very-low quality and was inadequate to support meta-analysis between aetiologies. HIV-infected patients with TBM had higher risk of one-month mortality compared with HIV non-infected controls (odds ratio 3.03; 95% confidence-interval 1.13- 8.12; p=0.03).

Conclusions
The evidence base is currently inadequate to inform prognostication in VPS insertion in HIV-infected patients. A population-based prospective cohort study is required to address this, in the first instance.

Registration
International Prospective Register of Systematic Reviews (PROSPERO) registration ID: CRD42016052239
BIOCONVERSION OF SECONDARY PRODUCTS OF PROCESSING OF GRAIN CEREALS CROPS
Authors: Vitol I. S. , Igoryanova N. A. , Meleshkina E. P.
Published: December 2019

A method has been developed for the production of organic ingredients from secondary products resulting from the high-quality grinding of triticale and wheat into flour, which involves the enzymatic action of amylolytic enzymes to release starch polysaccharides while preserving the native properties of dietary fibers and biologically active substances associated with them. To a large extent, the features of the properties of the obtained ingredients are due to the number and composition of the components of dietary fiber of grain, as well as the morphological features of their structure. It is shown that the viscosity of aqueous colloidal systems at a concentration of soluble dietary fiber of the ingredient 0.5 % increases 11 times; at a concentration of 1.0 %   — 30 times, forming a viscous gel-like structure. This allows them to be used for gelling, thickening and stabilization of aquatic food systems. The use of ingredients with a high content of NLP in baking is possible only taking into account their water absorption capacity. A method for the enzymatic modification of secondary products of processing of grain triticale was developed. On the basis of the study of the kinetics and efficiency of the effect of proteolytic and cellulolytic enzyme preparations (EP) and their compositions, optimal conditions for enzymatic modification (the EP dosage is 0.5…0.75 units of PA/g of bran, 0.3…0.4 units of CA/g of bran, the optimum temperature is 40–50 °С, pH is 5.0 and 3.5, the duration of reactions is 1.5 hours) have been determined. The use of cellulolytic EP allowed to increase the amount of reducing substances and soluble protein by 1.5–2.5 times in comparison with the control sample. The biomodified bran obtained using the MEC «Shearzyme 500 L» + «Neutrase 1.5 MG» and «Viscoferm L» + «Distizym Protacid Extra» has a high degree of hydrolysis of non-starch polysaccharides and proteins, is characterized by a certain ratio of high-, medium-, low-molecular peptides and amino acids, has different functional and technological properties. They can be used in the production of a wide range of general-purpose, functional and treatmentand-prophylactic food products.
NMR — SPECTROSCOPY TECHNIQUE FOR SALMON FISH SPECIES QUALITY ASSESSMENT
Authors: Abramova L. S. , Kozin A. V. , Shashkov A. S.
Published: December 2019

NMR-spectroscopy was used for development of the criteria which characterize the chilled and frozen fish quality. It has been shown that 1H-NMR experiments can be used as quality factor to measure the concentration of inosine, hypoxanthine and inosine-5’-monophosphate generated during the fish storage. The quality factor is expressed by the K1 correlates well with the sensory quality of chilled Atlantic salmon (Salmo Salar), whereas, quality factor H is more sensitive for measuring the quality characteristics of frozen pink salmon (Oncorhynchus gorbuscha), chum salmon (Oncorhynchus keta), sockeye salmon (Oncorhynchus nerka).
DEVELOPMENT OF PASTERIZATION MODES FOR HIGH-SUGAR CANS IN CONTINUOUS ACTING PASTEURIZERS
Authors: Pokudina G. P. , Trishkaneva M. V. , Volkova R. A.
Published: December 2019

High-sugar canned fruits, such as jam, marmalade, confiture, are characterized by a high content of soluble dry solids and high acidity, which allows to apply to them pasteurization processes as heat treatment. In comparison with sterilization processes, heat treatment of hermetically sealed canned food during pasteurization is implemented at temperatures less than 100°C.

The article presents the results of the development of scientifically-based pasteurization modes for high-sugar canned food for industrial continuous-acting pasteurizers (CAP — continuous-acting pasteurizers) of open type with a temperature in the heating area less than 100°C. For today, such pasteurizers are widely spread due to the simplicity of their design, high productivity, with the option to reduce consumption of water, steam, electricity and to use it for the various types of packaging. So, the actual task of this article is the establishment of canned fruit pasteurization modes for such pasteurizers.

The development of pasteurization modes for high-sugar canned food using strawberry jam as a sample was carried out in the experimental equipment simulating the operation of a continuous-acting pasteurizer. The studies were implemented to confirm that the developed modes of heat treatment in the CAP as a matter of fact provide industrial sterility of the produced high-sugar canned food. Optimal pasteurization modes have the following parameters: heat treatment in an autoclave sterilizer at a heating temperature of the heating medium 97°C and stage-by-stage cooling of the products with water at temperatures 70°C, 50°C and 30°C.
State of the mortgage market in Russia at present stage
Authors: Zverev A. V. , Mandron V. V. , Mishina M. Y.
Published: December 2019

Mortgage market is a large segment in the economic system of the state and the development of this form of lending is influenced by certain factors. The article presents the features of mortgage lending in Russia. The analysis and assessment of the housing lending market in recent years in the conditions of instability of the national economy. The main problems that hinder the effective development of mortgage lending in modern economic conditions are identified.
To the question of «educational services»: economic and social aspects
Authors: Korotkov A. V. , Yarnykh Е. А. , Gorelova Т. Р.
Published: December 2019

The term «educational services» is widely distributed and with the word «paid» is present in the current legislation in the field of education. However, the question of the legitimacy of this category is being debated in the scientific literature and in the media. The purpose of the article is to economically substantiate the insolvency category «educational services» from the perspective of the theory of marketing services. Excluded services of exclusive education are formulated. The mechanism for reducing the quality of education is analyzed and the corresponding social and economic consequences for society in the conditions of a service, in fact, education paradigm are revealed.
The main types of budgets and their classification in various industrial enterprises
Authors: Fedorova E. Y.
Published: December 2019

Budget management is a necessary tool of management accounting in any enterprise, which provides a stable financial condition of the enterprise, increases financial and economic efficiency and provides an opportunity to strengthen the position of the enterprise in the market. To build the budgeting process, it is necessary to regulate it. In the formation of regulations of budgeting needed to develop a classifier of the budget, to develop a composition and a package of budget and reporting forms, to determine the order of formation of the budget, to develop the enterprise structure and assign the centers of financial responsibility.
Prospects for the development of Russian pharmaceutical products in the process of forming the single market of the Eurasian Economic Union
Authors: Abramov V. L.
Published: December 2019

The article analyzes the state and dynamics of the development of the Russian pharmaceutical industry. There is given an assessment of the state and trends of exports of its products to the member states of the Eurasian Economic Union, as well as the countries of the post-Soviet economic space. Opportunities and prospects for the development of the Russian pharmaceutical industry in the process of formation of the single market of the EEU, the use of regional economic integration opportunities are substantiated. Proposals have been formulated to increase the export potential and international competitiveness of the Russian pharmaceutical industry, to develop integration processes of forming a single pharmaceutical market for the member states of the EEU.
Quality management tools as a factor of instrument-making enterprise development
Authors: Menshikova M. A. , Piunova Y. V.
Published: December 2019

In the article the questions of formation of the analytical information for assessing the quality of the instrument-making enterprise. The indicators of quality, as well as the necessary initial information are given. The authors determined the importance of the procedure for determining and analyzing risks. The main stages of the risk management process are formulated. The necessity of identification of risks at all stages of the life cycle is established and the necessary measures to reduce the negative consequences of risk are developed. Defined performance targets QMS instrument - making enterprise.
Improvement of methods of cadastral valuation of real estate on the basis of urban development value of the territory. Part III
Authors: Osennyaya A. V. , Khakhuk B. A. , Kushu A. A. , Kolomytseva A. A.
Published: December 2019

In the article for the purpose of carrying out the careful analysis of the results of an assessment on the basis of town-planning value developed by us the evaluation of results of approbation from the point of view of efficiency and efficiency of its use in practice is carried out. It is established that the obtained cadastral value is as close as possible to the market value, which will determine the economically justified value of real estate for the purpose of their effective and socially-fair taxation.
On the determination of economic nature of intellectual capital as a component of regional intellectual and innovation activities
Authors: Ostaschenko T. V.
Published: December 2019

This paper discusses the economic nature and interrelation of categories of human capital, human potential, intellectual capital, intellectual potential, innovation potential. Author's definitions of the categories regional intellectual and innovation potential, regional intellectual and innovation climate, regional intellectual and innovation capital, regional intellectual and innovation activities are offered. The importance of the research topic is related to the insufficient theoretical basis of the concept of regional intellectual capital.
The mechanism of interaction between government and business structures in the development of the innovative potential of the region
Authors: Rudenko I. R. , Bessonova E. A.
Published: December 2019

The mechanism of interaction between government and business structures in the development of the innovation potential of a region in Russia requires constant development and improvement, since only a balanced interaction of government and business at the regional level makes it possible to fully develop socio-economic development and, accordingly, realize the region's innovative potential. The authors examined the above problem and proposed a mechanism for the implementation of investment projects with the participation of regional authorities and business structures.
Production of agricultural food products as a branch of specialization of the Republic of Bashkortostan
Authors: Tsyrkaeva E. A. , Aralbayeva G. G.
Published: December 2019

The article deals with the specialization of the regions of the Volga Federal district on the basis of statistical data presented for the period 1991-2017. The Research was carried out on the basis of the localization coefficient, the index of the level of specialization, the coefficient of per capita production; the place of the Republic of Bashkortostan on the basis of the rating of regions for agricultural production was revealed. The forecast of indicators of specialization of the Republic of Bashkortostan, which allowed to determine the position of the region in the coming years for the production of agricultural products.
Organizational-economic mechanism of regional development of high-tech engineering
Authors: Abrashkin M. S.
Published: December 2019

The article contains a study on the prospective tendencies and problems of the development of science-intensive enterprises of rocket and space engineering. Information base of statistical interpretation of results, using methods of logical analysis, synthesis of information and graphical interpretation of results. It was revealed that the primary tasks in the development of science-intensive enterprises of the rocket and space machine-building are the instability of financial results, the state monopoly on organizational design and ensuring the increase in the quality of products. It was proved that the development of rocket and space machine-building enterprises requires improvement of the levers and methods of state regulation of the industry and attraction of private investors. It is also necessary to concentrate all functions and levers of management of the space industry, especially in terms of financial flows, product quality, control of production activities.
Analysis of the effectiveness of the implementation of the outsourcing models in the enterprise
Authors: Kulikov A. I.
Published: December 2019

The article presents the results of analysis of the five most likely scenarios for the unstable market situation development, which may need to be outsourced. Automotive production is considered as an operating environment, including individual parts or assemblies which can be outsourced or manufactured on their own. Scenario analysis was carried out by means of simulation modeling which allowed us to calculate a range of performance indicators which served as the basis for making a decision on the expediency of switching to outsourcing.
Evaluation of the efficiency of the processes of improving the economic business of the industrial company
Authors: Meshcheryakova Yu. S.
Published: December 2019

The evolution of the definitions of «efficiency» and «improvement» are often identified in all kinds of economic research, and therefore the actual aspect is not their differentiation and justification of obvious differences, but the expression of their importance to each other and the relationship in the process of managing the company's industrial sector.
Current state and prospects for development of Russian-Chinese cooperation in the fuel and energy sector
Authors: Ketsba B. I. , Allayarova N. I.
Published: December 2019

The article analyzes the current state of relations between Russia and China in the fuel and energy sector. Special attention is paid to the format of interaction at the highest political level. The authors attempt to give some forecasts of the future development of Russian-Chinese relations in the field of energy.
The emergence of digital economy in a globalizing world: theoretical aspect
Authors: Korolkov V. E. , Erofeeva T. A.
Published: December 2019

This article is devoted to the theoretical justification of the phenomenon of «digital economy». In the course of the study, the author notes that the economy is a dynamically developing and complex system that determines the relationship between partners both within markets and countries, and at the world level. Thanks to the achievements of scientific and technological progress, network marketing is increasingly used, markets are formed within the boundaries of the Internet. The author concludes that at this stage of development it should be noted that the economy is based on the widespread use of digital technologies.
Prospects for the formation of the telecommunications market in the region (on materials of Smolensk region)
Authors: Lomachenkov D. A.
Published: December 2019

Тhe article deals with the main directions of development of the telecommunications market in the Smolensk region, the analysis of prospects and threats of introduction of innovative digital technologies in the socio-economic infrastructure of the region, the role of telecommunications as a factor of increasing the competitiveness of the regional economy.
Modern native x-ray control technologies used at the enterprises of space mechanical engineering
Authors: Arkhipova L. М. , Voeyko O. А.
Published: December 2019

The article considers the modern Russian non-destructive methods at the enterprises of the space industry. The X-ray method for revealing defects by the device «Gradient» has been studied in details. A new method is described, with the use of innovative equipment that allows to obtain a better image of the monitored object, as well as significantly reduce the negative impact on personnel.
Modeling the transfer of ionizing radiation flux in multilayered barriers
Authors: Ostrik A. V. , Bugay I. V.
Published: December 2019

The variant of Monte Carlo method for calculation of transfer of ionizing radiation having quanta energy of Eph=1-200keV is considered. The hybrid numerical and analytical method of calculation is offered. At numerical realization of each trajectory photo-absorption of quanta is considered analytically and other types of interactions (Compton and Relay scatterings, fluorescence) are realized in a random way. Calculations results for transfer of radiation having Plank spectrum are given for flat multilayered barriers.
A study of the influence of thin nitride films of aluminium on the fracture of solid cast steel
Authors: Scriabin M. L. , Chukhlova S. S.
Published: December 2019

The article considers the features of the formation of primary and secondary stone - like fracture formed at high temperatures and enriched by phases soluble in austenite in the form of small particles or films-melted eutectic. For studies of the patterns of occurrence of the defect was 8 different heats selected for further studies were made of the micro-sections. The study of the structure contributed to the identification of the main components that have a destructive effect on the metal, as well as to find out which structures prevail to a greater or lesser extent for the development of microlocal deformation that provokes destruction.
Formulation of the problem of ground stations scheduling under resource restrictions
Authors: Kucherov B. A.
Published: December 2019

The tasks solving during ground stations scheduling to ensure satellites control are considered. The hierarchy of scheduling problems is analyzed. Ground stations scheduling problem is compared with general scheduling problem. Various approaches to develop schedule of ground stations are analyzed. Mathematical formulation of ground stations scheduling problem is presented. Research of possible ways to increase efficiency and quality of ground stations scheduling was performed using presented mathematical formulation of mentioned problem.
Algorithm for optimal allocation of limited resources based on the game iteration method
Authors: Vilisov V. Ya.
Published: December 2019

The article proposes an algorithm for solving a linear programming problem (LPP) based on the use of its representation in the form of an antagonistic matrix game and the subsequent solution of the game by an iterative method. The algorithm is implemented as a computer program. The rate of convergence of the estimates of the solution to the actual value with the required accuracy has been studied. The software implementation shows a high speed of obtaining the LPP solution with acceptable accuracy in fractions or units of seconds. This allows the use algorithm in embedded systems for optimal control.
Method for determining deflections of round plates under the action of harmonic transverse load
Authors: Kravchuk A. S. , Kravchuk A. I.
Published: December 2019

For the first time, the problem of bending a circular plate under the action of the harmonic distribution of the intensity of a transverse load was solved. For the first time, the solution was constructed by lowering the order of the differential operator in the plate deflections equation from fourth to second order, which made it possible to divide the solution of the problem into two stages. At the first stage, the boundary conditions for the equality to zero of vertical displacements of the plate and the smoothness of its deflections in the center were satisfied. At the second stage, either the edge pinching condition or zero bending moment condition on the edge of the plate was satisfied.
A ADPF 153 E O CASO HERZOG: UMA JUSTIÇA DE TRANSIÇÃO À BRASILEIRA
Authors: Sales Aragão Adriele Priscila , Wagner Daize Fernanda
Published: December 2019

Partindo da ideia de que Supremo Tribunal Federal estaria se omitindo de cumprir a função de controle de convencionalidade, o que geraria embaraços à justiça de transição brasileira, este artigo tem como objetivo investigar a Arguição de Preceito Fundamental 153 e o Caso Herzog, objeto de decisão da Corte Interamericana de Direitos Humanos. Para tanto, utilizou o conceito de controle de convencionalidade e a perspectiva do Direito Internacional dos Direitos Humanos nos respectivos casos. Como metodologia principal, a investigação é jurídico-propositiva, com abordagem qualitativa e pesquisa bibliográfica. Os resultados demonstraram que o STF ignora o debate internacional sobre a internacionalização do direito interno, confirmando a hipótese.