bluuebunny/crossref_metadata_2025 huggingface dataset:
PATENT PORTFOLIO MANAGEMENT: ISSUES AND OPPORTUNITIES
Authors: Mishra Ashutosh , Shukla Shruti
Published: January 2025

Patent is a very assuring yet delicate right. The commercial monopoly it brings along with itself is strong enough to attract inventors and investors in creation of new inventions but the legal aspects of a patent needs smart and efficient management to protect the invention and make it capable enough for the grant of patent. This process is called patent portfolio management and goes hand in hand with each step of the product development. Being a commercial right, it is very important to package the patent attractively and smartly so that it not just protects itself from infringement but also appeals well to the relevant consumer market. This management can be done by patent portfolio managers who must carry knowledge of multiple disciplines like IP Analysis, Data Mining and IP Database Management with themselves. This is a new emerging field that holds great potential for new professional and also assists inventors in protecting their invention at every stage of product development. This paper explains the process and various phases of Patent Portfolio Management and the related aspects in detail and also the challenges involved.
Super-Aged Society and Dementia: Community-Based Integrated Management Strategies Learned from the Kobe Project
Authors:   The Korean Society of Cognitive Therapeutic Exercise, Kim Chun-Nam , Park Su-Hyun
Published: January 2025

In Korea, which is expected to enter a super-aged society by 2025, the proportion of the elderly population is rapidly increasing owing to the aging of baby boomers, which is expected to lead to an increase in the dementia population.
In Japan, Kobe City promoted various studies and policies to create a dementia-friendly community through the ‘Kobe Project,’ with the aims of dementia prevention and early intervention. Therefore, this study aims to discuss the tasks of the super-aged society in Korea and seek countermeasures through the Kobe Project, which alleviated the social burden of the super-aged society.
Korea provides long-term and customized care services for the elderly in need of care and is strengthening medical and care services by introducing the National Dementia Responsibility System in 2017. However, policies for relieving accidents and victims caused by dementia are insufficient. Kobe City, Japan, in cooperation with the World Health Organization (WHO) and Kobe University, conducted the ‘Kobe Project’ for approximately 80,000 elderly individuals in their 70s or older. The Kobe Project first examines the relationship between caring risks by evaluating whether the elderly have cognitive decline. Second, it explores the effectiveness of cognitive decline interventions for high-risk groups of dementia, including dementia prevention education and cognitive training. Third, the Kobe Project presents a regional model that realizes early detection and intervention for dementia. Fourth, it suggests an accident relief system plan for accidents caused by dementia patients that are not resolved within the existing social security area.
The Kobe Project is evaluated as an exemplary case of dementia management and is used as a policy model in other regions of Japan and around the world.
The Kobe Project is an example of strengthening the institutional safety net and establishing a dementia-friendly environment with an integrated community-based management model that protects both patients with dementia and victims. Dementia is no longer a problem only for individuals and families; it is time to develop effective countermeasures through cooperation between the state, local governments, and members of society.
THE EFFECT OF CROSSWORD PUZZLE LEARNING MEDIA ON STUDENTS' SCIENCE LEARNING OUTCOMES IN FIFTH-GRADE SDN 28 SINGKAWANG
Authors: Angreini Anggie , Marhayani Dina Anika , Utama Erdi Guna
Published: January 2025

The purpose of this study was to describe whether there is a difference in learning outcomes between students who are taught using crossword puzzle media and those who do not use crossword puzzle media in the science subject of grade V students of SDN 28 Singkawang and to describe how much influence the crossword puzzle learning media has on students' learning outcomes in the science subject of grade V SDN 28 Singkawang . The data in this study are the learning outcomes of the control class and the learning outcomes of the experimental class. The data source is grade V students of SDN 28 Singkawang. The sampling technique used in this study is non-probability . The data collection technique used is an essay test technique . Based on the results of the study, 26 students from class A were obtained as the control class and 26 students from class B as the experimental class. The control class obtained the highest score in the pre-test, which was 90, and the post -test class was 95. The lowest score in the pre-test was 43 and the post-test was 43. The experimental class obtained the highest score in the pre-test, which was 90, and the post-test was 95. The lowest score in the pre-test was 43 and the post-test was 60. The results of this study can be assumed in the 2013 curriculum in learning Natural Sciences.
ANALYZING CHILDREN'S TREATMENT AND ROLE IN INDONESIAN RESEARCH: CURRENT PRACTICES AND ETHICAL CONSIDERATIONS
Authors: Sidik Ezis Japar , Utomo Dhafid Wahyu , Subandowo Dedy
Published: January 2025

This study investigates the treatment and role of children in research practices in Indonesia. Using a content analysis of six research-based articles, this study aims to understand the current state of involving children in research in Indonesia. The articles were selected based on three criteria: the focus of child research, the disciplines of research, and the availability of English language versions. The content analysis was carried out by systematically examining how each article addressed ethical considerations, participant involvement, and the research methodologies employed, particularly in relation to children as research participants. The findings show that researchers often fail to provide adequate treatment for child participants and tend to treat them similarly to adult participants throughout the research process. Additionally, children's involvement in research is not always voluntary, as evidenced by the lack of informed consent or consent from adult guardians, posing a risk to their safety and well-being. To address these issues, this study highlights the need for ethical guidelines that encompass specific aspects, such as obtaining genuine informed consent, safeguarding child welfare during research, and respecting children's unique vulnerabilities and rights. Existing frameworks like UNICEF's Ethical Research Involving Children (ERIC) guidelines or international research ethics codes could be adapted to the Indonesian context. Other relevant research institutions, such as the Ministry of Research, Technology and Higher Education, universities, and research communities, must also establish these guidelines to ensure ethical standards are upheld in research with children.
THE INFLUENCE OF PERCEPTION OF THE TEACHING PROFESSION ON THE INTEREST IN BECOMING A TEACHER: A CASE STUDY OF PROSPECTIVE TEACHERS
Authors: Meiriza Mica Siar , Rahmadani Nasution Putri , Muliani Rizka , Hidayati Sabilah , Nasution Selviana
Published: January 2025

This study examines how teachers' perceptions influence individuals' interest in choosing a profession as a teacher. The aim is to uncover the impact of these perceptions on the interest in becoming a teacher, with the expectation that the findings will provide new insights for teacher recruitment strategies in the future and enhance the quality of education. The results are expected to offer recommendations for designing teacher professional development programs and serve as a reference for future researchers in exploring other factors influencing interest in becoming a teacher. The research type used is quantitative research with the dependent variable being the interest in becoming a teacher, and the independent variable being teachers' perceptions. The population in this study consists of students from the Economic Education Department, Faculty of Economics, Universitas Negeri Medan, class of 2021. The sample in this study is 70 students. Due to the relatively small population size, a saturated sampling technique was used. Data collection was conducted using a questionnaire, and data analysis was performed using simple regression. The findings of this study are expected to provide valuable insights into how teachers' perceptions impact students' career choices. By understanding these perceptions, education stakeholders can develop targeted strategies to improve teacher recruitment and retention. Moreover, the results could guide the creation of policies and programs aimed at improving the image of the teaching profession, thereby attracting more individuals to consider teaching as a viable and rewarding career. The study also has the potential to influence educational institutions and policymakers in designing more effective teacher professional development initiatives.
Integrating AI, ML, and RPA for end-to-end digital transformation in healthcare
Authors: Kiran Babu Macha
Published: January 2025

The amalgamation of Artificial Intelligence (AI), Machine Learning (ML), and Robotic Process Automation (RPA) possesses significant potential for facilitating comprehensive digital transformation in healthcare. Nonetheless, disjointed initiatives, scaling issues, and restricted compatibility impede broad adoption. This article examines current frameworks and techniques, highlighting the cohesive integration of AI, ML, and RPA to optimize healthcare workflows, enhance real-time decision-making, and improve patient outcomes. The research emphasizes progress in predictive analytics and individualized treatment frameworks while examining RPA's function in automating repetitive procedures, including billing and patient data administration, to enhance operational efficiency and alleviate administrative constraints. A comparative study of existing research reveals differing levels of precision and accuracy in RPA implementations, with Ghulaxe Vivek (2024) attaining the highest performance metrics (94% accuracy, 85% precision), while other studies provide significant insights. Findings illustrate the need for integrated, scalable architectures that leverage the strengths of AI, ML, and RPA to facilitate digital transformation that is both sustainable and effective in health care.
Leveraging digital twin technology for end-to-end supply chain optimization and disruption mitigation in global logistics
Authors: Oluwakemi Adesola  , Itunu Taiwo  , Damilola David Adeyemi
Published: January 2025

The global logistics landscape is experiencing unprecedented transformation, driven by rapid technological advancements and increasing complexity of supply chain networks. Digital twin technology emerges as a revolutionary approach to supply chain management, offering comprehensive solutions for optimization and disruption mitigation. This comprehensive review examines the transformative potential of digital twin technologies in revolutionizing global logistics through systematic analysis of existing literature, implementation frameworks, and case studies. Our investigation reveals that digital twin implementation can potentially reduce operational costs by 30-40%, decrease supply chain disruption times by up to 60%, and improve overall supply chain resilience through advanced predictive modeling. The research synthesizes evidence from multiple domains, demonstrating digital twins' capacity to address critical challenges in contemporary supply chain management. By exploring emerging trends, implementation mechanisms, and critical challenges, this review provides a balanced perspective on the opportunities and limitations of digital twin technologies. The findings suggest that while digital twins present promising solutions for supply chain optimization, successful implementation requires careful consideration of technical infrastructure, data integration strategies, and organizational capabilities.
Assessments of serum ferritin and iron status among hypothyroidism patients with and without levothyroxine treatment
Authors: Haider D. Abdullah  , Salim Abd Mohammed Ghanim  , Hussein Ali Obaid Dalboohi
Published: January 2025

Background: Hypothyroidism is a common disorder in which the thyroid gland does not synthesize and secrete enough thyroid hormone into the circulation. Hypothyroidism is diagnosed with a low concentration of plasma thyroxin (T4) and triiodothyronine (T3) with an elevation in the concentration of thyroid-stimulating hormone (TSH). Hypothyroidism symptoms include tiredness, weight gain, loss of concentration, and be unable to tolerate cold temperatures. The main treatment for hypothyroidism is hormone replacement therapy with levothyroxine.

Material and methods: This cross-sectional study was conducted between March 2022 and April 2023. Sixty males and females were enrolled in the study, ages 25 to 50. All samples were collected from the private medical laboratory and general hospitals in Baghdad city. These patients were classified into 2 groups; Group 1 included 30 patients newly diagnosed with hypothyroidism without thyroid hormone therapy and Group 2 included 30 hypothyroid patients treated with levothyroxine.

Results: According to the results there were no significant differences in mean patient’s age (p=0.317) and gender distribution (p=0.584) between the three studied groups. There were also significantly lower T3 and T4 levels and significantly higher TSH levels among untreated hypothyroid patients (p< 0.001). Serum iron levels and serum transferrin saturation were significantly higher among levothyroxine-treated patients (p< 0.001); although total iron binding capacity (TIBC) and serum ferritin levels were significantly higher among untreated patients (Group 1) (p < 0.001 and p=0.006 respectively).
Candida Auris: Review on worldwide spread, seems prone to antifungal and disinfectant therapies
Authors: Vaishnavi V Khairnar  , Yogesh S Wankhede  , Amol R Patil
Published: January 2025

In recent years, C. auris has become a leading source of invasive fungal diseases, with outbreaks occurring across all continents. This fungus infection poses a severe hazard to healthcare, with outbreaks primarily affecting older patients with comorbidities and high fatality rates. Controlling epidemics has been challenging because to poor detection, fast spread, and resistance to environmental cleaning methods. C. auris is currently the major cause, or one of the leading causes of invasive fungal infections in many healthcare facilities, primarily due to its potential may exhibit or acquire resistance to many types of antifungal medications and due to their Ability to persevere in healthcare circumstances. Timely diagnosis by swift and reliable identification. techniques and dedication in infection control procedures can assist to limit the spread of C. auris, and prevent and manage epidemics
A review of phyto therapeutic approaches to manage skin complications in immune deficiency
Authors: Yadala Prapurna Chandra  , Kongi Kavyasudha  , Shaik Fathima Reenu
Published: January 2025

Human skin, the largest organ of the body, plays a crucial role in immune defense and homeostasis. This review explores the phyto-therapeutic approaches for managing skin entanglements related with immune deficiency, including conditions such as psoriasis, eczema, and vitiligo. The skin functions as an immune organ, housing various immune cells that engage in surveillance and response to pathogens. However, a compromised immune system can lead to increased susceptibility to skin disorders.

Allopathic medicines, while effective, often come with significant side effects and risks, prompting a growing interest in herbal medicine as a safer alternative. This review analyzes the logical proof supporting the utilization of different natural phytomedicines, their mechanisms of action, and their potential benefits in treating skin diseases. A comprehensive table highlights key herbal plants, their dynamic constituents and their applications in skin issues accentuating their calming and immunomodulatory properties.

The findings suggest that herbal remedies, such as neem, turmeric, and aloe vera, offer promising therapeutic options with minimal side effects. However, further research is needed to validate their efficacy and safety in clinical settings. This review aims to provide insights into the advantages and limitations of phytotherapy, paving the way for future research directions and therapeutic strategies in dermatology.
Adult-onset Rasmussen encephalitis: A late presentation case report
Authors: Ximena Cuzco N  , Daniel Guamán F  , John Romero C  , Andrés Roca F  , Juan Domínguez
Published: January 2025

Rasmussen's encephalitis is a chronic neuroinflammatory disease predominantly affecting one cerebral hemisphere, with an unknown etiology but associated with potential autoimmune and infectious mechanisms. Although its incidence is highest between 6 and 10 years of age, 10% of cases occur in adults, as demonstrated by the reported case of a 39-year-old male. This progressive inflammatory condition is characterized by cerebral volume reduction, a crucial finding in the differential diagnosis of neurological disorders. Magnetic resonance imaging plays a fundamental role in its diagnosis. This case highlights the clinical and imaging features of the disease in adult patients, an uncommon but clinically relevant presentation for medical practice.
Unveiling the adverse effects of escitalopram: A case series analysis
Authors: CHRISTEENA MARY VIJI  , MERIN.V. JOLLY  , HARIKRISHNAN S  , RINKU ELSA REJI  , JACOB JESURUN R S
Published: January 2025

Escitalopram is a Selective Serotonin Receptor Inhibitor (SSRI) prescribed for the management of anxiety, major depressive disorders, agitation, and dementia. Hyponatremia is a familiar side effect of SSRIs; however, there are only a few pieces of literature that give evidence of escitalopram-induced hyponatremia and hyponatremic encephalopathy. SSRIs are also known to cause rare neurological side effects, such as extrapyramidal symptoms like tremulousness, Parkinsonism, which often go unlisted. SSRIs may cause visual hallucinations.
Analisis Perkuatan Dinding Penahan Tanah Kantilever dalam Pengendalian Longsor di Sungai Pelus Purwokerto
Authors: Lestari Diah Dwi , Al Fathoni M. Agus Salim , Azizi Amris
Published: January 2025

Sungai Pelus Arcawinangun Purwokerto mengalami tingkat erosi yang signifikan, berpotensi terjadinya longsor yang dapat mengakibatkan kerusakan infrastruktur dan pemukiman. Kondisi ini tidak hanya mengancam keselamatan masyarakat, tetapi juga menimbulkan ancaman terhadap keberlanjutan ekosistem sungai. Salah satu upaya dalam mengatasi masalah longsor adalah dengan membuat dinding penahan tanah. Pada penelitian ini digunakan dinding penahan tanah tipe kantilever, karena dinding penahan kantilever dapat digunakan dengan ketinggian lebih dari 6 meter. Tujuan dari penelitian ini adalah mengetahui dimensi dinding penahan tanah yang aman, mengetahui gaya geser, momen guling, dan daya dukung tanah, serta mengetahui nilai SF (Safety Factor) dinding penahan. Analisis dinding penahan kantilever ini dimulai dari pengumpulan data tanah, kemudian membuat pemodelan, serta dilakukan perhitungan secara manual dan menggunakan aplikasi plaxis v8.2. Hasil analisis diperoleh dimensi dinding penahan kantilever dengan tinggi 8 m, lebar atas 0,3 m, dan lebar bawah 4 m. Besarnya gaya geser sebesar 95,153 kN, momen guling 279,116 kN/m, dan daya dukung tanah 95898 kN/m. Bedasarkan Perhitungan manual diperoleh faktor keamanan terhadap guling sebesar 2,7 > 2 , faktor keamanan terhadap geser sebesar 2,04 > 1,5, dan faktor keamanan terhadap daya dukung sebesar 943,73 > 3. Sedangkan dari Perhitungan plaxis diperoleh faktor keamanan (SF) sebesar 62,0080
Short-Term Effect of Different Physical Therapy Modalities on Neck Mobility in Healthy Young Adults
Authors: Oymak Soysal Ayşe Nur , Kaş Özdemir Atiye , Şimşek Şule , Baş Aslan Ummuhan , Bergin Merve
Published: January 2025

Purpose: To investigate the short-term effects of hot pack, intermittent traction and low-level laser combined with stretching exercises and stretching exercises alone on neck mobility in individuals with no past pain history but flexibility loss.

Material and Methods: Sixty (60) participants were randomly divided into 4 groups. All participants performed cervical stretching exercises. Cervical intermittent traction wad added to Group I, low level laser therapy was added to group II, hot pack was added to group III. Cervical range of motion (ROM), occiput-wall distance (OWD) and, coronoid process- tragus distance (TCD) was assessed at the beginning and end of the study.

Results: The results of this study showed that all physical therapy modalities were effective in increasing lateral flexion ROM and OWD score (p.05) to stretching exercises alone in increasing neck mobility.

Conclusion: In conclusion, both stretching exercises alone and combined with hot pack, intermittent traction, and low-level laser increased neck mobility in healthy individuals. Even if not combined with any modality, stretching exercises alone may increase neck mobility.
Retrospective Evaluation of Diet Compliance on Plasma Amino Acid and Vitamin Levels in Patients with Phenylketonuria
Authors: Aytop Kol Buse , Şimşek Papur Özlenen , Kulu Bahar , Arslan Nur
Published: January 2025

Purpose: In this study, it was aimed to compare the plasma amino acid and blood vitamin/mineral levels in patients with classical phenylketonuria and healthy controls.
Material and Methods: 54 patients with classical phenylketonuria and 22 healthy controls (76 children, 47 boys, 61.8%) were included in the study. The patient group was divided into two subgroups as high adherence to phenylalanine-restricted diet (HAD, 16 patients) and low adherence to this diet (LAD, 38 patients) according to the mean plasma phenylalanine level of the patients of the previous year. Anthropometric measurements (body weight and height and standard deviation score values), plasma phenylalanine and other amino acid levels, hemoglobin, vitamin B12, folic acid, vitamin D, zinc, ferritin levels of all groups were recorded.
Results: The mean age of the entire study group was 10.1 ± 3.6 (minimum: 3.5 - maximum: 17) years. There was no significant difference between the phenylketonuria group and the control group in terms of age, gender distribution and anthropometric data. There was a significant difference between the three groups in terms of plasma phenylalanine levels (plasma phenylalanine levels 299.0 ± 77.2; 813.7 ± 356.6 and 47.5 ± 15.9 µmol/L in HAD, LAD and control groups respectively, p= 0.001). Tryptophan was significantly lower in the HAD group than in the LAD and control groups (p= 0.001 and p= 0.006, respectively). Lysine was found to be significantly higher and histidine was lower in the HAD group than the control group (p= 0.016 and p= 0.008, respectively). Hemoglobin, vitamin B12, folic acid and 25-OH vitamin D levels were found to be significantly higher in the PKU patient group compared to healthy children and no difference between zinc and ferritin levels.
Conclusion: As a result, in patients with phenylketonuria who comply with the diet and whose anthropometric data are in the normal range, no significant deterioration in vitamin/mineral and amino acid values is observed. Compliance of the patients with a diet restricted from phenylalanine will both reduce the neurological effects and ensure that the patient is nutritionally balanced.
Investigation of Epidermal Growth Factor Receptor Pathway Related, Exosomal miRNAs in Non-Small Cell Lung Cancer Cases
Authors: Koç Altuğ , Leblebici Asım , Karakuş Haydar Soydaner , Aldağ Ceyda , Erdoğan Kadri Murat , Saka Güvenç Merve , Özgür Su , Göksel Tuncay , Başbınar Yasemin
Published: January 2025

Background and Purpose: Recently, the “Epidermal Growth Factor Receptor” gene and its related pathways are potential targets in precision medicine for “Non-Small Cell Lung Cancer” cases. The presented study is a proof of concept study, which utilizes exosomal miRNAs as an easy and cheap liquid biopsy approach.
We aim to investigate, 4 exosomal miRNAs: miR-30b, miR-30c, miR-221-3p, miR-22-3p; and miR-1288 as control. They are defined in the literature previously.
Methods: Thirty-six samples from distinct Non-Small Cell Lung Cancer cases are analyzed. Exosomes are extracted from the plasma of the patients; miRNA isolation, cDNA synthesis, and real-time quantitative polymerase chain reactions are done and ∆/∆ Ct method is used for relative quantification.
Results: The control miR1288 is expressed in all of the samples except one. The two miRNA targets miR-30c and miR-22-3p produced polymerase chain reaction curves successfully. The remaining two miRNAs (miR-30b, miR-221-3p) produce weak polymerase chain reaction curves.
Conclusion: miR-30b, miR-221-3p, miR-30c, and miR-22-3p are reported to be associated with lung cancer previously, but they have not been studied in a patient series before. In our study, the exosomal miR-30c, and miR-22-3p are successfully derived from the plasma of cancer cases and they could be potential biomarkers.
Pengembangan RPP Berbasis Model Discovery Learning Pada Materi Eubacteria Di Tingkat MA
Authors: Muhammad Ivan Danang
Published: January 2025

Dalam kegiatan pembelajaran banyak sekali model yang dapat dipilih oleh guru untuk melaksanakan kegiatan pembelajaran, namun tidak semua model pembelajaran tersebut dapat diterapkan pada semua kelas. Karena pada kenyataannya setiap kelas memiliki karakteristik siswa yang berbeda-beda sehingga guru harus memilih model pembelajaran yang tepat. Penelitian pengembangan ini bertujuan untuk mengembangkan rencana pelaksanaan pembelajaran (RPP) yang baik dan layak digunakan pada tingkat MA dikarenakan banyaknya siswa yang mengalami stres karena pembelajaran di kelas. Jenis penelitian yang dikembangkan adalah penelitian dan pengembangan (Research and Development) yang menggunakan model 4D (Define, Design, Develop, Disseminate). Prosedur pengembangan menggunakan metode discovery learning terdiri dari analisis masalah dalam pembelajaran, pengembangan awal RPP, revisi, dan uji RPP di sekolah. Hasil pengembangan ini adalah RPP yang baik dalam pembelajaran yang sudah diuji coba di sekolah. Subjek penelitian meliputi guru dan siswa sedangkan sampel diambil dari kelas X MIPA. Hasilnya diperoleh keterlaksanaan RPP 100%. RPP dinyatakan baik dan layak digunakan karena telah divalidasi. Penelitian ini diharapkan dapat diterapkan di berbagai sekolah.
Persepsi Guru IPA Terhadap Penerapan P5 Pada Kurikulum Merdeka Di SMP Negeri Kecamatan Telanaipura Kota Jambi
Authors: Azmi Alfath Ulil , Novallyan Devie , Chatib Muhsin
Published: January 2025

Permasalahan pada penelitian masih banyaknya faktor penghambat dalam pelaksanaan Kurikulum Merdeka di sekolah seperti kurangnya pengalaman guru dalam pelaksanaan kurikulum ini, guru masih kesulitan dalam menyusun ATP, CP, Modul ajar atau prosedur yang berhubungan dengan program Kurikulum Merdeka. Tujuan penelitian mengetahui penerapan P5 oleh guru IPA dan mengetahui persepsi Guru IPA terhadap Penerapan P5 di SMP Negeri Kecamatan Telanai Pura Kota Jambi. Metode penelitian yang digunakan metode kualitatif dengann pengumpulan data berupa observasi, wawancara dan dokumentasi. Teknik pemeriksaan keabsahan data menggunakan triangulasi data. Diketahui penerapan P5 telah terlaksana dengan baik. Hal ini terbukti telah diterapkan P5 di masing-masing sekolah seperti di SMP Negeri 7 Kota Jambi telah diterapkan 3 tema yaitu suara demokrasi melaksanakan pemilihann ketua OSIS, gaya hidup berkelanjutan melaksanakan daur ulang sampah dan kearifan lokal dengan melaksanakan bazar. SMP Negeri 17 Kota Jambi telah menerapkan 2 tema yaitu bangunlah jiwa raga melaksanakan drama anti bullying dan gaya hidup berkelanjutan daur ulang sampah.  SMP Negeri 19 Kota Jambi menerapkan 3 tema suara demokrasi dengan melaksanakan pemilihann ketua OSIS, gaya hidup berkelanjutan menanam tanaman hidroponik dan kearifan lokal melaksanakan bazar. Guru berpendapat P5 memberikan dampak positif kepada peserta didik dapat mengembangkan potensi peserta didik dan dapat menumbuhkan moral siswa.
Kata Kunci: Persepsi, Guru IPA, Kurikulum Merdeka.
Efek Pemberian Tugas Akhir Pembelajaran Terhadap Hasil Belajar Siswa Pada Mata Pelajaran IPA Terpadu
Authors: Gustina Teti , Musyaddad Kholid , Tomi Dodo
Published: January 2025

Permasalahan pada penelitian ini yaitu rendahnya hasil belajar siswa. Metode pemberian tugas adalah metode pembelajaran yang memberikan kesempatan pada peserta didik dalam melaksanakan tugasnya, metode pemberian tugas biasanya digunakan supaya hasil belajar siswa lebih meningkat dan lebih maksimal. Penelitian ini bertujuan untuk menguji teori apakah pemberian tugas setiap akhir pembelajaran berpengaruh tehadap hasil belajar siswa pada mata pelajaran IPA Terpadu. Metode yang digunakan adalah kuantitatif dan jenis penelitian yang digunakan adalah quasi eksperimen. Teknik pengambilan sampel yaitu total sampling dengan sampel berjumlah 17 siswa pada kelas kontrol maupun eksperimen. Data dianalisis menggunakan uji normalitas, uji homogenitas, dan uji hipotesis melalui Ms. Excel dan SPPS Versi 26. Analisis data menggunakan uji “t” dan uji effect size cohen’s D. Skor yang diperoleh pada kelompok eksperimen sebesar 70 sedangkan pada kelompok kontrol sebesar 47,5. Nilai rata-rata atau mean yang diperoleh dari kedua kelompok tersebut yaitu kelompok eksperimen sebesar 86,07 dan kelompok kontrol sebesar 60. Hal tersebut dibuktikan melalui uji T yang telah diterapkan yaitu sebesar 0,000 < 0,05. Berdasarkan perhitungan effect size menggunakan Cohen’s D diperoleh hasil belajar sebesar 2,66. Berdasarkan data yang diperoleh dapat disimpulkan bahwa terdapat pengaruh Pemberian Tugas Setiap Akhir Pembelajaran Terhadap Hasil Belajar Siswa Mata Pelajaran IPA Terpadu.
Kata Kunci: Hasil Belajar, Pemberian Tugas, IPA
BIMBINGAN KARIR UNTUK MENUMBUHKAN ETOS KERJA ISLAMI SANTRI
Authors: Mahmudah  , Khaudli Muhammad Imam , Amalia Zahrotul
Published: January 2025

Career guidance is a part of the need to foster the work ethic of Islamic students at the Mukhtar Syafa'at Blokagung Banyuwangi Islamic Boarding School. The purpose of this study is to analyze the implementation and supporting factors and inhibitors of career guidance in fostering the work ethic of students at the Mukhtar Syafa'at Blokagung Banyuwangi Job Training Center. The research method uses a qualitative approach, with data collection techniques through observation, interviews, and documentation. Data analysis uses the Miles and Huberman interactive model consisting of data reduction (data reduction), data display (data presentation) and drawing conclusions/verification and drawing conclusions. The results of this study indicate that career guidance in fostering the work ethic of Islamic students is carried out in the form of work practices and worship. One of the strategies provided by career guidance is to involve students in the work training body, as well as preparing production facilities and infrastructure. The existence of the work training agency is able to foster a work ethic in students, so that students know that Islamic work ethic is a belief of a Muslim, that work is related to the purpose of his life, namely trying to obtain Allah's pleasure through work or good deeds
Сравнительный анализ эффективности бета-блокаторов в терапии хронической сердечной недостаточности на основании методик атрибутивной статистики и анализа межлекарственных взаимодействий
Authors: Жукова Ольга Вячеславовна , Шимановский Николай Львович
Published: January 2025

Бета-адреноблокаторы — одна из групп препаратов, которые приводят к уменьшению смертности как от всех, так и от сердечно-сосудистых причин, снижению потребности в госпитализациях, уменьшению выраженности клинических проявлений хронической сердечной недостаточности, улучшению функционального статуса и качества жизни больных. Из группы бета-адреноблокаторов в клинических рекомендациях приводятся 4 МНН: бисопролол, карведилол, метопролол, небиволол. Проведен сравнительный анализ результатов клинических исследований (MERIT-HF, CIBIS II, COPERNICUS, SENIORS) клинической эффективности использования метопролола, бисопролола, карведилола и небиволола в терапии хронической сердечной недостаточности, а также оценка данных лекарственных препаратов на предмет потенциальных лекарственных взаимодействий. Наибольшую эффективность в терапии хронической сердечной недостаточности показали бисопролол и метопролол. Амиодарон, верапамил и дилтиазем относятся к лекарственным препаратам, не рекомендованным к использованию у пациентов с диагнозом тяжелая хроническая сердечная недостаточность. Это характерно для всех бета-блокаторов. Также обращают внимание межлекарственные взаимодействия между всеми анализируемыми бета-блокаторами и аминофиллином и теофиллином. Взаимодействия идентифицируются как опасные (на фоне совместного приема регистрируются снижение активности бета-блокатора и повышение активности аминофиллина и теофиллина). Для карведилола выявлено наибольшее количество межлекарственных взаимодействий. Для данного бета-блокатора регистрируются опасные взаимодействия с бета-адреномиметиками (формотерол, салметерол) – бронхолитическими средствами, широко использующимися при обструкции на фоне бронхиальной астмы, хронической обструктивной болезни легких.
Сравнительная фармакокинетика нового дипептидного миметика BDNF ГСБ-106 у крыс и кроликов
Authors: Колыванов Геннадий Борисович , Литвин Александр Алексеевич , Кравцова Оксана Юрьевна , Грибакина Оксана Геннадьевна , Жердев Владимир Павлович
Published: January 2025

На крысах и кроликах изучена фармакокинетика ГСБ-106 (гексаметилендиамид бис-(N-моносукцинил-L-серил-L-лизина)), обладающего антидепрессантоподобной активностью, после его однократного введения внутрь в виде фармацевтической субстанции. Концентрацию ГСБ-106 в плазме крови животных определяли методом высокоэффективной жидкостной хроматографии с масс-спектрометрическим детектированием. Период полувыведения ГСБ-106 из плазмы крови крыс и кроликов составил 0,6 и 1,3 ч соответственно. С помощью аллометрического метода проведена межвидовая экстраполяция периода полувыведения ГСБ-106. Прогнозируемая продолжительность периода полувыведения ГСБ-106 у человека составила ~3 ч.
Сопоставление in silico и in vivo результатов исследования эмбриотоксического и тератогенного эффектов оригинальных 3-циано-1,4-дигидропиридинов, производных цианотиоацетамида
Authors: Бочев Александр Владимирович , Бибик Елена Юрьевна , Кривоколыско Сергей Геннадиевич
Published: January 2025

Одной из актуальных проблем современной фармакологии является влияние лекарственных средств на эмбрион и плод в период беременности. В ходе эксперимента реализовано сравнительное исследование токсического действия на плод новых соединений 3-циано-1,4-дигидропиридинов, производных цианотиоацетамида, in silico и in vivo. Реализован компьютерный скрининг токсичности изучаемых гетероциклических соединений с использованием онлайн-ресурса ProTox 3.0 — Prediction of toxicity of chemicals. Исследование эмбриотоксического и тератогенного эффектов осуществлялось на 5 группах крыс-самок по 16 особей в каждой, путем воздействия веществ в течение всего срока беременности в 10-кратной разовой дозе 50 мг/кг. Препаратом сравнения был выбран циклофосфамид, известный своими тератогенными свойствами. В результате экспериментов, выполненных на самках белых крыс в период беременности, не было установлено достоверного влияния на имплантацию и эмбриогенез изучаемых фармакологических веществ. Изучаемые соединения 3-циано-1,4-дигидропиридинов, производные цианотиоацетамида, с лабораторными шифрами mar-137, mar-003 и mar-021 при ежедневном внутрижелудочном применении в дозе 50 мг/кг не обладают эмбриотоксическим и тератогенным эффектами.
Пролиферативная активность экстракта листьев гинкго двулопастного (Ginkgo biloba L.) в условиях ожоговой травмы кожи крыс
Authors: Ажикова Альфия Кадыровна
Published: January 2025

В статье описаны результаты иммуногистохимической оценки особенностей пролиферативных процессов клеток кожи в условиях ожоговой травмы и на фоне коррекции экстрактом листьев гинкго двулопастного (Ginkgo biloba L.). Исследование проводили на нелинейных крысах мужского пола средней массы 220 г возраста 6 – 7 мес. Моделирование ожоговой травмы проводили в условиях эфирной наркотизации в межлопаточной области спины. Рандомизацию животных осуществляли следующим образом: I группа — животные, не подвергшиеся ожоговому воздействию — интактные (n = 10); II группа — животные, получавшие на фоне ожоговой травмы кожи внутрижелудочно дистиллированную воду и наружно изотонический раствор NaCl (n = 10); III группа — животные, получавшие на фоне ожоговой травмы кожи аппликации линиментом алоэ (с содержанием суммы производных антрацена в пересчете на алоэ-эмодина не менее 0,5 %) и внутрижелудочное введение дистиллированной воды (n = 10), начиная со второго дня после ожога в течение 21 дня; IV группа — животные, получавшие на фоне ожоговой травмы кожи аппликации (в дозе 0,09 мг в пересчете на полисахариды) и внутрижелудочное введение (в дозе 50 мг/кг/сут) экстракта листьев гинкго двулопастного (n = 10), начиная со 2 дня после ожога в течение 21 дня. В условиях ожогового воздействия происходили выраженные деструктивные преобразования, отечные и воспалительные изменения кожи. Ежедневные аппликации на постдеструктивную поверхность кожи спины и внутрижелудочное введение экстракта листьев гинкго двулопастного в течение 21 дней приводили к ослаблению воспалительного процесса на 50 %, p < 0,001, к активации пролиферативного потенциала клеток кожи на 45 %, p < 0,001, к снижению отёчных изменений на 40 %, p < 0,01, и ускорению восстановления постдеструктивной поверхности кожи на 40 %, p < 0,01, по сравнению со значениями животных без коррекции ожоговой травмы. Доказанная пролиферативная активность экстракта листьев гинкго двулопастного на фоне ожоговой травмы кожи позволяет считать перспективными разработки на его основе лекарственных средств, обладающих эффектом стимуляции постожоговой репарации кожи.
Влияние 2-(1,1-диметил-1H-бензо[e]индолин-2-ил)-5,6,7-трихлор-1,3-трополона (JO122) на энергетический метаболизм опухолевых клеточных культур
Authors: Гненная Надежда Владимировна , Чембарова Татьяна Владимировна , Филиппова Светлана Юрьевна , Межевова Ирина Валентиновна , Новикова Инна Арнольдовна , Гончарова Анна Сергеевна , Саяпин Юрий Анатольевич
Published: January 2025

Метаболический сдвиг в сторону окисления глюкозы в лактат определяется как отличительная черта клеток опухолей различных типов. Более того, измененный клеточный метаболизм был идентифицирован как один из характерных признаков рака, что сделало его перспективной мишенью для лекарственной терапии. Проведена оценка влияния 2-(1,1-диметил-1H-бензо[e]индолин-2-ил)-5,6,7-трихлор-1,3-трополона (JO122) на энергетический метаболизм клеточных культур опухолей. Клеточные культуры рака шейки матки HeLa, аденокарциномы толстой кишки HT-29 и немелкоклеточного рака легкого H1299 культивировали в средах с добавлением JO122 в течение 1 и 24 ч. Производили оценку изменения энергетического фенотипа клеток на анализаторе внеклеточных потоков Seahorse XFp (Agilent, США). С целью нормализации полученных результатов производили окраску клеток ядерным красителем Hoechst 33342 (Life Technologies, США) с последующим подсчетом клеток в имиджере Lionheart FX (BioTek, США). Нормализацию полученных данных производили с использованием программного обеспечения Seahorse Wave Desktop 2.6 Software (Agilent, США). Полученные результаты демонстрируют снижение уровня гликолиза при культивировании клеточных культур с JO122 в течение 24 ч. При культивировании с JO122 в течение 24 ч интенсивность гликолиза в культурах HeLa, HT29, H1299 снизилась на 13,3, 46,1 и 23,8 %, соответственно (p ≤ 0,05).
Pengaruh aksesi dan dosis pupuk SP-36 terhadap pertumbuhan dan hasil kacang bogor (Vigna subterranea L. Verdc.)
Authors: Darudriyo Darudriyo , Novica Siti Rezeki , Setyono Setyono , Yuliawati Yuliawati
Published: January 2025

Kacang bogor atau bambara groundnut merupakan jenis tanaman legum asal Afrika yang sudah lama beradaptasi di Indonesia. Produktivitas kacang bogor di Indonesia masih tergolong rendah dan perlu ditingkatkan. Peningkatan produktivitas kacang bogor dapat dilakukan melalui pemupukan. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian berbagai dosis pupuk SP-36 terhadap pertumbuhan dan hasil beberapa aksesi kacang bogor. Penelitian dilaksanakan menggunakan rancangan acak kelompok (RAK) 3 ulangan dan 2 faktor, yaitu asal aksesi (Jampang, Cibenda, dan Waluran) dan dosis pupuk SP-36 (0%, 50%, 100%, 150% dari dosis rekombinasi). Peubah yang diamati berupa tinggi tanaman, jumlah daun, diameter kanopi, luas daun, diameter batang, jumlah bunga, bobot segar dan kering brangkasan, bobot segar dan kering polong total, jumlah polong bernas, cipo, serta total. Hasil penelitian menunjukkan aksesi Waluran memiliki keunggulan pada peubah tinggi tanaman, jumlah daun, diameter kanopi, jumlah bunga, jumlah polong total dan jumlah polong bernas. Pemberian SP-36 dengan dosis 150% rekomendasi menghasilkan jumlah bunga, bobot polong total dan bobot polong bernas terbaik. Aksesi Waluran yang diberi SP-36 150% rekomendasi menghasilkan jumlah bunga dan bobot kering brangkasan yang tinggi.
Pengaruh dosis kompos kipahit (Tithonia diversifolia (Hemsley) A. Gray) terhadap pertumbuhan dan hasil tiga aksesi kemangi (Ocimum basilicum L.)
Authors: Rahayu Arifah , Yuliawati Yuliawati , Aripin Agung
Published: January 2025

Kemangi berpotensi untuk dikembangkan secara luas di Indonesia karena memiliki banyak keunggulan dan manfaat. Peningkatan hasil kemangi dapat dilakukan dengan pemberian pupuk organik, salah satunya kompos kipahit. Penelitian ini bertujuan untuk untuk mengetahui pengaruh dosis kompos kipahit terhadap pertumbuhan dan hasil tiga aksesi kemangi. Penelitian dilaksanakan pada bulan Mei-Juli 2021 bertempat di Kebun Percobaan  Desa Jambuluwuk,   Kecamatan Ciawi, Kabupaten Bogor dengan ketinggian ±580 m dpl. Penelitian ini menggunakan RAL faktorial 3 ulangan. Perlakuan pertama adalah aksesi kemangi (Kadudampit, Ciaruteun dan Cidolog), perlakuan kedua adalah dosis kompos kipahit (kontrol (0%N dan 100%N-urea) 50%N-kipahit, 100%N-kipahit, 150%N-kipahit). Hasil penelitian menunjukkan bahwa aksesi kemangi asal Kadudampit memiliki daun paling luas, dan bobot segar serta kering panen paling tinggi. Aplikasi kompos kipahit dengan dosis 50%N sampai 150%N menghasilkan diameter batang, panjang cabang, dan luas daun kemangi terbaik. Kemangi yang diberi 50%N-kipahit sampai 150%N-kipahit memiliki kering tajuk serta panen tidak berbeda nyata dengan yang diberi 150%N-urea. Aksesi Kadudampit yang diberi 100%N-kipahit dan 150%N-kipahit memiliki bobot akar kering nyata lebih berat dibandingkan yang diberi dosis pupuk lain.
PROFITABILITAS, SOLVABILITAS DAN RETURN SAHAM: ANALISIS PADA PERUSAHAAN PERBANKAN INDONESIA
Authors: Pramesti Dewi Hayuningtyas
Published: January 2025

Latar belakang dari penelitian ini adalah kondisi return saham yang diproxykan menggunakan aktual return, dari perusahaan perbankan yang mengalami fluktuasi sejak tahun 2017 – 2021. Tujuan dari penelitian ini adalah untuk menginvestigasi faktor-faktor yang dapat mempengaruhi retun saham yang dalam hal ini diproxykan menggunakan variabel Return on Assets (ROA) dan Debt to Equity Ratio (DER). Metode penelitian yang digunakan adalah desain kuantitatif menggunakan data sekunder yang diperoleh dari indeks InfoBank15 Indonesia dengan tahun pengujian 2017 – 2021 yang diuji menggunakan regresi linier berganda. Hasil pengujian pada penelitian ini memperlihatkan bahwa kedua variabel bebas berpengaruh negatif dan tidak signifikan terhadap return saham. Dengan demikian dapat disimpulkan bahwa kondisi Return Saham tidak dipengaruhi signifikan oleh kondisi profitabilitas dan solvabilitas pada perusahaan perbankan yang terdaftar di indeks InfoBank15.
ANALISIS PENERAPAN ASET TETAP BERDASARKAN PERNYATAAN STANDAR AKUNTANSI PEMERINTAH (PSAP) NO. 07
Authors: Reutna Komala Mona , Kusuma Indra Cahya , Didi Didi
Published: January 2025

Aset adalah sumber ekonomi yang memiliki nilai kekayaan yang di miliki suatu entitas yang digunakan dalam memberikan manfaat sosial dan ekonomi. Penelitian ini bertujuan untuk mengetahui dan menganalisis kesesuaian penerapan akuntansi aset tetap pada Badan Litbang diklat Kumdil Mahkamah Agung RI terhadap PSAP No 07, yang diterapkan pada Badan Litbang diklat Kumdil Mahkamah Agung RI di Megamendung Kab. Bogor. Penerapan akuntansi aset tetap yang dimaksud meliputi pengakuan kepemilikan aset tetap, pengukuran, penyajian dan pengungkapan aset tetap. Desain Penelitian yang digunakan deskriptif kualitatif dengan melakukan analisis perlakuan aset tetap. Adapun hasil penelitian menunjukan bahwa pengakuan, pengukuran, penyajian dan pengungkapan aset tetap sudah sesuai dengan penerapan pernyataan standar akuntansi pemerintah PSAP No. 07 Pada Badan Litbang Diklat Kumdil Mahkamah Agung Republik Indonesia sudah sesuai dan efektif
ANALISA HARGA POKOK PRODUKSI TERHADAP REALISASI LABA
Authors: Harmoko Sukayat  , Dewi Fitrianti
Published: January 2025

PT. Kayu Abadi Timur merupakan perusahaan keluarga yang aktivitasnya di bidang pemotongan kayu khususnya kayu dari pohon meranti berlokasi di timur Indonesia yang dalam proses produksinya melalui tiga departemen, dimana selisih biaya produksi terdapat yang menguntungkan dan tidak. Biaya bahan baku dalam proses produksi terjadi selisih menguntungkan, hal ini terjadi karena bahan baku aktual lebih kecil dari standar bahan baku PT. Kayu Abadi Timur. Biaya tenaga kerja terdapat selisih menguntungkan pada departemen I dan II, namun untuk departemen III diperoleh selisih tidak menguntungkan. Selisih tidak keuntungan pada departemen III akibat dari biaya aktual lebih besar dibandingkan biaya tenaga kerja standar. Biaya overhead pabrik dalam selisih terkendali dan selisih volume untuk ketiga departemen menghasilkan selisih keuntungan. Harga pokok produksi yang dianggarkan perusahaan terjadi selisih menguntungkan dari harga pokok produksi sesungguhnya dan laba kotor mengalami kenaikan, maka terjadi perubahan pada penjualan bersih dan perubahan harga pokok penjualan sehingga menguntungkan bagi PT. Kayu Abadi Timur.
ANALISIS LABA KOTOR SEBAGAI ALAT EVALUASI PERENCANAAN LABA PADA ENTITAS USAHA
Authors: Melani Maria Magdalena , Firmansyah Firmansyah , Anwar Saepul
Published: January 2025

Penelitian ini memiliki tujuan untuk dapat menganalisis laporan keuangan pada entitas usaha Donat Madu Cihanjuang Outlet, Cabang Gunung Batu untuk periode Oktober - Desember 2023 dengan tujuannya untuk dapat mengetahui margin laba kotor serta variabel-variabel yang mempengaruhi pertumbuhan dan penurunan margin tersebut. Metodologi penelitian menggunakan deskriptif kualitatif yang digunakan dalam memperoleh dan mengumpulkan data yang diperlukan untuk penelitian ini adalah observasi. Kemudian alat analisis yang digunakan bersumber dari alat analisis laba kotor, yaitu Selisih Laba Kotor, Selisih Harga Jual, Selisih Harga dari Harga Pokok Penjualan, Selisih Kuantitas Penjualan,. Hasil penelitian menunjukkan bahwa laba kotor pada bulan Oktober 2023 adalah Rp. 41.721.210 atau 52%. Pada November 2023, terjadi penurunan sebesar Rp. 7.147.069 karena peningkatan biaya barang terjual akibat peningkatan persediaan bahan baku untuk produksi harian dan inovasi produk. Pada Desember 2023, terjadi peningkatan dari November sebesar Rp. 11.594.832 yang disebabkan oleh siklus liburan akhir tahun.