bluuebunny/crossref_metadata_2025 huggingface dataset:
Chimeric antigen receptor T-cells: a review on current status and future directions for relapsed/refractory multiple myeloma
Authors: Hamadeh Issam S. , Friend Reed , Mailankody Sham , Atrash Shebli
Published: August 2024

Although multiple myeloma is an incurable disease, the past decade has witnessed significant improvement in patient outcomes. This was brought about by the development of T-cell redirection therapies such as chimeric antigen receptor (CAR) T-cells, which can leverage the natural ability of the immune system to fight myeloma cells. The approval of the B-cell maturation antigen (BCMA)-directed CAR T, idecabtagene vicleucel (ide-cel), and ciltacabtagene autoleucel (cilta-cel) has resulted in a paradigm shift in the treatment of relapsed/refractory multiple myeloma. Overall response rates ranging from 73 to 97% are currently achievable. However, the limitations of KarMMa-1 and CARTITUDE-1 studies spurred the generation of real-world data to provide some insights into the effectiveness of ide-cel and cilta-cel among patients who were excluded from clinical trials, particularly those who received prior BCMA-targeted or other T-cell redirection therapies. Despite their unprecedented clinical efficacy in heavily pretreated patients, responses to CAR T remain non-durable. Although the underlying mechanisms of resistance to these agents haven’t been fully elucidated, studies have suggested that resistance patterns could be multifaceted, implicating T-cell exhaustion and tumor intrinsic mechanisms such as BCMA target loss, upregulation of gamma-secretase, and others. Herein, we provide a succinct overview of the development of CAR T-cells, manufacturing process, and associated toxicities/complications. In this review, we also recapitulate the existing literature pertaining MM CAR-T as well as emerging data from some of the ongoing clinical trials designed to mitigate the shortcomings of these agents, and improve the clinical efficacy of CAR T, especially in the relapsed/refractory setting.
The critical role of parents within a Learning Health Network
Authors: Ferraro Kerry , Leal Jenny , Sutton Anna , Peters Susan , Pinter Corinne
Published: August 2024

Parent members of the Pediatric Rheumatology Care & Outcomes Improvement Network are an integral part of the Learning Health Network's work. Since early in the creation of the network, they have been a part of every Quality Improvement project, committee, and work group and have a role in governance on the Executive and Steering Committees. Members of the Parent Working Group (PWG) have played a role in developing QI measures used in the clinical setting as well as initiatives and projects like the guiding work of Treat-to-Target. The PWG also creates self-management supports, including toolkits for families and patients at all stages of life. This article will discuss how integrating parents as partners in a pediatric Learning Health Network is critical for the quality of care received by children with chronic illnesses and to improving outcomes.
Association between Ureaplasma urealyticum colonization and bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis
Authors: Chen Xianhong , Huang Xunbin , Zhou Qiujing , Kang Houxin , Qiu Huixian , Shi Lindong , Tang Hong , Zeng Shujuan
Published: August 2024

Background

Bronchopulmonary dysplasia (BPD) is the most prevalent chronic lung disease in preterm infants. Studies have shown that Ureaplasma urealyticum (UU) infection is linked to its pathogenesis. However, it remains controversial whether UU colonization in preterm infants increases the risk of developing BPD.

Objective

This study aimed to conduct a systematic review and meta-analysis to summarize the correlation between UU and BPD.

Methods

We searched PubMed, Embase, the Cochrane Library, Web of Science, Wanfang Database, Chinese National Knowledge Infrastructure Database, Chinese Science and Technique Journal Database, and the China Biology Medicine disc from their inception to March 15, 2024. We included cohort and case-control studies investigating the association between UU infections and BPD in preterm infants, adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The Newcastle-Ottawa Scale was used for quality assessment. The outcome was defined as the continued need for oxygen or respiratory support at 28 days after birth (BPD28) or at 36 weeks postmenstrual age (BPD36). Considering the potential publication bias in observational studies, we used a random-effects meta-analysis model, assessed heterogeneity (I2), performed subgroup analyses, evaluated publication bias, and graded the quality of evidence.

Results

The meta-analysis included 36 cohort studies encompassing 5,991 participants. Among these, 20 reported on BPD28, 13 on BPD36, and 3 on both. The results indicated a significant association between UU colonization and BPD28 (odds ratio (OR): 2.26, 95% confidence interval (CI): 1.78–2.85, P < 0.00001, 23 studies, very low certainty of evidence) and BPD36 (OR: 2.13, 95% CI: 1.47–3.07, P < 0.0001, 16 studies, very low certainty of evidence).

Conclusion

There is a correlation between UU colonization and the development of BPD in preterm infants. Future research should prioritize well-designed, large-scale, high-quality randomized controlled trials (RCTs) to comprehensively assess the risk of BPD in neonates following UU infection and to provide stronger evidence for clinical screening and prevention strategies to improve the prognosis of affected newborns.

Systematic Review Registration

https://www.crd.york.ac.uk/, identifier (CRD42024524846).
Neurological manifestations of immune origin after COVID-19 vaccination: retrospective case study
Authors: Granja López Juan , Estebas Armas Carlos , Lorenzo Dieguez Manuel , Puertas Muñoz Inmaculada , De Celis Ruiz Elena , Rigual Ricardo , Fernández-Fournier Mireya , Torres Iglesias Gabriel , Sánchez Velasco Sara , Tallón Barranco Antonio , Rogozina Olga , Ramírez Elena , González-Muñoz Miguel , Lacruz Ballester Laura
Published: August 2024

Objectives: To know the frequency and characteristics of neurological manifestations of probable immune origin occurring after exposure to COVID-19 vaccination. In addition, to pre-study the usefulness of the Spanish pharmacovigilance system and lymphocyte transformation test in establishing causality.

Methods: Retrospective case study, including patients admitted to the Neurology department from January 2021 to May 2022 with a probable neuroimmune disorder. Demographic, clinical and COVID-19 vaccination antecedent data were collected from medical records.

Results: From a total of 108 patients, 30 were excluded due to a different etiological diagnosis after follow-up. Thirty-six patients (46.2%) had received the COVID-19 vaccine in the previous 3 months (21.8% during the previous month). BioNTech-Pfizer vaccine was the most frequent in this group (63.9%). 69/108 were female and mean age 51.2 years (SD 22.59), with no significant difference with not recently-vaccinated (U-Mann Whitney, p = 0.256). The neurological syndromes found were (vaccinated/total): polyradiculoneuropathy (8/16), encephalitis (5/11), multiple sclerosis relapse (5/16), optic neuritis (1/4), myelitis (3/6), cranial neuropathy (6/10), aseptic meningitis (1/3) and others (7/11). Acute immunosuppressive treatment was administered in 61.1% of cases and 47.2% presented complete clinical improvement, without significant differences with non-vaccinated patients (chi-square, p = 0.570). Eleven vaccinated patients were studied in the pharmacovigilance office for possible adverse drug reaction. Causality according to the Spanish pharmacovigilance system (SPVS) algorithm was “Related” to COVID-19 vaccine (score ≥ 4) in 11 cases with positive in vitro study (lymphocyte transformation test) to polyethylene glycol-2000 and polysorbate-80 in 4 cases.

Conclusion: Neuroimmune disorders appearing after administration of COVID-19 vaccine do not seem to present important differentiating clinical and/or evolutive features. Delayed hypersensitivity to vaccine excipients could be one of the pathophysiological mechanisms, and lymphocyte transformation test is a useful tool to identify it.
Combination of traditional Chinese medicine and standard biomedical treatment for rosacea: a systematic review and a meta-analysis
Authors: Yu Ruoxi , Li Shuyan , Yang Yuting , Xie Chunguang , Chen Qiu , Liu Ya , Peng Sihan
Published: August 2024

Background

A combination of standard biomedical treatment and traditional Chinese medicine (TCM) has been suggested as a therapeutic approach for rosacea that may significantly lower the recurrence rate and clinical symptom scores. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the impact of this combination treatment on clinical symptom and TCM syndrome scores, as well as on the scores of the Dermatology Life Quality Index (DLQI), erythema index (EI), and interleukin 37 (IL-37) levels in patients with rosacea.

Methods

The PROSPERO registration number for the study is CRD42023472737. We systematically searched the PubMed, Embase, Web of Science, China National Knowledge Infrastructure Wanfang Database, China Biomedical Medicine database (CBM), and the VIP information resource integration service platform (cqvip) databases for RCTs (published from the beginning to September 2023, regardless of the language used) that compared the traditional Chinese medicine and standard biomedical treatment combination treatment to conventional anti-rosacea treatments. Our primary outcomes comprised the clinical symptom and TCM syndrome scores, and the scores of Dermatology Life Quality Index, erythema index, and IL-37 levels. We used a random-effects model to evaluate the pooled data.

Results

We identified 260 studies. Of these, 13 eligible studies were employed for analysis (N = 1,348 participants). Compared with other anti-rosacea treatments, the TCM and standard biomedical treatment combination treatment yielded an improved mean reduction in the clinical symptom score −2.24% [95% CI (–3.02 to −1.46), p < 0.00001], TCM syndrome score −4.42 [95% CI (–5.33 to −3.50), p < 0.00001], and the score of DLQI of −2.55 [95% CI (–3.73 to −1.36), p < 0.00001], EI of −151.97 [95% CI (–276.59 to −27.36), p < 0.00001], and IL-37 level −4.23 [95% CI (–4.95 to −3.51), p = 0.854], as well as in the overall effective rate risk ratio (RR) = 1.25 [95%CI (1.18, 1.32), p = 0.994] and the recurrence rate = 0.27 [95%CI (0.15, 0.46), p = 0.297].

Conclusion

The TCM and standard biomedical treatment combination treatment can provide a better outcome, including a reduction in the TCM syndrome and clinical symptom scores, and in the scores of DLQI, EI, and IL-37. Hence, this combination is a viable and more effective therapeutic approach for rosacea. However, these results should be considered cautiously because of uncertain evidence and the low quality of the study reports considered in this meta-analysis.

Systematic Review Registration:

website, identifier CRD42023472737.
The critical role of glutamine and fatty acids in the metabolic reprogramming of anoikis-resistant melanoma cells
Authors: Peppicelli S. , Kersikla T. , Menegazzi G. , Andreucci E. , Ruzzolini J. , Nediani C. , Bianchini F. , Calorini L.
Published: August 2024

Introduction: Circulating tumor cells (CTCs) represent the sub-population of cells shed into the vasculature and able to survive in the bloodstream, adhere to target vascular endothelial cells, and re-growth into the distant organ. CTCs have been found in the blood of most solid tumor-bearing patients and are used as a diagnostic marker. Although a complex genotypic and phenotypic signature characterizes CTCs, the ability to survive in suspension constitutes the most critical property, known as resistance to anoikis, e.g., the ability to resist apoptosis resulting from a loss of substrate adhesion. Here, we selected melanoma cells resistant to anoikis, and we studied their metabolic reprogramming, with the aim of identifying new metabolic targets of CTCs.

Methods: Subpopulations of melanoma cells expressing a high anoikis-resistant phenotype were selected by three consecutive rocking exposures in suspension and studied for their phenotypic and metabolic characteristics. Moreover, we tested the efficacy of different metabolic inhibitors targeting glycolysis (2DG), LDHA (LDHA-in-3), the mitochondrial electron transport chain complex I (rotenone), glutaminase (BPTES), fatty acid transporter (SSO), fatty acid synthase (denifanstat), CPT1 (etomoxir), to inhibit cell survival and colony formation ability after 24 h of rocking condition.

Results:Anoikis-resistant cells displayed higher ability to grow in suspension on agarose-covered dishes respect to control cells, and higher cell viability and colony formation capability after a further step in rocking condition. They showed also an epithelial-to-mesenchymal transition associated with high invasiveness and a stemness-like phenotype. Anoikis-resistant melanoma cells in suspension showed a metabolic reprogramming from a characteristic glycolytic metabolism toward a more oxidative metabolism based on the use of glutamine and fatty acids, while re-adhesion on the dishes reversed the metabolism to glycolysis. The treatment with metabolic inhibitors highlighted the effectiveness of rotenone, BPTES, SSO, and etomoxir in reducing the viability and the colony formation ability of cells capable of surviving in suspension, confirming the dependence of their metabolism on oxidative phosphorylation, using glutamine and fatty acids as the most important fuels.

Discussion: This finding opens up new therapeutic strategies based on metabolic inhibitors of glutaminase and fatty acid oxidation for the treatment of CTCs and melanoma metastases.
Advancing biomedical applications: an in-depth analysis of silver nanoparticles in antimicrobial, anticancer, and wound healing roles
Authors: Jangid Himanshu , Singh Sudhakar , Kashyap Piyush , Singh Avtar , Kumar Gaurav
Published: August 2024

Introduction: Silver nanoparticles (AgNPs) have gained significant attention in biomedical applications due to their unique physicochemical properties. This review focuses on the roles of AgNPs in antimicrobial activity, anticancer therapy, and wound healing, highlighting their potential to address critical health challenges.

Methods: A bibliometric analysis was conducted using publications from the Scopus database, covering research from 2002 to 2024. The study included keyword frequency, citation patterns, and authorship networks. Data was curated with Zotero and analyzed using Bibliometrix R and VOSviewer for network visualizations.

Results: The study revealed an increasing trend in research on AgNPs, particularly in antimicrobial applications, leading to 8,668 publications. Anticancer and wound healing applications followed, with significant contributions from India and China. The analysis showed a growing focus on “green synthesis” methods, highlighting a shift towards sustainable production. Key findings indicated the effectiveness of AgNPs in combating multidrug-resistant bacteria, inducing apoptosis in cancer cells, and promoting tissue regeneration in wound healing.

Discussion: The widespread research and applications of AgNPs underscore their versatility in medical interventions. The study emphasizes the need for sustainable synthesis methods and highlights the potential risks, such as long-term toxicity and environmental impacts. Future research should focus on optimizing AgNP formulations for clinical use and further understanding their mechanisms of action.

Conclusion: AgNPs play a pivotal role in modern medicine, particularly in addressing antimicrobial resistance, cancer treatment, and wound management. Ongoing research and international collaboration are crucial for advancing the safe and effective use of AgNPs in healthcare.
Qualitative and quantitative analysis of colorimetric response in different UV solar radiation level indicator bracelets based on photochromic substances
Authors: Aguilera J. , Cárdenas-González D. , Sánchez-Roldán C. , González S. , Bosch-García R. , Herrera-Ceballos E. , de Gálvez M. V.
Published: August 2024

Background and Objective

We are exposed to solar radiation from early childhood, so learning different photoprotection strategies is fundamental. As a primary prevention tool, knowledge of the solar ultraviolet radiation to which we are exposed is fundamental. There are devices based on the color change of photochromic substances when exposed to UV radiation which are widely used as a tool for children’s play. The aim was to assess both quantitatively and qualitatively the effectiveness of the use of these devices under different conditions of simulated sun exposure.

Materials and Methods

Ten commercial UV-indicating photochromic devices plus three pure photochromic substances were used. Photochromic devices belong to the spirooxazine family of molecules. They were exposed to different rates of UV radiation under a solar UV-visible simulator, and their velocity, degree of response, and color reversal time were analyzed both visually and objectively using a colorimeter based on three-dimensional CIE L*a*b* color space values. Activation response was also evaluated under different UV high-energy visible light wavelengths using different cut-off filters. Finally, the devices were exposed under high UV irradiance (corresponding to UVI of 10) and interposing sunscreens of different sun protection factors in order to evaluate their potentials as indicators for sunscreen re-application.

Results

All the devices and pure substances offered color change almost immediately under simulated solar radiation. From very low irradiances (UVI >3), they saturated color, and it was not possible to observe and measure color change. The time to color reversal took longer than activation (from 60 s to obtain initial values). When devices were exposed to a UVI of 10 with topical sunscreen overlay, color was observed after 1 min irradiation even under SPF of 50+ sunscreen. Photochromic devices were activated under both UVA and high energy visible light.

Conclusion

UV radiation indicators using photochromic substances which, although possible awareness-raising elements, are of limited use as indicators of UV radiation intensity and dosimetry. They are useful elements for detecting the presence/absence of UV radiation and do not distinguish between different UV radiation spectral bands. Moreover, their incorporation as photoprotective elements used by minors could lead to exposures that are not objectively controlled.
A deep learning radiomics model based on CT images for predicting the biological activity of hepatic cystic echinococcosis
Authors: Nijiati Mayidili , Tuerdi Mireayi , Damola Maihemitijiang , Yimit Yasen , Yang Jing , Abulaiti Adilijiang , Mutailifu Aibibulajiang , Aihait Diliaremu , Wang Yunling , Zou Xiaoguang
Published: August 2024

Introduction: Hepatic cystic echinococcosis (HCE) is a widely seen parasitic infection. Biological activity is crucial for treatment planning. This work aims to explore the potential applications of a deep learning radiomics (DLR) model, based on CT images, in predicting the biological activity grading of hepatic cystic echinococcosis.

Methods: A retrospective analysis of 160 patients with hepatic echinococcosis was performed (127 and 33 in training and validation sets). Volume of interests (VOIs) were drawn, and radiomics features and deep neural network features were extracted. Feature selection was performed on the training set, and radiomics score (Rad Score) and deep learning score (Deep Score) were calculated. Seven diagnostics models (based on logistic regression algorithm) for the biological activity grading were constructed using the selected radiomics features and two deep model features respectively. All models were evaluated using the receiver operating characteristic curve, and the area under the curve (AUC) was calculated. A nomogram was constructed using the combined model, and its calibration, discriminatory ability, and clinical utility were assessed.

Results: 12, 6 and 10 optimal radiomics features, deep learning features were selected from two deep learning network (DLN) features, respectively. For biological activity grading of hepatic cystic echinococcosis, the combined model demonstrated strong diagnostic performance, with an AUC value of 0.888 (95% CI: 0.837–0.936) in the training set and 0.876 (0.761–0.964) in the validation set. The clinical decision analysis curve indicated promising results, while the calibration curve revealed that the nomogram’s prediction result was highly compatible with the actual result.

Conclusion: The DLR model can be used for predicting the biological activity grading of hepatic echinococcosis.
Lippia alba—a potential bioresource for the management of Spodoptera frugiperda (Lepidoptera: Noctuidae)
Authors: Biswas Shreosi , Kundu Aditi , Suby S. B. , Kushwah Abran Singh , Patanjali Neeraj , Shasany Ajit Kumar , Verma Rajesh , Saha Supradip , Mandal Abhishek , Banerjee Tirthankar , Kumar Anil , Singh Anupama
Published: August 2024

Fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith), a threat to maize production systems, is a polyphagous pest of global significance. There is no registered bioinsecticide of botanical origin to provide green remedy against this pest of concern. The present study reports for the first time the potency of the polar and non-polar bioinsecticidal leads sourced from Lippia alba (Mill.) N.E. Br. leaves. Shade-dried leaves of L. alba were extracted and evaluated; based on preliminary bioassay, the ethyl acetate leaf extract of L. alba (LEAE) was found to be the most potent against FAW in the in vitro and in vivo studies. Ultraperformance liquid chromatography–quadrupole time-of-flight–mass spectrometric (UPLC-QToF-MS) analysis of LEAE revealed the rich chemical profile of 28 compounds, dominated by flavones, namely, naringenin, trihydroxy-dimethoxy flavone, and dihydroxy-trimethoxy flavone. Among others, glycosides, such as clerodendrin, calceolarioside E, forsythoside B, geniposide, and martynoside, and glucuronides, such as luteolin-7-diglucuronide, tricin-7-O-glucuronide, and luteolin-7-O-glucuronide, were also identified. LEAE exhibited exceptionally high in vitro [LC50 = 6,900 parts per million (ppm)] and in vivo (computed as damage score on a scale of 1–9) insecticidal activity against S. frugiperda, with no phytotoxicity at a dose as high as 20 times of LC50. LEAE also exhibited significant antifeedant, ovicidal, and growth regulatory activity at the 70–16,000 ppm (w/v) concentration range. In silico assessment revealed strong binding of martynoside, calceolarioside E, and forsythoside B with acetylcholinesterase-, sodium-, and chloride-dependent γ-aminobutyric acid (GABA) receptor and ryanodine receptor, respectively, facilitated by hydrogen bonds (conventional and C–H bonds) stabilized by hydrophobic pi–sigma, pi–pi stacked, pi–alkyl, and alkyl interactions. The present study established L. alba as a potential bioresource and secondary metabolite enriched LEAE as bioinsecticide for further product development.
Assessment of preoperative health-related quality of life in patients undergoing thyroidectomy based on patient-reported outcomes
Authors: Liu Lei , Xiang Yuqing , Xiong Lujing , Li Chao , Dai Wei , Hu Jinchuan , Shui Chunyan , Zhou Yuqiu , Wang Xu , Ma Linjie , Xu Nan , Hu Bintao , Cai Yongcong
Published: August 2024

Introduction

To evaluate the preoperative health-related quality of life (HRQoL) and influencing factors of HRQoL in patients undergoing thyroidectomy based on patient-reported outcomes.

Materials and methods

Patients who were diagnosed and treated in Sichuan Cancer Hospital from February 2022 to December 2022 and were scheduled to undergo thyroidectomy were included. Each participant completed the basic information questionnaire and patient-reported outcome assessment scales before surgery. HRQoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30), the Thyroid Cancer-Specific Quality of Life (THYCA-QoL), and the Hamilton Anxiety Scale (HAMA). The Wilcoxon rank sum test or the Kruskal-Wallis test was used to analyze the association between patient characteristics and HRQoL, and the variables with statistical significance were included in multiple linear regression analysis.

Results

450 patients were included in the study. According to the analysis of the THYCA-QoL scores, the psychological subscale was the most complained about. Anxiety was the most common symptom of the HAMA. Factors associated with worse general QoL on the EORTC QLQ-C30 included nondiagnostic/unsatisfactory fine-needle aspiration (FNA) result. Planned lateral neck dissection and nondiagnostic/unsatisfactory FNA result were influential factors for preoperative anxiety. Males and longer sleep duration were associated with better thyroid cancer-specific QoL, better general QoL, and less anxiety.

Conclusion

The preoperative HRQoL of patients undergoing thyroidectomy was generally good. Females, insufficient sleep duration, planned lateral neck dissection, and nondiagnostic/unsatisfactory FNA result were associated with worse preoperative HRQoL.
Stress and hope distinguish individuals with suicidal plan from suicide ideators among Chinese college students
Authors: Chen Naiche , Dai Zheru , Wang Yongguang
Published: August 2024

Background

Suicide among college students is a significant public health concern in China. While suicidal ideation serves as a crucial predictor of subsequent suicidal plans and behaviors, it is important to recognize that most instances of suicidal ideation may only be fleeting thoughts that do not progress to an actual plan. Therefore, it is imperative to identify the factors associated with the transition from suicidal ideation to a concrete plan. Consequently, this study aims to investigate whether certain frequently cited factors can differentiate individuals who have formulated a specific suicidal plan from those who have experienced suicidal thoughts without planning, based on data obtained through a cross-sectional survey.

Materials and methods

This survey was conducted as part of routine mental health assessments among second-year college students in October 2023. Data from a total of 4,858 second-year college students were utilized for the final analyses. Two survey questions were employed to identify past-year suicidal ideation and past-year suicidal plan. All participants were required to complete various assessments, including the Chinese version of Depression Anxiety Stress Scale 21 items (DASS-21), the Chinese version of Gratitude Questionnaire-six items (GQ-6), the Chinese version of Meaning in Life Questionnaire (MLQ), and the Chinese version of State Hope Scale (SHS).

Results

Among 4,858 participants, a total of 134 individuals (2.8%) were confirmed to have experienced past-year suicidal ideation. Out of these, 53 (1.1% overall) reported having a past-year suicidal plan, accounting for approximately 39.6% of those with suicidal ideation. Logistic regression analyses revealed that while most potential variables differentiated between students with and without suicidal ideation, only two factors stood out in distinguishing individuals with a suicidal plan from those who had not made such plans despite experiencing suicidal thoughts—presence of stress (OR=2.49, 95% CI: 1.04–5.96) and lower scores of hope agency (OR=0.84, 95% CI: 0.72–0.98).

Conclusion

These findings suggest that the stress may contribute to susceptibility for transitioning from mere thoughts to actual planning regarding suicide; conversely, hope agency appears to offer protection against this transition process. Therefore, we advocate for targeted interventions aimed at fostering hope among individuals who have encountered adverse and stressful life events.
The role of community resilience as a protective factor in coping with mental disorders in a sample of psychiatric migrants
Authors: Olcese Martina , Madera Francesco , Cardinali Paola , Serafini Gianluca , Migliorini Laura
Published: August 2024

Background

Over the past decade migration to Italy has increased significantly for various reasons including armed conflicts. Generally, the migration process is exposed to different risk factors during different periods of migration, which can compromise well-being and promote the onset or exacerbation of mental disorders. A community with resources and the perception of one’s community as resilient can be important protective factor in the context of migration.

Purpose

This study aims to understand which variables in migration predict an increase in perceived community resilience and to understand the role of community resilience in the relationship between mental disorders and subjective well-being in a sample of 100 adult migrants at the first consultation interview in the ambulatories of Psychiatry Unit.

Methods

After defining the inclusion and exclusion criteria, migrants were asked to fill out self-report questionnaires to collect socio-demographic data and to assess perception of mental disorders, perceived community resilience and perception of subjective well-being. Descriptive analysis, simple regression, and moderation analyses were conducted to test the hypotheses.

Results

The results show that the variable meaning attributed to the community with reference to the host community, migration with someone, and longer duration of stay in Italy contribute to increased perceptions of community resilience. In addition, a direct negative effect of mental disorders on subjective well-being and the moderating role of community resilience in relationship between mental disorders and subjective well-being have been demonstrated.

Conclusions

This result underscores the importance of perceived community resilience in mitigating the negative effects of mental disorders on subjective well-being. Perceiving one’s community as more resilient seems to protect against the impact of mental disorders on subjective well-being. Our results support an ecological model of migrants’ mental health that values the community and its resources in coping with mental disorders in the context of migration.
Artificial intelligence and job performance of healthcare providers in China
Authors: Zheng Qi , Jin Yun , Xu Xinying
Published: August 2024

Introduction

This study explores the influence of artificial intelligence (A.I.) applications on the job performance of healthcare providers, based on data from standardised-trained residents in the First People’s Hospital of Yunnan Province in China.

Methods

The ordinary least squares model is employed to examine the relationship between A.I. applications and job performance. To address potential endogeneity and missing variables, we utilise the propensity score matching method and alternative regression models.

Results

The findings indicate that the job performance of standardised-trained residents positively correlates with A.I. applications. This relationship remains robust after addressing endogenous and missing variables. Further discussion reveals that patients’ support mediates the relationship between A.I. and job performance. Under identical conditions, the job performance of female residents empowered by A.I. is found to be significantly better than that of their male counterparts. Conversely, no heterogeneity is observed regarding the impact of A.I. on the job performance of medical practitioners and clinical medical technicians.

Discussion

This study underscores the positive role of A.I. applications in enhancing the job performance of standardised-trained residents. The results highlight the mediating role of patient support and suggest gender-based differences in the efficacy of A.I. empowerment.
Effects of aerobic exercise combined with resistance training on body composition and metabolic health in children and adolescents with overweight or obesity: systematic review and meta-analysis
Authors: Liu Xuan , Li Qiang , Lu FuXiang , Zhu Dongsheng
Published: August 2024

Background

To systematically review the effects of aerobic exercise and resistance training on Metabolic Health in children and adolescents with overweight/obesity.

Methods

Employing a retrieval strategy that combines subject terms and free terms, searches were conducted in the CNKI, WanFangData, VIP, PubMed, Web of Science, Embase, and Cochrane Library databases up to October 31, 2023.

Results

A total of 29 studies involving 2,195 subjects were included. The combination of aerobic and resistance training significantly reduces body composition and metabolic health in children and adolescents with overweight or obesity, as evidenced by changes in various parameters (BMI, WC, FM, BF%, VO2max, TG, TC, HDL-C, LDL-C, HOMA-IR, FPG, INS). However, there were no significant differences observed in hs-CRP. Subgroup analyses further showed that changes in intervention measurement had a significant effect on the effectiveness of the intervention.

Conclusion

Aerobic exercise combined with resistance training has a positive impact on the physical health of children and adolescents with overweight/obesity. The recommended exercise prescription is at least three sessions of more than 60 min per week for 12 weeks or more for better health benefits.
Ceftriaxone-resistant Salmonella enterica serovar Newport: a case report from South India
Authors: Sumana Mahadevaiah Neelambike , Maheshwarappa Yogeesh D. , Rao Morubagal Raghavendra , Deepashree R. , Karthik M. V. S. Krishna , Shah Nikita K.
Published: August 2024

Salmonella enterica serovar Newport is a human pathogen underreported in most developing countries. It is known for causing gastroenteritis and extraintestinal infections. In this case report, we report the case of ceftriaxone-resistant Salmonella enterica serovar Newport from South India, causing acute gastroenteritis in a sixty-year-old female patient having a history of antimicrobial therapy and recent hospital admission. Serovar Newport, especially among antibiotic-exposed patients, poses a significant public health threat due to its ability to acquire multidrug resistance. This emphasizes the necessity for robust surveillance and monitoring of nontyphoidal Salmonella infections, particularly given the limited data on serovar Newport in India. Vigilance in clinical practice and public health initiatives is crucial to effectively address the emergence and spread of multidrug-resistant strains.
Epidemiology and genotypes analysis of human papillomavirus infection in Huizhou, China
Authors: Shu Zhun , Zhao Wenli , Zhan Xuebing , Zeng Jiaqi , Li Jingyi
Published: August 2024

Background

Human papillomavirus (HPV) is a main pathogenic factor for cervical carcinoma. The prevalence and genotypes distribution of HPV vary in different regions. Thus, our study aimed to investigate the epidemiology of HPV in Huizhou, China.

Methods

HPV tests were detected in 5,325 female outpatients, we focused on the overall HPV prevalence, genotypes distribution, and the correlation of HPV genotypes with cervical cytology.

Results

The overall HPV prevalence was 27.53%, HPV52, HPV58, HPV39, HPV16 and HPV51 were predominant genotypes with single infection rate of 70.80%. HPV infection rate showed a U-shaped age distribution, statistical differences were observed among 5 age groups (χ2 = 50.497, p < 0.01), and the higher positive rate was aged under 30 (34.42%) and above 60 (34.74%). Among high-risk HPV (hrHPV) infections, 60.69% involved NILM, 0.99% HSIL. The degrees of cervical lesions in multiple hrHPV infections were worse than those in single infection (p < 0.01).

Conclusion

The HPV infection rate is high in Huizhou, Guangdong, single infection was predominant. HPV infection presented with a U-shaped age distribution. Multiple hrHPV infection was worrying since it may aggravate cervical lesions. Women should pay more attention to HPV detection and choose a more appropriate HPV vaccine according to local HPV type distribution.
A feasibility randomized controlled trial of a community-level physical activity strategy for older adults with motoric cognitive risk syndrome
Authors: Hernon Shannon M. , Singh Yashi , Ward Nathan , Kramer Arthur F. , Travison Thomas G. , Verghese Joe , Fielding Roger A. , Kowaleski Christopher , Reid Kieran F.
Published: August 2024

The motoric cognitive risk syndrome (MCR) is a syndrome characterized by subjective memory complaints and slow walking speeds that can identify older adults at increased risk for developing Alzheimer’s disease or a related dementia (ADRD). To date, the feasibility of community-based physical activity (PA) programs for improving outcomes in MCR have yet to be examined. To address this knowledge gap, we conducted a translational randomized controlled trial (RCT) comparing 24-weeks of PA to a healthy aging education (HE) control intervention delivered within the infrastructure of an urban senior center in Greater Boston (clincaltrials.gov identifier: NCT03750682). An existing senior center employee was trained to administer the multimodal group-based PA program that included moderate-intensity aerobic walking, strength, flexibility and balance training. A total of 79 older adults attended the senior center for a screening visit, of whom 29 met the MCR criteria and 25 were randomized to PA or HE (mean age: 74.4 ± 7 years; BMI: 32.4 ± 7 kg/m2; 85% female; 3MSE score: 92.4 ± 7; gait speed: 0.52 ± 0.1 m/s; SPPB score 4.8 ± 1.9). Due to the Covid-19 pandemic the study was stopped prematurely. Participants could successfully adhere to the study interventions (overall attendance rate: PA: 69% vs. HE:70% at study termination). Participants also successfully completed baseline and follow-up study assessments that included a computerized cognitive testing battery and objective tests of physical performance and functional exercise capacity. No study-related adverse events occurred. Notable trends for improved cognitive performance, gait speed and 6-min walk distance were exhibited in PA compared to HE. Our study provides important preliminary information to aid the design of larger-scale RCTs of PA that may help to preserve the independence of vulnerable older adults at high risk for ADRD in community-based settings.
Enhancing educational Q&A systems using a Chaotic Fuzzy Logic-Augmented large language model
Authors: Chen Haoyuan , Shi Nuobei , Chen Ling , Lee Raymond
Published: August 2024

Introduction

Online question-and-answer (Q&A) platforms are frequently replete with extensive human resource support. This study proposes a novel methodology of a customized large language model (LLM) called Chaotic LLM-based Educational Q&A System (CHAQS) to navigate the complexities associated with intelligent Q&A systems for the educational sector.

Methods

It uses an expansive dataset comprising over 383,000 educational data pairs, an intricate fine-tuning process encompassing p-tuning v2, low-rank adaptation (LRA), and strategies for parameter freezing at an open-source large language model ChatGLM as a baseline model. In addition, Fuzzy Logic is implemented to regulate parameters and the system's adaptability with the Lee Oscillator to refine the model's response variability and precision.

Results

Experiment results showed a 5.12% improvement in precision score, an 11% increase in recall metric, and an 8% improvement in the F1 score as compared to other models.

Discussion

These results suggest that the CHAQS methodology significantly enhances the performance of educational Q&A systems, demonstrating the effectiveness of combining advanced tuning techniques and fuzzy logic for improved model precision and adaptability.
Predictive multiuser redirected walking using artificial potential fields
Authors: Hirt Christian , Isaak Noah , Holz Christian , Kunz Andreas
Published: August 2024

Real walking is considered as the best locomotion metaphor to explore virtual environments in terms of user experience. In addition to being intuitive for the user, walking captures the true feelings of motion since the visual and proprioceptive sensations are harmonized well. The major disadvantage of choosing walking over other locomotion metaphors involves the physical constraints of the available space, which is usually considerably smaller than the virtual environment. To address this issue, redirected walking (RDW) introduces slight mismatches between a user’s visually perceived path and their actual walking pattern, compelling them to subconsciously compensate for the inconsistency by adjusting their walking trajectory. As a result, users are steered to a certain degree, and expansive virtual environments are effectively compressed into smaller physical spaces. Among others, particularly predictive RDW offers immense potential for growth since it unites various algorithmic systems, whereas many approaches from literature depend on drastic restrictions like single-user constraints or architectural limitations to ensure real-time performance. This work presents two novel predictive RDW systems that allow multiple physically colocated users to explore independent and unconstrained virtual environments. The systems rely on two new implementations of prediction systems based on clothoid trajectory generation combined with a cost-based planning concept built on non-harmonic artificial potential fields (APFs), which inherently allow non-convex and dynamic physical environments. Using the APFs, three additional RDW conditions popular in the literature are implemented for comparison purposes. The five RDW concepts are then validated in an extensive user study with 150 participants conducted in 75 pairs. The results indicate that the novel predictive RDW systems outperform the three systems from literature, except for particular sections of the virtual environment with specific architectural traits.
What Can The Eyes Tell Us About Schizophrenia?
Authors: O’Leary Shelby , Hout Michael C.
Published: August 2024

Have you ever had an imaginary friend? If you ever have, you probably did not physically see or hear them outside of your imagination. Unfortunately, some people see and hear things that are not actually real. This can be a feature of a mental disorder known as schizophrenia. There is much scientific interest in studying mental health, and scientists have many tools at their disposal to investigate disorders like schizophrenia. One of the ways psychologists study how the brain works is by using an eye-tracker—a device that has a camera and a computer and can determine where a person is looking. People diagnosed with schizophrenia often show unusual patterns of eye movements that give scientists clues about how the disorder works and affects patients. This information also gives medical professionals a valuable tool by which to diagnose their patients.
Virtual Reality: A Game Changer for Children’s Medical Procedures
Authors: Mounsef Peter Joseph , Addab Sofia , Hamdy Reggie , Le May Sylvie , Thorstad Kelly , Tsimicalis Argerie
Published: August 2024

Going to the hospital can be scary for children, especially when they must go through a painful procedure. Doctors, nurses, and other health professionals may use special distraction techniques to help take children’s minds off the pain. There is a cool new way to help distract children from painful procedures. It is called virtual reality (VR). A study was done at a children’s hospital that specializes in bone care. The researchers wanted to know if VR was easy to use at the hospital to help the children deal with pain. The study included 44 children who had different kinds of procedures done, like having a needle put in their vein, removing stitches, having blood taken, and more. The researchers concluded that VR can help. VR is fast and easy to use, almost everyone liked it, and it works. To help with pain relief, virtual reality has all the ingredients to be a recipe for success!
Study on the impact of climate risk on the agricultural insurance purchasing behavior of herding households—an empirical analysis based on Inner Mongolia
Authors: Chen Xiao-long , Zhao Yuan-feng
Published: August 2024

The analysis of herding households’ agricultural insurance purchasing behavior under climate risk can help improve the agricultural insurance system in pastoral areas in China.By constructing an analytical framework of “climate change, risk perception, and herding households’ agricultural insurance purchase decisions,” this study matched the survey data from 764 herding households across different types of grasslands in Inner Mongolia with meteorological data from 2019 to 2023. Based on Probit model regression and mediation effect tests, the following conclusions were drawn: Firstly, climate change, especially abnormal fluctuations in precipitation, triggers yield losses and induces loss aversion among herding households, which translates into agricultural insurance purchasing behavior. Secondly, as herding households are divided into production herding households and subsistence herding households, the impact of climate risk on production herding households’ agricultural insurance purchase decisions is more pronounced than that of subsistence herding households. Thirdly, from the perspective of the mechanism of climate change on the agricultural insurance purchasing behavior of production-oriented herding households, climate risk mainly influences herding households’ agricultural insurance purchase through their risk perception. Therefore, with the intensification of global climate change, while further stimulating the agricultural insurance purchasing demand of living herding households through differentiated premium subsidy policies in the future, it is necessary to further enhance the risk perception level of herding households by strengthening the construction of weather forecasting and agricultural and livestock risk data sharing platform, so as to transform the external changes in climate risk into the intrinsic motivation of herding households’ agricultural insurance purchasing behaviors, and to enhance the herding households’ Climate risk coping capacity of herdsmen.
The impact of land consolidation on farmer income: evidence from high-standard farmland construction in China
Authors: Chen Xiaoxuan , Xue Zhou , Han Guoying , Gao Qiang
Published: August 2024

Land consolidation has become an organized and widely implemented project in rural areas. However, research remains somewhat scarce on the contributing mechanism of land consolidation to farmer income in developing countries. Using provincial panel data from China, this study employs a fixed effects model to analyze the influence of high-standard farmland construction on farmer income and underlying mechanisms. Results suggest that the implementation of high-standard farmland construction can significantly augment farmer income. Reduction in agricultural production cost, improvement in agricultural management benefit and increase in non-farm income have led to the boost in income. The relationship between income and high-standard farmland construction exhibits regional disparities, with the most significant impacts concentrated in economically developed areas and low relief degree areas. Our findings suggest that it is imperative for the Chinese government to persistently promote the establishment of high-standard farmland, and further enhance its positive influence on advancing agricultural cost-effectiveness and expanding non-farm income channels for farmers.