bluuebunny/crossref_metadata_2025 huggingface dataset:
Network Pharmacology and Experimental Validation to Elucidate the Pharmacological Mechanisms of Luteolin Against Chondrocyte Senescence
Authors: Long Ling , Tang Xiaokai , Wang Yi , Gu Jiaxiang , Xiong Jiachao , Luo Hao , Lv Hao , Zhou Faxin , Cao Kai , Lin Sijian
Published: February 2024

Background:

Luteolin, a flavonoid found in various medicinal plants, has shown
promising antioxidant, anti-inflammatory, and anti-aging properties. The cartilaginous endplate
(CEP) represents a crucial constituent of the intervertebral disc (IVD), assuming a pivotal responsibility
in upholding both the structural and functional stability of the IVD.

Objective:

Exploring the precise mechanism underlying the protective effects of luteolin against
senescence and degeneration of endplate chondrocytes (EPCs).

Methods:

Relevant targets associated with luteolin and aging were obtained from publicly available
databases. To ascertain cellular functions and signaling pathways, Gene Ontology (GO) and
Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were employed. Core genes were
identified through the construction of a protein-protein interaction (PPI) network. Molecular
docking (MD) was utilized to assess the binding affinity of luteolin to these core genes. Finally,
the impact of luteolin on the senescence and degeneration of EPCs was evaluated in an in vitro
cellular senescence model induced by tert-butyl hydroperoxide (TBHP).

Results:

There are 145 overlapping targets between luteolin and senescence. Analysis using GO
revealed that these targets primarily participate in cellular response to oxidative stress and reactive
oxygen species. KEGG analysis demonstrated that these markers mainly associate with signaling
pathways such as p53 and PI3K-Akt. MD simulations exhibited luteolin’s binding affinity
to P53, Cyclin-dependent kinase (CDK)2, and CDK4. Cell cycle, cell proliferation, and β-
galactosidase assays confirmed that luteolin mitigated senescence in SW1353 cells. Western blot
assays exhibited that luteolin significantly suppressed the expression of Matrix Metallopeptidase
(MMP) 13, P53, and P21, while concurrently promoting CDK2, CDK4, and Collagen Type II
Alpha 1 (COL2A1) expression.

Conclusion:

In summary, luteolin demonstrated beneficial properties against aging and degeneration
in EPCs, offering novel insights to mitigate the progression of intervertebral disc degeneration
(IVDD).
Disulfidptosis and its Role in Peripheral Blood Immune Cells after a Stroke: A New Frontier in Stroke Pathogenesis
Authors: Liu Shan-peng , Liu Cuiying , Xu Baohui , Zhou Hongmei , Zhao Heng
Published: February 2024

Background:

Stroke-Induced Immunodepression (SIID) is characterized by apoptosis
in blood immune populations, such as T cells, B cells, NK cells, and monocytes, leading to the
clinical presentation of lymphopenia. Disulfidptosis is a novel form of programmed cell death
characterized by accumulating disulfide bonds in the cytoplasm, resulting in cellular dysfunction
and eventual cell death.

Objective:

In this study, we investigated the association between disulfidptosis and stroke by
analyzing gene sequencing data from peripheral blood samples of stroke patients.

Methods:

Differential gene expression analysis identified a set of disulfidptosis-related genes
(DRGs) significantly associated with stroke. Initial exploration identified 32 DRGs and their
interactions. Our study encompassed several analyses to understand the molecular mechanisms
of DRGs in stroke. Weighted Gene Co-Expression Network Analysis (WGCNA) uncovered
modules of co-expressed genes in stroke samples, and differentially expressed gene (DEG) analysis
highlighted 1643 key genes.

Results:

These analyses converged on four hub genes of DRGs (SLC2A3, SLC2A14, SLC7A11,
NCKAP1) associated with stroke. Immune cell composition analysis indicated positive correlations
between hub genes and macrophages M1, M2, and neutrophils and negative associations
with CD4+ and CD8+ T cells, B cells, and NK cells. Sub-cluster analysis revealed two distinct
clusters with different immune cell expression profiles. Gene Set Enrichment Analysis (GSEA)
demonstrated enrichment of apoptosis-related pathways, neurotrophin signaling, and actin cytoskeleton
regulation. Associations between hub genes and apoptosis, necroptosis, ferroptosis, and
cuproptosis, were also identified.

Conclusion:

These results suggest that the DRG hub genes are interconnected with various cell
death pathways and immune processes, potentially contributing to stroke pathological development.
Follow-up Comparisons of Two Plasma Biomarkers of Alzheimer’s
Disease, Neurofilament Light Chain, and Oligomeric Aβ: A Pilot Study
Authors: Shim YongSoo
Published: February 2024

Background and Objective:

Recent evidence suggests that blood-based biomarkers
might be useful for Alzheimer’s disease (AD). Among them, we intend to investigate whether neurofilament
light (NfL) and multimer detection system-oligomeric Aβ (MDS-OAβ) values can be
useful in screening, predicting, and monitoring disease progression and how the relationship between
NfL and MDS-OAβ values changes.

Methods:

Eighty participants with probable AD dementia, 50 with mild cognitive impairment
(MCI), and 19 with subjective cognitive decline (SCD) underwent baseline and follow-up evaluations
of the Mini-Mental Status Examination (MMSE) and both plasma biomarkers.

Results:

Baseline MDS-OAß (p=0.016) and NfL (p=0.002) plasma concentrations differed significantly
among groups, but only NfL correlated with baseline MMSE scores (r=-0.278, p=0.001). In
follow-up, neither correlated with MMSE changes overall. However, in SCD and MCI participants
(n=32), baseline MDS-OAß correlated with follow-up MMSE scores (r=0.532, p=0.041). Linear
regression revealed a relationship between baseline MDS-OAβ and follow-up MMSE scores. In
SCD and MCI participants, plasma NfL changes correlated with MMSE changes (r=0.564,
p=0.028).

Conclusion:

This study shows that only in participants with SCD and MCI, not including AD dementia,
can MDS-OAß predict the longitudinal cognitive decline measured by follow-up MMSE.
Changes of NfL, not MDS-OAß, parallel the changes of MMSE. Further studies with larger samples
and longer durations could strengthen these results.
Neuronatin Promotes the Progression of Non-small Cell Lung Cancer by
Activating the NF-κB Signaling
Authors: Xiong Huanwen , Chen Guohua , Fang Ke , Gu Weiguo , Qiu Feng
Published: February 2024

Background and Objective:

Understanding the regulatory mechanisms involving neuronatin
(NNAT) in non-small cell lung cancer (NSCLC) is an ongoing challenge. This study aimed
to elucidate the impact of NNAT knockdown on NSCLC by employing both in vitro and in vivo approaches.

Methods:

To investigate the role of NNAT, its expression was silenced in NSCLC cell lines A549
and H226. Subsequently, various parameters, including cell proliferation, invasion, migration, and
apoptosis, were assessed. Additionally, cell-derived xenograft models were established to evaluate
the effect of NNAT knockdown on tumor growth. The expression of key molecules, including cyclin
D1, B-cell leukemia/lymphoma 2 (Bcl-2), p65, matrix metalloproteinase (MMP) 2, and nerve
growth factor (NGF) were examined both in vitro and in vivo. Nerve fiber density within tumor tissues
was analyzed using silver staining.

Results:

Upon NNAT knockdown, a remarkable reduction in NSCLC cell proliferation, invasion,
and migration was observed, accompanied by elevated levels of apoptosis. Furthermore, the expression
of cyclin D1, Bcl-2, MMP2, and phosphorylated p65 (p-p65) showed significant downregulation.
In vivo, NNAT knockdown led to substantial inhibition of tumor growth and a concurrent
decrease in cyclinD1, Bcl-2, MMP2, and p-p65 expression within tumor tissues. Importantly,
NNAT knockdown also led to a decrease in nerve fiber density and downregulation of NGF expression
within the xenograft tumor tissues.

Conclusion:

Collectively, these findings suggest that neuronatin plays a pivotal role in driving NSCLC
progression, potentially through the activation of the nuclear factor-kappa B signaling cascade.
Additionally, neuronatin may contribute to the modulation of tumor microenvironment innervation
in NSCLC. Targeting neuronatin inhibition emerges as a promising strategy for potential
anti-NSCLC therapeutic intervention.
Curcumin Inhibits Vasculogenic Mimicry via Regulating ETS-1 in Renal
Cell Carcinoma
Authors: Chong Yue , Xu Shan , Liu Tianjie , Guo Peng , Wang Xinyang , He Dalin , Zhu Guodong
Published: February 2024

Background:

Metastatic renal cell carcinoma (RCC) poses a huge challenge once it has
become resistant to targeted therapy. Vasculogenic mimicry (VM) is a novel blood supply system
formed by tumor cells that can circumvent molecular targeted therapies. As one of the herbal remedies,
curcumin has been demonstrated to play antineoplastic effects in many different types of human
cancers; however, its function and mechanism of targeting VM in RCC remains unknown.

Objective:

Here, in the work, we explored the role of curcumin and its molecular mechanism in
the regulation of VM formation in RCC.

Methods:

RNA-sequencing analysis, immunoblotting, and immunohistochemistry were used to detect
E Twenty Six-1(ETS-1), vascular endothelial Cadherin (VE-Cadherin), and matrix metallopeptidase
9 (MMP9) expressions in RCC cells and tissues. RNA sequencing was used to screen
the differential expressed genes. Plasmid transfections were used to transiently knock down or
overexpress ETS-1. VM formation was determined by tube formation assay and animal experiments.
CD31-PAS double staining was used to label the VM channels in patients and xenograft
samples.

Results:

Our results demonstrated that VM was positively correlated with RCC grades and stages
using clinical patient samples. Curcumin inhibited VM formation in dose and time-dependent manner
in vitro. Using RNA-sequencing analysis, we discovered ETS-1 as a potential transcriptional
factor regulating VM formation. Knocking down or overexpression of ETS-1 decreased or increased
the VM formation, respectively and regulated the expression of VE-Cadherin and MMP9.
Curcumin could inhibit VM formation by suppressing ETS-1, VE-Cadherin, and MMP9 expression
both in vitro and in vivo.

Conclusion:

Our finding might indicate that curcumin could inhibit VM by regulating ETS-1,
VE-Cadherin, and MMP9 expression in RCC cell lines. Curcumin could be considered as a potential
anti-cancer compound by inhibiting VM in RCC progression.
Treatment of Reactive Orange 16 Dye-Bearing Wastewater by
Electro-Fenton Process with Stainless-Steel Electrodes: Statistical
Optimization and Operational Analysis
Authors: Ahmad Imran , Basu Debolina
Published: February 2024

In the current work, the Electro-Fenton (EF) based Reactive Orange 16 (RO16) dye treatment
was studied and compared with central composite (CC) and Taguchi design (TD) statistical
optimization tools. Color removal (RC) and COD decay (RCOD) were chosen responses for the effect
of pH (A), electrolysis time (B), initial dye concentration (C), and current density (D). The facecentred
CC design and L16 orthogonal array were used in the experimental procedures. At optimal
conditions, the coefficient of determination (R2) values of 0.99 for CC and 0.97 for TD suggest statistical
significance and good model agreement. The results of the ANOVA and Prob. > F values supported
the model’s successful experimental data fitting. Taguchi method was found as an appropriate
methodology for parameter percentage contributions with fewer experimental runs. Moreover, the S/N
ratio charts proved to be a successful CC design replacement. The current density and pH were found
to be the most important factors for the EF process. A higher biodegradability (BOD5/COD) and minimum
iron concentration (0.45 mg/L) in the effluent sludge demonstrated good environmental disposal
suitability. In the last, the effect of various inhibitors/scavengers (SO4
−2, PO4
−3, EDTA, etc.) on the
EF process performance was also carried out.
QSAR Analysis and Molecular Docking Studies of Aryl Sulfonamide Derivatives as Mcl-1 Inhibitors and the Influence of Structure and Chirality on the Inhibitory Activity
Authors: Chen Jia , Ma Yang , Zou Jian-Wei , Hu Sheng , Huang Meilan , Hu Guixiang
Published: February 2024

Background:

Mcl-1 is a kind of antiapoptotic protein and its overexpression is closely
related to the occurrence of cancer. Aryl sulfonamide derivatives are expected to become new anticancer
agents due to their high inhibitory activity on the Mcl-1 protein.

Objective:

The study aimed to establish the QSAR model with good prediction ability and elaborate
the influence of structure and chirality on the inhibitory activity.

Methods:

Multiple QSAR models were built with different types of descriptors and modeling methods.
The molecular docking was performed on compounds 45, 25, 26, 24R, and 24S. The MCCV
method was used to perform rigorous validations with up to 216
= 65,536 samplings for MLR, SVM,
LSSVM, RF, and GP methods based on the model of 2D and 3D combined descriptors.

Results:

The models based on 2D and 3D combined descriptors demonstrated non-linear LSSVM, RF, and GP methods based on the model of 2D and 3D combined descriptors. Results: The models based on 2D and 3D combined descriptors demonstrated non-linear LSSVM and GP methods to provide better results (R2>0.94, R2CV > 0.86). The predictive performances of MCCV tests have been basically coincident with the single test set’s results. The hydrogen bond acceptor at the appropriate position of the substituent on the chiral center could form the hydrogen bond interaction with residue ASN260, resulting in stronger interaction and higher inhibitory activity. The interaction differences between R and S configurations could be mainly attributed to two residues, HIS224 and ASN260. Furthermore, the steric effect of the substituent on chiral carbon atoms was crucial. A high steric effect could prevent the binding of the substituent and protein, resulting in low inhibitory activity.

Conclusion:

The study may provide theoretical guidance on the design and synthesis of novel aryl
sulfonamide derivatives with high inhibitory activity
Ultrasound-assisted Aqueous Two-Phase Extraction of Flavonoids from
Scutellariae Radix and Evaluation of their Bioactivities In Vitro
Authors: Ge Zhenkai , Zhao Yongheng , Ling Xu , Zhu Chenpan , Hao Xincai
Published: February 2024

Background:

Scutellariae Radix, one of the most widely used herbs in Traditional Chinese
Medicine, exhibits various biological activities due to its chemical components, which stand out
for a number of flavonoids. In this study, Ultrasound-assisted aqueous two-phase extraction (UAATPE)
was employed for the first time to obtain a high extraction rate and high purity of flavonoids
from Scutellariae Radix.

Methods:

The Box-Behnken response surface method (RSM) was utilized to optimize the extraction
conditions with the application of the new aqueous two-phase system (ATPS) composed of ethanol
and ammonium sulfate. The major influence factors, including ethanol concentration, ammonium
sulfate concentration, liquid-to-solid ratio, sonication time, and extraction temperature, were investigated
by the single-factor experiment. The compositional characterization of flavonoids was characterized
with HPLC-UV. Scanning electron microscopy (SEM) was applied to research the surface
morphology of raw material. Furthermore, the bioactivities of the extract obtained by UA-ATPE
were studied in vitro.

Results:

The optimal extraction conditions were as follows: the ethanol content was 26.12% (w/w),
the ammonium sulfate content was 20.02% (w/w), the liquid-to-solid ratio was 40 mL/g, the sonication
time was 5 min with the ultrasonic power of 250 W, and the operating process was performed
at room temperature. Compared with the traditional extraction methods, UA-ATPE exhibited higher
extraction efficiency and better extraction selectivity. The DPPH and ABTS radical scavenging tests
showed that enriched products possessed strong antioxidant activity.

Conclusion:

The study confirmed that the developed method of UA-ATPE could be used as an efficient,
eco-friendly, and low-consumption method for the extraction and purification of flavonoids
from Scutellariae Radix.
Preparation & Characterization of Sustained-release Floating Microsphere of Digestive Enzymes
Authors: Prajapati Bhupendra G. , Bhagat Anand , Basu Biswajit
Published: February 2024

Introduction:

Pepsin is a proteolytic enzyme which is widely used as a digestive aid. Its
dose is 300 mg - 1 gm per day in divided doses. Its biological half-life is around 3.5 hrs. Pepsin is
active only in the acidic pH of the stomach; its activity decreases tremendously in the basic pH. So,
it is required to retain in the stomach for maximum proteolytic activity. The goal of the current effort
is to develop and assess an oral controlled floating drug delivery system for pepsin that will shorten
its stay in the stomach and result in a longer effect.

Methods:

The 12-hour sustained effect of pepsin floating microspheres was planned. This also improves
the stability of the Pepsin by immobilizing them on the microsphere. Pepsin is widely used in
chronic gastritis, so developing a floating drug delivery system is therefore necessary. In light of the
aforementioned principles, a critical need for the creation of a dosage form to administer Pepsin in
the stomach and boost the enzyme's effectiveness, enabling sustained action, was identified. The current
study used a methodical strategy to create floating microspheres of Pepsin dosage forms.

Results:

Optimization was done for floating ability, yield, entrapment efficiency, and release study
using different concentrations of ethylcellulose & HPMC E4M. For parameter optimization and to
demonstrate the significant impact of variables, 32 full factorial designs were used. The manufactured
microspheres had good encapsulation rates, excellent floating, & excellent micromeritic properties as
single-unit dosage forms.

Conclusion:

It has been demonstrated that pepsin prepared as floating microspheres can be used to
improve proteolytic activity and extend pepsin's gastric residence.
From Pathophysiology to Personalized Treatment Strategies for Psoriasis
Authors: Barak Aashima , Sharma Anjali , Arora Deepshi , Mittal Vishnu , Gupta Akash , Grover Rohit
Published: February 2024

Background:

Psoriasis is a chronic inflammatory and proliferative skin disorder characterized
by redness and elevated patches covered in scaly, silvery-white skin. The National Psoriasis
Foundation categorizes psoriasis into mild, moderate, and severe, impacting 2% to 5% of the global
population. This article explores the types, development, and severity categories of psoriasis, delving
into its pathophysiology. It also reviews both conventional and herbal topical therapies and their marketed
formulations.

Aim:

The study aimed to contribute to the development of personalized treatment approaches for
individuals with psoriasis.

Objectives:

This article explores the types, development, and severity categories of psoriasis, delving
into its pathophysiology. It also reviews both conventional and herbal topical therapies and their marketed
formulations.

Methods:

The article relies on a comprehensive review of existing literature and research studies on
psoriasis. Information on types, severity categories, pathophysiology, and available treatments, both
conventional and herbal, is gathered and analyzed.

Results:

The results highlight the potential advantages of incorporating herbal therapies into treatment
plans for individuals with psoriasis, especially for those with severe cases.

Conclusion:

In conclusion, the article emphasizes the importance of individualized treatment plans
for managing psoriasis. Both conventional and herbal topical formulations can be viable options,
particularly for severe cases. By considering the safety profiles, side effects, and biological activities
associated with these treatments, healthcare experts can collaborate with patients to create personalized
and effective strategies for addressing the complexities of psoriasis management.
Interaction of Fe2O3 and Fe3O4 Nanoparticle with Pathogenic Bacteria:
A In-silico Molecular Mechanism Study
Authors: Luktuke Sahil , Raj Aditya , Santra Sourav , Das Sudip , Chakravorty Arghya , Ramesh Karthikeyan , Nila Balaji , K Harjeet , Sankar Sana Siva , Raghavan Vimala
Published: February 2024

Background::

Magnetic materials like iron, nickel, and cobalt have been a subject of
interest among the scientific and research community for centuries. Owing to their unique properties,
they are prevalent in the mechanical and electronic industries. In recent times, magnetic materials
have undeniable applications in biotechnology and nanomedicine. Bacteria like Salmonella enterica,
Clostridium botulinum, Bacillus subtilis, etc, pose a hazard to human health and livestock. This
ultimately leads to huge yields and economic losses on a global scale. Antimicrobial resistance has
become a significant public health concern in recent years, with the increasing prevalence of drugresistant
infections posing a significant threat to global health. Many coherent studies have
successfully reported magnetic metal oxide nanoparticles to be highly selective, specific, and
effective in neutralizing pathogens through various mechanisms like cell membrane disruption, direct
contact-mediated killing, or by generating Reactive Oxygen Species (ROS) and numerous costimulatory
and inflammatory cytokines. Therefore, we explored the inhibitory effects of iron oxide
nanoparticles (NPs) on various pathogenic bacteria via an in-silico approach. This method helped us
to understand the active sites where the iron oxide NPs bind with the bacterial proteins.

Methods::

The 3D crystal structures of all the pathogenic proteins of Streptococcus pneumoniae,
Pseudomonas aeruginosa, Vibrio cholerae, Salmonella enterica, Shigella flexneri, Clostridium
botulinum and nanoparticles (Fe2O3 and Fe3O4) under study were downloaded from RCSB PDB and
ChemSpider official websites respectively. It was followed by the in-silico molecular Docking using
PyRx and AutoDock Vina and analyzed on LigPlot.

Results::

This study interprets the efficacy of the Fe2O3 and Fe3O4 nanoparticles against all the test
bacteria. At the same time, Fe2O3 and Fe3O4 formed the most stable complexes with cholera
enterotoxin subunit B and lectin II (PA-IIL) mutant S23A of Pseudomonas aeruginosa, respectively.

Conclusion::

As in this era of AMR, researchers have been exploring alternative strategies to combat
bacterial infections, including using magnetic nanoparticles as a potential treatment. They possess
unique physical and chemical properties that make them attractive candidates for antimicrobial
therapy, including their ability to penetrate bacterial biofilms and selectively target pathogenic
bacteria while leaving healthy cells unharmed. This study examined the inhibitory effects of iron
oxide (magnetic) nanoparticles, namely Fe2O3 and Fe3O4, on various bacterial proteins involved in
cell-to-cell interactions and pathogenesis.
Berberine: A Multi-Target Natural PCSK9 Inhibitor with the Potential to
Treat Diabetes, Alzheimer’s, Cancer and Cardiovascular Disease
Authors: Coppinger Caroline , Pomales Briana , Movahed Mohammad Reza , Marefat Meredith , Hashemzadeh Mehrnoosh
Published: February 2024

Berberine is a natural product with a wide range of pharmacological effects. It has
antimicrobial, anti-cancer, anti-inflammatory, anti-hyperlipidemic, neuroprotective, and cholesterollowering
properties, among others. It has been used in traditional Chinese and Ayurvedic medicine
for 3000 years and is generally well-tolerated with few side effects. Its main drawback is low oral
bioavailability, which has hindered widespread clinical use. However, recent interest has surged
with the emergence of evidence that berberine is effective in treating cancer, diabetes, Alzheimer’s
disease, and cardiovascular disease via multiple mechanisms. It enhances insulin sensitivity and secretion
by pancreatic β-cells in Type 2 Diabetes Mellitus in addition to reducing pro-inflammatory
cytokines such as IL-6, IL-1β, TLR4 and TNF-α. These cytokines are elevated in Alzheimer’s disease,
cardiovascular disease, and diabetes. Reductions in pro-inflammatory cytokine levels are associated
with positive outcomes such as improved cognition, reduced cardiovascular events, and
improved glucose metabolism and insulin sensitivity. Berberine is a natural PCSK9 inhibitor, which
contributes to its hypolipidemic effects. It also increases low-density lipoprotein receptor
expression, reduces intestinal cholesterol absorption, and promotes cholesterol excretion from the
liver to the bile. This translates into a notable decrease in LDL cholesterol levels. High LDL
cholesterol levels are associated with increased cardiovascular disease risk. Novel synthetic berberine
derivatives are currently being developed that optimize LDL reduction, bioavailability, and other
pharmacokinetic properties.
Cinq échanges à la Une : Entretien avec Hédi Bouraoui sur le transculturalisme
Authors: Theriau Frédéric Gael
Published: February 2024

: This article is a slightly special because it draws directly from the source of one of the most recognized and titled Francophone personalities in English-speaking Canada. It is Hédi Bouraoui, whose migratory journey and writings about migrant literature date back to the appearance of Canadian multiculturalism, in which he and former Minister Pierre Elliott Trudeau personally took part. The federal policy of the latter, adopted in 1971, made Canada the first country of the world to have adopted multiculturalism. If the approach is honorable, Hédi Bouraoui recognizes however some excesses and tries to propose its close variant through the notion of “transculturalism”. The man being very old to this day, I felt that it was perhaps better to present his speech through the interview I had with him during several sessions ((Tours-Toronto, from January to March 2023) rather than to present an academic and theoretical communication..
CARDIAC BIOMETRICS AND PERCEIVED WORKLOAD REGRESSION ANALYSIS USING RANDOM FOREST REGRESSOR IN COGNITIVE MANUFACTURING TASKS
Authors: Harmayanti Afifah , Tama Ishardita Pambudi , Gapsari Femiana , Akbar Zuardin , Juliano Hans
Published: February 2024

Workload is crucial in managing and maintaining good performance of human resources and allocations. In an advanced manufacturing industry, human job functions had shifted to cognitive tasks. Thus, cognitive workload evaluation should be used to monitor worker’s workload in optimal condition. Most common tool of cognitive workload tools are perceived measurement, like NASA – TLX questionnaire. Despite of its sensitivity to capture workload felt by the workers, this subjective measurement was prone to bias. Objective measurement utilizing biometrics data of the human body during working state was useful to eliminate bias. Cardiac biometrics were one of the many that were closely related to mental activity changes. The objective of this study was to understand the relationship of cardiac biometrics to perceived workload as an indicator of cognitive workload analysis. The study utilized four biometrics, heart rate, HRV low frequency power, total frequency power and ratio of low and high frequency power, were used to analyzed a one hour long cognitive based study case. The study case was designed in a manufacturing planning context referring to manufacturing aptitude tests, to induce cognition process on 30 participants. The biometrics and NASA – TLX score result of all the participants, were then calculated as effect size standardization before input into random forest regressor model to analyze relationship between cardiac biometrics and perceived workload. The result found a moderate relationship between the two (r2 = 0.576). Features importance also showed the most impactful feature to the model is the effect size of frequency power ratio. However, it is recommended to always consider evaluating multiple cardiac biometrics in workload analysis to ensure good model performance.
Sicad: Smart Information System For Village Administration As An Empowering Ngadiluwih Village Kediri In Improving Community Services
Authors:   Department of Statistics, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Astuti Ani Budi
Published: February 2024

he Ngadiluwih Village Government, Kediri Regency, East Java Province also really needs an Android-based application so that the reach of access is wide in an effort to digitize villages to improve village administration services online. The purpose of this community service activity is to build and develop the Ngadiluwih Village Government Smart Information System application, which is abbreviated as Ngadiluwih SICAD in the context of empowering Ngadiluwih Village in an effort to improve online village administration services to the community. The socialization, implementation, and assistance were also carried out to village officials and the community regarding the Ngadiluwih SICAD application product. The results of this activity show that the Ngadiluwih SICAD that has been built is in accordance with the expectations and needs of Ngadiluwih Village and the community with 14 types of letter facilities.
Application of packaging technology to improve the quality of strawberry milk in Tulungrejo Village, Batu.
Authors:   Fakultas Teknologi Pertanian, Universitas Brawijaya, Sugiarto Yusron
Published: February 2024

This program targets unproductive Micro, Small and Medium-sized Enterprises (MSMEs) farmer groups in Dusun Wonorejo, Desa Tulungrejo, Kecamatan Bumiaji. The program deals with problems related to the cultivation of strawberries, the production of strawberry jelly drinks, and business permits. The activities during the community services were 1) the assistance for strawberry farmers to enhance the cultivation of strawberries; 2) the socialization activities related to product strengthening by packaging technology; and 3) the guidance on obtaining business permits. This community service implemented an integrated approach to enhance the creativity and knowledge of strawberry farmer groups to increase the economic value of processed strawberry products. The community service activities provided strawberry plant seedlings for rejuvenation, enabling partners to independently manage and develop strawberry-picking tourism. During socialization activities, the farmer gains an understanding of the necessary business permits. Any spelling, grammar, and punctuation errors have been corrected. Furthermore, the socialization of packaging helped farmers to improve packaging to enhance product quality.
Management of the Semeru Biosphere Reserve Area to Improve the Tourism Sector in Poncokusumo District
Authors:   Fakultas Teknologi Pertanian, Universitas Brawijaya, Nurika Irnia
Published: February 2024

Kawasan Bromo Tengger Semeru Arjuno merupakan salah satu cagar biosfer di Indonesia yang berada di Jawa Timur. Cagar biosfer Bromo Tengger Semeru Arjuno dikenal sebagai “Exotic Nature of Ancient Java” yang menggambarkan harmonisasi dalam pengelolaan kawasan dengan unsur manusia, budaya dan religi didalamnya. Kecamatan Poncokusumo berada disekitar kawasan tersebut sebagai zona penunjang dan transisi, dimana wilayahnya berpotensi dalam agropolitan dan pariwisata. Salah satu desa di Kecamatan Poncokusumo, Desa Gubuklakah, berada dalam kawasan destinasi wisata seperti Coban Pelangi, Coban Bidadari, dan Gunung Sari Sunset. Pengembangan dan penanganan Desa Gubuklakah dinilai perlu dilakukan untuk meningkatkan kesejahteraan masyarakat dengan melihat adanya potensi pengembangan agrowisata. Program Doktor Mengabdi (DM) ini dilaksanakan dengan kegiatan Kuliah Kerja Nyata (KKN) untuk memberikan solusi pembangunan sektor potensial di wilayah zona penunjang Kawasan Cagar Biosfer Semeru.
Application of Retort Pouch Sterilization Technology to DD Satoe Packaged Chili Sauce Surabaya
Authors:   Departemen Ilmu Pangan dan Bioteknologi, Fakultas Teknologi Pertanian, UniversitasBrawijaya, Ali Dego  Yusa
Published: February 2024

People in Indonesia are usually consuming commercial packaged of home-made chili sauce, which is mostly produced by MSMEs. UD Dede Satoe produce chili sauce using preservation techniques with aseptic packaging. The weakness of this technique is that aseptic conditions are not fully adequate for preservation. Nowadays, people awareness to health and food safety are increasing. To meet market demand for packaged chili products without preservatives addition, UD DD Satoe is trying to change the process from aseptic packaging to sterilizing packaged chili sauce using retort technology. The evaluation results show that retort pouch sambal can last for 1 year without the addition of preservatives. This result was proven to be better than the preservation method of making semi-dry packaged chili sauce, because it can maintain the color, taste and texture of the chili sauce.
A CONTINGENCY APPROACH TO PUBLIC SECTOR PERFORMANCE MANAGEMENT: THE CASE OF THE CANADIAN INTELLIGENCE COMMUNITY
Authors: Faragone Joe
Published: February 2024

On November 13, 2023, Dr. Joe Faragone presented A Contingency Approach to Public Sector Performance Management: The Case of the Canadian Intelligence Community for this year’s West Coast Security Conference. The presentation was followed by a question-and-answer period with questions from the audience and CASIS Vancouver executives. The key points discussed were the limitations of universalistic performance management approaches, the critical need to reassess NPM reforms in Public Administration, and the necessity to explicitly define the distinctiveness of the Intelligence Community.

 

Received: 12-11-2023

Revised: 01-26-2024
WHAT SHOULD INTELLIGENCE PRIORITIES BE GIVEN THE STATE OF HEGEMONIC INSTABILITY?
Authors: Johnson Loch K.
Published: February 2024

On November 15, 2023, Dr. Loch K. Johnson, Regents Professor Emeritus of Public and International Affairs at the University of Georgia, presented What Should Intelligence Priorities Be Given The State of Hegemonic Instability? for this year’s West Coast Security Conference. The presentation was followed by a question-and-answer period with questions from the audience and CASIS Vancouver executives. The key points discussed were the history of US intelligence prioritization, the need for increased attention towards universal threats, and the need for open societies to share intelligence tasking and findings with each other.

 

Received: 01-12-2024

Revised: 01-26-2024
ROYAL CANADIAN NAVY STRATEGY IN THE ARCTIC - CHALLENGES AND OPPORTUNITIES
Authors: Layton Doug
Published: February 2024

On November 15, 2023, Captain Doug Layton, Deputy Commander Joint Task Force (North), Canadian Armed Forces (Navy), presented Royal Canadian Navy Strategy in the Arctic: Challenges and Opportunities for this year’s West Coast Security Conference. The presentation was followed by a question-and-answer period with questions from the audience and CASIS Vancouver executives. The key points discussed were the effects of climate change in the Arctic Region, the Canadian Armed Forces' roles and policies in the North and the Royal Canadian Navy’s Arctic objectives.

 

Received: 01-04-2024

Revised: 01-26-2024
2023 WEST COAST SECURITY CONFERENCE WELCOMING REMARKS DAY 3
Authors: Pyrik John
Published: February 2024

On November 15, 2023, Mr. John Pyrik presented the opening address for this year’s West Coast Security Conference. The key points discussed were the introduction of speakers for the international perspectives panel of the CASIS conference and their contribution to the field of intelligence. 

Received: 01-04-2024

Revised: 01-26-2024
CONSIDERATIONS FOR UPDATING THE CONTEMPORARY INTELLIGENCE CYCLE TO THE CONTEMPORARY ENVIRONMENT
Authors: Kelshall Candyce
Published: February 2024

On November 17, 2023, Professor Candyce Kelshall presented Considerations for Updating the Contemporary Intelligence Cycle to the Contemporary Environment for this year’s West Coast Security Conference. The presentation was followed by a question-and-answer period with questions from the audience and CASIS Vancouver executives. The key points discussed were the importance of an effective Intelligence Cycle, the main issues with the Intelligence Cycle, and the new proposed Review Centric Cycle.

 

Received: 01-04-2024

Revised: 01-20-2024
2023 WEST COAST SECURITY CONFERENCE WELCOMING REMARKS DAY 5
Authors: Pyrik John , Deisman Wade
Published: February 2024

On November 17, 2023, Mr. John Pyrik and Dr. Wade Deisman presented the opening address for the fifth day of this year’s West Coast Security Conference. The speakers provided insights into the intelligence and security community informed by their backgrounds and expertise in analytic methodologies, intelligence theory and applications, and policing and security. They discussed the benefit of collaborative events and programs in advancing intelligence education in Canada and noted key initiatives being pursued by the Justice Institute of British Columbia in the coming year.

 

Received: 01-20-2024

Revised: 01-29-2024
Traducciones inéditas de Sófocles al castellano en el siglo XIX
Authors: González Delgado Ramiro
Published: February 2024

Sófocles no contará con la versión española de sus siete tragedias conservadas hasta que la colección “Biblioteca Clásica” de la editorial Hernando la publica en versión de José Alemany Bolufer en 1921. Antes del siglo XIX solo podemos considerar traducción Edipo Tirano de Pedro Estala (1793). En el siglo XIX se publicaron en España tan solo tres obras del trágico griego: Edipo Rey (1878), vertida por Enric Franco al catalán; y, al castellano, Antígona (1883), por Antonio González Garbín, y Filoctetes (1886), por Ángel Lasso de la Vega. Tres tragedias vertidas por Pedro Montegón a finales del siglo XIX, conservadas en un manuscrito de la Real Academia de la Historia, dejarán de estar inéditas a finales del siglo XX (1992) con su publicación en Italia: Edipo Rey, Electra y Filoctetes. Finalmente, todavía se encuentran manuscritas en la Biblioteca Menéndez Pelayo de Santander tres tragedias sofocleas: Antigone, traducida por Graciliano Afonso; Edipo en Colona, por Emeterio Suaña y Castellet; y Ayante, con dos versiones (prosa y verso) por José Musso y Valiente. El objetivo de este artículo es presentar y comentar estos textos que nos proponemos recuperar en breve.
Autoras inglesas publicadas durante el Franquismo. Jane Austen, Mary Shelley, Charlotte Brontë, George Eliot y Anne Brontë
Authors: Riba Caterina , Sanmartí Carme
Published: February 2024

Este artículo analiza la recepción de cinco autoras inglesas del siglo xix, Jane Austen, Mary Shelley, Charlotte Brontë, George Eliot y Anne Brontë, traducidas al español y publicadas en España durante la época franquista. El estudio se centra en las diez novelas de estas escritoras que superaron la rigurosa censura administrativa y se publicaron por primera vez entre 1939 y 1975: Sense and Sensibility, Mansfield Park y Emma de Jane Austen; The Professor, Shirley y Villette de Charlotte Brontë; Agnes Grey y The Tenant of Wildfell Hall de Anne Brontë; Janet’s Repentance de George Eliot, y Frankenstein de Mary Shelley. Para elucidar los motivos que llevaron a la censura a autorizar la publicación de estas autoras de tradición protestante, se han examinado todos los expedientes de censura referentes a los libros tratados (49 expedientes) y se han tenido en cuenta las valoraciones de los catálogos morales que circulaban durante el franquismo. También se ha llevado a cabo un análisis comparativo en traducciones para verificar si se produjeron transformaciones significativas en el proceso de traducción. La censura fue muy laxa con las autoras analizadas y las novelas se publicaron sin muchos reparos.
Paratexts as mediators of translations. The case of the preface to a Portuguese version of Defoe’s Robinson Crusoe
Authors: Gândara Terenas Gabriela
Published: February 2024

The provision of a translator’s paratext offers greater visibility to the translator and a direct source of information on his/her decisions and intentions. Osório de Oliveira, the translator of the Portuguese version of Defoe’s Robinson Crusoe, replaces the author’s original preface with one of his own in which he justifies the alterations to the original text, whilst underlining that it was a Portuguese vessel on its way to Brazil which saved the hero from his desperate plight. This paper proposes to examine the reasons for Oliveira’s emphasis on this particular episode, to the detriment of others which were unquestionably more interesting within the context of the hero’s adventures. The date of publication of the translation – 1940 – and consequently of the paratext, provides the principal key to the answer, as the ideology of the Estado Novo was founded on the exaltation of the Portuguese “Discoveries”, underpinning a colonial policy which supposedly justified the retention of the “Overseas Provinces”. The paper discusses the translator’s reasons for intervening in the target text, whilst attempting to evaluate how far the paratext may have mediated the reception of a final version in which the deeds of past heroes were exploited in an attempt to appropriate Defoe’s story.
El asesinato y la traducción consideradas como dos Bellas Artes
Authors: Zarandona Juan Miguel
Published: February 2024

Thomas de Quincey (1785–1859) fue un escritor inglés de principios del siglo xix y genio del humor más provocador que el brillante romanticismo de su nación ha ofrecido a la República Universal de las Letras. En español, sus dos libritos más escandalosos, por ser los más populares, recibieron los títulos siguientes: Los Placeres y las Tormentas del Opio, del original de 1821 (Confessions of an English Opium Eater), y El Asesinato, Considerado Como Una de las Bellas Artes, del original de 1832 (On Murder Considered as One of the Fine Arts). Si el asesinato en las Islas Británicas podría considerarse una de las bellas artes, como años más tarde tal vez terminara de demostrar su paisana y sucesora Dame Agatha Christie (1890–1976), cómo no utilizar la misma metáfora para las traducciones españolas: la recepción del humor y de los dobles sentidos, la crítica social, el enfoque estético-revolucionario de la empresa libresca que se encuentra entre sus manos, la manipulación de las normas de traducción, intenciones y hasta leyes de traducción, el cambio de funciones, etc. Tal vez no sea posible rebuscar entre un texto más acertado que el que proponemos para este artículo, para descubrir una vez más que ciertas traducciones, al menos, son un producto artístico, aunque la traducción perfecta no exista, como, según dicen algunos, el crimen perfecto tampoco, por muy bello y macabro que sea este.
Across languages, across media. A comparative analysis of linguistic variation in literary translation and transmedial adaptation of a Chinese-American fictional character
Authors: Renna Dora , Santulli Francesca
Published: February 2024

This study explores translation and transmediality by examining the adaptation of Charlie Chan’s literary and cinematic portrayal in English and Italian. As a Chinese American fictional detective created by E.D. Biggers in the 1920s (often accused of stereotyping the minority he represents), Charlie Chan navigates various cultural contexts, providing a rich ground for intermedial comparisons. By employing an intercultural and intermedial approach to Translation Studies, this research sets out to understand how linguistic variation is represented across languages and media.
The analysis intertwines multiple levels of translation, as it investigates the passages from English source to Italian target version of both novel and film (interlingual translation), as well as the novel-film adaptation as a form of rewriting (and therefore of medium translation). In particular, the focus will be on how Chan’s language variation, with specific attention to those traits that are supposed to delineate his fictional ‘Chineseness’, may have changed across these multiple translational passages. The findings of this research reveal that the different versions preserve and adapt to various extents Chan’s portrayal, and that both different languages and media contribute to a nuanced understanding of the complexities in the (stereotyped) representation of the image of minority characters.
Los acuerdos offset en la cooperación Colombia-Brasil, 2014-2020
Authors: Carreño-Vargas Melanie Daniela , Morales-Rincón Laura Sofía , Maya Yaqueno Tania Camila , Rincón-Vargas Linda Cristiam
Published: February 2024

Los acuerdos de compensación en el comercio internacional, realizados por países emergentes en proceso de consolida­ción de grandes economías, emplean los offset como instrumento para promover el crecimiento económico e industrial. Estos acuerdos ofrecen una alternativa a la adquisición de bienes de defensa mediante contratos establecidos por com­pañías proveedoras con otros países, con el objetivo de incorporar los productos necesarios. Con los offset, se logran múltiples beneficios económicos, generación de empleo, transferencia de tecnología e, incluso, el fortalecimiento de la competitividad de las exportaciones del país comprador. Para comprender mejor los beneficios y la importancia de estos acuerdos, el presente documento propone un enfoque metodológico cuantitativo y descriptivo que expone los conceptos y los factores que influyeron en Colombia y Brasil al adoptar esta modalidad de cooperación en el mercado.
EVALUASI KEPUASAN PASIEN DI UNIT KEFARMASIAN PUSKESMAS KALASAN
Authors: Karina Putri Astri
Published: February 2024

Latar Belakang: Pelayanan kefarmasian sangat penting dilakukan untuk menciptakan pelayanan kesehatan yang baik dan bermutu di masyarakat. Mengingat pelayanan kefarmasian memengang peranan penting yang tidak dapat dipisahkan dari pelayanan puskesmas. Sehingga Penting untuk melakukan analisis kepuasan pasien di Instansi Puskesmas Kalasan.
Tujuan Penelitian: Untuk mengevaluasi tingkat kepuasan pasien terhadap kualitas pelayanan kefarmasian pada unit pelayanan kefarmasian di Instansi Puskesmas Kalasan.

Metode Penelitian: Jenis penelitian ini adalah kuantitatif. Lokasi penelitian di Puskesmas Kalasan dan waktu penelitian pada bulan Febuari 2023 sampai Maret 2023. Populasi pada penelitian ini adalah seluruh pasien yang melakukan kunjungan/ pemeriksaan dan melakukan pengambilan obat di unit kefarmasian Puskesmas Kalasan. Penarikan sampel penelitian ini menggunakan teknik non probability sampling yaitu purposive sampling. Sampel sebanyak 100 responden. Penilaian kualitas layanan dengan menggunakan analisis GAP.

Hasil: Nilai gap dimensi reliability sebesar 0,60, artinya pasien merasa puas pada kualitas pelayanan Kefarmasian Puskesmas Kalasan dimensi reliability. Dimensi responsiveness memiliki nilai gap sebesar 0,64, artinya artinya pasien merasa puas pada kualitas pelayanan Kefarmasian Puskesmas Kalasan dimensi responsiveness. Dimensi assurance memiliki nilai gap sebesar 0,69, artinya artinya pasien merasa puas pada kualitas pelayanan Kefarmasian Puskesmas Kalasan dimensi assurance. Dimensi empaty memiliki nilai gap sebesar 0,58, artinya pasien merasa puas pada kualitas pelayanan Kefarmasian Puskesmas Kalasan dimensi empaty. Dimensi tangble memiliki nilai gap sebesar 0,57, artinya artinya pasien merasa puas pada kualitas pelayanan Kefarmasian Puskesmas Kalasan dimensi tangble. 

Simpulan: Pasien puas terhadap kualitas pelayanan instansi kefarmasian Puskesmas Kalasan. 

 

Kata Kunci: Kualitas Pelayanan; Kepuasan Pasien