bluuebunny/crossref_metadata_2025 huggingface dataset:
Residues from the Fundão dam accident in Brazil and their effects on photosynthetic efficiency of two restinga plant species
Authors: Lopes Namir Gabriely Matos , Campostrini Eliemar , França Marcel Giovanni Costa , Silva Diolina Moura
Published: November 2023

In 2015, a breach in the Fundão Dam in Mariana (Minas Gerais State, Brazil) resulted in the release of contaminated tailings into the Doce River basin. This accident increased the concentrations of arsenic (As), lead (Pb), cadmium (Cd), vanadium (V), and manganese (Mn) in the soil, posing a potential hazard to the physiology of native species. Therefore, this study aimed to assess whether chlorophyll a fluorescence (ChlF) in Allagoptera arenaria and Guapira pernambucensis changed following this accident when tested under different precipitation regimes in relation to soil properties, and heavy metal absorption. Our research was conducted in the Environmental Protection Area of Conceição da Barra (APA) and the Comboios Biological Reserve (RBC) located in the state of Espírito Santo, Brazil, south-eastern Brazil. Five independent biological replicates of A. arenaria and G. pernambucensis were selected at each site for nutritional and chlorophyll a fluorescence analysis. Soil samples from APA and RBC had similar metal concentrations and physical properties. Five years after the dam rupture, A. arenaria had absorbed As, Pb, and V. The increased amounts of heavy metals absorbed did not significantly impair the OJIP curve configuration in both species during the evaluated periods. However, A. arenaria at RBC during the rainy season showed increases in the values of φR0, φP0, PITOTAL, and φE0. Cluster analysis indicated that ChlF in both species was more sensitive to variations in heavy metals within plant tissues. Then, ChlF variation indicated that A. arenaria and G. pernambucensis exhibited an acclimation strategy in response to increased absorption of heavy metals.
Industrial Product Surface Defect Detection via the Fast Denoising Diffusion Implicit Model
Authors: wang yue , Yang Yong , Liu Mingsheng , Tang Xiangtong , Wang Haibin , Hao Zhifeng , Shi Ze , Wang Gang
Published: November 2023

In the age of intelligent manufacturing, surface defect detection plays a pivotal role in the automated quality control of industrial products, constituting a fundamental aspect of smart factory evolution. Considering the diverse sizes and feature scales of surface defects on industrial products and the difficulty in procuring high-quality training samples, the achievement of real-time and high-quality surface defect detection through artificial intelligence technologies remains a formidable challenge. To address this, we introduce a defect detection approach grounded in the Fast Denoising Probabilistic Implicit Model. Firstly, we propose a noise predictor influenced by the spectral radius feature tensor of image. This enhancement augments the ability of generative model to capture nuanced details in non-defective areas, thus overcoming limitations in model versatility and detail portrayal. Furthermore, we present a loss function constraint based on the Perron root. This is designed to incorporate the constraint within the representational space, ensuring the denoising model consistently produces high-quality samples. Lastly, comprehensive experiments on both the Magnetic Tile and Market-PCB datasets, benchmarked against nine most representative models, underscore the exemplary detection efficacy of our proposed approach.
Efficacy of lysostaphin-coated titanium plates on implant- associated MRSA osteitis in minipigs
Authors: Jaekel Carina , Windolf Ceylan D. , Bieler Dan , Oezel Lisa , Seiler Lars F. , Lakomek Felix N. , Beyersdorf Christoph , Mertens Jann , Steuwe Andrea , Windolf Joachim , Grassmann Jan P.
Published: November 2023

Purpose. The growing incidence of implant-associated infections (IAIs) caused by biofilm-forming Staphylococcus aureus in combination with an increasing resistance to antibiotics requires new therapeutic strategies. Lysostaphin has been shown to eliminate this biofilm. Own studies confirm the effectiveness in a murine model. The current study characterizes the effects of lysostaphin-coated plates in an IAI minipig model.
Methods. The femur of 30 minipigs was stabilized with a 5-hole plate, a bone defect was created, and in 20 cases methicillin-resistantStaphylococcus aureus was applied. 10 animals served as control group. After 14 days, local debridement, lavage, and plate exchange (7-hole plate) were performed. 10 of the infected minipigs received an uncoated plate and 10 a lysostaphin-coated plate. On day 84, the minipigs were again lavaged, followed by euthanasia. Bacterial load was quantified by colony-forming units (CFU). Immunological response was determined by neutrophils, as well as interleukins. Fracture healing was assessed radiologically.
Results. CFU showed significant difference between infected minipigs with uncoated plate and minipigs with lysostaphin-coated plate (p=0.0411). The infection-related, excessive callus formation and calcification was significantly greater in the infected animals with uncoated plate than in animals with lysostaphin-coated plate (p=0.0164 / p=0.0033). The analysis of polymorphonuclear neutrophils and interleukins did not reveal any pioneering findings.
Conclusion. This study confirms the minipig model for examining IAI. Furthermore, coating of plates using lysostaphin could be a promising tool in the therapeutic strategies of IAI. Future studies should focus on coating technology of implants and on translation into a clinical model.
Layer-specific hypoxic responses to spreading depolarizations in gyrencephalic swine cortex unveiled by photoacoustic imaging
Authors: Santos Edgar , Lopez-Navarro Juan M. , Suarez-Gutierrez Marcos A. , Holzwarth Niklas , Albiña-Palmarola Pablo , Kirchner Thomas , Hernandez-Aguilera Adrian , Fernandez-Amador Jose Antonio , Vazifehdan Farzam , Woitzik Johannes , Maier-Hein Lena , Sanchez-Porras Renan
Published: November 2023

Spreading depolarizations (SDs) are a marker of brain injury and have a causative effect on ischemic lesion progression. The hemodynamic responses elicited by SDs are contingent upon the metabolic integrity of the affected tissue, with vasoconstrictive reactions leading to pronounced hypoxia often indicating poor outcomes. The stratification of hemodynamic responses within different cortical layers remains poorly characterized. This study sought to elucidate the layer-specific hemodynamic changes in response to SDs within the gray matter of the gyrencephalic swine brain. To achieve this, we employed multispectral photoacoustic imaging (PAI) to estimate regional cerebral oxygen saturation (rcSO2%) changes consequent to potassium chloride induced SDs. Regions of interest were demarcated at three cortical depths covering up to 4 mm. Electrocorticography (ECoG) strips were placed to validate the presence of SDs. Through PAI, we detected 12 distinct rcSO2% responses, which corresponded with SDs detected in ECoG. Notably, a higher frequency of hypoxic responses was observed in the deeper cortical layers compared to superficial layers, where hyperoxic and mixed responses predominated (p < 0.001). This data provides novel insights into the differential oxygenation patterns across cortical layers in response to SDs, underlining the complexity of cerebral hemodynamics post-injury.
Maternal Serum Concentrations of Vitamin D Early in Pregnancy and Preterm Birth: A Case-Control Study in Southern Sweden
Authors: Olstrup Henrik , Rylander Lars , Lindh 'Christian , Malm Gunilla , Vilhelmsson Andreas
Published: November 2023

Purpose
The purpose of this case-control study was to investigate the associations between maternal serum concentrations of vitamin D early in pregnancy and the occurrence of preterm birth.
Methods
The study included 269 women (cases) whose children were born preterm (< 37 gestational weeks [gw]) and 332 women (controls) whose children were born term (≥ 37 gw). Among the cases, 59 were extreme preterm (< 28 gw), 74 severe preterm (28‒32 gw), and 136 late preterm (33‒36 gw). All women gave birth in Scania, the most Southern County of Sweden. Concentrations of 25-hydroxyvitamin D3 (vitamin D) in maternal serum collected early in pregnancy were analyzed using liquid chromatography-tandem-mass-spectrometry (LC/MS/MS). The serum concentrations of vitamin D were trichotomized based on the distributions among the controls (≤ 44.9; 45.0‒68.8; and ≥ 68.9 nmol/L) as well as dichotomized at a predefined cut-off (< 50 and ≥ 50 nmol/L). Logistic regression was used to estimate the associations between vitamin D and preterm births, partly when all cases were included in the analyses, and partly when the three different case groups were included separately. The category with the highest vitamin D concentration was used as a reference in the regression analyzes. The analyses were performed without as well as with adjustments for potential confounders.
Results
When the category with the lowest vitamin D concentrations were compared with the reference category in the analyses where the vitamin D concentrations were trichotomized, no statistically significant associations were observed. However, among the extreme preterm an adjusted odds ratio of 1.93 (95% confidence interval 0.83‒4.48) was observed. The patterns were similar when 50 nmol/L was used as the cut-off.
Conclusion
Although all comparisons gave adjusted odds ratios in the direction that low maternal vitamin D concentrations early in pregnancy increase the risk of preterm birth, none of these were statistically significant. Accordingly, the present study gives no to very weak support for an association.
The rise of multi-stakeholderism, the power of ultra-processed food corporations, and the implications for global food governance: a network analysis
Authors: Slater Scott , Lawrence Mark , Wood Benjamin , Serodio Paulo , Akker Amber Van Den , Baker Phillip
Published: November 2023

In recent decades, multi-stakeholder institutions (MIs) involving the ultra-processed food (UPF) industry have presented themselves as "part of the solution" to addressing malnutrition and other food systems sustainability challenges. This has raised concerns for many health and global food governance (GFG) scholars; however, few studies have investigated the governance composition and characteristics of these MIs, nor considered the implications for responses to UPFs and other major food systems challenges. We aimed to address this gap by conducting a network analysis, drawing quantitative and qualitative data from web sources, company reports, business and market research databases, and relevant academic and grey literature. In total, 45 global food systems MIs were identified. When combined, UPF industry executives and their business associates held almost half (n=263, or 43.8%) of the total 601 MI leadership positions, with Unilever (n=20), Nestlé (n=17), PepsiCo Inc (n=14), and The Coca-Cola Company (n=13) the most central to the network. Categorisation by various characteristics showed that corporations (n=431, or 71.7%), high-income countries (n=495, or 82.4%), and four countries (United States, Switzerland, United Kingdom, and the Netherlands) (n=350, or 58.2%) in particular, are dominant amongst the leadership of the MIs analysed. This study provides empirical evidence that many MIs, both hide the UPF industry’s harmful effects, and continue the perpetuation of long-standing food system inequalities and injustices. MIs involving the UPF industry are now a major structural feature of the GFG system, and regulatory changes are needed, to ensure a public health and sustainability first approach in GFG is prioritized.
Wissenschaft im digitalen Raum: Exemplarische Entwicklungen in Österreich und Deutschland
Authors: Wannemacher Klaus , Kaemena Alena
Published: November 2023

Der Kommentar versucht eine Betrachtung und Einordnung der Beiträge der vorliegenden Sonderausgabe zur Digitalisierung in der Forschung an österreichischen Hochschulen aus der Perspektive des deutschen Hochschul- und Wissenschaftssystems. Dabei wird versucht, aktuelle Entwicklungslinien in Deutschland aufzugreifen und auf vergleichbare Forschungsprojekte, Infrastrukturentwicklungen und Fördermaßnahmen hinzuweisen. Diese stehen idealiter paradigmatisch für allgemeine Entwicklungstendenzen in der deutschen Forschungslandschaft, ohne dass angesichts der großen disziplinären Breite der Beiträge dieser Sonderausgabe eine erschöpfende Betrachtung möglich war. Die vergleichende Auswertung deutet darauf hin, dass Gemeinsamkeiten in vielen Bereichen bestehen, dass jedoch ausgewählte Aspekte vorbildhaften Charakter für die Hochschullehre in Deutschland haben könnten.
INTERNALISASI PERAN PEMUDA DALAM MENGAKSELERASI LITERASI DAN PENGEMBANGAN PARIWISATA HALAL DENGAN KONSEP FIREFLIES ARISING SCENARIO (FAS)
Authors: Hariadi Muh Ikhsan
Published: November 2023

Abstrak: Tulisan ini mengkaji bagaimana perananan pemuda sebagai aset bangsa dalam mengakselerasi proses literasi dan pengembangan pariwisata halal di Indonesia. Outlook pengembangan pariwisata halal di Indonesia yang dirilis oleh GMTI 2023 cukup menjanjikan di masa depan serta mampu meningkatkan perekonomian secara keseluruhan. Oleh karena itu diperlukan langkah-langkah strategis dari semua pihak untuk mengawal potensi tersebut supaya bisa tercapai dengan maksimal. Dalam kesempatan ini penulis menawarkan konsep Fireflies Arising Scenario (FAS). FAS menceritakan bagaimana mentransformasikan bangsa dengan gerakan-gerakan kecil, tak perlu slogan bombastis disana-sini. Konsep FAS akan terinternalisasi dengan peran pemuda serta terkoneksi dengan seluruh pemangku peran yang ada yaitu pemerintah, stakeholder, masyarakat dan lembaga keuangan. Masing-masing menjalankan fungsinya dan saling bersinergi melalui gerakan kecil secara massif dan konsisten. Konsep yang ditawarkan ini harapanya akan mampu membawa percepatan dalam pengembangan pariwisata halal di Indonesia. Sehingga geliat perkomonian melalui sektor pariwisata akan semakin kuat dan sektor pariwisata halal di Indonesia akan semakin dikenal dan membudaya oleh masyarakat dan seluruh dunia

Kata Kunci : Peran Pemuda; Pariwisata Halal; Fireflies Arising Scenario (FAS)

 

Abstract: This paper examines the role of youth as a national asset in accelerating the process of literacy and development of halal tourism in Indonesia. The outlook for the development of halal tourism in Indonesia released by GMTI 2023 is quite promising in the future and is able to improve the economy as a whole. Therefore, strategic steps are needed from all parties to guard this potential so that it can be optimally achieved. On this occasion the author offers the concept of Fireflies Arising Scenario (FAS). FAS tells how to transform a nation with small movements, no need for bombastic slogans here and there. The FAS concept will be internalized with the role of youth and connected with all existing stakeholders, namely government, stakeholders, communities and financial institutions. Each of them carries out its function and synergizes with each other through massive and consistent small movements. The concept offered is hoped to be able to bring acceleration in the development of halal tourism in Indonesia. So that the stretching of the communion through the tourism sector will get stronger and the halal tourism sector in Indonesia will become increasingly recognized and entrenched by the public and throughout the world.

Keywords : The Role of Youth; Halal Tourism; Fireflies Arising Scenario (FAS)
AVALIAÇÃO DOS NÍVEIS DE NÍQUEL NO AR E NA URINA DE MORADORES PRÓXIMOS A UMA INDÚSTRIA E DEPÓSITO DE REJEITOS SIDERÚRGICOS NO MUNICÍPIO DE VOLTA REDONDA, RJ
Authors: Borges Renato , Soares Ruan Victor , Gomes Regina , Moreira Maria , Cassella Ricardo
Published: November 2023

NICKEL EVALUATION IN THE AIR AND IN THE URINE OF PEOPLE WHO LIVE NEAR TO AN INDUSTRY AND A STEEL TAILING DEPOSIT IN THE CITY OF VOLTA REDONDA, RJ, BRAZIL. Steelmaking is an important industrial branch, but it is also associated with large emissions of pollutants into the environment, especially nickel, which is used in the manufacturing process of metallic alloys and steel. Nickel is generally associated with particulate matter and, in industrial regions, its concentration can be 14 times higher than those observed in non-industrialized regions. This study was carried out in a residential area located in the city of Volta Redonda, in the state of Rio de Janeiro, which is impacted by industrial steel activity and by a deposit of steel slag tailings. The goal of this study was to measure air contamination and its impact on the health of the population by determining Ni in the total particulate matter and in the urine of 211 residents. The results obtained showed that the average values of Ni in the atmospheric air varied in the range of 1.3-13.2 ng m-3, with a maximum value of 20 ng m-3, which is comparable to other industrialized regions. In turn, Ni concentration in the urine of the residents presented an average concentration of 3.61 µg L-1, which is higher than the values normally found in the urine of occupationally exposed persons.
Preservation of Community Values: Study of the Samin Bojonegoro Teaching Transformation Model Through the Education Unit Curriculum
Authors: Sulanam Sulanam , Huda Muhammad Nuril
Published: November 2023

This article explains the process of instilling values, which is carried out by internalizing community teachings through educational units. The internalization of values is achieved by inserting Samin's noble pitutur in PAI and PPKn subjects at elementary, middle and high school levels. The choice of this educational institution indicates that schools have a strategic role in preserving values. This participatory action research was conducted in Dusun, Japan, a hamlet inhabited by the Samin Bojonegoro community. This community adheres to the teachings of its ancestors. However, on the other hand, the openness in this community also allows for a permissive attitude, which has the potential to erode the strength of their traditions. The research was carried out for four months, starting with problem mapping, problem analysis and action involving traditional stakeholders, policy stakeholders and education stakeholders. The choice of action taken is to insert community values through Islamic Religious Education and Character subjects and Pancasila and Citizenship Education subjects. This insertion is a cultural preservation strategy that stakeholders consider to be the right step because, through this institution, children can internalize the noble values that exist around them.
The Quality Improvement Assistantship Program for Madrasa Education in Mindanao, the Philippines
Authors: Muhlisin Muhlisin , Sofi Muhammad Jauhari , Shobirin Ma’as , Deporos Saprolla Rollie C.
Published: November 2023

Madrasa education is a compelling issue in a Muslim minority country like the Philippines. Amidst the rapid pace of modernization, secular education enjoys strong government support, while Islamic teaching often remains underemphasized. However, the madrasa education system in the Philippines has begun to make positive strides through mutual learning and exchanging experiences with neighboring countries, such as Indonesia. Likewise, the present intensive and participatory assistantship program aimed to elucidate the efforts to promote religious moderation and enhance the educational quality within selected madrasas in Mindanao, the Philippines. The Participatory Action Research (PAR) method, combined with direct mentoring, was employed in this endeavor. Furthermore, the program was designed to address three key objectives: (1) strengthening religious moderation within madrasa education, (2) preparing professional teachers for madrasa education, and (3) enhancing the management of madrasa education. In summary, the outcomes of this program have the potential to contribute to the adoption of the Indonesian Islamic education model within the Muslim community in the Philippines.
Increasing Student’s Understanding on Adolescent Reproductive Health Trough the Crossword Puzzle Media and Learning Videos Aided Counseling
Authors: Wijayanti Erna , Rahmawati Titik , Syaroni Mokh , Arafat Ahmad Tajuddin , Saadah Ira Naila , Purnamaningrum Arifah , Rasyida Nisa
Published: November 2023

Adolescence is important for students because it transitions from childhood to adulthood. Knowledge about changes in adolescence, especially adolescents in Islamic boarding schools regarding adolescent reproductive health, is still low, so it needs to be improved. This service aims to increase the knowledge of service partners, especially students in Islamic boarding schools, regarding adolescent reproductive health. This devotion used the ABCD method, which consists of five stages: inculturation, discovery, design, definition, and reflection. This service program is carried out in July–August 2022. Service partners are students from classes X, XI, and XII. The service program is carried out with a learning model of team games tournaments (TGT) assisted by crossword puzzles and learning videos. Service data were obtained using pre- and post-tests regarding adolescent reproductive health. The data obtained are analyzed qualitatively and descriptively. The service results showed that counselling activities using crossword puzzle media and learning videos increased the knowledge of service partners by an average of 8.41.
Analysis of Reports on the Occupational Health and Safety in The Agricultural Industry: A bibliometrix-Aided Approach
Authors: ÖZBAKIR Okan
Published: November 2023

Agricultural activities are fundamental to societies, including the planting, growing, harvesting and processing of agricultural crops. However, there are a large number of occupational risks that can arise during the course of agricultural activities. These risks could result in serious injury or even death. This requires introducing and providing the relevant bodies and workers with knowledge, perception and awareness of the risk. The present study assessed the available reports on occupational health and safety using a bibliometric analysis and dimension reduction approach. Briefly, the reports were extracted from SCOPUS database. We identified 943 relevant and available peer-reviewed publications from the Scopus database. These were published between 1956 and 2022. The retrieved documents were analysed with the R-studio based software Bibliometrix. For the analysis, co-occurrences of networks, thematic maps and trending topics were analyzed. The results of the present study show that the time span of the documents ranges from 1956 to 2022 and these documents, including journals, books, book chapters and conference papers, were disseminated in 313 different sources. The estimated annual growth rate of these documents is 6.35%. Even the first paper dates back to the 1950s, the average age of the documents are 10.7. Considering the spatial distribution of the documents, USA topped at the list and was followed by Australia, Brazil, Italy, Canada, UK, and China. It is interesting to note that 'confined spaces' were found to be the trending topic according to the trend topic analysis of the keywords. Also, after the basic keywords (occupational health and safety and agriculture) of the study, ergonomics was the core keyword of the relevant analysis. Critically, the level of co-operation between countries was very low, with a rate of 0.025-0.207 for co-operation between countries (MCPs). For Turkey, the MCP was found to be 0.000. According to the thematic map, the motor theme is composed of two major clusters. One relates to food safety, risk analysis, knowledge and awareness and hygiene. To the best of our knowledge, this is the first study of its kind to identify the key issues in occupational health and safety in the agricultural industry. Therefore, the study has potential to contribute to the field.
Cephalaria tchihatchewii Boiss. Ekstrelerinin Antioksidan Aktivitesi, Metabolik Enzimler Üzerine Etkisi ve UPLC-MS/MS Analizi ile Kimyasal Karakterizasyonun Belirlenmesi
Authors: GÜVEN Leyla
Published: November 2023

Bu çalışma, Cephalaria tchihatchewii Boiss'in metanol ve su ekstrelerinin (MECT, WECT) UPLC-MS/MS kullanarak kapsamlı bir kimyasal karakterizasyonunu gerçekleştirmeyi ve bu ekstrelerin potansiyel antioksidan aktivitesinin ve bazı metabolik enzimler üzerindeki etkisini değerlendirmeyi amaçlamaktadır. Antioksidan aktivite, DPPH, ABTS, DMPD, FRAP, KUPRAK ve Fe3+ indirgeme testleri dahil olmak üzere çeşitli testler kullanılarak değerlendirilmiştir. MECT ve WECT'in enzim inhibisyon IC50 değerleri, sırasıyla α-glikozidaz için 28.98 ve 34.19 μg/mL, asetilkolinesteraz için 21.82 ve 26.52 μg/mL ve karbonik anhidraz II için 27.75 ve 13.72 μg/mL’dir. MECT ve WECT'de bulunan fenolik bileşik miktarları sırasıyla 47.00 ve 46.00 μg GAE /mg ekstre, flavonoit miktarları 60.98 ve 49.34 μg KE/mg ekstre olarak belirlenmiştir. MECT ve WECT’in IC50 değerleri sırasıyla DPPH için 34.66 ve 57.76 μg/mL, ABTS için 20.39 ve 17.33 μg/mL ve DMPD için 53.32 ve 57.76 g/mL’dir. Ekstrelerin indirgeme yetenekleri ise sırasıyla Fe+3 indirgeme (λ700:0.377 ve 0.680), FRAP (λ593:0.690 ve 0.369) ve KUPRAK (λ450:0.458 ve 0.333)’dür. UPLC-MS/MS analiziyle elde edilen sonuçlara göre ana bileşenler MECT’in kinik asit 0.39844 µg/mL, klorojenik asit 38.412 µg/mL, fumarik asit 0.301 µg/mL ve WECT’in klorojenik asit 13.639 µg/mL, kinik asit 11.004 µg/mL, siyanidin-3-O-glukozit 0.778 µg/mL olduğu belirlenmiştir. Ekstrelerin, antioksidan aktivite ve α-glikosidaz, asetilkolinesteraz, karbonik anhidraz II enzim ihbisyon etkisi dahil olmak üzere çeşitli biyolojik aktivitelere sahip olduğu belirlenmiştir.
Effect of field of view of canopy temperature observations on crop water stress index for irrigation scheduling
Authors: Yadav Aditi , Upreti Hitesh , Singhal Gopal Das
Published: November 2023

The monitoring of canopy temperature (Tc) helps to establish appropriate watering methods. This study calculates the crop water stress index (CWSI) for four irrigation regimes in semi-arid region, India. Plots 1, 2, 3, and 4 had soil moisture depletion of 50% (drip system), 25% (drip system), unregulated (farmer replicated flood system), and 50% (flood system) with irrigation. In this work, we examined the value of employing a portable infrared thermometer (IRT) to measure wheat canopy temperature (Tc) at two geographical locations. The IRT field of view is 51.28–5,128 cm2, or 10–100 cm from the canopy crown. The field of view change from 10 to 100 cm affects Tc and CWSI in the four irrigation treatments, ranging from 0.65 to 2.71% and 9.2 to 36.4%, respectively. The research found that increasing the IRT from 10 to 100 cm reduced slope by 5.7% and intercept by 20.6% in lower baselines. The R2 for CWSI and soil moisture was 0.78 (10 cm) and 0.77 (100 cm). Drip-irrigated plots are more sensitive to IRT spatial resolution than flood-irrigated plots. The findings suggest that CWSI studies may benefit from specific sample methods for Tc evaluation.
Celia se pudre
Authors: Rojas Herazo Héctor
Published: November 2023

“Celia se pudre” es la continuación de una saga iniciada en la década de los sesenta con "Respirando el verano" y "En noviembre llega el arzobispo", este es un libro clave por la belleza del personaje de Celia, por la narración de la vida cotidiana de un lugar llamado Cedrón y por la evocación que de aquel poblado hacen desde la ciudad diversas voces lejanas. Una larga novela sobre la melancolía reeditada en cuatro tomos que abarcan más de ochocientas páginas, acompañadas de notas críticas. “Celia se pudre” es una prosa caudalosa, material, fragmentada, ajena a la utilidad de la trama. El libro es un llamado a explorar la multiplicidad colombiana desde el pensamiento material, corpóreo del Caribe. En esta colosal imagen -pensamiento, Rojas Herazo diluye el tiempo como línea estructural de la narración. En contraposición, bien puede percibirse como un tapiz de hilos existenciales, con tramas del Caribe y Bogotá, sobre experiencias que huyen a la filosofía como una actividad frígida de una mente atrapada en un sujeto. Es la consolidación de un proceso artístico e intelectual en el que la alteridad del autor como caribeño frente al proyecto nacional ha sido refinada al máximo, así como su contribución al pensamiento y a la historia intelectual.
EMANCIPAÇÃO
Authors: Mora Casasola Maria Fernanda
Published: November 2023

A pesquisa objetivou problematizar o percurso histórico-filosófico do conceito emancipação desde o século XVII até o século XX, a partir dos seguintes autores selecionados: Immanuel Kant, Theodor Adorno, Max Horkheimer e alguns representantes dos movimentos de emergência e inmersão  de projetos educativos e pedagógicos de Latinoamerica: Paulo Freire, Dermeval Saviani, Enrique Dussel e Marco Raúl Jiménez. Destacam-se algumas implicações desse conceito nas diferentes mudanças dos modelos sociais presentes nestas épocas. Trata-se de uma pesquisa bibliográfica, de natureza qualitativa. Ao abordar o conceito de emancipação, com ideias tais como: a emergência da consciência e a autonomia, surge o princípio de que a educação pode ser um meio para que o homem se torne homem. Portanto esse estudo indica a importância da consolidação de um projeto de educação democrática e inclusiva, que faça rupturas com paradigmas conservadores ancorados no ideário neoliberal que, na última década, tem se espraiado, especialmente no campo das políticas educacionais.
Unlocking the Benefits of Fasting: A Review of its Impact on Various Biological Systems and Human Health
Authors: Mackieh Rawan , Al-Bakkar Nadia , Kfoury Milena , Okdeh Nathalie , Pietra Hervé , Roufayel Rabih , Legros Christian , Fajloun Ziad , Sabatier Jean-Marc
Published: November 2023

Fasting has gained significant attention in recent years for its potential health benefits in various body systems. This review aims to comprehensively examine the effects of fasting on human health, specifically focusing on its impact on different body’s physiological systems. The cardiovascular system plays a vital role in maintaining overall health, and fasting has shown promising effects in improving cardiovascular health markers such as blood pressure, cholesterol levels, and triglyceride levels. Additionally, fasting has been suggested to enhance insulin sensitivity, promote weight loss, and improve metabolic health, thus offering potential benefits to individuals with diabetes and metabolic disorders. Furthermore, fasting can boost immune function, reduce inflammation, enhance autophagy, and support the body's defense against infections, cancer, and autoimmune diseases. Fasting has also demonstrated a positive effect on the brain and nervous system. It has been associated with neuroprotective properties, improving cognitive function, and reducing the risk of neurodegenerative diseases, besides the ability of increasing the lifespan. Hence, understanding the potential advantages of fasting can provide valuable insights for individuals and healthcare professionals alike in promoting health and wellbeing. The data presented here may have significant implications for the development of therapeutic approaches and interventions using fasting as a potential preventive and therapeutic strategy.
Synthetic and Biological Studies of Some Pyrrolidine-Tethered Novel Aurones against
Digestive Enzymes
Authors: Kumar Sanjeev , Saroha Bhavna , Lathwal Ekta , Kumar Gourav , Arya Priyanka , Raghav Neera , Kumar Ramesh , Kumar Suresh
Published: November 2023

Amylase, lipase, and trypsin are crucial digestive enzymes, whose activation or
inhibition is of potent therapeutic approach for treating various body disorders. In this
work, we have synthesized a small library of pyrrolidine-tethered novel aurones 4(a-k) and
structures validated by analyzing their IR, NMR (1H and 13C), and mass spectrometry data.
The biological activities of the synthesized aurones were evaluated through in vitro and in
silico experiments against digestive enzymes. A distinct pattern emerged, with significant
activation observed for trypsin and amylase, while lipase was notably inhibited. Among the
synthesized compounds, 4f produced the highest lipase inhibition (72.3%), whereas 4k
showed maximum activation for trypsin (EC50 = 0.94×10-6 M) and 4f activated amylase
(EC50 = 8.76×10-4 M) to the maximum extent, thus confirming their possible use as agents
for combating inflammation and obesity.
Hsa_circ_0001278 Facilitates Colorectal Cancer Progression via Sponging miR-338-5p and Regulating AMOTL1 Expression
Authors: Ge Hua , Yan Yan , Wang Haomin , Bian Jun , Deng Zhilong , Su Xian , Yang Zaicai , Song Jiacheng
Published: November 2023

Background:

Colorectal cancer (CRC) ranks as the third most common cancer and is
second in terms of mortality worldwide. Circular RNAs are involved in the occurrence and development
of malignant tumors by functioning either as oncogenes or tumor suppressors.

Method:

This study investigated the functions of hsa_circ_0001278 in CRC. We analyzed the
expression of hsa_circ_0001278 in CRC tissues and adjacent normal tissues. In order to understand
the roles of hsa_circ_0001278 in CRC in terms of cellular biological behavior, in vitro experiments
were conducted. A mechanistic study was designed to investigate the regulatory effect
of hsa_circ_0001278 on CRC.

Results:

Hsa_circ_0001278 was found to be significantly upregulated in CRC specimens. The
functional analysis indicated that hsa_circ_0001278 promotes aggressive phenotypes of CRC
cells. Further mechanistic studies revealed that hsa_circ_0001278 sponges miR-338-5p to regulate
angiomotin-like 1 (AMOTL1), thereby facilitating CRC progression.

Conclusion:

Our results demonstrate that hsa_circ_0001278 promotes malignant behaviors in
CRC cells by sponging miR-338-5p to regulate AMOTL1 expression. This suggests that
hsa_circ_0001278 may serve as a novel target for CRC treatment.
Splicing DNA Damage Adaptations for the Management of Cancer Cells
Authors: Singh Arun Kumar , Yadav Deepika , Malviya Rishabha
Published: November 2023

Maintaining a tumour cell's resistance to apoptosis (organized cell death) is essential
for cancer to metastasize. Signal molecules play a critical function in the tightly regulated apoptotic
process. Apoptosis may be triggered by a wide variety of cellular stresses, including DNA damage,
but its ultimate goal is always the same: the removal of damaged cells that might otherwise
develop into tumours. Many chemotherapy drugs rely on cancer cells being able to undergo apoptosis
as a means of killing them. The mechanisms by which DNA-damaging agents trigger apoptosis,
the interplay between pro- and apoptosis-inducing signals, and the potential for alteration of these
pathways in cancer are the primary topics of this review.
The Re-emergence of Diphtheria Amidst Multiple Outbreaks in Nigeria
Authors: Omosigho Pius Omoruyi , John Okesanya Olalekan , Adigun Olaniyi Abideen , Hassan Hakeem Kayode , Olabode Olaleke Noah , Micheal Abioye Sunday , Haruna Usman Abubakar , Singh Amandeep , Manirambona Emery
Published: November 2023

Diphtheria, a vaccine-preventable disease, has resurfaced in Nigeria, where many outbreaks have been reported in recent years. The outbreaks have occurred across the country, including
in areas with high vaccination coverage. Corynebacterium diphtheriae, the causal agent, is a highly
contagious bacteria that can cause severe respiratory and systemic symptoms and can be fatal if not
treated. The reemergence of diphtheria in Nigeria is most likely due to a combination of factors, including gaps in routine immunization regimens. The outbreak is further aggravated by multiple epidemics, which have diverted resources and attention away from the emergency of other infectious
diseases. Furthermore, there is a lack of awareness of diphtheria in Nigeria. With a focus on the difficulties in controlling the disease, methods of diagnosis, available treatments, and preventive
measures, this study provides a thorough analysis of diphtheria, covering its historical context, clinical presentation, associated complications, and current outbreaks. It emphasizes how important vaccination, early detection, and better access to healthcare are in reducing diphtheria outbreaks. The
study highlights the serious effects of diphtheria on public health, particularly in regions with scarce
resources and vaccine resistance, and offers a number of suggestions to overcome these challenges
and prevent further outbreaks.
Unlocking the Potential: A Comprehensive Review for the Synthesis of Benzofuran Derivatives
Authors: Patel Krina , Patel Heli , Shah Drashti , Patel Dharti , Savaliya Neel , Bambharoliya Tushar , Shah Ashish , Mahavar Anjali , Patel Ashish
Published: November 2023

Benzofuran, a versatile heterocyclic compound, has gained considerable attention in recent years due to its diverse biological activities, distinctive structural characteristics, broad synthetic approaches, and extensive applications. The growing potential inherent in benzofuran encourages many researchers to address the challenges of the synthesis of its framework. This comprehensive review aims to provide a detailed overview of the recent advancements in the synthesis of diverse benzofuran derivatives, highlighting innovative strategies, synthetic methodologies, and significant breakthroughs in the field. The synthetic methodologies are classified as metalcatalyzed routes, green-solvent-based routes, microwave-assisted methods, catalyst-free and solvent- free methods, and a miscellaneous group of routes. This categorization in review provides an easy means for the reader to rationally select the best possible synthetic method for benzofuran derivatives. In addition, it explores the use of different solvents and catalysts in benzofuran synthesis, which serves as a valuable resource for chemists, researchers, and scientists involved in pharmaceutical and allied sciences. Overall, this review provides a comprehensive overview of the synthesis of benzofuran scaffolds and complies with all the significant developments in the synthetic routes of benzofuran, which will be useful for researchers interested in the development of new benzofuran-based molecules.
A Case Report of Different Management Protocols for Uncomplicated Crown Fracture in Young Permanent Teeth; Fragment Reattachment vs. Resin Restoration
Authors: Alkhuwaiter Shahad S. , Alssafi Fatimah
Published: November 2023

Introduction:

An uncomplicated crown fracture (enamel-dentin fracture) is the most clinically reported traumatic injury. Many techniques have been reviewed to manage this traumatic injury. The literature has no consensus on the best strategy to establish optimal biological, functional, and esthetical success.

Objective:

This clinical case reports different management of uncomplicated crown fractures in young permanent teeth that were successfully treated using both tooth fragment reattachment and composite build-up.

Case Report:

A 9-year-old female presented as an emergency patient with immature fractured upper central incisors. She hit her mouth into a solid wall and broke her front teeth during playing. Upon parental advice, the fragments were stored in a container of milk since the incident. For dental management, two treatment approaches were used.

Conclusion:

After a two-year follow-up, the treatment is considered successful and the traumatized teeth are vital, functional and presented with a complete root development.
Salivary Biomarkers and their Relationship with Periodontal Clinical Parameters: A Cross-Sectional Study
Authors: Marin Rubiel , Duque Andres , Cardona Doris , Giraldo Erika , Salazar Lina
Published: November 2023

Background:

Traditionally, periodontal clinical parameters are used to diagnose and design standardized treatment plans. The scientific literature has not widely reported the inclusion of salivary biomarkers in this diagnostic and therapeutic process.

Objectives:

To analyze the correlation between salivary biomarkers and periodontal clinical parameters of a group of patients undergoing the periodontal maintenance phase in a private dental office located in the southwest of Colombia.

Material and Methods:

A cross-sectional study was carried out. A sample of 92 patients undergoing the periodontal maintenance phase was analyzed. Conventional periodontal parameters were determined, and salivary biomarkers were measured by chromatography (cariogenic bacteria, acidity, buffering capacity, blood, and erythrocytes). To determine its correlation, a bivariate statistical analysis was developed.

Results:

According to Spearman's correlation matrix, among the periodontal clinical parameters, there were statistically significant correlations between the extension and severity of the complete and proximal attachment loss (r=0.93) and between the bleeding on probing (BOP) and the plaque index (PI) (r= 0.37). Within the salivary biomarkers, a statistically significant correlation was found between acidity and the buffering capacity of saliva (r= -0.54); between buffering capacity and proteins (r=0.36); between blood and erythrocytes (r=0.42); between blood and proteins (r=0.58), and between erythrocytes and proteins (r=0.48). Finally, a statistically significant correlation between periodontal parameters and salivary biomarkers was observed between teeth lost due to periodontal disease and acidity (r=0.26) and between teeth lost and buffer capacity (r=0.30).

Conclusion:

Periodontal parameters and salivary biomarkers correlate with variables of the same group to which they belong. Still, only the variable teeth lost due to periodontal disease correlates with acidity and buffer capacity. The findings suggest that both periodontal parameters and salivary biomarkers should be evaluated throughout the periodontal process. It is possible that both parameters could express different moments of the pathophysiology of the disease.
Continuum Space Model for Folding of the Protein Crambin
Authors: Taneri Sencer
Published: November 2023

In Chapter 4, we have studied the chain length dependence of folding time for
proteins by implementing a novel Monte Carlo (MC) method. The physical parameters in our
model are derived from the statistics for bending and torsion angles and distances between the
centers of the monomers up to the fourth neighborhood. By assigning potential wells to each
of the physical parameters, we are able to use a modified Metropolis algorithm to efficiently
trace the later conformations of the proteins as time evolves. Our prescription for microscopic
dynamics for the protein "Crambin" results in an increase in folding times with increasing chain
length. The folding times are determined via Debye relaxation process.
Una especie nueva, Castela juyyaania (Simaroubaceae), y tres registros nuevos para la flora semiárida de Sinaloa, México
Authors: Pío-León Juan F. , Carrillo-García Jesús A. , Salomón-Montijo Bladimir , Márquez-Salazar Gilberto
Published: November 2023

Resumen
Antecedentes y Objetivos: Durante exploraciones biológicas en el bosque espinoso cercano a las costas de Sinaloa, se colectaron especímenes de cuatro taxones no reportadas previamente para este estado, incluyendo el primer registro del género Castela, el cual se trató de una especie nueva para la ciencia. El objetivo de este trabajo fue describir e ilustrar a Castela juyyaania, así como reportar los tres nuevos registros adicionales para la flora de Sinaloa que comparten hábitat con la especie nueva.
Métodos: Se realizaron colectas botánicas en el norte de Sinaloa durante 2022 y 2023. Para la descripción de la especie nueva se consultó la literatura disponible del género, ejemplares de herbarios y bases de datos electrónicas. Se elaboró una clave de identificación para la sección Castela en México, mapa de distribución, lámina comparativa con las especies más relacionadas y evaluación de vulnerabilidad de acuerdo con la Unión Internacional para la Conservación de la Naturaleza (UICN). Para los nuevos registros se presentan fotos y mapas de distribución actualizada.
Resultados clave: Castela juyyaania es microendémica de la Península El Guachapori, en el norte de Sinaloa. Crece en bosque espinoso cercano a la costa, en un área de aproximadamente 25 km2, altamente amenazada por la expansión agropecuaria. De acuerdo con los criterios de la UICN, se propone en la categoría de Peligro Crítico. Se relaciona morfológicamente con el complejo C. erecta, de las que se diferencia por presentar hojas pecioladas, margen no conspicuamente revoluto, estilos presentes y semillas no reticuladas. El área de distribución presenta algunos elementos del desierto sonorense, incluyendo los nuevos registros Ebenopsis confinis, Gossypium davidsonii y Malpighia diversifolia.
Conclusiones: Con la nueva adición, el género Castela llega a siete especies en México con cuatro endémicas, consolidándolo como su principal centro de diversidad. Los nuevos registros y la especie nueva aportan elementos valiosos para la conservación de los bosques secos altamente amenazados en México y Sinaloa.
Ten Years of Experience With a Telemedicine Platform Dedicated to Health Care Personnel: Implementation Report
Authors: Azzolini Claudio , Premi Elias , Donati Simone , Falco Andrea , Torreggiani Aldo , Sicurello Francesco , Baj Andreina , Azzi Lorenzo , Orro Alessandro , Porta Giovanni , Azzolini Giovanna , Sorrentino Marco , Melillo Paolo , Testa Francesco , Simonelli Francesca , Giardina Gianfranco , Paolucci Umberto
Published: November 2023

Background

Telemedicine, a term that encompasses several applications and tasks, generally involves the remote management and treatment of patients by physicians. It is known as transversal telemedicine when practiced among health care professionals (HCPs).

Objective

We describe the experience of implementing our telemedicine Eumeda platform for HCPs over the last 10 years.

Methods

A web-based informatics platform was developed that had continuously updated hypertext created using advanced technology and the following features: security, data insertion, dedicated software for image analysis, and the ability to export data for statistical surveys. Customizable files called “modules” were designed and built for different fields of medicine, mainly in the ophthalmology subspecialty. Each module was used by HCPs with different authorization profiles.

Implementation (Results)

Twelve representative modules for different projects are presented in this manuscript. These modules evolved over time, with varying degrees of interconnectivity, including the participation of a number of centers in 19 cities across Italy. The number of HCP operators involved in each single module ranged from 6 to 114 (average 21.8, SD 28.5). Data related to 2574 participants were inserted across all the modules. The average percentage of completed text/image fields in the 12 modules was 65.7%. All modules were evaluated in terms of access, acceptability, and medical efficacy. In their final evaluation, the participants judged the modules to be useful and efficient for clinical use.

Conclusions

Our results demonstrate the usefulness of the telemedicine platform for HCPs in terms of improved knowledge in medicine, patient care, scientific research, teaching, and the choice of therapies. It would be useful to start similar projects across various health care fields, considering that in the near future medicine as we know it will completely change.