bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuroimaging features in inflammatory myelopathies: A review
Authors: Cacciaguerra Laura , Sechi Elia , Rocca Maria A. , Filippi Massimo , Pittock Sean J. , Flanagan Eoin P.
Published: October 2022

Spinal cord involvement can be observed in the course of immune-mediated disorders. Although multiple sclerosis (MS) represents the leading cause of inflammatory myelopathy, an increasing number of alternative etiologies must be now considered in the diagnostic work-up of patients presenting with myelitis. These include antibody-mediated disorders and cytotoxic T cell-mediated diseases targeting central nervous system (CNS) antigens, and systemic autoimmune conditions with secondary CNS involvement. Even though clinical features are helpful to orient the diagnostic suspicion (e.g., timing and severity of myelopathy symptoms), the differential diagnosis of inflammatory myelopathies is often challenging due to overlapping features. Moreover, noninflammatory etiologies can sometimes mimic an inflammatory process. In this setting, magnetic resonance imaging (MRI) is becoming a fundamental tool for the characterization of spinal cord damage, revealing a pictorial scenario which is wider than the clinical manifestations. The characterization of spinal cord lesions in terms of longitudinal extension, location on axial plane, involvement of the white matter and/or gray matter, and specific patterns of contrast enhancement, often allows a proper differentiation of these diseases. For instance, besides classical features, such as the presence of longitudinally extensive spinal cord lesions in patients with aquaporin-4-IgG positive neuromyelitis optica spectrum disorder (AQP4+NMOSD), novel radiological signs (e.g., H sign, trident sign) have been recently proposed and successfully applied for the differential diagnosis of inflammatory myelopathies. In this review article, we will discuss the radiological features of spinal cord involvement in autoimmune disorders such as MS, AQP4+NMOSD, myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), and other recently characterized immune-mediated diseases. The identification of imaging pitfalls and mimics that can lead to misdiagnosis will also be examined. Since spinal cord damage is a major cause of irreversible clinical disability, the recognition of these radiological aspects will help clinicians achieve a correct and prompt diagnosis, treat early with disease-specific treatment and improve patient outcomes.
Perivascular spaces as a potential biomarker of Alzheimer’s disease
Authors: Lynch Miranda , Pham William , Sinclair Benjamin , O’Brien Terence J. , Law Meng , Vivash Lucy
Published: October 2022

Alzheimer’s disease (AD) is a highly damaging disease that affects one’s cognition and memory and presents an increasing societal and economic burden globally. Considerable research has gone into understanding AD; however, there is still a lack of effective biomarkers that aid in early diagnosis and intervention. The recent discovery of the glymphatic system and associated Perivascular Spaces (PVS) has led to the theory that enlarged PVS (ePVS) may be an indicator of AD progression and act as an early diagnostic marker. Visible on Magnetic Resonance Imaging (MRI), PVS appear to enlarge when known biomarkers of AD, amyloid-β and tau, accumulate. The central goal of ePVS and AD research is to determine when ePVS occurs in AD progression and if ePVS are causal or epiphenomena. Furthermore, if ePVS are indeed causative, interventions promoting glymphatic clearance are an attractive target for research. However, it is necessary first to ascertain where on the pathological progression of AD ePVS occurs. This review aims to examine the knowledge gap that exists in understanding the contribution of ePVS to AD. It is essential to understand whether ePVS in the brain correlate with increased regional tau distribution and global or regional Amyloid-β distribution and to determine if these spaces increase proportionally over time as individuals experience neurodegeneration. This review demonstrates that ePVS are associated with reduced glymphatic clearance and that this reduced clearance is associated with an increase in amyloid-β. However, it is not yet understood if ePVS are the outcome or driver of protein accumulation. Further, it is not yet clear if ePVS volume and number change longitudinally. Ultimately, it is vital to determine early diagnostic criteria and early interventions for AD to ease the burden it presents to the world; ePVS may be able to fulfill this role and therefore merit further research.
Eating habits of children and adolescents during the COVID-19 era: A systematic review
Authors: Pourghazi Farzad , Eslami Maysa , Ehsani Amir , Ejtahed Hanieh-Sadat , Qorbani Mostafa
Published: October 2022

The COVID19 pandemic has affected all aspects of people's lives. Eating habit plays a crucial role in children and adolescents' physical and mental development and the impacts might last until adulthood. This systematic review aimed to summarize a comprehensive and updated overview of eating habits changes due to COVID19 confinements among children and adolescents. A systematic literature search was performed in three databases for all the English studies published from the start of the confinements until April 2022. Two researchers screened articles independently and included observational studies which evaluated children's and adolescents' eating habits before and during confinements. The quality of the included studies was assessed by Newcastle-Ottawa Quality Assessment checklists for cross-sectional and cohort studies. Among 2,436 studies, 39 final full-text articles were included. The total participants of this systematic review consist of 157,900 children and adolescents. Seven categories were identified: daily eating patterns, junk food, beverage, fruits and vegetables, milk and dairy, protein-rich foods, and legumes and cereals. In summary, most of the included studies reported a significant increase in consumption of home-cooked meals, amount of food, snack, french fries, sweets, fruits, vegetables, legumes, bread, and bakery products. On the other hand, studies demonstrated significantly lower intake of fast food and soft drink. The studies reported controversial results about breakfast consumption, sugar-added drinks, caffeinated drinks, milk and dairy products, protein-rich foods (including meat, fish, egg and chicken, and poultry), rice, and cereal. Changes in children's and adolescents' eating habits during the COVID-19 era were both positive and negative, for example, a decrease in fast food, fruit, and vegetable consumption vs. an increase in snacking and sweet consumption. Both changes have significant short-term and long-term impacts on population health. This study could provide us with insight into the changes in eating habits in children and adolescents in the COVID-19 era which we can use to limit the negative consequences on health.
Pomegranate extract supplementation improves lung function parameters and IL-35 expression in participants with mild and moderate persistent allergic asthma: A randomized, double-blind, placebo-controlled trial
Authors: Shateri Zainab , Hosseini Seyed Ahmad , Abolnezhadian Farhad , Maraghi Elham , Haddadzadeh Shoushtari Maryam , Zilaee Marzie
Published: October 2022

Existing asthma treatments are associated with side effects and limitations, which has led to an interest in alternative and complementary therapies. Given the anti-inflammatory properties of pomegranate, the present study aimed to determine the impact of pomegranate extract supplementation on lung function parameters evaluated through spirometry, high-sensitivity C-reactive protein (hs-CRP), pro-oxidant antioxidant balance, and interleukin 35) (IL-35) in participants with mild and moderate allergic asthma (based on forced expiratory volume in 1 second (FEV1) and clinical symptoms). Participants with mild and moderate allergic asthma (n = 64) were randomly assigned to two groups: the intervention group, which received two pomegranate extract capsules (500 mg/day), or the control group for eight weeks. Also, the physician prescribed similar drugs to the participants in the study. Independent samples T-test and Mann–Whitney U were used to compare the quantitative outcomes between the intervention group and the comparison group. The Wilcoxon test and the paired T-test were applied for within-group comparisons. A p-value <0.05 was considered significant. At the end of the study, the change levels of IL-35 in the intervention group increased significantly compared to the control group. In terms of the lung function parameters, FEV1/ forced vital capacity (FVC) (FEV1/FVC) ratio enhanced significantly in the intervention group compared to the control group. Also, the pomegranate extract significantly improved forced expiratory flow 25–75% (FEF25−75%), FEV1/FVC ratio, and FEV1 in the intervention group. No significant changes in FEV1 values were observed between the two groups at the end of the study. Also, no significant changes were seen in other indicators. It seems that pomegranate extract can improve lung function parameters and IL-35 expression in mild and moderate allergic asthma.

Clinical trial registration

https://www.irct.ir/trial/45612; identifier: IRCT20200205046384N1.
Prediction of cardiovascular diseases mortality- and disability-adjusted life-years attributed to modifiable dietary risk factors from 1990 to 2030 among East Asian countries and the world
Authors: Nawsherwan  , Bin Wang , Le Zhang , Mubarik Sumaira , Fu Guo , Wang Yan
Published: October 2022

Background

Unhealthy eating habits are a significant modifiable risk factor for cardiovascular diseases (CVDs); nevertheless, no evidence of their impact on the CVD burden has been reported in East Asian countries. We aimed to determine the trend and predict the future CVDs burden attributed to modifiable dietary risk factors in the East Asian countries (China, Japan, South Korea, and North Korea) and the world.

Methods

The Global Burden of Disease (GBD) 2019 data were used to find the trend of CVDs [ischemic heart disease (IHD) and ischemic stroke (IS)] mortality- and disability-adjusted life-years (DALYs) attributed to dietary risk factors in the East Asian countries and the world (1990–2019) and its prediction from 2020 to 2030. We used the joinpoint regression model and the autoregressive integrated moving average (ARIMA) model for trend and future forecast, respectively.

Results

From 1990 to 2019, regardless of sex, the age-standardized mortality rate (ASMR) and DALYs of IHD attributed to dietary risk factors significantly decreased in Japan, South Korea, and the world. However, the ASMR of IHD significantly increased in Chinese males and for both sexes in North Korea. The ASMR and DALYs of IHD and IS due to dietary risk factors were higher in males than in females in the world. From 2020 to 2030, the ASMR of IHD is predicted to increase in South Korean females and Japanese males. Globally, a diet low in whole grains was the top risk factor for the highest IHD mortality and DALYs in 2019, followed by a diet low in legumes and a diet high in sodium. A diet low in whole grains, a diet high in sodium, and a diet low in legumes were the leading risk factors for high IHD mortality in East Asian countries.

Conclusion

The trend of IHD and IS burden due to dietary risk factors varies substantially across the East Asian countries compared to the trend of CVDs burden in the world. The study findings may help the public health policymakers to design proper strategies for improvement of the quality of life to combat the CVDs burden in the future for the East Asian countries.
Evaluating the impact of pop-off mechanisms in boys with posterior urethral valves
Authors: Delefortrie T. , Ferdynus C. , Paye-Jaouen A. , Michel J. L. , Dobremez E. , Peycelon M. , El Ghoneimi A. , Harper L.
Published: October 2022

Introduction

Posterior urethral valves are urethral leaflets that cause Lower Urinary Tract Obstruction (LUTO) in boys and are associated with congenital renal dysplasia and abnormal bladder function. They affect 1:4,000 to 1:25,000 births and can be responsible for End-Stage Renal Failure in childhood. There have been several studies on the effect of pop-off mechanisms in boys with posterior urethral valves, but results are contradictory. We aimed to assess and discuss the effect of pop-off mechanisms on renal function in a large cohort of patients.

Patients and method

Boys with PUV with and without pop-off mechanisms (urinoma, VURD or giant bladder diverticula) were divided into three severity groups for renal function according to their nadir creatinine (low-risk NC < 35 μmol/L, intermediate-risk NC between 35 and 75 μmol/L, and high-risk NC > 75 μmol/L). We compared children with and children without pop-off mechanisms for mean renal function as well as patient distribution within each severity group.

Results

We included 137 boys of which 39 had a pop-off mechanism. Patients had complete data for at least 5 years follow-up. Though there was no significant statistical difference in mean renal function between the pop-off and non-pop-off group, patient distribution within each severity group varied according to whether patients had a pop-off mechanism or not.

Conclusion

Though there was no significant difference in mean renal function between boys with and without pop-off mechanisms, it is possible that these are two different patient populations and direct comparison is not possible.
Outcomes of sonographically-suspected fetal intra-abdominal cysts: Surgical intervention, conservative management and spontaneous regression
Authors: Gai Shuangshuang , Wang Lixiu , Zheng Weizeng , Xu Bin , Luo Qiong , Qin Jiale
Published: October 2022

Objective

The prenatal diagnosis of fetal intra-abdominal cysts is challenging. This study aimed to evaluate the diagnostic ability of prenatal ultrasound for fetal intra-abdominal cysts and to develop a predictive method for pre- and postnatal outcomes.

Methods

We retrospectively reviewed fetuses with ultrasound-detected intra-abdominal cysts between January 2013 and January 2020. The maternal–fetal clinical characteristics and ultrasound parameters were integrated into a model of pre- or postnatal outcomes.

Results

The study enrolled 190 eligible fetuses, including 94 cases of spontaneous regression, 33 cases of conservative management and 63 cases of surgical intervention. For the 63 cases of surgical intervention, prenatal ultrasound was found to identify fetal intra-abdominal cysts with 80.00% sensitivity (95% CI: 67.03%–89.57%), 37.50% specificity (95% CI: 8.52%–75.51%), 89.80% positive predictive value (95% CI: 83.51%–93.86%), 21.43% negative predictive value (95% CI: 8.80%–43.53%) and 74.60% accuracy (95% CI: 62.06%–84.73%). The predictive model of prenatal spontaneous regression was as follows: y = −3.291 + 0.083 × gestational age + 1.252 × initial diameter, with an area under the curve (AUC) of 0.819 (95% CI: 0.739–0.899) and an optimal cut-off value of 0.74. The large cyst diameter before delivery was an independent predictor of postnatal surgical intervention (p < 0.001), with an AUC of 0.710 (95% CI: 0.625–0.794) and an optimal cut-off value of 3.35 cm.

Conclusion

Although ultrasound has a limited ability in the accurate diagnosis of fetal abdominal cysts, a simple method of measuring the diameter can predict fetal outcomes and identify the cases that may require surgical intervention or spontaneous regression.
Stability analysis and optimal control of a time-delayed panic-spreading model
Authors: Lv Rongjian , Li Hua , Sun Qiubai , Li Bowen
Published: October 2022

In emergencies, the transmission of false and uncertain information from individual to individual causes group panic, which in turn leads to the spread of negative emotions in the group. To explore the process of panic spreading in groups, an improved panic-spreading model is constructed in this study. First, the groups are divided into the impatient group and the level-headed group, based on the theory of personality traits in psychology. Second, the logistic model is used to express the growth in the number of susceptible individuals subject to emergencies. Third, the delay effect of panic in the group can have an influence on the spread of panic. Therefore, a time-delayed panic-spreading model considering the epidemic model is established. The threshold value of the model is calculated, and the conditions for the local and global stability of the panic-free equilibrium and panic-permanent equilibrium are obtained by analyzing the dynamic behavior of the delayed-time panic model. On this basis, we choose the intensity of government measures as control variables and establish an optimal control model to minimize the spread scale. The existence and necessary conditions of the optimal solution are proved. Finally, the correctness of the conclusion is verified by numerical simulations.
Aminoacyl-tRNA synthetases in human health and disease
Authors: Turvey Alexandra K. , Horvath Gabriella A. , Cavalcanti André R. O.
Published: October 2022

The Aminoacyl-tRNA Synthetases (aaRSs) are an evolutionarily ancient family of enzymes that catalyze the esterification reaction linking a transfer RNA (tRNA) with its cognate amino acid matching the anticodon triplet of the tRNA. Proper functioning of the aaRSs to create aminoacylated (or “charged”) tRNAs is required for efficient and accurate protein synthesis. Beyond their basic canonical function in protein biosynthesis, aaRSs have a surprisingly diverse array of non-canonical functions that are actively being defined. The human genome contains 37 genes that encode unique aaRS proteins. To date, 56 human genetic diseases caused by damaging variants in aaRS genes have been described: 46 are autosomal recessive biallelic disorders and 10 are autosomal dominant monoallelic disorders. Our appreciation of human diseases caused by damaging genetic variants in the aaRSs has been greatly accelerated by the advent of next-generation sequencing, with 89% of these gene discoveries made since 2010. In addition to these genetic disorders of the aaRSs, anti-synthetase syndrome (ASSD) is a rare autoimmune inflammatory myopathy that involves the production of autoantibodies that disrupt aaRS proteins. This review provides an overview of the basic biology of aaRS proteins and describes the rapidly growing list of human diseases known to be caused by genetic variants or autoimmune targeting that affect both the canonical and non-canonical functions of these essential proteins.
Exogenous naphthaleneacetic acid alleviated alkalinity-induced morpho-physio-biochemical damages in Cyperus esculentus L. var. sativus Boeck
Authors: Ullah Abd , Zeng Fanjiang , Tariq Akash , Asghar Muhammad Ahsan , Saleem Khansa , Raza Ali , Naseer Muhammad Asad , Zhang Zhihao , Noor Javaria
Published: October 2022

Cyperus esculentusL. var. sativus Boeck (commonly called Chufa) is a perennial species that produces nutritious underground tubers and contributes to the diet and health of human worldwide. However, it is salt-sensitive and its adaptation to salinity stress remains an enigma. Naphthaleneacetic acid (NAA) plays a vital role in regulating plant salt stress tolerance. Thus, we aimed to investigate the impact of NAA (150 mg/L) application on growth and physio-biochemical response mechanisms of Chufa plants to different levels of salinity stress (0-, 90-, and 180 mM of alkaline stress ([1:1 ratio of Na2CO3and NaHCO3]). In response to increasing stress levels, shoot-root growth decreased, whereas malondialdehyde (MDA), hydrogen peroxide (H2O2), osmolytes (soluble protein, proline, and soluble sugars), and activities of superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) significantly increased. Alkalinity led to significant increase in Na+and Cl–, but decrease in Mg2+concentration in both roots and leaves; however, K+decreased significantly in leaves under both stresses. Additionally,NO3−and. levels, nitrate reductase (NR) activities, and glutamate synthase (GOGAT) decreased significantly. However, glutamine synthetase (GS) increased non-significantly at 90 mM but declined at 180 mM. Foliar NAA application reduced Na+and Cl-, MDA, and H2O2but increased photosynthetic pigments, K+and Mg2+, osmolytes, nitrogen (N) metabolism, and upregulating the enzymatic antioxidant system to reduce oxidative stress under alkaline conditions. Hence, our findings manifest that NAA application is an effective strategy that can be utilized to enhance tolerance of chufa plants to alkaline stress. Future studies should explore whether NAA can positively alter the nutrient composition of chufa tubers at deeper molecular levels, which might offer solutions to nutritious problems in developing countries.
De novo transcriptome based insights into secondary metabolite biosynthesis in Malaxis acuminata (Jeevak)–A therapeutically important orchid
Authors: Bhattacharyya Paromik , Sharma Tanvi , Yadav Abhinandan , Lalthafamkimi Lucy , Ritu  , Swarnkar Mohit Kumar , Joshi Robin , Shankar Ravi , Kumar Sanjay
Published: October 2022

Malaxis acuminata D. Don [=Crepidium acuminatum (D. Don) Szlach.] is an endangered medicinal orchid of the Ashtvarga group of plants in Ayurveda (Indian system of traditional medicine). Using a combination of aromatic cytokinin [meta-Topolin (mT)], plant biostimulant (chitosan), auxin [indole-3-butyric acid (IBA)], and a phenolic elicitor [phloroglucinol (PG)], plants of M. acuminata were regenerated in vitro for mass multiplication. The present research reveals the first-ever transcriptome of M. acuminata. A total of 43,111 transcripts encoding 23,951 unigenes were assembled de novo from a total of 815.02 million reads obtained from leaf and pseudobulb of in vitro raised M. acuminata. Expression analysis of genes associated with β-sitosterol and eugenol biosynthesis in leaf and pseudobulb provided vital clues for differential accumulation of metabolites in M. acuminata. Ultra-performance liquid chromatography (UPLC) confirmed higher amounts of β-sitosterol and eugenol content in the leaf as compared to the pseudobulb. Differential expression of transcripts related to starch and sucrose metabolism, plant hormone signal transduction, diterpenoid biosynthesis, phenylalanine metabolism, stilbenoid, diarylheptanoid, and gingerol biosynthesis suggested the operation of differential metabolic pathways in leaf and pseudobulb. The present research provides valuable information on the biosynthesis of secondary metabolites in M. acuminata, which could be used for advanced metabolite bioprospection using cell suspension culture and bioreactor-based approaches. Data also suggested that leaf tissues rather than pseudobulb can be used as an alternate source of bioactive metabolites thereby shifting the need for harvesting the pseudobulb. This will further facilitate the conservation and sustainable utilization of this highly valued medicinal orchid.
Genome-wide association study for resistance to Pseudomonas syringae pv. garcae in Coffea arabica
Authors: Ariyoshi Caroline , Sant’ana Gustavo César , Felicio Mariane Silva , Sera Gustavo Hiroshi , Nogueira Livia Maria , Rodrigues Lucas Mateus Rivero , Ferreira Rafaelle Vecchia , da Silva Bruna Silvestre Rodrigues , Resende Mário Lúcio Vilela de , Destéfano Suzete Aparecida Lanza , Domingues Douglas Silva , Pereira Luiz Filipe Protasio
Published: October 2022

Bacteria halo blight (BHB), a coffee plant disease caused by Pseudomonas syringae pv. garcae, has been gaining importance in producing mountain regions and mild temperatures areas as well as in coffee nurseries. Most Coffea arabica cultivars are susceptible to this disease. In contrast, a great source of genetic diversity and resistance to BHB are found in C. arabica Ethiopian accessions. Aiming to identify quantitative trait nucleotides (QTNs) associated with resistance to BHB and the influence of these genomic regions during the domestication of C. arabica, we conducted an analysis of population structure and a Genome-Wide Association Study (GWAS). For this, we used genotyping by sequencing (GBS) and phenotyping for resistance to BHB of a panel with 120 C. arabica Ethiopian accessions from a historical FAO collection, 11 C. arabica cultivars, and the BA-10 genotype. Population structure analysis based on single-nucleotide polymorphisms (SNPs) markers showed that the 132 accessions are divided into 3 clusters: most wild Ethiopian accessions, domesticated Ethiopian accessions, and cultivars. GWAS, using the single-locus model MLM and the multi-locus models mrMLM, FASTmrMLM, FASTmrEMMA, and ISIS EM-BLASSO, identified 11 QTNs associated with resistance to BHB. Among these QTNs, the four with the highest values of association for resistance to BHB are linked to g000 (Chr_0_434_435) and g010741 genes, which are predicted to encode a serine/threonine-kinase protein and a nucleotide binding site leucine-rich repeat (NBS-LRR), respectively. These genes displayed a similar transcriptional downregulation profile in a C. arabica susceptible cultivar and in a C. arabica cultivar with quantitative resistance, when infected with P. syringae pv. garcae. However, peaks of upregulation were observed in a C. arabica cultivar with qualitative resistance, for both genes. Our results provide SNPs that have potential for application in Marker Assisted Selection (MAS) and expand our understanding about the complex genetic control of the resistance to BHB in C. arabica. In addition, the findings contribute to increasing understanding of the C. arabica domestication history.
Information adoption behavior in online healthcare communities from the perspective of personality traits
Authors: Zhu Yiping , Jiang Hong , Zhou Zan
Published: October 2022

Improving standards of living have resulted in an increased focus on health and image management. In a context where the quality of healthcare information is unguaranteed, the adoption behavior intention of online health information varies greatly. Hence, it is essential to take effective measures to guide community users to obtain high-quality information on demand. From the perspective of personality traits, the present study analyzed the influencing factors and mechanisms of adoption behavior intention of healthcare information in online healthcare communities as well as the moderating effects of social support. A quantitative analysis of 380 respondents revealed positive associations between five personality dimensions and the adoption behavior intention of healthcare information–extraversion, agreeableness, conscientiousness, neuroticism, and openness. The study also determined that health concerns and health-related self-efficacy played a mediating role across various degrees between the conscientiousness and adoption behavior intention of healthcare information. As an important contextual factor influencing health outcomes, social support is common in online healthcare communities. The study examined the effect of the interaction between inner traits and social support on adoption behavior intention. Perceived self-esteem support strengthened the indirect effect of conscientiousness on adoption behavior intention mediated by health concerns and health-related self-efficacy. Additionally, the impact of high neuroticism interacted with low levels of perceived self-esteem support on adoption behavior intention was significant. Likewise, emotional supportive information did not help in facilitating the adoption behavior intention in terms of all five personality traits and negatively influence the adoption behavior intention for individuals high in neuroticism and agreeableness. The possible explanation for the results was discussed with the intention of understanding the psychological mechanisms which guide adoption behavior intention.
Get to grips with motivation: Slipping and gripping movements are biased by approach-avoidance context
Authors: Nilsson Sofie Johanna , Meder David , Madsen Kristoffer Hougaard , Toni Ivan , Siebner Hartwig Roman
Published: October 2022

People are better at approaching appetitive cues signaling reward and avoiding aversive cues signaling punishment than vice versa. This action bias has previously been shown in approach-avoidance tasks involving arm movements in response to appetitive or aversive cues. It is not known whether appetitive or aversive stimuli also bias more distal dexterous actions, such as gripping and slipping, in a similar manner. To test this hypothesis, we designed a novel task involving grip force control (gripping and slipping) to probe gripping-related approach and avoidance behavior. 32 male volunteers, aged 18–40 years, were instructed to either grip (“approach”) or slip (”avoid”) a grip-force device with their right thumb and index finger at the sight of positive or negative images. In one version of this pincer grip task, participants were responding to graspable objects and in another version of the task they were responding to happy or angry faces. Bayesian repeated measures Analysis of variance revealed extreme evidence for an interaction between response type and cue valence (Bayes factor = 296). Participants were faster to respond in affect-congruent conditions (“approach appetitive,” “avoid aversive”) than in affect-incongruent conditions (“approach aversive,” “avoid appetitive”). This bias toward faster response times for affect-congruent conditions was present regardless of whether it was a graspable object or a face signaling valence. Since our results mirror the approach and avoidance effects previously observed for arm movements, we conclude that a tendency favoring affectively congruent cue-response mappings is an inherent feature of motor control and thus also includes precision grip.
Community public health safety emergency management and nursing insurance service optimization for digital healthy urban environment construction
Authors: Hu Guosheng , Wang Zeyu , Jiang Shaoxiang , Tian Yuan , Deng Yue , Liu Yang
Published: October 2022

The purpose of this paper is to promote the construction of digital healthy cities and improve the living standards of urban residents. Based on this, this paper analyzes the development of healthy cities, and studies community public health safety emergency management and nursing insurance service optimization methods for healthy urban environment construction. First, the concept of digital healthy urban environment construction is discussed. Then, the role of environmental health is discussed. Finally, two methods are designed to study the emergency management of public health safety and nursing insurance services in urban communities under the condition of environmental health. The results show that in the environmental health score of the city, the scores of X1 (the urban air quality excellent rate) and X6 (citizens' satisfaction with the environmental quality) were relatively low between 2016 and 2018, below 0.5 points. The scores for the remaining 3 years were relatively high, above 0.5. The scores of X2 (green coverage rate of built-up area), X3 (average grade sound effect of environmental noise in urban area), X4 (harmless treatment rate of domestic waste) and X5 (centralized treatment rate of domestic sewage) were relatively high from 2016 to 2018, above 0.5 points, and relatively low in the remaining 3 years, below 0.5 points. Meanwhile, residents are very satisfied with information collection and information management in public health and safety emergency management, and the number of very satisfied people is basically more than 40%. Satisfaction with resource allocation and privacy management is high, and the number of very satisfied people is basically above 30%. However, the satisfaction with risk perception and management measures is very low, and the number of very satisfied people is basically below 20%. It shows that the current construction of the community's public health and safety emergency management system is relatively poor in terms of X2–X5, while the development of X1 and X6 is relatively mature. The research not only provides a reference for the construction and improvement of a digital healthy city, but also contributes to the improvement of the healthy life of urban residents.
Simulation and forecasting models of COVID-19 taking into account spatio-temporal dynamic characteristics: A review
Authors: Wang Peipei , Zheng Xinqi , Liu Haiyan
Published: October 2022

The COVID-19 epidemic has caused more than 6.4 million deaths to date and has become a hot topic of interest in different disciplines. According to bibliometric analysis, more than 340,000 articles have been published on the COVID-19 epidemic from the beginning of the epidemic until recently. Modeling infectious diseases can provide critical planning and analytical tools for outbreak control and public health research, especially from a spatio-temporal perspective. However, there has not been a comprehensive review of the developing process of spatio-temporal dynamic models. Therefore, the aim of this study is to provide a comprehensive review of these spatio-temporal dynamic models for dealing with COVID-19, focusing on the different model scales. We first summarized several data used in the spatio-temporal modeling of the COVID-19, and then, through literature review and summary, we found that the existing COVID-19 spatio-temporal models can be divided into two categories: macro-dynamic models and micro-dynamic models. Typical representatives of these two types of models are compartmental and metapopulation models, cellular automata (CA), and agent-based models (ABM). Our results show that the modeling results are not accurate enough due to the unavailability of the fine-grained dataset of COVID-19. Furthermore, although many models have been developed, many of them focus on short-term prediction of disease outbreaks and lack medium- and long-term predictions. Therefore, future research needs to integrate macroscopic and microscopic models to build adaptive spatio-temporal dynamic simulation models for the medium and long term (from months to years) and to make sound inferences and recommendations about epidemic development in the context of medical discoveries, which will be the next phase of new challenges and trends to be addressed. In addition, there is still a gap in research on collecting fine-grained spatial-temporal big data based on cloud platforms and crowdsourcing technologies to establishing world model to battle the epidemic.
Payday lenders and premature mortality
Authors: Agnew Megan , Bea Megan Doherty , Friedline Terri
Published: October 2022

Relationships between debt and poor health are worrisome as access to expensive credit expands and population health worsens along certain metrics. We focus on payday lenders as one type of expensive credit and investigate the spatial relationships between lender storefronts and premature mortality rates. We combine causes of death data from the Centers for Disease Control and Prevention (CDC) and payday lender locations at the county-level in the United States between 2000 and 2017. After accounting for county socioeconomic and demographic characteristics, the local presence of payday lenders is associated with an increased incidence risk of all-cause and specific-cause premature mortality. State regulations may attenuate these relationships, which provides insights on policy strategies to mitigate health impacts.
Effects of pleasant sound on overnight sleep condition: A crossover randomized study
Authors: Saeda Shota , Fujiwara Koichi , Kinoshita Takafumi , Sumi Yukiyoshi , Matsuo Masahiro , Yamaki Kiyoshi , Kawashima Takahiro , Kadotani Hiroshi
Published: October 2022

It is desirable to improve sleep quality since poor sleep results in decreases in work productivity and increases in risks of lifestyle-related diseases. Sleep spindles in sleep EEG are waveforms that characterize non-REM sleep Stage 2 (Stage N2). Music therapy has been adopted as a non-pharmacological therapy for sleep quality improvement; however, few studies mention the relationship between music during sleep and spindles. We conducted a crossover randomized study to investigate music's effects on spindles and sleep parameters. Polysomnography (PSG) was performed on 12 adult males with sleep difficulties over three nights, during which they were exposed to three different acoustic environments–silent, white noise, and pleasant sounds–throughout the night, in a crossover randomized setting. Half of the participants with large WASO were defined as the sleep maintenance difficulty group. We investigated whether pleasant sounds shortened sleep onset latency (SOL) and increased the number of spindles (SN) and spindle density (SD) compared to white noise, using silent as the reference. The spindles were detected using the previously reported automatic spindle detection algorithm. After one patient was excluded due to data corruption, a total of 11 participants, including the sleep maintenance difficulty group (n = 5), were analyzed. For all participants, SOL was not significantly shorter with pleasant sound than with white noise (p = 0.683); for the sleep maintenance difficulty group, SOL tended to be shorter with pleasant sound than with white noise (p = 0.060). Compared to white noise, the SN increased in pleasant sound for 7 of 11 (4 of 5 in the sleep maintenance difficulty group), and SD increased for 5 of 11 (3 of 5 in the sleep maintenance difficulty group). The results suggest that all-night background sound exposure may affect SN and SD. Future research should investigate whether background sound exposure reduces sleep-related distress, achieves sound sleep, or improves daytime psychomotor function.
High-throughput generation of microfluidic-templating microgels for large-scale single-cell encapsulation
Authors: Zhang Haoyue , Li Chengze , Zhang Yujie , An Chuanfeng , Li Hanting , Yu Jiahui , Zhang Yonghao , He Wei , Wang Huanan
Published: October 2022

Microfluidics-based fabrication of cell-laden microgels has shown great potential for applications in cell therapy and tissue engineering, however, the difficulty in chip operation and compromised cell viability due to cell sedimentation and channel blockage remain a major challenge for functional cell-laden microgels preparation. Herein, we presented the design and optimization of integrated microfluidic chip for large-scale preparation of cell-laden microgels with controllable size and complex microstructure. Specifically, to avoid severe cell sedimentation and uneven distribution in the parallelized microchannel, we simulated cell movement state using computational fluid dynamics simulation. It was found that higher laminar flow velocity gradient and higher precursor viscosity can significantly improve the uniform cell distribution in parallelized channels and reduce the product difference between channels. Moreover, we designed multiple-layered microfluidic chips allowing multiple inputting liquids for the fabrication of microgels with complex structures. This integrated chip facilitated cell encapsulation at a maximum production rate of 240 ml/h of cell suspension with retained cell viability and functionality. Therefore, our study provided a biocompatible and high-throughput strategy for large-scale preparation of cell-laden microgels, which can enable significant advances for clinical-relevant applications of cell-laden microgels, including cell therapy, tissue regeneration and 3D bioprinting.
Eccentric distance zone analysis system: New regional evaluation of cephalic fixator tip location for predicting cut-out in geriatric intertrochanteric fractures with internal fixation
Authors: Yang Yun-fa , Huang Jian-wen , Gao Xiao-sheng , Xu Zhong-he
Published: October 2022

Objective

The aim of this study was to investigate an eccentric distance (ED) zone analysis system for regional evaluation of the cephalic fixator tip based on the ED of the cephalic fixator tip referenced to the radius of its own femoral head to predict cut-out in intertrochanteric fractures (ITF) with internal fixation.

Methods

First, we assumed all the femoral heads were regular spheres with the radius (RFD) of “3” for a complete match of the Cleveland zone system and calculated the ED of the cephalic fixator tip by measuring the distances from the cephalic fixator tip to the geometric central axis in the femoral neck and head on both anteroposterior (AP) view and lateral view radiographs. Second, we defined the maximum transverse section of the femoral head into three zones named ED Zone A with ED less than “1,” Zone B with ED ranging in “1–2,” and Zone C with ED ranging in “2–3” in turns by concentric circles (circles A, B, and C) with the radius of 1/3, 2/3, and 3/3 times of RFD, respectively. Third, we evaluated the ED zones according to the ED and location of the cephalic fixator tip in the eligible 123 ITF patients with single-screw cephalomedullary nail (SCMN) fixation and then analyzed the correlation between the cut-out rate and the ED zones.

Results

The cut-out rates in ED Zones A, B, and C were 4.17%, 38.46%, and 100%, respectively. Multivariate logistic regression indicated that ED Zone A had at least a 14 times lower rate of cut-out compared with ED Zone B. The cephalic fixator tip located in ED Zone A has a lower cut-out rate than that in Cleveland Zone 5. The cut-out rate in ED Zone A is significantly lower than that in the region inside Cleveland Zone 5 but outside ED Zone A.

Conclusion

ED zone analysis system is a reliable regional evaluation of the cephalic fixator tip position for predicting cut-out in geriatric ITF patients with SCMN fixations and potentially an artificial intelligence measurement during surgery. For decreasing the cut-out rate, the cephalic fixator tip should be located in ED Zone A.
Primary intraosseous meningioma with subcutaneous and dural invasion: A case report and literature review
Authors: Zou Mingang , Yang Ruijin , Tang Zhiji , Luo Defang , Jiang Qiuhua
Published: October 2022

Primary intraosseous meningiomas (PIOMs) are a rare subset of meningiomas, comprising fewer than 1% of all such tumors. Furthermore, PIOMs presenting as osteogenic lesions that invade both the dura and subcutaneous tissue are extremely rare. Unlike intracranial meningiomas, diagnosing and treating PIOMs are challenges due to their insidious clinical behavior and a lack of clear radiological diagnostic criteria. We report the case of a 60-year-old female with headache and a slightly outward protrusion of the parietal region of the skull. CT showed an osteogenic lesion in the right parietal bone. MR imaging indicated mild to moderate homogeneous enhancement with an intense dural reaction. The suggested clinical diagnosis was lymphoma, so we performed a skull biopsy, which revealed an intraosseous benign meningioma. A precise resection strategy was planned with a neuronavigation system accompanied by a one-step customized titanium mesh cranioplasty. The lesion was completely removed, and pathological analysis confirmed a meningothelial meningioma (WHO Grade I) of intraosseous layer origin invading the dura mater and subcutaneous tissue. This case highlights the need for an initial biopsy when the lesion is difficult to diagnose on imaging. Complete resection should be attempted to minimize the risk of recurrence.
Metric for Structural Complexity Assessment of Space Systems Modeled Using the System Modeling Language
Authors: Lopez Victor Emmanuel Pierre , Thomas Lawrence Dale
Published: October 2022

A complexity metric is proposed for the quantification of system complexity using information about the composition of a system and its interactions depicted in a System Modelling Language (SysML) model. The proposed metric is adapted from the complexity metric developed for design structure matrix (DSM) applications and was modified to allow the metric to be applied at different decomposition levels and to accommodate the inclusion of external interactions. The metric was applied to three case studies: a Mars lander, a CubeSat and a spacecraft thermal control system. The proposed metric attributed a higher amount of complexity due to the interactions compared to the DSM metric. This variance resulted in instances where the results differed for the two metrics. Despite these differences, both metrics behaved similarly to changes in component or interaction complexity.
Visual Navigation Algorithm for Night Landing of Fixed-Wing Unmanned Aerial Vehicle
Authors: Wang Zhaoyang , Zhao Dan , Cao Yunfeng
Published: October 2022

In the recent years, visual navigation has been considered an effective mechanism for achieving an autonomous landing of Unmanned Aerial Vehicles (UAVs). Nevertheless, with the limitations of visual cameras, the effectiveness of visual algorithms is significantly limited by lighting conditions. Therefore, a novel vision-based autonomous landing navigation scheme is proposed for night-time autonomous landing of fixed-wing UAV. Firstly, due to the difficulty of detecting the runway caused by the low-light image, a strategy of visible and infrared image fusion is adopted. The objective functions of the fused and visible image, and the fused and infrared image, are established. Then, the fusion problem is transformed into the optimal situation of the objective function, and the optimal solution is realized by gradient descent schemes to obtain the fused image. Secondly, to improve the performance of detecting the runway from the enhanced image, a runway detection algorithm based on an improved Faster region-based convolutional neural network (Faster R-CNN) is proposed. The runway ground-truth box of the dataset is statistically analyzed, and the size and number of anchors in line with the runway detection background are redesigned based on the analysis results. Finally, a relative attitude and position estimation method for the UAV with respect to the landing runway is proposed. New coordinate reference systems are established, six landing parameters, such as three attitude and three positions, are further calculated by Orthogonal Iteration (OI). Simulation results reveal that the proposed algorithm can achieve 1.85% improvement of AP on runway detection, and the reprojection error of rotation and translation for pose estimation are 0.675∘ and 0.581%, respectively.