bluuebunny/crossref_metadata_2025 huggingface dataset:
Cooperation of Various Cytoskeletal Components Orchestrates Intercellular Spread of Mitochondria between B Cells through Tunnelling Nanotubes
Authors: Halász Henriett , Tárnai Viktória , Matkó János , Nyitrai Miklós , Szabó-Meleg Edina
Published: January 2024

Membrane nanotubes (NTs) are dynamic communication channels connecting spatially separated cells even over long distances and promoting the transport of different cellular cargos. NTs are also involved in the intercellular spread of different pathogens and the deterioration of some neuro-logical disorders. Transport processes via NTs may be controlled by cytoskeletal elements. NTs are frequently observed membrane projections in numerous mammalian cell lines including various immune cells, but their functional significance in the ‘antibody factory’ B cells is poorly elucidated. Here we report that as active channels, NTs of B cells can mediate bidirectional mitochondrial transport, promoted by the cooperation of two different cytoskeletal motor proteins, kinesin along microtubules and myosin VI along actin, and bidirectional transport processes are also supported by the heterogeneous arrangement of the main cytoskeletal filament systems of the NTs. We revealed that despite NTs and axons being different cell extensions the mitochondrial transport they mediate may exhibit significant similarities. Furthermore, we found that microtubules may improve the stability and lifespan of B cell NTs, while F-actin strengthens NTs by providing a structural framework for them. Our results may contribute to a better understanding of the regulation of the major cells of humoral immune response to infections.
Clinical, Laboratory, Imaging and Electrocardiographic Differences between Patients with Lyme Disease and Patients with Lyme Disease and B. divergens Antibodies
Authors: Folgueras María , Gonzalez Luis Miguel , Collazos Julio , Rodríguez-Pérez Mercedes , Pérez-ls Laura , Diaz-Arias Javier , Meana María , Revuelta Belen , Montero Estrella , Asensi Víctor
Published: January 2024

Clinical and diagnostic tests differences between adult patients monoinfected with Borrelia burgdorferi sensu lato (s.l.) and patients infected with B. burgdorferi s.l. who also had IgG antigens against Babesia divergens have not been reported so far. Both Lyme disease caused by B. burgdorferi and babesiosis caused by B. divergens, endemic in Northwestern Spain, are transmitted by Ixodes tick bites.

Clinical, laboratory and other diagnostic tests characteristics (imaging, electrocardiographic-ECG) of 120 residents of Northwestern Spain with B. burgdorferi s.l. infection, diagnosed during 2015-2017, of whom 47 (39.2%) had B. divergens IgG antibodies, were retrospectively compared.

Cardiorespiratory symptoms were reported in 9/47 (19.2%) patients with Lyme disease and B. divergens IgG antibodies compared to 4/73 (5.5%) patients with B. burgdorferi s.l. monoinfection (P=0.02). Dyspnea was recorded in 4/47 (8.5%) patients with Lyme disease and B. divergens IgG antibodies compared to 1/73 (1.4%) monoinfected patients (P=0.07). In addition ECG atrioventricular (AV) block was detected in 5/47 (15.6%) patients with Lyme disease and B. divergens IgG antibodies compared to 1/73 (2.6%) monoinfected individuals (P=0.09). No other clinical, laboratory or other tests differences were observed between doubly infected and monoinfected patients.

We conclude that patients with Lyme disease and B. divergens IgG antibodies had more frequently cardiorespiratory symptoms, mostly dyspnea, compared to monoinfected individuals. These symptoms were unrelated to anemia. ECG AV block perhaps induced by summative myocardial damage due to both infections might play some role in the cardiorespiratory dysfunction.
Electroacupuncture Reduces Fibromyalgia Pain via Neuronal/Microglial Inactivation and Toll-Like Receptor 4 in the Mouse Brain: Precise Interpretation of Chemogenetics
Authors: Tsai Sheng-Ta , Yang Chia-Chun , Liao Hsien-Yin , Lin Yi-Wen
Published: January 2024

Fibromyalgia (FM) is a complex, chronic, widespread pain syndrome that can cause significant health and economic burden. Emerging evidence has shown that neuroinflammation is an underlying pathological mechanism in fibromyalgia. Toll-like receptors (TLRs) are key mediators of the immune system. TLR4 is expressed primarily in microglia and regulates downstream signaling pathways, such as MyD88/NF-κB and TRIF/IRF3. It remains unknown whether electroacupuncture (EA) has therapeutic benefit in attenuating fibromyalgia pain and what role the TLR4 pathway may play in this effect. We compared EA with sham EA to eliminate the placebo effect due to acupuncture. We demonstrated that intermittent cold stress significantly induced an increase in mechanical and thermal FM pain in mice (mechanical: 2.48 ± 0.53 g; thermal: 5.64 ± 0.32 s). EA but not sham EA has analgesic effect on FM mice. TLR4 and inflammatory mediators-related molecules were increased in FM mice’s thalamus, medial prefrontal cortex, somatosensory cortex, and amygdala, indicating neuroinflammation and microglial activation. These molecules were reduced by EA but not sham EA. Furthermore, a new chemogenetics method was used to precisely inhibit SSC activity displayed an anti-nociceptive effect through TLR4 pathway. Our results imply that the analgesic effect of EA is associated with TLR4 downregulation. We provide novel evidence that EA can modulate the TLR4 signaling pathway, revealing potential therapeutic targets for FM pain.
A Comparative Analysis of the Pension Schemes for Elderly Population in Developing Countries: Policy Insights in the Context of financial wellbeing and social justice
Authors: Khai Tual Sawn , Jacob Nkansah Oppong , Khan Abdul Wali , Asaduzzaman Muhammad
Published: January 2024

The rapid growth of the elderly population is a major global demographic and social issue. Unfortunately, there is a shortage of pension plans and social se-curity programmes for this population in developing countries which has severe consequences for their quality of life and planetary health (PH) wellbeing. In this article, we aimed to better understand the pension systems in Ghana, Pakistan, and Myanmar, by reviewing the official government materials (such as pension reports) and published literature. We observed several policy implementation gaps and inequity in pension schemes for older people, specifically for informal and private sector workers. Considering the size of formal versus informal economies and the level of development index of each country, we suggest a wide variety of options in pension policies, financing, designing cash benefits and pension payments to cover all older citizens. This article addresses an unmet need of the elderly people, their wider environmental and economic sustainability to ensure social justice and resource utilization. The governments of developing countries should embrace and establish unique, inclusive, and friendly policies encompassing the informal sector to warrant older adults’ functional and planetary wellbeing with dignity and honor.
Provably secure ECC-based anonymous authentication and key Agreement for IoT
Authors: Hu Shunfang , Jiang Shaoping , Miao Qing , Yang Fan , Zhou Weihong , Duan Peng
Published: January 2024

With the rise of the Internet of Things (IoT), maintaining data confidentiality and protecting user privacy have become increasingly challenging. End devices in IoT are often deployed in unattended environments and connected to open networks, which can make them vulnerable to physical tampering and other security attacks. Different authentication key agreement (AKA) schemes have been validated to date, but most schemes do not cover the necessary security features or are incompatible with resource-constrained end devices. Besides, their security proofs have been performed under the real-or-random model, which is not guaranteed to be secure in real applications. To reduce the weaknesses, we present an AKA protocol for end devices and servers. The proposal leverages the ECC-based key exchange mechanism and one-way hash function-based message authentication method to achieve mutual authentication, user anonymity, and forward security. Formal security proof of the proposed scheme is performed under the standard model with the elliptic curve encryption computational assumptions, and an automatic formal verification was performed with ProVerif. Further, the performance comparison verifies that our scheme reduces computation and communication costs while providing improved security features.
Real-Time Performance Benchmarking of RISC-V Architecture: Implementation and Verification on an EtherCAT-Based Robotic Control System
Authors: Yoo Taeho , Choi Byoung Wook
Published: January 2024

RISC-V offers a modular technical approach combined with an open, royalty-free instruction set architecture (ISA). This openness allows various researches to incorporate RISC-V into both open and proprietary solutions or services. However, despite its advantages as a fundamental building block for many embedded systems, the escalating complexity and functional demands of real-time applications have made adhering to response time deadlines challenging. This has led to an increased demand for comprehensive development insights for real-time systems based on RISC-V. To improve development efficiency, we offer a detailed performance analysis of RISC-V in comparison to various ISAs. In this paper, we analyze the real-time performance of RISC-V through two real-time approaches based on processor architectures. For RTOS applications, we adopted FreeRTOS and evaluated its performance on HiFive1 Rev B (RISC-V) and STM3240G-EVAL (ARM M) to evaluate real-time performance. For Real-time Linux, we utilized Linux with the Preempt-RT patch and tested its performance on VisionFive 2 (RISC-V), MIO5272 (x86-64), and Raspberry Pi 4 B (ARM A). Through these experiments, we examined the real-time mechanism of each operating system. Additionally, in the Preempt-RT experiments, scheduling latencies were evaluated using cyclictest. Finally, in order to practically show the real-time capabilities of RISC-V, we implemented motion control of a six-axis collaborative robot, which was performed on the VisionFive 2 platform. This implementation provided a comparative result of RISC-V’s performance against the x86-64 architecture of MIO-5272. Ultimately, the results indicated that the real-time performance of RISC-V for real-time applications was slightly inferior to that of the x86-64 architecture. A noticeable achievement of this research was the first implementation of an EtherCAT Master on RISC-V designed for real-time applications featuring a multi-tasking structure. The research offers valuable insights into the real-time capabilities of RISC-V compared to established architectures like x86-64. While RISC-V might not surpass these architectures in real-time performance, its flexibility, modularity, and open nature make it a compelling choice for a wide range of real-time applications. The successful implementation of the EtherCAT Master on RISC-V further expands its potential in the domain of real-time embedded control systems.
Potential Rheumatoid Arthritis-Associated Interstitial Lung Disease Treatment and Computational Approach for Future Drug Development
Authors: Jeong Eun Ji , Hong Hyunseok , Kim Kyoung-Soo
Published: January 2024

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by swelling in at least one joint. Owing to an overactive immune response, extra-articular manifestations are observed in certain cases, with interstitial lung disease (ILD) being the most common. Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is characterized by chronic inflammation of the interstitial space, which causes fibrosis and the scarring of lung tissue. Controlling inflammation and pulmonary fibrosis in RA-ILD is important because they are associated with high morbidity and mortality. Pirfenidone and nintedanib are specific drugs against idiopathic pulmonary fibrosis and have shown efficacy against RA-ILD in several clinical trials. Immunosuppressants and disease-modifying antirheumatic drugs (DMARDs) with antifibrotic effects have also been used to treat RA-ILD. Immunosuppressants moderate the overexpression of cytokines and immune cells to reduce pulmonary damage and slow the progression of fibrosis. DMARDs with mild antifibrotic effects target specific fibrotic pathways to regulate fibrogenic cellular activity, extracellular matrix homeostasis, and oxidative stress levels. Therefore, specific medications are required to effectively treat RA-ILD. In this review, the commonly used RA-ILD treatments are discussed based on their molecular mechanisms and clinical trial results. In addition, a computational approach is proposed to develop specific drugs for RA-ILD.
Planning Implications of the Effect of Crude Oil Pollution on Germination and Growth Parameters of Mucuna Pruriens (Var Cochinchinesis) Fabacea in Rivers State, Nigeria
Authors: Brown Ibama , Ogboeli Goodluck Prince
Published: January 2024

The effect of varying concentrations of crude oil pollution on the germination and growth parameters of Mucuna pruriens (Var. cochinchinenesis) was investigated. The following treatments were used; 0ml, 100ml, 200ml, 400ml, 800ml 1600ml respectively. The germination of velvet bean was 100% but growth was found to be inhibited by a wide range of treatments (800ml and 1600ml). the lag phase of proceeding growth is also reduced at this treatment. Growth inhibition is attributed primarily to the characteristics of oil, which acts as a physical barrier to water and oxygen uptake. Reduction in the growth and development of plants was observed in the polluted treatments as against the control (non–polluted treatment) because of the deleterious effect of the petroleum products on the morphological parameters (plant height, number of leaves and leaf area) tested for. Velvet beans treated with lower treatment (100ml and 200ml) were observed to be more productive when compared to the control experiment. Consequently, as the crude oil exceeds the plant absorbing capacity at 800ml and 1600ml respectively, the growth retards, chlorosis, presence of tough apical meristem, and defoliation from the base of the plant.
Current Literature Review of COVID Eye Infections in the Pediatric Population and the Beneficial Effect of Isolated Treatment of COVID Uveitis (Panuveitis) in a Child after Isolated Administration of Depomedrol under the Tenon Capsule — a Case Report
Authors: Modrzejewska Monika , Cyrankiewicz Joanna , Zdanowska Oliwia , Bosy-Gąsior Wiktoria
Published: January 2024

Coronavirus disease 2019 (COVID-19), can manifest with ocular symptoms. These symptoms can be divided into isolated events attributed to COVID-19 and those occurring in multisystem inflammatory syndrome in children (MIS-C), a newly diagnosed disease entity associated with COVID-19 infection. Currently, the literature lacks specific guidelines and treatment regimens for COVID-19 ocular symptoms, especially in children.
Socioeconomic Deprivation Is Associated with Worse Outcomes after Adult Liver Transplantation
Authors: De Simone Paolo , Bronzoni Jessica , Lai Quirino , Martinelli Caterina , Ducci Juri , Campani Daniela , Gitto Stefano , Marchetti Piero
Published: January 2024

Background and Aims: The present study analyzed retrospectively the association between socioeconomic deprivation and graft and patient survival in a cohort of 2,568 adult recipients of a liver transplant between 1996 and 2022.
Materials and methods: The primary exposure was a nationally validated socioeconomic deprivation index (DI) at census block level and ranking from 1-5, with higher ranks indicating more significant socioeconomic deprivation.
Results: At a median (IQR) follow-up of 144.8 (204) months, the overall patient and graft survival rates were 92% and 90.4% at 1 year, 78.4% and 72.2% at 5 years, and 58% and 56.7% at 10 years. Recipients with a DI rank above the median (i.e., more deprived) had 1, 5, and 10-year patient and graft survival rates of 91% and 89.5%, 70.4% and 68.4%, 48% and 46.7%, respectively, versus 92% and 90.4%, 78.4% and 72.2%, and 58% and 56.7% for less deprived patients (log-rank p<0.001). More deprived patients had a higher risk of death (p<0.0001), hypertension (p<0.0001), obesity (p=0.02), diabetes mellitus (p=0.02), graft rejection (p<0.0001), chronic kidney dysfunction (p<0.0001), major cardiovascular events (p<0.0001) and de novo malignancies (p<0.0001) than less deprived recipients. The factors associated with the survival probability were younger donor and recipient ages (p=0.03 and 0.02, respectively), female recipient sex (p=0.04), absence of HCV (p<0.01), absence of HCC (p=0.02), absence of DM at transplantation (p=0.03) and 1 year (p=0.01), lower DI (p=0.02), lower MELD (0.02), shorter CIT (p=0.03), TAC (p=0.01), and EVR in the immunosuppressive regimen (p=0.02).
Conclusions: Patients from more deprived areas have a higher risk of death after liver transplantation. Pre- and post-transplant socioeconomic risk profiling is warranted to better tailor care to patient’s needs and expectations.
Effects of Fertilization Patterns on the Growth of Rapeseed Seedlings and Rhizosphere Microorganisms under Flooding Stress
Authors: Wu Xuepeng , Wu JJ , Zhou Bingqian , Hong Bo , Zhao Dongfang , Guan Chunyun , Guan Mei
Published: January 2024

In order to explore the effect of fertilization patterns on the growth of rapeseed seedlings under waterlogging stress, three fertilization patterns (conventional fertilization, supplemental organic fertilization, and supplemental microbial fertilization) were set up using the variety Xiangyou 708 as the material, and waterlogging treatment was carried out during the seedling stage of rapeseed. The effects of fertilization patterns on the growth of rapeseed seedlings and rhizosphere microorganisms under waterlogging stress were investigated. The results showed that all three fertilization patterns exhibited that waterlogging stress inhibited the growth of rapeseed seedlings, inhibited root activity, and changed the structure of rhizosphere bacterial colonies. However, supplemental organic fertilization and microbial fertilization could better promote the growth of rapeseed seedlings, reduce the impact of waterlogging stress on the growth of rapeseed seedlings, and accelerate the recovery of rapeseed seedlings after waterlogging stress. In addition, supplemental microbial fertilization could also change the structure of rhizosphere bacterial colonies. Under normal water supply, supplemental organic fertilization enriched P_Bacteroidota, P_Actinobacteriota, P_Chloroflexi, and G_Flavisolibacter in the rhizosphere soil of rapeseed, while supplemental microbial fertilization enriched P_Bacteroidota and G_Flavisolibacter in the rhizosphere soil of rapeseed. After 7 days of waterlogging treatment, supplemental organic fertilization enriched P_Verrucomicrobiota in the rhizosphere soil of rapeseed, while supplemental microbial fertilization enriched P_Actinobacteriota, G_SC-I-84, and G_Ellin6067 in the rhizosphere soil of rapeseed. The enrichment of these bacteria may be related to the growth promotion and waterlogging tolerance of rapeseed. This study provides evidence that microbial fertilizer and organic fertilizer can promote the growth of rapeseed and enhance its waterlogging tolerance, as well as evidence that some rhizosphere microorganisms have a potential role in promoting the growth and waterlogging tolerance of rapeseed.
Interprofessional Collaboration in Primary Care Practices during the COVID-19 Pandemic In Switzerland
Authors: El hakmaoui Fatima , Schuetz Muriel , Scuderi Renzo , Senn Nicolas , Cohidon Christine
Published: January 2024

Background: There is a lack of knowledge about how nurses and general practitioners (GPs) collaborated during the COVID-19 pandemicin primary care settings. Our study examined the roles of primary care nurses during the pandemic’s first wave, between March and June 2020, in Switzerland. Methods: The study involved all eight general practices implementing of a nursing role to the practice’s team. Primary care practice staff members (nurses, GPs and medical assistants) have been involved on the development of a new organizational model. A mixed-methods design study collected quantitative data using daily activity monitoring and an electronic survey. Additionally, eight nurses and nine GPs participated in a focus group discussion and individual interviews. Results: GPs recognized the substantial contributions, versatility, and autonomy of the primary care nurses in their practices during the pandemic. Those nurses experienced their involvement positively, mainly thanks to their perceived autonomy. The distribution of activities between primary care practice professionals was heterogenous due to extrinsic and intrinsic factors. Conclusion: Both nurses and GPs agreed that there was added value in having primary care nurses ingeneral practices in time of crisis, and this agreement will bolster plans to integrate this workforce across the canton. The development of nurses’ roles in primary care during the pandemic was reliant on many factors, including practice organization and Switzerland’s healthcare reimbursement and payment system
Sustainable and Optimized Production in an Aluminum Extrusion Process
Authors: Ferrá Filipe , Correia Aldina , De Almeida Fátima , Costa e Silva Eliana
Published: January 2024

In the discussion on environmental policies, the notion of eco-efficiency is often used. Eco-efficiency is defined as the delivery of products and services with competitive values, while reducing the ecological impacts and satisfying human needs. In an environment of great competitiveness in which the companies operate, the improvements in the productive process is one of the differentiating factors for guaranteeing a strong competition. Also it is essential rationalizing energy consumption and natural resources. For this it is necessary to understand the main operations and dynamics of the company. This work presents an empirical study of a Portuguese company in the industrial sector. The problematic here presented is based on the company’s growing concern to reduce the amount of scrap produced. From the literature research that was performed, a strong dependence relation between the different variables in the extrusion process was found. The main objective of this work is to model the aluminium extrusion process, with the aim of minimizing the production of scrap. For this several variables involved in the process are taking into account. Using statistical techniques, in particular multiple linear regressions, it was possible to identify the importance of the variables under study for the scrap production.
Current Evidence of Natural Products Against Overweight and Obesity: Molecular Targets and Mechanisms of Action
Authors: Elizalde-Romero Cristina Alicia , Leyva-López Nayely , Contreras-Angulo Laura Aracely , Cabanillas-Ponce de León Rigoberto , Rodriguez-Anaya Libia Zulema , León-Félix Josefina , Heredia J. Basilio , Beltrán-Ontiveros Saúl Armando , Gutiérrez-Grijalva And Erick Paul
Published: January 2024

Overweight and Obesity are global health and economic concerns. According to the World Health Organization, the number of individuals with obesity has nearly tripled since 1975. This health issue is currently considered an epidemic, affecting over 1.9 billion adults and 340 million children and adolescents. It contributes to more than 5 million deaths each year and has a global economic burden that will reach $4.32 trillion annually by 2035, according to the World Obesity Federation. This disease can affect every system of the human body and can lead to complications such as metabolic syndrome, diabetes, cancer, dyslipidemia, cardiovascular diseases, and hypertension, among others. Treatment may sometimes include diet, exercise, drugs, and bariatric surgery. Nonetheless, not all people have access to these treatments, and public health strategies consider prevention the most important factor. In this regard, recent investigations are aiming to find alternatives and adjuvants for the treatment of obesity, its prevention, and the reversion of some of its complications, using natural sources of anti-obesogenic compounds like polyphenols, terpenes, alkaloids, saponins, among others. In this review, we gather the most current information using PubMed, Google Scholar, Scopus, Cochrane, and Web of Science. We present and discuss the current information about natural products that have shown anti-obesogenic effects at a molecular level. We also consider the impact of dietary habits and lifestyle in preventing overweight and obesity due to the evidence of the benefits of certain foods and compounds consumed regularly. We discuss mechanisms, pathways, and receptors involved in the modulation of obesity, especially those related to inflammation and oxidative stress linked to this disease, due to the relevance of these two aspects in developing complications.
Info- Geometric Analysis of the Stable Queue Manifold Dynamics With Queue Applications to E-health
Authors: A Mageed Dr Ismail
Published: January 2024

Information geometry is a mathematical framework that analyses the structure of statistical models using concepts from differential geometry. It treats families of probability distributions as manifolds, where the parameters of each model determine the coordinate charts. By applying info-geometric tools, we can gain insights into the characteristics of these models. The approach involves characterizing the queueing system's manifold using information geometry and presenting the exponential of the information matrix. This integration of information geometry with queueing theory provides a novel perspective for analyzing the dynamics of queueing systems, incorporating relativistic and Riemannian concepts. Some applications to E-health are highlighted. Finally, closing remarks and the next phase of research.
A Retrospective Study of Wharton’s Jelly Tissue Allografts for Rotator Cuff Defect Applications
Authors: Lai Albert , Tamea Conrad , Shou John , Okaf Anthony , Sparks Jay , Dodd Renee , Woods Crislyn , Lambert Naomi , Schulte Orion Leiloni , Barrett Tyler Chadd
Published: January 2024

With the increasing occurrence of rotator cuff injuries every year, there is a great need for a reliable treatment option. Wharton’s Jelly contains several components that can positively impact the replacement and repair of musculoskeletal defects. The overall objective of this study is to evaluate the improvement of patient-reported pain scales after applying Wharton’s Jelly (WJ) in rotator cuff defects. Eighty-seven patients with rotator cuff defects who failed at least eight weeks of conservative treatment were selected from the retrospective repository. 2cc of WJ flowable allograft was applied to the specific affected anatomy, the most common being supraspinatus tendon, biceps tendon insertion, labral tear, and subscapularis tear. Patients were monitored for 30 minutes post-procedure. No adverse reactions were reported. Statistically significant improvements were found from initial to Day 90 for all pain scales used. No statistically significant differences were found in mean changes between gender, BMI, and age. Scanning Electron Microscopy images reveal the similarities between the collagen matrix in WJ and the rotator cuff. The significant improvement in patient outcomes coincides with current literature analyzing WJ applications with other structural defects around the body. WJ is a promising alternative for musculoskeletal defects when the standard of care fails.
The Role of Wide Excision of Primary Lesion in Cutaneous Malignant Melanoma: A Retrospective Analysis on Its Usefulness in Local and General Control of Disease
Authors: Nacchiero Eleonora , Giotta Massimo , Robusto Fabio , Metta Maria Elvira , Ronghi Valentina , Elia Rossella , Trerotoli Paolo , Giudice Giuseppe
Published: January 2024

Actually wide excision is recommended after the primary excision of any cutaneous melanomas. The definition of the margins of wide excision indicated by the guidelines has remained unchanged over the years, although the reported indications derived from fairly dated studies, in which melanomas tend to be thicker or in advanced stages at diagnosis. These indications may no longer be current; especially in those patients affected by in situ or thin melanoma, exposing patients to a possible overtreatment. A retrospective observational study was conducted in patients who had undergone surgery for melanoma in a single institution. In a univariate model a melanoma-positive wide excision resulted related with a worst progression free survival (PFS); but this association was not confirmed in the multivariable model. Moreover, logistic model were applied to estimate the probability to find a metastasis after wide local excision (WLE) in relation to demographic data of patients and histologic information of the melanoma. Results testified that the Breslow thickness was the only factor associated with the increase of the risk to found metastases in the WLE area. The ROC curve testified that the optimum cut-off value to differentiate patients with respect those without a tumor-positive wide excision, was a Breslow thickness of 2.31mm in women, and 2.4mm in men.
Hybrid Neural Networks for Enhanced Prediction of Remaining Useful Life in Lithium-Ion Batteries
Authors: Rastegarparnah Alireza , Asif Mohammed Eesa , Stolkin Rustam
Published: January 2024

With the proliferation of electric vehicles (EVs) and the consequential increase in EV battery circulation, the need for accurate assessment of battery health and remaining useful life (RUL) is paramount, driven by environmentally friendly and sustainability goals. This study addresses this pressing concern by employing data-driven methods, specifically harnessing deep learning techniques to enhance RUL estimation for lithium-ion batteries (LIB). Leveraging the Toyota Research Institute Dataset, consisting of 124 lithium-ion batteries cycled to failure and encompassing key metrics such as capacity, temperature, resistance, and discharge time, our analysis substantially improves RUL prediction accuracy. Notably, the Convolutional-LSTM-Deep Neural Network (CLDNN) model and the Transformer-LSTM (Temporal-Transformer) model have emerged as standout Remaining Useful Life (RUL) predictors. The CLDNN model, in particular, achieved a remarkable Mean Absolute Error (MAE) of 84.012 and a Mean Absolute Percentage Error (MAPE) of 25.676. Similarly, the Temporal-Transformer model exhibited notable performance with an MAE of 85.134 and a MAPE of 28.7932. These impressive results were achieved through the application of Bayesian hyperparameter optimization, further enhancing the accuracy of predictive methods. These models were benchmarked against existing approaches, demonstrating superior results with an improvement in MAPE ranging from 4.01% to 7.12%.
A New Biocontrol Agent Bacillus velezensis SF334 Against Fungal Leaf Anthracnose of Rubber Tree and Its Genome Analysis for Versatile Plant Probiotic Traits
Authors: Wang Muyuan , Zhang Yikun , Zhao Xinyang , Cai Haibin , Zhu Zhongfeng , Yan Yichao , Yin Ke , Cheng Guanyun , Li Yinsheng , Chen Gongyou , Zou Lifang , Tu Min
Published: January 2024

Natural rubber is an important national strategic and industrial raw material. Leaf anthracnose of rubber tree caused by the Colletotrichum species is one of the important factors restricting the yield of natural rubber. In this study, we isolated and identified strain Bacillus velezensis SF334 that exhibited significant antagonistic activity against both of C. australisinense and C. siamense, the dominant species of Colletotrichum causing leaf anthracnose of rubber trees in Hainan province of China, from a pool of 223 bacterial strains. The cell supernatants of SF334 had a significant prevention effect for leaf anthracnose of rubber tree with an efficacy of 79.67% against C. siamense and 71.8% against C. australisinense, respectively. We demonstrated that SF334 can lead to the lysis of C. australisinense and C. siamense mycelium by causing mycelial expansion, resulting in mycelial rupture and subsequent death. B. velezensis SF334 also harbors some traits of plant growth-promoting rhizobacterium such as secreting siderophore, protease, cellulose, pectinase and auxin of indole-3-acetic acid (IAA), as well as has broad-spectrum antifungal activity against some important plant pathogenic fungi. The genome combined with comparative genomic analyses indicated that SF334 possesses most genes of the central metabolic and secondary metabolites of B. velezensis strains. To our knowledge, this is the first time to report a Bacillus velezensis strain as a promising biocontrol agent against leaf anthracnose of rubber tree caused by C. siamense and C. australisinense. The results suggest that B. velezensis could be a potential candidate agent for leaf anthracnose of rubber tree.
Unlocking the Potential of Chemically Modified Carbon Gels in Gallic Acid Adsorption
Authors: Carvalho Regina Celia , Durán-Valle Carlos Javier , Adame-Pereira Marta
Published: January 2024

This study deals with the preparation of adsorbents from a commercial xerogel by chemically modifying its surface with concentrated mineral acids and alkali metal chlorides, their physicochemical characterization, and their use as adsorbents for gallic acid in aqueous solution. The prepared adsorbents have a high specific surface area (347-563 m2 g-1), better pore development for samples treated with alkali metal chlorides than with mineral acids and are more acidic than the initial xerogel (p.z.c range 2.49-6.87 vs. 7.20). The adsorption properties of the commercial xerogel improved over a wide range of pH and temperature. The experimental results indicate that the adsorption process is thermodynamically favored.
Variability and Error in Measurement of Infant Formula Powder and Water: An Experimental Study
Authors: Rosenkranz* Richard R. , Gonzalez-Alvarez Ana , Acosta Chris , Hooyman Andrew , Hidalgo Jose R. , Ballesteros Paniagua CindyRomina , Rosenkranz Sara K.
Published: January 2024

Formula feeding, as an alternative to breastfeeding, offers benefits such as convenience and consistent nutrition. Among the drawbacks of formula feeding, however, is potential dilution or concentration errors in the of formula during preparation that may lead to infant health issues. The present study aimed to investigate the accuracy of caregiver measurements as they prepared infant formula under multiple conditions, compared with manufacturer specifications. A diverse sample of caregivers (N = 84) participated in this cross-over experimental study. Participants hand-scooped infant formula powder and poured water to prepare 4oz and 7oz feedings, using both a standardized set of infant formula products and participants’ own products. Linear mixed effects models were used to estimate fixed effects of target amount (4oz versus 7oz) and products (participant versus researcher) on mean absolute percent error (MAPE) of measurement. Across all conditions MAPE was significantly greater for measuring powder than for water (9.0% vs. 4.4%; p<0.001) with a combined powder and water MAPE at 13.0%. Greater measurement error was associated with the odd-sized 7oz preparation and participants’ own products. We observed considerable variability and substantial error during infant formula preparation, particularly for hand-scooping of powder, which tended toward higher values than the theoretical gold standard.
Penilaian kualitas dengan walkability index pada jalur pejalan kaki (studi kasus: koridor komersial Jalan Yos Sudarso, Kota Surakarta)
Authors: Hafizh Muhammad Faishal , Yudana Galing , Suminar Lintang
Published: January 2024

Jalur pejalan kaki yang memberikan rasa kenyamanan dan keamanan bagi para pejalan kaki di perkotaan menjadi suatu hal penting yang harus disediakan untuk meningkatkan efektifitas pergerakan masyarakat perkotaan, khususnya pada kawasan komersial. Di sepanjang Jalan Yos Sudarso di Kota Surakarta, penggunaan lahan mayoritas merupakan perdagangan dan jasa berpola linear mengikuti jalan menjadikan terbentuknya koridor komersial. Adanya jalur pejalan kaki seharusnya dapat mengoptimalkan mobilitas para pengunjung yang berkegiatan di koridor tersebut. Namun, dengan beragam permasalahan pada jalur pejalan kaki, kenyamanan dan keamanan para pejalan kaki dapat berkurang. Penelitian ini mengukur kualitas jalur pejalan kaki dengan sembilan variabel yang dimodifikasi dari Global Walkability Index oleh Walkability Survey in Asian Cities. Variabel tersebut adalah (1) konflik jalur pejalan kaki dengan moda transportasi lain, (2) ketersediaan jalur pejalan kaki, (3) ketersediaan penyeberangan, (4) keamanan penyeberangan, (5) perilaku pengendara, (6) amenitas, (7) infrastruktur ramah disabilitas, (8) hambatan, dan (9) keamanan terhadap kejahatan. Data dikumpulkan melalui observasi lapangan secara langsung. Analisis dilakukan dalam tiga segmen berdasarkan karakteristik masing-masing. Temuan walkability index sebesar 30,5 masuk dalam kategori not walkable. Hal tersebut menggambarkan bahwa jalur pejalan kaki di koridor komersial Jalan Yos Sudarso di Kota Surakarta belum sesuai dengan perwujudan konsep urban walkability.
Analisis perbandingan perubahan tutupan lahan menggunakan Citra Satelit Landsat 8 di Kecamatan Tawangmangu
Authors: Anissa Almadea Cherish , Rini Erma Fitria , Soedwiwahjono Soedwiwahjono
Published: January 2024

Kecamatan Tawangmangu merupakan salah satu kecamatan di Kabupaten Karanganyar di dataran tinggi yang menjadi daya tarik wisata. Banyaknya peluang pembangunan infrastruktur penunjang pariwisata membuat wilayah tersebut banyak mengalami perubahan lahan yang signifikan. Informasi mengenai perubahan lahan di Kecamatan Tawangmangu dapat diamati dengan teknologi penginderaan jauh secara time series menggunakan citra satelit. Penelitian ini menggunakan citra satelit Landsat 8 tahun 2013, 2017, dan 2021 untuk diklasifikasikan menjadi data tutupan lahan dengan metode klasifikasi terbimbing. Untuk memperoleh peta tutupan lahan yang akurat maka dilakukan pengolahan dengan tahapan koreksi radiometrik, penajaman citra, klasifikasi terbimbing, dan uji akurasi. Pada metode klasifikasi terbimbing dilakukan pengambilan training area pada lokasi yang mewakili setiap jenis lahan dan dipastikan pada kondisi di lapangan. Hasil dari interpretasi citra berupa peta tutupan lahan Kecamatan Tawangmangu yang kemudian dianalisis dengan metode intersect untuk melihat perubahan tutupan lahan yang terjadi pada periode 2013-2017 dan periode 2017-2021. Penelitian in membandingkan perubahan tutupan lahan yang terjadi di Kecamatan Tawangmangu pada periode 2013-2017 dan periode 2017-2021. Temuan menunjukkan bahwa perubahan tutupan lahan lebih besar terjadi pada periode 2013-2017 seluas 1135,34 ha atau 18,5% dengan luas perubahan setiap jenis tutupan lahan, meliputi area terbangun (200,4 ha), hutan (299,16 ha), lahan pertanian (191,7 ha), kebun (314,48 ha), semak belukar (126,61 ha), dan lahan kosong (2,99 ha).
Tantangan pengelolaan cagar budaya pasca Peraturan Pemerintah Pengganti Undang-undang Nomor 2 Tahun 2022 tentang Cipta Kerja
Authors: Ramadhan Muhammad Fadil , Prasetijo Adi , Fathan Halimy , Afriyanto Deny Setya , Anuraga Jalu Lintang Yogiswara
Published: January 2024

Penerbitan Undang-undang Nomor 11 Tahun 2020 yang teIah diubah menjadi Peraturan Pemerintah Pengganti Undang Undang Nomor 2 Tahun 2022 tentang Cipta Kerja menandakan masuknya babak baru investasi dan pembangunan infrastruktur di Indonesia. Penerbitan aturan ini merupakan runtutan dari upaya pemerintah daIam mempercepat dan memperIuas pembangunan ekonomi Indonesia. Adanya babak baru tersebut menjadi permasaIahan bagi nasib peIestarian Cagar Budaya di Indonesia ke depan, waIaupun daIam haI ini pemerintah baru saja menerbitkan aturan terbaru tentang peIestarian Cagar Budaya, yaitu Peraturan Pemerintah Nomor 1 Tahun 2022 tentang Register NasionaI dan PeIestarian Cagar Budaya. Berdasarkan haI tersebut maka pada kajian ini akan diungkap fenomena yang menunjukkan adanya tantangan pengeIoIaan dan perIindungan cagar budaya daIam menghadapi era baru. Pengungkapan fenomena tersebut diIakukan meIaIui pendekatan yuridis normatif menggunakan data sekunder berupa studi Iiteratur. AnaIisa diIakukan dengan metode anaIisis kesenjangan untuk mengukur tingkat kerawanan cagar budaya. HasiI pada kajian ini menunjukkan bahwa tingkat kerawanan cagar budaya menurut kIasifikasi jenis cagar budayanya adaIah (1) Situs Cagar Budaya dan Struktur Cagar Budaya memiIiki tingkat kerawanan tinggi, (2) Bangunan Cagar Budaya memiIiki tingkat kerawanan menengah, dan (3) Kawasan Cagar Budaya memiIiki tingkat kerawanan rendah. Berdasarkan teIaah tersebut maka perIu diIakukan percepatan penetapan objek dugaan cagar budaya (ODCB) sebagai cagar budaya sebagai Iangkah awaI perIindungan serta mendorong Iahirnya peraturan teknis yang mengatur kajian dampak terhadap warisan budaya sebagai saIah satu prasyarat perizinan berusaha.
Impacto de variables subjetivas en la formación de la confianza del consumidor en México
Authors: Sáenz Canales Itzel Gabriela , González Milán David de Jesús , Ávila Arce Adanelly
Published: January 2024

La teoría económica neoclásica bajo la cual se desarrollan los modelos de consumo presenta algunas deficiencias, este documento propone incluir variables que reflejen aspectos subjetivos del ser humano, explorando los componentes de la confianza del consumidor analizando la Encuesta Nacional de Confianza del Consumidor (ENCO) con la técnica de Análisis de Componentes Principales. Los resultados muestran que las expectativas acerca de las finanzas personales y la percepción de la economía del país representan el componente más importante, esta dimensión de actitudes muestran los planes de compra y pueden ser considerados como predictores del consumo de bienes duraderos.
Congruent Concavity Restoration of the Reconstructed Glenoid After the Latarjet Procedure
Authors: Do Woo-Sung , Shin Seung-Hwan , Lim Joon-Ryul , Yoon Tae-Hwan , Chun Yong-Min
Published: January 2024

Update

This article was updated on April 24, 2024 because of a previous omission, which was discovered after the preliminary version of the article was posted online. Specifically, the following blurb has been added to the first page of the PDF: “A Commentary by Inbo Kim, MD, PhD, is linked to the online version of this article.”

Background:

Few clinical studies have addressed concavity restoration by natural remodeling after a Latarjet procedure. This study investigated the fibrous tissue and osseous remodeling of the reconstructed glenoid and concavity restoration after a Latarjet procedure using postoperative computed tomographic arthrography (CTA).

Methods:

This retrospective study included 31 patients who underwent immediate postoperative computed tomographic (CT) scanning followed by CTA at 6 months postoperatively. We investigated whether fibrous tissue was newly created over the graft, whether the created fibrous tissue restored the congruity of the articular surface and the osseous remodeling of the graft to the glenoid level (whether the osseous portion of the graft was remodeled flush to the glenoid level) and the concavity of the glenoid using the radius of a best-fit circle on the articular surface, and the relationship between the amount of created fibrous tissue and the position of the graft.

Results:

In all patients, the fibrous tissue on the graft yielded a smooth articular surface, as revealed by the CTA. The mean radius of the entire glenoid, including the transferred graft, was significantly smaller (p = 0.010) at 33.2 ± 8.5 mm than that of the glenoid posterior to the osseous step-off at 37.6 ± 9.4 mm, which is presumed to be the glenoid before the surgical procedure. Despite the congruity of the articular surfaces due to fibrous tissue seen in the CTA, 14 (45%) of 31 patients showed a subchondral osseous step-off on either the medial side or the lateral side in the immediate postoperative CT scans. However, through osseous remodeling, 8 of the 10 grafts with a lateral step-off and 2 of the 4 grafts with a medial step-off converted to a flush position. The position of the step-off was correlated with the thickness of the fibrous tissue, with a tendency for thicker tissue in cases of a step-off on the medial side (p = 0.014).

Conclusions:

Fibrous tissue formation plus remodeling of the transferred graft resulted in the restoration of a congruent concavity after a Latarjet procedure by compensating for initially non-flush positioning of the graft. However, due to the small sample size in our study, clinical outcomes could not be correlated with radiographic findings, and our recommendation is to continue placing the graft as anatomically as possible.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Sagittal Alignment in the Degenerative Lumbar Spine
Authors: Diebo Bassel G. , Balmaceno-Criss Mariah , Lafage Renaud , McDonald Christopher L. , Alsoof Daniel , Halayqeh Sereen , DiSilvestro Kevin J. , Kuris Eren O. , Lafage Virginie , Daniels Alan H.
Published: January 2024

➤ Sagittal alignment of the spine has gained attention in the field of spinal deformity surgery for decades. However, emerging data support the importance of restoring segmental lumbar lordosis and lumbar spinal shape according to the pelvic morphology when surgically addressing degenerative lumbar pathologies such as degenerative disc disease and spondylolisthesis.

➤ The distribution of caudal lordosis (L4-S1) and cranial lordosis (L1-L4) as a percentage of global lordosis varies by pelvic incidence (PI), with cephalad lordosis increasing its contribution to total lordosis as PI increases.

➤ Spinal fusion may lead to iatrogenic deformity if performed without attention to lordosis magnitude and location in the lumbar spine.

➤ A solid foundation of knowledge with regard to optimal spinal sagittal alignment is beneficial when performing lumbar spinal surgery, and thoughtful planning and execution of lumbar fusions with a focus on alignment may improve patient outcomes.
Profunda Femoris Pseudoaneurysm and Fatal Hemorrhage 2 Weeks After Modified Girdlestone Resection Arthroplasty
Authors: Pasquinelly Adam , Andrews Kyle
Published: January 2024

Case:

A 62-year-old nonambulatory female patient presented with wound dehiscence and purulent bloody drainage 2 weeks after modified Girdlestone resection arthroplasty for subtrochanteric femur fracture. On developing an enlarging thigh hematoma and hemodynamic instability, the patient was taken to the vascular suite where a profunda femoris artery pseudoaneurysm was identified and ligated by the vascular surgery team. The proximal free edge of the resected femur was determined to be the likely cause of arterial injury. Two days later, the patient was taken by the orthopaedic surgery team for debridement and revision resection arthroplasty, but she ultimately decompensated and died.

Conclusion:

We believe this to be the first reported case of this serious complication of the Girdlestone procedure. We hope this case helps bring awareness to the complication and aids in early detection and prompt treatment of femoral artery complications.
Treatment of an Impending Pathologic Sacral Fracture with a Novel Iliosacral Fusion Construct
Authors: Jacobs Robert C. , Polly David W.
Published: January 2024

Case:

A 49-year-old woman presented with left leg radiculopathy and posterior pelvic pain. Subsequent evaluation demonstrated metastatic multiple myeloma with an impending left S1 sacral fracture. Immediate posterior pelvic ring stabilization was recommended to prevent fracture and disruption of her oncologic recovery. This was performed percutaneously with computer-assisted navigation using a novel cannulated screw design.

Conclusion:

The patient was treated with prophylactic percutaneous posterior pelvic ring fixation with a novel cannulated screw design that provided a durable construct for immediate weight-bearing. The fixation prevented a pathologic fracture and allowed immediate return to activity.