bluuebunny/crossref_metadata_2025 huggingface dataset:
DETERMINAÇÃO DAS TAXAS DE SUJIDADE PARA MÓDULOS FOTOVOLTAICOS DE FILME FINO E SILÍCIO CRISTALINO INSTALADOS EM DIFERENTES ZONAS CLIMÁTICAS BRASILEIRAS
Authors: Silva Costa Suellen Caroline , Alves Cardoso Diniz Antônia Sônia , Camatta Vinícius , Lee Kazmerski Lawrence
Published: July 2023

O acúmulo de sujidades sobre módulos fotovoltaicos (FV) induz na redução do desempenho destes dispositivos, podendo ser ainda mais agravante em regiões consideradas atrativas para a aplicação dessa tecnologia, onde a irradiância apresenta elevados índices ao longo do ano, porém sob predominância de clima seco e árido propício para a deposição de sujidades. Os efeitos do acúmulo de sujeira no desempenho dos módulos FV são específicos para cada localidade, uma vez que o comportamento da deposição e a composição físico-química dos contaminantes são influenciados por um conjunto de variáveis específicas do local de instalação dos módulos fotovoltaicos. Neste cenário, este artigo apresenta uma metodologia para quantificar a taxa de sujidade (“Soiling Ratio” – SRatio) e a relação de sujidade diária (“Soiling Rate” – SRate) em módulos FV de telureto de cádmio (CdTe) e silício policristalino (p-Si) através de medições realizadas em estações de monitoramento instaladas em diferentes zonas climáticas do Brasil. Os resultados obtidos neste trabalho indicaram: (1) Belo Horizonte/MG (latitude - 19,92°, longitude -43,99°), um SRatio médio para o período de análise de 0,94 para telureto de cádmio (CdTe) e 0,92 para silício policristalino (p-Si); (2) Porto Alegre/RS, (Latitude -30,05 °, Longitude -51,17 °), um SRatio em torno de 0,97 e 0,98 para as tecnologias CdTe e p-Si, respectivamente; e (3) Brotas de Macaúbas/BA (Latitude -11,99°, Longitude -42,62°), SRatio de 0,99 e 0,95 para as tecnologias CdTe e p-Si, respectivamente. A partir das características do SRatio, os dados do período seco foram utilizados para estimar o SRate através do estimador Theil-Sen, resultando em valores médios de -0,20%/dia para o CdTe e -0,14%/dia para Belo Horizonte/MG. O maior SRate para tecnologia CdTe pode ser justificado devido a diferença nas respostas espectrais das duas tecnologias FV, pois a sujeira tem um impacto maior nas tecnologias fotovoltaicas de menor comprimento de onda.
ESTUDO DE CASO DE UM SISTEMA FOTOVOLTAICO INSTALADO NO CAMPUS DA UNICAMP EM DIFERENTES SOFTWARES DE SIMULAÇÃO
Authors: Vieira Machado Gilson Mário , De Souza Silva João Lucas , Soeiro Moreira Hugo , Do Nascimento Vargas Tiane , Cerbatto Schmitt Prym Guilherme , Pinheiro Lima Geyciane , Gradella Villalva Marcelo
Published: July 2023

A energia solar fotovoltaica (FV) tem se destacado com um crescimento exponencial na matriz energética brasileira, e devido a isso vem recebendo grandes investimentos em pesquisa.  Na Universidade Estadual de Campinas, o Projeto Campus Sustentável efetuou a instalação de 11 plantas FV, distribuídas em diferentes edificações da universidade, com o objetivo de realizar pesquisas na região de Campinas - Brasil. Dessa forma, este artigo apresenta o resultado de simulações da planta FV de uma das instalações FV, a Escola de Extensão da Unicamp (Extecamp), que possui potência instalada de 22,95 kWp. A simulação foi realizada em diferentes softwares visando obter dados para análises futuras e verificar se a instalação FV funciona como projetado. Para isso, foram utilizados os softwares HelioScope, PV*SOL e PVsyst para as simulações, e em seguida comparados os resultados com os meses contendo os valores de geração real da planta FV. Como resultado, as três simulações apresentaram desempenho satisfatório, com geração próxima aos valores de monitoramento da planta real. Portanto, a planta FV está funcionando conforme projetada, e as principais características dos três softwares foram apresentadas como contribuição do artigo.
ESTUDO DA COBERTURA DE NUVENS NO SERTÃO CENTRAL DO CEARÁ, MEDIDO PELO SATÉLITE SCD2 DO INPE
Authors: Veissid Nelson
Published: July 2023

O segundo satélite da Missão Espacial Completa Brasileira do Instituto Nacional de Pesquisas Espaciais foi colocado em órbita em 23 de outubro de 1998 e leva a bordo um experimento de células solares produzidas no Brasil. O principal objetivo deste experimento é o de qualificar as células em missão. Ele atua como um sensor de radiação e pode medir a radiação solar direta e a parte desta radiação que é refletida pelo planeta Terra. Portanto, como um subproduto, o experimento mede o albedo planetário e estatística realizada nos dados de albedo permite estudar padrões e tendências para diferentes áreas sobre a América do Sul. O sertão central do Ceará foi escolhido para este estudo porque é uma área de interesse para o Congresso. A região é um quadrado de 2° de lados em latitude e longitude centrado em 5° Sul e 39,5° Oeste. Nesta área, as curvas de tendências anuais e trimestrais e seus respectivos desvios padrão (variabilidade) mostram que os valores do albedo planetário estão com tendência em diminuir e, este fato, é mais intenso no trimestre referente aos meses de Dezembro, Janeiro e Fevereiro. O trabalho, também, mostra o estudo da fração da cobertura de nuvens usando dados do albedo planetário, o qual apresenta diminuição em valor absoluto de 0,20% por ano.
MODELAGEM ESPECTRAL E AVALIAÇÃO DOS IMPACTOS ESPECTRAIS NO DESEMPENHO DAS TECNOLOGIAS FOTOVOLTAICAS DE MC-SI E CDTE EM CLIMAS QUENTES E ENSOLARADOS
Authors: Braga Marília , Rafael do Nascimento Lucas , Rüther Ricardo
Published: July 2023

Este artigo apresenta uma análise dos impactos espectrais nas tecnologias mc-Si e CdTe em duas regiões distintas do Brasil: Florianópolis-SC (27 ° S, 48 ° W) no Sul e Assu-RN (5 ° S, 37 ° W) no Nordeste. À medida que usinas fotovoltaicas de grande porte estão sendo implantadas progressivamente no nordeste brasileiro, surge a necessidade de avaliação dos efeitos dos espectros locais no desempenho de diferentes tecnologias fotovoltaicas. Considerando o alto custo de equipamentos de medição espectral adequados, este artigo propõe uma nova abordagem para a estimativa de impactos espectrais sem a necessidade de medições in loco. A metodologia proposta consiste no uso de dados de satélite adquiridos da plataforma Giovanni da NASA como entradas para o modelo de espectro SMARTS 2.9.5. Os resultados dos espectros medidos mostraram que, para os dois locais, a tecnologia de CdTe apresenta ganhos espectrais significativos: até 10% para Assu-RN (Nordeste) e 2% para Florianópolis-SC (Sul). Uma variação sazonal também pode ser observada para ambos os locais, com ganhos espectrais mais baixos para CdTe - e mais altos para mc-Si - próximos ao solstício de inverno do Hemisfério Sul, devido a valores mais elevados de massa de ar e menor teor de água precipitável na atmosfera. O método proposto usando dados de Giovanni e modelagem de espectros SMARTS produziu espectros muito semelhantes aos medidos para dias de céu limpo em ambos os locais, produzindo bons resultados para o cálculo de fatores espectrais para ambas as tecnologias avaliadas. Nos dias com maior fração difusa, os resultados não foram tão satisfatórios, de acordo com já era esperado.
ANÁLISE DE VIABILIDADE TÉCNICA, ECONÔMICA E AMBIENTAL DA IMPLANTAÇÃO DE SISTEMAS FOTOVOLTAICOS EM PRÉDIOS PÚBLICOS DE SOBRAL-CE
Authors: Galvão de Mesquita Furtado Cleiton , De Oliveira Marcelo Júnior Audelis , Filho de Brito Ramos Teomar , Pontes de Deus Enio
Published: July 2023

Embora se trate de uma fonte promissora que tem crescido no mundo inteiro, o uso da tecnologia fotovoltaica no abastecimento energético de prédios públicos brasileiros ainda está muito aquém do potencial de geração existente no país. Assim, o objetivo geral deste trabalho é analisar a viabilidade técnica, econômica e ambiental da implantação de sistemas de energia solar fotovoltaica para abastecimento do consumo energético de prédios públicos de Sobral, no Ceará. Para isso, foi realizada uma revisão bibliográfica sobre o funcionamento e dimensionamento de sistemas fotovoltaicos; em seguida, a partir dos dados referentes ao consumo mensal médio dos prédios, foram simulados quatro sistemas fotovoltaicos com distintas faixas de potência. Por meio de pesquisa de mercado, foram estimados os preços médios dos componentes dos sistemas, gerando orçamentos preliminares para cada sistema proposto. Foi possível constatar que a implantação dessa tecnologia é vantajosa, proporcionando grandes economias mensais à administração municipal. Os sistemas do Grupo B apresentaram payback de aproximadamente 4 anos e Taxa Interna de Retorno (TIR) média de 28%. Já os sistemas do Grupo A, apresentaram payback de 7 anos e TIR média de 14%. Ademais, enquanto os sistemas do Grupo A só conseguirão abater cerca de 50% do valor da fatura energética em reais, os sistemas do Grupo B conseguirão abater mais de 95%. Com isso, conclui-se que, de modo geral, o investimento em sistemas do Grupo B é mais vantajoso que em sistemas do Grupo A. Além da redução de custos, o uso da energia solar fotovoltaica em prédios públicos de Sobral permitirá uma considerável diminuição das emissões de dióxido de carbono, podendo tornar a iniciativa uma referência para os demais municípios do Brasil.
SỬ DỤNG THÍ NGHIỆM TRONG DẠY HỌC NỘI DUNG CẢM ỨNG, SINH TRƯỞNG VÀ PHÁT TRIỂN - SINH HỌC 11 NHẰM PHÁT TRIỂN NĂNG LỰC THỰC NGHIỆM CHO HỌC SINH
Authors: Đỗ Thành Trung
Published: July 2023

Sinh học là một môn khoa học thực nghiệm, việc sử dụng thí nghiệm trong dạy học Sinh học là một phương pháp tích cực nhằm phát triển năng lực thực nghiệm, rèn luyện kĩ năng làm thí nghiệm và phát triển tư duy khoa học, tư duy nghiên cứu khoa học đồng thời hình thành được kiến thức Sinh học. Nghiên cứu này có mục tiêu tập trung đưa ra các nguyên tắc sưu tầm, lựa chọn và quy trình sử dụng thí nghiệm trong dạy học các nội dung Cảm ứng, sinh trưởng và phát triển – Sinh học 11. Kết quả nghiên cứu làm cơ sở cho việc nâng cao năng lực thực nghiệm  cho học sinh.
Comparative study of the cardiovascular system of the long-livers in the population of Lankaran Region
Authors: Hüseynova S.İ.
Published: July 2023

Tədqiqatda Azərbaycan Respublikasının Lənkəran rayonunda yaşayan uzunömürlülər müayinə olunmuşdur. Alınmış nəticələr göstərdi ki, uzunömürlülərdə güclü adaptiv kompensator və genetik faktorlar hesabına patolji və invalyusion dəyişikliklər letal sonluğa gətirib çıxarmır. Bu özünü həm arterial təzyiqin (AT), həm də ürək döyüntülərinin sayının (ÜDS) tənzimlənməsində göstərir. Yaşla əlaqədar kardiovaskulyar dəyişikliklər tədrici fizioloji qocalmanın əsas göstəricisi və ürək damar sisteminin funksional ehtiyatlarının və adaptasiya imkanlarının qorunub saxlanmasının göstəricisidir ki, bu da tədqiq olunan üzünömürlülərin 30 %-də qeydə alınırdı. Uzunömürlülərin yaxın qohumlarında irsi faktor özünü daha qabarıq göstərir, belə ki, eyni ekoloji şəraitdə yaşamaqlarına baxmayaraq kontrol qrupa nisbətən daha güclü adaptasiya imkanlarına malikdirlər.

The studies were carried out on long-lived people living in the Lankaran region of the Republic of Azerbaijan. The results of the monitoring showed that pathological and involutional changes caused by strong adaptive-compensatory and genetic factors in long-lived people didn't lead to death. This was reflected in the regulation of both blood pressure and heart rate. Cardiovascular changes associated with aging are the main indicator of gradual physiological aging and preservation of the functional resources and adaptive capacities of the cardiovascular system, which are recorded in 30% of long-lived people. Close relatives of long-livers have a hereditary factor that is brighter since they have the same relative adaptive capacity compared to the control group, despite the fact that they live in the same ecologically clean environment.
Study results on the molecular genetic, morphometric and sexual characteristics of the beluga (Huso huso L., 1758) grown in the aquaculture of the Republic of Belarus
Authors: Slukvin A.M. , Dromashko S.Y. , Balashenko N.A. , Barulin N.V. , Barmintseva A.Y.
Published: July 2023

The subject of the study was the genetic and phenotypic characteristics of Beluga (Huso huso (Linnaeus, 1758)) grown in the warm-water aquaculture at the “Selets” fish farm (the Republic of Belarus). Molecular-genetic analysis was performed using STR-markers and species-specific PCR revealed the absence of hybrid individuals in the analyzed broodstock of (Huso huso L.). Affiliation of individuals to the Caspian population was established based on the sequence analysis of the 367 bp region of the mitochondrial D-loop. Using six STR loci, the population structure was analyzed. The population structure and gene pool of the only broodstock of (Huso huso L.) in Belarus were compared with domesticated (H. huso L.) from the Russian Federation. The analysis showed a lack of genetic variation and the heterozygote excess in Beluga from the Belarusian farm. Analysis of morphometric indicators revealed that the conditions in which the Beluga broodstock is kept at the fish farm “Selets” should be improved. Using ultrasound scanning, the following stages of gonad maturity were established: stages II, III, and IV in males; II, II semi-fatty, II fatty, and II-III in females. The beluga broodstock at the fish farm “Selets” is mainly represented by females (the females exceeded the males by 2.3 times in terms of their number).
Effect of hypoxic preconditioning on lactate dehydrogenase activity in the brain of albino rats exposed to prenatal hypoxia
Authors: Rəşidova A.M.
Published: July 2023

Laktatdehidrogenaza fermentinin (LDH; L-lactate: NAD oxidoreductase, EK 1.1.1.27) fəallığının dinamikası prenatal inkişafda əvvəlcədən hipoksik prekondisionlaşmış, sonra isə kəskin 5%-li hipoksiyaya məruz qalmış ağ siçovulların baş beyin nahiyələrində postnatal ontogenezdə müqayisəli şəkildə təyin dilmişdir. Alınan nəticələr göstərir ki, hipoksiyanın təsirinə cavab olaraq postnatal dövrün müddəti uzandıqca fermentin fəallığının kontrol göstəricilərinə uyğun bərpası baş vermir. Statistik hesablamalara görə, fermentin fəallığı yalnız 5%-li hipoksiyanın təsirindən sonra alınan göstəricilərdən bir neçə dəfə aşağı, kontrol ilə müqayisədə isə nisbətən yüksək olmuşdur. Fərz etmək olar ki, hipoksik prekondisionlaşma üsulunun tətbiqi kəskin hipoksiyanın mənfi təsirinə qarşı beynin enerji mübadiləsində müəyyən protektor rolunu reallaşdıra bilmişdir.

Lactate dehydrogenase activity was determined in a comparative aspect at 17, 30, and 90 days of postnatal development in the brain structures of white rats that were prenatally exposed to preconditioned hypoxia, then to 5% hypoxia. As the date show with the prolongation of postnatal development period, the restoration of the enzyme activity to the control level did not take place in response to hypoxia. According to the date obtained, the enzyme activity turned out to be several times lower than after exposure to hypoxia of only 5% and higher than in control values. One can assume that application of preconditioned hypoxia played the role of a protector in the energy metabolism of the brain in hypoxia.
The effects of heavy metals on the developing brain
Authors: Inozemtsev A.N. , Hashimova U.F. , Ismayilova Kh.Y. , Karpukhina O.V. , Inozemtsev Fermin Y.A. , Rustamov F.E. , Ibrahimov R.I.
Published: July 2023

The analysis shows that there are disproportionately few works on the mentioned joint effects of HMs in relation to the importance of this issue. It was found that the joint administration of HMs with each other and under stress increases the neurotoxic effect of metals on the brain of animals. A greater vulnerability to the neurotoxic effects of HM mixtures on the developing brain was also noted. Neurotropic drugs in combination with HMs have multidirectional effects. Thus, along with the counteraction of the reference nootropic piracetam to the inhibition of the avoidance response in rats, which is exerted by HMs, there was an increase in the neurotoxic effects of lead and cadmium salts when combined with that nootropic. Combined administration of Semax (a regulatory peptide with nootropic effects) and molybdenum, which separately suppressed the avoidance response in rats, paradoxically improved learning and memory. The revealed unpredictability and enhancement of the neurotoxic effects of HMs when combined with neurotropic agents are fraught with danger to human health in regions with developed industries. This is especially important for the health of children due to the increased vulnerability of their developing brains to neurotoxicants.
The activity of enzymes of glutamate metabolism in the brain following exposure to prenatal hypoxia of varying severity
Authors: Хаирова В.Р. , Гадирова Л.Б.
Published: July 2023

В работе исследовалось влияние пренатальной гипоксии различной степени тяжести на активность ключевых ферментов глутаматного обмена – глутаминазы и глутаминсинтетазы в различных областях мозга крыс. Была выявлена обратная корреляция в активности ферментов глутамат-глутаминового цикла в большом мозге потомства крыс, переживших влияние различных режимов гипоксического воздействия в период органогенеза пренатального развития. На фоне снижения активности глутаминсинтетазы отмечается повышение активности глутаминазы в структурах большого мозга 17-дневных крысят. Причем, характер изменения ферментативной активности зависит от степени тяжести гипоксического воздействия. Следовательно, пренатальная гипоксия приводит к нарушению метаболизма глутамата в большом мозге и создает условия для его накопления в нервных клетках. Данные нарушения, возможно, обусловлены изменениями механизмов обратного захвата и утилизации глутамата или повреждением структуры ферментов, и приводят в итоге к нарушениям глутаматергической передачи.

The effect of prenatal hypoxia of varying severity on the activity of glutaminase and glutamine synthetase in various rat brain regions was studied in this work. The study revealed an inverse correlation in the activity of enzymes of the glutamate-glutamine cycle in the brain of rat offspring that survived the influence of hypoxic exposure in various severity during the period of organogenesis of prenatal development. Against the background of a decrease in glutamine synthetase activity, an increase in glutaminase activity in the brain structures of 17-day-old rat pups was noted. Moreover, the nature of the change in enzymatic activity depended on the severity of the hypoxic influence. Consequently, prenatal hypoxia led to disruption of the metabolism of glutamate in the brain and created conditions for its accumulation in nerve cells. These disorders are possibly caused by changes in the mechanisms of reuptake and utilization of glutamate or damage enzyme’s structure and ultimately led to disturbances in glutamatergic transmission.
PENINGKATAN KEMAMPUAN MEMBACA MELALUI PENDEKATAN WHOLE LANGUAGE PADA SISWA KELAS 1 SDN TANJUNG JATI 2
Authors: Agustin Cindy Erra , Setyawan Agung
Published: July 2023

Penelitian ini bertujuan untuk meningkatkan kemampuan membaca siswa kelas 1 dengan menggunakan pendekatan Whole language di SDN Tanjung Jati 2, Kecamatan Kamal, Kabupaten Bangkalan. Penelitian ini menggunakan metode penelitian Tindakan Kelas dengan melibatkan observasi langsung terhadap peserta didik dan penggunaan tes sebagai alat pengumpulan data. Penelitian ini dilakukan dalam dua siklus, yaitu siklus satu dan siklus dua. Hasil penelitian menunjukkan adanya peningkatan yang signifikan dalam kemampuan membaca siswa kelas 1 di SDN Tanjung Jati 2, Kecamatan Kamal, Kabupaten Bangkalan. Pada siklus satu, persentase siswa yang mencapai Ketuntasan Minimal (KKM) dalam kemampuan membaca adalah sebesar 30%. Namun, pada siklus dua, persentase siswa yang mencapai KKM meningkat menjadi 78%. Berdasarkan hasil penelitian ini, dapat disimpulkan bahwa penggunaan pendekatan Whole language dalam pembelajaran mata pelajaran Bahasa Indonesia dapat efektif meningkatkan kemampuan membaca peserta didik. Oleh karena itu, disarankan agar pendekatan Whole language terus diterapkan dalam proses pembelajaran di SDN Tanjung Jati 2 maupun sekolah-sekolah lainnya guna meningkatkan keterampilan membaca siswa.
Perancangan Board Game “FuitVege Missions” dengan Mekanik Pattern Movement sebagai Media Edukasi Pencegahan Malnutrisi Untuk Usia 10-11 Tahun
Authors: Anggriani Grace , Prasida T. Arie Setiawan , Prestiliano Jasson
Published: July 2023

Sayur dan buah diperlukan tubuh sebagai sumber gizi seperti vitamin, mineral dan serat dalam mencapai pola makan sehat sesuai anjuran pedoman gizi seimbang untuk kesehatan yang optimal. Pengetahuan tentang nilai gizi dapat mempengaruhi konsumsi buah dan sayur seseorang. Selain itu, terdapat penelitian yang menyebutkan bahwa terjadi peningkatan konsumsi buah dan sayur pada responden setelah mendapatkan intervensi mengenai manfaat konsumsi sumber zat gizi serat pada siswa. Media yang tepat digunakan sebagai intervensi gizi berupa edukasi gizi dan promosi makan sehat. Dengan adanya media yang menarik, dapat meningkatkan konsumsi sayur dan buah pada anak, setelah anak mengerti manfaatnya. Board game dinilai sebagai media interaktif yang dapat masuk ke dalam dunia anak-anak, dengan bermain board game juga dapat melatih aspek psikomotorik, kognitif, emosional, moral, seni dan juga bahasa.
COVID-19 proactive screening protocol during early outbreak using web-based application: Implementation in Thai Rural Area
Authors: Kloypan Chiraphat , Khamduang Woottichai , Prompunt Eakkapote , Saoin Somphot , Jourdain Gonzague , Ngo-Giang-Huong Nicole , Nangola Sawitree
Published: July 2023

Coronavirus disease 2019 (COVID-19) caused by an infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been recognized as one of the biggest problems to human health worldwide. The potential strategy to control the spreading of the virus is awareness of infection status, especially among non-patient under investigation (non-PUI). Additionally, implementing gathering control and suspending “social distancing” are key to a decrease in the chance of infection. This study aimed to conduct and implement the pilot management system for COVID-19 testing and to perform proactive screening test among non-PUI people in Phayao Province, the rural area of Thailand. This was a cross-sectional study. People who could access websites- or mobile applications were eligible to be recruited into the study. An online questionnaire was developed to collect information on socio-demographics, medical conditions and symptoms related to COVID-19 from participants who were living in Phayao Province from July to August 2020. 200 participants performed self-evaluation but only 143 (71.5%) participants booked an appointment and visited the collecting site to get the test. There were 25 (9%) participants being at high risk of infection. The nasopharyngeal/throat swabs were collected and proceeded to determine a presence of SARS-CoV-2 using RT-PCR. Of all, none was found to be positive for SARS-CoV-2. In conclusion, this developed management system would be an important tool for managing laboratory testing during the COVID-19 outbreak by means of reducing the chance of infection in the epidemic situation. This proactive screening system can also be applied for other medical testing and services.
ผลของสารสกัดบอระเพ็ดต่อการลดไข้ ปริมาณเกล็ดเลือด และชีวเคมีของเลือดในหนูวิสตาร์
Authors: ศุภกิจเจริญกุล พงษ์พิทักษ์ , ยะมา ศราวุธ , โพธิชัย กรวีร์ , อรุโณรัตน์ จิรภัทธ , ยี่หวา รัญชนา , ศิริลุน ศศิธร , ยศวิมลวัฒน์ ทรงวุฒิ , ศิริสะอาด พาณี , จารุมณี สุพร
Published: July 2023

บอระเพ็ด (Boraphet: Tinospora crispa (L.) Miers ex Hook. f. & Thomson) เป็นพืชที่พบในแถบเอเชียกลาง และเอเชียตะวันออกเฉียงใต้ แพทย์แผนโบราณในหลายประเทศ รวมทั้งประเทศไทย มีการนำส่วนของเถา รากและใบ ใช้ในการบำบัดรักษาโรคหลายอย่าง เช่น ต้านการอักเสบ ลดไข้ ลดระดับน้ำตาลในเลือด กระตุ้นภูมิคุ้มกัน ต้านมาลาเรีย ต้านแบคทีเรีย ต้านมะเร็ง และเจริญอาหาร เป็นต้น การวิจัยนี้มีวัตถุประสงค์เพื่อศึกษาการลดไข้ของสารสกัดบอระเพ็ดด้วยเอทานอลและน้ำ ผลต่อปริมาณเกล็ดเลือดและค่าชีวเคมีของเลือดในหนูวิสตาร์  โดยเก็บตัวอย่างเลือดก่อนการทดลอง 72 ชั่วโมง ในการทดสอบฤทธิ์ลดไข้ หนูทดลองถูกกระตุ้นให้เกิดไข้ด้วยวัคซีนคอตีบ บาดทะยัก และไอกรน (Diphtheria-tetanus-pertussis: DTP) เมื่อเกิดไข้หนูจะได้รับสารสกัดปริมาณเทียบเท่ากับผงบอระเพ็ด 30, 90 และ 270 มก. ต่อน้ำหนักตัว 1 กก. โดยให้ทางปาก จากนั้นวัดไข้ทางทวารหนักทุก 30 นาที จนครบ 240 นาที แล้วเก็บตัวอย่างเลือดอีกครั้งหลังจากครบเวลา ผลการศึกษาวิจัยนี้ พบว่าสารสกัดบอระเพ็ดด้วยเอทานอล ขนาด 30, 90, 270 มก. ต่อน้ำหนักตัว 1 กก. มีค่าเฉลี่ยในการลดไข้เท่ากับ 1.62±0.33, 1.68±0.51 และ 1.48±0.32°C ตามลำดับ ในขณะที่สารสกัดบอระเพ็ดด้วยน้ำ ทั้งสามความเข้มข้น มีค่าเฉลี่ยในการลดไข้เท่ากับ 1.18±0.19, 1.14±0.31 และ 1.32±0.36°C ตามลำดับ ทั้งนี้ กลุ่มควบคุมบวก ที่ได้รับพาราเซตามอลและไอบูโปรเฟน มีค่าเฉลี่ยในการลดไข้ เท่ากับ 1.62±0.78 และ 1.48±0.18°C ตามลำดับ และกลุ่มควบคุมลบมีค่าเฉลี่ยในการลดไข้ 0.96±0.31°C นอกจากนี้ พบว่ากลุ่มหนูวิสตาร์ที่ได้รับสารสกัดบอระเพ็ดมีปริมาณเกล็ดเลือดก่อนและหลังการทดลองไม่แตกต่างจากกลุ่มควบคุม และผลวิเคราะห์ชีวเคมีของเลือดไม่แตกต่างจากกลุ่มควบคุมอย่างมีนัยสำคัญ โดยพบว่าหนูวิสตาร์ที่ได้รับสารสกัดบอระเพ็ดด้วยน้ำขนาด 270 มก. ต่อน้ำหนักตัว 1 กก. มีค่าเอนไซม์ AST เพิ่มขึ้นเล็กน้อย และค่าเอนไซม์ ALT หลังได้รับสารสกัดมีค่าเพิ่มขึ้นแต่ไม่แตกต่างกับกลุ่มควบคุม อย่างมีนัยสำคัญ สามารถสรุปได้ว่าสารสกัดบอระเพ็ดด้วยเอทานอลมีประสิทธิผลในการลดไข้ได้ดีกว่าสารสกัดด้วยน้ำ และไม่แตกต่างกับกลุ่มควบคุมบวกอย่างมีนัยสำคัญ ในขณะที่ปริมาณเกล็ดเลือดและค่าชีวเคมีของเลือดในกลุ่มทดลองไม่แตกต่างจากกลุ่มควบคุมอย่างมีนัยสำคัญ (p>0.05)
Hubungan Persepsi Dukungan Organisasi Terhadap Kinerja Aparatur Sipil Negara Kantor Kementerian Agama Kabupaten Kerinci
Authors: Budaya Indra , Herlina Vivi
Published: July 2023

Penelitian ini bertujuan untuk melihat hubungan Dukungan Organisasi dengan Kinerja Aparatur Sipil Negara Pada Kantor Kementerian Agama Kabupaten Kerinci. Metode penelitian yang di gunakan dalam penelitian ini adalah Metode Kuantitatif, karena peneliti menginginkan pengukuran antara Variabele X dan Y. Sampel dalam penelitian ini 35 orang. Teknik yang di gunakan dalam penentuan responden adalah sampling jenuh sedangakan  instrument penelitian berupa kuisioner. Teknik analisis penggunaan uji hipotesis, dengan hasil penelitian dapat dilihat 3.1285 > 2.0345sehingga Ha diterima dan Ho ditolak. Artinya bahwa dukungan orgainsasi mempunyai hubungan yang signifikan dengan Kinerja Aparatur Sipil Negara Pada Kantor Kementerian Agama Kabupaten Kerinci.
Comment des PME peuvent-elles être résilientes en contexte de crises multiples ? Étude de cas longitudinale d’une PME libanaise engagée en RSE
Authors: Dubruc Nadine , Khawaja Danie
Published: July 2023

Cet article propose une recherche sur la résilience des PME face à des crises multiples dans un contexte très particulier, celui du Liban. Ce pays traverse depuis 2019 de multiples crises qui ont eu différentes conséquences sur l’emploi et la vie des entreprises. Une recherche exploratoire à partir d’une étude de cas longitudinale d’une PME libanaise montre comment celle-ci a pu être proactive dans la gestion des différentes crises vécues dans son pays. Diriger une entreprise résiliente face à de multiples crises consiste pour un dirigeant à garder le cap sur des projets à long terme tout en adoptant des actions pour contrer les effets de chacune d’elles. Ainsi, cette entreprise engagée en RSE parvient à surmonter les crises en adoptant des actions avec un impact social, environnemental et économique. La gouvernance multi-parties prenantes basée sur l’écoute des parties prenantes, inscrite dans le court terme et le long terme, induit une GRH durable permettant une meilleure résilience organisationnelle face à de multiples crises.
L’approche environnementale dans la compréhension et l’accompagnement des agriculteurs et des agricultrices en difficulté
Authors: Terrier Eugénie
Published: July 2023

La réflexion présentée dans cet article s’appuie sur une recherche au sujet d’une expérimentation partenariale et locale d’aide à la reconversion professionnelle d’exploitant.es agricoles en difficulté dans un département de l’Ouest de la France. À partir d’une enquête qualitative par observations et par entretiens auprès d’une diversité d’acteurs (agriculteurs et agricultrices, élu.es, cadres, intervenant.es), il s’agit dans cette recherche d’analyser les situations sociales de ces agriculteurs et agricultrices à partir d’une approche écosystémique et d’interroger les représentations et les pratiques des différents acteurs impliqués dans leur accompagnement. Les résultats montrent que les situations de vulnérabilité des exploitant.es agricoles se situent à l’intersection des influences d’un ensemble d’environnements socio-culturels et spatiaux et des trajectoires individuelles jalonnées d’évènements biographiques plus ou moins fragilisants selon les contextes. Face à ces situations, et même si les acteurs ont conscience de l’influence des environnements, les contraintes institutionnelles et les normes sociales à l’oeuvre restent centrées sur l’activation et la responsabilisation des personnes.
“The Loved Home” and Other Exclusionary Care Discourses
Authors: Liinason Mia
Published: July 2023

Based on a conceptualization of heteroactivism as a transnational phenomenon manifesting in local contexts to spread and express resistance to gender and sexual rights, this article aims to illuminate new dimensions of heteroactivism beyond a sole focus on gender and sexuality by bringing its specificities in the Swedish context to the fore. Drawing on digital ethnography with members of the neo-conservative, far-right thinktank Oikos and the ethnonationalist political party the Sweden Democrats (SD), the article shows how heteroactivist forms of resistance seek to reshape the state and the nation through the gender–sexuality nexus and how these resistances enter into negotiation with spatiohistorically established notions of gender equality and sexual rights. Through a multiscalar transnational approach, the article brings forth how heteroactivism connects several levels horizontally—from the local to the national and the transnational—and vertically and establishes linkages among gender, sexuality, the state and the nation. The analysis reveals how care, love and gratitude for the shared home are core elements used in heteroactivist negotiations, with contextually established notions of gender equality and sexual rights as national values. It also demonstrates how the home, which these actors seek to cherish and protect, takes shape as an exclusive and exclusionary space.
Fertile Ground
Authors: Rasmussen Claire
Published: July 2023

Fears of immigration and demographic change have fueled nativist, pro-natalist movements that support the reproductive, heteronormative family as a vital political project shaping their rhetoric and politics. This paper argues that right-wing populist movements can be situated within heteroactivsm, as reactionary movements positioning themselves against challenges to the heteronormative family. I suggest that understanding the populist character of these movements can help theorize why so many right-wing populists echo specific claims about gender and race. By situating their political claims in biological claims about sex, gender and race, these movements contrast themselves with abstract ideals of universal human rights, neoliberal rationality, and cosmopolitan globalism, embracing the traditional family, gender norms, and heterosexual reproduction. They encourage normative family promoted through state policy of rewarding proper families and punishing improper social reproduction—whether literal reproduction or the cultural reproduction of values. Tracing the broad outlines of a political project anchored in the reproductive bodies of women, I argue for greater attention to the ways the heteroactivist project is central to right-wing populism and its multi-scalar manifestations.
Monedas sociales y economía circular. Sinergias, retos y oportunidades para España
Authors: Tezanos Vázquez Sergio , Ávila Sánchez Manuel
Published: July 2023

Vivimos en un planeta con recursos finitos y con una capacidad también finita de asimilación de residuos. De ahí el reto ineludible que afronta España -y el resto de países- de hacer más circular y sostenible su economía. Este es el camino que nos marcan la Agenda 2030 para el desarrollo sostenible y El Pacto Verde Europeo. Y así se recoge en la estrategia España circular 2030. Pero, dada la colosal dimensión de esta transición ecológica, es imprescindible que las Administraciones Públicas sumen aliados hasta ahora inexplorados, como son las “monedas sociales”. Dichas monedas son experiencias económicas alternativas que pretenden dinamizar la economía local y que pueden ayudar eficazmente a reducir la huella ecológica de sus usuarios.En esta investigación constatamos que existen sinergias entre las monedas sociales y la economía circular, pero que dichas sinergias han sido desconsideradas en la estrategia España Circular 2030. La principal causa de esta desconsideración es que la Administración central desconoce las monedas sociales, lo que se ve agravado por el hecho de que en España estas monedas tienen poco arraigo, son muy heterogéneas, están insuficientemente coordinadas y no suelen contar con la confianza de las administraciones locales.
Middle Ordovician trilobites from the Castillejo Formation, Eastern Iberian Range (NE Spain): taxonomic reappraisal, biostratigraphy, and correlation
Authors: Romero Sara , Gutiérrez-Marco Juan Carlos
Published: July 2023

Middle Ordovician trilobites found in 11 fossil localities from the areas of Alpartir, Aladrén, Luesma and Fombuena (Zaragoza province), and south of Calamocha (Teruel province) are studied. Most records come from the Alpartir Member of the Castillejo Formation, which is dated as Dobrotivian in age (late Darriwilian according to the global scale), with the only exception of two localities that are slightly older, from late Oretanian age (mid−late Darriwilian). In the overlying Sierra Member, three additional localities are recorded, which have estimated age ranges from late early to late Dobrotivian (latest Darriwilian, possibly reaching the Sandbian). A total of 21 different trilobite species were identified including Uralichas hispanicus, Parabarrandia crassa and “Panderia” beaumonti that are recorded for the first time in the Eastern Iberian Range. The main trilobite assemblage from the Alpartir Member belongs to the Placoparia tournemini Biozone, which correlates with numerous areas of southwestern Europe, and here occurs in a biofacies dominated by asaphids. The scarce data derived from the Sierra Member do not allow to distinguish biozones, although the incipient development of a trilobite biofacies adapted to sandy bottoms is recognized, which ends at the top of the Placoparia borni Biozone in the whole of southwestern Europe. The correlation of the trilobite assemblages with those of other formations represented in the Cantabrian, West Asturian-leonese and Central Iberian zones is also discussed, the latter probably related through the enigmatic Central Iberian Arc, a debated orocline of the Iberian Massif.
Quantum computing based high-energy nuclear physics
Authors: Li Tian-Yin , Xing Hong-Xi , Zhang Dan-Bo ,   Key Laboratory of Atomic and Subatomic Structure and Quantum Control (Ministry of Education), Institute of Quantum Matter, South China Normal University, Guangzhou 510006, China,   Guangdong Provincial Key Laboratory of Nuclear Science, Institute of Quantum Matter, South China Normal University, Guangzhou 510006, China,   Guangdong-Hong Kong Joint Laboratory of Quantum Matter, Southern Nuclear Science Computing Center, South China Normal University, Guangzhou 510006, China,   Key Laboratory of Atomic and Subatomic Structure and Quantum Control (Ministry of Education), Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matter, School of Physics, South China Normal University, Guangzhou 510006, China
Published: July 2023

High-energy nuclear physics aims to explore and understand the physics of matter composed of quarks and gluons. However, it is intrinsically difficult to simulate high-energy nuclear physics from the first principle based quantum chromodynamics by using classical computers. In recent years, quantum computing has received intensive attention because it is expected to provide an ultimate solution for simulating high-energy nuclear physics. In this paper, we firstly review recent advances in quantum simulation of high-energy nuclear physics. Then we introduce some standard quantum algorithms, such as state preparation and measurements of light-cone correlation function. Finally, we demonstrate the advantage of quantum computing for solving the real-time evolution and the sign problems by studying hadronic scattering amplitude and phase structure of finite-temperature and finite-density matter, respectively.
Lipid homeostasis is essential for a maximal ER stress response
Authors: Garcia Gilberto , Zhang Hanlin , Moreno Sophia , Tsui C Kimberly , Webster Brant Michael , Higuchi-Sanabria Ryo , Dillin Andrew
Published: July 2023

Changes in lipid metabolism are associated with aging and age-related diseases, including proteopathies. The endoplasmic reticulum (ER) is uniquely a major hub for protein and lipid synthesis, making its function essential for both protein and lipid homeostasis. However, it is less clear how lipid metabolism and protein quality may impact each other. Here, we identified let-767, a putative hydroxysteroid dehydrogenase in Caenorhabditis elegans, as an essential gene for both lipid and ER protein homeostasis. Knockdown of let-767 reduces lipid stores, alters ER morphology in a lipid-dependent manner, and blocks induction of the Unfolded Protein Response of the ER (UPRER). Interestingly, a global reduction in lipogenic pathways restores UPRER induction in animals with reduced let-767. Specifically, we find that supplementation of 3-oxoacyl, the predicted metabolite directly upstream of let-767, is sufficient to block induction of the UPRER. This study highlights a novel interaction through which changes in lipid metabolism can alter a cell’s response to protein-induced stress.
Melanocortin 1 receptor regulates cholesterol and bile acid metabolism in the liver
Authors: Thapa Keshav , Kadiri James J , Saukkonen Karla , Pennanen Iida , Ghimire Bishwa , Cai Minying , Savontaus Eriika , Rinne Petteri
Published: July 2023

Melanocortin 1 receptor (MC1-R) is widely expressed in melanocytes and leukocytes and is thus strongly implicated in the regulation of skin pigmentation and inflammation. MC1-R has also been found in the rat and human liver, but its functional role has remained elusive. We hypothesized that MC1-R is functionally active in the liver and involved in the regulation of cholesterol and bile acid metabolism. We generated hepatocyte-specific MC1-R knock-out (Mc1r LKO) mice and phenotyped the mouse model for lipid profiles, liver histology, and bile acid levels. Mc1r LKO mice had significantly increased liver weight, which was accompanied by elevated levels of total cholesterol and triglycerides in the liver as well as in the plasma. These mice demonstrated also enhanced liver fibrosis and a disturbance in bile acid metabolism as evidenced by markedly reduced bile acid levels in the plasma and feces. Mechanistically, using HepG2 cells as an in vitro model, we found that selective activation of MC1-R in HepG2 cells reduced cellular cholesterol content and enhanced uptake of low- and high-density lipoprotein particles via a cAMP-independent mechanism. In conclusion, the present results demonstrate that MC1-R signaling in hepatocytes regulates cholesterol and bile acid metabolism and its deficiency leads to hypercholesterolemia and enhanced lipid accumulation and fibrosis in the liver.
Molecular basis of interactions between CaMKII and α-actinin-2 that underlie dendritic spine enlargement
Authors: Curtis Ashton J , Zhu Jian , Penny Christopher J , Gold Matthew G
Published: July 2023

Ca2+/calmodulin-dependent protein kinase II (CaMKII) is essential for long-term potentiation (LTP) of excitatory synapses that is linked to learning and memory. In this study, we focused on understanding how interactions between CaMKIIα and the actin-crosslinking protein α-actinin-2 underlie long-lasting changes in dendritic spine architecture. We found that association of the two proteins was unexpectedly elevated within 2 minutes of NMDA receptor stimulation that triggers structural LTP in primary hippocampal neurons. Furthermore, disruption of interactions between the two proteins prevented the accumulation of enlarged mushroom-type dendritic spines following NMDA receptor activation. α-Actinin-2 binds to the regulatory segment of CaMKII. Calorimetry experiments, and a crystal structure of α-actinin-2 EF hands 3 and 4 in complex with the CaMKII regulatory segment, indicate that the regulatory segment of autoinhibited CaMKII is not fully accessible to α-actinin-2. Pull-down experiments show that occupation of the CaMKII substrate-binding groove by GluN2B markedly increases α-actinin-2 access to the CaMKII regulatory segment. Furthermore, in situ labelling experiments are consistent with the notion that recruitment of CaMKII to NMDA receptors contributes to elevated interactions between the kinase and α-actinin-2 during structural LTP. Overall, our study provides new mechanistic insight into the molecular basis of structural LTP and reveals an added layer of sophistication to the function of CaMKII.
ECS1 and ECS2 suppress polyspermy and the formation of haploid plants by promoting double fertilization
Authors: Mao Yanbo , Nakel Thomas , Erbasol Serbes Isil , Joshi Saurabh , Tekleyohans Dawit G , Baum Thomas , Groß-Hardt Rita
Published: July 2023

The current pace of crop plant optimization is insufficient to meet future demands and there is an urgent need for novel breeding strategies. It was previously shown that plants tolerate the generation of triparental polyspermy-derived plants and that polyspermy can bypass hybridization barriers. Polyspermy thus has the potential to harness previously incompatible climate-adapted wild varieties for plant breeding. However, factors that influence polyspermy frequencies were not previously known. The endopeptidases ECS1 and ECS2 have been reported to prevent the attraction of supernumerary pollen tubes by cleaving the pollen tube attractant LURE1. Here, we show that these genes have an earlier function that is manifested by incomplete double fertilization in plants defective for both genes. In addition to supernumerary pollen tube attraction, ecs1 ecs2 mutants exhibit a delay in synergid disintegration, are susceptible to heterofertilization, and segregate haploid plants that lack a paternal genome contribution. Our results thus uncover ECS1 and ECS2 as the first female factors triggering the induction of maternal haploids. Capitalizing on a high-throughput polyspermy assay, we in addition show that the double mutant exhibits an increase in polyspermy frequencies. As both haploid induction and polyspermy are valuable breeding aims, our results open new avenues for accelerated generation of climate-adapted cultivars.
Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes
Authors: Ma Liang , Singh Jasleen , Schekman Randy
Published: July 2023

Fusion of multivesicular bodies (MVBs) with the plasma membrane results in the secretion of intraluminal vesicles (ILVs), or exosomes. The sorting of one exosomal cargo RNA, miR223, is facilitated by the RNA-binding protein, YBX1 (Shurtleff et al., 2016). We found that miR223 specifically binds a ‘cold shock’ domain (CSD) of YBX1 through a 5’ proximal sequence motif UCAGU that may represent a binding site or structural feature required for sorting. Prior to sorting into exosomes, most of the cytoplasmic miR223 resides in mitochondria. An RNA-binding protein localized to the mitochondrial matrix, YBAP1, appears to serve as a negative regulator of miR223 enrichment into exosomes. miR223 levels decreased in the mitochondria and increased in exosomes after loss of YBAP1. We observed YBX1 shuttle between mitochondria and endosomes in live cells. YBX1 also partitions into P body granules in the cytoplasm (Liu et al., 2021). We propose a model in which miR223 and likely other miRNAs are stored in mitochondria and are then mobilized by YBX1 to cytoplasmic phase condensate granules for capture into invaginations in the endosome that give rise to exosomes.
An in vitro model for vitamin A transport across the human blood–brain barrier
Authors: Est Chandler B , Murphy Regina M
Published: July 2023

Vitamin A, supplied by the diet, is critical for brain health, but little is known about its delivery across the blood–brain barrier (BBB). Brain microvascular endothelial-like cells (BMECs) differentiated from human-derived induced pluripotent stem cells (iPSCs) form a tight barrier that recapitulates many of the properties of the human BBB. We paired iPSC-derived BMECs with recombinant vitamin A serum transport proteins, retinol-binding protein (RBP), and transthyretin (TTR), to create an in vitro model for the study of vitamin A (retinol) delivery across the human BBB. iPSC-derived BMECs display a strong barrier phenotype, express key vitamin A metabolism markers, and can be used for quantitative modeling of retinol accumulation and permeation. Manipulation of retinol, RBP, and TTR concentrations, and the use of mutant RBP and TTR, yielded novel insights into the patterns of retinol accumulation in, and permeation across, the BBB. The results described herein provide a platform for deeper exploration of the regulatory mechanisms of retinol trafficking to the human brain.
Identifying metabolic features of colorectal cancer liability using Mendelian randomization
Authors: Bull Caroline , Hazelwood Emma , Bell Joshua A , Tan Vanessa , Constantinescu Andrei-Emil , Borges Carolina , Legge Danny , Burrows Kimberley , Huyghe Jeroen R , Brenner Hermann , Castellvi-Bel Sergi , Chan Andrew T , Kweon Sun-Seog , Le Marchand Loic , Li Li , Cheng Iona , Pai Rish K , Figueiredo Jane C , Murphy Neil , Gunter Marc J , Timpson Nicholas J , Vincent Emma E
Published: July 2023

Background:

Recognizing the early signs of cancer risk is vital for informing prevention, early detection, and survival.

Methods:

To investigate whether changes in circulating metabolites characterize the early stages of colorectal cancer (CRC) development, we examined the associations between a genetic risk score (GRS) associated with CRC liability (72 single-nucleotide polymorphisms) and 231 circulating metabolites measured by nuclear magnetic resonance spectroscopy in the Avon Longitudinal Study of Parents and Children (N = 6221). Linear regression models were applied to examine the associations between genetic liability to CRC and circulating metabolites measured in the same individuals at age 8 y, 16 y, 18 y, and 25 y.

Results:

The GRS for CRC was associated with up to 28% of the circulating metabolites at FDR-P < 0.05 across all time points, particularly with higher fatty acids and very-low- and low-density lipoprotein subclass lipids. Two-sample reverse Mendelian randomization (MR) analyses investigating CRC liability (52,775 cases, 45,940 controls) and metabolites measured in a random subset of UK Biobank participants (N = 118,466, median age 58 y) revealed broadly consistent effect estimates with the GRS analysis. In conventional (forward) MR analyses, genetically predicted polyunsaturated fatty acid concentrations were most strongly associated with higher CRC risk.

Conclusions:

These analyses suggest that higher genetic liability to CRC can cause early alterations in systemic metabolism and suggest that fatty acids may play an important role in CRC development.

Funding:

This work was supported by the Elizabeth Blackwell Institute for Health Research, University of Bristol, the Wellcome Trust, the Medical Research Council, Diabetes UK, the University of Bristol NIHR Biomedical Research Centre, and Cancer Research UK. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This work used the computational facilities of the Advanced Computing Research Centre, University of Bristol - http://www.bristol.ac.uk/acrc/.