bluuebunny/crossref_metadata_2025 huggingface dataset:
Convergence and Numerical Solution of a Model for Tumor Growth
Authors: Benito Juan J. , García Ángel , Gavete María Lucía , Negreanu Mihaela , Ureña Francisco , Vargas Antonio M.
Published: June 2021

In this paper, we show the application of the meshless numerical method called “Generalized Finite Diference Method” (GFDM) for solving a model for tumor growth with nutrient density, extracellular matrix and matrix degrading enzymes, [recently proposed by Li and Hu]. We derive the discretization of the parabolic–hyperbolic–parabolic–elliptic system by means of the explicit formulae of the GFDM. We provide a theoretical proof of the convergence of the spatial–temporal scheme to the continuous solution and we show several examples over regular and irregular distribution of points. This shows the feasibility of the method for solving this nonlinear model appearing in Biology and Medicine in complicated and realistic domains.
Extended Hamilton–Jacobi Theory, Symmetries and Integrability by Quadratures
Authors: Grillo Sergio , Marrero Juan Carlos , Padrón Edith
Published: June 2021

In this paper, we study the extended Hamilton–Jacobi Theory in the context of dynamical systems with symmetries. Given an action of a Lie group G on a manifold M and a G-invariant vector field X on M, we construct complete solutions of the Hamilton–Jacobi equation (HJE) related to X (and a given fibration on M). We do that along each open subset U⊆M, such that πU has a manifold structure and πU:U→πU, the restriction to U of the canonical projection π:M→M/G, is a surjective submersion. If XU is not vertical with respect to πU, we show that such complete solutions solve the reconstruction equations related to XU and G, i.e., the equations that enable us to write the integral curves of XU in terms of those of its projection on πU. On the other hand, if XU is vertical, we show that such complete solutions can be used to construct (around some points of U) the integral curves of XU up to quadratures. To do that, we give, for some elements ξ of the Lie algebra g of G, an explicit expression up to quadratures of the exponential curve expξt, different to that appearing in the literature for matrix Lie groups. In the case of compact and of semisimple Lie groups, we show that such expression of expξt is valid for all ξ inside an open dense subset of g.
High Performance Mixed-Matrix Electrospun Membranes for Ammonium Removal from Wastewaters
Authors: Chen Shu-Ting , Wickramasinghe Sumith Ranil , Qian Xianghong
Published: June 2021

Mixed-matrix electrospun membranes were developed to investigate ammonium removal from low ammonium concentration wastewaters for the first time. Particles derived from the inexpensive zeolite 13X were successfully incorporated into polyethersulfone (PES) matrices. The fabricated mixed-matrix electrospun membranes demonstrate high ammonium removal capacity reaching over 55 mg/gzeolite, more than 2.5 times higher than the previously fabricated mixed-matrix membranes via non-solvent induced phase inversion. Moreover, the membranes fabricated exhibit high permeability and ease of regeneration. Over 90% of total ammonium nitrogen (TAN) can be removed from low TAN wastewaters such as aquaculture wastewaters. In addition to zeolite 13X, other zeolite particles including zeolite Y, zeolite 3A and 4A were also incorporated into the membrane matrix. The inexpensive zeolite 13X show the highest ammonium exchange capacity. Particle type, loading and the level of its dispersion all affect TAN removal capacity.
Evaluation of Hardness, Sliding Wear and Strength of a Hypoeutectic White Iron with 25%Cr after Heat Treatments
Authors: González-Pociño Alejandro , Asensio-Lozano Juan , Álvarez-Antolín Florentino , García-Diez Ana
Published: June 2021

Hypoeutectic white cast irons with a high chrome content are commonly used in the industrial mining sector where there is a demand for both high resistance to adhesive wear and an acceptable toughness for the absorption of impacts and falls of diverse materials. Through the application of a design of experiment (DoE) technique, factors related to thermal treatment are analyzed with respect to resistance to sliding wear, maximum rupture stress and toughness. The results show that, in order to increase resistance to adhesive wear, it is convenient to use destabilization temperatures of 1050 °C and tempering of two hours at 400 °C. This foments a very hard martensite and a high proportion of highly alloyed retained austenite, which, with low tempering, achieves a precipitation of carbides from this austenite with hardly any loss of hardness of the martensite. In order to increase the energy which this material is capable of absorbing until breakage, furnace cooling set at 150 °C followed by tempering at 550 °C would be favorable. Slower cooling implies a greater quantity of conditioned retained austenite, so that, following this, it may be transformed into lower bainite with a high density of finely dispersed precipitated carbides. Furthermore, this tempering also allows the transformation of martensite into ferrite with finely dispersed carbides.
Study of Microbial Cultures for the Bioleaching of Scandium from Alumina Industry By-Products
Authors: Kiskira Kyriaki , Lymperopoulou Theopisti , Tsakanika Lamprini-Areti , Pavlopoulos Charalampos , Papadopoulou Konstantina , Ochsenkühn Klaus-Michael , Lyberatos Gerasimos , Ochsenkühn-Petropoulou Maria
Published: June 2021

The disposal of voluminous, highly alkaline, bauxite residue (BR), the industrial by-product of alumina production by the Bayer process, constitutes an intricate global environmental problem. BR, containing valuable metals such as rare-earth elements (REEs)—in particular, scandium (Sc)—can be used as a secondary source for REE extraction. The scope of this study was the investigation of bioleaching as an innovative and environmentally friendly approach for the extraction of Sc from BR. The bioleaching parameters were studied on Greek BR and experiments were performed using different microbial cultures and solid to liquid ratios (S/L). The maximum extraction of Sc was 42% using Acetobacter tropicalis in a one-step bioleaching process at 1% S/L. The main organic acids produced were acetic, oxalic, and citric. The bioleaching data indicated a probable synergistic effect of the different organic acids produced by microorganisms along with a more targeted leaching mechanism.
High-Accuracy Surface Topography Manufacturing for Continuous Phase Plates Using an Atmospheric Pressure Plasma Jet
Authors: Jin Huiliang , Tang Caixue , Li Haibo , Zhang Yuanhang , Li Yaguo
Published: June 2021

The continuous phase plate (CPP) is the vital diffractive optical element involved in laser beam shaping and smoothing in high-power laser systems. The high gradients, small spatial periods, and complex features make it difficult to achieve high accuracy when manufacturing such systems. A high-accuracy and high-efficiency surface topography manufacturing method for CPP is presented in this paper. The atmospheric pressure plasma jet (APPJ) system is presented and the removal characteristics are studied to obtain the optimal processing parameters. An optimized iterative algorithm based on the dwell point matrix and a fast Fourier transform (FFT) is proposed to improve the accuracy and efficiency in the dwell time calculation process. A 120 mm × 120 mm CPP surface topography with a 1326.2 nm peak-to-valley (PV) value is fabricated with four iteration steps after approximately 1.6 h of plasma processing. The residual figure error between the prescribed surface topography and plasma-processed surface topography is 28.08 nm root mean square (RMS). The far-field distribution characteristic of the plasma-fabricated surface is analyzed, for which the energy radius deviation is 11 μm at 90% encircled energy. The experimental results demonstrates the potential of the APPJ approach for the manufacturing of complex surface topographies.
Transendothelial Electrical Resistance Measurement across the Blood–Brain Barrier: A Critical Review of Methods
Authors: Vigh Judit P. , Kincses András , Ozgür Burak , Walter Fruzsina R. , Santa-Maria Ana Raquel , Valkai Sándor , Vastag Mónika , Neuhaus Winfried , Brodin Birger , Dér András , Deli Mária A.
Published: June 2021

The blood–brain barrier (BBB) represents the tightest endothelial barrier within the cardiovascular system characterized by very low ionic permeability. Our aim was to describe the setups, electrodes, and instruments to measure electrical resistance across brain microvessels and culture models of the BBB, as well as critically assess the influence of often neglected physical and technical parameters such as temperature, viscosity, current density generated by different electrode types, surface size, circumference, and porosity of the culture insert membrane. We demonstrate that these physical and technical parameters greatly influence the measurement of transendothelial electrical resistance/resistivity (TEER) across BBB culture models resulting in severalfold differences in TEER values of the same biological model, especially in the low-TEER range. We show that elevated culture medium viscosity significantly increases, while higher membrane porosity decreases TEER values. TEER data measured by chopstick electrodes can be threefold higher than values measured by chamber electrodes due to different electrode size and geometry, resulting in current distribution inhomogeneity. An additional shunt resistance at the circumference of culture inserts results in lower TEER values. A detailed description of setups and technical parameters is crucial for the correct interpretation and comparison of TEER values of BBB models.
MPLA and AddaVax® Adjuvants Fail to Promote Intramuscular LaAg Vaccine Protectiveness against Experimental Cutaneous Leishmaniasis
Authors: Oliveira-Maciel Diogo , dos-Santos Júlio Souza , Oliveira-Silva Gabriel , Mello Mirian França de , da Fonseca-Martins Alessandra Marcia , Carneiro Monique Pacheco Duarte , Ramos Tadeu Diniz , Firmino-Cruz Luan , Gomes Daniel Claudio Oliveira , Rossi-Bergmann Bartira , de Matos Guedes Herbert Leonel
Published: June 2021

There is so far no vaccine approved for human leishmaniasis, mainly because of the lack of appropriate adjuvants. This study aimed to evaluate in mice the capacity of a mixture of monophosphoryl lipid A (MPLA) and AddaVax® adjuvants in enhancing the efficacy of a Leishvacin®-like vaccine comprised of Leishmania amazonensis whole antigens (LaAg). For that, mice were immunized with LaAg plus MPLA/AddaVax® by the intramuscular route (i.m.) prior to challenge with 2 × 105 and 2 × 106 living parasites. Immunization with LaAg alone reduced the lesion growth of the 2 × 105-challenged mice only in the peak of infection, but that was not accompanied by reduced parasite load, and thus not considered protective. Mice given a 2 × 106 -challenge were not protected by LaAg. The association of LaAg with MPLA/AddaVax® was able to enhance the cutaneous hypersensitivity response compared with LaAg alone. Despite this, there was no difference in proliferative cell response to antigen ex vivo. Moreover, regardless of the parasite challenge, association of LaAg with MPL/AddaVax® did not significantly enhance protection in comparison with LaAg alone. This work demonstrated that MPL/AddaVax® is not effective in improving the efficacy of i.m. LaAg vaccine against cutaneous leishmaniasis.
Inoculation with Mycorrhizal Fungi and Irrigation Management Shape the Bacterial and Fungal Communities and Networks in Vineyard Soils
Authors: Torres Nazareth , Yu Runze , Kurtural S. Kaan
Published: June 2021

Vineyard-living microbiota affect grapevine health and adaptation to changing environments and determine the biological quality of soils that strongly influence wine quality. However, their abundance and interactions may be affected by vineyard management. The present study was conducted to assess whether the vineyard soil microbiome was altered by the use of biostimulants (arbuscular mycorrhizal fungi (AMF) inoculation vs. non-inoculated) and/or irrigation management (fully irrigated vs. half irrigated). Bacterial and fungal communities in vineyard soils were shaped by both time course and soil management (i.e., the use of biostimulants and irrigation). Regarding alpha diversity, fungal communities were more responsive to treatments, whereas changes in beta diversity were mainly recorded in the bacterial communities. Edaphic factors rarely influence bacterial and fungal communities. Microbial network analyses suggested that the bacterial associations were weaker than the fungal ones under half irrigation and that the inoculation with AMF led to the increase in positive associations between vineyard-soil-living microbes. Altogether, the results highlight the need for more studies on the effect of management practices, especially the addition of AMF on cropping systems, to fully understand the factors that drive their variability, strengthen beneficial microbial networks, and achieve better soil quality, which will improve crop performance.
Port Sediments: Problem or Resource? A Review Concerning the Treatment and Decontamination of Port Sediments by Fungi and Bacteria
Authors: Cecchi Grazia , Cutroneo Laura , Di Piazza Simone , Besio Giovanni , Capello Marco , Zotti Mirca
Published: June 2021

Contamination of marine sediments by organic and/or inorganic compounds represents one of the most critical problems in marine environments. This issue affects not only biodiversity but also ecosystems, with negative impacts on sea water quality. The scientific community and the European Commission have recently discussed marine environment and ecosystem protection and restoration by sustainable green technologies among the main objectives of their scientific programmes. One of the primary goals of sustainable restoration and remediation of contaminated marine sediments is research regarding new biotechnologies employable in the decontamination of marine sediments, to consider sediments as a resource in many fields such as industry. In this context, microorganisms—in particular, fungi and bacteria—play a central and crucial role as the best tools of sustainable and green remediation processes. This review, carried out in the framework of the Interreg IT-FR Maritime GEREMIA Project, collects and shows the bioremediation and mycoremediation studies carried out on marine sediments contaminated with ecotoxic metals and organic pollutants. This work evidences the potentialities and limiting factors of these biotechnologies and outlines the possible future scenarios of the bioremediation of marine sediments, and also highlights the opportunities of an integrated approach that involves fungi and bacteria together.
Cadmium Uptake and Growth Responses of Potted Vegetables to the Cd-Contaminated Soil Inoculated with Cd-Tolerant Purpureocillium lilacinum N1
Authors: Deng Yan , Huang Haonan , Fu Shaodong , Jiang Luhua , Liang Yili , Liu Xueduan , Jiang Huidan , Liu Hongwei
Published: June 2021

Bioremediation of Cd- (cadmium) contaminated soil using Cd-tolerant fungus is considered an eco-friendly and cost-effective technique. In this study, we isolated one fungal strain that was hyper-tolerant to Cd from a highly polluted river and conducted pot experiments to evaluate its effects on bioremediation. We found that the fungal strain belonging to the genus, Purpureocillium lilacinum, tolerated 12,000 mg/L Cd. SEM manifested that Cd can be bioaccumulated on the crumpled mycelial surface, generating plenty of metal precipitation particles. In addition, pot experiments showed that the inoculation of P. lilacinum N1 could reduce the total Cd content in soil (2.09% in low contaminated soil and 12.56% in high contaminated soil) and greatly promote plant growth (2.16~3.13 times). Although the Cd concentration of plants was increased by 112.8% in low contaminated soil and decreased by 9.5% in highly contaminated soil with the inoculation of P. lilacinum N1, the total uptake of Cd by plants was greatly improved—1.84~3.6 times higher than that in CK groups. All our results suggest that P. lilacinum N1 is a valuable candidate for the bioremediation of Cd-contaminated soils because of its dual effects on the total Cd content in soil and Cd uptake in plants.
Full-Scale Simulation and Validation of Wear for a Mining Rope Shovel Bucket
Authors: Svanberg Andreas , Larsson Simon , Mäki Rikard , Jonsén Pär
Published: June 2021

Failure in industrial processes is often related to wear and can cause significant problems. It is estimated that approximately 1–4% of the gross national product for an industrialized nation is related to abrasive wear. This work aims to numerically predict development of wear for full-scale mining applications in harsh sub-arctic conditions. The purpose is to increase the understanding of wear development in industrial processes and optimize service life and minimize costs related to wear. In the present paper, a granular material model consisting of the discrete element method (DEM) and rigid finite element particles is utilized to study wear in full-scale mining applications where granular materials and steel structures are present. A wear model with the basis in Finnie’s wear model is developed to calculate wear from combined abrasive sliding and impact wear. Novel in situ full-scale experiments are presented for calibration of the wear model. A simulation model of the rope shovel loading process is set up where the bucket filling process is simulated several times, and the wear is calculated with the calibrated wear model. From the full-scale validation, it is shown that the simulated wear is in excellent agreement when compared to the experiments, both regarding wear locations and magnitudes. After validation, the model is utilized to study if wear can be minimized by making small changes to the bucket. One major conclusion from the work is that the presented wear simulator is a suitable tool that can be used for product development and optimization of the loading process.
Structural Studies of Aluminated form of Zeolites—EXAFS and XRD Experiment, STEM Micrography, and DFT Modelling
Authors: Jajko Gabriela , Kozyra Paweł , Strzempek Maciej , Indyka Paulina , Zając Marcin , Witkowski Stefan , Piskorz Witold
Published: June 2021

In this article, the results of computational structural studies on Al-containing zeolites, via periodic DFT + D modelling and FDM (Finite Difference Method) to solve the Schrödinger equation (FDMNES) for XAS simulations, corroborated by EXAFS (Extended X-ray Absorption Fine Structure) spectroscopy and PXRD (powder X-ray diffractometry), are presented. The applicability of Radial Distribution Function (RDF) to screen out the postulated zeolite structure is also discussed. The structural conclusions are further verified by HR-TEM imaging.
The Effects of Food on Cannabidiol Bioaccessibility
Authors: Mozaffari Khadijeh , Willette Stephanie , Lucker Ben F. , Kovar Sarah E. , Holguin Francisco Omar , Guzman Ivette
Published: June 2021

Cannabidiol (CBD) is a hydrophobic non-psychoactive compound with therapeutic characteristics. Animal and human studies have shown its poor oral bioavailability in vivo, and the impact of consuming lipid-soluble CBD with and without food on gut bioaccessibility has not been explored. The purpose of this research was to study the bioaccessibility of CBD after a three-phase upper digestion experiment with and without food, and to test lipase activity with different substrate concentrations. Our results showed that lipase enzyme activity and fatty acid absorption increased in the presence of bile salts, which may also contribute to an increase in CBD bioaccessibility. The food matrix used was a mixture of olive oil and baby food. Overall, the fed-state digestion revealed significantly higher micellarization efficiency for CBD (14.15 ± 0.6% for 10 mg and 22.67 ± 2.1% for 100 mg CBD ingested) than the fasted state digestion of CBD (0.65 ± 0.7% for 10 mg and 0.14 ± 0.1% for 100 mg CBD ingested). The increase in bioaccessibility of CBD with food could be explained by the fact that micelle formation from hydrolyzed lipids aid in bioaccessibility of hydrophobic molecules. In conclusion, the bioaccessibility of CBD depends on the food matrix and the presence of lipase and bile salts.
Isobornylchalcones as Scaffold for the Synthesis of Diarylpyrazolines with Antioxidant Activity
Authors: Popova Svetlana A. , Pavlova Evgenia V. , Shevchenko Oksana G. , Chukicheva Irina Yu. , Kutchin Aleksandr V.
Published: June 2021

The pyrazoline ring is defined as a “privileged structure” in medicinal chemistry. A variety of pharmacological properties of pyrazolines is associated with the nature and position of various substituents, which is especially evident in diarylpyrazolines. Compounds with a chalcone fragment show a wide range of biological properties as well as high reactivity which is primarily due to the presence of an α, β-unsaturated carbonyl system. At the same time, bicyclic monoterpenoids deserve special attention as a source of a key structural block or as one of the pharmacophore components of biologically active molecules. A series of new diarylpyrazoline derivatives based on isobornylchalcones with different substitutes (MeO, Hal, NO2, N(Me)2) was synthesized. Antioxidant properties of the obtained compounds were comparatively evaluated using in vitro model Fe2+/ascorbate-initiated lipid peroxidation in the substrate containing brain lipids of laboratory mice. It was demonstrated that the combination of the electron-donating group in the para-position of ring B and OH-group in the ring A in the structure of chalcone fragment provides significant antioxidant activity of synthesized diarylpyrazoline derivatives.
Trends in the Use of Botanicals in Anti-Aging Cosmetics
Authors: Ferreira Marta , Magalhães Maria , Oliveira Rita , Sousa-Lobo José , Almeida Isabel
Published: June 2021

Botanical ingredients have been used for thousands of years in skincare for their convenience as well as the diversity and abundance in compounds with biological activity. Among these, polyphenols and especially flavonoids have gained increasing prominence due to their antioxidant and anti-inflammatory properties. In this study, the most used botanical preparations in anti-aging products marketed in 2011 were determined. The analysis was repeated in 2018 for new and reformulated products. The scientific evidence for their application as active ingredients in anti-aging cosmetics and their flavonoid content was also compiled by searching in online scientific databases. Overall, in 2018, there was a noticeable increase in the use of botanical preparations in anti-aging cosmetics. However, the top three botanical species in both years were Vitis vinifera, Butyrospermum parkii, and Glycine soja, which is consistent with the greater amount of scientific evidence supporting their efficacy. Regarding the function of botanical preparations, there is a clear preference for DNA-protecting ingredients. The most prevalent flavonoids were flavan-3-ols, proanthocyanidins, and anthocyanins. This study provided an updated overview of the market trends regarding the use of botanicals in anti-aging products and documented the state of the art of scientific evidence for the most used plants.
Prediction of African Swine Fever Virus Inhibitors by Molecular Docking-Driven Machine Learning Models
Authors: Choi Jiwon , Yun Jun Seop , Song Hyeeun , Shin Yong-Keol , Kang Young-Hoon , Munashingha Palinda Ruvan , Yoon Jeongyeon , Kim Nam Hee , Kim Hyun Sil , Yook Jong In , Tark Dongseob , Lim Yun-Sook , Hwang Soon B.
Published: June 2021

African swine fever virus (ASFV) causes a highly contagious and severe hemorrhagic viral disease with high mortality in domestic pigs of all ages. Although the virus is harmless to humans, the ongoing ASFV epidemic could have severe economic consequences for global food security. Recent studies have found a few antiviral agents that can inhibit ASFV infections. However, currently, there are no vaccines or antiviral drugs. Hence, there is an urgent need to identify new drugs to treat ASFV. Based on the structural information data on the targets of ASFV, we used molecular docking and machine learning models to identify novel antiviral agents. We confirmed that compounds with high affinity present in the region of interest belonged to subsets in the chemical space using principal component analysis and k-means clustering in molecular docking studies of FDA-approved drugs. These methods predicted pentagastrin as a potential antiviral drug against ASFVs. Finally, it was also observed that the compound had an inhibitory effect on AsfvPolX activity. Results from the present study suggest that molecular docking and machine learning models can play an important role in identifying potential antiviral drugs against ASFVs.
Self-Assembled Nanomaterials Based on Complementary Sn(IV) and Zn(II)-Porphyrins, and Their Photocatalytic Degradation for Rhodamine B Dye
Authors: Shee Nirmal K. , Kim Hee-Joon
Published: June 2021

A series of porphyrin triads (1–6), based on the reaction of trans-dihydroxo-[5,15-bis(3-pyridyl)-10,20-bis(phenyl)porphyrinato]tin(IV) (SnP) with six different phenoxy Zn(II)-porphyrins (ZnLn), was synthesized. The cooperative metal–ligand coordination of 3-pyridyl nitrogens in the SnP with the phenoxy Zn(II)-porphyrins, followed by the self-assembly process, leads to the formation of nanostructures. The red-shifts and remarkable broadening of the absorption bands in the UV–vis spectra for the triads in CHCl3 indicate that nanoaggregates may be produced in the self-assembly process of these triads. The emission intensities of the triads were also significantly reduced due to the aggregation. Microscopic analyses of the nanostructures of the triads reveal differences due to the different substituents on the axial Zn(II)-porphyrin moieties. All these nanomaterials exhibited efficient photocatalytic performances in the degradation of rhodamine B (RhB) dye under visible light irradiation, and the degradation efficiencies of RhB in aqueous solution were observed to be 72~95% within 4 h. In addition, the efficiency of the catalyst was not impaired, showing excellent recyclability even after being applied for the degradation of RhB in up to five cycles.
Effective Poly (Cyclotriphosphazene-Co-4,4′-Sulfonyldiphenol)@rGO Sheets for Tetracycline Adsorption: Fabrication, Characterization, Adsorption Kinetics and Thermodynamics
Authors: Ahmad Muhammad , Nawaz Tehseen , Alam Mohammad Mujahid , Abbas Yasir , Ali Shafqat , Imran Muhammad , Zhang Shuangkun , Wu Zhanpeng
Published: June 2021

The development of excellent drug adsorbents and clarifying the interaction mechanisms between adsorbents and adsorbates are greatly desired for a clean environment. Herein, we report that a reduced graphene oxide modified sheeted polyphosphazene (rGO/poly (cyclotriphosphazene-co-4,4′-sulfonyldiphenol)) defined as PZS on rGO was used to remove the tetracycline (TC) drug from an aqueous solution. Compared to PZS microspheres, the adsorption capacity of sheeted PZS@rGO exhibited a high adsorption capacity of 496 mg/g. The adsorption equilibrium data well obeyed the Langmuir isotherm model, and the kinetics isotherm was fitted to the pseudo-second-order model. Thermodynamic analysis showed that the adsorption of TC was an exothermic, spontaneous process. Furthermore, we highlighted the importance of the surface modification of PZS by the introduction of rGO, which tremendously increased the surface area necessary for high adsorption. Along with high surface area, electrostatic attractions, H-bonding, π-π stacking and Lewis acid-base interactions were involved in the high adsorption capacity of PZS@rGO. Furthermore, we also proposed the mechanism of TC adsorption via PZS@rGO.
Recent Advances in Two-Dimensional Quantum Dots and Their Applications
Authors: James Singh Konthoujam , Ahmed Tanveer , Gautam Prakalp , Sadhu Annada Sankar , Lien Der-Hsien , Chen Shih-Chen , Chueh Yu-Lun , Kuo Hao-Chung
Published: June 2021

Two-dimensional quantum dots have received a lot of attention in recent years due to their fascinating properties and widespread applications in sensors, batteries, white light-emitting diodes, photodetectors, phototransistors, etc. Atomically thin two-dimensional quantum dots derived from graphene, layered transition metal dichalcogenide, and phosphorene have sparked researchers’ interest with their unique optical and electronic properties, such as a tunable energy bandgap, efficient electronic transport, and semiconducting characteristics. In this review, we provide in-depth analysis of the characteristics of two-dimensional quantum dots materials, their synthesis methods, and opportunities and challenges for novel device applications. This analysis will serve as a tipping point for learning about the recent breakthroughs in two-dimensional quantum dots and motivate more scientists and engineers to grasp two-dimensional quantum dots materials by incorporating them into a variety of electrical and optical fields.
Potential Role of Probiotics in Ameliorating Psoriasis by Modulating Gut Microbiota in Imiquimod-Induced Psoriasis-Like Mice
Authors: Lu Wenwei , Deng Yadan , Fang Zhifeng , Zhai Qixiao , Cui Shumao , Zhao Jianxin , Chen Wei , Zhang Hao
Published: June 2021

Psoriasis is an immune-mediated systemic disease that may be treated with probiotics. In this study, probiotic strains that could or could not decrease interleukin (IL)-17 levels were applied to imiquimod (IMQ)-induced psoriasis-like mice via oral administration. Bifidobacterium adolescentis CCFM667, B. breve CCFM1078, Lacticaseibacillus paracasei CCFM1074, and Limosilactobacillus reuteri CCFM1132 ameliorated psoriasis-like pathological characteristics and suppressed the release of IL-23/T helper cell 17 (Th17) axis-related inflammatory cytokines, whereas B. animalis CCFM1148, L. paracasei CCFM1147, and L. reuteri CCFM1040 neither alleviated the pathological characteristics nor reduced the levels of inflammatory cytokines. All effective strains increased the contents of short-chain fatty acids, which were negatively correlated with the levels of inflammatory cytokines. By performing 16S rRNA gene sequencing, the diversity of gut microbiota in psoriasis-like mice was found to decrease, but all effective strains made some specific changes to the composition of gut microbiota compared to the ineffective strains. Furthermore, except for B. breve CCFM1078, all other effective strains decreased the abundance of the family Rikenellaceae, which was positively correlated with psoriasis-like pathological characteristics and was negatively correlated with propionate levels. These findings demonstrated effects of strain-specificity, and how probiotics ameliorated psoriasis and provide new possibilities for the treatment of psoriasis.
Association between the FTO SNP rs9939609 and Metabolic Syndrome in Chilean Children
Authors: Molina-Luque Rafael , Ulloa Natalia , Romero-Saldaña Manuel , Zilic Martin , Gleisner Andrea , Lanuza Fabián , Molina-Recio Guillermo
Published: June 2021

Background: The increasing prevalence of obesity in children has raised the incidence of Metabolic Syndrome (MetS) in this age group. Given the short- and long-term health impact of MetS, it is essential to prevent its onset by detecting its main triggers. Besides, genetic factors play an essential role in influencing which individuals within a population are most likely to develop obesity in response to a particular environment. In this regard, a common variation in the FTO gene is reproducibly associated with BMI and obesity from childhood and the genetic load has been linked to several cardiovascular risk factors, highlighting the FTO single nucleotide polymorphism (SNP) rs9939609. Therefore, this study aimed to establish the relationship between the FTO SNP rs9939609 and MetS. Methods: A cross-sectional study was carried out on 220 children from the Biobío region (Chile). MetS diagnosis was established through the modified Cook criteria, using prevalence ratios, COR curves, and linear regressions to determine its association with MetS and its components. Results: The prevalence of MetS was significantly increased among carriers of the risk allele (A): TT, 20.2%; TA, 25.4%; AA, 44.7% (p = 0.006). Also, the presence of A was associated with altered MetS-related variables. Conclusions: The FTO SNP rs9939609 was associated with a raised prevalence of MetS among A allele carriers, and was higher in the homozygous genotype (AA).
Vitamin D Status and Factors Associated with Vitamin D Deficiency during the First Year of Life in Preterm Infants
Authors: Jung Jae-Hun , Kim Eun-Ah , Lee Sang-Yoon , Moon Jung-Eun , Lee Eun-Joo , Park Sook-Hyun
Published: June 2021

We aimed to investigate the changes in vitamin D levels and factors associated with vitamin D deficiency (VDD) during the first year of life in Korean preterm infants. We enrolled 333 preterm infants who were born at Kyungpook National University Children’s Hospital between March 2013 and December 2019. 25-hydroxyvitamin D (25-OHD) levels and medical records were collected at birth, 6 months, and 12 months of age. The mean gestational age was 33.4 ± 2.3 weeks and mean 25-OHD levels at birth were 18.2 ± 13.5 ng/mL. The incidence of VDD was 82.8%, 30.6%, and 27.0% at birth, 6 months, and 12 months, respectively. The incidence of severe VDD (25-OHD < 10 ng/mL) was 31.5%, 1.5%, and 0%, at birth, 6 months, and 12 months, respectively. Among infants with severe VDD, the deficiency persisted in 49.6% at 6 months, and 35.3% at 12 months. The strongest predictor of VDD during follow-up was 25-OHD concentration at birth. Vitamin D supplementation at 400 IU/day did not affect vitamin D levels during the first year of life. Therefore, it is important to prevent neonatal VDD through maternal vitamin D supplementation during pregnancy. Further research is needed to determine the optimal vitamin D supplementation dose for Korean preterm infants.
Zinc and the Innovative Zinc-α2-Glycoprotein Adipokine Play an Important Role in Lipid Metabolism: A Critical Review
Authors: Banaszak Michalina , Górna Ilona , Przysławski Juliusz
Published: June 2021

Numerous studies indicate that zinc and the new zinc-related adipokine, zinc-α2-glycoprotein (ZAG), are involved in lipid metabolism. Excess body fat lowers blood concentrations of Zn and ZAG, leading not only to the development of obesity but also to other components of the metabolic syndrome. Zinc homeostasis disorders in the body negatively affect the lipid profile and cytokine secretion. Zinc appears to be a very important ZAG homeostasis regulator. The physiological effects of ZAG are related to lipid metabolism, but studies show that ZAG also affects glucose metabolism and is linked to insulin resistance. ZAG has a zinc binding site in its structure, which may indicate that ZAG mediates the effect of zinc on lipid metabolism. The review aimed to verify the available studies on the effects of zinc and ZAG on lipid metabolism. A literature review within the scope of this research area was conducted using articles available in PubMed (including MEDLINE), Web of Science and Cochrane Library databases. An analysis of available studies has shown that zinc improves hepatic lipid metabolism and has an impact on the lipid profile. Numerous studies have found that zinc supplementation in overweight individuals significantly reduced blood levels of total cholesterol, LDL (Low-density lipoprotein)cholesterol and triglycerides, potentially reducing cardiovascular morbidity and mortality. Some results also indicate that it increases HDL-C (High-density lipoprotein) cholesterol levels. ZAG has been shown to play a significant role in reducing obesity and improving insulin sensitivity, both in experimental animal model studies and in human studies. Furthermore, ZAG at physiologically relevant concentrations increases the release of adiponectin from human adipocytes. In addition, ZAG has been shown to inhibit in vitro leptin production. Further studies are needed to provide more data on the role of zinc and zinc-α2-glycoprotein.
Designer Benzodiazepines: A Review of Toxicology and Public Health Risks
Authors: Brunetti Pietro , Giorgetti Raffaele , Tagliabracci Adriano , Huestis Marilyn , Busardò Francesco
Published: June 2021

The rising use of designer benzodiazepines (DBZD) is a cat-and-mouse game between organized crime and law enforcement. Non-prohibited benzodiazepines are introduced onto the global drug market and scheduled as rapidly as possible by international authorities. In response, DBZD are continuously modified to avoid legal sanctions and drug seizures and generally to increase the abuse potential of the DBZD. This results in an unpredictable fluctuation between the appearance and disappearance of DBZD in the illicit market. Thirty-one DBZD were considered for review after consulting the international early warning database, but only 3-hydroxyphenazepam, adinazolam, clonazolam, etizolam, deschloroetizolam, diclazepam, flualprazolam, flubromazepam, flubromazolam, meclonazepam, phenazepam and pyrazolam had sufficient data to contribute to this scoping review. A total of 49 reports describing 1 drug offense, 2 self-administration studies, 3 outpatient department admissions, 44 emergency department (ED) admissions, 63 driving under the influence of drugs (DUID) and 141 deaths reported between 2008 and 2021 are included in this study. Etizolam, flualprazolam flubromazolam and phenazepam were implicated in the majority of adverse-events, drug offenses and deaths. However, due to a general lack of knowledge of DBZD pharmacokinetics and toxicity, and due to a lack of validated analytical methods, total cases are much likely higher. Between 2019 and April 2020, DBZD were identified in 48% and 83% of postmortem and DUID cases reported to the UNODC, respectively, with flualprazolam, flubromazolam and etizolam as the most frequently detected substances. DBZD toxicology, public health risks and adverse events are reported.
Nanoformulation Shows Cytotoxicity against Glioblastoma Cell Lines and Antiangiogenic Activity in Chicken Chorioallantoic Membrane
Authors: Dallemole Danieli Rosane , Terroso Thatiana , Alves Aline de Cristo Soares , Scholl Juliete Nathali , Onzi Giovana Ravizzoni , Cé Rodrigo , Paese Karina , Battastini Ana Maria Oliveira , Guterres Silvia Stanisçuaski , Figueiró Fabrício , Pohlmann Adriana Raffin
Published: June 2021

Glioblastoma (GB) is a histological and genetically heterogeneous brain tumor that is highly proliferative and vascularized. The prognosis is poor with currently available treatment. In this study, we evaluated the cytotoxicity and antiangiogenic activity of doxorubicin-loaded-chitosan-coated-arginylglycylaspartic acid-functionalized-poly(ε-caprolactone)-alpha bisabolol-LNC (AB-DOX-LNC-L-C-RGD). The nanoformulation was prepared by self-assembling followed by interfacial reactions, physicochemically characterized and evaluated in vitro against GB cell lines (U87MG and U138MG) and in vivo using the chicken chorioallantoic membrane assay (CAM). Spherical shape nanocapsules had a hydrodynamic mean diameter of 138 nm, zeta potential of +13.4 mV, doxorubicin encapsulation of 65%, and RGD conjugation of 92%. After 24 h of treatment (U87MG and U138MG), the median inhibition concentrations (IC50) were 520 and 490 nmol L−1 doxorubicin-equivalent concentrations, respectively. The treatment induced antiproliferative activity with S-phase cell-cycle arrest and apoptosis in the GB cells. Furthermore, after 48 h of exposure, evaluation of antiangiogenic activity (CAM) showed that the relative vessel growth following treatment with the nanocapsules was 5.4 times lower than that with the control treatment. The results support the therapeutic potential of the nanoformulation against GB and, thereby, pave the way for future preclinical studies.
Special Issue: “Plant Virus Epidemiology”
Authors: Janssen Dirk , Ruiz Leticia
Published: June 2021

We are pleased to present this Special Issue on the topic of “Plant virus Epidemiology” [...]
Synthesis and Conductivity Studies of Poly(Methyl Methacrylate) (PMMA) by Co-Polymerization and Blending with Polyaniline (PANi)
Authors: Abu Hassan Shaari Helyati , Ramli Muhammad Mahyiddin , Mohtar Mohd Nazim , Abdul Rahman Norizah , Ahmad Azizan
Published: June 2021

Poly(methyl methacrylate) (PMMA) is a lightweight insulating polymer that possesses good mechanical stability. On the other hand, polyaniline (PANi) is one of the most favorable conducting materials to be used, as it is easily synthesized, cost-effective, and has good conductivity. However, most organic solvents have restricted potential applications due to poor mechanical properties and dispersibility. Compared to PANi, PMMA has more outstanding physical and chemical properties, such as good dimensional stability and better molecular interactions between the monomers. To date, many research studies have focused on incorporating PANi into PMMA. In this review, the properties and suitability of PANi as a conducting material are briefly reviewed. The major parts of this paper reviewed different approaches to incorporating PANi into PMMA, as well as evaluating the modifications to improve its conductivity. Finally, the polymerization condition to prepare PMMA/PANi copolymer to improve its conductivity is also discussed.
Special Issue on “Green Technologies for Production Processes”
Authors: Cai Wei , Jiang Zhigang , Liu Conghu , Wang Yan
Published: June 2021

Numerous pathways and narratives have been developed to shed light on how society could transform its production systems in line with the aspirational targets of the Paris Agreement and Sustainable Development Goals [...]
CO2 Absorption Mechanism by Diamino Protic Ionic Liquids (DPILs) Containing Azolide Anions
Authors: Wang Xiao , Wu Congyi , Yang Dezhong
Published: June 2021

Protic ionic liquids have been regarded as promising materials to capture CO2, because they can be easily synthesized with an attractive capacity. In this work, we studied the CO2 absorption mechanism by protic ionic liquids (ILs) composed of diamino protic cations and azolide anions. Results of 1H nuclear magnetic resonance (NMR), 13C NMR, 2-D NMR and fourier-transform infrared (FTIR) spectroscopy tests indicated that CO2 reacted with the cations rather than with the anions. The possible reaction pathway between CO2 and azolide-based protic ILs is proposed, in which CO2 reacts with the primary amine group generated from the deprotonation of the cation by the azolide anion.
UVA-LED Technology’s Treatment Efficiency and Cost in a Competitive Trial Applied to the Photo-Fenton Treatment of Landfill Leachate
Authors: Tejera Javier , Gascó Antonio , Hermosilla Daphne , Alonso-Gomez Víctor , Negro Carlos , Blanco Ángeles
Published: June 2021

The objective of this trial was to assess the application of UVA-LED technology as an alternative source of irradiation for photo-Fenton processes, aiming to reduce treatment costs and provide a feasible treatment for landfill leachate. An optimized combination of coagulation with ferric chloride followed by photo-Fenton treatment of landfill leachate was optimized. Three different radiation sources were tested, namely, two conventional high-pressure mercury-vapor immersion lamps (100 W and 450 W) and a custom-designed 8 W 365 nm UVA-LED lamp. The proposed treatment combination resulted in very efficient degradation of landfill leachate (COD removal = 90%). The coagulation pre-treatment removed about 70% of the COD and provided the necessary amount of iron for the subsequent photo-Fenton treatment, and it further favored this process by acidifying the solution to an optimum initial pH of 2.8. The 90% removal of color improved the penetration of radiation into the medium and by extension improved treatment efficiency. The faster the Fenton reactions were, as determined by the stoichiometric optimum set-up reaction condition of [H2O2]0/COD0 = 2.125, the better were the treatment results in terms of COD removal and biodegradability enhancement because the chances to scavenge oxidant agents were limited. The 100 W lamp was the least efficient one in terms of final effluent quality and operational cost figures. UVA-LED technology, assessed as the application of an 8 W 365 nm lamp, provided competitive results in terms of COD removal, biodegradability enhancement, and operational costs (35–55%) when compared to the performance of the 450 W conventional lamp.
Appraisal of Households’ Knowledge and Perception towards E-Waste Management in Limpopo Province, South Africa
Authors: Uhunamure Solomon E. , Nethengwe Nthaduleni S. , Shale Karabo , Mudau Virginia , Mokgoebo Matjutla
Published: June 2021

The generation of electronic waste (e-waste) is increasing at an alarming rate in South Africa. This waste stream is also emanating from household appliances due to beneficial attributes accrued to the use of these electronic devices. At the same time, these devices are a source of concern considering the environmental impacts as well the threat of health hazards they possess to human wellbeing. In appraising household knowledge and perception on e-waste management in Limpopo Province of South Africa, 200 semi-structured, self-administered questionnaires were used in eliciting data from the participants. The results indicated that 76% of the respondents believed that e-waste streams have negatively affected their environment. Additionally, 85% of the survey households are willing to pay for the proper disposal of their e-waste. Furthermore, the results indicated a statistically significance between gender and knowledge on e-waste management (p-value 0.003) while there was no statistically significant difference between gender and perception (p-value 0.318) on e-waste management. Based on the results, the study recommends awareness and educational campaigns as a step in changing the perception of households on e-waste and environmental consciousness.
Bioethical Threads in the Reflection of Tibetan Refugees in India
Authors: Lisiecki Marcin
Published: June 2021

This article aims to trace and describe the bioethical threads in medical practice and the understanding of medicine among Tibetan refugees living in India. Taking up such a task results mainly from the fact that only traces of bioethical reflection are visible in Tibetan society, but without the awareness that it requires systematic reflection on its essence and changes that accompany modern medicine. I define the state of the discussion on Tibetan bioethics as preparadigmatic, i.e., one that precedes the recognition of the importance of bioethics and the elaboration of its basic concepts. In this paper, I will show how the Tibetan refugees today, in an unconscious way, approach bioethics, using the example of life-related topics, namely beginning and death. To this end, I chose topics such as abortion, fetal sex reassignment, euthanasia, and suicide. On this basis, I will indicate the main reasons that hinder the emergence of bioethics and those that may contribute to systematic discussions in the future. An introduction to Tibetan medicine will precede these considerations. I will show how medical traditions, especially the Rgyud bzhi text, are related to Tibetan Buddhism and opinions of the 14th Dalai Lama.
A Statistical Model of Fraud Risk in Financial Statements. Case for Romania Companies
Authors: Sabău (Popa) Andrada-Ioana , Mare Codruța , Safta Ioana Lavinia
Published: June 2021

Tax avoidance is one of the most frequent reasons for which companies tend to resort to creative accounting techniques. The purpose of the study is to identify which of the eight-variables from the Beneish influences the most or least the outcome of the final score, as a percent, by developing a statistical model. The sample was selected from the Bucharest Stock Exchange and consists of 66 companies traded on the main market, for the years 2015–2019. The results show that from the total of the eight variables, GMI (Gross Margin Index), AQI (Asset Quality Index), DEPI (Depreciation Index) and TATA (Total Accruals to Total Assets) are significantly influencing the probability to commit fraud. The developed model is validated with only 10% of the non-fraud companies being mistakenly considered as fraud based on our model and vice versa.