bluuebunny/crossref_metadata_2025 huggingface dataset:
Automated System for Managing Hospital Data Using RPA
Authors: H R Rachana
Published: July 2022

Abstract: Healthcare systems contain multiple difficult tasks and strict regulations that require a considerable amount of resource allocation which causes high cost of operation, slower process and inefficiency. Healthcare professionals can address these problems by using the strength of automation and RPA thereby patient satisfaction can be improved. QR codes are fast becoming the go-to method for many organizations and businesses around the world. The reason complex management systems are using QR codes to manage their businesses better is that QR codes can help organize the overwhelming data gathered from customer and, on the other hand, give out information to users where it is due. Hospitals are some of the most challenging and complex organizations to manage and maintain. There are many variables to consider when running a hospital, such as patients, doctors, staff, drugs, labs. Automating the existing manual process of admission through computer software and hardware is the aim of hospital management system which enables faster access and manipulation of the valuable information through QR code.
College Automation System Using IOT
Authors: Narkhede Puja
Published: July 2022

Abstract: College Automation System Using IOT Project will work on College Electrical Appliances Remote control and Improved Attendance System. It will include Automation of all the Electrical gadgets in the college. It will have Facial Recognition verified RFID Attendance system along with Appliances Remote Control System for every class so that admin can see all Incoming and Outgoing Students Record on the Web User Interface and can also control the Gadget switches through a click on their phone. Let us see how this College Automation System Project will work. College Automation System Project will help the college administrator. Administrator will able to get all the information regarding any faculty members on particular day and time. Admin panel will also able to edit the login display panel of teachers, staff members, students etc. Admin can add person, delete person, can give special permission. Teachers can also see list of students who comes under the category of attendance shortage and many more under this one roof
Comparing the Efficiency of Malware Detection in Android System
Authors: Sharma Badal
Published: July 2022

Abstract: Personal Digital Assistants are becoming fundamental in our lives. Android is perhaps the most well-known working framework. Android OS is far-reaching in the portable business today due to its easy and comprehensive engineering. Application clients will generally trust the Android Operating System to get information; however, it is being demonstrated that Android is more defenseless and eccentric. of concern. As a result of its open-source design, the Android OS is endless in the versatile business today. It is a wide assortment of uses and essential highlights. Application clients generally prefer Android OS to get information
Parametric Study on Underwater Corroded Steel Pipelines Rehabilitated Using FRP and ECC
Authors: Paul Ms. Feba , M. S. Ms. Jinu Darsh
Published: July 2022

Abstract: Offshore steel pipelines subjected to internal and external pressure undergo buckling due to axial compression. Retrofitting of corroded steel pipelines against buckling is necessary for their long life. The lightweight, high strength and corrosion resistance of Fibre Reinforced Polymers (FRP) make them ideally suited for quick and effective structural repairs of offshore steel pipelines. But FRP rehabilitation faces some disadvantages like brittle failure, debonding phenomenon, long term performance issues of composite structures etc. ECC as a composite material, have high ductility, durability, self-healing capacity, energy absorption capability and with multiple micro-cracks rather than localized cracks, thereby helps in preventing corrosion of steel structures. This paper presents an experimental study on ECC material properties and static analysis on different rehabilitated specimen using ECC, CFRP and GFRP. The analysis was carried out using ANSYS software
Analysis of Load Deformation Behaviour of CSFRC Arc Corbel Using ANSYS
Authors: K. P. Akshara , Thulasi Ms. Anju
Published: July 2022

Abstract: Corbels are the structural members that transfer the horizontal and vertical load from beams to wall or column element. Corbels projecting from the faces of reinforced concrete columns are extensively used in precast concrete construction to support the primary beam and girders. Corbels are structural members characterized by a shear span-to-depth ratio (a/d), generally lower than unity. Arc corbel has better stress performance than other shaped corbel and also bear the crane loads. It is provided to support rails and support the end spans of the double cantilever balanced reinforced concrete bridges. Corrugated Steel Fiber Reinforced Concrete(CSFRC) is a concrete with short, discrete lengths of steel fibers which are randomly dispersed. This paper illustrates the effect of shear span-to-depth ratio on load deformation behavior of Corrugated Steel Fiber Reinforced Concrete arc corbel. The structure thatgenerates comparatively small deformation within the applied load can be considered as relatively safe. Corrugated Steel Fiber Reinforced Concrete with 1% steel fiber is used in the current study. The shear span-todepth ratios adopted for the study are 0.1, 0.15, 0.2. The analysis of the structure has been carried out using ANSYS Software.
Seismic Analysis of Steel Building with Bracing
Authors: Alex Ms. Aradhya Anna , S Ms. Chaithra
Published: July 2022

Abstract: As we know that construction of steel buildings is popular nowadays. To protect buildings from earthquake by providing bracings are very common. Bracing help to resist the lateral load during earthquake. Bracings are providing in structure at various configuration. This paper illustrates the effect of new bracing configuration with existing x bracing configuration. The seismic analysis of the structure has been carried out using ETABS Software.
Pipe Line Inspection Robot
Authors: Alex Amal
Published: July 2022

Abstract: Pipelines are mainly constructed to transport all kinds of fluids and gases. Many accidents had occurred from fluid leaks because of cracks and corrosion of pipelines. To eliminate or minimize the accidents periodical inspection of pipelines should be done. Analysis and control of autonomous robot for pipeline inspection requires design and model of a robot equipped with the proper sensors. This project deals with the design, modelling (software) and simulation of pipeline inspection robot. The robot is an autonomous mobile robot. The robot is placed at the entrance of the pipe, by giving suitable commands it will move forward and inspect the defects inside the pipe. This inspection robot includes camera for visual inspection to identify the cracks and corrosion in pipe. It captures the inner images of the pipe for further investigation. This robot also includes a LIDAR sensor for mapping of the pipe. The mapping and navigation are all done in ROS (Robot Operating System) with help of Gazebo and Rviz. The design of the robot is created in Fusion 360 and then it is transferred into Gazebo. The simulation of robot is done in circular pipes.
Toxicity of Monocrotophos in Freshwater Bivalve, Lamellidens marginalis, Using Different Markers
Authors: Tank Lalit G.
Published: July 2022

Abstract: The present study was undertaken to evaluate the toxic effects of monocrotophos, a widely used organophosphorus pesticide, on Lamellidens marginalis with a wide battery of biomarkers consisting of AchE inhibition, lipid peroxidation, the levels of antioxidant enzymes, and histopathological changes. Animals were exposed to monocrotophos (52.36 mg/l) for four days. Malondialdehyde (MDA) values were measured as index of oxidation while Superoxide dismutase (SOD), Catalase (CAT), Glutathione s-Transferase (GST), and Glutathione-Reductase (GR) were measured as index of an antioxidant status. After exposure, a significant reduction of the capability to neutralize radicals was observed. Histopathological changes, such as fibrosis in gill filaments and hypertrophy in mucous cells of foot tissue, were observed after treatment. In a second series of experiment, exposed animals were there after transferred to clean water and kept in it up to 28 days to assess the recovery pattern. Significant recovery is observed in AchE and antioxidant enzymes. Oxidative damage observed after acute exposure indicate that mussels faced an oxidative challenge but were able to counteract, as values of anti-oxidants returned near to control values after 28 days.
Impact of Plant- Based Diet in Prevention of Non-Communicable Diseases
Authors: Behisht Nujba , R. Navaneetha
Published: July 2022

Abstract: Plant-Based diet includes fruits , vegetables, nuts, seeds, oils, whole grains, legumes, and beans. A vegan diet excludes all animal products. A plant-based diet provides necessary proteins, fats, carbohydrates, vitamins , minerals as well as abundant fibre and phytonutrients required for optimal health, Essential nutrients present in plant diet helps to alleviate inflammation in our bodies. The covid pandemic has prompted many people to switch to a more organic, plant-based diet that includes nutraceuticals or supplements. This trend is gaining popularity globally. A literature search of plant based protein, food sources, nutritional composition and health benefits, effect on cardiovascular risk, insulin resistance, benefits of plant protein intake vs animal protein in the prevention and management of cancer , effect of vegan diet on coronary heart disease was carried out. As per the literature, studies were conducted on functional and bioactive properties of soy protein in terms of reducing disorder risk, modulating inflammation and their systemic effects. Dual X-ray Absorptiometry assessed body composition, Homeostasis Model Assessment (HOMA-IR) assessed insulin resistance, and a linear regression model was used to find out effect of plant based diets on weight loss. Using a data from Nurses Health Study 2, substituting 5% energy intake from vegetarian protein for animal protein was associated with 23% lower risk of type-2 diabetes mellitus. The study involved a supervised resistance educational programme was conducted twice a week for 12 weeks to compare a vegan diet with omnivores diet. This review article gives an overview of plant based diet and emphasises the benefits of a plant based diet, and its impact on the body and mind
KRUCIAL: A Blessing in Disguise
Authors: Das Sumit Kumar
Published: July 2022

Abstract: This is a website for searching availability of any stationary product in the nearby stationary stores of the user, now including the online pharmacy feature and then the user can place the order in any of those stores. The user will enter the product name required. After searching for the availability of that product in the nearby store, the result will be shown (including a description of the product, price of the product, etc). Then the user can compare the price and quality of the product. After that, the user can choose a store from where they want to order the required product. The users can directly explore the website and can continue shopping. And once the order gets confirmed from the store the user will receive confirmation details. Once the order gets delivered the user will receive a feedback form about theexperience of shopping with our website and also the delivery time, behavior of that delivery person. The user can also rate and write reviews on our website about the store they have placed their order.
Identification of Teacher Interaction in Online Class
Authors: B S Mrs. Nanda
Published: July 2022

Abstract: The system investigate teacher’s instructional activities from live audio of online class. The system is trained using python to identify the occurrences of eight key instructional activities from teacher audio. The system was able to identify eight key instructional activities using speech recognition techniques with an eye towards providing automatic feedback to teachers. One advancement in the field of automation is the Automated Attendance system replacing the old and traditional attendance marking. This system is based on the face detection and face recognition algorithms. The concept of this paper is to provide real time teacher attendance to the faculty’s data base. Automatically detects the teacher face using the web camera and detect the facial part using Haar cascade algorithm and the image undergoes the various techniques and will compare with reference image, Later the attendance of the teacher is updated .Thus with the help of this system time will be saved and it is so convenient to record the attendance at any time throughout the day.
Standalone Chatbot Application in Python
Authors: V C Dr. Mahavishnu , R Roopakumar , S G Vikhas , A Abivishvas
Published: July 2022

Abstract: A chatbot is an artificial intelligence (AI) software that can simulate a conversation (or a chat) with a user in natural language through messaging applications, websites, mobile apps or through the telephone. This software is used to do duties such as replying swiftly to users, informing them, assisting with product purchases, and delivering better customer support. Business groups are increasingly using chatbots because they may minimize customer support costs and handle several consumers at once. However, in order to complete various jobs, chatbots must be as efficient as possible. In this project, we provide the architecture of a chatbot, which provides a human like and accurate response for any questions raised by users using Natural Language ToolKit(NLTK) and PyTorch with python language.
Design and Analysis of Prestressed Shell Roof Structures
Authors: Satyannavar Niranjan. B.
Published: July 2022

Abstract: In this paper, pre-stressed precast substantial Shell roof structures is proposed as an option in contrast to customary roof structures. plan of shell roof top utilizing supported concrete is extremely challenging. To oppose the high strain in base harmony, the substantial support should be pre-stressed. Here, the displaying of various setups of prestressed precast substantial shell roof structures is finished utilizing Staadpro v8i programming by changing its mathematical boundaries, for example, shapes, slant, length and dispersing of the support and investigation and streamlining is done to find the best and best prestressed precast substantial Shell roof structures designs fit to different circumstances feasible way of life implies reconsidering our approaches to everyday life, how we purchase and how we sort out our day to day existence. It is likewise about modifying how we mingle, trade, share, instruct and construct personalities. It implies changing our social orders and living in agreement with our common habitat. As residents, at home and at work, a large number of our decisions - on energy use, transport, food, waste, correspondence and fortitude - contribute towards building economical ways of life In India, customary practices that are feasible and climate well-disposed keep on being a piece of individuals' lives. India has a past filled with low carbon impression and way of life. These should be energized, rather than supplanted by more current yet unreasonable practices and advancements. This is likewise relevant to other non-industrial nations where there is a developing interest in elective models of advancement, and on restoring green cognizance drawing on conventional societies. Keywords: Precast Concrete, RCC cylindrical shell roof structures, STAAD PRO V8i, Prestressed precast shell structures
Indexing of Factors Affecting Time and Cost Overrun in Construction Projects
Authors: Shakya Kumar Gourav , Gupta Er. Himmi
Published: July 2022

Abstract: In a construction project, time overrun occurs when the work specified in the contract is not executed within the specified time frame and when the entire project cost exceeds for whatever causes, this is referred to as cost overrun. This study aim to analyze these factors that cause above delays in construction projects. A total 47 such factors were identified and classified into 8 segments, which are then indexing by using the method Relative Importance Index (RII).
Centro de Investigación y Acción Psicosocial Comunitaria: un escenario para la construcción de paz
Authors: Vargas Hurtado Gloria Isabel , Vargas Paredes Shyrley Rocío , Rebolledo Cortés Henry Steven , Benavides V. Oscar Andrés , Villarreal Morales Heliana Magaly , Alvarado Rozo Omar Alberto , Sánchez Falla Carolina , Jaimes Catherine Johana , Campos Ramírez Nelly , Rivera Quintero Katherine
Published: July 2022

Presentamos un libro compilado por tres grandes capítulos: el primero presenta los avances y reflexiones de los investigadores del centro en torno al campo de la educación, perspectivas y tendencias; el segundo, denominado Proyecciones para el Desarrollo Humano, muestra algunas reflexiones para la transformación de la sociedad, las poblaciones más necesitadas con las que trabaja el Centro de Investigación y propuestas para el desarrollo social. Por último, como un eje fundamental del Centro de Investigación, se encuentra el capítulo tres, Investigación y acción en la transformación de la región, que muestra las reflexiones en torno al quehacer investigativo en Colombia, su región y su impacto en escenarios educativos y organizativos de las comunidades. El conocimiento producto de esta compilación de experiencias y reflexiones investigativas representa un importante material para los lectores en tanto posibilita fortalecer el conocimiento y propuestas aplicativas en el campo educativo, psicológico social comunitario e investigativo. Consideramos que los capítulos presentados serán referentes para programas, proyectos e investigadores en estos campos que sumen y líen esfuerzos. Podrá fungir como texto de consulta metodológica en tanto expone estrategias de los grupos e investigadores del centro de investigación; de esta manera, circula como una guía de formación para investigadores, estudiantes de niveles de pregrado o posgrado, especialización, maestría y doctorados en educación, pedagogía, psicología, formación docente y formación investigativa.
Educación, perspectivas y tendencias
Authors: Vargas Hurtado Gloria Isabel , Vargas Paredes Shyrley Rocío , Villarreal Morales Heliana Magally , Sánchez Falla Carolina , Ortegón Pava Milton Fernando , Marín Idárraga Diego Alberto , Buenaventura Monsalve Jaime Alberto , Carrero Moreno Andrea Marcela , Sánchez Barrera María Elva , Pérez Rivera Martha Lucía , Mayorga Ortegón Angela Ivethe , Sánchez Liliana , Hernández Cruz Victoria Eugenia
Published: July 2022

El presente capítulo de reflexión es el resultado de la investigación desarrollada en 10 instituciones educativas del departamento del Tolima, proyecto ejecutado entre la Secretaría de Educación Departamental y la Universidad Nacional Abierta y a Distancia (UNAD). Se visibiliza e interpreta el impacto de un proceso de articulación coherente con el contexto educativo actual. Los resultados preceden a un análisis y diagnóstico situacional; la identificación de variables endógenas y exógenas del aula permiten mejorar la calidad de la educación a partir del for-talecimiento del proyecto educativo institucional (PEI), el plan de mejoramiento institucional (PMI) y el plan operativo institucional (POI), desde una la mirada holística del sistema educativo en Colombia, su interacción con los resultados de las pruebas censales de la educación básica secundaria y las pruebas saber realizadas por el Icfes en el departamento del Tolima en el año 2014. Igualmente se presentan conjeturas que permitirán que la comunidad académica establezca un comparativo relacional.
Infected by theory - The Making of theoretical films
Authors: Evi Jägle
Published: July 2022

To connect or spread this to an artistic research would be a table for translating theoretical texts from Deleuze into a kinematographic vision and the background of how this can be done and why it is necessary. So it connects also with difference and repetition and its spreading power.
For example:
So art has the impact to transform things we can not say with theory and also links to the necessity to have an artistic theory. Spreading ideas and following the card of this ideas.
A deleuzian diagram for Foucault
Authors: Evi Jägle
Published: July 2022

On the basis of the diagram that Deleuze made about Foucault himself to draw a path through his work, the lines are traced that bring it into contact with the cinematic thinking from Deleuze's time-image and movement-image and which kind of junctions between the works were found. A kinematographic view on Foucault projects him onto a filmic expression. For Deleuze, Foucault’s diagram is an exterior that gives his own thinking a layered structure, a layered formation. The layers form deposits and the reference to the outside of the diagram as a cinematographic cutting apparatus calls the visibilities and sayings into question again by assembling them together in such a way that an alogical cut is created. The creation of which must be sought. The distance in the power relations, which is reflected in the visible and the sayable, was able to experience a view with a transition to the film books that attaches a constitutive character to the interval and does not have to ignore it. A video expression will give the diagram of Foucault a visible character and uses Foucaults work as instruction or stage directions for how the sayable and seeable are connected.
Protein Structure Prediction with Expectation Reflection
Authors: Cresswell-Clay Evan , Hoang Danh-Tai , McKenna Joe , Zhang Eric , Periwal Vipul , Yang Chris
Published: July 2022

Sequence covariation in multiple sequence alignments of homologous
proteins has been used extensively to obtain insights into protein
structure. However, global statistical inference is required in order to
ascertain direct relationships between amino acid positions in these
sequences that are not simply secondary correlations induced by
interactions with a third residue. Methods for statistical inference of
such covariation have been developed to exploit the growing availability
of sequence data. These hints about the folded protein structure provide
critical a priori information for more detailed 3D predictions by
neural networks. We present a novel method for protein structure
inference using an iterative parameter-free model estimator which uses
the formalism of statistical physics. With no tunable learning rate, our
method scales to large system sizes while providing improved performance
in the regime of small sample sizes. We apply this method to 40974 PDB
structures and compare its performance to that of other methods. Our
method outperforms existing methods for 76% of analysed proteins.
Fractions with too much friction; Genome-wide SNPs in the spiny lobster Panulirus homarus reveal a hybrid origin for the subspecies
Authors: Farhadi Ahmad , Jeffs A , Lavery Shane
Published: July 2022

Evolutionary divergence and speciation often occur at a slower rate in
the marine realm due to the higher potential for long-distance
reproductive interaction through larval dispersal. One common
evolutionary pattern in the Indo-Pacific, is divergence of populations
and species at the peripheries of widely-distributed organisms. However,
the evolutionary and demographic histories of such divergence are yet to
be well understood. Here we address these issues by coupling genome-wide
SNP data with mitochondrial DNA sequences to test the patterns of
genetic divergence and possible secondary contact among geographically
distant populations of the highly valuable spiny lobster Panulirus
homarus species complex, distributed widely through the Indo-Pacific,
from South Africa to the Marquesas Islands. After stringent filtering,
2020 SNPs were used for population genetic and demographic analyses,
revealing strong regional structure (FST = 0.148, P<0001),
superficially in accordance with previous analyses. However, detailed
demographic analyses supported a much more complex evolutionary history
of these populations, including a hybrid origin of a North-West Indian
Ocean (NWIO) population, which has previously been discriminated
morphologically, but not genetically. The best-supported demographic
models suggested that the current genetic relationships among
populations were due to a complex series of past divergences followed by
asymmetric migration in more recent times. Overall, this study suggests
that alternating periods of marine divergence and gene flow have driven
the current genetic patterns observed in this lobster and may help
explain the observed wider patterns of marine species diversity in the
Indo-Pacific.
Sexual interference revealed by joint study of male and female pollination success in chestnut
Authors: LARUE Clément , Klein Etienne , Petit Rémy
Published: July 2022

Pollination is a key step of plant reproduction, allowing individual
plants to produce offspring as father, mother or both. However, few
studies exist that consider together male and female pollination
success. This implies studying both mating system, through paternity
analyses, and seed set, by measuring the percentage of flowers giving a
seed. Studying these two processes together is needed as they are not
independent: gaining fitness advantage through one sex can incur fitness
costs through the other due to various tradeoffs including direct sexual
interference. Hence, we developed the first spatially explicit
mixed-mating model integrating these two interactive processes, by
coupling a mating model with a fruit set model, therefore jointly
exploring pollen export and import. We used as model an
insect-pollinated tree species, chestnut. We carried out a paternity
analysis based on nearly exhaustive sampling of potential pollen donors
in an intensively studied plot of 273 trees belonging to three
interfertile chestnut species and including both male-fertile and
male-sterile individuals. We collected a large dataset of 1924 mating
events. We further performed fruit set measurements for 216 trees. Our
process-based model predicts fruit set with great accuracy, but only if
we account for self-pollen interference and associated ovule
discounting, a form of sexual interference. This model represents an
important step forward for fundamental pollination studies aiming at
comprehensively exploring pollen emission, transport and reception in a
single study, thus clarifying the consequences of pollination on male
and female fitness.
Three Genome-scale Approaches Support that Lungfish is the Closest Living Relative of Land Vertebrate, but not Coelacanth
Authors: Shan Yunfeng
Published: July 2022

The origin of tetrapod has been one of intense debating open questions
for decades between coelacanth(Latimeria chalumnae) and lungfish
(Protopterus annectens). For resolving this incongruence in phylogenies,
a genome-wide data mining approach is used to retrieve 43 shared genes
of seven taxa from GenBank and further 1001 orthologous genes of ten
taxa from the Ensembl and NCBI. We used the maximum gene-support tree
approach and the majority-rule branch approach to analyze 43 nuclear
genes encoding amino acid residues and compared these results to those
inferred with the concatenation approach. Our results successfully
provide strong evidence in favor of the lungfish-tetrapod hypothesis,
but rejecting the coelacanth-tetrapod hypothesis based on significantly
fewer gene supports and lower taxon jackknife probabilities for the
coelacanth-tetrapod clade than the lungfish-tetrapod one with the
maximum gene-support tree approach and the jackknife method for taxon
subsampling. When more and more genomic data become available in recent
years, sequence data of 1001 shared genes was mined. We used the maximum
gene-support approach with this larger dataset successfully to infer
that lungfish is the closest relative of land vertebrates with a
significant difference at p < 0.01 (Chi-Square test) in gene
support values between a maximum gene-support tree and the second most
gene support tree with ML methods. The second most support to the
maximum (SM ratio), a relative value, is a better support index than a
single absolute value of support to show the insight of the phylogenetic
support. Our results also show increasing the number of shared genes is
much more effective than increasing the number of taxa.
ANTIARRHYTHMIC CALCIUM CHANNEL BLOCKER VERAPAMIL INHIBITS TREK CURRENTS IN SYMPATHETIC NEURONS.
Authors: Herrera-Pérez Salvador , Rueda-Ruzafa Lola , Campos-Rios Ana , Fernandez-Fernandez Diego , Lamas J. Antonio
Published: July 2022

Background and Purpose: Verapamil, a drug widely used in certain cardiac
pathologies, exert its therapeutic effect mainly through the blockade of
cardiac L-type calcium channels. However, we also know that both
voltage-dependent and certain potassium channels are blocked by
verapamil. Because sympathetic neurons of the superior cervical ganglion
(SCG) are known to express a good variety of potassium currents, and to
finely tune cardiac activity, we speculated that the effect of verapamil
on these SCG potassium channels could explain part of the therapeutic
action of this drug. To address this question, we decided to study, the
effects of verapamil on three different potassium currents observed in
SCG neurons: delayed rectifier, A-type and TREK (a subfamily of K2P
channels) currents. We also investigated the effect of verapamil on the
electrical behavior of sympathetic SCG neurons. Experimental Approach:
We employed the Patch-Clamp technique to mouse SCG neurons in culture.
Key Results: We found that verapamil depolarizes of the resting membrane
potential of SCG neurons. Moreover, we demonstrated that this drug also
inhibits A-type potassium currents. Finally, and most importantly, we
revealed that the current driven through TREK channels is also inhibited
in the presence of verapamil. Conclusion and Implications: We have shown
that verapamil causes a clear alteration of excitability in sympathetic
cells. This fact undoubtedly leads to an alteration of the
sympathetic-parasympathetic balance which may affect cardiac function.
Therefore, we propose that these possible peripheral alterations in the
autonomic system should be taken into consideration in the prescription
of this drug.
Interspecies normalization of dose response relationship for adeno-associated virus-mediated hemophilia gene therapy -- application to first-in-human dose prediction
Authors: Zou Peng
Published: July 2022

Establishing dose response relationships in targeted patients is
foundational in the development of therapeutic drugs including gene
therapy products. Enlightened by interspecies normalization of plasma
drug concentration-time curves using Dedrick plot, the author of this
manuscript first demonstrated the feasibility of normalizing
dose-response relationship of adeno-associated virus (AAV)-mediated
hemophilia gene therapy products in multiple species to a
species-invariant scale. Preclinical dose-response relationships of
eight AAV vectors were normalized using an exponent of 0.25 and applied
to first-in-human (FIH) dose prediction. The performance of this
dose-response normalization approach for FIH dose prediction was
compared to that of direct body weight-based dose conversion and
allometric scaling approaches. The study results suggested that in
addition to hemophilia dogs and non-human primates, inclusion of larger
animal models (e.g., swine and cattle) in preclinical dose-finding
studies of AAV vectors might improve the performance of interspecies
dose-response normalization approach. Furthermore, it was found that AAV
capsid-specific T cell responses in hemophilia patients might cause
underprediction of FIH dose while novel bioengineered capsids with a
high transduction efficiency specifically in human hepatocytes might
cause overprediction of FIH dose. These factors should be considered
when dose-response is extrapolated from preclinical species to patients.
Uso de la investigación narrativa en la investigación en enfermería familiar
Authors: Peña-Pita Amalia Priscila , Salamanca-Ramos Emilce , Cifuentes-Tinjaca Cristian David
Published: July 2022

La investigación narrativa en el campo de la enfermería se ha convertido en una herramienta fundamental para identificar las subjetividades del cuidado de la salud. A través de ella se pueden transformar las prácticas de enfermería y facilitar una mejor comprensión de la existencia, basada en el conocimiento de la realidad sentida e interpretada por las personas que requieren el cuidado. A lo largo del texto se encontrarán diferentes citaciones y experiencias que permiten mostrar la importancia de orientar las futuras investigaciones con enfoque cualitativo-narrativo, lo que, seguramente, ayudará a humanizar el cuidado de la salud en la región.
Gramophone records of the singer Mijat Mijatovic: From (re)construction of discography to the study of recorded music
Authors: Lajic-Mihajlovic Danka , Pokrajac David , Spasojevic Sasa
Published: July 2022

The study of gramophone records is important when acquainting oneself with Mijat Mijatovic (1887-1937), who strongly impacted so-called folk music in the Kingdom of Serbs, Croats and Slovenes / Yugoslavia, considering the importance of the records he released during his career. His opus of commercial recordings is the largest of the interwar period in the area and, therefore, it is highly indicative when considering the correlation between the early music industry and ?local? culture as a glocal topic. In this study we present numerous sources and a complex critical analysis that resulted in Mijatovic?s discography. Special attention has been paid to record companies, the chronology of recordings, the repertoire and collaborating musicians, thus mapping the potential of discography for the study of recorded music and cultural history.
Two faces of mystification: the representation of the holocaust in Arnold Schoenberg's a survivor from Warsaw and Steve Reich's different trains
Authors: Mevorah Vera
Published: July 2022

The paper discusses the approaches of different media to Holocaust (re)presentation, with special reference to art music in the 20th century. Following the classification proposed by Michael Rothberg on two possible perspectives for representing the Holocaust: realistic and anti-realist (2000), we analyse two compositions: Arnold Schoenberg?s A Survivor From Warsaw (1947) and Steve Reich?s Different Trains (1988). The aim of the paper is to point out how artistic music reflects and participates in the dominant historical and contemporary discourses of Holocaust representation, especially the discourses of ?heroism? and ?non-representability?.
Applying the concept of musical social entrainment in researching tambura practice in Serbia
Authors: Bastic Julijana
Published: July 2022

Entrainment in music refers to the interaction and synchronization of two or
more rhythmic processes. The first part of this paper presents entrainment
the?ory in ethnomusicology as a methodology for interdisciplinary research
into musical, social, and cultural phenomena. The second part of the paper
concerns the application of the concept of musical social entrainment in the
example of tambura practice. Because tambura players display mutual
entrainment through various behaviors during playing and social interaction,
applying entrainment theory entails an analytical segmentation of the social
and musical spheres in a specific musical performance.
Acute disseminated encephalomyelitis in children and adolescents - 20-year single-center experience in Serbia
Authors: Ostojic Slavica , Kravljanac Ruzica , Kovacevic Gordana , Vucetic-Tadic Biljana , Gazikalovic Slobodan , Sarajlija Adrijan
Published: July 2022

Introduction/Objective. Acute disseminated encephalomyelitis (ADEM) is the most common demyelinating disease of the central nervous system in pediatric patients. We aimed to evaluate the clinical profile of children with ADEM and to discern prognostic factors for disease outcome. Methods. A 20-year retrospective?prospective study was conducted in a cohort with the diagnosis of ADEM. Results. The study included 36 patients, with range of follow-up period of 6?120 months (median of 26 months). Prior infection was reported in 72.2% of the patients. In the clinical presentation of the disease, motor deficit was most common (81.1%), followed by ataxia (77.8%). More than a third of patients had back and limb pain or abdominal visceral pain, which highly correlated with MRI findings of myelitis. Abnormal brain CT findings were evident in 22.2% of the patients, and this was associated with higher Expanded Disability Status Scale (EDSS) and quicker progression of the disease. Median EDSS was 0 at the most recent follow-up visit, in all the patients. EDSS 0?2.5 was verified in 29 (80.6%) of the patients, while three (8.3%) patients scored 7?9.5 at the last visit. Two patients had a lethal outcome. Conclusions. ADEM is a serious disease in pediatric patients, but with a good prognosis, which is illustrated by the fact that 80.6% of our patients had a complete or almost complete recovery.
Different angiogenic response and bone regeneration following the use of various types of collagen membranes - in vivo histomorphometric study in rabbit calvarial critical-size defects
Authors: Stepic-Hajdarpasic Jelena , Brkovic Bozidar , Dragovic Miroslav , Pejovic Marko , Sopta Jelena , Kuzmanovic-Pficer Jovana , Colic Snjezana
Published: July 2022

Introduction/Objective. Success of guided bone regeneration depends on the size and morphology of defect, characteristics of barrier membranes and adequate angiogenesis. The aim of the study was to reveal impact of three different collagen membranes on angiogenesis and bone production in critical-size defects. Methods. Defects were created in rabbit calvarias, filled with bovine bone graft and randomly covered with one of three investigated collagen membranes (Biogide ? BG, Heart ? PC, Mucograft ? MG) or left without a membrane for the control group (C). After two and four weeks of healing, a total of 10 animals were sacrificed for histological and histomorphometric analysis of angiogenesis, bone regeneration, and inflammatory response. Results. In the early healing phase, the highest values of trabecular thickness and trabecular area were recorded with PC and BG membranes, respectively. After four weeks, significantly improved bone healing was noted in the MG group, as well as significantly pronounced inflammation. Initially, vessel density was significantly higher in the C group compared to all three membranes. After four weeks, significantly better results were observed in the MG compared to the other groups, BG compared to the rest of groups, and between PC and C groups. Conclusion. The use of collagen membranes significantly affects angiogenesis, reducing it in the early and enhancing it at the later healing phase. All three tested membranes in combination with bone graft significantly improved the amount of regenerated bone. Among the investigated groups, MG favored more pronounced angiogenic, osteogenic, and inflammatory response in the observation period of four weeks.
Insulin response to oral glucose and cardiometabolic disease: A Mendelian randomization study to assess potential causality
Authors: Nguyen Anthony , Khafagy Rana , Meerasa Ameena , Roshandel Delnaz , Paterson Andrew D. , Dash Satya
Published: July 2022

  

Mendelian randomization (MR) suggests post-prandial hyperinsulinemia (unadjusted for plasma glucose) increases body mass index (BMI) but its impact on cardiometabolic disease (CMD), a leading cause for mortality and morbidity in people with obesity is not established. Fat distribution i.e. increased centripetal and/or reduced femoro-gluteal adiposity is causally associated with and better predicts CMD than BMI. We therefore undertook bi-directional MR to assess the effect of corrected insulin response (CIR, insulin 30 minutes after a glucose challenge adjusted for plasma glucose) on BMI, waist-to-hip ratio (WHR), leg fat, type 2 diabetes (T2D), triglyceride (TG), high-density lipoprotein (HDL), liver fat, hypertension and CAD in people of European descent.

Inverse variance weighted MR suggests a potential causal association between increased CIR and increased BMI (b= 0.048±0.02, p=0.03), increased leg fat (b=0.029±0.012, p=0.01), reduced T2D (b=-0.73±0.15, p=6x10-7, OR 0.48 (0.36-0.64), reduced TG (b=-0.07±0.02, p=0.003) and increased HDL (b=0.04±0.01, p=0.006) with some evidence of horizontal pleiotropy. CIR had neutral effects on WHR (b=0.009±0.02, p=0.69), liver fat (b=-0.08±0.04, p=0.06), hypertension (b=-0.001±0.004, p=0.7, odds ratio (OR) (95% confidence interval (CI)) OR 1.00 (0.99-1.01) and coronary artery disease (b=-0.002±0.002, p=0.48, OR 0.99 (0.81-1.21). T2D decreased CIR (b-0.22±0.04, p=1.3x10-7), with no evidence that BMI, TG, HDL, liver fat, hypertension and CAD modulate CIR. 

In conclusion, we did not find evidence that increased CIR increases CMD. It might increase BMI with favorable fat distribution, reduce T2D and improve lipids.
Comparative Efficacy and Safety of Monoclonal Antibodies and Janus Kinase Inhibitors in Moderate-to-severe Atopic Dermatitis: A Systematic Review and Meta-analysis
Authors: Sedeh Farnam B. , Henning Mattias A.S. , Jemec Gregor  B.E. , Ibler Kristina S.
Published: July 2022

The aim of this study was to compare the efficacies of systemic treatments with dupilumab, tralokinumab and Janus kinase inhibitors for moderate-to-severe atopic dermatitis. A systematic review following Preferred Reporting Items for Systemic Reviews and Meta-Analyses (PRISMA) guidelines was performed using Medline, EMBASE and Cochrane library. All randomized controlled trials investigating the efficacy of systemic treatments for moderate-to-severe atopic dermatitis in adults were included. Primary outcomes were the proportion of patients with atopic dermatitis achieving 50%, 75%, and 90% improvement in Eczema Area and Severity Index (EASI) score after dupilumab, tralokinumab or Janus kinase inhibitors. Nineteen studies totalling 6,444 patients were included. In monotherapy studies, upadacitinib 30 mg once daily had the numerically highest efficacy regarding EASI-50, EASI-75 and EASI-90. In combination therapy studies with topical corticosteroids, dupilumab 300 mg once every other week had highest efficacy regarding EASI-50, and abrocitinib 200 mg once daily had the highest score regarding EASI-75 and EASI-90. Analysis provided evidence that dupilumab, tralokinumab and Janus kinase inhibitors all had an acceptable efficacy profile and resulted in clinically relevant improvements in EASI score. Furthermore, upadacitinib and abrocitinib seem to have great potential to treat patients with atopic dermatitis. However, further studies are needed to determine the long-term efficacy of Janus kinase inhibitors in adults with moderate-to-severe atopic dermatitis.
Discovery of Psoriatic Arthritis in Psoriasis Patients for Early Rheumatological Referral (DAPPER) Study: A Prospective Observational Cohort
Authors: Van Hal Tamara W. , Mulder Michelle L.M. , Wenink Mark H. , Pasch Marcel C. , Van den Hoogen Frank H.J. , Van den Reek Juul M.P.A. , De Jong Elke M.G.J.
Published: July 2022

Patients with psoriasis are at risk of developing psoriatic arthritis, which can lead to irreversible joint damage. However, a proportion of patients with psoriasis and concomitant psoriatic arthritis remain undiscovered in practice. The aims of this study were: to prospectively determine prevalence, characteristics, and disease burden of psoriatic arthritis in a psoriasis population; and to determine the prevalence and characteristics of patients with active psoriatic arthritis, who were not under rheumatological care. Patients with psoriasis were screened by a rheumatologist at the dermatology outpatient clinic for psoriatic arthritis. Patients with suspected active psoriatic arthritis who were not seeing a rheumatologist were referred to a rheumatologist for confirmation. The total prevalence of psoriatic arthritis in this observational, prospective cohort (n = 303) was 24%. Patients with psoriasis with concomitant psoriatic arthritis had longer duration of skin disease and more often a treatment history with systemic therapies. In this academic, specialized, setting, 2.3% of patients (n = 7), were not receiving rheumatological care despite having active psoriatic arthritis. These patients were characterized by a combination of low (perceived) disease burden and low yield of screening questionnaires, making it difficult for dermatologists to discover psoriatic arthritis in these patients. Thus, screening for more subtle active arthritis in patients with psoriasis in a dermatology setting could be improved.
PENGARUH REMUNERASI DAN MOTIVASI KERJA TERHADAP KINERJA KARYAWAN (STUDI KASUS PADA KANTOR PENGAWASAN DAN PELAYANAN BEA DAN CUKAI SURAKARTA)
Authors: Bima Srigusti
Published: July 2022

Penelitian ini bertujuan untuk menganalisis: 1) pengaruh remunerasi terhadap kinerja karyawan., 2) pengaruh motivasi kerja terhadap kinerja karyawan. Data diperoleh dari 86 responden yang merupakan pegawai BEA dancukai Surakarta. Metode analisis yang digunakan adalah regresi linier berganda. Hasil pengujian instrument penelitian menyimpulkan bahwa semua butir pertanyaan tiap variabel valid dan reliabel. Uji asumsi klasik menunjukkan bahwa data berdistribusi normal, linier, tidak terjadi multikolinieritas dan tidak terjadi heteroskedastisitas. Hasil dari penelitian ini menunjukkan bahwa: 1) remunerasi berpengaruh positif dan signifikan terhadap kinerja karyawan, 2) motivasi kerja berpengaruh positif dan signifikan terhadap kinerja karyawan
PENGARUH MEDIA SOSIAL ONLINE DAN MEDIA PROMOSI OFFLINE TERHADAP PEMILIHAN MEREK PRODUK SKINCARE DAN KLINIK KECANTIKAN
Authors: Kussudyarsana Kussudyarsana , Rejeki Lestari
Published: July 2022

This study aims to determine the effect of online social media and offline promotional media on the selection of skincare product brands and beauty clinics. The data used in this study were primary data and sample selection in this study uses a non-probability sampling approach with purposive sampling technique. The sample used was 300 respondents. Data analysis methods in this study include validity test, reliability test, classic assumption test, multiple linear regression test, hypothesis test. The results of this study indicate that (1) online social media has a significant effect on the selection of skincare product brands (2) online social media has a significant effect on beauty clinic selection (3) offline promotional media has a significant effect on skincare product brand selection (4) offline promotional media influences significant to the selection of beauty clinics (5) online social media is more effective than offline promotion media on the selection of skincare products and beauty clinics.
Dampak Motivasi Kerja, Kepuasan dan Kinerja Polisi Wanita
Authors: Wardhani Diana Pramudya , Hartono Sri
Published: July 2022

The organization's ability to successfully achieve its goals is supported by internal and external factors of the organization. Employee performance is generally driven by security, social, self-actualization rewards. The female police force has grown rapidly. However, almost no research has examined the motivation of policewomen to join law enforcement and performance. The purpose of this study was to determine and analyze the impact of work motivation on female police by mediating job satisfaction of the police, totaling 61 people at the Ponorogo Police. Data collection in this study was carried out through a survey approach through quantitative descriptive research by distributing questionnaires to 61 respondents. The data analysis method used is path analysis. The results showed that work motivation has an influence on job satisfaction. The second result, work motivation has an influence on performance and the third result of job satisfaction has an influence on performance. The overall findings for this study suggest that motivation theory is an explanatory framework where organizational identification impacts job satisfaction. Moreover, it is inversely related to satisfaction not shown to play a mediating role in the relationship between motivation and performance of female police officers