bluuebunny/crossref_metadata_2025 huggingface dataset:
Morphomolecular and pathological study of Scaphanocephalus sp. in new host Siganus argenteus in the Arabian Gulf
Authors: Mubark Al-Salem AA , Baghdadi HB , Mahmoud MA , Ibrahim M , Bayoumy EM
Published: March 2021

In this study,Scaphanocephalusparasite (Platyhelminthes: Heterophyidae) metacercariae were found inSiganus argenteus(forktail rabbitfish or streamlined spinefoot) in the Arabian Gulf of Jubail province, Saudi Arabia. The findings may constitute new host and locality records for this parasite. Based on the number of black spots containing parasite cysts per fish, our study indicated thatSiganus argenteushad high infection intensities of encysted metacercariae belonging to the genusScaphanocephalus. Of the 3500S. argenteusspecimens examined, 800 (22.9%) showed multiple black cysts over the entire body surface, including the membranous parts of fins, while none were seen on the internal organs. The prevalence of infection was highest in summer (June-August) (8.8%). The excysted metacercariae differed morphologically from previously identifiedScaphanocephalusspp. Molecular analysis of rDNA showed 100% identity with an unnamedScaphanocephalussp. reported in Caribbean fish. Therefore, our findings may indicate a new species of this previously rarely recorded fish parasite. The histopathological examination revealed that the encysted parasites were restricted to the dermal layer of the skin and surrounded by melanophores and a fibrous connective tissue capsule, with focal myositis and Zenker’s necrosis in the underlying muscle tissue. The characteristically ‘winged’ parasite was clearly observed within the cysts. The high prevalence ofScaphanocephalusinfection in siganid fish we detected requires further epidemiological study.
Case Report: Refractory Chronic Spontaneous Urticaria Treated With Omalizumab in an Adolescent With Crohn’s Disease
Authors: Barni Simona , Giovannini Mattia , Liccioli Giulia , Sarti Lucrezia , Gissi Anna , Lionetti Paolo , Mori Francesca
Published: March 2021

Chronic spontaneous urticaria (CSU) is a mast cell-driven disease that is often associated with autoimmune or autoinflammatory conditions. Omalizumab is recommended in the treatment of refractory CSU in patients over 12 years of age who do not respond to four standard doses of antihistamines. Omalizumab blocks the mast cells’ degranulation, thus interrupting the resulting inflammatory cascade driven by T-helper 2 (Th2) cytokines. The efficacy of omalizumab in controlling CSU and possible associated diseases has been studied in few patients so far. In particular, some case reports describe adults with CSU and concomitant inflammatory bowel diseases (IBD), such as Crohn’s disease (CD) or ulcerative colitis (UC). Although the treatment of CD with anti-tumor necrosis factors-α (TNF-α) seems to be effective in controlling CSU, no cases of the utility of omalizumab in patients with both conditions have been described so far. At the moment, there is no evidence that the pathogenetic mechanisms underlying CD are linked to the same pathways that are inhibited by omalizumab for the treatment of CSU. We present the first pediatric case of refractory CSU and CD in which omalizumab led to CSU remission, even if the follow-up period was limited. In conclusion, our experience shows how CSU could be associated with CD and successfully treated with the monoclonal anti-IgE antibody in a patient on immunosuppressive therapy. However, more data is needed from a larger population.
Connectivity and Functionality of the Globus Pallidus Externa Under Normal Conditions and Parkinson's Disease
Authors: Dong Jie , Hawes Sarah , Wu Junbing , Le Weidong , Cai Huaibin
Published: March 2021

The globus pallidus externa (GPe) functions as a central hub in the basal ganglia for processing motor and non-motor information through the creation of complex connections with the other basal ganglia nuclei and brain regions. Recently, with the adoption of sophisticated genetic tools, substantial advances have been made in understanding the distinct molecular, anatomical, electrophysiological, and functional properties of GPe neurons and non-neuronal cells. Impairments in dopamine transmission in the basal ganglia contribute to Parkinson's disease (PD), the most common movement disorder that severely affects the patients' life quality. Altered GPe neuron activity and synaptic connections have also been found in both PD patients and pre-clinical models. In this review, we will summarize the main findings on the composition, connectivity and functionality of different GPe cell populations and the potential GPe-related mechanisms of PD symptoms to better understand the cell type and circuit-specific roles of GPe in both normal and PD conditions.
Deep-Learning-Based Multivariate Pattern Analysis (dMVPA): A Tutorial and a Toolbox
Authors: Kuntzelman Karl M. , Williams Jacob M. , Lim Phui Cheng , Samal Ashok , Rao Prahalada K. , Johnson Matthew R.
Published: March 2021

In recent years, multivariate pattern analysis (MVPA) has been hugely beneficial for cognitive neuroscience by making new experiment designs possible and by increasing the inferential power of functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and other neuroimaging methodologies. In a similar time frame, “deep learning” (a term for the use of artificial neural networks with convolutional, recurrent, or similarly sophisticated architectures) has produced a parallel revolution in the field of machine learning and has been employed across a wide variety of applications. Traditional MVPA also uses a form of machine learning, but most commonly with much simpler techniques based on linear calculations; a number of studies have applied deep learning techniques to neuroimaging data, but we believe that those have barely scratched the surface of the potential deep learning holds for the field. In this paper, we provide a brief introduction to deep learning for those new to the technique, explore the logistical pros and cons of using deep learning to analyze neuroimaging data – which we term “deep MVPA,” or dMVPA – and introduce a new software toolbox (the “Deep Learning In Neuroimaging: Exploration, Analysis, Tools, and Education” package, DeLINEATE for short) intended to facilitate dMVPA for neuroscientists (and indeed, scientists more broadly) everywhere.
Word and Mystery: The Acoustics of Cultural Transmission During the Protestant Reformation
Authors: Boren Braxton
Published: March 2021

To a first-order approximation we can place most worship services on a continuum between clarity and mystery, depending on the setting and content of the service. This liturgical space can be thought of as a combination of the physical acoustics of the worship space and the qualities of the sound created during the worship service. A very clear acoustic channel emphasizes semantic content, especially speech intelligibility. An immersive, reverberant acoustic emphasizes mystery and music. One of the chief challenges in acoustical design is the fact that both clarity and immersion are subjectively preferred by audiences, yet these two goals are almost mutually exclusive of one another. The movement along this continuum in liturgical space can also be seen in the religious contexts for many of the worship spaces constructed in the West in the last two millennia. In the case of religious ceremony, a free field acoustic environment provides more clarity and precision in the spoken word received from God and given to the congregation. Yet a diffuse field environment provides an embodied, otherworldly sense of the supernatural: the mystery of the faith received which cannot merely be put into words. This tension is perceptible in many of the religious controversies in the West during this time period. This article examines the history of the spaces used by early Western Catholic Christians as well as those of the traditions—Lutheran and Calvinist—that left the Catholic faith during the 16th century Reformation. By considering the stated goals of these traditions alongside the architectural and liturgical innovations they created, it can be seen that emergent liturgical spaces mirror the assumptions of their respective traditions regarding the proper balance between semantic and aesthetic communication during the worship service. The Reformed faiths' emphasis on the power of the Word is reflected in the liturgical space of their services, while the Catholic faith gave greater priority to the role of Mystery, in their liturgical space as well as their explicit theology. Once constructed, these spaces also aid the cultural transmission of the sung or spoken liturgy of each tradition to future generations.
The Morphological Responses of Calendula officinalis L. “Radio” to the Foliar Application of Benzyladenine and Different Light Spectra
Authors: Frąszczak Barbara , Janowska Beata , Świerk Dariusz
Published: March 2021

Pot marigold is a valuable medicinal plant with great decorative value. Three combinations of light (white (W)—170 μmol m−2 s−1, white + blue (W+B)—230 μmol m−2 s−1, white + red (W+R)—230 μmol m−2 s−1) were used to analyse the influence of a diversified light spectrum on the morphological traits and flowering of Calendula officinalis L. “Radio”. The effect of foliar treatment of the plants with 6-benzyladenine (BA) at concentrations of 100, 150 and 200 mg dm−3 at all the light spectrum combinations was analysed. BA had negative influence on the earliness of florescence and delayed it even by more than 10 days. W+B light intensified the delay, whereas red light partly reduced it. The BA treatment had the greatest influence on the biometric traits of the plants at the initial period of their development. W+B light significantly inhibited the growth of the plants. A high share of red light in the spectrum positively affected the Fv/Fm value, the relative chlorophyll content and the percentage of dry matter in the plants. When the amount of blue or red light in the spectrum increased, it was possible to obtain specific biometric traits of Calendula without the BA treatment.
Anti-Inflammatory and Antioxidant Effects of Dietary Supplementation and Lifestyle Factors
Authors: Roberts Llion Arwyn , Suzuki Katsuhiko
Published: March 2021

Trends relating to specific diets and lifestyle factors like physical (in) activity have formed in recent times [...]
Circulating MicroRNAs in Blood and Other Body Fluids as Biomarkers for Diagnosis, Prognosis, and Therapy Response in Lung Cancer
Authors: Gayosso-Gómez Luis Vicente , Ortiz-Quintero Blanca
Published: March 2021

The identification of circulating microRNAs (miRNAs) in peripheral blood and other body fluids has led to considerable research interest in investigating their potential clinical application as non-invasive biomarkers of cancer, including lung cancer, the deadliest malignancy worldwide. Several studies have found that alterations in the levels of miRNAs in circulation are able to discriminate lung cancer patients from healthy individuals (diagnosis) and are associated with patient outcome (prognosis) and treatment response (prediction). Increasing evidence indicates that circulating miRNAs may function as mediators of cell-to-cell communication, affecting biological processes associated with tumor initiation and progression. This review is focused on the most recent studies that provide evidence of the potential value of circulating miRNAs in blood and other body fluids as non-invasive biomarkers of lung cancer in terms of diagnosis, prognosis, and response to treatment. The status of their potential clinical application in lung cancer is also discussed, and relevant clinical trials were sought and are described. Because of the relevance of their biological characteristics and potential value as biomarkers, this review provides an overview of the canonical biogenesis, release mechanisms, and biological role of miRNAs in lung cancer.
Incidence of Gender in the Digital Competence of Higher Education Teachers in Research Work: Analysis with Descriptive and Comparative Methods
Authors: Guillén-Gámez Francisco D. , Mayorga-Fernández María J. , Contreras-Rosado José A.
Published: March 2021

The purpose of this study is to analyse and compare the level of digital competence of higher education teaching staff in research work through the use of ICT resources. For this purpose, an ex post facto design was employed together with an instrument composed of 30 items classified into seven dimensions: digital skills, digital ethics, digital flow, anxiety towards ICT, quality of ICT resources, intention to use ICT, and ICT integration. The sample consisted of a total of 1704 higher education teachers from all over Spain. The results showed that, overall, there were no significant differences in the level of digital competence of teaching staff between the two genders. However, significant differences were found in the following dimensions: digital skills, digital ethics, ICT anxiety, quality of ICT resources, and intention to use ICT. These findings highlight the urgent need for university institutions to propose training plans to improve the digital competences of their teaching and research staff in those dimensions that have been found to be deficient.
Teachers’ Use of Descriptive Assessment in Primary School Mathematics Education in Iran
Authors: Van den Heuvel-Panhuizen Marja , Sangari Ali Akbar , Veldhuis Michiel
Published: March 2021

In many countries, assessment and curriculum reforms came into being in recent decades. In Iran, an important educational assessment reform took place called Descriptive Assessment (DA). In this reform, the focus of student assessment was moved from a more summative approach of providing grades and deciding about promotion to the next grade to a more formative approach of providing descriptive feedback aimed at improving student learning. In this study, we evaluated how seven fourth-grade mathematics teachers used the principles of DA. Data were collected by a questionnaire on assessment practices and beliefs, lesson observations, and interviews. Although the teachers varied in how they assess their students, in general their assessment practice is by and large in line with the DA guidelines. Nevertheless, in some respects we found differences. When assessing their students, the teachers essentially do not check the students’ strategies and when preparing the report cards, they still use final exams because they do not sufficiently trust the assessments methods suggested by DA. The guideline to use assessment results for adapting instruction is also not genuinely put into action. The article is concluded by discussing dilemmas the teachers may encounter when implementing DA.
Analysis and Design of Asymmetric Mid-Range Wireless Power Transfer System with Metamaterials
Authors: Zeng Yingqin , Lu Conghui , Rong Cancan , Tao Xiong , Liu Xiaobo , Liu Renzhe , Liu Minghai
Published: March 2021

In a wireless power transfer (WPT) system, the power transfer efficiency (PTE) decreases sharply with the increase in transfer distance. Metamaterials (MMs) have shown great potential to enhance PTE in mid-range WPT systems. In this paper, we propose two MM slabs of a 3 × 3 array to enhance the magnetic coupling. The MM unit cell was designed by using square spiral patterns on a thin printed circuit board (PCB). Moreover, the asymmetric four-coil WPT system was designed and built based on the practical application scenario of wireless charging for unmanned devices. The simulation and experimental results show that two MM slabs can enhance power transmission capability better than one MM slab. By optimizing the position and spacing of two MM slabs, the PTE was significantly improved at a mid-range distance. The measured PTEs of a system with two MM slabs can reach 72.05%, 64.33% and 49.63% at transfer distances of 80, 100 and 120 cm. When the transfer distance is 100 cm, the PTE of a system with MMs is 33.83% higher than that without MMs. Furthermore, the receiving and load coils were integrated, and the effect of coil offset on PTE was studied.
Understanding Why All Types of Motivation Are Necessary in Advanced Anaesthesiology Training Levels and How They Influence Job Satisfaction: Translation of the Self-Determination Theory to Healthcare
Authors: Moll-Khosrawi Parisa , Zimmermann Stefan , Zoellner Christian , Schulte-Uentrop Leonie
Published: March 2021

Studies applying the self-determination theory have shown that intrinsic motivation and autonomous regulation lead to job satisfaction and to better job performance. What has not been worked out clearly yet are the effects of extrinsic motivation and controlled regulation on affect, job performance and job satisfaction. However, it has been described that controlled regulation is often necessary for mundane tasks. In anaesthesiology, routine daily tasks can be perceived as mundane by those who have achieved a certain level of training (e.g., consultants). Therefore, it was hypothesised that consultants have high expressions of all motivational qualities. Furthermore, it was hypothesised that job satisfaction of anaesthesiologists is correlated with autonomous motivation. The hypotheses were tested in a cross-sectional study design within a group of anaesthesiologists. The study participants reported the same pattern throughout the motivational continuum. Consultants reported the highest levels of all motivational qualities, including controlled regulation, as well as the highest levels of job satisfaction. Junior residents reported high levels of amotivation and extrinsic regulation. The lowest levels of identified regulation and job satisfaction were reported by the group of attendings. Job satisfaction was positively correlated with intrinsic motivation and negatively correlated with amotivation. Therefore, our findings from the field of anaesthesiology show that the expressions of high levels of controlled regulation might be necessary for specialists to engage in mundane daily tasks. Intrinsic motivation and autonomous regulation are necessary for job satisfaction and the presence of controlled regulation and extrinsic behavioural regulation have no declining effects. Furthermore, the decrease of amotivation will lead to enhanced job satisfaction and the resulting consequences will be extensive. Junior residents need to be supported with the aim to enhance their feeling of autonomy and competence in order to decrease amotivation and to foster autonomous regulation and hence to increase job satisfaction and well-being. Further special focus should be on attendings to counteract their lacking identification with the job. Hereby, the provision of feedback and professional perspectives might foster the process of re-identification.
Pharmacological Evidence on Augmented Antiallodynia Following Systemic Co-Treatment with GlyT-1 and GlyT-2 Inhibitors in Rat Neuropathic Pain Model
Authors: Mohammadzadeh Amir , Lakatos Péter P. , Balogh Mihály , Zádor Ferenc , Karádi Dávid Árpád , Zádori Zoltán S. , Király Kornél , Galambos Anna Rita , Barsi Szilvia , Riba Pál , Benyhe Sándor , Köles László , Tábi Tamás , Szökő Éva , Harsing Laszlo G. , Al-Khrasani Mahmoud
Published: March 2021

The limited effect of current medications on neuropathic pain (NP) has initiated large efforts to develop effective treatments. Animal studies showed that glycine transporter (GlyT) inhibitors are promising analgesics in NP, though concerns regarding adverse effects were raised. We aimed to study NFPS and Org-25543, GlyT-1 and GlyT-2 inhibitors, respectively and their combination in rat mononeuropathic pain evoked by partial sciatic nerve ligation. Cerebrospinal fluid (CSF) glycine content was also determined by capillary electrophoresis. Subcutaneous (s.c.) 4 mg/kg NFPS or Org-25543 showed analgesia following acute administration (30–60 min). Small doses of each compound failed to produce antiallodynia up to 180 min after the acute administration. However, NFPS (1 mg/kg) produced antiallodynia after four days of treatment. Co-treatment with subanalgesic doses of NFPS (1 mg/kg) and Org-25543 (2 mg/kg) produced analgesia at 60 min and thereafter meanwhile increased significantly the CSF glycine content. This combination alleviated NP without affecting motor function. Test compounds failed to activate G-proteins in spinal cord. To the best of our knowledge for the first time we demonstrated augmented analgesia by combining GlyT-1 and 2 inhibitors. Increased CSF glycine content supports involvement of glycinergic system. Combining selective GlyT inhibitors or developing non-selective GlyT inhibitors might have therapeutic value in NP.
Current Advances in Comprehending Dynamics of Regenerating Axons and Axon–Glia Interactions after Peripheral Nerve Injury in Zebrafish
Authors: Gonzalez David , Allende Miguel L.
Published: March 2021

Following an injury, axons of both the central nervous system (CNS) and peripheral nervous system (PNS) degenerate through a coordinated and genetically conserved mechanism known as Wallerian degeneration (WD). Unlike central axons, severed peripheral axons have a higher capacity to regenerate and reinnervate their original targets, mainly because of the favorable environment that they inhabit and the presence of different cell types. Even though many aspects of regeneration in peripheral nerves have been studied, there is still a lack of understanding regarding the dynamics of axonal degeneration and regeneration, mostly due to the inherent limitations of most animal models. In this scenario, the use of zebrafish (Danio rerio) larvae combined with time-lapse microscopy currently offers a unique experimental opportunity to monitor the dynamics of the regenerative process in the PNS in vivo. This review summarizes the current knowledge and advances made in understanding the dynamics of the regenerative process of PNS axons. By using different tools available in zebrafish such as electroablation of the posterior lateral line nerve (pLLn), and laser-mediated transection of motor and sensory axons followed by time-lapse microscopy, researchers are beginning to unravel the complexity of the spatiotemporal interactions among different cell types during the regenerative process. Thus, understanding the cellular and molecular mechanisms underlying the degeneration and regeneration of peripheral nerves will open new avenues in the treatment of acute nerve trauma or chronic conditions such as neurodegenerative diseases.
Applications of Silver Nanoparticles in Dentistry: Advances and Technological Innovation
Authors: Fernandez Clara Couto , Sokolonski Ana Rita , Fonseca Maísa Santos , Stanisic Danijela , Araújo Danilo Barral , Azevedo Vasco , Portela Ricardo Dias , Tasic Ljubica
Published: March 2021

Silver nanoparticles (AgNPs) have been successfully applied in several areas due to their significant antimicrobial activity against several microorganisms. In dentistry, AgNP can be applied in disinfection, prophylaxis, and prevention of infections in the oral cavity. In this work, the use of silver nanoparticles in dentistry and associated technological innovations was analyzed. The scientific literature was searched using PubMed and Scopus databases with descriptors related to the use of silver nanoparticles in dentistry, resulting in 90 open-access articles. The search for patents was restricted to the A61K code (International Patent Classification), using the same descriptors, resulting in 206 patents. The results found were ordered by dental specialties and demonstrated the incorporation of AgNPs in different areas of dentistry. In this context, the search for patents reaffirmed the growth of this technology and the dominance of the USA pharmaceutical industry over AgNPs product development. It could be concluded that nanotechnology is a promising area in dentistry with several applications.
Sentinel Node Biopsy after Neoadjuvant Chemotherapy for Breast Cancer: Preliminary Experience with Clinically Node Negative Patients after Systemic Treatment
Authors: Sanchez Alejandro Martin , Terribile Daniela , Franco Antonio , Martullo Annamaria , Orlandi Armando , Magno Stefano , Di Leone Alba , Moschella Francesca , Natale Maria , D’Archi Sabatino , Scardina Lorenzo , Mason Elena J. , De Lauretis Flavia , Marazzi Fabio , Masetti Riccardo , Franceschini Gianluca
Published: March 2021

Sentinel lymph node biopsy (SLNB) following neoadjuvant treatment (NACT) has been questioned by many studies that reported heterogeneous identification (IR) and false negative rates (FNR). As a result, some patients receive axillary lymph node dissection (ALND) regardless of response to NACT, leading to a potential overtreatment. To better assess reliability and clinical significance of SLNB status on ycN0 patients, we retrospectively analyzed oncological outcomes of 399 patients treated between January 2016 and December 2019 that were either cN0-ycN0 (219 patients) or cN1/2-ycN0 (180 patients). The Endpoints of our study were to assess, furthermore than IR: oncological outcomes as Overall Survival (OS); Distant Disease Free Survival (DDFS); and Regional Disease Free Survival (RDFS) according to SLNB status. SLN identification rate was 96.8% (98.2% in patients cN0-ycN0 and 95.2% in patients cN+-ycN0). A median number of three lymph nodes were identified and removed. Among cN0-ycN0 patients, 149 (68%) were confirmed ypN0(sn), whereas regarding cN1/2-ycN0 cases 86 (47.8%) confirmed an effective downstaging to ypN0. Three year OS, DDFS and RDFS were significantly related to SLNB positivity. Our data seemed to confirm SLNB feasibility following NACT in ycN0 patients, furthermore reinforcing its predictive role in a short observation timing.
Influence of the Cadastral Value of the Urban Land and Neighborhood Characteristics on the Mean House Mortgage Appraisal
Authors: Guadalajara Natividad , López Miguel Ángel , Iftimi Adina , Usai Antonio
Published: March 2021

As house mortgage appraisal values have played a leading role in the 2007–2012 financial crisis, it is important to develop robust mass appraisal models that correctly estimate these values. The present paper intends to propose a methodology to examine the spatial distribution of house mortgage appraisal values. To do so, we analyzed the effect that these values, cadastral urban land values, characteristics of houses, and socioeconomic conditions and services in neighborhoods, have on house mortgage appraisal values in the 70 boroughs of Valencia (Spain). Econometric and spatial models were used, and variables were calculated as the mean and weighted values per boroughs. Our results showed that the hierarchy of cadastral values impacted mortgage appraisal values. Conversely, not all the boroughs-related variables influenced the mean mortgage values of houses, although some did anomalously. We conclude that the spatial error or autoregressive models provided very good fit results, which somewhat improved the ordinary least square model. Moreover, house mortgage appraisal values may be influenced by not only cadastral values but also by some district characteristics like mean family property size, vehicle age, distance from a metro station or from infant or primary education centers.
Biped Walking Based on Stiffness Optimization and Hierarchical Quadratic Programming
Authors: Shi Xuanyang , Gao Junyao , Lu Yizhou , Tian Dingkui , Liu Yi
Published: March 2021

The spring-loaded inverted pendulum model is similar to human walking in terms of the center of mass (CoM) trajectory and the ground reaction force. It is thus widely used in humanoid robot motion planning. A method that uses a velocity feedback controller to adjust the landing point of a robot leg is inaccurate in the presence of disturbances and a nonlinear optimization method with multiple variables is complicated and thus unsuitable for real-time control. In this paper, to achieve real-time optimization, a CoM-velocity feedback controller is used to calculate the virtual landing point. We construct a touchdown return map based on a virtual landing point and use nonlinear least squares to optimize spring stiffness. For robot whole-body control, hierarchical quadratic programming optimization is used to achieve strict task priority. The dynamic equation is given the highest priority and inverse dynamics are directly used to solve it, reducing the number of optimizations. Simulation and experimental results show that a force-controlled biped robot with the proposed method can stably walk on unknown uneven ground with a maximum obstacle height of 5 cm. The robot can recover from a 5 Nm disturbance during walking without falling.
A Digital Improvement—Trimming a Digital Temperature Sensor with EEPROM Reprogrammable Fuses
Authors: Vasile (Dragan) Anca Mihaela , Negut Alina , Tache Adrian , Brezeanu Gheorghe
Published: March 2021

An EEPROM (electrically erasable programmable read-only memory) reprogrammable fuse for trimming a digital temperature sensor is designed in a 0.18-µm CMOS EEPROM. The fuse uses EEPROM memory cells, which allow multiple programming cycles by modifying the stored data on the digital trim codes applied to the thermal sensor. By reprogramming the fuse, the temperature sensor can be adjusted with an increased trim variation in order to achieve higher accuracy. Experimental results for the trimmed digital sensor showed a +1.5/−1.0 ℃ inaccuracy in the temperature range of −20 to 125 ℃ for 25 trimmed DTS samples at 1.8 V by one-point calibration. Furthermore, an average mean of 0.40 ℃ and a standard deviation of 0.70 ℃ temperature error were obtained in the same temperature range for power supply voltages from 1.7 to 1.9 V. Thus, the digital sensor exhibits similar performances for the entire power supply range of 1.7 to 3.6 V.
Ghost Beam Suppression in Deep Frequency Modulation Interferometry for Compact On-Axis Optical Heads
Authors: Gerberding Oliver , Isleif Katharina-Sophie
Published: March 2021

We present a compact optical head design for wide-range and low noise displacement sensing using deep frequency modulation interferometry (DFMI). The on-axis beam topology is realised in a quasi-monolithic component and relies on cube beamsplitters and beam transmission through perpendicular surfaces to keep angular alignment constant when operating in air or in a vacuum, which leads to the generation of ghost beams that can limit the phase readout linearity. We investigated the coupling of these beams into the non-linear phase readout scheme of DFMI and implemented adjustments of the phase estimation algorithm to reduce this effect. This was done through a combination of balanced detection and the inherent orthogonality of beat signals with different relative time-delays in deep frequency modulation interferometry, which is a unique feature not available for heterodyne, quadrature or homodyne interferometry.
Modeling Capacitive Low-Power Voltage Transformer Behavior over Temperature and Frequency
Authors: Mingotti Alessandro , Costa Federica , Pasini Gaetano , Peretto Lorenzo , Tinarelli Roberto
Published: March 2021

The use of capacitive dividers (CDs) in medium-voltage (MV) networks started as simple voltage detectors and as rough voltage measurement instruments for protective purposes. Now, with the spread of intelligent electronic devices and renewable energy sources at the distribution level, capacitive dividers are designed and installed to perform accurate voltage measurements. Such a requirement is mandatory when the power quality has to be assessed. Therefore, CDs are currently being used either for power frequency or for high-frequency (supraharmonic- or partial-discharge-level) measurements. In this paper, typical off-the-shelf CDs are studied and modeled to understand how they behave in a wide range of frequencies and when the temperature varies. To this purpose, specific setups and tests have been developed and performed. From the results, it is clear that with proper modeling of CDs, it is possible to exploit them for measuring phenomena in a wide range of frequencies, including the effects due to temperature variations and self-resonances.
Case Report: Managing a COVID-19 Nursing Home Outbreak A Physician’s Perspective
Authors: Shalom Dr. Jim
Published: March 2021

I am the medical director and sole physician at a 35-bed nursing home in Western Galilee in Israel. At the end of December 2020, the nursing home experienced a COVID outbreak in which nineteen residents were infected. Four of them were symptomatic, and two died. Ten staff members, including our administrator, likewise caught the disease, and five of them were symptomatic. All recovered. The first part of this paper will examine why, despite all our precautions, the outbreak occurred when it did, and why it spread extensively within the home. The second part will describe how the nursing home functioned after the outbreak, until its residents recovered.
Cloud Computing of Network and Impact of Communication
Authors: Jbara Wurood A. , Ali Karrar Abdulkhabeer
Published: March 2021

Cloud computing has revolutionized economy and developed technology, in which computer resources are provided based on the Internet. In particular, these resources can be provisioned dynamically and released according to the service request and with minimal management effort. Cloud computing provides the best solution for managing data, infrastructure, and so forth. However, the security issue for data sent within a public cloud remains a challenge for cloud providers. Indeed, these data are the aim of some network attacks, which are intended to interrupt, modify, and manufacture information. Thus, it is crucial to take these attacks seriouslyin order to improve the use and adoption of the cloud. Through this article, we will present a detailed study of cloud security by providing the most important existing solutions in this area. Then, we will propose a concrete example of security based on a layered methodology.
BACTERIOLOGICAL PROFILE AND THEIR ANTIMICROBIAL SUSCEPTIBILITY
PATTERN IN CHILDREN OF OTITIS MEDIA WITH EAR DISCHARGE.
Authors: Sharma Richa , Gupta Prashant , Mishra Anupam
Published: March 2021

Background-Otitis media (OM) is one of the most common childhood infections in pre-school aged children and a major cause of childhood
morbidity. OM also represents the most frequent reason for antibiotic prescription in children. It is also the principal cause of childhood hearing loss
in India. Objectives- We aimed to study the microbiological prole and their antimicrobial sensitivity pattern in children of otitis media with ear
discharge in the tertiary care center in Lucknow and its application in the empirical treatment of otitis media. Methods: The study was conducted
from September 2017 to September 2018 on 150 children attending the ENT OPD and Microbiology Department having ear discharge. Ear
discharge samples were taken from 150 children (both male and female). Direct gram staining, KOH microscopy, and susceptibility testing were
carried out. Results: Among 150 cases, 10 cases were found to be of ASOM, and 140 of CSOM. Predominant organisms were Staphylococcus
species (22.67%), followed by Pseudomonas aeruginosa (22%), Klebsiella pneumoniae (10.7%), and Escherichia coli (10.7%). . Among
Staphylococcus aureus,55% were Methicillin sensitive Staphylococcus aureus (MSSA) and 45% were Methicillin-resistant Staphylococcus
aureus(MRSA). Only 1 Streptococcus pneumoniae was isolated among 10 ASOM cases. Staphylococcus species were found to be 100% sensitive
to linezolid and vancomycin, 80% to amikacin and trimethoprim-sulfamethoxazole, 53% to erythromycin, and 46% to clindamycin and
levooxacin. 91% isolates of Pseudomonas spp. were susceptible to piperacillin-tazobactam, 80% to cefepime, amikacin, and tobramycin, and
72% to gentamicin. Conclusion: The study of microbial patterns and their antibiotic sensitivity determines the prevalent bacterial organisms
causing otitis media in children in the local area and to start empirical treatment of otitis media and its complications for successful outcome, thus to
prevent the emergence of resistant strains.
EFFECTIVENESS OF A STRUCTURED TEACHING PROGRAMME ON ABG
ANALYSIS AND INTERPRETATION IN TERMS OF KNOWLEDGE AND PRACTICE
OF NURSING PERSONNEL
Authors: Negi Lovely , Verma Madhavi
Published: March 2021

Introduction: Even though Nursing Personnel take active participation in ABG analysis and interpretation on regular basis, there is a scope for
improvement to minimize errors and initiate prompt and appropriate interventions. The main aim of the study was to evaluate the effectiveness of
Structured Teaching Programme on ABG analysis and interpretation in terms of knowledge and practice of Nursing Personnel. Methods:
Quantitative research approach and pre-test post-test control group design was used. Total enumeration sampling was used to select Nursing
personnel working in Transplant ICU (Experimental group =22) and High Dependency Unit (control group = 25) of ILBS, New Delhi. Structured
knowledge questionnaire and observation practice checklist was used to collect data. Results: Total 22.7 % of experimental group and 44 % of
control group never attended any in-service education programme. Ahighly signicant difference was found between post-test knowledge scores
of both groups (t = 6.79; p < 0.001) and post-test practice scores of both groups (t = 12.79; p < 0.001). Conclusion: STPwas effective in enhancing
the knowledge and improving the practice of Nursing Personnel on ABG analysis and interpretation.
Implementation of Video Media to Improve Development of Early Religious and Moral Values of Children
Authors: Mike Oktavia Dewi , Dewi Madya Junaisih
Published: March 2021

This study aims to prove that there is an influence of the use of video media on the development of religious and moral values by introducing polite behavior. This research uses a quantitative quasi-experimental design with a pretest-posttest controlled group design model. Learning in the control group using a conventional model teacher-centered media storybook while the experimental group using the medium of video. This research was conducted in kindergarten TRI DHARMA sub-district Sukapura districts Probolinggo in group A with research subjects 20 children to group control and 20 children to experiment. From the results of this study indicate that the influence of experimental class children who use video media has an average higher when compared to the control class that uses conventional models that are centered on the teacher with the storybook media. The average score of the experimental class is 82.25 and the average number of the control class is 75.5. Based on the analysis of data that has been done that t arithmetic > t table, which is 2.163 > 2.08387. Thus it can be concluded that video media influences the development of religious and moral values of early childhood.
Interaksi Sosial Kaum Difable Netra
Authors: Moh.Wifaqul Idaini
Published: March 2021

Permasalahan diri seorang difable netra dalam berinteraksi adalah lambatnya penyesuaian diri difable netra, sebagai upaya untuk menumbuhkan kontak sosial difable netra adalah dengan melakukan berbagai kegiatan yang positif sebagai upaya untuk menyesuaikan diri. Penelitian ini bertujuan untuk memberikan kesinambungan antara kegiatan yang dilakukan difable netra dengan interaksi sosial difable netra. Kegiatan-kegiatan yang dilakukan difable netra mampu menjadi awal yang baik untuk melihat dan memulai bagaimana interaksi sosial difable netra. Interaksi difable netra dipengaruhi oleh beberapa faktor yaitu pentingnya pemaknaan terhadap perilaku manusia, pentingnya pengaturan diri, dan hubungan antara individu dan masyarakat. Penelitian ini ialah studi lapangan (field research) dengan menggunakan analisis deskriptif dan pendekatan kualitatif. Metode pengumpulan data yang digunakan adalah wawancara, observasi dan dokumentasi. Hasil dari riset ini adalah bahwa pandangan masyarakat terhadap difable (netra) mulai ada pergeseran makna ke arah positif. Hal demikian harus terus dikembangkan oleh berbagai pihak keluarga, masyarakat dan pemerintah untuk memberikan fasilitas-fasilitas yang dibutuhkan oleh difable netra. Dapat disimpulkan yaitu fenomena sosial yang sering terjadi di sekitar lingkungan masyarakat terhadap kemampuan yang berbeda pada diri seseorang sering dikaitkan dengan keterbatasan, kekurangan bahkan menjadikan bahan olok-olokkan sehingga membuat ruang gerak mereka menjadi penghalang dan terbatas dalam bergaul dan berinteraksi dengan lingkungannya. Permasalahan diri seorang difable netra dalam berinteraksi adalah lambatnya penyesuaian diri difable netra, sebagai upaya untuk menumbuhkan kontak sosial difable netra adalah dengan melakukan berbagai kegiatan yang positif sebagai upaya untuk menyesuaikan diri.
Penggunaan Aplikasi TEAMS dalam Pembelajaran Jarak Jauh di SMAN 18 Surabaya
Authors: Kartini Yusnawati
Published: March 2021

Tujuan penelitian ini untuk mengetahui sejauh mana adaptasi siswa kelas X terhadap tenaga pengajar dan pembelajaran melalui aplikasi TEAMS dari Microsoft Office 365 pada proses Pembelajaran Jarak Kauh selama masa pandemi sekarang ini. Metode yang digunakan penulis adalah penelitian kuantitatif dengan analisis deskriptif dengan melakukan observasi dan menyebarkan angket secara online kepada siswa kelas X. Berdasarkan hasil observasi dan angket menunjukkan bahwa dengan menggunakan aplikasi TEAMS siswa bisa belajar dengan baik, memberikan kesempatan untuk semakin mudah belajar dan siswa merasa senang karena bisa bertemu dengan guru dan bisa mendapatkan penjelasan dari tugas dan materi oleh guru meskipun secara virtual. Kesimpulannya siswa merasa aplikasi TEAMS telah memberikan mereka kesenangan dan kesempatan untuk tetap belajar di rumah dengan mudah selama proses Pembelajaran Jarak Jauh. Siswa dan guru tetap dapat melaksanakan proses belajar mengajar dengan efektif dan dapat melakukan adaptasi pembelajaran di masa pandemi covid 19 dengan menyenangkan meskipun harus belajar menggunakan aplikasi teknologi yang membutuhkan internet dan ponsel pintar atau komputer. Siswa dan guru saling menjaga semangat untuk melaksanakan proses belajar karena pendidikan tidak boleh terputus.
THE CONTRIBUTION OF GOVERNMENT SPONSORED HEALTH INSURANCE SCHEMES TOWARDS INDIAN HEALTH SECTOR
Authors: Dr.V.Pugazhenthi
Published: March 2021

Today, there are thirty four general insurance companies including the Export Credit Guarantee Corporation of India Ltd (ECGC) and Agriculture Insurance Corporation (AIC) of India and 24 life insurance companies operating in the country. Barring the AIC and ECGC, all other 32 insurers transact health insurance business, of whom six are stand-alone health insurers. Although there are number of insurers and different types of health insurance products available in the market, three-fourth health-insured Indians still gets covered only by a government-sponsored health insurance scheme (GSHIS) like PMJAY. Of all the health insurance premiums underwritten in the year 2019-20, 10 per cent came only from the GSHIS. In terms of number of persons covered, 73 per cent health-insured people are governed by one or other GSHIS. Looking at the profitability of the health insurer also, the incurred claims ratio is just 97.22 per cent in GSHISs. Thus, the health insurance premium, penetration and profitability—all of these are significantly sponsored and subsidized by the government through GSHIS, incorporating the public–private partnership (PPP) mode. This article details the role of GSHIS in the health insurance segment, taking the performances of the Indian health insurance sector in the year 2019-20.

KEYWORDS: Government sponsored health insurance schemes, health insurance, health premium, incurred claims ratio, insurance, insurance regulatory and development authority, standalone health insurers.
Inyiak Upiak Palatiang
Authors: Pardi Ari , Martarosa Martarosa , Rafilosa Rafilosa
Published: March 2021

Abstract                                                                                          

Inyiak Upiak Palatiang was born in 1900s in Kubu Gadang Hamlet, Nagari Gunuang, Padang Panjang City, he is famous as a pandeka (swordsman) Minangkabau silat girl who controls the flow of silek gunuang (Silat Gunung). (Interview with grandson Inyiak Upiak Palatiang, Fardizal, 20.00WIB, Padang Panjang, January 8, 2017). Inyiak Upiak Palatiang is a Minangkabau martial arts master, when he is 100 years old, he is still active in preserving and preserving the art of Minangkabau culture, even being a teacher of silek tuo (old martial arts), He is also known as a reliable kicker with various dendang creations besides Inyiak Upiak Palatiang also likes to play art Randai tradition. Based on the explanation of the greatness of Inyiak Upiak Palatiang, pengkarya plans to lift it into a musical masterpiece of the archipelago that will be titled "Inyak Upiak Palatiang", with the reason of the name of Inyiak Upiak Palatiang already representing what he cared for during his life. Background of the phenomenon that has been described, it can be formulated a formulation of the creation of the work, that is how to transform the phenomenon of a female character Inyiak Upiak Palatiang , into a musical composition of the archipelago, which will be divided into two sub-works, namely Upiak and Palatiang.

Keywords : Inyiak Upiak Palatiang, Women and Maestro

Abstrak

Inyiak Upiak Palatiang lahir pada tahun 1900-an di Dusun Kubu Gadang, Nagari Gunuang, Kota Padang Panjang ,beliau terkenal sebagai  seorang pandeka (pendekar) perempuan silat Minangkabau yang menguasai aliran silek gunuang (Silat Gunung). (Wawancara dengan cucu Inyiak Upiak Palatiang, Fardizal, 20.00WIB, Padang Panjang, 8 Januari 2017). Inyiak Upiak Palatiang adalah seorang maestro silat Minangkabau, disaat umur beliau 100 tahun, beliau masih aktif dalam menjaga dan melestarikan seni budaya Minangkabau, bahkan menjadi seorang guru silek tuo (silat tua), beliau juga dikenal sebagai seorang pendendang yang handal dengan berbagai dendang ciptaannya selain itu Inyiak Upiak Palatiang juga gemar bermain kesenian tradisi Randai.Berlatar belakang dari fenomena tersebut, menjadi ketertarikan bagi pengkarya untuk penciptaan karya musik, yaitu mentranformasikan fenomena seorang tokoh perempuan Inyiak Upiak Palatiang, kedalam sebuah bentuk komposisi musik nusantara, yang akan dibagi menjadi dua sub bagian karya, yaitu Upiak dan Palatiang.

Kata kunci : Inyiak Upiak Palatiang, Perempuan dan Maestro
PEMANFAATAN BATOK KELAPA SEBAGAI MEDIA PEMBUATAN BIO-INSTRUMEN MUSIK
Authors: Rahman Surya
Published: March 2021

Bio-musical instruments can be defined as musical instruments made from plant wastes in the surrounding environment. One of the plant waste that is easily found in the community is coconut shell. Coconut shells are often overlooked for their use as a creative medium, especially in the field of music. Musical instruments are the main media for creativity in the art of music. The rise of musical instruments or musical instruments with high prices has become one of the inhibiting factors for young people to be creative in the field of music. Seeing this phenomenon, it is deemed necessary to develop people's creativity in making their own musical instruments at economical prices but still able to compete with manufactured musical instruments. In making this bio-instrument, the method used consists of problem identification, preparation, application, and evaluation. Through this method, the results obtained in the use of coconut shell waste into creative media are the Kalimba instrument played by plucking the iron keys as the source of the tone, while the coconut shell is used as the main medium for the sound resonance of the Kalimba instrument. Kalimba is classified into a type of lamellophone instrument, which is a musical instrument that has a tongue or a thin plate. In addition to the easy-to-use manufacturing process, the tools and materials in making these instruments are also easy to find and can even take advantage of used materials. The results of making bio-musical instruments are expected to become a reference and reference for academics and non-academics, regarding how to make musical bio-instruments using coconut shell waste.