bluuebunny/crossref_metadata_2025 huggingface dataset:
General light-cone gauge approach to conformal fields and applications to scalar and vector fields
Authors: Metsaev R. R.
Published: February 2023

Abstract

Totally symmetric arbitrary spin conformal fields propagating in the flat space of even dimension greater than or equal to four are studied. For such fields, we develop a general ordinary-derivative light-cone gauge formalism and obtain restrictions imposed by the conformal algebra symmetries on interaction vertices. We apply our formalism for the detailed study of conformal scalar and vector fields. For such fields, all parity-even cubic interaction vertices are obtained. The cubic vertices obtained are presented in terms of dressing operators and undressed vertices. We show that the undressed vertices of the conformal scalar and vector fields are equal, up to overall factor, to the cubic vertices of massless scalar and vector fields. Various conjectures about interrelations between the cubic vertices for conformal fields in conformal invariant theories and the cubic vertices for massless fields in Poincaré invariant theories are proposed.
Development of an automated fibre placement-based hybrid composite wheel for a solar-powered car
Authors: Air Alexander , Shamsuddoha Md , Oromiehie Ebrahim , Prusty B. Gangadhara
Published: February 2023

Substantial range, handling and acceleration improvements in high-performance vehicles can be achieved by weight reduction. An important area for weight reduction on a car is the wheels. A novel prototype carbon fibre/epoxy wheel has been developed using a combination of automated fibre placement (AFP) and hand layup for the Sunswift 7 solar car. A three-piece wheel design that utilises each process where best suited has been analysed and optimised using the ANSYS ACP PrepPost suite, manufactured, and mechanically tested. The wheel disc was produced using AFP and featured selective reinforcement in the form of spokes. The AFP fibre paths for the disc have been optimised using CGTech’s VERICUT VCP and VCS to minimise gaps and overlaps, resulting in a 98.9% reduction in overlaps when compared with the unoptimised layup. The rim and tyre mounting region of the wheel have been manufactured using hand layup and adhesively bonded to the disc. This hybrid manufacturing approach has demonstrated an advancement in the feasibility of combining traditional and automated composite manufacturing. The final wheel weighed 3352 g, and the wheel deflection under a compressive load has been experimentally verified within 3% of the theoretical value.
Bootstrapping binary GEV regressions for imbalanced datasets
Authors: La Rocca Michele , Niglio Marcella , Restaino Marialuisa
Published: February 2023

This paper proposes and discusses a bootstrap scheme to make inferences when an imbalance in one of the levels of a binary variable affects both the dependent variable and some of the features. Specifically, the imbalance in the binary dependent variable is managed by adopting an asymmetric link function based on the quantile of the generalized extreme value (GEV) distribution, leading to a class of models called GEV regression. Within this framework, we propose using the fractional-random-weighted (FRW) bootstrap to obtain confidence intervals and implement a multiple testing procedure to identifying the set of relevant features. The main advantages of FRW bootstrap are as follows: (1) all observations belonging to the imbalanced class are always present in every bootstrap resample; (2) the bootstrap can be applied even when the complexity of the link function does not allow to easily compute second-order derivatives for the Hessian; (3) the bootstrap resampling scheme does not change whatever the link function is, and can be applied beyond the GEV link function used in this study. The performance of the FRW bootstrap in GEV regression modelling is evaluated using a detailed Monte Carlo simulation study, where the imbalance is present in the dependent variable and features. An application of the proposed methodology to a real dataset to analyze student churn in an Italian university is also discussed.
Clinical efficacy of flap transfer coverage in the treatment of vesicovaginal fistula
Authors: Wang Xingqi , Gao Zhenhua , Li Ling , Tian Daoming , Zhou Hang , Shen Jihong
Published: February 2023

Introduction and hypothesis

Vesicovaginal fistula (VVF) brings severe psychological, physiological, and social stress to patients, which seriously affects the quality of their sexual life. Traditional transvaginal repair surgery can cause vaginal shortening. Transferring the lateral free flap can maintain vaginal length. This study was carried out to investigate the clinical efficacy of the surgery of flap transfer coverage for treating VVF.

Methods

A retrospective analysis was performed on 37 patients diagnosed with VVF and repaired by flap transfer coverage in the Urogynecology department of the First Affiliated Hospital of Kunming Medical University from January 2018 to June 2021. All patients took a prone split leg position to repair VVF with the flap transfer covering method and a chart review was performed.

Results

Among the 37 patients, there were 34 cases of primary complete healing, and the success rate reached 91.89% without recurrence and complications. Three cases recurred with leakage of urine; cystoscopy showed that the fistula was significantly reduced, and all patients were cured after secondary repair by the same surgical method without complications.

Conclusions

Flap transfer coverage is a safe and effective surgical method for repairing VVF. The prone split leg position can better increase exposure. The fistula being away from the incision suture is the key to the success of the operation. Transferring the fistula can effectively improve the cure rate of VVF. Transferring the lateral free flap can maintain vaginal length.
Analysis of Hand Joint Space Morphology in Women and Men with Hereditary Hemochromatosis
Authors: Heilmeier Ursula , Burghardt Andrew J. , Tse Justin J. , Kapoor Puneet , Stok Kathryn S. , Manske Sarah , Voll Reinhard E. , Schett Georg , Finzel Stephanie
Published: February 2023

Hereditary hemochromatosis (HH) causes unbalanced iron deposition in many organs including the joints leading to severe cartilage loss and bone damage in the metacarpophalangeal joints (MCPJ). High-resolution peripheral quantitative computed tomography (HR-pQCT) and its joint space width (JSW) quantification algorithm quantifies in vivo 3D joint morphology. We therefore aimed to (i) determine feasibility and performance of the JSW algorithm in HH, (ii) quantify joint space morphology, and (iii) investigate the relationship between morphological and clinical parameters in HH. Here, we performed an exploratory study on 24 HH patients and sex- and age-matched controls using HR-pQCT imaging of MCPJ. Mineralized bone structure was automatically segmented from the grayscale image data and periosteal surface bone masks and joint space masks were generated. Mean, minimal, and maximal joint space width (JSW; JSW.MIN; JSW.MAX), JSW heterogeneity (JSW.SD), JSW asymmetry (JSW.AS), and joint space volume (JSV) were computed. Demographics and, for HH patients, disease-specific parameters were recorded. Segmentation of JS was very good with 79.7% of MCPJs successfully segmented at first attempt and 20.3% requiring semi-manual correction. HH men showed larger JSV at all MCPs (+ 25.4% < JSV <  + 41.8%, p < 0.05), larger JSW.MAX at MCP 3-4 (+ 14%, 0.006 < p < 0.062), and wider JSW (+ 13%, p = 0.043) at MCP 4 relative to HH women. Compared to controls, both HH men and HH women showed larger JSW.AS and smaller JSW.MIN at all MCP levels, reaching significance for HH men at MCP 2 and 3 (JSW.AS: + 323% < JSW.AS <  + 359%, 0.020 < p < 0.043; JSW.MIN: − 216% < JSW.MIN < − 225%, p < 0.043), and for women at MCP 3 (JSW.AS: + 180%, p = 0.025; JSW.MIN: − 41.8%, p = 0.022). Time since HH diagnosis was correlated positively with MCP 4 JSW.AS and JSW.SD (0.463 < ρ < 0.499, p < 0.040), and the number of phlebotomies since diagnosis was correlated with JSW.SD at all MCPs (0.432 < ρ < 0.535, p < 0.050). HR-pQCT-based JSW quantification in MCPJ of HH patients is feasible, performs well even in narrow JS, and allows to define the microstructural joint burden of HH.
A phase I, first-in-human study of TAK-164, an antibody–drug conjugate, in patients with advanced gastrointestinal cancers expressing guanylyl cyclase C
Authors: Kim Richard , Leal Alexis D. , Parikh Aparna , Ryan David P. , Wang Shining , Bahamon Brittany , Gupta Neeraj , Moss Aaron , Pye Joanna , Miao Harry , Inguilizian Haig , Cleary James M.
Published: February 2023

Purpose

Guanylyl cyclase C (GCC) is highly expressed in several gastrointestinal malignancies and preclinical studies suggest that it is a promising target for antibody-based therapeutics. This phase I trial assessed the safety and tolerability of TAK-164, an investigational, anti-GCC antibody–drug conjugate (NCT03449030).

Methods

Thirty-one patients with GCC-positive, advanced gastrointestinal cancers received intravenous TAK-164 on day 1 of 21-day cycles. Dose escalation proceeded based on cycle 1 safety data via a Bayesian model.

Results

Median age was 58 years (range 32–72), 25 patients (80.6%) had colorectal carcinoma, and median number of prior therapies was four. No dose-limiting toxicities (DLTs) were reported during cycle 1 DLT evaluation period. After cycle 2 dosing, 3 patients reported dose-limiting treatment-emergent adverse events (TEAEs): grade 3 pyrexia and grade 5 hepatic failure (0.19 mg/kg), grade 4 hepatic failure and platelet count decreased (0.25 mg/kg), grade 3 nausea, grade 4 platelet and neutrophil count decreased (0.25 mg/kg). The recommended phase II dose (RP2D) was 0.064 mg/kg. Common TAK-164-related TEAEs included platelet count decreased (58.1%), fatigue (38.7%), and anemia (32.3%). There was a dose-dependent increase in TAK-164 exposure over the range, 0.032–0.25 mg/kg. TAK-164 half-life ranged from 63.5 to 159 h. One patient (0.008 mg/kg) with high baseline GCC expression had an unconfirmed partial response.

Conclusions

TAK-164 appeared to have a manageable safety profile at 0.064 mg/kg. Hepatic toxicity was identified as a potential risk. The RP2D of 0.064 mg/kg was considered insufficient to derive clinical benefit; there are no plans for further clinical development.

Clinical Trial Registration

NCT03449030.
A coupled algebraic-delay differential system modeling tick-host interactive behavioural dynamics and multi-stability
Authors: Zhang Xue , Wu Jianhong
Published: February 2023

We propose a coupled system of delay-algebraic equations to describe tick attaching and host grooming behaviors in the tick-host interface, and use the model to understand how this tick-host interaction impacts the tick population dynamics. We consider two critical state variables, the loads of feeding ticks on host and the engorged ticks on the ground for ticks in a particular development stage (nymphal stage) and show that the model as a coupled system of delay differential equation and an algebraic (integral) equation may have rich structures of equilibrium states, leading to multi-stability. We perform asymptotic analyses and use the implicit function theorem to characterize the stability of these equilibrium states, and show that bi-stability and quadri-stability occur naturally in several combinations of tick attaching and host grooming behaviours. In particular, we show that in the case when host grooming is triggered by the tick biting, the system will have three stable equilibrium states including the extinction state, and two unstable equilibrium states. In addition, the two nontrivial stable equilibrium states correspond to a low attachment rate and a large number of feeding ticks, and a high attachment rate and a small number of feeding ticks, respectively.
Diet quality, food intake and incident adult-onset asthma: a Lifelines Cohort Study
Authors: Visser Edith , de Jong Kim , Pepels Janneke J. S. , Kerstjens Huib A. M. , ten Brinke Anneke , van Zutphen Tim
Published: February 2023

Purpose

Dietary factors have been suggested as drivers of the rising prevalence of adult-onset asthma, but evidence is inconclusive, possibly due to the complex interrelation with obesity. We aim to explore the relation of diet quality and food intake with incident adult-onset asthma in normal weight and overweight adults of the prospective population-based Lifelines Cohort Study.

Methods

Incident adult-onset asthma was defined as self-reported asthma at ± 4-year follow-up, in adults free of airway disease at baseline. Diet quality scores and food group intake were assessed at baseline. Log-binomial regression analyses were used to estimate adjusted relative risks (RR) between dietary intake (per portion) and incident adult-onset asthma, in categories of BMI (cutoff: 25 kg/m2).

Results

477 incident asthma cases (75% female, 62% overweight) and 34,698 controls (60% female, 53% overweight) were identified. Diet quality—assessed by the Lifelines Diet Score and Mediterranean Diet Score—was not associated with incident adult-onset asthma in the two BMI groups. Although the dietary intake of several food groups differed between cases and controls, after adjustment for confounders only few remained associated with adult-onset asthma, including red and processed meat (RR: 0.93 per 15 g intake; 95% CI 0.86–0.99) in the normal weight group and intake of cheese (RR 1.09 per 20 g intake; 95% CI 1.00–1.17) and vegetables (RR 1.10 per 50 g intake; 95% CI 1.00–1.21) in the overweight group.

Conclusion

The results of this study question the role of food as a ‘simple’ predictor of adult-onset asthma and call for an integrative approach, including a range of modifiable lifestyle factors and further asthma phenotyping.
Quality of life and clinical factors in women with endometriosis, the role of dienogest vs EE/dienogest over time: a single-center study
Authors: Maiorana Antonio , Alfano Pietro , Mercurio Antonella , Marcantonio Salvatore , Minneci Gabriella , Incandela Domenico , Audino Palma
Published: February 2023

Purpose

The aims of this observational study were: to assess the relationship between psychological variables, pain, Duration Untreated Endometriosis (DUE) in a sample of women with Endometriosis; and to assess the effect of dienogest 2 mg/daily (DNG) and dienogest/ethinylestradiol 0.03 mg/daily (EE/DNG) on Symptoms, QoL, HRQoL, pain and sexual satisfaction, over time.

Methods

64 women constituted the study group; (56%) took DNG and (44%) took EE/DNG. VAS, SF-36, EHP-30 and ISS were used to assess endometriosis-associated pelvic pain, QoL, HRQoL and sexual satisfaction, respectively. The study included one follow-up at 18 months.

Results

At T0, a longer period of DUE was related both to worst HRQoL and Physical QoL. At T1, a correlation was found between longer DUE and worst HRQoL. At T0, a negative correlation was found between VAS and PCS and between VAS and EHP-30. At T1, the same above correlation was found between VAS and PCS/MCS and VAS and EHP-30 scale. There was a correlation between ISS and VAS. ANOVA showed a reduction in dysmenorrhea, in general pain level and an improvement in emotional wellbeing, relationship with medical profession, and PCS over time, regardless to type of treatment. Moreover, a significant time × treatment group interaction for dysmenorrhea was found.

Conclusion

DUE and pain are important variables related to psychological aspects of women with endometriosis. Treatment with both DNG and EE/DNG may have positive effects on the QoL, HRQoL and symptoms. Moreover, DNG seems to have a greater effect than EE/DNG on dyspareunia reduction over time.
Effects of CFTR-modulator triple therapy on sinunasal symptoms in children and adults with cystic fibrosis
Authors: Bode Sebastian F. N. , Rapp Hannes , Lienert Nadine , Appel Heike , Fabricius Dorit
Published: February 2023

Purpose

Sinunasal symptoms and chronic rhinusinutitis are common in patients with cystic fibrosis. Cystic fibrosis transmembrane regulator (CFTR) modulators have led to dramatic improvements of respiratory symptoms and quality of life in patients with cystic fibrosis. This study aims to evaluate subjective and objective sinunasal symptoms after start of CFTR-modulator triple therapy.

Methods

43 patients (n = 6 < 18 years), treated with highly effective CFTR-modulator therapy with elexacaftor–tezacaftor–ivacaftor (ELX/TEZ/IVA) were included, as were 20 controls with cystic fibrosis but without CFTR-modulator therapy (n = 6 < 18 years). All assessed their sinunasal symptoms retrospectively and the intervention group at a mean of 9.3 (2–16) months after start of ELX/TEZ/IVA.

Results

Improvements in SNOT-22 overall score from m = 32.7 to m = 15.7 points (p < 0.0001) as well in the nasal, emotional, otologic, and sleep subdomains could be demonstrated in the intervention group. No changes were found in the control group. Children showed lower SNOT-22 scores than adults and a reduction of SNOT-22 total score from m = 9.4 to m = 2.2 (p = 0.25) was found. 8 patients were evaluated by an otorhinolaryngologist before and after start of ELX/TEZ/IVA and showed pronounced objective clinical improvement.

Conclusions

Highly effective CFTR-modulator therapy has a significant positive impact on both subjective and objective sinunasal symptoms in patients with CF and some improvement could be demonstrated in children < 18 years as well.
High levels of childhood trauma associated with changes in hippocampal functional activity and connectivity in young adults during novelty salience
Authors: Derome Mélodie , Machon Sandra , Barker Holly , Kozhuharova Petya , Orlov Natasza , Morgenroth Elenor , Hugdahl Kenneth , Allen Paul
Published: February 2023

Childhood trauma (CT) has been linked to increased risk for psychosis. Moreover, CT has been linked to psychosis phenotypes such as impaired cognitive and sensory functions involved in the detection of novel sensory stimuli. Our objective was to investigate if CT was associated with changes in hippocampal and superior temporal gyrus functional activation and connectivity during a novelty detection task. Fifty-eight young adults were assigned to High-CT (n = 28) and Low-CT (n = 24) groups based on their scores on the childhood trauma questionnaire (CTQ) and underwent functional Magnetic Resonance Imaging during an auditory oddball task (AOT). Relative to the Low CT group, High CT participants showed reduced functional activation in the left hippocampus during the unpredictable tone condition of the AOT. Furthermore, in the High CT group, psychophysiological interaction analysis revealed hypoconnectivity between the hippocampus and temporal and medial regions. The present study indicates both altered hippocampal activation and hippocampal-temporal-prefrontal connectivity during novelty detection in individuals that experienced CT, similarly to that reported in psychosis risk populations. Early stressful experiences and environments may alter hippocampal function during salient events, mediating the relationship between childhood trauma and psychosis risk.
An experimental investigation of factors controlling the oxygen content of sulphide melts in the Earth’s upper mantle
Authors: Abeykoon Sumith , Laurenz Vera , Frost Daniel J. , Miyajima Nobuyoshi , McCammon Catherine
Published: February 2023

To determine the factors that control the oxygen content of sulphide melts in the upper mantle, mono-sulphides were equilibrated with mantle peridotite assemblages, with varying FeO and NiO contents, between 3 and 13 GPa and 1300 to 1819 °C. Carbonates were added as a flux and the use of graphite capsules allowed oxygen fugacities (fo2) to be estimated for most of the experiments. Sulphide melt O concentrations were in the range 0.2–3.7 wt. %, coexisting with silicate assemblages with olivine Fe/(Fe + Mg) ratios between 0.04 and 0.25. Except in Ni-bearing experiments, variations in the sulphur/metal cation ratio did not affect the sulphide melt O contents, which also appeared to be independent of fo2. The silicate FeO contents, temperature and pressure were found to be the main controls on O contents. Nickel lowers the O content, although all Ni-bearing experiments produced sulphides with lower sulphur/metal ratios, making it difficult to categorically separate the effect of Ni alone. A preliminary geothermometer expression was developed based on the O content of the sulphide melts and the iron oxide concentrations of coexisting olivine and orthopyroxene. With this expression, the experimental temperatures are reproduced to within 74 K for Ni-free experiments and within 135 K for Ni-bearing samples. Using measurements of the O contents of sulphide inclusions of peridotite affinity in diamonds from the Lac de Gras kimberlite field, a plausible average entrapment temperature of 1318 ± 48 °C is calculated. Mantle peridotite assemblages would be expected to contain sulphide melts with approximately 0.4–0.6 wt. % O along a typical mantle adiabat down to 200 km depth.
The phenotypic spectrum of pathogenic ATP1A1 variants expands: the novel p.P600R substitution causes demyelinating Charcot–Marie–Tooth disease
Authors: Cinarli Yuksel Feride , Nicolaou Paschalis , Spontarelli Kerri , Dohrn Maike F. , Rebelo Adriana P. , Koutsou Pantelitsa , Georghiou Anthi , Artigas Pablo , Züchner Stephan L. , Kleopa Kleopas A. , Christodoulou Kyproula
Published: February 2023

Background

Charcot–Marie–Tooth disease (CMT) is a genetically and clinically heterogeneous group of inherited neuropathies. Monoallelic pathogenic variants in ATP1A1 were associated with axonal and intermediate CMT. ATP1A1 encodes for the catalytic α1 subunit of the Na+/ K+ ATPase. Besides neuropathy, other associated phenotypes are spastic paraplegia, intellectual disability, and renal hypomagnesemia. We hereby report the first demyelinating CMT case due to a novel ATP1A1 variant.

Methods

Whole-exome sequencing on the patient’s genomic DNA and Sanger sequencing to validate and confirm the segregation of the identified p.P600R ATP1A1 variation were performed. To evaluate functional effects, blood-derived mRNA and protein levels of ATP1A1 and the auxiliary β1 subunit encoded by ATP1B1 were investigated. The ouabain-survival assay was performed in transfected HEK cells to assess cell viability, and two-electrode voltage clamp studies were performed in Xenopus oocytes.

Results

The variant was absent in the local and global control datasets, falls within a highly conserved protein position, and is in a missense-constrained region. The expression levels of ATP1A1 and ATP1B1 were significantly reduced in the patient compared to healthy controls. Electrophysiology indicated that ATP1A1p.P600R injected Xenopus oocytes have reduced Na+/ K+ ATPase function. Moreover, HEK cells transfected with a construct encoding ATP1A1p.P600R harbouring variants that confers ouabain insensitivity displayed a significant decrease in cell viability after ouabain treatment compared to the wild type, further supporting the pathogenicity of this variant.

Conclusion

Our results further confirm the causative role of ATP1A1 in peripheral neuropathy and broaden the mutational and phenotypic spectrum of ATP1A1-associated CMT.
Hyperlipidemia in tendon injury: chronicles of low-density lipoproteins
Authors: Fang William H. , Bonavida Victor , Agrawal Devendra K. , Thankam Finosh G.
Published: February 2023

Hyperlipidemia impacts millions of people globally and has been the major risk factor for developing atherosclerosis and cardiovascular disease. Interestingly, hyperlipidemic subjects exhibit increased incidence of rotator cuff tendon injury (RCTI) and disorganization of tendon matrix. Low-density lipoproteins (LDL) and its oxidized form (ox-LDL) play a crucial role in hyperlipidemia-driven pro-inflammatory responses in multiple tissues including the tendon. The signaling of oxLDL upregulates the inflammatory cytokines, chemokines, adhesion molecules, and the activation of monocytes/macrophages/resident tendon cells and matrix metalloproteinases impairing the tendon homeostasis resulting in the alteration of extracellular matrix. In addition, the hyperlipidemia-driven immune response and subsequent oxidative stress promote degenerative responses in the tendon tissue. However, the pathological mechanisms underlying the occurrence of RCTI in hyperlipidemia and the effect of ox-LDL in tendon matrix are currently unknown. The present review focuses on the implications and perspectives of LDL/oxLDL on the increased incidence of RCTI.
Dealing with disjunct populations of vascular plants: implications for assessing the effect of climate change
Authors: Varaldo Lucia , Guerrina Maria , Dagnino Davide , Minuto Luigi , Casazza Gabriele
Published: February 2023

Species distribution models are the most widely used tool to predict species distributions for species conservation and assessment of climate change impact. However, they usually do not consider intraspecific ecological variation exhibited by many species. Overlooking the potential differentiation among groups of populations may lead to misplacing any conservation actions. This issue may be particularly relevant in species in which few populations with potential local adaptation occur, as in species with disjunct populations. Here, we used ecological niche modeling to analyze how the projections of current and future climatically suitable areas of 12 plant species can be affected using the whole taxa occurrences compared to occurrences from geographically disjunct populations. Niche analyses suggest that usually the disjunct group of populations selects the climatic conditions as similar as possible to the other according to climate availability. Integrating intraspecific variability only slightly increases models’ ability to predict species occurrences. However, it results in different predictions of the magnitude of range change. In some species, integrating or not integrating intraspecific variability may lead to opposite trend in projected range change. Our results suggest that integrating intraspecific variability does not strongly improve overall models’ accuracy, but it can result in considerably different conclusions about future range change. Consequently, accounting for intraspecific differentiation may enable the detection of potential local adaptations to new climate and so to design targeted conservation strategies.
A model volcanic fissure with adjustable geometry and wall temperature
Authors: Cole R. P. , White J. D. L. , Baxter R. J. M. , Bowman M. H. , Dürig T. , Fleming M. , Pooley B. ,   Farra Engineering Ltd, Ruz-Ginouves J. , Gudmundsson M. T. , Cronin S. J. , Leonard G. S. , Valentine G. A.
Published: February 2023

Fissure eruptions initiate with magma ascending and spreading through cracks in the ground that can extend for kilometres at the surface. Eruptions eventually localise to form one or a few persistent conduits and ultimately an array of discrete cones or craters. We built a new experimental apparatus to investigate the influences of fissure shape and wall-rock temperature on localisation within a volcanic fissure, and the thermal feedbacks associated with variability of these parameters. Our artificial fissure, or “Artfish,” has a slot geometry with adjustable shape and wall temperature. We can simulate both starting variability in fissure geometry and wall temperature, as well as changes in these parameters during an experiment to replicate, for example, blockage by wall-rock collapse, widening by wall-rock erosion, and warming by adjacent intrusions. We use polyethylene glycol (PEG 600) for our analogue fluid. A variable-speed pump allows for a range of fluid injection and ascent rates. Initial tests showcase the capabilities of the model and the types of data that may be acquired. Additional key features achieved include a stable and planar injection system, fluid recycling, and the use of particle tracers for monitoring flow patterns and velocities. The thermal evolution of the fluid-wall interface is quantitatively measured with thermal sensors, and the change in state of the PEG provides a clear visual indication of flow behaviour and solidification progress recorded on video. The potential experiments that can be conducted with this highly versatile model are numerous and will be used to gain a better understanding of the thermal controls on flow localisation and conduit development. This will assist hazard modellers to assess controls on eruption evolution and potentially to forecast sites where an initial fissure eruption may focus.
Low pretherapy skeletal muscle mass index is associated with an increased risk of febrile neutropenia in patients with esophageal cancer receiving docetaxel + cisplatin + 5-fluorouracil (DCF) therapy
Authors: Nara Katsuhiko , Yamamoto Takehito , Sato Yasuyoshi , Yagi Koichi , Kawasaki Koichiro , Toriumi Tetsuro , Takada Tappei , Seto Yasuyuki , Suzuki Hiroshi
Published: February 2023

Purpose

Docetaxel + cisplatin + 5-fluorouracil (DCF) therapy, a frequently prescribed regimen for esophageal cancer, is associated with a high risk of febrile neutropenia (FN). This study investigated whether a low skeletal muscle mass index (SMI) is an independent risk factor for FN.

Methods

This retrospective, observational study investigated the SMI of patients with esophageal cancer who received DCF therapy between March 2018 and July 2020. Based on the Asian sarcopenia criteria, patients were divided into two groups: high and low SMI (SMI of < 7.0 and 5.7 kg/m2 for males and females, respectively). The incidence of FN was then compared between the two groups.

Results

Thirty-nine patients (20 and 19 in the high- and low-SMI groups, respectively) were included in this study. The incidence of FN was significantly higher in the low-SMI group (63.2% vs. 20.0%, P = 0.006). Univariable and multivariable logistic regression analyses revealed that a low SMI was an independent risk factor for FN (odds ratio, 7.178; 95% confidence interval, 1.272–40.507; P = 0.026). In addition, the frequency of dose reduction in DCF therapy was significantly higher in the low-SMI group (68.4% vs. 35.0%, P = 0.037).

Conclusion

Low SMI is an independent risk factor for FN in patients with esophageal cancer receiving DCF therapy.
Almost 2 years into the COVID-19 pandemic: an update on parental stress, parent mental health, and the occurrence of child maltreatment
Authors: Calvano Claudia , Engelke Lara , Holl-Etten Anna Katharina , Renneberg Babette , Winter Sibylle M.
Published: February 2023

Increased parental stress, poorer mental health, and an increase in the occurrence of child maltreatment (CM) have been reported in earlier phases of the COVID-19 pandemic. However, data from later phases of the pandemic are not yet available. We conducted a cross-sectional, representative survey among 1087 parents (48.8% female; mean age 41.72 years, SD = 9.15) in Germany in December 2021. Data were compared to a previous representative sample, assessed in August 2020 (N = 1024), and to normative scores of the outcome measures. Predictors for the occurrence of CM were analyzed by logistic regression. Pandemic-related stress and general stress were higher and physical and mental health were poorer in the December 2021 sample than in the August 2020 sample. Occurrence rates of CM varied between 5 and 56%. Verbal emotional abuse (n = 607, 56%), witnessing domestic violence (n = 446, 41%), and emotional neglect (n = 435, 40%) were most frequently reported. For these subtypes, parental risk for alcohol abuse (OR 2.1–2.7) and parental recent experience of violence (OR 2.1–5.1) were the strongest predictors. Across all subtypes of CM, parents reporting child maltreatment showed poorer scores on all stress outcomes, with medium–large-effect sizes. Results confirm a high burden within the families, almost 2 years into the pandemic. Occurrence rates of a broad spectrum of CM subtypes raise further concerns for the well-being of children. Family-oriented intervention efforts are needed to stabilize families and provide targeted support. Longitudinal studies are needed for a description of families at risk for poorer outcomes.
Benefits of electrochemistry studies for the majority of students who will not become electrochemists
Authors: Scholz Fritz
Published: February 2023

In teaching electrochemistry, it is of primary importance to make students always aware of the relations between electrochemistry and all the non-electrochemical topics, which are taught. The vast majority of students will not specialise in electrochemistry, but they all can very much benefit from the basics and concepts of electrochemistry. This paper is aimed to give suggestions how the teaching of electrochemistry can easily be interrelated to topics of inorganic, organic, analytical, environmental chemistry, biochemistry and biotechnology.
Wasserstein barycenter regression for estimating the joint dynamics of renewable and fossil fuel energy indices
Authors: De Giuli Maria Elena , Spelta Alessandro
Published: February 2023

In order to characterize non-linear system dynamics and to generate term structures of joint distributions, we propose a flexible and multidimensional approach, which exploits Wasserstein barycentric coordinates for histograms. We apply this methodology to study the relationships between the performance in the European market of the renewable energy sector and that of the fossil fuel energy one. Our methodology allows us to estimate the term structure of conditional joint distributions. This optimal barycentric interpolation can be interpreted as a posterior version of the joint distribution with respect to the prior contained in the past histograms history. Once the underlying dynamics mechanism among the set of variables are obtained as optimal Wasserstein barycentric coordinates, the learned dynamic rules can be used to generate term structures of joint distributions.
SARS-CoV-2 epidemiological trend before vaccination era: a seroprevalence study in Apulia, Southern Italy, in 2020
Authors: Marchi Serena , Coppola Chiara , Piu Pietro , Benincasa Linda , Dapporto Francesca , Manenti Alessandro , Viviani Simonetta , Montomoli Emanuele , Trombetta Claudia Maria
Published: February 2023

Aim

The present study aimed at assessing the prevalence of antibodies against SARS-CoV-2 in the general population in the province of Bari (Apulia region, Southern Italy) during the year 2020.

Subject and methods

In this study, 1325 serum samples collected from January to December 2020 were tested for the presence of IgM and IgG antibodies against whole-virus SARS-CoV-2 antigen by commercial ELISA. Positive samples were further tested by in-house ELISA for the detection of anti-receptor binding domain (RBD) IgM and IgG antibodies and by micro-neutralization (MN) assay for the detection of neutralizing antibody.

Results

One hundred (7.55%) samples had the presence of at least one antibody class against SARS-CoV-2 by commercial ELISA, of which 88 (6.6%) showed IgG and 19 (1.4%) showed IgM antibodies. The proportion of samples with IgG antibodies increased from 1.9% in January–February to 9.6% in November–December, while no significant increase was observed for IgM. When tested by in-house ELISA and MN assay, 17.0% and 31.6% were found positive to RBD IgG and RBD IgM, respectively, while 12.0% showed neutralizing antibody.

Conclusion

The proportion of samples with SARS-CoV-2 IgG antibodies increased during 2020, especially in the second half of the year, consistent with data reported by the routine epidemiological surveillance of SARS-CoV-2 cases. Despite the high number of reported cases, the seroprevalence values are relatively low, and only a small proportion of samples had neutralizing antibodies.
A Systematic Review and Lived Experience Synthesis of Self-disclosure as an Active Ingredient in Interventions for Adolescents and Young Adults with Anxiety and Depression
Authors: Gonsalves Pattie P. , Nair Rithika , Roy Madhavi , Pal Sweta , Michelson Daniel
Published: February 2023

Self-disclosure, referring to the ability to communicate and share intimate personal feelings, has strong face validity for many young people as a way of improving anxiety and depression outcomes. The current review aimed to generate the first comprehensive evidence synthesis of self-disclosure interventions involving young people aged 14–24 years who are either disclosers or recipients of personal information about living with anxiety and/or depression. A systematic review of quantitative and qualitative data was combined with new insights from an adolescents and young adults lived-experience panel (n = 7) with the intention to combine rigorous systematic review methods and experiential knowledge. Six studies of variable quality were included in this review, five were quantitative and one was qualitative. Findings suggest that self-disclosure may be effective at reducing symptoms for adolescents and young adults with established depression; effects were not apparent when delivered as early prevention. No evidence for impacts on anxiety was found. The potential for negative effects like bullying or harassment was identified. Findings were limited by a small number of studies; low representation of peer-reviewed studies from low-or middle-income countries; and varied interventions in terms of format, participants' context, and nature of delivery. Self-disclosure may be of value in the context of interventions intended explicitly to reduce depression for those already showing symptoms. Delivery by non-specialists (such as peers and teachers) in addition to mental health professionals can help build capacity in community health systems. Self-disclosure may also be helpful at reducing stigma and stimulating help-seeking at earlier stages of mental health problems.
Promoting Prescription Drug Safety Skills in School: Evaluating the Effectiveness of a Technology-Based Curriculum
Authors: Smart Mieka , Lynch Alicia Doyle , Callina Kristina Schmid , Richer Amanda , Mulheron Megan , Zapp Daniel
Published: February 2023

Background

Prescription drug misuse among youth aged 12–18 remains high in the United States. Grounded in Social Norms Theory, school-based curricula have been shown to effectively challenge students’ misperceptions of peer norms and safety regarding prescription drug misuse (PDM).

Objective

The present study is a quasi-experimental evaluation of a brief, no cost, school-based prescription drug safety program.

Methods

Participants included 94 teachers and their students (n = 2325) in grades 8 through 12. Teachers (and their students) were assigned to experimental or control conditions. Using a pre-/post-survey design, we examined whether the curriculum promoted growth in five key student outcomes: Personal Responsibility, Social Norms, Knowledge, Future Actions, and Refusal Skills. Student demographic characteristics and prescription drug history were examined as moderators of growth. Within the experimental group, variation in implementation factors such as teachers’ prior experience with the program and perceptions of student engagement were examined as moderators of the effectiveness of the curriculum.

Results

Multilevel models demonstrated equitable growth in Personal Responsibility, Social Norms, Knowledge, Future Actions, and Refusal Skills across gender, race, and other demographic characteristics. Students’ prescription drug history was not associated with growth on the five key outcomes. Growth in Personal Responsibility, Social Norms, Knowledge, and Future Actions was maintained in a one-month follow-up survey. Teacher perceptions of student engagement were associated with lower growth in Social Norms.

Conclusions

The findings suggest promising implications for the scalability of an effective, brief, no cost, technology-based intervention targeting adolescent PDM.
The Effectiveness of School-Based Skills-Training Programs Reducing Performance or Social Anxiety: Two Randomized Controlled Trials
Authors: van Loon Amanda W. G. , Creemers Hanneke E. , Vogelaar Simone , Miers Anne C. , Saab Nadira , Westenberg P. Michiel , Asscher Jessica J.
Published: February 2023

Background

Given that high levels of stress during adolescence are associated with negative consequences, it is important that adolescents with psychological needs are supported at an early stage, for instance with interventions at school. However, knowledge about the potential of school-based programs targeting adolescents with psychological needs, aimed at reducing school or social stress, is lacking.

Objective

The current study aimed to investigate the effectiveness of two targeted school-based skills-training programs, addressing either skills to deal with performance anxiety or social skills.

Methods

Two randomized controlled trials were performed with participants who self-selected to one of the programs. The sample comprised of N = 361 adolescents (Mage = 13.99 years, SD = 0.83) from various educational levels and ethnic identity backgrounds. The performance anxiety program included N = 196 participants (N = 95 in the experimental group), while the social skills program included N = 165 participants (N = 86 in the experimental group). MANCOVA’s were performed.

Results

The performance anxiety program had a small effect on reducing adolescents’ test anxiety. Furthermore, for adolescents who attended more than half of the sessions, the program had small effects on reducing test anxiety and fear of failure. The program did not improve adolescents’ coping skills or mental health. The social skills program was not effective in improving social skills, social anxiety, and mental health.

Conclusions

A relatively short, targeted program addressing skills to deal with performance anxiety can have the potential to reduce adolescents’ performance anxiety.

Trial registration

International Clinical Trials Registry Platform (Netherlands Trial Register, number NTR7680). Registered 12 December 2018. Study protocol van Loon et al., (2019).
A Dodgson-Hare synthesis
Authors: Green-Armytage James
Published: February 2023

In 1876, Charles Dodgson (better known as Lewis Carroll) proposed a committee election procedure that chooses the Condorcet winner when one exists and otherwise eliminates candidates outside the Smith set, then allows for re-votes until a Condorcet winner emerges. The present paper discusses Dodgson’s work in the context of strategic election behavior and suggests a “Dodgson-Hare” method: a variation on Dodgson’s procedure, for use in public elections. This method allows for candidate withdrawal and employs Hare’s plurality-loser-elimination method to resolve persistent cycles. Given plausible assumptions about how candidates decide whether to withdraw when there is a cycle, Dodgson-Hare outperforms Hare, Condorcet-Hare, and 12 other voting rules in a series of spatial-model simulations that count how often each rule is vulnerable to coalitional manipulation. In the case of a one-dimensional spatial model, all coalitional voting strategies that are possible under Condorcet-Hare can be undone in Dodgson-Hare, by the withdrawal of candidates who have incentive to withdraw.
SARS-CoV-2 elicits non-sterilizing immunity and evades vaccine-induced immunity: implications for future vaccination strategies
Authors: Beukenhorst Anna L. , Koch Clarissa M. , Hadjichrysanthou Christoforos , Alter Galit , de Wolf Frank , Anderson Roy M. , Goudsmit Jaap
Published: February 2023

Neither vaccination nor natural infection result in long-lasting protection against SARS-COV-2 infection and transmission, but both reduce the risk of severe COVID-19. To generate insights into optimal vaccination strategies for prevention of severe COVID-19 in the population, we extended a Susceptible-Exposed-Infectious-Removed (SEIR) mathematical model to compare the impact of vaccines that are highly protective against severe COVID-19 but not against infection and transmission, with those that block SARS-CoV-2 infection. Our analysis shows that vaccination strategies focusing on the prevention of severe COVID-19 are more effective than those focusing on creating of herd immunity. Key uncertainties that would affect the choice of vaccination strategies are: (1) the duration of protection against severe disease, (2) the protection against severe disease from variants that escape vaccine-induced immunity, (3) the incidence of long-COVID and level of protection provided by the vaccine, and (4) the rate of serious adverse events following vaccination, stratified by demographic variables.
Collegiality, Friendship, and the Value of Remote Work
Authors: Mlonyeni Philip Maxwell Thingbø
Published: February 2023

Philosophers have not paid much attention to the impact of remote work on the nature of work and the workplace. The overall aim of this paper is to contribute to further debate over the value of remote work by focusing on one important dimension of it – the effect on collegial relationships.

I distinguish two types of collegial relationships. On the one hand, there are what I call “Kantian collegial relationships”, which have been outlined in a recent account by Betzler & Löschke. These are colleagues who acknowledge and respect each other as equals, and provide relationship goods in a fair and distributive manner. On the other hand, there are what I call “collegial friendships”. In contrast to Kantian colleagues, collegial friends are emotionally supportive and show appreciation for each other for who they are, not just because they are equals. Both types of collegial relationship must be taken into consideration if we want to fully understand why we value our colleagues.

I then show that there are reasons to believe that remote work will have a chilling effect on collegial friendships. Remote workers must interact online, which undermines forms of self-disclosure that are necessary for intimate relationships to form, like collegial friendship. Conversely, I suggest that remote work, for exactly the same reasons, will have a positive effect on Kantian collegial relationships. The proliferation of remote work forces us to consider whether this tradeoff is acceptable.
Efficacy of peritoneal dialysis in patients with refractory congestive heart failure: a systematic review and meta-analysis
Authors: Timóteo Ana Teresa , Mano Tânia Branco
Published: February 2023

Refractory congestive heart failure (RCHF) is a common complication in the natural history of advanced heart failure. Peritoneal dialysis (PD) is a possible alternative in those patients, but studies are scarce, and mostly with small samples. We conducted this meta-analysis to evaluate the effects of PD in patients with RCHF. Articles published before July 2020 in the following databases: PubMed, Web of Science, and CENTRAL. Mean differences (MD) and 95% confidence intervals (CIs) were computed to generate a pooled effect size with a random effects model. We also assessed heterogeneity, risk of bias, publication bias, and quality of evidence. Twenty observational studies (n = 769) were included, with a “before and after intervention” design. PD was associated with a significant reduction in NYHA functional class (MD −1.37, 95% CI −0.78 to −1.96) and length of hospitalisation (MD −34.8, 95% CI −20.6 to −48.9 days/patient/year), a small but significant increase in left ventricular ejection fraction (MD 4.3, 95%CI 1.9 to 6.8%) and a non-significant change in glomerular filtration rate (MD −3.0, 95% CI −6.0 to 0 mL/min/1.73m2). Heterogeneity among studies was significant and overall risk of bias was rated from moderate to critical. No significant publication bias was found, and the overall quality of evidence was very low for all outcomes. PD in patients with RCHF improved functional class, length of hospitalisation, and ventricular functional, and had no impact in renal function. Further randomised clinical trials are warranted to confirm our results that showed some limitations.