bluuebunny/crossref_metadata_2025 huggingface dataset:
Бета-казеин коровьего молока и его влияние на организм человека (обзор)
Authors:   Northern State Medical University, Pankov Mikhail N. , Smolina Viktoriya S. , Stupina Aleksandra O. ,   N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences, Klassen Inga A. , Spasskiy Evgeniy A.
Published: October 2024

Cow’s milk is an important food product for humans since it has a complex chemical composition and high nutritional value. Over 140 fatty acids, including linoleic, linolenic and arachidonic acids, were found in milk’s lipid profile. Milk is rich in minerals and contains almost all fat-soluble and water-soluble vitamins. Milk proteins are a complete source of all essential amino acids for humans. Approximately 78 % of the total amount of protein in milk is casein. Beta-casein is one of the most important proteins in cow’s milk, accounting for up to 35 % of all milk proteins. It is believed that the A2A2 allele of the β-casein gene allows animals to produce а more nutritionally valuable milk since in this case, during the cleavage of β-casein in the human gastrointestinal tract, β-casomorphin-7 is either not produced or is produced in much smaller (trace) amounts than in the case of the А1А1 allele, which makes the process of milk digestion more physiological. Research has shown a link between β-casomorphin-7 and a variety of negative effects that occur both directly in the gastrointestinal tract and throughout the human body, contributing to the development of numerous pathologies, in particular type 1 diabetes mellitus, cardiac diseases, and various neurological disorders. A comprehensive study involving preschool children demonstrated that replacing regular milk with milk containing only A2А2 β-casein led to a significant reduction in complications associated with gastrointestinal intolerance as well as to improved cognitive functions.
Английские вторично-предикативные структуры в медицинском дискурсе: к проблеме классификации
Authors:   Northern (Arctic) Federal University named after M.V. Lomonosov, Pak Natalya S.D.
Published: October 2024

English secondary-predicative structures have been sufficiently studied within various paradigms and approaches. Nevertheless, research on this phenomenon is still relevant at the intersection of grammar and discourse as a cognitive phenomenon related to the creation, operation and transmission of knowledge. From this point of view, the semi-complex sentence with secondary-predicative structures is seen as a reflection of cognitive processing of knowledge and its integration to create new knowledge. The aim of this paper is to identify the peculiarities of English secondary-predicative structures in medical discourse and to classify them according to their cognitive characteristics and key parameters of medical discourse (in particular, the chronotope). The material of the study is a corpus of English semi-complex sentences with secondary-predicative structures extracted by means of continuous sampling from texts representing various written genres of medical discourse. The research methodology is based on the integrative approach and includes both linguistic methods (linguistic analysis, transformational analysis, etc.) and methods involving the application of artificial intelligence (e.g. word cloud automatic keyword extraction). The cognitive basis for choosing secondary-predicative structures is the conceptual integration between the proposition represented by the secondary-predicative structure and the proposition represented by the matrix sentence, as well as the characteristics of the medical discourse chronotope. In addition, a subclassification of secondary-predicative structures by the intensity of representation of the medical discourse chronotope is proposed.
Человек (не)античный: философская антропология молодого Ницше
Authors:   Samara State Technical University, Faritov Vyacheslav T.
Published: October 2024

This article analyses the philosophical and anthropological views of Friedrich Nietzsche in the early period of his writing (1869–1873). The paper aims to identify the origin, genesis and transformations of those ideas with which Nietzsche’s philosophy would subsequently be associated: overman, the death of God, and the eternal return. The methodology of the study is based on the fundamental principles and ideas of comparative philosophy as well as historical and philosophical reconstruction. The article focuses on the interpretation of man in young Nietzsche’s philosophy and compares it with the ideas in his later works. The paper argues that his doctrine of the overman is preceded by the idea of considering man within the framework of such concepts as proto-man, total man, total artist and tragic man. Apparently, early Nietzsche’s philosophical and anthropological views were conditioned by two contexts: ancient philosophy and culture of the pre-Socratic period (“the tragic era”) on the one hand, and A. Schopenhauer’s metaphysics and the aesthetics in R. Wagner’s works on the other. The article substantiates the thesis that the determining factors in the genesis of young Nietzsche’s ideas were the assimilation and rethinking of Schopenhauer’s and Wagner’s views. Schopenhauer’s metaphysics and Wagner’s aesthetics act as the starting point and a conceptual horizon for the reception of the “tragic era” of antiquity, not vice versa. In addition, the paper emphasizes that to understand the crisis of European metaphysics Nietzsche turned to the philosophical reception of antiquity. A parallel is drawn between Nietzsche’s interpretations of the crisis of ancient culture and the crisis of modern Christian culture.
Mekanisme Penetapan Harga Jual dalam Tinjauan Ekonomi Islam Terhadap Usaha Toko Serba 35 Fauzi Collection Sintang
Authors: Melja Pusarti  , Tehedi  , Deni Irawan
Published: October 2024

This research departs from the phenomenon of pricing carried out by the fauzi collection shop in Sintang which sets a selling price of 35 thousand. This shop is experiencing very rapid development. The existence of this shop has a very good impact so that it can be felt by the middle to lower economic community. Thus, this journal has a research focus, namely: (1) How is the mechanism for determining the selling price at the Sintag collection fauzi shop? (2) How is the Islamic economic review of the mechanism for determining the selling price? (3) What is the impact of setting the selling price. This research uses a qualitative descriptive analytical approach and type of field study research. Data collection techniques through interviews, observation and documentation. Data analysis includes data reduction, data display, and verification / conclusion drawing. The results of the discussion show that the mechanism for determining the selling price at the all-round shop 35 fauzi collection Sintang is based on capital, employee wages, rental space, electricity costs, and distribution costs. In setting prices, there are six procedures carried out by the all-round shop 35 fauzi collection Sintang, namely choosing objectives in pricing, determining demand, estimating costs, analyzing costs, prices and competitor offers, choosing pricing methods, setting the final price. The type of strategy used is competition  based pricing / competitive pricing strategy. The Islamic economic review of the selling price setting mechanism carried out by the owner of the all-round shop 35 fauzi collection Sintang is in accordance with Islamic economics, prices do not harm sellers and buyers. The price is in accordance with the benefits of the goods provided. The impact of pricing carried out by the owner of the all-round shop 35 fauzi collection Sintang is a positive impact that can be felt by the middle to lower class people.
Sistem Informasi Pemesanan Dan Transaksi Jasa Pangkas Rambut Pada Ndasmu Barbershop Berbasis Website
Authors: SURYADIN IMAM TRI
Published: October 2024

Saat ini, keberadaan teknologi informasi telah dapat dirasakan dampaknya hampir di setiap sektor kehidupan manusia. Dengan berbagai kemudahan yang disajikan, tidak serta merta membuat tegnologi informasi menjadi hal yang dapat dinikmati semua pihak. Digitalisasi telah lama menjadi gaya hidup yang diadopsi oleh semua kalangan, tidak terkecuali bagi kelompok pelaku usaha. Peran teknologi informasi telah banyak mengubah cara pandang dan aktivitas bisnis saat ini. Teknologi informasi dimaksudkan sebagai jalan keluar untuk strategi kemajuan bisnis. Ndasmu Barbershop merupakan waralaba Barbershop terpercaya dan sangat kompeten dalam bidang pelatihan dan jasawaralaba. Serta sistem Management Barber yang Tersistem, memiliki lembaga trainning center sendiri, marketing plan yang Bagus serta tenaga SDM yang Terlatih dan expert. Ndasmu Barbershop adalah Pusat Pelatihan SDM, waralaba barbershop, barbertools Shop, Barberman yang expert dalam bidang pangkas rambut di Indonesia. Ndasmu Barbershop pusat beralamat di Jl. Pramuka No.21, Kepatihan, Sebelah Barat Prapatan Kembang, Kec. Purworejo, Kabupaten Purworejo, Jawa Tengah 54151.
Impulsando el crecimiento y el fortalecimiento de la Revista Peruana de Ciencias de la Salud
Authors: Ruiz-Aquino Mely
Published: October 2024

La Revista Peruana de Ciencias de la Salud (RPCS) es una publicación editada por el Vicerrectorado de Investigación de la Universidad de Huánuco, ubicada en Huánuco, Perú. La RPCS está encaminada a la difusión de conocimientos en las ciencias de la salud, incluyendo disciplinas como la medicina básica y clínica, así como la salud pública. Su principal objetivo es divulgar el conocimiento científico a través de la presentación de resultados originales, como producto de investigaciones que representen una contribución significativa al desarrollo en el campo de la salud. Además, la Revista busca fomentar la cooperación científica, con el propósito de asegurar que el conocimiento generado sea conocido y ampliamente difundido.
Thirty Years Later, or The Biological Approach to Competition Revisited
Authors:   Financial University under the Government of the Russian Federation, Yudanov Andrey Yu.
Published: October 2024

The article discusses the effectiveness of the biological approach of generic strategies of competition by L. G. Ramensky – J. P. Grime to economic processes. Four main strategies are considered: violent, patient, commutant, and explorant. The competitive advantages of firms adhering to these strategies, as well as interactions within the population of firms adhering to different strategies as a single system are considered. The main methodological technique used in the article is to compare the competitive situation in Russia thirty years ago, i. e. at the dawn of the development of market relations in the country, with what is happening now. The main changes that have occurred with firms adhering to each of the four generic strategies are characterized. It is argued that an important reason of the recent high resistance of the Russian economy to external shocks that came as a surprise to most economists is connected with the high adaptability of the system of competitive relations that has developed in the country.
Secuelas Neuromusculoesqueléticas Derivadas del Tratamiento en Pacientes Oncológicos
Authors: Abril Mera Tania María , Cedeño Holguín Doménica Elizabeth , Castello Martínez Paola Isabella , Holguín Jimenez Martha Lorena
Published: October 2024

Introducción: Las lesiones neuromusculoesqueléticas inducidas por el tratamiento del cáncer son un problema complejo que requiere un enfoque preventivo y de manejo integral. La identificación temprana, la evaluación adecuada y la intervención oportuna son esenciales para minimizar el impacto de estas lesiones en la calidad de vida de los pacientes con cáncer. Objetivo: Analizar la prevalencia de las secuelas neuromusculoesqueléticas en pacientes oncológicos que recibieron fisioterapia en el Hospital General SOLCA, durante el periodo 2023. Metodología: Este estudio es descriptivo, retrospectivo de corte transversal con un enfoque cuantitativo. El universo poblacional de pacientes que fue de 300, con la aplicación de criterios de inclusión y exclusión, se redujo una muestra a 207 pacientes. Resultados: Predominó el sexo femenino con el el 80.67% y el rango de edad con mayor incidencia fue de 50 a 59 años. Siendo el Carcinoma con mayor prevalencia con el 80.04% en el grupo de estudio; Predominó como tratamiento oncológico la combinación de cirugia, quimioterapia y radioterapia con el 71.01%, presentando como secuelas linfedema, limitacion en miembro superior y dolor con el 47.34%. Conclusión: Se evidenció una alta prevalencia de secuelas neuromusculoesqueléticas en relación con el tratamiento oncológico y el tipo de cáncer, afectando la calidad de vida de los pacientes, presentando: dolor, linfedemas, limitación articular y debilidad muscular. Estos hallazgos resaltan la importancia de la prevención e intervención fisioterapéutica la cual ayudará a los pacientes a superar desafíos oncológicos, obtener independencia y resiliencia, lo que es fundamental para una mejor calidad de vida.
La Capacidad de Acción, Culpabilidad, y el Fin de la Pena en la Determinación de la Responsabilidad Penal de las Personas Jurídicas
Authors: Silva Castro Blanca Marina
Published: October 2024

La investigación plantea como objetivo general analizar las categorías dogmáticas de la capacidad de acción, la culpabilidad, los fines de la pena y su relación en la determinación de la responsabilidad penal en las organizaciones colectivas para tal fin se han abordado algunos conceptos y teorías relacionadas al tema investigado considerando que el derecho penal convencional sólo las considera destinatarias a las personas naturales. En la ejecución del tema investigado se ha utilizado el enfoque cualitativo para desarrollar un análisis reflexivo y crítico  de las  categorías relacionadas a la imputación penal de la persona jurídica. Los resultados de la investigación demuestran como hallazgos lo siguiente: la persona jurídica cuenta con capacidad de acción mediante los actos que ejecutan los órganos de acuerdo a lo regulado en los estatutos y normas internas de organización, asumen culpabilidad autónoma cuando no cuenta con una adecuada organización por existir un defecto en su constitución y el fin de la pena se centra en restablecer la vigencia de las normas lesionadas mediante la imposición de sanciones penales.
PENERAPAN ARSITEKTUR EKOLOGI PADA PENATAAN KAWASAN PERMUKIMAN BANTARAN SUNGAI DI KELURAHAN TALUMOLO KOTA GORONTALO
Authors: Pade Nur Rahmathia Auliyah , Tatura Lydia Surijani , Idji Berni
Published: October 2024

The residential area in the Talumolo Village, which is on the banks of the Bone River, is one of the slum areas in Gorontalo city. This region is a result of an uncontrolled increase in settlements. As a result, there are many semi-permanent housing units in medium-density settlement conditions with minimal accessibility and areas that are highly vulnerable to disasters, as well as residential neighborhoods that are dense, irregular, and lack the availability of environmental facilities and infrastructure that meet technical and health standards, and no proper. Based on the study rationale, thus, a strategy is needed that is able to handle density in the riverbank settlement environment. The problems obtained were then analyzed to produce a design concept with the theme of Ecological Architecture.Ecological Architecture, this architectural concept usually settles more in harmony with nature for buildings by maximizing lighting, air circulation, building materials selection, and rainwater utilization to be in harmony with nature. The ecological concept is the concept of environmental management by utilizing the potential or natural resources and technology utilization based on environmentally friendly ethical management. As the design result, it can organize settlements with all activities and marketing facilities that promote the people in the riverbanks, Talumolo Village, Gorontalo City. Kawasan permukiman di Kelurahan Talumolo yang berada dibantaran sungai bone ini adalah salah satu kawasan permukiman kumuh yang berada di kota Gorontalo. Daerah ini juga merukapan akibat pertambahan permukiman yang tak terkendali. Akibatnya muncul lingkungan perumahan yang padat,tidak teratur, dan tidak memiliki ketersediaan sarana dan prasarana lingkungan yang memenuhi standar teknis dan kesehatan, kondisi permukiman kepadatan sedang dengan unit hunian yang cukup banyak yang semi permanent, ketersediaan aksesibilitas yang minim, dan daerah dimana sangat rawan bencana, namun tidak memiliki jalur evakuasi yang layak sesuai peraturan. Merujuk pada permasalahan permukiman yang terjadi, maka diperlukan strategi yang mampu mengurangi atau bahkan menghilangkan kepadatan pada lingkungan permukiman bantaran sungai. Dari permasalahan yang diperoleh selanjutnya dianalisis sehingga menghasilkan konsep perancangan dengan tema Arsitektur Ekologi. Arsitektur Ekologi, konsep arsitektur ini biasanya lebih mengedepankan keselarasan dengan alam untuk bangunan dengan memaksimalkan pencahayaan, sirkulasi udara, pemilihan material bangunan dan pemandaatan air hujan untuk menjadi harmonis dengan alam. Konsep ekologis merupakan konsep penataan lingkungan dengan memanfaatkan potensi atau sumberdaya alam dan penggunaan teknologi berdasarkan manajemen etis yang ramah lingkungan. Sebagai hasil desain yaitu dapat menata permukiman dengan segala kegiatan dan sarana pasarana yang mendukung terhadap masyarakat bantaran sungai Kelurahan Talumolo Kota Gorontalo.
PENERAPAN ARSITEKTUR MODERN PADA PERANCANGAN SIRKUIT BALAP MOTOR NASIONAL DI GORONTALO
Authors: Podungge Moh Reza , Trumansyahjaya Kalih , Tatura Lydia Surijani
Published: October 2024

A circuit is an enclosed space far from regular traffic and human activities. The circuit comprises permanent and temporary structures, with a track for motorcycle racing that goes from the starting line to the finish line at the same point designed for motorcycle racing events. The circuit will serve as a place to nurture the community's interests and talents in the automotive field. Gorontalo province possesses a strong interest in automotive sports, which is proven by the existence of 21 motorcycle communities divided into hobbies and achievements. Motorcycle racing events in Gorontalo are typically held at the Sang Profesor Circuit in Kota Limboto and several districts across the province. However, the facilities at these circuits are minimal, providing only tracks, and access to the circuit is also limited due to inadequate infrastructure. This circuit will also be designed using modern architectural theories while following the national and international circuit standards set by the Ikatan (IMI), Federation Internationale de Motocylisme (FIM), and Federation Internationale de'Automobile (FIA). "This study's objective was to provide a circuit facility that meets both national and international standards, following the regulations set by the Ikatan (IMI), Federation Internationale de Motocylisme (FIM), and Federation Internationale de'Automobile (FIA). Sirkuit adalah suatu tempat tertutup dimana jauh dari kendaraan umum dan aktivitas manusia sirkuit itu sendiri memiliki bangunan permanen dan tidak permanen, sirkuit memiliki lintasan yang dimulai dari garis start ke garis finish pada titik yang sama yang di khususkan untuk ajang balap sepeda motor. Sirkuit akan menjadi tempat untuk menampung hobi dan bakat masyarakat dalam bidang otomotif. Mengingat Provinsi Gorontalo peminat olahraga otomotif sudah cukup meluas dengan adanya komunitas-komunitas motor yang berbasis di Provinsi Gorontalo yaitu sebanyak 21 komunitas motor yang terbagi atas hobi dan prestasi. Event balap motor di Gorontalo biasanya diadakan di Sirkuit Sang Profesor yang berada di Kota Limboto dan dibeberapa kabupaten yang berada di Provinsi Gorontalo. Namun fasilitas-fasilitas di sirkuit tersebut masih sangat minim yang hanya menyediakan jalur lintasan saja dan akses menuju sirkuit tersebut masih kurang baik. Sirkuit ini juga akan di rancang dengan menggunakan teori-teori arsitektur modern, serta tidak menyampingkan aturan-aturan standar sirkuit nasional maupun internasional yang telah di tetapkan oleh Ikatan Motor Indonesia (IMI), Federation Internationale de Motocylisme (FIM) dan Federation Internationale de’Automobile (FIA). Tujuan dari penelitian ini menyediakan fasilitas-fasilitas sirkuit berstandar nasional maupun internasional menurut aturan-aturan Ikatan Motor Indonesia (IMI), Federation Internationale de Motocylisme (FIM) dan Federation Internationale de’Automobile (FIA).
KONSEP BIOPHILIC ARCHITECTURE SEBAGAI PENDEKATAN PADA AL-QUR’AN CENTER DI GORONTALO
Authors: Nurmuhammad Andi Annisa , Heryati Heryati , Pratiwi Niniek
Published: October 2024

Gorontalo regency is a city that possess a majority of Muslim population with a percentage of 98%. However, as times and technology have changed, many Muslims in Gorontalo have started to be influenced by foreign cultures that diverge greatly from Islamic teachings. The Gorontalo Muslim community in the globalization era must also face even more difficult challenges due to the intrussion of a culture of hedonizm, materializm and secularizm into human life. Thus, in order to meet this challenge, The Gorontalo Muslim community must increase their knowledge of their religion, specifically by reading the Qur’an and it also hoped that they will be able to resolve the widespread spiritual crisis that is presently plaguing them. For this reason, a forum is required that can emerge and revive the role of the Qur’an as a guideline for Muslim life, namely by building an Al-Qur’an Center in Gorontalo which prepares all facilities for Islamic activities based on the Qur’an and Hadith.The method used in the design and planning of Al-Qur’an Center is data collection,  which is the first step to collect factual issues that become the background of the title selection then obtain data through observation, which is by collecting data directly from the research site, interview method and literature study method, namely studying, understanding, literatureand searching for sources related to the research object. The design of Al-Qur’an Center is anticipated to be the best effort to overcome the current spiritual crisis in Gorontalo. By emphasizing the concept of Biophilic Architecture, this design will foster a positive relationship between humans and nature with Architecture, this design will foster a positive relationship between humans and nature with architecture. Biophilic design seeks to produce a space that can participate in improving the physical and mental well-being of human life.
STUDY OF BEHAVIOURAL ADAPTATION AGAINST CHANGES TO THE LAYOUT OF THE OFFICE WORKSPACE AT COVID-19 PANDEMIC PERIOD
Authors: Suharto Moh. Fachruddin , Zuldesmi Zuldesmi , Attaufiq Muhammad Muhdi , Kawatu Freike Eugene
Published: October 2024

The Covid-19 pandemic has caused many changes to human lifestyles, one of which is changing the way we work and the way we define the 'workplace' which is known as the office. As a result of this phenomenon, there is an adaptation of user behaviour (office employees) to changes in the layout of the workspaces in their offices. This research provides an overview of the adaptation to changes in the layout of the workspace and changes in employee behaviour in their workplace during the Covid-19 pandemic. The adaptation applied is the Adaptation to New Habits (ANH) as a realization of the implementation of health protocols that have been set by the government. In this study, employees' perceptions will be measured based on physiological factors in the form of sources of information they get to implement the adaptation to new habits and how this encourages them to implement health protocols during the Covid-19 pandemic. The research method used is a qualitative description which is then quantified to determine the tendency of office employees to adapt  to changes in the layout of office workspace. In addition, it also seeks to understand, examine and interpret the meaning of an adaptation event and changes in human behaviour toward changes in workspace layout in the Covid-19 pandemic situation from the perspective of the researchers themselves. The results of this study reveal that in the adaptation process there are changes due to essential needs related to health protocol procedures in the office and space requirements that are adapted to their functions.
CAMPURAN SEKAM PADI DAN SERBUK GERGAJI SEBAGAI BAHAN INSULASI PADA KONSTRUKSI RUMAH MINAHASA
Authors: Gosal Pierre Holy , Sondakh Julianus
Published: October 2024

The Minahasa Stilt House is well known not only in Minahasa but throughout Indonesia and even abroad. The main problem with this stilt house is that the house is not designed to meet the occupants' thermal comfort as per SNI T-14-1993-03. The walls, floors and ceilings of stilt houses are made from planks with a thickness of 3 cm to 4 cm. It is suspected that with such a thickness, heat transfer to walls, floors and ceilings can occur quickly. An indoor AC system for room comfort will result in a waste of energy because the cooling load tends to be high. In this research, several materials that are locally available in Minahasa will be examined, namely sawdust and rice husks, which have the potential to be used as insulation. The method that will be used in this research is quantitative-descriptive. The aim of the research is to obtain local materials that can be used as insulation for the building envelope of stilt houses. This Husk Powder Insulation can be used as insulation material for Minahasa wooden houses on stilts. Rumah Panggung Minahasa sudah cukup dikenal tidak hanya di Minahasa tetapi diseluruh Indonesia bahkan sampai diluar negeri. Permasalahan utama dari rumah panggung ini adalah  rumah tidak dirancang untuk memenuhi kenyamanan termal penghuni sebagaimana SNI T-14-1993-03. Dinding, lantai, dan plafond rumah panggung dibuat dari bahan papan dengan ketebalan  3 Cm s/d 4 Cm. Diduga bahwa dengan ketebalan seperti itu, perpindahan panas pada dinding, lantai, dan platfond dapat terjadi dengan cepat. Sistem AC didalam ruangan untuk kenyamanan ruangan, akan mengakibatkan pemborosan energi karena beban pendinginan cenderung tinggi.  Dalam penelitian ini akan diteliti beberapa bahan yang tersedia secara lokal di Minahasa yaitu serbuk gergaji dan sekam padi, berpotensi sebagai insulasi.Metode yang akan digunakan pada penelitian ini adalah kwantitatif-deskriptif. Tujuan penelitian adalah memperoleh bahan-bahan lokal yang dapat dijadikan insulasi selubung bangunan rumah panggung. Insulasi Serbuk-Sekam ini dapat digunakan sebagai bahan insulasi rumah kayu panggung Minahasa.
A Mesh Convergence Study for 2D Axisymmetric Pipe Wall Thickness
Authors: Eliza M. Yusup  , Haqeemy Azahari  , Shahzulreza Saiful  , Faisal Mansor  , Mohamad Nur Hidayat Mat  , Balasem Abdulameer Jabbar
Published: October 2024

A meshing size study is essential for any simulation, as it affects the accuracy of the results by approximating the real-world geometry. This paper presents a detailed mesh convergence study for a 2D axisymmetric pipe model. The model incorporates a one-quarter cross-section due to the axisymmetric nature of the pipe. Four pipe wall thicknesses were investigated: 3.40 mm, 7.11 mm, 10.97 mm, and 18.26 mm. The results revealed a significant advantage for simulations involving thin pipes. They achieved convergence, a state with stable solution values, by utilizing a less dense mesh, leading to reduced computational time. This trend was exemplified by the fact that a thinner pipe with thickness, t = 3.40 mm has converged with only 8 mesh elements, whereas a significantly thicker pipe, t = 18.26 mm necessitated 14 elements for convergence. This suggests that more complex geometries, with intricate details, may require a larger and denser mesh for convergence, leading to increased computational time. In conclusion, the mesh convergence study confirms that the finite element analysis (FEA) model has achieved a converged solution.
Membangun Kinerja Unggul: Peran Budaya dan Komitmen Organisasi di Kantor Imigrasi Kelas I Khusus TPI Surabaya
Authors: Habbi Firlana  , Hanin Jauza Rahman
Published: October 2024

Penelitian ini bertujuan untuk menganalisis pengaruh simultan antara budaya organisasi dan komitmen organisasi terhadap kinerja pegawai di Kantor Imigrasi Kelas I Khusus TPI Surabaya, serta memahami bagaimana persepsi pegawai terhadap budaya dan komitmen organisasi berkontribusi terhadap kinerja mereka. Metode yang digunakan adalah mix method sequential explanatory, yang menggabungkan pendekatan kuantitatif melalui survei terhadap 152 pegawai dan kualitatif melalui wawancara semi-terstruktur. Hasil penelitian menunjukkan bahwa budaya organisasi dan komitmen organisasi secara simultan berpengaruh signifikan terhadap kinerja pegawai, dengan kontribusi sebesar 87,2%. Secara parsial, budaya organisasi yang kuat, terutama pada aspek keterlibatan pegawai dan adaptabilitas, memiliki pengaruh positif terhadap peningkatan kinerja. Pegawai dengan komitmen afektif menunjukkan kinerja yang lebih tinggi, sedangkan pegawai dengan komitmen kelanjutan cenderung memiliki kinerja yang lebih rendah. Temuan ini diperkuat oleh wawasan kualitatif, di mana pegawai yang merasakan keterlibatan dalam pengambilan keputusan dan memiliki keterikatan emosional dengan organisasi menunjukkan motivasi dan kinerja yang lebih baik. Kesimpulannya, penguatan budaya organisasi dan peningkatan komitmen afektif menjadi strategi penting dalam meningkatkan kinerja pegawai.
Climatic Characteristics of Algeria and Building Materials of Office Buildings of the Colonial Period
Authors: Alia Hassina , Belakehal Azedinne , Slama Imène , Mezerdi Toufik
Published: October 2024

This research presents a classification of office buildings during the colonial period by adopting a bibliographic and monographic approach. This classification has two objectives: the first is to identify the typologies of building materials used in each climate zone of Algeria; the second objective consists of an evaluation of the choices of these materials according to the respect or not of the climatic characteristics of the construction site. The analysis of these data will allow us to verify and understand one of the climate strategies adopted by French architects in order to adapt the building to the climate.
Sudden cardiac death due to adrenal insufficiency masquerading as Brugada syndrome. Case report
Authors: Kijvatova N. V. , Chumachenko N. V. , Golovina G. A. , Gordeeva H. V. , Kosmacheva H. D.
Published: October 2024

Sudden cardiac death in young people in 20% of cases is caused by cardiomyopathies and channelopathies. One of the forms of channelopathies is Brugada syndrome, a hereditary disease characterized by ST segment elevation in the right precordial leads (V1-V3) and an increased risk of sudden cardiac death in the absence of structural heart disease. Brugada phenocopies are also known – clinical situations that are manifested by electrocardiogram (ECG) patterns identical to true Brugada syndrome. They are caused by different clinical circumstances and form a group of heterogeneous conditions that are often difficult to distinguish from true congenital Brugada syndrome due to identical ECG patterns. The formation of Brugada phenocopy due to hyperkalemia is presented in the literature in various conditions: with renal failure, after extensive trauma, application of medications. The article presents a case report demonstrating a rare cause of sudden cardiac arrest in a young patient without a history of cardiovascular pathology: the occurrence of the Brugada pattern on the ECG due to severe hyperkalemia in adrenal insufficiency. The stages of the differential diagnostic search are described, which made it possible to verify the final diagnosis and prescribe effective hormone replacement therapy. Performing a provocative test with novocanamide allowed us to confirm that the patient had a phenocopy, and not Brugada syndrome. Differential diagnosis of phenocopies of Brugada syndrome – a series of often life-threatening cardiac and non-cardiac diseases and conditions, manifested by similar ECG changes in the form of a peculiar ST segment elevation in leads V1-V3, is often a difficult task. This case represents a phenocopy of Brugada in the setting of severe hyperkalemia with development of cardiac arrest due to adrenal insufficiency, which resolved with correction of electrolyte abnormalities and treatment of the underlying disease. Typical ECGs are presented: a graph of the Brugada phenomenon, hyperkalemia, a sinusoidal curve during cardiac arrest, recorded over time in a patient, and the pathogenetic mechanisms causing the formation of the Brugada pattern in adrenal insufficiency are explained.
Advances in Nanotechnology-Enhanced Delivery Systems of Geraniol: A Promising Future in Cancer Therapeutics
Authors: Das Chaudhuri Angsuman , Majumder Anirban , Manna Sounik
Published: October 2024

Geraniol, a naturally occurring monoterpenoid found in essential oils of several aromatic plants, exhibits numerous therapeutic properties, including anti-inflammatory, antimicrobial, and anticancer activities. However, its therapeutic potential is hindered by poor water solubility, limited bioavailability, and rapid metabolism. Nanotechnology- based delivery systems offer a promising solution to these challenges, by enhancing the solubility, stability, and bioavailability of geraniol through advanced delivery systems in cancer treatment. This review critically examines recent advances in nanotechnology- based delivery systems for geraniol, exploring various nanocarriers such as liposomes, polymeric nanoparticles, dendrimers, and solid lipid nanoparticles. The review also highlights the mechanisms by which these nanocarriers improve geraniol's pharmacokinetic profile, its targeted delivery to cancer cells, and its impact on overcoming multidrug resistance. Future perspectives and potential clinical applications are discussed, emphasizing the need for further research to fully harness the potential of geraniol in cancer therapy.
Evaluating Curcumin and Bromelain as Dentin Biomodifiers for Enhancing Shear Bond Strength – An Invitro study
Authors: Puthur Aju Anto , Nayak Moksha , B Rohini , Gopal G. Gagan
Published: October 2024

Aim To evaluate the effect of collagen stabilizing agents like Curcumin and Bromelain enzyme on the shear bond strength of restorative resin to dentin.  Materials and Methods Thirty single rooted, non carious human mandibular premolars were selected and decoronation was done. The tooth was then mounted. Etchant was applied to the dentin samples and divided into 3 experimental groups. Group 1 (Control - Bonding agent + Composite); Group 2 (Pre-treatment with Curcumin for 30 sec + Rinsing + Bonding agent + Composite). Group 3(Pre-treatment with Bromelain enzyme for 30 sec + Rinsing + Bonding agent + Composite). Following this, total etch adhesive was applied and light. Nanohybrid composite restoration was done. Then the samples were subjected to shear bond strength. The load was applied to the bonded interface with a cross-head speed of 0.5 mm / minute until fracture occurred.  Results The mean values Shear bond strength of dentin were slightly more in bromelain enzyme (48.49), seconded by curcumin (38.80), followed by control group (27.23). The difference was statistically significant among the three different remineralising agent used.  Conclusion Bromelain enzyme showed the highest mean shear bond strength value when compared to the other experimental group.
Comparison of maternal circulating collectrin levels between normal pregnancies and pregnancies complicated by oligohydramnios and fetal growth restriction
Authors: Ceyhan Meryem , Hançerlioğulları Necati , Yaman Selen , Erol Koç Esin Merve , Çandar Tuba , Tokmak Aytekin
Published: October 2024

Objective: Collectrin is a transmembrane regulatory glycoprotein involved in the renin-angiotensin system and plays an important role in kidney development. It is well known that placental perfusion play essential role in maintaining amniotic fluid production and fetal development. The current study sought to assess the relationship between serum collectrin levels and fetal growth restriction (FGR) and oligohydramnios.
Methods: This observational study was done in a tertiary level maternity hospital. The study groups were comprised of pregnancies complicated with term oligohydramniosis and isolated FGR. The control group was selected from among low risk healthy pregnancies. Demographic features, obstetric characteristics, gestational age, amniotic fluid index, fetal biometric measurements, doppler indices, blood pressure, pulse, hematologic, and biochemical parameters, and serum collectrin levels were recorded for each patient.
Results: No significant differences were observed among the groups with regard to maternal age, body mass index, gesational week, and peripheral blood pressures (p>0.05). The birth weights were statistically significantly lower in the FGR group than the other 2 groups (p
Gondolatok a helyszíni krimináltechnika egyes elméleti és gyakorlati kérdéseiről
Authors: Petrétei Dávid
Published: October 2024

The author provides an overview of technical and theoretical dilemmas, mostly concerning indirect proof, probability calculations and the use of modern technology within crime scene investigation, and in general, in the field of forensic sciences.
A poligráf ítélkezési jelentőségének dilemmái
Authors: Fedor Anett
Published: October 2024

The author provides an overview of the debate that concerns the judicial acceptance of evidence extracted by polygraph technology during the investigation process.
Rendőrnők pályaválasztási motivációinak vizsgálata
Authors: Kardos Sándor
Published: October 2024

The author provides on overview of a Hungarian research survey focusing on female police officers’ view on their career.
A hónap eseményei az EU belügyi együttműködése terén (július-augusztus)
Authors: Szabó Adrienn
Published: October 2024

The author summarises the events of July-August 2013 in the field of EU cooperation on home affairs.
A községi rendőrségek a vidék rendvédelmében
Authors: Ernyes Mihály
Published: October 2024

The author provides an overview of the history of municipal police in Hungary from the late 19th century till the end of WWII.
A Multiwavelength Approach to Constraining the Merger Properties of ACT-CL J0034.4+0225
Authors: Doze Peter , Hilton Matt , Hughes John P. , Keeton Charles R. , Knowles Kenda , Moodley Kavilan , Mroczkowski Tony , Partridge Bruce , Raney Catie A. , Sifón Cristóbal , Sikhosana Sinenhlanhla , Vargas Cristian , Wollack Edward J.
Published: October 2024

ACT-CL J0034.4+0225 is a previously unrecognized merging galaxy cluster at z = 0.38588 ± 0.00068. Our primary evidence is provided by a 21 ks Chandra image that shows two surface brightness peaks separated by ∼49″ (259 kpc) surrounded by an extended cluster gas distribution. Each gas peak contains a brightest cluster galaxy, offset from the gas peak. We collect new South African Large Telescope optical spectra that, when augmented by archival data, yield redshifts for the two BGCs and 58 other cluster members. Archival Giant Metrewave Radio Telescope and MeerKAT data reveal a radio halo that encompasses the X-ray peaks. We provide and compare three X-ray-based mass estimates (5.0 × 1014
M
⊙, 6.4 × 1014
M
⊙, and 8.6 × 1014
M
⊙). The Planck and ACT Sunyaev–Zel’dovich masses are ≈5.8 × 1014
M
⊙. We constrain the merger state and properties by comparing them to an existing suite of N-body/hydrodynamical models using the measured gas peak separation (259 kpc, projected) and radial velocity difference (0–1000 km s−1). This constrains the epoch of the merger to be within ∼100 Myr of first pericenter passage. A strong lensing analysis constrains the mass ratio to be in the range 1:1–1:20, while the cluster morphology prefers values near the equal-mass range.
A Census from JWST of Extreme Emission-line Galaxies Spanning the Epoch of Reionization in CEERS
Authors: Davis Kelcey , Trump Jonathan R. , Simons Raymond C. , McGrath Elizabeth J. , Wilkins Stephen M. , Arrabal Haro Pablo , Bagley Micaela B. , Dickinson Mark , Fernández Vital , Amorín Ricardo O. , Backhaus Bren E. , Cleri Nikko J. , Llerena Mario , Brunker Samantha W. , Barro Guillermo , Bisigello Laura , Brooks Madisyn , Costantin Luca , de la Vega Alexander , Dekel Avishai , Finkelstein Steven L. , Hathi Nimish P. , Hirschmann Michaela , Kartaltepe Jeyhan S. , Koekemoer Anton M. , Lucas Ray A. , Papovich Casey , Pérez-González Pablo G. , Pirzkal Nor , Rodighiero Giulia , Rose Caitlin , Yung L. Y. Aaron ,   CEERS Collaborators
Published: October 2024

We present a sample of 1165 extreme emission-line galaxies (EELGs) at 4 < z < 9 selected using James Webb Space Telescope (JWST) NIRCam photometry in the Cosmic Evolution Early Release Science (CEERS) program. We use a simple method to photometrically identify EELGs with Hβ + [O iii] (combined) or Hα emission of observed-frame equivalent width (EW) > 5000 Å. JWST/NIRSpec spectroscopic observations of a subset (34) of the photometrically selected EELGs validate our selection method: All spectroscopically observed EELGs confirm our photometric identification of extreme emission, including some cases where the spectral-energy-distribution-derived photometric redshifts are incorrect. We find that the medium-band F410M filter in CEERS is particularly efficient at identifying EELGs, both in terms of including emission lines in the filter and in correctly identifying the continuum between Hβ + [O iii] and Hα in the neighboring broadband filters. We present examples of EELGs that could be incorrectly classified as ultrahigh redshift (z > 12) as a result of extreme Hβ + [O iii] emission blended across the reddest photometric filters. We compare the EELGs to the broader (subextreme) galaxy population in the same redshift range and find that they are consistent with being the bluer, high-EW tail of a broader population of emission-line galaxies. The highest-EW EELGs tend to have more compact emission-line sizes than continuum sizes, suggesting that active galactic nuclei are responsible for at least some of the most extreme EELGs. The photometrically inferred emission-line ratios are consistent with interstellar medium conditions with high ionization and moderately low metallicity, consistent with previous spectroscopic studies.
Identification of High-redshift Galaxy Overdensities in GOODS-N and GOODS-S
Authors: Helton Jakob M. , Sun Fengwu , Woodrum Charity , Hainline Kevin N. , Willmer Christopher N. A. , Rieke Marcia J. , Rieke George H. , Alberts Stacey , Eisenstein Daniel J. , Tacchella Sandro , Robertson Brant , Johnson Benjamin D. , Baker William M. , Bhatawdekar Rachana , Bunker Andrew J. , Chen Zuyi , Egami Eiichi , Ji Zhiyuan , Maiolino Roberto , Willott Chris , Witstok Joris
Published: October 2024

We conduct a systematic search for high-redshift galaxy overdensities at 4.9 < z
spec < 8.9 in both the Great Observatories Origins Deep Survey (GOODS)-N and GOODS-S fields using James Webb Space Telescope/Near-Infrared Camera (JWST/NIRCam) imaging from the JWST Advanced Deep Extragalactic Survey and JWST Extragalactic Medium-band Survey in addition to JWST/NIRCam wide field slitless spectroscopy from the First Reionization Epoch Spectroscopic Complete Survey. High-redshift galaxy candidates are identified using Hubble Space Telescope + JWST photometry spanning λ = 0.4–5.0 μm. We confirmed the redshifts for roughly a third of these galaxies using JWST spectroscopy over λ = 3.9–5.0 μm through identification of either Hα or

OIII

λ
5008

around the best-fit photometric redshift. The rest-ultraviolet magnitudes and continuum slopes of these galaxies were inferred from the photometry: the brightest and reddest objects appear in more dense environments and thus are surrounded by more galaxy neighbors than their fainter and bluer counterparts, suggesting accelerated galaxy evolution within overdense environments. We find 17 significant (δ
gal ≥ 3.04, N
gal ≥ 4) galaxy overdensities across both fields (seven in GOODS-N and 10 in GOODS-S), including the two highest redshift spectroscopically confirmed galaxy overdensities to date at

z
spec

=
7.954

and

z
spec

=
8.222

(representing densities around ∼6 and ∼12 times that of a random volume). We estimate the total halo mass of these large-scale structures to be

11.5
≤

log

10

M

halo

/

M

⊙

≤
13.4

using an empirical stellar mass-to-halo mass relation, which are likely underestimates as a result of incompleteness. These protocluster candidates are expected to evolve into massive galaxy clusters with

log

10

M

halo

/

M

⊙

≳
14

by z = 0.
A Gamma-Ray Flare from TXS 1508+572: Characterizing the Jet of a z = 4.31 Blazar in the Early Universe
Authors: Gokus Andrea , Böttcher Markus , Errando Manel , Kreter Michael , Heßdörfer Jonas , Eppel Florian , Kadler Matthias , Smith Paul S. , Benke Petra , Gurvits Leonid I. , Kraus Alex , Lisakov Mikhail , McBride Felicia , Ros Eduardo , Rösch Florian , Wilms Jörn
Published: October 2024

Blazars can be detected from very large distances due to their high luminosity. However, the detection of γ-ray emission of blazars beyond z = 3 has only been confirmed for a small number of sources. Such observations probe the growth of supermassive black holes close to the peak of star formation in the history of galaxy evolution. As a result from a continuous monitoring of a sample of 80 z > 3 blazars with the Fermi Large Area Telescope (Fermi-LAT), we present the first detection of a γ-ray flare from the z = 4.31 blazar TXS 1508+572. This source showed high γ-ray activity from 2022 February to August, reaching a peak luminosity comparable to the most luminous flares ever detected with Fermi-LAT. We conducted a multiwavelength observing campaign involving XMM-Newton, the Neil Gehrels Swift Observatory, the Effelsberg 100 m radio telescope, and the Very Long Baseline Array. In addition, we make use of the monitoring programs by the Zwicky Transient Facility and the Near-Earth Object Wide-field Infrared Survey Explorer at optical and infrared wavelengths, respectively. We find that the source is particularly variable in the infrared band on daily timescales. The spectral energy distribution collected during our campaign is well described by a one-zone leptonic model, with the γ-ray flare originating from an increase of external Compton emission as a result of a fresh injection of accelerated electrons.
Where Have All the Sulfur Atoms Gone? Polycyclic Aromatic Hydrocarbon as a Possible Sink for the Missing Sulfur in the Interstellar Medium. I. The C–S Band Strengths
Authors: Yang X. J. , Hua Lijun , Li Aigen
Published: October 2024

Despite its biogenic and astrochemical importance, sulfur (S), the 10th most abundant element in the interstellar medium (ISM) with a total abundance of S/H ≈ 2.2 × 10−5, largely remains undetected in molecular clouds. Even in the diffuse ISM where S was previously often believed to be fully in the gas phase, in recent years, observational evidence has suggested that S may also be appreciably depleted from the gas. What might be the dominant S reservoir in the ISM remains unknown. Solid sulfides like MgS, FeS, and SiS2 are excluded as major S reservoirs due to the nondetection of their expected infrared spectral bands in the ISM. In this work, we explore the potential role of sulfurated polycyclic aromatic hydrocarbon (PAH) molecules—PAHs with sulfur heterocycles (PASHs)—as a sink for the missing S. Utilizing density function theory, we compute the vibrational spectra of 18 representative PASH molecules. It is found that these molecules exhibit a prominent C–S stretching band at ∼10 μm and two relatively weak C–S deformation bands at 15 and 25 μm that are not mixed with the nominal PAH bands at 6.2, 7.7, 8.6, 11.3, and 12.7 μm. If several parts per million of S (relative to H) are locked up in PAHs, the 10 μm C–S band would be detectable by Spitzer and the James Webb Space Telescope (JWST). To quantitatively explore the amount of S/H depleted in PASHs, a detailed comparison of the infrared emission spectra of PASHs with the Spitzer and JWST observations is needed.