bluuebunny/crossref_metadata_2025 huggingface dataset:
Will narrowing the educational gap between husband and wife alleviate housework inequality: Evidence from China
Authors: Peng Zijian , Wu Lin
Published: October 2022

In the past 20 years, China’s educational advantage has undergone a gender reversal. The average educational level of women is higher than that of men. However, the gender difference in housework is gradually expanding, and women are still the main undertakers of housework. Based on the China Family Panel Studies, this study explores the impact of the educational gap between husband and wife on the inequality of housework division and its mechanism. OLS regression model was used to estimate the impact of marital education gap on household inequality. It is concluded that the higher the education level of the husband is than that of the wife, the greater the gender inequality in housework. This conclusion is significant at the level of 0.01. On this basis, the instrumental variable method was used to overcome the endogenous problems and a more accurate conclusion was reached. Every unit of increase in the education gap between husband and wife would increase the degree of household inequality by 0.281 percentage points. Quantile regression provides strong evidence for the results. When the gender time ratio of housework is in the range of 0.8–0.95, the education gap will have an impact on the gender division of housework. After the robustness test and heterogeneity analysis of the model, an intermediary variable was established to discuss the mechanism of the model. The income disparity and the working time gap were proved to be intermediary variables. This study believes that in modern society, the education gap between husband and wife will affect the inequality of housework division by changing the relative income and relative working time of husband and wife. Although the educational advantages of women in the whole society have not changed their role in the division of housework. However, with the narrowing of the educational gap between husband and wife, the degree of inequality in the division of housework has been alleviated, indicating that the improvement of women’s education level has alleviated the inequality in the division of housework to a certain extent.
The effect of similarity between owner’s values and their perceptions of their pet’s values on life satisfaction
Authors: Sneddon Joanne , Ye Sheng , Lee Julie A.
Published: October 2022

It is often assumed that pet ownership improves peoples’ wellbeing, but evidence of this pet effect has been mixed. We extended past research on pet personality, the pet effect, and value congruence to examine whether people perceive their pets to have humanlike values and if owner-pet values similarity has a positive effect on owners’ life satisfaction. In a large and diverse sample of Australian dog and cat owners, we find that people imbue their dogs and cats with humanlike values in a way that reflects the theoretical circular structure of values. Importantly, perceptions of the values of dogs and cats differed in that dogs were perceived to prioritize more social-focus values, whereas cats were perceived to prioritize more personal-focus values. Additionally, we find that similarity in the values profile of dog owners and their dogs is positively associated with life satisfaction, but this was not the case for cats. However, when we examined associations between individual values similarity and life satisfaction, our results suggest a more complex and nuanced picture of both direct and indirect similarity effects.
Using corpora to reveal style in translation: The case of The Song of Everlasting Sorrow
Authors: Meng Lingzi , Pan Feng
Published: October 2022

This article reports on a corpus-based study of the English translation of Wang Anyi’s award-winning novel, The Song of Everlasting Sorrow [长恨歌, Chang Hen Ge] from the perspective of style. Using the keyword and concordance functions of corpus software packages AntConc and ParaConc, this research focuses on how the translator’s style reveals itself in the target text (TT) as well as how the style of the source text (ST) is represented in the TT. Findings show that the translators have a preference for contracted negative verb forms and expressions such as “bit” over “little,” making the text more colloquial. In general, the rendering of the ST style tends not to be entirely faithful. A distinction between reader-centered and text-centered keywords is made. While the reader-centered ST keywords are, as expected, largely altered, the translation of text-centered ST keywords is also rewritten, contrary to expectations. Presumably, the translators tended to reduce the ambiguity of the ST, resulting in a more explicit TT. The article argues that the translators chose to rewrite the translation to make it more understandable for the target audience since it concerned a work from a source culture very different from the target culture.
Understanding the effect of organizational innovation environment and customer participation in virtual communities on customer creativity: A study of mediating and moderating influences
Authors: Ge Mina , Khan Jamal , Li Yuan
Published: October 2022

The importance of enterprises significantly improving their innovation performance by working closely with customers throughout the innovation process has been emphasized in recent literature. However, the role of organizational innovation environment in customer creativity and the impact of customer knowledge matching on the innovation environment are not sufficiently explored. Based on the Social cognitive theory and Flow theory, his investigate the factors that influence enterprise innovation performance in the context of customer participation in innovation, as well as how businesses can foster an online innovation environment that fosters customer creativity. The mixed-methods study, which combines qualitative and quantitative research, is used to create the scale item that measures the study’s main variables. Structural equation modeling and bootstrapping estimation was performed on survey data collected via questionnaire from 392 consumers who participated in online service innovation in an online virtual brand community between June 2018 and May 2019. The study obtain the following main results. First, the innovative environment of customer online participation in service innovation fosters customer creativity. Second, two mediation interactions exist: creative self-efficacy and positive emotions, both of which partially mediate the relationship between customer creativity and the innovation environment. Third, while customer knowledge matching influences the intermediary effect of creative self-efficacy on innovation environment and customer creativity, it has no effect on the intermediary effect of positive emotion on innovation environment and customer creativity.
How do aesthetics and tourist involvement influence cultural identity in heritage tourism? The mediating role of mental experience
Authors: Yang Wei , Chen Qiuxia , Huang Xiaoting , Xie Mei , Guo Qiuqi
Published: October 2022

As heritage is the precious treasure of human society, heritage also carries the genes of culture. It is of vital importance to effectively develop heritage tourism resources and explore the mechanisms that influence tourists’ cultural identity. This study has integrated the stimulus-organism-response (SOR) framework with the attitude-behavior-context (ABC) theory to construct a hypothetical model of heritage tourism aesthetics, tourist involvement, mental experience, and cultural identity so as to figure out their relationships. The questionnaires were collected to investigate the impact paths and mechanisms between heritage aesthetics, tourist involvement, mental experience, and cultural identity. The structural equation model was used to examine the relationship between heritage tourism aesthetics, tourist involvement, mental experience, and cultural identity. The main findings include: (1) the positive impact of aesthetics driving mental experience and cultural identity is significant; (2) the impact of tourist involvement on mental experience and cultural identity is also significant; (3) the impact of aesthetics on cultural identity is not significant, but mental experience mediates the relationship between aesthetics and cultural identity in heritage tourism. This study provides a new research framework and perspective for the aesthetics, tourist involvement, mental experience, and cultural identity of tourists in heritage tourism. This study also provides practical implications for government culture sectors to propagandize culture and for heritage destination managers to better manage heritage sites.
Impact of personality traits on start-up preparation of Hong Kong youths
Authors: Zhuang Jiahao , Xiong Rui , Sun Hongyi
Published: October 2022

Entrepreneurship is a tool for driving economic and social progress. Especially in Hong Kong, the government has recently taken steps to encourage young people to engage in entrepreneurship. However, Hong Kong youths’ entrepreneurial intentions are still low. The objective of this study is to empirically explore the impacts of personality traits on start-up preparation among Hong Kong youths through the constructs of the theory of planned behavior (TPB). Through a multi-channel survey, we finally collected 230 valid respondents aged 18 to 40. In addition, this study used SmartPLS software to conduct confirmatory factor analysis for the measurement model as well as path analysis for the structural model. This study’s results suggested that creativity, risk-taking propensity, need for achievement, and internal locus of control influence TPB models’ components and indirectly influence start-up preparation through TPB models’ components. Also, attitude and perceived behavioral control influence intention, and intention influences preparation. Furthermore, prior entrepreneurial experience and entrepreneurship education positively influence preparation. In conclusion, this study revealed the mediating effects of TPB components between four personality traits and start-up preparation. Finally, this study had theoretical implications by providing the influence of six personality traits on youths’ entrepreneurial intention and preparation through the TPB model and the human capital theory. This study also had practical implications by providing suggestions for the government and higher education institutions.
Face-to-face contact during infancy: How the development of gaze to faces feeds into infants’ vocabulary outcomes
Authors: Belteki Zsofia , van den Boomen Carlijn , Junge Caroline
Published: October 2022

Infants acquire their first words through interactions with social partners. In the first year of life, infants receive a high frequency of visual and auditory input from faces, making faces a potential strong social cue in facilitating word-to-world mappings. In this position paper, we review how and when infant gaze to faces is likely to support their subsequent vocabulary outcomes. We assess the relevance of infant gaze to faces selectively, in three domains: infant gaze to different features within a face (that is, eyes and mouth); then to faces (compared to objects); and finally to more socially relevant types of faces. We argue that infant gaze to faces could scaffold vocabulary construction, but its relevance may be impacted by the developmental level of the infant and the type of task with which they are presented. Gaze to faces proves relevant to vocabulary, as gazes to eyes could inform about the communicative nature of the situation or about the labeled object, while gazes to the mouth could improve word processing, all of which are key cues to highlighting word-to-world pairings. We also discover gaps in the literature regarding how infants’ gazes to faces (versus objects) or to different types of faces relate to vocabulary outcomes. An important direction for future research will be to fill these gaps to better understand the social factors that influence infant vocabulary outcomes.
Work schedule flexibility and teleworking were not good together during COVID-19 when testing their effects on work overload and mental health
Authors: Yeves Jesús , Bargsted Mariana , Torres-Ochoa Cristian
Published: October 2022

The COVID-19 pandemic has driven organizations to implement various flexible work arrangements. Due to a lack of longitudinal studies, there is currently no consensus in specialized literature regarding the consequences of flexible work arrangements on employee mental health, as well any long term potential impacts. Using the Job Demand-Resource Model, this study documents consequences of the implementation of two types of flexible work arrangement: work schedule flexibility and teleworking on employee mental health over time, and the mediating role played by work overload during the accelerated implementation of flexible work arrangements in the course of the COVID-19 pandemic. Using a longitudinal design and probabilistic sampling, 209 workers participated in this study, twice answering a flexible work arrangement and mental health questionnaire during the pandemic. Findings of this moderated-mediation suggest that work schedule flexibility generates positive effects on mental health over time due to decreased work overload, but only for employees not working from home. These results offer theoretical and practical implications applicable to organizations considering implementation of flexible work arrangements, particularly with regard to how these flexible practices could support a balance between demand and resources, their impact on work overload, and employee mental health over time.
Altruistic preferences of pre-service teachers: The mediating role of empathic concern and the moderating role of self-control
Authors: Li Maohao , Li Wei , Yang Qun , Huang Lihui
Published: October 2022

Empathy and altruistic behavior are more crucial abilities for pre-service teachers to possess when compared with other study fields. The relationship between empathy and altruistic behavior in Chinese pre-service teachers and their underlying mechanisms, however, has received relatively little attention in the literature. Therefore, the goal of the current study was to examine the links between study fields (i.e., pre-service teachers whose study field is pedagogy and non-pre-service teachers whose study field is non-pedagogy), self-control, emotional empathy (i.e., empathic concern), and altruistic preferences among undergraduates and graduates in five Chinese universities (the age range of participants is 18–20 years; 58.4% women) with the Interpersonal Reactivity Index-C Questionnaire, the Self-Control Scale, and the Chinese Self-Report Altruism Scale tests. The results showed a significant difference between pre-service and non-pre-service teachers in empathic concern and self-control. Furthermore, empathic concern and altruistic behavior tendency of pre-service teachers were significantly higher than those of non-pre-service teachers. Moreover, mediation analyses indicated that empathic concern partially mediated the relationship between study fields and altruistic tendency. Moderated mediation analysis further revealed that self-control buffered the relation between empathic concern and altruistic behavior tendency. These results demonstrate that altruistic tendency of pre-service teachers is influenced by empathic concern and self-control.
Validation and application of the Non-Verbal Behavior Analyzer: An automated tool to assess non-verbal emotional expressions in psychotherapy
Authors: Terhürne Patrick , Schwartz Brian , Baur Tobias , Schiller Dominik , Eberhardt Steffen T. , André Elisabeth , Lutz Wolfgang
Published: October 2022

Background

Emotions play a key role in psychotherapy. However, a problem with examining emotional states via self-report questionnaires is that the assessment usually takes place after the actual emotion has been experienced which might lead to biases and continuous human ratings are time and cost intensive. Using the AI-based software package Non-Verbal Behavior Analyzer (NOVA), video-based emotion recognition of arousal and valence can be applied in naturalistic psychotherapeutic settings. In this study, four emotion recognition models (ERM) each based on specific feature sets (facial: OpenFace, OpenFace-Aureg; body: OpenPose-Activation, OpenPose-Energy) were developed and compared in their ability to predict arousal and valence scores correlated to PANAS emotion scores and processes of change (interpersonal experience, coping experience, affective experience) as well as symptoms (depression and anxiety in HSCL-11).

Materials and methods

A total of 183 patient therapy videos were divided into a training sample (55 patients), a test sample (50 patients), and a holdout sample (78 patients). The best ERM was selected for further analyses. Then, ERM based arousal and valence scores were correlated with patient and therapist estimates of emotions and processes of change. Furthermore, using regression models arousal and valence were examined as predictors of symptom severity in depression and anxiety.

Results

The ERM based on OpenFace produced the best agreement to the human coder rating. Arousal and valence correlated significantly with therapists’ ratings of sadness, shame, anxiety, and relaxation, but not with the patient ratings of their own emotions. Furthermore, a significant negative correlation indicates that negative valence was associated with higher affective experience. Negative valence was found to significantly predict higher anxiety but not depression scores.

Conclusion

This study shows that emotion recognition with NOVA can be used to generate ERMs associated with patient emotions, affective experiences and symptoms. Nevertheless, limitations were obvious. It seems necessary to improve the ERMs using larger databases of sessions and the validity of ERMs needs to be further investigated in different samples and different applications. Furthermore, future research should take ERMs to identify emotional synchrony between patient and therapists into account.
The main effect and gene-environment interaction effect of the ADCYAP1R1 polymorphism rs2267735 on the course of posttraumatic stress disorder symptoms—A longitudinal analysis
Authors: Zhang Jingyi , Li Gen , Yang Haibo , Cao Chengqi , Fang Ruojiao , Liu Ping , Luo Shu , Zhao Guangyi , Zhang Yingqian , Zhang Kunlin , Wang Li
Published: October 2022

Background

Many studies have been performed to investigate the association between the ADCYAP1R1 polymorphism rs2267735 and posttraumatic stress disorder (PTSD), but the results have been inconsistent, and the way in which this gene affects the course of PTSD has not been widely investigated. Thus, a longitudinal study of the course (development trajectory) of PTSD is needed.

Methods

In this study, we performed a longitudinal analysis of rs2267735 in 1017 young, trauma-exposed Chinese people (549 females and 468 males, ranging from 7 to 11 years old). At four time points after trauma exposure (2.5, 3.5, 4.5, and 5.5 years), we measured PTSD symptoms with the University of California, Los Angeles PTSD Reaction Index (PTSD-RI) for DSM-IV (Child Version). We employed a latent growth model (LGM) for the longitudinal data to test the association between rs2267735 (main and gene-environment interaction effects) and the course of PTSD symptoms.

Results

The results of LGM showed that the gene-environment interaction (rs2267735 × trauma exposure) effects were associated with PTSD symptoms in girls at 2.5 years (β = –0.291 and P = 0.013 for LGM intercept). The gene-environment interaction (rs2267735 × trauma exposure) effect was also correlated with PTSD symptoms in girls at 3.5 and 4.5 years (β = –0.264 and P = 0.005; β = –0.217 and P = 0.013).

Conclusion

Our study revealed that the gene-environment interaction of the ADCYAP1R1 polymorphism rs2267735 is associated with PTSD symptoms in girls at 2.5 years and that the effects may be stable over time and not related to the PTSD symptom recovery rate. This is the first study to detect the how the ADCYAP1R1 gene affects the course of PTSD after trauma exposure in a longitudinal view.
Suboxone: History, controversy, and open questions
Authors: Sivils Andy , Lyell Paige , Wang John Q. , Chu Xiang-Ping
Published: October 2022

There are more than 200 opioid overdose deaths each day in the US. In combating this epidemic we look to available treatment tools. Here, we find only three medications approved by the Food and Drug Administration (FDA) for the treatment of opioid use disorder. Of the three, buprenorphine is of particular importance due to its reduced overdose potential as a partial opioid agonist. Evidence supports its clinical equivalence to its full agonist cousin methadone, and suggests that it is better slated for long-term treatment of opioid use disorder compared to the non-selective opioid antagonist naltrexone. Buprenorphine is most popularized within Suboxone, a medication which also contains the non-selective opioid antagonist naloxone. The naloxone has no additional effect when the drug is taken as instructed, as it is intended to prevent diversion in those that would attempt to inject the medication. While Suboxone is regarded by some as the future of medical treatment, others have expressed concerns. This review aims to explore the history, controversy, and open questions that surround buprenorphine and its most prescribed variation, Suboxone. These include its pharmacological, legislative, and social history, alternative indications, efficacy as a treatment of opioid use disorder, and more. Armed with this information, the reader will have a more in-depth and holistic understanding of the medication’s place in their community.
Effect of microplastics on nasal and intestinal microbiota of the high-exposure population
Authors: Zhang Xiyu , Wang Heting , Peng Sihan , Kang Jian , Xie Ziyan , Tang Ruobing , Xing Yiqian , He Yuchi , Yuan Haipo , Xie Chunguang , Liu Ya
Published: October 2022

Background

Microplastic has become a growing environmental problem. A balanced microbial environment is an important factor in human health. This study is the first observational cross-sectional study focusing on the effects of microplastics on the nasal and gut microbiota in a highly exposed population.

Methods

We recruited 20 subjects from a Plastic Factory (microplastics high-exposure area) and the other 20 from Huanhuaxi Park (microplastics low-exposure area) in Chengdu, China. We performed the microplastic analysis of soil, air, and intestinal secretions by laser infrared imaging, and microbiological analysis of nasal and intestinal secretions by 16S rDNA sequencing.

Results

The result shows that the detected points of microplastics in the environment of the high-exposure area were significantly more than in the low-exposure area. Polyurethane was the main microplastic component detected. The microplastic content of intestinal secretions in the high-exposure group was significantly higher than in the low-exposure group. Specifically, the contents of polyurethane, silicone resin, ethylene-vinyl acetate copolymer, and polyethylene in the high-exposure group were significantly higher than in the low-exposure group. Moreover, high exposure may increase the abundance of nasal microbiotas, which are positively associated with respiratory tract diseases, such as Klebsiella and Helicobacter, and reduce the abundance of those beneficial ones, such as Bacteroides. Simultaneously, it may increase the abundance of intestinal microbiotas, which are positively associated with digestive tract diseases, such as Bifidobacterium, Streptococcus, and Sphingomonas, and reduce the abundance of intestinal microbiotas, which are beneficial for health, such as Ruminococcus Torquesgroup, Dorea, Fusobacterium, and Coprococcus. A combined analysis revealed that high exposure to microplastics may not only lead to alterations in dominant intestinal and nasal microbiotas but also change the symbiotic relationship between intestinal and nasal microbiotas.

Conclusion

The results innovatively revealed how microplastics can affect the intestinal and nasal microecosystems.

Clinical trial registration

ChiCTR2100049480 on August 2, 2021.
Longitudinal effects of exercise according to the World Health Organization guidelines on cognitive function in middle-aged and older adults
Authors: Kim Dasom , Ko Young , Jung Aeri
Published: October 2022

Purpose

To investigate the longitudinal effects of adequate exercise, defined as an exercise duration of ≥150 min/week by the World Health Organization (WHO), on cognitive function in middle-aged adults.

Methods

This study was a longitudinal panel analysis using secondary data obtained from the Korean Longitudinal Study of Aging (KLoSA) database, with 4,825 participants registered and comprising five rounds of survey data in 2-year intervals from 2010 to 2018. The participants were divided into the adequate exercise (≥150 min/week), deficient exercise (<150 min/week), and no exercise groups according to the WHO definition, and their cognitive decline over the 8-year period was analyzed. Further, we investigated the longitudinal effects of exercise using a fixed effects model with cognitive function as the dependent variable.

Results

In the dementia group, both deficient (<150 min/week) and adequate (≥150 min/week) exercises had statistically significantly positive effects on cognitive function. However, the coefficient size was not significantly larger in the adequate exercise group than in the deficient exercise group. In the participants with mild cognitive impairment (MCI), an adequate exercise level had significantly positive effects on cognitive function, while a deficient exercise level did not. In the participants with normal cognition, an adequate exercise level was not significantly associated with changes in cognitive function.

Conclusion

Continuous exercise can have a positive influence on cognitive function scores in middle-aged and older adults with MCI or dementia, but the findings cannot substantiate that adequate exercise (≥150 min/week) is more effective compared to deficient exercise (<150 min/week).
Machine learning-based classification of circadian rhythm characteristics for mild cognitive impairment in the elderly
Authors: Liu Zhizhen , Zhang Lin , Wu Jingsong , Zheng Zhicheng , Gao Jiahui , Lin Yongsheng , Liu Yinghua , Xu Haihua , Zhou Yongjin
Published: October 2022

Introduction

Using wrist-wearable sensors to ecological transient assessment may provide a more valid assessment of physical activity, sedentary time, sleep and circadian rhythm than self-reported questionnaires, but has not been used widely to study the association with mild cognitive impairment and their characteristics.

Methods

31 normal cognitive ability participants and 68 MCI participants were monitored with tri-axial accelerometer and nocturnal photo volumetric pulse wave signals for 14 days. Two machine learning algorithms: gradient boosting decision tree and eXtreme gradient boosting were constructed using data on daytime physical activity, sedentary time and nighttime physiological functions, including heart rate, heart rate variability, respiratory rate and oxygen saturation, combined with subjective scale features. The accuracy, precision, recall, F1 value, and AUC of the different models are compared, and the training and model effectiveness are validated by the subject-based leave-one-out method.

Results

The low physical activity state was higher in the MCI group than in the cognitively normal group between 8:00 and 11:00 (P < 0.05), the daily rhythm trend of the high physical activity state was generally lower in the MCI group than in the cognitively normal group (P < 0.05). The peak rhythms in the sedentary state appeared at 12:00–15:00 and 20:00. The peak rhythms of rMSSD, HRV high frequency output power, and HRV low frequency output power in the 6h HRV parameters at night in the MCI group disappeared at 3:00 a.m., and the amplitude of fluctuations decreased; the amplitude of fluctuations of LHratio nocturnal rhythm increased and the phase was disturbed; the oxygen saturation was between 90 and 95% and less than 90% were increased in all time periods (P < 0.05). The F1 value of the two machine learning algorithms for MCI classification of multi-feature data combined with subjective scales were XGBoost (78.02) and GBDT (84.04).

Conclusion

By collecting PSQI Scale data combined with circadian rhythm characteristics monitored by wrist-wearable sensors, we are able to construct XGBoost and GBDT machine learning models with good discrimination, thus providing an early warning solution for identifying family and community members with high risk of MCI.
Predicting COVID-19 community infection relative risk with a Dynamic Bayesian Network
Authors: Johnson Daniel P. , Lulla Vijay
Published: October 2022

As COVID-19 continues to impact the United States and the world at large it is becoming increasingly necessary to develop methods which predict local scale spread of the disease. This is especially important as newer variants of the virus are likely to emerge and threaten community spread. We develop a Dynamic Bayesian Network (DBN) to predict community-level relative risk of COVID-19 infection at the census tract scale in the U.S. state of Indiana. The model incorporates measures of social and environmental vulnerability—including environmental determinants of COVID-19 infection—into a spatial temporal prediction of infection relative risk 1-month into the future. The DBN significantly outperforms five other modeling techniques used for comparison and which are typically applied in spatial epidemiological applications. The logic behind the DBN also makes it very well-suited for spatial-temporal prediction and for “what-if” analysis. The research results also highlight the need for further research using DBN-type approaches that incorporate methods of artificial intelligence into modeling dynamic processes, especially prominent within spatial epidemiologic applications.
Associations of combined lifestyle behaviors with all-cause and cardiovascular mortality in adults: A population-based cohort study in Jiangxi Province of China
Authors: Wang Tao , Ding Congcong , Zhou Wei , Zhu Lingjuan , Yu Chao , Huang Xiao , Bao Huihui , Cheng Xiaoshu
Published: October 2022

Background

Data are limited on the impact of combined lifestyle behaviors on mortality in Jiangxi Province, China.

Objective

The study examined the association between combined lifestyle behaviors and all-cause and cardiovascular disease (CVD) mortality in Jiangxi province.

Methods

The baseline survey was completed in Jiangxi Province from November 2013 to August 2014. We conducted a follow-up on 12,608 participants of 35 years of age or older from July 2019 to October 2020. Four known lifestyle behaviors were evaluated: alcohol consumption, smoking, diet (AHEI scores), and physical activity. Cox regression analysis was performed to determine the association of combined lifestyle behaviors with all-cause and CVD mortality.

Results

During 65,083 person-years of follow-up, among the 11,622 participants (mean age 59.1 years; 40.1% men) 794 deaths occurred, including 375 deaths from CVD disease in this study. Compared to the favorable lifestyle group, the adjusted HR of all-cause mortality was 1.25 (95% CI, 1.03–1.53) for the intermediate lifestyle group and 1.37 (95% CI, 1.11–1.71) for the unfavorable lifestyle group. Compared to the favorable lifestyle group, the adjusted HR of CVD mortality was 1.50 (95% CI, 1.11–2.03) for the intermediate lifestyle group and 1.58 (95% CI, 1.14–2.20) for the unfavorable lifestyle group. Significant interactions of lifestyle and BMI (P for interaction <0.05) with the risk of all-cause mortality and CVD mortality were observed.

Conclusion

In the current study, we reaffirm the associations of combined lifestyle factors with total and CVD mortality in Jiangxi Province, our data suggest that an unfavorable lifestyle was associated with a substantially increased risk of all-cause and CVD mortality.
Optimal information disclosure strategy in the primary healthcare service market: From the perspective of signaling theory
Authors: Liu Jianyue , Ma Zhiqiang , Su Jialu , Ge Bailin
Published: October 2022

The promotion of general practitioner (GP) contract service is one of the key components of China's healthcare reform. We consider GPs providing primary health services with private competency information over two periods, where patients decide when to sign. Two types of GPs are considered: those with higher and lower competency. Under asymmetric information, to spur the patients' incentive to sign, the GPs can move to offer competency disclosure schemes to patients, for example, separating or pooling, through which true competency information is revealed, respectively. We investigate three scenarios, which are referred to as “separating-separating,” “pooling-separating,” and “pooling-pooling.” The results of the three scenarios yield intriguing insights into the impact of the GP's competency disclosure decisions. Findings include that GPs prefer the “pooling-separating” strategy, but patients prefer “separating-separating.” Besides, an extremely low cure rate may enable GPs to conceal some competency information. Furthermore, low-competency GPs may exaggerate their competency level for profit, but greater efforts in disclosing competency information may result in diminished benefits. Therefore, to promote the services of GPs, the core is always to improve GPs' competency.
Elements for successful implementation of a clinic-based health literacy intervention
Authors: Macauda Mark M. , Arent Michelle A. , Sakhuja Mayank , Yelton Brooks , Noblet Samuel , Fedrick Delores , Zona Diana , New Cyndi , Isenhower William D. , Wandersman Abraham , Friedman Daniela B.
Published: October 2022

Improving health literacy is a national public health priority. Given the context of the COVID-19 pandemic, it is even more critical for health and medical information to be clear and understandable for patients and their families. Clinic-based programs to improve health literacy need to be pragmatic, feasible, and helpful for the implementing clinic and patients. This paper describes the development, implementation, and evaluation of a pragmatic, clinic-based health literacy intervention in a safety-net clinic that serves uninsured and indigent patients. Study methods are guided by a previous pilot study and components recommended for pragmatic interventions. An electronic readiness assessment was distributed to out-patient clinics affiliated with a statewide hospital association. The AskMe3 tool was used for the intervention as it is evidence informed and relatively easy to implement. Implementation included ongoing dialogue between the clinic and the academic research team. Within the implementing clinic, data collected from patients via verbally administered questionnaires was analyzed using descriptive statistics and chi-squares. Interview data collected from the clinic director was analyzed qualitatively for themes. The implementing clinic had some of the lowest average scores of the 34 clinics who participated in the initial readiness assessment. Despite this, they were able to successfully implement the health literacy intervention during a global pandemic. Eighty-eight participants completed patient questionnaires at this clinic. Most patients (96%) agreed the AskMe3 questions helped them talk with the doctor or nurse at their current appointment. Most (99%) also perceived the AskMe3 tool to be very helpful when used in a clinical setting. The clinic director offered that the staff initially thought the intervention would be difficult to implement. However, implementation by clinic volunteers with encouragement and prioritization of health literacy by the clinic director contributed to success. When considering interventions for clinical settings, a pragmatic approach can help with selection and implementation of a program that fits with the realities on the ground. Further, frequent technical assistance can help resolve implementation barriers. Interventions utilizing tools such as AskMe3, because of their simplicity, allow creative solutions to capacity issues for clinics who see a need for health literacy improvements.
The prevalence of probable depression and probable anxiety, and associations with adverse childhood experiences and socio-demographics: A national survey in South Africa
Authors: Craig Ashleigh , Rochat Tamsen , Naicker Sara N. , Mapanga Witness , Mtintsilana Asanda , Dlamini Siphiwe N. , Ware Lisa J. , Du Toit Justin , Draper Catherine E. , Richter Linda , Norris Shane A.
Published: October 2022

Objective and methods

Mental health problems among adults are a growing public health concern, and middle-income countries such as South Africa are disproportionally affected. Using a large scale nationally representative weighted survey, we assessed the prevalence of probable depression, probable anxiety, and adverse childhood experiences (ACEs), and explored associations between probable depression, probable anxiety, ACEs, socio-economic status, and demographic characteristics.

Results

Nationally, 25.7, 17.8, and 23.6% of respondents, respectively, reported scores of ≥10 on the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7), indicating probable depression or probable anxiety, and an ACE score of ≥4 (high exposure). Overall probable depression prevalence across South Africa varied from 14.7 to 38.8%. Both probable depression and probable anxiety were more frequently reported among adults who were: retired and older (>65 years of age), and widowed, divorced, or separated; living in metropolitan areas; and only had primary school education. In a multivariable adjusted logistic regression, the likelihood of reporting probable depression or probable anxiety was also found to increase with each standard deviation increase in the ACE score (p < 0.001), independent of other socio-demographic determinants.

Conclusion

The prevalence of probable depression among respondents in South Africa varies significantly across the nine provinces. Furthermore, higher ACE score and several socio-demographic determinants were associated with a higher likelihood of probable depression and probable anxiety. Adult mental health services are urgently needed to identify groups of the population vulnerable to mental health problems for better targeting of interventions. Given the range of probable depression prevalence across the country, provincial level plans and resources should also reflect the burden of mental health problems in that province.
IRE-1 endoribonuclease activity declines early in C. elegans adulthood and is not rescued by reduced reproduction
Authors: De-Souza Evandro A. , Cummins Nadia , Taylor Rebecca C.
Published: October 2022

The proteome of a cell helps to define its functional specialization. Most proteins must be translated and properly folded to ensure their biological function, but with aging, animals lose their ability to maintain a correctly folded proteome. This leads to the accumulation of protein aggregates, decreased stress resistance, and the onset of age-related disorders. The unfolded protein response of the endoplasmic reticulum (UPRER) is a central protein quality control mechanism, the function of which is known to decline with age. Here, we show that age-related UPRER decline in Caenorhabditis elegans occurs at the onset of the reproductive period and is caused by a failure in IRE-1 endoribonuclease activities, affecting both the splicing of xbp-1 mRNA and regulated Ire1 dependent decay (RIDD) activity. Animals with a defect in germline development, previously shown to rescue the transcriptional activity of other stress responses during aging, do not show restored UPRER activation with age. This underlines the mechanistic difference between age-associated loss of UPRER activation and that of other stress responses in this system, and uncouples reproductive status from the activity of somatic maintenance pathways. These observations may aid in the development of strategies that aim to overcome the proteostasis decline observed with aging.
The alleviating specific phobias in children trial: Challenges and solutions to implementing a randomized controlled trial in clinical services
Authors: Tindall Lucy , Scott Alexander J. , Biggs Katie , Hayward Emily , Wilson Jon , Cooper Cindy , Hargate Rebecca , Wright Barry , Gega Lina
Published: October 2022

In 2015, The Alleviating Specific Phobias Experienced by Children Trial (ASPECT) was commissioned by the National Institute for Health and Care Research (NIHR) to compare the clinical and cost-effectiveness of multi-session Cognitive Behavioral Therapy (CBT) for specific phobias in children and young people (CYP) (aged 7–16), with a briefer variant called One Session Treatment (OST). From 2016 to 2020, ASPECT recruited n = 274 CYP with specific phobias and their families from across England, including 26 Child and Adolescent Mental Health Services (CAMHS) centres, three voluntary sector centers and one University-based wellbeing service. Whilst the trial successfully reached its recruitment target, the challenges experienced in its delivery highlight the difficulties of embedding child and adolescent research into clinical settings and routine practice. Using ASPECT as a case in point, this paper explores these challenges and provides important insights and considerations of potential benefit to others conducting research within the field of child and adolescent mental health.
Mechanisms of bodily harm in emergency department youths with ADHD
Authors: Evans Spencer I. , Hale Elijah W. , Silverman Matt S.
Published: October 2022

Objectives

We sought to perform a review of emergency department data to illuminate whether there is a difference in the prevalence of severe injuries in patients with ADHD compared to patients without ADHD. We hope to illuminate whether providers should consider inquiring whether their pediatric patients have ADHD to improve long term outcomes.

Methods

This study is a retrospective cohort study of patient records contained in the TriNetX database, specifically of pediatric patients in this database who presented to an emergency department. We specifically looked at the risk difference in patients <25 years of age with ADHD, no ADHD, inattentive type ADHD, hyperactive type ADHD, and combined type ADHD who presented with any fracture, a central fracture, an upper limb fracture, a lower limb fracture, an accidental overdose, a burn injury, a drowning incident, a gunshot wounds, suffocation, and a suicide attempt.

Results

Comparison between the no-ADHD cohort and the inattentive, hyperactive/impulsive, combined, and overall ADHD cohorts revealed differences in the majority of outcomes studied. Patients with overall ADHD had significant differences in rates of all outcomes aside from the upper limb fracture. Patients with combined or hyperactive/impulsive ADHD had significant differences in all but drowning, and the inattentive cohort had significance all events.

Conclusion

The stark difference between severe injury presentations in the pediatric emergency department between children with ADHD and without ADHD suggests that providers should consider inquiring whether patients have ADHD to educate them on their risk for severe injuries.
BIN1 rs744373 SNP and APOE alleles specifically associate to common diseases
Authors: Cachide Maria , Carvalho Liliana , Rosa Ilka Martins , Wiltfang Jens , Henriques Ana Gabriela , da Cruz e Silva Odete A. B.
Published: October 2022

APOE ε4 and BIN1 are the two main genetic risk factors for sporadic Alzheimer's Disease (AD). Among several BIN1 variants, the rs744373 is frequently associated with AD risk by contributing to tau pathology and poor cognitive performance. This study addressed the association of APOE and BIN1 rs744373 to specific characteristics in a Portuguese primary care-based study group, denoted pcb-Cohort. The study included 590 participants from five primary care health centers in the Aveiro district of Portugal. Individuals were evaluated and scored for cognitive and clinical characteristics, and blood samples were collected from the volunteers meeting the inclusion and exclusion criteria (N = 505). APOE and BIN1 genotypes were determined, and their association with cognitive characteristics and other diseases that might contribute to cognitive deficits, namely depression, hypertension, type 2 diabetes, dyslipidemia, osteoarticular diseases, gastrointestinal diseases, cardiovascular and respiratory diseases, was assessed. The diseases attributed to the study group were those previously diagnosed and confirmed by specialists. The results generated through multivariate analysis show that APOE ε4 carriers significantly associated with poorer cognitive performance (OR = 2.527; p = 0.031). Additionally, there was a significant risk of dyslipidemia for APOE ε4 carriers (OR = 1.804; p = 0.036), whereas BIN1 rs744373 risk-allele carriers were at a significantly lower risk of having dyslipidemia (OR = 0.558; p = 0.006). Correlations were evident for respiratory diseases in which APOE ε4 showed a protective tendency (OR = 0.515; p = 0.088), and BIN1 had a significative protective profile (OR = 0.556; p = 0.026). Not of statistical significance, APOE ε2 showed a trend to protect against type 2 diabetes (OR = 0.342; p = 0.093), in contrast BIN1 rs744373 risk-allele carriers were more likely to exhibit the disease (OR = 1.491; p = 0.099). The data here presented clearly show, for the first time, that the two top genetic risk factors for sporadic AD impact a similar group of common diseases, namely dyslipidemia, respiratory diseases, and type 2 diabetes.