bluuebunny/crossref_metadata_2025 huggingface dataset:
Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders
Authors: Erskine Daniel , Koss David , Korolchuk Viktor I. , Outeiro Tiago F. , Attems Johannes , McKeith Ian
Published: January 2021

Accumulation of the protein α-synuclein into insoluble intracellular deposits termed Lewy bodies (LBs) is the characteristic neuropathological feature of LB diseases, such as Parkinson’s disease (PD), Parkinson’s disease dementia (PDD) and dementia with LB (DLB). α-Synuclein aggregation is thought to be a critical pathogenic event in the aetiology of LB disease, based on genetic analyses, fundamental studies using model systems, and the observation of LB pathology in post-mortem tissue. However, some monogenic disorders not traditionally characterised as synucleinopathies, such as lysosomal storage disorders, iron storage disorders and mitochondrial diseases, appear disproportionately vulnerable to the deposition of LBs, perhaps suggesting the process of LB formation may be a result of processes perturbed as a result of these conditions. The present review discusses biological pathways common to monogenic disorders associated with LB formation, identifying catabolic processes, particularly related to lipid homeostasis, autophagy and mitochondrial function, as processes that could contribute to LB formation. These findings are discussed in the context of known mediators of α-synuclein aggregation, highlighting the potential influence of impairments to these processes in the aetiology of LB formation.
The role of serum C-reactive protein in the diagnosis of periprosthetic shoulder infection
Authors: Akgün Doruk , Wiethölter Mats , Siegert Paul , Danzinger Victor , Minkus Marvin , Braun Karl Friedrich , Moroder Philipp
Published: January 2021

Introduction

There is a paucity of literature regarding serum C-reactive protein (CRP) in the evaluation of a shoulder periprosthetic joint infection (PJI). The purpose of the current study was to establish cutoff values for diagnosing shoulder PJI and evaluate the influence of the type of infecting microorganism and the classification subgroups according to last proposed International Consensus Meeting (ICM) criteria on the CRP level.

Materials and methods

A retrospective analysis of all 136 patients, who underwent septic or aseptic revision shoulder arthroplasty in our institution between January 2010 and December 2019, was performed. Shoulder PJI was defined according to the last proposed definition criteria of the ICM. Serum CRP levels were compared between infected and non-infected cases, between infection subgroups, as well as between different species of infecting microorganisms. A receiver-operating characteristic (ROC) analysis was performed to display sensitivity and specificity of serum CRP level for shoulder PJI.

Results

A total of 52 patients (38%) were classified as infected, 18 meeting the criteria for definitive infection, 26 for probable infection and 8 for possible infection. According to the ROC curve, an optimized serum CRP threshold of 7.2 mg/l had a sensitivity of 69% and specificity of 74% (area under curve = 0.72). Patients with definitive infection group demonstrated significantly higher median serum CRP levels (24.3 mg/l), when compared to probable, possible infection groups and PJI unlikely group (8 mg/l, 8.3 mg/l, 3.6 mg/l, respectively, p < 0.05). The most common isolated microorganism was Cutibacterium acnes in 25 patients (48%) followed by coagulase-negative staphylococci (CNS) in 20 patients (39%). Patients with a PJI caused by high-virulent microorganisms had a significantly higher median serum CRP level compared to patients with PJI caused by low-virulent microorganisms (48 mg/l vs. 11.3 mg/l, p = 0.04).

Conclusions

Serum CRP showed a low sensitivity and specificity for the diagnosis of shoulder PJI, even applying cutoffs optimized by receiver-operating curve analysis. Low-virulent microorganisms and patients with probable and possible infections are associated with lower CRP levels compared to patients with definitive infection and infections caused by high-virulent microorganisms.

Level of evidence

Diagnostic Level III.
Development of the mouse anterior amygdalar radial unit marked by Lhx9-expression
Authors: Garcia-Calero Elena , Puelles Luis
Published: January 2021

The amygdala in mammals plays a key role in emotional processing and learning, being subdivided in pallial and subpallial derivatives. Recently, the cortical ring model and the pallial amygdalar radial model (Puelles et al. 2019; Garcia-Calero et al. 2020) described the pallial amygdala as an histogenetic field external to the allocortical ring, and subdivided it in five major radial domains calledlateral, basal, anterior, posterior and retroendopiriformunits. Theanteriorradial unit, whose cells typically express theLhx9gene (see molecular profile in Garcia-Calero et al. 2020), is located next to the pallial/subpallial boundary. This radial domain shows massive radial translocation and accumulation of its derivatives into its intermediate and superficial strata, with only a glial palisade representing its final periventricular domain. To better understand the development of this singular radial domain, not described previously, we followed the expression ofLhx9during mouse amygdalar development in the context of the postulated radial subdivisions of the pallial amygdala and other telencephalic developmental features.
Neural pathways of olfactory kin imprinting and kin recognition in zebrafish
Authors: Gerlach Gabriele , Wullimann Mario F.
Published: January 2021

Teleost fish exhibit extraordinary cognitive skills that are comparable to those of mammals and birds. Kin recognition based on olfactory and visual imprinting requires neuronal circuits that were assumed to be necessarily dependent on the interaction of mammalian amygdala, hippocampus, and isocortex, the latter being a structure that teleost fish are lacking. We show that teleosts—beyond having a hippocampus and pallial amygdala homolog—also have subpallial amygdalar structures. In particular, we identify the medial amygdala and neural olfactory central circuits related to kin imprinting and kin recognition corresponding to an accessory olfactory system despite the absence of a separate vomeronasal organ.
Spatial information from the odour environment in mammalian olfaction
Authors: Marin Alina Cristina , Schaefer Andreas T , Ackels Tobias
Published: January 2021

The sense of smell is an essential modality for many species, in particular nocturnal and crepuscular mammals, to gather information about their environment. Olfactory cues provide information over a large range of distances, allowing behaviours ranging from simple detection and recognition of objects, to tracking trails and navigating using odour plumes from afar. In this review, we discuss the features of the natural olfactory environment and provide a brief overview of how odour information can be sampled and might be represented and processed by the mammalian olfactory system. Finally, we discuss recent behavioural approaches that address how mammals extract spatial information from the environment in three different contexts: odour trail tracking, odour plume tracking and, more general, olfactory-guided navigation. Recent technological developments have seen the spatiotemporal aspect of mammalian olfaction gain significant attention, and we discuss both the promising aspects of rapidly developing paradigms and stimulus control technologies as well as their limitations. We conclude that, while still in its beginnings, research on the odour environment offers an entry point into understanding the mechanisms how mammals extract information about space.
Correction to: Population cycles and outbreaks of small rodents: ten essential questions we still need to solve
Authors: Andreassen Harry P. , Sundell Janne , Ecke Fraucke , Halle Stefan , Haapakoski Marko , Henttonen Heikki , Huitu Otso , Jacob Jens , Johnsen Kaja , Koskela Esa , Luque-Larena Juan Jose , Lecomte Nicolas , Leirs Herwig , Mariën Joachim , Neby Magne , Rätti Osmo , Sievert Thorbjörn , Singleton Grant R. , van Cann Joannes , Vanden Broecke Bram , Ylönen Hannu
Published: January 2021

Authors would like to correct error in affiliation in the original publication of the article.
Using Classical Test Theory to Determine the Psychometric Properties of the Deglutition Handicap Index
Authors: Speyer Renée , Cordier Reinie , Bouix Clara , Gallois Yohan , Woisard Virginie
Published: January 2021

The Deglutition Handicap Index (DHI) is a self-report measure for patients at risk of oropharyngeal dysphagia on deglutition-related aspects of functional health status (FHS) and health-related quality of life (HR-QoL). The DHI consists of 30 items which are subsumed within the Symptom, Functional and Emotional subscales. The purpose of this study was to evaluate the psychometric properties of the DHI using Classic Test Theory according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) criteria. A total of 453 patients with dysphagia with different aetiologies were recruited concurrently at two academic hospitals. Dysphagia was confirmed by fiberoptic endoscopic and/or videofluoroscopic evaluation of swallowing. In addition, a healthy control group of 132 participants were recruited. Structural validity was determined using exploratory and confirmatory factor analyses and internal consistency by calculating Cronbach’s alpha coefficients. Hypothesis testing was evaluated using Mann–WhitneyU-tests, linear regression analysis and correlations analysis. Diagnostic performance and receiver operating characteristic curves analysis were calculated. Factor analyses indicated that the DHI is a unidimensional measure. The DHI has good internal consistency with some indication of item redundancy, weak to moderate structural validity and strong hypothesis testing for construct validity. The DHI shows high diagnostic performance as part of criterion validity. These findings support that the DHI is an appropriate choice as a patient self-report measure to evaluate FHS and HR-QoL in dysphagia. Ongoing validation to assess the measure for possible item redundancy and to examine the dimensionality of the DHI using item response theory is recommended.
Respond of the different human cranial bones to pin-type head fixation device
Authors: Visentin Alissa , van Dooren Kristina , Mertens Jan , Brina Olivier , Schaller Karl
Published: January 2021

Background

At this juncture, there is no consensus in the literature for the use and the safety of pin-type head holders in cranial procedures.

Methods

The present analysis of the bone response to the fixation of the instrument provides data to understand its impact on the entire skull as well as associated complications. An experimental study was conducted on fresh-frozen human specimens to analyze the puncture hole due to the fixation of each single pin of the pin-type head holder. Cone-beam CT images were acquired to measure the diameter of the puncture hole caused by the instrument according to several parameters: the pin angle, the clamping force, and different neurosurgical approaches most clinically used.

Results

The deepest hole, 2.67 ± 0.27 mm, was recorded for a 35° angle and a clamping force of 270 N at the middle fossa approach. The shallowest hole was 0.62 ± 0.22 mm for the 43° angle with a pinning force of 180 N in the pterional approach. The pterional approach had a significantly different effect on the depth of the puncture hole compared with the middle fossa craniotomy for 270 N pinning at 35° angle. The puncture hole measured with the 43° angle and 180 N force in prone position is significantly different from the other approaches with the same force.

Conclusions

These results could lead to recommendations about the use of the head holder depending on the patient’s history and cranial thickness to reduce complications associated with the pin-type head holder during clinical applications.
Botulinum toxin dosing in arm muscles: contextual factors
Authors: Dressler Dirk , Kopp Bruno , Adib Saberi Fereshte
Published: January 2021

Botulinum toxin (BT) has been successfully used for many years to treat various muscle hyperactivity disorders including dystonia and spasticity. Its dosing is guided by dosing tables describing target muscles and dose ranges. To refine the BT dosing, we wanted to analyse how contextual factors may influence the injector's final dosing decision.

In a retrospective review of real-life data of 1170 BT treatments, we studied the influence of various contextual factors on the BT doses in 21 arm muscles of 252 patients receiving BT therapy for different muscle hyperactivity disorders.

We found that BT arm doses are significantly higher in treatment of spasticity than in treatment of dystonia. We also found that spontaneous arm dystonia requires higher BT doses in a proximal application pattern, whereas task specific writer's cramp requires considerably reduced BT doses with a distal application pattern. Injections of non-arm muscles influence the BT dosing in arm muscles only marginally.

Our study demonstrates that BT dosing does not only depend on the particularities of the individual target muscle injected, such as its volume and its static or phasic function. BT dosing and its application pattern rather depend on additional contextual factors such as the aetiology and pathophysiology of the muscle hyperactivity treated. These contextual factors need to be included in dosing tables and may improve the outcome of BT therapy.
Different effects of reward value and saliency during bumblebee visual search for multiple rewarding targets
Authors: Nityananda Vivek , Chittka Lars
Published: January 2021

Several animals, including bees, use visual search to distinguish targets of interest and ignore distractors. While bee flower choice is well studied, we know relatively little about how they choose between multiple rewarding flowers in complex floral environments. Two factors that could influence bee visual search for multiple flowers are the saliency (colour contrast against the background) and the reward value of flowers. We here investigated how these two different factors contribute to bee visual search. We trained bees to independently recognize two rewarding flower types that, in different experiments, differed in either saliency, reward value or both. We then measured their choices and attention to these flowers in the presence of distractors in a test without reinforcement. We found that bees preferred more salient or higher rewarding flowers and ignored distractors. When the high-reward flowers were less salient than the low-reward flowers, bees were nonetheless equally likely to choose high-reward flowers, for the reward and saliency values we used. Bees were also more likely to attend to these high-reward flowers, spending higher inspection times around them and exhibiting faster search times when choosing them. When flowers differed in reward, we also found an effect of the training order with low-reward targets being more likely to be chosen if they had been encountered during the more immediate training session prior to the test. Our results parallel recent findings from humans demonstrating that reward value can attract attention even when targets are less salient and irrelevant to the current task.
Near future climate change projections with implications for the agricultural sector of three major Mediterranean islands
Authors: Varotsos Konstantinos V. , Karali Anna , Lemesios Giannis , Kitsara Gianna , Moriondo Marco , Dibari Camilla , Leolini Luisa , Giannakopoulos Christos
Published: January 2021

The paper presents the analysis of a sub-set of high-resolution bias-adjusted simulations from the EURO-CORDEX initiative, in order to examine the changes in the mean climate and the extremes in three Mediterranean islands, namely, Sicily, Crete and Cyprus, in the near future (2031–2060) compared to the present climate (1971–2000), under two future scenarios, i.e. RCP4.5 and RCP8.5. The analysis entails commonly used climatic indices of interest related to the islands’ agricultural sector. The results indicate robust increases for both the mean maximum and minimum temperatures on a seasonal basis, as well as for the temperature related extremes under both climate scenarios. On the contrary, the changes in precipitation are less pronounced as the changes in the seasonal precipitation are not found statistically significant for the three islands under both scenarios. The projected warming combined with the projected unchanged precipitation pattern in the future, especially in spring and summer, might expose the crops to conditions with a negative impact on the plants’ phenology, leading to implications on crop production and quality. The results presented here might be the basis for the development of an adaptation strategy specifically targeted on the three islands but also replicable to other Mediterranean islands.
Stress fibers of the aortic smooth muscle cells in tissues do not align with the principal strain direction during intraluminal pressurization
Authors: Sugita Shukei , Mizuno Naoto , Ujihara Yoshihiro , Nakamura Masanori
Published: January 2021

Stress fibers (SFs) in cells transmit external forces to cell nuclei, altering the DNA structure, gene expression, and cell activity. To determine whether SFs are involved in mechanosignal transduction upon intraluminal pressure, this study investigated the SF direction in smooth muscle cells (SMCs) in aortic tissue and strain in the SF direction. Aortic tissues were fixed under physiological pressure of 120 mmHg. First, we observed fluorescently labeled SFs using two-photon microscopy. It was revealed that SFs in the same smooth muscle layers were aligned in almost the same direction, and the absolute value of the alignment angle from the circumferential direction was 16.8° ± 5.2° (n = 96, mean ± SD). Second, we quantified the strain field in the aortic tissue in reference to photo-bleached markers. It was found in the radial-circumferential plane that the largest strain direction was − 21.3° ± 11.1°, and the zero normal strain direction was 28.1° ± 10.2°. Thus, the SFs in aortic SMCs were not in line with neither the largest strain direction nor the zero strain direction, although their orientation was relatively close to the zero strain direction. These results suggest that SFs in aortic SMCs undergo stretch, but not maximal and transmit the force to nuclei under intraluminal pressure.
Population size estimation based upon zero-truncated, one-inflated and sparse count data
Authors: Böhning Dankmar , Friedl Herwig
Published: January 2021

Estimating the size of a hard-to-count population is a challenging matter. In particular, when only few observations of the population to be estimated are available. The matter gets even more complex when one-inflation occurs. This situation is illustrated with the help of two examples: the size of a dice snake population in Graz (Austria) and the number of flare stars in the Pleiades. The paper discusses how one-inflation can be easily handled in likelihood approaches and also discusses how variances and confidence intervals can be obtained by means of a semi-parametric bootstrap. A Bayesian approach is mentioned as well and all approaches result in similar estimates of the hidden size of the population. Finally, a simulation study is provided which shows that the unconditional likelihood approach as well as the Bayesian approach using Jeffreys’ prior perform favorable.
Quality control of long-term mass-reared Aedes albopictus for population suppression
Authors: Li Yongjun , Zhang Meichun , Wang Xiaohua , Zheng Xiaoying , Hu Zhiyong , Xi Zhiyong
Published: January 2021

The endosymbiotic bacterium Wolbachia is being developed as a tool to suppress mosquito populations and their transmitted pathogens, with successful field trials in multiple countries having resulted in efforts to scale up the capacity to mass-produce mosquitoes for release. However, major challenges exist to achieving this goal, including concerns that mass-reared mosquitoes will adapt to laboratory conditions during long-term maintenance and experience inbreeding depression, resulting in poor performance of the released mosquitoes in the field. Here, we assessed the performance of the Aedes albopictus HC line infected with a triple-strain Wolbachia after mass-rearing at scaled-up densities of up to 15 million mosquitoes per week for over 50 generations. In comparison with the wild-type GUA line, the HC mosquitoes had desirable characteristics for mass-rearing and release, including robust male mating competitiveness, high female reproductive capacity, reduced vector competence for dengue virus, and increased Wolbachia density. Although the larval survival rate of the HC and GUA lines was similar, the HC larvae developed significantly faster, possibly because of up-regulation of the molting hormone 20-hydroxyecdysone-related gene E75 in the HC larvae. Our results indicate that over many generations mass-reared mosquito lines can retain their quality if large effective population sizes with sufficient genetic heterogeneity are maintained under optimized rearing conditions and demonstrate the long-term feasibility of deploying Wolbachia-based approaches for area-wide management of mosquito vectors for disease control.
The strong simple connectedness of tame algebras with separating almost cyclic coherent Auslander–Reiten components
Authors: Malicki Piotr
Published: January 2021

We study the strong simple connectedness of finite-dimensional tame algebras over an algebraically closed field, for which the Auslander–Reiten quiver admits a separating family of almost cyclic coherent components. As the main application we describe all analytically rigid algebras in this class.
Patterns and predictors of soil organic carbon storage across a continental-scale network
Authors: Nave L. E. , Bowman M. , Gallo A. , Hatten J. A. , Heckman K. A. , Matosziuk L. , Possinger A. R. , SanClements M. , Sanderman J. , Strahm B. D. , Weiglein T. L. , Swanston C. W.
Published: January 2021

The rarity of rapid campaigns to characterize soils across scales limits opportunities to investigate variation in soil carbon stocks (SOC) storage simultaneously at large and small scales, with and without site-level replication. We used data from two complementary campaigns at 40 sites in the United States across the National Ecological Observatory Network (NEON), in which one campaign sampled profiles from closely co-located intensive plots and physically composited similar horizons, and the other sampled dozens of pedons across the landscape at each site. We demonstrate some consistencies between these distinct designs, while also revealing that within-site replication reveals patterns and predictors of SOC stocks not detectable with non-replicated designs. Both designs demonstrate that SOC stocks of whole soil profiles vary across continental-scale climate gradients. However, broad climate patterns may mask the importance of localized variation in soil physicochemical properties, as captured by within-site sampling, especially for SOC stocks of discrete genetic horizons. Within-site replication also reveals examples in which expectations based on readily explained continental-scale patterns do not hold. For example, even wide-ranging drainage class sequences within landscapes do not duplicate the clear differences in profile SOC stocks across drainage classes at the continental scale, and physicochemical factors associated with increasing B horizon SOC stocks at continental scales frequently do not follow the same patterns within landscapes. Because inferences from SOC studies are a product of their context (where, when, how), this study provides context—in terms of SOC stocks and the factors that influence them—for others assessing soils and the C cycle at NEON sites.
The increasing importance of histologic grading in tailoring adjuvant systemic therapy in 30,843 breast cancer patients
Authors: van Dooijeweert C. , Baas I. O. , Deckers I. A. G. , Siesling S. , van Diest P. J. , van der Wall E.
Published: January 2021

Purpose

The large variation in histologic grading of invasive breast cancer (IBC) that has been reported likely influences tailoring adjuvant therapy. The role of grading in therapeutic decision-making in daily practice, was evaluated using the Dutch national guidelines for IBC-management.

Methods

Synoptic reports of IBC resection-specimens, obtained between 2013 and 2016, were extracted from the nationwide Dutch Pathology Registry, and linked to treatment-data from the Netherlands Cancer Registry. The relevance of grading for adjuvant chemotherapy (aCT) was quantified by identifying patients for whom grade was the determinative factor. In addition, the relation between grade and aCT-administration was evaluated by multivariate logistic regression for patients with a guideline-aCT-indication.

Results

30,843 patients were included. Applying the guideline that was valid between 2013 and 2016, grade was the determinative factor for the aCT-indication in 7744 (25.1%) patients, a percentage that even increased according to the current guideline where grade would be decisive for aCT in 10,869 (35.2%) patients. Also in current practice, the indication for adjuvant endocrine therapy (aET) would be based on grade in 9173 (29.7%) patients. Finally, as patients with lower-grade tumors receive aCT significantly less often, grade was also decisive in tailoring aCT de-escalation.

Conclusions

In the largest study published so far we illustrate the increasing importance of histologic grade in tailoring adjuvant systemic breast cancer therapy. Next to playing a key-role in aCT-indication and de-escalation, the role of grading has expanded to the indication for aET. Optimizing histologic grading by pathologists is urgently needed to diminish the risk of worse patient outcome due to non-optimal treatment.
Children and the Child Welfare System: Problems, Interventions, and Lessons from Around the World
Authors: Przeperski Jarosław , Owusu Samuel A.
Published: January 2021

Securing the welfare of children and the family is an integral part of social work. Modern society has experienced enormous changes that present both opportunities and challenges to the practice of social work to protect the welfare of children. It is thus essential that we understand the experiences of social work practitioners in different parts of the world in order to adapt practice to the changing times. To help achieve this, we present a collection of papers from around the world that presents findings on various aspects of social work research and practice involving children and the potential for improved service delivery.
Patterns and tempo of PCSK9 pseudogenizations suggest an ancient divergence in mammalian cholesterol homeostasis mechanisms
Authors: van Asch Barbara , Teixeira da Costa Luís Filipe
Published: January 2021

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a central role in cholesterol homeostasis in humans as a major regulator of LDLR levels. PCSK9 is an intriguing protease in that it does not act by proteolysis but by preventing LDLR recirculation from endosomes to the plasma membrane. This, and the inexistence of any other proteolytic substrate but itself could suggest that PCSK9 is an exquisite example of evolutionary fine-tuning. However, the gene has been lost in several mammalian species, and null alleles are present (albeit at low frequencies) in some human populations without apparently deleterious health effects, raising the possibility that the PCSK9 may have become dispensable in the mammalian lineage. To address this issue, we systematically recovered, assembled, corrected, annotated and analysed publicly available PCSK9 sequences for 420 eutherian species to determine the distribution, frequencies, mechanisms and timing of PCSK9 pseudogenization events, as well as the evolutionary pressures underlying the preservation or loss of the gene. We found a dramatic difference in the patterns of PCSK9 retention and loss between Euarchontoglires—where there is strong pressure for gene preservation—and Laurasiatheria, where multiple independent events have led to PCSK9 loss in most species. These results suggest that there is a fundamental difference in the regulation of cholesterol metabolism between Euarchontoglires and Laurasiatheria, which in turn has important implications for the use of Laurasiatheria species (e.g. pigs) as animal models of human cholesterol-related diseases.
Weighted proximity search
Authors: Rodrigues Filipe , Agra Agostinho , Hvattum Lars Magnus , Requejo Cristina
Published: January 2021

Proximity search is an iterative method to solve complex mathematical programming problems. At each iteration, the objective function of the problem at hand is replaced by the Hamming distance function to a given solution, and a cutoff constraint is added to impose that any new obtained solution improves the objective function value. A mixed integer programming solver is used to find a feasible solution to this modified problem, yielding an improved solution to the original problem. This paper introduces the concept of weighted Hamming distance that allows to design a new method called weighted proximity search. In this new distance function, low weights are associated with the variables whose value in the current solution is promising to change in order to find an improved solution, while high weights are assigned to variables that are expected to remain unchanged. The weights help to distinguish between alternative solutions in the neighborhood of the current solution, and provide guidance to the solver when trying to locate an improved solution. Several strategies to determine weights are presented, including both static and dynamic strategies. The proposed weighted proximity search is compared with the classic proximity search on instances from three optimization problems: the p-median problem, the set covering problem, and the stochastic lot-sizing problem. The obtained results show that a suitable choice of weights allows the weighted proximity search to obtain better solutions, for 75$$\%$$
%
of the cases, than the ones obtained by using proximity search and for 96$$\%$$
%
of the cases the solutions are better than the ones obtained by running a commercial solver with a time limit.
International students’ linguistic transitions into disciplinary studies: a rhizomatic perspective
Authors: Dippold Doris , Heron Marion , Gravett Karen
Published: January 2021

This paper offers a reconceptualisation of international students’ transitions into and through UK higher education. We present two case studies of students which explore their transitions in terms of their academic speaking skills from pre-sessional courses into their disciplinary studies. Students describe how the development of their confidence and performance in academic speaking was contingent on a number of factors and micro-moments, and how this progress into and within disciplinary studies often involved regression and discomfort. Nevertheless, they also talked of developing strategies to overcome challenges and the resultant learning. We argue that transitions to disciplinary studies in terms of academic speaking can be more helpfully understood as non-linear, fluid and rhizomatic. This study offers valuable insights for individuals and institutions to move away from a fixed student lifecycle perspective to consider instead how reciprocal, embedded and on-going support for international students may better reflect students’ experiences.
iDocChip: A Configurable Hardware Architecture for Historical Document Image Processing
Authors: Tekleyohannes Menbere Kina , Rybalkin Vladimir , Ghaffar Muhammad Mohsin , Varela Javier Alejandro , Wehn Norbert , Dengel Andreas
Published: January 2021

In recent years,$$\hbox {optical character recognition (OCR)}$$optical character recognition (OCR)systems have been used to digitally preserve historical archives. To transcribe historical archives into a machine-readable form, first, the documents are scanned, then an$$\hbox {OCR}$$OCRis applied. In order to digitize documents without the need to remove them from where they are archived, it is valuable to have a portable device that combines scanning and$$\hbox {OCR}$$OCRcapabilities. Nowadays, there exist many commercial and open-source document digitization techniques, which are optimized for contemporary documents. However, they fail to give sufficient text recognition accuracy for transcribing historical documents due to the severe quality degradation of such documents. On the contrary, the anyOCR system, which is designed to mainly digitize historical documents, provides high accuracy. However, this comes at a cost of high computational complexity resulting in long runtime and high power consumption. To tackle these challenges, we propose a low power energy-efficient accelerator with real-time capabilities called iDocChip, which is a configurable hybrid hardware-software programmable$$\hbox {System-on-Chip (SoC)}$$System-on-Chip (SoC)based on anyOCR for digitizing historical documents. In this paper, we focus on one of the most crucial processing steps in the anyOCR system:Text and Image Segmentation, which makes use of a multi-resolution morphology-based algorithm. Moreover, an optimized$$\hbox {FPGA}$$FPGA-based hybrid architecture of this anyOCR step along with its optimized software implementations are presented. We demonstrate our results on multiple embedded and general-purpose platforms with respect to runtime and power consumption. The resulting hardware accelerator outperforms the existing anyOCR by6.2$$\times$$×, while achieving207$$\times$$×higher energy-efficiency and maintaining its high accuracy.
Long-Term Physical Health Outcomes of Resettled Refugee Populations in the United States: A Scoping Review
Authors: Kumar Gayathri S. , Beeler Jenna A. , Seagle Emma E. , Jentes Emily S.
Published: January 2021

Several studies describe the health of recently resettled refugee populations in the US beyond the first 8 months after arrival. This review summarizes the results of these studies. Scientific articles from five databases published from January 2008 to March 2019 were reviewed. Articles were included if study subjects included any of the top five US resettlement populations during 2008–2018 and if data described long-term physical health outcomes beyond the first 8 months after arrival in the US. Thirty-three studies met the inclusion criteria (1.5%). Refugee adults had higher odds of having a chronic disease compared with non-refugee immigrant adults, and an increased risk for diabetes compared with US-born controls. The most commonly reported chronic diseases among Iraqi, Somali, and Bhutanese refugee adults included diabetes and hypertension. Clinicians should consider screening and evaluating for chronic conditions in the early resettlement period. Further evaluations can build a more comprehensive, long-term health profile of resettled refugees to inform public health practice.
Uncovering the Source of Patrimonial Voting: Evidence from Swedish Twin Pairs
Authors: Ahlskog Rafael , Brännlund Anton
Published: January 2021

The boom in wealth inequality seen in recent decades has generated a steep rise in scholarly interest in both the drivers and the consequences of the wealth gap. In political science, a pertinent question regards the political behavior across the wealth spectrum. A common argument is that the wealthy practice patrimonial voting, i.e. voting for right-wing parties to maximize returns on their assets. While this pattern is descriptively well documented, it is less certain to what extent this reflects an actual causal relationship between wealth and political preferences. In this study, we provide new evidence by exploiting wealth variation within identical twin pairs. Our findings suggest that while more wealth is descriptively connected to more support for right-wing parties, the causal impact of wealth on policy preferences is likely highly overstated. For several relevant policy areas these effects may not exist at all. Furthermore, the bias in naive observational estimates seems to be mainly driven by environmental familial confounders shared within twin pairs, rather than genetic confounding.
Interaction effects between dynamic hybrid products and traditional deferred annuities in the German life insurance market
Authors: Moretti Nikolaj , Bartels Johannes
Published: February 2021

Dynamic hybrid products emerged in 2007 and are now well established in the German life insurance market. In this article, we study interaction effects between dynamic hybrid products and traditional deferred annuity contracts, that are sold by the same insurance company. The key question we investigate is whether the presence of dynamic hybrid products has a negative effect on the payout of traditional insurance products. We do so by using data drawn from a Monte Carlo simulation that is based on a model presented in this article. These data reveal that dynamic hybrid products reduce the payment to policyholders of traditional deferred annuities via the channel of surplus participation.
Promoting Service Leadership Qualities and Well-Being among University Students: Evaluation Findings in Hong Kong
Authors: Zhu Xiaoqin , Shek Daniel T. L.
Published: February 2021

Service leadership education initiatives have been launched in Hong Kong to meet the emerging demand for service leaders and enhance university students’ well-being through nurturing not only competence but also good character and caring disposition. However, rigorous evaluation work based on validated assessment tools has not been adequately carried out to examine whether student well-being and service leadership qualities would increase after the learning process. Using a one-group pretest-posttest design, this study investigated the effectiveness of a credit-bearing subject entitled “Service Leadership” implemented in one university in Hong Kong. Based on the responses of 114 participants (49.1% boys, Age = 20.21 ± 2.96 years), it was found that students showed improvement in service leadership knowledge, attitude, and behavior after taking the subject. In addition, their life satisfaction and positive youth development attributes as indicators of well-being also significantly increased. Furthermore, the increase in well-being among students was closely associated with their attitudinal and behavioral changes but not knowledge acquisition. The present findings imply that a formal curriculum-based leadership course can be a promising way to promote student service leadership qualities and well-being.
Combating overreporting of deductions in tax returns: prefilling and restricting the deductibility of expenditures
Authors: Fochmann Martin , Hechtner Frank , Kölle Tobias , Overesch Michael
Published: January 2021

We experimentally analyze three anti-tax-evasion mechanisms: (1) prefilling of deductions in tax returns, (2) restricting tax evasion opportunities by either disallowing or (3) limiting the deductibility of expenditures. We find that prefilling compared to blank forms reduces tax evasion. Cutting the number of tax evasion opportunities by disallowing the deductibility of expenditure items is an ineffective mechanism to combat tax evasion as individuals shift their tax evasion activities from the disallowed item to other non-restricted items. In contrast, our results suggest that just limiting the deductibility of expenditures avoids this evasion-shift-effect.
Magnetic resonance imaging findings in 11 cases of dedifferentiated endometrial carcinoma of the uterus
Authors: Kikkawa Nao , Ito Kimiteru , Yoshida Hiroshi , Kato Mayumi Kobayashi , Kubo Yuko , Onishi Yasuyuki , Sugawara Haruto , Kato Tomoyasu , Kusumoto Masahiko
Published: January 2021

Purpose

We evaluated magnetic resonance imaging (MRI) findings of dedifferentiated endometrial carcinoma (DEC), comprising undifferentiated carcinoma and low-grade endometrioid carcinoma.

Materials and methods

We recruited 11 patients with pathologically proven DEC treated at our institute. We evaluated primary lesion size, location and signal intensity on MRI, and prognosis. MRI and pathological findings were compared in eight resected patients.

Results

Primary tumors ranged from 16 to 206 mm in diameter. DEC was located at the endometrium in 9 of the 11 patients; the remaining two patients showed diffuse involvement of the enlarged myometrium. These two patients with diffuse involvement type died within 4 months. Of the eight patients who underwent resection, seven had macroscopic intratumoral hemorrhage and six showed a high signal on T1-weighted images or low signal on T2-weighted images. Of the eight resected patients, four had tumor necrosis > 25% and tumor size > 5 cm. In these patients, necrosis appeared as nonenhanced areas on contrast-enhanced MRI.

Conclusion

MRI findings of DEC showed two patterns: mass-forming type and diffuse myometrial type with poor prognosis. Most patients with DEC had intratumoral hemorrhage, and large tumors (> 5 cm) had gross necrosis, which appeared as nonenhanced areas on contrast-enhanced MRI.
Comparison of cardiovascular disease and cancer prevalence between Mediterranean and north European middle-aged populations (The Cilento on Ageing Outcomes Study and The Malmö Offspring Study)
Authors: Melander Olle , Antonini Paola , Ottosson Filip , Brunkwall Louise , Gallo Widet , Nilsson Peter M. , Orho-Melander Marju , Pacente Gaetano , D’Arena Giovanni , Di Somma Salvatore
Published: January 2021

Mediterranean diet protects from both cardiovascular disease (CVD) and cancer. In the 1960s, Ancel Keys defined the concept of Mediterranean diet in the South Italian region of Cilento and proposed it as a key factor for healthy ageing in the region. The aim of the current study was to compare the prevalence of CVD and cancer between a middle-aged population from Cilento and those of a Northern European population from Malmö, Sweden. We clinically characterized two middle-aged (50–67 years of age) population-based samples from Cilento (n = 809) and Malmö (n = 1025), Sweden, respectively. Logistic regression was used to calculate odds ratios (95% confidence interval) for disease prevalence in Malmö versus Cilento inhabitants adjusted for age and sex (model 1) and adjusted for all cardiometabolic risk factors (model 2). The prevalence of hypertension, current smoking, diabetes mellitus and levels of body mass index and triglycerides were lower, whereas HDL-cholesterol was higher in Malmö than in Cilento. LDL-cholesterol was higher and estimated glomerular filtration rate was lower in Malmö than in Cilento. The odds ratio for cardiovascular disease in Malmö versus Cilento inhabitants was 1.13 (0.69–1.87) (P = 0.62) in model 1, whereas it was significantly elevated in model 2 [2.03 (1.14–3.60) (P = 0.016)]. Moreover, the odds ratio for cancer in Malmö versus Cilento was 2.78 (1.81–4.27) (P < 0.001) in model 1 and 3.11 (1.97–4.92) (P < 0.001) in model 2. The higher odds of CVD and cancer in Malmö versus Cilento, when risk factors were accounted for, suggests the existence of unknown protective factors in Cilento.
Unitary Boundary Pairs for Isometric Operators in Pontryagin Spaces and Generalized Coresolvents
Authors: Baidiuk D. , Derkach V. , Hassi S.
Published: February 2021

An isometric operatorVin a Pontryagin space$${{{\mathfrak {H}}}}$$His called standard, if its domain and the range are nondegenerate subspaces in$${{{\mathfrak {H}}}}$$H. A description of coresolvents for standard isometric operators is known and basic underlying concepts that appear in the literature are unitary colligations and characteristic functions. In the present paper generalized coresolvents of non-standard Pontryagin space isometric operators are described. The methods used in this paper rely on a new general notion of boundary pairs introduced for isometric operators in a Pontryagin space setting. Even in the Hilbert space case this notion generalizes the earlier concept of boundary triples for isometric operators and offers an alternative approach to study operator valued Schur functions without any additional invertibility requirements appearing in the ordinary boundary triple approach.
Create your own problem! When given descriptions of real-world situations, do students pose and solve modelling problems?
Authors: Hartmann Luisa-Marie , Krawitz Janina , Schukajlow Stanislaw
Published: February 2021

As problem posing has been shown to foster students’ problem-solving abilities, problem posing might serve as an innovative teaching approach for improving students’ modelling performance. However, there is little research on problem posing regarding real-world situations. The present paper addresses this research gap by using a modelling perspective to examine (1) what types of problems students pose (e.g., modelling vs. word problems) and (2) how students solve different types of self-generated problems. To answer these questions, we recruited 82 ninth- and tenth-graders from German high schools and middle schools to participate in this study. We presented students with different real-world situations. Then we asked them to pose problems that referred to these situations and to solve the problems they posed. We analyzed students’ self-generated problems and their solutions using criteria from research on modelling. Our analysis revealed that students posed problems that were related to reality and required the application of mathematical methods. Therefore, problem posing with respect to given real-world situations can be a beneficial approach for fostering modelling abilities. However, students showed a strong tendency to generate word problems for which important modelling activities (e.g., making assumptions) are not needed. Of the students who generated modelling problems, a few either neglected to make assumptions or made assumptions but were not able to integrate them adequately into their mathematical models, and therefore failed to solve those problems. We conclude that students should be taught to pose problems, in order to benefit more from this powerful teaching approach in the area of modelling.
Assessing the health-related management of people with differences of sex development
Authors: Jürgensen Martina , Rapp Marion , Döhnert Ulla , Frielitz Fabian-Simon , Ahmed Faisal , Cools Martine , Thyen Ute , Hiort Olaf
Published: January 2021

Purpose

Health care requirements and perception of people with differences of sex development (DSD) have changed enormously since the “Chicago Consensus Conference” in 2005. Therefore, new standards of care and evaluation of care have to be developed.

Methods

We summarize the social and legal approach to care for DSD during the last two decades and report the main results of European research activities.

Results

The last two decades were accompanied by legal and societal discussion regarding how to deal with a nonbinary concept of sex. This leads to the necessity to assess health care requirements for individuals with DSD in an objective manner. We briefly review the results of the recently funded European research projects dealing with health-related issues in DSD like EU COST Action DSD, I-DSD, and dsd-LIFE, and address the compilation of quality indicators that will be needed to benchmark health care provision and health care-related outcomes.

Conclusions

The benchmarking process has to be implemented among health care providers for individuals with DSD within the European Reference Networks for Rare Conditions.