bluuebunny/crossref_metadata_2025 huggingface dataset:
Newly diagnosed diabetes and outcomes after acute myocardial infarction in young adults
Authors: Ding Qinglan , Spatz Erica S , Lipska Kasia J , Lin Haiqun , Spertus John A , Dreyer Rachel P , Whittemore Robin , Funk Marjorie , Bueno Hector , Krumholz Harlan M
Published: October 2020

Objective

To examine prevalence and characteristics of newly diagnosed diabetes (NDD) in younger adults hospitalised with acute myocardial infarction (AMI) and investigate whether NDD is associated with health status and clinical outcomes over 12-month post-AMI.

Methods

In individuals (18–55 years) admitted with AMI, without established diabetes, we defined NDD as (1) baseline or 1-month HbA1c≥6.5%; (2) discharge diabetes diagnosis or (3) diabetes medication initiation within 1 month. We compared baseline characteristics of NDD, established diabetes and no diabetes, and their associations with baseline, 1-month and 12-month health status (angina-specific and non-disease specific), mortality and in-hospital complications.

Results

Among 3501 patients in Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients study, 14.5% met NDD criteria. Among 508 patients with NDD, 35 (6.9%) received discharge diagnosis, 91 (17.9%) received discharge diabetes education and 14 (2.8%) initiated pharmacological treatment within 1 month. NDD was more common in non-White (OR 1.58, 95% CI 1.23 to 2.03), obese (OR 1.72, 95% CI 1.39 to 2.12), financially stressed patients (OR 1.27, 95% CI 1.02 to 1.58). Compared with established diabetes, NDD was independently associated with better disease-specific health status and quality of life (p≤0.04). No significant differences were found in unadjusted in-hospital mortality and complications between NDD and established or no diabetes.

Conclusions

NDD was common among adults≤55 years admitted with AMI and was more frequent in non-White, obese, financially stressed individuals. Under 20% of patients with NDD received discharge diagnosis or initiated discharge diabetes education or pharmacological treatment within 1 month post-AMI. NDD was not associated with increased risk of worse short-term health status compared with risk noted for established diabetes.

Trial registration number

NCT00597922.
Candidate drug replacements for quinacrine in cutaneous lupus erythematosus
Authors: Yan Daisy , Borucki Robert , Sontheimer Richard D , Werth Victoria P
Published: October 2020

Cutaneous lupus erythematosus (CLE) is a disfiguring and potentially disabling disease that causes significant morbidity in patients. Antimalarials are an important class of medication used to treat this disease and have been the first-line systemic therapy since the 1950s. Quinacrine, in particular, is used as an adjuvant therapy to other antimalarials for improved control of CLE. Quinacrine is currently unavailable in the USA, which has taken away an important component of the treatment regimen of patients with CLE. This paper reviews the evidence of available local and systemic therapies in order to assist providers in choosing alternative treatments for patients who previously benefited from quinacrine therapy.
Republished: Interhospital teleproctoring of endovascular intracranial aneurysm treatment using a dedicated live-streaming technology: first experiences during the COVID-19 pandemic
Authors: Bechstein Matthias , Elsheikh Samer , Wodarg Fritz , Taschner Christian A , Hanning Uta , Buhk Jan-Hendrik , McDonough Rosalie , Goebell Einar , Fiehler Jens , Bester Maxim
Published: October 2020

This is a report of the first three cases of endovascular aneurysm treatment that were proctored by a remote interventionalist using a novel high-resolution low-latency streaming technology. The proctor was located in a neurovascular centre and supported the treating interventional teams in two distant cities (up to 800 km/500 miles apart). All aneurysms were treated using the Woven EndoBridge (WEB) embolisation system, either electively or following subarachnoid haemorrhage. On-site proctoring was not possible due to travel restrictions during the COVID-19 pandemic. WEB placement was feasible in all cases. Good rapport between proctors and treating physicians was reported, enabled by the high-resolution image transmission and uninterrupted feedback/discussion via audiostream. No clinical complications were encountered. Short-term follow-up revealed adequate occlusion of all treated aneurysms. The employed streaming technology provided effective remote proctoring during complex aneurysm cases, including the management of technical complications.
Long-term safety and efficacy of distal aneurysm treatment with flow diversion in the M2 segment of the middle cerebral artery and beyond
Authors: Cimflova Petra , Özlük Enes , Korkmazer Bora , Ahmadov Ramiz , Akpek Elif , Kizilkilic Osman , Islak Civan , Kocer Naci
Published: October 2020

Background

Indications for flow diversion stent (FDS) treatment are expanding. However, there is still a lack of evidence for the long-term outcome in distally located aneurysms in the M2 segment of the middle cerebral artery (MCA) and beyond.

Methods

Consecutive subjects (from June 2013 to August 2020) with MCA aneurysms in the M2 segment or beyond treated with FDS were reviewed retrospectively. The primary endpoints for clinical safety were the absence of mortality, stroke event, re-rupture of the aneurysm, and worsening of clinical symptoms. The primary endpoint for treatment efficacy was complete/near-complete occlusion at follow-up after 12 months.

Results

23 patients were identified: 7 aneurysms were located in the M2 segment of the MCA, 4 in the M2-M3 bifurcation, 2 in M3, 3 in M3-4 branching, and 2 in M4; 5 aneurysms were located in M2 with extension into the M1-M2 bifurcation. 13 aneurysms were of fusiform morphology, 8 sacculofusiform, and 2 saccular. 16 aneurysms were of highly suspected dissecting etiology. The median diameter of the parent vessel was 2.1 mm proximally and 2 mm distally. The median time of the follow-up was 30 months (range 16 months to 6 years). Complete/near complete occlusion was observed in 14/20 patients (70%) and one stable remodeling (5%) was seen at 12 months. 22 patients (95.6%) had an excellent clinical outcome (mRS 0–1) at 6 months. Technical challenges associated with the deployment of FDS occurred in 8.7% of cases. Severe complications, intraparenchymal hemorrhage and re-rupture of the aneurysm occurred in 2 patients (8.7%).

Conclusion

Flow diversion of distally located aneurysms is technically feasible with low morbidity and mortality.
Acute hyperaminoacidemia does not suppress insulin-mediated glucose turnover in healthy young men
Authors: Burgos Sergio A. , Chevalier Stéphanie , Morais José A. , Lamarche Marie , Kellett Samantha , Marliss Errol B.
Published: October 2020

Elevated circulating amino acids (AA) concentrations are purported to cause insulin resistance (IR) in humans. To quantify hyperaminoacidemia effects on insulin-mediated glucose turnover in healthy men, we performed 2-stage pancreatic clamps using octreotide with glucagon and growth hormone replacement. In the basal stage, insulin was infused to maintain euglycemia at postabsorptive levels. During the clamp stage, insulin was raised to postprandial levels, glycemia clamped at 5.5 mmol/L by glucose infusion, and branched-chain AA (BCAA) maintained at either postabsorptive (Hyper1; n = 8) or postprandial (Hyper2; n = 7) by AA infusion. Glucose turnover was measured by d-3-[3H]glucose dilution. Octreotide suppressed C-peptide; glucagon, growth hormone, and glycemia were maintained at postabsorptive levels throughout. Insulin did not differ at postabsorptive (72 ± 5 vs. 60 ± 5 pmol/L; Hyper1 vs. Hyper2) and increased to similar concentrations at basal (108 ± 11 vs. 106 ± 14) and clamp stages (551 ± 23 vs. 540 ± 25). Postabsorptive BCAA were maintained during Hyper1 and increased >2-fold (830 ± 26 µmol/L) during Hyper2. Endogenous glucose production was similarly suppressed (0.95 ± 0.16 vs. 1.37 ± 0.23 mg/kg lean body mass/min; Hyper1 vs. Hyper2) and basal glucose disposal (3.44 ± 0.12 vs. 3.67 ± 0.14) increased to similar levels (10.89 ± 0.56 vs. 11.11 ± 1.00) during the clamp. Thus, acute physiological elevation of AA for 3 h did not cause IR in healthy men.

Novelty: A 2-step pancreatic clamp was used to quantify the effect of AA on insulin sensitivity in humans. Acute physiological elevation of circulating AA to postprandial levels does not cause IR in healthy men.
Computational investigation of the reaction of nickel-bis(dithiolene) and nickel-bis(diselenolene) complexes with OH
Authors: Zhang Wenyuan , Lee Changmin , Bushnell Eric A.C.
Published: October 2020

In the present study, the reactivity of OH with Ni(X2C2H2)2 and Ni(X2C2H2)2 – (where X = S or Se) was investigated. From the thermodynamics, it found that the OH radical attacks a backbone C atom of the Ni(S2C2H2)2 complex. For the Ni(Se2C2H2)2 complex, the OH is predicted to target the ligating chalcogen atom. The significance of this is that with the attack of OH to a backbone C atom, the thermodynamic cost to lose a proton or hydrogen atom ranges from exergonic to marginally endergonic depending on the oxidation state of the complex. Notably, such a process results in a rearrangement of the complex, likely leading to deactivation of the catalyst. Where OH has attacked a ligating chalcogenide atom, the thermodynamic cost to lose a proton or hydrogen is endergonic regardless of oxidation state of the complex. Where OH attacks a coordinating chalcogenide atom, the thermodynamics for the addition of a proton was considered. At the present level of theory, it was found that for the dithiolene and diselenolene monoanionic complexes, the addition of a proton is marginally endergonic. However, following protonation, the loss of water is significantly exergonic and results in the regeneration of the neutral non-oxidized Ni complex. Given the greater tendency for OH to attack Se versus S, it may be speculated that the use of diselenolene ligands may offer a means to protect the Ni complex from damaging OH radicals due to the thermodynamic tendency for OH to attack Se atom of the diselenolene complexes not seen in the dithiolene complexes.
Factors influencing the structure of macroinvertebrate communities in subarctic lakes affected by wildfires
Authors: Pretty Thomas J. , Chanyi Charles-Matthew , Kuhn Catherine , Gray Derek K.
Published: October 2020

Fires are a natural phenomenon in the boreal forest, but their frequency is expected to increase over the coming century. Fires may affect water quality and invertebrates in lakes, but there have been few studies in the northern boreal forest to describe these impacts. We collected data on water quality, macrophytes, and invertebrates from 20 lakes in the Sahtú Settlement Area of the Northwest Territories. Nine lakes were affected by fires in their catchments 4–5 years before data collection, while eleven were not. Our results showed that few water quality variables were associated with fires. However, remote sensing and field observations suggested that macrophyte biomass was higher in lakes affected by burns, and this variable was a significant predictor of invertebrate composition. Burn history was an important predictor of the richness and abundance of invertebrates, but natural variability in lake properties was more important for explaining differences among lakes. Our results suggest that a better understanding of the effects of wildfires might be gained by examining how postfire changes in macrophytes affect other trophic levels.
Inhomogeneous compact extra dimensions and de Sitter cosmology
Authors: Bronnikov Kirill A. , Popov Arkady A. , Rubin Sergey G.
Published: October 2020

In the framework of multidimensional f(R) gravity, we study the possible metrics of compact extra dimensions assuming that our 4D space has the de Sitter metric. Manifolds described by such metrics could be formed at the inflationary and even higher energy scales. It is shown that in the presence of a scalar field, it is possible to obtain a variety of inhomogeneous metrics in the extra factor space $${{\mathbb {M}}}_2$$

M
2

. Each of these metrics leads to a certain value of the 4D cosmological constant $$\varLambda _4$$

Λ
4

, and in particular, it is possible to obtain $$\varLambda _4 =0$$

Λ
4

=
0

, as is confirmed by numerically obtained solutions. A nontrivial scalar field distribution in the extra dimensions is an important feature of this family of metrics. The obtained solutions are shown to be stable under extra-dimensional perturbations.
Mutually unbiased unextendible maximally entangled bases in Cd ⊗ Cq(d+1)
Authors: Tang Liang , Xiang Yi , Mo Zhi-Wen , Bai Ming-Qiang
Published: October 2020

Quantum measurements based on mutually unbiased base (MUB) are commonly used in quantum information processing. Firstly, we construct two completed unextendible maximally entangled bases (UMEBs) in bipartite systems [Formula: see text]. Then, the sufficient and necessary conditions of these two UMEBs develop into MUB can be obtained. Finally, we present some UMEBs that are mutually unbiased in concrete bipartite systems. These results provide a method to construct the best measurement bases.
The Impact of Sentiment on Commodity Return and Volatility
Authors: Maghyereh Aktham , Abdoh Hussein , Al-Shboul Mohammad
Published: October 2020

This study empirically investigates the effect of investor sentiment on returns and volatility of eight commodities. The findings suggest that sentiment has a predictive power on these commodities’ return and volatility. Fundamentally, return and volatility are positively associated with sentiment, suggesting that investors in the commodity markets are irrational — entailing the existence of noise trading. The results confirm the prediction of the affect infusion model in which optimistic investors are willing to take more risks, thus, raising returns and volatility. Furthermore, sentiment has a significant asymmetrical impact on volatility, and negative sentiment has a significantly greater impact than positive sentiment.
Hamiltonian systems of Schrödinger equations with vanishing potentials
Authors: Toon E. , Ubilla P.
Published: October 2020

In this paper, by means of minimax techniques involving Cerami sequences, we prove the existence of at least one pair of positive solutions for a Hamiltonian system of Schrödinger equations in [Formula: see text] with potentials vanishing at infinity and subcritical nonlinearities which are superlinear at the origin and at infinity. We establish new estimates to prove the boundedness of a Cerami sequence.
Research status of the rare and precious metals’ Materials Genome Initiative
Authors: Zhou Ying , Gan Guoyou , Yi Jianhong , Lai Yumin , Wang Yingwu , Gao Jian , Wang Zhiping
Published: October 2020

The core philosophy of Materials Genome Initiative (MGI) is the transition of the way of new materials design from the traditional “trial-and-error” approach to the in-silico materials design approach which employs intensive computing and material informatics. In June 2011, President Barack Obama launched MGI alongside the Advanced Manufacturing Partnership to help businesses discover, develop and deploy new materials twice as fast. In this paper, the concept of rare and precious genome is presented first, followed by the progress of MGI. After that, we focus on the research status of the rare and precious metals’ MGI including the computational tools, the high-throughput experimental methodologies and the rare and precious metals database. We also introduce the application of MGI in the development of rare and precious metal materials, outline the remaining fundamental challenges and present an outlook on the future of the rare and precious metals’ MGI.
The 2019 P-MIG Student Survey report and capturing the undergraduate perspective of physiology programming
Authors: Rogers Jennifer , McFarland Jenny L. , Stanescu Claudia I. , Crosswhite Patrick L. , Crecelius Anne R.
Published: October 2020

The aim of the 2019 Student Survey was to inform the Physiology Majors Interest Group (P-MIG) of characteristics of undergraduates enrolled in physiology courses or degree programs from across the United States, to be used as one input source for the development of program-level guidelines. There were 1,389 participants from seven universities who completed the 2019 P-MIG Student Survey. Thirty-seven percent reported enrollment in a physiology/human physiology major; allied health-related programs were the second most common (24%). Sixty-one percent of respondents reported attending a community college, the majority of whom enrolled in one or more courses at a community college while in high school (44%). Of participants who reported transferring coursework from one institution to another, 72% reported coursework transferred as expected. Homeostasis and structure/function were the two core concepts common to the top rankings for self-reported mastery, the expectation to be remembered in 5 yr, and deemed to be career relevant. Survey respondents indicated high engagement in co-curricular activities, with 72% participating or planning to participate in job shadowing opportunities, followed by volunteering (57%) and internships (50%). Over one-half of all survey participants indicated they “strongly agree” that their coursework and undergraduate programming has prepared them for success in their field of study. While the majority of respondents were satisfied with the academic advising received, additional guidance with regard to career choices and non-coursework professional development opportunities may be beneficial. Taken together, the collective data provides information from current physiology students that may inform development of consensus guidelines regarding curriculum, professional skills, and advising for undergraduate physiology degree programs.
PLOD1 Is a Prognostic Biomarker and Mediator of Proliferation and Invasion in Osteosarcoma
Authors: Jiang Haoli , Guo Wei , Yuan Shanyou , Song Lixia
Published: October 2020

Objective. Osteosarcoma is the most common primary bone tumor and most frequently develops during adolescence. PLOD family was mainly involved in lysyl hydroxylation and rarely investigated in cancers, especially in osteosarcoma. The aim of this study was to investigate the expression pattern and oncogenic role of PLODs in osteosarcoma. Methods. GEO datasets (GSE16088, GSE33382, and GSE16091) and validation cohort were used to analyze the expression pattern of PLODs in osteosarcoma. Kaplan‐Meier survival analysis was used to explore the prognostic role of PLODs in patients with osteosarcoma. RNA interference of KRT19 was performed using small interfering RNA (siRNA) in MG‐63 and U‐2OS cells. The proliferation was detected using CCK8, clone formation assay, and EdU staining. Migration and invasion were determined using the transwell assay. Western blots and luciferase assays for β‐catenin‐T‐cell factor protein/β‐catenin‐lymphoid enhancer factor‐ (β‐catenin‐TCF/LEF‐) driven transcriptional activity. Results. PLOD1 was upregulated in osteosarcoma tissues compared with control tissues both in public datasets and in in‐house cohort. The expression of PLOD1 in osteosarcoma tissues was significantly associated with the status of distance metastasis and Enneking stage, while PLOD2 and PLOD3 expressed no difference between osteosarcoma and benign tissues and showed no correlation with tumor malignancy. Furthermore, Kaplan‐Meier survival analysis revealed that patients with a higher level of PLOD1 had worse prognosis than those with a lower level of PLOD1. Downregulation of PLOD1 dramatically inhibited proliferation, migration, and invasion of MG‐63 cells and U‐2OS cells in vitro. Mechanistically, PLOD1 regulated β‐catenin signaling pathway in osteosarcoma. Conclusion. Our results indicated that PLOD1 promoted proliferation, migration, and invasion of osteosarcoma cells. PLOD1 was a novel prognostic marker, as well as a therapeutic target in osteosarcoma.
COVID-19 Epidemic in Sri Lanka: A Mathematical and Computational Modelling Approach to Control
Authors: Wickramaarachchi W. P. T. M. , Perera S. S. N. , Jayasinghe S.
Published: October 2020

The ongoing COVID-19 outbreak that originated in the city of Wuhan, China, has caused a significant damage to the world population and the global economy. It has claimed more than 0.8 million lives worldwide, and more than 27 million people have been infected as of 07th September 2020. In Sri Lanka, the first case of COVID-19 was reported late January 2020 which was a Chinese national and the first local case was identified in the second week of March. Since then, the government of Sri Lanka introduced various sequential measures to improve social distancing such as closure of schools and education institutes, introducing work from home model to reduce the public gathering, introducing travel bans to international arrivals, and more drastically, imposed island wide curfew expecting to minimize the burden of the disease to the Sri Lankan health system and the entire community. Currently, there are 3123 cases with 12 fatalities and also, it was reported that 2925 patients have recovered and are discharged from hospitals, according to the Ministry of Health, Sri Lanka. In this study, we use the SEIR conceptual model and its modified version by decomposing infected patients into two classes: patients who show mild symptoms and patients who tend to face severe respiratory problems and are required to be treated in intensive care units. We numerically simulate the models for about a five-month period reflecting the early stage of the epidemic in the country, considering three critical parameters of COVID-19 transmission mainly in the Sri Lankan context: efficacy of control measures, rate of overseas imported cases, and time to introduce social distancing measures by the respective authorities.
Performance Evaluation of Diagnostic Methods for Schistosoma mansoni Detection in Amhara Region, Northwest Ethiopia
Authors: Fenta Abebe , Hailu Tadesse , Alemu Megbaru , Amor Arancha
Published: October 2020

Background. Schistosoma mansoni is a parasitic worm that infects humans throughout the world. It is more prevalent in sub‐Saharan Africa including Ethiopia. Proper detection of Schistosoma mansoni using sensitive diagnostic methods is crucial in the prevention and control era. Since direct wet mount microscopy with its low sensitivity has been used as a diagnostic technique in Ethiopia, searching alternative diagnostic methods which have better sensitivity should be a priority agenda. Objective. This study is aimed at evaluating the performance of diagnostic methods for Schistosoma mansoni in Amhara region. Methods. A cross‐sectional study was conducted among 520 school children from October to December 2019 in Amhara region. The study participants were selected by a systematic random sampling technique. Stool samples were collected from each participant and processed via formol‐ether concentration, Kato‐Katz, and spontaneous tube sedimentation techniques. The data was entered into EpiData version 3.1, and analysis was done using SPSS version 20. The sensitivity, specificity, positive predictive value, and negative predictive value were calculated against the combined result as “Gold” standard. A kappa value was computed to measure the strength of agreement of the diagnostic methods. Results. The overall prevalence of Schistosoma mansoni was 20.2% using a combination of three methods. The prevalence of 8.3%, 12.9%, and16.3%, respectively, was recorded by using formol‐ether concentration, Kato‐Katz, and spontaneous tube sedimentation. The spontaneous tube sedimentation method (81.0%) had better sensitivity compared to Kato‐Katz (63.8%) and formol‐ether concentration (41.0%) methods in Schistosoma mansoni detection. Conclusion. The spontaneous tube sedimentation technique is more sensitive and has better detection rate to Schistosoma mansoni infection followed by the Kato‐Katz technique. Therefore, updating the current diagnostic methods for Schistosoma mansoni could be a priority agenda to take action in schistosomiasis prevention and control.
Poor COVID-19 Preventive Practice among Healthcare Workers in Northwest Ethiopia, 2020
Authors: Kassie Belayneh Ayanaw , Adane Aynishet , Abebe Kassahun Eskeziaw , Ayele Amare Simegn , Kassahun Belew Aysheshim
Published: October 2020

Background. The novel coronavirus disease (COVID-19) pandemic outbreak affects the global social, economic, and political context and becomes a significant threat to healthcare providers who are among the exposed groups to acquire and transmit the disease while caring and treating patients. It is crucial to comply with prevention recommendations so as to stay safe and protected. Therefore, this study aimed to assess COVID-19 preventive practice and associated factors among healthcare workers in Northwest Ethiopia. Methods. An institution-based cross-sectional study was conducted among 630 healthcare workers in Northwest Ethiopia from March to April 2020. A multistage sampling technique was used to select study participants. A pretested and structured self-administered questionnaire was used to collect data. The data were entered using Epi Info 7 and analyzed using STATA 16 statistical software. Both bivariate and multivariable logistic regression analyses were employed to identify associated factors. Adjusted odds ratio (AOR) with 95% confidence interval was used to determine independent predictors of COVID-19 preventive practice. In multivariable analysis, a variable with a

P

value of less than 0.05 was considered as statically significant. Result. Among 630 healthcare workers participated in the study, the overall good preventive practice towards COVID-19 was found to be 38.73% (95% CI: 34.8, 42.5). Being a male healthcare provider (AOR = 1.48; 95% CI: 1.02, 2.10), having work experience of 6–10 years (AOR = 2.22; 95% CI: 1.23, 4.00), and having poor attitude towards COVID-19 (AOR = 2.22; 95% CI: 1.03, 2.22) were found to be significantly associated with poor COVID-19 preventive practice among healthcare workers. Conclusion. Overall compliance towards COVID-19 preventive practice among healthcare workers was found to be low. Multiple education and training platforms with focus on COVID-19 preventive measures and adequate personal protective equipment and supplies should be provided for healthcare providers.
The Protective Effects and Potential Mechanisms of Ligusticum chuanxiong: Focus on Anti‐Inflammatory, Antioxidant, and Antiapoptotic Activities
Authors: Shi Jinhui , Li Ruiyue , Yang Siyu , Phang Yeelin , Zheng Changwu , Zhang Hongmei
Published: October 2020

Ligusticum chuanxiong (LC) is a Chinese materia medica which is widely used in clinical settings to treat headaches, blood extravasation, and arthritis. Recent studies demonstrate that LC possesses versatile pharmacological functions, including antiatherosclerosis, antimigraine, antiaging, and anticancer properties. Moreover, LC also shows protective effects in the progression of different diseases that damage somatic cells. Oxidative stress and inflammation, which can induce somatic cell apoptosis, are the main factors associated with an abundance of diseases, whose progresses can be reversed by LC. In order to comprehensively review the molecular mechanisms associated with the protective effects of LC, we collected and integrated all its related studies on the anti‐inflammatory, antioxidant, and antiapoptotic effects. The results show that LC could exhibit the mentioned biological activities by modulating several signaling pathways, specifically the NF‐κB, Nrf2, protein kinase, and caspase‐3 pathways. In future investigations, the pharmacokinetic properties of bioactive compounds in LC and the signaling pathway modulation of LC could be focused.
Synchronized Chaos of a Three-Dimensional System with Quadratic Terms
Authors: Allahem Ali
Published: October 2020

In this paper, a novel chaotic new three-dimensional system has been studied by Zhang et al. in 2012. In the system, there are three control parameters and three different nonlinear terms which governed equations. Zhang et al. studied elementary (preliminary) dynamic properties of the chaotic new three-dimensional system by means of bifurcation diagram, maximum Lyapunov exponent, phase portraits, dynamics behaviors by changing some parameters etc., using all possible theoretical analysis and numerical simulation. In this paper, we have demonstrated its complete synchronization. The proposed results are verified by numerical simulations.
Hybrid Solution for Mycotic Pseudoaneurysm of Carotid Bifurcation
Authors: Deiana Giuseppe , Baule Antonio , Georgiev Genadi Genadiev , Moro Mario , Spanu Francesco , Urru Flavia , Camparini Stefano
Published: October 2020

Mycotic pseudoaneurysms of the extracranial carotid artery are rare and need surgical treatment to prevent rupture or embolization. We treated a case of a carotid bifurcation pseudoaneurysm secondary to infection caused by Staphylococcus epidermidis. We successfully treated it using a catheter balloon to obtain carotid bifurcation’s control and replacing the carotid bifurcation with a vein graft. Management involves aneurysmectomy associated with antibiotic therapy and restoration of arterial continuity.
Personality Differences of Brain Networks in Placebo Analgesia and Nocebo Hyperalgesia: A Psychophysiological Interaction (PPI) Approach in fMRI
Authors: Shi Yu , Huang Shimin , Zhan Hongrui , Wang Yaping , Zeng Yanyan , Cai Guiyuan , Yang Jianming , Wu Wen
Published: October 2020

It is generally believed that the placebo response can elicit an analgesic effect, whilst the nocebo response can elicit a hyperalgesia effect in pain. Placebo analgesia and nocebo hyperalgesia effects are increasing concerns for researchers. Growing evidence suggests personality differences have an impact on both placebo and nocebo effects. However, previous studies have not reached a unified conclusion. We designed this study to explore the personality differences of functional magnetic resonance imaging (fMRI) signals in placebo response and nocebo response by using psychophysiological interaction (PPI) analysis. 30 healthy subjects underwent conditioning induction training to establish expectations of placebo effect and nocebo effect, and then, all subjects completed the following experimental procedures: (1) baseline scanning, (2) acute pain model establishment, (3) pain status scanning, and (4) pseudorandom scanning of block design of placebo response or nocebo response. Behavioral data were collected after each scan. The results of this study showed that (1) there were significant differences of VAS placebo intervention between the extrovert group and the introvert group (p=0.004); (2) there were significant differences of VAS nocebo intervention between the extrovert group and the introvert group (p=0.011); (3) there were significant differences between the VAS placebo intervention and VAS pain status (baseline) in both the extrovert group (p<0.001) and the introvert group (p=0.001); (4) there were significant differences between the VAS nocebo intervention and VAS pain status (baseline) in both the extrovert group (p=0.008) and the introvert group (p<0.001). Moreover, there were significant differences in the brain network for placebo and nocebo responses between different personalities. We found that (1) deactivation differences of the pain-related network and limbic system play an important role in personality differences associated with placebo analgesia and (2) differences of control of anxiety and activation of dorsolateral prefrontal cortex may cause the personality differences observed in nocebo hyperalgesia.
Monolithic and Minimally Veneered Zirconia Complications as Implant‐Supported Restorative Material: A Retrospective Clinical Study up to 5 Years
Authors: Diéguez-Pereira Markel , Chávarri-Prado David , Estrada-Martínez Alejandro , Pérez-Pevida Esteban , Brizuela-Velasco Aritza
Published: October 2020

Objective. Long‐term clinical data on the success and complication rates of monolithic or minimally veneered zirconia implant‐supported restorations are lacking. Hence, the purpose of this retrospective clinical study was to analyze the complications of monolithic or partially veneered zirconia implant‐supported restorations up to 5 years follow‐up. Material and Methods. Single crowns, bridges, and full‐arch rehabilitations were included. The selection process was achieved by reviewing data from the prosthetic laboratory and excluding cases in which zirconium and full‐ceramic coating restorations were used. A total of 154 restorations were included (82 monolithic and 72 with buccal ceramic stratification). All the complications encountered, and the solutions applied, were explained. Results. A total of 93 restorative units had a follow‐up of between 24 and 60 months, and 61 restoration units had a follow‐up of between 12 and 24 months. A total of 7 complications were encountered (14.58% of cases; 95.45% per prosthetic unit). The technical complication rate was 2.08% (one case of minor chipping in one prosthetic unit); regarding the mechanical complications, four decementations (8.33% of the cases) and two screw loosening (4.17% of the cases) were encountered. Conclusions. Considering the limitations of this study, it can be concluded that monolithic or partially veneered zirconia implant‐supported restorations have a good clinical behavior during a follow‐up period of up to 5 years.
Study on Mechanical Failure and PermeabilityCharacteristicsof Porous Gas-Bearing Coal under Triaxial Stress
Authors: Zhang Xue-bo , Wang Wen-yuan , Yang Ming , Cai Hang-hang , Liu Jia-jia , Shen Shuai-shuai
Published: October 2020

To explore the mechanical failure and permeability characteristics of porous gas-bearing coal under triaxial stress, the triaxial compression experiment was carried out for porous and conventional gas-bearing coal samples based on the triaxial creep-seepage experiment system and sound emission signal acquisition system. Acoustic emission testing was carried out at the same time of loading failure. The experimental results showed that (1) under fixed gas pressure but changing confining pressure, the porous gas-bearing coal sample had higher peak strength and elastic modulus but lower peak strain; under changing gas pressure but fixed confining pressure, the porous gas-bearing coal sample had lower peak strength and peak strain but higher elastic modulus. When either confining pressure or gas pressure was changed, the mechanical properties of the two kinds of gas-bearing coal samples showed a good consistency, but the mechanical parameters differed greatly, with the peak strength, peak strain, and elastic modulus of porous coal samples are reduced by 1/4, 2/3, and 3/4, respectively. (2) When either the confining pressure or gas pressure was changed, the permeability of the porous gas-bearing coal sample was larger than that of the conventional gas-bearing coal sample. However, the change rules of permeability characteristics of the two were basically the same, except that there was a large difference in permeability value that the porous gas-bearing coal sample increases nearly twice as much as that of the conventional gas-bearing coal sample. (3) In the whole stress-strain process, the acoustic emission characteristics of the porous gas-bearing coal sample differed significantly from those of the conventional gas-bearing coal sample. The maximum ringdown count of the porous gas-bearing coal sample can be reduced by one-third at most, the maximum energy can be reduced by nearly half at most, and the maximum amplitude changes little with only 1–3 dB reduction. The research results have important guiding significance for the prediction of failure and instability of coal tunnel and the development of relevant protective techniques.
Rolling Bearing Fault Diagnosis Using a Deep Convolutional Autoencoding Network and Improved Gustafson–Kessel Clustering
Authors: Wu Yaochun , Zhao Rongzhen , Jin Wuyin , Deng Linfeng , He Tianjing , Ma Sencai
Published: October 2020

Deep learning (DL) has been successfully used in fault diagnosis. Training deep neural networks, such as convolutional neural networks (CNNs), require plenty of labeled samples. However, in mechanical fault diagnosis, labeled data are costly and time-consuming to collect. A novel method based on a deep convolutional autoencoding network (DCAEN) and adaptive nonparametric weighted-feature extraction Gustafson–Kessel (ANW-GK) clustering algorithm was developed for the fault diagnosis of bearings. First, the DCAEN that is pretrained layer by layer by unlabeled samples and fine-tuned by a few labeled samples is applied to learn representative features from the vibration signals. Then, the learned representative features are reduced by t-distributed stochastic neighbor embedding (t-SNE), and the low-dimensional main features are obtained. Finally, the low-dimensional features are input ANW-GK clustering for fault identification. Two datasets were used to validate the effectiveness of the proposed method. The experimental results show that the proposed method can effectively diagnose different fault types with only a few labeled samples.
Evaluating the Role of Big Data in IIOT-Industrial Internet of Things for Executing Ranks Using the Analytic Network Process Approach
Authors: Liao Xiaoqun , Faisal Mohammad , QingChang Qing , Ali Amjad
Published: October 2020

Due to the enhancements of Internet of Things (IoT) and sensors deployments, the production of big data in Industrial Internet of Things (IIoT) is increased. The accessing and processing of big data become a challenging issue due to the limited storage space, computational time, networking, and IoT devices end. IoT and big data are well thought-out to be the key concepts when describing new information architecture projects. The techniques, tools, and methods that help to provide better solutions for IoT and big data can have an important role to play in the architecture of business. Different approaches are being practiced in the literature for evaluating the role of big data in IIoT. These techniques are not handling the situations when complexity of dependency arises among parameters of the alternatives. The proposed research uses the approach of Analytic Network Process (ANP) for evaluating the role of big data in IIoT. The results show that the proposed research works well for evaluating the role of big data in IIoT.
UPLC‐MS/MS Method for the Simultaneous Quantification of Eight Compounds in Rat Plasma and Its Application to a Pharmacokinetic Study after Oral Administration of Veratrum (Veratrum nigrum L.) Extract
Authors: Fan Yuqi , Zhao Lulu , Huang Xuhua , Shen Jiayuan , Wang Wei , Jia Xiaohua , Gao Mengyuan , Ouyang Huizi , Chang Yanxu , He Jun
Published: October 2020

Veratrum nigrum L. is a well‐known traditional Chinese medicine with a lot of pharmacological activities including antihypertensive, anticancer, and antifungal effects. In the current experiment, a rapid and sensitive UPLC‐MS/MS method that takes only 7 min run time has been established and validated for simultaneous determination of eight bioactive compounds including cyclopamine, jervine, veratramine, polydatin, quercetin, apigenin, resveratrol, and veratrosine in rat plasma. The chromatographic separation of analytes and internal standard was performed on a Phenyl‐Hexyl column (2.1 × 100 mm, 1.7 μm) with the mobile phase consisting of water (0.1% formic acid) and acetonitrile at a flow rate of 0.3 mL/min. An electrospray ionization (ESI) source was used to detect the samples in both positive and negative ion modes. The intra‐ and interday precisions of the compounds were less than 9.5% and the accuracy ranged from ‐10.8% to 10.4%. The extraction recoveries of the compounds were in the range of 85.1 ± 1.5% to 102.6 ± 8.0%, and the matrix effect ranged from 91.2 ± 4.5% to 113.8 ± 1.5%. According to the results of the stability test, the eight compounds have good stability under various conditions and the relative standard deviation (RSD) less than 13.2%. The pharmacokinetic parameters of the eight compounds in rat plasma after oral administration of Veratrum nigrum L. extract were successfully determined by the established UPLC‐MS/MS method.
Soluble Receptor for Advanced Glycation End-products (sRAGE) and Colorectal Cancer Risk: A Case–Control Study Nested within a European Prospective Cohort
Authors: Aglago Elom K. , Rinaldi Sabina , Freisling Heinz , Jiao Li , Hughes David J. , Fedirko Veronika , Schalkwijk Casper G. , Weiderpass Elisabete , Dahm Christina C. , Overvad Kim , Eriksen Anne Kirstine , Kyrø Cecilie , Boutron-Ruault Marie-Christine , Rothwell Joseph A. , Severi Gianluca , Katzke Verena , Kühn Tilman , Schulze Matthias B. , Aleksandrova Krasimira , Masala Giovanna , Krogh Vittorio , Panico Salvatore , Tumino Rosario , Naccarati Alessio , Bueno-de-Mesquita Bas , van Gils Carla H. , Sandanger Torkjel M. , Gram Inger T. , Skeie Guri , Quirós J. Ramón , Jakszyn Paula , Sánchez Maria-Jose , Amiano Pilar , Huerta José María , Ardanaz Eva , Johansson Ingegerd , Harlid Sophia , Perez-Cornago Aurora , Mayén Ana-Lucia , Cordova Reynalda , Gunter Marc J. , Vineis Paolo , Cross Amanda J. , Riboli Elio , Jenab Mazda
Published: October 2020

Background:

Overexpression of the receptor for advanced glycation end-product (RAGE) has been associated with chronic inflammation, which in turn has been associated with increased colorectal cancer risk. Soluble RAGE (sRAGE) competes with RAGE to bind its ligands, thus potentially preventing RAGE-induced inflammation.

Methods:

To investigate whether sRAGE and related genetic variants are associated with colorectal cancer risk, we conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Plasma sRAGE concentrations were measured by ELISA in 1,361 colorectal cancer matched case–control sets. Twenty-four SNPs encoded in the genes associated with sRAGE concentrations were available for 1,985 colorectal cancer cases and 2,220 controls. Multivariable adjusted ORs and 95% confidence intervals (CIs) were computed using conditional and unconditional logistic regression for colorectal cancer risk and circulating sRAGE and SNPs, respectively.

Results:

Higher sRAGE concentrations were inversely associated with colorectal cancer (ORQ5vs.Q1, 0.77; 95% CI, 0.59–1.00). Sex-specific analyses revealed that the observed inverse risk association was restricted to men (ORQ5vs.Q1, 0.63; 95% CI, 0.42–0.94), whereas no association was observed in women (ORQ5vs.Q1, 1.00; 95% CI, 0.68–1.48; Pheterogeneity for sex = 0.006). Participants carrying minor allele of rs653765 (promoter region of ADAM10) had lower colorectal cancer risk (C vs. T, OR, 0.90; 95% CI, 0.82–0.99).

Conclusions:

Prediagnostic sRAGE concentrations were inversely associated with colorectal cancer risk in men, but not in women. An SNP located within ADAM10 gene, pertaining to RAGE shedding, was associated with colorectal cancer risk.

Impact:

Further studies are needed to confirm our observed sex difference in the association and better explore the potential involvement of genetic variants of sRAGE in colorectal cancer development.
HIV Protease Inhibitors Block HPV16-Induced Murine Cervical Carcinoma and Promote Vessel Normalization in Association with MMP-9 Inhibition and TIMP-3 Induction
Authors: Qiu Yaqi , Maione Federica , Capano Stefania , Meda Claudia , Picconi Orietta , Brundu Serena , Pisacane Alberto , Sapino Anna , Palladino Clelia , Barillari Giovanni , Monini Paolo , Bussolino Federico , Ensoli Barbara , Sgadari Cecilia , Giraudo Enrico
Published: October 2020

Antiretrovirals belonging to the human immunodeficiency virus (HIV) protease inhibitor (HIV-PI) class exert inhibitory effects across several cancer types by targeting tumor cells and its microenvironment. Cervical carcinoma represents a leading cause of morbidity and mortality, particularly in women doubly infected with high-risk human papillomaviruses (HR-HPV) and HIV; of note, combined antiretroviral therapy has reduced cervical carcinoma onset and progression in HIV-infected women. We evaluated the effectiveness and mechanism(s) of action of HIV-PI against cervical carcinoma using a transgenic model of HR-HPV–induced estrogen-promoted cervical carcinoma (HPV16/E2) and found that treatment of mice with ritonavir-boosted HIV-PI, including indinavir, saquinavir, and lopinavir, blocked the growth and promoted the regression of murine cervical carcinoma. This was associated with inhibition of tumor angiogenesis, coupled to downregulation of matrix metalloproteinase (MMP)-9, reduction of VEGF/VEGFR2 complex, and concomitant upregulation of tissue inhibitor of metalloproteinase-3 (TIMP-3). HIV-PI also promoted deposition of collagen IV at the epithelial and vascular basement membrane and normalization of both vessel architecture and functionality. In agreement with this, HIV-PI reduced tumor hypoxia and enhanced the delivery and antitumor activity of conventional chemotherapy. Remarkably, TIMP-3 expression gradually decreased during progression of human dysplastic lesions into cervical carcinoma. This study identified the MMP-9/VEGF proangiogenic axis and its modulation by TIMP-3 as novel HIV-PI targets for the blockade of cervical intraepithelial neoplasia/cervical carcinoma development and invasiveness and the normalization of tumor vessel functions. These findings may lead to new therapeutic indications of HIV-PI to treat cervical carcinoma and other tumors in either HIV-infected or uninfected patients.
Postural Stability in Obese Preoperative Bariatric Patients Using Static and Dynamic Evaluation
Authors: Pagnotti Gabriel M. , Haider Amna , Yang Ariel , Cottell Kathryn E. , Tuppo Catherine M. , Tong Kai-Yu , Pryor Aurora D. , Rubin Clinton T. , Chan M. Ete
Published: October 2020

Introduction: Globally, 300 million adults have clinical obesity. Heightened adiposity and inadequate musculature secondary to obesity alter bipedal stance and gait, diminish musculoskeletal tissue quality, and compromise neuromuscular feedback; these physiological changes alter stability and increase injury risk from falls. Studies in the field focus on obese patients across a broad range of body mass indices (BMI >30 kg/m2) but without isolating the most morbidly obese subset (BMI ≥40 kg/m2). We investigated the impact of obesity in perturbing postural stability in morbidly obese subjects elected for bariatric intervention, harboring a higher-spectrum BMI. Subjects and Methods: Traditional force plate measurements and stabilograms are gold standards employed when measuring center of pressure (COP) and postural sway. To quantify the extent of postural instability in subjects with obesity before bariatric surgery, we assessed 17 obese subjects with an average BMI of 40 kg/m2 in contrast to 13 nonobese subjects with an average BMI of 30 kg/m2. COP and postural sway were measured from static and dynamic tasks. Involuntary movements were measured when patients performed static stances, with eyes either opened or closed. Two additional voluntary movements were measured when subjects performed dynamic, upper torso tasks with eyes opened. Results: Mean body weight was 85% (p < 0.001) greater in obese than nonobese subjects. Following static balance assessments, we observed greater sway displacement in the anteroposterior (AP) direction in obese subjects with eyes open (87%, p < 0.002) and eyes closed (76%, p = 0.04) versus nonobese subjects. Obese subjects also exhibited a higher COP velocity in static tests when subjects’ eyes were open (47%, p = 0.04). Dynamic tests demonstrated no differences between groups in sway displacement in either direction; however, COP velocity in the mediolateral (ML) direction was reduced (31%, p < 0.02) in obese subjects while voluntarily swaying in the AP direction, but increased in the same cohort when swaying in the ML direction (40%, p < 0.04). Discussion and Conclusion: Importantly, these data highlight obesity’s contribution towards increased postural instability. Obese subjects exhibited greater COP displacement at higher AP velocities versus nonobese subjects, suggesting that clinically obese individuals show greater instability than nonobese subjects. Identifying factors contributory to instability could encourage patient-specific physical therapies and presurgical measures to mitigate instability and monitor postsurgical balance improvements.