bluuebunny/crossref_metadata_2025 huggingface dataset:
Closed-Loop Behavior of an Autonomous Helicopter Equipped with a Robotic Arm for Aerial Manipulation Tasks
Authors: Kondak Konstantin , Krieger Kai , Albu-Schaeffer Alin , Schwarzbach Marc , Laiacker Maximilian , Maza Ivan , Rodriguez-Castano Angel , Ollero Anibal
Published: March 2013

This paper is devoted to the control of aerial robots interacting physically with objects in the environment and with other aerial robots. The paper presents a controller for the particular case of a small-scaled autonomous helicopter equipped with a robotic arm for aerial manipulation. Two types of influences are imposed on the helicopter from a manipulator: coherent and non-coherent influence. In the former case, the forces and torques imposed on the helicopter by the manipulator change with frequencies close to those of the helicopter movement. The paper shows that even small interaction forces imposed on the fuselage periodically in proper phase could yield to low frequency instabilities and oscillations, so-called phase circles.
Strengthening of a Fibre-Matrix Interface: A Novel Method Using Nanoparticles
Authors: Tiwari Sudhir , Bijwe J. , Panier S.
Published: March 2013

The surface of carbon fabric (CF) was treated with nanoparticles (NPs) of Ytterbium fluoride (YbF3) (40–80nm size) in various amounts (0, 0.1, 0.3 and 0.5wt%) to improve its wettability with a Polyetherimide (PEI) matrix. The effect of treatment on the fibres of the CF was also studied by adhesion testing and fibre tow tension testing. An improvement in wettability with PEI and a slight reduction in the tensile strength of the CF was observed in these tests. Fourier transform infrared-attenuated total reflectance spectroscopy (FTIR-ATR) indicated the addition of functional groups on the fabric after treatment. Micro-Raman spectroscopy (MRS) showed a slight distortion in the structure of the CF due to the treatment. Increased roughness of the fibre surface and adhesion of NPs on the fibre surface were observed by field emission scanning electron microscopy (FESEM). Composites were developed based on untreated and surface-treated CFs by impregnation techniques. The composites were analysed for interlaminar shear strength (ILSS) and a maximum improvement of 61% was observed for the 0.3% concentration of YbF3, followed by a slight decline in ILSS, indicating that it was the optimum dose.
Undifferentiated Endometrial Carcinoma: A Diagnosis Frequently Overlooked
Authors: Al-Loh Shaymaa , Al-Hussaini Maysa
Published: March 2013

Undifferentiated endometrial carcinoma (UEC) is a relatively uncommon neoplasm with only few studies published thus far. It has always been a diagnostic challenge because of the lack of proper definition cited in most of the standard textbooks. Recently however, a few studies have highlighted the clinicopathologic features of UEC. The distinctive morphology of UEC was noted by the group from MD Anderson Cancer Center, which enabled them to establish the defining criteria. It appears to be more aggressive than endometrial endometrioid adenocarcinoma, FIGO (International Federation of Gynecology and Obstetrics) grade 3, its main differential diagnosis. Proper recognition of this entity is important owing to its aggressive behavior.
Making the Diagnosis of Frontotemporal Lobar Degeneration
Authors: Bigio Eileen H.
Published: March 2013

Context.—Autopsy evaluation of the brain of a patient with frontotemporal dementia (FTD) can be daunting to the general pathologist. At some point in their training, most pathologists learn about Pick disease, and can recognize Pick bodies, the morphologic hallmark of Pick disease. Pick disease is a type of frontotemporal lobar degeneration (FTLD), the general category of pathologic process underlying most cases of FTD. The 2 major categories of pathologic FTLD are tauopathies (FTLD-tau) and ubiquitinopathies (FTLD-U). Pick disease is one of the FTLD-tau subtypes and is termed FTLD-tau (PiD).

Objective.—To “demystify” FTLDs, and to demonstrate that subtypes of FTLD-tau and FTLD-U can be easily determined by following a logical, stepwise, histochemical, and immunohistochemical investigation of the FTD autopsy brain.

Data Sources.—Previously published peer-reviewed articles.

Conclusions.—The hope is that this article will be a useful reference for the general pathologist faced with performing a brain autopsy on a decedent with frontotemporal dementia.
Primary Adenocarcinoma of the Urinary Bladder: Differential Diagnosis and Clinical Relevance
Authors: Zhong Minghao , Gersbach Elizabeth , Rohan Stephen M. , Yang Ximing J.
Published: March 2013

Context.—Glandular lesions of the urinary bladder include a broad spectrum of entities ranging from completely benign glandular lesions to primary and secondary malignancies. Common benign bladder lesions that exhibit glandular differentiation include cystitis cystica, cystitis glandularis, von Brunn nests, nephrogenic adenoma, intestinal metaplasia, urachal remnant, endometriosis, and prostatic-type polyp. The World Health Organization defines primary adenocarcinoma of the bladder as an epithelial malignancy with pure glandular differentiation without evidence of typical urothelial carcinoma. Malignant lesions that should be included in the differential diagnosis of a primary adenocarcinoma of the bladder include noninvasive and invasive urothelial carcinoma with glandular differentiation and secondary malignancies involving the bladder by direct extension or metastasis. The recognition and distinction of these different entities may be a challenge for pathologists, but they are of great clinical importance.

Objective.—To review features of primary bladder adenocarcinoma as well as those entities that need to be differentiated from primary bladder adenocarcinoma, with emphasis on clinical findings, pathologic characteristics, and immunoprofiles.

Data Sources.—Selected original articles published in the PubMed service of the US National Library of Medicine.

Conclusions.—The accurate diagnosis of adenocarcinoma of the urinary bladder is important and challenging. It has to prompt an extensive clinical workup to rule out other glandular lesions in the urinary bladder, especially the possibility of secondary involvement of the bladder by an adenocarcinoma from a different site.
Identification of Organic Compounds in Solid Aerosols Related to Faisalabad Environment Using XRD Technique
Authors: Muhammad Attique Khan Shahid  , Khadim Hussain  , Ahmad Raza
Published: March 2013

Faisalabad is a big industrial city with huge air quality problems, being one of the most polluted cities in the world. Although public policies have developed to minimize atmospheric aerosol pollution, there is a lack of adequate knowledge and poor characterization of these aerosols. In this study we sampled 100 aerosol samples from different pools covering almost all the aspects of Faisalabad environment. The results obtained from an investigation of solid aerosols in the Industrial city of Faisalabad (Pakistan) are reported and analysed in this paper. X-ray diffraction studies of the va­rious solid aerosols pools (residential, industrial, transportational, commercial and mix pools) showed that non-clay organic compounds such as GB-Naphthylbismuth dioxide,Sodium hippurate, Sodium-GA-naphthylamine-4-sulfonate tetrahydrate, Potassium phenoxide, Bismuth salicylate, Cadmium salicylate hydrate, Barium phenolsulfonate are contained in most of the samples in almost comparable amounts.The results of Solid aerosols collected from various pools show that the sources of GB-Naphthylbismuth dioxide,Sodium hippurate, Sodium-GA-naphthylamine-4-sulfonate tetrahydrate, Potassium phenoxide, Bismuth salicylate, Cadmium salicylate hydrate, Barium phenolsulfonatein the Solid aerosols are both local and remote. No doubt the main objective of this study was not to investigate the human health hazards however; an attempt has been made to correlate health hazards on behalf of their size distribution.
Implantation of a Left Ventricular Assist Device with Mini-Pericardiotomy Technique
Authors: Balkanay Mehmet , Fedakar AM , Alsalehi Saleh , Rabus Murat Bülent
Published: March 2013

The left ventricular assist device may be a lifesaving therapy for a patient awaiting a heart transplant. The most common complications of this device are mediastinal bleeding, infections, embolic events, right-sided heart failure, and mediastinal adhesions. We are reporting a patient who had a Levitronix left ventricular assist device implanted with mini-pericardiotomy technique for bridging to heart transplant.
Risk Evaluation and Mitigation Strategies: A Focus on Belatacept
Authors: Sam Teena , Gabardi Steven , Tichy Eric M.
Published: March 2013

Objective

To review the elements and components of the risk evaluation and mitigation strategies (REMS) for the costimulation blocker belatacept and associated implications for health care providers working with transplant recipients.

Data Sources and Extraction

The MEDLINE and EMBASE databases (January 1990 to March 2012) were searched by using risk evaluation and mitigation strategies, REMS, belatacept, and organ transplant as search terms (individual organs were also searched). Retrieved articles were supplemented with analysis of information obtained from the Federal Register, the Food and Drug Administration, and the manufacturer of belatacept.

Data Synthesis

REMS are risk-management strategies implemented to ensure that a product's benefits outweigh its known safety risks. Although belatacept offers a novel strategy in maintenance immunosuppression and was associated with superior renal function compared with cyclosporine in phase 2 and 3 trials, belatacept is also associated with increased risk of posttransplant lymphoproliferative disorder and central nervous system infections. The Food and Drug Administration required development of a REMS program as part of belatacept's approval process to ensure safe and appropriate use of the medication and optimization of its risk-benefit profile. Conclusion—Elements of the belatacept REMS include a medication guide that must be dispensed with each infusion and a communication plan. In the management of a complex population of patients, it is essential that those who care for transplant recipients, and patients, recognize the implications of potential and known risks of belatacept. The REMS program aims to facilitate careful selection and education of patients and vigilant monitoring.
Aspergillus Galactomannan Antigen for Diagnosis and Treatment Monitoring in Cerebral Aspergillosis
Authors: Soeffker Gerold , Wichmann Dominic , Loderstaedt Ulrike , Sobottka Ingo , Deuse Tobias , Kluge Stefan
Published: March 2013

Invasive aspergillosis, especially neuroaspergillosis, predominantly affects immunocompromised patients such as transplant recipients. Early diagnosis and subsequent early initiation of therapy may improve final outcome. In cerebral aspergillosis, samples for culture or histopathology, the diagnostic reference standard, are often impossible to obtain without risk. Because of these limitations, serological, nucleic acid amplification tests such as polymerase chain reaction or enzyme immunoassay from cerebrospinal fluid appear advantageous for early diagnosis and probably also for therapy monitoring. We report on the successful detection and treatment monitoring by serial testing of galactomannan in cerebrospinal fluid in a patient with neuroaspergillosis after heart transplant.
Survey of Transplant-Related Pharmacy Services at Large Comprehensive Transplant Centers in the United States
Authors: Staino Carmelina , Lewin John J. , Nesbit Todd W. , Sullivan Brigitte , Ensor Christopher R.
Published: March 2013

Context

United Network for Organ Sharing (UNOS) 2011 bylaws and Centers for Medicare and Medicaid Services (CMS) regulations require a transplant pharmacist to be an active participant in the care of transplant patients. Transplant centers must be members in good standing with UNOS in order to perform transplants and must be certified by CMS to participate with Medicare.

Objective

To identify characteristics of transplant-related pharmacy services at comprehensive transplant centers.

Design

Survey regarding number of full-time equivalent (FTE) transplant pharmacists relative to number of annual transplants, transplant pharmacy model, roles in inpatient and clinic environments, training and specialization, funding sources, and expansion plans.

Participants

Surveys were received from 14 (74%) of 19 identified centers that performed 200 to 400 kidney, liver, pancreas, simultaneous kidney/pancreas, heart, and lung transplants in 2010, representing 55 transplant pharmacists. Results—A mean of 325 transplants were performed in 2010 at the surveyed centers. The mean number of pharmacist FTEs was 4.25, which yielded a transplant-to-pharmacist ratio of 76.5. Nine centers (64%) practiced in a pharmacy specialist-only model, 12 (86%) practiced in a service-based fashion, and 10 (71%) saw patients in clinic. Fifty-four pharmacists (98%) had obtained a PharmD degree, 45 (82%) had completed 1 postgraduate year, and 28 (51%) had completed 2 postgraduate years of training. Nine centers (64%) funded FTEs solely through the pharmacy department. Ten centers (71%) plan to expand transplant pharmacist staff by a mean of 1.4 FTEs.

Conclusions

Large comprehensive transplant centers use multiple transplant pharmacists to perform patient care in the inpatient and outpatient environments. Most centers plan to expand FTEs. Further characterization of transplant pharmacists appears warranted.
Consent to Organ Donation: A Review
Authors: Siminoff Laura A. , Agyemang Amma A. , Traino Heather M.
Published: March 2013

Successful transplant medicine hinges on consent to deceased organ donation. Yet rates of consent remain suboptimal. To increase the availability of transplantable organs, several policy strategies along with a rich body of evidence aimed at identifying best practices for obtaining consent have accumulated. This review describes past and current policies and practices, presents evidence illustrating the impact of these policies and practices on consent, and summarizes future directions and recommendations for the field. Key findings include evidence that although past policies such as required request have been unsuccessful, the recent policy, first-person authorization, shows promise. Additionally, practices such as decoupling and detailed discussions of brain death are unwarranted. On the other hand, the Organ Donation Breakthrough Collaboration was successful. We also underscore the impact of alternative procedures such as donation after cardiac death. Last, effective communication that is delivered by trained, caring requesters at the appropriate time, in a supportive environment, and allows sufficient time for families to make an informed decision, optimizes the request process. Organ procurement organizations' adoption of such request practices, implementation of evidence-based policies regarding donation after cardiac death, and further investigations of the medical basis for dual brain death examinations are recommended.
Le rapport de recherche : un méga-outil pour « nourrir » l’enseignement des sciences
Authors: Rivard Léonard P. , Martin Luc N. , Saurette Fernand
Published: March 2013

Le rapport de recherche est le genre de texte dominant de la communauté scientifique. Cependant, tous les enseignants de sciences ne connaissent pas nécessairement ses particularités. Le but de cet article est d’aider ces derniers en examinant les différentes parties qui constituent les rapports de recherche publiés dans les revues savantes. Au cours de l’analyse, nous commenterons les idées que l’auteur développe dans chaque partie (le fond) ainsi que les éléments linguistiques auxquels il a recours (la forme). Nous émettrons finalement des recommandations à l’intention des enseignants qui aimeraient transposer les idées présentées lorsqu’ils exploitent le rapport de laboratoire pour développer davantage l’écrit chez leurs élèves.
Tenure-Track Science Faculty and the ‘Open Access Citation Effect’
Authors: Doty R Christopher
Published: March 2013

INTRODUCTION The observation that open access (OA) articles receive more citations than subscription-based articles is known as the OA citation effect (OACE). Implicit in many OACE studies is the belief that authors are heavily invested in the number of citations their articles receive. This study seeks to determine what influence the OACE has on the decision-making process of tenure-track science faculty when they consider where to submit a manuscript for publication. METHODS Fifteen tenure-track faculty members in the Departments of Biology and Chemistry at the University of North Carolina at Chapel Hill participated in semi-structured interviews employing a variation of the critical incident tecnique. RESULTS Seven of the fifteen faculty members said they would consider making a future article freely-available based on the OACE. Due to dramatically different expectations with respect to the size of the OACE, however, only one of them is likely to seriously consider the OACE when deciding where to submit their next manuscript for publication. DISCUSSION Journal reputation and audience, and the quality of the editorial and review process are the most important factors in deciding where to submit a manuscript for publication. Once a subset of journals has satisfied these criteria, financial and access issues compete with the OACE in making a final decision. CONCLUSION In order to increase the number of OA materials, librarians should continue to emphasize depositing pre- and post-prints in disciplinary and institutional repositories and retaining the author rights prior to publication in order to make it possible to do so.
Multi Variant Surface Mounted Metal–Organic Frameworks
Authors: Liu Bo , Tu Min , Zacher Denise , Fischer Roland A.
Published: March 2013

Hybrid surface mounted metal–organic frameworks (h‐SURMOFs) of multi variant core‐shell (cs) and core–shell–shell (css) structures (SURMOF A‐B and A‐B‐C, A: [Cu2(bdc)2(dabco)]; B: [Cu2(NH2‐bdc)2(dabco)]; C: [Cu2(ndc)2(dabco)], bdc = 1,4‐benzenedicarboxylate; NH2‐bdc = 2‐amino‐1,4‐benzenedicarboxylate; ndc = 1,4‐naphtalenedicarboxylate; dabco = 1,4‐diazabicyclo[2.2.2]octane) with specific crystallographic [001] orientation and incorporated amino groups at a controllable depth within the bulk are deposited via liquid phase epitaxial (LPE) approach on pyridyl‐terminated self‐assembled monolayers (SAM). The location of the (amino) functionality can be precisely controlled through tuning the thickness (number of deposition cycles) of each sub‐multilayer block according to the LPE deposition protocol. The chemo‐selective and location‐specific post deposition (chemical) modification of the amino groups in the cs and css‐type h‐SURMOF samples is achieved. The h‐SURMOFs allow one to probe functional groups at certain location in the volume of hybrid MOF crystallites attached to surfaces as thin film coatings. Multiplex adsorption kinetics of FPI (FPI = 4‐fluorophenyl isothiocyanate) is observed in h‐SURMOFs due to their multi‐variant pore structures in samples of A‐B and A‐B‐C. Conceptually, the stepwise LPE growth method enables fabrication of hybrid SURMOFs and incorporation of multi‐variant functionalities into one homogeneous thin film material, providing precisely tunable pore environment for selective adsorption, separation, etc.
Racemization‐Free Chemoenzymatic Peptide Synthesis Enabled by the Ruthenium‐Catalyzed Synthesis of Peptide Enol Esters via Alkyne‐Addition and Subsequent Conversion Using Alcalase‐Cross‐Linked Enzyme Aggregates
Authors: Schröder Hilmar , Strohmeier Gernot A. , Leypold Mario , Nuijens Timo , Quaedflieg Peter J. L. M. , Breinbauer Rolf
Published: March 2013

The C‐terminal activation of peptides as prerequisite for the formation or ligation of peptide fragments is often associated with the problem of epimerization. We report that ruthenium‐catalyzed alkyne addition with (+)‐2,3‐O‐isopropylidene‐2,3‐dihydroxy‐1,4‐bis(diphenylphosphino)butane as ligand allows the racemization‐free synthesis of peptide enol esters tolerating a wide range of functional groups. The transformation can be performed in a variety of different solvents addressing the solubility issues imposed by peptides with varying amino acid side chain patterns. We show that peptide enol esters with an amide motif in the enol moiety are excellent acyl donors for the peptide condensation with other peptide fragments in organic solvents using serine endopeptidase subtilisin A as catalyst. The reported combination of transition metal catalysis with enzymatic peptide ligations adds an important tool for the racemization‐free synthesis and ligation of peptides which is compatible even with unprotected amino acid side chains.
An Asymmetric Organocatalytic Quadruple Cascade Initiated by a Friedel–Crafts‐Type Reaction with Electron‐Rich Arenes
Authors: Erdmann Nico , Philipps Arne R. , Atodiresei Iuliana , Enders Dieter
Published: March 2013

An organocatalytic quadruple domino reaction initiated by a Friedel–Crafts‐type reaction of electron‐rich arenes is described. The procedure involving up to three different Michael acceptors afforded highly functionalized cyclohexenecarbaldehydes bearing an aniline moiety, which are of great pharmaceutical and agricultural interest. This diphenylprolinol trimethylsilyl ether‐catalyzed reaction also generates up to 4 contiguous stereocenters. It could be shown that various functional groups are tolerated and all products were obtained with very good diastereo‐ and excellent enantioselectivity.
Precarious employment, psychosocial working conditions, and health: Cross‐sectional associations in a population‐based sample of working Australians
Authors: Keuskamp Dominic , Ziersch Anna M. , Baum Fran E. , LaMontagne Anthony D.
Published: March 2013

Background

Precarious employment has been associated with poor health, but the potential mechanisms are unclear. We examined the relationships between precarious employment and health, and investigated psychosocial working conditions as potential mediators.

Methods

A cross‐sectional population‐based survey was conducted in South Australia in 2009 (N = 1,016 employed). SF‐12 measures of mental and physical health were modeled using logistic regression in relation to employment arrangement, controlling for socio‐demographics, years in job and psychosocial working conditions.

Results

There was no association between casual full‐time or part‐time employment and poor mental health in multivariate analyses. Conversely, there was a significant association between casual full‐time employment and poor physical health (compared to permanent full‐time workers, OR = 3.14, 95% CI 1.26–7.85). The association with physical health was unaffected by adjustment for psychosocial working conditions.

Conclusions

Casual full‐time employment was strongly associated with poor physical health but not with poor mental health. This association was not mediated by the psychosocial working conditions measured in this study, but may be related to other (unmeasured) working conditions. Am. J. Ind. Med. 56:838–844, 2013. © 2013 Wiley Periodicals, Inc.
A quantitative approach for understanding small‐scale human mesenchymal stem cell culture – implications for large‐scale bioprocess development
Authors: Rafiq Qasim A. , Coopman Karen , Nienow Alvin W. , Hewitt Christopher J.
Published: March 2013

Human mesenchymal stem cell (hMSC) therapies have the potential to revolutionise the healthcare industry and replicate the success of the therapeutic protein industry; however, for this to be achieved there is a need to apply key bioprocessing engineering principles and adopt a quantitative approach for large‐scale reproducible hMSC bioprocess development. Here we provide a quantitative analysis of the changes in concentration of glucose, lactate and ammonium with time during hMSC monolayer culture over 4 passages, under 100% and 20% dissolved oxgen (dO2), where either a 100%, 50% or 0% growth medium exchange was performed after 72h in culture. Yield coefficients, specific growth rates (h‐1) and doubling times (h) were calculated for all cases. The 100% dO2 flasks outperformed the 20% dO2 flasks with respect to cumulative cell number, with the latter consuming more glucose and producing more lactate and ammonium. Furthermore, the 100% and 50% medium exchange conditions resulted in similar cumulative cell numbers, whilst the 0% conditions were significantly lower. Cell immunophenotype and multipotency were not affected by the experimental culture conditions. This study demonstrates the importance of determining optimal culture conditions for hMSC expansion and highlights a potential cost savings from only making a 50% medium exchange, which may prove significant for large‐scale bioprocessing.
Cooperative binding of 2,2′‐bipyridine into polynucleotide poly(A)–poly(U‐) in an alkaline aqueous solution
Authors: Kudrev Andrei G.
Published: March 2013

UV absorption data analysis has been used to evaluate equilibrium constants of the pH‐induced interaction of 2,2′‐Bipy with polyadenylnic‐polyuridylic acid in aqueous solution. The conditional probabilities hard model has been adopted in treatment of concentration diagrams calculated by the soft modelling‐based Multivariate Curve Resolution‐Alternating Least Squares approach. Intrinsic binding constant (lgKg = 1.93), and the cooperativity parameter (ω = 340), were calculated as the best fit. The plot of the experimental binding constant versus 2,2′‐Bipy equilibrium concentration shows two modes of ligand with polymer interactions. The equilibrium hard model correctly reproduced the binding constant variations observed in the experiment. The results indicated that ligand binding in two steps is governed by a cooperative process, that is, the enhancement of deprotonated structure stability. It would appear that proposed calculation approach can be used in future combined hard modelling theoretical and soft modelling experimental works. © 2013 Wiley Periodicals, Inc. Biopolymers 99:621–627, 2013.
Reactions of Copper(II) Chloride in Solution: Facile Formation of Tetranuclear Copper Clusters and Other Complexes That Are Relevant in Catalytic Redox Processes
Authors: Löw Sabine , Becker Jonathan , Würtele Christian , Miska Andreas , Kleeberg Christian , Behrens Ulrich , Walter Olaf , Schindler Siegfried
Published: March 2013

Mixing CuCl2⋅2 H2O with benzylamine in alcoholic solutions led to an extremely colorful chemistry caused by the formation of a large number of different complexes. Many of these different species could be structurally characterized. These include relatively simple compounds such as [Cu(L1)4Cl2] (L1=benzylamine) and (HL1)2[CuCl4]. Most interestingly is the easy formation of two cluster complexes, one based on two cluster units Cu4OCl6(L1)4 connected through one [Cu(L1)2Cl2] complex and one based on a cubane‐type cluster ([Cu4O4](C11H14)4Cl4). Both clusters proved to be highly reactive in a series of oxidation reactions of organic substrates by using air or peroxides as oxidants. Furthermore, it was possible to isolate and structurally characterize ([Cu(L1)Cl]3 and [Cu(benz2mpa)2]CuCl2 (benz2mpa=benzyl‐(2‐benzylimino‐1‐methyl‐propylidene)‐amine), two copper(I) complexes that formed in solution, demonstrating the high redox activity of the cluster systems. In addition, it was possible to solve the molecular structures of the compounds Cu4OCl6(MeOH)4, [Cu(MeOH)2Cl2], [Cu(aniline)2Cl2], and an organic side product (HC13H19NOCl). In fact all determined structures are of a known type but the chemical relation between these compounds could be explained for the first time. The paper describes these different compounds and their chemical equilibria. Some of these complexes seem to be relevant in catalytic oxidation reactions and their reactivity is discussed in more detail.
Noncovalent Tagging Proteins with Paramagnetic Lanthanide Complexes for Protein Study
Authors: Wei Zhen , Yang Yin , Li Qing‐Feng , Huang Feng , Zuo Hui‐Hui , Su Xun‐Cheng
Published: March 2013

The site‐specific labeling of proteins with paramagnetic lanthanides offers unique opportunities for NMR spectroscopic analysis in structural biology. Herein, we report an interesting way of obtaining paramagnetic structural restraints by employing noncovalent interaction between a lanthanide metal complex, [Ln(L)3]n− (L=derivative of dipicolinic acid, DPA), and a protein. These complexes formed by lanthanides and DPA derivatives, which have different substitution patterns on the DPA derivatives, produce diverse thermodynamic and paramagnetic properties when interacting with proteins. The binding affinity of [Ln(L)3]n− with proteins, as well as the determined paramagnetic tensor, are tunable by changing the substituents on the ligands. These noncovalent interactions between [Ln(L)3]n− and proteins offer great opportunities in the tagging of proteins with paramagnetic lanthanides. We expect that this method will be useful for obtaining multiple angles and distance restraints of proteins in structural biology.
ChemInform Abstract: Temperature‐Dependent Structural Studies of Mullite‐Type Bi2Fe4O9.
Authors: Murshed M. Mangir , Nenert Gwilherm , Burianek Manfred , Robben Lars , Muehlberg Manfred , Schneider Hartmut , Fischer Reinhard X. , Gesing Thorsten M.
Published: March 2013

The thermal expansion of the title compound (space group Pbam) is investigated by single crystal neutron diffraction at 298 and 900 K and powder XRD over the range 298—1173 K.
ChemInform Abstract: The New Barium Mercuride BaHg6 and Ternary Indium and Gallium Derivatives.
Authors: Wendorff Marco , Roehr Caroline
Published: March 2013

BaHg6 (I), BaIn1.2Hg4.8 (II), and BaGa0.8Hg5.2 (III) are obtained from melts of the elements in Ta crucibles by slow cooling from 500 to 200 °C.
ChemInform Abstract: Amine Templating Effect Absent in Uranyl Sulfates Synthesized with 1,4‐n‐Butyldiamine.
Authors: Jouffret Laurent J. , Wylie Ernest M. , Burns Peter C.
Published: March 2013

The new compounds (IV) and (V) crystallize in the monoclinic space group P21/n with Z = 4 (single crystal XRD).
ChemInform Abstract: Synthesis, Crystal Structure, and Properties of KSbO3‐Type Bi3Mn1.9Te1.1O11.
Authors: Greenblatt Martha , et al. et al.
Published: March 2013

Single crystals of the title compound are prepared by reaction of a stoichiometric mixture of Bi2O3, MnCO3, and TeO2 in a NaCl/KCl flux (air, open quartz tube, 750 °C, 10 d).
ChemInform Abstract: New Multifunctional Chiral Phosphines and BINOL Derivatives Co‐Catalyzed Enantioselective Aza‐Morita—Baylis—Hillman Reaction of 5,5‐Disubstituted Cyclopent‐2‐enone and N‐Sulfonated Imines.
Authors: Yang Yuan‐Liang , Wei Yin , Shi Min
Published: March 2013

A chiral and strong nucleophilic phosphine amide catalyst combined with a BINOL derivative catalyzes the asymmetric aza‐Morita—Baylis—Hillmann reaction of disubstituted cyclopentenones (I) and (IV) with N‐sulfonated imines (II) and (V) to provide the optically active adducts (III) and (VI) in good to outstanding yields with moderate to good enantioselectivities.
ChemInform Abstract: Camphor‐Derived C1‐Symmetric Chiral Diamine Organocatalysts for Asymmetric Michael Addition of Nitroalkanes to Enones.
Authors: Zhou Yirong , Liu Qiang , Gong Yuefa
Published: March 2013

A small library of novel C1‐symmetric chiral diamines is constructed in moderate to good yields by using three protocols.
ChemInform Abstract: Halofluorination of Alkenes Mediated by 1,1,3,3,3‐Pentafluoropropene‐diethylamine Adduct.
Authors: Walkowiak Justyna , Marciniak Bartosz , Koroniak Henryk
Published: March 2013

The halofluorination reaction most probably proceeds via controlled generation of limited amounts of hydrogen fluoride from the 1,1,3,3,3‐pentafluoropropene‐diethylamine adduct PFPD.
ChemInform Abstract: Ligated Regioselective PdII Catalysis to Access β‐Aryl‐Bearing Aldehydes, Ketones, and β‐Keto Esters.
Authors: Vellakkaran Mari , Andappan Murugaiah M. S. , Kommu Nagaiah
Published: March 2013

The title acid‐free method is based on the coupling of allyl alcohols with arylboronic acids to access dihydrochalcones, dihydrocinnamaldehydes, and β‐arylketones with more tolerance of functionalities than previously reported.
ChemInform Abstract: Rational Design of a Palladium‐Catalyzed Csp—Csp Cross‐Coupling Reaction Inspired by Kinetic Studies.
Authors: Weng Yue , Cheng Ben , He Chuan , Lei Aiwen
Published: March 2013

The highly selective, efficient, simple, and mild method affords a series of synthetically important diyne systems.
ChemInform Abstract: Palladium‐Catalyzed Allylic Fluorination of Cinnamyl Phosphorothioate Esters.
Authors: Lauer Andrew M. , Wu Jimmy
Published: March 2013

The halogenation proceeds with excellent regioselectivity except in the case of substrate (III).
ChemInform Abstract: Palladium(II)‐Catalyzed Regioselective ortho Arylation of sp2 C—H Bonds of N‐Aryl‐2‐amino Pyridine Derivatives.
Authors: Koley Moumita , Dastbaravardeh Navid , Schnuerch Michael , Mihovilovic Marko D.
Published: March 2013

The convenient method uses pyridine as directing group.
ChemInform Abstract: Straightforward Synthesis of Aromatic Imines from Alcohols and Amines or Nitroarenes Using an Impregnated Copper Catalyst.
Authors: Perez Juana M. , Cano Rafael , Yus Miguel , Ramon Diego J.
Published: March 2013

The present magnetically removable catalyst system consisting of impregnated copper on magnetite is used for the synthesis of imines starting from alcohols and aryl amines or nitroarenes.
ChemInform Abstract: A Facile and Efficient Synthesis of 2,2,2‐Trifluoroethyl 2‐[(E)‐N‐Phenylcinnamamido]‐2‐phenylacetates in Trifluoroethanol via Sequential Ugi Four‐Component Reaction/Esterification.
Authors: Balalaie Saeed , Motaghedi Hassan , Tahmassebi Daryoush , Bararjanian Morteza , Bijanzadeh Hamid Reza
Published: March 2013

The primary Ugi adducts (V) are esterified by the solvent (VI) under conditions B) to afford the highly functionalized scaffolds of type (VII).
ChemInform Abstract: Synthesis of α‐Aminonitriles Using Silica‐Bonded N‐Propylpiperazine Sulfamic Acid as a Recyclable Catalyst.
Authors: Rahi Tahere , Baghernejad Mojtaba , Niknam Khodabakhsh
Published: March 2013

A simple protocol for the three‐component condensation of aldehydes, amines, and trimethylsilyl cyanide to yield α‐aminonitriles (IV) (12 examples) is developed using a heterogeneous supported sulfamic acid as the catalyst.
ChemInform Abstract: Squaramide‐Catalyzed Enantio‐ and Diastereoselective sulfa‐Michael Addition of Thioacetic Acid to α,β‐Disubstituted Nitroalkenes.
Authors: Yang Wen , Du Da‐Ming
Published: March 2013

The title reaction affords various biologically important sulfur compounds.
ChemInform Abstract: AgI‐Catalyzed Cascade Strategy: Regioselective Access to Diversely Substituted Fused Benzimidazo[2,1‐a]isoquinolines, Naphthyridines, Thienopyridines and Quinoxalines in Water.
Authors: Rustagi Vineeta , Tiwari Rakesh , Verma Akhilesh Kumar
Published: March 2013

Title compounds are synthesized in one step by the present eco‐friendly reaction of o‐alkynyl aldehydes and amines in water using AgNO3 as catalyst.
ChemInform Abstract: A Non‐Heme Iron(III) Complex with Porphyrin‐Like Properties that Catalyzes Asymmetric Epoxidation.
Authors: Niwa Takashi , Nakada Masahisa
Published: March 2013

The Fe complex is a good surrogate for traditional porphyrins.
ChemInform Abstract: A Visible‐Light‐Mediated Oxidative C—N Bond Formation/Aromatization Cascade: Photocatalytic Preparation of N‐Arylindoles.
Authors: Maity Soumitra , Zheng Nan
Published: March 2013

The conditions are compatible with the presence of a variety of functional groups.
ChemInform Abstract: Phosphine‐Catalyzed Domino Reaction: An Efficient Method for the Synthesis of Highly Functionalized Spirooxazolines.
Authors: Yang Lihua , Xie Peizhong , Li Erqing , Li Xin , Huang You , Chen Ruyu
Published: March 2013

A new class of spirocyclic oxindole derivatives is obtained in good to high yields and stereoselectivity by a novel phosphine‐catalyzed intermolecular [3 + 2]cycloaddition of isatins and ynones.
ChemInform Abstract: A Diversity‐Oriented Approach to Spiroindolines: Post‐Ugi Gold‐Catalyzed Diastereoselective Domino Cyclization.
Authors: Modha Sachin G. , Kumar Amit , Vachhani Dipak D. , Jacobs Jeroen , Sharma Sunil K. , Parmar Virinder S. , Van Meervelt Luc , Van der Eycken Erik V.
Published: March 2013

A mild and efficient synthesis of the title compounds is developed from readily available starting materials.
ChemInform Abstract: Construction of Naphtho‐Fused Oxindoles via the Aryne Diels—Alder Reaction with Methyleneindolinones.
Authors: Li Jian , Wang Ning , Li Chunju , Jia Xueshun
Published: March 2013

The process renders possible the access to a broad spectrum of highly functionalized N‐heterocyclic systems incorporating the indole scaffold.
ChemInform Abstract: A Novel Synthesis of Thioglycolurils by Ring Contraction of 5,7‐Dialkyl‐3‐thioxoperhydroimidazo[4,5‐e]‐1,2,4‐triazin‐6‐ones.
Authors: Gazieva Galina A. , Poluboyarov Pavel A. , Popov Leonid D. , Kolotyrkina Natalya G. , Kravchenko Angelina N. , Makhova Nina N.
Published: March 2013

Triazinethiones of type (I) are found to undergo a novel type of ring contraction by acid catalyzed reaction with aromatic aldehydes to give thioglycolurils (III) in moderate yields.
ChemInform Abstract: Synthesis of Oxazolidinones, Dioxazolidinone and Polyoxazolidinone (a New Polyurethane) via a Multi Component‐Coupling of Aldehyde, Diamine Dihydrochloride, Terminal Alkyne and CO2.
Authors: Teffahi Djamila , Hocine Smain , Li Chao‐Jun
Published: March 2013

Optimized conditions A) render possible the preparation of various oxazolidinone structures.
ChemInform Abstract: Palladium‐Catalyzed, Pyrrolidine‐Mediated Arylmethylation of Ketones and Aldehydes with Coumarinyl(methyl) Acetates.
Authors: Cattopadhyay Kalicharan , Recio Antonio III , Tunge Jon A.
Published: March 2013

The mild α‐benzylation of enamines generated from aldehydes and ketones is reported.
ChemInform Abstract: Mild Metal‐Free Tandem α‐Alkylation/Cyclization of N‐Benzyl Carbamates with Simple Olefins.
Authors: Richter Heinrich , Froehlich Roland , Daniliuc Constantin‐Gabriel , Garcia Mancheno Olga
Published: March 2013

The first examples for metal‐free α‐alkylation of N‐benzyl carbamates are presented.
ChemInform Abstract: Kinetic versus Thermodynamic Stereoselectivity in the Hydrostannylation of Propargylic Alcohol Derivatives Using AIBN and Et3B as Promotors.
Authors: Oderinde Martins S. , Hunter Howard N. , Organ Michael G.
Published: March 2013

While BEt3/air furnishes the kinetically controlled Z‐isomer in the title reaction, isomerization is observed in the analog AIBN‐mediated reactions.
ChemInform Abstract: Lignans and Triterpenes from the Root of Pseuderanthemum carruthersii var. atropurpureum.
Authors: Vo Thi Nga , Nguyen Phi Linh , Tuong Lam Truong , Pratt Lawrence Michael , Vo Phung Nguyen , Nguyen Kim Phi Phung , Nguyen Ngoc Suong
Published: March 2013

Two new lignans, pseuderesinol (I) and pseuderanoside (II), and a new triterpene, pseuderanic acid (III), are isolated together with ten known compounds.
ChemInform Abstract: Reactions Associated with Arene Replacement in Bis‐(arene) Iron Complexes
Authors: Stibr Bohumil
Published: March 2013

Review: 37 refs.
ChemInform Abstract: Carboxylates as Sources of Carbon Nucleophiles and Electrophiles: Comparison of Decarboxylative and Decarbonylative Pathways
Authors: Dzik Wojciech , Lange Paul P. , Goossen Lukas J.
Published: March 2013

Review: 57 refs.
ChemInform Abstract: Organic Fluorine as a Polypeptide Building Element: In vivo Expression of Fluorinated Peptides, Proteins and Proteomes
Authors: Merkel L. , Budisa N.
Published: March 2013

Review: 171 refs.
ChemInform Abstract: Iminium Catalysis with Primary Amines
Authors: Liu Y. , Melchiorre P.
Published: March 2013

Review: 83 refs.
ChemInform Abstract: SOMO and Radical Chemistry in Organocatalysis
Authors: MacMillan D. W. C. , Beeson T. D.
Published: March 2013

Review: 58 refs.
ChemInform Abstract: Enamine Catalysis of α‐Functionalizations and Alkylations
Authors: Mukherjee S.
Published: March 2013

Review: 81 refs.
ChemInform Abstract: Enamine Catalysis of Intermolecular Aldol Reactions
Authors: Yliniemela‐Sipari S. M. , Piisola A. , Pihko P. M.
Published: March 2013

Review: 169 refs.
ChemInform Abstract: Palladium‐Catalyzed Dual C—H or N—H Functionalization of Unfunctionalized Indole Derivatives with Alkenes and Arenes
Authors: Broggini Gianluigi , Beccalli Egle M. , Fasana Andrea , Gazzola Silvia
Published: March 2013

Review: 86 refs.
ChemInform Abstract: Synthesis of Cyclopropane Compounds. Bicyclo[1.1.0]butanes, Spiropentanes, and Bicyclopropanes
Authors: Ramazanov I. R. , Yaroslavova A. V. , Dzhemilev U. M.
Published: March 2013

Review: 308 refs.
ChemInform Abstract: Microwave‐Mediated Synthesis
Authors: Das Rina , Mehta Dinesh , Bhardawaj Harsh
Published: March 2013

Review: 17 refs.
ChemInform Abstract: Hydra, a Fruitful Model System for 270 Years
Authors: Galliot Brigitte
Published: March 2013

Review: 219 refs.
ChemInform Abstract: Diterpenes from European Euphorbia Species Serving as Prototypes for Natural‐Product‐Based Drug Discovery
Authors: Vasas Andrea , Redei Dora , Csupor Dezsoe , Molnar Joseph , Hohmann Judit
Published: March 2013

Review: isolation, characterization, screening methods; 141 refs.
ChemInform Abstract: Transition Metal Complexes in Supported Liquid Phase and Supercritical Fluids — A Beneficial Combination for Selective Continuous‐flow Catalysis with Integrated Product Separation
Authors: Hintermair Ulrich , Chinnusamy Tamilselvi , Leitner Walter
Published: March 2013

Review: 158 refs.
ChemInform Abstract: Solid‐State NMR of the Bacterial Cell Wall
Authors: Bougault Catherine , Hediger Sabine , Simorre Jean‐Pierre
Published: March 2013

Review: 79 refs.
Study of the Transient Reactive Pd(IV) Intermediate in the Pd(OAc)2‐Catalyzed Oxidative Coupling Reaction System by Electrospray Ionization Tandem Mass Spectrometry
Authors: Zhu Wei , Wang Haoyang , Peng Haihui , Liu Guosheng , Guo Yinlong
Published: March 2013

Pd‐catalyzed oxidative coupling reaction was of great importance in the aromatic CH activation and the formation of new CO and CC bonds. Sanford has pioneered practical, directed CH activation reactions employing Pd(OAc)2 as catalyst since 2004. However, until now, the speculated reactive Pd(IV) transient intermediates in these reactions have not been isolated or directly detected from reaction solution. Electrospray ionization tandem mass spectrometry (ESI‐MS/MS) was used to intercept and characterize the reactive Pd(IV) transient intermediates in the solutions of Pd(OAc)2‐catalyzed oxidative coupling reactions. In this study, the Pd(IV) transient intermediates were detected from the solution of Pd(OAc)2‐catalyzed oxidative coupling reactions by ESI‐MS and the MS/MS of the intercepted Pd(IV) transient intermediate in reaction system was the same with the synthesized authentic Pd(IV) complex. Our ESI‐MS(/MS) studies confirmed the presence of Pd(IV) reaction transient intermediates. Most interestingly, the MS/MS of Pd(IV) transient intermediates showed the reductive elimination reactivity to Pd(II) complexes with new CO bond formation into product in gas phase, which was consistent with the proposed reactivity of the Pd(IV) transient intermediates in solution.
Effects of Time‐Since‐Fire on Vegetation Composition and Structures in Semi‐Arid Perennial Grassland on the Loess Plateau, China
Authors: Wu Gao‐Lin , Zhao Ling‐Ping , Wang Dong , Shi Zhi‐Hua
Published: March 2013

Although there is an increased understanding of fire's role in maintaining grassland ecosystems, few studies on vegetation develops after a fire disturbance has been reported in arid perennial grasslands on the Loess Plateau. To understand how vegetation recovers after a fire disturbance, we studied three grassland sites with different times since last fire in arid steppe on the Loess Plateau, China. Results showed that 2 years after a fire, total cover, species abundance, and diversity rapidly recovered and increased to higher than unburned grasslands. Rapid recovery after a fire disturbance was mainly attributed to the removal of litter which provided better microhabitats for lower dominance species and the vegetative regeneration of perennial species following fire. Fire has little effects on the composition of grassland species in the long run if the grasslands were dominated by perennial species because asexual recruitment plays an important role in the vegetation recovery after fire. The accumulated litter seems not a major reason explaining why fire does not significantly alter vegetation composition in studied grasslands. Low frequency fire is helpful to the renewal of grassland. Our results suggested that opportune fire is an effective regulator of plant composition and maintenance in arid grassland.
Morphology of 9p21 homozygous deletion‐positive pleural mesothelioma cells analyzed using fluorescence in situ hybridization and virtual microscope system in effusion cytology
Authors: Matsumoto Shinji , Nabeshima Kazuki , Kamei Toshiaki , Hiroshima Kenzo , Kawahara Kunimitsu , Hata Sakae , Marukawa Katsuji , Matsuno Yoshihiro , Taguchi Kenichi , Tsujimura Tohru
Published: March 2013

BACKGROUND

In malignant pleural mesothelioma (MPM), most patients first present with pleural effusion; thus, cytologic analysis is the primary diagnostic approach. However, the cytologic distinction between MPM and reactive mesothelial cells (RMCs) in effusions can be extremely difficult due to the lack of both well‐established immunocytochemical markers and definite cytological criteria for MPM. Moreover, the existence of both MPM cells and RMCs in effusions from the same patient makes the differentiation even more challenging. Homozygous deletion of the 9p21 locus, the site of the cyclin‐dependent kinase inhibitor 2A/p16 (CDKN2A/p16) gene, frequently occurs in MPM but has never been reported in RMCs. The aim of this study was to define the cytomorphological characteristics of MPM cells, identified by the presence of 9p21 homozygous deletion by fluorescence in situ hybridization (FISH).

METHODS

For this purpose, cells on smear preparations were recorded using a virtual microscope system and were subjected to FISH analysis. Thereafter, 9p21 homozygous deletion‐positive cells were identified in the recorded virtual slides, followed by analysis of their morphological characteristics.

RESULTS

Mesothelioma cells positive for the 9p21 homozygous deletion exhibited significantly more frequent cell‐in‐cell engulfment, multinucleation (more than 2 nuclei), and larger multicellular clusters composed of more than 10 cells than did 9p21 deletion‐negative RMCs. Possible cutoff values are also proposed for these morphological markers to differentiate MPM cells from RMCs.

CONCLUSIONS

These morphological differences and cutoff values are useful for cytological differentiation of mesothelioma cells from RMCs. In addition, the novel technique of a combination of virtual microscopy and FISH is introduced for tumor morphological analysis. Cancer (Cancer Cytopathol) 2013;121:415–22. © 2013 American Cancer Society.