bluuebunny/crossref_metadata_2025 huggingface dataset:
Differential diagnosis of ascites: etiologies, ascitic fluid analysis, diagnostic algorithm
Authors: Du Li , Wei Ning , Maiwall Rakhi , Song Yuhu
Published: December 2023

Ascites is the pathological accumulation of fluid within the peritoneal cavity. It often occurs as results of liver cirrhosis, malignant neoplasia, tuberculous infection, cardiac insufficiency, renal diseases, etc. Determining the etiology is an essential step in the management of patients with new-onset ascites. Abdominal paracentesis with appropriate ascitic fluid analysis is probably the most cost-effective method of determining the cause of ascites. We performed a literature search of PubMed and identified articles published in the field of ascites, to evaluate diagnostic values of various parameters in defining the etiologies of ascites and then provides diagnostic algorithm for patients with new-onset ascites. In patients with ascites, the constituent ratio of underlying etiology varies between developed and developing countries. It is a challenge to define the etiologies of ascites in developing countries. Routine ascitic fluid analysis should include the serum ascites albumin gradient (SAAG), total protein concentration, cell count and differential. Optional ascitic fluid analysis includes cholesterol, fluid culture, cytology, tumor markers, lactate dehydrogenase, adenosine deaminase (ADA), triglyceride, amylase, glucose, brain natriuretic peptide (BNP), etc. Our review evaluated diagnostic values of the above parameters in defining the etiologies of ascites. Diagnostic algorithm established in this review would provide a practical and convenient diagnostic strategy for clinicians in diagnosing patients with new-onset ascites.
An Inter-Laboratory Comparison for the Urinary Acrolein Biomarker 3-Hydroxypropyl-Mercapturic Acid (3-HPMA)
Authors: Scherer Gerhard , Heller Wolf-Dieter , McEwan Michael , Göen Thomas , Joza Peter , Liu Nan , Newland Kirk , Schettgen Thomas , Wang Sheng , Sohn Hyung-Ok , Troude Valerie , Yuki Dai , Zheng Saijing , Zhou Guojun
Published: December 2023

An inter-laboratory comparison study on the acrolein biomarker of exposure 3-hydroxypropyl-mercapturic acid (3-HPMA) with 12 laboratories from 7 globally distributed countries was performed. The laboratories received coded triplicates of 4 spiked and lyophilized urine samples (LU, 12 samples) as well as 5 authentic urine pool samples (PU, 15 samples) covering the 3-HPMA concentration range from background (non-smoking) to heavy smoking levels for analysis by using their own (in-house) analytical method. All laboratories applied liquid chromatography with tandem mass spectrometry (LC-MS/MS), with most of them (10 of 12) using solid phase extraction (SPE) as sample work-up procedure. The intra-laboratory variation (indicating repeatability) was determined by calculating the standard deviation (sr) and the coefficient of variation (CVr) of the triplicates, whereas the inter-laboratory variation (indicating reproducibility) was determined by calculating the standard deviation between laboratories (sR) and the corresponding coefficient of variation (CVR). After removal of outlier samples or laboratories, the mean CVr values for LU and PU test samples ranged from 2.1–3.6% (mean: 2.8%) and 2.4–3.7% (mean: 3.3%), respectively, indicating good repeatability for the determination of 3-HPMA in both sample types. CVR for LU and PU test samples ranged from 9.1–31.9% (mean: 18.8%) and 13.9–27.0% (mean: 18.5%), respectively, indicating limited reproducibility in 3-HPMA analysis for both sample types. Re-calculation of the PU results by applying an embedded calibration (EC), derived from the reported peak areas for the LU test samples, somewhat improved the CVR values (range: 9.6–28.8%, mean: 16.7%).

It is concluded that the intra-laboratory variation (repeatability) in the determination of 3-HPMA in urine is in general acceptable in the participating laboratories, while the inter-laboratory variability requires further improvement. The relatively small reduction in the inter-laboratory variability (sR and CVR) by applying an EC suggests that other methodological factors than the standard reference material for 3-HPMA have to be addressed to achieve further improvement in reproducibility.
Passenger flow forecast of tourist attraction based on MACBL in LBS big data environment
Authors: Tang Qili , Yang Li , Pan Li
Published: December 2023

The existing scenic spot passenger flow prediction models have poor prediction accuracy and inadequate feature extraction ability. To address these issues, a multi-attentional convolutional bidirectional long short-term memory (MACBL)-based method for predicting tourist flow in tourist scenic locations in a location-based services big data environment is proposed in this study. First, a convolutional neural network is employed to identify local features and reduce the dimension of the input data. Then, a bidirectional long short-term memory network is utilized to extract time-series information. Second, the multi-head attention mechanism is employed to parallelize the input data and assign weights to the feature data, which deepens the extraction of important feature information. Next, the dropout layer is used to avoid the overfitting of the model. Finally, three layers of the above network are stacked to form a deep conformity network and output the passenger flow prediction sequence. In contrast to the state-of-the-art models, the MACBL model has enhanced the root mean square error index by at least 2.049, 2.926, and 1.338 for prediction steps of 24, 32, and 60 h, respectively. Moreover, it has also enhanced the mean absolute error index by at least 1.352, 1.489, and 0.938, and the mean absolute percentage error index by at least 0.0447, 0.0345, and 0.0379% for the same prediction steps. The experimental results indicate that the MACBL is better than the existing models in evaluating indexes of different granularities, and it is effective in enhancing the forecasting precision of tourist attractions.
Treatment of central nervous system relapse in PLZF::RARA-positive acute promyelocytic leukemia by venetoclax combined with arubicin, cytarabine and intrathecal therapy: a case report
Authors: Zhou Zhonghao , Zhu Feng , Wang Hui , Lu Fengyan , Xue Hongyi
Published: December 2023

Objectives

Patients suffering from refractory acute promyelocytic leukemia with central nervous system relapse often have a poor prognosis. Among these patients, those with PLZF::RARA rearrangement exhibit poor responses to all-trans retinoic acid and conventional chemotherapy. Venetoclax, a selective inhibitor of B-cell lymphoma-2, can cross the blood–brain barrier and has been widely applied to acute myeloid leukemia therapy recently.

Case presentation

A case of central nervous system relapse in a patient with acute promyelocytic leukemia harboring PLZF::RARA rearrangement was successfully treated with anthracycline cytotoxic chemotherapy and cytarabine in combination with venetoclax, resulting in complete remission. Liquid chromatography-tandem mass spectrometry revealed that the concentration of venetoclax in the cerebrospinal fluid (CSF) was approximately 1/1,000 of that in plasma. Following the first treatment course, the patient’s bone marrow sample tested negative for PLZF::RARA. After the third treatment course, abnormal promyelocytic leukemia cells in the CSF were not detected using flow cytometry, and the PLZF::RARA test in the CSF remained negative.

Conclusions

This case report highlights a new approach for the treatment of central nervous system relapse in patients with PLZF::RARA-positive acute promyelocytic leukemia.
Value-Based Search Efficiency Is Encoded in the Substantia Nigra Reticulata Firing Rate, Spiking Irregularity and Local Field Potential
Authors: Narmashiri Abdolvahed , Abbaszadeh Mojtaba , Nadian Mohammad Hossein , Ghazizadeh Ali
Published: December 2023

Recent results show that valuable objects can pop out in visual search, yet its neural mechanisms remain unexplored. Given the role of substantia nigra reticulata (SNr) in object value memory and control of gaze, we recorded its single-unit activity while male macaque monkeys engaged in efficient or inefficient search for a valuable target object among low-value objects. The results showed that efficient search was concurrent with stronger inhibition and higher spiking irregularity in the target-present (TP) compared with the target-absent (TA) trials in SNr. Importantly, the firing rate differentiation of TP and TA trials happened within ∼100 ms of display onset, and its magnitude was significantly correlated with the search times and slopes (search efficiency). Time–frequency analyses of local field potential (LFP) after display onset revealed significant modulations of the gamma band power with search efficiency. The greater reduction of SNr firing in TP trials in efficient search can create a stronger disinhibition of downstream superior colliculus, which in turn can facilitate saccade to obtain valuable targets in competitive environments.
Preisstrategie und Inflation
Authors: Radic Dubravko
Published: December 2023

Nach Jahrzehnten niedriger Inflation müssen sich Unternehmen zunehmend Gedanken machen, wie sie ihre Preisstrategie auf hohe Inflationsraten anpassen. In diesem Artikel diskutieren wir theoretische Überlegungen aus einer betriebswirtschaftlichen Perspektive, wie man dynamisch optimale Preise setzt, wie man im Vorfeld mögliche Auswirkungen auf den Gewinn abschätzt und wie man schließlich unvermeidliche Preisanpassungen durchführen und Risiken einer hohen Inflation minimieren kann.
Staatsversagen als Folge von Marktversagen am Markt für Politik
Authors: Eichenberger Reiner , Stadelmann David
Published: December 2023

Staatsversagen kann als Versagen des Marktes für Politik verstanden werden. Wie auf gewöhnlichen Märkten spielen auf dem Markt für Politik Externalitäten, Monopolmacht und asymmetrische Information eine zentrale Rolle. Wir zeigen, wie die systematische Anwendung der ökonomischen Theorie des Marktversagens neue Erkenntnisse über die zugrunde liegenden Ursachen für Politikversagen liefern kann. Dabei eröffnet sich der gesamte ökonomische Werkzeugkasten, um das Funktionieren politischer Märkte und Institutionen zu verstehen und vor allem zu verbessern.
Huellas de la doctrina krausista en Ensayos Literarios de Carmen de Burgos: el progreso moral y la educación de la mujer
Authors: Niu Mengxue , Nogueroles Jové Marta
Published: December 2023

Carmen de Burgos fue una figura activa en la primera ola del feminismo en España a finales del siglo XIX y principios del XX. En el presente artículo, deseamos explorar la estrecha relación entre su pensamiento femenina y el krausismo, analizando las similitudes con el krausismo plasmadas en su obra temprana Ensayos literarios en la defensa de las reformas educativas, el respeto al talento de la mujer y el énfasis en la higiene y la salud. Concluiremos que su pensamiento feminista no surgió de forma casual y aislada, sino que fue influenciado significativamente por el krausismo.
Signos naturales y signos artificiales
Authors: Fernández Agis Domingo
Published: December 2023

En este trabajo, partiendo de las valiosas aportaciones de María Zambrano, pretendo poner en evidencia que indagar sobre las características de los procesos que subyacen a la emergencia de signos, ya sea a través de la actividad humana esencial o en el complejo curso de desarrollo de los procesos naturales, es algo de vital importancia para la supervivencia humana y animal. Por lo que a nosotros respecta, tal conocimiento es imprescindible para lograr el pleno respeto a la naturaleza y abordar de forma justa y consecuente la apuesta por el futuro de la humanidad.
Mujeres/Cine: Bolivia 1960-2021
Authors: Molina Ergueta Mary Carmen , Zapata Pinto Luis Sergio
Published: December 2023

La investigación colectiva “Cine/Mujeres: Bolivia 1960-2020” trabajó cuatro espacios en el campo cultural cinematográfico-audiovisual en Bolivia. 1) Cineclubismo y cinefilia 60/80; 2) Ukamau (Grupo y Productora Ldta.), colectivos de producción y realizadorxs vinculadxs; 3) Video boliviano (foco en la ciudad de La Paz); y 4) Fin de siglo XX y dos décadas del XXI. la misma opto por una estrategia de difusión de resultados y hallazgos novedosa en el medio boliviano pues realizo una exposición museográfica, publicación de libros, conversatorios y un ciclo de películas dirijas por mujeres bolivianas. La investigación pretende aportar en la construcción de nuevos abordajes sobre la historia cultural y los estudios cinematográficos y audiovisuales en Bolivia.
Retratos a infantes hechos por Daniel Pajuelo en TAFOS El Agustino (1986-1988)
Authors: Leiva Vizconde Juan Carlos Manuel
Published: December 2023

Daniel Pajuelo participó del primer Taller de Fotografía Social (TAFOS) en El Agustino a cargo de Thomas Müller y Servicios Educativos El Agustino (SEA). La muestra en análisis consiste en dos fotografías del archivo TAFOS-PUCP, que exploran la condición de los infantes del distrito entre 1986 y 1988. Mediante el análisis correspondiente, busco responder cómo son representados los niños de El Agustino en las fotografías de Daniel Pajuelo. Son enfatizados con texturas suaves y contrastan con los materiales de las zonas urbanas del distrito.
El enfoque sistémico de Bunge: un acercamiento epistemológico al análisis de la educación
Authors: Ramos Ramos Cristian Yosimar
Published: December 2023

El presente trabajo tiene como objetivo examinar el aporte fundamental de Bunge a la teoría sistémica y proponer una ampliación teórica utilizando la teoría de la acción racional de Elster e incorporando básicamente su explicación mixta (causal-intencional) o interaccionista. La respuesta será una síntesis teórica que nos permitirá explicar las complejas interacciones, siempre que toda acción racional funcione dentro de un sistema.
The traits of mathematics teaching of XII formers
Authors: Cibulskaitė Nijplė
Published: December 2023

The research deals with the scientific problem: what possibilities exist to find the methods to humanize teaching mathematics of XII formers. The aims of this research was to ascertain the traits of mathematics teaching of XII formers.The following peculiarities were defined:– teachers applied such methods as self-control and control in pairs, emphasize of historical elements, independent work and should be recommended to pay more attention to organizing the work of students in groups and with computers, to projects making;– the largest number of students are satisfy of their relations whith mathematics teachers.
Inverse method for modal logic S4
Authors: Birštunas Adomas , Norgėla Stanislovas
Published: December 2023

There is not abstract.
Linear discriminant analysis of interclass correlated spatio-temporal data
Authors: Šaltytė-Benth Jūratė , Dučinskas Kęstutis
Published: December 2023

There is not abstract.
On the spectrum of a stationary problem with nonlocal integral type boundary condition
Authors: Pečiulytė Sigita , Štikonienė Olga , Štikonas Artūras
Published: December 2023

We investigated a eigenvalue problem for simple second order ordinary differential equation with one inte­gral type nonlocal boundary condition. The eigenvalues and eigenfunctions of such problem are depending on few parameters in the nonlocal boundary conditions. For some values of those parameters all eigen­values are positive. We find conditions when there is one zero or one negative eigenvalue. We investigate similar discrete problem too.
Žinių valdymo sistemos taikymas distanciniame mokyme
Authors: Belevičiūtė Inga , Kulvietis Genadijus
Published: December 2023

Society is entering an era the future essentially will be determined by people's ability to wisely use knowledge. This paper presents how knowledge management can be used in distance education.
Development of computer glossary
Authors: Dagienė Valentina , Grigas Gintautas
Published: December 2023

The structure and development of hypertext computer dictionary are discussed. The glossary includes in­formation technology terms as well as words and phrases which appears on the sceen of computer display. The glossary is published in the Internet. Descriptions of the words are comprehensive, illustrated, ani­mation is used in some cases. The users are expected to be localizers of computer software and computer users.
Universality of Dirichlet L-functions with shifted characters
Authors: Garunkštis Ramūnas
Published: December 2023

We study Dirichlet L-functions with shifted characters L(s, χ, H) = ⅀∞n=1 χ(n+H) ∕ ns, where H is an integer. Here we obtain a joint universality theorem for such functions.
Harmonic Bernoulli strings and random permutations
Authors: Manstavičius Eugenius
Published: December 2023

We examine fairly special b-harmonic Bernoulli strings appearing in n observations. It is shown that their count number can be used to define a random process converging to the Brownian motion as n tends to infinity. The proof is based upon the invariance principle for random permutations.
The estimate of fractional moments for Dirichlet L-functions
Authors: Zamarys Saulius
Published: December 2023

There is not abstract.
Spline curves on torus
Authors: Kazakevičiūtė Margarita , Krasauskas Rimvydas
Published: December 2023

There is not abstract.
Geometry of semi-nonholonomic hypercomplexes SNGr(1, 4, 5) in a four-dimensional projective space
Authors: Navickis Kazimieras
Published: December 2023

In this article the problem of intrinsic normalizations of plane distributions in an four-dimensional projective space is considered.
Business rules systems modelling with UML and rules enforcing in active relational databases
Authors: Vasilecas Olegas , Avdejenkov Vladimir
Published: December 2023

Business rules, control system of business rules, modelling of business rules by using UML diagrams and possibility to apply these systems of rules in the RDBVS are analysed in the article. Analysis showed that systems of rules could be modelled by UML and active rules of DBVS could be generated using model of rules. Possibility to describe priorities for rules, to determine conflicts between rules and recursions using UML diagrams was researched.
Lithuanian basic school students achievements in mathematics
Authors: Dudaitė Jolita
Published: December 2023

Lithuanian National Student Achievement Studies have been carried out for already two years. In 2002 Grade 6 students were tested, and in 2003, Grade 4 and Grade 8 students. Some of the main findings from their results in Mathematics are presented in the article, illustrated by several simple examples. It is noticed that a big number of students have problems in relation to understanding the fundamental concepts and having main skills in all the content areas of Mathematics.
Collaboration of the mathematicians of the Baltic and Nordic agricultural universities
Authors: Kaminskienė Janina , Raškinienė Danutė
Published: December 2023

In this paper we present the motives and the ways of cooperation between the Baltic and Nordic agri­cultural universities.
Contribution of M. Maknys to number theory
Authors: Laurinčikas Antanas
Published: December 2023

In the paper a survey of works in the number theory of M. Maknys is presented.
A limit theorem for partial weighted sums of regression residuals
Authors: Pažemys Vytenis
Published: December 2023

Let a linear regression be given. We consider the polygonal line process of weighted least squares residuals. We prove a limit theorem in Hoder spaces for this process. This extends the results of Jandhyala and MacNeill, Bischoff, Račkauskas.
Strategies of minimization of Sammon's mapping error
Authors: Dzemyda Gintautas , Bernatavičienė Jolita , Kurasova Olga , Marcinkevičius Virginijus
Published: December 2023

The classic algorithm for Sammon's projection and two new its modifications are examined in details. All the algorithms are oriented to minimize the projection error. The discovered new ways for minimization of the projection error makes a background for the further research in this field.
Bilateral Vocal Cord Paralysis Requiring Long-term Tracheostomy After SARS-CoV-2 Infection
Authors: Larrow Danielle Reny , Hartnick Christopher
Published: December 2023

Bilateral vocal cord paralysis can cause obstruction of glottic airflow, resulting in respiratory distress and the need for a surgical airway. We report a case of acute onset bilateral vocal cord paralysis in a healthy adolescent patient 9 days after a mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This 15-year-old patient presented with dyspnea, tachypnea, and stridor. A fiberoptic laryngoscopy revealed bilateral vocal fold paralysis with limited vocal cord abduction causing respiratory distress. A detailed set of diagnostic test results, including blood work, imaging, and a lumbar puncture, were all negative other than her new onset diagnosis of SARS-CoV-2 infection. The patient underwent tracheostomy placement with the subsequent resolution of her symptoms. Her vocal cord function remains impaired, and the patient continues to be tracheostomy-dependent 13 months after the initial presentation. SARS-CoV-2 infection has multiple well-established neurologic complications in children. The current case suggests that vocal cord paralysis may be an additional neuropathic sequela of the virus. Vocal cord pathology should be an important consideration when constructing a differential for children presenting with voice, swallowing, or breathing complaints after SARS-CoV-2 infection.
Determinanty dokonań polskich spółek publicznych w zakresie ESG
Authors: Bohdanowicz Leszek , Aluchna Maria
Published: December 2023

Dokonania w zakresie ESG i ich pomiar stają się w ostatnich latach kluczowymi elementami działalności spółek. Rośnie też liczba badań poświęconych działaniom spółek oraz raportowaniu na temat aspektów społecznych, środowiskowych i ładu korporacyjnego. Niniejszy artykuł wpisuje się w ten nurt. Jego celem jest zbadanie związków pomiędzy dokonaniami spółek (firm performance) w zakresie ESG polskich spółek giełdowych z indeksów WIG20, mWIG40 oraz sWIG80 a ich strukturami własnościowymi, wynikami finansowymi oraz wybranymi charakterystykami. Analiza regresji zgromadzonych danych pozwoliła stwierdzić, iż korzystny wpływ na dokonania spółek w zakresie ESG mierzone współczynnikiem ESG Score-Refinitiv mają wielkość spółki oraz własność zagranicznych akcjonariuszy.
Rola etyki zawodowej w kształceniu potencjalnych kandydatów na biegłych rewidentów
Authors: Renik Katarzyna
Published: December 2023

Celem niniejszego badania jest określenie roli etyki w zawodzie biegłego rewidenta w kształceniu potencjalnych kandydatów na studiach wyższych w Polsce. Badanie zostało przeprowadzone na podstawie krytycznej analizy literatury, aktów prawnych oraz analizy programów nauczania w postaci sylabusów polskich uczelni ekonomicznych. Mimo podkreślania znaczenia i roli etyki w zawodzie biegłych rewidentów, polskojęzyczne programy kształcenia uczelni ekonomicznych na kierunkach lub specjalnościach związanych z audytem, rewizją lub controllingiem oferują niewielką liczbę przedmiotów w zakresie etyki zawodowej. Badania literaturowe potwierdzają braki w edukacji w zakresie etyki wśród studentów (potencjalnych kandydatów). W związku z tym warto w przyszłości rozważyć rozszerzenie oferty kształcenia w celu zwiększenia wiedzy niezbędnej do zdobycia kwalifikacji i świadomości postaw etycznych potencjalnych kandydatów na biegłych rewidentów.
EXPERIMENTAL ACID-BASE PURIFICATION OF CARBONIZED RICE HUSKS: EXPLORING THE ADSORPTION EFFECTIVENESS OF UNVALUED RICE INDUSTRY RESIDUE
Authors: Crestani Larissa , Martins Sanderi Danielli , Vieira Yasmin , Luiz Dotto Guilherme
Published: December 2023

The burning of rice husks produces natural silica and generates charcoal with excellent properties for the adsorption of different pollutants. The objective of this study was to enhance the adsorption properties of this industrial residue from burning rice husk through acid and base purifications. The raw coal (RC) was initially modified with HCl(aq.) and then with NaOH(aq.), and subsequently renamed MC. Efficiency was verified by the adsorption of methylene blue (MB) dye, considering a concentration of 10 mg L-1, dosage of 0.05 g L-1, pH 6.7, and 120 min. MB removal was 78% for RC and 97% for MC, with experimental capacities of 144.78 mg g-1 and 180.78 mg g-1, respectively. The kinetics were better adjusted by Avrami (R2 0.99, error <2.8%). The properties of charcoal improved with the modification, presenting a more porous structure, greater surface area and functional groups that contributed to adsorption, proving that simple purification methods, such as acid-base purification, can be crucial for waste reuse.
Kanoniczna odpowiedzialność biskupa w związku z czynami podległych mu duchownych. Przestępstwa seksualne wobec małoletnich
Authors: Majer Piotr
Published: December 2023

The author’s research aims to resolve the issue of the nature of a bishop’s canonical liability in cases of pedophilic crimes committed by subordinate clergy. The monograph carefully investigates the provisions of canon law pertaining to such liability, both in the positive aspect (i.e., the obligation to take specific actions) and in the negative aspect (i.e., bearing the consequences of one’s unjust actions or negligence). The liability of the bishop is not solely derived from his position of hierarchical authority in the Church. It is not simply a result of the principle of‚ respondeat superior’. The liability in question is rather founded on the duty of the bishop’s pastoral care for the faithful entrusted to him. Canon law rejects the idea of institutional liability and anonymous or organizational fault. According to ecclesiological principles, the bishop’s liability must be based on concrete guilt proven to him ‘in eligendo’ or ‘in vigilando’.
Exploring the Potential of High Entropy Alloys: A Comprehensive Review on Microstructure, Properties and Applications: Part I
Authors: Arun S. , Radhika N. , Saleh Bassiouny
Published: December 2023

Over the past few years, there has been a notable surge in research interest surrounding high entropy alloys (HEAs) owing to their exceptional properties. Unlike conventional alloys, HEAs consist of five or more principal elements, which offer endless possibilities for developing new alloy systems. HEAs exhibit a high concentration of mixing elements, resulting in high disorderliness of the atomic structure within the material, known as high entropy. This unique nature provides HEAs with desirable properties, including excellent mechanical and physical properties at elevated temperatures, making them ideal for high-temperature applications like cryogenic engines and gas turbines. Moreover, HEAs have shown remarkable corrosion resistance, positioning them as viable options for applications in demanding environments such as marine settings, oil and gas pipelines and chemical processing plants. This comprehensive review paper analyses recent studies on various HEAs. Part I introduces HEAs and describes their synthesis, microstructure, hardness and strength properties.
TURBULENCE MODELING OF SHOCK BOUNDARY LAYER INTERACTION IN HYPERSONIC FLOW
Authors: Pirbastami Sogol , Pepper Darrell W. , Carrington David B.
Published: December 2023

Computational fluid dynamics (CFD) simulations of shockwave turbulent boundary layer interactions using different turbulence modeling including Reynolds-averaged Navier-Stokes (RANS) with different closures (Menter's k-ω-SST, and Spalart-Allmaras) have been investigated. The objective of the study is to assess the capability of current CFD codes, Ansys Fluent and STARCCM, to model hypersonic flow over a large hollow cylinder flare for Mach 6 with Re∞ = 5.33 × 107 The results of heat transfer and pressure data over the surface are presented for two-dimensional, axisymmetric, and three-dimensional RANS models using experimental data of LENS II high Reynolds number shock/Ludweig tunnel at the CUBRC center. Effects of properties of real gas, perfect gas, and different types of mesh have been considered for the assessment.
ELECTRON-BEAM SINTERING OF ZIRCONIUM DIOXIDE/TITANIUM CERAMICS FOR MICROELECTRONICS PRODUCTS
Authors: Klimov Aleksandr S. , Bakeev I. Yu. , Dolgova A. V. , Kokolov A. A. , Oks Efim M. , Zenin Aleksey A.
Published: December 2023

Zirconium dioxide (ZrO2) has excellent physical, chemical, and mechanical properties. These properties make it an excellent material for composite ceramics. High values of dielectric permittivity, mechanical resistance, and high radiation resistance allow it to be used to protect integrated circuits (ICs) from external influences. In this study, we fabricated ZrO2/titanium (Ti) ceramic composites by employing electron-beam sintering and a forevacuum-pressure plasma-cathode electron-beam source. We used a scanning electron microscopy method to study the properties of the ceramics after sintering. The results obtained showed that with an increase in the sintering temperature up to 1700°C, the Ti content in the near-surface layer of the composite decreased to almost 0. The depth of the region with low metal component content also increased with an increase in the sintering temperature and reached 2 mm in 3-mm-thick samples. This method can be used in the production of composite materials used in IC packaging.
URARTU YAZITLARINDAKİ DUA VE BEDDUALARA İŞLEVSEL BİR BAKIŞ
Authors: KÜÇÜKYILDIZ İshak
Published: December 2023

Yazının bulunmasından itibaren çeşitli yazıt ve belgelerde dua ve beddua kullanılmıştır. Dua ve beddualar, uygarlıkların ve toplumların değer yargılarını ortaya koyma ve inandıkları yüce varlıktan isteklerini veya istemediğini ifade etme şeklidir. Nitekim MÖ I. bin yılın ilk yarısında merkezi Tuşpa (Van) olmak üzere kurulan Urartu Devleti hakkında bilgiler edinebildiğimiz yazıtlarda da dua ve beddualarla karşılaşmaktayız. Urartu Yazıtları, gerek zaferleri anlatan gerekse yapmış oldukları imar faaliyetlerini göstermesi açısından çeşitlilik göstermektedir. Bu yazıtların bir kısmının Asurca, bir kısmının ise Urartuca olduğu anlaşılmaktadır. Yazıtlarda geçen dua ve bedduaların çeşitli amaçlara hizmet ettiği görülmektedir. Bu çalışmada işlevsel açıdan Urartu Yazıtları’nda geçen dua ve beddualar ayrıntılı olarak incelenmiştir. Yazıtlarda tespit edilen dua ve beddualar, mevcut düzenin devamlılığını sağlama, kutsala olan saygı, güç ve iktidar sahibi olma, yazıtları ve savaş araç gereçlerini koruma, toplumsal kuralları uygulatma ve propaganda gibi işlevler açısından ayrıntılı ele alınmıştır.
ÇOK DEĞİŞKENLİ GARCH MODELİYLE DÖVİZ KURLARINDA OYNAKLIK GEÇİŞİ
Authors: AYDIN Üzeyir
Published: December 2023

Bir finansal varlığın fiyatındaki değişkenliğe oynaklık denilmekte ve çoğunlukla standart sapma ile ölçülmektedir. Yüksek belirsizlik durumunda oynaklık artmaktadır. Bir piyasada yaşanan şokun diğer piyasalarda getiri ve oynaklık üzerindeki etkisi ise oynaklık geçişi olarak ifade edilmektedir. Uluslararası finansal piyasalarda oynaklık geçişi, 2008 yılı küresel krizinin etkileriyle birlikte önem kazanmıştır. Bu çalışmanın amacı, 1 Ocak 2015 tarihi itibarıyla Avrasya Ekonomik Birliğini oluşturan Belarus, Ermenistan, Kazakistan, Kırgızistan ve Rusya döviz kurları arasında oynaklık geçişini ortaya koymaktır. Söz konusu ülkelerin 31.12.2018 – 30.06.2023 tarihleri arasındaki döviz kuru günlük kapanış fiyatları üzerinden elde edilen getiri serileri MGARCH yöntemiyle analiz edilmiş, getiri oynaklıklarının haber etkisinin kaynak ülkeleri ile oynaklık geçişinin kaynak ülkeleri belirlenmiştir.
‘Information, Please’: Brian O’Nolan and the Radio
Authors: LaBine Joseph
Published: December 2023

This article proposes Irish radio broadcasting as an unexplored context for new directions in Flann O’Brien studies. Brian O’Nolan’s involvement in Irish radio spans at least two decades, from the early 1930s into the 1950s, yet the contributions of O’Nolan and his literary circle to Radio Éireann and the BBC remain an under-researched area of Flann O’Brien scholarship. Scholars are faced with the absence of a sound archive to refer to; but this article argues that such absences are part of the ephemeral nature of radio as a medium, and that we must view O’Nolan’s work in radio as an emerging, amateur practice within a wider, sustained artistic project. Though we cannot resurrect the live performances themselves, the article draws on new archival evidence to offer a short history of O’Nolan’s radio appearances. It attempts to fill the gaps produced by lost media with original radio schedules, reviews, letters, and typescript drafts, and by contextualising O’Nolan’s portrayals of radio within a wider social and technological milieu, via the radio-related activity of his circle (Niall Sheridan, Donagh MacDonagh, Niall Montgomery). This context helps us to see how radio aesthetics influenced O’Nolan’s metafictional writing, as demonstrated through close readings of how the modernist ‘radio’ mode informed ‘!CEÓL!’ (1932), Blather (1934), and At Swim-Two-Birds (1939).
On the Solid Rod Dynamics in the Lobachevsky Space
Authors: Makeev Nikolay N.
Published: December 2023

An absolutely solid infinitely thin rectilinear immaterial finite length rod helical motion problem is considered. Motion is heical relative to the inertia center. Located at rod ends point masses are identiall. The rod movement occurs in the constant negative curvature space (Lobachevsky space) under the gyroscopic forces system influence and a constant tracking force. The gyroscopic forces structure is set with using special conditions, which contain six characteristic constant parameters (gyroscopic coefficients). The characteristic motion properties are given. Components analytical dependense on the kinematic rod screw, rod orientation parameters is founded. Expressions of these parameters as time function, are obtained.
Scientometrics and academia
Authors: Zerem Enver , Vranić Semir , Hanjalić Kemal , Milošević Dejan B.
Published: December 2023

The social significance and quality of every human activity are proportional to its usefulness to the social community. Science belongs to the very top of the processes and events in the history of humankind that strongly influenced the development of society, which over time transformed it and contributed to the common good. Science produced new knowledge that made it possible for billions of people to rise out of poverty, develop industrialization and mass communication, eradicate many dangerous diseases for humankind, and enable humans to leave their footprints on the moon. Science is a human activity that produces new knowledge presented through innovations, patents, and publications, aimed at solving the problems facing humanity.
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Diamond XChem Seeding Protocol v1
Authors: Marples Peter , not provided daren.fearon , Tomlinson Charlie
Published: December 2023

The use of seeding in protein crystallisation is a highly effective method for increasing the quantity of usable crystals from a single plate and can be crucial for obtaining crystals in a highly reproducible manner. Even crystallisation experiments which did not previously require seeding can benefit from the use of seeds when transferring protocols between labs.
Visium Direct Mount FFPE -- University of Minnesota TMCs v1
Authors: J Niedernhofer Laura
Published: December 2023

The Visium Spatial Gene Expression for FFPE is designed to measure mRNA in tissue sections derived from formalin fixed & paraffin embedded (FFPE) tissue samples and requires a Visium Spatial slide with intact tissue sections as input. Tissue sections are processed with Visium Spatial Gene Expression assay performed by the University of Minnesota Imaging Center and sequenced by the University of Minnesota Genomics Center.
From the Misreading of a Sixteenth-Century Sketch to an Exquisite Evidence of Constantine’s Nea Roma
Authors: Turković Tin , Maraković Nikolina
Published: December 2023

Through the past decades, there have been many attempts to reconstruct Constantine the Great’s Forum in Constantinople – his Nea Roma, and to decipher its intended symbolical meaning. Most of these attempts were fruitful to some extent, but the entire message that the Emperor wanted to convey through the specific arrangement of the Forum has never been fully and clearly explained. Moreover, the Middle and Late Byzantine literary sources have additionally obscured the original message, so each piece of evidence about Constantine’s original concept of the Forum is extremely valuable. This paper should thus be a contribution to the understanding of its original symbolism, based on a piece of evidence that has often been either circumvented or ignored by the researchers: the unique drawing of the pedestal of Constantine’s porphyry column, made by Danish artist Melchior Lorichs (1526/27 – after 1583). The pedestal was decorated with an elaborate relief, whose proper interpretation becomes an important clue for deciphering Constantine’s imperial agenda. So, the paper offers a new interpretation of the relief, and establishes its importance in the symbolical framework of the Forum.
CCND1 and PTEN genes as markers of progression in vulvar cancer
Authors: Busarova A. V. , Petrusenko N. A. , Kruze P. A. , Porhanova N. V.
Published: December 2023

Purpose of the study. Studying the relative copy number of 12 genes: MYC, PTEN, CCND1, PIK3CA, TP53, CDKN2A, MDM2, MCL1, NFKBIA, MTAP, BIRC2, KMT2C, to search for potential prognostic cancer markers in vulvar cancer (VR).

Patients and methods. The study included 50 patients aged 29–80 years with the diagnosis of squamous cell carcinoma of the vulva without metastases – group 1 (n = 25) and with metastases to the lymph nodes – group 2 (n = 25). Total DNA from paraffin blocks of tumor and conditionally healthy vulvar tissue served as the material for the study. The relative copy number of genes (RCQ) was assessed using the RT-qPCR method: MYC, PTEN, CCND1, PIK3CA, TP53, CDKN2A, MDM2, MCL1, NFKBIA, MTAP, BIRC2, KMT2C and reference

genes: GAPDH and B2M. Raw RT-qPCR data were analyzed using Bio-Rad CFX Manager software (ver. 2.1). RCQ of the genetic locus was calculated using the formula 2-ΔCt. Analysis of the significance of differences included determination of the OR (CI 95 %), Chi-square, Mann-Whitney U-test. Differences were considered statistically significant at p < 0.05.

Results. Amplification was observed for 9 genes: MYC (48 % of cases), MCL1 (39 %), NFKBIA (46 %), CCND1 (52 %), PIK3CA (48 %), TP53 (62 %), MDM2 (40 %), BIRC2 (54 %), KMT2C (42 %); losses were recorded for 3 genes PTEN (44 % of cases), MTAP (32 %), CDKN2A (36 %). In the 2nd group of patients, a statistically significant 1.7-fold increase in RCQ of the CCND1 gene (p < 0.05) and a 1.9-fold decrease in RCQ of the PTEN gene (p < 0.05) were found.

Conclusion. In the study, CCND1 amplification events and/or PTEN loss were associated with lymph node metastasis in RV patients. Thus, the copy numbers of these genes may serve as prognostic markers of the disease.
Metabolic profile in patients with prostate cancer
Authors: Pomeshkin E. V. , Smirnov A. V. , Popov S. V. , Orlov I. N. , Bragin-Maltsev A. I.
Published: December 2023

Purpose of the study. To evaluate the levels of metabolic markers in patients with prostate cancer (PCa) in comparison with patients with benign prostatic hyperplasia (BPH).

Patients and methods. 108 patients were included in the study. The majority of patients had comorbidities: coronary heart disease, hypertension, and almost one third of patients had type 2 diabetes mellitus. Median (Me) age was 67 (64–74), body mass index was 25.9–34.7. The main study group included 54 patients with histologically verified prostate cancer, the comparison group consisted of 54 patients with benign prostatic hyperplasia (BPH). The level of basic biochemical parameters, glomerular filtration rate, lipidogram, total prostate-specific antigen (PSA), total testosterone was determined in all patients.

Results. When comparing anamnestic and biochemical parameters, the groups were not statistically significantly different. When comparing the groups by lipid status, it turned out that in the group with RPW, in contrast to the group of patients with BHP, statistically significantly higher levels of total cholesterol (5.13 (3.3–10,4) and 4.60 (2.5–6.3)) mmol/L, respectively, p = 0.023), low–density lipoproteins (2.93 (0.8–5.9) and 2.60 (0.9–4.2) mmol/L, respectively, p = 0.035), triglycerides (2.10 (1.0–8.0) and 1.70 (0.5–7.3) mmol/L, respectively, p = 0.048). In case of dyslipidemia, an increased risk of developing PCa was identified. Correlation analysis revealed a direct moderate relationship between total PSA levels and total cholesterol concentration (r = 0.51).

Conclusion. Our study revealed that in the PCa group, there was a higher level of total cholesterol, low-density lipoproteins, and triglycerides, in contrast to the group of patients with BPH. Additionally, in the group of patients with BPH, dyslipidemia was a risk factor in the development of PCa, which should be taken into account in PCa prevention and diagnosis.
Study of the effectiveness of vacuum-aspiration breast biopsy in patients with complete clinical response after neoadjuvant polychemotherapy in complex treatment of breast cancer
Authors: Maksimov K. V. , Bagdasarova D. V. , Zikiryakhodzhaev A. D. , Kolomeytseva A. A. , Mazo M. L. , Surkova V. S. , Usov F. N. , Eremeeva I. A. , Gerasimov A. N.
Published: December 2023

Purpose of the study. Evaluation of the diagnostic value of vacuum-assisted biopsy (VAB) based on pathomorphological studies in patients with breast cancer (BC) who have achieved a complete clinical response (cCR) after neoadjuvant polychemotherapy (NACT).

Patients and methods. In the study, conducted from 2021 to 2023 at the P. A. Hertsen Moscow Oncology Research Institute – a branch of the National Medical Research Radiology Center of the Ministry of Health of Russia, 35 patients with BC cT1–3N0–3M0 of various molecular-biological types who were diagnosed with cCR after NACT were included. All patients underwent VAB (needle size 7–10 G) of the breast followed by histological examination, after which surgical treatment was performed. Subsequently, histological conclusions of VAB and surgical materials were compared with each other for the presence and degree of pathomorphological response.

Results. According to the pathomorphological conclusion when conducting VAB, the following results were obtained: 1 – true positive, 29 – true negative, 3 – false negative, and 0 – false positive. No statistically significant results of the association between complete pathomorphological response and the molecular-biological type of breast cancer were obtained (p > 0.05), however, there is a tendency towards the greatest number of complete pathomorphological responses in Her2-neu-positive (luminal – 100 %, non-luminal – 90.9 %) and triple-negative (87.50 %) types of breast cancer. The overall sensitivity of the method was 25.0 % (CI 6.8–60.2 %); specificity – 100 % (CI 88.1–100 %); false-negative result (presence of tumor cells in the surgical material and a negative result of VAB) – 9.1 % (CI 3.4–20.2 %); false-positive result (absence of tumor cells in the surgical material and a positive result of VAB) – 0 % (CI 0–10.6 %). The overall diagnostic accuracy of the method was 90.9 % (CI 79.8–96.6 %).

Conclusion. The results of the conducted research allow for the consideration of excluding surgical treatment when a complete pathomorphological response is obtained by VAB. However, further research is required with the inclusion of a larger number of patients.
Surface-enhanced Raman spectroscopy in women with benign and malignant endometrial diseases
Authors: Zuev Vladimir M. , Lystsev Dmitrii V. , Artem’ev Dmitrii N. , Bratchenko Lyudmila A. , Kukushkin Vladimir I. , Fedorova Tat’yana A. , Bystrykh Oksana A. , Ishchenko Anton A. , Gilyadova Aida V.
Published: December 2023

Background. This study aimed to enhance early detection of endometrial cancer in women and distinguish benign conditions from endometrial cancer using surface-enhanced Raman scattering (SERS) analysis of blood plasma, thus increasing diagnostic efficacy.
Materials and methods. The study of blood plasma from 95 female patients aged 22–79 years was performed. The patients were divided into four groups: group 1 included 29 women with endometrial adenocarcinoma, group 2 included 31 patients with endometrial polyp, group 3 included 10 women with endometrial hyperplasia, and the comparison group consisted of 25 healthy women. Blood plasma was analyzed via SERS, with three Raman spectra recorded per sample. Spectral measurements of the SERS substrate were assessed using dried samples on an experimental bench equipped with the spectrometric system RL785 (LLC “Foton-Bio”, Russia), incorporating a CCD detector, laser radiation source with a wavelength of 785 nm, and ADF U300 microscope (ADF, China). A silver substrate composed of dried silver colloid was used to demonstrate the enhancement effect on the Raman signal from the surface of the blood plasma.
Results. Spectral and specific features that distinguish adenocarcinoma, polyps, and endometrial hyperplasia were identified and evaluated. Spectral and quantitative differences specific to each condition, which are crucial for the differential diagnosis of pathologic tissues, were also identified. The accuracy rates of the optical diagnostics in distinguishing endometrial adenocarcinoma from the control group and endometrial hyperplasia were 87% and 85%, respectively, for the calibration and verification spectral sets (where the sensitivity and specificity were 66% and 92% for the spectral verification set, respectively). The accuracy rates of distinguishing control from endometrial hyperplasia and endometrial adenocarcinoma were 86% and 85%, respectively, and the accuracy of distinguishing endometrial hyperplasia from control and endometrial adenocarcinoma was 81% for the calibration and verification sets of spectra. In addition, the study demonstrated improved accuracy in differentiating adenocarcinoma from hyperplasia, including polyps. The accuracy rate was 93% in the calibration set of spectra, with sensitivity and specificity of 96% and 90%, whereas in the validation set, it was 91%, with sensitivity and specificity of 93% and 88%, respectively.
Conclusions. The study demonstrated the potential use of SERS for differentiating expression patterns in endometrial cancer from those in benign conditions.
Clinical experience with postpartum treatment of a patient with arteriovenous malformation of uterine vessels
Authors: Busygina Liliya A. , Serova Ol’ga F. , Garaeva Liliya R. , Bakhtiyarov Kamil’ R. , Isaev Abdurahman К. , Barinova Irina V. , Abdullazhonov Abror O.
Published: December 2023

Uterine arteriovenous malformation is a rare vascular dysplasia where the uterine veins communicate with the branches of arteries of varying calibers. Patient K., a 37-years-old patient, presented with genital tract bleeding. Her medical history included operative labor at 37 weeks with dichorionic diamniotic twins, with the placental site on the posterior uterine wall exhibited firm attachment. The uterine cavity walls were scraped, and the bleeding vessel in the placental site was sutured. The blood loss amounted to 750 mL, and reinfusion was conducted. Fourteen days after giving birth, a heavy bloody discharge with blood clots from the genital tract occurred. The blood tests revealed no abnormalities. Echography detected multiple tubular structures that were anechoic on the posterior wall of the uterus, from the endometrium to the serosa, with the CDC mode blood flow. Magnetic resonance angiography revealed hypervascularization with premature arteriovenous discharge. Superselective embolization was performed on uterine artery afferents, and complete blood flow reduction was achieved, leading to the cessation of bleeding. On postoperative day 17, the patient experienced considerable bloody discharge from the genital tract, causing the hemoglobin level to decrease to 88 g/L. The presence of an arteriovenous malformation in the uterine vessels accompanied by ineffective embolization necessitated uterine extirpation. The postoperative phase was uneventful, and the patient was discharged from the hospital in satisfactory condition, with no evidence of anemia (hemoglobin, 115 g/L).