bluuebunny/crossref_metadata_2025 huggingface dataset:
The relationship between time management, job satisfaction, and job burnout among Jordanian medical staff during COVID-19
Authors: Alziyadat Zaid , Obidat Ahmad
Published: December 2022

COVID-19 has put pressure on medical crews to respond rapidly and operate in real time, which could affect their job performance. However, adopting time management practices appear to mitigate adverse job outcomes and capitalize on positive ones. Therefore, by adopting the integrative time management model, this study analyzes the relationship between time management (setting goals and priorities and mechanics dimensions), job satisfaction, and job burnout (emotional exhaustion dimension) among Jordanian medical staff during COVID-19. The data were gathered via an electronic questionnaire. In total, 737 respondents participated in the survey. RStudio-2022.07.1 was utilized to code all statistical analyses, including a description of demographics and structural equation modeling. Results revealed that while the setting goals and priorities dimension (z = 4.641, p = 0.000) positively relates to job satisfaction, the mechanics dimension has the opposite effect (z = 1.887, p = 0.059). Moreover, while the setting goals and priorities dimension (z = 2.369, p = 0.018) is positively related to the emotional exhaustion dimension, the mechanics dimension (z = –2.086, p = 0.037) is negatively related. Finally, it was found that job burnout does not affect job satisfaction (z = –0.645, p = 0.519). The findings imply that medical institutions should support their staff in setting goals and priorities to accomplish their tasks and encourage time management. Finally, medical staff should have the training to help them overcome any stress they experience when they plan their work-related tasks.
Structural optimization of sectoral exports from the perspective of water footprint: A study from Henan Province, China
Authors: Wen Faguang , Khanal Ribesh , Fang Xue , Shan Ang
Published: December 2022

Water used for production is the primary consumer of regional water. Water footprint reflects the actual water consumption of each product, which can reflect the intensity of water consumption of each production sector and the flow of water resources implied in the product trade. In this paper, the water footprint of each sector in Henan Province in 2017 was calculated using non-competitive input-output techniques. Furthermore, a dual-objective planning model that minimizes water resource export and maximizes labor compensation was established, based on which the export structure of the sector in the province was optimized. Research findings show that agriculture is the primary consuming sector of water resources from the direct water use perspective. In comparison, the food processing industry is the major consuming sector of water resources from the water footprint perspective. The difference in water resources consumed by sectors from the perspective of water footprint is smaller than that from the perspective of direct water use. Second, most water-intensive sectors have a relatively large water footprint of out-of-province use, which results in 52.75% of Henan Province's produced water being consumed outside the province. Third, the current export structure adjustment of sectors in Henan Province can achieve a Pareto improvement of water conservation and economic development. It is expected to save 14.65% of the province's export water resources and increase Henan Province's total exports by 170.61 billion (170.61 × 109) yuan and increase labor compensation by 39.76 billion yuan. This study can be used to optimize water allocation and improve sustainable water use in water-scarce regions.
4-Aminocoumarin Derivatives as Multifaceted Building Blocks for the Development
of Various Bioactive Fused Coumarin Heterocycles: A Brief Review
Authors: Patra Prasanta , Patra Susanta
Published: December 2022

Aminocoumarins are found to be present in many natural products, pharmaceuticals,
and organic materials. These derivatives demonstrate numerous biological activities including
DNA gyrase, anti-proliferative and anti-breast cancer activities. Among the allaminocoumarin
derivatives, 4-aminocoumarin derivatives have been reported to exhibit anticancer
and anti-fungal properties. 4-Aminocoumarins and their derivatives are important precursors
for the synthesis of coumarin fused N-heterocycles. Due to the presence of an amino
group as well as enamine carbon, it is very reactive towards electrophiles and in most of the
cases, it has a higher tendency to cyclize immediately by the various reaction path ways and
provides the heterocyclic products. Unlike other aromatic amines, it did not give any Schiff
base on reaction with aldehydes or ketones. Lamellarins, ningalin A, ningalin B, schumanniophytin,
santiagonamine, goniothaline, and polyneomarline C are important natural coumarin fused N-heterocycles
and show excellent biological activities, including antitumor, reversal of multidrug resistance, anti-HIV, wound
healing, anti-malarial, anti-hepatitis, and anti-syphilis activities. The synthesized coumarin fused N-heterocycles
have been reported to display Topoisomerases I inhibitory, DYRK1A inhibitory, and anti-cancer activities. Most of
the syntheses of pyrrolo/imidazolo/indolo[3,2-c]coumarin, pyrido/quinolino[3,2-c]coumarins, pyrimidino[
c]coumarin and oxazino[c]coumarin have been synthesized easily from 4-aminocoumarin. This paper reviews
the research data in the literature on the synthesis of bioactive coumarin fused heterocycles using 4-aminocoumarin
derivatives over the period of 2-3 decades. It covers the synthetic applicability of 4-aminocoumarin for the development
of coumarin fused 5-, 6-, and 8-membered ring derivatives via classical reaction protocols, microwavemediated
reactions, organo-catalyzed reactions, transition metal-catalyzed reactions, and green reaction protocols.
Human Orphan Cytochromes P450: An Update
Authors: Molina-Ortiz Dora , Torres-Zárate Carmen , Santes-Palacios Rebeca
Published: December 2022

Orphan cytochromes P450 (CYP) are enzymes whose biological functions and substrates are unknown.
However, the use of new experimental strategies has allowed obtaining more information about their relevance in the
metabolism of endogenous and exogenous compounds. Likewise, the modulation of their expression and activity has
been associated with pathogenesis and prognosis in different diseases. In this work, we review the regulatory pathways
and the possible role of orphan CYP to provide evidence that allow us to stop considering some of them as
orphan enzymes and to propose them as possible therapeutic targets in the design of new strategies for the treatment
of diseases associated with CYP-mediated metabolism.
Phage Therapy as a Protective Tool Against Pathogenic Bacteria: How Far
We Are?
Authors: Chakrabarti Alok Kumar , Singh Kushagri , Biswas Asim , Dutta Shanta
Published: December 2022

Bacterial infections continue to jeopardize human and animal health, impacting millions
of lives by causing significant deaths every year. The use of antibiotics remains the primary choice
of therapy and has only been partly successful in reducing the disease burden due to the evolving
nature of resistant microbes. Widespread and inappropriate use of antibiotics resulted in the development
of antibiotic-resistant microbial species provoking substantial economic burdens. The most
promising way to resolve the issue of antibiotic resistance is the use of bacterial viruses called bacteriophages
to treat microbial infections. Earlier reports on experimental bacteriophage therapy
showed successful patient outcomes, and many clinical trials of such clinical bacteriophages have
already been investigated in many western countries. In this review, we are focusing on the advantages
as well as drawbacks of bacteriophage therapy to use it as an alternative to antibiotics for microbial
infections, together with its current success status. There is also a need to extensively study
the past, present, and future outlook of phage therapy in comparison to presently available antimicrobial
agents and especially immunological response by the host after phage administration. Our
aim is to highlight the fast-promoting field of bacteriophage therapy and provocations that lie ahead
as the world is gradually moving aside from complete dependence on antimicrobial agents.
Montelukast Inhibits Lung Cancer Cell Migration by Suppressing
Cysteinyl Leukotriene Receptor 1 Expression In vitro
Authors: Wei Shuo , Chen Yisheng , Zhang Jinye
Published: December 2022

Background:

Lung cancer is a major threat to public health and remains difficult to treat. Repositioning of existing drugs has emerged as a therapeutic strategy in lung cancer. Clinically, low-dose montelukast has been used to treat asthma.

Objective:

We evaluated the potential of using montelukast to treat lung cancer.

Methods:

Migration was detected using wound-healing and Transwell assays, the expression of CysLT1 using western blotting, and subcellular localization of CysLT1 using immunofluorescence. CRISPR/Cas9 technology was used to further investigate the function of CysLT1.

Results:

Subcellular localization staining showed that the CysLT1 distribution varied in murine and human lung cancer cell lines. Furthermore, montelukast suppressed CysLT1 expression in lung cancer cells. The treated cells also showed weaker migration ability compared with control cells. Knockout of CysLT1 using CRISPR/Cas9 editing in A549 cells further impaired the cell migration ability

Conclusion:

Montelukast inhibits the migration of lung cancer cells by suppressing CysLT1 expression, demonstrating the potential of using CysLT1 as a therapeutic target in lung cancer.
KCa-Related Neurological Disorders: Phenotypic Spectrum and Therapeutic
Indications
Authors: Zahra Aqeela , Liu Ru , Han Wenzhe , Meng Hui , Wang Qun , Wang YunFu , Campbell Susan L. , Wu Jianping
Published: December 2022

Although potassium channelopathies have been linked to a wide range of neurological con-
ditions, the underlying pathogenic mechanism is not always clear, and a systematic summary of clini-
cal manifestation is absent. Several neurological disorders have been associated with alterations of
calcium-activated potassium channels (KCa channels), such as loss- or gain-of-function mutations,
post-transcriptional modification, etc. Here, we outlined the current understanding of the molecular
and cellular properties of three subtypes of KCa channels, including big conductance KCa channels
(BK), small conductance KCa channels (SK), and the intermediate conductance KCa channels (IK).
Next, we comprehensively reviewed the loss- or gain-of-function mutations of each KCa channel and
described the corresponding mutation sites in specific diseases to broaden the phenotypic-genotypic
spectrum of KCa-related neurological disorders. Moreover, we reviewed the current pharmaceutical
strategies targeting KCa channels in KCa-related neurological disorders to provide new directions for
drug discovery in anti-seizure medication.
Immunotherapy-Associated Hypophysitis under Anti-PD1: Two Case
Reports
Authors: Ma Jing , Shen Xinyu , Yang Minglan , Xu Hua , Zhou Huan , Wang Liwei
Published: December 2022

Background:

Immunotherapy-associated hypophysitis is an uncommon adverse event.
However, if not handled properly, it could lead to fatal sequelae.

Case Presentations:

Case 1. A 66-year-old man presented to our hospital with hyponatremia. He
had low plasma levels of adrenocorticotropin and cortisol. The patient had a history of non-small
cell lung cancer and had undergone 16 cycles of immunotherapy with sintilimab, a monoclonal
antibody against programmed cell death protein 1 (PD1). He was diagnosed with adrenal insufficiency
secondary to immunotherapy-associated hypophysitis and received a physiological dose of
glucocorticoids. Upon discharge, he has prescribed a continued course of hormone replacement
therapy combined with immunotherapy. Case 2. The second case profiled here involved a 58-
year-old patient diagnosed with gastric antrum cancer. After ten months of immunotherapy with
carrelizumab, a human high-affinity immunoglobulin G4 (IgG4) anti-PD-1 monoclonal antibody
drug, the patient was referred to the Endocrinology Department at our medical centre for adrenal
nodules and intolerance of anorexia. He also suffered from hypophysitis and was prescribed hormone
replacement therapy combined with immunotherapy.

Conclusions:

This article discusses the clinical characteristics, diagnosis, treatment, and subsequent
follow-up for immunotherapy-associated hypophysitis in the context of two case reports.
Based on our findings and observations, we conclude that patients with immunotherapy should
regularly be referred to endocrine-related follow-up during tumour treatment.
Pharmacological Activity and Mechanisms of Action of Terpenoids from
Laurus nobilis L.
Authors: Kamdem Boniface Pone , Le Doux Kamto Eutrophe , Soh Désiré , Pegnyemb Dieudonné Emmanuel , Zingue Stéphane , Paumo Hugues Kamdem , Katata-Seru Lebogang Maureen , Abou Aboubakar , Rosinah Montsho Maiyane , Mbah James Ajeck , Boyom Fabrice Fekam
Published: December 2022

Native to the Southern Mediterranean region, Laurus nobilis L. (Family Lauraceae) is an
evergreen shrub or tree found in warm climate regions with high rainfall. The leaves and essential
oil of this plant have been widely used as condiments, spices, and flavoring agents in the culinary
and food industries. The whole plant is also used for the traditional treatment of various diseases,
including cough, asthma, hemorrhoids, rheumatic pain, diarrhea, intestinal, and cardiac diseases.
Previous phytochemical investigation of this plant demonstrated the presence of a variety of secondary
metabolites, especially terpenoids. The present study aims to critically analyze comprehensive
literature on the pharmacological activity and mechanisms of action of terpenoids from Laurus nobilis
L. The available information on the pharmacological activity of terpenoids from L. nobilis L. was
obtained from textbooks, theses, as well as published articles through a variety of libraries and electronic
databases. The present study demonstrated that L. nobilis is rich in terpenoids, with more than
200 entities identified in reported studies. Terpenoids from L. nobilis have shown a wide range of
pharmacological activities, including anti-inflammatory, antidiabetic, antifungal, antibacterial, immunomodulatory,
anticonvulsant, antioxidant and cytotoxic activities. The mechanisms of action of
most of these terpenoids included the imbalance of the ionic permeability of the cell membrane (anti-
inflammatory and antimicrobial activities), modulation of the effects of gamma-aminobutyric acid
(GABA) nergic neurotransmission (anticonvulsant activity), and the inhibition of inflammatory
responses, prevention of metastasis, and induction of apoptosis (cytotoxic effect), among others.
Referring to in vitro studies, terpenoids of L. nobilis L. have shown a variety of biological activities.
However, more cytotoxic and in vivo studies and detailed mechanisms of action of the bioactive
terpenoids are recommended.
DESIGN THINKING PROCESS IN SME, IS IT STILL POWERFUL IN DEALING WITH THE COVID 19 MARKET TURBULENCE?
Authors:   Universitas Ciputra Surabaya, Indonesia, Efrata Tommy C. , Radianto Wirawan E. D. ,   Universitas Ciputra Surabaya, Indonesia, Nahar Faiza Husnayeni ,   Economics Department, Universidad de Granada, Spain
Published: December 2022

Studies on SME new product development utilizing the design thinking methodology during the pandemic have received little attention from academics. This study aims to examine how a firm’s new product and performance are impacted by the design thinking process. The study was carried out at the height of Covid-19’s market dominance. Data was gathered using an online survey of 187 SMEs from diverse industries located throughout Indonesia. Purposeful sampling is conducted to find the chosen companies, particularly those that have altered their business model or added new products. The data is then analysed and modelled using SEM-PLS to determine how the concepts connect. This study discovered that SMEs can still use the design thinking method to assist them in coping with the effects of the pandemic. It has also been demonstrated that market volatility makes the design thinking method less effective. The study highlights the significance of a firm’s absorptive capacity for fostering the design-thinking process. The results of this study demonstrate how design thinking helps a business succeed during a period of significant changes in customer behaviour, bridging a knowledge gap. The study’s conclusions might help SMEs modify their business practices during and after the pandemic.
INFLUENCE SOCIAL MEDIA MARKETING ACTIVITIES AGAINST BRAND LOYALTY DIRECTLY OR THROUGH CONSUMER SATISFACTION AND BRAND EQUITY ON THE LARGEST E-COMMERCE IN INDONESIA
Authors:   Trisakti University, Indonesia, Daya Mardiana , Siagian Yolanda Masnita ,   Trisakti University, Indonesia, Kurniawati Kurniawati ,   Trisakti University, Indonesia
Published: December 2022

Social Media Marketing is all strategic formations in sales communication carried out through social media. Social Media Marketing is considered more effective than traditional marketing communications such as print or electronic media, so Social media marketing is considered to be able to increase brand loyalty which has an impact on customers who will consistently use the product repeatedly, will inform, and even recommend the product to others. This study analyzes the influence of Social Media Marketing on Brand Loyalty directly and its effect through the mediation of consumer satisfaction & Brand equity on Brand Loyalty. The sample was taken from 195 followers of the Instagram account of the largest e-commerce platform in Indonesia, including Tokopedia, Shopee, Lazada, Bukalapak, OLX, and others. The research uses quantitative methods with an explanatory research approach, while hypothesis testing is carried out with SEM (Structural Equation Model) analysts. The research shows that social media marketing has a direct and significant effect on brand equity and consumer satisfaction, but social media marketing has no effect on brand loyalty. Brand equity has a direct and significant effect on brand loyalty, but consumer satisfaction has no effect on brand loyalty. From this research, it was found that it is so important to optimize the use of social media marketing to reach a wider scope. Attractive social media marketing can influence consumer perceptions to form a good impression of a brand. Previous research stated that an increase in social media activity and brand equity affects consumers’ desire to buy products, an increase in brand equity will also impact high brand loyalty. However, it needs to be re-examined to find out the addition of the right variable as mediation to see the influence between customer satisfaction on brand loyalty and social media marketing on brand loyalty.
AN EMPIRICAL ANALYSIS OF FACTORS INFLUENCING PERFORMANCE OF SHARIAH MUTUAL FUNDS IN INDONESIA
Authors:   Perbanas Institute, Indonesia, Marsono A. Dewantoro , Salim Ubud ,   Fakultas Ekonomi dan Bisnis, Universitas Brawijaya, Indonesia, Ratnawati Kusuma ,   Fakultas Ekonomi dan Bisnis, Universitas Brawijaya, Indonesia, Aisjah Siti ,   Fakultas Ekonomi dan Bisnis, Universitas Brawijaya, Indonesia
Published: December 2022

This paper aims to identify the factors that affect the performance of shariah mutual funds. This study uses SEM to test the factors that hypothetically influence mutual fund performance, namely mutual fund manager skills, characteristics, and analyst coverage. This study uses a sample of 45 mutual funds registered with the OJK [financial services authority] for at least three years: equity funds, fixed-income funds, and mixed funds. The results indicate that fund manager skills negatively influence mutual fund performance but not significantly. In addition, the characteristics positively affect the mutual fund performance but are insignificant. Last, analyst coverage is positively influencing the mutual fund performance significantly. The results provide information that would benefit the investors in predicting the performance of shariah mutual funds and the fund managers to improve the performance of their managed funds. Further research will ascertain the inability of market-timing skills and asset allocation strategies to improve mutual fund performance.
CRISIS LEADERSHIP: THE ART OF NAVIGATING ORGANIZATIONAL CHANGE DURING THE COVID-19 PANDEMIC
Authors:   Human Resource Development, Post Graduate School, Universitas Airlangga, Indonesia, Prihatini Tatik , Iswati Sri ,   Universitas Airlangga, Indonesia, Suaedi Falih ,   Universitas Airlangga, Indonesia
Published: December 2022

Organizational transformation is one of the steps leaders can take to survive and adapt to the current situation. Organizations that do not transform in a certain period will be left behind, even collapse, because of the dynamic nature of consumers and markets. Trans- formation is driven by internal factors such as the need for efficiency, revenue enhancement, and increasing employee prosperity. Meanwhile, external factors that trigger transformation include competition with competitors, technological advancement, and demand for adaptation to consumer needs and desires changes. Leaders have many references to adopt for navigating transformation in the normal situation. However, they have few references on navigating transformation in the Covid-19 pandemic situation. The Covid-19 pandemic has implied implementing a remote working system to minimize viral transmission. Such a system poses many challenges to leaders and employees as they have never practiced it. Failure of the leaders to navigate transformation will seriously harm the organization and even lead to collapse. The present study aims to identify some applicable competencies for leaders in navigating organizational transformation during the pandemic. This study used a qualitative method with semi-structured interviews as the data collection technique. The thematic analysis was conducted to analyze responses from interview questions. 14 informants were involved in this study. They consisted of general and senior managers transforming the pandemic situation. The results of this study revealed four major competencies, namely task competencies, human relation competencies, adaptive competencies, and virtual competencies in navigating transformation during the pandemic situation.
THE FACTOR OF AWARENESS AND PURCHASING DECISION OF ICE CREAM BASED ON HALAL LABEL
Authors:   Master Program in Management, Faculty of Economics and Business, Universitas Brawijaya, Indonesia, Ulya Muhammad Ziauddin , Rohman Fatchur ,   Faculty of Economics and Business, Universitas Brawijaya, Indonesia, Sunaryo Sunaryo ,   Faculty of Economics and Business, Universitas Brawijaya, Indonesia
Published: December 2022

The increasing Muslim population affects the demand for halal products. Multinational companies cannot see the current trend of Muslim consumer growth by looking at the decision-making of halal food and beverage purchases and brand awareness. This study examines the influence of religion, halal labeling, information delivery, and health considerations on brand awareness and purchasing decisions for Wall’s ice cream in Malang. This research is explanatory research with 180 respondents. Data were collected using a questionnaire, and the size used a Likert scale. This paper uses the Structural Equation Model (SEM) for data analysis with the Variance Based SEM approach, commonly known as Partial Least Square (PLS). The results showed that two variables had no significant effect: exposure to information and health labels. And considering that the independent variables in this study are essential in influencing purchasing decisions, it is hoped that the results of this study can be used as a wish for further research.
Pedagogical Supervision in the Higher Education Study Process
Authors:   Liepaja University, Stieģele Dace , Miķelsone Ilze ,   University of Latvia
Published: December 2022

When starting studies, support that can be implemented in individual and group supervision is important for the development of students’ personalities and academic competence. The article aims to reveal the essence of pedagogical supervision and its application in the higher education study process. The research was implemented as a theoretical study, during which the analysis of selected sources – professional and scientific literature, research on supervision, and pedagogical supervision was performed, using induction, deduction, and comparison methods. The following keywords were used to search for data sources: pedagogical supervision, supervisee, supervision, supervisor, education, higher education. A total of 32 data sources were selected. As a result of the theoretical research, a matrix of explanations of the concepts of supervision, pedagogical supervision, and a supervisor was created and a conceptual explanation of the concept of pedagogical supervision in the context of the higher education study process was developed. The conceptual explanation of the concept of pedagogical supervision developed in the research reveals the possibilities of extended application of pedagogical supervision in the higher education study process, including both the components of pedagogical supervision and the essence of supervision as such – to provide support for the growth and improvement of the supervisee.
An Ideologized and a Realistic Discourse about Rural Latvian Teachers During the Stalinist Period: Analysis of the Content of the Newspaper “Skolotāju Avīze” and the Memoirs of Andrejs Dripe
Authors:   University of Latvia, Zelče Vita
Published: December 2022

This paper examines an ideologically idealised and a realistic discourse about rural Latvian teachers during the late 1940s and early 1950s, as represented, respectively, in the newspaper Skolotāju Avīze (The Teachers’ Newspaper), and in the memoirs of the former teacher and writer Andrejs Dripe. Dripe’s memoirs date back to the 1990s, when diaries written by him after WWII were published. The texts are analyzed with the discourse-historical approach, with the aim and result being the identification of discourse among and about rural teachers. The newspaper Skolotāju Avīze was established to create a discourse about the global excellence of Soviet teacher which, nonetheless, did include positive and negative evaluation. The basis of this judgement was the extent to which teachers did or did not include themselves in the Soviet educational system and in the processes of Sovietisation. Dripe also divided teachers into positive and negative categories in a discursive manner. His point of view, however, emerges from his and his family’s success in living and surviving in the Soviet system. The evidence suggests that discourse about teachers in such publications as Skolotāju Avīze and Dripe’ memoirs cannot be identified or analysed without the contextual foundations of history, in this case the Stalinist period in Latvia.
The Understanding of Academic Integrity in Primary Schools
Authors:   University of Latvia, Kaļķe Baiba , Balandīna Beāte , Kovaļevska Linda
Published: December 2022

Integrity has always been projected as a positive value. Academic integrity is one of the key aspects of the teaching/learning process, which is connected to the principles of ethics in addition to being genuine, honest and reliable. This is the basis for sustainable knowledge as well as a prerequisite for success. The study has been developed with the aim of assessing the understanding of learners and teachers in relation to academic integrity and exploring types of academic dishonesty and the factors affecting it during the primary education stage in Latvia. The study has explored concepts of academic integrity, dishonesty in theoretical literature and binding normative documents in Latvia, as well as the factors influencing them, and the correlation with ages and character features, and forms of academic dishonesty have been discussed. The type of research design is a case study, so the results of the study are not generalizable. The empirical part is based on the survey; the participants were teachers working in the primary education stage (157) and 345 students of Grades 4–9. The results obtained show that students and teachers do not have a shared understanding about the concept of academic integrity and its importance because no common guidelines have been developed for promoting academic integrity. The data also reveal that one quarter of teachers and more than half of the surveyed students have never encountered the issue of academic integrity in their experience. The main types of academic dishonesty mentioned are verbal communication, looking at someone else’s work; the main reasons noted are the lack of knowledge and skills, not enough time spent for preparing for a test and desire to obtain a good mark.
Teacher’s Role and Attitude During Socratic Conversations for Moral Education at High School
Authors:   University of Latvia, Keiša Patrīcija M. , Fernández González Manuel J.
Published: December 2022

It is important to address moral education in the context of human freedom, authenticity, and self-inquiry. Following the developmental needs of adolescents and young adults, moral education at high school should provide a social environment to address authentic identity search and inquiry upon existential questions by facilitating reflection about students’ own life experiences together with peers. A conceptual model of Socratic conversation as a method for moral education in high school was elaborated by the authors. This research addresses the role and attitude of a teacher in the practical implementation of such model. To explore the opinions of educational actors, a Socratic conversation intervention (four high school students and a researcher-facilitator), expert interviews (a teacher and a youth psychotherapist) and focus group discussion (five young adults working with youth) were organized in spring 2022 in Latvia. The results point to the fact that, for leading Socratic conversations, teachers should act as facilitators who have a personal interest in the topic and method, and who simultaneously allow space for the students to form and express their own opinions before revealing the teacher’s own views in the discussion. This can be an even more demanding job than a traditional teacher’s role, requiring teachers to tolerate a higher degree of uncertainty. Thus, teachers need adequate support, which could include first experiencing a Socratic conversation as participants beforehand. This research provides a significant contribution for understanding teachers’ role during Socratic conversations with high school students, and points to ways of supporting teachers using this method to the benefit of both students and teachers.
Projection Mapping Method in Advertising Design
Authors:   Rezekne Academy of Technologies, Katkeviča Santa , Strode Aina
Published: December 2022

Projection mapping is a projection technique used in video or interactive installations to project on irregularly shaped objects, adapting to their unique structure. The projection mapping technique dates back to the late 1960s, where it was mostly used for special film effects and film studio amusement parks. This technique was academically recognized in 1990 by the Office of the Future research experiment. Since then, projection mapping techniques have gained popularity and thus available programs have been created. Over the last decade, it has become extremely widespread around the world, especially in technologically advanced countries, with a tendency to advertise a product in a large format. This is a promising technology that can have a major impact on non-computer technology or design industries. Such as museums, libraries, universities, and various historical sites that want to get modern opportunities to present their specifics, services, and many other informative aspects. In this way, the public is offered to get acquainted with the offers in an attractive and interactive way. The aim of the article is to determine the evaluation criteria of the developed digital products by studying the essence of the projection mapping method, its use in advertising design. Research methods: theoretical – research and analysis of literature and Internet resources; empirical – expert interviews, analysis of analogues. Within the framework of the research, the following evaluation criteria were developed for the evaluation of projection mapping installations: Adequacy of the used method; Uniqueness of the content; Adequacy of the use of the programs; Cyclicality; Location of the projection. The criteria can be used by professionals as well as anyone interested in developing an original digital installation design.
Sustainability of Equestrian Physical Activities During Covid-19 Pandemic
Authors:   Latvian Academy of Sport Education, Ropa Anastasija
Published: December 2022

Covid-19 and restrictions intended to curb the pandemic have affected all areas of human life, but in particular physical activities and exercise habits. Reduction in the time devoted to physical activities have been reported in all demographic groups in various countries, leading to both physical (excessive weight, deterioration of posture, decreased eyesight, increased blood pressure, etc.) and psychological problems (depressive mood). Equestrians were less susceptible to certain restrictions because they could exercise outdoors and individually. Also, horse owners are more likely to regularly spend time with their equine sporting partners. It remains to be determined if and to what extent the pandemic has affected the physical activities of equestrians and whether equestrian physical activities provide a sustainable source of exercise during Covid-19 pandemic. In order to determine this, empirical evidence was collected using a questionnaire that was distributed among the multinational base population of equestrians. The working hypothesis is that patterns of physical activity while working with horses and taking care of the animals had to be adjusted due to restrictions, but overall equestrian activities were sustained and, in some cases, might have even increased. At the same time, the nature of activities is more likely to have been changed: for instance, privileging individual outdoor trainings over group indoor ones and non-competitive recreational riding over competitive activities.
Cinematic methods of scenario construction in the design of landscape parks
Authors: Troshkina Olena , Us Victoriia , Mostovenko Aleksandr , Shevchenko Luidmyla , Novoselchuk Natalia
Published: December 2022

The article describes and analyzes the possibility of using the method of writing a cinematic script in the design of park space, and it is a test of the method for teaching park design by the method of screenplay and generalization of the results. The authors analyze the possibility of applying this method in the actual design of the existing architectural environment of the city and compare the results with the results of their colleagues from another educational institution of architectural profile in performing similar tasks. The article proves that the cinematographic script, not the theatrical one, is the most suitable for the analysis of the architectural environment and writing the script of its perception. Sid Field's film paradigm, based on Sid Field's film paradigm, is based on the slogan "Every moment the spectator should be interested in what will happen next?" modern city life. According to the screenplay, which has its own structural units, the territory of the park is also divided into several functional zones, each of which corresponds to the cinematic elements. As in the movie, each part of the park evokes certain emotions, which are programmed by the designers in advance. This can be done by manipulating space and its boundaries. The authors suggest that this method of cinematic scenario can be used in the design of the architectural environment of the city, as a new part of it (urban quarter, neighborhood, and district) and in adjusting the existing historical environment.
High-Fat Diet–Induced DeSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice
Authors: Wang Sujuan , Yang Meichan , Li Pei , Sit Julian , Wong Audrey , Rodrigues Kyle , Lank Daniel , Zhang Deqiang , Zhang Kezhong , Yin Lei , Tong Xin
Published: December 2022

Dysregulated lipid droplet accumulation has been identified as one of the main contributors to liver steatosis during nonalcoholic fatty liver disease (NAFLD). However, the underlying molecular mechanisms for excessive lipid droplet formation in the liver remain largely unknown. In the current study, hepatic E4 promoter–binding protein 4 (E4BP4) plays a critical role in promoting lipid droplet formation and liver steatosis in a high-fat diet (HFD)–induced NAFLD mouse model. Hepatic E4bp4 deficiency (E4bp4-LKO) protects mice from HFD-induced liver steatosis independently of obesity and insulin resistance. Our microarray study showed a markedly reduced expression of lipid droplet binding genes, such as Fsp27, in the liver of E4bp4-LKO mice. E4BP4 is both necessary and sufficient to activate Fsp27 expression and lipid droplet formation in primary mouse hepatocytes. Overexpression of Fsp27 increased lipid droplets and triglycerides in E4bp4-LKO primary mouse hepatocytes and restored hepatic steatosis in HFD-fed E4bp4-LKO mice. Mechanistically, E4BP4 enhances the transactivation of Fsp27 by CREBH in hepatocytes. Furthermore, E4BP4 is modified by SUMOylation, and HFD feeding induces deSUMOylation of hepatic E4BP4. SUMOylation of five lysine residues of E4BP4 is critical for the downregulation of Fsp27 and lipid droplets by cAMP signaling in hepatocytes. Taken together, this study revealed that E4BP4 drives liver steatosis in HFD-fed mice through its regulation of lipid droplet binding proteins. Our study also highlights the critical role of deSUMOylation of hepatic E4BP4 in promoting NAFLD.
Association of sodium-glucose cotransporter-2 inhibitors with time to dementia: a population-based cohort study
Authors: Wu Che-Yuan , Iskander Carina , Wang Christa , Xiong Lisa Y. , Shah Baiju R. , Edwards Jodi D. , Kapral Moira K. , Herrmann Nathan , Lanctôt Krista L. , Masellis Mario , Swartz Richard H. , Cogo-Moreira Hugo , MacIntosh Bradley J. , Rabin Jennifer S. , Black Sandra E. , Saskin Refik , Swardfager Walter
Published: December 2022

  

Objective

Type 2 diabetes increases dementia risk, but clear evidence to recommend interventions that can mitigate that risk remains lacking. This population-based retrospective cohort study aimed to determine whether new use of sodium-glucose cotransporter-2 (SGLT2) inhibitors compared to dipeptidyl peptidase-4 (DPP4) inhibitors was associated with lower dementia risk.

Research Design and Methods 

Ontario residents aged ≥66 years who were new users of an SGLT2 inhibitor or a DPP4 inhibitor from July 1st, 2016 to March 31st, 2021 entered the cohort. Incident dementia was identified using a validated algorithm for Alzheimer’s disease and related dementias. Propensity-score weighted Cox proportional hazards models were used to obtain adjusted hazard ratios (aHR) and confidence intervals (CI) for time to incident dementia. To address reverse causality and disease latency, the observation window started at 1-year lag-time from cohort entry. The primary analysis followed intention-to-treat exposure definition, and a secondary as-treated analysis was performed.

Results 

Among 106,903 individuals, SGLT2 inhibitors compared with DPP4 inhibitors were associated with lower risk of dementia (14.2/1000 person-years; aHR [95% CI]=0.80 [0.71-0.89]) over a mean follow-up of 2.80 years from cohort entry. When stratified by different SGLT2 inhibitors, dapagliflozin exhibited the lowest risk (aHR [95% CI]=0.67 [0.53-0.84]), followed by empagliflozin (aHR [95% CI]=0.78 [0.69-0.89]), whereas canagliflozin showed no association (aHR [95% CI]=0.96 [0.80-1.16]). The as-treated analysis observed a larger association (aHR [95% CI]=0.66 [0.57-0.76]) than the intention-to-treat analysis.

Conclusions 

SGLT2 inhibitors showed an association with lower dementia risk in older people with type 2 diabetes. Randomized controlled trials are warranted. 
A Look at Socialism in the Official Acts of the Roman Catholic and Orthodox Russian Church at the Turn of the 19th — 20th Centuries: Comparative Analysis
Authors: Ivan V. Ambartsumov
Published: December 2022

The article compares the assessments of socialist ideology in the official documents of the Roman Catholic and Russian Orthodox churches in the late 19th — early 20th centuries. As a reflection of the Catholic position, the encyclicals of the Roman popes are considered, first, the encyclical “Rerum Novarum”, published by Leo XIII in 1891. The author considers the program of the course “denunciation of socialism” approved by the Holy Synod in seminaries. A comparison of these documents shows that both churches condemned socialism as an atheistic doctrine and considered it a dangerous utopia. Leo XIII, in “Rerum Novarum”, denounced basic socialist doctrines such as the socialization of private property and class struggle, but at the same time acknowledged the seriousness of the problems of capitalist society and the plight of the workers. The pope opposed the socialist utopias with the Catholic social doctrine, which provided for the active participation of the church in social life, state regulation of relations between labor and capital, and the development of a peaceful labor movement. The Russian Orthodox Church during the period under review was unable to develop its own social doctrine as an alternative to socialism. In the program of the anti-socialist course for Orthodox seminaries, the materialistic and anti-Christian nature of socialism was proved, and Marxism was subjected to detailed analysis and criticism. At the same time, there was no such harsh criticism of the flaws of capitalism on the part of the Russian hierarchy. Such one-sidedness made the position of the Russian Orthodox Church in the fight against socialism much weaker than the position of the Roman Catholic Church.
Neutrophil and monocyte extracellular traps in the diagnosis of post-COVID syndrome
Authors: Salmasi JM , Poryadin GV , Panina MI , Larina VN , Ryzhikh AA , Stodelova EA , Kazimirskii AN
Published: December 2022

Post-COVID syndrome (long covid, post COVID-19 condition) is characterized by cognitive and mental disorders, chest and joint pain, impaired sense of smell and taste, as well as by gastrointestinal and cardiac disorders. The diagnosis of post-COVID syndrome is based mainly on the patients' complaints. To date, no optimal diagnostic method has been proposed. The study was aimed to compare the informative value of the indicators obtained during conventional assessment of patients with post-COVID syndrome and the blood levels of neutrophil (NETs) and monocyte (METs) extracellular traps. The study involved neutropils and monocytes collected from 21 patients with post-COVID syndrome aged 18–59. Fluorescence microscopy and the SYBR Green (Evrogen) fluorescent dye for double-stranded DNA were used for enumeration and imaging of extracellular traps. Clinical and laboratory indicators make it impossible to identify the changes specific for post-COVID syndrome. At the same time, post-COVID syndrome is characterized by inflammation in the vascular endothelium. The filamentous forms of NETs found in blood are a laboratory feature of such aseptic inflammation. The filamentous forms of NETs have been detected only in those patients who have a history of mild to severe СOVID-19, while the filamentous forms of METs have been found in patients having a history of severe infection. The findings show that the detection of the filamentous forms of NETs and METs in blood is the most informative diagnostic feature of post-COVID syndrome.
Las fuentes orales como patrimonio intangible de la Guerra Civil
Authors: Rodríguez López Sofía
Published: December 2022

Este artículo trata sobre las fuentes orales como recurso para la investigación sobre la guerra civil española. En primer lugar, se refiere a su naturaleza social como resultado de la memoria histórica y la memoria colectiva. Después recuerda su introducción en la historiografía internacional, recorriendo los principales archivos y repositorios de dominio público para el acceso a estos testimonios. Finalmente, pasa al ejemplo práctico de cómo utilizar esas entrevistas para el análisis de la sociedad de los años treinta, fijándose en una serie de conceptos identitarios e interseccionales como los de clase, género, confesión religiosa, vecindad o militancia política.
Sustained utilisation of skill set: assessing ex-agripreneurial trainees of agricultural school programme in Osun State, Nigeria
Authors: Oyebode Lukman Abiodun , Adeloye Kolawole Adelekan , Longe Peace Obehi
Published: December 2022

Charitable organisations complement government efforts in training young Nigerians in sustainable agricultural practices. A potent means of assessing the effectiveness of this training outlet/effort is the assessment of the sustained utilisation of the skill set acquired by its ex-agripreneurial trainees. A multistage sampling procedure was used to capture sample subjects. The last five sets of ex-trainees were purposively and proportionately sampled, this gave a sample size of 97. Both quantitative and qualitative data were elicited from the sample subjects. The majority (74.2 %) of the ex-trainees were male, middle-aged (38 years), made a net average monthly income of ₦ 46,618, and had an appreciable length of experience (11 years) as agripreneurs. The results of this study were as follows: training on the skill set received by the ex-agripreneural trainees was effective (75.3 %). Inadequate finance (x̅= 3.0), economic instability (x̅= 2.40) and poor state of infrastructure (x̅ = 2.23) were prominent among constraints associated with sustained utilisation of the skill set acquired. Enthusiasm about my enterprise (x̅= 1.72) was the attribute of an agripreneur possessed most. Sustained utilisation of skill set was high (61.9 %). A significant relationship was established between household size (r = 0,456), net average monthly income (r = 0.537), years of experience as an agripreneur (r = 0.509), perceived effectiveness of training received (r = 0.380), attributes of an entrepreneur possessed (r = 0.380), and sustained utilisation of skill set acquired. The study recommends that the training modules/templates are sustained and adapted by other training outlets/efforts owing to their effectiveness and the sustainability potentials it confers.
Semen characteristics and fertility response of crosses between white and black plumage indigenous turkeys under artificial insemination
Authors: Olubisi Ewuola Emmanuel , Isiaq Olarinre , Okiki Adagba , Tope Abioye , Oluwaseun Adeyemi , Samson Fabule
Published: December 2022

Semen quality and fertility in crossbreeding between white plumage and black plumage indigenous turkey hens using artificial insemination were investigated. Eighty-two healthy indigenous turkeys, comprising 72 hens (Thirty-two black and forty white) and 10 toms (five black and five white) were used. The turkeys were grouped into four treatments based on the breeding plans: T1 (White toms X White hens), T2 (Black toms X Black hens), T3 (White toms X black hens) and T4 (Black toms X White hens). Semen was harvested from white toms, pooled, and inseminated at 0.02ml into hens in T1 and T3. Semen harvested from black toms were also pooled and inseminated at same dose into hens in T2 and T4. White tom semen quality parameters were 97%, 91%, 96%, and 532×106 cells/mL for mass activity, motility, livability, and sperm concentration, respectively. Black tom semen quality parameters were 91%, 93%, 95%, and 293×106 cells/mL for mass activity, motility, livability, and sperm concentration, respectively. Egg fertility were 99.63% in T1, 99.81% (T2), 99.84%(T3), and 99.27% (T4). Hatchability in T1, T2, T3, and T4 were 57.67%, 72.54%, 67.65%, and 64.82%, respectively. Besides sperm concentration, semen quality parameters and fertility in indigenous turkey were not affected by plumage colour