bluuebunny/crossref_metadata_2025 huggingface dataset:
Восстановительный ремонт изготавливаемых из пкм обводообразующих панелей с низкоэнергетическими ударными повреждениями
Authors:   Центральный аэрогидродинамический институт им. проф. Н.Е. Жуковского, Жуковский, Россия, Вермель В.Д. , Титов С.А. ,   Центральный аэрогидродинамический институт им. проф. Н.Е. Жуковского, Жуковский, Россия, Ковалев И.Е. ,   Центральный аэрогидродинамический институт им. проф. Н.Е. Жуковского, Жуковский, Россия, Качарава И.Н. ,   Центральный аэрогидродинамический институт им. проф. Н.Е. Жуковского, Жуковский, Россия, Никуленко А.А. ,   Центральный аэрогидродинамический институт им. проф. Н.Е. Жуковского, Жуковский, Россия
Published: October 2023

Рассмотрены наиболее известные способы ремонта изготавливаемых из полимерных композиционных материалов обводообразующих панелей конструкции самолетов малой авиации, получивших низкоэнергетические ударные повреждения (до 35÷70 Дж). В их числе: установка усиливающей накладки с механическим или клеемеханическим соединением, вклеивание вставки из слоев угле- или стеклоткани с финишным прессованием, а также разработанный оперативный способ ремонта, с использованием раздвижных металлических вставок, ориентированный на проведение в аэродромных условиях. Получены результаты расчетно-экспериментальных исследований остаточной прочности после ремонта, включая испытания методических и конструктивно-подобных образцов. С использованием метода конечных элементов и линейной модели деградации свойств композитного монослоя, в программном комплексе «ABAQUS» смоделировано закритическое поведение панелей, отремонтированных установкой металлических накладок с болтовыми крепежными элементами, как при наличии, так и при отсутствии клея в соединении. Показано, что предельная нагрузка на панель с клееболтовым соединением выше, чем при болтовом соединении без клея. Расчетные результаты подтверждены тензометрическими измерениями на ремонтной накладке, установленной на повреждение. Выполнено расчетное обоснование выбора конструктивных параметров рассматриваемых способов ремонта из условия восстановления прочностных характеристик отремонтированных деталей. Результаты экспериментальных исследований на образцах подтвердили ожидаемые оценки предварительных расчетов по восстановлению остаточной прочности после выполнения ремонта.
Учет влияния вида напряженного состояния в рамках объединенной модели фазово-структурного деформирования сплавов с памятью формы с изотропным упрочнением
Authors:   ФГБУН Институт прикладной механики РАН, Москва, Россия, Мовчан А.А.
Published: October 2023

Вариант объединенной модели фазово-структурного деформирования сплавов с памятью формы (СПФ), учитывающий для структурного механизма деформирования только изотропное упрочнение с интегральным параметром, распространен на случай учета влияния вида напряженного состояния не только на процессы деформирования, как по фазовому, так и по структурному механизму, но и на сам процесс фазового перехода. Для учета этого влияния используется параметр вида девиатора напряжений, пропорциональный отношению третьего инварианта девиатора напряжений к кубу интенсивности напряжений. При моделировании фазового механизма деформирования для процесса прямого термоупругого превращения учитываются как процесс образования зародышей мартенсита, так и процесс их развития. При моделировании обратного термоупругого фазового превращения учитывается только процесс деградации мартенситных мезоэлементов до нулевого значения их объема. Сформулированы в явном виде выражения для приращений фазово-структурных деформаций, в том числе и для процессов, происходящих с изменением вида напряженного состояния. Установлено положение об активных процессах пропорционального нагружения. Найдены условия, при выполнении которых определяющие уравнения объединенной модели в приращениях могут быть проинтегрированы до решения краевой задачи, что приводит к конечным соотношениям между напряжениями и фазово-структурными деформациями, и существенно упрощает решения краевых задач. Представлена дифференциальная форма определяющего соотношения для параметра фазового состава - объемной доли мартенситной фазы, пригодная для описаний прямых и обратных термоупругих фазовых переходов, как в полных, так и в неполных циклах и учитывающая влияние на этот процесс изменений вида напряженного состояния.
PENGEMBANGAN INSTRUMEN DAN EVALUASI PEMAHAMAN PRODUK BAGI DIVISI PENJUALAN MENGGUNAKAN QUIZIZZ PADA PT. ACTiV
Authors: Wijaksono Bahtera Alam , Fazrie Mohammad , Parulian Dudi
Published: October 2023

The development of the industrial revolution 4.0 make technology is improvement, because of that make so many things activities all fields become very simple,  especially in companies engaged in the IT sector. Seeing these conditions need to upgrade the capabilities of new and old personnel, specifically for the sales force. By seeing this the team became very interested making an activity that could improve the quality and performance of the personnel by providing evaluation and training, which is expected in the future to be able to help in carrying out their duties. This community service aims to be able to provide good utilization for the company in the future. The team will use Quizizz an e-learning media delivery because attractive and interactive and for the research method used the Quasi Experimental Design. For the evaluating of a product and for the medium purposive sampling we are using documentation, observasion, pretest and posttest, for data used in making these questions category volume, profitability, product and other relevant measures. The final results from material carried out by the team the results quite 85% - 95% in very good category. The conclusion from this study is that e-learning using Quizizz is very effective in improving the ability, which previously got enough marks very good at the assessment and Quizizz can be used as a data bank, which can be used continuously as a media e-learning for other staff at PT. Alfa Cipta Technology Virtual (ACTiV).
Exploring Type 2 Inflammation in Chronic Obstructive Pulmonary Disease
Authors: Liao Deborah
Published: October 2023

This symposium took place during the 2023 meeting of the European Respiratory Society (ERS), with a focus on targeting chronic obstructive pulmonary disease (COPD) with Type 2 inflammation, and the emerging biologic landscape. The speakers discussed the clinical consequences of COPD through an understanding of pathological changes, the spectrum of inflammatory pathways, the role of Type 2 inflammation in the pathophysiology of COPD, and the evolving clinical landscape in COPD. Klaus Rabe, Full Member (Chair), LungenClinic, Grosshansdorf, Germany, utilised hypothetical clinical scenarios to contextualise the clinical presentation of COPD as a consequence of disease pathology, specifically chronic inflammation leading to structural changes of airways and parenchymal destruction resulting in airflow limitation, leading to worsening symptoms, and increasing further exacerbation risk. Stephanie Christenson, Assistant Professor of pulmonology at the University of California, San Francisco, USA, followed with a discussion of the heterogeneity of inflammatory pathways, exploration of distinct inflammatory cells and cytokines, and the evolving state of the knowledge of the diverse inflammatory pathways associated with COPD. COPD inflammation can be differentiated by distinct inflammatory cells and cytokines into Type 1/Type 3 inflammation (i.e., neutrophilic inflammation) and Type 2 inflammation. However, there is potential overlap in the various inflammatory mechanisms driving COPD via the alarmins IL-33 and thymic stromal lymphopoietin. In addition, the key cytokines IL-4, IL-13, and IL-5 mediate the pathophysiology of COPD with Type 2 inflammation. Altogether, the heterogeneous inflammatory pathways contribute to characteristic features of COPD, fibrosis (small airways), wall thickening, airway remodelling, and clinical features, such as shortness of breath at rest. Dave Singh, Professor of respiratory pharmacology at The University of Manchester, UK, then discussed active areas of investigation in the development of additional treatments for patients with COPD.
Five Segments of the Right Upper Lobe Bronchus on Bronchoscopic Anatomy: A Rare Case Report and Review of Literature
Authors: Sharma Priya , Rai Deependra Kumar , Kumar Manohar , Gupta Vatsal Bhushan
Published: October 2023

The authors present a case of a 77-year-old female, a former smoker with a history of chronic obstructive pulmonary disease who underwent bronchoscopy for evaluation of haemoptysis. The bronchoscopy revealed an anatomical variant of the right upper lobe bronchus with five branches instead of the usual three. This case report describes a peculiar anatomical abnormality in the right upper lobe. A review of the literature related to various variants in bronchial anatomy is presented.

Conclusion: Awareness of this anatomical variation provides valuable information to clinicians, particularly thoracic surgeons, to plan surgical interventions, tailor procedures, and minimise complications.
BİREYSEL BAŞVURU YOLUNDA TEMELLENDİRİL(E)MEMİŞ ŞİKÂYET
Authors: ERDEM Burak
Published: October 2023

Bireysel başvuru kapsamında gerçekleştirilen şikâyetlerde temel hak ve özgürlük ihlali iddiasının somutlaştırılmaması veya ihlal iddiasına dayanak teşkil eden bilgi, belge ve delillerin yargısal mercilere ibraz edilmemesi, temellendirilmemiş şikâyet sonucunu doğurmaktadır. Kasten ya da ihmalkâr davranışlar neticesinde ihlal iddialarını temellendirmede yetersiz kalan başvuranlar, açıkça dayanaktan yoksunluk kararlarıyla karşı karşıya kalmaktadır. Bununla beraber, görünürde temellendirilmemiş şikâyete vücut veren hâllerin tümü, başvuranlara kusur atfedilebilecek sebeplerden ileri gelmemektedir. Gerçekten de kimi durumlarda, hukuka aykırı muamele ve davranışlar vasıtasıyla kamusal makamlar, temellendirilmiş başvuru yapılmasına mâni olmaktadır. Bu gibi hâllerde yargısal merciler ekseriyetle, kabul edilmezlik kararı vermekten kaçınmakta; kamu otoritelerinin hukuka aykırı davranışlarının sonuçlarının bireylere yükletilmemesi gerektiği düşüncesi, başvuru dosyalarının karara bağlanmasında ön plana çıkmaktadır. Keza, temellendirilmemiş şikâyetlerden farklı olarak başvuranların kusurlu davranışlarından söz etmeye imkân bulunmayan temellendirilememiş şikâyet hâlleri, kamusal makamların hukuka aykırı davranışlarıyla sınırlı kalmamakta; psikolojik taciz, işkence ve kötü muamele benzeri temellendirilmeye objektif açıdan elverişsiz durumlar söz konusu olduğunda da bu kavram, benzer gerekçelerle gündeme gelebilmektedir.
CUMHURİYET KARŞITI BİR KURUM: CUMHURBAŞKANI YARDIMCILIĞI
Authors: DOĞAN Oğuz Kaan
Published: October 2023

Cumhurbaşkanı yardımcısı, yürütmenin monist şekli olan başkanlık rejimine has bir makamdır. İlk kez ABD Anayasası ile düzenlenen cumhurbaşkanı yardımcılığı, Latin Amerika başta olmak üzere başkanlık rejimini kabul eden ülkelerde çeşitli değişikliklerle birlikte korunan bir makam olmuştur. Cumhuriyetçilik geleneği, yaklaşık iki bin beş yüz yıllık geleneğinde yasaya dayalı özyönetimi ilke edinmiştir. Modern cumhuriyetlerin kurulması ile yürütme organının seçimle işbaşına gelmesi cumhuriyetin dar ve geniş tanımlarının ayrılmaz bir ilkesi olmuştur. Türkiye’de 2017 yılında yapılan anayasa değişikliği ile getirilen yeni sistemde cumhurbaşkanı yürütmenin tek organı olarak yerini almıştır. Cumhurbaşkanının yanında yeni bir makam olarak cumhurbaşkanı yardımcısı da anayasal bir kurum haline gelmiştir. Cumhurbaşkanınca atanması, cumhurbaşkanına vekalet etmesi, sorumluluğunun sadece cumhurbaşkanına karşı olması, işleyeceği suçlara ilişkin geniş bir dokunulmazlığa sahip olan cumhurbaşkanı yardımcısının anayasal konumu doktrinde tartışmalıdır. cumhuriyetçiliğin geleneksel ilkeleri ile Türk anayasa mevzuatı ve Anayasa Mahkemesinin cumhuriyet kavramına ilişkin içtihatları göz önüne alındığında cumhurbaşkanı yardımcısına ilişkin Anayasanın 106. Maddesinin, Anayasanın 1, 2 ve 4. maddelerinde düzenlenen cumhuriyet ilkesine aykırı bir düzenleme olduğu sonucuna ulaşılmıştır.
TANIMA KURALININ AHLÂKİ İÇERİĞİ SORUNU: H.L.A. HART VE JOSEPH RAZ ARASINDAKİ “MUTLAK” ANLAŞMAZLIKH
Authors: KOÇAKGÖL Muhammet
Published: October 2023

Tanıma kuralının ahlaki içeriği problemi hukuki pozitivizm içerisinde birçok bağlamda tartışılan bir konudur. Hukuki pozitivizmin önde gelen iki temsilcisi H.L.A. Hart ve Joseph Raz’ın bu konu hakkındaki görüşleri ise farklılık göstermekte ve bu nedenle önem arz etmektedir. Hart, tanıma kuralının ahlakilik kriteri içermesinin mümkün olabileceğini düşünürken, Raz bunun mümkün olmadığını iddia etmektedir. Bu bağlamda iki düşünür arasında keskin bir ayrışma olduğu düşünülebilmektedir. Makalede bu ayrışmanın göründüğü kadar büyük ya da mutlak bir anlaşmazlık olmadığı ortaya konulmaya çalışılmıştır. Bu kapsamda Hart’ın tanıma kuralına yönelik görüşleri ve Raz’ın bu görüşlere yönelik itirazlarına yer verilmiş, devamında bu farklılıkların mutlak bir anlaşmazlık olup olmadığı ortaya konulmaya çalışılmıştır. Bu yapılırken düşünürlerin kavramsal analiz yolunu seçmeleri ve hukuki muhakeme konusunda farklı düşünmeleri üzerinde durulmuştur. Sonuç bölümünde iki düşünürün kavramsal analiz yolunu seçmeleri ve hukuki muhakemeyi “hukuk nedir” sorusuna dahil edip etmemekten kaynaklı ayrışmaları göz önüne alındığında, tanıma kuralının ahlaki içeriğiyle ilgili mutlak bir anlaşmazlığa sahip olmadıkları iddia edilmiştir.
Disorders of mental health in children and adolescents with hematological malignancies
Authors: Kravchenko N. E. , Suetina O. A. , Sachuk O. V. , Valiev T. T.
Published: October 2023

Introduction. The success in pediatric oncohematological disorders treatment cause increasing scrutiny not only to remission achievement and long-term patient survival, but also to supportive dysfunctions, which go with malignancy and anti-tumor treatment. Blood tumors cause all organs and systems disorders, and psychic dysfunctions of these are not in the last place.

Aim. To characterize mental health and psychic disorders types in children and adolescents with oncohematological diseases during hospital stay.

Materials and methods. It was analyzed mental health of 169 children and adolescents with hemoblastoses, who were treated at Pediatric Oncology and Hematology Research Institute of National Research Cancer Centre n. a. N. N. Blokhin (Moscow, Russia) in 2022 year. 50 (29.6 %) patients needed a psychiatric consultation. Among oncohematological disorders acute lymphoblastic leukemia was predominated – 25 (50 %), lymphomas – 17 (34 %) and acute myeloid leukemia – 8 (16 %) patients. Mental health data assessed after examination/consultation of clinical psychologist and psychiatrist.

Results. Asthenia was found in all 50 (100 %) patients, who were recommended a psychiatrist consultation, in 47 (94 %) – adjustment disorder, in 15 (30 %) – vexatious and neurotic disorder, in 16 (32 %) – affective syndromes, less often (18 and 14 % respectively) – behavioral deviations and eating disorders. As single cases in 2 (4 %) patients an intellectual disability and in 1 (2 %) a psychotic syndrome were diagnosed. As a role the most pronounced psychopathological conditions were upon admission to the hospital and decreased during the treatment and adaptation.

Conclusions. One third of children and adolescents, hospitalizing to oncohematological clinic need a psychiatrist consultation. Multidisciplinary care for such patients with pediatric oncologist, psychiatrist and clinical psychologist can cure psychogenic disorder effectively, improving the stay of patient at the hospital and best compliance between the doctor and patient.
Depleting Cellular Retinoic Acid Binding Protein 1 Impairs UPRmt
Authors: Wei Chin-Wen , Lerdall Thomas , Najjar Fatimah , Wei Li-Na
Published: October 2023

Mitochondrial dysfunction underlines neurodegenerative diseases which are mostly characterized by progressive degeneration of neurons. We previously reported that Cellular retinoic acid Binding protein 1 (Crabp1) knockout (CKO) mice spontaneously developed age-dependent motor degeneration, with defects accumulated in spinal motor neurons (MNs), the only cell type in spinal cord that expresses CRABP1. Here we uncovered that mitochondrial DNA (mtDNA) content and the expression of genes involved in respiration were significantly reduced in CKO mouse spinal cord, accompanied by significantly elevated reactive oxygen species (ROS) and unfolded protein load, indicating that CRABP1 deficiency caused mitochondrial dysfunction. Further analyses of spinal cord tissues revealed significant reduction in the expression and activity of superoxide dismutase 2 (SOD2), as well as defected mitochondrial unfolded protein response (UPRmt) pathway, specifically an increase in ATF5 mRNA but not its protein level, which suggested failure in the translational response of ATF5 in CKO. Consistently, eukaryotic initiation factor-2α, (eIF2α) phosphorylation was reduced in CKO spinal cord. In a CRABP1 knockdown MN1 model, siCrabp1-MN1, we validated the cell-autonomous function of CRABP1 in modulating the execution of UPRmt. This study reveals a new functional role for CRABP1 in the execution of mitochondrial stress response, that CRABP1 modulates eIF2α phosphorylation thereby contributing to ATF5 translational response that is needed to mitigate mitochondria stress.
Management of business processes of commercial enterprises under the conditions of marital state in Ukraine
Authors:   National Aviation University, SKIBITSKA Liana
Published: October 2023

The article defines the peculiarities of managing business processes of trade enterprises in the conditions of martial law. The author focuses on the World Bank study “Adversity and Adaptation: How Ukrainian Private Firms Survive During the Russian Invasion” and on the monthly study conducted by the Association of Retailers of Ukraine using an online survey among hundreds of owners and CEOs of enterprises across the country, the results of which indicate a very limited number of closed commercial facilities and shops, according to which only 3% of companies were closed with the beginning of the full-scale invasion of the Russian Federation in Ukraine, while 97% continued their activities. A SWOT analysis was conducted for the business process management strategy of trading enterprises. The article outlines the main problems faced by trade enterprises in wartime conditions, among which the main ones are: a decrease in demand for goods and services, which in turn led to a reduction in sales volumes and a decrease in the profits of trade enterprises; a change in market conditions, a change in the competitive environment, fluctuations in the exchange rate, an increase in the cost of production and supply - all this affects the efficiency and profitability of the enterprise; security and supply risk, restrictions on the movement of goods, reduction in the quality of logistics services; significant outflow of buyers of goods in many regions of Ukraine; outflow of personnel due to mobilization, evacuation abroad, migration to western regions; decrease in purchasing power of consumers, etc. Based on the results of the research, proposals were developed regarding measures and an algorithm of actions to overcome the problems faced by trading enterprises, in particular: establishing clear goals and strategies for the business process of a trading enterprise; assessment of the current state of the business process; definition of key performance indicators (KPIs); development of a business process optimization plan, establishment of specific measures and steps to be taken to achieve set goals; implementation of planned activities and making changes in the business process, in particular in the organizational structure, procedures, technologies, communication, etc.; monitoring and control of implementation of planned changes, measurement and analysis of results, verification of achievement of goals; constant improvement of business process management based on innovative technologies.
Diagnostics and identification of anomalous zones of trunk pipelines at underwater crossings using digital elevation model
Authors:   Saint-Petersburg State Mining University, Mustafin M. G. , Pavlov N. S. ,   Saint-Petersburg State Mining University, Valkov V. A. ,   Saint-Petersburg State Mining University, Vasiliev B. Yu. ,   Saint-Petersburg State Mining University
Published: October 2023

The article considers the issues of geodetic support for monitoring the technical condition of main gas pipelines underwater crossings (MGPUC). The purpose of the research is to increase the accuracy of determining the depth of the gas pipeline underwater crossings of main gas pipelines by taking into account the zones of faulty location of the pipeline (anomalous zones) and the bottom surface above MGPUC. The main problem of determining the technical condition of the gas pipeline underwater crossing is the difficulty of determining the depth of the gas pipeline due to the influence of external factors (soil, constructions and communications) on the measuring equipment (underwater trace detectors). The study indicates the accuracy of building digital elevation models (DEM) of the bottom, from which the calculation of the protective roll over the gas pipeline, which affects the determination of the technical state, and the causes of anomalous zones, as well as the ways of their determination. The variants of increasing the accuracy of calculating the depths of the gas pipeline location taking into account the DEM data are studied. The approach to definition of the method of spatial interpolation for construction of the bottom DEM according to the echolocation data depending on the surface curvature changes is offered. The authors note the interrelation of determining the criterion of technical condition of under-water crossing with the accuracy of DEM construction and determination of the spatial position of the pipeline. The proposed approaches are aimed at reducing the influence of the systematic part of the error and increasing the accuracy of the depth of occurrence, which is an urgent task.
Using space images for calibration linear referencing system for geospatial pipeline simulation
Authors:   Innopolis University, Barinova K. G. , Dolgopolov D. V. ,   CJSC "Ay Co", Melkiy V. A. ,   Institute of Marine Geology and Geophysics, Far Eastern Branch Russian Academy of Sciences, Verkhoturov A. A. ,   Institute of Marine Geology and Geophysics, Far Eastern Branch Russian Academy of Sciences
Published: October 2023

The technique of geospatial modeling of pipeline systems, which is discussed in the article, is designed to use satellite survey data for calibration of a linear referencing system (LRS). It is proposed to use satellite images to determine the planned position of pipeline objects, which can act as calibration points. The article considers the features of using space images to determine the planned position of pipeline objects that can act as calibration points are considered. The technique of geospatial modeling of pipeline systems based on the use of LRS is based on the data of in-line inspections (ILI) in the formation and updating of geospatial models of pipeline systems. The use of such a technique makes it possible to independently detect pipeline defects by means of ILI and perform their localization in the geoinformation space with the help of LRS. The use of space-based images to increase the calibration points of the LRS makes it possible to significantly increase the accuracy of the position of defects in space. The novelty of the work lies in the refinement of the geopositioning of pipeline infrastructure objects by using linear coordinate systems in conjunction with space images, which was not proposed in previously published papers on this topic.
Calculating the parameters of terrestrial laser scanning of industrial object
Authors:   Emperor Alexander I St. Petersburg State Transport University, Sharafutdinova A. A. ,   Trimetari Consulting LLC, Bryn M. Ja. ,   Emperor Alexander I St. Petersburg State Transport University
Published: October 2023

Terrestrial laser scanning of industrial facilities has a number of features, among which are: a large number of laser scanner installation stations, short distances between stations, complex geometry and differences in the reflectivity of the measurement objects materials, as well as a large amount of data derived from the work. To achieve the required accuracy in solving different tasks these features must be taken into account when performing measurements, as well as when processing measurement results. Based on the analysis early research and practical experience, authors propose a generalized technological scheme for terrestrial laser scanning of industrial facilities. In the article the scan settings also calculated, including setting of scan resolution, the choice of the distance to the object and the permissible beam incidence angle. Proposals are also given for the point cloud registration and datum transformation using an Iterative Closest Point Algorithm. The performed studies can be useful for precalculating the accuracy of the terrestrial laser scanning results.
Oil spill monitoring using Sentinel-2B remote sensing data
Authors:   Siberian State University of Geosystems and Technologies, Zulin K. A. , Kulik E. N. ,   Siberian State University of Geosystems and Technologies
Published: October 2023

The article provides a comparative analysis of the results of calculating vegetation indices based on remote sensing data from various survey systems in order to determine the suitability of using Sentinel-2B satellite images to assess the degree of damage to natural components affected by oil spills. As the main criteria for assessing the informative capacity of remote sensing data, their spectral and spatial resolution are considered. The results of experimental studies characterizing the spatial distribution of the values of the NDVI and SAVI vegetation indices in the oil spill area are presented, on the basis of which the advantages and disadvantages of the Landsat and PlanetScope survey systems are determined when monitoring the state of open soils, including those contaminated with oil products. In order to increase the reliability of the results of the study, it is proposed to use modifications of the considered vegetation indices.
Morphometric analysis of the watershed of the Serligkhem river (Tuva) using GIS ahd ERS
Authors:   Tuvinian Institute for Exploration of Natural Resources of Siberian Branch of the Russian Academy of Science, Chupikova S. A. , Prudnikov S. G. ,   Tuvinian Institute for Exploration of Natural Resources of Siberian Branch of the Russian Academy of Science, Chuldum A. F. ,   Tuvinian Institute for Exploration of Natural Resources of Siberian Branch of the Russian Academy of Science
Published: October 2023

The Geographic Information System (GIS) serves as an effective tool for determining the structure of the catchment area, water resources management and planning. An important aspect of watershed characteristics is quantitative analysis performed using geoinformation technologies. In this study, GIS and fractal geometry methods were used to identify morphological features and analyze the properties of the Serlig-Khem River basin (Todzhinsky district), Republic of Tyva. The analysis of morphometric parameters includes both linear and areal aspects of the basin. The area of the studied catchment basin, determined in the GIS environment, is 3032.79 km2, mainly with a tree-like asymmetric type of river network pattern. The average bifurcation coefficient of 3.13 indicates that the basin is largely controlled by the structure. The density of the river network is 0.34 km/km2, the basin is pear-shaped. The territory under study has a predominantly mountainous character, with a slope of up to 40-30 degrees within the Academician Obruchev ridge and on the meridional segment. The fractal analysis carried out in the work confirms the assumption about the relationship between the value of the fractal dimension indicator and the degree of coverage of the catchment area by the lines of the river network.
Risk-based model of nature management in the conditions of the Dolinsky reserve of the Sakhalin region
Authors:   Sakhalin State University, Abramova S. V. , Boyarov E. N. ,   Sakhalin State University, Kuptsova O. V. ,   Sakhalin State University, Dvoinova N. F. ,   Sakhalin State University
Published: October 2023

On the territory of the Russian Federation there are more than 13 thousand specially protected natural areas (hereinafter referred to as SPNAs). In general, within the boundaries of these protected areas, the economic use of lands is prohibited or significantly limited, which is mainly due to their special status associated with the need to preserve and reproduce endangered species of flora and fauna and their habitats. Permitted types of activities and nature management in the Dolinsky State Natural Complex Reserve of Regional Importance (hereinafter referred to as the Dolinsky Reserve) are associated with the need to implement territorial infrastructure projects for the oil and gas complex of the Sakhalin Region, namely, the construction and maintenance of linear structures of the transport infrastructure. At the same time, the peculiarities of the geographical location of the Sakhalin Region, the peculiarities of the geological, geomorphological structure, climatic and other features of the region, for the safe implementation of permitted types of nature management in this territory, require taking into account existing and potential risk-forming factors that can be realized in the form of hazards and threats to natural and man-made nature. This necessitates risk-based modeling based on the identification of risk-generated parameters on the territory of protected areas and the use of the entire available information array to calculate the possible risks of hazardous and emergency situations in the study area. In the course of the study, based on the materials of satellite images Landsat-8, Sentinel-2A, SRTM data, as well as the analysis of statistical data on seismic activity, fire hazard, flood conditions, and technogenic load of the study area, an assessment was made of the state of the Dolinsky reserve territory (Sakhalin Island). As a result, sufficient information content of the source materials was revealed, a risk-based risk assessment model was developed, the results of the data processing and calculation methodology were demonstrated, and a risk map of environmental management in the conditionsof the Dolinsky reserve was compiled.
Investigation of the parameters of MEMS deflectors to determine the magnetic permeability of the dipole material
Authors:   Siberian State University of Geosystems and Technologies, Korneyev V. S. , Shergin S. L. ,   Siberian State University of Geosystems and Technologies
Published: October 2023

Micro-electromechanical (MEMS) deflectors with electromagnetic control and an experimental stand for measuring their functional parameters are considered. The electromagnetic control method makes it possible to obtain a high positioning accuracy of the reflected beam along one spatial coordinate, and also provides increased speed with the time of deviation of the light flux to a predetermined position of 5–10 μs. Graphs of experimental and theoretical dependences of the angle of deviation of the light flux on the induction of the control magnetic field of MEMS deflectors are presented. Using the method of successive approximations, the value of the magnetic permeability of the dipole material µ = 120 was selected, and the maximum value of the angular deviation of the light flux along one spatial coordinate was determined, which is 13.50. The MEMS presented in this paper can be used, first of all, as high-speed deflectors and optical flow scanners with a beam diameter of up to 2.5 mm.
Fragments of the history of the Optical Faculty and the Institute of Optics NIIGAiK-SGGA-SGUGiT: organizational, technical and scientific aspects
Authors:   Siberian State University of Geosystems and Technologies, Petrov P. V. , Ushakov O. K. ,   Siberian State University of Geosystems and Technologies, Shaburova A. V. ,   Siberian State University of Geosystems and Technologies
Published: October 2023

The historic material, characterizing the main content of the Optical Faculty and the Institute of Optics development as part of NIIGAiK–SGGA–SGUGiT, discovers the organizational, technical and scientific features of each period of development of this structural unit. The background, content, staffing and results are shown. The article contains specific information official publications and eye-witness accounts.
History of development of Physical Culture Department
Authors:   Siberian State University of Geosystems and Technologies, Stukalo L. M.
Published: October 2023

The article considers the work of Physical Culture Department from its foundation till nowadays. It shows sports achievements mainly in box, acrobatics, ski race, ping pong. The role of physical culture and mass work is noted, the high level of organization of which, including with the participation of foreign students from universities - partners of NIIGAiK–SSGA–SSUGT, was associated with the pas-sage of summer practices for students of 1–3 courses at the university training ground near the village of Izdrevaya.
The use of unmanned aerial vehicles in the farms of the subtaiga zone of Western Siberia
Authors:   Tara branch of the Omsk State Agrarian University named after P. A. Stolypin, Bankrutenko A. V. , Eliseeva N. S. ,   Tara branch of the Omsk State Agrarian University named after P. A. Stolypin
Published: October 2023

Currently, agriculture in the world, including Russia, is turning into one of the clearest examples of the rapid and successful introduction of new technologies, and these include the use of unmanned aerial vehicles (UAV), so we set a goal to study the use of UAVs in the farms of the agroindustrial complex in the conditions of the subtaiga zone of Western Siberia, in particular in the farms of the Tarsky municipal district of the Omsk region. The article presents studies that were carried out for the first time in the Omsk region. The feature of the research is the use of a quadcopter to monitor agricultural land in a highly wooded area (65-70%). As a result of the work, all the tasks were completed, the positive and negative sides of the use of drones in the farms of the subtaiga of the Omsk region were revealed. We believe that our practical experience in the use of UAVs in agriculture will be useful for relevant managers and specialists.
Advances in the research of exosomes in renal cell carcinoma: from mechanisms to applications
Authors: Rui Rui , Zhou Liqun , He Shiming
Published: October 2023

Renal cell carcinoma (RCC) is one of the most malignant urological tumors. Currently, there is a lack of molecular markers for early diagnosis of RCC. The 5-year survival rate for early-stage RCC is generally favorable; however, the prognosis takes a significant downturn when the tumor progresses to distant metastasis. Therefore, the identification of molecular markers for RCC is crucial in enhancing early diagnosis rates. Exosomes are a type of extracellular vesicle (EV) typically ranging in size from 30 nm to 150 nm, which contain RNA, DNA, proteins, lipids, etc. They can impact neighboring receptor cells through the autocrine or paracrine pathway, influence cellular communication, and regulate the local immune cells, consequently shaping the tumor immune microenvironment and closely associating with tumor development. The clinical application of exosomes as tumor markers and therapeutic targets has ignited significant interest within the research community. This review aims to provide a comprehensive summary of the advancements in exosome research within the context of RCC.
Real-time video analysis allows the identification of large vessel occlusion in patients with suspected stroke: feasibility trial of a “telestroke” pathway in Northwestern Switzerland
Authors: Thilemann Sebastian , Traenka Christoph Kenan , Schaub Fabian , Nussbaum Lukas , Bonati Leo , Peters Nils , Fladt Joachim , Nickel Christian , Hunziker Patrick , Luethy Marc , Schädelin Sabine , Ernst Axel , Engelter Stefan , De Marchis Gian Marco , Lyrer Philippe
Published: October 2023

Background and aim

Loss of time is a major obstacle to efficient stroke treatment. Our telestroke path intends to optimize prehospital triage using a video link connecting ambulance personnel and a stroke physician. The objectives were as follows: (1) To identify patients suffering a stroke and (2) in particular large vessel occlusion (LVO) strokes as candidates for endovascular treatment. We have chosen the Rapid Arterial Occlusion Evaluation (RACE) scale for this purpose.

Methods

This analysis aimed to verify the feasibility of prehospital stroke identification by video assessment. In this prospective telestroke cohort study, we included 97 subjects, in which the RACE score (items: facial palsy, arm and leg motor function, head and gaze deviation, and aphasia or agnosia) was applied, and the assessment videotaped by a trained member of the Emergency Medical Services (EMS) in the field using a mobile device. Each recorded patient video was independently assessed by three experienced stroke physicians from a certified stroke center and compared to the neuroimaging gold standard. Within this feasibility study, the stroke code was not altered by the outcome of the RACE assessment, and all patients underwent the standard procedures within the emergency unit.

Results

We analyzed 97 patients (median age 78 years, 53% women), of whom 51 (52.6%) suffered an acute stroke, 12 (23.5%) of which were due to an LVO and 46 patients had symptoms mimicking a stroke. The sensitivity of stroke identification was 77.8%, and specificity was 53.6%. In regard to the identification of an LVO, sensitivity was 69.4% and specificity was 84.3%. The inter-rater agreement in the RACE-score assessment was ICC = 0.82 (intraclass-correlation coefficient).

Conclusion

These results confirm our hypothesis that the local telestroke concept is feasible. It allows correct (i) stroke and (ii) LVO identification in the majority of the cases and thus has the potential to assist in efficient prehospital triage.
Implementing stroke care in a lower-middle-income country: results and recommendations based on an implementation study within the Nepal Stroke Project
Authors: Tunkl Christine , Paudel Raju , Bajaj Sunanjay , Thapa Lekhjung , Tunkl Patrick , Chandra Avinash , Shah Bhupendra , Karmacharya Balgopal , Subedi Ashim , Jalan Pankaj , Ghimire Pradesh , Ghimire Mahesh Raj , Dorje Gampo , Begli Nima Haji , Golenia Jessica , Gajurel Bikram Prasad , Shreyan Shirsho , Sharma Nooma , Krauss Alexandra , Pandian Jeyaraj , Fischer Thomas , van der Merwe Jan , Wick Wolfgang , Hacke Werner , Gumbinger Christoph
Published: October 2023

Background

Globally, the majority of strokes affect people residing in lower- and lower-middle-income countries (LMICs), but translating evidence-based knowledge into clinical practice in regions with limited healthcare resources remains challenging. As an LMIC in South Asia, stroke care has remained a healthcare problem previously unaddressed at a national scale in Nepal. The Nepal Stroke Project (NSP) aims to improve acute stroke care in the tertiary healthcare sector of Nepal. We hereby describe the methods applied and analyze the barriers and facilitators of the NSP after 18 months.

Methods

The NSP follows a four-tier strategy: (1) quality improvement by training healthcare professionals in tertiary care centers; (2) implementation of in-hospital stroke surveillance and quality monitoring system; (3) raising public awareness of strokes; and (4) collaborating with political stakeholders to facilitate public funding for stroke care. We performed a qualitative, iterative analysis of observational data to analyze the output indicators and identify best practices.

Results

Both offline and online initiatives were undertaken to address quality improvement and public awareness. More than 1,000 healthcare professionals across nine tertiary care hospitals attended 26 stroke-related workshops conducted by Nepalese and international stroke experts. Monthly webinars were organized, and chat groups were made for better networking and cross-institutional case sharing. Social media-based public awareness campaigns reached more than 3 million individuals. Moreover, live events and other mass media campaigns were instituted. For quality monitoring, the Registry of Stroke Care Quality (RES-Q) was introduced. Collaboration with stakeholders (both national and international) has been initiated.

Discussion

We identified six actions that may support the development of tertiary care centers into essential stroke centers in a resource-limited setting. We believe that our experiences will contribute to the body of knowledge on translating evidence into practice in LMICs, although the impact of our results must be verified with process indicators of stroke care.
Acute low back pain as infusion-related reaction to monoclonal antibodies
Authors: Majenka Pawel , Loquai Carmen , Schöning Tilman , Enk Alexander , Hassel Jessica
Published: October 2023

Monoclonal antibodies, such as PD-1 inhibitors, are increasingly used in various cancers. Acute low back pain as infusion-related reaction (IRR) to monoclonal antibodies is poorly described. We report a bicentric series of 10 cases of acute low back pain due to administration of monoclonal antibodies directed against PD-1/PD-L1 for skin cancer treatment in patients treated at University Hospital Heidelberg and University Medical Center Mainz (Germany). The management of IRR symptoms was immediate interruption of infusion and analgesia leading to quick improvement and complete symptom relief in all patients. Our findings suggest that the risk of developing low back pain as IRR is depending on the concentration of the administered drug. Low back pain as IRR can be managed by early interruption of infusion and by decreasing the infusion rate or concentration in following administrations.
Is there a role for traditional and complementary medicines in managing chronic fatigue? a systematic review of randomized controlled trials
Authors: Li Yuxiao , Yang Jingya , Chau Chi Ian , Shi Junnan , Chen Xianwen , Hu Hao , Ung Carolina Oi Lam
Published: October 2023

Introduction: Chronic fatigue syndrome (CFS) is an increasingly common condition that is challenging to treat due to unclear etiology and a lack of consensus on clinical diagnosis and treatment guidance. Many affected people resorted to using traditional and complementary medicines (T&CMs). However, the evidence for T&CMs for CFS has been inconclusive and continues to evolve. The study aims to identify, summarize and assess the most recent evidence on the efficacy and safety of T&CMs for CFS.

Methods: Randomized controlled trials (RCTs) investigating T&CMs for CFS published in English of Chinese between 1 January 2013 and 31 December 2022 were searched from 7 databases. RCTs comparing T&CMs with no treatment, placebo, or pharmacological medicine were included, irrespective of language or blinding. The Consolidated Standards of Reporting Trials Statement extensions for Chinese herbal medicine Formulas (CONSORT-CHM) and the Cochrane Collaboration’s Risk of Bias tool were used to evaluate the quality and risk of bias of included studies.

Results: A total of 62 RCTs investigating 43 types of T&CMs and involving 5,231 participants with CFS were included in this review. The primary outcome measures mainly included the scoring of fatigue symptoms using the validated tool Fatigue Scale-14 (FS-14) or the TCM syndrome score. The main interventions showing overall efficacy were Chaihu Guizhi Decoction and Buzhong Yiqi combined with Xiao Chaihu Decoction, and 148 ingredients were identified, including Astragali Radix, Glycyrrhizae Radix et Rhizoma, Atractylodis Macrocephalae Rhizoma, and Bupleuri Radix. The most significant effect was the improvement of fatigue, followed by TCM-diagnosed symptoms and other psychological conditions. No serious adverse effect had been reported. However, the quality of the RCTs included RCTs were found to be suboptimal, and the risk of bias remained uncertain.

Conclusion: Some evidence from RCTs supported the efficacy and safety of T&CM in CFS. However, given the methodological and quality heterogenicity of the included studies, the recommendations of T&CMs in treating CFS remain inconclusive. To develop better quality evidence about T&CMs for CFS, future studies should employ more objective diagnosis standards and outcome measurements, larger sample size, and better bias control, and ensure the compliance with the corresponding reporting guidelines.

Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022362268, identifier CRD42022362268.
Phytoplankton in headwater streams: spatiotemporal patterns and underlying mechanisms
Authors: Zeng Chenjun , Xing Ran , Huang Bensheng , Cheng Xiangju , Shi Wenqing , Liu Shufeng
Published: October 2023

Phytoplankton are key members of river ecosystems wherein they influence and regulate the health of the local environment. Headwater streams are subject to minimal human activity and serve as the sources of rivers, generally exhibiting minimal pollution and strong hydrodynamic forces. To date, the characteristics of phytoplankton communities in headwater streams have remained poorly understood. This study aims to address this knowledge gap by comparing phytoplankton communities in headwater streams with those in plain rivers. The results demonstrated that within similar watershed sizes, lower levels of spatiotemporal variability were observed with respect to phytoplankton community as compared to plain rivers. Lower nutrient levels and strong hydrodynamics contribute to phytoplankton growth limitation in these streams, thereby reducing the levels of spatiotemporal variation. However, these conditions additionally contribute to greater phytoplankton diversity and consequent succession towards Cyanophyta. Overall, these results provide new insights into the dynamics of headwater stream ecosystems and support efforts for their ecological conservation.
The Effect of Plant Growth-Promoting Rhizobacteria on Soil Properties and the Physiological and Anatomical Characteristics of Wheat under Water-Deficit Stress Conditions
Authors: Alaskar Abdulaziz A. , AL-Shwaiman Hind A.
Published: October 2023

This study aimed to evaluate the effects of plant growth-promoting Rhizobacteria (PGPR) treatments, B1, Azosprillium lipoferum Sp2 and B2, A. lipoferum Sp2 + Pseudomonas sp. SARS12, as well as inorganic nitrogen doses (60, 100, 140 and 180 kg N ha–1) on some soil physical characters, physiological, anatomical and yield parameters as well as nitrogen use efficiency (NUE) of wheat under water deficit stress. Results showed that water stress significantly decreased physiological characters such as chlorophyll content (6.7 and 9.8%) and relative water content (13.7 and 11.2%) in both seasons, respectively. Nevertheless, proline and malondialdehyde (MDA) were increased significantly (26.9, 12.3% and 90.2, 96.4%) in both seasons, respectively, as signals for water stress. The anatomical characteristics of flag leaves were negatively affected. Inoculation of wheat grains with PGPR significantly increased field capacity and RWC, adjusted enzymes’ activity and thus improved the physiological and yield traits and NUE as well as improving the anatomical features of flag leaves. Moreover, the combination of integrated PGPR and 140 kg N ha−1 significantly improved grain yield and its components as well as grain N uptake in comparison to control treatments. In conclusion, PGPR improved wheat productivity and NUE; they are an eco-friendly and cost-effective approach for improving plant production, and reducing nutrient leaching hazards and the negative impact of water stress.