bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of viewing digital environment images on college students’ positive emotions, nature relatedness, and environmental preference
Authors: Ning Ping , DeWitt Dorothy , Chin Hai Leng , Wang Han
Published: January 2025

Purpose

This study aims to investigate the impact of viewing different types of digital environment images on college students’ positive emotions, nature relatedness and environmental preference. This aimed to address the gap in empirical studies regarding the effects of digital environment images on these psychological constructs.

Design/methodology/approach

This study used a three-group experimental between-subjects design. Participants (48 undergraduate students) were divided into three groups, each viewing a different set of digital images (nature, city or object). Pre- and posttest measures assessed positive emotions and nature relatedness, whereas environmental preference was measured after image viewing. One-way analysis of variance and post hoc Tukey’s honestly significant difference (HSD) tests were used to analyze the data.

Findings

Viewing digital nature images elicited significantly higher positive emotions, nature relatedness and environmental preference compared to viewing city or object images. In addition, environmental preference for the digital object group was marginally higher than the city group.

Research limitations/implications

This study was limited by its relatively small sample size. Although further research is needed to investigate the underlying mechanisms behind the observed effects, this study provides valuable implications for education, economic dimensions and public policy initiatives, encouraging the development of pro-environmental attitudes and behaviors.

Practical implications

The findings suggest that incorporating digital nature images into learning activities can promote positive emotions, nature relatedness and environmental preference among college students. This has implications for the design of digital learning environments, especially for those with limited access to natural environments.

Social implications

By promoting positive emotions and nature relatedness, digital nature experiences can contribute to emotional well-being and potentially foster pro-environmental behaviors. This can have implications for promoting sustainable lifestyles and environmental conservation efforts.

Originality/value

This study provides original empirical evidence on the impact of viewing digital environment images on several psychological constructs. It highlights the potential of digital nature experiences as a complement to direct nature exposure, particularly for those with limited access to natural environments. These findings contribute to the growing body of literature on the benefits of digital nature experiences and have implications for various fields, including education, environmental psychology and human–computer interaction.
Better Outcomes for Ovarian Cancer Associated With the Detection of Anti‐EBV TCR CDR3s: Potential Relevance to Diffuse Large B‐Cell Lymphoma
Authors: Goel Nandini , Baker Madeline C. , Aboujaoude Michael T. , Diaz Michael J. , Jain Rahul , Huda Taha I. , Chobrutskiy Andrea , Chobrutskiy Boris I. , Song Joanna J. , Vangala Veda Naga Priya , Blanck George
Published: January 2025

Objectives

Given the ongoing challenges regarding the specific roles of viral infections in cancer etiology, or as cancer co‐morbidities, this study assessed potential associations between anti‐viral, T‐cell receptor (TCR) complementarity domain region‐3 (CDR3s), and clinical outcomes for ovarian cancer.

Methods

TCR CDR3s were isolated from ovarian cancer specimens for a determination of which patients had anti‐viral CDR3s and whether those patients had better or worse outcomes.

Results

Analyses revealed that patients with exact matches of anti‐Epstein–Barr virus (EBV) CDR3 amino acid sequences exhibited better outcomes for both overall and disease‐specific survival. However, better outcomes were not observed when assessing anti‐viral CDR3s representing cytomegalovirus, influenza A, or Sars‐CoV‐2. Due to previous occurrences of the occasional misdiagnoses of lymphoma as ovarian cancer, the frequency of anti‐EBV CDR3s in lymphoma patients was determined. These frequencies were relatively high, particularly for diffuse large B‐cell lymphoma.

Conclusions

These findings (i) underscore the potential value of anti‐EBV immune responses in terms of patient outcomes; (ii) raise questions about the potential value of anti‐EBV immunotherapies; and (iii) support further inquiry into the relationship between EBV infection and previously reported cases of ovary‐resident lymphoma.
CAR T access and outcomes in large B‐cell lymphoma according to ethnicity and socioeconomic deprivation in the UK
Authors: Dragoi Diana , Cusworth Samuel , Oldham Laura , Sanderson Robin , Norman Jane , Chandan Joht Singh , Mathew Amrith , Kumar Emil , Paneesha Shankara , Tholouli Eleni , Moya Davila Andres , Bouziana Styliani , Patten Piers , Hardefeldt Prudence , Yallop Deborah , Chaganti Sridhar , Burns David , Kuhnl Andrea
Published: January 2025

Data on the impact of ethnic and socioeconomic factors on Chimeric antigen receptor (CAR) T‐cell therapy (access and outcomes are limited, but key to understand whether results from the registration trials are generalizable to real‐world patient populations. Here, we analysed ethnicity, socioeconomic deprivation and referral patterns in a cohort of 314 large B‐cell lymphoma patients approved for third‐line CD19 CAR‐T across three large UK CAR‐T centres. Patients from deprived areas had a lower infusion rate compared to low deprivation areas (73% vs. 86%, p = 0.04). CAR‐T response rates, toxicities, progression‐free survival or non‐relapse mortality were similar with respect to ethnicity or deprivation. We did not find evidence of referral barriers according to ethnicity, but potential regional barriers for socioeconomically deprived patients in two of three centres. Intention‐to‐treat overall survival was significantly inferior in patients from deprived areas (1‐year OS 44.5% vs. 58% for high vs. low deprivation; p = 0.02), likely reflecting general health disparities and higher drop‐out rates in this group. Our data suggest similar outcomes of CD19 CAR‐T‐treated patients across a socioeconomically and ethnically heterogeneous real‐world population. Results demonstrate broad access to CAR‐T within the UK national delivery system, but the high drop‐out rate and potential regional referral barriers for deprived communities should be further investigated.
Anaerobic Adhesive Effect on the Counter‐Torque of Zirconia Implant Abutment Screws: In Vitro Study
Authors: Nascimento Lara Rúbia Marques , da Silva Resende Camila , Sá Ana Flor , Francescato Olívia , Dias Danilo Rocha , Lages Frederico Santos
Published: January 2025

Introduction

Implantology has become a primary solution for tooth loss due to excellent osseointegration and high long‐term success rates. However, complications such as abutment screw loosening, especially in implant‐supported single crowns, compromise prosthesis longevity. Anaerobic adhesives (AAs) have shown promise in mechanical fields for preventing screw loosening, but their effectiveness in dental implants, particularly zirconia, remains uncertain. This study evaluates the effect of medium‐strength AA on the counter‐torque and screw stability of zirconia implant abutments.

Methods

Twenty neodent Zi zirconia implants were divided into two groups: control (n = 10) without adhesive and experimental (n = 10) using medium‐strength AA (Loctite 242) on the prosthetic screw. Abutment screws were torqued to 32 Ncm and underwent mechanical cycling simulating mastication. Counter‐torque was measured post‐cycling. Structural damage and adhesive residues were inspected using a stereomicroscope. Data were analyzed using descriptive statistics including means and standard deviations (SDs). The Shapiro–Wilk test was performed to assess data normality. The counter‐torque values after cycling were compared to the installation torque value using the one‐sample t‐test. Comparison between groups was performed using Student's t test. Statistical significance was established as p < 0.05.

Results

The presence of AA was detected on all screws, without causing damage and was easily removable. Both groups showed significantly lower counter‐torque values than the installation torque, with no significant intergroup difference.

Conclusion

Medium‐strength AA did not significantly affect the counter‐torque values of zirconia implant abutment screws, although it was easily removable and caused no damage.
CYP2C19 Genotype‐Guided Antiplatelet Therapy and Clinical Outcomes in Patients Undergoing a Neurointerventional Procedure
Authors: Tunehag Kayla R. , Pearce Ashton F. , Fox Layna P. , Stouffer George A. , Solander Sten , Lee Craig R.
Published: January 2025

In neurovascular settings, including treatment and prevention of ischemic stroke and prevention of thromboembolic complications after percutaneous neurointerventional procedures, dual antiplatelet therapy with a P2Y12 inhibitor and aspirin is the standard of care. Clopidogrel remains the most commonly prescribed P2Y12 inhibitor for neurovascular indications. However, patients carrying CYP2C19 no‐function alleles have diminished capacity for inhibition of platelet reactivity due to reduced formation of clopidogrel's active metabolite. In patients with cardiovascular disease undergoing a percutaneous coronary intervention, CYP2C19 no‐function allele carriers treated with clopidogrel experience a higher risk of major adverse cardiovascular outcomes, and multiple large prospective outcomes studies have shown an improvement in clinical outcomes when antiplatelet therapy selection was guided by CYP2C19 genotype. Similarly, accumulating evidence has associated CYP2C19 no‐function alleles with poor clinical outcomes in clopidogrel‐treated patients in neurovascular settings. However, the utility of implementing a genotype‐guided antiplatelet therapy selection strategy in the setting of neurovascular disease and the clinical outcomes evidence in neurointerventional procedures remains unclear. In this review, we will (1) summarize existing evidence and guideline recommendations related to CYP2C19 genotype‐guided antiplatelet therapy in the setting of neurovascular disease, (2) evaluate and synthesize the existing evidence on the relationship of clinical outcomes to CYP2C19 genotype and clopidogrel treatment in patients undergoing a percutaneous neurointerventional procedure, and (3) identify knowledge gaps and discuss future research directions.
Born this way and stuck in the middle: The queer child at the center of parental conflict1
Authors: Davis Lindsey Sank , Currie Nathaniel
Published: January 2025

While there is significant extant literature on lesbian, gay, bisexual, transgender, queer, and other sexual orientation and gender minority (LGBTQ+) parents and a large and growing body of research on the mental health of LGBTQ+ youth, there remains a dearth of empirical literature focused on the experiences of LGBTQ+ youth facing parental conflict, separation, and divorce. This unfortunate trend is telling as to the perceived legitimacy of LGBTQ+ identities in children and adolescents and highlights critical gaps in need of amelioration. This paper reviews and applies interdisciplinary research on LGBTQ+ youth and families, addressing complex questions raised by two de‐identified cases involving the navigation of co‐parenting conflicts surrounding a bisexual adolescent and a transgender adolescent. The literature review highlights the heightened mental health risks LGBTQ+ youth experience due to minority stress and familial rejection. The wider sociopolitical and legal contexts affecting LGBTQ+ youth and their families, including the harmful effects of anti‐LGBTQ+ legislation, are also addressed. Family court professionals are advised to take a careful multi‐perspective approach to cases involving LGBTQ+ youth and to engage in advocacy and educational efforts in their respective fields to foster inclusive and supportive psycholegal environments for LGBTQ+ families in the United States and worldwide.
Effectiveness of behavioural and psychological interventions for managing obesity in children and adolescents: A systematic review and meta‐analysis framed using minimal important difference estimates based on GRADE guidance to inform a clinical practice guideline
Authors: Henderson M. , Moore S. A. , Harnois‐Leblanc S. , Johnston B. C. , Fitzpatrick‐Lewis D. , Usman A. M. , Sherifali D. , Merdad R. , Rigsby A. M. , Esmaeilinezhad Z. , Morrison K. M. , Hamilton J. , Ball G. D. C. , Birken C. S. ,   the Steering Committee for Updating Canada's Clinical Practice Guideline for Managing Pediatric Obesity
Published: January 2025

Objective

Conduct a systematic review and meta‐analysis of randomized controlled trials (RCTs) of behavioural and psychological interventions for managing paediatric obesity.

Methods

Eligible studies, published between 1985 and 2022, included 0 to 18 year olds with outcomes reported ≥3 months post‐baseline, including patient‐reported outcome measures (PROMs), cardiometabolic and anthropometric outcomes, and adverse events (AEs). We pooled data using a random effects model and assessed certainty of evidence (CoE) related to minimally important difference estimates for outcomes using GRADE.

Results

We included 73 unique RCTs (n = 6305 participants, 53% female). Intervention types included physical activity (n = 1437), nutrition (n = 447), psychological (n = 1336), technology‐based (n = 901) or multicomponent (≥2 intervention types, n = 2184). Physical activity had a small effect on health‐related quality of life (HRQoL), varying effects ranging from moderate to very large on blood pressure, lipids and insulin resistance, and a small effect on BMIz. Nutrition had a small effect on lipids, insulin resistance and BMIz. Psychological interventions showed a small effect on HRQoL and triglycerides and moderate benefits on depressive symptoms, while technology interventions showed small benefits on blood pressure and BMIz. Multicomponent interventions had a large benefit on anxiety, small benefit on depressive symptoms, with large to very large benefits on lipids, and small benefits for diastolic blood pressure, insulin resistance and BMIz. AEs were reported infrequently, and when reported, were described as mild.

Conclusion

Physical activity and multicomponent interventions showed improvements in PROMs, cardiometabolic and anthropometric outcomes. Future trials should consistently measure PROMs, evaluate outcomes beyond the intervention period, and study children <6 years of age.
Long‐term follow‐up of the impact of brief sleep and lifestyle interventions in infancy on BMIz‐score at 11 years of age: The POI randomized controlled trial
Authors: Taylor Rachael W. , Galland Barbara C. , Heath Anne‐Louise M. , Gray Andrew R. , Meredith‐Jones Kim A. , Fortune Sarah A. , Sullivan Trudy A. , Adebowale Taiwo , McIntosh Deborah , Jackson Rosie F. , Taylor Barry J.
Published: January 2025

Objective

To determine whether BMI differences observed at 5 years of age, from early intervention in infancy, remained apparent at 11 years.

Methods

Participants (n = 734) from the original randomized controlled trial (n = 802) underwent measures of body mass index (BMI), body composition (DXA), sleep and physical activity (24‐h accelerometry, questionnaire), diet (repeated 24‐h recalls), screen time (daily diaries), wellbeing (CHU‐9D, WHO‐5), and family functioning (McMaster FAD) around their 11th birthday. Following multiple imputation, regression models explored the effects of two interventions (‘Sleep’ vs. ‘Food, Activity and Breastfeeding’ [FAB]) using a 2 × 2 factorial design.

Results

Five hundred twelve children (48% female, mean [SD] age 11.1 [0.1] years) returned for the 11‐year assessment (63% of original sample). Significant differences in BMI z‐score (mean difference; 95% CI: −0.16; −0.41, 0.08) or the risk of overweight (including obesity) (odds ratio; 95% CI: 0.85; 0.56, 1.29) were no longer observed between children who had received the sleep intervention compared with those who had not. By contrast, children who had received the FAB intervention had greater BMI z‐scores (0.24; 0.01, 0.47) and a higher risk of obesity (1.56; 1.03, 2.36) than children not enrolled in FAB. No significant differences were observed in any lifestyle variables nor wellbeing measures across all groups.

Conclusions

Sustained reductions in BMI and obesity risk from an early sleep intervention were not apparent 9 years later, whereas a more traditional lifestyle intervention resulted in increased rates of obesity, not explained by any differences in lifestyle behaviours measured.

Clinical Trial Registry

ClinicalTrials.gov number NCT00892983, https://clinicaltrials.gov/study/NCT00892983.
The Potential of Poetry in Mental Health Nurse Pre‐registration Education
Authors: Pearson Mark
Published: January 2025

This paper examines the potential of poetry as a resource within mental health nurse pre‐registration education. There has long been a debate as to whether the art or the science of nursing should be foregrounded within pre‐registration education, especially in the UK within recent years as the latest Nursing and Midwifery Council's standards of pre‐registration education appear to have shifted the focus towards the acquisition of skills, giving less consideration to the holistic transformatory process of education. The paper uses the conceptualisation of education by Beista, who proposes that education can be considered in relation to the three domains of qualification, socialisation and subjectification. Qualification refers to the acquisition of knowledge and skills, socialisation refers to the process of joining a professional group, and subjectification refers to the development of the individual as a reflective, thoughtful and responsible individual. The paper explores each of these domains in turn and considers how poetry can make a unique contribution in supporting both personal development, and the acquisition of professional knowledge and skills. The reading and writing of poetry can support students to challenge epistemic blinders, enhance their interpersonal skills and develop a more authentic professional identity.
The Second Round of a Population‐Based Seroprevalence Study of Anti–SARS‐CoV‐2 Antibodies and COVID‐19 Vaccination Assessment in the Republika Srpska, Bosnia and Herzegovina
Authors: Aćimović Jela , Mijović Biljana , Mašić Srđan , Petković Miroslav , Sladoje Dragana Puhalo , Knežević Darija , Dević Jelena Đaković , Spaić Dragan , Vladičić‐Mašić Jelena , Bokonjić Dejan , Palo Mirza , Vaughan Aisling , Pebody Richard , Nardone Anthony , Škrbić Ranko
Published: January 2025

Introduction

The aim of the study was to assess the seroprevalence of SARS‐CoV‐2 in the Republika Srpska, Bosnia and Herzegovina, after five waves of COVID‐19 and 1 year after introduction of vaccination to better understand the true extent of the COVID‐19 pandemic in the population of the Republika Srpska and role of vaccination in achieving herd immunity.

Methods

The population‐based study was conducted from December 2021 to February 2022 in a group of 4463 individuals in the Republika Srpska. Total anti–SARS‐CoV‐2 antibodies were determined in serum specimens using the Wantai total antibody ELISA assay. Quantitative analysis, using Kantaro IgG assays, was performed in subsamples (1273 specimens) to asses and compare levels of IgG among vaccinated, recovered and participants with hybrid immunity. To adjust for age and gender distribution in sample, poststratification method is applied.

Results

The overall cumulative seroprevalence was 94.6% (95% CI = 93.9–95.3). Significantly higher seroprevalence rates were observed among vaccinated 97.8% (95% CI = 97.3–98.4) comparing to unvaccinated participants (89.5%, 95% CI = 88.0–91.0). Seroprevalence increases with the number of received doses. Among various professions, the highest seroprevalence was found in the service industry (98.1%), education (98.0%) and healthcare (96.9%). We found that 2.2% of vaccinated and 3.6% of participants with SARS‐CoV‐2 positivity during 2021 had no detectable IgG antibodies. Both seroprevalence (98.6%) and antibody titres (1094.4 AU/mL) were significantly higher among people with hybrid immunity.

Conclusion

Our findings reveal a 2.3‐fold increase in seroprevalence of SARS‐CoV‐2 antibodies due to infection and vaccination, comparing to the first study performed 1 year earlier. This study provides better understanding of the SARS‐CoV‐2 transmission and highlights the important role of the vaccination in achieving the population immunity. Periodically conducted population‐based seroprevalence studies are important to understand temporal trends and assess surveillance system performance and public compliance with vaccination policies.
Atypical Atrial Flutter: Electrophysiological Characterization and Effective Catheter Ablation
Authors: Johner Nicolas , Namdar Mehdi , Shah Dipen C.
Published: January 2025

Atrial flutter (AFL), defined as macro‐re‐entrant atrial tachycardia, is associated with debilitating symptoms, stroke, heart failure, and increased mortality. AFL is classified into typical, or cavotricuspid isthmus (CTI)‐dependent, and atypical, or non‐CTI‐dependent. Atypical AFL is a heterogenous group of re‐entrant atrial tachycardias that most commonly occur in patients with prior heart surgery or catheter ablation. The ECG pattern is poorly predictive of circuit anatomy but may still provide mechanistic insight. AFL is difficult to manage medically and catheter ablation is the preferred treatment for most patients. Recent progress in technology and clinical electrophysiology has led to detailed characterization of re‐entry circuits and effective ablation strategies. Combined activation and entrainment mapping are key to identifying the re‐entry circuit. The presence of a slow‐conducting isthmus, localized re‐entry, dual‐loop re‐entry or bystander loops may lead to misleading activation maps but can be identified by electrogram examination and entrainment mapping. In the occasional patient without inducible AFL, substrate mapping in sinus rhythm may be a viable strategy. Long‐term ablation success requires the creation of a transmural continuous lesion across a critical component of the re‐entry circuit. Procedural endpoints include bidirectional conduction block across linear lesions and non‐inducibility of atrial tachycardia. The present review discusses the epidemiology, mechanisms, ECG characteristics, electrophysiological characterization, and catheter ablation of atypical AFL.
Effectiveness of a Knowledge Level of Hypertension on Blood Pressure Control, Treatment Adherence, and Physical Activity of Hypertensive Individuals
Authors: Gömleksiz Mehtap , Gömleksiz Muhammet Rıdvan , Gelen Şeyma , Uzala Emine Sena , Yakar Burkay
Published: January 2025

Individuals' knowledge and attitudes about hypertension are important in controlling blood pressure (BP) and reducing hypertension‐related mortality and morbidity. The current study aimed to investigate the effect of hypertension knowledge level on treatment adherence, BP control, and physical activity of hypertensive individuals. This prospective and cross‐sectional study was conducted in the Family Medicine clinic of a tertiary healthcare institution between October 2023 and April 2024. The study included 218 patients with essential hypertension. The BP of all patients was measured with a calibrated mercury sphygmomanometer, and the patients were divided into two groups: uncontrolled BP and controlled BP. The Hypertension Knowledge Level Scale (HK‐LS), General Practice Physical Activity Questionnaire (GPPAQ), and Modified Morisky Medication Adherence Scale (MMMAS‐6) were administered to all participants. Although 40.8% (n = 89) of the patients had their BP under control, 59.2% (n = 129) did not. The median weight of the participants whose BP was not under control was higher than those whose BP was under control (p < 0.05). A significant positive correlation was found between the hypertension knowledge score and the Morisky total score, Morisky motivation, and Morisky knowledge scores. There was a significant negative correlation between the GPPAQ score and both systolic and diastolic BP, as well as a significant positive correlation with hypertension knowledge levels. Assessing the knowledge level of hypertensive patients about their disease, recognizing their lifestyles, and questioning their habits is crucial for recommending individualized health interventions tailored to the needs and characteristics of this population.
Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in India
Authors: Alexander Thomas , Hiremath Jagdish S. , Swahney Jitendra P. S. , Chandra Subhash , Jain Peeyush , Chandra Praveen , Sinha Nakul , Sashikanth T. , Bachhu Yugandhar , Balachandran Anil , Jayagopal Pathiyil Balagopalan , Unni T. Govindan , Nair Tiny , Kannan Kumaresan , Prabhakar Dorairaj , Chenniappan M. , Mahajan Ajay U. , Karnik Rajiv D. , Ponde Chandrashekhar K. , Advani Prashant , Khan Idris Ahmed , Goyal Brij Mohan , Vaidyanathan P. R. , Prajapati Hiren , Verberk Willem J.
Published: January 2025

This study evaluated initial antihypertensive drug prescription patterns in Indian healthcare settings. An observational, cross‐sectional, prospective prescription registry analyzed prescriptions for 4723 newly diagnosed hypertension patients. Additionally, it investigated the extent to which physicians adhered to either European or Indian hypertension guidelines. Angiotensin receptor blockers (ARBs) were the most commonly prescribed drugs, given to 79% of patients, followed by calcium channel blockers (CCBs) at 55%. Diuretics and beta‐blockers (BBs) were prescribed to 27% and 17% of patients, respectively. Monotherapy was administered to 35% of patients, while combination therapies were more prevalent, with dual therapy at 51% and regimens involving three or more drugs prescribed to 14%. Among multi‐drug treatments (n = 3082, 65%), 98% received fixed‐dose combination tablets. The most common combinations were ARB + CCB (26%), ARB + diuretic (12%), and ARB + CCB + diuretic (8%). Key predictors for an increasing number of prescribed drugs included statin use/dyslipidemia, age, blood pressure level, and diabetes. Non‐adherence to hypertension guidelines was evident as 1364 patients classified from moderate to very high risk received monotherapy. Of these, 496 patients had grade 2 or 3 hypertension. Additionally, 88 patients received the undesirable combination of ACEi + ARB, and 267 (15.9%) type 2 diabetes mellitus (T2DM) patients did not receive RAS‐blockers (146 on monotherapy). The findings reveal a trend toward utilizing ARBs, CCBs, and combination tablets, indicating improved adherence to guidelines. However, a significant number of patients did not receive appropriate treatment, highlighting areas for improvement in prescription practices.
miR‐143‐3p/TET1 Axis Regulates GPC1 Through DNA Methylation and Impairs the Malignant Biological Behaviour of HCC via the Hippo Signalling Pathway
Authors: Liu Yan , Du Di , Gu Xue , He Qing , Xiong Bin
Published: January 2025

Hepatocellular carcinoma (HCC) is a malignant tumour that poses a serious threat to human health and places a heavy burden on individuals and society. However, the role of GPC1 in the malignant progression of HCC is unknown. In this study, we analysed the expression of GPC1 in HCC, and its association with poor patient prognosis. The effects of GPC1 on the proliferation, invasion and migration of HCC were analysed through cellular functional experiments in vitro and in vivo. Mechanistically, DNA methylation of GPC1 was analysed by DNA extraction, methylation‐specific PCR and bisulfite Sanger sequencing (BSP), and the target genes TET1 and miRNA regulating DNA methylation of GPC1 were found through the bioinformatics database. The results revealed that GPC1 was highly expressed in HCC, and its high expression was significantly associated with poor prognosis of HCC patients. Inhibiting the expression of GPC1 can inhibit the proliferation, invasion and migration of HCC cells. GPC1 was hypomethylated in HCC, and its methylation level was regulated by TET1. miR‐143‐3p can significantly regulated the expression of TET1 and affect the methylation level and protein expression of GPC1. Furthermore, GPC1 also affects the malignant biological behaviour of HCC by regulating the expression of Hippo signalling pathway. In summary, miR‐143‐3p regulates the expression of TET1, affects the expression of GPC1 through DNA methylation and regulates the malignant progression of HCC via Hippo signalling pathway.
Aucubin Promotes BMSCs Proliferation and Differentiation of Postmenopausal Osteoporosis Patients by Regulating Ferroptosis and BMP2 Signalling
Authors: Zheng Yang , Sun Rongtai , Yang Huan , Gu Tianyuan , Han Meichun , Yu Congcong , Chen Pengyu , Zhang Jianhua , Jiang Ting , Ding Yangyang , Liang Long , Quan Renfu , Yao Shasha , Zhao Xing
Published: January 2025

Postmenopausal osteoporosis (PMOP) is a chronic systemic bone metabolism disorder. Promotion in the patterns of human bone marrow mesenchymal stem cells (hBMSCs) differentiation towards osteoblasts contributes to alleviating osteoporosis. Aucubin, a natural compound isolated from the well‐known herbal medicine Eucommia, was previously shown to possess various pharmacological effects. However, its effects on hBMSCs of PMOP patients are unknown. The aim of this present research was to investigate the impact and underlying process of aucubin on cell proliferation and osteogenic differentiation in hBMSCs isolated from PMOP patients. The ability of aucubin to inhibit the ferroptosis induced by erastin in hBMSCs was detected; ROS production, ferrous ion levels, SOD, MDA, and GPX activities were tested by using commercial kits. Next, ALP staining, ARS staining, RT‐qPCR, RNA‐sequencing, and Western blot were applied for determining the mRNA and protein expression levels associated with the osteogenesis of hBMSCs. The study also explored the involvement of BMP2/Smads signalling in aucubin promoting the osteogenesis of hBMSCs and evaluated the effects of aucubin intervention on osteoporosis using an ovariectomised rat model. The results indicated that aucubin significantly inhibited ROS generation and oxidative stress induced by erastin and protected against ferroptosis in hBMSCs. Additionally, aucubin facilitated osteogenic differentiation of hBMSCs by activating the BMP2/SMADs pathway and attenuated the progression of osteoporosis in OVX rats, suggesting a potential therapeutic benefit for postmenopausal osteoporosis (PMOP).
Cellular Senescence Genes as Cutting‐Edge Signatures for Abdominal Aortic Aneurysm Diagnosis: Potential for Innovative Therapeutic Interventions
Authors: Zhang Shuli , Li Jiayin , Wang Ruichen , Zhao Xiaojie , Mei Zhu , Wang Xiaozeng
Published: January 2025

Abdominal aortic aneurysm (AAA) is the most prevalent dilated arterial aneurysm that poses a significant threat to older adults, but the molecular mechanisms linking senescence to AAA progression remain poorly understood. This study aims to identify cellular senescence‐related genes (SRGs) implicated in AAA development and assess their potential as therapeutic targets. Four hundred and twenty‐nine differentially expressed genes (DEGs) were identified from the GSE57691 training set, and 867 SRGs were obtained. Through the intersection of DEGs with SRGs, 19 differentially expressed senescence‐related genes (DESRGs) were uncovered. Functional enrichment analysis was performed to explore their biological roles in AAA. To identify hub genes, we applied machine learning algorithms, including LASSO, SVM‐RFE and random forest. These hub genes were then validated in two independent datasets. In the initial validation cohort, significant differences in the expression levels of BTG2, ETS1, ID1 and ITPR3 were observed between the AAA and control groups. Receiver operating characteristic (ROC) analysis demonstrated a robust diagnostic performance. Further validation across different AAA stages (small, large and ruptured AAA) identified ETS1 and ITPR3 as potential diagnostic genes. Subsequently, the diagnostic relevance of ETS1 and ITPR3 was further validated in human serum samples and mouse models of AAA. In addition, single‐cell RNA sequencing suggests that senescent endothelial cells play a pivotal role in AAA progression, we further confirmed the correlation between ETS1 and ITPR3 and senescent endothelial cells by WB, IF and RT‐qPCR. In conclusion, our study reveals the pivotal role of cellular senescence in AAA progression and identifies ETS1 and ITPR3 as promising diagnostic biomarkers.
Lay Theories of Expertise: A Mixed‐Methods Exploration
Authors: Keating Lauren A. , Walker Benjamin W.
Published: January 2025

Failure to engage with expertise underpins many organizational and societal problems. Despite decades of research on expertise, we still do not fully understand why such failures persist, and there is a sense that these failures are becoming a crisis of expertise. In this article, we highlight a person's system of beliefs about the meaning of expertise – what we term their lay theory of expertise (LTE) – as an important factor for understanding their engagement with expertise. Through a free response study (Study 1), analysis of social media data (Study 2), and word sorting study (Study 3), we first develop a taxonomy of common LTE elements. We then examine how LTEs affect expert recognition via two experiments with managers (Studies 4 and 5). Study 4 reveals that congruence between the most psychologically active element of a person's lay theory and expert conduct is conducive to expert recognition, while Study 5 highlights that (in)congruence between LTEs and expert conduct can alter how other mental representations (such as gender stereotypes) shape expert recognition. Our work provides a conceptual foundation for exploring variation in the subjective meaning of expertise in future research on expert recognition and engagement, both within and beyond organizations.
Locally Specific Genome‐Wide Signatures of Adaptation to Environmental Variation at High Resolution in an Alpine Plant
Authors: Rogivue Aude , Leempoel Kevin , Guillaume Annie S. , Choudhury Rimjhim Roy , Felber François , Kasser Michel , Joost Stéphane , Parisod Christian , Gugerli Felix
Published: January 2025

Microevolutionary processes shape adaptive responses to heterogeneous environments, where these effects vary both among and within species. However, it remains largely unknown to which degree signatures of adaptation to environmental drivers can be detected based on the choice of spatial scale and genomic marker. We studied signatures of local adaptation across two levels of spatial extents, investigating complementary types of genomic variants—single‐nucleotide polymorphisms (SNPs) and polymorphic transposable elements (TEs)—in populations of the alpine model plant species Arabis alpina . We coupled environmental factors, derived from remote sensed digital elevation models (DEMs) at very high resolution (0.5 m), with whole‐genome sequencing data of 304 individuals across four populations. By comparing putatively adaptive loci detected between each local population versus a regional assessment including all populations simultaneously, we demonstrate that responses of A. alpina to similar amounts of abiotic variation are largely governed by local evolutionary processes. Furthermore, we find minimally overlapping signatures of local adaptation between SNPs and polymorphic TEs. Notably, functional annotations of candidate genes for adaptation revealed several symbiosis‐related genes associated with the abiotic factors studied, which could represent selective pressures from biotic agents. Our results highlight the importance of considering different spatial extents and types of genomic polymorphisms when searching for signatures of adaptation to environmental variation. Such insights provide key information on microevolutionary processes and could guide management decisions to mitigate negative impacts of climate change on alpine plant populations.
ECG‐Gated Cardiac Multidetector CT Evaluation of the Normal Pulmonary Valve and Right Ventricular Outflow Tract in Dogs
Authors: Massarenti Chiara , Croce Marta , Diana Alessia , Tursi Massimiliano , Zini Eric , Domenech Oriol , Auriemma Edoardo
Published: January 2025

With the advancement in imaging technology, ECG‐gated cardiac multidetector computed tomography (MDCT) has emerged as a tool for the anatomic evaluation of the pulmonary valve and right ventricular outflow tract (RVOT) in human medicine. Currently, the evaluation of the pulmonary valve relies primarily on echocardiographic examination. However, the bi‐dimensional nature of this technique and the location/orientation of the pulmonary valve in the thoracic cavity can pose challenges. In human medicine, ECG‐gated MDCT distinguishes four main anatomic components of the pulmonary valve and RVOT: the pulmonary valve leaflets, the sinotubular junction, the anatomic ventriculo‐arterial junction and the hemodynamic ventriculo‐arterial junction. Hence, this study aimed to describe the computed tomographic findings of the normal RVOT and pulmonary cusps in a population of dogs.

This is an anatomic prospective descriptive study. A total of 24 dogs underwent a complete echocardiographic examination and an ECG‐gated MDCT to rule out pulmonary valve abnormalities. Multiplanar reconstruction of the pulmonary valve was obtained. Additionally, hearts from three dogs euthanized for reasons unrelated to the study were collected and their gross and histological findings were compared with the CT images. The ECG‐gated MDCT provided good visualization of the pulmonary valve leaflets, the sinotubular junction, the anatomic ventriculo‐arterial junction and the hemodynamic ventriculo‐arterial junction. Notably, the short‐axis view of the pulmonary valve anatomy resembled the ‘Mercedes‐Benz sign’ characteristic of the aortic valve in all dogs. In conclusion, this study provides the first description of the CT anatomy of the RVOT in dogs without pulmonary valve and RVOT abnormalities.
Geochronology and thermal history of the Mount Everest massif
Authors: Larson Kyle P. , Cottle John M. , Shrestha Sudip , Button Mark , Camacho Alfredo , Steele-MacInnis Matthew , Lageson David , Creighton Steven
Published: January 2025

New
in situ
apatite U–Pb and mica Rb–Sr and
40
Ar/
39
Ar geochronology outline a break in geochronology within the Mount Everest massif at an elevation of
c
. 8000 m. Above the break, most chronometers record dates from the Eocene epoch, whereas below, most dates are from the Middle Miocene epoch. Raman spectroscopy of carbonaceous material and Ti-in-biotite-based thermometry results outline a break in temperatures at the same elevation. From the summit downwards, temperatures increase to a maximum of
c
. 500°C at
c
. 8500 m before decreasing to
c
. 400°C at
c
. 7900 m. The coinciding breaks in the independent datasets are interpreted to reflect movement along a previously unrecognized structure, here termed the Adrishya thrust that was active
c.
18 Ma. The Adrishya thrust may reflect re-equilibration of the evolving orogenic wedge, perhaps further influenced by cooling and strain localization structurally away from the exhuming orogenic core.
Augmentation with Neighboring Information for Conversational Recommendation
Authors: Liu Yuanxing , Pei Jiahuan , Zhang Wei-Nan , Li Ming , Che Wanxiang , de Rijke Maarten
Published: January 2025

Conversational recommender systems (CRSs) suggest items to users by understanding their needs and preferences from natural language conversations. While users can freely express preferences, modeling needs and preferences solely from users’ conversations is challenging due to the sparsity of the available information. Prior work introduces external resources to enrich information expressed in conversations. Obtaining such resources is challenging and not always effective. Can learning intrinsic relations among conversations and items enhance information without the use of external resources? Inspired by collaborative filtering, we propose to use so-called neighboring relations within training data, i.e., relations between conversations, items, and similar conversations and items, to enhance our algorithmic understanding of CRSs.

We propose a neighboring relations enhanced conversational recommender system (NR-CRS) and study how neighboring relations improve CRSs from two angles: (i) We mine preference information from neighboring conversations to enhance the modeling of user representations and learning of user preferences. (ii) We generate negative samples based on neighboring items to extend the data available for training CRSs. Experiments on the
ReDial
dataset show that neighboring relations enhanced conversational recommender system (NR-CRS) outperforms the state-of-the-art baseline by 11.3–20.6% regarding recommendation performance while generating informative and diverse responses. We also assess the capabilities of large language models (i.e., Llama 2, Llama 3, and Chinese-Alpaca2) for CRSs. While the generated responses exhibit enhanced fluency and informativeness, recommending target items with LLMs remains challenging; we recommend that LLMs be used as a decoding base for NR-CRS to generate relevant and informative responses.
Thought-Feeling Accuracy in Person Perception and Metaperception: An Integrative Perspective
Authors: Vorauer Jacquie D. , Hodges Sara D. , Hall Judith A.
Published: January 2025

People often want to know what their interaction partners are thinking. How accurate are they, what information do they use, what predicts how accurate they will be, and does accuracy matter? We organize our review of thought-feeling accuracy, defined as the accuracy of individuals’ judgments about the content of another person's thoughts and feelings in live interaction, around these questions. At the same time, we argue that often people are especially interested in what others are thinking about them, such that research on the accuracy of individuals’ metaperceptions regarding others’ views of them is highly relevant to understanding thought-feeling accuracy more broadly construed. In particular, we maintain that systematic biases characterizing individuals’ spontaneous metaperceptions are an important source of preventable and harmful forms of thought-feeling inaccuracy. We advocate for integration across the thought-feeling accuracy and meta-accuracy literatures so as to generate new insights that can move them both forward.
Optical Fiber Mediated Biosensors for Multiplex and Onsite Food Safety Analysis: A Review
Authors: Hameed Sara , Naz Iram , Badea Mihaela , Bano Nargis , Andreescu Silvana , Hayat Akhtar , Jubeen Farhat
Published: January 2025

The presence of unsafe levels of chemical compounds, toxins, and pathogens in food poses a serious threat to public health, especially in economically disadvantaged countries. Current detection methods are costly, require centralized labs, skilled personnel, and specialized equipment, hindering large-scale testing. Here we provide a comprehensive review of optical fiber (OF)-based biosensors for multiplex detection of analytes in food. It covers fiber modification strategies to enhance multiplexing capacity by incorporating multiple independent detection regions. The review classifies OF multiplexing detection principles into label and label-free approaches for antibody and aptamer-based biosensing, comparing their characteristics and applications in food matrices. Despite challenges like multiplexing capacity and complex instrumentation, the review outlines promising prospects for achieving portable, rapid, accurate, and intelligent multiplexing for food safety.
Differentiating the contributions of Na+/K+ pump current and persistent Na+ current in simulated voltage-clamp experiments
Authors: Parker Jessica R. , Ramirez Jan-Marino
Published: January 2025

The slow inactivation of the persistent Na+ current has been implicated in numerous neuronal functions. Our computational approach indicates that voltage-clamp experiments may show a slow inactivation that is actually caused by the Na+/K+ pump current and a changing Na+ reversal potential rather than a slow Na+ inactivation process. These results call into question to what extent the slow inactivation of the persistent Na+ current is solely important for neuronal functions.
Beyond sight: environmental interaction with the hands or feet?
Authors: Vanderkolff Samia M. , Maibauer Isaac , Amin Niyati
Published: January 2025

How humans perceive the texture of a surface can inform and guide how their interaction takes place. From grasping a glass to walking on icy steps, the information we gather from the surfaces we interact with is instrumental to the success of our movements. However, the hands and feet differ in their ability to explore and identify textures. Higher concentrations of mechanoreceptors in the fingertips provide tactile information to help modulate force and grip whereas the receptors of the feet help to inform surface texture and aid in balance. Cleland et al. ( J Neurophysiol 132: 643–652, 2024), explores the relationship between texture perception, mode of exploration, and region of body used to explore said texture (hands vs. feet). This research is especially important in the context of understanding how texture perception affects stability, how hands and feet differ in their management and execution of tasks, and how this is adjusted in special populations of visually impaired individuals.
Ultrasound in deep endometriosis: A narrative review
Authors: Guerriero Stefano , Oyarce Fernanda Harumi , Filippi Francesca , Rolla Martino , Pedrassani Marcelo , Alcázar Juan Luis , Pascual M. Angela , Pagliuca Mariachiara , Borzacchelli Antonietta , Deiala Fabio , Pisu Annalisa , Medas Alessandra , Piras Barbara , Desogus Camilla , Ajossa Silvia
Published: January 2025

Background
Over the past decade, transvaginal ultrasound (TVUS) has revolutionized the diagnosis of deep endometriosis. We can now accurately describe and evaluate lesions in multiple compartments of the pelvis, increasing diagnostic capacity without the need for initial laparoscopy. Recent consensus and publications support the new and growing evidence for this technique. Research into deep endometriosis has increased substantially and new diagnostic evidence is now available.

Objectives
The aim of this article is to review the state of the art in ultrasound diagnosis of deep endometriosis.

Methods
We performed a detailed search of the PubMed database to identify eligible primary studies. We included English-language publications with the following terms: "endometriosis" AND "deep" AND "ultrasound" AND "transvaginal". Studies focusing on ultrasound in deep endometriosis were included, we selected them based on title reading, then narrowed the selection by reading the abstract. -We excluded publications that didn't use TVUS as one of the main techniques to evaluate deep endometriosis.

Results
243 studies were identified and selected as described above, resulting in a total of 73 studies included in this review.

Conclusions and outlook
Our understanding of deep endometriosis has evolved over the past decade. Efforts have been made to reduce the diagnostic delay in this common disease, particularly with the increased use of imaging, especially transvaginal ultrasound, as a first-line diagnostic modality because of its availability, good test performance, cost-effectiveness, and low environmental impact compared to other imaging modalities. This statement is supported by recent publications and guidelines from some medical societies. Advances in technology, equipment and research have allowed us to identify additional compartments involved, including the parametrium. The progress made in recent years offers hope for earlier detection and improved management of patients with suspected endometriosis who suffer not only from pelvic pain but also from infertility.