bluuebunny/crossref_metadata_2025 huggingface dataset:
Overview of Neuro-Ophthalmic Findings in Leukodystrophies
Authors: Bettinger Charlotte Maria , Dulz Simon , Atiskova Yevgeniya , Guerreiro Helena , Schön Gerhard , Guder Philipp , Maier Sarah Lena , Denecke Jonas , Bley Annette E.
Published: August 2024

Background: Leukodystrophies are a group of rare genetic diseases that primarily affect the white matter of the central nervous system. The broad spectrum of metabolic and pathological causes leads to manifestations at any age, most often in childhood and adolescence, and a variety of symptoms. Leukodystrophies are usually progressive, resulting in severe disabilities and premature death. Progressive visual impairment is a common symptom. Currently, no overview of the manifold neuro-ophthalmologic manifestations and visual impact of leukodystrophies exists. Methods: Data from 217 patients in the Hamburg leukodystrophy cohort were analyzed retrospectively for neuro-ophthalmologic manifestations, age of disease onset, and magnetic resonance imaging, visual evoked potential, and optical coherence tomography findings and were compared with data from the literature. Results: In total, 68% of the patients suffered from neuro-ophthalmologic symptoms, such as optic atrophy, visual neglect, strabismus, and nystagmus. Depending on the type of leukodystrophy, neuro-ophthalmologic symptoms occurred early or late during the course of the disease. Magnetic resonance imaging scans revealed pathologic alterations in the visual tract that were temporally correlated with symptoms. Conclusions: The first optical coherence tomography findings in Krabbe disease and metachromatic leukodystrophy allow retinal assessments. Comprehensive literature research supports the results of this first overview of neuro-ophthalmologic findings in leukodystrophies.
Cocaine- and Levamisole-Induced Vasculitis: Defining the Spectrum of Autoimmune Manifestations
Authors: Iorio Luca , Davanzo Federica , Cazzador Diego , Codirenzi Marta , Fiorin Eleonora , Zanatta Elisabetta , Nicolai Piero , Doria Andrea , Padoan Roberto
Published: August 2024

Drug-induced or associated vasculitis is a prevalent form of vasculitis that resembles primary idiopathic antineutrophil cytoplasmic autoantibody (ANCA) vasculitis (AAV). Cocaine is a diffuse psychostimulant drug and levamisole is a synthetic compound used to cut cocaine. Their abuse may result in a spectrum of autoimmune manifestations which could be categorized into three overlapping clinical pictures: cocaine-induced midline destructive lesion (CIMDL), levamisole-adulterated cocaine (LAC) vasculopathy/vasculitis, and cocaine-induced vasculitis (CIV). The mechanisms by which cocaine use leads to disorders resembling AAV are not well understood. Cocaine can cause autoimmune manifestations ranging from localized nasal lesions to systemic diseases, with neutrophils playing a key role through NETosis and ANCA development, which exacerbates immune responses and tissue damage. Diagnosing and treating these conditions becomes challenging when cocaine and levamisole abuse is not suspected, due to the differences and overlaps in clinical, diagnostic, therapeutic, and prognostic aspects compared to primary idiopathic vasculitides.
Language Choice and the Problematics of Ideology in the Pre- and Post-Independence Ghanaian Press: A Historical and Cultural Analysis
Authors: Fosu Modestus
Published: August 2024

This study adds to the existing literature on the history of the Ghanaian press from pre-colonial times to 1992, focusing on language: its choice and ideological, socio-cultural, and political ramifications. While the history of the press has received massive scholarly attention, the same cannot be said of language and its use in historical accounts. Thus, from a historical research perspective, employing an analytical and interpretive study of secondary data sources, and underpinned by cultural theories such as linguistic imperialism and hegemony, this study analyses how language was featured in the press during the research period and the implications thereof. This analysis shows that various institutions and individuals exploited language to foster narrow socio-cultural, ideological, and political agendas in the Gold Coast, later Ghana. This study also revealed that language use and its ideological forces during the pre- and immediate post-independence periods contributed immensely to Ghanaian media’s current state and Ghanaians’ general language attitudes. This study’s significance lies in the realisation that language, as a cultural artifact, and its choice, use, and consumption could have far-reaching consequences for the self-realisation, actualisation, and general progress of a society. Thus, African societies should be mindful of the ideological implications of language choices not just in the press but also in other societal contexts. This study, therefore, invites further studies on language and its use in the media, especially from 1992, for a more comprehensive appreciation of the issues raised in this study.
Impact of Urbanization-Driven Land Use Changes on Runoff in the Upstream Mountainous Basin of Baiyangdian, China: A Multi-Scenario Simulation Study
Authors: Gong Yuan , Geng Xin , Wang Ping , Hu Shi , Wang Xunming
Published: August 2024

Urbanization in the Haihe River Basin in northern China, particularly the upstream mountainous basin of Baiyangdian, has significantly altered land use and runoff processes. The runoff is a key water source for downstream areas like Baiyangdian and the Xiong’an New Area, making it essential to understand these changes’ implications for water security. However, the exact implications of these processes remain unclear. To address this gap, a simulation framework combining SWAT+ and CLUE-S was used to analyze runoff responses under different land use scenarios: natural development (ND), farmland protection (FP), and ecological protection (EP). The model simulation results were good, with NSE above 0.7 for SWAT+. The Kappa coefficient for CLUE-S model validation was 0.83. The further study found that from 2005 to 2015, urban construction land increased by 11.50 km2 per year, leading to a 0.5–1.3 mm rise in annual runoff. Although urban expansion continued, the other scenarios, which emphasized farmland and forest preservation, slowed this growth. Monthly runoff changes were most significant during the rainy season, with annual runoff in ND, FP, and EP varying by 8.9%, 10.9%, and 7.7%, respectively. While the differences in annual runoff between scenarios were not dramatic, these findings provide a theoretical foundation for future water resource planning and management in the upstream mountainous area of Baiyangdian and offer valuable insights for the sustainable development of Xiong’an New Area. Additionally, these results contribute to the broader field of hydrology by highlighting the importance of considering multiple land use scenarios in runoff change analysis.
Uncertainty Assessment of Species Distribution Prediction Using Multiple Global Climate Models on the Tibetan Plateau: A Case Study of Gentiana yunnanensis and Gentiana siphonantha
Authors: Song Yuxin , Xu Xiaoting , Zhang Shuoying , Chi Xiulian
Published: August 2024

Species distribution models (SDMs) have been widely used to project how species respond to future climate changes as forecasted by global climate models (GCMs). While uncertainties in GCMs specific to the Tibetan Plateau have been acknowledged, their impacts on species distribution modeling needs to be explored. Here, we employed ten algorithms to evaluate the uncertainties of SDMs across four GCMs (ACCESS-CM2, CMCC-ESM2, MPI-ESM1-2-HR, and UKESM1-0-LL) under two shared socioeconomic pathways (SSP2-4.5 and SSP5-8.5) at two time stages. We selected two endemic species of the Tibetan Plateau, Gentiana yunnanensis and G. siphonantha, distributed in the Hengduan Mountain regions of the southeast plateau and northeast plateau regions, respectively, as case studies. Under the two SSPs and two time periods, there are significant differences in the distribution areas of G. yunnanensis predicted by different GCMs, with some showing increases and others showing decreases. In contrast, the distribution range trends for G. siphonantha predicted by different GCMs are consistent, initially increasing and then decreasing. The CMCC-ESM2 model predicted the largest increase in the distribution range of G. yunnanensis, while the UKESM1-0-LL model predicted the greatest decrease in the distribution range of G. siphonantha. Our findings highlight that the four selected GCMs still lead to some variations in the final outcome despite the existence of similar trends. We recommend employing the average values from the four selected GCMs to simulate species potential distribution under future climate change scenarios to mitigate uncertainties among GCMs.
Use of an Adaptive-Vegetation Model to Restore Degraded Tropical Peat Swamp Forest to Support Climate Resilience
Authors: Dharmawan I. Wayan Susi , Lisnawati Yunita , Siahaan Hengki , Premono Bambang Tejo , Iqbal Mohamad , Junaedi Ahmad , Sakuntaladewi Niken , Bastoni  , Fauzi Ridwan , Ramawati  , Nugroho Ardiyanto Wahyu , Undaharta Ni Kadek Erosi , Achmadi Anang Setiawan , Setyawati Titiek , Siregar Chairil Anwar , Pratiwi  , Suhartana Sona , Soenarno  , Dulsalam  , Sukmana Asep
Published: August 2024

Climate change poses significant challenges to ecosystems globally, demanding innovative methods for environmental conservation and restoration. Restoration initiatives require significant amounts of appropriate vegetation that is both adaptive and tolerant to the specific environmental factors. This study introduces an adaptive-vegetation model designed to support ecosystem resilience in the face of climate change. Traditional restoration methods often neglect dynamic environmental conditions and ecosystem interactions, but the model employs real-time data and predictive analytics to adapt strategies to evolving climate variables. The model takes a comprehensive approach, incorporating climate projections, soil health metrics, species adaptability, and hydrological patterns to inform restoration practices. By using a mix of adaptable native species, the model promotes biodiversity. In conclusion, according to the findings of our review, paludiculture and agroforestry could be implemented as models for improving climate resilience, particularly in tropical degraded peat swamp forests. These two models could improve the environment, the economy, and social functions. Finally, improving all three of these factors improves ecological stability. This adaptive-vegetation model represents a significant shift from static, uniform restoration approaches to dynamic, data-driven strategies tailored to specific environments. The future research directions underscore the need for ongoing innovation in conservation practices to safeguard ecosystems amid unprecedented environmental changes. Future efforts will focus on enhancing the model with advanced machine learning techniques and expanding its application to additional ecological contexts.
Study on Grouting Performance Optimization of Polymer Composite Materials Applied to Water Plugging and Reinforcement in Mines
Authors: Zhang Xuanning , Wang Ende , Ma Sishun , Zhang Deqing
Published: August 2024

With the increasing drilling depth of mines, the cross-complexity of fissures in the rock body, and the frequent occurrence of sudden water surges, polymer slurry, with its advantages of good permeability and strong water plugging, is increasingly used in mine grouting projects. Additional research is needed in order to further improve the grouting performance of polymer slurry, ensure the safety of mining operations, and reduce the grouting cost. In this paper, a polymer composite grouting material was prepared with diphenyl methyl diisocyanate, polyether polyol, and fly ash, as the main raw materials, with coupling agent and catalyst as auxiliary reagents. The performance of the composite grouting material in terms of mechanical properties, thermal stability, hydrophobicity, and bonding was explored. This study’s findings indicated that incorporating fly ash led to notable enhancements in the thermal stability and water resistance of the polymer slurry. Furthermore, the introduction of fly ash notably raised the starting degradation temperature of the polymer, boosted the water contact angle of the composite material, and reduced the density and reaction temperature of the composite material. In addition, the catalyst and coupling agent as auxiliary reagents affected the polymers in terms of mechanical properties; in this paper, dibutyltin dilaurate was used as the catalyst, and organosilanes were used as the coupling agent. The catalyst successfully sped up the polymer’s gel time, however, an excessive quantity of catalyst compromised the polymer’s mechanical characteristics. The addition of organosilanes has a positive effect on the dynamic mechanical properties of the composites, fracture toughness, compression, bending, and bond strength. The research can offer a theoretical direction for creating polymer mixtures in mine grouting projects.
Optical Properties and Growth Characteristics of 8-Quinolinolato Lithium (Liq) Nano-Layers Deposited by Gas Transport Deposition
Authors: Zachariadis Alexandros , Chatzidis Michalis , Tselekidou Despoina , Wurzinger Olaf , Keiper Dietmar , Baumann Peter K. , Heuken Michael , Papadopoulos Kyparisis , Laskarakis Argiris , Logothetidis Stergios , Gioti Maria
Published: August 2024

Organometallic complexes containing reactive alkali metals, such as lithium (Li), represent a promising material approach for electron injection layers and electron transport layers (EILs and ETLs) to enhance the performance of Organic Light-Emitting Diodes (OLEDs). 8-Quinolinolato Lithium (Liq) has shown remarkable potential as an EIL and ETL when conveyed in very thin films. Nevertheless, the deposition of nano-layers requires precise control over both thickness and morphology. In this work, we investigate the optical properties and morphological characteristics of Liq thin films deposited via Organic Vapor Phase Deposition (OVPD). Specifically, we present our methodology for analyzing the measured pseudodielectric function <ε(ω)> using Spectroscopic Ellipsometry (SE), alongside the nano-topography of evaporated Liq nano-layers using Atomic Force Microscopy (AFM). This information can contribute to the understanding of the functionality of this material, since ultra-thin Liq interlayers can significantly increase the operational stability of OLED architectures.
The Cytoprotective Effect of C60 Derivatives in the Self-Microemulsifying Drug Delivery System against Triptolide-Induced Cytotoxicity In Vitro
Authors: Xu Beihua , Wang Zhenyu , Zhang Huimin , Xu Xiao , Tang Mengjie , Wang Gang , Ding Zhongpeng , Yu Ruihao , Ding Meihong , Zhang Ting , Shi Senlin
Published: August 2024

Objective: The aim of this study was to optimize the formulation of a C60-modified self-microemulsifying drug delivery system loaded with triptolide (C60-SMEDDS/TP) and evaluate the cytoprotective effect of the C60-SMEDDS/TP on normal human cells. Results: The C60-SMEDDS/TP exhibited rapid emulsification, an optimal particle size distribution of 50 ± 0.19 nm (PDI 0.211 ± 0.049), and a near-neutral zeta potential of −1.60 mV. The release kinetics of TP from the C60-SMEDDS/TP exhibited a sustained release profile and followed pseudo-first-order release kinetics. Cellular proliferation and apoptosis analysis indicated that the C60-SMEDDS/TP (with a mass ratio of TP: DSPE-PEG-C60 = 1:10) exhibited lower toxicity towards L02 and GES-1 cells. This was demonstrated by a higher IC50 (40.88 nM on L02 cells and 17.22 nM on GES-1 cells) compared to free TP (21.3 nM and 11.1 nM), and a lower apoptosis rate (20.8% on L02 cells and 26.3% on GES-1 cells, respectively) compared to free TP (50.5% and 47.0%) at a concentration of 50 nM. In comparison to the free TP group, L02 cells and GES-1 cells exposed to the C60-SMEDDS/TP exhibited a significant decrease in intracellular ROS and an increase in mitochondrial membrane potential (ΔψM). On the other hand, the C60-SMEDDS/TP demonstrated a similar inhibitory effect on BEL-7402 cells (IC50 = 28.9 nM) and HepG2 cells (IC50 = 107.6 nM), comparable to that of the free TP (27.2 nM and 90.4 nM). The C60-SMEDDS/TP group also exhibited a similar intracellular level of ROS and mitochondrial membrane potential compared to the SMEDDS/TP and free TP groups. Method: Fullerenol-Grafted Distearoyl Phosphatidylethanolamine-Polyethylene Glycol (DSPE-PEG-C60) was synthesized and applied in the self-microemulsifying drug delivery system. The C60-SMEDDS/TP was formulated using Cremophor EL, medium-chain triglycerides (MCT), PEG-400, and DSPE-PEG-C60, and loaded with triptolide (TP). The toxicity and bioactivity of the C60-SMEDDS/TP were assessed using normal human liver cell lines (L02 cells), normal human gastric mucosal epithelial cell lines (GES-1 cells), and liver cancer cell lines (BEL-7402 cells and HepG2 cells). The production of reactive oxygen species (ROS) after the C60-SMEDDS/TP treatment was assessed using 2′,7′-dichlorofluorescein diacetate (DCFDA) staining. The alterations in mitochondrial membrane potential (ΔψM) were assessed by measuring JC-1 fluorescence. Conclusions: The cytoprotection provided by the C60-SMEDDS/TP favored normal cells (L02 and GES-1) over tumor cells (BEL-7402 and HepG2 cells) in vitro. This suggests a promising approach for the safe and effective treatment of TP.
Untargeted Metabolomics Analysis of Lactic Acid Bacteria Fermented Acanthopanax senticosus with Regard to Regulated Gut Microbiota in Mice
Authors: Su Yuanyuan , Fu Xiang , Zhuang Pengwei
Published: August 2024

Previous studies have shown that Acanthopanax senticosus (AS) has a beneficial preventive and therapeutic effect on colitis. The fermentation of lactic acid bacteria (LAB) can alter the efficacy of AS by modifying or producing new compounds with potential bioactive properties. However, the specific components and mechanisms that enhance the efficacy are still unclear. In the present experiment, untargeted metabolomics was used to analyze the changes in active components before and after LAB fermentation of AS. The aim was to explain the mechanism of AS fermentation in treating colitis using a colitis model in mice. The results indicated that the fermentation of LAB could enhance the levels of total flavonoids and total polyphenols in FAS. Additionally, the beneficial components such as Delphinidin chloride, Diosmetin, Psoralidin, and Catechol significantly increased (p < 0.05). The colitis treatment experiment demonstrated that fermented AS could alleviate symptoms and improve the morphology of colitis in mice by enhancing antioxidant enzymes like CAT, T-SOD, and T-AOC. It also regulated the composition and abundance of intestinal flora species, such as Lactobacillus and Pseudogracilibacillus. The effectiveness of fermented AS was significantly superior to that of unfermented AS (p < 0.05). In conclusion, this study contributes to the application of lactic acid bacteria in AS fermentation and reveals the mechanism of fermentation AS for colitis.
Synthesis and Photocatalytic sp3 C-H Bond Functionalization of Salen-Ligand-Supported Uranyl(VI) Complexes
Authors: He Jialu , Gong Xingxing , Li Yafei , Zhao Qianyi , Zhu Congqing
Published: August 2024

Recent years have seen increasing interest in uranyl(VI) photocatalysis. In this study, uranyl complexes were successfully synthesized from ligands L1–L6 and UO2(NO3)2·6H2O under reflux conditions, yielding products 1–6 with yields ranging from 30% to 50%. The complexes were thoroughly characterized using NMR spectroscopy, single-crystal X-ray diffraction, and elemental analysis. The results indicate that complexes 1–5 possess a pentagonal bipyramidal geometry, whereas complex 6 exhibits an octahedral structure. The photocatalytic properties of these novel complexes for sp3 C-H bond functionalization were explored. The results demonstrate that complex 4 functions as an efficient photocatalyst for converting C-H bonds to C-C bonds via hydrogen atom transfer under blue light irradiation.
Advancements in the Heterologous Expression of Sucrose Phosphorylase and Its Molecular Modification for the Synthesis of Glycosylated Products
Authors: Zhang Hongyu , Zhu Leting , Zhou Zixuan , Wang Danyun , Yang Jinshan , Wang Suying , Lou Tingting
Published: August 2024

Sucrose phosphorylase (SPase), a member of the glycoside hydrolase GH13 family, possesses the ability to catalyze the hydrolysis of sucrose to generate α-glucose-1-phosphate and can also glycosylate diverse substrates, showcasing a wide substrate specificity. This enzyme has found extensive utility in the fields of food, medicine, and cosmetics, and has garnered significant attention as a focal point of research in transglycosylation enzymes. Nevertheless, SPase encounters numerous obstacles in industrial settings, including low enzyme yield, inadequate thermal stability, mixed regioselectivity, and limited transglycosylation activity. In-depth exploration of efficient expression strategies and molecular modifications based on the crystal structure and functional information of SPase is now a critical research priority. This paper systematically reviews the source microorganisms, crystal structure, and catalytic mechanism of SPase, summarizes diverse heterologous expression systems based on expression hosts and vectors, and examines the application and molecular modification progress of SPase in synthesizing typical glycosylated products. Additionally, it anticipates the broad application prospects of SPase in industrial production and related research fields, laying the groundwork for its engineering modification and industrial application.
One-Step Synthesis of Heterostructured Mo@MoO2 Nanosheets for High-Performance Supercapacitors with Long Cycling Life and High Rate Capability
Authors: Cheng Ao , Shen Yan , Cui Tao , Liu Zhe , Lin Yu , Zhan Runze , Tang Shuai , Zhang Yu , Chen Huanjun , Deng Shaozhi
Published: August 2024

Supercapacitors have gained increased attention in recent years due to their significant role in energy storage devices; their impact largely depends on the electrode material. The diversity of energy storage mechanisms means that various electrode materials can provide unique benefits for specific applications, highlighting the growing trend towards nanocomposite electrodes. Typically, these nanocomposite electrodes combine pseudocapacitive materials with carbon-based materials to form heterogeneous structural composites, often requiring complex multi-step preparation processes. This study introduces a straightforward approach to fabricate a non-carbon-based Mo@MoO2 nanosheet composite electrode using a one-step thermal evaporating vapor deposition (TEVD) method. This novel electrode features Mo at the core and MoO2 as the shell and demonstrates exceptional electrochemical performance. Specifically, at a current density of 1 A g−1, it achieves a storage capacity of 205.1 F g−1, maintaining virtually unchanged capacity after 10,000 charge–discharge cycles at 2 A g−1. The outstanding long-cycle stability is ascribed to the vertical two-dimensional geometry, the superior conductivity, and pseudocapacitance of the Mo@MoO2 core-shell nanosheets. These attributes significantly improve the electrode’s charge storage capacity, charge transfer speed, and structural integrity during the cycling process. The development of the one-step grown Mo@MoO2 nanosheets offers a promising way for the advancement of high-performance, non-carbon-based supercapacitor nanocomposite electrodes.
SnO2-Based Interfacial Engineering towards Improved Perovskite Solar Cells
Authors: Li Bing’e , Liu Chuangping , Zhang Xiaoli
Published: August 2024

Interfacial engineering is of great concern in photovoltaic devices. Metal halide perovskite solar cells (PSCs) have garnered much attention due to their impressive development in power conversion efficiencies (PCEs). Benefiting from high electron mobility and good energy-level alignment with perovskite, aqueous SnO2 as an electron transport layer has been widely used in n-i-p perovskite solar cells. However, the interfacial engineering of an aqueous SnO2 layer on PSCs is still an obscure and confusing process. Herein, we proposed the preparation of n-i-p perovskite solar cells with different concentrations of SnO2 as electron transport layers and achieved optimized PCE with an efficiency of 20.27%. I Interfacial engineering with regard to the SnO2 layer is investigated by observing the surface morphology, space charge-limited current (SCLC) with the use of an electron-only device, and time-resolved photoluminescence (TRPL) of perovskite films.
The Association between Federal Nutrition Assistance Programs and Adolescent Food Security during the COVID-19 Pandemic: Evidence from Baltimore, Maryland
Authors: Mmari Kristin , Harper Kaitlyn , Kawatachi Jon , Jenkins Marina , Gross Susan , Lu Stacy , Skinner Rebecca , Marshall Beth
Published: August 2024

Given the lack of attention on adolescent food insecurity, the primary objective of this study was to assess the association of household participation in federal food assistance programs with food security status among adolescents in Baltimore during the COVID-19 pandemic. Adolescents, ages 14–19 years, were invited to participate in two online surveys. The baseline was implemented between October 2020 and January 2021, while the follow-up took place one year later from November 2021 to January 2022 after schools had re-opened. We then matched survey participants with household participation in food nutrition assistance programs using data obtained from the Maryland Department of Social Services. We used logistic regression to examine the association between food assistance program participation status and food insecurity. Additionally, to examine whether the impact of program participation on food insecurity changed between the baseline survey and one year later at follow-up when schools re-opened, a difference-in-differences analysis was conducted. The results showed no significant associations between adolescent food security and participation in any of the federal nutrition assistance programs. Increased attention on how best to improve adolescent food security in low-income households that can respond to the unique needs of adolescents is clearly warranted.
The Impact of Japanese Dietary Patterns on Metabolic Dysfunction-Associated Steatotic Liver Disease and Liver Fibrosis
Authors: Sasada Takafumi , Iino Chikara , Sato Satoshi , Tateda Tetsuyuki , Igarashi Go , Yoshida Kenta , Sawada Kaori , Mikami Tatsuya , Nakaji Shigeyuki , Sakuraba Hirotake , Fukuda Shinsaku
Published: August 2024

This study aimed to investigate the effect of Japanese dietary patterns on metabolic dysfunction-associated steatotic liver disease (MASLD) and liver fibrosis. After excluding factors affecting the diagnosis of hepatic steatosis, 727 adults were analyzed as part of the Health Promotion Project. The dietary patterns of the participants were classified into rice, vegetable, seafood, and sweet based on their daily food intake. Liver stiffness measurements and controlled attenuation parameters were performed using FibroScan. Energy and nutrient intake were calculated using the Brief-type Self-administered Diet History Questionnaire. Univariate and multivariate analyses were used to identify the risk factors for liver fibrosis within the MASLD population. The vegetable group had significantly lower liver fibrosis indicators in the MASLD population than the rice group. The multivariate analysis identified a body mass index ≥ 25 kg/m2 (odds ratio [OR], 1.83; 95% confidence interval [CI], 1.01–1.83; p = 0.047) and HOMA-IR ≥ 1.6 (OR, 3.18; 95% CI, 1.74–5.78; p < 0.001) as risk factors for liver fibrosis, and vegetable group membership was a significant low-risk factor (OR, 0.38; 95% CI, 0.16–0.88; p = 0.023). The multivariate analysis of nutrients in low-risk foods revealed high intake of α-tocopherol (OR, 0.74; 95% CI, 0.56–0.99; p = 0.039) as a significant low-risk factor for liver fibrosis. This study suggests that a vegetable-based Japanese dietary pattern, through the antioxidant effects of α-tocopherol, may help prevent liver fibrosis in MASLD and the development of MASLD.
Anti-Neuroinflammatory Potential of Areca Nut Extract and Its Bioactive Compounds in Anthracene-Induced BV-2 Microglial Cell Activation
Authors: Janpaijit Sakawrat , Sukprasansap Monruedee , Tencomnao Tewin , Prasansuklab Anchalee
Published: August 2024

Particulate matter (PM2.5) containing polycyclic aromatic hydrocarbons (PAHs) is of considerable environmental importance worldwide due to its adverse effects on human health, which are associated with neurodegenerative diseases (NDDs). Areca catechu L. (AC) fruit is known to possess various pharmacological properties; however, the anti-neuroinflammatory roles of AC on the suppression of PAH-induced neuroinflammation are still limited. Thus, we focused on the effects and related signaling cascades of AC and its active compounds against anthracene-induced toxicity and inflammation in mouse microglial BV-2 cells. Phytochemicals in the ethanolic extract of AC (ACEE) were identified using LC-MS, and molecular docking was conducted to screen the interaction between compounds and target proteins. Significant bioactive compounds in ACEE such as arecoline, (−)-epicatechin, and syringic acid were evinced through the LC-MS spectrum. The docking study revealed that (−)-epicatechin showed the highest binding affinities against NF-κB. For cell-based approaches, anthracene induced intracellular ROS, mRNA levels of TNF-α, IL-1β, and IL-6, and the release of TNF-α through enhancing JNK, p38, and NF-κB signaling pathways. However, the co-treatment of cells with ACEE or (−)-epicatechin could reverse those anthracene-induced changes. The overall study suggested that ACEE-derived bioactive compounds such as (−)-epicatechin may be developed as a potential anti-neuroinflammatory agent by preventing inflammation-mediated NDDs.
Dietary Carbohydrates, Genetic Susceptibility, and Gout Risk: A Prospective Cohort Study in the UK
Authors: Hua Baojie , Dong Ziwei , Yang Yudan , Liu Wei , Chen Shuhui , Chen Ying , Sun Xiaohui , Ye Ding , Li Jiayu , Mao Yingying
Published: August 2024

This study aimed to investigate the associations between carbohydrate intake and gout risk, along with interactions between genetic susceptibility and carbohydrates, and the mediating roles of biomarkers. We included 187,387 participants who were free of gout at baseline and completed at least one dietary assessment in the UK Biobank. Cox proportional hazard models were used to estimate the associations between carbohydrate intake and gout risk. Over a median follow-up of 11.69 years, 2548 incident cases of gout were recorded. Total carbohydrate intake was associated with a reduced gout risk (Q4 vs. Q1: HR 0.67, 95% CI 0.60–0.74), as were total sugars (0.89, 0.80–0.99), non-free sugars (0.70, 0.63–0.78), total starch (0.70, 0.63–0.78), refined grain starch (0.85, 0.76–0.95), wholegrain starch (0.73, 0.65–0.82), and fiber (0.72, 0.64–0.80), whereas free sugars (1.15, 1.04–1.28) were associated with an increased risk. Significant additive interactions were found between total carbohydrates and genetic risk, as well as between total starch and genetic risk. Serum urate was identified as a significant mediator in all associations between carbohydrate intake (total, different types, and sources) and gout risk. In conclusion, total carbohydrate and different types and sources of carbohydrate (excluding free sugars) intake were associated with a reduced risk of gout.
Effectiveness of Family Coping Interventions in Improving Problem-Solving Skills in the Care of Children and Adolescent Cancer Survivors during and after Treatment: A Scoping Review
Authors: Prates Pedro Emílio Gomes , Correa-Júnior Antonio Jorge Silva , Russo Tatiana Mara da Silva , Paraizo-Horvath Camila Maria Silva , Teles André Aparecido da Silva , Sonobe Helena Megumi
Published: August 2024

(1) Context: Cancer triggers significant changes in family dynamics. It is noteworthy that coping and problem-solving skills, particularly in situations involving cancer in children and adolescents, have not been adequately explored in the context of family adaptation. This study aims to analyze the effectiveness of family interventions in coping to improve problem-solving skills in parents and/or caregivers of children and adolescents during and after oncological treatment. (2) Methods: This is a scoping review following the recommendations of the Joanna Briggs Institute and the Systematic Reviews and Meta-Analyses Extension for Scoping Review (PRISMA-ScR), from 2014 to 2024, in the databases LILACS, CINAHL, SCOPUS, Web of Science, and PUBMED. (3) Results: Forty-five studies were eligible. Coping strategies were categorized as follows: (1) positive attitudes (including a sense of courage and hope, family support to enhance resilience, and future planning), (2) caregiver empowerment (involving acceptance of diagnosis, emotional distancing, and coping through religiosity), and (3) communication skills (encompassing professional communication, horizontal dialogue with healthcare teams, and sincere communication with friends and family). (4) Conclusions: Over time, families develop coping and problem-solving strategies that influence changes in family functioning patterns, aiding them in accepting, reinterpreting, and reframing ideas and feelings associated with neoplasia.
Correction: Al Khatib et al. Inhaled Medicines for Targeting Non-Small Cell Lung Cancer. Pharmaceutics 2024, 15, 2777
Authors: Al Khatib Arwa Omar , El-Tanani Mohamed , Al-Obaidi Hisham
Published: August 2024

In the original publication [...]
Drug–Drug Interactions in Nosocomial Infections: An Updated Review for Clinicians
Authors: Hîncu Sorina , Apetroaei Miruna-Maria , Ștefan Gabriela , Fâcă Anca Ionela , Arsene Andreea Letiția , Mahler Beatrice , Drăgănescu Doina , Tăerel Adriana-Elena , Stancu Emilia , Hîncu Lucian , Zamfirescu Andreea , Udeanu Denisa Ioana
Published: August 2024

Prevention, assessment, and identification of drug–drug interactions (DDIs) represent a challenge for healthcare professionals, especially in nosocomial settings. This narrative review aims to provide a thorough assessment of the most clinically significant DDIs for antibiotics used in healthcare-associated infections. Complex poly-pharmaceutical regimens, targeting multiple pathogens or targeting one pathogen in the presence of another comorbidity, have an increased predisposition to result in life-threatening DDIs. Recognising, assessing, and limiting DDIs in nosocomial infections offers promising opportunities for improving health outcomes. The objective of this review is to provide clinicians with practical advice to prevent or mitigate DDIs, with the aim of increasing the safety and effectiveness of therapy. DDI management is of significant importance for individualising therapy according to the patient, disease status, and associated comorbidities.
Chili Pepper Object Detection Method Based on Improved YOLOv8n
Authors: Ma Na , Wu Yulong , Bo Yifan , Yan Hongwen
Published: August 2024

In response to the low accuracy and slow detection speed of chili recognition in natural environments, this study proposes a chili pepper object detection method based on the improved YOLOv8n. Evaluations were conducted among YOLOv5n, YOLOv6n, YOLOv7-tiny, YOLOv8n, YOLOv9, and YOLOv10 to select the optimal model. YOLOv8n was chosen as the baseline and improved as follows: (1) Replacing the YOLOv8 backbone with the improved HGNetV2 model to reduce floating-point operations and computational load during convolution. (2) Integrating the SEAM (spatially enhanced attention module) into the YOLOv8 detection head to enhance feature extraction capability under chili fruit occlusion. (3) Optimizing feature fusion using the dilated reparam block module in certain C2f (CSP bottleneck with two convolutions). (4) Substituting the traditional upsample operator with the CARAFE(content-aware reassembly of features) upsampling operator to further enhance network feature fusion capability and improve detection performance. On a custom-built chili dataset, the F0.5-score, mAP0.5, and mAP0.5:0.95 metrics improved by 1.98, 2, and 5.2 percentage points, respectively, over the original model, achieving 96.47%, 96.3%, and 79.4%. The improved model reduced parameter count and GFLOPs by 29.5% and 28.4% respectively, with a final model size of 4.6 MB. Thus, this method effectively enhances chili target detection, providing a technical foundation for intelligent chili harvesting processes.
Differential Responses of Bilberry (Vaccinium myrtillus) Phenology and Density to a Changing Environment: A Study from Western Carpathians
Authors: Kubov Martin , Fleischer Peter , Tomes Jakub , Mukarram Mohammad , Janík Rastislav , Turyasingura Benson , Fleischer Peter , Schieber Branislav
Published: August 2024

Environmental factors regulate the regeneration of mountain spruce forests, with drought, wind, and bark beetles causing the maximum damage. How these factors minimise spruce regeneration is still poorly understood. We conducted this study to investigate how the phenology and population dynamics of bilberry (Vaccinium myrtillus L.), a dominant understory species of mountain spruce forests, are related to selected environmental factors that are modified by natural disturbances (bark beetle and wind). For this, we analysed bilberry at different sites affected by bark beetles and adjacent undisturbed forests in the Tatra National Park (TANAP) during the growing season (April–September) in 2016–2021, six years after the initial bark beetle attack. The observations were taken along an altitudinal gradient (1100–1250–1400 m a.s.l.) in two habitats (disturbed spruce forest—D, undisturbed spruce forest—U). We found that habitat and altitude influenced the onset of selected phenological phases, such as the earliest onset at low altitudes (1100 m a.s.l.) in disturbed forest stands and the latest at high altitudes (1400 m a.s.l.) in undisturbed stands. Although there were non-significant differences between habitats and altitudes, likely due to local climate conditions and the absence of a tree layer, these findings suggest that bilberry can partially thrive in disturbed forest stands. Despite temperature fluctuations during early spring, the longer growing season benefits its growth.
Material Characterization of Silicones for Additive Manufacturing
Authors: Katrakova-Krüger Danka , Öchsner Simon , Ferreira Ester S. B.
Published: August 2024

Three-dimensional printing is ideally suited to produce unique and complex shapes. In this study, the material properties of polysiloxanes, commonly named silicones, produced additively by two different methods, namely, multi-jet fusion (MJF) and material extrusion (ME) with liquid printing heads, are investigated. The chemical composition was compared via Fourier-transform infrared spectroscopy, evolved gas analysis mass spectrometry, pyrolysis gas chromatography coupled to mass spectrometry, and thermogravimetry (TGA). Density and low-temperature flexibility, mechanical properties and crosslink distance via freezing point depression were measured before and after post-treatment at elevated temperatures. The results show significant differences in the chemical composition, material properties, as well as surface quality of the tested products produced by the two manufacturing routes. Chemical analysis indicates that the investigated MJF materials contain acrylate moieties, possibly isobornyl acrylate linking branches. The hardness of the MJF samples is associated with crosslinking density. In the ashes after TGA, traces of phosphorus were found, which could originate from initiators or catalysts of the curing process. The ME materials contain fillers, most probably silica, that differ in their amount. It is possible that silica also plays a role in the processing to stabilize the extrusion strand. For the harder material, a higher crosslink density was found, which was supported also by the other tested properties. The MJF samples have smooth surfaces, while the ME samples show grooved surface structures typical for the material extrusion process. Post-treatment did not improve the material properties. In the MJF samples, significant color changes were observed.
Maturity and Fruitfulness in A Song of Ice and Fire: A Reflection in Theological Anthropology
Authors: Bargár Pavol
Published: August 2024

This article seeks to understand maturity and fruitfulness in terms of going beyond oneself toward others and, ultimately, the divine Other. It suggests that, from a perspective of Christian theological anthropology, the pursuit of maturity and fruitfulness in human life entails being in community since human nature is inherently relational. To grow in maturity and “bear fruit” in one’s life, the whole web of one’s relationships at various levels must be transformed. Christian maturity and fruitfulness, then, are understood in terms of love as a non-linear striving for perfection. Ultimately, this process must be enabled and carried by grace, lest it become futile and oppressive. Using an illustrative case of A Song of Ice and Fire, a popular epic fantasy series by George R. R. Martin, this thesis will be elaborated in this article throughout three steps that make for three interrelated dimensions of this process, namely, grace, love and community, respectively.
At Which Overpass Time Do ECOSTRESS Observations Best Align with Crop Health and Water Rights?
Authors: Goffin Benjamin D. , Cortés-Monroy Carlos Calvo , Neira-Román Fernando , Gupta Diya D. , Lakshmi Venkataraman
Published: August 2024

Agroecosystems are facing the adverse effects of climate change. This study explored how the ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station (ECOSTRESS) can give new insight into irrigation allocation and plant health. Leveraging the global coverage and 70-m spatial resolution of the Evaporative Stress Index (ESI) from ECOSTRESS, we processed over 200 overpasses and examined patterns over 3 growing seasons across the Maipo River Basin of Central Chile, which faces exacerbated water stress. We found that ECOSTRESS ESI varies substantially based on the overpass time, with ESI values being systematically higher in the morning and lower in the afternoon. We also compared variations in ESI against spatial patterns in the environment. To that end, we analyzed the vegetation greenness sensed from Landsat 8 and compiled the referential irrigation allocation from Chilean water regulators. Consistently, we found stronger correlations between these variables and ESI in the morning time (than in the afternoon). Based on our findings, we discussed new insights and potential applications of ECOSTRESS ESI in support of improved agricultural monitoring and sustainable water management.
Identification and Deformation Characteristics of Active Landslides at Large Hydropower Stations at the Early Impoundment Stage: A Case Study of the Lianghekou Reservoir Area in Sichuan Province, Southwest China
Authors: Li Xueqing , Li Weile , Wu Zhanglei , Xu Qiang , Zheng Da , Dong Xiujun , Lu Huiyan , Shan Yunfeng , Zhou Shengsen , Yu Wenlong , Wang Xincheng
Published: August 2024

Reservoir impoundment imposes a significant triggering effect on bank landslides. Studying the early identification of landslides and their stability concerning reservoir water levels and rainfall is vital for guaranteeing the safety of residents and infrastructure in reservoir regions. This study proposed a method for establishing a dynamic inventory of active landslides at large hydropower stations using integrated remote sensing techniques, demonstrated at Lianghekou Reservoir. We employed interferometric stacking synthetic aperture radar (stacking-InSAR) technology, small baseline subset interferometric synthetic aperture radar (SBAS-InSAR) technology, and optical satellite images to identify and catalogue active landslides. Moreover, we conducted field investigations to examine the deformation characteristics of landslides. Finally, Pearson’s correlation analysis was employed to evaluate the response between deformation values, reservoir water levels, and rainfall. The results revealed 75 active landslides, including 12 long-term active landslides before impoundment and 63 new landslides after impoundment, which were primarily concentrated in the Waduo and Yazho–Zatou regions. The correlation coefficient between landslide deformation values and the reservoir level was high (0.93), while the correlation coefficient with rainfall was low (0.57). The results of this research offer a crucial foundation for preventing and mitigating landslides in reservoir areas.
Large-Scale Mapping of Complex Forest Typologies Using Multispectral Imagery and Low-Density Airborne LiDAR: A Case Study in Pinsapo Fir Forests
Authors: Ariza-Salamanca Antonio Jesús , González-Moreno Pablo , López-Quintanilla José Benedicto , Navarro-Cerrillo Rafael María
Published: August 2024

Climate change increases the vulnerability of relict forests. To address this problem, regional Forest Services require silvicultural and conservation actions to designate specific forest management alternatives. In this context, the main objective of this study was to develop a methodology to map complex Abies pinsapo forest typologies using multispectral and low-density airborne LiDAR data and machine learning. Stand density, species composition and cover were used to identify seven forest typologies. Random forest resulted as the more accurate model (OA = 0.62; Kappa = 0.43) to classify those types based on multispectral and LiDAR data, although showing a moderate model performance. Classification performance showed great differences between forest types with better results for the uneven-aged stands compared to the even-aged and two-aged stands. The developed typology was applied to supply local forest managers with more accurate forest maps that can be used to improve forest management plans. The typology proposed is easy to apply in forest management practices since it only uses as input the diameter at breast height, tree density and specific composition. The study demonstrated the potential of low-density LiDAR data combined with spectral information from high-resolution orthophotos to predict the structural characteristics of complex forest typologies.
Border Tensions for Rethinking Communication and Development: A Case of Building History in Ticoya Resguardo
Authors: Herrera-Huérfano Eliana , Ochoa-Almanza Juana , Fayad Sanz David
Published: August 2024

This article proposes rethinking communication, development, and social change from a decolonial perspective through the case study of the Ticoya resguardo. It examines how the oral traditions of Indigenous elders construct a history of the territory, positioning orality as a practice of communicative and cognitive justice that transcends the dominant structures of the nation-state. Border tensions are explored both as a physical reality between Colombia and Peru and as a metaphor for identity conflicts. The theoretical framework incorporates debates on post-development, pluriverse, and southern epistemologies, challenging social inequalities. A qualitative methodology based on the praxeological method was implemented in four stages in collaboration with the resguardo’s communications committee. Producing a radio series narrated by participants was crucial for gathering the elders’ narratives through conversations, social mapping, and storytelling. The findings emphasize the break with linear temporality in narratives, the sense of territory beyond state borders, and the identity tensions of river dwellers. The conclusion underscores the necessity of a decolonial perspective, recognizing the impact of monocultures in obscuring diverse forms of life. The Ticoya resguardo case illustrates how communicative justice can highlight the local and everyday, considering the territory essential in the pluriverse, aligning with Escobar’s and Santos’ proposals on transitions toward a pluriversal world.