bluuebunny/crossref_metadata_2025 huggingface dataset:
Genesis and controlling factors of Cenozoic dolostones in the South China Sea: A case study from core Nanke-1 in the Nansha Islands
Authors: Zhou Mo , Wu Feng , Xie Xinong , Yan Wen
Published: May 2023

The "dolomite problem", the origin of dolomite in natural environment, remains controversial after being a topic of debate in geology for more than two century. In the South China Sea (SCS), the dolostone widely occurs in the Cenozoic reef-bearing successions. Based on mineralogical and geochemical data from the Nanke-1 core at Meiji Reef, Nansha Islands, the processes of dolomitization and its associated diagenesis are investigated in this study. The Neogene dolomites in the Nanke-1 core exist in two forms: microsucrosic and mimetic dolomites. Microsucrosic dolomite is commonly characterized by high calcium content (HCD) and shows the larger crystal size with partial iron stains. In contrast, the mol% Ca content is more depeleted in the mimetic fabric with the smaller size of rhombs. The Upper Miocene dolostone is dominantly composed of thick-layered microsucrosic dolomite, while the Pliocene dolostone is mainly composed of mimetic dolomite. The discrepancy of petrographic occurrence between two types of dolomite rhombs is most attributed to the porosity and Mg/Ca ratio of the parent dolomitizing fluid. During the Late Miocene, the global sea level was generally low, and the platform top was flooded mainly during the highstands, allowing the formation of coarse sediments with abundant primary pores in the shallow-water setting. These platform top carbonates were exposed and experienced meteoric dissolutions during the subsequent sea level falls, favoring the development of secondary pores. The above processes may cause the Upper Miocene strata porous. The higher porosity in the Upper Miocene stratum facilitated more extensive diagenetic alteration, leading to the production of microsucrosic dolomite. In contrast, during the Pliocene, the rising sea-level and the resultant fine-grain sediments may provide a relatively restricted diagenetic environment which produces the mimetic fabric in the dolostone. The gradual rise in seawater Mg/Ca ratio from the Late Miocene to the Pliocene led to the preferential formation of HCD in the Upper Miocene stratum. Additionally, the development of Neogene dolostone in the SCS was synchronous with the dolomitization events elsewhere, which hints that these dolostones could be controlled by similar triggers. The dolomitization mechanisms at core Nanke-1 discussed herein can benefit further explanation for the Cenozoic dolomitization events in other regions worldwide.
Generalization of dynamic Hilbert-Pachpatte inequality via Taylor formula on time scale
Authors: El-Owaidy Hassan M. , Mohamed Karim A. , El-Deeb Ahmed A. , Rezk H. M.
Published: May 2023

It is our purpose of this paper to obtain an extension of integral inequality of Hilbert-type on time scales. Our results will be proved by using some algebraic inequalities, Taylor's theorem, Young's inequality, Hölder's inequality, and integration by parts on time scales.
Mathematics Subject Classification (2020): 26A15, 26D10, 26D15, 39A13, 34A40, 34N05.
Ecological Niche Modelling and Density of Sings as Conservation Tools of Taxidea Taxus Berlandieri in Central – Northern Mexico
Authors: Palacio-Núñez Jorge , Martínez-Calderas Jesús Manuel , Rössel-Ramírez David Walter , Martínez-Montoya Juan Felipe , Clemente-Sánchez Fernando , Olmos-Oropeza Genaro
Published: May 2023

The American badger o tlalcoyote (Taxidea taxus berlandieri) is a subspecies inhabits in north-central Mexico; its population and conservation status are unknown and there is no precise information about its habitat. The objectives of our study were to model the ecological niche suitability for T. t. berlandieri, to estimate the population density by signs km-2 and to identify the habitat variables that contribute to their occurrence in north-central Mexico. We modeled ecological niche using MaxEnt and KUENM, with 13 predictor variables, and 43 occurrence records obtained from 177 sites sampled between the total or partial extension of nine physiographic subprovinces; on 5 states in the north-central region of Mexico. Our model showed a high suitability probability (P > 0.75) in Llanuras y Sierras Postosino - Zacatecanas, Sierras Transversales and Sierras y Lomeríos de Aldama y Río Grande; in parts of the states of Durango, San Luis Potosí, and Zacatecas. The variables with the highest contribution to occurrence probability were slope (plains and plateaus), topography (from flat to undulating), and types of vegetation (dominated by scrub). With the records, we estimated an average density of 0.019 signs km-2 for tlalcoyote in the total extension of the study area. According to our findings, it is possible that the population status of T. t. berlandieri, as a subspecies, is below desirable density levels and its suitable ecological niche its limited. Therefore, we argued to focus more studies on conservation for this subspecies, using these results as basis for delimiting its distribution area.
A computational study of two promising tweezers
Authors: Sayaheen Mohammad , Otero Nicolás , Peña-Gallego Angeles
Published: May 2023

A DFT study was carried out to explore the properties of two nonplanar π-conjugated systems that share dibenzo[a,e]-cyclooctatetraene (DBCOT) as a fundamental element. These systems were presented as molecules with potential use as tweezers and in optoelectronic applications due to their expected nonlinear optical (NLO) effects. Structure optimizations, TD-DFT calculations, and molecular orbitals and topological analysis were performed for both structures with and without the Na cation. This alkali cation was used as a model to investigate the potential of these molecules as tweezers. The results show a V-shaped structure as a minimum in the ground state for both molecules. This angular structure can trap the Na cation very effectively, especially for one of the cases. In addition, the present analysis opens new studies to explore the use of these systems as tweezers of other cations, anions or aromatic molecules that may exhibit π-stacking. The analysis of the molecular orbitals involved in the main electronic transitions allows us to propose that these systems will have interesting optical properties, proposing the inclusion of functional groups to modulate the optical respònse.
Analyzing the extracellular matrix-dominated immune landscape of high-grade serous ovarian cancer to determine prognosis and guide therapy
Authors: Wu Qihui , He Xiaoyun , Liu Jiaxin , Ou Chunlin , Li Yinmin , fu xiaodan
Published: May 2023

High grade serous ovarian cancer (HGSOC) is associated with a poor prognosis and a high recurrence rate. For high-risk patients, personalized treatment augmentation and clinically relevant molecular prognostic indicators are required. As extracellular matrix (ECM) are very active component of the tumor microenvironment, influencing the behavior and metastatic potential of tumor cells, understanding ECM function may aid in the development of useful diagnostics and innovative medicines for HGSOC. Using univariate Cox regression analysis, we identified 71 ECM genes associated with prognosis in seven HGSOC populations. Cox proportional hazards regression with lasso penalty was utilized to validate the ECMscore signature of 14 genes. Analyses of Cox regression indicate that ECMscore is an excellent indication for prognostic classification in the most prevalent malignancies, including HGSOC. In addition, we found that patients with a higher ECMscore exhibited more active stromal and carcinogenic activation pathways, including apical Surface, Notch signaling, apical Junction, Wnt signaling, epithelial-mesenchymal transition, TGF-ß signaling, and angiogenesis. In contrast, patients with a relatively low ECMscore had more active immune-related pathways, such as interferon alpha response, interferon-gamma response, and inflammatory response. The relationship between the ECMscore and genome anomalies was further examined. In addition, the interaction between ECMscore and immune microenvironment components and signals in HGSOC was examined in greater detail. As one of the hubs, the expression of MGP and its relationship to FBN1 were validated using qRT-PCR on HGSOC samples. The utility of ECMscore in predicting the prospective clinical success of immunotherapy and its capacity to guide the selection of chemotherapeutic medicines were also investigated. Additionally, pan-cancer research showed similar results. In conclusion, a comprehensive evaluation of the ECM may enable the identification of immune activation and help patients in HGSOC and pan-cancer to obtain the proper therapy.
Next-Generation OBS Architecture Transforms 5G Networks Powered by Machine Learning, Probabilistic Modeling and Algorithm Optimisation
Authors: Garg Amit Kumar
Published: May 2023

Next-generation 5G networks require a high-speed, low-latency, and robust communication backbone to support new applications such as IoT, cloud computing, and virtual reality. Optical burst switching (OBS) is a promising method for 5G networks due to its ability to handle high-speed data transit and excellent bandwidth utilisation. Traditional OBS networks, on the other hand, have a high blocking probability, low resource utilisation, and limited scalability. To address these challenges, this work provides a unique OBS design that integrates machine learning, probabilistic modelling, and efficient algorithms. The usage of machine learning-based burst assembly algorithms, which dynamically predict the best resource allocation for each burst based on network conditions and QoS requirements, is a key component of the proposed architecture. A complete simulation analysis is performed using a typical Wavelength Division Multiplexing (WDM) traffic dataset to evaluate the performance of the proposed architecture. The simulation results show that, as compared to standard OBS networks, the suggested architecture reduces the likelihood of obstruction and improves resource utilisation significantly. Furthermore, when compared to previous OBS systems, the suggested design is more efficient at managing dynamic traffic and enables greater scalability. The simulation study's performance tests demonstrate that the suggested architecture has a blocking probability of less than 10− 6, a throughput of more than 95%, and a latency of less than 4 milliseconds. These findings show that the suggested OBS design for next-generation 5G networks is both feasible and effective.
Enhanced electrochemical properties of nanostructured Bi0.9Gd0.1FeO3 thin film as electrode material for super capacitors
Authors: R Anlin Golda , R Anlin Golda , Alex E. John , Manju B. Gayathri
Published: May 2023

Nanostructured gadolinium doped bismuth ferrite thin film (Bi0.9Gd0.1FeO3) as electrode material for supercapacitors was investigated. Specific capacitance of 812F/g has been observed through electrochemical measurements. Gadolinium doped bismuth ferrite was synthesized using solgel method and was deposited on Si/SiO2/TiO2/Pt substrate through spin coating. XRD measurements exhibited rhombohedrally distorted perovskite structure. The presence of nanorods was identified through SEM and AFM, and the nanorods average thickness was measured to be around 200nm. The functional groups were confirmed through the FTIR spectrum. The cyclic voltammetry and electrochemical impedance spectroscopy was carried out to study its capacitive performance in liquid environment for its use in supercapacitors. Based on the results, gadolinium doped bismuth ferrite thin films are found to be a potential electrode material for supercapacitors.
Hydrolysis and condensation behavior of tetraethoxysilane, hexaethoxydisiloxane, and octaethoxytrisiloxane
Authors: Sato Yohei , Sugimoto Asahi , Iwashina Tatsuya , Hayami Ryohei , Yamamoto Kazuki , Gunji Takahiro
Published: May 2023

In the initial stage of the hydrolysis–condensation of tetraethoxysilane (TEOS), hexaethoxydisiloxane (HEDS) and octaethoxytrisiloxane (OETS) are formed. However, little is known about the hydrolysis–condensation of HEDS and OETS. In this study, the hydrolysis–condensation of TEOS, HEDS, and OETS was investigated. HEDS and OETS were synthesized from diethoxy(diisocyanato)silane, a raw material with controllable functionality. The hydrolysis of TEOS, HEDS, and OETS was analyzed by mass spectroscopy, gel permeation chromatography, and nuclear magnetic resonance. The hydrolysis–condensation product of TEOS was a three-dimensional network-type polysiloxane. The hydrolysis–condensationproduct of HEDS consisted mainly of four-membered cyclic siloxane. The hydrolysis–condensation product of OETS consisted mainly of various membered cyclic siloxanes.
Moisture Distribution in Cross Laminated Timber (CLT) Made from Heat Treated Wood
Authors: Mohebby Behboood , Broushakian Vahid
Published: May 2023

Cross-laminated timber (CLT) panels are recognized as an engineered building product worldwide and, given that they are made from solid wood, they can absorb moisture from or emit moisture to their surrounding environment when placed in either wet or dry conditions. This absorption and desorption processes creates a moisture gradient in the wood material, causing stress. This study investigates the moisture distribution and gradients in the CLT panels made from fir wood layers that have been heat-treated at 170°C. The panels were subjected to wet-dry cycles (from relative humidity of 88% to 32% and then from 32% to 88%). The paired heat-treated CLT panels showed less moisture and more uniform moisture compared to the untreated panels, with a less uniform moisture distribution and different moisture pockets. The moisture gradients between the treated and untreated the CLT panels indicated that heat-treatment affected the moisture gradient change. The treated panels had lower moisture gradients than the untreated panels.
An Efficient Healthcare Monitoring System for Cardiovascular Diseases using Deep Modified Neural Networks
Authors: Reddy C Kishor Kumar , pujala nishitha
Published: May 2023

Doctors check medical records to figure out the chances of someone getting heart disease (Myocardial infarction). Major focus will be on blood pressure, how old the person is, if he is a man or a woman, if they feel pain in their chest, how much is their cholesterol level, and how much sugar is in their blood. However, manual illustrations may lead to incorrect predictions. The expectation of heart malady may be a key issue within the investigation of clinical dataset. The point of the proposed examination is to recognize the key characteristics of heart infection expectation utilizing profound learning methods. Numerous ponders have centered on heart infection conclusion, but the execution of the discoveries is moo. In this manner, to progress forecast precision, an profound learning system for the determination of heart illness utilizing adjusted Deep Neural Networks (DNN) is proposed by using Cleveland database by adjusting its learning parameters. The proposed method used has a score of 90.7, with a higher precision of 91.5 compared to other methods.
Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors
Authors: Llinàs-Arias Pere , Orozco Javier IJ , Ensenyat-Mendez Miquel , Íñiguez-Muñoz Sandra , Valdez Betsy , Salomon Matthew P. , Matsuba Chikako , Sesé Borja , Mezger Anja , Ormestad Mattias , Hwang E Shelley , Cortés Javier , DiNome Maggie L. , Esteller Manel , Boiko Alexander , Lupien Mathieu , Marzese Diego
Published: May 2023

Background Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome may contribute to matrix metalloprotease (MMP) dysregulation given their key role in invasion, which is the first step of the metastatic process.Methods We combined RNA expression and chromatin interaction data to identify insulator elements potentially associated with invasion. We stably disrupted the CCCTC-Binding Factor (CTCF) binding site of a single insulator element in two TNBC cellular models. We characterized these models by combining Hi-C, ATAC-seq, and RNA-seq with functional experiments to determine invasive ability. Our findings were then also tested in a ductal carcinoma in situ (DCIS) cohort.Results We explored the clinical relevance of an insulator element located within the Chr11q22.2 locus, downstream of the MMP8 gene (IE8). This regulatory element resulted in a topologically associating domain (TAD) boundary that isolated nine MMP genes into two anti-correlated expression clusters. This expression pattern was strongly associated with worse relapse-free (HR = 1.57 [1.06 − 2.33]; p = 0.023) and overall (HR = 2.65 [1.31 − 5.37], p = 0.005) survival of TNBC patients. After CRISPR/Cas9-mediated disruption of IE8, cancer cells showed a switch in the MMP expression signature, specifically downregulating the pro-invasive MMP1 gene and upregulating the antitumorigenic MMP8 gene, resulting in reduced invasive ability. Finally, we observed that the imbalance in the MMP expression predicts DCIS that eventually progresses into invasive ductal carcinomas (AUC = 0.77, p < 0.01).Conclusion Our study demonstrates how the activation of an IE near the MMP8 gene determines the regional transcriptional regulation of MMP genes with opposing functional activity, ultimately influencing the invasive properties of aggressive forms of breast cancer.
Basic schools’ closure and review of educators' remote teaching experiences and challenges in South Africa public schools
Authors: Ahiaku Philip Kwashi Atiso , Akintolu Morakinyo
Published: May 2023

The object of research: This paper looks to address the effectiveness of remote teaching during the lockdown.

Investigated problem: Education during the COVID-19 pandemic was affected remarkably due to the lockdown in most countries including South Africa.

The main scientific results: The paper highlights failures in the planning, management, and organization of remote teaching during the lockdown.

The area of practical use of the research results: The paper employs a mixed method approach to study the experiences of teachers and the challenges they faced during and after the lockdown. One hundred and forty-four (144) Life Sciences teachers responded to a survey using questionnaires, and another fifteen (15) took part in telephonic interview(s) that followed an interview schedule.

Innovative technological product: Based on these findings, the paper suggests that the government should invest in and ensure the availability of reliable communication tools, high quality internet connectivity, and actively promote the development of digital academic skills for both teachers and learners. Let’s also suggest numerous steps that must be taken to develop a curriculum that reflects not only the perceptible change(s) in content knowledge, but also the learning experiences of teachers and learners.

Scope of the innovative product: The respondents were Life Sciences educators from public high schools in Mpumalanga province in South Africa
The concepts of ‘Zulu tribe’ and ‘Zulu nation’ and their use towards political aspirations in South Africa
Authors: Mbatha Mthandeni Patric , Cebekhulu Mxolisi Bongumusa PraseGod
Published: May 2023

The object of research: This article presents an overview of how the concept of tribe and nation has been manipulated for political end. The first part of the paper clearly establishes that the two concepts are not only different but also represent different epochs in Zulu history.

Investigated problem: this article interrogates this neglected subject by focusing on how Europeans used different terms to denegrate Africans during colonialism. The main objective is to reveal social agency, showing that the African ethnic groups were also capable of making nations before the arrival of colonialism.

The main scientific results: The findings of this paper indicated that the concepts ‘tribe’ and ‘nation’ present different epochs in Zulu history therefore using them interchangeably as if they refer to one thing is politically incorrect. Moreover, findings indicated that there is nothing wrong with the words as they are defined by dictionaries but the way in which they were used created confusion.

Innovative product: The result of this study will be incorporated in our history curriculum, which specifically focuses at how the process of colonization affected the Zulu monarchy.

The area of practical use of the research results: The study is of importance to South African historians and those who are interested to study the transition of AmaZulu from a tribe to a nation.
Developing a methodological approach to assessing state information security
Authors: Andriishena Halyna , Chunakov Roman , Zaitsev Mykola , Shyshatskyi Andrii
Published: May 2023

The object of the research is the system of information security of the state.

Investigated problem: The experience of operations (combat operations) of recent years shows the growing role of information influence measures on the systems of collection, processing and transmission of special purpose information and decision-making officials.

The specificity of measures to ensure the information security of the state is that, on the one hand, it is necessary to solve the task of collecting, processing and transmitting information, and on the other hand, it is necessary to counteract measures of information influence on the systems of collecting, processing and transmitting information and decision-making officials.

Given this, information attacks have become a real threat and are one of the priority problems of national security and risk management. Information security covers all security measures that can be taken to protect against these impacts. A significant increase in the complexity and intensity of information attacks in recent years has forced most developed countries to strengthen their defenses and adopt national information security strategies.

The area of practical use of the research results: It is advisable to use the proposed scientific results when conducting research and development works on the creation of intelligent systems for collecting, processing and analyzing information about the state of information security of the state, and developing requirements for hardware and software of this type of systems.

Field of application: software, information systems, decision support systems.
Development of technology for the production of sweet products based on melon fruit
Authors: Alimardanova Mariam , Tlevlessova Dinara , Petrenko Elena , Brindyukova Alexandra
Published: May 2023

Object of research: the process of creating a technology for the preparation of sweet products using locally produced melon fruits.

Investigated goal: Development of technology for the production of sweet products from gourds on a natural basis using local unsold raw materials.

Main scientific results: possible ways of using unsold melon fruits in the food industry were identified, a solution to the problem of overproduction of melons and gourds in the country was proposed. The original technologies for the production of sweet products made on the basis of the fruits of gourds have been compiled and worked out. the evaluation of the nutritional value of finished products was carried out.

Area of practical use of research results: small and medium-sized farms for the production of melon fruits.

Innovative technological product: technology for the production of sweet products, which allows organizing the industrial processing of the unsold volume of gourds.

Scope of the innovative technological product: agricultural and food industry in the field of melons processing, small and medium enterprises for the production of melons, confectionery production.
Experiencias en restauracion ambiental, Caso: Mollepata – Pongora, distritos de Ayacucho y Jesus Nazareno, Region de Ayacucho Perú
Authors: Suclli Efrain
Published: May 2023

La noción de restauración del medio natural comprende la recuperación de un ecosistema intervenido por acción antrópica, afectado o transformado en su composición y estructura básica como la cobertura vegetal. El presente estudio recoge las experiencias de caso en el proceso de restauración ambiental en el marco de ejecución del proyecto “Mejoramiento y Ampliación del Servicio de Transitabilidad Tramo Emp. Ay – 780 Mollepata – Em. Pe 3s Pongora en los distritos de Ayacucho y Jesús Nazareno de la Provincia de Huamanga – Departamento de Ayacucho” a cargo del Gobierno Regional Ayacucho, gestión 2023-2027. El objetivo del proceso se centra en el tratamiento de los depósitos de material excedente (DEMs) a partir de la restauración ambiental suscrito en el art. 65° del reglamento de protección ambiental para el sector transportes D.S. 004-2017-MTC; tal fin conllevó a la caracterización del medio natural: cobertura vegetal y el medio físico circunscrito en un recorrido de 08 kilómetros, acondicionamiento de taludes mediante su estabilización con muros de contención, perfilado para revegetación y tratamiento de la escorrentía superficial por sistema de drenes.
Acehnese Loanwords and Contact with Other World's Languages
Authors: Akmal Saiful , Harley Lala Barzanzia , Rahmikawati Rahmikawati , Maulida Titin Arifa
Published: May 2023

The research aimed to uncover some Acehnese loanwords’ etymological and historical roots, which may help unravel the relationships between the world’s languages. The method applied in the research was the word-etymology model or lexical etymology to trace the word’s origins in historical linguistics. In addition, the systematic comparison with other related languages and semantic change typology were also exercised for the purpose of analysis. The data consisted of some selected Acehnese loanwords from the phone interviews with the participants selected purposively in different districts in Aceh. The findings reveal that the Acehnese language is etymologically categorized as part of the Austronesian language (Chamic and Malay), Arabic Afro-Asiatic language, Sanskrit (Bengali, Urdu, Gujarat), English, and Indo-European. The research attests that Acehnese loanwords may also be influenced by cross-language loanwords and borrowings simultaneously, such as Arabic from the Afro-Asiatic language family, Dutch or German, and English from the Indo-European language.
Role Playing Game (RPG ) Video Games and Loneliness: An Analysis of Finding Paradise Narrative
Authors: Saraswati Listya Ayu , Rifai Irfan , Farhan Muhamad
Published: May 2023

The research argued that ‘Finding Paradise’, the third installment of adventure RPG video games developed and published by Freebird Games, embodied excellent storytelling techniques for illustrating loneliness and those who experienced it in society. The ‘Finding Paradise’ narrative used immersive technology to let players experience the subject at hand with their own senses. Video game design aimed for relevancy to contemporary society’s realities as well as compelling storytelling. Close reading was used to break down ‘Finding Paradise’ narratives into smaller aspects to strengthen and articulate a more connected relationship with the text; as a result, the researchers could draw interpretations within the text. By incorporating Herman’s fundamental narrative components into the ‘Finding Paradise’ narrative and examining how stories and narratives can be used as a teaching tool using the reader-response approach, it can be concluded that the subcomponents of the game’s narrative, specifically the representation of situatedness, event sequencing, worldmaking, and reality representation, provide a good example of developing a well-crafted and non-judgmental representation of loneliness as a mental illness and individuals who suffer from it that can also be used in EFL/ESL classroom.
Using FlipGrid to Improve Memory Ability in Learning Foreign Languages
Authors: Chandra Mei Rianto
Published: May 2023

The research showed that online media was expected to provide a more straightforward understanding to students in learning Mandarin, one of which was FlipGrid online learning media. Learning Mandarin was quite challenging if it was only done by using textbooks. This could be shown by the lack of students’ memory of the vocabulary they had just learned. The data were analyzed with a quantitative approach involving 110 students aged 13 to 14. The data was collected of students’ vocabulary study after two months of using three test questions: filling in the blanks, guessing the meaning, and completing sentences. Thus, it can be concluded that understanding the vocabulary learned on the FlipGrid platform media can also be an additional vocabulary for students in developing speaking skills. The results reveal that the teacher’s participation in monitoring the completion of students’ assignments also plays a vital role in developing students’ speaking skills, which means that the frequency of using FlipGrid directly impacts students’ memory skills. However, when faced with critical thinking test questions, students themselves must be able to think out of the box and not only based on what they have learned from FlipGrid online. That means the research implies a need for a more innovative instructional design for language learning to improve better students’ memorization to learn Mandarin.
The Importance of Brand Stories towards Brand Perception and Purchase Intention in Gen Z Indonesians
Authors: Andhini Grasheli Kusuma , Andanawarih Fauzia Qurani
Published: May 2023

The research explored the importance of brand story towards Indonesia’s Gen Z and how it affected buying decisions and perception towards the brand. It explored if creating a brand story is a central element in creating and differentiating Indonesian fashion brands that becomes a beneficial tool for both business owner and its customer. The research was conducted through an exploratory descriptive approach by using survey on Indonesian collectivist society—those who behave communally based on in-group norms including the 84 Gen Z—as well as archival research on two similar fashion brands, and interviews on one customer and one brand owner. The research findings point out that brand stories take a positive effect on a customer’s perception towards a brand and their purchase decision. While brand stories do have an influence in shaping the image of a brand as well as becoming a factor in a customer’s purchase decision process, other brand attributes such as packaging, social media content, and logos also plays an important role in a shaping brand image, as well as the customer’s final purchase decision. Furthermore, the opinions of a key opinion leader about a brand or product greatly matters in this society and that people are more willing to purchase a product if it has already been positively reviewed by a key opinion leader.
Social Capital in Family Firms: Impacts on Family-Longevity-Goals and Performances
Authors: Kurniawan Daniel , Ardyan Elia , Istiatin Istiatin , Luhgianto Luhgianto
Published: May 2023

The research was motivated to examine the impact of family, specifically in social capital on firm performances during the COVID-19 pandemic. The research used a quantitative approach and will be analysed by both descriptive and inferential statistics by obtaining questionnaires from the 89 research subjects with a Likert scale to create a whole picture of the social capital dimensions of 89 family firms and their family longevity goals (FLG) as well as their firm performances (FP). The research finds that social capital dimensions have a significant and positive impact on both family longevity goals and firm performance. Moreover, it is found that family longevity goals mediate the positive relationship between social capital dimensions and firm performances. It is also revealed that the impact of social capital dimensions is stronger in firms controlled by the second generation. It is suggested that future research include the external side of the social capital to have further understanding on its impact towards the performance of family business.
Sustentabilidade organizacional:
Authors: Muniz Camila , Zanelato Pantaleão Carlos Henrique , Silveira dos Santos Manoela
Published: May 2023

Esta pesquisa teve por objetivo propor um modelo para autoavaliação da sustentabilidade econômica como um instrumento gerencial de apoio à decisão aplicada à uma empresa de pequeno porte do ramo de serviços automotivos no município de Foz do Iguaçu – PR. A necessidade de aprimorar as análises gerenciais de modo a dialogar com o desenvolvimento sustentável, faz-se necessário novas formas de gestão para as empresas serem mais competitivas. A empresa pesquisada tem a sustentabilidade como um pilar estratégico, mas não se utiliza um modelo de autoavaliação capaz de avaliar seu desempenho nesta seara. A metodologia utilizada foi a análise multicritério construtivista (MCDA-C) associando a abordagem do triple bottom line (Elkington, 1999) e indicadores econômicos do Global Reporting Initiative (GRI, 2018). Para a aplicação e análises, realizou-se entrevistas e aplicação de questionário junto aos atores participantes do processo. Os resultados em relação à construção e aplicação do modelo proposto se mostraram eficazes e possíveis de se tornar um meio adequado para avaliação da sustentabilidade econômica fornecendo dados que apoiam as decisões gerenciais. Como resultado da avaliação, a empresa apresentou um desempenho econômico com grande potencial para se tornar mais sustentável, obtendo insights importantes que podem gerar ações ao planejamento estratégico empresarial em busca de melhorias contínuas a fim de se adequar e aprimorar, constantemente, suas operações em prol do desenvolvimento sustentável.
Fraudes empresariales de mayor ocurrencia en el sector cooperativo
Authors: Hernandez Aros Ludivia , Carvajal Carvajal Daniela , González Huertas Luisa Fernanda , Otavo Perdomo Kely Johana
Published: May 2023

El sector cooperativo se ve enfrentado a amenazas frecuentes de fraudes empresariales, donde es urgente minimizar riesgos e implementar controles, que otorguen tranquilidad a los diferentes stakeholders que serían afectados al ser materializado un fraude. Frente a esta realidad, el estudio analiza los fraudes empresariales de mayor ocurrencia en el sector cooperativo. A nivel procedimental, se contempla en el documento los estudios anteriores del fraude empresarial y sus características, para luego detallar variables y riesgos de control, inherentes, de detección, entre otros, determinando los desafíos que tiene el sector cooperativo para la prevención y detección temprana de fraudes, y se exponen algunos casos de estudio encontrados en la literatura. Como resultado se observa que el sector cooperativo está expuesto a toda clase de fraudes y para ello, se implementan herramientas tradicionales y especializadas en detección temprana, además la literatura señala que uno de los fraudes de mayor incidencia en estas organizaciones e el fraude laboral, donde variables como las del pentágono de fraude (presión, oportunidad, capacidad, racionalización, motivación y oportunidad) son aprovechadas por los empleadores o empleados, situación que se observa desde el nivel interno de la cooperativa.
Utilização da técnica de GPR (Ground Penetrating Radar) para a caracterização do Maciço Vitória (Espírito Santo, Sudeste do Brasil)
Authors: Silva da Rocha Diego , Leonardi Bricalli Luiza , José Moreira Pires Patricio
Published: May 2023

Este estudo tem como objetivo caracterizar, através de método eletromagnético, a unidade geológica Maciço Vitória na região metropolitana de Vitória-ES, utilizando a técnica de GPR- Ground Penetrating Radar. Objetivos secundários visam investigar litotipos e estruturas geológicas, delimitar contatos entre aterros e embasamento Pré-Cambriano, investigar e descrever arranjos de estruturas geológicas e demonstrar a assinatura geofísica das unidades estudadas. A área de estudo corresponde a área do Parque Pedra da Cebola, que pertence a unidade Maciço Vitória, por sua vez a unidade fica localizada em Vitória, capital do Espírito Santo. Foram realizados 4 (quatro) perfis geofísicos, em diferentes orientações, de forma que as diferentes características de subsuperfície fossem abordadas e representadas no radargrama. A aquisição de GPR foi realizada com antena de 270 MHz (duzentos e setenta megahertz), o caminhamento foi realizado utilizando o método do afastamento constante onde as antenas permanecem a uma distância constante uma da outra. Os perfis de GPR foram processados através do programa RADAN7®, utilizando processamento avançado de dados até que a imagem obtida apresentasse refletores e anomalias bem demarcados. Os dados dos radargramas mostraram dois aspectos geológicos importantes: limite de unidades geológicas bastante delimitados e presença de estruturas geológicas. Foram encontras falhas e fraturas de direção NE-SW e secundariamente NNW-SSE e E-W, essas estruturas correspondem ao trend regional. Essas estruturas podem estar associadas a controles litoestruturais e tensões neotectônicas. O método demonstrou uma fácil e rápida aplicação, destacando-se aqui uma otimização de tempo e custo para análise de material em subsuperfície.
Palavras-chave: Ground Penetrating Radar; Fraturamento; Geofísica.
B2M is a Biomarker Associated With Immune Infiltration In High Altitude Pulmonary Edema
Authors: Yuan Mu , Hu Xueting , Xing Wei , Wu Xiaofeng , Pu Chengxiu , Guo Wei , Zhu Xiyan , Yao Mengwei , Ao Luoquan , Li Zhan , Xu Xiang
Published: May 2023

Background:

High altitude pulmonary edema (HAPE) is a serious mountain sickness
with certain mortality. Its early diagnosis is very important. However, the mechanism of its onset
and progression is still controversial.

Aim:

This study aimed to analyze the HAPE occurrence and development mechanism and search
for prospective biomarkers in peripheral blood.

Methods:

The difference genes (DEGs) of the Control group and the HAPE group were enriched
by gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis,
and then GSEA analysis was performed. After identifying the immune-related hub genes, QPCR
was used to verify and analyze the hub gene function and diagnostic value with single-gene GSEA
and ROC curves, and the drugs that acted on the hub gene was found in the CTD database.
Immune infiltration and its association with the hub genes were analyzed using CIBERSORT.
Finally, WGCNA was employed to investigate immune invasion cells' significantly related
gene modules, following enrichment analysis of their GO and KEGG.

Results:

The dataset enrichment analysis, immune invasion analysis and WGCNA analysis showed that the occurrence and early progression of HAPE were unrelated to inflammation. The hub genes associated with immunity obtained with MCODE algorithm of Cytoscape were JAK2 and B2M. RT-qPCR and ROC curves confirmed that the hub gene B2M was a specific biomarker of HAPE and had diagnostic value, and single-gene GSEA analysis confirmed that it participated in MHC I molecule-mediated antigen presentation ability decreased, resulting in reduced immunity.

Conclusion:

Occurrence and early progression of high altitude pulmonary edema may not be related
to inflammation. B2M may be a new clinical potential biomarker for HAPE for early diagnosis
and therapeutic evaluation as well as therapeutic targets, and its decrease may be related to reduced
immunity due to reduced ability of MCH I to participate in antigen submission.
Comparative Pharmacokinetics of Scoparone and its Metabolite Scopoletin in Normal and ANIT-induced Intrahepatic Cholestatic Rats
Authors: Tian Qiru , Jin Huan , Huo Xiaokui , Zhao Yupu , Wu Wenhui , Xu Lei , Wang Yinan , Yang Xiaobo , Sun Chengpeng , Deng Sa , Shu Xiaohong
Published: May 2023

Background:

Scoparone, the principal natural active ingredient of Artemisia capillaries (Yin Chen), can effectively treat cholestatic diseases, but the pharmacokinetic properties of scoparone are rarely studied in intrahepatic cholestatic rats.

Objective:

A sensitive and rapid LC-MS/MS method was established to detect scoparone and its metabolite of scopoletin in rat plasma and then compare their plasma pharmacokinetic differences between the normal and ANITinduced cholestasis rats.

Methods:

Positive ionization was used to separate scoparone and scopoletin using acetonitrile and 0.1 % formic acid water as the mobile phase on a Hypersil ODS-BP column.

Results:

The calibration curves presented good linearity (R=0.9983 and 0.9989) in the concentration range of 10- 10000 ng/mL and 0.5-500 ng/mL for scoparone and scopoletin, respectively. The precision of ≤ 9.4% and the accuracy ranged from -6.4% to 6.8% were recorded over three validation runs, and the recovery was higher than 83.9%. Under different storage conditions, scoparone and scopoletin were stable. Therefore, we studied the pharmacokinetic properties of scoparone and scopoletin in rats after a single oral administration with the above method. According to the results, the pharmacokinetic parameters of AUC, t1/2, and Cmax values of scoparone in the ANIT group were increased by 106%, 75%, and 44%, respectively, while these values of scopoletin were increased by 142%, 62%, and 65%.

Conclusion:

The findings indicated that the pharmacokinetic properties of scoparone and scopoletin were significantly different between the normal and ANIT-induced cholestasis rats, which suggested that the clinical application dosage of scoparone should be adjusted according to the liver function of patients.
Anticancer Drug Discovery By Structure-Based Repositioning Approach
Authors: Modh Dharti H. , Kulkarni Vithal M.
Published: May 2023

Despite the tremendous progress that has occurred in recent years in cell biology and oncology,
in chemical, physical and computer sciences, the disease cancer has continued as the major
cause of death globally. Research organizations, academic institutions and pharmaceutical companies
invest huge amounts of money in the discovery and development of new anticancer drugs. Though
much effort is continuing and whatever available approaches are being attempted, the success of
bringing one effective drug into the market has been uncertain. To overcome problems associated with
drug discovery, several approaches are being attempted. One such approach has been the use of
known, approved and marketed drugs to screen these for new indications, which have gained considerable
interest. This approach is known in different terms as “drug repositioning or drug repurposing.”
Drug repositioning refers to the structure modification of the active molecule by synthesis, in vitro/
in vivo screening and in silico computational applications where macromolecular structure-based drug
design (SBDD) is employed. In this perspective, we aimed to focus on the application of repositioning
or repurposing of essential drug moieties present in drugs that are already used for the treatment of
some diseases such as diabetes, human immunodeficiency virus (HIV) infection and inflammation as
anticancer agents. This review thus covers the available literature where molecular modeling of
drugs/enzyme inhibitors through SBDD is reported for antidiabetics, anti-HIV and inflammatory diseases,
which are structurally modified and screened for anticancer activity using respective cell lines.
Erucic Acid: A Possible Therapeutic Agent for Neurodegenerative
Diseases
Authors: Goyal Ahsas , Dubey Nandini , Verma Aanchal , Agrawal Anant
Published: May 2023

Neurodegenerative disorders are among the most common life-threatening
disorders among the elderly worldwide and are marked by neuronal death in the brain
and spinal cord. Several studies have demonstrated the beneficial role of dietary fatty
acids in different brain disorders. This is due to their neurotrophic, antioxidant, and
anti-inflammatory properties. Furthermore, extensive evidence shows that an unbalanced
intake of certain dietary fatty acids increases the risk of neuropsychiatric diseases.
Several research has been done on erucic acid, an ingestible omega-9 fatty acid that
is found in Lorenzo's oil. Erucic acid was previously thought to be a natural toxin because
of its negative effects on heart muscle function and hepatic steatosis, but it has
been discovered that erucic acid is regularly consumed in Asian countries through the
consumption of cruciferous vegetables like mustard and rapeseed oil with no evidence
of cardiac harm. Erucic acid can also be transformed into nervonic acid, a crucial element
of myelin. Therefore, erucic acid may have remyelinating effects, which may be
crucial for treating different demyelinating conditions. Also, erucic acid exerts antioxidant
and anti-inflammatory effects, suggesting its possible therapeutic role in different
neurodegenerative disorders. Considering the fruitful effects of this compound,
this article reviews the probable role of erucic acid as a pharmacological agent for
treating and managing different neurodegenerative disorders.
[EMIm][BH3CN] Ionic Liquid as an Efficient Catalyst for the Microwave-
Assisted One-Pot Synthesis of Triaryl Imidazole Derivatives
Authors: Manjul Rajesh K. , Gaikwad Suresh T. , Gade Vilas B. , Rajbhoj Anjali S. , Jopale Manohar K. , Patil Shripad M. , Gaikwad Dhananjay N. , Suryavanshi Dayanand M. , Goskulwad Santosh P. , Shinde Suvarna D.
Published: May 2023

In this present investigation, efficient and general protocols for the synthesis of a series of
imidazoles 4(a-p) derivatives have been developed by cyclocondensation of aromatic aldehydes, benzil
and ammonium acetate in the existence of efficient [EMIm][BH3CN] ionic liquid catalyst under
microwave condition in good to excellent yields (91-97%). The structures of the synthesized compounds
have been confirmed by IR and NMR spectra. The significant features of this protocol are an
uncomplicated workup process, rate enhancement with high yields, and efficient catalysts. It was concluded
that [EMIm][BH3CN] is the finest catalyst under MW heating conditions.
Varietal Identification of Cereal Grains: Review
Authors: Deore Anagha , Athmaselvi K.A.
Published: May 2023

Large numbers of grain varieties are exploited for different purposes and their characteristics
contribute in varied manners to the type, quality of the product. The variety of the grain is
an important factor in deciding the value of the product. Identifying these varieties and cultivars is
a crucial procedure in a food supply system. Various methods are employed to identify the variety
of grains based on morphological, biochemical, or genotypic characteristics of the grain. This note
discusses the need for identifying the variety of grains and looks upon various methods that have
been brought into action to meet the purpose. Each method of identification has its own set of
benefits and drawbacks, making it possible to choose the appropriate one for cereal grains at different
stages of the supply chain. The methods of identification described in the review present an
alternative to conventional manual methods. Rapid detection and accuracy are expected from the
identification methods. Lab-on-a-chip, web portals, and QR codes are just a few of the recent solutions
that have the ability to overcome the drawbacks and make variety identification an uncomplicated
job.