bluuebunny/crossref_metadata_2025 huggingface dataset:
A lovaglás core izmokra gyakorolt hatásának vizsgálata
Authors: Biróné Ilics Katalin , Domsi Erzsébet , Nagyváradi Katalin
Published: July 2023

A testmozgás hiánya az emberiség legnagyobb csoportját érintő probléma. Ha izmaink nincsenek megfelelően megdolgoztatva, akkor teljesítőképességük hanyatlik, pedig jelentős feladatuk lenne, többek között a helyes testtartás (Laczkó - Melczer, 2015). A testtartás kialakításában a core izmok döntő szerepet játszanak, mivel jelentős részük eredés vagy tapadás által kapcsolatban van a gerinccel és a medencével (Bajsz – Császárné - Sió, 2012). Kutatásunk célja, a testtartásért felelős izmok erőállóképességének felmérése lovasok körében. Munkánk során arra keressük a választ, hogy: a lovaglás, mint sport feltételezi-e a core izmok fokozott működését? Adatainkat futók és más kutatásokban szereplő sportolók eredményeivel vetettük össze. Vizsgálatunkba 14 lovast (átlag életkoruk: 28 ± 10,4) és 13 futót (átlag életkoruk: 32 ± 13,3) vontunk be. Kritérium volt a sportolóknál, hogy legalább 1 éve, rendszeresen végezzék az adott sportágat. Saját készítésű kérdőív segítségével hátér-információkat gyűjtöttünk pl. az edzések gyakoriságáról, kiegészítő sportágakról. Inbody 720-as eszközt használtunk a sportolók testösszetétel vizsgálatához (Ihász, 2013), illetve a core izmok erőállóképességét többlépcsős alkartámasz tesztel mértük fel. Az adatok elemzéséhez alapstatisztikát, illetve korreláció számítást végeztünk. A lovasok mindegyike elérte a core izmok megfelelő minőségét visszaigazoló gyakorlat 3. percét. Eredményeik a vizsgálatunkban résztvevő futók, illetve további vizsgálatokban szereplő sportolók teljesítményét is meghaladták. A korreláció elemzés során, csak egyes test összetevők között találtunk kapcsolatot (pl. testtömeg-testtömeg index, testmagasság-vázizom tömeg). A lovasok a teszt kritériumoknak megfelelően, fokozott erőállóképességgel rendelkeznek, ezért kijelenthetjük, hogy a lovaglás hozzájárulhat a helyes testtartás megőrzéséhez.
Az idősebb korosztály aktivitásának növelése : Mozgás, légzés, meditáció
Authors: Kulcsár Kata , Jámbor Katalin , Breznai Annamária
Published: July 2023

Visszatekintve az elmúlt néhány évben zajlott világjárvány időszakára szinte mindannyian megtapasztaltuk a magány és az izoláció élményét. A pandémia alatt időszakban jellemző volt a bezártság, a mindennapi ritmus megváltozása. Kevesebbet tudtunk mozogni és ritkábbá váltak a lehetőségek a különböző aktvitások, rekreációs tevékenységek végzésére. A bezártság, a korlátozott mozgáslehetőségek következtében a mozgásszervi funkciók csökkentek. A társas kapcsolatok hiánya pedig sokaknál az érzelmi funkciók beszűkülését eredményezhették. Az izoláció hazánkban is fokozottan érint az idős embereket. Jelen tanulmányban szeretnénk megszólítani mindenkit, mind a segítő szakmában dolgozó szakembereket, mind a társadalom tagjait, hogy támogassuk együttesen az idősebb korosztály társas aktvitásának növelését a magány és az izoláció elkerülése érdekében. Számos programlehetőség kínálkozik az idősebb korosztály számára is, ahol együtt mozgásra, tanulásra, beszélgetésre, kreativitásra ösztönző társakkal kapcsolódhatnak. A szerzők elsősorban a gyógytornász szakmai szempontokat képviselik jelen tanulmányban. A cikk kiemelten foglalkozik a mozgás, a meditáció, a légzés, illetve a tudatos jelenlét témáival annak érdekében, hogy felhívja a figyelmet az öntörődés, önismeret, önszeretet, a befelé figyelés jelentőségére a jóllét és az egészség szempontjából.
Pancasila as Extraction of Sacred Conscript and Social’s Exegesis in Indonesia’s Diversity
Authors: Siregar Muhammad Habibi
Published: July 2023

This article discusses another dimension in the discussion about Pancasila, which aims to create a conducive climate in establishing a social order in society. Many Muslim scholars see Pancasila as the best interpretation, which aligns with the values of the holy book in Islam. Pancasila has a significant role in maintaining the integrity of the Indonesian state and opposing disintegration. In a fragile situation, the pressure to maintain unity is increasing, and Pancasila is the only option to connect all faiths in a society as diverse as Indonesia. This article shows that, as Indonesia's basic interpretation according to Islamic normative texts, Pancasila is the most reliable concept in formulating equality of belief and justice before the law for all people. The research findings show Pancasila's significant contribution to maintaining Indonesia's integrity by ensuring that all elements can contribute to achieving the best results, not only in the field of religion but also in building national pride. Thus Pancasila plays an essential role in maintaining the unity and integrity of the Indonesian state. Pancasila creates a conducive social climate and conforms to Islamic values.
Emerging advances of composite membranes for seawater pre-treatment: a review
Authors: Jaspal Dipika , Malviya Arti , El Allaoui Brahim , Zari Nadia , Bouhfid Rachid , Kacem Qaiss Abou El , Bhagwat Sanjay
Published: July 2023

As the population continues to grow, the preservation of the world's water resources is becoming a serious challenge. The seawater desalination process is considered a sustainable option for the future. The two most common technologies used in desalination are reverse osmosis (RO) and membrane distillation (MD). However, membrane fouling caused by the accumulation of contaminants on the membrane surface is an emerging and growing problem. A pre-treatment stage is required to reach optimal efficiency during the desalination process since this stage is crucial for a successful desalination process. In this regard, the development of new material-based composite membranes has the potential to upgrade the anti-fouling features of RO membranes thereby enhancing desalination efficiency due to their high permeability, hydrophilicity, selectivity mechanical strength, thermal stability, and anti-bacterial properties. The objective of this review is to present various techniques for seawater pre-treatment. The results of the use of several membrane types and methods of modification have also been discussed. The performance of composite membranes for seawater pre-treatment is defined and the future perspectives have been highlighted.
What is the best design approach for estimating effluent concentrations from horizontal flow treatment wetlands: the use of volumetric (kV) or areal (kA) removal rate coefficients?
Authors: von Sperling Marcos , Wallace Scott D. , Nivala Jaime
Published: July 2023

Effluent concentrations from horizontal flow (HF) treatment wetlands can be estimated by using the Tanks-In-Series model for describing hydraulics and first-order removal rate coefficients for describing pollutant removal. In the design of conventional wastewater treatment plants, volumetric removal rate coefficients (kV) are traditionally used in conjunction with the theoretical hydraulic retention time. Areal removal rate coefficients (kA) coupled with the applied areal hydraulic loading rate are widely used in the literature. Despite this, supporting evidence of its appropriateness is scarce in the literature. The objective of this study is to investigate the adequacy of both approaches by analyzing the influence of liquid depth on kV and kA. Data from 74 HF wetlands were collected, covering biochemical oxygen demand and chemical oxygen demand, and diverse types of influents (raw sewage and primary, secondary and tertiary effluents). For these conditions, kV decreased with depth of the wetland system. Regression analyses between depth and removal rate coefficients were performed, and the equations indicated that kV was approximately related to the inverse of depth, while kA was almost independent of depth. These findings endorse the utilization of the areal-based approach for design purposes. The volumetric-based approach can also be used, but the value of kV must be provided together with the depth being considered.
Monitoring and control of smart urban drainage systems using NB-IoT cellular sensor networks
Authors: Roosipuu Priit , Annus Ivar , Kuusik Alar , Kändler Nils , Alam Muhammad Mahtab
Published: July 2023

Narrow-Band-Internet of Things (NB-IoT) is a promising wireless communication technology for harsh signal propagation conditions, including underground connectivity. The purpose of this study is to evaluate the real-life signal quality of an NB-IoT cellular sensor network for the monitoring and control of urban drainage systems. The implementation of the control systems toward smart infrastructures increase the need for low-cost and low-energy-consumption underground sensing devices. A measurement campaign was conducted in Rakvere, Estonia, to analyze the NB-IoT network's coverage and underground signal quality. The results were used to analyze the flood risk reduction potential in the pilot catchment, considering the quality of NB-IoT cellular network coverage. The signal measurements showed that in the case of plastic manholes, the best cellular transmitter placement is 0.5 m below the manhole cover, and at the ground level NB-RSRP reference signal strength of −104 dBm or better must be ensured to have a link budget with optimal energy consumption for communication. The results of flood risk reduction showed that excluding control locations with insufficient signal strength increased the number of major flooding nodes by 3.9% and mean flooding duration by 4.2% which is a relatively small change and characterizes the flexibility of the developed control system.
An integrated approach using multi-source data for effective pollution risk monitoring of urban rivers: a case study of Hangzhou
Authors: Wu Hao , Chen Qianhu
Published: July 2023

With the rapid urbanization of cities, water pollution has emerged as a major challenge to their sustainable development. To tackle this problem, we developed a river pollution risk management system that integrates multi-source data and includes risk identification, early warning, and control. We applied this system to a case study of urban rivers in Hangzhou, China. The results indicated that the measured and effect values of urban river water quality in Hangzhou were 1.01 and 1.14, respectively, indicating mild pollution levels. NH3-N is the main risk factor, with poor supervision and land use being the main risk sources. River pollution risk in different drainage zones demonstrated stratification. Since 2012, the measured risk of water quality in Hangzhou has been decreasing, mainly concentrated in the built-up area; however, the effect risk has been increasing, especially in the new center and sub-center of the city. Based on these findings, three strategies for urban river pollution control are suggested: water ecology source rehabilitation, water environment process supervision, and water pollution end management. The results of this study extend the understanding of urban water environment risk and provide implications for sustainable urban planning.
Small Molecule Inhibitors of Human Papillomavirus: A Review of
Research from 1997 to 2021
Authors: Duncan Caitlin L. , Gunosewoyo Hendra , Mocerino Mauro , Payne Alan D.
Published: July 2023

:

Human papillomavirus (HPV) infections are the cause of warts, lesions and
cancer, with different types of HPV causing different symptoms. HPV infections are the
primary cause of cervical cancer. There are over 220 different types of HPV, and only
nine of these can currently be vaccinated. There is a need to treat these viral infections
without just treating the symptoms of the infection, as is currently the main method. There
is a wide range of small molecules that have been used to inhibit various stages of the
HPV infectious cycle. This review examined 132 small molecules from 121 studies that
specifically target aspects of HPV infections. HPV DNA encodes for six early genes (E1
to E7, skipping E3) and two late genes (L1 and L2). According to the results, these targets
for small molecule inhibitors fall into three categories: those targeting E1 and E2, targeting
E6 and E7 and, finally, targeting L1 and L2. Inhibitors of E6 and E7 are the most
widely studied targets, with the majority of HPV inhibition in this area. While compounds
targeting both E1/E2 and E6/E7 have made it to clinical trials, there has been no significant
advancement on the topic.
A Review on the Mechanism and Structure-activity Relationship of
Resveratrol Heteroaryl Analogues
Authors: Xiang Yijun , Xu Yao , Li Jiaxin , Jiang Jingyi , Wang Yanjie , Li Xiaoshun , Ai Wenbin , Mi Pengbing , Yang Zehua , Zheng Zitong
Published: July 2023

Resveratrol is one of the most interesting naturally-occurring nonflavonoid phenolic
compounds with various biological activities, such as anticancer, neuroprotection, antibacterial,
and anti-inflammatory. However, there is no clinical usage of resveratrol due to either its poor activity
or poor pharmacokinetic properties. Heteroarenes-modified resveratrol is one pathway to improve
its biological activities and bioavailability, and form more modification sites. In this review,
we present the progress of heteroaryl analogues of resveratrol with promising biological activities
in the latest five years, ranging from the synthesis to the structure-activity relationship and mechanism
of actions. Finally, introducing heteroarenes into resveratrol is an effective strategy, which
focuses on the selectivity of structure-activity relationship in vivo.
Recent Progress in Environmentally-Friendly Methods for Chalcone
Synthesis
Authors: Makwana Jeky C. , Dabhi Ranjitsinh C. , Shrivastav Pranav S. , Maru Jayesh J.
Published: July 2023

Chalcones are important scaffolds in the field of medicinal chemistry due to the presence of
α,β-unsaturated ketone functionality. They are usually synthesized by reacting an aldehyde with acetophenone
in the presence of acid or base using the Claisen-Schmidt condensation reaction. Numerous
chalcone derivatives have been developed due to the simplicity of their synthesis, and they have
intriguing biological activity that has clinical implications for a range of disorders. The review article
discusses the advancements made since 2005 for the synthesis of chalcones derivatives using environmentally
friendly methods such as the use of green catalysts and solvents, ultrasonic radiation, microwave
energy, and methodologies involving grinding in the absence of solvents.
WITHDRAWN: Utilization of Computational Tools for Discovery of Reticuline Based Derivatives as AChES Inhibitors to Treat Alzheimer’s
Disease
Authors: Handa Jasmeen , Kumari Baby , Negi Samir , Arora Pinky , Kumar Shubham
Published: July 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn from the journal Letters in Drug Design & Discovery.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php.

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authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright
of their article is transferred to the publishers if and when the article is accepted for publication.
Comparative Analysis of Ultrasound Diagnosis and Pathological Characteristics
of External Jugular Venous Aneurysm
Authors: Cui Liyuan , Wang Tiezheng , Liu Lihua , Teng Jianbo , Qi Hengtao
Published: July 2023

Purpose:

This study aimed to investigate the diagnosis of the external jugular venous aneurysm on color Doppler ultrasound and its relationship with pathological characteristics.

Methods:

A retrospective analysis of 17 patients with external jugular venous aneurysm admitted to the Provincial Hospital Affiliated with Shandong First Medical University from May, 2010, to June, 2020, was performed. The color Doppler ultrasound characteristics of 17 patients with external jugular vein aneurysms were analyzed and summarized, which were then compared with postoperative pathological outcomes.

Results:

All 17 patients with external jugular venous aneurysms were presented with cystic structures adjacent to and communicated with the external jugular vein. Color Doppler flow imaging showed a bidirectional venous flow signal in the communication between the cystic structure and the external jugular vein. Among the 17 patients, ultrasound diagnosis showed true venous aneurysm due to degenerative changes in the venous wall in 8 cases, venous pseudoaneurysm in 4 cases, and external jugular venous aneurysm in 5 cases, and postoperative pathology indicated degenerative changes in the venous wall in all 17 patients.

Conclusion:

Bidirectional blood flow at the communication between the cystic lesion and the external jugular vein on color Doppler ultrasound should not be the criterion for the diagnosis of external jugular venous pseudoaneurysm, which requires pathological support.
Can Uterine Artery Pulsatility Index Predict Fetal Chromosomal Abnormality
in Early Pregnancy Loss? A Retrospective Cohort Study
Authors: Cao Yunyun , Chen Yiyao , Wang Guanjie , li Shuyuan , Liu Zhiwei
Published: July 2023

Background:

Early pregnancy loss (EPL) or spontaneous loss of an intrauterine pregnancy within the first trimester occurs commonly worldwide. It is useful to predict the possibility of fetal chromosomal abnormalities using other cheap and easily available markers.

Objective:

This study aimed to evaluate whether the uterine artery pulsatility index (UtA-PI) can predict fetal chromosomal abnormality in early pregnancy loss (EPL).

Methods:

This was a retrospective cohort study including 148 women who underwent dilation and curettage for missed abortion. The UtA-PI was measured and evaluated by transvaginal ultrasound. Abnormal UtA-PI was identified through the mean of left and right UA-PI ≥ 90th percentiles of the relevant values for the corresponding gestational age. Copy number variation sequencing (CNV-seq) was performed on EPL cases without maternal cell contamination.

Results:

107 (72.3%) cases were classified with normal UtA-PI, while 41 (27.7%) cases were classified with abnormal UtA-PI. The fetal chromosomal abnormality rate was significantly higher in cases with normal UtA-PI than in those with abnormal UtA-PI (67.3% vs 22.0%, P = 7.1 x 10-7). Compared to cases with abnormal UtA-PI, the risk of fetal chromosomal abnormalities in cases with normal UtA-PI increased with an odds ratio of 7.3 (95% confidence interval [CI]: 3.2‒17.0, P = 4 x 10-7). The predictive value of normal UtA-PI alone for fetal chromosomal abnormalities was shown to have an area under the curve of 0.67‒0.71 in our population.

Conclusion:

The UtA-PI seems to be lower and less likely to be elevated in EPL with fetal chromosomal abnormalities compared to those without aneuploidies. We suggest that UtA-PI should be examined in all EPL patients.
Marcelo Montenegro, o analogista ou Na mnemotécnica do afeto
Authors: Manzoni Filipe
Published: July 2023

This article aims to investigate the poetry of Marcelo Montenegro through the central paradigm of the analogy. First, it will sketch a heuristic concept of analogy based on the structuralism, than extend it to three recurrent structures/themes in Montenegro’s poems, connecting them through the central kernel of the analogic and the analogy. Furthermore, this paper will unravel a link between analogy/analogic and memory in two scenarios: one centered on the technological means of inscription/registration of data, and other on a psychological/linguistic notion of memory.
XXVII Международный симпозиум Нанофизика и наноэлектроника", Нижний Новгород, 13-16 марта 2023 г. Формирование заряженных вакансий в анионной подрешетке AlAs
Authors: Шамирзаев Т.С.
Published: July 2023

The vacancy formation dynamics in doped semicon-
ductor heterostructures with quantum dots (QDs) formed in the
AlAs anionic sublattice has been studied. A theoretical model that
describes the effect of doping on the vacancy generation dynamics
is constructed. It is shown that the generation of positively
charged arsenic vacancies is more probable than the generation
of neutral ones at high hole concentrations. On the other hand,
at high electron concentrations, the formation of neutral arsenic
vacancies is more efficient than that positively charged ones. It has
been experimentally revealed that the vacancy-stimulated high-
temperature diffusion of antimony is enhanced (suppressed) in
p-(n-)-doped heterostructures with Al(Sb,As)/AlAs QDs.
ГКР-активные подложки на основе внедренных наночастиц Ag в объем c-Si: моделирование, технология, применение
Authors: Ермина А.А. , Солодовченко Н.С. , Пригода К.В. , Левицкий В.С. , Павлов С.И. , Жарова Ю.А.
Published: July 2023

A simple method for obtaining SiO2 : Ag : Si and Ag : Si hybrid nanostructures is presented. High-temperature treatment of an island film of Ag on the surface of c-Si makes it possible to preserve the plasmonic properties of Ag nanoparticles and protect them from external influences by coating them with a thermally grown layer of SiO2. The calculation of the electric field strength distribution in the structure with embedded Ag nanoparticles in c-Si demonstrates the presence of intrinsic “hot spots” at the corners of the nanoparticles, which leads to a maximum enhancement factor (~10^6) of Raman scattering. scattering. A numerical calculation of the dependence of the spectral position of a localized plasmon resonance on the geometry of structures can serve as a basis for their design in the future. Surface-enhanced Raman scattering spectroscopy showed reliable detection of the methyl orange from an aqueous solution at a concentration of 10^-5 M.
Переход между законами Мотта и Аррениуса в температурных зависимостях сопротивлений сильно легированных бором дельта-слоев в искусственном алмазе
Authors: Кукушкин В.А. , Лобаев М.А. , Вихарев А.Л. , Горбачев А.М. , Радищев Д.Б. , Архипова Е.А. , Дроздов М.Н. , Кукушкин Ю.В. , Исаев В.А. , Богданов С.А.
Published: July 2023

Experimental temperature dependence of the resistiv-
ity of thin (1−3 nm) highly boron-doped (close to the threshold of
the phase transition into a state with a metallic-type conductivity)
delta-layers in chemically vapor deposited (CVD) diamond in a
broad temperature range from ∼ 100 to ∼ 500 K can be described
by Mott’s two-dimensional law (hole ”hops“ between localized
states with a temperature-dependent average ”hop“ length) in a
low temperature region and Arrhenius’ law (hole ”hops“ between
the nearest localized states) in a high temperature region. The
crossover between them takes place at 230−300 K. The potentials
of hole localized states are of a long-range, e. g. Coulomb’s, type,
the static dielectric permittivities of delta-layers are by several times
larger than those of undoped CVD diamond.
Проявление диполь-дипольного и квадрупольного взаимодействий в спектре коррелятора оптически охлажденных ядерных спинов объемного кристалла n-GaAs
Authors: Литвяк В.М. , Чербунин Р.В. , Солдатенков Ф.Ю. , Калевич В.К. , Кавокин К.В.
Published: July 2023

In this work, we measured the correlator spectrum of optically cooled nuclear spin system of a bulk n-GaAs crystal in a zero magnetic field. The resulting spectrum is described by two contours, which can be interpreted as the participation of nuclear spins in two types of interactions. We analyzed the measured spectrum in the model for classical magnetic moments in the GaAs lattice. The analysis showed that the main contribution to the high-frequency part of the spectrum is due to the dipole-dipole interaction, and that to the low-frequency part is due to the quadrupole interaction.
Температурная зависимость дислокационной электролюминесценции в кремниевых светодиодах с кислородными преципитатами
Authors: Соболев Н.А. , Калядин А.Е. , Штельмах К.Ф. , Аруев П.Н. , Забродский В.В. , Шек Е.И.
Published: July 2023

Electroluminescence has been studied in silicon light-emitting diodes containing oxygen precipitates at temperatures of 40-300 K. Oxygen ion implantation and multistage anneals are used for fabrication of the diodes. Over all temperature range, spectra are well approximated by one Lorentz and four Gaussian curves. Lines of dislocation-related luminescence D1-D4 (the D1 line is described by Lorentz curve) and oxygen precipitates (OPs) are present in the spectra. At temperature variation, peak positions of the D1, OP and D2 lines coincide with temperature dependence of the forbidden gap width reduced by values of 356, 330 and 303 meV respectively. Build and quenching areas are observed on temperature dependences of the electroluminescence intensities of the D1, OP and D2 lines, the activation energies of the processes are determined, and reasons of their appearance are discussed.
Political inheritance in Islamic political thought
Authors: Yas Gaffurry Rashid Emara , Hamad Mubarak Aziz
Published: July 2023

The concept of political inheritance is one of the modern concepts that address an old and very sensitive issue, which is the issue of power and how to assume it, which has provoked a lot of reaction among thinkers and philosophers since ancient times, and one of the most controversial issue in Islamic thought since the death of Prophet, may God bless him and grant him peace, and Muslims were divided around it and then on other sub-issues on two main sects, namely: Shiite sect and Sunni sect.      
Each of them has its arguments and chains of support in the issue of political inheritance, as the Shiite thought approved political inheritance, on the basis that it is stipulated in the two sources of Islamic legislation, and made it the monopoly of the infallible imams of the descendants of Ali Ibn Abi Talib and then in his son Hussein and ended up with them to new theories moving away from the political inheritance stipulated as they believe to the public and private guardianship of the jurist, which relied in essence on the choice of the guardian jurist conditional on waiting for the appearance of the adsent imam.
 As for Sunni jurisprudence, which denied the existence of the text of political inheritance in the Quran and the Sunnah of the prophet and cornered on the issue of Shura and the choice of the solution and the contract, but supported all forms of political inheritance since the era of Muswiya bin Abi Sufyan, founder of the Umayyad state through the Abbasid state, on the basis of the condition of the Quraysh, which he quikly abandoned in favor of political inheritance from outside the Quraysh in particular and the Arabs in general, by inventing the condition of mastery and dominance by supporting the Ayyubid state, the Qttoman Empire and others.
After these experiences, Islamic political thought meests its Snni and Shiite wings in today’s world at the present time by choosing only the wail al-faqih or the ruling caliph, so that Islamic thought carries a wide heritage and with different arguments for forms of political inheritance that support everyone who adheres to the inheritance of power.
Intrinsic Capacity and Active and Healthy Aging Domains Supported by Personalized Digital Coaching: Survey Study Among Geriatricians in Europe and Japan on eHealth Opportunities for Older Adults
Authors: Stara Vera , Soraci Luca , Takano Eiko , Kondo Izumi , Möller Johanna , Maranesi Elvira , Luzi Riccardo , Riccardi Giovanni Renato , Browne Ryan , Dacunha Sébastien , Palmier Cecilia , Wieching Rainer , Ogawa Toshimi , Bevilacqua Roberta
Published: July 2023

Background

The worldwide aging trend requires conceptually new prevention, care, and innovative living solutions to support human-based care using smart technology, and this concerns the whole world. Enabling access to active and healthy aging through personalized digital coaching services like physical activity coaching, cognitive training, emotional well-being, and social connection for older adults in real life could offer valuable advantages to both individuals and societies. A starting point might be the analysis of the perspectives of different professionals (eg, geriatricians) on such technologies. The perspectives of experts in the sector may allow the individualization of areas of improvement of clinical interventions, supporting the positive perspective pointed out by the intrinsic capacity framework.

Objective

The overall aim of this study was to explore the cross-national perspectives and experiences of different professionals in the field of intrinsic capacity, and how it can be supported by eHealth interventions. To our knowledge, this is the first study to explore geriatric care providers’ perspectives about technology-based interventions to support intrinsic capacity.

Methods

A survey involving 20 geriatricians or clinical experts in the fields of intrinsic capacity and active and healthy aging was conducted in Italy, France, Germany, and Japan between August and September 2021.

Results

The qualitative findings pointed out relevant domains for eHealth interventions and provided examples for successful practices that support subjective well-being under the intrinsic capacity framework (the benefits offered by personalized interventions, especially by promoting health literacy but avoiding intrusiveness). Moreover, eHealth interventions could be used as a bridge that facilitates and enables social engagement; an instrument that facilitates communication between doctors and patients; and a tool to enrich the monitoring actions of medical staff.

Conclusions

There is an unexplored and significant role for such geriatric perspectives to help the development process and evaluate the evidence-based results on the effectiveness of technologies for older people. This is possible only when clinicians collaborate with data scientists, engineers, and developers in order to match the complex daily needs of older adults.
Examining Predictors of Depression and Anxiety Symptom Change in Cognitive Behavioral Immersion: Observational Study
Authors: Ezawa Iony D , Hollon Steven D , Robinson Noah
Published: July 2023

Background

Depressive and anxiety disorders are the most common mental disorders, and there is a critical need for effective, affordable, and accessible interventions. Cognitive Behavioral Immersion (CBI) is a novel group-based cognitive behavioral skills training program delivered by lay coaches in the metaverse that can be accessed through various modalities including virtual reality (VR) head-mounted displays or flat-screen devices. Combining its ability to offer empirically supported therapy skills in a digital setting that can still facilitate interpersonal variables (eg, working alliance and sense of social support) with the aid of lay coaches, CBI has the potential to help fill this critical need.

Objective

This study had 2 primary aims. First, we aimed to examine changes in depression and anxiety symptoms in a sample of individuals who participated in CBI. Second, we aimed to examine 2 interpersonal process variables (working alliance and web-based social support) as predictors of symptom changes. We predicted CBI participants would experience depression and anxiety symptom improvements and that such improvements would be associated with an increase in both interpersonal process variables.

Methods

The study sample consists of 127 participants who endorsed clinical levels of depression or anxiety symptoms during their first CBI session and attended at least 2 sessions. Participants were asked to complete self-report measures of depression symptoms, anxiety symptoms, alliance, and web-based social support throughout their participation in CBI.

Results

Repeated measures ANOVAs determined that depression and anxiety symptom scores differed significantly across sessions (Ps<.01). We also found participants’ web-based social support predicted improvement in depression symptoms (P=.01), but neither the alliance nor web-based social support predicted change in anxiety symptoms (Ps>.05). We also observed a significant difference in anxiety symptoms between participants who used a VR head-mounted display to access CBI and those who did not, such that participants who used VR head-mounted displays endorsed lower anxiety symptoms than those who did not at nearly every session (P=.04).

Conclusions

Participation in CBI is associated with both depression and anxiety symptom improvement. Web-based social support may play an important role in fostering changes in depression symptoms. Future studies are encouraged to continue examining the process of change in CBI with special attention paid to methods that can elucidate causal mechanisms of change.
Mohs Surgery Price Transparency and Variability at Academic Hospitals After the Implementation of the Federal Price Transparency Final Rule (Preprint)
Authors: Jain Neelesh P , Gronbeck Christian , Beltrami Eric , Feng Hao
Published: July 2023

UNSTRUCTURED

This paper reports on price variability and transparency in Mohs micrographic surgery as reported by academic hospital systems since the implementation of the Hospital Price Transparency Final Rule by the US federal government.
Multidisciplinary view of INtimacy, PRIvacy and COnfidentiality (INPRICO) in local primary health care practices using the INPRICO rural survey during COVID-19: protocol for a cross-sectional descriptive study. (Preprint)
Authors: Panadés Zafra Robert , Torrents Comas Maria Teresa , Caballero Humet Isabel , Aymerich Mestre Anna , Panadés Zafra Mercè , Grau Vila Josep Lluis , Merino Martínez Cristina , Homs Riba Maria
Published: July 2023

BACKGROUND

Confidentiality is a fundamental right in health care, reaffirmed by the World Medical Association Declaration of Geneva. Every person has the fundamental right to privacy, intimacy and confidentiality.

OBJECTIVE

To assess the perception of confidentiality, intimacy and privacy in primary health care (PHC), in local clinics and in a multidisciplinary context.

METHODS

Cross-sectional descriptive study of PHC professionals and users in rural areas. An anonymous Likert scale survey (called INPRICO) will be applied and the answers will be digitised with Teleform©. Professionals and users’ perceptions will be compared by means of the INPRICO questionnaire.

RESULTS

This study investigates intimacy, privacy, and confidentiality in primary health care. A higher participation of women and the 45-64 age group is expected. With a higher age, a lower perception of privacy is expected. Differences will be found in genital intimacy and pandemic impact, but not in confidentiality. Users are likely to be more accepting of professionals' access to their data because of the pandemic. There will be no significant differences according to place of birth. In general, we believe that they will be of the opinion that it not necessary for the administrative team to have access to health data. This study provides relevant information on attitudes and perceptions of these aspects in primary health care.

CONCLUSIONS

Despite the sensitivity of the subject, there is a lack of exploration of this area. The INPRICO questionnaire can be a useful tool for assessing these aspects, but it needs to be validated. These aspects have worsened during the COVID-19 pandemic. More studies are needed to further investigate these aspects.
Artificial Intelligence–enabled Social Media Listening: Approaches and Strategies to Inform Early Patient-focused Drug Development (Preprint)
Authors: Spies Erica , Flynn Jennifer A. , Guitian Oliveria Nuno , Karmalkar Prathamesh , Gurulingappa Harsha
Published: July 2023

UNSTRUCTURED

Patient-focused drug development (PFDD) aims to incorporate the patient perspective to improve the quality, relevance, safety, and efficiency of drug development and to inform drug evaluation. Gathering patient perspectives to support PFDD has become more feasible with the increased digital presence and participation of patient groups that communicate their treatment experiences, needs, preferences, and priorities through online forums. Social media listening (SML) is a method of gathering a substantial amount of feedback directly from patients themselves; however, the quantity of data produced can be challenging to distill into actionable insights. Artificial intelligence (AI)–enabled methods have been leveraged to process data from SML studies, such as natural language processing (NLP) approaches to produce qualitative data. Here, we describe a novel, trainable, AI-enabled, SML workflow to classify posts made by patients or caregivers that uses NLP methods to provide qualitative data regarding patient or caregiver experiences. We report an overview of the workflow and methodologic learnings from 2 studies in oncology. Our approach is an iterative process balanced between human expert–led milestones and AI-enabled processes to support data preprocessing (ie, relevancy screening), patient and caregiver classification, and NLP methods (tagging of relevant patient experience concepts) to produce qualitative data. We explored the applicability of this workflow in 2 case studies in oncology, one in patients with head and neck cancers and another in patients with esophageal cancer. We found that iterative refinement of AI-enabled algorithms was essential in enhancing the utility of the results, which was possible due to the seamlessly native end-to-end nature of the workflow. This approach and workflow contribute to the establishment of well-defined standards of SML studies and advance the methodologic quality and rigor from the perspective of researchers contributing to, conducting, and evaluating SML studies in a PFDD context.
Identifying Shared Opioid Supplies from Public Data on Opioid Deaths (Preprint)
Authors: Imhof Peter
Published: July 2023

UNSTRUCTURED

Opioid-related, accidental death counts have increased in North America over the past decade, leading to the notion of an ‘opioid crisis’. In recent years, the majority of deaths involving opioids were due to illicit fentanyl, connecting deaths more strongly with illicit activities. This study presents a straightforward approach to determine if two locations shared the same opioid supply during a specific period of time. It is based on the assumption that synchronized death counts in two locations over a specific period of time highlight locations that shared opioid supplies. Data on accidental opioid deaths is publicly available in many health jurisdictions. The proposed analysis operates on data from pairs of locations of interest and involves calculating the Pearson correlation coefficients and the related p-values to check for statistical significance. Statistically significant coefficients higher than 0.5 identify locations as sharing access to the same opioid supply. As an example, data from the “Alberta substance use surveillance system” for the time from January 2019 until June 2022 is analyzed to identify connected opioid supplies in seven cities in Alberta, Canada. The limitations of this approach are discussed. This study describes how to provide information about shared supplies of illicit opioids to support health and social service providers, municipal administrators, or law enforcement agencies to respond to the public health concerns related to the opioid crisis.
Асоціації варіантів гена GHRL із розвитком ожиріння та метаболічних порушень у дітей
Authors: Abaturov A. , Nikulina A.
Published: July 2023

Актуальність. Однонуклеотидні варіанти (single nucleotide variant — SNV) гена греліну (GHRL) супроводжуються продукцією дефектного протеїну препрогреліну, що може призводити до розвитку ожиріння та метаболічних порушень. Мета: вивчити асоціації гена SNV GHRL із розвитком різних фенотипів ожиріння в дітей. Матеріали та методи. Обстежено 252 пацієнтів з ожирінням віком 6–18 років. Основну групу (n = 152) становили діти з метаболічно нездоровим ожирінням (МНО). Контрольну групу (n = 100) представили діти з метаболічно здоровим ожирінням (MЗO). У 31 дитини основної та 21 дитини контрольної групи проведено повногеномне секвенування (CeGat, Німеччина). Рівень інтерлейкіну (IL) 1β у сироватці крові визначали методом імунохемілюмінесцентного аналізу, IL-6 — методом імуноферментного аналізу (Synevo, Україна). Результати. Асоціація з розвитком MНO була вищою для T-алеля SNV rs696217 гена GHRL у здорових осіб (t = 2,31; p < 0.05) та пацієнтів з ожирінням (t = 2,06; p < 0,05). Генотип GT SNV rs696217 був пов’язаний з інсулінорезистентністю (r = 0,40; p < 0,05) у групі MНO і зворотно корелював з умістом холестерину (r = –0,45) та холестерину ліпопротеїнів низької щільності (r = –0,39). Генотип TA SNV rs4684677 корелював із рівнем IL-6 (r = 0,74) у групі MЗO та з IL-1β (r = 0,35) у групі MНO, p < 0,05. Профілактика трансформації MЗO в MНO визначається T-алелем SNV rs34911341 (t = 2,29, p < 0,05). Висновки. Міссенс-варіанти rs696217, rs4684677 гена GHRL є SNV, високо асоційованими з ожирінням та розвитком метаболічних порушень.
The Financing Principles of High Carbon Enterprises Green Development Based on Double Carbon Target in China—Take MYSE as an Example
Authors: An Dingchao , Zhang Yuning
Published: July 2023

The “double carbon target” puts forward new requirements for China’s energy structure adjustment. As a leader in offshore wind power equipment, MYSE is an active practitioner of the concept of “carbon neutrality”. The company has established a green growth path and is actively experimenting with various green financial instruments to meet its rapidly growing capital needs. This paper describes in detail the “double carbon goal” to promote the intelligent green development of MYSE, as well as the diversified financing strategy based on green development. Taking the company’s experience of issuing green notes, green bonds, listing on London Stock Exchange and obtaining the “Green economy mark” as examples, this paper analyzes the conditions and strategies of green financing for high-carbon enterprises, and deeply understands the mutual support and promotion relationship between green development and green finance of companies. Deeply understand the positive significance of innovative financing channels and the use of green financing tools for the company’s green development, and provide reference and inspiration for local high-carbon enterprises to actively use green financing tools.
A RETROSPECTIVE STUDY OF HISTOMORPHOLOGICAL SPECTRUM OF HANSEN’S DISEASE IN A TERTIARY CARE CENTRE OF BARABANKI AREA
Authors: Radha  , Goyal Megha , Choudhary Mahima , Ikram Arshad
Published: July 2023

Objectives: Hansen’s disease is a chronic granulomatous infectious disease caused by Mycobacterium leprae. Early detection is essential to prevent the disease’s spread and disability. Due to the multitude of morphologies, it may be difficult to accurately diagnose certain cases based solely on clinical signs; therefore, histopathology is crucial for definitive diagnosis. The study aims to investigate the various histological forms of leprosy over a year in a tertiary care hospital.
Methods: It was a retrospective study that included 25 leprosy cases that were clinically and histopathologically diagnosed from July 2021 to August 2022 in a tertiary care center.
Results: The majority of the cases were from the second decade with the male predominance of the cases (M:F=1.5:1). According to histomorphology, tuberculoid leprosy was the most common type (36%), followed by borderline tuberculoid (24%), borderline lepromatous (16%), lepromatous leprosy (8%), borderline leprosy (8%), histoid leprosy (4%), and indeterminate leprosy (4%). Ziehl–Neelsen staining for acid-fast bacilli demonstrated positivity in 8 cases.
Conclusion: As the clinical spectrum of leprosy is diverse, histopathology is the gold standard for the diagnosis and a key tool in obtaining a conclusive diagnosis.
URINALYSIS AS A PREDICTOR FOR URINARY TRACT INFECTION: AN OBSERVATIONAL STUDY
Authors: K Swetha , B Sravanthi , M Sridhar , Urooj Aqsa , K Ratnamala
Published: July 2023

Aims and Objectives: The aims and objectives of the study are to find the usefulness of urine dipstick and urinalysis in children with an intention to identify the parameters which most likely point toward the presence of urinary tract infection (UTI), whether a combination of the parameters analyzed rather than single parameter is useful in suggesting the presence or absence of UTI. Methods: The study was a prospective observational study done in 401 children below 16 years of age with clinically suspected UTI. Results: The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of dipstick leukocyte esterase (LE) and nitrite were 85%, 93.1%, 75.6%, 96.1% and 51.2%, 99.1%, 93.2%, 89.1%, respectively. In urine microscopic analysis, the sensitivity, specificity, PPV, NPV of bacteria were 68.5%, 96.9%, 84.6%, and 92.6% and those of pus cells were 80%, 93.1%, 74.4%, and 94.9%. Conclusion: Combination of parameters, i.e., LE, nitrite, and bacteria or LE, nitrite, and pus cells are good screening tools to predict and rule out UTI. Of the individual parameters analyzed, negative nitrites in dipstick and absence of bacteria in urine microscopy almost rule out UTI caused by most uropathogens.
COMPARISON OF MAGNETIC RESONANCE IMAGING AND MUTIDETECTOR COMPUTER TOMOGRAPHY FOR THE DIAGNOSIS OF MEDIASTINAL TUMORS
Authors: M SURESH KUMAR
Published: July 2023

The aim of this study is to identify the diagnostic accuracy of mediastinal masses using multidetector computed tomography (MDCT) and magnetic resonance imaging (MRI). A total of 30 cases were referred to the Department of Radiodiagnosis for clinically suspected mediastinal masses for 2 years were included and MDCT and MRI were done. Lymphoma in 37.5% of cases, lymphoma and thymic masses in 31.25% of cases, Ca. esophagus and Schwannoma were the common mediastinal masses in the anterior, superior, middle, and posterior mediastinal compartments, respectively. MDCT sensitivity was 100% and MDCT specificity was 75%. MRI sensitivity was 100%, and MRI specificity was 80%. It was concluded that MDCT is a highly useful modality for the investigation of the mediastinal masses. It has the major role to play in the evaluation of a mediastinal mass regarding the organ of origin, its density, mass effect on adjacent structures, distribution pattern, and extent of the lesion diagnosis. MRI accurately well-characterized mediastinal mases such as thymoma, lymphoma, neurogenic tumor, Schwannoma, and ganglioneuroma. MRI was useful in the characterization of the normal thymus and differentiation of hyperplastic thymus and thymictumors.
The Effect of Financial Literacy, Personal Income, and Locus of Control in Long-Term Gold Investment Decision
Authors: Amanda  , Bambang Widagdo  , Fika Fitriasari
Published: July 2023

The purpose of this study is to find out whether there is an influence of financial literacy, personal income, and locus of control on the investment decision of installment gold. This type of research uses quantitative methods with a sample of 97 respondents. Sources of data obtained in this study from distributing questionnaires. While the data analysis technique used in this study uses multiple linear regression analysis. The results of this study indicate that financial literacy has a positive and significant effect on investment decisions in installment gold. Personal income does not affect gold installment investment decisions. Locus of control has a positive and significant effect on gold installment investment decisions. In addition, financial literacy has a dominant influence on investment decisions in gold installments.