bluuebunny/crossref_metadata_2025 huggingface dataset:
Egészséggel kapcsolatos célok Crohn-betegek körében.
Authors: Festő Blanka , Njers Sanela , Dávid Anett , Horvát Barbara , Sallay Viola , Molnár Tamás , Rafael Beatrix , Martos Tamás
Published: July 2023

Bevezetés: A gyulladásos bélbetegségek, köztük a Crohn-betegség,
jelentősen befolyásolják az érintettek életvitelét, egész életre szóló
odafigyelést igényelve az egészség-magatartás vonatkozásában.
Célkitűzés: Kutatásunk célja a Crohn-betegek egészséggel
kapcsolatos céljainak, az azzal kapcsolatos érzelmeknek, az infokommunikációs
eszközök használatának és e jellemzők együttjárásának vizsgálata volt.
Módszer: A vizsgálatban 79 Crohn-beteg vett részt (59,5%
nő, átlagéletkor: 40,7 év, SD = 11,89). A személyek demográfiai, valamint
egészség-magatartással kapcsolatos kérdésekre válaszoltak, és a Személyes
Egészségtervek Kérdőívet töltötték ki, melyben személyes egészségcéljaikat, egy
aktuálisan fontos egészségcéllal kapcsolatos pozitív és negatív érzelmeiket, a
kezelőorvossal való kapcsolatból származó, a személyes egészségcélhoz fűződő
társas támogatás fokát, az egészségcélok megvalósításának negatív és pozitív
hatásait (akadályoztatás/támogatás), valamint a digitálistechnológia- és
internethasználatot vizsgáltuk. Eredmények: A betegek 70%-a
fogalmazott meg legalább egy egészségcélt. Az egészségcélok négy kategóriába
voltak besorolhatók: fizikai aktivitás (43,6%), stresszkezelés (25,4%),
táplálkozás (18%) és dohányzásról való leszokás (7%). Az egészségcéllal
kapcsolatban a résztvevők 71%-a legalább átlagos mértékben él át pozitív
érzelmeket, körülbelül az 50%-uk azonban negatív érzéseket is megél. Az
egészségcéllal rendelkezők 51%-a használja rendszeresen az internetet és az
okostelefonokon működő applikációkat. Az infokommunikációs eszközök használata
az egészség-magatartási tényezők közül a fizikai aktivitással (ρ = 0,40,
p<0,01) és a táplálkozással (ρ = 0,36, p<0,005) mutatott pozitív
együttjárást. Megbeszélés: A betegek több mint kétharmada
fogalmazott meg egészségcélt; a célok többsége a Crohn-betegség szempontjából is
fontos egészség-magatartási tényezőkkel függött össze, ám a dohányzásról való
leszokást kevesen (a 30 dohányzó személyből mindössze 4-en) tűzték ki
egészségcélul. Az egészségcéllal rendelkezők fele használ rendszeresen
infokommunikációs eszközöket. Az egészség-magatartási tényezők közül a fizikai
aktivitás és a táplálkozás mutatott szignifikáns együttjárást az
infokommunikációs eszközök használatával. Következtetés: A
Crohn-betegek gondozása során javasolt a betegek egészségcéljainak és
infokommunikációseszköz-használatának vizsgálata. Ezáltal speciális
intervenciókat lehetne kidolgozni egészség-magatartásuk javítására, ezáltal
javulhat az életminőség és a betegség prognózisa. Orv Hetil. 2023; 164(28):
1102–1110.
Szaruhártya-átültetés a 21. század elején
Authors: Módis László , Lukács Miklós , Makhoul Sára
Published: July 2023

Szaruhártya-átültetés (keratoplasztika) akkor szükséges, amikor különböző
kórállapotok következtében konzervatív kezeléssel nem gyógyítható, súlyos
látáscsökkenéssel járó szaruhártyahomályok alakulnak ki, vagy a cornea szabályos
szerkezete, görbülete torzul, funkciója elvész. A humán transzplantációk között
a keratoplasztika a legsikeresebb műtéti eljárás. Az utóbbi évtizedekben a
perforáló keratoplasztikák helyét egyre inkább átveszik a lamelláris
transzplantációk, amikor csak a cornea kóros rétegét ültetjük át. Az elülső
forma a mély elülső lamelláris keratoplasztika („deep anterior lamellar
keratoplasty” – DALK), mely elsősorban keratoconusban ajánlott. A hátsó
lamelláris transzplantáció fő formája a Descemet leválasztásos automatizált
endothelialis keratoplasztika („Descemet’s stripping automated endothelial
keratoplasty” – DSAEK) és a Descemet-membrán endothelialis keratoplasztika
(„Descemet’s membrane endothelial keratoplasty” – DMEK). Indikációja az
endothelium pusztulásával járó szürkehályog-műtét után kialakuló keratopathia
bullosa és a Fuchs endothelialis dystrophia. A lamelláris keratoplasztikáknak
több előnyük van a perforáló műtétekkel szemben. Jobb a posztoperatív
látóélesség, gyorsabb a sebgyógyulás, a betegrehabilitáció, és az esetleges
immunológiai kilökődés lefolyása is enyhébb és jobban kezelhető. Orv Hetil.
2023; 164(28): 1087–1093.
Nulidad absoluta por falencia en la planeación contractual
Authors: Castillo Povea Eduardo , Páez Barros Jorge Enrique , Rodríguez Serpa Ferney Asdrúbal , De la Torre Soto Giselle Loren , Navarro-Beltrán Jorge
Published: July 2023

El Consejo de Estado de Colombia, a través de la sentencia CE SIII E 27315-2013 introdujo al ordenamiento jurídico una nueva causal de nulidad absoluta por objeto ilícito, la cual se genera por falencias en la planeación del contrato estatal. De acuerdo con la normatividad vigente, la planeación del proceso contractual le corresponde únicamente a la entidad contratante conforme a las leyes 80 de 1993, 1150 de 2007, 1474 de 2011, 1882 de 2018 y el decreto reglamentario 1082 de 2015. No obstante, el Consejo de Estado en la referida sentencia le asigna el deber de planeación al contratista, sin tener en consideración que el mismo no está obligado a realizar  dicha función en la etapa precontractual, como tampoco a subsanar defectos generados en la primera etapa de planeación, cuando aún no hay contratista porque el proceso de selección está en momentos previos a la expedición y publicación del acto administrativo de apertura del proceso, y donde solo hay potenciales proponentes, pero no contratista, que es a quien legalmente se le exige el deber de colaboración en la ejecución del contrato. Con la declaratoria de nulidad del contrato por objeto ilícito, se suspende la ejecución del mismo y el contratista debe asumir la pérdida de casi todos los recursos invertidos en la ejecución de la obra, lo cual equivale a decir, que por disposición judicial, el contratista sufre detrimento patrimonial, investigación penal, fiscal y afectación en su inscripción en el RUP porque el Estado contratante no cumple con el deber de correcta planeación, lo que constituye evidente injusticia para con el contratista.
De indeseables a agentes de progreso. Análisis historiográfico del proceso de integración de los árabes en Colombia
Authors: Diaz Rico Jhojan Alejandro
Published: July 2023

Analizo dos de las corrientes historiográficas que estudian la migración árabe a Colombia y su proceso de integración. La primera estudia dicho proceso a través de un lente económico, mientras la otra lo hace a través de una perspectiva racial. Pese a su importante contribución, estas líneas no sitúan sus interpretaciones en un escenario socio-racial amplio en el que las categorías racializadas fundamentaron un ideal de ciudadano moderno, blanqueado y económicamente productivo. Sugiero que estudiar el proceso de integración de los árabes a través de la categoría de ciudadanía permite unificar en una sola interpretación los argumentos económico y racial.
Formation of social communication skills among students of the Faculty of Medicine in the system of professional education. Experience of the Republic of Kazakhstan
Authors: Kidirbayeva K. , Satiyeva Sh , Kuanyshbayeva Zh , Iskakova A. , Assanova G. I. , Роvalyashko G. , Duisenbekova Zh.
Published: July 2023

The article describes the formation of social communication (SC) skills among healthcare professionals in order to determine its place in professional activities.

A theoretical analysis of the philosophical, pedagogical, psychological and scientific-methodical literature related to the problem under study was carried out. The national pedagogical experience in SC development was analyzed through the prism of cultural and moral patterns embedded in the national literature. The following methods were used: conversations with students, medical workers, discussion, survey.

According to the authors, the low interest in national literature and culture is a significant reason for the low level of SC skills among workers in the social and medical service and in professional group communication. A survey among students showed a low interest in the national cultural samples, including those expressed in national literature.

According to the authors, in the development of SC skills in future healthcare professionals, the experience of domestic pedagogy is of great importance, aimed at improving the moral education necessary for adequate behavior and communication, not only in the context of local and national realities, but also including respect for other cultures.
EXPERIMENTAL STUDIES ON VELOCITIES OF GAS- AND SOLID-PHASES IN GAS-LIQUID-SOLID THREE-PHASE FLOW FOR SUBSEA RESOURCE PRODUCTIONS
Authors: Takano Satoru , Masanobu Sotaro , Kanada Shigeo , Ono Masao
Published: July 2023

Subsea minerals and methane hydrates have been found in the deep-sea within Japan's exclusive economic zone, but they have not been commercialized owing to technical issues. Gas-lift pumping is a promising technique for transporting subsea minerals and methane hydrates from the seafloor to the surface. However, the internal flow within the pipes of a gas-lift pumping system often becomes a three-phase flow, so a method is needed for calculating the velocity of each phase. We reviewed
previous studies on the velocities of each phase in two- and three-phase flows, which we used to propose correlations for the velocities of the gas and solid phases.We then conducted experiments on gas-liquid two-phase and gas-liquid-solid three-phase flows through transparent polyvinyl chloride pipes using glass beads as solid particles. The experimental data suggests that the presence of the solid phase has little influence on the distribution parameters and drift velocity. In addition, the velocity of the liquid phase has a large influence on the velocity of the solid phase for the slug flow, and the velocity of the gas phase has a large influence on the velocity of the solid phase for the annular flow. We use the proposed correlations to calculate the velocities of each phase in a threephase flow and compare the results with the experimental data. The comparison shows that the proposed correlations can accurately calculate the velocities of the gas and solid phases.
Timber moisture content evaluation using spiral capacitive structures
Authors: Oommen Binu Ani , Philip Jacob , Oommen Binu Ani
Published: July 2023

In this work a transducer based on spiral planar inter-digital capacitive structure is designed and implemented for timber moisture content measurement. The sensor capacitance measured at frequency 100 KHz is found to depend strongly on the material dielectric properties, which is found to increase with increasing moisture contents (MC). The moisture contents in the range from 0% to 82% for 5 different varieties of timber specimens are measured and the results presented. The measured capacitances increase with moisture contents with an exponential fitting, with a correlation coefficient better than 0.98 indicating good fit for all the timber varieties. The sensitivity of the technique varies with the specimen as well as its moisture content. The best sensitivity obtained is 0.01 pF/MC%. The performance of the technique in terms of relevant sensor parameters has been analysed and compared with existing techniques for the same measurement. Although several moisture measurement methods exist for timber, the present inter-digital capacitive technique has many advantages over them in terms of sensitivity, dynamic range, cost effectiveness, non-invasiveness, non-destructiveness and measurement speed.
‘The Substance of Paint’: Class and Materiality in the Work of Ralph Balson
Authors: Cole Georgina O'Donnell , Haseman Shane Michael
Published: July 2023

Ralph Balson (1890–1964) was an English plumber and house painter who emigrated to Australia in 1913 and subsequently became a key member of Sydney’s artistic avant-garde. He is credited with having the first solo exhibition of purely abstract painting in Australia in 1941. Despite his role in developing Australian non-objective painting, Balson remained principally a house painter, working on his art practice at weekends. In 1955 he retired on a state pension and became a full-time artist.Balson’s artistic education and methods were critically shaped by his working-class background. He did not travel abroad until 1960 and was an avid auto-didact. His materials, palette, techniques and compositional strategies were likewise informed by his trade. Balson’s profession as a painter-decorator made him conspicuous within the predominantly middle-class Sydney art scene, though his painting partner Grace Crowley considered it an advantage in their pursuit of constructive painting. This paper explores the impact of Balson’s trade on his trajectory towards pure abstraction. While his art was at odds with the predominantly figurative mode of class-conscious art in Australian Modernism, we argue that it is embedded in the experience of class through its creative adaptation of labour into aesthetics.
Examining Aspects of Digital Inclusion Among National Samples of US Older Adults
Authors: Schuster Amy M. , Cotten Shelia R.
Published: July 2023

We live in a world where we are constantly connected to devices (e.g., smartphones, computers, tablets) and are encouraged to go online to find information about most things in society. This constant digital connection provides the means whereby many individuals communicate and exchange social support. For most demographic groups, this results in being online and connected to devices multiple times each day. Older adults have been slower to adopt and use emerging information and communication technologies (ICTs). Their digital divide in comparison to other age groups may not be an accurate representation of their technology use and the reasons for this use. This descriptive study examines this view of digital inclusion by focusing on older adults and their uses of technology. We provide an overview of technology usage by different older adult age groups in the United States using existing national‐level data. We utilize life course and aging theoretical perspectives to help articulate how older adults use a wide variety of ICTs and whether they are constantly connected, and we note that while a constant connection to devices may be normative for younger age groups, this may not, and perhaps should not, be the case for older adults. The article concludes with a discussion of the social construction of digital inclusion and emphasizes the significant variation that exists in this construct, measurement of technology use in large‐scale datasets, and variation in technology use across older adult life course groups.
Detection and Localization of Faults in a Regional Power Grid
Authors: Kokoszka Piotr , Rimkus Mantautas , Hosur Sanjay Sheshagiri , Duan Dongliang , Wang Haonan
Published: July 2023

The structure of power flows in transmission grids is evolving and is likelyto change significantly in the coming years due to the rapid growth ofrenewable energy generation that introduces randomness and bidirectionalpower flows. Another transformative aspect is the increasing penetrationof various smart-meter technologies. Inexpensive measurement devicescan be placed at practically any component of the grid. Using modeldata reflecting smart-meter measurements,we propose a two-stage procedure for detecting a fault in a regional powergrid. In the first stage, a fault is detected in real time. In the second stage,the faulted line is identified with a negligible delay. The approach uses onlythe voltage modulus measured at buses (nodes of the grid) as the input.Our method does not require prior knowledge of thefault type. The method is fully implemented in  R.Pseudo code and complete mathematical formulas are provided.
amIcompositional: Simple Tests for Compositional Behaviour of High Throughput Data with Common Transformations
Authors: Gloor Gregory Brian
Published: July 2023

Compositional approaches are beginning to permeate high throughput biomedical sciences in the areas of microbiome, genomics, transcriptomics and proteomics. Yet non-compositional approaches are still commonly observed. Non-compositional approaches are particularly problematic in network analysis based on correlation, ordination and exploratory data analysis based on distance, and differential abundance analysis based on normalization. Here we describe the aIc R package, a simple tool that answers the fundamental question: does the dataset or normalization exhibit compositional artefacts that will skew interpretations when analyzing high throughput biomedical data? The aIc R package includes options for several of the most widely used normalizations and filtering methods. The R package includes tests for subcompositional dominance and coherence along with perturbation and scale invariance. Exploratory analysis is facilitated by an R Shiny app that makes the process simple for those not wishing to use an R console. This simple approach will allow research groups to acknowledge and account for potential artefacts in data analysis resulting in more robust and reliable inferences.
Adherence to Medications in Patients with Ischaemic Heart Disease in Oman
Authors: Al-Maskari Ahmed , Al-Maamari Qasim , Al-Abdali Mariya , Al-Shaaibi Hajer , Nadar Sunil K
Published: July 2023

Objectives: This study aimed to evaluate the level of adherence to medication among patients with ischaemic heart disease (IHD) in Oman and assess the related factors. Methods: This cross-sectional questionnaire-based study among patients with IHD attending the outpatient clinic at Sultan Qaboos University Hospital, Muscat, Oman, was performed between January and December 2021. Results: A total of 105 patients (mean age = 49.9 ± 11.1 years, 78.1% male) were recruited. Most of the patients (80%) reported taking the medications by themselves; 77 (73.3%) patients said that over the preceding 2 weeks, they had missed at least 3 doses of their medication. The reasons for missing the medications included forgetting (100%), having to take too many tablets (57%), feeling that the tablets are not effective (48%) and having to take the tablets too often each day (23%). The factors responsible for patients failing to take medications could not be identified. Conclusion: Medication adherence was low among patients with IHD in Oman, with high pill burden being the most common reason for non-adherence. Physicians must bear this in mind when reviewing patients.
Keywords: Cardiovascular Disease; Medication Adherence; Myocardial Infarction; Oman.
Efficacy of Ropivacaine for Sub-Arachnoid Block in Patients with Recent History of Scorpion Sting
Authors: Trivedi Saurabh , Bhardwaj Hemendra , Sahoo Tapan K , Gupta Seema
Published: July 2023

Failure of sub-arachnoid block (SAB), due to resistance to bupivacaine after a recent scorpion sting can lead to multiple block attempts and subsequent conversion to general anaesthesia. We report this case series of 10 patients with successful SAB with newly launched 0.75% hyperbaric ropivacaine, in patients with recent scorpion sting. Thus, intrathecal hyperbaric ropivacaine may be considered as the local anaesthetic agent of choice in patients with scorpion sting to prevent failure of SAB.
Keywords: Bupivacaine; Ropivacaine; Scorpion Stings; Spinal Anaesthesia.
Where are the Roman women of Ovilava? A spatio-temporal approach to interpret the female deficit at the eastern Roman cemetery (Gräberfeld Ost) of Ovilava, Austria
Authors: Hagmann Dominik , Ankerl Barbara , Greisinger Michaela , Miglbauer Renate , Kirchengast Sylvia
Published: July 2023

In historic and prehistoric populations, the sex ratio can often only be determined based on bioarchaeological analyses of cemeteries. In this context, a so-called female deficit has been described, which clearly contrasts the sex ratio typical of recent populations. The present study aims to analyze the sex ratio in the eastern cemetery (‘Gräberfeld Ost’) of the Roman town Ovilava. This site is located beneath today’s city of Wels in Upper Austria (AUT), in the northwestern region of Noricum. Spatial as well as chronological aspects of the sex ratio were considered. A total of 111 individuals older than 15 years could be included in the analysis. Radiocarbon dating allowed a chronological classification of the burials. In addition, a spatial analysis of the cemetery was carried out using a geoinformation system. For the whole sample, a sex ratio of 200.0 and a marked female deficit were recorded. Considering the individual age classes and the periods separately, an apparent female surplus emerged among individuals younger than 20 years (sex ratio = 62.5). With increasing age class, the proportion of females reduced dramatically; among the over 40-year-olds, the sex ratio was 370.0. There was also an apparent female deficit in the Early Roman and Imperial Roman Periods but an almost balanced sex ratio in the early Middle Ages. Furthermore, the sex proportion varied between the cemetery areas. Consequently, a female deficit occurs mainly during Roman times and in specific areas of the burial ground.
Żydowski Obwód Autonomiczny na Syberii. Wielokulturowe dziedzictwo i współistnienie
Authors: Vitale Alessandro
Published: July 2023

Formalnie rzecz biorąc, Izrael nie jest jedyną oficjalną ojczyzną Żydów na świecie. W azjatyckiej części Rosji, na Syberii, nadal istnieje Żydowski Obwód Autonomiczny w Birobidżanie. Począwszy od 1928 r. Związek Radziecki przeznaczył na osiedlenie Żydów terytorium większe niż Belgia i Holandia razem wzięte i znacznie większe niż Izrael, usytuowane ponad 6 tys. km na wschód od Moskwy, wzdłuż granicy rosyjsko-chińskiej, pomiędzy 48 i 40 stopniem szerokości północnej, gdzie klimat i warunki są podobne do Ontario i Michigan. Wierząc, że Żydzi rosyjscy, podobnie jak inne mniejszości narodowe, zasługują na własne terytorium, reżim sowiecki zdecydował ustanowić terytorium, które w 1934 r. stało się Żydowskim Obwodem Autonomicznym. Ideą było utworzenie Nowego Syjonu – jako przeciwwagi do Palestyny – gdzie „proletariacko-żydowska kultura”, oparta na języku jidysz, mogła się rozwijać. W rzeczywistości ustanowienie Żydowskiego Obwodu Autonomicznego było w pierwszym rzędzie oficjalnym uznaniem narodowego terytorium Żydów od czasów starożytnych: „Pierwszego Izraela”. Ale historia tego regionu była tragiczna i eksperyment nie powiódł się. Jednakże odnowione dzisiaj istnienie Birobidżanu i odrodzenie żydowskiego życia w posowieckim Żydowskim Obwodzie Autonomicznym są nie tylko ciekawym spadkiem po sowieckiej narodowej polityce, ale też po rozpadzie Związku Radzieckiego, i religijnym odrodzeniu na świecie; tym samym stanowią interesujące studium przypadku do badań niektórych ambitnych problemów geograficznych i stosunków międzyetnicznych.
Socio-economic Correlation of Technology Know-how of Farm Entrepreneurs of Samastipur District of Bihar, India
Authors: Kumari Pushpa
Published: July 2023

Background: In the process of agricultural development, the prime mover is considered to be the new farming technology. Technology plays a pivotal role in every aspect of the agricultural phenomenon. It enhances productivity and transparency at every step of agricultural movements. Quality and quantity are managed through this facility which improves farmers’ socioeconomic status and mental health. From this perspective, technological involvement must be necessary with the human values. Methods: The study was conducted during 2019-21 to identify the role of different socio-economic variables and their correlation to the technology know-how of farm entrepreneurs of the Samastipur district of Bihar, India. Knowledge of the improved farm technology possessed by the farmers was considered a dependent variable and 17 socioeconomic and psychological variables were considered independent variables. Result: It was concluded from the study that variables like material possession of higher assets and more investment in irrigation were found to dominate in respect of the acquisition of knowledge about farm technology. Lack of formal education on the part of the farmers did not impede their acquisition of knowledge of the farm technology through available sources of communication. The human resources variables were found to influence the acquisition of knowledge by the respondents.
Non-kinship foster care in Nigeria: Socioeconomic and demographic drivers of mothers’ willingness to foster
Authors: Isangha Stanley Oloji , Yinka Akintunde Tosin , Cherry Hau Lin Tam , Wai Man Choi Anna
Published: July 2023

Research in Africa indicates an increasing number of children needing a secure and stable alternative family environment, yet the commonly used kinship care system is insufficient to meet this need requiring the support of non-kinship care. This study examined the socioeconomic and demographic drivers of willingness to foster non-kin children among mothers in Nigeria. Data from 779 mothers of children ages 2-10 were analyzed using Pearson correlation matrix and linear regression analysis to examine the associations among socioeconomic/demographic characteristics and willingness to foster. Attributes of the mothers such as region, neighborhood (rural or urban), education, occupation, and age are some determinants of willingness to foster, which also varies across children with special needs, diversity, and under six. Efforts to improve non-kinship foster care in Nigeria should consider mothers’ socioeconomic and demographic attributes when seeking to attract foster parents. The findings of this study provide implications for research, social work practice, and education in Nigeria and Africa.
Direct construction of d3-methylated all-carbon quaternary stereocenters through carbene-catalyzed desymmetrization
Authors: Guo Jingcheng , Zhang Ye , Zhang Xiaoxiang , Fu Zhenqian
Published: July 2023

The construction of d 3 -methylated all-carbon quaternary stereocenters has been successfully developed via carbene-catalyzed desymmetrization of prochiral d 3 -methylated oxindolyl 1,3-diketones. Three new stereogenic centers were efficiently constructed with satisfactory outcomes. Diverse spiro-polycyclic molecules with a d 3 -methylated all-carbon quaternary stereocenter were generated in good to excellent yields with good to excellent diastereoselectivities and excellent enantioselectivities. This reaction features a broad substrate scope, good functional-group tolerance, and easy scale-up.
Can We Predict Prostate Cancer Metastasis Based on Biomarkers? Where Are We Now?
Authors: San Francisco Ignacio F , Rojas Pablo A , Bravo Juan C , Díaz Jorge , Ebel Luis , Urrutia Sebastián , Prieto Benjamín , Cerda-Infante Javier
Published: July 2023

Background: The incidence of prostate cancer (PC) has been risen annually. Despite the diagnosis is made mainly with non-metastatic PC, mortality is explained by the metastatic disease (mPC). Without a doubt there is an intermediate scenario in which patients have no mPC but will have initiated a metastatic cascade through an epithelial-mesenchymal transition. There is indeed a need for more and better tools to predict what patients will progress in the future to non-localized clinical disease or already have micrometastatic disease, and therefore, will clinically progress after primary treatment. Biomarkers for predicting mPC are still under development; there are few studies and not much evidence of their usefulness. Summary: This review is focused on tissue-based genomic biomarkers (TBGB) for predicting metastatic disease. We developed four main research questions that will attempt to answer according to the current evidence. Why is important to predict metastatic disease? Which tests are available to predict metastatic disease? What impact should there be on clinical guidelines and clinical practice in predicting metastatic disease? What are current prostate cancer treatments? Key Messages: Knowing useful predict tools could help determine which patients may need multimodal or adjuvant treatment even with a localized disease, and in consequence, what patients do not need more than a single modality of treatment. The importance of predicting metastasis is fundamental, given that once metastasis is diagnosed, the quality of life (QoL) and survival drop dramatically.
On Structural Sensitivity Of Young’s Modulus Of Ni-Rich Ti-Ni Alloy
Authors: Ryklina Elena , Murygin Semen , Komarov Victor , Polyakova Kristina , Resnina Natalia , Andreev Vladimir
Published: July 2023

When developing bone implants Young's modulus is one of the primary characteristics of the material that should be considered. The study focuses on the possibility of regulating the modulus of the alloy Ti-50.8 at % Ni by varying its initial structure as well as aging-induced microstructure in a wide range. Microstructure observations were performed using TEM and SEM observations. The calorimetric studies of martensitic transformations were carried out using "Mettler Toledo 822e". Tensile tests were performed in a test temperature range of ‒196≤T≤+100°C using an «IN-STRON 5966». The grain/subgrain size of B2-austenite strongly affects the modulus magnitude. This effect is ambiguous for a material with a grain size of 0.13–3 µm and depends on the test temperature. The effectiveness of aging on the modulus reduction depends on the initial structure: it is most pronounced in an alloy with a relatively coarse grain size of 9 µm and brings a decrease by 3.8 times at a temperature of 37°C. Bone-like elastic modulus (10–30 GPa) at a human body temperature of 37°C is realized in an aged fine-grained NiTi alloy. An ultrafine-grained sub-structure exhibits he same values of Young's modulus in the temperature range from -100°С to 25°С.
Optimised Structural Modelling For Inverse Analysis Parameter Identification Relying On Dynamic Measurements
Authors: Cornaggia Aram , Garbowski Tomasz , Cocchetti Giuseppe , Ferrari Rosalba , Rizzi Egidio
Published: July 2023

In the context of Inverse Analysis in Civil Engineering, parameter identification and model calibration, of a structural system, relying on dynamic measurements, are subjects of a growing research interest. In the present contribution, the topic is tackled with reference both to simplified structural numerical examples and to a specific case study, namely a historical road three-span reinforced concrete arched bridge, with vibrational data previously acquired by standard wired accelerometers on the deck, under operational traffic conditions. In particular, the present work aims at focussing on the identification issues, concerning the definition of a maximum allowable threshold number of sought material parameters (e.g., Young’s moduli and mass densities of different structural components), with respect to the amount of available measurement data, and the investigation of the inverse analysis discrepancy function to be optimised, in order to set the intrinsic issue of multiple “realizations”, in case of a plain use of modal properties, and in view of forming a well–posed optimisation problem. Structural modelling, sensitivity analysis and numerical optimisation approaches are herein combined toward a robust and efficient identification strategy, to be effectively employed in structural assessment and diagnosis, also with respect to originally available or enriched sets of experimental data. The proposed methodology, and collected results, shall outline an efficient identification procedure, in view of automated inverse analysis, practically oriented to the dynamic assessment and structural diagnosis in the Civil Engineering context, as applied e.g. to strategic bridge infrastructures.
Nutritional Status of Kidney and Pancreas Transplant Candidates - Experience of the One Polish Transplant Center (Observational Study)
Authors: Kędzierska-Kapuza Karolina , Niewiński Grzegorz , Durlik Marek , Wierzba Waldemar , Szczuko Małgorzata
Published: July 2023

Pancreas transplantation is a high-risk operation that requires significant skill and expertise from the surgeons and the postoperative care team. Prior to candidate qualification, all contraindications to this procedure must be excluded. The use of screening tools and nutritional assessment aims to emphasize the importance of accurately diagnosing nutritional status in order to implement early nutritional interventions and reduce complications associated with malnutrition. This plays a crucial role in improving postoperative outcomes for patients undergoing pancreas and/or kidney transplantation.
Objective: The aim of this study was to analyze the parameters of nutritional status in patients eligible for kidney transplantation and kidney with pancreas transplantation.
Methods: The study analyzed the database of hospitalized patients in our Center from 2020 to 2023 to identify preoperative parameters of nutritional status in patients eligible for kidney transplantation (Ktx) and kidney with pancreas transplantation (SPKTx).
Participants: A total of 59 patients participated in the study, who were candidates for kidney transplantation (23, including 11 females and 12 males) or kidney with pancreas transplantation (36, including 24 females and 12 males).
Parameters examined included: Onoder's Prognostic Nutritional Index (PNIO), Nutrition Risk Index (NRI), ideal body weight (IBW) calculated using the Lorenz formula, and the neutrophil-to-lymphocyte ratio (NLR). All patients admitted to the clinic underwent the NRS-2002 clinical assessment scale for nutritional status.
Results: Upon analyzing the obtained results, it was found that BMI was not a good differentiating parameter for the studied groups. The PNIO index also insufficiently differentiated the studied groups, and similarly, the NRI index was a weak differentiating parameter. The NRS-2002 index and albumin level were the best indicators of differences between the groups. In the group of transplantation candidates, several parameters indicated that patients in the Ktx group (kidney transplantation candidates) had better nutritional status than SPKtx candidates (kidney with pancreas transplantation candidates), despite the former group being older patients.
Conclusion: It seems that more effort should be made to start a proper nutrition plan for SPKTx (and especially peritoneal dialysis) patients. Regular assessment of nutrition status should be performed. SPKtx patients in the perioperative period should receive parenteral nutrition and, as soon as their general condition allows it, enteral nutrition, taking into account the caloric and protein needs
Key Nutrients for Optimal Blood Glucose Control and Mental Health in Individuals With Diabetes: A Review of the Evidence
Authors: Basiri Raedeh , Seidu Blessing , Cheskin Lawrence J.
Published: July 2023

Nutrition, diabetes, and mental disorders are interconnected and significantly impact an individual's overall health and well-being. This comprehensive review aims to explore the complex interplay between nutrition, diabetes, and mental disorders, highlighting the latest research findings in this field. While the influence of nutrition on the development and management of both diabetes and mental disorders is widely recognized, there remains a gap in understanding the intricate interplay between nutrition, mental health, and diabetes. Diabetes is associated with an increased risk of mental disorders, including depression, anxiety, and cognitive decline. Mental disorders can also contribute to the development of diabetes through various mechanisms including increased stress, poor self-care behaviors, and adverse effects on glucose metabolism. Thus, the mechanisms linking nutrition, diabetes, and mental disorders are complex and multi-factorial. Inflammation, oxidative stress, gut microbiota alterations, and neuroendocrine dysregulation have emerged as potential pathways that may mediate the relationship between nutrition, diabetes, and mental disorders. Additionally, deficiencies in essential nutrients such as omega-3 fatty acids, vitamin D, B vitamins, zinc, chromium, magnesium, and selenium have been implicated in the pathogenesis of both diabetes and mental disorders. Our findings indicate that the use of personalized dietary interventions and targeted nutrient supplementation can improve metabolic and mental health outcomes in patients with type 2 diabetes.
Best Possible Medication History Collection by Clinical Pharmacist in a Perioperative Setting: An Observational Prospective Study
Authors: Mengato Daniele , Pivato Lisa , Codato Lorenzo , Faccioli Fabiola Fernanda , Camuffo Laura , Giron Maria Cecilia , Venturini Francesca
Published: July 2023

Background: Best Possible Medication History (BPMH) collected by clinical pharmacists is crucial for effective medication review but, in Italy, it is often left to the nursing staff. This study aims to compare the quality and accuracy of a clinical pharmacist-documented BPMH with the current standard practice of ward staff-collected BPMH at an Italian perioperative surgical setting. Methods: A 20-week prospective observational non-profit study was conducted in a major University hospital. The study comprised a feasibility, an observational, and an interventional phase. During the feasibility phase, 10 items for obtaining a correct BPMH were identified. The control group consisted of retrospectively analyzed BPMHs collected by the ward staff during the observational phase, while interventions included BPMHs collected by the clinical pharmacist during the third phase. Omissions between the two groups were compared. Results: 14 (2%) omissions were found in the intervention group, compared with 400 (57.4%) found in the controls (p<0.05); data collection was more complete when collected by pharmacists compared to the current modalities (98.0% versus 42.6%; p<0.05). Conclusions: The involvement of a pharmacist significantly reduced the number of omissions in perioperative surgical-collected BPMHs. This intervention holds the potential to decrease the risk of medication errors associated with inaccurate or incomplete BPMHs prior to surgical hospitalization.
Aldehyde Dehydrogenase Genes as Prospective Actionable Targets in Acute Myeloid Leukemia
Authors: Dancik Garrett M. , Varisli Lokman , Tolan Veysel , Vlahopoulos Spiros A
Published: July 2023

It has been previously shown that aldehyde dehydrogenase (ALDH) family member ALDH1A1 has a significant association with acute myeloid leukemia (AML) patient risk group classification, and that AML cells lacking ALDH1A1 expression can be readily killed by chemotherapy. In the past, however, a redundancy between the activities of subgroup members of the ALDH family has hampered conclusive evidence for addressing the role of specific ALDH genes. We here describe the bioinformatics evaluation of all nineteen member genes of the ALDH family as prospective actionable targets for the development of methods aimed to improve AML treatment. We implicate ALDH1A1 in the development of recurrent AML, and we show that from the nineteen members of the ALDH family, ALDH1A1 and ALDH2 have the strongest association with AML patient risk group classification. Furthermore, we discover that the sum of the expression values for RNA from the genes ALDH1A1 and ALDH2 has a stronger association with AML patient risk group classification and survival than either one gene alone. In conclusion, we identify ALDH1A1 and ALDH2 as prospective actionable targets for the treatment of AML in high risk patients. Substances that inhibit both enzymatic activities can constitute potentially effective pharmaceutics.
Nuclear Morphofunctional Organization and Epigenetic Characteristics in Somatic Cells of Triatoma infestans (Klug)
Authors: Mello Maria Luiza S.
Published: July 2023

Triatoma infestans (Klug) is an insect recognized as not only an important vector of South-American trypanosomiasis (Chagas disease) but also a model of specific cellular morphofunctional organization and epigenetic characteristics. The purpose of the present review is to highlight certain cellular processes that are particularly unveiled in T. infestans, such as 1) somatic polyploidy involving nuclear and cell fusions that generate giant nuclei; 2) diversification of nuclear phenotypes in the Malpighian tubules during insect development; 3) heterochromatin compartmentalization into large bodies with specific spatial distribution and presumed mobility in the cell nuclei; 4) chromatin remodeling and co-occurrence of necrosis and apoptosis in the Malpighian tubules under stress conditions; 5) epigenetic markers; 6) unexplained response of heterochromatin to valproic acid, an epidrug that inhibits histone deacetylases and induces DNA demethylation in other cell systems. These cellular processes and epigenetic characteristics emphasize the role of T. infestans as an attractive model for cellular research.
Bio-Production of Fermented Dairy Products and Health Benefits: A Review Ofthe Current Scenario and Prospects
Authors: Rajta priyanjali , Bajaj Anjali , Sharma Shaina , Regassa Hailemeleak , Gudeta Kasahun
Published: July 2023

The quality and safety of fermented milk products, which make up a sizeable portion of human nutrition, are greatly influenced by both the milk itself and the starting cultures employed to ferment it. Lactic acid bacteria (LAB) create a variety of metabolites throughout the fermentation process, altering the organoleptic properties of the substrates. The final product’s nutritional value and digestibility are enhanced by fermentation of the raw materials, which also adds vitamins, vital amino acids, and fatty acids. The quality and safety of fermented milk products, which make up a sizeable portion of human nutrition, are greatly influenced by both the milk itself and the starting cultures employed to ferment it. The inhibition of the growth of pathogenic microbes, which lowers the likelihood of the emergence of foodborne diseases, is another crucial function of LAB. A variety of pathogenic bacteria are frequently present in raw (unpasteurized) milk, and other raw materials; these pathogenic bacteria should be removed during the fermentation process. As a result, a variety of LAB metabolites, such as hydrogen peroxide, organic acids, and bacteriocins, function as bio preservative agents, enhancing food safety and lengthening the shelf life of the finished products.
Bending Stiffness of Unsymmetrical Multilayered Corrugated Board: Influence of Boundary Conditions
Authors: Mrówczyński Damian , Pozorska Jolanta , Garbowski Tomasz , Pozorski Zbigniew
Published: July 2023

In the laboratory practice, several standards for testing the bending stiffness of corrugated board are used. There are often cases of tests where the results depend on the way the sample is placed on the supports. The problem arises when the board is five-ply (with two corrugated layers with different corrugation heights) or when the board has asymmetrically selected papers on the flat layers. In this article, we focus our attention on the problem related to boundary conditions, with particular attention to the local effects of the support of the sample. Since the cardboard layers, both flat and corrugated, have a small thickness, a slight deformation of the papers can always be observed at the point of contact between the sample and the support, which affects the readings of the measured stiffness. The paper presents theoretical and numerical analyzes showing how much the method of supporting the sample affects the measured bending stiffness of various samples. Numerical observations were also compared with the results of analyzes presented by other scientists as well as with experimental results.
Physics-Based Swab and Surge Simulations and Machine Learning Modelling of Field Telemetry Swab Dataset
Authors: Mohammad Amir , Agonafir Mesfin Belayneh , Davidrajuh Reggie
Published: July 2023

Drilling operation is the major cost factor for the industry. Appropriately designed operations are essential for successful drilling. Optimized drilling operations also allow enhanced drilling performance and reduce the drilling cost. This is achieved by increasing the bit life (minimizing premature bit wear), drilling faster that allows reducing drilling time, and also reducing tripping operations. The paper presents two parts. The first part compares the parametric physic-based swab and surge simulation results obtained from Bingham Plastic, Power Law, and Robertson and Stiff models. The aim is to show how the model predictions deviate from each other. Two 80-20 Oil Water ratios (OWR) and two 90-10 OWR oil-based drilling fluids with 1.96 sg and 2.0 sg were considered in vertical- and deviated wells. Simulation results analysis revealed that the deviations depend on the drilling fluid’s physical and rheological parameters as well as the well trajectory. Moreover, the model’s predictions were inconsistent. Data-driven machine learning (ML) modeling makes up the second section. Data-driven modeling was done using both software-generated datasets and field datasets. Results show that the Random Forest Regressor (RF), Artificial Neural Network (ANN), Long Short-Term Memory (LSTM), LightGBM, XGboost, and Multivariate regression models predict the training and test datasets with higher R-squared and minimum root means square values. Deploying the ML model in real-time applications and the planning phase would have the potential application of artificial intelligence for well planning and optimization processes.
Properties of Superelastic Nickel-Titanium Wires After Clinical Use
Authors: Alcaraz Inés , Moyano Javier , Pàmies Ariadna , Ruiz Guillem , Artés Montserrat , Gil Xavier , Puigdollers Andreu
Published: July 2023

The aim of the present study was to describe and determine changes in the superelastic properties of NiTi archwires after clinical use and sterilization. Ten archwires from five different manufacturers (GAC, 3M, ODS, GC, FOR) were cut in two segments and evaluated using a three-point bending test in accordance with ISO 14841:2006. The centre of each segment was deflected to 3.1mm and then unloaded to 0 N to obtain a load-deflection curve. Deflection at the end of the plateau and forces at 3, 2, 1 and 0.5mm on the unloading curve were recorded. Plateau slopes were calculated at 2, 1 and 0.5mm of deflection. Data obtained were statistically analysed to determine differences (p<0.001). Results showed that the degree of superelasticity and exerted forces differed significantly among brand groups. After three months of clinical use, FOR released a greater force for a longer activation period. GC, EURO and FOR archwires seemed to lose their mechanical properties. GC wires released more force than other brand wires after clinical use. Regarding superelasticity after sterilization, GAC, 3M and FOR wires recovered their properties, while EURO archwires lost more.