bluuebunny/crossref_metadata_2025 huggingface dataset:
Neutrophil Lymphocyte Rate: A Marker of Mortality and Prognosis for Covid-19?
Authors: TEKİN Selda , ŞEN Erman , Adıyeke Esra , COŞKUN Nilüfer , Sarı Özgün Topçuoğlu , BAKAN Nurten
Published: September 2021

Objective: In recent years, the neutrophil-to-lymphocyte ratio (NLR) has become a parameter sought in the prediction of aggressive prognosis or mortality in many studies including sepsis, infectious diseases, and malignancies. There are publications studying the correlation between the high values of this parameter, which can be interpreted as an indirect indicator of the host’s immune response, in the COVID-19 infection with mortality. The primary objective of our study is to evaluate the correlation between the height of NLR values in the patients followed up in our intensive care units (ICU) with the final diagnosis of COVID-19 infection (PCR(+)), the continuation of such high values throughout the treatment and mortality, and finally obtain a cut-off value in predicting the prognosis.
Method: The case files with final diagnosis of COVID-19 infection followed up and treated in our 3rd Level Intensive Care Unit from 21 March 2020 to 1 July 2020 were screened retrospectively and included in the study. These cases were examined in two groups: exitus (n=113) and survivors (n=70). The demographics of the cases such as age, gender, comorbid diseases as well as their vital signs and clinical and laboratory features were screened from the Hospital Operating System (HOS) and archive files, and recorded. The correlation among the data obtained as well as the correlation between such data and mortality were analyzed.
Findings: In the study conducted on 183 cases, the ages, APACHE II scores, admission NLR values, study endpoint NLR values, neutrophil, procalcitonin, D-dimer, PT and INR levels, and MV (Mechanical Ventilation) durations of the exitus cases were found statistically significantly higher than the survivor cases. In the exitus cases, the cut-off point found for the admission NLR was >7.82. During the course of treatment, the patients with high NLR level had poor prognosis. The patients’ NLR values at the study endpoint were analyzed. The conclusion is that >6 as the cut-off point value is significant from the viewpoint of mortality. In addition, it was observed that a NLR level over 6 despite the treatment increased the mortality rate by 15.6 times. Conclusion: We have found out that old age, long MV duration, prolonged high levels of D-dimer, neutrophil, PT, INR and NLR levels increase the mortality rate. Being able to predict the course of prognosis and using early warning systems will increase the survival rate. In this regards, we consider closer monitoring of the patients with high NLR level, particularly in the intensive care units even if they do not have respiratory distress, will decrease mortality significantly. NLR can help identifying the COVID-19 patients with high risk level. High NLR level during the intensive care monitoring process may be regarded as insufficient immune response, and thus correlated with mortality and aggressive prognosis.
“A Study of Clinical and Ultrasonographic Findings of Patients Presented With Breast Pain”
Authors: Rahman Waliur , Sume Shireen jabeen , Yasmin Shamima
Published: September 2021

Introduction: Breast pain also known as mastalgia is the dull acne in the breast, cause is multifactorial. It can affect any age group. Breast cancer is the most common site-specific cancer in women and is the leading cause of death from cancer for women aged 20-59 years worldwide. In India, breast cancer has ranked number one cancer among females, with age adjusted incidence as high as 25.8 per 100,000 women and mortality 12.7 per 100,000 women.  Objective: To find out the Clinical and USG Findings of Patients Presented with Breast Pain.  

Settings and Design: Prospective cross-sectional descriptive study.  

Materials and Methods: Patients with complaints of breast pain in the age group 15 to 60 years with clinically no palpable mass attending to the Dept. of General Surgery, Chuadanga Sadar Hospital, Chuadanga, Bangladesh between January 2020 to December 2020 were included in the study. Detailed history with particular reference to age, duration of symptoms, Size, menstruation, marital status, parity, lactation, Nipple discharge and tenderness are recorded. Pain intensity was evaluated as mild, moderate and severe. Ultrasound of the breast including the axilla was done for all cases and findings recorded to correlate with clinical features.

Results: Out of 90 patients studied, majority was in the age group (21-30) years, (43%) followed by (31-40 years) (40%) respectively. 57(63%) were married and 33(43%) were single. 21 patients had 1 child, 18 had 2 children with 6 of them having no children. Out of 90 patients only 3 attained menopause, rest of them have their monthly cycles. 51 patients had cyclical breast pain and 39 had noncyclical breast pain, 39 had pain on right breast, 36 on left side and bilateral in 15 patients. Pain was mild in 15 patients, moderate in 27 patients and severe in 6 patients. Various USG findings of the affected breast were normal study in 48 patients followed by duct ectasia and hetrogenous ectogenicity fibroadenosis, small cystic lesion and enlarged axillary lymph nodes etc.

Conclusion: The study results show that majority of patients with breast pain without clinically palpable lump had normal USG study. But it also detects other early changes in the breast tissue. It can be used as a baseline investigation for any breast pain without palpable lump.
Estimation of the equality of the beamless sucker-rod oil pumping unit by the value of the consumption current
Authors:   Department of Machine Design of Azerbaijan Technical University, Ahmedov Beyali , Hajiyev Anar ,   Department of Machine Design of Azerbaijan Technical University, Mustafayev Vugar ,   Department of Mechanics of Mingachevir State University
Published: September 2021

The article presents the results of experimental studies to assess the loading and balancing of a new constructive solution of beamless sucker-rod pumping units. It is noted that the key factor that has the most significant effect on the mean time between failures (MTBF) is the right balancing of the pumping unit. The main purpose of the balancing device is the accumulation of potential energy during the downstroke and its release during the upstroke of the rod. It has been proved that the proposed additional balancing system (movable counterweight) which helps to reduce the uneven load on the electric motor and the power consumption of the pumping unit will also increase the efficiency of the beamless sucker-rod pumping unit. It was found that losses in sucker-rod pumps depend on the degree of balance of the counterweights. If the unbalance coefficient of the equipment is in the range from –5 to +5%, then the power loss due to unbalance can be ignored. In the current article, the authors propose a technique that allows to determine the energy characteristics of the electric drive of the pumping unit under conditions of a cyclically changing load and insufficient balance. It was revealed that when the balancer head passes from the upstroke to the downstroke and vice versa, there are sections with a negative value of the torque, which is explained by the influence of the inertial forces of the moving masses. This leads to shocks in the gearing of the reducer at the extreme positions of the cranks, increased wear and possibly to breakage of the teeth. Since it is not possible to completely eliminate this phenomenon, one should strive to limit the value of the negative torque by the correct balancing of the sucker-rod pump. In all cases, the change in the operating mode of a new constructive solution of beamless pumping unit requires new calculations, and requires changing the position and weights of movable and rotary counterweights (with combined balancing).
Nowoczesne technologie wiercenia kierunkowego wykorzystane przy wierceniu intersekcyjnego układu otworów
Authors:   Polskie Górnictwo Naftowe i Gazownictwo SA, Oddział Geologii i Eksploatacji w Warszawie, Ćwik Maciej ,   AGH Akademia Górniczo-Hutnicza im. St. Staszica, Wydział Wiertnictwa, Nafty i Gazu, Adamiak Jacek ,   Polskie Górnictwo Naftowe i Gazownictwo SA, Oddział Geologii i Eksploatacji w Warszawie,   AGH Akademia Górniczo-Hutnicza im. St. Staszica, Wydział Wiertnictwa, Nafty i Gazu, Kępiński Michał ,   Polskie Górnictwo Naftowe i Gazownictwo SA, Oddział Geologii i Eksploatacji w Warszawie,   AGH Akademia Górniczo-Hutnicza im. St. Staszica, Wydział Wiertnictwa, Nafty i Gazu
Published: September 2021

Artykuł dotyczy wykorzystania technologii wiercenia otworów kierunkowych – tzw. intersekcyjnych, które Polskie Górnictwo Naftowe i Gazownictwo SA wykonało w ramach prac badawczych prowadzonych w latach 2016–2021. Projekt miał na celu wykorzystanie nowoczesnych technologii w próbach rozpoznania złóż niekonwencjonalnych – formacji węglowych o niskiej przepuszczalności i niskim ciśnieniu złożowym, otworami wierconymi z powierzchni na terenie Górnośląskiego Zagłębia Węglowego. Przedstawiono zasadę gromadzenia się gazu w węglu (zjawisko adsorpcji opisywane modelem Langmuira) oraz sposób eksploatacji przez odwrócenie tego zjawiska i doprowadzenie do desorpcji przy wykorzystaniu odwadniania górotworu przez pompę zamontowaną w otworze pionowym poniżej intersekcji z otworem poziomym (horyzontalnym). Wyjaśniono celowość wiercenia otworu z odcinkiem horyzontalnym jako sposób zwiększenia strefy drenażu formacji produktywnej. W artykule zwrócono uwagę na zagadnienia związane z mechaniką górotworu, a dokładnie z określeniem kierunków naprężeń jako kluczowego parametru przy ustalaniu trajektorii otworów, które mają podlegać szczelinowaniu hydraulicznemu. Orientacja otworu prostopadle do kierunku maksymalnych naprężeń SHmax pozwala osiągać maksymalną wielkość stymulowanej strefy przyodwiertowej podczas zabiegu intensyfikacyjnego. Kluczowym fragmentem artykułu jest opis prac związanych z projektowaniem, a następnie wykonaniem systemu przecinających się (intersekcyjnych) otworów kierunkowych. Pionierskość omawianego projektu polegała zarówno na zastosowaniu technologii namierzania magnetycznego (ang. active magnetic rangening), jak i na wierceniu systemu otworów z jednego „placu” w sąsiedztwie dodatkowego otworu (również intersekcyjnego z otworem pionowym). Wykorzystane technologie wiercenia RSS (ang. rotary steerable system) pozwoliły na zrealizowanie zaprojektowanych trajektorii otworów i trafienie narzędziem o średnicy 6 cali w rurę z włókna szklanego o średnicy 7 cali na głębokości około 850 metrów. We wnioskach autorzy podkreślają innowacyjność wykonanych prac, zarówno w skali firmy, kraju, jak i światowej. Podają również przykłady zastosowania wykorzystanych technologii. Wart podkreślenia jest fakt, że wykonalność zaprojektowanych prac badawczych została potwierdzona w zastosowaniu przemysłowym.
Wykorzystanie czujników korozymetrycznych w ocenie skuteczności ochrony katodowej
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Minor Tomasz
Published: September 2021

Prawidłowa ocena skuteczności ochrony katodowej konstrukcji ułożonych w gruntach jest trudna, a jej skomplikowanie uzależnione jest od badanego obiektu. Jednymi z najbardziej trudnych do oceny obiektów są obiekty złożone, do których można zaliczyć między innymi: magazyny gazu wraz z orurowaniem, tłocznie gazu, stacje rozdziału gazu, zespoły przyłączeniowe tłoczni, kopalnie gazu itp. Chroniona infrastruktura podziemna obiektów złożonych często połączona jest z dużą ilością taśm uziemiających (kilka kilometrów), dużą ilością żelbetu oraz inną infrastrukturą podziemną, czego efektem są pojawiające się w ziemi prądy wyrównawcze, ogniwa korozyjne. W takich przypadkach dla poprawnej oceny skuteczności ochrony katodowej należy zastosować kilka technik pomiarowych, wykorzystując dodatkowe urządzenia pomiarowe. W artykule opisano metody wykonywania pomiarów skuteczności ochrony katodowej oraz korozymetrii rezystancyjnej, jako uzupełnienie podstawowej diagnostyki. Na podstawie badań terenowych wykonywanych w okresie około 5 lat przedstawiono przypadki, w których wyniki uzyskane za pomocą czujników korozymetrycznych uzupełniły podstawową diagnostykę, potwierdzając zasadność ich stosowania w ocenie skuteczności działania systemu ochrony katodowej.
Inclusive Storytelling: Community Reaction to Immigrant Youth Experiences in Atlanta
Authors: McDaniel Paul N. , Xiomara Rodriguez Darlene , Smith-Sitton Lara
Published: September 2021

From 2016 to 2018, an interdisciplinary community-engaged project incorporating community-based participatory research methodology, explored how the role of storytelling is integral for the transference of knowledge, history, and sense of purpose. The outcomes help us understand how the views of receiving communities change over time with respect to migrants through their own stories, thus impacting the work of immigrant-serving organizations, such as Georgia-based Welcoming America, a nonprofit committed to implementing a variety of initiatives to cultivate welcoming cities and welcoming regions. Our project gauges the impact of the 2018 publication, Green Card Youth Voices: Immigration Stories from an Atlanta High School.
Puppetry as a pedagogy of play in the Intermediate Phase mathematics classroom: A case study
Authors: Potgieter Erika , Van der Walt Marthie
Published: September 2021

Research on puppets in Intermediate Phase mathematics is in its infancy. According to Vygotsky, play affords a playful element that can optimise learning opportunities. However, many mathematics teachers are unfamiliar with the integration of pedagogy of play (PoP) (in this case, puppetry). The aim of this paper is to report on one participant’s (an Intermediate Phase mathematics teacher [N=1]) lived experiences of teaching with puppets after a two-day intervention. A case study approach was followed and the participant constantly reflected on his experiences. Data were collected through (i) a semi-structured open-ended interview, (ii) reflective prompts and (iii) a reflective journal with prompts. The data revealed the participant’s experiences of puppetry, how his metacognitive awareness developed and how he transferred new knowledge to his Intermediate Phase mathematics classroom. The data were analysed using content analysis. The results show that, although learners often deem mathematics “mundane” and “unexciting”, puppetry allowed the participant’s learners (according to his reflections) to experience this subject as enjoyable and creative, encouraging participation and liveliness, as the puppet was considered a peer in teaching-learning. The Intermediate Phase mathematics classroom became a space where content became meaningful, accessible and understandable to all learners.
The use of the process approach in South African English First Additional Language classrooms: A discourse analysis
Authors: Ngubane Nomalungelo
Published: September 2021

The Curriculum and Assessment Policy Statement suggests that enhanced cognitive and metacognitive writing skills are achieved when the process approach is used to teach writing (DoE, 2012). This paper presents findings on the process approach instruction used in selected South African English first additional language writing classrooms. It examines how teachers used the process approach to teach writing in selected further education and training (FET) phase writing classrooms in the Pinetown district in KwaZulu-Natal South Africa. Underpinned by socio-cultural learning theory, the study observed 15 writing lessons using a video camera. Classroom discourse analysis was used to analyse data. The findings reveal teachers’ knowledge of the process approach curriculum they are expected to implement. Time constraints in the FET phase writing curriculum hinder teachers’ in-depth facilitation of the stages of the process approach to writing. Traditional teaching strategies were prevalent in the process approach writing classrooms. I argue for a socio-cultural scaffolding model of writing that embraces activity-based writing strategies when dealing with writing development in the FET phase since this moves beyond formal accuracy and discrete aspects of language and situates writing within meaningful contexts and authentic purposes and, thus, prepares learners for post-school writing practices.
The Use of Model Intercomparison Projects in Engaging Undergraduates in Climate Change Research
Authors:   Fairfield University, Nazarian Robert
Published: September 2021

To improve model performance and study climate change impacts across physical, biological, and social systems, model intercomparison projects (MIPs) are regularly conducted. MIPs represent a crucial tool for undergraduate researchers to meaningfully contribute to climate change research.
Manajemen Risiko di Era Covid-19 Terhadap Ekonomi di Indonesia
Authors: Halida Uly Mabruroh
Published: September 2021

Masa pandemic covid-19 mampu mengubah hampir semua pola aktivitas masyarakat di dunia. Segala sesuatu yang mengundang kerumunan atau keterlibatan masyarakat banyak harus di hindari. Sehingga hal tersebut akan menimbulkan banyak dampak risiko dalam segala sektor kehidupan termasuk sektor ekonomi yang ada di dalamnya. Risiko merupakan suatu akibat yang tidak baik dan mampu menghambat suatu tujuan tertentu. Maka adanya manajemen risiko yang baik sangat dibutuhkan dalam situasi seperti ini agar mampu menanggulangi segala risiko yang timbul akibat covid-19. Penelitian ini bertujuan untuk mengetahui Risk Management di era Covid-19 dalam bidang ekonomi. Jenis penelitian ini merupakan jenis penelitian kepustakaan analisis data, reduksi data, display data. Adapun kesimpulan hasil penelitian ini menunjukkan bahwa Risk Management di era Covid-19 dalam bidang ekonomi saat ini dengan berbagai dampak yang terjadi terhadap perekonomian karena pandemic Covid-19 yaitu kesulitan dalam mencari lapangan pekerjaan, kesulitan untuk memenuhi kebutuhan sehari-hari, bahkan tidak mempunyai penghasilan dalam memenuhi kebutuhan hidup dan masih banyak lagi risiko yang terjadi dari sektor ekonomi lainnya. Adapun yang dilakukan pemerintah untuk meminimalisir risiko tersebut yaitu dengan cara mengeluarkan beberapa kebijakan moneter dan fiscal dengan harapan mampu memulihkan keadaan ekonomi Negara Indonesia.
DANÇAS POSSÍVEIS EM TEMPOS DE PANDEMIA
Authors: Baldi Neila Cristina , Schmidt Samara Weber
Published: September 2021

Este texto discute ações do projeto de extensão 5, 6, 7 e 8 – cursos e oficinas de Dança, do Curso de Dança-Licenciatura da Universidade Federal de Santa Maria (UFSM) durante o período de isolamento social provocado pela pandemia da Covid-19. Entre agosto e dezembro de 2020 foram desenvolvidas três ações on-line, duas em uma escola pública de Santa Maria: Crian(dan)ça, com crianças do ensino fundamental, e (Edu)Dançando na Escola, curso de formação continuada para professores(as). Paralelamente ocorreram as lives 5 e 6, que discutiram temas como Dança com Crianças e Educação Antirracista e Dança. O texto reflete sobre as dificuldades e desafios do ensino remoto e os benefícios da formação em Dança para profissionais da educação básica.
Safety in the use of car gas fuel installations
Authors: Chojnowski Janusz
Published: September 2021

The safe use of gas fuel installations in vehicles is guaranteed by legal and technical aspects. These topics are included in this study. The regulations ensuring safety in the operation of the mentioned fuel systems serve as a solution for potentially hazardous situations. The components of propane-butane and CNG fueling systems are designed, manufactured and tested to maximize their safety of use. The regulations [6, 7, 8] define the guidelines for the arrangement and assembly method of the system components, and additionally, the assembly service itself may be performed only by an authorized workshop with granted permissions. Installations using gaseous fuels are safer than conventional fuels in the event of a collision or fire, as long as the user of the installation does not gross negligence in operation and maintenance. The article also discusses the context of the restriction in access to the car infrastructure for cars powered by gaseous fuels.
Oscar Niemeyer e o mercado imobiliário de São Paulo na década de 1950: o escritório satélite sob direção do arquiteto Carlos Lemos e os edifícios encomendados pelo Banco Nacional Imobiliário
Authors:   Universidade Estadual de Campinas, Leal Daniela Viana
Published: September 2021

Esse trabalho propõe o estudo crítico de uma fase pouco discutida da trajetória do arquiteto Oscar Niemeyer tanto em textos nacionais quanto estrangeiros. Trata-se do período, na década de 1950, em que o carioca, realizou obras para o mercado imobiliário, em franca expansão, na cidade de São Paulo.
A recepção de motivos iconográficos gregos na Etrúria
Authors:   Universidade de São Paulo, Marotta Marcelo Hilsdorf
Published: September 2021

Os estudiosos do mundo etrusco tem sido praticamente unânimes, desde há muito, em reconhecer a importância da influência sobre este, isto é, sobre o mundo etrusco, do mundo e do universo da cultura grega.
A paleta formal construtiva de Flávio de Carvalho: arquitetura elaborada como um objeto artístico
Authors:   Universidade Federal de Minas Gerais, Lino Sulamita Fonseca
Published: September 2021

Flávio de Carvalho é conhecido por sua atuação profissional diversificada. Quando retornou ao Brasil, em 1923, formado em engenharia e artes plásticas na Inglaterra, passou a atuar em várias áreas, como arquitetura, artes plásticas, cenografia, desenho de figurinos, sendo esses apenas alguns exemplos.
A responsabilidade social dos bibliotecários em bibliotecas públicas
Authors: Ferreira Fernanda Bernardo , Siebra Sandra de Albuquerque
Published: September 2021

Introdução: A responsabilidade social consiste na atuação e no compromisso do profissional em proporcionar serviços e realizar ações voltados às necessidades de seus usuários e à produção de resultados que beneficiem a toda comunidade alvo. Objetivo: O objetivo geral deste artigo é analisar as dimensões e ações relacionadas à responsabilidade social desenvolvidas por bibliotecários em bibliotecas públicas. Metodologia: Caracteriza-se como uma pesquisa descritiva, quali quantitativa, bibliográfica e documental. Também foram coletados dados em três bibliotecas públicas na cidade do Recife, usando um questionário enviado aos bibliotecários destas bibliotecas através de e–mail. Adicionalmente foram mapeadas atividades e serviços ofertados remotamente, por meio do uso das redes sociais das bibliotecas, durante o período da pandemia do Covid-19, que provocou a suspensão das atividades, a partir de março/2020. Aos dados coletados foi aplicada a análise de conteúdo. Resultado: Como resultado foi realizado o mapeamento de dimensões e ações da função social das bibliotecas relacionadas à responsabilidade social, com base no referencial teórico, em análise documental e na análise dos questionários aplicados às bibliotecas estudadas. Conclusão: Verifica-se que a maioria das práticas de responsabilidade social mapeadas já fazem parte do fazer bibliotecário e que as dimensões ética, política, educacional e cultural contempladas nas atividades biblioteconômicas são abrangidas naquelas dimensões e ações. Logo, é notória a responsabilidade social do bibliotecário e, também da biblioteca pública enquanto espaço propício à promoção da leitura e da cidadania, ao incentivo da cultura, e à inclusão social e digital.
Strategies in Developing Creative Economic Activities Based on Local Wisdom
Authors: Putri Meldha Amanda , Abbas Ersis Warmansyah , Jumriani Jumriani
Published: September 2021

Ekonomi kreatif berbasis kearifan lokal lebih mengutamakan budaya sebagai ide kreatif dari pemikiran sendiri yang kemudian dapat berpengaruh positif dalam sebuah kehidupan bermasyarakat. Mengembangkan ekonomi kreatif berbasis kearifan lokal adalah cara untuk menstimulus perkembangan ekonomi kreatif untuk bisa mandiri dan bisa mengembangkan usaha terutama di daerah. Tujuan penulisan artikel ini yaitu untuk mendeskripsikan bagaimana upaya meningkatkan ekonomi kreatif berbasis kearifan lokal. Metode yang digunakan adalah studi literatur yaitu mengumpulkan buku, jurnal dan pustaka lainnya yang relevan. Pencarian data dilakukan dengan pencarian di google scholar dan ebook. Hasil penulisan artikel ini menjelaskan bahwa upaya yang dilakukan untuk mengembangkan produk ekonomi kreatif berbasis kearifan lokal yaitu dengan penetrasi pasar, pengembangan pasar dan pengembangan produk. Sedangkan upaya yang dilakukan dari pemerintah yaitu menyiapkan insentif pada pelaku usaha, mengadakan pelatihan ekonomi kreatif, dan peningkatan penggunaan teknologi.
Exploitation of Children as Buskers in Banjarmasin
Authors: Putra Muhammad Adhitya Hidayat , Handy Muhammad Rezky Noor , Rusmaniah Rusmaniah , Mardiani Fitri , Subiyakto Bambang
Published: September 2021

Fenomena anak-anak menjadi pengamen di kota-kota besar di Indonesia, seperti halmya fenomena di Kota Banjarmasin. Dalam penelitian ini bertujuan untuk mengkaji factor-faktor sosial dan peran orang tua terhadap kegiatan anak-anak pengamen yang ada di kota Banjarmasin. Metode yang digunakan yaitu pendekatan kualitatif, pengumpulan data dilakukan dengan observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa anak-anak pengamen di Kota Banjarmasin berasal dari keluarga yang kurang mampu dan memiliki pendidikan yang sangat rendah, serta ekonomi yang dibawah, bentuk eksploitasi keluarga terhadap anak-anak tersebut adalah menjadikan mereka sebagai pengamen yang biasanya berada di wilayah lampu merah. Pemerintah juga telah melakukan berbagai macam upaya untuk mengurangi jumlah pengamen anak-anak di jalan kota Banjarmasin, tetapi hasilnya belum maksimal hingga saat ini terutama dalam masa pandemic covid-19 semakin menjamur.
Дослідження якості поверхні друкувальних елементів форм інтагліодруку, виготовлених прямим лазерним гравіюванням
Authors: Киричок Тетяна Юріївна , Баглай Володимир Анатолійович , Талімонова Надія Леонідівна , Клименко Тетяна Євгенівна , Безпалий Андрій Анатолійович
Published: September 2021

У статті представлено результати дослідження параметрів профілю гравійованих штрихів, отриманих методом прямого лазерного гравіювання. Дослідження методами оптичної металографії шліфів гравійованих штрихів, що відрізнялися запроектованим профілем показало, що всі гравійовані штрихи зразка мають відхилення від заданого геометричного профілю (нахил стінки штриха 90⁰ зменшується до 60⁰–75⁰), є несиметричними, захисне PVD (Plate Vapour Deposition) покриття має недостатню адгезію до основного матеріалу форми.
Дослідження шорсткості поверхні досліджуваних друкарських форм на ділянках пробільних та друкувальних елементів за допомогою механічного профілографування показало, що шорсткість пробільних елементів форм суттєво нижча, ніж шорсткість дна друкувальних елементів, що повністю кореспондується з даними досліджень мікрошліфів. Також це підтверджено мікроскопічними дослідженнями дна друкувальних елементів: нерівності мають регулярний характер, що спричинено особливостями лазерного оброблення поверхні.
Аналіз отриманих даних дає підстави стверджувати, що особливості обробки матеріалу форми лазером під час DLE, впливає на шорсткість оброблюваних поверхонь та утворює напливи, що може мати негативний вплив на адгезію захисного PVD покриття, що суттєво знизить тиражостійкість друкарських форм. Зважаючи на цей факт, доцільним є удосконалення технологічних режимів лазерного гравіювання поверхні латуні.
Essential Oil of Lippia origanoides H.B.K.: A Promising Compound Acetylcholinesterase Inhibitors for the Treatment of Alzheimer’s Disease
Authors: Ximenes Rodrigues Aldenora Maria , Gomes dos Santos Brenda Nayranne , Machado Ranyelison Silva , de Sousa Carmo Rubens Renato , de Oliveira Matheus Pedrosa , Lopes Citó Antônia Maria das Graças , de Medeiros Carvalho Maria das Graças Freire , dos Santos Leite Paulo Tércio
Published: September 2021

Alzheimer's disease is characterized by a progressive decline of cognitive functions. The class of drugs used for the treatment are acetylcholinesterase inhibitors. Essential oils have contributed to folk medicine and discovery of new drugs for a long time. The purpose of the study was to investigate the in vitro and in silico the anti-acetylcholinesterase activity, as well as acute toxicity of the essential oil of Lippia origanoides. EOLO was obtained by hydrostelting and analyzed by gas chromatography-mass spectrometry. The inhibition assay of acetylcholinesterase enzyme activity was evaluated in vitro, as well as in silico by docking. The effects of EOLO on hematological, biochemical and behavioral parameters were analyzed in mices. We expose that EOLO shows good anti-acetylcholinesterase activity and low toxicity, possibly resulting from the action of the majority compounds thymol, carvacrol and p-cymene. The anti-acetylcholinesterase potential in vitro demonstrating a 70% inhibition. The docking results elucidated the participation of the major phenolics in AChE inhibition by interacting with the catalytic cavity of AchE. The acute oral toxicity test classified as low toxicity. These results contribute to expand the knowledge about essential oil of Lippia origanoides. Therefore, appears to be promising for herbal medicine production with anti-acetylcholinesterase and antioxidant activity.
Effects of Intercropping on Soil Fractal Dimension and Physicochemical Properties in the Karst Areas
Authors: Xu Qin qin , Xiong Kang ning , Chi Yong kuan
Published: September 2021

Suitable soil structure and nutrient security are important for plant growth and development, characteristics of soil fractal dimension and distribution of physical and chemical properties and their interactions play an important role in studying the stability of soil structure and water and fertilizer cycles. As a sustainable management model, intercropping has positive benefits for erosion control, spatial optimization of resources, as well as improving system productivity. The effects of four intercropping methods on soil fractal dimension and physicochemical properties were investigated by intercropping Salvia miltiorrhiza with forage and S. miltiorrhiza with forest under typical karst rock desertification habitats in Guizhou. The results showed that soil nutrient content of intercropping was significantly higher than that of monoculture, the organic carbon content of soil grown under forest is higher than other treatments, and there was a non-significant change in soil water content of intercropping compared with monoculture. The soil fine-grained matter of intercropping was significantly higher than that of monoculture, while the soil fractal dimension showed a tendency to become larger with the increase of fine-grained matter. The intercropping planting, due to its component types and spatial and temporal configurations, leads to differences in soil water and fertilizer interactions, which can be combined with other ecological restoration measures to optimize the composite model and jointly promote the restoration and development of ecologically fragile areas.
Water-Resistant Surface Modification of Hydrophobic Polymers With Water-Soluble Surfactant Additives
Authors: Gibson Colin , Litwinowicz Matthew , Tellam James , Wellbourn Rebecca , Skoda Maximilian W.A. , Claussen Jan , Thompson Richard L.
Published: September 2021

Water-soluble nonionic surfactant, pentaethylene glycol monododecyl ether, C12E5, spontaneously blooms to the surface of spin-cast hydrophobic polyiso-prenes, generating hydrophilic surfaces. This system represents a simple model for hydrophilic chemical modification of rubbery polymers yet demonstrates surprisingly rich, complex and unexpected behaviour. The ver-tical depth profiles were quantified using neutron reflectometry (NR) and deuterated surfactant, and the surface properties were characterized using con-tact angle analysis and atomic force microscopy (AFM). Despite the low surface tension of the toluene solvent used in film preparation and the low surface en-ergy of the PI matrix, NR depth profiles revealed clear evidence of surfactant segregation. This surface layer was typically thicker than a monolayer, but incomplete, yet was remarkably stable with respect to dissolution, even when exposed to hundreds of thousands of times the volume of water required to dissolve all the surfactant on the surface. Despite the apparent resistance to removal from the surface, water exposure does alter the subsequent wettabil-ity of the surface, with a hydrophilic-to-hydrophobic transition occurring after rinsing. Complementary AFM images of these C12E5 / cis-PI films showed unexpected strand-like features on the surface of the film, which we attribute to a non-uniform lateral distribution of some of the surfactant. This surface structure becomes more evident after rinsing, and it appears that there are two distinct populations of surfactant on the PI film surface. We conclude that some of the bloomed surfactant exists as layers, which are relatively inert with respect to rinsing or surface modification, and some is laterally inhomogene-ous. This latter population is primarily responsible for surface wetting be-havior, but is not detected by specular NR.
Network Pharmacology of Red Ginseng (Part I): Effects of Ginsenoside Rg5 at Physiological and Sub-Physiological Concentrations
Authors: Panossian Alexander , Abdelfatah Sara , Efferth Thomas
Published: September 2021

Numerous in vitro studies on isolated cells have been conducted to uncover the molecular mechanisms of action of Panax ginseng Meyer root extracts and purified ginsenosides. However, the concentrations of ginsenosides and the extracts used in these studies were much higher than detected in pharmacokinetic studies in humans and animals orally administered with ginseng preparations at therapeutic doses. Our study aimed to assess: (a) the effects of ginsenoside Rg5, the major "rare" ginsenoside of Red Ginseng, on gene expression in the murine neuronal cell line HT22 in a wide range of concentrations, from 10-4 to 10-18 M, and (b) the effects of differentially expressed genes on cellular and physiological functions in organismal disorders and diseases. Gene expression profiling was performed by transcriptome-wide mRNA microarray analyses in HT22 cells after treatment with ginsenoside Rg5. Ginsenoside Rg5 exhibits soft-acting effects on gene expression of neuronal cells in a wide range of physiological concentrations and strong reversal impact at high (toxic) concentration: significant up- or downregulation of expression of about 300 genes at concentrations from 10-6 M to 10-18 M, and dramatically increased both the number of differentially expressed target genes (up to 1670) and the extent of their expression (fold changes compared to unexposed cells) at a toxic concentration of 10-4 M. Network pharmacology analyses of genes expression profiles using Ingenuity pathway analysis (IPA) software showed that at low physiological concentrations, ginsenoside Rg5 has the potential to activate the biosynthesis of cholesterol and to exhibit predictable effects in senescence, neuroinflammation, apoptosis, and immune response, suggesting soft-acting, beneficial effects on organismal death, movement disorders, and cancer.
Roles of Arbuscular Mycorrhizal Fungi on Soil Fertility and Its Importance in Phytoremediation of Polluted Soil
Authors: Fall Abdoulaye Fofana , Nakabonge Grace , Ssekandi Joseph , Founoune-Mboup Hassna , Apori Samuel Obeng , Ndiaye Abibatou , Badji Arfang , Ngom Khady
Published: September 2021

A single paragraph Arbuscular mycorrhizal fungi (AMF) establish symbiotic relationships with many crops. These soil microbiotas improve the soil fertility through the soil physical, chemical and biological properties. extending the root absorbing area. In return, the symbiont receives plant carbohydrates for the completion of its life cycle. AMF also helps plants to cope with biotic and abiotic stresses such as extreme temperature, heavy metal, diseases, and pathogens. For soil physical properties, the mechanisms used by AMF are the production of a glycoprotein, glomalin, which creates a high quality of soil macro-aggregations. These macro-aggregations control soil erosion, nutrients and organic matter losses. For soil chemical properties, AMF produce acids and an enzyme called phosphatase. This enzyme hydrolyzes the inorganic phosphorus and the rock phosphate (RP) hence making P available in the soil for plant uptake. AMF also are involved in soil nitrogen, carbon and trace element cycling. Regarding the biological component of the soil, AMF influence the composition, diversity and activity of microbial communities in the hydrosphere. They also work in synergy with others soil microorganisms to improve soil fertility, plant growth and resistance against some diseases. In this review, we present the contribution of AMF on soil fertility and importance in polluted soils.
Positive Mathematical Programming to Model Regional or Basin-Wide Implications of Producer Adoption of Practices Emerging from Plot-Based Research
Authors: Quintana-Ashwell Nicolas , Kaur Gurpreet , Singh Gurbir , Gholson Drew M. , Delhom Chris , Krutz L. Jason , Hegde Shraddha
Published: September 2021

A method for calibrating models of agricultural production and resource use presented by Howitt [1] for policy analysis is proposed to leverage multidisciplinary agricultural research at the National Center for Alluvial Aquifer Research (NCAAR). An illustrative example for Sunflower County, MS is presented to show how plot-level research can be extended to draw systemic region or basin wide implications. A hypothetical improvement in yields for dryland soybean varieties is incorporated to the model and shown to have a positive impact on aquifer outcomes and producer profits. The example illustrates that a change in one practice-crop combination can have system-wide impacts as evidenced by the change in acreages for all crops and practices.
A Lagrangian Tool for Simulating the Transport of Chemical Pollutants in the Arabian/Persian Gulf
Authors: Periáñez Raúl
Published: September 2021

A rapid-response Lagrangian model for simulating the transport of a chemical pollutant in the Arabian/Persian Guls is described. The model is well suited to provide a fast response after an emergency due to an accident or a deliberate spill. Baroclinic circulation was obtained from HYCOM ocean model and tides were calculated using a barotropic model. The interactions of pollutants with sediments (uptake/release processes) were described using a dynamic approach based on kinetic transfer coefficients and a stochastic numerical method. Some examples of model applications are shown.
Estimation of the Lifespan Distribution of Gold Nanoparticles Stabilized with Lipoic Acid by Accelerated Degradation Tests and Wiener Process
Authors: Sánchez-Santamaría Betania , Mederos Boris , Cornejo-Monroy Delfino , Molina-Arredondo Rey David , Castaño Víctor
Published: September 2021

Accelerated degradation tests (ADT) are widely used in the manufacturing industry to obtain information on the reliability of components and materials, through degrading the lifespan of the product by applying an acceleration factor which causes damage to the material. The main objective is to obtain fast information which is modeled to estimate the characteristics of the material life under normal conditions of use and to save time and expenses. The purpose of this work is to estimate the lifespan distribution of gold nanoparticles stabilized with lipoic acid (GNPs@LA) through accelerated degradation tests applying sodium chloride (NaCl) as an acceleration factor. For this, the synthesis of GNPs@LA was carried out, a constant stress ADT (CSADT) was applied, and the non-linear Wiener process was proposed with random effects, error measures and different covariability for the adjustment of the degradation signals. The information obtained with the test and analysis allows us to obtain the life distribution in GNPs@LA, the results make possible to determine the guaranteed time for a possible commercialization and successful application based on the stability of the material. In addition, for the evaluation and selection of the model, the Akaike and Bootstraping criteria were used.
Toxocarosis in the South of Russia: epidemiological and environmental aspects
Authors:   Rostov Research Institute of Microbiology and Parasitology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Rostov-on-Don, Russian Federation, Khutoryanina I.V. , Tverdohlebova T.I. ,   Rostov Research Institute of Microbiology and Parasitology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Rostov-on-Don, Russian Federation,   Rostov State Medical University, Rostov-on-Don, Russian Federation
Published: September 2021

Toxocarosis is a widespread parasitic infection and a significant healthcare challenge. Humans can be infected through contacts with animals and soil contaminated by eggs of Toxocara сanis. Children aged 3–5 years are particularly vulnerable population because of their active contact with soil. Veterinary specialists, people working in dog shelters, zoos, groceries, and people who have gardens are also at risk of infection. Objective. To analyze the epidemiological situation of toxocarosis in the South of Russia. Materials and methods. The Laboratory of Sanitary and Parasitological Monitoring, Medical Parasitology, and Immunology of Rostov Research Institute of Microbiology and Parasitology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, has been continuously monitoring the situation with parasitoses in the Southern Federal District for many years. A total of 1,026 samples of soil were collected in 2012–2020. We performed serological and epidemiological examination for toxocarosis among residents of this Federal District. Results. We found that the number of seropositive individuals and soil contamination with the eggs of Toxocara spp. in the Southern Federal District were high and were not consistent with the official figures of toxocarosis incidence. This suggests that the true level of toxocarosis incidence is significantly higher than that officially reported for this territory. Conclusion. Our study confirmed that environment contamination with the eggs of Toxocara spp. is the main risk factor for toxocarosis in humans. Key words: toxocarosis, Toxocara spp., epidemiological situation, enzyme-linked immunosorbent assay, sanitary and parasitological examination, soil
Influence of Organizational Culture and Empowerment correlated to Work Engagement As an Intervening Variables towards to the Serivice Quality of General Bureau at the Ministry of State Secretariat
Authors: Haryono Koko
Published: September 2021

The aim of this research is to reveal the effect of organizational culture and empowerment correlated to work engagement as an intervening variable in relations to general affairs quality serviceability in term of directly nor indirectly, as well as considering the adjusted strategy to enhance serviceability quality. This research uses survey method in quantitative research. The sum of this research is depicted from staff members of General Affairs at The Indonesian Foreign Affairs of The Republic of Indonesia. It is denoted as N = 307 staffs using Slovin Theory obtained n = 76. The technique in analyzing data used SPSS and LISREL. In the result of the research revealed that (1) the culture of an organization has a direct impact towards the quality of a service, (2) empowerment gives a direct positive impact on service quality, (3) work bonding also gives a positive reaction on a quality of a service, (4) moreover, an organizational culture response a straight positive outcome on a network, (5) empowerment also give a straightforward outcome on work bondage, (6) culture of an organization also gives a direct impact on empowerment, (7 ) the culture of an organization through empowerment results a positive impact on service quality, (8) culture of an organization through a work bondage gives a positive effect on service quality at General Affairs at The Indonesian Foreign Affairs of The Republic of Indonesia. Based on a hypothetical analysis it was discovered that an organizational culture has a high encounter on a service quality of 0,323 or 32,3%. Whereas a variable indirect impact resulted organizational culture had no direct impact on service quality through empowerment with the value of 0,509 or 50,9%. This result will be used as a testimony for the institution in order to maintain as well as elevate and expand the dimension and it’s indicator I order to increase service quality of General Affair’s staffs. Thus, can be concluded that in order to generate an optimal service quality among staffs, an organization necessitates to manufacture and uplift organizational culture, empowerment and work bond among the staffs.
Surgical Excision of a Giant Schwannoma of the Hand
Authors: Moran Jay , Kahan Joseph B. , Schneble Christopher A. , Lindskog Dieter , Donohue Kenneth
Published: September 2021

Case:

We report a 78-year-old man who underwent excision of a 13-year-old benign schwannoma originating from the terminal motor branch of the ulnar nerve. The mass measured 13 cm in diameter on presentation and was successfully excised, preserving a functional hand. At 4-year follow-up, the patient was asymptomatic with intact motor and sensory function and no signs of recurrence. To the best of our knowledge, this is the largest schwannoma of the hand to be reported in the literature.

Conclusions:

Large schwannomas of the hand can successfully be excised with no postoperative complications.
Virtual Orthopaedic Examination of the Lower Extremity
Authors: Emara Ahmed K. , Zhai Kevin L. , Rothfusz Christopher A. , Minkara Anas A. , Genin Jason , Horton Scott , King Dominic , Schaffer Jonathan L. , Piuzzi Nicolas S.
Published: September 2021

» Telemedicine has become an emerging necessity in the practice of orthopaedic surgery following the paradigm shift that was brought on by the COVID-19 pandemic.

» Physical examination is an integral component of orthopaedic care and plays a crucial role in diagnosis.

» Based on our experience and expert opinion in the literature, we recommend the following infrastructure for a virtual orthopaedic physical examination: a computing device with a functioning camera and high-definition input/output audio, a 720p (high-definition) display, a processing speed of 3.4 GHz, an internet connection speed range from 1 to 25 Mbps, adequate lighting, a steady camera that is positioned 3 to 6 ft (0.9 to 1.8 m) from the patient, a quiet environment for the examination, and clothing that exposes the area to be examined.

» When performing a virtual examination of the lower extremity, inspection, range of motion, and gait analysis can be easily translated by verbally instructing the patient to position his or her body or perform the relevant motion. Self-palpation accompanied by visual observation can be used to assess points of tenderness. Strength testing can be performed against gravity or by using household objects with known weights. Many special tests (e.g., the Thessaly test with knee flexion at 20° for meniscal tears) can also be translated to a virtual setting by verbally guiding patients through relevant positioning and motions.

» Postoperative wound assessment can be performed in the virtual setting by instructing the patient to place a ruler next to the wound for measuring the dimensions and using white gauze for color control. The wound can be visually assessed when the patient’s camera or smartphone is positioned 6 to 18 in (15 to 46 cm) away and is held at a 45° angle to the incision.