bluuebunny/crossref_metadata_2025 huggingface dataset:
Escola nova e bolchevismo
Authors: Moraes José Damiro
Published: June 2019

Este artigo tem como objetivo estudar dois episódios que ocorreram no ano de 1937 e envolveram dois signatários do Manifesto de 1932: o educador Lourenço Filho e a conhecida escritora e educadora Cecília Meireles. A partir da análise de documentos da biblioteca do Conselho Nacional de Educação e do Arquivo do Supremo Tribunal Federal, trazemos algumas reflexões sobre o fechamento da Biblioteca Infantil do Pavilhão Mourisco dirigido por Cecília Meireles, acusado de conter livros comunistas e os impactos deste fechamento no interior do Conselho Nacional de Educação. Neste episódio, Lourenço Filho foi alvo de acusação pelo jornal O Povo de ser comunista justamente em um momento que diversas pessoas estavam presas e investigadas por suposta participação na “Intentona Comunista” de 1935. O estudo analisou fontes primárias e procurou confrontar com elementos que apontavam no horizonte cada vez mais próximo a imposição de um Estado de Exceção, que se configurou em novembro de 1937. Neste sentido, compreender esses episódios como cenas acessórias junto à ação principal da complexa realidade do período em que a Escola Nova se colocava como uma alternativa à educação do período ajuda a problematizar a complexa realidade dos anos 1930 e seus desfechos.
A Survey of Field Experiences With Formate Drilling Fluid
Authors: Gao Chang Hong
Published: June 2019

High temperatures and wellbore-integrity issues are often encountered when drilling onshore and offshore wells. Formate drilling fluid was initially developed in the 1990s to battle high temperature. Field applications of formate mud have increased since the 2000s. This paper presents worldwide implementations of formate drilling fluid, including field cases in Canada, the North Sea, Germany, the Middle East, and Russia. Experiences with formate mud in Chinese fields that were previously unknown because of the language barrier are also reported. Most field cases reported high rate of penetration (ROP), excellent wellbore stability, good thermal stability, and high production rates upon completion. Reclamation and reuse of formate have significantly improved the cost–effectiveness of formate mud. In the current drilling industry, formate fluid has become one of the best choices for battling high–temperature and wellbore–stability issues.
Evidence-Based Physical Therapy Practice in the State of Kuwait: A Survey of Attitudes, Beliefs, Knowledge, Skills, and Barriers (Preprint)
Authors: Alrowayeh Hesham N , Buabbas Ali J , Alshatti Talal A , AlSaleh Fatemah M , Abulhasan Jawad F
Published: June 2019

BACKGROUND

Evidence-based practice (EBP) is necessary to improve the practice of physical therapy. However, a lack of knowledge and skills among physical therapists and the presence of barriers may hinder the implementation of EBP in the State of Kuwait.

OBJECTIVE

The objectives of this study were to extensively (1) investigate attitudes toward EBP, (2) assess the current level of knowledge and skills necessary for EBP, and (3) identify the barriers to EBP among physical therapists in the State of Kuwait.

METHODS

The following methods were used: (1) a previously validated self-reported questionnaire and (2) a face-to-face semistructured interview. The questionnaire, which was distributed to 200 physical therapists, examined the attitudes and beliefs of physical therapists about EBP; the interest in and motivation to engage in EBP; educational background, knowledge, and skills related to accessing and interpreting information; the level of attention to and use of the literature; access to and availability of information to promote EBP; and the perceived barriers to using EBP. The interview explored the factors that promote or discourage EBP. Descriptive statistics and logistic regression analyses were used.

RESULTS

Of the 200 nonrandomly distributed questionnaires, 92% (184/200) were completed and returned. In general, the physical therapists had positive attitudes, beliefs, and interests in EBP. Their educational background, knowledge, and skills related to assessing and interpreting information were well-founded. The top 3 barriers included insufficient time (59.2%, 109/184), lack of information resources (49.4%, 91/184), and inapplicability of the research findings to the patient population (40.7%, 75/184).

CONCLUSIONS

EBP lacks support from superiors at work. Thus, identifying methods and strategies to support physical therapists in adopting EBP in the State of Kuwait is necessary.
The Service of Research Analytics to Optimize Digital Health Evidence Generation: Multilevel Case Study (Preprint)
Authors: Pham Quynh , Shaw James , Morita Plinio P , Seto Emily , Stinson Jennifer N , Cafazzo Joseph A
Published: June 2019

BACKGROUND

The widespread adoption of digital health interventions for chronic disease self-management has catalyzed a paradigm shift in the selection of methodologies used to evidence them. Recently, the application of digital health research analytics has emerged as an efficient approach to evaluate these data-rich interventions. However, there is a growing mismatch between the promising evidence base emerging from analytics mediated trials and the complexity of introducing these novel research methods into evaluative practice.

OBJECTIVE

This study aimed to generate transferable insights into the process of implementing research analytics to evaluate digital health interventions. We sought to answer the following two research questions: (1) how should the service of research analytics be designed to optimize digital health evidence generation? and (2) what are the challenges and opportunities to scale, spread, and sustain this service in evaluative practice?

METHODS

We conducted a qualitative multilevel embedded single case study of implementing research analytics in evaluative practice that comprised a review of the policy and regulatory climate in Ontario (macro level), a field study of introducing a digital health analytics platform into evaluative practice (meso level), and interviews with digital health innovators on their perceptions of analytics and evaluation (microlevel).

RESULTS

The practice of research analytics is an efficient and effective means of supporting digital health evidence generation. The introduction of a research analytics platform to evaluate effective engagement with digital health interventions into a busy research lab was ultimately accepted by research staff, became routinized in their evaluative practice, and optimized their existing mechanisms of log data analysis and interpretation. The capacity for research analytics to optimize digital health evaluations is highest when there is (1) a collaborative working relationship between research client and analytics service provider, (2) a data-driven research agenda, (3) a robust data infrastructure with clear documentation of analytic tags, (4) in-house software development expertise, and (5) a collective tolerance for methodological change.

CONCLUSIONS

Scientific methods and practices that can facilitate the agile trials needed to iterate and improve digital health interventions warrant continued implementation. The service of research analytics may help to accelerate the pace of digital health evidence generation and build a data-rich research infrastructure that enables continuous learning and evaluation.
An App Predicting Peritoneal Dialysis Appropriate Dwell Volume for Patients in Daily Practice (Preprint)
Authors: Wang Hsien-Yi , Kan Wei-Chih , Chien Chih-Chiang , Chien Tsair-Wei
Published: June 2019

BACKGROUND

Few studies mention how to objectively adjust peritoneal dialysis (PD) dwell volume (DV) for adult continuous ambulatory peritoneal dialysis patients. It requires a great deal of physicians’ precious time to determine the appropriate DV during daily practice. An app with evidence is required to solve this problem independently and efficiently.

OBJECTIVE

This study aims to determine a method for fluid control that can reduce fluid overload-related complications. We proposed a reference equation composed of parameters from the peritoneal equilibration test (PET) for adjusting daily dialysate DV to obtain more ultrafiltration volume.

METHODS

Ninety PD patients being treated at one medical center were enrolled, with laboratory data collected during half-yearly PET evaluations. The instilled dialysate was composed of 2.57% glucose PD fluid, either 1500 ml or 2000 ml for two groups in DV. We measured intraperitoneal pressure (IPP) before dialysate instilled (P0) and drained in the supine position after four hours (P4), effluent volume (ml), body mass index (BMI), waist circumference, and other parameters, including social demographics, to predict the appropriate DV. Exploratory factor analysis (EFA) was performed to extract independent domains. Statistical multivariate techniques of discrimination analysis and logistic regression (LR) to verify the most feasible and optimal formula were applied to determine infill volumes for patients. A final equation for fine-tuning daily DV was proposed with an app to be used for physicians and patients in clinical settings.

RESULTS

Two domains were observed by using EFA: (1) P0, and P4, and effluent volume and (2) BMI and wais circumference. We determined a formula for calculating daily dialysate DV, derived from L to obtain an accurate prediction rate of 94.44% higher than the previous study at 80.68%: Z = 4.32974 + 3.85477 * F1 + 3.83008 * F2. An app was created to easily adjust the DV in the daily procedure.

CONCLUSIONS

The novel formula, combined with an app using objective, real-time parameters for predicting appropriate DVs, was proposed for PD patients to optimize maximal ultrafiltration volumes and reduce subjective abdominal discomfort. DV is easy to calculate using the app, which makes it possible for physicians or patients to make frequent adjustments.

CLINICALTRIAL

Not available
Complications in type III open tibial shaft fractures treated with open reduction and internal fixation
Authors: Chitnis Abhishek S , Vanderkarr Mollie , Sparks Charisse , McGlohorn Jonathan , Holy Chantal E
Published: June 2019

Aim:
To estimate rates of fracture-related infection (FRI) and nonunion and assess the healthcare burden associated with FRI among patients with open reduction and internal fixation (ORIF) for Type III open tibial shaft fractures (TSFs).
Methods:
Patients with type III TSF requiring ORIF were identified using MarketScan
®
Database. Healthcare utilization and total costs were compared using generalized linear models.
Results:
The rates of FRI and nonunion were 35.99 and 36.94%, respectively, at 365 days. Patients with FRI had a significantly higher rate of readmission, emergency room visit and total healthcare costs compared with patients without FRI.
Conclusion:
Patients with an ORIF procedure for Type III TSF have a high risk of FRI and nonunion and; FRI significantly increased the healthcare burden.
Entre moradas, ruas e estórias: Ensaio etnográfico sobre ruptura, memória do trabalho e itinerários urbanos em uma vila operária na cidade de Porto Alegre
Authors: Lopo Rafael Martins
Published: June 2019

Este artigo relata o início de uma pesquisa realizada em um bairro operário na cidade de Porto Alegre. Tendo como universo principal uma Vila operária moldada nas bases das cidades-jardins inglesas, procuro refletir como a relação dos moradores com o bairro, suas memórias e sua particularidade é agenciada em suas narrativas. Em um primeiro momento, discuto as noções de bairro e de unidade através da história e projeto do bairro, para posteriormente me inserir neste espaço através de relatos retirados dos diários de campo e narrativas dos moradores, para compreender melhor como as práticas cotidianas destes sujeitos falam sobre as feições do local e sobre uma memória do trabalho na cidade de Porto Alegre. Palavras chave: Memória. Trabalho. Narrativa.   Between addresses, streets and stories: a ethnographic essay about rupture, memory labor and urban itineraries in a workers' village in the city of Porto Alegre, RS, Brasil   Abstract This article reports de beggining of a research made in a working-class neighborhood in the city of Porto Alegre. With the main universe a workers' village shaped in the bases of the english garden-cities, I try to reflect how the relationship of dwellers, their memories and their peculiarities are agencied in their narratives. In a first moment, I discuss the notions of neighborhood and unit trough the history and the project of the village to, ulterior, insert myself in this space by reports of filed diaries and narratives from the residents, to better understand how the daily practices from this subject talk about the features of the site and about a working memory  in the city of Porto Alegre. Keywords: Memory. Work. Narrative.
Measurement of user satisfaction in vertical pedestrian movements
Authors: Arslan Mesut
Published: June 2019

This research study examines the human relationship with the staircase, the
vertical circulation tool, in terms of user satisfaction. In the literature,
the lack of papers dealing with user satisfaction in detail within the scope
of dimensional competence necessitates this study. The satisfaction values
of the stair users and the variables affecting these values, and at the same
time, the realisation of the satisfaction analysis of the existing national
stairway standards constitute the main objective of the study. For this
purpose, 400 user satisfaction surveys were conducted in two different
application areas and analysed by Statistical Package for the Social
Sciences software. According to the findings of the research, the stairs
chosen in the application areas are designed in accordance with national
stairway standards. Users expressed their dissatisfaction with
normal-to-weak-weighted negative feedback on the variables of visual
admiration, dimensional competence, safety and fatigue. Finally, the
existence of the relationship between the variables affecting the user
satisfaction is examined; recommendations based on user satisfaction for
staircases design are offered.
A method for case selection in strategic urban planning
Authors: Sretovic-Brkovic Visnja
Published: June 2019

Strategic planning application is frequent in urban practices. In order to
understand this type of planning in a better way, urban researches use and
take over good examples of practices from other countries. Selecting examples
is most often made without considering their context and the specifics of the
urban planning process. In practice, it results in the strategies which are
not implemented and the plans which are not realized. The aim of the
conducted research is to simplify the urban planners and researchers' choice
of compatible good practice cases from different types of environment. This
is achieved by creation of an evaluation model, whose role is to help select
examples from different environments compatible with the environment where
the research is conducted.
Crowdsourcing in participatory planning: Online platforms as participative ecosystems
Authors: Segedinac Goran , Reba Darko
Published: June 2019

Insufficient public presence within the traditional participatory activities
in urban planning is largely caused by their incompatibility with the
communication preferences of the public they are addressing. Accordingly,
this research is aimed at identifying alternative approaches which enable
the creation of new communication channels and improve the level and quality
of participation. Starting from the hypothesis that technological
development has changed the way we communicate, the goal of this research is
to provide the deeper understanding of the current potentials and problems
of internet participation in urban planning and also to point out on the
future development strategies, which could address the problems we are
facing today. By analyzing case studies in which Internet communication is
used for this purpose, as well as publicly available data about user
activities within the popular web platforms, we investigate the main
advantages and disadvantages of the described practice, as well as the
opportunities of the application of new communication approaches and
technological trends, such as crowdsourcing activities and blockchain
technology.
Differential Effect of Glucose on ER-Mitochondria Ca2+ Exchange Participates in Insulin Secretion and Glucotoxicity-Mediated Dysfunction of β-Cells
Authors: Dingreville Florian , Panthu Baptiste , Thivolet Charles , Ducreux Sylvie , Gouriou Yves , Pesenti Sandra , Chauvin Marie-Agnès , Chikh Karim , Errazuriz-Cerda Elisabeth , Van Coppenolle Fabien , Rieusset Jennifer , Madec Anne-Marie
Published: June 2019

Glucotoxicity-induced β-cell dysfunction in type 2 diabetes is associated with alterations of mitochondria and the endoplasmic reticulum (ER). Both organelles interact at contact sites, defined as mitochondria-associated membranes (MAMs), which were recently implicated in the regulation of glucose homeostasis. The role of MAMs in β-cells is still largely unknown, and their implication in glucotoxicity-associated β-cell dysfunction remains to be defined. Here, we report that acute glucose treatment stimulated ER-mitochondria interactions and calcium (Ca2+) exchange in INS-1E cells, whereas disruption of MAMs altered glucose-stimulated insulin secretion (GSIS). Conversely, chronic incubations with high glucose of either INS-1E cells or human pancreatic islets altered GSIS and concomitantly reduced ER Ca2+ store, increased basal mitochondrial Ca2+, and reduced ATP-stimulated ER-mitochondria Ca2+ exchanges, despite an increase of organelle interactions. Furthermore, glucotoxicity-induced perturbations of Ca2+ signaling are associated with ER stress, altered mitochondrial respiration, and mitochondria fragmentation, and these organelle stresses may participate in increased organelle tethering as a protective mechanism. Last, sustained induction of ER-mitochondria interactions using a linker reduced organelle Ca2+ exchange, induced mitochondrial fission, and altered GSIS. Therefore, dynamic organelle coupling participates in GSIS in β-cells, and over time, disruption of organelle Ca2+ exchange might be a novel mechanism contributing to glucotoxicity-induced β-cell dysfunction.
ERA DISRUPSI DAN IMPLIKASINYA BAGI REPOSISI MAKNA DAN PRAKTEK PENDIDIKAN (KAJI PETIK DALAM PERSPEKTIF ELEKTIK SOSIAL ANALISIS)
Authors: Lasmawan I Wayan
Published: June 2019

Tujuan dari tulisan ini adalah membedah secara grounded simpulisasi era disrupsi dan implikasinya terhadap makna dan praktek pendidikan dalam perspektif elective social analysis untuk “menciptakan’ dan “mendorong” lahirnya stigma baru tentang pendidikan yang dibutuhkan di era disrupsi. Kaji petik ini lebih merupakan autokritik dan kesadaran diri atas betapa penting dan strategisnya pendidikan dalam “memainkan peran” dan “mengatur lakon” kehidupan masyarakat dunia agar bersesuaian dengan tagihan jaman.

 

Berdasarkan kaji petik yang dilakukan, diperoleh simpulan bahwa: (1) disrupsi merupakan istilah yang dipopulerkan oleh Clayton Christensen sebagai kelanjutan dari tradisi berpikir “for you to win, you’ve got to make somebody lose”. Hal ini menstimuli lahirnya teori disruptive innovationyang menjelaskan fenomena dimana sebuah inovasi mengubah pasar atau sektor yang ada dengan memperkenalkan kesederhanaan, kenyamanan, aksesibilitas, dan keterjangkauan (simplicity, convenience, accessibility, and affordability) di mana komplikasi (keruwetan)  dan biaya tinggi di posisi status quo, (2) era disrupsi terjadi karena perkembangan teknologi komunikasi, munculnya generasi millenials, kebutuhan pola pikir eksponensial, corporate mindset, model bisnis disruptif, dan era internet of things, (3) aspek-aspek dari disrupsi tersebut secara umum meliputi: aspek sosio-demografis atau mobilitas social, aspek struktur organisasi sosial atau lembaga-lembaga kemasyarakatan, sosio-politik, dan aspek psikokultural, (4) dampak disrupsi secara global terutama meliputi hal-hal yang bertalian dengan: menyerang hampir semua incumbent (pelaku lama, para pemimpin pasar), menciptakan pasar baru yang selama ini diabaikan incumbent, menimbulkan dampak deflasi (penurunan harga) karena biaya mencari (searching cost) dan biaya transaksi (transaction cost) praktis menjadi nol rupiah, dan (5) implikasi disrupsi terhadap makna dan praktek pendidikan lebih terarah pada dibutuhkannya perubahan mindset pendidik, inovasi ruang kelas, revolusi model pembelajaran, dan pengubahan secara massif dan terstruktur kebijakan pembangunan pendidikan agar mampu melahirkan pendidik yang lebih literate terhadap teknologi digital serta memiliki teaching metacognition skill, yakni mengajarkan peserta didik bagaimana cara belajar yang benar agar dapat menjadi pembelajar mandiri bagi diri dan lingkungannya
PENERAPAN MODEL CONTEXTUAL TEACHING AND LEARNING SEBAGAI UPAYA MENINGKATKAN AKTIVITAS DAN PRESTASI BELAJAR PKN SISWA KELAS VIII 5 SMP NEGERI 2 SINGARAJA
Authors: Wiriawan Made
Published: June 2019

Tujuan utama penelitian ini adalah untuk memformulasi efektivitas model pembelajaran contextual teaching and learningdalam meningkatkan aktivitas belajar siswa dan prestasi belajar siswa kelas VIII 5 SMP Negeri 2 Singaraja. Secara metodologis penelitian ini menggunakan penelitian tindakan kelas (PTK) yang dilalui dengan tahapan perencanaan, pelaksanaan, observasi dan refleksi. Penelitian ini hanya menggunakan satu kelas. Adapun instrumen yang digunakan dalam penelitian ini adalah peneliti (human instrumen)dengan alat bantu pengumpul data berupa pedoman wawancara, pedoman observasi, tes prestasi belajar dan lembar observasi. Teknik analisis data yang digunakan dalam penelitian ini adalah deskriptif kualitatif.

Hasil penelitian menujukkan model pembelajaran contextual teaching and learningmampu meningkatkan prestasi belajar siswa.  Pada siklus I, dari 41 orang siswa hanya 16 orang siswa mendapat nilai di bawah kriteria ketuntasan minimal (KKM) dengan nilai terendah 55, dan  mengalami peningkatan pada siklus II, dimana hanya 5 orang  siswa yang mendapat nilai di bawah KKM dengan nilai terendah 60. Nilai rata-rata siswa sebelum dilakukan tindakan adalah sebesar  70,85 dan mengalami kenaikan  menjadi 74,42 pada kegiatan siklus I. Pada siklus II penerapan model pembelajaran contextual teaching and learningmampu meningkatkan prestasi belajar siswa menjadi 78,14. Model pembelajaran contextual teaching and learningjuga mampu meningkatkan aktivitas belajar siswa, dimana 25 ada pada kategori tuntas pada siklus I dan meningkat menjadi 38 orang pada siklus II. Hal ini disebabkan karena model pembelajaran mampu meingkatkan rasa ingin tahu siswa dan membangun semangat kerjasama siswa.
Eliminación de fluoxetina presente en aguas contaminadas usando procesos fotoquímicos de oxidación avanzada y luz solar
Authors: Manrique Losada Lis , Quimbaya Ñañez Carolina , Torres Palma Ricardo Antonio
Published: June 2019

Se estudió comparativamente la degradación de la fluoxetina por medio de tres procesos fotoquímicos de oxidación avanzada: foto Fenton (FFS), foto electro Fenton (FEFS) y fotocatálisis con TiO2 (FCS), mediados por radiación solar. Los experimentos se desarrollaron con soluciones de 100 mL en un vaso de reacción y para el caso de FEFS, se equipó el reactor con un ánodo de IrO2/RuO2 y un cátodo de grafito de difusión de aire para producción continua de peróxido. En todos los casos se hizo seguimiento de la degradación, la mineralización de la fluoxetina y la toxicidad. El proceso FFS presentó la mayor velocidad de degradación y mineralización, así como las mayores eficiencias en la degradación y mineralización. El pH en el proceso FFS definió el alcance de la mineralización, evidenciando que a pH ácido se logra mayor mineralización pues se evita la formación de complejos e hidróxidos típicos de un pH mayor. El proceso FCS presenta alta eficiencia, pero cinéticas lentas. La toxicidad ante levadura de cerveza disminuye a medida que se generan subproductos de degradación en todos los procesos evaluados.
“El otro” construido en el correo de lectores de La Nación
Authors: Basiuk Mauro
Published: June 2019

A diez años del conflicto que enfrentó al Gobierno Nacional con las entidades agropecuarias reunidas en la Mesa de Enlace, retomar las conclusiones derivadas del análisis del Correo de Lectores del Diario La Nación sirve para entender cómo se instalaron sentidos y significancias que posibilitaron el triunfo de la Alianza Cambiemos en 2015 y que sostienen el apoyo de su gestión en el ejercicio del Poder Ejecutivo.En aquel entonces, al discutirse la aplicación del régimen de retenciones móviles para los granos exportables, el Correo de Lectores de La Nación puso en escena, a través de textos, manifestaciones directas que el medio apropiaba en un vínculo que legitimaba al lector en ejercicio de su palabra y al diario como respetuoso del contrato de lectura por el cual respondía a sus deberes y obligaciones.
Programmable Dynamic Steady States in ATP-Driven Non-Equilibrium DNA Systems
Authors: Heinen Laura , Walther Andreas
Published: June 2019

Inspired by the dynamics of the dissipative self-assembly of microtubules, chemically fueled synthetic systems with transient lifetimes are emerging for non-equilibrium materials design. However, realizing programmable or even adaptive structural dynamics has proven challenging because it requires synchronization of energy uptake and dissipation events within true steady states, which remains difficult to orthogonally control in supramolecular systems. Here, we demonstrate full synchronization of both events by ATP-fueled activation and dynamization of covalent DNA bonds via an enzymatic reaction network of concurrent ligation and cleavage. Critically, the average bond ratio and the frequency of bond exchange are imprinted into the energy dissipation kinetics of the network and tunable through its constituents. We introduce temporally and structurally programmable dynamics by polymerization of transient, dynamic covalent DNA polymers with adaptive steady-state properties in dependence of ATP fuel and enzyme concentrations. This approach enables generic access to non-equilibrium soft matter systems with adaptive and programmable dynamics.
Further Evidence for Energy Landscape Flattening in the Superionic Argyrodites Li6+xP1−xMxS5I (M = Si, Ge, Sn)
Authors: Ohno Saneyuki , Helm Bianca , Fuchs Till , Dewald Georg , Kraft Marvin , Culver Sean , Senyshyn Anatoliy , Zeier Wolfgang
Published: June 2019

All-solid-state batteries are promising candidates for next-generation energy storage devices. Although the list of candidate materials for solid electrolytes has grown in the past decade, there are still many open questions concerning the mechanisms behind ionic migration in materials. In particular, the lithium thiophosphate family of materials has shown very promising properties for solid-state battery applications. Recently, the Ge-substituted Li6PS5I argyrodite was shown to be a very fast Li-ion conductor, despite the poor ionic conductivity of the unsubstituted Li6PS5I. Therein, the conductivity was enhanced by over three orders of magnitude due to the emergence of I−/S2−exchange, i.e.site-disorder, which led to a sudden decrease of the activation barrier with a concurrent flattening of the energy landscapes. Inspired by this work, two series of elemental substitutions in Li6+xP1−xMxS5I (M= Si and Sn) were investigated in this study and compared to the Ge-analogue. A sharp reduction in the activation energy was observed at the same M4+/P5+composition as previously found in the Ge-analogue, suggesting a more general mechanism at play. Furthermore, structural analyses with X-ray and neutron diffraction indicate that similar changes in the Li-sublattice occur despite a significant variation in the size of the substituents, suggesting that in the argyrodites, the lithium substructure is most likely influenced by the occurring Li+– Li+interactions. This work provides further evidence that the energy landscape of ionic conductors can be tailored by inducing local disorder.
In Vitro Sialylation of Recombinant Alpha-1-Antitrypsin using α2,6 Sialyltransferase from Photobacterium Damselae Produces Di-sialyl Galactose Motifs in N-Glycans
Authors: Pallister Edward , Choo Matthew , tai jien nee , leong Dawn , Tang Wen-Qin , Ng Say-Kong , Huang Kun , Marchesi Andrea , Both Peter , Gray Chris , Rudd Pauline , Flitsch Sabine , Nguyen-Khuong Terry
Published: June 2019

Sialic acids are cell surface sugars present in many animal glycoproteins and are of particular interest in biopharmaceuticals, where lack of sialylation can reduce bioactivity. Here we describe how α-2,6-sialyltransferase from Photobacterium Damselae can be used to markedly increase sialylation of CHO produced alpha-1-antitrypsin. Detailed analysis of the sialylation products showed that in addition to the expected α-2,6-sialylation of galactose, a second di-sialyl galactose motif was produced, which had never been recorded on a mammalian glycoprotein. The influence of this unique di-sialylation on the in vitro activity of alpha-1-antitrypsin was studied and a toolkit of mass spectrometry methods to identify this new di-sialyl galactose motif in complex mixtures was developed
MasterMSM: A Package for Constructing Master Equation Models of Molecular Dynamics
Authors: De Sancho David , Aguirre Anne
Published: June 2019

Markov state models (MSMs) have become one of the most important techniques for understanding biomolecular transitions from classical molecular dynamics (MD) simulations. MSMs provide a systematized way of accessing the long time kinetics of the system of interest from the short-timescale microscopic transitions observed in simulation trajectories. At the same time, they provide a consistent description of the equilibrium and dynamical properties of the system of interest, and they are ideally suited for comparisons against experiment. A few software packages exist for building MSMs, which have been widely adopted. Here we introduce MasterMSM, a new Python package that uses the master equation formulation of MSMs and provides a number of new algorithms for building and analyzing these models. We demonstrate some of the most distinctive features of the package, including the estimation of rates, definition of core-sets for transition based assignment of states, the estimation of committors and fluxes, and the sensitivity analysis of the emerging networks. The package is available at https://github.com/daviddesancho/MasterMSM.
Redox-Active Heteroacene Chromophores Derived from a Non-Linear Aromatic Diimide
Authors: Luo Stella , Stellmach Kellie , Ikuzwe Stella , Cao Dennis
Published: June 2019

This work describes a three-step chromatography-free protocol for the synthesis of a novel organic materialsbuilding block, dichlorinated mellophanic diimide (MDI), that is shown to undergo nucleophilic substitutionwith a variety of ortho disubstituted benzenes to yield a series of chromophores. Furthermore, 1,2,4,5-tetrasubstituted benzenes can be used to synthesize tetraimide heteropentacene derivatives endcapped byMDI motifs. The fine-tuning effects of heteroatom identity were investigated by UV-Vis and fluorescencespectroscopy, cyclic and differential pulse voltammetries, and density functional theory calculations. Oxidationof diamino MDI derivatives yields di- and tetraimide functionalized azaacenes with significantly lowered LUMOlevels (down to –4.49 eV), narrowed bandgaps (down to 1.81 eV), and high molar absorptivities (up to 84,000M–1 cm–1).
Activation Energy and NBO Interaction Approaches to the Determination of the Relative Resonance Acceptor Strengths of CN, NO, COMe, CHO and NO2 Groups from the Ring-Opening of 1,2-Benzo-3-Carbomethoxycyclobutenes
Authors: Yadav Veejendra , Yadav Arpita
Published: June 2019

The relative resonance-acceptor ability based on the activation energies for the outward ring-openings of 1,2-benzo-3-carbomethoxycyclobutenes bearing CN, NO, COMe, CHO and NO2 as C6 and C7 substituents is different from that based on the sC3C4-p*C1C2 interactions in the inward opening transition structures. The differential activation energy (∆G‡) predicts outward ring-opening and, in contrast, the differential sC3C4-p*C1C2 interaction energy predicts inward opening, throughout. The relative resonance-acceptor ability estimated from the sC3C4-p*C1C2 interaction energies is more realistic than that from the activation energies.
Multipolar/Polarizable Molecular Dynamics Simulations of Liquid-Liquid Extraction of Benzene from Hydrocarbons Using Ionic Liquids
Authors: Vazquez-Montelongo Erik A. , Cisneros G. Andres , Flores Hugo
Published: June 2019

We used AMOEBA to explore the capacity of 1,3 dimethylimidazolium tetrafluorobrorate, [DMIM][BF4], and ethyl-methylimidazolium tetrafluorobrorate, [EMIM][BF4], to extract benzene from a mixture of benzene-dodecane. Our results indicate that [DMIM][BF4] exhibits better selectivity and provide structural insights on possible reasons for the observed preference.
Ultra-High to Ultra-Low Drug Loaded Micelles: Probing Host-Guest Interactions by Fluorescence Spectroscopy
Authors: Lübtow Michael M , Marciniak Henning , Schmiedel Alexander , Roos Markus , Lambert Christoph , Luxenhofer Robert
Published: June 2019

Polymer micelles are an attractive means to solubilize water insoluble compounds such as drugs. Drug loading, formulations stability and control over drug release are crucial factors for drug loaded polymer micelles. The interactions between the polymeric host and the guest molecules are considered critical to control these factors but typically barely understood. Here, we compare two isomeric polymer micelles, one of which enables ultra-high curcumin loading exceeding 50 wt.%, while the other only allows a drug loading of only 25 wt.%. In the low capacity micelles, steady-state fluorescence revealed a very unusual feature of curcumin fluorescence, a high energy emission at 510 nm. Time-resolved fluorescence upconversion showed that the fluorescence life time of the corresponding species is too short in the high-capacity micelles, preventing an observable emission in steady-state. Therefore, contrary to common perception, stronger interactions between host and guest can be detrimental to the drug loading in polymer micelles.
O prescrito e o vivido na formação dos oficiais militares estaduais
Authors: Sena Getúlio Neves , Abranches Ana de Fátima Pereira de Sousa
Published: June 2019

O artigo apresenta um estudo sobre o currículo do Curso de Formação de Oficiaisde Bombeiro Militar de Pernambuco, baseado na mudança proposta na MatrizCurricular Nacional para a formação dos profissionais de segurança pública.Neste contexto, a reforma de ensino desenvolvida nas instituições militares deixade ter um foco militarista, com ênfase na defesa nacional e abraça princípios maishumanos visando aproximar a população das instituições de segurança pública.Os dados coletados evidenciam a necessidade de serem repensados o novoperfil, a identidade e as competências do Bombeiro Militar, a inserção social e afalta de contextualização dos conteúdos.
Sistematização da tabuada em duas proposições de ensino
Authors: Rosa Josélia Euzébio da , Hobold Ediséia Suethe Faust
Published: June 2019

Investigamos o movimento de sistematização da tabuada proposta em dois livros didáticos do segundo ano do ensino fundamental, um brasileiro e outro russo. Constatamos que as duas proposições seguem movimentos distintos. Na brasileira, a tabuada surge a partir da observação das quantidades. A essência conceitual resulta da aparência externa dos agrupamentos, carente de análise nas relações que geram sua lógica interna. Na proposição russa, por sua vez, o ensino da tabuada contempla a inter-relação das significações aritméticas, algébricas e geométricas no movimento que envolve o geral, universal, particular e singular, a partir das relações entre grandezas discretas e contínuas.
Evento de reproducción y depredación de la Gaviota Andina Chroicocephalus serranus (Charadriiformes: Laridae) en Tucumán, Argentina
Authors: Quiroga Oscar Bernardo
Published: June 2019

La distribución de la Gaviota Andina abarca once provincias argentinas, desde el norte hasta la Patagonia, donde habita espejos de agua altoandinos, tales como lagos y lagunas, entre los 3000 y 4000 msnm. En nuestro país su biología ha sido escasamente estudiada, se conocen datos de reproducción solamente en cinco provincias; también su alimentación e interacciones con otros organismos presentan pocos registros, siendo una especie oportunista, alimentándose de invertebrados, peces, carroña, huevos y pichones de aves. En la provincia de Tucumán se la observa en localidades de altura, aunque en invierno desciende hasta los 2000 msnm, movimientos estacionales que fueron comprobados en un estudio de la avifauna en un embalse de la provincia. Visitamos el embalse La Angostura, departamento Tafí del Valle, Tucumán, donde tomamos datos de nidos, huevos, pichones y adultos de diversas especies de aves. Registramos una pequeña colonia reproductiva de seis individuos, tres nidos y dos pichones, además presenciamos eventos depredatorios sobre gallaretas. En este trabajo documentamos la nidificación de este lárido en la provincia de Tucumán, describimos a los pichones y damos a conocer una nueva víctima de depredación de esta gaviota para Argentina. Futuros estudios sobre la reproducción de esta gaviota resultan de interés ya que seleccionaría distintos sitios para nidificar.
Adecuación, viralidad e interacción de la información contenida en YouTube sobre el tratamiento de las enfermedades de transmisión sexual curables
Authors: Sanz-Lorente María , Chorro-Vicedo María , Sanz Javier , Wanden-Berghe Carmina
Published: June 2019

Objetivo: Evaluar la adecuación, viralidad/popularidad e interacción de la información contenida en YouTube sobre el tratamiento de las enfermedades de transmisión sexual. Método: Estudio descriptivo transversal en el que se estudió la información sobre el tratamiento de las enfermedades de transmisión sexual (ETS), principalmente curables, recuperada de los videos contenidos en la edición española de YouTube. Se realizó una búsqueda simple mediante los términos, «tratamiento», «enfermedad sexual», «sífilis», «gonorrea», «clamidia», «tricomoniasis». La fecha fin del visionado y consulta fue el 26 de septiembre de 2018. Resultados: Se probó una evolución creciente en el número de vídeos subidos a YouTube, confirmando un modelo con ajuste lineal según año de promoción (coeficiente de determinación R2 = 0,47; p = 0,001). La edad media del conjunto de los videos sobre tratamiento de las ETS fue de 2,79 ± 0,22 años, con mediana de 2 y AIQ igual a 2 años, máximo de 10 y mínimo de 0 años. La relación media de aceptación fue del 88,09 ± 1,10 %, con mediana igual a 90,83%, AIQ de 8,62%, máximo del 100% y mínimo del 50%. La ETS que más se observó fue la gonorrea, bien sola (20; 25,00%) bien junto a la sífilis (2; 2,50%). El remedio más utilizado en los videos sobre ETS fue el medicamento registrado en 59 (73,75%) ocasiones, el principio activo más presente fue un conjunto de ellos en 28 (35,00%) videos y la forma farmacéutica más utilizada fue también un conjunto de ellas en 28 (35,00%) casos. Conclusiones: Se consideró pertinente hacer más activo al profesional sanitario en la Web 2.0, y concretamente, en YouTube. Se advirtió también muy importante que el profesional sanitario pase a ser creador de contenido a un nivel similar al que mostraron los canales de divulgación, y de igual modo, lograr que los pacientes verifiquen y complementen la información de video de YouTube en consultas con sus profesionales de atención médica.
La radio como herramienta para mejorar la expresión oral del alumnado en la enseñanza secundaria
Authors: Vila Rodríguez Miriam
Published: June 2019

En este artículo se analiza la utilidad de la radio como herramienta didáctica para mejorar la expresión oral del alumnado de secundaria. En este medio de comunicación, la voz (la palabra) es la protagonista junto con la música y los efectos de sonido. Por esta razón se trata de un recurso ideal para ejercitar los elementos prosódicos y poner de manifiesto su relevancia en la comunicación por vía oral.La unidad didáctica, presentada de manera condensada en este artículo, se ha llevado a la práctica con un grupo de tercero de la ESO, pero se puede adaptar para trabajar en el resto de niveles. El objetivo final de esta propuesta es la grabación de un programa de radio. Para ello se necesita un número de sesiones previas que permitan al alumnado adquirir los conocimientos requeridos para acometer esta tarea: hablar ante un micrófono, prestando atención a la pronunciación y a la velocidad elocutiva, redactar un guion radiofónico, seleccionar las músicas que darán paso a cada sección, etc.
El acceso a la literatura clásica a través de la literatura juvenil contemporánea: estado de la cuestión
Authors: Martín García Lorena
Published: June 2019

La lectura de la literatura clásica en los niveles de Educación Secundaria Obligatoria y de Bachillerato es un tema que se viene tratando desde hace mucho tiempo y sobre el que han expresado su opinión, a favor o en contra, los diferentes docentes de Lengua Española y Literatura. La discusión se centra en torno a la obligatoriedad de este tipo de obras, desde el momento en que los alumnos, a la hora de enfrentarse a obras pertenecientes a la literatura clásica, pueden haber tenido una mala experiencia al no comprenderlas y, sin embargo, tener que leerlas de forma obligatoria porque supone una calificación en la asignatura. Sin embargo, también es cierto que no se puede llegar a la Universidad sin haber conocido ciertos títulos imprescindibles para nuestra cultura. Las posibilidades son muy numerosas, pues hay muchos libros de literatura juvenil que forman parte del canon literario y cumplen las características que todo docente cree necesarias para aproximar a los estudiantes a este tipo de obras clásicas.
Конъюгаты на основе лигандов простатического специфического мембранного антигена с противоопухолевыми препаратами
Authors: Успенская Анастасия Алексеевна , Мачулкин Алексей Эдуардович , Мажуга Александр Георгиевич , Белоглазкина Елена Кимовна
Published: June 2019

В связи с недостатками имеющихся методов лечения и диагностики рака предстательной железы широкое применение и развитие получили конъюгаты для селективной доставки на основе низкомолекулярных ингибиторов простатического специфического мембранного антигена (ПСМА). Рассмотрены основные классы низкомолекулярных ингибиторов ПСМА, а также классы лекарственных препаратов и принципы их действия, проанализированы созданные на их основе терапевтические конъюгаты для адресной доставки, выявлены структурные особенности линкера, влияющие на биологическую активность и селективность.
Препарат инсулина для регулирования уровня глюкозы в крови
Authors: Валуев Иван Львович , Старосельцева Людмила Константиновна , Валуев Лев Иванович , Ванчугова Людмила Витальевна
Published: June 2019

Изучен новый подход, обеспечивающий проникновение активного инсулина в кровоток через пищеварительную систему при пероральном введении животным с экспериментальным диабетом разбавленных растворов инсулина. Показано, что при использование таких растворов реализуется физиологический путь поступления инсулина в кровь.
Оценка противопаркинсонической, противовоспалительной и противоболевой активности 2 производных 2-аминоадамантана, отличающихся между собой наличием гидроксильной группы в узловом положении адамантана, в сравнении с гимантаном
Authors: Капица Инга Геннадиевна , Иванова Елена Анатольевна , Авдюнина Нина Ивановна , Воронина Татьяна Александровна
Published: June 2019

На моделях паркинсонического синдрома у мышей установлено, что 2-адамантиламинопропанола гидрохлорид (соединение АДК-971) и 5-гидроксиадамантан-2-иламинопропанола гидрохлорид (соединение АДК-1013) обладают менее выраженным противопаркинсоническим действием, чем гимантан. АДК-971 и АДК-1013, как и гимантан в дозе 20 мг/кг, проявляют сопоставимый антиэкссудативный эффект на модели уксусного перитонита у мышей. Однако в отличие от гимантана в дозе 20 мг/кг АДК-971 и АДК-1013 в такой же дозе не обладают противоболевым действием как в отношении висцеральной, так и термической соматической боли у мышей.
Challenges on digital economy in sample of various income economies as an development instrument in Uzbekistan
Authors: Gulirano Ibragimova , Dilorom Husnuddinova , Khurshida Akhmatova , Dildor Shodibekova
Published: June 2019

Recent economic changes have developed via modern technological prospective. Consistent measures for the development of digital economy are being implemented gradual introduction of e-commerce systems for electronic document flows and service of individuals. However, find solutions for the lack of a unified information and technology platform, which integrates the centralized information by just one digital economic reform in world regions. After the global financial crisis of 2001–2009 years, digital industries have been amid the most dynamic and promising in the global economy. However, equilibrium is lacked of benefits and risks in the digital economy around the world, which explains the need for global governance in this sphere. In this article authors analyzed main role and characteristics of digital economy around average income countries. Generally, reviewing define the key characteristics of this sector, as well as highlight the challenges to international cooperation. Modern approaches on legal entities is being implemented in Uzbekistan for further development.
Marrying Neo-Chicago and Behavorial Antitrust
Authors: Huffman Max
Published: June 2019

78 Antitrust Law Journal 105 (2012)
Tuberculosis Mamaria
Authors: Cruz Castillo Yessenia Magaly , Moreira Granda Edison Javier , Saavedra Verduga David Josué , Obando Navas Jose Luis
Published: June 2019

Introducción: Sir Astley Cooper en 1829 reportó por primera vez un caso de tuberculosis (TB) mamaria, con el nombre de “Inflamación escrofulosa del seno”. Hoy la incidencia de TB mamaria es baja, representando menos del 0,1% de la patología mamaria y 3 % de lesiones benignas tratables.

Objetivo: Describir un caso clínico de Tuberculosis mamaria.

Material y métodos: Se realizó un estudio descriptivo, retrospectivo, presentación de caso clínico sobre Tuberculosis mamaria.

Resultados: Se describe el caso de una paciente femenina de 30 años, atendida en el Hospital Regional Ambato, con antecedentes de tuberculosis mamaria izquierda, que presenta masa mamaria derecha con secreción purulenta por la aerola ipsilateral. Se le realiza Ecografía de mamas que demostró proceso inflamatorio tipo mastitis granulomatosa. Se continuó su estudio realizando PBAF y en la tinción de Ziehl Neelsen de la muestra se observaron Bacilos de Koch, que confirmaron el diagnóstico de Tuberculosis mamaria.

Conclusiones: La Tuberculosis mamaria es una patología poco frecuente en nuestro medio. Las manifestaciones clínicas con las que se presenta el paciente no son específicas y puede ser fácilmente confundida con otras enfermedades. La tinción de Ziehl Neelsen y el PCR son las pruebas recomendadas para el diagnóstico, aunque no son específicas, pudiendo ocasionar falsos negativos. El médico debe tener alta sospecha de tuberculosis mamaria en pacientes con lesiones crónicas resistentes al tratamiento y que han sido descartadas para enfermedades neoplásicas