bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Case of Recurrent Mucinous Borderline Ovarian Tumor: Early Relapse and Fatal Outcome
Authors: Nakagawa Kyoko , Nakayama Kentaro , Nakamura Akiho , Hadano Nagisa , Kurose Sonomi , Razia Sultana , Aoki Showa , Kyo Satoru
Published: May 2022

Unlike ovarian carcinomas, borderline ovarian tumors (BOTs) are associated with a favorable prognosis: their recurrence rate is around 5–7%, and the survival rate is more than 97% when diagnosed early. There are only a few reports of recurrence and fatal outcomes. Herein, we report a novel case of recurrent mucinous BOT, with a literature review. A 63-year-old woman presented to a local doctor with abdominal fullness. She was diagnosed as having a polycystic tumor. The lesion was suspected to be a mucinous BOT (M-BOT) on magnetic resonance imaging. Upper and lower gastrointestinal endoscopy revealed no digestive cancerous lesions, and surgery was performed. Intra-operative diagnosis confirmed the diagnosis, and total abdominal hysterectomy, bilateral salpingo-oophorectomy, and omentectomy were performed. The final pathological diagnosis was non-invasive M-BOT (stage I c1 (T1c1N0M0)). The result of immunohistochemical staining supported the diagnosis of primary ovarian mucinous tumor.Four months after surgery, relapse occurred. Blood tests revealed an elevated carbohydrate antigen 19-9 level, and computed tomography revealed multiple liver metastases, peritoneal dissemination, left ureter infiltration, and carcinomatous peritonitis. Although the patient underwent chemotherapy, she died. This case of a very short progression-free and overall survival in stage I M-BOT indicates that some M-BOTs could result in fatal clinical outcomes despite diagnosis at an early stage. Frequent follow-up appointments after surgery could help detect relapse and increase survival in such cases.
The Ratio of Biologically Vital Areas as a Measure of the Sustainability of Urban Parks Using the Example of Budapest, Hungary
Authors: Kimic Kinga , Fekete Albert
Published: May 2022

Biologically vital areas (BVAs) indicate regions with ecological functions within cities. Their presence in green spaces helps to counteract the negative impacts of built-up areas and impermeable structures on urban environments and city dwellers. The main objective of this study was to examine the level of sustainability of urban parks based on their real ratio of biologically vital areas (RBVA). The preliminary research was conducted in 2021 on six randomly selected parks in Budapest, Hungary, which are examples either of site rehabilitation or of new designs based on a sustainable approach. The areas of the main types of landcover with ecological functions, such as greenery planted on the ground, green roofs, permeable pavement, and water reservoirs, were measured and compared to the area of hard structures as well as the entire area of each park. The results show that the RBVA was below 50% in four of the six studied cases (ranging from 22.97% in MOM Park to 44.13% in Millenáris Park) and above 50% in two cases (51.52% in Graphisoft Park and 79.31% in Nehru Park). This diversity resulted from the need to reconcile ecological and social functions in urban parks; however, the implementation of sustainable solutions should be increased in further development.
Assessment of the Interconnection for Multi-Transfer Facilities: A Perspective from Coupling Coordination
Authors: Chen Lijun , Zhang Haiping , Lu Weike
Published: May 2022

Transfer terminals with a high integration level could provide favorable support to Mobility-as-a-Service, which is essential to sustainable transportation. The interconnection of multiple transfer facilities in terminals would affect travelers’ transfer choices during their trips. Existing research on intermodality lacks an efficient multi-dimension indicator system regarding transfer facilities. To date, the selection of representative indicator systems and the construction of quantitative evaluation models based on these indicators that can reflect the coupling relationship between transfer facilities effectively and comprehensively are still challenging. Aiming at this challenge, this study conducts the work in the following three ways. First, the concept of the degree of coupling coordination of multiple transfer facilities (DCC-MTF) is proposed to evaluate the interaction among multiple transfer facilities. Second, indicators of diversity, selectivity, accessibility, and continuity are designed and used to establish the model by using the entropy weight method. Third, the spatial distribution characteristics of DCC-MTF for each transfer facility are geo-visualized and clustered. Field observation is conducted at Lelylaan Station in the city of Amsterdam, and the indicator analysis derived from the collected data is discussed. Overall, the quantitative evaluation model presented in this study, which is universal and can be applied to similar scenarios, is directly valuable for planners and designers who aim to improve the integration level of transfer terminals.
Toward Identifying Sustainability Leadership Competencies: Insights from Mapping a Graduate Sustainability Education Curriculum
Authors: Killion Alexander K. , Ostrow Michel Jessica , Hawes Jason K.
Published: May 2022

Graduate sustainability programs are tasked with educating and preparing the next generation of leaders to address the causes and effects of global climate change. As the urgency of addressing sustainability challenges like climate change has grown, including through higher education sustainability education, so has the attention on the competencies students ought to master to become sustainability leaders. Yet little is known about which sustainability leadership competencies are critical to bring about change or how curricula are addressing them. We used course descriptions from the University of Michigan’s School for Environment and Sustainability, to identify the sustainability leadership competencies targeted across its historically successful graduate curriculum, along with faculty members’ associated cognitive processing expectations following Bloom’s Taxonomy. The programs’ courses varied in the extent to which they addressed ten leadership competencies but were consistent in terms of associated cognitive processing expectations. We recommend that other sustainability education programs similarly examine their curricula and ensure that students regardless of their specializations have the opportunity to graduate with the knowledge, skills, and mindsets to affect change.
Critical Success Factors for Circular Business Model Innovation from the Perspective of the Sustainable Development Goals
Authors: Benz Lukas Alexander
Published: May 2022

Circular business model innovation offers a path for the transformation of companies, enhancing resource productivity and efficiency, while also contributing to sustainable development. These fundamental changes in business are accompanied by a variety of challenges and barriers. To support companies on their journey, only a few studies have investigated the critical success factors for circular business model innovation through literature analysis. To contribute to this research, in this study, a methodological approach, mainly based on expert interviews, is proposed to gain in-depth insight into critical success factors for circular business model innovation. As a result, a framework covering critical success factors for circular business model innovation is developed, comprising nine top-codes and 37 sub-codes, and an analysis of each factor’s contribution to the UN’s Sustainable Development Goals is performed. The study thereby extends the theoretical basis for further research on circular business model innovation, as well as identifies their practical implications.
Energy Transition in France
Authors: Lebrouhi Badr Eddine , Schall Eric , Lamrani Bilal , Chaibi Yassine , Kousksou Tarik
Published: May 2022

To address the climate emergency, France is committed to achieving carbon neutrality by 2050. It plans to significantly increase the contribution of renewable energy in its energy mix. The share of renewable energy in its electricity production, which amounts to 25.5% in 2020, should reach at least 40% in 2030. This growth poses several new challenges that require policy makers and regulators to act on the technological changes and expanding need for flexibility in power systems. This document presents the main strategies and projects developed in France as well as various recommendations to accompany and support its energy transition policy.
Application of Multifractal Analysis in Estimating the Reaction of Energy Markets to Geopolitical Acts and Threats
Authors: Aslam Faheem , Ferreira Paulo , Ali Haider , José Ana Ercília
Published: May 2022

Since the industrial revolution, the geopolitics of energy has been a driver of global prosperity and security, and determines the survival of life on our planet. This study examines the nonlinear structure and multifractal behavior of the cross-correlation between geopolitical risk and energy markets (West Texas Intermediate (WTI), Brent, natural gas and heating oil), using the multifractal detrended cross-correlation analysis. Furthermore, an in-depth analysis reveals different associations of the indices of overall geopolitical risk, geopolitical acts, and geopolitical threats against the four energy products. Based on daily data ranging from 1 January 1985 to 30 August 2021, the findings confirm the presence of nonlinear dependencies, suggesting that geopolitical risk and energy markets are interlinked. Furthermore, significant multifractal characteristics are found and the degree of multifractality is stronger between the overall geopolitical risk and WTI while the lowest degree of multifractality is with Brent. Overall, for the WTI and heating-oil markets, the influence of geopolitical threats is more pronounced rather than their fulfilment. Contrarily, the Brent and natural gas are more correlated to geopolitical acts. Energy products exhibit heterogeneous persistence levels of cross-correlation with all the indicators of geopolitical risk, being more persistent in the case of small fluctuations compared to large fluctuations.
Fuzzy Comprehensive Evaluation Model of the Farmers’ Sense of Gain in the Provision of Rural Infrastructures: The Case of Tourism-Oriented Rural Areas of China
Authors: Jia Hongtao , Zhu Lei , Du Jing
Published: May 2022

During the rapid development of rural infrastructures in China, many important issues such as the real wishes of farmers and the proper management of the infrastructure have been overlooked, resulting in a weak sense of gain among farmers. To propose effective improvement strategies, this research aimed to explore the influence mechanism of the farmers’ sense of gain and to build a comprehensive evaluation model of farmers’ sense of gain in the provision of rural infrastructure. To achieve the above aims, we first proposed hypotheses among four constructs and selected an evaluation index for each construct. Using Structural Equation Modeling (SEM) and a questionnaire survey, we then verified the proposed hypotheses and developed a fuzzy comprehensive evaluation model of the farmers’ sense of gain in the provision of rural infrastructure. The results first showed that the content of gain and the way of gain directly affect the farmers’ sense of gain, and the governance indirectly affects the farmers’ sense of gain. Moreover, the way of gain has the greatest impact on the sense of gain, followed by the governance and the content of gain. Furthermore, the analysis results demonstrate that the developed fuzzy comprehensive evaluation model is feasible and effective in evaluating farmers’ sense of gain in the provision of rural infrastructures. The findings of this study first enrich the relevant theories of farmers’ sense of gain in the provision of rural infrastructure. The findings also provide theoretical support for the government authorities to put forward effective governance strategies for rural infrastructure from the perspective of farmers’ sense of gain.
Forecasting Liquidated Damages via Machine Learning-Based Modified Regression Models for Highway Construction Projects
Authors: Alshboul Odey , Alzubaidi Mohammad A. , Mamlook Rabia Emhamed Al , Almasabha Ghassan , Almuflih Ali Saeed , Shehadeh Ali
Published: May 2022

Sustainable construction projects are essential for economic and societal thriving in modern communities. However, infrastructural construction is usually accompanied by delays in project delivery, which impact sustainability. Such delays adversely affect project time, cost, quality, safety objective functions, and associated Liquidated Damages (LDs). LDs are monetary charges to recompense the owner for additional expenses sustained if the project was not delivered on time due to delays caused by the contractor. This paper proposes modified regression modeling using machine learning (ML) techniques to develop solutions to the problem of predicting LDs for construction projects. The novel modeling methodology presented here is based on six years of data collection from many construction projects across the United States. It represents an innovative use of Multiple Linear Regression (MLR) models hybridized with machine learning (ML). The proposed methodology is evaluated using real datasets, where the developed model is designed to outperform the state-of-the-art LD forecast accuracy. Herein, seven modified regression-based models showed high accuracy in predicting the LDs. Nevertheless, those models’ forecasting ability was limited, so another second-order prediction model is proposed to provide better LD estimations. Independent variables were categorized based on their influence on the estimated LDs. The Total Bid Amount variable had the highest impact, while the Funding Indicator variable had a minimal impact. LD prediction was negatively correlated with all change-order-related variables and Total Adjustment Days, which suggests that those variables introduce extreme uncertainties due to their complex nature. The developed prediction models help decision-makers make better LDs predictions, which is essential for construction project sustainability.
Sustainable Hybrid Business Model of Benefit Corporation: The Case of an Italian Film Production Company
Authors: Ferlito Rosaria , Faraci Rosario
Published: May 2022

In the last decade, individual awareness of the impacts generated by the activities of businesses has increased more than ever. Consumers, employees and investors have begun to criticize business behaviors that negatively affect either society or the environment. Given this context, and relying on the literature relating to hybrid organizations and sustainable business models, our research aims to investigate how dual logic affects the business model of benefit corporations in the Italian film production industry. To capture the complexity of this type of firm, we adopted a qualitative research method, the case study approach. The case selected was ARE FILMS srl, a creative film production company. It has been a benefit corporation since it was founded. The study suggests that the capacity of hybrid businesses to achieve a hybrid mission is intrinsically embedded in their business model. A young film production benefit corporation is more likely to adopt a semi-integrated business model that does not create an external perception of dual corporate identity and does not affect economic sustainability. Moreover, the sustainable value proposition emerges even without the formal application of accepted protocols. Furthermore, we realized that the size of the firm affects business modelling. Finally, this research underlines the fact that benefit corporations do not require external pressure to implement sustainable practices.
Proposal of New Strategies for Smart Tourism Destinations in the Challenging New Reality: A Commitment to the Technology–Sustainability Binomial
Authors: García Revilla Mercedes Raquel , Perogil Burgos Javier , Einsle Carmen Sarah , Martinez Moure Olga
Published: May 2022

This paper aimed to investigate the response of smart tourism destinations (STDs) to the COVID-19 crisis, specifically regarding sustainability, which—along with information, new technologies, and governance—is a key element of STDs. First, we conducted a brief literature review regarding tourism sustainability. Secondly, we performed a case study of several STDs to determine the sustainable actions implemented in response to the current crisis, the results of which are presented in this paper. Thirdly, we assessed these STDs’ primary sustainability actions and developed a strategy proposal that can be followed by destinations in similar situations. This proposal is intended to be evaluated by the studied STDs for validation or adaptation. Far from a definitive solution, our proposal was designed as one possible tool to avoid the disorganisation and uncertainty suffered in crisis situations such as the COVID-19 pandemic.
Factors Influencing Consumer Attitudes towards Organic Food Products in a Transition Economy—Insights from Kosovo
Authors: Miftari Iliriana , Haas Rainer , Meixner Oliver , Imami Drini , Gjokaj Ekrem
Published: May 2022

Globally, organic food production and consumption have significantly increased in the last two decades, driven largely by perceived positive impacts on consumer health, the environment, and sustainable development. The aim of this study was to investigate factors influencing consumers’ attitudes towards organic food in the context of a transition/emerging economy. The study is based on a structured consumer survey targeting 300 urban consumers in Kosovo. Structural Equation Modeling (SEM) by Partial Least Squares was used to analyze factors influencing consumers’ attitudes towards organic food products, measured with four items (health concerns, labeling of origin, certification, environmental concerns). The results indicate that the health concerns, certification, and environmental concerns significantly influence consumers’ attitudes towards organic food products. The findings of this study are important for both producers and authorities responsible for ensuring the provision of healthy and reliable certified organic food products as well as environmentally friendly production systems that contribute to sustainable development.
Effects of Increasing Concentrations of Enrofloxacin on Co-Digestion of Pig Manure and Corn Straw
Authors: Shu Qihang , Cheng Hongkuan , Chen Xiaxia , Wang Jie , Du Zunqing , Hong Jun , Zheng Zheng , Luo Xingzhang
Published: May 2022

Enrofloxacin (ENR) is one of the most commonly used antibiotics in pig farms. In this study, using fresh pig manure and corn straw powder as substrates, the effects of different concentrations of ENR (2.5, 10, and 20 mg/L) on anaerobic digestion in completely mixed anaerobic reactors were investigated. A relatively low concentration of ENR (2.5 mg/L) increased methane production by 47.58% compared with the control group. Among the volatile fatty acids (VFAs) in the reactors, the propionic acid content was the lowest, and the concentrations of acetic acid kinase and coenzyme F420 were highest in the first seven days during peak gas production. However, methane production in the reactors with 10 mg/L and 20 mg/L ENR decreased by 8.59% and 20.25%, respectively. Furthermore, the accelerated hydrolysis of extracellular polymeric substances causes a significant accumulation of VFA levels. The microbial community in anaerobic reactors was analyzed by 16S rRNA sequencing. Proteiniphilum was the dominant bacterial genus. In addition, ENR at 2.5 mg/L effectively increased the abundance and diversity of anaerobic microorganisms, whereas a high concentration of ENR (10 and 20 mg/L) significantly decreased these parameters. This study demonstrated that different concentrations of ENR had significantly different effects on anaerobic digestion.
An Efficient Red–Black Skewed Modified Accelerated Arithmetic Mean Iterative Method for Solving Two-Dimensional Poisson Equation
Authors: Saudi Azali , Dahalan A’qilah Ahmad
Published: May 2022

This paper presents the extended variants to the established two-stage Arithmetic Mean (AM) method known as the Modified Accelerated Arithmetic Mean (MAAM) and Skewed Modified Accelerated Arithmetic Mean (SkMAAM) methods to solve the two-dimensional elliptic problem. The existing two-stage AM and its skewed variants apply one weighted parameter for the computation of nodes in Levels 1 and 2. The suggested MAAM and SkMAAM methods employ red–black ordering with two different weighted parameters and an additional two distinct accelerated parameters for red and black nodes, respectively. By carefully choosing optimum parameter values, the proposed MAAM and SkMAAM improve the computational execution of the algorithm. With red–black ordering, the computational molecules of red and black nodes are symmetrical, in which the computation of red nodes applies the updated values of their four neighbouring black nodes and vice versa. These symmetrical computational molecules of red and black nodes can be seen for the modified variants MAM and MAAM, and their corresponding skewed variants SkMAM and SkMAAM. The proposed MAAM and SkMAAM methods are compared to the existing AM and Modified AM (MAM) and their corresponding skewed variants, namely the Skewed AM (SkAM) and Skewed MAM (SkMAM) methods. The performance of the newly proposed MAAM and SkMAAM methods is compared against the existing methods in terms of computational complexity and actual execution time. It is shown in the simulation results that the skewed variants are superior to their corresponding regular variants, in which the SkMAAM method gives the best performance.
Online Teaching Quality Evaluation of Business Statistics Course Utilizing Fermatean Fuzzy Analytical Hierarchy Process with Aggregation Operator
Authors: Zeng Shouzhen , Pan Yan , Jin Huanhuan
Published: May 2022

Due to the full-scale outbreak of COVID-19, many universities have adopted the way of online teaching to ensure the orderly development of teaching plans and teaching contents. However, whether online and offline teaching can develop homogeneously and how to ensure the teaching effect is a major challenge for colleges and universities. Therefore, it is urgent to construct a reasonable index system and evaluation approach for the quality of network teaching. Combined with the influencing factors and characteristics of online teaching, this study first puts forward a multi-index evaluation index system and then proposes a novel evaluation method for online teaching based on the analytical hierarchy process (AHP) and Dombi weighted partitioned Muirhead Mean (PMM) operator under Fermatean fuzzy (FF) environment. This presented method not only adapts to changeable evaluation information but also handles the elusive interrelationships among indexes, realizing the flexibility and comprehensiveness both in form and in the polyaddition process. The applicability and feasibility of this presented method are then discussed through the practical online teaching quality evaluation of a business statistics course case, and a group of tentative about the sensitivity analysis and comparative analysis further demonstrates the effectiveness and flexibility of the proposed method.
Second Wave of the Study of Taiwanese Caregivers of Children with ADHD in the COVID-19 Pandemic: Intentions to Vaccinate Their Children for COVID-19, and Related Factors
Authors: Tsai Ching-Shu , Wang Liang-Jen , Hsiao Ray C. , Yen Cheng-Fang
Published: May 2022

The second wave of the Study of Taiwanese Caregivers of Children with Attention-Deficit/Hyperactivity Disorder (ADHD) in the COVID-19 Pandemic was conducted at the time of a severe COVID-19 outbreak. The aims of this study were to compare the level of the intentions of caregivers of children with ADHD to vaccinate their children between the first and second waves of study, as well as to examine the COVID-19 pandemic and non-COVID-19 pandemic factors related to caregivers’ intentions. In total, 252 caregivers of children with ADHD completed the structured questionnaires, including the Drivers of COVID-19 Vaccination Acceptance Scale; the Risk Perception of the COVID-19 Scale; caregivers’ Difficulties in Asking Their Children to Adopt Self-Protective Behavior Scale; the Brief Symptom Rating Scale; the Parental Bonding Instrument; the Swanson, Nolan, and Pelham version IV Scale; and the questionnaires for the intentions to vaccinate their children and child’s medication use for treating ADHD. The results demonstrated that 82.5% of caregivers reported their willingness to vaccinate their children definitely or under doctors’ recommendation; the level of intentions to vaccinate significantly increased compared with that of caregivers in the first wave of the study. Caregivers’ drivers of COVID-19 vaccination uptake, namely, values, impact, and autonomy but not knowledge; being male caregivers; being caregivers of girls; and the older age of the children were positively associated with caregiverscaregivers’ intentions. The specific intervention programs for enhancing caregivers’ intentions should be specified according to the sex and age of caregivers and of the children with ADHD. The Drivers of COVID-19 Vaccination Uptake should be also the target of intervention for enhancing caregivers’ intentions through strengthening caregivers’ acceptance of the COVID-19 vaccines’ values, positive impact and autonomy to vaccinate their children.
Frequency and Nuisance Level of Adverse Events in Individuals Receiving Homologous and Heterologous COVID-19 Booster Vaccine
Authors: Rzymski Piotr , Sikora Dominika , Zeyland Joanna , Poniedziałek Barbara , Kiedik Dorota , Falfushynska Halina , Fal Andrzej
Published: May 2022

This study aimed to compare the occurrence and nuisance of adverse events following administration of each COVID-19 vaccine dose between two groups: individuals given three doses of mRNA vaccine (homologous group, 3 × mRNA, n = 252) and those given two doses of adenoviral vector vaccine further boosted with mRNA vaccine (heterologous group, 2 × AZ + 1 × mRNA, n = 205). Although the studied groups differed significantly in the frequency and number of side effects after the first and second vaccine dose, no relevant differences were seen following the booster administration. Arm pain and fatigue were the most common effects, regardless of the vaccination group and vaccine dose. In the homologous group, female sex, lower BMI, and no history of regular influenza vaccination were associated with a higher frequency of side effects of a booster dose. In the heterologous group, the history of COVID-19 was associated with an increased number of side effects seen after a booster. In both groups, the number of side effects related to the first and second dose correlated with the number observed after administration of a booster dose. Individuals receiving a homologous booster reported a higher nuisance of side effects than the heterologous group. It was similar to the level reported after the second dose in both groups. The use of pharmaceuticals to counteract the side effects was more frequent after a first dose in the 2 × AZ + 1 × mRNA group, but higher after second dose in individuals receiving the 3 × mRNA vaccination scheme. The frequency of pharmaceutical use after a booster dose was similar in both groups (approx. 60%). Paracetamol was most frequently chosen, regardless of the group and vaccine dose. In addition, the vast majority of participants (93%) declared to accept future doses of the COVID-19 vaccine if their administration would be recommended. This study provides an overview of the response to homologous and heterologous mRNA vaccine booster dose that may be valuable in shaping accurate and honest communication with vaccinated individuals, especially in those regions which are yet to pursue booster strategies.
Breakthrough COVID-19 Infections in the US: Implications for Prolonging the Pandemic
Authors: Alcendor Donald J. , Matthews-Juarez Patricia , Smoot Duane , Hildreth James E. K. , Lamar Kimberly , Tabatabai Mohammad , Wilus Derek , Juarez Paul D.
Published: May 2022

The incidence of COVID-19 breakthrough infections—an infection that occurs after you have been vaccinated—has increased in frequency since the Delta and now Omicron variants of the SARS-CoV-2 coronavirus have become the dominant strains transmitted in the United States (US). Evidence suggests that individuals with breakthrough infections, though rare and expected, may readily transmit COVID-19 to unvaccinated populations, posing a continuing threat to the unvaccinated. Here, we examine factors contributing to breakthrough infections including a poor immune response to the vaccines due to the fact of advanced age and underlying comorbidities, the natural waning of immune protection from the vaccines over time, and viral variants that escape existing immune protection from the vaccines. The rise in breakthrough infections in the US and how they contribute to new infections, specifically among the unvaccinated and individuals with compromised immune systems, will create the need for additional booster vaccinations or development of modified vaccines that directly target current variants circulating among the general population. The need to expedite vaccination among the more than 49.8 million unvaccinated eligible people in the US is critical.
Course of Fecal Calprotectin after mRNA SARS-CoV-2 Vaccination in Patients with Inflammatory Bowel Diseases
Authors: Pokryszka Jagoda , Wagner Angelika , Wiedermann Ursula , Tobudic Selma , Herkner Harald , Winkler Stefan , Brehovsky Sonja , Reinisch Walter , Novacek Gottfried
Published: May 2022

Background: Two years into the pandemic, vaccination remains the most effective option to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Preliminary studies suggest vaccination efficacy in patients with inflammatory bowel diseases (IBD), but little is known about its impact on chronic intestinal inflammation. Here we assessed the mucosal inflammatory activity in patients with IBD before and after immunization with the mRNA-1273 (Moderna) vaccine by measurement of fecal calprotectin (fCP). Methods: In 42 patients with IBD, the baseline fCP levels obtained prior to the first vaccine were compared with the highest levels measured during and after two doses of vaccination. Patients’ sera were collected after the second dose to evaluate anti-SARS-CoV-2 antibodies’ titers. Results: We observed a significant fCP elevation in 31% of patients after any dose. Vedolizumab was identified as the only agent associated with an fCP increase (OR 12.4, 95% CI [1.6; 120.2], p = 0.0171). Gastrointestinal adverse events were reported in 9.5% of all subjects and in 75% of cases accompanied by an fCP increase. Anti-SARS-CoV-2 antibodies associated only weakly with the fCP increase after the first dose (p = 0.04). Conclusions: Our findings support possible collinearity in pathways of SARS-CoV-2 antigen expression and the pathogenesis of IBD.
Effects of Exercise and Physical Activity Levels on Vaccination Efficacy: A Systematic Review and Meta-Analysis
Authors: Dinas Petros C. , Koutedakis Yiannis , Ioannou Leonidas G. , Metsios George , Kitas George D.
Published: May 2022

Objective: We examined whether different intensities of exercise and/or physical activity (PA) levels affected and/or associated with vaccination efficacy. Methods: A systematic review and meta-analysis was conducted and registered with PROSPERO (CRD42021230108). The PubMed, EMBASE, Cochrane Library (trials), SportDiscus, and CINAHL databases were searched up to January 2022. Results: In total, 38 eligible studies were included. Chronic exercise increased influenza antibodies (standardized mean difference (SMD) = 0.49, confidence interval (CI) = 0.25–0.73, Z = 3.95, I2 = 90%, p < 0.01), which was mainly driven by aerobic exercise (SMD = 0.39, CI = 0.19–0.58, Z = 3.96, I2 = 77%, p < 0.01) as opposed to combined (aerobic + resistance; p = 0.07) or other exercise types (i.e., taiji and qigong, unspecified; p > 0.05). PA levels positively affected antibodies in response to influenza vaccination (SMD = 0.18, CI = 0.02–0.34, Z = 2.21, I2 = 76%, p = 0.03), which was mainly driven by high PA levels compared to moderate PA levels (Chi2 = 10.35, I2 = 90.3%, p < 0.01). Physically active individuals developed influenza antibodies in response to vaccination in >4 weeks (SMD = 0.64, CI = 0.30–0.98, Z = 3.72, I2 = 83%, p < 0.01) as opposed to <4 weeks (p > 0.05; Chi2 = 13.40, I2 = 92.5%, p < 0.01) post vaccination. Conclusion: Chronic aerobic exercise or high PA levels increased influenza antibodies in humans more than vaccinated individuals with no participation in exercise/PA. The evidence regarding the effects of exercise/PA levels on antibodies in response to vaccines other than influenza is extremely limited.
Persistent Enterovirus Infection: Little Deletions, Long Infections
Authors: Chapman Nora M.
Published: May 2022

Enteroviruses have now been shown to persist in cell cultures and in vivo by a novel mechanism involving the deletion of varying amounts of the 5′ terminal genomic region termed domain I (also known as the cloverleaf). Molecular clones of coxsackievirus B3 (CVB3) genomes with 5′ terminal deletions (TD) of varying length allow the study of these mutant populations, which are able to replicate in the complete absence of wildtype virus genomes. The study of TD enteroviruses has revealed numerous significant differences from canonical enteroviral biology. The deletions appear and become the dominant population when an enterovirus replicates in quiescent cell populations, but can also occur if one of the cis-acting replication elements of the genome (CRE-2C) is artificially mutated in the element’s stem and loop structures. This review discusses how the TD genomes arise, how they interact with the host, and their effects on host biology.
Potential for a Plant-Made SARS-CoV-2 Neutralizing Monoclonal Antibody as a Synergetic Cocktail Component
Authors: Jugler Collin , Sun Haiyan , Grill Francisca , Kibler Karen , Esqueda Adrian , Lai Huafang , Li Yize , Lake Douglas , Chen Qiang
Published: May 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a public health crisis over the last two years. Monoclonal antibody (mAb)-based therapeutics against the spike (S) protein have been shown to be effective treatments for SARS-CoV-2 infection, especially the original viral strain. However, the current mAbs produced in mammalian cells are expensive and might be unaffordable for many. Furthermore, the emergence of variants of concern demands the development of strategies to prevent mutant escape from mAb treatment. Using a cocktail of mAbs that bind to complementary neutralizing epitopes is one such strategy. In this study, we use Nicotiana benthamiana plants in an effort to expedite the development of efficacious and affordable antibody cocktails against SARS-CoV-2. We show that two mAbs can be highly expressed in plants and are correctly assembled into IgG molecules. Moreover, they retain target epitope recognition and, more importantly, neutralize multiple SARS-CoV-2 variants. We also show that one plant-made mAb has neutralizing synergy with other mAbs that we developed in hybridomas. This is the first report of a plant-made mAb to be assessed as a potential component of a SARS-CoV-2 neutralizing cocktail. This work may offer a strategy for using plants to quickly develop mAb cocktail-based therapeutics against emerging viral diseases with high efficacy and low costs.
Retroperitoneal Metastatic Apocrine Gland Ductal Adenocarcinoma in a Beagle Dog
Authors: Moon Chang-Hwan , Min Hyun-Ah , Lee Hae-Beom , Jeong Seong-Mok , Kim Dae-Hyun
Published: May 2022

Tumors of sweat glands usually originate from apocrine glands and can develop throughout the body but are rare in dogs. This report describes the retroperitoneal metastasis of primary cutaneous apocrine adenocarcinoma. An 8-year-old, spayed female beagle dog, weighing 11.7 kg, presented with a history of anorexia, hypodynamia, and weight loss. Clinical examination, radiography, ultrasonography, and computed tomography revealed a skin mass on the dorsum of the right metatarsal region, an enlarged ipsilateral popliteal lymph node, and a retroperitoneal mass. Fine-needle aspiration cytology of the popliteal lymph node suggested metastasis of an apocrine sweat gland tumor. Surgical excision of the skin mass, popliteal lymph node, and retroperitoneal mass was performed. The retroperitoneal mass was diagnosed as a metastasis of primary cutaneous apocrine adenocarcinoma. Immunohistochemistry revealed that the tumor cells were positive for cytokeratin 7 but negative for cytokeratin 20 and S100 proteins. There were no postoperative complications, except for temporary hindlimb edema, including local recurrence or metastasis, in the 6-month postoperative follow-up period. This case illustrates that although malignant apocrine gland tumors are rare in dogs, a wide resection of primary cutaneous apocrine gland adenocarcinomas is recommended because of the risk of local invasion or distant metastasis.
DETERMINANTS OF FIRM’S PROFITABILITY: IN THE CASE OF SELECTED ETHIOPIAN TANNERY COMPANIES
Authors: Lemma-Lalisho Dereje
Published: May 2022

Purpose: The general objective of this study is to investigate the determinants of profitability in the case of selected Ethiopian Tannery Companies.

Methodology: The study employed an explanatory research design with a quantitative approach to assess the relationship between profitability and its determinant factors. The study had a population size of 29 Tannery Companies in Ethiopia. To undertake this research paper, the researcher used non-probabilistic sampling specifically the judgmental sampling method was used to select eight (8) sample Tannery Companies. Balanced panel data were analyzed by using descriptive statistics, correlation, and Multiple Linear regression analysis. Ordinary Least square model in the form of multiple regression analysis was applied to analyze the annual data generated from the financial statements of the selected Tannery Companies covering a period from 2008 - 2017 G.C. In this study, ROA was used as the measure of profitability.

Findings: The paper includes tangibility, firm size, liquidity, leverage, growth rate, and inventory turnover as independent factors that determine the profitability of Tannery Companies in Ethiopia. The result from the empirical examination found that only Tangibility, Inventory Turnover, and Firm growth rate have a statistically significant effect on the companies (ROA), whereas Liquidity, Leverage, and Firms size have a statistically insignificant effect on the profitability of Ethiopian Tannery Companies.

Conclusion: Besides, the study suggested that companies that give more attention to the statistically significant variables of the sectors such as firm growth rate, inventory turnover, and tangibility. While the results may not be generalizable to all Ethiopian Tannery Companies found in the country, the findings should provide valuable information to managers for developing their strategies with regard to firm-specific determinants.
Konsep Mahar Dalam Perspektif Imam Syafi’i dan Kompilasi Hukum Islam
Authors: Setyowati Rinda
Published: May 2022

Abstract This study is intended to understand more deeply related to the concept of dowry according to Imam Syafi'i and the Compilation of Islamic Law, for this reason this study was carried out using the library method, namely examining the subject matter by examining books and fiqh books that are related to the problems that the researcher is studying. do. From this discussion, it can be concluded that, firstly, the position of the dowry according to Imam Syafi'i is not included in the pillars of marriage. Second, regarding several dowry provisions in marriage, some of Imam Syafi'i's opinions are very influential in the Compilation of Islamic Law, as in Articles 30 31, 32, 33, 34, 35, 36, 37, and 38 except for the issue of adding a dowry. For the payment of the addition of a dowry, his opinion has no effect on the Compilation of Islamic Law which is not mentioned in it, on the grounds that the addition of a dowry only occurred during the time of the previous madhhab scholars. If at this time it can happen because it is motivated by several cultural factors or customary law, not the Marriage Law.AbstrakKajian ini dimaksudkan untuk memahami lebih dalam terkait  konsep mahar menurut Imam Syafi’i dan Kompilasi Hukum Islam, untuk itu kajian ini dilakukan dengan menggunakan metode kepustakaan yaitu meneliti pokok permasalahan dengan mengkaji buku-buku maupun kitab-kitab fiqih yang ada kaitannya dengan permasalahan yang peneliti lakukan. Dari pembahasan ini dapat disimpulkan bahwa, pertama  mengenai  kedudukan  mahar  menurut  Imam Syafi’i  bukan termasuk rukun dalam perkawinan. Kedua, mengenai beberapa ketentuan mahar dalam perkawinan sebagian pendapat Imam Syafi’I sangat berpengaruh dalam Kompilasi Hukum Islam, sebagaimana dalam Pasal 30 31, 32, 33, 34, 35, 36, 37, dan 38 kecuali masalah penambahan mahar. Untuk pembayaran penambahan mahar pendapat beliau tidak berpengaruh dalam Kompilasi Hukum Islam yang tidak disebutkan didalamnya, dengan alasan bahwa penambahan mahar hanya terjadi pada zaman ulama madzhab terdahulu. Seandainya pada zaman sekarang dapat terjadi karena dilatarbelakangi oleh beberapa faktor kebudayaan atau hukum adat bukan Undang-Undang Perkawinan.
Faktor Penyebab Perceraian Warga Binaan Pemasyarakatan (WBP) Perempuan Rutan Jepara dan Upaya Penguatan Ketahanan Keluarga Melalui Konsep Keluarga Sakinah
Authors: Puji Sri Pujiati
Published: May 2022

Having a happy and harmonious home life is certainly a dream for everyone. But in the journey of marriage life is not always smooth and without obstacles. Married life is sometimes tricky and full of sharp pebbles or not always happy. So many have to stop in the middle of the road but many are able to pass to the end.This happened to the inmates at the Jepara Detention Center where out of the fourteen inmates in the Jepara Detention Center, nine of them had experienced divorce or were unable to maintain their married life. The reasons are different.For this reason, it is necessary to have an understanding and knowledge of the concept of a sakinah family that can be used as a guide in carrying out domestic and married life after serving a sentence.The concept of the sakinah family is very relevant because the concept of the sakinah family is in accordance with Islamic teachings and can be applied in an effort to realize family resilience. In order to be able to produce a quality generation and of course useful for the nation and religion.Memiliki kehidupan rumah tangga yang bahagia dan harmonis tentu menjadi dambaan bagi semua orang. Namun dalam perjalannya kehidupan pernikahan tidak selalu mulus dan tanpa hambatan. Kehidupan pernikahan terkadang ebrliku dan penuh dengan kerikil tajam atau tidak selalu bahagia. Sehingga banyak yang harus berhenti di tengah jalan namun banyak juga yang mampu melewati hingga akhir. Hal ini terjadi pada WBP Rutan Jepara di mana dari empat belas jumlah WBP yang ada di Rutan Jepara, sembilan di antaranya pernah mengalami perceraian atau tidak bisa mempertahankan kehidupan pernikahannya. Alasannya pun berbeda-beda. Untuk itu perlu pemahaman dan pengetahuan tentang konsep keluarga sakinah yang bisa dijadikan pedoman dalam menjalankan kehidupan rumah tangga dan pernnikahan setelah menjalani masa hukuman. Konsep keluarga sakinah sangat relevan karena konsep keluarga sakinah ini sesuai dengan ajaran Islam dan bisa diterapkan dalam upaya mewujudkan ketahanan keluarga. Agar mampu menghasilkan generasi yang berkualitas dan tentunya berguna bagi bangsa dan agama.
Implementasi Perma No 1 Tahun 2016 Tentang Mediasi Perkara Perceraian di PA Jepara
Authors: Choeri Imron , Fitriani Rani
Published: May 2022

This study aims for the first, analyzing Perma No. 1 year 2016 on the procedure of conducting mediation whether in accordance with the implementation of mediation in the Jepara Religious Court. Second, the effectiveness of mediation in divorce cases in the Jepara Religious Court. This research uses normative approach, using qualitative research type and using field research method, namely applied research or field research. To obtain the data is used documentation method. The results of this study stated that, first, most of the ones contained in Perma No. 1 of 2016 have been applied in the Jepara Religious Court, but there are some articles that are not in accordance with the latest Perma, for example the parties that must be in good faith at the time of mediation. Second, the effectiveness of mediation in the Jepara Religious Court, especially in divorce cases is very low, even many cases are entered but mediation can not be carried out. This is the need for socialization to the community the importance of carrying out mediation, whereas mediation is the most important process because to suppress the divorce rate in Jepara Regency.
Atratividade Turística em Unidades de Conservação no Mato Grosso do Sul: perspectivas para o desenvolvimento sustentável
Authors: Silva-Melo Marta Regina da , Guedes Neiva Maria Robaldo
Published: May 2022

Unidades de Conservação são territórios importantes para a proteção da biodiversidade, provisão de diversas funções essenciais à vida e bem-estar humano. A presente pesquisa tem como objetivo analisar a atratividade turística das Unidades de Conservação de Proteção Integral na categoria Parques Estaduais de Mato Grosso do Sul. A metodologia foi fundamentada no Índice de Atratividade Turística das Unidades de Conservação Brasileira, adaptada para a realidade do Mato Grosso do Sul. O índice de atratividade verificado denota que independente da rica biodiversidade (86,3%), e diversidade de paisagens (80,4%) existentes nesses Parques, por si só não se caracterizam como atração turística, haja vista que o turismo nessas áreas ainda é módico, influenciado por diferentes fatores, dentre os quais: gestão desintegrada (64,7%), quadro de servidores insuficientes (67,6%), ausência de infraestrutura (65,7%), falta de divulgação (68,6%), entre outros obstáculos. Uma possível solução seria a prestação de serviços por meio de concessão. Todavia, é imprescindível que o órgão gestor realize a fiscalização e monitoramento dos serviços prestados, a fim de evitar a mercantilização dos Parques Estaduais e a apropriação voltada unicamente para um uso público conflitante aos objetivos dessas Unidades de Conservação.
Planejamento de uma trilha interpretativa em um trecho de mata ciliar do rio Piratini, Cerrito (RS)
Authors: Alberton Jocarlos Goulart , Jacobi Ubiratã Soares
Published: May 2022

O ecoturismo é um turismo de natureza de baixo impacto que contribui à manutenção de espécies e habitats. Áreas naturais protegidas, como a Área de Preservação Permanente (APP), torna-se um meio de contato com a natureza de forma sustentável, com fins de conservação e conscientização ambiental. Matas ciliares são APP, e faz-se necessário o conhecimento da importância desse ambiente quanto sua função ambiental, e seu papel no bem-estar da população. A interpretação ambiental é importante para a sensibilização dos visitantes em ambientes naturais e um meio de contato e integração com a natureza. O presente estudo tem por objetivo o planejamento de uma trilha interpretativa em uma APP de mata ciliar. Foi feita a caracterização física da trilha e seu potencial interpretativo analisado pelo método de Índice de Atratividade dos Pontos Interpretativos (IAPI). A trilha é considerada de curta distância, linear, se enquadra na categoria de nível moderado. Foi possível identificar uma grande riqueza de fauna e flora para o local. Foram levantados 15 pontos interpretativos.