bluuebunny/crossref_metadata_2025 huggingface dataset:
Upaya Meningkatkan Kemampuan Gerak Dasar Lompat melalui Modifikasi Permainan pada Materi Senam Ketangkasan pada Siswa Kelas 5c SDN Manukan Kulon Surabaya Semester Genap Tahun Pelajaran 2022/2023
Authors: Tobi Adimas , Priambodo Anung , Prasetya Rindra Putra
Published: May 2023

The purpose of this study was to improve the basic jumping ability of class 5C students at SDN Manukan Kulon. One indication of the lack of maximum PJOK learning can be seen from the results of the skills scores of class 5C students who are still below the Minimum Completeness Criteria, namely 85. This research uses classroom action research carried out in 2 cycles, in which there are main stages of activity, namely planning, implementing, observing and reflection. The population and research sample used 5C class students with a total of 30. The data collection method consisted of ability tests, observation, and documentation. While the research instrument used skill assessment sheets and attitude observation sheets. Analysis of skills assessment data using a collaborative approach to qualitative and quantitative descriptive methods. Based on the results of the study, judging from the scores on the pretest, there were 13 students or 43% had not completed and 17 students or 57% had completed with an average score of 83.1. There was an increase in cycle I, namely 21 students or 71% completed and 9 students or 29% incomplete, with an average score of 85.6. In cycle II, there was an increase of 26 students or 87% complete and 4 students or 13% incomplete, with an average score of 87.8. According to the classical completeness criteria, more than 80% of students complete. In conclusion, by modifying the game on agility gymnastics material can improve the basic jumping ability.
Kinerja Training Kit Mesin Pengisi dan Penutup Botol otomatis Sebagai Media Praktik Programmable Logic Controllers di SMK
Authors: Sukir Sukir , Wicaksono Tangguh
Published: May 2023

This research aims to: (1) develop a prototype of an automatic bottle filling and capping machine training kit as a Programmable Logic Controllers (PLC) practice tool in vocational high schools (SMK), and (2) assess the performance of the automatic bottle filling and capping machine training kit as a PLC practice tool in SMK. This research adopts the research and development methodology in the field of education. The development model used is the ADDIE model by Robert Maribe Branch. The research consists of the following stages: Analyze, Design, Develop, Implement, and Evaluate. The data collection techniques employed in this study are interviews and questionnaires, using interview guides and questionnaires as instruments. The data obtained were analyzed descriptively. The results of the research indicate that: (1) a training kit for an automatic bottle filling and capping machine has been developed, which consists of main components such as the Conveyor Unit, Water Filling Unit, Water Capping Unit, OMRON CP1E N40 PLC Unit, Training Kit Components Unit, and Input/Output Terminal Block. This training kit serves as a PLC practice tool in SMK; and (2) the automatic bottle filling and capping machine training kit exhibits good performance, as demonstrated by the testing of 43 components, all of which functioned properly. The functional testing conducted under Initial Condition, Watertank Condition, Run Cycle Condition, Stop Condition, and Emergency Condition showed that all components (100%) performed well.
Analisis Kemampuan Penalaran Matematis Awal Siswa SMP dalam Memahami Permasalahan Koordinat Kartesius Berbasis RME
Authors: Nuraini Ririn , Nasution Andrea Arifsyah
Published: May 2023

This research was conducted with the aim of describing the initial mathematical reasoning ability level of junior high school students on the topic of Cartesian coordinates. This research uses descriptive qualitative method. The subjects in this study were 38 grade VIII students of SMP IT Al Hijrah Medan. The research instrument used was in the form of four questions worked on by students with a duration of 60 minutes. Data collection techniques in this study are through observation, interviews, and documentation. Documentation plays an important role in this research because it describes how the research process takes place. The research began with the observation stage, and continued with taking tests of students' mathematical reasoning abilities, then the researchers conducted interviews with students regarding student test results. The results showed that the students' initial mathematical reasoning abilities were still at a low level. In this case, the researcher found that students' initial reasoning abilities had not been able to help students in solving problems.
Upaya Guru dalam Menanamkan Sikap Sosial Peserta Didik Kelas VI melalui Pembelajaran Tema 2 (Persatuan dalam Perbedaan)
Authors: Febbrian Hendro , Febrianti Nurul
Published: May 2023

The importance of instilling social attitudes among elementary school students has attracted the attention of researchers. Due to things that deviate from the social attitudes of the participants, such as there are students who come late to school, there are students who throw garbage carelessly, students do not do class pickets, students do not do homework, students cheat when doing school assignments, there are students students who are embarrassed to ask and there are students who are embarrassed to answer questions. This research aims to find out the teacher's efforts in instilling social attitudes in class VI students through learning the second theme, especially Social Studies and Civics lessons. This research was conducted at SD Negeri Cengkareng Timur 01 Pagi. The type of research used is qualitative using descriptive methods. The research subjects consisted of students, class VI teachers, and school principals. Researchers collect data by interviews, observation, and documentation. Interviews were conducted with class VI teachers and school principals. Observations were made to all students, informants by observing learning activities carried out at school. The results showed that not all of the students had good social attitudes. The teacher's efforts in instilling social attitudes in class VI students can be adjusted to the needs of students' social attitudes. There are eight social attitudes of students, namely (1) honest attitude, (2) discipline attitude, (3) responsibility attitude, (4) caring attitude towards the environment, (5) tolerance attitude, (6) mutual cooperation attitude, ( 7) polite attitude, and (8) confident attitude.
Experimental Investigation for TiO2 nanoparticles as a Lubricant-Additive for a Compressor ofWindow Type Air-Conditioner
Authors: Hussen Haider ali
Published: May 2023

The coefficient of performance of a window type Air-Conditioner system can be improved if a reduction in the work of compressor can be achieved by a suitable technique. The present study investigates the effect of dispersing a low concentration of TiO2 nanoparticles in the mineral oil based lubricant, as well as on the overall performance of a window type Air-Conditioner system using R22 as the working fluid. An enhancement in the COP of the refrigeration system has been observed and the existence of an optimum volume fraction noticed, with low concentrations of nanoparticles suspended in the mineral oil. Results showed that the average compressor work reduced by 13.3%, which ultimately resulted in an increase of 11.99% in the COP due to the addition of nanoparticles in the lubricating oil.
Adverse Childhood Experiences Among University Student and The Relationship With Depression
Authors: Rahmatullah Bagas , Nurul Adellia , Hasgat Channia , Putri Ginta Sellia , Tambunan Inggrid Nathania , Mantika Siti Hawa Annisa , Faradiba Andi Tenri
Published: May 2023

In a research conducted by Hillis et al. (2016), worldwide, 1 billion children aged 2-17 years experience ACE in various forms, such as sexual abuse, emotional abuse, and neglect. Traumatic childhood experiences can potentially negatively affect health and well-being in the long term (Sacks, Murphey, and Moore, 2014). This research aims to determine the correlation between exposure to adverse childhood experiences and a tendency to depression. This study uses a quantitative approach with a statistical correlation test. There were 499 participants in this study with the ACE-IQ measuring instrument to measure the type of exposure to violence and the PHQ-9 to measure the level of depression. The statistical analysis showed a significant relationship between ACE and a tendency to depression with r=.43; p < .001. Therefore, based on the statistical analysis results using Pearson Correlation, we concluded a positive correlation between Adverse Childhood Experiences and a tendency to depression. However, this study still does not comprehensively explain the level of ACE exposure and depression regarding gender and age differences.
Bird names as critical communication infrastructure in the contexts of history, language, and culture.
Authors: Winker Kevin
Published: May 2023

Standardized taxonomies and lists of birds were created to improve communication. They are linguistic infrastructure―biodiversity indices and dictionaries―that have been painstakingly built and maintained and that have enhanced regional and global participation in the study and enjoyment of birds. Inclusion of people has been a core objective in creating and maintaining these standardized lists, and dissatisfaction and desires to overwrite objectionable names have been associated with them for nearly two centuries. Suggestions that bird names should be changed are continuous. Today, these suggestions include the view that some bird names must be changed to make them more accurate, inoffensive, and culturally appropriate to further increase diversity and inclusion among ornithologists and bird watchers. The latter, meritorious goal has been largely successful thus far despite many ongoing objections. Historic examples indicate that large-scale name changes, however, are not needed to accomplish major societal goals of inclusion. Some barriers to inclusion likely remain, and some changes are likely needed for English names. Often overlooked or underappreciated in name change discussions are that: 1) standardized names lists have had staggering success in fostering inclusion of diverse participants globally; 2) stability is vital in such systems, and destabilization is exclusionary; 3) dissatisfaction with such lists and the names they include has been ongoing since these naming systems began; 4) important flexibilities exist in conjunction with these communication systems that enhance local and regional communication (e.g., alternative names in English and other languages); and 5) cultural values, important as they are, are neither universally shared nor constant, and thus bring inherent divisiveness and instability when used as a central reason for change. Consideration of standardized lists of bird names as communication systems in the fuller context of history, language, and culture will improve our management of these systems and their continued utility in fostering inclusion. With standardized, stable, naming systems acting as a skeleton, proactively building outwards, both within and among languages and cultures, offers a positive and productive way to increase inclusion and to improve cultural and biodiversity conservation.
Pathways into, desistance from, and risk factors related to cyber-dependent crime: A systematic narrative review
Authors: Loggen Joeri , Moneva Asier , Leukfeldt Eric Rutger
Published: May 2023

Understanding cybercrime involvement is critical to tackle the growing global threat it represents. However, research is heterogeneous and scattered across different disciplines. Following the PRISMA-ScR guidelines, this systematic narrative review synthesizes 86 documents on pathways into, desistance from, and risk factors related to cyber-dependent crime (hacking, malware, and DDoS attacks), and identifies research gaps. Analyses indicate that individuals interested in technology and online videogames meet peers involved in hacking activities, learn from them, and begin to engage in cybercrime. Desistance is influenced by a cost-benefit analysis and maturing. We also identified 27 risk factors for cyber-offending, including being young, male, having low self-control and deviant peers, and frequently using the Internet. Lastly, we outline multiple research gaps.
Revisiting Multi-frequency AC Networks
Authors: Gambirasio Giorgio , Consonni Denise
Published: May 2023

The analysis of RLC networks is broadened to the case where the sinusoidal voltage generators supplying the AC network are of arbitrary, different frequencies, and including some temperature-dependent resistors (called TDRs), therefore introducing some nonlinearity.For the sake of completeness, the linear case is firstly examined, showing how the Principle of Superposition may be systematically used to solve the network, either with algebraic methods or with linear ODE’s.When the network is nonlinear due to the presence of TDRs, the resulting system of differential and algebraic equations must be solved with the help of programs like Python or Mathematica. It is also shown that using the capacitance inverse S=1/C simplifies mathematical expressions.Various numerical examples are presented, with the corresponding graphs of currents, voltages, temperatures and resistances.TDR thermal inertia affects the way a resistor responds to an AC current: at high frequencies, TDRs tend to reach a steady state constant temperature; at low frequencies, they follow the AC, and the temperature (and resistance) oscillates at double the frequency of the current variation.
Global mean sea level higher than present during the Holocene
Authors: Creel Roger , Austermann Jacqueline , Kopp Robert , Khan Nicole , Albrecht Torsten , Kingslake Jonathan
Published: May 2023

Global mean sea-level (GMSL) change can provide insight on how ice sheets, glaciers, and oceans respond to warming[1;2]. The Holocene (11.7 ka to present) marks a time when temperatures may have exceeded early industrial (1850 CE) values[3]. Evidence from Greenland[4] and Antarctica[5;6] indicates that both ice sheets retreated inland of their present-day extents during the Holocene, yet previous GMSL reconstructions suggest that Holocene GMSL never surpassed early industrial levels7–9. We combine relative sea-level observations with glacial isostatic adjustment predictions from an ice-sheet model ensemble and new estimates of postglacial thermosteric sea-level and mountain glacier evolution to estimate Holocene GMSL and ice volume. We show it is likely (probability P =0.79) that GMSL exceeded early industrial levels in the mid-Holocene (8-4 ka) by up to 1.5 m and that the Antarctic Ice Sheet was likely (P =0.66) smaller than present in the last 6000 years. We demonstrate that Antarctic retreat lags Antarctic temperature by 250 years, underscoring future Antarctic vulnerability to present warming. Comparing our reconstruction to future projections indicates that GMSL rise in the next 125 years will very likely (P >0.9) be the fastest in the last 5000 years, and that by 2080 GMSL will more likely than not be the highest in 115,000 years.
Salivary cortisol responses on the Trier Social Stress Test-Online based on smoking habit and resilience score
Authors: Ueno Masaharu
Published: May 2023

Background: In Japan, four items–alcohol, tobacco, coffee and tea–are included in the category of "Shikohin". The meaning was 'something that is not nutritious and yet is consumed for flavor.' In terms of Shikohin, we hypothesized that, similar to our previous study of drinking habits, participants with high resilience scores and high smoking habits would exhibit blunted cortisol responses to the Trier Social Stress Test-Online (TSST-OL). Methods: An online survey including the Fagerström Test for Cigarette Dependence and resilience scales was conducted. Participants were classified into four groups based on the degree of smoking (≤14 or ≥15 cigarettes per day) and the median total score on resilience scales (Low-Resilience Low-Smoking (N = 10), Low-Resilience High-Smoking (N = 9), High-Resilience Low-Smoking (N = 9), and High-Resilience High-Smoking (N = 11)). Participants were asked to complete the TSST-OL, which measures subjective stress and salivary cortisol levels, at eight time points during the experiment.Results: Individuals with blunted cortisol responses appeared in all four groups similarly; thus, our hypothesis was not supported. However, all groups exhibited similarly elevated subjective stress responses. Conclusions: Our results suggest that habitual smokers may not have an elevated cortisol response, even in subjectively stressful situations. The relationship may be independent of the degree of smoking habit and resilience scores.
How Do You Know That You Don't Know?
Authors: Gronau Quentin Frederik , Steyvers Mark , Brown Scott
Published: May 2023

Whenever someone in a team tries to help others, it is crucial that they have some understanding of other team members' goals. In modern teams, this applies equally to human and artificial ("bot") assistants. Understanding when one does not know something is crucial for stopping the execution of inappropriate behavior and, ideally, attempting to learn more appropriate actions. From a statistical point of view, this can be translated to assessing whether none of the hypotheses in a considered set is correct. Here we investigate a novel approach for making this assessment based on monitoring the maximum a posteriori probability (MAP) of a set of candidate hypotheses as new observations arrive. Simulation studies suggest that this is a promising approach, however, we also caution that there may be cases where this is more challenging. The problem we study and the solution we propose is a general one, which applies well beyond human-bot teaming, including for example the scientific process of theory development.
Who benefits from guidance counseling? Lessons from an intersectional perspective on native and immigrant students from low social origins
Authors: Pietrzyk Irena , Jacob Marita , Erdmann Melinda
Published: May 2023

Research on educational inequalities has increasingly focused on interventions to increase enrollment in higher education for students from low social origins. However, students from low social origins may not be homogenous in their need for advice, as natives from low social origins decide less frequently to enter university than their immigrant counterparts in many European countries. Drawing on data from a randomized controlled trial in German schools, we find that, indeed, counseling in particular increases the likelihood of enrollment for native students. We then use the results of our empirical analyses to illustrate how an upscaling across schools would affect migration-specific enrollment rates of students from low social origins at the aggregate level. We discuss the implications of our results for research on migration-related inequalities in enrollment as well as for policy regarding program upscaling
Evaluation of radiation doses delivered to patients during conventional pelvis radiographic imaging in selected Nigerian hospitals
Authors:   Department of Science Laboratory Technology, Osun State College of Technology, Esa – Oke, Nigeria., Lateef Bamidele , Olowookere Christopher. J. ,   Department of Physics, University of Medical Sciences, Ondo, Nigeria., Olatunji Kehinde. O. ,   Department of Science Laboratory Technology, Osun State College of Technology, Esa – Oke, Nigeria., Gbenga Martins ,   Department of Science Laboratory Technology, Osun State College of Technology, Esa – Oke, Nigeria.
Published: May 2023

Diagnostic X-ray procedures remain the largest contributor to the population dose from man-made radiation sources; therefore, there is need for evaluation of the health risks connected with the use of ionizing radiation in X-ray examinations. The aim of this study is to investigate radiation dose in pelvis imaging procedures in some diagnostic centers in Southern part of Nigeria. Entrance Surface Air Kerma (ESAK) was calculated using exposure parameters obtained during examinations. A total of 160 adult patients undergoing pelvis AP radiography in nine (9) hospitals having ten X-ray centers were considered in the study. The mean ESAK calculated ranged from 1.08 to 16.16 mGy for pelvis AP and ranged from 1.15 to 10.06 mGy for pelvis LAT. Wide variations were found in the dose values obtained from various X-ray units even within the same center. The doses estimated in this study were found to be lower, when compared with the NRPB-HPA 2010 review for UK.
Performance of sorghum varieties in moisture stress areas of South Omo Zone
Authors:   Southern Agricultural Research Institute, Crop Science Research Directorate,  Jinka Agricultural Research Center, Jinka, Ethiopia., Yoseph Tekle , Muluneh Mhiretu ,   Southern Agricultural Research Institute, Crop Science Research Directorate,  Jinka Agricultural Research Center, Jinka, Ethiopia.
Published: May 2023

Sorghum [Sorghum bicolour (L.)] is one of the most important cereal crops in Ethiopia. The low productivity of sorghum has been partly attributed to the use of low-yielding varieties and/or landraces. Field experiments involving four improved (ESH-1, Teshale, Dekeba, Melkam) and one local sorghum variety were carried out at Dasenech, Gnygatom, and Hammer woredas in 2019 under irrigation to identify the best performing varieties. The experimental design was a randomized complete block design (RCBD) with three replications. Parameters such as plant height, panicle length, 1000 seed weight, and seed yield were studied. The combined analysis of variance results showed that there were significant variations among the varieties for all the studied parameters. The mean values for plant height ranged from 172.33 cm for the improved variety Melkam to 263.44 cm for the local check. The mean values for panicle length ranged from 23.89 cm for the local check to 33.78 cm for the improved variety ESH-1. The mean values for 1000-seed weight ranged from 31.67 g for the variety Dekeba to 36.00 g for Melkam. The overall mean values for grain yield ranged from 1312.4 kg ha-1 for the local check to 4050.7 kg ha-1 for the improved variety Melkam. The grain yield advantages of 67.60, 64.54, 62.95, and 56.67% were obtained from the improved varieties Melkam, Dekeba, Teshale, and ESH1, respectively over the local check. The effect of varieties on grain yield was significant and therefore; the best performing varieties of sorghum namely Melkam (4050.7 kg ha-1) and Dekeba (3701.4 kg ha-1) are advisable and could be appropriate for sorghum production in the study areas and similar agro-ecologies even though further testing is required to put the recommendation on a strong basis.
Exploratory studies of Anopheles species abundance in five selected communities of Emohua LGA, Rivers State
Authors:   Department of Parasitology and Entomology, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria., Woke Vivian Chinasa , Inyama Petrus Uchenna ,   PMI Vectorlink Project, Abuja, Nigeria., Aribodor Denis N. ,   Department of Parasitology and Entomology, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria., Ebere Nwabueze ,   Department of Applied and Environmental Biology, Rivers State University, Port Harcourt, Nigeria., Omalu Innocent Chukwuemeka James ,   Department of Animal Biology, Federal University of Technology, Minna, Niger State, Nigeria., Eke Samuel Sunday ,   Department of Biology, Air Force Institute of Technology, Kaduna, Kaduna State, Nigeria.
Published: May 2023

Malaria is one of the public health problems facing people in many parts of Nigeria. To effectively implement malaria control program, baseline studies of species abundance and their susceptibility status to insecticides is required. The aim of the study was to carry out baseline studies on malaria vectors, species abundance and susceptibility status of local malaria vectors in five communities in Emohua Local Government Area of Rivers State. Mosquito larvae were collected from different breeding sites, reared in the insectary and identified morphologically. Data collected were analyzed using SAS software and statistics software GraphPad Software. Spearman’s rank correlation coefficient (RHO) was used in comparing Indoor Resting Density (IRD) and Man Biting Rates (MBR). A Total of 1,415 adult indoor mosquitoes were caught comprising of two (2) genera. Of these, 87.21% were Anopheles gambiae s.l. and 12.79% were Culex spp. There was a statistical difference (p<0.0001) in the distribution of Anopheles and Culex mosquitoes caught. The highest percentage of Anopheles mosquitoes were caught at Emohua 26.74%, followed by Rumuji 22.77%, Egbeda 21.96%, Akpabu 17.10% and the least was Elele 11.43%. Examination of their abdominal conditions to determine feeding frequency indicated that the average number of fed mosquitoes ranged from 0.17-15.13 with a peak of 15.13 in the month of September in Elele. There was a significant difference (p<0.0001) in Indoor Resting Density (IRD) and Man Biting Rate (MBR) in the area. This study has contributed to the understanding of the distribution, composition and indoor resting behaviour of mosquito vectors in the study areas.
Toxicity evaluation of the arils of the fruit of Blighia sapida KD Koenig (Sapindaceae) in Wistar rats
Authors:   Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria., Maigida Hoomsuk H. , Uguru Mary O. ,   Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria., Wannang Noel N. ,   Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria.
Published: May 2023

The Methanol extract of the arils of fruits of Blighia sapida was studied for its toxic effects on certain hematological and biochemical indices as well as the histopathological examination of some organs of the Wistar rats. Preliminary phytochemical screening showed that the plant contains bioactive compounds such as alkaloids, flavonoids, polyphenols, cardiac glycosides, cyanogenic glycosides, steroid glycosides, cardenolides, terpenes and tannins. Three different concentrations of the extract were administered to different groups of the rats orally for 28 days in the sub-acute test and 90 days in the case of the Sub-chronic test. The extract showed no mortality even at a dose of 5000mg/kg. Other results obtained showed a significant increase in some hematological indices such as pack cell volume (PCV), hemoglobin (Hb), red blood cell (RBC), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH). Others are mean corpuscular hemoglobin concentration (MCHC), hematocrit (HCT), and lymphocytes (LYMP). However, white blood cells (WBC) and platelets (PLT) showed a significant decrease as the doses administered increased from low to high. There was also, a significant decrease in the levels of certain biochemical indices such as urea, creatinine, total bilirubin, conjugated bilirubin, alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) while the levels potassium (K+), chloride (Cl-), total protein and albumin were significantly increased. The methanol extract of the arils of fruits of Blighia sapida revealed mild distortion of hepatocytes, loose nuclei within the cells, and also complete loss of sinusoid with an increase in dose within the liver.
Evaluation of wound healing potential of Jatropha curcas leaf extracts ointment based on wound infection in Wistar rats model
Authors:   Department of Biological Sciences, Niger State Polytechnic Zungeru P.M.B 001 Nigeria., Mohammed Adamu S. , Enemaduku Abalaka M. ,   Department of Microbiology Federal University of Technology Minna, Niger State, Nigeria., Yahaya Safiya D. ,   Department of Microbiology Federal University of Technology Minna, Niger State, Nigeria., Muhammad Abdullahi ,   Department of Biological Sciences, Niger State Polytechnic Zungeru P.M.B 001 Nigeria., Oyeronke Kolo O. ,   Department of Biological Sciences, Niger State Polytechnic Zungeru P.M.B 001 Nigeria.
Published: May 2023

This research study was conducted to evaluate the wound healing potential of ointment formulated with Jatropha curcas leaf extracts based on wistrar rat model. The therapeutic activities of the plant extracts were determined by topical application of the herbal ointment. Wound healing rate took place on the 16th day of post treatment with 1.0 g of J. curcas ointment formulation and 12th day with 2.0 g of the ointment, was similar compared with standard drug Gentamicin ointment (12 days). The control untreated group (62.3±0.51%) rate of wound closure observed persisted beyond the 19th day of post-wounding. The haematological parameters of the infected rats treated with herbal ointment and the control group untreated were not significant different (p>0.05). Significant increase in white blood cell (WBC) count in untreated group was recorded when compared with the treated group. However, treatment with the formulated ointments significantly increase the elevated WBC count in the treated group. The toxicological parameters in the serum of the rats are useful makers for the assessment of tissue damage. The serum Aspartate Transaminase (AST) and Alanine Transaminase (ALT) activities in the treated and untreated experimental groups were not significantly (p>0.05) different. The phytochemical components found in J. curcas leaves contain some useful potential antimicrobial agents that possess wound healing properties when formulated into a topical ointment for topical application.
Genetic analysis links the diagnosis of carriers of the PKD1 mutation gene that causes polycystic kidney disease
Authors:   Department of Biology and Genetics, Vietnam Military Medical University, Nguyen Thi Viet Ha , Nguyen Van Phong ,   Department of Biology and Genetics, Vietnam Military Medical University, Tran Van Khoa ,   Department of Biology and Genetics, Vietnam Military Medical University, Trieu Tien Sang ,   Department of Biology and Genetics, Vietnam Military Medical University
Published: May 2023

Polycystic kidney disease (PKD) is an inherited disorder characterised by the formation and growth of multiple cysts in the kidney, accompanied by a gradual increase in the size of both kidneys leading to impaired kidney function and renal failure. Autosomal dominant PKD is the most common genetic disorder with an estimated prevalence of 1/500-1/1000 in Western countries [1], caused by mutations in the PKD1 (MIM#601313) and PKD2 (MIM#173910), of which 85% of cases are caused by mutations in the PKD1 gene [2]. Because of the PKD1gene’s enormous size, numerous mutations, and up to 6 structural pseudogenes, which share a high degree of similarity sequences (97.7%) from the 5’UTR to exon 32 [3, 4], the methods for identifying PKD1 mutations are currently restricted and challenging from amplifying the mutant gene area. Therefore, it is essential to create a novel diagnostic technique with high accuracy and broad applicability for various mutation types that may circumvent the shortcomings of the conventional method. Objective: To develop a genetic linkage analysis technique for detecting the person with PKD1 mutation causing PKD. Materials and methods: 11 members were from a family with PKD1 gene mutations causing PKD. Designed PKD1 gene-linked STRs primers and conducted genetic linkage analysis with the family members. After comparing the outcomes of the technique with those of the Touchdown-PCR and ARMS-PCR methods, the complete technique is subsequently given. Results: Successfully developed the genetic linkage analysis technique for detecting the person with PKD1mutation causing PKD.
Evaluating the effect of screening dual HLA-A*31:01 and HLA-B*15:02 alleles by multiplex real-time PCR technique on reducing the risk of Carbamazepine-induced hypersensitivity reactions
Authors:   Key Laboratory of Enzyme and Protein Technology, University of Science, Vietnam National University, Hanoi, Vo Thi Ngoc Hao , Chu Van Son ,   Key Laboratory of Enzyme and Protein Technology, University of Science, Vietnam National University, Hanoi, Nguyen Doan Thuy ,   Neurology and Stroke Department, Tam Anh General Hospital, Nguyen Van Lieu ,   Neurology and Stroke Department, Tam Anh General Hospital,   Department of Neurology, Hanoi Medical University, Nguyen Thi Van Anh ,   Key Laboratory of Enzyme and Protein Technology, University of Science, Vietnam National University, Hanoi
Published: May 2023

HLA-A*31:01 and HLA-B*15:02 are strongly associated with Carbamazepine (CBZ)-induced severe cutaneous adverse reactions (SCARs). As a result, it is recommended to screen these two alleles before CBZ therapy to reduce the risk of drug allergy. In this study, the authors applied the simultaneous screening test for HLA-A*31:01 and HLA-B*15:02 alleles by multiplex real-time PCR Taqman LNA probe with high sensitivity and specificity in 35 patients that were diagnosed with neurological diseases. Among thirteen patients (37.14% of total) who were positive for single or dual HLA-B*15:02and HLA-A*31:01 alleles were prescribed alternatives to CBZ and monitored for adverse events, only one patient had a mild skin adverse reaction after 24 days using Trileptal (Oxcarbazepine) at a dose of 600 mg/day, 12 patients had no symptoms or allergic reactions. The remaining negative patients showed good tolerance to CBZ therapy without any allergy symptoms. Compared to the data of 30 control samples carrying these one or two alleles and 21 patients exhibiting CBZ-induced severe hypersensitivity reactions (OR=28, 95%CI: 3.15-248.78), these results confirm the importance of screening for HLA-A*31:01 and HLA-B*15:02 alleles before using CBZ in neurological diseases treatment to reduce SCAR rates by replacing CBZ with another drug in patients positive for one of these two alleles.
A study on the bud regeneration ability of Cymbidium wenshanense by in vitro culture
Authors:   Hanoi Pedagogical University 2, Pham Phuong Thu ,   Vietnam Academy of Agricultural Sciences (VAAS), Nguyen Thi Tinh ,   Thai Nguyen University of Agriculture and Forestry, Tran Ngoc Hung ,   Fruit and Vegetable Research Institute, VAAS, Ngo Xuan Binh ,   Thai Nguyen University of Agriculture and Forestry
Published: May 2023

The study on the buds regeneration of Cymbidium wenshanenseorchid seedlings cultured in vitro in the conditions of 25oC room temperature, 65% humidity, 2000 lux light intensity, and 16 hours of lighting a day was implemented with the aim of finding out the proper medium, cytokinin growth stimulators (kinetin, TDZ, and BA), and sucrose concentrations on seed regeneration. Results showed that MS medium had a good effect on seed germination (the highest is 90.54%) and cytokinin BA significantly improved the buds regeneration of Cymbidium wenshanense orchid (4.42 buds of 3.63 cm length, and 272.67 mg weight formed from a sample when 1 mg of BA was added). In addition, sucrose supplemented at 5% concentration was considered to be successful (4.47 buds of 3.6 cm length and 315 mg were produced when 5% sucrose was added). This is a result of practical significance in the conservation and development of Cymbidium wenshanenseorchid in north Vietnam.
CRUCIAL ROLE OF HIGHER EDUCATION TEACHERS IN DEVELOPING PROFESSIONAL CONSCIOUSNESS OF FUTURE DOCTORS
Authors: Pavlenkova O.S. , Kaskova L.F. , Amosova L.I. , Ulasevich L.P. , Zelenska V.S.
Published: May 2023

Defining the role of the teacher in ensuring the quality of professional training of students of higher education is important in any field, and especially in medicine. First of all, the teacher of a higher medical school carries an important mission the formation of a new generation of doctors responsible for the preservation of a healthy society and nation, because in modern realities and socio-economic conditions, health is the most important thing. To achieve the goal, literature and publications on similar topics were analyzed. A teacher, who clearly understands his mission, personal responsibility for the knowledge and skills of the student, continuously strives to improve his professional and personal level, will be able to achieve high pedagogical goals. The formation of a future specialist is closely related to his acquisition of theoretical knowledge and practical skills, which are instilled in him by teachers. In our opinion, the choice of a future profession and the level of education largely depend on the teacher's authority, his teaching style, the ability to arouse interest in his subject, and the ability to constantly maintain interest. That is, the teacher must possess the following qualities: dominant (humanity, intelligence, honesty, dignity) and peripheral (friendliness, wisdom, sense of humour). The main features of the pedagogical process are the cooperation of the teacher and students, aimed at achieving a single goal and the inseparability of the processes of learning and education. According to Article 41 of the Law of Ukraine "On Higher Education", the educational process in higher educational institutions is a system of organizational and didactic measures aimed at mastering the appropriate educational-professional (educational-scientific) program and ensuring patriotic, moral, spiritual, aesthetic and physical development of a person. There is no doubt that the higher school should create all the conditions for the training of future specialists, which would provide an opportunity for the formation and formation of their professional consciousness.
IMPACT OF PARTIAL STENOSIS OF TRACHEA ON ANTIOXIDANT SYSTEM IN YOUNG RATS
Authors: Molochek Yu.A. , Savosko S.I. , Utko N.A. , Makarenko O.M.
Published: May 2023

Introduction. Recently, there has been a significant rise in the attention of researchers and clinicians towards the issue of complex hypoxic trauma affecting various organs and body systems. This is particularly important when considering the cells that are most vulnerable to oxygen deprivation, including brain tissue, lungs, certain organs of the gastrointestinal tract, systemic immunity. The significance of this problem becomes even more relevant when examining the impact of hypoxia on the cells of sexually immature mammals and humans, as well as exploring potential treatments for acute hypoxic conditions including laryngomalacia and stridor observed in children under the age of one year. Moreover, there are a number of associated complex and unresolved issues in experimental clinical practice. The aim of the study is to investigate changes in the enzyme activity of the pro-oxidant-antioxidant system of the lung tissue cells and the central nervous system (cerebrocortex) during the experimental modelling of respiratory pathology (by ligating the upper trachea of rats), the features of their recovery and the dynamics of this process after the surgical removal of the tracheal ligature.

Materials and methods. The studies were performed on 37 sexually immature male Wistar rats, aged 2528 days. The test animals were divided into four groups: the first group served as the control (intact) rats, the second group consisted of rats with experimentally induced tracheal stenosis, which were removed from the experiment in 7 days after the operation, the third group consisted of rats with experimentally induced tracheal stenosis who were removed from the experiment in 21 days after the operation, and the fourth group consisted of rats whose tracheal ligature was removed on the 7th day after the operation and then they were removed from the experiment on the 21st day. The following biochemical parameters were studied: malondialdehyde content, activity of catalase, glutathione peroxidase, glutathione reductase, and superoxide dismutase.

Results. The findings obtained demonstrate an increase in malondialdehyde content and antioxidant enzyme activity in the lung and brain tissues of rats on the 7th and 21st days following partial tracheal stenosis. Restoring airway ventilation did not fully normalize these indicators to the control values.

In conclusion, the findings indicate that the impaired pro-oxidant-antioxidant balance in lung and central nervous system cells did not completely restore even two weeks after relieving the compressive effect on the trachea and resolving the hypoxic respiratory system disorders partially. This suggests the necessity to continue therapy with pharmacological antioxidant agents following surgical intervention. However, further research is required to explore this aspect of the problem in depth.
PENGARUH PERENCANAAN PAJAK, BEBAN PAJAK TANGGUHAN DAN STRUKTUR MODAL TERHADAP NILAI PERUSAHAAN PADA PERUSAHAAN SEKTOR PERKEBUNAN YANG TERDAFTAR DI BEI PERIODE 2017-2021
Authors: Vianna Vera , Yusnaini Yusnaini
Published: May 2023

Penelitian ini menganalisis strategi pajak, beban pajak tangguhan, dan struktur modal terhadap nilai perusahaan. Perusahaan Perkebunan BEI periode 2017-2021 dievaluasi. Data observasi dapat dianalisis dengan menggunakan uji asumsi klasik, regresi linier berganda, uji individu, uji simultan, dan uji determinasi. Perencanaan pajak tidak beri dampak nilai perusahaan, tidak seperti beban pajak tangguhan dan struktur modal. Struktur modal, penangguhan pajak, dan strategi pajak lainnya memengaruhi nilai perusahaan. Percobaan menemukan bahwa perencanaan pajak, biaya pajak tangguhan, dan struktur modal menjelaskan 19,7% dari harga saham. Aset Pajak Tangguhan, Kualitas Audit, Kepemilikan Manajerial, dan Kepemilikan Institusional menyumbang 80,3%.
PERAN SIKAP KEPEMIMPINAN PADA KUALITAS KERJA KARYAWAN MELALUI KOMPENSASI KERJA
Authors: Jannati Bq. Risna Amelia , Supriyanto H. Achmad Sani
Published: May 2023

Penelitian yang dilakukan memiliki maksud untuk mendeskripsikan bagaimana peran sikap kepemimpinan (gaya) yang bersinggungan langsung dengan kualitas kerja karyawan, dimana peran tersebut dilandasi dengan adanya kompensasi kerja terhadap karyawan PT. Laris Abadi Indonesia. Metode riset yang ditetapkan oleh peneliti ialah kuantitatif deskriptif atau bisa dikatakan penjelasan makna sebuah pengaruh melalui angka, serta menetapkan 80 karyawan PT. Laris Abadi Indonesia sebagai sampel daripada responden yang dinyatakan sebagai data primer. Teknik pengumpulan data dilakukan dengan penyebaran angket (kuesioner) secara langsung. Adapun variabel yang di teliti ialah sikap kepemimpinan (X1) dan kompensasi kerja (X2) sebagai variabel bebas serta kualitas kerja (Y) sebagai variabel terikat. Output daripada riset kali ini menggambarkan beberapa kesimpulan yang diantaranya sikap kepemimpinan memiliki peran terhadap kualitas kerja secara signifikan melalui metode parsial dan simultan, dan juga kompensasi kerja mengambil peran yang sama secara parsial dan simultan dengan keterangan positif signifikan pada PT Laris Abadi Indonesia.
PENINGKATAN PRODUKTIFITAS KERJA PEGAWAI MELALUI DISIPLIN KERJA, KECERDASAN EMOSIONAL DAN KOMUNIKASI
Authors: Irwan Irwan , Latief Fitriani
Published: May 2023

Penelitian ini bertujuan menguji pengaruh disiplin kerja, kecerdasan emosional dan komunikasi terhadap produktivitas kerja pegawai pada PT Semen Bosowa Maros. Populasi penelitian ini adalah pegawai Human Resources Departement & General Affair di PT. Semen Bosowa Maros yang berjumlah 36 orang. Dalam penentuan responden dilakukan dengan tehnik sampling jenuh (sensus) yaitu tehnik penentuan sampel semua anggota populasi digunakan sebagai sampel, sehingga diperoleh jumlah sampel dalam penelitian ini adalah 36 responden. Tehnik pengumpulan data dalam penelitian ini yaitu menggunakan kuesioner (angket) untuk responden. Adapun tehnik analisis data yang digunakan dalam penelitian ini adalah regresi linier berganda dengan menggunakan SPSS 26.0 for windows. Hasil penelitian menemukan bahwa disiplin kerja, kecerdasan emosional dan komunikasi memiliki pengaruh positif dan signifikan terhadap produktivitas kerja pegawai pada PT Semen Bosowa Maros.
EVALUATING OF ACCOUNTING INFORMATION SYSTEM LITERATURE ON WEB OF SCIENCE (WOS) DATABASE
Authors: Marditaputri Lila Sabrinta , Handriana Tanti
Published: May 2023

Artikel ini bertujuan untuk mengkaji dan menganalisis topik Sistem Informasi Akuntansi (SIA) yang dipublikasikan dalam database Web of Science. Penelitian ini menggunakan metode Bibliometrik melalui Vos Viewer dan Biblioshiny untuk menunjukkan informasi mengenai tren set, frekuensi produksi artikel, frekuensi penulis, dan beberapa informasi lainnya. Hasil penelitian menunjukkan bahwa penelitian SIA yang pertama kali dipublikasikan dalam database Web of Science tercatat sejak 1975 dan mencapai puncaknya di tahun 2011. Namun puncak produksi artikel SIA pada tahun 2011 disebabkan karena adanya simposium yang dilakukan di China. Namun setelah itu produksi artikel SIA terus menurun dan dalam periode 2012-2021 cenderung meningkat. Hasil lainnya menunjukkan bahwa tidak ada peneliti yang fokus memproduksi artikel penelitian SIA secara konsisten, hal ini dibuktikan dengan penulis yang paling banyak mempublikasikan artikel SIA hanya sebanyak 4 artikel. Publikasi yang rendah ini membuktikan bahwa kolaborasi antar peneliti SIA sangat kurang sehingga banyak artikel yang berstatus single author.
PENGARUH AUDIT FEE TERHADAP INTEGRITAS LAPORAN KEUANGAN DENGAN KEPEMILIKAN INSTITUSIONAL SEBAGAI VARIABEL PEMODERASI
Authors: Setyawati Dinie , Koeswayo Poppy Sofia , Puspitasari Evita
Published: May 2023

Riset ini bertujuan buat mengenali pengaruh audit fee pada integritas laporan keuangan serta untuk mengenali moderasi kepemilikan institusional pada pengaruh audit fee dan integritas laporan keuangan. Pada riset ini integritas laporan keuangan diukur dengan akrual diskresioner. Metode deskriptif merupakan metode yang digunakan dalam riset ini. Populasi pada riset ini adalah perusahaan sektor keuangan yang sudah tercatat dalam daftar Bursa Efek Indonesia pada tahun 2017 - 2019. Teknik purposive sampling dengan beberapa standar digunakan untuk menentukan sampel pada riset ini. Model analisis regresi data panel digunakan sebagai teknik analisis data pada riset ini. Hasil dari riset ini menunjukan audit fee berpengaruh signifikan terhadap integritas laporan keuangan sementara kepemilikan institusional tidak dapat memoderasi pengaruh dari audit fee terhadap integritas laporan keuangan.
THE EFFECT OF PERCEIVED VALUE AND EWOM ON LOYALTY IN THE INDUSTRY CONSUMER GOODS BASED ON EQUITY THEORY
Authors: Tasya Athala Insyira , Marsasi Endy Gunanto
Published: May 2023

This study describes the effect of equity theory on perceived value. Equity theory assumes that, generally, a person likes to act with comparability or fairness. The purpose of this research is to understand the perceived value of consumers and the exchange of information carried out by consumers, which can later encourage someone to buy a good or service. The gap in research, namely perceived value, is that previous studies have different results. Based on this explanation, the aim is to see the effect of corporate social responsibility, perceived value, electronic-word-of-mouth, satisfaction, and loyalty on product purchases in the industry consumer goods. In this study, the EWOM variable becomes a novelty. The research object used is the industry consumer goods. The data was distributed using google forms to 276 respondents. Respondents with productive age are 17-64 years old, know social responsibility, and have a domicile in Java. The test utilizes SEM-AMOS 26 and SPSS-26. In using SEM, it wants to provide information to previous researchers. Furthermore, the result is that there is a negative influence on one of the five positive hypotheses. The variable perception of value is rejected, so there is no interest in purchasing consumer goods that cause loyalty.