bluuebunny/crossref_metadata_2025 huggingface dataset:
El rol de las mujeres en los proyectos de intervención de desarrollo local en comunidades rurales: el caso de un programa de agua y saneamiento en la comunidad de El Carrizo, Durango, México, en el periodo 2010-2015
Authors: Amador Sierra Judith , Custodio González Carlos Alejandro , Serrano Flores María Elena , Pérez Verdín Gustavo , Calderón Cisneros Araceli
Published: November 2024

Este estudio examina la participación de mujeres en el programa de desarrollo local “Manejo Integral de Cuencas Hidrográficas” de la alianza WWF-FGRA en El Carrizo, Durango, México. Se evalúa cómo la participación de las mujeres contribuyó al éxito del programa y a la modificación de las estructuras de género en la comunidad. Utilizando una metodología mixta, se realizaron entrevistas semiestructuradas con participantes y líderes; además, se revisaron informes recopilados a lo largo del año 2023. Los resultados mostraron que, aunque inicialmente las mujeres tenían roles de cuidado, comenzaron a gestionar acciones dentro del programa. La migración de hombres a Estados Unidos llevó a que las mujeres asumieran roles tradicionalmente masculinos, lo que presentó desafíos, pero fortaleció el capital de vinculación y la reciprocidad. El estudio concluye que la participación de mujeres en proyectos de desarrollo local es clave para la equidad de género y la sostenibilidad comunitaria, aunque se necesitan esfuerzos adicionales para abordar la doble presencia femenina y la discriminación de género.
Multiparticulate Drug Delivery of Losartan Potassium via Extrusion-Spheronization: Formulation and Dissolution Comparisons
Authors: Yadav Vishal D. , Salunkhe Dipali S. , Lokhande Vasant Y.
Published: November 2024

Background: Losartan potassium, an antihypertensive medication, has high solubility and a short half-life that result in potential adverse effects and rapid drug clearance. Multiparticulate drug delivery systems enhance the drug’s bioavailability, decrease patient-to-patient variability, and optimize drug distribution. Herein, losartan potassium pellets for sustained drug release were developed and characterized.

Methods: The formulation process involved varying the concentrations of Eudragit RSPO (200 mg, 400 mg, or 600 mg) and Eudragit L100 (200 mg, 400 mg, or 600 mg) across nine pellet batches, and adjusting the triethyl citrate concentrations accordingly. The pellets’ bulk density, tapped density, flow properties (Carr’s index, Hausner’s ratio, and angle of repose), drug content, particle size distribution, and in vitro drug release were evaluated. Interactions between losartan potassium and the excipients were analyzed with FTIR and DSC.

Results: FTIR spectra indicated physical interactions without major chemical alterations, whereas DSC thermograms revealed changes in thermal behavior due to excipient interactions. In vitro drug release studies indicated that formulations with higher concentrations of Eudragit RSPO and triethyl citrate achieved controlled, prolonged drug release. The optimized batch (F7) demonstrated balanced characteristics including favorable bulk and tapped density, good flow properties, and a sustained release profile. Varying the polymer and plasticizer concentrations significantly influenced pellet performance, and F7 was found to be the most promising formulation for sustained-release applications.

Conclusion: This study underscores the importance of polymer selection and formulation optimization in developing effective sustained-release drug delivery systems, and has potential implications for enhancing therapeutic outcomes in clinical practice.
ДОПОЛНЕНИЯ К ЧУЖЕРОДНОЙ ФЛОРЕ НОВОСИБИРСКОЙ ОБЛАСТИ
Authors: Е.Ю. ЗЫКОВА , Т.А. ШЕМЕТОВА
Published: November 2024

Сообщается о новых местонахождениях редко встречающихся в Новосибирской области чужеродных видов: Acer tataricum L. subsp. ginnala(Maxim.) Wesm., Amelanchier ovalis Medik., Bromus tectorum L., Cornus alba L. f. argenteo-marginata (Rehd.) Schelle, Corylus heterophylla Fisch. ex Trautv., Hemerocallis fulva (L.) L., Iris × hybrida hort., Lamium galeobdolon (L.) L., Prunus fruticosa Pall., Rubus odoratus L., Schisandra chinensis (Turcz.) Baill., Sisymbrium volgense M. Bieb. ex E. Fourn., Symphytum caucasicum M. Bieb., Tilia cordata Mill., Veronica filiformis Sm., Viola tricolor L. Отмечено расселение 14 видов, инвазионных или потенциально инвазионных на территории Новосибирской области. Большая часть обсуждаемых видов является эргазиофитами - ушедшими из культуры видами.

New localities of alien species rarely found in the Novosibirsk Region are reported: Acer tataricum L. subsp. ginnala (Maxim.) Wesm., Amelanchier ovalis Medik., Bromus tectorum L., Cornus alba L. f. argenteo-marginata (Rehd.) Schelle, Corylus heterophylla Fisch. ex Trautv., Hemerocallis fulva (L.) L., Iris × hybrida hort., Lamium galeobdolon (L.) L., Prunus fruticosa Pall., Rubus odoratus L., Schisandra chinensis (Turcz.) Baill., Sisymbrium volgense M. Bieb. ex E. Fourn., Symphytum caucasicum M. Bieb., Tilia cordata Mill., Veronica filiformis Sm., Viola tricolor L. Dispersal of 14 species, predominantly invasive or potentially invasive, was recorded in the Novosibirsk Region. Most of the discussed species are ergasiophytes - species that have left the culture.
The gut microbiota as a therapeutic target in children with autism spectrum disorder – current literature review
Authors: Grębska Paula , Szeląg Magdalena , Dancewicz Anna , Kofla-Dłubacz Anna , Choroszy-Król Irena , Stawarski Andrzej , Pytrus Tomasz
Published: November 2024

The high prevalence of autism spectrum disorder (ASD), the specificity of paediatric patients and the determination of their parents give rise to the growing interest of scientists in potential therapeutic approaches. There are multiple aetiological factors involved, and more will probably be discovered. Currently, the involvement of genetic and environmental factors in the aetiology is widely accepted. Growing evidence has been presented for the link between gut dysbiosis and autism. Analysing recent scientific reports, attention was drawn to the proportion and composition of gut microbiota in children with this diagnosis. These are mainly Bacteroidetes, Firmicutes and Actinobacteria, all of which were more abundant in children with ASD than in controls. In turn, children with ASD showed significantly higher counts of Bacteroides, Parabacteroides, Clostridium, Faecalibacterium and Phascolarctobacterium and lower percentages of Coprococcus and Bifidobacterium. If the initial hypotheses support microbial involvement in ASD-related symptoms, clinical trials with microbiota as a therapeutic target would be highly desirable. Recently, researchers have also been interested in faecal microbiota transplantation and microbiota transfer therapy. However, given the inconsistency in results between different centres, final conclusions cannot be reached. Differences in the composition of microbiota arise from, among others, the large age range of patients, which has a general impact on the variability of the microbiome composition over the years of life, environmental diversity with its dietary and cultural habits affecting the unique composition of the microflora, as well as food selectivity that is typically seen in ASD.
Hypersensitivity to erythritol in a 7-year-old boy
Authors: Kowalczyk Agnieszka , Tunowska Dominika , Krogulska Aneta , Kuczyńska Renata
Published: November 2024

Hypersensitivity reactions to erythritol are rare, with an incidence of less than 1:1,000,000. In recent years, the widespread use of erythritol has increased significantly, which may result in an increase of the frequency of hypersensitivity reactions. We discuss the clinical features and the diagnostic process in a case of hypersensitivity to erythritol in a seven-year-old boy. The presented patient developed generalised urticaria, vomiting, weakness, and shortness of breath within minutes of eating a homemade cake containing erythritol. A few months later urticaria appeared on the boy’s face and trunk 30 minutes after eating a homemade cake containing maltitol. Skin prick tests and intradermal tests with erythritol were performed, yielding negative results. An oral challenge with erythritol, using increasing doses of 250 mg, 500 mg, and 1,000 mg every 30 minutes, was positive. It was recommended to eliminate sweeteners from the diet. It is important to remember about food additives when searching for the causative agents of anaphylactic reactions.
Atypical changes in the nail apparatus in a patient with atopic dermatitis – a clinical case report
Authors: Jaworek Andrzej Kazimierz , Możdżeń Kamil , Murawska Agnieszka , Jaworek Magdalena , Kroczka Sławomir , Kurzawa Ryszard , Wojas-Pelc Anna
Published: November 2024

Atopic dermatitis is a chronic recurrent skin disease characterised by itching and eczematous skin lesions. The paper presents the case of a 62-year-old female patient suffering from atopic dermatitis, in whom symptoms were observed within the nail apparatus of the hand, including red rings, Beau lines, lack of cuticle and lichenification with erosions, cracks, scabs, and residual blisters on the backs of the hands. The patient experienced severe itching, which led to increased manipulations within the nail apparatus (onychotillomania), which was reflected in the presence of the so-called tare nails. The patient’s treatment included the use of topical medications, including clobetasol propionate, mometasone, and tacrolimus 0.1%, as well as intensive hand lubrication and the use of specialised hand cleansers. Intensification of mental health care was also recommended. The presented case highlights the importance of a comprehensive approach to the treatment of atopic dermatitis, especially in the era of new therapeutic methods.
PENGARUH KELENGKAPAN PRODUK DAN PROMOSI TERHADAP KEPUTUSAN PEMBELIAN (Studi pada Konsumen Toko Bazar Bangunan Tambun Bekasi)
Authors: Muhammad Hamzah Ramazan
Published: November 2024

This study aims to determine the partial and simultaneous effect of Product Completeness and Promotion on Consumer Purchase Decisions at the Toko Bazar Bangunan Tambun Bekasi. The research method used is descriptive and verification research methods with a quantitative approach. Data analysis techniques using Descriptive Analysis, Validity Test, Reliability Test, Multiple Linear Regression Test, t-test (partial), F-test (simultaneous), and Coefficient of Determination Test using SPSS version 27. Based on the results it shows that Product Completeness has an effect positive and significant effect on Purchase Decisions and Promotions have a positive and significant effect on Purchase Decisions and simultaneously Completeness of Products and promotions have a significant effect on Purchase Decisions as evidenced by the value of Fcount > Ftable which is 563.221> 3.10, when referring to the test of the coefficient of determination of 0.924 or 92.4% and 7.6% were influenced by other factors that were not investigated by the researchers. Thus, the relationship between the variables in this study has a very strong level of relationship.
PENGARUH TINGKAT LITERASI DAN INKLUSI KEUANGAN SYARIAH TERHADAP MINAT MENGGUNAKAN PRODUK DAN JASA BANK SYARIAH
Authors: Rossyidah Ni’matu Rossyidah , Haulah Haulah Nakhwatunnisa , Dewi Dewi Fatmasari
Published: November 2024

Salah satu faktor yang mendorong per­kem­bangan bank syariah ialah literasi keuangan syariah dan inklusi keuangan syariah yang dimiliki oleh masyarakat Penelitian ini bertu­juan untuk menginvestigasi pengaruh tingkat literasi keuangan syariah dan inklu­si keuangan syariah terhadap minat menggunakan produk dan jasa bank syariah di Kelurahan Kenanga Kecamatan Sumber Kabupaten Cirebon, dengan meng­gunakan metode penelitian kuantitatif dengan studi lapangan. Data pene­litian yang digunakan dalam penelitian ini menggunakan data primer dan data sekunder. Penelitian ini menggunakan teknik analisis regresi linear berganda melalui bantuan program IBM SPSS Statistic version 23. Hasilnya menun­jukkan bahwa secara parsial maupun simultan literasi keuangan syariah dan inklusi ke­uangan syariah berpengaruh signifikan serta memiliki hubungan positif terhadap minat menggunakan produk dan jasa bank syariah di Kelurahan Kenanga Kecamatan Sumber Kabupaten Cirebon.
The Orientation of Romanesque Marian Churches in Soria (Spain)
Authors: Abril-Hernández José M.
Published: November 2024

This work studies orientations of 150 parish churches with Marian dedications in the province of Soria, Spain, grouped into subsamples according to Romanesque chronology and dedication to the Marian advocation of the Assumption. The hypothesis of observing local sunrise for aligning churches versus solem orientem during a restricted Romanesque working calendar (i.e. excluding winter and harvest-time) is assessed via a large number of simulated probability densities of declinations, allowing for the application of the confidence envelope method. It was found that the hypothesis cannot be discarded for Romanesque churches with Marian dedications other than to the Assumption, alignments to sunrise on specific Marian feast days being absent in these churches. In contrast, the null hypothesis of the working calendar can be discarded for the Romanesque churches dedicated to the Virgin of the Assumption. As shown in previous studies, about 50% of these churches show intended alignments, of which two thirds are toward the sol aequinoctialis and one third to sunrise on the feast day (15 August). This last alignment pattern is a singular feature of the advocation of the Assumption, and its use in Spain cannot be older than the mid-to-late twelfth century. The theological or theoretical foundations for this practice are unknown. The paper shows that the methods used by archaeoastronomy for the quantitative statistical assessment of null hypotheses are powerful tools for inferring alignment patterns of cultural relevance.
Avaliação dos Aspectos Sócio-Econômicos e Ambientais dos Agricultores da Associação dos Produtores Rurais de Corumbataí do Sul - PR
Authors: Franco Janaina de Melo , Lemos Graziele , Araújo José Hilton Bernardino de
Published: November 2024

O município de Corumbataí do Sul localiza-se na região Centro-Oeste do estado do Paraná, e seu Índice de Desenvolvimento Humano é 0,678, sendo um dos menores do estado. É o maior produtor de maracujá, e por meio de uma Associação, comercializa as frutas e produtos dos agricultores. Nesse trabalho foi realizado um levantamento das questões ambientais e sócio-econômicas dos agricultores da Associação de Produtores Rurais de Corumbataí do Sul. Um dos principais objetivos deste trabalho foi conhecer um pouco da realidade vivida por esses agricultores, sendo entrevistados 99 agricultores num universo de 350 associados. Com os dados coletados e tabulados, pode se verificar que 38% dos entrevistados têm uma renda mensal por família de até de R$380,00 com a venda de produtos agrícolas, geralmente café (53%) ou maracujá (34%). O número de pessoas por família residentes nas propriedades rurais é em média de 4 (24%) a 5 pessoas (13%). Residências com mais de 5 pessoas atinge um percentual de 24%. A maioria das propriedades rurais apresenta um tamanho de até 5 alqueires (55%). O lixo doméstico gerado nas propriedades é queimado por 68% dos entrevistados. As embalagens de agrotóxicos geralmente são devolvidas por 76% dos agricultores ao local onde a compraram, no entanto, uma parte dos agricultores ainda queimam as embalagens (6%) e 12% armazenam na propriedade porque não sabem dar uma destinação adequada, mostrando-se preocupados e ao mesmo tempo interessados com as questões ambientais.
Análise dos Impactos da Fumicultura Sobre o Meio Ambiente, á Saúde dos Fumicultores e Iniciativas de Gestão Ambiental na Indústria do Tabaco
Authors: Schoenhals Marlise
Published: November 2024

O Brasil ocupa uma posição de destaque no mercado mundial de folhas de fumo, sendo o segundo maior produtor e maior exportador desta commodity. A fumicultura é integrada ao complexo agro-industrial do fumo, composto basicamente por empresas transnacionais, sendo o vínculo entre produtor e capital estabelecido pelo Sistema Integrado de Produção de Fumo (SIPF). A produção de tabaco requer o uso intensivo de agrotóxi- cos e o uso de pesticidas em larga escala tem provocado danos à saúde dos agricultores e de suas famílias, ao ecossistema com a contaminação dos alimentos, do solo, da fauna, dos rios, além de desmatamento e perda de biodiversidade. Desta forma, o presente trabalho teve como objetivo analisar os impactos da fumicultura sobre o meio ambiente, à saúde e à qualidade de vida dos fumicultores, incluindo aspectos relacionados à uti- lização de agrotóxicos, equipamentos de proteção individual (EPIs), questões de saúde e demais riscos. Para tanto, foi utilizada a metodologia da pesquisa bibliográfica e de campo, envolvendo a última, 10 fumicultores localizados no município de Verê-Pr. Os resultados demonstraram que os pequenos agricultores optaram pela cultura do tabaco em função da lucratividade obtida, a qual não seria alcançada com outras culturas em função da pequena área dos produtores. Apesar dos problemas relatados, os fumicultores em geral, não apresentam um adequado nível de conscientização sobre os perigos a que estão expostos, não associando, algumas vezes, tais problemas ao cultivo do tabaco. Entretanto, com a preservação do meio ambiente e a questão ambiental obtendo maior importância no Brasil, pôde-se constatar que a indústria fumageira também vem promovendo e divulgando algumas iniciativas de gestão ambiental.
Técnicas sociocríticas de investigación acción participativa: herramientas para la transformación y emancipación comunitaria
Authors: Coronado Martínez Ever , Saleme Negrete Yadith
Published: November 2024

El presente artículo elucida y reflexiona los fundamentos filosóficos y epistemológicos del pensamiento y las teorías críticas, inmerso en la I.A.P, y cómo estos principios la sustentan como una metodología orientada a la transformación y emancipación de comunidades, mostrando la superación de las dinámicas hegemónicas en la investigación clásica, abriéndose hacia una visión participativa de quienes dejan de ser sujetos investigados y se convierten en coinvestigadores de sus propias realidades, contribuyendo a una comprensión profunda de las dinámicas sociales y sus movilidades desde los estados de conciencia. Desde una metodología interpretativa, la publicación se fundamenta  en una revisión teórica y reflexiva de las técnicas utilizadas en los procesos de transformación y emancipación de la I.A.P, de esta forma, se desarrolló: 1. Una deconstrucción epistémica de la teoría y pensamiento sociocrítico, su historia, naturaleza e intencionalidad  para identificar los fundamentos epistemológicos y filosóficos de la I.A.P; 2. Análisis reflexivo y caracterización de algunas de las técnicas  para la participación e interpretación de la emancipación; 3. Explicación de la superación  de las contradicciones metodológicas y paradigmática que posibilitan la integración de otras técnicas de recolección de datos, siempre y cuando estas complemente y no deslegitime la interpretaciones subjetivas e intersubjetivas de la participación en las investigaciones sociales. Las conclusiones del artículo destacan cómo la I.A.P ha desarrollado una identidad propia que facilita la participación y transformación de las comunidades, promoviendo la desalienación y una conciencia crítica. Esta metodología, flexible pero rigurosa, permite a los grupos base participar activamente en la reflexión sobre sus necesidades y problemáticas, legitimando tanto el conocimiento popular como el científico. La originalidad del estudio radica en el análisis profundo de la I.A.P como una metodología dialógica y participativa que integra la teoría y la praxis, permitiendo a las comunidades ser coinvestigadoras activas y legitimadoras del conocimiento colectivo, superando las contradicciones de las metodologías tradicionales.
Discursive Patterns of Opinion-Based Knowledge in the Production of Health-Related Social Media Posts in Turkey
Authors: Peschke Lutz , Gümüş Ağca Yasemin , Dündar Irmak
Published: November 2024

Online media platforms play a central role in presenting opinions, facilitating information exchange, and supporting knowledge production. However, on most social media platforms, verifying the credibility of posts and comments remains highly challenging due to their open nature and lack of a strong governance structure. At the beginning of the COVID-19 pandemic, social media platforms became tainted by uncertain knowledge, partly caused by the limited control these platforms have over user-generated content. This lack of credible information fueled a collective state of panic (Peschke, 2021). Since social media spaces largely involve individuals engaging and sharing their opinions, the credibility of knowledge production on these platforms must be questioned. Despite the proliferation of disinformation, uncertainty, and misinformation on social media platforms (Wardle & Derakhshan, 2017), opinion-based knowledge production has also emerged from these channels, which are challenging to monitor. This article analyzes the communication patterns on health of Turkish posts and comments on Facebook and Twitter during October and November 2021. The data were evaluated against opinion-based content, allowing this study to trace the dynamics of posts and comments by categorizing them as opinion, information, or knowledge production. Data interpretation is grounded in these classifications, with particular attention to the interplay between public engagement and health information. Understanding how the media-based public creates opinion-based knowledge during the uncertainty of the COVID-19 pandemic underscores the potential for collaboration between media-based publics and scientific authorities.
GUÍA THE DIDACTIC KEMISTRY BASADA EN EL MÉTODO KAIZEN Y EN LA METODOLOGÍA AGILE LEARNING
Authors: Urquizo Cruz Elena Patricia , Oñate Leal Kevin Sebastián , Sánchez Salcán Narcisa de Jesús , Orrego Riofrío Monserrat Catalina
Published: November 2024

Para el aprendizaje de las reacciones químicas deben implementarse nuevas metodologías que fomenten en el estudiante el análisis, reflexión y aplicación del conocimiento científico para la resolución de problemas. El objetivo de la presente investigación fue implementar la guía The Didactic Kemistry, una propuesta educativa basada en el método Kaizen y en la metodología Agile Learning, con el fin de mejorar el aprendizaje de las reacciones químicas en los estudiantes. Esta investigación tuvo un enfoque cuantitativo que responde al paradigma positivista y diseño cuasi-experimental. La población estuvo conformada por 29 estudiantes del período académico 2024-1S de la asignatura de Química Inorgánica, considerado el grupo experimental y 31 estudiantes del período 2023-2S, considerado como grupo de control, ambos de la carrera de Pedagogía de las Ciencias Experimentales: Química y Biología de la Universidad Nacional de Chimborazo. Los resultados demuestran que la combinación del método Kaizen y la metodología Agile Learning facilita el aprendizaje de las reacciones químicas de manera dinámica, y evidencian su efectividad en la mejora del rendimiento académico del grupo experimental.
Spectral Properties of the "Reaction-Diffusion" System Operators and Bifurcations Signs
Authors:   UFА University of Science and Technology, Yumagulov Marat G. , Vasenina Natalia A. ,   UFА University of Science and Technology
Published: November 2024

The article discusses differential equations that arise when modeling reaction-diffusion systems. Questions about the stability of equilibrium points in critical cases, as well as about bifurcations in the vicinity of such points, are studied. The main attention is paid to the linearized problem operators spectral properties study. The spectrum discreteness was established, the root properties and invariant subspaces were studied, and formulas for eigenfunctions were proposed. As an application, questions about the multiple equilibrium bifurcation signs and Andronov–Hopf bifurcation in the vicinity of equilibrium points are discussed. Examples are given to illustrate the proposed approaches effectiveness in studying stability and bifurcations problems.
The Gyrostat Motion Around the Inertia Center in the Semi-Euclidean Space
Authors: Makeev Nikolay N.
Published: November 2024

The inertial motion of a gyrostat in a semi-Euclidean space with given index and defect is studied. A gyrostat with a constant gyrostatic moment moves so that its carrier rotates around a fixed center of inertia. Criteria for the existence of regular motions are obtained as a condition for the presence of axial structural-kinetic symmetry of the gyrostat. The properties of nutational, precessional, vibrational-rotational motions are studied and their description in configuration and phase spaces is given. The quadrature dependences of the gyrostat motion parameters in elliptic functions of time are determined. Parametric equations of hodographs of angular velocity and kinetic momentum vectors are found. The study was carried out for the case of the gyrostat angular momentum eigenvector.
A Net Virus Spreading in a Local Computer Network Modeling With Using Percolation Theory Methods
Authors:   Perm State University, Buzmakova Mariya M. , Vorobiev Egor A. ,   Perm State University
Published: November 2024

A net virus spreading in a local computer network is investigated in this paper. Two percolation models were proposed to describe two types of networks: wired and wireless. The percolation threshold corresponds to the fraction of infected computers in the network at which the network loses its operability. Algorithms for lattice filling by occupied nodes, for distributing occupied nodes into clusters, for searching a percolation cluster and for the percolation threshold determining were developed and implemented for the models. A numerical experiment was conducted to estimate the percolation threshold and its dependence on various virus characteristics.
To the study of ixodid ticks of the Bolshesosnovsky municipal district of the Perm Krai
Authors:   Perm State University, Efimik Viktor E. , Telegina Aleksandra A. ,   Perm State University
Published: November 2024

This article presents the results of studying the abundance, biotopic location and seasonal dynamics of ixodid ticks Dermacentor reticulatus Fabricius, 1794 and Ixodes persulcatus (Schulze, 1930) on the territory of the Bolshesosnovsky municipal District located in the south-west of Perm Krai. An analysis of the biotopic abundance of ticks showed that I. persulcatus prefers various types of forests (relative abundance per season ranged from 20 to 104 specimens/flago-km), and D. reticulatus prefers meadow stations (relative abundance per season ranged from 39 to 830 specimens/flago-km). Assessment of the influence of temperature and humidity on tick activity has shown that for each factor in all biotopes and for each species there is a moderate or noticeable correlation of environmental parameters with changes in tick activity. The analysis of the seasonal dynamics of the activity of the studied species revealed the following: in May or early June, on average, there is a high number of adult ticks of both species, in midsummer their activity drops to zero and only in D. reticulatus activity resumes in late summer and early autumn and becomes even higher than in spring.
Intermicrobial interactions in bacterial-fungal associations
Authors:   Tyumen State Medical University, Nikolenko Marina V. , Sivkova Darya S. ,   Tyumen State Medical University, Baryshnikova Natalya V. ,   Tyumen State Medical University, Sorogina Lidiya V. ,   Tyumen State Medical University
Published: November 2024

One of the factors contributing to the increase in the incidence of mycoses is the formation of intermicrobial associations with opportunistic microbiota. Changing the balance in such communities may cause the emergence of other associated diseases. The influence of microorganisms on each other occurs through signaling molecules and exometabolites. Complex bacterial and fungal associations of pathogens of purulent-inflammatory infections are more difficult to respond to antimicrobial therapy and lead to a more severe clinical course or death. This review examines the features of bacterial-fungal interactions of Candida sрp., Aspergillus spp., Cryptococcus spр. According to literature, the decisive role in the virulent activity of fungi in bacterial-fungal associations is played by the species composition of associates involved in the development of the pathological process. In addition, it is necessary to take into account the quantitative ratio of microorganisms, as well as the degree of virulence of fungi, which increases significantly under the influence of metabolites of associated bacteria. Therefore, further study of fungal-bacterial associations is necessary to understand fundamental issues related to the evolution of microbial virulence and antimicrobial resistance. The interactions in the studied bacterial-fungal associations are very dynamic and diverse. The nature of the relationships between microorganisms affects not only survival, but also the virulence of each other.
MicroRNA expression profiles in blood leukocytes as autism spectrum disorder severity markers in children
Authors:   Chelyabinsk State University, Alekseeva Anna S. , Filippova Yuliya Yu. ,   Chelyabinsk State University, Burmistrova Aleksandra L. ,   Chelyabinsk State University
Published: November 2024

Autism spectrum disorders are a heterogeneous group of neurodevelopmental disorders with unknown etiology. Immune dysfunction may be involved in the etiology and pathogenesis of autism. One of the regulators of interactions between the nervous and immune systems are microRNAs, which can be considered as key players in pathogenesis and diagnostic biomarkers. The present study is devoted to a search for the relationship between leukocyte expression of microRNAs: microRNA-155, microRNA-146a, microRNA-124, microRNA-21 and microRNA-9, and the concentration of cytokines in the blood plasma of autistic children, which was carried out to detect biological markers of the disease and its severity. It was found that in children with mild autism, the expression levels of the studied microRNAs in blood leukocytes did not differ from similar values in children with normotypical development. In leukocytes of children with severe autism spectrum disorders, the expression of microRNA-124 and microRNA-146a is reduced compared to normotypical children, and microRNA-146a is reduced compared to children with mild autism. Two significant positive correlations between microRNA-9/IFNg and microRNA-124/TNFa against the background of a negative interaction between microRNA-155 and TNFa were identified in the group of children with mild autism. Four significant negative relationships between microRNA-9/IFNg; microRNA-146a/IFNg; miR-146a/IL-6 and miR-155/IL-10 were found in children with severe autism spectrum disorders. The expression level of microRNA-146a in leukocytes less than 0.0035 с.u. with 86.7% sensitivity and 89.6% specificity may indicate severe autism in children. Thus, we have identified disturbances in the expression levels of important negative regulators of inflammation and participants in neuro-immune interactions – microRNA-146a and microRNA-124.
Spark plasma sintering of transparent thick magnesium aluminate spinel ceramics
Authors:   Tomsk Polytechnic University, Dvilis Edgar S. , Khasanov Oleg L. ,   Tomsk Polytechnic University, Deulina Daria E. ,   Tomsk Polytechnic University, Stepanov Sergei A. ,   Tomsk Polytechnic University, Shevchenko Ivan N. ,   Tomsk Polytechnic University, Huang Fuli ,   Tomsk Polytechnic University, Valiev Damir T. ,   Tomsk Polytechnic University, Tolkachev Oleg S. ,   Tomsk Polytechnic University, Ilela Alfa E. ,   Tomsk Polytechnic University, Paygin Vladimir D. ,   Tomsk Polytechnic University
Published: November 2024

Magnesium aluminate spinel is a promising material for optical application. It can be used as transparent armor, spacecraft windows, scanners, optical elements in night vision systems, as well as a base (matrix) for scintillation and laser materials. The wide range of practical applications of MgAl2O4 ceramics is due to the complex of its unique properties. The research is aimed to creating transparent ceramic materials with an increased shape factor, relevant and of high practical importance. In the presented work, a comprehensive characterization of the commercial nanopowder of magnesium aluminate spinel is completed. Its main structural features are defined. Rheological properties of nanopowder in the process of its compression and thermal consolidation are investigated on the basis of the provisions of the mechanistic pressing model by approximating experimental data of compaction during spark plasma sintering with a dimensionless logarithmic equation, the graphical representation of which allows us to evaluate the possibility of achieving a non-porous state of the consolidated material and optimize the modes of spark plasma sintering. Shown, that the structure of the sealing surface and the search for the optimal way to increase pressure and temperature during spark pulse plasma sintering on this surface can be used to optimize the consolidation modes of transparent ceramics. Verified discrete element modeling of the processes of packing and consolidation of particles of magnesium aluminate spinel nanopowder has been performed. Model and field experiments have shown that the revealed combination of temperature (1300 °C) and static pressure (100 MPa) is sufficient to obtain a porous ceramic structure and does not lead to excessive recrystallization. It is shown that transparent ceramics based on magnesium aluminate spinel with an increased shape factor can be produced by spark plasma sintering at temperature of 1300 °C and static pressure of 100 MPa. The optical and mechanical properties of the manufactured transparent ceramics are comparable to their analogues. The light transmission of samples reaches 41% of the visible spectrum and 64% in the infrared spectrum, the Vickers microhardness value is 15.6±0.5 GPa, crack resistance is 4.4±0.4 MPa·m1/2, compressive strength is 1.37±0.23 GPa, Poisson's ratio is 0.26±0.01, Young's modulus - 278±6 GPa, shear modulus - 110±2 GPa.
Study of the chemical composition and antibacterial activity of CO2 extracts of Juniperus pseudosabina, Larix dahurica, Taxus cuspidate
Authors:   Tomsk State University, Shapovalova Elena G. , Selikhova Natalia Yu. ,   Tomsk State University, Fedorishin Dmitriy A. ,   Tomsk State University, Kazantseva Ksenia I. ,   Tomsk State University, Khrebtova Daria V. ,   Tomsk State University, Sidelnikov Vladimir S. ,   Tomsk State University, Kurzina Irina A. ,   Tomsk State University
Published: November 2024

Extracts of coniferous plants Juniperus pseudosabina, Larix dahurica, Taxus cuspidata were obtained by supercritical fluid extraction method. In the present study, it was found that polyphenols: isoflavonoids and flavonoids, and especially flavonoglycosides, which have P-vitamin activity, constitute the most extensive group of substances in the CO2 extracts of all three plants. The CO2 extract of Taxus cuspidata can be considered as a promising alternative to Taxus berry in the role of a source for the production of individual taxanes, such as paclitaxel and docetaxel. The presence of such groups of compounds as flavanoids, isoflavanoids in the composition of CO2 extracts increases their potential as sources of biologically active compounds suitable for use as components of biologically active and feed additives with immunomodeling antioxidant properties.
The relationship between the fundamental physical constants and the parameters of the D. I. Mendeleev table
Authors:   Tomsk State University of Architecture and Civil Engineering, Sarkisov Yury S.
Published: November 2024

The periodic system of elements of D.I. Mendeleev reflects not only the chemical classification of atoms, but also stores the codes of nature that have not yet been solved. It is known that at different levels of the organization of the structure of the Universe, all processes can be described using so-called world constants, such as the speed of light, Planck's constant, elementary charge, etc. A special place among them is occupied by a fine structure constant, a dimensionless quantity that unites many world constants. The author suggested that there should be a connection between the fundamental physical constants and the parameters of the D.I. Mendeleev table. This article is devoted to identifying such patterns.
The Effect of Convenience, Attractiveness, and Motivation on the Effectiveness of Online and Offline BIPA Learning Based on Teacher Perceptions
Authors: Defina  , Wahpiyudin Cep Abdul Baasith , Hartati Yulia Sri , Wicaksono Andri
Published: November 2024

Teachers must create an engaging, convenient, and motivating learning environment to ensure the effectiveness of both online and offline BIPA learning. This research aims to identify the characteristics of BIPA (Indonesian Language for Foreign Speakers) teachers and analyze the differences in the levels of effectiveness, attractiveness, motivation, and convenience experienced by teachers during offline and online learning. Furthermore, this research examines the impact of Convenience (ease of access and flexibility), Attractiveness (appeal of content and methods), and Motivation (strategies to inspire engagement) on the overall Effectiveness of BIPA learning based on teacher perceptions. The study finds that Convenience, Attractiveness, and Motivation significantly influence the overall Effectiveness of both online and offline BIPA learning. Additionally, this study seeks to identify strategies teachers employ to foster interest and motivation among BIPA students in both learning modes. This study employs a cross-sectional research design with 100 BIPA teachers as respondents. Data were analyzed using descriptive statistics and partial least squares structural equation modeling (PLS-SEM). The findings indicate that BIPA teachers are generally Indonesian citizens with less than one year of online teaching experience. The study reveals that the attractiveness, convenience, and effectiveness levels are higher offline than online learning. Moreover, attractiveness has a significant positive effect on effectiveness. Field trips are vital activities that generate interest and motivation in offline learning, while simple materials and applications are pivotal in online learning. This research highlights the positive aspects and activities undertaken by BIPA teachers to enhance the effectiveness of online and offline learning.
Conceptual Metaphor BUSINESS IS A JOURNEY in Business Terminology
Authors: Nguyen Hanh T. T.
Published: November 2024

Departing from the conventional understanding that metaphor is merely a component of rhetorical and poetic expression, the Theory of Conceptual Metaphor provides linguistic evidence that metaphor plays a crucial role in creating new specialized vocabulary. The present study attempts to apply the Conceptual Metaphor Theory to analyze the metaphor BUSINESS IS A JOURNEY in nominating business terminology. The corpus of the study comprises 179 metaphorical business terms collected from business dictionaries and textbooks. It is discovered in the study that certain attributes of the “journey” source domain are mapped onto those of the “business” target domain, resulting in four derivative metaphors in business terms, namely companies are conventionally viewed as travelers, business tools are metaphorically described as vehicles, business growth is conceptually viewed as the roadmap and distance covered, and business challenges are metaphorically described as obstacles encountered. The research findings highlight metaphorization as an effective method of business term nomination.
An Eco-Translatological Study of the English Version of Xi Jinping: The Governance of China IV
Authors: Ran Haitao , Huang Siying
Published: November 2024

With the rapid development of China’s foreign relations, the effective dissemination of external publicity texts through high-quality translations has become a pivotal task in enhancing communication between China and the world. Xi Jinping: The Governance of China IV compiles President Xi Jinping’s speeches, talks, addresses, instructions, and congratulatory letters during his presidency, offering significant insights into Chinese political culture. This paper employs Eco-translatology to identify representative cases from the book and analyze the application of translation principles, strategies, and techniques in translating Chinese political texts. Specifically, the study examines translators’ adaptation and selection practices. It investigates the three-dimensional transformations of language, culture, and communication within the English rendition of Xi Jinping: The Governance of China IV.
Implicit Meanings in the Quran: A Pragmatic Perspective
Authors: Zakaria Muhamad Zaidi , Khairuddin Muhammad Nujaid , Isa Abdul Azim Mohamad , Majid Muhammad Arsyad Abdul , Suparia Fariz Azzuan Amat , Raffi Muhammad Syaffiq Mohammed
Published: November 2024

This study investigates the interpretation of indirect speech in the Quran, where meanings often extend beyond what is explicitly stated. Misinterpretations can arise when the listener’s understanding differs from the speaker’s intended meaning, a challenge particularly evident in the Quran due to its complex rhetorical nature. Using Thomas’s (1995) Speaker’s Meaning Framework, the research conducts a document analysis from a pragmatic perspective, focusing on the oral discourse between Prophets and their people. The findings, supported by insights from reputable Quranic scholars, highlight that the speaker’s meaning in indirect speech is best understood by considering both context (including physical, environmental, social, cultural, and linguistic factors) and the speaker’s intention. The study concludes that interpretation methods can be divided into those based on context and intention, and those based solely on intention. These insights are significant for guiding readers of the Quran in accurately interpreting indirect speech.
The Dynamics of Using Euphemisms Related to Sexual Activity in Indonesian Online Social Media
Authors: Darwis Muhammad , Kamsinah  , Fatimah Ainun , Susanti Susi , Nurahmad Muhammad , Imran Muhammad Ali , Iman Muhammad Nur
Published: November 2024

This paper aims to explore the dynamics of using euphemisms related to sexual activity in Indonesian online social media reporting from 2022 to 2024. The unit of analysis consists of sentences containing expressions referring to sexual activity bersetubuh ‘intercourse’. The results show that reporting on topics related to sexual activity in Indonesian online social media is dominated by the use of dysphemism rather than euphemism. In this context, the dysphemistic style is realized through five linguistic mechanisms, resulting in 48 (56.4%) patterns or variations of expressions. The euphemistic style is realized through four linguistic mechanisms, resulting in 32 (27.2%) patterns or variations of expressions. Meanwhile, the orthophemistic style is realized through two linguistic mechanisms, resulting in 5 (5.8%) patterns or variations of expressions. This indicates that the drive for politeness in reporting taboo sexual topics is outweighed by the urge to show a highly critical attitude towards unlawful sexual acts, in addition to sensational motives. The orthophemistic style is also used to reveal the actual (unambiguous) events.
The Contemporary Novel in the Context of Interdisciplinarity, With Specific Reference to DeLillo’s Zero K and McCarthy’s The Road
Authors: Alkashash Abeer A. , Majdoubeh Ahmad Y. , Taleb Hala A. Abu
Published: November 2024

The interdisciplinary approach greatly enriches contemporary novels, allowing researchers to explore complex issues from a multiplicity of angles and perspectives. Communication and collaboration across different disciplines within novels, which some refer to as “consilience,” have had a noticeable impact on these novels’ literary elements and overall narrative. This paper will examine the impact of the interdisciplinary approach on themes, plot, and characterization on two selected contemporary novels: Zero K (2016) by Don DeLillo and The Road (2006) by Cormac McCarthy. It aims to provide a new reading of the two novels from an interdisciplinary perspective, demonstrating how a multidisciplinary approach reveals more meanings and aspects that cannot be revealed as effectively when examined from the viewpoint of a stand-alone discipline.
Mediating the Sugar Baby Imaginary: Popular Narratives About Gender and Sexuality in Sugar Dating
Authors: Sawey Megan
Published: November 2024

The internet is rife with opportunities to participate in dating practices, discourses about gender, romance, and sexuality, and, increasingly, efforts to restrict sexual expression. Therefore, it is important to square popular discourse with the perspectives and thought processes that color women’s participation in romantic and sexual phenomena. This article explores how media narratives about women who pursue relationships at the intersection of intimacy, social class, and labor map onto the realities of their lived experiences. Specifically, I compare an analysis of popular press articles about sugar dating—a mutually beneficial relationship practice wherein people engage in frank negotiations of companionship, intimacy, and material benefits—with interviews with 13 women who have participated in sugar dating. I sought to understand how these women defined sugar dating, what motivated them to sugar date, and where their sugar relationships felt most rewarding or difficult. I argue that, for women, sugar dating can be a site of both labor and leisure. These interviews complicate how contemporary press coverage tends to frame sugar dating, revealing important insights about how women may conform to but also challenge popular narratives about their identities, labor, sexual desires, and agency. My findings, therefore, constitute a narrative about sugar dating that captures the nuances of women’s thinking and operating logics. This is a crucial step forward in elevating the voices of those who participate in sugar dating and other romantic and sexual practices.
DEEP LEARNING-BASED CLASSIFICATION OF SEISMIC EVENTS USING WAVEFORM DATA
Authors: Vasti Manka , Dev Amita
Published: November 2024

Artificial Intelligence (AI)-enhanced seismology has evolved to its tremendous capability in analyzing real-time seismic data. This supports various tasks such as earthquake detection, phase detection, epicentral location prediction, time prediction of future earthquakes, phase picking, first motion polarity, early warning systems etc. This is crucial for the management of emergency hazard response spectra and post-disaster activities.