bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeting the Gatekeeper: Osimertinib in EGFR T790M Mutation–Positive Non–Small Cell Lung Cancer
Authors: Skoulidis Ferdinandos , Papadimitrakopoulou Vassiliki A.
Published: November 2016

In 2015, the FDA approved an unprecedented number of new therapies for non–small cell lung cancer (NSCLC), among them therapies addressing specific genomic tumor subsets in the setting of development of resistance to first-line targeted therapy. Osimertinib (Tagrisso, formerly AZD9291; AstraZeneca) is indicated for patients with metastatic EGFR T790M mutation–positive NSCLC, as detected by an FDA-approved test, who have progressed on or after EGFR tyrosine kinase inhibitor therapy. It received breakthrough therapy designation, priority review status, and accelerated approval from the FDA. Clin Cancer Res; 23(3); 618–22. ©2016 AACR.
A Phase I/II Multicenter Study of Single-Agent Foretinib as First-Line Therapy in Patients with Advanced Hepatocellular Carcinoma
Authors: Yau Thomas C.C. , Lencioni Riccardo , Sukeepaisarnjaroen Wattana , Chao Yee , Yen Chia-Jui , Lausoontornsiri Wirote , Chen Pei-Jer , Sanpajit Theeranun , Camp Aaron , Cox Donna S. , Gagnon Robert C. , Liu Yuan , Raffensperger Kristen E. , Kulkarni Diptee A. , Kallender Howard , Ottesen Lone Harild , Poon Ronnie T.P. , Bottaro Donald P.
Published: November 2016

Purpose: This phase I/II single-arm study evaluated the safety, pharmacokinetics, pharmacodynamics, and activity of foretinib, an oral multikinase inhibitor of MET, ROS, RON, AXL, TIE-2, and VEGFR2, in the first-line setting in advanced hepatocellular carcinoma patients.

Experimental Design: In the phase I part, advanced hepatocellular carcinoma patients were dose escalated on foretinib (30–60 mg) every day using the standard 3+3 design. Once the maximum tolerated dose (MTD) was determined, an additional 32 patients were dosed at the MTD in the phase II expansion cohort for assessment of efficacy and safety. Exploratory analyses were conducted to assess potential biomarkers that might correlate with clinical efficacy and survival.

Results: The MTD of foretinib was established as 30 mg every day. The most frequent adverse events were hypertension, decreased appetite, ascites, and pyrexia. When dosed at 30 mg every day in the first-line setting, foretinib demonstrated promising antitumor activity. According to the modified mRECIST, the objective response rate was 22.9%, the disease stabilization rate 82.9%, and the median duration of response 7.6 months. The median time to progression was 4.2 months and the median overall survival (OS) was 15.7 months. Fifteen candidate biomarkers whose levels in the circulation were significantly altered in response to foretinib treatment were elucidated. Multivariate analyses identified IL6 and IL8 as independent predictors of OS.

Conclusions: Foretinib demonstrated promising antitumor activity and good tolerability in the first-line setting in Asian advanced hepatocellular carcinoma patients. Baseline plasma levels of IL6 or IL8 might predict the response to foretinib. Clin Cancer Res; 23(10); 2405–13. ©2016 AACR.
Injection of hTERT-Transduced Endothelial Progenitor Cells Promotes Beneficial Aortic Changes in a High-Fat Dietary Model of Early Atherosclerosis
Authors: Li Xingsheng , Deng Yanru , Zhao Shunrong , Zhang Dandan , Chen Qingwei
Published: November 2016

Objectives: Cultured endothelial progenitor cells (EPCs) display troubling issues that adversely affect their applicability to endothelial regeneration. We hypothesized that transduction of the human telomerase catalytic subunit (hTERT) gene would enhance EPC function in treating dietary-induced early atherosclerosis (AS). Methods: A dietary-induced early AS model was successfully constructed in 90 healthy male rats, while 30 healthy control (HC) rats were normally fed. Four experimental groups were constructed: an untreated HC group; an untreated AS group injected with PBS; a null EPC AS group injected with null vector-transduced EPCs, and an hTERT EPC AS group injected with hTERT-transduced EPCs. Two months postinjection, abdominal aortas were extracted to validate EPC integration and comparatively assess mRNA and protein expression of the early atherosclerotic markers VCAM-1, ICAM-1, LFA-1, Mac-1, CD44, MCP-1, endothelial nitric oxide synthase (eNOS), and apolipoprotein E. Results: In vitro, hTERT transduction of EPCs resulted in a significantly superior proliferative capacity as well as significantly higher NO, iNOS, and LDH secretory capacity. In vivo injection of hTERT-transduced EPCs produced significant reductions in CD44 and MCP-1 expression as well as a significant increase in eNOS expression relative to injection with null vector-transduced EPCs (all p < 0.05). Conclusion: hTERT-transduced human EPCs may be useful in treating dietary-induced early AS.
Oxidized Low-Density Lipoprotein-Induced Cyclophilin A Secretion Requires ROCK-Dependent Diphosphorylation of Myosin Light Chain
Authors: Su Zizhuo , Lin Rongjie , Chen Yuyang , Shu Xiaorong , Zhang Haifeng , Liang Shumin , Nie Ruqiong , Wang Jingfeng , Xie Shuanglun
Published: November 2016

Objective: Accumulation of cyclophilin A (CyPA) within atherosclerotic lesions is thought to be implicated in the progression of atherosclerosis. However, the source of CyPA within atherosclerotic lesions is still unknown. The aim of this study is to determine the role of oxidized low-density lipoproteins (ox-LDL) in vascular smooth muscle cell (VSMC)-derived CyPA secretion and the underlying mechanism. Methods and Results: Abundant CyPA and α-smooth muscle actin (α-SMA) expressed in atherosclerotic lesions was observed in apolipoprotein E-deficient mice. ox-LDL induced CyPA secretion from a primary culture of rat aortic smooth muscle cells in a dose- and time-dependent manner. Sulfosuccinimidyloleate, a CD36 inhibitor, prevented the ox-LDL-induced CyPA secretion. Pre-exposure to either the actin-depolymerizing agent cytochalasin D or the actin-polymerizing agent jasplakinolide inhibited CyPA secretion induced by ox-LDL. Gene silencing of vesicle-associated membrane protein 2 suppressed ox-LDL-induced CyPA secretion. ox-LDL caused the phosphorylation of myosin light chain (MLC). Inhibition of MLC by blebbistatin reversed the secretion of CyPA and the phosphorylation of MLC induced by ox-LDL. MLC kinase inhibitor ML-7 reduced the monophosphorylation of MLC but did not reduce CyPA secretion. Pretreatment with the rho-associated coiled-coil kinase (ROCK) inhibitor Y27632 blocked diphosphorylation of MLC and secretion of CyPA induced by ox-LDL. Conclusions: ox-LDL-induced CyPA secretion requires vesicle transportation, actin remodeling and ROCK-dependent diphosphorylation of MLC. VSMC-derived CyPA induced by ox-LDL may be associated with increased CyPA expression in atherosclerotic lesions.
A Case Report Demonstrating the Potential Clinical Relevance of Liquid Tumor Biopsies in Lung Cancer
Authors: Suppiah Revathi , Gershenhorn Bruce , Markman Maurie
Published: November 2016

A 50-year-old male with advanced non-small-cell lung cancer was unable to have standard-of-care molecular testing performed at diagnosis as a result of inadequacy of the available tissue. A subsequently performed commercial liquid tumor biopsy (Foundation ACT®) revealed an epidermal growth factor receptor exon 19 deletion, but due to the progression of the tumor and rapid deterioration in the patient’s performance status, a meaningful attempt at therapy directed to this recognized therapeutic target was not possible. This case provides important support for the relevance of liquid tumor biopsies in documenting highly clinically relevant molecular targets, particularly in the setting where limited solid tumor tissue is available for analysis.
Optic Disc Pyogenic Granuloma
Authors: Marback Eduardo F. , Espinheira Fonseca Jr. Luciano , Marback Roberto L.
Published: November 2016

Aim: The aim of this paper was to report a rare presentation of adenoid cystic carcinoma. Method: This is a case report presenting clinical, radiographic, and histopathologic findings. Results: A 72-year-old female with no reported ocular symptoms was found to have an incidental right orbital mass on imaging. Additional studies revealed multiple liver lesions, which were biopsied and found to be consistent with adenoid cystic carcinoma. She was then referred to the ophthalmology service, where ocular examination demonstrated 2.5 mm of right proptosis with elevation and abduction deficits. Diplopia could be elicited in extreme upgaze and right lateral gaze. An excisional biopsy of the orbital mass was performed, with histopathology confirming the diagnosis of primary adenoid cystic carcinoma of the lacrimal gland, thereby also supporting the initial suspicion that the hepatic adenoid cystic carcinoma lesions represented metastases. Conclusion: The authors describe a rare presentation of adenoid cystic carcinoma of the lacrimal gland, initially asymptomatic, with metastatic lesions restricted to the liver at the time of diagnosis. Three previous cases of adenoid cystic carcinoma with isolated metastatic hepatic lesions at the time of diagnosis have been reported; all of these cases localized the primary tumor to the salivary glands.
Assessment of Patient Knowledge of Longitudinal Melanonychia: A Survey Study of Patients in Outpatient Clinics
Authors: Halteh Pierre , Scher Richard , Artis Amanda , Lipner Shari
Published: November 2016

Importance: Subungual melanoma (SM) is a rare subtype of cutaneous melanoma but carries a worse prognosis than similarly staged cutaneous melanomas. Assessing patient knowledge of melanonychia is integral to early diagnosis of SM. Objectives: The aim of this paper is to determine patient knowledge of longitudinal melanonychia (LM) and warning signs for SM, frequency of nail self-examinations, and satisfaction of patients with their physician's nail examinations. Design, Setting, and Participants: We conducted a survey-based study of 363 random patients at Weill Cornell Medicine in New York, USA, performed at 3 different clinics: a general dermatology clinic (n = 167), a nail specialty clinic (n = 44), and a primary care clinic (n = 152). Main Outcomes and Measures: Knowledge of the ABCDEF mnemonic for SM was compared to the ABCD mnemonic for cutaneous melanoma. Analyses were performed for patient behavior regarding suspicious nail changes as well as satisfaction with nail counseling and examination. Results: Only 5% (18/363) of the patients in our study had heard of the ABCDEF mnemonic. In contrast, 9.9% (36/363) of the patients had heard of the ABCD mnemonic for cutaneous melanoma. In total, 37/363 (10.2%) patients reported having LM, 32.4% (12/37) of the patients noted changes in color or width of the band, and 10.8% (4/37) presented with pain or bleeding of the nail, with only 45.9% (17/37) seeking medical attention. Only 11.8% (43/363) of the patients stated that their physician asked them about nail changes, and 1.4% (5/363) of the patients stated that they were counseled about the ABCDEF mnemonic. In comparison, 13.8% (50/363) of the patients were advised on the ABCD mnemonic for the cutaneous melanoma mnemonic. While 70.2% (255/363) of the patients stated that they used sunscreen or wore sun-protective clothing, only 31.4% (114/363) assessed their nails for color changes, with 54.9% (128/233) of the patients categorizing themselves as “very unsatisfied” with the evaluation of their nails by their dermatologist. Conclusions and Relevance: Our data shows that there is a lack of patient knowledge of LM and warning signs for SM. Further testing is needed to determine whether educating patients about LM, warning signs for SM, and nail self-examinations would improve patient outcomes.
The Value of Frontal Planar QRS-T Angle in Patients without Angiographically Apparent Atherosclerosis
Authors: Gungor Mutlu , Celik Murat , Yalcinkaya Emre , Polat Alper Tolga , Yuksel Uygar Cagdas , Yildirim Erkan , Firtina Serdar , Bugan Baris , Ozer Ali Can
Published: November 2016

Objective: The present study was undertaken to investigate the prognostic value of the frontal planar QRS-T angle in patients without angiographically apparent coronary atherosclerosis. Subjects and Methods: Three hundred and seven patients with normal coronary arteries on coronary angiography were included. The absolute difference between the frontal QRS- and T-wave axes was defined as the frontal planar QRS-T angle, and patients were divided into 3 subgroups based on the frontal planar QRS-T angle (<45, 45-90, and >90°). Demographic, clinical, laboratory, and angiographic data were compared between groups. Based on the regression analysis results, patients were recategorized into 4 groups according to their luminal calibers of left main coronary artery (LMCA) and history of hypertension (HT) (nonhypertensive LMCA ≤4.13 mm, nonhypertensive LMCA >4.13 mm, hypertensive LMCA ≤4.13 mm, and hypertensive LMCA >4.13 mm). Results: The median value of the frontal planar QRS-T angle of all participants was 38°. Subjects with the widest frontal planar QRS-T angle were older (p = 0.027), were hypertensive (p = 0.001), and had higher corrected QT values (p = 0.001). Patients with the widest frontal planar QRS-T angle had larger LMCA and left anterior descending coronary artery diameters compared to subjects with a normal and borderline frontal QRS-T angle (p = 0.004 and p = 0.028, respectively). Corrected QT, HT, and LMCA diameter were found as independent predictors of the frontal planar QRS-T angle. Subjects with HT and a larger luminal caliber of LMCA had the widest frontal planar QRS-T angle. Conclusion: Patients with a history of HT and a larger luminal caliber of LMCA had the widest frontal planar QRS-T angle. Since HT-induced electrophysiological changes are still not well established and we observed that changes in the luminal caliber of coronary arteries are associated with an abnormal frontal QRS-T angle, the frontal QRS-T angle could serve as a marker of ventricular repolarization heterogeneity in hypertensive patients in addition to keeping track of arrhythmic events, even before overt disease.
Genetic Lineages of Methicillin-Resistant Staphylococcus aureus Acquired during Admission to an Intensive Care Unit of a General Hospital
Authors: Alfouzan Wadha , Dhar Rita , Udo Edet
Published: November 2016

Objectives: The objectives of this study were to determine the frequency of methicillin-resistant Staphylococcus aureus (MRSA) colonization or infection while on admission to the intensive care unit (ICU), and examine the genetic backgrounds of the MRSA isolates to establish transmission among the patients. Subjects and Methods: This study involved screening 2,429 patients admitted to the ICU of Farwania Hospital from January 2005 to October 2007 for MRSA colonization or infection. The MRSA isolates acquired after admission were investigated using a combination of molecular typing techniques to determine their genetic backgrounds. Results: Of 2,429 patients screened, 25 (1.0%) acquired MRSA after admission to the ICU. Of the 25 MRSA, 19 (76%) isolates belonged to health care-associated (HA-MRSA) clones: ST239-III (n = 17, 68%) and ST22-IV (n = 2, 8%). The remaining 6 MRSA isolates belonged to community-associated clones: ST80-IV (n = 3, 12%), ST97-IV (n = 2, 8%), and ST5-IV (n = 1, 4%). The ST239-III-MRSA clone was associated with infection as well as colonization, and was isolated from patients from 2005 to 2007. Conclusions: The HA-MRSA clone ST239-III persistently colonized patients admitted to the ICU, indicating the possibility of its transmission among the patients over time.
Морфологічні основи розвитку хронічного інтерстиційного сіалоаденіту при патології гепатобіліарної системи
Authors: Levkiv M. O.
Published: November 2016

Reactive changes of different nature in salivary glands is accompanied by many diseases of internal organs. Due to the complex neurohormonal regulation, bile secretion system is functionally interconnected with all organs and systems of the digestive tract. The article presents data of structural changes of acinar tissue and bloodstream of parotid salivary gland in experimental obstructive jaundice. It was established that the degree of morphological changes in the parotid gland, angioarchitectonics state and nature of degenerative and destructive processes is directly dependent on the duration of obstructive cholestasis.
Особливості імунного статусу в осіб із захворюваннями пародонта у поєднанні з гіпотиреозом
Authors: Chorniy A. V.
Published: November 2016

The article presents the results of studies of immune status in patients with hypothyroidism combined with periodontal disease. According to the results demonstrated that in people with periodontal disease on the background of hypothyroidism decrease overall immune resistance.
Атрофія альвеолярного відростка верхньої щелепи після пластики гострих післяекстракційних ороантральних сполучень трапецієподібним клаптем
Authors: Sorokivskyi I. S. , Маshkovа K. O. , Hot I. M.
Published: November 2016

This article describes the changes in height, width and cross-sectional area of the alveolar process of the upper jaw after the closure of acute postextraction oroantral communications by mobilizing mucoperiosteal trapezoidal vestibular flap. Evaluation of these parameters was performed by measuring on computer tomograms taken on the day of surgery and after six months. It was established that horizontal alveolar ridge atrophy significantly exceeds changes in the vertical direction, and the most pronounced difference observed when comparing the cross-sectional area of the alveolar process in the perioperative and control periods. The obtained results exceed known from the literature parameters of the alveolar process atrophy after tooth extractions not accompanied by the maxillary sinus perforation.
ПСИХОТРОПНІ ВЛАСТИВОСТІ ПОТЕНЦІЙНОГО АНТИКОНВУЛЬСАНТА 1-(4-МЕТОКСИФЕНІЛ)-5-{2-[4-(4-МЕТОКСИФЕНІЛ)ПІПЕРАЗИН-1-ІЛ]-2-ОКСОЕТИЛ}- 1,5-ДИГІДРО-4H-ПІРАЗОЛО[3,4-D]ПІРИДИН-4-ОНУ
Authors: Shtrygol' S. Yu. , Kavraiskyi D. P. , Shtrygol' D. V.
Published: November 2016

Вивчено психотропні властивості та взаємодію з речовинами пригнічувального типу нового похідного піримідину - 1-(4-метоксифеніл)-5-{2-[4-(4-метокси-феніл)піперазин-1-іл]-2-оксоетил}-1,5-дигідро-4Н-піразоло [3,4- D]піридин-4-ону в дозі 200 мг/кг, який в попередніх дослідженнях виявив протисудомну дію на рівні вальпроату натрію (300 мг/кг). Встановлено, що сполука чинить виразну седативну дію, виявляє антиамнестичні властивості та слабкий анксіолітичний ефект. Крім того, досліджувана сполука не впливає на депресивну поведінку, не чинить негативного впливу на тонус скелетних м'язів та координацію рухів, а також не потенціює депримуючий вплив етанолу.
ЕКСПЕРТНА ОЦІНКА ЛІКАРСЬКИХ ЗАСОБІВ ГРУПИ S01E «ПРОТИГЛАУКОМНІ ПРЕПАРАТИ ТА МІОТИКИ»
Authors: Kryvoviaz O. V.
Published: November 2016

Проведено анкетування 280 лікарів-спеціалістів (офтальмологів та лікарів загальної практики - сімейної медицини) з метою експертної оцінки препаратів групи S01E «Протиглаукомні препарати та міотики». Розраховано сумарні та середні оцінкові характеристики кожного з досліджуваних препаратів за показниками ефективності, наявності побічної дії, фактичної вірогідності призначення препарату на сьогодні, перспективності застосування препарату, наявності в аптечній мережі. Згідно з отриманими даними здійснено ранжування протиглаукомних препаратів на групи високої, середньої та низької доцільності включення у формулярні та страхові переліки
ДО 80-РІЧЧЯ ВИДАТНОГО ВЧЕНОГО, ПЕДАГОГА ТА ГРОМАДСЬКОГО ДІЯЧА
Authors: Medical University I. Horbachevsky Ternopil State
Published: November 2016

Наукові дослідження професора Чекмана І.С. присвячені питанням загальної, клінічної і радіаційної фармакології, фармакології серцево-судинних лікарських засобів і метаболічних препаратів, біохі­мічної, фізико-хімічної і квантово-хімічної фармакології, токсиколо­гії, фітотерапії.
ДОСВІД ЗАСТОСУВАННЯ ХОЛЕКАЛЬЦИФЕРОЛУ В ЛІКУВАННІ АЛЕРГІЧНОГО РИНІТУ В ДІТЕЙ.
Authors: Selska Z. V.
Published: November 2016

Метою даного дослідження було оцінити ефективність застосування препарату вітаміну D3 в комплексній терапії алергічного риніту (АР) у дітей. Під нашим спостереженням перебувало 34 дитини із сезонним та цілорічним алергічним ринітом, у сироватці крові яких визначали рівень 25(ОН)D за різних режимів дозування холекальциферолу. Вихідний рівень 25(ОН)D у сироватці крові дітей з АР становив 26,91 нг/мл (Me=26,91; Q1=18,23; Q3=28,91), після застосування препарату вітаміну D3 в дозі 2000 щодня протягом 2 місяців – 37,56 нг/мл (Me=37,56; Q1=27,78; Q3=42,35), після літньої пори (без приймання холекальциферолу) – 38,12 нг/ л (Me=38,12; Q1=34,26; Q3=44,79) та після призначення підвищених доз холекальциферолу (4000 МО щодня під час ремісії захворювання та 5000 МО щодня під час загострення хвороби курсом 2 місяці) – 48,35 нг/мл (Me=48,35; Q1=43,67; Q3=62,78). Дітям з алергічним ринітом після застосування підвищених доз препарату вітаміну D3 було рекомендовано приймання холекальциферолу цілорічно, крім літніх місяців, у підтримуючій дозі – 1000 МО щодня, а при загостренні захворювання рекомендовано підвищувати добову дозу до 2000 МО щодня. Хворі під нашим спостереженням перебували протягом 1–1,5 року. При проведенні оцінки клінічного перебігу алергічного риніту в дітей відмічалось полегшення перебігу захворювання, що вказує на доцільність застосування холекальциферолу в дітей з АР цілорічно, крім літніх місяців.
ОЦІНКА ЯКОСТІ ЖИТТЯ У ЖІНОК ІЗ ФІБРОМІОМОЮ МАТКИ ДО ТА ПІСЛЯ ОПЕРАТИВНОГО ЛІКУВАННЯ.
Authors: Boychuk A. V. , Formaziuk T. V. , Koblosh N. D.
Published: November 2016

Досвід показує, що у жінок з міомою матки підвищений рівень тривожності, а це може призвести до зниження активності і якості життя, а в подальшому до соціальної та особистої ізоляції в період оперативного лікування. У зв’язку з цим оцінка якості життя пацієнток в наш час набуває все більшого значення поряд з основними традиційними методиками оцінки ефективності лікування та наслідків захворюваності. За отриманими результатами, якість життя у жінок репродуктивного та пострепродуктивного віку, які перенесли оперативне лікування з приводу міоми матки, на основі запропонованої нами терапії покращилася.
ОПТИМІЗАЦІЯ ВИБОРУ МЕТОДУ ЕНДОСКОПІЧНОЇ ОПЕРАЦІЇ У ПАЦІЄНТІВ З НЕПЛІДДЯМ , ОБУМОВЛЕНИМ СИНДРОМОМ ПОЛІКІСТОЗНИХ ЯЄЧНИКІВ.
Authors: Hromova A. M. , Nesterenko L. A. , Tarasenko K. V. , Martynenko V. B. , Krutikova E. I.
Published: November 2016

У роботі представлені результати відновлення репродуктивної функції у жінок з ендокринною формою безпліддя, обумовленого синдромом полікістозних яєчників, шляхом оптимізації методу ендоскопічного хірургічного лікування. Рівень репродуктивних гормонів у групі жінок до оперативного лікування характеризувався достовірним підвищенням у 2,4 раза вмісту загального тестостерону (р<0,001). Гормональний профіль жінок із СПКЯ відзначається дисбалансом репродуктивних гормонів з підвищеною продукцією андрогенів, які призводять до формування кістозної атрезії фолікулів з гіперплазією тека клітин, строми і ущільнення білкової оболонки яєчників. Порівняння двох методів оперативного втручання показало перевагу декапсуляції 1/3 яєчників, як найбільш обґрунтованої патогенетично, що сприяє відновленню двофазного циклу, овуляції і реалізації репродуктивної функції пацієнток.
ГОРМОНАЛЬНИЙ ФОН ХВОРИХ З ВЕЛИКИМИ ЕНДОМЕТРІОЇДНИМИ КІСТАМИ ЯЄЧНИКІВ.
Authors: Kurylo O. Yu.
Published: November 2016

Було обстежено 74 хворих з одно- та двобічними ендометріоїдними кістами яєчників. Виявлено суттєву різницю в рівні СА-125, АМГ, кількості антральних фолікулів та об’ємі здорової тканини яєчників у жінок з одно- та двобічними ендометріоїдними кістами, що свідчило про негативний вплив захворювання на стан оваріального резерву хворої жінки та рівень гіпофізарно-гіпоталамічної регуляції репродуктивної функції.
МАРКЕРИ РОЗПАДУ КОЛАГЕНУ В РОЗВИТКУ ПРОЛАПСУ ГЕНІТАЛІЙ У ЖІНОК В ПЕРИМЕНОПАУЗІ.
Authors: Shcherbyna M. O. , Lamia Alaiia
Published: November 2016

Одним із поширених захворювань у жінок перименопаузального віку є пролапс геніталій, асоційований з дисплазією сполучної тканини. З метою вивчення патогенетичного значення маркерів розпаду колагену у розвитку пролапсу геніталій у жінок в перименопаузі обстежено 90 пацієнток з генітальним пролапсом та ознаками ДСТ і 30 жінок у перименопаузі без пролапсу геніталій і фенотипових ознак дисплазії сполучної тканини. У пацієнток з пролапсом геніталій в поєднанні з ДСТ відзначалися порушення колагеноутворення, порушення в системі матриксних металопротеїназ, обміну глікозаміногліканів і мінерального обміну. Корекція обмінних процесів дозволить профілактизувати подальше прогресування захворювання.
Особливості лікування мультифокальної високодиференційованої тиреоїдної карциноми
Authors: Kobrynska N. Ya.
Published: November 2016

Здійснено порівняльний аналіз моно- та мультифокальних високодиференційованих тиреоїдних карцином. Всього проаналізовано 2211 випадків монофокальних та 693 випадки монофокальних уражень. У результаті проведеного аналізу встановлено, що у хворих на мультифокальну карциному порівняно з хворими на монофокальну карциному операційне лікування частіше проводили в 1999–2008 рр., у них частіше застосовували тиреоїдектомію з дисекцією і значно рідше – інші операції, у тому числі й кінцеву тиреоїдектомію, у цих пацієнтів частіше здійснювали повторні операції, відмічали частіше трикратне і більше  застосування радіойоду, серед них реєстрували більше невилікуваних хворих, за ними здійснювали триваліше спостереження після операції.
Діагностично-лікувальний алгоритм у попередженні післяопераційної тромбоемболії легеневої артерії
Authors: Venher I. K. , Kostiv S. Ya. , Zarudna O. I. , Budnik D. Yu.
Published: November 2016

Моніторинг стану венозної системи нижньої порожнистої вени проводять з 2-ї доби післяопераційного періоду, повторюючи його на 4-ту, 6-ту, 8-му доби. Залежно від отриманих результатів ультрасонографічного обстеження вен басейну нижньої порожнистої вени визначається подальша обґрунтована лікувальна тактика, що дозволяє запобігти розвитку тромбоемболії легеневої артерії.
Міні-інвазивні способи лікування пахвинних гриж
Authors: Krestianov M. Yu.
Published: November 2016

Вибір малоінвазивного підходу до лікування пахвинних гриж на сьогодні залишається спірним питанням. Дві найпоширеніші техніки – лапароскопічна трансабдомінальна преперитонеальна пластика (TAPP) та тотальна екстраперитонеальна пластика (TEP), при яких сітчастий імплант встановлюється в преперитонеальний простір для повного перекриття слабких місць пахвинної ділянки, не відрізняються за рівнем рецидивів, але мають певні відмінності за тривалістю операції, кривою навчання, рівнем інтра- та післяопераційних ускладнень, вартістю втручання. Порівняння вищеназваних технік дає можливість визначити оптимальну тактику з урахуванням індивідуальних особливостей конкретного пацієнта.
Increased Notch3 Activity Mediates Pathological Changes in Structure of Cerebral Arteries
Authors: Baron-Menguy Celine , Domenga-Denier Valérie , Ghezali Lamia , Faraci Frank M. , Joutel Anne
Published: November 2016

CADASIL (Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy), the most frequent genetic cause of stroke and vascular dementia, is caused by highly stereotyped mutations in the NOTCH3 receptor, which is predominantly expressed in vascular smooth muscle. The well-established

TgNotch3
R169C

mouse model develops characteristic features of the human disease, with deposition of NOTCH3 and other proteins, including TIMP3 (tissue inhibitor of metalloproteinase 3), on brain vessels, as well as reduced maximal dilation, and attenuated myogenic tone of cerebral arteries, but without elevated blood pressure. Increased TIMP3 levels were recently shown to be a major determinant of altered myogenic tone. In this study, we investigated the contribution of TIMP3 and Notch3 signaling to the impairment of maximal vasodilator capacity caused by the archetypal R169C mutation. Maximally dilated cerebral arteries in

TgNotch3
R169C

mice exhibited a decrease in lumen diameter over a range of physiological pressures that occurred before myogenic tone deficits. This defect was not prevented by genetic reduction of TIMP3 in

TgNotch3
R169C

mice and was not observed in mice overexpressing TIMP3. Knock-in mice with the R169C mutation (

Notch3
R170C/R170C

) exhibited similar reductions in arterial lumen, and both

TgNotch3
R169C

and

Notch3
R170C/R170C

mice showed increased cerebral artery expression of Notch3 target genes. Reduced maximal vasodilation was prevented by conditional reduction of Notch activity in smooth muscle of

TgNotch3
R169C

mice and mimicked by conditional activation of Notch3 in smooth muscle, an effect that was blood pressure–independent. We conclude that increased Notch3 activity mediates reduction in maximal dilator capacity of cerebral arteries in CADASIL and may contribute to reductions in cerebral blood flow.
Returning the Look
Authors: Barnbrook Gioia
Published: November 2016

It has been argued that a contemporary penchant for wildlife images serves to cloak the various destructive impacts human actions have on nonhuman animals, as well as to distract us from our ever-decreasing direct encounters with them. However, this form of media has also demonstrated its effectiveness as a method for communicating conservation messages to the wider public. This paper seeks to examine this tension through an analysis of a famous reunion clip from the documentary Christian the Lion (1971), exploring how audiences have reacted to this clip through a selection of YouTube comments and asking what these comments can tell us about contemporary ideas relating to human/animal inter-subjectivity.
The Earliest Reference to Israel and Its Possible Archaeological and Historical Background
Authors: Zwickel Wolfgang , van der Veen Pieter
Published: November 2016

Manfred Görg proposed to read the name Israel on a broken Egyptian inscriptionäm21687, which is now kept in the storage facilities of the New Museum in Berlin. New research during the last number of years has confirmed this reading, although the writing of the name is different from that of the Merenptah inscription. Some characteristics appear to demonstrate that this inscription is older than the Israel stela of Merenptah and may likely date to the 14th or earlier 13th centurybce. The paper will present some ideas about an earlier beginning of the formation of what is generally called Israel and about the way, how this early Israel came about.
Shifting Political Terrains in “The City by the Bay” (“海湾之城” 政治角力转向 )
Authors: Lai (賴士宏) James S.
Published: November 2016

While the unchallenged November 2015 re-election of San Francisco Mayor Ed Lee was a telling moment in contemporary San Francisco politics, it was Mayor Ed Lee’s inaugural November 2011 election that revealed the shifting political terrains across its eleven Board of Supervisor districts that will likely shape the future role that Chinese Americans will play in the governing coalition of the “City by the Bay.” In the November 2011 San Francisco mayoral election, Ed Lee became the first Chinese American to be elected to lead this city. Despite the common explanation that Lee’s historic victory was due to the city’s first time use of the controversial ranked-choice voting (rcv) system, this study argues that whilercvwas an important factor in Lee’s election, other significant factors played a more prominent role. In particular, the two convergences taking shape between Chinese Americans/Asian Americans and the moderate governing coalition along the axes of Race/Space and Identity/Ideology were more significant to the outcome of Lee’s election than thercvprocess. In addition, the other significant factors that contributed to Ed Lee’s monumental election in 2011 include his previous public-service experience as a moderate coalition builder and the role of Chinese American community elites that advocated for the endorsement of Lee in both public and private settings with key moderate coalition leaders.

尽管李孟贤在 2015 年 11 月的地方选举中毫无悬念地顺利连任足以载入旧金山当代政治史册，追本溯源，其在4年前首次参选改变了旧金山监事会的政治力量对比，塑造了华人参政的未来。2011年11月，李当选为该市有史以来第一位华裔民选市长。李的历史性胜利，通常被认为是由于首次使用有争议的排列选择投票（rcv）制度所致。这项研究认为，尽管rcv是李当选的一个重要因素，但其他因素的作用也是不可忽视的，尤其是华裔/亚裔美国人与其他族裔群体围绕种族/空间以及族裔身份认同/意识形态的轴心而形成的温和执政联盟，对于李的竞选胜利比rcv起到更为显著的作用。此外，促成李孟贤在 2011 年市长大选胜利的其他显著因素还包括他以前的公共服务业绩，他本人在建构温和执政联盟中的所扮演的领导角色以及华人社区对他在不同场合中的温和政治主张的认同和大力支持。

This article is in English.
“You Need to Present a Counter-Message”
Authors: de Koning Martijn
Published: November 2016

Dutch researchers and activists have drawn attention to the huge number of Islamophobic events taking place; ranging from degrading remarks to violent attacks. In this article I look at the work of anti-Islamophobia initiatives within the broader framework of the racialisation of Muslims. Firstly, I argue that racialisation interpellates Dutch Muslims as an unacceptable “Other.” Secondly, I illustrate how anti-Islamophobia activism is informed by, and at the same time challenges, the racialisation of Muslims. In so doing I want to contribute to the debates about how Muslims are able to claim a ‘Muslim voice’ in a context in which racialisation seems all-encompassing.1
Morphology and distribution of Brevilinea kevei sp. nov. (Bacillariophyceae), a new diatom from Europe
Authors: ÁCS ÉVA , WETZEL CARLOS E. , HLÚBIKOVÁ DASA , GRIGORSZKY ISTVÁN , TRÁBERT ZSUZSA , ECTOR LUC
Published: November 2016

An unknown small naviculoid diatom was found in the epiphyton samples from Hungary (in Kanyari Holt-Tisza oxbow) and in the epilithon samples from France (Canal de Berry at Épineuil-le-Fleuriel). Detailed observations using light and scanning electron microscopy were used to describe Brevilinea kevei Ács & Ector sp. nov. It can be separated from Brevilinea pocosinensis Siver et al. (which was the only described species in the genus) by its size (smaller than B. pocosinensis), shape (elliptic valve, never capitate) and ecological requirements. Brevilinea pocosinensis lives in acidic conditions while B. kevei in neutral ones. Differential diagnostic criteria with respect to similar taxa, especially Fallacia indifferens (Hustedt) D.G. Mann, together with ecological implications of this finding are briefly discussed.
LALINET: The First Latin American–Born Regional Atmospheric Observational Network
Authors: Antuña-Marrero Juan Carlos , Landulfo Eduardo , Estevan René , Barja Boris , Robock Alan , Wolfram Elián , Ristori Pablo , Clemesha Barclay , Zaratti Francesco , Forno Ricardo , Armandillo Errico , Bastidas Álvaro E. , de Frutos Baraja Ángel M. , Whiteman David N. , Quel Eduardo , Barbosa Henrique M. J. , Lopes Fabio , Montilla-Rosero Elena , Guerrero-Rascado Juan L.
Published: November 2016

Sustained and coordinated efforts of lidar teams in Latin America at the beginning of the twenty-first century have built the Latin American Lidar Network (LALINET), the only observational network in Latin America created by the agreement and commitment of Latin American scientists. They worked with limited funding but an abundance of enthusiasm and commitment toward their joint goal. Before LALINET, there were a few pioneering lidar stations operating in Latin America, described briefly here. Biannual Latin American lidar workshops, held from 2001 to the present, supported both the development of the regional lidar community and LALINET. At those meetings, lidar researchers from Latin America met to conduct regular scientific and technical exchanges among themselves and with experts from the rest of the world. Regional and international scientific cooperation has played an important role in the development of both the individual teams and the network. The current LALINET status and activities are described, emphasizing the processes of standardization of the measurements, methodologies, calibration protocols, and retrieval algorithms. Failures and successes achieved in the buildup of LALINET are presented. In addition, the first LALINET joint measurement campaign and a set of aerosol extinction profile measurements obtained from the aerosol plume produced by the Calbuco volcano eruption on 22 April 2015 are described and discussed.
Work longer, better satisfaction? Financial and psychological satisfaction among Korean baby boomers and older workers
Authors: Kim Jeungkun , Kang Suk-Young
Published: November 2016

This study explores the differences in the financial and psychological satisfaction of three age cohorts and the factors contributing to those satisfaction levels among Korean baby boomers and older workers. The data of 1555 participants came from the Korean Welfare Panel Study from wave 1 (2006) to wave 8 (2013). The Chow test and multiple regressions were utilized to explore whether impacts differed by birth cohort and to identify unique factors associated with financial and psychological satisfaction. The results showed the ‘satisfaction paradox’ – a positive relationship between age and the financial satisfaction. Moreover, working longer played an important role in reducing depression, but not in increasing financial satisfaction.
The Relationship Between Violence Exposure and Academic Achievement in African American Adolescents Is Moderated by Emotion Regulation
Authors: King Vinetra L. , Mrug Sylvie
Published: November 2016

Compared with other ethnic groups, African American adolescents are exposed to higher levels of family and community violence, which contribute to poorer academic achievement. This study examines whether emotion regulation moderates the effects of exposure to family and community violence on academic achievement among low-income African American adolescents. Eighty African American adolescents ([Formula: see text] age 12.89 years, 50% male) reported on their exposure to violence. Emotion regulation was obtained from parent reports and academic achievement was assessed with grades in core academic subjects at baseline and 2 years later. Results revealed that witnessing home violence predicted poorer achievement over time, as did exposure to community violence for youth with poor emotion regulation. Thus, well-developed emotion regulation skills may protect African American adolescents from the negative effects of witnessing community violence on academic achievement.
Familial history of migraine influences habituation of visual evoked potentials
Authors: Lisicki Marco , Ruiz-Romagnoli Emiliano , D’Ostilio Kevin , Piedrabuena Raúl , Giobellina Roberto , Schoenen Jean , Magis Delphine
Published: November 2016

Background

Lack of habituation of visual evoked potentials (VEP) is a common finding in migraine patients between attacks. Previous studies have suggested an electrophysiological familial aggregation pattern associated with migraine. The aim of this study was to evaluate the influence of a positive familial history of migraine on VEP amplitude and habituation.

Methods

We recorded six blocks of 100 VEP during continuous pattern-reversal stimulation in 30 patients with migraine between attacks (MO) and in 30 healthy volunteers, of whom 15 had a first-degree relative suffering from migraine (HVm) and 15 had not (HV).

Results

Both MO and HVm had a significant deficit of VEP habituation and similarly reduced N1-P1 first block amplitudes, compared to HV (habituation slope: MO = 0.033, HVm = 0.021, HV = −0.025, HV vs. MO p = 0.002, HV vs. HVm p = 0.036; mean N1-P1 amplitude in the first block: MO = 9.08 µV, HVm = 9.29 µV, HV = 12.19 µV. HV vs. MO p = 0.041, HV vs. HVm p = 0.076). The first block N1-P1 amplitude was negatively correlated with the habituation slope for both MO (ρ = −.44, p = 0.015) and HVm (ρ = −.56, p = 0.031) while no significant correlation was found in HV (ρ = .17, p = 0.53). There were no differences in VEP latencies between the groups.

Conclusions

Our study suggests that lack of habituation of visual evoked potentials is probably a genetically determined endophenotypic trait that is associated with both migraine and migraine susceptibility. We hypothesize that genetic diversity of populations could account for some of the discrepancies between electrophysiological studies performed in migraine and for interindividual variations among the subgroups.
Modelling and analysis of coupled flap-lag-torsion vibration characteristics helicopter rotor blades
Authors: Castillo Pardo Alejandro , Goulos Ioannis , Pachidis Vassilios
Published: November 2016

This paper presents the development of a mathematical approach targeting the modelling and analysis of coupled flap-lag-torsion vibration characteristics of non-uniform continuous rotor blades. The proposed method is based on the deployment of Lagrange’s equation of motion to the three-dimensional kinematics of rotor blades. Modal properties derived from classical-beam and torsion theories are utilized as assumed deformation functions. The formulation, which is valid for hingeless, freely hinged and spring-hinged articulated rotor blades, is reduced to a set of closed-form integral expressions. Numerical predictions for mode shapes and natural frequencies are compared with experimental measurements, non-linear finite element analyses and multi-body dynamics analyses for two small-scale hingeless rotor blades. Excellent agreement is observed. The effect of different geometrical parameters on the elastic and inertial coupling is assessed. Additionally, the effect of the inclusion of gyroscopic damping is evaluated. The proposed method, which is able to estimate the first seven coupled modes of vibration in a fraction of a second, exhibits excellent numerical stability. It constitutes a computationally efficient alternative to multi-body dynamics and finite element analysis for the integration of rotor blade flexible modelling into a wider comprehensive rotorcraft tool.
Features for muscle fatigue computed from electromyogram and mechanomyogram: A new one
Authors: Okkesim Şükrü , Coşkun Kezban
Published: November 2016

Muscle fatigue produces negative effects in the performance and it may lead to a muscle failure. This problem makes the quantitative grading of muscle fatigue a necessity in ergonomic and physiological research. Moreover, the quantitative grading of muscle fatigue is needed to increase work and sport productivity and prevent several accidents that result from muscle fatigue. Even though there are many studies for this aim, there is no quantitative criterion for the evaluation of muscle fatigue. The main reason is that muscle fatigue is a complex physiological situation that is dependent on several parameters. Our aim in this study is to present a new feature to evaluate muscle fatigue and prove the reliability of the new feature by making correlation analyses between this with other features. For this aim, electromyography and mechanomyography signals were simultaneously recorded from the biceps brachii and triceps brachii muscles during the isometric and isotonic contractions of 60 healthy volunteers (30 females, 30 males). The mean power frequency and median frequency, which are used in the literature, were compared to the frequency ratio change, the new measure; correlations between the frequency ratio change and the mean power frequency and median frequency were analysed. There was a high correlation between the features, and frequency ratio change can be used to quantitatively evaluate muscle fatigue.
Reaching bandwidth saturation using transparent injection parallelization
Authors: Chaimov Nicholas , Ibrahim Khaled Z , Williams Samuel , Iancu Costin
Published: November 2016

Although logically available, applications may not exploit enough instantaneous communication concurrency to maximize network utilization on HPC systems. This is exacerbated in hybrid programming models that combine single program multiple data with OpenMP or CUDA. We present the design of a “multi-threaded” runtime able to transparently increase the instantaneous network concurrency and to provide near saturation bandwidth, independent of the application configuration and dynamic behavior. The runtime offloads communication requests from application level tasks to multiple communication servers. The servers use system specific performance models to attain network saturation. Our techniques alleviate the need for spatial and temporal application level message concurrency optimizations. Experimental results show improved message throughput and bandwidth by as much as 150% for 4 KB messages on InfiniBand and by as much as 120% for 4 KB messages on Cray Aries. For more complex operations such as all-to-all collectives, we observe as much as 30% speedup. This translates into 23% speedup on 12,288 cores for a NAS FT implemented using FFTW. We observe as much as 76% speedup on 1500 cores for an already optimized UPC+OpenMP geometric multigrid application using hybrid parallelism. For the geometric multigrid GPU implementation, we observe as much as 44% speedup on 512 GPUs.
Attention schema theory, an interdisciplinary turn? Cognition, culture and institutions
Authors: Frödin Olle
Published: November 2016

Moving beyond the distinction between biological and social facts has proved challenging due to several basic methodological and ontological differences among scientific disciplines. The aim of this paper is to show how attention schema theory (hereafter AST), developed by Michael Graziano, provides a useful addition to existing integrative approaches that can be used to overcome impediments to interdisciplinary cross-fertilization, such that the influence of a range of interconnected institutional, situational, biographical, psychological, neural and genetic variables can be considered simultaneously in a parsimonious way. The paper provides an overview of three basic methodological and ontological differences dividing scientists researching human nature and society. It then draws on AST and a selection of existing approaches in the interdisciplinary vein to demonstrate how to move beyond the reductionist tendencies of each discipline. In the view of AST, intrinsic brain processes and social and situational aspects are intricately intertwined and continuously influence each other in shaping specific attentional focuses. Social identities, biographical experiences, symbols, roles and subject positions contribute to directing attention to certain kinds of stimuli, details, or information, while at the same time, intrinsic predispositions make individuals inclined to attend to different types of information. By accounting for the brain basis of awareness as a subjective experience, AST can be used to clarify how social identities influence attention, and thus, the linkages between individual cognition and wider institutional structures. Finally, the paper considers the relationships between the cognitive and the institutional levels of analysis, and highlights the importance of the latter as a distinct level of analysis. In this way, the paper charts the multidirectional and interactive causal relationship between intrinsic brain processes, attention and conscious awareness, and how they relate to wider institutional structures and joint attentional interactions at higher levels of aggregation.