bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of long‐term risankizumab treatment for moderate‐to‐severe plaque psoriasis: Subgroup analyses by baseline characteristics and psoriatic disease manifestations through 256 weeks (LIMMitless trial)
Authors: Strober Bruce , Bachelez Hervé , Crowley Jeffrey , Elewski Boni E. , Gooderham Melinda , Menter Alan , Strohal Robert , Chen Michael M. , Wu Tianshuang , Zhan Tianyu , Photowala Huzefa , Armstrong April
Published: January 2024

Background

Psoriasis is an inflammatory skin disease that impacts a heterogeneous group of patients and can have multiple clinical manifestations. Risankizumab is approved for the treatment of moderate‐to‐severe plaque psoriasis.

Objectives

To evaluate the long‐term efficacy of risankizumab according to baseline patient characteristics, and for the treatment of high‐impact disease manifestations (nail, scalp and palmoplantar psoriasis), through 256 weeks of continuous treatment in the phase 3 LIMMitless study.

Methods

This subgroup analysis evaluated pooled data from patients with moderate‐to‐severe plaque psoriasis who were randomized to risankizumab 150 mg during two double‐blind, phase 3, 52‐week base studies (UltIMMa‐1/2; NCT02684370/NCT02684357) and were enrolled in the phase 3 LIMMitless open‐label extension study (NCT03047395). Subgroup assessments included the proportion of patients who achieved ≥90%/100% improvement in Psoriasis Area and Severity Index (PASI 90/100). Among patients with nail, scalp and/or palmoplantar psoriasis in addition to skin psoriasis, assessments included changes from baseline in and resolution of these three psoriatic manifestations.

Results

Overall, a numerically similar proportion of patients (N = 525) achieved PASI 90/100 through Week 256, regardless of their baseline age, sex, body mass index, weight, PASI or psoriatic arthritis status. Patients with nail, scalp and/or palmoplantar psoriasis experienced substantial improvements in manifestation‐specific indices (mean improvement from baseline to Week 256 of >81%, >94% and >97%, respectively); in patients with all three manifestations (N = 121), 44.6% achieved complete clearance of these manifestations at Week 256.

Conclusions

Risankizumab demonstrated generally consistent efficacy through 256 weeks across patient subgroups and showed durable long‐term efficacy for psoriatic disease manifestations.
Molecular characterization of ‘Candidatus Phytoplasma phoenicium’ infecting almond (Prunus dulcis) and evaluation of biochemical defenses produced in the plants
Authors: Akkurak Havva , Güldür Mehmet Ertuğrul , Dikilitas Murat , Karakas Sema , Alfaifi Mohammad Y. , Shati Ali A. , Sayyed Riyazali Z.
Published: January 2024

Increasing incidences of phytoplasma infestations in Almond trees warrants the better management approach to prevent yield losses. Disease management rely on identification of the pathogen based on molecular profiling. The present study aimed, to identify the phytoplasma agent in almond trees and to measure the biochemical responses it causes in the host. Direct and Nested PCRs performed using phytoplasma specific primer pairs 16S rRNA, detected the presence of phytoplasma agent in symptomatic trees but not in symptomless trees. Phylogeny based on the sequence analysis revealed that the infecting agent was closely related to ‘Candidatus Phytoplasma phoenicium’ (16SrIX‐B subgroup). Then the study was carried out to determine the responses of physiological and biochemical mechanisms in almond trees infected with phytoplasma. Total chlorophyll and protein contents of infected almond trees were lower compared to healthy control, on the other hand, the levels of catalase and peroxidase activity increased in infected trees. Higher levels of stress‐related metabolites such as proline (20.53–39.23 μmol/g), phenol (3.00–4.44 mg GAE/g), salicylic (94.96–138.22 ng SA/mg protein) and jasmonic acid (965.86–1465.10 ng JA/mg protein) were observed in infected trees compared to asymptomatic trees, respectively in healthy and infected trees. The results showed that the Ca. P. phoenicium, which was detected for the first time in Türkiye, was able to change the physiological and biochemical mechanisms. The pathogenic agent could possess a potential danger in almond production areas. It is crucially important that this agent should be considered in certification programs.
Fostering cultural competence: Exploring client perception in a health coaching intervention among college students
Authors: Oh Seungbin , Benes Sarah , Yan Zi
Published: January 2024

Health coaching could be an innovative approach to develop student coaches' cultural competence (CC) among future health professionals. The current mix‐method study design explored the impact of an 8‐week peer health coaching intervention among college students on CC, from both student health coaches (i.e., students majored in health sciences who completed health coaching training and acted as health coach) and student clients' perspective. Nine student coaches and 24 student clients participated in the study. The quantitative analysis showed an increase in the clients' perceived level of coaches' CC between the pre‐ and posttest. The qualitative analysis revealed three themes, including varying levels of awareness, respectful and culturally responsive coaching, and cultural connection. Implications and recommendations for educators and researchers are discussed.
A new variety of Commelina L.(Commelinaceae) from Eastern Ghats of Peninsular, India
Authors: Sivaramakrishna Pasupuleti , Yugandhar Pulicherla , Singh Lal Ji
Published: January 2024

Commelinabadamica var. palkondensis P. Sivaramakrishna, P. Yugandhar and L.J. Singh, var. nov. (Commelinaceae), a remarkable new variety from Palkonda hills of Eastern Ghats of Peninsular Indiais described and illustrated. It is apparently similar to C. badamica var. badamica in habitat ecology and general morphology, but differs in features like presence of a 2–3‐nerved ligule, lower cincinnus with single bisexual flower, glabrous ovary, elliptic anthers and ovoid‐oblong or trapezoidal seeds. In addition to the description, habitat ecology, details on population distribution and the conservation status are also provided for the new variety.
Randomized trial in postprandial functional dyspepsia: Reassurance and diagnostic explanation with or without traditional dietary advice
Authors: Buckle Rachel L. , Brown Lydia C. , Aziz Imran
Published: January 2024

Background

Almost 80% of individuals with functional dyspepsia experience meal‐related symptoms and are diagnosed with postprandial distress syndrome (PDS). However, studies evaluating dietary modifications in PDS are sparse. We performed a single‐center randomized trial comparing reassurance and diagnostic explanation (RADE) with or without traditional dietary advice (TDA) in PDS.

Methods

Following a normal upper gastrointestinal endoscopy, individuals with PDS were randomized to a leaflet providing RADE ± TDA; the latter recommending small, regular meals and reducing the intake of caffeine/alcohol/fizzy drinks and high‐fat/processed/spicy foods. Questionnaires were completed over 4 weeks, including self‐reported adequate relief of dyspeptic symptoms, and the validated Leuven Postprandial Distress Scale (LPDS), Gastrointestinal Symptom Rating Scale, and Nepean Dyspepsia Index for quality of life. The primary endpoint(s) to define clinical response were (i) ≥50% adequate relief of dyspeptic symptoms and (ii) >0.5‐point reduction in the PDS subscale of the LPDS (calculated as the mean scores for early satiety, postprandial fullness, and upper abdominal bloating).

Key Results

Of the 53 patients with PDS, 27 were assigned RADE‐alone and 26 to additional TDA. Baseline characteristics were similar between groups, with a mean age of 39 years, 70% female, 83% white British, and coexistent irritable bowel syndrome in 66%. The primary endpoints of (i) adequate relief of dyspeptic symptoms were met by 33% (n = 9) assigned RADE‐alone versus 39% (n = 10) with TDA; p‐value = 0.70, while (ii) a reduction of >0.5 points in the PDS subscale was met by 37% (n = 10) assigned RADE‐alone versus 27% (n = 7) with TDA; p‐value = 0.43. Response rates did not differ according to irritable bowel syndrome status. There were no significant between‐group changes in the gastrointestinal symptom rating scale and dyspepsia quality of life.

Conclusions & Inferences

This study of predominantly white British patients with PDS found the addition of TDA did not lead to significantly greater symptom reduction compared with RADE alone. Alternate dietary strategies should be explored in this cohort.
Identification of the novel HLA‐A*29:171 allele by next‐generation sequencing
Authors: Wu Zhipan , He Ji , Zhang Wei , He Yanmin , Zhu Faming
Published: January 2024

HLA‐A*29:171 differs from HLA‐A*29:01:01:01 by one nucleotide substitution at position 257T>G in exon 2.
Characterization of the novel HLA‐B*07:491 allele by next generation sequencing
Authors: Lion Julien , Da Costa Cecilia , Guillaume Nicolas , Desoutter Judith
Published: January 2024

HLA‐B*07:491 differs from HLA‐B*07:02:01 by one nucleotide substitution in codon 218 in exon 4.
Geographies of supplementary education: Private tuition, classed and racialised parenting cultures, and the neoliberal educational playing field
Authors: Holloway Sarah L. , Pimlott‐Wilson Helena , Whewall Sam
Published: January 2024

This paper makes two contributions to knowledge. First, it broadens geographies of education's focal reach by concentrating attention on the consumption of supplementary education. Supplementary education markets are booming as parents seek to ensure their children have the qualifications required to succeed in knowledge economies. The paper elucidates how consumption of such commercially provided tuition—which is delivered outside of school boundaries but designed to improve performance in school—is shaped by place‐specific, classed and racialised parenting cultures. This shines an important light on shadow education market mechanics that have hitherto been hidden from geographical view, and foregrounds the significant role parenting cultures play in shaping children's educational experiences. Future research in geographies of education must attend to these parenting cultures, as interactions between the home and diverse formal, informal, alternative and supplementary education settings play an increasingly crucial role in confronting and reproducing educational inequality. Second, the paper advances the conceptual contribution of geographies of education to interdisciplinary debates about parents and education. It demonstrates that multi‐scalar geographical research makes a unique contribution to interdisciplinary theorisations of home–school links, including those utilising Bourdieu's notion of cultural reproduction, and Lareau's model of concerted cultivation. Specifically, multi‐scalar analysis demonstrates that: (i) place‐sensitive research is vital as it contextualises parenting cultures, reattaching analyses of parental habitus and capital to the field, highlighting how intersecting global, national and local processes shape parents' educational practices; (ii) previously overlooked racial differences in concerted cultivation must be analysed without being naturalised, by exploring how racialised dispositions towards education are shaped in/across place, and reproduced through global/local racialised social capital; and (iii) inter‐class differences that have dominated parenting debates remain important, but attention to inter‐class similarity and intra‐class variation, as it emerges through intersections with race and in place, is equally vital.
In vitro evaluation of bactericidal effects of fluorescent light energy on Staphylococcus pseudintermedius and S. aureus
Authors: Lundberg Annette T. , Hathcock Terri , Kennis Robert A. , White Amelia G.
Published: January 2024

Background

Staphylococcus pseudintermedius and S. aureus are bacterial species of importance in veterinary medicine. The increasing incidence of antibiotic resistance necessitates the implementation of novel treatment modalities. Fluorescent light energy (FLE) is used as an adjunctive and primary treatment for canine pyoderma. However, no in vitro studies exist investigating its bactericidal effects against S. pseudintermedius or S. aureus.

Objectives

To determine the bactericidal effects of FLE on S. pseudintermedius and S. aureus isolates.

Materials and Methods

Two meticillin‐susceptible S. pseudintermedius (MSSP) isolates, three meticillin‐resistant S. pseudintermedius (MRSP) isolates and one meticillin‐resistant S. aureus (MRSA) isolate were studied. A commercially available blue light‐emitting diode (bLED) lamp and photoconverting hydrogel FLE system was used. All bacteria were exposed to five conditions following inoculation: (i) no treatment (control); (ii) blue light (bLED) once; (iii) bLED twice consecutively; (iv) FLE (bLED and photoconverting hydrogel) once; and (v) FLE (bLED and photoconverting hydrogel) twice consecutively. Each individual exposure was 2 min long.

Results

No statistically significant differences (p < 0.05) were found for any treatment group when each bacterial isolate was evaluated individually, MSSP isolates were grouped, MRSP isolates were grouped, when all S. pseudintermedius isolates were combined, or when all isolates of both Staphylococcus species were combined.

Conclusions and Clinical Relevance

While clinical success is reported when using FLE to treat Staphylococcus infections in animals, no in vitro antibacterial efficacy was identified for S. pseudintermedius or S. aureus under experimental conditions. The clinical success observed with FLE may be the result of a more complex in vivo response.
Linnean shortfall and space‐time patterns in species description of New World coralsnakes (Serpentes: Elapidae)
Authors: Frateles Lívia Estéfane Fernandes , da Silva Nelson Jorge , Terribile Levi Carina , Diniz‐Filho José Alexandre Felizola
Published: January 2024

The magnitude of life on Earth and human limitations hinder the understanding of even the most basic aspects of biodiversity, such as the identity of species inhabiting the Earth, the so‐called Linnean shortfall. Evaluating patterns in species description dates and their relationship with macroecological variables can help guide where taxonomic efforts should be focused. Therefore, we aim to assess the Linnean shortfall in the knowledge of New World coralsnake biodiversity. We modelled species description dates and estimated that approximately one‐third of the coralsnake diversity remains unknown. The undescribed species are evolutionarily closely related to the already described species. Moreover, recently described species in the group have more restricted geographic ranges and tend to be small‐bodied. The western Amazon and the dry diagonal (i.e. Caatinga, Cerrado, and Chaco) are the areas with the oldest description dates. However, assemblages in these areas have the largest average geographic distances to the type locality of their species, suggesting that little taxonomic effort has been dedicated intrinsically to these regions. We suggest that allocating taxonomic efforts to the dry diagonal and the use of integrative taxonomic techniques for better species delimitation are imperative to fill the Linnean shortfall for the New World coralsnakes.
Sin pasado no hay futuro
Authors:   Universidad de Jaén, Anta Félez José Luis
Published: January 2024

Beatriz y yo teníamos una amistad larga y bonita, no nos veíamos mucho porque vivo lejos de todo, pero cuando nos encontrábamos todo era un no parar de contarnos, de ponernos al día y rápidamente construíamos un marco de complicidades. Compartimos muchas cosas y nos definían básicamente dos: decimos lo que pensábamos, Beatriz, además, pensaban muy bien lo que decía y lo hacía muy bien. Y segundo, siempre vimos la antropología como un arma de combate que nos permitía ver y, en su caso volar, más lejos. (...)
Freeform direct-write and rewritable photonic integrated circuits in phase-change thin films
Authors: Wu Changming , Deng Haoqin , Huang Yi-Siou , Yu Heshan , Takeuchi Ichiro , Ríos Ocampo Carlos A. , Li Mo
Published: January 2024

Photonic integrated circuits (PICs) with rapid prototyping and reprogramming capabilities promise revolutionary impacts on a plethora of photonic technologies. We report direct-write and rewritable photonic circuits on a low-loss phase-change material (PCM) thin film. Complete end-to-end PICs are directly laser-written in one step without additional fabrication processes, and any part of the circuit can be erased and rewritten, facilitating rapid design modification. We demonstrate the versatility of this technique for diverse applications, including an optical interconnect fabric for reconfigurable networking, a photonic crossbar array for optical computing, and a tunable optical filter for optical signal processing. By combining the programmability of the direct laser writing technique with PCM, our technique unlocks opportunities for programmable photonic networking, computing, and signal processing. Moreover, the rewritable photonic circuits enable rapid prototyping and testing in a convenient and cost-efficient manner, eliminate the need for nanofabrication facilities, and thus promote the proliferation of photonics research and education to a broader community.
Protecting and connecting landscapes stabilizes populations of the Endangered savannah elephant
Authors: Huang Ryan M. , Maré Celesté , Guldemond Robert A. R. , Pimm Stuart L. , van Aarde Rudi J.
Published: January 2024

The influence of protected areas on the growth of African savannah elephant populations is inadequately known. Across southern Africa, elephant numbers grew at 0.16% annually for the past quarter century. Locally, much depends on metapopulation dynamics—the size and connections of individual populations. Population numbers in large, connected, and strictly protected areas typically increased, were less variable from year to year, and suffered less from poaching. Conversely, populations in buffer areas that are less protected but still connected have more variation in growth from year to year. Buffer areas also differed more in their growth rates, likely due to more threats and dispersal opportunities in the face of such dangers. Isolated populations showed consistently high growth due to a lack of emigration. This suggests that “fortress” conservation generally maintains high growth, while anthropogenic-driven source-sink dynamics within connected conservation clusters drive stability in core areas and variability in buffers.
Encoded sewing soft textile robots
Authors: Guo Xinyu , Li Wenbo , Fang Fuyi , Chen Huyue , Zhao Linchuan , Fang Xiaoyong , Yi Zhiran , Shao Lei , Meng Guang , Zhang Wenming
Published: January 2024

Incorporating soft actuation with soft yet durable textiles could effectively endow the latter with active and flexible shape morphing and motion like mollusks and plants. However, creating highly programmable and customizable soft robots based on textiles faces a longstanding design and manufacturing challenge. Here, we report a methodology of encoded sewing constraints for efficiently constructing three-dimensional (3D) soft textile robots through a simple 2D sewing process. By encoding heterogeneous stretching properties into three spatial seams of the sewed 3D textile shells, nonlinear inflation of the inner bladder can be guided to follow the predefined spatial shape and actuation sequence, for example, tendril-like shape morphing, tentacle-like sequential manipulation, and bioinspired locomotion only controlled by single pressure source. Such flexible, efficient, scalable, and low-cost design and formation methodology will accelerate the development and iteration of soft robots and also open up more opportunities for safe human-robot interactions, tailored wearable devices, and health care.
Structural insights into the molecular mechanism of high-level ceftazidime–avibactam resistance conferred by CMY-185
Authors: Kawai Akito , Shropshire William C. , Suzuki Masahiro , Borjan Jovan , Aitken Samuel L. , Bachman William C. , McElheny Christi L. , Bhatti Micah M. , Shields Ryan K. , Shelburne Samuel A. , Doi Yohei
Published: January 2024

Ceftazidime-avibactam has a broad spectrum of activity against multidrug-resistant Gram-negative bacteria including carbapenem-resistant
Enterobacterales
including strains with or without production of serine carbapenemases. After its launch, emergence of ceftazidime-avibactam-resistant strains that produce mutated β-lactamases capable of efficiently hydrolyzing ceftazidime or impairing avibactam inhibition are increasingly reported. Furthermore, cross-resistance towards cefiderocol, the latest cephalosporin in clinical use, has been observed in some instances. Here, we clearly demonstrate the functional role of the substituted residues in CMY-185, a four amino-acid variant of CMY-2 identified in a patient treated with ceftazidime-avibactam, for high-level resistance to this agent and low-level resistance to cefiderocol. These findings provide structural insights into how β-lactamases may incrementally alter their structures to escape multiple advanced β-lactam agents.
A novel combination of filamin C mutation and cardiorespiratory sarcoidosis in a patient with left ventricular systolic dysfunction
Authors: Wasef Mohammad , Guha Kaushik
Published: January 2024

Cardiac sarcoidosis is an unpredictable, rare and potentially lethal condition whereby patients are exposed to sudden cardiac death. However, despite sophisticated imaging techniques and the need for careful multidisciplinary team assessment and management, the contribution from genetic mutations is uncertain. Hence, the case describes a novel observation of a patient who possessed both a filamin C mutation and cardiac sarcoidosis. The case highlights the need for detailed dedicated investigation and highlights the need for the consideration of genetic screening within patients with cardiac sarcoidosis.
Rowing and pain: does rowing lead to exercise-induced hypoalgesia?
Authors: Tomschi Fabian , Herzig Steffen , Hilberg Thomas
Published: January 2024

Physical activity acutely alters pain processing known as exercise-induced hypoalgesia (EIH). This randomized controlled crossover study investigated the effects of two different rowing exercises on EIH and to explore whether possible EIH effects are related to individual rowing specific performance. Fifty male experienced rowers conducted two rowing sessions (submaximal: 30 min of moderate rowing (70% of maximum heart rate); maximal: 350 m in an all-out fashion) and a control session. Pre and post exercise pain sensitivity was measured bilaterally using pressure pain thresholds (PPT; Newton (N)) at the elbow, knee, ankle, sternum, and forehead. Individual performance was determined as maximum watt/kg and was tested for correlations with changes in PPT. Higher PPT values were observed after maximal exercise at all landmarks with a mean change ranging from 2.5 ± 7.8 N (right elbow; p = 0.027; dz = 0.323) to 10.0 ± 12.2 N (left knee; p ≤ 0.001; dz = 0.818). The submaximal (range from −1.6 ± 8.8 N (Sternum; p = 0.205; dz = 0.182) to 2.0 ± 10.3 N (right ankle; p = 0.176; dz = 0.194)) and control session (range from −0.5 ± 7.6 N (left elbow; p = 0.627; dz = 0.069) to 2.6 ± 9.1 N (right ankle; p = 0.054; dz = 0.279)) did not induce changes. Relative performance levels were not correlated to EIH (range from: r = −0.129 ( p = 0.373) at sternum to r = 0.176 ( p = 0.221) at left knee). EIH occurred globally after a short maximal rowing exercise while no effects occurred after rowing for 30 min at submaximal intensity. EIH cannot be explained by rowing specific performance levels in experienced rowers. However, the sample may lack sufficient heterogeneity in performance levels to draw final conclusions.
Impact of vector meson polarization on its interaction with matter
Authors: Gevorkyan S. R. , Guskov A. V.
Published: January 2024

The production of unstable particles on different nuclei provides the possibility to determine the total cross section of the interaction of vector mesons $$V=\rho ,\omega ,\varphi , K^{*0}(892),J/\psi $$

V
=
ρ
,
ω
,
φ
,

K

∗
0

(
892
)

,
J
/
ψ

etc. with nucleons. This interaction is defined by a set of amplitudes that correspond to the transverse (helicity $$\lambda =\pm 1$$

λ
=
±
1

) or longitudinal ($$\lambda =0$$

λ
=
0

) polarization of the vector meson. The total cross section for the interaction of transversely polarized vector mesons with nucleon $$\sigma _T=\sigma (V_T N)$$

σ
T

=
σ

(

V
T

N
)

has been extracted from the coherent photoproduction of vector mesons off nuclei, while the vector meson production in charge exchange reactions as $$\pi ^\pm (K^\pm )+A\rightarrow V^0(K^{*0})+A'$$

π
±

(

K
±

)

+
A
→

V
0

(

K

∗
0

)

+

A
′

provides the unique opportunity to obtain the not yet measured total cross section for longitudinally polarized vector meson interacting with nucleon $$\sigma _L=\sigma (V_L N)$$

σ
L

=
σ

(

V
L

N
)

. We shortly discuss the importance of the knowledge of $$\sigma _L$$

σ
L

and possibility to extract its value from experiments on nuclear target.
ONLINE CROWDFUNDING PROJECTS AFTER THE PANDEMIC: ENTREPRENEURIAL ABILITIES AND INSTITUTIONAL DYNAMICS
Authors: GUO ANDREW , TANG LINGHUI
Published: January 2024

This study examines what institutional conditions, entrepreneurial abilities and industry-specific factors contributed to the survival of online crowdfunding projects after the Covid pandemic. Based on the dynamic capability theory, we argue that government financial support alone cannot close the gap between market supply and demand after an exogenous shock. An institutional environment that promotes a transparent and efficient information sharing and resources allocation system is equally important for the survival of startups. Using a sample of 924 Kickstarter projects between 2017 and 2018, we found that startups in countries with high market dynamics and low entry barriers had a higher probability to survive the exogenous shock after controlling for entrepreneurial experience, social capital, and industry-specific factors. The findings support a free market approach to promote early-stage entrepreneurship.
Two-dimensional image zooming by adaptive Sinc-based technique
Authors: Ciulla Carlo , Shabani Blerta , Doda Grisilda , Hoxha Romina , Zaimaj Sonila
Published: January 2024

This article reports a novel adaptive Sinc-based zooming technique. The theoretical basis of the zooming technique is the Whittaker–Shannon interpolation formula and the Nyquist–Shannon sampling theorem. The technique can be used to zoom out, zoom in, and reconstruct two-dimensional images with no zoom. The technique introduces a novel concept called pixel-local-scaled k-space, which is calculated as follows. The k-space magnitude and the bandwidth of the image to zoom are calculated. The bandwidth of the frequency components of the image to zoom is estimated by the difference between the maximum and the minimum numerical value of the k-space magnitude. The ratio between the standardised k-space magnitude of the image and the bandwidth is calculated pixel-by-pixel, and is called pixel-local-scaled k-space. The signal is reconstructed using a finite convolution between image pixel intensities and Sinc functions. The zooming factor is consequential to the numerical difference between the pixel-local-scaled k-space and the sampling rate. The novelty of this zooming technique is to be adaptive because the pixel-local-scaled k-space is a pixel-by-pixel map, that is, an image with the same number of pixels as the departing image. Adaptive Sinc-based zooming is validated through the comparison with non-adaptive Sinc-based zooming, and its smoothing effect is compared to the smoothing of a variety of image space and z-space filters. The adaptive Sinc-based zooming technique achieves image zooming reconstruction using sampling rates within an extended range versus the range allowed by non-adaptive Sinc-based zooming.
Sustainability in Computing Education: A Systematic Literature Review
Authors: Peters Anne-Kathrin , Capilla Rafael , Coroamă Vlad Constantin , Heldal Rogardt , Lago Patricia , Leifler Ola , Moreira Ana , Fernandes João Paulo , Penzenstadler Birgit , Porras Jari , Venters Colin C.
Published: January 2024

Research shows that the global society as organized today, with our current technological and economic system, is impossible to sustain. We are living in an era in which human activities in highly industrialized countries are responsible for overshooting several planetary boundaries, with poorer communities contributing the least to the problems but being impacted the most. At the same time, technical and economic gains fail to provide society at large with equal opportunities and improved quality of life. This article describes approaches taken in computing education to address the issue of sustainability. It presents results of a systematic review of the literature on sustainability in computing education. From a set of 572 publications extracted from six large digital libraries plus snowballing, we distilled and analyzed 89 relevant primary studies. Using an inductive and deductive thematic analysis, we study (i) conceptions of sustainability, computing, and education; (ii) implementations of sustainability in computing education; and (iii) research on sustainability in computing education. We present a framework capturing learning objectives and outcomes as well as pedagogical methods for sustainability in computing education. These results can be mapped to existing standards and curricula in future work. We find that only a few of the articles engage with the challenges as calling for drastic systemic change, along with radically new understandings of computing and education. We suggest that future work should connect to the substantial body of critical theory, such as feminist theories of science and technology. Existing research on sustainability in computing education may be considered rather immature, as the majority of articles are experience reports with limited empirical research.
Robust Classification and 6D Pose Estimation by Sensor Dual Fusion of Image and Point Cloud Data
Authors: Xu Yaming , Wang Yan , Li Boliang
Published: January 2024

It is an important aspect to fully leverage complementary sensors of images and point clouds for objects classification and six-dimensional (6D) pose estimation tasks. Prior works extract objects category from a single sensor such as RGB camera or LiDAR, limiting their robustness in the event that a key sensor is severely blocked or fails. In this work, we present a robust objects classification and 6D object pose estimation strategy by dual fusion of image and point cloud data. Instead of solely relying on 3D proposals or mature 2D object detectors, our model deeply integrates 2D and 3D information of heterogeneous data sources by a robustness dual fusion network and an attention-based nonlinear fusion function Attn-fun(.), achieving efficiency as well as high accuracy classification for even missed some data sources. Then, our method is also able to precisely estimate the transformation matrix between two input objects by minimizing the feature difference to achieve 6D object pose estimation, even under strong noise or with outliers. We deploy our proposed method not only to ModelNet40 datasets but also to a real fusion vision rotating platform for tracking objects in outer space based on the estimated pose.
Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications
Authors: Abdelazim Aaser M. , Afifi Mohamed , Abu-Alghayth Mohammed H. , Alkadri Dima H.
Published: January 2024

Plants could be used for multiple medicinal purposes. Moringa oleifera (MO) is considered the most famous plant used for this purpose. The present review aimed to spot the light on the recent medicinal, biochemical, and nutritional applications of MO. The plant contains a huge number of nutrients such as fatty acids, amino acids, proteins, polysaccharides, minerals, and vitamins. It has been used to control glucose, lipids, proteins, minerals, vitamins, hormones, and antioxidants in many animals and human models. Its medicinal applications are also varied and wide; it could be used to control and manage lots of disorders. Extracts and isolated ingredients from the plant open the way for many researchers all over the world to study its biochemical and medicinal impact on many experimental and clinical models. The present review spots the light on the recent medicinal and biochemical significance of MO opening the discussion and demonstrating the strengths and weaknesses in the MO research area. Regardless of the contrary concept, we considered MO a promising plant that could be studied for its medicinal applications on both biochemical and molecular levels. We recommended further research on the molecular effects of MO in healthy and diseased models.
Use of Antidepressant and Anxiolytic Drugs in Scandinavian Countries between 2006 and 2021: A Prescription Database Study
Authors: Bojanić Ivana
Published: January 2024

Introduction. The use of antidepressant and anxiolytic drugs has changed in Scandinavian countries over recent decades, with notable national variations. Objective. To describe and compare antidepressant and anxiolytic drug use in Norway, Sweden, and Denmark. Methods. Data included each country’s prescription registers from 2006 to 2021. The measures were period (1-year) prevalence (users per 1000 inhabitants) and therapeutic intensity (TI; daily defined dose (DDD) per 1000 inhabitants per day), overall, by drug classes and age groups. Results. The prevalence of antidepressant use increased from 2006 to 2021 and was highest in Sweden (78 to 107 users per 1000 inhabitants) and lowest in Norway (61 to 69 users per 1000 inhabitants). The prevalence of anxiolytic use decreased, most steeply in Denmark (50 to 18 users per 1000 inhabitants). The TI of antidepressants increased consistently in Norway and Sweden, but more variably in Denmark. Sweden had the highest increase in TI of antidepressants (56%). The TI of anxiolytics declined most markedly in Denmark (by 75%). The prevalence of antidepressant and anxiolytic use was highest among adults ≥65 years. The prevalence of antidepressant use increased across age groups in Sweden and young people (5-19 years) in Norway, but not in Denmark. Conclusions. The use of antidepressants increased in Scandinavia in 2006-2021, but decreased for anxiolytics, with country variations in the number of users and the amount used. Future research should target factors underlying high antidepressant and anxiolytic use in older adults across countries and increasing antidepressant use in Sweden and among young Norwegians.
Simultaneous Determination of Mineral Nutrients and Toxic Metals in M. stenopetala from Southern Ethiopia: A Comparative Study of Three Cultivating Areas Using MP-AES
Authors: Shemnsa Ashenafi , Adane Wondimeneh Dubale , Tessema Merid , Tesfaye Endale , Tesfaye Gizaw
Published: January 2024

In this study, for the first time, the levels of thirteen micro- and macromineral nutrients in the leaves, seeds, and supportive soil of Moringa stenopetala (M. stenopetala) were simultaneously determined using microwave plasma atomic emission spectroscopy (MP-AES). The samples were collected during the arid season, in 2019 from the three main M. stenopetala growing areas in southern Ethiopia (Chano Mile Kebele, Nechisar Kebele, and Konso Special Woreda). A novel digestion method for leaf and seed samples was developed using an optimized acid mixture (2.5 : 0.75 : 0.5 of HNO3, HClO4, and H2O2) at 240°C for 2 hrs and 30 min, resulting in clear and colorless solutions. The method makes the digestion process more efficient by minimizing the reagent volume, reducing digestion temperature and time, and simplifying the overall procedure. The efficiency of the optimized procedure was validated by spiking experiments, and the percentage recovery ranged between 94 and 110%. Under optimized experimental conditions, higher concentrations of essential minerals (K, Na, Ca, and Mg) were observed in the plant leaf and seed samples from the three areas. In addition, significant amounts of trace elements (Fe, Mn, Zn, and Cu) were also found. Importantly, no traces of the toxic elements (Cd and Pb) were detected in any of the analyzed samples, suggesting that the leaves and seeds of M. stenopetala are valuable sources of both micro- and macromineral nutrients and are safe from toxic metals. From a dietary perspective, the seed contains almost comparable concentrations of minerals as the leaves. As a result, the seeds of M. stenopetala can serve as an alternative source of minerals and play a role in overcoming the current global food crisis, particularly in the dry season. Analysis of variance at a 95% confidence level revealed significant differences in the levels of all mineral nutrients between the three sample means except K, Ca, Co, and Cu. Generally, the developed method includes an innovative digestion procedure that minimizes reagent consumption, operates at lower temperatures, and requires shorter digestion times, thereby optimizing resource utilization and maintaining analytical accuracy. Notably, the absence of toxic elements in the MP-AES procedure highlights the safety and reliability of M. stenopetala leaves and seeds as valuable, contamination-free sources of essential nutrients.
Supplementary Tables 1 from FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner
Authors: Pifer Phillip M. , Yang Liangpeng , Kumar Manish , Xie Tongxin , Frederick Mitchell , Hefner Andrew , Beadle Beth , Molkentine David , Molkentine Jessica , Dhawan Annika , Abdelhakiem Mohamed , Osman Abdullah A. , Leibowitz Brian J. , Myers Jeffrey N. , Pickering Curtis R. , Sandulache Vlad C. , Heymach John , Skinner Heath D.
Published: January 2024

Supplementary Tables
Supplementary Figure S3 from Inhibition of PORCN Blocks Wnt Signaling to Attenuate Progression of Oral Carcinogenesis
Authors: Peña-Oyarzún Daniel , Flores Tania , Torres Vicente A. , Quest Andrew F.G. , Lobos-González Lorena , Kretschmar Catalina , Contreras Pamela , Maturana-Ramírez Andrea , Criollo Alfredo , Reyes Montserrat
Published: January 2024

Original Western Blot images
Supp Figure 4 from FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner
Authors: Pifer Phillip M. , Yang Liangpeng , Kumar Manish , Xie Tongxin , Frederick Mitchell , Hefner Andrew , Beadle Beth , Molkentine David , Molkentine Jessica , Dhawan Annika , Abdelhakiem Mohamed , Osman Abdullah A. , Leibowitz Brian J. , Myers Jeffrey N. , Pickering Curtis R. , Sandulache Vlad C. , Heymach John , Skinner Heath D.
Published: January 2024

Supp Figure 4
Supplementary Table S4 from A Fully Automated Deep-Learning Model for Predicting the Molecular Subtypes of Posterior Fossa Ependymomas Using T2-Weighted Images
Authors: Cheng Dan , Zhuo Zhizheng , Du Jiang , Weng Jinyuan , Zhang Chengzhou , Duan Yunyun , Sun Ting , Wu Minghao , Guo Min , Hua Tiantian , Jin Ying , Peng Boyang , Li Zhaohui , Zhu Mingwang , Imami Maliha , Bettegowda Chetan , Sair Haris , Bai Harrison X. , Barkhof Frederik , Liu Xing , Liu Yaou
Published: January 2024

The 12 incorrectly predicted cases with PF-EPN using T2-nnU-net
Supplementary Document S2 from A Fully Automated Deep-Learning Model for Predicting the Molecular Subtypes of Posterior Fossa Ependymomas Using T2-Weighted Images
Authors: Cheng Dan , Zhuo Zhizheng , Du Jiang , Weng Jinyuan , Zhang Chengzhou , Duan Yunyun , Sun Ting , Wu Minghao , Guo Min , Hua Tiantian , Jin Ying , Peng Boyang , Li Zhaohui , Zhu Mingwang , Imami Maliha , Bettegowda Chetan , Sair Haris , Bai Harrison X. , Barkhof Frederik , Liu Xing , Liu Yaou
Published: January 2024

Next-generation sequencing
Figure S3 from Analysis of Tumor Microenvironment Changes after Neoadjuvant Chemotherapy with or without Bevacizumab in Advanced Ovarian Cancer (GEICO-89T/MINOVA Study)
Authors: Tavira Beatriz , Iscar Teresa , Manso Luis , Santaballa Ana , Gil-Martin Marta , García García Yolanda , Romeo Margarita , Iglesias Maria , de Juan Ferré Ana , Barretina-Ginesta María Pilar , Manzano Aranzazu , Gaba Lydia , Rubio María Jesús , de Andrea Carlos E. , González-Martín Antonio
Published: January 2024

Supplementary Figure 3. Association analysis between CD 8 +/CD 4 FOXP 3 ratio and progression free survival (PFS).
Figure S2 from Analysis of Tumor Microenvironment Changes after Neoadjuvant Chemotherapy with or without Bevacizumab in Advanced Ovarian Cancer (GEICO-89T/MINOVA Study)
Authors: Tavira Beatriz , Iscar Teresa , Manso Luis , Santaballa Ana , Gil-Martin Marta , García García Yolanda , Romeo Margarita , Iglesias Maria , de Juan Ferré Ana , Barretina-Ginesta María Pilar , Manzano Aranzazu , Gaba Lydia , Rubio María Jesús , de Andrea Carlos E. , González-Martín Antonio
Published: January 2024

Supplementary Figure 2. Association between progression free survival (PFS) and immune populations presence.
Supplementary Table S4 from Tumor Volume Growth Rates and Doubling Times during Active Surveillance of IDH-mutant Low-Grade Glioma
Authors: Bhatia Ankush , Moreno Raquel , Reiner Anne S. , Nandakumar Subhiksha , Walch Henry S. , Thomas Teena M. , Nicklin Philip J. , Choi Ye , Skakodub Anna , Malani Rachna , Prabhakaran Vivek , Tiwari Pallavi , Diaz Maria , Panageas Katherine S. , Mellinghoff Ingo K. , Bale Tejus A. , Young Robert J.
Published: January 2024

Supplementary Table S4. Clinical Characteristics and Tumor Volume Growth During Active Surveillance.
Supplementary Table S1 from Tumor Volume Growth Rates and Doubling Times during Active Surveillance of IDH-mutant Low-Grade Glioma
Authors: Bhatia Ankush , Moreno Raquel , Reiner Anne S. , Nandakumar Subhiksha , Walch Henry S. , Thomas Teena M. , Nicklin Philip J. , Choi Ye , Skakodub Anna , Malani Rachna , Prabhakaran Vivek , Tiwari Pallavi , Diaz Maria , Panageas Katherine S. , Mellinghoff Ingo K. , Bale Tejus A. , Young Robert J.
Published: January 2024

Supplementary Table S1. Alterations in Molecular-Grade High Group IDH-mutant Gliomas.
Supplementary Figure S3 from Overall Survival and Exploratory Biomarker Analyses of Abemaciclib plus Trastuzumab with or without Fulvestrant versus Trastuzumab plus Chemotherapy in HR+, HER2+ Metastatic Breast Cancer Patients
Authors: Tolaney Sara M. , Goel Shom , Nadal Jorge , Denys Hannelore , Borrego Manuel R. , Litchfield Lacey M. , Liu Jiangang , Appiah Adams K. , Chen Yanyun , André Fabrice
Published: January 2024

Progression-free survival (PFS) and overall survival (OS) for intrinsic subtypes in Arm C.
Supplementary Figure S2 from Tumor Volume Growth Rates and Doubling Times during Active Surveillance of IDH-mutant Low-Grade Glioma
Authors: Bhatia Ankush , Moreno Raquel , Reiner Anne S. , Nandakumar Subhiksha , Walch Henry S. , Thomas Teena M. , Nicklin Philip J. , Choi Ye , Skakodub Anna , Malani Rachna , Prabhakaran Vivek , Tiwari Pallavi , Diaz Maria , Panageas Katherine S. , Mellinghoff Ingo K. , Bale Tejus A. , Young Robert J.
Published: January 2024

Supplementary Figure S2. Tumor volume growth rates and respective genomics.
Supplementary Figure S1 from Overall Survival and Exploratory Biomarker Analyses of Abemaciclib plus Trastuzumab with or without Fulvestrant versus Trastuzumab plus Chemotherapy in HR+, HER2+ Metastatic Breast Cancer Patients
Authors: Tolaney Sara M. , Goel Shom , Nadal Jorge , Denys Hannelore , Borrego Manuel R. , Litchfield Lacey M. , Liu Jiangang , Appiah Adams K. , Chen Yanyun , André Fabrice
Published: January 2024

REMARK (Reporting Recommendations for Tumor Marker Prognostic Studies) diagram for patients in the monarcHER trial.
Supplementary Table S6 from Intraoperative Integrated Diagnostic System for Malignant Central Nervous System Tumors
Authors: Hayashi Takahiro , Tateishi Kensuke , Matsuyama Shinichiro , Iwashita Hiromichi , Miyake Yohei , Oshima Akito , Honma Hirokuni , Sasame Jo , Takabayashi Katsuhiro , Sugino Kyoka , Hirata Emi , Udaka Naoko , Matsushita Yuko , Kato Ikuma , Hayashi Hiroaki , Nakamura Taishi , Ikegaya Naoki , Takayama Yutaro , Sonoda Masaki , Oka Chihiro , Sato Mitsuru , Isoda Masataka , Kato Miyui , Uchiyama Kaho , Tanaka Tamon , Muramatsu Toshiki , Miyake Shigeta , Suzuki Ryosuke , Takadera Mutsumi , Tatezuki Junya , Ayabe Junichi , Suenaga Jun , Matsunaga Shigeo , Miyahara Kosuke , Manaka Hiroshi , Murata Hidetoshi , Yokoyama Takaakira , Tanaka Yoshihide , Shuto Takashi , Ichimura Koichi , Kato Shingo , Yamanaka Shoji , Cahill Daniel P. , Fujii Satoshi , Shankar Ganesh M. , Yamamoto Tetsuya
Published: January 2024

IDH- and pTERT-wildtype gliomas at intraoperative integrated diagnosis in the prospective cohort
Supplementary Table S1 from Landscape of Clinical Resistance Mechanisms to FGFR Inhibitors in FGFR2-Altered Cholangiocarcinoma
Authors: Wu Qibiao , Ellis Haley , Siravegna Giulia , Michel Alexa G. , Norden Bryanna L. , Fece de la Cruz Ferran , Balasooriya Eranga Roshan , Zhen Yuanli , Silveira Vanessa S. , Che Jianwe , Corcoran Ryan B. , Bardeesy Nabeel
Published: January 2024

Supplementary Table 1. Baseline clinical characteristics of patients with FGFR2-altered intrahepatic cholangiocarcinoma (N=82)
Supplementary Figure S1 from Landscape of Clinical Resistance Mechanisms to FGFR Inhibitors in FGFR2-Altered Cholangiocarcinoma
Authors: Wu Qibiao , Ellis Haley , Siravegna Giulia , Michel Alexa G. , Norden Bryanna L. , Fece de la Cruz Ferran , Balasooriya Eranga Roshan , Zhen Yuanli , Silveira Vanessa S. , Che Jianwe , Corcoran Ryan B. , Bardeesy Nabeel
Published: January 2024

Alternative resistance pathways
Supplementary Figure S3 from PET/CT Biomarkers Enable Risk Stratification of Patients with Relapsed/Refractory Diffuse Large B-cell Lymphoma Enrolled in the LOTIS-2 Clinical Trial
Authors: Alderuccio Juan Pablo , Reis Isildinha M. , Hamadani Mehdi , Nachiappan Muthiah , Leslom Salman , Kahl Brad S. , Ai Weiyun Z. , Radford John , Solh Melhem , Ardeshna Kirit M. , Hess Brian T. , Lunning Matthew A. , Zinzani Pier Luigi , Stathis Anastasios , Carlo-Stella Carmelo , Lossos Izidore S. , Caimi Paolo F. , Han Sunwoo , Yang Fei , Kuker Russ A. , Moskowitz Craig H.
Published: January 2024

Kaplan-Meier curves for progression-free survival and overall survival by loncastuximab tesirine response.
Supplementary Figure S2 from PET/CT Biomarkers Enable Risk Stratification of Patients with Relapsed/Refractory Diffuse Large B-cell Lymphoma Enrolled in the LOTIS-2 Clinical Trial
Authors: Alderuccio Juan Pablo , Reis Isildinha M. , Hamadani Mehdi , Nachiappan Muthiah , Leslom Salman , Kahl Brad S. , Ai Weiyun Z. , Radford John , Solh Melhem , Ardeshna Kirit M. , Hess Brian T. , Lunning Matthew A. , Zinzani Pier Luigi , Stathis Anastasios , Carlo-Stella Carmelo , Lossos Izidore S. , Caimi Paolo F. , Han Sunwoo , Yang Fei , Kuker Russ A. , Moskowitz Craig H.
Published: January 2024

Correlation of metabolic tumor volume (MTV) calculations between two readers.
Supplementary Table S9 from Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of AGS15E Monotherapy in Patients with Metastatic Urothelial Carcinoma
Authors: Petrylak Daniel P. , Eigl Bernhard J. , George Saby , Heath Elisabeth I. , Hotte Sebastien J. , Chism David D. , Nabell Lisle M. , Picus Joel , Cheng Susanna Y. , Appleman Leonard J. , Sonpavde Guru P. , Morgans Alicia K. , Pourhosseini Pourya , Wu Ruishan , Standley Laura , Croitoru Ruslan , Yu Evan Y.
Published: January 2024

Supplementary Table S9. Serum PK Parameters of TAb at Cycle 1, Day 1, PK Analysis Set
Supplementary Table S6 from Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of AGS15E Monotherapy in Patients with Metastatic Urothelial Carcinoma
Authors: Petrylak Daniel P. , Eigl Bernhard J. , George Saby , Heath Elisabeth I. , Hotte Sebastien J. , Chism David D. , Nabell Lisle M. , Picus Joel , Cheng Susanna Y. , Appleman Leonard J. , Sonpavde Guru P. , Morgans Alicia K. , Pourhosseini Pourya , Wu Ruishan , Standley Laura , Croitoru Ruslan , Yu Evan Y.
Published: January 2024

Supplementary Table S6. Serum PK Parameters of AGS15E ADC at Cycle 1, Day 15, PK Analysis Set