bluuebunny/crossref_metadata_2025 huggingface dataset:
Cardiovascular progenitor cells cultured aboard the International Space Station exhibit altered developmental and functional properties
Authors: Baio Jonathan , Martinez Aida F. , Silva Ivan , Hoehn Carla V. , Countryman Stephanie , Bailey Leonard , Hasaniya Nahidh , Pecaut Michael J. , Kearns-Jonker Mary
Published: July 2018

The heart and its cellular components are profoundly altered by missions to space and injury on Earth. Further research, however, is needed to characterize and address the molecular substrates of such changes. For this reason, neonatal and adult human cardiovascular progenitor cells (CPCs) were cultured aboard the International Space Station. Upon return to Earth, we measured changes in the expression of microRNAs and of genes related to mechanotransduction, cardiogenesis, cell cycling, DNA repair, and paracrine signaling. We additionally assessed endothelial-like tube formation, cell cycling, and migratory capacity of CPCs. Changes in microRNA expression were predicted to target extracellular matrix interactions and Hippo signaling in both neonatal and adult CPCs. Genes related to mechanotransduction (YAP1, RHOA) were downregulated, while the expression of cytoskeletal genes (VIM, NES, DES, LMNB2, LMNA), non-canonical Wnt ligands (WNT5A, WNT9A), and Wnt/calcium signaling molecules (PLCG1, PRKCA) was significantly elevated in neonatal CPCs. Increased mesendodermal gene expression along with decreased expression of mesodermal derivative markers (TNNT2, VWF, and RUNX2), reduced readiness to form endothelial-like tubes, and elevated expression of Bmp and Tbx genes, were observed in neonatal CPCs. Both neonatal and adult CPCs exhibited increased expression of DNA repair genes and paracrine factors, which was supported by enhanced migration. While spaceflight affects cytoskeletal organization and migration in neonatal and adult CPCs, only neonatal CPCs experienced increased expression of early developmental markers and an enhanced proliferative potential. Efforts to recapitulate the effects of spaceflight on Earth by regulating processes described herein may be a promising avenue for cardiac repair.
Author Correction: Plasmonic Chromatic Electrode with Low Resistivity
Authors: Moon Young Gyu , Do Yun Seon , Lee Min Ho , Hwang Bo Yeon , Jeong Dong Jun , Ju Byeong-Kwon , Choi Kyung Cheol
Published: July 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Author Correction: Tailoring the structural, morphological, optical and dielectric properties of lead iodide through Nd3+ doping
Authors: Shkir Mohd. , AlFaify S.
Published: July 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Publisher Correction: Effects of water level regulation on the seed germination and production of annual plant Xanthium sibiricum in the water-level-fluctuating-zone of Three Gorges Reservoir
Authors: Liu Jianhui , Lin Feng , Shi Shaohua , Ayi Qiaoli , Liu Songping , Zeng Bo
Published: July 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
The Roles of Serotonin in Decision-making under Social Group Conditions
Authors: Lee Young-A , Goto Yukiori
Published: July 2018

People in a social group often have to make decisions under conflict, for instance, to conform to the group or obey authority (subjects at higher social rank in the group). The neural mechanisms underlying how social group setting affects decision-making have largely remained unclear. In this study, we designed novel behavioral tests using food access priority and fear conditioning paradigms that captured decision-making under conflict associated with social group environments in mice and examined the roles of serotonin (5-HT) on these processes. Using these behavioral tests, administration of the selective 5-HT reuptake inhibitor, which increased 5-HT transmission, was found to attenuate conflicts in decision-making that may be associated with human cases of social obedience and conformity in mice under group housing. The results suggest that 5-HT plays important roles in the regulation of individual behaviors that organize social group dynamics.
Propolis potentiates the effect of cranberry (Vaccinium macrocarpon) against the virulence of uropathogenic Escherichia coli
Authors: Ranfaing Jérémy , Dunyach-Remy Catherine , Louis Laurence , Lavigne Jean-Philippe , Sotto Albert
Published: July 2018

Uropathogenic Escherichia coli (UPEC), the most prevalent bacteria isolated in urinary tract infections (UTI), is now frequently resistant to antibiotics used to treat this pathology. The antibacterial properties of cranberry and propolis could reduce the frequency of UTIs and thus the use of antibiotics, helping in the fight against the emergence of antibiotic resistance. Transcriptomic profiles of a clinical UPEC strain exposed to cranberry proanthocyanidins alone (190 µg/mL), propolis alone (102.4 µg/mL) and a combination of both were determined. Cranberry alone, but more so cranberry + propolis combined, modified the expression of genes involved in different essential pathways: down-expression of genes involved in adhesion, motility, and biofilm formation, and up-regulation of genes involved in iron metabolism and stress response. Phenotypic assays confirmed the decrease of motility (swarming and swimming) and biofilm formation (early formation and formed biofilm). This study showed for the first time that propolis potentiated the effect of cranberry proanthocyanidins on adhesion, motility, biofilm formation, iron metabolism and stress response of UPEC. Cranberry + propolis treatment could represent an interesting new strategy to prevent recurrent UTI.
Tescalcin/c-Src/IGF1Rβ-mediated STAT3 activation enhances cancer stemness and radioresistant properties through ALDH1
Authors: Lee Jei Ha , Choi Soo Im , Kim Rae Kwon , Cho Eun Wie , Kim In Gyu
Published: July 2018

Tescalcin (TESC; also known as calcineurin B homologous protein 3, CHP3) has recently reported as a regulator of cancer progression. Here, we showed that the elevation of TESC in non-small cell lung cancer (NSCLC) intensifies epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) properties, consequently enhancing the cellular resistance to γ-radiation. TESC expression and the phosphorylation (consequent activation) of signal transducer and activator of transcription 3 (STAT3) were upregulated in CSC-like ALDH1high cells than in ALDH1low cells sorted from A549 NSCLC cells. Knockdown of TESC suppressed CSC-like properties as well as STAT3 activation through inhibition of insulin-like growth factor 1 receptor (IGF1R), a major signaling pathway of lung cancer stem cells. TESC activated IGF1R by the direct recruitment of proto-oncogene tyrosine kinase c-Src (c-Src) to IGF1Rβ complex. Treatment of IGF1R inhibitor, AG1024, also suppressed c-Src activation, implicating that TESC mediates the mutual activation of c-Src and IGF1R. STAT3 activation by TESC/c-Src/IGF1R signaling pathway subsequently upregulated ALDH1 expression, which enhanced EMT-associated CSC-like properties. Chromatin immunoprecipitation and luciferase assay demonstrated that STAT3 is a potential transcription activator of ALDH1 isozymes. Ultimately, targeting TESC can be a potential strategy to overcome therapeutic resistance in NSCLC caused by augmented EMT and self-renewal capacity.
Generalized lattice Wilson–Dirac fermions in (1 + 1) dimensions for atomic quantum simulation and topological phases
Authors: Kuno Yoshihito , Ichinose Ikuo , Takahashi Yoshiro
Published: July 2018

The Dirac fermion is an important fundamental particle appearing in high-energy physics and topological insulator physics. In particular, a Dirac fermion in a one-dimensional lattice system exhibits the essential properties of topological physics. However, the system has not been quantum simulated in experiments yet. Herein, we propose a one-dimensional generalized lattice Wilson-Dirac fermion model and study its topological phase structure. We show the experimental setups of an atomic quantum simulator for the model, in which two parallel optical lattices with the same tilt for trapping cold fermion atoms and a laser-assisted hopping scheme are used. Interestingly, we find that the model exhibits nontrivial topological phases characterized by gapless edge modes and a finite winding number in the broad regime of the parameter space. Some of the phase diagrams closely resemble those of the Haldane model. We also discuss topological charge pumping and a lattice Gross-Neveu model in the system of generalized Wilson-Dirac fermions.
Transcriptome sequencing and molecular markers discovery in the gonads of Portunus sanguinolentus
Authors: Zhang Yin , Miao Guidong , Wu Qingyang , Lin Fan , You Cuihong , Wang Shuqi , Aweya Jude Juventus , Ma Hongyu
Published: July 2018

Crab culture has gained prominence in the last decade due to the large global market demand for live crabs and crab products. Portunus sanguinolentus is one of the economically important crab species in the Indo-Pacific region, with distinct differences in growth and size between male and female crabs, thus, leading to huge difference in their market values. The culture of P. sanguinolentus is still in its infancy, with crab supplies heavily dependent on wild catch. In order to unravel the molecular differences between male and female crabs, we generated a comprehensive transcriptomic dataset for P. sanguinolentus by sequencing the gonads of both sexes using the Illumina Hiseq 2500 system. Transcriptomes were assembled using Trinity de novo assembly followed by annotation. This transcriptomic data set for P. sanguinolentus would serve as an important reference data for genomic and genetic studies in this crab and related species.
Partial least squares structural equation modeling of chemistry attitude in introductory college chemistry
Authors: Ross James , Nuñez Leslie , Lai Chinh Chu
Published: July 2018

Students’ decisions to enter or persist in STEM courses is linked with their affective domain. The influence of factors impacting students’ affective domain in introductory college chemistry classes, such as attitude, is often overlooked by instructors, who instead focus on students’ mathematical abilities as sole predictors of academic achievement. The current academic barrier to enrollment in introductory college chemistry classes is typically a passing grade in a mathematics prerequisite class. However, mathematical ability is only a piece of the puzzle in predicting preparedness for college chemistry. Herein, students’ attitude toward the subject of chemistry was measured using the original Attitudes toward the Subject of Chemistry Inventory (ASCI). Partial least squares structural equation modeling (PLS-SEM) was used to chart and monitor the development of students’ attitude toward the subject of chemistry during an introductory college chemistry course. Results from PLS-SEM support a 3-factor (intellectual accessibility,emotional satisfaction, andinterestandutility) structure, which could signal the distinct cognitive, affective, and behavioral components of attitude, according to its theoretical tripartite framework. Evidence of a low-involvement hierarchy of attitude effect is also presented herein. This study provides a pathway for instructors to identify at-risk students, exhibiting low affective characteristics, early in a course so that academic interventions are feasible. The results presented here have implications for the design and implementation of teaching strategies geared toward optimizing student achievement in introductory college chemistry.
Single sensors for multiple analytes employing fluorometric differentiation for Cr3+ and Al3+ in semi-aqueous medium with bio-activity and theoretical aspects
Authors: Dolai Malay , Saha Urmila , Das Avijit Kumar , Suresh Kumar Gopinatha
Published: July 2018

A Schiff base ligand (H2SALNN) exhibits turn-on fluorescence for Al3+ and Cr3+ at two distinct wavelengths via restricted CN isomerization and CHEF.
Two-dimensional self-assembled nanostructures of nucleobases and their related derivatives on Au(111)
Authors: Ding Yuanqi , Wang Xinyi , Xie Lei , Yao Xinyi , Xu Wei
Published: July 2018

Two-dimensional self-assembled nanostructures can be constructed by nucleobases and various reactants on Au(111).
Photocatalytic H2production by dirhodium(ii,ii) photosensitizers with red light
Authors: Sayre Hannah J. , Millet Agustin , Dunbar Kim R. , Turro Claudia
Published: July 2018

Photocatalytic H2evolution uponλirr= 655 nm with dirhodium(ii,ii) photosensitizers demonstrates tunable oxidative and reductive quenching mechanisms.
Chemical andin silicotuning of the magnetisation reversal barrier in pentagonal bipyramidal Dy(iii) single-ion magnets
Authors: Canaj Angelos B. , Singh Mukesh Kumar , Wilson Claire , Rajaraman Gopalan , Murrie Mark
Published: July 2018

New air-stable axial Dy(iii) complexes show magnetic hysteresis up to 10 K, whilein silicogenerated model complexes reveal the importance of outer-sphere interactions in controlling the magnetisation reversal barrier.
Sensitive and label-free discrimination of 5-hydroxymethylcytosine and 5-methylcytosine in DNA by ligation-mediated rolling circle amplification
Authors: Wang Zi-yue , Wang Meng , Zhang Yan , Zhang Chun-yang
Published: July 2018

We develop a label-free fluorescence method for sensitive discrimination of 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC) by ligation-mediated rolling circle amplification.
Three-dimensional layered double hydroxide membranes: fabrication technique, growth mechanism, and enhanced photocatalytic activity
Authors: Xue Li , Lü Zhipeng , Cheng Yingzhi , Sun Xiuyu , Lin Hongtao , Xiao Xiaoling , Liu Xiangfeng , Zhuo Shuping
Published: July 2018

Novel three-dimensional ZnAl–LDH/AAO and NiAl–LDH/AAO membranes using porous anodic aluminum oxide (AAO) templates as a substrate and an Al3+ source were successfully fabricated via a simple precipitant-free in situ growth technique.
“Calix[4]-box” cages promote the formation of amide bonds in water in the absence of coupling reagents
Authors: Feng Wei-Xu , Dai Liya , Zheng Shao-Ping , van der Lee Arie , Su Cheng-Yong , Barboiu Mihail
Published: July 2018

Calix[4]box cages promote template synthesis via accelerated amide bond formation upon encapsulation in water.
DNA logic assembly powered by a triplex-helix molecular switch for extracellular pH imaging
Authors: Qi Hongjie , Yue Shuzhen , Bi Sai , Ding Caifeng , Song Weiling
Published: July 2018

A strategy is rationally designed to finely control the hybridization chain reaction (HCR) for the self-assembly of DNA nanostructures by simply changing the pH, which is successfully applied to molecular logic operations and extracellular pH imaging.
A squaramide-based metal–organic framework as a luminescent sensor for the detection of lactose in aqueous solution and in milk
Authors: Jiang Min , Li Pingping , Wu Pengyan , Zhang Fengjie , Tian Xueqing , Deng Chaofan , Wang Jian
Published: July 2018

A squaramide-containing luminescent metal–organic framework represents the first example of MOF-implicated sensors for lactose in aqueous solution and in milk.
Supramolecular nanoparticles based on β-CD modified hyaluronic acid for DNA encapsulation and controlled release
Authors: Yang Yang , Jia Xin , Zhang Ying-Ming , Li Nan , Liu Yu
Published: July 2018

Supramolecular nanoparticles composed of doubly positively charged adamantane (ADA2+) and β-CD modified hyaluronic acid (HACD) were constructed and the controlled binding and release of pDNA was realized.
Synthesis of one-dimensional Bi2O3–Bi5O7I heterojunctions with high interface quality
Authors: Peng Yin , Mao Yan Ge , Liu Ting
Published: July 2018

One-dimensional Bi2O3–Bi5O7I heterostructures with high interface quality were first synthesized by calcining of BiOI–Bi(OHC2O4)·2H2O precursors. And the obtained Bi2O3–Bi5O7I heterostructures exhibit outstanding photocatalytic activity for degrading methyl orange and phenol with high concentration.
Direct growth of lithium magnesium silicate nanotubes on a glass slide
Authors: Hai Chunxi , Zhou Yuan , Wang Feng , Fuji Masayoshi
Published: July 2018

A novel, facile, one-step hydrothermal method for the direct growth of lithium magnesium silicate (hectorite) nanotubes on a silicate glass slide has been developed.
Combining complexing agent and solvothermal reaction for the morphology controlled synthesis of (Y,Eu)PO4crystals with size-dependent photoluminescence
Authors: Wang Zhihao , Wang Xuejiao , Takei Toshiaki , Zhu Qi , Kim Byung-Nam , Li Ji-Guang
Published: July 2018

An organic additive assisted solvothermal reaction has led to the phase/morphology controlled synthesis of YPO4crystals, whose size-dependent luminescence was also investigated.
Photoelectron shake-ups as a probe of molecular symmetry: 4d XPS analysis of I3− in solution
Authors: Norell Jesper , Grell Gilbert , Kühn Oliver , Odelius Michael , Bokarev Sergey I.
Published: July 2018

Accurate XPS simulations reveals the connection between solvent-induced nuclear asymmetry and shake-up intensity in the 4d spectra of I3−.
Brightly luminescent and color-tunable green-violet-emitting halide perovskite CH3NH3PbBr3 colloidal quantum dots: an alternative to lighting and display technology
Authors: Liu Yonghao , Xu Quan , Chang Shuai , Lv Zhao , Huang Sheng , Jiang Feng , Zhang Xin , Yang Gaoling , Tong Xin , Hao Shujuan , Ren Yandong
Published: July 2018

Organic–inorganic hybrid perovskite (CH3NH3PbX3, X = Cl, Br, or I) quantum dots have become one of the most promising materials for optoelectronic applications.
Inducing regioselective chemical reactivity in graphene with alkali metal intercalation
Authors: Mitchell Izaac , Irle Stephan , Page Alister J.
Published: July 2018

Intercalating alkali metal atoms between metal substrates and adsorbed graphene monolayers yields curvature-induced regioselective reactivity of graphene.
Prediction of DNA and RNA structure with the NARES-2P force field and conformational space annealing
Authors: Sieradzan Adam K. , Golon Łukasz , Liwo Adam
Published: July 2018

A physics-based method for the prediction of the structures of nucleic acids, which is based on the physics-based 2-bead NARES-2P model of polynucleotides and global-optimization Conformational Space Annealing (CSA) algorithm has been proposed.
Understanding mode-specific dynamics in the local mode representation
Authors: Song Hongwei , Yang Minghui
Published: July 2018

Local mode representation provides a new perspective to understand reaction dynamics of elementary chemical reactions.
Sublimation thermodynamics aspects of adamantane and memantine derivatives of sulfonamide molecular crystals
Authors: Perlovich German L. , Volkova Tatyana V.
Published: July 2018

The sublimation thermodynamics and thermophysical properties of crystals based on adamantane and memantine structural moieties were studied and the relationship between the noted parameters and the crystal structure descriptors was found.
2D library beyond graphene and transition metal dichalcogenides: a focus on photodetection
Authors: Wang Feng , Wang Zhenxing , Yin Lei , Cheng Ruiqing , Wang Junjun , Wen Yao , Shifa Tofik Ahmed , Wang Fengmei , Zhang Yu , Zhan Xueying , He Jun
Published: July 2018

Two-dimensional materials beyond graphene and TMDs can be promising candidates for wide-spectra photodetection.
Nitrogen-doped graphene-like carbon nanosheets from commercial glue: morphology, phase evolution and Li-ion battery performance
Authors: Damodar D. , Kumar S. Krishna , Martha S. K. , Deshpande A. S.
Published: July 2018

The morphology of nitrogen-doped graphene-like carbon nanosheets along with a proposed mechanism for ladder structure formation during carbonization of commercial glue.
Synthesis, characterization and application of organorhenium(vii) trioxides in metathesis reactions and epoxidation catalysis
Authors: Dyckhoff Florian , Li Su , Reich Robert M. , Hofmann Benjamin J. , Herdtweck Eberhardt , Kühn Fritz E.
Published: July 2018

Fluorinated (σ-aryl)trioxorhenium(vii) complexes have been shown to be active catalysts in epoxidation and metathesis reactions.
Lewis base complexes of sila[2]aluminocenophanes
Authors: Haider Wasim , Huch Volker , Schäfer André
Published: July 2018

Several new sila[2]aluminocenophane Lewis base complexes are described, which were synthesized directly from the corresponding sila[2]magnesocenophane and AlX3·base precursors by transmetalation.
Biocatalytic removal of perchlorate and nitrate in ion-exchange waste brine
Authors: Hutchison Justin M. , Zilles Julie L.
Published: July 2018

This work demonstrates biocatalytic reduction of perchlorate and nitrate in ion-exchange waste brines. Biocatalysis could allow regeneration of the brines and prevent reintroduction of these contaminants into the environment.
Green synthesized unmodified silver nanoparticles as a multi-sensor for Cr(iii) ions
Authors: Aravind Archana , Sebastian Maria , Mathew Beena
Published: July 2018

In this work we present optical, fluorescence and electrochemical sensing of Cr(iii) ions using silver nanoparticles (AgNPs) synthesized by a green method using Lycopersicon esculentum (LE) extract without any surface functionalization.
Correction: Hydrogenation of levoglucosenone to renewable chemicals
Authors: Krishna Siddarth H. , McClelland Daniel J. , Rashke Quinn A. , Dumesic James A. , Huber George W.
Published: July 2018

Correction for ‘Hydrogenation of levoglucosenone to renewable chemicals’ by Siddarth H. Krishna et al., Green Chem., 2017, 19, 1278–1285.
Design and fabrication of a liver-on-a-chip platform for convenient, highly efficient, and safein situperfusion culture of 3D hepatic spheroids
Authors: Ma Li-Dong , Wang Yi-Tong , Wang Jing-Rong , Wu Jian-Lin , Meng Xian-Sheng , Hu Ping , Mu Xuan , Liang Qiong-Lin , Luo Guo-An
Published: July 2018

This work presents a biomimetic and reversibly-assembled liver-on-a-chip platform for building a 3D liver spheroid model.
High-precision digital droplet pipetting enabled by a plug-and-play microfluidic pipetting chip
Authors: Mao Yuxin , Pan Yang , Li Xuan , Li Baoqing , Chu Jiaru , Pan Tingrui
Published: July 2018

A novel high-precision digital droplet pipetting method that is used for nanoliter liquid handling with a reversibly pluggable microfluidic pipetting chip.
The morphology-dependent electrocatalytic activities of spinel-cobalt oxide nanomaterials for direct hydrazine fuel cell application
Authors: Kumaran R. , Boopathi S. , Kundu M. , Sasidharan M. , Maduraiveeran G.
Published: July 2018

Morphologically-tuned spinel-cobalt oxide nanomaterials such as pellet-, flower-, cube- and sheet-like structures as an anode for an enhanced hydrazine oxidation reaction (HOR) is demonstrated.
A novel electrocatalytic nanocomposite of reduced graphene oxide/silver nanocube hybrid decorated imprinted polymer for ultra-trace sensing of temozolomide
Authors: Pathak Purnendu Kumar , Kumar Anil , Prasad Bhim Bali
Published: July 2018

A new nanocomposite of reduced graphene oxide/silver nanocube hybrid decorated molecularly imprinted polymer at the surface of a screen-printed carbon electrode was developed for the electroanalysis of an anticancerous drug, temozolomide, at the ultra-trace level.
Unique dual responsive activity of a platinum nanozyme stabilized by a green solvent: deep eutectic solvents
Authors: Devi Henam Sylvia , Singh Henam Premananda
Published: July 2018

A single pot cascade reaction revealed the natural uricase and peroxidase enzyme mimicking behaviours of Pt nanocubes.
Development of a selective and sensitive Ga3+ sensor for environmental safety: a comparative study of cyclohexyl and aromatic bis-sulphonamide fabricated glassy carbon electrodes
Authors: Sheikh Tahir Ali , Arshad Muhammad Nadeem , Asiri Abdullah M. , Rahman Mohammed M.
Published: July 2018

The aim of this study was to synthesize the new chelating agents CDBDMBS and PBDMBD for environmental remediation by sensing of Ga3+ in aqueous solution. The electrochemical technique is introduced a new approach of development of cost effective toxic cationic sensors for environmental and healthcare fields.
“Two channel” photocatalytic hydrogen peroxide production using g-C3N4coated CuO nanorod heterojunction catalysts preparedviaa novel molten salt-assisted microwave process
Authors: Bai Jin , Sun Yongzhen , Li Meiyuan , Yang Lina , Li Jian , Hu Shaozheng
Published: July 2018

This work reports g-C3N4coated CuO nanorod catalysts with outstanding photocatalytic H2O2production abilityviaa “two channel pathway”.
Design, synthesis, and phase behaviors of a novel triphenylene-based side chain liquid crystalline diblock copolymer
Authors: Ban Jianfeng , Pan Lulu , Shi Bo , Zhang Hailiang
Published: July 2018

Influence of the weight fraction of PMT6S on the phase behaviors of diblock copolymers.
A sensitive detection method of carcinoembryonic antigen based on dsDNA-templated copper nanoparticles
Authors: Chen Mingjian , Yeasmin Khusbu Farjana , Ma Changbei , Wu Kefeng , Zhao Han , Chen Hanchun , Wang Kemin
Published: July 2018

A label-free fluorescence assay has been developed for the detection of carcinoembryonic antigen based on dsDNA-templated copper nanoparticles.
Substrate-induced magnetism and topological phase transition in silicene
Authors: Yang Ke , Huang Wei-Qing , Hu Wangyu , Huang Gui-Fang , Wen Shuangchun
Published: July 2018

Silicene has shown great potential for applications as a versatile material in nanoelectronics and is particularly promising as a building block for spintronic applications.
Highly efficient Pb(ii) and Cu(ii) removal using hollow Fe3O4@PDA nanoparticles with excellent application capability and reusability
Authors: Wang Ning , Yang Dongxu , Wang Xiangxue , Yu Shujun , Wang Hongqing , Wen Tao , Song Gang , Yu Zhimin , Wang Xiangke
Published: July 2018

The easily synthesized Fe3O4@PDA material showed excellent performance for Pb(ii) and Cu(ii) elimination from wastewater, and its adsorption mechanism was revealed.
Role of enhanced solubility in esterification of 2,5-furandicarboxylic acid with ethylene glycol at reduced temperatures: energy efficient synthesis of poly(ethylene 2,5-furandicarboxylate)
Authors: Joshi Anup S. , Alipourasiabi Niloofar , Kim Yong-Wah , Coleman Maria R. , Lawrence Joseph G.
Published: July 2018

The enhanced solubility of 2,5-furandicarboxylic acid in ethylene glycol results in faster kinetics at lower temperatures compared to conventional reaction temperatures for polyesters.
Postgraduate students' attitudes towards group work: experiences within a forensic chemistry programme
Authors: Hamnett Hilary J. , McKie Amanda E. , Morrison Calum
Published: July 2018

The ability to work in a group is an important skill for graduates. Although the experiences of undergraduate students with group work have been extensively explored, there is much less information in the literature regarding postgraduate students and no information on those enrolled in science programmes. In this study, participants from a taught applied chemistry postgraduate MSc programme report their attitudes and experiences with group work. The usefulness of this approach and of scientific discourse for learning and teaching several key concepts is also explored. Participants in the study completed attitudinal questionnaires and group/individual multiple choice question (MCQ) tests. They reported a range of skills developed through working together, mixed preferences for groupvs.individual assignments, and comparison of the mean MCQ test scores between participants working individually and in groups demonstrated no statistically significant differences.
A highly site-selective radical sp3 C–H amination of azaheterocycles
Authors: Bentley Keith W. , Dummit Krysta A. , Van Humbeck Jeffrey F.
Published: July 2018

This report describes the development of a novel C–H amination strategy using both a Cu(ii) Lewis acid and an organic hydrogen atom transfer catalyst to activate benzylic C–H bonds adjacent to aromatic N-heterocycles.
Comprehensive insights into cellulose structure evolution via multi-perspective analysis during a slow pyrolysis process
Authors: Liang Jiajin , Chen Jiao , Wu Shubin , Liu Chao , Lei Ming
Published: July 2018

Multi-perspective analysis of cellulose structure evolution in a slow pyrolysis process developed a comprehensive understanding of the cellulose pyrolysis mechanism.
Antimony-doped Bi0.5Sr0.5FeO3−δ as a novel Fe-based oxygen reduction electrocatalyst for solid oxide fuel cells below 600 °C
Authors: Gao Lei , Li Qiang , Sun Liping , Xia Tian , Huo Lihua , Zhao Hui , Grenier Jean-Claude
Published: July 2018

The perovskite oxide Bi0.5Sr0.5Fe0.90Sb0.10O3−δ exhibits good structure stability and superior electrocatalytic activity for the oxygen reduction reaction, making it a highly promising cathode for LT-SOFCs.
The effect of different hydroxyapatite microparticles on the osteogenic differentiation of MC3T3-E1 preosteoblasts
Authors: Xu Wei , Xu Chao , Yi Jiling , Dai Honglian
Published: July 2018

HA microparticles with different sizes and shapes played obvious different roles in promoting the osteogenic differentiation of MC3T3-E1 preosteoblasts. HA microspheres played a better role in promoting the osteogenic differentiation of MC3T3-E1 preosteoblasts than HA whiskers.
In vitroandin vivotoxicity evaluation of halloysite nanotubes
Authors: Long Zheru , Wu Yan-Ping , Gao Hua-Ying , Zhang Jun , Ou Xianfeng , He Rong-Rong , Liu Mingxian
Published: July 2018

Halloysite is weakly toxic to cells and can be excreted out through the gastrointestinal metabolism of zebrafish.
Nanostructured interfaces for probing and facilitating extracellular electron transfer
Authors: Hsu Leo (Huan-Hsuan) , Deng Pu , Zhang Yixin , Nguyen Han N. , Jiang Xiaocheng
Published: July 2018

Probing and facilitating microbial extracellular electron transfer through nanotechnology enabled platforms are transforming bioenergetic, bioelectronic, and other related research areas.
Ligand-free synthesis of gold nanoparticles incorporated within cylindrical block copolymer films
Authors: Aubrit Florian , Testard Fabienne , Paquirissamy Aurélie , Gobeaux Frédéric , Wang Xuan , Nallet Frédéric , Fontaine Philippe , Ponsinet Virginie , Guenoun Patrick
Published: July 2018

Sonochemically produced gold nanoparticles are organized into oriented block copolymer cylinders to obtain anisotropic plasmonic nanocomposite films.
Correction: Novel insight into the structure and properties of lead-free dielectric Sr3TiNb4O15
Authors: Whittle Thomas A. , Brant William R. , Withers Ray L. , Liu Yun , Howard Christopher J. , Schmid Siegbert
Published: July 2018

Correction for ‘Novel insight into the structure and properties of lead-free dielectric Sr3TiNb4O15’ by Thomas A. Whittle et al., J. Mater. Chem. C, 2018, DOI: 10.1039/c8tc00732b.
Host galaxies of SNe Ic-BL with and without long gamma-ray bursts
Authors: Japelj J. , Vergani S. D. , Salvaterra R. , Renzo M. , Zapartas E. , de Mink S. E. , Kaper L. , Zibetti S.
Published: July 2018

Broad-line Ic supernovae (SNe Ic-BL) are a very rare class of core-collapse supernovae exhibiting high ejecta velocities and high kinetic energies. They are the only type of SNe that accompany long gamma-ray burst (GRB) explosions. Systematic differences found in the spectra of SNe Ic-BL with and without GRBs (GRB-SNe and SNe Ic-BL, respectively) could either be due to differences in the progenitor or/and explosion mechanism of SNe Ic-BL caused by the presence or absence of a GRB, or solely to differences in the viewing angle of the observer with respect to the orientation of the collimated explosion. We present the systematic comparison of the host galaxies of broad-lined SNe Ic with and without a detected GRB, the latter being detected in untargeted surveys, with the aim to find out whether there are any systematic differences between the environments in which these two classes of SNe preferentially explode. We study photometric properties of the host galaxies of a sample of 8 GRB-SNe and a sample of 28 SNe Ic-BL at z < 0.2. The two galaxy samples have indistinguishable luminosity and proper size distribution. We find indications that GRB-SNe on average occur closer to the centres of their host galaxies, that is, the samples have a different distribution of projected offsets, normalized by the galaxy sizes. In addition, we compare gas-phase metallicities of the GRB-SNe and SNe Ic-BL host samples and find that a larger fraction of super-solar metallicity hosts are found among the SNe Ic-BL without a GRB. Our results are indicative of a genuine difference between the two types of explosions and suggest that the viewing angle is not the main source of difference in the spectra of the two classes. We discuss the implications that our results have on our understanding of progenitors of SNe Ic-BL with and without a GRB.
Correlation Between Resistin Level and Metabolic Syndrome Component: A Review
Authors: Mostafazadeh Mostafa , Haiaty Sanya , Rastqar Ali , Keshvari Mahtab
Published: July 2018

Metabolic syndrome (MetS) has a collection of some abnormal and pathological conditions that cause many critical diseases. Resistin is one of the possible candidates for these pathologies but there are not enough data to prove if resistin has positive, neutral, or negative effects on one or some components of MetS. This review summarizes data about comparing the effects and contribution of resistin in initiation and progression of MetS components and also its different actions between human and other mammalians. This summarized data about the relationship of resistin and MetS components have been obtained from clinical researches and in some cases even animal studies. To find the relevant studies, the search in PubMed, Science Direct, and Scopus were performed. Human and animal studies on relationships between resistin and MetS (initiation and progression of components) were included in our search. In experiments reported among different human genetic groups as well as the patients with various disease such as diabetes, no significant correlation is shown between FBG and resistin level. Furthermore, this review shows that the results of correlation between resistin and TG, HDL, and central or abdominal obesity were inconsistent. These inconsistencies can arise from different sample size or genetic groups, gender, and also from experimental studies. Therefore, to obtain precise results systematic review and meta-analyses are required.
Die Bedeutung von Qualitätsmanagement in Rehabilitations-Einrichtungen aus Sicht von Qualitätsmanagement-Beauftragten
Authors: Spiegel Marco
Published: July 2018

Zielsetzung Ziel der Arbeit ist die Evaluation der Bedeutung von QM in Reha-Einrichtungen

Methodik Es wurden acht qualitative Interviews mit QMB aus ambulanten und stationären Einrichtungen im Raum Berlin und Brandenburg geführt. Die
systematische Auswertung der Interviews erfolgte mittels der qualitativen Inhaltsanalyse nach Mayring.

Ergebnisse Es zeigen sich Unterschiede hinsichtlich der Bedeutung des QM in ambulanten und stationären Einrichtungen. Für stationäre Einrichtungen ist QM
existentiell, wird aber dennoch nicht uneingeschränkt akzeptiert und in ambulanten Einrichtungen wird es sehr uneinheitlich angewendet und findet zum Teil keine
Anwendung.

Schlussfolgerungen Um die Bedeutung von QM zu erhöhen, muss es vereinfacht werden, damit allen Mitarbeiterinnen und Mitarbeiter ein Zugang ermöglicht
wird. Außerdem sollte QM fester Bestandteil in den Ausbildungen der Medizinfachberufe werden, damit Kenntnis über die Wirkmechanismen von QM besteht. Damit in
ambulanten Einrichtungen die Bedeutung von QM erhöht wird, sollte auch hier die Zertifizierungspflicht eingeführt werden.
Metal-free Deamidative Ugi Access to Isoindolinones
Authors: Hammal Lamouri , El Kaïm Laurent , Baaziz Samira , Kerim Mansour , Cordier Marie
Published: July 2018

A two-step isoindolone synthesis has been achieved by using an Ugi/oxidative vicarious nucleophilic substitution sequence starting from 3-nitrobenzoic acid and aromatic aldehydes. Loss of the amido group was observed as well as a further oxidative process towards hydroxyisoindolone derivatives after prolonged stirring open to the atmosphere.
First Synthesis of 2,9-Disubstituted cis-2,3a,7b,9,10a,14b-
Hexaazaperhydrodibenzotetracenes
Authors: Rakhimova Elena , Kirsanov Victor , Mescheryakova Ekaterina , Khalilov Leonard , Ibragimov Askhat , Dzhemilev Usein
Published: July 2018

The first synthesis of 2,9-disubstituted cis-2,3а,7b,9,10a,14b-hexaazaperhydrodibenzotetracenes has been accomplished through intermolecular heterocyclization of N,N-bis(methoxymethyl)alkylamines with cis-1,6,7,12-tetraazaperhydrotetracene in the presence of SmCl3·6H2O catalyst or by recyclization of 1,3,5-tricycloalkyl-1,3,5-triazinanes with cis-1,6,7,12-tetraazaperhydrotetracene in the presence of NiCl2·6H2O catalyst. The structures were established by 1D (1H, and 13C) and 2D (HSQC, HMBC, COSY, NOESY) NMR spectroscopy, MALDI TOF/TOF mass spectrometry, and X-ray diffraction analyses.
Timing and Course of Leucocyte Aggregation in Myocardial Infarction
Authors: Galante Alberto , Pietroiusti Antonio , Domenici Bruno , Magrini Andrea , Carta Sandro , Colace Francesco , Dell' Uomo Luigi , Cipriani Cesirio , Argiro Giovanni , Zulli Luigi , Giampaolo Martinelli
Published: July 2018

In order to evaluate the pathophysiological relevance and clinical implications of leukocyte rheology in myocardial ischaemia we measured the percentage of aggregated leukocytes in 43 subjects with acute substernal pain before diagnosis. The percentage of aggregated leukocytes was significantly higher in 16 patients with subsequent diagnosis of myocardial infarction with respect to 11 with angina and 16 with non ischaemic chest pain (4.75 ± 0.88, 3.43 ± 0.65 and 1.52 ±0.32 respectively p <0.01). The percentage of aggregated leukocytes was also evaluated in another group of 46 patients hospitalized for myocardial infarction. Among these, aggregated leukocytes were significantly higher in those with residual ischaemia, with respect to those without residual ischaemia (7.4 ± 1.1 vs 3.5 ±0.6, p <0.01).

In conclusion, leukocyte aggregation is precociously increased after myocardial ischaemia. It may be a marker of residual ischaemia in patients with myocardial infarction.
Chronic Hepatitis C Virus Infection in Haemophilic Patients: Clinical Significance of Viral Genotype
Authors: Telfer P T , Devereux H , Savage K , Scott F , Dhillon A P , Dusheiko G , Lee C A
Published: July 2018

We have undertaken a comprehensive study of hepatitis C virus (HCV) genotype and its clinical significance in haemophilic patients. 189 HCV RNA positive patients were typed, using the Simmonds classification scheme, by restriction fragment length polymorphism (RFLP) in an amplified segment of the 5 non-coding region of the HCV genome. Type 1 was found in 121 (64.0%), type 2 in 23 (12.2%), type 3 in 36 (19.0%), type 4 in 3 (1.6%), type 5 in 2 (1.1%) and mixed infection in 3 (1.6%). There were no type 6 infections and one patient (0.5%) could not be typed. Genotype was not associated with diagnosis, age, or with HIV infection. Type I was associated with higher serum HCV RNA levels, and with a poor response to interferon. Progression to hepatic decompensation has been seen less frequently in those with type 3 compared to type 1 infection (p = 0.07). Three out of eleven patients studied over a longer time course showed a change in genotype, the remainder were persistently infected with HCV type 1. In conclusion, HCV genotype has clinical relevance in the management of haemophilic patients. Those with type 1 are probably more likely to develop serious liver disease and since they respond poorly to inter- feron-α, should be considered for new treatment strategies aimed at sustained clearance of HCV RNA.
Production of Platelet-Activating Factor by Porcine Brain Microvascular Endothelial Cells in Culture
Authors: Satoh Kei , Yoshida Hidemi , Imalzumi Tada-Atsu , Koyama Masayuki , Takamatsu Shigeru
Published: July 2018

Endothelial cells produce platelet-activating factor (PAF), which is the key process in the interactions between the vascular wall and blood cells. To examine the production of PAF in brain microvasculature we have cultured brain endothelial cells and performed a comparative study with aortic endothelial cells. Fresh porcine brain was homogenized, and microvascular endothelial cells were separated by enzyme digestion. The cells were cultured in medium containing epidermal growth factor and bovine brain extract. Endothelial cells from the aorta of the same animal were cultured in a similar manner. Production of PAF was assessed by ǀ3Hǀacetate incorporation into phospholipids or by radioimmunoassay. Prostacyclin was measured by radioimmunoassay of 6-ketoprostaglandin F1α. The cells produced 1760 ± 403 and 2892 ± 347 dpm/106 cells (n = 4) of PAF when stimulated with brady- kinin and calcium ionophore A23187, each at 1 μM, respectively. Aortic endothelial cells produced 3911 ± 2006 and 8052 ± 2270 dpm/106 cells (n = 4), respectively, and these values were significantly higher than those in brain endothelial cells (p<0.01, U-test). Prostacyclin production was also higher in aortic cells as compared to brain microvascular endothelial cells. In aortic endothelial cells both Ca ionophore A23187 and bradykinin significantly stimulated PMN adherence whereas in brain microvascular cells only Ca ionophore enhanced the adherence. Brain microvascular endothelial cells produce smaller amount of PAF and prostacyclin as compared to aortic endothelial cells, and this fact may imply that the functional integrity of the brain microvascular endothelium is maintained at a low level.
Acadesine Reduces the Frequency of Coronary Artery Reocclusion Following rt-PA Induced Thrombolysis in the Dog
Authors: Young Mark A , Henry Christine , Wong Suzanna , Bullough David , Mullane Kevin
Published: July 2018

Acadesine is a ribose-substituted imidazole with antithrombotic properties mediated by adenosine. In view of the beneficial effects of antiplatelet agents on thrombolysis and post-thrombolytic reocclusion, we studied the effects of acadesine on t-PA induced coronary reperfusion and continued patency in anesthetized dogs with electrically-induced coronary artery thrombosis. In 4 groups of dogs we examined the effects of saline and 3 doses of acadesine (0.5,1.0,2.0 mg/kg/min, i.v.) on time to reperfusion, and incidence and time to reocclusion following infusion of t-PA (10 μg/kg/min, i.v.). Acadesine had no effect on time to reperfusion, but significantly (p <0.05) reduced the incidence of reocclusion and prolonged the time to reocclusion at the highest dose tested. In saline treated animals vessels reoccluded in 6 of 7 animals (86%) at 33 ± 6 min after reperfusion. With the lowest dose of acadesine (0.5 mg/kg/min) vessels reoccluded in 3 of 3 animals (100%) at 18 ± 7 min. In animals treated with 1.0 mg/kg/min acadesine, the incidence of reocclusion was reduced, but not significantly (p<0.1) to 2 of 6 (33%), and time to reocclusion was prolonged to 59 ± 11 min (p<0.1). At the highest dose (2.0 mg/kg/min) of acadesine, only 2 of 8 (25%) animals reoccluded (p<0.05), and time to occlusion was prolonged to 80 ± 13 min (p<0.05). Acadesine had no effect on hemodynamics. These results suggest that acadesine might prove beneficial in clinical settings of platelet activation and prothrombotic conditions, such as occur during thrombolysis with t-PA.
A Perspective on the Use of FVIII Concentrates and Cryoprecipitate Prophylactically in Surgery or Therapeutically in Severe Bleeds in Patients with von Willebrand Disease Unresponsive to DDAVP: Results of an International Survey
Authors: Foster Paul A
Published: July 2018

An international registry was established by the Subcommittee on von Willebrand Factor of the SSC/ISTH on the treatment of patients with types of von Willebrand disease (vWd) unresponsive to DDAVP infusion. Data was collected on 76 surgical events in 64 patients from 19 treatment centers. Thirty-three non-mucosal, 12 mucosal, 10 orthopedic and 21 dental procedures were reported. In the 76 surgical events, 14 cases prophylactically received cryoprecipitate while 62 received factor VIII (FVIII) concentrate. Surgical hemostasis was reported as satisfactory, good, or excellent in 75 of the 76 cases. Post-infusion bleeding times were measured in only three of 14 surgical events treated with cryoprecipitate. All three cases had a reduction but not correction of the bleeding time. The post-infusion bleeding time was measured in 27 of 62 cases in which FVIII concentrates were used. The bleeding time was normalized in 15, reduced but not normalized in eight, and not changed from baseline in four. Data was also collected from 16 treatment centers on 50 serious bleeding events in 35 patients. These included 19 gastrointestinal, 15 other mucosal, four central nervous system, seven orthopedic, and five other bleeds. Eleven cases received cryoprecipitate and 39 received FVIII concentrate as primary therapy. The efficacy of treatment was considered good or excellent in 49 of 50 cases. Post-infusion bleeding times were measured in only 15 of the 50 reported bleeding events. The post-infusion bleeding time was normalized in six, decreased but not normalized in eight, and not changed from baseline in one. In this retrospective survey, FVIII concentrates were subjectively as efficacious as cryoprecipitate in both the surgical setting and for the treatment of severe bleeds in patients with types of vWd unresponsive to DDAVP. Since the bleeding time was monitored during therapy in only a minority of these cases, a definitive relationship between the efficacy of therapy and normalization or reduction of the bleeding time in these two clinical settings cannot be established from this study. A prospective study on the use of FVIII and/or vWf concentrates in these clinical settings is necessary to address this issue.
Heterogenous Expression of Glycoprotein lb, IX and V in Platelets from Two Patients with Bernard-Soulier Syndrome Caused by Different Genetic Abnormalities
Authors: Noda Masaaki , Fujimura Kingo , Takafuta Toshiro , Shimomura Takeshi , Fujlmoto Tetsuro , Yamamoto Naomasa , Tanoue Kenjiro , Arai Morio , Suehiro Akira , Kakishita Eizo , Shimasaki Akemi , Kuramoto Atsushi
Published: July 2018

Bernard-Soulier syndrome (BSS) is a rare inherited bleeding disorder, which is caused by deficiency or decrease of the platelet GPIb/IX/V complex. Analysis of two patients with BSS by How cytometry of the blood revealed different expression patterns of the components of the GPIb/IX/V complex. In case 1, GPIX was completely absent but residual amounts of GPIbα and GPV were detectable; in case 2, GPIbα was completely absent. We amplified the coding regions of GPIbα, GPIbß, GPV, and GPIX from the patients’ genomic DNA with the polymerase chain reaction (PCR) and sequenced the PCR products. In case 1, we identified a point mutation in the GPIX coding region that changes the codon for tryptophan-126 (TGG) to a nonsense codon (TGA). In case 2, we found a deletion of nucleotide within seven adenine repeats at the position of 1932 to 1938 in the coding region of GPIbα, which causes a frame shift that results in 58 altered amino acids and a premature stop codon. These genetic changes alter the transmembrane domain of GPIX or GPIbα and, therefore, would prevent proper insertion of the proteins in the plasma membrane. Thus, abnormality of a single component protein (GPIX or GPIbα) alters the assembly of the GPIb/IX/V complex and causes heterogenous surface expression of GPIbα, GPV and GPIX.