bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinicoetiological profile, immediate outcome and short-term follow-up of term babies with hyperbilirubinemia
Authors: C. Sonika , D. Manoj , G. R. Basanth Kumar
Published: October 2018

Background: Neonatal jaundice is a common cause of admission of newborns. Since bilirubin is potentially toxic to the central nervous system, early detection and appropriate management is of paramount importance. We therefore undertook this study with an objective to assess the causes, clinical correlation, immediate outcome and short term follow up for hearing and neurodevelopmental assessment in term babies with jaundice admitted in our NICU.Methods: This study was done in NICU in Bapuji Child Health Institute and Research center attached to JJMMC, Davangere. This study included 100 term infants admitted for jaundice during November 2013 to May 2015 and 6 months follow up of these infants for hearing and neurodevelopmental outcome was done. A proforma was used to collect relevant information.Results: Physiological jaundice (50%) and Blood group incompatibility (36%) were the most common causes of hyperbilirubinemia in the study. During a short term follow up i.e. 6 months, majority (97%) of the jaundiced infants had normal hearing and neurodevelopmental outcome except for 3 infants who had sensorineural hearing loss and BIND. In severe group the percentage of abnormal BERA and unfavourable neurological outcome was more when compared to moderate group, which was statistically significant. All the 3 infants who had abnormal BERA had developmental delay.Conclusions: Neonatal jaundice is a common cause of admission of newborns. Physiological jaundice was the commonest cause of neonatal hyperbilirubinaemia followed by blood group incompatability. Majority of the infants had normal BERA and normal neurodevelopmental outcome on short term follow up. A close association was found between BERA and neurodevelopmental outcome in the study. BERA is an useful neurophysiological tool for monitoring neurological complications, however it is not a useful tool to predict final neurological outcome
Neurodevelopment and growth outcome at one year in babies born at term to mothers having pregnancy induced hypertension
Authors: Pagali Deepthi , Bollipo Suneetha , Natta Srinivasa Vithal Rao
Published: October 2018

Background: Hypertensive disorder in pregnancy remains an important cause of perinatal morbidity and mortality. Being small for gestational age (SGA) may be associated with poor neurodevelopmental outcomes compared to being appropriate for gestational age (AGA). The aim of this paper is to evaluate neurodevelopmental scores as well as growth monitoring in SGA and AGA infants born at term to PIH mothers followed till one year of age.Methods: This is a prospective, observational, hospital-based study, conducted in a tertiary care mother and child institute in Andhra Pradesh, South India.Results: Two hundred babies born at term to PIH mothers are included in the study and are followed up over a period of 12 months. Data is analyzed using Statistical Package for Social Sciences (SPSS). Growth retardation is seen in 12 % of term, SGA and 3.5% of term, AGA babies. SGA babies have a statistically significant correlation (p value = 0.02) in physical growth compared to AGA babies. Neurodevelopmental delay is present in 30% of SGA babies and 5% of AGA babies. The association between SGA and neurodevelopmental disability is statistically significant (p value <0.01).Conclusions: Pregnancy induced hypertension has a statistically significant effect on neurodevelopment and physical growth of a child when followed up to 12 months of age, in SGA babies, more so in VLBW babies. Early intervention programmes through medical, developmental, neuromotor, neurosensory interventions and other stimulation programs, might help in reducing the burden of the disease as well as improving the quality of life.
Clinical and bacteriological profile of neonatal sepsis with emerging resistance patterns
Authors: Rajana Rohitashwa , Bagri Dhan Raj , Sharma J. N. , Agrawal Vijay
Published: October 2018

Background: The present study was designed to evaluate the clinical spectrum, bacteriological profile, antibiotic sensitivity pattern and mortality due to neonatal septicemia in neonates admitted in neonatal units attached to the SMS Medical College, Jaipur.Methods: In born and out born babies of postnatal age up to 28 days who were bacteriological proven cases of septicemia were subjected to history, clinical examination and laboratory evaluation and data were analyzed statistically.Results: Out of 150 cases 67.33% neonates were preterm and 77.33% were low birth weight neonates. Gram negative organisms were most common cause of septicemia (66.6%), Both the Gram negative and Gram positive organisms were sensitive to piperacillin-tazobactam, linezolid, fosfomycin, teicoplanin, polymyxin B, colistin, ofloxacin. Both the Gram negative and Gram positive organisms were resistant against cephalosporins, ampicillin, Amoxyclav, cotrimoxazole. Gram negative isolates were most sensitive to Polymyxin B (70%) and had the highest resistance to cefepime (36%). Gram-positive organisms were most sensitive to vancomycin (84%) and linezolid (82%). Highest resistance was noted from Amoxyclav (52%).Conclusions: Preterm (<37 week) and low birth weight (<2500gm) neonates are considered as major susceptible causes of neonatal sepsis. Proper hygiene and hand washing, early detection of sepsis and judicial use of antibiotics to prevent multidrug resistance is needful in our setup.
Efficacy of zinc therapy in acute diarrhea in children
Authors: Chirla Suman , Datla Satish
Published: October 2018

Background: Diarrhoea is a major public health problem in developing countries. An estimate of 1.5 billion episodes of diarrhoea occurs each year and 3 million children under the age of 5 years die due to diarrhoea. Its effect is particularly devastating on children below 2 years of age, with eighty percent (80%) of deaths due to diarrhoea occurring during the first 2 years of life. Diarrhoeal diseases constitute 18% of under five deaths in Asia-Pacific countries.Methods: The present study was carried out in Anil Neerukonda hospital, Visakhapatnam from July’2015 to July’2017 over a period of 2 years. A detailed clinical study of 100 children between the age group of 6 months to 5 years with acute diorrhea was done. Zinc was given to 50% of cases and was not given to the rest of 50%. Duration of hospital stay (in days) and duration of diarrhoeal episodes (in days) were compared in both the groups.Results: Incidence of acute gastroenteritis was maximum below 2 years of age (77%). Patients administered with Zinc had significantly less duration of hospital stay 3.35 days vs. 5.34 days (in patients who were not administered zinc) with t=8.170 and a strongly significant p<0.001.Conclusions: Incidence of acute gastroenteritis is maximum below 2 years of age. Patients in zinc group had significantly less duration of hospital stay and less proportion diarrhoeal episodes on follow up compared to the non-zinc group.
Thyroid function test in nephrotic syndrome children who are admitted in emergency ward of Government Tirunelveli Medical College and Hospital, India
Authors: Rukmani J. , Krishanamurthy C. , Clarin Denny
Published: October 2018

Background: Nephrotic syndrome in childhood is largely primary or idiopathic, although a small proportion of cases are secondary to infectious agents and other glomerular and systemic diseases. The etiology of nephrotic syndrome is age-dependent. Most cases appearing in the first 3 months of life are referred as congenital nephrotic syndrome (CNS) and are due to genetic diseases. The objective of this study is to study the correlation between thyroid profile and different types of nephrotic syndrome.Methods: This cross-sectional study was done between March 2017 to October 2017 in the Department of Pediatrics Tirunelveli Government Medical College. 40 cases of nephrotic syndrome between 1 to12 years, which include all types of nephrotic syndrome. After history taking and clinical examination, blood samples were collected from the patients for thyroid function test and analyzed with standard techniques.Results: Serum T3, T4, TSH were found to be within normal limits. But TSH values in remission were significantly elevated compared to the first episode.Conclusions: Thyroid profiles in control were within normal range. The T4 and T3 levels in nephrotic syndrome were low and TSH was high. Hypothyroidism was more common in children less than 6 years.
Recurrent encephalopathy and hyperammonemia in new born: case of arginosuccinic aciduria
Authors: Singh Parminder , Gupta Divya
Published: October 2018

Urea cycle disorders result from defects in the metabolism of waste nitrogenous compounds derived from the breakdown of proteins and other nitrogen-containing molecules. Argininosuccinic aciduria is a rare autosomal recessive heterogeneous urea cycle disorder, which leads to the accumulation of argininosuccinic acid in the blood and urine. It is caused by defect in the argininosuccinate lyase (ASL) gene, which regulates the breakdown of argininosuccinate to fumarate and arginine in the urea cycle. They are a heterogeneous group of disorders which are associated with hyperammonemia resulting in severe neurological dysfunction like encephalopathy, seizures, developmental and psychomotor delay. The severe central nervous system dysfunction is by alteration of amino acid and neurotransmitters pathways and interference with normal cerebral energy metabolism and oxidative stress. Ammonium toxicity to the brain provokes irreversible damage due to cortical atrophy, edema, and demyelination, resulting in seizures, coma, and even death. We report such a case of urea cycle defect in a newborn that presented with recurrent encephalopathy with hyperammonemia precipitated by minor infections. Detailed investigations including genetic analysis lead to the diagnosis of argininosuccinic aciduria.
Rh-endostatin Concomitant with Chemotherapy Versus Single Agent Chemotherapy for Treating Soft Tissue and Bone Sarcomas: A Systematic Review and Meta-Analysis
Authors: Ma Zhuo , Guo Lifang , Cui Xiangli , Liu He , Liu Lihong
Published: October 2018

Objectives: Endostar (recombinant human endostatin (rh-endostatin)), a 20-kDa proteolytic fragment of collagen XVIII, was approved for the treatment of non–small cell lung cancer (NSCLC). Recently, several studies have evaluated the efficacy of rh-endostatin combined with chemotherapy in the treatment of bone and soft tissue sarcomas. Here, we conducted a systematic review and meta-analysis to assess available evidence. Methods: Pubmed, Embase, Web of Sciences, the Cochrane Library and two Chinese literature databases (CNKI, WanFang) were systematically searched till May 20, 2018. Randomized controlled trials (RCTs) and cohort studies which compared the outcomes of rh-endostatin combined with chemotherapy versus chemotherapy alone for treating bone sarcomas or soft tissue sarcomas were included. The primary outcome was overall survival rate (OSR). Secondary outcomes included objectiveremissionrate(ORR), clinical benefit rate (CBR), disease control rate (DCR), distant metastasis rate (DMR) and adverse effects (AEs). The methodological quality of the included studies was evaluated. Data analysis was performed by Revman 5.3 software. Results: 9 studies comprising 839 patients were included. The pooled results indicated that, compared with chemotherapeutic agents alone, rh-endostatin combined group had a significant benefit in 1-year and 2-year OSR. However, there were no difference between 5-year OSR. OR, CBR and DMR were higher in rh-endostatin combined group. No significant difference was observed in the incidence of AEs. Conclusions: Rh-endostatin combined chemotherapeutic agents significantly improved clinical efficacy compared with chemotherapeutic agents alone in treating bone and soft tissue sarcomas. Moreover, combination of rh-endostatin with chemotherapy didn’t increase the incidence of AEs. But more high quality RCTs with  large  sample  size  should  be  done  in  the  future  to confirm the conclusion.
Um Novo Retificador Trifásico Híbrido Multipulso com Elevado Fator de Potência
Authors: Freitas L.C. Gomes de , Coelho Ernane A. A. , Simões Marcelo G. , Canesin Carlos A. , Freitas Luiz Carlos de
Published: October 2018

Neste trabalho é proposto um novo retificador trifásico híbrido multipulsos, capaz de operar com elevado fator de potência (FP) e reduzida distorção harmônica total nas correntes de entrada (DHTI). O retificador híbrido proposto é composto por um retificador trifásico de 6 pulsos não-controlado (Ponte de Graetz), associado com conversores Boost monofásicos conectados em paralelo, em cada braço do retificador não-controlado. Esta estrutura é capaz de operar com uma forma de corrente CA (Corrente Alternada) de alimentação imposta, proporcionando elevado fator de potência e reduzida distorção harmônica total. Com o objetivo de comprovar as vantagens do retificador híbrido proposto, este artigo descreve seus princípios de operação, apresenta resultados experimentais detalhados e discussões a respeito do percentual de potência processada pelos conversores Boost, em relação à potência total de saída. Demonstra-se que apenas uma pequena fração da potência total de saída é processada pelos retificadores controlados, o que torna a estrutura proposta economicamente viável para aplicações de elevada potência, com um rápido retorno do investimento. Além disso, sua aplicação em grupos retificadores trifásicos não-controlados já existentes é perfeitamente possível, uma vez que os retificadores controlados podem ser facilmente integrados à estrutura. Os resultados de um protótipo de 6 kW, implementado em laboratório, e suas análises, demonstram a aplicabilidade da estrutura proposta para instalações de elevada potência.
New Synchronization Method For Three-phase Three-wire Pwm Converters Under Unbalanced And Distorted Grid Voltages
Authors: De Camargo Robinson F. , Pinheiro Humberto
Published: October 2018

This paper proposes a new open-loop synchronization method for three-phase three-wire PWM converters connected to the utility grid. It presents a good performance under unbalanced and highly distorted grid voltages. Moreover, it has a better performance in terms of distortions in the synchronization signals if compared with other open-loop methods and it has a good transient performance due amplitude, frequency and angle disturbances. In addition, a frequency adaptation algorithm is proposed for applications where large frequency variations are expected, such as in weak grids. Experimental results using a DSP TMS320F2812 are given to demonstrate the good performance of the proposed synchronization method.
Sistema De Filtragem Ativa Com Inversor Multinível Assimétrico Em Cascata De Dezenove Níveis E Controle De Tensão Nos Barramentos Cc
Authors: Silva Leonardo de Araújo , Pimentel Sérgio Pires , Pomilio José Antenor
Published: October 2018

Este artigo apresenta a implementação de um filtro ativo paralelo baseada no Conversor Multinível em Cascata Assimétrico. No esquema de controle proposto neste artigo, além de não serem necessárias fontes de tensão CC isoladas para manter constantes e balanceadas as tensões nos barramentos CC, não há a necessidade de transformadores para acoplamento com a rede. Com isso elimina-se a principal desvantagem do conversor que é requerer fontes de tensão CC isoladas com capacidade de operação em dois quadrantes ou que o acoplamento com a rede seja feito através de transformadores especiais. Um procedimento de précarga dos capacitores, necessário para evitar transitórios iniciais indesejáveis, também é discutido. Resultados experimentais são apresentados para validar o esquema proposto.
Sistema Distribuído De Geração Elétrica Com Um Gerador De Indução Trifásico Interligado Com Uma Rede Monofásica
Authors: Brandão Jacobina Cursino , Cipriano dos Santos Júnior Euzeli , Beltrão de Rossiter Corrêa Maurício , Roberto Cabral da Silva Edison
Published: October 2018

Este artigo propõe um sistema distribuído de geração de energia elétrica, composto de um gerador de indução e uma máquina primária, interligados com uma rede monofásica por meio de um conversor ca-ca de quatro braços para alimentação de cargas trifásicas. Fontes de energia eólica ou hidráulica podem ser usadas como acionador primário do gerador de indução. O artigo apresenta o princípio de funcionamento, o modelo e a estratégia de controle completa do sistema. A estratégia de controle proposta, incluindo o PWM, permite utilizar o conversor de quatro braços com a mesma tensão de barramento do conversor em ponte completa de cinco braços. Resultados de simulação e experimentais são apresentados.
Análise Crítica De Dispositivos Estáticos De Compensação Série De Baixa Tensão Com Transformadores Shunt: Custos Versus Funcionalidade
Authors: Lopes Bruno Marciano , Silva Sidelmo M. , Cardoso Filho Braz J. , Brito José A. S. , Travassos Gustavo
Published: October 2018

Compensadores série têm sido propostos e utilizados com sucesso na proteção de cargas sensíveis contra variações momentâneas de tensão, especialmente em aplicações de média e alta potência. O objetivo deste estudo é avaliar o impacto das especificações do compensador série, tais como profundidade e duração dos afundamentos compensados e capacidade de regular a tensão da carga, nos custos e volume deste. Inicialmente, é realizada uma discussão a respeito da intensidade e freqüência dos eventos de qualidade de energia e dos prejuízos a estes associados. Técnicas de projeto de conversores são apresentadas, ressaltando-se particularidades do projeto para operações de curta duração. Tais técnicas são utilizadas em dois projetos, cujas características das cargas são iguais, mas a capacidade de compensação dos dispositivos é distinta, de modo a se avaliar as diferenças em custo, peso e volume dos equipamentos, fornecendo critérios para uma análise objetiva da relação entre custos e funcionalidade.
Examining the Guidance and Counselling Studentsâ€™ Perceptions about English Language Learning Beliefs
Authors: Kaymakamoglu Sibel Ersel
Published: October 2018

Abstract

Since contemporary views of learning and teaching place learners in the center of learning process, most of the researchers and practitioners have directed their attention to understanding what goes on in the mind of the learners during the process of learning and teaching. In the area of English language learning and teaching this perspective have also been adopted and for more than three decades one of the main concerns of the researchers and practitioners have been on exploring the factors influencing the language learners in the learning and teaching process. â€˜Learner beliefsâ€™ have been identified as one of the main the sources of learnersâ€™ actions and decisions in this process. Therefore, in this study the researcher aimed to explore the English language learning beliefs of the students studying in the Guidance and Counseling Department at one of the Universities in Northern Cyprus. It also investigated whether there were any differences in the student teachersâ€™ perceptions about English language learning regarding gender and age. 132 first year student teachers studying in the Department of Guidance and Counseling Department at a University in North Cyprus were the participants of the study. 65 female and 67 male student teachers participated in this investigation. In order to collect data about the student teachersâ€™ perceptions regarding English language learning â€œEnglish Language Learning Beliefs Inventory (BALLI)â€ version 2 (Horwitz, 2013) was utilized. The questionnaire consisted of 44 items and the participants replied to each item according to the 5-point Likert Scale. The findings revealed that there were significant differences between the male and female participantsâ€™ perceptions about English language learning beliefs. The participant student teachersâ€™ perceptions about language learning beliefs differed significantly in relation to age.

Key words: Learner beliefs, gender, age, learning and teaching.
Examining the game teaching in special education teacher training in Turkey and European Union Member States
Authors: Kayhan Nilay , Akmese Pelin Pistav
Published: October 2018

This study aims to examine the compulsory courses related to the game and game teaching in special education teacher training undergraduate programme in terms of number, term, credit and content. The data in descriptive study have been determined using document analysis technique. It has been stated that pre-service teachers in most of the EU countries such as Belgium, Finland, Hungary, Luxemburg, Malta, Portugal, etc. take the courses related to game teaching in the first, second and third years of their education, and the courses with the lowest credit are included in Greeceâ€™s and Hollandâ€™s special education teacher training programmes with four ECTS and the highest credits are included in Maltaâ€™s special education teacher training programme with 20 ECTS. In Turkey, special education teacher training programme which is updated in 2018 includes two ECTS of â€˜Game and Music in Special Educationâ€™ course in the sixth term. Keywords: Special education, teacher training programme, game, game teaching.
Psychometric Properties of the Brief Symptom Inventory Hostility Subscale in Patients With Heart Failure
Authors: Roser Lynn P. , Hall Lynne A. , Moser Debra A.
Published: October 2018

Background and Purpose: Patients with heart failure (HF) often have increased hostility. The Brief Symptom Inventory (BSI) Hostility subscale has not been evaluated in this population. The purpose of this study was to explore dimensionality, internal consistency, and construct validity of BSI Hostility subscale in HF. Method: Measures examined were BSI Hostility, Depression, and Anxiety subscales; Patient Health Questionnaire-9 (PHQ-9); and Multidimensional Scale of Perceived Social Support (MSPSS). Cronbach's alpha, exploratory factor analysis, and correlational analysis were used. Results: Cronbach's alpha for the BSI Hostility subscale was .77. Hostility was positively associated with the PHQ-9, BSI Depression, and Anxiety subscales and negatively related to the MSPSS. Discussion: The BSI Hostility subscale provides a reliable and valid measure of hostility in patients with HF.
A vivência do acompanhamento pré-natal segundo mulheres assistidas na rede pública de saúde
Authors: Silva Ana Caroline Dias da , Pegoraro Renata Fabiana
Published: October 2018

Esta pesquisa objetivou identificar a vivência de familiares em relação a comunicação, tomada de decisão e manejo da entrada de crianças e adolescentes para visitar os pacientes internados em UTI adulto. A abordagem deste estudo foi qualitativa. Foram realizadas entrevistas com 10 familiares de pacientes que estiveram internados em UTI. Os dados foram analisados de acordo com a análise de conteúdo de Bardin (2009), emergindo quatro categorias: Comunicação; Tomada de decisão sobre a visita; Manejo, e Repercussões da visita. A comunicação dos participantes com os menores foi aberta. A tomada de decisão dependeu da inter-relação entre o desejo de visitar, o estado do paciente, o imaginário da visita e o posicionamento da equipe. Em relação ao manejo, todos destacaram a importância da preparação pré-visita. O estabelecimento de diretrizes claras nas instituições, assim como a capacitação dos profissionais acerca da visita de crianças, poderia contribuir para a prática em saúde.
La psicología clínica ante el sujeto de la contemporaneidad
Authors: Jaramillo Juan , Sandoval Carlos
Published: October 2018

Se presentan algunas tensiones y retos para la psicología clínica derivados de las características y necesidades de los sujetos de la contemporaneidad. Para ello se discute el tipo de sujeto en el que tradicionalmente se ha basado, las diferencias con el sujeto contemporáneo y las consecuencias de dichas diferencias para ella, encontrando cuatro tensiones primordiales: la relativización del telos progreso, el cuestionamiento a la adaptación y a la responsabilidad como premisas normalizadoras, y la emergencia del deseo como criterio ético fundamental. Ellas implican nuevas problemáticas y exigencias para la psicología clínica que la confrontan en sus fundamentos ontológicos, epistemológicos y metodológicos, obligándola a revisar sus supuestos formativos, conceptuales y de intervención. Se concluye la necesidad de una profunda revisión de la psicología clínica que le permita adecuarse en sus procesos formativos, conceptuales y aplicados, con el fin de hacerla pertinente a las características y necesidades de los sujetos en la contemporaneidad.
Diagnostic Performance of Initial Serum Albumin Level for Predicting in-Hospital Mortality Among Necrotizing Fasciitis Patients
Authors: Chang Chia-Peng , Fann Wen-Chih , Wu Shu-Ruei , Lin Chun-Nan , Chen I-Chuan , Hsiao Cheng-Ting
Published: October 2018

Background: Hypoalbuminemia is known to be associated with adverse outcome in critical illness. In this study, we attempted to identify if hypoalbuminemia on emergency department (ED) arrival a reliable predictor for in-hospital mortality in necrotizing fasciitis (NF). patients. Method: A retrospective cohort study of hospitalized patients with NF was conducted in a tertiary teaching hospital in Taiwan between March 2010 and March 2018. Blood samples were collected in the ED upon arrival, and serum albumin levels were determined. we evaluated the predictive value of serum albumin level at ED presentation for in-hospital mortality. All collected data were statistically analyzed. Result: Of the 707 NF patients, 40 (5.66%) died in the hospital. The mean serum albumin level was 3.1 ± 0.9 g/dL and serum albumin levels were significantly lower in the non-survivor group than in the survivor group (2.8± 0.7 g/dL vs. 3.5 ± 0.8 g/dL). In the multivariable logistic regression model, albumin was associated with in-hospital mortality significantly (odds ratio[OR] 0.92, 95% confidential interval (CI) 0.88–0.96, P <0.001). The area under-the-receiver-operating-characteristic curve (AUC) for in-hospital survival was 0.77 (95% CI 0.72–0.82) and corresponding sensitivity, specificity, positive predictive value, negative predictive value, positive and negative likelihood ratio were 66%, 74%, 33%, 88%, 2.25 and 0.48, respectively. High sensitivity (96%) was shown at albumin level of 4.0 g/dL and high specificity (91%) was shown at level of 2.5 g/dL. Conclusion: Initial serum albumin levels were independently associated with in-hospital mortality among adult patients with necrotizing fasciitis and demonstrated fair discriminative performance in the prediction of in-hospital mortality. NF patients with hypoalbuminemia on ED arrival should be closely monitored for signs of deterioration and consider early and aggressive intervention to prevent mortality.
The Impact of Pt Concentration on Crystal Growth Mechanism in Pt-Pd Binary Alloy System in the Context of Molecular Dynamics
Authors: Kizilagac Servet , Celik Fatih Ahmet , Koksal Koray
Published: October 2018

This work aims to investigate the effect of Pt concentration on crystal growth mechanism of Platinum-Palladium (Pt-Pd) binary alloy system during the annealing process starting from amorphous phase until some definite temperatures. The calculations have been performed by using molecular dynamic (MD) simulations. Interatomic interactions are described by on Sutton-Chen type Embedded Atom Potential Energy function. In order to understand the main structural properties at the stable and unstable phases, changes in RDF curves versus time have been analysed for different annealing temperatures. Crystalline type bonded pairs have been determined using MD calculations which is required for the computation of Avrami coefficients and for understanding crystal growth mechanism. The results demonstrate that the increase in concentration of Pt during annealing leads to migration of atoms in the crystal lattice points, elimination of dislocations and formation of perfect crystal structure.
Improving Distribution Process Using Lean Manufacturing and Simulation: A Case of Mexican Seafood Packer Company
Authors: Aguilar-Duque Julián I. , Hernandez-Arellano Juan L. , Balderrama-Armendariz Cesar Omar , Amaya-Parra Guillermo , Avelar Liliana
Published: October 2018

During the last decades, the production systems have developed different strategies to increase their competitiveness in the global market. In a manufacturing and services systems, Lean Manufacturing has been consolidated through the correct implementation of its tools. The present paper presents a case study developed in a Food Packer company where a Simulation Model was considered as an alternative to reduce the waste time generated by the poor distribution of operations and transportation areas for a product within the factory. As a matter of fact, the company has detected problems on the layout distribution that prevents to fulfill the market demand. In addition, the principal aim was to create a simulation model to test different hypothetical scenarios and alternative designs for the layout distribution without modifying its facilities. Moreover, the implemented methodology was based on classical models of simulation projects and a compendium of the manufacturing systems optimization by simulation process used during the last ten years. Also, a mathematic model supported by the Promodel ® simulation software was developed considering the company characteristics; along with the model development, it was possible to compare the production system performance from the percentage of used locations, the percentage of resources utilization, the number of finished products, and the level of Work in Process (WIP). Finally, the verification and validation stages were performed before running the scenarios in the real production area. The results generated by the implementation of the project represent an increase of 68% in the production capacity and a reduction of 5% in the WIP. In addition, both outcomes are associated with the resources management, which were reassigned to other production areas.
Towards Biohydrogen Separation Using Poly(ionic liquid)/ionic Liquid Composite Membranes
Authors: Gouveia Andreia S.L. , Ventaja Lucas , Tome Liliana C. , Marrucho Isabel M.
Published: October 2018

Considering the high potential of hydrogen (H2) as a clean energy carrier, the implementation of high performance and cost-effective biohydrogen (bioH2) purification techniques is of vital importance, particularly in fuel cell applications. In this context, membrane technology is a potentially energy-saving solution to obtain high-quality biohydrogen. The most promising poly(ionic liquid) (PIL) - ionic liquid (IL) composite membranes previously studied by our group for CO2/N2 separation, containing pyrrolidinium-based PILs with fluorinated or cyano-functionalized anions, were chosen as starting point to explore the potential of PIL–IL membranes for CO2/H2 separation. The CO2 and H2 permeation properties at the typical conditions of biohydrogen production (T =308 K and 100 kPa of feed pressure) were measured and discussed. PIL–IL composites prepared with [C(CN)3]– anion showed higher CO2/H2 selectivities and H2 diffusivities compared to those containing [NTf2]– anion. All the membranes revealed CO2/H2 separation performances above the upper bound for this specific separation, highlighting the composite incorporating 60 wt% of [C2mim][C(CN)3] IL.
Multi-port Current Source Inverter for Smart Microgrid Applications: A Cyber Physical Paradigm
Authors: Senthilnathan Karthikrajan , Annapoorani K Iyswarya
Published: October 2018

This paper presents a configuration of dual output single phase current source inverter with 6 switches for microgrid applications. The inverter is capable of delivering power to two independent set of loads of equal voltages or different voltages at the load end. The control strategy is based on Integral Sliding Mode Control (ISMC). The remote monitoring of the inverter is performed with cyber infrastructure. The cyber physical test bench is developed based on Reconfigurable I/O processor (NI MyRIO-1900) for control and monitoring of the inverter. The inverter prototype is tested in cyber physical test bench in laboratory conditions. The performance of the inverter is analyzed and monitored through the remote system. Also, the inverter is analyzed with different voltage conditions.
Process modeling for historical buildings restoration: an innovation in the management of cultural heritage
Authors: Malagnino Ada , Mangialardi Giovanna , Zavarise Giorgio , Corallo Angelo
Published: October 2018

Cultural heritage is a complex ecosystem requiring innovative methods and techniques to facilitate its restoration, management and valorization. In detail, restoration processes have to preserve the original characteristics of historical buildings or sites, by involving different professional figures, each one with different roles, responsibilities and skills. In this light, a system that facilitates the information management, supported by new technologies, could allow more precise, efficient and traceable information exchange and could optimize the construction and management operative phase. Starting from these assumptions, the research proposes the application of a new integrated approach to a  restoration process of a historical building. It consists of applying Business Process Management (BPM) approach and Building Information Modeling (BIM) methodology to provide valuable insights to optimize the data flow, to gather information and to share knowledge during the restoration process, by  optimizing the whole lifecycle management process, by facilitating the ordinary and extraordinary maintenance. All these aspects are essential and strategic for the Italian cultural heritage.
Nuevos avances en el conocimiento sobre el urbanismo de Colonia Patricia Cordvba en el sector ocupado por el templo romano
Authors: JIMÉNEZ SALVADOR José Luis , RUIZ LARA Dolores , MORENO ALMENARA Maudilio
Published: October 2018

Presentamos los resultados de la excavación arqueológica realizada en 1995 en el solar de la calle María Cristina, situado a espaldas del templo romano de la calle Claudio Marcelo. Esta intervención ha confirmado la existencia de un kardo de la ciudad romana coincidente con la actual calle María Cristina y ha propiciado el descubrimiento de una cloaca de similares características a la recientemente identificada con el kardo maximus.
Magia en la Córdoba romana
Authors: VENTURA VILLANUEVA Ángel
Published: October 2018

Damos a conocer dos tabellae defixionum aparecidas en la necrópolis oriental de Corduba y una «figurilla de voodoo» plúmbea procedente del cerro de Masatrigo (antigua Mellaria). A partir de su estudio nos aproximamos al conocimiento de las prácticas mágicas en la vida cotidiana de la sociedad hispanorromana.
Consideraciones en torno a los recipientes ibéricos con soportes de «manos»: el hallazgo de Hinojosa del Duque (Córdoba)
Authors: VERA RODRÍGUEZ Juan Carlos
Published: October 2018

Por contra al punto de vista de la historiografía tradicional, el análisis de un recipiente metálico con «asas de manos» de época Ibérica y el estudio de otros hallazgos similares con variados contextos arqueológicos, nos permite llegar a la conclusión de que no existen evidencias seguras para considerar como eminentemente rituales a este tipo concreto de piezas.
Cerámicas africanas de Córdoba
Authors: ALONSO de la SIERRA FERNÁNDEZ Juan
Published: October 2018

Con el análisis de un conjunto de cerámicas africanas procedentes de varias ex-cavaciones arqueológicas reflexionamos sobre algunos aspectos de su comercializa¬ción en la ciudad. En los primeros tiempos las cerámicas de cocina tuvieron mayor difusión y las de mesa compitieron sucesivamente con sigillatas hispánicas y otras producciones locales tardías. Hacia mediados del s. V se produce una recesión irre¬versible en las importaciones.
La estela de la Ribera Alta (Córdoba): consideraciones en torno a las estelas decoradas con escudo, espada y lanza
Authors: MURILLO REDONDO Juan F.
Published: October 2018

En este trabajo partimos de una somera revisión de los principales paradigmas (interpretativos, tipológicos y cronológicos) asumidos por los investigadores que se han ocupado de las estelas decoradas del Suroeste de la Península Ibérica para reinterpretar de un modo crítico, a partir de una nueva estela hallada junto al Guadalquivir, uno de ellos: la prioridad cronológica de las estelas en las que se representa el escudo flanqueado por la espada y por la lanza y, consecuentemente, el origne en el Norte de Extremadura de esta importante manifestación del Bronce Final peninsular.
Nueva aportación al conocimiento de los pavimentos musivos en la villa romana de El Ruedo (Almedinilla, Córdoba)
Authors: MORENO GONZÁLEZ Manuel Fdo.
Published: October 2018

Pretendemos en el presente artículo dar a conocer los esquemas ideales, obtenidos mediante tratamiento informático, de cinco de los mosaicos romanos de la villa de El Ruedo (Almedinilla, Córdoba), contribuyendo así a completar el estudio monográfico que hace ya algunos años fue publicado en esta misma revista (HIDALGO, 1991), e incorporando las numerosas novedades que se vienen produciendo en la investigación sobre el yacimiento (VAQUERIZO, 1990; VAQUERIZO et alii, 1994; VAQUERIZO, CARRILLO, 1994, e.p.; CARRILLO, 1990 y 1992)
Una lucerna romana de bronce, con decoración zoomorfa, procedente de Fuenlabrada de los Montes (Badajoz)
Authors: VAQUERIZO GIL Desiderio , AMARE TAFALLA Mª. Teresa
Published: October 2018

Damos a conocer en esta breve nota una lucerna romana de bronce, con decoración zoomorfa, recuperada de forma casual -mediante detector de metales- en una posible villa o establecimiento similar ubicado en las proximidades de la actual Fuenlabrada de los Montes (Badajoz). Es una zona donde, por el momento, la información arqueológica de que disponemos nos habla de un poblamiento más bien disperso -no existen ciudades conocidas en bastantes kilómetros a la redonda-, muy probablemente en relación con la cabaña ganadera, el control de rutas de comunicación -la más importante, el Guadiana-, y, sin lugar a dudas, la riqueza ginecética, de la que sería buena prueba el motivo que adorna la pieza.
Susum ad montes S(ocietatis) S(iasponensis): nueva inscripción tardorrepublicana de Corduba
Authors: VENTURA VILLANUEVA Ángel
Published: October 2018

Damos a conocer una nueva inscripción cordobesa fechable a mediados del s. I a.C. que documenta la existencia de una servitus viae, con un ancho de 14 pies, impuesta por la Societas Sisaponensis. Analizamos la evidencia histórica y arqueológica para tratar de identificar la traza y significado económico de este camino minero. El texto, hoy por hoy, constituye un unicum de la epigrafía latina, que aporta nuevos datos para la historia del Derecho Romano en aspectos referentes a las servidumbres del paso.
The use of antibiotics in newborns: effects on gastrointestinal microbiome and long-term results
Authors: Vandenplas Yvan
Published: October 2018

A balanced gastrointestinal microbiome is crucial for the development of the immune system. The use of antibiotic therapy in infants often leads to intestinal dysbiosis. This article presents a convincing argument that the use of antibiotics in infants and young children affects their health in the future. The purpose of antibiotic therapy in childhood should be well thought out, because its negative effect on the gastrointestinal tract the ability to cause diarrhoea, has been proven, and, in addition, antibiotics have long-term effects: overweight, irritable bowel syndrome (IBS), allergic diseases. Conclusion: clinicians should weigh the need and consequences of using antibiotics in infancy and early childhood.
New possibilities for asthma therapy in children
Authors: Surovenko T. N. , Glushkova Е. F.
Published: October 2018

This article discusses issues of clinical diagnosis and course of bronchial asthma in children. We discuss assessment of asthma severity and, accordingly, the extent of the step-by-step therapy according to updated recommendations (GINA 2018). Particular attention is paid to the possibility of improving the control of asthma with the help of the M-cholinolytic drug of long-acting tiotropium bromide, presented as a special inhalation form of tiotropium Respimat and registered in the Russian Federation for treatment of asthma in children of moderate and severe course from 6 years of age. Application tiotropium Respimat in children with insufficient control of asthma allows to improve lung function and asthma control.
Healthy intestinal colonization in children: strong immunity
Authors: Pakhomovskaya N. L. , Venediktova М. M.
Published: October 2018

The article presents actual data on the composition and functions of the intestinal microbiota, and examines the mechanisms of the microbiota effect on the macroorganism’s health state. The necessity and possibility of correction of microbiota are shown by the analysis of the composition and evaluation of the functions of the intestinal microbiota, and the mechanisms of the symbiotic relationship «microflora macroorganism» and the causes leading to the development of intestinal dysbiosis. The main groups of preparations (probiotics, prebiotics, synbiotics) used for correction of intestinal microbiocenosis are presented by taking into account the modern guidelines.
Laparoscopic interventions in children with complicated appendicitis
Authors: Korovin S. A. , Dzyadchik A. V. , Dvorovenko E. V. , Sokolov Yu. Yu.
Published: October 2018

The article presents an overview of laparoscopic appendectomy experience in 3,766 children with complicated appendicitis in the clinic of the Department of Paediatric Surgery of the Russian State Medical Academy of Continuous Vocational Education (Moscow). The authors showed the high efficiency of laparoscopic techniques in the operative treatment. The features of tactics in destructive appendicitis and peritonitis are highlighted.
The effect of additional nutritional support as part of the rehabilitation program on the quality of life and morbidity in children with recurrent respiratory pathology
Authors: Akhmetshin R. Z. , Druzhinina N. A. , Nasibullina L. M. , Shiryaeva G. P. , Bakieva Ch. R. , Semavina L. Yu.
Published: October 2018

Objective of the study: Assess the health and quality of life in children with recurrent respiratory pathology and justify the effectiveness of comprehensive rehabilitation program to improve health involving additional nutritional support.

Materials and methods: 101 children aged 5–9 years with recurrent respiratory pathology received a non-comparative clinical examination and rehabilitation. The first group included 75 children with disorders of nutritional status that were identified upon results of physical examination, anthropometric measurements, including body composition analysis (bioimpedance measurement), biochemical parameters and actual nutrition evaluation. The observed children of the main group received «PediaSure with fiber» functional product as part of the complex rehabilitation therapy to replenish the diet with the basic nutrients, vitamins and trace elements. The second group of 26 children comparable in age and gender, but not having disorders of nutritional status was allocated in order to assess the impact of the nutritional deficiency on the severity of recurrent respiratory disease. Those children received only general health therapy and usual sanatorium traditional food. The effectiveness of the therapy was assessed on the basis of the positive dynamics of the nutritional status and the quality of life study using the questionnaire Pediatric Quality of Life Questionnaire (Generic Core Scales). The study was conducted in Duslyk children’s sanatorium in Ufa.

Results: The comprehensive health improvement program and additional nutritional support in children with recurrent respiratory pathology showed a significant improvement in anthropometric data, a 2.5-fold decrease in the average number (from 7.12 to 2.9, p <0.05), and 1.8 -fold decrease in the average duration (from 11.88 to 6.76 days, p <0.05) of episodes of recurrent respiratory infections, and also allowed to achieve significant improvement in all parameters of the children’s quality of life.

Conclusion: The comprehensive health improvement program and additional nutritional support in children with recurrent respiratory pathology contribute to improving the quality of life, increasing adaptive capacity, reducing the frequency and duration of acute respiratory infections.
Experience of early diagnosing of Bland-White-Garland syndrome in paediatric practice
Authors: Prostakova V. N. , Chernova N. D. , Perova S. V. , Zaitseva Е. N. , Anisimova S. I. , Mashigina A. Yu. , Meshcheryakova O. D. , Rakhaeva Yu. A. , Koryakina Е. V.
Published: October 2018

Myocardial infarction and acute coronary syndrome in children is referred to as a rare congenital anomaly up to the present date. However, despite the rarity of this syndrome, practicing pediatricians, cardiologists should be cautious about the disease in order to avoid the fatal consequences of untimely diagnosis. The article describes the main causes, pathogenesis, clinical picture, treatment tactics and disease prognosis – according to the literature of Russian and foreign authors, and presents a clinical discussion of the case of early detection of the Bland-White-Garland syndrome during the planned outpatient examination of the child.
Breast milk oligosaccharides: one more step on the path to making infant formulas more like a «gold standard» for infant feeding
Authors: Zakharova I. N. , Dmitrieva Yu. A. , Yagodkin M. V.
Published: October 2018

Breast milk is the «gold standard» for infant feeding. Its unique properties are due to the balanced macroand micro-nutrient composition and the presence of a whole range of functional components that have a multifaceted impact on the postnatal development of the baby’s organs and tissues. The carbohydrate fraction is currently of great interest to the researchers. Particular attention is paid to the human milk oligosaccharides (HMO), which are the third largest component in human milk after fat component and lactose in concentration. The main HMOs are fucosylated molecules – 2’-fucosyllactose (2’-FL) and 3’-fucosyllactose (3’-FL), lacto-N-fucopentaose (LNFP I, II, III), as well as some neutral and acidic oligosaccharides. The numerous laboratory and clinical studies showed that HMOs are the key nutrients that contribute to the formation of the intestinal microbiota of the infant, provide an anti-infectious and immunological effect, and participate in the postnatal formation of brain structures. If breastfeeding is not possible, the milk formula is likely to be the sole source of oligosaccharides for infants. The introduction of breast milk oligosaccharides into the baby food composition is an important stage in adaptation of such foods and making those more like the “gold standard” of feeding in composition.