bluuebunny/crossref_metadata_2025 huggingface dataset:
Жіноча сексуальна дисфункція — мультидисциплінарна проблема розладів репродуктивного здоров’я жінок фертильного віку. Огляд літератури
Authors: Крижановська О. І.
Published: December 2023

Розглянуто питання впливу жіночої сексуальної дисфункції на репродуктивне здоров’я жінок. Проаналізовано вплив коморбідної патології на особливості стероїдного гомеостазу жіночого організму. Даних щодо поширеності жіночої сексуальної дисфункції у літературі мало. За оцінками, поширеність сексуальної дисфункції у жінок становить 43—90%. Дослідженнями встановлено, що гормональний дисбаланс, спричинений ендокринопатіями, синдромом полікістозних яєчників, ожирінням, метаболічними розладами, цукровим діабетом і деякими методами гормональної контрацепції, також пов’язаний із сексуальною дисфункцією в жінок, зокрема показано роль автоімунних захворювань щитоподібної залози в маніфестації клінічних виявів жіночої сексуальної дисфункції у фертильних жінок. Із можливих тригерів зниження рівня андрогенів у жінок розглянуто гіпергомоцистеїнемію. Патогенетичним підґрунтям вважають активацію оксидантного стресу, ендотеліальної дисфункції, зниження біодоступності оксиду азоту. Відзначено негативний вплив зазначених процесів на фолікулярний ріст і формування прозапального внутрішньофолікулярного тла з формуванням ендометріозу яєчників та блокуванням ароматазного ферменту гранульозної тканини. Порушення умов для правильного росту фолікула призводить до порушення менструальної функції та безпліддя в жінок з ендометріозом та жіночою сексуальною дисфункцією. Психологічні наслідки ендометріозу та жіночої сексуальної дисфункції, такі як депресія, тривожність, безсилля, почуття провини, погіршення міжособистісних стосунків, призводять до збільшення кількості розлучень серед молодих пар. З огляду на особливості формування сексуальної дисфункції в жінок репродуктивного віку та її поліморбідне тло, алгоритми обстеження та лікування мають бути персоніфікованими, а для подолання проблеми слід залучати мультидисциплінарну команду лікарів.
La conquista saudita de Al Hasa
Authors: Rodriguez Flores Roberto Lautaro
Published: December 2023

En mayo de 1913, Abdulaziz bin Abdelrahmán al Saud, el emir de Riad y un vasallo nominal del Imperio otomano, atacó y desalojó a la guarnición otomana de Al Hasa. El episodio, que acabó con la presencia efectiva de la Sublime Puerta en el este de la península Arábiga, ha recibido escasa atención historiográfica y ha sido subordinado a un más general avance del Imperio británico en la región. Aquí proponemos un abordaje alternativo, que pone en el centro del problema y de su explicación a las características de la presencia de Estambul en estos remotos dominios, y a un elemento constitutivo de esta última: sus relaciones con sus vasallos nominales sauditas.
Reseña bibliográfica de: Mauro, D. (Coord.) (2021). Devociones marianas. Catolicismos locales y globales en Argentina, desde el siglo XIX a la actualidad. Rosario: Prohistoria, 300 pp.
Authors: Bruchmann Tanodi Agustina
Published: December 2023

Es la reseña de un libro reciente
Exploration of the Pharmacological Mechanism of Vitexicarpin against Triple-Negative Breast Cancer in Network Pharmacology
Authors: Wu Tianhui , Xiang Min , Li Yujiao , Gao Yahan , Teng Da , Sun Minxuan , Guo Weiqiang , Zhou Yuanshuai
Published: December 2023

Background: Vitexicarpin (VIT), an isoflavone derived from various medicinal herbs, has shown promising anti-tumor activities against multiple cancer cells. However, the understanding of the mechanisms and potential targets of VIT in treating triple-negative breast cancer (TNBC) remains limited. Methods: The potential VIT targets were searched for in the Super-PRED online database, while the TNBC targets were acquired in the DisGeNET database, and the Veeny database was used to identify the VIT and TNBC targets that overlapped. Then, GO and KEGG enrichment analyses were carried out in the DAVID database. The protein–protein interaction (PPI) network was constructed to acquire the hub targets in the STRING database, and the overall survival analysis of the hub targets was examined in the Kaplan–Meier plotter database. Afterward, molecular docking was performed to evaluate the binding capabilities between VIT and the hub targets. In order to measure the effect of VIT on proliferation, apoptosis, and cell cycle arrest in the TNBC cell lines—MDA-MB-231 and HCC-1937—the Cell Counting Kit-8 (CCK-8) assay and flow cytometry analysis were performed. The Western blot and pull-down assays were used to verify the molecular mechanisms by modulating the hub targets. Results: The network pharmacology results identified a total of 37 overlapping genes that were shared by VIT and TNBC. The results of the PPI network and molecular docking analyses showed that HSP90AA1, CREBBP, and HIF-1A were key targets of VIT against TNBC. However, the pull-down results suggested that VIT could directly bind to HSP90AA1 and HIF-1A, yet not to CREBBP. The results of the in vitro tests showed that VIT decreased proliferation and induced apoptosis in MDA-MB-231 and HCC-1937 cells, in a dose-dependent manner, while the cell cycle arrest occurred at the G2 phase. Mechanistically, the Western blot assay demonstrated that VIT decreased the expression of HSP90AA1, CREBBP, and HIF-1A. Conclusions: VIT inhibited growth and induced apoptosis of TNBC cells by modulating HIF-1A, HSP90AA1, and CREBBP expression. Our findings suggest that VIT is a potential drug for TNBC therapy.
im5C-DSCGA: A Proposed Hybrid Framework Based on Improved DenseNet and Attention Mechanisms for Identifying 5-methylcytosine Sites in Human RNA
Authors: Jia Jianhua , Qin Lulu , Lei Rufeng
Published: December 2023

Background: 5-methylcytosine (m5C) is a key post-transcriptional modification that plays a critical role in RNA metabolism. Owing to the large increase in identified m5C modification sites in organisms, their epigenetic roles are becoming increasingly unknown. Therefore, it is crucial to precisely identify m5C modification sites to gain more insight into cellular processes and other mechanisms related to biological functions. Although researchers have proposed some traditional computational methods and machine learning algorithms, some limitations still remain. In this study, we propose a more powerful and reliable deep-learning model, im5C-DSCGA, to identify novel RNA m5C modification sites in humans. Methods: Our proposed im5C-DSCGA model uses three feature encoding methods initially—one-hot, nucleotide chemical property (NCP), and nucleotide density (ND)—to extract the original features in RNA sequences and ensure splicing; next, the original features are fed into the improved densely connected convolutional network (DenseNet) and Convolutional Block Attention Module (CBAM) mechanisms to extract the advanced local features; then, the bidirectional gated recurrent unit (BGRU) method is used to capture the long-term dependencies from advanced local features and extract global features using Self-Attention; Finally, ensemble learning is used and full connectivity is used to classify and predict the m5C site. Results: Unsurprisingly, the deep-learning-based im5C-DSCGA model performed well in terms of sensitivity (Sn), specificity (SP), accuracy (Acc), Matthew’s correlation coefficient (MCC), and area under the curve (AUC), generating values of 81.0%, 90.8%, 85.9%, 72.1%, and 92.6%, respectively, in the independent test dataset following the use of three feature encoding methods. Conclusions: We critically evaluated the performance of im5C-DSCGA using five-fold cross-validation and independent testing and compared it to existing methods. The MCC metric reached 72.1% when using the independent test, which is 3.0% higher than the current state-of-the-art prediction method Deepm5C model. The results show that the im5C-DSCGA model achieves more accurate and stable performances and is an effective tool for predicting m5C modification sites. To the authors’ knowledge, this is the first time that the improved DenseNet, BGRU, CBAM Attention mechanism, and Self-Attention mechanism have been combined to predict novel m5C sites in human RNA.
Transcriptome and Pathway Analysis Reveals that Adipose-derived Stem Cells Target Inflammatory Factors and Delay the Progression of Diabetic Liver Disease
Authors: Hou Yanli , Gao Guoliang , Ding Wenyu , Wu Peishan , Liu Changqing , Lin Dong , Liu Deshan , Wang Xiaolei
Published: December 2023

Background: Diabetic liver disease is one of the main complications that leads to the aggravation of diabetes, but it has not received sufficient attention. This study aimed to provide a better understanding of the altered molecular networks in in diabetic rats with liver damage after stem cell therapy. To a certain extent, our research would be instructive, since almost no studies of this kind have been performed on patients with diabetic liver disease after stem cell therapy. Methods: Streptozotocin-induced diabetic rats were treated with adipose-derived stem cells. RNA-Seq analysis was performed on the liver tissues of these animals, and key pathway factors were further identified and validated. Results: RNA-Seq analysis revealed numerous affected signaling pathways and functional categories. The results showed that the network of dual specificity phosphatase 1 (DUSP1), an oxidative stress-related gene, was prominently activated in the liver after stem cell therapy, and the enrichment of genes associated with liver damage, steatosis and fibrosis was also detected. The extracellular regulated protein kinase (ERK)/signal transducer and activator of transcription 3 (STAT3) signaling pathway may be involved in this process by regulating the nucleotide-binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome. Conclusions: These data provide novel insights into liver biology, suggest common alterations in the molecular networks during diabetic liver damage, and show the advantages of stem cell therapy, indicating its further application potential for early treatment of diabetic liver damage and delaying the progression of liver fibrosis in the later stage.
Canthaxanthin Attenuates the Vascular Aging or Endothelial Cell Senescence by Inhibiting Inflammation and Oxidative Stress in Mice
Authors: Wang Zhefeng , Li Lilin , Liao Souqi , Huang Ren , Jiang Yibo , Fei Jia , Cai Lijun , Zhang Keda
Published: December 2023

Background: Vascular endothelial dysfunction is an early phenotype of aging-related vascular dysfunction. Delaying vascular aging and preventing cardiovascular disease are major public health problems that urgently need to be solved. Scientists have studied various drugs to prevent the occurrence and progress of cardiovascular disease, but progress has been slow. Here, the antisenescence and anti-endothelial damage of canthaxanthin (CX, which is an active molecule from food) has been studied. Methods: This study was performed by adding CX to a model of cell senescence and oxidative damage induced by hydrogen peroxide. Cellular senescence markers (e.g., p16, p21, and p53) and oxidative damage markers (e.g., reactive oxygen species, nitric oxide, malondialdehyde, superoxide dismutase) were evaluated by the enzyme-linked immunosorbent assay, laser scanning confocal microscopy, and Western blotting. Results: We found that CX downregulated the expression level of senescence-associated molecules, and significantly reduced the oxidative damage of vascular endothelial cells. These observations showed that CX effectively alleviated the senescence of vascular endothelial cells. Furthermore, CX treatment reduced the expression levels of interleukin-6 (IL-6), tumor necrosis factor alpha, and IL-1β. Finally, in vivo, CX significantly alleviated vascular senescence. Conclusions: The current study shows that CX has potential application value for treating vascular aging or endothelial cell senescence.
Preparación policial para responder al delito informático en Ecuador.
Authors: Tamayo Benavides Santiago Marcelo
Published: December 2023

El presente estudio pretende describir y explorar la preparación del personal policial ecuatoriano para responder al delito informático, para lo cual se aplicó una encuesta cuyos datos se utilizaron para analizar la frecuencia de participación en capacitaciones enfocadas a delitos informáticos; su nivel de confianza individual y organizacional para responder a este tipo de delito; y, la percepción sobre cómo mejorar su respuesta ante estos hechos. Se realizó una revisión de las investigaciones existentes sobre la complejidad de las investigaciones de delitos informáticos y la preparación policial para responder a los incidentes informáticos. Entre las conclusiones del estudio se sugiere que los policías ecuatorianos pueden beneficiarse de una mayor capacitación en habilidades básicas relacionadas con el delito informático.
Gestión Logística y Adquisición de Bienes y Servicios en una Escuela de Postgrado
Authors: Ramal Álvarez Eduardo Antonio , Vigil Dávalos Milagros Josefina , Quispe Catti Otilia Carmen
Published: December 2023

El presente artículo tuvo como objetivo establecer la correlación entre la gestión logística y la adquisición de bienes y servicios en una escuela de postgrado. Se realizó una investigación correlacional y no experimental, para la cual se aplicó la técnica de la encuesta. Se evidenció que las dimensiones estrategias y políticas de compras, atención de requerimientos y el cumplimiento de objetivos y metas, registran una asociación significativa y positiva con la gestión logística.  Por lo que se concluye entonces que sí existe una correlación significativa y positiva entre la gestión logística y la adquisición de bienes y servicios en la Escuela de Postgrado.
Relación entre la gestión pública y el desarrollo sostenible, revisión literaria
Authors: Horna Torres Eleuterio , Peralta Tapia Manuela Esperanza , Horna Torres Enrique , Heredia Llatas Flor Delicia
Published: December 2023

La relación entre gestión pública y desarrollo sostenible ha sido estudiada a fondo mediante una revisión literaria global. Este análisis exploratorio examinó 50 artículos de revistas profesionales entre 2019 y 2021, seleccionados por criterios estrictos en temas de participación ciudadana y gestión pública. Los resultados revelaron cómo la gestión pública se vincula con los objetivos de desarrollo sostenible a través de fases clave como la prospectiva, estrategia e institucionalización, junto con el seguimiento. Se concluyó que centrarse en la gestión pública y su integración con el desarrollo sostenible es crucial para el funcionamiento efectivo de las instituciones gubernamentales, con énfasis en la planificación, control y ejecución adecuados, así como el mantenimiento sostenible de servicios públicos y una administración eficiente de recursos económicos.
Вплив способів основного обробітку ґрунту на урожайність гібридів кукурудзи в умовах Лівобережного Лісостепу
Authors: Гангур В. В. , Маренич М. М. , Єремко Л. С. , Шостя А. М. , Пузир Д. О. , Кирлиця А. О.
Published: December 2023

Кукурудза (Zea mays L.) завдяки важливим господарсько-цінним властивостям має різнобічне використання, зокрема як продовольча і зернофуражна, так і технічна культура (сировина для виробництва біоетанолу та біогазу). Дослідження, які проведено на дослідному полі Полтавської ДСГДС імені М. І. Вавилова впродовж 2022–2023 рр., свідчать, що у ранньостиглого гібрида Квітневий 187 МВ найнижча передзбиральна вологість зерна була за умови проведення поверхневого обробітку ґрунту на глибину 8–10 см (16,8 %). За умови вирощування гібрида на фоні плоскорізного обробітку та оранки на глибину 25–27 см вологість зерна зросла, відповідно на 0,4 і 1,7 % (абсолютних). Зерно середньораннього гібрида Оржиця 237 МВ краще віддавало вологу на фоні оранки на глибину 25–27 см, а на варіантах безполицевого обробітку ґрунту спостерігали збільшення її вмісту на 0,8–1,2 % (абсолютних). Таку ж тенденцію виявлено і в середньостиглого гібрида Бистриця 400 МВ. За результатами досліджень виявлено, що ранньостиглий гібрид Квітневий 187 МВ та середньоранній Оржиця 237 МВ формували найвищу і практично однакову урожайність (відповідно 7,59 і 7,45 т/га) у разі проведення оранки та плоскорізного обробітку на глибину 25–27 см. Істотне зниження урожайності цих гібридів кукурудзи спостерігали за умови поверхневого обробітку на 8–10 см. Різниця в урожайності порівняно з кращими варіантами обробітку ґрунту становила, відповідно 0,26–0,40 і 0,21–0,23 т/га. Середньостиглий гібрид Бистриця 400 МВ максимальну урожайність (7,91 т/га) формував за умови проведення полицевого обробітку на глибину 25–27 см. У разі заміни оранки на розпушування ґрунту знаряддями плоскорізного типу на аналогічну глибину або проведення поверхневого обробітку на глибину 8–10 см відзначено істотне зниження урожайності зерна, відповідно на 0,64 і 0,95 т/га або 8,1 і 12,0 %.
Стан компонентів сполучної тканини у коней за ожиріння
Authors: Боровков С. Б. , Тимошенко О.П. , Боровкова В. М.
Published: December 2023

У цій статті представлено результати вивчення впливу ожиріння на стан компонентів сполучної тканини у коней. Дослідження проведено на 20 конях обох статей, розділених на контрольну (здорові коні n=10) та експериментальну групу (коні з ожирінням n=10). Метою дослідження було визначити вплив ожиріння на структурні та біохімічні характеристики компонентів сполучної тканини в коней у нормі та оцінити їх діагностичні критерії при ожирінні. У дослідженні для визначення концентрації глікозаміногліканів (ГАГ) та їх фракцій, а також хондроітинсульфатів (ХСТ) у сироватці крові використовувалися біохімічні методи аналізу. Отримані результати проаналізували і визначили статистичну значущість отриманих величин, в таблицях зазначали такі показники: Медіана, квартилі Q1 та Q3, достовірну різницю між групами встановлювали на основі розрахунку критерія Mann-Whitney (p≤0,05), кореляційні зв’язки визначали з використанням методу Пірсона. Відповідно, в роботі висвітлено результати дослідження стану компонентів сполучної тканини у коней з ожирінням, де особливу увагу приділено аналізу глікозаміногліканів та хондроітинсульфатів у сироватці крові. Розуміння змін цих компонентів у сироватці крові має важливе значення для розробки персоналізованих стратегій лікування та управління здоров’ям коней з ожирінням, сприяючи тим самим збереженню оптимальної функціональності та міцності їх опорно-рухового апарату. Виявлено суттєві достовірні зміни концентрації хондроітинсульфатів, глікопротеїнів та їх фракцій у здорових коней та коней із ожирінням. Це вказує на потенційні проблеми з міцністю та еластичністю сполучної тканини кісток та суглобів, а саме опорно-рухового апарату у коней при ожирінні. Висновки дослідження свідчать про те, що ожиріння відзначається негативним впливом на стан компонентів сполучної тканини у коней. Це може призвести до зниження рухливості та працездатності тварин, а також підвищити загальний ризик травм.
The iterative development and refinement of health psychology theories through formal, dynamical systems modelling: A scoping review and initial expert-derived ‘best practice’ recommendations
Authors: Perski Olga , Copeland Amber , Allen Jim , Pavel Misha , Rivera Daniel E. , Hekler Eric B. , Hankonen Nelli , Chevance Guillaume
Published: December 2023

This scoping review aimed to synthesise the methodological steps taken by researchers in the development of formal, dynamical systems models of health psychology theories pertaining to health behaviours unfolding at the within-person level. We searched Ovid MEDLINE, PsycINFO, the ACM Digital Library and IEEE in July 2023. We included studies of any design providing that they reported on the development, refinement and/or testing of a formal, dynamical systems model, with no restrictions on population or setting. A narrative synthesis with frequency analyses was conducted, which informed the development of an initial set of ‘best practice’ recommendations. A total of 17 modelling projects reported across 29 studies were included. We found that current health psychology modelling efforts have largely been concentrated to a small number of interdisciplinary teams in the United States (79.3%). The models aimed to better understand dynamic processes (69.0%) or inform the development of adaptive interventions (31.0%). Models typically aimed to formalise the Social Cognitive Theory (31.0%) or the Self-Regulation Theory (17.2%) and varied in complexity (range: 3-30 model variables and free parameters). Only 3.4% of studies reported involving stakeholders in the modelling process and 10.3% drew on Open Science practices. Formal, dynamical systems modelling is poised to help health psychologists develop and refine theories, ultimately enabling the development of more potent interventions.
Resume 7 PO_Team Dynamics
Authors: Azizah Irma Nur
Published: December 2023

Tim adalah kelompok dari dua atau lebih orang yang berinteraksi dan mempengaruhi satu sama lain, saling bertanggung jawab untuk mencapai tujuan bersama, dan menganggap diri mereka sebagai entitas sosial dalam sebuah organisasi. Kelompok adalah dua orang atau lebih yang memiliki hubungan pemersatu
TEORI STRUKTURAL DALAM ANALISIS BIROKRASI PEMERINTAHAN
Authors: Latif Nur Aulia Arianto
Published: December 2023

Artikel ini membahas peran teori struktural dalam analisis birokrasi pemerintahan. Teori struktural merupakan kerangka kerja penting yang memungkinkan pemahaman mendalam tentang bagaimana struktur organisasi pemerintah memengaruhi tindakan dan keputusan di dalamnya. Penelitian ini mengeksplorasi bagaimana elemen-elemen struktural, seperti hierarki, spesialisasi, dan pembagian tugas, membentuk dinamika kekuasaan dan interaksi di dalam birokrasi pemerintahan. Metode penelitian yang digunakan dalam artikel ini dengan kualitatif kemudian mengumpulan data dengan cara studi kepustakaan. Melalui analisis teori struktural, artikel ini berupaya untuk memberikan wawasan yang lebih dalam tentang bagaimana birokrasi pemerintahan beroperasi dan bagaimana pengambilan keputusan dibentuk oleh faktor-faktor struktural. Dengan pemahaman ini, kita dapat mengembangkan rekomendasi kebijakan yang lebih baik untuk meningkatkan kinerja birokrasi pemerintahan, mendorong inovasi, dan memenuhi tuntutan masyarakat dalam era yang terus berubah. Artikel ini mendorong pembaca untuk menjelajahi dan mengaplikasikan teori struktural dalam konteks analisis birokrasi pemerintahan dengan tujuan memperbaiki tata kelola publik secara keseluruhan.
Consciousness and Chance: The Impact of Human Interaction on Mobile Game Randomness
Authors: Borges Flores Ana , Rapazote-Flores Paulo
Published: December 2023

The research aims to examine the statistical distribution of matrices generated in experimental sessions compared to control sessions.In recent studies, the phenomenon of mind-matter interaction has garnered considerable attention due to its significant findings. Our investigation seeks to determine whether a participant engaged in a mobile game can influence the 'behavior' of two distinct random number generators (RNGs). To establish a baseline, we employ a control scenario where the game operates on the same device unbeknownst to the player, thereby replicating the original conditions minus the player's psychological engagement. We correlate the participant's psychological metrics with the RNG outcomes, defined as physical variables, into structured matrices. By conducting a statistical analysis of both experimental and control matrices, we aim to discern any disparities that might shed light on potential interactive effects between the subject's mental state and the RNG behavior
Conflict Manajemen
Authors: Anggita Nadia
Published: December 2023

Konflik adalah proses di mana satu pihak merasakan bahwa kepentingannya sedang ditentang atau dipengaruhi secara negatif oleh pihak lain.
AI Revolution: Reshaping Global Value Chains for the Future
Authors: Yu Chen
Published: December 2023

The article "AI Revolution: Reshaping Global Value Chains for the Future" explores the transformative impact of artificial intelligence (AI) on global value chains (GVCs). It provides an in-depth analysis of the current landscape of traditional GVCs, the role of AI in reshaping value chains, implications and challenges arising from AI adoption, and future outlook and predictions. The article emphasizes the importance of adaptability, innovation, and responsible AI adoption in navigating the evolving landscape of AI-driven value chains.
Naturalizing Relevance Realization: Why agency and cognition are fundamentally not computational
Authors: Jaeger Johannes , Riedl Anna , Djedovic Alex , Vervaeke John , Walsh Denis
Published: December 2023

The way organismic agents come to know the world, and the way algorithms solve problems, are fundamentally different. The most sensible course of action for an organism does not simply follow from logical rules of inference. Before it can even use such rules, the organism must tackle the problem of relevance. It must turn ill-defined problems into well-defined ones, turn semantics into syntax. This ability to realize relevance is present in all organisms, from bacteria to humans. It lies at the root of organismic agency, cognition, and consciousness, arising from the particular autopoietic, anticipatory, and adaptive organization of living beings. In this paper, we show that the process of relevance realization is beyond formalization. It cannot be captured completely by algorithmic approaches. This implies that organismic agency (and hence cognition as well as consciousness) are at heart not computational in nature. Instead, we show how the process of relevance is realized by an adaptive and emergent triadic dialectic (a trialectic), which manifests as a metabolic and ecological-evolutionary co-constructive dynamic. This results in a meliorative process that enables an agent to continuously keep a grip on its arena, its reality. To be alive means to make sense of one's world. This kind of embodied ecological rationality is a fundamental aspect of life, and a key characteristic that sets it apart from non-living matter.
A moderated mediation model linking entrepreneurial leadership to green innovation: An upper echelons theory perspective
Authors: Abdul Qadeer , Adnan
Published: December 2023

Despite the dominant discourses on the important role of entrepreneurial leadership in firms' development, related theoretical and empirical studies are still lacking in the environmental management area. Adopting upper echelons theory, this study develops a moderated mediation model that examines how entrepreneurial leadership affects the adoption of green innovation (GI) through organizational learning culture and how environmental dynamism moderates the mediating effect. This theoretical model is tested using a sample of 248 Chinese firms. Findings support the positive impact of entrepreneurial leadership on GI and the mediating role of organizational learning culture. The moderated mediation path analysis shows that environmental dynamism moderates the indirect effect of entrepreneurial leadership on GI via organizational learning culture. Overall, this study adds to entrepreneurship and environmental management scholarship by providing novel insights into the key role of entrepreneurial leadership in embracing GI.
Management Control Syst: Performance Measurement
Authors: Rizdkia Mutiara
Published: December 2023

Catatan terkait dengan subjek Sistem Pengendalian Manajemen (Management Control System) mengenai Performance Measurement
Reframing the Indian Middle Class as a Labour Aristocracy
Authors: Sharma Aryaman
Published: December 2023

Taking from, and critiquing, both the scholarship on the Indian middle class as well as the scholarship on the ‘labour aristocracy’, this paper argues for the reformulation of the Indian “middle class” as a labour aristocracy or worker elite. We define the distinctive characteristics that set the Indian worker elite apart from the broader working class and highlight, through the case studies of international migration, patterns in urban living spaces and domestic service employment, the stark differences between the worker elite and the poor working masses in India, and the exploitative relationship that exists between the two. The analysis points to the semi-periphery being the locus of the largest inequalities in the capitalist world-system today, wherein the bourgeoisie and the worker elite both gain tremendously from the exploitation inherent to capitalism. Resultingly, the task at hand in India and the semi-periphery broadly remains to organize the poor, marginalised working masses.
Out of the Mind Journey into the Extended Mind Dimension
Authors: Sakib S M Nazmuz
Published: December 2023

In the ever-evolving landscape of psychology, the exploration of advanced theories is akin to navigating uncharted waters. Among these theories, the extended mind theory emerges as a beacon, illuminating the path towards a deeper comprehension of human cognition, consciousness, and the intricate interplay between the mind and the body. This chapter embarks on a multifaceted journey, guided by the desire to dissect the extended mind theory and unearth its profound significance, drawing from the realms of philosophy, psychology, and physics to provide a comprehensive and multidisciplinary perspective. The extended mind theory, a brainchild of philosophers Andy Clark and David Chalmers, is anything but conventional. It challenges the established boundaries of cognitive processes, shattering the chains of Cartesian dualism that have long dominated the discourse. In essence, it proclaims that the mind, rather than being an isolated entity, is intrinsically linked to and interwoven with the world it interacts with.
Indigenous Rodhi Culture of Gurung and Factors of its Transform at Ghandruk Kaski in Nepal
Authors: Panta Saroj Raj
Published: December 2023

The Rodhi, a traditional cultural practice in Nepal, has lost its native form in recent years. It was popular in the Gurung community in Ghandruk, however, it is being transformed into a modern form popular in restaurants. This decline in native Rodhi is attributed to factors such as globalization, modern entertainment tools, and the shift from agriculture and animal rearing to films and dance bars. The study used qualitative data collection methods and an ethnographic study to analyze the changes in Rodhi culture. Twenty-seven participants were selected for the study, and data was collected through interviews, observations, narratives, discussions, and case studies. The findings revealed that modern entertainment tools, such as films, dance bars, Hindi and English films, hybrid music, and contemporary songs, have diverted the audience and participants from Rodhi's originality to youths. Globalization has led to cultural assimilation, with Gurungs being enlisted in services in Singapore police, Brunei reserve troops, French, British, and Indian armies have less prioritized Rodhi. Globalization encourages immigration, contemporary communication, mass media, overseas employment, cultural assimilation, and shifting traditional occupations. Cultural assimilation due to globalization confined Rodhi to nightclubs, affecting the traditional language and Rodhi culture among the Gurung community of Ghandruk. Cultural assimilation and socio-cultural effects contribute to the declination of traditional knowledge, local culture, and cultural identities like Rodhi. This study has implications for the preservation and promotion of traditional culture, benefiting cultural practitioners, activists, academicians, future researchers, and policymakers.
Bhandari, P. (2020). Matchmaking in Middle Class India: Beyond Arranged and Love Marriage. Springer.
Authors: Aryal CP
Published: December 2023

Match Making
Editorial Notes
Authors: Khattri Man Bahadur
Published: December 2023

Editorial Notes
Correlation Between Teeth Alignment and Oral Diseases in New India
Authors: T.A. Deepak , Tejasvi M.L. Avinash
Published: December 2023

Systemic Health goes together with oral health. In India, Oral health remains a big challenge. It is connected tightly to overall individual’s health. Basic oral hygiene such as brushing teeth twice a day is still foreign to most, while such practices are widely practiced in the west. In India, economic factors, coupled with normally accepted behavior and acceptance of poor oral hygiene, prevention of awareness contributed to vast populace with dental issues, like cavities, gum diseases, premature teeth loss, and oral cancers in some cases. With almost 60% of 1.4 billion living in rural areas, initiatives like oral hygiene awareness, preventative care, lifestyle changes and increased dental facilities including universities, colleges and dental care facilities are needed today.

We investigate whether there is an association between awareness of teeth alignment, good oral health to overall systemic health. We developed a questionnaire for dental patients falling between the age of 13 - 21 years. This range was selected as most of the patients are old enough to know their oral habits, and other health issues. The patient’s data was collected over a range of 8 months (April 2023 to November 2023) between two states in southern India. The research had 191 patients who were from rural areas, and their awareness on oral hygiene activities were found to be far worse than their urban counterparts (both genders). Based on the data collected, we establish a close relationship between awareness of teeth alignment, to gum bleeding, caries, and pollinosis in young Indians.

Int. J. Appl. Sci. Biotechnol. Vol 11(4): 209-216.
Assessment of Riverbank Erosion and Accretion and its Impact on the People of Chairman Ghat, Noakhali, Bangladesh
Authors: Mou Momotaj Ara , Tusar Md. Kamruzzaman , Haque Md. Riyadul , Chakraborty Shemoul , Ahmed Sajib
Published: December 2023

Nestled within the vastness of the Meghna deltaic plain, Noakhali, and in particular, Chairman Ghat, stand as poignant examples of Bangladesh's intricate relationship with environmental challenges. The significance of the Meghna deltaic plain cannot be overstated, as it shapes the very fabric of the nation's landscape. However, this geographic richness comes hand-in-hand with vulnerability, and nowhere is this more apparent than in the relentless grip of riverbank erosion. Chairman Ghat, in Noakhali, epitomizes the struggle against this natural force, making it a focal point for understanding and addressing the profound impact of riverbank erosion in the region. The primary objective of this research work is to assessing river bank erosion & accretion and examine its the potential impact in the chairman Ghat area. In order to achieve this goal, this study employs remote sensing and GIS techniques to assess the erosion and accretion rates of Chairman Ghat on the Noakhali coast from 2000 to 2022 and conduct household survey to examine the socioeconomic impacts of river erosion on the local population. The findings revealed that Over the past 22 years, the Meghna estuary experienced a total of 667.0 km2 of erosion and 689.1 km2 of accretion. Chairman Ghat area alone witnessed a net erosion rate of 4.2 km2 per year during the specified period, resulting in a loss of 117.7 km2 of land, while only 25.3 km2 of new land was added.  From household survey it is found that the adverse effects of riverbank erosion on the local community are evident, leading to the loss of vital agricultural lands, homesteads, and property damage that cannot be easily recovered. Consequently, a significant portion of the affected population is compelled to migrate, thereby exacerbating their socio-economic plight as they are forced to change professions. This research sheds light on the extent of riverbank erosion in Chairman Ghat, Noakhali, and elucidates its profound socioeconomic implications on the lives of the local inhabitants. The findings of the study will help to enhance our understanding of the specific impact of river erosion enabling the development of targeted strategies to protect vulnerable communities' lives, livelihoods, and environments. It will also promote cohesive coastal zone management, implementing robust measures that counteract the destructive consequences of riverbank erosion, thereby ensuring the sustainable development and resilience of these crucial ecosystems.
Impacts of Climate Change and Land Use Change on Streamflow: A Case of Seti Gandaki Watershed, Nepal
Authors: Baral Kushal , Pandey Vishnu Prasad , Pradhan Ananta Man Singh , Khanal Avishek
Published: December 2023

Recent research and IPCC reports extensively document the varied effects of climate change on basins worldwide. This study evaluates the impact of climate change and land use change on the Seti-Gandaki watershed's hydrological regime of Nepal. Using a calibrated hydrological SWAT model, forced with climate scenarios (SSP245 and SSP585), the study projects increased precipitation (2-129% and 3-139%) and a warming trend in temperature. Streamflow at the watershed’s outlet is expected to rise (up to 49% in monsoon, 96% in winter in SSP245; up to 61% in monsoon, 89% in winter in SSP585), with increased flow extremes, potentially leading to floods and landslides. The combined impacts project a 52-125% increase in streamflow in SSP245 and a 100-136% increase in SSP585, attributed to the shift from rural to urban settlements. These findings provide crucial insights for water resource planners and managers to develop location-specific strategies for sustainable water resource use in the Seti-Gandaki Watershed.
An Analysis of the Determinants of Bank Stability in the Banking Industry of Nepal
Authors: Gwachha Krishna Prasad
Published: December 2023

Bank stability refers to the ability of a financial institution to maintain consistent and secure operations, even in the face of economic challenges or shocks. This research study examines the determinants of bank stability in the Nepalese banking industry. The study analyzed data from commercial banks over a wide time range from 2001 to 2023, utilizing the autoregressive distributed lag (ARDL) model technique. The study found that bank size, funding risk, liquidity risk, and GDP growth have a positive and significant impact on bank stability in Nepal. The study also found that credit risk has a negative impact on bank stability. This implies that higher levels of credit risk increase the likelihood of bank instability in Nepal. Banks must give utmost priority to effectively managing and controlling bank size, funding risk, liquidity risk, and fostering GDP growth in order to bolster bank stability and fortify the country's financial system. However, the study also found that credit risk has a negative impact on bank stability. This implies that higher levels of credit risk increase the likelihood of bank instability in Nepal. The implications of the research study for policymakers, regulators, and banks, emphasize the need for effective risk management practices, adequate capitalization, diversified funding sources, and a supportive economic environment to ensure a stable banking sector. The implications of this finding hold great importance for policymakers, as they highlight the crucial role of preserving current bank stability in order to attain even greater stability in the future.
Evaluation of Phenological and Pomological Characteristics of Plum Varieties (Prunus spp. L.) in Mustang, Nepal
Authors: Kafle Santosh , Atreya Padma Nath , Timilsena Ram Hari , Pokharel Prayan , Khatri Sushil , Adhikari Biju , Bhandari Niraj
Published: December 2023

Plum is a temperate stone fruit widely adapted and is by far the most diverse of all the 'Prunus' species. However, fruit and flower phenology and pomological characteristics differ among varieties. Phenological and pomological characteristics of six plum varieties ('Soldam,' 'Mirabelle,' 'Quetsche,' 'Methley,' 'Santa Rosa,' and 'Local') during September 2021-August 2022 in the fruit orchard of Temperate Horticulture Development Center, Mustang, Nepal, were studied. The phenological study revealed the Local as early and Quetsche as late among the tested varieties. However, the average flowering duration was lowest in Methley (10.6 days) and highest in Soldam (15.2 days). Linear dimensions of the fruits were maximum in Soldam and minimum in Mirabelle. The fruit shape of all the varieties was round except for Quetsche, which was elliptic. The stone share was highest in Mirabelle (7.82%) and lowest in Soldam (1.86%). The ripening index was highest for Mirabelle (29.11) and lowest for Methley (7.20). The organoleptic evaluation revealed that Soldam was the most preferred while Quetsche was the least.

In conclusion, our study showcased a significant diversity in plum varieties, with implications for orchard management and variety selection to cater to various preferences and needs in the local market and beyond.
Evaluation of Sweet Pepper Genotypes for Yield and Quality in Open Field Using Plastic Mulch in Mid Hill Condition of Nepal
Authors: Poudel Sujata , Gautam Ishwori Prasad , Shrestha Surendra Lal , Ghimire Dipendra , Dhakal Mira , Pandey Suprabha , Subedi Sujan , Regmi Rajendra
Published: December 2023

Sweet pepper is an emerging high value vegetable crop. There are few numbers of varieties recommended in Nepal despite of having immense commercial farming potentiality. An experiment was conducted during 2020 and 2021 at National Horticulture Research Centre, Khumaltar, in open field condition to identify high yielding capsicum genotype with longer postharvest shelf life. The field experiment was done by using the Randomized Complete Block Design (RCBD) with four replications for each treatment and the lab experiment for postharvest shelf life was studied in first year using Completely Randomized Block Design (CRD) with three replications for each treatment. The six elite capsicum genotypes under study were HRDCAP-001, HRDCAP-003, HRDCAP-004, HRDCAP-005, HRDCAP-006, and California Wonder (standard check variety). The research plot was mulched with 25-micron plastic and 4-6 leaf stage seedlings transplanted making holes in mulch at the spacing of 60 cm x 45 cm. Among the tested genotypes, HRDCAP001 and HRDCAP005 were found to be promising in terms of fruit length, fruit weight, yield per plant and yield per hectare followed by HRDCAP006 during a two-year experiment. The genotype HRDCAP001 was rich in vitamin C content with less spoilage loss while HRDCAP006 was observed most fresh followed by California Wonder and HRDCAP001 respectively. Overall, the genotype HRDCAP001 was found to be the superior among all the genotypes in terms of yield and quality parameters. However, a multi-location farmer’s field trial should be conducted for further verification and varietal development purpose.
Need for evidence synthesis for quality control of healthcare decision-making
Authors: Sathian Brijesh , Van Teijlingen Edwin , Do Nascimento Israel Junior Borges , Khatib Mahalaqua Nazli , Banerjee Indrajit , Simkhada Padam , Kabir Russell , Al Hamad Hanadi
Published: December 2023

Systematic reviews that are out-of-date delay policymaking, create controversy, and can erode trust in research. To avoid this issue, it is preferable to keep summaries of the study evidence. Living evidence is a synthesis approach that provides up-to-date rigorous research evidence summaries to decision-makers. This strategy is particularly useful in rapidly expanding research domains, uncertain existing evidence, and new research that may impact policy or practice, ensuring that physicians have access to the most recent evidence. Addressing global challenges – ranging from public health crises to climate change or political instability - requires evidence-based judgements. An obsolete, biased, or selective information poses risks of poor decisions and resource misallocation. The relatively nascent practice of living evidence proves invaluable in maintaining continuous interest and team engagement. The concept of living evidence has been particularly relevant during the COVID-19 pandemic due to the rapidly evolving nature of the virus, the urgent need for timely information, and the continuous emergence of new research findings. Although the COVID-19 pandemic accelerated the adoption of evidence systems, researchers and funders of research should rigorously test the living-evidence model across diverse domains to further advance and optimize its methodology.
Study of the cultural identity: use of Mongolian Calligraphy
Authors: S. Gantsetseg , B. Enkhzul , T. Sumiya , N. Ariunaa , T. Oyun-erdene , B. Enkhmandakh
Published: December 2023

Mongolian National Calligraphy is one of the Intangible Cultural Heritages in Need of Urgent Safeguarding of Mongolia that is registered in UNESCO and claimed as a valuable heritage in the project “Mongolian Values”. Therefore, increasing the use of calligraphy is very crucial for maintaining cultural immunity. The research was focused on determining the modern use of Mongolian Calligraphy based on the historical development and its contemporary situation. The data were collected from 300 respondents as general, casual and key informants through questionnaires and in-depth interviews. The questionnaire result has been analyzed both in the SPSS program and in MS Excel Formula Section and confirmed by the experts in linguistics. The final result was interpreted based on the descriptive method. The research result suggested that Mongolian National Calligraphy should be studied at the scientific level and disseminated in public. Therefore, there is a need to integrate multilateral cooperation into a common policy in order to surge the further use of Mongolian National Calligraphy.
Dynamic Relationship of the Stock Index with the Trading Volume of the Nepal Stock Exchange: An Empirical Analysis
Authors: Kadel Dhaka Ram , Patodiya Pawan Kumar
Published: December 2023

Knowledge about the linkage between the volume and the index of the stock is crucial for market participants and investors to make informed decisions in trading and forecasting the stock market, as understanding this fundamental Linkage enhances investment decisions. This study relies on time series data to objectively explore the dynamic linkage between the index of the stock and the amount of trade on the Nepal Stock Exchange from mid December 2018 to mid-January 2023. The outcome of the Autoregressive Distributed Lag (ARDL) model reflects a long- and short-term substantial positive association between the volume of the trade and returns from the stock in the current timeframe. This implies that a change in volume has both a long- and short-term, small but positive effect on the returns from the stock. Conversely, the lagged-period stock index negatively and significantly impacts the present index of the stock. However, the conclusions drawn from the Granger causality test demonstrate no Granger causation from the volume of the trade to return and vice versa, implying that both variables do not affect each other.
Job Satisfaction of the teachers in Kathmandu Metropolitan City
Authors: Bajracharya Pradip
Published: December 2023

This article explores the satisfaction of the teachers who are working in different public and private schools in Kathmandu Metropolitan City. The article aims to identify the factors that satisfy the teachers so that they retain in the school for a longer period of time. The participants of this study were purposively selected. Collecting questionnaires as the means of data generation, this article finds out insights from 194 teachers who have been in the teaching field for more than a year. Most of the teachers found enjoyment in their work, regardless of government, private or community schools. They pointed out the importance of the role of the supervisor as well as the opportunity to attend the training in the job satisfaction. The research shows that overall enjoyment of job depends on the satisfaction with the benefits provided to the respondents.