bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of the fungicidal efficacy of photodynamic therapy with methylene blue, silver nanoparticle, and their conjugation on oral Candida isolates using cell viability assay
Authors: Lavaee Fatemeh , Badiei Parisa , Yousefi Motahareh , Haddadi Pardis
Published: April 2021

Background and Purpose: This study aimed to evaluate the effect of common photodynamic therapy and photodynamic therapy by the silver nanoparticle, methylene blue, and their combination on biofilm and plankton cells of standard oral Candida isolates using cell viability assay.
Materials and Methods: In this in vitro study, biofilm and plankton cells of Candida species(i.e. C .albicans and C. parapsilosis) and plankton cells of Candida glabrata were treated with methylene blue, silver nanoparticle, and their combination once alone and then with the irradiation of total dose of 1.92 J/cm² for 60 sec. The minimum inhibitory concentration and antifungal activity of each approach were evaluated using the XTT assay.
Results: After photodynamic therapy, methylene blue showed antifungal effect only on Candida albicans, while the antifungal effect of silver nanoparticles was increased on all Candida species. On the other hand, photodynamic therapy with the combination of methylene blue and silver nanoparticles did not have any effect on C. albicans. However, it reduced the minimum inhibitory concentration value of C. parapsilosis, and the most antifungal effect was observed on C. glabrata.
Conclusion: Photodynamic therapy with photosensitizers can serve as a treatment modality in Candida infections of the oral cavity. Antifungal effect of photodynamic therapy was strain- and photosensitizer-dependent.
Mucormycosis: Literature review and retrospective report of 15 cases from Portugal
Authors: Prista-Leao Beatriz , Abreu Isabel , Claudia Carvalho Ana , Sarmento Antonio , Santos Lurdes
Published: April 2021

Background and Purpose: Prevalence of mucormycosis is growing with the increase of the population at risk. Current recommendations for its management are mostly based on retrospective studies. 3 study aimed to present the cumulative experience of an Infectious Diseases Department from a Portuguese hospital in the management of mucormycosis and discuss the potential gaps in the diagnostic and therapeutic approaches of this infection.
Materials and Methods: For the purposes of the study, the electronic hospital database was searched for adult patients with mucormycosis from 1996 to 2019 based on the definition provided by the Consensus Definitions of Invasive Fungal Disease. Demographic, clinical, treatment, and outcome data were collected and compared to what had been described in the related literature.
Results: In total, 15 cases of mucormycosis were found, including 11 cases with sinus involvement (10 with central nervous system involvement), two pulmonary, and two gastrointestinal infections. Diabetes mellitus (n=7) and corticosteroid therapy (n=7) were frequent risk factors. Median duration of symptoms before the suspicion of diagnosis was 26 days (3-158). The diagnosis was confirmed in 12 patients mostly by histopathology (n=9); the culture was positive only once. Systemic antifungals and surgical debridement were the backbones of treatment; however, side effects, the need for therapeutic drug monitoring, and the anatomical location of lesions added complexity to management. Overall, seven patients died, two of them before the consideration of clinical suspicion.
Conclusion: More medications are becoming available for the treatment of mucormycosis. Nevertheless, we believe that its prognosis will only significantly change through the increase of awareness and reduction of the time to diagnosis. An effective multidisciplinary approach among surgeons, infectious diseases specialists, radiologists, microbiologists, and anatomopathologists is critical to the achievement of this goal.
Bio-protective Effects of Lactobacillus Plantarum subsp.plantarum Against Aflatoxin B1 Genotoxicity on Human Blood Lymphocytes: A Native Probiotic Strain Isolated FromIranian Camel Milk
Authors: Afshar Parvaneh , Roozbeh-Nasiraie Leila , Shokrzadeh Mohammad , Ghorbani-HasanSaraei Azade , Naghizadeh-Raeisi Shahram
Published: April 2021

Background and Purpose: Aflatoxin B1 is one of the main poisonous substances in certain kinds of fungi all over the world. The toxin is a serious health threat to humans and livestock, particularly via DNA damage, and induces multiple cancers. Probiotic agents have confirmed positive beneficial effects in DNA protection against various toxic compounds. In this regard, the present study aimed to investigate the bio-protective effects of a native Lactobacillus plantarum subsp. plantarumNIMBB003 strain isolated from Iranian one-humped camel milk against AflatoxinB1 (AFB1)-induced genotoxicity damage, based on the micronucleus test as a genotoxicity monitoring method.
Materials and Methods: In this study, a human male blood sample was treated and incubated with107, 109, and 1011CFU/mL of viable L. plantarum and IC50 dose ofAFB1alone and in combination. Afterward, assessed the rate of production of the micronucleus in bi-nucleated lymphocytes. It must be noted that a p-value of less than0.05 was considered significantly significant.
Results: Based on the findings, the combined treatment of the L. plantarum at 1011 and109CFU/mL dose with 5.33±0.57% of the micronuclei fragments had protective effects and significantly decreased the genotoxicity of AFB1 by 76%.
Conclusion: According to the findings, it can be concluded that L. plantarum in 109 CFU/mL had high protective potency against AFB1 genotoxicity. Consequently, the use of local, natural, and native protected compounds with antioxidant effects, such as probiotics agents, is one of the objectives of developing a green strategy in macro-management policies for the discovery and production of new medicines and functional foods with protective/therapeutic effects against nutritional and endogenous DNA toxins.
Numerical estimation of the one-dimensional consolidation behavior of clay
Authors: Uysal Firdevs , Sivrikaya Osman
Published: April 2021

The consolidation behavior of clayey soils is traditionally evaluated in the laboratory using the one-dimensional consolidometer test. A new oedometer cell design with a ring of 60 mm in height, 75 mm in diameter was made to measure the excess pore-water pressure at the undrained base of the specimen and the friction between the soil and the ring, and to determine the ε – log p curve. This study deals with numerical modeling of the one-dimensional consolidation test and comparing the data obtained from the experimental study with the data from the modeling. In the modeling, the Soft Soil and Soft Soil Creep models were used for the clay proposed in this study. The results show, as a general trend, that the data from the numerical modeling are compatible with those from the experimental study.
Digital strategic initiatives: conceptualization and illustration
Authors: Piccoli Gabriele , Rodriguez Joaquin
Published: April 2021

This essay responds to calls for discerning so-called IT “x” and digital “x” phenomena. Research in this area promises to make an important contribution since the emergence of digital “x” labels runs the risk of diluting the core of IS literature. Our paper advances a preliminary definition of key constructs: digital strategic initiatives and digital resources, differentiating the latter from traditional conceptualizations of IT or IS resources. It also delineates two different approaches to the execution of digital strategic initiatives: a) orchestration of digital resources and b) creation of novel digital resources. We demonstrate the first one with a case illustration of home grocery delivery and the second with the case of a dark kitchen provider in the restaurant industry.
Regtech opportunities in the platform-based business sector
Authors: Clarke Roger
Published: April 2021

The notion of RegTech has emerged in recent years, but its application appears to have been mostly limited to the use of technology to assist with organisations' compliance with regulatory requirements. A model is presented that encompasses RegTech's full scope, embracing its capacity to address the needs not only of regulatees, but also of regulators and the intended beneficiaries of regulatory regimes. The model is then applied to the recently-popularised platform-based business model, whose mature form is evidenced by Uber and Airbnb. A range of opportunities is identified for practitioners and researchers to contribute to the application of information technologies in the regulatory space.
Perceived limitations of telemedicine from a phenomenological perspective
Authors: Knop Michael , Mueller Marius , Freude Henrik , Ressing Caroline , Niehaves Bjoern
Published: April 2021

In the course of healthcare digitization, the roles of therapists and patients are likely to change. To shape a theoretical based process of technological transformation, a phenomenological perspective on Information and Communication Technology (ICT) is introduced. Therefore, this paper illustrates the benefit of a holistic view on patients and therapists to describe and explain phenomena concerning Human Technology Interaction (HTI). The differentiation between a measurable objective body and a habitual subjective body helps to evaluate and anticipate constituting factors of accepting telemedicine systems. Taking into account findings from a secondary analysis of semi-structured interviews we conducted with primary care physicians, we develop a phenomenological framework for HTI in healthcare. Our aim is to structure future research concerning design implications for ICT and the implementation of telemedicine systems in clinical and primary care.
Effect of grain size distribution on the maximum and minimum void ratios of granular soils
Authors: Duque Jose , Fuentes Lacouture William Mario , Barros Ayala Jorge Andres
Published: April 2021

The maximum and minimum void ratios define the loosest and densest conditions of a granular soil. Correlations with some granulometric properties of soil are of interest for practical applications, but the experimental procedure to determine these variables can be time consuming. In this work the influence of the grain size distribution on the maximum and minimum void ratios is investigated. Twenty different granular soils with varying grain size distributions were prepared and tested. The experimental results, together with a compilation of 56 additional results reported in the literature, are statistically analysed. The analysis is conducted to examine the influence of some granulometric properties (D10, D30 and D60) on the maximum and minimum void ratios. As a result, some correlations considering the aforementioned variables are proposed. Subsequently, it is shown that the proposed correlations have better agreement with the experimental data than other proposals reported in the literature. The paper ends with some concluding remarks.
Forgotten Nature? Experiences with and Knowledge of Nature Among Schoolchildren: A Pilot Study in Central Switzerland
Authors: Kühnis Jürgen , Fahrni Désirée
Published: April 2021

This pilot study investigates the extent of familiarity among primary school children (6th grades, n = 142, 55.6 % boys) with common local animal and plant species and whether this knowledge differs depending on selected context variables. As the analysis shows, nature is of great importance, and most children already have gathered some basic experience of nature. On average, they correctly identified 51.2 % of the animals and 36.2 % of the plants, but there were obvious gaps in their knowledge. The present results showed a clear connection between the knowledge of native animal and plant species depending on the child’s nationality, whether they have a garden at home and how their parents stimulate their interest in nature.
Entrepreneurship and the Education of Future Teachers
Authors: Stamatović Jelena , Zlatić Lidija
Published: April 2021

Modern education needs include teachers who possess entrepreneurial competences. The subject of our study is entrepreneurship education in the field of teaching. We conducted semi-structured interviews with senior students of the Faculty of Education in Uzice (N=70). Entrepreneurship education can be realised using formal, non-formal and informal methods in higher education. The fundamentals of entrepreneurship are already represented in the existing curriculum, which cannot be deemed sufficient for systematised knowledge of entrepreneurship. Therefore, faculties of teacher education must be open to new models of activity and content organisation aimed at the development and encouragement of entrepreneurial competences among future teachers.
Effect of Yeast Type and Dose on Growth Performance and Nutrient Digestibility of Growing Rabbits Fed Maize or Barley
Authors: Elmasry Amr M.A. , Miranda Luis A. , Mendoza Germán , Plata Fernando X.
Published: April 2021

Background: The effects of the probiotics vary with the doses and strains used for this reason, a study was conducted over 35 days to determine the effect of live yeast supplementation in the diet of growing rabbits on growth performance and apparent nutrient digestibility. Methods: A total of 60 New Zealand and California rabbits (5 weeks old, average body weight 0.881±0.015 kg) were housed in 30 cages. They were fed with a control diet based on alfalfa and maize or barley grains and supplemented with Procreatin®7 (Saccharomyces cerevisiae CNCM I 1077) or Biosaf® SC47 (Saccharomyces cerevisiae NCYC Sc47) at three doses, namely 0, 6.4, or 12.8 ×109 CFU per kg basal diet. Result: The higher yeast concentration had a positive effect (P less than 0.01) on final body weight (BW), average daily gain (ADG) and carcass weight (CW). However, there were no significant differences in dry matter intake. As a result of this, the feed conversion ratio (FCR) decreased (P less than 0.01). Significant increases (P less than 0.05) in nutrient digestibility (DM, OM, NDF and ADF) were observed with both grains. The use of yeast in maize and barley-based diets of rabbits has positive effects on growth performance and nutrient digestibility.
El ciclo hidrosocial del río Atuel en el contexto extractivista (1987-2018) en las provincias de Mendoza y La Pampa, Argentina
Authors: Langhoff María Laura , Rosell Patricia , Geraldi Alejandra
Published: April 2021

El presente trabajo se propone abordar, desde el enfoque de la ecología política del agua, el conflicto entre las provincias de La Pampa y Mendoza, en Argentina, por el río Atuel, ante el inicio de actividades extractivistas como el fracking. Se utiliza el concepto de ciclo hidrosocial, el cual considera cómo interviene la sociedad en la circulación del agua. El objetivo es analizar los hechos más trascendentales en los últimos 40 años del ciclo hidrosocial (1978-2018) y las propuestas de arribar a una solución al conflicto. La metodología utilizada es de carácter cualitativo y parte de la aplicación del método del sándwich de Dagwood, propuesto desde la geografía histórica, el cual consiste en el trabajo de un tema central a través de períodos de tiempo. Para la recopilación de información se trabajó con entrevistas y revisión bibliográfica. Los resultados obtenidos condujeron a la identificación de una profundización de la complejidad de los procesos extractivos en la subcuenca del Atuel y la participación de nuevos actores como el capital trasnacional y las asambleas socioambientales. Como conclusión, se expone la necesidad, sobre todo de parte de La Pampa, de considerar la presencia de nuevos actores y actividades vinculados a actividades extractivistas y su influencia tanto en el conflicto como en sus posibilidades de resolución.
Ordenamiento territorial y conflictos socioambientales vinculados a la minería: provincias de Huasco y Chubut en defensa del territorio
Authors: Mora Castillo María Alejandra , Alvarez Manriquez Lorena Vanesa
Published: April 2021

En las últimas décadas, se ha producido un aumento de los conflictos socioambientales en torno a la minería en América Latina como producto del impacto del modelo extractivista en las comunidades locales. A raíz de ello se han generado diferentes repertorios de acción colectiva en torno a dichos conflictos, cuyo origen no solo es producto de políticas macroeconómicas, sino que también están amparados en una institucionalidad territorial y ambiental que favorece la intervención de actores económicos externos. El objetivo de este artículo es analizar las implicaciones de las políticas de ordenamiento territorial en los procesos de conflictividad socioambiental a partir del estudio de dos conflictos mineros, uno en la provincia de Huasco, en Chile, y el otro en la provincia de Chubut, en Argentina. La metodología incorporó un reconocimiento de las características de los territorios que se complementó con una búsqueda documental sobre el desarrollo del conflicto, los actores y las normativas ambientales y territoriales vigentes en ambos países. Los resultados presentados son parciales y fueron desarrollados en el marco de un trabajo mayor de investigación. Como conclusión, se plantea que el ordenamiento territorial no solo es un instrumento de planificación, sino un proceso para articular intereses y territorialidades, generalmente opuestas, que en tanto más consideren una lógica participativa de los diferentes actores que ocupan el territorio, más sentido cobrará para quienes lo habitan.
La evaluación de las prácticas profesionales de coenseñanza
Authors: Arriagada Carlos Roberto , Venegas Natalie Gislaine , Calzadilla-Pérez Oscar Ovidio
Published: April 2021

La coenseñanza es una estrategia reconocida internacionalmente por sus potencialidades en el desarrollo profesional docente y en el aprendizaje de los estudiantes, que implica considerables transformaciones en el aula escolar. El Ministerio de Educación chileno implementó esta estrategia mediante los Programas de Integración Escolar, al señalarla como una herramienta para la mejora de la calidad de la educación. En consecuencia, este trabajo centra su objetivo en la evaluación de las prácticas de coenseñanza por medio de un estudio descriptivo y mixto que se apoya en la entrevista y el grupo focal. Este último se convirtió en un escenario de comprensión y reflexión sobre la gestión pedagógica y curricular de los docentes a propósito de las prácticas de coenseñanza. A partir de esta evaluación, se identificaron tanto dificultades en el área de gestión del tiempo para la preparación de la enseñanza como la prevalencia del trabajo aislado por parte del docente de aula y del educador diferencial. Las acciones de mejora instrumentada fortalecieron el liderazgo pedagógico, el diseño de la enseñanza, las relaciones interpersonales, el desarrollo profesional docente y el aprendizaje de los estudiantes.
Relación entre gestión de la calidad total y desempeño de las empresas Mypes exportadoras de quinua, Perú 2020
Authors:   , Raymundo Bautista Kattya , Paucar Espíritu Melissa Lucero
Published: April 2021

La propuesta principal del estudio parte por “sugerir la implementación de un procedimiento estandarizado para mejorar la gestión de importaciones en Syrsa SAC”, estudio que tiene como principal objetivo analizar como un procedimiento estandarizado mejorará la gestión de importaciones en SYRSA SAC. En el aspecto metodológico el alcance es explicativo ya que estuvo dirigido a responder por las causas de los eventos y fenómenos físicos o sociales.
The effectiveness of cytocardioprotection of patients with the moderately expressed post infarct dysfunction of left heart ventricle: the results of the randomization research of trimetazidine and athenolole
Authors: Kalyuzhin V. V. , Solovtsov M. A. , Kamaev D. U.
Published: April 2021

With the purpose of research of clinical efficiency of trimetazidine and atenolol and their influence on morfofunctional parameteres of left ventricle 36 men who have transferred a myocardial infarction are inspected. Patients were randomly divided into 2 groups. Clinical status and function state of left ventricle (by echocardiography) was assessed before and after 4-week therapy with trimetazidine or atenolol. Atenolol and trimetazidine have shown in our study identical clinical efficiency. However while atenolol is statistically significant reduced systolic arterial pressure and heart rate, thickness of posterior wall of left ventricle and corrects diastolic function, trimetazidine had no such activity. Treatment with trimetazidine promoted improvement of local contractility of left ventricle.
The clinical manifestations of nervous system mesenchyme syphilis
Authors: Valikova T. A. , Alifirova V. M. , Fyodorova I. M. , Paimursina N. Yu.
Published: April 2021

Nervous system syphilis — neurosyphilis (NS) belongs to rather rare diseases. According to the different authors data available it comes to about 1% of the nervous system organic disturbances and develops by 5—10% syphilous patients not having been treated in the acute stage of the pathological process. The syphilitic disturbance of the nervous system is a chronic progressive disease caused by the pale spirochaeta. The nervous system disturbance occurs basically in two ways: secondary one, because of brain shells, vessels, gummatous manifestations involving in the pathologic process; or primary one, when the causative agent affects directly the brain substance. In the first case syphilis is called rnesodermic or early one; in the second case — parenchymatous or late, primary one. In the article the analysis of two clinical cases of mesenchyme neurosyphilis is carried out: latent neurosyphilis and syphilitic meningomyelitis. Neurosyphilis classification is applied to clinical manifestatons of syphilitic arachnoiditis and vasculitis are described. The methods of specific and nonspecific therapy of mesenchyme syphilis are stated in detail.
The role of herpes-virus infection and mixed infection in atopy
Authors: Ogorodova L. M. , Kozina O. V.
Published: April 2021

An observative study of infectionary risk factors (simple herpes virus, toxoplasm, cytomatagalovirus, helminths, candida, staphylocoque, listeriosis) in reagine immunopathological reactions development has been undertaken in a basic group of 3183 patients. In the study the «case-control» method of populate investigation was being used. The patients of representative sample (293 persons) with atopic diseases have been investigated for specific antibodies for these diseases and IgE antibodies. The study results in a statistically trustworthy association between the simple herpes infection, cytomatagalovirus, helminths and candida infections, the IgE hyperproduction, and a numeral increase both of patients with combined forms of atopy and of accompanying diseases. The aforesaid makes us refer these infections to the risk factors causing infavourable development of atopic diseases. In the contrary, helminths infection in atopic patients correlates with decrease of IgE production that in general approves the so-called «hygienic hypothesis».
Tomsk School of immunology. Life and create of scientist and citizen. (To 50th anniversary of academician of RAMS and RAES N.V. Vasilyev (1930—2001))
Authors: Choinzonov E. L. , Mendrina G. I. , Cherdyntseva N. V. , Klimov V. V. , Krasnozhenov E. P. , Pisareva L. F. , Smol’yaninov E. S.
Published: April 2021

The main stages of vital way, scientific and educational activities of outstanding Tomsk scientist, academician of the Russian of Medical Sciences and academician of the Ukrainian Academy of Ecological Sciences have been presented. Nikolai Vladimirovich Vasilyev was the head of Tomsk School of immunologists. He contributed greatly to the development of non-infectious immunology, especially to oncoimmunology and ecologic immunology. His fundamental scientific developments and hypotheses continue to be the base for scientific investigations of his followers.
To the 80th jubilee of Tomsk scientific research institute of balneology and physiotherapy
Authors: Golosova L. O. , Shustov L. P. , Peven N. N.
Published: April 2021

In the article the history of creation of Tomsk scientific research institute of balneology and physiotherapy, the names of its grounders are presented. Key events in the history of its development are discovered. Major directions of scientific and practical activity, perspectives of development are defined.
80 years since the foundation of pathological physiology department at Omsk state medical academy
Authors: Dolgikh V. T. , Matusov I. E. , Taran N. I.
Published: April 2021

The materials focused on formation and development of pathological physiology department at one of the oldest medical institutes in West Siberia are available in the article. The main trends of scientific research and the results of bringing elaborations into public health practice are described. The authors report base and clinical pathological physiology teaching peculiarities and enumerate text-books published by members of the department staff. The paper is a brief review of former members of the department staff who have placed at the head of scientific research institutes, pathological physiology departments in different cities of Russia afterwards.
The complex successive rehabilitation of children with consequences of perinatal lesion of nervous system
Authors: Krivonogova T. S. , Paramonova G. F. , Tropova T. E. , Matveeva L. A.
Published: April 2021

The aim of the study was to estimate the influence of rehabilitation measures on physical growth and cognitive functions in preschool children.

We examined 224 children from 4 to 7 years old and in 197 (88%) of them revealed high level of health deviations. The most frequent were cervical insufficiency and bearing abnormality, of general and delicate motions, speech abnormalities. All children underwent cognitive functions checkup. In this connection we tilled the complex of rehabilitation measures for the children with physical growth and cognitive functions abnormalities. The efficacy of rehabilitation measures was estimated 3 years later.
The history of preparation of medical staff in the territory of Tomsk region (pre-Revolutionary and Soviet period)
Authors: Mochalina L. A.
Published: April 2021

The history of development of medical service and preparation of medical staff in the territory of Tomsk region is presented. The first hospitals of Tomsk are listed, the names of their establishers are underlined.
Arrangement of risk group with congenital fetus pathology using artificial neural nets
Authors: Philippov O. S. , Kazantseva A. A.
Published: April 2021

The aim of the study is the evaluation of the significance of various risk factors for congenital fetus pathology (congenital defect – CD) and the development of risk numeric scale. 424 pregnant women with fetus CD and 520 pregnant women with fetus without congenital defects have been examined. Artificial neural nets have been used for investigation how various factors effect on pregnancy termination. It has been found that the important factors for congenital fetus defect risk are: age younger 18 years of an pregnant women, age older 35 years, noncarring of pregnancy in anamnesis, complicated clinical course of the first pregnancy trimester, CD cases in a family, ultrasonic markers of chromosome pathology in the first pregnancy trimester. Changes in maternal serum AFP, hCG and uE3 levels and blood flow disorders are important to forming high risk group. A numeric scale for CD risk has been developed on the basis of neuronic net analysis.
Tomsk microbiologists school (to the 100th birthday of academician S.P. Karpov)
Authors: Mendrina G. I. , Krasnozhenov E. P. , Karpova M. R.
Published: April 2021

Here is presented the history of formation of the Tomsk microbiologists scientific school, biographies of the school organizers, teachers and researchers heading the microbiology chair in different periods of its existing. The ample archival materials have been used in the article.
Radiologic diagnostics of joint affection under Lyme mite borreliosis
Authors: Zavadovskaya V. D. , Lepyekhin A. V. , Yekimova L. S. , Perova T. B. , Yekimov S. S.
Published: April 2021

The aim of investigation was a determination of ultrasonic and radioisotopic feautures of joint affection under Lyme mite borreliosis (LMB). There have been examined 84 patients by ultrasonography method and 24 patients by scintigraphy method. These patients’ diagnosis of Lyme mite borreliosis has been verified with the results of serological examinations. Changes of joint structures by arthrosonography results have been consisted of: effusion of migrating nature, joint capsule thickening, local synovial proliferation, hyaline cartilage thinning and ligamentous apparatus hardening. By radionuclide examination the greater quantity of affected joints has been revealed as compared to patient’s complaints and arthsonographic status, it has been confirmed by the further case monitoring. As a first stage of radiologic diagnostics algorithm of patients with joint affection under LMB it has been recommended the use of radionuclide examination that allowed to execute a topic diagnostics of affected joints. As a second stage it has been optimum to execute arthrosonography in order to evaluate the nature of joint affection.
Methodic approaches to the evaluation of the health of junior schoolchildren
Authors: Afanasyev Ye. A. , Vasilyev V. N. , Tyerentyeva Yu. V. , Sennikova I. A.
Published: April 2021

The results of investigation of adaptive properties at 577 children of junior school age (7—9 years old) are presented in the paper. Rise of physical growth, physical health index and adaptation level up to the 9 years has been revealed. The period of the least adaptability at girls (8 years old) has been determined. The sexual differences of the determined factors at the age of 8 and 9 years have been marked.
Instrumental diagnostics of hemocoagulation homeostasis damages during a burn shock
Authors: Shpisman M. N. , Tyutrin I. I. , Yeveskin M. Sh.
Published: April 2021

The aim of the investigation is a determination of diagnostic value of whole blood low-frequency piezoelectric hemocoagulography method (LPH) and its suitability for monitoring the homeostasis functional state during the burn shock. 40 patients with the severe thermal injury and different consequences of burn disease have been examined in development dynamics and intensive burn shock therapy with LPH method and general biochemical tests that reflected the state of vascular platelet and coagulation homeostasis and fibrinolysis components. It has been found that severe burn shock development has been accompanied by significant pathological changes in all hemostasis sections, the rate and severity of which has been connected closely with the outcome of the burn disease. The LPH method is the easiest and most informative one for monitoring the functional states of all hemostasis sections during the dynamic critical state, such as the burn shock.
Modern trends in diagnostics and treatment of gastroduodenal ulcers
Authors: Zherlov G. K.
Published: April 2021

In the lecture the modern views on diagnistics and tactic choice in the treatment of complicated and uncomplicated gastroduodenal ulcers have been presented and long-term results of organ-saving and organ-modeling surgery experience during complicated stomach and duodenal ulcers have been analyzed. Achievements in life quality saving of operated patients have been cited. Novel classifications of gastroduodenal anastomosis functional activity and anastomositis degrees have been proposed.
Emergency service system for urban population: problems and directions of perfection
Authors: Zenkin N. G.
Published: April 2021

Perfection of emergency service is one of the most important task of the structure reforming of public health protection. Currently, the main tasks are: development and application of economic mechanisms of the primary and acute medical aid control; preparation and approval of the regulation of emergency service and organization of its activity in routine and in extraordinary situations; formation of standard methodical legal foundation for optimization of the functioning of institutions, departments and emergency specialists; development of recommended models of regional programs of emergency service development and reorganization in regions of Russian Federation.
Peculiarities of cancer incidence in Tomsk region population (1990—2001)
Authors: Pisareva L. F. , Choynzonov Ye. L. , Boyarkina A. P. , Odintsova I. N. , Goldin V. D. , Martynova N. A. , Takhauov R. M.
Published: April 2021

A cancer incidence in general and in its separate nosologic forms (stomach cancer, liver cancer, cancer of lung, skin cancer, breast cancer, cervical cancer, prostate cancer, thyroid gland cancer and hemoblastosis cancer) has been studied in the population of Tomsk and Tomsk region within 1990—2001 taking into account ages and sexes. The dynamics of the cancer incidence in general and in separate forms of malignant neoplasms has been cited and the prognosis of this process up to 2007 has been done. An analysis of the main risk factors has been made.
Primary peritonitis at children
Authors: Fyodorov K. K.
Published: April 2021

In the review there are presented the modern views on primary peritonitis at children. The problems of terminology, ethiology, disease pathogenesis and classification are examined, the modern description of clinical course variants and diagnostics elements are given. The modern views on primary peritonitis treatment are presented. The bibliographic reference-book includes 123 sources issued mainly for the last 15 years.
Activity of kallikrein-kinin system at patients with asiderotic anemia
Authors: Zhilkova N. N.
Published: April 2021

The aim of investigation is to study the state of kallikrein-kinin system (KKS) and proteinase inhibitors at patients with asiderotic anemia prior to and after the treatment. 58 patients with asiderotic anemia prior to the treatment and in dynamics after 3 weeks have been examined. KKS state has been estimated by kallikrein, prekallikrein, proteinase α1-inhibitor (Pα1I) and α2-macroglobulin (α2-MG) levels in blood plasma having been investigated by Paskhina’s et al.chromatographic method and by Nartikova’s and Paskhina’s unified enzymatic method.

Patients with asiderotic anemia had the rise of KKS activity. Its change differences depending on the disease duration have been revealed. At short disease duration a regulated KKS activation and its stable state have been marked. After the treatment at patients with medium severity degree it happens a normalization of all KKS parameters, at patients with serious anemia the high activity of Pα1I persists. The continuous treatment of anemia has led to the development of pathological type activation that had persisted at patients after the treatment.

It has been revealed that the degree of KKS activation intensity and its renewal after the implemented treatment depended on the duration and severity of the disease.
Hepatic failure at obstructive parasitogenic cholestasis
Authors: Tskhay V. F. , Brazhnikova N. A. , Paramonova L. M. , Petrov L. Yu.
Published: April 2021

In Tomsk zonal hepatologic center 358 patients with obstructive parasitogenic jaundice have been operated (alveococcosis-based — 43, echinococcosis-based — 17, opisthorchosis-based — 298). Clinical presentations of hepatic failure before the surgery have been observed at 30,7% of patients, more often — under long and intensive cholestasis. Postsurgical hepatic failure has developed at 23,1%. Intraportal medicine infusions play an important role in prophylaxis and treatment of hepatic failure along with timely and optimal surgery. Infusions permit to decrease the hepatic failure progress probability from 60,6 to 30,5%, probability of suppurative complications from 10,3 to 3,1% and postsurgical lethality from 38,2 to 9,5%.
Epidemiologic investigation of the efficiency of bronchial asthma preventive pharmacotherapy (ETAC)
Authors: Fyodorova O. S. , Petrovskaya Yu. A. , Fedotova M. M.
Published: April 2021

During the last decade numerous investigations on the study of different guidelines efficiency in primary prophylaxis of bronchial asthma (BA) has been fulfilled. In the present article a publication review devoted to the analysis of the greatest population investigation (ETAC – Early Treatment of the Atopic Child) results has been presented.
Clinical pathomorphism of chronic opisthorchosis pancreatitis
Authors: Alperovich B. I. , Rodicheva N. S. , Kurysko Zh. A.
Published: April 2021

192 patients with chronic opisthorchosis pancreatitis (117 women (60,9%) and 75 men (39,1%) being under observation in Tomsk regional hepatologic center from 1970 till 2000) have been included in the protocol of retrospective cohort study. 36 patients (18,8%) have had a chronic pseudotumor-like pancreatitis. 133 patients (69,9%) have been diagnosed a chronic painful pancreatitis, 23 patients (12,0%) have been diagnosed a pancreatic cyst. Three basic forms of the chronic opisthorchosis pancreatitis have been suggested: a chronic painful pancreatitis, a chronic pseudotumor-like pancreatitis and a pancreatic cyst.
Epidemiological description of tick-borne encephalitis at children in Tomsk region and the efficiency of its prophylaxix
Authors: Pomogayeva A. P. , Karavayeva M. O. , Obidina O. V. , Guseva G. D. , Topovskaya Ye. N. , Sokerina O. A.
Published: April 2021

In this paper an epidemiological situation regarding tick-borne encephalitis at children in Tomsk region is analyzed. It is noted that Tomsk region is an endemic center of tick-borne encephalitis with cyclic variations by subareas. The total number of children with tick-borne encephalitis in the south and middle subareas is greater then in the northern subarea. The number of diseased children depended on the number of persons went to seroprophylaxis stations after the tick suction, on the tick number and duration of epidemiological season. Vaccination, accessible and free specific seroprophylaxis of the population promoted the step-by-step increase of feverish and meningeal form part and the decrease of focal tick-borne encephalitis form part.
The elected questions of condition of cellular factors of resistance during tick-borne mixed-infections
Authors: Pirogova N. P. , Karpova M. R. , Novitsky V. V. , Zima A. P. , Voronkova O. V. , Loukashova L. V. , Kologrivova Ye. N.
Published: April 2021

The authors of the article are trying to generalize the literary data that characterizing proinflammatory and anti-inflammatory cytokines production of peripheral blood immune cells during tick-borne neuroinfections: Lyme borreliosis, associated with tick- borne encephalitis. The immune response development to antigens of a tick-borne encephalitis virus and Borrelia burgdorferi in pa- tients with a mixed-infection essentially differs from those during monoinfections.
Epidemiologic situation and problems in struggle with tick-borne encephalitis in Russian Federation
Authors: Zlobin V. I.
Published: April 2021

In the end of the XXth century an uncommon increase of morbidity rate of tick-borne encephalitis was registered. Current prophylactis measures do not consider modern epidemiologic situation, which is characterized first of all by changes in the structure of the disease and main risk group, now presented by non-vaccinated urban population. For the effective struggle with tick-borne encephalitis a new strategy of prophylaxis should be introduced based on massive vaccination of population of highly endemic re- gions. Special prophylaxis with immunogobulin, acaricidic measures and personal non-specific prophylaxis though may be effec- tive, can not resolve a problem of radical decrease of morbidity rate and play a secondary role. Considering a wide spread of focuses with coexistant tick-borne-infections, immediate prophylaxis is to be based on the results of differential express diagnostics in spe- cial laboratories that should be organized in endemic regions.
Some debatable problems of tick-borne encephalitis
Authors: Komandenko N. I. , Zhoukova N. G.
Published: April 2021

The article presents the modernest sides of epidemiological of tick-borne encephalitis (TBE). In features were analysed clinical manifestitions and pathomorphosis of TBE in side soften symptomes of the infection. It presents debatable problems about seroneg- ative and chronic form of TBE and chronic containing virus—TBE in blood without manifestitions. It considers some questiones of pathogeny of differences form disease. The schemes were offered for rehabilitation patientes after TBE.
Left ventricular structural heterogeneity and myocardial remodelling
Authors: Naidich A. M.
Published: April 2021

Aimed at studying interrelation between left ventricular (LV) structural heterogeneity and myocardial remodeling, we exa- mined a group pf subjects having coronary artery disease (CAD) of several severity degree. Based on three-dimensional reconstruc-tion of LV and using original analysis methods of esophageal ultrasound investigation data, standard parameters of myocardial re-modeling ( mean values of wall thickness and short axis LV radius, interrelations of long and short semi-axes, camera volume, myo-cardial mass and its relation to the wall thickness) were scored. The assessment of heterogeneity in LV regions was performed with space resolution 4x4 mm using parameters which are characteristic of heterogeneity of the wall thickness and curvature degree and also, scale of constitution of connective material by connective tissue. Correlation analysis performed between data of LV remodel-ing and its structural heterogeneity revealed strong correlation events studied in the heart. It proved that the higher myocardial re-modeling degree the lower heterogeneity of LV. It means that myocardial remodeling process in the setting of advancing CAD de-velops to decreased scale of LV structural heterogeneity. It is suggested that heterogeneity in normal heart serves as structural basis for myocardial remodeling.
Язвенная болезнь желудка и двенадцатиперстной кишки: выбор тактики при кровотечении
Authors: Zherlov G. K. , Koshel A. P. , Vorobiyov V. M. , Yermolayev Yu. D.
Published: April 2021

Ulcerative gastroduodenal bleedings remain the actual problem of emergency surgery because of quite frequency and high mortality. The analysis of treatment results in 782 patients was conducted. There were 239 patients with gastric ulcers, 488 patients with duodenal ulcers, 37 patients with combined ulcers and 18 patients with bleeding peptic ulcers of gastroenteranastomosis. The choice of surgical policy was based on emergency fibrogastroscopy findings. According to these findings the locality and severity of bleeding were defined using J. Forrest scale. The treatment began in intensive care with obligatory endoscopic control "by the program". Emergency operations were performed in 5,9% cases and urgent operations were performed in 16.4% cases of all patients who suffered with bleeding. There were 21,7% patients with operative treatment in remote and planned order. Postoperative mortality was 3,8%. Postoperative complications were in 12,2% patients. There were consider that the treatment of ulcerative gastroduodenal bleedings should be based on the individual active and waiting policy concluding in somatic patient's condition, duration of ulcerative anamnesis, presence of gastroduodenal bleedings in the past, ulcer location, and bleeding intensity (using J. Forrest scale) and effectiveness of conservative hemostasis.
Cryosurgery of hepatic diseases
Authors: Alperovich B. I.
Published: April 2021

Literature data are presented on the development of cryosurgery namely cryosurgery of hepatic diseases in Russia. Expe- rience of surgical diseases' clinics of the Siberian State Medical University in which issues of cryosurgery in focal and diffuse hepatic diseases are developed during last 30 years is described. Creation of original cryosurgical devices, experimental inves-tigation of super-low temperatures influence on the liver is reported, data on clinical using cryosurgical methods of treating tumors, of parasite diseases and of developing cirrhoses of the organ are given. Works of the clinics are original in the number of this problem aspects.
Investigation of the drug «Cycloferon» influence on the morbidity of acute respiratory viral infections and flu and condition of local immunity in children of different age groups
Authors: Kondratieva Ye. I. , Matveeva L. A. , Tyuteva Ye. Yu. , Ryzhakova N. A. , Terentieva A. A. , Logvinenko Yu. I.
Published: April 2021

The aim of the research was the investigation of prophylactic using the drug «Cycloferon». Influence of Cycloferon on acute respiratory viral infection and flu and on their clinical manifestations as well as on local immunity condition was assessed. We examined 124 children aged from 4 to 18 years. It was revealed that duration of acute respiratory viral infections as well as flu decreased and local immunity of the upper respiratory ways increased considerably in children taking Cycloferon. The abovementioned changes were observed both just after the treatment and in the follow-up period.
Reaction of visual nerve to combined influence of ionizing of radiation and bright light
Authors: Potapov A. V.
Published: April 2021

Aimed at revealing the character of modifying influence of ionizing radiation on damages of visual nerve caused by bright light, three series of the experiment were performed. Rats of the first group (n = 10) were subjected to uniform irradiation by LB-40 luminescent lamps (3500 lk, 48 hours). Rats of the second group (n = 20) were subjected to unitary total X-ray radiation in a dozes of 10 and 15 Gr, and rats of the third group ( n = 20) were subjected to combined total influence of x-ray radiation and light of abovementioned parameters with an interval of one hour. The investigation showed that changes in visual nerve after ionizing (10, 15 Gr), light and combined influences are manifested in destruction of organelles, neuro-tubes and neuro-filamentes in axial cylinders and in demyelinizing changes. Quantitative analysis showed that reactions of visual nerve caused by the influence of ionizing radiation are resulted mainly in demyelinization of eye coat and are doze dependent. Combination of investigated factors causes synergic effect which is characterized by increased number of nervous conductors with degenerative changes of axial cylinders and mielinic coats.
Blood system regulation mechanisms in oxygen insufficiency and participation of neural stem cells in the adaptation to hypoxia
Authors: Goldberg Ye. D. , Dygai A. M. , Zyuz’Kov G. N.
Published: April 2021

Large-scale study of regulation and disadaptation mechanisms of blood system in hypoxia of different genesis is performed. Negative influence of encephalopathy and associated with it adrenergic system activation on hemopoiesis is shown which manifests in disturbed erythropoiesis and production of pathologic forms of erythrocytes. Participation of bone marrow mesenchimal stem cells and increased content of neural cells-precursors in central nervous system in conditions of oxygen deficiency are revealed. Failure of the given adaptation mechanisms of “deep reserve” in severe hypoxia which manifests in the development of encephalopathy and disadaptation of hemopoietic tissue is revealed.
Disturbance mechanisms of eosinophils’ and immunocytes’ cooperation in the forming large blood eosinophilias
Authors: Novitsky V. V. , Ryazantseva N. V. , Litvinova L. S. , Kolobovnikova Yu. V. , Grigoryeva Ye. S. , Suvorova Ye. V.
Published: April 2021

Data of modern literature and results of own investigations concerning the role of imbalance of immune-regulatory cytokines’ system in the mechanisms of forming severe eosinophilias of blood in pathologic processes of different genesisare analyzed in the article