bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis, Cytotoxicity and Antiviral Activity Against Vaccinia Virus of
2-(3-Coumarinyl)-1-Hydroxyimidazoles
Authors: Nikitina Polina A. , Zakharova Anastasia M. , Serova Olga A. , Bormotov Nikolay I. , Mazurkov Oleg Y. , Shishkina Larisa N. , Koldaeva Tatiana Y. , Basanova Elizaveta I. , Perevalov Valery P.
Published: November 2022

Background:

In 1980, smallpox became the first viral disease eradicated through vaccination.
After the termination of the Smallpox Eradication Program, the global immunization of the
population also ceased. Now, most people do not have any immunity against infections caused by
orthopoxviruses. Emerging cases of zoonotic orthopox infections transferring to humans inspire the
search for new small organic molecules possessing antiviral activity against orthopoxviruses.

Objective:

Here, we present the synthesis and evaluation of antiviral activity against one of the orthopoxviruses,
i.e., Vaccinia virus, of hybrid structures containing 1-hydroxyimidazole and benzopyranone
moieties.

Methods:

Novel 2-(3-coumarinyl)-1-hydroxyimidazoles were synthesized. Their prototropic tautomerism
was considered using 1H NMR spectroscopy. Antiviral activity of both new 2-(3-coumarinyl)-
1-hydroxyimidazoles and previously described 2-(3-chromenyl)-1-hydroxyimidazoles against Vaccinia
virus was evaluated in Vero cell culture.

Results:

Newly synthesized 2-(3-coumarinyl)-1-hydroxyimidazoles existed in CDCl3 as a mixture of
prototropic tautomers (N-hydroxyimidazole and imidazole N-oxide), transition to DMSO-d6 resulting
in the prevalence of N-oxide tautomer. Evaluation of cytotoxicity and antiviral activity against Vaccinia
virus was performed in Vero cell culture. Compounds possessing high antiviral activity were
present in both series. It was demonstrated that the structure of heterocyclic substituent in position 2
of imidazole impacted the cytotoxicity of substances under consideration. Thus, molecules containing
coumarin moiety exhibited lower toxicity than similarly substituted 2-(3-chromenyl)-1-
hydroxyimidazoles.

Conclusion:

Perspective virus inhibiting compounds possessing antiviral activity against Vaccinia
virus were revealed in the series of 2-(3-coumarinyl)-1-hydroxyimidazoles.
The Effect of Hydroquinidine on Proliferation and Apoptosis of TMZ-sensitive and
-resistant GBM Cells
Authors: Demircan Turan , Yavuz Mervenur
Published: November 2022

Background:

Glioblastoma multiforme (GBM) is a lethal form of central nervous system cancer with a lack of efficient therapy options. Aggressiveness and invasiveness of the GBM result in poor prognosis and low overall survival. Therefore, the necessity to develop new anti-carcinogenic agents in GBM treatment is still a priority for researchers. Ion channels are one of the primary regulators of physiological homeostasis with additional critical roles in many essential biological processes related to cancer, such as invasion and metastasis. A multi-channel blocker, hydroquinidine (HQ), is currently in use to treat short-QT and Brugada arrhythmia syndromes.

Objective:

The objective of the study was to examine the alterations in survival, clonogenicity, migration, tumorigenicity, proliferation, apoptosis, and gene expression profile of temozolomide (TMZ)-sensitive and TMZ-resistant GBM cells upon HQ treatment.

Methods:

The possible anti-neoplastic activity of HQ on GBM cells was investigated by several widely applied cell culture methods. The IC50 values were determined using the MTT assay. Upon HQ treatment, the clonogenicity and migration capacity of cells were evaluated via colony-formation and wound healing assay, respectively. For anti-proliferative and apoptotic effects, EdU and CFSE, and Annexin-V labeling were applied. Tumorigenicity level was depicted by employing soft agar assay. The expression level of multiple genes functioning in the cell cycle and apoptosis-related processes was checked utilizing qPCR.

Results:

A significant anti-carcinogenic effect of HQ on TMZ-sensitive and -resistant GBM cells characterized by the increased apoptosis and decreased proliferation rate was revealed due to the altered gene expression profile related to cell cycle and cell death.

Conclusion:

In this study, the anti-carcinogenic effect of HQ has been demonstrated for the first time. Our data suggest the possible utilization of HQ to suppress the growth of GBM cells. Further studies on GBM-bearing animal models are required to assess its therapeutic potential in GBM treatment.
Potential Polymorphic CYP1A2 and CYP2D6-mediated Pharmacokinetic
Interactions between Risperidone or Olanzapine and Selected Drugs
Intended to Treat COVID-19
Authors: Alvarado Yarasca Angel Tito , Rojas-Macetas Ariana , Medalla-Garro Geraldine , Saravia María , Losno Ricardo , Valderrama-Wong Milton , Pariona Ricardo
Published: November 2022

Risperidone/olanzapine are antipsychotics used in Peru to control symptoms of
psychosis. The objective was to review the available evidence on potential pharmacokinetic
interactions mediated by CYP1A2 and CYP2D6 polymorphic genes between risperidone or
olanzapine and selected drugs for the treatment of COVID-19. A bibliographic search was
conducted in SciELO and PubMed/Medline. The selection criteria included all types of articles in
English and Spanish languages. In this review, the CYP1A2/CYP2D6/CYP3A4 genes that encode
their respective enzymes have been described. The olanzapine/risperidone association increases the
risk of prolonging the QT interval; chloroquine/hydroxychloroquine decreases metabolism and
increases plasma concentration of risperidone; ritonavir decreases metabolism and increases plasma
levels of hydroxychloroquine and lopinavir with the risk of prolonging the QT interval of the cardiac
cycle and with a tendency to progression towards Torsades de Pointes. Ritonavir increases
metabolism and decreases plasma levels of olanzapine. A low incidence of adverse effect was found
between risperidone/azithromycin and olanzapine with azithromycin and hydroxychloroquine.
Regarding the association of genes: CYP1A2*1D increases and CYP1A2*1F decreases the plasma
concentration of olanzapine. Risperidone plasma levels are increased in CYP2D6 intermediate and
poor metabolizers compared with normal metabolizers. Other studies indicate no significant
association between poor metabolizers of CYP1A2 and CYP2D6 with increased pharmacokinetic
parameters. It is concluded that there are potential risks of prolonging the QT interval due to
pharmacokinetic interactions mediated by polymorphic genes CYP1A2 and CYP2D6 between
risperidone or olanzapine and the drugs selected for the treatment of COVID-19.
Real-time Assessment of Interspecies Candida Biofilm Formation
Authors: Abrantes Pedro M.D.S. , Behardien Kauthar , Africa Charlene W.J.
Published: November 2022

Background:

Candida infections are responsible for increased morbidity and mortality in immunocompromised patients, with Candida having the ability to form highly structured biofilms that protect them from the external environment and the action of antifungals. Few studies have reported on real-time interactions between Candida species.

Objective:

This study aimed to investigate the interspecies biofilm changes of oral Candida species using the xCELLigence system and the CV staining technique.

Methods:

This study demonstrated the mixed biofilm interactions of Candida species using an impedance-based biofilm monitoring system and crystal violet staining.

Results:

When using the xCELLigence system, the maximum cell index increased in most mixed biofilms, except for the C. glabrata/C. parapsilosis and C. albicans combinations. Bulk biofilm formation measured by CV staining was the highest in C. albicans and C. tropicalis combinations and the lowest in the C. glabrata/C. parapsilosis combination. Pseudohyphae were observed in C. albicans and C. glabrata in combination with C. tropicalis or C. parapsilosis.

Conclusion:

This study is the first to report on the real-time interactions of Candida species using the xCELLigence system and suggests that the presence of specific species influences the biofilm formation of commonly isolated Candida species.
Quinazolinone: Pharmacophore with Endless Pharmacological Actions
Authors: Dhanawat Meenakshi , Gupta Sumeet , Mujwar Somdutt
Published: November 2022

Due to its extensive applications in the field of pharmaceutical chemistry and its potent biological and pharmacological activities, including analgesic, antioxidant, antimicrobial, anticancer, ant-inflammatory, anti-tubercular, antihyperlipidemic, antihistamine, antiviral, anticonvulsant and antiparkinsonian, the heterocyclic molecule occupies a distinct place in the scientific community. The discovery that many synthetic quinazolinone derivatives exhibit a wide range of biological functions has sparked interest in this area of study.
The purpose of this review is to collate literature work reported by researchers on quinazolinone and its derivatives for their various pharmacological activities.
The Need to Prioritize Model-Updating Processes in Clinical Artificial Intelligence (AI) Models: Protocol for a Scoping Review
Authors: Otokiti Ahmed Umar , Ozoude Makuochukwu Maryann , Williams Karmen S , Sadiq-onilenla Rasheedat A , Ojo Soji Akin , Wasarme Leyla B , Walsh Samantha , Edomwande Maxwell
Published: November 2022

Background

With an increase in the number of artificial intelligence (AI) and machine learning (ML) algorithms available for clinical settings, appropriate model updating and implementation of updates are imperative to ensure applicability, reproducibility, and patient safety.

Objective

The objective of this scoping review was to evaluate and assess the model-updating practices of AI and ML clinical models that are used in direct patient-provider clinical decision-making.

Methods

We used the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist and the PRISMA-P protocol guidance in addition to a modified CHARMS (Checklist for Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies) checklist to conduct this scoping review. A comprehensive medical literature search of databases, including Embase, MEDLINE, PsycINFO, Cochrane, Scopus, and Web of Science, was conducted to identify AI and ML algorithms that would impact clinical decision-making at the level of direct patient care. Our primary end point is the rate at which model updating is recommended by published algorithms; we will also conduct an assessment of study quality and risk of bias in all publications reviewed. In addition, we will evaluate the rate at which published algorithms include ethnic and gender demographic distribution information in their training data as a secondary end point.

Results

Our initial literature search yielded approximately 13,693 articles, with approximately 7810 articles to consider for full reviews among our team of 7 reviewers. We plan to complete the review process and disseminate the results by spring of 2023.

Conclusions

Although AI and ML applications in health care have the potential to improve patient care by reducing errors between measurement and model output, currently there exists more hype than hope because of the lack of proper external validation of these models. We expect to find that the AI and ML model-updating methods are proxies for model applicability and generalizability on implementation. Our findings will add to the field by determining the degree to which published models meet the criteria for clinical validity, real-life implementation, and best practices to optimize model development, and in so doing, reduce the overpromise and underachievement of the contemporary model development process.

International Registered Report Identifier (IRRID)

PRR1-10.2196/37685
Studies on the Rapid and Simple DNA Extraction Method, Antibacterial Activity and Enzyme Activity Involved in Plant Biomass Conversion by Cookeina sulcipes and C. tricholoma (Cup Fungi)
Authors: Tangthirasunun Narumon , Poeaim Supattra
Published: November 2022

Cookeina sulcipes and C. tricholoma are a cup fungi (Ascomycota) collected in Saraburi, Thailand. The fungi have been isolated, cultured and confirmed as respective species. For morphology, both Cookeina sp. are white mycelium and the growth rate on potato dextrose agar (PDA) result present C. sulcipes is faster than C. tricholoma. The molecular characterization from a rapid and simple DNA extraction method that is modified based on thermolysis method, The DNA extraction is finish in thirty minutes and efficiency to continuous with polymerase chain reaction (PCR) amplification to fungi species level identification. The DNA sequence from internal transcribed spacer (ITS) gene regions by universal primer pairs ITS5/ITS4 is effective to confirm Cookeina species level that C. sulcipes has 616 bp and C. tricholoma has 570 bp. Including, DNA sequence of large subunit (LSU) gene regions by universal primer pairs LROR/LR5 is generate that C. sulcipes has 912 bp and C. tricholoma has 906 bp. The cultures are screened for antibacterial activity by agar plug diffusion method and found that both isolates have been no activity against test strains (Bacillus subtilis, Escherichia coli, Kocuria rhizophila (Micrococcus luteus), Pseudomonas aeruginosa, Staphylococcus aureus and S. epidermidis). In a preliminary screening test of enzymes involved in plant biomass breakdown by agar plate method, both Cookeina sp. show cellulolytic and hemicellulolytic enzymatic activity, and manganese peroxidase (MnP) productivity. In contrast, only C. sulcipes had additional laccase activity. Neither isolate generate pectinolytic and lignin peroxidase (LiP) activities. Thus, Cookeina spp. proved the potentiality to break down lignocelluloses.
Efektivitas Dinas Perpustakaan dan Kearsipan Provinsi Jawa Timur Dalam Meningkatkan Gemar Baca Masyarkat
Authors: Ainun Vina Qurroti , Indartuti Endang , Hariyoko Yusuf
Published: November 2022

Penelitian ini bertujuan untuk mengetahui efektivitas dinas perpustakaan dan kearsipan dalam meningkatkan gemar baca masyarakat, berdasarkan Undang-Undang Nomor 43 Tahun 2007 tentang Perpustakaan, perpustakaan adalah fasilitas atau tempat menyediakan sarana bahan baca. Metode penelitian dibuat dengan metode kualitatif, dengan proses observasi di tempat, dibuat secara terstruktur dan akademis data yang diperoleh dari hasil wawancara dengan pihak-pihak terkait, dokumentasi dan menjabarkan. Hasilnya Dinas Perpustakaan dan Kearsipan Provinsi Jawa Timur berhasil menaikkan gemar baca masyarakat jawa timur melebihi yang ditargetkan pada Renstra, hal ini dikarenakan giatnya usaha dari pustakawan untuk terus mengajak masyarakat untuk membaca melalui online maupun offline serta mengajak anak-anak untuk menjadikan membaca adalah sebuah kebiasaan. Meskipun begitu menurut SAKIP, kinerja para pustakawan cenderung menurun karena pandemi yang melanda dan tetap terkategorikan baik. Adapun beberapa factor-faktor yang mempengaruhi belum maksimal dalam meningkatkan gemar baca masyarakat, seperti kurangnya SDM, kurangnya kesadaran masyarakat jawa timur terhadap membaca dan menjadikan membaca adalah sebuah budaya, dan kurangnya pembangunan dan pengembangan jenis perpustakaan. Dengan factor-faktor yang mempengaruhi gemar baca, ada upaya-upaya yang bisa dilakukan oleh Dinas Perpustakaan dan Kearsipan Provinsi Jawa Timur untuk meningkatkan gemar baca masyarakat seperti sosialisasi dan promosi kepada masyarakat tentang pentingnya membaca, memperbanyak jumlah SDM, dan meratakan pembangunan dan pengembangan perpustakaan-perpustakaan di seluruh wilayah jawa timur.
PENGGUNAAN COUNTERWEIGHT DAN SOIL NAILING SEBAGAI ALTERNATIF PERKUATAN LERENG SUNGAI GANDONG MAGETAN JAWA TIMUR PASCA LONGSOR
Authors: Rina Zusianti  , Luthfi Amri Wicaksono  , Paksitya Purnama Putra
Published: November 2022

Longsor terjadi di lereng Sungai Gandong Magetan. Lokasi sungai yang berada di tengah perkotaan mengakibatkan longsoran hampir mencapai rumah warga. Perlu dilakukan upaya peningkatan stabilitas lereng agar aman terhadap longsor. Analisis stabilitas lereng menggunakan metode LEM (Limit Equilibrium Method) dengan progam bantu Geoslope. Hasil analisis stabilitas lereng kondisi eksisting mendapatkan nilai faktor keamanan 0.379. Alternatif perkuatan yang direncanakan ialah pembuatan lereng counterweight. Perencanaan timbunan lereng counterweight sebanyak 4 tingkat dengan tinggi 3 m setiap tingkatnya. Hasil analisis stabilitas lereng counterweight mendapatkan nilai faktor keamanan sebesar 0.507. Area kritis berada pada bagian atas lereng sehingga ditambahkan perkuatan soil nailing. Hasil analisis stabilitas lereng counterweight dengan perkuatan soil nailing dan bronjong didapatkan nilai faktor keamanan sebesar 1.507. Sehingga perencanaan perkuatan lereng tersebut aman terhadap longsor.
Techlex: a corporate practice to initiate inclusive agri-food value chain development in China
Authors: Zhou Yunyi , Hu Song , Chen Kevin Z.
Published: November 2022

A tradeoff lies between inclusiveness and economic efficiency in meeting the Sustainable Development Goals such as poverty reduction, food security, and climate resilience. Vertical coordination between agribusinesses and farmers, in tandem with corporate social responsibility, has been perceived as an approach to surmount such tradeoff from a micro perspective. In a localized context of developing economies, the vertical coordination with farmers is reducible to a path for agribusinesses towards inclusive local value chain development (LVCD) at the grassroots level. However, few models are documented for agribusiness managers to refer to in practice. This study harnesses the Techlex Group and its pig business as a case, zooming in on the vertical coordination of agribusiness and vulnerable smallholders in lagging rural areas of China. Based on an overview of China’s pig industry and Techlex’s value chain, this study highlights three inclusive models and their alternatives for the LVCD. Though proffered in the Chinese context, those models can enrich the LVCD toolkit and be attuned to fit a different scenario.
Influence of Fermentation Conditions on The Antioxidant and Physico-Chemical of Arabica Coffee from Kerinci Region of Indonesia
Authors: Nizori Addion , Jayanti Elkanah , Surhaini Surhaini , Gusriani Ika , Mursyid Mursyid , Purba Daniel Tua
Published: November 2022

Abstract—Coffee quality can depend on several factors such as the species/varieties cultivated, the processing after the harvesting phase, geographical origin, and climatic factors. Fermentation is one of the post harvest technology that influence coffee chemical and sensory properties. This study was to determine the effect of fermentation time into antioxidant and physicochemical of Arabica coffee from Kerinci region Indonesia. Research design used was randomized complete design with 5 combinations of treatments, which are 12, 20, 28, 36, and 44 hours fermentation with 3 replicates. The results shows fermentation time have a significant effects on moisture content, pH, antioxidant activity. The duration of fermentation results in increasing higher moisture content, lower pH value and decreased antioxidants.

Keywords— Anaerobic fermentation, coffee processing, antioxidan
Perbuatan Menguntit (Stalking) dalam Perspektif Kebijakan Hukum Pidana Indonesia
Authors: Br Sinaga Anita , Usman Usman , Wahyudhi Dheny
Published: November 2022

This thesis aims to find out the regulation about stalking in the Criminal Code (Wvs), and to analyze legal policy against the act of stalking for the criminal law reform in Indonesia. The method used is normative juridical, namely the process of discovering the rule of law, legal principles, and legal doctrines. This study uses a statutory approach, conceptual approach, and a case approach. This research was conducted by collecting legal materials obtained from library materials includes primary, secondary and tertiary legal materials. The results of this study are: Stalking is an act that attacks the right to privacy other people and the Criminal Code (Wvs) has not explicitly regulates the act of stalking as a criminal act. Due to the article inside The Criminal Code has not specifically regulated Stalking's act, then reform of the criminal law is needed to reinforce the offenses and the classification regarding the Stalking act. Criminal law reform is important to carried out to realize better legislation in order in the future it can solve the crime of Stalking.
ABSTRAK
Artikel ini bertujuan untuk mengetahui pengaturan mengenai perbuatan menguntit (stalking) dalam KUHP di Indonesia, dan untuk menganalisis kebijakan hukum terhadap perbuatan menguntit (stalking) dalam pembaharuan hukum pidana di Indonesia. Adapun metode yang digunakan adalah yuridis normatif, yaitu suatu proses untuk menemukan aturan hukum, prinsip-prinsip hukum, dan doktrin-doktrin hukum. Penelitian ini menggunakan pendekatan peraturan perundang-undangan, pendekatan konseptual, dan pendekatan kasus. Penelitian ini dilakukan dengan mengumpulkan bahan hukum yang didapat dari bahan-bahan pustaka yang meliputi bahan hukum primer, sekunder dan tersier. Hasil penelitian ini adalah perbuatan menguntit (stalking) merupakan perbuatan yang menyerang hak privasi orang lain dan KUHP belum mengatur secara tegas dan eksplisit mengenai perbuatan stalking sebagai suatu tindak pidana. Dikarenakan pasal di dalam KUHP belum secara khusus mengatur mengenai perbuatan Stalking, maka diperlukan pembaharuan hukum pidana untuk mempertegas delik-delik dan klasifikasi mengenai perbuatan Stalking. Pembaharuan hukum pidana penting dilakukan untuk mewujudkan perundang-undangan yang lebih baik agar kedepannya dapat menanggulangi tindak pidana Stalking.
Peranan Pusat Pelayanan Terpadu Pemberdayaan Perempuan dan Anak (P2TP2A) dalam Memberikan Perlindungan Hukum Terhadap Perempuan dan Anak Korban KDRT
Authors: Fitriani Dona , Haryadi Haryadi , Rakhmawati Dessy
Published: November 2022

The objectives of this study are: to determine implementation of the role of the Integrated Service Center for the Empowerment of Women and Children (P2TP2A) providing legal protection for women and children victims of domestic violence (KDRT). To find obstacles providing legal protection for women and children for being victims. Research Method: The method used is Juridical Empirical. Research Results: 1)Role’s implementation of the P2TP2A in Muaro Jambi providing legal protection for women and children by providing socialization, then implementing the Law of Child Protection and Law of Republic Indonesia of Elimination of Domestic Violence. 2)Obstacles experienced by P2TP2A Muaro Jambi providing legal protection for women and children. Namely, not having a safe house, limited budget, lacking human resources, many people who do not understand the law, victims and their families are not open in providing information, withdrawal of complaints from the police, P2TP2A Muaro Jambi lacks psychologists. Suggestion: The government should cooperate with P2TP2A in Muaro Jambi dealing with KDRT’s case and the community should be give more understanding regarding domestic violence’s law.
 
ABSTRAK
Penelitian ini bertujuan untuk mengetahui pelaksanaan peranan Pusat Pelayanan Terpadu Pemberdayaan Perempuan dan Anak (P2TP2A) Kabupaten Muaro Jambi dan kendalanya dalam memberikan perlindungan hukum terhadap perempuan dan anak korban KDRT. Tipe penelitian ini adalah Yuridis Empiris. Hasil penelitian adalah pelaksanaan peranan P2TP2A Kabupaten Muaro Jambi dengan memberikan sosialisasi, penerapan Undang-Undang Tentang Perlindungan Anak dan Undang-Undang Tentang Penghapusan Kekerasan Dalam Rumah Tangga. Sedangkan kendala yang dialami yaitu tidak mempunyai Rumah Aman, anggaran yang terbatas, SDM  yang kurang, masyarakat yang kurang paham dengan hukum, korban dan keluarga tidak terbuka dalam memberikan keterangan, penarikan pengaduan dari pihak Kepolisian dan kekurangan psikolog. Saran: diharapkan pemerintah dapat bekerjasama dengan baik dengan P2TP2A Kabupaten Muaro Jambi dalam menangani kasus KDRT dan masyarakat diberikan pemahaman hukum mengenai KDRT.
Strategically aligning human resources skills in preparation for the Fourth Industrial Revolution
Authors: Mkhize Lindokuhle Vuyisile Bridget , Parumasur Sanjana Brijball
Published: November 2022

Preparing for the Fourth Industrial Revolution (4IR) is imperative to facilitate the survival of businesses through effective manpower planning. Layoffs, in a country tormented by escalating unemployment, will be futile and will exacerbate the already unsurmountable unemployment problem. The obvious action is to prevent the loss of social capital and for human resource (HR) managers to upskill employees and find the right skills for the job in an effort to align HR skills required with the new opportunities that 4IR will bring to the workplace. The 4IR is at the doorstep of business. Those businesses that do not prepare adequately for it will face dramatic consequences. There is a paucity of research providing guidelines and strategies that businesses can consider and adopt in efforts to plan for the 4IR climate. This study, therefore, assesses the activities that HR managers, especially in businesses in developing countries, can adopt and engage in order to guide the organisation to have the appropriate skills and talent to transition into the 4IR work environment. The study adopts a grounded theory approach to explore what is needed to achieve a sustainable 4IR. It provides HR professionals with insight into the 4IR skills alignment framework, digital skills and competencies needed in the 4IR and recommendations to enable practitioners to effectively prepare for the 4IR (Adams, 2006; South African Board for People Practices [SABPP], 2012). HR managers play a pivotal role in predicting future changes that affect the workforce and in guiding the organisation to transition from a values-driven standpoint.
Photographing Ophelia: Myth and Concept in Eugènia Balcells’s Ophelia (variacions sobre una imatge)
Authors: Ugalde Sharon Keefe
Published: November 2022

This essay examines the groundbreaking work of Catalan art photographer Eugènia Balcells’s 1979 black and white series, Ophelia (variacions sobre una imatge) as an act of feminist re-appropriation of one of the most popular subjects of Victorian painting and early photography. Baleei Is reclaims the canonical literary character by reproducing John Everett Millais’s famous Ophelia (1852) in 37 black-and-white photocopies, then manipulating each of the images in ways that both reveal and resist the patriarchal constructs that informed earlier artists’ view of Shakespeare’s heroine as submissive, passive, ethereal-dead, asleep or in a melancholy trance. After a careful historical contextualization of nineteenth century images of Ophelia in painting and in commercial photography, Keefe Ugalde engages in a close reading of a dozen or more of Balcells’s images, explaining how the artist relied on postmodern conceptual art practices to critique, disparage or subvert the ways in which Ophelia served to anchor patriarchal representations of women, and particularly young desirable women, to traditional models of submissive femininity.
Morphometric and volumetric analysis of the proximity between the incisive canal and maxillary central incisors during anterior retraction: a retrospective cone-beam computed tomography study
Authors: Ongprakobkul Narubhorn , Ishida Yuji , Petdachai Sirima , Ishizaki Aiko , Shimizu Chiyo , Techalertpaisarn Paiboon , Ono Takashi
Published: November 2022

Objectives

To elucidate the relationships and factors affecting the proximity between the incisive canal (IC) and maxillary central incisors and to predict the probable outcomes after anterior tooth retraction using cone beam computed tomography (CBCT).

Materials and Methods

Retrospective CBCT data taken before and after maxillary anterior retraction in 36 patients were used in this study. The incisive canal length (ICL), maxillary central incisor length (TL), angles between the palatal plane and axes of the maxillary alveolar border (θ1), IC (θ2), and maxillary central incisor (θ3), retraction distance (TDE), distance from the maxillary central incisors to the IC (D), cross-sectional area of the IC (CSA), and volume of the IC were evaluated. Comparison of the parameters between contact and noncontact groups were examined. Logistic regression was performed to analyze the probable outcome prediction.

Results

All parameters significantly decreased after anterior retraction, except for the ICL. Eighteen roots in 12 patients contacted the IC. The θ1, θ2, θ3, and D values at all levels were significantly lower, whereas the TDE, midlevel and oral opening CSA, and volume were significantly higher in the contact group compared with the noncontact group. The larger the pretreatment θ1 and θ3 were, the higher was the chance of incisors not contacting the IC.

Conclusions

Maxillary central incisors not contacting the IC after anterior retraction was positively associated with larger degrees of pretreatment maxillary alveolar bone angle and maxillary central incisor angle.
SISTEM MONITORING DAN PENYIRAM TANAMAN OTOMATIS BERBASIS ANDROID DENGAN APLIKASI BLYNK
Authors: Ulinuha Agus , Riza Almas Ghulam
Published: November 2022

Indonesia merupakan negara kepulauan dengan lahan yang cukup luas. Potensi lahan yang luas serta penduduknya yang gemar bercocok tanam membuat Indonesia terkenal dengan hasil pertaniannya. Kesuburan tanah merupakan faktor penting dalam pertumbuhan tanaman yang salah satunya ditentukan oleh kadar air dalam tanah. Dalam melakukan penyiraman tanaman, volume air yang diberikan mempengaruhi pertumbuhan tanaman. Kadar air yang terlalu banyak dapat menyebabkan tanaman membusuk, namun kadar air yang terlalu sedikit dapat menyebabkan tanaman layu atau terhambat pertumbuhannya. Untuk membantu penyiraman tanaman dengan volume air yang tepat, dirancang sebuah sistem penyiram tanaman otomatis yang menyesuaikan tingkat kelembaban tanah. Untuk tujuan tersebut, dikembangkan sistem penyiram tanaman yang memanfaatkan mikrokontroller NodeMcu dan sensor kelembaban untuk mendapatkan data kelembaban tanah yang kemudian ditampilkan dalam LCD. NodeMcu juga dimanfaatkan untuk memantau kelembaban tanah yang ditampilkan dalam smartphone yang terhubung melalui jaringan wifi dengan aplikasi Blynk sebagai user interface. Adapun informasi yang ditampilkan dalam smartphone meliputi persentase kelembaban tanah, kondisi tanah, nilai ADC pembacaan sensor, grafik nilai ADC serta tombol virtual yang dapat digunakan untuk menyalakan pompa secara manual. Berdasarkan hasil pembacaan sensor, pada kondisi kering, persentase tertinggi adalah 68% dalam media pasir kering, persentase terendah atau saat kondisi basah didapatkan nilai 22% dalam media air. Dari hasil test implementasi sistem, didapatkan pompa menyala ketika kondisi tanah kering dengan persentase 39%. Untuk pengujian jarak kendali pompa melalui smartphone, didapatkan jarak maksimal yang dapat dicapai adalah 12 meter.
Perancangan Sistem Informasi Sekolah Berbasis Website Sebagai Sarana Promosi Pada SDN Toso 02
Authors: Subroto Anom Wisnu , Agustina Risa Ayu , Chelsea Fischella Angieta , Anggoro Dimas Aryo
Published: November 2022

Perkembangan teknologi informasi telah dimanfaatkan berbagai bidang, termasuk bidang pendidikan. Salah satu pemanfaatan teknologi informasi pada bidang pendidikan yaitu sebagai sarana untuk promosi kepada masyarakat. Tujuan penelitian ini adalah merancang sistem informasi sekolah berbasis website sebagai sarana promosi pada SDN Toso 02. Sistem informasi ini disusun menggunakan metode pengembangan perangkat lunak prototyping. Sistem informasi dirancang menggunakan bootstrap, javascript, dan Cascading Style Sheets (CSS). Hasil dari penelitian ini adalah dibangunnya website SDN Toso 02 yang digunakan sebagai sarana promosi kepada masyarakat luas. Website ini menampilkan beberapa informasi mengenai SDN Toso 02 diantaranya profil, galeri, prestasi, serta fasilitas sekolah. Berdasarkan hasil pengujian, sistem yang dirancang dapat berjalan sesuai dengan kebutuhan.
KATA KUNCI: sekolah, sistem informasi, website
Research of the structure and mechanical properties of microplasm porous coatings for biomedical purposes
Authors:   Department of Strength of Welded Structures, E. O. Paton Electric Welding Institute of the National Academy of Sciences of Ukraine, Dyman Marianna , Moltasov Andrii ,   Department of Strength of Welded Structures, E. O. Paton Electric Welding Institute of the National Academy of Sciences of Ukraine, Kaliuzhnyi Sergii ,   Department of Protective Coatings, E. O. Paton Electric Welding Institute of the National Academy of Sciences of Ukraine, Kyslytsia Oleksandr ,   Department of Protective Coatings, E. O. Paton Electric Welding Institute of the National Academy of Sciences of Ukraine, Tsymbalista Tania ,   Department of Protective Coatings, E. O. Paton Electric Welding Institute of the National Academy of Sciences of Ukraine
Published: November 2022

The purpose of this work is to justify the feasibility of using the technology of microplasma sputtering from wire materials to obtain porous coatings for biomedical purposes, the modulus of elasticity of which is close to the corresponding characteristic of human cortical bone tissue. Analyzed the influence of the technological parameters of the microplasma sputtering regime on the degree of porosity of the coating. As a result, it was found that a decrease in current strength and consumption of plasma-forming gas, as well as a decrease in the speed of feeding the sprayed wire into the plasma jet lead to an increase in the porosity of the coatings. Even though these parameters are interrelated, for each individual material are limited by certain limit values, in case of nonobservance of which the stable process of melting and dispersion of the sprayed wire in the plasma jet becomes impossible. Established the limit parameters of the microplasma sputtering process for titanium alloy VT1-00 and zirconium alloy KTC-110, which allows obtaining a coating with maximum porosity. Conducted studies of the adhesion strength of the obtained coatings, formed through a low-porous sublayer, with the maximum degree of porosity according to the ASTM C633- 13 (2017) method which proven that the indicators of the adhesion strength of the coatings to the VT6 titanium alloy base at normal separation meet the requirements of the international quality standard ISO 13179- 1:2021.
LOCAL GOVERNMENTS FINANCIAL REPORTING QUALITY IN PAPUA AND WEST PAPUA: DO LOCAL GOVERNMENT CHARACTERISTICS MATTER?
Authors: Firmansyah Amrie , Arfiansyah Zef , Yuniar Muhamad Rizal
Published: November 2022

This study investigates the effect of local government size, local government spending, and the local government dependence level on the financial reporting quality. This study employs a quantitative method. The research data summarizes the financial statements of the regency/city governments in Papua and West Papua from 2016 to 2020. The data is sourced from www.djpk.kemenkeu.go.id and www.bpk.go.id. By using purposive sampling, the sample amounted to 207 observations. The hypothesis testing of this research was conducted employing logistic regression. The test results suggest that the local government size and local government spending are positively associated with financial reporting quality. In contrast, the local government dependence level is negatively associated with financial reporting quality.
Transition of English Language Teaching in Saudi Arabia: A Critical Evaluative Study
Authors: Khawaji Ahmad
Published: November 2022

As the paper revolves around English language spread and teaching in the Kingdom of Saudi Arabia (KSA), it becomes necessary to mention that there are influential socio-political reasons to consider, along with the internal economic factors. Therefore, such factors are crucial for researchers and pedagogues to study and deal with such issues mot only in KSA but across the globe. This paper tends to explore global socio-political factors that exerted an effect on KSA political forces that shaped the transformation process within the English language teaching programs. This paper adopts a critical approach to evaluate the extent literature on ELT status, current practices, programs, and future prospectsin KSA and call for a new evaluative approach that is more critical. Keeping the focus of the study in view, main research questions formulated were related to the status of ELT in KSA, the role of vision-2030 in changing the status of ELT, Saudi English workforce readiness to take up the future challenges of ELT, need of native teachers to teach English in KSA, etc. Main findings were: the status of English has changed in recent year, and it is going to change very fast in coming years to maintain pace with the Saudi vision 2030. In addition, it was found that the need of recruiting native teacher is not imperative anymore as the younger Saudi graduates are going to take up the teaching responsibilities quite independently.
English Majors’ Perceptions of Chinese-English Translation Learning and Translation Competence
Authors: Liu Qian , Abdullah Tina , Sook Kang Myoung
Published: November 2022

Translation is an indispensable language activity and communication method. Translation from Chinese to foreign languages, especially English, is significant to tell Chinese stories well, growing into an urgent issue in China. While cultivating translation talents is crucial, translation competence is a complicated system consisting of various sub competences. To improve English majors’ Chinese-English (C-E) translation competence, it is necessary to first investigate their perceptions of C-E translation learning and competence. Based on the preliminary mastery of English majors’ status quo in C-E translation learning and competence, this research sheds insight into the C-E translation pedagogy. This paper presented: How do English majors perceive C-E translation learning and C-E translation competence? To answer the question, this study adopted a survey research design that was quantitative and applied the instrument of two questionnaires. The multiple-choice questionnaire was to investigate their perceptions of C-E translation learning, and the five-Likert scale questionnaire was to seek their self-perceived C-E translation competence. The study was carried out in 2022 among 125 English majors at Zaozhuang University, China. The results showed that most participants recognized the importance of C-E translation and their primary purpose was to enhance bilingual proficiency, and the texts that they were most interested in translating were practical styles and on diverse topics of China. Furthermore, more than half held the active involvement of teachers and learners and over 85% affirmed the effect of group learning and individual learning. It was found that their mean score of self-perceived C-E translation competence was 2.87.
Time-series comparison of COVID-19 case fatality rates across 21 countries with adjustment for multiple covariates
Authors: Kim Yongmoon , Kim Bryan Inho , Tak Sangwoo
Published: November 2022

Objectives: Although it is widely used as a measure for mortality, the case fatality rate (CFR) of coronavirus disease 2019 (COVID-19) can vary over time and fluctuate for many reasons other than viral characteristics. To compare the CFRs of different countries in equal measure, we estimated comparable CFRs after adjusting for multiple covariates and examined the main factors that contributed to variability in the CFRs among 21 countries.Methods: For statistical analysis, time-series cross-sectional data were collected from Our World in Data, CoVariants.org, and GISAID. Biweekly CFRs of COVID-19 were estimated by pooled generalized linear squares regression models for the panel data. Covariates included the predominant virus variant, reproduction rate, vaccination, national economic status, hospital beds, diabetes prevalence, and population share of individuals older than age 65. In total, 21 countries were eligible for analysis.Results: Adjustment for covariates reduced variation in the CFRs of COVID-19 across countries and over time. Regression results showed that the dominant spread of the Omicron variant, reproduction rate, and vaccination were associated with lower country-level CFRs, whereas age, the extreme poverty rate, and diabetes prevalence were associated with higher country-level CFRs.Conclusion: A direct comparison of crude CFRs among countries may be fallacious, especially in a cross-sectional analysis. Our study presents an adjusted comparison of CFRs over time for a more proper comparison. In addition, our findings suggest that comparing CFRs among different countries without considering their context, such as the epidemic phase, medical capacity, surveillance strategy, and socio-demographic traits, should be avoided.
Antimicrobial impacts of zinc oxide nanoparticles on Shiga toxin-producing Escherichia coli (serotype O26)
Authors: Sherif Rasha M. , Talat Dalia , Alaidaroos Bothaina A. , Farsi Reem M. , Hassoubah Shahira A. , Jaber Fatima A. , Azer Treza M. , El-Masry Reham M. , Abd El-Hack Mohamed E. , Ibrahim Madiha S. , Elbestawy Ahmed
Published: November 2022

The antibacterial activity of zinc oxide nanoparticles (ZnO NPs) has received significant attention worldwide due to the emergence of multidrug-resistant microorganisms. Shiga toxin-producing Escherichia coli is a major foodborne pathogen that causes gastroenteritis that may be complicated by hemorrhagic colitis or hemolytic uremic syndrome. Therefore, this study aimed to evaluate the antimicrobial effect of ZnO NPs against E. coli O26 and its Shiga toxin type 2 (Stx2). Multidrug resistance phenotype was observed in E. coli O26, with co-resistance to several unrelated families of antimicrobial agents. Different concentrations of ZnO NPs nanoparticles (20 nm) were tested against different cell densities of E. coli O26 (108, 106 and 105 CFU/ml). The minimum inhibitory concentration (MIC) value was 1 mg/ml. Minimum bactericidal concentration (MBC) was 1.5 mg/ml, 2.5 mg/ml and 3 mg/ml, respectively, depending on ZnO NPs concentrations and bacterial cell density. Results showed a significant (P≤0.05) decrease in Stx2 level in a response to ZnO NPs treatment. As detected by quantitative real-time PCR, ZnO NPs down-regulated the expression of the Stx2 gene (P≤0.05). Moreover, various concentrations of ZnO NPs considerably reduced the total protein content in E. coli O26. There was a significant reduction in protein expression with increased ZnO NPs concentration compared to the non-treated control. Scanning electron micrographs (SEM) of the treated bacteria showed severe disruptive effects on E. coli O26 with increasing ZnO NPs concentration. The results revealed a strong correlation between the antibacterial effect and ZnO NPs concentrations. ZnO NPs exert their antibacterial activities through various mechanisms and could be used as a potent antibacterial agent against E. coli O26.
Literary Form and Ethical Content
Authors: Lamarque Peter
Published: November 2022

The paper offers a qualified endorsement of Terry Eagleton’s striking claim that “a work’s moral outlook … may be secreted as much in its form as its content”. A number of points are raised in defence of the claim: an argument for the inseparability, under certain conditions, of form and content in a literary work; an idea of moral content, not as derived moral principle, but as inward-facing interpretation grounded in an ethical vocabulary; the possibility of internal and external perspectives on fictional characters; and an emphasis on emotions expressed in, rather than caused by, narrative. Three literary examples are explored, to show how vocabulary, syntax, implicature, and tone, contribute to the emergence of moral salience. A consequence drawn is that the ethical stance readers take to a scene or incident is partially shaped by the narrative modes of its presentation. The overall perspective of the paper is that of aesthetic autonomism: the view that the aesthetic value of a work of literature is distinct from, and not reducible to, any instrumental moral values (positive or negative) attributed to the work.
Assessing the Ethos Theory of Music
Authors: Young James O.
Published: November 2022

The view that music can have a positive or negative effect on a person’s character has been defended throughout the history of philosophy. This paper traces some of the history of the ethos theory and identifies a version of the theory that could be true. This version of the theory can be traced to Plato and Aristotle and was given a clear statement by Herbert Spencer in the nineteenth century. The paper then examines some of the empirical literature on how music can affect dispositions to behave and moral judgement. None of this evidence provides much support for the ethos theory. The paper then proposes a programme of research that has the potential to confirm the ethos theory.
Effect of Organic Fertilization on the Physiological Status of Tomatoes under Abiotic Stress
Authors: Kostadinov Kostadin , Chipilski Radoslav , Filipov Stoyan , Shopova Nadezhda
Published: November 2022

During the vegetation period of the years 2020 and 2021 in the experimental field at Agricultural University - Plovdiv it was conducted a physiological study of tomato cultivar (Rugby) with determined growth under the treatment with chemical and organic fertilizers. The aims of the study were to determine the changes in physiological behaviour and productivity of field tomatoes depending on the fertilization and dates of planting. The physiological assessment included the measuring of some parameters of chlorophyll fluorescence and chlorophyll content index. Chlorophyll fluorescence has proved to have the potential to detect abiotic stress effects on photosynthetic efficiency. This technique was used to assess growth intensity in tomato plants (Solanum lycopersicum), grown in different types of fertilizer treatment and planted in three additional dates – 30.04, 07.05 and 14.05 in conditions of ambient heat stress. Results have shown the slight effect of the applied organic fertilizer upon fluorescence parameters but significantly improved chlorophyll content index compared to no treatment variant. Additionally, it was measured higher chlorophyll content index for the second and third planting dates. The highest average yield was calculated for the NPK variant, as the statistically significant differences of the yield between control and fertilization variants were calculated in 2021. It possessed the highest average yield for second planting compared to the third date of planting.