bluuebunny/crossref_metadata_2025 huggingface dataset:
The Need for Status, Organizational Citizenship Behavior, and Overall Evaluation: Focusing on the Moderating Effects of Political Skill and Task Visibility
Authors: Park Jisung , Chae Heesun
Published: January 2024

Drawing on the costly signaling theory (CST), this study examined the need for status as a hidden motive to increase organizational citizenship behavior (OCB) and result in the focal employee’s overall evaluation. Moreover, as the activating cues, this study considered political skill as an individual characteristic and task visibility as a situational factor in the relationship between the need for status, OCB, and overall evaluation. To test these predictions, we obtained and analyzed 299 questionnaire responses from pairs of subordinates and supervisors in various South Korean industries. The analytical results supported our hypotheses that the need for status increased OCB, resulting in high performance appraisal. Moreover, task visibility positively moderated the relationship between the need for status and overall evaluation, which was mediated by OCB. However, political skill exhibited a negative moderation effect on this mediation process. These findings have important theoretical and practical implications, and they also highlight directions for future research.
Association of Spousal Social Support in Child-Rearing and Marital Satisfaction with Subjective Well-Being among Fathers and Mothers
Authors: Iwasa Hajime , Yoshida Yuko , Ishii Kayoko
Published: January 2024

This study explored the association of spousal support and marital satisfaction with the subjective well-being of fathers and mothers using a mediation analysis. Data were gathered from 360 fathers and 338 mothers (aged 25–50 years). Subjective well-being was measured as an outcome using the Japanese version of the World Health Organization-Five Well-Being Index. Marital satisfaction was measured as a mediating variable using the Japanese version of the Marital Relationship Satisfaction Scale. Spousal social support (including instrumental, emotional, and appraisal support) was measured as an independent variable using four-point scales. Control variables were the father’s and mother’s ages, number of children, age of the youngest child, children going to nursery school or kindergarten, use of childcare services, self-evaluated low economic status, and weekday working hours. Among fathers, instrumental and emotional support had significant direct and indirect effects, with the latter mediated by the impact of marital satisfaction on subjective well-being; appraisal support had only significant indirect effects. Among mothers, instrumental support had significant direct and indirect effects; emotional and appraisal support had only significant indirect effects. Our findings indicate that social support from spouses has protective direct and indirect effects on subjective well-being among parents and suggest the need for mutual support between spouses to facilitate effective co-parenting.
An Approach to Mixture Design and Cost Analysis for Cement Pastes Composed of Class C Fly Ashes for Better Sustainable Construction
Authors: Egemen Mehmedali , Ali Farhad , Aydin Ertug
Published: January 2024

The increase in population and need for shelter demand a huge amount of concrete production. These construction activities cause environmental problems and global warming continues to threaten the world. In this study, the properties of cement paste composites containing high proportions of fly ash are intended for use as sustainable ecological products in various civil engineering applications to minimize the worse effects of building construction. The physical, mechanical, and durability properties of pure cement paste composed of fly ash were investigated. New insight is presented in this study to show how to use fly ash in the paste for a wide range of workability with better optimization of physical and mechanical characterization with cost performance and to design the composites to achieve specific engineering properties. The proposed approach can help researchers model the pastes for various ranges of workability and strength. This modeling approach can potentially be used to construct mixture design criteria for such composites. The unconfined compressive strength (UCS) showed very good results with the porosity of the paste, UCS = a × (1 − porosity)b; thus, this equation can be used for the strength determination of pastes at various workability ranges.
Sarcopenia in Breast Cancer Patients: A Systematic Review and Meta-Analysis
Authors: Roberto Michela , Barchiesi Giacomo , Resuli Blerina , Verrico Monica , Speranza Iolanda , Cristofani Leonardo , Pediconi Federica , Tomao Federica , Botticelli Andrea , Santini Daniele
Published: January 2024

(1) Background: We estimated the prevalence and clinical outcomes of sarcopenia among breast cancer patients. (2) Methods: A systematic literature search was carried out for the period between July 2023 and October 2023. Studies with breast cancer patients evaluated for sarcopenia in relation to overall survival (OS), progression-free survival (PFS), relapse of disease (DFS), pathological complete response (pCR), or toxicity to chemotherapy were included. (3) Results: Out of 359 screened studies, 16 were eligible for meta-analysis, including 6130 patients, of whom 5284 with non-MBC. Sarcopenia was evaluated with the computed tomography (CT) scan skeletal muscle index and, in two studies, with the dual-energy x-ray absorptiometry (DEXA) appendicular lean mass index. Using different classifications and cut-off points, overall, there were 2007 sarcopenic patients (33%), of whom 1901 (95%) presented with non-MBC. Sarcopenia was associated with a 33% and 29% higher risk of mortality and progression/relapse of disease, respectively. Sarcopenic patients were more likely to develop grade 3–4 toxicity (OR 3.58, 95% CI 2.11–6.06, p < 0.0001). In the neoadjuvant setting, a higher rate of pCR was observed among sarcopenic patients (49%) (OR 2.74, 95% CI 0.92–8.22). (4) Conclusions: Our meta-analysis confirms the correlation between sarcopenia and negative outcomes, especially in terms of higher toxicity.
Role of Creative Therapies in Gynecological Oncology: Results of a Multigenerational Survey in Patients and Caregivers
Authors: Jantke Bettina , Sehouli Jalid , Rose Matthias , Boer Jolijn , Jantke Andreas , Dimitrova Desislava , Woopen Hannah , Pirmorady-Sehouli Adak
Published: January 2024

Introduction: Although creative therapies like painting, dancing, and writing are often used and encouraged to treat various diseases, including cancer, there are few systematic scientific studies on innovative therapies in medical care. Methods: An anonymous survey was developed for female patients, their relatives, and female medical staff on the impact of creative therapies on optimizing clinical therapy management in exclusively female trials. Results: Of 718 respondents, 358 were female patients, 69 were medical personnel, and 291 were in the control group. Overall, 91.2% of respondents had sought access to creative therapies, indicating strong self-motivated engagement in activities to improve health and well-being. This study also uncovered a significant preference for creative writing among patients. Furthermore, the data suggest that integrating innovative therapies into biopsychosocial anamnesis could offer valuable insights into patients’ mobility, mood, and social behaviors. Despite a general hesitation to discuss leisure activities with medical professionals, many patients wanted to incorporate creative activities into their treatment plans. Moreover, group settings for innovative therapy were preferred, highlighting the need for more structured support in medical environments to facilitate these therapeutic interactions. Conclusions: This study suggests creative therapies can be valuable in medical care.
T Cell Features in Glioblastoma May Guide Therapeutic Strategies to Overcome Microenvironment Immunosuppression
Authors: Losurdo Agnese , Di Muzio Antonio , Cianciotti Beatrice Claudia , Dipasquale Angelo , Persico Pasquale , Barigazzi Chiara , Bono Beatrice , Feno Simona , Pessina Federico , Santoro Armando , Simonelli Matteo
Published: January 2024

Glioblastoma (GBM) is the most aggressive and lethal primary brain tumor, bearing a survival estimate below 10% at five years, despite standard chemoradiation treatment. At recurrence, systemic treatment options are limited and the standard of care is not well defined, with inclusion in clinical trials being highly encouraged. So far, the use of immunotherapeutic strategies in GBM has not proved to significantly improve patients’ prognosis in the treatment of newly diagnosed GBM, nor in the recurrent setting. Probably this has to do with the unique immune environment of the central nervous system, which harbors several immunosuppressive/pro-tumorigenic factors, both soluble (e.g., TGF-β, IL-10, STAT3, prostaglandin E2, and VEGF) and cellular (e.g., Tregs, M2 phenotype TAMs, and MDSC). Here we review the immune composition of the GBMs microenvironment, specifically focusing on the phenotype and function of the T cell compartment. Moreover, we give hints on the therapeutic strategies, such as immune checkpoint blockade, vaccinations, and adoptive cell therapy, that, interacting with tumor-infiltrating lymphocytes, might both target in different ways the tumor microenvironment and potentiate the activity of standard therapies. The path to be followed in advancing clinical research on immunotherapy for GBM treatment relies on a twofold strategy: testing combinatorial treatments, aiming to restore active immune anti-tumor responses, tackling immunosuppression, and additionally, designing more phase 0 and window opportunity trials with solid translational analyses to gain deeper insight into the on-treatment shaping of the GBM microenvironment.
A Validated Methodological Approach to Prove the Safety of Clinical Electromagnetic Induction Systems in Magnetic Hyperthermia
Authors: Rouni Maria Anastasia , Shalev Boaz , Tsanidis George , Markakis Ioannis , Kraus Sarah , Rukenstein Pazit , Suchi Doron , Shalev Ofer , Samaras Theodoros
Published: January 2024

The present study focuses on the development of a methodology for evaluating the safety of MNH systems, through the numerical prediction of the induced temperature rise in superficial skin layers due to eddy currents heating under an alternating magnetic field (AMF). The methodology is supported and validated through experimental measurements of the AMF’s distribution, as well as temperature data from the torsos of six patients who participated in a clinical trial study. The simulations involved a computational model of the actual coil, a computational model of the cooling system used for the cooling of the patients during treatment, and a detailed human anatomical model from the Virtual Population family. The numerical predictions exhibit strong agreement with the experimental measurements, and the deviations are below the estimated combined uncertainties, confirming the accuracy of computational modeling. This study highlights the crucial role of simulations for translational medicine and paves the way for personalized treatment planning.
Pre-Operative Malnutrition in Patients with Ovarian Cancer: What Are the Clinical Implications? Results of a Prospective Study
Authors: Nasser Sara , Bilir Esra , Derin Xezal , Richter Rolf , Grabowski Jacek P. , Ali Paulina , Kulbe Hagen , Chekerov Radoslav , Braicu Elena , Sehouli Jalid
Published: January 2024

Background: Malnutrition was associated with worse survival outcomes, impaired quality of life, and deteriorated performance status across various cancer types. We aimed to identify risk factors for malnutrition in patients with epithelial ovarian cancer (EOC) and impact on survival. Methods: In our prospective observational monocentric study, we included the patients with primary and recurrent EOC, tubal or peritoneal cancer conducted. We assessed serum laboratory parameters, body mass index, nutritional risk index, nutritional risk screening score (NRS-2002), and bio-electrical impedance analysis. Results: We recruited a total of 152 patients. Patients > 65 years-old, with ascites of >500 mL, or with platinum-resistant EOC showed statistically significant increased risk of malnutrition when evaluated using NRS-2002 (p-values= 0.014, 0.001, and 0.007, respectively). NRS-2002 < 3 was an independent predictive factor for complete tumor resectability (p = 0.009). The patients with NRS-2002 ≥ 3 had a median overall survival (OS) of seven months (95% CI = 0–24 months), as compared to the patients with NRS-2002 < 3, where median OS was forty-six months (p = 0.001). A phase angle (PhAα) ≤ 4.5 was the strongest predictor of OS. Conclusions: In our study, we found malnutrition to be an independent predictor of incomplete cytoreduction and independent prognostic factor for poor OS. Preoperative nutritional assessment is an effective tool in the identification of high-risk EOC groups characterized by poor clinical outcome.
Decoding the Tumour Microenvironment: Molecular Players, Pathways, and Therapeutic Targets in Cancer Treatment
Authors: Malavasi Eleonora , Adamo Manuel , Zamprogno Elisa , Vella Viviana , Giamas Georgios , Gagliano Teresa
Published: January 2024

The tumour microenvironment (TME) is a complex and constantly evolving collection of cells and extracellular components. Cancer cells and the surrounding environment influence each other through different types of processes. Characteristics of the TME include abnormal vasculature, altered extracellular matrix, cancer-associated fibroblast and macrophages, immune cells, and secreted factors. Within these components, several molecules and pathways are altered and take part in the support of the tumour. Epigenetic regulation, kinases, phosphatases, metabolic regulators, and hormones are some of the players that influence and contribute to shaping the tumour and the TME. All these characteristics contribute significantly to cancer progression, metastasis, and immune escape, and may be the target for new approaches for cancer treatment.
Ion-Exchange Synthesis of Surrounded CoNi@Al2O3 Catalyst for Levulinic Acid Hydrogenation to γ-Valerolactone under Mild Conditions
Authors: Ding Hongzhi , Yang Chenyu , Jiang Congyan , Luo Wei , Wang Qiuyue , Guo Xuefeng
Published: January 2024

The use of eco-friendly biomass as a resource is an efficient way to address the problems of fossil fuel depletion and climate change. In biomass conversion, versatile γ-valerolactone (GVL) is generally obtained from levulinic acid (LA) hydrogenation via a multimetallic catalyst system. Despite conversion efficiency being enhanced in mild conditions due to metal interactions, maintaining high catalyst stability is still a challenge. In this study, we synthesized a surrounded Co0.52Ni0.48@Al2O3-IE catalyst that exhibited excellent alloying and synergistic interaction between the metal constituents. Under relatively mild reaction conditions, the GVL yield over the catalyst exceeded 99% in LA hydrogenation. The catalyst showed no deactivation in a test of five cycles, displaying superiority in stability, possibly due to reasons of the physical isolation of the shell and the alumina retention on the Co-Ni alloys surface caused by the reversibility of exchange equilibrium. The present work demonstrated that a surrounded structured catalyst fabricated by ion exchange (IE) with active metals physically enclosed can lead to high catalytic activity and superior stability.
Aldolase: A Desirable Biocatalytic Candidate for Biotechnological Applications
Authors: Mathipa-Mdakane Moloko G. , Steenkamp Lucia
Published: January 2024

The utilization of chemical reactions is crucial in various industrial processes, including pharmaceutical synthesis and the production of fine chemicals. However, traditional chemical catalysts often lack selectivity, require harsh reaction conditions, and lead to the generation of hazardous waste. In response, biocatalysis has emerged as a promising approach within green chemistry, employing enzymes as catalysts. Among these enzymes, aldolases have gained attention for their efficiency and selectivity in catalyzing C-C bond formation, making them versatile biocatalysts for diverse biotechnological applications. Despite their potential, challenges exist in aldolase-based biocatalysis, such as limited availability of natural aldolases with desired catalytic properties. This review explores strategies to address these challenges, including immobilization techniques, recombinant expression, and protein engineering approaches. By providing valuable insights into the suitability of aldolases as biocatalysts, this review lays the groundwork for future research and the exploration of innovative strategies to fully harness the potential of aldolases in biotechnology. This comprehensive review aims to attract readers by providing a comprehensive overview of aldolase-based biocatalysis, addressing challenges, and proposing avenues for future research and development.
Tuning Almond Lipase Features by Using Different Immobilization Supports
Authors: Cherni Oumaima , Carballares Diego , Siar El Hocine , Abellanas-Perez Pedro , de Andrades Diandra , Rocha-Martin Javier , Bahri Sellema , Fernandez-Lafuente Roberto
Published: January 2024

The lipase from Prunus dulcis almonds has been immobilized for the first time. For this purpose, two different supports, an octadecyl methacrylate particulate support, and aminated agarose (monoaminoethyl-N-aminoethyl) have been utilized. Both immobilized biocatalysts show improved enzyme stability, but great changes in enzyme specificity were detected. The enzyme immobilized via ion exchange maintained its activity intact versus p-nitrophenyl butyrate, while the enzyme immobilized on the hydrophobic support fully lost its activity versus this substrate, which was confirmed to be due to substrate adsorption on the support. However, this biocatalyst was much more active versus triacetin (more than 10-fold), R- or S- methyl mandelate at pH 7. At pH 9, a strong effect of using phosphate or bicarbonate as reaction buffers was detected. Using bicarbonate, the interfacially immobilized enzyme presented no activity versus R-isomer, but it was very active versus the S-isomer and triacetin. Using a phosphate buffer during the reaction, all compounds were recognized as substrates. The enzyme immobilized via ion exchange was significantly more active using phosphate; in fact, using bicarbonate, the enzyme was inactive versus both methyl mandelate isomers. This paper shows for the first time a great interaction between the effects of the immobilization protocol and buffer used during reaction on the enantiospecificity of lipases.
Post-Anesthesia Cognitive Dysfunction in Mice Is Associated with an Age-Related Increase in Neuronal Intracellular [Ca2+]—Neuroprotective Effect of Reducing Intracellular [Ca2+]: In Vivo and In Vitro Studies
Authors: Uryash Arkady , Mijares Alfredo , Lopez Carlos E. , Adams Jose A. , Allen Paul D. , Lopez Jose R.
Published: January 2024

Background: Postoperative cognitive dysfunction (POCD) is a common disorder after general anesthesia in elderly patients, the precise mechanisms of which remain unclear. Methods: We investigated the effect of isoflurane with or without dantrolene pretreatment on intracellular calcium concentration ([Ca2+]i), reactive oxygen species (ROS) production, cellular lactate dehydrogenase (LDH) leak, calpain activity, and cognitive function using the Morris water maze test of young (3 months), middle-aged (12–13 months), and aged (24–25 months) C57BL6/J mice. Results: Aged cortical and hippocampal neurons showed chronically elevated [Ca2+]i compared to young neurons. Furthermore, aged hippocampal neurons exhibited higher ROS production, increased LDH leak, and elevated calpain activity. Exposure to isoflurane exacerbated these markers in aged neurons, contributing to increased cognitive deficits in aged mice. Dantrolene pretreatment reduced [Ca2+]i for all age groups and prevented or significantly mitigated the effects of isoflurane on [Ca2+]i, ROS production, LDH leak, and calpain activity in aged neurons. Dantrolene also normalized or improved age-associated cognitive deficits and mitigated the cognitive deficits caused by isoflurane. Conclusions: These findings suggest that isoflurane-induced cytotoxicity and cognitive decline in aging are linked to disruptions in neuronal intracellular processes, highlighting the reduction of [Ca2+]i as a potential therapeutic intervention.
Giant Cell Arteritis: Advances in Understanding Pathogenesis and Implications for Clinical Practice
Authors: Paroli Marino , Caccavale Rosalba , Accapezzato Daniele
Published: January 2024

Giant cell arteritis (GCA) is a noninfectious granulomatous vasculitis of unknown etiology affecting individuals older than 50 years. Two forms of GCA have been identified: a cranial form involving the medium-caliber temporal artery causing temporal arteritis (TA) and an extracranial form involving the large vessels, mainly the thoracic aorta and its branches. GCA generally affects individuals with a genetic predisposition, but several epigenetic (micro)environmental factors are often critical for the onset of this vasculitis. A key role in the pathogenesis of GCA is played by cells of both the innate and adaptive immune systems, which contribute to the formation of granulomas that may include giant cells, a hallmark of the disease, and arterial tertiary follicular organs. Cells of the vessel wall cells, including vascular smooth muscle cells (VSMCs) and endothelial cells, actively contribute to vascular remodeling responsible for vascular stenosis and ischemic complications. This review will discuss new insights into the molecular and cellular pathogenetic mechanisms of GCA, as well as the implications of these findings for the development of new diagnostic biomarkers and targeted drugs that could hopefully replace glucocorticoids (GCs), still the backbone of therapy for this vasculitis.
Effects of Temperature Adaptation on the Metabolism and Physiological Properties of Sturgeon Fish Larvae Cell Line
Authors: Lutze Philipp , Brenmoehl Julia , Tesenvitz Stephanie , Ohde Daniela , Wanka Heike , Meyer Zianka , Grunow Bianka
Published: January 2024

This study investigated how Atlantic sturgeon cells respond to elevated temperatures, shedding light on the potential impacts of climate change on fish. Atlantic sturgeon (Acipenser oxyrinchus), an IUCN (International Union for Conservation of Nature) Red List species and evolutionarily related to paleonisiform species, may have considerable physiological adaptability, suggesting that this species may be able to cope with changing climatic conditions and higher temperatures. To test this hypothesis, the AOXlar7y cell line was examined at 20 °C (control) and at elevated temperatures of 25 °C and 28 °C. Parameters including proliferation, vitality, morphology, and gene expressions related to proliferation, stemness, and stress were evaluated. Additionally, to achieve a comprehensive understanding of cellular changes, mitochondrial and metabolic activities were assessed using Seahorse XF96. AOXlar7y cells adapted to 28 °C exhibited enhanced mitochondrial adaptability, plasticity, heightened cell proliferation, and increased hsp70 expression. Increased baseline respiration indicated elevated ATP demand, which is potentially linked to higher cell proliferation and heat stress defense. Cells at 28 °C also displayed elevated reserve respiration capacity, suggesting adaptation to energy demands. At 25 °C, AOXlar7y cells showed no changes in basal respiration or mitochondrial capacity, suggesting unchanged ATP demand compared to cells cultivated at 20 °C. Proliferation and glycolytic response to energy requirements were diminished, implying a connection between glycolysis inhibition and proliferation suppression. These research results indicate sturgeon cells are capable of withstanding and adapting to an 8 °C temperature increase. This cellular analysis lays a foundation for future studies aimed at a deeper understanding of fish cell physiological adaptations, which will contribute to a better knowledge of environmental threats facing Atlantic sturgeon and fish populations amid climate change.
Evidence for Involvement of ADP-Ribosylation Factor 6 in Intracellular Trafficking and Release of Murine Leukemia Virus Gag
Authors: Kang Hyokyun , Kang Taekwon , Jackson Lauryn , Murphy Amaiya , Nitta Takayuki
Published: January 2024

Murine leukemia viruses (MuLVs) are simple retroviruses that cause several diseases in mice. Retroviruses encode three basic genes: gag, pol, and env. Gag is translated as a polyprotein and moves to assembly sites where viral particles are shaped by cleavage of poly-Gag. Viral release depends on the intracellular trafficking of viral proteins, which is determined by both viral and cellular factors. ADP-ribosylation factor 6 (Arf6) is a small GTPase that regulates vesicular trafficking and recycling of different types of cargo in cells. Arf6 also activates phospholipase D (PLD) and phosphatidylinositol-4-phosphate 5-kinase (PIP5K) and produces phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2). We investigated how Arf6 affected MuLV release with a constitutively active form of Arf6, Arf6Q67L. Expression of Arf6Q67L impaired Gag release by accumulating Gag at PI(4,5)P2-enriched compartments in the cytoplasm. Treatment of the inhibitors for PLD and PIP5K impaired or recovered MuLV Gag release in the cells expressing GFP (control) and Arf6Q67L, implying that regulation of PI(4,5)P2 through PLD and PIP5K affected MuLV release. Interference with the phosphoinositide 3-kinases, mammalian target of rapamycin (mTOR) pathway, and vacuolar-type ATPase activities showed further impairment of Gag release from the cells expressing Arf6Q67L. In contrast, mTOR inhibition increased Gag release in the control cells. The proteasome inhibitors reduced viral release in the cells regardless of Arf6Q67L expression. These data outline the differences in MuLV release under the controlled and overactivated Arf6 conditions and provide new insight into pathways for MuLV release.
Microstructural and Mechanical Properties Analysis of Phosphate Layers Deposited on Steel Rebars for Civil Constructions
Authors: Lazar Petru , Cimpoesu Nicanor , Istrate Bogdan , Cazac Alin Marian , Burduhos-Nergis Diana-Petronela , Benchea Marcelin , Berbecaru Andrei-Constantin , Badarau Gheorghe , Vasilescu Gabriel Dragos , Popa Mihai , Bejinariu Costica
Published: January 2024

This paper carries out a study on the microstructural characteristics and mechanical properties of phosphate layers deposited on steel reinforcements for civil constructions. Analyses were performed on 4 sets of samples: 1 control sample (unphosphated) and 2–4 samples that were phosphated with three different solutions. The structural and chemical analysis, as well as the examination of the mechanical properties (surface roughness, microindentation, and scratch resistance) of the phosphate layers deposited on steel rebars for civil constructions, was carried out. The following conclusions were drawn from the experimental results: the coatings show flashes of crystals deposited on the metal surface; chemical homogenization of the phosphated layers is observed; the profiles present a higher roughness after deposition of the phosphated layers; the indentation Young modulus and hardness values recommend the phosphating procedure to improve the CS surface quality; the COF is three times larger for phosphated samples compared with the initial metallic one; and scratch traces are uninterrupted, except for one zone of sample that was phosphated with solution II, wherein the phosphated layer does not present lateral scratches or exfoliations.
Influence of Tooling on the Properties of the Surface Layer in HEA Alloy Sinters Produced by the SPS Method
Authors: Kopeć-Surzyn Anna , Madej Marcin
Published: January 2024

This paper reports the findings of a study on the Spark Plasma Sintering of High-Entropy Alloys (HEAs) using atomized alloy powder. The sintering process was conducted within a graphite matrix at a predetermined optimum temperature of 1050 °C. The resulting material exhibited a density close to the theoretical value. Hardness tests and microstructural observations revealed the impact of the graphite tool used during the sintering process, particularly in the near-surface layer. Chemical and phase composition analyses indicated the formation of chromium carbides in the near-surface layer, leading to the depletion of FCC phase grains in chromium and alterations in the shape and size of these grains.
Research on Arc Erosion Resistance of High-Entropy Alloy-Modified Aluminum Alloy Armature Based on Molecular Dynamics Simulation
Authors: Teng Yuanxin , Zhang Li , Wang Guan , Wu Meiying , Fan Chenlu , Liu Shushuai
Published: January 2024

In an electromagnetic launch system, the surface of the aluminum alloy armature is subjected to high-temperature ablation, leading to the generation of significant metal vapor and the initiation of high-energy arcs. This damages the armature structure and can result in a launch failure. Enhancing the ablation resistance of the armature surface is crucial for improving launch efficiency. In this study, a model for the surface modification of an aluminum alloy armature was constructed. The impact of the CoCrNiFeAlx surface-modified material on the resistance to ablation and structural changes of the armature during arc ablation was elucidated through molecular dynamics simulation. Results show that adding a CoCrNiFeAlx fused cladding layer can effectively enhance the material’s high-temperature resistance. The CoCrNiFeAlx fused cladding significantly reduces the depth of arc intrusion. The CoCrNiFeAlx aluminum alloy model exhibits a narrower strain range on the bombarded surface and a more flattened bombardment crater shape. CoCrNiFeAlx fused cladding helps to reduce damage from substrate bombardment. Comparing simulation results indicates that CoCrNiFeAl0.25 performs best in high-temperature resistance and impact strength, making it the most preferred choice. This study elucidates the law of high-entropy alloy arc ablation resistance and its micromechanism in armature surface modification. It provides a theoretical basis and technical support for preparing high-entropy alloy–aluminum alloy-modified armatures with superior ablation resistance performance.
Maxwell’s True Current
Authors: Eisenberg Robert S.
Published: January 2024

Maxwell defined a ‘true’ or ‘total’ current in a way not widely used today. He said that “… true electric current … is not the same thing as the current of conduction but that the time-variation of the electric displacement must be taken into account in estimating the total movement of electricity”. We show that the true or total current is a universal property of electrodynamics independent of the properties of matter. We use mathematics without the approximation of a dielectric constant. The resulting Maxwell current law is a generalization of the Kirchhoff law of current used in circuit analysis, that also includes the displacement current. The generalization is not a long-time low-frequency approximation in contrast to the traditional presentation of Kirchhoff’s law.
Security and Privacy of Technologies in Health Information Systems: A Systematic Literature Review
Authors: Shojaei Parisasadat , Vlahu-Gjorgievska Elena , Chow Yang-Wai
Published: January 2024

Health information systems (HISs) have immense value for healthcare institutions, as they provide secure storage, efficient retrieval, insightful analysis, seamless exchange, and collaborative sharing of patient health information. HISs are implemented to meet patient needs, as well as to ensure the security and privacy of medical data, including confidentiality, integrity, and availability, which are necessary to achieve high-quality healthcare services. This systematic literature review identifies various technologies and methods currently employed to enhance the security and privacy of medical data within HISs. Various technologies have been utilized to enhance the security and privacy of healthcare information, such as the IoT, blockchain, mobile health applications, cloud computing, and combined technologies. This study also identifies three key security aspects, namely, secure access control, data sharing, and data storage, and discusses the challenges faced in each aspect that must be enhanced to ensure the security and privacy of patient information in HISs.
Numerical Microstructure Prediction for Lattice Structures Manufactured by Electron Beam Powder Bed Fusion
Authors: Koepf Johannes A. , Pistor Julian , Markl Matthias , Körner Carolin
Published: January 2024

The latest advances in additive manufacturing have given rise to an increasing interest in additively built lattice structures due to their superior properties compared to foams and honeycombs. The foundation of these superior properties is a tailored microstructure, which is difficult to achieve in additive manufacturing because of the variety of process parameters influencing the quality of the final part. This work presents the numerical prediction of the resulting grain structure of a lattice structure additively built by electron beam powder bed fusion. A thermal finite-difference model is coupled to a sophisticated cellular automaton-based crystal growth model, including nucleation. Numerically predicted grain structures, considering different nucleation conditions, are compared with experimentally derived EBSD measurements. The comparison reveals that nucleation is important, especially in fine lattice structures. The developed software, utilizing the nucleation model, is finally able to predict the as-built grain structure in lattice structures.
The Hydrothermal Method of Preparing Boron–Saccharide Precursors for the Synthesis of Boron Carbide and Its Influence on the Morphology and Phase Composition of the Obtained Products
Authors: Kozień Dawid , Pasiut Katarzyna , Banaś Wojciech , Zagórny Mateusz , Partyka Janusz
Published: January 2024

Owing to its properties, boron carbide has been applied in scientific and industrial fields. For this reason, B4C powders should be characterized by high purity and homogeneity in grain size and shape. In this study, boron carbide was prepared using precursors obtained using a hydrothermal method, and the grain morphology of the product was investigated. Boric acid and the saccharides glucose, fructose, inulin, and sorbitol were used as the precursors. Two precursor dehydration methods, freeze-drying and recrystallization, were compared. The precursors were subjected to DLS grain size and FT-IR spectrophotometric studies, and SEM observations of the precursors and products were performed, confirming that boron carbide powders could be successfully synthesized.
Crystal and Electronic Structure of Ternary Bismuthides BaTM1.8Bi2 (TM = Au, Ag) with a New Variation of the BaAu2Sb2 Structure Type
Authors: Shilov Andrey I. , Rakhmanov Evgeny O. , Lyssenko Konstantin A. , Kuznetsov Alexey N. , Morozov Igor V. , Shevelkov Andrei V.
Published: January 2024

Recently discovered bismuthides with the BaAu2Sb2 structure type demonstrate interesting properties and electronic structures. Here, we report successful crystal growth, crystal structure, band structure calculations, and DOS for BaAg1.8Bi2 and BaAu1.8Bi2. Grown crystals were characterized by a combination of single crystal X-ray diffraction and EDX spectroscopy. Both compounds crystallized in a new variation of BaAu2Sb2 structure type and demonstrated metallic properties according to our DFT calculations.
Neural and Onconeural Autoantibodies and Blood–Brain Barrier Disruption Markers in Patients Undergoing Radiotherapy for High-Grade Primary Brain Tumour
Authors: Hojan Katarzyna , Adamska Krystyna , Lewandowska Agnieszka , Procyk Danuta , Leporowska Ewa , Osztynowicz Krystyna , Michalak Slawomir
Published: January 2024

Radiotherapy (RT) plays a key role in brain tumours but can negatively impact functional outcomes and quality of life. The aim of this study was to analyse anti-neural and onconeural autoantibodies and markers of blood–brain barrier (BBB) disruption in patients with primary brain cancer undergoing RT. Materials and methods. A prospective study was conducted on 45 patients with a brain tumour scheduled for intensity-modulated radiotherapy. Assessments were performed at baseline, post-RT, and at three months. We measured serum levels of BBB disruption biomarkers and anti-neural, onconeural, and organ-specific antibodies. Results. Antibodies against nucleosome antigens and neuronal surface antigens were detected in 85% and 3% of cases, respectively; anti-neural and onconeural antibodies were observed in 47% and 5.8%. In 44% patients, ≥2 antibody types were detected. No significant changes in BBB biomarkers were observed. Conclusion. The findings of this study show that a humoral immune response is common in patients undergoing RT for brain cancer. This response appears to be non-organ specific but rather directed against nucleosome antigens, but onconeural antibodies were uncommon, suggesting a low risk of a neurological paraneoplastic syndrome. Our data suggested that radiotherapy may not affect BBB integrity, but larger studies are needed to better characterise the pathophysiological effects of RT.
Endometriosis and the Role of Pro-Inflammatory and Anti-Inflammatory Cytokines in Pathophysiology: A Narrative Review of the Literature
Authors: Oală Ioan Emilian , Mitranovici Melinda-Ildiko , Chiorean Diana Maria , Irimia Traian , Crișan Andrada Ioana , Melinte Ioana Marta , Cotruș Teodora , Tudorache Vlad , Moraru Liviu , Moraru Raluca , Caravia Laura , Morariu Mihai , Pușcașiu Lucian
Published: January 2024

Endometriosis is a chronic inflammatory disease, which explains the pain that such patients report. Currently, we are faced with ineffective, non-invasive diagnostic methods and treatments that come with multiple side effects and high recurrence rates for both the disease and pain. These are the reasons why we are exploring the possibility of the involvement of pro-inflammatory and anti-inflammatory molecules in the process of the appearance of endometriosis. Cytokines play an important role in the progression of endometriosis, influencing cell proliferation and differentiation. Pro-inflammatory molecules are found in intrafollicular fluid. They have an impact on the number of mature and optimal-quality oocytes. Endometriosis affects fertility, and the involvement of endometriosis in embryo transfer during in vitro fertilization (IVF) is being investigated in several studies. Furthermore, the reciprocal influence between anti-inflammatory and pro-inflammatory cytokines and their role in the pathogenesis of endometriosis has been assessed. Today, we can affirm that pro-inflammatory and anti-inflammatory cytokines play roles in survival, growth, differentiation, invasion, angiogenesis, and immune escape, which provides a perspective for approaching future clinical implications and can be used as biomarkers or therapy.
How to Study the Location and Size of Rectal Tumors That Are Candidates for Local Surgery: Rigid Rectoscopy, Magnetic Resonance, Endorectal Ultrasound or Colonoscopy? An Interobservational Study
Authors: Serracant Anna , Consola Beatriz , Ballesteros Eva , Sola Marta , Novell Francesc , Montes Noemi , Serra-Aracil Xavier
Published: January 2024

1. Background. Preoperative staging of rectal lesions for transanal endoscopic surgery (TES) comprises digital rectal examination, intraoperative rigid rectoscopy (IRR), endorectal ultrasound (EUS), colonoscopy and rectal magnetic resonance imaging (rMRI). The gold standard for topographic features is IRR. Are the results of the other tests sufficiently reliable to eliminate the need for IRR? rMRI is a key test in advanced rectal cancer and is not operator-dependent. Description of anatomical landmarks is variable. Can we rely on the information regarding topographic features provided by all radiologists? 2. Materials and Methods. This is a concordance interobservational study involving four diagnostic tests of anatomical characteristics of rectal lesions (colonoscopy, EUS, rectal MRI and IRR), performed by four expert radiologists, regarding topographic rectal features with rMRI. 3. Results. Fifty-five rectal tumors were operated on by using TES. The distance of the tumor from the anal verge, location by quadrants, size by quadrants and size of tumor were assessed (IRR as gold standard). For most of the tumors, the correlation between IRR and colonoscopy or EUS was very good (ICC > 0.75); the correlation between rMRI and IRR in respect of the size by quadrants (ICC = 0.092) and location by quadrants (ICC = 0.292) was weak. Topographic landmarks studied by the expert radiologists had an excellent correlation, except for distance from the peritoneal reflection to the anal verge (ICC = 0.606). 4. Conclusions. Anatomical description of rectal lesions by IRR, EUS, colonoscopy and rMRI is reliable. Topographic data obtained by EUS and colonoscopy can serve as a reference to avoid IRR. Determination of these topographic data by rMRI is less reliable. As performed by the expert radiologists, the anatomical study by rMRI is accurate and reproducible.
Global Prevalence of Zika and Chikungunya Coinfection: A Systematic Review and Meta-Analysis
Authors: Ahmed Saleh , Sultana Shabiha , Kundu Shoumik , Alam Sayeda Sadia , Hossan Tareq , Islam Md Asiful
Published: January 2024

Zika virus (ZIKV) and chikungunya virus (CHIKV) are arthropod-borne viruses with significant pathogenicity, posing a substantial health and economic burden on a global scale. Moreover, ZIKV-CHIKV coinfection imposes additional therapeutic challenges as there is no specific treatment for ZIKV or CHIKV infection. While a growing number of studies have documented the ZIKV-CHIKV coinfection, there is currently a lack of conclusive reports on this coinfection. Therefore, we performed a systematic review and meta-analysis to determine the true statistics of ZIKV-CHIKV coinfection in the global human population. Relevant studies were searched for in PubMed, Scopus, and Google Scholar without limitation in terms of language or publication date. A total of 33 studies containing 41,460 participants were included in this meta-analysis. The study protocol was registered with PROSPERO under the registration number CRD42020176409. The pooled prevalence and confidence intervals of ZIKV-CHIKV coinfection were computed using a random-effects model. The study estimated a combined global prevalence rate of 1.0% [95% CI: 0.7–1.2] for the occurrence of ZIKV-CHIKV coinfection. The region of North America (Mexico, Haiti, and Nicaragua) and the country of Haiti demonstrated maximum prevalence rates of 2.8% [95% CI: 1.5–4.1] and 3.5% [95% CI: 0.2–6.8], respectively. Moreover, the prevalence of coinfection was found to be higher in the paediatric group (2.1% [95% CI: 0.0–4.2]) in comparison with the adult group (0.7% [95% CI: 0.2–1.1]). These findings suggest that the occurrence of ZIKV-CHIKV coinfection varies geographically and by age group. The results of this meta-analysis will guide future investigations seeking to understand the underlying reasons for these variations and the causes of coinfection and to develop targeted prevention and control strategies.
Composition of the Influence Group in the q-Voter Model and Its Impact on the Dynamics of Opinions
Authors: Weron Tomasz , Nyczka Piotr , Szwabiński Janusz
Published: January 2024

Despite ample research devoted to the non-linear q-voter model and its extensions, little or no attention has been paid to the relationship between the composition of the influence group and the resulting dynamics of opinions. In this paper, we investigate two variants of the q-voter model with independence. Following the original q-voter model, in the first one, among the q members of the influence group, each given agent can be selected more than once. In the other variant, the repetitions of agents are explicitly forbidden. The models are analyzed by means of Monte Carlo simulations and via analytical approximations. The impact of repetitions on the dynamics of the model for different parameter ranges is discussed.
A Mechanistic Model of Perceptual Binding Predicts That Binding Mechanism Is Robust against Noise
Authors: Kraikivski Pavel
Published: January 2024

The concept of the brain’s own time and space is central to many models and theories that aim to explain how the brain generates consciousness. For example, the temporo-spatial theory of consciousness postulates that the brain implements its own inner time and space for conscious processing of the outside world. Furthermore, our perception and cognition of time and space can be different from actual time and space. This study presents a mechanistic model of mutually connected processes that encode phenomenal representations of space and time. The model is used to elaborate the binding mechanism between two sets of processes representing internal space and time, respectively. Further, a stochastic version of the model is developed to investigate the interplay between binding strength and noise. Spectral entropy is used to characterize noise effects on the systems of interacting processes when the binding strength between them is varied. The stochastic modeling results reveal that the spectral entropy values for strongly bound systems are similar to those for weakly bound or even decoupled systems. Thus, the analysis performed in this study allows us to conclude that the binding mechanism is noise-resilient.
University–Museum Partnerships for K-12 Engineering Learning: Understanding the Utility of a Community Co-Created Informal Education Program in a Time of Social Disruption
Authors: Rodegher Sandra Lina , McGowen Lindsey C. , Hughes Micaha Dean , Schaible Sarah E. , Muniz Ayse J. , Hokanson Sarah Chobot
Published: January 2024

This study explores the impact of COVID-19 on informal learning institutions, primarily science museums, through the lens of an activity kit co-created by CELL-MET—a cross-university, engineering research center—and museum partners. While formal learning organizations, like K-12 schools, play a critical role in the education process through standardized teaching, informal learning organizations also make important contributions to the engineering education ecosystem, such as by fostering engineering identity development, especially for learners and their families. This is particularly valuable for young learners from underrepresented and under-resourced communities. In this study, two questions are addressed: (1) How were museums impacted by COVID-19 and the resulting disruptions to their operations, and how did they respond? (2) To what extent were museums able to implement and adapt EEK! to reach under-served youth in the face of social disruption? When the world was experiencing social disruption from the spread of COVID-19, the authors realized they had an opportunity to test the utility and adaptability of their model of engineering activity co-creation. Approximately six months into the launch of both EEK! and the global pandemic, a 29-item survey was distributed to EEK! recipient institutions. Of the museum respondents, 97% reported experiencing full closures and 73% reported layoffs and furloughs. Despite these challenges, 78% implemented EEK!, with 70% of the institutions creating new virtual programming, and 38% adapting EEK! for remote facilitation, including real-time virtual events, self-guided activities, and at-home activity kits. Museums were equally impacted by COVID-19 policies and closures, but have not received the public attention and support that K-12 schools have received. Nonetheless, they have responded with ingenuity in using and adapting EEK!. Given their K-12 partnerships, flexibility, and ability to engage learners, museums are undervalued collaborators for universities trying to impact the K-12 engineering education ecosystem.