bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance da CO-oximetria de pulso para identificação do tabagismo na Atenção Básica
Authors: Silva Júnior José Laerte Rodrigues , Rodrigues Marina Do Carmo , Brito Ana Carolina Poloniato , Prudente Fernando Conforti , Merhi Iassiminy Santos , De Oliveira Gabriela Ferreira Leandro , Zamboni Mirella Mezzomo , Lôbo Daniel Silva , Almeida Winston Andrade , Rocha Luiza Ferreira , Nascimento Guilherme Peixoto
Published: September 2018

Resumo

 

Objetivo: Avaliar o desempenho de um CO-oxímetro para determinação do status do tabagismo em relação a um medidor de monóxido de carbono exalado em indivíduos atendidos na atenção básica.

Métodos: Estudo transversal realizado em pacientes ambulatoriais atendidos nas unidades básicas de saúde de Anápolis-GO, submetidos à avaliação clínica, dosagem do monóxido de carbono exalado e medida do monóxido de carbono por CO-oximetria de pulso.

Resultados: Foram incluídos 449 indivíduos, 106 tabagistas (23,6%), 89 ex-tabagistas (19,8%), 203 nunca fumantes (45,2%) e 51 fumantes passivos (11,4%). A CO-oximetria com ponto de corte de ≥4% mostrou uma especificidade de 77,3% (IC95% 72,5%-81,6%), uma sensibilidade de 52,8% (IC95% 42,9%-62,6%), valores preditivos positivo e negativo de 45,3% (IC95% 38,9%-51,9%), 82,1% (IC95% 78,8%-85%), respectivamente e a área sob a curva ROC de 0,73 (IC95% 0,67-0,78). A dosagem do monóxido de carbono exalado com ponto de corte de ≥5ppm mostrou uma especificidade de 96,2% (IC95% 93,6%-98%), sensibilidade de 79,2% (IC95% 70,3%-86,5%), valor preditivo positivo e negativo de 88,2% (IC95% 81,3%-92,8%), 92,9% (IC95% 89,9%-95%), respectivamente e a área sob a curva ROC de 0,91 (IC95% 0,87-0,95). COHb(%)≥4 demostrou OR:4,3; (IC 95% 2,7-7,1); p<0,0001.

Conclusão: A CO-oximetria apresentou capacidade de identificação do tabagismo inferior à da dosagem do monóxido de carbono exalado, entretanto, quando COHb(%)≥4 há alta probabilidade de tabagismo.
Amamentar e doar leite: percepções das mulheres doadoras de um Banco de Leite Humano
Authors: Rosa e Silva Mateus Guilhardi , Barbosa Karen Cristine Almeida , Borges Lorrayne Aparecida Silveira , Barros Guilherme Ferreira , Cardoso Lucas Gundim , Silveira Marluce Martins Machado da
Published: September 2018

O aleitamento materno é de suma importância para reduzir a morbimortalidade infantil, principalmente nos dois primeiros anos de vida. Além disso, traz impactos positivos para as lactantes tanto fisiologicamente como socioeconômico. Um propagador do aleitamento materno é o Banco de Leite Humano, cuja principal função é promover a amamentação. O objetivo deste estudo é descrever e analisar os fatores que facilitam a doação do leite materno e a amamentação, assim como as dificuldades encontradas na perspectiva das mulheres doadoras. Trata-se de uma pesquisa qualitativa, do tipo descritivo-exploratória, sendo o método de análise hermenêutico-dialética objetivado por Minayo, em que as integrantes são mulheres doadoras do Banco de Leite Humano no período de um mês. A análise das falas permitiu verificar que o principal motivador da prática de amamentar foi o conhecimento dos benefícios da amamentação, enquanto que a de doar leite foram “excesso de leite”, a identificação com mães cujos filhos necessitam do leite doado e ajudar ao próximo. Foram analisadas as dificuldades na amamentação, descritas como a pega incorreta e a percepção de “leite fraco e pouco leite”. Verificou-se a importância do apoio familiar e da equipe de saúde, além do conhecimento do Banco de Leite Humano. Percebe-se que muitas nutrizes sabem da importância da amamentação, contudo, estas mulheres doadoras vivenciam as mesmas dificuldades relatadas em estudos sobre motivos para o desmame, sendo que o apoio e as orientações recebidos no Banco de Leite Humano foram fundamentais para a amamentação e para efetuar a doação de leite materno.
AVALIAÇÃO DAS INTERNAÇÕES POR J09 A J018 NO BRASIL: 2008 A 2015, UMA SÉRIE HISTÓRICA
Authors: Ternes Yves Mauro , Oliveira Júnior Jair Rodrigues de , D'Ávila Vanessa Guimarães de Freitas Cruvelo , D'Ávila Juliana Guimarães de Freitas Cruvelo , Reis Ângela Adamski da Silva , Santos Rodrigo Da Silva
Published: September 2018

Objetivos: avaliar o efeito das intervençõesem saúde (vacina pneumocócica e contra a gripe) nas doenças respiratórias (CID10 J09 a J18). Métodos: realizada pesquisa no Sistema de Informação Nacional das internações e tratamento por Pneumonia e Influenza (gripe), estratificando por faixa etária, entre os anos de 2008 a 2015. Resultados: Nos períodos entre 2008-2010 e 2011-2015, em < 1 e entre 1 e 4 anos, houve uma redução de 20,9% (p = 0,023) e 25,8% (p = 0,009), respectivamente; já acima de 60 anos, houve um aumento de 18% nas hospitalizações (p = 0,023). Entre os períodos pré-vacinal e pós-vacinal, houve uma redução média no tratamento anual de 15,4% (p = 0,027). Conclusões: Diminuição significativa na média das internações e tratamento por J09 a J18 na população menor de cinco anos, fortalecendo a importância destas ações na população infantil. Em indivíduos acima de 60 anos ocorreu o oposto.
Estado da Arte da Residência Multiprofissional em Saúde no Brasil
Authors: Silva Lais Santos , Natal Sônia , Dolny Luise Ludke
Published: September 2018

Objetivo:  Identificar as limitações e facilitadores das Residências Multiprofissionais no Brasil. Fonte de dados: Para operacionalizar o estudo utilizou-se a revisão integrativa nas bases de dados Scientific Eletronic Library Online (SCIELO), Biblioteca Virtual em Saúde (BVS) e Latin American and Caribbean Health Science Literature (LILACS), no período de março  e abril de 2017, a partir dos descritores “Avaliação and residência and multiprofissional”, “Residência and saúde and educação and permanente” e “Residência and multiprofissional”. Sintese de dados: Os achados corroboram para fatores limitantes do programas, tais quais a dificuldade de parcerias entre instituições de ensino e rede de serviços de saúde, a reduzida interação dos atores participantes, a formação primária e especifica dos profissionais. Como elementos potencializadores, citam-se a oportunidade de aquisição de conhecimentos, a formação de profissionais qualificados e ampliação da relação entre teoria-prática nos espaços de aprendizagem. Conclusão: Os artigos selecionados demonstraram os desafios da implantação da residência e sua consolidação a partir de dois paradoxos: o programa representando um importante instrumento de formação de profissionais para o SUS, mas, por outro lado, considerado uma forma de precarização do trabalho.
INDICADORES DE LESÃO E INFLAMAÇÃO MUSCULAR EM ATLETAS -REVISÃO INTEGRATIVA DA LITERATURA
Authors: Rodrigues Teixeira Silva Daameche Hellen , Zampieri Ipolito Michelle , Chieregato Matheus João Paulo
Published: September 2018

Objetivo: buscar na literatura disponível, indícios da liberação de biomarcadores de lesão e inflamação muscular desencadeada pelo exercício físico. Fontes de dados:  Foi realizado levantamento bibliográfico nas bases de dados MEDLINE e LILACS, utilizando os termos: indicators, injuries, inflammation, muscle e athletes. Síntese dos dados: os estudos evidenciaram que há aumento da atividade sérica dos indicadores de lesão e inflamação muscular após realização de exercícios de alta intensidade. Conclusões: Os resultados do estudo corroboram tanto para a implementação de estratégias de treinamentos que visem a melhora do desempenho do atleta, quanto à prevenção de sobrecargas para reduzir o risco de lesões esportivas.
ENCEFALITE POR RICKETTSIA SEM EXANTEMA: A PROPÓSITO DE UM CASO CLÍNICO
Authors: Araújo Talita Fernandes , Ferreira de Assis Luís Pedro , De Lima Paulo Ricardo
Published: September 2018

Objetivo: Relatar caso raro de encefalite por Rickettsia sem exantema. Relato do Caso: Paciente sexo masculino de 44 anos, trabalhador rural, apresentou quadro de febre diária, mialgia e astenia progredindo com amaurose de olho esquerdo, ataxia, flutuação mental, paraparesia de membros inferiores e estrabismo divergente à esquerda. Concerniu-se em tratamento empírico com ceftriaxone e dixiclina para Brucelose, Rickettsia e Lyme. Exame laboratorial positivou para Rickettsia rickettsii. Discussão: A Febre Maculosa é uma doença infecciosa febril aguda, causada pela Rickettsia rickettsii. É adquirida pela picada do carrapato infectado, do gênero Amblyomma. Apresenta um curso clínico variável. O início dos sintomas costuma ser abrupto e inespecíficos. Manifestações neurológicas estão presentes em cerca de 40% dos casos. A Reação de imunofluorescência indireta é o padrão-ouro para o diagnóstico. Os fármacos de melhor eficácia para o tratamento são:  doxiciclina e o cloranfenicol. No Brasil, as taxas de mortalidade giram em torno de 20 a 30%. Considerações finais: A suspeição clínica e início precoce de antibioticoterapia dirigida são fundamentais para prevenir manifestações mais severas e permitir o sucesso terapêutico.
MODELIZACIÓN DEL CRECIMIENTO DE Pinus teocote Schltdl. et Cham. EN EL NORESTE DE MÉXICO
Authors: Aguirre Calderón Oscar Alberto
Published: September 2018

Modelar el crecimiento forestal facilita la estimación de la productividad de estos ecosistemas y el aprovechamiento de una especie en función de la calidad de sitio y del tratamiento silvícola. Con ello se obtienen datos prácticos sobre el crecimiento característico promedio y es factible hacer una estimación rápida y poco costosa del volumen y el desarrollo de los rodales. En este trabajo se elaboraron curvas de índice de sitio y tablas de producción para rodales densos de Pinus teocote en el noreste de México. Los datos proceden de la medición de 280 árboles dominantes y del inventario de 66 sitios temporales de muestreo. Se construyó un diagrama de cinco curvas de índice de sitio con el método de la curva guía aplicado a la función de Richards, con una edad de referencia de 50 años. La metodología empleada para la construcción de las tablas es la de Magin modificada con base en intervalos de altura. Las relaciones entre los parámetros más importantes de los rodales se determinaron mediante ecuaciones de regresión. Los resultados indican que el método es adecuado para generar de forma sencilla herramientas simples para la gestión de esos rodales. El incremento medio anual de la especie varía entre 2.1 y 9.5 m3 ha-1.
CARACTERIZACIÓN DEL SUELO EN COLONIAS DE Cynomys mexicanus Merriam, 1892 EN EL NOROESTE DE MÉXICO
Authors: Pando Moreno Marisela , Reyna Laura , Scott Laura , Jurado Enrique
Published: September 2018

El perrito de las praderas mexicano (Cynomys mexicanus) es endémico del noreste de México y uno de los mamíferos en riesgo de extinción. A pesar de numerosos estudios sobre la especie, se carece de datos ecológicos, en particular en lo referente a las relaciones que establecen con su hábitat. Recientemente se ha destacado que los pastizales halofíticos de esa región del país están pasando por un proceso de degradación y muestran una baja productividad, como se evidencia por los cambios en la estructura y fisonomía del paisaje. Sin embargo, aunque existe una relación entre la fisonomía de la vegetación y el sustrato subyacente, no hay estudios cabales de las propiedades edáficas de sus colonias. Se planteó la hipótesis de que el perrito de las praderas mexicano ocupa diversos hábitats que son identificados a partir de diferentes características del suelo. En este estudio se analizaron las propiedades físicas y químicas del suelo de 36 colonias de ellos localizadas en la región del Altiplano. Esta información pudiera hacer posible la primera definición de las áreas potencialmente apropiadas para la reintroducción de especies como una estrategia de conservación. Se llevó a cabo un análisis de componentes principales con los datos de suelo. Los resultados indican que los suelos estuvieron divididos en dos grandes grupos que proveyeron de hábitat a la especie: i) suelos con un alto contenido de yeso o nulos carbonatos de calcio, y ii) suelos con un alto contenido de carbonato de calcio y con carencia de yeso.
RETORNO POTENCIAL DE NUTRIMENTOS POR COMPONENTES SECUNDARIOS DE LA HOJARASCA EN COMUNIDADES VEGETALES DE NUEVO LEÓN
Authors: Cantú Silva Israel , Sánchez Castillo Laura Rosa Margarita , González Rodríguez Humberto , Kubota Tetsuya , Gómez Meza Marco Vinicio , Domínguez Gómez Tilo Gustavo
Published: September 2018

La caída de hojarasca es un mecanismo muy importante en el ciclo de nutrientes de un ecosistema, por lo cual el objetivo del presente estudio fue determinar el retorno potencial de Ca, K, Mg y P y de micronutrimentos (Cu, Fe, Mn y Zn) a través de las estructuras reproductivas, ramas, corteza e insectos en cuatro comunidades vegetales del noreste de México. La hojarasca se recolectó en tres sitios del Matorral Espinoso Tamaulipeco (Crucitas, Campus y Cascajoso), y uno de bosque de pino-encino (Bosque Escuela), con intervalos de 15 días entre 2006 y 2007. En cada lugar se estableció una parcela (50 m x 50 m) con 10 trampas (1 m2). El calcio (138 kg ha-1 año-1) y fierro (372 g ha-1 año-1) son los elementos que más reciclan los componentes secundarios. El orden en la deposición de macronutrimentos se presentó de la siguiente manera Ca > Mg > K > P, mientras que para micronutrientes fue Fe > Mn > Zn > Cu. El aporte total de estos últimos a los componentes secundarios (Cu+Fe+Mn+Zn) para el Bosque Escuela, Crucitas, Campus y Cascajoso fue de 362.9, 588.5, 234.9 y 218.3 g ha-1 año-1, respectivamente. El correspondiente a micronutrimentos para todos los componentes secundarios representó de 93 a 99% del total de la deposición anual, en los que estos fueron la fuente principal de retorno potencial en los cuatro sitios investigados, mientras que las hojas no constituyen un elemento de aporte importante en el retorno de Cu, Fe, Mn y Zn.
The Moderating Effect of Dividend Policy on Free Cash Flow and Profitability Towards Firm ValueThe Moderating Effect of Dividend Policy on Free Cash Flow and Profitability Towards Firm Value
Authors: Oktaryani G.A Sri , Sofiyah Siti , Mannan Abdul
Published: September 2018

This study is aimed to determine the moderating effect of Dividend Policy on Free Cash Flow and Profitability towards Firm Value. This study use Moderate Regression Analysis (MRA) as tool to analyze the moderating effect of Dividend Policy on the sample tested. Sample are chosen by using purposive sampling method from all manufacture firms that listed on Indonesian Stock Exchange throughout 2010-2015 which offered cash dividend to their shareholders. By using panel data, the findings show that Free Cash Flow and Profitability themselves have significant effect on Firm Value. But conversely, each Free Cash Flow and Profitability does not have significant effect on Firm Value after being moderated by Dividend Policy. It is because the direct effect of Free Cash Flow and Profitability toward Firm value is bigger than the indirect effect. The results indicate that Dividend Policy is just predictor moderation in this case.Keywords:Dividend Policy, Free Cash Flow, Profitability, Firm Value, Manufacture, MRA
Better food choices among users of the Digital Food Guide: a report from Brazil
Authors: Caivano Simone , Domene Semíramis Martins Álvares
Published: September 2018

O acesso fácil à informação possibilita a oportunidade de promover escolhas alimentares saudáveis. Este estudo apresenta o Guia Alimentar Digital (GAD), aplicativo para smartphones, e avalia sua capacidade de promover escolhas alimentares saudáveis. Usuários registram sua ingestão alimentar e recebem dados dos grupos alimentares e Índice de Qualidade da Dieta, pontuação associada ao GAD. Este estudo analisou a ingestão alimentar e peso corporal relatados de 442 usuários de ambos os sexos, entre 19 e 50 anos. Após usar o aplicativo, aproximadamente um terço dos participantes melhoraram seu padrão alimentar e 60% perderam peso (p < 0,01). A percentagem de indivíduos que consumiram dieta de qualidade ruim diminuiu 8,5%, aqueles que obtiveram qualidade intermediária aumentaram 6,8% e os de alta qualidade aumentaram 1,6% (p = 0,01). Tecnologias da informação podem ser recursos adicionais, apoiando a educação nutricional e ajudando as pessoas a comerem conscientemente com resultados positivos para a saúde.
Produção de vídeos educativos sobre saúde a partir da interlocução entre estudantes e pesquisadores
Authors: Bento Sílvio Fernando Bento , Modena Celina Maria , Cabral Stephanie Dos Santos
Published: September 2018

A escola como um espaço de saber – social, dialógico e cultural – é de fundamental importância no processo de popularização dos conhecimentos científicos. Com base em um projeto que se encontra em desenvolvimento, em uma parceria entre a Fiocruz Minas e três escolas da rede pública estadual no município de Belo Horizonte, este artigo relata a interlocução entre escola e pesquisa/ciência. Como estratégia de pesquisa buscou-se envolver ativamente os educandos na construção de questões relacionadas a temas de saúde. Nesse processo de articulação entre escola e instituição de pesquisa, dúvidas e questionamentos distintos levantados em cada uma das escolas foram apresentados aos pesquisadores da Fiocruz, que dialogaram com os discentes. Toda a pesquisa foi registrada na forma de vídeos, visando à construção de um material midiático educativo, que será distribuído na rede pública de ensino do estado de Minas Gerais.
Do silêncio à implicação
Authors: Lisboa Marcia
Published: September 2018

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RANCANG BANGUN SISTEM PENJERNIHAN AIR OTOMATIS BERDASARKAN TURBIDITYMETER BERBASIS MIKROKONTROLLER
Authors: Bachri Affan
Published: September 2018

The turbidity  sensor  works  by reading the  water particles  turbidity level captured by  the Light Dependent Resistor  (LDR)  that  has  been  emitted  by  the  laser  light.  Therefore,  the  LDR  resistance  score  changes  and  it makes  the  Nephelometric  Turbidity  Units  (NTU)  score  also  changes.  The  solenoid  valve  is  controlled  by  the suitability of the readings of the desired turbidity meter sensor by the operator.
EVALUASI KUALITAS MARKETPLACE ABC.COM BERDASARKAN KERANGKA KERJA KEPUASAN PENGGUNA, WEBQUAL 4.0 DAN IMPORTANCE PERFORMANCE ANALYSIS (IPA)
Authors: Rachmadi Aditya , Harlambang Admaja Dewi , Ghaisani Nazomi Alifia
Published: September 2018

Competition between companies especially in e-commerce is increasingly fierce nowadays. ABC.com is a website that provides marketplace service, by providing better website it can improve service for their customer. This study aim to identify and prioritize factors that affect marketplace quality at ABC.com. The research approach used is quantitative approach with descriptive analysis. Sample selected from the population of user who have ABC.com account that amount to total 1.700..000 registered user  Sampling method used is convenience sampling that provide 109 respondent. Data collection is done through a questionnaire and provide factors that affect marketplace namely usability, information quality, service interaction quality, and user satisfaction. These factors is in the high category especially in indicator transaction and information security that placed in the A quadrant. While other indicators like performance, timeliness, purchase satisfaction and experience satisfaction placed in low priority (C quadrant). Recommendation for this study are ABC.com should increase their transaction process, information security and performance to obtain customer satisfaction in purchase activities that drive experience satisfaction.
KLASIFIKASI KUALITAS MUTU TELUR AYAM RAS BERDASARKAN FITUR WARNA DAN TEKSTUR
Authors: Sholihin Miftahus , Rohman M Ghofar
Published: September 2018

Egg quality is determined by the quality of the inside and outside of the egg. To find out the quality of eggs canbe by looking at the outside in the form of skin condition, shape, size, and egg weight. In this study a system isdesigned to function to determine the quality of egg quality based on color and texture features. Broadlyspeaking, the system built consists of 4 main processes. This process begins with pre-processing which aims toimprove image quality and also to change the image size. The next process is segmentation to get the egg object.The next process is feature extraction which aims to get the characteristics of each egg object. The last processis a classification that aims to determine the class of egg images entered by the user, the method used is knearest neighbor. The data used in this study were 147 egg images consisting of 85 eggs of data testing and 62eggs of training data. The highest accuracy obtained from this study is 82.3% with a value of 8
Implementasi Particle Swarm Optimization pada K-Means untuk Clustering Data Automatic Dependent Surveillance-Broadcast
Authors: Saidul Achmad , Buliali Joko Lianto
Published: September 2018

Investigasi kecelakaan penerbangan di Indonesia pada tahun 2010 sampai 2016 sebesar 212 investigasi. Hal tersebut dapat dihindari apabila ada sistem penerbangan yang dapat memastikan penerbangan berjalan aman, seperti sistem lalu lintas udara yang dapat mendeteksi apabila pesawat bergerak menuju ke arah yang salah. Penelitian ini bertujuan untuk mengelompokkan rute penerbangan pada data Automatic Dependent Surveillance-Broadcast menggunakan metode clustering untuk mendapatkan similaritas rute penerbangan. Penulis mengusulkan metode particle swarm optimization untuk mengoptimalkan metode k-means, yang berguna untuk menentukan titik centroid awal dengan silhouette coefficient sebagai fitness function. Hasil dari penelitian ini menghasilkan zona terbang berdasarkan kebiasaan sehingga dapat digunakan sebagai panduan penerbangan. Pengujian dilakukan dengan membandingkan nilai Davies-Bouldin index dengan metode k-means, k-medoids dan fuzzy c-means. Pada uji coba yang dilakukan, metode yang diusulkan menjadi kelompok metode terbaik pada lima dari enam segmen yang ada serta menghasilkan nilai Davies-Bouldin index lebih baik pada satu segmen sebesar 0,779.
Perancangan E-Resource Perpustakaan Menggunakan Customer Relationship Management Berbasis Mobile
Authors: Ningrum Putri Taqwa , Suria Ozzi , Witanti Arita
Published: September 2018

Perpustakaan adalah salah satu fasilitas yang membantu dalam penyediaan sumber daya dalam proses pendidikan, karena Perpustakaan menyediakan fasilitas pinjaman tanpa biaya. Perpustakaan dalam suatu Perguruan Tinggi memiliki peranan yang sangat penting bagi pembaca khususnya mahasiswa. Perpustakaan di Universitas Mercu Buana Yogyakarta memiliki minat baca cukup banyak. Hal ini dibuktikan melalui kuesioner yang dibagikan kepada 65 responden civitas akademik Mercu Buana Yogyakarta pada bulan Mei 2017, diperoleh hasil bahwa sebanyak 98.5% responden membutuhkan aplikasi perpustakaan digital. Responden dalam penelitian ini adalah mahasiswa aktif Universitas Mercu Buana Yogyakarta. Oleh karena itu dibutuhkan suatu sistem yang memungkinkan anggota perpustakaan untuk mengakses layanan perpustakaan secara online menggunakan aplikasi mobile berbasis iOS/Android. Hasil penelitian ini adalah perancangan e-Resource berbasis mobile untuk membaca dan menyimpan e-book yang dipinjam, transaksi meminjam tanpa biaya, akses repository tesis/skripsi, akses ke jurnal universitas, akses jurnal internasional, dan pembaharuan referensi yang cepat. Aplikasi IOS/Android perpustakaan juga akan menyediakan fasilitas untuk membantu pencarian buku yang dilakukan oleh anggota Perpustakaan dengan pilihan pencarian seperti judul, penulis, penerbit atau jenis buku. Pengembangan perangkat lunak yang di lakukan pada penelitian ini menggunakan metode Waterfall. Berbasis manajemen hubungan Customer Relationship Management (CRM) sebagai salah satu strategi peningkatan pelayanan yang berorientasi pada kebutuhan anggota. Salah satu karakteristik yang ingin ditonjolkan dari CRM adalah adanya interaksi antara penyedia layanan dan anggotanya. Dari interaksi tersebut, pihak penyedia layanan dapat menggali kebutuhan-kebutuhan para anggotanya untuk segera ditindaklanjuti. CRM mewakili kombinasi layanan teknologi dan informasi dengan tujuan untuk membangun sebuah sistem.
International Approaches to Regulation of Medicinal Products Containing Viable Human Cells
Authors: Melnikova E. V. , Goryaev A. A. , Savkina M. V. , Merkulova O. V. , Chaplenko A. A. , Rachinskaya O. A. , Semenova I. S. , Trusov G. A. , Merkulov V. A.
Published: September 2018

The intensive development of cellular technologies stipulates the introduction at the global level of medicinal products based on viable human cells, which in most countries are referred to as biomedical cell products. The authors conducted a comparative analysis of the regulatory framework in different countries and determined special aspects of regulation of cell therapy products (analogues of biomedical cell products). Some countries have mechanisms for priority review of cell therapy products for marketing authorization, such as accelerated assessment, accelerated approval, or conditional marketing authorisation. These mechanisms are currently absent in Russia, because of the novelty of the regulatory framework, and the biological properties of innovative cell products. Biomedical cell products are regarded as a separate class of medicinal products in Russia, they are not treated as biologicals and are regulated by the Federal Law No. 180-FZ «On Biomedical Cell Products» of June 23, 2016. The main difference in regulation of cell-based products in the Russian Federation is the principle of unified requirements for marketing authorisation of autologous, allogeneic, and combined biomedical cellular products, and the absence of the «hospital exemptions» mechanism that exists in many countries. This mechanism allows prescription and use of personalised autologous medicines produced in the laboratory of a medical institution for a particular patient.
Methodological Approaches to Validation of Therapeutic Recombinant Proteins Production Based on the Quality by Design Concept
Authors: Stratonova N. V. , Lisov A. S. , Morozov A. N. , Tyupa D. V. , Khamitov R. A.
Published: September 2018

Validation of production processes based on the Quality by Design (QbD) principles calls for thorough scientific understanding of the processes and enhancement of their stability by implementation of new technologies. The aim of the study consisted in substantiating a QbD-based technological approach to validation of commercial production of dornase alfa. For this purpose a design space was established in a scale-down model, i.e. 2 L reactors; the model was shown to be representative in terms of all parameters except for the reactor size; the similarity of hydrodynamic conditions, design characteristics and operation modes of laboratory, pilot and commercial scale reactors was established; the process scalability was demonstrated by using the PCA (Principal Component Analysis) multivariate mathematical model including the volume range of 2–1000 L, input and output process parameters and product quality attributes for a number of recombinant therapeutic products derived from the same CHO cell line and expression construction as dornase alfa producer. The article demonstrates the applicability of engineering space, which includes bioreactor design features and production process parameters, to different production scales by implementing 3 processes at the pilot scale (100 L) and 2 processes at the commercial scale (1000 L) and building a PCA model based on the obtained data.
Approaches to Pharmaceutical Analysis of Modern Peptide and Oligonucleotide Products as Illustrated by a Small Interfering RNA-Based Novel Therapeutic for the Treatment of Bronchial Asthma
Authors: Krasnykh L. M. , Smirnov V. V. , Ramenskaya G. V. , Vasilenko G. F. , Shilovsky I. P. , Haitov M. R.
Published: September 2018

Methods used to control the quality of peptide products depend on the level of development of analytical and bioorganic chemistry, and the level of instrumentation. Peptide identification is a difficult task and largely depends on the complexity of its structure. There does not exist a comprehensive and simple test, except for NMR, which, however, is rather expensive and time-consuming and involves complex data interpretations. Moreover, it does not allow for unambiguous determination of the peptide purity and formula (amino acid composition, sequence, chirality of amino acid residues). For this reason, a combination of methods is often used, including amino acid analysis, TLC/HPLC and mass spectrometry, and, less frequently, sequencing. Current international practice of peptide analysis is to use HPLC in combination with mass spectrometric, mainly tandem (HPLC-MS/MS), detection. According to literature sources the amino acid sequence of linear peptides can be analysed using various enzymes and subsequent identification of proteolysis products by mass spectrometry. This article presents approaches to the development of test methods for analysis of purity and identification testing of a small interfering RNA-based novel medicinal product, which will help standardise and control the quality of the production process.
Lesiones renales y pancreáticas inducidas por Ipomoea carnea en cabras
Authors: Rios E. , Cholich L. , Teibler G. , Bogado F. , Mussart N.
Published: September 2018

Ipomoea carnea es una planta tóxica debido a los alcaloides swainsonina y calisteginas, que provoca pérdidas económicas en la producción animal del nordeste argentino. El propósito de este estudio fue describir las lesiones microscópicas verificadas en páncreas y riñón, así como los cambios del perfil bioquímico renal causados por la intoxicación experimental con I. carnea en caprinos. Se emplearon 9 cabras alimentadas con alfalfa; 4 de ellas obraron como testigos y las 5 restantes fueron sometidas a la ingestión de hojas de I. carnea a razón de 50 g/kg/día durante 53 días, fecha en que fueron sacrificadas debido al grave deterioro de su salud. Semanalmente se realizaron exámenes clínicos y extracciones de sangre y orina. Urea y creatinina incrementaron progresivamente su concentración sérica en los animales intoxicados, quienes también revelaron anormalidades en el urianálisis. Los órganos más afectados fueron páncreas y riñón. Además de la vacuolización citoplasmática descripta por otros autores, en el presente estudio se constató la presencia de contenido eosinofilico intratubular y ensanchamiento del espacio de Bowman en los riñones, daños que explicarían las anormalidades detectadas en orina y sangre. Tales cambios asumen utilidad al momento de realizar el diagnóstico de esta intoxicación.
PERBAIKAN TATA LETAK PENYIMPANAN BARANG DI GUDANG UNTUK REDUKSI JARAK TEMPUH PERJALANAN MATERIAL HANDLING
Authors: Kartika Winanda , Helvianto Ahmad Wimbo
Published: September 2018

Gudang berperan sebagai distributor untuk menyalurkan produk menuju konsumen. Hal inilah yang dilakukan oleh PT.XYZ selaku warehouse outsourcing. PT XYZ mengelola sejumlah produk minuman yang diproduksi oleh suatu perusahaan multiinternasional PT ABC. Permasalahan yang dihadapi adalah gudang belum memiliki pengaturan mengenai tata letak penempatan produk sehingga penyusunan dilakukan secara acak tergantung blok penyimpanan yang kosong keseluruhan. Setiap blok penyimpanan di gudang ini hanya menampung satu jenis produk dan satu tanggal kadaluarsa, sehingga penempatan barang harus di blok yang kosong dan tidak memperhitungkan jarak tempuh perjalanan material handling dalam menyimpan dan mengambil barang. Selain itu, penyimpanan produk hanya bergantung pada daya ingat operator saja. Oleh karena itu, perlu dilakukan penataan ulang penempatan produk pada lokasi penyimpanan dengan kriteria performansi meminimasi total jarak tempuh perjalanan material handling. Usulan tata letak penempatan produk menerapkan metode dedicated storage yaitu suatu metode untuk penyelesaian masalah tata letak gudang mencakup penempatan produk di gudang berdasarkan banyaknya aktivitas keluar masuk produk di gudang dengan jarak tempuh terpendek terhadap pintu I/O. Dengan adanya penerapan metode ini, diharapkan produk yang akan disimpan menempati lokasi yang tetap untuk memudahkan operator dalam menyimpan dan mengambil produk. Hasil dari penerapan dedicated, diperoleh total jarak tempuh perjalanan sebesar 23719,36 m, sedangkan pada kondisi eksisting total jarak tempuh sebesar 27038,1 dengan persentase penurunan 12,27 %.
ANALISIS DAMPAK COMPONENT COMMONALITY TERHADAP SCHEDULE INSTABILITY PADA SISTEM RANTAI PASOK SEDERHANA
Authors: Ahmadi Bilal , Ratana Dhanny Surya
Published: September 2018

Penelitian ini menganalisis dampak penggunaan common component terhadap
ketidakpastian jadwal produksi. Analisis dilakukan pada penggunaan tingkat component
commonality (penggunaan komponen yang sama dalam struktur produk yang berbeda) tertentu
terhadap tingkat schedule instability pada sistem rantai pasok sederhana yang terdiri dari satu
pemanufaktur dan dua pemasok. Beragam kondisi operasional yang berbeda seperti:
ketidakpastian permintaan, cost structure, lead time, struktur produk serta kebijakan persediaan
yang diterapkan oleh perusahaan menjadi bagian yang diamati dalam studi ini. Hasil dari simulasi
menunjukkan penggunaan common component mampu mereduksi tingkat schedule instability,
baik pada pemanufaktur maupun pemasok. Selain itu juga tergambar dalam hasil tersebut bahwa
entitas pemasok mengalami instability yang lebih besar dibandingkan dengan pemanufaktur
SUPPLY CHAIN MANAGEMENT SUSTAINABILITY THROUGH THE PERFORMANCE IMPROVEMENT OF MTS-MTO PRODUCTION SYSTEM TYPOLOGY
Authors: Anissa Rizki
Published: September 2018

Batik has been acknowledged as a Masterpiece of Oral and Intangible Heritage of Humanity of Indonesia based on UNESCO in 2009 and this asset is considerably becoming the prospect to overcome global market in Asia. In the other side, the global competition can only be encountered by sustainably developing the internal industry. Therefore, this research elaborates sustainable supply chain performance assessment and also the improvement framework applied in Batik industry with MTO-MTS typology. For fulfilling the provisions of sustainability, the economic, environmental, and social is strictly important to be involved in. Supply Chain Operations Reference (SCOR) is a reference model of assessment considering five attributes to be measured and implemented as the perspective of economic assessment. Employee’s welfare and liquid waste assessment are then becoming the method to measure the social and environmental aspect. This resulted score as: Reliability is 89.24%, Responsiveness for MTS is 96% for MTO is 62%, Cost is 83.32%, Agility is 100%, and the Assets Management is 79.63%. For the social aspect, the score of parameter Health Insurance is 100%, Safety Tools is 100%, Basic Allowance is 70%, Annual Allowance is 100%, Appropriate Work Hours is 67%, and the Reward is 70%. For the environmental aspect, the temperature is 100%, pH 62.0%, BOD 100%, COD 64.7%, and TSS 7.4%. The improvement framework is also proposed by using Customer Order Decoupling Point (CODP) that results the increased performance in the Responsiveness attribute in the MTO process as much as 8.25%.
KEBIJAKAN PERSEDIAAN SUKU CADANG DI PT ABC MENGGUNAKAN METODE RCS (RELIABILITY CENTERED SPARES)
Authors: Dwi Atmaji Fransiskus Tatas , Utama Putra (Telkom University) Anak Agung Ngurah Nanda
Published: September 2018

Berdasarkan data dari bagian produksi dan bagian perawatan mesin, waktu berhenti beroperasi (downtime) untuk mesin JDK di PT.ABC adalah yang tertinggi. Tingginya downtime ini diakibatkan oleh tidak adanya spare part atau komponen pengganti saat mesin tersebut rusak sehingga waktu mesin berhenti semakin lama. Penelitian ini bertujuan untuk menganalisa dan menentukan kebijakan persediaan suku cadang, khususnya komponen-komponen kritis yang ada di mesin JDK. Metode Reliability Centered Spare (RCS) digunakan dalam penelitian ini, metode ini pada intinya bertujuan untuk menentukan kebijakan suku cadang yang optimal pada sebuah mesin dalam rentang periode tertentu. Hasil penelitian dengan metode RCS menunjukkan bahwa kebijakan persediaan suku cadang untuk semua komponen kritis mesin JDK dalam satu tahun ke depan adalah dengan melakukan penyimpanan atau persediaan komponen dengan sejumlah berikut: packing valve :469 buah; teflon:134 buah; bearing pump:10 buah; mechanical seal:26 buah; motor pump:10 buah; packing pump:141 buah;motor driving reel:9 buah; bearing driving reel:45 buah;mechanical seal driving reel:163 buah;packing heat exchanger:70 buah; site glass:29 buah; dan pressure gauge: 7 buah. 
PENGARUH GAYA KEPEMIMPINAN DAN MOTIVASI KERJA TERHADAP KINERJA PEGAWAI
Authors: Hanafi (Universitas Syah Kuala) Andhi Sukma , Almy (Management and Science University) Chairil , Siregar (Politeknik APP) M. Tirtana
Published: September 2018

Gaya kepemimpinan merupakan gaya yang digunakan oleh seorang pemimpin untuk memimpin organisasi dengan menggunakan sumber daya yang ada dalam organisasi untuk mencapai tujuan organisasi. Sumber daya manusia merupakan salah satu sumber daya yang ada dalam organisasi yang dapat dimanfaatkan pemimpin untuk pencapaian tujuan organisasi. Pegawai merupakan sumber daya manusia yang dapat dimanfaatkan oleh seorang pemimpin dalam mencapai tujuan organisasi. Dalam melaksanakan tugasnya dalam pencapaian tujuan organisasi, dapat diukur dengan tingkat kinerjanya. Tingkat kinerja merupakan perbandingan antara sasaran kerja yang ditetapkan dengan produktifitas kerja pegawai. Selain hal yang tersebut diatas, motivasi kerja juga sangat mempengaruhi perilaku pegawai dalam melaksanakan tugasnya yang berpengaruh terhadap tingkat kinerja. Motivasi kerja pegawai dipengaruhi dari internal dan eksternal. Salah satu pengaruh eksternal untuk peningkatan motivasi kerja pegawai berasal dari seorang pemimpin dalam menjalankan gaya kepemimpinannya. Gaya kepemimpinan yang sesuai dengan organisasi akan berpengaruh terhadap tingkat motivasi kerja pegawai, sehingga secara signifikan dapat meningkatkan kinerja pegawai dalam suatu organisasi.
Homestead tree species diversity and its impact on the livelihood of the farmers in Bangladesh
Authors: HAQUE Md Ahsanul , NAHER Nazmun , SULTANA Tania
Published: September 2018

The study was conducted in twelve villages of four unions under Gopalpur upazila in Tangail district of Bangladesh to explore the diversity of multipurpose tree species in the homesteads and its impact on the livelihood of the farmers in 2016. Study sites were selected purposively as the location. A total of 3334 farmers of the 12 villages constituted the population of study. A sample of 12% farm families was selected based on stratified random sampling procedure. Thus 400 farmers were selected. However, 80 farmers were selected from 400 sampled farmers by using Yamane formula. Therefore, these 80 farmers constitute the sample for this study. Five percent (0.05) level of probability was used as the basis for rejection of any null hypothesis throughout the study. Data for the study were collected through personal interview by the researcher himself during 15 May to 25 December, 2016 using the interview schedule. Farmer’s opinion regarding multipurpose tree species in the homesteads and its impact on socio-economic development was the dependent variables of the study. Ten characteristics are age, education, occupation, family member, farm size, homestead area, annual income, socio-economic aspects, knowledge on Multipurpose Tree Species (MPTs) in homestead agroforestry and problem confrontation constituted the independent variables of this study. Species diversity of MPTs in the homesteads agroforestry was measured by Shannon-wiener index (H). In case of all species, highest index (H) value found in Jhaoail union (H=3.017) and lowest index (H) value found in Dhopakandi union (H=2.967). Among these 75 different plant species, Akashmoni (12.53 %), Jackfruit (18.28 %), Neem (1.45%), Bamboo (3.72%), Mander (2.03%) were found as dominant trees for timber, fruit, medicinal, fodder and fuel wood species respectively. MPTs had direct impact on income of the farmers. Small farmers had average income 13.21 thousand taka, Medium farmers had average income 29.33 thousand taka and large farmers had average income 45.79 thousand taka from MPTs in homesteads.
Art Education Based on Joyful Learning Method and Information Communication Technology at Insan Mulia School of Nature Surabaya
Authors: Ismanto Idealita
Published: September 2018

This article discusses joyful learning method in Insan Mulia Surabaya School of Nature and describes ICT-based art education (Information and Communication Technology) at Insan Mulia School of Nature Surabaya. This research uses qualitative approach and descriptive research type. Data collection procedure is done by observation and interview method. Data analysis activities started from the data collection stage, the reduction phase, the data presentation stage, and the conclusion drawing stage. Data validation checks are performed with source triangulation, and method triangulation. The results of the study showed that: (1) Bina Insan Muliaâ€™s school education has a learning model of joyful learning (2) ICT-based arts education (Information and Communication Technology) to make student learning activities more interesting and not monotonous.Artikel ini membahas tentang metode pedidikan joyful learning di Sekolah Alam Insan Mulia Surabaya dan mendeskripsikan pendidikan seni berbasis ICT (Information and Communication Technology) di Sekolah Alam Insan Mulia Surabaya. Penelitian ini menggunakan pendekatan kualitatif dan jenis penelitian deskriptif. Prosedur pengumpulan data dilakukan dengan metode observasi dan wawancara. Kegiatan analisis data dimulai dari tahap pengumpulan data, tahap reduksi, tahap penyajian data, serta tahap penarikan kesimpulan. Pengecekan keabsahan data dilakukan dengan triangulasi sumber, dan triangulasi metode. Hasil penelitian menunjukkan bahwa: (1) pendidikan sekolah alam Bina Insan Mulia memiliki model pembelajaran joyful learningÂ  (2) pendidikan seni berbasis ICT (Information and Communication Technology) membuat kegiatan belajar siswa lebih menarik dan tidak monoton.
Polynomial Optimization and Quantifier Elimination in Quantum Mechanics
Authors: Kikuchi Ichio , Kikuchi Akihito
Published: September 2018

In this short notes, we present the formulation of a kind of quantum algorithm, applicable to the polynomial optimization. The present algorithm introduces the quantum effect by means of the coordinate variables, the momentum variables, and the commutators, and the Plank constant, which shall establish the correspondence between the quantum and the classical cases. The formalism is an extension to the polynomial optimization in the ``classical'' sense; the relations among quantum mechanical values are represented by a semi-algebraic set ( by the set of polynomials and sign conditions), and the optimum is searched in this semi-algebraic set. In the context of this formalism, the optimization of the Ising model [QUBO model] will be a special case. However, the computational procedure proposed here is different from the quantum annealing which is now in vogue. We demonstrate the exemplary calculation through quantifier elimination (which is a kind of symbolic computation applicable to optimization and other problems).
MERENCANAKAN MASA DEPAN (Sumbangsih Pemikiran Bagi Pengembangan Manajemen Pelayanan Publik di Lembaga Layanan Pendidikan Tinggi Wilayah XII, Maluku dan Maluku Utara)
Authors: Nanuru Ricardo Freedom
Published: September 2018

Opini ini dimuat pada Buletin Dinamika: Media Informasi dan Komunikasi Kopertis Wilayah XII Maluku dan Maluku Utara, Vol.1 Edisi 2 Tahun 2018, p. 22-23; ISSN: 2620-5289. Judul Opini ini adalah MERENCANAKAN MASA DEPAN (Sumbangsih Pemikiran Bagi Pengembangan Manajemen Pelayanan Publik di Lembaga Layanan Pendidikan Tinggi Wilayah XII, Maluku dan Maluku Utara). Dibuat dengan tujuan memberikan masukan bagi pengembangan LLDIKTI Wilayah XII demi perbaikan pelayanan ke depan.
Memristors for the curious outsiders
Authors: Carbajal Juan Pablo , Caravelli Francesco
Published: September 2018

We present both an overview and a perspective of recent experimental advances and proposed new approaches to performing computation using memristors. A memristor is a 2-terminal passive component with a dynamic resistance depending on an internal parameter. We provide an brief historical introduction, as well as an overview over the physical mechanism that lead to memristive behavior. This review is meant to guide nonpractitioners in the field of memristive circuits and their connection to machine learning and neural computation.
Komunisme: Sikap di Hulu dan di Hilir
Authors: Siregar Shohibul Anshor
Published: September 2018

Situasi ini sebenarnya sudah menggiring rakyat dengan pembelahan sistematis dan ini sangat mudah melahirkan tikai horisontal. Jika yang dimobilisasi melawan komunisme itu adalah umat beragama, maka secara internal agama-agama itu pun akan mengalami keterpilahan penganut yang parah pula. Antara satu dan lain agama (Islam, Protestan, Katholik, Hindu, Budha dan Kong Hu Chu) pastilah akan berbeda pula penyikapannya berhubung temali sejarah konflik perebutan “hak asuh atas Negara” dan konten pemahaman teologisnya masing-masing.
Pengistimewaan Mafia Pajak
Authors: Siregar Shohibul Anshor
Published: September 2018

Apa pun alasannya, sulit untuk tidak melihat sisi buruk rencana tax amnesty (pengampunan pajak) yang kini sedang dibincangkan secara nasional. Itu sangat mengganggu. Sebuah proses legitimasi hukum membentang karpet merah kepada para mafia pajak, menjadikannya pahlawan dan mengistimewakannya di antara warga Negara.
Pesanteren
Authors: Siregar Shohibul Anshor
Published: September 2018

Indonesia. Tak Cuma sebuah negeri berbhinneka Tunggal Ika dan tak lengkap juga jika tak disebutkan sebagai negeri berpenduduk mayoritas muslim (SP 2010 oleh BPS menyebut umat Islam mencapai 87,16%). Dunia mencatat itu.
Jihad Kontemporer
Authors: Siregar Shohibul Anshor
Published: September 2018

Agenda pertama jihad kontemporer adalah “perang” terhadap segenap bentuk kejahatan, baik berupa rencana maupun tindakan, dalam penggunaan terminologi “jihad”. Teror verbal yang berlangsung selama ini telah memaksa orang menjadi ragu atas pakem kehidupannya sendiri, karena dengan menyimpangkan terminologi jihad tampaknya diinginkan korban komunitas besar.
Ilusi Good Governance
Authors: Siregar Shohibul Anshor
Published: September 2018

Sebelum menjadi wacana internasional yang secara otoritatif “dipaksakan” ke seluruh dunia pada dekade 1990-an, terminologi Good Governance (GG) pertama kali diperkenalkan oleh Bank Dunia (BD) dalam publikasinya (1989) berjudul Sub Saharan Africa: From Crisis to Sustainable Growth. BD memang sangat agresif mengkampanyekan konsep GG, bahkan memaksa dilakukannya penyesuaian-penyesuaian kelembagaan sebagai prasyarat mendapatkan bantuan pembangunan. Setiap negara wajib tunduk pada kriteria yang dibuat, dan para konsultan ditugasi untuk memperlancar proses itu.
PENGARUH KOMITMEN PROFESIONAL DAN KEPUASAN KERJA TERHADAP TURNOVER INTENTION (Studi Empiris pada Kantor Akuntan Publik di Jawa Timur)
Authors: Awalina Putri
Published: September 2018

ABSTRAKPenelitian ini bertujuan untuk membuktikan pengaruh komitmen profesional dan kepuasan kerja terhadap turnover intention. Variable komitmen profesional terdiri dari tiga dimensi yaitu Affective Professional Commitment, Continuance Professional Commitment, dan Normative Professional Commitment. Penelitian ini menggunakan metode survei dalam pengambilan data dan diolah dengan menggunakan smartPLS.Hasil penelitian ini adalah turnover intention pada KAPditentukan oleh komitmen profesional yang terdiri dari affective professional commitment dan continuance professional commitment, serta kepuasan kerja auditor. Penelitian ini tidak berhasil membuktikan bahwa turnover intention ditentukan oleh normative professional commitment.Kata kunci: Affective Professional Commitment, Continuance Professional Commitment, Normative Professional Commitment, Kepuasan Kerja, Turnover Intention