bluuebunny/crossref_metadata_2025 huggingface dataset:
Thyroid hormone levels paradox in acute ischemic stroke
Authors: Xie Chunhui , Jiang Yi , Shen Xiaozhu , Liu Mengqian , Xu Yiwen , Zhong Wen , Ge Zhonglin , Qian Mingyue , Dong Nan , Gong Chen , Zhang Guanghui
Published: June 2023

Objective

Accumulating evidence has suggested that thyroid hormone levels affect the prognosis of acute ischemic stroke (AIS), but the results have been inconsistent.

Methods

Basic data, neural scale scores, thyroid hormone levels, and other laboratory examination data of AIS patients were collected. The patients were divided into excellent and poor prognosis group at discharge and 90 days after discharge. Logistic regression models were applied to evaluate the relationship between thyroid hormone levels and prognosis. A subgroup analysis was performed based on stroke severity.

Results

A number of 441 AIS patients were included in this study. Those in the poor prognosis group were older, with higher blood sugar levels, higher free thyroxine (FT4) levels, and severe stroke (all p < 0.05) at baseline. Free thyroxine (FT4) showed a predictive value (all p < 0.05) for prognosis in the model adjusted for age, gender, systolic pressure, and glucose level. However, after adjustment for types and severity of stroke, FT4 showed insignificant associations. In the severe subgroup at discharge, the change in FT4 was statistically significant (p = 0.015), odds ratio (95% confidence interval) = 1.394 (1.068–1.820) but not in the other subgroups.

Conclusions

High-normal FT4 serum levels in patients with severe stroke receiving conservative medical treatment at admission may indicate a worse short-term prognosis.
Excitatory and Inhibitory Descending Commissural Interneurons Differentially Integrate Supraspinal and Segmental Sensory Signals
Authors: Giorgi Andrea , Cer Abishag Tluang , Mohan Shruthi , Perreault Marie-Claude
Published: June 2023

The limited information about how descending inputs from the brain and sensory inputs from the periphery use spinal cord interneurons (INs) is a major barrier to understanding how these inputs may contribute to motor functions under normal and pathologic conditions. Commissural interneurons (CINs) are a heterogeneous population of spinal INs that has been implicated in crossed motor responses and bilateral motor coordination (ability to use the right and left side of the body in a coordinated manner) and, therefore, are likely involved in many types of movement (e.g., dynamic posture stabilization, jumping, kicking, walking). In this study, we incorporate mouse genetics, anatomy, electrophysiology, and single-cell calcium imaging to investigate how a subset of CINs, those with descending axons called dCINs, are recruited by descending reticulospinal and segmental sensory signals independently and in combination. We focus on two groups of dCINs set apart by their principal neurotransmitter (glutamate and GABA) and identified as VGluT2+ dCINs and GAD2+ dCINs. We show that VGluT2+ and GAD2+ dCINs are both extensively recruited by reticulospinal and sensory input alone but that VGluT2+ and GAD2+ dCINs integrate these inputs differently. Critically, we find that when recruitment depends on the combined action of reticulospinal and sensory inputs (subthreshold inputs), VGluT2+ dCINs, but not GAD2+ dCINs, are recruited. This difference in the integrative capacity of VGluT2+ and GAD2+ dCINs represents a circuit mechanism that the reticulospinal and segmental sensory systems may avail themselves of to regulate motor behaviors both normally and after injury.

SIGNIFICANCE STATEMENTThe way supraspinal and peripheral sensory inputs use spinal cord interneurons is fundamental to defining how motor functions are supported both in health and disease. This study, which focuses on dCINs, a heterogeneous population of spinal interneurons critical for crossed motor responses and bilateral motor coordination, shows that both glutamatergic (excitatory) and GABAergic (inhibitory) dCINs can be recruited by supraspinal (reticulospinal) or peripheral sensory inputs. Additionally, the study demonstrates that in conditions where the recruitment of dCINs depends on the combined action of reticulospinal and sensory inputs, only excitatory dCINs are recruited. The study uncovers a circuit mechanism that the reticulospinal and segmental sensory systems may avail themselves of to regulate motor behaviors both normally and after injury.
Instant Effects of Semantic Information on Visual Perception
Authors: Enge Alexander , Süß Franziska , Abdel Rahman Rasha
Published: June 2023

Does our perception of an object change once we discover what function it serves? We showed human participants (n= 48, 31 females and 17 males) pictures of unfamiliar objects either together with keywords matching their function, leading to semantically informed perception, or together with nonmatching keywords, resulting in uninformed perception. We measured event-related potentials to investigate at which stages in the visual processing hierarchy these two types of object perception differed from one another. We found that semantically informed compared with uninformed perception was associated with larger amplitudes in the N170 component (150-200 ms), reduced amplitudes in the N400 component (400-700 ms), and a late decrease in alpha/beta band power. When the same objects were presented once more without any information, the N400 and event-related power effects persisted, and we also observed enlarged amplitudes in the P1 component (100-150 ms) in response to objects for which semantically informed perception had taken place. Consistent with previous work, this suggests that obtaining semantic information about previously unfamiliar objects alters aspects of their lower-level visual perception (P1 component), higher-level visual perception (N170 component), and semantic processing (N400 component, event-related power). Our study is the first to show that such effects occur instantly after semantic information has been provided for the first time, without requiring extensive learning.

SIGNIFICANCE STATEMENTThere has been a long-standing debate about whether or not higher-level cognitive capacities, such as semantic knowledge, can influence lower-level perceptual processing in a top-down fashion. Here we could show, for the first time, that information about the function of previously unfamiliar objects immediately influences cortical processing within less than 200 ms. Of note, this influence does not require training or experience with the objects and related semantic information. Therefore, our study is the first to show effects of cognition on perception while ruling out the possibility that prior knowledge merely acts by preactivating or altering stored visual representations. Instead, this knowledge seems to alter perception online, thus providing a compelling case against the impenetrability of perception by cognition.
Human mitochondrial ADP/ATP carrier SLC25A4 operates with a ping‐pong kinetic mechanism
Authors: Cimadamore‐Werthein Camila , Jaiquel Baron Stephany , King Martin S , Springett Roger , Kunji Edmund RS
Published: June 2023

The mitochondrial ADP/ATP carrier (SLC25A4), also called the adenine nucleotide translocase, imports ADP into the mitochondrial matrix and exports ATP, which are key steps in oxidative phosphorylation. Historically, the carrier was thought to form a homodimer and to operate by a sequential kinetic mechanism, which involves the formation of a ternary complex with the two exchanged substrates bound simultaneously. However, recent structural and functional data have demonstrated that the mitochondrial ADP/ATP carrier works as a monomer and has a single substrate binding site, which cannot be reconciled with a sequential kinetic mechanism. Here, we study the kinetic properties of the human mitochondrial ADP/ATP carrier by using proteoliposomes and transport robotics. We show that the Km/Vmax ratio is constant for all of the measured internal concentrations. Thus, in contrast to earlier claims, we conclude that the carrier operates with a ping‐pong kinetic mechanism in which substrate exchange across the membrane occurs consecutively rather than simultaneously. These data unite the kinetic and structural models, showing that the carrier operates with an alternating access mechanism.
Adjuvant and neoadjuvant therapy with cyclin-dependent kinase 4 and 6 inhibitors in hormone receptor-positive, human epidermal growth factor receptor 2-negative early breast cancer: a systematic review and meta-analysis
Authors: Zhang Meilin , Song Jian , Guo Shigang , Jin Feng , Zheng Ang
Published: June 2023

Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors have shown advantages in hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2−) advanced breast cancer. This study aimed to evaluate the efficacy and safety of CDK4/6 inhibitors combined with endocrine therapy (ET) in patients with HR+, HER2− early breast cancer. The PubMed, Embase, Cochrane Library, and Web of Science databases were searched for randomized controlled trials (RCTs) related to CDK4/6 inhibitors combined with ET. Literature conforming to the research content was identified according to the inclusion and exclusion criteria. The efficacy endpoints included invasive disease-free survival (IDFS), distant relapse-free survival (DRFS), and overall survival (OS) with adjuvant therapy. The efficacy endpoint of neoadjuvant therapy was complete cell cycle arrest (CCCA). The safety outcomes included the incidence of adverse events (AEs) and grade 3–4 hematological and non-hematological AEs. Data analysis was performed using Review Manager software (version 5.3). A statistical model (fixed-effects model or random-effects model) was selected based on the level of heterogeneity, and a sensitivity analysis was performed if strong heterogeneity existed. Subgroup analyses were performed based on the baseline patient characteristics. Nine articles (including six RCTs) were included in the study. In adjuvant therapy, compared with the control group, CDK4/6 inhibitors combined with ET showed no statistically significant difference in IDFS (hazard ratio = 0.83, 95% confidence interval (CI) = 0.64–1.08, P = 0.17) and DRFS (hazard ratio = 0.83, 95% CI = 0.52–1.31, P = 0.42). In neoadjuvant therapy, CDK4/6 inhibitors combined with ET significantly improved CCCA compared with the control group (odds ratio = 9.00, 95% CI = 5.42–14.96, P < 0.00001). In terms of safety, the combination treatment group had a significantly increased incidence of grade 3–4 hematological AEs in patients, especially grade 3–4 neutropenia (risk ratio (RR) = 63.90, 95% CI = 15.44–264.41, P < 0.00001) and grade 3–4 leukopenia (RR = 85.89, 95% CI = 19.12–385.77, P < 0.00001), with statistically significant differences. In patients with HR+, HER2− early breast cancer, the addition of CDK4/6 inhibitors may prolong IDFS and DRFS in adjuvant therapy, especially in high-risk patients. Further follow-up is needed to establish whether OS can be improved with CDK4/6 inhibitors plus ET. CDK4/6 inhibitors also showed effective anti-tumor proliferation activity in neoadjuvant therapy. Regular monitoring of routine blood tests in patients using CDK4/6 inhibitors is essential.
Quality Improvement: A Template-Based Approach to HEADSS Assessments for Hospitalized Adolescents
Authors: Wiley Evan , Kulkarni Deepa , Dong Huan , Hwang Loris Y.
Published: June 2023

BACKGROUND

Hospitalizations are opportunities to screen adolescents for risk behaviors, but screening occurs infrequently. At our institution, adolescent inpatients on pediatric services have an array of medical acuity and complexity, and only 11% had complete home; education; activities; drug, alcohol, and tobacco use; sexual history; and self-harm, suicidality, and mood (HEADSS) histories. The aim of this quality improvement project was to increase the HEADSS completion rate to 31% within 8 months of the initial Plan-Do-Study-Act cycle.

METHODS

A working group identified key drivers of incomplete HEADSS histories. Interventions focused on creating and modifying note templates to encourage providers to obtain and document HEADSS histories, sharing data with providers, and educating providers. The primary outcome measure was the percent of patients with a complete HEADSS history. Process measures included use of a confidential note, documentation of a sexual history, and number of domains documented. The balancing measure was patients with no social history documented.

RESULTS

A total of 539 admissions were included, 212 in the baseline period and 327 in the intervention period. The percent of patients with a complete HEADSS history increased from 11% to 39%. Use of a confidential note increased from 14% to 38%, documentation of a sexual history increased from 18% to 44%, and average number of domains documented increased from 2.2 to 3.3. The number of patients with no social history documented was unchanged.

CONCLUSIONS

A quality improvement initiative using note templates can significantly increase the rate of complete HEADSS history documentation in the inpatient setting.
Takwil Al-Qur’an Syi’ah Isma’iliyah: Studi Penakwilan pada Kisah Nabi Isa As
Authors: Dzikrillah Alfani Ilzam Hubby
Published: June 2023

This research is about the Shia Sect. The development of Shia is divided into three, including: Itsna 'Asyariyah, Isma'iliyah and Zaidiyah. Shia Isma'iliyah is the second largest sect. The development of Shia is very rapid but requires a long and complex time. The interpretation that is very popular among the Shia is the Tafsir Asas al-Ta'wil. The purpose of this research is to popularize the rarely known Shia interpretation. This research provides an overview of the Ismaili Shia figures, the meaning of ta’wil and the difference with the term tafsir. Then, covered with examples of interpretation of the story of Prophet Isa As. This type of research is classified as qualitative by relying on written data. The result of this research and discussion is that the book Tafsir Asas al-Ta’wil by al-Nu'man ibn Hayyun is the basic basis of mysticism philosophy as an understanding of a nature contained in the Al-Qur’an. It is divided into six sections which interpret the stories of the prophets in the Al-Qur’an, including: Prophet Adam, Prophet Noah, Prophet Abraham, Prophet Musa, Prophet Isa, and Prophet Muhammad SAW. The concept of ta'wil according to Syi'ah Isma'iliyah is an attempt to find the inner meaning or sign, essence, and truth (meaning) that is hidden behind the lafadz. There are many shortcomings in this research. Therefore, Drivers of Islamic Studies are expected to continue to deepen research related to the Ismaili Shia Theme.
Between Thankfulness and Love
Authors: Vanderleek Ethan
Published: June 2023

Philosophers in the 20th and 21st centuries have offered criticisms of the excesses of human use over the natural world and emphasized how use is increasingly controlled by technological determinism. Martin Heidegger and Michel Henry have contributed to this line of criticism, but both fall short in their critiques and recommendations because they lack a robust notion of transcendence. The philosophy of William Desmond, however, provides a historical and systematic account of human use that critiques modern culture and provides ethical and religious trajectories for addressing ecological destruction by unfettered human use. For Desmond, use must be oriented beyond itself in thankfulness for the transcendent source of what is used and in self-transcending love towards a transcendent end beyond what is used. Though humans cannot help but use the natural world, a rich account of thankfulness and love provide a ground for human use that prevents anthropocentric abuse.
Gerçek ve Mit Arasında Abdullah el-Battal
Authors: ERBAY Enes Ensar , YALÇIN Mehmet Fatih
Published: June 2023

Abdullah el-Battal, Emevîler döneminde (41-132/661-750) İslâm fetihlerinde önemli görevler üstlenen bir komutandır. Onun tarihî kişiliği ve seferleri göz önünde bulundurulduğunda bu durum açıkça ifade edilebilir. Bu görevlerde Battal’ın, Bizans (Doğu Roma) İmparatorluğu’na karşı kayda değer bir başarıya ulaştığı, söz konusu başarının onun kroniklerde bir kahraman olarak anılmasına neden olduğu anlaşılmaktadır. Bu makalede, Anadolu topraklarına (Bilâdü’r-Rûm) sefer düzenleyen Abdullah el-Battal’ın tarihsel varlığının kahraman anlatısına dönüşme süreci ve bunu besleyen temel unsurlar irdelenmektedir. İlk dönem İslâm tarihi kaynakları çerçevesinde yapılan bu inceleme, özellikle İbn A‘sem’in (ö. 320/932’den sonra) Kitâbü’l-fütûḥ ve İbn Asâkir’in (ö. 571/1176) Târihu medineti Dımaşḳ isimli eserlerindeki anlatı unsurları üzerinden ele alınmaktadır. Her iki müellifin Battal’ı kahraman olarak sundukları, bu doğrultuda konu edindikleri içeriklerinden anlaşılmaktadır. Müelliflerin Battal’a dair sundukları tasvirlerde yaşadıkları çağın siyasî vaziyeti, mezhebî kimlikleri ve otorite ile kurdukları ilişkinin belirleyici olduğu söylenebilir. Bu çerçevede öncelikle Battal’ın hayatı, seferleri ve katıldığı cihad hareketleri, akabinde ise kahramanlaşarak anlatıya makalenin temel odak noktalarını oluşturmaktadır.
The Slavs in the Hungarian Chronicles
Authors:   Instytut Slawistyki PAN, Grzesik Ryszard
Published: June 2023

The article describes the way of presentation of the Slavs in the Hungarian medieval chronicles. They were only a background for the Hungarians as the subjugated population, therefore the Slavic tradition was generally uninteresting for the Hungarians. The Sclavi were one of the Slavic tribes only, identical to the Pannonian Slavs.
Litterati w otoczeniu Władysława Łokietka około 1320 r.
Authors:   Uniwersytet Jagielloński, Ożóg Krzysztof
Published: June 2023

The article presents a group of 26 litteratorum (clerics with university education) and their activities in the diplomacy and monarchical chancellery of Vladislaus the Short, and in the Polish-Teutonic trial between 1314 and 1323.
Instructional Strategies in Developing Critical Thinking Skills in Non-Formal Secondary Education in Tanzania
Authors: Michael Tulia , Ephrem Abdon
Published: June 2023

This study examined the contribution of instructional strategies in developing critical thinking skills in non-formal secondary education in Tanzania. The study was carried out in Kinondoni Municipal council in Tanzania. Qualitative approach with phenomenology design was employed in this study. The study sample comprised 36 learners and 8 teachers that make total of 44 participants. The study used purposeful sampling to all participants. Methods used to collect data in this study were interviews, focused group discussions and observations. This study employed thematic analysis to analyze the data. The study findings indicated that there was limited use of instructional strategies had showed to have little contribution of developing critical thinking skills among learners. These strategies include lecture, questions and answers, oral presentation, group discussion and problem-solving that had low contribution in developing critical thinking among learners in non-formal secondary education. The study further revealed that most of the people who were teaching were not qualified to be teachers; this lead also to very low contribution of developing critical thinking among learners. The study recommends that teachers should use adequate interactive instructional strategies that may have great contributions in developing critical thinking among learners such as questions and answers strategy, group discussion, oral presentation, problem solving, research activities, field work, exposing learners to libraries, provisional of triggering questions, puzzling questions and promoting self-independent learning.
The pedagogical thought of Mozi and the Moist school
Authors: Zieliński Paweł
Published: June 2023

This paper attempts to reconstruct the pedagogical thought of Mozi and the Moist school, the preeminent ancient philosophical school in China, along with Daoism and Confucianism. The research refers to the work of Mozi and studies by contemporary experts on his philosophy. The basic pedagogical values or virtues identified by the philosopher are universal love, security (economic),peace, simplicity, modesty, self-restraint (of material needs), social activism, high morale of leaders and superiors. The fundamental dilemma of the Moist concept comes down to the state and religious sanctioning of the pedagogical virtues listed, which in the light of contemporary pedagogical research undermines the value of the concept.
Physical education and sports-experienced tourism during the education period of Petro Bubela’sat the Academic gymnasium in Lviv (1900–1908)
Authors: Prokip Andrij , Mykhalskyj Yuriy
Published: June 2023

During 1900-1908, Petro Bubela (the future leading statesman and military figure of the Western Ukrainian People's Republic) studied at the Lviv Academic Gymnasium. During his studies at the gymnasium, he was involved in the gymnasium educational process in physical education, got acquainted with advanced achievements and methods in the field of physical education, participated in sports and recreation, educational tourism events organized by gymnasium teachers. Thanks to gymnasium teachers such as Ivan Boberskyi, Stepan Rudnytskyi, Longyn Tsegelskyi, etc., sports and tourism increasingly became an important element in the formation of gymnasium students as spiritually, physically hardened and developed personalities, ready to fight for Ukrainian statehood.
Age and sex effects on SuperG performance are consistent across internet devices
Authors: Hooyman Andrew , Schaefer Sydney
Published: June 2023

There have been recent advances in the application of online games that assess motor skill acquisition/learning and its relationship to age and biological sex, both of which are associated with dementia risk. While this online motor learning assessment (called Super G), along with other computer-based cognitive tests, was originally developed to be completed on a computer, many people (including older adults) have been shown to access the internet through a mobile device. Thus, to improve the generalizability of our online motor skill learning game, it must not only be compatible with mobile devices but also yield replicable effects of various participant characteristics on performance relative to the computer-based version. It is unknown if age and sex differentially affect game performance as a function of device type (keyboard versus touchscreen control). Thus, the purpose of this study was to investigate if device type modifies the established effects of age and sex on performance. Although there was a main effect of device on performance, this effect did not alter the overall relationship between performance vs. age or sex. This establishes that Super G can now effectively be extended to both computer and mobile platforms to further test for dementia risk factors
İlim Bölümleri Üzerinden Dârimî ve Buhârî’nin İlim Anlayışını Okumak
Authors: Uysal Şule Yüksel
Published: June 2023

Tasnif döneminin önemli eserlerinden biri Buhârî’nin (öl. 256/870) el-Câmiu’s-Sahîh’i diğeri de Dârimî’nin (öl. 255/869) daha çok Sünen ismiyle meşhur olmuş el-Müsned isimli eseridir. Buhârî’nin eseri sahihleri toplama amacıyla kaleme alınan ilk eser olmak, Dârimî’nin eseri ise bazı alimlerce İbn Mâce’nin (öl. 273/887) eseri yerine Kütüb-i Sitte’nin altıncı eseri olmaya layık görülmek bakımından büyük önemi haizdir. Bu iki temel eserin ilim bölümleri özellikle Ehl-i Hadis’in ilim anlayışını anlamlandırmak için kilit işlev görmektedir. Çünkü Buhârî’nin eserine hadis dünyası haklı olarak büyük kıymet vermiş, Dârimî ise İlim bölümünü literatürdeki en geniş İlim bölümü olarak şekillendirmiştir. İlim kavramının dinamikliği, farklı ilim dallarına göre farklılığı ve tarihi süreçteki değişimi bilinen bir durumdur. Ehl-i Hadis diğer ekollerden farklılaşan ilim anlayışlarını, rivayet kitapları içinde nakiller aracılığı ile ortaya koymuştur. Onların rivayetleri derledikleri eserlerde İlim konulu bölümler açması kendi bakış açılarıyla ilmin ne olduğunu rivayetler üzerinden sunma çabasının ürünüdür. Bu bölümler bir taraftan ilmin ne olduğunu ortaya koyarken diğer yandan ilmin ne olmadığını ifade etmekte, bu yönüyle dönemin ehl-i re’y’ine reddiye içeriği de sunabilmektedir. Çalışma, iki eserin ilgili bölümleri aracılığı ile aynı ekoldeki iki müellifin ilim anlayışlarının ortak ya da farklı yönlerini ortaya koymayı hedeflemektedir. İki bölümün hadislerinin sayısı, türleri, konu içerikleri ve bab başlıkları mukayese edilerek bir sonuca ulaşılacaktır. Makale iki müellifin ilim anlayışlarının temelde benzeşmekle beraber gerek konu seçimi gerekse kullandıkları rivayetler ve bab başlıkları itibariyle farklılaştıkları alanlar olduğunu da ortaya koymuştur.
Haritalama ve Mekân Kavramından Hareketle Jean Baudrillard’ın Simülasyon Kuramı
Authors: Odabaş Yusuf
Published: June 2023

Jean Baudrillard “Simülasyon teorisi” olarak bilinen teorisi ile yaşadığımız çağın kitle zihni üzerine analizlerde bulunmuştur. Her ne kadar kritiklerini yaşadığımız çağa yönlendirse dahi simülasyon teorisini Rönesans ve Sanayi Devrimi ile başlayan bir süreçte tarihlendirmiştir. Üç yüz yıllık bir süreci içine alan bu tarihlendirme doğal olarak simülasyon kuramının neye karşılık geldiğinin anlaşılmasını zorlaştırmaktadır. J. Baudrillard’ın bu süreci üç ana bölüme ayırması ile simülasyon teorisinin bu üç bölümde nasıl bir işlev gördüğünün kritiği önem kazanmıştır. Bu süreçlerin ayrıntılı analizi eserlerinde bulunmasa dahi J. Baudrillard’ın simülasyon teorisini açıklamak için kullandığı “harita” benzetmesi bu süreçlerde simülasyonun nasıl bir işlev gördüğüne dair ipuçları barındırmaktadır. Zira haritalama belirli bir dönemin düşünme yapısını içerdiği gibi o dönemin mekân algısına da işaret edebilen kritik bir kavramdır. Bu ipuçlarını takip ederek simülasyonun hem tarihsel gelişimini takip edebilir hem de günümüzde nasıl bir mekân analizi sunduğunu kritik edebiliriz. Çalışmamız J. Baudrillard’ın belirttiği tarihsel dönemlerin düşünce karakterlerini harita kavramıyla analiz ederek bu düşünce dönemleri ile simülasyon kuramının mekân anlayışının karşılıklı analizlerini yapmayı ve dolayısıyla günümüzde simülasyon kavramının nasıl bir dünyaya karşılık geldiğini kritik etmeyi amaçlamaktadır.
Effectiveness of lip repositioning in the treatment of excessive gingival display: systematic review and meta-analysis
Authors:   Department of Clinical Dentistry, Pathology and Oral Surgery, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil., Couto e Silva Juliana , Guimarães Abreu Lucas ,   Department of Paediatric Dentistry, Pathology and Oral Surgery, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil., Araújo Cunha Fabiano ,   Department of Clinical Dentistry, Pathology and Oral Surgery, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil., Lopes Freire Bárbara ,   Department of Clinical Dentistry, Pathology and Oral Surgery, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil., Esteves Lima Rafael Paschoal ,   Department of Clinical Dentistry, Pathology and Oral Surgery, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Published: June 2023

Background: The objective of this systematic review and meta-analysis was to answer the questions ‘’Does lip repositioning surgery reduce the amount of gingiva exposed in the smile in individuals with excessive gingival display EGD (excessive gingival display)?’’ and ‘’Is the reduction of the amount of gingiva exposed when smiling obtained with lip repositioning surgery stable over time?’’ to evaluate the effectiveness of lip repositioning surgery for correcting EGD on smiling. Materials and Methods: A systematic structured search was carried out in five databases without data restriction. Studies reporting the degree of reduction in gingival ex-posure after lip repositioning surgery were included. Study selection, data extraction, and risk of bias assessment were performed in duplicate Results: One hundred sixty-four references were retrieved and eleven studies met the eligibility criteria. Meta-analysis demonstrated that lip repositioning surgery results in a significant reduction in the amount of exposed gingival tissue (mean difference = -3.03; confidence interval = -3.55; -2.52). In addition, the results remained stable in the evaluated follow-up periods (1, 3, 6 and 12 months). Included studies had a low risk of bias. Conclusions: Lip repositioning surgery is effective for the treatment of EGD on smiling and exhibits stable results in the evaluated periods. The study was registered (CRD42020184866) in the international prospective register of systematic reviews (PROSPERO). Keywords: Lip; Gingiva; Smiling; Lip repositioning; Excessive gingival display; Esthetic periodontal surgery
Mülteci Öğrencilerin Eğitim Sorunlarının İncelenmesi: Yozgat İli Örneği
Authors: SALI Güneş , ŞEKER Samed
Published: June 2023

Yozgat ilinde yaşayan mülteci öğrencilerin eğitim sorunları ve getirilecek çözüm önerilerinin incelenmesi amacıyla yapılan bu araştırma, nitel bir çalışmadır. Araştırmanın amacı kapsamında oluşturulan çalışma grubu, Türkiye’ye göç etmiş ve halen Yozgat ilinde yaşayan il merkezindeki ortaokullara ve liselere devam eden 24 mülteci öğrenci, 18 öğretmen, 2 rehber öğretmen ve 5 okul yöneticisi olmak üzere toplam 49 katılımcıdan oluşmaktadır. Araştırmada veri toplama aracı olarak yarı yapılandırılmış görüşme formu kullanılmıştır. Araştırma sonucunda; mülteci öğrencilerin Türkiye’ye göç etme nedenlerinin başında, geldikleri ülkede savaş olması ve maddi imkansızlıkların yaşanması gelmektedir. Yozgat’ta yaşayan mülteci öğrencilerin genel sorunlarının başında dil sorunlarının ve maddi sorunların geldiği görülmüştür. Katılımcıların, okulun mülteci öğrencilere Türkçelerini geliştirmek, dil öğrenmek, sosyalleşmeleri açısından uygun ortam sunmak yönünde katkı sağladığını düşündükleri belirlenmiştir. Öte yandan katılımcıların, çocukların okula kayıt yaptırdığı halde okula uyumunun yeterince sağlanamadığını, çocuklara sunulan psiko-sosyal desteğin yetersiz olduğunu, büyük çocukların okula devam etmek istemediklerini, eğitim yardımı aldıkları için zorunluluktan dolayı okula devam etiklerini, çocukların yaşadığı travmayı gidermeye yönelik psiko-sosyal destek verilmesi gerektiğini, eğitimlerinde dil probleminin olduğunu ve bu durumun çözüme kavuşturulması gerektiğini ifade ettikleri belirlenmiştir.
The spread of multilingualism in higher education and its repercussions for language for specific purposes
Authors: Lasagabaster David
Published: June 2023

At a time when multilingualism is spreading across university contexts all over the world, this article focuses on the major repercussions that the coexistence of different languages has on Languages for Specific Purposes (LSP). After analysing the interface between LSP and multilingualism, the University of the Basque Country UPV/EHU is put forward as a very good case in point of how multilingual universities are endeavouring to face the many challenges that the multilingual turn entails. The article underscores the need to foster collaboration not only between content and LSP specialists, but also between LSP practitioners in different languages.
Nanopore amplicon sequencing with DIY adapter v1
Authors: Hao Ou Jie
Published: June 2023

Nanopore amplicon sequencing with DIY adapter
Clinical metagenomic sequencing - CSF RNA and DNA Illumina MiSeq v1
Authors: Marais Gert
Published: June 2023

This protocol was developed to evaluate unbiased cerebrospinal fluid metagenomics at a referral centre in South Africa. Commercial kit protocols are generally used unmodified and limited use of in-house developed methods or reagents is made. This maintains the simplicity and accessibility of the protocol which can serve as a base for evaluation of process improvements.
Co-immunoprecipitation protocol to study LRRK2 binding to Rab12 in a cell-based assay v1
Authors: Tonelli Francesca
Published: June 2023

This protocol describes the immunoprecipitation (IP) of FLAG-tagged LRRK2 from whole cell lysates to assess its interaction with Rab12. This method can be used to screen the impact that LRRK2 mutations have on its binding to Rab12 in cells, as well as the effect of any compound or cell treatment on LRRK2 interaction with Rab12. Note: The IP products can be analysed by quantitative immunoblotting (as described in dx.doi.org/10.17504/protocols.io.bsgrnbv6) using an antibody targeting Rab12.
PEMBINAAN KEMAMPUAN PROFESIONAL GURU SEKOLAH DASAR (Studi Kualitatif Tentang Pembinaan Kemampuan Profesional Guru Sekolah Dasar di Kecamatan Bekasi Selatan Kota Bekasi)
Authors: Nugrawati N. R. Ema
Published: June 2023

Profesionalisme tenaga pendidik sangat berhubungan erat dengan mutu pendidikan, sebab proses belajar sebagai inti dari pendidikan akan sangat tergantung pada tenaga pendidik yang professional dan kualitas hasil belajar merupakan ujung tombak kualitas pendidikan. Dengan anggapan semacam itu, maka keberadaan tenaga pendidik atau guru yang profesional semakin penting, dan peranan siswa dalam belajar merupakan tumpuan upaya peningkatan kualitas pendidikan sesuai standar nasional pendidikan. Pasal 35 UU Nomor 20 Tahun 2003 tentang Sistem Pendidikan Nasional mengamanatkan agar “Pendidikan memiliki Standar Nasional Pendidikan (SNP), sebagai acuan pengembangan dan pengendalian pendidikan”. Dan pada Peraturan Pemerintah Nomor 19 Tahun 2005 Bab II Pasal 2 menyebutkan “standar nasional pendidikan mencakup standar isi, proses, kompetensi lulusan, tenaga kependidikan, sarana- prasarana, pengelolaan, pembiayaan, dan penilaian pendidikan”.Setelah melakukan observasi di lapangan ditemukan adanya indikasi latar belakang pendidikan guru yang bervariasi dari berbagai lulusan perguruan tinggi bahkan terdapat latar belakang pendidikan guru dari lulusan SMA atau sederajat. Berdasarkan temuan ini, maka untuk meningkatkan kemampuan profesional Guru SD diperlukan adanya kegiatan pembinaan terutama di kecamatan Bekasi Selatan.
KONTRIBUSI KINERJA KOMITE SEKOLAH DAN KEPEMIMPINAN KEPALA SEKOLAH TERHADAP PENINGKATAN MUTU PEMBELAJARAN DI SEKOLAH
Authors: Karman Ojo
Published: June 2023

Pembangunan pendidikan merupakan salah satu investasi sumber daya manusia (SDM) yang dapat memacu daya saing pada era globalisasi. Pengembangan kualitas SDM melalui pendidikan merupakan investasi produktif untuk meningkatkan daya saing bangsa dan produktivitas bangsa dalam beibagai sedor pembangunan. Fokus permasalahan dalam penelitian ini adalah bagaimana kontribusi kinerja komite sekolah dan kepemiminan kepala sekolah terhadap peningkatan mutu pembelajaran di sekolah. Peningkatan mutu pembelajaran di sekolah merupakan ujung tombak pembangunan pendidikan nasional yang diarahkan untuk memenuhi kebutuhan pengguna layanan pendidikan. Dalam hal ini sangat penting dipahami bersama bahwa kinerja komite sekolah yang baik akan sangat ditentukan oleh seberapa harmonis dalam melakukan kerjasama kemitraan dengan kepala sekolah sebagai pelaksana pendidikan, yang secara langsung mengelola di sekolah
PENGARUH KEPEMIMPINAN SITUASIONAL KEPALA SEKOLAH DAN DISIPLIN KERJA TERHADAP ETOS KERJA GURU DI SMPN KECAMATAN CIBATU KABUPATEN PURWAKARTA
Authors: Dewi Vitha Prima
Published: June 2023

Penelitian ini bertujuan untuk menganalisis Pengaruh kepemimpinan Situasional kepala sekolah dan Disiplin Kerja Terhadap Etos Keija Guru di SMPN Kecamatan Cibatu Kabupaten Purwakarta. Populasi dalam penelitian ini adalah guru di SMPN Kecamatan Cibatu Kabupaten Purwakarta yakni 46 orang. Dari populasi guru akan diambil secara keseluruhan sebagai sampel sebagaimana yang dikemukakan Arikunto (1998:107) “Untuk sekedar ancer-ancer maka apabila subyeknya kurang dari 100, maka lebih baik diambil semua, sehingga penelitian merupakan penelitian populasi”. Teknik analisis yang digunakan adalah analisis regresi. Hasil penelitian mengindikasikan: (1) terdapat pengaruh kepemimpinan situasional kepala sekolah terhadap etos kerja guru di SMPN Kecamatan Cibatu Kabupaten Purwakarta, (2) terdapk pengaruh disiplin kerja guru terhadap etos keija guru di SMPN Kecamatan Cibatu Kabupaten Purwakarta, (3) terdapat pengaruh kepemimpinan situasional kepala sekolah terhadap disiplin kerja guru di SMPN Kecamatan Cibatu Kabupaten Purwakarta
KONTRIBUSI MOTIVASI KERJA DAN IKLIM SEKOLAH TERHADAP KINERJA MANAJERIAL KEPALA SEKOLAH
Authors: Sujani Dede Irfan
Published: June 2023

Abstrak Kepala sekolah merupakan seorang manajer yang menjadi sumber daya manusia penting dalam menentukan mutu pendidikan. Kinerja manajerial kepala sekolah yang baik merupakan salah satu indikator pendidikan yang bermutu. Kinerja manajerial kepala sekolah perlu ditopang oleh motivasi kerja kepala sekolah dan iklim sekolah. Penelitian ini bertujuan untuk memperoleh deskripsi empirik kontribusi motivasi kerja kepala sekolah dan iklim sekolah baik secara parsial maupun secara simultan terhadap kinerja manajerial kepala sekolah. Metode yang digunakan dalam penelitian ini adalah metode survey deskripsi analisis dengan pendekatan kuantitatif melalui regresi korelasi sederhana dan berganda. Hasil penelitian menunjukan bahwa motivasi kerja kepala sekolah berkontribusi cukup kuat terhadap kinerja manajerial kepala sekolah; iklim sekolah berkontribusi cukup kuat terhadap kinerja manajerial kepala sekolah; motivasi kerja kepala sekolah dan iklim sekolah secara simultan  berkontribusi kuat terhadap kinerja manajerial kepala sekolah.Abstrack The school principal is a manager of human resources that become important in determining the quality of education. Principals managerial performance is one indicator of good quality education. Managerial performance principals need to be supported by the principal motivation to work and school climate. This study aims to obtain empirical contribution of motivation job description principals and school climate either partially or simultaneously to the principal managerial performance. The method used in this study is a description of the survey method of analysis with a quantitative approach through simple correlation and multiple regression. The results showed that the principal motivation of the work is strong enough to contribute to the performance of managerial principals; school climate is strong enough to contribute to the performance of managerial principals; work motivation principals and school climate simultaneously contributing strongly to the principal managerial performance.
PENGARUH SUPERVISI KEPALA SEKOLAH DAN MOTIVASI BERPRESTASI GURU TERHADAP KINERJA MENGAJAR GURU
Authors: Rismawan Edi
Published: June 2023

Abstrak Tujuan penelitian ini adalah untuk mengetahui (1) gambaran Supervisi Kepala Sekolah (2) gambaran Motivasi Berprestasi Guru; (3) gambaran Kinerja Mengajar Guru;(4) pengaruh Supervisi Kepala Sekolah terhadap Motivasi Berprestasi Guru, (5) pengaruh Motivasi Berprestasi Guru terhadap Kinerja Mengajar Guru, (6) pengaruh Supervisi Kepala Sekolah terhadap Kinerja Mengajar Guru, (7) Pengaruh Supervisi Kepala Sekolah dan Motivasi Berprestasi Guru terhadap Kinerja Mengajar Guru. Hasil penelitian menunjukkan bahwa (1) Supervisi Kepala Sekolah berada pada kategori baik, (2) Motivasi Berprestasi Guru berada pada kategori baik, (3) Kinerja Mengajar Guru berada pada kategori baik,(4) Supervisi Kepala Sekolah (X) berpengaruh positif terhadap Motivasi Berprestasi Guru (Y1), (5) Motivasi Berprestasi Guru (Y1) berpengaruh positif terhadap Kinerja Mengajar Guru (Y2), (6) Supervisi Kepala Sekolah (X) berpengaruh positif terhadap Kinerja Mengajar Guru (Y2), (7) Supervisi Kepala Sekolah (X) dan Motivasi Berprestasi Guru (Y1) secara bersama-sama berpengaruh positif terhadap Kinerja Mengajar Guru (Y2). Abstract The purpose of this study was to determine (1) description of the Principal Supervision (2) description of the Achievement Motivation of Teachers; (3) description of Teachers' Teaching Performance, (4) the effect of the Principal Supervision of the Teacher Achievement Motivation, (5) the effect of Achievement Motivation on the Performance of Teachers Teaching Teachers, (6) the effect of the Principal Supervision of the Teacher's Teaching Performance, (7) effect of Supervising Principal and Achievement Motivation of Teachers to Teaching Performance of Teachers. The results showed that (1) Supervising Principal are in the good category, (2) Achievement Motivation of Teachers are in the good category, (3) Teaching Performance of Teachers are in the good category, (4) Supervising Principal (X) positive effect on Achievement Motivation Teacher (Y1), (5) Teacher Achievement Motivation (Y1) positive effect on the Performance of Teaching Teachers (Y2), (6) Supervising Principal (X) positive effect on the Performance of Teaching Teachers (Y2), (7) Supervising Principal (X) and Achievement Motivation Teacher (Y1) is jointly positive effect on the Performance of Teaching Teachers (Y2).
KOMPENSASI, MOTIVASI BERPRESTASI DAN KINERJA MENGAJAR GURU SMP DI YALA THAILAND SELATAN
Authors: Samaeng Arudee , Sutarsih Cicih
Published: June 2023

AbstrakTujuan penelitian ini adalah untuk mengetahui seberapa besar pengaruh kompensasi dan motivasi berprestasi terhadap kinerja mengajar guru pada SMP Tham Vitya di Provinsi Yala Thailand Selatan. Penelitian ini menggunakan metode survei dengan pendekatan kuantitatif. Alat pengumpulan data yang digunakan adalah kuesioner (angket). Hasil penelitian menunjukkan: (1) Ada pengaruh kompensasi terhadap kinerja mengajar guru pada SMP Tham Vitya di Provinsi Yala Thailand Selatan dengan criteria tinggi. (2) Ada pengaruh motivasi berprestasi terhadap kinerja mengajar guru pada SMP Tham Vitya di Provinsi Yala Thailand Selatan dengan criteria sangat tinggi. (3) Pengaruh kompensasi dan motivasi berprestasi secara simultan terhadap kinerja mengajar guru pada SMP Tham Vitya di Provinsi Yala Thailand Selatan dengan kriteria sangat tinggi, sedangkan sisanya dipengaruhi oleh faktor lain yang tidak dikaji dalam penelitian ini. Kinerja mengajar guru yang profesional perlu diperhatikan adalah aspek perencanaan, pelaksanaan, evaluasi, serta perbaikan dan pengayaan pembelajaran secara efektivitas dan seefisien mungkin, untuk memperbaiki dan meningkatkan kinerja mengajar guru, perlu optimalisasi kompensasi guru yang efektif dan motivasi berprestasi guru yang tinggi.Kata Kunci: Kompensasi, Motivasi Berprestasi, Kinerja Mengajar Guru. AbstractThe purpose of this study was to determine how much influence the compensation and achievement motivation on the performance of teachers teaching at Junior Hight School Tham Vitya in South Thailand Yala Province. This study used a survey method with quantitative approach. Data collection tool used was a questionnaire (questionnaire). The results showed: (1) There is an effect of compensation to the performance of teachers teaching at Junior Hight School Tham Vitya in South Thailand Yala province with high criteria. (2) There is the influence of achievement motivation on the performance of teachers teaching at Junior Hight School Tham Vitya in South Thailand Yala province with very high criteria. (3) Effect of compensation and achievement motivation simultaneously on the performance of teachers teaching at Junior Hight School Tham Vitya in South Thailand Yala province with very high criteria, while the rest influenced by other factors not examined in this study. Performance professional teachers teach to note is the aspect of planning, implementation, evaluation, and improvement and enrichment learning effectiveness and as efficiently as possible, to improve and enhance the teaching performance of teachers, need to optimize effective teacher compensation and teacher achievement motivation high. Keywords: Compensation, Achievement Motivation, Teachers' Teaching Performance.
Peningkatan Kemampuan Kepala Sekolah dalam menyusun Rencana Kerja Sekolah melalui Pendampingan Manajerial secara Kolaboratif di SMA Binaan Kota Batu
Authors: Setiyaningwati Titi
Published: June 2023

Abstrak:                    Penelitian ini bertujuan untuk meningkatkan kemampuan  Sekolah dalam menyusun Rencana Kerja  Sekolah ( RKS ) melalui Pendampingan Manajerial secara Kolaboratif di Sekolah binaan yaitu di SMA  Kota Batu. Penelitian ini tergolong Penelitian Tindakan  Sekolah   dengan   melibatkan 7 ( Tujuh ) orang Kepala Sekolah dimana 5 Kepala Sekolah belum  mampu menyusun RKS secara maksimal. Penelitian dilakukan dengan dua siklus, setiap siklus terdiri atas empat tahapan yaitu : Perencanaan , Pelaksanaan, Obervasi dan Refleksi. Hasil penelitian menunjukkan bahwa melalui Pendampingan Manajerial secara Kolaboratif dapat meningkatkan kemampuan Kepala  Sekolah dalam menyusun Rencana Kerja  Sekolah (RKS )  sesuai dengan kriteria yang ditentukan. Berdasarkan hasil analisis pada masing masing siklus menunjukkan peningkatan kemampuan Kepala Sekolah dalam menyusun RKS yakni : adanya peningkatan kinerja Kepala  Sekolah sehingga mampu menyusun Rencana Kerja  Sekolah ( RKS ) dari Siklus I sebesar 74,70 menjadi 81,37. Kata Kunci : Kemampuan Kepala  Sekolah, Rencana Kerja Sekolah, Manajerial Kolaboratif Abstract: This study aims to improve the ability of schools in preparing the Work Plan School (RKS) through Mentoring Collaborative School Managerial be built that is in high school in Batu. This study classified Schools Action Research involving 7 (Seven) the Principal of which 5 Principal has not been able to prepare optimally RKS. The study was conducted in two cycles, each cycle consisting of four phases, namely: Planning, Implementation, observation and Reflection. The results showed that through Mentoring Collaborative Managerial be able to improve the Principal in preparing the Work Plan School (RKS) in accordance with the prescribed criteria. Based on the analysis in each cycle show an increase in the ability of the principal in formulating RKS namely: an increase in performance Principal so as to prepare a Work Plan School (RKS) of the first cycle was 74.70 into 81.37. Keywords: Ability Principal in preparing, School Plan, Managerial Assistance in Collaborative