bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating conversational dynamics in triads: Effects of noise, hearing impairment, and hearing aids
Authors: Petersen Eline Borch
Published: April 2024

Communication is an important part of everyday life and requires a rapid and coordinated interplay between interlocutors to ensure a successful conversation. Here, we investigate whether increased communication difficulty caused by additional background noise, hearing impairment, and not providing adequate hearing-aid (HA) processing affected the dynamics of a group conversation between one hearing-impaired (HI) and two normal-hearing (NH) interlocutors. Free conversations were recorded from 25 triads communicating at low (50 dBC SPL) or high (75 dBC SPL) levels of canteen noise. In conversations at low noise levels, the HI interlocutor was either unaided or aided. In conversations at high noise levels, the HI interlocutor either experienced omnidirectional or directional sound processing. Results showed that HI interlocutors generally spoke more and initiated their turn faster, but with more variability, than the NH interlocutors. Increasing the noise level resulted in generally higher speech levels, but more so for the NH than for the HI interlocutors. Higher background noise also affected the HI interlocutors’ ability to speak in longer turns. When the HI interlocutors were unaided at low noise levels, both HI and NH interlocutors spoke louder, while receiving directional sound processing at high levels of noise only reduced the speech level of the HI interlocutor. In conclusion, noise, hearing impairment, and hearing-aid processing mainly affected speech levels, while the remaining measures of conversational dynamics (FTO median, FTO IQR, turn duration, and speaking time) were unaffected. Hence, although experiencing large changes in communication difficulty, the conversational dynamics of the free triadic conversations remain relatively stable.
How social background and interest in science are linked to junior high school students’ perceptions of the ecological transition
Authors: Nadarajah Kévin , Somat Alain , Baeyens Céline , Pansu Pascal
Published: April 2024

Junior high school students are tomorrow’s key protagonists in the ecological transition. They need enlightened education to face the uncertainty and challenges of climate change. The development of climate change education programs requires a clear understanding of how young people perceive the issue. This study deals with social representations. Its aim was to understand how social background and interest in science are linked to the way young people perceive the concept of the ecological transition. Four hundred twenty-nine junior high school students took part in this study. Data were collected and subjected to prototypical analysis and factorial correspondence analysis. Three main findings emerged from the analysis: (1) the participants had significant knowledge of the ecological transition, (2) their awareness of the social aspects of climate change was limited, and (3) their representations of the ecological transition were linked to their interest in science and their parents’ social background. To conclude, these results underline the importance of educating all social classes about effective solutions for the ecological transition. Our findings also highlight the need to consider existing representations and prior knowledge when designing educational programs on climate change issues.
Wildfires and social media discourse: exploring mental health and emotional wellbeing through Twitter
Authors: García Yury E. , Villa-Pérez Miryam Elizabeth , Li Kuang , Tai Xiao Hui , Trejo Luis A. , Daza-Torres Maria L. , Montesinos-López J. Cricelio , Nuño Miriam
Published: April 2024

Introduction

The rise in global temperatures due to climate change has escalated the frequency and intensity of wildfires worldwide. Beyond their direct impact on physical health, these wildfires can significantly impact mental health. Conventional mental health studies predominantly rely on surveys, often constrained by limited sample sizes, high costs, and time constraints. As a result, there is an increasing interest in accessing social media data to study the effects of wildfires on mental health.

Methods

In this study, we focused on Twitter users affected by the California Tubbs Fire in 2017 to extract data signals related to emotional well-being and mental health. Our analysis aimed to investigate tweets posted during the Tubbs Fire disaster to gain deeper insights into their impact on individuals. Data were collected from October 8 to October 31, 2017, encompassing the peak activity period. Various analytical methods were employed to explore word usage, sentiment, temporal patterns of word occurrence, and emerging topics associated with the unfolding crisis.

Results

The findings show increased user engagement on wildfire-related Tweets, particularly during nighttime and early morning, especially at the onset of wildfire incidents. Subsequent exploration of emotional categories using Linguistic Inquiry and Word Count (LIWC) revealed a substantial presence of negative emotions at 43.0%, juxtaposed with simultaneous positivity in 23.1% of tweets. This dual emotional expression suggests a nuanced and complex landscape, unveiling concerns and community support within conversations. Stress concerns were notably expressed in 36.3% of the tweets. The main discussion topics were air quality, emotional exhaustion, and criticism of the president's response to the wildfire emergency.

Discussion

Social media data, particularly the data collected from Twitter during wildfires, provides an opportunity to evaluate the psychological impact on affected communities immediately. This data can be used by public health authorities to launch targeted media campaigns in areas and hours where users are more active. Such campaigns can raise awareness about mental health during disasters and connect individuals with relevant resources. The effectiveness of these campaigns can be enhanced by tailoring outreach efforts based on prevalent issues highlighted by users. This ensures that individuals receive prompt support and mitigates the psychological impacts of wildfire disasters.
Dry sliding wear and friction performance of zirconium dioxide tribopairs
Authors: Bailey Richard , Sun Yong
Published: April 2024

Zirconium is an attractive engineering material owing to its commendable temperature, corrosion resistance, and excellent biocompatibility. Despite these merits, its industrial applicability is hindered by elevated wear and friction in tribological settings. Previous research has concentrated on unmatched pair contacts involving zirconium and alumina primarily due to the exceptional hardness. However, there is a noticeable dearth of literature on the matched pair contact condition for zirconium dioxide. Thermal oxidation is a promising and cost-effective method to address the suboptimal tribological performance and enhance the mechanical and electrochemical properties of zirconium. In this study, thermal oxidation is employed to produce a 6-μm-thick oxide layer in an air furnace at 650°C for 6 h. Subsequently, the resulting surface coating was tribologically tested using a pin-on-disc tribometer against two distinct counterface materials, namely, alumina and zirconium dioxide, in a dry and unlubricated environment. The findings reveal that matched contact between the zirconium dioxide tribopair is unfavorable, leading to elevated friction and wear rates. Consequently, this configuration should be avoided in dry contact situations characterized by high contact pressures. However, under lower contact pressures, the wear performance is acceptable. Furthermore, when combined with lubrication, this system may have potential applications in bio-tribological systems.
Outline of an evolutionary morphology generator towards the modular design of a biohybrid catheter
Authors: Tsompanas Michail-Antisthenis , Balaz Igor
Published: April 2024

Biohybrid machines (BHMs) are an amalgam of actuators composed of living cells with synthetic materials. They are engineered in order to improve autonomy, adaptability and energy efficiency beyond what conventional robots can offer. However, designing these machines is no trivial task for humans, provided the field’s short history and, thus, the limited experience and expertise on designing and controlling similar entities, such as soft robots. To unveil the advantages of BHMs, we propose to overcome the hindrances of their design process by developing a modular modeling and simulation framework for the digital design of BHMs that incorporates Artificial Intelligence powered algorithms. Here, we present the initial workings of the first module in an exemplar framework, namely, an evolutionary morphology generator. As proof-of-principle for this project, we use the scenario of developing a biohybrid catheter as a medical device capable of arriving to hard-to-reach regions of the human body to release drugs. We study the automatically generated morphology of actuators that will enable the functionality of that catheter. The primary results presented here enforced the update of the methodology used, in order to better depict the problem under study, while also provided insights for the future versions of the software module.
Measuring the impact of dental service quality on revisit intention using an extended SERVQUAL model
Authors: Sharka Rayan , Sedayo Lamer , Morad Majd , Abuljadayel Jameel
Published: April 2024

Background

The pursuit of quality services can lead to both service enhancement and increased motivation to visit dental centers for oral health treatment.

Aims

The purpose of this study is to investigate the effect of dental center service quality factors on revisit intention among adult patients by applying an extended service quality model (SERVQUAL).

Methods

This cross-sectional study was conducted between September and November 2023 in the outpatient waiting areas and clinical settings of Umm Al-Qura University Dental Teaching Hospital (UQU-DTH). A sample of 355 patients was invited by the convenience sampling method. The data was collected through a validated Arabic version of the extended SERVQUAL questionnaire. A hierarchical regression analysis was used to assess the incremental effects of the extended SERVQUAL factors on the intention of patients to revisit the UQU-DTH while controlling for demographic variables. Cronbach alpha was used to examine the internal consistency of each model factor.

Results

A total of 330 completed responses were received, with a 93% response rate. The findings indicated that demographic variables such as age and level of education contribute to some extent but become negligible when the extended SERVQUAL factors are included in the model. Moreover, the extended SERVQUAL model factors substantially improved the model. Three factors were found to positively and significantly affect the revisit intention, namely, “staff-related factors,” “cost-effectiveness,” and “responsiveness.” Overall, the model explained 65.6% of the variance in the revisit intention (R2 = 0.656, p < 0.001).

Conclusion

The findings present a unique model that may be used to better understand the factors that influence patients' intentions to revisit dental centers in an educational setting. Additionally, it identified elements that dental center quality management needs to prioritize and address.
Assessing the individual relationships between physical test improvements and external load match parameters in male professional football players—a brief report
Authors: Byrkjedal Per Thomas , Bjørnsen Thomas , Luteberget Live Steinnes , Ivarsson Andreas , Spencer Matt
Published: April 2024

Purpose

This study aimed to explore whether a meaningful improvement in physical performance following an in-season strength training intervention can be related to external load match parameters at an individual level in professional male football players.

Methods

Eight male professional football players (25.4 ± 3.1 years, 184.1 ± 3.4 cm, 79.3 ± 2.2 kg) completed a 10-week strength intervention period in addition to football-specific training and matches. Commonly used physical and external load measures were assessed before and after intervention. Physical performance improvements had to exceed the measurement’s typical error and the smallest worthwhile difference (SWD) to be considered meaningful. External load match parameters were assessed before and after the intervention period using SWD and non-overlap of all pairs (NAP) analysis. A Bayesian pairwise correlation analysis was performed to evaluate relationships between changes in physical performance and external load match parameters.

Results

Three players displayed meaningful improvements in two to five physical performance measures. However, positive changes exceeding the SWD and positive effects in NAP results were observed for all players in external load match parameters. Kendall's tau correlation analysis showed evidence (base factor >3) for only one correlation (maximum speed − decelerations, τ = −0.62) between the changes in physical performance and external load measures, while the remaining comparisons exhibited no relation.

Conclusions

The findings suggest that improvements in physical performance may not necessarily translate to improvements in external load match parameters. Further research, with larger sample sizes, is needed to understand potential mechanisms between acute and chronic physical performance changes and football external load parameters during training and matches.
Sleeve resection with end-to-end anastomosis in the reconstruction of tracheal defects exceeding six rings: a clinical feasibility study and safety assessment
Authors: Xia Xin , Zhu Xiaoli , Zhu Yingying , Diao Wenwen , Chen Xingming
Published: April 2024

Objectives

Reconstruction is always required for tracheal defects and sleeve resection with end-to-end anastomosis is the most common used. The aim of the study was to present surgical techniques and evaluate the outcomes of sleeve resection with end-to-end anastomosis in the reconstruction of tracheal defects exceeding six rings.

Methods

The study included patients with primary or secondary malignancies and tracheal stenosis from 2014 to 2019, who were treated with sleeve resection exceeding six tracheal rings, and reconstructed with end-to-end anastomosis. Airway status and patient outcomes were the principal follow-up measures.

Results

A total of 16 patients were enrolled in the study including three primary tracheal malignancies, 12 invasive thyroid carcinomas and one with tracheal stenosis. The extent of tracheal resection ranged from seven to nine rings, and the primary end-to-end anastomosis was performed in all 16 patients. Performance of tracheostomy or cricothyroidotomy was done in 6 patients with decannulation at a median of 42 days (range, 28–56). No anastomotic dehiscence, infection or bleeding occurred postoperatively, and all 16 patients maintained an unobstructed airway through the end of follow-up.

Conclusions

Sleeve resection reconstructed with end-to-end anastomosis can serve as an appropriate therapeutic strategy for the tracheal defects even exceeding six rings. Adequate laryngeal release is the key to surgical success.
Pony feeding management: the role of morphology and hay feeding methods on intake rate, ingestive behaviors and mouth shaping
Authors: Bordin Clara , Raspa Federica , Greppi Martina , Harris Patricia , Ellis Andrea Dorothea , Roggero Angela , Palestrini Claudia , Cavallini Damiano , Bergero Domenico , Valle Emanuela
Published: April 2024

In the last decade, haynets and slow feeders have been promoted as sustainable tools to improve the feeding management of horses and reduce forage waste, but little is known about their effects on ponies. Therefore, the aim of this study was to analyze the effects of different hay feeding methods on the ingestive behaviors, intake rate and mouth shaping of ponies belonging to two breed types, which are characterized by different head morphologies. Shetland type (SH, n = 5) and Welsh/Cob type (WC, n = 4) ponies were fed hay using four feeding methods: on the ground (G), a fully filled haynet (HF), a partially filled haynet (HL), and a slow-feeder hay box (HB). Head morphology was measured for each pony. Video recordings were then made to apply geometric morphometrics and to perform behavioral analysis. The intake rate was measured for each pony and each feeding method. Data obtained with geometric morphometrics were analyzed using principal component analysis (PCA) and canonical variate analysis (CVA). Behavioral data and intake rate measurements were analyzed using a mixed model, a post-hoc Tukey’s test, a Pearson’s correlation test, and a stepwise regression model. The geometric morphometrics results demonstrated that feeding method influenced mouth shaping (36% for G, 78% for HB, 77% for HF, 83% for HL, considering the total variance of shape) and affected the intake rate. Differences in mouth shaping and ingestive behaviors in SH and WC ponies also confirmed the role of morphology in feeding management. The HL proved to be the most effective tool to increase feeding consumption time when needed (5 h/kg for SH ponies and 3 h/kg for WC ponies, considering the intake time), although the HB may be the optimal choice to reduce the intake rate while maintaining a more natural posture. Future studies are suggested to fully understand how body size and morphology influence feeding in equine species.
A randomized trial to compare smooth monofilament suture vs. barbed suture using the three-layer continuous closure technique in canine ovariohysterectomy in a high-quality high-volume spay/neuter clinic
Authors: Shivley Jacob M. , Brookshire W. Cooper , Shealy Alex P. , Seyer Chase A. , Bushby Philip A. , Woodruff Kimberly A.
Published: April 2024

The primary objective of this study was to compare time efficiency and complication rates between smooth monofilament suture (SMS) and barbed suture (BS) using the three-layer continuous incisional closure pattern after ovariohysterectomy in a high-quality high-volume spay/neuter clinic. The study was designed as a randomized controlled trial enrolling 71 adult female dogs. Dogs were randomly assigned to SMS or BS treatments. The effect of closure with BS or SMS on closure time was tested through multilevel, multivariable linear regression in a generalized linear mixed model. Body condition score, weight, and pre-closure incision length were tested as covariates. Surgeon was included in the model as a random effect. Pre-closure incision length (p = 0.01) and method (p ≤ 0.0001) were associated with closure time. Adjusting for pre-closure incision length, the average time for closure with SMS was 6.5 min (range 3.70–10.31 min), and the average time for closure with BS was 4.91 min (range 3.05–8.05 min). Accounting for the closure method, the closure time increased by 39 s for each additional centimeter of incision length. BS was more efficient than SMS when performing the three-layer continuous suture pattern. No short-term telemedicine-assessed complications were noted with either treatment method. BS can improve efficiency in surgical closures, especially considering large volumes of animals, and appears to have a similar short-term, telemedicine-assessed complication rate when compared to SMS.
Whole-genome analysis of the recombination and evolution of newly identified NADC30-like porcine reproductive and respiratory syndrome virus strains circulated in Gansu province of China in 2023
Authors: Jiao Shoude , Zhang Jing , Wang Jian , Ma Xueqing , Li Guoxiu , Li Jiaoyang , Cui Zhanding , Li Dong , Li Pinghua , Zeng Qiaoying , Liu Zaixin , Lu Zengjun , Sun Pu
Published: April 2024

Porcine reproductive and respiratory syndrome virus (PRRSV) remains one of the major threats to swine industry, resulting in huge economic losses worldwide. Currently, PRRSV has diversified into multiple lineages with characteristics of extensive recombination in China. In this research, three virus strains were isolated and four virus whole genome sequences were generated and analyzed from clinical samples collected in Gansu province of China in 2023. The four virus strains were designated GSTS4-2023, GSLX2-2023, GSFEI2-2023 and GSBY4-2023. Phylogenetic analysis based on ORF5 sequences showed that GSTS4-2023, GSLX2-2023, GSFEI2-2023 and GSBY4-2023 shared 91.7, 91.2, 93.2 and 92.9% homology with NADC30 strain respectively, and belonged to lineage 1 of PRRSV-2. In addition, one amino acid deletion was observed at position 33 in ORF5 of GSTS4-2023, GSLX2-2023 and GSFEI2-2023. Moreover, amino acid alignment of the four strains showed a typical discontinuous 131-amino acid (aa) deletion in NSP2 for NADC30-like virus strains. Recombination analysis revealed that all four strains originated from NADC30 (lineage 1), with their minor parents coming from JXA1-like strains (lineage 8), VR-2332-like strains (lineage5) and QYYZ-like strains (lineage3). Finally, the three isolated virus strains, GSTS4-2023, GSLX2-2023 and GSFEI2-2023 showed relatively low levels of replication in cell culture. Our findings provide important implications for the field epidemiology of PRRSV.
Collaborative Localization Method Based on Hybrid Network for Aerial Swarm
Authors: Wang Rong , Zhang Huiyuan , Gu Chen , Xiong Zhi , Liu Jianye
Published: April 2024

In light of the satellite rejection environment and how aircraft can obtain high-precision positioning, this paper proposes a collaborative correction algorithm for aircraft based on the rank-defect network. Aiming at the problem of insufficient anchor points, which result in insufficient observations and the divergence of aircraft inertial navigation errors, this algorithm can effectively improve the navigation performance of cluster aircraft. On the basis of the observation information provided by the anchor aircraft, the observation information between aircraft is fully utilized to improve the observability of the aircraft cluster positioning method. At the same time, the pseudo-observation equation of heterogeneous aircraft cluster positioning is introduced, and the divergence of inertial navigation positioning errors caused by insufficient observations is suppressed by the pseudo-observation solution. On the basis of introducing the pseudo-observation equation, the inertial navigation error is solved and corrected by the Newton iterative method and the divergence of the inertial navigation position error is restrained. Compared with an aircraft cluster positioning method that does not use the inertial navigation error co-correction based on the pseudo-observation solution, this paper can achieve better overall cluster positioning accuracy when the available observations are insufficient, which is suitable for practical applications.
Nrf2 Plays a Key Role in Erythropoiesis during Aging
Authors: Mbiandjeu Serge Cedrick Toya , Siciliano Angela , Mattè Alessandro , Federti Enrica , Perduca Massimiliano , Melisi Davide , Andolfo Immacolata , Amoresano Angela , Iolascon Achille , Valenti Maria Teresa , Turrini Francesco , Bovi Michele , Pisani Arianna , Recchiuti Antonio , Mattoscio Domenico , Riccardi Veronica , Dalle Carbonare Luca , Brugnara Carlo , Mohandas Narla , De Franceschi Lucia
Published: April 2024

Aging is characterized by increased oxidation and reduced efficiency of cytoprotective mechanisms. Nuclear factor erythroid-2-related factor (Nrf2) is a key transcription factor, controlling the expression of multiple antioxidant proteins. Here, we show that Nrf2−/− mice displayed an age-dependent anemia, due to the combined contributions of reduced red cell lifespan and ineffective erythropoiesis, suggesting a role of Nrf2 in erythroid biology during aging. Mechanistically, we found that the expression of antioxidants during aging is mediated by activation of Nrf2 function by peroxiredoxin-2. The absence of Nrf2 resulted in persistent oxidation and overactivation of adaptive systems such as the unfolded protein response (UPR) system and autophagy in Nrf2−/− mouse erythroblasts. As Nrf2 is involved in the expression of autophagy-related proteins such as autophagy-related protein (Atg) 4-5 and p62, we found impairment of late phase of autophagy in Nrf2−/− mouse erythroblasts. The overactivation of the UPR system and impaired autophagy drove apoptosis of Nrf2−/− mouse erythroblasts via caspase-3 activation. As a proof of concept for the role of oxidation, we treated Nrf2−/− mice with astaxanthin, an antioxidant, in the form of poly (lactic-co-glycolic acid) (PLGA)-loaded nanoparticles (ATS-NPs) to improve its bioavailability. ATS-NPs ameliorated the age-dependent anemia and decreased ineffective erythropoiesis in Nrf2−/− mice. In summary, we propose that Nrf2 plays a key role in limiting age-related oxidation, ensuring erythroid maturation and growth during aging.
Acetic Fermentation of Cagaita Pulp: Technological and Chemical Characteristics
Authors: Santana Jeisa Farias De Sousa , Hercos Guilherme Freitas de Lima , Oliveira Filho Josemar Gonçalves de , Santos Daiane Costa dos , Oliveira Marilene Silva , Freitas Bheatriz Silva Morais de , Silva Fabiano Guimarães , Egea Mariana Buranelo
Published: April 2024

The Brazilian Cerrado region has a rich plant diversity, with fruits that have peculiar and unique sensory characteristics. For these reasons, using these fruits for biotechnological production is a promising alternative, mainly to protect this biome from deforestation and degradation. The production of fermented acetic acid is an option to add value to native fruits and offer the market beverages with better nutritional quality and bioactive compounds. This work aimed to characterize fruits and to develop cagaita (Eugenia dysenterica DC.) acetic fermented beverage. The fruits were subjected to physical-chemical analyses in the first part. Subsequently, different treatments for fermentation were tested using two types of enzymes (amylase and pectinase), two subspecies of Saccharomyces cerevisiae yeast (UFLA CA11 and thermoresistant LNF Angel), and the chaptalization of the must with sucrose (16 °Brix). Alcoholic fermentation was carried out in an incubator with temperature control at 34 ± 1 °C. The pH, total soluble solids, titratable acidity, alcohol content, and density of the fermented products were monitored daily. The chaptalized must with amylase addition and thermoresistant yeast had the best performance during alcoholic fermentation, demonstrating that thermoresistant yeast is an economically advantageous and efficient alternative for the cagaita juice fermentation process. Subsequently, acetic fermentation was carried out using the slow method. Heat-resistant yeast without added enzymes was used to produce cagaita acetic fermented beverages within the parameters of the Brazilian legislation. Furthermore, phenolic compounds and antioxidant activity in the final product were observed. The work demonstrated the possibility of using cagaita fruits in biotechnological processes to produce new food products.
Fetal Heart Rate Preprocessing Techniques: A Scoping Review
Authors: Campos Inês , Gonçalves Hernâni , Bernardes João , Castro Luísa
Published: April 2024

Monitoring fetal heart rate (FHR) through cardiotocography is crucial for the early diagnosis of fetal distress situations, necessitating prompt obstetrical intervention. However, FHR signals are often marred by various contaminants, making preprocessing techniques essential for accurate analysis. This scoping review, following PRISMA-ScR guidelines, describes the preprocessing methods in original research articles on human FHR (or beat-to-beat intervals) signal preprocessing from PubMed and Web of Science, published from their inception up to May 2021. From the 322 unique articles identified, 54 were included, from which prevalent preprocessing approaches were identified, primarily focusing on the detection and correction of poor signal quality events. Detection usually entailed analyzing deviations from neighboring samples, whereas correction often relied on interpolation techniques. It was also noted that there is a lack of consensus regarding the definition of missing samples, outliers, and artifacts. Trends indicate a surge in research interest in the decade 2011–2021. This review underscores the need for standardizing FHR signal preprocessing techniques to enhance diagnostic accuracy. Future work should focus on applying and evaluating these methods across FHR databases aiming to assess their effectiveness and propose improvements.
Towards Transparent Healthcare: Advancing Local Explanation Methods in Explainable Artificial Intelligence
Authors: Metta Carlo , Beretta Andrea , Pellungrini Roberto , Rinzivillo Salvatore , Giannotti Fosca
Published: April 2024

This paper focuses on the use of local Explainable Artificial Intelligence (XAI) methods, particularly the Local Rule-Based Explanations (LORE) technique, within healthcare and medical settings. It emphasizes the critical role of interpretability and transparency in AI systems for diagnosing diseases, predicting patient outcomes, and creating personalized treatment plans. While acknowledging the complexities and inherent trade-offs between interpretability and model performance, our work underscores the significance of local XAI methods in enhancing decision-making processes in healthcare. By providing granular, case-specific insights, local XAI methods like LORE enhance physicians’ and patients’ understanding of machine learning models and their outcome. Our paper reviews significant contributions to local XAI in healthcare, highlighting its potential to improve clinical decision making, ensure fairness, and comply with regulatory standards.
Novel Method for Sealing Tracheostomies Immediately after Decannulation—An Acute Clinical Feasibility Study
Authors: Kraghede Rasmus Ellerup , Christiansen Karen Juelsgaard , Kaspersen Alexander Emil , Pedersen Michael , Petersen Johanne Juel , Hasenkam John Michael , Devantier Louise
Published: April 2024

Tracheostomy decannulation leaves an iatrogenic passage in the upper airways. Inadequate sealing leads to pulmonary dysfunction and reduced voice quality. This study aimed to investigate the feasibility and impact of intratracheal tracheostomy sealing on laryngeal airflow and voice quality immediately after decannulation (ClinicalTrials.gov: NCT06138093). Fifteen adult, tracheostomized, intensive care unit patients were included from our hospital. A temporary, silicone-based sealing disc was inserted in the tracheostomy wound immediately after decannulation. Spirometry with measurement of forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and peak expiratory flow (PEF) were performed as measures of airway flow. Voice recordings were assessed using an equal appearing interval scale from 1 to 5. Median FVC, FEV1, PEF, and voice quality score with interquartile range (IQR) was 883 (510–1910) vs. 1260 (1005–1723) mL (p < 0.001), 790 (465–1255) vs. 870 (617–1297) mL (p < 0.001), 103 (55–211) vs. 107 (62–173) mL (p = 0.720), and 2 (1–2.5) vs. 4 (3–5) points (p < 0.001), respectively, with open tracheostomy vs. after sealing the tracheostomy with the intratracheal sealing disc. This feasibility study showed that tracheostomy sealing with the intratracheal disc was safe and led to immediate improvements in FVC, FEV1, and voice quality.
The Development of a Regulator of Human Serine Racemase for N-Methyl-D-aspartate Function
Authors: Lu Lu-Ping , Chang Wei-Hua , Mao Yi-Wen , Cheng Min-Chi , Zhuang Xiao-Yi , Kuo Chi-Sheng , Lai Yi-An , Shih Tsai-Miao , Chou Teh-Ying , Tsai Guochuan Emil
Published: April 2024

It is crucial to regulate N-methyl-D-aspartate (NMDA) function bivalently depending on the central nervous system (CNS) conditions. CNS disorders with NMDA hyperfunction are involved in the pathogenesis of neurotoxic and/or neurodegenerative disorders with elevated D-serine, one of the NMDA receptor co-agonists. On the contrary, NMDA-enhancing agents have been demonstrated to improve psychotic symptoms and cognition in CNS disorders with NMDA hypofunction. Serine racemase (SR), the enzyme regulating both D- and L-serine levels through both racemization (catalysis from L-serine to D-serine) and β-elimination (degradation of both D- and L-serine), emerges as a promising target for bidirectional regulation of NMDA function. In this study, we explored using dimethyl malonate (DMM), a pro-drug of the SR inhibitor malonate, to modulate NMDA activity in C57BL/6J male mice via intravenous administration. Unexpectedly, 400 mg/kg DMM significantly elevated, rather than decreased (as a racemization inhibitor), D-serine levels in the cerebral cortex and plasma. This outcome prompted us to investigate the regulatory effects of dodecagalloyl-α-D-xylose (α12G), a synthesized tannic acid analog, on SR activity. Our findings showed that α12G enhanced the racemization activity of human SR by about 8-fold. The simulated and fluorescent assay of binding affinity suggested a noncooperative binding close to the catalytic residues, Lys56 and Ser84. Moreover, α12G treatment can improve behaviors associated with major CNS disorders with NMDA hypofunction including hyperactivity, prepulse inhibition deficit, and memory impairment in animal models of positive symptoms and cognitive impairment of psychosis. In sum, our findings suggested α12G is a potential therapeutic for treating CNS disorders with NMDA hypofunction.
Frequency of MRI Low Signal Intensity in the Buccal Fat of Fetuses and Speculation as to What It May Reflect
Authors: Venkatakrishna Shyam Sunder B. , Takahashi Marcelo S. , Calle-Toro Juan S. , Schoeman Sean , Martin Saavedra Juan Sebastian , Alkhulaifat Dana , Serai Suraj D. , Andronikou Savvas
Published: April 2024

Purpose: We aimed to characterize the fetal buccal fat pad (BFP) on magnetic resonance imaging (MRI) to determine the frequency and types of sequences on which the BFP demonstrates low signal intensity and determine any possible correlation with timing of the MRI during fetal development. Materials and Methods: A retrospective review of all fetal MR studies was performed, and a pediatric radiologist blinded to the referring and final fetal diagnosis as well as outcome evaluated the included cases. A positive buccal fat pad sign (BFS) was recorded as present if a round, symmetric, and bilateral area was seen in the submalar region of the face with the following signal characteristics: T1 hyperintensity, low signal on echo planar imaging (EPI), low signal on true fast imaging with steady-state free precession (TRUFI), and with restriction on diffusion-weighted imaging (DWI). Results: A total of one hundred sixty-seven (167) fetal MRI studies: one hundred fourteen (114) body (68%) and fifty-three (53) neuro (32%) scans were reviewed during the study period. The BFS was most commonly seen on EPI (63%) and TRUFI (49%) sequences. Substantial agreement between TRUFI and EPI (κ = 0.68; p < 0.01); moderate agreement between TRUFI and T1 (κ = 0.53; p < 0.01) as well as T1 and EPI (κ = 0.53; p < 0.01), and fair agreement between EPI and Diffusion (κ = 0.28; p < 0.01) was observed. The median gestational age (GA) was 24 weeks (IQR 22–30 weeks). The fetuses with a positive BFS were significantly older (mean GA of 27 weeks or higher) than those without, for each sequence. Conclusions: The focal low signal in the fetal buccal fat pad, termed the fetal BFS, is a commonly encountered normal finding in the majority of fetal MRI scans on TRUFI and EPI sequences. This finding may be related to the presence and development of brown adipose tissue in the buccal fat pad resulting in T2* effects, but further studies are needed in order to confirm this. Further work can incorporate any of the sensitive sequences demonstrating low signal in brown adipose tissue to map its distribution and development in the fetus and beyond.
Air–Water Two-Phase Flow Dynamics Analysis in Complex U-Bend Systems through Numerical Modeling
Authors: Kükrer Ergin , Eskin Nurdil
Published: April 2024

This study aims to provide insights into the intricate interactions between gas and liquid phases within flow components, which are pivotal in various industrial sectors such as nuclear reactors, oil and gas pipelines, and thermal management systems. Employing the Eulerian–Eulerian approach, our computational model incorporates interphase relations, including drag and non-drag forces, to analyze phase distribution and velocities within a complex U-bend system. Comprising two horizontal-to-vertical bends and one vertical 180-degree elbow, the U-bend system’s behavior concerning bend geometry and airflow rates is scrutinized, highlighting their significant impact on multiphase flow dynamics. The study not only presents a detailed exposition of the numerical modeling techniques tailored for this complex geometry but also discusses the results obtained. Detailed analyses of local void fraction and phase velocities for each phase are provided. Furthermore, experimental validation enhances the reliability of our computational findings, with close agreement observed between computational and experimental results. Overall, the study underscores the efficacy of the Eulerian approach with interphase relations in capturing the complex behavior of the multiphase flow in U-bend systems, offering valuable insights for hydraulic system design and optimization in industrial applications.
Indium-Doped SnO2 Based Surface Acoustic Wave Gas Sensor with Ba0.6Sr0.4TiO3 Film
Authors: Alemayehu Birhanu , Annam Kaushik , Shin Eunsung , Subramanyam Guru
Published: April 2024

SnO2-based gas sensors have been widely synthesized and used for the detection of various hazardous gases. However, the use of doped SnO2 in sensing applications has recently attracted increased interest due to the formation of a synergistic effect between the dopant and the host. Moreover, in the case of a surface acoustic wave (SAW) sensor, the piezoelectric material used in the fabrication of the sensor plays a crucial role in defining the response of the SAW sensor. As a ferroelectric material, barium strontium titanate (Ba0.6Sr0.4TiO3) has recently been studied due to its intriguing dielectric and electromechanical properties. Its high acoustic velocity and coupling coefficient make it a promising candidate for the development of acoustic devices; however, its use as a piezoelectric material in SAW sensors is still in its infancy. In this paper, we present the design, fabrication and validation of an indium doped SnO2-based SAW gas sensor on Ba0.6Sr0.4TiO3 thin film for room temperature (RT) applications. Pulsed laser deposition was used to deposit thin films of Ba0.6Sr0.4TiO3 and indium-doped SnO2. Different characterization techniques were employed to analyze the morphology and crystallization of the films. The performance of the fabricated sensor was validated by exposing it to different concentrations of ethanol and then analyzing the recorded frequency shift. The sensor exhibited fast response (39 s) and recovery (50 s) times with a sensitivity of 9.9 MHz/Δ. Moreover, the sensor had good linear response and reproducibility. The fabricated indium-doped SnO2-based SAW gas sensor could be suitable for practical room temperature applications.
Functional Formulation of Quantum Theory of a Scalar Field in a Metric with Lorentzian and Euclidean Signatures
Authors: Haba Zbigniew
Published: April 2024

We study the Schrödinger equation in quantum field theory (QFT) in its functional formulation. In this approach, quantum correlation functions can be expressed as classical expectation values over (complex) stochastic processes. We obtain a stochastic representation of the Schrödinger time evolution on Wentzel–Kramers–Brillouin (WKB) states by means of the Wiener integral. We discuss QFT in a flat expanding metric and in de Sitter space-time. We calculate the evolution kernel in an expanding flat metric in the real-time formulation. We discuss a field interaction in pseudoRiemannian and Riemannian metrics showing that an inversion of the signature leads to some substantial simplifications of the singularity problems in QFT.
Tourism and Economic Misery: Theory and Empirical Evidence from Mexico
Authors: Sánchez López Fernando
Published: April 2024

The misery index (MI) was devised to summarize the most evident costs for a society, attempting to objectively measure the loss in general welfare. It has been remarked in the literature that economic growth exerts a negative impact on the MI; however, analyses of this relationship in the tourism field have been neglected. This study assessed the effectiveness of the tourism sector at improving welfare conditions by measuring the impact of tourism GDP on the misery index and providing a theoretical framework for the relationship between tourism and the MI. A quantitative analysis was conducted using quarterly time series data for the period 2005Q1–2021Q2. Firstly, the existence of a long-term relationship was tested by using the Toda–Yamamoto procedure, and secondly, by applying linear and nonlinear ARDL models. The main results show that tourism can help to reduce the loss of welfare mirrored by the MI. These findings have policy implications, as they provide evidence that expanding the tourism sector counters the MI, and, consequently, the economic malaises derived from it.
University Students’ Achievement of Meaningful Learning through Participation in Thinking Routines
Authors: Ramos-Vallecillo Nora , Murillo-Ligorred Víctor , Lozano-Blasco Raquel
Published: April 2024

This study was conducted among undergraduate students pursuing a Primary Education degree at the University of Zaragoza. Its primary aim was to enhance and elevate the quality of participation during theoretical sessions, thereby fostering meaningful learning that contributes to the improvement of academic performance among the participants. To achieve this objective, a quasi-experimental case study was meticulously crafted. This research design was structured to not only stimulate and augment participation but also to cultivate meaningful learning, ultimately enhancing students’ academic achievements. The study employed a comprehensive approach to monitor participation, utilizing observation records to track engagement levels, and anecdotal records to delineate the progression of sessions and the quality of responses. Through meticulous analysis, it can be deduced that the integration of thinking routines as a pedagogical tool in expository sessions significantly enhances student engagement. These routines effectively activate students’ prior knowledge, establishing meaningful connections with the subject matter at hand. Moreover, the incorporation of thinking routines has been observed to elevate the quality of student participation. By fostering reflective practices, aiding in the formulation of inquiries, promoting collaborative learning, and nurturing critical thinking skills, these routines play a pivotal role in enriching the educational experience and bolstering academic performance.
Inertia Energy-Based Required Capacity Calculation of BESS for Achieving Carbon Neutrality in Korean Power System
Authors: Chae Dong-Ju , Kook Kyung Soo
Published: April 2024

Frequency response performance in power systems is becoming vulnerable due to the transition toward the higher penetration of renewable energy such as achieving carbon neutrality. In particular, reducing power system inertia energy as the asynchronous generation increases could result in violating the frequency stability constraint when a disturbance occurs in the power systems. In order to control the rapidly fluctuating frequency of the power system with low inertia, it is necessary to introduce fast frequency response resources such as a Battery Energy Storage System (BESS). This paper proposes a method to calculate the required capacity of BESS for compensating the frequency control performance of the power system using inertia energy. For calculating the required capacity of BESS, the inertia energy in the critical power system, where frequency control performance marginally satisfies frequency stability constraint, should be calculated. Also, the inertia energy in the evaluated power system having deficit inertia energy should be calculated. By comparing power systems that respond with different dynamics when the same disturbance occurs, the proposed calculation corresponds to the ratio of inertia energy deficiency based on critical power system inertia energy within the power imbalance. Through various case studies employing Korean power systems, the effectiveness of the inertia energy-based calculation method for the required BESS is verified by the fact that the BESS integrated power system marginally satisfies the frequency stability constraint. In these study cases, it is found that the instant response of BESS is very effective for compensating the frequency control performance of the low inertia power system. By applying the proposed method, it is also found that about 840 MW of BESS can achieve carbon neutrality in the Korean power system.
Trends in Measuring Instrument Transformers for Gas-Insulated Switchgears: A Review
Authors: Kim Dong-Eon , Lee Gyeong-Yeol , Kil Gyung-Suk , Kim Sung-Wook
Published: April 2024

Voltage and current measurements in high-voltage substations are fundamental for stable operation. Conventional instrument transformers (ITs) face challenges in gas-insulated switchgears (GISs), such as size, weight, accuracy limitations, and behavioral instability at abnormal voltages and currents. Non-conventional instrument transformers (NCITs) have emerged to address these issues, complying with International Electrotechnical Commission (IEC) standards and providing millivolt-level signals, enabling downsizing of GIS bays. The transition to digital substations, as mandated by IEC 61850-9-2, requires a shift from the conventional 110 V/5 A outputs to levels ranging from millivolts to volts. Electronic instrument transformers (EITs), compliant with the IEC 60044-7 and 8 standards, offer alternatives to conventional ITs with smaller sizes and wider frequency ranges. However, issues remain with EITs, including limited adoption, the necessity of separate power sources, and susceptibility to electromagnetic interference. Recent standards, transitioning to IEC 61869, focus on low-power instrument transformers (LPITs). Low-power voltage transformers (LPVTs) and low-power current transformers (LPCTs), designed with passive components, present potential solutions by directly connecting to merging units (MUs) for digital signal transmission. This review outlines the current status of various IT standards, covering conventional ITs, EITs based on IEC 60044-7 and 8, and LPITs based on IEC 61869-10 and 11. Advancements in sensor technology relevant to these standards are also explored. The paper provides insights into the evolving landscape of instrument transformers, addressing challenges and offering potential pathways for future developments in digital substations.
A Compressible Formulation of the One-Fluid Model for Two-Phase Flows
Authors: El Ouafa Simon , Vincent Stephane , Le Chenadec Vincent , Trouette Benoît , Fereka Syphax , Chadil Amine
Published: April 2024

In this paper, we introduce a compressible formulation for dealing with 2D/3D compressible interfacial flows. It integrates a monolithic solver to achieve robust velocity–pressure coupling, ensuring precision and stability across diverse fluid flow conditions, including incompressible and compressible single-phase and two-phase flows. Validation of the model is conducted through various test scenarios, including Sod’s shock tube problem, isothermal viscous two-phase flows without capillary effects, and the impact of drops on viscous liquid films. The results highlight the ability of the scheme to handle compressible flow situations with capillary effects, which are important in computational fluid dynamics (CFD).