bluuebunny/crossref_metadata_2025 huggingface dataset:
Groundwater level dynamic simulation and soil salinization prediction of the closed hydrogeological unit in the arid irrigation area
Authors: Lian Haidong , Sun Zhaojun , Xu Cundong , Gu Fengyou , Liu Zijin , He Jun
Published: April 2023

Aiming at problems such as inaccurate simulation of groundwater level in closed hydrogeological units, difficult quantitative prediction of soil salinization degree, and unclear water and salt migration, a three-dimensional simulation model of groundwater was established, and the development trend of groundwater level and soil salinization was predicted. The groundwater level simulation results are consistent with the changing trend of the observational data and the simulation model can be used to predict groundwater levels in closed hydrogeological units. When climate scenarios and human activity change are set as future scenarios, the average groundwater buried depth will continue to decrease in the next 10 years, the area with a groundwater buried depth of 0–5 m will exceed 50%, and even the groundwater will overflow to the surface. The change of soil salt content is predicted quantitatively and the salinization degree will develop from ‘saline–alkali soil’ and ‘mild saline–alkali soil’ to ‘medium saline–alkali soil’. The process of water and salt migration in three key hydrologic zones, namely ‘irrigation infiltration’, ‘solute migration’, and ‘water and salt accumulation’, is revealed in the closed hydrogeological unit. The research results can provide new ideas for the improvement of soil and water environment problems.
Characterizing groundwater quality for a safe supply of water using WQI and GIS in Bahir Dar city, northwest Ethiopia
Authors: Asmamaw Menen , Debie Ermias
Published: April 2023

Although both urban and rural residents benefit from drinking enough high-quality water in the right amounts, the degree of contamination from artificial sources has been increasing. The study aims to assess the quality and availability of groundwater potential in Bahir Dar City using geographic information systems (GIS)-based ordinary kriging (OK) and analytical hierarchy process methods, respectively. The concentrations of pH, alkalinity, Escherichia coli, nitrite manganese, and iron in the groundwater of built-up areas were found to exceed the limits set by the World Health Organization. The groundwater quality distribution contained 69.6% of good water, 19.6% of the excellent class, and 10.8% of the poor class. The high potential of groundwater, particularly in the Lake Tana shoreline sedimentation areas, revealed the poor quality class. The results suggest that improving groundwater quality should be prioritized in areas with high potential groundwater availability.
Avaliação histológica da laserterapia de baixa intensidade na cicatrização de tecidos epitelial, conjuntivo e ósseo: estudo experimental em ratos
Authors: Enio Marcos da SILVA  , Shaiene Patrícia GOMES  , Lucienne Miranda ULBRICH  , Allan Fernando GIOVANINI
Published: April 2023

A cicatrização é um processo fisiológico que ocorre diante de injúriascausadas em tecidos vivos. Muitas pesquisas estão sendo realizadasvisando à estimulação do reparo tecidual. O objetivo deste artigo foiavaliar histologicamente a resposta de tecidos epitelial, conjuntivo eósseo submetidos à laserterapia de baixa intensidade (LBI) em ummodelo experimental de reprodução alveolar. Como metodologia,foram realizadas aplicações de LBI em quatro grupos de cinco ratos,nos seguintes parâmetros: 10 mW potência única e 660 nm – 7,5 J/cm2;660 nm – 15 J/cm2 ; 780 nm – 7,5 J/cm2; e 780 nm – 15 J/cm2. Ostempos experimentais foram 3, 7, 14, 21 e 28 dias. Como resultado,os tecidos epitelial e conjuntivo mostraram renovação celular atípicae acelerada durante o período de irradiação; o tecido ósseo teve suaneoformação acelerada, porém de igual padrão ao grupo controle.Concluiu-se que os tecidos epitelial e conjuntivo reagiram àestimulação de LBI com renovação celular constante. No tecido ósseo houve uma aceleração da neoformação e reparação óssea, dentro dospadrões de normalidade.
Prevalência de lesões bucais diagnosticadas pelo Laboratório de Histopatologia do UnicenP
Authors: Isabella Caroline BERTOJA  , Juliana Giongo TOMAZINI  , Ana Paula Ribeiro BRAOSI  , João César ZIELAK  , Luis Francisco Gomes REIS  , Allan Fernando GIOVANINI
Published: April 2023

Foi realizado um estudo retrospectivo de 1.963 lesõesbucomaxilofaciais diagnosticadas pelo Laboratório de Histopatologiada Faculdade de Odontologia do UnicenP/PR no período de 2003 a2006, para demonstrar a prevalência das lesões bucais maisfreqüentes, correlacionando-as com idade e gênero. Os resultadosmostraram 82 variantes histológicas diferentes. O perfilepidemiológico de pacientes acometidos por patologias mostroupercentual maior em indivíduos do sexo feminino (65,82%), commaior freqüência na 5.ª década de vida (24%) e média de idade de44,2 anos. Os dados evidenciaram a hiperplasia fibrosa inflamatóriacomo a lesão mais prevalente (30,6%), seguida de fibroma (21,29%),cisto radicular (5,2%) e mucocele (5,04%).
Treatment of deep bite with bite plate: a case report
Authors: Allan ABUABARA  , José Carlos Faria LAGO
Published: April 2023

Certain aspects of malocclusion, particularly deep bite, can be relatedto periodontal pathology and the healthy of temporomandibular joints(TMJ). In orthodontics, deep bite has always been considered as adifficult anomaly to correct, but also as the one most hindering tosolving the problems resulting from other associated malpositions. Acase report of deep bite and crossed bite of permanent upper leftlateral incisor in a Class I malocclusion and permanent dentitionillustrates the principles of case management. The reduction of deepbite using bite plate (Equi-Plan) showed quick and short time inpermanent dentition (within 4 months). The mesofacial type of thepatient favored the fast treatment of the deep bite, in the same waythat a dolicofacial type also is favorable because of the facial verticalgrowth pattern. In contrast, the braquifacial type demands greatertime to treat the deep bite.
Análise comparativa ex vivo da eficiência na odontometria de três localizadores apicais eletrônicos: Root ZX, Bingo 1020 e Ipe
Authors: Roberta HEIDEMANN  , Felipe VAILATI  , Cleonice Silveira TEIXEIRA  , César Augusto Pereira OLIVEIRA  , Braulio PASTERNAK JUNIOR
Published: April 2023

Introdução e objetivo: O objetivo do presente estudo foi avaliar exvivo a precisão da leitura de três localizadores apicais eletrônicos –Root ZX, Bingo 1020 e Ipex –, em relação à medida real dos dentes.Material e métodos: Foram selecionados 50 dentes pré-molaresextraídos, unirradiculares. Após a abertura coronária, a mensuração do comprimento do dente (CD) foi realizada diretamente pela inserçãode uma lima K#10 no canal até que sua ponta fosse observada noforame apical com auxílio de uma lente de aumento (8X). Após aremoção da lima, seu comprimento foi registrado com precisão de0,01 mm com uso de paquímetro digital. Em seguida, os dentes forammensurados eletronicamente (CE) com os três localizadores apicaisaté atingir a marca 0 no visor de cada aparelho. As medidas obtidaseletronicamente foram comparadas com o CD, e as diferenças,analisadas pelo teste de Kruskal-Wallis e pelo teste de proporções(α = 0,05). Resultados: Verificou-se que o sistema Root ZX foidiferente do Ipex (p < 0,01), e o sistema Bingo apresentou resultadointermediário, mostrando-se estatisticamente semelhante aos sistemasRoot ZX e Ipex (p > 0,05). Dentro do limite de tolerância de ± 1,0mm, os resultados demonstraram uma precisão de 100% para o RootZX, 94% para o Bingo e 90% para o Ipex quando comparados aosvalores do CD. Porém no limite de ± 0,5 mm a precisão obtida foi de90% para o Root ZX, de 68% para o Bingo e de 52% para o Ipex.Conclusão: Todos os dispositivos eletrônicos testados foram hábeisem determinar com precisão o comprimento do dente quandoconsiderada uma variação de 1 mm em relação à posição do forameapical. Entretanto, quando levada em conta uma variação de 0,5 mm,apenas o aparelho Root ZX mostrou-se preciso.
Avaliação da rugosidade do esmalte de dentes bovinos clareados com e sem ativação por laser
Authors: Rafael Canzi Almada de Paula XAVIER  , Rodrigo Mario Pontoni MIRANDA  , Carla Castiglia GONZAGA  , Maria da Graça Kfouri LOPES
Published: April 2023

Introdução: Atualmente, em decorrência da maior demanda porprocedimentos estéticos, os clareamentos tornaram-se rotina nostratamentos odontológicos. O desenvolvimento de novas técnicas emateriais, como os clareamentos ativados por laser, tem sepopularizado, porém, em virtude do pequeno número de publicaçõesnessa área, ainda não se conhece o seu grau de agressividade. Objetivo:Determinar a rugosidade da superfície do esmalte bovino submetido aclareamento com e sem ativação por laser. Material e métodos: Vintee sete incisivos bovinos foram extraídos, limpos e armazenados emtimol a 1% por sete dias e divididos em três grupos (n = 9): I – sem tratamento (controle); II – submetido a três sessões de clareamentocom gel de peróxido de hidrogênio a 37% (Whiteness HP), sendo trêsaplicações de 15 minutos por sessão; III – submetido a três sessões declareamento com o mesmo gel, sendo três aplicações de 9 minutospor sessão ativadas por laser (Whitening Lase II). Entre cada sessão,mantiveram-se os dentes em soro fisiológico. Depois de concluído otratamento clareador, foi determinada a rugosidade superficial doesmalte incisal dos espécimes, utilizando-se o parâmetro Ra. Osresultados foram analisados estatisticamente por meio de Anova e testede Tukey (α = 0,05). Resultados: O grupo I apresentou os menoresvalores médios de rugosidade (2,8 ± 1,7 µm), seguido pelos grupos III(3,8 ± 1,5 µm) e II (4,9 ± 1,8 µm). A única diferença estatisticamentesignificante encontrada foi entre os grupos I e II. Conclusão: O uso dolaser no clareamento não aumentou a rugosidade superficial do esmaltedos dentes bovinos.
Disfunção da articulação temporomandibular em criança
Authors: Fernanda Mara de Paiva BERTOLI  , Estela Maris LOSSO  , Ricardo César MORESCA
Published: April 2023

Introdução e objetivo: Este trabalho teve como objetivo abordaraspectos relacionados às disfunções temporomandibulares (DTM) emcrianças, como etiologia, diagnóstico e tratamento, ressaltando aimportância do diagnóstico correto, uma vez que esses pacientes estãoem fase de crescimento e de desenvolvimento facial. Revisão deliteratura: As DTMs apresentam vários problemas clínicos queenvolvem os músculos da mastigação, articulação temporomandibulare estruturas adjacentes. Em crianças os sintomas dessa síndrome estãopresentes porém com menor intensidade quando comparadas aosadultos. Quanto à prevalência há uma grande discordância entre os autores. As DTMs em crianças possuem etiologia multifatorial, e osfatores mais citados são hábitos parafuncionais, traumas, fatoresoclusais, sistêmicos e psicológicos. Conclusão: Os sinais e sintomasde DTMs em populações pediátricas são geralmente suaves eaumentam com a idade, sendo de grande importância o diagnósticoprecoce e a inclusão desse tipo de exame em consultas de rotina.
Prevalência de cistos maxilares diagnosticados em um centro de referência brasileiro
Authors: Roberto NANAMI  , Carolina SAMPAIO  , Joice OLIVETE  , Eduardo PIZZATTO  , Ricardo MORESCA  , Allan Fernando GIOVANINI
Published: April 2023

Introdução: Entre as patologias mais importantes na Odontologia, destacam-se as lesões císticas, definidas como entidades patológicas comuns que envolvem o complexo maxilomandibular. Objetivo:Avaliar a prevalência de lesões císticas diagnosticadas no Laboratório de Histopatologia da Universidade Positivo (Curitiba), no período de fevereiro de 2002 a agosto de 2006, relacionando-as às variantes etária e de sexo. Material e métodos: Foram estudados 242 casos de cistos odontogênicos registrados e diagnosticados. Os laudos emitidos foram estudados isoladamente quanto à prevalência e à distribuição pelo sexo e idade dos pacientes. Resultados e conclusão: A lesão encontrada com maior frequência foi o cisto radicular, correspondendo a 42% das amostras; seguido pelos cistos de natureza odontogênica (24%), cisto de natureza inflamatória (11%) e queratocisto (10%). O sexo masculino foi acometido mais que o feminino, principalmente entre a terceira e a quinta década de vida.
Study on the Analgesic Activity of Peptide from Conus achates
Authors: Liu Xiujie , Wang Fuli , Yu Huilan , Liu Changcai , Xia Junmei , Ma Yangde , Jiang Hui
Published: April 2023

Background:

As a peptide originally discovered from Conus achates by mass spectrometry
and cDNA sequencing, Ac6.4 contains 25 amino acid residues and three disulfide bridges. Our
previous study found that this peptide possesses 80% similarity to MVIIA by BLAST and that MVIIA
is a potent and selective blocker of N-type voltage-sensitive calcium channels in neurons.

Objective:

To recognize the target protein and analgesic activity of Ac6.4 from Conus achates.

MethodS:

In the present study, we synthesized Ac6.4, expressed the Trx-Ac6.4 fusion protein, tested
Ac6.4 for its inhibitory activity against Cav2.2 in CHO cells and investigated Ac6.4 and Trx-Ac6.4 for
their analgesic activities in mice.

Results:

Data revealed that Ac6.4 had strong inhibitory activity against Cav2.2 (IC50 = 43.6 nM). After
intracranial administration of Ac6.4 (5, 10, 20 μg/kg) and Trx-Ac6.4 (20, 40, 80 μg/kg), significant
analgesia was observed. The analgesic effects (elevated pain thresholds) were dose-dependent.

Conclusion:

This study expands our knowledge of the peptide Ac6.4 and provides new possibilities for
developing Cav2.2 inhibitors and analgesic drugs.
Novel Computational Methods for Cancer Drug Design
Authors: Talluri Sekhar , Kamal Mohammad Amjad , Malla Rama Rao
Published: April 2023

Cancer is a complex and debilitating disease that is one of the leading causes
of death in the modern world. Computational methods have contributed to the successful
design and development of several drugs. The recent advances in computational methodology,
coupled with the avalanche of data being acquired through high throughput genomics,
proteomics, and metabolomics, are likely to increase the contribution of computational
methods toward the development of more effective treatments for cancer. Recent
advances in the application of neural networks for the prediction of the native conformation
of proteins have provided structural information regarding the complete human proteome.
In addition, advances in machine learning and network pharmacology have provided
novel methods for target identification and for the utilization of biological, pharmacological,
and clinical databases for the design and development of drugs. This is a review
of the key advances in computational methods that have the potential for application
in the design and development of drugs for cancer.
The Role of MiR-29 in the Mechanism of Fibrosis
Authors: Wang Min , Huo Zhiying , He Xiaoyan , Liu Fuyou , Liang Jingtao , Wu Lijuan , Yang Dongdong
Published: April 2023

Fibrosis is a pathological process characterized by tissue scarring that can occur in various
human body organs. The fibrosis of the organ is manifested as an increase in fibrous connective
tissue and a decrease in parenchymal cells in the organ tissue, leading to structural damage and
functional decline of the organ. At present, the incidence and medical burden of fibrosis are increasing
worldwide, which has presented severe negative impacts on human health. Although many of
the cellular and molecular processes for underlying fibrosis have been discerned, there are still gaps
for effective therapies and target fibrogenesis specifically. Recent studies have shown that the microRNA-
29 family (miR-29a, b, c) plays an essential role in the process of multiorgan fibrosis. It is
a class of highly conserved single-stranded noncoding RNAs composed of 20-26 nucleotides.
Through its 5' untranslated region (UTR) pairing with the 3'UTR of the target mRNA, the mRNA of
the target gene is degraded to complete the physiological process of inhibiting the transcription and
translation of the target gene. Here, we summarize the interaction of miR-29 with multiple cytokines,
describe the mechanism by which miR-29 regulates major fibrotic pathways such as TGF-
β1/Smad, PI3K/Akt/mTOR, DNA methylation，and found that miR-29 is closely linked to epithelial-
mesenchymal transition (EMT). These findings point to a common or similar regulatory mechanism
by miR-29 in fibrogenesis. Finally, we review the antifibrotic activity of miR-29 mimicked in
current studies and highlight miR-29 as a promising therapeutic reagent or target for the treatment of
pulmonary fibrosis. Besides, there is an urgent need to screen and identify small compounds to
modulate miR-29 expression in vivo.
LINC00839, LINC01671, AC093673 and AC008760 are Associated with
the Prognosis and Immune Infiltration of Clear-cell Renal Cell Carcinoma
Authors: Su Bao-Chang , Yang Sheng-Fu , Ye Xun-Da , Huang Zhang-Xiong , Song Yu-Wei , Xu San-Huang
Published: April 2023

Background:

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney
cancer, and it is a significant global health problem causing significant morbidity and mortality. Long
noncoding RNAs (lncRNAs) have been identified as a class of gene expression regulators that play a
critical role in the immune system. However, the function of lncRNAs in the immune microenvironment
of ccRCC remains unclear.

Methods:

The least absolute shrinkage and selection operator regression techniques, robust likelihoodbased
survival modeling, and Cox regression analysis were used to identify potential prognostic
lncRNAs. The relationship between the signature and the tumor's immune infiltration was analyzed
using gene set enrichment analysis and the subset analysis of immune cells.

Results:

LINC00839, LINC01671, AC093673, and AC008760 were selected to create a risk signature.
For 3-, 5-, and 8-year overall survival rates, the areas under the receiver operating characteristic curves of
the risk signature set were 0.689, 0.721, and 0.719 in the training set and 0.683, 0.686, and 0.665 in the
validation set, respectively. A model and nomogram were constructed using the risk signature and clinical
characteristics. The C-index of the model was 0.78 in the training set and 0.773 in the validation set.

Conclusion:

The risk signature reflects the tumor's current immune infiltration and is associated with
regulatory T cell differentiation, interleukin 17 production regulation, negative regulation of inflammatory
response to an antigenic stimulus, and the IL6-JAK-STAT3 signaling pathway. This study
provides prognostic information for ccRCC patients and may also serve as a useful clue for future
immunotherapies.
A Case Report of Bone Paget's Disease with Concurrent Psoriasis and Positive
Celiac Serology
Authors: Sabooniha Fakhreddin
Published: April 2023

Background:

Paget's disease of bone (PDB) is the second most frequent metabolic bone disease affecting about 3 percent of the Caucasian population older than
55 years. Its etiopathogenesis is unknown. While viral agents like measles and respiratory syncytial virus has been proposed, the role of genetic
susceptibility loci such as SQSTM1/p62 gene mutations have been confirmed. A new inhibitory mechanism against osteoprotegerin (OPG) via
autoantibodies has been revealed in a patient with occult celiac disease (CD) with a phenotype similar to juvenile Paget's disease, which suggests
an immunological mechanism for Paget's disease-like disorders other than genetic causes. But there is no report in the literature addressing the
shared immunological mechanisms underlying classic PDB, CD and psoriasis.

Case Presentation:

Herein, the case of a 50-year-old Caucasian man being reported with progressive bilateral hearing loss. The patient had a history of total blindness
which had developed shortly after a cranial osteotomy for optic nerve decompression without any specific diagnosis 15 years ago. He had also
been suffering chronic psoriasis vulgaris. Because of his enlarged skull, a diagnosis of bone Paget's disease was suspected and plain radiographs
revealed a polyostotic Paget's disease with characteristic radiologic signs. In searching for his refractory constipation causes, an elevated level of
tissue transglutaminase IgA (tTG IgA) antibody was demonstrated. Alendronate sodium 40 mg daily was started and a gluten-free diet was
recommended to him but he was not adherent to the treatments and lost to follow-up.

Conclusion:

This case further supports the idea of considering PDB as an osteoimmunologic disorder, like psoriasis and CD, because of similar biochemical
features, including elevated levels of Cytokines such as interleukin-6 and tumor necrosis factor- α as well as bone resorption markers such as OPG
and urinary deoxypyridinoline. So, the treatment of Paget’s disease of the bone may benefit from progresses in osteoimmunology-targeted
therapies. Also a probable causal relationship between PDB and CD either by production of neutralizing antibodies in CD against OPG or by
inducing PDB in genetically susceptible patients through oxidative stress, has been postulated here.
Objective Evaluation of Oral and Pharyngeal Areas in Autopsy Cases of
Obstructive Sleep Apnea Syndrome via Postmortem CT
Authors: Takeuchi Akiko , Hyodoh Hideki , Jin Shigeki , Tanaka Satoshi , Murakami Manabu , Minowa Kazuyuki , Matoba Kotaro
Published: April 2023

Background:

Obstructive sleep apnea syndrome (OSAS) can cause sudden death during sleep. Previous findings have suggested that OSAS development is
related to maxillofacial morphology. Evaluation of facial morphology can determine the risk of developing the disease, and establishing an
objective method to assess the underlying etiology of OSAS-related death would be advantageous.

Objective:

The objective of this study is to determine the key features of obstructive sleep apnea syndrome (OSAS) using postmortem oral and pharyngeal
computed tomography (CT).

Methods:

We retrospectively assessed autopsy cases of patients with (n=25) and without (n=25) OSAS-related death. We used oral and pharyngeal CT
images to compare the oral and pharyngeal cavity volume (OPCV), oral and pharyngeal soft tissue volume (OPSV), oral and pharyngeal air space
volume (OPAV), and OPAV to OPCV ratio (%air). Receiver operating curve (ROC) analysis was used to determine the accuracy of OSAS
prediction. We assessed participants with body mass index (BMI) values within the normal range.

Results:

Among the 50 subjects, we observed significant between-group differences in OPSV, OPAV, and % air, whereas there were significant betweengroup
differences in OPSV and %air among 28 subjects with normal BMI values. Both comparisons suggested that OSAS-related death was
associated with low %air and high OPSV values.

Conclusion:

The % air and OPSV are useful for assessing postmortem oropharyngeal CT images. OSAS-related sudden death is likely when %air and OPSV
values are ≤20.1% and ≥127.2 ml, respectively. Among those with normal BMI values, % air and OPSV values of ≤22.8% and ≥111.5 ml,
respectively, predict OSAS-related sudden death.
Screening and in vitro Biological Evaluation of Novel Multiple Tyrosine Kinases Inhibitors as Promising Anticancer Agents
Authors: Li Xiuying , Ruan Pinglang , Jiang Gang , Zhang Weidong
Published: April 2023

Background:

Tyrosine kinases have emerged as key stimulatory drivers in several cancer-related pathways.
This is particularly evident in non-small cell lung cancer with regulating cell growth and apoptosis and so on. Tyrosine
kinase inhibitors (TKI) are one breakthrough option that could improve the life quality of cancer patients.

Objective:

This study aims to find more effective tyrosine kinase inhibitors.

Methods:

In this study, natural products from TargetMol that may be the potential TKI for lung cancer were screened
through structure-based virtual screening and experimental validation. Moreover, the binding between the hit compounds
and tyrosine kinase was explored.

Results:

From the study findings, Gramicidin and Tannic acid have strong interactions with the four tyrosine kinases
(ALK, TRK, MET, and ABL), and this could significantly inhibit the viability of A549 cells in a concentrationdependent
manner.

Conclusion:

These findings indicated that Gramicidin and Tannic acid might be potential multiple TKI and are promising
anticancer agents that call for further study.
A Study of Antibacterial Effect of Nigella sativa Seed Extracts on Bacterial
Isolates from Cases of Wound Infection
Authors: Babu Boinu , Rao Pooja , Suman Ethel , Udayalaxmi Jeppu
Published: April 2023

Background:

With an increasing trend of pathogenic bacteria developing resistance to the
existing drugs, there is a need for newer therapeutic measures. Nigella sativa seeds and oil have been
used for decades as Ayurveda, Unani Tibb and other forms of traditional medicine for various disorders.
Thymoquinone is one of the active components of the N. sativa seeds.

Objective:

The present study determines the antibacterial effect of crude methanolic extract N. sativa
seeds and thymoquinone against bacteria causing wound infection.

Methods:

Samples obtained from cases of wound infection received at a Microbiology laboratory attached
to a tertiary care hospital over a period of six months were included in the study. The antibacterial
effect of crude methanolic extract of N. sativa seeds was determined by the Punch Well method.
The minimum inhibitory concentration (MIC) of thymoquinone against bacteria isolated from cases of
wound infection was determined by the Micro Broth Dilution technique.

Results:

A total of 60 isolates were collected from 60 samples of wound infection. By the Punch Well
method, Staphylococcus aureus showed varying zones of inhibition whereas all gram-negative bacilli
and Enterococcus faecalis did not show any zone of inhibition. Thymoquinone showed good antibacterial
activity against S. aureus with MIC values ranging from 2-8μg/ml for most of the isolates. Uniformly,
MIC of thymoquinone against all gram-negative bacilli and E. faecalis was >128μg/ml,
p<0.001. It was found that methicillin-resistant S. aureus (MRSA) isolates showed higher MIC than
methicillin sensitive S. aureus (MSSA) isolates p<0.05.

Conclusions:

Antibacterial activity of thymoquinone was very good against S. aureus but showed
limited activity against Enterobacteriaceae members and E. faecalis isolated from patients with wound
infection. Thymoquinone may be considered a potential antibacterial agent against wound infection
caused by S. aureus.
Dexamethasone Acetate Nanocrystals, Characterization and Dissolution
Studies in Presence of Polymorphic Phases
Authors: Lemos Barbosa Thúlio Wliandon , da Gama  Bastos Flavia Lemos Ayres , da Silva Bruna Lallo , Junior João Augusto Oshiro , Chiavacci Leila Aparecida
Published: April 2023

Background:

A drug with poor water-solubility, like Dexamethasone acetate, can present
lower bioavailability conventional for pharmaceutical formulations, and the presence of polymorphs in
the raw material can lead to drug quality problems.

Objective:

In this study, nanocrystals of dexamethasone acetate were synthesized by high pressure homogenizer
(HPH) method in surfactant poloxamer 188 (P188) solid dispersion and the bioavailable in
raw material with polymorphism presence was evaluated.

Methods:

The powder pre-suspension was prepared by the HPH process, and the nanoparticles formed
were incorporated in P188 solutions. The nanocrystals formed were characterized by techniques of
XRD, SEM, FTIR, thermal analysis by differential scanning calorimetry (DSC) and thermogravimetric
analysis (TGA), dynamic light scattering (DLS) to analyze the particle size and zeta potential, and in
vitro evaluation by dissolution studies.

Results:

The characterization techniques were adequate to show the presence of raw material with physical
moisture between two dexamethasone acetate polymorphs. The nanocrystals formed in the presence
of the P188 in the formulation showed a considerable increase in the rate of dissolution of the drug in
the medium and in the size of the stable nanocrystals, even in the presence of dexamethasone acetate
polymorphs.

Conclusion:

The results showed that it was possible to produce dexamethasone nanocrystals by HPH
process with regular size by the presence of the small amount of P188 surfactant. This article presents a
novelty in the development of dexamethasone nanoparticles that have different polymorphic forms in
their physical composition.
ЗАХВОРЮВАННЯ ЩИТОПОДІБНОЇ ЗАЛОЗИ ТА ЦЕЛІАКІЯ: ОГЛЯД ЛІТЕРАТУРИ ТА ВЛАСНІ ДОСЛІДЖЕННЯ
Authors: Хижняк Оксана , Ніколаєв Роман , Манська Катерина , Олексик Ольга , Плехова Олена
Published: April 2023

Хронічне аутоімунне захворювання щитовидної залози (ЩЗ) або тиреоїдит Хашимото (АІТ) є одним із основних аутоімунних захворювань ЩЗ у дитячому віці. Характеризується продукцією антитиреоїдних антитіл, інфільтрацією аутореактивних В- та Т-лімфоцитів у паренхіму ЩЗ та, як наслідок, змінами функції ЩЗ (еутиреоз або субклінічний гіпотиреоз при АІТ з можливою еволюцією у бік маніфестного гіпотиреозу). Целіакія (Ц) - це системне аутоімунне захворювання, викликане вживанням в їжу глютена у генетично схильних суб'єктів, його поширеність становить близько 1% у західних країнах. Проявляється патогномонічною ентеропатією, різноманітністю клінічних проявів, позитивним титром специфічних антитіл, наявністю типових гаплотипів HLA DQ2/DQ8. Ц може бути варіантом коморбідної патології при різних аутоімунних ендокринопатіях, таких як АІТ, цукровий діабет 1 типу, хвороба Аддісона, поліендокринні синдроми. У статті проаналізовано дані літератури за останні 40 років про зв'язок між тиреопатіями та глютеновою хворобою як у дорослому, так і дитячому віці, а також представлені власні дані про частоту Ц у дітей з АІТ.
Determination of Engineering Properties of Coleus Pertinent to the Design of a Digging-cum-Windrowing Unit
Authors: SURAJA A R , JAYAN P R
Published: April 2023

Coleus (Solenostemon rotundifolius) is an important minor tuber crop grown in the homesteads of Kerala and Tamil Nadu. There was a demand for mechanisation for harvesting the tuber because the conventional method of harvesting followed was tedious and time-consuming. For the design and development of a coleus harvester with reduced drudgery, the design parameters were selected with respect to the tuber properties. Random sampling was carried out for determining the physical and frictional properties of coleus. The average values of physical properties such as length, width, thickness, geometric mean diameter, sphericity, surface area, volume and bulk density were found out as 44.56 mm, 27.36 mm, 24.50 mm, 30.99 mm, 0.70, 3029.69 mm2, 15786.50 mm3 and 718.21 kg m-3 respectively. The angle of repose was determined as 30.83° and the coefficient of static friction was found out as 0.73, 0.69 and 0.81 on galvanised iron, stainless steel and plywood surfaces respectively. These data were used for the design of various components of the harvester.
Assessing Patients’ Critical Health Literacy and Identifying Associated Factors: Cross-sectional Study
Authors: Shan Yi , Ji Meng , Dong Zhaogang , Xing Zhaoquan , Xu Xiaofei
Published: April 2023

Background

Previous studies have revealed that functional health literacy plays a less important role than communicative and critical health literacy (CRHL) and that communicative literacy and CRHL contribute more to better patient self-management. Although improving health literacy has been identified as an approach to fostering community involvement and empowerment, CRHL may be regarded as the neglected domain of health literacy, rarely achieving any focus or interventions that claim to be working toward this outcome. Considering this research background, close scholarly attention needs to be paid to CRHL and its associated factors.

Objective

This study aimed to assess CRHL and identify essential factors closely associated with the status of CRHL among Chinese patients and to provide some implications for clinical practice, health education, medical research, and public health policy making.

Methods

We conducted this cross-sectional study, which lasted from April 8, 2022, to September 23, 2022, following the steps below. We first designed a 4-section survey questionnaire and then recruited Mandarin Chinese–speaking patients from Qilu Hospital of Shandong University, China, using randomized sampling. Subsequently, we administered the questionnaire via wenjuanxing, the most popular web-based survey platform in China, between July 20, 2022, and August 19, 2022. Finally, we used latent class modeling to analyze the valid data collected to classify the patient participants and identify the factors potentially associated with different CRHL levels.

Results

All data in the 588 returned questionnaires were valid. On the basis of the collected data, we classified the patient participants into 3 latent classes of limited, moderate, and adequate CRHL and identified 4 factors associated with limited CRHL, including middle and old age, male sex, lower educational attainment, and low internal drive to maintain one’s health.

Conclusions

Using latent class modeling, we identified 3 classes of CRHL and 4 factors associated with limited CRHL among the Chinese study participants. These literacy classes and the predicting factors ascertained in this study can provide some implications for clinical practice, health education, medical research, and health policy making.
Length-Weight Relationship and Condition Factors of Sarotherodon galilaeus (Linnaeus, 1758) from Nguru-Gashua Wetlands, Northeast Nigeria.
Authors: Segun Ashley-Dejo Samuel , Abubakar Idi-Ogede Musa , Sabo Mohammed , Musa Musa Alhaji , Ijabo Ogah Samuel
Published: April 2023

This study examined the length-weight relation and condition factor of Sarotherodon galilaeus (Linnaeus, 1758) from Nguru-Gashua wetlands, Northeast, Nigeria. A total of 375 specimens were purchased from local fishermen at the designated landing sites for six months. Results of morphometric characteristics showed that the body weight of male S. galilaeus ranged from 127-770 g (601.7±28.01) and females ranged from 272 – 704 g (711.3±38.12). Meristic features show that spinous anal fin rays were constant in both sexes while soft dorsal fin rays, pectoral fin rays, soft anal fin rays and spinous dorsal fin rays had the same range for both sexes. The sex ratio (1:2.18) observed in this study tends to favour male species but contrasts with the general assumption of a sex ratio of 1:1. Mean coefficient of determination was 0.89±0.07 and 0.87±0.07 for male and female S. galilaeus respectively indicating that length-weight relationship model is very reliable. This implies that the change in weight of the sampled fish was caused by 88.52% and 86.68% change in length of male and female S. galilaeus respectively.  It was further revealed that both sexes (b = 2.86±0.18 and 2.88±0.35) had negative allometric growth patterns. The wetland's environmental conditions were within a tolerable range for cichlids.
Stylophora pistillata: Effect of Fragment Size and Water Depth on Growth Rate of Transplanted Coral
Authors: Widiastuti Kadek Andina , Yuni Luh Putu Eswaryanti Kusuma , Astarini Ida Ayu
Published: April 2023

Coral transplantation activities are carried out as conservation efforts to save coral reef ecosystems and the species that live and depend on these ecosystems. In its implementation, knowledge regarding effective and efficient transplantation methods is required. The aim of this research was to determine the effect of fragment size and water depth on the growth rate of transplanted Stylophora pistillata at Serangan Beach. By knowing this, coral transplantation activities can be carried out effectively. Field research was carried out from November to April 2022 using the Randomized Block Design method with two factors, namely depth variation (1 m, 3 m, and 5 m) and initial fragment sizes (3 cm, 5 cm and 7 cm). This study used 135 fragments of Stylophora pistillata. The analysis showed that the fragment sizes of 3 cm, 5 cm and 7 cm had significant differences in the rate of coral growth. However, based on the depth variation, only the depth of 1 m differed significantly from the other two depths. The best coral growth rate was observed in corals using an initial fragment size of 7 cm which was transplanted at a depth of 1 m with the highest average growth rates of 0.93 cm/month (height) and 0.79 cm/month (width). Based on the results, it was also known that the number of corals remaining at the end of the study was 265 fragments so the value of survival rate from transplantation activities was 97.78%. Maintaining environmental water conditions and carrying out maintenance and cleaning corals from algae and sedimentation needs to be carried out intensively to maintain the survival rate on Serangan Beach.
Adverse events following immunization associated with the ChAdOx1nCoV-19 and BBV152 vaccine - a cross-sectional study
Authors: Prasad T. S Dr. Durga , Gouru Guna , Vasuprada S. , Sandhya B. , Priya D.S. Kavi , Sudhakar T.
Published: April 2023

COVID-19, an infectious disease, has become a leading cause of death in many people. The rapid emergence of the pandemic prompted the development of a vaccine to mitigate the disease's harmful consequences. Vaccination is the only effective way to prevent infection from spreading and build immunity to the virus. However, developing adverse effects has become a major problem for vaccine reluctance. Accordingly, the interest has been shifted towards identifying the adverse effects developed following immunization. The current study objective is to assess and compare the intensity of adverse effects following 1st and 2nd dose of COVID-19 vaccination and the medication administered to relieve the symptoms associated with vaccination. A cross-sectional study was performed in a community over six months. A total of 836 participants were involved in the study. All the data regarding the vaccination were collected through a specially designed questionnaire form and analyzed in all the participants within the study group. According to the study, at least 1 AEFI was developed in about 90% of the study population. The most common systemic and local effect developed in the study population was fever (59.42%) and pain at the injection site (69.82%), respectively. With both vaccines (ChAdOx1 nCoV-19 and BBV152), the incidence and severity of AEFIs were lower after the second dose than after the first dose, and most of the symptoms associated with vaccination were alleviated by taking home remedies and symptomatic treatment. The adverse effects reported after receiving the ChAdOx1 nCoV-19 and BBV152 vaccines are typical of most vaccines, and the majority of them were tolerated, and most subsided in less than 24 hours.
SOCIAL INFRASTRUCTURE AS A SIGN OF LABOR RELATIONS IN THE FIELD OF ENSURING THE LIFE OF THE POPULATION
Authors:   Омский государственный университет им. Ф. М. Достоевского, Омск, Россия, Кирилл Викторович Пятков
Published: April 2023

Within the framework of this article, the author analyzes the term "social infrastructure", as well as the procedure for its application in modern Russian legislation, the author also examines the content of this term in various areas of jurisprudence, in order to develop common approaches to determining the signs of labor activity in the field of ensuring the life of the population.
Skills Acquisition and Employability Among Arts and Social Sciences Interns in a Malaysian Public University
Authors: Monogaran Mythili , Subramaniam Thirunaukarasu
Published: April 2023

Many Malaysian employers feel that university curricula inadequately prepare graduates for the realities of the job market. The present study attempts to rank skills acquisition among interns at a Malaysian public university and identify the gaps through skills gap and radar analyses. Respondents comprised students from an Arts and Social Sciences faculty in a Malaysian public university who had undergone internship as well as the employers who conducted trainings for them. Using a simple random sampling method, 164 students and 43 employers provided responses. The largest gap between employers’ expectations and interns’ performance is seen for ‘values, attitudes and professionalism’. Employers tend to emphasise ‘values, attitudes and professionalism’ as an essential skill for employability. Positive qualities, such as having good work habits and attitudes, are valuable assets that need to be inculcated. Another skill that requires improvement is ‘communication, leadership and team skills’, as poor communication skills can become a serious obstacle for employability. This study provides insights from a dual perspective analysis through the identification of gaps between actual and expected intern performance. This information will be a valuable guideline in redesigning university modules to meet the demands of potential employers.
The Multifaceted Fielding
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences
Published: April 2023

This volume of essays, collected and edited by a well-known Russian scholar and specialist in English literature Ekaterina P. Zykova (1954–2018), deals with a wide range of issues relevant to the students of Henry Fielding (1707–1754), a prominent playwright and novelist of the 18th century. The main purpose behind this work is to recreate, feature by feature, a 3D, multifaceted portrait of the English major writer, who united in himself great qualities of a comediograph, a moralist, a pamphleteer concerned with social matters, a journalist, a jurist and magistrate, an etymologist. This Russian-language study directs inquiry to Fielding’s contribution to World literature and culture, to his life and afterlife. Among the volume’s contributors there are scholars from the Russian Academy of Sciences, from Smolensk State University, from Oles Honchar Dnipro National University and other specialists in the field. The book will appeal to literary scholars, theatre critics, historians and to wide audience interested in the history of West European culture and literature.
Authorial Position and the Function of Metatext in the Novels by Fielding and Sterne
Authors: Atarova Kseniya N.
Published: April 2023

The article offers a comparative analysis of the uniqueness of the authorial positions and ways of using a metatext in works by Fielding and by Stern. A metatext is understood here as imbuing of the texture of the work with information concerning the principles of its creation and an idea of its author and reader. The very existence of a metatext gives out the presence of the author-demiurge and, consequently, points to the fictitious, created nature of the work. Fielding seems to be the first who introduced this kind of metatext into the texture of novel. The authors before Fielding attempted to imitate and document reality. The authorial position declared by Fielding offers nearly unlimited possibilities of depicting the outer and the inner world of his characters, unlike it happens in memoirs or in epistolary novel. Tristram Shandy by Sterne is a memoir-novel. However, by vesting his narrator with authorial powers, who uses a metatext even more extensively than Fielding, Sterne manages — in the memoir-novel mode — to create almost limitless authorial perspective.
Henry Fielding’s Linguistic Games
Authors:   Oles Honchar Dnipro National University, Potnitseva Tatiana N.
Published: April 2023

The article focuses on H. Fielding’s “A Modern Glossary” that, as it seems, does not correspond to a creation of fiction. Nevertheless namely it convinces in the polysemy and multifunctionality of the playful character of the English writer’s creative art. This playful mode of his works, which literary critics more often link with the aesthetics of Rococo, is not yet attracting a serious attention of investigators. “A Modern Glossary” is Fielding’s ironic-satirical response to the pure linguistic phenomenon — an obvious need of the literary language normalization—as well as to the social-cultural problems, embodied in the language: the fragility and ambiguity of the word “norms” and “rules” of usage, established by the society. The writer’s focusing on the Word in that work provided another projection on a man and the world no less than the utterances of philosophers and all those who tended to the “authentic” lifelikeness in the art.
ANALISIS NILAI TAMBAH SUKUN MENJADI KERIPIK SUKUN PADA INDUSTRI RAJA BAWANG DI KOTA PALU
Authors: Indah Agung , Lamusa Arifuddin , Wibawa I Gede Laksana
Published: April 2023

Penelitian ini bertujuan untuk mengetahui nilai tambah yang diperoleh buah sukun setelah diolah menjadi keripik sukun pada industri Raja Bawang di Kota Palu. Lokasi penelitian ditentukan secara sengaja (purposive), yakni pada industri Raja Bawang yang terletak di Jl. Abdul rahman Saleh No. 33 Kelurahan Birobuli Utara Kecamatan Palu Selatan Kota Palu. Penelitian ini dilaksanakan pada Bulan Mei-Juli 2022. Responden pada penelitian ini adalah pimpinan, bendahara dan karyawan industri Raja Bawang di Kota Palu. Analisis yang digunakan adalah analisis nilai tambah (Metode Hayami). Hasil penelitian menunjukan bahwa nilai tambah yang diperoleh dari hasil pengolahan sukun menjadi keripik sukun sebesar Rp60.495/kg, dengan keuntungan sebesar Rp48.495/kg atau sebesar 80,16%. Nilai tambah yang diperoleh tergolong pada rasio nilai tambah tinggi (diatas 40%), hal ini dipengaruhi oleh besarnya nilai output, harga bahan baku, dan nilai sumbangan input lain. Produksi keripik sukun pada industri Raja Bawang selama Bulan Juli Tahun 2022 menggunakan 250 kg sukun dan menghasilkan 125 kg keripik sukun, 1 kg sukun menghasilkan 500 gram keripik sukun. Besarnya pendapatan produksi keripik sukun pada industri Raja Bawang sebesar Rp 5.887.855.
Trend on public administration research: Bibliometric analysis
Authors: Ismail Ismail , Hartati Sri
Published: April 2023

Public administration has become the main force for society as well as the government. Given the relevance and urgency of public administration research, this research aims to present publications on public administration research from the Scopus database using bibliometric analysis. The method of this research is qualitative methods using Publish or Perish by Harzing for citations in the form of metrics, Microsoft Excel for frequency analysis, and VOS viewer for data visualization with period time 2010–2021. Based on the research results, the publications on public administration research have been consistently increasing since 2015 with 656 citations. The most popular keywords identified in the document set are development, drug administration, food and practice, China, impact, public administration review and state, application, public administration research, big data, future, case, evolution, and efficiency. The relevance of public administration research probably lies in striking the right balance between application and theory development. On the one hand, public administration research should expose researchers to real-life managerial challenges and give them the necessary tools to implement policy successfully. On the other hand, it should also expose public administration researchers to critical thinking and empower them to engage in governance and societal challenges, propose theoretical solutions and build new theories.