bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Nano Cerium Dioxide on Intestinal Microflora in Rats by Oral Subchronic Exposure
Authors: ye Qianru , Jia Dantong , Ji Jun , Liu Yang , Wu Gang
Published: April 2023

Objective: To investigate intestinal toxicity in rats and effects on intestinal flora after oral subchronic exposure to nano cerium dioxide.
Method: Forty healthy male SD rats were randomly divided into four groups: a control group (deionized water) and groups treated with different doses of nano ceria (e.g., 20 mg/kg, 100 mg/kg, and 500 mg/kg), with 10 rats in each group. The rats were given intragastric administrations (every other day) for 90 days. After the last intragastric administration, fresh fecal samples were collected by pressing the abdomen, and the animals were sacrificed. Jejunum, ileum and cecum tissues were retained for pathological analysis by Hematoxylin-eosin staining. The stool samples of rats were sequenced by the Illumina NovaSeq sequencing platform, and the sequencing results were further analyzed by QIIME2 software.
Results: The histopathology results showed that compared with the control group, in the middle- and high-dose groups, epithelial tissue was shed, lamina propria glandular structures were damaged or disappeared, and large numbers of inflammatory cells were distributed in the mucosa. The intestinal flora results showed that there were no significant differences in the α-/β-diversities in each dose group compared with the control group (P>0.05). Compared to the control group, the intestinal pathogenic bacteria, Mucispirillum and Streptococcus, increased significantly after nanocerium dioxide ingestion, while Weissella decreased. The abundances of Akkermansia in all dose groups were higher than in the control group, but the abundances decreased with increasing exposure dose. MetagenomesSeq analysis showed that, compared with the control group, the abundances of S24-7, Lactobacillus and Clostridiales in all experimental groups significantly decreased.
Conclusions: There was no significant difference in gut microbiota diversity after subchronic oral exposure to nanocerium dioxide,but there can affect the structure and abundance of intestinal microflora in rats, and long-term exposure to high doses (>100 mg/kg) causes enteritis
Plasma-derived exosomal miR-326, a prognostic biomarker and candidate for treatment of drug resistant pediatric acute lymphoblastic leukemia
Authors: Saffari Neda , Rahgozar Soheila , Sahin Fikrettin
Published: April 2023

Background Acute lymphoblastic leukemia (ALL) is a cancer with high incidence rate in pediatrics and drug resistance is a major clinical concern for ALL treatment. The current study was designed to evaluate the role of exosomal miR-326 in diagnosis and treatment of children with B-ALL.Methods Exosomes were isolated from plasma samples of 30 patients and B-ALL cell lines through 2 different methods. Exosomes were then characterization, using nanoparticle tracking analysis, immunoblotting assay and electron microscopy. qRT-PCR was employed to measure the expression levels of miR-326. Exosome uptake was validated using transfection procedure. MTT assays were performed to investigate cells viability.Results qPCR showed significant increased levels of miR-326 in patients exosomes compared with non-cancer controls (P < 0.05, AUC = 0.7500). Moreover, a comparison between the sensitive and drug resistant patients revealed a prognostic value for the exosomal miR326 (P < 0.05, AUC = 0.7755). Co-culture studies on drug resistant patient primary cells and B-ALL cell lines suggested that exosomes with high miR-326 level act as vehicles for reducing cells viability. B-ALL cell line transfection with naked miR-326 mimic confirmed the aforementioned results, and fluorescence microscopy validated uptake and internalization of exosomes by target cells.Conclusions The novel introduced features of the exosomal miR-326 addresses a non-invasive, unique way of diagnosing primary drug resistance in pediatric ALL and establishes a novel therapeutic strategy for this cancer.
The Principle of Luck Conservation: Unlucking the Secrets of Luck Using Conjugate Variables
Authors: Farshi Esmaeil
Published: April 2023

The concept of luck has long been an enigmatic and elusive factor in determining success or failure in various aspects of life. This paper presents a groundbreaking principle, the Law of Luck Conservation, inspired by the uncertainty principle and the concept of conjugate variables in physics. By demonstrating the intricate relationship between complementary variables, we aim to provide a practical framework for understanding and leveraging luck in competitive settings such as sports competitions, job interviews, and auctions. Additionally, we introduce the Concept of Luck Clustering, which explores the temporal patterns of luck and its apparent clustering in certain situations or time periods, offering insights into phenomena such as continuous winning streaks in sports or financial markets. This innovative approach has the potential to revolutionize our understanding of success and achievement even in gambling. The importance of the Luck Principle can be highlighted through the following points: Foundational knowledge, Unifying diverse fields, Guiding experimentation and research, Educational tool, and Decision-making and problem-solving. Based on the Principle of Luck Conservation, researchers can develop laws, concepts, and theorems. We have presented the Law of Luck Perception and Luck Equilibrium theorem as examples among many laws and theorems derived from the Luck Principle. By presenting the Luck Principle and its applications, we aim to revolutionize our understanding of success and achievement, allowing individuals to better navigate uncertainty and improve their prospects in various aspects of life.
Development of room-temperature fermented stinky sea bass and novel insights into its physicochemical and flavor formation and microbial diversity
Authors: Xiao Hong , Feng Tingyu , Yu Jiao , Hu Mengyue , Liu Hongying , Jiang Xiaoming , Zhang Tao , Xue Yong , Xue Changhu
Published: April 2023

This study created room-temperature fermented stinky sea bass (RFSB) and reported the first analysis of the dynamic changes in physicochemical properties, volatile compounds, and bacterial communities during the fermentation process. The texture of RFSB improved after fermentation, and proton freedom and mobility were reduced. The pH of sea bass increased, while the brightness and whiteness decreased with fermentation. The total concentrations of umami amino acids, pleasant-tasting amino acids, free amino acids, and guanosine-5′-monophosphate (GMP) significantly increased following fermentation, contributing to the freshness of RFSB. Twenty-eight flavor substances were detected during RFSB processing, including trimethylamine and indole, which may account for the stinky nature of RFSB. Tetragenococcus was positively correlated with texture, pH, GMP, and free amino acids of RFSB. Achromobacter, Staphylococcus, Corynebacterium, Tetragenococcus, and Kurthia were significantly correlated with RFSB flavoring substances. This study can be used to guide future research on starter screening.
Latin Hypercube Design for Big Data
Authors: Zhou Xiaojian , Jiang Ting
Published: April 2023

Being notoriously difficult to analyse with classical analytical tools due to its volume, heterogeneity, quality and complexity, Big Data introduce new computational and statistical challenges to data scientist. When the massive sample size exceeds the capacity of the standard statistical methods/software platforms/equipments, employing design of experiment (DOE) to extract a subset of the Big Data becomes a reasonable way. In this paper, a new methodology is proposed to deal with Big Data. We design a novel Latin Hypercube Design (LHD) to get samples in Big Data while guaranteeing the projective and space-filling properties of the classical LHD at the same time.
Geographical Distribution Studies on common pistachio psylla, Agonoscena pistaciae Burckhardt and Lauterer (Hem.: Aphalaridae) in Iran
Authors: Fakoori Hamed , Sanatgar Elham , Lashkari Mohammad reza , Sedaghatfar Ezatollah
Published: April 2023

The common pistachio psyllid, Agonoscesna pistaciae is a key pest of pistachio trees in Iran. Both adults and nymphs cause great economic damages by sucking sap and produce large amounts of honeydew. The geographical distribution of this pest was studied using maxEnt in different climates of Iran. In the present study, Field experiments were conducted during 2019–2020 on pistachio trees and records of 732 specimens collected from 24 climates of Iran in addition to altitude and climate variable data were used for modeling analysis. The results show that northwest of Iran with climatic characteristics of mild winters; warm summers and arid regime were the most suitable areas for A. pistaciae, while the central, west and southeast regions of Iran with very high temperatures were predicted to be less suitable. The habitat distribution patterns for some species such as A. pistaciae can be modeled using a small number of occurrence records and environmental variables using MaxEnt and could be used in plant protection and implementation of integrated control programs.
M-PBBST(n1, n2) : Multiple Partially Balanced Binary Search Trees in one
Authors: ZEGOUR D.E
Published: April 2023

In this paper, we present a new binary search tree to generate known data structures such as Red-Black trees, AA trees, 2–3 trees and several other very interesting data structures that are unknown to us. The proposed data structure partitions the elements of a binary search tree into unbalanced sub-trees of heights ranging from n1 to n2-1 (0 ≤ n1 ≤ n2-2 & n2 > 1). The algorithms are simple and use only a few extra bits of storage at the tree node. Moreover, a single code covers all generated data structures and the worst case height is
Interest-aware Collaborative filtering Recommendation Model based on Graph Neural Networks
Authors: Joshi Rohan , Patel Shreya , Smith Sybilla , St.Dawson Humphrey
Published: April 2023

Recommendation systems have become an integral part of various online platforms, providing personalized recommendations to users while reducing information overload. Graph Convolution Neural Network (GCN) based models have become the most popular research method in recommendation systems. These models have the ability to learn embedding representations on graph structures, which makes them effective in modeling recommendation systems. However, the GCN model suffers from the oversmoothing problem, which makes node representations indistinguishable after multiple layers of graph convolution. Researchers have proposed models such as LR-GCN, Light-GCN, DropEdge, and IMP-GCN to mitigate this problem. Despite the significant advancements in GCN-based models, they still do not take full advantage of higher-order neighbors' covariance signals. Additionally, they do not consider the influence of users' different opinions on the recommendation results when propagating and aggregating synergistic signals. This paper proposes a graph convolutional neural network recommendation model with interest-aware message delivery that utilizes 2nd-order neighbors' cooperative signals and users' views to improve accuracy in learning node embeddings. Our model separates subgraphs for users and products, allowing for intergroup crossover in the classification. The proposed model addresses the shortcomings of current GCN-based models, and it is evaluated on several datasets. The results show that our model outperforms state-of-the-art models in terms of prediction accuracy, making it a promising recommendation model for various applications.
Increasing Sales Through Social Media Marketing: The Role of Customer Brand Attachment, Brand Trust, and Brand Equity
Authors: Heidari Shahin , Zarei Mehrnaz , Daneshfar Alireza , Dokhanian Saeid
Published: April 2023

This study examined the impact of social media marketing on online purchase intention, with brand attachment, brand trust, and brand equity acting as mediating factors. The problem addressed in this research is the lack of understanding regarding the reasons for low adoption of online shopping in Iran despite the increasing popularity of the internet, and the originality lies in exploring the factors and proposing and testing a conceptual model that influence Iranian customers’ decision to buy online. To conduct an empirical case study, we selected Digikala, the largest online two-sided marketplace platform in Iran. To gather data from a representative sample of Digikala customers, a simple random sampling method was utilized. An online survey questionnaire was administered to 363 participants, ensuring a diverse range of respondents were included in the study. A partial least squares method was used to analyze the data using the structural equation modelling (SEM) method by SmartPLS software. The results of the research study demonstrated that social media marketing creates positive changes in brand equity, customer attachment to the brand, brand trust, and online purchase intent over time. Online purchase intention, brand trust, and customer brand attachment were positively influenced by brand equity. The level of customer brand attachment affected brand trust and online purchase intent in a positive way. An increase in brand trust led to a significant increase in online purchase intentions. An online purchase intention, customer brand attachment, and brand trust of a brand were influenced positively by brand equity during social media marketing. Social media marketing impacted online purchase intentions positively and significantly through customer brand attachment. Social media marketing improved online purchase intentions when brand trust is positive and significant. Several factors contributed to the effect of social media marketing on online purchase intentions, including brand trust. This leads us to conclude that social media marketing enhances online purchase intent through the creation of brand attachments, brand trust, and brand equity among customers.
Analysis of changes in HRD research topics before and after COVID-19 using keyword network analysis and topic modeling
Authors:   Human Engagement Institute, Jun Yoojin , Cho Daeyeon
Published: April 2023

The purpose of this study is to examine changes in research topics in major domestic HRD journals before and after COVID-19. To this end, a total of 710 papers from 2017 to 2022 were divided into pre-COVID-19 (2017-2019) and COVID-19 periods (2020-2022). Log odds ratio analysis, keywords network analysis, and topic modeling analysis were conducted,and the results of the study are as follows: First, the core keywords of research before COVID-19 were ‘knowledge,’ ‘career development,’ ‘innovation,’ ‘cooperation,’ and ‘women.’Second, the core keywords of research in the COVID-19 period were ‘COVID-19,’ ‘employment,’ ‘job finding,’ and ‘organizational culture.’ Third, new topics and keywords emerged in the COVID-19 period. 'Pandemic,' 'remote work,' 'job crafting,' and ‘online learning' were frequently used keywords in the period. Based on these results, changes in research topics in HRD journals related to COVID-19 were described. Academic and practicalimplications for the development of the HRD field in response to COVID-19 were also suggested.
Effectiveness of Pollinator Insects in Increasing Fruit Formation of Pummelo (Citrus maxima (Burm.) Merr.)
Authors: Atmowidi Tri , Cholis Muchamad Nur , Maulana Arif , Priawandiputra Windra , Kahono Sih
Published: April 2023

Pummelo (Citrus maxima (Burm.) Merr.) is a type of plant which have commercial value, and at least 24 cultivars are spread across various regions in Indonesia. Some cultivars have self-incompatibility (SI) mechanisms as genetic barriers to fertilization, but this can be reduced through cross-pollination by insects. Therefore, this study aims to measure the effectiveness of wild pollinator insects, as well as human and bee pollinations in pummelo. A total of six treatments were set up, namely closed pollination or control, open treatment, human pollination using pollen from the same tree (geitonogamy) or different trees (xenogamy), as well as supplementation colony of honey bee (Apis cerana), and stingless bee (Tetragonula laeviceps). The highest increase of pummelo fruit formation was found in human-pollination (xenogamy), followed by A. cerana, T. laeviceps, open treatment, and geitonogamy pollination with 63%, 54%, 48%, 41%, and 14%, respectively. Based on the results, bees (A. cerana, T. laeviceps, Ceratina sp., Xylocopa confusa, X. latipes), fly (syrphid species), as well as butterflies (Papilio demoleus, Catopsilia pyranthe, and C. pomona) are potential pollinating agents of pummelo
A organização curricular por situação de estudo
Authors: Rosa de Avila de Vasconcelos Andréia , Ritter Jaqueline
Published: April 2023

Instiga-nos compreender quais critérios são adotados por professores/pesquisadores na elaboração e desenvolvimento de uma proposta curricular por Situação de Estudo (SE). Para isso, realizou-se uma pesquisa de natureza qualitativa, mediante uma entrevista não-estruturada com o idealizador da SE. A entrevista, gravada em áudio, transcrita e analisada por meio da Análise Textual Discursiva, orientou-se pela seguinte questão norteadora: Como surgiu a proposta de SE? Com a experiência que você tem e teve nessa caminhada de estudos e pesquisas com a SE, quais são os principais critérios considerados na sua elaboração e desenvolvimento? Muito mais do que critérios de escolha de temas e conceitos, percebeu-se que há condições favoráveis que mediaram essas escolhas e que podem ou não influenciar o seu melhor êxito. Igualmente, as condições contextuais e normativas que permearam a origem dessa proposta de SE, que coincide com o lançamento dos PCNs, também evidenciam o quão difícil é organizar, de forma contextualizada, o currículo de Ciências nas etapas finais da Educação Básica, e desenvolver, na prática, um ensino com características efetivamente interdisciplinares.
El programa SARE anfibios: fortalezas y debilidades
Authors: Ayllón Enrique
Published: April 2023

En este trabajo se repasa la evolución del programa de Seguimiento de anfibios y reptiles de España (SARE) en el grupo de los anfibios, y se expone las posibles fortalezas y debilidades asociadas a la utilización de una metodología enfocada a la ciencia ciudadana, y más en detalle la ejecución de los muestreos, su calidad y la de los datos obtenidos con ellos.
Application of statistical and geostatistical approaches in temporal and spatial estimations of rainfall
Authors: Karami Hojat , Ghazvinian Hamidreza , Dadrasajirlou Yashar
Published: April 2023

This study is the first study that worked on the temporal and spatial distributions of annual rainfall (Pyear) and maximum 24-h rainfall (Pmax24h) in the Semnan province. For this purpose, different statistical distributions were used to estimate the temporal Pyear and Pmax24h in the Semnan province. Six synoptic stations across the province were studied and all stations had complete Pyear and Pmax24h data. Different return periods were studied. The goodness fit test of statistical distributions for Pyear showed that about 67% of the stations follow the Generalized Pareto (GP) distribution. Considering the Pmax24h, 50% of the stations follow the GP distribution, and for the ratio of Pmax24h to Pyear, 50% of stations follow the Generalized Extreme Value (GEV) distribution. The spatial distribution of Pyear and Pmax24h showed that in all return periods, by moving to the southeast of the province, precipitation amounts decreased. While moving toward the Shahmirzad station, the amounts of Pyear and Pmax24h increased. Also, there was a logical relationship between the Pyear and Pmax24h. Consequently, the minimum value and the maximum value of the R2 coefficient in different return periods were equal to 0.992 and 0.980, respectively.
O debate sobre a regulamentação jurídica dos partidos políticos na assembleia constituinte italiana (1946-1948)
Authors: Kristal Moreira Gouveia
Published: April 2023

O presente artigo analisa os debates transcorridos no processo constituinte italiano que geraram o art. 49 da Constituição Italiana de 1948 e os embates sobre a regulamentação dos partidos políticos, assim como as concepções de democracia que buscaram espaço na tensão entre “controle” e “flexibilidade” que pautou o posicionamento dos constituintes. Objetiva, com isso, analisar quais os argumentos contra e a favor de um controle constitucional sobre a formação e finalidade dos partidos políticos, assim como o conteúdo teórico sobre o conceito de democracia que pautou as discussões. Essa finalizada será alcançada a partir de pesquisa histórica utilizando-se como fontes as atas da Assembleia Constituinte Italiana e produção bibliográfica a respeito.
Literature review: nutrition supplementation for muscle fatigue in athletes
Authors: Mardiana Mardiana , Kartini Apoina , Sutiningsih Dwi , Suroto Suroto , Muhtar Muhammad Solihuddin
Published: April 2023

The use of natural or conventional-based supplementation has become a popular strategy among athletes seeking to reduce oxidative stress, improve recovery, and enhance athletic performance. This literature review searched four reputable international electronic databases, including PubMed, MedRxiv, Cochrane, and Clinical Trial.gov until December 2021, using Boolean operators with keywords and Mesh methods. The keywords used were "Supplementation", AND "Muscle Fatigue Recovery", AND "Athletes", which yielded 24 articles as study findings. The literature review found that exhaustive exercise can induce a neutrophil antioxidant response by increasing antioxidant enzymes. Nutritional supplements, specifically antioxidant supplements, Branched Chain Amino Acid (BCAA), citrulline, omega-3, and caffeine, have been scientifically proven to reduce oxidative damage, which can block signaling pathways related to muscle hypertrophy. In order to combat muscle fatigue in athletes based on this research (literature review), natural ingredients and synthetic nutritional supplements have been utilized as dietary interventions. This literature review identified numerous natural micronutrients and synthetic supplements used in sports that possess anti-fatigue properties, decrease oxidative stress and enhance athletes' endurance capacity. The effectiveness of nutritional supplements in addressing muscle fatigue may vary based on the various ingredients in the supplements. However, natural-based supplements have become a preferred option among athletes and coaches currently.
The effectiveness of Lombok traditional games on increasing physical literacy of elementary school
Authors: Sudarwo Raden , Kurniawan Edi , Irmansyah Johan , Mujriah Mujriah , Esse Balkis Ratu NL
Published: April 2023

Physical literacy has four components, one of which is the physical component. Increasing the physical component requires learning strategies implemented through physical education, one of which is the traditional Lombok game, which is an effective learning process for children. This research aims to test the effectiveness of traditional Lombok games in increasing physical literacy in elementary school students. This study used the Quasi Experimental Design research method (pretest and posttest control group design) involving 66 class IV students. It consists of two groups, namely, the control group and the intervention group. The intervention group (n = 33; 50% boys and girls) received a weekly 60-minute Lombok traditional game session provided by a local instructor trained in child care, whereas the control group (n = 33; 50% boys and women) received no additional treatment.Components of children's physical literacy were assessed using the PLAYbasic instrument before and after treatment. The results of the PL assessment of the pre-test control group were 42.7 in the Emarging category, the post-test was 45.5 in the Emarging category, while in the experimental group the pre-test was 45.6 in the Emarging category and the post-test was 65.1 in the Competent category, there was an increase in the experimental group. The experimental group using traditional Lombok games had a better level of physical literacy or the Competent category than the control group. While the results of data analysis from the study showed the output of the Independent Samples Test, the Sig value was obtained. (2-tailed) = 0.000 0.05.Thus, the traditional Lombok games for grade IV students aged 9 years have a significant influence. Based on these results, it shows the importance of traditional Lombok game interventions that can provide benefits for developing and increasing appropriate physical literacy in later life.
The effect of climbing and descending stairs varies in improving balestra fencing floret/foil weapon type
Authors: Amahoru Musfira , Mahyudin Reza , Samudro Touvan , Dahlan Firmansyah , Idha Takbiratul
Published: April 2023

Fencing is a sport that requires a maximum physical component so that in this study the aim was to test and find out the effect of variations in stair climbing exercises in improving floret/foil balestra fencing weapons. This study used a test-experiment with the research design "Single-Group Pretest-Posttest Design". The research sample consisted of 20 people, coming from students (elective course (MKP) Fencing) of a state university in eastern Indonesia (male and female) who were then divided into training groups through random sampling technique. The balestra fence measurement tool for floret/foil type weapons uses the Kuhadja fencing skills test. Pretest and posttest results were analyzed using the influence test (t-test). The research location is at the Football Stadium (a stadium grandstand with 25 steps). Results; 1) there was a significant difference between the pretest and posttest groups with the various stair climbing exercises towards increasing the ability to balestra floret fencing weapons. 2) There is a significant difference between the posttest (after treatment) of varied stair climbing training and the control group in increasing the ability to balestra floret fencing weapons. We estimate that this increase is the result of increased leg muscle strength, speed, and explosive power obtained through varied stair climbing exercises.
Use of Digital Health Technology Among Older Adults With Cancer in the United States: Findings From a National Longitudinal Cohort Study (2015-2021)
Authors: Zhou Weijiao , Cho Youmin , Shang Shaomei , Jiang Yun
Published: April 2023

Background

Despite the benefits of digital health technology use, older adults with cancer (ie, aged 65 years) have reported challenges to technology adoption. However, there has been a lack of a good understanding of their digital health technology use patterns and the associated influential factors in the past few years.

Objective

This study aimed to examine the trends in and factors associated with digital health technology use among older adults with cancer.

Methods

The National Health and Aging Trends Study (NHATS) data set is a national longitudinal cohort study with annual survey waves of Medicare beneficiaries 65 years and older. Participants were community-dwelling older adults who self-reported previous or current cancer diagnoses in each round. The study sample size of each round ranged from 1996 (2015) to 1131 (2021). Digital health technology use was defined as using the internet or online in the last month to order or refill prescriptions, contact medical providers, handle Medicare or other insurance matters, or get information about their health conditions. The association of sociodemographics, clinical factors (self-rated health, chronic conditions, difficulties in activities of daily living, dementia, anxiety, and depression), and physical function (Short Physical Performance Battery and grip strength) with digital health technology use was examined using design-based logistic regression. All statistical analyses accounted for the complex sample design.

Results

The prevalence of any digital health technology use increased from 36% in 2015 to 45% in 2019. In 2020-2021, which was amid the COVID-19 pandemic, it ranged from 51% to 52%. In terms of each digital health technology use behavior, in 2015, overall, 28% of older cancer survivors used digital health technology to obtain health information, followed by contacting clinicians (19%), filling prescriptions (14%), and handling insurance (11%). Greater use of digital health technology was associated with younger age, being White, having a college or higher education, having a higher income, having more comorbidities, nondementia, and having a higher gait speed.

Conclusions

Digital health technology use in older adults with cancer has gradually increased, particularly during the COVID-19 pandemic. However, socioeconomic and racial disparities have remained in older cancer survivors. Additionally, older adults with cancer may have some unique features associated with digital health technology use; for example, their use of digital health may be increased by their comorbidities (ie, health care needs) and reduced by their frailty.
Implementation Cascade of a Social Network–Based HIV Self-testing Approach for Men Who Have Sex With Men: Cross-sectional Study (Preprint)
Authors: Kwan Tsz Ho , Chan Denise Pui Chung , Wong Samuel Yeung-shan , Lee Shui Shan
Published: April 2023

BACKGROUND

HIV testing is the cornerstone of strategies for achieving the fast-track target to end the AIDS epidemic by 2030. Self-testing has been proven to be an effective health intervention for men who have sex with men (MSM). While social network–based approaches for distributing HIV self-tests are recommended by the World Health Organization, their implementation consists of multiple steps that need to be properly evaluated.

OBJECTIVE

This study aimed to assess the implementation cascade of a social network–based HIV self-test approach for reaching MSM who had never undergone testing in Hong Kong.

METHODS

This is a cross-sectional study. Seed MSM participants were recruited through different web-based channels, who in turn invited their peers to participate in this study. A web-based platform was set up to support the recruitment and referral process. Participants could request for an oral fluid or a finger-prick HIV self-test, with or without real-time support, after completing a self-administered questionnaire. Referrals could be made upon uploading the test result and passing the web-based training. Characteristics of participants completing each of these steps and their preferences for the type of HIV self-test were evaluated.

RESULTS

A total of 463 MSM were recruited, including 150 seeds. Participants recruited by seeds were less likely to have previously been tested for HIV (odds ratio [OR] 1.80, 95% CI 1.06-3.04, P=.03) and have lower confidence in performing self-tests (OR 0.66, 95% CI 0.45-0.99, P=.045). Almost all (434/442, 98%) MSM who completed the questionnaire requested a self-test, of whom 82% (354/434) had uploaded their test results. Participants requesting support were new to self-testing (OR 3.65, 95% CI 2.10-6.35, P<.001) and less confident in carrying out the self-test correctly (OR 0.35, 95% CI 0.22-0.56, P<.001). More than half (216/354, 61%) of the eligible participants initiated the referral process by attempting the web-based training with a passing rate of 93% (200/216). They were more likely to have sought sex partners (OR 2.20, 95% CI 1.14-4.25, P=.02), especially through location-based networking apps (OR 2.13, 95% CI 1.31-3.49, P=.002). They also gave higher usability scores along the implementation cascade (median 81 vs 75, P=.003).

CONCLUSIONS

The social network approach was effective in diffusing HIV self-tests in the MSM community and reaching nontesters. Support and option to choose a preferable type of self-test are essential to address users’ individual needs when delivering HIV self-tests. A positive user experience throughout the processes along the implementation cascade is vital to transform a tester into a promoter.

CLINICALTRIAL

ClinicalTrials.gov NCT04379206; https://clinicaltrials.gov/ct2/show/NCT04379206
Suicide Prediction from Social Media Data- Systemic Review Study (Preprint)
Authors: Rashid Soron Tanjir , Pagliari Claudia
Published: April 2023

BACKGROUND

Timely prediction and appropriate intervention can prevent suicide. However, suicide prediction has long been a major public health challenge and researcher explored different innovative approaches to find out a cost effective and efficient prediction system that can be scaled up to reduce the burden. Social media opened new horizon of research to monitor the behavior and activities of person in different context and observe expression and interaction at their own environments. The opportunity to monitor of large number of people at their natural environment made Social Media such as Twitter, Facebook, Weibo an important area of research for suicide prediction. Several studies have been reported those used different methods to develop suicide prediction system from social media data. However, it is still unclear whether social media can predict completed suicide from social media data through a systematized literature search.

OBJECTIVE

This study aimed to conduct a systematic search to find out common method of suicide prediction from social media data and to what extend social media data can predict completed suicides.

METHODS

A systemic search was conducted in multiple databases, grey literature including conference proceeding and clinical trial register from inception to 25th July 2019 following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-2009 guideline.
Snowball searching from the reference lists of included papers and personal communication with few potential authors were made to ensure maximum number of updated papers. Two researchers conducted the initial literature search independently following the predefined search strategies.

RESULTS

Of the 2955 papers screened, 15 were selected for the review which documented social media can predict suicide at individual or large population level by monitoring the frequency of posting, pattern of use of language, emotional expression on it. The social media-based suicide data corelated with regional, national or international suicide data.

CONCLUSIONS

Though social media-based suicide prediction documented promising result, their use in large scale suicide surveillance jeopardized by the ethical concern, quality of data and complex rapidly shifting digital ecosystem.
Exenatide for obesity in children and adolescents: Systematic Review and Meta-analysis (Preprint)
Authors: Li Xihong , Chen Bin , Xiao Dongqiong , Zou Zhuan , Zhang Xiaoyan
Published: April 2023

BACKGROUND

There is no curative treatment for childhood obesity.

OBJECTIVE

We aimed to synthesize published randomized controlled trials (RCTs) evidence on the efficacy of exenatide in obese children and adolescents.

METHODS

We searched and investigated all relevant studies in the PubMed, Web of Science, Embase, and Cochrane Library databases. Inclusion criteria were RCTs of exenatide for the treatment of obesity in children and adolescents. Primary outcomes were body weight, body mass index (BMI), fasting plasma glucose (FPG) or HbA1c change. Secondary outcomes were the occurrence of adverse events, especially hypoglycemia. The Cochrane bias assessment tool was used to assess the risk of bias in RCTs.

RESULTS

Five studies met the inclusion criteria. In total,100children were allocated to exenatide therapy. Compared with controls, exenatide therapy reduced body weight and BMI by −0.6%(95% CI −0.93,-0.27），−1.11%(95% CI −1.91,-0.31）， respectively. Adverse effects include gastrointestinal symptoms, the majority of these cases were mild in severity.

CONCLUSIONS

Exenatide is effective in treating obesity in children and adolescents.

CLINICALTRIAL

https://www.crd.york.ac.uk/prospero/, identifier CRD42023413706.
National Cultural Gene and Contemporary Value of Silver Jewelry of She Nationality from the Perspective of National Psychology
Authors: Zhang Yong
Published: April 2023

The purpose of this study is to deeply explore the national cultural gene and its contemporary value of She silver jewelry, and to provide theoretical basis and practical support for the inheritance, protection and innovation of national culture in eastern Fujian. At the same time, this study will also provide new perspectives and ideas for the study of minority cultures in China.
Hydroxyethylcellulose as a versatile viscosity modifier inthe development of sugar-free, elegant oral liquidformulations
Authors:   Ashland Private Limited, India, J Vijaya Kumar , Dantuluri Ajay Kumar ,   Ashland Private Limited, India, Liu Yi ,   Ashland (China) Holdings Co., Ltd., China, Durig Thomas ,   Ashland Specialty Ingredients, Wilmington, DE, USA
Published: April 2023

Pharmaceutical formulations in liquid form for oral administration are commonly utilized for geriatric and pediatricpatients who have difficulty swallowing solid dosage forms. Rheology, texture, and stability are among the Critical Quality Attributes (CQAs) that must be addressed in the development of oral liquid dosage forms. The distribution of pharmaceutical components relies on the manipulation of rheological properties and stabilization within these forms. The utilization of thickening agents to increase the viscosity of the liquid vehicle serves to reduce particle settling. Historically, sugars such as sucrose were utilized for this purpose, as well as for masking the taste of activepharmaceutical ingredients (API). However, alternative thickening agents such as xanthan gum, tragacanth, carrageenan, and cellulose derivatives (such as sodium carboxymethylcellulose, methylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose and hydroxyethylcellulose etc.) are increasingly employed asthey do not possess the same risks of glycogenic and cariogenic as sugars. Cellulose derivatives, due to their water binding and viscosity modifying properties, can be effectively utilized to enhance the rheological properties andstability of oral liquid dosage forms. The use of hydroxyethylcellulose, a highly water-soluble cellulose ether polymer, as a viscosity modifying agent, as well as its underlying polymer chemistry, is thoroughly examined in thisliterature review. Keywords: Cellulose Derivatives; hydroxyethylcellulose; oral Liquids; Natrosol™ 250 HEC, syrup
ANÁLISE DOS IMPACTOS DA PENETRAÇÃO DA GERAÇÃO DISTRIBUÍDA NA REDE DE DISTRIBUIÇÃO RELACIONADOS AO SISTEMA DE COMPENSAÇÃO BRASILEIRO
Authors: Silva Tiago Argollo , Guerrieri Daduí Cordeiro
Published: April 2023

A crescente demanda mundial por energia elétrica associada ao aumento das emissões de gases de efeito estufa está resultando em uma necessidade crescente de uso de energia limpa. A energia solar é uma das soluções de energia limpa que vem crescendo e se consolidando ao redor do mundo. No Brasil, para incentivar o uso da energia solar, o governo habilitou e estimulou o setor de Geração Distribuída por meio da Resolução Normativa 482/2012. Porém, o crescimento da Geração Distribuída está impactando à rede de distribuição. Por conta disso, os órgãos responsáveis pelo planejamento energético no Brasil estão propondo alterações a atual resolução. Nesse contexto, este trabalho tem como objetivo discutir os impactos na redução de receita causados pela penetração da Geração Distribuída na rede de distribuição, onde são analisadas as dez principais distribuidoras brasileiras de energia. Para tanto, é realizada pesquisa documental por meio de bancos de dados, leis e regulamentos. Além disso, é proposto um método para quantificar a taxa de penetração da Geração Distribuída e seu impacto nas redes de distribuição. Os resultados apresentam as taxas de penetração da Geração Distribuída nas redes de distribuição e o impacto quantificado da Geração Distribuída, em kWh, na distribuidora. Apresenta também indicadores que podem auxiliar os gestores do setor de energia a formular e/ou criar estratégias para solucionar os impactos negativos da penetração da Geração Distribuída na rede de distribuição.
Design and Development of R32a and HFO-1234yf Refrigeration blend in Air conditioning System
Authors: Gupta Abhishek S. , Bhosale Kartik S. , Ahmed Mohd Aman , Rawoot Zuheb , Ware Prof. Dhanashree
Published: April 2023

Abstract: Refrigeration and air-conditioning systems become an integral part of modern society. Electricity-driven vapour compression systems have been dominating the heating, ventilation, air conditioning and refrigeration (HVAC&R) industry. The working fluids of these systems often contribute to the environmental issues in the forms of direct and indirection emissions. Pure refrigerants are often limited inmeeting criteria such as efficiency, flammability, toxicity, and compatibility. Meanwhile, refrigerant mixtures offer flexibilities to tune these criteria, This paper will review the status worldwide on technical and policy search for next-generation refrigerants with both low Global Warming Potential (LGWP) and low Life Cycle Climate Performance (LCCP) with particular focus on R410A replacement for unitary A/C & H/P. R32 and the HFO blends offer potential solutionsbut all involve tradeoffs among Global Warming Potential (GWP), efficiency, safety, and cost. With the U.S. mandating new higher regional efficiency standard taking effect January 2015, there is even more pressure in finding a LowGWP refrigerant solution that is affordable and can sustain efficiency and reduce charge requirement. This paper focuses more on R32 as the available data for HFO blends is limited. And Mixing of both R32a and HFO-1234yf in Ac To Study the performance two different next generation refrigerants R32 and Hfo-1234yf.To determine most promising refrigerant blend for air conditioning system test observe, anaylize and compare result obtained with conventional refrigerant. To determine impact of R32 and HFO-1234yf refrigerant as a replacement of R410A
An Efficient, Optimized and Solar Based Automatic Irrigation System using GSM Module
Authors: Ueeke Ritik , Dhamgaye Palay , Ghyar Suraj , Sirsikar Rakesh , Punyapawar Pranay , Agrawal Prof. Dr. G.H.
Published: April 2023

Abstract: The automatic solar-based irrigation system using a GSM modem is a novel solution to address the challenges faced by farmers in ensuring efficient use of water resources for crop cultivation. This system utilizes solar energy to power a water pump, which is controlled by a microcontroller. The GSM modem enables remote monitoring and control of the system, allowing farmers to receive real-time updates on the status of the irrigation system and make necessary adjustments as needed. The system also includes sensors to measure soil moisture levels and control the irrigation based on the crop water requirements, thus ensuring optimal water usage. This paper presents the design, development, and testing of the automatic solar-based irrigation system using a GSM modem, highlighting its potential to increase crop yields while conserving water resources.
Sighted-Helmet Detection and E-Challan Application
Authors: Mahajan Ritesh , Patil Anish , Sandhu Saheb Singh , Telang Om , Samudre Niranjan
Published: April 2023

Abstract: Helmet detection is a technology that uses computer vision algorithms to automatically detect and identify individuals who are not wearing helmets while riding a two-wheeled vehicle. This technology is often used in conjunction with e-challan systems, which are electronic systems for issuing traffic violations and fines. By combining helmet detection with e-challan, law enforcement officials can more effectively enforce helmet laws and reduce the number of injuries and deaths caused by head injuries in motorcycle accidents. The technology can be used in various forms like CCTV cameras, drones, etc. The Helmet detection algorithm uses deep learning techniques like CNN, YOLOv8 etc to detect and classify the helmets in real-time video feed. We have developed an application “Sighted”, which is used to track the current active challans issued in the name of the owner and easy payment of the fines. The main objective of the system is to identify riders without helmet and issue a challan with an application providing services to track the challan status and payment.
NGS and Sequence Analysis with Biopython for Prospective Brain Cancer Therapeutic Studies
Authors: Kumari Uma , Gupta Shruti
Published: April 2023

Abstract: Malignant primary brain tumour in adults and in analysis driven by variousgenomic alterations. Next generation sequencing (NGS) provides about the geneticlandscape of tumours and might detect targetable mutations. Genomic DNA wasextracted from blood samples or tumor tissues number of biological pathways incancer involve the products of genes that are not mutated, but epigenetically whenwe found regulated, for example by altered transcription factor availability,repressor activity or gene methylation receptor-type protein tyrosine phosphatases(RPTPs) comprises PTPRZ and PTPRG,primary human glioblastomas suggested aclose association between PTPRZ1 (human PTPRZ) expression and cancerstemness. The functional roles of PTPRZ activity in glioma that sphere-forming cellsin human U251 glioblastoma cell lines showed high expression levels of PTPRZ-B.Potential PTPRZ1-MET fusion, that is caused when PTPRZ1 and the MET oncogene are fused in 8% to 16% of gliomas and is linked to a less favorable outcome nevertheless is also a promising biomarker for kinase inhibitor therapy. In accordance to the studies that are currently available, receptor-type tyrosine-protein phosphatase zeta (PTPRZ1) is found in various tumour tissues and plays a role in migration, cell proliferation, the EMT and adhesions, as well as treatment resistance by binding with a variety of substances.
Design and Fabrication of Imprint Machine
Authors: Mehar Pundlik G. , Deshpande Rushikesh , Pandhare Ritesh , Sawaithul Shantanu , Kawale Yash
Published: April 2023

Abstract: This Research Paper aimed at automating the process of marking serial numbers or identification codes on metal, wood, plastic components. This Machine accurately punch numbers onto metal, wood, plastic parts with varying sizes and thicknesses. The machine's design includes a robust frame, a pneumatic system, and a control system that allows for precise control of the number punching process. The punching mechanism consists of a series of hardened steel punches that can be easily replaced and adjusted to accommodate different numbers and character sizes. The control system allows operators to input the desired serial number or identification code, control the punching force, and regulate the individual spacing. The machine also includes safety to prevent injury to operators and damage to the metal parts. Overall, the design and fabrication of a imprint machine for metal parts will provide an innovative solution for manufacturers looking to streamline their product identification process.
LPG Gas Leakage Detection and Alert System
Authors: Dharaskar Bhagyashree , Gaigawali Alkesh , Meshram Sahil , Tembhurne Ayush , Gautam Abhishek , Nanhe Aman
Published: April 2023

Abstract: This project proposes designing and implementing an LPG gas leakage detection and alert system for households and industries. The increase in deaths caused by LPG explosions has highlighted the need for a gas leak detection system to identify potential hazards. Various gas sensors are used in this process, including wireless and GSM technology. The gas sensor detects the presence of LPG gas in the environment, and the microcontroller processes the sensor data to trigger an alarm or shut off the gas supply. The system can also send an SMS alert to a designated phone number in case of gas leakage. The proposed system is intended to prevent accidents, fires, and explosions by providing an early warning and taking necessary actions to minimize the damage caused by gas leakage. The proposed LPG Gas Leak Detection Smart Tool effectively addresses the growing concern about LPG explosions and their catastrophic consequences.