bluuebunny/crossref_metadata_2025 huggingface dataset:
Identifying the phases of learning in an Australasian undergraduate architecture design studio model
Authors: Iftikhar Naima , Crowther Philip , Burton Lindy Osborne
Published: February 2023

An understanding of the theoretical basis of the design learning process, and the resulting partnership between students and teachers in contemporary design studios, is required to optimise learning. Students’ learning in the architecture design studio has been widely studied, however the specific activities of students and teachers, and the interpersonal interactions between them, have not been investigated in great depth. This research identifies a complex, nuanced situation, one with three consecutive phases of different learning activities and relationships. An undergraduate architecture program at a large Australian university is analysed using a modified Delphi method to investigate the perceptions of staff and students and achieve convergence upon a shared understanding of how the design learning process unfolds through three distinct phases to support learning.
Semi-Permanent Use of Indocyanine Green Latex Phantom for Fluorescence Emission
Authors: Kim Min Chan , Yoon Kicheol , Kim Kwang Gi
Published: February 2023

Introduction

Testing the fluorescence emission of the vascular circulation status of the indocyanine green (ICG) fluorescence contrast agent to validate the system performance is crucial. Hence, the development of an ICG phantom is imperative, and this study proposes a method for manufacturing an ICG phantom.

Method

The ICG with an initial concentration was subjected to 0.2 cc sampling through syringe(x), and an ICG (0.2 cc) is diluted with silicon (Si) latex lubber (10 mL) during the manufactured the phantom. The brightest fluorescence expression state is 30 μM, and if it exceeded 50 μM, fluorescence fading occurred and changed to a dark color.

Results

The liquid (ICG) of the concentration range is 0.003 mM to 0.24 mM, and the maximum fluorescence expression range is 0.005 to 0.006 mM when the phantom is irradiated using a 780-nm (800 mW) LED. In addition, the fluorescence emission is reduced to 0.24 mM, and the fluorescence expression concentration is 10 μM, 30 μM, and 50 μM, respectively. The decreasing of the fluorescence emission is beginning to 50 μM.

Conclusions

In this study, the proposed phantom with ICG fluorescence emission using latex lubber is proposed. In this works, the proposed phantom is improved the performance for ICG fluorescence emission. In the manufactured phantom, the phantom is used for gelatin, and the advance of phantom has easy manufacturing and long-life fluorescence emission (semipermanent) due to incorrodible material (latex lubber). To experimental results of a phantom, the ICG fluorescent contrast medium (0.055 mM) is same to 30 μM. Then, the 0.055 mM and 30 μM have high resolution and fluorescence emission status. Thus, the results are in good agreement.
Screenshotting What’s Important in Video Data: An Experiment in Collaborative, Subjective Analysis of Artifactual, Cultural Research with Children
Authors: Collier Diane R. , Kaur Simranjeet , McKinney-Lepp Melissa , Rondinelli Zachary J.
Published: February 2023

When using video and visual methods in qualitative and post-qualitative research, the size and scale of the data set can be overwhelming, particularly for new researchers. Collaborative research teams often work with a code book to systematize and unify their analyses. Interpretive researchers pursuing multi-layered and multi-voiced visual analysis often find it difficult to move away from desires for a single ‘best’ interpretation of what happened. This paper illustrates and interrogates an open and flexible method for ‘thinning’ (screenshotting) video data that we call the ‘Five Images Method’. We offer one unfolding of interpretive processes and tensions and examine how four researchers worked across positionalities to analyse video data. We start with our positionalities in relation to a research study of children creating photographic and written stories of cultural artifacts, carried out over one year. The primary data from the study was generated through online video-conference sessions connecting a university researcher with an elementary class. A second level of data was created through a process of screenshotting, followed by recursive cycles of conversation about the choices of each researcher, and how they were guided by background, geography, roles in relation to child participants, technologies, personal experiences, and so on. Two key incidents that illustrate the potential of the method and the interpretations produced are described. We argue that reducing video data in this way can be both generative and limiting, while also serving as a catalyst for enhanced analysis. The collaborations and relationships built in research teams through slow processes of analysis (and writing!) working across difference also promote evocative and layered learning. Looking at interpretations as multiple can be hampered by longstanding histories of research as intended to produce authentic and singular truths.
A Daoist understanding of mindful leadership
Authors: Tan Charlene
Published: February 2023

This article seeks to contribute to the discourse on mindful leadership by drawing on Daoist philosophy as recorded in the Daodejing (Book on the Way and Virtue). Without a clear articulation of its normative underpinnings, mindful leadership can be easily exploited by leaders for immoral agendas and outcomes. The existing literature describes Daoist leadership as antithetical to autocratic leadership, and is unimposing and ethical. Giving additional insights to the construct of Daoist leadership, this essay argues that a Daoist leader exemplifies dao (Way-making) and wuwei (noncoercive action). Way-making is about influencing followers towards a common goal through the leader’s de (virtue). In addition, a Daoist leader promotes wuwei by enacting non-interfering, inspiring, liberating and nurturing management practices. Daoist principles provide an ethical foundation of mindful leadership by replacing McMindfulness with attentiveness to moral virtues. By foregrounding the centrality of ethics in leadership, this study seeks to open a line of inquiry and raise thought-provoking questions on the normative basis of mindful leadership.
Four Misconceptions About Nonverbal Communication
Authors: Patterson Miles L. , Fridlund Alan J. , Crivelli Carlos
Published: February 2023

Research and theory in nonverbal communication have made great advances toward understanding the patterns and functions of nonverbal behavior in social settings. Progress has been hindered, we argue, by presumptions about nonverbal behavior that follow from both received wisdom and faulty evidence. In this article, we document four persistent misconceptions about nonverbal communication—namely, that people communicate using decodable body language; that they have a stable personal space by which they regulate contact with others; that they express emotion using universal, evolved, iconic, categorical facial expressions; and that they can deceive and detect deception, using dependable telltale clues. We show how these misconceptions permeate research as well as the practices of popular behavior experts, with consequences that extend from intimate relationships to the boardroom and courtroom and even to the arena of international security. Notwithstanding these misconceptions, existing frameworks of nonverbal communication are being challenged by more comprehensive systems approaches and by virtual technologies that ambiguate the roles and identities of interactants and the contexts of interaction.
Sleep hygiene education for improving sleep in ultra-marathon swimmers: Guidance for coaches and swimmers
Authors: Dunican Ian C , Perry Emma , Maisey Gemma , Nesci Elena , Roberts Spencer
Published: February 2023

Sleep for recovery is an essential factor for performance in athletes. One such group is recreational ultra-marathon swimmers (>10km). We aimed to compare measures of sleep before and after a sleep hygiene education intervention during a 16-week training programme. Using a prospective study design, the experiment was conducted in two phases (pre- and post-intervention), whereby pre- and post-intervention data were collected for 42 nights after the sleep hygiene education. This study had 24 masters’ swimmers (n = 13 females), aged 39 ± 11 years, and body mass index (BMI) of 26 ± 3 kg/m2 during a training squad for an ocean ultra-marathon swimmer (19.7 km) in Perth, Western Australia. Objective measures of sleep were obtained from a wrist activity monitor, the Readiband™ (Fatigue Science Inc., Canada). Participants underwent a 2-hour sleep hygiene education session. Generalised linear mixed models were fitted to examine relationships between predictor variables and sleep responses. Sleep onset and offset increased by 12 minutes post-intervention ( p < 0.001). For nights before morning training, sleep onset increased by 12 minutes and offset by 24  minutes post-intervention. Females increased sleep onset by 18 minutes and delayed sleep offset by 12 minutes sleep ( p < 0.05) post-intervention. The sleep hygiene education was insufficient in making meaningful improvements to measures of sleep. Individual sleep hygiene education and continuous reinforcement of sleep for recovery during a training programme may be required to observe improvements. Coaches should aim to design training schedules to minimise the impact on swimmer’s sleep opportunity and swimmers need to involve family in the planning of rest periods during a training programme.
Cut-off values of internal rotation in the glenohumeral joint for functional tasks in children with brachial plexus birth injury
Authors: Delioğlu Kıvanç , Uzumcugil Akin , Öztürk Ebru , Bıyık Kubra Seyhan , Ozal Cemil , Gunel Mintaze Kerem
Published: February 2023

The aim of this study was to determine the cut-off values of the range of internal rotation motion in the isolated glenohumeral joint that is required for functional tasks in children with an upper root injury of the brachial plexus. Internal rotation motion was measured using a universal goniometer in 97 participants. The Mallet Hand to Spine and Mallet Hand to Belly tasks were assessed as functional tasks that require internal rotation of the shoulder. For the Hand to Spine task, 41° passive and 30° active internal rotation were necessary to reach the S1 level. For the Hand to Belly task, 42° passive and 29° active internal rotation were required to place the palm on the belly without wrist flexion. Of our participants, 97% could touch the belly with or without wrist flexion, but 28% could not reach S1 in the Hand to Spine task. The results of this study show the necessary amount of internal rotation of the shoulder that should be considered in treatment strategies.

Level of evidence: III
Relationship between the prosthesis scapular neck angle and clinical outcomes in reverse shoulder arthroplasty
Authors: Zino Kuhn M , Hao Kevin A , Cueto Robert J , Dean Ethan W , King Joseph J , Schoch Bradley S , Wright Jonathan O , Farmer Kevin W , Struk Aimee M , Wright Thomas W
Published: February 2023

Background

Optimal glenosphere positioning in reverse shoulder arthroplasty (RSA) remains highly debated. We aimed to characterize the association between the prosthesis scapular neck angle (PSNA) and postoperative range of motion (ROM) and clinical outcome scores.

Methods

A retrospective review of 284 RSAs using a single design with minimum 2-year follow-up was performed. Glenosphere tilt was measured postoperatively using PSNA. ROM and functional outcome scores were assessed preoperatively and at latest follow-up. The PSNA was dichotomized to inferior or superior groups (>90° vs ≤ 90°, respectively) and stratified into quartiles; ROM and outcome score measures were compared between groups controlling for inferior glenosphere overhang.

Results

No range of PSNA was consistently associated with superior ROM, clinical outcome scores, or rates of complications including scapular notching. However, greater preoperative to postoperative improvement in active FE was found for superiorly (PSNA ≤ 90°) versus inferiorly tilted glenospheres (37° ± 33° vs 53° ± 35°, P  =  0.005) and the greater improvement in active FE (57° ± 35°, P  =  0.004) was further isolated to the first quartile (mean 85.1° ± 3.5°).

Discussion

A lack of variation in clinical outcomes based on PSNA suggests negligible short-term (median follow-up 3.1 years) clinical significance when glenosphere tilt falls within the distribution of this cohort (mean 92.6° ± 6.2°).
Antimicrobial Natural Products Derived from Microorganisms Inhabiting the MENA Region
Authors: Awada Bassel , Chahine Dany Abi , Derbaj Ghada , Khalek Pascal Abdel , Awad Mireille Kallassy , Fayad Antoine Abou
Published: February 2023

Objective/Background

Natural products (NPs) derived from microorganisms are the basis of a plethora of clinically utilized medications, namely, antimicrobial remedies. Although these secondary metabolites have been extensively explored all over the planet, they remain understudied in the Middle East and North Africa (MENA) region.

Methods

A literature search was conducted to first find NPs that were isolated from environmental fungi and bacteria that inhabit the soils and seawater of the MENA region. Then, purified molecules with biological activity against pathogenic bacteria, biofilms, fungi, and parasites were described in terms of structure, function, and location. Moreover, the methods that could be used to ameliorate the discovery of novel NPs from this region were investigated.

Results

A multitude of antimicrobial molecules from various chemical classes were found to be derived from the environmental microbes of MENA. Although many were rediscovered, some represented novel structural scaffolds for novel families of antimicrobial agents. Additionally, the geographical distribution showed a high number of these NPs were unraveled in a restricted area leaving much of MENA untapped. Furthermore, as relatively traditional and low-efficiency methods were typically used in the discovery process, advanced high-throughput techniques were suggested to enhance this practice at the regional level.

Conclusion

MENA represents a fairly unexploited region where antimicrobial drug discovery could be performed comprehensively through the concomitant exploration of untouched geographical locations and advanced molecular techniques.
Changes in the Subchondral Bone Affect Pain in the Natural Course of Traumatic Articular Cartilage Defects
Authors: Kato Yuichi , Nakasa Tomoyuki , Sumii Junichi , Kanemitsu Munekazu , Ishikawa Masakazu , Miyaki Shigeru , Adachi Nobuo
Published: February 2023

Objective

Articular cartilage defect causes joint pain and finally progresses to osteoarthritis. Although the subchondral bone condition affects clinical outcomes of cartilage defects, the natural course of changes in subchondral bone and associated pain in full-thickness cartilage defects remain unknown. Therefore, we investigated the natural course of histological changes in subchondral bone and joint pain in cartilage defects using a rat model.

Design

Full-thickness cartilage defects were created at the medial femoral condyle of 10-week-old male Sprague-Dawley rats. Rats were sacrificed at 3, 7, 14, 28, and 56 days postoperatively, and histological including immunohistochemistry and tartrate-resistant acid phosphatase (TRAP) staining and micro-computed tomography (μCT) analyses of their knees were performed. Pain was evaluated using behavioral analysis and immunofluorescence staining of the dorsal root ganglion (DRG).

Results

The contour of the subchondral bone plate was maintained until day 3, but it was absorbed just under the cartilage defect from day 7 to 14. Starting on day 28, sclerotic changes surrounding the bone absorption area were detected. In the subchondral bone, the number of TRAP-positive cells peaked on day 14. Osteocalcin-positive cells were observed at 7 days, and their number gradually increased till day 56. Behavioral analysis showed that the total distance and the number of getting up by hind legs decreased on day 14. The number of calcitonin gene-related peptide-positive fibers in the DRG increased and was the highest on day 14.

Conclusions

The subchondral bone condition under cartilage defects dynamically changes from bone resorption to sclerosis and is related to pain level.
Climbing the Invisible Ladder: Attenuating Belief in Free Will Reduces Subjective Perceptions of Social Mobility
Authors: Seto Elizabeth
Published: February 2023

Can belief in free will alter our perceptions of social mobility? Five studies manipulated free will beliefs and assessed subjective individual social mobility (Study 1), subjective social status across time (Study 2), objective social class 10 years (Study 3) and 20 years (Study 4) into the future, and counterbalanced subjective and objective social mobility measures (Study 5). Challenging free will beliefs reduced subjective perceptions of upward mobility in Study 1 and led to lower perceptions of subjective social status in the distant, but not in near future in Study 2. Studies 3 and 4 found that threatening free will beliefs did not influence perceptions of future objective social class. Study 5 revealed that weakening free will beliefs affected subjective and objective social mobility, with the latter under specific boundary conditions. The differential effects of belief in free will on perceived social mobility are discussed.
Association between digital literacy, internet addiction, and cyberloafing among higher education students: A structural equation modeling
Authors: Arslantas Tugba Kamali , Yaylacı Muhammed Emre , Özkaya Mehmet
Published: February 2023

The current study aims to examine the association between digital literacy (DL), Internet addiction (IA) and cyberloafing (CL) levels of higher education students in Turkey. In addition, the study examined the correlation between “daily Internet use,” “initial Internet usage,” and “purpose of Internet use” with the variables of DL, IA, and CL. The study groups consisted of 1220 higher education students including all faculties and all grades of a state university. The “Digital Literacy Scale,” “Internet Addiction Scale,” and “Cyberloafing Scale” were used as data collection instruments. The study’s findings revealed initial Internet usage to be a predictor of DL, IA, and CL. Similarly, participants who spent more than 6 h using the Internet during a day have a higher level of DL, CL, and IA. Results from structural equation modeling reported a positive association between DL and IA, a negative association between DL and CL, and a positive relationship between IA and CL. Moreover, an indirect effect was revealed from DL to CL through IA. The study suggests improving students’ DL skills, as they form the basis of avoiding CL behavior, and using the Internet mostly for educational purposes.
Patient and provider perspectives to utilization of telemedicine in surgery
Authors: Mark John , Cooke David T , Suri Avni , Huynh Timothy T , Yoon Paul S , Humphries Misty D
Published: February 2023

Objectives

Determine patient and provider perspectives on widespread rapid telemedicine implementation, understand the key components of a surgical telemedicine visit and identify factors that affect future telemedicine use.

Summary of background data

Compared to other specialties, the field of surgery heretofore has had limited adoption of telemedicine. During the COVID-19 pandemic Healthcare, including the surgical specialties, saw new widespread use of telemedicine.

Methods

We conducted a prospective cohort study during the COVID-19 California stay-at-home and physical distancing executive orders. Utilization data were collected from clinics and compared to usage data during the same time 1 year later. All patients and providers who participated in a telemedicine visit during the study period were asked to complete a survey after each encounter and the surveys were analyzed for trends in opinions on future use by stakeholders.

Results

Over the 10-week period, the median percentage of telemedicine visits per clinic was 33% (17%–51%) which peaked 3 weeks into implementation. One hundred and ninety-one patients (48% women) with a median age of 64 years (IQR 53–73) completed the patient survey. Patients were first-time participants in telemedicine in 41% ( n = 79) of visits. Fifty-seven percent ( n = 45) of first-time users preferred that future visits be in-person versus 31% of prior users ( p = 0.007). The median travel time from home to the clinic was 40 min (IQR = 20–90). Patients with longer travel times were not more likely to use telemedicine in the future (61% with longer travel vs. 53% shorter, p = 0.11). From the 148 provider responses, 90% of the visits providers were able to create a definitive plan with the telemedicine visit. A physical exam was determined not to be needed in 45% of the visits. An attempt at any physical exam was not performed in 84% of routine follow-up or new-patient visits, compared to 53% of post-op visits ( p = 0.001).

Conclusion

Telemedicine is a viable ambulatory visit option for surgical specialists and their patients. During rapid telemedicine deployment, travel distance did not correlate with increased use of telemedicine, and in-person visits are still preferred. However, nearly half of all visits did not need a physical exam, which favors telemedicine use.
Ileocolic neoplastic intussusception—Imaging role and surgical management: A case report
Authors: Hadjidekov George , Neykov Dimitar
Published: February 2023

Intussusception refers to invagination of bowel loops into a neighboring, adjacent bowel segment. While it is not an uncommon entity in paediatrics—about 95% of intussusceptions occur in childhood, merely 5% of them affect the adult population. When affecting the later typically the small intestine is engaged rather than the colon. The diagnosis often represents with unspecific symptoms and is rarely considered a possibility in adults. In the past the diagnosis was typically made intraoperatively. As the Multi-Detector Computed Tomography (MDCT) of the abdomen became a referral diagnostic method, recognizing the signs of the condition is very important since some of the cases are transient, while others have an underlying malignant cause and more aggressive treatment is required. Surgical treatment planning is mandatory in those neoplastic complicated cases. The presented case report describes the role of radiology and the surgical treatment of a malignant ileocolic intussusception.
Effect of Vibrotactile Stimulation on Auditory Timbre Perception for Normal-Hearing Listeners and Cochlear-Implant Users
Authors: Verma Tushar , Aker Scott C. , Marozeau Jeremy
Published: February 2023

The study tests the hypothesis that vibrotactile stimulation can affect timbre perception. A multidimensional scaling experiment was conducted. Twenty listeners with normal hearing and nine cochlear implant users were asked to judge the dissimilarity of a set of synthetic sounds that varied in attack time and amplitude modulation depth. The listeners were simultaneously presented with vibrotactile stimuli, which varied also in attack time and amplitude modulation depth. The results showed that alterations to the temporal waveform of the tactile stimuli affected the listeners’ dissimilarity judgments of the audio. A three-dimensional analysis revealed evidence of crossmodal processing where the audio and tactile equivalents combined accounted for their dissimilarity judgments. For the normal-hearing listeners, 86% of the first dimension was explained by audio impulsiveness and 14% by tactile impulsiveness; 75% of the second dimension was explained by the audio roughness or fast amplitude modulation, while its tactile counterpart explained 25%. Interestingly, the third dimension revealed a combination of 43% of audio impulsiveness and 57% of tactile amplitude modulation. For the CI listeners, the first dimension was mostly accounted for by the tactile roughness and the second by the audio impulsiveness. This experiment shows that the perception of timbre can be affected by tactile input and could lead to the developing of new audio-tactile devices for people with hearing impairment.
High-Dose Aflibercept for Neovascular AMD and DME in Suboptimal Responders to Standard-Dose Aflibercept
Authors: Nielsen Jared S. , Roberts Carter L. , Saggau David D. , Alliman Kyle J.
Published: February 2023

Purpose: To assess the effect of higher dose (HD) aflibercept on visual acuity (VA), optical coherence tomography outcomes, and injection burden in eyes with neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME) that responded suboptimally to standard-dose aflibercept. Methods: This retrospective analysis included eyes with clinically significant disease activity on monthly therapy (AMT) (injection interval ≤35 days) or clinically significant increased activity on extension (IAE) (injection interval >36 days) that were switched from aflibercept 2 mg to aflibercept HD (3 mg to 4 mg). Outcomes were assessed at baseline, after injections 1 through 4, and at 6, 9, and 12 months. Results: Overall, 318 eyes of 288 adult patients were analyzed (eyes with nAMD: 59 AMT, 147 IAE; eyes with DME: 50 AMT, 62 IAE). Most of the study cohort received aflibercept HD 3 mg (nAMD: 73% AMT and 58% IAE; DME: 49% AMT and 68% IAE); the remainder received 4 mg. The mean best VA improved significantly with AMT and was maintained with IAE. In all groups, the central subfield thickness decreased significantly and the mean injection intervals increased or remained stable. No new safety signals were observed. Conclusions: Aflibercept HD might improve outcomes while decreasing treatment burden for eyes that respond suboptimally to standard dosing.
COVID-19 Supply Chain Risks and Environmental Impact Assessment
Authors: De Silva Q.S.M Titus
Published: February 2023

This article describes the risks and environmental impacts associated with COVID-19 supply chain activities from production of vaccines to the ultimate disposal of personal protective equipment (PPE). The benefits and harm to the environment arising from preventive measures such as lockdown, wearing masks, travel restrictions, and hand washing are described. Three tools are used in the evaluation: (a) evaluation of risks in the supply chain using failure modes and effects analysis (FMEA), (b) evaluation of risks due to social behavior, using the tool RIKA and (c) environmental impact assessment. Risk communication and risk mitigation strategies are described. COVID-19 presents us an ideal opportunity to learn from the benefits and adopt measures to minimize environmental harm.
AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats
Authors: Wang Hung-Chen , Cheng Kuang-I , Tseng Kuang-Yi , Kwan Aij-Lie , Chang Lin-Li
Published: February 2023

Background

Glycine receptors (GlyRs) play key roles in the processing of inflammatory pain. The use of adeno-associated virus (AAV) vectors for gene therapy in human clinical trials has shown promise, as AAV generally causes a very mild immune response and long-term gene transfer, and there have been no reports of disease. Therefore, we used AAV for GlyRα1/3 gene transfer in F11 neuron cells and into Sprague–Dawley (SD) rats to investigate the effects and roles of AAV-GlyRα1/3 on cell cytotoxicity and inflammatory response.

Methods

In vitro experiments were performed using plasmid adeno-associated virus (pAAV)-GlyRα1/3-transfected F11 neurons to investigate the effects of pAAV-GlyRα1/3 on cell cytotoxicity and the prostaglandin E2 (PGE2)-mediated inflammatory response. In vivo experiment, the association between GlyRα3 and inflammatory pain was analyzed in normal rats after AAV-GlyRα3 intrathecal injection and after complete Freund's adjuvant (CFA) intraplantar administration. Intrathecal AAV-GlyRα3 delivery into SD rats was evaluated in terms of its potential for alleviating CFA-induced inflammatory pain.

Results

The activation of mitogen-activated protein kinase (MAPK) inflammatory signaling and neuronal injury marker activating transcription factor 3 (ATF-3) were evaluated by western blotting and immunofluorescence; the level of cytokine expression was measured by ELISA. The results showed that pAAV/pAAV-GlyRα1/3 transfection into F11 cells did not significantly reduce cell viability or induce extracellular signal-regulated kinase (ERK) phosphorylation or ATF-3 activation. PGE2-induced ERK phosphorylation in F11 cells was repressed by the expression of pAAV-GlyRα3 and administration of an EP2 inhibitor, GlyRαs antagonist (strychnine), and a protein kinase C inhibitor. Additionally, intrathecal AAV-GlyRα3 administration to SD rats significantly decreased CFA-induced inflammatory pain and suppressed CFA-induced ERK phosphorylation, did not induce obvious histopathological injury but increased ATF-3 activation in dorsal root ganglion (DRGs).

Conclusions

Antagonists of the prostaglandin EP2 receptor, PKC, and glycine receptor can inhibit PGE2-induced ERK phosphorylation. Intrathecal AAV-GlyRα3 administration to SD rats significantly decreased CFA-induced inflammatory pain and suppressed CFA-induced ERK phosphorylation, did not significantly induce gross histopathological injury but elicited ATF-3 activation. We suggest that PGE2-induced ERK phosphorylation can be modulated by GlyRα3, and AAV-GlyRα3 significantly downregulated CFA-induced cytokine activation.
Sorptive removal of short-chain perfluoroalkyl substances (PFAS) during drinking water treatment using activated carbon and anion exchanger
Authors: Riegel Marcel , Haist-Gulde Brigitte , Sacher Frank
Published: February 2023

Laboratory tests and column tests were carried out in a waterwoks to investigate the removal of short- and long-chain PFAS using activated carbon filtration and ion exchange treatment. For all adsorbents, the sorption affinity of short-chain per- and polyfluoroalkyl carboxylic acids (PFCA) was significantly lower than that of long-chain PFAS or short-chain per- and polyfluoroalkyl sulfonic acids (PFSA). In the PFAS-polluted groundwater matrix, the short-chain PFCA PFBA and PFPeA could only be sufficiently removed with activated carbon over short run times of 6000 and 11,000 bed volumes (BV), respectively. Longer PFCA with a chain length of C6 or more were removed over longer run times.

The removal of short-chain PFCA using ion exchange media could also only be achieved over relatively short run times of 5000 BV for PFBA, 10,000BV for PFPeA and 18,000 BV for PFHxA. These are sometimes significantly longer than those of activated carbon. Due to the higher material costs for ion exchange media, there are nevertheless no lower operating costs when the ion exchangers are used in single-use mode. However, ion exchangers can be regenerated and then reused which can result in economic advantages compared to activated carbon filtration. However, for the extensive regeneration, especially for the elution of the long-chain PFAS, the additional use of ethanol is needed in the process. In contrast, the short-chain PFBA and PFPeA can be extracted without organic solvent from a weakly basic ion exchanger.
Is telemedicine a holy grail in healthcare policy: clinicians’ and patients’ perspectives from an Apex Institution in Western India
Authors: Gupta Nainsi , Gupta Manoj Kumar , Joshi Nitin Kumar , Mantri Neha , Sridevi G. , Patel Mamta , Goel Akhil Dhanesh , Singh Kuldeep , Garg M. K. , Bhardwaj Pankaj
Published: February 2023

Background

This study aimed to explore the perception of doctors regarding telemedicine consultations and the level of patient satisfaction with the services received through teleconsultations.

Methods

This cross-sectional study was conducted on clinicians who provided teleconsultations and patients who received teleconsultations in an Apex healthcare institution in Western India. Semi-structured interview schedules were used to record the quantitative and qualitative information. Clinicians’ perceptions and patients’ satisfaction were assessed using two different 5-point Likert scales. Data were analyzed using SPSS v.23 using non-parametric tests (Kruskal Wallis and Mann-Whitney U).

Results

A total of 52 clinicians who delivered teleconsultations and 134 patients who received teleconsultations from those doctors were interviewed in this study. For 69% of doctors, telemedicine was feasible to implement, and for the rest, it was challenging. Doctors believe telemedicine is convenient for patients (77%) and prevents the transmission of infection (94.2%). Difficulty in clinical evaluation (73%), communication (55.7%), network connectivity (34%), diagnosis and investigations (32%), and patients’ e-illiteracy (32%) were the most common challenges faced by clinicians. Patients’ experiences were positive in terms of ease of registration (82.1%), audio quality (100%), freedom to discuss medicine (94.8%), and comprehension of the diagnoses (88.1%). Patients expressed satisfaction with the length of the teleconsultation (81.4%), the advice and care they received (78.4%), and the manner and communication of the clinicians (78.4%).

Conclusions

Though there were some challenges in the implementation of telemedicine, the clinicians perceived it quite helpful. The majority of the patients were satisfied with teleconsultation services. Difficulty in registration, lack of communication, and a deep-rooted mindset of physical consultations were the primary concerns from the patient side.
Continuous relative phases of walking with an articulated passive ankle–foot prosthesis in individuals with a unilateral transfemoral and transtibial amputation: an explorative case–control study
Authors: Lathouwers Elke , Baeyens Jean-Pierre , Tassignon Bruno , Gomez Felipe , Cherelle Pierre , Meeusen Romain , Vanderborght Bram , De Pauw Kevin
Published: February 2023

Background

A mechanical ankle–foot prosthesis (Talaris Demonstrator) was developed to improve prosthetic gait in people with a lower-limb amputation. This study aims to evaluate the Talaris Demonstrator (TD) during level walking by mapping coordination patterns based on the sagittal continuous relative phase (CRP).

Methods

Individuals with a unilateral transtibial amputation, transfemoral amputation and able-bodied individuals completed 6 minutes of treadmill walking in consecutive blocks of 2 minutes at self-selected (SS) speed, 75% SS speed and 125% SS speed. Lower extremity kinematics were captured and hip–knee and knee–ankle CRPs were calculated. Statistical non-parametric mapping was applied and statistical significance was set at 0.05.

Results

The hip–knee CRP at 75% SS walking speed with the TD was larger in the amputated limb of participants with a transfemoral amputation compared to able-bodied individuals at the beginning and end of the gait cycle (p = 0.009). In people with a transtibial amputation, the knee–ankle CRP at SS and 125% SS walking speeds with the TD were smaller in the amputated limb at the beginning of the gait cycle compared to able-bodied individuals (p = 0.014 and p = 0.014, respectively). Additionally, no significant differences were found between both prostheses. However, visual interpretation indicates a potential advantage of the TD over the individual's current prosthesis.

Conclusion

This study provides lower-limb coordination patterns in people with a lower-limb amputation and reveals a possible beneficial effect of the TD over the individuals’ current prosthesis. Future research should include a well-sampled investigation of the adaptation process combined with the prolonged effects of the TD.
Efficacy and safety of lenalidomide in HIV-associated cryptococcal meningitis patients with persistent intracranial inflammation: an open-label, single-arm, prospective interventional study
Authors: Wan Zhikai , Tao Ran , Hui Jiangjin , Liu Xiang , Peng Xiaorong , Guo Yongzheng , Zhu Xueling , Huang Ying , Zhu Biao
Published: February 2023

Background

Patients with human immunodeficiency virus-associated cryptococcal meningitis (HIV-CM) have persistent intracranial inflammation despite negative cerebrospinal fluid (CSF) fungal cultures after optimal treatment for CM, which could be devastating for the central nervous system. However, a definitive treatment strategy for persistent intracranial inflammation despite optimal antifungal therapies is undefined.

Methods

We identified 14 HIV-CM patients with persistent intracranial inflammation and conducted a 24-week, prospective, interventional study. All participants received lenalidomide (25 mg, p.o.) on days 1 to 21 of a 28-day cycle. Follow-up lasted for 24 weeks with visits at baseline and weeks 4, 8, 12, and 24. The primary endpoint was the change in clinical manifestations, routine CSF parameters, and MRI findings after lenalidomide treatment. An exploratory analysis was made on changes in cytokine levels in CSF. Safety and efficacy analyses were undertaken in patients who received at least one dose of lenalidomide.

Results

Of 14 participants, 11 patients completed the 24 weeks of follow-up. Rapid clinical remission following lenalidomide therapy was observed. Clinical manifestations (fever, headache, altered mentation) were reversed fully by week-4 and remained stable during follow-up. A significant reduction in white blood cell (WBC) count in CSF was noted occurred at week-4 (P = 0.009). The median protein concentration in CSF decreased from 1.4 (0.7–3.2) g/L at baseline to 0.9 (0.6–1.4) at week-4 (P = 0.004). The median albumin concentration in CSF decreased from 79.2 (48.4–149.8) mg/L at baseline to 55.3 (38.3–89.0) mg/L at week-4 (P = 0.011). The WBC count, protein level, and albumin level in CSF remained stable and approached a normal range through week-24. There was no significant change in immunoglobulin-G, intracranial pressure (ICP), or chloride-ion concentration at each visit. Brain MRI demonstrated multiple lesions to be absorbed post-therapy. Levels of tumor necrosis factor-α granulocyte colony stimulating factor, interleukin (IL)-6, and IL-17A decreased significantly during 24-week follow-up. Two (14.3%) patients had mild skin rash, which resolved spontaneously. Lenalidomide-related serious adverse events were not observed.

Conclusion

Lenalidomide could improve persistent intracranial inflammation in HIV-CM patients significantly and was well tolerated without serious adverse events observed. And the additional randomized controlled study is required to further validate the finding.
Neural networks as a tool for domain translation of geophysical data
Authors: Yao Jiashun , Guasch Lluis , Warner Michael
Published: February 2023

Many geophysical tasks are hindered in practice by the high costs of generating and processing data. We have developed a potential solution, mitigating the cost of certain data acquisition and generation processes by using data-domain-translation deep neural networks. Generative adversarial networks have demonstrated success in data translation in a wide variety of applications. By providing training data from domain A and domain B, networks can be trained to estimate the distributions of both domains, and hence establish a mapping from one to the other. We apply such data-translation neural networks to 3D geophysical field data examples and determine that they can be used as cost-reduction tools, providing an efficient mapping between different data types of interest in expensive data-processing workflows. Our approach is especially relevant for the translation between acoustic and elastic data sets during full-waveform inversion, which mitigates the elastic effect in the acoustic inversion.
A projection-onto-convex-sets network for 3D seismic data interpolation
Authors: Chen Yao , Yu Siwei , Ma Jianwei
Published: February 2023

Seismic data interpolation is an essential procedure in seismic data processing. However, conventional interpolation methods may generate inaccurate results due to the simplicity of assumptions, such as linear events or sparsity. In contrast, deep learning trains a deep neural network with a large data set without relying on predefined assumptions. However, the lack of physical priors in the traditional pure data-driven deep learning frameworks may cause low generalization for different sampling patterns. Inspired by the framework of projection onto convex sets (POCS), a new neural network is proposed for seismic interpolation, called POCS-Net. The forward Fourier transform, the inverse Fourier transform, and the threshold parameter in POCS are replaced by neural networks that are independent in different iterations. The threshold is trainable in POCS-Net rather than manually set. A nonnegative constraint is imposed on the threshold to make it consistent with traditional POCS. POCS-Net is essentially an end-to-end neural network with priors of a sampling pattern and a predefined iterative framework. Numerical results on 3D synthetic and field seismic data sets demonstrate the superiority of the reconstruction accuracy of the proposed method compared with the traditional and natural image-learned POCS methods.
The pharmacological management of acute behavioural disturbance in pregnancy
Authors: Powell Jennifer , Taylor David , Manoharan Manonmani
Published: February 2023

Acute behavioural disturbance is relatively common during the perinatal period. The management of agitation in pregnant women is similar to that in the general population, although with some additional considerations, such as modifications to restraint techniques, careful medication selection, monitoring of maternal and fetal well-being and the importance of a debrief. There are benefits of agreeing a pre-determined care plan for women who are at risk.
Assessing the Contribution of Scanned Outside Documents to the Completeness of Real-World Data Abstraction
Authors: Zhao Yayi , Howard Rachel , Amorrortu Rossybelle P. , Stewart Sandra C. , Wang Xiaoliang , Calip Gregory S. , Rollison Dana E.
Published: February 2023

PURPOSE

Electronic health record (EHR) data are widely used in precision medicine, quality improvement, disease surveillance, and population health management. However, a significant amount of EHR data are stored in unstructured formats including scanned documents external to the treatment facility presenting an informatics challenge for secondary use. Studies are needed to characterize the clinical information uniquely available in scanned outside documents (SODs) to understand to what extent the availability of such information affects the use of these real-world data for cancer research.

MATERIALS AND METHODS

Two independent EHR data abstractions capturing 30 variables commonly used in oncology research were conducted for 125 patients treated for advanced non–small-cell lung cancer at a comprehensive cancer center, with and without consideration of SODs. Completeness and concordance were compared between the two abstractions, overall, and by patient groups and variable types.

RESULTS

The overall completeness of the data with SODs was 77.6% as compared with 54.3% for the abstraction without SODs. The differences in completeness were driven by data related to biomarker tests, which were more likely to be uniquely available in SODs. Such data were prone to missingness among patients who were diagnosed externally.

CONCLUSION

There were no major differences in completeness between the two abstractions by demographics, diagnosis, disease progression, performance status, or oral therapy use. However, biomarker data were more likely to be uniquely contained in the SODs. Our findings may help cancer centers prioritize the types of SOD data being abstracted for research or other secondary purposes.
Validity and Accuracy of Impulse-Response Models for Modeling and Predicting Training Effects on Performance of Swimmers
Authors: BUSSO THIERRY , CHALENCON SÉBASTIEN
Published: February 2023

Purpose

The aim of this study was to compare the suitability of models for practical applications in training planning.

Methods

We tested six impulse-response models, including Banister’s model (Model Ba), a variable dose–response model (Model Bu), and indirect-response models differing in the way they account or not for the effect of previous training on the ability to respond effectively to a given session. Data from 11 swimmers were collected during 61 wk across two competitive seasons. Daily training load was calculated from the number of pool-kilometers and dry land workout equivalents, weighted according to intensity. Performance was determined from 50-m trials done during training sessions twice a week. Models were ranked on the base of Aikaike’s information criterion along with measures of goodness of fit.

Results

Models Ba and Bu gave the greatest Akaike weights, 0.339 ± 0.254 and 0.360 ± 0.296, respectively. Their estimates were used to determine the evolution of performance over time after a training session and the optimal characteristics of taper. The data of the first 20 wk were used to train these two models and predict performance for the after 8 wk (validation data set 1) and for the following season (validation data set 2). The mean absolute percentage error between real and predicted performance using Model Ba was 2.02% ± 0.65% and 2.69% ± 1.23% for validation data sets 1 and 2, respectively, and 2.17% ± 0.65% and 2.56% ± 0.79% with Model Bu.

Conclusions

The findings showed that although the two top-ranked models gave relevant approximations of the relationship between training and performance, their ability to predict future performance from past data was not satisfactory for individual training planning.
Xeropicta derbentina (Krynicki, 1836) (Gastropoda: Eupulmonata: Geomitridae) in Belarus – new data
Authors: Ostrovsky Artsiom M.
Published: February 2023

A new addition to the fauna of Belarus, the land snail species Xeropicta derbentina has been found in Gomel city. The material was collected in 2022. There are no earlier reports of this species from Belarus, and this locality is the most northerly known. The shells and reproductive anatomy of X. derbentina from Gomel are described and illustrated. It is likely that the species has been passively dispersed by railway transport.
COVID-19 anxiety and uncertainty of classes: Devastating effect on students’ academic behavior and performance
Authors: Kulal Abhinandan , Rahiman Habeeb Ur
Published: February 2023

Background: The second wave of coronavirus disease 2019 (COVID-19) upsurged the level of anxiety among students and in addition to this, frequent closure of class, switching of teaching and learning to virtual added more agony to academic life. This study aimed to assess the impact of COVID-19 anxiety and uncertainty in class on academic performance moderated through academic behavior.

Methods: A structured questionnaire was developed to collect primary data and was distributed to 480 students using a systematic sampling technique. A structured equation model was developed and tested with a few hypotheses to answer the research objectives. A conceptual model was developed with the help of literature in order to understand causal relationship between study variables and tested with the help of the structured equation model.

Results: The study results showed that COVID-19 anxiety and uncertainty in classes negatively impacted students' academic behaviour, which lead to students' poor performance. The study identified that COVID-19 anxiety and uncertainty of class do not have a direct impact on academic performance; it only has an indirect negative impact on academic performance.

Conclusions: It can be concluded that uncertainty of classes during lockdown increased anxiety among students and it negatively impacted the academic behaviour of the students which lead to poor academic performance. The study helps the policymakers of the education sector to uplift the spirit of students in this pandemic situation and motivate the students to keep hope in their future careers; therefore, this study helps to fill that gap by contributing a working model