bluuebunny/crossref_metadata_2025 huggingface dataset:
The Prediction Algorithm and Characteristics Analysis of Kuroshio Sea Surface Temperature Anomalies
Authors: Shi Dawei , Li Chao , Zhu Zhu , Lv Runqing , Chen Shengjie , Zhu Yunfeng
Published: April 2022

Based on 130 climate signal indexes provided by National Climate Center of China, this paper established a decision tree diagnostic prediction model for Spring Kuroshio Sea Surface Temperature (SST) from 1961 to 2015 (65 years) by using Chi-Squared Automatic Interaction Detector (CHAID) algorithm in data mining and obtained five rule sets to determine whether Spring Kuroshio SST is high or not. Considering the data of the 44 years from 1961 to 2004 as the training set of the model and the other years as the test set, the training accuracy of the model can reach to 95.45% and the test accuracy can reach to 81.82%. Three types of Spring Kuroshio SST are different in intensity and distribution. The results show that the prediction model of Spring Kuroshio SST based on CHAID algorithm has a high prediction accuracy, with the reasonable and effective model and the well-thought-out decision rules. Moreover, based on the results of decision classification, the SST anomalies correspond to different distribution characteristics of summer daily precipitation anomalies in eastern China, which can provide a new idea and method for climate prediction of regional summer precipitation.
A New Idea to Evaluate Networking Problem and MCGDM Problem in Parametric Interval Valued Pythagorean Arena
Authors: Chakraborty Avishek , Mondal Sankar Prasad , Alam Shariful , Pamucar Dragan , Marinkovic Dragan
Published: April 2022

In this article, the concept of parametric interval valued Pythagorean number (PIVPN) has been introduced, which is an extended version of Pythagorean number (PN). Here, a new score and accuracy function have been innovated in the PIVPN environment along with the De‐Pythagorean value concept. The new tool and techniques have been fruitfully applied to two realistic problems, namely the networking critical path model (CPM) problem and the multicriteria group decision making problem (MCGDM) problem. In order to solve the MCGDM problem, we have prepared Parametric Interval valued Pythagorean Weighted Arithmetic Mean Operator (PIVPWAMO) and Parametric Interval valued Pythagorean Weighted Geometric Mean Operator (PIVPWGMO) operator in PIVPN environment. Finally, sensitivity analysis and industrious comprehensive numerical simulations have been performed to identify the reliability, efficiency, and usefulness of this novel work. In this article, we have shown that PIVPNs are a more well‐organized representation to grip a real‐life problem, and they can handle inconsistent conditions in a better compatible way in comparison to the other existing methods.
Research on Collaborative Innovation of Animation Specialty in Colleges under Digital Technology
Authors: Wei Haiyan
Published: April 2022

Digital technology plays an important role in promoting the development of the animation industry. With the rapid development of digital technology in China, the wide application of digital technology in the animation field has become a new method of animation production, which also is an important way for the development of animation major in colleges. This paper studies the collaborative innovation of animation majors in colleges under digital technology, combined with the driving effect of digital technology on animation major, and a collaborative innovation system of animation major based on digital technology is constructed. Based on this, a collaborative innovation platform for animation projects is designed, which is dominated by universities and supplemented by governmental enterprises. The basic functions of animation knowledge integration, animation knowledge maintenance, animation knowledge retrieval, and animation knowledge sharing are implemented. The platform not only innovates the teaching mode of animation major in colleges but also promotes the development of the animation industry, which has practical applicated value.
Effects of a Combined Processes of Low-Pressure Steam Enrichment and Low-Pressure Superheated Steam Drying on the γ-Aminobutyric Acid Content of Japonica Rice
Authors: Li Yan , Che Gang , Wan Lin , Qu Tianqi , Zhang Qilin , Zhao Fengzhou
Published: April 2022

In order to improve the content of GABA in japonica rice, so as to improve the nutritional composition and enhance the added value of rice, this study explored a combined process of low-pressure steam enrichment of γ-aminobutyric acid (GABA) content in japonica rice and low-pressure superheated steam (LPSS) drying of japonica rice. The low-pressure energy and the energy stored in rice grains were used to promote water absorption and activation of rice germs in a steam environment. Under the action of glutamate decarboxylase, the germ glutamate underwent an enzymatic reaction to generate GABA, which was transferred to and stored in the rice endosperm due to the concentration gradient and water gradient. After germination, LPSS was successively applied to dry the rice grains. The response surface method was used to optimize the parameters of low-pressure wet steam enrichment and LPSS drying of the rice grains. The experimental results showed that when the pressure was 0.026 MPa, the temperature was 60.66°C, the time was 5.01 h, and the flow rate was 0.31 L/h; the GABA content produced by low-pressure wet steam germination of japonica rice peaked at 94.1751 mg/100 g. When the germinated and enriched japonica rice was put through LPSS drying with a pressure of 0.021 MPa, a temperature of 66.55°C, a time of 1.57 h, and a flow rate of 0.28 L/h, the GABA content peaked at 104.161 mg/100 g. The results show that the combined process of low-pressure steam enrichment and drying continuously produced GABA in the soaking enrichment and drying stages, and the content of GABA in the drying stage accounted for 10% of the total content, which effectively increased the content of GABA in japonica rice and shortened the enrichment time. This study provides a technical reference for industrialized production of GABA-rich brown rice, embryonic rice, and polished rice.
A Dynamic Model of Evolutionary Knowledge and Capabilities Based on Human-Machine Interaction in Smart Manufactures
Authors: Chen Shuxian , Ren Zongqiang , Yu Xikai , Huang Ao
Published: April 2022

The increasing use of smart machines and devices is not only changing production principles but also reshaping the value of cocreation logic. The interaction between human and smart machine is the enabler of generating augmented intelligence. A system dynamics model is abstracted from smart manufacturing practices to represent the evolutionary processes of inertia, capability, and reliability induced by human-machine interaction. Human-machine interaction is conceptualized into two dimensions: technical and cognitive interaction. Simulation experiments illustrate how the improvement of human-machine interaction can leverage the dynamic capability and reduce the inertia in enterprises through multiple nonlinear feedbacks. There are two pathways to improve reliability and performance in enterprises by human-machine interaction: (1) to promote initiative innovation (change) from endogenous enabler by improving dynamic capability and (2) to promote transformation of knowledge and variation triggered by exogenous environmental changes to improve the dynamic capability for the flexibility and reliability.
Effects of the Higenamine, a Potent Compound from Aconitum, on UVB-Induced Photoaging in Hairless Mice
Authors: Lim Hye-Sun , Jang Yumi , Park Gunhyuk
Published: April 2022

Aim. Higenamine [1-[(4-hydroxyphenyl) methyl]-1, 2, 3, 4-tetrahydroisoquinoline-6, 7-diol], a potent cardiotonic compound from Aconitum, contributes to vascular relaxation and bronchodilation. However, the effects and mechanisms of action of higenamine on skin aging remain poorly understood. In this study, the effects of higenamine on UVB-induced photoaging were examined in the hairless mouse model. Methods. The dorsal skin of hairless mice (CrlOri : SKH1) was exposed to chronic UVB irradiation (100–300 mJ/cm2 for 6 weeks), with subsequent administration of higenamine (1–20 mg/kg, p.o.) for 2 weeks. TGF-β, Smad3 DNA-binding phosphorylation, and COL1A1 levels were analyzed by immunohistochemistry, and histological analysis of the skin was performed via H&E and MT staining. Results. Higenamine increased TGF-β, Smad3 DNA-binding phosphorylation, and COL1A1 expression in primary human fibroblast cells and mouse skin. Higenamine suppressed UVB-induced photoaging via skin recovery, improved epidermal thickness, and prevented Smad3, DNA-binding phosphorylation, and COL1A1 depletion via TGF-β signaling. Conclusion. Higenamine enhances collagen production in the skin through TGF-β/Smad3 signaling and potentially suppresses UVB-induced skin aging.
Analysis of the Bearing Capacity of a Steel Structural Member after Reinforcement
Authors: Chen Chen , Tang Yake , Zhang Liang , Niu Kai , Meng Xiangrui , Yang Meng , Liu Juncai
Published: April 2022

To improve the bearing capacity of existing angle steel structures, a new and cost‐effective reinforcement method for increasing the load‐bearing capacity is proposed. This method uses steel pipes as auxiliary materials and clamps the reinforced angle steel and the auxiliary materials through fixtures to ensure that they are deformed together. The influence of the fixture spacing, the size of the reinforced angle steel member, the slenderness ratio of the members, the size of the auxiliary steel pipe, and other parameters on the reinforcement effect is studied. The results show that the smaller the fixture spacing is, the more obvious the improvement of the bearing capacity is, and the reasonable fixture spacing is related to the angle steel leg width. The larger the slenderness ratio of the member is, the more obvious the reinforcement effect of the scheme is. The steel pipe size has a significant impact on the reinforcement effect of the scheme.
Optimization of Network Furniture Management System Based on Big Data
Authors: Zhang Jiayi , Shi Lin
Published: April 2022

In order to make the traditional household equipment can be remotely controlled, wireless networking technology is introduced into the traditional furniture equipment to achieve the effect of access and remote control. In view of the problem that the traditional cloud storage system lacks flexibility, opacity, weak robustness and cannot effectively store, manage, and maintain big data in data storage, a big data oriented cloud storage system is designed and implemented to intelligently process the business requests of the furniture system through the logic control module. The user access module is used to provide users with various functions realized at the bottom, the storage module is used to provide transparent data access function for the furniture system, and the file read/write module is used to isolate the upper logic processing from the lower storage, so as to make the designed system more robust. In the process of software design, the program code of data cloud storage is given to realize big data cloud storage. The experimental results show that the new generation of network furniture cloud storage systems has high feasibility and practicability.
Analysis of Volatile Components in Tremella fuciformis by Electronic Nose Combined with GC-MS
Authors: Fu Lijun , Tian Jing , Liu Li , Ma Yongzheng , Zhang Xiumin , Ma Changyang , Kang Wenyi , Sun Yong
Published: April 2022

In order to quickly evaluate the quality of Tremella fuciformis, the volatile components of T. fuciformis from 4 provinces in China, including Hebei, Henan, Fujian, and Sichuan, were analyzed by electronic nose combined with gas chromatography-mass spectrometry (GC-MS), and the key aroma compounds were determined by relative odor activity value (ROAV). The results showed that the electronic nose combined with the principal component analysis method could distinguish the samples from four regions with good discrimination. At least 117 volatile components were detected in T. fuciformis by GC-MS and a total of 58, 59, 62, and 55 volatile components were identified from Hebei, Henan, Fujian, and Sichuan, respectively, of which there were 18 common components. The volatile components in T. fuciformis were mainly hydrocarbons, followed by aldehydes, acids, and esters, while acetic acid and hexanal were relatively rich in T. fuciformis. Based on the ROAV, 8 key components affecting the aroma of T. fuciformis strongly were found. Among them, hexanal, nonanal, and pentanal were the common components of T. fuciformis, while butyrolactone, 1-octen-3-ol, and 2-carene were the unique key aroma components of T. fuciformis in Hebei Province. Besides, octanal and butyrolactone were the special key components absent in the Sichuan and Henan samples, respectively.
Nanoconfined Bulk-Gas Transport Behavior over a Wide Range of Knudsen Number
Authors: Zhang Yi
Published: April 2022

Shale matrix, located at Guizhou Province, is rich in nanopores, and gas slippage takes place during shale gas development, resulting in inapplicability of the classical Navier-Stokes equation. Investigation of gas transmission mechanism in nanoscale is helpful to reach a clear understanding of shale gas production performance. On the basis of the Knudsen number, the gas flow mechanism is divided into continuous flow, slippage flow, transition flow, and Knudsen diffusion. Notably, the accurate characterization of transition flow is still challenging up to date. Although there are many established models, they either fail to cover all the flow mechanisms or contain many fitting parameters, the determination of which requires a large number of experimental and molecular simulation data, limiting application of the existing models. Therefore, establishment of bulk-gas transport model over a wide range of Knudsen number without fitting parameters is urgent. First of all, existed theoretical models are compared, and the advantages and disadvantages of previous contributions are analyzed. Weight factors of Knudsen diffusion and slippage flow are obtained, respectively, according to Knudsen’s model and Wu’s model. Then, a model, free of empirical coefficients, is proposed. After that, effects of pore size, reservoir pressure, and temperature on transmission capacity are investigated. As the proposed model does not contain fitting parameters and remains high accuracy over a wide range of Knudsen number, it shares broad application potential, like shale gas production prediction, reserve estimation in Guizhou Province.
First Patient Diagnosed as Feingold Syndrome Type 2 with Alport Syndrome and Review of the Current Literature
Authors: Demir Şenol , Söylemez Mehmet A. , Arman Ahmet , Ata Pınar
Published: April 2022

Introduction: Feingold syndrome type 2 (FGLDS2) is an ultra-rare genetic disorder characterized by short stature, microcephaly, digital abnormalities, and intellectual disability. Until now, 22 patients have been reported in the literature. FGLDS2 is caused by a germline heterozygous deletion of 13q resulting in haploinsufficiency of the MIR17HG gene. Case report: In the present study, we evaluated clinical, radiological, and genetic analyses of a 10-year-old Turkish-origin girl with short stature, brachydactyly, intellectual disability, hematuria, and proteinuria. Conclusion/Discussion: In the array-CGH analysis, a 15.7-Mb deletion, arr[hg19] 13q22q31.3(78,241,132_93,967,288)×1, was detected, and this alteration was evaluated to be pathogenic. The deletion of this region covering the MIR17HG gene is a potential cause of FGLDS2. Also, at her clinical exome sequencing study, a heterozygous c.2023G>A p.(Gly675Ser) variation was detected in the COL4A5 gene (NM_000495.4) that was likely pathogenic in up-to-date databases. As a result, we report on a patient who has FGLDS2 and Alport syndrome. This is the first report of a Turkish-origin FGLDS2 patient. Reporting new cases expands the range of phenotypes, plays a crucial role in understanding the FGLDS2 pathogenesis, and is important in terms of screening at-risk family members for giving appropriate genetic counseling and preimplantation genetic diagnosis opportunities.
Intralesional Treatments in Hidradenitis Suppurativa: A Systematic Review
Authors: Cuenca-Barrales Carlos , Montero-Vílchez Trinidad , Sánchez-Díaz Manuel , Martínez-López Antonio , Rodríguez-Pozo Juan Ángel , Díaz-Calvillo Pablo , Arias-Santiago Salvador , Molina-Leyva Alejandro
Published: April 2022

Hidradenitis suppurativa (HS) is an inflammatory chronic disease with difficult management. In some scenarios, intralesional (IL) treatments could be useful. However, the scientific evidence available is limited and heterogeneous. We aimed to synthesize the available scientific evidence on IL treatments in HS. We conducted a systematic review in July 2021. The clinical databases reviewed included MEDLINE and Embase. All types of epidemiological studies and case series with at least 10 patients were included; reviews, guidelines, protocols, conference abstracts, case series with less than 10 patients, and case reports were excluded. Fifteen articles representing 599 patients and 1,032 lesions were included for review. Corticosteroid injections were the most reported treatment. They showed effectiveness for the treatment of acute inflammatory lesions and fistulas in terms of reduction of lesion counts, symptoms, and signs of inflammation and were safe in general terms. Light-based therapies were the other main treatment group, including photodynamic therapy and 1,064-nm diode laser. They were also effective, but more local and systemic adverse events were reported. Other treatments included botulinum toxin type B and punch-trocar-assisted cryoinsufflation (cryopunch). They were effective and safe, although were reported anecdotally. The main limitation of the systematic review was the general quality of the articles included. In conclusion, IL treatments such as corticosteroid injections and light-based therapies seem to be effective and safe for both acute inflammatory lesions and fistulas, although more prospective studies, with higher sample sizes and with standardized outcomes are needed to provide more scientific evidence on the subject.
Cytogenomic Analysis of Long-Term Epilepsy-Associated Tumors Using an Array-Based CGH Strategy
Authors: Jesus-Ribeiro Joana , Ribeiro Ilda Patrícia , Pires Luís Miguel , Paiva Patrícia , Simões Sandra , Pereira Cristina , Robalo Conceição , Pereira Ricardo , Sales Francisco , Rebelo Olinda , Santana Isabel , Freire António , Barbosa Melo Joana
Published: April 2022

A palette of copy number changes in long-term epilepsy-associated tumors (LEATs) have been reported, but the data are heterogeneous. To better understand the molecular basis underlying the development of LEATs, we performed array-comparative genomic hybridization analysis to investigate chromosomal imbalances across the entire genome in 8 cases of LEATs. A high number of aberrations were found in 4 patients, among which deletions predominated. Both whole-chromosome and regional abnormalities were observed, including monosomy 19, deletion of 1p, deletions of 4p, 12p, and 22q, and gain of 20p. The common altered regions are located mainly on chromosomes 19 and 4p, identifying genes potentially involved in biological processes and cellular mechanisms related to tumorigenesis. Our study highlights new genomic alterations and reinforces others previously reported, offering new molecular insights that may help in diagnosis and therapeutic decision-making.
Anxiety, Depression and Quality of Life in Pulmonary Hypertension: A Comparison of Incident and Prevalent Cases
Authors: Pfeuffer-Jovic Elena , Joa Franziska , Halank Michael , Krannich Jens-Holger , Held Matthias
Published: April 2022

Introduction: Anxiety and depression are common in pulmonary hypertension (PH) and health-related quality of life (HRQoL) is reduced. Sufficient analyses in incident and prevalent patients are lacking, so we provide a comparative analysis of these groups with focus on anxiety, depression and HRQoL. Methods: Depression, anxiety and HRQoL were retrospectively analyzed by Hospital Anxiety and Depression Scale (HADS) and Short Form 36 questionnaire in 91 prevalent and 21 incident PH outpatients from a German tertiary care center specialized in PH. The acquired data as well as hemodynamic and functional parameters of prevalent and incident cases were compared. Results: HRQoL was reduced in both cohorts of patients. Incident patients had significantly worse HRQoL in physical dominated scales than prevalent patients (physical component summary score: p = 0.02; physical role performance: p < 0.01). Depression and anxiety were more pronounced in prevalent patients (elevated depression scales: 28.6% of incident group, 35.2% of prevalent group, elevated anxiety scores: 28.6% of incident group, 39.6% of prevalent group). The groups did not differ in hemodynamic data, but incident patients had significantly lower cardiac biomarkers such as NT-proBNP (p = 0.016) and hs-troponin (p = 0.017). The time since diagnosis was a predictor of the subscale physical role performance (p < 0.001). Conclusion: Physical domains of HRQoL seem to be more limited in incident patients with PH. Anxiety and depression are frequent in both groups. A screening for anxiety and depression is important from the onset of the diagnosis, and patients should receive appropriate therapy to improve HRQoL, anxiety and depression.
Epiretinal Membrane in Patients with Diabetic Macular Edema
Authors: Rabina Gilad , Hilely Assaf , Barequet Dana , Cohen Shai , Lipin Naama , Mimouni Michael , Glick Adina , Barak Adiel , Loewenstein Anat , Schwartz Shulamit
Published: April 2022

Purpose: The aim of the study was to compare anatomical and functional outcomes of pars plana vitrectomy (PPV) with epiretinal membrane (ERM) peeling in diabetes retinopathy patients with and without diabetic macular edema (DME). Methods: A retrospective interventional case series of consecutive patients who underwent PPV with ERM peeling. Patients were divided into two groups: those with and without preoperative DME. Visual acuity (VA) and optical coherence tomography parameters were evaluated before surgery and during 12 months of follow-up. Results: A total of 354 patients underwent PPV with ERM peeling, of which 51 met the inclusion criteria. Twenty-three were diagnosed with DME and were younger (66.3 ± 9.6 vs. 73.1 ± 8.2 years, p = 0.001), had longer diabetes mellitus (DM) duration (18.9 ± 7.1 vs. 14.3 ± 10.9 years, p = 0.04) and higher HbA1C% (7.6 ± 1.4 vs. 7.1 ± 1.3, p = 0.04). VA improved from 20/105 to 20/60 Snellen (p = 0.004) and central macular thickness decreased from 469.3 ± 64.9 μm to 331.1 ± 92.2 μm (p < 0.001) in the DME group and from 20/87 to 20/44 Snellen (p < 0.001) and from 463.1 ± 53.5 μm to 341.3 ± 49.5 μm (p = 0.01) in the non-DME group. Yearly intravitreal injection rate decreased from 5.9 ± 2.5 to 2.9 ± 3.0 (p < 0.001) injections in the DME group. Conclusions: DME patients with ERM experience significant improvement in VA, macular thickness, and yearly intravitreal injections after PPV with ERM peeling. DME patients are younger, with longer duration of DM and higher HbA1C% levels at presentation in comparison to diabetic ERM patients without DME.
Prácticas de gestión humana en zonas de contacto cultural escolarizadas: co-construcciones
Authors: Ortiz-Cifuentes Beatriz Elena , Chica-Lasso Marco Fidel
Published: April 2022

(analítico)El objetivo de esta investigación es comprender los saberes que construyen los sujetos respecto a las prácticas de gestión humana en las zonas de contacto cultural escolarizadas, como co-construcciones de la investigación social. Los colaboradores fueron seleccionados por su condición de representación en los grupos sociales: presidente del consejo de padres, personera escolar y maestras representantes del consejo directivo. La opción metodológica fue la etnografía colaborativa precedida por dos supuestos antropológicos: colaboración y diálogo de saberes. Las categorías abordadas enfatizan en gestión, humanismo, cultura escolar e identificaciones sociales. La parte conclusiva reconoce como prácticas de gestión humana derivadas del conflicto y la diferencia social, la sociología de la ontología política escolar y los agenciamientos de los estudiantes para socavar o reforzar las identificaciones sociales.
Palabras clave: Gestión; humanismo; educación; cultura escolar; identificaciones sociales; co-construcción.
Yield of Echocardiography in Ischemic Stroke and Patients With Transient Ischemic Attack With Established Indications for Long‐Term Direct Oral Anticoagulant Therapy: A Cross‐Sectional Diagnostic Cohort Study
Authors: Meinel Thomas R. , Brignoli Kristina , Kielkopf Moritz , Clenin Leander , Beyeler Morin , Scutelnic Adrian , Siepen Bernhard , Mueller Madlaine , Goeldlin Martina , Seiffge David , Kaesmacher Johannes , Mujanovic Adnan , Belachew Nebiyat F. , Fischer Urs , Arnold Marcel , Gräni Christoph , Seiler Christian , Buffle Eric , Jung Simon
Published: April 2022

Background

We aimed to determine the diagnostic yield of transthoracic (TTE) and transesophageal echocardiography (TEE) in patients with ischemic stroke and transient ischemic attack with established indications for direct oral anticoagulants before the index event.

Methods and Results

This was a retrospective cohort study of consecutive patients with preceding established indications for long‐term therapeutic direct oral anticoagulants presenting to a single comprehensive stroke center with ischemic stroke or transient ischemic attack. Choice of echocardiography modality was based on expert recommendations. The primary outcome was a composite of prespecified management‐relevant high‐risk findings adjudicated by an expert panel, based on TTE and TEE reports according to evidence‐based recommendations. Explorative analyses were performed to identify biomarkers associated with the primary outcome. Of 424 patients included (median [interquartile range] age, 78 [70–84] years; 175 [41%] women; National Institutes of Health Stroke Scale, 4 [1–12]; 67% atrial fibrillation), 292 (69%) underwent echocardiography, while 132 (31%) did not. Modality was TTE in 191 (45%) and TEE in 101 (24%). Median time from index event to echocardiography was 2 (1–3) days. TTE identified 26 of 191 (14%) patients with 35 management‐relevant pathologies. TEE identified 16 of 101(16%) patients with 20 management‐relevant pathologies. Most management‐relevant findings represented indicated coronary artery disease and valvular pathologies. In a further 3 of 191 (2%) patients with TTE and 4 of 101 (4%) patients with TEE, other relevant findings were identified. Variables associated with management‐relevant high‐risk pathologies included more severe stroke, diabetes, and laboratory biomarkers (NT‐proBNP [N‐terminal pro‐B‐type natriuretic peptide], C‐reactive protein,
d
‐dimer, and troponin levels).

Conclusions

In patients with established indications for long‐term direct oral anticoagulant therapy and stroke who received echocardiography, both TTE and TEE identified a relevant and similar proportion of management‐relevant high‐risk pathologies and predictive biomarkers could help to guide diagnostic workup in such patients.
Scaling Notebooks as Re-configurable Cloud Workflows
Authors: Wang Yuandou , Koulouzis Spiros , Bianchi Riccardo , Li Na , Shi Yifang , Timmermans Joris , Kissling W. Daniel , Zhao Zhiming
Published: April 2022

Literate computing environments, such as the Jupyter (i.e., Jupyter Notebooks, JupyterLab, and JupyterHub), have been widely used in scientific studies; they allow users to interactively develop scientific code, test algorithms, and describe the scientific narratives of the experiments in an integrated document. To scale up scientific analyses, many implemented Jupyter environment architectures encapsulate the whole Jupyter notebooks as reproducible units and autoscale them on dedicated remote infrastructures (e.g., highperformance computing and cloud computing environments). The existing solutions are still limited in many ways, e.g., 1) the workflow (or pipeline) is implicit in a notebook, and some steps can be generically used by different code and executed in parallel, but because of the tight cell structure, all steps in the Jupyter notebook have to be executed sequentially and lack of the flexibility of reusing the core code fragments, and 2) there are performance bottlenecks that need to improve the parallelism and scalability when handling extensive input data and complex computation.

In this work, we focus on how to manage the workflow in a notebook seamlessly. We 1) encapsulate the reusable cells as RESTful services and containerize them as portal components, 2) provide a composition tool for describing workflow logic of those reusable components, and 3) automate the execution on remote cloud infrastructure. Empirically, we validate the solution's usability via a use case from the Ecology and Earth Science domain, illustrating the processing of massive Light Detection and Ranging (LiDAR) data. The demonstration and analysis show that our method is feasible, but that it needs further improvement, especially on integrating distributed workflow scheduling, automatic deployment, and execution to develop as a mature approach.
Clarification of morphological characters and geographical distribution of Artemisia neosinensis (Asteraceae, Anthemideae), a strikingly misunderstood species from China
Authors: GUO XIN-QIANG , WANG LONG , YANG QIN-ER
Published: April 2022

Based on observations on both herbarium specimens (including type material) and living plants in the wild, we demonstrate that the Chinese species Artemisia neosinensis (Asteraceae, Anthemideae) has been strikingly misunderstood by previous authors and its geographical range has been wrongly largely extended. All the non-type specimens cited under this species by them belong to misidentifications, whereas the specimens of true A. neosinensis have been wrongly referred to other species. This species is characterized by having 1-pinnatisect, adaxially tomentose, abaxially arachnoid-tomentose leaves with ovate-acuminate or ovate lobules of segments, and campanulate capitula with abaxially arachnoid-tomentose phyllaries. It is distributed only in western Sichuan and northwestern Yunnan, not in Gansu, Qinghai and Xizang. The syntypes of A. strongylocephala var. sinensis f. virgata, a synonym of A. neosinensis, include two taxa, A. neosinensis and A. tangutica var. tomentosa. Lectotypification is thus proposed for A. strongylocephala var. sinensis f. virgata.
A new species of Bulbophyllum (Orchidaceae: Epidendroideae) from Kalimantan Barat, Indonesia
Authors: KURNIAWAN FIRMAN H. , YUDISTIRA YUDA R. , MUSTAQIM WENDY A.
Published: April 2022

Bulbophyllum sungaiutikense is a new orchid species from Kapuas Hulu, Kalimantan Barat, Indonesia, and a member of the B. sect. Beccariana, allied to B. nabawanense. It differs from the latter in having tetragonal lateral sepals with an elongate triangular apical part, long acuminate petals, different and longer labellum with flattened base and verrucose adaxial surface. Notes on ecology and phenology, discussion of morphologically similar species, amendments to the key to B. sect. Beccariana in Borneo, illustrations and photographs are included here.
Cirsium hupingshanicum (Asteraceae, Cardueae), a new species from Hunan, China
Authors: JIN ZI-CHAO , CHEN YOU-SHENG
Published: April 2022

Cirsium hupingshanicum Z. C. Jin & Y. S. Chen, a new species of the Asteraceae from Hunan, China, is described and illustrated. This new species is similar to C. japonicum Fisch. ex DC. and C. racemiforme Ling et C. Shih. It differs from C. japonicum in its white corolla, plant ca. 120–180 cm high and basal leaf blade elliptic. It can readily be distinguished from the latter by its white corolla, long pedicel, basal leaves shape and morphology of capitula.
Molecular phylogeny of the Sceloporus torquatus species-group (Squamata: Phrynosomatidae)
Authors: MARTÍNEZ-MÉNDEZ NORBERTO , LA CRUZ FAUSTO R. MÉNDEZ-DE
Published: April 2022

The genus Sceloporus is one of the largest genus of lizards in North and Central America, with 22 species groups. Among these, the torquatus group has a notably wide geographic distribution with populations occurring from southern United States to Guatemala. In spite of the taxonomical work done with the group, some problems remain unsolved. We therefore obtained the phylogeny of the torquatus group, based on 925 bp of the ribosomal 16S gene, 912 bp of the ribosomal 12S gene, and 893 bp of the ND4 gene, for a total of 54 specimens of 25 taxa. The genes were analyzed, both separately and combined, by means of maximum parsimony and Bayesian inference analyses. The subspecies of S. serrifer did not form a monophyletic group. The sequence data refuted the morphological evidence that suggested that S. s. plioporus and S. cyanogenys are closely related to S. s. serrifer and to S. s. prezygus. Regardless, these last two were recovered as sister taxa. Moreover, evidence was found that S. ornatus does not form a monophyletic group, and that S. ornatus ornatus and S. oberon are a single species, despite their marked differences in coloration and scutelation. In addition, the non-monophyly of S. mucronatus was confirmed and the phylogenetic relationships of its different species were determined. At the same time, the subspecies of S. dugesii were recovered as a monophyletic group, refuting the nonmonophyly of this taxon suggested in the phylogenetic hypothesis of the entire genus.
Changes in the Relationship between ENSO and the Winter Arctic Stratospheric Polar Vortex in Recent Decades
Authors: Zhang Ruhua , Zhou Wen , Tian Wenshou , Zhang Yue , Liu Zhenchen , Cheung Paxson K. Y.
Published: April 2022

The impact of El Niño–Southern Oscillation (ENSO) on the winter stratospheric polar vortex intensity (PVI) is re-examined, using JRA-55 datasets and the CESM2 model. Our results show that the negative correlation between ENSO and PVI has weakened in recent decades and is no longer statistically significant after the mid-1990s. This weakening ENSO–PVI relationship after the mid-1990s is associated with wave-1 fluxes entering the stratosphere; that is, the ENSO-induced increasing wave-1 fluxes are weaker after the mid-1990s than before the mid-1990s. Except for the Pacific–North America (PNA)-like wave train, the stratospheric wave flux changes are related to ENSO-induced geopotential height changes over East Asia. The ENSO-induced tropical zonal circulation anomalies are enhanced from the central Pacific to East Asia, leading to more substantial wave flux anomalies propagating westward from the central Pacific to East Asia and a more significant high center over Northeast Asia after the mid-1990s than before the mid-1990s. This ENSO-induced high center after the mid-1990s is out of phase with the climatological center of wave 1, leading to a relatively weaker increase in wave 1. Model results show that changes in the ENSO–PVI relationship and ENSO–Asia circulation are associated with changes in ENSO-related SST combined with global mean SST.

Significance Statement

In this study, changes in the ENSO–polar vortex relationship and the relevant mechanisms are analyzed from the perspective of the ENSO-induced East Asia circulation. The results can help us better understand and predict variations in the stratospheric polar vortex.
Bridgesite-(Ce), a new rare earth element sulfate, with a unique crystal structure, from Tynebottom Mine, Cumbria, United Kingdom
Authors: Rumsey Mike S. , Hawthorne Frank C. , Spratt John , Najorka Jens , Montgomery Wren
Published: April 2022

Bridgesite-(Ce), (IMA2019-034), was discovered at Tynebottom Mine, Cumbria, UK. It occurs as thin (1–2 μm) translucent blue crystals with a lath-like to acicular habit, aggregated into thin crusts and is associated mainly with brochantite, malachite, serpierite, devilline, gypsum, aragonite, jarosite, pyrite, lanthanite-(Ce) and undifferentiated iron oxyhydroxides, it is often intergrown with these other minerals. The lustre, hardness, cleavage and parting could not be determined, nor could density be measured due to crystal size. It has a pale blue streak and is brittle with a splintery fracture. Bridgesite-(Ce) is biaxial (–), shows no pleochroism and has refractive indices (white light): α = 1.526(2), β = 1.564(2), γ = 1.572(2) and 2V(calc) = 48.3°. The empirical formula calculated on the basis of 44 negative charges is Ca0.86REEΣ1.99Al0.07Cu5.95(SO4)3.99(SiO4)0.05(PO4)0.02(OH)11.52⋅8H2O. The idealised formula is CaCe2Cu6(SO4)4(OH)12⋅8H2O, requiring (wt.%): 3.91 CaO, 22.89 Ce2O3, 33.28 CuO, 22.33 SO3 and 17.59 H2O. Bridgesite-(Ce) is monoclinic, space group C2/m, a = 24.801(5), b = 6.3520(13), c = 11.245(2) Å, β = 114.51(3)°, V = 1611.9(6) Å and Z = 2. The five most intense X-ray diffraction peaks in the measured pattern are [d in Å (I, %) (hkl)]: 11.3 (100) (200), 6.391 (15) (201), 2.770 (8) (420), 3.194 (6) (402) and 4.858 (5) (310). The crystal structure was solved using single crystal data and refined to an R1 index of 5.86%. Bridgesite-(Ce) contains three distinct Cu sites containing Cu2+, two are coordinated octahedrally and one is square pyramidal. The octahedra form chains through edge sharing parallel to the b-axis which are linked by the square pyramid to form sheets oriented parallel to {100}. Sulfate tetrahedra decorate the sheets which are held together by interstitial REE3+, Ca2+ and hydrogen bonding. The structure is unique. Despite apparent similarity in chemical formula, bridgesite-(Ce) is not closely related to any other natural Cu-sulfate mineral. An FTIR absorption spectra is presented for reference purposes.
Whole-genome sequencing reveals complex genomic features underlying anti-CD19 CAR T-cell treatment failures in lymphoma
Authors: Jain Michael D. , Ziccheddu Bachisio , Coughlin Caroline A. , Faramand Rawan , Griswold Anthony J. , Reid Kayla M. , Menges Meghan , Zhang Yonghong , Cen Ling , Wang Xuefeng , Hussaini Mohammad , Landgren Ola , Davila Marco L. , Schatz Jonathan H. , Locke Frederick L. , Maura Francesco
Published: April 2022

CD19-directed chimeric antigen receptor (CAR-19) T cells are groundbreaking immunotherapies approved for use against large B-cell lymphomas. Although host inflammatory and tumor microenvironmental markers associate with efficacy and resistance, the tumor-intrinsic alterations underlying these phenomena remain undefined. CD19 mutations associate with resistance but are uncommon, and most patients with relapsed disease retain expression of the wild-type receptor, implicating other genomic mechanisms. We therefore leveraged the comprehensive resolution of whole-genome sequencing to assess 51 tumor samples from 49 patients with CAR-19–treated large B-cell lymphoma. We found that the pretreatment presence of complex structural variants, APOBEC mutational signatures, and genomic damage from reactive oxygen species predict CAR-19 resistance. In addition, the recurrent 3p21.31 chromosomal deletion containing the RHOA tumor suppressor was strongly enriched in patients for whom CAR T-cell therapy failed. Pretreatment reduced expression or monoallelic loss of CD19 did not affect responses, suggesting CAR-19 therapy success and resistance are related to multiple mechanisms. Our study showed that tumor-intrinsic genomic alterations are key among the complex interplay of factors that underlie CAR-19 efficacy and resistance for large B-cell lymphomas.
Effect of 3D-printed hearts used in left ventricular outflow tract obstruction: a multicenter study
Authors: Wang Xianzhi , Liang Jixiang , Mu Cunfu , Zhang Wenlin , Xue Chunzhu , He Yang , Zhang Gen , Li Dianyuan
Published: April 2022

Objective

The purpose of this research was to explore the application value of a three-dimensional (3D)-printed heart in surgery for left ventricular outflow tract (LVOT) obstruction.

Methods

From August 2019 to October 2021, 46 patients with LVOT obstruction underwent surgical treatment at our institution. According to the treatment method, 22 and 24 patients were allocated to the experimental and control groups, respectively. In the experimental group, each patient’s 3D-printed heart model was used for simulated preoperative surgery, and then the Morrow operation was performed. In the control group, only the Morrow operation was performed, without simulated preoperative surgery using a 3D-printed heart model. The intraoperative and postoperative data of patients in the two groups were recorded, and the clinical data of patients were compared between the two groups.

Results

The operation time, cardiopulmonary bypass time, intraoperative blood loss, hospitalization time, LVOT pressure difference (LVP), postoperative interventricular septal thickness (IST), aortic regurgitation (AR), systolic anterior motion (SAM), and postoperative left ventricular flow velocity (LVFV) were significantly lower in the experimental group than in the control group (P < 0.05). The inner diameter of the left ventricular outflow tract (IDLV) was larger in the experimental group than in the control group (P < 0.05). There was no significant difference in the postoperative ejection fraction, atrioventricular block rate or complication rate between the two groups (P > 0.05).

Conclusion

A 3D-printed heart model for simulated surgery in vitro is conducive to formulating a more reasonable surgical plan and reducing the trauma and duration of surgery, thereby promoting the recovery and maintenance of the heart.
Mixed-dust pneumoconiosis in a dental technician: a multidisciplinary diagnosis case report
Authors: Di Lorenzo Luigi , Inchingolo Francesco , Pipoli Antonella , Cassano Filippo , Maggiore Maria Elena , Inchingolo Angelo Michele , Ceci Sabino , Patano Assunta , Malcangi Giuseppina , Mancini Antonio , Longo Giosi , Attimonelli Rossella , Maiorano Eugenio , Laviano Rocco , Manghisi Nicola Mariano , Scarano Antonio , Lorusso Felice , Di Lorenzo Antonio , Inchingolo Alessio Danilo , Dipalma Gianna
Published: April 2022

Background

In dental laboratories, exposure to crystalline silica can occur during procedures that generate suspended mineral dusts, e.g. dispersion of mixing powders, removal of castings from molds grinding, polishing of castings and porcelain, and use of silica sand for blasting. There is also a large list of toxic agents (acrylic resins, polymeric materials, etc.) used to produce removable and fixed prostheses, but also impression materials and more. Using personal protective equipment and other aids reduces the exposure to these potentially harmful agents.

Case presentation

We report the case of a 42-year-old male dental technician who began to suffer from a dry cough and exertional dyspnea after approximately 15 years of work. The operations he conducted for his job resulted in the generation of crystalline silica, aluminum, chromium and titanium dust. The worker did not regularly wear personal protective equipment and some of the above operations were not carried out in closed circuit systems. The Chest X-ray showed diffused micronodules in the pulmonary interstitium of the upper-middle lobes, bilaterally, and a modest left basal pleural effusion. Simple spirometry showed small airway obstruction in its initial stage. High Resolution Computerized Tomography of the chest showed bilateral micronodulation of a miliariform type, with greater profusion to the upper lobes, also present in the visceral pleura, bilaterally. Histological examination showed aggregates of pigment-laden macrophages forming perivascular macules or arranged in a radial pattern around a core of sclerohyalinosis. Scanning Electron Microscopy and Energy Dispersive Spectrometry revealed several mineral particles, typically characterized by the presence of crystalline silica and metal aggregates. The environmental concentrations of total dust and its respirable fraction were all lower than the relative TLV-TWA—ACGIH, yet not negligible.

Conclusions

The above findings and a multidisciplinary assessment led to the diagnosis of mixed dust pneumoconiosis s/q with 2/2 profusion of occupational origin. This diagnosis in a dental technician was supported for the first time in literature by environmental exposure analysis.
Efficacy of anterior debridement and bone grafting with fusion using internal fixation combined with anti-tuberculosis chemotherapy in the treatment of subaxial cervical tuberculosis
Authors: Luan Haopeng , Liu Kai , Wang Yao , Kahaer Alafate , Sheng Weibin , Maimaiti Maierdan , Deng Qiang
Published: April 2022

Background

To evaluate the efficacy of anterior debridement and bone grafting with fusion using internal fixation (BFIF) combined with anti-tuberculosis chemotherapy in the treatment of subaxial cervical spine tuberculosis (SCS-TB).

Methods

Clinical and radiographic data of patients with SCS-TB treated by anterior debridement and BFIF at our hospital from January 2010 to December 2017 were analyzed retrospectively. The SCS sagittal parameters at the preoperative, postoperative, and final follow-up were documented and compared, including the Occiput-C2 angle, C2–C7 Cobb angle, local Cobb angle, spinal canal angle (SCA), C2–C7 sagittal vertical axis (C2–C7 SVA), the center of gravity of the head-C7 sagittal vertical axis (CGH-C7 SVA), T1 slope (T1S), neck tilt (NT), and thoracic inlet angle (TIA). The ASIA grade, NDI index, JOA score, and VAS score were utilized to assess the postoperative function recovery, and the complications were recorded.

Results

A total of 23 patients were included in the study with a mean age of 46.74 ± 15.43 years, including 8 males and 15 females. All patients with SCS-TB were treated with anterior debridement and BFIF, with a mean postoperative follow-up time of 37.17 ± 12.26 months. The poisoning symptoms of TB were relieved in all patients, and ESR (42.09 ± 9.53 vs 8.04 ± 5.41, P < 0.05) and CRP (30.37 ± 16.02 vs 7.4 ± 2.68, P < 0.05) were decreased at the 3 postoperative months in the comparison of the preoperative. The C0–C2 Cobb angle, C2–C7 Cobb angle, local Cobb angle, SCA, TIS, C2–C7 SVA, and CGH-C7 SVA were corrected remarkably after surgery (P < 0.05). Further, there was a significant improvement in the JOA, VAS, and NDI with the comparison of the preoperative (P < 0.05).

Conclusions

Anterior debridement and BFIF combined with anti-TB chemotherapy was a practical tool for the treatment of SCS-TB with the help of SCS sagittal parameters, which can remove the lesion completely, decompress the spinal cord compression, and correct the kyphotic deformity to restore the spine sagittal balance.