bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemical generation of checkpoint inhibitory T cell engagers (CiTEs) for the treatment of cancer
Authors: Szijj Peter A. , Gray Melissa A. , Ribi Mikaela K. , Bahou Calise , Nogueira João C. F. , Bertozzi Carolyn R. , Chudasama Vijay
Published: May 2023

Bispecific antibodies (bsAbs) provide enticing therapeutic opportunities in the area of immunotherapy, especially in the field of immuno-oncology. These constructs can bind two separate antigenic epitopes and thus provide access to unique mechanisms of action (MoAs). A key MoA is unlocked by bispecific T cell engagers (BiTEs), which cause T cells to be cross-linked with a targeted cancer cell, ultimately leading to death of the targeted cell. It has been shown that the combination of a BiTE with checkpoint inhibition, such as blockade of the PD-1/PD-L1 pathway, can lead to a synergistic effect and greater efficacy. Constructs built from a BiTE core (anti-CD3/anti-cancer antigen) with an immunomodulatory protein added, have been dubbed checkpoint-inhibitory T cell-engagers (CiTEs). Both bsAbs and CiTEs have traditionally been generated via protein engineering. However, recently, improved chemical methods for the construction of bsAbs have been reported. This includes a strategy developed by the Chudasama and Baker groups to synthesize homogenous fragment-based bsAbs from antibodies’ fragments antigen binding (Fabs), utilising click-enabled pyridazinediones (PDs) for functional disulfide re-bridging, followed by strain-promoted inverse electron-demand Diels-Alder cycloaddition (SPIEDAC) click chemistry to attach the two Fabs to each other. In this paper, we describe a first-in-class chemical method to generate biotin-functionalized three-protein conjugates, building significantly on the previously described PD-method. The three-protein constructs generated here include two such CiTE molecules, one containing an anti-PD-1 Fab, the other containing an immunomodulatory enzyme Salmonella typhimurium sialidase; FabCD3-FabHER2-FabPD-1-Biotin and FabHER2-FabCD3-Sia-Biotin. These constructs (along with suitable controls) were tested for their biological activity, and each of their protein components were shown to retain their function. Their efficacy was also compared to a simpler BiTE scaffold and was shown to be superior, with the sialidase-containing CiTE especially showing significantly enhanced potency in vitro. The chemical method described here has the potential to enable the rapid generation of a plethora of multi-protein constructs, which we envisage would be especially useful in hit-identification screening but could also potentially be scaled up for drug-development after further optimization.
Resolving coupled pH titrations using non-equilibrium free energy calculations
Authors: Wilson Carter J. , de Groot Bert L. , Gapsys Vytautas
Published: May 2023

In a protein, nearby titratable sites can be coupled: the (de)protonation of one may affect the other. The degree of this interaction depends on several factors and can influence the measured pKa. Here, we derive a formalism based on double free energy differences (ΔΔG) for quantifying the individual site pKa values of coupled residues. As ΔΔG values can be obtained by means of alchemical free energy calculations, the presented approach allows for a convenient estimation of coupled residue pKas in practice. We demonstrate that our approach and a previously proposed microscopic pKa formalism, can be combined with non-equilibrium (NEQ) alchemical free energy calculations to resolve pH-dependent protein pKa values. Toy models and both, regular and constant-pH molecular dynamics simulations, alongside experimental data, are used to validate this approach. Our results highlight the insights gleaned when coupling and microstate probabilities are analyzed and suggest extensions to more complex enzymatic contexts. Furthermore, we find that naïvely computed pKa values that ignore coupling, can be significantly improved when coupling is accounted for, in some cases reducing the error by half. In short, our results suggest that free energy methods can resolve the pKa values of both uncoupled and coupled residues.
Exploiting locality in FCIQMC for fast excitation generation
Authors: Weser Oskar , Alavi Ali , Li Manni Giovanni
Published: May 2023

In this paper we propose an improved excitation generation algorithm for the full configuration interaction quantum monte carlo (FCIQMC) method, which is particularly effective in systems described by localized orbitals. The method is an extension of the precomputed heat-bath (PCHB) strategy of Holmes et al., with more effective sampling of double excitations and a novel approach for non-uniform sampling of single excitations. We demonstrate the effectiveness of the algorithm for a chain of 30 hydrogen atoms with atom-localized orbitals, a stack of benzene molecules, an Fe-porphyrin model complex, whereby we show an overall efficiency gain by a factor of two to four, as measured by variance reduction per wall-clock time.
Effect of molecular concentration on excitonic nanostructure based refractive index sensing and near-field enhanced spectroscopy
Authors: Dutta Arpan , Toppari J. Jussi
Published: May 2023

Organic thin film based excitonic nanostructures are of a great interest in modern resonant nanophotonics as a promising alternative for plasmonic systems. Such nanostructures sustain propagating and localized surface exciton modes which can be exploited in refractive index sensing and near-field enhanced spectroscopy. To realize these surface excitonic modes and to enhance their optical performance, the concentration of the excitonic molecules present in the organic thin film has to be quite high so that a large oscillator strength can be achieved. Unfortunately, this often results in a broadening of the material response which might prevent achieving the very goal. Therefore, systematic and in-depth studies are needed on the molecular concentration dependence of the surface excitonic modes to acquire optimal performance from them. Here, we study the effect of molecular concentration in terms of oscillator strength and Lorentzian broadening on various surface excitonic modes when employed in sensing and spectroscopy. The optical performance of the modes is evaluated in terms of sensing, like sensitivity and figure of merit, as well as near-field enhancement, like enhancement factor and field confinement. Our numerical investigation reveals that, in general, an increase in oscillator strength enhances the performance of the surface excitonic modes while a broadening degrades that as a counteracting effect. Most of all, this demonstrates that the optical performance of an excitonic system is tunable via molecular concentration unlike the plasmonic systems. Moreover, different surface excitonic modes show different degrees of tunability and equivalency in performance when compared to plasmons in gold. Our findings provide crucial information for developing and optimizing novel excitonic nanodevices for contemporary organic nanophotonics.
Density functional theory study of hydrophobic zeolites for the removal of triclosan from aqueous solution
Authors: Fischer Michael
Published: May 2023

The chlorinated biphenyl ether triclosan (TCS), used as a disinfectant in health care settings and in various personal care products, is an emerging organic contaminant of significant concern. Adsorption-based methods have been proposed as one potential pathway for the removal of TCS from wastewaters. Hydrophobic high-silica zeolites could constitute suitable adsorbent materials for such applications. In order to gauge the impact of pore size, topology, and framework composition, the adsorption of TCS in six different all-silica zeolites (AFI, BEA, CFI, FAU, IFR, MOR frameworks) and two highly siliceous protonated zeolites (H-FAU, H-MOR) was investigated using dispersion-corrected density functional theory (DFT). While pore size was found to affect the interaction strength, the rather flexible TCS molecule can adjust to different pore shapes, resulting in very similar adsorption energies for most all-silica zeolites. Although the interaction with TCS is enhanced in protonated zeolites, the affinity towards water increases even more. In DFT-based molecular dynamics simulations of TCS and water co-adsorption, H2O molecules quickly replace TCS in the vicinity of the framework protons, deprotonating the framework and forming positively charged clusters. In addition to delivering atomic-level insights into TCS adsorption, the calculations indicate that a fine-tuning of pore size with a concurrent maximization of hydrophobicity should constitute a promising strategy to develop optimized zeolite adsorbents for TCS removal.
Visible Light-Induced Palladium-Carbon Bond Weakening in Catalytically Relevant T-Shaped Complexes
Authors: Waddell Peter , Tian Lei , Scavuzzo Anthony , Scholes Gregory , Carrow Brad
Published: May 2023

Triggering one-electron redox processes during palladium catalysis holds the potential to unlock new reaction mechanisms and synthetic methods not previously accessible in the typical two-electron reaction manifolds that dominate palladium catalysis. We report that T-shaped organopalladium(II) complexes coordinated by a bulky monophosphine, a class of organometallic intermediate featured in a range of contemporary catalytic reactions, undergo blue light-promoted bond weakening leading to mild and efficient homolytic cleavage of strong Pd(II)–C(sp3) bonds under ambient conditions. The origin of light-triggered radical formation in these systems, which lack an obvious ligand-based chromophore (i.e., π- systems), was investigated using a combination of DFT calculations, photoactinometry, and transient absorption spectroscopy. The available data suggest T-shaped organopalladium(II) complexes manifest unusual blue light-accessible Pd- to-C(sp3) metal-to-ligand charge transfer (MLCT). The quantum efficiency and excited state lifetime of this process were unexpectedly superior compared to a prototypical (α-diimine)Pd(II) complex featuring a low-lying, ligand-centered LUMO (π*). These results suggest coordinatively-unsaturated organopalladium(II) compounds, catalysts in myriad catalytic processes, have untapped potential for one-electron reactivity under visible light excitation.
Carbothermal reduction reaction as a strategy for boosting thermoelectric performance of binary metal oxides: a case study of ZnO ceramics
Authors: Farahi Alireza
Published: May 2023

As a powerful concept, grain boundary (GB) engineering has been increasingly applied to enhance the energy conversion efficiency in thermoelectric materials through directly controlling the electrical and thermal transport characteristics. However, most efforts thus far have been focused solely on introducing extrinsic defects or impurity phases into the system without considering the role of intrinsic defects as critical factors. Thus, herein, we provide a holistic discussion on the correlation between the intrinsic defects and thermoelectric properties of materials using the carbothermal reduction (CTR) process. Taking ZnO as an example material, we experimentally show that vacancy-assisted migration of Zn interstitials lead to a decrease in the Schottky barrier height at grain boundaries. In addition, increasing the carrier concentration and band gap narrowing caused by the CTR reaction can lead to power factors up to 246 μW/mK2, which is comparable to the excellent values of transition metal-doped ZnO compounds. By minimizing the specific contact resistance of the interfaces down to 12.7 mΩ cm2 at a clamping pressure of 20 MPa, the output power of a single-leg module reaches an outstanding value of 292 μW at ΔT = 65 K, which is extremely higher than those of the state-of-the-art ZnO based materials, almost by a factor of three. We believe that the current study manifests a cost-effective avenue toward the development of efficient and practical thermoelectric devices.
The Role of Entropy on the Electrochemistry of Entropy-Stabilized Oxides and Their Lithium Storage Mechanism
Authors: Tegomoh Modeste , Lorie Lopez Jose , Cui Zhihao , Grandinetti Philip , Co Anne
Published: May 2023

Micrometer-size particles of entropy-stabilized transition metal-based high entropy oxide, (MgCoNiCuZn)O, has demonstrated long-term cycling stability against lithium-ion battery, a feat that has only been achieved with nanometer-size transition metal binary oxides. This electrochemical performance has been attributed to the entropy stabilization effect observed in this material. This work demonstrates that entropy stabilization might not play a role in the electrochemical performance of this compound as previously suggested, by comparing the electrochemical data of two medium entropy materials, (MgNiCuZn)O and (CoNiCuZn)O, with that of the high entropy material. In addition, the mechanism of lithium interaction with these materials is still poorly understood, in part owing to the difficulties in characterizing structure at the nanoscale. Solid-state operando NMR/derivative operando techniques are used to demonstrate that the lithiation of these compounds proceeds via a partially reversible conversion-type reaction involving the reduction of the transition metals cations to their metallic form during lithiation and the oxidation of these individual metal particles to their oxides form, losing the initial single-phase compound after the first lithiation cycle. The NMR results also show that the conductive carbon black used as an electronic conductor can store a significant amount of charge at low voltage, indicating that it is a major contributor to the additional observed in these entropy-stabilized oxides and in transition metal salts.
Understanding Sensitivity and Cross-Reactivity of Xylazine Lateral Flow Immunoassay Test Strips for Drug Checking Applications
Authors: Sisco Edward , Nestadt Danielle F. , Bloom Madeline B. , Schneider Kristin E. , Elkasabany Rae A. , Rouhani Saba , Sherman Susan G.
Published: May 2023

The continued prevalence of xylazine in the illicit drug market has necessitated the development of quick and simple methods for identification of adulterated materials. One method that could be employed is lateral flow immunoassays (also known as test strips), which are similar to those frequently used to determine the presence of fentanyl. In this work, we explored the use of xylazine test strips (XTS) for the detection of xylazine in drug residue samples and investigated their sensitivity and cross-reactivity. XTS were found to detect xylazine at concentrations as low as 0.5 µg/mL in solution and consistently produced a positive result at concentrations as low as 2.5 µg/mL. Cross-reactivity with other α2-agonists, α2-antagonists, commonly encountered drugs and cutting agents, and other structurally similar compounds was minimal, with lidocaine being the only compound of the 77 studied to illicit a positive response. When XTS were used to detect xylazine in real-world drug residue samples, xylazine was consistently detected in samples where the concentration was above 2 µg/mL and mixed results were obtained when the concentration ranged between 0.1 µg/mL and 2 µg/mL. When considering samples that were negative for xylazine or had xylazine present at a concentration above the 1 µg/mL cut-off, an overall accuracy of 98.6% was achieved.
Charged Chiral Derivatization for Enantioselective Imaging of D-, L-2-Hydroxyglutaric Acid Using Ion Mobility Spectrometry/Mass Spectrometry
Authors: Sugiyama Eiji , Nishiya Yuki , Yamashita Kenji , Hirokawa Ryo , Iinuma Yoshiteru , Nirasawa Takashi , Mizuno Hajime , Hamashima Yoshitaka , Todoroki Kenichiro
Published: May 2023

A newly synthesized charged chiral tag enabled enantioselective imaging of D-, L-2-hydroxyglutaric acid, which are independently associated with the regulation of DNA methylation. The tag-conjugated diastereomers were ionized efficiently through MALDI, separated by ion mobility spectrometry, and further separated from other molecules in mass spectrometry. On-tissue chiral derivatization using the tag facilitated the visualization of different distributions of the two isomers in the mouse testis.
Synthesis and Structural Characterization of Branched Bimetallic AuPd Nanoparticles with highly tunable optical response
Authors: Nuti Silvia , Fernández-Lodeiro Adrian , Chinchilla Lidia Esther , Hungria Ana Belen , Capelo Martinez Jose Luis , Lodeiro Carlos , Fernández-Lodeiro Javier
Published: May 2023

Bimetallic nanostructures composed of gold (Au) and palladium (Pd) have garnered increased interest for their application in heterogeneous catalysis. This study reports a simple strategy for manufacturing Au@Pd bimetallic branched nanoparticles (NPs), which offer a tuneable optical response, using polyallylamine-stabilized branched AuNPs as template cores for Pd over-growth. The palladium content can be altered by manipulating the concentration of PdCl42- and ascorbic acid (AA) that are injected, which permit an overgrowth of Pd shell up to ca. 2 nm thick. The homogeneous distribution of Pd at the surfaces of Au NPs can be carried out regardless of their size or branching degree, which allows an adjustment of the plasmon response in the near-infrared (NIR) spectral range. As proof of concept, the nano-enzymatic activity of pure gold and gold-palladium NPs was compared, exploring their Peroxidase-like activity in the oxidation of TMB. The bimetallic AuPd nanoparticles demonstrate an increase in catalytic properties attributed to the presence of palladium at the surface of gold.
On two resolvent matrices of the truncated Hausdorff matrix moment problem
Authors: Choque-Rivero A. E. , Medina-Hernandez B. E.
Published: May 2023

We consider the truncated Hausdorff matrix moment problem (THMM) in case of a finite number of even moments to be called non degenerate if two block Hankel matrices constructed via the moments are both positive definite matrices. The set of solutions of the THMM problem in case of a finite number of even moments is given with the help of the block matrices of the so-called resolvent matrix. The resolvent matrix of the THMM problem in the non degenerate case for matrix moments of dimension $q\times q$, is a $2q\times 2q$ matrix polynomial constructed via the given moments.

In 2001, in [Yu.M. Dyukarev, A.E. Choque Rivero, Power moment problem on compact intervals, Mat. Sb.-2001. -69(1-2). -P.175-187], the resolvent matrix $V^{(2n+1)}$ for the
mentioned THMM problem was proposed for the first time. In 2006, in [A. E. Choque Rivero, Y. M. Dyukarev, B. Fritzsche and B. Kirstein, A truncated matricial moment problem on a finite interval,
Interpolation, Schur Functions and Moment Problems. Oper. Theory: Adv. Appl. -2006. - 165. - P. 121-173], another resolvent matrix $U^{(2n+1)}$ for the same problem was given.
In this paper, we prove that there is an explicit relation between these two resolvent matrices of the form $V^{(2n+1)}=A U^{(2n+1)}B$, where $A$ and $B$ are constant matrices. We also focus on the following difference:
For the definition of the resolvent matrix $V^{(2n+1)}$, one requires an additional condition when compared with the resolvent matrix $U^{(2n+1)}$ which only requires that two block Hankel matrices be positive definite.

In 2015, in [A. E. Choque Rivero, From the Potapov to the Krein-Nudel'man representation of the resolvent matrix of the truncated Hausdorff matrix moment problem, Bol. Soc. Mat. Mexicana. -- 2015. -- 21(2). -- P. 233--259], a representation of the resolvent matrix of 2006 via matrix orthogonal polynomials was given. In this work, we do not relate the resolvent matrix $V^{(2n+1)}$ with the results of [A. E. Choque Rivero, From the Potapov to the Krein-Nudel'man representation of the resolvent matrix of the truncated Hausdorff matrix moment problem, Bol. Soc. Mat. Mexicana. -- 2015. -- 21(2). -- P. 233--259]. The importance of the relation between $U^{(2n+1)}$ and $V^{(2n+1)}$ is explained by the fact that new relations among orthogonal matrix polynomials, Blaschke-Potapov factors, Dyukarev-Stieltjes parameters, and matrix continued fraction can be found. Although in the present work algebraic identities are used, to prove the relation between $U^{(2n+1)}$ and $V^{(2n+1)}$, the analytic justification of both resolvent matrices relies on the V.P. Potapov method. This approach was successfully developed in a number of works concerning
interpolation matrix problems in the Nevanlinna class of functions and matrix moment problems.
On relation between statistical ideal and ideal generated by a modulus function
Authors: Seliutin D.
Published: May 2023

Ideal on an arbitrary non-empty set $\Omega$ it's a non-empty family of subset $\mathfrak{I}$ of the set $\Omega$ which satisfies the following axioms: $\Omega \notin \mathfrak{I}$, if $A, B \in \mathfrak{I}$, then $A \cup B \in \mathfrak{I}$, if $A \in \mathfrak{I}$ and $D \subset A$, then $D \in \mathfrak{I}$. The ideal theory is a very popular branch of modern mathematical research. In our paper we study some classes of ideals on the set of all positive integers $\mathbb{N}$, namely the ideal of statistical convergence $\mathfrak{I}_s$ and the ideal $\mathfrak{I}_f$ generated by a modular function $f$. Statistical ideal it's a family of subsets of $\mathbb{N}$ whose natural density is equal to 0, i.e. $A \in \mathfrak{I}_s$ if and only if $\displaystyle\lim\limits_{n \rightarrow \infty}\frac{\#\{k \leq n: k \in A\}}{n} = 0$. A function $f:\mathbb{R}^+ \rightarrow \mathbb{R}^+$ is called a modular function, if $f(x) = 0$ only if $x = 0$, $f(x + y) \leq f(x) + f(y)$ for all $x, y \in\mathbb{R}^+$, $f(x) \le f(y)$ whenever $x \le y$, $f$ is continuous from the right 0, and finally $\lim\limits_{n \rightarrow \infty} f(n) = \infty$. Ideal, generated by the modular function $f$ it's a family of subsets of $\mathbb{N}$ with zero $f$-density, in other words, $A \in \mathfrak{I}_f$ if and only if $\displaystyle\lim\limits_{n \rightarrow \infty}\frac{f(\#\{k \leq n: k \in A\})}{f(n)} = 0$. It is known that for an arbitrary modular function $f$ the following is true: $\mathfrak{I}_f \subset \mathfrak{I}_s$. In our research we give the complete description of those modular functions $f$ for which $\mathfrak{I}_f = \mathfrak{I}_s$. Then we analyse obtained result, give some partial cases of it and prove one simple sufficient condition for the equality $\mathfrak{I}_f = \mathfrak{I}_s$. The last section of this article is devoted to examples of some modulus functions $f, g$ for which $\mathfrak{I}_f = \mathfrak{I}_s$ and $\mathfrak{I}_g \neq \mathfrak{I}_s$. Namely, if $f(x) = x^p$ where $p \in (0, 1]$ we have $\mathfrak{I}_f = \mathfrak{I}_s$; for $g(x) = \log(1 + x)$, we obtain $\mathfrak{I}_g \neq \mathfrak{I}_s$. Then we consider more complicated function $f$ which is given recursively to demonstrate that the conditions of the main theorem of our paper can't be reduced to the sufficient condition mentioned above.
Two-point boundary value problem for systems of pseudo-differential equations under boundary conditions containing pseudo-differential operators
Authors: Makarov O. , Nikolenko I.
Published: May 2023

This paper deals with a two-point boundary value problem for pseudodifferential equations and for systems of second order pseudodifferential equations under boundary conditions containing pseudodifferential operators. The need to consider pseudodifferential operators is caused by two reasons, first, such equations appear more and more often in applied problems, and second, by considering such equations, it is possible to achieve the well-posedness of the boundary value problem in the Schwartz space S and in its dual space.First, we consider a scalar pseudodifferential equation with a symbol belonging to the space $C_{-\infty}^{\infty}$, consists of infinitely differentiable functions of polinomial growth. For this equation it is found of the boundary condition under which a specific type the boundary value problem is well-posed in the space S. In addition, an example of a differential-difference equation and a specific boundary condition with a convolution-type pseudo-differential operator under which this boundary value problem is well-posed in the space S are given.Then we consider a system of two pseudodifferential equations with symbols from the space $C _ {-\infty} ^ {\infty}$. For this system, we prove the existence of a well posed boundary value problem in the space S. The Fourier transform and the reduction of the system to a triangular form are used in the proof. In this case, we also give an example of a system and a specific boundary condition under which this boundary value problem is correct in the space S.Thus, the work proves that for any pseudo-differential equation, as well as for a system of two pseudo-differential equations, there is always a correct boundary value problem in the $S$ space, while the boundary conditions contain pseudo-differential operators. The algorithm for constructing correct boundary conditions is also indicated. They are pseudo-differential operators whose symbols depend on the symbols of pseudo-differential equations.
Homogeneous approximation for minimal realizations of series of iterated integrals
Authors: Andreieva D. M. , Ignatovich S. Yu.
Published: May 2023

In the paper, realizable series of iterated integrals with scalar coefficients are considered and an algebraic approach to the homogeneous approximation problem for nonlinear control systems with output is developed. In the first section we recall the concept of the homogeneous approximation of a nonlinear control system which is linear w.r.t.\ the control and the concept of the series of iterated integrals. In the second section the statement of the realizability problem is given, a criterion for realizability and a method for constructing a minimal realization of the series are recalled. Also we recall some ideas of the algebraic approach to the description of the homogeneous approximation: the free graded associative algebra, which is isomorphic to the algebra of iterated integrals, the free Lie algebra, the Poincar\'{e}-Birkhoff-Witt basis, the dual basis and its construction by use of the shuffle product, the definition of the core Lie subalgebra, which defines the homogeneous approximation of a control system. In the third section we show how to find the core Lie subalgebra of the systems that is a realization of the one-dimensional series of iterated integrals without finding the system itself. The result obtained is illustrated by the example, in which we demonstrate two methods for finding the core Lie subalgebra of the realizing system. In the last section it is shown that for any graded Lie subalgebra of finite codimension there exists a one-dimensional homogeneous series such that this Lie subalgebra is the core Lie subalgebra for its minimal realization. The proof is constructive: we give a method of finding such a series; we use the dual basis to the Poincar\'{e}-Birkhoff-Witt basis of the free associative algebra, which is built by the core Lie subalgebra, and the shuffle product in this algebra. As a consequence, we get a classification of all possible homogeneous approximations of systems that are realizations of one-dimensional series of iterated integrals.
Design and development of 1D torsional spring resonant scanner
Authors: Lim W. X. , Teh P. C. , Yew T. K.
Published: May 2023

This paper presents the design and dynamic response of a proposed non- Micro-Electro Mechanical Systems (MEMS) 1D torsional spring resonant scanner. The torsional spring was selected as the compliant structure of the device, and it was fabricated using aluminum with dimensions of 49 x 3.50 x 0.18 mm (L x W x T). An Analysis of Variance (ANOVA) test was performed to determine the difference in mean between the operating resonant frequency and the three types of materials, which are aluminum, stainless steel, and carbon steel. The device operates at a resonant frequency of 80.65 Hz, yielding a maximum scanning angle of 58.06 ˚. Hysteresis was observed from the frequency response chart of the system. By comparing the resonant frequency of the experimental results with the dynamic analysis of this device, the percentage error of the resonant frequency and optical scanning angle was found to be 6.67% and 16.84%, respectively.
INTERIM RESULTS OF THE IMPLEMENTATION OF THE NATIONAL PROJECT SMALL AND MEDIUM-SIZED ENTREPRENEURSHIP
Authors:   Ural State University of Economics (USUE), Loginov Mikhail P. , Rogachev Alexander S. ,   Ural State University of Economics (USUE)
Published: May 2023

The article analyzes the performance of the indicators of the national project «Small and medium-sized entrepreneurship and support for individual entrepreneurial initiative»: indicators for creating conditions for an easy start and comfortable business; indicators for creating favorable conditions for self-employed citizens to carry out activities through the application of a new taxation regime and the provision of support measures; indicators for the creation of a comprehensive acceleration system; indicators for creating a digital ecosystem focused on the needs of users — SMEs, self-employed citizens and individuals who want to start their own business; indicators for increasing the number of people employed in the field of small and medium-sized businesses, including individual entrepreneurs and self-employed, up to 25 million people. For each of the five blocks of indicators of the national project, the results were summed up and conclusions were drawn. At the end of the article, a general conclusion is given on the results achieved by the national project, problems are highlighted and recommendations are given for their elimination.
CURRENT TRENDS IN PROCESS CONTROL DIGITALIZATION OF THE FINANCIAL MARKET. PART II
Authors:   MGIMO University, Ershtukaeva Madina Z.
Published: May 2023

In the second part of the study of trends in regulating the process of digitalization of the financial market, the author considers the level of digitalization of the Russian financial market in the context of the priorities of its long-term development.The analysis of aggregated indicators (developed by the Bank of Russia) that determine the level and state of digitalization of the Russian financial market was carried out, and its priorities for long-term development were considered.Based on the results of the material of the second part, it was concluded that in the Russian Federation there is a forcing of modern trends in digitalization: the government of the country has adopted a number of regulations. Thus, the process of digitalization in Russia continues, and there are many prospects and barriers ahead to be overcome. This study consists of three parts.
Assessing the Influence of Augmented Reality in Mathematics Education: A Systematic Literature Review
Authors: Pahmi Samsul , Hendriyanto Agus , Sahara Sani , Muhaimin Lukman Hakim , Kuncoro Krida Singgih , Usodo Budi
Published: May 2023

One of the promising technologies to support the application of mathematics learning is augmented reality (AR). It is considered an important pedagogical tool that allows an increasing understanding of challenging ideas at most levels of education. This article presents the approach and concept of a systematic literature review (SLR) for reviewing the effects of AR in mathematics education. Filtering relevant material on AR and mathematics education from two databases (Scopus and Eric) to answer research questions is part of the review study. In the investigation, a total of 23 publications from 2018 to 2022 were systematically selected based on the PRISMA protocol. A review of the literature shows that interest in AR research has grown over time and is evenly distributed across different countries. The use of AR in mathematics education has been adopted and used as a supporting medium for interactive learning at various levels, from elementary school to college, that appears on the topics of geometry, algebra, basic mathematics, statistics and probability, and other mathematical topics. The effectiveness of AR, which is widely developed by researchers, is its ability to overcome existing problems, such as learning barriers, mathematical anxiety, and other cognitive problems. This review has filled and amplified the literature on AR on the effectiveness of AR in school mathematics learning. We recommend that in the future research on AR should focus on exploring the broad uses and long-term impacts of AR development and implementation on mathematics learning.
A Study on the Educational Experiences of Environmental Education Instructors
Authors:   Koreanisch-Deutsche Gesellschaft Fuer Erziehungswissenschaft, Cheong Eun , Kim Mi Hyang
Published: May 2023

Environmental education aims to solve a variety of problems around all kinds of pending environmental issues. In South Korea, environmental education has developed in a dual system between school environmental education provided by environment teachers as part of the school's subject curriculums and social environmental education provided by environmental education instruction in the community outside the school. Today school environmental education has shrunk considerably while needs for environmental education in the community grow day by day. In this situation, environmental education instructors outside the school provide students with environmental education by visiting schools themselves as well as in the community outside the school, covering most of practical environmental education for students. In the area of education, there have been no full researches on environmental education outside the school and especially environmental education instructors providing the education. This study thus set out to investigate the educational experiences of environmental education instructors by selecting four environmental education instructors as research participants and conducting an in-depth interview with them in June~September, 2021.
The findings show that environmental education instructors took various chances to begin providing education and there was a high degree of diversity in the content of education and the aspects of growth through educational experiences among the instructors. These findings once again demonstrated the value of diversity that environmental education should guarantee. The environmental education instructors all made many efforts to provide the right education on all sorts of discriminating environmental matters while pursuing diversity. A high level of spontaneity demonstrated by the instructors in the process became an important foothold for their self-growth. The uniqueness of individual environmental education instructors was reflected on environmental education in various ways, and their enriched educational experiences added further diversity to their unique educational capabilities. These findings raise a need for social and educational supports to help the content and methods of environmental education develop in a productive manner in harmony with the uniqueness of environmental education instructors. It is also needed to provide institutional supports for the management of environmental education to guarantee diversity and flexibility like today and, at the same time, ensure systematic long-term education.
Determinant Factors Analysis of Turnover Intention in Y Generation at Bank Syariah Indonesia, Semarang City
Authors: Sartika Mila , Akhmad Farida
Published: May 2023

The banking business must be able to adjust to the ongoing technological advances by leveraging these advancements to keep up with innovation. A new generation is currently joining the workforce. Leaders of businesses should get ready to welcome the Y Generation into their sector or organization because it may present both an opportunity and a challenge for Indonesia’s future. Companies need to pay more attention to employee turnover rates because the Y Generation is associated with a relatively high desire to leave the workforce. An in-depth analysis of the impact of job engagement, work-life balance, and Y Generation rewards on turnover intention is the goal of this study. The researcher employed primary data in the form of a questionnaire to investigate this problem. Software SPSS version 26 was used for data analysis. Managers can utilize this information to address issues with employee turnover intention. The study’s findings show that the work engagement variable significantly reduces the likelihood of turnover. The work-life balance variable then significantly reduces the likelihood of turnover. The incentive variable also significantly influences turnover intention in the wrong direction.
Candiduria y COVID-19: Características microbiológicas y factores asociados
Authors: Pacheco-Sánchez Karen Anais , Dehesa-López Edgar , García-Vazquez Ruy Angesaul , Mo-Ye Guillermo , Garay-Dixon Yoideth María de los Angeles , Gutiérrez-Arzapalo Perla Yareli
Published: May 2023

Objetivo: Determinar las características microbiológicas y factores asociados y pronóstico de Candiduria en pacientes hospitalizados por COVID-19 en el Hospital Civil de Culiacán --- Material y métodos: Estudio observacional, retrospectivo, longitudinal. Tipo de estudio: Cohorte retrospectiva realizado en el Hospital Civil de Culiacán, México. Se incluyeron pacientes mayores de 18 años hospitalizados con el diagnóstico de COVID-19; se excluyeron a mujeres embarazadas y se eliminaron los pacientes con recolección incompleta de las variables estudiadas. --- Resultados: De los 341 pacientes hospitalizados por COVID-19, el 14.4% presentó candiduria, el 51% fueron del sexo femenino, con una edad media de 61.43 años. Candida albicans fue la especie mayormente aislada con un 57.1% de los casos. El uso de esteroides (OR 3.88) y de antibióticos (OR 5.16) fueron factores asociados a la presencia de candiduria. En cuanto a la mortalidad, se encontró la edad (OR 1.051), el daño renal agudo (OR7.302) y la candiduria (OR 3.89) como factores de riesgo asociados, mientras que el uso de esteroides (OR 0.48) redujo significativamente el riesgo de mortalidad. --- Conclusiones: La candiduria es una micosis frecuente en los pacientes hospitalizados. En nuestro hospital se demostró una frecuencia de 14.4%; los factores de riesgo asociados son similares a los estudios previamente realizados en pacientes hospitalizados por COVID-19 u otras causas. La importancia del estudio se dirige al control de factores de riesgo, para así reducir las complicaciones y su asociación con la mortalidad. Palabras clave: Candida, Candiduria, COVID-19, Micosis.
Effect of Attributions on Consumer Response to CSR Efforts with Consumer Trust as the Moderator
Authors: Gyver Samuel Dio , SeTin SeTin
Published: May 2023

This study aims to examine the effect of other and self-serving attributions on the consumer response to corporate social responsibility (CSR) efforts with consumer trust as the moderator. This study also examines the differences in perceptions between men and women in assessing the motives of CSR efforts. Data were collected through a questionnaire survey of 122 students at a private university in Bandung. Multiple linear regression, independent simple T-Test, and F test were used for data analysis. Results prove that other-serving attributions have a positive effect on consumer response to CSR efforts. Meanwhile, self-serving attributions have a negative effect on consumer response to CSR efforts. When moderated by consumer trust in the firm, other-serving attributions will increase the consumer response to CSR efforts, whereas self-serving attributions will further reduce the consumer response to CSR efforts. Differences in perceptions are found between men and women regarding the consumer response to CSR efforts. This study implies that the development of CSR efforts needs to consider attributions and consumer trust in the firm.
Environmental Reporting Practices in an Emerging Economy
Authors: Islam S. M. Faridul , Hossain Syed Zabid
Published: May 2023

The study aimed to recognize the environmental awareness of corporate entities by exploring the extent of their associated information reporting practices. The study also strived to learn the notable board characteristics that transform the environmental reporting practices of the listed companies in an emerging market economy. This quantitative study was based on annual reports of randomly selected 100 manufacturing companies listed on the Dhaka Stock Exchange. The research used a self-developed disclosure index linked to the environment to collect data for the study. The study revealed that the extent of average environmental reporting practices by the sampled companies was too low, which was only 14.48% of the disclosure index developed for this study. Moreover, 4% of the selected companies did not disclose any environmental information in their annual report for the fiscal year 2018–2019 . The most disclosed theme was the concern for the general environment, whereas the lowest was the environmental performance, which was between 25.83% and 6.2%. The study documented that no other board characteristics were highly significant and could positively explain the extent of corporate environmental reporting practices in Bangladesh, only the willingness to disclose by the board.
The Role of Green Entrepreneurship and Green Variables in Sustainable Development in the Culinary Sector in Indonesia: Early Days of the COVID-19 Pandemic
Authors: Yudawisastra Helin G. , Anwar Mokhammad , Nidar Sulaeman R. , Azis Yudi
Published: May 2023

The UN Sustainable Development Goals are among the crucial missions of countries worldwide, including Indonesia. Nevertheless, application of a production system does not guarantee sustainability, and the Indonesian government’s support for sustainability in the entrepreneurial sector is nonoptimal. This study investigates green entrepreneurship in Indonesia’s culinary sector in relation to sustainable development and green variables. Using a culinary sector survey based on the UNWTO and the Ministry of Tourism, this study references primary questionnaire data, applying a random sampling technique and structural equation modeling covariance with a sample of 270 respondents. The results indicate that the provision of green products affects sustainable development, regardless of respondents’ green entrepreneurship. While green products may affect sustainable development, directly or through green entrepreneurship, green design does not appear to affect sustainable development, and green entrepreneurship does not appear to support sustainable conditions. Environmentally friendly product design and production processes have generated multiple recyclable products; however, the culinary sector must be made aware of the entrepreneurial ecosystem surrounding culinary business governance and the concerns and practices of sustainable development. This study was conducted at the beginning of the COVID-19 pandemic and represents the conditions of the culinary sector during the pandemic.
Millennial Generation and Smartphone Purchase Intention
Authors: Asbar Yuli , Biby Sapna , Razif Razif , Siregar Widyana Verawaty
Published: May 2023

Smartphones are the most popular in use among the younger generation, with 81% of young people having their own phones. Smartphone technology, with its high functionality, certainly change the behavior of people, especially young adults as the frequent use of smartphones at this time. From the findings of young adult behavior change and the increasingly competitive issues between brands of smartphones, this research will identify the intentions of purchasing their smartphones. From the results of the above research can be concluded that the purchase of consumer influenced by brand image. The higher status of brand image, the more purchase intentions there are. The correlation between product knowledge and purchase intentions is known that consumer purchase intentions are influenced by the amount of product knowledge. Perceived of price as a moderator, from the statistical results can be concluded that when consumers buy better (high) on the suitability of prices to the products with higher brand image. Meanwhile, price conformity does not contribute to the correlation between product knowledge and buyer intentions.
Investigation of the Mediating Role of Consumer Boycott Participation Motives in the Effect of Consumer Cynicism on Consumer Boycott Behavior
Authors: KESER Ercan , SÖĞÜTLÜ Rabia
Published: May 2023

Consumer cynicism, it is explained by the distrust, dissatisfaction and unmet expectations that consumers feel towards businesses. Consumer boycott behavior is evaluated as a form of consumer behavior in marketing science. Consumer boycott participation motives are expressed as the motivations that enable consumers to participate in the boycott. The purpose of this study is to examine whether a significant mediating effect of consumer boycott participation motives in the effect of consumer cynicism on consumer boycott behavior. The research was carried out by using the questionnaire method with 401 consumers living in Erzurum. Arithmetic mean, standard deviation, frequency distribution, reliability analysis, variance analysis, confirmatory factor analysis, exploratory factor analysis and structural equation analysis were used in the analysis of the data obtained in this research. Lisrel 8.51 and SPSS 22.0 statistical software packages were used in the analysis. The reliability and confirmatory factor analyses showed that the research variables had a high degree of reliability and the goodness-of-fit values were within acceptable limits. In the research, it has been determined that consumers have quite high levels of consumer cynicism, consumer boycott behavior and consumer boycott participation motives. As a result of the structural equation analysis carried out in the research, it is seen that the variables of making a difference and self-enhancement among the consumer boycott participation motives have a significant mediating effect on the effect of consumer cynicism on consumer boycott behavior. However, it was determined that the counter-arguments did not have a significant mediating effect.
Процес формування колективів різнорідних безпілотних літальних апаратів у сучасному бою
Authors: Кучеренко Ю. Ф. , Власік С. М. , Сізон Д. О. , Бєлоус М. В. , Бєлоус Н. М.
Published: May 2023

У статті наведені деякі характерні риси сучасних конфліктів (війн); показано, що головним завданням при веденні сучасних війн є завоювання і утримання інформаційної переваги над противником за рахунок використання єдиного інформаційно-комунікаційного простору міжвидовими угрупованнями військ, які спроможні вести бойові дії одночасно у декількох сферах (повітряному просторі, землі, морі і в інформаційному просторі (кіберпросторі)). Визначено, що головним напрямком подальшого розвитку застосування безпілотних літальних апаратів при веденні мережецентричних операцій, як одних з головних елементів повітряної компоненти, є комплексне їх застосування в системах розвідки, зв’язку, навігації та ударних комплексах. Показано, що в перспективі роль безпілотних літальних апаратів при веденні мережецентричних операцій буде збільшуватись и приведе до їх масованого, інтегрального та глобального застосування у вигляді різних колективів формувань, де головною метою буде формування інформаційного розвідувально-бойового простору і його подальше використання різними органами управління в процесі управління військами та засобами, а також забезпечення одночасного вирішення багатьох задач в інтересах міжвидових угруповань військ на різних рівнях управління. Даний матеріал доцільно використовувати в період підготовки та ведення сучасних бойових дій в процесі формування відповідних бойових груп (колективів) безпілотних літальних апаратів для виконання ними комплексних завдань у певних зонах, з метою більш повного використання своїх бойових можливостей різними міжвидовими угрупованнями військ.