bluuebunny/crossref_metadata_2025 huggingface dataset:
Patient "GRIT" Does Not Predict Pain and Opioid Consumption Following Total Knee Arthroplasty
Authors: Keller Sydney , Seetharam Sachin , Ziemba-Davis Mary , Meneghini, MD R. Michael
Published: October 2019

Background and Hypothesis: TKA results in severe postoperative pain and differential needs for narcotics. Medical covariates of pain and opioid use following TKA have been investigated, but the influence of personality has not. GRIT consists of passion/consistency of interest in goals and perseverance of effort. Perseverance has been associated with beneficial autonomic nervous system activity. GRIT has been associated with independence in activities of daily living, decreased depression/anxiety, and increased well-being in chronically ill patients. We evaluated whether GRIT modulates pain and opioid consumption following TKA, hypothesizing that higher GRIT scores would be associated with lower pain and opioid consumption.
Project Methods: The GRIT survey was retrospectively administered to 254 consecutive patients with cemented TKAs performed between 2016 and 2018 by a single surgeon using the same pain protocols and implant. Results were paired with prospectively collected average pain score during the first 24 hours following PACU discharge, average pain during the remainder of hospital stay, final pain score prior to discharge, time to first opioid medication after PACU discharge, total opioid consumption in morphine equivalents (MEQs) during the first 24 hours after PACU, and average MEQs/day during the remainder of stay.
Results: The sample was 71% female with average age of 67.5±8.3 years and average BMI of 33.7±7.2 kg/m2. Coefficient r for pain metrics and passion, perseverance, and GRIT ranged from -0.145 to 0.078 (p≥0.146) with the exception of a small (0.136), but significant (p=0.032) correlation between final pain score and perseverance. r for opioid metrics and passion, perseverance, and GRIT ranged from -0.039 to 0.087 (p≥0.172).
Conclusion and Potential Impact: Mean GRIT scores ranged from 3.7-4.3 with a median range of 3.8-4.3, suggesting demand characteristics associated with the instrument. Post hoc statistical power was low (≈35%) given n and small effect sizes. It is hoped, however, that our study fosters investigation of individual characteristics and important clinical outcomes.
Impact of IVC Filter Guidelines, Registry, and Clinic on Filter Retrieval.
Authors: Kiley, BS Brandon , Hollister, MSN, RN Lisa , White, MD T. Eric , Keltner, BS, MA Emily , Zhu,  MBBS, FACE, FRCP Thein , Opoku, MPH Dazar
Published: October 2019

Background and hypothesis: Deep vein thrombosis (DVT) and pulmonary embolism (PE), collectively referred to as venous thromboembolism (VTE), are serious medical conditions that affect up to 900,000 Americans yearly, accounting for up to 100,000 deaths. The first line treatment for VTE is anticoagulation; however, in patients who experience a contraindication to, or failure of anticoagulation, an IVCF may be used. There are two types of IVCFs, permanent and retrievable. Retrievable filters are indicated when the contraindication to anticoagulation is transient, and they may be removed once the contraindication has passed. Retrievable filters have become associated with serious complications such as filter fracture, migration, and IVC perforation. Subsequently, they have become the subject of litigation. As such, strategies should be undertaken to reduce filter dwell time and improve filter retrieval rates. We hypothesize that implementation of IVCF guidelines, registry, and clinic will reduce dwell time while increasing retrieval rate.
Methods: This study was a mixed retrospective and prospective chart review of patients who received an IVCF before and after implementation of IVCF guidelines, registry, and clinic. The guidelines, registry, and clinic were established in July 2017. Cases were analyzed during the years 2014-2015 (n=191) and 2017-2018 (n=103) beginning in July 2017. Data was obtained on filter retrieval rate, dwell time, filter-associated complications, and indication for placement.
Results: There was a significant decrease in dwell time (p<.001) and a significant increase in retrieval rate (p<.001). There was no difference in complication rate, and there was a decrease in filter placement in patients with ‘soft’ indications, though this difference was not statistically significant (p=.109).
Conclusion and potential impact: Implementation of dedicated efforts to increase patient follow-up and filter retrieval were effective in reducing dwell time and retrieval rate. Although there was no significant difference in complication rate, these efforts may be protective against litigation for patients who experience a filter-associated complication.
QPCR and Western Based Fitness Index for Exercised Mice
Authors: Lee Zachary , Vargas Stephanie , Schroeder Bradley , Foley John
Published: October 2019

Physically fit humans exhibit resistance to infectious and sedentary lifestyle diseases, as well as cancer. This resistance is mediated by alterations in the immune microenvironment. To identify mechanisms, mouse models of exercise have been used. As it has become clear that mice have a natural desire to exercise, voluntary running wheels have become the dominant exercise method eclipsing forced exercise models. To precisely record duration and intensity of exercise, mice are often singly housed with running wheels which induces stress. This project seeks to establish a quantitative molecular and biochemical fitness index for individual mice group housed with access to voluntary running wheels to correlate with disease measures. The gastrocnemius, quadriceps, and soleus muscles were dissected from exercised mice and their controls. These muscles were subject to qPCR for TNNI1 and TNNI2 transcripts, indicators of slow and fast twitch muscles, respectively. Further, the hearts were cut into superior and inferior halves and evaluated by qPCR for the genes NPPA and ATP2A2, indicators of left ventricle thickening. Lastly, a western blot evaluated p70 S6 kinase, another marker of ventricle adaption. Voluntary wheel exercised older mice failed to increase TNNI1 mRNA in the gastrocnemius and quadriceps, indicating the absence of fiber remodeling. In contrast, increased ATP2A2 transcripts were observed in the hearts. Also, increased phosphorylated form of p70 S6 were observed in voluntary exercised mice. Together these findings suggest that voluntary exercise in a group housing setting produces cardiac adaption, but may not induce the changes in skeletal muscle reported with forced exercise. This methodology will be applied to future studies where the impact of voluntary and forced exercise on immune markers and tumor growth are studied.
Organizational Culture Drives Confidence in Implementing Telestroke Care
Authors: Miao Christopher , Martin, MPH Holly , Damush, PhD Teresa , LaPradd, MS Michelle , Ofner, MS Susan , Williams, MD Linda
Published: October 2019

Background and Hypothesis: During the past two years, the Veteran Affairs’ National Telestroke Program (NTSP) has conducted 800 teleconsultations at 30 participating sites. Site perceptions of the NTSP are collected in surveys at the time of the program entry and 6-12 months later. This study aims to determine factors associated with the confidence in providing stroke care among staff at participating hospitals, and whether confidence is associated with site performance on program quality indicators.
Experimental Design: Web-based surveys were sent to participating sites at baseline and post implementation. Survey questions pertained to a site’s confidence providing stroke care, organizational readiness to change (ORCA assessment), buy-in of clinical services, and the impact of the program. Individual responses were averaged at each site. Confidence was scored from zero to ten and was dichotomized into fully confident (10) and not fully confident sites (<10). Site performance on key indicators of program quality were obtained from the NTSP data. A Kruskal Wallis analysis examined the association of baseline variables with postimplementation confidence.
Results: 54 individuals (57% nurses, 26% providers, and 7% administrators) from 16 sites had baseline and post-implementation data. Five sites were fully confident at the postimplementation assessment. The other 11 had confidence scores ranging from 8.32 to 9.5. Higher ORCA scores were significantly associated with post-implementation confidence (mean ORCA 12.2 vs. 6.8, p=0.04). Sites with longer NTSP participation were less likely to be fully confident, (mean 10.6 months vs. 3.8, P=0.01). Baseline confidence, rurality, and volume were not associated with post-implementation confidence, nor was post-implementation confidence associated with measurements of site performance.
Conclusion: Higher ratings of site organizational culture was associated with higher postimplementation confidence in providing stroke care. This suggests that an individual site’s context is a larger driver of the confidence in program implementation than volume or program performance. In addition, the finding that sites with longer time spent in the NTSP had lower post-implementation confidence suggests sites may benefit from periodic retraining to sustain confidence in their ability to provide stroke care.
A Rare Case of Unilateral Foix-Chavany-Marie Syndrome
Authors: Raab Courtney , Chaudhry, MD Farrukh
Published: October 2019

Background: Bilateral anterior opercular syndrome, or Foix-Chavany-Marie Syndrome (FCMS), is a neurological condition characterized by bilateral anterior opercular lesions. Common presenting symptoms of this rare suprabublar palsy include dysarthria, or slurred speech, as well as paralysis of facial, pharyngeal, lingual, and masticatory voluntary muscles while autonomic function is preserved.1 Most cases of FCMS are bilateral, yet some rare cases have been reported with unilateral opercular lesions with preexisting contralateral white matter lesions.2 In this case report we present a rare case of unilateral FCMS in a patient who had an acute anterior left opercular infarct, as well as a residual right parietal subcortical stroke.
Project Methods: The patient we present is a 49 year old African American female with a history of hypertension and previous stroke with residual spastic right hemiplegia who presented to the ED for evaluation of right sided facial droop, right sided weakness, and slurred speech. Patient was evaluated by acute stroke team and was treated with intravenous thrombolysis (Alteplase). On hospital day 2, the patient developed complete disarticulation, unable to produce any speech but able to communicate by appropriate gestures and writing. The patient’s symptoms included anarthria, weakness of bilateral masseters, and lateral/medial pterygoids without dysphagia. Results: The MRI brain showed left insular region/frontal opercular ischemic stroke and a small right parietal subcortical ischemic stroke, likely embolic in nature. Over the hospital stay, the patient’s motor function improved but her anarthria persisted. These radiologic findings along with the symptomology proved consistent with FCMS. She was discharged to home with an NIH stroke scale of 5 and recommended outpatient speech therapy.
Conclusion: In this case report, we describe a patient that presents with an extremely rare case of unilateral FCMS, with a preexisting contralateral parietal infarct that could have collectively caused anarthria and masseter weakness.
 
Works Cited 1. Milanlioglu A, Aydın MN, Gökgül A, Hamamcı M, Erkuzu MA, Tombul T. Ischemic Bilateral Opercular Syndrome. Case Reports in Medicine. 2013;2013:1-3. doi:10.1155/2013/513572.
2. Sa F, Cordeiro IM, Mestre S, Nzwalo H. Unilateral opercular infarction presenting with FoixChavany-Marie syndrome. Case Reports. 2014;2014. doi:10.1136/bcr-2014-206439.
Augmenting nab-paclitaxel/gemcitabine standard chemotherapy response by merestinib, an inhibitor of c-MET, Axl and DDR signaling pathways, in preclinical pancreatic cancer models
Authors: Shi Eda
Published: October 2019

Background and Hypothesis: Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies in Western countries. Nab-paclitaxel (NPT) plus gemcitabine (Gem) is the standard of care for PDAC leading to a dismal 8.5 months median survival. Aberrant signaling of c-MET, Axl and DDR have been reported in a variety of human cancers including PDAC. Merestinib (Mer) is a potent, smallmolecule inhibitor of these pathways. We evaluated the therapeutic efficacy of merestinib to enhance the antitumor response of standard chemotherapy in preclinical models of PDAC.
Project Methods: Cell proliferation of PDAC-associated cells (AsPC-1, PANC-1 and fibroblasts) were evaluated by colorimetric WST-1 assay. Protein expression was determined by Western blot analysis. Tumor progression studies were performed in NOD/SCID mice.
Results: In vitro studies demonstrated that both nab-paclitaxel plus gemcitabine and merestinib suppressed cell proliferation of PDAC epithelial cells and stromal cells. Importantly, the combination treatment demonstrated additive inhibitory effects. In AsPC-1 cells, at the medium dose level, NPT+Gem, Mer and NPT+Gem+Mer treatments inhibited cell proliferation by 53.9%, 13.5%, and 81.61%, respectively. In PANC-1 cells, at the highest dose level, inhibition in cell proliferation by NPT+Gem, Mer and NPT+Gem+Mer treatments was 53.6%, 3.7%, and 72.8%. In the PDAC-associated fibroblasts, at the medium dose level, NPT+Gem, Mer and NPT+Gem+Mer treatments inhibited growth by 55.3%, 58.0%, and 91.6%. Immunoblot analysis revealed that merestinib caused a decrease in the PI-3K-AKT signaling proteins and an increase in apoptosisrelated proteins cleaved PARP-1 or cleaved caspase-3 in PDAC cells either alone or in combination with nab-paclitaxel and gemcitabine. In vivo study to evaluate tumor growth inhibition effects of merestinib in a subcutaneous PDAC xenograft is currently ongoing.
Conclusion: The antitumor effect of standard chemotherapy regimen can be significantly enhanced by the cMET/Axl/DDR pathway inhibitor merestinib, which may lead to clinically relevant therapeutic strategy to increased survival in PDAC patients.
Explicaciones Geométrico-Diagramáticas en Física desde una Perspectiva Inferencial
Authors: Anta Javier
Published: October 2019

El primer objetivo de este artículo es mostrar que explicaciones genuinamente geométricas/matemáticas e intrínsecamente diagramáticas de fenómenos físicos no solo son posibles en la práctica científica, sino que además comportan un potencial epistémico que sus contrapartes simbólico-verbales carecen. Como ejemplo representativo utilizaremos la metodología geométrica de John Wheeler (1963) para calcular cantidades físicas en una reacción nuclear. Como segundo objetivo pretendemos analizar, desde un marco inferencial, la garantía epistémica de este tipo de explicaciones en términos de dependencia sintáctica y semántica del contenido  lo inferido en las premisas, lo cual denominaremos criterio de validez inferencial (CVI).
La agencia técnica animal: hacia una explicación de las conductas de uso y fabricación de herramientas
Authors: Mejía Rendón Joan Sebastián
Published: October 2019

En este trabajo examino la noción de “agencia” y su posible aplicación a la técnica animal. Aunque la teoría clásica de la acción considera que los animales no-humanos no pueden ser agentes debido a su ausencia de lenguaje, los estudios de caso centrados en la capacidad de uso y fabricación de herramientas sugieren que algunos animales pueden tener habilidades técnicas complejas. ¿Podrían los animales ser considerados agentes técnicos? En este trabajo propongo un modelo explicativo para entender la capacidad técnica de algunos animales como cuervos y chimpancés. Aplicando los conceptos de representación motora y planes de acción, defiendo la idea de que ciertos animales deben ser considerados como agentes técnicos en la medida en que éstos son capaces de usar y fabricar ciertas herramientas de acuerdo a planes mentales de acción. Esto se debe a que los animales son capaces de representar objetos y actuar en concordancia de sus representaciones mentales, a pesar de no poseer un lenguaje articulado ni conceptos expresados proposicionalmente. Finalmente, concluyo que existe una técnica por fuera del ámbito humano.
Impact of plant-based natural extracts on pollutants and pathogens in the air
Authors: Bahl Amul S
Published: October 2019

Introduction: Air pollutants result in a number of health problems. These health setbacks may range from minor respiratory troubles to chronic effects on human health like asthmatic attacks. A product has been developed consisting of plant-based active nano extracts which is a simple, safe and effective solution to poor air quality by reducing pollutants and pathogens in the air. The aim of this paper is to study the impact of this product (in the form of the liquid solution - referred as ‘spray’) in improving the indoor air quality by reducing the PM, HCHO, and TVOC (Total Volatile Organic Compound) and pathogens. Materials and methods: The study was conducted in three phases in indoor environments in India. Phase1 was conducted in a controlled environment in a laboratory to study the impact of spray on air pathogens. Phase2 was conducted indoors in multi-scenario simulations, and Phase3 was done in a school principal room with reception area. Results: The study conducted in three phases supports the effectiveness of the spray to reduce air pathogens and the air pollutants viz., PM2.5, PM10, HCHO, and TVOC in indoor air environments. Conclusion: The spray will be an effective, safe, environment friendly and economical solution to reduce indoor air pollution to safe guard human health.
The trend of air quality index (AQI) in Tehran during (2011-2016)
Authors: Taghizadeh Farhad , Jonidi Jafari Ahmad , Kermani Majid
Published: October 2019

Introduction: Tehran city with the most population, about 4 million cars, million liters of fuels consumption, the presence of polluting industries such as petrochemicals and refineries, thermal power plants, and surrounding industrial towns is considered as one of the most populous and most polluted cities in the world . This study aims to investigate the trend of variation in air quality index in Tehran. Materials and methods: In this descriptive and evaluative study, the air quality data of 7 monitoring stations in 2012 were taken from the Tehran Department of Environment and Tehran Air Quality Control Company(AQCC). The calculation of AQI was done according to the EPA guidelines. Results: According to the results of this study, highest AQI averaging for 2016 (208.49±42.13) and the lowest for 2011 (134.13±46.80). Also observed that during the study period PM2.5 particles with an average of 71.59% is the most important factor in increasing the air quality index. Conclusion: It was observed that in the cold seasons of the year, due to the temperature inversion phenomenon in Tehran and the increase in the concentration of pollutants, air quality in most regions of Tehran is in unhealthy conditions, but in other season of the year the air quality is in moderate condition. Among the index pollutants, particulates are the major cause of Tehran’s air quality decline.
A review on effect of air pollutants on fetal development and pregnancy outcomes
Authors: Kashyap Rekha , Gupta Rajnish , Asif Mansuri Mahamad , Thasale Rupal
Published: October 2019

Developing fetus is connected to the mother by placenta to receive oxygen and nutrients. Maternal exposure to ambient air pollution not only affects maternal health but also provides a pathway for many toxic pollutants to cross the placental barrier and interrupt biochemical milieu. There are numerous scientific studies available describing possible negative health impact of air pollutants on reproductive health, pregnancy outcomes and fetal development yet no toxic effect is available recently. Studying the pollutants exposure effect on fetal development is crucial for the underlying mechanism between prenatal exposure and pregnancy outcomes. Present review meticulously provides the compiled data of 40 most recent studies with possible action mechanism of air pollutants on pregnancy outcomes and fetal development to find a better solution to exterminate or reduce the problem.
South African Undergraduate Health Science Students’ Knowledge, Attitudes, Practices and Preferences Regarding Vaccination
Authors: Le Roux Christine , Dramowski Angela
Published: October 2019

Background: South African universities lack comprehensive vaccination policies for undergraduate health science students, despite exposure to vaccine-preventable diseases during clinical training. We investigated health science students’ knowledge, attitudes and practices (KAP) of Stellenbosch University regarding vaccination and established their preferences for the delivery of a student vaccination programme.

Methods: A 32-question survey regarding students’ KAP and preferences about vaccination was emailed to undergraduate health science students (n = 2472) between November 2017 and April 2018. Mean KAP scores and vaccination preferences were compared between medical and allied health students. Responses to three open-ended questions were coded by two independent researchers to identify emerging themes.

Results: Questionnaires (n = 403) were completed by medical (79.8%) and allied health (20.2%) students. There was no difference between the mean K-scores of the two groups (6.8 vs 6.4/10 questions; p = 0.998). Students had positive attitudes to vaccination (mean A-score 4.1/7 questions) but felt that education regarding recommended vaccinations was lacking. Although students supported the idea of mandatory vaccinations, many raised concerns regarding access and affordability of vaccinations. The majority (90.3%) of students had completed or were completing their hepatitis B immunization series. There was widespread support for peer vaccination sessions and development of a webpage or mobile application to assist with scheduling of vaccinations.

Conclusions: Undergraduate health science students support the introduction of an expanded vaccination policy. Additional educational content, vaccine accessibility and affordability are important issues to consider in the development of a health science student vaccination programme.
ANALISIS TERHADAP FATWA DEWAN SYARI’AH NASIONAL MAJELIS ULAMA INDONESIA (DSNMUI) TENTANG UANG ELEKTRONIK SYARIAH (Studi Kartu Flazz BCA, Go-Pay, dan Grab-Pay)
Authors: Nengsih Novia
Published: October 2019

Technological developments have transformed the cash-money payment model into e-money, but the law on the use of e-money is still a debate in Indonesian Moslim society. This paper aims to analyze the legal use of e-money based on DSN-MUI fatwa No: 116/DSN-MUI /IX/2017 concerning Sharia Electronic Money. This research is a library research with descriptive analysis approach. E-money that was studied in this study was the BCA Flazz cards, Go-Pay, and Grab-Pay. Based on the Fatwa of MUI DSN on Shari’ah electronic money, the e-money system used in Indonesia today is not permitted because the issuer places the nominal amount of electronic money in conventional banks, if the card is lost the nominal amount of money in the issuer is also lost, and electronic money holders cannot be taken or cashed back.

Perkembangan teknologi telah mentransformasi model pembayaran dari cash-money menjadi e-money, tetapi hukum penggunaan e-money masih menjadi perdebatan di kalangan masyarakat Muslim Indonesia. Tulisan ini bertujuan untuk menganalisis hukum penggunaan e-money berdasarkan fatwa DSN-MUI No: 116/DSN-MUI/IX/2017 tentang Uang Elektronik Syariah. Penelitian ini merupakan penelitian kepustakaan (library research) dengan menggunakan pendekatan deskriptif analisis. E-money yang menjadi kajian dalam penelitian ini adalah kartu Flazz BCA, Go-Pay, dan Grab-Pay. Berdasarkan fatwa DSN MUI tentang Uang elektronik Syari’ah, maka sistem e-money yang dipakai di Indonesia hari ini tidak diperbolehkan karena penerbit menempatkan jumlah nominal uang elektronik di bank konvensional, apabila kartu hilang maka jumlah nominal uang yang ada di penerbit juga hilang, dan uang elektronik pemegang tidak bisa diambil atau diuangkan kembali.
PENGEMBANGAN INSTRUMEN EVALUASI KOMPETENSI SOFTSKILL MAHASISWA UNTUK MENGUKUR KESIAPAN DIRI MENGHADAPI DUNIA KERJA DI FITK UIN MAULANA MALIK IBRAHIM MALANG
Authors: Fitriah Nurlaeli
Published: October 2019

Competence of softskill both interpersonal and intra-personal competencies are associated with an attitude that is owned by an individual. A person's attitude will affect the acceptance of the individual in a social environment in which the individual resides. Is necessary for students to identify the extent of the environmental acceptability of the students themselves. It will be easier with the ability of students to evaluate and measure regularly softskill its competence through raw instrument developed in this study. The results showed students soft skill competency evaluation instrument to measure the readiness of students in the world of work has to be used as a tool or instrument that is reliable. This is demonstrated through expert validation test and field test. Of expert validation test validates 56 items of 72 items was developed. And the field test 55 items declared valid and reliable

Keywords: instrument, self-evaluation
PENGELOLAAN KEUANGAN MASJID SEBAGAI ORGANISASI NIRLABA
Authors: Kusumadyahdewi Kusumadyahdewi
Published: October 2019

The mosque is a non-profit institution, which organizes many religious, social, educational and da'wah activities. The activities held to depend on a lot of funds obtained from the community as a source of mosque funding. Based on the results of the study, the sources of mosque funding were obtained from charity boxes attached to the walls of the mosque consisting of the construction of mosques, infaq of mosques, those entitled to receive, orphans, and the poor. Also from the charity box during Friday prayers, regular and non-permanent donors. Based on the money obtained, the mosque held social activities, education, and da'wah. As the manager's responsibility to the public, monthly income and expenditure reports are always posted on the mosque's bulletin board so that all can see the report. Besides, it also sends special financial reports to regular donors. This financial transparency makes it easier for mosques to raise funds from the public. The preparation of the mosque's financial report involves the treasurer and daily staff, as is known by the chairman of the mosque's takmir as the person in charge. As a community organization, this mosque is also monitored directly by the public by publishing its financial statements.

Keywords: mosque; religion; social; education; da'wah
MEDIA PEMBELAJARAN BERBASIS AUDIO VISUAL DALAM MENINGKATKAN HASIL BELAJAR IPS TERPADU DI MTS NEGERI 1 PASURUAN
Authors: Rifandi Muhammad Sofi
Published: October 2019

The purposes of the research are: (1) To describe the implementation of the utilization of learning media of Integrated Social Studies Subjects of the Students of Class VII at Public Junior High School 1 of Pasuruan. (2) To know the learning result of the utilization of learning media Integrated Social Studies Subjects of the Students of Class VII at Public Junior High School 1 of Pasuruan. (3) To describe and explain the problems of the utilization of Integrated Social Studies Subjects of the Students of Class VII at Public Junior High School 1 of Pasuruan To achieve the objectives above, it had used descriptive qualitative approach for three months. The key instruments are the researcher, and the collection techniques used observation and interviews. Data can be used by reducing relevant data, exposing data and drawing conclusions. The results of the research showed that (1) the implementation of learning media utilization, the teacher uses audiovisual media using LCD at school, the teacher can use the learning media by using the photo or the video about the learning material that has been explained. (2) the student learning outcomes after utilizing the audiovisual media on integrated Social Science subjects are very well. The average student gets a lot of good results with a value of 8.5. (3) the supporting factors are the facilities of adequate infrastructure, motivation and work ethics of educators in using learning media based on audiovisual, the student’s discipline in following the teaching and learning activities in the class. The inhibiting factors are the lack of awareness of educators in the utilization of learning media based on audiovisual at school.

Keywords: audiovisual; learning outcomes
WONDERSHARE QUIZ CREATOR BERBASIS ANDROID DALAM MATA PELAJARAN SOSIOLOGI KELAS XI IPS 2 MAN 1 MALANG
Authors: Fadlullah Achmad Kholid
Published: October 2019

The quality of education is determined by the integration between all learning components such as teachers, pre-facility facilities, curriculum, learning methods, learning media. The use of media is an effort to overcome learning problems. The media functions as an intermediary between educators and students in conveying information. To achieve this goal, the researchers developed a media that is an Android-based Wonder share Quiz Creator evaluation media. The purpose of the research is 1) To describe the specifications of the evaluation media for Wonder share Quiz Creator based on Android in Sociology subjects in XI IPS 2 MAN 1 Malang. 2) To develop an Android-based Wonder share Quiz Creator evaluation media in Sociology subjects in XI IPS 2 MAN 1 Malang. 3) To describe the results of the development of an Android-based Wonder share Quiz Creator media evaluation in Sociology subjects in XI IPS 2 MAN 1 Malang. The research method uses Research and Development (R & D), referring to the model introduced by Borg and Gall. Techniques for collecting data through observation, tests, and questionnaires. Data analysis techniques used content analysis of learning and descriptive analysis. The results of this study indicate that: 1) Android-based Wonder share Quiz Creator evaluation media in sociology learning is an application containing’s a variety of questions, random in nature, can be used online and offline. 2) Wonder share Quiz Creator media evaluation which was initially web-based in the computer was developed into an Android-based application 3) this development proved useful, interesting and valid in, based on 80% sociology material validator data, 73% design experts, and IPS 2 student responses 82.57%. The increase in learning outcomes pre-test and post-test from the results of t-test, T table is 3.23> 1.68. This shows that the product developed has a high level of validity and high attractiveness, so it is suitable to be used in supporting the evaluation process.

Keywords: wonder share quiz creator; android; social science
La función académica extensionista desde la óptica de la Responsabilidad Social Universitaria
Authors: Cano-Angulo Leslie Yrisay
Published: October 2019

Este artículo expone un análisis acerca del papel de la función académica representada por la extensión en la Responsabilidad Social Universitaria (RSU) como elemento relevante del compromiso de las universidades vanguardistas con su entorno. La RSU está intrínsecamente arraigada a la obligación que tienen estas casas de estudio en dar respuestas certeras a las demandas de la sociedad, siendo consciente de los impactos que puedan producir. En principio se hace una disección conceptual sobre la extensión universitaria (EU) y sus dimensiones desde el punto de vista de algunos expertos en la materia y desde la concepción de un grupo selecto de universidades venezolanas, para posteriormente distinguirla desde la óptica de la RSU como uno de sus componentes necesarios para cumplir con parte de la misión de las universidades, orientada al compromiso en la búsqueda del bienestar y el desarrollo sustentable de la sociedad. Por último, se infieren algunas consideraciones finales a manera de reflexión relacionadas con el rol que debe asumir la EU como un baluarte de la academia que contribuye al fortalecimiento de la RSU.
La felicidad en el trabajo: entre el placer y el sentido
Authors: Porras Velásquez Néstor Raúl , Parra D’aleman Laura Camila
Published: October 2019

El objetivo de este artículo de investigación documental es presentar los elementos básicos de la propuesta de Martin Seligman en su libro La auténtica felicidad, y su contribución al campo de la psicología del trabajo y de las organizaciones, particularmente en lo relacionado con el bienestar, la satisfacción y la salud mental laboral. La metodología empleada fue el análisis documental. Los resultados muestran que el concepto de felicidad tradicionalmente se asocia con una experiencia placentera; sin embargo, la auténtica felicidad en el mundo del trabajo es una combinación de placer, compromiso y sentido de la actividad realizada. Las conclusiones evidencian que el fundamento de la felicidad en el trabajo es una elección subjetiva que va más allá del principio del placer.
Identifikasi Dan Prevalensi Infeksi Protozoa Saluran Cerna Babi Yang Dipotong Di Rumah Potong Hewan Denpasar
Authors: Widyasari Ni Nyoman Ayu , Apsari Ida Ayu Pasti , Dharmawan Nyoman Sadra
Published: October 2019

Tujuan dari penelitian ini adalah untuk menentukan jenis dan prevalensi protozoa gastrointestinal babi yang dipotong di Rumah Potong Hewan Denpasar. Sampel feses diambil langsung dari usus 100 babi saat babi dipotong, lalu dimasukkan kedalam tabung yang mengandung 2,5% kalium bicromate. Pemeriksaan dilakukan dengan menggunakan modifikasi metode gula sheater. Sampel diperiksa secara mikroskopis untuk mengetahui adanya kista atau ookista protozoa saluran pencernaan pada babi. Hasil yang diperoleh adalah 48 sampel (48%) terinfeksi protozoa. Setelah identifikasi protozoa tersebut adalah Coccidia dengan prevalensi 44% dan Giardia sp. dengan prevalensi 4%.
Pengaruh Penambahan Tepung Daun Kelor (Moringa oleifera) pada Pakan Tikus Putih Terhadap Aktivitas Enzim Alanin Aminotransferase dan Aspartate Aminotransferase
Authors: Setiyowati Asri , Utama Iwan Harjono , Setiasih Ni Luh Eka
Published: October 2019

Penelitian ini menggunakan 25 ekor tikus putih betina, masing-masing kelompok terdiri atas lima ekor tikus putih betina P0 (hewan coba diberikan pakan tanpa penambahan tepung daun kelor), P1 (pakan di tambahkan tepung daun kelor 2,5 %) P2 (pakan di tambahkan tepung daun kelor 5 %), P3 (pakan di tambahkan tepung daun kelor 10 %), P4 (pakan di tambahkan tepung daun kelor 20%). Hasil penelitian menunjukkan penambahan tepung daun kelor pada pakan dapat menurunkan nilai aktivitas enzim Aspartate aminotransferase dan Alanin aminotransferase. Tepung daun kelor (Moringa oleifera) dosis 20% mampu menurunkan nilai aktivitas enzim Aspartate aminotransferase dan Alanin aminotransferase p<0,05%. Enzim Alanin aminotransferase sebagian besar terikat pada sitoplasma, sedangkan Aspartate aminotransferase terdapat dalam semua jaringan tubuh, terutama hati dan dalam jumlah lebih kecil di ginjal dan otot rangka, sebagian besar enzim Aspartate aminotransferase  terikat pada organel sel, dan hanya sedikit terdapat di sitoplasma. Enzim Aspartate aminotransferase dan Alanin aminotransferase meningkat bila terjadi kerusakan sel hati. Biasanya peningkatan Alanin aminotransferase lebih tinggi daripada Aspartate aminotransferase pada kerusakan hati yang akut, mengingat Alanin aminotransferase merupakan enzim yang hanya terdapat pada sitoplasma sel hati. Peningkatan aktivitas enzim transaminase merupakan petunjuk yang paling peka dari nekrosis sel-sel hati, karena peningkatannya terjadi paling awal dan paling akhir kembali ke kondisi normal dibandingkan tes yang lain.
Vermisidal dan Ovisidal Ekstrak Metanol Biji Pepaya Muda Terhadap Ascaridia galli Secara In-Vitro
Authors: Sonda Kristina Sartika , Samsuri Samsuri , Oka Ida Bagus Made
Published: October 2019

Di dalam biji pepaya muda terkandung beberapa zat aktif seperti glikosida, alkaloid karpain, benzyl-isothiocianate (BITC) dan enzim papain yang telah terbukti dapat membunuh cacing dan menghambat daya berembrio telur cacing Ascaridia galli. Tujuan penelitian ini untuk mengetahui vermisidal dan ovisidal ekstrak methanol biji pepaya muda terhadap cacing Ascaridia galli.  Rancangan Acak Lengkap (RAL) digunakan dalam penelitian ini yakni  untuk uji vermisidal terdiri dari 6 perlakuan (P0, P1, P2, P3, P4, P5) dan 5 ulangan, sedangkan untuk uji ovisidal dibagi menjadi dua uji, yaitu kontak langsung dan kontak tidak langsung. Perlakuan yang diberikan; Kontrol Negatif (P0) dengan larutan NaCl Fisiologis, Kontrol Positif (P1) dengan larutan Albendazole (Benzamidazole 0,15 ml/kg berat badan), perlakuan II (P2), ekstrak biji pepaya muda konsentrasi 0,07 %, perlakuan III (P3), ekstrak biji pepaya muda konsentrasi 0,14 %, perlakuan IV (P4), ekstrak biji pepaya muda konsentrasi 0,21 %, perlakuan V (P5), ekstrak biji pepaya muda 0,28 %. Untuk uji vermisidal data dianalisis dengan Analisis Probit untuk mengetahui LC100 (Lethal Concentration) dan LT100 (Lethal Time) dari ekstrak biji pepaya muda sedangkan untuk uji ovisidal data dianalisis dengan Sidik Ragam Hasil penelitian vermisidal didapatkan LC100 ekstrak biji pepaya muda adalah 0,371 % dan LT100 34,614 jam. Untuk uji ovisidal kontak langsung dan kontak tidak langsung didapatkan bahwa ekstrak biji pepaya muda berpengaruh sangat nyata (P<0,05) terhadap daya berembrio telur cacing Ascaridia galli. Dari hasil penelitian ini dapat disimpulkan bahwa ekstrak biji pepaya muda efektif sebagai vermisidal dan ovisidal kontak langsung terhadap cacing Ascaridia galli secara in-vitro.
Gérer la diversité animale dans les systèmes d’élevage : laquelle, comment et pour quels bénéfices ?
Authors: MAGNE Marie-Angélina , NOZIÈRES-PETIT Marie-Odile , COURNUT Sylvie , OLLION Émilie , PUILLET Laurence , RENAUDEAU David , FORTUN-LAMOTHE Laurence
Published: October 2019

La biodiversité, et en particulier la diversité animale que l’éleveur choisit d’élever, est présentée comme un levier prometteur pour la transition agroécologique et la résilience des systèmes d’élevage. Or, les travaux traitant de cette question sont peu nombreux, récents et épars. Cet article vise à développer un cadre conceptuel pour analyser de manière intégrée la diversité animale et ses modalités de gestion à l’échelle des systèmes d’élevage et à proposer des pistes de recherche pour y contribuer. Ce cadre est structuré en quatre composantes : i) les formes que recouvre la diversité animale, ii) les niveaux organisationnel et temporel auxquels elle se construit et s’exprime, iii) ses modes de gestion et iv) les bénéfices retirés par l’éleveur. Quatre études de recherche contrastées en termes de diversité animale analysée ont été revisitées au travers du cadre conceptuel proposé. Leur relecture et leur analyse transversale montrent l’intérêt d’articuler les quatre composantes du cadre pour raisonner de manière intégrée la gestion de la diversité animale en élevage afin d’en tirer parti sur le long terme. Elles permettent aussi d’identifier trois fronts de recherche à investiguer conjointement : affiner la caractérisation de la diversité animale en élevage, mieux caractériser ses modes de gestion y compris ses déterminants et approfondir l’évaluation des différents bénéfices retirés de sa gestion. Des pistes d’utilisation du cadre en recherche, en enseignement et dans conseil en élevage sont enfin proposées.
Four‑Stage Evolution of Diabetes or Whole Body Insulin Resistance (WBIR): Debunking of the Lipid‑Induced Insulin Resistance (LIIR) and Proposing of the Glycation‑Induced Insulin Resistance (GIIR)
Authors: Lee Song Jae , Shin Sang Won
Published: October 2019

Even though it has long been known that diabetes develops in distinctive stages over a long span of time, no comprehensive diabetes development model has been developed yet. Insulin resistance (IR) plays a central role in development of diabetes. A widespread belief regarding IR is that it is a global parameter affecting the whole body simultaneously by impairing merely glucose uptake in tissues. However, the analysis by a new methodology that we have named integrated approach suggests that IR not merely impairs glucose uptake in tissues but also produces tissue-specific metabolic disruptions varying widely from tissue to tissue, and that IR would not necessarily develop simultaneously over the whole body but instead develop first preferentially in the muscle tissue with a relatively low cell turnover and then progress in sequence to the subcutaneous adipose tissue to the visceral adipose tissue to the liver with higher cell turnovers. This is the most important rationale for subdividing IR into four distinct tissue-specific IRs: muscle insulin resistance (MIR), subcutaneous adipose insulin resistance (s-AIR), visceral adipose insulin resistance (v-AIR), and hepatic insulin resistance (HIR). Sequential development of tissue-specific IRs, in the order of MIR, s-AIR, v-AIR, and HIR, producing tissue-specific metabolic disruptions, is nothing but the whole body insulin resistance (WBIR) evolving in four distinctively insulin-resistant stages. Four-stage evolution from rapid weight gain to visceral obesity to rapid weight loss to full-blown diabetic state not only complies well with the natural development history of diabetes, but also resolves most of controversies on diabetes or obesity. Development of the four-stage WBIR evolution model, which also refutes the entrenched notion of the lipid-induced insulin resistance (LIIR) but instead supports the glycation-induced insulin resistance (GIIR) proposed in this study, may possibly be considered a breakthrough in study of diabetes as well as obesity.
Pembuatan Biodiesel Dari Minyak Biji Alpukat (Persea americana) Melalui Proses Transesterifikasi Langsung
Authors: Shafira Shafira Dwita Purnama Putri , Zulmanelis Zulmanelis , Darsef Darsef
Published: October 2019

Abstrak

Penelitian ini bertujuan untuk menentukan kondisi optimum pembuatan biodiesel dari minyak biji alpukat melalui proses transesterifikasi langsung. Variasi yang digunakan pada penelitian ini adalah variasi waktu reaksi 8, 12, 16 dan 20 jam serta variasi perbandingan campuran heksana-metanol 1:2 dan 1:5. Katalis yang digunakan adalah H2SO4 sebesar 20% berat yang diimpregnasi ke dalam serbuk biji alpukat. Hasil penelitian menunjukkan kondisi optimum pembuatan biodiesel dari biji alpukat adalah pada waktu reaksi 16 jam dengan perbandingan campuran heksana-metanol 1:5. Volume akhir biodiesel yang didapatkan sebesar 1,6 mL dengan densitas sebesar 910,7 kg m-3, viskositas kinematik sebesar 3,3051 cSt dan bilangan asam 1,9418 mg KOH g-1 lemak. Berdasarkan analisis GC-MS produk biodiesel dari kondisi optimum yang berhasil terkonversi adalah metil palmitat

Kata kunci: biji alpukat, biodiesel, metil ester, transesterifikasi langsung

Abstract

The aim of this study was to determine the optimum conditions of making biodiesel from avocado seed oil through a direct transesterification process. The variations used in this study were reaction time of 8, 12, 16 and 20 hours and hexane-methanol mixture of 1:2 and 1:5. The catalyst used was H2SO4 of 20% (wt) that has been impregnated into avocado seed powder. The results showed that the optimum conditions for making biodiesel from avocado seeds were at the reaction time of 16 hours with a hexane-methanol mixture ratio of 1:5. The final volume of biodiesel was 1.6 mL with a density of 910.7 kg m-3, kinematic viscosity of 3.3051 cSt and acid number 1.9418 mg KOH g_1. Based on GC-MS analysis of biodiesel products from the optimum conditions the resulted of fatty acid methyl ester is methyl palmitate.

Keywords: avocado seeds, biodiesel, direct transesterification, methyl ester.
The Characteristics of Responses to Smart City Device Usage, Maqasid Shariah (The Objective of Shariah) Perspective: The Case of Kota Depok, West Java, Indonesia
Authors: Siswantoro Dodik
Published: October 2019

The research aims to analyze the characteristics of smart city device usage from maqasid shariah perspective. The smart city device was developed to support users to fulfill their needs which actually relates to maqasid shariah. Therefore, the higher rate of smart city device usage will increase the quality of life. This includes such factors that make people use this device. This research employs the quantitative method based on the questionnaires distributed to the people of Kota Depok, Indonesia. This device is supposed to increase the activity level of smart city. In fact, only few people use smart city device for their needs and purposes. The benefit of the device is a significant factor to use the smart city device. In addition, not all maqasid shariah aspects covered in the smart city device of Kota Depok.
Arthroscopic Microfracture for Osteochondral Lesions of the Talus
Authors: Yang Hong-Yeol , Lee Keun-Bae
Published: October 2019

Background:

Arthroscopic microfracture is considered the primary treatment strategy for osteochondral lesions of the talus and has been shown to provide successful outcomes. However, deterioration of clinical outcomes and fibrocartilage infill over time is now a recognized concern. The purpose of the present study was to evaluate the outcomes related to cartilage repair tissue after microfracture with use of second-look arthroscopy and magnetic resonance imaging (MRI) and to compare these findings with functional outcomes.

Methods:

Twenty-five patients underwent second-look arthroscopy and MRI at a mean of 3.6 years (range, 2.2 to 8.1 years) after microfracture. Second-look arthroscopic findings were assessed according to the system of the International Cartilage Repair Society (ICRS). MRI was evaluated postoperatively with use of the magnetic resonance observation of cartilage repair tissue (MOCART) score. Clinical outcomes were determined with use of the Foot and Ankle Outcome Score (FAOS), the American Orthopaedic Foot & Ankle Society (AOFAS) ankle-hindfoot scale, and the Short Form-36 (SF-36) score.

Results:

On second-look arthroscopy, 9 ankles (36%) were still abnormal according to the ICRS overall repair grades. The average postoperative MOCART score was 67.8 (range, 30 to 95), with good association with functional outcome. In addition, 6 patients (24%) had a mismatch between the MRI and second-look arthroscopic findings. Significant improvements were observed in all functional outcome categories between the preoperative and latest follow-up evaluations (p < 0.001). The mean FAOS scores for ICRS repair grades I and II (n = 16) and grades III and IV (n = 9) were 86.8 and 75.6, respectively. There was a significant correlation between FAOS scores and ICRS grades (p = 0.004).

Conclusions:

Second-look arthroscopic results revealed that 36% of lesions were incompletely healed and had inferior quality of repair tissue compared with that of native cartilage at a mean of 3.6 years, although arthroscopic microfracture provided functional improvements. Magnetic resonance analysis demonstrated some limitations in comparison with arthroscopy for the evaluation of cartilage repair. Therefore, second-look arthroscopy has an important role in accurately assessing the status of the cartilage repair tissue beyond the use of the MOCART score and functional outcomes.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.