bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPACT OF ADVANCED HEMODYNAMIC MONITORING ON MYOCARDIAL REVASCULARIZATION SURGERY IN HIGH-RISK PATIENTS
Authors: Djosci Coêlho de Sá Henrique , Costa de Mello Farah Vinicius , Fernandes Alevato Lucca , Zanetti Pinheiro Thiago , Víctor Elias Sobrinho Paulo , Sérgio Martins Neto José , Andre Ramalho Rangel Lima Paulo , Bandeira de Mello Sanches de Almeida Eduardo , Hugo Mendes da Cunha Vitor , Vitor Gullo de Oliveira Ribeiro Antônio , Tibério Campos Calegário Luiza , De Oliveira Figueiredo Bruno
Published: October 2024

Coronary artery bypass grafting is a critical procedure for patients with advanced coronary disease, especially those classified as high risk due to comorbidities such as heart failure, hypertension and diabetes. Advanced hemodynamic monitoring has proved essential in this context, allowing continuous and accurate surveillance of cardiac and vascular parameters, which can reduce intra- and post-operative complications. This abstract aims to assess the impact of advanced hemodynamic monitoring during coronary artery bypass graft surgery in high-risk patients. The aim is to explore the advantages of this type of monitoring, the technologies used and the benefits in terms of clinical outcomes and reduction of complications. This is a literature review with a qualitative approach, carried out in the PubMed, SciELO, LILACS, BVS and Google Scholar databases. In order to optimize the search, descriptors such as Hemodynamic Monitoring, Cardiac Surgery, High Risk Patients and Fluid Management were used. For time delimitation, the research considered publications between the years 2019 and 2022, a period that reflects the latest advances in hemodynamic monitoring technologies in high-risk cardiac surgeries. Advanced hemodynamic monitoring includes the use of devices such as the pulmonary artery catheter and non-invasive bioimpedance systems, which provide real-time data on cardiac output, blood pressure, oxygen saturation and systemic vascular resistance. In high-risk patients, these devices allow for precise adjustments in the administration of fluids and vasoactive drugs, promoting better hemodynamic stability. Studies indicate that this approach reduces the incidence of serious complications, such as cardiogenic shock and arrhythmias, optimizing post-operative recovery. Therefore, advanced hemodynamic monitoring is a crucial tool in CABG surgeries, especially for high-risk patients. Its implementation improves intraoperative management, reducing the risk of complications and promoting better clinical outcomes. Therefore, its use should be considered an integral part of strategies for complex cardiac surgeries.
Türk Savunma Sanayiinde Dijital Olgunluk Seviyelerinin Karşılaştırılması
Authors: Demirel Bülent Eren , Tınmaz Gülbahar , Güven Emel , Eren Tamer
Published: October 2024

Amaç: Günümüz rekabetçi ekonomisinde firmaların ayakta kalabilmeleri için dijital olgunluk seviyelerinin değerlendirilmesi önemlidir. Bu çalışmada, Türk savunma sanayii kapsamındaki dört firmanın dijital olgunluk düzeyleri incelenmiştir. Değerlendirme, firmaların eksikliklerini belirleyip çözümler sunarak rekabet avantajı, sürdürülebilirlik ve verimlilik sağlamayı hedeflemektedir.
Yöntem: Problemde kullanılan kriterlerin ağırlıklandırılmasında Analitik Hiyerarşi Süreci (AHP) yöntemi kullanılmıştır. Ardından alternatif seçimlerinde ise çok kriterli karar verme yöntemlerinden Technique for Order Preference By Similarity To Ideal Solution (TOPSIS) ve Preference Ranking Organization Method for Enrichment Evaluation (PROMETHEE) yöntemleri tercih edilmiştir.
Bulgular: Dijital olgunluk, akıllı üretim sistemleriyle verimliliği artırma kapasitesi olarak tanımlanmıştır. AHP ile ağırlıklandırılan kriterler arasında “Endüstri 4.0 Teknolojileri Kullanma Süreçleri” en öncelikli kriter olarak belirlenmiştir. TOPSIS ve PROMETHEE yöntemleriyle yapılan sıralamalarda 1. Firma en üst sırada yer almıştır. Çalışma, firmaların dijital dönüşüm süreçlerindeki güçlü ve zayıf yönlerini ortaya koymuştur. Gelecek araştırmalar için sektörel analizler ve yeni yöntemler önerilmektedir.
Özgünlük: Bu çalışma, AHP, TOPSIS ve PROMETHEE yöntemlerini kullanarak Türk savunma sanayiindeki firmaların dijital olgunluk seviyelerini analiz eden özgün bir metodolojik yaklaşım sunmaktadır. Analiz, sektördeki firmaların dijital dönüşüm stratejilerini optimize etmelerine katkı sağlamaktadır.
Through the Chat Window and Into the Real World: Preparing for AI Agents
Authors: Toner Helen , Bansemer John , Crichton Kyle , Burtell Matthew , Woodside Thomas , Lior Anat , Lohn Andrew , Acharya Ashwin , Cibralic Beba , Painter Chris , O’Keefe Cullen , Gabriel Iason , Fisher Kathleen , Ramakrishnan Ketan , Jackson Krystal , Kolt Noam , Crootof Rebecca , Chatterjee Samrat
Published: October 2024

Computer scientists have long sought to build systems that can actively and autonomously carry out complicated goals in the real world—commonly referred to as artificial intelligence "agents." Recently, significant progress in large language models has fueled new optimism about the prospect of building sophisticated AI agents. This CSET-led workshop report synthesizes findings from a May 2024 workshop on this topic, including what constitutes an AI agent, how the technology is improving, what risks agents exacerbate, and intervention points that could help.
The Effect of Financial Rewards on Employee Commitment at Kinondoni Municipal Council, Dar es Salaam, Tanzania
Authors: Millinga Oresta , Barongo Felician
Published: October 2024

This study was carried out to find out the effects of reward system on employees commitment in public sector in Tanzania based on Kinondoni Municipal Council. The specific objective of the study were to determine effect of financial rewards on employees’ working efforts at Kinondoni Municipal Council. The research drew from expectancy theory and Herzberg’s Two Factor theory to guide its direction, while a conceptual framework was constructed to illustrate the connections between the variables under investigation. Employing an explanatory research design, the study opted for a combination of simple random and purposive sampling methods to recruit 118 participants from the target population of 2500 staff. Both questionnaire and interview were used to gather data from the respondents. Data that were gathered through questionnaire were analysed using descriptive and regression analysis while data that were collected through interview were analysed using content analysis. It was revealed that organisation overtime pay offered by staff adequately reflects the extra effort put into work while employees have a pension plan makes them feel more secure about their future, which allows employees to focus better on their work.  The study concludes that reward system, fringe benefits and recognition schemes have significant effect on employees’ working efforts at Kinondoni Municipal Council.  It was recommended that there is a need to ensure that employees receive competitive salaries which attract and retain top talent at Kinondoni Municipal Council. This policy implication can lead to increased job satisfaction, motivation, and commitment among employees.
CONTRIBUTOS DA PSICANÁLISE À UNIVERSIDADE: ASPECTOS PSICODINÂMICOS DAS COMPETÊNCIAS TRANSVERSAIS NO ENSINO SUPERIOR
Authors: Xavier Fabiano Pedro , Xavier Silvia Carla da Silva , Ribeiro Iraquitan José Leite
Published: October 2024

Há, no ensino superior, assim como na educação de modo geral, um mal-estar, refletido na inquietação, frustração ou desânimo por parte de educadores e educandos, que tendem a dirigir a culpa, de tal situação, um para o outro. A proposta deste trabalho atentou para o fenômeno psicodinâmico das competências transversais em Instituição de Ensino Superior – IES. Este artigo tem como objetivo tecer interlocução entre psicanálise e universidade ao discutir a implementação de elementos da teoria psicanalítica como aportes teóricos que possibilitam apropriação de competências transversais. Para tanto, mostra-se como vários desdobramentos práticos daqueles possíveis suportes que já são de conhecimento da pedagogia, mais especificamente de Paulo Freire. Com a referência a conceitos de Freud e Lacan, como os de “desejo”, “sujeito-suposto-saber” e, principalmente, de “transferência”. Focando, assim, nas questões intrassubjetivas, realiza-se uma leitura sobre as questões transferenciais e didáticas. Para sustentar a presente discussão, propõe-se uma incursão à psicanálise. Dessa forma, o indivíduo destaca-se pela sua capacidade de transpor os conhecimentos adquiridos em um determinado contexto de formação profissional para novas realidades, quase sempre imprevisíveis. Essa capacidade de lidar com estas novas situações comuns hoje no mundo do trabalho pode ser definida como competência na educação contemporânea.
ATUAÇÃO DO ENFERMEIRO FRENTE AO TRANSTORNO DE ANSIEDADE GENERALIZADA
Authors: Bernardo Helab Geika Matias , Santos Francis Ismaiaria Rodrigues dos , Pereira Valeria Ferreira , Oliveira Geane Silva , Souza Anne Caroline de , Medeiros Renata Lívia Silva Fonseca Moreira de
Published: October 2024

Introdução: o Transtorno de Ansiedade Generalizada (TAG), caracteriza-se por uma ansiedade crônica, também, é acompanhado de sintomas, fisiológicos e psicológicos, especialmente por preocupações excessivas e frequentes, tornando-se de difícil controle. O profissional enfermeiro em saúde mental deverá desenvolver suas funções em relação aos cuidados iniciais em saúde mental, o mesmo deve ficar atento aos sinais e sintomas dos indivíduos com transtorno mental ou em sofrimento psíquico, é importante a atuação no tratamento dos quadros psiquiátricos estabilizados, sempre na busca de prevenção e promoção da saúde mental. objetivo: identificar na literatura a atuação do enfermeiro frente ao transtorno de ansiedade generalizada. Metodologia: o presente estudo trata-se de uma revisão integrativa da literatura, baseada na seguinte questão norteadora: qual a atuação do enfermeiro frente ao transtorno de ansiedade generalizada? A coleta dos dados aconteceu entre os meses de julho e agosto do presente ano, através das bases de dados Scientific Electronic Library Online (SciELO) e Biblioteca Virtual em Saúde (BVS), fazendo uso dos descritores em ciências da saúde (Decs): atuação, enfermeiro e transtorno de ansiedade generalizada. Para os critérios de inclusão foram adotados: artigos publicados entre os anos de 2020 a 2024, artigos disponíveis em português, de forma gratuita, que abordaram a temática e que estavam disponíveis na íntegra, foram excluídos os artigos que estavam duplicados, ou seja, aqueles presentes em mais de uma base de dados, artigos em espanhol, monografias, artigos incompletos, dissertações e aqueles que fugiam da proposta do estudo. Os dados coletados foram analisados qualitativamente e confrontados com a literatura pertinente. Resultados e discussões: é importante ressaltar que o transtorno de ansiedade generalizada, acomete pessoas de todas as idades, sendo mais frequentes em adultos mais velhos por questões da rotina muito corrida. O enfermeiro é visto como referência para o usuário e para a equipe de enfermagem e está sempre presente nas atividades desenvolvidas em relação ao atendimento direto ao usuário e família. Conclusão: portanto, é de fundamental importância atuação do enfermeiro frente ao transtorno de ansiedade generalizada, desde que o profissional citado esteja apto a desenvolver seu trabalho com competência, humanização e ética, tornando-se assim sua prática importantíssima.
Modeling the formation of toma hills based on fluid dynamics with a modified Voellmy rheology
Authors: Hergarten Stefan
Published: October 2024

Abstract. Toma hills are perhaps the most enigmatic morphological feature found in rock avalanche deposits. While it has been proposed that toma hills might emerge from the fluid-like behavior of rock avalanches, there still seems to be no consistent explanation for their occurrence. This paper presents numerical results based on a modified version of the Voellmy rheology, which was recently developed to explain the long runout of rock avalanches. In contrast to the widely used original version, the modified Voellmy rheology defines distinct regimes of Coulomb friction at low velocities and velocity-dependent friction at high velocities. When movement slows down, returning to Coulomb friction may cause a sudden increase in friction. Material accumulates in the region upstream of the point where this happens. In turn, high velocities may persist for some time in the downstream and lateral ranges, ultimately resulting in a thin deposit layer. In combination, both processes generate more or less isolated hills with shapes and sizes similar to those of toma hills found in real rock avalanche deposits. Thus, the modified Voellmy rheology suggests a simple mechanism for the formation of toma hills.
A Novel Nonlinear Stochastic-Resonance-Enhanced Acceleration Data Processing Approach
Authors: Gao Xuyu , He Di , Chen Xin , Xiang Yan , Zou Danping , Pei Ling
Published: October 2024

Abstract. Smartphones are indispensable tools in modern social life, and they can be used for online shopping, electronic payment, gaming, and navigation. In particular, low-cost inertial measurement unit (IMU) sensors are widely integrated into smartphones, so pedestrian dead reckoning (PDR) positioning techniques based on smartphone IMU sensors have been applied and developed. PDR positioning techniques require acceleration data for step detection, step length estimation, and step heading estimation. However, due to the cost limitations of the built-in IMU sensor in smartphones, acceleration data contains measurement noise and interference, resulting in poor consistency in acceleration peak detection and the generation of false peaks, which is not conducive to step detection and accurate step length estimation. Therefore, this paper proposes a stochastic resonance (SR) enhancement method for smartphone IMU acceleration data. The SR-enhanced acceleration data has better peak consistency and is conducive to step detection. Finally, the algorithm is evaluated using actual measurement data collected from a smartphone. The results show that the SR-enhanced acceleration data has excellent peak consistency and higher step detection accuracy.
“Breast-Is-Best” and Care in Fukazawa Ushio’s Chibusa no kuni de
Authors: Guarini Letizia
Published: October 2024

The “breast-is-best” ideology (bonyū shinwa), which is still firmly rooted in Japanese consciousness, can cause women stress and pain, becoming a source of anxiety and even depression. When used in fiction, we can read it as a topos that highlights the great pressure experienced by mothers as primary caregivers in contemporary Japanese society.In this paper, I analyze the representation of breastfeeding in relation to the concept of care in the novel Chibusa no kuni de (In the Country of Breasts, 2020) by Fukazawa Ushio. I argue that Fukazawa’s novel tackles the issue of “breast-is-best” discourse on several levels. On the one hand, this novel describes the discomfort that both the lack and overproduction of breastmilk can cause in women, and also depicts women who lack the so-called “maternal instinct.” On the other hand, the novel also questions the traditional view of care as something that should be performed at the individual level in the intimate sphere. My analysis of Fukazawa’s work will highlight the link between breastfeeding, care, and power, while shedding light on the interdependence between caregivers and care-receivers.
Breastfeeding, Folklore, and Nature
Authors: Buriticá Alzate Juliana
Published: October 2024

This article focuses on depictions of breastfeeding that move beyond idealization and/or realistic depictions of breastfeeding, and do not necessarily elicit an empathic, personal connection with the reader, but rather, I argue that it is via their engagement with Japanese folklore and nature, that they create the necessary distance to critically explore the question of breastfeeding within a feminist framework. I analyze the fantastical treatment of breastfeeding through its fictional representation in two short stories: “Higanbana” (彼岸花 Spider Lilies, 2014; trans. 2014) by Oyamada Hiroko, and “Enoki no isshо̄” (エノキの一生 Enoki, 2019; trans. 2020) by Matsuda Aoko. One of the representative features of the writing of both Oyamada and Matsuda is how they bring together fantastic events within realistic settings, blending realism and science fiction, the human and the non-human, the ordinary and the extraordinary. In the selected stories, both authors play with traditional beliefs and popular stories passed by word of mouth as well as feature personification and imagery of plants, flowers, and trees. This literary quality—problematizing “nature” and folklore while blending fantasy and reality—can be read as a subversive strategy for potential feminist critique. Hence, I read their depiction of breastfeeding in terms of it being fantasy grounded in reality, focusing on unraveling affects of shame and disgust, often associated to breastfeeding, and moving towards a reproductive justice framework.
Playing with the Classics, Playing the Classics—The Cyborg Ninja Genji in the Video Game Overwatch
Authors: Citko-DuPlantis Małgorzata Karolina
Published: October 2024

Tackling fundamental questions crucial for content creation in video game development, the article analyzes the cyborg ninja Genji character in an American video game Overwatch. It argues that Overwatch, while falling into global trends of Neomedievalism and techno-Orientalism, made Genji more famous and cooler (in the sense of the “Cool Japan” strategy) as a character and hero than ever before. It also emphasizes that since it is through Overwatch that most students currently access the term “Genji” online, the video game claimed the right to control the future of certain elements of premodern Japan’s cultural heritage.
ANALYSIS OF INHERITANCE AND HERITABILITY OF ECONOMICALLY VALUABLE TRAITS IN HYBRID BARLEY POPULATIONS
Authors:   Kazakh Research Institute of Rice Growing named after Ibrai Zhakhaev, Kyzylorda city, Kazakhstan, Tokhetova L.A. , Shermagambetov K. ,   Kazakh Research Institute of Rice Growing named after Ibrai Zhakhaev, Kyzylorda city, Kazakhstan, Baimbetova G.Z. ,   Kazakh Research Institute of Rice Growing named after Ibrai Zhakhaev, Kyzylorda city, Kazakhstan, Zhalbyrov A. E. ,   Kazakh Research Institute of Rice Growing named after Ibrai Zhakhaev, Kyzylorda city, Kazakhstan, Nurgaliyev N.Sh. ,   Korkyt Ata Kyzylorda University, Kyzylorda city, Republic of Kazakhstan, Sultan N.Zh. ,   Korkyt Ata Kyzylorda University, Kyzylorda city, Republic of Kazakhstan
Published: October 2024

The article presents the results of studying the nature of inheritance, heritability and variability of quantitative traits in 36 hybrid populations in conditions of saline soils of rice systems of the Kazakhstan Aral Sea region. Since variability and inheritance depend on the genotype and environmental conditions, the most valuable is the information obtained in a specific agroclimatic zone for which new varieties are created. It was established that the prevalence of additive gene interactions in the control of the studied traits in the conditions of the Aral Sea region indicates the possibility of effective selection already in the F2 generation, and in more favorable years, due to the high determination of these traits by dominant genes, it is necessary to differentiate hybrid populations, starting from the first generation and further selection to be carried out in several cycles until homozygosity of loci carrying dominant genes is achieved. The most accessible features for selection in early generations are: plant height, ear length, number of grains in an ear, the variability of which is caused by the action of additive genes, for which it is necessary to carry out targeted selection work to increase the productivity of barley in this region. Hybrid populations with high values of the heritability coefficient for certain features and for their complex have been identified: Bi-16 x Saule (by five features); Syr Aruy x Donetskiy 8, Syr Aruy x Odesskiy 100, Bi-17 x Saule (by four), in which it is necessary to select highly productive forms adapted to stressful environmental conditions
BIOECOLOGICAL SUBSTANTIATION OF THE EFFECTIVENESS OF ENTOMOPHAGES OF PEA PESTS (PISUM SATIVUM L.) IN THE AKMOLA REGION
Authors:   Taraz Regional University named after M.H.Dulati, Taraz city, Kazakhstan, Mombaeva B.K. , Tumenbayeva N.T. ,   Kazakh Agrotechnical Research University named after S.Seifullin, Astana city, Kazakhstan, Kaliyeva L.T. ,   Kazakhstan Agrarian and Technical Universitynamed after Zhangir Khan, Uralsk city, Kazakhstan, Ualiyevа A.B. ,   Shakarim Semey University, Semey city, Kazakhstan, Dosmaganbetova А.О. ,   Shakarim Semey University, Semey city, Kazakhstan
Published: October 2024

Ақмола облысы жағдайында, бұршақ дақылының зиянкестері бұршақ бітесі мен түйнекті бізтұмсықтың жаппай көп кездескен энтомофагтары анықталды, олардың санының ауытқуы, экологиялық жағдайлардың энтомофагтарға әсер ету дәрежесіне байланысты биологиялық ерекшеліктері зерттелді, сонымен қатар энтомофагтардың тиімділігі негізделді. Зерттеу нәтижелері негізінде, зиянкес түйнекті бізтұмсықтардың санын басуда жыртқыш майда қоңыздардың ішінен энтомофагтардың басым, өте маңызды, тиімді топтары анықталды. Олар: Bembidion femoratum, V. quadrimaculatum, V. lampros, Microlestes minutulus. Ал, бұршақ бітесінің энтомофагтары қатарына бұршақ дақылының әртүрлі өсу кезеңдерінде кездесетін, экологиялық жағдайларға бейімделген, көп кездесетін (Syrphidae тұқымдасының түрлері: SyrphusribesiiL., S. CorollaeR., S. balteatusDeg., Sphaerophohasp.; Coccinellidae: Coccinella septempunctata L., С quinguepunctata L., Propylaea quatuordecinpunctata L., Hippodamia tredecimpunctata L, Adoniavariegata Goeze., C. trifasciataL., Chrysopidae: Chrysopacarnea Steph., Ch. semptempunctata). Сонымен қатар, фитофагтар мен энтомофагтардың маусымдық динамикасы мен биоэкологиясы зерттелді. Аймақтағы бұршақ дақылының бұршақ бітесі зиянкестерінің кокцинеллид (Coccinellidae) туысының үш түрі табылды, ал, түйнекті бізтұмсық зиянкестерінің 4 түрлі жыртқыш майда қоңыздары анықталды. Ақмола облысы, Шортанды ауданы жағдайында бұршақ дақылының зиянкестерінің энтомофагтарының тиімділігіне биоэкологиялық негіздеме берілді.
Göçün Eğitim Üzerindeki Etkilerinin Göçmen Veli Görüşlerine Göre Değerlendirilmesi
Authors: TAŞER Seyit
Published: October 2024

The aim of this study is to determine the problems experienced by immigrants in the field of education through interviews. Evaluating the views of immigrant students' parents on this issue, it was desired to get concrete results in the field. At the same time, taking into account the situations that developed due to the pandemic, questions were asked regarding access to distance education. In this study, the interview method was applied within the scope of qualitative research. Data were obtained by using semi-structured interview forms. The sample of the study consists of seven immigrant families living in Konya. The semi-structured interview form used in the study was developed by the researcher himself. When the findings are examined, it has been seen that the problems experienced by these immigrant families who have lived in Turkey for a certain period of time in relation to education do not make a significant difference from other individuals who are Turkish Citizens. This is not true for all children of parents, especially if there are problems with adaptation. Participants in the research stated that they learned Turkish by overcoming language-related problems in a short time in terms of communication. Immigrant parents stated that they are very satisfied with the education in Turkey. Key Words: İmmigration, Parents, Education, Matters
Ética nas pesquisas acadêmicas: refletindo com mestrandos e doutorandos sobre posicionamentos ativistas necessários
Authors: de Sousa Soares Ademilson , Suzane Gomes Mendes Débora , Vargas Consoli Rennó Giovanna , Henrique Calais Silva Guilherme , Barbosa Juliana , Mendes Costa Amaral Paula
Published: October 2024

Este trabalho surgiu no bojo das reflexões construídas com mestrandos e doutorandos participantes da disciplina “Ética na pesquisa: desafios e dilemas nas Ciências Humanas e na Educação”, ofertada no Programa de Pós-Graduação em Educação da Faculdade de Educação da Universidade Federal de Minas Gerais (UFMG). O texto decorre da necessidade de agir-se na realidade da pesquisa e da percepção de que a escrita acadêmica, seguida da publicação de resultados das investigações, é uma importante maneira de assumir um posicionamento ativista, conforme defendido por Stetsenko (2021). Após sustentar a necessidade de uma postura de compromisso ético adequado com os processos de pesquisa, apresentam-se reflexões necessárias ao combate a todas as formas de fraude, tais como plágios e autoplágios. Finalmente, argumenta-se que uma epistemologia da destinação deve orientar um posicionamento ético ativista e transformador nas Ciências Humanas e nas pesquisas em Educação.
Safety evaluation and effects of cascara pulp Gayo Arabica coffee cream as anti-photoaging in animal model
Authors: Lestari Wahyu , Hajar Sitti
Published: October 2024

Prolonged sunlight and ultraviolet (UV) exposure causes premature skin aging called photoaging and coffee-derived topical antioxidants may help to reduce this process. Since a significant amount of antioxidant-rich cascara pulp are wasted in coffee processing, this study aimed to evaluate the safety of cascara extract cream of Gayo Arabica coffee pulp (CECGACP) as anti-photoaging in male Wistar rats (Rattus norvegicus) by assessing the skin primary irritation index (PII), skin macroscopic changes and the level of tumor necrosis factor-alpha (TNF-α). Twenty-five rats were randomly divided into five different groups: negative control (base cream only), positive control containing L-ascorbic acid 3%, and three treatment groups treated with cream containing 5%, 7.5% and 10% of CECGACP. The CECGACP was extracted, formulated into cream as a topical treatment and applied on the backs of the rats two times a day, once before the UV exposure and four hours after the exposure. After four weeks, the skins were macroscopically examined, and the TNF-α levels were measured. The PII was assessed after applying the cream 24 hours before UX exposure. Our data suggested that CECGACP was considered safe because there were no erythema and edema formation on the skin of the rats with PII score of 0 (classified as no irritation or negligible). After UV exposure, all rats had visible wrinkles and erythema on the skin in particular in the first week. After administration of CECGACP, both wrinkles and erythema were decreased. The levels of TNF-α varied from 0.15±0.02 ng/mL in the negative control and CECGACP 7.5% rat groups to 0.19±0.03 in the positive control group; however, there was no significant difference among all the groups. Our study suggests that CECGACP is safe to use in Wistar rats and able to reduce the erythema and edema due to UV exposure. However, the application of CECGACP does not provide a significant reduction of TNF-α levels.
Relationship of left ventricular diastolic dysfunction with quality of life in heart failure patients with reduced ejection fraction (HFrEF)
Authors: Khaidirman Sophia K. , Hasan Harris , Andra Cut A. , Lubis Hilfan AP. , Dangana Amos , Haykal T. Bob
Published: October 2024

Heart failure is a complex clinical manifestation due to diastolic dysfunction and systolic dysfunction of the left ventricle (LV). Diastolic dysfunction of the LV plays an important role in worsening the quality of life (QoL) in heart failure patients. The aim of this study was to assess the relationship between the severity or grade of LV diastolic dysfunction and QoL in heart failure with reduced ejection fraction (HFrEF) patients. A retrospective cohort study was conducted at the Cardiac Center of H. Adam Malik Hospital, Medan, Indonesia, from January 2022 to December 2022. This study included inpatients and outpatients aged above 18 years who were diagnosed with HFrEF, identified by echocardiography with an ejection fraction of ≤40%. Echocardiography was performed to evaluate left ventricular diastolic dysfunction, and QoL was assessed using the Minnesota Living with Heart Failure Questionnaire (MLHFQ) 6–12 months after the severity of LV diastolic dysfunction was confirmed. The MLHFQ was classified into good and poor QoL. The severity of LV diastolic function was measured using the E/A ratio, mean E/e' ratio, tricuspid regurgitation velocity (TR Vmax), and left atrial volume index (LAVI), and was classified into grades I, II, and III. The relationships between the severity of diastolic dysfunction and other factors with QoL were measured using Chi-squared, Fisher's exact test, or Mann-Whitney test, as appropriate. A total of 96 patients were included in the study, of which 56 (58.3%) patients had grade I, 12 (12.5%) had grade II, and 28 (29.2%) patients had grade III of LV diastolic dysfunction. There were 77 (80.2%) and 19 (19.8%) patients with good and poor QoL, respectively. This study revealed a significant relationship between the severity of LV diastolic dysfunction and QoL in HFrEF patients with p=0.040. In conclusion, the degree of LV diastolic dysfunction is related to the QoL of HFrEF patients and therefore better comprehensive management strategies should be considered in HFrEF cases to address the impact of LV diastolic dysfunction on QoL.
Black garlic exhibited hepatoprotective effect against monosodium glutamate-induced hepatotoxicity in animal model
Authors: Maulina Nora , Zachreini Indra , Gholib Gholib , Suwandi Abdulhadi , Akmal Muslim
Published: October 2024

Monosodium glutamate (MSG) is commonly used as a flavor-enhancing agent in foods, and studies have demonstrated its toxic effects in animal models. Black garlic is known for its antioxidant and anti-inflammatory properties; however, there is a lack of studies on the potential hepatoprotective effect of black garlic ethanol extract (BGE) against MSG-induced hepatotoxicity in rats. The aim of this study was to investigate the hepatoprotective effects of ethanol extract of black garlic against MSG-induced liver damage in animal model. Twenty-five male Wistar rats were randomly assigned to five groups (n=5): negative control, MSG only, and MSG with three different doses of BGE. The MSG only and MSG with BGE groups were orally administered with 8 mg/kg MSG daily. After MSG treatment, the MSG with BGE groups received BGE orally at daily doses of 200, 400, or 600 mg/kg body weight for 16 consecutive days. Subsequently, the levels of serum liver enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), interferon-gamma (IFN-γ), and cyclooxygenase-2 (COX-2) were measured. Our data indicated that the group treated with 200 mg/kg BGE had significant lower levels of AST and ALT significantly compared to the MSG-only group. The MSG-treated group had higher levels of the inflammatory markers COX-2 and IFN-γ, which were lowered by administration of 200 mg/kg BGE. In contrast, higher doses of BGE led to greater levels of COX-2 and IFN-γ compared to those in the MSG-only group. This study suggested that BGE might have hepatoprotective effects at low dose, potentially mitigating MSG-induced liver damage. However, the higher dose of black garlic extract did not alleviate inflammation, as shown by the higher levels of COX-2 and IFN-γ.
Factors associated with awareness of and undergoing Pap smear tests among Jordanian women
Authors: Annab Abeer , Lataifeh Lujain , Lataifeh Isam , Al-Rabadi Diala , Alkouri Osama , Khader Yousef S.
Published: October 2024

Several screening methods are used to detect cervical cancer, with Pap smear test is considered as one of the most reliable screening methods to diagnose cervical cancer. The aim of this study was to investigate the factors associated with awareness of undergoing Pap smear tests among Jordanian women. A cross-sectional study was conducted among 525 Jordanian women attending the outpatient maternity hospital consecutively from February to July 2023. Data encompassed demographic characteristics (age, occupation, and education), awareness of Pap smears, beliefs regarding their importance, sources of information, and the history of undergoing Pap smear tests were collected using a structured questionnaire. Of the total 525 Jordanian women, 87.6% were aware of Pap smears. The awareness varied significantly depending on age and education level. Women aged 41–50 (adjusted odds ratio (AOR): 6.0; 95%CI: 2.3–15.3) and with a university education (AOR: 2.6; 95%CI: 1.4–4.8) were associated with increased odds of being aware of Pap smears. Among the women who were aware of Pap smears, the majority (94.1%) expressed belief in the importance of undergoing Pap smear tests and 61.7% reported having undergone the procedure at least once in their lives. In the multivariate analysis, women aged 30–40 years (AOR: 1.7; 95%CI: 1.1–2.8), 41–50 years (AOR: 4.1; 95%CI: 2.3–7.3), and older than 50 years (AOR: 9.8; 95%CI: 4.2–23.0) had a higher likelihood of undergoing Pap smear tests than those of under 30 years old. Being a housewife (AOR: 1.7; 95%CI: 1.1–2.7) and those who believed in the importance of Pap smear testing (AOR: 2.6; 95%CI: 1.1–6.0) were also more likely to have a Pap smear test. Nearly half of the women who had undergone Pap smears reported doing so every 2–3 years, while 25.7% indicated annual screening. Importantly, the overwhelming majority (97.9%) preferred the procedure to be performed by a gynecologist. In conclusion, the majority of women were aware of Pap smears. Two-thirds of women reported having undergone the procedure at least once. Prevention programs targeting cervical cancer and Pap smear tests should be tailored to women with low education, younger than 30 years, and those employed to maximize screening uptake for cervical cancer.
Finding the new potential research on diabetic kidney disease and hemodialysis in healthcare insurance databases: A bibliometric analysis
Authors: Kresnowati Lily , Suhartono Suhartono , Shaluhiyah Zahroh , Widjanarko Bagoes
Published: October 2024

To the best of our knowledge, bibliometric analysis has not been performed for studies related to diabetic kidney disease (DKD) and hemodialysis using healthcare big data. Herein, the aim of this bibliometric analysis was to identify emerging research trends in DKD and hemodialysis within healthcare insurance databases by exploring authors, co-author networks, and countries to discover new potential research areas. A bibliometric study was conducted, utilizing data obtained from the Scopus database. Keywords such as diabetic kidney disease, hemodialysis, insurance or big data, and prediction were employed. Inclusion criteria were original articles and review articles written in English published between 2010 and 2022. VOSviewer and the Bibliometrix package in R were used for comprehensive bibliometric analysis. VOSviewer facilitated keyword co-occurrence analysis to identify clusters and visualize relationships among keywords, emphasizing distinct research themes, keyword density, and network visualization. Meanwhile, Bibliometrix allowed exploration of key metrics such as prolific authors and institutions, publication trends, co-authorship networks, citations, document types, emerging trends through keyword analysis, and network visualizations, including co-authorship and keyword co-occurrence. Results from both tools were integrated for a thorough analysis. The present study yielded 2,199 articles, which was reduced to 1,828 after removing duplicates and applying inclusion criteria. This bibliometric analysis found that machine learning and artificial intelligence are emerging yet remain relatively under-researched in the context of hemodialysis and DKD. The prominence of topics such as diabetic nephropathy, non-insulin treatments, and lifestyle modifications highlighted ongoing research priorities in DKD and hemodialysis. Taiwan's dominance in publications suggested robust research activity in this field, while international collaboration underscored global interest and the potential for diverse research perspectives. The need for similar research development in Indonesia, leveraging big data and machine learning, indicates opportunities for advancing the understanding and management of DKD and hemodialysis within the region.
Antioxidant and immunomodulatory activities of ethanol extracts from Syzygium cumini L. Skeels and Pogostemon cablin Benth
Authors: Faradilla Meutia , Fidrianny Irda , Iwo Maria I.
Published: October 2024

Syzygium cumini and Pogostemon cablin are mostly cultivated in tropical climates for culinary and perfumery purposes, yet their potential medicinal properties remain underreported. The aim of this study was to examine the antioxidant and immunomodulatory activities of ethanol extracts from S. cumini (EESC) and P. cablin (EEPC). Reflux extraction was carried out using 96% ethanol on the collected plant specimens to produce EESC and EEPC. Secondary metabolites of each extract were identified using gas chromatography-mass spectrometry (GC-MS). The extracts were measured for total phenol and flavonoid levels and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. The immunomodulatory activity test was carried out in vivo by assessing several parameters, including the phagocytic index via the carbon clearance method, organ indices, antibody titers, and delayed-type hypersensitivity (DTH) response, using sheep red blood cells (SRBC) as antigens. The extracts were also examined for their anti-inflammatory activity in acute and chronic inflammation models. In the DPPH antioxidant test, EESC and EEPC had IC50 values of 12.33 µg/mL and 182.17 µg/mL, respectively. Both extracts showed immunosuppressant activity, marked by a phagocytic index of <1. EESC yielded lower organ indices for the liver (p=0.025 at 200 mg/kg BW), spleen (p=0.028 at 100 mg/kg BW), and thymus (p=0.032 at 200 mg/kg BW) compared to the control group. For EEPC, lower organ indices were observed in the liver at 100 mg/kg BW (p=0.005) and 200 mg/kg BW (p=0.031). In the primary antibody titer and DTH tests, both EESC and EEPC showed immunosuppressant activity at 200 and 400 mg/kg BW (p<0.05). The extracts suppressed both the innate and adaptive immune systems. Both EEPC (p=0.004) and EESC at 100 mg/kg BW (p=0.03) significantly reduced serum TNF-α levels. In conclusion, EESC and EEPC have the potential as immunosuppressive and anti-inflammatory agents.
Potential of ant nest extract (Hydnophytum formicarum) for protection of testicular morphometry, epididymal functions, and sperm quality in male rats with alloxan-induced diabetes
Authors: Roslizawaty Roslizawaty , Abrar Mahdi , Khairan Khairan , Gholib Gholib , Siregar Tongku N. , Syafruddin Syafruddin , Sutriana Amalia , Azzahra Putri , Aini Hanipah
Published: October 2024

Medicinal herbs, such as the ant nest plant (Hydnophytum formicarum), are promising for the management of diabetes mellitus-associated infertility. The aim of this study was to evaluate the biological activity of the ant nest plant and its capacity to mitigate the adverse effects of alloxan-induced diabetes on testicular morphology, epididymal function, and sperm quality in male rats. The tuber of the ant nest plant was extracted using methanol and then subjected to phytochemical screenings. For the experiment, 20 male white rats (Rattus norvegicus), aged 3–4 months and weighing 150–200 g, were equally divided into four groups. The ant nest extract was administered orally using oral gavage over 14 days. The testes, epididymis, and sperm were collected for weighing, morphometric measurements, and quality evaluation. Qualitative testing of phytochemical compounds indicated the presence of flavonoids, tannins, steroids, terpenoids, and phenolic compounds in the plants. The results revealed the protective effects of ant nest extract against the adverse fertility effects induced by alloxan and a high-fat diet, as observed in testicular weight (p=0.045), epididymal weight (p=0.041), and sperm quality (p>0.05).
Професійна підготовка вчителя в умовах воєнного стану засобами педагогіки толерантності
Authors: Бирко Надія
Published: October 2024

У поданій статті висвітлено підсумки результатів ІІ концептуально-діагностичного етапу експерименту всеукраїнського рівня «Науково-методичне забезпечення реалізації авторської моделі «Школа толерантності», педагогічними колективами-учасниками якого є ліцей № 2  Хмельницької міської ради, гімназія № 6 Шепетівської міської ради Хмельницької області, Будинок дитячої творчості Нетішинської міської ради Хмельницької області. Метою дослідження визначено науково обґрунтувати та експериментально перевірити ефективність науково-методичного забезпечення реалізації авторської моделі «Школа толерантності».
За підсумками ІІ етапу експерименту учасниками-закладами освіти розроблено Концепцію з реалізації науково-методичного забезпечення авторської моделі «Школа толерантності», укомплектовано діагностичні методики та програми на визначення ефективності функціонування авторської моделі «Школа толерантності», психологами експериментальних закладів освіти підібрані, адаптовані та розроблені діагностичні комплекси з виявлення рівня толерантної особистості та толерантного середовища, керівниками закладів освіти забезпечено повний психолого-педагогічний супровід експерименту всеукраїнського рівня, учасниками експерименту розроблена модель  педагогічної системи «Школа толерантності», що враховує специфічні умови експериментальних закладів освіти, категорії учасників освітнього процесу та сучасні умови воєнного стану в Україні.
Особливості підготовки майбутніх учителів технологій в умовах реформування Нової української школи
Authors: Голіяд Ірина , Ребрина Марина
Published: October 2024

Стаття присвячена визначенню особливостей компетентнісної підготовки майбутніх учителів технологій у контексті Концепції Нової української школи. НУШ ставить нові виклики та завдання перед системою освіти і зокрема перед педагогічними закладами, які забезпечують підготовку майбутніх учителів технологій. Майбутні вчителі технологій  мають знати не лише  предмет, а й низку ключових компетенцій, які допоможуть їм підготувати майбутнє покоління до життя в динамічному світі. Особлива увага приділяється формуванню у майбутніх учителів готовності використовувати інноваційні технології, САПР та володіти графічною компетентністю.
Для підготовки майбутніх учителів технологій необхідні кваліфіковані викладачі, які мають глибокі графічні знання та досвід роботи в цій галузі. Педагоги мають опановувати сучасні методи та форми навчання, інноваційні  технології, навички використання ІКТ і САПР,  працювати з дітьми, налагоджувати співпрацю з практиками, роботодавцями, представниками громадськості.
У статті акцентується на перевагах кластерної моделі підготовки вчителів технологій, особливо щодо формування графічної грамотності. Автори порівнюють цей підхід з університетським навчанням, виділяючи ключові відмінності між ними.
Методологія впровадження акмеологічної концепції професійного розвитку майбутнього педагога з орієнтацією на духовне й моральне та інтелектуальне зростання особистості
Authors: Дубасенюк Олександра , Вознюк Олександр
Published: October 2024

У дослідженні проаналізовано особливості особистісно орієнтованого підходу до навчання різновікових груп суб’єктів освіти. Також окреслено шлях реалізації найбільш ефективної форми навчання (навчання інших/використання знань у конкретній діяльності) у контексті «піраміди навчання» як найбільш важливого узагальнення стратегій освітньої діяльності не тільки учнівської молоді, але й дорослих людей, що відображає градацію ефективності цих стратегій: від лекції як малопродуктивного засобу навчальної діяльності до найбільш ефективного засобу – навчання інших та практичне використання знань, виконання реальних дій, що реалізує ефект резонансу та феномен «дзеркальних нейронів».
Цей найбільш ефективний засіб освіти ілюструється через освітню систему видатного українського педагога О. Рівіна, відповідно до якої суб’єкти освітнього процесу засвоюють якісно і швидко лише те, що відразу після отримання/засвоєння нової інформації застосовують на практиці: «дізнався що-небудь – тут же розкажи, поясни іншому, застосуй на практиці, при цьому, якщо потрібно, то й неодноразово, іноді й багато разів». За таких умов учні застосовують набуті знання та розповідають/транслюють іншим ці знання доти, доки самі не засвоять їх, сформують відповідні вміння досконало.
Розглядаються такі напрями особистісно орієнтованого підходу у контексті психопедагогіки, як методики інтервальних повторень, супералгоритм (який реалізує феномен нейропластичності людського мозку), метод послідовного чергування циклів навчання.
Доведено, що сучасна система освіти різновікових груп суб’єктів освіти має інтегрувати як теоретико-практичні здобутки педагогічної науки (що втілені у «піраміді навчання»), так і здобутки психопедагогіки, яка становить певний синтез педагогіки та широкого кола наук про людину (одна з таких наук – нейропедагогіка). За таких умов як перспективу подальших розвідок вважаємо обґрунтування та створення цілісної системи освіти різновікових груп суб’єктів освіти, яка має поєднати колективно-партнерський та особистісно-індивідуальний аспекти освітньої діяльності.
Особистісне самовдосконалення як один з основних творчих чинників освіти впродовж життя
Authors: Орлова Ольга , Новіцька Інеса
Published: October 2024

У статті розглядається важливе питання сучасної освіти – удосконалення рівня професійної компетентності сучасного педагога через особистісне самовдосконалення. Розкрито підходи, які характеризують творчого, ініціативного педагога, який  може забезпечити розвиток та становлення особистості. Професійна компетентність сучасного педагогічного працівника формується за умови особистісного самовдосконалення. Розглянуто поняття особистісного самовдосконалення. Запропоновано аналіз методологічних принципів дослідження проблеми особистісного самовдосконалення в контексті розвитку професійної компетентності сучасного педагогічного працівника. Висвітлено проблему навчання впродовж життя як  самовдосконалення майбутнього педагога. У роботі показано результати аналізу теоретичних підходів щодо безперервного професійного самовдосконалення особистості як творчого чинника освіти впродовж життя.
Теоретичною основою дослідження автор обирає акмеологічний підхід, оскільки особистість за цим підходом зорієнтована на найвищі досягнення у професійному самовдосконаленні, а ядром в цьому процесі є ідея «самості». Автор розмежовує поняття «саморозвиток» та «самовдосконалення» особистості. Саморозвиток особистості розглядається як самотворче видове поняття, що входить до складу родового поняття «розвиток» і має в собі класове поняття «самовдосконалення». Представлена структура професійного самовдосконалення складається з цільового, змістового, інструментального, практичного і корекційного компонентів. Спираючись на праці дослідників у галузі освітніх наук, власні експериментальні дослідження, автор уточнює сутнісні характеристики та структурні компоненти особистісного самовдосконалення педагогів. Визначено, що важливою передумовою процесу самовдосконалення є ставлення самого фахівця до пропонованих вимог.
Автор доводить, що особистісні інноваційні зміни  насамперед залежать від педагога, його творчого потенціалу, підготовки до безперервної самоосвіти або навчання впродовж життя. Обґрунтовано, що при досконалій організації занять із самоосвіти постійно вдосконалюється професійна майстерність педагогів, їх творча діяльність, в результаті чого  формується авторитет педагогів серед учнів, батьків і колег.