bluuebunny/crossref_metadata_2025 huggingface dataset:
S2AI pelvic fixation is an important factor affecting sagittal spinal parameters in ADS patients in the short term after surgery: a retrospective study
Authors: Wang Xin-yu , Xi Jian-wei , Liu Lei , Han Meng , Liu Guang-pu , Zhang Jin , Ma Chao
Published: October 2023

Background
The incidence of degenerative scoliosis has increased significantly with the exacerbation of population aging, and there are many doubts about the methods and results of pelvic fixation for degenerative scoliosis. This study aimed to investigate the short-term changes in sagittal parameters of the spine after bilateral S2-ALAR-ILIAC (S2AI) screw fixation combined with posterior long-segment spinal fusion and internal fixation in ADS patients.
Methods
A total of 25 ADS patients who underwent bilateral S2AI internal fixation combined with posterior long-segment orthopedic surgery in Xuzhou Central Hospital from January 2018 to December 2022 were included in the retrospective analysis. The preoperative and postoperative Cobb angle, sagittal balance (SVA), pelvic incidence angle (PI), lumbar lordosis angle (LL), the difference between pelvic projection angle and lumbar lordosis angle (PI-LL), VAS score, ODI index, and JOA score were compared.
Results
All patients were followed up for at least 6 months. The mean Cobb, SVA, PI, LL, PI-LL were (42.67 ± 17.36)°,(70.44 ± 26.09) mm, (51.53 ± 7.67)°, (25.62 ± 13.27)°, (26.33 ± 10.44)°, (27.20 ± 9.56)°, respectively, the mean VAS score was (3.08 ± 0.28), the mean JOA score was (11.72 ± 1.10) and the mean ODI index was (63.08 ± 6.01)%. At 6 months postoperatively, mean scoliosis Cobb was (17.60 ± 7.19)°, mean SVA was (23.16 ± 12.39) mm, mean PI was (48.45 ± 5.42)°, mean LL was (38.01 ± 6.43)°, mean PI-LL was (10.45 ± 4.33)°, mean PT was (21.20 ± 6.32)°, mean VAS score was (8.64 ± 0.79) points, mean JOA score was (11.72 ± 1.10) points, and mean ODI index was (20.76 ± 2.74) %, with statistically significant differences (P < 0.05).
Conclusion
The clinical effect of bilateral S2AI technology combined with posterior long-segment fixation in treating ADS is significant and can effectively restore the sagittal sequence of the spine. However, careful correction of excessive lordosis should be made in the preoperative design to avoid PI-LL mismatch resulting in decreased postoperative quality of life.
Strategies to implement evidence-informed practice at organizations: A rapid systematic review
Authors: Clark Emily C , Burnett Trish , Blair Rebecca , Traynor Robyn L , Hagerman Leah , Dobbins Maureen
Published: October 2023

Background
Achievement of evidence-informed decision making (EIDM) requires the integration of evidence into all practice decisions by identifying and synthesizing evidence, then developing and executing plans to implement and evaluate changes to practice. Evidence-informed practice (EIP) involves implementing a specific practice or program with proven effectiveness. This rapid systematic review examines strategies for the implementation of EIDM and EIPs across organizations, mapping facilitators and barriers to the COM-B (capability, opportunity, motivation, behaviour) model for behaviour change.
Methods
A systematic search was conducted in multiple databases and by reviewing publications of key authors. Articles that describe interventions to shift teams, departments, or organizations to EIDM or EIP were eligible for inclusion. For each article, quality was assessed, and details of the intervention, setting, outcomes, facilitators and barriers were extracted from each included article. A convergent integrated approach was undertaken to analyze both quantitative and qualitative findings.
Results
Fifty-nine articles are included. Studies were conducted in primary care, public health, social services, occupational health, and palliative care settings. Strategies to implement EIDM and EIP included the establishment of Knowledge Broker-type roles, building the EIDM capacity of staff, and research or academic partnerships. Facilitators and barriers align with the COM-B model for behaviour change. Facilitators for capability include the development of staff knowledge and skill, establishing specialized roles, and knowledge sharing across the organization, though staff turnover and subsequent knowledge loss was a barrier to capability. For opportunity, facilitators include the development of processes or mechanisms to support new practices, forums for learning and skill development, and protected time, and barriers include competing priorities. Facilitators identified for motivation include supportive organizational culture, expectations for new practices to occur, recognition and positive reinforcement, and strong leadership support. Barriers include negative attitudes toward new practices, and lack of understanding and support from management.
Conclusion
This review provides a comprehensive, in-depth analysis of facilitators and barriers for the implementation of EIDM and EIP in public health and related organizations, mapped to the COM-B model for behaviour change. The facilitators and barriers described in the included studies establish key factors for realizing greater implementation success in the future.
Registration
PROSPERO CRD42022318994
General allometric equation for estimating aboveground biomass of Acacia-Commiphora forest, southern Ethiopia
Authors: Amanuel Wondimagegn , Tadesse Challa , Molla Moges , Getinet Desalegn , Mekonnen Zenebe
Published: October 2023

Most of the biomass equations were developed using sample trees collected mainly from pan-tropical and tropical regions that may over- or underestimate biomass. Site-specific models would improve the accuracy of the biomass estimates and enhance the country’s MRV activities. The aim of the study is to develop site & species-specific biomass estimation models and validate and evaluate the existing generic models developed for pan-tropical forest and newly developed allometric models. Total of 150 individual sample trees was harvested from each diameter class (proportionally) for the site-specific biomass model development. Data was analyzed using SAS procedures. All relevant statistical tests (normality, multicollinearity and heteroscedasticity) were performed. Data was transformed to logarithmic functions and multiple linear regression techniques were used to develop model to estimate aboveground biomass. The root mean square error (RMSE) was used for measuring model bias, precision and accuracy. The coefficient of determination (R2 & adj-R2), the Akaike Information Criterion (AIC) and the Schwarz Bayesian information Criterion (SBC) was employed to select most appropriate models. The results showed that a best fit-model for above-ground biomass of tree components (stem, branch and foliage) was developed.
AGBStem = exp {-1.8296 + 0.4814 Ln (ρD2H) + 0.1751 Ln (CW) + 0.4059 Ln (DSH30)}
AGBBranch = exp {-131.6 + 15.0013 Ln (ρD2H) + 13.176 Ln (CW) + 21.8506 Ln (DSH30)}
AGBFoliage = exp {-0.9496 + 0.5282 Ln (DSH30) + 2.3492 Ln (ρ) + 0.4286 Ln (CW)}
AGBTotal = exp {-1.8245 + 1.4358 Ln (DSH30) + 1.9921 Ln (ρ) + 0.6154 Ln (CW)}
The results of this study demonstrate that the development of local models derived from an appropriate sample of representative species can greatly improve the estimation of AGBTotal.
Raman spectroscopy of lymphocytes from patients with the Epstein-Barr virus infection
Authors: Pietruszewska Magdalena , Biesiada Grażyna , Czepiel Jacek , Birczyńska-Zych Malwina , Moskal Paulina , Garlicki Aleksander , Wesełucha-Birczyńska Aleksandra
Published: October 2023

In this study, Raman spectroscopy was applied to trace lymphocytes activation following contact with the Epstein-Barr virus (EBV) of the herpesvirus family. The biomarker of cell activation was found to be the 520 cm− 1 band, indicating formation of immunoglobulins. The blood samples were obtained from patients diagnosed with infectious mononucleosis and treated at the University Hospital in Kraków. The lymphocytes’ Raman spectra were collected using a mapping technique, exciting samples with a 514.5 nm line of Ar + laser. Measurements were performed on the 1st, 4th, 6th, 12th and 30th day of hospitalization, until the patient recovered. The highest intensity of the immunoglobulin marker was observed on the 4th day of hospitalization, while the results of the blood count of patients showed the greatest increase in the number of lymphocytes at the beginning of hospitalization. The blood of the healthy volunteers lacked activated lymphocytes. Some information was provided by the evaluation of B-cell activation by estimating the activated areas in the cells, which were determined by the presence of the Ig marker. The 900 cm− 1 band and band around 1450 cm− 1 were also analyzed as markers of the presence of the latent membrane protein, LMP2A (and 2B), of the EBV viral protein. The anomalous degree of depolarization observed in B-cells in the course of EBV infection appears to be due to the influence of a virus protein, disrupting BCR signal transduction.
Neuroprotective effects of CysLT2R antagonist on Angiostrongylus cantonensis-induced edema and meningoencephalitis
Authors: Chen Ke-Min , Lai Shih-Chan
Published: October 2023

Background
The pathogenesis of Angiostrongylus cantonensis-induced eosinophilic meningoencephalitis includes haemorrhage, brain edema formation, disrupting the blood–brain barrier (BBB), and induction of an inflammatory response. Cysteinyl leukotrienes (CysLTs) can induce a disruption of the BBB, and this reaction is mediated by cysteinyl-leukotriene receptors. In this study, we used A. cantonensis-induced eosinophilic meningoencephalitis as a model to investigate whether the CysLT2 receptor involved in the pathogenesis of angiostrongyliasis meningoencephalitis.
Methods
The brain edema was determined using the wet weight/dry weight method. Microglia polarization was detected by Flow cytometry and Enzyme-linked immunosorbent assay. Evans blue method was used to measure changes in the blood brain barrier, while western blotting was used to analyze BBB-related proteins. Gelatin zymography was used to assay matrix metalloproteinase-9 (MMP-9). MicroRNA expression was detected by Quantitative reverse transcription-PCR (qRT-PCR).
Results
The present study provides evidence that the CysLT2 receptor antagonist HAMI3379 reduced the number of infiltrated eosinophils and brain edema in eosinophilic meningoencephalitis. Additionally, we found that HAMI3379 significantly decreased the protein levels of M1 polarisation markers (CD80, iNOS, IL-5 and TNF-α), increased the expression of M2 polarisation markers (CD206, IL-10 and TGF-β) both in vivo and in vitro. Matrix metalloproteinase-9, S100B, GFAP, fibronectin, and claudin-5 were markedly lower after HAMI3379 treatment. Therefore, HAMI3379 reduced the BBB dysfunction in angiostrongyliasis meningoencephalitis. We have identified microRNA-155 as a BBB dysfunction marker in eosinophilic meningoencephalitis. The results showed that microRNA-155 was 15-fold upregulated in eosinophilic meningoencephalitis and 20-fold upregulated after HAMI3379 treatment.
Conclusions
Our results suggest that CysLT2R may be involved in A. cantonensis-induced brain edema and eosinophilic meningoencephalitis and that down-regulation of CysLT2R could be a novel and potential therapeutic strategy for the treatment of angiostrongyliasis meningoencephalitis.
A convenient and improved selection method for immortalisation of neural cells
Authors: Zheng Jian , Yao Yingling , He ling , Zhang Yanting , Bi Yang , Nan Guoxin
Published: October 2023

There is a wide variety of cells in the nervous system that collaborate with each other for information transfer, regulation and neuroprotection. Various cell investigations involving primary cells isolated from mammalian tissues are helpful in understanding disease pathophysiology. However, these cells are difficult to acquire in vitro in a short time and die of aging after repeated passages. These hurdles have hindered cell and disease research. Immortalized cell lines are necessary for cell research. After creating immortalized cell models, antibiotics are commonly employed to select immortalized cells. However, immortalized genes have poor transfection rates and a considerable percentage of non-immortalized cells are destroyed, shed, or are not harvested from suspension following antibiotic selection. Cells form a network of a variety of cell junctions. Consequently, when a large number of cells die and fall off, immortalized cells that were successfully transfected and had antibiotic resistance can also be removed, leaving only a small number of viable immortalized cells. Because of reciprocal nourishment between cells, when a few survive, their proliferation ability is also limited due to a lack of other cell secretion factors. Thus, obtaining immortalized cell lines takes more time. In this study, cells with transfected immortalized genes were cultured, subcultured, and selected. This process could generate stable immortalized cell lines in less time by enhancing the classic immortalized cell selection procedure. The feasibility and advantages of this method were demonstrated by infecting Schwann cells with retroviruses containing plasmid SSR#69 packaged in HEK293 cells. The resulting immortalized Schwann cell lines were compared to cells obtained by the standard screening before culture.
Identification of Potential Diagnostic and Prognostic Biomarkers for Cervical Cancer
Authors: Zhao Jinfei , Xia Xuemei , Dong Mimi
Published: October 2023

ObjectiveTo explore potential diagnostic and prognostic markers of cervical cancer by using GEO and TCGA databases.MethodsExpression matrices related to cervical cancer were downloaded from the GEO database. Gene expression and clinical-pathological data from TCGA and GTEx were obtained from the UCSC Xena database. Differentially expressed genes (DEGs) between normal and tumor tissue samples were identified using the limma package in R. DEGs were subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses using the ClusterProfiler package. The Cox proportional hazard regression model was used to screen significant genes. ROC curve and multivariate Cox regression analysis were used to evaluate the prognostic value of multiple clinical features.ResultsIn this study, 42 total DEGs were found, including 33 up-regulated genes and 9 down-regulated genes. GO analysis revealed that DEGs were involved in biological processes such as chromosomal segregation, nuclear division, and organelle fission. KEGG pathway analysis implicated Toll-like receptor and mismatch repair signaling pathways. 6 significant genes were identified by COX (p < 0.05) and CA9, GINS2, and SPP1 combined biomarkers divided cervical cancer patients into a high-risk group and a low-risk group. Moreover, the low-risk survival rate was significantly higher than the high-risk survival rate. Finally, multivariate Cox regression analysis showed that the combined biomarkers of CA9, GINS2, and SPP1 are independent predictors of the prognosis of cervical cancer patients.ConclusionThe GEO and TCGA databases screened out the combined biomarkers of CA9, GINS2, and SPP1, which are independent prognostic predictors of cervical cancer.
The use of multiple stent retrievers in emergent endovascular procedures; its predictors, associated costs and patient outcomes
Authors: Amankwah Curtis , Lombardo Lauren , Rutledge John , Sattar Ahsan , Chancellor Bree , Altschul Dorothea
Published: October 2023

Background and Purpose
The average annual cost of stroke treatment is over $40 billion in USA. With recent advancement of tools used in thrombectomies, the question of whether the use of multiple costly devices in an emergent thrombectomy will lead to a better or worse outcome when compared to simpler devices remains unanswered.
Materials and Methods
We retrospectively analyzed 89 patients who underwent emergent stroke interventions at a community hospital from January 2018 to February 2021. Patients were grouped into Aspiration only (ASP) n = 15, 1 Stent-retriever (SR) + 1ASP n = 59, and ≥ 1SR + ≥ 1ASP n = 15, based on main devices/device combination used that affected cost. Demographic and perioperative variables were assessed by multivariate analysis to determine possible predictors and outcomes associated with multiple device use (≥ 1SR + ≥ 1ASP).
Results
The multiple device/SR group had the highest mean total cost of devices per procedure (~$21,104) when compared to No SR/ASP only (~$4,477) and 1SR + 1ASP (~$12,295) groups. We identified LSW to puncture time (OR = 1.001; 95% CI 1.000 to 1.003, p = 0.05), and NIHSS score (OR = 1.085; 95% CI 1.085 to 1.173, p = 0.04) as significant predictors of multiple device use. Regarding outcomes, the use of multiple SR was significantly associated with poor/incomplete recanalization rates (OR = 0.191, 95% CI 0.049 to 0.741, p = 0.017) and functional dependence mRS 4–6 (OR=-1.02; 95% CI -2.04 to -0.01, p = 0.048).
Conclusions
After an unsuccessful initial attempt with a single device to achieve complete revascularization in EVTs, the additional use of stent-retrievers leads to unimproved recanalization rates at an increased cost with no additional clinical benefit to the patients. This was especially seen in patients who presented in the delayed time window (> 360 min) with high NIHSS scores.
Whole-brain connections of glutamatergic neurons in the lateral habenula in both sexes
Authors: Huang Hongren , Liu Xue , Wang Liping , Wang Feng
Published: October 2023

Background The lateral habenula (LHb) is an evolution-conserved epithalamic nucleus that plays a role in multiple physiological functions, such as encoding value signals, integrating emotional information, and regulating related behaviors. The cells within the LHb are predominantly glutamatergic and have heterogeneous functions in response to different stimuli. In addition, the circuitry connections of the LHb glutamatergic neurons anchor a vast array of event integration. However, circuitry connections of LHb glutamatergic neurons in both sexes have yet to be investigated.
Methods In this study, we microinjected Cre-dependent retrograde trace virus and anterograde synaptophysin-labeling virus into the LHb of adult male and female Vglut2-ires-Cre mice respectively and quantitatively analyzed the ipsilateral and contralateral whole-brain input as well as output of the LHb glutamatergic connections.
Results We found that the afferent of the LHbvGlut2 neurons involved more than 30 brain subregions, arising from the cortex, striatum, pallidum, thalamus, hypothalamus, midbrain, pons, medulla, and cerebellum without presenting significant sex differences. Additionally, the efferent of the LHbvGlut2 neurons consisted of eight parts of large brain regions, mainly targeting midbrain and pons nuclei, with distinct presynaptic bouton features across each brain subregion. Although correlation and cluster analysis revealed a different input and collateral projection feature, the input-output connection pattern of LHbvGlut2 neurons in both sexes was highly similar.
Conclusions This study systematically and comprehensively analyzed the whole brain input and output connections of the LHbvGlut2 neurons in male and female mice, providing insights into the anatomical architecture of the mouse cell-type-specific LHb neurons. This structural basis can guide investigations into the complex functions of the LHb.
Experimental Anaysis on the Effects of Trace Metals as Micronutrients in Enhancing Biomethane Production
Authors: C Tintu Mary , K Swarnalatha , J Harishma S.
Published: October 2023

Anaerobic digestion (AD) of microbial biomass has proven to be a significant breakthrough technique in producing biogas rich in methane. The quantity of biogas produced by anaerobic digestion processes varies significantly based on the nature and characteristics of substrates used. Although various substrates have been studied to produce biogas rich in biomethane by various methods, studies using micronutrients for enhancing biomethane production are less explored. This research work focusses the use of trace metals such as Fe, Cu, Zn, Mn, Mg, Ni in proper proportions to enhance the microbial consortium thus aiding in the production of methane of desired quality. Initial parameter analysis of the samples was done based on specific dosages of the micronutrients supplied to the reactor. The effect of these micronutrients on the anaerobic digestion process was observed by analysing the biogas yield, pH, alkalinity, total solids, and volatile solids of the samples. Studies were done on daily basis in triplicate samples to arrive at concordant results. Once the minimum dosage was formulated the nutrient supplementation was done on varying dosages for improving the biomethane potential of the samples. Food waste from the college canteen was used as the substrate and cow dung was used as an inoculum for providing a catalytic effect in the anaerobic reactor. An energy balanced microbial reactor set up was developed for varying proportions of metals used as micronutrients. Further studies showed a drastic decrease in Volatile Fatty Acids (VFA) accumulation in the anaerobic reactor with increase in retention period which proves the stability of the system in the long run. The results obtained from this study shows an effective method for conversion of waste to energy in less time and in achieving sustainable development goals for treating waste.
Archaeological cognition of the Eastern Mausoleum of Qin State using integrated space-ground observation tools
Authors: Luo Yansong , Chen Fulong , Gao Sheng , Zhu Meng , Zhou Wei , Elfadaly Abdelaziz
Published: October 2023

As a significant component of the Qin Dynasty's royal tombs, the ruins from the Eastern Mausoleum of the Qin State would be mirrored to present the social development level during the Warring States period (475 BC ~ 221 BC) in China. In this study, we applied multi-mode space-ground observations and derivative Digital Elevation Models to assess the plausibility of Remote Sensing (RS) in archaeology and to uncover the hitherto poorly understood conditions/situations for heritage conservation. We first applied the ‘Normalized Difference Vegetation Index’ and the ‘Normalized Difference Moisture Index’ to highlight archaeological traces. Additionally, for the first time, we proposed utilizing thermal infrared band data from the SDGSAT-1 satellite for the exploration of thermal archaeological traces, revealing an enhancement in archaeological signs. Subsequently, we use electromagnetic prospecting to confirm the presence of an ancient tomb passage. The landscape analysis reveals the hold of the Chinese Geomancy Theory on the site selection for royal tombs, this philosophy in turn is significant for heritage conservation from the natural force of surface erosion. The RS-based change detection using CORONA and Google Earth images reveals negligible surface erosion traces along with the mitigated anthropogenic disturbance. This study implies the potential of multi-mode space-ground observations for the cultural heritage archaeological value exploitation as well as the sustainable conservation of these irreplaceable properties.
Risk factors for Herpes Zoster infections– a systematic review and meta-analysis unveiling common trends and heterogeneity patterns
Authors: Steinmann Maren , Lampe David , Grosser John , Schmidt Juliana , Hohoff Marla-Louise , Fischer Anita , Greiner Wolfgang
Published: October 2023

Purpose:
The burden of herpes zoster (HZ) is substantial and numerous chronic underlying conditions are known as predisposing risk factors for HZ onset. Thus, a comprehensive study is needed to synthesize existing evidence. This study aims to comprehensively identify these risk factors.
Methods:
A systematic literature search was done using MEDLINE via PubMed, EMBASE and Web of Science for studies published from January 1, 2003-January 1, 2023. Eligible studies were case-control or cohort studies. A random-effects model and multiple meta-regression were used to summarize the odds ratios (OR) with a 95% confidence interval (CI). Heterogeneity was analyzed with influence analyses.
Results:
Of 6,392 considered records, 80 were included in the meta-analysis. 21 different conditions were identified as potential risk factors for HZ. Transplantation was associated with the highest risk for HZ with a pooled OR = 4.51 (95% CI [1.9–10.7]). Other risk factors ranged from OR = 1.17–2.87, indicating an increased risk for all underlying conditions included in these analyses. Heterogeneity was substantial in all provided analyses. Sensitivity analyses showed comparable results regarding the pooled effect estimates and heterogeneity.
Conclusions:
We identified 21 potential risk factors: asthma, autoimmune disorders, cancer, cardiovascular disorders, chronic heart failure (CHF), COPD, depression, diabetes, digestive disorders, endocrine and metabolic disorders, hematological disorders, HIV, inflammatory bowel disease (IBD), mental health conditions, musculoskeletal disorders, neurological disorders, psoriasis, renal disorders, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and transplantation. This study showed an increased risk for HZ infections for all identified factors.
Growth Performance, Enzymatic Activities, Haematology and Serum Biochemistry of Clarias Gariepinus Fed Thermally Processed Jatropha Curcas Kernel Meal Based Diets
Authors: Jimoh Jeremiah Olanipekun , Omitoyin Bamidele Oluwarotimi , Ajani Emmanuel Kolawole , Liew Hon Jung , Rahmah Sharifah , Okomoda Victor Tosin , Mohamad Siti Jalilah , Omobepade Bayode Paul , Ola Lidya , Fabusoro Abiola Ayodeji , Olasunkanmi John Bunmi , Ayegba Emmanuel Omachi
Published: October 2023

Jatropha curcaskernel meal is an agro-industrial by-product that is rich in essential nutrients that can be utilized by fish for optimal growth. The toxic substance and anti-nutritional factors (ANFs) must be removed to unlock its dietary potential. This study attempted to reduce the ANFs and improve the nutritional quality ofJ. curcasusing autoclaving while the end product was used to replace soybean meal at 25%, 50%, 75% and 100% (TTR25, TTR50, TTR75 and TTR100 respectively) with the control (SBM) in prepared diets (40% CP) ofClarias gariepinusjuveniles (n = 150, average initial weight = 18.21g). The results showed that thermal treatment reduced significantly the phorbol ester and other ANFs contents inJ. curcasmeal. However, the changes in the proximate compositions save for lipid content were insignificant. Further results after 63 days feeding trial showed that fish fed 25% (TTR25)J. curcashad the best weight gain (111.99 ± 14.53), feed conversion ratio (1.11 ± 0.16), protein efficiency ratio (1.41 ± 0.22) and survival rate (86.67 ± 11.55). Similar results were obtained in haematology, serum biochemistry and protease activity analysis with TTR25 fish emerging with the best results. However, the amylase and lipase activity results revealed that TTR75 and SBM fish had the best activities respectively. However, the results were not significantly different from that of TTR25. It is therefore concluded thatJ. curcaskernel meal can be rid of toxic substances and anti-nutrients through autoclaving while 25% replacement of soybeans withJ. curcaskernel meal is recommended in the diet ofClarias gariepinusjuveniles.
Animal supplementation and forage legume in an integrated crop-livestock systems: nitrogen export by animals, cycling, and soybean productivity
Authors: Danna Mirella , Scheeren Fernanda , Sartor Laercio Ricardo , Menezes Luis Fernando Glasenapp , Paris Wagner , Andriotti Nathalia , Garrett Caio Emanuell
Published: October 2023

Animal supplementation and grass-legume mixture can increase the stocking rate and crop and animal waste in the soil. Our hypothesis is that these alternatives can increase the amount of nitrogen recycled in an integrated crop-livestock system. We analyzed in an integrated crop­livestock system, whether the nitrogen recycling and the soybean crops are influenced by legume and animal supplementation (1% live weight) in beef cattle production. We evaluated animal nitrogen intake, the recycled through feces and urine, and the amount of nitrogen retained in beef cattle carcass. In summer, the rate of dry matter, and nutrient release from the residual biomass after grazing and feces of animals, the export of nitrogen by soybean crops, and grain production. It was possible to increase the stocking rate in 21% through supplementation and with this there was a 33% increase in the return of nitrogen through feces and urine compared to the control. This result interfered with the export of nitrogen in grains, which was 9% higher in paddocks where there was animal supplementation. The amount of nitrogen exporting by the animals, in 90 days of grazing, did not differ between treatments, averaging 8.18 kg ha− 1 of N. Nitrogen return in a complete cycle increased by 19%, where animal and legume supplementation was used. We concluded that the supplementation and use of legumes are alternatives to increase the nitrogen recycled in integrated farming systems. Of the total N exporting, about 3 to 4% are through animals, and 96 to 97% are through soybean grains.
Long-Term Surgical Outcomes of Pediatric Retinal Detachment Associated with Congenital Glaucoma
Authors: Artunay Ozgur , Ozbek Merve
Published: October 2023

Purpose
Congenital glaucoma (CG) is an extremely rare disease with an incidence of one in 10,000 live births. Increasing axial length due to CG predisposes to retinal thinning and retinal detachment (RD). The aim of the present study is to determine the long-term surgical outcomes of pediatric RD associated with CG.
Methods
This was a retrospective study including pediatric patients who underwent vitrectomy with silicone oil injection for RD associated with CG. Ocular examination reports and surgical findings of patients were analyzed to assess for the anatomical and functional outcomes of the surgery.
Results
The study included 20 eyes of 20 children. Mean age was 10.35 ± 3.73 years, range 5–16 years. Mean axial length was 26.10 ± 2.19 mm (range, 20.31–28.91 mm). In 11 eyes, the intraocular pressure was < 6 mmHg at the time of RD diagnosis. The mean logarithm of the minimum angle of resolution (logMAR) visual acuity improved from 2.13 ± 0.45 to 2.02 ± 0.61 (p = 0.477) after surgery. Mean follow-up period was 24.55 ± 10.01 months, range 12–48 months. During the follow-up period, 6 patients (30%) had revision of surgery due to recurrent RD. Globe survival has been achieved in 19 out of 20 eyes (95%).
Conclusion
Ocular comorbidities play a significant role in limiting final visual outcomes. Despite the poor visual prognosis of surgery, globe survival can achieve in such cases. Globe preservation has an important impact on patients’ quality of life, psychological and social functionality. Moreover, ambulatory vision can be preserved in most eyes.
The Value of Multimodal Treatment in Anaplastic Thyroid Cancer Patients with Distant Metastasis
Authors: Guo Hongen , Lin Hanqing
Published: October 2023

Background
Anaplastic thyroid cancer (ATC) is a rare and aggressive malignancy with a poor prognosis, particularly in patients presenting with distant metastasis (DM). This study aimed to assess the effect of combination treatment strategies on survival in ATC patients with DM.
Methods
A retrospective analysis was conducted using data from the Surveillance, Epidemiology, and End Results (SEER) database to identify primary ATC cases with DM at diagnosis. Univariate and multivariate Cox proportional hazards regression analyses were performed to identify independent risk factors for survival.
Results
Of the 315 ATC patients with DM included in the study, surgery to the primary tumor, radiotherapy, chemotherapy, and lung metastasis were identified as independent risk factors for survival. Patients who received primary tumor surgery plus chemotherapy or surgery plus chemoradiation exhibited a superior outcome compared to those who received only one treatment modality.
Conclusion
Our findings suggest that a combination treatment approach, particularly surgery combined with radiotherapy or surgery combined with chemoradiotherapy, may provide the most optimal treatment option for ATC patients with DM. These results may inform clinical decision-making and improve patient outcomes in this challenging disease setting.
Trends in Worldwide research on laser in ophthalmology over the period 1990-2022: A bibliometric study of hotspots, nodes, bursts, and trends
Authors: Jiang Yaping , Cai Yuying , Zhang Xin , Chen Li , Zhou Xingtao , Chen Yihui
Published: October 2023

Background
Laser therapy has been proven as an effective technique for managing ophthalmological disorders. To guide future research, we conducted a bibliometric analysis of laser applications in eye diseases from 1990 to 2022, aiming to identify key themes and trends.
Methods
we retrieved 3027 publications from the Web of Science Core Collection (WoSCC). Bibliometrix was used for science mapping of the literature, while VOSviewer and CiteSpace were applied to visualize co-authorship, co-citation, co-occurrence, and bibliographic coupling networks.
Results
From a co-citation reference network, we identified 52 distinct clusters. Our analysis uncovered three main research trends. The first trend revolves around the potential evolution of corneal laser surgery techniques, shifting from the treatment of refractive errors to broader applications in biomedical optics. The second trend illustrates the advancement of laser applications in treating a range of disorders, from retinal and ocular surface diseases to glaucoma. The third trend focuses on the innovative uses of established technologies.
Conclusions
This study offers significant insights into the evolution of laser applications in ophthalmology over the past 30 years, which will undoubtedly assist scientists in directing further research in this promising field.
Diabetic Foot Care and Screening Practices among Iranian Nursing Students: A Cross-Sectional Survey in Teaching Hospitals of Tabriz
Authors: Moghadam Aylar , Attari Ahmad Mirza Aghazadeh , Zamanzadeh Vahid , Lotfi Mojgan
Published: October 2023

Background Diabetic foot ulcers (DFUs) are a serious complication of diabetes that can lead to amputation and reduced quality of life. Nurses play a vital role in preventing and managing DFUs by educating, assessing, and caring for diabetic patients. Nursing students, as future health care providers, need to have adequate knowledge, attitudes, and practices regarding diabetic foot care and screening. However, there is a lack of studies on these factors among nursing students in Iran.Methods This was a cross-sectional study conducted in 2022. The sample consisted of 200 nursing students from the Tabriz Faculty of Nursing and Midwifery. Data were collected using a questionnaire that included demographic and occupational characteristics, a knowledge questionnaire, an attitude questionnaire, and a diabetic foot screening checklist. Data were analyzed using SPSS 22 software.Results The results showed that approximately 55% of the students had relatively good knowledge, 49% had a positive attitude, and 7.5% had very good practices regarding diabetic foot care and screening. However, more than half of the students had poor knowledge or practice, and some of them considered diabetic foot care to be time-consuming.Conclusion The findings of this study revealed that the nursing students had received previous education about diabetic foot care management, but their knowledge and practice were still inadequate. Their attitude was generally positive, but some barriers existed for translating it into clinical practice. These results suggest that there is a need to improve the curriculum and training methods for nursing students regarding diabetic foot care management and screening. This can enhance their competence and confidence in providing quality care to diabetic patients and preventing DFUs and amputations.
Adaptation of an entrepreneurship education self-assessment scale at the tertiary level into Turkish
Authors: ÇELİK Ahmet , SOLMAZ Ebru
Published: October 2023

The university environment provides a good context for entrepreneurship education. With the vigorous development of entrepreneurship education, educators and scholars have shown increasing interest in the significant role entrepreneurship education plays in higher education. As a result, the effectiveness of entrepreneurship education has quickly become a popular topic. However, it is often not easy to evaluate entrepreneurship education programs, which are designed for medium- and long-term outcomes. It is essential to develop alternative assessment tools that do not traditionally assess only knowledge. The study aims to adapt the multidimensional measurement tool for assessing university students' entrepreneurial skills, knowledge, attitudes, and mindsets. While the scale was translated into Turkish, face and content validity were proved. The data was gathered from 572 university students. Confirmatory factor analyses were employed to assess the construct validity of the measure. The Turkish Entrepreneurship Education Self-Efficiency Scale was obtained with three main dimensions and 38 items. Its Cronbach’s alpha, Spearman-Brown correlation, and composite reliability coefficients are 0.95, 0.86, and 0.98, respectively. Furthermore, the study found that the entrepreneurship education scores of the participants were significantly related to their gender, field of education, volunteering, work experience, experience of starting or running their own business, and entrepreneurship education. The effect size of these variables differs, and the experience with self-employment has the greatest influence on entrepreneurship education.
Language Policies and Minority Language Maintenance: The Case of Circassian in Turkey
Authors: PSHİGUSA Emre
Published: October 2023

Guided by language maintenance and shift (Fishman, 1991) as a theoretical construct, this study explored the sociolinguistic situation and the maintenance of Circassian, a Northwest Caucasian language, spoken in Turkey since the Ottoman Era. To explore the impacts of official language ideologies and policies on the maintenance of Circassian, five participants from different age groups and regions of Turkey were interviewed using linguistic life story interviews (Atkinson 1998). As part of its socio-historical focus, the study first highlights some of the Circassian initiatives that played an important role in maintaining the language during the Ottoman Era and addresses the changes in language ideologies and policies after the declaration of the Turkish Republic. Similar to other ethnolinguistic minorities' experiences in Turkey (Aslan, 2007; Seloni & Sarfati, 2013), the life story interviews revealed the impacts of assimilationist language policies in educational and social settings. Findings also revealed the long-lasting impact of the Citizen Speak Turkish policy (1928-1945) on the maintenance of Circassian and its negative impact on the generational transfer which has not been explored by former research. The findings have implications for language policymakers, Circassian NGOs, and Circassian speakers in Turkey to maintain and transfer the language to future generations.
Parametrik Tasarım Yaklaşımının Sofra Seramiği Dekor ve Form Tasarımlarına Yansımasının İncelenmesi
Authors: Parlak Demet , Mercin Levent
Published: October 2023

Tasarım, insanların ihtiyaçlarını karşılamak üzere ortaya çıkan kullanışlı, estetik ve yenilik getirici ürün ortaya koyma sürecinin ilk adımıdır. Tasarım alanından biri olan endüstriyel tasarım ile ürünler ve kullanıcılar arasında fiziksel ve fonksiyonel ilişki kurulabilmektedir. Son dönemlerde popüler tasarım çeşidinden biri olan parametrik tasarım, birçok değişkenin tasarımı şekillendirilmesiyle oluşmaktadır. Bu değişkenler arasında matematiksel, kullanıcı ve çevresel gibi parametreler mevcuttur. Parametrik tasarım, yaygın olarak mimarlık alanında kullanılmakla birlikte birçok endüstriyel ürün tasarımında da yararlanılmaktadır. Bu tasarım yaklaşımının hem diğer alanlardaki hem de sofra seramiği sektöründeki kullanım biçimlerinin incelenmesi ve elde edilen verilere göre özgün ürünler ortaya konulması bir ihtiyaç olarak kabul edilmiştir. Araştırmada literatür taraması, eser ve ürün analizi ile özgün tasarımların ortaya konulması yöntemlerinden yararlanılmıştır. Araştırmada genel olarak parametrik tasarım örnekleri incelenmiş, ancak sadece özgün sofra seramiği tasarımları hazırlanması ile sınırlandırılmıştır. Özgün parametrik tasarım örnekleri, sofra seramiği sektöründe yaşanan rekabet ortamında, ürün tasarımlarına yeni bir boyut kazandırdığı, özgün ürünlerin ortaya konulmasını sağladığı, tasarım kültürüne bir zenginlik kattığı sonucuna ulaşılmıştır.
İplik Tasarımında İnovasyonun Tekstil ve Moda Tasarımına Katkısı
Authors: Tokgöz Suzan
Published: October 2023

Tarihsel süreçte tekstil ve hazır giyim sektörü, sanat, tasarım, mühendislik, malzeme bilimi gibi farklı disiplinlerdeki gelişimlerin görünür olmasında aracı olmuştur. Moda, tekstil ve giyim, farklı, alışılmışın dışında olan malzemeler ile tekniklerin kullanımına en uygun alanların başında gelirken, yenilikçi gelişmelerin sonunda farklı alanlara hizmet etmeye başlamıştır. Bu araştırmada, tekstilde iplik tasarımının estetik ve işlevsel unsurlar sentezinde, moda ve tekstil tasarımına etkisi sorgulanmış, çağımızın gereksinimi yenilikçi ürün geliştirme çalışmalarında, öncelikli tasarımcı rolünün önemi ve bütünsel olarak konumlandırılma gerekliliği ele alınmıştır.
Çalışma içerisinde, iplik tasarımının yeniyi ortaya çıkarmada ki kavramsal önemi amaçlanarak inovasyon ele alınmıştır. Koleksiyon ve ürün tasarım süreci içerisinde, tasarım nesnesi ipliğin mevcut potansiyeli, kazanımları, dikkate alınarak katkı sağlamaya ilişkin tasarım örneklerine yer verilmiştir. Yenilik yaratımında, belirleyici unsur olarak görülebileceği ifade edilmiş, çalışmanın amacına yönelik tekstil ve moda ürün tasarımı görselleri ile literatür araştırmaları, günümüzün tasarım anlayışı ile tasarımcılara katkı sağlayacak, nitelikli, yenilikçi, tasarım çalışmaların ortaya konması amaçlanarak değerlendirilmiştir.
Learning mathematics through experience
Authors: Anh Nguyen Mai , Duong Nguyen Thuy
Published: October 2023

The aim of this research is to explore the application of experiential mathematics education to enhance the enthusiasm of second-grade students in the context of Vietnamese education. The research methodology is based on conducting a specific theoretical study of the benefits of experiential mathematics education and the significance of mathematical enthusiasm. This paper provides an overview of the theory of experiential mathematics education, focusing on understanding the importance of mathematical enthusiasm in the teaching process and evaluating the current state of mathematics education for second-grade students in Vietnam. The research results emphasize that learning mathematics through experience can create an exciting and effective learning environment for second-grade students. This method helps them grasp mathematical knowledge with greater enthusiasm and provides opportunities for active participation in the learning process. However, it also poses some challenges in implementation, such as adapting to the Vietnamese educational context and ensuring that teachers have the knowledge and skills to effectively apply this method. In conclusion, this paper's research highlights the importance of applying experiential mathematics education to enhance the mathematical enthusiasm of second-grade students in Vietnam and provides theoretical foundations for its effective implementation in the Vietnamese educational environment.
A Dialectical Analysis on Upgrading Underdeveloped Guangdong Agriculture with Digital Ecological Industry
Authors: Qing Luo , Shihan Jiang , Xinyu Tang
Published: October 2023

The upgrading of underdeveloped Guangdong agriculture is analysed by Materialist dialectics. Agriculture should not be seen as a symbol of backwardness, but rather as an important ecological industry that can be upgraded with advanced digital science and technology. Cognitive innovation and environmental innovation are emphasized in attracting innovative talents and supporting digital ecological industry. The upgrading path of the digital ecological industry highlights top-level design and systematic planning. Overall, the document emphasizes the strategic value of agriculture and the potential for Guangdong to play a dominant role in the Regional Comprehensive Economic Partnership (RCEP) through digital ecological industry upgrading. Digitalization may enable Guangdong integrate agriculture, industry, and service industries to achieve ecological civilization.
EXPERIÊNCIAS E APROXIMAÇÕES TEÓRICO-PRÁTICAS DE MULHERES QUILOMBOLAS DA AMAZÔNIA PARAENSE COM O ECOFEMINISMO
Authors: Rodrigues da Silva Miranda Ellen , Girão Soares de Lima Maria Jacqueline
Published: October 2023

Expomos neste artigo, a partir de achados de uma pesquisa de mestrado concluída e pesquisas em andamento, a relação entre mulheres quilombolas, natureza e sociedade como processo de aproximação entre teoria e práxis interseccional ecofeminista na Amazônia Paraense. Ancoradas na abordagem qualitativa de enfoque materialista histórico-dialético, analisamos observações, anotações de campo e entrevistas semiestruturadas. As aproximações são apontadas em experiências de luta cotidiana ao realizarem ações contra as investidas de privatizações dos rios, florestas e animais, operadas pelo capitalismo.
Palavras-chave: Mulheres quilombolas; Experiência; Natureza-território; Interseccionalidade; Ecofeminismo.
MOVIMIENTO AGROECOLÓGICO “CAMPESINO A CAMPESINO”: EXPERIENCIAS, PARTICIPACIÓN POPULAR Y CUESTIONES SOCIOAMBIENTALES EN CUBA
Authors: Pérez García Jesus Jorge
Published: October 2023

En el texto presentamos resultados de la investigación del doctorado realizada en comunidades rurales en Cuba (2010 – 2015).Tomando o materialismo histórico dialéctico como método, a partir das categorías memoria y experiencia desde la revolución cubana hasta la actualidad; considerando los legados de generaciones como: campesinos y líderes revolucionarios, simientes de un proceso de construcción colectiva que atendió la formación de los recursos humanos y ubicó al hombre en sitial prioritario, con métodos de participación colectiva, en articulación con los adelantos de la técnica, la ciencia y la preservación del medio ambiente en equilibrio entre la sociedad-naturaleza-economía.
Palabras-clave: Agroecología. Campesino-campesino. Socio ambiental. Participación.
CONTRADIÇÕES ENTRE TRABALHO, CAPITAL E VIDA: “A ASSIM CHAMADA ACUMULAÇÃO PRIMITIVA” E SUA ATUALIDADE HISTÓRICA
Authors: Aquino Mahalia , Tiriba Lia
Published: October 2023

São analisados trechos do capítulo XXIV de O capital, de Karl Marx (2013), articulando-os à problemática das relações seres humanos/ natureza mediadas pela produção destrutiva do capital e, em particular, pelas políticas anti-ambientais do governo Jair Bolsonaro. Destaca-se a importância da obra no atual momento em que o agronegócio e neoextrativismo destroem a flora e a fauna, desestruturando os modos de vida de povos e comunidades tradicionais. Conclui-se que “a assim chamada acumulação primitiva” pode ser considerada como acumulação permanente do capital, e que os crimes ambientais têm levado às últimas consequências as contradições entre trabalho, capital e vida.
Palavras-chave: Karl Marx. Acumulação primitiva. Crime ambiental.
VIAGEM DE CAMPO: A EXTENSÃO DO CRIME AMBIENTAL NA BACIA DO RIO DOCE
Authors: Gomes de Carvalho Aquino Mahalia
Published: October 2023

Para essa reportagem fotográfica apresentada a Revista Trabalho Necessário, o lócus da viagem de campo consiste na Bacia do Rio Doce, região diretamente atingida pelo crime ambiental que repercutiu no rompimento de uma das barragens de rejeitos minerários do Complexo de Germano: Fundão (Mariana – MG), em novembro de 2015. A barragem é de responsabilidade da mineradora Samarco e suas acionistas, as multinacionais extrativistas Vale e BHP Billiton. Busca-se com esta reportagem fotográfica evidenciar o meio ambiente da Bacia do Rio Doce após o crime do rompimento da barragem de Fundão e de como esse ambiente não favorece, ou não propicia mais, as condições necessárias para a realização do trabalho com a pesca e com a terra.