bluuebunny/crossref_metadata_2025 huggingface dataset:
Phytochemical Screening and Bioactivities of Cactaceae Family Members Endemic to Mexico
Authors: Rodríguez-Mendoza Clara Angélica , González Campos Rubí Esmeralda , Lorenzo-Leal Ana Cecilia , Bautista Rodríguez Elizabeth , Paredes Juárez Genaro Alberto , El Kassis Elie Girgis , Hernández Luis Ricardo , Juárez Zaida Nelly , Bach Horacio
Published: October 2022

Mexico is a center of diversification for the Cactaceae family, with 69% of the species recorded as endemic. Certain members of the Cactaceae family have been chemically analyzed to relate their medicinal use with their phytochemistry. Here, the phytochemistry and bioactivity of ethanol extracts of Ferocactus echidne, F. latispinus, and Mammillaria geminispina were evaluated. A preliminary phytochemical analysis was performed, detecting the presence of saponins, tannins, cardiotonic glycosides, and sesquiterpene lactones. The presence of nicotinic acid in F. echidne and F. latispinus was identified by GC-MS. Other compounds found in the extracts of these three species were gentisic acid, diosmetin, chlorogenic acid, N-methyltyramide, and hordenine. The antioxidant activity was estimated with the DPPH free radical scavenging test. To determine the toxicity of the extracts, the in vivo model of Artemia spp. was used. In addition, the cytotoxicity of the extract was tested on C6, HaCaT, THP-1, and U937 cell lines, while the inflammatory activity was tested by measuring the secretion of cytokines using macrophage cells. The three species showed different bioactivities, including antioxidant, antimicrobial, cytotoxic, and anti-inflammatory activities. To the best of our knowledge, the results presented here are the first described for these species.
Mechanistic Concept of Physiological, Biochemical, and Molecular Responses of the Potato Crop to Heat and Drought Stress
Authors: Lal Milan Kumar , Tiwari Rahul Kumar , Kumar Awadhesh , Dey Abhijit , Kumar Ravinder , Kumar Dharmendra , Jaiswal Arvind , Changan Sushil Sudhakar , Raigond Pinky , Dutt Som , Luthra Satish Kumar , Mandal Sayanti , Singh Madan Pal , Paul Vijay , Singh Brajesh
Published: October 2022

Most cultivated potatoes are tetraploid, and the tuber is the main economic part that is consumed due to its calorific and nutritional values. Recent trends in climate change led to the frequent occurrence of heat and drought stress in major potato-growing regions worldwide. The optimum temperature for tuber production is 15–20 °C. High-temperature and water-deficient conditions during the growing season result in several morphological, physiological, biochemical, and molecular alterations. The morphological changes under stress conditions may affect the process of stolon formation, tuberization, and bulking, ultimately affecting the tuber yield. This condition also affects the physiological responses, including an imbalance in the allocation of photoassimilates, respiration, water use efficiency, transpiration, carbon partitioning, and the source–sink relationship. The biochemical responses under stress conditions involve maintaining ionic homeostasis, synthesizing heat shock proteins, achieving osmolyte balance, and generating reactive oxygen species, ultimately affecting various biochemical pathways. Different networks that include both gene regulation and transcription factors are involved at the molecular level due to the combination of hot and water-deficient conditions. This article attempts to present an integrative content of physio-biochemical and molecular responses under the combined effects of heat and drought, prominent factors in climate change. Taking into account all of these aspects and responses, there is an immediate need for comprehensive screening of germplasm and the application of appropriate approaches and tactics to produce potato cultivars that perform well under drought and in heat-affected areas.
Phytochemical Characterization of Water Avens (Geum rivale L.) Extracts: Structure Assignment and Biological Activity of the Major Phenolic Constituents
Authors: Orlova Anastasia , Kysil Elana , Tsvetkova Elena , Meshalkina Darya , Whaley Andrei , Whaley Anastasiia O. , Laub Annegret , Francioso Antonio , Babich Olga , Wessjohann Ludger A. , Mosca Luciana , Frolov Andrej , Povydysh Maria
Published: October 2022

Water avens (Geum rivale L.) is a common Rosaceae plant widely spread in Europe and North America. It is rich in biologically active natural products, some of which are promising as prospective pharmaceuticals. The extracts of water avens are well known for their triterpenoid metabolites and associated anti-inflammatory, antimicrobial and antioxidant activities. However, the polyphenolic profiles of G. rivale L. are still awaiting complete characterization. Accordingly, the contribution of its individual components to the antioxidant, antibacterial and neuroprotective activity of the extracts is still unknown. As this plant can be available on an industrial scale, a better knowledge of its properly-relevant constituents might give access to new highly-efficient pharmaceutical substances and functional products. Therefore, herein we comprehensively characterize the secondary metabolome of G. rivale by ESI-HR-MS, ESI-HR-MSn and NMR spectroscopy with a special emphasis on the polyphenolic composition of its aerial parts. Furthermore, a multilateral evaluation of the antioxidant, neuroprotective and antibacterial properties of the aqueous and ethyl acetate fractions of the total aqueous alcoholic extract as well as individual isolated polyphenols was accomplished. Altogether four phenolic acid derivatives (trigalloyl hexose, caffeoyl-hexoside malate, ellagic acid and ellagic acid pentoside), six flavonoids (three quercetin derivatives, kaempferol and three its derivatives and two isorhamnetin derivatives) and four tannins (HHDP-hexoside, proantocyanidin dimer, pedunculagin I and galloyl-bis-HHDP-hexose) were identified in this plant for the first time. The obtained aqueous and ethyl acetate fractions of the total extract as well as the isolated individual compounds showed pronounced antioxidant activity. In addition, a pronounced antibacterial activity against several strains was proved for the studied fractions (for ethyl acetate fraction the highest activity against E. coli АТСС 25922 and S. aureus strains ATCC 27853 and SG-511 (MIC 15.6 μg/mL) was observed; for aqueous fraction—against Staphylococcus aureus SG-511 (MIC 31.2 μg/mL)). However, the anti-neurodegenerative (neuroprotective) properties could not be found with the employed methods. However, the antibacterial activity of the fractions could not be associated with any of the isolated individual major phenolics (excepting 3-O-methylellagic acid). Thus, the aerial parts of water avens represent a promising source of polyphenolic compounds with antioxidant activity and therefrom derived human health benefits, although the single constituents isolated so far lack a dominant selectively bioactive constituent in the bioassays performed.
The Preliminary Assessment of New Biomaterials Necessitates a Comparison of Direct and Indirect Cytotoxicity Methodological Approaches
Authors: Chraniuk Milena , Panasiuk Mirosława , Hovhannisyan Lilit , Żołędowska Sabina , Nidzworski Dawid , Ciołek Lidia , Woźniak Anna , Jaegermann Zbigniew , Biernat Monika , Gromadzka Beata
Published: October 2022

Background: Cytotoxicity testing is a primary method to establish the safety of biomaterials, e.g., biocomposites. Biomaterials involve a wide range of medical materials, which are usually solid materials and are used in bone regeneration, cardiology, or dermatology. Current advancements in science and technology provide several standard cytotoxicity testing methods that are sufficiently sensitive to detect various levels of cellular toxicity, i.e., from low to high. The aim was to compare the direct and indirect methodology described in the ISO guidelines UNE-EN ISO 10993-5:2009 Part 5. Methods: Cell proliferation was measured using WST-1 assay, and cytotoxicity was measured using LDH test kit. Results: The results indicate that the molecular surface of biomaterials have impact on the cytotoxicity and proliferation profile. Based on these results, we confirm that the indirect method does not provide a clear picture of the cell condition after the exposure to the surface, and moreover, cannot provide complete results about the effects of the material. Conclusions: Comparison of both methods shows that it is pivotal to investigate biomaterials at the very early stages using both indirect and direct methods to access the influence of the released toxins and surface of the material on the cell condition.
Rigid Polyurethane Biofoams Filled with Chemically Compatible Fruit Peels
Authors: Acosta Andrey Pereira , Otoni Caio Gomide , Missio André Luiz , Amico Sandro Campos , Delucis Rafael de Avila
Published: October 2022

Banana and bergamot peels are underutilized byproducts of the essential oil and juice-processing industry. This study was designed for the development of rigid polyurethane foam (RPUF) composites using polysaccharide-rich fruit peels as fillers. These fillers were characterized for chemical properties using wet analyses. Additionally, the influences of the filler type and filler content on morphological, thermal, mechanical, hygroscopic, and colorimetric properties of the RPUF were investigated. The main results indicated that, in a comparison with the neat RPUF, the insertion of up to 15% of fillers yielded similar water uptake, apparent density, compressive strength, and color properties, as well as increases up to 115% in thermal stability and up to 80% in cell size.
Conformation and Structure of Hydroxyethyl Cellulose Ether with a Wide Range of Average Molar Masses in Aqueous Solutions
Authors: Yoshida Misato , Iwase Hiroki , Shikata Toshiyuki
Published: October 2022

The solution properties of a water-soluble chemically modified cellulose ether, hydroxyethyl cellulose (HeC), were examined using static light scattering (SLS), dynamic light scattering (DLS), small-to-wide-angle neutron scattering (S-WANS), small-to-wide-angle X-ray scattering (S-WAXS) and viscometric techniques at 25 °C. The examined HeC samples had average molar substitution numbers ranging from 2.36 to 2.41 and weight average molar masses (Mw) that fell within a wide range from 87 to 1500 kg mol−1. Although the relationship between the determined radius of gyration (Rg) and Mw was described as Rg ∝ Mw~0.6, as is observed usually in flexible polymer solutions in good solvents, the observed scattering vector (q) dependencies of excess Rayleigh ratios were well interpreted using a rigid rod particle model, even in high-Mw samples. Moreover, the ratios of the formed particle length (L) evaluated assuming the model for rigid rods to the determined Rg showed the relationship LRg−1 ~ 3.5 irrespective of Mw and were close to those theoretically predicted for rigid rod particle systems, i.e., LRg−1 = 12. The observed SLS behavior suggested that HeC molecules behave just like rigid rods in aqueous solution. As the L values were not simply proportional to the average molecular contour length calculated from the Mw, the chain conformation or structure of the formed particles by HeC molecules in aqueous solution changed with increasing Mw. The q dependencies of excess scattering intensities observed using the S-WANS and S-WAXS experiments demonstrated that HeC molecules with Mw less than 200 kg mol−1 have a diameter of ~1.4 nm and possess an extended rigid rod-like local structure, the size of which increases gradually with increasing Mw. The observed Mw dependencies of the translational and rotational diffusion coefficients and the intrinsic viscosity of the particle suspensions strongly support the idea that the HeC molecules behave as rigid rod particles irrespective of their Mw.
Self-Healing Hydrogels: Development, Biomedical Applications, and Challenges
Authors: Rumon Md. Mahamudul Hasan , Akib Anwarul Azim , Sultana Fahmida , Moniruzzaman Md. , Niloy Mahruba Sultana , Shakil Md Salman , Roy Chanchal Kumar
Published: October 2022

Polymeric hydrogels have drawn considerable attention as a biomedical material for their unique mechanical and chemical properties, which are very similar to natural tissues. Among the conventional hydrogel materials, self-healing hydrogels (SHH) are showing their promise in biomedical applications in tissue engineering, wound healing, and drug delivery. Additionally, their responses can be controlled via external stimuli (e.g., pH, temperature, pressure, or radiation). Identifying a suitable combination of viscous and elastic materials, lipophilicity and biocompatibility are crucial challenges in the development of SHH. Furthermore, the trade-off relation between the healing performance and the mechanical toughness also limits their real-time applications. Additionally, short-term and long-term effects of many SHH in the in vivo model are yet to be reported. This review will discuss the mechanism of various SHH, their recent advancements, and their challenges in tissue engineering, wound healing, and drug delivery.
A Node Detection Method Based on Johnson–Cook and Thin-Film IMD Characteristic Model Armor Damage Detection Repair and Subsequent Optimization
Authors: Chang Hanjui , Zhang Guangyi , Sun Yue , Lu Shuzhou
Published: October 2022

In this paper, a node detection method is proposed for the detection of battle damage to armor. This experiment uses the special nature of the film to virtualize the surface of the armor IMD film coverage. The die index is a large area and is easy to damage, but with the use of a unique IMD film stamping die, the possibility of damage decreases, which provides a damage prediction function for the armor. In addition, for the damaged armor, the same method can be used to detect because the damaged part more easily causes the surface film to rupture after being impacted, so it is possible to optimize the design of the armor and the molding through the die index. The die index can also detect the degree of damage to the damaged part of the damaged armor. Therefore, the IMD die index is introduced to quantify the data, and the degree of damage is judged by the IMD die index. The novelty of this work is that each node can efficiently detect the vulnerable damage position of the armor using the die index and then pass through the COMSOL. The Johnson–Cook stress model simulates the battle loss, obtains the stress deformation that occurs after the battle loss, and verifies the experiment by comparing the results obtained. Finally, the repair method is used to repair all the predicted battle damage parts based on additive manufacturing to ensure that they can be used again after repair.
Impact of Sunflower Press Cake and Its Modification with Liquid Glass on Polyurethane Foam Composites: Thermal Stability, Ignitability, and Fire Resistance
Authors: Kairytė Agnė , Członka Sylwia , Šeputytė-Jucikė Jurga , Vėjelis Sigitas
Published: October 2022

Polyurethane (PUR) foams are some of the most promising thermal insulating materials because of their high flammability, but further applications are limited. Therefore, the development of flame-retardant materials with sufficient strength characteristics, water resistance, and low thermal insulating properties is of great importance to the modern building industry. This study evaluates the possibility of a vacuum-based liquid glass (LG) infusion into bio-based fillers, in this case, sunflower press cake (SFP) particles, to improve the mechanical performance, water absorption, thermal insulation, ignitability, thermal stability, and flame retardancy of the resulting polyurethane (PUR) foam composites. The main findings show that LG slightly improves the thermal stability and highly contributes to the ignitability and flame retardancy of the resulting products. Most importantly, from 10 wt.% to 30 wt.%, the SFP/LG filler reduces the thermal conductivity and water absorption values by up to 20% and 50%, respectively, and increases the compressive strength by up to 110%. The results obtained indicate that the proposed SFP/LG filler-modified PUR foam composites are suitable for applications as thermal insulation materials in building structures.
Innovation and Dynamic Productivity Growth in the Indonesian Food and Beverage Industry
Authors: Setiawan Maman , Effendi Nury , Indiastuti Rina , Fahmi Mohamad , Budiono Budiono
Published: October 2022

This paper examines the relationship between innovation and dynamic productivity growth in the Indonesian food and beverage industry. Dynamic productivity growth is calculated using a Luenberger indicator, and innovation is represented by a process innovation. This research uses firm-level data for the period 1980–2015 sourced from the Indonesian Central Bureau of Statistics. This research uses a panel data regression model to estimate the relationship between innovation and dynamic productivity growth. This research finds that innovation is relatively low in the Indonesian food and beverage industry. Dynamic productivity growth declines steadily during the period of estimation. This research also found that innovation positively affected dynamic productivity growth only after the introduction of the competition law in Indonesia.
Design of a Novel Compact MICS Band PIFA Antenna for Implantable Biotelemetry Applications
Authors: Huang Ziyang , Wu Hao , Mahmoud Seedahmed S. , Fang Qiang
Published: October 2022

An implantable stacked planar inverted-F antenna (PIFA) for biotelemetric communication in the 402–405 MHz Medical Implant Communications Service (MICS) frequency band is designed and fabricated. With the proposed PIFA structure, a slot on each radiating patch was embedded, resulting in a size reduction of 0.013 λ and a compact size of 10 × 10 × 1.905 mm3. Both in vitro and in vivo experiments verified the simulation performance with characteristics of −10 dB bandwidth of 29 MHz, radiation efficiency of 0.9%, and a maximum far-field gain of −18.8 dB. We calculated the safety power delivered to the antenna using the specific absorption rate (SAR) limitation standard. Compared to other implantable antennas for biotelemetry, this antenna performs comparably and has a smaller size. This design would further develop implantable medical devices that communicate in the MICS band.
Pricing Decisions with Effect of Advertisement and Greening Efforts for a Greengocer
Authors: Shah Nita , Shah Pratik , Patel Milan
Published: October 2022

Organic farming has become popular and in demand among health-conscious people nowadays. Organic vegetables are grown using organic seeds and natural fertilizers. People have turned to using organic food products not only due to them being fresh and full of nutrition but also being eco-friendly. The present study is carried out to outline pricing decisions for a greengrocer of organic products. The grocer grows and sells fresh vegetables with the input of greening efforts. The grocer uses advertisements to promote sales. Product demand is influenced by the selling price of the product, greening efforts, and advertising efforts. The problem is formulated into a mathematical model to obtain optimum policies to maximize the total profit of the greengrocer. The model is validated by an illustration. The impact of small-scale changes in inventory parameters on decision variables is studied to analyze managerial aspects. The results show that the sales volume increases due to advertisements and greening efforts up to a certain level. Once the peak sales level is achieved, such investments are of no use, and they cause a drop in overall profit. The selling price of the product can be reduced in the absence of advertisement efforts, but, eventually, it causes a fall in the sales volume.
Profound Impact of Economic Openness and Digital Economy towards a Sustainable Development: A New Look at RCEP Economies
Authors: Wang Feilan , Jin Mengmeng , Li Jianfeng , Zhang Yushuo , Chen Junbo
Published: October 2022

Sustainable development has become a serious challenge for the globe. Therefore, globalization and the digital economy are considered crucial factors for sustainable development (SD). The current study tries to estimate the link between trade openness and information and communication technology (ICT) with sustainable growth via a linear function in which economic growth, urbanization, and human capital are taken as independent variables. The study employs the Interactive Fixed Effect (IFE) and Dynamic Common Correlated Effect (D-CCE) to quantify the long-term association among variables in a multiplicative framework. The obtained outcomes show a significant contribution of globalization and the digital economy to sustainable growth. Likewise, economic growth and human capital cause a decline in sustainable growth. Moreover, the empirical outcomes show the discouraging role of urbanization in sustainable development. Additionally, a bi-directional association exists between sustainable development and trade openness and economic growth, trade openness and economic growth, urbanization and human capital, and economic growth and urbanization. Such findings further strengthen policymakers’ belief in other nations to promote sustainable development. Moreover, to alleviate the economic growth losses, we suggest setting up a sustainable development sharing mechanism among regions.
Malaysian Parents’ Willingness to Vaccinate Their Children against COVID-19 Infection and Their Perception of mRNA COVID-19 Vaccines
Authors: Wong Li-Ping , Lee Hai-Yen , Alias Haridah , AbuBakar Sazaly
Published: October 2022

Little was known about Malaysian parental attitudes, beliefs, and intentions surrounding coronavirus disease 2019 (COVID-19) vaccines for children when the National COVID-19 Immunization Program for Children (PICKids) was launched in February 2021. A cross-sectional online survey-based study was carried out from 15 March 2022 to 23 July 2022 on Malaysian parents/guardians of children between ages 5 and below 12 years old. A total of 15.7% reported being extremely willing, and 38.9% were somewhat willing to vaccinate children with a COVID-19 vaccine. Perceived low susceptibility to COVID-19 infection showed the greatest significant impact on vaccine acceptance (OR 35.46, 95% CI 15.26–82.40). Parents with a lower level of concern have a higher willingness for vaccination (OR 1.25, 95% CI 0.90–1.75). Of the parents that knew of the mRNA vaccine, 46.6% reported that they prefer their children to be vaccinated with conventional vaccines over mRNA vaccines. Poor knowledge about mRNA vaccines, lack of confidence in the mRNA technology, fear of unknown side effects, and perception that the mRNA vaccines contain microchips were significantly associated with a higher level of concern about their children receiving an mRNA vaccine. Public education campaigns to promote COVID-19 vaccination for children warrant addressing the concerns and knowledge deficits among vaccine-hesitant parents.
Teaching Floods in the Context of Climate Change with the Use of Official Cartographic Viewers (Spain)
Authors: Olcina Jorge , Morote Álvaro-Francisco , Hernández María
Published: October 2022

Floods are the natural hazard that have the greatest economic impact and cause the most deaths in the Mediterranean region. The objective of this study is to present different proposals for teach the risk of flooding using the GIS viewers offered by the NFZMS (National Flood Zone Mapping System) and the PATRICOVA (Spain). The idea is that, based on the selection of the same area of study (the mouth of the Júcar River—Valencia—and the mouth of the Segura River—Alicante), students determine the similarities and differences, for educational purposes, of these two geographical viewers. These proposals are aimed at the 2nd year of the Baccalaureate (17–18 years; optional subject of Geography). The objective is to enhance the skills of the students for understand the territory, especially their immediate environment, in the learning process. Furthermore, it also seeks to expand the knowledge of students with regard to these extreme phenomena experienced by society. This proposal shows that these types of tools are important for students to understand the social and territorial part of flooding events (vulnerability and exposure), which is the most salient part in terms of finding solutions to minimise their effects.
Anthropogenic Influences on the Hydrochemical Characteristics of the Groundwater in Xiamen City, China and Their Evolution
Authors: Li Zhenghong , Li Jianfeng , Zhu Yuchen , Li Yasong , Hao Qichen
Published: October 2022

This study analyzed the anthropogenic influences on the hydrochemical composition characteristics of the groundwater in Xiamen City, Fujian province, China, and their evolution. Based on the hydrochemical data of the groundwater of 1993 and 2019–2021, this study identified the indices of the anthropogenic influences using mathematical and statistical analysis methods, such as contrast coefficient, standard deviation, and Mahalanobis distance. The analytical results are summarized as follows: (1) the number of the indices affecting the groundwater quality in Xiamen increased from nine in 1993 to 15 in 2019, and the six increased indicators included NO3−, Pb, NH4+, Al3+, NO2− and Cu (the contribution rates to poor-quality were 26.0%, 16.3%, 10.6%, 4.1%, 0.8% and 0.8%, respectively) which were related to the input of human activities. During this period, the number of hydrochemical types increased from 19 in 1993 to 28 in 2019, with a decrease in the water of the HCO3 type and an increase in the water of Cl and SO4 types; (2) In 2019, NO3− had higher content than SO42− in the groundwater and became a major anion, forming the water of NO3 type; (2) as indicated by the analytical results obtained using the Mahalanobis distance method, areas with strong anthropogenic influences include densely populated areas and areas with intensively distributed industrial enterprises, while anthropogenic influences are very weak in the northern forest land area.
Establishing a Data Fusion Water Resources Risk Map Based on Aggregating Drinking Water Quality and Human Health Risk Indices
Authors: Nadiri Ata Allah , Sedghi Zahra , Barzegar Rahim , Nikoo Mohammad Reza
Published: October 2022

The Drinking Water Quality Index (DWQI) and the Human Health Risk Index (HHRI) are two of the most promising tools for assessing the health impact of water quality on humans. Each of these indices has its own ability to determine a specific level of safety for drinking, and their results may vary. This study aims to develop an aggregated index to identify vulnerable areas in relation to safe drinking water and, subsequently, risk areas for human health, particularly non-cancerous diseases, in the Maku–Bazargan–Poldasht area in NW Iran through the use of a data fusion technique. Nitrate (NO3−) and fluoride (F−) are the predominant contaminants that threaten the local population’s health. The DWQI revealed that the majority of the study sites had poor to improper quality for drinking water class. Health risk assessments showed an excessive potential for non-carcinogenic health risks because of high NO3− and F− exposure through drinking water. Children are at a higher risk for non-carcinogenic changes than adults, according to the total hazard index (THI; NO3− and F−), suggesting that locals have faced a lifetime risk of non-cancer changes as a consequence of their exposure to these pollutants. Using data fusion techniques can assist in developing a comprehensive water resources risk map for decision-making.
Can Taurine Supplementation in a Diet with Soybean Meal Instead of Fish Meal Improve the Growth Performance, Feed Utilization, and Antioxidant Capacity of Spotted Knifejaw (Oplegnathus punctatus)?
Authors: Wu Duoting , Xu Hanying , Yang Yunxia , Feng Wenping , Han Tao , Wang Jiteng
Published: October 2022

To determine the impact of replacing fish meal (FM) in the diet with various levels of soybean meal (SBM) on the spotted knifejaw Oplegnathus punctatus, a 56 day feeding trial was done. Seven diets were formulated with SBM to replace 0% (SBM0), 30% (SBM30), 40% (SBM40), 50% (SBM50), 60% (SBM60), and 70% (SBM70) of FM protein, and SBM50 + T was developed on the basis of SBM50 with the addition of 1.2% taurine. There were triplicate groups of 18 fish (initial weight: 14.62 ± 0.02 g). The weight gain (WG), specific growth rate (SGR), feed efficiency (FE), and protein efficiency ratio (PER) values of the SBM0, SBM30, and SBM50 + T groups were found to be significantly higher than those of the SBM60 and SBM70 groups (p < 0.05). The daily energy gain (DEG), daily nitrogen gain (DNG), daily lipid gain (DLG), energy retention (ER), nitrogen retention (NR), and lipid retention (LR) values decreased significantly with increasing dietary SBM levels (p < 0.05). The highest retention of most amino acids (except lysine) was observed in the SBM30 group (p < 0.05). The lipid content of the whole body and dorsal muscle decreased significantly as dietary SBM levels increased (p < 0.05). Fish fed the SBM70 diet had the lowest serum triglyceride (TG) concentrations (p < 0.05). The effects of different treatments on total cholesterol (T-CHO) were not significant (p > 0.05). Fish fed the SBM0 and SBM30 diets had the highest amylase (AMS) and lipase (LPS) activities (p < 0.05). The lowest liver superoxide dismutase (SOD) and catalase (CAT) activities were observed in the SBM70 group. The malondialdehyde (MDA) concentration of the SBM50 to SBM70 groups were significantly higher than that of other groups (p < 0.05). The levels of interleukin 8 (il-8) mRNA were highest in fish fed the SBM0, SBM30, and SBM50 + T diets (p < 0.05), while the level of transforming growth factor β1 (tgf-β1) was the opposite (p < 0.05). According to the broken line regression of WG and FE, the highest level of FM substitution by SBM for Oplegnathus punctatus was 24.07–25.31%.
Sugarcane Bagasse and Orange Peels as Low-Cost Biosorbents for the Removal of Lead Ions from Contaminated Water Samples
Authors: Molaudzi Ntsieni Romani , Ambushe Abayneh Ataro
Published: October 2022

The pollution of water by lead (Pb(II)) constitutes a substantial threat to the environment and subsequently to animals and humans. In this study, the efficacy of sugarcane bagasse (SCB) and orange peels (OPS) have been investigated as potential low-cost biosorbents, individually and in a homogeneous combination for the removal of Pb(II) from simulated and real water samples. Biosorbents were characterised using Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), scanning electron microscopy (SEM) coupled to energy-dispersive X-ray spectroscopy (EDS), transmission electron microscopy (TEM), powder X-ray diffraction (pXRD), a zeta potential analyser, and the Brunauer–Emmett–Teller (BET) method. Batch adsorption studies were explored under several experimental conditions to optimise the removal efficiency of Pb(II) ions from artificially contaminated aqueous solutions. The pH study revealed optimum removal efficiencies of Pb(II) at pH 7, for SCB and OPS. The optimum contact time for SCB and OPS individually and a homogenous mixture was 60, 120, and 120 min, respectively. The study also revealed that the optimum biosorbent dosage was 0.2, 0.17, and 0.2 g for SCB, OPS, and the homogenous combination of SCB and OPS (1:1). Optimum experimental conditions could achieve up to 100% removal efficiencies for 10 and 20 mg/L of Pb(II) using SCB and OPS, respectively. The potential of the homogenised combination of biosorbents demonstrated 100% removal efficiencies for 10 mg/L of Pb(II). The removal of 10 mg/L of Pb(II) in real water samples remained at 100% for biosorbents individually and the homogenised combination. The reusability performance of SCB, OPS, and the homogenised combination of SCB and OPS presented Pb(II) removal efficiencies above 70% for three adsorption–desorption cycles.
Ocean Remote Sensing Techniques and Applications: A Review (Part I)
Authors: Amani Meisam , Moghimi Armin , Mirmazloumi S. Mohammad , Ranjgar Babak , Ghorbanian Arsalan , Ojaghi Saeid , Ebrahimy Hamid , Naboureh Amin , Nazari Mohsen Eslami , Mahdavi Sahel , Moghaddam Sayyed Hamed Alizadeh , Asiyabi Reza Mohammadi , Ahmadi Seyed Ali , Mehravar Soroosh , Mohseni Farzane , Jin Shuanggen
Published: October 2022

Oceans cover over 70% of the Earth’s surface and provide numerous services to humans and the environment. Therefore, it is crucial to monitor these valuable assets using advanced technologies. In this regard, Remote Sensing (RS) provides a great opportunity to study different oceanographic parameters using archived consistent multitemporal datasets in a cost-efficient approach. So far, various types of RS techniques have been developed and utilized for different oceanographic applications. In this study, 15 applications of RS in the ocean using different RS techniques and systems are comprehensively reviewed and discussed. This study is divided into two parts to supply more detailed information about each application. The first part briefly discusses 12 different RS systems that are often employed for ocean studies. Then, six applications of these systems in the ocean, including Ocean Surface Wind (OSW), Ocean Surface Current (OSC), Ocean Wave Height (OWH), Sea Level (SL), Ocean Tide (OT), and Ship Detection (SD), are provided. For each application, the applicable RS systems, their advantages and disadvantages, various RS and Machine Learning (ML) techniques, and several case studies are discussed. The other nine applications, including Iceberg, Sea Ice (SI), Sea Surface temperature (SST), Ocean Surface Salinity (OSS), Ocean Color (OC), Ocean Chlorophyll (OCh), Ocean Oil Spill (OOS), Underwater Ocean, and Fishery, are provided in Part II of this study.
FARMACÊUTICO ONCOLÓGICO NO SUS
Authors: Nepomuceno Caio Maia , Morbeck Natália Belo Moreira , Lobo Márcia Germana Alves de Araújo , Panontin Juliane Farinelli
Published: October 2022

O Sistema Único de Saúde rede de atendimento público de saúde presente no Brasil, no qual, tem consigo diferentes níveis de atendimentos a população. Onde, a oncologia é agregada em sua rede de atenção como especialidades ofertadas de forma que consagra os princípios do SUS. A assistência oncológica é realizada em diversos níveis no qual inclui a média e alta complexidades, tendo como o farmacêutico responsável por diversas atribuições, excedendo a simples dispensação da prescrição médica. Este presente trabalho tem como objetivos informativos e exploratório frente às diferentes unidades de atendimentos oncológicos, inclusão de tratamentos antineoplásicos na rede pública e as diferentes atribuições do profissional farmacêutico. Tendo como metodologia revisão de literatura utilizando como fonte o Google Acadêmico, Legislação Brasileira e documentos do Ministério da Saúde. Por fim, é notório que o SUS abrange os diferentes níveis de atendimentos a população com tratamentos específicos aos diferentes tipos de cânceres e com isso o farmacêutico é disposto para realização de manipulação, solicitação de compras de medicamentos e materiais essenciais e produção de protocolos clínicos e administrativos para as unidades oncológicas.
EFICÁCIA DA VENTILAÇÃO NÃO INVASIVA NA REDUÇÃO DA TAXA DE INTUBAÇÃO OROTRAQUEAL EM INDIVIDUOS COM COVID-19
Authors: Marin Luciana Fernandes Maia , Araújo Gabriela Martins , Nunes Rosângela Dos Reis
Published: October 2022

Covid-19 é uma doença respiratória causada por um novo tipo de coronavírus, o SARS-Cov-2. Os coronavírus são uma grande família de vírus que causam doenças respiratórias que variam em gravidade, desde um resfriado comum até pneumonia fatal. A ventilação mecânica não invasiva (VNI) consiste na aplicação da ventilação artificial sem a necessidade da utilização de próteses endotraqueais. Essa ventilação é ofertada por intermédio de máscaras especiais, via oral ou nasal. Este estudo teve por objetivo verificar se a utilização da VNI é eficaz na redução da taxa de intubação orotraqueal em pacientes com Covid-19. Para tanto, foi realizado um levantamento e uma análise da literatura relativa ao período de 2013 a 2022. Este estudo identificou que a VNI pode ser um método eficaz para evitar ou retardar a intubação orotraqueal em pacientes infectados com Covid-19. No entanto, é necessário que haja um bom acompanhamento do quadro do paciente e extrema atenção da equipe médica aos sinais, sintomas e necessidades clínicas para que não se subestime a necessidade de intubação orotraqueal.
Experience in using virus-neutralizing monoclonal antibodies in the treatment of Covid-19
Authors:   SBHI Aleksandro-Mariinsky Regional Clinical Hospital, Astrakhan, Buzina O.R. , Kuleshevskaya N.R. ,   SBHI Aleksandro-Mariinsky Regional Clinical Hospital, Astrakhan, Evteeva A.S. ,   SBHI Aleksandro-Mariinsky Regional Clinical Hospital, Astrakhan, Alieva A.R. ,   SBHI Aleksandro-Mariinsky Regional Clinical Hospital, Astrakhan
Published: October 2022

The authors conducted a retrospective analysis of the efficacy and safety of virus-neutralizing monoclonal antibodies in the treatment of COVID-19.
Biochemical aspects of gout pharmacotherapy with colchicine and allopurinol
Authors:   FSAEI HE Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Vlasova A.A.
Published: October 2022

Gout is translated from Greek as “like a foot-trap”, and this disease is also known as the “disease of the aristocrats”. Gout has been known to mankind since ancient times; the first written mention of gout was found in ancient Egypt, then this topic was raised more than once in the works of such pillars of medicine as Hippocrates, Celsus, and Galen. This problem remains relevant in the modern world as well. Most often, men over 40 years of age suffer from this disease, but there is currently an increase in the incidence of gout, including in women and young people. So, what is gout? Gout is a chronic polyetiological disease associated with a purine metabolism disorder, characterize by an increase in the level of uric acid in the blood (hyperuricemia) and the deposition of the sodium salt of uric acid (urate) in the joints, periarticular tissues and internal organs with the development of recurrent arthritis and the formation of gouty nodules (tophi). The aim of our research was to study the features of gout pharmacotherapy. To achieve it, the following tasks were set and fulfilled: the mechanism of development of gout as a hereditary polyetiological disease was considered, and the biochemical aspects of the formation and course of the disease were highlighted. Treatment is prescribed depending on the period of the disease, including drugs for stopping an attack (NSAIDs, colchicine, corticosteroids and monoclonal antibodies) and maintenance therapy in the interictal period (allopurinol and uricosuric drugs). In the course of the work, we were interested in the mechanisms of action of drugs such as allopurinol and colchicine, therefore, these were given special attention.
Multi-format marketplaces as a driver of e-commerce development in Russia
Authors:   Plekhanov Russian University of Economics, Moscow, Krasilnikova E. A.
Published: October 2022

Forecasted in 2022, the e-commerce turnover in the Russian Federation will amount to 4,207 billion rubles which is 16 % higher than in 2021. Significant annual growth forms a steady trend of e-commerce achieving the third of total retail turnover in the country, which predetermines detailed estimates of this segment, factor analysis, and the determination of drivers of development.
Change of the «Sad» cafe concept in the shopping and entertainment center «Grad» City-Park
Authors:   Department of Tourism and Hospitality, Voronezh State University of Engineering Technologies, Glagoleva L. E. , Zatsepilina N. P. ,   Department of Tourism and Hospitality, Voronezh State University of Engineering Technologies, Kovaleva E. N. ,   Department of Tourism and Hospitality, Voronezh State University of Engineering Technologies, Sekhniev M. E. ,   Voronezh State University of Engineering Technologies
Published: October 2022

The article discusses the marketing approach and, on its basis, a new concept for organizing the work of a cafe. The approach under consideration is based on information technologies used in the field of hospitality in public catering, uniting the activities of all restaurant services. The use of a relational database makes the system integrated with the technological platform «1C: Enterprise» version 8.2.
PSYCHOLOGICAL PORTRAIT OF A SERIAL KILLER IN THE INTRASUBJECTIVE PERCEPTION OF THE ORDINARY CITIZEN
Authors: Katolyk H. , Binnebesel J.
Published: October 2022

The topic of serial killers is incredibly relevant today, because these people appear everywhere and spread fear and death. Today it is unknown exactly who they are and how many lives have already been taken, and how many more will be taken… The exact number of victims, of some already caught and punished killers, is unknown. The difficulty is also in "hunting" for such people: until a pedantic and attentive maniac makes a mistake, it is difficult to catch him, because he is competent in how to plan the murder, so as not to leave evidence. Unfortunately, investigators, psychiatrists and psychologists still often misunderstand the thinking of such individuals, which directly affects the quality of the investigation process. Ukraine, as a democratic state, recognizes people, their life and health, honor and dignity, inviolability and security as its top priorities. In fact, this is the greatest social value. Everyone has the inalienable right to life. It is the legal protection of a person from criminal encroachments on life and health, as the most important social values, that the state should provide through its law enforcement agencies. We are in a state of prolonged military intervention amid an even longer pandemic with ever-increasing threats of social instability and existential personal and social crisis. All these factors increase the general state of increasing social aggression, which in turn can stimulate and stimulate (as recent events in Bucha and other places of hostilities show) people who are on the verge of pathological aggression to active action.

Therefore, the chosen topic of our research, namely "Psychological portrait of a serial killer in the intrasubjective perception of the average citizen" may reveal new aspects of this problem.
Studies on the Psychrotrophic Bacteria from Croaker Fish (Johnius dussumieri) Treated with Propyl Paraben
Authors: SINGH KARTAR
Published: October 2022

Psychrotrophs belonging to the genera Flavobacterium, Pseudomonas, Vibrio, Achromobacter, Pseudobacterium and Micrococcus were isolated from croaker fish (Johnius dussumieri) treated with preservative, propyl p-hydroxy 4-benzoate (paraben). The optimum growth temperature for the selected cultures was 27±2°C and visible growth was discernable at O"C within 8-10 days. A generic succession was observed as the spoilage of fish advanced. Pseudomonas, Achromobacter and Vibrio dominated over other genera as late spoilers. Biochemical activities of these genera were also tested.
Effect of Aeration on Mineralization of Organic Nitrogen in Brackishwater Fishpond Soil
Authors: MOHANTY A.N.
Published: October 2022

The mineralization of organic nitrogen at different salinity levels of brackishwater fishpond soils upon addition of cowdung was studied under laboratory conditions at ambient temperature 28.8-30.G•c over 120 days. Upon aeration, percent-. age gains in mineralized nitrogen at 0.5, 10, 20 and 30 ppt. Salinity ranged between 26.1 and 28.5% and were not significantly different. However, the rate of mineraliza­tion was slower at higher salinities.
Discovery of a Myxosporidean With Four Valves in a Freshwater Fish and Discussion of Its Taxonomic Position
Authors: SHING-REN HSIEH , CHONGXUE XIAO
Published: October 2022

A new myxosporidean, Octospina tongrensis n.g., n.sp. is described from the swimbladder wall and gallbladder of a grass carp (Ctenophoryngodon idella) collected in May 1988 in Tongren District, Guizhou Province, China. The spore is oval in frontal view with four similar shell valves of elongate oval form. The four sutural ridges are fine and distinct, extending anteriorly and posteriorly in the form of eight spines. Four equal pyriform. polar capsules are present in the anterior part of the spore; a large iodinophilous vacuole is present in the sporoplasm. A new family Spinavaculidae n. fam., is created to contain the new genus Octospina. The new family clearly does not fit within either of the two myxosporean orders as they are cunently defined, i.e., Bivalvulida and Multivalvukida. We suggest that it be defined as "incertae sedis."
Hematological Responses of the Common Carp, Cyprinus carpio L. Exposed to the Pesticide Endosulfan
Authors: CHANDRASEKAR S. , JAYABALAN N.
Published: October 2022

Common carp, Cyprinus carpio L., were exposed to 5%, 10% and 15% concentrations of the 96·hour LC50 value of endosulfan for 7, 14 and 21 days. The fish re­sponded with significant decrease in the levels of hemoglobin and hematocrit. While little variation in the serum protein was noticed, a significant elevation of blood glu­cose level indicated a hyperglycemic condition in the treat.eel fish. The levels of sodium and potassium of fish blood were lower than those in the controls. However, only the decrease of potassium. in relation to exposure periods (7 and 21 days) was significant.
Perancangan Sistem Informasi Aset Perusahaan Pada CV di Bidang Properti
Authors: Santiari Ni Putu Linda , Rahayuda I Gede Surya
Published: October 2022

Perusahaan XYZ merupakan perusahaan yang bergerak di bidang properti. Pengolahan data persediaan yang diterapkan pada perusahaan ini masih bersifat manual. Diantaranya pencatatan dan pengelolaan data persediaan yang dibedakan dengan divisi yang masih menggunakan aplikasi pengolah angka berupa Microsoft Excel yang menghasilkan output berupa file yang kurang terstruktur dan menyulitkan pencarian data jika jumlahnya besar. Hal yang biasa terjadi jika pengolahan data menggunakan Microsoft Excel adalah dapat terjadi duplikasi data, baik yang disengaja maupun tidak disengaja. Selain duplikasi data, penggunaan Microsoft Excel menyulitkan pengguna lain untuk mengakses atau mencari data tertentu untuk diproses karena file hanya tersedia untuk satu pengguna. Dari permasalahan pengelolaan data aset yang kurang, maka perlu dirancang suatu sistem informasi pengelolaan data aset pada perusahaan XYZ. Perancangan dilakukan dengan melakukan analisis kebutuhan yang dilanjutkan dengan perancangan sistem. Hasil analisis kebutuhan pengguna, terdapat tiga pengguna aset sistem informasi yaitu admin, supervisor, dan staff. Perancangan didasarkan pada analisis kebutuhan pengguna dengan merancang Data Flow Diagram (DFD) dan Entity Relationship Diagram (ERD), perancangan database, dan perancangan antarmuka sistem informasi yang akan dibangun berbasis website. Perancangan antarmuka meliputi perancangan antarmuka halaman utama, perancangan antarmuka halaman admin, perancangan antarmuka supervisor, perancangan antarmuka halaman staff, perancangan halaman tambah asset keluar, perancangan antarmuka halaman asset masuk, antarmuka halaman inventaris masuk dan keluar, antarmuka halaman tambah user. Dengan perancangan ini, perusahaan memiliki gambaran sistem informasi yang akan dibangun dan menyesuaikan dengan kebutuhan.