bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH POC KULIT PISANG KEPOK DAN PUPUK TSP TERHADAP PERTUMBUHAN DAN HASIL TANAMAN KACANG TANAH (Arachis hypogeae L.)
Authors: Rudianto  , T. Edy Sabli  , Raisa Baharuddin
Published: January 2023

Kepok banana is quite widely used in Pekanbaru because this banana is one of the main ingredients in making typical Riau Pekanbaru food souvenirs. Therefore, the waste of banana peel produced is very high. If left unchecked, it will have a negative impact on the surrounding environment. Based on this, the solution may be processing banana peels as LOF (Liquid Organic Fertilizer).  The purpose of this study was to determine the effect of liquid organic fertilizer from kepok banana peels and TSP on the growth and production of peanut plants. This study used a factorial completely randomized design (CRD) with 3 replications. The first factor was the concentration of LOF kepok banana peels, consisting of 4 levels, 10, 20, and 30 ml/l of water, and the second factor was the dose of TSP fertilizer, consisting of 4 levels, are 0, 6, 12, and 18 g/plot. The parameters observed were plant height, appropriate growth rate, net assimilation rate, pod dry weight per plant, the weight of 100 seeds, and harvest index. The data were analyzed by ANOVA with the BNJ further tested at the 5% level. The results showed that the interaction of kepok banana peel POC treatment and TSP significantly affected all parameters and increased the growth and production of peanuts. The results with the best treatment combination were 30 ml/l of POC Kepok banana peels concentration and  18 g/plot of TSP dose.
UJI BEBERAPA KONSENTRASI TEPUNG DAUN BABADOTAN (Ageratum conyzoides L.) UNTUK MENGENDALIKAN HAMA KUMBANG BIJI KACANG HIJAU (Callosobruchus chinensis L.) DI PENYIMPANAN
Authors: Adhytia Ika Pramesty  , Desita Salbiah
Published: January 2023

Callosobruchus chinensis L. is a pest that can damage and reduce the quality of mung bean seeds in storage. Pest control can be done using botanical insecticide babadotan plants (Ageratum conyzoidez L.). This research aims to obtain an effective concentration of babadotan leaf flour against C. chinensis in storage. The research was conducted at the Plant Pest Laboratory, Faculty of Agriculture, University of Riau. The research used a completely randomized design (CRD) with six treatments and four replications. The treatments were given several concentrations of babadotan leaf flour 5 g.100 g-1, 6 g.100 g-1, 7 g.100 g-1, 8 g.100 g-1, 9 g.100 g-1 dan 10 g.100 g-1 mung bean seeds. The parameters observed were an initial time of death, Lethal time 50, daily mortality, total mortality, individual increase, and weight loss of seeds. The results showed that the concentration of babadotan leaf flour 9 g.100 g-1 mung bean seeds was effective to control C. chinensis because it could cause total mortality at 87.50% with an initial time of death of 7.50 hours after application and Lethal time of 50 of 33.75 hours after application and resulted in an increase of 5.50 individuals and was lead to a weight loss percentage of mung beans seeds by 0,70%.
UJI BEBERAPA KONSENTRASI EKSTRAK TEPUNG DAUN PAITAN (Tithonia diversifolia A. Gray) TERHADAP MORTALITAS LARVA PENGGEREK TONGKOL JAGUNG Helicoverpa armigera Hubner
Authors: Sandi Syahputra  , Rusli Rustam  , Desita Salbiah
Published: January 2023

Borer pest of corn cobs (Helicovepa armigera Hubner) is a major pest of corn. Pest control can be done using plant-based insecticides from paitan leaf extract (Tithonia diversifolia A. Gray). This study aims to obtain the best concentration of paitan leaf extract in controlling corn cob borer Helicoverpa armigera. The study was conducted at the Plant Pest Laboratory of the Faculty of Agriculture, University of Riau. The research was carried out using a completely randomized design (CRD), consisting of 5 treatments and 4 replications. The treatments used were several concentrations of paitan leaf extract, namely 0 gl-1, 25 gl-1, 50 gl-1, 75 gl-1and 100 gl-1. Parameters observed were initial death, lethal time 50, lethal concentration (LC50 and LC95), daily mortality, and total mortality. data. Data were collected from daily mortality and then descriptively analyzed and displayed graphically. Data lethal concentration (LC50 and LC95) were analyzed probit using the POLO-PC program, while other data such as initial death, total mortality, and lethal time (LT50) were analyzed with analysis of variance. Data from the variance analysis with significant effect will be continued using the smallest significant difference (LSD) test at the 5% level. Results showed that the application of paitan leaf extract with a concentration of 100 gl-1 water was able to control H. armigera with mortality of 55.00%. The proper concentration to lead mortality of 50% of larvae H. armigera was 10.3% or equal to 103 gl-1 of water of paitan leaf extract. Meanwhile, the proper concentration to lead mortality of 95% of larvae population H. armigera was 44.7% or equivalent to 447 gl-1 water of paitan leaf extract.
STRUKTUR BIAYA USAHA BUDIDAYA LEBAH MADU DI DESA KUAPAN KECAMATAN TAMBANG KABUPATEN KAMPAR (Kasus Usaha Madu “Mekar Sari”)
Authors: Ilma Satriana Dewi
Published: January 2023

Communities in the Riau area have started cultivating honey bees both traditionally and in a modern way. However, the development of honey bee farming (Apis cerana) is currently still not progressing even though the business has been running for quite a long time. This could have been caused by several things, namely poor business management, starting from cultivation activities to quite high production costs. This study aims to analyze breeder characteristics and profiles, analyze production costs, production, income, and business efficiency, and analyze the cost structure of the "Mekar Sari" honey bee business. This research was conducted using a survey method, namely in the honey bee (Apis cerana) cultivation business in Kuapan Village, Tambang District, Kampar Regency. The analytical method used in this study is descriptive qualitative and quantitative analysis. The results showed that the breeders made the honey bee business a side business. The farmer is 30 years old and belongs to the productive age, his last education is a Bachelor of Animal Husbandry (S1), 10 years of farming experience, and has 3 dependents (1 wife and 2 children). The profile of the honey bee business "Mekar Sari" started as a group business funded by government assistance, but many members withdrew so the number of honey beekeepers decreased. Only 1 member of the group survives and continues the "Mekar Sari" honey business to this day. The production cost used in the "Mekar Sari" honey business is IDR 77,123,362/year, with a production of 800 kg. Gross income of IDR 120,000,000/year, and net income of IDR 42,876,638/year, and an efficiency of 1.55. The cost structure of the honey bee business "Mekar Sari" consists of the cost of production facilities with a percentage of 91.74%, labor costs of 2.77%, and equipment depreciation costs of 5.44%.
Rainfall Precipitation Pattern from 2001-2021 over Andhra Pradesh Region in India
Authors: Prasad B. , Brahmaji Rao P. , Ramamohanarao P. , Sarathkumar S.
Published: January 2023

The research focuses on a key meteorological variable, precipitation, in order to analyze the changing trend of rainfall in Andhra Pradesh, India. The State highly depends on rainfall for its agricultural activities, but the occurrence of rainfall is unprecedent and variable, causing adverse implications on the cropping system as well as negative effects on natural water resources. Daily data from the years 2001 to 2021 were analyzed to determine monthly, seasonal and yearly rainfall variability using statistical methods such as mean, standard deviation (SD) and coefficient variability (CV). District wise monthly, seasonal and annual rainfall trends have been drawn using 21-year daily data. The statistical analysis of whole reference time series data reveals that maximum mean South West Monsoon (SWM) rainfall is received in the north and central coastal districts of Srikakulam, Visakhapatnam, Vizianagaram, East Godavari, West Godavari and Krishna. North East Monsoon (NEM) rainfall contributes significantly in mean annual rainfall of southern coastal district and Rayalaseema sub division of the State.
Youth Participation and Disaster: Examining Suggestions on Disaster Risk Reduction Management in Metro Manila, Philippines
Authors: Ancheta Jeffrey Rosario
Published: January 2023

Communication is critical in all areas of disaster risk reduction management (DRRM). Efficient and comprehensive information is essential to minimize unanticipated and unexpected economic and social repercussions and increase the response's effectiveness. Furthermore, the local government unit should discuss youth involvement in DRRM to develop inclusive policies. Thus, this study examines 752 typhoon-and-flood-related textual suggestions of youth leaders and volunteers from different typhoon and flood communities in Metro Manila, Philippines to discuss emerging themes on DRRM. Using Google Forms, this study gathers suggestions regarding the disaster governance measures of the participant's respective communities. Youth leaders' and volunteers' suggestions for better disaster preparedness revealed seven thematic recommendations including the need for more robust early warning systems, information campaigns, capacity building and tactics for increasing personal preparedness. Filipino values such as damayan (to give sympathetic support), pakikipagkapwa (having a sense of shared identity) and bayanihan (a spirit of communal unity) have also emerged from the suggestions. The role of women and persons with disability was also a repeated theme that will empower them in times of disaster. Overall, this study provides initial insight into youths' role in increasing inclusivity in local government and communities' decision-making processes on disaster risk reduction management.
Evaluation of Optimal Ghat Road Alignment integrating Engineering, Environmental and Landslide Parameters using Geospatial Analysis
Authors: Kolanuvada Srinivasa Raju , Kannan Praveenkumar
Published: January 2023

Roads in a hilly region contribute to significant development of the area and may cause negative impacts on the fragile environment. Optimal road alignment in the hilly region is challenging and mandates geospatial analysis that involves topographic and environmental parameters like slope, soil stability, forest cutting and obstruction to drainage. In this study, a multi-objective approach is proposed to delineate optimal road alignment in the hilly region of Sathuragiri hills, India using Geographic Information System (GIS) based integration techniques. Analytical Hierarchy Process (AHP) was used to generate suitability surfaces based on Engineering, Environmental, Landslide and Hybrid approaches. Thematic information like geology, land use, drainage network, slope, aspect, soil texture, distance from the road etc. have been generated from Remote Sensing and Collateral datasets. The suitability surfaces were generated through standardization and integration of criteria using a weighted overlay approach in the GIS environment. Alternate alignments were generated with these suitability surfaces using Dijkstra Algorithm for finding the shortest cost path. These alignments were evaluated for critical parameters like length of road, no. of bridges/culverts, area of forest cutting, area of agriculture land affected, length of road in critical slopes. The results indicate the efficiency of the hybrid approach combining the engineering, environmental and landslide risk-based parameters in the alignment planning.
Pathogenetic and regenerative features of corneal damage repair with biodegradable materials based on silk fibroin
Authors: М.Б. Агаммедов, , Д.С. Островский, , В.П. Соболев, , Л.И. Ушакова, , И.И. Агапов, , Н.А. Гаврилова, , С.А. Борзенок,
Published: January 2023

На сегодня известно, что биодеградируемые конструкции на основе фиброина шелка могут использоваться в качестве безопасного носителя биологически активных веществ и лекарственных препаратов. При этом последние исследования показали, что глиальный нейротрофический фактор является одним из необходимых факторов роста, участвующих в восстановлении роговичной ткани. Однако не изучен способ восстановления роговичных повреждений при помощи биодеградируемых конструкций на основе фиброина шелка, содержащих глиальный нейротрофический фактор, что объяснило цель данного исследования. Цель: изучить особенности восстановления роговичных повреждений при помощи биодеградируемых конструкций на основе фиброина шелка, содержащих глиальный нейротрофический фактор. Материалы и методы: Исследование проводилось на половозрелых самцах мышей линии C57BL/6. У животных формировали модель повреждения роговицы. В ходе эксперимента у мышей на 1-е, 3-и и 5-е сутки после повреждения проводили анализ площади эпителиального дефекта роговицы для оценки интенсивности регенеративного процесса. Результаты: установлено, что интенсивность регенеративного процесса была выше в группах мышей с применением биодеградируемых конструкций на основе фиброина шелка, содержащих глиальный нейротрофический фактор, по сравнению с контрольной группой. Выводы: Применение биодеградируемых конструкций на основе фиброина шелка, содержащих глиальный нейротрофический фактор, стимулирует процесс восстановления роговичной ткани после моделированного повреждения.

Background: Today it is well known that biodegradable materials based on silk fibroin can be used as safe carriers of biologically active substances and drugs. At the same time, recent studies have shown that glial neurotrophic factor is one of the essential growth factors involved in corneal tissue regeneration. However, the method of restoring corneal damage with biodegradable materials based on silk fibroin containing glial neurotrophic factor has not been developed. Aim: To study pathogenetic features of corneal damage repair with biodegradable structures based on silk fibroin containing glial neurotrophic factor. Materials and Methods: The study was conducted on mature male C57BL/6 mice, in which corneal damage was modeled. During the experiment, the area of the epithelial corneal defect was assessed for the intensity of the regenerative process on days 1, 3, and 5 after injury. Results: In the groups of mice where biodegradable structures based on silk fibroin containing glial neurotrophic factor were used, the intensity of the regenerative process was higher compared to the control group (p < 0.05). Conclusion: The use of biodegradable structures based on silk fibroin containing glial neurotrophic factor stimulates the process of corneal tissue regeneration after corneal damage.
BIOMORPHOLOGICAL ANALYSIS OF LIFE FORMS OF ORCHIDS GROWING IN THE FLORA OF NAKHCHIVAN AUTONOMOUS REPUBLIC
Authors: Р.К. Салманова,
Published: January 2023

Морфологические признаки растений характеризуются их жизненными формами, анатомическим строением стебля и листа, особенностями опушения, строением семени и способами его вскрытия. Анализ признаков дает представление об амплитуде изменчивости, редкости, гомологии и параллелизма в системе родства филогенетических линий, а также о характере адаптивных специализаций. Это, в свою очередь, позволяет дифференцировать таксономическое и диагностическое значение признаков, совершенствовать традиционный сравнительно-морфологический метод на материалах их биологического разнообразия. В статье приводятся результаты исследований жизненных форм видов семейства Orchidaceae Juss. во флоре Нахичеванской АР. Во время проведенных исследований были выявлены биоморфологические типы видов орхидей распространенные в флоре Нахчыванской АР следующим образом: корневищные (коротокорневищные), столоновиднокорневищные, тубероидные.

Morphological features of plants are characterized by their life forms, the anatomical structure of the stem and leaf, the features of pubescence, the structure of the seed and the methods of opening it. Analysis of traits gives an idea of the amplitude of variability, rarity, homology and parallelism in the system of kinship of phylogenetic lineages, as well as the nature of adaptive specializations. This, in turn, makes it possible to differentiate the taxonomic and diagnostic significance of characters, to improve the traditional comparative morphological method based on the materials of their biological diversity. The article presents the results of studies of life forms of species of the family Orchidaceae Juss. in the flora of the Nakhchivan Autonomous Republic. During the studies, biomorphological types of orchid species were identified, common in the flora of the Nakhchivan Autonomous Republic as follows: rhizomatous (short-rhizome), stolon-like rhizome, tuberoid.
ADAPTIVE CAPABILITIES OF SOIL NITROGEN-FIXING MICROORGANISMS IN CONDITIONS OF CONTAMINATION WITH HEAVY METAL SALTS
Authors: А.Н. Пархоменко, , А.Р. Гальперина,
Published: January 2023

Изучены особенности влияния Pb(NO3)2, MnSO4, CuSO4 на развитие азотфиксирующих микроорганизмов, выделенных из почв Астраханской области. Установлено, что внесение солей тяжёлых металлов негативно влияет на численность микроорганизмов и способствует увеличению продукции экзополисахаридов. Установлен следующий ряд токсичности на исследуемые культуры: Cu > Mn > Pb.

The peculiarities of the influence of Pb(NO3)2, MnSO4, CuSO4 on the development of nitrogen-fixing microorganisms isolated from the soils of the Astrakhan region have been studied. It has been established that the introduction of heavy metal salts negatively affects the number of microorganisms and contributes to an increase in the production of exopolysaccharides. The following range of toxicity has been established for the studied cultures: Cu > Mn > Pb.
THE VALLEY OF THE STARAYA KUBAN RIVER (BELYY-DZHIGINKA LINE) IN THE LATE VALDAI AND HOLOCENE
Authors: Н.А. Тюнин,
Published: January 2023

В статье рассматривается история участка DŽ-8,9/19 (левобережная часть дна долины Старой Кубани в створе Белый-Джигинка) в последние 25 тыс. лет. Она реконструирована на основе результатов полевого литологического анализа и радиоуглеродного датирования с опорой на опубликованные данные. В пик валдайского оледенения в долине Старой Кубани возник эрозионный врез, ныне заполненный осадками. В новоэвксинскую и бугазскую стадии в долине чередовались озера и плавни. С витязевского времени формируется голоценовая дельтовая толща (7,6-18 м). В голоцене флювиальные ландшафты периодически сменялись лагунами. Их следы: на левобережной периферии (лагуны фаз Каламита-1, Джемете-2, Нимфей-3), в осевой части (пляж фазы Нимфей-4).

The article is devoted to the late 25 ka palaeogeography of the DŽ-8,9/19 site (left-bank bottom of the Staraya Kuban river valley, the Belyy-Dzhiginka line). The reconstruction based on the results of field lithological analysis and radiocarbon dating based on published data. There was erosional depression in the Staraya Kuban river valley in the LGM, now filled with sediments. Lakes and boggy areas were alternated in the Neoeuxinian and Bugaz stages. The Holocene deltaic sediments (7.6-18 m) have been formed since the Vityazevo stage. In the Holocene, fluvial landscapes periodically gave way to lagoons. Their remnants are on the left-bank periphery (lagoons of the Kalamita-1, Dzhemete-2, Nymphaion-3 phases) and in the axial part (the beach of the Nymphaion-4 phase).
THE DEVELOPMENT OF DANGEROUS NATURAL-TECHNICAL PROCESSES ON THE EXAMPLE OF THE SETUN RIVER VALLEY
Authors: И.Н. Смирнов,
Published: January 2023

На примере территории долины реки Сетунь рассматриваются опасные природные и природно-техногенные процессы, развивающиеся в урболандшафтах. Приводится карта с указанием участков проявлений карста, оползней и подтопления.

On the example of the territory of the Setun River valley, dangerous natural and natural-technical processes developing in urban landscapes are considered. A map is provided indicating the areas manifestations of karst, landslides and flooding.
Isolated Tuberculous Epididymitis: A Case Report and Review of the Literature
Authors:   Department of Urology, Clinique St-Jean, Brussels, Belgium, G Vanoverschelde , S Ward ,   Department of Urology, Clinique St-Jean, Brussels, Belgium, P De Wil ,   Department of Urology, Clinique St-Jean, Brussels, Belgium, L Delcarte ,   Department of Urology, Clinique St-Jean, Brussels, Belgium, J Van Damme ,   Department of Urology, Cliniques universitaires Saint-Luc, Brussels, Belgium
Published: January 2023

In 2021, tuberculosis remains a world health problem. It is still the first cause of mortality by infectious disease in the world [1]. Fortunately, in developed countries, tuberculosis is a very rare pathology. Genitourinary tuberculosis has been reported to account for 20% to 73% of all cases of extrapulmonary tuberculosis in the general population [2]. The epididymal involvement accounts for only about 20% of the genitourinary tuberculosis [3]. Isolated genitourinary tuberculosis (GUTB) is a rare and unusual presentation of tuberculosis that occurs in young male or female adults and that can cause infertility [4]. Most of the time, infertility is due to the inflammation and scarring that follow the infection, resulting in distortion of the normal anatomy and causing obstruction of the excretory tract [5]. The disease typically develops slowly. Early diagnosis is difficult, therefore delayed diagnosis and misdiagnosis are common [6].
The Diabetic Platelet
Authors:   Department of Properatory Internal Medicine, AHEPA, Aristotle University School of Medicine, Thessaloniki, Greece, N Neokleous , S Mpountola ,   Department of Properatory Internal Medicine, AHEPA, Aristotle University School of Medicine, Thessaloniki, Greece, V Perifanis ,   Department of Properatory Internal Medicine, AHEPA, Aristotle University School of Medicine, Thessaloniki, Greece
Published: January 2023

Patients with Diabetes Mellitus (DM) have accelerated atherosclerosis, which is the main essential factor contributing to the high risk of atherothrombotic events in these patients. Atherothrombotic complications are the principal cause of morbidity and mortality in patients with DM. Both atherosclerosis and the increased risk of thrombotic vascular events may result from dyslipidaemia, endothelial dysfunction, platelet hyperreactivity, an impaired fibrinolytic balance, and abnormal blood flow. Platelets of DM patients are characterised by dysregulation of several signalling pathways causing increased adhesion, activation and aggregation. Platelet function of patients with DM is complicated by several mechanisms, such as hyperglycaemia, insulin deficiency and resistance, associated metabolic conditions, and cellular abnormalities. The present manuscript purposes to provide a review on the up-to-date status of data on platelet abnormalities that characterise patients with DM.
Quality Improvement Strategies in Cancer Screenings Interrupted by COVID-19 in Primary Care
Authors:   Hackensack Meridian School of Medicine, Nutley, NJ, A Chang , S Dixit ,   Hackensack Meridian School of Medicine, Nutley, NJ, K Ussery-Kronhaus ,   Ocean University Medical Center, Brick, NJ, K Kronhaus ,   Ocean University Medical Center, Brick, NJ
Published: January 2023

COVID-19 caused a quarantine that closed many primary care offices where patients were unable to receive their routine cancer screenings. The delayed cancer screenings lead to increased morbidity and mortality. A literature review of Breast, Cervical, and Colorectal (BCC) cancer screening compared to 2019 indicates that screenings have not returned to pre-pandemic levels. Several strategies were adopted to counteract this disruption including active outreach to at-risk patients, expanding the use of telehealth appointments, and offering home stool assay kits conducted at the patient’s convenience. We looked at whether strategies were effective in a primary care office in NJ. We found that COVID-19 has increased the popularity of using stool-based home kits and made up the majority of CRC screenings, although overall screenings have remained below pre-pandemic levels. Cervical cancer screenings remain at low rates and may benefit from other routes of testing. Home HPV kits could be beneficial in diminishing the deficit and has already seen promising data in prior studies. Breast cancer screenings do not have a home-testing equivalent, however the popularity of telehealth appointments offers the opportunity to reiterate the importance of routine screenings. Telehealth has been shown to be beneficial in getting patients to complete their wellness visits and routine BCC cancer screenings as shown by the increase of wellness visits in the summer of 2020. Despite ongoing efforts, routine BCC cancer screenings remain 5% below what they were compared to 2019 and these strategies must continue beyond COVID-19 to address the BCC cancer screening deficit.
Association of Sociodemographic Factors and Prolonged Recovery Time from Work Disability in Patients with Cervical Sprain in Obregon City, Mexico
Authors:   Department of Family Medicine, Family Medicine Unit #1, Mexico, M Herrera-Castro , JA Corral-Castillo ,   Department of Family Medicine, Family Medicine Unit #1, Mexico
Published: January 2023

Background: Work disability is a medical certification that considers both physical factors and psychophysical conditions of the worker and work conditions. Exceeding the recovery time means a prolonged disability. The most frequent pathologies that incapacitate are cervical injuries (30%), with cervical sprain being the most common. Objective: To determine the association between sociodemographic factors and prolonged time of recovery from disability in patients with a diagnosis of cervical sprain grade 1 and 2 in Obregon City, Mexico. Methods: An analytic cross-sectional study was conducted in the family medicine unit 1 from Obregon City, Mexico. Medical records of 376 disabled workers due to grade 1 and 2 cervical sprain were reviewed. In the bivariate analysis, odds ratio and Chi-Square with a confidence interval of 95% was implemented, a p <0.05 was considered significant Results: Of the 376 disabilities due to general illness, 144(46.6%) were prolonged and 165(53.4%) not prolonged. In disabilities for work risk, 44(65.7%) were prolonged and 23(34.3%) not prolonged, this difference was significative (p=0.005). Conclusions: The variable more associated with prolonged disability wastype of disability (work risk).
The Onset of Pediatric Human Immunodeficiency Infection- Connecting the Dots: Reminiscences of a Newark Pediatrían
Authors:   Professor of Pediatrics, Columbia University Mailman School of Public Health, USA, JM Oleske
Published: January 2023

The screaming started immediately: “It cannot be true! Children cannot get this filthy disease! How dare you claim such a thing?” My response was simple, straightforward and sincere: Why would I make this up? Indeed, there was no upside to determining that infants and children, little kids, were AIDS’ newest casualties, an even more chilling realization since we did not yet know all the ways it could be transmitted. After establishing the parent-child link through several of my original encounters with women with AIDS having very ill and dying infants and children, it took a bit more detective work and time to sift through other cases I suspected would tell the same story. Nevertheless, there it was, in black-and-white clarity: charts from seven additional children I had followed since 1979 also had symptoms and blood work results definitively linked to a parent’s AIDS diagnosis and unfortunately shared a similar fate if not more severe case. Until than AIDS was thought to be acquired by sharing needles or having sex with someone already with AIDS. Now it was becoming clear to me that its littlest victims, infants and children, were infected simply by sharing space in their mother’s womb, if she had been HIV infected.
Study of Serum Electrolytes and Blood Sugar Changes in Children with Severe Acute Malnutrition
Authors:   Senior Pediatrician, Maa Vindhyavasini Autonomous State Medical College, Mirzapur, UP, India, Singh Yogendra Bahadur , S.Sethi Anuj ,   Assistant Professor, Department of Pediatrics, Maharani Laxmi Bai Medical College, Jhansi, UP, India, Verma Manisha ,   Assistant Professor, Department of Pediatrics, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, UP, India, Sethi R.S ,   Former Professor and Head, Department of Pediatrics, Maharani Laxmi Bai Medical College, Jhansi, UP, India
Published: January 2023

The purpose of this study was to look at the serum electrolyte status of malnourished children with and without diarrhoea/vomiting in order to manage serum electrolyte abnormalities in cases of severe acute malnutrition. This prospective observational hospital based study (n=112) carried out at a tertiary care hospital. The enrolled subjects was divided into 2 groups: those who had diarrhoea and/or vomiting (Group A; 42: 37.5%) and those who did not (Group B; 70: 62.5%). 1.5 mL of venous blood in an EDTA vial and 2 mL of venous blood in a plain vial were drawn and sent straight away for further analysis. All patients had the following tests: Blood glucose; CBC; Serum electrolytes (Na+, K+, Ca++). Other investigations, like KFT, ESR, LFT, Urine (R/M), and Stool (R/M) were undertaken to corroborate the diagnosis whenever clinical indicated. Males (65; 58.03%) outnumbered females (47; 41.96%). 73.21% of the patients were between the ages of 6 and 24 months. SAM is more common in lower socioeconomic status 74 (66.07%).SAM was associated with hypokalemia in 7 children, (16.66%), hyponatremia in 6 children (14.28%), hypernatremia in 2 children (4.76%), hypocalcemia in 3 children (7.14%) and hypoglycemia in 3 children (7.14%) in group A (n=42). SAM in Group B (n=70) were associated with hypokalemia in 3 children (4.28%), hyponatremia in 9 children (12.85%), hypernatremia in 5 children (7.14%), and hypocalcemia in 4 children (5.71%). Out of 112 SAM children, 79 children were cured (70.53%). 60 of the 79 cured children (or 75.94%) had achieved their target weight, but just 8 of the 30 defaulter children (or 26.66% of them) had. Electrolytes changes are prevalent in malnourished children, and they can be subclinical or manifest during diarrhoea/vomiting. Although frequency of hypoglycemia was low, measurement of blood sugar and serum electrolytes are helpful to avoid life threatening situation. Despite recent breakthroughs in medicine and technology, severe acute malnutrition remains a problem. Faulty feeding habits, poor supplementary feeding practises, confusion about children's nutritional needs, frequent illnesses, big family size, and low socioeconomic level are all predictors of severe malnutrition. Aside from literacy, there is an urgent need to educate mothers on nutrition, low-cost diets, and breast-feeding methods in order to prevent and treat childhood malnutrition.
Dynamic Observation of Vascular Regeneration in Femoral Head Necrosis: a 5-Year Follow-Up Case Report
Authors:   Department of Traditional Chinese Medicine, Zhejiang Chinese Medicine University, China, WX Zhang , C Zheng ,   Department of Traditional Chinese Medicine, Zhejiang Chinese Medicine University, China, PJ Tong ,   Department of Orthopedic Surgery, Zhejiang Provincial Hospital of TCM, China
Published: January 2023

Femoral Head Necrosis (FHN) is an invasive hip disease of skeletal system, which associated with vascular dysfunction. Therefore, vessels regeneration and follow the posterolateral direction are regarded as a potential therapy target for FHN. We report a case of FHN that was treated by successful regeneration of the internal circumflex femoral artery via targeted Lipoaspirate (LPS) infusion and biomechanical support. A 35-year-old man with FHN involved. LPS isolated from the abdominal subcutaneous fat and infuse into the internal circumflex artery approximately seven times at every 1.5 months in both femoral heads. Besides, the porous tantalum rod was grafted after the first LPS infusion on each side. After the 5-year follow-up study, the primary outcomes showed obvious improvement in the number, distribution, and diameter of blood vessels in the ischemic area. In addition, the patient was now able to perform the daily activities; the congestive area increased from 73.4% to 94.2% on the left side and from 0% to 71.8% on the right side. The Harris Hip Score improved from 22 to 91. Multiple LPS infusions via the internal circumflex femoral artery combined with porous tantalum rod grafting offers an alternative treatment option for FHN.
A Multi-modal Pre-training Transformer for Universal Transfer Learning in Metal-Organic Frameworks
Authors: Kang Yeonghun , Park Hyunsoo , Smit Berend , Kim Jihan
Published: January 2023

Metal-organic frameworks (MOFs) are a class of crystalline porous materials that exhibit a vast chemical space due to their tunable molecular building blocks with diverse topologies. Given that an unlimited number of MOFs can, in principle, be synthesized, constructing structure-property relationships through a machine learning approach allows for efficient exploration of this vast chemical space, resulting in identifying optimal candidates with desired properties. In this work, we introduce MOFTransformer, a multi-model Transformer encoder pre-trained with 1 million hypothetical MOFs. This multi-modal model utilizes integrated atom-based graph and energy-grid embeddings to capture both local and global features of MOFs, respectively. By fine-tuning the pre-trained model with small datasets ranging from 5,000 to 20,000 MOFs, our model achieves state-of-the-art results for predicting across various properties including gas adsorption, diffusion, electronic properties, and even text-mined data. Beyond its universal transfer learning capabilities, MOFTransformer generates chemical insights by analyzing feature importance through attention scores within the self-attention layers. As such, this model can serve as a bedrock platform for other MOF researchers that seek to develop new machine learning models for their work.
Total Disruption of Au Cores and the Formation of Hollow Voids in Au-Pt Bimetallic Nanoparticles
Authors: Song Hyon-Min , Anjum Dalaver H. , Zink Jeffrey I.
Published: January 2023

When homogenized as core-shell structures, the structural instability of Au cores in bimetallic nanoparticles (NPs) has been well documented in the theoretical calculations, yet there are limited examples in the experiments. It is presented in this study that in the presence of Ag(I), Au cores with the average size of 33.0 nm are annihilated with crystalline Au being hardly found when Au NPs are coated with Pt shells, while the crystallinity and size of Au cores remain intact when they are coated with Pd. Strains follow when heterogeneous metals are embedded around Au cores with relatively large size and relatively large interfacial area, and there are ways for releasing the interface energy for Pd: i) twin boundaries and stacking faults on the surface of Pd shells, and ii) small voids around Au cores. When Au NPs are coated with Pt, however, porous structures rather than crystalline structures are observed with twin defects being hardly found, and for alleviating the high surfaces energies of Pt, Au atoms diffuse actively outward. In the absence of Ag(I), significant alloying progresses with no hollow cores observed. Ag(I) is believed to facilitate the segregation of Au to the surfaces, and during this rapid movement, Pt does not diffuse as quickly as Au and consequently hollow cores are generated in the presence of Ag(I).
A Dual UHPLC-HRMS-Based Fecal Metabolomics and Lipidomics Analysis and Automated Data Processing Pipeline for Comprehensive Gut Phenotyping
Authors: Vangeenderhuysen Pablo , Van Arnhem Jasmien , Pomian Beata , De Graeve Marilyn , De Commer Lindsey , Falony Gwen , Raes Jeroen , Zhernakova Alexandra , Fu Jingyuan , Hemeryck Lieselot Y. , Vanhaecke Lynn
Published: January 2023

In recent years, feces has surfaced as the matrix of choice for investigating the gut microbiome-health axis because of its non-invasive sampling and the unique reflection it offers of an individual’s lifestyle. In cohort studies where the number of samples required is large, but availability is scarce, a clear need exists for high-throughput analyses. Such analyses should combine a wide physicochemical range of molecules with a minimal amount of sample and resources, and downstream data processing workflows that are as automated and time efficient as possible. We present a dual fecal extraction and UHPLC-HR-Q-Orbitrap-MS-based workflow that enables widely targeted and untargeted metabolome and lipidome analy-sis. A total of 836 in-house standards were analyzed, of which 360 metabolites and 132 lipids were consequently detected in feces. Their targeted profiling was validated successfully with respect to repeatability (78% CV<20%), reproducibility (82% CV<20%) and linearity (81% R2>0.9), while also enabling holistic untargeted fingerprinting (15 319 features, CV<30%). To automate targeted processing, we optimized an R-based targeted peak extraction (TaPEx) algorithm relying on a database comprising retention time and mass-to-charge ratio (360 metabolites and 132 lipids), with batch-specific quality control curation. The latter was benchmarked towards vendor-specific targeted and untargeted software and our IPO/XCMS-based untargeted pipeline in Lifelines Deep cohort samples (n = 97). TaPEx clearly outperformed the untargeted approaches (81.3 vs. 56.7-66.0% compounds detected). Finally, our novel dual fecal metabolomics-lipidomics-TaPEx method was successful-ly applied to Flemish Gut Flora Project cohort (n = 292) samples, leading to a sample-to-result time reduction of 60%.
2-Propanol Interacting with Co3O4(001):A combined AIMD and vSFS study
Authors: Omranpoor Amir H. , Bera Anupam , Bullert Denise , Linke Matthias , Salamon Soma , Weber Samira , Wende Heiko , Hasselbrink Eckart , Spohr Eckhard , Kenmoe Stephane
Published: January 2023

The interaction of 2-propanol with Co3O4(001) was studied by vibrational sum fre-quency spectroscopy (vSFS) and by ab initio molecular dynamics (AIMD) simulations of 2-propanol dissolved in a water film to gain insight at the molecular level into the pathways of catalytic oxidation. The experimental study has been performed under near ambient condition, where the presence of water vapor is unavoidable, resulting in a water film on the sample and thereby allowing us to mimic the solution-water interface. Both experiment and theory conclude that 2-propanol adsorbs molecularly. The lack of dissociation is attributed to the adsorption geometry of 2-propanol in which the O-H bond does not point towards the surface. Furthermore, the copresent water not only competitively adsorbs on the surface but also inhibits 2-propanol deprotonation. The calculations reveal that the presence of water deactivates the lattice oxygen, thereby reducing the surface activity. This finding sheds light on the multifaceted role of water at the interface for the electrochemical oxidation of 2-propanol in aqueous solution as recently reported. At higher temperatures 2-propanol remains molecularly adsorbedon Co3O4(001) until it desorbs with increasing surface temperature.
Spectroscopic and Computational Study of Organocatalytic Umpolung of Bromocations: An Accelerated Stereoselective Dibromination Protocol
Authors: Panda Jeetendra , Sahoo Jigyansa , Dutta Juhi , Biswal Himansu Sekhar , Sahoo Gokarneswar
Published: January 2023

Herein, the reversal of polarity of cationic bromine, organocatalytically, is presented. NBS, a proven bromocation source was converted to a superior bromoanion reagent by H/Br exchange with a secondary amine, substantiated with spectroscopic and computational evidences. The concept has further been used in a successful accelerated organocatalyzed dibromination of olefins, in a non-hazardous, commercially viable process with a wide substrate scope. The reactivity of key entities has been observed through NMR kinetics and reaction acceleration using 10 mol% of catalyst loading accounts for its major success. The nucleophilicity of the bromoanion was found to be superior in comparison to other nucleophiles such as MeOH, H2O etc. and the protocol dominates over competing allylic bromination reaction.
Model-Driven Design of Redox Mediators: Quantifying the Impact of Quinone Structure on Bioelectrocatalytic Activity with Glucose Oxidase
Authors: Mtemeri Lincoln , Hickey David
Published: January 2023

Successful application of emerging bioelectrocatalysis technologies depends upon an efficient electrochemical interaction between redox enzymes as biocatalysts and conductive electrode surfaces. One approach to establishing such enzyme-electrode interfaces utilizes small redox-active molecules to act as electron mediators between an enzyme active site and electrode surface. While redox mediators have been successfully used in bioelectrocatalysis applications ranging from enzymatic electrosynthesis to enzymatic biofuel cells, they are often selected using a guess-and-check approach. Herein, we identify structure-function relationships in redox mediators that describe the bimolecular rate constant for its reaction with a model enzyme, glucose oxidase (GOx). Based on a library of quinone-based redox mediators, a quantitative structure-activity relationship (QSAR) model is developed to describe the importance of mediator redox potential and projected molecular area as two key parameters for predicting the activity of quinone/GOx-based electroenzymatic systems. Additionally, rapid scan stopped-flow spectrophotometry was used to provide fundamental insights into the kinetics and the stoichiometry of reactions between different quinones and the flavin adenine dinucleotide (FAD+/FADH2) cofactor of GOx. This work provides a critical foundation for both designing new enzyme-electrode interfaces and understanding the role that quinone structure plays in altering electron flux in electroenzymatic reactions.
Hemangioma of temporal bone. Case report
Authors: Saidulaev Vakharsolta A. , Diab Khassan M.A. , Daikhes Nikolai A. , Garashchenko Tatiana I. , Iunusov Adnan S. , Pashchinina Olga A. , Umarov Parviz U.
Published: January 2023

Hemangioma of temporal bone or intratemporal hemangioma is a rare benign tumor that has no specific symptoms and signs according to computed tomography, magnetic resonance imaging), which makes it difficult to diagnose it early. The percentage of diagnostic errors is quite high. The symptoms of hemangioma of temporal bone depends on its localization. A common localization of hemangioma in the temporal bone is geniculate ganglion and internal auditory canal. According to CT and MRI data, there is no difference between many tumors usually localized in the temporal bone. Angiography complements the preoperative examination, increases the likelihood of a correct diagnosis, and is used to assess the possibility of preoperative embolization. Surgical treatment used in many cases, the purpose of which is the total removal of the tumor. A clinical case of temporal bone hemangioma in a 12-year-old child is presented.
Norwegian scabies in children. Case report
Authors: Belikov Alexander N. , Golubeva Polina A. , Petrenko Ekaterina V. , Sheremeteva Natalya V. , Iuditskaia Margarita V. , Korsunskaya Irina M.
Published: January 2023

Norwegian scabies is a highly contagious form of scabies that is quite common in immunosuppressed patients. Given the atypical clinical presentation, this form of the disease may remain undiagnosed for a long time. Norwegian scabies is often reported in elderly patients but can also occur in children. This article presents a clinical case of a 6-year-old patient to draw the attention of specialists to this disease in pediatric practice.
DEVELOPMENT OF CLUSTER RELATIONSHIPS IN KYRGYZ AGRICULTURAL SECTOR UNDER EURASIAN ECONOMIC UNION MEMBERSHIP
Authors: Азиза Баймаматовна Карбекова,
Published: January 2023

Цель статьи состоит в исследовании опыта организации, функционирования и развития кластерных структур в странах дальнего зарубежья и государствах-участниках Евразийского экономического союза. Успешное решение вопросов усиления территориально-отраслевой дифференциации сельскохозяйственного производства на евразийском пространстве в значительной степени обусловит повышение эффективности функционирования аграрного сектора ЕАЭС. Научная новизна заключается в предложенной автором модели формирования и развития трансграничных агропродовольственных кластеров в рамках Евразийского экономического Союза, включающей в себя целевые ориентиры, алгоритм реализации, инструментарий межсоюзного территориального планирования воспроизводственных процессов, пилотные агрокластеры. Адекватное использование факторов производства, природно-климатических условий, а также различного рода ресурсов государств-членов Союза будет способствовать динамичному росту валового выпуска сельскохозяйственной продукции, сырья и продовольствия, повышению конкурентоспособности экономических субъектов указанной сферы, снижению зависимости от импортных поставок из третьих стран и увеличению экспортного потенциала ЕАЭС, совершенствованию межрегионального обмена внутри данного интеграционного объединения.

The purpose of the article is to investigate the experience of organizing, functioning and developing cluster structures in non-CIS countries and member states of the Eurasian Economic Union. The successful solution of the issues of strengthening the territorial and sectoral differentiation of agricultural production in the Eurasian space will largely determine the increase in the efficiency of the functioning of the agricultural sector of the EAEU. The scientific novelty lies in the model proposed by the author for the formation and development of cross-border agri-food clusters within the framework of the Eurasian Economic Union, which includes: targeted guidelines, an implementation algorithm, tools for inter-union territorial planning of reproductive processes, pilot agro-clusters. Adequate use of production factors, natural and climatic conditions, as well as various kinds of resources of the member states of the Union, will contribute to the dynamic growth of gross output of agricultural products, raw materials and food, increase the competitiveness of economic entities in this area, reduce dependence on imports from third countries and increase the export potential of the EAEU, improve interregional exchange within this integration associations.