bluuebunny/crossref_metadata_2025 huggingface dataset:
Plasma rich in growth factors (PRGF) and leukocyte-platelet rich fibrin (L-PRF): comparative release of growth factors and biological effect on osteoblasts
Authors: Baca-Gonzalez Laura , Serrano Zamora Rebeca , Rancan Lisa , González Fernández-Tresguerres Francisco , Fernández-Tresguerres Isabel , López-Pintor Rosa M. , López-Quiles Juan , Leco Isabel , Torres Jesús
Published: October 2022

Purpose

To compare the release of platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF-I) and interleukin 1β (IL-1β) of plasma rich in growth factors (PRGF) and leucocyte platelet-rich fibrin (L-PRF) and to evaluate their biological implication in osteoblasts.

Methods

Blood from 3 healthy volunteers was processed into PRGF, immediate L-PRF (L-PRF 0ʹ) and L-PRF 30 min after collection (L-PRF-30ʹ) and a control group. Growth factors release were analyzed at 7 times by ELISA. Cell proliferation, collagen-I synthesis and alkaline phosphatase activity were assessed in primary cultures of human osteoblasts.

Results

A slower controlled release of IGF-I, VEGF and PDGF was observed in the PRGF group at day 14. A higher synthesis of type I collagen was also quantified in PRGF. L-PRF released significantly higher amounts of IL-1β, that was almost absent in the PRGF.

Conclusions

The addition of leukocytes dramatically increases the secretion of proinflammatory cytokines, which are likely to negatively influence the synthesis of type I collagen and alkaline phosphatase (ALP) by osteoblasts.
Analysis of the drivers of ASF introduction into the officially approved pig compartments in South Africa and implications for the revision of biosecurity standards
Authors: Stoffel Carla , Buholzer Patrik , Fanelli Angela , De Nardi Marco
Published: October 2022

Background

While African Swine Fever (ASF) virus has historically circulated in wild pigs and inOrnithodorosticks in parts of South Africa, the virus has spread among domestic pigs throughout the country since 2019. South Africa’s compartment system has been used as a mainstay approach to protecting the swine industry in the face of ASF. However, in 2020, two compartments broke down with ASF. The objectives of this study are to investigate the drivers for ASF introduction into the compartments, to categorize compartments by risk of ASF introduction, and to make corresponding recommendations. The relevance of risk factors for ASF introduction for each compartment were investigated among veterinarians and farm managers. The analysis of risk factors weighted according to an expert elicitation were used to categorize compartments into risk levels.

Results

Drivers of disease related to human behaviors and to domestic pig management are perceived by farm managers and veterinarians of the compartments to be critical for ASF introduction into compartments in South Africa. Twenty-four units were categorized as high risk, forty-seven as medium risk, and twenty-four as low risk. “Insufficient boot and clothing biosecurity by animal health personnel” was identified as a relevant risk factor in all high risk units. Other prominent risk factors were “insufficient boot and clothing biosecurity by external people,” “underreporting of suspect ASF cases,” “improper hunting/ culling of wild suids inside the compartment,” “un-tested introductions into the herd,” and “entry and contact with free-roaming pigs.” The roles of wild pigs and competent vectors are considered minimal. There is a need for revision of the compartment standards and training of compartment personnel on the standards. The major gaps identified in the standards were absence of a monitoring programme to assess biosecurity implementation and suboptimal surveillance testing and audit strategies.

Conclusions

The results of our study confirm that ASF is increasingly an anthropogenic problem. Updating the compartment standards and addressing gaps in the knowledge of compartment personnel on ASF are most critical. To enhance compliance with biosecurity measures and thus control the disease, close engagement with all stakeholders linked to the compartments is needed.
Iatrogenic right coronary artery occlusion during minimally invasive cardiac surgery-tricuspid annuloplasty—a case report
Authors: Urabe Daichi , Ide Masahiro , Matsuoka Motoyuki , Miyake Ryuichiro
Published: October 2022

Although rare, right coronary artery (RCA) injury is a serious complication of tricuspid annuloplasty (TAP) and warrants close attention. We report a case of ST elevation myocardial infarction secondary to iatrogenic RCA occlusion during minimally invasive cardiac surgery (MICS). Electrocardiography (ECG) revealed ST segment elevation in lead II. Transesophageal echocardiography (TEE) revealed inferior wall hypokinesis after cardiopulmonary bypass, and coronary angiography revealed peripheral RCA occlusion. Intraoperatively, we detected an atrioventricular groove deformity during the second surgical procedure. Wall motion and ECG abnormalities showed normalization after TAP was reestablished. Vigilant monitoring using TEE and ECG is important to detect intraoperative myocardial ischemia during MICS-TAP.
Prevalence of different patterns of dyslipidemia in patients with type 2 diabetes in an Iranian population
Authors: Yadegar Amirhossein , Mohammadi Fatemeh , Rabizadeh Soghra , Qahremani Reihane , Esteghamati Alireza , Nakhjavani Manouchehr
Published: October 2022

Background

Diabetic dyslipidemia is a complex multidimensional abnormality. However, earlier studies did not focus on the prevalence of various patterns of dyslipidemia. We categorized dyslipidemia into three groups. Single dyslipidemia (7 patterns) and mixed dyslipidemia consisted of dual (16 patterns) and triple (4 patterns) combinations of different patterns of single dyslipidemia.

Methods

This cross-sectional study included 2097 patients with type 2 diabetes (T2D) between 2014 and 2021. We measured blood lipid profile parameters and calculated the atherogenic index of plasma (AIP) using log (TG/HDL-C). We analyzed dyslipidemia as a categorical variable and expressed results as numbers and percentages. We used Chi-square or Fisher exact tests to compare categorical variables.

Results

A total of 97.81% of patients had at least one lipid abnormality. High AIP (88.0%) was the most common pattern, followed by LDL-C ≥ 70mg/dl (80.1%), and low HDL-C (58.0%). 73.87% of patients had mixed dyslipidemia. The dual combination of high AIP and LDL-C ≥ 70mg/dl was the most common pattern of mixed dyslipidemia (71.1%). Additionally, 24.7% of patients had triple combination dyslipidemia. All dyslipidemia patterns were more common among women than men, except for high AIP. In patients with T2D and coronary artery disease (CAD) history, high AIP was the most prevalent pattern of dyslipidemia (87.5%), followed by LDL ≥ 70mg/dl (68.6%). Also, the dual combination of high AIP and LDL ≥ 70mg/dl was the most common pattern of mixed dyslipidemia in patients with T2D and CAD history (60.67%).

Conclusion

This study showed that single and mixed (dual and triple combination) dyslipidemia is common among patients with T2D. High AIP and LDL-C ≥ 70mg/dl were the most common patterns, either single or combined, in patients with or without CAD.
Onset of depression and anxiety among patients with gout after diagnosis: a population-based incident cohort study
Authors: Howren Alyssa , Sayre Eric C. , Choi Hyon K. , Avina-Zubieta J. Antonio , Shojania Kam , Park Jamie Y. , De Vera Mary A.
Published: October 2022

Background

Gout may be associated with an increased incidence of mental health disorders, however, published findings have been limited and inconsistent. Therefore, our objective was to conduct a population-based cohort study to evaluate the incidence of depression and anxiety after gout diagnosis.

Methods

We used linked population-based administrative health data in British Columbia, Canada that includes information on demographics, outpatient visits, and inpatient visits from the period of January 1, 1990 to March 31, 2018. We assessed depression and anxiety using validated International Classification of Diseases, 9th and 10th Revision coding algorithms. We applied multivariable Cox proportional hazard models to evaluate incident depression and anxiety among patients with gout in comparison to non-gout controls, adjusting for age, sex, neighbourhood income quintile, residence, comorbidities, and health care utilization.

Results

We included 157,426 incident cases of gout (60.2% male; mean age 57.1 years) and 157,426 non-gout controls (60.2% male; mean age 56.9 years). The incidence rate of depression among individuals with gout and non-gout controls was 12.9 (95% confidence interval [CI] 12.7–13.2) and 11.1 (95% CI 10.9–11.4) per 1000 person-years, respectively. The incidence rate of anxiety for those with gout was 5.4 (95% CI 5.3–5.5) per 1000 person-years and for non-gout controls was 4.6 (95% CI 4.4–4.7) per 1000 person-years. Individuals with gout had an increased onset of depression (adjusted hazard ratio [aHR], 1.08; 95% CI 1.05–1.11) and anxiety (aHR, 1.10; 95% CI 1.05–1.14) compared to non-gout controls.

Conclusion

Our population-based study shows an increased incidence of depression and anxiety following gout diagnosis in comparison to non-gout controls. Findings suggest the importance of considering psychiatric impacts in addition to the physical impacts of gout.
Novel evaluation of the expression patterns CD44 and MMP9 proteins in intracranial meningiomas and their relationship to the overall survival
Authors: Abd Elhakeem Ahmed Abd Esattar , Essa Abdelhakeem A. , Soliman Radwa Kamel , Hamdan Ali Rabee Kamel
Published: October 2022

Background

Meningiomas are common primary brain neoplasms. CD44 is a cell surface glycoprotein receptor that is involved in matrix-mediated cell signaling and cell–matrix adhesion. Matrix metalloproteinase-9 (MMP-9) plays important role in angiogenesis and tumor invasion. The expression of CD44 protein membranous and cytoplasmic (CD44M and CD44C) has been reported in several tumors (such as lobular carcinoma, renal cell carcinoma, sinonasal melanoma, and lymphoma) except CNS tumors.

Methods

This study addressed the expression of CD44M and CD44C and MMP9 proteins in intracranial meningiomas and their relationship to overall survival. The expression patterns of CD44M&C and MMP-9 proteins were examined in 32 cases of benign meningiomas, 12 cases of atypical meningiomas, and 6 cases of anaplastic meningiomas using immunohistochemical staining methods.

Results

There was more evidence of CD44M expression in atypical and anaplastic meningioma (p =  < 0.001). Interestingly, Spearman correlation analyses revealed significant positive correlation between CD44M and MMP9 protein (r = 0.572, p =  < 0.001) in spite of the negative correlation between MMP9 and CD44 score (r = − 0.035 p = 0.405). There was a significant association between Ki67 protein expression and the grade of meningiomas (p < 0.001) and gender (p = 0.026). There was a significant correlation between overall survival (OS) and age, gender, tumor grade, and Ki-67.

Conclusions

Extensive CD44M expression in high-grade meningioma may reflect a tendency toward more invasive power of meningioma cells into surrounding structures (dura, bone, and brain).CD44M/MMP-9 axis presented by this study is open for future investigations.
The effect of exercise on anti-Mullerian hormone levels in patients with polycystic ovary syndrome: a systematic review and meta-analysis
Authors: Kazeminia Mohsen , Rajati Fatemeh , Rajati Mojgan
Published: October 2022

Background

Polycystic ovary syndrome (PCOS) is considered as the most common endocrinopathy among women of childbearing age and the most important cause of anovulatory infertility. The present study aimed to estimate the pooled effect of exercise on anti-Mullerian hormone (AMH) levels in PCOS women using systematic review and meta-analysis.

Main body

The present study was conducted according to the PRISMA guidelines from 2011 to October 2021. All published studies, which met the inclusion criteria, were searched in SID, MagIran, Embase, PubMed, Scopus, Web of Science (WoS) databases, and Google Scholar motor engine using related MeSH/Emtree terms, which were combined with free text word. Finally, 12 articles were included in the meta-analysis. As a result of the combination of the studies, after exercise, AMH level in the intervention group significantly decreased up to 0.517 ± 0.169 more than that in the control group (P ˂ 0.05). The results of subgroup analysis demonstrated that the effect of resistance training for 16 weeks was higher on women with body mass index (BMI) (≥ 25 kg/m2) and AMH (≥ 10 ng/mL) before the intervention. GRADEpro software was used to grade the level of evidence.

Conclusion

This systematic review and meta-analysis showed that either strength exercise or aerobic exercise decrease the AMH level in PCOS women. It seems more duration of the exercise has a more potential advantage to reduce the AMH levels in women with PCOS. Although the results graded by very low-quality evidence, it is recommended to include exercise in the treatment programs of PCOS patients.
Angiographic patterns of coronary artery disease in young patients presenting at a tertiary cardiac center
Authors: Abdul Wajid Khan Faisal  , Ghalib Habib  , Samra Yasmin  , Waqas Latif  , Sheeraz Ahmad
Published: October 2022

Objective: To compare the patterns of coronary artery disease (CAD) between young adults <35 years of age and patients >35 years of age.

Methods: The observational retrospective study was carried out in angiography department of emergency at Punjab Institute of Cardiology, Lahore between January 2020 and October 2020. Patients ≤35 years old were in Group-I whereas patients >35 years who served as controls were in Group-II. Patients with unstable angina, non-ST and ST elevation MI all were included. The patients with previous history of CAD (CABG/PCI) and angiography done for other purposes i.e., before valvular surgery or PPM implantation were excluded.

Results: Out of 1268 patients, 552 were in Group-I and 716 were in Group-II. The prevalence of normal coronaries/ mild CAD was higher in Group-I i.e., 224(40.6%) than in Group-II i.e., 64 (8.9%). Single vessel disease (SVD) was comparable in both the groups 185 (33.5%) vs. 216 (30.2%). Double vessel disease and triple vessel disease (TVD) was common in Group-II and left main stem (LMS) involvement was also significantly higher in Group-II i.e., 32 (4.5%) vs. 8 (1.4%). Clot in coronary arteries with or without underlying CAD was seen more frequently in Group-I, 61(11.1%) vs. 34 (4.7%). Presence of clot was seen mostly in those patients who had moderate coronary artery disease.

Conclusion: Young patients have different coronary artery disease patterns, so the management strategy must be different in this population. Majority of the young patients have non severe disease. Clot formation is commonly seen in young adults with moderate CAD.

doi: https://doi.org/10.12669/pjms.38.8.6162

How to cite this:Faisal AWK, Habib G, Yasmin S, Latif W, Ahmed S. Angiographic patterns of coronary artery disease in young patients presenting at a tertiary cardiac center. Pak J Med Sci. 2022;38(8):---------. doi: https://doi.org/10.12669/pjms.38.8.6162

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Εκπαιδευτική Πολιτική και Ιστορία. Με αφορμή την έρευνα «Ρόδος – Γιάννενα: αντιδιαμετρικά στο χάρτη. Χαρτογραφώντας και ερμηνεύοντας συγκλίσεις και αποκλίσεις στην ιστορική κουλτούρα εκπαιδευτικών και μαθητών»
Authors: Κιμουρτζής Παναγιώτης
Published: October 2022

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Η αρχική εκπαίδευση / κατάρτιση των εκπαιδευτικών που διδάσκουν Ιστορία: η ελληνική πραγματικότητα, η ευρωπαϊκή πολιτική και οι «συστάσεις» του Συμβουλίου της Ευρώπης και κάποια ερωτήματα…
Authors: Σακκά Βασιλική
Published: October 2022

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Δημιουργική εκμάθηση γλωσσών: «Το Ημερολόγιο Ταυτότητας»
Authors: Κούρτη-Καζούλλη Βασιλεία
Published: October 2022

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Το «αντικείμενο μικρό α» και η κοινωνική θεωρία
Authors: Παντελαίου Τόνια
Published: October 2022

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Μια κοινωνιολογική και ιστορική παρουσίαση της Στατιστικής
Authors: Αθανασιάδης Ηλίας
Published: October 2022

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The Pedagogic Discourse of the Greek School Science Textbooks of Primary and Lower Secondary Level
Authors: Koulaidis Vasilis , Dimopoulos Kostas
Published: October 2022

The aim of this paper is the mapping of the pedagogic discourse in the Greek school science textbooks of the primary and lower secondary level. School science textbooks are considered as means of regulating the pedagogic discourse of each of the educational levels. This approach stems from the view that science education (and education in general) is a socialization process into the practices and conventions (i.e. the discourses) of sub-communities, in our case of the scientific community (Lemke, 1990). Within the framework of this view, science textbooks have a central role to play in this socialising process as a resource for shared meaning making (Lemke, 1990; Bazerman, 1998).
Η εκμάθηση της Αγγλικής γλώσσας σε Ευρωπαϊκά δημοτικά σχολεία με τη βοήθεια της ηλεκτρονικής επικοινωνίας
Authors: Κοσμάς Βλάχος
Published: October 2022

Η εργασία αυτή αναφέρεται στη διδασκαλία των ξένων γλωσσών στο δημοτικό σχολείο και ειδικότερα στην εκμάθηση της Αγγλικής. Η έρευνα που παρουσιάζεται στηρίζεται σε σχετική διδακτορική διατριβή που εκπονήθηκε στο παιδαγωγικό Τμήμα Δημοτικής Εκπαίδευσης του Πανεπιστημίου Αιγαίου. Η διατριβή μελέτησε τη χρήση του διαδικτύου και της ασύγχρονης ηλεκτρονικής επικοινωνίας για την ανάπτυξη και την εμπέδωση της Αγγλικής ως ξένης γλώσσας σε ευρωπαϊκά δημοτικά σχολεία.
Μετασχηματισμός: ένα κεντρικό ζήτημα στη μάθηση και στη διδασκαλία
Authors: Σκούρτου Ελένη
Published: October 2022

Σε πολλά κείμενα που αναφέρονται σε ζητήματα μάθησης και οργάνωσης της διδασκαλίας η έννοια του μετασχηματισμού είναι κεντρική. Με αφορμή το κείμενο του Α. Σοφού στο παρόν τεύχος, στο οποίο (στην παράδοση του Kron) ανα-φέρεται ότι: «…ο εκπαιδευτικός καλείται να «μετασχηματίσει» την ακαδημαϊκή/σχολική γνώση, δηλαδή τις επιστημονικές γνώσεις, θεωρώντας τις, όχι ως δευτερογενείς γνώσεις, τις οποίες πρέπει να μεταφέρει στους μαθητές χωρίς καμία παιδαγωγική και διδακτική παρεμβολή, αλλά ως ση-μείο αναφοράς για τη δημιουργία εκπαιδευτικών περιβαλλόντων εργασίας από όπου θα πα-ραχθούν γνώσεις», θα επιχειρήσουμε σε αυτό το σημείωμα να αναφερθούμε στις δύο όψεις του μετασχηματισμού: στο μετασχηματισμό της γνώσης από την πλευρά του μαθητή και στο μετασχηματισμό της γνώσης από την πλευρά του εκπαιδευτικού.
Κόποις» ή «copies»; Μαθητικές/ φοιτητικές αφηγήσεις και κοινωνική ποιητική
Authors: Benincasa Luciana
Published: October 2022

Adopting a voluntaristic approach, this paper aims to highlight the creativity of social actors. My objectives are (a) to examine examples of the dominant meritocratic narrative in students’ interview discourse and (b) to present an example of the way in this same narrative is challenged by other student narratives. I use two types of data from student culture: (a) excerpts from newspaper interviews with students, referred to as the “first of the first”, who were admitted with the highest marks to very prestigious university departments and (b) a well-known student saying about achievement. The students’ interview discourse resounds with the ideology of effort, described as the road to success and endorsed by educational and political authorities alike. The saying in question, on the other hand, proposes a very different narrative, according to which success is the result of cheating. More than being just different, this alternative narrative openly questions and even ridicules official narratives and the ideology that backs them. This is discussed as an aspect of “social poetics” (Herzfeld).
Παιδαγωγική και Διδακτική Αξιοποίηση των Νέων και Ψηφιακών Μέσων στο Κολλέγιο Ρόδου
Authors: Σπύρου Σπύρος , Χατζηχρήστου Ελένη , Αντωνιάδης Κώστας
Published: October 2022

Ζούμε στην εποχή της ολοένα αυξανόμενης ψηφιακής τεχνολογίας, η οποία δημιουργεί νέα δεδομένα και νέες ανάγκες στις κοινωνίες που επιθυμούν να συμβαδίζουν με την τεχνολογική πρόοδο. Ο σύγχρονος πολίτης, ως τεχνολογικά εγγράμματος, πρέπει να έχει την ικανότητα να εντοπίζει, να οργανώνει, να κατανοεί, να αξιολογεί και να παράγει πληροφορίες, χρησιμοποιώντας την ψηφιακή τεχνολογία. Ο τεχνολογικός ή ψηφιακός εγγραμματισμός, τόσο των μαθητών όσο και του προσωπικού ήταν και είναι για το Κολλέγιο Ρόδου ένας από τους πρώτιστους στόχους του. Από τα πρώτα χρόνια λειτουργίας του κατάφερε να προωθήσει την κατάλληλη κουλτούρα μιας σχολικής μονάδας μέσα στην οποία θα μπορούσαν να αναπτυχθούν και να ακμάσουν άνθρωποι τεχνολογικά εγγράμματοι σε όλα τα επίπεδα. Στο άρθρο που ακολουθεί θα αναλυθεί η κουλτούρα τεχνολογικής εγγραμματοσύνης που ακολουθεί το Κολλέγιο Ρόδου.
Οι φορητοί υπολογιστές στην εκπαίδευση: Μελέτη περίπτωσης ως προς τις συνέπειες στη διδασκαλία και το μιντιακό γραμματισμό
Authors: Σπανός Δημήτρης
Published: October 2022

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Η Αισθητική – Καλλιτεχνική Εκπαίδευση στην ευρύτερη Νησιωτική Περιοχή της Δωδεκανήσου
Authors: Καμπουροπούλου Μαίρη
Published: October 2022

The dialectical relationship between the traditional and the contemporary, which surrounds every human expression, is the dominant feature of both art and architecture, as manifested in practice and theory and is the subject of this study. The aim is to search, investigate through all the elements that coexist in traditional and modern environment, those constants that can seem beneficial in interpretation, in experiencing and recreating the Greek island tradition.

A child who is going to be an islander, a tomorrow's citizens learns to be inspired by the cultural heritage seeking to offer to the society through rebuilding, changing and adaptation that will stem from the historical validity, modern trends and expressed improvement and progress. The reciprocal relationship between traditional and modern art provides to a child a holistic approach to the environment, giving impulses of high quality in different areas, such as History, Architecture, Folklore, Literature, Culture in producing quality goods. The global approach of an aesthetic education that begins in early childhood is one of the sectors that can effectively help in this direction: awareness of the need for maintenance and upgrading of tradition with a view to productive coupling of traditional with modern.
Τα πολυμέσα στην εκπαίδευση. Ανάπτυξη και αξιολόγηση εφαρμογής για τη διδασκαλία στοιχείων Αστρονομίας σε μαθητές της Στ΄ δημοτικού
Authors: Φωκίδης Εμμανουήλ , Λιάνου Πολυξένη
Published: October 2022

Η εργασία εξετάζει τα μαθησιακά αποτελέσματα πολυμεσικής εφαρμογής που έχουν ως στόχο τη διδασκαλία στοιχείων Αστρονομίας σε μαθητές της Στ΄ τάξης. Κίνητρο για την ανάπτυξη της εφαρμογής ήταν οι δυσκολίες και τα προβλήματα που συναντούν οι μαθητές σε θέματα Αστρονομίας. Μία ομάδα μαθητών χρησιμοποίησε αποκλειστικά την πολυμεσική εφαρμογή, σε μία άλλη οι μαθητές δούλεψαν ομαδικά, ενώ μία τρίτη ομάδα αποτέλεσε την ομάδα ελέγχου και διδάχθηκε συμβατικά. Το ερευνητικό πρόγραμμα υλοποιήθηκε σε δημοτικά σχολεία της Καστοριάς και συμμετείχαν 62 μαθητές. Δεν παρατηρήθηκαν στατιστικά σημαντικές διαφορές μεταξύ των επιδόσεων των δύο πρώτων ομάδων, όμως και οι δύο είχαν καλύτερα αποτελέσματα από την ομάδα ελέγχου. Τα ευρήματα κρίνονται ως αξιόλογα, γιατί δείχνουν ότι οι μαθητές που χρησιμοποίησαν την εφαρμογή, χωρίς άλλη διδακτική στήριξη, είχαν εξίσου καλά ή καλύτερα αποτελέσματα σε σχέση με πιο συμβατικές μεθόδους διδασκαλίας.
Η δομική βία στα εν χρήσει σχολικά βιβλία των Θρησκευτικών της Δευτεροβάθμιας Εκπαίδευσης
Authors: Τσέκου Αικατερίνη
Published: October 2022

The purpose of this research is to document the structural violence as projected in textbooks of of Religious Education of Junior and Senior High schools. Six (6) textbooks of Religious Education of Junior and Senior High schools are the subject of the research work. The method used is the qualitative content analysis. The analysis reveals that the examined textbooks of Religious Education, condemn the structural violence which is linked to socio-economic and political incentives in order for pupils to acquire similar attitudes and behaviors to become active citizens in building peaceful and evenhanded societies.
Από το Λόγο στο Γραμματισμό: Η Κριτική Ανάλυση Λόγου ως μεθοδολογικό εργαλείο ανάδειξης των κοινωνικών πρακτικών του Λόγου
Authors: Διαμαντής Φώτιος
Published: October 2022

Το παρόν άρθρο αποσκοπεί στο να φωτίσει τον τρόπο με τον οποίο η Κριτική Ανάλυση Λόγου (ΚΑΛ) χρησιμοποιείται ως μεθοδολογικό εργαλείο, προκειμένου να αναδειχθούν οι κοινωνικές πρακτικές του Λόγου. Ο «Λόγος» σε αυτή την περίπτωση αντιδιαστέλλεται από τον «λόγο», ο οποίος αναφέρεται στη «γλώσσα στη χρήση». στο πώς, δηλαδή, η γλώσσα χρησιμοποιείται κατ’ αρχάς για να θεσπίσει δράσεις και ταυτότητες. Όταν ο λόγος ενσωματωθεί με μη γλωσσικά στοιχεία, προκειμένου να αναγνωριστούν διαφορετικές δράσεις και ταυτότητες ή να πριμοδοτηθούν ορισμένα συµβολικά συστήµατα και τρόποι γνώσης, τότε θεωρούμε ότι εμπλέκεται ο Λόγος. Το ενδιαφέρον για τον Λόγο που υπάρχει εδώ και δεκαετίες στη φιλοσοφία και στις κοινωνικές επιστήμες σχετίζεται άμεσα με τις κοινωνικές πρακτικές, με τις οποίες και μέσα από τις οποίες τα υποκείμενα συλλαμβάνουν και επικοινωνούν τις ερμηνείες τους για την κοινωνική πραγματικότητα. Σ’ αυτήν τη διάσταση, ο Λόγος εκλαμβάνεται ως αναπόσπαστο μέρος και ως ειδικό εργαλείο στο πλαίσιο συγκεκριμένων κοινωνικών πρακτικών. Οι κοινωνικές όμως πρακτικές σχετίζονται σε κάποιο βαθμό με πρακτικές γραμματισμού και έτσι αρθρώνουν, αλλά και αρθρώνονται, μέσα σε και μέσα από συγκεκριμένους παιδαγωγικούς Λόγους. Αυτά τα δημιουργικά χαρακτηριστικά του Λόγου θεωρήσαμε ότι μπορούν να αναδειχθούν μέσω της ΚΑΛ, στοιχείο που αποτέλεσε και την υπόθεση εργασίας στην παρούσα μελέτη.
Εκπαίδευση Ενηλίκων: Ο κριτικός στοχασμός σε ένα σύγχρονο μοντέλο μάθησης
Authors: Παπαχρήστου Μαρία
Published: October 2022

Σε αυτή τη μελέτη, βασικός μας στόχος είναι να ορίσουμε με σαφήνεια τον όρο «κριτικός στοχασμός», αλλά και να προσδιορίσουμε την σημασία της έννοιας αυτής μέσα στο πεδίο της Εκπαίδευσης Ενηλίκων. Στη σύγχρονη εποχή, η Εκπαίδευση Ενηλίκων συνιστά ένα ιδιαίτερο μοντέλο μάθησης το οποίο σηματοδοτεί ένα νέο παιδαγωγικό πλαίσιο, έξω από την παραδοσιακή εκπαίδευση, άμεσα συνδεδεμένο με την οικονομική ανάπτυξη και την κοινωνική ευημερία. Κομβικό ρόλο στην υπόθεση του «κριτικού στοχασμού» αποτελεί η παρουσία της εμπειρίας. Επομένως, θα πρέπει να αναδείξουμε τον τρόπο με τον οποίο το στοιχείο της εμπειρίας  καθορίζει τον μηχανισμό προσέγγισης της γνώσης, πώς αυτή η γνώση, στη συνέχεια, μετασχηματίζει την πραγματικότητα σε υποκειμενική, ανατροφοδοτούμενη και μεταλλασσόμενη αλήθεια. Για το σκοπό αυτό θα παρουσιάσουμε και θα αναλύσουμε τις κυριότερες βιβλιογραφικές πηγές και αναφορές οι οποίες, σε ένα πρώτο επίπεδο θα μας εξοικειώσουν με τις σύγχρονες παιδαγωγικές αντιλήψεις και σε ένα δεύτερο επίπεδο, θα μας βοηθήσουν να συλλάβουμε το πώς ο άνθρωπος, μέσα από τους σύγχρονους παιδαγωγικούς μηχανισμούς που εισάγει η Εκπαίδευση Ενηλίκων, οδηγείται να επανεφεύρει τον εαυτό του και να επαναπροσδιορίσει τη σχέση του και τη γνώση του για το περιβάλλον που τον περικλείει.
Βιβλιοπαρουσίαση: Σχεδιάζοντας σενάρια διδασκαλίας για την πρακτική άσκηση των φοιτητών. Ολιστικό μοντέλο διερευνητικής και στοχαστικής πρακτικής για την ενίσχυση του ψηφιακού γραμματισμού στο πλαίσιο της μεντορείας
Authors: Χατζηδήμου Δημήτριος
Published: October 2022

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Smart city perspectives in post-pandemic governance: Externalities reduction policy
Authors: Vladimirovna Kalinina Olga , Evgenievich Barykin Sergey , Mikhailovich Sergeev Sergey , NikolaevnaSemenova Galina , Fatkullina Alina , Mikhaylov Alexey , De La Poza Plaza Elena
Published: October 2022

Background: The ongoing COVID-19 quarantine restrictions have caused multiple sharp decreases in activities associated with the movement of large masses of people. The economies of regions and cities that are critically dependent on tourist flows related to various segments have suffered. This research aims to provide an economic-mathematical model of smart cities externalities’ impact from the point of view of achieving social and environmental goals

Methods: The objective of this study was to develop an algorithm for supporting decision-makers. Methods of mathematical modeling, statistical processing of data received in real-time, as well as methods for finding solutions by expansion into dynamic series are used, and the theory of mathematical games is applied. The theoretical mathematical model presented considers the statistical processing of data provided in real time referring to the performance indicators of megacities.

Results: The activities of administrations and governments aimed at maintaining stability over the past two years have been aimed at reducing the negative impact of the pandemic. The prospect of returning to normal conditions is complicated by a number of factors. The proposed approach allows the development of the fundamental basis for making administrative decisions within individual megapolises and in environmental policy on a territory of any scale. The developed mathematical model is abstract by definition and is applied by taking into account specific tasks and criteria. Since the tasks of the administration differ depending on the region and country, the choice of criteria is set individually.

Conclusions: During the period of isolation, the volume of services in the Hotel - Restaurant- Catering/Café (HORECA) segment has decreased, and personnel has also been lost. The reduced pressure on public infrastructure and the departure of migrants means that, in the long term, this work cannot be restored within a short period of time.
Aristolochic acid nephropathy - still real danger
Authors: Oleszczuk Rafał , Grzebalska Agnieszka M. , Kozińska Iga , Orczykowski Maciej , Oleszczuk Anna
Published: October 2022

Arystolocholic acid nephropathy is chronic kidney disease caused by the use of substances of natural origin that contain arystolocholic acid. The effects of their use are arystolochic acid nephropathies, which include "Chinese Herbs" nephropathy. The course of the disease is very fast, resulting in progression to end-stage renal disease, and in the future it results in the development of urinary tract cancer. That is why it is so important to recognize it early and start treatment. However, due to disease progression, some patients require dialysis and even kidney transplantation. Although the World Health Organization is trying to stop the spread of the use of harmful substances, there are still reports of this nephropathy appearing in some populations. Despite warnings from the Food and Drug Administration regarding the safety of botanicals containing arystolochic acid and its classification as a human carcinogen, products containing it are still available for purchase online. The purpose of the literature review below is to analyze the latest knowledge on aristolochic acid nephropathy and its associated complication.
COST AND BENEFIT OF SHM IN COMMERCIAL AVIATION
Authors: STEINWEG DOMINIK , HORNUNG MIRKO
Published: October 2022

An integrated techno-economic cost-benefit analysis is presented to analyze the impact of damage detection-based SHM on an Airbus A320-based reference aircraft, instrumented with ultrasonic and fiber-optic sensors. The operational performance of aircraft with and without SHM is compared in terms of inspection effort, dispatch reliability, payload capacity, service limit, SHM equipment weight and performance, as well as total operating cost. Finally, the net present value of SHM is calculated. While SHM can be profitable for airlines, the achievable benefit depends on the SHM system performance and the economic environment of the airline.
VIBRATION-BASED STRUCTURAL HEALTH MONITORING OF DELIVERY DRONES: ANALYSIS OF PRELIMINARY EXPERIMENTS
Authors: IBRAHIM CHRISTINE-OMEIRA , SIMON JONAS , T FOX LENNART , MOLL JOCHEN , SCHÜTZ MARK-FELIX
Published: October 2022

The development of unmanned aerial vehicles (UAV) has progressed very rapidly in recent years and finds many applications in various industrial fields. The technological progress brings serious challenges, especially regarding flight safety, as any unexpected behavior of the drone can lead to serious consequences. The autonomous usage of delivery drones requires a high reliability especially in urban areas. This motivates the development and application of structural health monitoring (SHM) systems. In this work, we present and discuss the results of preliminary experiments of a vibration-based SHM system for delivery drones. In particular, we focus on the hover phase during take-off in which the airworthiness can be assessed within seconds. For this purpose, the drone is first launched and a measurement is made using acceleration sensors. The measurement data is evaluated using three different metrics one of which is the Nullspace-Based Fault Detection (NSFD) method. It was demonstrated here that added masses can be detected through the analysis of mechanical vibrations.
A BUSINESS INTELLIGENCE APPROACH TO PRIORITIZE BRIDGE MAINTENANCE ACTIVITIES
Authors: ORTIZ GIANNINA , GARITA CESAR
Published: October 2022

Given the general condition of road infrastructure in Costa Rica, the proper prioritization of maintenance activities for bridges is essential for government institutions to effectively plan and assign resource investments. This work presents the main results of an extension project developed by the e-Bridge program of the Costa Rica Institute of Technology, with the objective of designing and applying a methodology for prioritizing maintenance activities for bridges, taking as a case study the actual bridges managed by a specific regional municipality. To this end, first, a given set of bridges were inspected and evaluated. Then, with this detailed inventory information, a set of key bridge performance indicators were defined including structural condition, environmental variables, and socio-economical categories. Consequently, a tailor-made methodology was proposed to prioritize different kinds of maintenance activities for the respective bridges using the above-mentioned indicators. The methodology was implemented using a business intelligence tool to manage all the information and solve prioritization queries. This tool and the major findings of the project were shared during the project with community actors and municipality collaborators through several workshops. The resulting methodology and developed tool effectively support decision-making regarding bridge maintenance activities for the target municipality and could be applied nation-wide.
Frontiers: Framing Price Increase as Discount: A New Manipulation of Reference Price
Authors: Park Sungsik , Xie Man , Xie Jinhong
Published: October 2022

This paper investigates a newly observed pricing practice by which a seller frames a price premium as a discount by simultaneously increasing the price and introducing a list price.
October 2022 Medical Image of the Month: Infected Dasatinib Induced Chylothorax-The First Reported Case
Authors:   Wexford General Hospital, Wexford, Ireland, Mohammed Mortada , Abdelrahim Mohanad , Sharma Keshav
Published: October 2022

No abstract available. Manuscript truncated after 150 words. A 45-year-old man with chronic myeloid leukaemia (CML) on dasatinib presented to the emergency department with a 2-week history of dry cough, worsening shortness of breath and left-sided chest pain that had worsened on the day of presentation. On examination, oxygen saturation was 98% on 2 L nasal cannula, respiratory rate 22 bpm, pulse 77 bpm, blood pressure 117/90 mmHg and his temperature was 37.9° C (100.2 F). Examination of the left chest showed no air entry and stony dull percussion note. Laboratory results were significant for leucocytosis with a neutrophil count of 11.2, elevated CRP of 414, mildly elevated lactate of 1.1. Initial chest X-ray showed large left-sided pleural effusion and a small volume right effusion (Figure 1A). The patient was started on IV piperacillin /tazobactam, blood cultures were obtained and the dasatinib was held. Ultrasound-guided left thoracentesis and drain placement was performed, on ultrasound the effusion demonstrated several …
Impact of emotional labour on taking charge to predict employee’s creative and task performance: The moderation of performance-based pay from the lens of self-determination theory
Authors: Kumar Nilesh , Liu Zhiqiang , Flinchbaugh Carol , Hossain Md. Yahin , Hossain Md. Nahin
Published: October 2022

The importance of emotional labouring and performance of frontline service employees, who in their boundary-spanning positions significantly affect service-rendering organisations’ efficiency by their direct communications with customers, continues to increase. However, it is still important to ascertain an efficient understanding of the comprehensive process including behavioural mechanism and a common perception of the rewards’ impacts on motivation and creativity. Therefore, guided by self-determination theory, this study examined the mechanism and boundary conditions between emotional labour and job performance (creative and task)–specifically, taking charge has been considered as a mediator and performance-based pay as a moderator in between relationships. The authors selected a time-lagged cross-sectional design to investigate interrelations amongst study variables at two different time points and surveyed 417 team members and 186 team leaders in Pakistan’s commercial banks. Findings were consistent with the assumed conceptual framework. For instance, deep-acting affected taking charge positively, surface-acting demonstrated a positive link with task performance and taking charge partially mediated the relationships between deep-acting and performances under boundary conditions of low performance-based pay. By summing up, the study adds to the literature and recommends managerial implications with a more affluent view of nomothetic linkage among frontline employees’ emotional labor, HR practices, and the service sector.
Evaluation of patients’ satisfaction with bronchoscopy procedure
Authors: Karewicz Aleksandra , Faber Katarzyna , Karon Katarzyna , Januszewska Katarzyna , Ryl Joanna , Korczynski Piotr , Gorska Katarzyna , Dabrowska Marta , Krenke Rafal
Published: October 2022

Background

The bronchoscopy (BS) experience provokes anxiety amongst some patients. It can have a negative impact on the course of the procedure and on the willingness of patients to undergo the next BS in the future.

Objective

We aimed to identify factors influencing patients’ satisfaction with BS.

Methods

The prospective study had been conducted between January and June 2019. It included patients hospitalized in our Department, who underwent elective BS. Patients assessed their anxiety and satisfaction level before and after BS using the Visual Analogue Scale (VAS). Data concerning the course of the bronchoscopy was collected.

Results

The median level of anxiety prior to the procedure was moderate, higher in women (p<0.0001). The majority of patients (116/125, 93%) were satisfied with appropriate information before the procedure. Almost one-third of the interviewees (39/125, 31%) declared complete satisfaction (VAS = 0) with their procedure, 17 patients (14%) were dissatisfied (VAS >5/10). Overall 113 (90%) patients declared unconditional consent for future bronchoscopy. Multivariate linear regression analysis revealed two factors affecting patients’ satisfaction with bronchoscopy: anxiety prior to BS (standardized regression coefficient β = 0.264, p = 0.003) and discomfort (β = 0.205, p = 0.018). Neither age, degree of amnesia, duration of the procedure nor its type added any significant value as factors affecting patient satisfaction. The most common factors inducing patients’ discomfort during BS were local anesthesia of the throat (56/125, 45%) and cough (47/125, 38%).

Conclusions

Low anxiety level before bronchoscopy and reduced discomfort during the procedure are associated with better patient satisfaction. Thus, it is important to reduce patient anxiety and discomfort during the procedure.
“University students’ economic situation during the COVID-19 pandemic: A cross-sectional study in Germany”
Authors: Gewalt Sandra Claudia , Berger Sarah , Krisam Regina , Krisam Johannes , Breuer Markus
Published: October 2022

The COVID-19 pandemic caused a major economic downturn that disproportionally affected university students. This empirical research investigated effects and risk factors of the pandemic on students’ economic situation with focus on financial distress and financial limitations. Data was collected using an online survey in May and June 2020 from students (n = 917) enrolled at universities in Germany. 80.6% were enrolled in bachelor programs (n = 738), the mean semester was 3.8 (standard deviation (SD = 2.0) and students’ mean age was 23.1 years (SD = 4.1). 51.8% (n = 472) were female and 47.4% (n = 432) male. 56.7% (n = 506) of students worked before the pandemic. More than one third reported a decrease in income (36.5%; n = 334) and an increase in financial constraints (38.7%; n = 354). A multivariate logistic regression analysis showed that students with regular income were less likely to experience financial distress compared to those without (odds ratio (OR) = 0.456; p = 0.014). Furthermore, working part-time as associated with a higher financial distress compared to those without part-time employment (OR = 1.811; p = 0.003). Students who worked part-time before the pandemic also had a higher probability of increased financial restriction (or constraint) compared to those who did not work part-time (OR = 2.094; p < 0.001). University students were disproportionally affected by the economic consequences of the COVID-19 pandemic, which increased students’ economic uncertainty. To offset such problems, financial aid schemes for students need to be made available to alleviate distress and to allow students to focus on their studies but should not compound problems by leading to financial hardship at a later point in time.
A novel deep learning-assisted hybrid network for plasmodium falciparum parasite mitochondrial proteins classification
Authors: Alsanousi Wafa Alameen , Ahmed Nosiba Yousif , Hamid Eman Mohammed , Elbashir Murtada K. , Musa Mohamed Elhafiz M. , Wang Jianxin , Khan Noman , Afnan
Published: October 2022

Plasmodium falciparum is a parasitic protozoan that can cause malaria, which is a deadly disease. Therefore, the accurate identification of malaria parasite mitochondrial proteins is essential for understanding their functions and identifying novel drug targets. For classifying protein sequences, several adaptive statistical techniques have been devised. Despite significant gains, prediction performance is still constrained by the lack of appropriate feature descriptors and learning strategies in current systems. Moreover, good ground truth data is important for Artificial Intelligence (AI)-based models but there is a lack of that data in the literature. Therefore, in this work, we propose a novel hybrid network that combines 1D Convolutional Neural Network (CNN) and Bidirectional Gated Recurrent Unit (BGRU) to classify the malaria parasite mitochondrial proteins. Furthermore, we curate a sequential data that are collected from National Center for Biotechnology Information (NCBI) and UniProtKB/Swiss-Prot proteins databanks to prepare a dataset that can be used by the research community for AI-based algorithms evaluation. We obtain 4204 cases after preprocessing of the collected data and denote this set of proteins as PF4204. Finally, we conduct an ablation study on several conventional and deep models using PF4204 and the benchmark PF2095 datasets. The proposed model ‘CNN-BGRU’ obtains the accuracy values of 0.9096 and 0.9857 on PF4204 and PF2095 datasets, respectively. In addition, the CNN-BGRU is compared with state-of-the-arts, where the results illustrate that it can extract robust features and identify proteins accurately.
Limited value of neutrophil-to-lymphocyte ratio and serum creatinine as point-of-care biomarkers of disease severity and infection mortality in patients hospitalized with COVID-19
Authors: Tufa Abdisa , Gebremariam Tewodros Haile , Manyazewal Tsegahun , Asrat Yidnekachew , Getinet Tewodros , Hundie Tsegaye Gebreyes , Webb Dominic-Luc , Hellström Per M. , Genet Solomon
Published: October 2022

Introduction

In hospitalized COVID-19, neutrophil-to-lymphocyte ratio (NLR) and serum creatinine is sometimes measured under assumption they predict disease severity and mortality. We determined the potential value of NLR and serum creatinine as predictors of disease severity and mortality in COVID-19.

Methods

Prospective cohort study of COVID-19 patients admitted to premier COVID-19 treatment hospitals in Ethiopia. Predictive capability of biomarkers in progression and prognosis of COVID-19 was analyzed using receiver operating characteristics. Survival of COVID-19 patients with different biomarker levels was computed. Logistic regression assessed associations between disease severity and mortality on NLR and serum creatinine adjusted for odds ratio (AOR).

Results

The study enrolled 126 adults with severe (n = 68) or mild/moderate (n = 58) COVID-19, with median age 50 [interquartile range (IQR 20–86)]; 57.1% males. The NLR value was significantly higher in severe cases [6.68 (IQR 3.03–12.21)] compared to the mild/moderate [3.23 (IQR 2.09–5.39)], with the NLR value markedly associated with disease severity (p<0.001). Mortality was higher in severe cases [13 (19.1%)] compared to mild/moderate cases [2 (3.4%)] (p = 0.007). The NLR value was significantly higher in non-survivors [15.17 (IQR 5.13–22.5)] compared to survivors [4.26 (IQR 2.40–7.90)] (p = 0.002). Serum creatinine was significantly elevated in severe cases [34 (50%)] compared with mild/moderate [11 (19%)] (p<0.001). Disease severity [AOR 6.58, 95%CI (1.29–33.56),p = 0.023] and NLR [AOR 1.07, 95%CI (1.02–1.12),p = 0.004)] might be associated with death. NLR had a sensitivity and specificity of 69.1% and 60.3% as predictor of disease severity (cut-off >4.08), and 86.7% and 55.9% as prognostic marker of mortality (cut-off >4.63).

Conclusion

In COVID-19, NLR is a biomarker with only modest accuracy for predicting disease severity and mortality. Still, patients with NLR >4.63 are more likely to die. Monitoring of this biomarker at the earliest stage of the disease may predict outcome. Additionally, high creatinine seems related to disease severity and mortality.
The patterns of uveitis and the factors affecting visual outcome from Chulalongkorn University Uveitis Cohort (CU2C): A 5-year longitudinal study protocol
Authors: Juhong Jakkrit , Pongpirul Krit , Ueathaweephol Somtaporn , Somkijrungroj Thanapong , Kongwattananon Wijak
Published: October 2022

Background

In Thailand, several novel laboratory investigations are recently available to help differentiate the uveitic etiologies. The update on uveitis epidemiological data in Thailand is necessary to better understand the disease burden and provide guidance on management. The current study aims to describe the prevalence and identify factors associated with poor visual outcomes of uveitis patients at a tertiary center in Thailand.

Methods

A 5-year-prospective study of uveitis cases presented at a tertiary referral center in the central region of Thailand is conducted.