bluuebunny/crossref_metadata_2025 huggingface dataset:
Organizational presence and place: Sociomaterial place work in the Swedish outdoor industry
Authors: Crevani Lucia
Published: May 2019

The purpose of this article is to explore the relation between organizational presence and the place in which such a presence is enacted. To this end I mobilize Doreen Massey’s processual conceptualization of place as an event consisting of a bundle of trajectories. By following the presentification of a Swedish company, Fjällräven, in the natural environment in the North of Sweden during Fjällräven Classic, I show that the organization is not made present in place, but through place production. I propose the concept of place work to express the work done by representatives of the organization, but also by other humans and nonhumans, to make the throwntogetherness of the place result in a rather coherent and stable construction through which the organization is made present. Place work is therefore work through which organizational presence and place are recursively co-creating. The concept of place work expands what we can learn about the “where” of an organization when building on an ontology of performativity.
Unmasking work-family balance barriers and strategies among working fathers in the workplace
Authors: Tanquerel Sabrina , Grau-Grau Marc
Published: May 2019

This article explores the barriers and strategies experienced by Spanish working fathers regarding work-family balance. Based on 29 in-depth interviews with Spanish working fathers in different types of organizations and sectors, the results of this study present different barriers that are divided into three groups: contextual barriers, organizational barriers and internalized barriers. The results also suggest that the study’s participants fall into three categories or patterns: hegemonic gender order conformers, borderers and deviants, who use three different strategies (no strategies, invisible strategies and visible strategies) to overcome the barriers detected in this research. The dynamics of reinforcing, being complicit and challenging hegemonic masculinities within the workplace are discussed in light of recent theories regarding gender and organizations, masculinities and fatherhood.
Parent/caregiver perspectives of functioning in autism spectrum disorders: A comparative study in Sweden and South Africa
Authors: Viljoen Marisa , Mahdi Soheil , Griessel David , Bölte Sven , de Vries Petrus J
Published: May 2019

Functional outcomes in autism spectrum disorder can be highly variable given the heterogeneous nature of autism spectrum disorder and its interaction with environmental factors. We set out to compare parent/caregiver perceptions of functioning in two divergent countries that participated in the International Classification of Functioning Disability and Health (ICF) Core Set for Autism Spectrum Disorder development study. We focused on the frequency and content of items reported, and hypothesized that environmental factors would most frequently be reported as barriers to functioning in low-resource settings. Using frequency and qualitative content analysis, we compared data from South Africa ( n = 22) and Sweden ( n = 13). Frequency agreement was seen in three activities and participation categories, and one environmental factor. Obvious frequency differences were observed in one environmental factors category, six body functions categories and three activities and participation categories. Only three ICF categories (immediate family, attention functions, products and technology for personal use) differed in content. Contrary to our hypotheses, few differences in perspectives about environmental factors emerged. The universality of our findings supports the global usefulness of the recently developed ICF Core Sets for Autism Spectrum Disorder. We recommend that more comparative studies on autism spectrum disorder and functioning should be conducted, and that similar comparisons in other disorders where Core Sets have been developed may be valuable.
Mum’s the word: Public testimonials and gendered experiences of negotiating caring responsibilities with work in the film and television industries
Authors: Berridge Susan
Published: May 2019

This article explores parents’ published accounts of their (gendered) experiences of reconciling caring responsibilities with work in the film and television industries, paying particular attention to mothers. It is based on detailed analysis of the testimonials of parents who work in the sector, produced for and published on the website of UK activist organisation, Raising Films. As Wing-Fai et al. argue, the new labouring subjectivities produced and demanded by media industries’ working cultures are antithetical to those with caring responsibilities, in turn creating a climate in which the challenges of care are silenced. Recent reports and initiatives have sought to challenge this silencing, employing quantitative methodologies to identify the number of parents working in film and television who are affected by duties of care. What has been less attended to is the way in which these negotiations make cultural workers feel, and more specifically, the gendered dimensions of these inequalities. This article addresses this gap by offering a detailed analysis of the testimonials of mothers published on the website. I argue that women’s testimonials contribute to challenging the silencing around issues of care in the sector. While at times women reinforce new labouring subjectivities that privilege self-regulation, they simultaneously critique the punishing nature of neoliberal working cultures, commonly reflecting on the industries’ demand to suppress the challenges of care. These critiques are rarely framed as resistance to explicit gender inequalities. However, I argue that the testimonials’ presentation – published collectively and alongside one another on the site – allows for recurring experiential patterns to emerge that make it difficult to see these accounts as an individual woman’s problem and, importantly, highlight the specific gendered dimensions of the emotional violence of neoliberal labouring practices.
Dynamic damage assessment of float glass under blast loading
Authors: Zhou Xiao-Qing , Wang Ming-Yu , Li Li-Xiao
Published: May 2019

Architectural glass, especially the float glass, is a fragile part of a building. The architectural glass becomes a large amount of high-speed flying debris under bomb attacks and accidental explosions, thereby causing serious threat to residents. This study investigates the dynamic responses of a normal float glass subjected to blast loading using the explicit dynamic finite element software LS-DYNA. A JH-2 material model, which considers the strain rate effect and damage accumulation, is adopted for the float glass. A preliminary study shows that the present numerical model combined with reasonable material parameters can simulate the failure mode of the glass and the ejection velocity of glass fragments after failure. The verified model is then used to investigate the dynamic damage responses of the float glass under different loading cases. The damage assessment criterion of float glass is established on the basis of the glazing protection levels defined by the General Services Administration of the United States. Comprehensive simulations are conducted on different amounts of explosive and standoff distances. The degrees of glass damage under different loading cases are determined by combining the projection velocity of glass fragments after failure with a kinematic equation. Finally, the damage assessment diagram of float glass under different amounts of explosive is presented and compared with those in FEMA 426.
Clustering halal food consumers: A Twitter sentiment analysis
Authors: Mostafa Mohamed M.
Published: May 2019

The exponential growth of user-generated social media content raises the possibility of using opinion mining techniques in tracking and monitoring consumers’ preferences. Although the web represents a valuable data mining source about consumers’ opinions, no previous studies have investigated halal food sentiments expressed on social media. In this study, we fill this research gap by analyzing a random sample of 3,919 halal food tweets. A 6,800 seed adjectives expert-predefined lexicon was used to conduct the analysis. A generally positive sentiment toward halal food was detected through descriptive statistical analysis, whereas partitioning around medoids (PAM) clustering indicated that it is possible to cluster halal food consumers into four distinct segments. Thus, it seems that halal food consumers represent a highly heterogeneous group, divisible by level of religiosity, self-identity, animal welfare attitudes, and concern for food authenticity.
The utility of joint use of the Low Self-Control Scale and the Brief Self-Control Scale in explaining adolescent deviance
Authors: Li Jian-Bin , Vazsonyi Alexander T.
Published: May 2019

According to the general theory of crime, low self-control is the main cause of deviance. How to assess self-control is crucial because examination of the general theory of crime and assessment of adolescent risk of committing deviance relies on self-control measures. This study aims to examine whether two well-known cognitive scales of self-control, namely Grasmick et al.’s Low Self-Control Scale (LSCS) and Tangney et al.’s Brief Self-Control Scale (BSCS), explain unique, shared, and addictive variance in deviance in a sample of Czech adolescents ( N = 631). The results support that the two scales, when operated as total scores, explained both unique and shared variance in deviance and that joint use of the two scales explained more variance in deviance. In addition, when the LSCS was operated as components, some components were more able than other components to explain deviance. Similarly, each component and the BSCS, when used together, explained unique, shared, and addictive variance in deviance. Theoretical and practical implications are discussed.
Pre-diabetes mellitus newly diagnosed after myocardial infarction adversely affects prognosis in patients without known diabetes
Authors: Chattopadhyay Sudipta , George Anish , John Joseph , Sathyapalan Thozhukat
Published: May 2019

Background:

Effect of pre-diabetes mellitus on post-myocardial infarction prognosis is unclear.

Methods:

Retrospective cohort analysis of 1056 myocardial infarction survivors with fasting plasma glucose and 2-h post-load plasma glucose measured. Major adverse cardiovascular events included death, non-fatal reinfarction and ischaemic stroke. Cox proportional hazard regression identified predictors of event-free survival. Continuous net reclassification improvement and integrated discrimination improvement determined the added predictive value of glycaemic indices.

Results:

Major adverse cardiovascular events occurred in 25.1% and 16.4% patients with and without pre-diabetes mellitus (hazard ratio with pre-diabetes mellitus: 1.56; 95% confidence interval: 1.17–2.08; p = 0.003) in the whole cohort and in 24.1% and 17.2% patients (hazard ratio with pre-diabetes mellitus, 1.43; 95% confidence interval: 1.03–1.98; p = 0.033) in the matched cohort, respectively. Pre-diabetes mellitus predicted major adverse cardiovascular events–free survival in whole (hazard ratio: 1.39; 95% confidence interval: 1.03–1.89; p = 0.033) and matched cohorts (hazard ratio: 1.42; 95% confidence interval: 1.01–1.99; p = 0.043). The 2-h post-load plasma glucose, but not fasting plasma glucose, predicted major adverse cardiovascular events–free survival in the whole (hazard ratio: 1.16; 95% confidence interval: 1.07–1.26; p < 0.0001) and matched cohorts (hazard ratio: 1.20; 95% confidence interval: 1.09–1.31; p < 0.0001). Adding 2-h post-load plasma glucose to models containing fasting plasma glucose, significantly improved net reclassification improvement and integrated discrimination improvement for both cohorts, but not vice versa.

Conclusion:

Pre-diabetes mellitus predicts major adverse cardiovascular events after myocardial infarction. The 2-h post-load plasma glucose predicts prognosis better than fasting plasma glucose in these patients.
Immuno-PET Imaging of the Programmed Cell Death-1 Ligand (PD-L1) Using a Zirconium-89 Labeled Therapeutic Antibody, Avelumab
Authors: Jagoda Elaine M. , Vasalatiy Olga , Basuli Falguni , Opina Ana Christina L. , Williams Mark R. , Wong Karen , Lane Kelly C. , Adler Steve , Ton Anita Thein , Szajek Lawrence P. , Xu Biying , Butcher Donna , Edmondson Elijah F. , Swenson Rolf E. , Greiner John , Gulley James , Eary Janet , Choyke Peter L.
Published: May 2019

Objective:

The goal is to evaluate avelumab, an anti-PD-L1 monoclonal immunoglobulin G antibody labeled with zirconium-89 in human PD-L1-expressing cancer cells and mouse xenografts for clinical translation.

Methods:

[89Zr]Zr-DFO-PD-L1 monoclonal antibody (mAb) was synthesized using avelumab conjugated to desferrioxamine. In vitro binding studies and biodistribution studies were performed with PD-L1+MDA-MB231 cells and MDA-MB231 xenograft mouse models, respectively. Biodistributions were determined at 1, 2, 3, 5, and 7 days post coinjection of [89Zr]Zr-DFO-PD-L1 mAb without or with unlabeled avelumab (10, 20, 40, and 400 µg).

Results:

[89Zr]Zr-DFO-PD-L1 mAb exhibited high affinity (Kd ∼ 0.3 nM) and detected moderate PD-L1 expression levels in MDA-MB231 cells. The spleen and lymph nodes exhibited the highest [89Zr]Zr-DFO-PD-L1 mAb uptakes in all time points, while MDA-MB231 tumor uptakes were lower but highly retained. In the unlabeled avelumab dose escalation studies, spleen tissue–muscle ratios decreased in a dose-dependent manner indicating specific [89Zr]Zr-DFO-PD-L1 mAb binding to PD-L1. In contrast, lymph node and tumor tissue–muscle ratios increased 4- to 5-fold at 20 and 40 µg avelumab doses.

Conclusions:

[89Zr]Zr-DFO-PD-L1 mAb exhibited specific and high affinity for PD-L1 in vitro and had target tissue uptakes correlating with PD-L1 expression levels in vivo. [89Zr]Zr-DFO-PD-L1 mAb uptake in PD-L1+tumors increased with escalating doses of avelumab.
Sensory Outcomes in Digital Nerve Repair Techniques: An Updated Meta-analysis and Systematic Review
Authors: Herman Zachary J. , Ilyas Asif M.
Published: May 2019

Background: Injuries to digital nerves are common with trauma to the hand, often requiring surgery. Surgical management of these injuries can be performed using several techniques: direct repair (neurorrhaphy), autograft, allograft, and conduit repair. In light of increasing the availability and use of various digital nerve repair techniques, a new systematic review and meta-analysis was undertaken to comparatively review the available evidence to determine any differences in outcomes to better guide treatment in cases with digital nerve gaps. Methods: Current literature on sensory outcomes of various digital nerve repair techniques was reviewed using static 2-point discrimination (S2PD), moving 2-point discrimination (M2PD), Semmes-Weinstein monofilament testing (SWMF), and complication rates as outcomes of interest. After inclusion and exclusion criteria were applied, 15 articles were reviewed and 625 nerve repairs were analyzed. Results: The average gap length for allograft repair, autograft repair, and conduit repair was 15.4, 24.7, and 13.4 mm, respectively. For S2PD outcomes, autograft repair was statistically superior to all other forms of repair. Allograft trended higher than neurorrhaphy and conduit repair, but results were not statistically significant. For SWMF outcomes, autograft repair was statistically superior to conduit repair and neurorrhaphy; it was statistically comparable with allograft repair. Allograft performed statistically superior to conduit repair relative to M2PD. Conclusions: Based on the current updated meta-analysis using newer data and techniques, we found that all available techniques have reasonable outcomes. Yet when managing a digital nerve injury with a gap, thereby excluding direct neurorrhaphy, both autograft and allograft performed comparably and were superior to conduit repair.
From tweets to graffiti: ‘I am Charlie’ as a ‘writing event’
Authors: Bazin Maëlle
Published: May 2019

Any visitor who walked the streets of Paris in the days or weeks following the attacks of January 2015 would definitely have witnessed a particular form of graphic irruption: the dissemination of messages of solidarity and mourning, and the repetition, within this mass of writing, of the formula ‘I am Charlie’. Although the situation was different, the responses to terrorist attacks in January 2015 and the 9/11 aftermath are comparable by the ‘writing event’ (Fraenkel, 2002, 2018) they produced: temporary and atypical dispositifs of writing turned to the public space in order to be read or at least seen by passers-by. This article, structured along chronological lines, traces the evolution of the viral formula over the long term from Twitter to the urban public space. Firstly, the author focuses on the origin and meanings of the statement and formulates several hypotheses that may explain its wide circulation on social networks. Secondly, she analyses the post-attack graffiti based on databases of several private graffiti-cleaning companies in order to highlight the temporary sacralization of illegal writings. The ‘ Je suis Charlie’ phenomenon is interesting in many ways: its staggering, massive diffusion; the apparent unanimity with which it was greeted in the world of politics and the media; and the way it was managed by local authorities.
Appropriate use of antibiotics: an unmet need
Authors: López Romo Alicia , Quirós Rodolfo
Published: May 2019

Increasing bacterial resistance combined with a steady decline in the discovery of new antibiotics has resulted in a global healthcare crisis. Overuse of antibiotics, for example, in the poultry and cattle industry, and misuse and improper prescription of antibiotics are leading causes of multidrug resistance (MDR). The increasing use of antibiotics, particularly in developing countries, is a big concern for antibiotic resistance and can cause other health threats such as increased risk of recurrent infections and increased risk of cardiovascular death with chronic use of macrolides. Carbapenems are the last line of defense in many cases of resistant infection, but trends show that resistance against these agents is also increasing. This narrative review is based on relevant literature according to the experience and expertise of the authors and presents an overview of the current knowledge on antibiotic resistance, the key driving factors, and possible strategies to tackle antibiotic resistance. Collectively, studies show that hospital-wide antibiotic stewardship programs are effective in decreasing the spread of antibacterial resistance. As resistance varies according to local patterns of use, it is essential to observe the epidemiology at both a regional and an institutional level. Furthermore, adaptation of clinical guidelines is necessary, particularly for inpatient care. Future guidelines should include a justification step for continued treatment of antibiotic treatments and criteria for selection of antibiotics at the start of treatment. Nonantibiotic prevention strategies can limit infections and should also be considered in treatment plans. Vaccines against MDR organisms have shown some efficacy in phase II trials in critical care patients. Nonimmunogenic and microbiologic treatment options such as fecal transplants may be particularly important for elderly and immune-compromised patients.
A monolithic algorithm for the flow simulation of flexible flapping wings
Authors: Yang Tao , Wei Mingjun , Jia Kun , Chen James
Published: May 2019

It has been a challenge to simulate flexible flapping wings or other three-dimensional problems involving strong fluid–structure interactions. Solving a unified fluid–solid system in a monolithic manner improves both numerical stability and efficiency. The current algorithm considered a three-dimensional extension of an earlier work which formulated two-dimensional fluid–structure interaction monolithically under a unified framework for both fluids and solids. As the approach is extended from a two-dimensional to a three-dimensional configuration, a cell division technique and the associated projection process become necessary and are illustrated here. Two benchmark cases, a floppy viscoelastic particle in shear flow and a flow passing a rigid sphere, are simulated for validation. Finally, the three-dimensional monolithic algorithm is applied to study a micro-air vehicle with flexible flapping wings in a forward flight at different angles of attack. The simulation shows the impact from the angle of attack on wing deformation, wake vortex structures, and the overall aerodynamic performance.
Importance of coding co-morbidities for APR-DRG assignment: Focus on cardiovascular and respiratory diseases
Authors: Souza Julio , Santos João Vasco , Canedo Veronica Bolon , Betanzos Amparo , Alves Domingos , Freitas Alberto
Published: May 2019

Background:

The All Patient-Refined Diagnosis-Related Groups (APR-DRGs) system has adjusted the basic DRG structure by incorporating four severity of illness (SOI) levels, which are used for determining hospital payment. A comprehensive report of all relevant diagnoses, namely the patient’s underlying co-morbidities, is a key factor for ensuring that SOI determination will be adequate.

Objective:

In this study, we aimed to characterise the individual impact of co-morbidities on APR-DRG classification and hospital funding in the context of respiratory and cardiovascular diseases.

Methods:

Using 6 years of coded clinical data from a nationwide Portuguese inpatient database and support vector machine (SVM) models, we simulated and explored the APR-DRG classification to understand its response to individual removal of Charlson and Elixhauser co-morbidities. We also estimated the amount of hospital payments that could have been lost when co-morbidities are under-reported.

Results:

In our scenario, most Charlson and Elixhauser co-morbidities did considerably influence SOI determination but had little impact on base APR-DRG assignment. The degree of influence of each co-morbidity on SOI was, however, quite specific to the base APR-DRG. Under-coding of all studied co-morbidities led to losses in hospital payments. Furthermore, our results based on the SVM models were consistent with overall APR-DRG grouping logics.

Conclusion and implications:

Comprehensive reporting of pre-existing or newly acquired co-morbidities should be encouraged in hospitals as they have an important influence on SOI assignment and thus on hospital funding. Furthermore, we recommend that future guidelines to be used by medical coders should include specific rules concerning coding of co-morbidities.
Who Gossips and How in Everyday Life?
Authors: Robbins Megan L. , Karan Alexander
Published: May 2019

Although laypeople often view gossipers as immoral, uneducated, typically female, and of lower social class, no systematic observation has empirically revealed the characteristics of those who gossip more than others nor examined the characteristics of gossip across everyday contexts. We used data from five naturalistic observation studies ( N = 467) to examine who gossips and how. All participants wore the Electronically Activated Recorder (EAR), which acoustically sampled 5–12% over 2–5 days, and completed demographics and personality questionnaires. Sound files were coded for gossip, valence (positive, negative, and neutral), subject (acquaintance and celebrity), and topic (social information, physical appearance, and achievement). Frequent gossipers tended to be more extraverted. Women engaged in more neutral gossip than men, and younger people tended to negatively gossip more than older people. Gossip tended to be neutral, rather than positive or negative, and about social information. These naturalistic observation findings dispel some stereotypes about this prevalent yet misunderstood behavior.
A case report of therapeutically challenging chronic actinic dermatitis
Authors: Verma Luvneet , Pratt Melanie
Published: May 2019

Chronic actinic dermatitis is a difficult to treat photodermatitis. Treatment is not standardized and involves topical corticosteroids and immunomodulators, and systemic immunosuppressive agents. We present a case with partial response to dupilumab, a monoclonal antibody approved for atopic dermatitis. In recalcitrant cases, systemic agents such as methotrexate, azathioprine, mycophenolate mofetil, and thalidomide, extracorpeal electrophoresis, and low-dose psoralen and ultraviolet A can also be considered.
Clinical variants of limbic encephalitis
Authors: Schermann Haggai , Ponomareva Irina Victorovna , Maltsev Vasily Gennadievich , Yakushev Konstantin Borisovich , Sherman Mikhail Aizikovich
Published: May 2019

The clinical picture of immunomediator disorders of the central nervous system resulting from autoimmune or paraneoplastic processes is often represented by the limbic symptom complex or limbic encephalitis. The article gives a brief description of these conditions, allocated to a separate nosological group in 2007. The symptoms of limbic encephalitis include mental disorders and epileptic seizures of both convulsive and non-convulsive spectrum, up to epileptic status. Four clinical cases representative of different variants of limbic encephalitis are presented in this study, along with the discussion of epidemiology, differential diagnostics, and generally accepted patient management strategies. The diagnosis of limbic encephalitis was made on clinical grounds alone in three cases and on the presence of antibodies to N-Methyl-d-aspartic acid receptors in one case. A combination of glucocorticoid pulse therapy with prolonged use of valproic acid was successfully applied for the treatment of limbic encephalitis with non-convulsive epileptic status. Plasmapheresis was used for the treatment of limbic encephalitis with recurrent focal non-motor attacks with and without loss of consciousness, as well as for limbic encephalitis with focal motor attacks. Presented cases emphasize the need to increase the awareness of physicians of various specialties to autoimmune disorders of the nervous system. In addition, it highlights the necessity of complete diagnostic workup for a patient with impaired consciousness of unclear etiology.
Cognitive behavioural therapy for myalgic encephalomyelitis/chronic fatigue syndrome is not effective. Re-analysis of a Cochrane review
Authors: Vink Mark , Vink-Niese Alexandra
Published: May 2019

Analysis of the 2008 Cochrane review of cognitive behavioural therapy for chronic fatigue syndrome shows that seven patients with mild chronic fatigue syndrome need to be treated for one to report a small, short-lived subjective improvement of fatigue. This is not matched by an objective improvement of physical fitness or employment and illness benefit status. Most studies in the Cochrane review failed to report on safety or adverse reactions. Patient evidence suggests adverse outcomes in 20 per cent of cases. If a trial of a drug or surgical procedure uncovered a similar high rate, it would be unlikely to be accepted as safe. It is time to downgrade cognitive behavioural therapy to an adjunct support-level therapy, rather than a treatment for chronic fatigue syndrome.
Spontaneous Regression of Swollen Submandibular Glands in IgG4-Related Disease
Authors: Suzuki Masanobu , Nakamaru Yuji , Takagi Dai , Honma Aya , Suzuki Takayoshi , Takakuwa Emi , Morita Shinya , Vreugde Sarah , Homma Akihiro
Published: May 2019

Background

IgG4-related disease is a new clinical entity frequently associated with swelling of the submandibular glands (SMGs). The long-term outcome of SMG swelling without steroid therapy remains unknown.

Objective

To examine whether swollen SMGs spontaneously regress without steroid therapy in the context of IgG4-related disease and to identify biomarkers that can predict the spontaneous regression of SMG swelling.

Methods

The SMG volume of 49 patients diagnosed with IgG4-related disease was calculated by measuring the axial and coronal planes of computed tomography scans. The change in SMG volume over time was measured and examined by treatment regimen, clinical data, and serum complement level.

Results

We found 28 of 49 (57%) IgG4-related disease patients to have swollen SMGs, with 15 of 20 (75%) of the swollen SMGs regressing without steroid therapy. The time required for the SMGs swelling to regress was significantly shorter in the steroid therapy group than in the no-steroid therapy group. Serum complement components at the initial visit were significantly lower in the regressed SMG group than in the nonregressed SMG group.

Conclusion

We observed 75% of swollen SMGs spontaneously regressed in patients with IgG4-related disease. The time required for the swollen SMGs to regress was longer in patients without steroid therapy than in those with steroid therapy. Serum complement level could be used as a predictor for the spontaneous regression of swollen SMGs in patients with IgG4-related disease.
The Impact of Computers on Marking Behaviors and Assessment: A Many-Facet Rasch Measurement Analysis of Essays by EFL College Students
Authors: He Tung-hsien
Published: May 2019

This study employed a mixed-design approach and the Many-Facet Rasch Measurement (MFRM) framework to investigate whether rater bias occurred between the onscreen scoring (OSS) mode and the paper-based scoring (PBS) mode. Nine human raters analytically marked scanned scripts and paper scripts using a six-category (i.e., six-criterion) rating rubric. Interviews with these raters were then conducted to gather their reflections concerning the marking experiences in the two modes. Software program FACETS was employed to estimate raters’ scores, with the results indicating that (a) four raters marked the scanned scripts more severely than they did the paper scripts, whereas the remaining four raters exhibited an opposite tendency; (b) the only rater whose composite scores were comparable between the two modes still awarded harsher scores to the category of Mechanics in PBS mode; and (c) the category of Mechanics was scored more harshly in OSS mode, whereas Topic Development/Support was scored more severely in PBS mode. Analyses of quantitative and qualitative data indicated that computers affected raters’ marking behaviors and their assessment, assuming a role in causing scoring bias. Implications for rater training were provided.
Preoperative Assessment of the Feasibility of Pedicle Screw Insertion at the Proximal Thoracic Curve in Lenke Type 2 Idiopathic Scoliosis
Authors: Taniguchi Yuki , Matsubayashi Yoshitaka , Kato So , Ono Takashi , Oshima Yasushi , Tanaka Sakae
Published: May 2019

Study Design:

Retrospective cohort study.

Objectives:

To investigate the feasibility of inserting pedicle screws in the proximal thoracic (PT) curve in Lenke type 2 idiopathic scoliosis, using post-myelography computed tomography (CT).

Methods:

Post-myelography CT images of 46 Japanese patients, 10 to 30 years old, who underwent surgery for Lenke type 2 idiopathic scoliosis were analyzed. A new parameter “SAPS” (space available for pedicle screw) was introduced, which defines the minimal distance between the lateral cortex of the pedicle and the spinal cord, with a SAPS <4.5 mm being “unacceptable.” All 460 pedicles (T2 through T6) were analyzed. Pedicle diameter was classified according to the Akazawa grading system.

Results:

Most pedicles on the right side at T3 (84.8%) and T4 (97.8%) were unacceptable. The unacceptable rate was 58.7% and 15.2% on the right side at T5 and T6, respectively. A larger Cobb angle of the PT curve was associated with a greater incidence of unacceptable SAPS at these levels. For a Cobb angle of the PT curve >40°, most right T5 pedicles were unacceptable. On the left side, most pedicles from T2 to T5 were acceptable. When T5 was the caudal end vertebra of the PT curve, the left T6 pedicles had an unacceptable SAPS in some cases. When the width of the pedicle channel was ≥2 mm (Akazawa grade 1 or 2), all pedicles from T2 to T6, on both sides, were acceptable.

Conclusions:

Post-myelography CT enabled us to clearly demonstrate the feasibility of inserting pedicle screws in the PT region.
Structural Topic Modeling For Social Scientists: A Brief Case Study with Social Movement Studies Literature, 2005–2017
Authors: Lindstedt Nathan C.
Published: May 2019

Sociologists frequently make use of language as data in their research using methodologies including open-ended surveys, in-depth interviews, and content analyses. Unfortunately, the ability of researchers to analyze the growing amount of these data declines as the costs and time associated with the research process increases. Topic modeling is a computer-assisted technique that can help social scientists to address these data challenges. Despite the central role of language in sociological research, to date, the field has largely overlooked the promise of automated text analysis in favor of more familiar and more traditional methods. This article provides an overview of a topic modeling framework especially suited for social scientific research. By way of a case study using abstracts from social movement studies literature, a short tutorial from data preparation through data analysis is given for the method of structural topic modeling. This example demonstrates how text analytics can be applied to research in sociology and encourages academics to consider such methods not merely as novel tools, but as useful supplements that can work beside and enhance existing methodologies.
Standardizing Biases: Selection Devices and the Quantification of Race
Authors: Hirschman Daniel , Bosk Emily Adlin
Published: May 2019

Racial inequality persists despite major advances in formal, legal equality. Scholars and policymakers argue that individual biases (both explicit and implicit) combine with subjective organizational decision-making practices to perpetuate racial inequality. The standardization of decision making offers a potential solution, promising to eliminate the subjectivity that biases consequential decisions. We ask, under what conditions may standardization reduce racial inequality? Drawing on research in science studies and law and society, we argue that standardization must be understood as a heterogeneous practice capable of producing very different outcomes depending on the details of the standard and the organizational infrastructure surrounding its use. We compare selection devices—simple quantified tools for making allocation decisions—in undergraduate admissions and child welfare to highlight the complex relationships between race and standardization. Child welfare agencies adopted a colorblind actuarial device that attempted to predict which children were most at risk and then make decisions based on those predictions. In contrast, the University of Michigan’s points system explicitly considered and valued race, with the goal of increasing minority student enrollments in the context of promoting student body diversity. Comparing these cases demonstrates how actuarial standardization practices, including those adopted with the intention of reducing racial inequality, tend to reinforce an unequal status quo by ideologically reconfiguring mutable social structures into immutable individual risk factors. In contrast, nonactuarial practices that explicitly promote racial equality are vulnerable to political challenges as they violate norms of colorblindness and cannot be defended in terms of their predictive validity.
Parental Stress as a Child With Diabetes Transitions From Adolescence to Emerging Adulthood
Authors: Tomette Alisa , Henderson J. Neil , Hass Amanda , Carson Linda D. , King Kama
Published: May 2019

This study examined parental and caregiver distress among families caring for children with type 1 diabetes as the child transitions into Emerging Adulthood. More than 96 hours of semistructured interviews were conducted with 19 adult caregivers including parents, grandparents, and other adult family members of 10 children. Each research partner participated in multiple face-to-face, 1- to 1.5-hour long-evolving interviews over the course of 4.5 years. Paradoxically, caregivers were found to experience significant increase in distress as their child with diabetes entered the developmental stage of Emerging Adulthood, 18 to 25 years old, by which time they should be masters of self-care, and parental distress should begin to decline. This increase in familial distress was associated with the emerging adults leaving the home, being unable to maintain an acceptable level of self-care, and experiencing declining health, frequent visits to the emergency department, and repeated hospitalizations. These findings suggest that parental distress from caring for a child with diabetes continues as the child ages, matures, and transitions into adulthood and may be exacerbated when the emerging adult with type 1 diabetes leaves the home and the direct observation and care of the parent.
Understanding the Process of Procedural Sedation for Orthopedic Injuries in the Pediatric Emergency Department
Authors: Vukovic Adam A , Keiner Elizabeth , Hanson Holly R
Published: May 2019

Objective:

To establish a procedural sedation (PS) time line for patients in the pediatric emergency department (PED) with orthopedic injuries.

Methods:

Retrospective review of patients requiring PS for orthopedic injuries. Process times were collected. Ten percent of encounters were co-reviewed. Interrater reliability and descriptive statistics were calculated.

Results:

A total of 189 patients were included. Co-abstracted data demonstrated excellent agreement. The median time to PS and length of stay (LOS) were 214 (interquartile range [IQR]: 160-282) and 320 (IQR: 257-402) minutes, respectively.

Conclusion:

Patients with orthopedic injuries requiring PS experience prolonged PED visits. Interventions should target safely reducing the time to PS and LOS.
Young migrant mental health difficulties and suicidal behaviours: an alternative perspective
Authors: Petti Theodore A. , Chen Andrew
Published: May 2019

The Saving and Empowering Young Lives in Europe (SEYLE) study brings attention to the special needs of adolescent migrants. Alternative data analyses could lead to improved service delivery and requisite education/training of health and mental health personnel. We advocate earlier identification by using SEYLE data to shape policy about youth suicidal behaviour and ideation in prevention efforts.
Diffuse Large B-Cell Lymphoma in Kenya: MYC, BCL2, and the Cell of Origin
Authors: Wawire Jonathan , Sayed Shahin , Moloo Zahir , Sohani Aliyah R.
Published: May 2019

PURPOSE

Diffuse large B-cell lymphoma (DLBCL) is the most commonly diagnosed non-Hodgkin lymphoma in adults in Kenya. Cell of origin (COO) and double expression of MYC and BCL2 are two important prognostic factors for DLBCL. A small subset (5% to 10%) of DLBCL cases show positivity for CD5 and are associated with poor prognosis, whereas CD30 antigen, seen in up to 10% of cases, may be a useful target for therapy. We sought to determine the prevalence of MYC/BCL2 double expression, COO, and proportion of Epstein-Barr virus positivity among patients with DLBCL diagnosed at a tertiary referral laboratory in Kenya.

PATIENTS AND METHODS

All cases of DLBCL diagnosed from 2012 through 2015 in our pathology department were analyzed. Tumor tissue microarray sections were stained with CD20, CD3, CD5, CD30, BCL2, BCL6, CD10, MUM1, MYC, and Ki67, classified for COO on the basis of the Hans algorithm, and subjected to Epstein-Barr virus-encoded small RNAs in situ hybridization.

RESULTS

Among 165 DLBCL cases, the median age was 50 years, and there was no sex predilection. Only 18 (10.9%) cases showed double expression for MYC and BCL2. Germinal center B (GCB)-cell type DLBCL accounted for 67 cases (40.6%) and 97 cases (59.4%) were classified as non-GCB. The mean Ki67 proliferation index was significantly higher in the double-expressing (45%) and non-GCB groups (36%) compared with the non–double-expressing group (29%) and GCB group (26%). Sixteen cases (9.7%) were Epstein-Barr virus-encoded small RNAs positive, 12 (75%) of which were non-GCB.

CONCLUSION

DLBCL in Kenya is seen in much younger patients with the poor prognostic non–GCB-type accounting for 59.4% of cases. MYC and BCL2 double expression was seen in fewer tumors than reported in the literature and in significantly older patients.
Early Recognition of a Transient Ischemic Attack Utilizing Cerebral Oxygenation Monitoring During Shoulder Surgery in the Beach Chair Position: A Case Report
Authors: Aguirre José A. , Mohajeri Minou S. , Rupnik Barbara , Brada Muriel , Rosskopf Andrea B. , Meyer Dominik C. , Eichenberger Urs , Borgeat Alain
Published: May 2019

Shoulder surgery in the beach chair position is routinely performed, and central neurological events are rare but potentially devastating. We present a patient with transient neurological deficits after a sudden blood pressure drop with a simultaneous decrease of regional cerebral saturation values registered by cerebral oximetry. We reviewed published cases and proposed possible strategies to prevent the occurrence of similar complications in this context.
The origins and non-canonical functions of macrophages in development and regeneration
Authors: Theret Marine , Mounier Remi , Rossi Fabio
Published: May 2019

The discovery of new non-canonical (i.e. non-innate immune) functions of macrophages has been a recurring theme over the past 20 years. Indeed, it has emerged that macrophages can influence the development, homeostasis, maintenance and regeneration of many tissues and organs, including skeletal muscle, cardiac muscle, the brain and the liver, in part by acting directly on tissue-resident stem cells. In addition, macrophages play crucial roles in diseases such as obesity-associated diabetes or cancers. Increased knowledge of their regulatory roles within each tissue will therefore help us to better understand the full extent of their functions and could highlight new mechanisms modulating disease pathogenesis. In this Review, we discuss recent studies that have elucidated the developmental origins of various macrophage populations and summarize our knowledge of the non-canonical functions of macrophages in development, regeneration and tissue repair.
The Shh receptor Boc is important for myelin formation and repair
Authors: Zakaria Mary , Ferent Julien , Hristovska Ines , Laouarem Yousra , Zahaf Amina , Kassoussi Abdelmoumen , Mayeur Marie-Eve , Pascual Olivier , Charron Frederic , Traiffort Elisabeth
Published: May 2019

Myelination leads to the formation of myelin sheaths surrounding neuronal axons and is crucial for function, plasticity and repair of the central nervous system (CNS). It relies on the interaction of the axons and the oligodendrocytes: the glial cells producing CNS myelin. Here, we have investigated the role of a crucial component of the Sonic hedgehog (Shh) signalling pathway, the co-receptor Boc, in developmental and repairing myelination. During development, Boc mutant mice display a transient decrease in oligodendroglial cell density together with delayed myelination. Despite recovery of oligodendroglial cells at later stages, adult mutants still exhibit a lower production of myelin basic protein correlated with a significant decrease in the calibre of callosal axons and a reduced amount of the neurofilament NF-M. During myelin repair, the altered OPC differentiation observed in the mutant is reminiscent of the phenotype observed after blockade of Shh signalling. In addition, Boc mutant microglia/macrophages unexpectedly exhibit the apparent inability to transition from a highly to a faintly ramified morphology in vivo. Altogether, these results identify Boc as an important component of myelin formation and repair.
Trade, Migration, and Productivity: A Quantitative Analysis of China
Authors: Tombe Trevor , Zhu Xiaodong
Published: May 2019

We study how goods- and labor-market frictions affect aggregate labor productivity in China. Combining unique data with a general equilibrium model of internal and international trade, and migration across regions and sectors, we quantify the magnitude and consequences of trade and migration costs. The costs were high in 2000, but declined afterward. The decline accounts for 36 percent of the aggregate labor productivity growth between 2000 and 2005. Reductions in internal trade and migration costs are more important than reductions in external trade costs. Despite the decline, migration costs are still high and potential gains from further reform are large. (JEL E24, F16, J24, P23, P25, R12, R23)
Religion, Division of Labor, and Conflict: Anti-Semitism in Germany over 600 Years
Authors: Becker Sascha O. , Pascali Luigi
Published: May 2019

We study the role of economic incentives in shaping the coexistence of Jews, Catholics, and Protestants, using novel data from Germany for 1,000+ cities. The Catholic usury ban and higher literacy rates gave Jews a specific advantage in the moneylending sector. Following the Protestant Reformation (1517), the Jews lost these advantages in regions that became Protestant. We show (i) a change in the geography of anti-Semitism with persecutions of Jews and anti-Jewish publications becoming more common in Protestant areas relative to Catholic areas; (ii) a more pronounced change in cities where Jews had already established themselves as moneylenders. These findings are consistent with the interpretation that, following the Protestant Reformation, Jews living in Protestant regions were exposed to competition with the Christian majority, especially in moneylending, leading to an increase in anti-Semitism. (JEL D74, J15, N33, N43, N93)
Impact factors for safety, success, duration and radiation exposure in CT-guided interventions
Authors: Pradella Maurice , Trumm Christoph , Stieltjes Bram , Boll Daniel T , Zech Christoph J , Huegli Rolf W
Published: May 2019

Objective:

We aim to compare factors influencing safety, success rate and radiation dose of CT-guided biopsies and drainages in a non-teaching setting with experienced operators vs a teaching setting with residents.

Methods:

A total of 1021 cases were retrospectively analyzed regarding lesion size, distance from skin, procedure duration, radiation dose, complications and clinical success. Procedures were grouped into biopsies of lung, liver, (remaining) abdomen, musculoskeletal system (MSK) and drainages of any region. Procedures in non-teaching setting were performed by experienced operators (full time interventional radiology staff), teaching setting consisted of residents under supervision of interventional radiology staff.

Results:

Overall clinical success rate was 93.6 % [experienced (exp.) vs teaching setting: 93.5 and 93.6 %, p = 0.97]. Overall complication rate was 7.2% (5.7% minor, 1.6% major; exp. vs teaching: 8.0 and 6.5 %, p = 0.67]. Experienced operators performed chest and liver biopsies faster even though they were facing smaller lesions. Multiple regression analysis revealed that depth from skin significantly increased procedure duration by 36.8 s per cm (p < 0.001) and also radiation dose by 5.4 mGy per cm (p < 0.001) in all interventions. On average, teaching setting increased the duration of an intervention by 209.8 s and total radiation dose by 10.6 mGy (p < 0.001, p < 0.001 respectively).

Conclusion:

CT guided interventions can be performed safe und successful disregarding anatomical parameters or teaching setting. Depth from skin and teaching setting should be taken into account both from a clinical and a time-conscious point of view since they increase radiation dose and prolong operations.

Advances in knowledge:

This is the first study with >1000 interventions which shows and quantifies the impact of lesion depth and teaching setting in CT-guided interventions.