bluuebunny/crossref_metadata_2025 huggingface dataset:
Surgical treatment of large-volume benign prostate hyperplasia: a comparative analysis of the outcomes of using standard and modified laparoscopic retropubic simple prostatectomy combined with temporary clamping of the internal iliac arteries and vesicourethral anastomosis
Authors: Volkov S. N. , Pushkar D. Yu. , Kolontarev K. B. , Stepanchenko V. S. , Tereshchenko V. I. , Dzharimok A.  R. , Shevyakina A. E. , Daurov M. A.
Published: March 2024

Introduction. The optimal approaches to the surgical treatment of large-volume benign prostatic hyperplasia (BPH) have not yet been determined, but laparoscopic retropubic simple prostatectomy (LSP) is one of the preferred methods of surgical treatment for large-volume BPH. There are limitations to standard approaches to LSP, which necessitate the development of improved techniques.

Objective. To provide comparative analysis of the efficacy and safety of standard LSP and modified LSP combined with temporary clamping of the internal iliac arteries and vesicourethral anastomosis.

Materials & methods. The present multicenter study included 300 patients (mean age 67.0 ± 5.2 years) who were randomly assigned to standard and modified LSP groups. The main efficacy criteria of the intervention during 6 months of observation were: the severity of symptoms of urinary disorders (IPSS score), quality of life, peak urine flow rate and residual urine volume. All complications developed during the postoperative follow-up were recorded.

Results. Of the 300 patients, 149 underwent standard LSP, and 151 underwent a modified LSP. Significant differences were detected in the hospital stay (p = 0.032), the rate of decrease in hemoglobin (p = 0.020) and the irrigation time (p = 0.001). In addition, the use of the modified technique was associated with a lower incidence of short-term urinary incontinence (p = 0.031), urinary retention due to urethral catheter occlusion (p = 0.002), and incidence of bladder tamponade (p = 0.001). After 6 months of postoperative follow-up, the groups were comparable in most of outcomes, except for peak urine flow (23.9 ± 2.3 and 20.3 ± 1.9 ml/s in the modified and standard LSP groups, respectively, p = 0.001). After 6 months of postoperative follow-up, the modified LSP group had a lower incidence of bladder tamponade (p = 0.010), urge urinary incontinence (p = 0.002) and bladder neck contracture (p = 0.031).

Conclusion. The effectiveness of the modified LSP as a method of surgical treatment of large-volume BPH is not inferior to those in the standard LSP group, and the safety profile suggests the feasibility of wider testing of the technique in practice.
AI-Led Mental Health Support (Wysa) for Health Care Workers During COVID-19: Service Evaluation
Authors: Chang Christel Lynne , Sinha Chaitali , Roy Madhavi , Wong John Chee Meng
Published: March 2024

Background

The impact that the COVID-19 pandemic has had on health care workers’ mental health, in particular, cannot be ignored. Not only did the pandemic exacerbate mental health challenges through elevated stress, anxiety, risk of infection, and social isolation, but regulations to minimize infection additionally hindered the conduct of traditional in-person mental health care.

Objective

This study explores the feasibility of using Wysa, an artificial intelligence–led mental health app, among health care workers.

Methods

A national tertiary health care cluster in Singapore piloted the use of Wysa among its own health care workers to support the management of their mental well-being during the pandemic (July 2020-June 2022). The adoption of this digital mental health intervention circumvented the limitations of in-person contact and enabled large-scale access to evidence-based care. Rates and patterns of user engagement were evaluated.

Results

Overall, the opportunity to use Wysa was well-received. Out of the 527 staff who were onboarded in the app, 80.1% (422/527) completed a minimum of 2 sessions. On average, users completed 10.9 sessions over 3.80 weeks. The interventions most used were for sleep and anxiety, with a strong repeat-use rate. In this sample, 46.2% (73/158) of health care workers reported symptoms of anxiety (Generalized Anxiety Disorder Assessment-7 [GAD-7]), and 15.2% (24/158) were likely to have symptoms of depression (Patient Health Questionnaire-2 [PHQ-2]).

Conclusions

Based on the present findings, Wysa appears to strongly engage those with none to moderate symptoms of anxiety. This evaluation demonstrates the viability of implementing Wysa as a standard practice among this sample of health care workers, which may support the use of similar digital interventions across other communities.
Nomophobia, Psychopathology, and Smartphone-Inferred Behaviors in Youth With Depression: Longitudinal Study (Preprint)
Authors: Zhang Tianyi , Camargo Andres , Schmaal Lianne , Kostakos Vassilis , D'Alfonso Simon
Published: March 2024

BACKGROUND

Smartphones have become an indispensable part of people’s lives, and the fear of being without them, what has been termed “no mobile phone phobia” (nomophobia), is a growing phenomenon. The rise of problematic smartphone use highlights the urgent need to explore the intricate relationship between smartphones and human behavior. However, the connections between nomophobia, mental health indicators, smartphone use patterns, and daily activities remain largely underexplored.

OBJECTIVE

This study aimed to explore the relationship between young adults with depression and smartphones and investigate nomophobia by analyzing data obtained from a pilot study of depression in a youth cohort. Exploring nomophobia can enhance our understanding of the dynamics between young adults and smartphone use, potentially empowering them to manage and regulate their smartphone use more effectively.

METHODS

During an 8-week period, data collected via smartphone sensors, such as locations and screen status, were gathered from a cohort of 41 individuals diagnosed with major depressive disorder. In addition to passive-sensing smartphone data, the study collected ecological momentary assessments and psychometric measures, including the Nomophobia Questionnaire, which formed the basis of our investigation. We explored statistical associations among smartphone-derived behavioral features, psychometric indicators, and nomophobia. In addition, we used behavioral and psychometric data to develop regression models demonstrating the prediction of nomophobia levels.

RESULTS

Our findings revealed that the level of nomophobia was positively associated with depression and negative affect, lower geolocation movements, and higher comfort with smartphone sensing. The exploratory predictive linear regression models demonstrated the feasibility of predicting an individual’s Nomophobia Questionnaire score based on their smartphone sensing data. These models effectively used input features derived from both a combination of smartphone sensing data and psychometric measures and from smartphone sensing data alone.

CONCLUSIONS

Our work is the first to explore the relationship between nomophobia and smartphone sensor data. It provides valuable insights into the predictors of nomophobia level, contributing to the understanding of the relationship between smartphones and human behavior and paving the way for future studies.
Managerial challenges in Digital Health: a bibliometric and network analysis (Preprint)
Authors: Garçon Quentin , Cabanes Benjamin , Denis-Rémis Cédric
Published: March 2024

BACKGROUND

Digital health has emerged as a transformative force in modern healthcare systems, witnessing a surge in technological innovations and solutions over the past two to three decades. Some studies gave an overview of the keywords and journals to decipher the visibility of digital health. Despite the increasing focus on digital health, a critical gap persists in quantifying the trends of peer-reviewed publications specifically within the management and organization literature.

OBJECTIVE

To delineate the evolving landscape of digital health management literature from 1994 to 2022, this study aims to conduct a comprehensive bibliographic, bibliometric, and network analysis. By unveiling research trends and clusters, our objective is to contribute nuanced insights into the pivotal themes, influential works, and the structure of knowledge within this interdisciplinary domain. Additionally, we extend our investigation to identify and analyze literature clusters thanks to co-citation patterns, unraveling the intricate connections and themes that define the evolving landscape of digital health management research.

METHODS

After a keyword analysis, all peer-reviewed, published before 2023, English-written articles or reviews on Scopus were considered in our analysis as soon as the main focus was digital health or closely related keywords. To unveil clusters and trends, a bibliographic-bibliometric or co-citations network analysis was conducted using Gephi to identify clusters.

RESULTS

Out of 1186 papers about digital health or other highly-related keywords published between 1994 and 2022, 520 articles (43.8%) were included in the co-citation network and 468 papers were in significant clusters (>1% of the total number of nodes) and divided into 4 modularity classes. These 4 clusters were then interpreted using the highest centrality degree nodes of each cluster (“Adoption-engagement”, “Behavior-trust-privacy”, “Ecosystem transformations” and “Ethics-usage”) with an analysis of the keywords and the most cited articles.

CONCLUSIONS

Our co-citation analysis unveils evolving themes in digital health management literature. Our study provides a snapshot from 1994 to 2022. While we refrain from extensive citation analysis, our thematic exploration suggests dynamic shifts in ethical considerations, global healthcare organization, and societal and professional acceptance. Encouraging further research in these nuanced clusters, our study prompts ongoing exploration into the intricate facets of the digital health management literature. With a more comprehensive understanding of the digital health management literature dynamic, we also hope that this study provides management researchers and health researchers insights on the principal fields to address further unidentified gaps.
Cardiometabolic characteristics of type 2 diabetes patients depending on obesity phenotypes
Authors: Prybyla O.V. , Zinych O.V. , Kushnareva N.M. , Kovalchuk A.V. , Shyshkan-Shyshova K.O.
Published: March 2024

Background. The problem of studying the causes and mechanisms of metabolic disorders in metabolic syndrome and type 2 diabetes mellitus (T2DM) is one of the most important questions in modern medicine. It is due to the growing prevalence of dysmeta­bolic conditions and their serious consequences for the population health in the modern world. The initial hypothesis was that the differences in hormonal and metabolic conditions in patients with T2DM can be explained by the peculiarities of the anabolic-catabo­lic balance in different metabolic phenotypes. The aim of the work was to study the features of anthropometric and compositional parameters, indicators of carbohydrate, lipid and purine metabolism, anabolic-catabolic balance as predictors of cardiovascular diseases in patients with T2DM, depending on the phenotype. Materials and methods. One hundred and sixty-five patients with T2DM were included in the study, 71 women and 94 men aged from 32 to 82 years (59.0 ± 8.3 years). They had a level of glycated hemoglobin higher than 6.7 % (8.3 ± 1.8 %) against the background of taking oral hypoglycemic agents. Results. During the examination, it was found that the metabolism of patients without general obesity has a predominantly catabolic orientation, which, compared to those with general obesity, is manifested in a lower absolute accumulation of total and visceral fat, a reduced level of uricemia (due to a lower reabsorption of urate in the renal tubules, a lower activity of the anabolic pathway of reutilization), which is accompanied by a lower level of anabolic hormones, insulin and dehydroepiandrosterone sulfate (DHEA-S), and a higher level of the catabolic stress hormone cortisol. General obesity in patients with body mass index ≥ 30 kg/m2 is caused by the predominant influence of anabolic hormones (insulin, DHEA-S), which contribute to the de novo synthesis of fatty acids and purine bases, the reutilization of purines and the reabsorption of uric acid. This leads to the accumulation of fat in the subcutaneous and visceral adipose tissue and an increase in the level of uricemia under the conditions of a lower content of the catabolic hormone cortisol. Conclusions. The application of a set of anthropometric, composition biochemical and hormonal indicators allows for a differential diagnosis of alimentary hypokinetic (anabolic) and stress (catabolic) phenotypes in patients with T2DM. An additional characteristic of the metabolic status in T2DM may be the assessment of uric acid production and excretion in patients with varying degrees of obesity. The listed signs indicate an anabolic type of metabolism in obesity.
New opportunities for correction of hormonal disorders and oxidative stress in women with genital endometriosis
Authors: Semenyna H.B. , Hrytsko M.I. , Doroshenko-Kravchyk M.V. , Korytko O.O. , Fartushok T.V.
Published: March 2024

Background. Genital endometriosis is one of the most urgent problems of modern gynecology. Considering oxidative stress as a pathogenetic link of endometriosis, we believe it reasonable to use a combined drug containing superoxide dismutase, resveratrol, and zinc. The purpose of the work was to evaluate the effectiveness of the treatment for genital endometriosis supplemented with the use of superoxide dismutase, resveratrol, and zinc, taking into account the leading pathophysiological links of the pathology. Materials and methods. Thirty-seven women of reproductive age with genital endometriosis were under observation. Treatment in the first group was carried out in accordance with the Guideline Development Group recommendations. Thirty-nine women of the second group additionally received a drug containing superoxide dismutase, resveratrol, and zinc. The control group included 30 healthy women. The state of lipid peroxidation processes was assessed by the level of diene conjugates and malondialdehyde in the blood serum and the antioxidant defense system by the content of superoxide dismutase and glutathione peroxidase. To monitor the patients’ quality of life, pain syndrome was studied using the Visual Analogue Scale. Statistical processing of the obtained data was carried out by means of the standard StatSoft Statistica for Windows 13.0 program pac­kage. Results. The assessment of the pain syndrome in the second group showed that it completely disappeared in women with the first stage of the disease. Among patients with the second stage, pain disappeared in 8 cases, 3 patients had a decrease from severe to mild pain. At the third stage, pain disappeared completely in 5 women, in 4 cases, it decreased from severe to mild, and in one woman, the pain decreased from unbearable to mild. All patients of the second group noted a decrease in pain during intercourse, and in the first stage — its absence, an increase in work capacity (r = 0.64, p < 0.01), a decrease in irritability and anxiety in the perimenstrual period (r = –0.59, p < 0.05) and overall satisfaction with the treatment result. Side effects were not noted in any of the patients. Conclusions. Improving treatment for genital endometriosis by supplementing therapy with superoxide dismutase, resveratrol, and zinc is pathogenetically justified, as it has a significant positive effect on the lipid peroxidation and antioxidant defense system, compared to the traditional treatment regimen.
Relationship between hyperleptinemia and cardiometabolic risk in persons with obesity
Authors: Chernyavska I.V. , Kravchun N.O. , Dunaieva I.P. , Tykha I.A. , Oliynikova S.P. , Rassolova O.S.
Published: March 2024

Background. Obesity remains a global social and medical problem today. The results of recent research demonstrate the pre­sence of overweight in 30–70 % and obesity in 10–30 % of adults, while the prevalence of obesity is increasing at an alarming rate in both economically developed and developing countries of the world. In Ukraine, according to the World Health Organization, 41.2 % of men and 58.5 % of women are overweight or obese. Obesity is a risk factor for the development of a number of diseases — type 2 diabetes, hypertension, coronary heart disease, non-alcoholic fatty liver disease, gastroesophageal reflux disease, obstructive sleep apnea syndrome, etc. The presence of hyperleptinemia and weight loss resistance are common characteristics of obesity. The purpose of the study was to reveal the relationship between leptin levels and cardiometabolic risk in obese patients. Materials and methods. Fifty-three patients (43 women, 10 men) were examined. Body mass index was calculated as the ratio of body weight (kg) to height (m2). The classification criteria of the World Health Organization were used to diagnose overweight, obesity, and its degree. The level of leptin was assessed by an enzyme immunoassay on the ImmunnoChem-2000 device. The relationship between indicators was evaluated using the Spearman’s rank correlation coefficient. Results. Hyperleptinemia in obese patients is an indicator of low-grade inflammation. A significant increase in the serum leptin is noted in obese patients. Correlation analysis of waist circumference with leptin level in women and men demonstrated its importance both before and after treatment. A significant cardiometabolic risk was detected in the examined patients from the Ukrainian population. Against the background of a comprehensive treatment for six months, a decrease in body weight, waist circumference (p < 0.05) and in leptin level (p < 0.05) was noted in both women and men. Conclusions. The relationship was found between leptin level and cardiometabolic risk in obese patients.
Post-traumatic stress disorder, dyssomnias, and metabolic syndrome
Authors: Serhiyenko V.A. , Sehin V.B. , Pankiv V.I. , Serhiyenko A.A.
Published: March 2024

Post-traumatic stress disorder (PTSD) and metabolic syndrome (MetS) frequently coexist and share neurobiological and clinical features. In particular, the results of meta-analyses indicate a higher prevalence of MetS in patients with PTSD compared to the general population. PTSD is also a recognized risk factor for MetS. This synchronicity can be partially explained by pathogenetic pathways present in both conditions. These include genetic factors, dysfunction of the hypothalamic-pituitary-adrenal axis, chronic low-grade inflammation, oxidative stress, insulin resistance, and immune dysregulation. Thus, similar mechanisms are involved in the clinical worsening of PTSD and the development of adverse cardiovascular events associated with MetS. Dyssomnias are one of the characteristic clinical features of PTSD. Today, it is believed that posttraumatic circadian rhythm disorders are the core and not a secondary feature of PTSD, which mediate the neurobiological correlates of disorders due to homeostasis imbalance. At the same time, dyssomnias, chronodestruction, and depressive disorders are part of the pathogenesis of insulin resistance, obesity, and MetS. Thus, treatment of dyssomnias is one of the key tasks in the prevention and treatment of comorbid PTSD and MetS. Regulation of sleep processes and circadian rhythms through exogenous intervention, especially with melatonergic drugs, is likely to be a key part of preventing and treating dyssomnias in people who have both PTSD and MetS. The purpose of this review is to analyze the specifics of the relationships between PTSD and MetS, PTSD and dyssomnias, MetS and sleep disorders. We conducted the search in Scopus, Science Direct (from Elsevier), and PubMed, including Medline databases. The key words used were “post-traumatic stress disorder,” “dyssomnias,” “chronodestruction,” and “metabolic syndrome”. The identification of research findings that were not found during online searches involved manual searching of the bibliography of publications.
Stress-induced urgent conditions in endocrinology
Authors: Vyunytska L.V. , Yuzvenko T.Yu. , Dashuk T.I. , Nikonov V.V. , Vasyuk V.L. , Korotchuk N.V.
Published: March 2024

The literature review deals with the influence of chronic stress on the functioning of the endocrine system. The most significant pathological conditions induced by chronic stress are decompensation of carbohydrate metabolism, disorders of the thyroid gland, reproductive system, depressive disorders, electrolyte disorders. The significance of these pathologies is determined by a pronounced decrease in the quality of life, the occurrence of severe complications, and an increase in mortality. The development of hyperglycemia during the acute period of the disease is an established connection between the stress system and glucose homeostasis, which is confirmed by the development of stress hyperglycemia and increased morbidity. Glucocorticoids have a contrainsular effect, and the significance of their impact on carbohydrate metabolism is due to the pleiotropic action: induction of insulin resistance, stimulation of gluconeogenesis, increase in the blood content of glucagon due to dysregulation of its synthesis and secretion. The effects of stress on the thyroid gland are determined by its duration, characterized by the activation of the pituitary-thyroid system in the acute period and its suppression during long-term and chronic stress. The contribution of the stress component and glucocorticoid deficiency to the development of autoimmune thyroid diseases due to the suppression of cellular and strengthening of humoral immunity is discussed. Under conditions of psychological stress, the development of hypothyroidism was noted in emigrants with anxiety-depressive syndrome and insomnia, as evidenced by a decrease in the concentration of thyroid hormones. A decreased thyroid status in these patients is associated with the severity of chronic stress. Research data show that chronic stress can significantly change a person’s thyroid status, leading to the development of triiodothyronine deficiency syndrome and an increase in the production of inactive reverse triiodothyronine, inducing the development of hypothyroidism. It is possible that the pronounced growth of subclinical forms of hypothyroidism, noted in many countries of the world, is a consequence of chronic stress. The hypothalamic-pituitary-adrenal axis is involved in the formation of stress-induced reactions almost immediately after exposure to the stressor. Stress-induced changes in the endocrine system arise and develop in close connection, forming a vicious circle of pathological changes and emergencies.
Pulchrotes, nuevo subgénero de Paranomala (Coleoptera: Scarabaeidae: Rutelinae) y descripción de dos especies nuevas de México y América Central
Authors: Ramírez-Ponce Andrés , Delgado Leonardo , Mora-Aguilar Eder F. , Curoe Daniel J. , Zaragoza-Caballero Santiago
Published: March 2024

Pulchrotes subgen. nov. es descrito para ubicar a Paranomala doryphorina (Bates, 1888) y a 2 especies inéditas, P. chimalapensis sp. nov. y P. hondurana sp. nov., de México y Honduras, respectivamente. Este subgénero destaca por el inusual patrón de coloración dorsal y la complejidad de sus genitalia, que lo hacen difícil de vincular con el resto de las especies del género. Se discuten las posibles afinidades con otros subgéneros y especies, y se incluye una clave taxonómica para los subgéneros dentro de Paranomala y otra para las especies del subgénero Pulchrotes con láminas que incorporan caracteres diagnósticos y un mapa de distribución.
Role of Human Oral Microbiome in Diseases
Authors: Upadhyay Mansi , Swaroop Anushika , Sinhal Vijay Kumar , Srivastava Alok , Garg Sanjay Kumar , Singh Vijay Pal , Arora Pankaj Kumar
Published: March 2024

The human oral microbiome represents a diverse and intricate ecosystem comprising bacteria, fungi, viruses, and protozoa. It plays a vital role in numerous physiological processes, ranging from digestion to immunity. Recent research endeavors have focused on delineating the composition and functions of the oral microbiome. Changes in the oral microbiome have been associated with both oral diseases (such as dental caries, periodontitis, halitosis) and systemic conditions (including cardiovascular disease, diabetes, and cancer). Despite significant advancements, numerous questions about the role of the oral microbiome in health and disease remain unanswered. Further research is imperative to explore the intricate interactions between the oral microbiome and other microbiomes within the body. Additionally, there is a need to develop targeted interventions capable of selectively modulating the oral microbiome without disrupting other beneficial microorganisms. In summary, delving into the study of the human oral microbiome has the potential to revolutionize our comprehension of health and disease, opening avenues for innovative approaches to preventive and therapeutic medicine.
Prominent Classes of Antibiotics and their Mechanism of Resistance against Methicillin-Resistant Staphylococcus aureus
Authors: Sharma Shweta , Sharma Manik , Kumar Ajay , Vashisht Amit , Shahwan Moyad , Tuli Hardeep Singh
Published: March 2024

Methicillin-resistant Staphylococcus aureus (MRSA) is a prominent pathogenic, antibiotic-resistant microorganism that contains a variety of virulent characteristics having the capacity to develop tolerance to several major classes of antibiotics. The ongoing creation of clones enhances this potential, transforming S. aureus into an “Anti-Infective.” MRSA has started to rise as a Hospital-Acquired MRSA, but due to evolution, new strains of MRSA have been discovered throughout the past several years. The new strains of MRSA as Community-Acquired MRSA, and Livestock-Associated MRSA are infecting the patients despite preexisting medical conditions, being as susceptible to any treatment. The continuous expansion of MRSA is still ongoing. The main goal of this article is to improve reading comprehension of MRSA by studying the prominent classes of antibiotics and their mechanism of resistance which are now susceptible or getting susceptible to the MRSA.
Characterization and Distribution of SARS-CoV-2 Omicron Variant and its Sub-lineages in Uttarakhand using Next Generation Sequencing: A Retrospective Study
Authors: Pal Shekhar , Rana Geetika , Singhal Shweta , Singh Minakshi , Kumar Manish , Thaledi Shweta
Published: March 2024

The etiological agent of coronavirus disease (COVID-19) that emerged at the end of year 2019 was first reported in Wuhan, China and was found to be SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). The massive COVID-19 waves were due to various variants. As per the reports of other study it was also found that Omicron variant spread faster than various other variant such as delta variant. Omicron has been reported from various countries and now from many states of India too. Therefore, keeping this in mind, this study was undertaken to study all the lineages of SARS-CoV-2 Omicron variant of disease COVID-19 that are circulating in the population of Uttarakhand with objective to study next generation sequencing of all the RT-PCR positive of SARS-CoV-2 and to find out all the lineages of the Omicron variant of SARS-CoV-2. This was a retrospective study conducted from 1st January 2022 to 30th September 2022. Next generation sequencing was performed on all the samples that were tested for COVID-19 by using Ion AmpliSeq kit on Ion Chef instrument. A total of 2149 samples were tested in which majority of samples belong to age group of 21-40 years. Males were affected more than females. BA.2 was found to be the predominant lineage of total of 46 lineages that were identified. Their mutations were also studied. We conclude that different variants of clade 21L, 22B, 22D and Omicron subvariant BA.2, BA.2.38 and BA.2.75 were the ones that were circulating amongst the population of Uttarakhand. The characteristic mutation that was found were T19I and V213G in NTD, S373P, S375F, T376A, and D405N in RBD.
Antimicrobial Activity against Antibiotic-resistant Pathogens and Antioxidant Activity and LCMS/MS Phytochemical Content Analysis of Selected Medicinal Plants
Authors: Thakur Mony , Khushboo  , Yadav Ankita , Dubey Kashyap Kumar , Dakal Tikam Chand , Yadav Vinod
Published: March 2024

Medicinal plants are a major source of numerous therapeutic agents, and the emergence of pathogenic bacteria has rekindled interest in traditional medicine systems as an alternative approach to overcoming resistance. The dried plant material of four medicinal plants, namely Terminalia arjuna (bark), Terminalia bellirica (fruit), Aegle marmelos (leaves), and Bacopa monnieri (leaves), was powdered, and aqueous extracts were prepared. The antimicrobial activity of the extracts was evaluated against three clinically important strains: Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli 385. As E. coli 385 was resistant to the broadest spectrum of antibiotics tested, it was classified as (MDR multi-drug resistant). E. coli, Bacillus subtilis, Mycobacterium smegmatis (MTTC), and Vibrio alginolyticus (ATCC) were also assessed using the agar well diffusion method for zones of inhibition and minimum inhibitory/bactericidal concentration (MIC/MBC). Clinically important strains were found to be sensitive to the aqueous extract of T. bellerica (19.51 ± 0.61 mm) with MICs ranging from 0.31 to 0.62 mg/ml. The MDR strain was also sensitive to Bellirica monnieri (16.10 ± 0.31 mm) aqueous extract. To determine the potential for a wide range of applications, the antioxidant activities of the extracts were evaluated using DPPH, ABTS, and FRAP assays. The T. arjuna plant extract exhibited the highest radical scavenging activity with the lowest EC50 values for DPPH (1.15 ± 0.061 mg/ml) and ABTS (1.02 ± 0.07 mg/ml). The plant extracts were characterized by UV-visible spectroscopy, Fourier-transform infrared spectroscopy, and LC-MS/MS.
Naglasak posuđenica u osječkome govoru
Authors:   Centre for Providing Services in Community Klasje Osijek, Croatia, Rajle Lorna
Published: March 2024

Brojni radovi pokazuju da se hrvatski govornici ne pridržavaju pravila koje kazuje da se u hrvatskome jeziku silazni naglasak ne može ostvarivati na nepočetnome slogu riječi. Silazni se naglasak uglavnom javlja u sklopovima prednaglasnica i naglasnica, posuđenicama, vokativu jednine i genitivu imenica, vlastitim imenima, složenicama, stilističkim riječima i u oblicima glagola. Takav izgovor uobičajen je i kod nekih izvornih novoštokavaca s četveronaglasnim sustavom, koji je dijelom osnovica hrvatske ortoepske norme. U osječkome govoru, kao primjeru novoštokavskoga dijalekta, također se primjećuje uporaba silaznoga naglaska na nepočetnome slogu određenih kategorija riječi. Kao prilog opisu uzusa, na temelju kojega bi se mogle uskladiti teorija i jezična praksa, u radu se opisuju naglasne navike Osječana u izgovoru posuđenica (posebice izvedenica sa sufiksima na -st, -nt, -or i -log te posuđenica koje nisu izvedenice, ali koje se analogijom prisličuju izvedenicama na navedene sufikse) i ženskih mocijskih parnjaka tvorenih od muških parnjaka posuđenica na -nt, -or i -st te se utvrđuju uvjeti u kojima se ostvaruje silazni naglasak. Također se opisuju razlike u naglašivanju posuđenica s obzirom na dob osječkih govornika.
Visualizing Algorithms in the Field of Education: A Comprehensive Review
Authors: Singh Varun , Dubey Sudhanshu , Ahmad Er. Asim
Published: March 2024

Abstract: Visualization of algorithms can enhance computer science education by offering a beneficial method for comprehending intricate concepts within engineering courses. An electronic learning tool has been created to cover various algorithms, including sorting algorithms, prime numbers, recursive sorting algorithms, and the N Queen problem. Employing animation as a means of conveying information, the tool enables users to select data ordering and algorithms. Users can either initiate automatic animation or progress through the steps at their own pace. Additionally, the pathfinding algorithm permits usersto modify the starting and ending nodes. This e-learning tool serves as both a standalone application and a complementary resource for in-person training, providing a visual representation of the execution stages of algorithmic rules.
Image Transform and Hybrid Optimization Based Feature Reduction for Leaf Diseases Classification
Authors: Shivani Dr. J. L. Divya , A Dr. Veera Babu
Published: March 2024

Abstract: In recent years, there has been amazing progress in technology innovation across many sectors, including medical care, homeland security, the arts, and even agriculture. The ability to run one's business well is highly regarded in every sector. Because to recent advancements in technology, such as smart phones and the Internet of Things, this is now a distinct possibility. In this research, we offer a smart management system for horticulture that makes use of machine learning methods. This system is based on the smart management scheme that was previously described. As a component of horticulture management, many academics have advocated for the use of machine learning to analyse plant growth based on the features of the leaf. We used the grayscale image, which employed numerous features for classification while simultaneously normalising the pixel values. As a consequence of this, the processing of damaged leaves in their early stages takes more time and results in less accurate classification. As a result, for the purpose of this work, we do a colour space conversion in order to investigate the image in terms of hue, saturation, and value. Following that, it extracted features from the Value channel by making advantage of the histogram's attributes. After that, the best characteristics were chosen by a process that included both particle swarm and cuckoo search optimisation. Following this, a regression neural network was trained to classify data based on the features that had been selected in the previous step. In order to evaluate how effective the proposed strategy is, classification performance criteria such as accuracy, sensitivity, and specificity were utilised. The suggested approach was tested in a simulated Windows 10 environment using a real-time dataset and the MATLAB software. It was compared to other methods that are already in use. While evaluating performance, comparisons to the current state of the art are conducted with regard to accuracy, sensitivity, and specificity
Investigating the influence of ambiguity tolerance and resilience on student engagement: A literature review
Authors: Kianinezhad Neda
Published: March 2024

The field of education has experienced a profound impact with the emergence of positive psychology (PP), leading to a heightened emphasis on engagement as a crucial construct. Simultaneously, individual differences, particularly ambiguity tolerance, have gained recognition for their pivotal role in the learning process and their influence on learners' engagement. In contrast, resilience has emerged as a potent tool for engaging English as a foreign language (EFL) learners, empowering them to adeptly navigate and overcome challenging circumstances and setbacks. However, despite the acknowledged significance of ambiguity tolerance and resilience in educational contexts, their roles within the domain of foreign language learning remain underexplored. This review sets out to investigate the influence of ambiguity tolerance and resilience on EFL learners' engagement. The study presents compelling evidence, underscoring the substantial roles that ambiguity tolerance and resilience play in fostering learners' engagement. The major finding of this research is the identification of ambiguity tolerance and resilience as crucial factors in enhancing EFL learners' engagement. Following that, building upon these findings, the paper offers practical implications and suggestions for effectively integrating these constructs into foreign language education. Finally, the ultimate goal is to enhance students' overall engagement and enrich their learning experiences.
Tri Hita Karana for environmental resilience: Enhancing coral reef conservation and sustainable practices in Mengiat Beach Bali
Authors: Suryawan Tjokorda Gde Agung Wijaya Kesuma , Putri Cokorda Istri Agung Vera Nindia , Geriadi Made Ayu Desy , Dwijayanthi Anak Agung Istri , Miranti Riyana
Published: March 2024

This collaborative international community service initiative applies the Tri Hita Karana philosophy to improve coral reef conservation at Bali''s Mengiat Beach. The collaboration between Universitas Ngurah Rai and the University of Canberra integrates traditional wisdom and innovative methods, promoting resilience, sustainable practices, and economic growth while adhering to Tri Hita Karana''s holistic principles. The initiative program combines Marine Protected Areas (MPAs) and the Mars Assisted Restoration System (MARRS) to safeguard coral ecosystems. Participatory Action Research (PAR) empowers communities, aligning with the holistic principles of Tri Hita Karana. The methodology encompasses preparation, education, hands-on training, beach clean-ups, and continuous evaluation, reinforcing coral preservation while promoting sustainable practices and ecological well-being. These strategies align with the Tri Hita Karana philosophy, promoting local engagement and resource management. The donation of Reef Stars by the universities to the Bali Coastal and Marine Biodiversity Foundation reflects a commitment to environmental well-being and long-term harmony. The Mengiat Beach collaboration by two universities and the Bali Coastal and Marine Biodiversity Foundation integrates traditional wisdom and modern methods within the Tri Hita Karana philosophy. Through education, training, and reef restoration, the initiative emphasizes community engagement and ecological resilience.
Implementation of scouting techniques material on first aid for accidents in scouts of Gudep Bumi Bahari
Authors: Ummah BK Muh. Khaerul , Hamna H. , Rahmawati Karmila Risa , Hidayat Syaiful , Amelia Ananda
Published: March 2024

Scouting is one of the activities of forming discipline, morals, character, and mental development with a learning process outside the school environment and outside the family environment which is packaged in an interesting and fun way carried out in the open air. There are two kinds of scout learning material, namely knowledge learning and scouting techniques. In scouting activities there are several scouting techniques that are often used for example camping, exploration, terrain orientation, and mountain climbing. Therefore, it is necessary to implement the scouting technique of scout first aid material for scouts through a Community Service program that is integrated with lecture activities at the project location to implement the scouting technique of scout first aid material for scouts in Gudep Bumi Bahari so that scouts in Gudep Bumi Bahari can know and apply every step in performing first aid in accidents during scouting activities.  The purpose of this service is to increase the knowledge and skills of the first aid of the Cub Scouts, because the knowledge of first aid in the accident of the Cub Scouts of Gudep Bumi Bahari is still lacking.   The method used in this community service is lecture-based coaching, practice and educational games, interviews are conducted as a final evaluation. The service program carried out with the project implementation team can be carried out according to targets such as increasing the understanding and skills of Scouts related to first aid material at Gudep Bumi Bumi Bahari in SD Negeri Pulias Abaling.
SOSTAC framework analysis for enhancing digital marketing in Yogyakarta's Art Music Today
Authors: Anggraeni Novi , Sulistyowati Tussi , Husda Nur Elfi
Published: March 2024

This research utilizes a qualitative descriptive methodology, employing the SOSTAC model to analyze Art Music Today (AMT). The study follows six structured steps, starting with a SWOT-based Situation Analysis highlighting AMT's strengths as a unique Yogyakarta entity. Strategic objectives are set using the 5s Framework, focusing on digital marketing elements like online sales optimization and user experience. The Strategy phase emphasizes STP marketing, presenting AMT as a tailored music information center. Tactics, guided by the 7P framework, include product diversification and pricing strategies, contributing to an enhanced user experience. An 18-month action plan, depicted in a Gantt chart, guides implementation from content creation to streamlined processes. The Control phase involves monitoring with Google Analytics and social media evaluation. Through leveraging strengths and addressing weaknesses, AMT positions itself for growth in the digital landscape, using the SOSTAC model as a robust framework for digital marketing excellence.  As a suggestion, through a proactive approach to leveraging inherent strengths and addressing weaknesses, AMT aims for significant growth in the dynamic digital environment. Aligning its digital marketing efforts with the SOSTAC model, which covers Situational Analysis, Objectives, Strategy, Tactics, Action, and Control, ensures a comprehensive understanding of current market dynamics. This strategic alignment establishes the foundation for a well-defined and actionable digital marketing strategy.
Utilization of waste paper as teaching media for volcano eruption simulation in improving student knowledge
Authors: Hamna H. , Hidayat Syaiful , Ummah BK Muh. Khaerul , Rahmawati Karmila Risa , Rivani R. , Nurmasayu Andi , Yago Ribka , Wahyuni Ni'mah
Published: March 2024

Indonesia has the highest number of active volcanoes in the world due to its geologic location at the confluence of the Eurasian and Australian plates. However, despite this, the knowledge of local communities regarding volcanic eruptions is still very minimal. Therefore, it is important to provide education to the community in this context is the local community. This Community Service Program aims to increase community knowledge related to the process of volcanic eruption by using pulp-based learning media, so that it can become disaster mitigation knowledge. The methods used are observation, coaching or training based on practical simulations, questionnaires and interviews. The subject of this Community Service is the community of Tambun village, Baolan sub-district, Tolitoli district, totaling 21 people in collaboration with students of the elementary school teacher education program in semester III. The results of this program are the increase in community knowledge related to volcanic eruptions and the growth of community awareness related to the use of waste paper, this is in line with SDGs 4 and SDGs 17 relating to quality education and partnerships with the community.
The Mediating Effect of Self-Management Competency on the Relationship between Social Anxiety and Clinical Competency in the First Clinical Practice of Nursing Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee SuJeong
Published: March 2024

Objectives This study was conducted to investigate the mediating effect of self-management competency in the relationship between social anxiety and clinical competency in nursing students' first clinical practice. This study analyzed the differences in social anxiety, self-management competency and clinical competency before and during clinical practice in nursing students' first clinical practice and verified the mediating effect of self-management competency in the relationship between social anxiety and clinical competency.
Methods The subjects of the study were 95 third-year nursing students experiencing their first clinical practice at a university in Chungbuk. The research data measured social anxiety, self-management competency and clinical competency twice before and during the first clinical practice. The difference analysis before and during the first clinical practice was performed by paired t-test, the relationship between variables was analyzed by Pearson correlation analysis, and the mediating analysis was analyzed by hierarchical regression analysis and the significance of the path was analyzed by boostwrapping using SPSS macro process Model 4.
Results In the first clinical practice of nursing students, there was no significant difference between social anxiety and self-management competency, but clinical competency was significantly improved in the measurement results before and during clinical practice. The relationship between variables showed a negative correlation between social anxiety and self-management competency, and a negative correlation between social anxiety and clinical competency but a positive correlation between self-management competency and clinical competency. This study found full mediating effect of self-management competency on the relationship between social anxiety and clinical competency.
Conclusions The Self-management competency has been identified as a necessary competency to overcome social anxiety and achieve the goal of clinical competency in nursing students' university life and clinical practice, and it is necessary to develop a program to improve self-management competency in the future.
Research Trends on Hikikomori in Korea
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Do-Hee
Published: March 2024

Objectives The purpose of this study is to examine the trajectory of hikikomori research in Korea, aiming to provide a comprehensive overview.
Methods Utilizing a content analysis, we scrutinized 46 peer-reviewed academic journal papers to discern publication trends, evolving keywords, research design and participant demographics.
Results The results reveals a noteworthy evolution in the landscape of hikikomori research. Commencing in 2003, an initial publication emerged, followed by a brief hiatus in 2004-2006. Since 2007, a consistent output of 1-3 studies annually has been observed, with a marked surge in publications observed from 2020 onwards. Notably, diverse disciplines contributed to the discourse, with a sequential prevalence in psychological science, humanities, sociology, and social welfare. In the early stages (2003-2020), scholars focused on themes such as ‘youth,’ ‘Internet addiction,’ and ‘maladjustment.’ In contrast, the subsequent period (2020-2023) witnessed a shift towards investigating the ‘8050 problem,’ ‘youth,’ and ‘social isolation.’ Since 2020, the term ‘eundunhyeong oetoli (reclusive loner)’ has been more actively used than ‘hikikomori.’ Disciplinary disparities emerged in research methodologies. Humanities and sociology predominantly engaged in the analysis of secondary data, literary works, and movies, while social welfare and psychological science prioritized empirical data analysis. Commonly employed measurement tools included the Beck Depression Inventory (BDI) and Social Avoidance and Distress (SAD). The subjects of the study included not only hikikomori themselves, but also their parents, mental health practitioners, social workers, people with physical or mental disabilities, and the elderly living alone. The most common criteria for being a hikikomori were as follows: (1) non-attendance at school or work, (2) aversion to social interactions, and (3) home confinement exceeding (4) three months.
Conclusions The significance of this study is that it systematically organized and presented the research flow on hikikomori that has grown over the past 20 years. The limitations and implications for follow-up research were discussed.