bluuebunny/crossref_metadata_2025 huggingface dataset:
Neural networks for topology optimization
Authors: Sosnovik Ivan , Oseledets Ivan
Published: July 2019

In this research, we propose a deep learning based approach for speeding up the topology optimization methods. The problem we seek to solve is the layout problem. The main novelty of this work is to state the problem as an image segmentation task. We leverage the power of deep learning methods as the efficient pixel-wise image labeling technique to perform the topology optimization. We introduce convolutional encoder-decoder architecture and the overall approach of solving the above-described problem with high performance. The conducted experiments demonstrate the significant acceleration of the optimization process. The proposed approach has excellent generalization properties. We demonstrate the ability of the application of the proposed model to other problems. The successful results, as well as the drawbacks of the current method, are discussed.
Playing peripatos: Creativity and abductive inference in religion, art and war
Authors: Mandoki Katya
Published: July 2019

Peirce proposed the concept of abductive inference to inquire into the generation of new hypotheses and defined it as another term for pragmatism, no less (Admitting, then, that the question of Pragmatism is the question of Abduction, let us consider it under that form. What is good abduction? What should an explanatory hypothesis be to be worthy to rank as a hypothesis? Of course, it must explain the facts. But what other conditions ought it to fulfill to be good? The question of the goodness of anything is whether that thing fulfills its end. What, then, is the end of an explanatory hypothesis? Its end is, through subjection to the test of experiment, to lead to the avoidance of all surprise and to the establishment of a habit of positive expectation that shall not be disappointed (Peirce. 1931–1966. The collected papers of Charles S. Peirce, 8 vols., C. Hartshorne, P. Weiss & A. W. Burks (eds.). Cambridge: Harvard University Press. 5.197)). Apart from being linked to the vague idea of the play of musement as an almost dreamlike process of epiphany or inspiration or as an inverted minor premise from a syllogism, we are far from understanding the dynamics and specificity of this kind of inference. Among authors dealing with this problem I could trace three factors at work in processes of abduction, i.e. combination, resemblance, and dialetics or questioning. In this paper I attempt to look a bit further into this enigma by a category of play I defined as “peripatos” or games of invention, riddles, and puzzles, hoping it could shed some light on the process of creativity in several social activities such as science, art, war, and religion. The approach will take on Huizinga’s idea of the play of culture, Lakoff and Johnson’s conception of cross-domain correlations, Kant’s view of “aesthetic ideas,” and my proposal of the play of peripatos through a “what if-as if” coupling into this very common yet little understood, and thus mystified, process of the generation of innovative ideas.
The role of uncertainty on agricultural futures markets momentum trading and volatility
Authors: Czudaj Robert L.
Published: July 2019

This paper sheds light on the role of different sources of uncertainty on agricultural futures markets momentum trading and volatility. Momentum trading is proxied by two technical analysis indicators – the moving average convergence divergence and the relative strength index – while we also consider two different concepts of uncertainty – the CBOE volatility index of the S&P500 and daily news about the stance of economic policy in the US. To capture different effects on the transmission mechanism of uncertainty shocks, we implement a Bayesian VAR approach, which accounts for time-variation in the coefficients and the variance covariance structure of the model’s innovations. The results point in favor of a time-dependent uncertainty effect on expectations of daily momentum traders in agricultural futures markets. The corresponding trades in these periods push futures prices upwards and downwards and result in an increased volatility. Direct effects of both uncertainty sources on the volatility of agricultural futures markets confirm this view.
Interleukin-6 signaling pathway involved in major depressive disorder: selective serotonin reuptake inhibitor regulates IL-6 pathway
Authors: Askari Marziye , Jahangard Leila , Zamani Alireza , Haghighi Mohammad , Salehi Iraj , Zareighane Zohre , Solgi Ghasem , Shahbazi Reza , Alahgholi-Hajibehzad Mahdi
Published: July 2019

Background

Evidence indicates that pro-inflammatory Th17 and Th1 cells are involved in major depressive disorder (MDD) pathogenesis. Development of Th17 and Th1 are regulated by IL-6 and IFN-γ, respectively. In this study, the levels of IL-6 and IFN-γ, and mRNA expression of related signaling components and, Th17/Th1 transcription factors were investigated in MDD patients with/without selective serotonin reuptake inhibitor (SSRI) medication.

Materials and methods

Forty-six patients and 38 healthy controls (HCs) were recruited. Twenty patients were received the SSRI (sertraline 50–200 mg/day) for at least 1 year, and 26 patients were not received medication. Expression of IL-6R, IFN-γR, JAK1, JAK2, TYK2, STAT1, STAT3, T-bet and RORγt were assessed with Real-Time-PCR. Serum and supernatant levels of IL-6 and IFN-γ were determined using ELISA.

Results and discussion

The serum and supernatant levels of IL-6 were increased in patients without (SSRI−) compared with HCs, while its levels was reduced in SSRI+. Elevated expressions of IL-6R, STAT3 and RORγt were observed in SSRI− compared with HCs. Expressions of IL-6R, STAT3, RORγt and IFN-γR, were decreased in SSRI+ compared to SSRI− patients.

Conclusion

Increased IL-6 involved in MDD, and SSRI regulates IL-6 pathway and IL-6 production. MDD patients may benefit from IL-6/IL-6R targeted therapeutic intervention.
Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk
Authors: Rizzolo Piera , Silvestri Valentina , Valentini Virginia , Zelli Veronica , Bucalo Agostino , Zanna Ines , Bianchi Simonetta , Tibiletti Maria Grazia , Russo Antonio , Varesco Liliana , Tedaldi Gianluca , Bonanni Bernardo , Azzollini Jacopo , Manoukian Siranoush , Coppa Anna , Giannini Giuseppe , Cortesi Laura , Viel Alessandra , Montagna Marco , Peterlongo Paolo , Radice Paolo , Palli Domenico , Ottini Laura
Published: July 2019

Breast cancer in men is a rare and still poorly characterized disease. Inherited mutations in BRCA1, BRCA2 and PALB2 genes, as well as common polymorphisms, play a role in male breast cancer genetic predisposition. Male breast cancer is considered a hormone-dependent tumor specifically related to hyperestrogenism. Polymorphisms in genes involved in estrogen biosynthesis and metabolism pathways, such as CYP17A1 and CYP1B1, have been associated with breast cancer risk. Here, we aimed to investigate the role of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk. A series of 597 male breast cancer cases and 1022 male controls, recruited within the Italian Multicenter Study on male breast cancer, was genotyped for CYP17A1 rs743572, CYP1B1 rs1056836 and rs1800440 polymorphisms by allelic discrimination real-time PCR with TaqMan probes. Associations with male breast cancer risk were estimated using logistic regression. No statistically significant associations between male breast cancer risk and the three analyzed polymorphisms emerged. Similar results were obtained also when BRCA1/2 mutational status was considered. No significant differences in the distribution of the genotypes according to estrogen receptor status emerged. In conclusion, our study, based on a large series of male breast cancer cases, is likely to exclude a relevant role of CYP17A1 and CYP1B1 polymorphisms in male breast cancer predisposition. Overall, these results add new data to the increasing evidence that polymorphisms in these genes may not be associated with breast cancer risk.
Existenciales y cuantificadores en mocoví (Guaycurú, Argentina)
Authors: Carrió Cintia
Published: July 2019

En mocoví se reconoce un elemento al que le atribuimos el estatuto categorial de verbo (defectivo), si bien previamente ha sido tratado en la bibliografía como «partícula existencial». Es una forma productiva que interviene en diferentes procesos morfológicos y sintácticos habilitando distintas lecturas: presentativa-locativa, identificativa, posesiva, causativa, de cambio de estado y atributiva mediante predicación secundaria. La forma no marcada reviste en la clase de los verbos inacusativos y supone una vinculación a una entidad o a un lugar del cual se predica la falta o la presencia de algo. Se reconocieron tres formas afirmativas no alomórficas y una forma negativa. Aquí se pone en relación la materialización del existencial con contextos cuantificados por diferentes elementos. Este estudio tiene por objetivo avanzar en el conocimiento del comportamiento de las construcciones existenciales y de las cuantificacionales (poco exploradas); apunta a organizar el sistema léxico y gramatical de la cuantificación, comenzando por explorar los contextos ligados a las construcciones existenciales.
Postpositions in Munduruku (Tupi): Formal and Functional Features
Authors: Gomes Dioney M.
Published: July 2019

The Munduruku people live in the states of Pará and Amazonas, including a handful of residents in Mato Grosso, in Brazil. My research about the language takes place within the Munduruku population of Pará. It is a language of the Tupi stock, that belongs to the Munduruku family. It is of head-marking type. The most common constituent order is s(o)v. The arguments do not receive morphologic marks, usually occurring in noun phrases. The verb receives person marks, which indicate/co-refer subject and direct object. Our objective here is to present the inventory of the postpositions,  in order to discuss the properties they share; what their structural and functional features are; and their participation in the passive voice, causative, subordination, modality, source of information, and locative and possessive predication. We also approach the isomorphism among postpositions, nouns and verbs; the syntactic relation that establishes the postpositional phrase with the rest of the sentence: whether argument or adjunct. Finally we will also reflect upon its typology.
Tiempo nominal en tikuna (Yurí-Tikuna)
Authors: Montes R. María Emilia
Published: July 2019

En tikuna el paradigma tripartito de femenino, masculino y pasado es un paradigma de clase nominal altamente gramaticalizado, concordante y de ineludible expresión en una serie de contextos gramaticales. La fusión del paradigma de género y de tiempo es un fenómeno relativamente original del tikuna. Los nominales expresan solo las categorías de ‘pasado’ y de ‘no pasado’, a diferencia de lo que ocurre en lenguas en las cuales hay también marcadores para tiempo nominal futuro o para pasado remoto. Tipológicamente el tikuna pertenecería al grupo en el que el tiempo nominal tiene alcance proposicional. Estas categorías nominales, además, se extienden a algunos conectores discursivos, otro comportamiento parcialmente original de esta lengua. En el género narrativo se atestigua ampliamente la presencia de estas formas con valor temporal y modalizador.
RETORIKA KHATIB DALAM PENYAMPAIAN KHUTBAH JUM’AT
Authors: Yuhesdi Luthfi , Bukhari Bukhari , Zainal Zainal , Sarwan Sarwan
Published: July 2019

The background of this research is because of the reality in the field, that the Friday sermon delivered by the khatib has yet to have a good appeal in the sermon. The purpose of this study First is to know how the style of the khatib in the delivery of the Friday sermon, Secondly, to know how the choice of the word of the khatib in the delivery of the Friday sermon, Third, to know how the tone of the khatib in the delivery of Friday sermon, and Fourth, to learn how the sentence structure of the khatib in the delivery of the sermon of Friday. This study uses a qualitative research methodology with observation data collection techniques, and interviews. This study found that the application of rhetoric by the Friday khutib in the sermon had not fully progressed as most khatib had not yet understood rhetoric. This is evident from the diction applied by the khatib not in accordance with the condition of the congregation, the application of repetition of the word does not conform to the rules of repetition. And there's also a lot of words. The relationship between sentence one with another sentence still does not use the correct word. And the emphasis on what matters is still not seen. The intonation conveyed by the khatib has not produced the appropriate variation, then the presentation is still monotonous and creates the jema'ah friday.
Első lépés egy egységes szemlélet felé: az Alkohol Megvonási Skála bevezetése a hazai betegellátási gyakorlatba
Authors: Lázár Bence András , Pribék Ildikó Katalin , Kovács Csenge , Demeter Ildikó , Kálmán János , Szemelyácz János , Kelemen Gábor , Janka Zoltán , Demetrovics Zsolt , Andó Bálint
Published: July 2019

Abstract:

Introduction and aim: The available literature and protocols have unequivocally suggested that the Clinical Institute Withdrawal Assessment of Alcohol, Revised is a psychometric scale for identifying and following the signs of alcohol withdrawal. However, there has not been any validated tool for the identification of withdrawal symptoms in Hungarian general hospital settings. The aim of the present study was to evaluate the validity and the reliability of the Hungarian version of this scale among patients hospitalized with alcohol withdrawal syndrome. Method: The translation of the scale into Hungarian was done by ‘back translation’ method, followed by testing the face validity. The empirical phase was performed in the Department of Psychiatry, University of Szeged. Patients admitted with alcohol withdrawal syndrome (n = 30) were recruited from the inpatient units of the clinic. Clinical Institute Withdrawal Assessment of Alcohol, Revised and Clinical Global Impression – Severity Scale were recorded every two days. Statistical comparisons of data were performed with repeated-measures ANOVA. Cronbach’s alpha, item-total correlation, convergent and discriminant validity were determined. Results: Significant decrease of the total scores of Clinical Institute Withdrawal Assessment of Alcohol, Revised and Clinical Global Impression – Severity Scale was observed between the six measurements (F = 202.46, p<0.001; F = 503.04, p<0.001). Cronbach alpha values were above 0.7 during the first 3 measurement days. The withdrawal and severity scores recorded the same day showed positively significant correlations (>0.45). Conclusion: Our findings demonstrate that the Clinical Institute Withdrawal Assessment of Alcohol, Revised is a reliable and valid psychometric tool for the detailed analysis of withdrawal symptoms in Hungarian general hospital settings. Orv Hetil. 2019; 160(30): 1184–1192.
PARTISIPASI POLITIK KAUM PEREMPUAN BERDASARKAN PANDANGAN FATIMA MERNISSI DAN YUSUF QARDHAWI
Authors: Jourdy Gayatri Belina
Published: July 2019

Abstrak: Discussions about the women involvement of in political are always becomes hot topic to discuss as long as women are still underestimated by some people. One of the most dominant works related to women as head of state is what Fatima Mernissi did in her book “The Forgotten Queens of Islam”, explains how women may becomes heads of state. In contrary, Yusuf Qardhawi argued that women may serve as head of state if only as judicial or legislative leaders, not as an executive leader. Through  descriptive-analytic-comparative method, this research tried to describe and explain Fatima Mernissi and Yusuf Al-Qardhawi's views on Women's Political Participation as Head of State, and how their argument can be applied in current life.Abstrak: Perbincangan mengenai keterlibatan perempuan dalam politik akan selalu menjadi perbincangan yang hangat selama masih ada sebagian orang yang memandang sebelah partisipasi perempuan sebagai kepala negara. Salah satu karya fenomenal yang mem­bahas tentang partisipasi perempuan sebagai kepala negara adalah  buku “Ratu-ratu Islam yang Terlupakan” karya Fatima Mernissi yang menyatakan bahwa perempuan boleh menjabat sebagai kepala negara secara mutlak. Hal yang berbeda diungkapkan oleh Yusuf Qardhawi yang menyatakan bahwa perempuan tidak memiliki partisipasi mutlak sebagai kepala negara, perempuan diperbolehkan menjabat sebagai kepala negara dengan syarat-syarat tertentu. Melalui metode deskriptif-analitik-komparatif, penulis mendeskripsikan, menjelaskan, serta membandingkan pandangan kedua tokoh tersebut  dan menganalisa bagaimana relevansi pendapat keduanya dalam kehidupan di masa kini.
PERSPEKTIF SIYÂSAH DUSTÛRIYAH ATAS HAK POLITIK PEREMPUAN DALAM MUSREMBANG KOTA BOGOR
Authors: Yulianis Erma
Published: July 2019

AbstrakPelaksanaan Perda Kota Bogor No. 2 Tahun 2008 tentang Tata Cara Penyusunan Rencana Pembangunan Daerah menjadi suatu pijakan dalam penyelenggaraan perencanaan pembangunan daerah yang harus bersifat partisipatif dan melibatkan seluruh elemen masyarakat. Hal ini jauh dari apa yang seharusnya terjadi berdasarkan Perda tersebut khususnya Pasal 29 Ayat (4) Huruf B Angka (6) yang menyebutkan bahwa keterwakilan perempuan seharusnya dapat diperhatikan. Penelitian ini berangkat dari konvensi mengenai penghapusan segala bentuk diskriminasi terhadap wanita dan merupakan prinsip dalam Siyasah Dusturiyah yakni, prinsip persamaan (musawwah). Bahkan dalam Islam, perempuan juga mempunyai kewajiban untuk mengamalkan amar ma’ruf nahi munkar. Penelitian ini dilakukan dengan metode deskriptif yaitu, memaparkan atau menggambarkan hasil penelitian dengan apa adanya. Sumber data yang digunakan yaitu berupa sumber data primer yakni, sumber data pokok yang diambil dari 6 kantor kecamatan Kota Bogor sedangkan sumber data sekunder yakni, data pelengkap berupa teori dan tinjauan kepustakaan. Pertama, implementasi hak politik perempuan melalui kegiatan Musrenbang di enam kecamatan berdasarkan Perda tersebut, tiga diantaranya memenuhi affirmative action 30%. Kedua, hak politik perempuan dalam Musrenbang berdasarkan Perda tersebut ialah berupa hak menyampaikan pendapat, memaparkan program pembangunannya. Ketiga, Siyasah Dusturiyah juga mempertegas hak mengemukakan pendapat bagi kaum perempuan demi terwujudnya amar makruf nahi munkar. Hal ini menunjukkan keselarasan antara Perda dengan Siyasah Dusturiyah berdasarkan prinsip persamaan (musawwah).Kata Kunci : Siyasah Dusturiyah, Hak Politik Perempuan, Perda
Pengaruh Penggunaan Media Lottery Card Terhadap Pencapaian Kemampuan Koneksi Matematik Siswa Smp Pada Pokok Bahasan Segiempat
Authors: Safitri W A
Published: July 2019

Tujuan dari penelitian ini adalah untuk mengetahui aktivitas guru dan siswa yang menggunakan pembelajaran dengan Media Lottery Card berkelompok dan pembelajaran dengan media Lottery Card berpasangan, perbedaan peningkatan kemampuan koneksi matematik siswa, sikap siswa terhadap pembelajaran yang menggunakan Media Lottery Card berkelompok dengan pembelajaran yang menggunakan media Lottery Card berpasangan. Metode yang digunakan dalam penelitian ini adalah metode penelitian eksperimen. Hasil penelitian (a) Persentase aktivitas guru yang menggunakan pembelajaran dengan media Lottery Card berkelompok mengalami peningkatan sebesar 26%. Persentase aktivitas guru yang menggunakan pembelajaran dengan media Lottery Card berpasangan mengalami peningkatan dari 57% menjadi 78,6%. Persentase aktivitas siswa yang menggunakan yang menggunakan pembelajaran dengan media Lottery Card berkelompok mengalami peningkatan dari 54% menajdi 82%. Persentase aktivitas siswa yang menggunakan yang menggunakan pembelajaran dengan media Lottery Card berpasangan mengalami peningkatan dari 54% menajdi 82%. (b) terdapat perbedaan peningkatan kemampuan koneksi matematik siswa antara yang menggunakan pembelajaran konvensional, pembelajaran dengan media Lottery Card berkelompok dan yang menggunakan pembelajaran dengan media Lottery Card berpasangan. (c) Sikap siswa yang menggunakan pembelajaran dengan media Lottery Card berkelompok bersikap positif sedangkan sikap siswa yang menggunakan pembelajaran dengan media Lottery Card berpasangan bersikap negatif
Penerapan Model Knisley untuk Meningkatkan Pemecahan Masalah Matematik Siswa
Authors: Purnamasari Wulan
Published: July 2019

Penelitian ini merupakan penelitian quasi eksperimen yang dilakukan di kelas VII SMPN 51 Bandung. Penelitian ini bertujuan untuk menelaah: gambaran pembelajaran matematika siswa dan guru yang menggunakan model pembelajaran matematika Knisley melalui tugas terstruktur dan tugas biasa, perbedaan peningkatan kemampuan pemecahan masalah matematika siswa yang menggunakan model pembelajaran matematika Knisley melalui tugas terstruktur, tugas biasa dan pembelajaran konvensional, kualitas peningkatan model pembelajaran matematika Knisley melalui tugas terstruktur dan model pembelajaran matematika Knisley melalui tugas biasa, serta sikap siswa terhadap pembelajaran matematika yang menggunakan model pembelajaran matematika Knisley melalui tugas terstruktur dan melalui tugas biasa. Metode penelitian yang digunakan adalah metode berbentuk Nonequivalent (Pretest dan Posttest) Control Group Design. Data yang diperoleh menggunakan instrumen penelitian berupa tes dan nontes. Setelah dilaksanakan observasi dan dianalisis. Berdasarkan hasil pengolahan data, diperoleh: gambaran aktivitas siswa dan guru mengalami peningkatan menjadi semakin baik, terdapat perbedaan kemampuan pemecahan masalah matematika siswa yang menggunakan model pembelajaran matematika Knisley melalui tugas terstruktur, model pembelajaran matematika Knisley dan pembelajaran konvensional, kualitas peningkatan yang diperoleh yaitu kualitas rendah, serta siswa memberikan respon positif terhadap pembelajaran matematika menggunakan model pembelajaran matematika Knisley
18F-FES PET/CT Influences the Staging and Management of Patients with Newly Diagnosed Estrogen Receptor-Positive Breast Cancer: A Retrospective Comparative Study with 18F-FDG PET/CT
Authors: Liu Cheng , Gong Chengcheng , Liu Shuai , Zhang Yingjian , Zhang Yongping , Xu Xiaoping , Yuan Huiyu , Wang Biyun , Yang Zhongyi
Published: July 2019

Purpose

We compared the clinical value of 16a-18F-fluoro-17b-estradiol (18F-FES) positron emission tomography (PET)/computed tomography (CT) and 18F-fluoro-2-deoxy-D-glucose (18F-FDG) PET/CT and investigated whether and how 18F-FES PET/CT affects the implemented management of newly diagnosed estrogen receptor positive breast cancer patients.

Materials and Methods

We retrospectively analyzed 19 female patients newly diagnosed with immunohistochemistry-confirmed estrogen receptor (ER)-positive breast cancer who underwent 18F-FES and 18F-FDG PET/CT within 1 week in our center. The sensitivity of 18F-FES and 18F-FDG in diagnosed lesions were compared. To investigate the definite clinical impact of 18F-FES on managing patients with newly diagnosed ER positive breast cancer, we designed two kinds of questionnaires. Referring physicians completed the first questionnaire based on the 18F-FDG report to propose the treatment regime, and the second was completed immediately after reviewing the imaging report of 18F-FES to indicate intended management changes.

Results

In total, 238 lesions were analyzed in 19 patients with newly diagnosed ER-positive breast cancer. Lesion detection was achieved in 216 sites with 18F-FES PET and in 197 sites with 18F-FDG PET/CT. These results corresponded to sensitivities of 90.8% for 18F-FES versus 82.8% for 18F-FDG PET/CT in diagnosed lesions. Thirty-five physicians were given the questionnaires referring to the treatment strategy, with 27 of them completing both questionnaires. The application of 18F-FES in addition to 18F-FDG PET/CT changed the management in 26.3% of the 19 patients with newly diagnosed ER-positive breast cancer.

Conclusion

Performing 18F-FES PET/CT in newly diagnosed ER-positive breast cancer patients increases the value of diagnosis equivocal lesions and treatment management compared with 18F-FDG PET/CT.

Implications for Practice

This study investigated whether 16a-18F-fluoro-17b-estradiol (18F-FES) positron emission tomography (PET)/computed tomography (CT) affects the clinical management of patients with newly diagnosed estrogen receptor (ER)-positive breast cancer. Physicians completing two questionnaires comparing the clinical impact of 18F-FES and 18F-FDG on individual management plans in patients with newly diagnosed ER-positive breast cancer confirmed that 18F-FES scans led to change in management in 26.3% of the 19 patients with newly diagnosed ER positive breast cancer. This retrospective study indicates the potential impact of 18F-FES PET/CT on intended management of patients with newly diagnosed estrogen receptor positive breast cancer in comparison to 18F-fluoro-2-deoxy-D-glucose PET/CT.
Aerial map demonstrates erosional patterns and changing topography at Isimila, Tanzania (with corrigendum)
Authors: Bergstrom Kersten , Lawrence Austin B. , Pelissero Alex J. , Hammond Lauren J. , Maro Eliwasa , Bunn Henry T. , Musiba Charles M.
Published: July 2019

Isimila is a Middle Pleistocene archaeological site located in southern Tanzania. The site is known for large surface assemblages of later Acheulean lithics such as hand axes, cleavers, scrapers and cores. While hominin remains have yet to be discovered at the site, Isimila offers a unique window into Middle Pleistocene Homo behaviour. Although Isimila has been studied extensively, the last published map of the site and surrounding area was made available in the 1970s. Here, we present an updated high-resolution map of Isimila. Data for the map were collected during aerial survey with an uncrewed(unmanned) aerial vehicle. With this map, we identified new archaeological localities, erosional patterns, newly exposed geological features and changes in site topography. The map demonstrates patterns of stone tool and raw material distribution that may support previous hypotheses of short-distance raw material transport into the area by hominins. This open-access map establishes a baseline for tracking changes to site topography in the future and serves as a unique tool to enable collaboration between researchers, museum personnel and local populations to better conserve Isimila.
Significance:

New potential archaeological localities and significant changes to erosional patterns at Isimila were identified.
The open access map and associated raw data provided enable researchers to track seasonal and erosional changes and anthropogenic effects, and to develop protocols for conservation of this unique site.

Open data set: 
https://doi.org/10.5281/zenodo.1470770
Experiencias de lectura literaria en educación básica: Papelucho de Marcela Paz, un estudio de caso
Authors: Troncoso Araos Ximena , Navarro Carvallo Macarena
Published: July 2019

El objetivo de esta investigación es describir experiencias de lectura literaria en educación básica, focalizándose en la obra Papelucho, de Marcela Paz, el mayor clásico de la literatura infantil chilena. La metodología aplicada es cualitativa, de diseño descriptivo interpretativo. Se realizaron cinco sesiones de lectura y diálogo sobre uno de los libros de la serie y una entrevista grupal. La información se recogió a través de registros fílmicos, registros de audio y documentos escritos, cuyos contenidos se analizaron con una matriz que contempló aspectos literarios y fases del proceso lector. Los resultados de la investigación se sintetizaron en tres aspectos: lenguaje literario, humor y valoración del libro. Estos evidenciaron la actualidad y trascendencia de la obra por las experiencias de lectura que generó en las estudiantes, quienes comprendieron y se identificaron con el lenguaje, disfrutaron del humor en distintas modalidades y empatizaron con el personaje protagónico. Tales experiencias confirman también que una obra de calidad literaria pertinente al mundo de los lectores puede contribuir a que desarrollen lecturas ricas en sentido y que despierten su interés.
Japan Latin America Relations Then and Now - The Japan Model of Economic Engagement: Opportunities for Latin America and The Caribbean
Authors: Kuwayama Mikio
Published: July 2019

This report has been prepared by Mikio Kuwayama, Managing Director of the Japan Association of Latin America and the Caribbean (JALAC) and Senior Analyst of JALAC’s Institute for Latin American and the Caribbean Studies (ILAC), for the occasion of the Seminar “Japan-Latin America Relations: Then and Now”, cohosted by the Inter-American Dialogue (IAD), September 16-17, 2015, Washington, D.C., USA.
Café Colombiano en China Oportunidades y Desafíos
Authors: Jímenez Posada Mateo , Arango Roldán María , Gómez Gómez Laura , Gómez Cataño Lorena , Palacios Ramírez Gabriela , Restrepo Campuzano Andrés , Toro Restrepo Sebastián , Vásquez Ochoa Manuela
Published: July 2019

El presente artículo busca explorar las oportunidades de negocios, así como ampliar la visión sobre China como mercado potencial para el café colombiano. Esta publicación hace parte de la divulgación de los resultados de la investigación del Semillero de Investigación de Asia Pacífico en el 2014, la cual fue dividida en dos partes. La primera parte, fue publicada en la edición pasada, incluyó un análisis de la economía de China, de su mercado de bebidas calientes, su producción cafetera y las importaciones de dicho producto. En esta segunda parte,se exponen las principales tendencias del consumidor chino, así como dos modelos (e-commerce y manufactura) para la penetración exitosa del café colombiano en el mercado chino. Este documento realiza también un análisis DOFA (debilidades, oportunidades, fortalezas y amenazas) para evaluar las posibilidades de lograr un mayor posicionamiento del café colombiano en ese mercado.
México: tan cerca de Estados Unidos como de Asia Pacífico
Authors: Ríos Ballesteros Kamila Andrea
Published: July 2019

El rápido crecimiento económico, desarrollo industrial y alto nivel de competitividad han hecho de Asia Pacífico una de las regiones más dinámicas y, por ende, prometedoras del nuevo siglo. Paralelamente, México, se ha caracterizado por ser un país con un músculo económico importante y con buenas proyecciones; sin embargo, los cambios derivados del traspaso de poder de un partido a otro a finales del año 2000, provocaron un cambio en su accionar internacional. En este sentido, el interés de este artículo es analizar la reorientación de la política económica y comercial mexicana en Asia Pacífico, mediante la implementación de la diplomacia económica entre el 2000 y 2012 y los aspectos más relevantes que resultaron de la implementación de la diplomacia económica, como acuerdos comerciales, memorándum de entendimiento, entre otros.
Cocina coreana: tradición centenaria a la vanguardia
Authors: Zuleta Zea Daniela
Published: July 2019

El siguiente documento procura introducir información básica sobre la cocina coreana y cómo sus expresiones más antiguas han cobrado hoy en día gran relevancia en el escenario mundial, comenzando desde la historia de los elementos culinarios más característicos de Corea y cómo tomaron la importancia que tienen actualmente. Finalmente, se resalta el kimchi como referente para mostrar la posibilidad que tiene una nación de tomar posiciones privilegiadas fuera de sus fronteras nacionales utilizando su cultura alimenticia como herramienta para dicho fin. Se concluye con una invitación al lector para explorar la unión cultural entre Corea y Latinoamérica a través de sus cocinas.
Buenas prácticas de sostenibilidad financiera: El caso del desarrollo acelerado de las organizaciones no lucrativas coreanas
Authors: Acosta Santamaría Dayanne Alejandra , Betancur Marín Jenny Carolina
Published: July 2019

El éxito de las Beyoungri Danche depende de las estrategias financieras que sus líderes utilizan para hacerlas sostenibles en el tiempo. La recopilación de buenas prácticas de las Beyoungri Danche coreanas en la literatura y una investigación exploratoria de contenidos web de tres organizaciones exitosas, permite aprender tácticas de otra cultura que ha demostrado un alto nivel organizacional y fortalecer el diálogo alrededor de un tema de interés común.
Encadenamientos productivos en el sureste de Asia: integración a las redes globales con empresas locales
Authors: López Aymes Juan Felipe
Published: July 2019

El artículo presenta un panorama general de las políticas industriales en el Sureste de Asia y sus implicaciones en la formación de aglomeraciones económicas y el encadenamiento de empresas locales en procesos internacionales de producción. Se destacan las diferentes formas de asimilación del capitalismo en la región y las trayectorias de industrialización que determinan su vinculación con el capital internacional. Singapur destaca como un caso de éxito en la inserción al proceso productivo internacional gracias a su política industrial. En el caso extremo, Tailandia también se propuso desarrollar clusters industriales para atraer capital y desarrollar industria nacional, pero las políticas nacionalistas y la concentración económica inhibieron ese propósito. Malasia y Vietnam son casos intermedios de éxito en el aprovechamiento de las cadenas y redes de producción internacional, pero todavía deben impulsar maneras de desarrollar tecnología propia que les permita reducir la dependencia a las empresas transnacionales. El reto principal de estos países es la formación de capital humano para integrarse a las etapas de creación de valor y evadir las desventajas de la fragmentación del capitalismo global.
Floricultura colombiana en contexto: experiencias y oportunidades en Asia pacífico
Authors: Manrique Ramírez Liceth Natalia
Published: July 2019

El sector floricultor colombiano ocupa el segundo puesto en las exportaciones agrícolas no tradicionales del país, después del café. Colombia posee una amplia variedad y especies de flores que le permiten atender a diferentes mercados del mundo, tanto en cantidad como en calidad de los productos. Al enfocarse en Asia Pacífico, este artículo presenta un panorama general del comercio de flores a nivel global, para luego identificar las particularidades, fortalezas y amenazas del sector colombiano y los mecanismos de integración que podrían beneficiar el comercio con los mercados asiáticos. Finalmente se analizará el caso de tres empresas floricultoras, que han construido relaciones de comercio exitosas con Asia.
Arabidopsis growth medium with varying sulfur and nitrogen content v1
Authors: Burow Meike
Published: July 2019

Media receipe to grow A. thaliana seedlings on plates. Variaiton in S and N concentrations.
Freezing a strain of C. elegans for long-term storage v1
Authors: Riccio Cristian
Published: July 2019

Freezing down a strain of C. elegans for long-term storage. The larval stage is the best at surviving freezing. It does not make sense to freeze down post-reproductive stages as they will not give rise to new worms after defrosting.
Terpsinoë musica Ehrenberg (Bacillariophyceae), primer registro del género para Colombia
Authors: Medina-Tombé Mario Fernando , Vouilloud Amelia Alejandra , Sala Silvia Estela
Published: July 2019

En este trabajo se presenta el primer registro de la especie Terpsinoë musica y la primera cita del género para Colombia. Los especímenes de T. musica se estudiaron mediante microscopía óptica y electrónica de barrido, se realizó la descripción morfológica y se tomaron los datos morfométricos. Esta alga fue encontrada en muestras de perifiton recolectadas en sistemas lóticos de las regiones biogeográficas de la Orinoquía y el Caribe, asociada a Eichhornia crassipes y Lenna minor, en cuerpos de agua levemente alcalinos, con conductividades eléctricas moderadas y bajos valores de caudal. Se realizó una comparación con otras poblaciones de la especie registradas en América, Europa y África, mencionando aspectos relacionados con sus requerimientos ecológicos y distribución geográfica. El material tipo de la especie no ha sido analizado con técnicas modernas de estudio. Teniendo en cuenta la gran variabilidad morfológica entre distintas poblaciones de la especie y la diversidad de ambientes en los que se registró, se plantea si estamos frente a un taxón con amplia variabilidad morfológica y gran distribución geográfica o, por el contrario, si se trata de un complejo de especies con requerimientos ecológicos y distribuciones más restringidas.
Immunohistochemical Expression of PTCH1 and Laminin in Oral Hyperplastic, Premalignant, Squamous Cell Carcinoma and Recurrence Lesions Samples
Authors: Hamaamin Kanar , Hussein Falah , Mohammad Dena
Published: July 2019

Objective: Laminin is a basal membrane glycoprotein that showed progressive loss of continuity from dysplasia to invasive carcinoma. The membranous receptor Patched (PTCH1) promotes the nuclear translocation and activation of the Gli family proteins. The dysregulation of hedgehog signaling reported in various cancers. This study aims to assess the immunohistochemical expression of PTCH1 and laminin in different groups of lesions of oral hyperplastic, premalignant, oral squamous cell carcinoma (OSCC) and recurrence cases.       

Methods: This study involved 35 paraffin blocks of 4 oral hyperplastic, 11 premalignant, 15 OSCC and five recurrences OSCC cases collected from Sulaimani Histopathological Centers. Prepared tissue sections were stained immunohistochemically for both PTCH1 and laminin antibodies and scored. Chi-square correlations used and the p 0.05 considered as statistically significant. 

Results: PTCH1 showed expression in all oral hyperplastic lesions. While 81.8% of oral premalignant lesions demonstrated basal and parabasal distribution with high mixed localization (72.7%), lastly 93.3% of OSCC showed positive expression and mainly found within score 2(46.6%). No significant relations detected between oral hyperplastic and premalignant lesions regarding the expression pattern, localization and intensity as p-values were 0.77, 0.09 and 0.38 respectively. Lastly, the relations between OSCC and recurrent cases to both the expression and localization parameters were non-significant, as p-values were 0.15 and 0.09, respectively. Laminin showed continuous expression at the basement membrane of the normal oral mucosa, while only (50%) of the cases revealed such expression in oral hyperplastic lesions. The oral premalignant lesions expressed 54.5% of a discontinuous pattern. The relation between the oral hyperplastic and premalignant lesions in response to laminin expression was non-significant (P=.21).  A significant relation found in laminin expression between OSCC and recurrence samples (p= 0.02). Finally, a significant correlation found between PTCH1 localization and laminin expression in oral premalignant lesions (p = 0.03).

Conclusions: The PTCH1 overexpression in all of the studied groups of lesions might give an impression of the active role of this biomarker in the progression toward malignancy. Laminin defragmentation, which started from dysplastic lesions extending to OSCC, could emphasize the role of this marker from the early precancerous stage. Furthermore, the combined PTCH1 mixed localization with discontinuous laminin expression might have a significant role in the progression of dysplastic lesions toward cancers.
Features of Seismic Sequences Are Similar in Different Crustal Tectonic Regions
Authors: Stallone Angela , Marzocchi Warner
Published: July 2019

We investigate the existence of possible differences in the earthquake clustering process in three areas related to distinct tectonic regimes: Italy, southern California, and Japan. At first, we separate the triggered and background components of seismicity of the three catalogs. Then, we analyze statistically the space–time domain of the earthquake clusters to identify possible variations in the triggering properties across the considered regions. Finally, we characterize the background seismicity in the three seismic catalogs to test whether it can be satisfactorily described by a time‐homogeneous Poisson process. Overall, our analysis shows similar features of the seismicity in the three tectonic regions. Specifically, we find common average earthquake clustering properties in the three tectonic regions superimposed on a background seismicity described by the Poisson process, with a time‐dependent rate. We conclude that, at least for the analyzed active seismic crustal regions, the tectonic regime does not seem to play a key role in affecting the average spatiotemporal clustering properties. Remarkably, we reach the same conclusion when inspecting the influence of subregions with homogeneous deformation style.
Forecasting Earthquakes by Hybrid Model of Pattern Informatic and PageRank Methods
Authors: Rezaei Soghra , Moghaddasi Hanieh , Darooneh Amir Hossein , Zare Mehdi
Published: July 2019

Although there is no proven method for predicting earthquakes in a short time, it is feasible to evaluate their hazards probabilistically. Here, we aim to find active and passive places of Iran’s geographical region. In this regard, we have analyzed pattern informatic (PI) and the relative intensity methods in Iran as retrospective binary forecasting methods, and used the PageRank (PR) algorithm to rank different places. Then, we introduce a hybrid model of PR and PI methods (PR‐PI) for prediction in the earthquakes network. The results show that our method turns out to be one of the most reliable forecasts compared to other methods based on the common relative operating characteristic diagram. We have also found a regional seismogenic map where earthquakes are likely to occur during a specific time interval in the future.
Политическая повестка правительства, или зачем государству общество
Authors: Соловьев Александр
Published: July 2019

Институты государственного управления по мере разработки правительственных решений подвергаются постоянному неформальному давлению со стороны ресурсно оснащенных стейкхолдеров, встраивающихся за счет этого в фактические цепочки целеполагания. Систематическое влияние этих контрагентов, успешно преодолевающее административные барьеры, со временем формирует устойчивый кластер взаимоотношений органов власти с сетевыми политико-административными коалициями, порождая феномен “переплетенных институтов”, означающих сращивание официальных структур с ассоциациями собственников и контролеров крупных общественных ресурсов. В рамках этого комплекса деловых коммуникаций вместо публичных институтов возникают “узлы решений”, в которых, с одной стороны, формируется политическая повестка правительства, а с другой, постепенно меняется состав правящей элиты, часть которой все больше утрачивает навыки взаимодействия с обществом и представительства его интересов. В этих условиях общественная повестка теряет фактические возможности влияния на содержание государственной политики и продвижение интересов граждан. В то же время, пытаясь отстоять свои интересы, граждане апеллируют к официальным нормам и институтам, которые зачастую не имеют отношения к фактически принимаемым решениям, инициируемым сетевыми коалициями, использующими формальные институции в качестве официального прикрытия своих действий. Автор показывает, что в современном российском обществе аффилиация сетей с публичными институтами государственного управления усугублена издержками суперпрезидентской республики и существенными деформациями норм демократической организации власти. Это в еще большей степени снижает возможности общества в части влияния на цели и планы правительства.
Как создается режим: властные коалиции в сибирских городах
Authors: Пустовойт Юрий
Published: July 2019

Почему и при каких условиях в одном случае формируются режимы, ориентированные на доминирование одного актора, способного менять правила игры, а в другом возможности политических субъектов ограничены? Исследование направлено на изучение властных групп в городском сообществе, рассматриваемых в рамках концепции городских политических режимов, которые представляют собой комплекс формальных и неформальных норм взаимодействия акторов, имеющих доступ к институциализированным ресурсам и образующих коалицию для управления общностью. Первоначально в фокусе внимания были процессы формирования режима в крупном индустриальном центре, характеризующемся монополией на власть и персонификацией. Далее была сформулирована гипотеза о внешних (масштаб города, проекция интересов бизнеса и специализация предприятий) и внутренних (стратегия лидерства) факторах формирования различных режимов. Методом проверки гипотезы стало сравнение противоположных случаев: режим в индустриальном центре был сопоставлен с режимом сибирского мегаполиса. Далее сравнение проводилось в двух городских районах с противоположными социально-экономическими характеристиками. В последующем был сделан анализ власти в сибирских городах. Общими характеристиками городских режимов являются ограничения и мотивация участников. Самостоятельность акторов зависит от требований федерального (в обоих случаях) и регионального (в меньшей степени для мегаполиса) центров. Система сложившихся неформальных правил во многом совпадает с характеристиками “политической машины” и построена на личных интересах участников коалиций, а не на доминировании политических принципов и идеологий. Показаны различия в стратегиях акторов: в монопольных, персонифицированных режимах – традиционное лидерство с явно выраженной программой, концентрацией ресурсов и привлечением членов коалиции для реализации объявленных целей, в режимах полиархических – “устойчивое действие”, построенное на максимальной скрытости и неопределенности целей лидерства и заключении множества союзов с различными силами.
Мускулы войны и нервы мира: гибридная метаморфоза. Методологические и прогностические аспекты постсовременного общежития
Authors: Неклесса Александр
Published: July 2019

Гибридный мир – “большой вызов” цивилизации, комплексная проблема и одно из возможных определений мироустройства XXI века: экономика, политика, культура, война и мир, прочие групповые взаимодействия сливаются в сложноорганизованный континуум, трангрессирующий национальную государственность. Доминанта развития цивилизации сдвигается от пространственной экспансии к интенсивной колонизации земель будущего. Стратегическое преимущество переходит к системам, способным продуктивно функционировать в ситуациях неопределенности. Геополитика замещается геоэкономикой, а в подвижной среде с эластичной архитектурой доминирует социокультурная гравитация (геокультура), ускоряется перераспределение человеческих ресурсов (геоантропология). Проактивная личность, частные и партнерские институты приходят на смену скованному регламентами Левиафану. Бунт пассионариев сопрягается с восстанием элит, акцент переносится с обезличенных учреждений на мобильные сообщества, конструктивные и деструктивные, приспособленные к эффективной деятельности в условиях перманентного транзита. Цивилизационная неоднородность Ойкумены связана не только с разным уровнем социального и технологического развития, глобализация – это горизонтальное совмещение культур и конфессий, чреватое конфликтностью и десинхронизацией истории. Трансграничные сообщества, аграрные, индустриальные, постиндустриальные страны, адаптируясь к критическим обстоятельствам, различным образом реализуют потенции агрессии и обороны. Военные конфликты последнего времени происходили преимущественно в афразийской зоне нестабильности, но не только: сирийская чересполосица, подвижное “Исламское государство” (запрещенное в РФ), дестабилизированная Ливия, вооруженные столкновения в ряде других государств Африки, в Йемене, Ираке, Афганистане, а также на Донбассе. В сфере военного искусства растет значение сложных аппаратно-технических средств, неординарных концептов, управленческих инноваций, мастерства комбинаций, провоцируя, в свою очередь, технологические инициативы и социальные интервенции. Синтез военных и гражданских практик рискует утвердиться в качестве социополитической реальности и культурной нормы. Софистика гибридного мира подрывает властный консенсус и моральный императив современности, а ядерное оружие из закрывающей войну технологии может стать зонтиком для коррумпирующих мир действий. Сбой в доверии к контрактам безопасности способен привести к банкротству организации международного сообщества.