bluuebunny/crossref_metadata_2025 huggingface dataset:
Red Cell Storage Duration Does Not Affect Outcome after Massive Blood Transfusion in Trauma and Nontrauma Patients: A Retrospective Analysis of 305 Patients
Authors: Bautista Alexander , Wright Theodore B. , Meany Janice , Kandadai Sunitha K. , Brown Benjamin , Khalafalla Kareim , Hashem Saeed , Smith Jason W. , Ayyoubi Tayyeb M. , Dalton Jarrod E. , Wadhwa Anupama , Sessler Daniel I. , Obal Detlef
Published: May 2017

Background. Prolonged storage of packed red blood cells (PRBCs) may increase morbidity and mortality, and patients having massive transfusion might be especially susceptible. We therefore tested the hypothesis that prolonged storage increases mortality in patients receiving massive transfusion after trauma or nontrauma surgery. Secondarily, we considered the extent to which storage effects differ for trauma and nontrauma surgery.Methods. We considered surgical patients given more than 10 units of PRBC within 24 hours and evaluated the relationship between mean PRBC storage duration and in-hospital mortality using multivariable logistic regression. Potential nonlinearities in the relationship were assessed via restricted cubic splines. The secondary hypothesis was evaluated by considering whether there was an interaction between the type of surgery (trauma versus nontrauma) and the effect of storage duration on outcomes.Results. 305 patients were given a total of 8,046 units of PRBCs, with duration ranging from 8 to 36 days (mean ± SD:22±6days). The odds ratio [95% confidence interval (CI)] for in-hospital mortality corresponding to a one-day in mean PRBC storage duration was 0.99 (0.95, 1.03,P=0.77). The relationship did not differ for trauma and nontrauma patients (P=0.75). Results were similar after adjusting for multiple potential confounders.Conclusions. Mortality after massive blood transfusion was no worse in patients transfused with PRBC stored for long periods. Trauma and nontrauma patients did not differ in their susceptibility to prolonged PRBC storage.
Refining Automatically Extracted Knowledge Bases Using Crowdsourcing
Authors: Li Chunhua , Zhao Pengpeng , Sheng Victor S. , Xian Xuefeng , Wu Jian , Cui Zhiming
Published: May 2017

Machine-constructed knowledge bases often contain noisy and inaccurate facts. There exists significant work in developing automated algorithms for knowledge base refinement. Automated approaches improve the quality of knowledge bases but are far from perfect. In this paper, we leverage crowdsourcing to improve the quality of automatically extracted knowledge bases. As human labelling is costly, an important research challenge is how we can use limited human resources to maximize the quality improvement for a knowledge base. To address this problem, we first introduce a concept of semantic constraints that can be used to detect potential errors and do inference among candidate facts. Then, based on semantic constraints, we propose rank-based and graph-based algorithms for crowdsourced knowledge refining, which judiciously select the most beneficial candidate facts to conduct crowdsourcing and prune unnecessary questions. Our experiments show that our method improves the quality of knowledge bases significantly and outperforms state-of-the-art automatic methods under a reasonable crowdsourcing cost.
Determining the REV for Fracture Rock Mass Based on Seepage Theory
Authors: Zhang Lili , Xia Lu , Yu Qingchun
Published: May 2017

Seepage problems of the fractured rock mass have always been a heated topic within hydrogeology and engineering geology. The equivalent porous medium model method is the main method in the study of the seepage of the fractured rock mass and its engineering application. The key to the method is to determine a representative elementary volume (REV). The FractureToKarst software, that is, discrete element software, is a main analysis tool in this paper and developed by a number of authors. According to the standard of rock classification established by ISRM, this paper aims to discuss the existence and the size of REV of fractured rock masses with medium tractility and provide a general method to determine the existence of REV. It can be gleaned from the study that the existence condition of fractured rock mass with medium tractility features average fracture spacing smaller than 0.6 m. If average fracture spacing is larger than 0.6 m, there is no existence of REV. The rationality of the model is verified by a case study. The present research provides a method for the simulation of seepage field in fissured rocks.
Portal Hypertensive Biliopathy Presents with Massive Bleeding during ERCP after Balloon Sphincteroplasty in a Noncirrhotic Saudi Sickler Patient
Authors: Al-Akwaa Ahmad M. , Elsadig Mohammed , Al-Fayaa Ahmed E. , Al-Shehri Mohja D.
Published: May 2017

Portal hypertensive biliopathy (PHB) is described as abnormalities of the walls of the biliary tree secondary to portal hypertension. Gastrointestinal bleeding caused by PHB is rare. PHB as a cause of serious bleeding after sphincteroplasty during ERCP is extremely rare. Here, we report a case of PHB in a young Saudi male with cell sickle anemia who developed massive hemorrhage during ERCP after balloon dilation of the ampulla of Vater. We further discussed the diagnosis and management. To the best of our knowledge, no such case has been reported.
Brain-Derived Neurotropic Factor Val66Met Polymorphism and Posttraumatic Stress Disorder among Survivors of the 1998 Dongting Lake Flood in China
Authors: Dai Wenjie , Kaminga Atipatsa C. , Wu Xin , Wen Shi Wu , Tan Hongzhuan , Yan Junxia , Deng Jing , Lai Zhiwei , Liu Aizhong
Published: May 2017

Objective. This study mainly aimed to explore the association between brain-derived neurotropic factor (BDNF) Val66Met polymorphism and posttraumatic stress disorder (PTSD) among flood survivors in China. Methods. Individuals who experienced the 1998 Dongting Lake flood in Southeast Huarong, China, were enrolled in this study. Qualified health personnel carried out face-to-face interviews with participants. PTSD was identified using PTSD Checklist-Civilian version (PCL-C). Blood samples were collected from the participants to extract DNA for genotyping. Results. A total of 175 participants were enrolled in this study. The prevalence of PTSD among flood survivors at 17-year follow-up was 16.0% (28/175). Individuals with PTSD were more likely to be female, experience at least three flood-related stressors, experience at least three postflood stressors, and carry the Met than those without PTSD. Compared with Val/Val homozygotes, Met carriers had higher scores of PCL-C (mean ± standard error: 23.60±7.23 versus 27.19±9.48, P<0.05). Multivariable logistic regression analysis indicated that Met carriers (aOR = 4.76, 95% CI = 1.02–22.15, P<0.05) were more likely to develop PTSD than Val/Val homozygotes. Conclusions. Met carriers for BDNF rs6265 are at higher risk of developing PTSD and also exhibit more severe PTSD symptoms than Val/Val homozygotes among flood survivors in China.
Recurrent Enterolithiasis Small Bowel Obstruction: A Case Seldom Described
Authors: Shrestha Ashish Lal , Shrestha Pradita
Published: May 2017

Background. Enterolithiasis of the small bowel is a rare phenomenon in humans although it has been frequently described in equines. Primary enteroliths have been described including those occurring secondary to conditions like Crohn’s disease, small bowel diverticula, tuberculous or postoperative strictures, and blind loops but those occurring in an otherwise normal gut are exceedingly rare. Of even greater rarity is a recurrent small bowel enterolith presenting with obstruction. This may be the first report of such kind.Case Presentation. A 70-year-old man undergoing treatment for stable alcoholic liver disease presented to the emergency with gradually progressive diffuse abdominal pain associated with vomiting and constipation for 7 days. He had gaseous abdominal distention but was not obstipated. He had a history of 2 laparotomies in the past for small bowel obstruction secondary to enterolith impaction. He was initially managed conservatively but since there was no significant clinical improvement, he underwent an exploratory laparotomy. A recurrent enterolith 5 × 5 cm in size was found impacted in the mid ileum with multiple dense serosal adhesions and bands. Adhesiolysis and enterotomy with removal of enterolith were performed.Conclusion. Recurrent enterolithiasis of the small bowel is a rare phenomenon and may present with recurrent obstruction. Definitive preoperative diagnosis is not always possible and a high index of suspicion is required to avoid table misdiagnosis. Surgery is the mainstay of treatment once conservative measures fail. Laparoscopic methods may help in diagnosis and avoid possibility of a subsequent adhesive bowel obstruction but are associated with technical challenges.
Simultaneous Determination of 8 Compounds in Gancao‐Ganjiang‐Tang by HPLC‐DAD and Analysis of the Relations between Compatibility, Dosage, and Contents of Medicines
Authors: Yang Yanfang , Zhang Guijun , Sun Qiyu , Liu Liang , Peng Hui , Wang Jingjuan , Xiang Li
Published: May 2017

Gancao‐Ganjiang‐Tang (GGT) is a traditional Chinese medicine (TCM) prescription and is a representative prescription for recuperating depleted Yang in Treatise on Febrile Diseases. The TCM theory believes that the efficacy of medicinal herbs is decided by the multicompounds which consist of different kinds of chemical constituents with bioactivities, but not by a monomeric constituent. From ancient times until today, GGT have 5 different kinds of compatibilities that can be verified. In this study, a HPLC‐DAD method was established for the simultaneous determination of 8 compounds including 6‐gingerol, 8‐gingerol, 6‐shogaol, liquiritin, liquiritigenin, isoliquiritin, isoliquiritigenin, and glycyrrhizic acid in the five GGT. The total contents of the 8 compounds in GGT varied from 555.56 to 956.33 μg/mL. The effects showed that the dosage and compatibility of medicinal herbs have influenced the content of chemical compounds of TCM prescription while the content of chemical compounds has acted on clinical efficacy. Quality evaluation and active essence screening of TCM (including single herb and prescription) should be based on the TCM theory and clinical effectiveness. The method was proven to be suitable for quality control of GGT.
Postoperative Echocardiographic Reduction of Right Ventricular Function: Is Pericardial Opening Modality the Main Culprit?
Authors: Zanobini Marco , Saccocci Matteo , Tamborini Gloria , Veglia Fabrizio , Di Minno Alessandro , Poggio Paolo , Pepi Mauro , Alamanni Francesco , Loardi Claudia
Published: May 2017

Echocardiographic reduction of RV function, measured using TAPSE, is a well described phenomenon after cardiac surgery. The aim of the present study was to investigate the relation between the modality of pericardial opening (lateral versus anterior) and the postoperative right ventricular systolic function by comparing echocardiographic parameters in patients undergoing minimally invasive or traditional mitral valve repair. 34 patients with severe mitral regurgitation due to mitral valve prolapse underwent traditional (sternotomy) operation (Group A) or minimally invasive surgery with right anterolateral thoracotomy (Group B). A postoperative TAPSE fall was found in both groups. Group A experienced a significant postoperative TAPSE fall versus Group B withp<0.0001.
Native Valve Endocarditis due toVeillonellaSpecies: A Case Report and Review of the Literature
Authors: Saladi Lakshmi , Zeana Cosmina , Singh Manisha
Published: May 2017

Veillonellaspecies are fastidious bacteria that have been isolated from skin, dental, and respiratory tract infections and rarely have been implicated in serious infections like meningitis, endocarditis, and osteomyelitis. A 76-year-old woman presented to our hospital with fever, vomiting, and generalized weakness for 3 days. A transthoracic echocardiogram showed a mobile structure on anterior mitral valve leaflet measuring 0.9 cm suggestive of vegetation. Empiric therapy with vancomycin and piperacillin-tazobactam was started with clinical resolution of her symptoms. On day 6, the blood culture drawn at admission grewVeillonellaspecies. A transesophageal echocardiogram confirmed a 1.2×0.4 cm echo dense structure attached to the left ventricular side of the anterior mitral leaflet. The patient was discharged home after 10 days of inpatient antibiotic therapy and completed 4 weeks of IV ceftriaxone at home without any adverse events. She was reevaluated in the clinic after completion of treatment and repeat blood cultures remained negative. We report the first case of successful treatment of endocarditis due toVeillonellaspecies with once daily ceftriaxone.
Effectiveness of Positive Thinking Training Program on Nurses’ Quality of Work Life through Smartphone Applications
Authors: Motamed-Jahromi Mohadeseh , Fereidouni Zhila , Dehghan Azizallah
Published: May 2017

Aim. Job stress is a part of nurses’ professional life that causes the decrease of the nurses’ job satisfaction and quality of work life. This study aimed to determine the effect of positive thinking via social media applications on the nurses’ quality of work life. Methods. This was a pretest-posttest quasi-experimental study design with a control group. The samples were selected among the nurses in two hospitals in Fasa University of Medical Sciences and divided randomly into two interventional (n=50) and control (n=50) groups. Positive thinking training through telegrams was sent to the intervention group during a period of 3 months. Data were collected by using Brooks and Anderson’s questionnaire of work life quality and analyzed by SPSS 18. Results. The mean total scores of pretest and posttest in the intervention group improved noticeably and there were significant differences between mean scores of quality of work life in pretest and posttest scores in interventional groups (p<0.001) and in dimensions of work life quality, home life (p<0.001), work design (p<0.001), work context (p<0.001), and work world (p=0.003). Conclusion. This study concluded that positive thinking training via social media application enhanced nurses’ quality of work life. This study is necessary to carry out on a larger sample size for generalizing findings better.
The Portfolio Balanced Risk Index Model and Analysis of Examples of Large-Scale Infrastructure Project
Authors: Gao Wu , Hong Kairong
Published: May 2017

This paper focuses on a three-dimensional portfolio balanced risk index model for large-scale infrastructure project risk evaluation as a hot topic of current research. Taking subjectivity utility and complex evaluation motivation into consideration, a method of combinational equilibrium evaluation is built using the index form to reflect whole loss changes of risk. For risk index evaluation and measurement issues, this paper first constructs a risk evaluation index system and three risk coefficients of single factor by questionnaire survey and fuzzy evaluation. Then we calculate the risk index of single factor, which arrives at the classification and combination risk index through AHP method. Finally, we verify the index validity by analysis of examples. With this research we expand the evaluation dimension and provide a new analytical tool for risk monitoring and warning.
A Review of Sensing Strategies for Microwave Sensors Based on Metamaterial-Inspired Resonators: Dielectric Characterization, Displacement, and Angular Velocity Measurements for Health Diagnosis, Telecommunication, and Space Applications
Authors: Su Lijuan , Mata-Contreras Javier , Vélez Paris , Martín Ferran
Published: May 2017

Four sensing approaches for the implementation of microwave sensors based on transmission lines loaded with metamaterial-inspired resonators are considered in this review paper, and examples of applications are pointed out. In all the cases, sensing is based on the effects that the magnitude under measurement causes in the transmission properties of the resonator-loaded line. Such four strategies are (i) resonance frequency variation, (ii) coupling modulation through symmetry disruption (causing variation of the notch depth), (iii) frequency splitting (also exploiting symmetry properties), and (iv) amplitude modulation of a harmonic signal. Such sensors are useful in various scenarios, of interest in fields as diverse as characterization of dielectric materials for communication circuits, medical diagnosis and treatment with microwave technologies, and sensors for space applications, among others.
Inhibition of α-Amylases by Condensed and Hydrolysable Tannins: Focus on Kinetics and Hypoglycemic Actions
Authors: Kato Camila Gabriel , Gonçalves Geferson de Almeida , Peralta Rosely Aparecida , Seixas Flavio Augusto Vicente , de Sá-Nakanishi Anacharis Babeto , Bracht Lívia , Comar Jurandir Fernando , Bracht Adelar , Peralta Rosane Marina
Published: May 2017

The aim of the present study was to compare the in vitro inhibitory effects on the salivary and pancreatic α-amylases and the in vivo hypoglycemic actions of the hydrolysable tannin from Chinese natural gall and the condensed tannin from Acacia mearnsii. The human salivary α-amylase was more strongly inhibited by the hydrolysable than by the condensed tannin, with the concentrations for 50% inhibition (IC50) being 47.0 and 285.4 μM, respectively. The inhibitory capacities of both tannins on the pancreatic α-amylase were also different, with IC50 values being 141.1 μM for the hydrolysable tannin and 248.1 μM for the condensed tannin. The kinetics of the inhibition presented complex patterns in that for both inhibitors more than one molecule can bind simultaneously to either the free enzyme of the substrate-complexed enzyme (parabolic mixed inhibition). Both tannins were able to inhibit the intestinal starch absorption. Inhibition by the hydrolysable tannin was concentration-dependent, with 53% inhibition at the dose of 58.8 μmol/kg and 88% inhibition at the dose of 294 μmol/kg. For the condensed tannin, inhibition was not substantially different for doses between 124.4 μmol/kg (49%) and 620 μmol/kg (57%). It can be concluded that both tannins, but especially the hydrolysable one, could be useful in controlling the postprandial glycemic levels in diabetes.
Cavity Formation Modeling of Fiber Fuse in Single-Mode Optical Fibers
Authors: Shuto Yoshito
Published: May 2017

The evolution of a fiber-fuse phenomenon in a single-mode optical fiber was studied theoretically. To clarify both the silica-glass densification and cavity formation, which have been observed in fiber fuse propagation, we investigated a nonlinear oscillation model using the Van Der Pol equation. This model was able to phenomenologically explain both the densification of the core material and the formation of periodic cavities in the core layer as a result of a relaxation oscillation.
A Case of Chronic Ectopic Pregnancy Manifested by Rectal Bleeding
Authors: Vukas Radulovic Nina , Bullarbo Maria , Ekerhovd Erling
Published: May 2017

Ectopic pregnancy resulting in perforation of the rectum and rectal bleeding is clinically rare. We report an extremely rare case of chronic ectopic pregnancy with decreasing low levels of serum β-HCG resulting in rectal bleeding. A 31-year-old woman, gravida 3, para 3, with moderate abdominal pain and rectal bleeding was diagnosed with a tubal pregnancy. The tube was adherent to the rectum. Following salpingo-oophorectomy, the perforation of the rectum was sutured. Biopsies from the rectum as well as the tube confirmed chronic ectopic pregnancy. This case illustrates that diagnosing ectopic pregnancy is sometimes extremely challenging and it underlines the importance of follow-up consultations when the final diagnosis has not yet been reached.
Surrounding Rock Deformation Mechanism and Control Technology for Gob-Side Entry Retaining with Fully Mechanized Gangue Backfilling Mining: A Case Study
Authors: Gong Peng , Ma Zhanguo , Zhang Ray Ruichong , Ni Xiaoyan , Liu Fei , Huang Zhimin
Published: May 2017

To counter the technical difficulties faced by gob-side entry retaining (GER) under multiple complex mining geological conditions in China, this paper introduces a GER method with fully mechanized gangue backfilling mining. A similar materials simulation experiment was conducted to simulate the gob-backfilled GER process by using the similar model test system containing an independently developed horizontal pushing load device. The experimental results show that the compaction speed of the backfilling area (BFA) can be improved, and the main roof subsidence can be reduced by increasing the horizontal pushing load and reducing the attenuation rate of the stress in BFA. The designed roadside backfill body (RBB) containing a flexible cushion is adaptive to the given deformation of the main roof, thus reducing the stress concentration of the RBB. The field test results show that when a 2 MPa horizontal pushing load is exerted in the BFA, arranging a 200 mm high-water-material flexible cushion can cause the BFA to swiftly change to the compaction stage. After stabilized deformation, the roadway section satisfies the design and application requirements. The feasibility and rationality of the GER with the fully mechanized gangue backfilling mining are proved, providing a safe, efficient, and environmentally friendly mining method without using a coal pillar.
Modeling Road Network Vulnerability for Evacuees and First Responders in No-Notice Evacuation
Authors: Chen Xiang , Li Qiang
Published: May 2017

The concept of vulnerability has been employed to develop transport systems that sustain devastating disasters and ensure the efficient evacuation of neighborhoods. Existing studies of road network vulnerability overlook two important aspects of analysis: the no-notice evacuation and the different objectives of evacuees and first responders. First, a no-notice evacuation leaves limited time for proactive emergency planning; therefore, rescue strategies in this scenario rely heavily on real-time traffic information. Second, the goal of first responders in an evacuation is to move into an affected area immediately after a hazardous event unfolds, and the risk they face differs from that of evacuees. To this end, this paper develops a network-based model to evaluate vulnerability during a no-notice evacuation and applies it to a case study in Dublin, OH, USA. The model is suited to assessing network vulnerability in response to events with uncertainty and coordinating traffic control strategies in a no-notice evacuation. This study can become a valuable complement to the methodological conceptualization of vulnerability and can provide insights into developing comprehensive emergency management plans.
County Smoke-Free Laws and Asthma Discharges: Evidence from 17 US States
Authors: Landers Glenn M. , Ketsche Patricia , Diana Mark L. , Campbell Claudia
Published: May 2017

Background. Although approximately 82 percent of the US population was covered by some form of law that restricted smoking in public establishments as of 2014, most research examining the relationship between smoke-free laws and health has been focused at the state level.Purpose. To examine the effect of county workplace smoke-free laws over and above the effect of other (restaurant or bar) smoke-free laws on adult asthma.Methods. The study estimated the effect of rates of adult asthma discharges before and after the implementation of county nonhospitality workplace smoke-free laws and county restaurant and bar smoke-free laws. Data were from 2002 to 2009, and all analyses were performed in 2011 through 2013.Results. A statistically significant relationship (−5.43,p<.05) was found between county restaurant or bar smoke-free laws and reductions in working age adult asthma discharges. There was no statistically significant effect of nonhospitality workplace smoke-free laws over and above the effect of county restaurant or bar laws.Conclusions. This study suggests that further gains in preventable asthma-related hospitalizations in the US are more likely to be made by focusing on smoke-free laws in bars or restaurants rather than in nonhospitality workplaces.
Facile Synthesis of ZnxCd1-xS Solid Solution Microspheres through Ultrasonic Spray Pyrolysis for Improved Photocatalytic Activity
Authors: Huang Jianhui , Lin Wenting , Xie Liyan , Ho Wingkei
Published: May 2017

Nanocrystal ZnxCd1-xS solid solutions were successfully prepared using a facile and reproducible method of ultrasonic spray pyrolysis with Cd(Ac)2·2H2O, ZnCl2, and thiourea as precursors. Scanning electron microscopy and transmission electron microscopy images show that the prepared particles possess microspherical morphology. The band gaps of the solid solutions can be tuned by changing the constituent stoichiometries of Cd and Zn. The X-ray diffraction peaks gradually shift to small angle, and the absorption edge shifts to long wavelength with increasing Cd molar fraction in the solid solution. The sample prepared at the Cd/Zn ratio of 1 : 1 displays the optimal activity by using the photocatalytic degradation of methyl orange in the aqueous solution as model reactions under visible light irradiation. This study provides an effective route to prepare spherical ternary photocatalysts with mesoporous structure for further investigations and practical applications.
Asymmetric Dimethylarginine Induced Apoptosis and Dysfunction of Endothelial Progenitor Cells: Role of Endoplasmic Reticulum Stress Pathway
Authors: Ye Sheng , Zhou Xi , Lin Jiafeng , Chen Peng
Published: May 2017

Asymmetric dimethylarginine (ADMA), an inhibitor of nitric oxide synthase, is a novel risk factor of cardiovascular disease. Endothelial progenitor cells (EPCs) bear typical endothelial characteristics and are thought to contribute to neovascularization by providing new endothelial cells (ECs) after arterial injury. Many studies have shown that ADMA can induce EPC apoptosis and dysfunction, but the underlying mechanism is not well understood. EPCs from umbilical cord blood were cultured in EGM-2 medium with particular growth factors and supplemented with 10% fetal bovine serum. The cells were treated with different concentrations of ADMA (5, 10, and 50 μmol/L). Endoplasmic reticulum (ER) stress marker levels were examined by western blot analysis. After 24-hour incubation, ADMA induced apoptosis of EPCs and significantly decreased the proliferation, migration, and vasculogenesis capacity of EPCs. We also found that ADMA treatment activated phosphorylated protein kinase RNA-activated-like ER kinase (PERK), a stress sensor protein in the endoplasmic reticulum (ER). The activated PERK induced 78 kDa glucose-regulated protein (GRP-78) and C/EBP homologous protein (CHOP) expression. Additionally, the inhibition of the ER stress pathway by Salubrinal (a specific ER stress inhibitor) can attenuate ADMA-induced apoptosis of EPCs. Overall, these observations indicate that ADMA may induce the apoptosis and dysfunction of EPCs through the ER stress pathway.
Elephantorrhiza elephantina: Traditional Uses, Phytochemistry, and Pharmacology of an Important Medicinal Plant Species in Southern Africa
Authors: Maroyi Alfred
Published: May 2017

Elephantorrhiza elephantina is used in southern Africa as traditional remedy for a wide range of human diseases and ailments including dermatological diseases, gastrointestinal system disorders, sexual dysfunction, sexually transmitted infections, and wounds. The rhizome decoction of E. elephantina is widely used by small‐scale farmers in Botswana and South Africa as ethnoveterinary medicine for cattle, goats, horses, pigs, poultry, and sheep. Several classes of phytochemical compounds including anthocyanidins, anthraquinones, esters, fatty acids, phenolic compounds, flavonoids, glycosides, polysterols, saponins, sugars, tannins, and triterpenoids have been isolated from E. elephantina. Scientific studies on E. elephantina indicate that it has a wide range of biological activities including anthelmintic, antibacterial, antifungal, anti‐inflammatory and antinociceptive, antiplasmodial, antioxidant, antibabesial, and antirickettsial activities. Elephantorrhiza elephantina is a valuable source of traditional medicine in southern Africa that it is worth additional research attention because of its wide ethnomedicinal applications and promising biological activities. However, the current health‐related information on E. elephantina is not sufficiently explored as diverse studies on its chemical and pharmacological activities are required to understand its mechanism of action and to characterize the metabolites responsible for these activities.
Outcomes of Six-Dose High-Dose Cytarabine as a Salvage Regimen for Patients with Relapsed/Refractory Acute Myeloid Leukemia
Authors: Anders Brandi , Veltri Lauren , Kanate Abraham S. , Shillingburg Alexandra , Shah Nilay , Craig Michael , Cumpston Aaron
Published: May 2017

Relapsed/refractory acute myeloid leukemia (RR-AML) is associated with poor prognosis and long-term disease-free survival requires allogeneic hematopoietic cell transplantation (allo-HCT). Limited data exists, regarding the optimal regimen to obtain remission prior to allo-HCT. Single agent high-dose cytarabine (10–12 doses administered every 12 hours) has been previously used as induction therapy. Six-dose high-dose cytarabine (HiDAC-6), commonly used as a consolidation regimen, has never been evaluated as induction therapy. We present a retrospective review of 26 consecutive patients with RR-AML receiving single agent cytarabine 3 g/m2intravenously every 12 hours on days 1, 3, and 5 for a total of six doses (HiDAC-6). Median follow-up for surviving patients was 10.4 months (range 1.6–112.2 months). Complete remission was obtained in 62% (54% CR and 8% CRi) of the patients. The median relapse-free survival (RFS) was 22.3 months (range 0.7–112 months), event-free survival (EFS) was 4.7 months (range 0.5–112 months), and the overall survival (OS) was 9.6 months (range 1–112 months). Thirty-five percent of patients were able to subsequently proceed to allo-HCT. Treatment-related toxicities included neutropenic fever (38%), infection (35%), neurotoxicity (8%), and skin toxicity (8%). This is the first study to demonstrate HiDAC-6 as an active treatment option for younger patients with RR-AML which can effectively serve as a bridge to allo-HCT without significant toxicity.
A Reinforcement Learning Approach to Access Management in Wireless Cellular Networks
Authors: Moon Jihun , Lim Yujin
Published: May 2017

In smart city applications, huge numbers of devices need to be connected in an autonomous manner. 3rd Generation Partnership Project (3GPP) specifies that Machine Type Communication (MTC) should be used to handle data transmission among a large number of devices. However, the data transmission rates are highly variable, and this brings about a congestion problem. To tackle this problem, the use of Access Class Barring (ACB) is recommended to restrict the number of access attempts allowed in data transmission by utilizing strategic parameters. In this paper, we model the problem of determining the strategic parameters with a reinforcement learning algorithm. In our model, the system evolves to minimize both the collision rate and the access delay. The experimental results show that our scheme improves system performance in terms of the access success rate, the failure rate, the collision rate, and the access delay.
Results of a Qualitative Study to Develop a Patient Reported Outcome Measure for Patients with 4 Subtypes of Soft Tissue Sarcoma
Authors: Skalicky Anne M. , Ghate Sameer R. , Perez Jose Ricardo , Rentz Anne M.
Published: May 2017

Objective. The objective of this research was to develop a disease-specific symptom inventory for soft tissue sarcoma. Methods. Literature review and clinical expert and patient interviews were conducted to determine disease-specific symptoms important to patients with one of the four STS subtypes. Clinical experts identified the most relevant STS symptom items from the item pool developed from literature review. Concept elicitation interviews were conducted with patients to elicit their STS symptom experiences followed by a completion of the draft symptom list via web survey. A cognitive interview was conducted on the comprehension and importance of the symptom items. Results. Eighty-three symptom items were compiled and discussed with three clinical experts who identified 26 symptoms specific to the four STS subtypes. A total sample of 27 STS participants with self-reported leiomyosarcoma (74%), undifferentiated sarcoma (15%), synovial sarcoma (7%), or liposarcoma (4%) diagnosis completed the web survey and 10 were interviewed. The draft 12-item STS-specific symptom inventory includes abdominal pain, pressure in abdomen, early satiety, bloating, gastrointestinal pain, muscle pain, bone pain, heavy menstrual flow, shortness of breath, chest pain, cough, and painful menstruation. Conclusion. A number of symptoms are common across STS subtypes and may form a single STS symptom inventory.
Pyridostigmine Induced Prolonged Asystole in a Patient with Myasthenia Gravis Successfully Treated with Hyoscyamine
Authors: Khan Mohammad Saud , Tiwari Abhinav , Khan Zubair , Sharma Himani , Taleb Mohammad , Hammersley Jeffrey
Published: May 2017

Reversible acetylcholinesterase inhibitors are used as first-line treatment for myasthenia gravis. They improve symptoms by increasing concentration of acetylcholine at the neuromuscular junction and stimulating nicotinic receptors. Serious bradyarrhythmias can occur from muscarinic stimulation in heart, which in rare cases may progress to asystole. These patients can initially be managed with hyoscyamine, a muscarinic antagonist. Persistence of bradyarrhythmias even after hyoscyamine treatment may warrant pacemaker placement. We present a case of 65-year-old female patient who presented with diplopia, dysphagia, and muscle weakness who was diagnosed with myasthenia gravis. She developed significant sinoatrial node block with prolonged asystole after starting treatment with pyridostigmine which was successfully treated with hyoscyamine, thus avoiding pacemaker placement.
Asymmetric Expansion with a Modified Quad Helix for Treatment of Isolated Crossbite
Authors: Magnifico Marisabel , Di Blasio Alberto , Cassi Diana , Di Blasio Chiara , Gandolfini Mauro
Published: May 2017

Unilateral posterior crossbite often involves only one tooth, especially upper first molar; in these cases it is never easy to obtain an asymmetrical movement of a molar and a proper planning of the orthodontic device with its anchorage is necessary to avoid arch overexpansion. Thanks to its simplicity and efficacy, the modified Quad Helix here described represents a valid therapeutic tool in cases of isolated posterior crossbite.
High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant
Authors: Al-Otaibi Sarah S. , Alotaibi Faiza , Al Zaher Yaseer , Al Zaher Nabil , Dababo M. A.
Published: May 2017

Acinic cell carcinoma with high-grade transformation of the salivary gland is an unusual variant with less than fifty cases being reported in the literature. It is characterized by a low- and high-grade component juxtaposed with one another and tends to take on a more aggressive clinical course than its low-grade counterpart, suggesting a poor clinical outcome. We, hereby, report a case of acinic cell carcinoma in a 48-year-old woman with a 6-month history of a right parotid facial swelling rapidly increasing in size. The tumor was initially resected; however, residual focal tissue subsequently revealed areas typical of low-grade acinic cell carcinoma as well as high-grade transformation/dedifferentiation via histopathology.
Fabrication and Characterization of High-Sensitivity Underwater Acoustic Multimedia Communication Devices with Thick Composite PZT Films
Authors: Liu Jeng-Cheng , Cheng Yuang-Tung , Ho Sheng-Yun , Hung Hsien-Sen , Chang Shun-Hsyung
Published: May 2017

This paper presents a high-sensitivity hydrophone fabricated with a Microelectromechanical Systems (MEMS) process using epitaxial thin films grown on silicon wafers. The evaluated resonant frequency was calculated through finite-element analysis (FEA). The hydrophone was designed, fabricated, and characterized by different measurements performed in a water tank, by using a pulsed sound technique with a sensitivity of −190 dB ± 2 dB for frequencies in the range 50–500 Hz. These results indicate the high-performance miniaturized acoustic devices, which can impact a variety of technological applications.
An Efficient Secret Key Homomorphic Encryption Used in Image Processing Service
Authors: Yang Pan , Gui Xiaolin , An Jian , Tian Feng
Published: May 2017

Homomorphic encryption can protect user’s privacy when operating on user’s data in cloud computing. But it is not practical for wide using as the data and services types in cloud computing are diverse. Among these data types, digital image is an important personal data for users. There are also many image processing services in cloud computing. To protect user’s privacy in these services, this paper proposed a scheme using homomorphic encryption in image processing. Firstly, a secret key homomorphic encryption (IGHE) was constructed for encrypting image. IGHE can operate on encrypted floating numbers efficiently to adapt to the image processing service. Then, by translating the traditional image processing methods into the operations on encrypted pixels, the encrypted image can be processed homomorphically. That is, service can process the encrypted image directly, and the result after decryption is the same as processing the plain image. To illustrate our scheme, three common image processing instances were given in this paper. The experiments show that our scheme is secure, correct, and efficient enough to be used in practical image processing applications.
Effects of High Hydrostatic Pressure Processing on the Number of Bacteria and Texture of Beef Liver
Authors: Ogihara Hirokazu , Suzuki Hodaka , Michishita Masaki , Hatakeyama Hitoshi , Okada Yumiko
Published: May 2017

Providing beef liver for raw consumption was banned in Japan on July 1, 2012. To lift the ban, the establishment of effective countermeasures for safe raw consumption is necessary. In this study, we examined the effects of high hydrostatic pressure processing on raw beef liver. Beef liver samples subjected to 300 MPa of pressure or higher for 10 min at 25°C became firmer and showed a paler color and were considered unsuitable for raw consumption. More than 3.0 log reductions of bacteria were seen after treatments at 400 and 500 MPa, but the treatment with lower pressure did not show enough microcidal effects for safe consumption. Histological and ultrastructural analysis revealed that high hydrostatic pressure processing increased mitochondrial swelling and reduced rough endoplasmic reticula in hepatocytes, and such changes might be related to the observed changes of texture in the treated raw beef liver.
A Wide-Band Test Fixture for Analyzing Parasitic Effects of RF Passive SMD Components
Authors: Cao Xin , Tang Zongxi
Published: May 2017

A wide-band test fixture is designed for the measurement of parasitic effects of RF passive SMD (surface mounted devices) components. Two calibration methods, TRM (Thru-Reflect-Match) from 45 MHz to 2 GHz and TRL (Thru-Reflect-Line) from 2 GHz to 12 GHz, are used for error correction. The measurement standards and fixture are designed based on these two calibration methods. For experimental verification, the multilayered ceramic SMD capacitors of Johanson Technology are measured. The parasitic effects of the SMD capacitors are analyzed. The designed fixture is feasible and applicable for quick and accurate measurement of RF passive SMD components.
On the Interactions of Fused Pyrazole Derivative with Selected Amino Acids: DFT Calculations
Authors: Czaja Kornelia , Kujawski Jacek , Jodłowska-Siewert Elżbieta , Szulc Paulina , Ratajczak Tomasz , Krygier Dominika , Chmielewski Marcin K. , Bernard Marek K.
Published: May 2017

Due to the increasing prevalence of neoplasms, there is a permanent need for new selective cytostatic compounds. Anticancer drugs can act in different ways, affecting protein expression and synthesis, including disruption of signaling pathways within cells. Continuing our previous research aiming at elucidating the mechanism of pyrazole’s anticancer activity, we carried out in silico studies on the interactions of fused pyrazole derivative with alanine, lysine, glutamic acid, and methionine. The objective of the study is to improve our understanding of the possible interactions of pyrazole derivatives with the above-mentioned amino acids. For this purpose, we apply the DFT formalism (optimization using the B3LYP, CAM-B3LYP, PBE0, and M06L functionals) and interaction energy calculations (counterpoise corrected method based on the basis set superposition error, BSSE) together with QTAIM approach and estimation of the 1H NMR chemical shifts of analyzed pyrazole derivative using different basis sets and DFT functionals in CPCM solvation model (and water used as a solvent).
Comparison between a Machine-Learning-Based Method and a Water-Index-Based Method for Shoreline Mapping Using a High-Resolution Satellite Image Acquired in Hwado Island, South Korea
Authors: Choung Yun-Jae , Jo Myung-Hee
Published: May 2017

Shoreline-mapping tasks using remotely sensed image sources were carried out using the machine learning techniques or using water indices derived from image sources. This research compared two different methods for mapping accurate shorelines using the high-resolution satellite image acquired in Hwado Island, South Korea. The first shoreline was generated using a water-index-based method proposed in previous research, and the second shoreline was generated using a machine-learning-based method proposed in this research. The statistical results showed that both shorelines had high accuracies in the well-identified coastal zones while the second shoreline had better accuracy than the first shoreline in the coastal zones with irregular shapes and the shaded areas not identified by the water-index-based method. Both shorelines, however, had low accuracies in the coastal zones with the shaded areas not identified by both methods.
Application of ASTEC, MELCOR, and MAAP Computer Codes for Thermal Hydraulic Analysis of a PWR Containment Equipped with the PCFV and PAR Systems
Authors: Šadek Siniša , Grgić Davor , Šimić Zdenko
Published: May 2017

The integrity of the containment will be challenged during a severe accident due to pressurization caused by the accumulation of steam and other gases and possible ignition of hydrogen and carbon monoxide. Installation of a passive filtered venting system and passive autocatalytic recombiners allows control of the pressure, radioactive releases, and concentration of flammable gases. Thermal hydraulic analysis of the containment equipped with dedicated passive safety systems after a hypothetical station blackout event is performed for a two-loop pressurized water reactor NPP with three integral severe accident codes: ASTEC, MELCOR, and MAAP. MELCOR and MAAP are two major US codes for severe accident analyses, and the ASTEC code is the European code, joint property of Institut de Radioprotection et de Sûreté Nucléaire (IRSN, France) and Gesellschaft für Anlagen und Reaktorsicherheit (GRS, Germany). Codes’ overall characteristics, physics models, and the analysis results are compared herein. Despite considerable differences between the codes’ modelling features, the general trends of the NPP behaviour are found to be similar, although discrepancies related to simulation of the processes in the containment cavity are also observed and discussed in the paper.
Dexamethasone Modulates Nonvisual Opsins, Glucocorticoid Receptor, and Clock Genes inDanio rerioZEM-2S Cells
Authors: Sousa Jennifer Caroline , Magalhães-Marques Keila Karoline , da Silveira Cruz-Machado Sanseray , Moraes Maria Nathalia , Castrucci Ana Maria de Lauro
Published: May 2017

Here we report, for the first time, the differential cellular distribution of two melanopsins (Opn4m1 and Opn4m2) and the effects of GR agonist, dexamethasone, on the expression of these opsins and clock genes, in the photosensitiveD. rerioZEM-2S embryonic cells. Immunopositive labeling for Opn4m1 was detected in the cell membrane whereas Opn4m2 labeling shows nuclear localization, which did not change in response to light.opn4m1,opn4m2,gr,per1b,andcry1bpresented an oscillatory profile of expression in LD condition. In both DD and LD condition, dexamethasone (DEX) treatment shifted the peak expression ofper1bandcry1btranscripts to ZT16, which corresponds to the highestopn4m1expression. Interestingly, DEX promoted an increase ofper1bexpression when applied in LD condition but a decrease when the cells were kept under DD condition. Although DEX effects are divergent with different light conditions, the response resulted in clock synchronization in all cases. Taken together, these data demonstrate thatD. rerioZEM-2S cells possess a photosensitive system due to melanopsin expression which results in an oscillatory profile of clock genes in response to LD cycle. Moreover, we provide evidence that glucocorticoid acts as a circadian regulator ofD. rerioperipheral clocks.
An Investigation of Geography and Climate Induced Distresses Patterns on Airfield Pavements at US Air Force Installations
Authors: Sahagun Lauren K. , Karakouzian Moses , Paz Alexander , de la Fuente-Mella Hanns
Published: May 2017

This study investigated climate induced distresses patterns on airfield pavements at US Air Force installations. A literature review and surveys of Pavement Condition Index indicated that the predominant factor contributing to the development of pavement distress was climate. Results suggested that, within each type of pavement distress, a geographic pattern exists which is strongly correlated to conventional US climate zones. The US Air Force Roll‐Up Database, housing over 50,000 records of pavement distress data, was distilled using a process designed to combine similar distresses while accounting for age and size of samples. The process reduced the data to a format that could be used to perform krig analysis and to develop pavement behavior models for runways built with asphalt cement (AC) and Portland cement concrete (PCC). Regression and krig analyses were conducted for each distress type to understand distress behavior among climate zones. Combined regression and krig analyses provided insight into the overall pavement behavior for AC and PCC runways and illustrated which climate zone was more susceptible to specific pavement distresses. Distress behavior tends to be more severe in the eastern US for AC and in the western US for PCC runway pavements, respectively.
Personality Traits as Predictor of Emotional Intelligence among the University Teachers as Advisors
Authors: Alghamdi Nawal G. , Aslam Muhammad , Khan Khushnoor
Published: May 2017

The focus of the present study was to investigate personality traits as the predictor of emotional intelligence (EI) among the university teachers working as student advisors. A sample of the study comprised 100 student advisors (male = 50; female = 50). The age range of the sample was 21–40 years. Schutte Emotional Intelligence Scale (SEIS) and Big Five Inventory (BFI) were used to measure emotional intelligence (EI) and personality traits. For the statistical analysis of the data, T‐test and regression analysis were computed. The findings revealed that three personality traits, extraversion, agreeableness, and openness to experience, emerged as significant predictors of EI. The findings also revealed that conscientiousness and neuroticism have no impact on EI. T‐tests indicated that there are no gender differences in EI. Considering the implication of personality traits on EI among university teachers/student advisors, the current research may assist in augmenting the organizational behavior in general and boost the productivity in particular which are both essential ingredients for the deliverance of services to all the stakeholders linked with the educational system in Saudi Arabia.