bluuebunny/crossref_metadata_2025 huggingface dataset:
Dugem di Kalangan Pelajar SMA Swasta di Kota Surabaya
Authors: Rudiantari Jessica Ozymandias
Published: July 2022

Surabaya sebagai kota terbesar kedua setelah Jakarta memiliki banyak tempat hiburan malam seperti tempat karaoke, tempat kongkow, bar dan diskotik. Diantara pelajar SMA yang memiliki aktivitas malam hari di diskotik adalah pelajar SMA swasta. Fenomena menarik peneliti untuk meneliti dugem pelajar SMA swasta di Kota Surabaya.

Metode peneliti ini adalah metode etnografi lokasi penelitian di salah satu diskotik besar di Surabaya yaitu diskotik A. Penelitian ini dilakukan dengan observasi di diskotik besar yang ada di Kota Surabaya, peneliti melakukan  wawancara mendalam kepada 5 informan pelajar SMA swasta. Lalu, observasi aktivitas pelajar SMA swasta di diskotik A, mentranskrip,mengkatagorikan mendeskripsikan hasil penelitian dan menganalisis menggunakan teori.

Hasil dari penelitian ini menunjukkan pelajar SMA di kalangan swasta melakukan aktivitas dugem ke diskotik sebagai kegiatan mengisi waktu luang untuk bersenang- senang karena informan putus cinta, kesepian, bosan, kurangnya perhatian orang tua dan gaya hidup.  Peneliti mendeskripsikan variasi perilaku dugem pelajar SMA swasta di lokasi dugem yaitu merokok, mengkonsumsi minuman beralkohol, mabuk, berjoget, menggoda, mencari pasangan, ciuman berkelahi dan sering mengunjungi diskotik. Dugem pelajar SMA swasta di Kota Surabaya juga berakibat uang saku habis, terlambat masuk sekolah dan prestasi menurun.
Analysis of Trend in Research Papers Related to Early Logical Thinking Education in Early Childhood Education
Authors:   The Association of Korea Counseling Psychology Education Welfare, PARK Kee-Hong , RIM Sang-Do
Published: July 2022

In this study, 52 research papers related to logical thinking education in early childhood education published in domestic academic journals from 1988 to December 2021 were studied on a 10-year basis, general research trends (by age, research area), research methods, and research results. Trends (by research type, by research subject, by data collection method, by data analysis method, by research result) were analyzed. Following the second round of data collection, preliminary research, this study, and data analysis were carried out in the order. Research Results First, research related to logical thinking education in early childhood education increased rapidly in the 3rd period (2000-2009), and critical thinking was relatively the most studied in the field. Second, experimental studies of quantitative research and studies targeting infants were also relatively frequent, and test methods and difference verification methods were used a lot for data collection and data analysis. And the research result was found to be focused on improving the logical thinking of early childhood teachers and preschool teachers. The significance of this study is that it comprehensively analyzed the current status and actual conditions of research related to logical thinking education in early childhood education and suggested a direction to diversify the research area.
Data-based interpretation of emerging contaminants occurrence in rivers using a simple advection-reaction model
Authors: Ginebreda Antonio , Barceló Damià
Published: July 2022

Our knowledge of the river’s qualitative status generally relies on discrete spatial and temporal observations organized under what is commonly known as a “monitoring network”. Network performance is constrained by its spatial - temporal resolution, which is severely limited by the costs associated with the whole sampling and analytical process. Alternatively, modeling allows predicting the spatial - temporal variable profile at any resolution at affordable computing costs. However, it involves high uncertainty in the parameterization and requires experimental validation as well. Here, we aimed at reconciling monitoring and modeling, deriving simple steady-state advection-reaction (reactive-transport) models from monitoring data. They are based on graph-theoretical concepts, notably the use of the Laplacian matrix, which captures the river network topology, the interaction between adjacent sites, and the advection process between them. The local reactive process is described by a first-order decay reaction. The application of these models provided relevant information about the variables monitored, such as the local dynamics, the distance of the site’s influence, the degree of synchronization, or the external input/output to the system, which is useful for both scientific and management purposes. The model was tested in the Llobregat River (NE Spain) basin, with 70 emerging contaminants of different classes (pharmaceuticals, pesticides, perfluorinated substances, endocrine disruptors, and drugs of abuse). The monitoring network included 14 sites (7 in the mainstream, 4 in the Cardener, and 3 in the Anoia tributaries) and was monitored in 2 campaigns. These models can help water managers to optimize the design of river monitoring networks, a key aspect of environmental regulations.
Correlation Survey of Workplace Stress, Sleep, and Resilience of Nursing Preceptor in Teaching Hospital
Authors: Ji Ruo-Yu , Su Chen-Yun , Lin Shin-Jean , Li Jung-Fen , Ming Jin-Lain , Chiu Hsiao-Hui
Published: July 2022

Background: Nursing preceptor are under the pressure of clinical and teaching work. The impact of pressure on physical and mental health includes depression, anxiety, sleep disorders, and even mental exhaustion and exhaustion. If they fail to get relief from work, it will cause negative emotions, and will be physically and mentally exhausted for a long time.Aims: To understand the workplace stress, sleep, and resilience of nursing preceptor.Methods: The study used a cross-sectional study design. The enrollment setting was the Nursing Department of a teaching hospital. A total of 35 nursing preceptors.Results: A total of 54.29% of situational anxiety were moderate, 80.0% of trait anxiety was moderate, 57.1% had difficulty falling asleep, 65.7% were unable to maintain a long sleep, and 71.4% had trouble waking up too early, and 91.4% expressed dissatisfaction with sleep. 80.0% have sleep disturbance, and the resilience is low (below 121 points), accounting for 42.8%. Resilience and situational anxiety (p=.003), trait anxiety (p=.001), sleep disturbance (p<.001), physiological stimulation of sleep physical and mental state (p=.003), and cognitive stimulation of sleep physical and mental state (p< .001) are all negative correlations. Trait anxiety is positively correlated with sleep disorders (p<.001).Conclusion: The score of resilience is low, and the various distress states are higher; the higher the distress states, the higher the sleep disturbance. Therefore, for the stress and sleep problems of clinical nursing instructors, caring services should be provided in the future, or through group activities that provide resilience enhance face stress, and reduce sleep disturbance.Recommendations: Clinics can routinely arrange resilience groups to help nurses increase their ability to face stress and improve their quality of life.
Forming of social order for teachers in the history of education in Russia
Authors: Danilova L. N.
Published: July 2022

Introduction. The first state educational institution for teacher’s training was the teachers’ seminary established in 1783. However, the teaching profession appeared in Russia long before that and was supported by social request. This fact builds questions about transformations of public expectations in relation to teachers, i.e. about the history of the social order to teachers. That order had not been realized and reflected in some documents for a long time, but its influence on education in Russia can be clearly observed already in the 17th century.

Purpose setting. The article attempts to determine features of its becoming.

Methodology of the study. The research is based on a large layer of literature, on the principles of dialectics and historicism, and uses comparative historical analysis, deduction, culturomics, content analysis, statistics and other theoretical methods.

Results. Features of forming of a social order to teachers in the 17th and 18th centuries are identified and specified. The factors and conditions of its forming in the specified historical period are characterized; its structural components were determined, also patterns of changes in the social order for teachers and its actualization time were detected.

Conclusion. In the 17th century, there was an order for teachers in the Russian Tsardom, the subject of which was the church, but partly also the state and townspeople. The state imposed requirements on teacher’s work, regulating some aspects of school organizing. The emerging in those times trend of transition from religious characteristics of the teacher to professional ones finally took shape at the beginning of the 18th century, when the state order for teachers had been formed. By the middle of the century, the image of the teacher had radically changed, and there were requirements of professionalism in the being taught science and of positive personal characteristics, which found its place in organizing of the first teachers’ seminary: the order for teacher’s methodological training began thanks to it. Patterns of formation of a social order to teachers (society always has high expectations from either professional or personal characteristics of the teacher; during periods of social conflicts and changes the requirements for his personal characteristics are actualized; that transfer depends on social stability) confirm that clearly it depends on historical periods and socio-political conditions.
The use of modular-rating technology of teaching mathematics to students of Altai State Agricultural University
Authors: Koksharova M. V. , Morozova S. V. , Belchikova O. G.
Published: July 2022

Introduction. New requirements are put forward for the organization of educational process, and improving the quality of training of graduates.

Purpose setting. Therefore, teachers are faced with the need to apply modular-rating training technology which instantly reacts to changes in the situation in the labor market and can adjust the specialist model. It is democratic in its principles, content, and organization of the educational process. Modular-rating technology provides individualization of educational programs and the ways of their assimilation depending on the abilities and interests of students.

Methodology of the study. The authors carried out modular structuring of the “Mathematics” course; methodological support (tests, individual tasks, etc.) of the modular-rating program was developed. A special role in the technology of modular-rating education is assigned to control over the knowledge of students, the authors used current, midterm and fi control. The quality of knowledge and skills of students in mastering the module was determined by various control methods: oral and written survey, control work, individual task, calculate and graphic work, etc. In addition, a testing method was used. To assess the effectiveness of student educational activities, a rating is used which is determined by points set in a selected unifi scale with a clear gradation of the level of theoretical knowledge, practical skills and abilities. The rating is formed during the entire period of the student training.

Results. In modern conditions, higher education is faced with the tasks of forming a specialist with stable incentives for further professional self-improvement, activation and development of student cognitive abilities, differentiation of training content and individualization of pedagogical infl in accordance with the level of student training.

Conclusion. The authors conclude that one of the effective ways to solve these problems is to train students according to the modular-rating system.
Knowledge about persons with disabilities as an important factor in promoting of tolerance (on the example of students from universities in Kirov)
Authors: Kazakova O. A. , Stasyuk E. V.
Published: July 2022

Introduction.The humane structure of society involves the equality of all people, notwithstanding the characteristics of their individual development, and the tolerant attitude to them.

Purpose setting.The purpose of the research is to identify the level of knowledge about people with special health opportunities among senior students of different nationalities who study in higher educational institutions in the city of Kirov and to work out on this basis recommendations for educating young people to be tolerant towards people with disabilities.

Methodology of the study.To achieve the research goal at the fi stage, the authors have studied psychological, pedagogical and sociological literature on this problem. At the second stage, the authors have conducted the study through anonymous questionnaire survey of senior students of Vyatka State Agrotechological University and Kirov State Medical University in order to study their views about people with disabilities.

Results.Based on the analysis and statistical processing of data, the knowledge and ideas about people of this category, their problems, individual features, the role of the media and the state in the coverage of these problems, the legislative protection of the rights of disabled people have been revealed.

Conclusion.As a result of the study, the authors have noted the differences and similarities in the knowledge of students of different universities in Kirov about people with disabilities, and have highlighted the importance of creating new conditions in universities for forming the tolerant attitude towards people with different physical and mental abilities; specifi pedagogical and educational measures have been proposed.
Socio-methodological aspects of the development of the flagship university
Authors: Knyazev N. A. , Buyankina R. G. , Rakhinsky D. V.
Published: July 2022

Introduction. The article examines the specificity of the flagship university – a new component in the regional development of structures related to higher education, economics and management.

Purpose setting. The objective of the study is to analyze the list of scientific and pedagogical competencies, which (due to its novelty) it has not yet been fully formed by scientists in the form of a clear system of knowledge. The identification of this so-called unstructured list of scientific and pedagogical competencies is necessary to improve the system style in the implementation of educational and pedagogical activities of the specialists of the flagship university.

Methodology of the study. The methodology of the analysis of the material included in the article is based on the principle of interaction of intersectoral and interdisciplinary types of scientific and technological activities.

Results. The article reveals the content of the innovation policy of state, at the regional level of which the solution of complex socio-economic problems is inextricably linked with the activities of the flagship university. The flagship university is new educational component in the system of interaction between government, science and entrepreneurship. The comparative analysis of research approaches has revealed an unstructured list of competencies of a scientific and pedagogical employee of the university necessary for the implementation of educational activities. Since educational activities are aimed at the formation of certain professional competencies and values among students, the priority personal qualities and socio-professional competencies of university teachers are highly specialized skills and general erudition, methodological thinking, continuous professional development, motivation for pedagogical work, communicative abilities. Pedagogical activity at universities is associated with the participation of a teacher in research work. The novelty of our research consists in structuring the list of personal qualities and socio-professional competencies of a modern teacher and student that are in demand in relevant fields of activity/

Conclusion. Based on the results achieved in the process of analyzing publication materials, the paper summarizes the innovative ability of the flagship university to implement specifi management projects, improve personal competencies, make informed decisions when selecting specialists and personnel changes. The results of the study can be used by university teachers in the framework of building subjective perspectives of professional and personal development.
Social capital as a factor in the development of civic engagement of students
Authors: Zharova M. V.
Published: July 2022

Introduction. In modern conditions of becoming of a civil society and the constitutional state the public attention is concentrated on modern youth whose civic activity affects how the tasks set for society and the state will be implemented.

Purpose setting. The future of Russia is largely determined by the values that are emerging today in the communities of schoolchildren and students. In this regard, the objective of forming conceptual representations about the processes of formation of civic engagement of young people becomes to be relevant. The purpose of this study is to analyze the social capital of the individual as a factor influencing the civic activity of young people studying both at school and at university, including those who are representatives of the Russian movement of schoolchildren. Methodology and methods of the study. The paper provides a theoretical systematic and meaningful analysis of such variables that form social capital as the value attitudes of young people, the level of trust in various agents of influence and the strength of communication with them.

Results. The conducted correlation analysis confirmed the hypothesis that exists a relationship between these variables and the object of study. It is shown that modern youth is largely focused on solving their own problems, focused on the "inner circle", is not inclined to trust people in general, lacks solidarity values, concentrating on individualistic interests, and this significantly hinders their inclusion in the manifestation of civic activity. The exception is the representatives of the Russian movement of schoolchildren, who have a high level of trust in the state, patriotic ideals and willingness to interact with public organizations, they are prone to civic responsibility and social activity.

Conclusion. It is necessary to create mechanisms for the inclusion of young people in various communities to solve socially significant issues, to strengthen the values of solidarity, as well as to form a unified value system in the youth environment, in which not only universal values, but also patriotism would occupy a significant place.
Film Properties Using Metal Salts Washing for Perovskite Solar Cells
Authors: Thomas Ankit Stephen
Published: July 2022

Perovskite Solar Cell (PSC) is a third-generation photovoltaic device known for its rapid improvement in efficiency levels over the past decade. Moreover, the added benefits of abundant sourcing of raw materials, uncomplicated fabrication process, organic and inorganic device materials, and tuneable bandgaps make this technology a sustainable energy alternative. However, the efficiency values of these devices are subjected to variation depending on factors such as material compatibility, environmental conditions, energy band alignment of device components and stability characteristics to extrinsic and intrinsic factors. One such vital intrinsic factor is film morphology, homogenous and superior film quality formation and pinhole and trap-free films. In this study, we have investigated the formation of perovskite films on a qualitative basis using metal chloride washing of salts such as Erbium, Antimony, Cadmium and Chromium Chloride. The study aims to analyse the difference in film formation with various metal chloride washing and how this could potentially impact or contribute to photovoltaic performance if the devices are fabricated.
Investigation of the Optimal Prime Boost Spacing Regimen for A Cancer Therapeutic Vaccine Targeting Human Papillomavirus
Authors: Da Silva Diane M. , Martinez Emma A. , Bogaert Lies , Kast W. Martin
Published: July 2022

Therapeutic vaccine studies should be designed to elicit durable, high magnitude, and efficacious T cell responses, all of which can be impacted by the choice of vaccination schedule. Here, we compare different prime-boost intervals (PBI) in a human papillomavirus (HPV) model using HPV16E6E7 Venezuelan equine encephalitis virus replicon particle (VRP) vaccination to address the optimal boosting schedule, quality of immune response, and overall in vivo efficacy. Six different vaccine regimens were tested with each group receiving booster vaccinations at different time intervals. Analysis of T-cell responses demonstrated a significant HPV16 E7 specific CD8+T cell response with minimally a one-week PBI between antigen re-exposure. Significant E7-specific in vivo cytotoxicity was also observed with longer PBIs. Additionally, longer PBIs led to an enhanced memory recall response to tumor challenge, which correlated with differential expansion of T cell memory subsets. Our findings imply that when using alphavirus vector platforms as a vaccination strategy, a one-week PBI is sufficient to induce high magnitude effector T cells with potent anti-tumor activity. However, longer PBIs lead to enhanced long-term protective anti-tumor immunity. These findings have implications for therapeutic vaccine clinical trials in which shorter intervals of prime-boost regimens may lead to suboptimal durable immune responses.
The impact of measures aimed at improving the welfare of the Russian population on macroeconomic dynamics
Authors: Antipov Valeriy Ivanovich , Malinetskii Georgii Gennadyevich , Mitin Nikolay Alexeevich
Published: July 2022

“Saving the people” implying in particular the growth of incomes of the majority of the population of Russia is currently one of the priorities of its development. In addition, an important problem at present is the expansion of the country’s domestic market. A group of researchers presented to the State Duma a set of measures related to changes in tax policy and aimed at improving the welfare of the people of Russia. We analyze the macroeconomic implications of the proposed range of measures on the basis of an expert simulation dynamic model. We show that the proposed reforms will significantly accelerate the economic development of Russia.
The Analysis of the Roles of Bitcoin, Ethereum, and Gold as Hedge and Safe-Haven Assets on the Indonesian Stock Market before and during the COVID-19 Pandemic
Authors:   University of Indonesia, Indonesia, Wijaya Carla A. , Ulpah Maria ,   University of Indonesia, Indonesia
Published: July 2022

The uncertainty due to the COVID-19 outbreak has encouraged investors to look for value hedging instruments to minimize risk, which can be in the form of hedging assets or safe-haven assets. In response to it, this study aims to find out whether Bitcoin, Ethereum, and gold can behave as hedging and safe-haven assets before and amid the pandemic in Indonesia. The strategy is by observing the effects of volatility and return of Bitcoin, Ethereum, and gold on the Indonesian stock market. This study employed both quantile regression and simple linear regression models on data of daily closing price taken before and during COVID-19. This study finds that they can be hedge and safe-haven assets during the COVID-19 pandemic in Indonesia. The findings show some significant correlations between assets that can help investors determine which assets can be hedging instruments.
Antigenic Components of Chemical Bivalent Cholera Vaccine, Methods of their Isolation and Control
Authors: Vorob’eva S. A. , Durakova O. S. , Gromova O. V. , Volokh O. A. , Klokova O. D. , Nikiforov A. K.
Published: July 2022

The paper presents a review of the data on the methods of isolation and control of Vibrio cholerae antigens – cholerogen-anatoxin and O-antigens of Inaba and Ogawa – components of the oral bivalent chemical cholera vaccine produced by the RusRAPI “Microbe”, the only prophylactic drug against cholera registered in the territory of the Russian Federation. Currently, the vaccine is produced using the method of segregated manufacturing of cholerogenanatoxin and O-antigens Inaba and Ogawa with step-by-step control of their main properties, which ensures the production of a high-quality finished product. Ultrafiltration is an effective method for concentrating a semi-finished product, which helps to reduce losses and increases the yield of the final product. It remains promising to develop a method for gentle steril ization of O-antigens to maximize the preservation of specific activity. To control the specific activity of the antigenic components and the finished vaccine preparation, a complex of in vivo and in vitro methods is applied. However, the multi-stage process and duration, the use of several types of laboratory animals, as well as modern WHO requirements determine the need for the introduction of alternative in vitro control methods. The use of cell cultures as a replacement for the biological method appears prospective, and demonstrates a positive correlation with animal tests. To assess the activity of antigens, the use of an immunochemical method – dot-immunoassay with gold nanoparticles – is put forward, which will make it possible to harmonize the control method at all stages of the production process, as well as to determine the serovar specificity of Vibrio cholerae O-antigens. The development of molecular-genetic, microbiological, immunochemical methods is relevant for a more complete and comprehensive control of the main immunogens of industrial strains of cholera vibrio. The introduction of promising methods for obtaining antigens and monitoring their properties will allow for a more complete characterization of the component composition of the finished dosage form of the chemical cholera vaccine.
Overview of Hantavirus Infections in the World, the Epidemiological Situation on Hemorrhagic Fever with Renal Syndrome in the Russian Federation in 2021, and Forecast for 2022
Authors: Savitskaya T. A. , Ivanova A. V. , Chumachkova E. A. , Pospelov M. V. , Isaeva G. Sh. , Reshetnikova I. D. , Kabve E. , Davidyuk Yu. N. , Trifonov V. A. , Ziatdinov V. B. , Serova I. V.
Published: July 2022

The paper presents a description of the epidemiological situation on Hantavirus infection incidence in the countries around the world. Comparative analysis of the intensity and dynamics of the epidemiological process of hemorrhagic fever with renal syndrome (HFRS) in the Russian Federation by Federal Districts in 2021 has been carried out and forecast of the HFRS incidence for 2022 prepared. The study has revealed that tense situation on incidence of hantavirus diseases was observed in the world in 2021. On the territory of the Russian Federation, there was a decrease in the HFRS incidence in 2021 (by 1.7 times compared to 2020). However, the results of epidemiological analysis of the HFRS incidence, epizootiological data and laboratory studies in certain Federal Districts of the Russian Federation indicate that the epidemiological situation on HFRS remains tense. High risk of HFRS infection is predicted in a number of regions of the country due to the favorable natural and climatic conditions in the winter period of 2021–2022 with a heavy snow cover, which contributed to the under-snow reproduction of small mammals, the main carriers of HFRS. The presence of infected rodents testifies to a high likelihood of complication of the epidemiological situation in areas of increased epidemic risk of HFRS.
Knee Arthrodesis for Mycobacterium avium Complex Native-Knee Septic Arthritis in a Patient with Dermatomyositis
Authors: Jabbouri Sahir , Halperin Scott J. , Pathak Neil , Wilhelm Christopher V. , Ng Mitchell , Arsoy Diren
Published: July 2022

Case:

A 43-year-old woman with dermatomyositis presented with Mycobacterium avium complex (MAC) knee septic arthritis with superimposed polymicrobial infection. After poor infection control with antibiotic therapy, she underwent debridement and antibiotic cement spacer placement, followed by knee arthrodesis 6 months later. At 2-year follow-up, she had no pain and was ambulating without assistive devices.

Conclusion:

As far as we know, this is the first reported case of MAC native-knee septic arthritis successfully treated with antibiotic cement spacer followed by knee arthrodesis. This case sheds insight on treatment strategies for a rare native-knee infection.
Successful Emergent Treatment of Limb-Threatening Amniotic Constriction Band in a Neonate with a 2-year Follow-up
Authors: Veitenheimer Travis G. , Johnson Eric B. , Chenoweth Brian A.
Published: July 2022

Case:

A 29-week-old gestational age neonate born by emergent cesarean delivery was found to have a circumferential upper arm amniotic constriction band. Initial removal of the amniotic band at the time of delivery uncovered a circumferential skin band with profound venous obstruction but preserved Doppler arterial flow. Emergent excision of the constricted skin band with fasciotomies of the arm and forearm was performed shortly after birth to preserve the extremity.

Conclusion:

This report outlines a visualized constriction band at the time of delivery causing neurovascular compromise to an extremity of a neonate. Prompt intervention ensued preserving both form and function with an excellent 2-year follow-up.
Planeamiento financiero y la rentabilidad de la empresa Quimica Hispana S.A., Lima - 2021
Authors:   , Cavides Ramirez Evelyn Eliana
Published: July 2022

Se desarrollo el presente estudio con el propósito de determinar la relación que existe entre planeamiento financiero y rentabilidad de la empresa Química Hispana S.A. , Lima-2021 ; la empresa mencionada es reconocida por la organización empresarial que presenta a diario y la toma de decisiones que impulsan su desarrollo de manera favorable y significativa. La metodología utilizada es básica, de diseño no experimental, enfoque cuantitativo y transversal; con base en el análisis de datos de la información recolectada a través del instrumento (cuestionario) que fue aplicado a los colaboradores de la empresa. Los resultados analizados con el software SPSS VS 26 demuestran que existe relación entre las variables: planeamiento financiero y rentabilidad. En cuanto a las dimensiones de planeamiento financiero presentadas en el desarrollo de la investigación , se demostró que tienen relación significativa con rentabilidad. Es decir el planeamiento financiero actúa como un mecanismo de apoyo que permite a la empresa mantenerse en crecimiento, trazar sus objetivos y tomar decisiones adecuadas en el presente y futuro . Por otro lado, conocer la rentabilidad de un negocio es esencial para conocer las ganancias y la viabilidad de este, de esta manera se puede optar por estrategias como la inversión.
Jiedu Tongluo decoction attenuates myocardial fibrosis through inhibition of the TGF-β1/Smad2/3 pathway
Authors: Hui Ju , Li Le , Zhang Huan , Wang Bin , Shi Jiaxin , Song Jing , Guo Jiajuan , Li Xiangjun
Published: July 2022

Jiedu Tongluo (JDTL) Decoction is a traditional Chinese medicine formula containing three herbal ingredients, and widely used for treating myocardial fibrosis (MF). This study aimed to investigate the molecular mechanism of the effect of JDTL Decoction on myocardial fibrosis.In this study, 6 compounds of JDTL Decoction were identified by HPLC. HE and Masson staining showed that in the isoproterenol hydrochloride-induced MF rat model, JDTL treatment can protect the myocardial structure and inhibit the expression of collagen III. The results of immunohistochemistry also showed that JDTL treatment can significantly reduce vimentin and α-SMA expression, as well as TGF-β1 expression and phosphorylation of Smad2/3 in the rat MF model. RCF, a rat cardiac fibroblast cell line was used as a tool for in vitro study. Using the methods of hydroxyproline detection, MTT, wound healing test, western blot, and double immunofluorescence staining, our in vitro study confirmed the inhibitory effects of JDTL Decoction on proliferation, migration, and trans-difference ability of RCF cells, as well as the molecular mechanisms underlying the inhibitory effects of JDTL Decoction, including the inhibition of TGF-β1/Smad2/3 pathway through down-regulation of TGF-β1 expression and phosphorylation of Smad2/3 as well as the inhibition of the expression of vimentin and α-SMA. In conclusion, JDTL Decoction can prolong the process of myocardial fibrosis through the inhibition of the TGFβ1/Smad2/3 signaling pathway.
Esketamine combined with pregabalin on acute postoperative pain in patients undergoing resection of spinal neoplasms: study protocol for a randomized controlled trial
Authors: Sun Wanchen , Wang Juan , Wang Jing , Fan Jingyi , Zhou Yang , Wang Yunzhen , Han Ruquan
Published: July 2022

Background
Perioperative pain management is one of the most challenging issues for patients with spinal neoplasms. Inadequate postoperative analgesia usually leads to severe postsurgical pain, which could cause patients to suffer from many other related complications. Meanwhile, there is no appropriate analgesic strategy for patients with spinal neoplasms.
Methods/design:
This is a protocol for a randomized double-blind controlled trial to evaluate the effect of esketamine combined with pregabalin on postsurgical pain in spinal surgery. Patients aged 18 to 65 years scheduled for spinal neoplasm resection will be randomly allocated into the combined and control groups in a 1:1 ratio. In the combined group, esketamine will be given during the 48-h postoperative period, and pregabalin will be taken from 2 hours before the surgery to 2 weeks postoperatively. The control group will receive normal saline and placebo capsules at the same time points. To ensure the accuracy and reliability of this trial, all the researchers and patients will be blinded until the completion of this study. The primary outcome will be the proportion of patients with acute moderate-to-severe postsurgical pain (Visual Analogue Scale, VAS ≥ 40) during the 48-hr postoperative period. The secondary outcomes will include the maximal VAS scores during the 2-h, 1-d, 2-d, 3-d postoperative periods and discharge, the incidence of acute postsurgical pain at each other time point, chronic postsurgical pain assessment, neuropathic pain assessment, and the incidence of drug-related adverse events and other postoperative complications, such as postoperative delirium and postoperative nausea and vomiting(PONV).
Discussion
The aim of this study is to evaluate the effect of esketamine combined with pregabalin on acute postsurgical pain in patients undergoing resection of spinal neoplasms. The safety of this perioperative pain management strategy will also be examined.
Trial registration:
ClinicalTrials.gov, NCT05096468. Registered on October 26, 2021.
A new look at the anthropogenic global warming consensus: an econometric forecast based on the Arima Model of paleoclimate series.
Authors: Santos Gilmar Veriato Fluzer , Cordeiro Lucas Gamalel , Rojo Claudio Antonio , Leismann Edison Luiz
Published: July 2022

This paper aims to project a climate change scenario using a stochastic paleotemperature time series model and compare it with the prevailing consensus. The ARIMA - Autoregressive Integrated Moving Average Process model was used for this purpose. The results show that the parameter estimates of the model were below what is established by the anthropogenic current and governmental organs, such as the IPCC (UN), considering a 100-year scenario, which suggests a period of temperature reduction and a probable cooling. Thus, we hope with this study to contribute to the discussion by adding a statistical element of paleoclimate in counterpoint to the current scientific consensus and place the debate in a long-term historical dimension, in line with other existing research on the topic.
Development and psychometric evaluation of the High-Risk Pregnancy Well-being Index
Authors: Mirzakhani Kobra , Khadivzadeh Talat , Faridhosseini Farhad , Ebadi Abbas
Published: July 2022

Introduction: Assessment of well-being in high-risk pregnancy (HRP) is the key to achieve positive maternal and fetal outcomes. Although there are a wide range of instruments for well-being assessment, none of them is comprehensive for well-being assessment in HRP. The present study aimed at the development and psychometric evaluation of the High-Risk Pregnancy Well-Being Index (HRPWBI). Methods: This methodological study was conducted using the Waltz’s four-step method. The dimensions of well-being in HRP were determined based on a conceptual model and the blueprint and the item pool of HRPWBI were developed. Then, the face and the content validity were assessed and item analysis was performed. Construct validity was also assessed through exploratory factor analysis with principal component analysis on the data obtained from 376 women with HRP. Finally, internal consistency, test-retest stability, sensitivity, and interpretability of HRPWBI were assessed. Findings: The content validity index of HRPWBI was 0.91. In factor analysis, 33 items were loaded on seven factors which explained 53.771% of the total variance. Internal consistency, relative stability, absolute stability, sensitivity, and interpretability of HRPWBI were confirmed with a Cronbach’s alpha of 0.837, a test-retest intraclass correlation coefficient of 0.974, a standard error of measurement of 0.92, a minimal detectable change of 8.09, and a minimal important change of 2.92, respectively. Conclusion: HRPWBI is a valid and reliable instrument for well-being assessment among women with HRP. It can be used to assess well-being and the effects of well-being improvement interventions on well-being among women with HRP.
Data-constrained analytical model for the propagation of a penny-shaped hydraulic fracture under true triaxial stresses
Authors: Feng Runhua , Sarout Joel , Dautriat Jeremie , Zhang Jiecheng , Roshan Hamid , Rezaee Reza , sarmadivaleh mohammad
Published: July 2022

Hydraulic fracturing is a coupled multi-physics and scale-dependent process requiring an extensive numerical-laboratory appraisal to assess feasibility in the field. Developing a robust model of hydraulic fracture propagation requires knowledge of the time evolution of the fracture’s geometrical attributes, e.g., width/aperture and length/radius. However, it is inherently challenging to directly measure even the simplest fracture attribute (i.e., radius) within a rock sample subjected to in-situ stresses in the laboratory, let alone in the field. In this study, an analytical model is developed to predict the time evolution of the radius for a penny-shaped hydraulic fracture. This model (Rd) predicts the fracture opening and internal pressure gradient using Poiseuille’s law and assuming a self-similar propagation. Scaling laws and dimensional analysis are used to define propagation regimes; and non-linear hydro-mechanical coupling is accounted for in the near-tip region. We also quantify the growth of the fracture radius using linear elastic fracture growth model (RE); and tip asymptotic solutions (RV and RT). A comparison of the three analytical models with published experimental data reveal that (i) the asymptotic solutions are limited to linearly elastic and homogeneous materials, i.e., PMMA; (ii) the performance of the linear elastic model (RE) poorly matches the experimental data, especially for unstable propagation situations; (iii) the new Rd model takes advantage of a robust reconstruction of the temporal radius growth of hydraulic fracture problems under realistic stress conditions, and including multiscale propagation regimes, cohesive effects, as well as stable and unstable propagation regimes of geomaterials.
Rapid morphological shifts in a co-invaded assemblage of lizards
Authors: Phillips John G. , Hagey Travis J. , Hagemann Molly , Gering Eben
Published: July 2022

Phenotypic change plays diverse and crucial roles in biotic invasion, but most studies of invasions focus on individual species. To compare ecomorphological changes among co-invading species with overlapping native niches, we examined three lizards on the island of O‘ahu: (Anolis carolinensis, A. sagrei, Phelsuma laticauda). Using specimens from three decades of unfolding invasions obtained from museum collections and the field, we quantified temporal shifts in three ecologically relevant traits: snout vent length (SVL), forelimb-, and hindlimb-length (limb lengths relative to SVL). We found unique patterns of phenotypic change in each species as well as sex-specific changes within species: 1) both anole species increased in SVL since the 1980s, 2) forelimb length increased in Phelsuma females and in both sexes in A. carolinensis, and 3) relative hindlimb length increased in Phelsuma (both sexes) and decreased in A. sagrei (both sexes). The observed changes involve ecomorphological traits that are feasibly consequential to invasion dynamics. Our study illustrates how museum- and field-based research can be integrated to document nuanced temporal patterns in the phenotypes of co-invading species that share similar niches in their native ranges; it also raises important questions about the underlying process(es) driving species- and sex-specific change in co-invaded systems.
Optical Soliton Solutions of the Conformable Time Fractional Radhakrishnan–Kundu–Lakshmanan Model
Authors: YADAV VIKASH , Gupta Rajesh Kumar
Published: July 2022

In the present study, we have obtained different kinds of wave solutions which possess distinctive physical characteristics of the nonlinear conformable time fractional Radhakrishnan–Kundu–Lakshmanan model by utilizing the generalized Jacobi elliptic function (GJEF) method. 3-D surfaces to some of the reported solutions are plotted and the dependence of the behaviour of the solutions on the fractional derivative has also been analyzed in the present study. In addition to providing physical explanations of Radhakrishnan-Kundu-Lakshmanan equation, the solutions presented here may also provide an insight into the the study of wave propagation in various conformable fractional nonlinear models arising in nonlinear sciences.PACS 42.65.Tg . 02.90.+p . 02.30.JrMSC 2020 35B30 . 35C08 . 26A33
Cavernous hemangioma of the knee, causing pain following a fall in a 5-year-old girl: A case report.
Authors: Alanazi Mohammed Jazaa , AlFaleh Ahmed Faleh
Published: July 2022

Case: Cavernous hemangioma, an uncommon benign vascular lesion, can affect different joints. It generally presents as atraumatic swelling over the joint with normal radiographic findings. We present a case of a healthy 5-year-old girl with chronic knee pain over the anteromedial aspect following minor trauma. Conclusion: The patient underwent all baseline blood investigations and plain radiograph of her knee, all of which were normal. Magnetic resonance imaging showed hemangioma. Surgical excision was performed and histological studies confirmed a cavernous hemangioma. Delayed diagnosis may increase the risk of invading and damaging the joint resulting in further morbidities.
Integrated Flood Studies in Sicily: An Hydro-Geomorphological Approach
Authors: Francesco Silvia Di , carlino martina
Published: July 2022

The present study originates from the need to investigate and monitor rivers in order to manage and mitigate fluvial dynamics and prevent flood adverse effects. The aim is to develop an integrated flood risk management procedure that properly incorporates safety and quality issues, in accordance respectively with Flood Directive and Water Framework Directive (WFD). Flood inundation models (2‐D) were used to develop flood inundation maps that takes into account uncertainty related to modeling process and hazards related to channel dynamics were investigated. Two survey and classification tools, recently developed in the IDRAIM methodology, were tested: the Morphological Dynamics Index (MDI) and the Event’s Dynamics Classification ( EDC ). These latter tools are required for integrating the standard hydraulic analyses used for flood mapping and, therefore, for obtaining an overall more robust and reliable flood risk assessment.Hydraulic simulations and applications of morphological indexes were applied on two different rivers located in Sicily: a highly controlled river, Arena river, and a more dynamic gravel-bed river, Tempio river. Specifically, the indexes were used to identify portions of river interested by morphologic variability. Based on obtained results, interventions addressed to mitigate fluvial dynamics and prevent flood adverse effects were designed.
Case Report: Pasteurella Multocida as a Pathogen of Peritonitis
Authors: Maksymyuk Valentina , Rao Edwina , Sarvepalli Satish
Published: July 2022

Although there are several published case reports of Pasteurella multocida bacterial peritonitis in patients on ambulatory peritoneal dialysis and patients with liver cirrhosis and ascites, it is a rare occurrence. In this article, we present another case of Pasteurella multocida peritonitis in a patient dependent on peritoneal dialysis. The patient owned two pet cats and we suspect the cats were a source for the infectious pathogen. She was treated with IV ampicillin-sulbactam, intraperitoneal ceftazidime, and transitioned to oral amoxicillin-clavulanate. Peritonitis accounts for a significant percentage of patient deaths among peritoneal dialysis patients. We emphasize the importance of starting the patient on appropriate antibiotics, educating the patient on appropriate hygiene of peritoneal dialysis equipment, and situations that necessitate possible removal of the peritoneal dialysis catheter.
Recurring Suboptimal Choices Result in Superior Decision Making
Authors: Traczyk Jakub , Mondal Supratik , Lenda Dominik
Published: July 2022

In real-life situations involving risk and uncertainty, optimal policy hinges on selecting a course of action characterized by the highest expected value (i.e., future outcomes weighted by their probabilities). Nevertheless, a vast body of findings from economic and psychological studies indicate that people rarely follow this principle and make suboptimal choices. In the current research, we tested a hypothesis that recurring suboptimal choices result in superior decision making. In one simulation study and three well-powered (N = 1,046) fully-incentivized empirical studies, we demonstrated that people who traded off their decision accuracy for the number of possible choices performed better (i.e., they earned more money) than those who made optimal decisions in terms of maximizing the expected value. Our results demonstrate that decision makers can adapt to the requirements of a decision task. They are inclined to make more suboptimal decisions, resulting in better overall performance than normatively better choices.
Image-based Finite-time Visual Servoing of a Quadrotor for Tracking a Moving Target
Authors: He Wei , Yuan Liang
Published: July 2022

This paper proposes an image-based visual servoing control method for a moving target of a quadrotor UAV (QUAV). Firstly, the dynamic image model with moving target parameters is established based on the image moment features in the virtual camera plane. For the unpredictability of the moving target in space, we use a high-order differentiator to estimate the state parameters of the moving target. In order to solve the problem of image depth information caused by a monocular camera, we derive a nonlinear finite-time linear velocity observer from the virtual image plane, which can not only estimate the linear velocity information of QUAV but also avoid the measurement of image depth. Based on the above information, we design the global finite-time controller and use Lyapunov theory to prove the finite-time stability of the system. Finally, the numerical simulations verify the convergence of the proposed control scheme, and the ROS gazebo simulations demonstrate the improved performance of the proposed control scheme in tracking error.