bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of rhythmic stimuli with spatial information on sensorimotor synchronization: an EEG and EMG study
Authors: Zhang Huanqing , Xie Jun , Tao Qing , Ge Zengle , Xiong Yu , Xu Guanghua , Li Min , Han Chengcheng
Published: October 2024

Introduction

Sensorimotor synchronization (SMS) is the human ability to align body movement rhythms with external rhythmic stimuli. While the effects of rhythmic stimuli containing only temporal information on SMS have been extensively studied, less is known about how spatial information affects SMS performance. This study investigates the neural mechanisms underlying SMS with rhythmic stimuli that include both temporal and spatial information, providing insights into the influence of these factors across different sensory modalities.

Methods

This study compared the effects temporal information and spatial information on SMS performance across different stimuli conditions. We simultaneously recorded the electroencephalogram (EEG), the electromyogram (EMG), and behavioral data as subjects performed synchronized tapping to rhythmic stimuli. The study analyzed SMS performance under conditions including auditory, visual, and auditory-visual motion stimuli (containing both temporal and spatial information), as well as auditory, visual, and auditory-visual non-motion stimuli (containing only temporal information). Specifically, the research examined behavioral data (i.e., mean asynchrony, absolute asynchrony, and variability), neural oscillations, cortico-muscular coherence (CMC), and brain connectivity.

Results

The results demonstrated that SMS performance was superior with rhythmic stimuli containing both temporal and spatial information compared to stimuli with only temporal information. Moreover, sensory-motor neural entrainment was stronger during SMS with rhythmic stimuli containing spatial information within the same sensory modality. SMS with both types of rhythmic stimuli was found to be dynamically modulated by neural oscillations and cortical-muscular coupling in the beta band (13-30 Hz).

Discussion

These findings provide deeper insights into the combined effects of temporal and spatial information, as well as sensory modality, on SMS performance. The study highlights the dynamic modulation of SMS by neural oscillations and CMC, particularly in the beta band, offering valuable contributions to understanding the neural basis of sensorimotor synchronization.
A study investigating how the albumin-globulin ratio relates to depression risk within U.S. adults: a cross-sectional analysis
Authors: Xu Qi , Wang Jiale , Li Hanzhi , Chen Xiaohui
Published: October 2024

Background

The relationship between the albumin-to-globulin ratio (AGR) and depression is not well understood. This analysis aims to investigate the relationship between AGR in conjunction with depression in U.S. adults.

Methods

This study analyzed information from 31,363 individuals collected by NHANES during the years 2005 to 2018. The PHQ-9 scale was employed to gauge depression, where a score of 10 or above signified depression. Weighted multivariable logistic modeling along with smooth curve fitting were applied to explore the AGR-depression connection. To confirm our findings, we carried out sensitivity analyses, subgroup analyses, and interaction tests.

Results

After adjusting for confounding variables, a higher AGR is associated with a lower risk of depression (OR = 0.61, 95% CI: 0.47–0.79). Dividing AGR into quartiles revealed that participants in the highest quartile (Q4) of AGR had a markedly lower risk of depression than those in the lowest quartile (Q1) (OR = 0.64, 95% CI: 0.53–0.77). Using smooth curve fitting, we suggested a possible linear inverse association connecting AGR with depression. Further subgroup and sensitivity analyses supported these findings, although factors such as diabetes and hypertension might influence the relationship.

Conclusion

Our findings indicate that elevated AGR levels correlate with a lower risk of depression. The findings suggest AGR as a potential biomarker for depression screening and prevention. Further studies are required to determine causality and clarify the mechanisms between AGR and depression.
Effects of quinoa on cardiovascular disease and diabetes: a review
Authors: Zhang He , Li Ruiqi
Published: October 2024

Quinoa is an annual dicotyledonous plant belonging to the genus Chenopodiaceae. As a functional healthy food with outstanding nutritional value, quinoa contains not only a balanced proportion of amino acids but also higher contents of protein, unsaturated fatty acids, vitamins, and minerals (K, P, Mg, Ca, Zn, and Fe) than most cereal crops. Quinoa is also rich in active ingredients, such as polyphenols, flavonoids, saponins, polysaccharides, peptides, and ecdysone, which provide balanced nutrition, enhance the body function, regulate blood sugar, decrease blood lipid, increase anti-oxidation and anti-inflammatory action, and prevent and treat cardiovascular diseases. Thus, quinoa is especially suitable for people suffering from chronic diseases, such as diabetes, hypertension, hyperlipidemia, and heart disease, and for the elderly people. Because of its comprehensive nutritional value and edible functional characteristics, quinoa is better than most grains and has become a highly nutritious food suitable for human consumption. This article reviews the active ingredients and physiological functions of quinoa, aiming to provide a reference for further research and its utilization in food, healthcare, and pharmaceutical research and development.
Detecting two Schistosoma circulating antigens – CCA and CAA – in urine and serum to improve diagnosis of human schistosomiasis
Authors: Hoekstra Pytsje T. , de Dood Claudia J. , Abdoel Theresia , Hilt Stan , van Diepen Angela , Polman Katja , Kremsner Peter , van Lieshout Lisette , Kreidenweiss Andrea , Adegnika Ayola Akim , Fusco Daniela , Rasomoelina Tahinamandranto , Rakoto Andrianarivelo Mala , Rakotozandrindrainy Raphaël , Rakotoarivelo Rivo Andry , Sicuri Elisa , van Dam Govert J. , Corstjens Paul L. A. M.
Published: October 2024

Background

Schistosomiasis is caused by infection with parasitic Schistosoma worms and affects more than 250 million people globally. The detection of schistosome derived circulating cathodic and anodic antigens (CCA and CAA) has proven highly valuable for detecting active Schistosoma infections, causing both intestinal and urinary schistosomiasis.

Aim

The combined detection of CCA and CAA was explored to improve accuracy in detecting Schistosoma infections.

Methods

Parallel detection of CCA and CAA was performed on two banked sample sets with matching serum and urine samples from Schistosoma mansoni (Sm) and S. haematobium (Sh) infected individuals using the non-concentration based lateral flow (LF) test comprising the sensitive luminescent up-converting reporter particle (UCP) technology.

Results

Parallel detection of CCA and CAA increased the positivity rate for detecting both Sm and Sh infections compared to the detection of either antigen separately, demonstrating the added value of detecting both antigens in a single sample to confirm diagnosis, independent from the Schistosoma species. Significantly higher CCA concentrations in urine were observed in Sm infected individuals compared to Sh infected individuals, while serum CCA-concentrations were similar between species. CAA concentrations were higher in serum compared to those in urine, irrespective of species. When exploring the relationship of CCA and CAA in urine, the CCA/CAA ratio in Sm infected individuals was significantly higher than in Sh infected individuals, while no differences were observed in serum.

Discussion and conclusion

Parallel detection of CCA and CAA via the UCP-LF platform showed added diagnostic value through an increased positivity rate for the detection of Sm and Sh infections, compared to only detecting either of the antigens. The combined and quantitative detection of CCA and CAA is indicative for identifying the infecting species, but needs further exploration.
Effects of probiotics on the prevention and treatment of children with allergic rhinitis: a meta-analysis of randomized controlled trials
Authors: Luo Xinyi , Wang Huan , Liu Huixia , Chen Yue , Tian Li , Ji Qing , Xie Dengpiao
Published: October 2024

Background and aim

Recent studies have demonstrated the anti-allergic effects of probiotics in humans. However, their role in preventing and treating pediatric allergic rhinitis has not been thoroughly investigated. This study aimed to systematically review the efficacy and preventive effects of probiotics on pediatric allergic rhinitis.

Methods

We systematically searched PubMed, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science databases for all relevant studies on probiotics and pediatric allergic rhinitis. Studies meeting the inclusion criteria were included, data were extracted, and meta-analyses were performed.

Results

A total of 28 studies with 4,765 participants were included in this study. The pooled results showed that the use of probiotics was associated with a significant improvement in total nose symptom scores (SMD, −2.27; 95% CI, −3.26 to −1.29; P < 0.00001), itchy nose scores (SMD, −0.44; 95% CI, −0.80 to −0.07; P = 0.02), sneezing scores (SMD, −0.47; 95% CI, −0.84 to −0.10; P = 0.01), eye symptoms (SMD, −3.77; 95% CI, −5.47 to −2.07; P < 0.00001), and Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (SMD, −2.52; 95% CI, −4.12 to −0.92; P < 00001). However, the use of probiotics was not associated with the incidence of allergic rhinitis (RR, 0.9; 95% CI, 0.74–1.08; P = 0.26).

Conclusions

The present study demonstrated that probiotics were effective and safe for improving pediatric allergic rhinitis symptoms and quality of life. However, probiotics could not prevent pediatric allergic rhinitis.
Paediatric rheumatology in Nigeria: history, challenges and the future
Authors: Faleye Ayodele
Published: October 2024

Pediatric rheumatology is a relatively new subspecialty in Nigeria. For many years, rheumatic disease had not been well-recognized or studied in Nigeria, so there has been a low suspicion index. The clinical presentation of most pediatric rheumatic diseases (PRDs) mimics non-rheumatic diseases making it a diagnostic challenge most of the time. The story has changed in Lagos since the creation of a pediatric rheumatology unit at the Lagos State University Teaching Hospital. There is now a high index of suspicion for these diseases in the hospital but no one knows about what is happening in the other 35 states of the country who do not have a pediatric rheumatologist. Major challenges being faced presently are poor awareness among healthcare workers and the community, high cost of investigations and medications, lack of pediatric rheumatologists in most hospitals in the country, lack of pediatric rheumatology training centers for both undergraduate and postgraduate training, and lack of research data. The healthcare community in Nigeria is looking forward to a future where pediatric rheumatology will be highly recognized and established.
Case Report: Reiterating the importance of tissue biopsy in the diagnosis of tuberculosis: lessons from a case of pediatric pulmonary tuberculosis complicated by Hodgkin's lymphoma
Authors: Luo Yonghan , Yang Xiaotao , Zhou Jun , Pu Shuangqiong , Wang Yanchun
Published: October 2024

The clinical symptoms of tuberculosis infection in children are not typical and need to be distinguished from many diseases, and the tumor is one of them. We present a case of cervical lymphadenopathy in a child with positive purified protein derivative (PPD) and Interferon-Gamma Release Assay results, ultimately diagnosed with Hodgkin's lymphoma via cervical lymph node biopsy. We learned some lessons from the case: First, Pathological biopsy remains the “gold standard” for diagnosing tuberculosis. Second, there are limitations of sampling in lump fine needle aspiration biopsy, surgical methods for lymph node are preferred to obtain larger tissues and improve tuberculosis detection sensitivity.
Pharmacophylogenetic relationships of genus Dracocephalum and its related genera based on multifaceted analysis
Authors: Liu Haolin , Feng Xiaowei , Zhao Yulian , Lv Guoshuai , Zhang Chunhong , Aruhan  , Damba Tsend-Ayush , Zhang Na , Hao Dacheng , Li Minhui
Published: October 2024

The Lamiaceae genus Dracocephalum, with over 30 species, is believed to have considerable medicinal properties and is widely used in Eurasian ethnomedicine. Numerous studies have researched on the geographical distribution, metabolite identification, and bioactivity of Dracocephalum species, especially amidst debates concerning the taxonomy of its closely related genera Hyssopus and Lallemantia. These discussions present an opportunity for pharmacophylogenetic studies of these medicinal plants. In this review, we collated extensive literature and data to present a multifaceted view of the geographical distribution, phylogenetics, phytometabolites and chemodiversity, ethnopharmacological uses, and pharmacological activities of Dracocephalum, Hyssopus, and Lallemantia. We found that these genera were concentrated in Europe, with species adapted to various climatic zones. These genera shared close phylogenetic relationships, with Dracocephalum and Hyssopus displaying intertwined patterns in the phylogenetic tree. Our review assessed more than 900 metabolites from these three genera, with terpenoids and flavonoids being the most abundant. Researchers have recently identified novel metabolites within Dracocephalum, expanding our understanding of its chemical constituents. Ethnopharmacologically, these genera have been traditionally used for treating respiratory, liver and gall bladder diseases. Extracts and metabolites from these genera exhibit a range of pharmacological activities such as hepatoprotective, anti-inflammation, antimicrobial action, anti-hyperlipidaemia, and anti-tumour properties. By integrating phylogenetic analyses with network pharmacology, we explored the intrinsic links between metabolite profiles, traditional efficacy, and modern pharmacology of Dracocephalum and its related genera. This study contributes to the discovery of potential medicinal value from closely related species of Dracocephalum and aids in the development and sustainable use of medicinal plant resources.
Sinusoidal LED light recipes can improve rocket edible biomass and reduce electricity costs in indoor growth environments
Authors: Stamford John D. , Hofmann Tanja A. , Lawson Tracy
Published: October 2024

Accumulation of edible biomass by crop plants relies on maintenance of a high photosynthetic rates across the photoperiod, with assimilation rate (A) generally responding to increasing light intensity in a hyperbolic fashion. In natural environments light fluctuates greatly over the course of the day, however in Controlled Environmental Agricultural (CEA) systems, light intensity can be supplemented or precisely controlled using LEDs to create near optimum conditions. In such indoor growth environments light is often delivered as a square wave and recommendations to horticulturalists are given in the form of Daily Light Integrals (DLI). However, this does not take into account the slow photosynthetic induction at the start of the photoperiod and the decline of A towards the end of the photoperiod, which has been demonstrated by several previous studies. Square wave light regimes therefore potentially cause suboptimal photosynthetic utilization of the applied lighting and waste electricity. Here we have adapted light recipes to gradually increase and decrease in intensity to take account of these findings. We demonstrate that, utilising a sinusoidal light regime capped at 250 μmol m-2 s-1, it is possible to increase edible biomass of rocket (by ca. 20%) compared to square wave delivered at 250 at the same DLI. Additionally, this can be achieved using less electricity (0.6%), therefore reducing energy costs and improving profitability. We suggest that capping maximum light intensity at 250 µmol m-2 s-1 improves the operating efficiency of PSII photochemistry (Fq’/Fm’) also known as the photosynthetic efficiency by maintaining A later in the photoperiod. We show that a higher electron transfer rate (ETR) is maintained in these treatments over the photoperiod compared to higher light intensity caps, resulting in a greater Daily Photochemical Integral (DPI). We attribute this to less NPQ due to a greater sink capacity for the end products of electron transport, ATP and NADPH, as A is kept high for longer.
A combination of joint linkage and genome-wide association study reveals putative candidate genes associated with resistance to northern corn leaf blight in tropical maize
Authors: Ndlovu Noel , Gowda Manje , Beyene Yoseph , Das Biswanath , Mahabaleswara Suresh L. , Makumbi Dan , Ogugo Veronica , Burgueno Juan , Crossa Jose , Spillane Charles , McKeown Peter C. , Brychkova Galina , Prasanna Boddupalli M.
Published: October 2024

Northern corn leaf blight (NCLB), caused by Setosphaeria turcica, is a major fungal disease affecting maize production in sub-Saharan Africa. Utilizing host plant resistance to mitigate yield losses associated with NCLB can serve as a cost-effective strategy. In this study, we conducted a high-resolution genome-wide association study (GWAS) in an association mapping panel and linkage mapping with three doubled haploid (DH) and three F3 populations of tropical maize. These populations were phenotyped for NCLB resistance across six hotspot environments in Kenya. Across environments and genotypes, NCLB scores ranged from 2.12 to 5.17 (on a scale of 1–9). NCLB disease severity scores exhibited significant genotypic variance and moderate-to-high heritability. From the six biparental populations, 23 quantitative trait loci (QTLs) were identified, each explaining between 2.7% and 15.8% of the observed phenotypic variance. Collectively, the detected QTLs explained 34.28%, 51.37%, 41.12%, 12.46%, 12.11%, and 14.66% of the total phenotypic variance in DH populations 1, 2, and 3 and F3 populations 4, 5, and 6, respectively. GWAS, using 337,110 high-quality single nucleotide polymorphisms (SNPs), identified 15 marker–trait associations and several putative candidate genes linked to NCLB resistance in maize. Joint linkage association mapping (JLAM) identified 37 QTLs for NCLB resistance. Using linkage mapping, JLAM, and GWAS, several QTLs were identified within the genomic region spanning 4 to 15 Mbp on chromosome 2. This genomic region represents a promising target for enhancing NCLB resistance via marker-assisted breeding. Genome-wide predictions revealed moderate correlations with mean values of 0.45, 0.44, 0.55, and 0.42 for within GWAS panel, DH pop1, DH pop2, and DH pop3, respectively. Prediction by incorporating marker-by-environment interactions did not show much improvement. Overall, our findings indicate that NCLB resistance is quantitative in nature and is controlled by few major-effect and many minor-effect QTLs. We conclude that genomic regions consistently detected across mapping approaches and populations should be prioritized for improving NCLB resistance, while genome-wide prediction results can help incorporate both major- and minor-effect genes. This study contributes to a deeper understanding of the genetic and molecular mechanisms driving maize resistance to NCLB.
Artificial macropores improve maize performance at the seedling stage under poor aeration
Authors: Xiong Peng , Jiang Fahui , Wang Yuekai , Zhang Zhongbin
Published: October 2024

Maize is susceptible to hypoxia stress in soils with poor aeration, but the macropores have the potential to improve soil aeration. We studied the impact of artificial macropores on maize performance under poor aeration. Three levels of air-filled porosity (5%, 10% and 15%) were established, and soil columns with (28 vertical artificial macropores with 0.5 mm diameter) or without macropores were created for each level of air-filled porosity with a bulk density of 1.3 g cm-3. Root–macropore interactions were visualized using CT scanning (41 μm in resolution). Our results showed that root length density significantly increased by 114%, as air-filled porosity increased from 5% to 15%. However, when artificial macropores were present, an increase in air-filled porosity had no significant effect on root length density. The treatment of 5% air-filled porosity with macropores significantly increased root length density and root biomass by 108% and 65%, respectively, relative to the treatment of 5% air-filled porosity without macropores, whereas there was no significant difference in root growth between the treatments of 15% air-filled porosity with and without macropores. Compared to the treatment of 5% air-filled porosity with macropores, there was a significant reduction of 49% in the number of macropores colonized by roots under the treatment of 15% air-filled porosity with macropores. Our results demonstrate that macropores provide preferential paths for the colonization of maize roots, thereby promoting root growth under poor aeration. Creating macropores with bio-tillage can serve as a crucial strategy for enhancing crop performance in poorly aerated soils.
The OsGAPC3 mutation significantly affects grain quality traits and improves the nutritional quality of rice
Authors: Peng Bo , Liu Yan , Sun Xiaoyu , Zhao Qiang , Qiu Jing , Tian Xiayu , Peng Jing , Zhang Zhiguo , Wang Yujian , Huang Yaqin , Pang Ruihua , Zhou Wei , Qi Yuliang , Sun Yanfang , Wang Quanxiu , He Yuqing
Published: October 2024

The glycolytic enzyme cytoplasmic glyceraldehyde-3-phosphate dehydrogenase (GAPC3) is involved in multiple biological processes in plants, including transcriptional regulation, and material metabolism. However, the relationship between OsGAPC3 and the quality traits of rice is poorly understood. Here we identify OsGAPC3 mutations that enhance the protein content and grain nutritional quality of rice by regulating the OsAAP6 gene expression. The number and volume of type-II protein bodies in the endosperm of the OsGAPC3 mutants, and GPC increase significantly. We report significant increases in chalkiness area and degree, and decreases for starch content, gel consistency, and taste value. Results of proteomic detection and analysis reveal that OsGAPC3 affects the major storage substances (proteins and starch) metabolism in rice, and the accumulation of proteins and starch in the endosperm. Additionally, the OsGAPC3 mutation significantly decreases the rice-seedling salt tolerance. Therefore, OsGAPC3 affects multiple quality traits of rice, participates in regulating rice-seedling salt-stress response. These data can be used to design better-quality and stronger salt-resistant rice varieties.
Mapping acceptance: micro scenarios as a dual-perspective approach for assessing public opinion and individual differences in technology perception
Authors: Brauner Philipp
Published: October 2024

Understanding public perception of technology is crucial to aligning research, development, and governance of technology. This article introduces micro scenarios as an integrative method to evaluate mental models and social acceptance across numerous technologies and concepts using a few single-item scales within a single comprehensive survey. This approach contrasts with traditional methods that focus on detailed assessments of as few as one scenario. The data can be interpreted in two ways: Perspective (1): Average evaluations of each participant can be seen as individual differences, providing reflexive measurements across technologies or topics. This helps in understanding how perceptions of technology relate to other personality factors. Perspective (2): Average evaluations of each technology or topic can be interpreted as technology attributions. This makes it possible to position technologies on visuo-spatial maps to simplify identification of critical issues, conduct comparative rankings based on selected criteria, and to analyze the interplay between different attributions. This dual approach enables the modeling of acceptance-relevant factors that shape public opinion. It offers a framework for researchers, technology developers, and policymakers to identify pivotal factors for acceptance at both the individual and technology levels. I illustrate this methodology with examples from my research, provide practical guidelines, and include R code to enable others to conduct similar studies. This paper aims to bridge the gap between technological advancement and societal perception, offering a tool for more informed decision-making in technology development and policy-making.
Community-based interventions for mitigating cognitive-linguistic decline in older adults
Authors: Tian Xiaoming , Ding Wenshu
Published: October 2024

Introduction

This study focuses on exploring the effectiveness of interventions in two community-based language rehabilitation care centers located in an economically underdeveloped region of northwest China.

Method

The research focuses on 35 older adults with cognitive-linguistic decline enrolled in both centers. The interventions provided to the participants include auditory training, sign language use enhancement, second language interest classes, and the promotion of elderly-mode applications on smartphones.

Results

The interventions were particularly effective in enhancing auditory processing and language comprehension skills. Additionally, the promotion of elderly-mode applications on smartphones proved to be a valuable tool in improving participants’ language cognition.

Conclusion

The study underscores the importance of tailored community-based interventions in improving language skills and cognition and provides a basis for further research in this area.
Psychological responses and factors associated with depression and anxiety in entry personnel under quarantine during pandemic in China
Authors: Chen Liping , Chu Qiao , Xu Chenhui , Zhou Feng , Hu Xiaolong , Wang Zhaoxin , Jin Ying , Lv Yipeng
Published: October 2024

Background

The global COVID-19 pandemic has highlighted critical concerns surrounding mental health. Social isolation measures, such as the quarantine of incoming travelers, are essential public health strategies for the prevention and control of infectious diseases. However, quarantine can lead to adverse psychological outcomes, including feelings of confinement, boredom, perceived scarcity of supplies and information, financial hardship, and social stigma. This study aims to assess the mental states of quarantined individuals, investigate the factors affecting their mental well-being, and examine their coping mechanisms, with the objective of providing recommendations to enhance mental health in anticipation of future outbreaks, such as Disease X.

Methods

We surveyed 327 individuals in quarantine from September 22, 2020 to January 9, 2021, collecting general demographic data and information related to COVID-19. Depression and anxiety were assessed using the PHQ-9 and GAD-7 scales, respectively, while stress coping was evaluated with a simplified version of the Cope scale. We analyzed the relationships between independent variables and mental health outcomes.

Results

Among the individuals undergoing entry quarantine, 27.8% reported symptoms of depression, and 20.5% reported symptoms of anxiety. Students were more likely to experience depression compared to those with permanent jobs or no occupation. Significant risk factors for both depression and anxiety included pre-existing health conditions, lack of medical insurance, concerns about shortages of daily necessities during quarantine, and high scores for “guilt and self-blame.” Additionally, participants who worried about the impact of the epidemic on their studies or work, and those with high scores for “denial,” were more likely to exhibit depressive symptoms. On the other hand, participants who were concerned about potential rejection or discrimination from the outside world after quarantine were more prone to anxiety symptoms.

Conclusion

Attention should be paid to the negative psychological reactions of the entry quarantined personnel, especially those with pre-existing health conditions, those without medical insurance, and students studying abroad. Accurate and effective epidemic dynamic information and preventive and control measures can be provided to the public to prevent fear and stigma against quarantined personnel.
Impacts of iodoacetic acid on reproduction: current evidence, underlying mechanisms, and future research directions
Authors: Ha Mei , Mou Li , Qu Jiayuan , Liu Changjiang
Published: October 2024

In light of the undeniable and alarming fact that human fertility is declining, the harmful factors affecting reproductive health are garnering more and more attention. Iodoacetic acid (IAA), an emerging unregulated drinking water disinfection byproduct, derives from chlorine disinfection and is frequently detected in the environment and biological samples. Humans are ubiquitously exposed to IAA daily mainly through drinking water, consuming food and beverages made from disinfected water, contacting swimming pools and bath water, etc. Mounting evidence has indicated that IAA could act as a reproductive toxicant and bring about multifarious adverse reproductive damage. For instance, it can interfere with gonadal development, weaken ovarian function, impair sperm motility, trigger DNA damage to germ cells, perturb steroidogenesis, etc. The underlying mechanisms predominantly include cytotoxic and genotoxic effects on germ cells, disturbance of the hypothalamic–pituitary-gonadal axis, oxidative stress, inhibition of steroidogenic proteins or enzymes, and dysbiosis of gut microbiota. Nevertheless, there are still some knowledge gaps and limitations in studying the potential impact of IAA on reproduction, which urgently need to be addressed in the future. We suppose that necessary population epidemiological studies, more sensitive detection methods for internal exposure, and mechanism-based in-depth exploration will contribute to a more comprehensive understanding of characteristics and biological effects of IAA, thus providing an important scientific basis for revising sanitary standards for drinking water quality.
Caregiver, community health worker, and dentist feedback on a behavioral intervention for caregivers of children with severe early childhood caries
Authors: Patano Paige , Borowski Teresa G. , Izquierdo Melanie , Wong Calvin , Avenetti David , Lee Helen H. , Buscemi Joanna
Published: October 2024

Introduction

Severe early childhood caries (S-ECC) is a common disease within marginalized pediatric populations. S-ECC is often treated under general anesthesia to facilitate extensive treatment in young children, but treatment does not address etiology of an infectious disease that is rooted in health behaviors. Without behavior changes related to toothbrushing and sugar consumption, many children experience recurrent disease and some require subsequent surgeries. To improve post-surgery oral health, we developed PROTECT (Preventing Recurrent Operations Targeting Early Childhood Caries Treatment), a community health worker (CHW)-delivered behavioral intervention for caregivers that focuses on children’s oral health behaviors. The purpose of this study was to use qualitative research methods to receive feedback on the planned protocol for a pilot study of PROTECT, a six-month intervention initiated at the time of a child’s surgery to treat severe early childhood caries.

Methods

Study participants included caregivers of children presenting for surgery [n = 12], CHWs [n = 8] and dentists [n = 8] in a series of audio-video recorded semi-structured interviews. Five coders used Braun and Clarke’s six-phase framework for data analysis.

Results

Participant feedback on the pilot study protocol yielded the following themes: (1) right time, population, and type of support; (2) flexible intervention delivery and content; (3) inclusion of other social determinants of health; and (4) cultural considerations. Implementing a behavioral intervention for caregivers in the immediate time during a child’s surgery for treating dental caries was widely deemed important and timely in order to affect post-surgical behavioral and clinical outcomes. Flexibility in content, timing, and communication were all named as facilitators to participant engagement and study retention. Caregivers and CHWs emphasized the relevance of addressing other social determinants of health. CHWs emphasized the importance of training in becoming aware of culture and practicing with understanding and humility, given the influence on health beliefs, behaviors, and family dynamics. Cultural considerations in intervention delivery were deemed an important factor for participant retention and engagement.

Discussion

Participant feedback led to critical modifications of the pilot study protocol, specifically in intervention content and CHW-led delivery.
Non-communicable diseases in the world over the past century: a secondary data analysis
Authors: Taheri Soodejani Moslem
Published: October 2024

Introduction

We analyzed the changes in the top 10 non-communicable diseases (NCDs) over the past century across the World Health Organization (WHO) regions.

Materials and methods

The data were extracted from the Global Burden of Disease (GBD) studies. After we accessed this source, all NCDs were sorted according to their prevalence in 2019, and the 10 most common NCDs were selected. Then, the incidence, prevalence, and mortality rates of these 10 NCDs were compared to the rates in 2000.

Results

Diabetes and kidney disease had the highest increase in incidence (49.4%) and prevalence (28%) in the Eastern Mediterranean region. Substance use disorders had a huge increase (138%) in the mortality rates among women in the Americas region. On the other hand, women in Southeast Asia experienced the greatest decrease in incidence (−19.8%), prevalence (−15.8%), and mortality rates (−66%).

Conclusion

In recent years, nearly all NCDs have shown an increase, yet mortality rates have declined across all regions. Lifestyle can be a major cause of this increase, but advancements in health and medical services, such as screening and treatment, have played a crucial role in improving survival rates.
The association between physical activity and anxiety in college students: parallel mediation of life satisfaction and self-efficacy
Authors: Deng Jiaxin , Liu Yongfeng , Wang Tong , Li Weicheng
Published: October 2024

Objective

To explore the functions that physical activity (PA), life satisfaction, and self-efficacy have in the process of coping with anxiety among Chinese college students, and to explore the mediating role of life satisfaction and self-efficacy in this process.

Methods

Participants were 358 college students (186 males, 172 females, mean age 20.88, SD = ±1.80). Psychosocial tests including the Physical Activity Rating Scale (PARS-3), College Student Life Satisfaction Scale (CSLSS), General Self-Efficacy Scale (GSES), and Generalized Anxiety Disorder Scale (GAD-7) were completed. Correlations between variables were calculated using Pearson’s test. The mediation model was tested using the SPSS 26.0 PROCESS macro and regression bootstrap.

Results

Physical activity showed a negative correlation with anxiety (β = −0.1617, p < 0.001., life satisfaction and self-efficacy played a role in the relationship between physical activity and anxiety. More importantly, physical activity was associated with anxiety through parallel mediating effects of life satisfaction and self-efficacy, with a total mediating effect of 55.34%.

Conclusion

By increasing college students’ participation in physical activity, it helps to promote the growth of their life satisfaction and self-efficacy, which is the key to reducing anxiety and promoting college students’ mental health.
A case for microbial therapeutics to bolster colony health and performance of honey bees
Authors: Killam Sophie M. , Daisley Brendan A. , Kleiber Morgan L. , Lacika Julia F. , Thompson Graham J.
Published: October 2024

The holobiont theory of evolution explains how individuals are deeply symbiotic with their gut microbes, such that microbes are adapted to influence host metabolism, immunity and behaviour, as signalled from the gut to the brain. For eusocial taxa like the Western honey bee (Apis mellifera), this brain-gut axis may scale up from the individual to affect entire colonies. Here, we examine how microbial supplementation of honey bee feeds could manipulate the brain-gut axis to affect hygienic and other social behaviours relevant to beekeeping, such as foraging, recruitment (dance language) and defence. To illustrate this concept, we focus on various lactic acid-producing bacteria that can synthesize neurotransmitters such as octopamine, dopamine, serotonin and γ-aminobutyric acid, which can influence an individual bee’s behavioural cycles and responsiveness to environmental cues. If the behaviour of a worker bee can be deliberately manipulated, and this effect multiplied across many workers, microbial neurotherapeutics could conceivably render colonies more behaviourally responsive to symptoms of disease, or more motivated to forage or possibly less aggressive towards beekeepers. Drawing from the scientific literature, we infer how microbial supplements, such as neurostimulatory or neurosuppressive probiotics, could be applied or even engineered to co-opt the brain-gut axis to bolster colony health or improve performance. The mechanistic link between the gut microbiota and the collective social behaviour of single colonies remains an understudied aspect of honey bee social biology with relevance to apiculture.
A pilot study to establish feasibility and acceptability of a yoga and self-management education intervention to support caregivers and care receivers with persistent pain
Authors: Schmid Arlene A. , Fruhauf Christine A. , Fox Aimee L. , Sharp Julia L. , Portz Jennifer Dickman , Leach Heather J. , Van Puymbroeck Marieke
Published: October 2024

Introduction

Approximately 75% of caregivers providing unpaid care to family members or friends experience persistent pain. Simultaneously, individuals who require caregiving commonly experience pain. The inherent complexity of pain is enhanced by relationship dynamics of two closely tied individuals (i.e., caregiving dyad = caregivers and care recipients). Currently there are no proven pain interventions that target the caregiving dyad. Thus, the purpose of this pilot study was to assess the feasibility of a new behavioral multi-modal intervention, the Merging Yoga and self-management to develop Skills (MY-Skills) intervention.

Methods

Each participant was part of a caregiving dyad and all participants had moderate to severe musculoskeletal pain, a score of ≥4 of 6 on the short mini-mental status exam, were ≥18 years old, sedentary, able to speak English, able to stand, and living at home. Participants were randomized to MY-Skills or the control group. MY-Skills was offered twice a week for eight weeks and each two-hour session included yoga and self-management education developed specifically for caregiving dyads experiencing persistent pain. MY-Skills was group based and developed as an in-person intervention. Due to Covid-19, the intervention was moved online and data are presented for in-person and online cohorts. Benchmarks for feasibility were set a priori, addressing: recruitment, attrition, attendance, safety, acceptability/satisfaction, and study completion.

Results

Thirteen participants completed the in-person MY-Skills intervention (caregivers n = 7, care-receivers n = 6) and 18 individuals completed the online MY-Skills intervention (9 dyads). Most participants had pain for ≥10 years. Recruitment and attrition benchmarks for the in-person intervention were not met; yet they were met for the online version. In-person and online MY-Skills intervention attendance, safety, acceptability/satisfaction, and completion exceeded benchmark criteria.

Discussion

The MY-Skills intervention appears feasible and acceptable, however changes to recruitment criteria are necessary. Additional testing and larger sample sizes are required to test efficacy.

Trial registration

Clinicaltrials.gov, #NCT03440320.
Environmental footprints in divergent cuisines: a case study of eight Chinese culinary traditions
Authors: Zheng Jiaqi , Yang Huijing , Li Shanghong , Chai Li
Published: October 2024

The sustainable dietary transitions must account for the varied culinary traditions and regional food cultures to ensure a balanced and culturally sensitive approach. This study aims to explore the impact of regional preferences on culinary culture and examine ways to achieve environmentally friendly dietary transitions in China by considering the differences in the environmental burdens of various cuisines. We investigate the eight Chinese culinary traditions and depict their respective popularity in China at the city level via POI characterization based on ArcGIS. Water, carbon, and ecological footprints are selected to investigate the environmental performance of each type of cuisine. Results show that the eight cuisines vary significantly in spreads of influence and environmental performances. Chuan cuisine is the most widely disseminated cuisine with a relatively low environmental burden. The remaining seven cuisines have limited spreads of influence and are mainly distributed in small cultural regions and the surrounding areas. Hui Cuisine, Zhe Cuisine, and Min Cuisine have the worst environmental performances. This study reveals the significant impact of regional cuisines on the environmental footprint of diets and highlights the necessity of considering this impact when promoting dietary transition, especially in culturally diverse countries.
From profitability to trust: factors shaping digital agriculture adoption
Authors: Yeo M. Lisa , Keske Catherine M.
Published: October 2024

Digital agriculture supports farmers’ decision making to improve productivity and profitability. However, adoption of digital technology is uneven. Through interviews with 21 medium acreage almond growers and crop consultants in California’s Central Valley, we examine barriers to adoption through the lens of technology acceptance models, Technology Acceptance Model (TAM-3) and Unified Theory of Acceptance and Use of Technology (UTAUT-2). Not surprisingly, farmers are willing to adopt technology when profitability and ease of use are shown, with economic returns (either anticipated or demonstrated) from the technology investment serving as the primary factor influencing adoption. Trust operates as a moderating factor to the desire for economic returns that influences adoption. There may be trust, or lack of trust, in technology performance or in the advisors who recommend it. Producer trust is affected by expectations of technology relevance and usefulness, and it is influenced by prior experience. Concerns about data management (e.g., governance, quality, privacy, security) take a back seat to more practical issues such as profitability, leaving producers in an imbalanced position with tech companies who have an interest in their agricultural data. We assert that producer acceptance of data management practices (despite their uncertainty in how to utilize the data being generated) implies that there is a basic level of trust in tech companies’ data management practices that is consistent with models of moralistic trust behaviors for precision ag adoption. Our findings contribute to the growing research on digital agriculture that debates the benefits and downsides of digital agriculture.
Comparison of the efficacy of tibial transverse transfer and periosteal distraction techniques in the treatment of diabetic foot refractory ulcers
Authors: Yang Yang , Chen Fang , Chen Yiguo , Wang Wei
Published: October 2024

Objective

To investigate the efficacy of comparing tibia transverse transport (TTT) and periosteal distraction in treating diabetic foot ulcers.

Methods

A retrospective analysis of 19 patients with diabetic foot ulcers treated with both procedures between February 2020 and November 2022, 8 of whom were treated with the tibial transverse transfer technique (transfer group) and 11 with the osteochondral distraction technique (distraction group), was performed to compare and analyze the clinical efficacy of the two methods.

Results

All wounds were healed in both groups, and the healing time ranged from 15 to 41days with a mean of 28d. The limb preservation rate was 100%. The operative time, intraoperative bleeding, and pain score in the operative area were significantly less in the distraction group than in the removal group, with statistically significant differences (P < 0.05). Intra-group comparison between the two groups of patients after surgery revealed that the skin temperature, ABI, TcPO2, SWM and VAS of the affected limb were significantly improved compared with those before surgery, and the difference was statistically significant (P < 0.05). The expression levels of VEGF, bFGF, EGF and PDGF were significantly higher than before surgery in both groups, and the difference was statistically significant (P < 0.05). No statistically significant differences were found in skin temperature, ABI, TcPO2, SWM, VAS, VEGF, bFGF, EGF and PDGF between the two groups at the corresponding time points preoperatively and postoperatively (P > 0.05).

Conclusions

The Periosteal distraction technique can significantly promote the healing of diabetic foot ulcers. It has the same efficacy as TTT in promoting the healing of diabetic foot ulcer wounds and improving the peripheral circulation of affected limbs. In addition, the periosteal distraction technique has the advantages of small trauma, simple operation, few complications, and convenient nursing care.
The impact of preoperative fasting time on patients undergoing partial nephrectomy and analysis of risk factors for postoperative hemorrhage
Authors: Wang Chunji , Cui Jiazhao , Gao Zihui
Published: October 2024

Objective

This study investigates the impact of preoperative fasting time on patients undergoing partial nephrectomy and analyzes the risk factors for postoperative hemorrhage to provide clinical reference for physicians treating patients undergoing partial nephrectomy.

Methods

A retrospective analysis was conducted on 74 patients who underwent partial nephrectomy for renal tumors between January 2022 and March 2024. Baseline and perioperative data were collected. The effects of long-term and short-term preoperative fasting on patients undergoing partial nephrectomy were compared. Additionally, univariate and multivariate logistic regression analyses were performed to identify risk factors for hemorrhagic complications following partial nephrectomy.

Results

Among the patients in this study, 26 (35.14%) underwent short-term preoperative fasting, while 48 (64.86%) underwent long-term preoperative fasting. The hemoglobin difference in the short-term fasting group was 21.08 ± 12.44 ml, compared to 13.65 ± 11.69 ml in the long-term fasting group, showing a statistically significant difference (p = 0.020). Differences in serum calcium (p = 0.003), serum magnesium (p = 0.031), and serum phosphorus (p = 0.001) between the short-term and long-term fasting groups were also statistically significant. Univariate and multivariate regression analyses identified the type of surgery (p = 0.050) and preoperative fasting time (p < 0.001) as independent risk factors for postoperative hemorrhage following partial nephrectomy.

Conclusion

Patients undergoing partial nephrectomy with short-term preoperative fasting experience a more significant decrease in hemoglobin compared to those with long-term fasting. The type of surgery and preoperative fasting time are independent risk factors for postoperative hemorrhage in patients undergoing partial nephrectomy.