bluuebunny/crossref_metadata_2025 huggingface dataset:
Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated
Authors: Géraldy Magalie , Morgen Michael , Sehr Peter , Steimbach Raphael R. , Ridinger Johannes , Oehme Ina , Witt Olaf , Nogueira Mauro S. , Koch Oliver , Gunkel Nikolas , Miller Aubry K. , Malz Mona
Published: December 2018

The discovery of isozyme-selective histone deacetylase (HDAC) inhibitors is critical for understanding the biological functions of individual HDACs and for validating HDACs as clinical drug targets. The isozyme HDAC10 contributes to chemotherapy resistance via inhibition of autophagic flux and has recently been described to be a polyamine deacetylase, but no studies directed toward selective HDAC10 inhibitors have been published. Herein, we disclose that the use of two complementary ligand-displacement assays has revealed unexpectedly potent HDAC10 binding of tubastatin A, which has been previously described as a highly selective HDAC6 inhibitor. We synthesized a targeted selection of tubastatin A derivatives and found that a basic amine in the cap group was required for strong HDAC10, but not HDAC6, binding. Only potent HDAC10 binders mimicked HDAC10 knockdown by causing dose-dependent accumulation of acidic vesicles in the BE(2)-C neuroblastoma cell line. Docking of inhibitors into human HDAC10 homology models indicated that a hydrogen-bond between a basic cap group nitrogen and the HDAC10 gatekeeper residue Glu272 was responsible for potent HDAC10 binding. Taken together, the presented assays and homology models provide an optimal platform for the development of HDAC10-selective inhibitors, as exemplified with the tubastatin A scaffold.
Rehabilitation therapy as a component of the complex approach to the treatment of chronic forms the pelvic inflammatory disease in women
Authors: Pestrikova T Yu , Yurasova E A , Yurasov I V
Published: December 2018

Issues of treatment and rehabilitation patients with pelvic's inflammatory diseases are still remain highly relevant, so relapses and chronic inflammation processes are worsen the prognosis for generative function in women, which is an important social and economic problem in modern time. Purpose of the study. Monitoring the effectiveness of therapeutic measures of rehabilitation step in chronic forms of this disease. Materials and methods. We examined 110 patients who handled to the clinic for women with complaints about the absence of pregnancy, of which a survey group was formed. The duration of pelvic inflammatory desiase (PID) in patients of the examination group did not exceed 2 years. The age of the patients was 25-35 years old. In patients of the examination group, according to clinical, laboratory and ultrasound ultrasound, laparoscopy, hysteroscopy and morphological findings, PID was verified including the presence of chronic endometritis and other endometrial pathology (for example, endometrial polyp, simple endometrial hyperplasia). Results. The rehabilitation stage of treatment (6 months) in patients with PID was aimed at restoring the morphofunctional potential of the tissue and eliminating the effects of secondary injuries, which include the restoration of hemodynamics and activity of the endometrial receptors. This stage of treatment is extremely important, especially for reproductive disorders. At this stage, the patients of the examination group were given hormone therapy and treatment with vasoactive drug (dipyridamole). The obtained results testified to the significance of the restoration of the vascular blood flow of the uterus and the functional layer of the endometrium. Conclusion. Rehabilitation therapy in patients with PID was primarily aimed at restoring the functional ability of the endometrium. Hormone therapy was a priority role, but at modern time, role of the vasoactive drugs that affect the blood flow in the uterus is emphasized. One of these drugs is dipyridamole, which contributes to the formation of collaterals (bypass paths) in ischemic zones. The results indicate that at the end of the 6-month rehabilitation phase, than of a three-layer endometrium was diagnosed (according to ultrasound on day 8-10 of the cycle) in 85 (77.27±4.00%) patients in the examination group.
Features of pregravid preparation in women with connective tissue dysplasia
Authors: Ilina I Yu , Dobrokhotova Yu E , Malikova V O , Chikisheva A A
Published: December 2018

The prevalence of multifactorial pathology among the population is manifested by a high frequency of extragenital pathology during pregnancy, contributing to the emergence of various combined pathological processes. Women with connective tissue dysplasia are at high risk for reproductive disorders with respect to a number of complications during pregnancy (threatened miscarriage, preeclampsia, placental insufficiency). In the period of pregravid preparation, in addition to well-known prescriptions, Selzinc® of pronounced antioxidant properties can be recommended for use, this complex has a beneficial effect on the course of pregnancy due to the replenishment of trace elements, the deficiency of which can lead to the development of various complications.
Transvaginal echography in the diagnosis of localization foci of deep infiltrative endometriosis
Authors: Said Danesh Sh , Chuprynin V D , Gus A I , Lunkov S S , Melnikov M V , Asaturova A V , Buralkina N A
Published: December 2018

The goal is to assess the sensitivity and specificity of transvaginal ultrasound (USI) in the diagnosis of localization of foci of deep infiltrative endometriosis. Materials and methods. The study included 142 patients with deep infiltrative endometriosis, who underwent surgery in the surgical department of the V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of Russian Federation in the period 2014-2016. Criteria for inclusion in the study: informed agreement of the patient, the reproductive age (from 18 to 44 years), deep infiltrative endometriosis with a confirmed histological conclusion. Exclusion criteria were malignant tumors of the pelvis and abdomen, refusal to undergo surgical treatment of deep infiltrative endometriosis, and malformations of the urogenital system. Results. Transvaginal echography in identifying the localization of foci of deep infiltrative endometriosis is highly sensitive in the diagnosis of colorectal endometriosis (88.9%) and endometriosis of the bladder (96%) with a relatively low specificity of the study (35%). The sizes of endometrial infiltrates of the intestine, retrocervical endometriosis, and bladder intraoperatively were large in comparison with the data obtained with transvaginal ultrasound. When assessing the accuracy of the diagnostic method, it was found that transvaginal ultrasound evaluates retrocervical endometriosis with an accuracy of 41.5%, endometriosis of the intestine - 37.7%, bladder - 54.8%. Conclusion. Transvaginal echography, based on a quantitative assessment of the characteristic curve by calculating the area under it, the size of the infiltrate and their localization, showed that our study have middle diagnostic quality and visualization of DIE lesions with enough specify.
Climacteric syndrome and magnesium (literature review)
Authors: Prilepskaya V N , Mgeryan A N , Mezhevitinova E A
Published: December 2018

Magnesium is one of the most important trace elements necessary for the life of the human body. It supports the normal exchange of proteins and nucleic acids (DNA and RNA), reduces spasm of the arteries, both peripheral and coronary, prevents the formation of blood clots, relaxes the uterus with hypertension, restores heart rhythm with tachycardia, contributes to the normal course of pregnancy, etc. Magnesium deficiency has a negative impact on health, especially in women in the menopause. Hypomagnesemia exacerbates the course of the main clinical manifestations and conditions characteristic of climacteric syndrome, and therefore the use of magnesium preparations in this category of patients will improve their health and quality of life.
Development of a public health emergency preparedness competency model for European Union countries
Authors: Stoto Michael A. , Savoia Elena , Nelson Christopher , Piltch-Loeb Rachael , Guicciardi Stefano , Takacs Judit , Varela Santos Carmen , Ciotti Massimo
Published: December 2018

In 2017, the European Centre for Disease Prevention and Control (ECDC) developed a competency model for individuals who work in public health emergency preparedness (PHEP) in European Union (EU) countries. The model serves as the basis for developing competency-based training programmes to support professionals in PHEP efforts at the country level. The competency model describes the knowledge and skills professionals need when working in national-level PHEP, such as preparedness committee members or their equivalents. In order to develop the model, existing competency statements were reviewed, as well as case studies and reports. Fifty-three professionals from the EU and other countries provided feedback to the model by participating in a three-stage consultation process. The model includes 102 competency, 100 knowledge and 158 skill statements. In addition to specifying the appropriate content for training programmes, the proposed common competency model can help to standardise terminology and approaches to PHEP training.
DEVELOPMENT OF IDEAS OF CONTINUITY LABOR EDUCATION (1919 - 1934)
Authors: Antypin Eugen
Published: December 2018

The article presents the results of theoretical synthesis the problem of continuity labor education of pre-schools and primary school aged children in a historical retrospective of 1919-1934. Investigation of this scientific problem will contribute the modern reforming processes in pre-school and primary school education. Nowadays we need to find ways to organize life-oriented study for pre-school and primary school aged children. We sure that historical and educational heritage will help to understand our opportunities and risks.

Research was made on proven methodology concepts of modern Ukrainian historical and pedagogical science. Using the articles of educators published during 1919-1934, we were able to dwell on the main pedagogical ideas of the problem. System and narrative principles helps us to highlight the key ideas of continuity labor education of pre-school and primary school aged children.

Author highlights the views of educational theorists and practice-men of definite period on labor education as a basis of children’s education that time. The period of 1919-1934 years, in the history of Ukrainian education, is the period of rising soviet system of education. But we understand this period like the period of transforming pre-school and primary education. This process was carried out with lots of creative ideas in labor education of pre-school and primary school aged children. The changes of development the basic ideas about the upbringing children of pre-school and primary school age in a context of practice-oriented labor education are characterized in the article.
Tingkat kesadaran dan pengetahuan pemilik anjing di kota Malang mengenai infestasi ektoparasit
Authors: Widyaputri Tiara , Titisari Nurina , Swastomo Rahadi
Published: December 2018

Anjing dan kucing merupakan hewan yang paling banyak dipelihara sebagai hewan kesayangan sebagaimana masyarakat di kota Malang. Ektoparasit seperti caplak dan pinjal seringkali menyerang anjing sehingga menyebabkan gangguan kesehatan baik pada anjing maupun pemiliknya. Pemeriksaan terhadap infestasi ektoparasit pada anjing sedianya dilakukan secara rutin. Kegiatan pengabdian masyarakat berupa pemeriksaan ektoparasit dan pemberian obat anti-ektoparasit yang dilakukan di Pawvillion dog cafe, Kota Malang dan didatangi oleh 18 orang pemilik anjing dengan total anjing yang diikutsertakan sebanyak 35 ekor. Hasil pemeriksaan ektoparasit ditemukan 2 jenis ektoparasit yaitu caplak dan pinjal. Anjing sebanyak 16 ekor telah terinfeksi ektoparasit spesies Ripichephalus sp. dan 3 ekor anjing terinfeksi pinjal Ctenocephalides sp. Evaluasi kuesioner yang telah diisi oleh pemilik anjing, diketahui bahwa pemberian obat kutu dan pembersihan lingkungan masih jarang dilakukan. Para pemilik anjing diberi selebaran berisi informasi mengenai ektoparasit sebagai media edukasi mengenai pentingnya menghindarkan anjing dari infestasi ektoparasit.
Analysis of the Graph Unit for the first grade of Middle School according to the 2015 Revised Mathematics Curriculum
Authors:   The Korea Society Of Educational Studies In Mathematics, Kim Bumi , KIM YUNMIN
Published: December 2018

This study compares the newly introduced ‘Graph’ unit in the mathematics textbook for 1st grade middle school students to the 2015 revised national curriculum. The results of the study are as follows; First, we analyzed the suitability of the definition of ‘graph’ in each textbook for the first-grade level in middle school. Second, the frequency analysis of the construction and interpretation of graphs in each textbook on context, translation, approach, type, method and evaluation questions revealed a significant statistical difference. Additionally, the results of cross-analysis by graph type, textbook areas and publishers all had significant statistical differences. Finally, we examined how various graphs were encountered in composition and interpretation activities .We then qualitatively analyzed the contexts of increase and decrease of graph and that of periodic change. This study could guide students in the development of better and ideal textbooks that can be addressed in the subsequent year in a wider variety of forms related to real life, society and natural phenomena.
Pengaruh Penggabungan Metode Outdoor Dengan Indoor Learning Menggunakan Sistem Sepur Selam
Authors: Hidayah Nikken Isnaini , Riski Vina Dwi , Kumalasari Lela , Astutiningtyas Erika Laras
Published: December 2018

Abstrak: Penelitian ini bertujuan untuk mengetahui pengaruh penggabungan metode Outdoor dengan Indoor Learning menggunakan sistem sepekan di luar sepekan di dalam (SEPUR SELAM) terhadap prestasi belajar siswa pada pokok bahasan Polinomial kelas XI IPA SMA Negeri 1 Tawangsari tahun pelajaran 2017/2018. Jenis penelitian yang digunakan adalah penelitian eksperimen semu. Data dikumpulkan menggunakan tes, dokumentasi, angket, observasi, dan wawancara. Sampel dalam penelitian ini adalah siswa kelas XI IPA 3 sebagai kelas kontrol dan XI IPA 5 sebagai kelas eksperimen. Hasil analisis uji-t menunjukkan bahwa thitung = 6,098 > ttabel = 2,288 maka  H0 ditolak. Disimpulkan bahwa terdapat pengaruh penggunaan penggabungan metode Outdoor dengan Indoor Learning menggunakan Sistem Sepekan di Luar Sepekan di Dalam (SEPUR SELAM) terdahap prestasi belajar siswa pada pokok bahasan Polinomial. Sedangkan angket respon siswa menyatakan 100% siswa tertarik dan mengalami kondisi pembelajaran yang berbeda dengan penggabungan metode Outdoor dengan Indoor Learning, sedangkan 97,4% siswa termotivasi dan tidak mengalami kejenuhan.

Kata kunci: Outdoor Learning;Indoor Learning;hasil belajar matematika

 

Abstract: His research aims to determine the effect of combining Outdoor methods with Indoor Learning using a week-long system within a week in (SEPUR SELAM) on student achievement on the subject of Polynomial class XI Science at SMA Negeri 1 Tawangsari in the academic year 2017/2018. The type of research used is experimental research. Data were collected using tests, documentation, questionnaires, observations, and interviews. The sample in this study were students of class XI IPA 3 as the control class and XI IPA 5 as the experimental class. The result of the t-test analysis shows that t count = 6.098> t table = 2.288 then H0 is rejected. It was concluded that there was an effect of using the combination of Outdoor methods with Indoor Learning using the Sepekan System outside the Week in (SEPUR SELAM) at the level of students' learning achievement on the subject of Polynomial. While the student response questionnaire stated 100% of students were interested and experienced different learning conditions with the incorporation of Outdoor methods with Indoor Learning, while 97.4% of students were motivated and did not experience saturation.

Keyword: Outdoor Learning;Indoor Learning; learning outcomes of mathematics
Meningkatkan Hasil Belajar Matematika Siswa Kelas 8 MTs Negeri Termas Kecamatan Baron Tahun Pelajaran 2017/2018 Dengan Menerapkan Pendekatan Model Arias
Authors: Komari Komari
Published: December 2018

Tujuan dari penelitian ini adalah untuk melihat apakah model pembelajaran ARIAS daapt meningkatkan hasil belajar matematika siswa kelas 8 MTs Negeri Teras Baron Kabupaten nganjuk tahun pelajaran 2017/2018. Metode penelitian yang digunakan adalah penelitian tindakan kelas, dengan jumlah sampe sebanyak 24 siswa dari MTs Negeri Termas Baron Kabupaten Nganjuk tahun pelajaran 2017/2018. Metode pengumpulan data menggunakan Teknik pengamatan dan catatn lapangan, teknik wawancara, dan studi dokumentasi. Hasil penelitian menunjukan bahwa 1) menggunakan pendekatan Model pembelajaran ARIAS dapat meningkatkan pemahaman persamaan garis lurus siswa kelas 8; 2) menggunakan pendekatan Model pembelajaran ARIAS, materi persamaan garis lurus lebih tertanam pada ingatan siswa, karena pengertian konsep tersebut diperoleh melalui konsep penemuan sendiri; 3) hasil belajar siswa lebih mengingkat di bandingkan dengan menggunakan pembelajaran tersebut; 4) aktivitas guru dalam memberikan pelajaran dan aktivitas siswa dalam mengikuti pembelajaran lebih aktif dari sebelumnya.
El rol de los estilos de socialización parental sobre la implicación escolar y el rendimiento académico.
Authors: Rodríguez Fernández Arantzazu , Revuelta Revuelta Lorena , Sarasa Maya Marta , Fernández Lasarte Oihane
Published: December 2018

Son muchas las variables analizadas en relación al ajuste escolar. Sin embargo, la cantidad de trabajos que analizan la relación entre los estilos de socialización parental y el ajuste escolar son escasos, especialmente en nuestro país. El presente trabajo pretende examinar el rol de tales estilos de socialización parental, diferenciando el del padre y el de la madre, sobre la implicación escolar y el rendimiento académico. Participaron 737 estudiantes de Secundaria del País Vasco de entre 11 y 18 años. Rellenaron la Escala de Afecto (EA-H) y Escala de Normas y Exigencias (ENE-H), el Cuestionario de Implicación Escolar (SEM) y el rendimiento se calculó a partir de la nota media en matemáticas y lenguaje. Los resultados indican que en el caso del rendimiento académico es el estilo permisivo de ambos progenitores el que influye de manera más positiva en la obtención de unas mejores calificaciones, mientras que en el caso de la implicación escolar son tanto el permisivo como el democrático del padre y de la madre (con pequeñas variaciones según la dimensión analizada) los que se asocian a una mayor implicación escolar. Se discuten las implicaciones educativas que estos resultados pueden presentar.
Language as an Eigenform and the Recursiom of Semiosis
Authors: Gasparyan D. E.
Published: December 2018

The hypothesis of this paper is that language is one more Eigenform, the “external” description of which is impossible. It follows that the application of second-order cybernetics to Eigenform might be adequate. In this article, I would like to concentrate on one relatively small aspect of the idea of Eigenform suggested by Foerster, Kauffman and Spenser-Brawn. I will use Foerster`s recursive approach namely that neither observer nor the thing observed can precede each other, but instead mutually assume each other. In my research, language would stand in the place of the observer, and in the place of the thing – the world itself. To specify further, I focus on the problem of noting, and in particular, on how signs correspond to things. Therefore, I will try to show that the sign and the object (the signifier and the signified) do not precede one another and do not exist isolated from each other, but on the contrary, condition each other. Thus, language creates the world of objects, but in turn, it is created by the world. Thus it is a model of self-referentiality, which arranges the form of language as Eigenform as the idea of “mutual referentiality,” as we see it in the relation between language and the world.
Japanese Philosophy: Approaches to a Proper Understanding
Authors: Karelova L. B.
Published: December 2018

Since the role of the Asian countries is increasing in the modern world, their philosophical traditions attract more and more attention. Due to this trend, a more complete panoramic view of the development of world philosophy as a whole is accessible, and it has become possible to understand that any constructions of the human mind that have arisen in a particular cultural field of experience cannot be regarded as exemplary and absolute. The researchers of Asian philosophies concentrate mostly on studying the texts of individual thinkers. As a rule, they do not set themselves the task of examining these texts from the point of view of intercultural interactions and transformations of significant ideas and concepts in various cultural and historical contexts, defining the direction and mechanisms of cultural borrowing, as well as revealing new approaches and growth points. To achieve these goals, the research should focus at the problem of the self-determination and development of philosophy as a separate science in non-Western cultures, which are based on intellectual traditions with different origin than Greek and Judeo-Christian traditions. This article deals with the consideration of some topics that elucidate the features of the development of philosophical science in Japan, including the emergence of the concept of “philosophy” in this country, the definition of its subject, the formation of philosophical terminology, and various interpretations of what the term “Japanese philosophy” means. The author pays special attention to the characteristic of the main periods of progress of Japanese philosophical thought. In the conclusion, the author argues that the most important characteristic feature of the Japanese philosophy is its involvement in intercultural dialogue throughout its history.
Feminist perspective in Foreign Policy – A way to women’s visibility and participation in public sphere
Authors: Rao Girija
Published: December 2018

In this paper it is intended to
express, articulate and analyze the role of feminist perspective in foreign
policy and how can it influence the foreign policies of nations, or can it
unravel the masculinity and patriarchy that is part and parcel of International
Relations, what measures are to be taken by nations to decrease the gender
gaps, and how exactly can this help nations achieve gender equality and make
women’s visibility and participation in public spaces a reality.

International Relation is a profound area that
establishes the relations among different nations and foreign policies reflect
a nation’s perspective towards others. Foreign policies determine the how and
why of diplomacy, wars, friendly relations etc. etc., However while doing so
nations have always shown a male oriented approach and the role of women either
in diplomatic positions or in war fields or in peace keeping or senior
positions in external affairs has been undermined worldwide. Feminist perspective
in foreign policy tries to explain the relationship between men and women in
International Politics and the gender roles that are designated among them. It
also tries to explain the socio-politico-economic policies the nations
implement, measures taken to eradicate the gender gaps that exists in this
field and how women’s equal participation in social production can bring about
a change in the political structure
KPAI Minta Guru yang Aniaya Muridnya di Pangkal Pinang Dievaluasi ditinjau dari Teori Actus Humanus
Authors: MANAJEMEN DIYAH FEBRI ASTUTI
Published: December 2018

Dalam kehidupan sehari- hari, di sekolah, masyarakat, di keluarga penganiyaan dapat terjadi. Di tempat sekolah dalam pendidikan yang menjadi tempat menuntut ilmu untuk para murid, justru terjadi tindakan penaniayaan di dalam dunia pendidkan. Berdasarkan kasus tersebut dipicu hal sepele, karena korban dianggap kurang ajar dengan sengaja memangil nama guru tersebut tanpa menggunakan kata “Pak”. Sehingga guru tersebut melakukan penganiayaan berat, karena tidak sekedar ditampar, tetapi siswa pun dibenturkan kepalanya ke diding. Sehingga korban mengalami sakit kepala. Penganiayaan banyak terjadi di kalangan dunia pendidikan dan akan berdampak buruk pada dunia pendidikan. Sebaiknya guru tersebut sebelum melakukan tindakannya harus dipikirkan terlebih dulu.
PEMBUNUHAN KELUARGA DIBEKASI DITINJAU DARI SUDUT PANDANG HATI NURANI SESAT
Authors: MANAJEMEN ILMA YUNITA NURDIANTI
Published: December 2018

Pembunuhan adalah suatu hal yang sangat tercela dan sangat tidak baik dan selain itu hal tersebut sangatlah tercela dan tidak terpuji .baik dalam kehidupan atau agama dan haltersebutsangat melanggar aturan pemerintah atau negara dengan hal ini sebagai orang yang mempunyai iman dan takwa maka dalam hal ini kita harus menhindari dan menjauhi larangan yang tidak baik dan terjela untuk supaya mempunyai ketentraman hati yang baik dan bersih .namun dalam hal ini etikamoral manusia sangat lemah.dan disini peran keluar dan masyarakatnsekitarsangat terkait dengan mengatasi terjadinya hal yang tidak bermoral .tujuan penelitian atau pembahasan ini adalah mengajak masyarakat tidak tercerumus dalam hal yang tidak baik dan menyimpang dan selain untuk saling berpikir yang positif . Metode penelitian atau pembahasan dalam hal ini adalah tentang pengamatan dan informasi tentang mengatatasi etika moral yang tidak baik dan mempunyai sifat yang positif dan tidak menyimpang dari perilaku yang tidak baik dan selain itu dapat mngimbangi dan menyadari bahawa pembunuhan dapat mrusak hal –hal yang berpengaruh pada pikiran dan hati yang sedang tidak baik dan merusak akal pikiran sseorang dan menimbulkan efek –efeek yang tidak terpuji. Masalah pembunuhan ini sangat tidak baik dan tercela .untuk mengatasi hal ini kita harus mendekatkan diri pada tuhan dan berpikir positif dan menyelesaikan masalah tidak dengan cara kotor dan menyimpng akan merugikan diri sendiri dan di sekitar anda .
Conceptual and Empirical Roots of Cultural Additivity
Authors: Ho Tung Manh
Published: December 2018

This essay seeks to explore the conceptual and empirical roots of the concept “cultural additivity” through the framework of ontological and epistemological divides of concepts and measurement put forth by Goertz and Mahoney (2012).
Ingin Bergantinya Pancasila
Authors: Wibowo Yusuf Eko
Published: December 2018

Akhir-akhir ini banyak sekali kasus-kasus yang berhubungan dengan ideologi negara, mulai dari pelecehan lambang negara dan lain sebagainya. Hal ini sangat menghawatirkan bagi bangsa indonesia. Dimana ideologi yang dulu susah payah dalam diperjuangkan kini tidak ada harganya bagi rakyatnya sendiri. Seperti kasus HTI yang ingin mengubah pancasila menjadi khilafah, dimana pancasila sudah menjadi dasar yang tidak bisa diganggu gugat karena pancasila adalah cerminan kehidupan bangsa Indonesia dalam menjalani kehidupan sehari-harinya. Selain itu kita juga harus menghormati para tokoh yang telah berjuang dalam membuat ideologi negara yang penuh dengan pertimbangan yang matang, yang sesuai dengan kondisi keadaan Indonesia saat masih dijajah yaitu gotong royong.
Keadilan Sosial Versi Soekarno dan Versi Masa Kini
Authors: Lorenza Agnes Nona
Published: December 2018

Dulu para tokoh BPUPKI dan juga PPKI telah bersusah payah dalam menyusun dan menetapkan dasar negara kita, yaitu Pancasila. Di dalam Pancasila tersebut terdapat lima sila. Sila yang akan saya bahas dalam paper ini adalah sila yang terakhir atau ke lima yaitu “Keadilan Sosial Bagi Seluruh Rakyat Indonesia”. Dalam sila tersebut sudah dikatakan bahwa keadilan yang ada di Indonesia itu menyeluruh bagi rakyat. Entah itu rakyat miskin, pejabat, atau bahkan presiden sekalipun seharusnya bisa sama rata dalam menikmati kemakmuran tanpa memandang status dan kedudukan yang dimiliki. Tapi apa yang terjadi dan kita temui pada masa sekarang ini? Apakah masih berlaku pernyataan tersebut?
“KASUS PENGEBOMAN SURABAYA 2018 DI TINJAU DARI ETIKA , TATAAN MORAL SUBJEKTIF DAN HUKUM”
Authors: luekito Vivi susanti , Dewantara Agustinus
Published: December 2018

Etika merupakan bagian dari filsafat dan kehidupan sehari - hari dalam kasus pengeboman di surabaya banyak orang menjadi korban dari kejadian pengeboman termasuk juga pelaku pengeboman itu sendiri kurangnya pengetahuan etika dalam diri pelaku yang membuat tatanan moral subjektif menjadi tidak berlaku . Pelaku adalah Jamaah Ansharut Saulah, Cabang Asia Tenggara Dari Organisasi ISIS. Pengetauan mengenai etika , tatanan moral subjektif dan hukum dapat di lihat dalam buku diktat Agustinus W Dewantara menjadi dasar sebagai dari teori teori tersebut.
”KASUS GUBENUR NONAKTIF NUR ALAM ATAS TINDAK PIDANA KORUPSI SEBAGAI BENTUK KEPEMIMPINAN YANG TIDAK MENYERTAKAN TINDAKAN ETIKA & KEUTAMAAN TANGGUNGJAWAB”
Authors: Merdekawati Karvina Anggi , Dewantara Agustinus
Published: December 2018

Paper bertujuan untuk menilai kasus gubenur nonaktif Nur Alam atas tindak pidana korupsi dilihat dari teori tindakan manusia dan keutamaan tanggungjawab. Reaserch ini didasarkan oleh perkembangan berita Nur Alam dalam situs berita online www.cnnindonesia.com & nasional.kompas.com , serta teori tindakan etis manusia dan keutamaan tanggung jawab yang berumber dari buku Filsafat Moral Pergumulan Etis Keseharian Hidup Manusia yang ditulis oleh Dewantara, A. (2017). Hasil analisis paper ini adalah kasus korupsi Nur Alam melanggar teori tindakan etika manusia & teori keutamaan tanggungjawab.
STUDI KASUS BULLYING SMAN 1 SEMARANG DITINJAU DARI TEORI TINDAKAN MANUSIA DAN TATANAN MORAL SUBJEKTIF
Authors: Krisshania  , Dewantara Agustinus
Published: December 2018

Tujuan penelitian ini adalah untuk membahas mengenai kasus pembullyan yang sangat marak di berbagai kalangan masyarakat terlebih untuk anak-anak muda yang ditinjau dari tindakan manusia, tatanan moral subjektif, dan tatanan moral objektif. Tindakan manusia adalah suatu keputusan yang dikehendaki manusia itu sendiri. Tatanan moral subjektif adalah dinamisme penilaian baik buruknya suatu tindakan yang dilakukan manusia. Tatanan moral objektif adalah tatanan moral yang dinilai dari konsekuensi atau hukum yang mengikatnya.
RELEVANSI KASUS PENISTAAN AGAMA DENGAN TEORI NEGARA DEMOKRASI
Authors: F Shylvia Lisdiana Ayu , Dewantara Agustinus
Published: December 2018

Demokrasi merujuk pada konsep kehidupan negara atau masyarakat. Demokrasi sangat diperlukan dalam menjalankan suatu negara. Demokrasi merupakan salah satu sistem politik. Politik adalah sistem atau tatanan hidup bersama yang ideal. Tetapi, jika diperhatikan dengan baik, paham pemerintahan demokrasi dalam filsafat Aristoteles masuk dalam bilangan bentuk negara tidak ideal. Demokrasi Indonesia juga erat hubungannya dengan nada dasar rasa religiositas. Seperti halnya diskusi ini mengambil contoh dari kasus penistaan agama yang pada saat itu terjadi di Kota Medan. Setelah kasus ini berlarut selama dua tahun, akhirnya Pengadilan Negeri Medan Sumatera Utara menjatuhkan vonis untuk Meiliana yang diduga pelaku penistaan agama. Harapannya masyarakat dapat hidup berdampingan dengan baik.
SEBAR HOAX PENCULIKAN ANAK DIRIAU
Authors: Julpinus
Published: December 2018

Sebar kebohongan(Hoax) adalah pelajaran bagi masyarakat agar pengguna media soasial dengan memberikan imformasi agar bijak dan selalu mengecek beneran. Pelaku penyebar hoax ini dijerat dengan pasal 45 A ayat 1 UU nomor 19 tahun 2016 tentang perubahan atas UU nomor 11 tahun 2028 tentang dan transaksi elektronik (ITE), ancaman 6 tahun penjara dan denda Rp 1 miliar. Yaitu juga yang mengandung unsure pornografi,isu sara, berita bohong, ujuaran kebencian yang sudah diatur UU IET. Dimana hukum manusiawi memiliki ikatan yang apabila dapat diverisifikasi oleh akal budi manusia dan haruslah dilihat dari hukum abadi, pada intinya adalah yang dipersoalkan sebar Hoax penculikan anak di Riau disini di tinjau dari Actus Humanus atau orangnya dan haknya, melainkan juga persoalannya pelecehan Hoax tersebut
KASUS PENGATURAN SKOR SEPAK BOLA INDONESIA , PENJUDI MENYOGOK MANAJER HINGGA PEMAIN DITINJAU DARI TATANAN MORAL SUBJEKTIF DAN OBJEKTIF
Authors: mukti sasono p
Published: December 2018

ABSTRAKDalam sebuah kehidupan kita pati mengenal tatantan moral yang mana yang baik dan yang mana yang buruk karena tatanan moral itu terbentuk setiap manusia di takdirkan hidup di dunia di mana tatanan moral itu akan selalu mencerminkan setiap diri manusia . kita mengenal tatanan moral sujektif dan tatanan moral objektif di mana tatanan moral tersebut saling berkaitan satu sama lain dalam kehidupan manusia karena tatanan moral tersebut mengatur tentang aklah manusia dan sanksi sankiyang di berikan ketika manusia melanggarnya . dari kasus tersebut dapat di simpulkan bahwa mafia mafia judi bola tersebut tidak memiliki tatanan moral yang baik karena hanya mementinkan kebutuhan pribandinya . dan pssi selaku pelindung organisasi justru ikut menjadi mafia mafia bola di Indonesia ini lah yang mencermin kan kualias olah raga di Indonesia khususnya sepak bola . pantas saja dari semua ajang keikut sertaan Indonesia dalam kanca inrernasiona dan regional selalu kalah karena para memainya sudah lagi tidak menunjukan kualitanya sebagi pemain yang hebat di segala kompetisi
Reexamining the effect of gustatory disgust on moral judgment: A multi-lab direct replication of Eskine, Kacinik, and Prinz (2011)
Authors: Ghelfi Eric , Christopherson Cody D , Urry Heather L. , Lenne Richie L , Legate Nicole , Fischer Mary Ann , Wagemans Fieke Maria Antoinet , Wiggins Bradford Jay , Barrett Tamara , Bornstein Michelle , de Haan Bianca , Guberman Joshua B. , Issa Nada , Kim Joan , Na Elim , O'Brien Justin , Paulk Aidan , Peck Tayler , Sashihara Marissa , Sheelar Karen , Song Justin , Steinberg Hannah , Sullivan Dasan
Published: December 2018

Eskine, Kacinik, and Prinz’s (2011) influential experiment demonstrated that gustatory disgust triggers a heightened sense of moral wrongness. We report a large-scale multi-site direct replication of this study conducted by participants in the Collaborative Replications and Education Project. Participants in each sample were randomly assigned to one of three beverage conditions: bitter/disgusting, control, or sweet. Then, participants made a series of judgments indicating the moral wrongness of the behavior depicted in each of six vignettes. In the original study (N = 57), drinking the bitter beverage led to higher ratings of moral wrongness than drinking the control and sweet beverages; a beverage contrast was significant among conservative (N = 19) but not liberal (N = 25) participants. In this report, random effects meta-analyses across all participants (N = 1,137 in k = 11 studies), conservative participants (N = 142, k = 5), and liberal participants (N = 635, k = 9) revealed standardized effect sizes that were smaller than reported in the original study. Some were in the opposite of the predicted direction, all had 95% confidence intervals containing zero, and most were smaller than the effect size the original authors could meaningfully detect. In linear mixed-effects regressions, drinking the bitter beverage led to higher ratings of moral wrongness than drinking the control beverage but not the sweet beverage. Bayes Factor tests reveal greater relative support for the null hypothesis. The overall pattern provides little to no support for the theory that physical disgust via taste perception harshens judgments of moral wrongness.
Rejoinder: More Limitations of Bayesian Leave-One-Out Cross-Validation
Authors: Gronau Quentin Frederik , Wagenmakers Eric-Jan
Published: December 2018

We recently discussed several limitations of Bayesian leave-one-out cross-validation (LOO) for model selection. Our contribution attracted three thought-provoking commentaries. In this rejoinder, we address each of the commentaries and identify several additional limitations of LOO-based methods such as Bayesian stacking. We focus on differences between LOO-based methods versus approaches that consistently use Bayes' rule for both parameter estimation and model comparison. We conclude that LOO-based methods do not align satisfactorily with the epistemic goal of mathematical psychology.
Familicide: A Systematic Literature Review
Authors: Karlsson Linda C. , Antfolk Jan , Putkonen Hanna , Amon Sabine , da Silva Guerreiro João , de Vogel Vivienne , Flynn Sandra , Weizmann-Henelius Ghitta
Published: December 2018

Familicides have received relatively little attention in previous research and mostly appear as a byproduct in studies with broader objectives. Here, we reviewed 67 studies from 18 countries, published between 1980 and 2017, that report on familicides in which an offender killed or attempted to kill their current or former spouse/intimate partner and one or more of their biological or stepchildren. Studies were identified by a systematical literature search in PubMed, PsycINFO, and Google Scholar. Only eight studies had the specific aim of investigating familicide, while the remaining studies investigated broader phenomena (e.g., homicide-suicide) but reported on a subsample of familicide cases. We retrieved data concerning the offenders’ gender, age, and background, as well as information regarding victims and their relationship to the offender. We also retrieved contextual factors and characteristics of the offence, such as modus operandi, offence location, possible premeditation, and whether or not the offender had died by suicide in connection to the offence. Furthermore, we coded methodological aspects of the studies, such as data collection coverage and sources of information. Familicides were almost exclusively committed by men and about half of the familicide cases led to the subsequent suicide of the offender. Mental health problems, relationship problems, and financial difficulties were prevalent. Because few studies reported population base rates of the investigated characteristics, it is difficult to draw conclusions about risk factors for familicide. Future research should further investigate typologies of familicide and examine risk factors associated with different types of familicides.
The ecology of competition: A theory of risk-reward environments in adaptive decision making
Authors: Pleskac Timothy Joseph , Conradt Larissa , Leuker Christina , Hertwig Ralph
Published: December 2018

In many choice environments, risks and rewards---or probabilities and payoffs---seem tightly coupled such that high payoffs only occur with low probabilities. An adaptive mind can exploit this association by, for instance, using a potential reward's size to infer the probability of obtaining it. However, a mind can only adapt to and exploit an environmental structure if it is ecologically reliable, that is if it is frequent and recurrent. We develop the competitive risk--reward ecology theory (CET) that establishes how the ecology of competition can make the association of high rewards with low probabilities ubiquitous. This association occurs because of what is known as the ideal free distribution (IFD) principle. The IFD states that competitors in a landscape of resource patches distribute themselves proportionally to the gross total amount of resources in the patches. CET shows how this principle implies a risk--reward structure: an inverse relationship between probabilities and payoffs. It also identifies boundary conditions for the risk--reward structure, including heterogeneity of resources, computational limits of competitors, and scarcity of resources. Finally, a set of empirical studies (N = 1,255) demonstrate that people’s beliefs map onto properties predicted by CET, and change as a function of the environment. In sum, grounding people's inferences in CET demonstrates how the behaviors of a boundedly rational mind can be better predicted once accounts of the mind and the environment are fused.
When National Unity Governments are neither National, United, nor Governments: The Case of Tunisia
Authors: Kubinec Robert , Grewal Sharan
Published: December 2018

Is power-sharing an effective way for endangered transitional democracies to reduce political tensions and improve government performance? We provide one of the first quantitative tests of this question in Tunisia, the Arab Spring's only success story. We argue that power-sharing may reduce polarization for a limited time, but at the cost of undermining democratic institutions. To measure polarization, we examine all rollcall votes from Tunisia's first and second post-transition parliaments. We employ a time-varying ideal point model and examine whether power-sharing agreements led to convergence in political parties' ideal points. Our analysis reveals that Tunisia's national unity government in 2015 temporarily moderated political tensions and allowed for parliamentary activity to resume. However, despite a broadening of the coalition in mid-2016, polarization reemerged and crucial legislation stalled. Moreover, longitudinal survey data suggest that the failure of power-sharing in Tunisia contributed to disillusionment with political parties, parliament, and democracy.
X-Ray Fluorescence Determination of Trace Elements in Vitamin-Mineral Complexes and Medicinal Herbs Using Chemically Modified Polyurethane Foam Sorbents
Authors: Chaplenko Alexander , Monogarova Oksana , Oskolok Kirill
Published: December 2018

In this paper we proposed the method of X-ray fluorescence (XRF) determination of some essential trace elements in medicinal herbs and vitamin-mineral complexes at the level of 100-101 mg/ml. To increase sensitivity and selectivity of the determination we simple and effective approach based on the extraction of metal ions from aqueous solutions with chemically modified polyurethane foam sorbents followed by direct XRF analysis. The conditions of sorption preconcentration of Co(II), Ni(II) and Zn(II) ions with modified sorbents were optimized. The proposed approach is used for the determination of trace elements in several kinds of medicinal herbs (coltsfoot leaves, nettle leaves and yarrow herb) and vitamin-mineral complexes («Alfavit», «Vitrum» and «Multi-tabs»).
Spectrophotometric Determination of Chlordiazepoxide in Pharmaceutical Formulations via Oxidative Coupling Reaction with Phenothiazine
Authors: J. Ahmed Mariam , Abdullah Hind H.
Published: December 2018

Abstract

A sensitive, precise and reliable indirect spectrophotometric method for the determination of chlordiazepoxide (CDE) in pure and pharmaceutical dosage forms is described. The method is based on oxidative coupling reaction between amino group resulting from acidic decomposition of CDE with phenothiazine in the presence of sodium periodate to produce an intense green soluble dye that is stable and shows a maximum absorption at 602 nm. The calibration plot indicates that Beer’s law is obeyed over the concentration range of 0.1?50 µg/mL, with a molar absorptivity of 1×104 L/mol cm and correlation coefficient of 0.9994.All the conditions that affecting on the stability and sensitivity of the formed product were studied and optimized and the suggested method was effectively applied for the determination of CDE in commercial dosage forms.
Hepatitis C patient communication source and modality preferences in the direct-acting antiviral era
Authors: Beaulac Julie , Corace Kim , Balfour Louise , Kaluzienski Mark , Cooper Curtis
Published: December 2018

Background: Although hepatitis C virus (HCV) treatment has improved dramatically, decision making related to treatment continues to be complex and challenging. Little data exists regarding patient information needs and preferences in the direct-acting antiviral (DAA) era. Methods: We evaluated patient-perceived information needs and preferences when making HCV treatment decisions. A cross-sectional survey was conducted at two Ottawa-based sites: a hospital-located outpatient viral hepatitis clinic, and a community-based HCV patient support program. Results: One hundred and seventeen patients completed the survey: the mean age was 52.1 years (range 23 to 78), and 64% were male, 81.5% were White, 48.6% were on disability support or leave, and 60.3% had a high school education or less. Although traditional sources of health information (e.g., direct communication with health care providers) remain preferred by most, a range of preferences were reported including utilization of newer technologies (e.g., emails, text messages). The telephone was rated as the preferred method of contact for medication reminders, with daily or weekly communication reported as most helpful. White participants, those more highly educated, and those with a higher income all indicated a greater acceptability for e-mail and/or text message communication for medication and appointment reminders. Conclusions: There is no single preferred source or method of communicating with patients. These findings indicate that a tailored multi-pronged approach, including newer technologies, is more likely to effectively educate and communicate with the heterogeneous population of individuals living with HCV.
Fluidized-Bed Heat Treating Equipment
Authors: Gao Weimin , Kong Lingxue , Hodgson Peter
Published: December 2018

This article discusses the important characteristics of fluidized beds. The total space occupied by a fluidized bed can be divided into three zones: grid zone, main zone, and above-bed zone. The article discusses the various types of atmospheres of fluidized beds, such as oxidizing and decarburizing atmosphere; nitrocarburizing and nitriding atmosphere; carburizing and carbonitriding atmosphere; and chemical vapor deposition atmosphere. External resistance heating, external combustion heating, internal resistance heating, direct resistance heating, submerged combustion heating, and internal combustion heating can be used to achieve the heat input for a fluidized bed. The article also describes the operations, design considerations, and applications of fluidized-bed furnaces in heat treating. Thermochemical surface treatments, such as carburizing, carbonitriding, nitriding, and nitrocarburizing, are also discussed. Finally, the article reviews the principles and applications of fluidized-bed heat treatment.
Quench Factor Characterization of Quenchants for Hardening of Steel
Authors: Otero R.L.S. , Otero W.R. , Canale L.C.F. , Totten G.E.
Published: December 2018

Successful hardening depends on the hardenability of steel composition, the geometry of parts, the quenching system, and on the heat treating process used. This article provides a brief overview of the computation and use of quench factor analysis (QFA) to quantify as-quenched hardness for carbon and low-alloy steels. As a single-value parameter alternative to Grossmann H-values, QFA is a potential method to qualify a quenching medium or process or to effectively monitor variation of quench severity due to either the quenchant or the system. The article describes the procedures for experimentally determining the quench factors by using a type 304 austenitic stainless steel probe. Typical examples of the utilization of QFA for quenchant characterization are provided. The article also describes the methods for experimentally generating time-temperature-property curves.
Heat Treating of Boron Steels
Authors: Deva Anjana , Kumar Jha Bimal
Published: December 2018

This article provides a detailed discussion on the effect of boron in heat-treated steel and thermomechanically-simulated steel. It describes the boron hardenability mechanism and the effect of composition and heat treatment parameters on boron hardenability. The article examines the hardening behavior of unalloyed boron steel and low-alloyed boron steel in heat treatment experiments by varying the austenitizing temperatures and cooling conditions. It also discusses the applications of boron steels.