bluuebunny/crossref_metadata_2025 huggingface dataset:
Bio-potential of Aqueous Extract of Verbesina encelioides, Moringa oleifera, Cassia fistula against Meloidogyne incognita
Authors: Apexa Pareek , Arvind Gaur , Payal Lodha
Published: September 2021

Background: The Meloidogyne incognita is the most destructive pathogen and causes loss of yield of various economically important plants of various families. It is polyphagous in behaviour and has a high reproductive rate, these parameters are a hurdle in management of it. Various chemicals are used to control nematode worldwide that are very expensive and highly toxic to the environment and human beings. For ecologically safe method, three plants i.e. Verbesina encelioides, Moringa oleifera, Cassia fistula and their various parts such as leaf, stem and flower’s cold aqueous extracts were tried in vitro to test their nematicidal activity. Methods: Cold aqueous extracts (10% w/v) of each plant material were prepared by mixing 10 g of each plant material in 100 ml of distilled water and kept aside for 48 hours. To estimate inhibition of egg hatching and mortality rate of second stage juveniles of Meloidogyne incognita, eggs and juveniles were exposed for 24, 48 and 72 hours in different concentrations (20 ppm to 200 ppm) of plant extracts. Result: All three tested plant extracts showed promising nematicidal activity against Meloidogyne incognita and the leaf extract of Moringa oleifera prevents the hatching of eggs. Inhibition of larval hatching from egg and nematode mortality rate were strongly influenced by concentration of extract, plant species and duration of exposure.
The Pedagogy of Rehabilitation Counseling: Perceptions of Rehabilitation Educators
Authors: Sprong Matthew E. , Brinck Emily A. , Iwanaga Kanako , Jones Jewel L. , Schultz Jared C.
Published: September 2021

The purpose of this study was to incorporate Bloom’s cognitive levels (Remembering/Knowledge, Understanding/Comprehension, Applying/Application, Evaluating, and Creating/Synthesis) of understanding for rehabilitation counselor training programs. Forty rehabilitation counselor educators completed an online survey rating how important, how confident, and how frequently each participant incorporated the six learning domains of Bloom’s taxonomy within the classroom. The results indicate that rehabilitation counseling educators stated that they felt confident and that it is important to implement all the learning domains of Bloom’s taxonomy. Rehabilitation counseling educators indicated that application learning domain has the most impact on student learning. This study also provides implications and future directions to help discussion among rehabilitation counselor educators.
Kommunikative Strategien zur Bewältigung von verbalen Tabus in ZeitzeugInnen-Interviews mit Verfolgten des Nationalsozialismus
Authors: Byelozyorova Olena
Published: September 2021

Der vorliegende Beitrag widmet sich den verbalen Tabus sowie den kommunikativen Strategien derer Bewältigung in den lebensgeschichtlichen Interviews mit den NS-ZeitzeugInnen. Die verbalen Tabus werden als Konzepte definiert, die keine explizite Verbalisierung im Diskurs dulden. Die Forschung hat ergeben, dass es grundsätzlich um zwei Tabu-Cluster geht. Zum einen handelt es sich um die traumatische Erfahrung der Verfolgung, die durch die kommunikative Strategie des Verschweigens und die der Euphemisierung bewältigt wird. Zum anderen geht es um den expliziten Ausdruck von negativen Emotionen – solche Tabus werden durch die kommunikative Strategie des Gesichtswahrens aufgefangen. Diese Strategien werden besonders effizient durch den Sprechakt der Andeutung realisiert, der ein diskursiv-sprachliches Zusammenwirken von Sprecher/in und Hörer/in zur Konstruktion der intendierten impliziten Proposition darstellt.
Utilização de Tecnologia da Informação por Micro e Pequenas Empresas:
Authors: Lavelli Alexander Ferreira , Lima Paulo Fernando , Piratelli Claudio Luís , Escrivão Filho Edmundo , Mazzali Leonel , Costa Vera Mariza Henriques de Miranda
Published: September 2021

Este artigo tem por objetivo caracterizar a utilização de Tecnologia da Informação (TI) para a gestão empresarial de Micro e Pequenas Empresas (MPEs) do setor de cerâmica artística e de decoração, localizado em município do estado de São Paulo. Trata-se de pesquisa exploratória-descritiva, aplicada, com abordagem qualitativa, desenvolvida por meio de uma pesquisa de campo, apoiada em pesquisa bibliográfica. O levantamento de campo foi realizado por meio de questionário e entrevistas com empresários e de depoimentos de agentes conhecedores do setor. Como resultado, pôde-se identificar baixo nível de utilização dos recursos de TI para a gestão empresarial: as MPEs, quando os utilizam, não o fazem estrategicamente. As dificuldades enfrentadas: na delimitação do universo de pesquisa, composto por empresas de cerâmica artística e de decoração, em município do interior do estado de São Paulo e na identificação de MPEs presentes nesse universo propiciaram resultados adicionais, de caráter metodológico, relativos a estratégias para localização de listagem e acesso a MPEs.
Determinan Pola Konsumsi Makanan Berisiko Pada Ibu di Kecamatan Mataram dan Gunungsari, Nusa Tenggara Barat
Authors: Wadhani Luh Putu Prema , Ratnaningsih Nani
Published: September 2021

Latar Belakang: Permasalahan konsumsi pangan yang tidak sehat saat ini menjadi prioritas utama yang perlu diperhatikan. Kemajuan dan perkembangan teknologi saat ini memberikan dampak pada perubahan pola konsumsi pada masyarakat perkotaan maupun pedesaan. Konsumsi pangan yang terjadi pada setiap indivdu dipengaruhi oleh berbagai faktor baik secara internal maupun eksternal. Tujuan: Penelitian ini bertujuan untuk mengetahui profil dan faktor determinan pola konsumsi makanan berisiko pada ibu Metode: Penelitian ini merupakan penelitian asosiatif dengan pendapatan survey pada bulan Januari - februari 2020. Sampel dalam penelitian ini yaitu ibu yang berada di Kecamatan gunungsari dan Mataram, Nusa Tenggara Barat yang diambil dengan teknik proportional random sampling sebanyak 110 sampel. Pengumpulan data determinan pola konsumsi makanan berisiko yang terdiri dari usia, pekerjaan, pendapatan, pendidikan dan pengetahuan dikumpulakan dengan menggunakan kuesioner dan data pola konsumsi makanan berisikoi dikumpulkan dengan menggunakan lembar food frequency (SQ-FFQ) selama 1 bulan terakhir. Data dalam penelitian ini dianalisis dengan menggunakan analisis regresi logistik.Hasil:  Sebanyak 75,5% ibu berusia 30 – 49 tahun, 69,9% ibu tidak bekerja, 61,8% dengan pendapatan < Rp. 1.500.000/bulan, 41,8% dengan pendidikan menengah, 77,3% ibu dengan pengetahuan konsumsi makanan berisiko yang baik dan 74,5% ibu dengan pola konsumsi makanan berisiko yang sering. Hasil analisis dalam penelitian ini menunjukkan bahwa tidak terdapat pengaruh pekerjaam (p=0,824), pendapatan (p=0,931) dan pendidikan (p=0,585) terhadap pola konsumsi makanan berisiko. Terdapat pengaruh usia (p=0,001) dan pengetahuan (p= 0,019) terhadap pola konsumsi makanan berisiko.Kesimpulan: Perlunya perhatian lebih terhadap faktor yang dapat menyebabkan tingginya pola konsumsi makanan berisiko sehingga meningkatkan konsumsi makanan yang sehat.
O PROJETO TRANSFORMAÇÃO EM ARTE
Authors: Fröhlich Sandro , Zambam Neuro José , Demenech Laiana Karolina
Published: September 2021

O objetivo deste artigo é analisar como o Projeto TransformAção em Arte, desenvolvido na Vila Popular, em Passo Fundo/RS – Brasil, na sua estratégia para a formação de pessoas, contribui efetivamente para a autonomia, a integração social e a sustentabilidade humana, social e ecológica, numa região com forte vulnerabilidade social. A estratégia metodológica contempla a exposição de aspectos relevantes coletados por meio de observações realizadas in loco por meio de visitas e outras informações acessadas de diversas fontes. O referencial teórico é a obra de Leonardo Boff. Os beneficiários, por meio da formação e participação, tornam-se agentes ativos de transformação.
CONSTITUCIONALISMO, HISTORIOGRAFIA E INTERCULTURALIDADE
Authors: Reis Rhuan Filipe Montenegro dos , Reis Marcelo Rodrigues dos
Published: September 2021

O presente trabalho analisa o fenômeno do constitucionalismo intercultural sob o prisma das diversas acepções de cultura bem como estabelece uma investigação histórica do fenômeno educacional como propulsor da promoção da diversidade. Nesse sentido, busca-se compreender a historicidade dos processos sociopolíticos e os fatores materiais que embasam as relações entre diversidade, educação, cultura e sustentabilidade na vigente sistemática constitucional. Analisa-se, em um primeiro momento, as ideias de educação, diversidade e democracia, considerado o enfrentamento dos abusos estatais contra coletividades e minorias. Por fim, tendo em vista o histórico das preocupações ambientais, discute-se a relação entre ethos, paideia e constitucionalismo.
DIREITO AO ESQUECIMENTO
Authors: Barros Willian Santana de , Rêgo Carolina Noura de Moraes
Published: September 2021

O presente artigo tem por finalidade perscrutar a existência de um direito da personalidade ao esquecimento, sua extensão e efeitos. O debate acerca da existência autônoma deste direito da personalidade perpassa por grandes divergências doutrinárias e jurisprudenciais, alcançando o julgamento de dois Recursos Especiais pelo STJ no ano de 2013 (REsp 1.334.097/RJ e REsp 1.335.153/RJ) e de um Recurso Extraordinário pelo STF em fevereiro de 2021 (RE 1010606/RJ, Relator Min. Dias Toffoli), dos quais se podem extrair importantes conclusões para a análise do tema. Por outro lado, a colisão entre o direito ao esquecimento e as liberdades públicas de expressão e informação, que tem se tornado mais frequente por força da difusão crescente da internet na atualidade, reclama do jurista uma detida análise acerca da extensão do direito ao esquecimento e das ferramentas disponíveis ou a serem desenvolvidas para que a tutela da personalidade possa ser garantida sem prejuízo dos direitos fundamentais de expressar-se, informar e ser informado. Nesta tarefa, não nos abstivemos de fazer uma breve incursão sobre o Marco Civil da Internet (Lei n. 12.965/2014) e a Lei Geral de Proteção de Dados Pessoais – LGPD (Lei n. 13.709/2018).
Clinically Translatable Approaches of Inhibiting TGF-β to Target Cancer Stem Cells in TNBC
Authors: Sulaiman Andrew , McGarry Sarah , Chilumula Sai Charan , Vinod Vishak , Kandunuri Rohith
Published: September 2021

Triple-negative breast cancer (TNBC) is a subtype of breast cancer that disproportionally accounts for the majority of breast cancer-related deaths due to the lack of specific targets for effective treatments. In this review, we highlight the complexity of the transforming growth factor-beta family (TGF-β) pathway and discuss how the dysregulation of the TGF-β pathway promotes oncogenic attributes in TNBC which negatively affects patient prognosis. Moreover, we discuss recent findings highlighting TGF-β inhibition as a potent method to target mesenchymal (CD44+/CD24-) and epithelial (ALDHhigh) cancer stem cell (CSC) populations. CSCs are associated with tumorigenesis, metastasis, relapse, resistance, and diminished patient prognosis; however, due to differential signal pathway enrichment and plasticity, these populations remain difficult to target and persist as a major barrier barring successful therapy. This review highlights the importance of TGF-β as a driver of chemoresistance, radioresistance and reduced patient prognosis in breast cancer and highlights novel treatment strategies which modulate TGF-β, impede cancer progression and reduce the rate of resistance generation via targeting the CSC populations in TNBC and thus reducing tumorigenicity. Potential TGF-β inhibitors targeting based on clinical trials are summarized for further investigation which may lead to the development of novel therapies to improve TNBC patient prognosis.
A High Resolution Spatiotemporal Fine Particulate Matter Exposure Assessment Model for the Contiguous United States
Authors: Brokamp Cole
Published: September 2021

Currently available nationwide prediction models for fine particulate matter (PM2.5) lack prediction confidence intervals and usually do not describe cross validated (CV) model performance at different spatiotemporal resolutions and extents. We used 41 different spatiotemporal predictors, including data on land use, meteorology, aerosol optical density, emissions, wildfires, population, traffic, and spatiotemporal indicators to train a machine learning model to predict daily averages of PM2.5 concentrations at 0.75 sq km resolution across the contiguous United States from 2000 through 2020. We utilized a generalized random forest model that allowed us to generate asymptotically-valid prediction confidence intervals and took advantage of its usefulness as an ensemble learner to quickly and cheaply characterize leave-one-location-out (LOLO) CV model performance for different temporal resolutions and geographic regions. Using a variable importance metric, we selected 8 predictors that were able to accurately predict daily PM2.5, with an overall LOLO CV median absolute error (MAE) of 1.20 μgm3, an R2 of 0.84, and confidence interval coverage fraction of 95%. When considering aggregated temporal windows, the model achieved LOLO CV MAEs of 0.99, 0.76, 0.63, and 0.60 μgm3 for weekly, monthly, annual, and all-time exposure assessments, respectively. We further describe the model’s CV performance at different geographic regions in the United States, finding that it performs worse in the Western half of the country where there are less monitors. The code and data used to create this model are publicly available and we have developed software packages to be used for exposure assessment. This accurate exposure assessment model will be useful for epidemiologists seeking to study the health effects of PM2.5 across the continential United States, while possibly considering exposure estimation accuracy and uncertainty specific to the the spatiotemporal resolution and extent of their study design and population.
Role of Extracellular Vesicles in Cell Death and Inflammation
Authors: Sanwlani Rahul , Gangoda Lahiru
Published: September 2021

Extracellular vesicles (EVs) have been identified as novel mediators of intercellular communication. They work via delivering the sequestered cargo to cells in close vicinity as well as distant sites in the body, regulating pathophysiological processes. Cell death and inflammation are biologically crucial processes in both normal physiology and pathology. These processes are indistinguishably linked with their effectors modulating the other process. For instance, during an unresolvable infection, the upregulation of specific immune mediators leads to inflammation causing cell death and tissue damage. EVs have gained considerable interest as mediators of both cell death and inflammation during conditions such as sepsis. This review summarizes the types of extracellular vesicles known to date and their roles in mediating immune responses leading to cell death and inflammation with specific focus on sepsis and lung inflammation.
Accuracy of Zero Inflated Generalized Poisson Exponentially Moving Average Control Chart
Authors: AFGANI L.M. JAMALUDDIN Al
Published: September 2021

The Zero-Inflated Generalized Poisson (ZIGP) distribution is a case-based distribution where the discrete data has a large number of zeros and an overdispersion occurs, i.e. the variance is greater than the mean value. The purpose of this study is to determine the Exponential Weight Moving Average (EWMA) control chart with the assumption that the data has a Zero-Inflated Generalized Poisson (ZIP) distribution. The results show that the ARL value of the ARL ZIGP EWMA control chart has better accuracy when compared to when using the ZIP EWMA control chart on ZIGP distributed data. This is indicated by the smaller ARL value compared to the ZIP EWMA control chart, namely when φ = 1.4, and φ = 0.6. So that the ARL ZIGP EWMA control chart has a fairly good accuracy in detecting out of control conditions for ZIGP distributed data. In addition, the modified ARL shows the same values ​​before and after the modification for the underdispersion data and shows a larger or negative value for the overdispersion data. This can eliminate or reduce errors in analyzing the accuracy of the control chart.
Grouping Districts/Cities in Kalimantan Island Based on The People's Welfare Indicators Using Fuzzy C-Means and Subtractive Fuzzy C-Means Methods
Authors: Fitri Nur Annisa , Hayati Memi Nor , Goejantoro Rito
Published: September 2021

Cluster analysis has the aim of grouping several objects of observation based on the data found in the information to describe the objects and their relationships. The grouping method used in this research is the Fuzzy C-Means (FCM) and Subtractive Fuzzy C-Means (SFCM) methods. The two grouping methods were applied to the people's welfare indicator data in 42 regencies/cities on the island of Kalimantan. The purpose of this study was to obtain the results of grouping districts/cities on the island of Kalimantan based on indicators of people's welfare and to obtain the results of a comparison of the FCM and SFCM methods. Based on the results of the analysis, the FCM and SFCM methods yield the same conclusions, so that in this study the FCM and SFCM methods are both good to use in classifying districts/cities on the island of Kalimantan based on people's welfare indicators and produce an optimal cluster of two clusters, namely the first cluster consisting of 10 Regencies/Cities on the island of Kalimantan, while the second cluster consists of 32 districts/cities on the island of Borneo.
The Kumaraswamy Lindley Regression Model with Application on the Egyptian Stock Exchange
Authors: Abdelmoezz Samy , Mohamed Salah M.
Published: September 2021

We introduce and study the Kumaraswamy Lindely Distribution (KLD)  model, which has increasing, decreasing, upside-down bathtub and bathtub shaped hazard functions.. We perform a Monte Carlo simulation study to assess the finite sample behavior of the maximum likelihood estimates of the parameters. We define a new regression model based on the new distribution. The new regression was applied to data from the Egyptian stock exchange in the period of (2015-2019). Finally, we study some properties of regression Residual analysis The martingale residual, Deviance component residual.
IMPLEMENTASI KONSEP COMPACT CITY PADA BWK I KOTA SURAKARTA
Authors: Mazidaturrizka Wilda , Rahayu Paramita , Nurhadi Kuswanto
Published: September 2021

Compact city atau kota yang kompak merupakan suatu konsep untuk mengelola pertumbuhan kota agar lebih efisien dengan menerapkan pembangunan intensif dengan guna lahan campuran, sehingga dapat mereduksi perjalanan penduduk kawasan. Konsep compact city menjadi solusi untuk menjawab tantangan isu-isu pertumbuhan kota yang meluas secara horizontal, seperti kepadatan yang kurang merata, penyediaan sarana dasar yang kurang memadai, serta isu-isu terkait pergerakan penduduk. Isu-isu tersebut kemudian menjadi tantangan pada BWK I Kota Surakarta, sehingga penelitian ini ditujukan untuk mengukur potensi implementasi konsep compact city pada BWK I Kota Surakarta yang diharapkan dapat menjadi solusi dari isu-isu tersebut. Potensi implementasi compact city ini diukur dari variabel penggunaan lahan, pelayanan sarana dasar dan kepadatan kawasan dengan menggunakan pendekatan kuantitatif dengan skoring skala Guttman. Penggunaan lahan yang dapat mendukung potensi implementasi compact city adalah penggunaan lahan campuran. Pada BWK I Kota Surakarta, penggunaan lahannya cenderung tidak memenuhi kriteria campuran pada sebagian besar kawasan. Kemudian dari segi pelayanan dasar, pada konsep compact city harus dapat mencakup keseluruhan kawasan. Sedangkan, pada BWK I Kota Surakarta masih ada beberapa jenis sarana dasar yang cakupannya tidak memenuhi keseluruhan kawasan. Terakhir, untuk kepadatan kawasan, pada compact city harus memenuhi standar kepadatan tinggi. Sedangkan, BWK I Kota Surakarta secara keseluruhan belum dapat dikategorikan sebagai kepadatan tinggi. Maka dari itu, hasil keseluruhan potensi implementasi compact city pada BWK I Kota Surakarta bernilai 44% dari 100%, yang berarti belum menunjukkan potensi penerapan konsep compact city. Namun, tidak menutup kemungkinan bisa dilakukan implementasi compact city dikemudian hari, jika dilakukan beberapa penyesuaian pembangunan kota terhadap kriteria konsep compact city.
PERAN PEMETAAN POTENSI PEMANFAATAN RUANG BERBASIS SISTEM INFORMASI GEOGRAFIS DALAM PENYELENGGARAAN PELAYANAN PUBLIK KELURAHAN (STUDI KASUS: KELURAHAN SONDAKAN, KECAMATAN LAWEYAN, KOTA SURAKARTA)
Authors: Putri Rufia Andisetyana , Rini Erma Fitria , Rahayu Murtanti Jani , Astuti Winny , Rahayu Paramita , Mukaromah Hakimatul
Published: September 2021

Tampilan digital data pemanfaatan ruang berbasis sistem informasi geografis (SIG) memungkinkan peningkatan efisiensi proses penyimpanan, pembaharuan, dan akses ulang data. Hal ini mendukung optimalisasi tugas aparat kelurahan dalam menyelenggarakan pelayanan publik. Tujuan artikel ini adalah menemukenali peran pemetaan potensi pemanfaatan ruang kelurahan berbasis SIG dalam penyelenggaraan pelayanan publik kelurahan. Tujuan ini dicapai melalui 2 tahapan, yakni (1) pemetaan potensi pemanfaatan ruang kelurahan berbasis sistem informasi geografis, dan (2) analisis peran pemetaan potensi pemanfaatan ruang kelurahan berbasis SIG dalam penyelenggaraan pelayanan publik kelurahan. Metode penelitian adalah studi kasus, dengan teknik analisis spasial menggunakan software ArcGIS, serta teknik deskriptif. Hasil analisis menunjukkan bahwa peta pemanfaatan ruang berbasis SIG memuat informasi spasial berupa lokasi, sebaran dan luasan tiap fungsi bangunan berperan dalam mendukung penyelenggaraan pelayanan publik aparat Kelurahan Sondakan, baik pada bidang pemerintahan, pembangunan dan ketentraman ketertiban, dan pemberdayaan masyarakat.
THE NEED OF ITEGRATION OF HEALTH ASPECTS IN SUSTAINABILITY BY URBAN-ARCHITECTURAL MULTICRITERIA ASSESSMENT TOOLS
Authors:   Wroclaw University of Science and Technology Faculty of Architecture Departament of Architecture and Visual Arts, Horn Paweł
Published: September 2021

Current situation of worsening of the health of individuals and societies requires response in architectural design. The article discusses possibilities for integration of health aspects and well-being factors in investment process in pursue of sustainability, by utilizing the advantages of the green building rating systems and evaluation tools which are already present in international and national practice. The aim of this article is to indicate the need for an integral approach in creating a built environment that allows for a healthy life in accordance with the location and current social and other problems. The author believes that the recognition of architectural objects as an integral part of complex urban structures is a necessary approach that determines the integration of the discussed aspects in design. The process should also include raising public awareness, focusing on better planning and design tools, and systems for collecting data and measuring health impacts. Integrating health parameters with already existing sustainable design procedures and standards is crucial. The core of the study was the observation and analysis of the already built housing environment, planned and designed according to the principles of sustainable development, in order to determine the degree of taking into account environmental elements and aspects of health on the object and urban scale.
CULTURAL LANDSCAPE AND TYPOLOGY OF THE KHARANAQ VILLAGE IN IRAN
Authors:   Department of Architecture University of Tehran, Tehran, Iran, Aghaeimeybodi Mojgan , Andaroodi Elham ,   Department of Architecture University of Tehran, Tehran, Iran
Published: September 2021

This article intends to analyse the historic village-castle of Kharanaq, which has been inhabited for over a thousand years in various historical periods. Different layers of habitation make Kharanaq’s residential context different from other castles or villages of Iran. This village-castle is fortified by high walls and is located at the edge of the Central Desert of Iran. This article focuses on identifying the interaction of the inhabitants with the desert environment of the village-castle through an analysis of its cultural landscape and the typology of its residential houses, as well as the current situation of its architecture and spaces.
Sexual Orientation and Gender Identity Data Collection at US Health Centers: Impact of City-Level Structural Stigma in 2018
Authors: Almazan Anthony N. , King Dana , Grasso Chris , Cahill Sean , Lattanner Micah , Hatzenbuehler Mark L. , Keuroghlian Alex S.
Published: September 2021

Objectives. To examine the relationship between city-level structural stigma pertaining to sexual orientation and gender identity (SOGI) and completeness of patient SOGI data collection at US federally qualified health centers (FQHCs).

Methods. We used the Human Rights Campaign’s Municipal Equality Index to quantify city-level structural stigma against sexual and gender minority people in 506 US cities across 49 states. We ascertained the completeness of SOGI data collection at FQHCs from the 2018 Uniform Data System, which describes FQHC patient demographics and service utilization. We included FQHCs in cities captured by the structural stigma index in multinomial generalized linear mixed models to examine the relationship between city-level structural stigma and SOGI data completeness.

Results. FQHCs in cities with more protective sexual orientation nondiscrimination policies reported more complete patient sexual orientation data (adjusted odds ratio [AOR] = 1.6; 95% confidence interval [CI] = 1.2, 2.1). This association was also found for gender identity nondiscrimination policies and gender identity data collection (AOR = 1.7; 95% CI = 1.3, 2.2).

Conclusions. Municipal sexual and gender minority nondiscrimination laws are associated with social and municipal environments that facilitate patient SOGI data collection.(Am J Public Health. 2021;111(11):2059–2063. https://doi.org/10.2105/AJPH.2021.306414 )
Comparison of Smoking Habits and Coffee Consumption In Adolescents Against Hemoglobin Levels In Mojoroto Kediri City
Authors: Purnadianti Mely , Ermawati Nita , Berlian Rere Nadhif
Published: September 2021

Cigarettes are processed tobacco using or without addictive substances. The increasing of hemoglobin in smokers due to the content of carbon monoxide causes hemolysis of erythrocytes that is stronger than oxygen, so that hemoglobin increases. In addition to smoking, the society's habit is about coffee consumption. Coffee is a beverage with high polyphenols. The decreasing of hemoglobin occurs when drinking too much coffee. It will reduce the absorption of iron and erythrocytes ability to deliver oxygen from the lungs to all tissues in the body, therefore the hemoglobin will decrease. One of the laboratory tests that is used to see hemoglobin levels in smokers and coffee consumers is the POCT method of hemoglobin examination. The purpose of this study was to analyze the comparison of the effect between smoking and coffee consumption on hemoglobin levels in adolescents on the streets of Mejenan Gang 3 Mojoroto Kediri. The method that is used in this research is comparative study and the sampling technique that is used purposive sampling with a sample size of 40 respondents. The results show that 10 adolescents (50%) had abnormal hemoglobin levels and 10 adolescents (50%) had normal hemoglobin levels. 5 teenagers (25%) had abnormal hemoglobin levels and 15 (75%) normal hemoglobin levels. Based on statistical tests, the results obtain p-value 0.423 and> 0.05. So it can be concluded that there is a moderate effect between cigarettes and coffee on hemoglobin levels in adolescents on Mejenan Street Gang 3 Mojoroto Kediri.
Comparison of Erythrocyte Index Values of Venous and Capillary Blood
Authors: Wahyuni Nining , Aliviameita Andika
Published: September 2021

Erythrocyte index is a laboratory examination in establishing the diagnosis of anemia including MCV, MCH, and MCHC obtained from the calculation of hemoglobin, hematocrit, and the number of erythrocytes. This study aims to determine differences in the value of the erythrocyte index in venous and capillary blood. This research is an experimental laboratory study, the sample was examined at the Ar-Rahmah Tulangan Clinic in Sidoarjo in March 2020. The examination method used in this study was automatic. Blood samples were taken from 30 patients so that a total of 60 blood samples (30 venous blood and 30 capillary blood). The results of the examination with the Mann Withney test showed a significant difference in the value of MCV (p = 0.001) and MCH (p = 0.001) and there was no difference in the value of MCHC (p = 0.251).
Pre-Toddler Development Examination Screening (KPSP) at Posyandu Jatikalang Village, Prambon District, Sidoarjo Regency
Authors: Mudlikah Siti , Putri Lidia Aditama
Published: September 2021

Delay in the development of children under five occurs around 10% in children aged <5 years. The purpose of community service activities is to carry out checks on child development and assess child development using the Pre-Screening Questionnaire for Child Development. The method uses interviews and observations. The study population is all mothers who have children under five, the sample is all children aged <5 years who come to the posyandu. The results show that the age period of children 3 - 72 months, the majority of children aged 15 months are 11 children (14%), 6 months of age are 10 children (12.9%), 30 months of age are 9 children (11.6%), age 3 month totaling 8 children (10.3%). While children with appropriate development are 65 children (83%), development children are doubting 12 children (15.4%) and children with deviant development are 1 child (1.3%). Thus children who have doubts and deviant developments need to do counseling and stimulation interventions to improve children's optimal developmental abilities.
The Relationship between Personal Hygiene Behavior with Vaginal Discharge in Young Women
Authors: Amalia Putri Arizki , Amelia Kusumawardhani Paramitha
Published: September 2021

Vaginal discharge is a sign of disturbance to the body, can be fisiological and pathological. One of factor is personal hygiene. Vaginal discharge incidence in psychology students at Universitas Muhammadiyah Sidoarjo higher (80%) than in Sidoarjo at 40%. This research is for determining the relationship between personal hygiene behavior with vaginal discharge. Designed used analytical with cross sectional approach. The instrument is questionnaire. Sampels are 23 in simple random sampling from 30 population. The result showed fisiological vaginal discharge more happens to good personal hygiene than not good. Test result P=0,026 < α(0,05), Ho is rejected. Conclusion there is a relationship between personal hygiene behavior with vaginal discharge. Vaginal discharge is a sign of disturbance to the body, can be fisiological and pathological. One of factor is personal hygiene. Vaginal discharge incidence in psychology students at Universitas Muhammadiyah Sidoarjo higher (80%) than in Sidoarjo at 40%. This research is for determining the relationship between personal hygiene behavior with vaginal discharge. Designed used analytical with cross sectional approach. The instrument is questionnaire. Sampels are 23 in simple random sampling from 30 population. The result showed fisiological vaginal discharge more happens to good personal hygiene than not good. Test result P=0,026 < α(0,05), Ho is rejected. Conclusion there is a relationship between personal hygiene behavior with vaginal discharge.
PENGARUH KOMBINASI PUPUK ORGANIK DAN PUPUK HAYATI TERHADAP PERTUMBUHAN, PRODUKSI DAN MUTU PEGAGAN
Authors: Widyastuti Rahma , Listyana Nurul Husniyati , Hartanto Erri Setyo
Published: September 2021

Gotu kola is one of the medicinal plants that has begun to be cultivated by the Indonesian people. It’s cultivation needs to follow the GAP to produce the qualified yield, including the use of fertilizers. Biofertilizers have been widely developed to reduce adverse effects of chemical fertilizers to the environment, thus an organic cultivation method can be an alternative. The aim of this study was to determine the effect of biofertilizer on growth and yield of gotu kola. This research was an experimental study with a completely randomized design (CRD) using 8 planting media treatments consisting of (a) Soil + manure + dolomite; (b) Soil manure + 1 g biofertilizer; (c) Soil + dolomite + 1g biofertilizer; (d) Soil + manure + 3 biofertilizer; (e) Soil + dolomite + 3 biofertilizer; (f) Soil + manure + 5 g biofertilizer; (g)  Soil + dolomite + 5 g  biofertilizer;  and  (h)  Soil +  3 g biofertilizer. Parameters observed were leaf area, stem length, number of leaves, number of tillers, fresh weight, dry weight and asiaticoside content. The results showed that combination treatment of biofertilizer (1 g) with dolomite (30 g) gives better effect in increasing the number of tillers and number of leaves, while the combination of biofertilizer (5 g) and dolomite (30 g) is the best for asiaticoside levels in gotu cola.
Cell surface and intracellular auxin signalling for H+-fluxes in root growth
Authors: Li Lanxin , Verstraeten Inge , Roosjen Mark , Takahashi Koji , Rodriguez Lesia , Merrin Jack , Chen Jian , Shabala Lana , Smet Wouter , Ren Hong , Vanneste Steffen , Shabala Sergey , De Rybel Bert , Weijers Dolf , Kinoshita Toshinori , Gray William M. , Friml Jiří
Published: September 2021

Growth regulation tailors plant development to its environment. A showcase is response to gravity, where shoots bend up and roots down1. This paradox is based on opposite effects of the phytohormone auxin, which promotes cell expansion in shoots, while inhibiting it in roots via a yet unknown cellular mechanism2. Here, by combining microfluidics, live imaging, genetic engineering and phospho-proteomics in Arabidopsis thaliana, we advance our understanding how auxin inhibits root growth. We show that auxin activates two distinct, antagonistically acting signalling pathways that converge on the rapid regulation of the apoplastic pH, a causative growth determinant. Cell surface-based TRANSMEMBRANE KINASE1 (TMK1) interacts with and mediates phosphorylation and activation of plasma membrane H+-ATPases for apoplast acidification, while intracellular canonical auxin signalling promotes net cellular H+-influx, causing apoplast alkalinisation. The simultaneous activation of these two counteracting mechanisms poises the root for a rapid, fine-tuned growth modulation while navigating complex soil environment.
HINRL4Rec: A Novel Integrated Heterogeneous Network Embedding with Reinforcement Learning for Recommendation
Authors: Vo Tham
Published: September 2021

Recent KG-oriented recommendation techniques mainly focus on the direct interaction between entities in the given KGs as the rich information sources for leveraging the quality of recommendation outputs. However, they are still hindered by the heterogeneity, type-varied entities and their relationships in knowledge graphs (KG) as the heterogeneous information networks (HIN). This limitation seems challenging to build up an effective approach for the KG-based recommendation system in both semantic path-based exploitation and heterogeneous information extraction. To meet these challenges, we proposed a novel integrated HIN embedding with reinforcement learning (RL)-based feature engineering for recommendation, called as: HINRL4Rec. First of all, we apply the combined textual meta-path-based embedding approach for learning multiple-rich-schematic representations of user/item and their associated entities. Then, these extracted multi-typed embeddings of user and item entities are fused into the unified embedding spaces during the KG embedding process. Finally, the unified representations of users and items are then used to facilitate the RL-based policy-driven searching process in the next steps for performing the recommendation task. Extensive experiments in real-world datasets demonstrate the effectiveness of our proposed model in comparing with recent state-of-the-art recommendation baselines.
SCUBE3 Downregulation Modulates Hepatocellular Carcinoma By Inhibiting CCNE1 Via TGFβ/PI3K/AKT/GSK3β Pathway
Authors: xu Pan , Luo Aoran , Xiong Chuan , Ren Hong , Liang Yan , Luo Qiang
Published: September 2021

Objectives: We aimed to verify the role of signal peptide-CUB-EGF-like domain-containing protein3 (SCUBE3) in the hepatocellular carcinoma (HCC) progression.Methods: The role·of SCUBE3 in HCC cell proliferation, apoptosis, and cell cycle in vitro were investigated using MTT assay, 5-ethynyl-2´-deoxyuridine assay (EDU), Celigo cell counting assay, Caspase3/7 activity assay, and flow cytometry. The effect of SCUBE3 on HCC cell proliferation in vivo was investigated by a xenograft tumor model in nude mice. The related mechanisms were further investigated.Results: SCUBE3 was upregulated in HCC tissues and cell lines. Knockdown of SCUBE3 inhibited proliferation, promoted apoptosis, and induced cell cycle arrest in HCC cell lines in vitro and vivo. Screening of cell cycle-related proteins revealed CCNL2, CDK6, CCNE1, and CCND1 exhibited a significantly different expression profile. We found that SCUBE3 may promote the proliferation of HCC cells by regulating CCNE1 expression. The pathway enrichment analysis showed that the TGFβ signaling pathway and the PI3K/AKT signaling pathway were significantly altered. Co-immunoprecipitation results showed that SCUBE3 binds to the TGFβRII receptor. SCUBE3 knockdown inhibited the PI3K/AKT signaling pathway and the phosphorylation of GSK3β to inhibit its kinase activity.Conclusions：SCUBE3 promotes HCC development by regulating CCNE1 via TGFβ/PI3K/AKT/GSK3βpathway. In addition, SCUBE3 may be a new molecular target for clinical diagnosis and treatment of HCC.
Realization of Ultrathin Waveguides by Elastic Metagratings
Authors: Hu Yabin , Zhang Yunhao , Su Guangyuan , Zhao Meiying , Li Bing , Liu Yongquan , Li Zheng
Published: September 2021

Guiding transports of classical waves has inspired a wealth of nontrivial physics and momentous applications in a wide range of fields. To date, a robust and compact way to guide energy flux travelling along an arbitrary, prescheduled trajectory in a uniform medium is still a fundamental challenge. Here we propose and experimentally realize a generic framework of ultrathin waveguides for full-angle wave trapping and routing. The metagrating-based waveguide can totally suppress all high-order parasitic diffractions to efficiently route guided elastic waves without leakage. Remarkably, the proposed waveguide protype works in a broad frequency range from 12 to 18 kHz and regardless of the incident angle. An analytical slab-waveguide model is further presented to predict and tailor the diffracted patterns in the metagrating-based waveguide. Compared with existing methods based on topological edge states or defected metamaterials, our meta-waveguide strategy exhibits absolute advantages in compact size, robust performance, and easy fabrication, which may provide a new design paradigm for vibration control in solids, wave steering in electromagnetics, acoustics and other waves.
TGF-β1 Regulates Smooth Muscle Cells Differentiation from Adipose-Derived Stem Cells via the Wnt/β-Catenin Pathway
Authors: Lv Xuling , Chen Hao , Zhang Zikai , Li Tian , Wei Qing , He Yucang , Wang Jingping , Li Liqun , Lin Ming
Published: September 2021

Background: Pelvic floor dysfunction (PFD) is a spectrum of disorders including stress urinary incontinence and pelvic organ prolapse. Transforming growth factor-β1 (TGF-β1) can induce mesenchymal stem cells (MSCs) to differentiate into smooth muscle cells (SMCs). SMCs derived from adipose-derived stem cells (ADSCs) can be used to repair damaged pelvic floor smooth muscle tissues, which is of great interest for clinical applications using stem cell therapy for PFD. The Wnt/β-catenin pathway acts as a decisive factor in the fate of stem cells.Methods and Results: In this study, we used medium containing TGF-β1, TGF-β1 inhibitor LY2109761, or Wnt/β-catenin inhibitor KYA1797K, to induce ADCSs to differentiate into SMCs in vitro to explore the influence of TGF-β1 on the myogenic differentiation of ADCSs via the Wnt/β-catenin pathway. Results: 1) TGF-β1 induces ADSC-derived SMCs to hyper-express the SMC markers including SMA-α, Desmin, Calponin, and SMMHC ; 2) TGF-β1 activates the Wnt/β-catenin signaling pathway in ADSCs. After blocking TGF-β1, the Wnt/β-catenin pathway and myogenic differentiation in cells were inhibited; 3) the Wnt/β-catenin pathway is involved in the differentiation of ADSCs into SMCs. After differentiation induction, the synchronized changes in the activation of Wnt/β-catenin signaling and the expression of SMC-specific proteins showed a trend of simultaneous changes, and after the inhibition of the Wnt pathway, the adult muscle differentiation was significantly inhibited.Conclusions: We established a simpler and more efficient method for inducing ADSCs to differentiate into SMCs using TGF-β1 and demonstrated that the Wnt/β-catenin signaling pathway is activated during this process.
Interval Data Aggregation Technology for Large Scale Decision Making
Authors: Chen Linxin , Chen Riqing , Lin Jian
Published: September 2021

In this paper, an improved multiple attribute decision making (MADM) method based on the proposed novel score function and accuracy function of interval-valued intuitionistic fuzzy numbers (IVIFNs) is proposed to aggregate large-scale data. The attribute values in the decision matrices provided by each decision-maker (DM), which are characterized by interval numbers. First, a transformation matrix is introduced to define the concepts of satisfactory set, un- satisfactory set and uncertainty set of alternatives. An approach is then developed for aggregating attribute values into IVIFNs, and we will obtain the collective evaluation of each alternative. Next, using the interval-valued intuitionistic fuzzy weighted averaging operator, the collective attribute values characterized by IVIFNs are aggregated to get the overall evaluation of alternatives. The score function and accuracy function are applied to calculate the score degree and the rank of each alternative. Finally, a large-scale example is given to verify the validity of the reported method.
Black carbon and dust alter the response of mountain snow
cover under climate change
Authors: REVEILLET Marion , Dumont Marie , Gascoin Simon , Lafaysse Matthieu , Nabat Pierre , Ribes Aurélien , Nheili Rafife , Tuzet François , Menegoz Martin , Morin Samuel , Picard Ghislain , Ginoux Paul
Published: September 2021

By darkening the snow surface, mineral dust and black carbon (BC) deposition enhances snowmelt and triggers numerous feedbacks. Assessments of their long-term impact at the regional scale are still largely missing despite the environmental and socio-economic implications of snow cover changes. Here we show, using numerical simulations, that dust and BC deposition has advanced snowmelt by 17 days on average in the French Alps and the Pyrenees over the 1979–2018 period, with major implications for water availability. We demonstrate that the decrease in BC deposition since the 1980s moderates the impact of current warming on snow cover decline. Hence, accounting for changes in light-absorbing particles deposition is required to improve the accuracy of snow cover reanalyses and climate projections, that are crucial for better understanding the past and future evolution of mountain social-ecological systems.
Enforced Home-working Under Lockdown and its Impact on Employee Wellbeing: A Cross-sectional Study
Authors: Platts Katharine , Breckon Jeff , Marshall Ellen
Published: September 2021

Background: The Covid-19 pandemic precipitated a shift in the working practices of millions of people. Nearly half the British workforce (47%) reported to be working at home under lockdown in April 2020. This study investigated the impact of enforced home-working under lockdown on employee wellbeing via markers of stress, burnout, depressive symptoms, and sleep. Moderating effects of factors including age, gender, number of dependants, mental health status and work status were examined alongside work-related factors including work-life conflict and leadership quality. Method: Cross-sectional data were collected over a 12-week period from May to August 2020 using an online survey. Job-related and wellbeing factors were measured using items from the COPSOQIII. Stress, burnout, somatic stress, cognitive stress, and sleep trouble were tested together using MANOVA and MANCOVA to identify mediating effects. T-tests and one-way ANOVA identified differences in overall stress. Pearson’s correlation coefficient assessed the moderating effects of work status. Regression trees identified groups with highest and lowest levels of stress and depressive symptoms. Results: 81% of respondents were working at home either full or part-time (n=623, 62% female). Detrimental health impacts of home-working during lockdown were most acutely experienced by those with existing mental health conditions regardless of age, gender, or work status, and were exacerbated by working regular overtime. In those without mental health conditions, predictors of stress and depressive symptoms were being female, under 45 years, home-working part-time and two dependants, though men reported greater levels of work-life conflict. Place and pattern of work had a greater impact on women. Lower leadership quality was a significant predictor of stress and burnout for both men and women, and, for employees aged >45 years, had significant impact on level of depressive symptoms experienced. Conclusions: Experience of home-working under lockdown varies amongst groups. Knowledge of these differences provide employers with tools to better manage employee wellbeing during periods of crisis. While personal factors are not controllable, the quality of leadership provided to employees, and the ‘place and pattern’ of work, can be actively managed to positive effect. Innovative flexible working practices will help to build greater workforce resilience.
Towards A Genetic Model Organism: An Efficient Method For Stable Genetic Transformation of Eschscholzia Californica (Ranunculales)
Authors: Lotz Dominik , Imani Jafargholi , Ehlers Katrin , Becker Annette
Published: September 2021

California poppy (Eschscholzia californica) is a member of the Ranunculales, the sister order to all other eudicots and as such in a phylogenetically highly informative position. Ranunculales are known for their diverse floral morphologies and biosynthesis of many pharmaceutically relevant alkaloids. E. californica it is widely used as model system to study the conservation of flower developmental control genes. However, within the Ranunculales, options for stable genetic manipulations are rare and genetic model systems are thus difficult to establish. Here, we present a method for the efficient and stable genetic transformation via Agrobacterium tumefaciens-mediated transformation, somatic embryo induction, and regeneration of E. californica. Further, we provide a rapid method for protoplast isolation and transformation. This allows the study of gene functions in a single-cell and full plant context to enable gene function analysis and modification of alkaloid biosynthesis pathways by e.g. genome editing techniques providing important genetic resources for the genetic model organism E. californica.