bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table S6 from Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk
Authors: Kimura Shunsuke , Park Chun Shik , Montefiori Lindsey E. , Iacobucci Ilaria , Pölönen Petri , Gao Qingsong , Arnold Elizabeth D. , Attarbaschi Andishe , Brown Anthony , Buldini Barbara , Caldwell Kenneth J. , Chang Yunchao , Chen Chelsey , Cheng Cheng , Cheng Zhongshan , Choi John , Conter Valentino , Crews Kristine R. , de Groot-Kruseman Hester A. , Deguchi Takao , Eguchi Mariko , Muhle Hannah E. , Elitzur Sarah , Escherich Gabriele , Freeman Burgess B. , Gu Zhaohui , Han Katie , Horibe Keizo , Imamura Toshihiko , Jeha Sima , Kato Motohiro , Chiew Kean H. , Khan Tanya , Kicinski Michal , Köhrer Stefan , Kornblau Steven M. , Kotecha Rishi S. , Li Chi-Kong , Liu Yen-Chun , Locatelli Franco , Luger Selina M. , Paietta Elisabeth M. , Manabe Atsushi , Marquart Hanne V. , Masetti Riccardo , Maybury Mellissa , Mazilier Pauline , Meijerink Jules P.P. , Mitchell Sharnise , Miyamura Takako , Moore Andrew S. , Oshima Koichi , Pawinska-Wasikowska Katarzyna , Pieters Rob , Prater Mollie S. , Pruett-Miller Shondra M. , Pui Ching-Hon , Qu Chunxu , Reiterova Michaela , Reyes Noemi , Roberts Kathryn G. , Rowe Jacob M. , Sato Atsushi , Schmiegelow Kjeld , Schrappe Martin , Shen Shuhong , Skoczeń Szymon , Spinelli Orietta , Stary Jan , Svaton Michael , Takagi Masatoshi , Takita Junko , Tang Yanjing , Teachey David T. , Thomas Paul G. , Tomizawa Daisuke , Trka Jan , Varotto Elena , Vincent Tiffaney L. , Yang Jun J. , Yeoh Allen E.J. , Zhou Yinmei , Zimmermann Martin , Inaba Hiroto , Mullighan Charles G.
Published: October 2024

Detected mutations by whole genome or RNA sequencing.
Supplementary Table S4 from Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk
Authors: Kimura Shunsuke , Park Chun Shik , Montefiori Lindsey E. , Iacobucci Ilaria , Pölönen Petri , Gao Qingsong , Arnold Elizabeth D. , Attarbaschi Andishe , Brown Anthony , Buldini Barbara , Caldwell Kenneth J. , Chang Yunchao , Chen Chelsey , Cheng Cheng , Cheng Zhongshan , Choi John , Conter Valentino , Crews Kristine R. , de Groot-Kruseman Hester A. , Deguchi Takao , Eguchi Mariko , Muhle Hannah E. , Elitzur Sarah , Escherich Gabriele , Freeman Burgess B. , Gu Zhaohui , Han Katie , Horibe Keizo , Imamura Toshihiko , Jeha Sima , Kato Motohiro , Chiew Kean H. , Khan Tanya , Kicinski Michal , Köhrer Stefan , Kornblau Steven M. , Kotecha Rishi S. , Li Chi-Kong , Liu Yen-Chun , Locatelli Franco , Luger Selina M. , Paietta Elisabeth M. , Manabe Atsushi , Marquart Hanne V. , Masetti Riccardo , Maybury Mellissa , Mazilier Pauline , Meijerink Jules P.P. , Mitchell Sharnise , Miyamura Takako , Moore Andrew S. , Oshima Koichi , Pawinska-Wasikowska Katarzyna , Pieters Rob , Prater Mollie S. , Pruett-Miller Shondra M. , Pui Ching-Hon , Qu Chunxu , Reiterova Michaela , Reyes Noemi , Roberts Kathryn G. , Rowe Jacob M. , Sato Atsushi , Schmiegelow Kjeld , Schrappe Martin , Shen Shuhong , Skoczeń Szymon , Spinelli Orietta , Stary Jan , Svaton Michael , Takagi Masatoshi , Takita Junko , Tang Yanjing , Teachey David T. , Thomas Paul G. , Tomizawa Daisuke , Trka Jan , Varotto Elena , Vincent Tiffaney L. , Yang Jun J. , Yeoh Allen E.J. , Zhou Yinmei , Zimmermann Martin , Inaba Hiroto , Mullighan Charles G.
Published: October 2024

Patient characteristics of 76 γδ T-ALL cases performed genomic analysis.
Supplementary Table S22 from Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk
Authors: Kimura Shunsuke , Park Chun Shik , Montefiori Lindsey E. , Iacobucci Ilaria , Pölönen Petri , Gao Qingsong , Arnold Elizabeth D. , Attarbaschi Andishe , Brown Anthony , Buldini Barbara , Caldwell Kenneth J. , Chang Yunchao , Chen Chelsey , Cheng Cheng , Cheng Zhongshan , Choi John , Conter Valentino , Crews Kristine R. , de Groot-Kruseman Hester A. , Deguchi Takao , Eguchi Mariko , Muhle Hannah E. , Elitzur Sarah , Escherich Gabriele , Freeman Burgess B. , Gu Zhaohui , Han Katie , Horibe Keizo , Imamura Toshihiko , Jeha Sima , Kato Motohiro , Chiew Kean H. , Khan Tanya , Kicinski Michal , Köhrer Stefan , Kornblau Steven M. , Kotecha Rishi S. , Li Chi-Kong , Liu Yen-Chun , Locatelli Franco , Luger Selina M. , Paietta Elisabeth M. , Manabe Atsushi , Marquart Hanne V. , Masetti Riccardo , Maybury Mellissa , Mazilier Pauline , Meijerink Jules P.P. , Mitchell Sharnise , Miyamura Takako , Moore Andrew S. , Oshima Koichi , Pawinska-Wasikowska Katarzyna , Pieters Rob , Prater Mollie S. , Pruett-Miller Shondra M. , Pui Ching-Hon , Qu Chunxu , Reiterova Michaela , Reyes Noemi , Roberts Kathryn G. , Rowe Jacob M. , Sato Atsushi , Schmiegelow Kjeld , Schrappe Martin , Shen Shuhong , Skoczeń Szymon , Spinelli Orietta , Stary Jan , Svaton Michael , Takagi Masatoshi , Takita Junko , Tang Yanjing , Teachey David T. , Thomas Paul G. , Tomizawa Daisuke , Trka Jan , Varotto Elena , Vincent Tiffaney L. , Yang Jun J. , Yeoh Allen E.J. , Zhou Yinmei , Zimmermann Martin , Inaba Hiroto , Mullighan Charles G.
Published: October 2024

The results of dose-response validation for 138 compounds.
Supplementary Table S2 from Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk
Authors: Kimura Shunsuke , Park Chun Shik , Montefiori Lindsey E. , Iacobucci Ilaria , Pölönen Petri , Gao Qingsong , Arnold Elizabeth D. , Attarbaschi Andishe , Brown Anthony , Buldini Barbara , Caldwell Kenneth J. , Chang Yunchao , Chen Chelsey , Cheng Cheng , Cheng Zhongshan , Choi John , Conter Valentino , Crews Kristine R. , de Groot-Kruseman Hester A. , Deguchi Takao , Eguchi Mariko , Muhle Hannah E. , Elitzur Sarah , Escherich Gabriele , Freeman Burgess B. , Gu Zhaohui , Han Katie , Horibe Keizo , Imamura Toshihiko , Jeha Sima , Kato Motohiro , Chiew Kean H. , Khan Tanya , Kicinski Michal , Köhrer Stefan , Kornblau Steven M. , Kotecha Rishi S. , Li Chi-Kong , Liu Yen-Chun , Locatelli Franco , Luger Selina M. , Paietta Elisabeth M. , Manabe Atsushi , Marquart Hanne V. , Masetti Riccardo , Maybury Mellissa , Mazilier Pauline , Meijerink Jules P.P. , Mitchell Sharnise , Miyamura Takako , Moore Andrew S. , Oshima Koichi , Pawinska-Wasikowska Katarzyna , Pieters Rob , Prater Mollie S. , Pruett-Miller Shondra M. , Pui Ching-Hon , Qu Chunxu , Reiterova Michaela , Reyes Noemi , Roberts Kathryn G. , Rowe Jacob M. , Sato Atsushi , Schmiegelow Kjeld , Schrappe Martin , Shen Shuhong , Skoczeń Szymon , Spinelli Orietta , Stary Jan , Svaton Michael , Takagi Masatoshi , Takita Junko , Tang Yanjing , Teachey David T. , Thomas Paul G. , Tomizawa Daisuke , Trka Jan , Varotto Elena , Vincent Tiffaney L. , Yang Jun J. , Yeoh Allen E.J. , Zhou Yinmei , Zimmermann Martin , Inaba Hiroto , Mullighan Charles G.
Published: October 2024

Comparison of clinical characteristics and outcomes between gamma delta T-ALL and non-gamma delta T-ALL.
Supplementary Table S19 from Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk
Authors: Kimura Shunsuke , Park Chun Shik , Montefiori Lindsey E. , Iacobucci Ilaria , Pölönen Petri , Gao Qingsong , Arnold Elizabeth D. , Attarbaschi Andishe , Brown Anthony , Buldini Barbara , Caldwell Kenneth J. , Chang Yunchao , Chen Chelsey , Cheng Cheng , Cheng Zhongshan , Choi John , Conter Valentino , Crews Kristine R. , de Groot-Kruseman Hester A. , Deguchi Takao , Eguchi Mariko , Muhle Hannah E. , Elitzur Sarah , Escherich Gabriele , Freeman Burgess B. , Gu Zhaohui , Han Katie , Horibe Keizo , Imamura Toshihiko , Jeha Sima , Kato Motohiro , Chiew Kean H. , Khan Tanya , Kicinski Michal , Köhrer Stefan , Kornblau Steven M. , Kotecha Rishi S. , Li Chi-Kong , Liu Yen-Chun , Locatelli Franco , Luger Selina M. , Paietta Elisabeth M. , Manabe Atsushi , Marquart Hanne V. , Masetti Riccardo , Maybury Mellissa , Mazilier Pauline , Meijerink Jules P.P. , Mitchell Sharnise , Miyamura Takako , Moore Andrew S. , Oshima Koichi , Pawinska-Wasikowska Katarzyna , Pieters Rob , Prater Mollie S. , Pruett-Miller Shondra M. , Pui Ching-Hon , Qu Chunxu , Reiterova Michaela , Reyes Noemi , Roberts Kathryn G. , Rowe Jacob M. , Sato Atsushi , Schmiegelow Kjeld , Schrappe Martin , Shen Shuhong , Skoczeń Szymon , Spinelli Orietta , Stary Jan , Svaton Michael , Takagi Masatoshi , Takita Junko , Tang Yanjing , Teachey David T. , Thomas Paul G. , Tomizawa Daisuke , Trka Jan , Varotto Elena , Vincent Tiffaney L. , Yang Jun J. , Yeoh Allen E.J. , Zhou Yinmei , Zimmermann Martin , Inaba Hiroto , Mullighan Charles G.
Published: October 2024

Differential peaks of H3K27ac and differentially expressed genes in gene-edited PF382 model.
Supplementary Fig. S5 from Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy
Authors: Choudhury Abrar , Cady Martha A. , Lucas Calixto-Hope G. , Najem Hinda , Phillips Joanna J. , Palikuqi Brisa , Zakimi Naomi , Joseph Tara , Birrueta Janeth O. , Chen William C. , Oberheim Bush Nancy A. , Hervey-Jumper Shawn L. , Klein Ophir D. , Toedebusch Christine M. , Horbinski Craig M. , Magill Stephen T. , Bhaduri Aparna , Perry Arie , Dickinson Peter J. , Heimberger Amy B. , Ashworth Alan , Crouch Elizabeth E. , Raleigh David R.
Published: October 2024

Supplementary Fig. 5. WHO grade 2 meningioma immunofluorescence microscopy for NOTCH3 and the mural cell marker SMA. NOTCH3 expression is primarily restricted to the perivascular niche and colocalizes with mural cells in meningiomas with WHO grade 2 histology. SF numbers indicate individual meningiomas. WHO grade defined using histological criteria. Representative of n=10 WHO grade 2 meningiomas. Scale bars, 10µm.
Supplementary Table S17 from Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk
Authors: Kimura Shunsuke , Park Chun Shik , Montefiori Lindsey E. , Iacobucci Ilaria , Pölönen Petri , Gao Qingsong , Arnold Elizabeth D. , Attarbaschi Andishe , Brown Anthony , Buldini Barbara , Caldwell Kenneth J. , Chang Yunchao , Chen Chelsey , Cheng Cheng , Cheng Zhongshan , Choi John , Conter Valentino , Crews Kristine R. , de Groot-Kruseman Hester A. , Deguchi Takao , Eguchi Mariko , Muhle Hannah E. , Elitzur Sarah , Escherich Gabriele , Freeman Burgess B. , Gu Zhaohui , Han Katie , Horibe Keizo , Imamura Toshihiko , Jeha Sima , Kato Motohiro , Chiew Kean H. , Khan Tanya , Kicinski Michal , Köhrer Stefan , Kornblau Steven M. , Kotecha Rishi S. , Li Chi-Kong , Liu Yen-Chun , Locatelli Franco , Luger Selina M. , Paietta Elisabeth M. , Manabe Atsushi , Marquart Hanne V. , Masetti Riccardo , Maybury Mellissa , Mazilier Pauline , Meijerink Jules P.P. , Mitchell Sharnise , Miyamura Takako , Moore Andrew S. , Oshima Koichi , Pawinska-Wasikowska Katarzyna , Pieters Rob , Prater Mollie S. , Pruett-Miller Shondra M. , Pui Ching-Hon , Qu Chunxu , Reiterova Michaela , Reyes Noemi , Roberts Kathryn G. , Rowe Jacob M. , Sato Atsushi , Schmiegelow Kjeld , Schrappe Martin , Shen Shuhong , Skoczeń Szymon , Spinelli Orietta , Stary Jan , Svaton Michael , Takagi Masatoshi , Takita Junko , Tang Yanjing , Teachey David T. , Thomas Paul G. , Tomizawa Daisuke , Trka Jan , Varotto Elena , Vincent Tiffaney L. , Yang Jun J. , Yeoh Allen E.J. , Zhou Yinmei , Zimmermann Martin , Inaba Hiroto , Mullighan Charles G.
Published: October 2024

Up-regulated pathways in PF382-STAG2KO (n = 4) compared to PF382-WT (n = 2) for LMO2 targets analyzed by gene-set enrichment analysis (GSEA).
Supplementary Fig. S4 from Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy
Authors: Choudhury Abrar , Cady Martha A. , Lucas Calixto-Hope G. , Najem Hinda , Phillips Joanna J. , Palikuqi Brisa , Zakimi Naomi , Joseph Tara , Birrueta Janeth O. , Chen William C. , Oberheim Bush Nancy A. , Hervey-Jumper Shawn L. , Klein Ophir D. , Toedebusch Christine M. , Horbinski Craig M. , Magill Stephen T. , Bhaduri Aparna , Perry Arie , Dickinson Peter J. , Heimberger Amy B. , Ashworth Alan , Crouch Elizabeth E. , Raleigh David R.
Published: October 2024

Supplementary Fig. 4. WHO grade 1 meningioma immunofluorescence microscopy for NOTCH3 and the mural cell marker SMA. NOTCH3 expression is restricted to the perivascular niche and colocalizes with mural cells in meningiomas with WHO grade 1 histology. SF numbers indicate individual meningiomas. WHO grade defined using histological criteria. Representative of n=10 WHO grade 1 meningiomas. Scale bars, 10µm.
Supplementary Table S15 from Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk
Authors: Kimura Shunsuke , Park Chun Shik , Montefiori Lindsey E. , Iacobucci Ilaria , Pölönen Petri , Gao Qingsong , Arnold Elizabeth D. , Attarbaschi Andishe , Brown Anthony , Buldini Barbara , Caldwell Kenneth J. , Chang Yunchao , Chen Chelsey , Cheng Cheng , Cheng Zhongshan , Choi John , Conter Valentino , Crews Kristine R. , de Groot-Kruseman Hester A. , Deguchi Takao , Eguchi Mariko , Muhle Hannah E. , Elitzur Sarah , Escherich Gabriele , Freeman Burgess B. , Gu Zhaohui , Han Katie , Horibe Keizo , Imamura Toshihiko , Jeha Sima , Kato Motohiro , Chiew Kean H. , Khan Tanya , Kicinski Michal , Köhrer Stefan , Kornblau Steven M. , Kotecha Rishi S. , Li Chi-Kong , Liu Yen-Chun , Locatelli Franco , Luger Selina M. , Paietta Elisabeth M. , Manabe Atsushi , Marquart Hanne V. , Masetti Riccardo , Maybury Mellissa , Mazilier Pauline , Meijerink Jules P.P. , Mitchell Sharnise , Miyamura Takako , Moore Andrew S. , Oshima Koichi , Pawinska-Wasikowska Katarzyna , Pieters Rob , Prater Mollie S. , Pruett-Miller Shondra M. , Pui Ching-Hon , Qu Chunxu , Reiterova Michaela , Reyes Noemi , Roberts Kathryn G. , Rowe Jacob M. , Sato Atsushi , Schmiegelow Kjeld , Schrappe Martin , Shen Shuhong , Skoczeń Szymon , Spinelli Orietta , Stary Jan , Svaton Michael , Takagi Masatoshi , Takita Junko , Tang Yanjing , Teachey David T. , Thomas Paul G. , Tomizawa Daisuke , Trka Jan , Varotto Elena , Vincent Tiffaney L. , Yang Jun J. , Yeoh Allen E.J. , Zhou Yinmei , Zimmermann Martin , Inaba Hiroto , Mullighan Charles G.
Published: October 2024

Differential peaks of H3K27ac and expression difference in gene-edited MOLT-14 model.
Supplementary Fig. S14 from Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy
Authors: Choudhury Abrar , Cady Martha A. , Lucas Calixto-Hope G. , Najem Hinda , Phillips Joanna J. , Palikuqi Brisa , Zakimi Naomi , Joseph Tara , Birrueta Janeth O. , Chen William C. , Oberheim Bush Nancy A. , Hervey-Jumper Shawn L. , Klein Ophir D. , Toedebusch Christine M. , Horbinski Craig M. , Magill Stephen T. , Bhaduri Aparna , Perry Arie , Dickinson Peter J. , Heimberger Amy B. , Ashworth Alan , Crouch Elizabeth E. , Raleigh David R.
Published: October 2024

Supplementary Fig. 14. Meningioma invasion of Virchow-Robin spaces. A, H&E low magnification (top) and high magnification (box, bottom) images of human meningioma invasion into perivascular fluid-filled cavities surrounding perforating vasculature of the brain. Densely cellular meningioma is shown at the top of each image, and islands of perivascular tumor within the brain parenchyma (dashed lines, bottom) are shown at the bottom of each image. Scale bars, 100µm. B, Low magnification (top) and high magnification (box, bottom) images of IHC for the brain parenchyma marker GFAP validates invasion of unlabeled meningioma cells into Virchow-Robin spaces without direct invasion of the brain parenchyma itself. C, IHC for the mural cell marker SMA (top) or the meningioma cell marker SSTR2A (bottom) validates meningioma invasion into Virchow-Robin spaces.
Supplementary Table S11 from Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk
Authors: Kimura Shunsuke , Park Chun Shik , Montefiori Lindsey E. , Iacobucci Ilaria , Pölönen Petri , Gao Qingsong , Arnold Elizabeth D. , Attarbaschi Andishe , Brown Anthony , Buldini Barbara , Caldwell Kenneth J. , Chang Yunchao , Chen Chelsey , Cheng Cheng , Cheng Zhongshan , Choi John , Conter Valentino , Crews Kristine R. , de Groot-Kruseman Hester A. , Deguchi Takao , Eguchi Mariko , Muhle Hannah E. , Elitzur Sarah , Escherich Gabriele , Freeman Burgess B. , Gu Zhaohui , Han Katie , Horibe Keizo , Imamura Toshihiko , Jeha Sima , Kato Motohiro , Chiew Kean H. , Khan Tanya , Kicinski Michal , Köhrer Stefan , Kornblau Steven M. , Kotecha Rishi S. , Li Chi-Kong , Liu Yen-Chun , Locatelli Franco , Luger Selina M. , Paietta Elisabeth M. , Manabe Atsushi , Marquart Hanne V. , Masetti Riccardo , Maybury Mellissa , Mazilier Pauline , Meijerink Jules P.P. , Mitchell Sharnise , Miyamura Takako , Moore Andrew S. , Oshima Koichi , Pawinska-Wasikowska Katarzyna , Pieters Rob , Prater Mollie S. , Pruett-Miller Shondra M. , Pui Ching-Hon , Qu Chunxu , Reiterova Michaela , Reyes Noemi , Roberts Kathryn G. , Rowe Jacob M. , Sato Atsushi , Schmiegelow Kjeld , Schrappe Martin , Shen Shuhong , Skoczeń Szymon , Spinelli Orietta , Stary Jan , Svaton Michael , Takagi Masatoshi , Takita Junko , Tang Yanjing , Teachey David T. , Thomas Paul G. , Tomizawa Daisuke , Trka Jan , Varotto Elena , Vincent Tiffaney L. , Yang Jun J. , Yeoh Allen E.J. , Zhou Yinmei , Zimmermann Martin , Inaba Hiroto , Mullighan Charles G.
Published: October 2024

Patient characteristics of 24 cases of STAG2/LMO2 subtype T-ALL that were performed genomic analysis.
Supplementary Fig. S1 from Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy
Authors: Choudhury Abrar , Cady Martha A. , Lucas Calixto-Hope G. , Najem Hinda , Phillips Joanna J. , Palikuqi Brisa , Zakimi Naomi , Joseph Tara , Birrueta Janeth O. , Chen William C. , Oberheim Bush Nancy A. , Hervey-Jumper Shawn L. , Klein Ophir D. , Toedebusch Christine M. , Horbinski Craig M. , Magill Stephen T. , Bhaduri Aparna , Perry Arie , Dickinson Peter J. , Heimberger Amy B. , Ashworth Alan , Crouch Elizabeth E. , Raleigh David R.
Published: October 2024

Supplementary Fig. 1. Single-cell RNA sequencing of human meningiomas with loss of chromosome 22q. A, Single-cell counts across UMAP clusters from human meningioma samples with loss of chromosome 22q analyzed using single-cell RNA sequencing. B, UMAP showing single-cell RNA sequencing of human meningioma samples shaded by sample of origin. C, Stacked bar plots showing the distribution of chromosome 22q loss (red) across single-cell RNA sequencing clusters from human meningioma samples. D, UMAP and stacked bar plot showing single-cell RNA sequencing cell cycle analysis across human meningioma samples. E-G, Heatmap and feature plots showing differentially expressed genes across UMAP clusters from human meningioma samples analyzed using single-cell RNA sequencing. Colors as in A. See also Supplementary Table 1. G, Feature plots showing expression of meningioma (SSTR2, PTGDS) or cancer stem-cell markers (NOTCH3, THY1) across UMAP clusters from human meningioma samples analyzed using single-cell RNA sequencing.
Supplementary Figure S8 from Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk
Authors: Kimura Shunsuke , Park Chun Shik , Montefiori Lindsey E. , Iacobucci Ilaria , Pölönen Petri , Gao Qingsong , Arnold Elizabeth D. , Attarbaschi Andishe , Brown Anthony , Buldini Barbara , Caldwell Kenneth J. , Chang Yunchao , Chen Chelsey , Cheng Cheng , Cheng Zhongshan , Choi John , Conter Valentino , Crews Kristine R. , de Groot-Kruseman Hester A. , Deguchi Takao , Eguchi Mariko , Muhle Hannah E. , Elitzur Sarah , Escherich Gabriele , Freeman Burgess B. , Gu Zhaohui , Han Katie , Horibe Keizo , Imamura Toshihiko , Jeha Sima , Kato Motohiro , Chiew Kean H. , Khan Tanya , Kicinski Michal , Köhrer Stefan , Kornblau Steven M. , Kotecha Rishi S. , Li Chi-Kong , Liu Yen-Chun , Locatelli Franco , Luger Selina M. , Paietta Elisabeth M. , Manabe Atsushi , Marquart Hanne V. , Masetti Riccardo , Maybury Mellissa , Mazilier Pauline , Meijerink Jules P.P. , Mitchell Sharnise , Miyamura Takako , Moore Andrew S. , Oshima Koichi , Pawinska-Wasikowska Katarzyna , Pieters Rob , Prater Mollie S. , Pruett-Miller Shondra M. , Pui Ching-Hon , Qu Chunxu , Reiterova Michaela , Reyes Noemi , Roberts Kathryn G. , Rowe Jacob M. , Sato Atsushi , Schmiegelow Kjeld , Schrappe Martin , Shen Shuhong , Skoczeń Szymon , Spinelli Orietta , Stary Jan , Svaton Michael , Takagi Masatoshi , Takita Junko , Tang Yanjing , Teachey David T. , Thomas Paul G. , Tomizawa Daisuke , Trka Jan , Varotto Elena , Vincent Tiffaney L. , Yang Jun J. , Yeoh Allen E.J. , Zhou Yinmei , Zimmermann Martin , Inaba Hiroto , Mullighan Charles G.
Published: October 2024

ChIP-seq coverage at the CD34 locus showing the effects of STAG2 inactivation.
Supplementary Figure S7 from Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk
Authors: Kimura Shunsuke , Park Chun Shik , Montefiori Lindsey E. , Iacobucci Ilaria , Pölönen Petri , Gao Qingsong , Arnold Elizabeth D. , Attarbaschi Andishe , Brown Anthony , Buldini Barbara , Caldwell Kenneth J. , Chang Yunchao , Chen Chelsey , Cheng Cheng , Cheng Zhongshan , Choi John , Conter Valentino , Crews Kristine R. , de Groot-Kruseman Hester A. , Deguchi Takao , Eguchi Mariko , Muhle Hannah E. , Elitzur Sarah , Escherich Gabriele , Freeman Burgess B. , Gu Zhaohui , Han Katie , Horibe Keizo , Imamura Toshihiko , Jeha Sima , Kato Motohiro , Chiew Kean H. , Khan Tanya , Kicinski Michal , Köhrer Stefan , Kornblau Steven M. , Kotecha Rishi S. , Li Chi-Kong , Liu Yen-Chun , Locatelli Franco , Luger Selina M. , Paietta Elisabeth M. , Manabe Atsushi , Marquart Hanne V. , Masetti Riccardo , Maybury Mellissa , Mazilier Pauline , Meijerink Jules P.P. , Mitchell Sharnise , Miyamura Takako , Moore Andrew S. , Oshima Koichi , Pawinska-Wasikowska Katarzyna , Pieters Rob , Prater Mollie S. , Pruett-Miller Shondra M. , Pui Ching-Hon , Qu Chunxu , Reiterova Michaela , Reyes Noemi , Roberts Kathryn G. , Rowe Jacob M. , Sato Atsushi , Schmiegelow Kjeld , Schrappe Martin , Shen Shuhong , Skoczeń Szymon , Spinelli Orietta , Stary Jan , Svaton Michael , Takagi Masatoshi , Takita Junko , Tang Yanjing , Teachey David T. , Thomas Paul G. , Tomizawa Daisuke , Trka Jan , Varotto Elena , Vincent Tiffaney L. , Yang Jun J. , Yeoh Allen E.J. , Zhou Yinmei , Zimmermann Martin , Inaba Hiroto , Mullighan Charles G.
Published: October 2024

Models for examining the effects of STAG2 inactivation.
Supplementary Figure S6 from Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk
Authors: Kimura Shunsuke , Park Chun Shik , Montefiori Lindsey E. , Iacobucci Ilaria , Pölönen Petri , Gao Qingsong , Arnold Elizabeth D. , Attarbaschi Andishe , Brown Anthony , Buldini Barbara , Caldwell Kenneth J. , Chang Yunchao , Chen Chelsey , Cheng Cheng , Cheng Zhongshan , Choi John , Conter Valentino , Crews Kristine R. , de Groot-Kruseman Hester A. , Deguchi Takao , Eguchi Mariko , Muhle Hannah E. , Elitzur Sarah , Escherich Gabriele , Freeman Burgess B. , Gu Zhaohui , Han Katie , Horibe Keizo , Imamura Toshihiko , Jeha Sima , Kato Motohiro , Chiew Kean H. , Khan Tanya , Kicinski Michal , Köhrer Stefan , Kornblau Steven M. , Kotecha Rishi S. , Li Chi-Kong , Liu Yen-Chun , Locatelli Franco , Luger Selina M. , Paietta Elisabeth M. , Manabe Atsushi , Marquart Hanne V. , Masetti Riccardo , Maybury Mellissa , Mazilier Pauline , Meijerink Jules P.P. , Mitchell Sharnise , Miyamura Takako , Moore Andrew S. , Oshima Koichi , Pawinska-Wasikowska Katarzyna , Pieters Rob , Prater Mollie S. , Pruett-Miller Shondra M. , Pui Ching-Hon , Qu Chunxu , Reiterova Michaela , Reyes Noemi , Roberts Kathryn G. , Rowe Jacob M. , Sato Atsushi , Schmiegelow Kjeld , Schrappe Martin , Shen Shuhong , Skoczeń Szymon , Spinelli Orietta , Stary Jan , Svaton Michael , Takagi Masatoshi , Takita Junko , Tang Yanjing , Teachey David T. , Thomas Paul G. , Tomizawa Daisuke , Trka Jan , Varotto Elena , Vincent Tiffaney L. , Yang Jun J. , Yeoh Allen E.J. , Zhou Yinmei , Zimmermann Martin , Inaba Hiroto , Mullighan Charles G.
Published: October 2024

The feature gene expression of STAG2/LMO2 subtype T-ALL.
Supplementary Figure S5 from Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High Risk
Authors: Kimura Shunsuke , Park Chun Shik , Montefiori Lindsey E. , Iacobucci Ilaria , Pölönen Petri , Gao Qingsong , Arnold Elizabeth D. , Attarbaschi Andishe , Brown Anthony , Buldini Barbara , Caldwell Kenneth J. , Chang Yunchao , Chen Chelsey , Cheng Cheng , Cheng Zhongshan , Choi John , Conter Valentino , Crews Kristine R. , de Groot-Kruseman Hester A. , Deguchi Takao , Eguchi Mariko , Muhle Hannah E. , Elitzur Sarah , Escherich Gabriele , Freeman Burgess B. , Gu Zhaohui , Han Katie , Horibe Keizo , Imamura Toshihiko , Jeha Sima , Kato Motohiro , Chiew Kean H. , Khan Tanya , Kicinski Michal , Köhrer Stefan , Kornblau Steven M. , Kotecha Rishi S. , Li Chi-Kong , Liu Yen-Chun , Locatelli Franco , Luger Selina M. , Paietta Elisabeth M. , Manabe Atsushi , Marquart Hanne V. , Masetti Riccardo , Maybury Mellissa , Mazilier Pauline , Meijerink Jules P.P. , Mitchell Sharnise , Miyamura Takako , Moore Andrew S. , Oshima Koichi , Pawinska-Wasikowska Katarzyna , Pieters Rob , Prater Mollie S. , Pruett-Miller Shondra M. , Pui Ching-Hon , Qu Chunxu , Reiterova Michaela , Reyes Noemi , Roberts Kathryn G. , Rowe Jacob M. , Sato Atsushi , Schmiegelow Kjeld , Schrappe Martin , Shen Shuhong , Skoczeń Szymon , Spinelli Orietta , Stary Jan , Svaton Michael , Takagi Masatoshi , Takita Junko , Tang Yanjing , Teachey David T. , Thomas Paul G. , Tomizawa Daisuke , Trka Jan , Varotto Elena , Vincent Tiffaney L. , Yang Jun J. , Yeoh Allen E.J. , Zhou Yinmei , Zimmermann Martin , Inaba Hiroto , Mullighan Charles G.
Published: October 2024

The genomic features of LMO2::STAG2 translocations.
Supplementary Figure S5 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify KDM3B as a Genotype-specific Vulnerability in IDH2- and TET2-mutant Cells
Authors: Waarts Michael R. , Mowla Shoron , Boileau Meaghan , Martinez Benitez Anthony R. , Sango Junya , Bagish Maya , Fernández-Maestre Inés , Shan Yufan , Eisman Shira E. , Park Young C. , Wereski Matthew , Csete Isabelle , O’Connor Kavi , Romero-Vega Angelica C. , Miles Linde A. , Xiao Wenbin , Wu Xiaodi , Koche Richard P. , Armstrong Scott A. , Shih Alan H. , Papapetrou Eirini P. , Butler Jason M. , Cai Sheng F. , Bowman Robert L. , Levine Ross L.
Published: October 2024

In vivo validation of Jmjd1c dependency
Supplementary Figure S7 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Authors: Donahue Katelyn L. , Watkoske Hannah R. , Kadiyala Padma , Du Wenting , Brown Kristee , Scales Michael K. , Elhossiny Ahmed M. , Espinoza Carlos E. , Lasse Opsahl Emily L. , Griffith Brian D. , Wen Yukang , Sun Lei , Velez-Delgado Ashley , Renollet Nur M. , Morales Jacqueline , Nedzesky Nicholas M. , Baliira Rachael K. , Menjivar Rosa E. , Medina-Cabrera Paola I. , Rao Arvind , Allen Benjamin , Shi Jiaqi , Frankel Timothy L. , Carpenter Eileen S. , Bednar Filip , Zhang Yaqing , Pasca di Magliano Marina
Published: October 2024

Figure S7: Tumor cell-initiated autocrine signaling drives IL-33 upregulation in pancreatic fibroblasts.
Supplementary Figure S6 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Authors: Donahue Katelyn L. , Watkoske Hannah R. , Kadiyala Padma , Du Wenting , Brown Kristee , Scales Michael K. , Elhossiny Ahmed M. , Espinoza Carlos E. , Lasse Opsahl Emily L. , Griffith Brian D. , Wen Yukang , Sun Lei , Velez-Delgado Ashley , Renollet Nur M. , Morales Jacqueline , Nedzesky Nicholas M. , Baliira Rachael K. , Menjivar Rosa E. , Medina-Cabrera Paola I. , Rao Arvind , Allen Benjamin , Shi Jiaqi , Frankel Timothy L. , Carpenter Eileen S. , Bednar Filip , Zhang Yaqing , Pasca di Magliano Marina
Published: October 2024

Figure S6: Expression of fibroblast IL-33 is extrinsically induced by epithelial KrasG12D and requires JAK1/2-STAT3 activation throughout tumorigenesis.
Supplementary Figure S4 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Authors: Donahue Katelyn L. , Watkoske Hannah R. , Kadiyala Padma , Du Wenting , Brown Kristee , Scales Michael K. , Elhossiny Ahmed M. , Espinoza Carlos E. , Lasse Opsahl Emily L. , Griffith Brian D. , Wen Yukang , Sun Lei , Velez-Delgado Ashley , Renollet Nur M. , Morales Jacqueline , Nedzesky Nicholas M. , Baliira Rachael K. , Menjivar Rosa E. , Medina-Cabrera Paola I. , Rao Arvind , Allen Benjamin , Shi Jiaqi , Frankel Timothy L. , Carpenter Eileen S. , Bednar Filip , Zhang Yaqing , Pasca di Magliano Marina
Published: October 2024

Figure S4: Loss of stromal IL-33 alters the ST2+ immune cell secretome, resulting in a shift in CAF differentiation.
Supplementary Figure S2 from Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Authors: Donahue Katelyn L. , Watkoske Hannah R. , Kadiyala Padma , Du Wenting , Brown Kristee , Scales Michael K. , Elhossiny Ahmed M. , Espinoza Carlos E. , Lasse Opsahl Emily L. , Griffith Brian D. , Wen Yukang , Sun Lei , Velez-Delgado Ashley , Renollet Nur M. , Morales Jacqueline , Nedzesky Nicholas M. , Baliira Rachael K. , Menjivar Rosa E. , Medina-Cabrera Paola I. , Rao Arvind , Allen Benjamin , Shi Jiaqi , Frankel Timothy L. , Carpenter Eileen S. , Bednar Filip , Zhang Yaqing , Pasca di Magliano Marina
Published: October 2024

Figure S2: Stromal IL-33 promotes PDA growth.
Data from Targeting Acute Myeloid Leukemia Stem Cells through Perturbation of Mitochondrial Calcium
Authors: Sheth Anagha Inguva , Althoff Mark J. , Tolison Hunter , Engel Krysta , Amaya Maria L. , Krug Anna E. , Young Tracy N. , Minhajuddin Mohammad , Pei Shanshan , Patel Sweta B. , Winters Amanda , Miller Regan , Shelton Ian T. , St-Germain Jonathan , Ling Tianyi , Jones Courtney L. , Raught Brian , Gillen Austin E. , Ransom Monica , Staggs Sarah , Smith Clayton A. , Pollyea Daniel A. , Stevens Brett M. , Jordan Craig T.
Published: October 2024

Abstract
Acute myeloid leukemia stem cells (LSCs) are uniquely reliant on oxidative phosphorylation (OXPHOS) for survival. Moreover, maintenance of OXPHOS is dependent on BCL-2, creating a therapeutic opportunity to target LSCs using the BCL-2 inhibitor venetoclax. Although venetoclax-based regimens have shown promising clinical activity, the emergence of drug resistance is prevalent. Thus, in the present study, we investigated how mitochondrial properties may influence venetoclax responsiveness. Our data show that utilization of mitochondrial calcium is fundamentally different between drug-responsive and nonresponsive LSCs. By comparison, venetoclax-resistant LSCs demonstrate an active metabolic (i.e., OXPHOS) status with relatively high levels of calcium. Consequently, we tested genetic and pharmacological approaches to target the mitochondrial calcium uniporter. We demonstrate that inhibition of calcium uptake reduces OXPHOS and leads to eradication of venetoclax-resistant LSCs. These findings demonstrate a central role for calcium signaling in LSCs and provide an avenue for clinical management of venetoclax resistance.

Significance: We identify increased utilization of mitochondrial calcium as a distinct metabolic requirement of venetoclax-resistant LSCs and demonstrate the potential of targeting mitochondrial calcium uptake as a therapeutic strategy.
Data from CD28 Costimulation Augments CAR Signaling in NK Cells via the LCK/CD3ζ/ZAP70 Signaling Axis
Authors: Acharya Sunil , Basar Rafet , Daher May , Rafei Hind , Li Ping , Uprety Nadima , Ensley Emily , Shanley Mayra , Kumar Bijender , Banerjee Pinaki P. , Melo Garcia Luciana , Lin Paul , Mohanty Vakul , Kim Kun H. , Jiang Xianli , Pan Yuchen , Li Ye , Liu Bin , Nunez Cortes Ana K. , Zhang Chenyu , Fathi Mohsen , Rezvan Ali , Montalvo Melisa J. , Cha Sophia L. , Reyes-Silva Francia , Shrestha Rejeena , Guo Xingliang , Kundu Kiran , Biederstädt Alexander , Muniz-Feliciano Luis , Deyter Gary M. , Kaplan Mecit , Jiang Xin R. , Liu Enli , Jain Antrix , Roszik Janos , Fowlkes Natalie W. , Solis Soto Luisa M. , Raso Maria G. , Khoury Joseph D. , Lin Pei , Vega Francisco , Varadarajan Navin , Chen Ken , Marin David , Shpall Elizabeth J. , Rezvani Katayoun
Published: October 2024

Abstract
Multiple factors in the design of a chimeric antigen receptor (CAR) influence CAR T-cell activity, with costimulatory signals being a key component. Yet, the impact of costimulatory domains on the downstream signaling and subsequent functionality of CAR-engineered natural killer (NK) cells remains largely unexplored. Here, we evaluated the impact of various costimulatory domains on CAR-NK cell activity, using a CD70-targeting CAR. We found that CD28, a costimulatory molecule not inherently present in mature NK cells, significantly enhanced the antitumor efficacy and long-term cytotoxicity of CAR-NK cells both in vitro and in multiple xenograft models of hematologic and solid tumors. Mechanistically, we showed that CD28 linked to CD3ζ creates a platform that recruits critical kinases, such as lymphocyte-specific protein tyrosine kinase (LCK) and zeta-chain-associated protein kinase 70 (ZAP70), initiating a signaling cascade that enhances CAR-NK cell function. Our study provides insights into how CD28 costimulation enhances CAR-NK cell function and supports its incorporation in NK-based CARs for cancer immunotherapy.

Significance: We demonstrated that incorporation of the T-cell–centric costimulatory molecule CD28, which is normally absent in mature natural killer (NK) cells, into the chimeric antigen receptor (CAR) construct recruits key kinases including lymphocyte-specific protein tyrosine kinase and zeta-chain-associated protein kinase 70 and results in enhanced CAR-NK cell persistence and sustained antitumor cytotoxicity.
Data from Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer
Authors: Sandoval Tito A. , Salvagno Camilla , Chae Chang-Suk , Awasthi Deepika , Giovanelli Paolo , Marin Falco Matias , Hwang Sung-Min , Teran-Cabanillas Eli , Suominen Lasse , Yamazaki Takahiro , Kuo Hui-Hsuan , Moyer Jenna E. , Martin M. Laura , Manohar Jyothi , Kim Kihwan , Sierra Maria A. , Ramos Yusibeska , Tan Chen , Emmanuelli Alexander , Song Minkyung , Morales Diana K. , Zamarin Dmitriy , Frey Melissa K. , Cantillo Evelyn , Chapman-Davis Eloise , Holcomb Kevin , Mason Christopher E. , Galluzzi Lorenzo , Ni Zhou Zhen , Vähärautio Anna , Cloonan Suzanne M. , Cubillos-Ruiz Juan R.
Published: October 2024

Abstract
Iron accumulation in tumors contributes to disease progression and chemoresistance. Although targeting this process can influence various hallmarks of cancer, the immunomodulatory effects of iron chelation in the tumor microenvironment are unknown. Here, we report that treatment with deferiprone, an FDA-approved iron chelator, unleashes innate immune responses that restrain ovarian cancer. Deferiprone reprogrammed ovarian cancer cells toward an immunostimulatory state characterized by the production of type-I IFN and overexpression of molecules that activate NK cells. Mechanistically, these effects were driven by innate sensing of mitochondrial DNA in the cytosol and concomitant activation of nuclear DNA damage responses triggered upon iron chelation. Deferiprone synergized with chemotherapy and prolonged the survival of mice with ovarian cancer by bolstering type-I IFN responses that drove NK cell-dependent control of metastatic disease. Hence, iron chelation may represent an alternative immunotherapeutic strategy for malignancies that are refractory to current T-cell–centric modalities.

Significance: This study uncovers that targeting dysregulated iron accumulation in ovarian tumors represents a major therapeutic opportunity. Iron chelation therapy using an FDA-approved agent causes immunogenic stress responses in ovarian cancer cells that delay metastatic disease progression and enhance the effects of first-line chemotherapy.

See related commentary by Bell and Zou, p. 1771
The Epigenetic Hallmarks of Cancer
Authors: Esteller Manel , Dawson Mark A. , Kadoch Cigall , Rassool Feyruz V. , Jones Peter A. , Baylin Stephen B.
Published: October 2024

Cancer is a complex disease in which several molecular and cellular pathways converge to foster the tumoral phenotype. Notably, in the latest iteration of the cancer hallmarks, “nonmutational epigenetic reprogramming” was newly added. However, epigenetics, much like genetics, is a broad scientific area that deserves further attention due to its multiple roles in cancer initiation, progression, and adaptive nature. Herein, we present a detailed examination of the epigenetic hallmarks affected in human cancer, elucidating the pathways and genes involved, and dissecting the disrupted landscapes for DNA methylation, histone modifications, and chromatin architecture that define the disease.

Significance: Cancer is a disease characterized by constant evolution, spanning from its initial premalignant stages to the advanced invasive and disseminated stages. It is a pathology that is able to adapt and survive amidst hostile cellular microenvironments and diverse treatments implemented by medical professionals. The more fixed setup of the genetic structure cannot fully provide transformed cells with the tools to survive but the rapid and plastic nature of epigenetic changes is ready for the task. This review summarizes the epigenetic hallmarks that define the ecological success of cancer cells in our bodies.
Transforming Cancer Research through Informatics
Authors: Klemm Juli D. , Singer Dinah S. , Mesirov Jill P.
Published: October 2024

For more than three decades, concurrent advances in laboratory technologies and computer science have driven the rise of cancer informatics. Today, software tools for cancer research are indispensable to the entire cancer research enterprise.
Ironing Out the Kinks: Arming Natural Killer Cells against Ovarian Cancer
Authors: Bell Hannah Noelle , Zou Weiping
Published: October 2024

Ameliorating the tumor immune microenvironment is a key strategy to improve the therapeutic outcomes of patients with cancer. Sandoval and colleagues demonstrate that iron chelation enhances type I IFN production, promotes NK cell tumor trafficking and activation, and synergizes with chemotherapy drug cisplatin to reduce metastatic ovarian cancer progression in murine models.

See related article by Sandoval et al., p. 1901
Cancer Genomes Sometimes Take the Longest Evolutionary Road
Authors: Taylor Alison M.
Published: October 2024

Baker and colleagues developed a new algorithm called “Gain Route Identification and Timing In Cancer” (GRITIC) to uncover the path of chromosomal evolution in a tumor, particularly in the context of whole-genome duplication. Their approach found that tumors with genome doubling frequently take an indirect path from one copy number state to another. In addition, the timing of genome doubling within a tumor’s evolution impacts its consequences on downstream chromosomal instability.

See related article by Baker et al., p. 1810
A New Era of Data-Driven Cancer Research and Care: Opportunities and Challenges
Authors: Gomez Felicia , Danos Arpad M. , Del Fiol Guilherme , Madabhushi Anant , Tiwari Pallavi , McMichael Joshua F. , Bakas Spyridon , Bian Jiang , Davatzikos Christos , Fertig Elana J. , Kalpathy-Cramer Jayashree , Kenney Johanna , Savova Guergana K. , Yetisgen Meliha , Van Allen Eliezer M. , Warner Jeremy L. , Prior Fred , Griffith Malachi , Griffith Obi L.
Published: October 2024

People diagnosed with cancer and their formal and informal caregivers are increasingly faced with a deluge of complex information, thanks to rapid advancements in the type and volume of diagnostic, prognostic, and treatment data. This commentary discusses the opportunities and challenges that the society faces as we integrate large volumes of data into regular cancer care.
Supplementary Table S3 from Health Disparities among Patients with Cancer Who Received Molecular Testing for Biomarker-Directed Therapy
Authors: Heath Elisabeth , Dyson Gregory , Ribeiro Jennifer R. , Xiu Joanne , Poorman Kelsey , Mamdani Hirva , Al-Hallak Mohammed N. , Shields Anthony F. , Elayoubi Jailan A. , Winer Ira S. , Cackowski Frank C. , Puckrein Gary A. , Lopes Gilberto de Lima , Jones Nathaniel , Hauke Ralph J. , Kareff Samuel A. , Radovich Milan , Sledge George W. , Spetzler David B. , Vidal Gregory A. , Marshall John L.
Published: October 2024

COXPH model for patients with stage information
Supplementary Table S2 from Health Disparities among Patients with Cancer Who Received Molecular Testing for Biomarker-Directed Therapy
Authors: Heath Elisabeth , Dyson Gregory , Ribeiro Jennifer R. , Xiu Joanne , Poorman Kelsey , Mamdani Hirva , Al-Hallak Mohammed N. , Shields Anthony F. , Elayoubi Jailan A. , Winer Ira S. , Cackowski Frank C. , Puckrein Gary A. , Lopes Gilberto de Lima , Jones Nathaniel , Hauke Ralph J. , Kareff Samuel A. , Radovich Milan , Sledge George W. , Spetzler David B. , Vidal Gregory A. , Marshall John L.
Published: October 2024

COXPH model for patients with at least 6-mo overall survival
Supplementary Figure S5 from Health Disparities among Patients with Cancer Who Received Molecular Testing for Biomarker-Directed Therapy
Authors: Heath Elisabeth , Dyson Gregory , Ribeiro Jennifer R. , Xiu Joanne , Poorman Kelsey , Mamdani Hirva , Al-Hallak Mohammed N. , Shields Anthony F. , Elayoubi Jailan A. , Winer Ira S. , Cackowski Frank C. , Puckrein Gary A. , Lopes Gilberto de Lima , Jones Nathaniel , Hauke Ralph J. , Kareff Samuel A. , Radovich Milan , Sledge George W. , Spetzler David B. , Vidal Gregory A. , Marshall John L.
Published: October 2024

Copy number alterations (CNAs) and fusions among cohort
Trichophyton soudanense, Trichophyton violaceum, and Trichophyton tonsurans in Munich: Travel- and Migration-Related Cutaneous Fungal Infections
Authors: Hoffmann Liv C. , French Lars E. , Reinholz Markus , Sárdy Miklós , Wollenberg Andreas , Kerschnitzki Annette , Horváth Orsolya N.
Published: October 2024

Introduction: Trichophyton soudanense, Trichophyton violaceum, and Trichophyton tonsurans are considered rare pathogens in Germany. They are presumed to infect people from Germany when they are traveling to tropical and subtropical areas. The incidence and the mode of infection with these three fungal pathogens in Munich were investigated to assess their significance for clinical practice. Methods: This monocentric study was conducted at a large European academic dermatology department in Munich from January 1, 2011, till August 30, 2020. We performed a retrospective analysis of medical data of all out- and inpatients presenting at our hospital with a suspected cutaneous fungal infection. Results: A total of 87,229 swabs were collected from 48,916 patients; 11,513 (13.2%) cultures confirmed a fungal infection. One of the three aforementioned dermatophytes was detected in 247 (2.1%) samples. The average patient age was 15.5 years (0–84 years, SD: 15.6) at the time of infection. T. tonsurans was the confirmed pathogen in 137 (55.5%) samples with increasing frequency over time. T. tonsurans spread in 11 cases through close contact with humans (kindergarten, martial arts, accommodation for asylum seekers). T. violaceum was detected in 88 (35.6%) samples with a peak in 2016 and 2017. T. soudanense was detected in 22 (8.9%) samples. A total of 46.7% of all tinea capitis cases were caused by one of these pathogens. Conclusion: In case of tinea capitis, a travel history should be performed and rare fungal infections should be considered in the differential diagnosis.
The Cocoon of the Developing Emerald Jewel Wasp (Ampulex compressa) Resists Cannibalistic Predation of the Zombified Host
Authors: Catania Kenneth C.
Published: October 2024

Introduction: To reproduce, the parasitoid emerald jewel wasp (Ampulex compressa) envenomates an American cockroach (Periplaneta americana) and barricades it in a hole with an egg on the host’s leg. The larval wasp feeds externally before entering the host and consuming internal organs before forming a cocoon inside the host carcass. Methods: The vulnerability of jewel wasp larvae to predation by juvenile cockroaches was investigated, and data were recorded with time-lapse videography. Results: Cockroaches were found to be predators of parasitized hosts. When parasitized cockroaches were exposed to hungry cockroaches on days 0–8 of development, the developing larva was killed. Eggs were dislodged or consumed, larvae on the leg were eaten, and larvae inside the host were eaten along with the host. On day 9, 80% of the wasp larvae were killed and eaten along with the host. Conversely, on day 10, 90% of the larvae survived. On developmental day 11 or later, the wasp larva always survived, although the host carcass was consumed. Survival depended entirely on whether the cocoon had been completed. Conclusion: The results highlight the vulnerability of larvae to predation and suggest the cocoon defends from insect mandibles. This may explain the unusual feeding behavior of the jewel wasp larvae, which eat the host with remarkable speed, tapping into the host respiratory system in the process, and consuming vital organs early, in contrast to many other parasitoids. Results are discussed in relation to larval wasp behavior, evolution, and development, and potential predators are considered.