bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting First-Line VEGFR-TKI Resistance and Survival in Metastatic Clear Cell Renal Cell Carcinoma Using a Clinical-Radiomic Nomogram
Authors: Wang Yichen , Zhang Xinxin , Wang Sicong , Shi Hongzhe , Zhao Xinming , Chen Yan
Published: April 2024

Background：This study aims to construct predicting models using radiomic and clinical features in predicting first-line vascular endothelial growth factor receptor-tyrosine kinase inhibitor (VEGFR-TKI) early resistance in metastatic clear cell renal cell carcinoma (mccRCC) patients. We also aim to explore the correlation of predicting models with short and long-term survival of mccRCC patients.
Materials and Methods：In this retrospective study, 110 mccRCC patients from 2009 to 2019 were included and assigned into training and test sets. Radiomic features were extracted from tumor 3D-ROI of baseline enhanced CT images. Radiomic features were selected by Lasso method to construct a radiomic score. A combined nomogram was established using the combination of radiomic score and clinical factors. The discriminative abilities of the radiomic, clinical and combined nomogram were quantified using ROC curve. Cox regression analysis was used to test the correlation of nomogram score with progression-free survival (PFS) and overall survival (OS). PFS and OS were compared between different risk groups by log-rank test.
Results：The radiomic, clinical and combined nomogram demonstrated AUCs of 0.81, 0.75, and 0.83 in training set; 0.79, 0.77, and 0.88 in test set. Nomogram score≥1.18 was an independent prognostic factor of PFS (HR 0.22 (0.10, 0.47), p<0.001) and OS (HR 0.38 (0.20, 0.71), p=0.002), in training set. PFS in low-risk group were significantly longer than high-risk group in training (p<0.001) and test (p<0.001) set, respectively. OS in low-risk group were significantly longer than high-risk group in training (p=0.003) and test (p=0.009) set, respectively.
Conclusion：A nomogram combining baseline radiomic signature and clinical factors helped detecting first-line VEGFR-TKI early resistance and predicting short and long-term prognosis in mccRCC patients.
Gastrointestinal system endoscopy and pathological findings in non-dialysis chronic kidney disease: A single-centre study
Authors: Usta Mehmet , Ersoy Alparslan , Şensoy Nazife Nur Özer , Özel Mustafa , Akgür Suat , Kaynarca Önder Buğra , Ortaç Hatice
Published: April 2024

Different gastrointestinal complications may occur as a result of moderate and severe loss of kidney function in chronic kidney disease (CKD). This study examined upper gastrointestinal tract endoscopy and pathology findings in CKD patients with renal failure who were not receiving dialysis treatment. Method This study included 60 pre-dialysis CKD patients who underwent endoscopic examination due to dyspeptic complaints (CKD group. Endoscopic and pathological findings were compared with those of non-uremic patients (non-CKD group) with similar complaints. Results There was no difference in the frequency of gastroesophageal reflux in both groups. The rates of non-ulcerative lesions, esophagitis, antral gastritis, erythematous gastritis and active chronic gastritis were significantly higher in the CKD group than in the non-CKD group (p < 0.001). Erosive pangastritis was significantly higher in the non-CKD group. The frequency of ulcerative lesions was similar in both groups. There was no significant difference in the rates of intestinal metaplasia, atrophy and metaplastic gastritis. The frequency of Helicobacter pylori was significantly higher in the non-CKD group (p < 0.001). Conclusion Our findings show that some upper gastrointestinal system disorders are more common in non-dialysis CKD patients than non-uremic individuals, but Helicobacter pylori frequency is lower.
Developing a Model for the Success of Healthcare Start-up Companies in Iran: A Systematic Review and Interviews with Experts
Authors: Majedi Navid , Meskarpour-Amiri Mohammad , Yaghoubi Maryam
Published: April 2024

Background:In the dynamic landscape of healthcare, start-ups drive transformative change. Understanding the pivotal factors influencing their success is paramount to their advancement. This study aims to present a comprehensive framework delineating the drivers of success for emerging businesses in healthcare.Methods:Employing a mixed-method approach, this research integrates expert interviews and a systematic review of pertinent literature. Extensive scientific exploration across databases, augmented by manual searches and expert surveys, identified 57 influential factors from 37 selected articles and interviews. Through expert consultations, additional factors were incorporated, culminating in an 11-dimensional classification. Finally, the position of the factors in 4 stages (before starting the business, during the activity, evaluation, control and feedback) was determined, and the final model was extracted.Results:Based on the inclusion and exclusion criteria, a total of 37 articles were reviewed. Eleven dimensions were utilized to classify the 57 factors identified in this study. The factors "choosing the appropriate marketing and advertising strategy" and "targeting how to finance the business" had the highest number of repetitions in the studies; 49% of these factors were related to the stage "before starting the business", and 33% were related to "during activity".Discussion: To ensure growth and development at various stages of business formation, founders of start-up businesses in the healthcare sector need to carefully consider the factors that impact success, particularly business financing and marketing and advertising strategies.
Telemedicine (Mobile Phone Technologies) Interventions to Support Perceptions and Medication Adherence Among HIV-Positive
Authors: Marisa Dewi Erna , Wati Nenden Lesmana , Sary Yeyen Desiar Firda , Indah Fenita Purnama Sari , Afra Nada , Andiyan Andiyan
Published: April 2024

The objective was to develop and validate the use of Telemedicine to increase perception and medication adherence in PLWHA. The research design was pre-experimental with a one-group pretest- posttest design. Before data collection, a Telemedicine application was developed by the researcher. The intervention was for two months, with a pretest and a posttest conducted after it. The sample was 117 HIV/AIDS patients in Banten Province. The results indicated significant differences in perceived threat, perceived susceptibility, and medication adherence between pre-test and post-test. Telemedicine (Mobile phone technologies) was found to be effective in increasing perception and medication adherence in PLWHA.
Encapsulation of betalains extracted from Beta vulgaris L.pomace powder using different hydrocolloids and its characterization
Authors: Kaur Akashdeep , Ghoshal Gargi
Published: April 2024

The pomace of beetroot (Beta vulgaris L.) is rich in phenolic compounds and betalains, which makes it a possible source of functional components. However, the efficacy of the aforementioned bioactives may diminish during storage when subjected to adverse conditions such as high temperature, exposure to light, or oxidation by air, thereby potentially limiting their utility. This study compared the freeze-dried encapsulation of three different gums with ultrasound assistance to improve the stability and bio-accessibility of BRP extract. The properties of each encapsulated formulation were thoroughly investigated, encompassing functional and physicochemical attributes, betalains content, antioxidant activity, phenolic compounds, color analysis, morphology, FTIR, particle size, XRD, zeta potential, and microscopy. Notably, characteristics conducive to stability, such as low humidity levels and reduced hygroscopicity, were meticulously observed and recorded for each encapsulation formulation. For betalains, the encapsulation efficiency ranged from 84.79–94.56%. Guar gum (GG), acacia gum (AG), and tragacanth gum (TG) were the three different hydrocolloids that were chosen to encapsulate betalains. Encapsulation of BRP extract with GG resulted in enhanced bioaccessibility of bioactive constituents, as evidenced by observations in AG and TG. The findings imply that natural fruit and vegetable wastes ought to be further investigated as they could serve as promising sources to enhance the production of encapsulated pigments.
Transcriptional activation of Carbonic Anhydrase III (CAIII) mediated by SP1
Authors: Okuyan Derya , Köçkar Feray
Published: April 2024

Many physiological and pathological processes require the expression and control of CAIII. Although the CAIII promoter has not been fully characterized, promoters for other carbonic anhydrase genes in humans have. In this research, we for the first time located and described the human Carbonic anhydrase III gene promoter region. Progressive deletion analysis of the 5′-flanking region of the CAIII gene showed that the CAIII core promoter is mainly restricted to a minimum region of 129 bp. The CAIII gene promoter was discovered to include additional potential binding sites for transcriptional factors including C/EBP and NF-B despite lacking the standard TATA box, according to an investigation of transcriptional factor binding. Furthermore, site-directed mutagenesis assay showed that the proximal Sp1 binding site is required for the essential core promoter activity of the CAIII gene. It was also shown that the CAIII gene was up-regulated by SP1 at the mRNA and protein levels, and this effect was also observed in deletion promoter constructs. Our current study will shed light on further studies on the mechanism that regulates the expression of this important gene.
Unusual Case of Meandering Bullet in the Pericardial Cavity: Surgical Management and Clinical Considerations
Authors: Al-Amry Ali Lotf , Shamsan Abdu , Al-Eryani Raidan , A-Moghni Yasser , Jowah Haitham Mohammed
Published: April 2024

Foreign bodies of the pericardium are rare and are most commonly associated with significant trauma. With no associated injury in the myocardium, the finding of a meandering bullet alone in the pericardial cavity is rare. This is a case of an 18-year-old patient who came to the emergency room of 48 Model Hospital with a penetrating chest trauma associated with hemothorax and pneumothorax. The patient complained of dyspnea and chest pain during the presentation. Tube thoracostomy was performed on the day of admission. CT, fluoroscopy, and echocardiography show pericardial effusion and bullets are floating in the pericardial space. On the sixth day of admission, the patient underwent Lt thoracotomy and pericardiotomy with bullet removal. The patient was discharged on the 10th postoperative day. Despite reports supporting conservative management, surgical removal of the foreign body is recommended in cases of free bullets in the pericardial sac due to the high risk of developing clinical manifestations, pericarditis, and potential complications such as cardiac tamponade. The potential risks and damage caused by the foreign body should be carefully considered, outweighing the uncertain outcomes and complications associated with conservative treatment.
Rural-Urban Migration and Mental Health: A Study on India's Elderly Population
Authors: Paul Manoj , Mandal Sourav
Published: April 2024

Background
In recent years, India has witnessed a significant rise in rural-to-urban migration among its elderly population, posing distinct challenges, particularly concerning later-life health outcomes. Present study aims to examine the association between rural-urban migration in later life and mental health among elderly individuals currently residing in urban area.
Method
Using data from the Longitudinal Ageing Study (LASI) 2017-18 of India present study (n = 4529) applied bivariate analysis, logistic regression. Factors associated with depression is determine by logistic regression. However, Fairlie decomposition employed to show differences between depression between the rural-urban migrant elderly and non-migrant elderly populations.
Results
The findings reveal around a 22 percent of the study's participants, especially females [OR: 1.62, CI: 1.06–2.48] and wealthy people are migrated from rural to urban areas and continuously residing in urban areas since last ten years. Further, the study examines that migrating from rural to urban areas after the age of 50 and adapting to the new urban environment are linked with a higher likelihood of depression [OR:1.68, CI 0.93–2.17] among the elderly compared to their urban-native. Additionally, socio-demographic factors such as higher education and greater wealth significantly influence depressive symptoms. Notably, elderly individuals who co-reside with their spouse and children [OR: 0.62, CI: 0.34–1.13] tend to experience lower levels of depression, although this is intricately tied to decisions regarding their current place of residence.
Conclusion
Disparities in depression levels among elderly are accelerated by factors such as lower education, low wealth, living arrangements, and decisions regarding current residence when it collides with migration status. Consequently, there is a pressing need for governmental intervention aimed at bolstering economic security and establishing robust social support systems to bolster the mental well-being of India's elderly population.
Capsaicin-entangled Multi-walled Carbon Nanotubes against Breast cancer: A Theoretical and Experimental Approach
Authors: Radhakrishna Govardhan Katta , Ramesh Sameera Hammigi , Almeida Shannon D , Sireesha Golla , Ramesh Soundarya , Theivendren Panneerselvam , Chidamabaram Kumarappan , Ammunje Damodar Nayak , Kunjiappan Selvaraj , Pavadai Parasuraman
Published: April 2024

The incidence of breast cancer has gradually increased of late due to many etiological factors. Conventional treatment strategies suffer from a lack of solubility, low bioavailability at the target site, lack of target specificity, and indiscriminate drug distribution which leads to drug resistance. The present study aimed to deliver capsaicin into breast cancer cells through folic acid-conjugated capsaicin-loaded carboxylic acid-functionalised multi-walled carbon nanotubes (FA-CAP-COOHMWCNTs). FA-CAP-COOHMWCNTs was formulated and characterized by FTIR, SEM, TEM, XRD, zeta potential, and particle size analyser. In silico studies demonstrated that the active molecule, capsaicin can strongly bind onto C-SRC kinase receptor to suppress cancer progression. The in-vitro cellular viability of MCF-7 after 24 h treatment with 100 µg × mL-1 of FA-CAP-COOHMWCNTs was found to be 29.27±2.59%and IC50 value was observed to be 22.71 µg × mL-1. Subsequently, in vivo anticancer activity of FA-CAP-COOHMWCNTs was performed against 7,12-dimethylbenz(a) anthracene (DMBA)-induced breast cancer in female Wistar rats. After 21 days of treatment with FA-CAP-COOHMWCNTs, breast cancer-induced rats showed a significant reduction in mammary tumor size, along with elevated levels of antioxidant and detoxifying enzymes in serum/breast tissue. The medium dose (5 mg × kg-1 b.w) FA-CAP-COOHMWCNTs showed the maximum antioxidant properties with a significant reduction in tumor size, almost equivalent to the standard drug, Doxorubicin. Histopathological studies also showed near-normal architecture of breast tissue. Altogether, it can be interpreted that FA-CAP-COOHMWCNTs have antiproliferative efficacy of breast tumor progression in breast cancer-induced rats.
Interaction between the sphingolipid membrane rafts and the concentration of the amyloid complex and analyses
Authors: Nutini Alessandro , Sohail Ayesha
Published: April 2024

Amyloidosis diseases are a heterogeneous group of pathologies that have a strong impact on current society both in global health and in the economic system of each country. The analysis of how the entry of the toxic species identified into the amyloid oligomeric elements occurs is the main objective of much research in the sector. In this work, we analyze a hypothesis of the entry of oligomers into the membrane whereby, after a massive recruitment of the sphingolipid rafts thanks to their connection with the oligomers, a cleansing of the membrane itself occurs. This pathological event creates a sort of pore which, subsequently stabilized, allows the oligomers to enter the cell. In this work, we build an entry model based on dynamic networks that investigates the fundamental mechanisms that lead to the entry of amyloid oligomers into the cell after having formed a critical concentration in the oligomer-membrane complex which, thanks to the conformational changes affecting the oligomers themselves, carries out the cleansing of the membrane and the entry of these pathogenic elements. The global dynamic network is divided into subnetworks which are expressed by algorithms that identify both time and threshold concentration as the fundamental moment in triggering the entire pathological process.
A framework to predict zoonotic reservoirs under data uncertainty: a case study on betacoronaviruses
Authors: Tonelli Andrea , Blagrove Marcus , Wardeh Maya , Marco Moreno Di
Published: April 2024

1. Modelling approaches aimed at identifying currently unknown hosts of zoonotic diseases have the potential to make high-impact contributions to global strategies for zoonotic risk surveillance. However, geographical and taxonomic biases in host-pathogen associations might influence reliability of models and their predictions. 2. Here we propose a methodological framework to mitigate the effect of biases in host–pathogen data and account for uncertainty in models’ predictions. Our approach involves identifying “pseudo-negative” species and integrating sampling biases into the modelling pipeline. We present an application on the Betacoronavirus genus and provide estimates of mammal-borne betacoronavirus hazard at the global scale. 3. We show that the inclusion of pseudo-negatives in the analysis improves the overall performance of our model significantly (AUC = 0.82 and PR-AUC = 0.48, on average) compared to a model that does not use pseudo-negatives (AUC = 0.75 and PR-AUC = 0.39, on average), reducing the rate of false positives. Results of our application unveil currently unrecognised hotspots of betacoronavirus hazard in subequatorial Africa, and South America. 4. Our approach addresses crucial limitations in host–virus association modelling, with important downstream implications for zoonotic risk assessments. The proposed framework is adaptable to different multi-host disease systems and may be used to identify surveillance priorities as well as knowledge gaps in zoonotic pathogens’ host-range.
Elite Sport: Values and Goals for Athletes with Spinal Cord Injury
Authors: Fizzotti Gabriella , Tsampas Nikolas , Vigorelli Vanessa
Published: April 2024

Introduction: Sport’s ability to challenge social paradigm and boost self-esteem has made it an important tool to empower people in disability world. An elite athlete is defined who has reached the highest level of performance in a particular sport.
Material and Methods: 19 elite athletes, eleven males, eight females, were recruited. A semi structured interview guide was employed with the goal of gaining specific information and making better comparison.
Results: Through the evaluation of the questionnaires four themes emerged: challenge, rebirth, empowerment and icon.
Conclusion: According to literature this paper indicates that sports can have significant physical and psychosocial health benefits for people with disability. Sports provide a great social environment and can be a tool to overcome social barriers.
Protomix: A Python Package for 1H-NMR Data Preprocessing
Authors: Zniber Mohammed , Huynh Tan-Phat
Published: April 2024

Background
NMR-based metabolomics is a field driven by technological advancements, necessitating the use of advanced preprocessing tools. Despite this need, there is a remarkable scarcity of comprehensive and user-friendly preprocessing tools. To bridge this gap, we have developed Protomix – a Python package designed for metabolomics research. Protomix offers a set of automated, efficient, and user-friendly signal processing steps, tailored to streamline, and enhance the preprocessing phase in metabolomics studies.
Results
This package presents a comprehensive preprocessing pipeline compatible with various data analysis tools. It encompasses a suite of functionalities for data extraction, preprocessing, and interactive visualization. Additionally, it includes a tutorial in the form of a Python Jupyter notebook, specifically designed for the analysis of 1D 1H-NMR metabolomics data related to prostate cancer and benign prostatic hyperplasia.
Conclusions
Protomix simplifies the preprocessing phase and incorporates interactive data visualization, making it accessible to researchers of varying programming skills. Ongoing development and optimization will continue to solidify its contribution to the metabolomics field.
Impact of teacher training in computational thinking on educational innovation and use of Artificial Intelligence
Authors: Vidal Inés María González , García María del Carmen Romero , González Alain Antonio Rodríguez
Published: April 2024

The increase in virtual educational spaces has meant that teachers develop digital skills required in the 21st century. However, few studies explore teacher training in virtual environments linked to the concept of universalization of computational thinking to improve their performance in virtual teaching environments. The objective of this work is to analyze the impact of teacher training in universalization of computational thinking to enhance educational innovation in virtual teaching environments and the use of artificial intelligence (AI). Supported by the Google Scholar, Scopus and Springerlink databases, a systematic review of 75 scientific publications was carried out, using quantitative and qualitative scientific methods, as well as the Prism Model, which allowed organizing quality and selection criteria. The results show that the definition of computational thinking changes as its understanding materializes and develops in new generations of teachers based on a contemporary vision of the concept applied to all citizens. The curricular integration of programming and robotics in teacher training improves their digital literacy. At the same time, the educational practices resulting from the dual dialectic: experiment-conceptualize and act-reflect, supported by Kold's model, could favor educational innovation and the use of AI in educational environments within an ethical and social framework. The TRACK model is pointed out as a strategy to implement computational thinking in teacher training, considering three types of knowledge (namely: technological, pedagogical and the contents of the discipline) necessary for STEAM education, as well as improving teacher performance. in virtual teaching environments.
A novel murine model of infective endocarditis mimics human pathophysiology
Authors: Bartsch Benedikt , Ackerschott Ansgar , Zaidi Muntadher Al , Jamin Raul Nicolas , Nazir Mariam Louis Fathy , Altrogge Moritz , Fester Lars , Lambertz Jessica , Coburn Mark , Nickenig Georg , Zimmer Sebastian , Weisheit Christina Katharina
Published: April 2024

Incidence of Infective endocarditis (IE) and its mortality rate despite optimal medical therapy remain high. Early diagnosis and treatment initiation are challenging because the involved immunological processes are poorly understood due to a lack of suitable in vivo models and their difference to human pathophysiology.
Objectives:
To establish a novel reproducible murine IE model, based on wire injury (WI) induced endothelial damage.
Methods:
IE was established by inducing endothelial damage via wire injury followed by bacterial challenge with S. aureus using 104–6 colony-forming units (CFU). Cross-sections of valvular leaflets were prepared for scanning electron microscopy (SEM) and immunofluorescence microscopy to visualize valvular invasion of macrophages, neutrophils, and S. aureus. Bacterial cultivation was carried out from blood and valve samples.
Results:
Wire injury induced endothelial damage was observed in all mice after wire-injury in SEM imaging. We reliably induced IE using 105 (85%) and 106 (91%) CFU S. aureus after wire injury. We found significant neutrophilia in the blood and increased valvular immune cell and bacterial accumulations in IE mice.
Conclusion:
Our model allows for reliable IE induction and analysis of bacterial vegetation and immune cell infiltration in vivo and ex vivo. Valvular immune cell infiltration was similar to human pathophysiology.
Reconv: Repeated Convolutional Strategies for Advanced Image Inpainting
Authors: Jini.P  , K.K Rajkumar
Published: April 2024

Image inpainting is a promising but challenging approach that fills in huge free-form empty areas in images. Most of the recent papers concentrate on splitting masked image into two matrices of valid and invalid elements which makes the system more complex. This paper proposes a novel algorithm named ReConv which uses a repeated standard convolution operation which treats valid and invalid elements of an image in the same manner. The outcomes of our suggested method, ReConv, shows that, in comparison to earlier approaches, our system produces outputs that are more adaptable with good quality for real world applications. Our suggested technique enables users quickly modify faces, eliminate distracting items, change image layouts, and remove unwanted text. An extensive comparison study on two types of datasets validates our method. The effectiveness of the suggested strategy was evaluated using different measures such as PSNR, SSIM and FID. The results show that our recommended approach excels in performance compared to the existing modern methods.
Decoding Cyber Threats: Advanced Techniques In Malware Detection, Analysis, and URL Detection
Authors: Padole Geeta , Annareddy Ruthvik Reddy , Mothukuri Avinash , Aela Abhiram , Varma Koushik
Published: April 2024

The digital security landscape keeps on changing, with malware posing an extraordinary and growing threat across various cyber domains. Malware or malicious software is getting more complicated as it uses different techniques to enter systems, exploit their weaknesses and compromise the integrity of data in them. The increasing number of malware attacks can be attributed to the rapid developments in technology and the increased connectivity through internet that gives better avenues for attackers.
To mitigate these threats, this paper presents a project that combines advanced machine learning techniques aimed at generating powerful analysis tools for both URL and malware detection thereby distinguishing itself from traditional approaches depending on signature-based detection and heuristic methods only. XGBoost and LightGBM algorithms are used in URL analysis to classify URLs based on their structural properties or patterns which distinguish benign URLs from malicious ones. Therefore, this enables early warning systems before users click on any web link. On the other hand, malware analysis is focused on examining executable files to determine whether they are safe or not. It incorporates a wide range of machine learning algorithms such as Random Forest, KNN, Logistic Regression and Gradient Boosting beyond conventional signature-based antivirus methods. This approach allows for the dynamic learning from new malware behaviors, improving detection rates and adapting to evolving threats.
Antimycobacterial and anticancer properties of Myrtus communis leaf extract
Authors: Mir Mushtaq A. , Memish Lamis Ahmad , Elbehairi Serag Eldin , Bashir Nasreena , Saif Faris , Shati Ali A. , Alfaifi Mohammad Y. , Alamri Ahmad M. , Alkahtani Sultan Ahmad , Ahmad Irfan
Published: April 2024

Background: Plant-derived products or extracts are widely used in folk/traditional medicine to treat several infections, ailments, or disorders. A well-known medicinal herb, Myrtus communis is an evergreen fragrant plant native to the Mediterranean region that has been used for ages in traditional medicine around the world.
Materials and methods: The microplate alamarBlue assay and the well diffusion method were used to evaluate the zone of inhibition and MIC, respectively. Double disc diffusion method was used to investigate the synergy between antibiotics and the extract. Crystal violet method was used to investigate the biofilm development. The SulphoRhodamine-B assay and DNA flow cytometry were used to investigate the proliferation and subsequent distribution of cells among different phases of the cell cycle. The apoptotic and necrotic phases of the cancer cells were examined using flow cytometry in conjunction with Annexin V-FITC/PI labeling. Using the IBM SPSS statistical program, a one-way ANOVA with Tukey's post-hoc test was employed for statistical analysis.
Results: The ethanolic leaf extract of M. communis showed a strong growth inhibitory effect (zone of inhibition: 20.3±1.1 - 26.3±2.5 mm, MIC: 4.88 - 312.5 µg/mL, and MBC: 39.07 - 1250 μg/mL) against several rapid and slow-growing mycobacterial strains in a dose-dependent manner. Damage to the cell wall of bacterial cells was determined to be the cause of the antimycobacterial action. The extract inhibited the biofilm formation (MBIC of 9.7 µg/mL) and eradicated the already formed mature and ultra-mature biofilms of M. smegmatis with MBEC of 78 µg/mL and 156 µg/mL, respectively. Additionally, the extract exhibited potent anticancer effects against diverse cancer cell lines of the breast (MCF-7), liver (HepG2), cervix (HeLa), and colon (HCT116) (IC50 for HCT116: 83 ± 2.5, HepG2: 53.3 ± 0.6, MCF-7: 41.5 ± 0.6, and HeLa: 33.3 ± 3.6) by apoptosis after arresting the cells in G1 phase of the cell cycle.
Conclusion: These results suggest that M. communis leaf extract is a potential source of secondary metabolites that could be further developed as potential anti-cancer and anti-mycobacterial agents to treat diverse types of cancers and mycobacterial infections.
In-situ and ex-situ experimental investigation on the chalcopyrite replacement in saline solution at 310–365 °C and 15–25 MPa
Authors: Wang Luying , Li Heping , Liu Qingyou , Lin Sen , Li Shengbin
Published: April 2024

The replacement of chalcopyrite in NaCl solutions was investigated from 310 to 365 °C and 15 to 25 MPa with ex-situ surface characterization techniques and in-situ electrochemical methods. The replacement products and reactions were analyzed ex situ using Raman spectroscopy and a scanning electron microscope (SEM) with an energy-dispersive X-ray spectrometer (EDS). Chalcopyrite dissolution was monitored by open circuit potential (OCP), polarization curves, and electrochemical impedance spectroscopy (EIS). The ex-situ and in-situ measurements show that: (1) elevated temperature and pressure promote the oxidative dissolution of chalcopyrite by different pathways; (2) the altered chalcopyrite surface consists of an outer layer of hematite and an inner layer of covellite; (3) at elevated temperature, removal of more copper from chalcopyrite surface enhances chalcopyrite dissolution, and favors hematite formation over covellite in the alteration rind; and (4) at elevated pressure, more iron ions diffuse through the passive covellite layer by point defects, promoting chalcopyrite replacement by covellite over hematite. This study provides experimental evidence on the replacement of chalcopyrite by covellite, the precipitation of hematite, and the exchange of Fe/Cu ions between chalcopyrite and hydrothermal brine.
Pengalaman Sense of Smell pada Arsitektur Rumah Adat Suku Osing
Authors: Ariyanto Yusuf , Saphira Helen , Santoso Jason , Gwyneth  , Tandiary Albert Jonathan
Published: April 2024

Title: Sense of Smell Experience on Osing Traditional House Architecture
Nusantara architecture results from identical thinking on cultural background and natural conditions that produce physical comfort and atmosphere resulting from the response of human senses, one of which is the sense of smell. The study focuses on the influences or sense of smell responses associated with buildings, such as building materials used, softscape, and hardscape that produce certain scents, especially in Osing Tribe's Indigenous Houses. In line with that, the study identified smells through sensory mapping and the smell intensity influencing the atmosphere by superimposing a Likert scale with a smells wheel from two objects studied, Homestay Bata Merah and Villa SoLong in Banyuwangi. The results of this study found that building elements such as wood, terraces, natural stones, ceramics, paving blocks, and linen are the primary materials that give characteristic aroma, followed by vegetation such as trees that have flowers or sweet-aromatic fruit also dominate, especially in the Homestay Bata Merah. On the other hand, the typical smells are also formed by the influence of geographical conditions and wind movements as the medium of smells material spread, as in Vila SoLong, which has typical ocean smells. The sense of smell experience of traditional house buildings also shapes Nusantara Architecture's identity and improves the comfort of visitors or people active in it.
Redesain Penataan Pohon Pada Rest Area Jalibar Desa Oro Oro Ombo, Kota Batu
Authors: Qolbi Putri Sifaul , Alfian Rizli , Santoso Dian Kartika
Published: April 2024

Title: Redesign of Tree Arrangement in Jalibar Rest Area, Oro Oro Ombo Village, Batu City
The Jalibar Rest Area is one of the tourist support facilities in Oro Oro Ombo Village. However, this rest area does not yet have a good green planning plan, even though one of the supporting comfort areas in the rest area is the proper arrangement of trees. This research identifies existing tree species and analyzes their functions, evaluates tree arrangements, and recommends tree arrangements based on their function and planting location. The research was conducted in the Jalibar Rest Area in Oro Oro Ombo Village, Batu District, Batu City, East Java. The analytical methods used are Key Performance Index (KPI), Comparative Study, and Spatial Mapping. Based on field observations, it is known that the Jalibar Rest Area has 123 trees with 16 types of trees. Based on the evaluation results, it is known that the suitability of the tree's function to its location, namely that the outer zone of the rest area should be planted with shade trees, guides and trees of aesthetic value. The parking zone is planted with trees that function as shade trees, guides and absorb pollutants. As well as service zones planted with trees with the functions of shade, absorbing pollutants and aesthetics. Recommendations for redesigning tree arrangements in the Jalibar Rest Area include adjusting the function of trees in each zone by maintaining appropriate tree species, replacing inappropriate tree species, adding and subtracting trees based on their planting distance.
Güney Azerbaycan’da Bir Adak Ritüeli: Sofra Açma
Authors: Karabudak Gökhan
Published: April 2024

Yeme-içme her ne kadar ilk çağlarda karın doyurmak amacıyla yapılsa da zaman içerisinde yeni formlara kavuşarak kültüre dönüşmüştür. Bu kültür çevresinde insanlar sofra açmayı sosyal statü olarak yahut Tanrı’ya ulaşmada bir araç olarak görmüşlerdir. Bu yüzden en iyi yemekleri veya hayvanları adak olarak sunmuşlardır. Birçok dinde görülen adak, herhangi bir konuda Tanrı’nın yardımını istemek için başvurulan bir uygulama olarak günümüze kadar gelmiştir. Çocuğun olması, hastalıkların giderilmesi, borçlardan kurtulmak, aile saadetinin sağlanması, zorlukların giderilmesi vb. amaçlar ile başvurulan adak; çeşitli hayvanları kurban etmek suretiyle yapıldığı gibi mum dikmek, para vermek veya dağıtmak, Yasin okumak, mevlit okutmak, sofra adağı veya sofra açmak gibi uygulamalarla da yapılmaktadır. Sofra açmak zorlukların ve ihtiyaçların giderilmesi, dileklerin kabul olması durumunda çeşitli yemeklerin ikram edilmesiyle gerçekleştirilen bir adak çeşididir. Bu adak çeşidi birçok Türk topluluğunda yaşandığı gibi İran’ın kuzey ve kuzeybatısında yaşayan Güney Azerbaycan Türkleri arasında da yaşamaya devam etmektedir. Güney Azerbaycan Türkleri ömür boyu pek çok zorluğa maruz kaldıkları için dinî inançlara sığınarak kendi durumlarına ve ihtiyaçlarına çare aramışlardır. Genel olarak On İki İmamlı Şia anlayışına bağlı olduklarından bu anlayışa mensup olan imamların veya onların soyundan gelenlerin yollarını tutarak zorlukların giderilmesi için adak adamışlardır. Bu bağlamda çalışmada Güney Azerbaycan’da yer alan adak sofralarının içerikleri hakkında bilgiler verilerek işlevleri üzerinde durulması amaçlanmıştır. Çalışmada nitel araştırma modellerinden kültür analizi metodu ile incelenmiş; veri toplama aracı olarak da doküman analizinden yararlanılmıştır. Sonuç olarak Güney Azerbaycan’da sofra açmanın bir adak çeşidi olduğu; dileklerin gerçekleştirilmesi, zorlukların ve sıkıntıların giderilmesi için bir pratiğe dönüştüğü tespit edilmiştir.
Görev Odaklı Liderlik Tarzı, Psikolojik Sermaye, İş Tatmini ve Örgütsel Bağlılık Arasındaki İlişkinin İncelenmesi: Kobi’lere Yönelik Bir Uygulama
Authors: Kaplan Merve , Demirağ Bülent
Published: April 2024

Araştırma; görev odaklı liderlik tarzı, psikolojik sermaye, iş tatmini ve örgütsel bağlılık arasındaki ilişkiyi ölçmek amacıyla gerçekleştirilmiştir. Araştırmada Gaziantep ve Şanlıurfa illerinde faaliyet gösteren kolayda örnekleme yöntemiyle belirlenen küçük ve orta ölçekli 425 işletme çalışanına anket çalışması uygulanmıştır. Bu kapsamda görev odaklı liderlik, psikolojik sermaye, iş tatmini ve örgütsel bağlılık arasındaki ilişki “kısmi en küçük kareler” (PLS) ve “yapısal eşitlik modellemesi” (SEM) ile test edilmiştir. Gerçekleştirilen yapısal eşitlik modeli sonuçlarına göre görev odaklı liderlik tarzının psikolojik sermaye ve psikolojik sermayenin alt boyutları olan öz yeterlilik, iyimserlik, umut ve esneklik/dayanıklılık üzerinde pozitif etkisi olduğu sonuçlarına ulaşılmıştır. Araştırmada görev odaklı liderlik tarzının iş tatmini üzerinde pozitif etkiye sahip olduğu sonucuna ulaşılmıştır. Görev odaklı liderlik tarzının örgütsel bağlılık üzerinde pozitif etkisinin olduğu; örgütsel bağlılığın devam, normatif ve duygusal bağlılık alt boyutları üzerinde pozitif etkisinin olduğu; psikolojik sermayenin iş tatmini üzerinde pozitif etkiye sahip olduğu sonucu elde edilmiştir. Bununla birlikte psikolojik sermayenin örgütsel bağlılık üzerinde pozitif etkisinin olduğu ve örgütsel bağlılığın devam, normatif ve duygusal bağlılık alt boyutları üzerinde pozitif etkisinin olduğu; iş tatmininin örgütsel bağlılık üzerinde pozitif etkisinin olduğu ve örgütsel bağlılığın devam, normatif ve duygusal bağlılık alt boyutları üzerinde pozitif etkiye sahip olduğu sonucuna varılmıştır.
Kafe İşletmecilerinin İşgören Motivasyonunun Önemine ve Artırılmasına Yönelik Değerlendirmeleri: Anamur İlçesinde Nitel Bir Uygulama
Authors: Atsan Mustafa
Published: April 2024

Motivasyon kavramı bireyler için önemli bir kavramdır. Çalışan motivasyonu ise hem bireyler hem de işletmelerin sürdürülebilirliği açısından vazgeçilmez unsurlardan birisidir. Özellikle hizmet sektöründe faaliyet gösteren işletmelerde çalışan bireyler yoğun işgücü ve müşteriler ile temasın daha çok olduğu bir sektör olmasından dolayı motivasyona daha çok ihtiyaç duymaktadırlar. Bu noktadan hareketle çalışmanın amacı, hizmet sektöründe yer alan kafe işletmecilerinin çalışan motivasyonunun önemine ve artırılmasına yönelik değerlendirmelerini ortaya koymaktır. Çalışma, Anamur ilçesinde bulunan ve en çok tercih edilen 5 kafe işletmesinin işletmecilerine nitel araştırma yöntemlerinden olan görüşme tekniği uygulanarak gerçekleştirilmiştir. Araştırmada nitel araştırma türlerinden olan fenomenolojik desen tercih edilmiştir. Veriler içerik analizi yöntemi ile analiz edilmiştir. Analizin ardından varılan sonuçlara göre, kafe işletmecilerinin işgörenlerinin motivasyonlarına önem verdikleri, motivasyon kavramının ve öneminin bilincinde oldukları, işgörenlerinin motivasyonlarının artırılmasına yönelik motivasyon tekniklerini kullandıkları saptanmıştır. Ayrıca araştırmanın ulaşılan bulgularında katılımcıların vermiş oldukları cevaplarda kafe çalışanlarının, literatürde yer alan bazı motivasyon yöntemlerini kullanmadıkları görülmüştür. Bunun nedeni olarak ise kafede çalışan bireylerin daha çok öğrenci olması ve hedeflerinin, beklentilerinin farklılık göstermesinden ötürü bu yöntemleri kullanmadıkları düşünülmektedir. Bu bağlamda katılımcıların vermiş oldukları cevaplar ile ulaşılan bulguların literatürde bahsedilen önem ve yöntemleri desteklediği görülmüştür. Ayrıca çalışmanın bulgularının kafe işletmecileri ile paylaşılacak olmasından ötürü, sonuç kısmında işletmeciler için motivasyonu artırmaya yönelik farklı yöntem önerileri sunulmuştur.
Bereavement And Melancholy in Cinema: A Comparative Review Between Turkish and American Cinemas
Authors: Özkantar Mustafa Özer
Published: April 2024

Cinema is one of the most vivid and sensational reflection tools in the art world since it reverberates almost all emotions concerning human beings and their experiences. One of these emotions is grief due to the loss of our beloved ones and in the same way as existence and life, it is a striking issue covering lots of films and thus the concept of mourning and sorrow are the most outstanding and common themes having a profound impact on cinema audiences. In other words, despite cultural and social differences all around the world, grief and pain are intense and universal emotions. Understanding and interpreting the contexts in which these emotions are addressed in different cinema cultures is essential to reveal the cultural projections of cinematic narratives. As part of this idea, the main purpose of this study is to illustrate how Turkish Cinema and American Cinema approach the concepts of bereavement and lament. Accordingly, four well-known films, Canım Kardeşim (1973) Babam ve Oğlum (2005), Rabbit Hole (2010) and finally Manchester by the Sea (2016) have been determined via purposeful sampling method and analyzed by focusing on remarkable similarities and differences in terms of loss and death with the aid of descriptive analysis. As a result of reviews of the films, it has been observed that the Turkish approach to death and loss includes melodrama, emotional abuse, and local connotations while the American one involves a more realistic point of view underlying individual crises, mental collapses or devastations.
Ayıntâblı Şâkir Divanı’nda Hikemî Üslup
Authors: Açar Zeliha
Published: April 2024

Hikmet, en genel tanımıyla bir milletin düşünce sistemi ve dünya görüşüdür. Hikmet bu yönüyle hem yaratılış gibi fizik ötesi konuları hem de toplumsal hayatı belirleyen hususlarla olan ilişkisinden dolayı ahlak ile de bağdaştırılmaktadır. Teokratik toplumlarda dünya görüşünün esası din olduğundan hikmet, dinle de alakalıdır. Hikmet ihtiva eden hakimane şiir ise bu gibi düşüncelere ağırlık veren, muhatabını uyarıp aydınlatmak gayesini güden didaktik şiirlerdir. Türk edebiyatının başlangıç dönemlerinden itibaren görülmeye başlanan şiire hikmet yerleştirme, klasik şiirle birlikte yaygınlaşmış, Nâbî’nin kaleminde kemal derecesine ulaşmıştır. Umumiyetle klasik şiirin son dönemlerinde hem devletin çökmeye başlaması hem de yönün artık doğuya değil de batıya dönülmüş olmasıyla sosyal hayattaki yozlaşmaların arttığı düşünülmüş, bunun neticesi olarak toplumsal hayattaki aksamalar şiirlere çokça konu edilmeye başlamıştır. Âlim bir şeyh olan Ayıntâblı Muhammed Şâkir Efendi de klasik şiirin son döneminde yetişmiş birçok şair gibi Nâbî’nin de etkisinde kalarak didaktik şiirler yazmıştır. Ayıntâblı Şâkir, divanında sosyal hayattaki bozulmalar ve toplumun hayat anlayışını belirleyen hususlarla ilgili ahlak yapısındaki yozlaşmalardan yakınıp, şiirlerini muhataplarını eğitmek üzere kaleme alan şairlerin müşterek üslubu olan hikemî üsluba yoğun olarak müracaat etmiştir. Mutasavvıf olan şair, divanı boyunca dinin emir ve yasaklarını belirgin bir şekilde ifade etmiştir. Şairin dili, bu yönüyle sade ve anlaşılırdır. Bu çalışmada XIX. yüzyıl taşra şairlerinden olan Ayıntâblı Şâkir Divanı’nda Nâbî etkisi tespit edilip hakimane söylemler ortaya konmaya çalışılacaktır.
Kemalist Köycülük Politikaları Doğrultusunda Köy Enstitüleri
Authors: Coşkuner Evrim Armağan
Published: April 2024

Ulus devlet inşasında Kemalist kurucu kadronun seçkinleri, yapılan reformların kırsal kesime yeterince ulaşamadığının farkına varmıştır. Bunun yanında kırsal kesimin ekonomik, tarımsal ve kültürel yönden geliştirilmesinin gerekliliği, yöneticiler tarafından büyük bir mesele olarak görülmüştür. Bu dönemde ülke nüfusunun büyük bölümü kırsal kesimde yaşamaktadır. Kırsal kesimde yaşayan halk da ekonomik yönden yoksuldur. Bu sebepler dolayısıyla Kemalist yönetim için kırsal kesimin eğitilmesi meselesi 1930’lu yıllarda hız kazanmasına rağmen bu durum büyük oranda 1940’lı yıllarda açılan Köy Enstitüleri sayesinde mümkün olmuştur. Enstitüler kırsal kesime hem Kemalist modernleşmeyi ulaştırma amacı gütmüş hem de kırsal kesimi ekonomik, tarımsal ve kültürel yönden geliştirmeyi amaçlamıştır. Enstitüler sayesinde gelişen köy ve kırsal kesimin, aynı zamanda ülkenin ekonomik durumuna da katkı sağlaması planlanmıştır. Kemalist yönetim Köy Enstitüleri ile istediği sonucu 1940’lı yıllar boyunca elde etmeye başlamış ve bu konuda da büyük oranda başarılı olmuştur. Fakat II. Dünya Savaşı sonrası Türkiye’de çok partili hayata geçilmesi ile oluşan siyasal çekişmeler gibi etkenler dolayısıyla Köy Enstitüleri, 1950’li yılların başlarında yeterince sahip çıkılmayarak kapatılmıştır. Kapatılmalarının ardından Köy Enstitüleri bugün bile gündemden düşmeyen bir mesele olmuştur. Bu makale, Kemalist elitlerin yapılan devrimlerin özünü halka ulaştırma ve kırsal kesimi geliştirme konusunda köycülük çalışmalarına, ayrıca bu konuda Köy Enstitülerinin rolüne odaklanmaktadır. Bunun yanında makalede Köy Enstitülerine yapılan eleştiriler, bu eleştirilere verilen cevaplar ve Enstitülerin kapatılma sürecine ilişkin Türkiye Büyük Millet Meclisi’nin gündemini meşgul eden konular ayrıntılı bir şekilde ele alınmıştır. Makalede, Köy Enstitülerinin kuruluşu ve kurulduktan sonraki işlevi ile nasıl kapatıldıklarına dair bilgiler mevcuttur.
Van Ağzı Deyimleri
Authors: Akman Hami
Published: April 2024

Deyim; genellikle en az iki kelimeden oluşan, gerçek anlamından az ya da çok uzaklaşıp mecaz bir anlam kazanmış, anlatıma canlılık, renk ve heyecan katan kalıplaşmış söz dizileri olarak tanımlanabilir. Deyimin kalıplaşma özelliği, onun uzun süre değişmeden günümüze kadar ulaşmasını da beraberinde getirmiştir. Bu özelliği deyimi, dil açısından ele alınıp incelenmesi noktasında çekici bir hâle getirmiştir. Türkçe ilk kullanıldığı dönemlerden itibaren zengin bir deyim varlığına sahip olmuştur. Bu zenginlik, Türkçenin sadece yazı dillerinde değil; aynı zamanda bu yazı dillerine mensup olan ağızlarında da kendisini göstermiştir. Ağızlarda kullanılan deyimler üzerine yapılan çalışmaların sayısı son zamanlarda artmıştır. Bu çalışmada da Van ağzındaki deyimler ele alınmıştır. Van ağzı Türkiye’deki ağız sınıflandırmalarında Doğu Grubu Ağızları arasında ele alınmaktadır. Söz konusu ağız özellikle deyim varlığındaki zenginliğiyle dikkat çekicidir. Bu deyimler, birçok kavramın ifadesinde rol oynamaktadır. Bu kavramlardan bazıları; fiziki özellikler, öfke, sinir, evlilik, yeme içme, yalan, iftira, nazlanma, hoşnutsuzluk, kaybetme, defolma, küfür, hakaret etme, özür ve af dileme, dile düşme, maruz kalma, tecrübe-tecrübesizlik, deneyim-deneyimsizlik, acelecilik, merak etme, oyun, zulüm, eziyet, kurtarma, kurtulma, kurtarılma, emek, çaba, zorluk ya da mesele çıkarma, cesaret, ileri gitme, ısrar, inat, yarar, fayda, yemin, hayal/tasavvur etme, kötü bakış, rahatsızlık, hâkim olma, hava durumu, hak, Kur’an, yorgunluk, bitkinlik, çiş, işeme, ölüm, katletme, iyilik, komşuluk, cehalet, namaz, nazar, sınır, karşılık, mukabeledir. Bu makale bir ağız, dolayısıyla derleme çalışmasıdır. Derlemede görüşülen ve veriler toplanan kaynak kişilerin bilgileri çalışmanın sonunda listelenmiştir. Çalışmanın, ağızlar özelinde Türk diline katkı sağlaması umulmaktadır.