bluuebunny/crossref_metadata_2025 huggingface dataset:
Metabolome patterns identify active dechlorination in bioaugmentation consortium SDC-9™
Authors: May Amanda L. , Xie Yongchao , Kara Murdoch Fadime , Michalsen Mandy M. , Löffler Frank E. , Campagna Shawn R.
Published: October 2022

Ultra-high performance liquid chromatography–high-resolution mass spectrometry (UPHLC–HRMS) is used to discover and monitor single or sets of biomarkers informing about metabolic processes of interest. The technique can detect 1000’s of molecules (i.e., metabolites) in a single instrument run and provide a measurement of the global metabolome, which could be a fingerprint of activity. Despite the power of this approach, technical challenges have hindered the effective use of metabolomics to interrogate microbial communities implicated in the removal of priority contaminants. Herein, our efforts to circumvent these challenges and apply this emerging systems biology technique to microbiomes relevant for contaminant biodegradation will be discussed. Chlorinated ethenes impact many contaminated sites, and detoxification can be achieved by organohalide-respiring bacteria, a process currently assessed by quantitative gene-centric tools (e.g., quantitative PCR). This laboratory study monitored the metabolome of the SDC-9™ bioaugmentation consortium during cis-1,2-dichloroethene (cDCE) conversion to vinyl chloride (VC) and nontoxic ethene. Untargeted metabolomics using an UHPLC-Orbitrap mass spectrometer and performed on SDC-9™ cultures at different stages of the reductive dechlorination process detected ~10,000 spectral features per sample arising from water-soluble molecules with both known and unknown structures. Multivariate statistical techniques including partial least squares-discriminate analysis (PLSDA) identified patterns of measurable spectral features (peak patterns) that correlated with dechlorination (in)activity, and ANOVA analyses identified 18 potential biomarkers for this process. Statistical clustering of samples with these 18 features identified dechlorination activity more reliably than clustering of samples based only on chlorinated ethene concentration and Dhc 16S rRNA gene abundance data, highlighting the potential value of metabolomic workflows as an innovative site assessment and bioremediation monitoring tool.
Morphometric similarity networks discriminate patients with lumbar disc herniation from healthy controls and predict pain intensity
Authors: Yang Lili , Vigotsky Andrew D. , Wu Binbin , Shen Bangli , Yan Zhihan , Apkarian A. Vania , Huang Lejian
Published: October 2022

We used a recently advanced technique, morphometric similarity (MS), in a large sample of lumbar disc herniation patients with chronic pain (LDH-CP) to examine morphometric features derived from multimodal MRI data. To do so, we evenly allocated 136 LDH-CPs to exploratory and validation groups with matched healthy controls (HC), randomly chosen from the pool of 157 HCs. We developed three MS-based models to discriminate LDH-CPs from HCs and to predict the pain intensity of LDH-CPs. In addition, we created analogous models using resting state functional connectivity (FC) to perform the above discrimination and prediction of pain, in addition to comparing the performance of FC- and MS-based models and investigating if an ensemble model, combining morphometric features and resting-state signals, could improve performance. We conclude that 1) MS-based models were able to discriminate LDH-CPs from HCs and the MS networks (MSN) model performed best; 2) MSN was able to predict the pain intensity of LDH-CPs; 3) FC networks constructed were able to discriminate LDH-CPs from HCs, but they could not predict pain intensity; and 4) the ensemble model neither improved discrimination nor pain prediction performance. Generally, MSN is sensitive enough to uncover brain morphology alterations associated with chronic pain and provides novel insights regarding the neuropathology of chronic pain.
Posture dependent factors influence movement variability when reaching to nearby virtual objects
Authors: Phataraphruk Preyaporn , Rahman Qasim , Lakshminarayanan Kishor , Fruchtman Mitchell , Buneo Christopher A.
Published: October 2022

Reaching movements are subject to noise arising during the sensing, planning and execution phases of movement production, which contributes to movement variability. When vision of the moving hand is available, reach endpoint variability appears to be strongly influenced by internal noise associated with the specification and/or online updating of movement plans in visual coordinates. In contrast, without hand vision, endpoint variability appears more dependent upon movement direction, suggesting a greater influence of execution noise. Given that execution noise acts in part at the muscular level, we hypothesized that reaching variability should depend not only on movement direction but initial arm posture as well. Moreover, given that the effects of execution noise are more apparent when hand vision is unavailable, we reasoned that postural effects would be more evident when visual feedback was withheld. To test these hypotheses, participants planned memory-guided reaching movements to three frontal plane targets using one of two initial arm postures (“adducted” or “abducted”), attained by rotating the arm about the shoulder-hand axis. In this way, variability was examined for two sets of movements that were largely identical in endpoint coordinates but different in joint/muscle-based coordinates. We found that patterns of reaching variability differed in several respects when movements were initiated with different arm postures. These postural effects were evident shortly after movement onset, near the midpoints of the movements, and again at the endpoints. At the endpoints, posture dependent effects interacted with effects of visual feedback to determine some aspects of variability. These results suggest that posture dependent execution noise interacts with feedback control mechanisms and biomechanical factors to determine patterns of reach endpoint variability in 3D space.
The effects of supplementation of probiotics, prebiotics, or synbiotics on patients with non-alcoholic fatty liver disease: A meta-analysis of randomized controlled trials
Authors: Xing Wenmin , Gao Wenyan , Lv Xiaoling , Zhao Zhenlei , Mao Genxiang , Dong Xiaoyan , Zhang Zuyong
Published: October 2022

Background

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease. Research on the efficacy of probiotics, prebiotics, and synbiotics on NAFLD patients continues to be inconsistent. The purpose of this study is to evaluate the effectiveness of these microbial therapies on NAFLD.

Methods

Eligible randomized-controlled trials reporting the effect of probiotics, prebiotics, or synbiotics in NAFLD were searched in PubMed, Web of Science, Embase, Google scholar, and CNKI databases from 2020 to Jul 2022. The changes in the outcomes were analyzed using standard mean difference (SMD) and 95% confidence intervals (CIs) with a random- or fixed-effects model to examine the effect of microbial therapies. Subgroup analysis, influence and publication bias analysis were also performed. The quality of the eligible studies was evaluated using the Cochrane Risk of Bias Tool.

Results

Eleven studies met the inclusion criteria involving 741 individuals. Microbial therapies could improve liver steatosis, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-c), alanine aminotransferase (ALT), alkaline phosphatase (ALP), glutamyl transpeptidase (GGT), and homeostasis model assessment-insulin resistance (HOMAI-R) (all P < 0.05). But microbial therapies could not ameliorate body mass index (BMI), energy, carbohydrate, fat intake, fasting blood sugar, HbA1c, insulin, high-sensitivity C-reactive protein (hs-CRP), and hepatic fibrosis of patients with NAFLD.

Conclusion

Probiotics, prebiotics, and synbiotics supplementation can potentially improve liver enzymes, lipid profiles, and liver steatosis in patients with NAFLD.
Pure laparoscopic radical nephroureterectomy for complicated renal pelvis carcinoma combined with horseshoe kidney: A case report and literature review
Authors: Huang Ruizhen , Tian Jie , Jiang Weifan
Published: October 2022

We reported a case of pure laparoscopic radical nephroureterectomy for complicated renal pelvis carcinoma combined with horseshoe kidney (HSK). The aim was to present a case report and review of the literature about renal pelvis carcinoma combined with HSK. The case report includes a history of patient data. The pure laparoscopic radical nephroureterectomy was provided with the informed consent of the patient. A 53-year-old patient was diagnosed with a right renal pelvis mass with HSK. We performed laparoscopic radical nephroureterectomy with partial cystectomy and horseshoe renal isthmus amputation. Histopathological features, computed tomography urography (CTU), and angiography (CTA) confirmed the diagnosis of renal pelvis carcinoma combined with HSK. The tumor was removed, and the patient had an uneventful recovery. Renal pelvis carcinoma combined with HSK is a rare case. Due to severe anatomical abnormalities, this disease is a major challenge for urologists. We share our successful case for readers to learn from.
Risk of adenoma recurrence after polypectomy in patients younger than 50 years vs. 50 years old and over with diminutive or small adenomas
Authors: Cai Sicheng , Shi Huiying , Fan Mengke , Zhang Qin , Lin Rong
Published: October 2022

Background and aims

Current studies have shown that polyp recurrence occurs after colonic adenomas polypectomy (AP), but the difference in recurrence risk between patients in patients older than 50 years and younger than 50 years has not been clearly studied.

Methods

490 patients after AP were enrolled in the study. The patients were classified according to age (<50 years old or ≥50 years old), and then further categorized according to the baseline adenoma characteristics: Group 1: 1–2 non-advanced adenomas (NAAs) 1–5 mm in size; Group 2: ≥3 NAAs, 1–5 mm; Group 3: 1–2 NAAs, 6–9 mm; Group 4: ≥3 NAAs, 6–9 mm; and Group 5: advanced adenomas.

Results

During a mean follow-up interval of 2.52 years (2.51 years for ≥50 years old and 2.55 years for patients <50 years old), NAA recurrence was detected in 147 patients (30.0%). Overall, the hazard ratio (HR) for NAA recurrence after AP was higher in patients ≥50 years old than that in patients <50 years old (HR, 1.774, P = 0.003). For patients <50 years old, HRs (Group 2-5 vs. G1, respectively) for NAA recurrence were 0.744 (P = 0.773), 3.885 (P = 0.007), 5.337 (P = 0.003), and 3.334 (P = 0.015). For patients ≥50 years old, HRs (Group 2-5 vs. G1, respectively) for NAA recurrence were 1.033 (P = 0.965), 1.250 (P = 0.405), 2.252 (P = 0.015), and 1.887 (P = 0.009). For G1, the risk of NAA recurrence was significantly higher in patients ≥50 years old (HR, 2.932, P = 0.011) than that in patients <50 years old; for G2–G5, the risk was similar in the two age groups (P > 0.05).

Conclusions

For patients <50 years old with less than 3 NAAs that are 1–5 mm in size, the recurrence rate of NAA is less than that of patients ≥50 years old with the same index colonoscopy findings. When the adenomas are ≥5 mm, or their number exceeds 3, they have similar recurrence risk as that for patients ≥50 years old.
Predictive value of C-reactive protein levels for the early and later detection of postoperative complications after cytoreductive surgery and HIPEC
Authors: Roux Alexia , David Valentin , Bardet M Sylvia , Auditeau Emilie , Durand Fontanier Sylvaine , Taibi Abdelkader
Published: October 2022

Synopsis

C-reactive protein (CRP), white blood cells and procalcitonin (PCT) participate in the systemic response to inflammation and increase after postoperative infective complications. Postoperative complications after CRS and HIPEC could be predicted using the CRP cut-off value (169 mg/L at PODs 3-5 and 62 mg/L at PODs 7-10).

Background

Postoperative elevation of C-reactive protein (CRP) can be used in order to predict the postoperative complications in many indications. Cytoreduction surgery (CRS) associated with hyperthermic intraperitoneal chemotherapy (HIPEC) is associated with high morbidity.

Objectives

The aim of the study was to demonstrate the CRP predictive value for the occurrence of complications.

Methods

All patients who had CRS and HIPEC, regardless of the origin of peritoneal metastasis, were included in this retrospective study. Postoperative complications and CRP and white blood cell (WBC) counts were recorded from postoperative day (POD) 1 through 10.

Results

Among the 127 patients included, 58 (45.7%) had no complications (NCs), 53 (41.7%) had infective complications (ICs), and 16 (12.6%) had non-infective complications (NICs). The IC group had a higher CRP value than the NC group, which was statistically significant from POD7 to POD10 (41.1 versus 107.5 p = 0.023 and 77.8 versus 140 p = 0.047, respectively). A cut-off CRP value was 169 mg/L at PODs 3-5 and 62 mg/L at PODs 7-10. The area under the curve (AUC) at POD5 was 0.56 versus 0.76 at POD7, p=0.007. The sensibility, specificity, positive and negative predictive values of these cut-offs were 55%, 83%, 74% and 67%, respectively. Moreover, 17 patients (32%) with ICs had a CRP value higher than these cut-offs before the diagnosis was made by the medical team.

Conclusion

This study suggested that postoperative complications could be predicted using the CRP cut-off value on PODs 3-5 (169 mg/l) and PODs 7-10 (62 mg/l) after CRS and HIPEC.
Three-dimensional ultrasound integrating nomogram and the blood flow image for prostate cancer diagnosis and biopsy: A retrospective study
Authors: Chen Dong , Niu Yingjie , Chen Haitao , Liu Dequan , Guo Rong , Yao Nan , Li Zhiyao , Luo Xiaomao , Li Hongyang , Tang Shicong
Published: October 2022

Backgrounds

Prostate cancer (PCa) is the second most common male cancer in the world and based on its high prevalence and overwhelming effect on patients, more precise diagnostic and therapeutic methods are essential research topics. As such, this study aims to evaluate the value of three-dimensional transrectal ultrasound (3D-TRUS) in the detection, diagnosis and biopsy of PCa, and to provide a basis for clinical practice of PCa.

Methods

Retrospective analysis and comparison of a total of 401 male patients who underwent prostate TRUS in our hospital from 2019 to 2020 were conducted, with all patients having prostate biopsy. Nomogram was used to estimate the probability of different ultrasound signs in diagnosing prostate cancer. The ROC curve was used to estimate the screening and diagnosis rates of 3D-TRUS, MRI and TRUS for prostate cancer.

Results

A total of 401 patients were randomly divided into two groups according to different methods of prostate ultrasonography, namely the TRUS group (251 patients) and the 3D-TRUS group (150 patients). Of these cases, 111 patients in 3D-TRUS group underwent MRI scan. The nomogram further determined the value of 3D-TRUS for prostate cancer. The ROC AUC of prostate cancer detected by TRUS, MRI and 3D-TRUS was 0.5580, 0.6216 and 0.6267 respectively. Biopsy complications were lower in 3D-TRUS group than TRUS group, which was statistically significant (P<0.005).

Conclusions

The accuracy of 3D-TRUS was higher in diagnosis and biopsy of prostate cancer. Meanwhile, the positive rate of biopsy could be improved under direct visualization of 3D-TRUS, and the complications could be decreased markedly. Therefore, 3D-TRUS was of high clinical value in diagnosis and biopsy of prostate cancer.
Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis
Authors: Guo Keke , Liu Run , Jing Rongrong , Wang Lusheng , Li Xuenan , Zhang Kaini , Fu Mengli , Ye Jiabin , Hu Zhenlin , Zhao Wengang , Xu Nuo
Published: October 2022

The integrity of skin tissue structure and function plays an important role in maintaining skin rejuvenation. Ultraviolet (UV) radiation is the main environmental factor that causes skin aging through photodamage of the skin tissue. Cryptotanshinone (CTS), an active ingredient mianly derived from the Salvia plants of Lamiaceae, has many pharmacological effects, such as anti-inflammatory, antioxidant, and anti-tumor effects. In this study, we showed that CTS could ameliorate the photodamage induced by UV radiation in epidermal keratinocytes (HaCaT) and dermal fibroblasts (HFF-1) when applied to the cells before exposure to the radiation, effectively delaying the aging of the cells. CTS exerted its antiaging effect by reducing the level of reactive oxygen species (ROS) in the cells, attenuating DNA damage, activating the nuclear factor E2-related factor 2 (Nrf2) signaling pathway, and reduced mitochondrial dysfunction as well as inhibiting apoptosis. Further, CTS could promote mitochondrial biosynthesis in skin cells by activating the AMP-activated protein kinase (AMPK)/sirtuin-1 (SIRT1)/peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) signaling pathway. These findings demonstrated the protective effects of CTS against UV radiation-induced skin photoaging and provided a theoretical and experimental basis for the application of CTS as an anti-photodamage and anti-aging agent for the skin.
Acquired lymphedema: Molecular contributors and future directions for developing intervention strategies
Authors: Nurlaila Ika , Roh Kangsan , Yeom Chang-Hwan , Kang Hee , Lee Sukchan
Published: October 2022

Lymphedema is a debilitating chronic disease that mostly develops as an adverse reaction to cancer treatment modalities such as chemotherapy, surgery, and radiotherapy. Lymphedema also appears to be a deteriorating consequence of roundworm infections, as best represented by filariasis. According to its origin, lymphedema is classified as primary lymphedema and acquired lymphedema. The latter is an acquired condition that, hitherto, received a considerably low attention owing to the less number of fatal cases been reported. Notably, despite the low mortality rate in lymphedema, it has been widely reported to reduce the disease-free survival and thus the quality of life of affected patients. Hence, in this review, we focused on acquired lymphedema and orchestration of molecular interplays associated with either stimulation or inhibition of lymphedema development that were, in vast majority, clearly depicted in animal models with their specific and distinct technical approaches. We also discussed some recent progress made in phytochemical-based anti-lymphedema intervention strategies and the specific mechanisms underlying their anti-lymphedema properties. This review is crucial to understand not only the comprehensive aspects of the disease but also the future directions of the intervention strategies that can address the quality of life of affected patients rather than alleviating apparent symptoms only.
The effect of information overload and perceived risk on tourists’ intention to travel in the post-COVID-19 pandemic
Authors: Wu Hong , Cao Qi , Mao Jia-Min , Hu Hui-Ling
Published: October 2022

Since the COVID-19 pandemic, the tourism economy has been seriously affected. China has implemented a direct traveling management mechanism and recovered from the pandemic faster than the rest of the world. However, the COVID-19 situation is complicated and uncontrollable because of the available unclear information including difficult medical terminologies. This study attempts to find the determinants of the travel intention of China’s tourists in the post-COVID-19 epidemic. Along with information overload and perception risk, an expanded research model of the Theory of Planned Behavior (TPB) was employed to propose the theoretical framework of this study. A survey was conducted among 518 tourists who spend their holiday in Hainan, which is a popular tourist destination in China. The empirical results show that information overload positively and significantly impacted perceived risk. Furthermore, perceived risk negatively affects the intention to travel. Perceived risk also negatively affected the attitude toward traveling. However, response self-efficacy did not have a significant effect on the intention to travel. Finally, based on the analysis results, this study proposes relevant research contributions and practical recommendations with management implications for the travel industries.
Pleasure of paying when using mobile payment: Evidence from EEG studies
Authors: Wang Manlin , Ling Aiqing , He Yijin , Tan Yulin , Zhang Linanzi , Chang Zeyu , Ma Qingguo
Published: October 2022

Mobile payment has emerged as a popular payment method in many countries. While much research has focused on the antecedents of mobile payment adoption, limited research has investigated the consequences of mobile payment usage relating to how it would influence consumer behaviors (e.g., purchase intention or willingness to pay). Here, we propose that mobile payment not just reduces the “pain of paying,” a traditional view explaining why cashless payment stimulates spending, but it also evokes the “pleasure of paying,” raising from the enhanced processing fluency in completing transactions. We tested this new conceptualization of “pleasure of paying” using EEG, complementing other behavioral measures. In two studies, we found that mobile payment effectively enhanced purchase likelihood (study 1, N = 66) and such an enhancement is generalizable to both hedonic and utilitarian products (study 2, N = 29). By employing EEG measures, we provided the first neural evidence of “pleasure of paying” in addition to the signal of “pain of paying.” Critically, we demonstrated that the “pleasure of paying” is a distinctive psychological mechanism that is induced by mobile payment usage and that the “pleasure of paying” joins the “pain of paying” to mediate the increased purchase intention. We discuss the contributions and implications of these results to the ongoing evolution of cashless payment societies.
Motivational profiles of kindergarten teachers in minority areas of China and their association with outcomes
Authors: Shi Dasheng , Zhang Mengmeng , Chen Ye , Jin Ruining , Yang Xiantong
Published: October 2022

Academic discourses regarding teacher motivation have been on-going for decades for those who teach in ethnic minority areas. Yet research findings failed to provide a consistent conclusion regarding if kindergarten teachers’ motivation pattern would vary based on a case-to-case scenario. Therefore, further studies are needed to probe the motivation patterns among this population. The study firstly examined kindergarten teachers’ motivational profiles based on Expectancy Value Theory (EVT), and then examined how teachers’ motivation related to outcome variables (work engagement, workplace wellbeing, and retention intention). Participants included 1,199 kindergarten teachers from ethnic minority areas in China. Latent profile analysis identified three motivation profiles for teachers: low value-high cost (profile 1), moderate all (profile 2), and high value-low cost (profile 3). Teacher with different motivation profiles had significant differences in work engagement, workplace wellbeing, and retention intention. In addition, chain mediation analysis revealed that work engagement and workplace wellbeing mediated the relationship between motivation profiles and retention intention. The implications of the findings for study are discussed.
How does social support influence tourist-oriented citizenship behavior? A self-determination theory perspective
Authors: Li Ruyou , Shi Zhangyu
Published: October 2022

As a driver of tourist-oriented citizenship behavior (TOCB), the effect of social support has not been thoroughly investigated. Grounded in a framework integrating the stimulus-organism-response model and self-determination theory, this study investigates how social support influences TOCB through the sense of self-determination. Structural equation modeling is used to analyze the survey data collected from 377 tourists in China. It is found that social support (information and emotional support) have a remarkably positive impact on the sense of self-determination (perceived autonomy, competence, and relatedness) which have an intermediary role in the relationship between social support and TOCB. This study provides empirical evidence for the marketing strategies of tourism destinations and enterprises.
The moderating effect of alexithymia on the relationship between stress and cyberchondria
Authors: Zhou Yi , Dai Lisha , Deng Yunlong , Zeng Hongling , Yang Lifeng
Published: October 2022

Objectives

The pandemic has increased the level of perceived stress and provided a fertile soil for Cyberchondria. This study aims to investigate the relationship between stress, cyberchondria, and alexithymia.

Methods

This cross-sectional study used convenience sampling to carried out on a total 1,117 college students (female/male:536/581; mean age: 19.95 ± 1.32). Cyberchondria Severity Scale (CSS), Toronto Alexithymia Scale (TAS) and Short Depression Anxiety Stress Scales (DASS-21) were used to assessed the present study variables.

Results

Significant differences emerged for CSS scores by gender (t = 3.74, p < 0.01) and had any comorbid disease (t = 2.47, p < 0.05), The Pearson correlation showed Cyberchondria has a significant positive correlation with stress and alexithymia (r = 0.50, p < 0.01, r = 0.36, p < 0.01). Furthermore, the regression analysis described that stress (β = 0.50, p < 0.01) and alexithymia (β = 0.36, p < 0.01) were the significant positive predictors of cyberchondria. Moreover, moderation analysis showed that alexithymia significantly strengthened the association between stress and cyberchondria (F = 107.20, p < 0.01).

Conclusion

The study will help medical practitioners to understand how stress and alexithymia can cause an increase in cyberchondria. This will help them to elaborate operational indications for prevention and psychological support.
Cyberbullying definitions and measurements in children and adolescents: Summarizing 20 years of global efforts
Authors: Zhang Wei , Huang Shiqing , Lam Lawrence , Evans Richard , Zhu Chengyan
Published: October 2022

Despite numerous instruments existing to assist in the measurement of specific cyberbullying behaviors or cyberbullying in general, it is still unclear their purpose, corresponding scenarios, and their effectiveness. This study, therefore, aims to provide a comprehensive review of academic efforts on cyberbullying definitions, measurements, and their effectiveness in children and adolescents in the past two decades. A systematic review was performed using ASReview, an open source machine learning systematic review system. Three bibliographic citation databases, including Web of Science core collection, PubMed, and EBSCO were adopted for all relevant literature published from January 2001 to August 2021. In total, twenty-five studies, mentioning seventeen cyberbullying measurement scales, met the study collection criteria. The results found that most failed to provide a clear definition of cyberbullying, often providing unclear and inconsistent descriptions for the youth. Similarly, studies found it difficult to clearly reflect the three key elements of bullying, namely: harmfulness, repetitiveness, and the power imbalance between bullies and victims. With regard to cyberbullying types, most presented two or three categories, including victimization, perpetration, and bystanding, while some suggested four types based on the nature of the cyberbullying behavior, including written or verbal, visual or sexual, character impersonation, and exclusion. If characteristics are considered, cyberbullying becomes more specific with multiple categories being proposed, including flaming (or roasting), harassment, denigration, defamation, outing, jokes, online sexual harassment, and cyberstalking. With regard to measurements, many scales have been proposed and frequently refined to capture specific cyberbullying experience of the youth. This study emphasizes the value and importance of providing clear cyberbullying definitions and helps scholars in youth cyberbullying choose appropriate measurement scales.
A school of public health responds to the pandemic: A case study from Washington D.C.
Authors: Hyder Adnan A. , Thorpe Jane H. , Migliaccio Eugene , Kazeem Natasha , Goldman Lynn R.
Published: October 2022

The emergence of COVID-19 immediately affected higher education, and the closure of campuses at the start of the pandemic in March of 2020 forced educational institutions to quickly adapt to changing circumstances. Schools of public health faced challenges not only of shifting to remote learning and work environments, but also uniquely redirecting public health research and service efforts toward COVID-19. This paper offers a case study of how the Milken Institute School of Public Health at the George Washington University (GWSPH), the only school of public health in the nation's capital, initially adapted to the COVID-19 pandemic. Using a modified version of the Public Health Preparedness and Response Core Competency Model created by the Association of Schools and Programs of Public Health and the Centers for Disease Control and Prevention, we analyze how GWSPH worked in three areas—research, education, service/operations. We reviewed this initial response across four domains: model leadership; communication and management of information; planning and improving practice; and protecting worker (and student) health and safety. The adaptation of the model and the analysis of GWSPH's initial response to the pandemic can be useful to other schools of public health and health sciences in the United States and beyond, in preparing for all hazards. We hope that such analysis also informs the current concerns of schools such as return to in-person education as well as planning for future public health crises.
Religious affiliation as a driver of immunization coverage: Analyses of zero-dose vaccine prevalence in 66 low- and middle-income countries
Authors: Santos Thiago M. , Cata-Preta Bianca O. , Wendt Andrea , Arroyave Luisa , Hogan Daniel R. , Mengistu Tewodaj , Barros Aluisio J. D. , Victora Cesar G.
Published: October 2022

Background

The literature on the association between religion and immunization coverage is scant, mostly consisting of single-country studies. Analyses in low and middle-income countries (LMICs) to assess whether the proportions of zero-dose children vary according to religion remains necessary to better understand non-socioeconomic immunization barriers and to inform interventions that target zero-dose children.

Methods

We included 66 LMICs with standardized national surveys carried out since 2010, with information on religion and vaccination. The proportion of children who failed to receive any doses of a diphtheria-pertussis-tetanus (DPT) containing vaccine – a proxy for no access to routine vaccination or “zero-dose” status – was the outcome. Differences among religious groups were assessed using a test for heterogeneity. Additional analyses were performed controlling for the fixed effect of country, household wealth, maternal education, and urban-rural residence to assess associations between religion and immunization.

Findings

In 27 countries there was significant heterogeneity in no-DPT prevalence according to religion. Pooled analyses adjusted for wealth, maternal education, and area of residence showed that Muslim children had 76% higher no-DPT prevalence than Christian children. Children from the majority religion in each country tended to have lower no-DPT prevalence than the rest of the population except in Muslim-majority countries.

Interpretation

Analyses of gaps in coverage according to religion are relevant to renewing efforts to reach groups that are being left behind, with an important role in the reduction of zero-dose children.
Rapid qualitative analysis in a mixed-methods evaluation of an infection prevention intervention in a UK hospital setting during the COVID-19 pandemic: A discussion of the CLEAN study methodology
Authors: Higham Ruchi , Pini Simon , Quyn Aaron , Kowal Mikolaj , Helliwell Jack , Saman Razan , Lewthwaite Penny , Young Nicola , Rousseau Nikki
Published: October 2022

The COVID-19 pandemic created an urgent need for high-quality rapid research. One clinical challenge was how to minimise the risk of transmission in the hospital setting. The CLEAN study conducted a rapid evaluation of the potential utility of a spray-based disinfectant in a hospital setting. The study was undertaken between December 2020 and March 2021 and involved the implementation of the spray in 10 different clinical areas in one UK teaching hospital. A mixed-methods approach was adopted (including observations, surveys, and qualitative interviews) informed by the theories for understanding the implementation of new healthcare technologies. The evaluation found that while the spray had a number of perceived benefits when added to existing disinfection processes, other factors limited its potential utility. These findings informed a number of recommendations for future adoption within hospital settings. This paper describes and reflects on the rapid methodology that allowed us to undertake the study and deliver results in a short space of time. We experienced a number of pressures during set-up and fieldwork due to the challenging conditions caused by the pandemic, and the methodological approach had to evolve throughout the study because of the changing clinical context. The involvement of clinicians from the research setting as full members of the research team was key to the rapid delivery of the research. They provided an essential link to the implementation environment, and their experiential knowledge of the setting added an important perspective to the analysis. Balancing their involvement with their clinical roles was challenging, however, as was coordinating a large and diverse team of interviewers in such a short space of time. Overall, the study highlighted the value of rapid research to inform urgent healthcare decisions in a pandemic. Although our experience suggests that conducting such research requires some practical and methodological trade-offs, we found that there were also numerous benefits of using rapid methods and identified various opportunities to ensure their robustness.
A sense of distance and movement characteristics of golfers tested without visual feedback of outcomes: Is a putt that feels subjectively good also physically good?
Authors: Hasegawa Yumiko , Okada Ayako , Fujii Keisuke
Published: October 2022

For motor tasks that require fine-tuning, such as adjusting the applied force according to the distance to the target, as required for driving and putting in golf, it is important to develop a high degree of sensitivity of one's movement-produced feedback. In previous research focusing on mental representation in golf, this ability to control distance has been called “a sense of distance”. In particular, this study focused on three skills: motor control of the putter head, perception of the impact force, and prediction of the ball's travel distance. However, the relationship between the motor control of the putter head and the error of the outcome estimation is yet to be clarified. The purpose of the present study is two-fold: first, to clarify whether kinematic variation of putter head is correlated with error in estimating the outcome and, second, to quantitatively evaluate the performer's sensations of good and poor performance generated by the ball's impact, for a comparison of the kinematics and impact force of the putter head based on their assessment. Twelve professionals and 12 intermediate amateurs played two distance targets (at 2.4 and 4.8 m) without visual feedback of the outcomes. The kinematics of the putter head, impact force, final ball position, outcome estimation, and subjective assessment were measured. Our results show that the variability in the peak velocity was moderately correlated with the error of the outcome estimation in amateurs' 4.8-m putting task. In addition, amateurs estimated undershoots (overshoots) when they provided worse (better) evaluations. However, the amateurs' trials that were rated as better putts were actually overshoots. These results suggest that the subjectively “good putt” of amateurs was not physically good, and the amateurs putted hard to compensate for the risk of undershoots. However, no remarkable feature of the professional's sense of distance was found. This suggests that professional golfers' sensation is not significantly different from the outcomes that can be physically detected.
Prognostic nutrition index predicts short-term surgical complications in patients with rectal cancer after laparoscopic surgery
Authors: Xu Fengming , Meng Cong , Yang Zhengyang , Li Haoze , Gao Jiale , Sun Liting , Zhang Xiao , Wei Qi , Wu Guocong , Yao Hongwei , Zhang Zhongtao
Published: October 2022

Purpose

Surgical complications following laparoscopic rectal cancer surgery remain a major clinical problem. The prognostic nutritional index (PNI) is reportedly associated with postoperative outcomes. We aimed to evaluate the correlation between PNI and short-term surgical complications in patients with rectal cancer after laparoscopic surgery.

Methods

The prospective clinical data of 225 patients with rectal cancer receiving laparoscopic surgery between January 2021 and April 2022 were retrospectively analyzed. The cut-off values and diagnostic accuracy of PNI preoperatively and on postoperative day (POD) 1 were determined using receiver operating characteristic (ROC) curves. Univariate and multivariate analyses were performed to identify clinical characteristics and risk factors for surgical complications.

Results

In total, 81 (36.0%) patients developed surgical complications. The optimal cut-off value for preoperative PNI was 40.15, and that for PNI on POD 1 was 35.28. The DeLong test found no statistically between–group difference in the area under the ROC curve (P = 0.598). Multivariate analysis identified that a preoperative PNI ≤40.15 [odds ratio (OR): 2.856, 95% confidence interval (CI): 1.287–6.341, P = 0.010] and PNI on POD 1 ≤35.28 (OR: 2.773, 95% CI: 1.533–5.016, P = 0.001) were independent risk factors for surgical complications. Patients with a preoperative PNI ≤40.15 or PNI on POD 1 ≤35.28 were more likely to have surgical complications after laparoscopic surgery for rectal cancer (61.1% vs. 31.2%, P = 0.001; 53.0% vs. 28.9%, P = 0.001).

Conclusion

Preoperative and POD 1 PNI were independent predictors of short-term surgical complications after laparoscopic surgery for rectal cancer.
Primary closure combined with C-tube drainage through cystic duct after laparoscopic common bile duct exploration is safe and feasible for patients
Authors: Sui Xin , Sui Zhenghui , Gu Xingwei , Ding Mingjin , Miao Ganggang
Published: October 2022

Objective

Biliary duct management is of great significance after laparoscopic cholecystectomy (LC) combined with laparoscopic common bile duct exploration (LCBDE) in the treatment of cholecystolithiasis accompanied with common bile duct (CBD) stones. This study is to evaluate the safety and effectiveness of primary closure with C-tube drainage through cystic duct after LC + LCBDE.

Methods

Through a retrospective study, 290 patients who underwent LC + LCBDE in our hospital from January 2019 to April 2022 were enrolled and divided into 2 groups. 143 patients underwent primary closure with C-tube drainage through cystic duct (C-tube group) and the other 147 patients underwent traditional T-tube drainage (T-tube group). Personal information, perioperative examinations, surgical results, and follow-up results were collected and analyzed.

Results

There were no significant differences in the average age, gender, the mean of CBD diameters and the rate of comorbidities (acute cholecystitis, obstructive jaundice, acute pancreatitis and acute cholangitis) between the two groups (P > 0.05). Hospital stay, postoperative hospital stay were significantly shorter in the C-tube group than T-tube group (P < 0.05). In addition, the average time of placing and removal the drainage tubes was significantly less than those of the T-tube group (P < 0.05). This study also showed significant differences in the incidence of postoperative abdominal infection and soft tissue infection in the two groups (P < 0.05). There were no significant differences in the incidence of postoperative complications including cholangitis, bile duct stenosis, mortality in two groups. There were also no significant differences between the two groups of the recurrence of CBD stones, reoperation and readmition in 30 days during the median follow-up of 6 months.

Conclusions

Compared with T tube drainage, patients with C-tube drainage after LC + LCBDE with primary closure of cystic duct recovered faster and had fewer complications. C-tube drainage is a safe and feasible treatment option for patients with cholecystolithiasis and choledocholithiasis.
Increasing Structural Performance of Space Telescope Mirrors through Simultaneous Shape and Size Optimization
Authors: Warzecha Marcel , Schatz Markus E. , Lucarelli Stefano , Jüttner Cedric
Published: October 2022

In this paper, a numeric optimization approach for designing space telescope mirrors will be presented. It is fundamental to space telescopes that each element—including their mirrors—are as lightweight as possible. Moreover, the performance of space telescopes is driven by how strongly these mirrors are distorted upon removal of gravitational load. These distortions result in a deterioration in the optical performance, which is also known as the wavefront error. This error can best be described via Zernike polynomials. To increase the optical performance, along with making the mirror lightweight, the overall root mean square (RMS) of the deformation is used as the optimization objective. An approach utilizing size and shape variables is used to define the feasible design space for the optimization. Lastly, general findings will be discussed, as well as numerical advantages of deploying structural optimization (e.g., robustness evaluation).
Role of Digital Empowerment in Developing Farmers’ Green Production by Agro-Tourism Integration in Xichong, Sichuan
Authors: Zhong Yi-Ping , Tang Lin-Ren , Li Ying
Published: October 2022

Minimal participation in green agricultural development may be achieved via the conventional integration of agriculture and tourism, which has a minimal impact on farmers’ green output. New traits have emerged as a result of agro-tourism integration with digital empowerment. It was shown that agro-tourism integration with digital empowerment had a stronger impact on farmers’ green output than traditional agro-tourism integration, based on the construction of the dynamic information game model and the case of Xichong, Sichuan. The integration of agriculture and tourism from the perspective of digital empowerment is characterized by “data traceability” and “information diffusion”, which restrains opportunistic farmer impersonation. The feature of “knowledge sharing” promotes the progress of agricultural technology, reduces the cost of green production and increases the probability of farmers producing high-quality agricultural products. The “information matching” feature promotes the symmetry of quality information, and production and sales information at both ends of supply and demand, and raises the prices of high-quality agricultural products. The latter two features jointly enhance the willingness of honest farmers to produce green items by reducing the cost of green production and increasing the prices of high-quality agricultural products. From the perspective of digital empowerment, the integration of agriculture and tourism can further promote farmers’ green production by effectively suppressing opportunistic farmers’ fake behavior and promoting honest farmers’ green production to a greater extent.
Sorghum–Grass Intercropping Systems under Varying Planting Densities in a Semi-Arid Region: Focusing on Soil Carbon and Grain Yield in the Conservation Systems
Authors: Ferraz-Almeida Risely , Albuquerque Carlos Juliano Brant , Camargo Reginaldo , Lemes Ernane Miranda , Soares de Faria Renato , Quintão Lana Regina Maria
Published: October 2022

A major challenge in sorghum intercropping systems is maintaining their yields compared to the yields of the solo crops, especially in arid and semi-arid regions. This study aimed to test the hypothesis that intercropping systems using sorghum (Sorghum bicolor (L.) Moench.) and Brachiaria sp. are viable means to increase sorghum production and soil carbon in the conservation systems. Field trials were conducted in the semi-arid region of Minas Gerais, Brazil, during two crop cycles of sorghum associated with different grasses (Andropogon gayanus—AG; Cenchrus ciliaris cv. Aridus—CCA; Cenchrus ciliaris cv. 131—CC; Brachiaria decumbents—BD; Brachiaria brizantha—BB; Brachiaria ruziziensis—BR; Panicum maximum—PM), using row spacings of 0.4 and 0.8 m. Panicles of sorghum (yield) and grass dry matter were collected to determine yields. Results showed that the addition of grasses in systems decreased the grain yield in all systems, except in the systems using sorghum with CCA in 0.4 m, AG in 0.8 m, or BR in 0.8 m. In the 0.4 m row spacing, the sorghum associations with CC, BB, or PM are greater alternatives to increase soil carbon. However, when the row spacing was increased, the sole sorghum was the best alternative to increase the carbon. In machine learning, sorghum systems with CCA and AG are better alternatives to increase the yields, while sorghum with CC, PM, BR, and BB increases the grass dry matter in soil.
Double-Arm Cooperation and Implementing for Harvesting Kiwifruit
Authors: He Zhi , Ma Li , Wang Yinchu , Wei Yongzhe , Ding Xinting , Li Kai , Cui Yongjie
Published: October 2022

Double-arm picking robots are widely used in agricultural production for their high collaborative efficiency. While picking, area planning and collision detection between the mechanical arms is a crucial challenge for the double-arm robot, which needs to establish a collision-free path for fruit picking. In this study, we developed a double-arm cooperation method for robotic picking of kiwifruit. Firstly, the problem of dividing the picking area was simplified into a multiple traveling salesmen problem (MTSP) to be solved. The picking sequence of each robotic arm was formulated by the principle of similar picking numbers, and combined with the brainstorming optimization algorithm (BSO). Secondly, a double-arm parameter model was built to solve the forward and backward movements of the robotic arms and to figure out the joint position. The spatial mathematical relationship of the bounding boxes between the robotic arms was used to detect the collision between the two robotic arms, in order to achieve the avoidance between the robotic joints. Then, simulation software was applied to the simulation and analyzed the availability of picking area planning and collision detection. The simulation results showed that the optimized picking sequence planning using BSO was more efficient; the smooth joint trajectory during the movement of the robotic arms met the limits on the range of movement and on the angular velocity of the robotic arm joints. Finally, based on the simulation result, a double-arm collaboration platform was tested. The double-arm collaboration platform harvesting trials showed that the average picking success rate was 86.67%, and collision detection time was 3.95 ± 0.83 s per fruit. These results indicated that the proposed method could plan the operation tasks of the double-arm picking robot system, and effectively implement the collision-free picking operation.