bluuebunny/crossref_metadata_2025 huggingface dataset:
COMPARISON OF GLYCATED HEMOGLOBIN AND GLYCATED ALBUMIN IN TYPE 2 DM PATIENTS WITH AND WITHOUT CAD
Authors: Siregar Andini Triasti , Akbar Nizam Zikri , Nasution Burhanuddin
Published: December 2018

Diabetes has been associated with Coronary Artery Disease (CAD). The atherosclerosis, underlying the pathogenesis of CAD, has been activated since the early stages of hyperglycemia and accelerated with uncontrolled blood sugar level fluctuations. Therefore, sensitive glycemic markers are required to be used as a screening instrument such as a traditional glycated hemoglobin A1c (HbA1c) glycated hemoglobin marker and non-traditional Glycated Albumin (GA). This study was a cross-sectional conducted on May - July 2017 at the Adam Malik Hospital Medan. Subjects were patients with HbA1c> 7%, Hb> 10 g/dL and albumin> 3 g/dL, divided into DM+CAD and non-CAD DM groups. Sixty patients participated in this study consisting of 36 males (60%) and 24 females (40%), with a mean age of 56 years. There was a significant difference between HbA1c and GA between the non-CAD DM group and DM + CAD (p=0.001; 0.022.) Patient characteristics did not affect CAD complications in DM patients; a significant difference indicated that poor glycemic control increased the complication of CAD in patients with DM type 2. Glycated albumin examination is recommended for patients with type 2 diabetes with CAD.
THE DIFFERENCES VALUE OF P-LCR, THE Î’-THROMBOGLOBULIN LEVEL, THE FIBRIN DEGRADATION PRODUCTS LEVEL IN PRE AND POST-HEMODIALYSIS
Authors: N Like R , P Purwanto A , W Dian
Published: December 2018

Hemostasis disorders in End Stage Renal Disease (ESRD) might be due to uremia syndrome which causing platelet dysfunction. This condition was worsened by chronic hemodialysis which affected the biologic compound degranulation of thrombogenic Î²-thromboglobulin causing morphological changes of platelets which could be evaluated by using the value of Platelet Large Cell Ratio (P-LCR) and triggering fibrinolysis hyperactivation which increased the Fibrin Degradation Products (FDP) level. The sequence of this mechanism happened continuously. The platelet index evaluation could decide the prognosis after hemodialysis, in addition to monitoring creatinine levels. This study aimed to prove the difference between P-LCR, Î²-thromboglobulin level, FDP level and creatinine level between pre and post-hemodialysis. The design of this study was observational analytical. Forty-five samples were examined by complete blood count examination using flowcytometry method, the level of Î²-TG examination by ELISA method, the level of FDP examination by the immunoturbidimetric method and the level of creatinine examination by enzymatic method. The statistical analysis used the Wilcoxon test. It was found that  the value of P-LCR in ESRD pre-hemodialysis was higher than in post-hemodialysis with the median 26.8 fl and 25.4 fl, the Î²- thromboglobulin level increased inpost-hemodialysis compared to pre-hemodialysis (median 200.88 pg/mL and 313.48pg/mL), the FDP level was higher in  post-hemodialysis compared to pre-hemodialysis, (median 1.15 µg/mL and 1.7µg/mL), the creatinine level was lower in   post-hemodialysis compared to pre-hemodialysis, (median 13.04 mg/dL and 4.56 mg/dL). Therefore, the statistical value was p<0.01. There were significant differences in P-LCR-value, Î²-thromboglobulin level, fibrin degradation products level and creatinine level between pre and post-hemodialysis.
DIFFERENCES OF LIVER FUNCTION TESTS IN TYPE 2 DIABETES MELLITUS PATIENTS WITH AND WITHOUT CORONARY ARTERY DISEASE
Authors: Saputra Hendra , Nasution Burhanuddin , Syafril Santi
Published: December 2018

One of the macroangiopathic complications of Diabetes Mellitus (DM) is Coronary Arterial Disease (CAD). Several studies showed that the liver was one of the organs involved in the pathological development of diabetes.The aim of this study was to find the differences of liver function in type 2 DM patients with CAD and without CAD. This was an analytical observational study with cross-sectional design. Forty-four type 2 DM patients with and without CAD at the Adam Malik Hospital Medan who came during June - August 2016 were studied for liver function (total bilirubin, direct bilirubin, AST and ALT). In this study, the average values of total bilirubin and direct bilirubin level in patients with CAD were found to be lower than without CAD. Statistically a significant difference revealed a total bilirubin (p < 0.001) and direct bilirubin (p = 0.001) in type 2 DM patients with and without CAD. There was a significant difference in liver function tests in DM type 2 patients with, and without coronary arterial disease, these data suggested that total billirubin and direct billirubin levels in type 2 DM patients with CAD were found lower than those without CAD.
COMPARISON OF HBA1C LEVEL USING TURBIDIMETRY INHIBITION IMMUNOASSAY, LATEX AGGLUTINATION INHIBITION METHOD AND HPLC METHOD
Authors: Sutandra Salmon , Nurulita Asvin , Arif Mansyur
Published: December 2018

According to the National Glycohemoglobin Standardization Program (NGSP) and The Diabetes Control and Complication Trial(DCCT) the standard method of measuring HbA1c is High-Performance Liquid Chromatography (HPLC), but HPLC requiresparticular instrument investments, trained staff, long and relatively expensive sample processing. This an instrument that hassimilar performance to HPLC but its operation process is relatively simple and not costly. The purpose of this study was to analysethe HbA1c level using Turbidimetry Inhibition Immunoassay (TII) method and the HPLC method; to analyse HbA1 level using LatexAgglutination Inhibition (LAI) method and HPLC method. This research was conducted with a cross-sectional design during theperiod of March-April 2017. The total sample consisted of 160 samples divided into two groups. For the first group, HbA1c levelusing TII method and HPLC method was measured. For the second group, HbA1c level was measured using LAI method and HPLCmethod.The data obtained were analyzed using the Paired T-test. There was a significant difference between HbA1c levels usingTII method and HPLC method {8.12(2.53)% vs. 8.49(2.63)%, p<0.001}. There was no significant differences between HbA1c levelsusing LAI method and HPLC method {7.52(1.95%) vs. 7.47(2.00)%, p>0.05}. This research concluded that there was a differencebetween the HbA1c levels using TII method and HPLC method, but no difference between HbA1c levels using LAI method and HPLC method.
Quem ensina braille para alunos cegos? – A formação de professores em questão
Authors: Batista Rosana Davanzo , Amaral Mateus Henrique do , Monteiro Maria Inês Bacellar
Published: December 2018

Esse texto objetiva analisar as implicações das prescrições oficiais e currículos de formação de professores na (não) aprendizagem de braille por alunos cegos nas escolas regulares. Para isso, discute a legislação vigente e práticas relativas à formação inicial, especializações e cursos de curta duração. Conclui que a escassez de cursos formativos de professores de Educação Especial e a ausência de conteúdos sobre a educação de alunos com deficiência nos cursos de licenciatura indicam a falta de espaços que garantam o conhecimento do que é geral e particular para o ensino dos alunos cegos na educação escolar.
Meios auxiliares e caminhos alternativos: o aluno com autismo e a prática pedagógica
Authors: Santos Emilene Coco dos , Oliveira Ivone Martins de
Published: December 2018

Este trabalho analisou as possibilidades do uso de meios auxiliares e caminhos alternativos na intervenção pedagógica realizada em uma turma do primeiro ano do ensino fundamental que tinha, entre seus alunos, um menino com autismo. Utilizou, como suporte teórico, a perspectiva histórico-cultural. Constatou que as ações diferenciadas da prática pedagógica se orientaram em duas direções: aspectos organizativos da escola, que procuravam garantir os apoios necessários ao professor regente e ao aluno; ações voltadas especificamente para os processos de ensino e de aprendizagem. Concluiu que investir em ações diversificadas, em colaboração intensiva com a criança e significativas para ela, é um caminho importante para tracionar seu desenvolvimento cultural.
A COLONIZAÇÃO ALEMÃ EM MARECHAL CÂNDIDO RONDON E O ENXAIMEL
Authors: Hirt Sidnara , Soares Karen Alessandra Solek
Published: December 2018

O presente trabalho tem o objetivo de estudar a presença da linguagem arquitetônica do estilo enxaimel em cidades brasileiras com colonização alemã, através de um estudo de caso sobre a cidade de Marechal Cândido Rondon. Considerando o fato de esta cidade sofrer influência da cultura germânica, através das características presentes na arquitetura do município, foi realizado um levantamento de obras com a particularidade da técnica construtiva enxaimel, e identificada a sua reprodução em obras que possuem apenas ornamentos, mas mantendo a linguagem.
A ARQUITETURA NA REPRODUÇÃO DA MEMÓRIA: O CAMINHO DE PEABIRU
Authors: Franciscon Anderson , Marques Caroline Salgueiro da Purificação , Azuma Mauricio Hidemi
Published: December 2018

O Caminho de Peabiru foi uma rede de caminhos de precedência indígena, seccionando o continente sul-americano de leste a oeste. Na região de Campo Mourão-PR muitos têm sido os estudos referentes ao Caminho, no entanto, não há estudos sobre a necessidade de memorá-lo por meio da arquitetura. A ausência de um espaço destinado à salvaguarda do Peabiru faz com que o início da habitação e deslocamento humano pela região seja esquecido e desconhecido por muitos. Uma solução para o resgate arqueológico do Peabiru seria a construção de um Memorial, pois vários foram edificados com a finalidade de perpetuar uma história específica. Esta pesquisa de revisão literária tem por objetivo identificar a função da arquitetura em resgatar acontecimentos históricos, revelando à necessidade de memorar o Caminho de Peabiru e quais pontos e programas de necessidade a obra deve explorar. Conclui-se que o (Memorial Caminho de Peabiru) deverá conter signos de forma a fazer com que o usuário relembre e reviva o Caminho, bem como apresentar uma proposta de edifício que possa abrigar atividades para o desenvolvimento de estudos, apresentações artísticas e culturais, exposições literárias, de artefatos indígenas e de pioneiros da região.
ANÁLISE DO LIVRO “OS 13 PORQUÊS”: UMA DISCUSSÃO SOBRE O SUICÍDIO SOB A ÓTICA ANALÍTICO COMPORTAMENTAL
Authors: Vendruscolo Defante Karla Jordana , Silva Natiele Taisy da , Aoyama Patrícia Cristina Novaki
Published: December 2018

Este trabalho tem como objetivo compreender o comportamento de suicídio por meio da ótica da Análise do Comportamento. Para tanto, foi utilizada a literatura do livro “Os 13 porquês”, que conta a história de uma adolescente que se suicida. Segundo a Análise do Comportamento, as variáveis ambientais afetam a maneira como o indivíduo se comporta no mundo, o contexto ao qual faz parte tem uma importante influência na constituição da história de vida do sujeito. Na obra analisada, a protagonista passa por várias situações aversivas que acabam levando-a ao contexto do suicídio, tais como bullying e violência sexual, que culminaram em vivências de sofrimento muito intensas. Observou-se também que a adolescente não apresentava repertório de enfrentamento, de pedidos de ajuda mais explícitos, além de não possuir uma rede de apoio efetiva que a auxiliasse em suas dificuldades, o que também agravou seu quadro de sofrimento culminando no suicídio.
Meshless method simulation and experimental investigation of crack propagation of CBM hydraulic fracturing
Authors: Wen Guojun , Liu Haojie , Huang Hongbo , Wang Yudan , Shi Xinyu
Published: December 2018

For simulating CoalBed Methane (CBM) hydraulic fracturing using 3-D meshless method, this paper analyzed the hydraulic fracturing mechanism and cracking form for coal rock and established the geometric and mathematical models of hydraulic fracturing propagation in coal rock in terms of the Hillerborg model on crack opening displacement theory. With the theoretical basis of hydromechanics, the formulas for calculating hydraulic pressure inside the fracture by numerical simulation were deduced from the analysis on this fluid-structure interaction problem. The geometric and mathematical models established above were described by 3-D meshless Galerkin (EFG, Element-Free Galerkin) method and compiled into the numerical simulation program using VB and FORTRAN programming language to simulate the fracture propagation for an actual coal rock sample with a drilling hole as an example. Then the physical simulation experiment of hydraulic fracturing propagation of coal seam was conducted on the same coal rock sample. Through the direct observation with naked eyes and detection by advanced instruments of ESEM and Micro-CT, the shape and parameters of cracks on the surface of and inside the coal rock sample were achieved, which indicated that experimental results are reasonably consistent with numerical simulation results.
BEŞ FAKTÖR KİŞİLİK ÖZELLİKLERİNİN KARİYER DEĞERLERİ ÜZERİNDEKİ ETKİSİ: ÜNİVERSİTE ÖĞRENCİLERİ ÜZERİNE BİR ARAŞTIRMA
Authors: İÇERLİ Leyla , UĞUZ ARSU Şerife
Published: December 2018

Bu çalışmanın amacı,
öğrencilerin kariyer tercihlerini belirlemede etkili olan kariyer değerleri
üzerinde kişilik özelliklerinin etkisini incelemektir. Bu amaçla, Aksaray
Üniversitesi İktisadi ve İdari Bilimler Fakültesi’nde öğrenim gören 802 öğrenci
üzerinde bir araştırma yapılmıştır. Araştırmada beş faktör kişilik boyutları
ile kariyer değerleri boyutları arasında istatistiksel açıdan pozitif yönlü
anlamlı ilişkiler bulunmuştur. Araştırma bulgularına göre kişiliğin;
sorumluluk, duygusal denge ve gelişime açıklık boyutlarının, kariyer değeri
olan otonomi üzerinde, dışadönüklük, duygusal denge ve uyumluluk boyutlarının
güvenlik boyutu üzerinde, gelişime açıklık ve uyumluluk boyutlarının teknik
yetkinlik üzerinde, sorumluluk ve gelişime açıklık boyutlarının yönetimsel
yetkinlik üzerinde, gelişime açıklık ve sorumluluk boyutlarının girişimcilik
boyutu üzerinde, sorumluluk, dışadönüklük ve gelişime açıklık boyutlarının
amaca kendini adama boyutu üzerinde, gelişime açıklık ve sorumluluk
boyutlarının meydan okuma boyutu üzerinde, uyumluluk, duygusal denge ve
sorumluluk boyutlarının hayat tarzı boyutu üzerinde anlamlı etkilerinin olduğu
tespit edilmiştir.
Análisis comparativo de los moluscos en la reserva de la biosfera Los Petenes y lagunas costeras del sureste de México
Authors: González-Solis Alicia , Torruco Daniel , Torruco-González Ángel D.
Published: December 2018

The phylum Mollusca is widely distributed in all types of environments. The species it contains are important for their multiple uses as food (as part of several trophic chains), as vectors of other groups of organisms, for the extraction of substances, and as sentinels ofnatural and induced environmental changes. In this work, a comparative evaluation of the malacological biodiversity associated with different habitats in the Los Petenes Biosphere Reserve in Campeche and in eight coastal water bodies in southeastern Mexico was performed.To obtain data comparable to those that were used in a previous study, data from the Los Petenes mollusks were obtained by collection of sediment cores 10 cm in diameter at a depth of 15 cm at 20 sites in different habitats every four months during 2014. For the other lagoons,records were obtained from various published sources. For Los Petenes, a total of 175 species and 12,850 individuals were recorded. The species Rissoella caribaea was the most common and the most abundant. Comparative evaluation of each of the habitats that coexist in this ecosystem did not show significant changes in abundance. Similarly, faunal associations exhibited a sea-land gradient, and although thedifferences in biomass were significant, species richness did not show the same pattern among habitats. The Los Petenes system as a whole exhibited some of the greatest biodiversity among the water bodies analyzed, and the Terminos lagoon showed the highest biodiversity (169and 175 species, respectively). In contrast, the Sabancuy estuary featured fauna records with a richness of 43 species; in the Tupilco-Ostión lagoon, only 62 species were recorded, and in the rest of the lagoons, the numbers of species were even lower.
Fauna asociada a la pesquería de Arca Zebra (Mollusca Bivalvia: Arcidae) en Venezuela
Authors: Díaz-Fermín Roberto , Acosta-Balbás Vanessa
Published: December 2018

Arca zebra, constitutes one of the fishing resources with the greatest economic impact in northeastern Venezuela, since it forms banks of commercial importance. During a period of nine months (May 2010-August2011) the community structure of the organisms from the trawling fishery carried out by the fishermen of the area was identified, quantified and described. The biomass and abundance of the different groups were estimated to perform Abundance-Biomass Comparison Curves (ABC) with the objective of determining the degree of affectation by the trawling activity. A total of3 249 organisms belonging to 130 species were grouped in five Phyla: Mollusca, Annelida, Arthropoda, Echinodermata and Chordata. The Sanders' diversity index was 122.9 with mollusks (70.87) and polychaetes (29.91) as the most diverse taxa. Mollusks had the highest abundance followed by polychaetes, crustaceans, echinoderms and ascidians. Mollusks and echinoderms made the largest contribution to total biomass. The most frequent species were: Mithraculus forceps, Phallucia nigra, Echinometra lucunter, Eunice rubra and Pinctada imbricata. The microgastropods Triphora melanura is recognized as a new record for the area and the polychaete Oenone fulgida, for Venezuela. The ABC curve showed that total abundance of organisms was above total biomass, suggesting that the fishery of Arca zebra has a negative effect on most groups of organisms, mainly on echinoderms, since many of them suffer strong physical damage at the time of extraction, therefore, there is a need to modify the trawl nets, increasing the mesh opening, butwithout endangering the economic viability of the fishery.
Primer registro de la interacción entre Isistius sp. (Elasmobranchii: Dalatiidae) y Balaenoptera physalus (Mysticeti: Balaenopteridae) en aguas venezolanas
Authors: Esteves Juan , Figueredo Arnaldo , Acosta Rodrigo , Lira Carlos , Bermúdez-Villapol Luis
Published: December 2018

The stranding of an adult male Balaenoptera physalus (Mysticeti: Balaenopteridae) in Los Cocoteros Beach in Margarita Island, Venezuela, gave the chance of studying the interactions present in it. 33 injuries were found in several points of rorqual tegument; oval or rounded in shape, like craters, from 5 to 7 cm long, 5 to 6 cm wide, and 3 to 5 cm deep. Most of them, were fresh. Wounds were attributed to the cookie cutter shark Isistius sp. (Elasmobranchii: Dalatiidae), given the remarkable correspondences. The present noteconstitutes the first known association between the cookie cutter shark and the fin whale in Venezuelan, Caribbean and western Atlantic waters.
Amplificación cruzada de microsatélites en dos especies de haemúlidos (Haemulon aurolineatum y Haemulon steindachneri)
Authors: Pabón Quintero Paula E. , Tavera José Julian , Millán-Márquez Ana María , Acero P. Arturo
Published: December 2018

Genetic-population studies in marine fish have allowed to study patterns of dispersal and connectivity between habitats. Oneimportant tool in population genetics is the use of microsatellite molecular markers. Cross-amplification of microsatellite is amethod that consists in using primers designed for one species in a different one but phylogenetically related. Because of theimportance of genetic studies of populations in artisanal fisheries species, primers were evaluated and designed for the species Haemulon aurolineatum and Haemulon steindachneri. Samples were collected from the artisanal fisheries in Barú-Colombia. Amplification was standardized for 12 microsatellites which ten were polymorphic for H. aurolineatum and nine for H. steindachneri. It is considered that the primers implemented in this study are useful for future studies of gene flow in these species.
Estudios preliminares de las características espermáticas y de criopreservación del coral formador de arrecifes Orbicella faveolata
Authors: Vanegas María Juliana , Pizarro Valeria
Published: December 2018

Cryopreservation has been recently applied to coral gametes and tissue with successful results that can be applied for different purposes on coral conservation and restoration. In this study, we decided to determine the sperm morphology of the coral Orbicella faveolata and assess the feasibility of sperm cryopreservation using a combination of intracellular (1,2-Propadiol) and extracellular (milk) cryoprotectants, and two frozen treatments for 24 h. Mature spermatozoa had a triangular-like head shape measuring 4.10 ± 0.69 μm(mean ± SD) and long flagellum (43.24 ± 7.99 μm). Fresh sperm remained viable and mobile for more than five hours after being released from the gamete bundles. After cryopreservation, all post-thaw sperm components assessed (morphology, motility and viability) showed no difference in contrast to fresh sperm. This study is the first report of cryopreservation of O. faveolata sperm, however further research is needed to increase the success of the cryopreservation protocol for broad-scale application.
Estructura de la comunidad bacteriana en diferentes tejidos de Lobatus gigas silvestres (Linnaeus, 1758) de la Reserva de Biosfera Seaflower del Caribe
Authors: Higuita-Valencia Mónica Marcela , Montoya Campuzano Olga Inés , Márquez Fernández Edna Judith , Moreno Herrera Claudia Ximena
Published: December 2018

The microbial diversity of Lobatus gigas has not been thoroughly studied despite of them is a specie endangered. Knowledge of microbiota may help to improve the conservation and cultivation of this species. The objective of this study was to evaluate the bacterial populationsassociated with the gonad and the gut compartments of the wild endangered L. gigas from the Caribbean Seaflower Biosphere Reserve, using microbiological methods and culture-independent molecular tools. The genetic profiles of the bacterial populations were generated and Temporal Temperature Gradient Electrophoresis (TTGE) was used to compare them with total DNA. A genetic and statistical analysis of the bacterial communities revealed a low level of diversity in gonad tissue based on the number of bands detected using TTGE. In addition, statistical differences in bacterial community structure were found between the foregut and hindgut tissue of L. gigas. The dominant phylogenetic affiliations of the gonad bacteria, as determined using 16S rRNA gene sequencing, belong to Ralstonia (50%). The possible involvement of this genus in the reproduction and development of the conch is discussed. On the other hand, the bacterial phylotypes from foregut and hindgut included members of  Alphaproteobactera (12.5%), Betaproteobacteria (12.5%), Gammaproteobacteria (12.5%), Bacilli (31.25%), Clostridia (6.25%), Actinobacteria (6.25%), Mollicutes (6.25%) and Deinococci (6.25%) classes. Knowing the composition of the gonad and foregut and hindgut bacteria of L. gigas is the first step toward exploring the proper management of this species, as well as provides useful information to future researches that allow a better understanding of the role of these bacterial populations in the health and reproductive rate of L. gigas.
Evidencia de reclutamiento coralino producto de reproducción sexual, en Isla Gorgona, Pacífico Tropical Oriental
Authors: Muñoz Carlos G. , Jaramillo-González Juliana , Zapata Fernando A.
Published: December 2018

We present evidence of coral sexual recruitment, which has typically been low in the Eastern Tropical Pacific, on coral reefs and rocky sites of Gorgona Island, Colombia, and for the first time in the Colombian Pacific. With data obtained by thoroughly examining natural substrates, coral juveniles of at least ten species were found at ten out of 19 sites surveyed during scuba diving explorations performed around the island between 2010-2017; however, no corals were found on settlement plates of five different materials. The two most abundant coral species found as juveniles were Porites panamensis and Pocillopora sp., occurring at mean densities of 5.7 ± 4.7 and 0.07 ± 0.11 colonies m-2 (± SD), respectively, and with mean colony-sizes of 2.3 ± 0.9 cm and 3.5 ± 1.0 cm (± SD), respectively. These results indicate that, even though settlement plates do not seem to be as useful to study coral recruitment in the region as they are elsewhere, coral recruitment derived from the sexual reproduction of a diverse set of species is an active process at Gorgona Island.
Primer registro del copépodo Cymbasoma chelemense (Copepoda: Monstrilloida) en el mar Caribe colombiano
Authors: Dorado-Roncancio Edgar Fernando , Dorado-Roncancio John Henry
Published: December 2018

As part of monitoring in the estuarine inner Bay of Cartagena, Colombia during the year 2016, a female adult specimen ofCymbasoma chelemense was collected and identified. Originally described for the Gulf of Mexico and sharing the followingmorphological and morphometric characteristics: Cephalothorax of at least 68% of the total length of the body. Oral papilla located at least 20% of the total length of the cephalothorax; Ocelli present; genital complex with ovigerous spines located at the base and with one single post genital somites, the ovigerous spines at least 14% longer than the total length of the body and about 10 times the length of urosome. This is the first record of a copepod of the genus Cymbasoma in Colombia estuarine waters, increasing the range of distribution of this species in the Caribbean Sea.
Hypertension approach in patients with chronic kidney disease
Authors: Baltă Mihaela Daniela
Published: December 2018

Most patients with chronic kidney disease (CKD) have hypertension, and CKD is characterized by high and very high cardiovascular disease rates. Hypertension is an important cardiovascular risk factor, and its treatment prevents major cardiovascular events and lowers mortality of all causes and especially cardiovascular mortality. Therefore antihypertensive therapy is part of the management of chronic kidney disease. Effective blood pressure control decreases not only the risk of fatal and non-fatal cardiovascular events, but also reduces the rate of progression of renal impairment. Target bloodline values are not definitively established, but most guidelines recommend lowering systolic blood pressure to values below 140-130 mmHg, depending on the presence of proteinuria. Additional studies are needed to establish the blood pressure (BP) target, especially for patients with GFR below 45 ml/min./1.73 m2, where the benefits of too aggressive BP may be outweighed by the risk of progression to renal insufficiency. Most patients with chronic kidney disease require therapy with two or three therapeutic agents, the most commonly used drugs being ACE inhibitors/ARB (if there is intolerance to ACE inhibitors), calcium channel blockers and diuretics.
Assessment of Constant-Potential Implicit Solvation Calculations of Electrochemical Energy Barriers for H2 evolution on Pt
Authors: Van den Bossche Maxime , Skúlason Egill , Rose-Petruck Christoph , Jonsson Hannes
Published: December 2018

Theoretical estimation of the activation energy of electrochemical reactions is of critical importance but remains challenging. In this work, we address the usage of an implicit solvation model for describing hydrogen evolution reaction steps on Pt(111) and Pt(110), and compare with the `extrapolation' approach as well as single-crystal measurements. We find that both methods yield qualitatively similar results, which are in fair agreement with the experimental data. Care should be taken, however, in addressing spurious electrostatic interactions between periodically repeated slabs in the VASPsol implementation. Considering the lower computational cost and higher flexibility of the implicit solvation approach, we expect this method to become a valuable tool in electrocatalysis.
Highly Adjustable 3D Nano-Architectures and Chemistries via Assembled 1D Biological Templates
Authors: Ohmura Jacqueline F. , Burpo F. John , Lescott Chamille , Ransil Alan , Yoon Youngmin , Records William , Belcher Angela
Published: December 2018

Porous metal nanofoams have made significant contributions to a diverse set of technologies from separation and filtration to aerospace. Nonetheless, finer control over nano and microscale features must be gained to reach the full potential of these materials in energy storage, catalytic, and sensing applications. As biologics naturally occur and assemble into nano and micro architectures, templating on assembled biological materials enables nanoscale architectural control without the limited chemical scope or specialized equipment inherent to alternative synthetic techniques. Here, we rationally assemble 1D biological templates into scalable, 3D structures to fabricate metal nanofoams with a variety of genetically programmable architectures and material chemistries. We demonstrate that nanofoam architecture can be modulated by manipulating viral assembly, specifically by editing the viral surface coat protein, as well as altering templating density. These architectures were retained over a broad range of compositions including monometallic and bi-metallic combinations of noble and transition metals of copper, nickel, cobalt, and gold. Phosphorous and boron incorporation was also explored. In addition to increasing the surface area over a factor of 50, as compared to the nanofoam’s geometric footprint, this process also resulted in a decreased average crystal size and altered phase composition as compared to non-templated controls. Finally, templated hydrogels were deposited on the centimeter scale into an array of substrates as well as free standing foams, demonstrating the scalability and flexibility of this synthetic method towards device integration. As such, we anticipate that this method will provide a platform to better study the synergistic and de-coupled effects between nano-structure and composition for a variety of applications including energy storage, catalysis, and sensing.
An Exploration Strategy Improves the Diversity of de novo Ligands Using Deep Reinforcement Learning – A Case for the Adenosine A2A Receptor
Authors: Liu Xuhan , Ye Kai , Van Vlijmen Herman , IJzerman Adriaan P. , Van westen Gerard JP
Published: December 2018

Over the last five years deep learning has progressed tremendously in both image recognition and natural language processing. Now it is increasingly applied to other data rich fields. In drug discovery, recurrent neural networks (RNNs) have been shown to be an effective method to generate novel chemical structures in the form of SMILES. However, ligands generated by current methods used to provide relatively little diversity and do not fully cover the whole chemical space occupied by known ligands. Here, we propose a new method (DrugEx) to discover de novo drug-like molecules. DrugEx is an RNN model (generator) trained through a special exploration strategy integrated into reinforcement learning. As a case study we applied our method to design ligands against the adenosine A2A receptor. From ChEMBL data, a machine learning model (predictor) was created to predict whether generated molecules are active or not. Based on this predictor as the reward function, the generator was trained by reinforcement learning without any further data. We then compared the performance of our method with two previously published methods, REINVENT and ORGANIC. We found that candidate molecules our model designed that were predicted to be active, had a larger chemical diversity, and better covered the chemical space of known ligands compared to the state-of-the-art.
Rapid Prediction of Anisotropic Lattice Thermal Conductivity: Application to Layered Materials
Authors: McKinney Robert , Gorai Prashun , Toberer Eric S. , Stevanovic Vladan
Published: December 2018

Thermal conductivity plays a crucial role in many applications; use of single-crystal and textured polycrystalline materials in such applications necessitate understanding the anisotropy in thermal transport. Measurement of anisotropic lattice thermal conductivity is quite challenging. To address this need through computations, we build upon our previously developed isotropic model for kL and incorporate the directional (angular) dependence by using the elastic tensor obtained from ab initio calculations and the Christoffel equations for speed of sound. With the anisotropic speed of sound and intrinsic material properties as input parameters, we can predict the direction-dependent kL. We validate this new model by comparing with experimental data from the literature – predicted kL is within an average factor difference of 1.8 of experimental measurements, spanning 5 orders of magnitude in kL. To demonstrate the utility and computational-tractability of this model, we calculate kL of ~2200 layered materials that are expected to exhibit anisotropic thermal transport. We consider both van der Waals and ionic layered structures with binary and ternary chemistries and analyze the anisotropy in their kL. The large-scale study has revealed many layered structures with interesting anisotropy in kL.
On the Chemistry and Mobility of Hydrogen in the Interstitial Space of Layered Crystals H-BN, MoS2 and Graphite
Authors: Kuc Agnieszka , An Yun , Petkov Petko , Lozada-Hidalgo Marcelo , Heine Thomas
Published: December 2018

Recent experiments have demonstrated transport and separation of hydrogen isotopes in layered materials, such as hexagonal boron nitride and molybdenum disulphide. Here, based on first-principles calculations combined with well-tempered metadynamics simulations, we report the chemical interactions and mobility of protons (H+) and protium (H atoms) in the interstitial space of these layered materials. We show that both H+ and H can be transported between the layers of h-BN and MoS2 with low free energy barriers, while they are immobilized in graphite, in accordance with the experimental observations. In h-BN and MoS2, the transport mechanism involves a hopping process between the adjacent layers, which is assisted by the low- energy phonon shear modes. Defects present in MoS2 suppress the transport and act as traps for H species.
Framing the Right to Be Forgotten: A Transatlantic Cultural Clash? A Comparative Newspaper Analysis
Authors: Telesca Elisa
Published: December 2018

This research tests the presence of a difference of approaches to the Right to Be Forgotten (RTBF), as introduced in Article 17 of the General Data Protection Regulation (GDPR), in the media and public sphere. The focus is put on how European and US newspapers have framed the Right between 2010 and 2018. The objective is to understand how news media have presented and described the RTBF to their readers at the national level in Italy, the UK, and the US, and how such discourses reflect alleged cultural disparities.  The RTBF is hereby conceptualized as a multi-dimensional notion. It is argued that the Right can be seen from perspectives other than those related to free speech and privacy, as advanced by the academic literature. The umbrella concept of transparency is introduced as a new way to frame the RTBF, concerning transparency for and from the people, on an individual level. On the one hand, Article 17 GDPR refers to a right to transparency for the people, to know and access lawful online information about, in particular, public figures or criminals. The notion also entails a form of transparency from the people: individuals should be transparent about their past, in real life and online. On the other hand, the RTBF can also refer to a right to be “not fully transparent” online, or a right to non-transparency from the people. This implies that not all information should be published on the Internet, especially when it represents personal and sensitive data.
On the Ones Who Hear the Whistle: Towards an Analytical Framework for Analysing Complaint Recipients
Authors: Rathke Selina
Published: December 2018

Tax avoidance, fraud, endangerment of public safety – criminal offences that would often remain hidden without whistleblowers. Although whistleblowing is a common research subject (e.g. Brown, 2008; Culiberg & Mihelic, 2017), few studies systematically focus on the recipients of whistleblowers’ reports. This lack of attention is striking in light of the decisive role of complaint recipients in the whistleblowing process (e.g. Lewis, Brown, & Moberly, 2014; Read & Rama, 2003). Often, it depends on the recipient’s response, whether the process comes to a standstill and injustice prevails, or whether corrective action is initiated. Drawing on the scant existing literature, this study develops and applies a comparative framework which allows for a comprehensive analysis of the role of whistleblowing complaint recipients. Findings confirm the framework’s utility to assess recipients, their responses and responsibilities. Hence, this study paves the way for the application of a novel analytical focus within whistleblowing research.
The End of Privacy? Paradoxes and Dilemmas of Internet Use and Online Surveillance
Authors: Gaumet Carolyn
Published: December 2018

With the Internet growing in importance in our daily lives, concerns about privacy and data protection have emerged. While people worry about where they data may end up, they continue making themselves openly transparent by sharing information about themselves and their lives online. This study aims to understand the paradoxes between privacy considerations – mainly, the wish to keep individual data private and secure – and the actions that people undertake in reality. More specifically, it focuses on three paradoxes and dilemmas of privacy: age, perceived usefulness, and rewards. These will be studied by analyzing the results of a survey, in which respondents from the EU, North America and East Asia were asked about their online habits and their opinions on various security issues and privacy measures. The analysis ultimately aims to further the understanding of privacy paradoxes, and what hinders people from protecting their data sufficiently.
Conclusion
Authors: Rathke Selina
Published: December 2018

Transparency is hard to pin down. While it can be a condition as well as a means and social end, it is the people determining who and what is transparent in which way and why. While this volume’s eight contributions reflect different approaches towards analyzing and discussing different directions of transparency, they overall demonstrate that the phenomenon of transparency is and remains an inexhaustible and highly relevant domain for research.
A 3D quantitative method for analyzing bone mineral densities: a case study on skeletal deformities in the gilthead sea bream, Sparus aurata (Linnaeus, 1758)
Authors: Thuong Nguyen Phuc , Dierick Manuel , De Wolf Tania , Adriaens Dominique
Published: December 2018

Skeletal deformities, one of the major threats for aquaculture, have been studied extensively. These include opercular malformations in gilthead sea bream (Sparus aurata), a key fish species for Mediterranean aquaculture. What is causing it and at what morphogenetic level it arises, however, is still unclear. Here we focus on bone formation, at the level of bone mineralization. Several methods have been used to study bone mineralization density (BMD), however, these are frequently limited when targeting a high-resolution, three-dimensional mapping of BMD. We used micro-computed tomography (micro-CT) data to perform such a 3D quantification of BMD levels in gilthead sea bream that showed different levels of opercular bone deformations. This approach has the advantage of not having to rely on calibration phantoms, as long as relative BMD values are needed. The results show an increased BMD in deformed opercles compared to normal ones, especially in a bilaterally-deformed specimen. Furthermore, we show that opercular deformations are not necessarily associated with similar mineralization patterns in other mineralized cranial elements, except for the otoliths. Also, mineralization seems to occur left-right independently, matching earlier observations of such an independency of the opercular phenotype as a whole. This study confirms that a quantitative characterization of BMD patterns in 3D is feasible, even in smaller specimens, and that it has several advantages over other commonly used approaches.
Sans objet d’Aurélien Bory : pour une chorégraphie intermédiale
Authors: Maubert Oriane
Published: December 2018

Le spectacle Sans objet créé en 2009 par Aurélien Bory révèle un geste de manipulation propre à la marionnette autant qu’un geste chorégraphique. Il propose la rencontre chorégraphique de deux danseurs avec un robot industriel détaché de sa fonction d’origine : le robot, sorti de son usine, se retrouve sans objet, dépossédé de son utilité, dans la nudité et l’isolement les plus extrêmes face au monde. Chez Bory, l’illusion de l’animation est, dès le départ, renégociée dans ce jeu de dialogue chorégraphique entre robot et danseur, objet en mouvement et corps vivant, se détournant alors, par le geste chorégraphique, de la question de l’inertie présente en marionnette. De quelle façon cette rencontre intermédiale entre robot et danseurs parvient-elle à créer une confrontation chorégraphique entre ces deux corps, l’un de chair, l’autre de matière, a priori opposés ?
Qu’est-ce que l’art chorégraphique peut montrer du corps migrant ? Une étude des chorégraphies Ethnoscape de Cécile Proust et Rester. Étranger de Barbara Manzetti
Authors: Mesager Mélanie
Published: December 2018

Lorsqu’une chorégraphie comme Ethnoscape de Cécile Proust, qui traite du sujet des migrations humaines, est présentée sur scène au public, elle se trouve prise dans un contexte de réception politique et éthique d’autant plus brûlant qu’il touche à une actualité immédiate et médiatisée. C’est cette rencontre que l’article proposé commence par interroger : comment rendre présents les corps des immigrés, à travers leurs témoignages, leurs voix, leurs images ? Leur présence différée ne marque-t-elle pas inéluctablement leur absence ? Comparant ce projet avec celui de Barbara Manzetti qui fait venir des réfugiés politiques dans le lieu de sa résidence artistique, je m’emploie à montrer que ces choix ne hiérarchisent en aucun cas la valeur des œuvres, mais sont fondamentaux quant à la façon dont chacune des chorégraphies tend à s’inscrire dans le discours contextuel sur la migration. Changeant d’échelle, je peux alors montrer que la démarche chorégraphique de Proust ne se limite pas à s’inscrire dans la polémique d’une époque, mais qu’elle est l’histoire de toute une vie où danse et migration sont intimement liées, et où il s’agit de chorégraphier le mouvement du voyage et de la rencontre.
Qu’est-ce que voir de la danse ? Modalités d’une réception critique
Authors: Ayouti, Lauréat Prix APFUCC Thomas
Published: December 2018

Cet article a pour objectif d’explorer les diverses modalités qui viennent organiser la réception des œuvres chorégraphiques. Aussi si la question est massive – qu’est-ce que voir de la danse – l’enjeu est ici de poser des jalons en s’appliquant à la fois à développer une analyse théorique qui s’appuie sur la philosophie de Bergson tout en conservant un souci du réel. Le point de vue adopté est celui du spectateur et du critique. Trois moments de la réception sont développés : avant le spectacle, autour des concepts d’horizon d’attente et de coordonnées du regard ; pendant le spectacle, en interrogeant le passage de l’image à la représentation ; après le spectacle, en traitant des caractéristiques de la signification de l’œuvre chorégraphique.
Les représentations des pratiques sexuelles : du phallocentrisme au queer en passant par les réseaux sociaux
Authors: Brassard Christina , Chung Christina , Girard Guillaume
Published: December 2018

Les représentations des pratiques sexuelles : du phallocentrisme au queer en passant par les réseaux sociaux

Introduction au dossier.
Pratiques sexuelles et corps imaginaires dans l’œuvre de Pierre Molinier : l’auto-érotisme comme re présentation de soi
Authors: Marull Mélodie
Published: December 2018

La vie comme l’œuvre de Pierre Molinier sont liées dans la quête constante d’un état de plénitude assimilé à l’androgynie et à une sexualité libérée de toute contrainte. L’artiste opère incessamment une déconstruction et une reconstruction de son propre corps. Niant réalité anatomique et catégories de genre sexuel, il imagine des créatures désirantes qu’il incarne et raconte. Sa vie et son œuvre s’entremêlent dans une constante recherche de volupté et dans la satisfaction de ses désirs fétichistes, tournés vers les jambes et le travestissement.

En rejetant un système binaire et normatif, tant dans son existence et ses pratiques sexuelles que dans leur mode de représentation, Molinier construit un langage de l’intime et du corps, alliant mascarade et subversion, et érige la fluidité en tant que principe élémentaire. Les images et les discours qu’il produit apparaissent aujourd’hui comme précurseurs d’une conception queer de l’identité, des corps et des sexualités.
Le Nécrophile de Gabrielle Wittkop : la perversion, l’abjection et l’antirelationalité queer
Authors: Rémy-Handfield Gabriel
Published: December 2018

Cet article aborde le phénomène de la perversion dans le roman Le Nécrophile (1972) de l’écrivaine française Gabrielle Wittkop (1920-2002). Écrit sous la forme d’un journal intime, le roman plonge les lecteurs et les lectrices aux plus intimes des pensées, des désirs et des fantasmes du personnage principal, Lucien. En premier lieu, nous définissons la perversion à travers les idées de James Penney dans son ouvrage The World of Perversion : Psychoanalysis and the Impossible Absolute of Desire et à travers le concept de monde sans autrui défini par Gilles Deleuze dans Logique du sens (1969). De plus, cette fascination pour la perversion influence aussi certains théoriciens queer, comme Lee Edelman. À travers ce qu’on appelle le tournant antirelationnel, la perversion se rapproche de la théorie queer en raison de son caractère improductif qui permet d’échapper, ou du moins, de contourner le régime hétéronormatif.
Intégrer la typographie et la ponctuation à l’enseignement/apprentissage du FLE
Authors: Jeanmaire Guillaume , Kim Daeyoung
Published: December 2018

La typographie et la ponctuation ne semblent plus considérées avec autant d’importance aujourd’hui qu’autrefois, même au sein de l’enseignement. Outre qu’elles constituent une composante essentielle d’une langue, elles peuvent aussi en faciliter l’apprentissage. Mais compte tenu de la diversité des conventions d’une langue à une autre, il faut bien reconnaître qu’il est souvent difficile d’en faire apprécier les nuances. Les apprenants anglophones sont par exemple désarmés face à la typographie et à la ponctuation françaises, en particulier en raison des nombreuses différences entre l’anglais et le français, et ils ne sont pas les seuls, comme en témoignent les erreurs que nous avons fréquemment rencontrées auprès d’étudiants coréens ayant appris l’anglais en L2 depuis le collège, ainsi que d’étudiants d’échange anglophones canadiens et américains.
Acrylique sur toile
Authors: Serfas Shawn
Published: December 2018

Oeuvres (2018) de Shawn Serfas
Brigitte Meloche. Les impuissances. François B. Pelletier. Le chant du limon
Authors: Rouch Emma
Published: December 2018

Brigitte Meloche. Les impuissances.

François B. Pelletier. Le chant du limon

Compte rendu
Daniel H. Dugas et Valerie LeBlanc. Everglades
Authors: Parayre Catherine
Published: December 2018

Daniel H. Dugas et Valerie LeBlanc. Everglades

Compte rendu
Hédi Bouraoui. Les jumelles de l’oncle Sam
Authors: Rouch Emma
Published: December 2018

Hédi Bouraoui. Les jumelles de l’oncle Sam

Compte rendu