bluuebunny/crossref_metadata_2025 huggingface dataset:
Expression profile of ADAM10 and ADAM17 in allergic rhinitis
Authors: Chueh Hee Won , Park Seong Kook , Hur Dae Young , Bae Woo Yong
Published: August 2015

Background

A disintegrin and metalloprotease (ADAM) is a multifunctional gene family that contributes to the homeostasis of the extracellular matrix, transduction of specific intracellular signals, organogenesis, inflammation, tissue remodeling, adhesion, and cell migration. ADAM17 is the best characterized sheddase, with widespread putative substrates, including various inflammatory modulators. ADAM10 is the most similar ADAM to ADAM17 in terms of both protein sequence and the structural properties of their catalytic domains. The objective of this work was to assess the expression of ADAM10 and ADAM17 in allergic rhinitis to gain insight into their respective roles.

Methods

The expression of ADAM10 and ADAM17 was investigated in the nasal mucosa under allergic and nonallergic conditions. Tissue samples were evaluated by reverse‐transcription polymerase chain reaction (RT‐PCR) and Western blotting, and data were analyzed semiquantitatively with densitometry.

Results

The ADAM17 messenger RNA (mRNA) level was significantly (p < 0.001) lower in the allergic nasal mucosa than in the nonallergic nasal mucosa, whereas the ADAM10 mRNA level was significantly (p < 0.001) lower in the nonallergic nasal mucosa. The ADAM17 protein levels were also significantly (p < 0.001) lower in the allergic nasal mucosa, whereas the ADAM10 protein levels were lower in the nonallergic nasal mucosa (p = 0.002).

Conclusion

Decreased expression of ADAM17 and increased expression of ADAM10 may contribute to the development of allergic rhinitis through unknown pathways. We suggest that understanding the expression profile of ADAM17 and ADAM10 might help to elucidate the mechanism of allergic rhinitis.
Synthese und Festkörperstruktur eines Ga‐substituierten Distibens und eines Sb‐Analogons von Bicyclo[1.1.0]butan
Authors: Tuscher Lars , Ganesamoorthy Chelladurai , Bläser Dieter , Wölper Christoph , Schulz Stephan
Published: August 2015

RGa {R=HC[C(Me)N(2,6‐iPr2C6H3)]2} reagiert mit Sb(NMe2)3 unter Insertion in die Sb‐N‐Bindung und der Eliminierung von RGa(NMe2)2 (2), gefolgt von der Bildung eines Ga‐substituierten Distibens R(Me2N)GaSbSbGa(NMe2)R (1). Die Thermolyse von 1 verläuft unter Eliminierung von RGa und 2 und darauffolgend unter Bildung des Bicyclo[1.1.0]butan‐Analogons [R(Me2N)Ga]2Sb4 (3).
Growth of High‐Quality, Thickness‐Reduced Zeolite Membranes towards N2/CH4 Separation Using High‐Aspect‐Ratio Seeds
Authors: Huang Yi , Wang Lei , Song Zhuonan , Li Shiguang , Yu Miao
Published: August 2015

Greatly improved zeolite membranes were prepared by using high‐aspect‐ratio zeolite seeds. Slice‐shaped seeds with a high aspect ratio (AR) facilitated growth of thinner continuous SAPO‐34 membranes of much higher quality. These membranes showed N2 permeances as high as (2.87±0.15)×10−7 mol m−2 s−1 Pa−1 at 22 °C while maintaining a decent N2/CH4 selectivity (9–11.2 for equimolar mixture). On the basis of these thinner high‐quality SAPO‐34 membranes, fine‐tuning the local crystal structure by incorporating more silicon further increased the N2 permeance by 1.4 times without sacrificing the N2/CH4 selectivity. We expect that application of large AR zeolite seeds might be a viable strategy to grow thin high‐quality zeolite membranes. In addition, fine‐tuning of the crystal structure by changing the crystal composition might be a feasible way for further improving the separating performance of high‐quality zeolite membranes.
Seltenerdnitridophosphate durch Hochdruckmetathese
Authors: Kloß Simon David , Schnick Wolfgang
Published: August 2015

Die Erschließung eines großen Spektrums neuer Verbindungen durch eine neue Synthesemethode kann zu faszinierenden Entdeckungen führen. Hier berichten wir über die Synthese des ersten Seltenerdnitridophosphats, LiNdP4N8. Durch Festkörpermetathese zwischen LiPN2 und NdF3 wurde unter Hochdruck ein makrokristallines Produkt erhalten. Wir vermuten, dass in situ gebildetes LiF als thermodynamische Triebkraft und als Flux wirkt. Das Wachstum von für Kristallstrukturanalyse geeigneten Einkristallen wird durch den Flux unterstützt. Die von Nd3+ stammenden magnetischen Eigenschaften wurden mit SQUID‐Magnetometrie gemessen. LiNdP4N8 fungiert als Modellsystem für die Erforschung von Seltenerdnitridophosphaten, die möglicherweise auch auf Übergangsmetalle erweitert werden kann. Unsere Hochdruckmetathese ermöglicht die systematische Untersuchung der unbekannten Gebiete innerhalb nitridbasierter Materialien, die interessante Eigenschaften aufweisen können.
Biocatalytic Feedback‐Driven Temporal Programming of Self‐Regulating Peptide Hydrogels
Authors: Heuser Thomas , Weyandt Elisabeth , Walther Andreas
Published: August 2015

Switchable self‐assemblies respond to external stimuli with a transition between near‐equilibrium states. Although being a key to present‐day advanced materials, these systems respond rather passively, and do not display autonomous dynamics. For autonomous behavior, approaches must be found to orchestrate the time domain of self‐assemblies, which would lead to new generations of dynamic and self‐regulating materials. Herein, we demonstrate catalytic control of the time domain of pH‐responsive peptide hydrogelators in a closed system. We program transient acidic pH states by combining a fast acidic activator with the slow, enzymatic, feedback‐driven generation of a base (dormant deactivator). This transient state can be programmed over orders of magnitude in time. It is coupled to dipeptides to create autonomously self‐regulating, dynamic gels with programmed lifetimes, which are used for fluidic guidance, burst release, and self‐erasing rapid prototyping.
Oxovanadium(IV), copper(II) or cobalt(II) acetylacetone complexes immobilized on amino‐functionalized CMK‐3 for the aerobic epoxidation of styrene
Authors: Wang Xiufang , Wu Shujie , Li Zhifang , Yang Xiaoyuan , Hu Jing , Huo Qisheng , Guan Jingqi , Kan Qiubin
Published: August 2015

Oxovanadium(IV), copper(II) and cobalt(II) acetylacetone complexes have been grafted onto amino‐modified CMK‐3‐O (VO‐NH2‐CMK‐3, Cu‐NH2‐CMK‐3 and Co‐NH2‐CMK‐3,respectively) and the materials thus prepared were used as heterogeneous catalysts for the aerobic oxidation of styrene. X‐ray diffraction, nitrogen adsorption–desorption and transmission electron microscopy measurements confirmed the structural integrity of the mesoporous hosts, and spectroscopic characterization techniques (Fourier transform infrared, X‐ray photoelectron, Raman) and thermogravimetry confirmed the ligands and the successful anchoring of the acetylacetone complexes to the modified mesoporous support. VO‐NH2‐CMK‐3 displayed a relatively good catalytic performance with 94.6% of styrene conversion using air as oxidant, while Cu‐NH2‐CMK‐3 gave 99.6% of styrene conversion using tert‐butyl hydroperoxide as oxidant. Copyright © 2015 John Wiley & Sons, Ltd.
Synthesis and characterization of copper(II) Schiff base complex supported on Fe3O4 magnetic nanoparticles: a recyclable catalyst for the one‐pot synthesis of 2,3‐dihydroquinazolin‐4(1H)‐ones
Authors: Ghorbani‐Choghamarani Arash , Darvishnejad Zahra , Norouzi Masoomeh
Published: August 2015

Fe3O4–Schiff base of Cu(II) is found to be a recyclable and heterogeneous catalyst for the rapid and efficient synthesis of various 2,3‐dihydroquinazolin‐4(1H)‐one derivatives from the two‐component condensation of 2‐aminobenzamide and an aldehyde. This reaction is simple, green and cost‐effective. Separation and recycling can also be easily done by magnetic decantation of the Fe3O4 nanoparticles with an external magnet. The prepared catalyst was characterized using thermogravimetry, Fourier transform infrared spectroscopy, vibrating sample magnetometry, inductively coupled plasma analysis, X‐ray diffraction and scanning electron microscopy. Copyright © 2015 John Wiley & Sons, Ltd.
3‐(Diphenylphosphino)propanoic acid: an efficient ligand for the Pd/Cu‐catalyzed homo‐coupling of terminal alkynes in the presence of oxygen at room temperature
Authors: Liu Yashuai , Gu Ningning , Liu Ping , Xie Jianwei , Ma Xiaowei , Liu Yan , Dai Bin
Published: August 2015

A simple, yet efficient system for PdCl2/CuI to catalyze the homo‐coupling reactions of various terminal alkynes has been developed using 3‐(diphenylphosphino)propanoic acid as ligand in the presence of oxygen. The alkynes, including aromatic, heteroaromatic and aliphatic alkynes, were transformed at room temperature into the corresponding 1,3‐diynes in moderate to excellent yields. The turnover number was up to 1.04 × 103. Copyright © 2015 John Wiley & Sons, Ltd.
IgG Subclass Specificity Discriminates Restricted IgM Rheumatoid Factor Responses From More Mature Anti–Citrullinated Protein Antibody–Associated or Isotype‐Switched IgA Responses
Authors: Falkenburg Willem J. J. , van Schaardenburg Dirkjan , Ooijevaar‐de Heer Pleuni , Wolbink Gertjan , Rispens Theo
Published: August 2015

Objective

To investigate the presence and patterns of specific IgG subclass recognition by IgM rheumatoid factor (IgM‐RF) and IgA‐RF with a newly developed enzyme‐linked immunosorbent assay (ELISA), which can discriminate between polyspecific and restricted RF responses.

Methods

Polyspecific and restricted RF responses were determined with our ELISA, which uses individually coated recombinant IgG subclasses instead of polyclonal IgG as target antibodies. Fine specificity was determined using target antibodies with single amino acid mutations in the Fc region.

Results

In a screening panel of 93 sera that were previously found to be IgM‐RF positive in a conventional RF assay, we were able to discriminate between sera with polyspecific IgM‐RF responses (i.e., RF responses directed against all 4 IgG subclasses) and those with restricted IgM‐RF responses, with low or absent relative reactivity against IgG2, IgG3, or IgG4. We found the largest variation for anti‐IgG3 reactivity. Samples without detectable anti‐IgG4 reactivity formed an independent group from the other restricted RF responses and the polyspecific RF responses. The specificity of these anti‐IgG4–negative sera could be pinpointed to single amino acid differences between IgG1 and IgG4. Polyspecific RF responses more often showed signs of RF response maturation, with more isotype switching to IgA‐RF, as compared to restricted RF responses. In a cohort of IgM‐RF+ and/or anti–citrullinated protein antibody (ACPA)–positive arthralgia patients, we found restricted RF responses in 35% (49 of 140) of RF+/ACPA– patients, while RF+/ACPA+ patients, who have a much higher risk of developing rheumatoid arthritis, virtually always (123 of 128 [96%]) showed a polyspecific RF response.

Conclusion

IgG subclass–specific RF distinguishes between immature restricted RF responses and potentially more pathogenic, ACPA‐associated polyspecific responses.
Brief Report: Lack of Replication of an Association Between Anti–Citrullinated Fibrinogen and Subclinical Atherosclerosis in Patients With Rheumatoid Arthritis
Authors: Montes Ariana , Corrales Alfonso , Calaza Manuel , Lopez‐Mejias Raquel , Parra Jose A. , González‐Gay Miguel A. , González Antonio
Published: August 2015

Objective

Results of a recent study suggested that the excess cardiovascular (CV) risk observed in patients with rheumatoid arthritis (RA) could be partially explained by the presence of immune complexes of antibodies against citrullinated proteins that locally promote and perpetuate inflammation and progression of atherosclerotic plaques. The present study was undertaken to attempt to replicate one of the observations supporting this hypothesis, i.e., association between anti–citrullinated fibrinogen (anti–Cit‐fibrinogen) positivity and subclinical atherosclerosis.

Methods

Three surrogate markers of atherosclerosis were assessed in 124 RA patients with no previous history of CV events: carotid intima‐media thickness (CIMT) assessed by carotid ultrasonography, carotid plaques assessed by carotid ultrasonography, and Coronary Artery Calcification Score (CACS) determined by multidetector computed tomography (CT) scanning. We analyzed the relationship of these 3 subclinical atherosclerosis markers to the presence and levels of autoantibodies, including anti–Cit‐fibrinogen, anti–cyclic citrullinated peptide 2 (anti–CCP‐2), and rheumatoid factor (RF).

Results

Carotid plaques and CIMT >0.90 mm were present in 69.4% and 15.3%, of the patients, respectively, and the CACS was moderate or high in 21.0%. None of these surrogate markers of atherosclerosis showed a significant association with positivity for or the level of anti–Cit‐fibrinogen antibodies (either against the whole protein [present in 33.9% of the patients] or against an immunodominant peptide [present in 23.4%]), anti–CCP‐2 (present in 60.7%), or RF (present in 58.1%) in this series of patients with RA.

Conclusion

Our results do not support the notion that there is a relationship between anti–Cit‐fibrinogen antibodies and subclinical atherosclerosis in RA, thus calling into question the claim that these antibodies have a role in the increased risk of CV disease observed in patients with RA.
Rhodium(II)‐Catalyzed Annulation of Azavinyl Carbenes Through Ring‐Expansion of 1,3,5‐Trioxane: Rapid Access to Nine‐Membered 1,3,5,7‐Trioxazonines
Authors: Pospech Jola , Ferraccioli Raffaella , Neumann Helfried , Beller Matthias
Published: August 2015

The rhodium(II)‐catalyzed denitrogenative coupling of N‐alkylsulfonyl 1,2,3‐triazoles with 1,3,5‐trioxane led to nine‐membered‐ringed trioxazonines in moderate‐to‐good yields. 1,3,5‐Trioxane, acting as an oxygen nucleophile, reacted with the α‐aza‐vinylcarbene intermediate, giving rise to ylide formation, which was probably the key step in the reaction. Triazoles that contained aryl substituents with various electronic and steric features on the C4 carbon atom were well‐tolerated. The synthesis of trioxazonine derivatives was achieved through a one‐pot, two‐step procedure from 1‐mesylazide and a terminal alkyne by combining CuI‐catalyzed 1,3‐dipolar cycloaddition and rhodium‐catalyzed transformations.
Bifunctional Perovskite Oxide Catalysts for Oxygen Reduction and Evolution in Alkaline Media
Authors: Gupta Shiva , Kellogg William , Xu Hui , Liu Xien , Cho Jaephil , Wu Gang
Published: August 2015

Oxygen electrocatalysis, namely of the oxygen reduction reaction (ORR) and the oxygen evolution reaction (OER), governs the performance of numerous electrochemical energy systems such as reversible fuel cells, metal–air batteries, and water electrolyzers. However, the sluggish kinetics of these two reactions and their dependency on expensive noble metal catalysts (e.g, Pt or Ir) prohibit the sustainable commercialization of these highly innovative and in‐demand technologies. Bifunctional perovskite oxides have emerged as a new class of highly efficient non‐precious metal catalysts (NPMC) for oxygen electrocatalysis in alkaline media. In this review, we discuss the state‐of‐the‐art understanding of bifunctional properties of perovskites with regards to their OER/ORR activity in alkaline media and review the associated reaction mechanisms on the oxides surface and the related activity descriptors developed in the recent literature. We also summarize the present strategies to modify their electronic structure and to further improve their performance for the ORR/OER through highlighting the new concepts relating to the role of surface redox chemistry and oxygen deficiency of perovskite oxides for the ORR/OER activity. In addition, we provide a brief account of recently developed advanced perovskite–nanocarbon hybrid bifunctional catalysts with much improved performances.
Microwave‐Assisted Hydrothermal Rapid Synthesis of Amorphous Calcium Phosphate Mesoporous Microspheres Using Adenosine 5′‐Diphosphate and Application in pH‐Responsive Drug Delivery
Authors: Qi Chao , Zhu Ying‐Jie , Sun Tuan‐Wei , Wu Jin , Chen Feng
Published: August 2015

Herein we report a rapid and green strategy for the preparation of amorphous calcium phosphate mesoporous microspheres (ACP‐MSs) using adenosine 5′‐diphosphate disodium salt (ADP) as an organic phosphorus source by a microwave‐assisted hydrothermal method. The effects of the pH value, the reaction time, and temperature on the crystal phase and morphology of the product are investigated. The ADP biomolecules used in this strategy play an important role in the formation of ACP‐MSs. The as‐prepared ACP‐MSs are efficient for anticancer drug delivery by using doxorubicin (Dox) as a model drug, and the Dox‐loaded ACP‐MSs show a high ability to damage cancer cells. Moreover, the ACP‐MSs drug delivery system exhibits a pH‐responsive drug‐release behavior due to the degradation of ACP‐MSs at a low pH value, thus, it is promising for applications in pH‐responsive drug delivery.
Exploring Sustainable Rocket Fuels: [Imidazolyl−Amine−BH2]+‐Cation‐Based Ionic Liquids as Replacements for Toxic Hydrazine Derivatives
Authors: Huang Shi , Qi Xiujuan , Zhang Wenquan , Liu Tianlin , Zhang Qinghua
Published: August 2015

The application of hypergolic ionic liquids as propellant fuels is a newly emerging area in the fields of chemistry and propulsion science. Herein, a new class of [imidazolyl−amine−BH2]+‐cation‐based ionic liquids, which included fuel‐rich anions, such as dicyanamide (N(CN)2−) and cyanoborohydride (BH3CN−) anions, were synthesized and characterized. As expected, all of the ionic liquids exhibited spontaneous combustion upon contact with the oxidizer 100 % HNO3. The densities of these ionic liquids varied from 0.99–1.12 g cm−3, and the heats of formation, predicted based on Gaussian 09 calculations, were between −707.7 and 241.8 kJ mol−1. Among them, the salt of compound 5, that is, (1‐allyl‐1H‐imidazole‐3‐yl)−(trimethylamine)−dihydroboronium dicyanamide, exhibited the lowest viscosity (168 MPa s), good thermal properties (Tg<−70 °C, Td>130 °C), and the shortest ignition‐delay time (18 ms) with 100 % HNO3. These ionic fuels, as “green” replacements for toxic hydrazine‐derivatives, may have potential applications as bipropellant formulations.
Differential Effects of Polymer‐Surface Decoration on Drug Delivery, Cellular Retention, and Action Mechanisms of Functionalized Mesoporous Silica Nanoparticles
Authors: You Yuanyuan , Hu Hao , He Lizhen , Chen Tianfeng
Published: August 2015

Polymer‐surface decoration has been found to be an effective strategy to enhance the biological activities of nanomedicine. Herein, three different types of polymers with a cancer‐targeting ligand Arg‐Gly‐Asp peptide (RGD) have been used to decorate mesoporous silica nanoparticles (MSNs) and the functionalized nanosystems were used as drug carriers of oxaliplatin (OXA). The results showed that polymer‐surface decoration of the MSNs nanosystem by poly(ethylene glycol) (PEG) and polyethyleneimine (PEI) significantly enhanced the anticancer efficacy of OXA, which was much higher than that of chitosan (CTS). This effect was closely related to the enhancement of the cellular uptake and cellular drug retention. Moreover, PEI@MSNs‐OXA possessed excellent advantages in penetrating ability and inhibitory effects on SW480 spheroids that were used to simulate the in vivo tumor environments. Therefore, this study provides useful information for the rational design of a cancer‐targeted MSNs nanosystem with polymer‐surface decoration.
Associations between tropical cyclone activity in the Southwest Indian Ocean and El Niño Southern Oscillation
Authors: Astier Nicolas , Plu Matthieu , Claud Chantal
Published: August 2015

The link between El Niño Southern Oscillation (ENSO) and tropical cyclone activity over the Southwest Indian Ocean [(0°–30°S) × (48°–90°E)] is revisited. Based on the records for 1981–2013, we show that cyclonic activity decreases dramatically during strong ENSO events: only a few cases are observed during the January‐March period. This pattern is attributed to changes in large‐scale thermodynamic parameters. Although El Niño is correlated with an increase in tropospheric moisture and sea‐surface temperatures, it is also associated with an equatorward shift of the subtropical jet. When El Niño is sufficiently strong, the latter effect may dominate the former, inhibiting tropical cyclone activity.
Thundersnow in Brazil: a case study of 22 July 2013
Authors: Dolif Neto Giovanni , Market Patrick S. , Pezza Alexandre Bernardes , Morales Rodriguez Carlos Augusto , Calvetti Leonardo , da Silva Dias Pedro Leite , Escobar Gustavo Carlos Juan
Published: August 2015

On 23 July 2013, a snowstorm hit southern Brazil causing material damage and two deaths. Radar reflectivity and lightning data revealed a rare thundersnow occurrence. This study revealed that a Rossby wave propagation followed a typical pattern of cold incursions in South America, but some fundamental differences can be pointed out: (1) further northward Rossby wave amplification; (2) strong upward vertical motion within a deep nearly saturated layer and (3) a conditional symmetric instability layer, in response to strong vertical shear, beneath a layer of weak conditional instability, and above a significant near‐surface vertical depth where temperatures hover around 0 °C.
Issues involved in the phenotypic classification of orofacial clefts ascertained through a state birth defects registry for the north carolina cleft outcomes study
Authors: Aylsworth Arthur S. , Allori Alexander C. , Pimenta Luiz A. , Marcus Jeffrey R. , Harmsen Katherine G. , Watkins Stephanie E. , Ramsey Barry L. , Strauss Ronald P. , Meyer Robert E.
Published: August 2015

Background: Epidemiologic studies involving birth defects are extremely sensitive to phenotype accuracy and precision. We devised a case review and classification protocol for a project to study school achievement in children with idiopathic, nonsyndromic orofacial clefts to improve the reliability of phenotypic classification from the statewide birth defects registry. Methods: Surveillance‐program abstraction data and medical records at the birth or treating hospitals were used when available. Exclusion criteria included: median cleft lip; Tessier cleft; premaxillary agenesis; presence of a recognizable syndrome, phenotype, association, or sequence (other than Robin sequence); clefts with other malformations not considered to be normal or common variants in the newborn; and cases with documented or suspected genetic or teratogenic causes. Results: Of 712 children identified with orofacial clefts, 153 were excluded, leaving 559 nonsyndromic orofacial cleft cases of unknown cause in the final study. These cases were grouped into the following clinically meaningful types: cleft lip with or without cleft alveolus; cleft lip and cleft palate; and cleft palate only. This review and classification process resulted in the elimination of 21.5% of the original cohort of identified cases, with most exclusions being due to suspected syndromic associations. Conclusion: Verbatim descriptions of the clinical findings are critical for accurate classification of diagnoses. This review process improved the precision of orofacial cleft phenotype classification for our study. Precision would have been further improved if all of the cases had verbatim descriptions of diagnoses and all medical records could have been reviewed by the classification team. Birth Defects Research (Part A) 103:899–903, 2015. © 2015 Wiley Periodicals, Inc.
Noncoding RNAs and chronic inflammation: Micro‐managing the fire within
Authors: Alexander Margaret , O'Connell Ryan M.
Published: August 2015

Inflammatory responses are essential for the clearance of pathogens and the repair of injured tissues; however, if these responses are not properly controlled chronic inflammation can occur. Chronic inflammation is now recognized as a contributing factor to many age‐associated diseases including metabolic disorders, arthritis, neurodegeneration, and cardiovascular disease. Due to the connection between chronic inflammation and these diseases, it is essential to understand underlying mechanisms behind this process. In this review, factors that contribute to chronic inflammation are discussed. Further, we emphasize the emerging roles of microRNAs (miRNAs) and other noncoding RNAs (ncRNA) in regulating chronic inflammatory states, making them important future diagnostic markers and therapeutic targets. Copyright Line: © 2015 The Authors BioEssays Published by Wiley‐VCH Verlag GmbH & Co. KGaA.
Review and Discussion of Strategies to Address Low Trainer‐to‐Staff Ratios
Authors: Karsten Amanda M. , Axe Judah B. , Mann Charlotte C.
Published: August 2015

Researchers have developed an array of highly adaptable intervention packages with well‐documented efficacy for staff and teacher training. As indicated by Parsons, Rollyson, and Reid (2012) in their article on best practices in staff training, behavior analysts must use methods that are both effective and efficient given the limited resources of many human service settings (e.g., low trainer‐to‐staff ratios). The purpose of this paper is to summarize research on practical innovations for staff and teacher training, including the use of video‐based technology and self‐instruction materials that may help trainers to operate effectively despite limited time and personnel. Results are discussed in terms of the current state of the evidence for each practical innovation and considerations for integrating these strategies with best practices in staff training. Copyright © 2015 John Wiley & Sons, Ltd.
Spectra, stability and labeling of 1‐(5‐carboxypentyl)‐4‐(2‐(N‐ethyl‐carbazole‐3‐yl) vinyl) pyridinium bromide with a large Stokes shift
Authors: Gu Yingchun , Lin Dayong , Li Ran , Tang Yalin , Fei Xuening , Zhou Jianguo
Published: August 2015

Carbazole and its derivatives have been widely utilized as a functional building block in the fabrication of the organic medicine, pesticides, materials, etc., because of their excellent solubility, stability and biological activity. In this paper, 1‐(5‐carboxypentyl)‐4‐(2‐(N‐ethyl‐carbazole‐3‐yl) vinyl) pyridinium bromide with a large Stokes shift was synthesized and characterized by 1H NMR and MS. The UV/vis absorption and fluorescence spectra in different solvents and at different pH values were investigated preliminarily. The photostability and thermostability were also studied and the results showed that the compound was stable. The compound was also used to label bovine serum albumin (BSA) and calf thymus (ct)DNA. The results showed that the fluorescence intensity is enhanced when labeling with BSA and the binding ability is stronger than ctDNA, making it may be used as a biological probe. Copyright © 2015 John Wiley & Sons, Ltd.
Tunable emission, energy transfer and charge compensation in SrMoO4:Sm3+,Tb3+,Na+ phosphor
Authors: Cao Renping , Chen Kangbin , Jiang Shenhua , Luo Zhiyang , Yu Xiaoguang , Liu Pan
Published: August 2015

A series of SrMoO4:Sm3+,Tb3+,Na+ phosphors was synthesized using a high‐temperature solid‐state reaction method in air. On excitation at 290 nm, SrMoO4:Sm3+,Tb3+ phosphor emitted light that varied systematically from green to reddish‐orange on changing the Sm3+ and Tb3+ ion concentrations. The emission intensities of SrMoO4:Sm3+ and SrMoO4:Sm3+,Tb3+ phosphors were increased two to four times due to charge compensation when Na+ was added as a charge compensator. The luminescence mechanism and energy transfer could be explained using energy‐level diagrams of the MoO42– group, Sm3+ and Tb3+ ions. SrMoO4:Sm3+,Tb3+,Na+ could be used as reddish‐orange phosphor in white light‐emitting diodes (LEDs) based on an ~ 405 nm near‐UV LED chip. This research is helpful in adjusting and improving the luminescence properties of other phosphors. Copyright © 2015 John Wiley & Sons, Ltd.
Toward intrinsically colored peptides: Synthesis and investigation of the spectral properties of methylated azatryptophans in tryptophan‐cage mutants
Authors: Noichl Benjamin P. , Durkin Patrick M. , Budisa Nediljko
Published: August 2015

Tryptophan has been taken as the basic scaffold for a chromophore whose indole residue can be further functionalized by the introduction of endocyclic nitrogen atoms or by N‐methylation. When compared with exocyclic modifications, modifying tryptophan in an endocyclic fashion (through atomic substitution) should not perturb the steric profile of the amino acid side chain to such a large extent as that of an exocyclic modification, while simultaneously modulating the polarity, hydrogen‐bonding ability, and spectral properties of the amino acid. Of particular interest is that the spectral properties can be tailored such that the chromophore can be monitored at wavelengths that exceed natural protein fluorescence. Ideally, the optimum excitation wavelength should be between 300 and 350 nm, and the emission wavelength should be ≥500 nm such that no cross‐excitation/fluorescence occurs. Here, we report the synthesis of amino acid labels that exhibit large red shifts in their fluorescence profiles and their use in peptides. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 585–600, 2015.
Learning nucleic acids solving by bioinformatics problems
Authors: Nunes Rhewter , Barbosa de Almeida Júnior Edivaldo , Pessoa Pinto de Menezes Ivandilson , Malafaia Guilherme
Published: August 2015

The article describes the development of a new approach to teach molecular biology to undergraduate biology students. The 34 students who participated in this research belonged to the first period of the Biological Sciences teaching course of the Instituto Federal Goiano at Urutaí Campus, Brazil. They were registered in Cell Biology in the first semester of 2013. They received four 55 min‐long expository/dialogued lectures that covered the content of “structure and functions of nucleic acids”. Later the students were invited to attend four meetings (in a computer laboratory) in which some concepts of Bioinformatics were presented and some problems of the Rosalind platform were solved. The observations we report here are very useful as a broad groundwork to development new research. An interesting possibility is research into the effects of bioinformatics interventions that improve molecular biology learning. © 2015 by The International Union of Biochemistry and Molecular Biology, 43(5):377–383, 2015.
2015 ACC/HRS/SCAI Left Atrial Appendage Occlusion Device Societal Overview: A professional societal overview from the American College of Cardiology, Heart Rhythm Society, and Society for Cardiovascular Angiography and Interventions
Authors: Masoudi Frederick A. , Calkins Hugh , Kavinsky Clifford J. , Slotwiner David J. , Turi Zoltan G. , Drozda Joseph P. , Gainsley Phillip
Published: August 2015

TABLE OF CONTENTS

Preamble2

1. Introduction2

1.1. Key Questions3

2. Stroke Prevention in AF: Current Evidence and Guidelines3

3. Literature Review4

3.1. Background4

3.2. WATCHMAN4

3.3. Amplatzer Cardiac Plug7

3.4. LARIAT7

3.5. Other Percutaneous Devices and Surgical Approaches8

4. Care Team and Facilities8

4.1. Multidisciplinary Heart Team8

4.2. General Requirements9

4.3. Facilities9

5. Operator Training10

6. Protocols for Care10

7. Assessment of Patient Selection and Outcomes10

Appendix 1. Relevant Author Relationships With Industry and Other Entities–ACC/HRS/SCAI Left Atrial Appendage Occlusion Device Societal Overview14

Appendix 2. Reviewer Relationships With Industry And Other Entities–2015 ACC/HRS/SCAI Left Atrial Appendage Occlusion Device Societal Overview15
Chitosan Waste‐Derived Co and N Co‐doped Carbon Electrocatalyst for Efficient Oxygen Reduction Reaction
Authors: Xie Shilei , Huang Senchuan , Wei Wenjie , Yang Xinzhe , Liu Yi , Lu Xihong , Tong Yexiang
Published: August 2015

To achieve optimal performance of fuel cells and metal‐air batteries, searching the cost‐effective catalysts with enhanced activity and durability for oxygen reduction reaction (ORR) is highly pursued. We present a new and scalable approach to synthesize low‐cost Co and N co‐doped C (CoNC) catalysts from sustainable organic‐rich chitosan waste. The CoNC designed here involves in chelation between the chitosan and Co ions, shows superior ORR activity. The XPS spectra demonstrate the kinds of ORR active N sites are of high content in the CoNC, which lead to preferable catalytic activity. The TEM images show more highly dispersion of Co, N and C in the CoNC, which contributes to the high ORR activity. The CoNC catalysts exhibit a remarkable limiting current of ∼5.36 mA cm−2 and positive onset potential of −0.105 V (vs. Ag/AgCl), both of which are comparable to those of the commercial Pt/C. Additionally, the optimal CoNC also possesses prominent durability and tolerance of methanol.
Metadynamics Simulations Rationalise the Conformational Effects Induced by N‐Methylation of RGD Cyclic Hexapeptides
Authors: Paissoni Cristina , Ghitti Michela , Belvisi Laura , Spitaleri Andrea , Musco Giovanna
Published: August 2015

We combined metadynamics, docking and molecular mechanics/generalised born surface area (MM/GBSA) re‐scoring methods to investigate the impact of single and multiple N‐methylation on a set of RGD cyclopeptides displaying different affinity for integrin αIIbβ3. We rationalised the conformational effects induced by N‐methylation and its interplay with receptor affinity, obtaining good agreement with experimental data. This approach can be exploited before entering time‐consuming and expensive synthesis and binding experiments.
Spin Crossover and Valence Tautomerism in Neutral Homoleptic Iron Complexes of Bis(pyridylimino)isoindolines
Authors: Scheja Anne , Baabe Dirk , Menzel Dirk , Pietzonka Clemens , Schweyen Peter , Bröring Martin
Published: August 2015

Homoleptic iron complexes of six bis(pyridylimino)isoindoline (bpi) ligands with different substituents (H, Me, Et, tBu, OMe, NMe2) at the 4‐positions of the pyridine moieties have been prepared and studied with regard to temperature‐dependent spin and redox states by a combination of 57Fe Mössbauer spectroscopy, SQUID magnetometry, single‐crystal X‐ray diffraction analysis, X‐band EPR, and 1H NMR spectroscopy. While the H‐, methyl‐, and ethyl‐substituted complexes remain in a pure high‐spin state irrespective of the temperature, the 4‐tert‐butyl‐substituted derivative shows spin‐crossover behavior. The methoxy‐ and dimethylamino‐substituted compounds were found to easily undergo oxidation. In the crystalline state, valence tautomeric behavior was observed for the methoxy derivative as a thermally activated charge‐transfer transition, accompanied by a spin crossover above 200 K. The valence tautomerism leads to a chelate with one of the bpi ligands as a dianion radical L2−. and with an effective spin of S=2.
Neutral and Cationic Molybdenum Imido Alkylidene N‐Heterocyclic Carbene Complexes: Reactivity in Selected Olefin Metathesis Reactions and Immobilization on Silica
Authors: Sen Suman , Schowner Roman , Imbrich Dominik A. , Frey Wolfgang , Hunger Michael , Buchmeiser Michael R.
Published: August 2015

The synthesis and single‐crystal X‐ray structures of the novel molybdenum imido alkylidene N‐heterocyclic carbene complexes [Mo(N‐2,6‐Me2C6H3)(IMesH2)(CHCMe2Ph)(OTf)2] (3), [Mo(N‐2,6‐Me2C6H3)(IMes)(CHCMe2Ph)(OTf)2] (4), [Mo(N‐2,6‐Me2C6H3)(IMesH2)(CHCMe2Ph)(OTf){OCH(CF3)2}] (5), [Mo(N‐2,6‐Me2C6H3)(CH3CN)(IMesH2)(CHCMe2Ph)(OTf)]+ BArF− (6), [Mo(N‐2,6‐Cl2C6H3)(IMesH2)(CHCMe3)(OTf)2] (7) and [Mo(N‐2,6‐Cl2C6H3)(IMes)(CHCMe3)(OTf)2] (8) are reported (IMesH2=1,3‐dimesitylimidazolidin‐2‐ylidene, IMes=1,3‐dimesitylimidazolin‐2‐ylidene, BArF−=tetrakis‐[3,5‐bis(trifluoromethyl)phenyl] borate, OTf=CF3SO3−). Also, silica‐immobilized versions I1 and I2 were prepared. Catalysts 3–8, I1 and I2 were used in homo‐, cross‐, and ring‐closing metathesis (RCM) reactions and in the cyclopolymerization of α,ω‐diynes. In the RCM of α,ω‐dienes, in the homometathesis of 1‐alkenes, and in the ethenolysis of cyclooctene, turnover numbers (TONs) up to 100 000, 210 000 and 30 000, respectively, were achieved. With I1 and I2, virtually Mo‐free products were obtained (<3 ppm Mo). With 1,6‐hepta‐ and 1,7‐octadiynes, catalysts 3, 4, and 5 allowed for the regioselective cyclopolymerization of 4,4‐bis(ethoxycarbonyl)‐1,6‐heptadiyne, 4,4‐bis(hydroxymethyl)‐1,6‐heptadiyne, 4,4‐bis[(3,5‐diethoxybenzoyloxy)methyl]‐1,6‐heptadiyne, 4,4,5,5‐tetrakis(ethoxycarbonyl)‐1,7‐octadiyne, and 1,6‐heptadiyne‐4‐carboxylic acid, underlining the high functional‐group tolerance of these novel Group 6 metal alkylidenes.
Design of BODIPY Dyes as Photosensitisers in Multicomponent Catalyst Systems for Light‐Driven Hydrogen Production
Authors: Dura Laura , Ahrens Johannes , Pohl Marga‐Martina , Höfler Sebastian , Bröring Martin , Beweries Torsten
Published: August 2015

A study of visible‐light‐driven hydrogen production using a multicomponent system consisting of different boron dipyrromethene (BODIPY) dyes, triethylamine and [{Pd(PPh3)Cl2}2] from THF/water mixtures is presented. A trio of meso‐mesityl BODIPY dyes display the best activities and long‐term stabilities of more than ten days with the 2,6‐diiodo derivative showing the best performance.
A General Access to Propargylic Ethers through Brønsted Acid Catalyzed Alkynylation of Acetals and Ketals with Trifluoroborates
Authors: Baxter Matthew , Bolshan Yuri
Published: August 2015

A general Brønsted acid catalyzed methodology for the alkynylation of acetals and ketals with alkynyltrifluoroborate salts has been developed. The reaction proceeds rapidly to afford valuable synthetic building block propargylic ethers in good to excellent yields. Unlike Lewis acid catalyzed transformations of trifluoroborates, this approach does not proceed via unstable organodifluoroborane intermediate. As a result, the developed methodology features excellent functional group tolerance and good atom economy.
ChemInform Abstract: Synthesis, Crystal Structure, and Vibrational Spectroscopy of the Alkali Diselenates A2Se2O7 (A: Li—Cs).
Authors: Daub Michael , Hillebrecht Harald
Published: August 2015

The title compounds are prepared by reaction of M2CO3 (M: Li, K, Rb, Cs) with an excess of H2SeO4 (silica crucible, 573 K, 2 d).
ChemInform Abstract: Ultralow‐Fatigue Shape Memory Alloy Films.
Authors: Chluba Christoph , Ge Wenwei , Lima de Miranda Rodrigo , Strobel Julian , Kienle Lorenz , Quandt Eckhard , Wuttig Manfred
Published: August 2015

Ultralow‐fatigue Ti54Ni34Cu12 shape memory alloy films allow at least 10 million transformation cycles.
ChemInform Abstract: Green Luminescence of Divalent Europium in the Hydride Chloride EuHCl.
Authors: Kunkel Nathalie , Rudolph Daniel , Meijerink Andries , Rommel Stefan , Weihrich Richard , Kohlmann Holger , Schleid Thomas
Published: August 2015

Olive‐green single crystals of EuHCl are prepared by reaction of Eu powder, NaH, and NaCl in a molar ratio of 1:1:1 (Nb capsule, 900 °C, 13 h).
ChemInform Abstract: Mesoporous CexCo1‐xCr2O4 Spinels: Synthesis, Characterization and Catalytic Application in Simultaneous Removal of Soot Particulate and NO.
Authors: Niu Xiaowei , Zhou Liang , Hu Xiaojun , Han Wei
Published: August 2015

The title catalysts (x = 0‐0.15) are prepared via combustion of stoichiometric aqueous solutions of the metal nitrates and urea in air and subsequent calcination (600 °C, 4 h).
ChemInform Abstract: Hydrothermal Synthesis and Dehydration of CaTeO3(H2O): An Original Route to Generate New CaTeO3 Polymorphs.
Authors: Poupon Morgane , Barrier Nicolas , Petit Sebastien , Clevers Simon , Dupray Valerie
Published: August 2015

CaTeO3(H2O) is prepared by microwave‐assisted hydrothermal reaction of Ca(NO3)2, TeO2, NaOH, and H2O (microwave furnace, autoclave, 185 °C, 1 h).
ChemInform Abstract: Cs6RE2(PO4)4 (RE: Y and Gd): Two New Members of the Alkali Rare‐Earth Double Phosphates.
Authors: Wang Ying , Lian Zhipeng , Su Xin , Yang Zhihua , Pan Shilie , Yan Qingfeng , Zhang Fangfang
Published: August 2015

Ce‐doped (0.01 mol%) polycrystalline Cs6Y2(PO4)4 (I) and Cs6Gd2(PO4)4 (II) are prepared by solid‐state reaction of stoichiometric amounts of Cs2CO3, Y2O3 (Gd2O3), CeO2, and NH4H2PO4 (CO atmosphere, alumina crucible, 750 °C, 40 h).
ChemInform Abstract: Synthesis, Crystal Structure, and Photoelectric Properties of a New Layered Bismuth Oxysulfide.
Authors: Meng Sha , Zhang Xian , Zhang Ganghua , Wang Yaoming , Zhang Hui , Huang Fuqiang
Published: August 2015

The new compound Bi9O7.5S6 is hydrothermally synthesized from Bi(NO3)3, thiourea, KOH, and LiOH dissolved in a 1:1 mixture of H2O and EtOH (autoclave, 180 °C, 72 h).
ChemInform Abstract: Template‐Dependent Photochemical Reactivity of Molecular Metal Oxides.
Authors: Tucher Johannes , Peuntinger Katrin , Margraf Johannes T. , Clark Timothy , Guldi Dirk M. , Streb Carsten
Published: August 2015

Single crystals of Bu4N [(Bi(dmso)3)2V12O33X] ·xDMSO (X: Cl (I), Br (II)) are prepared by dissolving (Bu4N)3[H3V10O28], Bi(NO3)2, and NaX in aqueous DMSO at 80 °C followed by addition of Bu4NOH (80 °C, 1 h, 67 and 71% yield, resp.).
ChemInform Abstract: Remote Substituent Effects on the Stereoselectivity and Organocatalytic Activity of Densely Substituted Unnatural Proline Esters in Aldol Reactions.
Authors: Cossio Fernando P. , et al.
Published: August 2015

Densely substituted proline esters are prepared by asymmetric [3+2] cycloadditions of azomethine ylides derived from glycine iminoesters.
ChemInform Abstract: Enantioselective Synthesis of 1,2‐Dihydronaphthalene‐1‐carbaldehydes by Addition of Boronates to Isochromene Acetals Catalyzed by Tartaric Acid.
Authors: Luan Yi , Barbato Keith S. , Moquist Philip N. , Kodama Tomohiro , Schaus Scott E.
Published: August 2015

A novel [4 + 2] cycloaddition to synthesize the title compounds bearing two chiral centers with high enantio‐ and diastereoselectivity is developed using the coupling reaction of isochromene acetals (I) with alkenyl boronates.
ChemInform Abstract: Enantioselective Cross‐Coupling of meso‐Epoxides with Aryl Halides.
Authors: Zhao Yang , Weix Daniel J.
Published: August 2015

The enantioselective reaction of a variety of cyclic epoxides with aryl bromides or cyclohexenyl triflate is studied in the presence of NiCl2 and a chiral menthyl substituted titanocene as catalysts.
ChemInform Abstract: Asymmetric Autocatalysis Triggered by Chiral Crystal of Achiral Ethylenediamine Sulfate.
Authors: Matsumoto Arimasa , Ide Takahiro , Kaimori Yoshiyasu , Fujiwara Satoshi , Soai Kenso
Published: August 2015

Achiral ethylenediamine forms chiral structures spontaneously when crystallized as the sulfate salt.
ChemInform Abstract: Synthesis of Trifluoromethyl‐Containing Polysubstituted Aromatic Compounds by Diels—Alder Reaction of Ethyl 3‐Benzamido‐2‐oxo‐6‐(trifluoromethyl)‐2H‐pyran‐5‐carboxylate.
Authors: Kondratov Ivan S. , Tolmachova Nataliya A. , Dolovanyuk Violetta G. , Gerus Igor I. , Daniliuc Constantin‐Gabriel , Haufe Guenter
Published: August 2015

The presence of the trifluoromethyl group is proposed to be the main factor in controlling the regioselectivity of the initial cycloaddition.
ChemInform Abstract: Hypoiodite‐Catalyzed Regioselective Oxidation of Alkenes: An Expeditious Access to Aldehydes in Aqueous Micellar Media.
Authors: Swamy Peraka , Reddy Marri Mahender , Naresh Mameda , Kumar Macharla Arun , Srujana Kodumuri , Durgaiah Chevella , Narender Nama
Published: August 2015

A highly anti‐Markovnikov‐selective oxidation of alkenes based on in situ generated hypoiodite catalysis in aqueous micellar media under mild conditions is described.
ChemInform Abstract: Palladium‐Catalyzed Aerobic Oxidative Dehydrogenation of Cyclohexenes to Substituted Arene Derivatives.
Authors: Iosub Andrei V. , Stahl Shannon S.
Published: August 2015

For the more challenging benzylic C—H bond activation such as in 2,3‐dihydrobenzofuran, a slightly modified catalyst system is required.
ChemInform Abstract: Facile Arene Hydrogenation under Flow Conditions Catalyzed by Rhodium or Ruthenium on Carbon.
Authors: Hattori Tomohiro , Ida Takashi , Tsubone Aya , Sawama Yoshinari , Monguchi Yasunari , Sajiki Hironao
Published: August 2015

The hydrogenation of aromatic rings including heteroarenes to saturated cyclic‐ring skeletons is completed under neutral conditions within 20 s during a single pass through a catalyst cartridge containing rhodium on carbon or ruthenium on carbon.
ChemInform Abstract: Bromination of Olefins with HBr and DMSO.
Authors: Karki Megha , Magolan Jakob
Published: August 2015

The reaction works well with terminal as well as internal olefins giving the respective dibromo adducts in good to excellent yields.
ChemInform Abstract: Metal‐Free Oxysulfenylation of Alkenes with 1‐(Arylthio)pyrrolidine‐2,5‐diones and Alcohols.
Authors: Yu Jipan , Gao Chang , Song Zhixuan , Yang Haijun , Fu Hua
Published: August 2015

A wide range of β‐alkoxy sulfides are conveniently and efficiently obtained from alkenes using readily available 1‐(arylthio)pyrrolidine‐2,5‐diones and alcohols as the oxysulfenylation reagents.
ChemInform Abstract: A Novel Transition Metal Free [Bis‐(trifluoroacetoxy)iodo]benzene (PIFA) Mediated Oxidative ipso Nitration of Organoboronic Acids.
Authors: Chatterjee Nachiketa , Bhatt Divya , Goswami Avijit
Published: August 2015

A convenient oxidative ipso nitration of various functionalized organoboronic acids under mild reaction condition using a combination of PIFA, NBS, and sodium nitrite as nitro source is presented.
ChemInform Abstract: Saccharin‐Based μ‐Oxo Imidoiodane: A Readily Available and Highly Reactive Reagent for Electrophilic Amination.
Authors: Yoshimura Akira , Koski Steven R. , Fuchs Jonathan M. , Saito Akio , Nemykin Victor N. , Zhdankin Viktor V.
Published: August 2015

Three new saccharin‐based hypervalent iodine compounds and a dinuclear analogue are prepared.
ChemInform Abstract: SNAr Reaction in Aqueous Medium in the Presence of Mixed Organic and Inorganic Bases
Authors: Shelke Nilesh B. , Ghorpade Ramrao , Pratap Ajay , Tak Vijay , Acharya B. N.
Published: August 2015

Efficient N‐arylation of fluorobenzonitriles is efficiently achieved in aqueous medium in the presence of a iPr2NEt/Na2CO3 base system.
ChemInform Abstract: A Formal anti‐Markovnikov Hydroamination of Allylic Alcohols via Tandem Oxidation/1,4‐Conjugate Addition/1,2‐Reduction Using a Ru Catalyst
Authors: Nakamura Yushi , Ohta Tetsuo , Oe Yohei
Published: August 2015

24 examples
ChemInform Abstract: A New Protocol for Nickel‐Catalyzed Regio‐ and Stereoselective Hydrocyanation of Allenes.
Authors: Arai Shigeru , Hori Hiroto , Amako Yuka , Nishida Atsushi
Published: August 2015

A simple method is elaborated for the regio‐ and stereoselective hydrocyanation of allenes (I) to trans‐alkenes (III).
ChemInform Abstract: Highly Selective Palladium—Benzothiazole Carbene‐Catalyzed Allylation of Active Methylene Compounds under Neutral Conditions.
Authors: Monopoli Antonio , Cotugno Pietro , Zambonin Carlo Giorgio , Ciminale Francesco , Nacci Angelo
Published: August 2015

The Pd‐benzothiazolylidene complex (NHC) is shown to be a highly chemoselective catalyst for the Tsuji—Trost allylation of active methylene compounds using carbonates as allylating agents.
ChemInform Abstract: Redox Tuning of a Direct Asymmetric Aldol Reaction.
Authors: Zhang Qiying , Cui Xiuling , Zhang Long , Luo Sanzhong , Wang Hui , Wu Yangjie
Published: August 2015

Using novel chiral ferrocenephane FCP as recyclable catalyst (at least 5 times), a number of cyclic ketones as well as acetone react with deactivated aldehydes to give corresponding aldol derivatives in modest to high yields with good to excellent dia‐ and enantioselectivities.
ChemInform Abstract: Catalytic Asymmetric Dearomatizing Redox Cross Coupling of Ketones with Aryl Hydrazines Giving 1,4‐Diketones.
Authors: Huang Shenlin , Koetzner Lisa , De Chandra Kanta , List Benjamin
Published: August 2015

1,4‐Diketones bearing an all‐carbon quarternary stereocenter are synthesized via asymmetric dearomatizing redox cross‐coupling reaction between aryl hydrazines and cyclic ketones in the presence of a SPINOL‐derived phosphoric acid as chiral catalyst.
ChemInform Abstract: Efficient Sonogashira and Suzuki—Miyaura Coupling Reaction Catalyzed by Pd‐Nanoparticles.
Authors: Balsane Kishor E. , Shendage Suresh S. , Nagarkar Jayashree M.
Published: August 2015

Pd nanoparticles, electrochemically deposited on Nafion‐graphene, show excellent catalytic activity in the title C—C cross‐coupling reactions.