bluuebunny/crossref_metadata_2025 huggingface dataset:
Fruits and vegetables intake improves birth outcomes of women with gestational diabetes mellitus and hypertensive disorders of pregnancy
Authors: Sewor Christian , Obeng Akua A. , Eliason Sebastian , Agbeno Evan K. , Amegah A. Kofi
Published: May 2022

Background
Disorders of pregnancy such as hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM) have been associated with adverse birth outcomes. However, to date, no study has explored the ameliorating role of maternal nutrition in the relationship between disorders of pregnancy and adverse birth outcomes. We investigated the relationship between HDP and GDM, and adverse birth outcomes in a Ghanaian population and evaluated the ameliorating role of fruit and vegetable consumption in the relationship.
Methods
We conducted a cross-sectional study among 799 mothers who had recently delivered singletons in the Cape Coast Metropolis, Ghana. Information on HDP and GDM, and birth outcomes were retrieved from the maternal health book of the mothers. A food frequency questionnaire was used to assess fruit and vegetable intake during pregnancy. Multivariable binary logistic regression was used to investigate the association between pregnancy disorders, and preterm birth (PTB) and low birth weight (LBW)
Results
These disorders of pregnancy were associated with increased odds of PTB (AOR = 6.53; 95% CI: 4.33, 9.83) and LBW (AOR = 8.41; 95% CI: 4.16, 17.01). In the stratified analysis, the odds of both PTB and LBW decreased with increasing fruits and vegetables consumption. The interaction p values were 0.0006 and 0.3985 for PTB and LBW, respectively.
Conclusions
We found mother’s experience of GDM and HDP to be associated with PTB and LBW in this Ghanaian population and further provide evidence of the ameliorating role of fruits and vegetables consumption in the observed relationship. Mothers diagnosed of GDM and HDP should be advised during their antenatal visits to increase intake of fruits and vegetable consumption to help safeguard their health and that of the developing foetus.
Efficacy and safety of circular incision endoscopic mucosal resection and endoscopic mucosal dissection in the treatment of rectal neuroendocrine tumors：A Meta analysis
Authors: Yu Shangping , Wang Yan , Tian Miao , Qian Hongmei
Published: May 2022

Background: circular endoincision endoscopic mucosal resection (EMR-C) and endoscopic mucosal daresection (ESD) is two common methods in the resection of the turine rectal neuroendocrine tumors. Because there is no clear consensus on the best endoscopic resection technology, we conducted a meta-analysis to compare the effectiveness and safety of ESD and EMR-C in the treatment of rectal neuroendocrine tumors. Methods: Pubmed, EMBASE, Cochrane Library and Web of science were screened until November 2021. In the pairwise meta-analysis, according to the tumor size, 7 kinds of literature were divided into tumor size < 10mm group and tumor size 10-16mm group for subgroup analysis, and the heterogeneity between each group was analyzed.random effect and fixed-effect models were used for analysis, and sensitivity analysis and bias tests were also carried out. Results: seven studies involving 340 cases of rectal neuroendocrine tumors. For tumors, less than 10mm, the overall resection and complete resection rate of ESD are equivalent to that of EMR-C. The incidence of intraoperative bleeding and postoperative complications are not significantly different, but ESD will take more operation time than EMR-C. For 10-16mm tumors, the overall resection and complete resection rate of ESD are significantly higher than that of EMR-C. The incidences of intraoperative bleeding were not significantly different, but ESD took more operation time than EMR-C. Conclusion: This study shows that ESD is more effective in the treatment of rectal neuroendocrine tumors larger than 10mm because ESD has a deeper and higher mucosal resection rate. For tumors of less than 10mm, the results of EMR-C were equivalent to those of ESD
Risk factors of pelvic fracture combined with humeral fracture: A retrospective study
Authors: Li Zhengjiang , Chen Xing , Zhang Yan , Li Shunqiang , Ji Haibo , Li Yongkui , Xing Shuxing
Published: May 2022

Background: Pelvic fractures are often associated with other injuries, and in our study, pelvic fractures associated with humeral fractures were the most common. We pooled patient data to analyze the independent risk factors for pelvic fractures associated with humeral fractures. Methods: A retrospective study was conducted on the clinical data of 254 patients with pelvic fractures admitted to the Department of Orthopedics of Chengdu Fifth People’s Hospital, from August 2017 to August 2021. Independent sample T test found that pelvic fractures combined with humeral fractures were statistically significant. The main outcome indicators of pelvic fracture combined with humeral fracture were as follows: Tile classification of pelvic fractures, number of humeral fractures and Injury Severity Scale (ISS); Secondary outcome indicators: gender, age, body mass index (BMI), cause of injury, underlying diseases, etc. Single factor analysis was performed to screen risk factors for each indicator, and logistic analysis was used to determine independent risk factors for indicators with P < 0.05. Results: Of the 254 patients with pelvic fractures, 24 (9.45%) were associated with humeral fractures, much higher than other single injuries, and only pelvic fractures associated with humeral fractures were statistically significant (P=0.014). Pelvic fractures without concomitant humeral fractures (n=230) and pelvic fractures with concomitant humeral fractures (n=24) were associated with age (P=0.006; 95% CI = 0.087-0.665; OR=10.258), ISS score (P=0.002; 95% CI = 1.839-4.445; OR=8.721), Tile scores (P=0.01; 95% CI = 22.554-87.419; OR=22.736), but there was no statistical significance in gender (P=1.03), BMI (P=0.437) and injury cause (P=3.04). Conclusion: The combination of pelvic fracture and humerus fracture was statistically significant, and age > 60 years old, pelvic fracture Tile B2 classification above and high ISS were the independent risk factors for humerus fracture in pelvic fracture. Therefore, in clinical work, when clinicians treat patients with pelvic fractures aged > 60 years old, Tile B2 type above classification of pelvic fractures and high ISS, they should be highly vigilant about whether the humerus fractures are accompanied.
Gut microbiota composition can reflect immune responses and identify latent tuberculosis infection in patients with poorly controlled diabetes: A prospective cohort study
Authors: Huang Hung-Ling , Luo Yong-Chun , Lu Po-Liang , Huang Cheng-Hsieh , Lin Kun-Der , Lee Meng-Rui , Cheng Meng-Hsuan , Yeh Yao-Tsung , Kao Cheng-Yuan , Wang Jann-Yuan , Yang Jinn-Moon , Chong Inn-Wen
Published: May 2022

Background
Diabetes mellitus (DM) is a major risk factor for tuberculosis (TB). Evidence has linked the DM-related dysbiosis of gut microbiota to modifiable host immunity to Mycobacterium tuberculosis infection. However, the crosslinks between gut microbiota composition and immunological effects on the development of latent TB infection (LTBI) in DM patients remain uncertain.
Methods
We prospectively obtained stool, blood, and medical records from 130 patients with poorly-controlled DM (pDM), defined as ever having an HbA1c > 9.0% within previous 1 year. Among them, 43 had LTBI, as determined by QuantiFERON-TB Gold in-Tube assay. The differences in the taxonomic diversity of gut microbiota between LTBI and non-LTBI groups were investigated using 16S ribosomal RNA sequencing, and a predictive algorithm was established using a random forest model. Serum cytokine levels were measured to determine their correlations with gut microbiota.
Results
Compared with non-LTBI group, the microbiota in LTBI group displayed a similar alpha-diversity but different beta-diversity, featuring decrease of Prevotella_9, Streptococcus, and Actinomyces and increase of Bacteroides, Alistipes, and Blautia at the genus level. The accuracy was 0.872 for the LTBI prediction model using the aforementioned 6 microbiome-based biomarkers. Compared with the non-LTBI group, the LTBI group had a significantly lower serum levels of IL-17F (p = 0.025) and TNF-α (p = 0.038), which were correlated with the abundance of the aforementioned 6 taxa.
Conclusions
The study results suggest that gut microbiome composition may modulate host immunity relevant to TB susceptibility, and microbial signature might be a potential diagnostic biomarker and therapeutic target for LTBI in pDM patients.
Wideband Mimo Antenna with Reduced Mutual Coupling
Authors: Srinivasa P.
Published: May 2022

This work presents a revolutionary compact wideband multiple-input-multiple-output (MIMO) antenna. On the basis of the S-parameters and the surface current distributions, the working mechanism of the dual-antenna is investigated. The measured − 10dB impedance bandwidth is 6.8 GHz, and the measured mutual coupling is less than 15 dB throughout the whole band, according to a prototype. It is possible to attain a clearance area of 30 mm x 20 mm. To ensure the diversity performance of the proposed MIMO antenna, MIMO parameters such as ECC, DG, CCL, and multiplexing efficiency are explored.
Association of income level and ischemic heart disease: potential role of walkability
Authors: Cerci Rodrigo Julio , Fernandes-Silva Miguel Morita , Vitola João Vicente , Cerci Juliano Julio , Neto Carlos Cunha Pereira , Masukawa Margaret , Gracia Ana Paula Weller , Silvello Lara Luiza , Prado Pedro , Guedes Murilo , Hino Adriano Akira Ferreira , Baena Cristina Pellegrino
Published: May 2022

Background: Socioeconomic status has been linked to ischemic heart disease (IHD). High-income neighborhoods may expose individuals to a walking-promoting built environment for daily activities (walkability). Data from the association between income and IHD is lacking in middle-income countries (MIC). It is also uncertain whether walkability mediates this association. Objectives: To investigate whether: income is associated with IHD in a MIC; and whether neighborhood walkability mediates the income-IHD association. Methods: This cross-sectional study evaluated 44,589 patients referred for myocardial perfusion imaging (SPECT-MPI). Income and walkability were derived from participants’ residential census tract. Walkability quantitative score combined four variables: street connectivity, residential density, commercial density, and mixed land use. IHD was defined by an abnormal myocardial perfusion during a SPECT-MPI study. We used adjusted mixed effects models to evaluate the association between income level and IHD; and performed a mediation analysis to measure the percentage of the income-IHD association mediated by walkability. Results: From 26,415 participants, those living in the lowest income tertile census tract were more physically inactive (79.1 vs 75.8 vs 72.7%) when compared to higher income census tracts (p<0.001). Income was associated with IHD (OR 0.90 [95%CI 0.87 – 0.94] for each US$ 1,000.00 increase in income). Census tracts with higher income were associated with better walkability (p <0.001), however, walkability did not mediate the income-IHD association (percent mediated = -0.3%).Conclusions: Income was independently associated with higher prevalence of IHD in a MIC. Although walkability was associated with census tract income, it did not mediate the income-IHD association.
Automated oxygen control for very preterm infants and neurodevelopmental outcome at two years – a retrospective cohort study
Authors: Salverda H.H. , Oldenburger N.J. , Rijken M. , Tan R.N.G.B. , Pas A.B. Te , Klink J.M.M. van
Published: May 2022

Faster resolution of hypoxaemic or hyperoxaemic events in preterm infants may reduce long-term neurodevelopmental impairment. Automatic titration of inspiratory oxygen increases time within the oxygen saturation target range and may provide a more prompt response to hypoxic and hyperoxic events. We assessed routinely performed follow-up at two years of age after implementation of automated oxygen control (AOC) as standard care and compared this with a historical cohort. Neurodevelopmental outcomes at two years of age were compared for infants born at 24–29 weeks gestational age before (2012–2015) and after (2015–2018) implementation of AOC as standard of care. Primary outcome was a composite outcome of either mortality or severe neurodevelopmental impairment (NDI), other outcomes assessed were mild-moderate NDI, Bayley-III composite scores, cerebral palsy GMFCS and CBCL problem behaviour scores. 289 infants were eligible in the pre-AOC epoch and 292 in the post-AOC epoch. Baseline characteristics were not significantly different. 51 infants were lost to follow-up (pre-AOC 6.9% (20/289), post-implementation 10.6% (31/292)). The composite outcome of mortality or severe NDI was observed in 17.9% pre-AOC (41/229) vs. 24.0% (47/196) post-AOC (p = 0.12). No significant differences were found for the secondary outcomes such as mild-moderate NDI, Bayley-III composite scores, cerebral palsy GMFCS and problem behaviour scores, with the exception of parent-reported readmissions until moment of follow-up which was less frequent post-AOC than pre-AOC. Conclusion In this cohort study, Implementation of automated oxygen control in our NICU as standard of care for preterm infants led to no statistically significant difference in neurodevelopmental outcome at two years of age.
Predictors of urinary function recovery after radical prostatectomy
Authors: Hakozaki Kyohei , Takeda Toshikazu , Yasumizu Yota , Tanaka Nobuyuki , Matsumoto Kazuhiro , Morita Shinya , Kosaka Takeo , Mizuno Ryuichi , Asanuma Hiroshi , Oya Mototsugu
Published: May 2022

Purpose: Even in the era of laparoscopic radical prostatectomy (LRP) and robot-assisted laparoscopic radical prostatectomy (RALP), we sometimes experience patients with severe urinary incontinence after surgery. The aim of this study was to identify the predictors of urinary continence recovery among patients with urinary incontinence immediately after surgery (UIIAS).Methods: We identified 274 patients with clinically localized prostate cancer who underwent LRP and RALP between 2011 and 2018. UIIAS was defined as a urine loss ratio > 0.15 on the first day of urethral catheter removal. Urinary continence recovery was defined as using ≤ 1 pad/day one year after surgery. In the present study, we evaluated the factors affecting urinary function recovery one year after surgery among patients with urinary incontinence immediately after LRP and RALP.Results: UIIAS was observed in 191 of 274 patients (69.7%). A multivariate analysis identified age (< 65 years, p = 0.015) as an independent predictor affecting immediate urinary continence. Among the 191 incontinent patients, 153 patients (80.1%) showed improved urinary continence one year after surgery. A multivariate analysis identified age (< 65 years, p = 0.003) and estimated blood loss (≥ 100 ml, p = 0.044) as independent predictors affecting urinary continence recovery one year after surgery. Conclusions: The present results suggest that younger patients and patients with higher intraoperative blood loss might recover urinary continence one year after surgery even if they are incontinent immediately after surgery.
Shortcuts to adiabatic population inversion via time-rescaling: stability and thermodynamic cost
Authors: Andrade Jair da Silva , França Angelo F. da Silva , Bernardo Bertúlio de Lima
Published: May 2022

A shortcut to adiabaticity (STA) is concerned with the fast and robust manipulation of the dynamics of a quantum system that reproduces the effect of an adiabatic process. A recently proposed method enables the generation of shortcuts from a prescribed slow dynamics by simply rescaling the time variable of the quantum evolution operator. This time-rescaling method does not demand knowledge about the eigenvalues and eigenstates of the Hamiltonian, and in many cases no additional coupling fields. Here, we use this approach to study the problem of speeding up the population inversion of a two-level quantum system. The fidelity of the dynamics versus systematic errors in the control parameters are shown to be comparable with other STA schemes. From a quantum thermodynamic viewpoint, we also demonstrate that the main properties of the distribution of work required to drivethe system along the shortcuts are unchanged with respect to the reference (slow) protocol.PACS numbers:
Performance Evaluation of Combining ICESat-2 and GEDI Laser Altimetry Missions for Inland Lake Level Retrievals
Authors: Zhang Zhijie , Chen Guodong , Bo Yanchen , Guo Xiaozu , Bao Jianteng
Published: May 2022

Monitoring lake water levels is important to fully understand the characteristics and mechanism of lakes’ dynamic change, the impact of climate change and human activities on lakes, etc. This paper first individually evaluated the performance of newly released Global Ecosystem Dynamics Investigation (GEDI) and the successor of Ice, Cloud, and Land Elevation Satellite mission (ICESat-2) for inland lake level retrieval over four typical lakes (Chaohu Lake, Hongze Lake, Gaoyou Lake and Taihu Lake) using in-situ gauge data, then lake levels of the two missions were combined to derive long time-series lake water levels. Compared with in-situ water levels, the validations revealed that very accurate results were obtained by ICESat-2 with R varing from 0.957 to 0.995, MAE 0.03 m-0.10 m and RMSE 0.04 m-0.13 m, however, larger bias occurred in GEDI results with R spanning from 0.560 to 0.952, MAE 0.31 m-0.38 m and RMSE 0.35 m-0.46 m. Before combination, the bias correction of GEDI was carried out. The annual change rate differences between the combined and the in-situ data were 0.06 m/yr, 0.05 m/yr, 0.05 m/yr and 0.02 m/yr for Lake Chaohu, Hongze, Gaoyou and Taihu, respectively. The monthly, seasonal and annual dynamics of inland lake water levels captured by combined GEDI and ICESat-2 missions agree well with measuremnts from hydrological stations. These encouraging results demonstrate the great potential for frequent and accurate lake level monitoring, which could be a valuable resource for the studies of hydrological and climatic change.
Bioinformatic analysis of COL10A1 expression correlates with poor prognosis and immune infiltration in pancreatic cancer
Authors: Liu Qi , Zhao Hongyu , Guo Yu , Zhang Kai , Shang Fengjia , Liu Tongjun
Published: May 2022

Background
Collagen type X alpha 1 (COL10A1) is a structural component of the extracellular matrix that is aberrantly expressed in a variety of cancer tissues. However, its role in pancreatic cancer progression is not well understood.
Methods
TCGA, GEO, and GEPIA data were employed to explore the expression of COL10A1 in normal and tumor tissues and its prognostic value in pancreatic adenocarcinoma. The clinical data of pancreatic cancer in TCGA were used to explore the relationship between COL10A1 and clinical features. Genes co-expressed with COL10A1 were explored using multiple databases and analyzed for functional enrichment. In addition, the lncRNA-miRNA-COL10A1 axis that may be involved in COL10A1 regulation in pancreatic cancer was explored by constructing a competitive endogenous RNA (ceRNA) regulatory axis. Finally, COL10A1 was analyzed for correlation with immune cell infiltration and various immune checkpoint molecules in pancreatic cancer to explore the mechanisms that may affect prognosis.
Results
It was found that the expression of COL10A1 was significantly increased in pancreatic cancer tissues. High expression of COL10A1 was related to the clinicopathological characteristics and the worse prognosis of pancreatic cancer patients. The role of COL10A1 in promoting pancreatic cancer progression may be mediated by the TUG1/miR-144-3p/COL10A1 axis. Besides, in pancreatic adenocarcinoma, the expression level of COL10A1 showed a significant positive correlation with tumor immune cell infiltration, biomarkers of immune cells, and expression of immune checkpoint molecules.
Conclusion
In this article, with the help of many bioinformatics techniques, we conclude that TUG1/miR-144-3p/COL10A1 axis is associated with immune infiltration of pancreatic cancer and leads to poor prognosis. COL10A1 is an early diagnostic marker and a potential therapeutic target for pancreatic cancer.
Mutational profiles of ovarian cancer in Chinese patients reveal potential therapeutic targets and prognostic markers
Authors: Lyu Tianjiao , Jiang Yahui , Ma Jinyan , Zhu Chongying , Shen Lifei , Sheng Yuhong , Liu Hua , Feng Weiwei
Published: May 2022

Background: Ovarian cancer (OC) is a common and lethal gynaecologic malignancy. The prognosis of OC is variable among different patients treated with standard of care therapies. Herein, we described the mutational profiles of OC to identify underlying therapeutic targets and prognostic markers.Methods: The study was performed on 38 Chinese patients with high-grade serous ovarian cancer (HGSOC). Most patients (86.8%) had advanced disease (stage III-IV). Tissue samples were subjected to capture-based targeted sequencing using a panel consisting of 520 cancer-related genes. Mutational profiles, including gene mutations and copy number variations (CNVs), were evaluated in each patient. Homologous recombination deficiency (HRD) status was also assessed. Analysis of the mutational profile with platinum-sensitivity, progression-free survival (PFS) and platinum-free interval (PFI) was performed.Results: Germline BRCA1 and BRCA2 mutations were identified in 5 (13%) and 2 (5%) patients, respectively. Somatic genetic alterations were mainly identified in TP53 (97%), BRCA1 (24%), RB1 (21%), FGF23 (21%), CCND2 (18%), RECQL4 (18%) and NF1 (16%). CNVs were comprehensively distributed in 242 genes, with 76% (29/38) of patients harbouring at least one CNV. In addition to BRCA1, somatic genetic alterations were also present in other homologous recombination repair (HRR) genes, including CDK12 (5%), BRCA2 (3%), ATM (3%), BRIP1 (3%), CHEK1 (3%) and FANCI (3%). In total, 22 of 38 (58%) patients had genetic alterations in the HRR pathway. The prognosis analysis indicated that BRCA1/2 mutations were significantly associated with improved PFI (p<0.05) and marginally associated with improved PFS (p=0.05). Patients with R0 resection found positive HRD showing a significant association with better PFI (p<0.05) and a marginal association with better PFS (p=0.06). In patients with NF1 mutation, improved PFS and PFI were observed. However, the difference was not ideal (PFS, p=0.06, PFI, p=0.084). Platinum-sensitivity was significantly associated with BRCA1/2 mutations (p<0.01). Conclusions: In OC patients, genetic mutations frequently occurred in both HRR and non-HRR genes. CNVs are widely present in many genes and patients. Mutational profiling also identified a number of potential therapeutic targets and prognostic markers at the molecular level that could contribute to the personalised treatment and management of OC.
Prevalence of depression and its correlation with anxiety, headache and sleep disorders amongst medical staff in South China
Authors: Lu Guangshuang , Xiao Shaobo , He Jiaji , Xie Wei , Ge Wei , Meng Fanchao , Yang Ying , Yu Shengyuan , Liu Ruozhuo
Published: May 2022

Background: Our previous studies reported the prevalence of primary headache and risk factors among medical staff in South China. The aim of this cross-sectional survey was to learn more about the prevalence of depression in medical staff and its risk factors, as well as to investigate the association between depression, anxiety, headache, and sleep disorders.Methods: Stratified random cluster sampling was used to select medical staff from various departments in four hospitals in Sanya City. Based on previously study, the Self-rating Depression Scale（SDS）, Self-rating Anxiety Scale (SAS), Pittsburgh Sleep Quality Index (PSQI) were used to quantitatively score the depression, anxiety and sleep disorders. Non-parametric Spearman correlation analysis and regression analysis were performed on the factors affecting the occurrence and severity of depression. Results: Among 645 medical staff, 548 (85%) responded. The 1-year prevalence of depression was 42.7% and the prevalence of depression combined with anxiety, headache and sleep disorders was 23%, 27% and 34.5%. The prevalence of depression in females, nurses, unmarried or single group, and rotating-shift population was significantly higher than that in males(48.3% vs 27.1%, OR=2.512), doctors(55.2% vs 26.7%, OR=3.388), married group(50.5% vs 35.8%, OR=1.900), and day-shift population(35.2% vs 7.5%, OR=1.719). The occurrence of depression was correlated with anxiety, sleep disorder, headache and migraine, with anxiety being the most significant (Spearman Rho = 0.531). The SDS was significantly correlated with SAS and PSQI (Spearman Rho = 0.801, 0.503), and also related to the presence of headache and migraine (Spearman Rho = 0.228, 0.159). Multivariate logistic regression indicated that nurse occupation and anxiety were risk factors for depression, while grades of anxiety, sleep disorders and nurse occupation were risk factors for depression degree in multiple linear regression.Conclusion: The prevalence of depression in medical staff is higher than that in the general population especially among females, nurse occupation, unmarried people and rotating-shift population. Depression is associated with anxiety, sleep disorders, headache and migraine. Anxiety and nurse occupation are risk factors for depression. This study might provide a reference for the promotion of occupational health among medical staff.
Gender differences in willingness for childbirth, fertility knowledge, and value of motherhood or fatherhood and their associations among college students in South Korea
Authors: KIM Hae Won , KIM Seo Yun
Published: May 2022

Background
South Korea is a country with a very low fertility rate and there is a tendency for young adults to postpone marriage and childbirth, which affects adverse pregnancy outcomes. It is important for young adults to predict and prepare in advance for future fertility-related issues, especially by identifying their willingness and thoughts about childbirth for both women and men. This study aimed to investigate gender differences in willingness for childbirth, fertility knowledge, and the value of motherhood or fatherhood among college students in South Korea and to explore the factors influencing willingness for childbirth.
Methods
This was a cross sectional study among 286 unmarried college students who were recruited through a campus email and online communities for college student conducted from June 20, 2021 to July 19, 2021. The data were analyzed using the chi-square test and t-test to identify gender differences in general characteristics, willingness for childbirth, fertility knowledge, and value of motherhood of fatherhood. The factors influencing willingness for childbirth were examined using multiple logistic regression.
Results
Female students showed lower willingness for future childbirth than male students (χ2 = 26.85, p < .001). Women valued motherhood significantly less than men valued fatherhood (t = 6.34, p < .001). Women had a lower fertility knowledge score than men (t = 2.53 p = .012). The value of motherhood or fatherhood was an important influencing factor in both male and female college students (AOR = 8.57, 95% CI = 3.79–19.41 and AOR = 10.42, 95% CI = 3.65–29.80, respectively), whereas the monthly allowance was also an important influencing factor in female students (AOR = 1.02, 95% CI = 1.01–1.03).
Conclusions
The findings indicate the future direction to develop effective interventions considering gender differences which will promote healthy pregnancy and childbirth in the future for informed reproductive decision-making for college students.
A Mathematical Model for the Quantification of Pulmonary and Intrapulmonary Arteriovenous Anastomoses Blood Flow
Authors: Vanni Rosalba
Published: May 2022

Objectives: To develop a model for the calculation of pulmonary blood flow (Q̇p) and blood flow through intrapulmonary arteriovenous anastomoses (Q̇IPAVA) under multiple physiological conditions.Methods: A mathematical model was developed into which many experimental physiological parameters were input. Data were obtained simultaneously from arterial blood gases, metabolic measures, and noninvasive measures of cardiac output (Q̇t) in young and healthy men.Results: It was possible to precisely calculate Q̇p and Q̇IPAVA at rest and at moderate (50% of VO2max) and heavy exercise (≥ 90% of VO2max) in both normoxia (FIO2 = 0.2093) and acute hypoxia (FIO2 = 0.125).In normoxia under heavy exercise, Q̇p decreased slightly (97.56% of Q̇t), and Q̇IPAVA represented 2.44% of Q̇t.Instead, in hypoxia at heavy exercise, Q̇p decreased significantly (85.25% of Q̇t), and Q̇IPAVA increased significantly (14.75% of Q̇t), equal to Q̇IPAVA of 3.48 L/min.It was possible to demonstrate a negative contribution of Q̇IPAVA directly to pulmonary gas exchange efficiency.Furthermore, the model immediately identifies incorrect Q̇t measurements.Conclusions: This new mathematical model is precise in calculating Q̇p and Q̇IPAVA.The required data are obtained through noninvasive instruments, which are easy to use and widespread in all hospitals. Q̇p differs significantly from Q̇t under some physiological conditions. The application of this model in the medical field is expected to enable further advancements in scientific research and clinical practice.
Clinical Expression, Prognosis and Immune Infiltration of SUV39H1 in Diffuse Large B-cell Lymphoma
Authors: Zhang Yue , Wen Qing , Lei Ya-Xin , Ge Jing-Jing , Kong Xiao-Shuang , Wang Wen-Hua , Wang Ze-Yuan , Hou Hu-Ting , Qian Si-Yu , Tang Canwei , Wu Shao-Xuan , Wang Guan-Nan , Li Wen-Cai , Zhang Ming-Zhi , Zhang Xu-Dong , Chen Qing-Jiang
Published: May 2022

Epigenetic regulation plays a crucial part in the oncogenesis and treatment of diffuse large B-cell lymphoma (DLBCL). The H3K9me3-specific histone methyltransferase SUV39H1 is a significantly epigenetic gene that promotes the progression of a variety of malignancies. However, the roles of SUV39H1 in DLBCL remain unclear. By retrieving Oncomine, GEPIA, CCLE, UALCAN, and TCGA databases, we observed that the expression of SUV39H1 was higher in DLBCL tissues than in normal and other cancer tissues. Combined with immunohistochemical validation assay, we analysed clinical characteristics of DLBCL patients. The results showed that high expression of SUV39H1 was closely associated with age over 50 years old (P=0.014) and low albumin level (P=0.015). In the prognostic analyses, DLBCL patients in GEPIA database showed that the high SUV39H1 expression group had a lower disease-free survival (DFS) rate than the low SUV39H1 expression group (P=0.035). Finally, we discovered that expressions of CD86+ and CD163+ macrophages have high correlations with SUV39H1+ in DLBCL tissues(with P=0.037 and P=0.045,respectively). SUV39H1-associated macrophages may downregulate T lymphocyte subsets, especially Treg cells in DLBCL(P=0.003). In summary, SUV39H1 might be not only a potential target for the epigenetic therapy and immunotherapy of DLBCL, but also a clinical indicator for doctors to evaluate the trend of disease development.
Scars from protected zero modes and beyond in $U(1)$ quantum link and quantum dimer models
Authors: Biswas Saptarshi , Banerjee Debasish , Sen Arnab
Published: May 2022

We demonstrate the presence of anomalous high-energy eigenstates, or
many-body scars, in U(1)U(1)
quantum link and quantum dimer models on square and rectangular
lattices. In particular, we consider the paradigmatic Rokhsar-Kivelson
Hamiltonian H=\mathcal{O}_{\mathrm{kin}} + \lambda \mathcal{O}_{\mathrm{pot}}H=𝒪kin+λ𝒪pot
where \mathcal{O}_{\mathrm{pot}}𝒪pot
(\mathcal{O}_{\mathrm{kin}}𝒪kin)
is defined as a sum of terms on elementary plaquettes that are diagonal
(off-diagonal) in the computational basis. Both these interacting models
possess an exponentially large number of mid-spectrum zero modes in
system size at \lambda=0λ=0
that are protected by an index theorem preventing any mixing with the
nonzero modes at this coupling. We classify different types of scars for
|\lambda| \lesssim \mathcal{O}(1)|λ|≲𝒪(1)
both at zero and finite winding number sectors complementing and
significantly generalizing our previous work [Banerjee and Sen, Phys.
Rev. Lett. 126, 220601 (2021)]. The scars at finite
\lambdaλ
show a rich variety with those that are composed solely from the zero
modes of \mathcal{O}_{\mathrm{kin}}𝒪kin,
those that contain an admixture of both the zero and the nonzero modes
of \mathcal{O}_{\mathrm{kin}}𝒪kin,
and finally those composed solely from the nonzero modes of
\mathcal{O}_{\mathrm{kin}}𝒪kin.
These scars have tell-tale energies such as (non-zero) integers and
irrationals like \pm \sqrt{2}±2
at \lambda=0λ=0
or n_1 \lambda \pm n_2n1λ±n2
at \lambda \neq 0λ≠0
where both n_1, n_2n1,n2
are integers. We give analytic expressions for certain ``lego scars’’
for the quantum dimer model on rectangular lattices where one of the
linear dimensions can be made arbitrarily large, with the building
blocks (legos) being composed of emergent singlets and other more
complicated entangled structures.
Study on Physical and Mechanical Properties of Porous Concrete using Recycled Concrete Aggregate
Authors: Mukesh T.S.
Published: May 2022

Abstract. While porous concrete has a poor compressive strength because of its porous structure, concrete will lead to failure when the load applied is high. With recycled concrete aggregate and PVA fibre, an attempt was made to improve porous concrete's physical and mechanical properties. The features of ingredients such as recycled concrete aggregate, cement, Polyvinyl alcohol fibre, and water were first discovered, and then the mix was created and cast. After proper curing, the mechanical properties of concrete were determined by conducting the following tests: compression strength, split tensile strength, and flexural strength, along with physical factors such as permeability. The findings reveal that using the aggregate size of 1012mm improves mechanical characteristics. Permeability was also excellent. On the other hand, strength increased as the percentage of PVA fibre grew and at a certain point strength as well as porosity decreased. The maximum strength was attained at an incorporation % of 1. The mechanical characteristics of the aggregate declined when the size increased, as the surface area available for the cement to bind them together shrank.
Moment Resisting Steel Connections for the Improvement of Light Gauge Cold Formed Steel Structures
Authors: Ashwathi R.
Published: May 2022

Abstract. Steel has much importance over other construction materials in recent days because of its high strength and ductility. It has high resistance to tension when compared to concrete in compression. This paper mainly focuses to evaluate the beam column rolled and cooled formed steel connection by moment resistant connection with the help of stiffened, unstiffened and splices connections. Due to its economical development and best seismic performance by various shapes in cross sectional area and different connections it has been widely used. By clubbing these criteria, it results to study the seismic performance of cold formed steel sections area using different moment resistance connection. At long last the report result the graft association has best second opposition association, seismic safe of designs, load conveying limit is high what's more, least weight contrast and different sorts of associations. The join association load conveying limit is high, so we can diminish the size of segment and forestall the base shear because of decreasing the heaviness of the designs.
Laboratory Studies on the Effectiveness of Quarry Dust and Bottom Ash with Treated Marine Clay for Adaptable Flexible Pavement Sub-Grade
Authors: Veeranki S.T.
Published: May 2022

Abstract. The soil found on the sea bed is classed as Marine clay. The major proportion of marine soil is clay so it is generally referred as marine clay (MC). The MC is often weak and lacks stability in heavy loads. This research is concerned with the potential of BA (Bottom ash) and QD (Quarry dust) as soil stabilizers based on resistance enhancement. Soil stabilization points to make strides the geotechnical features of the MC. The engineering properties of MC have been built-up, such as grain size distribution, particle density and soil plasticity. The soil sample was blended and compacted with various quantities of the BA and QD i.e. 2.5%, 5%, 7.5%, 10% 12.5% and 15% for compaction and strength test. The dry-weight method was utilized to prepare the samples. A standard Proctor test was run to determine the stabilized floor OMC and MDD. In the interim, the CBR was conducted to obtain the strength of the stabilized soil. Test results indicate that the MDD of the MC has been improved by 0.19 (g/cc) on addition of 10% BA and it has been improved by 0.246 (g/cc) when 10% QD is added when compared with untreated MC. Laboratory analyses of the cyclic plate load test revealed the ultimate load carrying capacity of the treated MC model flexible pavement has been increased by 349.9% at OMC when compared with untreated MC model flexible pavement.
Management of asymptomatic hyperuricemia in chronic kidney disease: A proposed stepwise approach
Authors: Gawad Mohammed Abdel , Zaki Dina , Qasem Anass
Published: May 2022

Serum uric acid levels are frequently elevated in patients with chronic kidney disease (CKD). The relatively modest hyperuricaemia in CKD may reflect the reduced efficiency of renal excretion of urate. In the past two decades, basic research has shown that hyperuricaemia plays a causal role in the progression of CKD through direct renal injury. However, clinical studies have reported conflicting results, hence there is much controversy about the scope of treating asymptomatic hyperuricaemia to prevent or reduce the rate of CKD progression. In this review, we highlight the most recent guidelines and clinical trials that tested the use of urate-lowering therapy in the management of asymptomatic hyperuricaemia in CKD patients. Keywords: uric acid, hyperuricaemia, chronic kidney disease
Implementation of direct current to direct current converter exploiting power amplifier
Authors:   Faculté des Sciences et de Technologies, Université des Montagnes, Bangangté, Cameroon, Hamadou Aissatou
Published: May 2022

In the last years, RF power amplifiers are taking advantage of the switched dc-dc converters to use them in several architectures that may improve the efficiency of the amplifier, keeping good linearity. In this study a DC-DC power converter design suitable for high-frequency applications by using a class E power amplifier (Inverter), instead of using small battery values choosing Radio Frequency (RF) values and getting high efficiency of output voltage and a maximum of current and voltage values between 0-9 mW of power input in rectifier, the class E power amplifier designed by using GaN HEMT device and the power added efficiency of 64% after getting optimization of matching network and the gain is 14.4 dBm.
A Large Eddy Simulation Study of Cyclones: The Effects of Interparticle Collisions on Erosion Prediction
Authors:   Centro Federal de Educação Tecnológica de Minas Gerais, Av. Ministro Olavo Drummond, 25 Araxá, Brazil - ZIP: 38.180.510, Martins Diego Alves de Moro , Andrade João Rodrigo ,   Department of Mechanical Engineering, Federal University of Uberlândia, Fluid Mechanics Laboratory, Campus Santa Mônica, Uberlândia, Minas Gerais, Brazil - ZIP: 38400-902, Duarte Carlos Antonio Ribeiro ,   Faculty of Engineering, Federal University of Catalão, Av. Dr. Lamartine Pinto de Avelar, 1120, Catalão, Goiás, Brazil, Salvo Ricardo de Vasconcelos ,   Federal University of Technology - Paraná, Campus Londrina. Av. dos Pioneiros, 3131 Londrina - Parana, Brazil - ZIP: 86036-370, Souza Francisco José de ,   Department of Mechanical Engineering, Federal University of Uberlândia, Fluid Mechanics Laboratory, Campus Santa Mônica, Uberlândia, Minas Gerais, Brazil - ZIP: 38400-902
Published: May 2022

Cyclone separators are widely used in fluid catalytic cracking (FCC) units due to their lack of moving parts and relatively low-pressure drop. However, cyclone separators are prone to erosion-related issues, which is a major drawback. In this paper, a large eddy simulation (LES) of the particle-gas flow in a cyclone separator is investigated using a four-way Euler-Lagrange approach to model inter-particle collisions and the exchange of momentum between particles and fluid. The effects of inter-particle and particle-wall collisions are characterized in terms of erosive wear. Additional effects involving the exchange of momentum between the fluid and the particles are also discussed. The results show that considering the interparticle collisions between solid particles may be the key to predicting erosion.
Integrating Mindfulness Practice in Cognitive Behavioral Hypnotic Psychotherapy
Authors:   Bnai-Zion Medical Center, Haifa, Israel, Yezreel Valley College, Israel, Arnon Zahi
Published: May 2022

After the emergence of Mindfulness in the Western world, many studies proved its mental and physical benefits. However, implementing Mindfulness in psychotherapy has several challenges: therapists are not formal Mindfulness instructors; the Mindfulness course is a continuous eight-week course, which many patients do not attend during therapy, while others attend and drop out. Thus, Hypnosis was applied to shorten and strengthen the desired changes. The article describes the logic behind this integration, demonstrates it using a case study, and details the ideas, philosophy, and hypnotic scripts in the appendix.
The Effect of Dissemination Pathways on Uptake and Relative Costs for a Transdiagnostic, Self-guided Internet Intervention for Reducing Depression, Anxiety, and Suicidal Ideation: Comparative Implementation Study
Authors: Batterham Philip J , Gulliver Amelia , Kurz Ella , Farrer Louise M , Vis Christiaan , Schuurmans Josien , Calear Alison L
Published: May 2022

Background

Self-guided web-based programs are effective; however, inadequate implementation of these programs limits their potential to provide effective and low-cost treatment for common mental health problems at scale. There is a lack of research examining optimal methods for the dissemination of web-based programs in the community.

Objective

This study aimed to compare the uptake, reach, relative costs, and adherence associated with 3 community-based pathways for delivering a low-intensity web-based transdiagnostic mental health program. The 3 dissemination pathways were social media advertising, advertising in general practice, and advertising in pharmacies.

Methods

Participants were recruited on the web, from general practices, or from community pharmacies; completed a screener for psychological distress; and were offered the 4-week FitMindKit program—a 12-module psychotherapeutic intervention. Uptake was defined as the number of participants who enrolled in the web-based program; reach was defined as the rate of uptake per exposure; and costs were calculated based on staff time, equipment, and advertising. Adherence was assessed as the number of modules of FitMindKit completed by the participants.

Results

Uptake comprised 1014 participants who were recruited through the 3 dissemination pathways: on the web (991/1014, 97.73%), in general practice (16/1014, 1.58%), and in pharmacy (7/1014, 0.69%). Reach was highest for social media: 1 in every 50 people exposed to web-based advertising took up the intervention compared with 1 in every 441 in general practitioner clinics and 1 in every 1708 in pharmacies. The dissemination cost was US $4.87 per user on social media, US $557 per user for general practitioner clinics, and US $1272 per user for pharmacy dissemination. No significant differences in adherence were observed between the conditions, whereas all pathways showed an underrepresentation of men and linguistic diversity.

Conclusions

The web-based dissemination pathway was the most efficient and cost-effective for delivering a self-guided internet-based mental health program to people in the community. More research is needed to identify how best to engage men and those with culturally diverse backgrounds in web-based interventions.

Trial Registration

Australian New Zealand Clinical Trials Registry ACTRN12618001688279; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=376113
The effects of an individualized smartphone-based exercise program on self-defined motor tasks in Parkinson’s disease: A pilot study (Preprint)
Authors: Gaßner Heiko , Friedrich Jana , Masuch Alisa , Jukic Jelena , Stallforth Sabine , Regensburger Martin , Marxreiter Franz , Winkler Jürgen , Klucken Jochen
Published: May 2022

BACKGROUND

Bradykinesia and rigidity are prototypical motor impairments of Parkinson’s disease highly influencing everyday life. Exercise training is an effective treatment alternative for motor symptoms, complementing dopaminergic medication. High frequency training is necessary to yield clinically relevant improvements. Exercise programs need to be tailored to individual symptoms and integrated in patients’ everyday life. Due to the COVID-19 pandemic, exercise groups in outpatient setting were largely reduced. Developing remotely supervised solutions is therefore of significant importance.

OBJECTIVE

Aim of this pilot study was to evaluate a digital, home-based, high frequency exercise program for PD patients.

METHODS

15 patients with PD received four weeks of personalized exercise at home using a smartphone-app, remotely supervised by specialized therapists. Exercises were chosen based on the patient-defined motor impairment. Intervention effects were evaluated using the Unified Parkinson Disease Rating Scale, part III (UPDRS-III), standardized sensor-based gait analysis, Timed Up and Go Test (TUG), 2-Minute-Walk-Test, quality of life (PDQ-39), and patient-defined motor tasks of daily living. Usability of the smartphone-app was assessed by System-Usability-Scale (SUS).

RESULTS

Motor symptoms rated by UPDRS-III improved by 14 %, mobility-related QoL by 14 %, and QoL regarding social support by 19 %, however each without reaching significance level. Patient-defined motor tasks of daily living significantly improved in 13 out of 15 patients by 40 % on average. Changes of sensor-based gait parameters or functional gait tests were not observed. The SUS reached an average score of 72.2 ± 6.5 indicating good usability of the smartphone-app.

CONCLUSIONS

This pilot study presented that a tailored, digital, home-based, and high frequency exercise program over four weeks improved patient-defined motor activities of daily life based on a self-developed patient-defined impairment score indicating that digital exercise concepts may have the potential to beneficially impact motor symptoms of daily living. Future studies should investigate sustainability effects in controlled study designs conducted over a longer period of time.