bluuebunny/crossref_metadata_2025 huggingface dataset:
Treatment of Knee Medial Osteoarthrosis Using Open Corrective Osteotomy of the Tibia
Authors: Prizov A. P , Kopylov A. A , Epstein A. A , Lazko F. L , Kubashev A. A , Belyak E. A , Zagorodniy N. V , Kulikova O. I
Published: October 2020

Treatment results using high open corrective tibial osteotomy with tricalcium phosphate block (OTIS 50) and fixation by angle-stable mini plate (OTIS C PLUS) are presented for a 47 years old female patient with 3rd stage gonarthrosis. Evaluation of functional condition was performed by Joseph and Kaufman scale that made up 72 and 95 points before and 3 years after surgery, respectively. Control knee arthroscopy and histologic examination results showed partial restoration offibrous hyaline cartilage in the injured knee compartment.
Modern View on Pathogenesis of Non Traumatic Osteonecrosis
Authors: Panin M. A , Zagorodniy N. V , Karchebnyi N. N , Sadkov I. A , Petrosyan A. S , Zakirova A. R
Published: October 2020

Non traumatic osteonecrosis of the femoral head is one of the leading causes of hip function loss in young patients. At the late stages of this disease the only way to restore motor activity is total hip arthroplasty. Literature review presents the systematic analysis of the most significant causes of this disease (long-term intake of corticosteroids, alcohol abuse, thrombophilia). Pathogenetic mechanisms of femoral head vascularization disturbance are considered. In recent decades the fundamental genetic studies enabled to establish that pathogenesis of femoral head osteonecrosis is based on the polymorphisms of genes that ensure coagulation cascade, and angiogenesis disturbance.
Algorithm of treatment results HIV-infected patients with extra articular long bone fractures
Authors: Doronin N. G. , Khoroshkov S. N. , Maksimov S. L. , Yarigin N. V.
Published: October 2020

Algorithm of treatment results HIV-infected patients with extra articular long bone fractures
Rib deformity correction in children with pectus excavatum
Authors: Kolesov Sergey V. , Khaspekov Dmitriy V. , Snetkov Alexander A. , Sar Artur S. , Kazmin Arkadiy I.
Published: October 2020

The article is devoted to a comparative analysis of the surgical treatment of pectus excavatum. A prospective, single-center, non-randomized study of the immediate results of the correction of pectus excavatum in children and adolescents is presented.

Material and methods. The treatment results of 40 patients (27 men and 13 women) aged 3 to 18 years, operated between March 2005 and March 2016 were analyzed. All patients were examined according to the standard algorithm: chest MSCT, spirometry. All patients were divided into 2 groups. Group I patients operated on by the open resection method with plastic surgery of the costal arches (n=27). Group II patients operated with the use of minimally invasive technology according to NUSS, which does not provide for correction of deformation of costal arches (n=13).

Results. In group II, significantly less blood loss was noted (35.7 ml versus 137 ml in group I, p0.05), shorter duration of surgery (230 min versus 27.5 min in group I, p0.05). It is worth noting the earlier discharge from the hospital in patients with minimally invasive correction of deformity.

Conclusion. Minimally invasive thoracoplasty is an effective way to correct pectus excavatum in children and adolescents, which can significantly reduce the duration of surgery and intraoperative blood loss, is comparable in basic terms with reconstructive surgery, but inferior due to the lack of correction of deformation of the rib arches.
The value of the MTHFR polymorphisms in pathogenesis of nontraumatic necrosis of femoral head
Authors: Panin Mikhail A. , Zagorodnii Nikolai V. , Samokhodskaya Larisa M. , Boiko Andrei V.
Published: October 2020

Introduction. Among the etiological factors of non-traumatic avascular necrosis of the femoral head are the following: the prolonged use of corticosteroids, alcohol abuse, systemic lupus erythematosus, sickle cell anemia, the Legg Calve Perthes disease, ionizing radiation, cytotoxic agents, etc. At the same time necrosis of the femoral head might occur in the absence of the above factors (idiopathic necrosis). The reasons for idiopathic avascular necrosis could be a mechanical obstacle to the flow of blood, thrombotic occlusion of vessels, extravascular compression.

The purpose of this study is to examine the role of C677T gene mutation of the MTHFR gene in the development of non-traumatic avascular necrosis of the femoral head.

Materials and methods. During this study there was a comparative analysis of the frequency of the C677T gene allelic variants conducted in 41 patients with a verified diagnosis of non-traumatic avascular necrosis (main group) and 320 healthy individuals (control group). The survey program included the study of polymorphisms of MTHFR C677T gene by PCR.

Results. Differences in the frequency of occurrence of C allele of C677T gene MTHFR in the heterozygous state in case of non-traumatic avascular necrosis and in its absence were not statistically significant (51.2% against 37.2% respectively, 2 = 3.014, p = 0.083). The genotype TT (T in the homozygous state) of the C677T MTHFR gene was detected in 19.5% of the main group patients. A similar index in the control group was two times lower and amounted to 9.0 percent, the differences between groups statistically significant, 2 = 4.314, p = 0.038.

Conclusion. The study showed the importance of having the T C677T MTHFR gene in the pathogenesis of non-traumatic avascular necrosis of the femoral head. The data obtained and the analysis of the current literature suggests that this polymorphism is one of genetic predictors of non-traumatic avascular necrosis of the femoral head and other cardiovascular diseases as well.
Empirical Investigations of the Instrument Response for Distributed Acoustic Sensing (DAS) across 17 Octaves
Authors: Paitz Patrick , Edme Pascal , Gräff Dominik , Walter Fabian , Doetsch Joseph , Chalari Athena , Schmelzbach Cédric , Fichtner Andreas
Published: October 2020

With the potential of high temporal and spatial sampling and the capability of utilizing existing fiber-optic infrastructure, distributed acoustic sensing (DAS) is in the process of revolutionizing geophysical ground-motion measurements, especially in remote and urban areas, where conventional seismic networks may be difficult to deploy. Yet, for DAS to become an established method, we must ensure that accurate amplitude and phase information can be obtained. Furthermore, as DAS is spreading into many different application domains, we need to understand the extent to which the instrument response depends on the local environmental properties. Based on recent DAS response research, we present a general workflow to empirically quantify the quality of DAS measurements based on the transfer function between true ground motion and observed DAS waveforms. With a variety of DAS data and reference measurements, we adapt existing instrument-response workflows typically in the frequency band from 0.01 to 10 Hz to different experiments, with signal frequencies ranging from 1/3000 to 60 Hz. These experiments include earthquake recordings in an underground rock laboratory, hydraulic injection experiments in granite, active seismics in agricultural soil, and icequake recordings in snow on a glacier. The results show that the average standard deviations of both amplitude and phase responses within the analyzed frequency ranges are in the order of 4 dB and 0.167π radians, respectively, among all experiments. Possible explanations for variations in the instrument responses include the violation of the assumption of constant phase velocities within the workflow due to dispersion and incorrect ground-motion observations from reference measurements. The results encourage further integration of DAS-based strain measurements into methods that exploit complete waveforms and not merely travel times, such as full-waveform inversion. Ultimately, our developments are intended to provide a quantitative assessment of site- and frequency-dependent DAS data that may help establish best practices for upcoming DAS surveys.
DynTriPy: A Python Package for Detecting Dynamic Earthquake Triggering Signals
Authors: Yun Naidan , Yang Hongfeng , Zhou Shiyong
Published: October 2020

Long-term and large-scale observations of dynamic earthquake triggering are urgently needed to understand the mechanism of earthquake interaction and assess seismic hazards. We developed a robust Python package termed DynTriPy to automatically detect dynamic triggering signals by distinguishing anomalous seismicity after the arrival of remote earthquakes. This package is an efficient implementation of the high-frequency power integral ratio algorithm, which is suitable for processing big data independent of earthquake catalogs or subjective judgments and can suppress the influence of noise and variations in the background seismicity. Finally, a confidence level of dynamic triggering (0–1) is statistically yielded. DynTriPy is designed to process data from multiple stations in parallel, taking advantage of rapidly expanding seismic arrays to monitor triggering on a global scale. Various data formats are supported, such as Seismic Analysis Code, mini Standard for Exchange of Earthquake Data (miniSEED), and SEED. To tune parameters more conveniently, we build a function to generate a database that stores power integrals in different time and frequency segments. All calculation functions possess a high-level parallel architecture, thoroughly capitalizing on available computational resources. We output and store the results of each function for continuous operation in the event of an unexpected interruption. The deployment of DynTriPy to data centers for real-time monitoring and investigating the sudden activation of any signal within a certain frequency scope has broad application prospects.
Decentering Durham
Authors: Mithlo Nancy Marie
Published: October 2020

This section of the AICRJ special issue on fraud looks back to a 2017 group conversation (first published in First American Art Magazine no. 19 (Fall 2017): 84–89) as four Native American scholars and artists respond to the then-traveling retrospective exhibit Jimmie Durham: At the Center of the World in light of Durham’s long-standing claims to Cherokee identity. In “Decentering Durham,” Chiricahua Apache scholar Nancy Marie Mithlo argues that, “Cultural institutions continue to accept his platform, and, in doing so … deny Indigenous cultural sovereignty to name our own members and leaders.” Roy Boney Jr., a Cherokee artist, discusses Durham’s appropriation of the writings of historic statesman Zeke Proctor in “Not Jimmie Durham’s Cherokee.” In a “Walk-through at the Hammer,” Luiseño-Diegueño performance and installation artist James Luna (1950–2018) muses on the aesthetics of Durham’s work and the value of community belonging. Summarizing the 2017 perspective in “A Chapter Closed?,” artist and editor America Meredith (Cherokee Nation) hopes that, “after a multigenerational, multi-tribal effort … art historians and curators will cease … positioning [Durham] as our representative in academic literature.”
Claims to Native Identity in Children’s Literature
Authors: Reese Debbie
Published: October 2020

This commentary essay examines several individuals who wrote books for children and made claims to Native identity that are fraudulent, or otherwise problematic. Asa Carter, for example, posed as a Cherokee named “Forrest Carter” and published The Education of Little Tree, put forth as the autobiography of someone who had been on the Trail of Tears. So popular that it was published in Korean, Turkish, Czeck, Slovenian, and Spanish, in 1997 Little Tree became a feature film. Although the author’s fraud was exposed in The New York Times, the book continues to be published. Jamake Highwater, posing as a Blackfoot/Cherokee, won the most prestigious children’s literature award, the Newbery Honor given by the American Library Association, for Anpao: An American Indian Odyssey, in 1978. Paul Goble is a British writer who loved American Indian stories so much that he moved to the United States to live near Plains tribes, where he was given a Native name. Both that name and the ways he spoke of the gift led people to believe that he had been adopted into the Lakota tribe. Like Carter and Highwater, but more prolific, Goble’s books sell well in a market that retains narrow and stereotypical views of Native peoples. The essay concludes by discussing the ways that the works of Carter, Highwater, and Goble impact publishing today.
El Tratado Jardín de Nobles Doncellas y su influencia en la personalidad de Isabel la Católica
Authors: Regalado del Valle Vanesa
Published: October 2020

En la tratadística de la segunda mitad del siglo XV, en los reinos de Castilla y de León, observamos una corriente muy interesante, la de tratados y escritos dirigidos a la formación de los jóvenes, especialmente a los infantes e infantas destinados a ocupar un lugar en monarquías propias o ajenas. Así, en este contexto, surge la obra central de este artículo, el tratado educacional Jardín de nobles doncellas de fray Martín Alonso de Córdoba (Martín de Córdoba), y dirigido a la que se convertiría en la Reina Isabel I (Isabel La Católica tras 1496). Como veremos a lo largo de estas líneas, este tratado no solo poseía una vertiente formativa, sus lecciones iban más allá del mero aprendizaje. ¿Podríamos decir que este tratado influyó en la forma de actuar y gobernar de la futura Reina Isabel? Poco a poco lo iremos descubriendo en este estudio.
Las Ordenanzas Picariles, de Mateo Alemán
Authors: Rodríguez López-Vázquez Alfredo
Published: October 2020

En 1601 aparece publicado en Valencia y sin nombre de autor un texto doble: por un lado un largo poema de 340 versos, La vida de los pícaros, atribuido a Liñán de Riaza y a Bartolomé de Argensola en otras versiones, y acompañando a este texto que coincide con un capítulo de la primera parte del Guzmán de Alfarache. En la edición de Valencia se dice que ambos textos son del mismo autor, lo que refuerza la propuesta global de atribución a Mateo Alemán.
Juan Negrín López: De la victoria a la resistencia
Authors: Pérez Cobo Javier
Published: October 2020

El presente artículo tratará la figura de Juan Negrín López como presidente del gobierno republicano junto con su estrategia de resistencia ante las derrotas del ejército republicano. La capacitación de este personaje junto con su proyección internacional serán aspectos importantes para desarrollar estas políticas de resistencia.
Critical role of microglia in the inflammatory response after spinal injury
Authors: Shi Ya-Yun
Published: October 2020

Spinal cord injury induces a robust neuroinflammatory response that includes marked changes in the variety of endogenous CNS cell types specially microglia. In response to spinal injury, microglia undergo dramatic changes in cell morphology and promote inflammatory responses, which result in production of inflammatory factors and oxidative stress including reactive oxygen species. Further pro-inflammatory cytokines and chemokines are also rapidly up-regulated and likely contribute to microglial activation. This topic review will explore the current research on microglial responses to spinal injury and the recent progress in the pharmacologic and molecular targeting of microglia in spinal injury. Finally, we explore the argument for a positive versus negative role of microglia after spinal cord injury.
New drug and clinical trial rules, 2019: an overview
Authors: Annapurna Swathi A. , Rao Srinivasa Y.
Published: October 2020

Clinical trials are indispensable to the drug development method to confirm the effectiveness and safety of any new drug. India has undergone a big restrictive transformation about clinical trials. Numerous establishments taking part in a distinguished role in guiding the trial in India embody DCGI, DBT, ICMR, CBN, RCGM and GEAC. The government notified the new drugs and trial rules on 19 March 2019, to supersede part XA and schedule Y of the drugs and cosmetics rules 1945. Updating our knowledge about these is of utmost importance in today’s turbulent scenario that prevails in the pharmaceutical industry. Thus, this review gives an idea about the recent changes regarding the regulations of clinical trials.
Wilkie's syndrome in an adolescent female patient
Authors: A. Ali Bandar Idrees , Bukhari Khuloud Omar , Alzahrani Abdullah Saeed
Published: October 2020

One of the rare cases of the upper gastrointestinal tract obstruction is superior mesenteric artery syndrome (SMAS) but potentially life-threatening if not recognized early. It is due to loss of fat pad between the aorta and SMA which will lead to a compression of the third portion of the duodenum. It has a different angle which will lead to different presentations as well as severity. We are reporting the 15 year-old (y/o) female who is medically free, presented to the emergency department (ED) complaining of severe colicky epigastric abdominal pain for the last 5 days in the epigastric area. The diagnosis of SMAS was made after clinical and radiological investigation. After proper supportive resuscitative measures, definitive management of the surgery was done by laparoscopic approach (duodenojejunostomy). The diagnosis of SMA syndrome is considered challenging due to many presentations and might be confused with other clinical conditions. Unless early diagnosed and treated, the outcome might be catastrophic. Medical treatment is attempted first in many cases depending on the severity and presentation but if failed, surgery will be the best option.
Surgical management of the patient with factor V deficiency: a case report
Authors: Ozmus Duygu C. , Ozmus Dogay N. , Akpak Yasam K. , Onur Zeynep Y. , Canday Mujde , Yurtkal Aslihan
Published: October 2020

Factor V (FV) is a rare bleeding disorder that its incidence is one in a million. Patients with FV deficiency have typically mucosal bleeding and prolonged bleeding after an invasive procedure. There are no certain treatment modalities and there is no product of FV concentrates in the markets. The bleeding diathesis and protect the ovarian viability are a challenge as an opposite situation for treatment options and ovarian preservation after detorsion is controversial. We aimed to provide ovarian blood-stream, control bleeding and protect thromboembolism from the patient with all of our treatment in the light of literature and a few case reports.   
Positioning of Wireless Sensor Network under Emergency Communication Environment
Authors: Yuan Ruilin
Published: October 2020

With the development of microelectromechanical system (MEMS), embedded system, and wireless communication, it is now feasible to implement and deploy wireless sensor network (WSN) in emergency communication environment. However, the positioning accuracy of WSN nodes needs to be further improved. To solve the problem, this paper improves the initial value calculation method of multi-hop positioning algorithms, which are suitable for emergency communication environment, and puts forward a WSN node positioning algorithm that narrows the initial values of Kalman filter. By narrowing the initial value range of Kalman filter, the specially deployed sensors could accurately derive its position from the known positions of anchor nodes. To prevent error accumulation in the network, distributed computing was performed to solve the global nonlinear optimization problem, and calculate the position of the nodes. Simulation results show that the proposed algorithm can improve the WSN positioning accuracy under emergency communication environment, while greatly saving computing and communication costs. The research further improves the practicability and efficiency of multi-hop positioning algorithms in emergency communication environment.
Research on Construction Technology and Quality Control of Electromechanical Installation Engineering for Buildings
Authors: Zhang Wending
Published: October 2020

Mechanical and electrical installation is a very important construction technology in construction engineering. From the perspective of the construction unit, whether the installation technology and procedure are scientific and reasonable will have a direct impact on the final quality of the project, and it is also closely related to the personal and property safety of the residents. Based on this, construction organizers should construct and perfect a standardized installation construction quality management system, clarify management regulations, and control key technical points, so as to comprehensively improve the quality of electromechanical installation projects and improve the project qualification rate. This article will describe the construction technology and quality control strategy of electromechanical installation engineering, aiming to lay a theoretical foundation for the improvement of engineering qualification rate and construction quality.
Kilka uwag o przyszłości Europy w świetle prognoz demograficznych
Authors: Okólski Marek
Published: October 2020

Artykuł został oparty głównie na wynikach prognozy ludności świata opublikowanej przez ONZ w 2019 r. Dowodzą one, że w okresie do 2060 r. zaludnienie Europy zmniejszy się o 60 mln osób. Jest to zjawisko długotrwałe: między 1950 a 2100 r. nastąpi spadek udziału Europy w populacji całego globu z 22% do 6%. Główną jego przyczynę stanowi niski poziom dzietności, który nie zapewnia odtwarzania kolejnych generacji w niezmniejszających się rozmiarach. Inną ważną konsekwencją trwającej długo bardzo niskiej dzietności jest demograficzne starzenie się populacji, przejawiające się w odwróceniu proporcji liczebnych między grupą dzieci i młodzieży a grupą ludzi w starszym wieku na rzecz tej drugiej oraz silny spadek relacji liczbowej między grupą osób w wieku produkcyjnym a grupą osób w wieku poprodukcyjnym.

Depopulacja oraz silne zestarzenie się ludności stawia Europę w najmniej korzystniej sytuacji demograficznej wśród wszystkich kontynentów. Największy kontrast występuje w porównaniu z Afryką, której ludność będzie nadal silnie wzrastać, osiągając w 2100 r. 34% populacji świata (11% w 1950 r.), oraz gdzie zostanie zachowana przewaga liczebna dzieci i młodzieży nad osobami w wieku starszym.

Zmiany demograficzne w Europie będą istotnie zróżnicowane regionalnie. Względnie korzystna sytuacja wystąpi w Europie Zachodniej, na której obszarze liczba ludności nieznacznie się zwiększy (głównie dzięki imigracji), a dynamika starzenia się będzie umiarkowana, niekorzystna zaś w Europie Południowej i Europie Wschodniej, gdzie pojawi się silna depopulacja i silne tempo starzenia się.

Zdaniem autora prognozy ludnościowe w niedostatecznym stopniu uwzględniają potencjał migracyjny obszarów pozaeuropejskich, zwłaszcza Afryki, wynikający z gwałtownego przyrostu osób należących do młodych grup tzw. wieku produkcyjnego. Można bowiem oczekiwać, że znaczna część tego potencjału podejmie próby emigracji, skierowanej przede wszystkim w stronę Europy. To zaś spowoduje zapewne istotny wzrost udziału ludności muzułmańskiej w populacji większości krajów europejskich, wystawiając na trudną próbę stosunki międzykulturowe w tych krajach.
Integracja i relacje międzykulturowe wczoraj i dzisiaj — filozofia migracji
Authors: Rebes Marcin
Published: October 2020

W niniejszym artykule poruszony został problem integracji w kulturze europejskiej. Proces integracyjny stanowi ważny element każdej kultury. W kulturze europejskiej pojawił się on na samym początku, gdy kultura ta powstawała, i trwa przez cały czas jej rozwoju, choć przybiera różne formy w zależności od sytuacji społeczno-politycznej. Współczesna integracja nawiązuje do XVIII-wiecznego kształtowania się państw narodowych i konfrontacji z uniwersalnymi wartościami. Stosunek do innych kultur i tożsamość europejska odsyłają do takich wartości, jak wspólne dobro, wolność czy odpowiedzialność. Jak pokazuje filozofia XX-wieku, ważnym elementem stała się relacja między ja i innym, drugim. Wartości kształtują się między nami. Przez ten pryzmat możemy dostrzec problem migracji, której podstawą jest walka o prawa człowieka. Wokół tej walki powstaje tożsamość europejska. Relacje międzyludzkie ukazują znaczenie i sens migracji, która inspiruje Europę do pogłębionej integracji.
Living with Time
Authors: Kweon Leigh (Mean Seo)
Published: October 2020

This article researches time in the early childhood education classroom. This inquiry troubles the dominance of chronological, linear time that prescribes and predicts daily routines in a goal-oriented manner in pursuit of future development. Through this project I hope to offer alternative perspectives on time beyond modernist and neoliberal abstraction and refocus on how the learning experience can be shaped by attending to the presentness of childhoods.
Effect of Dentin Pretreatment with Chlorhexidine on Push-Out Bond Strength of Composite Restorations in Severely Damaged Primary Anterior Teeth
Authors: Milani Shabnam , Seraj Bahman , Khoshlafz Zahra , Abazarian Niusha
Published: October 2020

Objectives: Achieving durable restorations with adequate strength in severely damaged primary anterior teeth in children is a priority. The aim of this study was to investigate the effect of dentin pretreatment with chlorhexidine on push-out bond strength of composite restorations.
Materials and Methods: In this in vitro experimental study, 56 extracted primary anterior teeth were randomly divided into 4 groups: (1) saline and total-etch bonding agent, (2) chlorhexidine and total-etch bonding agent, (3) saline and self-etch bonding agent, and (4) chlorhexidine and self-etch bonding agent. After the application of bonding agents, the post space was filled with Z250 composite resin. Following thermocycling of the samples, the push-out test was performed using a universal testing machine, and the results were analyzed with two-way ANOVA.
Results: The mean push-out bond strength values in groups 1 to 4 were 5.7, 8.39, 5.35, and 7 MPa, respectively. Chlorhexidine groups had significant differences with saline groups in bond strength (P<0.05) but there was no statistically significant difference between the self-etch and total-etch bonding agents in the groups (P>0.05).
Conclusion: Both types of bonding agents (self-etch and total-etch) exhibited favorable results in radicular dentin of primary anterior teeth; however, pre-treatment with chlorhexidine increased the push-out bond strength of composite restorations in primary anterior teeth.
Evaluation of FOXP1 gene expression in pediatric B-cell precursor acute lymphoblastic leukemia patients at remission induction therapy
Authors: Tamaddon Gholamhossein , Bahraini Mehran , Fazeli Alieh
Published: October 2020

Background: Transcription factors (TFs) play a key role in the development, therapy, and relapse of B-cell malignancies, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Given the essential function of Forkhead box protein P1 (FOXP1) transcription factor in the early development of B-cells, this study was designed to evaluate FOXP1 gene expression levels in pediatric BCP-ALL patients and NALM6 cell-line.
Materials and Methods: This case-control study was done on the NALM6 cell-line and bone marrow specimens of 23 pediatric BCP-ALL patients (median age: 7.5 years; range: 2.0 – 15.0 years) at different clinical stages including new diagnosis, 15th day after the treatment, and relapse. Also, 10 healthy children were included as the control group. FOXP1 gene expression was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR). The correlation analysis was performed between the FOXP1 gene expression and patients’ demographic and laboratory characteristics.
Results: The results showed that FOXP1 gene expression was significantly downregulated in the NALM-6 cell-line (median=0.05, P<0.001) and patients at new diagnosis (median=0.06, p<0.0001), and relapse (median=0.001, p<0.0001) phases, compared to the control group (median=0.08). FOXP1 gene expression on the 15th day of the treatment was significantly higher than its level at the new diagnosis stage (p<0.001). Moreover, FOXP1 gene was significantly downregulated in the relapse phase compared to the new diagnosis. Patients whose number of bone marrow blasts on the 15th day of the treatment was below 5% had higher FOXP1 gene expression at the diagnosis phase (Spearman’s correlation, P<0.05, r=-0.485) and higher ratio of diagnosis/day 15 (p<0.001, Mann-Whitney U test).
Conclusions: FOXP1 levels could be a potential biomarker of therapy response in remission induction therapy for pediatric BCP-ALL patients.
DNA methylation of tumor suppressor genes in hepatocellular carcinoma
Authors: Sanaei Masumeh , Kavoosi Fraidoon , Modaresi Farzan
Published: October 2020

The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of methylation localized in normally unmethylated CPG islands mediate chromatin compaction resulting in gene silencing and cancer induction. The current review article aimed to assess and analyze the available literature on the tumor suppressor genes (TSGs) hypermethylation in hepatocellular carcinoma (HCC). For this review article, the suitable studies were obtained by searching PubMed, SCOPUS, NCBI, and Ovid database from 1995 up to September 2018 with the MeSH terms combined with free terms.  A total 1483 Items were identified in SCOPUS (n = 459), PubMed (n = 832), Ovid (n = 118), and other reference sources (n = 74). After the assessment, 73 manuscripts were included in the current study. In total, 13 genes were found to have the most effect on HCC. Therefore, we selected them to evaluate as candidate genes in this cancer. TSGs can affect cell cycle during various stages of the cycle an at the cell cycle checkpoints. The hypermethylation of these genes results in chromatin compaction and TSGs silencing which induces HCC.
Caracterização do material precursor de placas de baterias chumbo ácido com aditivo de carbono em forma de grafite
Authors: Carvalho Santana Lucas , Marinato Lucas Bonella , Silva Luiz Felipe Neiva da , Carvalho Cynthia Mayara de , Brito Gilberto Augusto de Oliveira
Published: October 2020

A bateria chumbo-ácido é um dos acumuladores de energia mais comumente utilizados atualmente. Com isso, a implementação de aditivos para melhor performance nessas baterias vem ocorrendo nos últimos anos, impulsionando estudos nessa área. No presente trabalho, objetivou-se entender como as diferentes concentrações de aditivos de carbono na forma de grafite nas placas de baterias chumbo-ácido influenciam sua estrutura morfológica e cristalina. Para isso, miniplacas, sem e com aditivo, foram confeccionadas e analisadas pelas técnicas de Microscopia Eletrônica de Varredura (MEV) e Difração de Raios-X (DRX). Conclui-se que a morfologia muda drasticamente nas concentrações de 1 e 2% de aditivo em relação à morfologia do material sem aditivo, o que não foi observado para as concentrações de 0,5 e 0,75%. Não foram encontradas diferenças nas fases cristalinas entre as amostras.
Construção de uma câmara de cura piloto com alimentação a vapor para produção de placas de baterias de chumbo-ácido
Authors: Dalvi Beatriz Gueler , Santos Kaike Costa , Carvalho Santana Lucas , Carvalho Cynthia Mayara de , Brito Gilberto Augusto de Oliveira
Published: October 2020

Na produção de baterias chumbo-ácido, a etapa principal é o processo de cura de placas empastadas. Embora haja estudos tratando do processo de cura, principalmente com os objetivos de otimizar a etapa e melhorar o desempenho das baterias, existe a necessidade de um estudo sistematizado deste processo. Deste modo o principal objetivo deste trabalho é a construção de um equipamento em escala piloto com controle de umidade e temperatura, mais comumente conhecido no setor como câmara de cura. Com isso, tem-se o intuito de operá-la em diferentes condições a partir das variações de umidade e temperatura, que influencia diretamente nas propriedades do material precursor obtido após a etapa de cura. O piloto construído apresentou resultados satisfatórios, sendo, portanto, de grande valia para o estudo da influência da umidade e temperatura com as características do material precursor.
Toward Crowd-sourced Soundscape Monitoring in Protected Areas: Integrating Sound Dominance and Triggers to Facilitate Proactive Management
Authors: Gale Trace , Ednie Andrea
Published: October 2020

This research expanded on prior use of visitor perception data to inform potential social indicators of soundscape quality, by integrating existing urban-context soundscapes work, and the emerging use of triggers to help managers identify concerns before they reach the threshold level. Along with existing measures of sound appeal and acceptability, sound dominance helped provide a sense of how the extent of particular sounds influenced visitor experiences and a desire to visit more. Geospatial data collection for 899 visitors and eight sites within the Coyhaique National Reserve (CNR) in southern Chile during the summer high visitation season of 2019, allowed researchers to examine perceptual similarities and differences, facilitating an evaluation of new perceptual variables for soundscape monitoring. Correlation analyses identified informative relationships between the dominance (sound duration and foreground/background placement) of natural and anthropogenic sounds, and overall soundscape ratings. The duration of natural sounds was positively correlated with soundscape-level ratings, while the duration of anthropogenic sounds was negatively correlated with these ratings. Unique trends and relationships were identified across specific sites, demonstrating the value of adding measures of perceived sound dominance to soundscape monitoring processes. Observed Protected Area (PA) visitor enthusiasm for sounds and soundscapes suggests potential for crowd-sourced citizen science-based methods that could be done voluntarily and regularly using simple and accessible applications and technologies.
MÁS DATOS HISTÓRICOS EN LAS INSCRIPCIONES DE PALENQUE
Authors: Ruz Lhuillier Alberto
Published: October 2020

Hasta hace algo más de diez años, los estudiosos de la cultura maya, a1 referirnos al contenido de las inscripciones jeroglíficas, nos limitábamos a repetir lo que nos habían enseñado nuestros maestros, Spinden, Morley, Thompson, principalmente, a saber, que ninguna información histórica revelaban tales inscripciones.
Algunos aspectos del venado en la religión de los mayas de Yucatán
Authors: Montolíu María
Published: October 2020

El venado en la cultura maya, tanto antigua como contemporánea, ha desempeñado un papel importante, sobre todo en ciertos aspectos de la religión. El presente trabajo es un breve estudio de las diferentes funciones de dicho animal relativas a la cacería y al sacrificio rituales; a su relación con los dioses del panteón maya y a su papel como símbolo de la fertilidad. Este trabajo se refiere particularmente a los mayas de Yucatán, prehispánicos y contemporáneos; pero añadiremos datos de otros pueblos mayas con la finalidad de hacer comparaciones y completar los materiales que presentaremos.
Bibliografía de Alberto Ruz Lhuillier
Authors: V. de León Orozco Javier
Published: October 2020

La presente bibliografía esta basada principalmente, en el Currículo Vitae original del Dr. Alberto Ruz L., y en las referencias bibliográficas que el mismo hace en algunas de sus publicaciones. También se consultaron las bibliotecas del Museo Nacional de Antropología, Instituto de Investigaciones Antropológicas, y "Alberto Ruz Lhuillier" del Centro de Estudios Mayas, las dos Ultimas de la Universidad Nacional Autónoma de México, encontrándose en ellas algunas de sus conferencias mecanografiadas, las cuales también están citadas.
Punta Laguna: un sitio prehispánico de Quintana Roo
Authors: Benavides Castillo Antonio , Zapata Rene Lorelei
Published: October 2020

A principios de 1984 el Instituto de Investigaciones Antropológicas de la UNAM y el Centro Regional del Sureste del INAH efectuaron la segunda temporada de un proyecto conjunto de excavación de unidades habitacionales en Coba, Quintana Roo. Ese año la temporada de lluvias fue especialmente abundante, de manera que el nivel del lago Coba subió 1.50 m (fenómeno similar al ocurrido en 1969 segt1n informantes locales) e inundó sectores entre los que se encontraban los de las casetas de custodies y de venta de boletos para entrar a la zona arqueológica. En vista de tal situación y aprovechando los recursos económicos restantes del proyecto (por parte del INAH) durante noviembre y diciembre se construyeron nuevas instalaciones de acceso al sitio. Otras partidas fueron destinadas al mantenimiento anual del campamento del INAH y a la zona arqueológica (chapeos, reapertura de brechas y techumbres de materiales perecederos para estelas y tableros). Finalmente, una pequeña parte del presupuesto se aplicó a la prospección de los a1rededores de Coba, centrándonos en el sitio de Punta Laguna.
SUSTAINABLE DEVELOPMENT OF SOCIETY: PROBLEMS AND PROSPECTS
Authors:   FSBEI HE ", Titova Lyudmila G. ,   Yaroslavl state university named after P. G. Demidov"
Published: October 2020

The article examines the problems of sustainable development of modern societies, identifies their causes and the evolution of views on the origins of unstable and non-equilibrium development in the spatial and temporal aspect of social and political processes. Identify the factors of territorial sustainability, stresses the importance of humanization of development of all spheres of society, the role of education in formation of personality, able to independently decide within fragile and conflict in the world. The fact of General global instability of development is emphasized. Achieving the sustainability of social systems is currently a debatable and difficult task, the main problem of its solution is the inability to meet the growing needs of both individuals and society as a whole due to the exhaustion of resources on a global scale. Of course, production and distribution in some countries is ahead of time, in others it leads to a lag at the level of previous centuries. The uneven evolution of different countries in the direction of technological structure and artificial replenishment of their own resource base, the desire of countries that have entered the era of technological take-off to take priority political and military positions, gives rise to many planetary and territorial conflicts. The technological progress itself is contradictory, all the consequences of which are still unclear, poorly understood by people, and therefore are often perceived as a threat to man himself and the future of mankind. The new era has shown that at the current level, political management and police-military pressure cannot cope with numerous social, economic, environmental, ethnic, and religious problems, and their resolution must be at a deeper intellectual and cultural level. It is obvious that the importance of forming a person who is able to understand the risks of modern civilization is increasing, breaking through the muddy waves of information flows, misinformation and myths, and the role of education and upbringing is growing many times. Step-by-step solution of these tasks can begin with separate territories that localize and concentrate the rules, methods and methods of concretizing the combined actions of administrations, citizens, parties, social movements, and cultural and educational institutions.
A Perspective About the Construction of the “Hospital de Campanha Porto.”
Authors: Araújo António , Vaz Filipa Machado , Duarte Manuela , Rocha Carla , Rosendo Eugénia
Published: October 2020

N/a.
Peran Akses E-Jurnal Internasional untuk Para Mahasiswa Selama masa Work from Home
Authors: Nugroho Prasetyo Adi
Published: October 2020

Pandemi Covid-19 benar benar mengubah tatanan hidup sebagian besar masyarakat di Indonesia. Selama masa  PSBB, semua instansi pendidikan baik sekolah, balai diklat, tempat kursus, maupun universitas meliburkan kegiatan belajar mengajar yang selama ini dilaksanakan dengan tatap muka dikelas. Akses  E-jurnal bisa menjadi salah satu solusi untuk mengatasi kendala keterbatasan akses literatur pada pendidikan tinggi. studi ini bertujuan untuk menjelaskan akses –jurnal bagi para akademisi. Studi ini menggunakan metode kaulitatif. Data dikumpulkan dengan studi kepustakaan. Temuan data selanjutnya dianalisis dengan pendekatan analisis deskriptif. Hasil studi menunjukkan bahwa Akses  E-jurnal tidak hanya didapat dari berlangganan jurnal, tapi juga dari artikel buatan akademisi yang telah dipublikasikan oleh jurnal tujuan. Selain itu, open access memberikan kemudahan bagi para akademisi dalam menambah literatur yang mereka butuhkan, sehingga bisa melewati situasi work from home dengan tetap produktif.
Librarians and Post Truth World: Peluang dan Strategi Perpustakaan di Tengah Crisis of Critical Thinking
Authors: Cahyani Indah Rachma
Published: October 2020

Kemudahan akses informasi membuat masyarakat dengan mudah memproduksi informasi, post truth era membuat kita leluasa untuk memproduksi, menggunakan, menyimpan informasi, sekalipun informasi tersebut adalah sebuah kebohongan dan jauh dari kata benar, baik itu informasi yang bersifat daily life hingga informasi yang disajikan untuk akademisi. Artikel ilmiah ini menggunakan menggunakan metode analisis kajian pustaka, dengan mengumpulkan berbagai artikel ilmiah, penelitian yang berkaitan dengan tema kajian yang akan dibahas. Penulis memiliki tujuan untuk menggambarkan lebih jauh strategi pustakawan dalam tantangan menghadapi meluasnya kualitas informasi di era Post truth, selain itu penulis juga ingin menggambarkan tantangan serta peluang bagi pustakawan di era post truth. Artikel ilmiah ini mengungkapkan bahwa keberadaan perpustakaan dan pustakawan dipost truth era masih dan lebih dibutuhkan. Pustakawan mampu menjadi “penjernih” di dalam “keruhnya” informasi, kesalahan dalam informasi akan memengaruhi seseorang dalam pengambilan keputusan. Pustakawan dan perpustakaan akan terus digunakan sebagai jembatan informasi yang mampu memberikan alternatif-alternatif dalam pemilihan informasi yang tepat dan akurat.
Implementasi Therapeutic Landscape dalam Perpustakaan
Authors: Puspitasari Dewi
Published: October 2020

Perpustakaan merupakan tempat pembelajaran sepanjang hayat bagi setiap insan. Untuk dapat menjadi tempat belajar nyaman dan menyenangakan, perpustakaan dapat mengadopsi konsep theraupetic landscape. Theraupetic landscape dapat diartikan sebagai tempat, taman, gedung atau lokasi yang dapat memberikan penyembuhan secara mental dan fisik serta spiritual, sehingga orang-orang tersebut merasa lebih baik. Artikel ini menggunakan studi pustaka mengenai konsep theraupetic landscape. Implementasi theraupetic landscape di perpustakaan dapat dijabarkan secara luas yaitu Perpustakaan sebagai tempat penyembuhan yang holistik memiliki beberapa tujuan yaitu Perpustakaan tempat untuk mendapatkan Ilmu Pengetahuan, Perpustakaan tempat untuk mendapatkan berbagai macam informasi, Perpustakaan sebagai tempat untuk meredakan ketegangan belajar, perpustakaan sebagai tempat berkumpul komunitas, perpustakaan sebagai tempat aktuliasasi diri. Theraupetic landscape ini memungkinkan perpustakaan banyak melakukan kolaborasi, melahirkan inovasi dan kreatifitas baru. Tujuan dari theraupetic landscape pemustaka merasa lebih baik setelah datang ke perpustakaan.
EVENTOS QUATERNÁRIOS DE ENTULHAMENTO E CONFIGURAÇÃO DE FUNDOS DE VALE NA BACIA DO RIO PARAOPEBA – CRÁTON DO SÃO FRANCISCO, SUDESTE DO BRASIL
Authors: Carvalho Alex de , Magalhães Junior Antonio Pereira , Oliveira Letícia Augusta Faria de
Published: October 2020

Neste artigo, buscou-se reconstituir os eventos quaternários de entulhamento sedimentar e a consequente configuração morfogenética de fundos de vales na bacia do rio Paraopeba, Cráton do São Francisco, Minas Gerais. Foram investigados os processos morfogenéticos e o contexto geomorfológico relacionados à formação, arranjo espacial e evolução dos espessos depósitos de sedimentos fluviais presentes nos fundos dos vales fluviais de afluentes do Médio e Baixo rio Paraopeba, MG. Na maior parte dos vales analisados, foram encontrados até três níveis deposicionais fluviais: a planície de inundação, um terraço preservado e um nível deposicional alterado pelo coluvionamento (N1, N2 e N3, respectivamente). A partir da análise do arranjo espacial dos níveis deposicionais, da granulometria e da organização das fácies dos depósitos fluviais, propõe-se que ocorreram na região ao menos quatro eventos sedimentares regionais (ESR1, ESR2, ESR3 e ESR4), que podem ser associados ao controle litoestrutural e tectônico. O ESR1 corresponde ao evento mais antigo e é representado pelos depósitos de N3. Esses depósitos apresentam indícios de condições de deposição com maior energia. Os eventos ESR2 e ESR3 são representados pelos N2 dos médios cursos e dos N2 dos baixos cursos dos afluentes da margem direita, respectivamente. O ESR4 está associado à formação dos N1 nos baixos cursos dos vales investigados. Os eventos de sedimentação locais estão associados à formação dos N2 e N1 nos altos cursos dos ribeirões do Ouro e das Lajes e dos N1 nos médios cursos de todos os afluentes, que podem corresponder a eventos deposicionais cronologicamente diferentes. Considerando os níveis deposicionais escalonados, a organização da drenagem e os resultados da análise morfométrica, é possível inferir que o condicionamento tectônico foi responsável por soerguimentos e/ou basculamentos na região. O rico quadro estrutural foi herdado dos ciclos Transamazônico e Brasiliano. Ele é composto por falhas e zonas de cisalhamento que foram reativadas ao longo do tempo geológico e podem favorecer o controle tectônico regional. Por outro lado, o controle litológico tem papel importante na organização dos depósitos fluviais. Os diques básicos e os veios de quartzo exercem são responsáveis pelo estabelecimento de níveis de base locais em alguns trechos dos cursos fluviais e favorecem a preservação de depósitos de N2 em níveis altimétricos distintos. Os dados da datação por LOE sugerem que o ESR2 ocorreu entre 17.600 ± 2.780 e 15.800 ± 2.500 anos AP, o evento de sedimentação dos N2 nos trechos de Alto curso dos ribeirões do Ouro e das Lajes ocorreu 6.250 ± 1.100 e 2.850 ± 420 anos AP e o ESR3 ocorreu entre 2.750 ± 420 e 1.250 ± 190 anos AP.