bluuebunny/crossref_metadata_2025 huggingface dataset:
Energy-Efficient Geopolymer Composites Containing Phase-Change Materials—Comparison of Different Contents and Types
Authors: Przybek Agnieszka , Łach Michał , Bogucki Rafał , Ciemnicka Justyna , Prałat Karol , Koper Artur , Korniejenko Kinga , Masłoń Adam
Published: September 2024

The purpose of this study was to analyze the effects of phase-change components on the properties of geopolymer foams. Geopolymer foams are lightweight foamed geopolymers that are characterized by a high degree of porosity. Phase change materials, on the other hand, are compounds that, when added to a material, allow it to absorb, store, and then release large amounts of energy. Three types of PCMs, i.e., MikroCaps, GR42, and PX25, were introduced at 15% by weight. Geopolymer materials were produced based on silica fly ash, and hydrogen peroxide H2O2 was used to foam the geopolymer structure. The PCM geopolymer composites were cured at 60 °C. The produced materials were tested for physical, chemical, and thermal properties. The tests included oxide and mineral composition analysis of the base material, PCM particle size analysis, apparent density and porosity tests on the foams, water leachability tests, thermal tests (λ, Cv, Cp, α), and structural and textural analysis. The most relevant tests to confirm the performance of the phase-change materials were thermal tests. With the introduction of PCMs, volumetric heat capacity increased by as much as 41% and specific heat by 45%, and thermal diffusivity decreased by 23%. The results confirm the great potential of geopolymer composites as modern insulation materials for buildings and structures.
A Review of Non-Powder-Bed Metal Additive Manufacturing: Techniques and Challenges
Authors: Xu Jie , Fei Yifan , Zhu Yuanzhe , Yu Wei , Yao Donggang , Zhou Jack G.
Published: September 2024

Metal additive manufacturing has significantly evolved since the 1990s, achieving a market valuation of USD 6.36 billion in 2022, with an anticipated compound annual growth rate of 24.2% from 2023 to 2030. While powder-bed-based methods like powder bed fusion and binder jetting dominate the market due to their high accuracy and resolution, they face challenges such as lengthy build times, excessive costs, and safety concerns. Non-powder-bed-based techniques, including direct energy deposition, material extrusion, and sheet lamination, offer advantages such as larger build sizes and lower energy consumption but also encounter issues like residual stress and poor surface finish. The existing reviews of non-powder-bed-based metal additive manufacturing are restricted to one technical branch or one specific material. This survey investigates and analyzes each non-powder-bed-based technique in terms of its manufacturing method, materials, product quality, and summary for easy understanding and comparison. Innovative designs and research status are included.
Welding Characteristics of Medium Titanium Plates with Autogenous Laser Welding and Narrow-Gap Laser Filling Welding Modes
Authors: Li Junzhao , Yu Hang , Yin Xin , Kong Bin , Wen Kai , Sun Qingjie , Wang Bingfeng , Zeng Xianshan
Published: September 2024

Titanium and titanium alloys with a medium thickness of 5 to 12 mm are widely used for ocean platforms, military equipment and in other fields because of their light weight, appropriate strength and corrosion resistance. In this study, autogenous laser welding and narrow-gap laser welding processes were researched and compared, and the welding characteristics, weld microstructure and joint strength were analyzed. The results showed that autogenous laser welding had higher efficiency, narrower weld width and higher microstructure uniformity. Autogenous laser welding can achieve the single pass weld penetration at laser keyhole mode. The weld width of narrow-gap laser welded joint was 12.5 mm, which was nearly three times than that of autogenous laser welding. The grain size of autogenous laser welding was obviously smaller and more uniform in depth than that of narrow-gap laser welding. In the weld zone, the coarse columnar α grains grew from the fusion line, while in the heat-affected zone, equiaxed α grains with needle and sawtooth α morphologies were presented. The microhardness of the heat-affected zone was higher than in the weld zone and the base metal due to the denser needle microstructure. The tensile samples all fractured at the base metal, indicating the welded joint strength efficiency was greater than 1.
Optimization and Experimental Study of Iron Ore Grinding Medium Parameters Using EDEM Discrete Element Software
Authors: Yin Zhifeng , Zhang Yuhang , Zhu Huajun , Ding Hao , Wu Qisheng , Zhu Zheyu , Song Jiming
Published: September 2024

Energy savings and consumption reduction of ball mills are crucial for industrial production. The grinding medium is an important component of a ball mill. In theory, using higher-density grinding media can yield better grinding results. However, for materials with varying grindability, employing grinding media of different densities can reduce energy consumption while maintaining the same grinding effect. This study simulates the motion of the grinding media in the mill using three different densities of balls and the same material (iron ore). The results reveal that balls with densities of 5.8 g/cm3 and 7.8 g/cm3 achieve faster grinding of materials into finer particles, but balls with a density of 5.8 g/cm3 consume less energy. Therefore, replacing a ball with a density of 5.8 g/cm3 in a ball mill can significantly reduce energy consumption. This study will assist in selecting the optimal grinding medium density for different materials, ultimately contributing to energy savings and reduced carbon emissions.
Enhanced Epoxy Composites Reinforced by 3D-Aligned Aluminum Borate Nanowhiskers
Authors: Song Hyunseung , Song Kiho , Hwang Haejin , Ahn Changui
Published: September 2024

Recently, the durability of high-performance and multifunctional portable electronic devices such as smartphones and tablets, has become an important issue. Electronic device housing, which protects internal components from external stimuli, such as vibration, shock, and electrical hazards, is essential for resolving durability issues. Therefore, the materials used for electronic device housing must possess good mechanical and electrical insulating properties. Herein, we propose a novel high-strength polymer nanocomposite based on 3D-aligned aluminum borate nanowhisker (ABOw) structures. ABOw was synthesized using a facile hydrothermal method, and 3D-aligned ABOw structures were fabricated using a freeze-casting process. The 3D-aligned ABOw/epoxy composites consist of repetitively layered structures, and the microstructures of these composites are controlled by the filler content. The developed 3D-aligned ABOw/epoxy composite had a compressive strength 56.72% higher than that of pure epoxy, indicating that it can provide high durability when applied as a protective material for portable electronic devices.
Complex Protection of Some Steels in Sulfuric Acid Solutions by 1,2,4-Triazole Derivatives
Authors: Avdeev Yaroslav G. , Nenasheva Tatyana A. , Luchkin Andrey Yu. , Marshakov Andrey I. , Kuznetsov Yurii I.
Published: September 2024

The corrosion behavior of steels of various grades in sulfuric acid solutions with the addition of nitrogen-containing corrosion inhibitors has been studied. Compounds containing the 1,2,4-triazole moiety effectively protect low-carbon (St3, St20, 08PS), high-strength (70S2KhA), and stainless steels (1Kh18N9T) not only from corrosion but also from the hydrogen penetration into the metals in concentrated sulfuric acid solutions. In some cases, the degree of steel protection from corrosion by these compounds exceeded 99%. The possibility of creating mixed inhibitors for steel protection containing triazole derivatives and KI has been shown. The rate constants for the main steps of cathodic evolution and hydrogen penetration into steel in sulfuric acid solutions have been determined, and the subsurface concentrations of hydrogen in the metals have been calculated. Triazole derivatives were found to act as inhibitors of hydrogen absorption by steel in H2SO4 solution. The degree of protection of steel from hydrogen absorption can reach 97%. It has been shown that triazole derivatives act as complex inhibitors of steel corrosion in sulfuric acid solutions because, along with strong inhibition of metal corrosion, they prevent hydrogen absorption by steel.
Phycocyanin-Loaded Alginate-Based Hydrogel Synthesis and Characterization
Authors: Buliga Diana-Ioana , Mocanu Alexandra , Rusen Edina , Diacon Aurel , Toader Gabriela , Brincoveanu Oana , Călinescu Ioan , Boscornea Aurelian Cristian
Published: September 2024

Phycocyanin was extracted from Spirulina platensis using conventional extraction (CE), direct ultrasonic-assisted extraction (direct UAE), indirect ultrasonic-assisted extraction (indirect UAE), and microwave-assisted extraction (MAE) methods at different temperatures, extraction intervals, stirring rate, and power intensities while maintaining the same algae to solvent ratio (1:15 w/v). The optimization of the extraction parameters indicated that the direct UAE yielded the highest phycocyanin concentration (29.31 ± 0.33 mg/mL) and antioxidant activity (23.6 ± 0.56 mg TE/g algae), while MAE achieved the highest purity (Rp = 0.5 ± 0.002). Based on the RP value, phycocyanin extract obtained by MAE (1:15 w/v algae to solvent ratio, 40 min, 40 °C, and 900 rpm) was selected as active compound in an alginate-based hydrogel formulation designed as potential wound dressings. Phycocyanin extracts and loaded hydrogels were characterized by FT-IR analysis. SEM analysis confirmed a porous structure for both blank and phycocyanin loaded hydrogels, while the mechanical properties remained approximately unchanged in the presence of phycocyanin. Phycocyanin release kinetics was investigated at two pH values using Zero-order, First-order, Higuchi, and Korsmeyer-Peppas kinetics models. The Higuchi model best fitted the experimental results. The R2 value at higher pH was nearly 1, indicating a superior fit compared with lower pH values.
Comparative Analysis of Basal vs. Apical Left Ventricular Aneurysms: Impact on Ejection Fraction and Cardiac Function
Authors: Tomić Slobodan , Veljković Stefan , Šljivo Armin , Raičković Tatjana , Lakčević Jovana , Đokić Olivera , Peruničić Ana , Nikolić Aleksandra , Bojić Milovan
Published: September 2024

Background and Objectives: Left ventricular aneurysm (LVA) is associated with a decline in cardiac function, evidenced by a lower ejection fraction (EF), due to the reduction in the proportion of functional myocardium. The left ventricular end-diastolic volume (LVEDV), the left ventricular aneurysm volume (LVAV), and the LVAV/LVEDV ratio show a strong correlation with the EF. The aim of this study was to determine LVA characteristics post-myocardial infarction (basal vs. apical) and to evaluate the impact of aneurysm volume in diastole (LVAVd), aneurysm area in diastole (LVAAd), and their respective ratios with LVEDV and area (LVEDA) on the EF, in order to identify the most critical predictive factors for assessing and managing the negative impact of aneurysms on cardiac function. Materials and Methods: This observational study included post-infarction LVA patients at the “Dedinje” Cardiovascular Institute in Belgrade, Serbia, undergoing routine transthoracic echocardiography. Echocardiography assessed volumes (LVEDV, LVESV, LVAVd, LVAVs) and areas (LVAAd, LVAAs, LVEDA, LVESA) using the area–length method. The ratios (LVAVd/LVEDV, LVAVs/LVESV, LVAAd/LVEDA, LVAAs/LVESA) were derived from these measures. The left ventricular EF was calculated using Simpson’s method. Results: Basal aneurysms showed a significantly smaller LVAVd (p = 0.016), LVAAd (p = 0.003), and LVAAs (p = 0.029) compared to apical aneurysms, indicating that basal aneurysms are smaller in size. However, there was no significant difference in the EF and overall LV volumes between the groups, although the basal aneurysm group had a slightly higher EF and end-diastolic volume, with a slightly lower end-systolic volume. Furthermore, when comparing the correlation between the EF and the LVAVd, the LVEDV, and the LVAVd/LVEDV ratio, the results indicate that the LVAVd had the greatest impact on the EF (−0.695), followed by the LVAVd/LVEDV ratio (−0.637), and the lowest correlation is between the EF and LVEDV. A similar relationship is observed when comparing the EF with the LVESV, the LVAVs, and the LVAVs/LVESV ratio. Conclusions: Basal aneurysms are significantly smaller than apical ones, yet EF and LV volumes remain similar between the groups, with the EF being slightly higher in the basal group. In cases of LVA, LVAVd shows the strongest negative correlation with the EF, indicating its significant impact on systolic function, followed by the LVAVd/LVEDV ratio, with the weakest correlation seen between the EF and LVEDV.
Diosmin and Hesperidin Have a Protective Effect in Diabetic Neuropathy via the FGF21 and Galectin-3 Pathway
Authors: Gölboyu Birzat Emre , Erdoğan Mümin Alper , Çoşar Mehmet Ali , Balıkoğlu Ezgi , Erbaş Oytun
Published: September 2024

Background and Objectives: This study aimed to investigate the protective effect of diosmin and hesperidin in diabetic neuropathy using a rat model, focusing on their impact on nerve regeneration through the fibroblast growth factor 21 (FGF21) and galectin-3 (gal3) pathway. Materials and Methods: Forty adult male Wistar rats were used in this study. Diabetes was induced using streptozotocin (STZ), and the rats were divided into control, diabetes and saline-treated, diabetes and diosmin + hesperidin (150 mg/kg) treated, and diabetes and diosmin + hesperidin (300 mg/kg) treated groups. Electromyography (EMG) and inclined plane testing were performed to assess nerve function and motor performance. Sciatic nerve sections were examined histopathologically. Plasma levels of FGF21, galectin-3, and malondialdehyde (MDA) were measured as markers of oxidative stress and inflammation. Results: Diabetic rats treated with saline displayed reduced nerve conduction parameters and impaired motor performance compared to controls. Treatment with diosmin and hesperidin significantly improved compound muscle action potential (CMAP) amplitude, distal latency, and motor performance in a dose-dependent manner. Histopathological examination revealed decreased perineural thickness in treated groups. Additionally, treatment with diosmin and hesperidin resulted in increased plasma FGF21 levels and reduced plasma levels of galectin-3 and MDA, indicating decreased oxidative stress and inflammation. Conclusions: Diosmin and hesperidin exhibited protective effects in diabetic neuropathy by promoting nerve regeneration, enhancing nerve conduction, and improving motor performance. These effects were associated with modulation of the FGF21 and galectin-3 pathway. These findings suggest that diosmin and hesperidin may hold potential as adjunctive therapies for diabetic neuropathy.
Optimizing Cardiac Rehabilitation in Heart Failure: Comprehensive Insights, Barriers, and Future Strategies
Authors: Epelde Francisco
Published: September 2024

Heart failure (HF) is a prevalent cardiovascular disease associated with significant morbidity, mortality, and healthcare costs. Cardiac rehabilitation (CR) is a structured, multidisciplinary intervention that has been proven to improve functional capacity, reduce hospital readmissions, and enhance the quality of life in HF patients. Despite strong clinical evidence and guideline endorsements, CR remains underutilized in this population. This paper provides a comprehensive review of the role of CR in HF, focusing on exercise-based rehabilitation, psychosocial support, and education. It also explores the barriers to CR implementation, such as patient-related factors, provider-related issues, and systemic challenges. Additionally, we propose future strategies to increase CR uptake, including personalized CR programs, telehealth innovations, and integrating CR into routine HF care pathways. By addressing these challenges and implementing these strategies, healthcare systems can optimize CR delivery and improve outcomes for HF patients.
Enhanced Pollutant Removal and Antifouling in an Aerobic Ceramic Membrane Bioreactor with Bentonite for Pharmaceutical Wastewater Treatment
Authors: Elmoutez Salaheddine , Ayyoub Hafida , Necibi Mohamed Chaker , Elmidaoui Azzedine , Taky Mohamed
Published: September 2024

This study examined the impact of adding bentonite clay (concentration of 1.5 to 10 g/L) to a pilot-scale aerobic ceramic membrane bioreactor (AeCMBR) for treating pharmaceutical wastewater (PhWW). The hydraulic retention time (HRT) was maintained at 24 h; the dissolved oxygen was between 2 mg/L (on) and 4 mg/L (off) throughout operation. Organic and nitrogen pollution removal rates and heavy metal (Cu, Ni, Pb, Zn) reduction rates were assessed. The chemical oxygen demand (COD) removal efficiency exceeded 82%. Adsorption improved ammonia (NH4+) removal to 78%; the addition of 5 g of bentonite resulted in a 38% improvement compared with the process without bentonite. The average nitrate concentration decreased from 169.69 mg/L to 43.72 mg/L. The average removal efficiencies for Cu, Ni, Pb and Zn were 86%, 68.52%, 46.90% and 56.76%, respectively. Bentonite at 5 g/L significantly reduced membrane fouling. The cost–benefit analysis enabled us to predict that the process will meet the multiple objectives of durability, treatment performance and economic viability. The combination of an AeCMBR and bentonite adsorption has proven to be a valuable solution for treating highly polluted wastewater.
Miniature Tensile and Small Punch Testing: Mechanical Performance and Application in Hydrogen Embrittlement Analysis
Authors: Tao Ping , Zhou Wei , Miao Xinting , Peng Jian , Liu Xuedong
Published: September 2024

The utilization of micro-sample testing has demonstrated its effectiveness in conducting quantitative research on mechanical properties, damage evolutions and fracture features. For in-service equipment, millimicron sampling allows for non-destructive testing and analysis of mechanical performance evolution during operation. This paper presents a comparative study of the miniature uniaxial tensile test (MUTT) and small punch test (SPT) by experimental and finite element methods. As a comparison, the standard conventional-size tensile tests were also carried out. Detailed analyses of the elastoplastic behaviors and damage evolutions of MUTT and SPT were presented, followed by an application case illustrating the characterization of hydrogen embrittlement sensitivity based on MUTT and SPT. An inverse finite element modeling method of load–displacement curve reproduction was used to calibrate the variations of damage parameters of hydrogen-charged MUTT and SPT specimens. Hydrogen embrittlement (HE) indexes were determined by using different calculation methods. The results reveal that the HE sensitivity estimated by MUTT is higher than that measured by SPT, which is related to the different deformation processes and strain rates of the two testing methods.
Struggling to Understand the NEC Spectrum—Could the Integration of Metabolomics, Clinical-Laboratory Data, and Other Emerging Technologies Help Diagnosis?
Authors: Sarafidis Kosmas , Agakidou Eleni , Kontou Angeliki , Agakidis Charalampos , Neu Josef
Published: September 2024

Necrotizing enterocolitis (NEC) is the most prevalent and potentially fatal intestinal injury mainly affecting premature infants, with significant long-term consequences for those who survive. This review explores the scale of the problem, highlighting advancements in epidemiology, the understanding of pathophysiology, and improvements in the prediction and diagnosis of this complex, multifactorial, and multifaced disease. Additionally, we focus on the potential role of metabolomics in distinguishing NEC from other conditions, which could allow for an earlier and more accurate classification of intestinal injuries in infants. By integrating metabolomic data with other diagnostic approaches, it is hoped to enhance our ability to predict outcomes and tailor treatments, ultimately improving care for affected infants.
Vertical Structure of Heavy Rainfall Events in Brazil
Authors: Gatti Eliana Cristine , da Costa Izabelly Carvalho , Vila Daniel
Published: September 2024

Intense rainfall events frequently occur in Brazil, often leading to rapid flooding. Despite their recurrence, there is a notable lack of sub-daily studies in the country. This research aims to assess patterns related to the structure and microphysics of clouds driving intense rainfall in Brazil, resulting in high accumulation within 1 h. Employing a 40 mm/h threshold and validation criteria, 83 events were selected for study, observed by both single and dual-polarization radars. Contoured Frequency by Altitude Diagrams (CFADs) of reflectivity, Vertical Integrated Liquid (VIL), and Vertical Integrated Ice (VII) are employed to scrutinize the vertical cloud characteristics in each region. To address limitations arising from the absence of polarimetric coverage in some events, one case study focusing on polarimetric variables is included. The results reveal that the generating system (synoptic or mesoscale) of intense rain events significantly influences the rainfall pattern, mainly in the South, Southeast, and Midwest regions. Regional CFADs unveil primary convective columns with 40–50 dBZ reflectivity, extending to approximately 6 km. The microphysical analysis highlights the rapid structural intensification, challenging the event predictability and the issuance of timely, specific warnings.
A Comprehensive Review of Group-III Nitride Light-Emitting Diodes: From Millimeter to Micro-Nanometer Scales
Authors: Fan Xinye , Shi Jiawang , Chen Yiren , Miao Guoqing , Jiang Hong , Song Hang
Published: September 2024

This review describes the development history of group-III nitride light-emitting diodes (LEDs) for over 30 years, which has achieved brilliant achievements and changed people′s lifestyles. The development process of group-III nitride LEDs is the sum of challenges and solutions constantly encountered with shrinking size. Therefore, this paper uses these challenges and solutions as clues for review. It begins with reviewing the development of group-III nitride materials and substrates. On this basis, some key technological breakthroughs in the development of group-III nitride LEDs are reviewed, mainly including substrate pretreatment and p-type doping in material growth, the proposal of new device structures such as nano-LED and quantum dot (QD) LED, and the improvement in luminous efficiency, from the initial challenge of high-efficiency blue luminescence to current challenge of high-efficiency ultraviolet (UV) and red luminescence. Then, the development of micro-LEDs based on group-III nitride LEDs is reviewed in detail. As a new type of display device, micro-LED has drawn a great deal of attention and has become a research hotspot in the current international display area. Finally, based on micro-LEDs, the development trend of nano-LEDs is proposed, which is greener and energy-saving and is expected to become a new star in the future display field.
A Polyimide Composite-Based Electromagnetic Cantilever Structure for Smart Grid Current Sensing
Authors: Guler Zeynel , Jackson Nathan
Published: September 2024

Polyimides (PIs) have been extensively used in thin film and micro-electromechanical system (MEMS) processes based on their excellent thermal and mechanical stability and high glass transition temperature. This research explores the development of a novel multilayer and multifunctional polymer composite electro-piezomagnetic device that can function as an energy harvester or sensor for current-carrying wires or magnetic field sensing. The devices consist of four layers of composite materials with a polyimide matrix. The composites have various nanoparticles to alter the functionality of each layer. Nanoparticles of Ag were used to increase the electrical conductivity of polyimide and act as electrodes; lead zirconate titanate was used to make the piezoelectric composite layer; and either neodymium iron boron (NdFeB) or Terfenol-D was used to make the magnetic and magnetostrictive composite layer, which was used as the proof mass. A novel all-polymer multifunctional polyimide composite cantilever was developed to operate at low frequencies. This paper compares the performance of the different magnetic masses, shapes, and concentrations, as well as the development of an all-magnetostrictive device to detect voltage or current changes when coupled to the magnetic field from a current-carrying wire. The PI/PZT cantilever with the PI/NdFeB proof mass demonstrated higher voltage output compared to the PI/Terfenol-D proof mass device. However, the magnetostrictive composite film could be operated without a piezoelectric film based on the Villari effect, which consisted of a single PI-Terfenol-D film. The paper illustrates the potential to develop an all-polymer composite MEMS device capable of acting as a magnetic field or current sensor.
Characteristics of Lithium Deposits in Mongolia
Authors: Dostal Jaroslav , Gerel Ochir
Published: September 2024

Lithium is a strategic metal due to its use in green technologies, particularly battery manufacturing. It is on the US List of Critical Minerals and the European Union’s List of Critical Raw Materials. In Mongolia, there are three major types of potentially economic Li deposits: (1) Deposits related to granites, granitic pegmatites and associated rocks; (2) Li-rich clay deposits; (3) Salar (Li brine) deposits. The first type of mineralization is associated with the lithium–fluorine-rich peraluminous A-type granites and related rocks (greisens, pegmatites, ongonites, ongorhyolites). The mineralization includes Li and also Sn, W, Ta and Nb. Lithium is hosted in Li-rich micas, unlike the world-class Li-bearing pegmatite deposits where the bulk of Li is in spodumene. In Mongolia, particularly promising are Li brines of endorheic basins in the Gobi Desert with an arid environment, high evaporation rates and low precipitation.
Study of Hydrometallurgical Treatment of Metal-Bearing Material from Environmental Burdens Containing Iron, Chromium, Nickel, and Cobalt
Authors: Laubertová Martina , Velgosova Oksana , Sisol Martin , Vindt Tomáš
Published: September 2024

In Slovakia, around 200 environmental burdens that contain a significant amount of usable raw materials were created by the extraction of ores or the dumping of industrial waste. In this research, the hydrometallurgical metal recovery method from a metal-bearing environmental landfill in Sereď was investigated. The analysis of a representative sample of waste obtained from this landfill proved the presence of significant amounts of metals (43.45% Fe; 1.3% Cr; 0.09% Co, and 0.23% Ni). A thermodynamic study of the metals’ (Fe, Cr, Ni, and Co) leaching probability confirmed the possibility of metal extraction in an acidic environment. Subsequently, the effect of the most important factors on the leaching process (stirring intensity, temperature, liquid-to-solid phase ratio, and acid concentration) was experimentally tested. The analysis of the results determined the optimal leaching conditions. The extraction of 90.35% Fe and 59.62% Cr was ensured at a stirring intensity of 400 rpm, a leaching temperature of 80 °C, a liquid-to-solid phase ratio of 40, and a H2SO4 concentration of 3 mol/dm3. Various techniques, including SEM, EDX, XRD, Eh-pH diagrams, and AAS analysis, were used to analyze samples and products after leaching. The possibility of precipitating metals/compounds from the leachate to obtain a marketable product was theoretically proposed and proven.
Development of a Tool for Evaluating the Influence of Engineering Students’ Perception of Generative AI on University Courses Based on Personality, Perceived Roles in Design Teams, and Course Engagement
Authors: Filippi Stefano , Motyl Barbara
Published: September 2024

This research investigates the possible influence of students’ perceptions of emerging AI technologies on university courses, focusing on their knowledge and perceived usefulness within engineering design. An evaluation tool implemented in a Microsoft Excel workbook was developed and tested to perform the process of data collection through well-known questionnaires, data analysis, and the generation of results, facilitating attention to class compositions and measuring AI awareness and perceived usefulness. The study considers traditional aspects such as roles within design teams and the psychological factors that may influence these roles, alongside contemporary topics like Large Language Models (LLMs). Questionnaires based on well-established theories were administered during courses on product innovation and representation, assessing both primary and secondary design roles. Primary roles focus on technical skills and knowledge, while secondary roles emphasize problem-solving approaches. The Big Five questionnaire was used to characterize students’ psychological profiles based on the main personality traits. Students’ perceptions of AI involvement and usefulness in engineering design were evaluated using questionnaires derived from the consolidated literature as well. Data were collected via Google forms from both in-class and off-line students. The first results of the workbook adoption highlight some relationships between personality traits, perceived roles in design teams, and AI knowledge and usefulness. These findings aim to help educators enhance course effectiveness and align courses with current AI advancements. The workbook is available to the readers to collect data and perform analyses in different countries, education disciplines, and as time goes by, in order to add the longitudinal point of view to the research.
An Optimization Strategy for Security and Reliability in a Diamond Untrusted Relay Network with Cooperative Jamming
Authors: Qian Shen , Cheng Meng
Published: September 2024

This paper tackles the challenge of secure and reliable data transmission in diamond network configurations featuring two untrusted relays with low-security clearance. We propose an innovative approach that employs lossy-decode and -forward relaying at these untrusted relays to boost transmission reliability while safeguarding the source information from potential eavesdroppers. An essential contribution of this work is the introduction of the reliable and secure probability (RSP) metric. This metric assesses the likelihood of the destination successfully retrieving the original information while maintaining its confidentiality from untrusted relays. Our analysis shows that the integration of cooperative jamming signals markedly enhances the RSP, resulting in superior security and reliability. Simulation results confirm that optimal power distribution among the source, relays, and destination further maximizes the RSP. These findings underscore the effectiveness of our proposed scheme in ensuring secure and reliable communication in environments with untrusted relays, suggesting its potential as a robust solution for secure communications in diamond network configurations.
Blockchain-Based E-Voting Mechanisms: A Survey and a Proposal
Authors: Sharp Matthew , Njilla Laurent , Huang Chin-Tser , Geng Tieming
Published: September 2024

Advancements in blockchain technology and network technology are bringing in a new era in electronic voting systems. These systems are characterized by enhanced security, efficiency, and accessibility. In this paper, we compose a comparative analysis of blockchain-based electronic voting (e-voting) systems using blockchain technology, cryptographic techniques, counting methods, and security requirements. The core of the analysis involves a detailed examination of blockchain-based electronic voting systems, focusing on the variations in architecture, cryptographic techniques, vote counting methods, and security. We also introduce a novel blockchain-based e-voting system, which integrates advanced methodologies, including the Borda count and Condorcet method, into e-voting systems for improved accuracy and representation in vote tallying. The system’s design features a flexible and amendable blockchain structure, ensuring robustness and security. Practical implementation on a Raspberry Pi 3 Model B+ demonstrates the system’s feasibility and adaptability in diverse environments. Our study of the evolution of e-voting systems and the incorporation of blockchain technology contributes to the development of secure, transparent, and efficient solutions for modern democratic governance.
Nitrate Removal by Floating Treatment Wetlands under Aerated and Unaerated Conditions: Field and Laboratory Results
Authors: McCoy Jenna , Chaffee Matt , Mittelstet Aaron , Messer Tiffany , Comfort Steve
Published: September 2024

Urban and storm water retention ponds eventually become eutrophic after years of receiving runoff water. In 2020, a novel biological and chemical treatment was initiated to remove accumulated nutrients from an urban retention pond that had severe algae and weed growth. Our approach installed two 6.1 m × 6.1 m floating treatment wetlands (FTWs) and two airlift pumps that contained slow-release lanthanum composites, which facilitated phosphate precipitation. Four years of treatment (2020–2023) resulted in median nitrate-N concentrations decreasing from 23 µg L−1 in 2020 to 1.3 µg L−1 in 2023, while PO4-P decreased from 42 µg L−1 to 19 µg L−1. The removal of N and P from the water column coincided with less algae, weeds, and pond muck (sediment), and greater dissolved oxygen (DO) concentrations and water clarity. To quantify the sustainability of this bio-chemical approach, we focused on quantifying nitrate removal rates beneath FTWs. By enclosing quarter sections (3.05 × 3.05 m) of the field-scale FTWs inside vinyl pool liners, nitrate removal rates were measured by spiking nitrate into the enclosed root zone. The first field experiment showed that DO concentrations inside the pool liners were well below the ambient values of the pond (<0.5 mg/L) and nitrate was quickly removed. The second field experiment quantified nitrate loss under a greater range of DO values (<0.5–7 mg/L) by including aeration as a treatment. Nitrate removal beneath FTWs was roughly one-third less when aerated versus unaerated. Extrapolating experimental removal rates to two full-sized FTWs installed in the pond, we estimate between 0.64 to 3.73 kg of nitrate-N could be removed over a growing season (May–September). Complementary laboratory mesocosm experiments using similar treatments to field experiments also exhibited varying nitrate removal rates that were dependent on DO concentrations. Using an average annual removal rate of 1.8 kg nitrate-N, we estimate the two full-size FTWs could counter 14 to 56% of the annual incoming nitrate load from the contributing watershed.
Dietary Patterns by Level of Maternal Education and Their Contribution to BMI, Fat Mass Index, and Fat-Free Mass Index at Age 5 and the Longitudinal Association with BMI at Age 10
Authors: Rashid Viyan , Nicolaou Mary , Verhoeff Arnoud P. , Weijs Peter J. M. , Streppel Martinette T.
Published: September 2024

Background: Our aim was to identify dietary patterns by the level of maternal education that contribute to BMI, fat mass index (FMI), and fat-free mass index (FFMI) in children at age 5 and to assess if these dietary patterns are related to BMI at age 10. Methods: Per group (low/middle/high level), Reduced Rank Regression (RRR) was used to derive dietary patterns for the response variables BMI z-score, FMI, and FFMI in 1728 children at age 5 in the Amsterdam Born Children and their Development (ABCD) cohort. Regression analyses were then used to determine the association with BMI at age 10. Results: In each group, pattern 1 was characterized by its own cluster of food groups. Low: water/tea, savory snacks, sugar, low-fat meat, and fruits; middle: water/tea, low-fat cheese, fish, low-fat dairy, fruit drink, low-fat meat, and eggs; and high: low-fat cheese, fruits, whole-grain breakfast products, and low-fat and processed meat. Additionally, in each group, pattern 1 was positively associated with BMI z-scores at age 10 (low: β ≤ 0.43 [95% CI ≤ 0.21; 0.66], p < 0.001, middle: β ≤ 0.23 [0.09; 0.36], p ≤ 0.001, and high: β ≤ 0.24 [0.18; 0.30], p < 0.001). Conclusions: The dietary patterns stratified by the level of maternal education are characterized by different food groups. But in all the groups, pattern 1 is positively associated with BMI at age 10.
Influence of Type 2 Diabetes and Adipose Tissue Dysfunction on Breast Cancer and Potential Benefits from Nutraceuticals Inducible in Microalgae
Authors: Sergi Domenico , Melloni Mattia , Passaro Angelina , Neri Luca Maria
Published: September 2024

Breast cancer (BC) represents the most prevalent cancer in women at any age after puberty. From a pathogenetic prospective, despite a wide array of risk factors being identified thus far, poor metabolic health is emerging as a putative risk factor for BC. In particular, type 2 diabetes mellitus (T2DM) provides a perfect example bridging the gap between poor metabolic health and BC risk. Indeed, T2DM is preceded by a status of hyperinsulinemia and is characterised by hyperglycaemia, with both factors representing potential contributors to BC onset and progression. Additionally, the aberrant secretome of the dysfunctional, hypertrophic adipocytes, typical of obesity, characterised by pro-inflammatory mediators, is a shared pathogenetic factor between T2DM and BC. In this review, we provide an overview on the effects of hyperglycaemia and hyperinsulinemia, hallmarks of type 2 diabetes mellitus, on breast cancer risk, progression, treatment and prognosis. Furthermore, we dissect the role of the adipose-tissue-secreted adipokines as additional players in the pathogenesis of BC. Finally, we focus on microalgae as a novel superfood and a source of nutraceuticals able to mitigate BC risk by improving metabolic health and targeting cellular pathways, which are disrupted in the context of T2DM and obesity.
RETRACTED: Ghasemi Darestani et al. Association of Polyunsaturated Fatty Acid Intake on Inflammatory Gene Expression and Multiple Sclerosis: A Systematic Review and Meta-Analysis. Nutrients 2022, 14, 4627
Authors:   Nutrients Editorial Office
Published: September 2024

The Journal retracts and amends the authorship of the article “Association of Polyunsaturated Fatty Acid Intake on Inflammatory Gene Expression and Multiple Sclerosis: A Systematic Review and Meta-Analysis” [...]
Breastfeeding: Benefits to Infant and Mother
Authors: Roghair Robert
Published: September 2024

The provision of human milk to newborn infants is one of the most effective ways to reduce infant mortality [...]
The Adverse Impact of Bisphenol A Exposure on Optimal Cardiovascular Health as Measured by Life’s Essential 8 in U.S. Adults: Evidence from NHANES 2005 to 2016
Authors: Chen Yemei , Xu Chao , Huang Ying , Liu Zhaoyan , Zou Jiupeng , Zhu Huilian
Published: September 2024

Background/Objectives: Cardiovascular diseases are the primary cause of global morbidity and mortality, with cardiovascular health (CVH) remaining well below the ideal level and showing minimal improvement in the U.S. population over recent years. Bisphenol A (BPA), a pervasive environmental contaminant, has emerged as a potential contributor to adverse cardiovascular outcomes. This cross-sectional study delves into the impact of BPA exposure on achieving optimal CVH, as assessed by the Life’s Essential 8 metric, among U.S. adults. Methods: Analyzing data from 6635 participants in the National Health and Nutrition Examination Survey (NHANES) collected between 2005 and 2016, BPA exposure was quantified through urinary BPA levels, while optimal CVH was defined using the American Heart Association’s Life’s Essential 8 criteria, scoring between 80 and 100. Multivariable logistic regression and propensity score matching were employed to evaluate the association between BPA exposure and CVH. Results: This study reveals that individuals in the highest tertile of urinary BPA levels were 27% less likely to attain optimal CVH compared with those in the lowest tertile (OR, 0.73; 95% CI: 0.59–0.92). This negative association persisted across diverse demographics, including age, sex, and race, mirrored in the link between urinary BPA levels and health factor scores. Conclusions: The findings underscore the potential benefits of reducing BPA exposure in enhancing the prevalence of optimal CVH and mitigating the burden of cardiovascular disease. Given the widespread use of BPA, ongoing monitoring of BPA’s impact on CVH is essential. Further studies are necessary to elucidate the long-term and causative connections between BPA and CVH. These insights contribute to understanding the complex interplay between environmental factors and CVH outcomes, informing targeted interventions to mitigate cardiovascular disease risk within the population.
Severity Ranking of Missense and Frameshift Genetic Variants in SCD1 by In Silico and In Vitro Functional Analysis
Authors: Susán Hanna K. , Orosz Gabriella , Zámbó Veronika , Csala Miklós , Kereszturi Éva
Published: September 2024

Background: A considerable proportion of the symptoms associated with excessive dietary intake can be attributed to systemic imbalances in lipid metabolism. The prominent toxicity of saturated fatty acids has been repeatedly demonstrated and sheds light on the protective role of stearoyl-CoA desaturase-1 (SCD1), the key enzyme for fatty acid desaturation. SCD1 protein expression is regulated at the levels of transcription, translation, and degradation. However, the modulating effect of the variability of the human genome must also be taken into account. Therefore, we aimed to ascertain whether natural missense or frameshift mutations in SCD1 (p.H125P, p.M224L, p.A333T, p.R253AfsTer7) could influence the expression, degradation, or function of the enzyme. Methods: In silico and in vitro experiments were conducted to comprehensively evaluate the consequences associated with each genetic variation, with the objective of using the results to propose a risk or severity ranking of SCD1 variants. Results: As anticipated, the p.R253AfsTer7 variant was identified as the most deleterious in structural, functional, and quantitative terms. The p.H125P variant also reduced the desaturation capacity of the enzyme in accordance with the predicted structural alterations and augmented degradation resulting from folding complications. This was aggravated by increased mRNA instability and accompanied by mild endoplasmic reticulum stress induction. The p.A333T protein exhibited an intermediate phenotype, whereas p.M224L showed no deleterious effects and even increased the amount of SCD1. Conclusions: In conclusion, the large-scale identification of genetic variations needs to be supplemented with comprehensive functional characterization of these variations to facilitate adequate personalized prevention and treatment of lipid metabolism-related conditions.
EZH2-Mediated H3K27 Trimethylation in the Liver of Mice Is an Early Epigenetic Event Induced by High-Fat Diet Exposure
Authors: Pinton Giulia , Perucca Mattia , Gigliotti Valentina , Mantovani Elena , Clemente Nausicaa , Malecka Justyna , Chrostek Gabriela , Dematteis Giulia , Lim Dmitry , Moro Laura , Chiazza Fausto
Published: September 2024

Background/Objectives: Methyltransferase EZH2-mediated H3K27me3 is involved in liver inflammation and fibrosis, but its role in hepatic metabolic derangements is not yet clearly defined. We investigated if a high-fat diet (HFD) induced early changes in EZH2 expression and H3K27 me3 in the liver of mice. Methods: Five-week-old mice were fed an HFD or a low-fat diet (Control) for 2 weeks (2 W) or 8 weeks (8 W). Body weight was recorded weekly. Glycemia and oral glucose tolerance were assessed at baseline and after 2 W–8 W. Finally, livers were collected for further analysis. Results: As expected, mice that received 8 W HFD showed an increase in body weight, glycemia, and liver steatosis and an impairment in glucose tolerance; no alterations were observed in 2 W HFD mice. Eight weeks of HFD caused hepatic EZH2 nuclear localization and increased H3 K27me3; surprisingly, the same alterations occurred in 2 W HFD mice livers, even before overweight onset. We demonstrated that selective EZH2 inhibition reduced H3K27me3 and counteracted lipid accumulation in HUH-7 cells upon palmitic acid treatment. Conclusions: In conclusion, we point to EZH2/H3K27me3 as an early epigenetic event occurring in fatty-acid-challenged livers both in vivo and in vitro, thus establishing EZH2 as a potential pharmacological target for metabolic derangements.
Lifestyle Intervention to Promote an Adequate Gestational Weight Gain and Improve Perinatal Outcomes in a Cohort of Obese Women
Authors: Menichini Daniela , Spelta Eleonora , Monari Francesca , Petrella Elisabetta , Facchinetti Fabio , Neri Isabella
Published: September 2024

Objective: This study aims to evaluate the correlation of gestational weight gain (GWG) with pregnancy and perinatal outcomes in a cohort of obese women class I-III receiving standard care (SC) or lifestyle intervention (LI). Methods: This is a prospective cohort study including singleton obese women (body mass index, BMI ≥ 30) who delivered between 2016 and 2020. Women exposed to a LI were referred to an obesity weight management ad hoc clinic. Women followed by family centers or private settings represented the SC group. The LI started between the 9 and 12th week, consisting of a low-calorie diet and physical activity program. Pregnancy and perinatal outcomes were prospectively collected. Women included in the SC group were followed, simply checking their pregnancy and health status, providing general recommendations on a healthy lifestyle in pregnancy. GWG was categorized as insufficient, adequate, or excessive according to the Institute of Medicine (IOM). Results: A total of 1874 obese singleton women delivered in the study period. Among them, 565 (30.1%) were included in the LI while 1309 received SC. Women in SC showed a higher rate of GWG out of the IOM recommendations (excessive/insufficient), while women in the LI group showed higher adequate GWG. The small-for-gestational-age (SGA) rate resulted to be higher in the SC group. Once adjusting for age, BMI, country of origin, provider, and gestational hypertension, the risk for SGA was increased by insufficient GWG (OR = 1.25; 95%CI: 1.03–1.59), while it was reduced by LI (OR = 0.67, 95%CI: 0.42–0.98). Conclusions: In a cohort of obese women, the exposure to an LI was associated with more adequate GWG, reduced insufficient weight gain, and a decreased risk of SGA infants.