bluuebunny/crossref_metadata_2025 huggingface dataset:
Graphene Oxide–Silver Nanoparticles Nanocomposite Stimulates Differentiation in Human Neuroblastoma Cancer Cells (SH-SY5Y)
Authors: Gurunathan Sangiliyandi , Kim Jin-Hoi
Published: November 2017

Recently, graphene and graphene related nanocomposite receive much attention due to high surface-to-volume ratio, and unique physiochemical and biological properties. The combination of metallic nanoparticles with graphene-based materials offers a promising method to fabricate novel graphene–silver hybrid nanomaterials with unique functions in biomedical nanotechnology, and nanomedicine. Therefore, this study was designed to prepare graphene oxide (GO) silver nanoparticles (AgNPs) nanocomposite (GO-AgNPs) containing two different nanomaterials in single platform with distinctive properties using luciferin as reducing agents. In addition, we investigated the effect of GO-AgNPs on differentiation in SH-SY5Y cells. The synthesized GO-AgNPs were characterized by ultraviolet-visible absorption spectroscopy (UV-vis), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Raman spectroscopy. The differentiation was confirmed by series of cellular and biochemical assays. The AgNPs were distributed uniformly on the surface of graphene oxide with an average size of 25 nm. As prepared GO-AgNPOs induces differentiation by increasing the expression of neuronal differentiation markers and decreasing the expression of stem cell markers. The results indicated that the redox biology involved the expression of various signaling molecules, which play an important role in differentiation. This study suggests that GO-AgNP nanocomposite could stimulate differentiation of SH-SY5Y cells. Furthermore, understanding the mechanisms of differentiation of neuroblastoma cells could provide new strategies for cancer and stem cell therapies. Therefore, these studies suggest that GO-AgNPs could target specific chemotherapy-resistant cells within a tumor.
Aberrant Lipid Metabolism in Hepatocellular Carcinoma Revealed by Liver Lipidomics
Authors: Li Zhao , Guan Ming , Lin Yu , Cui Xiao , Zhang Yangyang , Zhao Zhenwen , Zhu Jiye
Published: November 2017

Background: The aim of this study was to characterize the disorder of lipid metabolism in hepatocellular carcinoma (HCC). HCC is a worldwide disease. The research into the disorder of lipid metabolism in HCC is very limited. Study of lipid metabolism in liver cancer tissue may have the potential to provide new insight into HCC mechanisms. Methods: A lipidomics study of HCC based on Ultra high performance liquid chromatography-electronic spray ionization-QTOF mass spectrometer (UPLC-ESI-QTOF MS) and Matrix assisted laser desorption ionization-fourier transform ion cyclotron resonance mass spectrometer (MALDI-FTICR MS) was performed. Results: Triacylglycerols (TAGs) with the number of double bond (DB) > 2 (except 56:5 and 56:4 TAG) were significantly down-regulated; conversely, others (except 52:2 TAG) were greatly up-regulated in HCC tissues. Moreover, the more serious the disease was, the higher the saturated TAG concentration and the lower the polyunsaturated TAG concentration were in HCC tissues. The phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylinositol (PI) were altered in a certain way. Sphingomyelin (SM) was up-regulated and ceramide (Cer) were down-regulated in HCC tissues. Conclusions: To our knowledge, this is the first such report showing a unique trend of TAG, PC, PE and PI. The use of polyunsaturated fatty acids, like eicosapentanoic and docosahexanoic acid, as supplementation, proposed for the treatment of Non-alcoholic steatohepatitis (NASH), may also be effective for the treatment of HCC.
Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment
Authors: Choi Ji , Jang Jun , Son Dong , Im Hyung-Sik , Kim Ji , Park Joung , Choi Won , Han Sang-Bae , Hong Jin
Published: November 2017

Oxidative stress and neuroinflammation are implicated in the development and pathogenesis of Alzheimer’s disease (AD). Here, we investigated the anti-inflammatory and antioxidative effects of krill oil. Oil from Euphausia superba (Antarctic krill), an Antarctic marine species, is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). We examined whether krill oil diet (80 mg/kg/day for one month) prevents amyloidogenesis and cognitive impairment induced by intraperitoneal lipopolysaccharide (LPS) (250 µg/kg, seven times daily) injections in AD mice model and found that krill oil treatment inhibited the LPS-induced memory loss. We also found that krill oil treatment inhibited the LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and decreased reactive oxygen species (ROS) and malondialdehyde levels. Krill oil also suppresses IκB degradation as well as p50 and p65 translocation into the nuclei of LPS-injected mice brain cells. In association with the inhibitory effect on neuroinflammation and oxidative stress, krill oil suppressed amyloid beta (1–42) peptide generation by the down-regulating APP and BACE1 expression in vivo. We found that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (50 and 100 µM) dose-dependently decreased LPS-induced nitric oxide and ROS generation, and COX-2 and iNOS expression as well as nuclear factor-κB activity in cultured microglial BV-2 cells. These results suggest that krill oil ameliorated impairment via anti-inflammatory, antioxidative, and anti-amyloidogenic mechanisms.
Pharmacokinetics of Chlorin e6-Cobalt Bis(Dicarbollide) Conjugate in Balb/c Mice with Engrafted Carcinoma
Authors: Volovetsky Arthur , Sukhov Vladimir , Balalaeva Irina , Dudenkova Varvara , Shilyagina Natalia , Feofanov Аlexey , Efremenko Anastasija , Grin Mikhail , Mironov Andrey , Sivaev Igor , Bregadze Vladimir , Maslennikova Anna
Published: November 2017

The necessary precondition for efficient boron neutron capture therapy (BNCT) is control over the content of isotope 10B in the tumor and normal tissues. In the case of boron-containing porphyrins, the fluorescent part of molecule can be used for quantitative assessment of the boron content. Study Objective: We performed a study of the biodistribution of the chlorin e6-Cobalt bis(dicarbollide) conjugate in carcinoma-bearing Balb/c mice using ex vivo fluorescence imaging, and developed a mathematical model describing boron accumulation and release based on the obtained experimental data. Materials and Methods: The study was performed on Balb/c tumor-bearing mice (CT-26 tumor model). A solution of the chlorin e6-Cobalt bis(dicarbollide) conjugate (CCDC) was injected into the blood at a dose of 10 mg/kg of the animal’s weight. Analysis of the fluorescence signal intensity was performed at several time points by spectrofluorimetry in blood and by laser scanning microscopy in muscle, liver, and tumor tissues. The boron content in the same samples was determined by mass spectroscopy with inductively coupled plasma. Results: Analysis of a linear approximation between the fluorescence intensity and boron content in the tissues demonstrated a satisfactory value of approximation reliability with a Spearman’s rank correlation coefficient of r = 0.938, p < 0.01. The dynamics of the boron concentration change in various organs, calculated on the basis of the fluorescence intensity, enabled the development of a model describing the accumulation of the studied compound and its distribution in tissues. The obtained results reveal a high level of correspondence between the model and experimental data.
Effect of Dietary Acidolysis-Oxidized Konjac Glucomannan Supplementation on Serum Immune Parameters and Intestinal Immune-Related Gene Expression of Schizothorax prenanti
Authors: Chen Mingrui , Wang Shuyao , Liang Xue , Ma Donghui , He Li , Liu Yaowen
Published: November 2017

The present study was conducted to investigate the effects of dietary acidolysis-oxidized konjac glucomannan (A-OKGM) (0%, 0.4%, 0.8%, and 1.6%) supplementation on the immunity and expression of immune-related genes in Schizothorax prenanti. After feeding for eight weeks, the serum and guts were used for measurement of biochemical parameters, and immune-related gene expression in the gut were also analyzed by real-time quantitative polymerase chain reaction (RT-qPCR). C-reactive protein and IgM levels were significantly higher in the A-OKGM fed groups than in the control group, regardless of the dosage. The 0.4% and 1.6% A-OKGM groups showed significant up-regulation of tumor necrosis factor α (TNFα) in the anterior gut. The 0.8% and 1.6% A-OKGM groups also showed significantly enhanced TNFα expression in the mid- and distal guts. Interleukin-1β (IL-1β) expression in the anterior gut of fish fed with 0.4% and 1.6% A-OKGM diets was significantly enhanced. The 0.8% and 1.6% A-OKGM diets resulted in significantly increased the expression of IL-1β in the distal gut. Similarly, the interleukin-6 (IL-6) messenger RNA (mRNA) levels in the 0.4% and 1.6% diet groups were significantly higher in the anterior gut. The 0.8% and 1.6% A-OKGM diet groups showed significant induction of IL-6 gene expression in the distal gut. A-OKGM modified from KGM can act as an immunostimulant to enhance the immunity of S. prenanti.
Estrogen Metabolism-Associated CYP2D6 and IL6-174G/C Polymorphisms in Schistosoma haematobium Infection
Authors: Cardoso Rita , Lacerda Pedro , Costa Paulo , Machado Ana , Carvalho André , Bordalo Adriano , Fernandes Ruben , Soares Raquel , Richter Joachim , Alves Helena , Botelho Monica
Published: November 2017

Schistosoma haematobium is a human blood fluke causing a chronic infection called urogenital schistosomiasis. Squamous cell carcinoma of the urinary bladder (SCC) constitutes chronic sequelae of this infection, and S. haematobium infection is accounted as a risk factor for this type of cancer. This infection is considered a neglected tropical disease and is endemic in numerous countries in Africa and the Middle East. Schistosome eggs produce catechol-estrogens. These estrogenic molecules are metabolized to active quinones that induce modifications in DNA. The cytochrome P450 (CYP) enzymes are a superfamily of mono-oxygenases involved in estrogen biosynthesis and metabolism, the generation of DNA damaging procarcinogens, and the response to anti-estrogen therapies. IL6 Interleukin-6 (IL-6) is a pleiotropic cytokine expressed in various tissues. This cytokine is largely expressed in the female urogenital tract as well as reproductive organs. Very high or very low levels of IL-6 are associated with estrogen metabolism imbalance. In the present study, we investigated the polymorphic variants in the CYP2D6 gene and the C-174G promoter polymorphism of the IL-6 gene on S. haematobium-infected children patients from Guine Bissau. CYP2D6 inactivated alleles (28.5%) and IL6G-174C (13.3%) variants were frequent in S. haematobium-infected patients when compared to previously studied healthy populations (4.5% and 0.05%, respectively). Here we discuss our recent findings on these polymorphisms and whether they can be predictive markers of schistosome infection and/or represent potential biomarkers for urogenital schistosomiasis associated bladder cancer and infertility.
The Hedgehog Signaling Pathway Emerges as a Pathogenic Target
Authors: Smelkinson Margery
Published: November 2017

The Hedgehog (Hh) signaling pathway plays an essential role in the growth, development, and homeostatis of many tissues in vertebrates and invertebrates. Much of what is known about Hh signaling is in the context of embryonic development and tumor formation. However, a growing body of evidence is emerging indicating that Hh signaling is also involved in postnatal processes such as tissue repair and adult immune responses. To that extent, Hh signaling has also been shown to be a target for some pathogens that presumably utilize the pathway to control the local infected environment. In this review, we discuss what is currently known regarding pathogenic interactions with Hh signaling and speculate on the reasons for this pathway being a target. We also hope to shed light on the possibility of using small molecule modulators of Hh signaling as effective therapies for a wider range of human diseases beyond their current use in a limited number of cancers.
Alcohol Interactions with Lipid Bilayers
Authors: Kondela Tomáš , Gallová Jana , Hauß Thomas , Barnoud Jonathan , Marrink Siewert-J. , Kučerka Norbert
Published: November 2017

We investigate the structural changes to lipid membrane that ensue from the addition of aliphatic alcohols with various alkyl tail lengths. Small angle neutron diffraction from flat lipid bilayers that are hydrated through water vapor has been employed to eliminate possible artefacts of the membrane curvature and the alcohol’s membrane-water partitioning. We have observed clear changes to membrane structure in both transversal and lateral directions. Most importantly, our results suggest the alteration of the membrane-water interface. The water encroachment has shifted in the way that alcohol loaded bilayers absorbed more water molecules when compared to the neat lipid bilayers. The experimental results have been corroborated by molecular dynamics simulations to reveal further details. Namely, the order parameter profiles have been fruitful in correlating the mechanical model of structural changes to the effect of anesthesia.
Contribution of Dietary Supplements to Nutritional Adequacy in Race/Ethnic Population Subgroups in the United States
Authors: Blumberg Jeffrey , Frei Balz , Fulgoni III Victor , Weaver Connie , Zeisel Steven
Published: November 2017

The U.S. Centers for Disease Control and Prevention has reported that nutritional deficiencies in the U.S. population vary by age, gender, and race/ethnicity, and could be as high as nearly one third of certain population groups. Based on nationally representative data in 10,698 adults from National Health and Nutrition Examination Surveys (NHANES) primarily from 2009–2012, assessments were made of race/ethnic differences in the impact of dietary supplements on nutrient intake and prevalence of inadequacies. Compared to food alone, use of any dietary supplement plus food was associated with significantly higher intakes of 14 to 16 of 19 nutrients examined in all race/ethnic groups; and significantly (p < 0.01) reduced rates of inadequacy for 8/17 nutrients examined in non-Hispanic whites, but only 3–4/17 nutrients (calcium, and vitamins A, D, and E) for other race/ethnic groups. Across race/ethnic groups an increased prevalence of intakes above the Tolerable Upper Intake Level (UL) was seen for 1–9/13 nutrients, but all were less than 5% of the population. In conclusion, use of dietary supplements is associated with increased micronutrient intake, decreased nutrient inadequacies, and slight increases in prevalence above the UL in all race/ethnicities examined, with greater benefits among non-Hispanic whites.
Dietary Sialyllactose Influences Sialic Acid Concentrations in the Prefrontal Cortex and Magnetic Resonance Imaging Measures in Corpus Callosum of Young Pigs
Authors: Mudd Austin , Fleming Stephen , Labhart Beau , Chichlowski Maciej , Berg Brian , Donovan Sharon , Dilger Ryan
Published: November 2017

Sialic acid (SA) is a key component of gangliosides and neural cell adhesion molecules important during neurodevelopment. Human milk contains SA in the form of sialyllactose (SL) an abundant oligosaccharide. To better understand the potential role of dietary SL on neurodevelopment, the effects of varying doses of dietary SL on brain SA content and neuroimaging markers of development were assessed in a newborn piglet model. Thirty-eight male pigs were provided one of four experimental diets from 2 to 32 days of age. Diets were formulated to contain: 0 mg SL/L (CON), 130 mg SL/L (LOW), 380 mg SL/L (MOD) or 760 mg SL/L (HIGH). At 32 or 33 days of age, all pigs were subjected to magnetic resonance imaging (MRI) to assess brain development. After MRI, pig serum and brains were collected and total, free and bound SA was analyzed. Results from this study indicate dietary SL influenced (p = 0.05) bound SA in the prefrontal cortex and the ratio of free SA to bound SA in the hippocampus (p = 0.04). Diffusion tensor imaging indicated treatment effects in mean (p < 0.01), axial (p < 0.01) and radial (p = 0.01) diffusivity in the corpus callosum. Tract-based spatial statistics (TBSS) indicated differences (p < 0.05) in white matter tracts and voxel-based morphometry (VBM) indicated differences (p < 0.05) in grey matter between LOW and MOD pigs. CONT and HIGH pigs were not included in the TBSS and VBM assessments. These findings suggest the corpus callosum, prefrontal cortex and hippocampus may be differentially sensitive to dietary SL supplementation.
Synthesis and Characterization of Dimmer-Acid-Based Nonisocyanate Polyurethane and Epoxy Resin Composite
Authors: He Xin , Xu Xiaoling , Wan Qian , Bo Guangxu , Yan Yunjun
Published: November 2017

In this study, dimmer-acid-based hybrid nonisocyanate polyurethanes (HNIPUs) were synthesized by the one-step method without catalyst. Three polyamines and two epoxy resins were selected as raw materials for HNIPU, and cyclic carbonate was synthesized based on our previous work. All of the products were characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and dynamic mechanical analysis (DMA). Then, HNIPU coatings were prepared and determined by swelling, water absorption, and water contact angle. The results showed that the HNIPU-4551 have the best mechanical and thermal properties because of its high crosslinking density. Among the different amines, it was confirmed that tetraethylenepentamine was the best amine curing agent for HNIPU coating. Meanwhile, the epoxy resin with a higher epoxy value would also form a higher crosslinking density. Those coatings showed an excellent impact strength, adhesion, flexibility, pencil hardness, hydrophilic, and appropriate crosslinking density.
The Multi-Template Molecularly Imprinted Polymer Based on SBA-15 for Selective Separation and Determination of Panax notoginseng Saponins Simultaneously in Biological Samples
Authors: Sun Chenghong , Wang Jinhua , Huang Jiaojiao , Yao Dandan , Wang Chong-Zhi , Zhang Lei , Hou Shuying , Chen Lina , Yuan Chun-Su
Published: November 2017

The feasible, reliable and selective multi-template molecularly imprinted polymers (MT-MIPs) based on SBA-15 (SBA-15@MT-MIPs) for the selective separation and determination of the trace level of ginsenoside Rb1 (Rb1), ginsenoside Rg1 (Rg1) and notoginsenoside R1 (R1) simultaneously from biological samples were developed. The polymers were constructed by SBA-15 as support, Rb1, Rg1, R1 as multi-template, acrylamide (AM) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker. The new synthetic SBA-15@MT-MIPs were satisfactorily applied to solid-phase extraction (SPE) coupled with high performance liquid chromatography (HPLC) for the separation and determination of trace Rb1, Rg1 and R1 in plasma samples. Under the optimized conditions, the limits of detection (LODs) and quantitation (LOQs) of the proposed method for Rb1, Rg1 and R1 were in the range of 0.63–0.75 ng·mL−1 and 2.1–2.5 ng·mL−1, respectively. The recoveries of R1, Rb1 and Rg1 were obtained between 93.4% and 104.3% with relative standard deviations (RSDs) in the range of 3.3–4.2%. All results show that the obtained SBA-15@MT-MIPs could be a promising prospect for the practical application in the selective separation and enrichment of trace Panax notoginseng saponins (PNS) in the biological samples.
Spirituality in the Healthcare Workplace
Authors: Baldacchino Donia
Published: November 2017

Spirituality involves a sense of connectedness, meaning making and transcendence. There is abundant published research that focuses on the importance of spirituality to patients and their families during times of illness and distress. However over the last decade there has also been a growing awareness about the importance of considering the need to address peoples’ spiritual needs in the workplace. Engaging in ones own personal spirituality involves connecting with the inner self, becoming more self aware of ones humanity and limitations. Engaging with ones personal spirituality can also mean that people begin to greater find meaning and purpose in life and at work. This may be demonstrated in the workplace by collegial relationships and teamwork. Those who engage with their own spirituality also engage more easily with others through a connectedness with other staff and by aligning their values with the respective organization if they fit well with ones personal values. Workplace spirituality is oriented towards self-awareness of an inner life which gives meaning, purpose and nourishment to the employees’ dynamic relationships at the workplace and is eventually also nourished by meaningful work. Exercising ones personal spirituality contributes towards generating workplace spirituality. Essentially acting from ones own personal spirituality framework by being in doing can contribute towards a person becoming a healing and therapeutic presence for others, that is nourishing in many workplaces. Personal spirituality in healthcare can be enhanced by: reflection in and on action; role-modeling; taking initiative for active presence in care; committing oneself to the spiritual dimension of care; and, integrating spirituality in health caregivers’ education. As spirituality is recognized as becoming increasingly important for patients in healthcare, increasing educational opportunities are now becoming available for nurses internationally that could support personal and workplace spirituality.
TCCON Philippines: First Measurement Results, Satellite Data and Model Comparisons in Southeast Asia
Authors: Velazco Voltaire , Morino Isamu , Uchino Osamu , Hori Akihiro , Kiel Matthäus , Bukosa Beata , Deutscher Nicholas , Sakai Tetsu , Nagai Tomohiro , Bagtasa Gerry , Izumi Toshiharu , Yoshida Yukio , Griffith David
Published: November 2017

The Total Carbon Column Observing Network (TCCON) is a global network dedicated to the precise and accurate measurements of greenhouse gases (GHG) in the atmosphere. The TCCON station in Burgos, Ilocos Norte, Philippines was established with the primary purpose of validating the upcoming Greenhouse gases Observing SATellite-2 (GOSAT-2) mission and in general, to respond to the need for reliable ground-based validation data for satellite GHG observations in the region. Here, we present the first 4 months of data from the new TCCON site in Burgos, initial comparisons with satellite measurements of C O 2 and model simulations of C O . A nearest sounding from Japan’s GOSAT as well as target mode observations from NASA’s Orbiting Carbon Observatory 2 (OCO-2) showed very good consistency in the retrieved column-averaged dry air mole fractions of C O 2 , yielding TCCON - satellite differences of 0.86 ± 1.06 ppm for GOSAT and 0.83 ± 1.22 ppm for OCO-2. We also show measurements of enhanced C O , probably from East Asia. GEOS-Chem model simulations were used to study the observed C O variability. However, despite the model capturing the pattern of the C O variability, there is an obvious underestimation in the C O magnitude in the model. We conclude that more measurements and modeling are necessary to adequately sample the variability over different seasons and to determine the suitability of current inventories.
Using Copernicus Atmosphere Monitoring Service Products to Constrain the Aerosol Type in the Atmospheric Correction Processor MAJA
Authors: Rouquié Bastien , Hagolle Olivier , Bréon François-Marie , Boucher Olivier , Desjardins Camille , Rémy Samuel
Published: November 2017

The quantitative use of space-based optical imagery requires atmospheric correction to separate the contributions from the surface and the atmosphere. The MACCS (Multi-sensor Atmospheric Correction and Cloud Screening)-ATCOR (Atmospheric and Topographic Correction) Joint Algorithm, called MAJA, is a numerical tool designed to perform cloud detection and atmospheric correction. For the correction of aerosols effects, MAJA makes an estimate of the aerosol optical thickness (AOT) based on multi-temporal and multi-spectral criteria, but there is insufficient information to infer the aerosol type. The current operational version of MAJA uses an aerosol type which is constant with time, and this assumption impacts the quality of the atmospheric correction. In this study, we assess the potential of using an aerosol type derived from the Copernicus Atmosphere Monitoring Service (CAMS) operational analysis. The performances, with and without the CAMS information, are evaluated. Firstly, in terms of the aerosol optical thickness retrievals, a comparison against sunphotometer measurements over several sites indicates an improvement over arid sites, with a root-mean-square error (RMSE) reduced by 28% (from 0.095 to 0.068), although there is a slight degradation over vegetated sites (RMSE increased by 13%, from 0.054 to 0.061). Secondly, a direct validation of the retrieved surface reflectances at the La Crau station (France) indicates a reduction of the relative bias by 2.5% on average over the spectral bands. Thirdly, based on the assumption that surface reflectances vary slowly with time, a noise criterion was set up, exhibiting no improvement over the spectral bands and the validation sites when using CAMS data, partly explained by a slight increase in the surface reflectances themselves. Finally, the new method presented in this study provides a better way of using the MAJA processor in an operational environment because the aerosol type used for the correction is automatically inferred from CAMS data, and is no longer a parameter to be defined in advance.
Effect of Composition and Thickness on the Perpendicular Magnetic Anisotropy of (Co/Pd) Multilayers
Authors: Tudu Bharati , Tian Kun , Tiwari Ashutosh
Published: November 2017

Magnetic materials with perpendicular magnetic anisotropy (PMA) have wide-ranging applications in magnetic recording and sensing devices. Multilayers comprised of ferromagnetic and non-magnetic metals (FM–NM) are interesting materials, as their magnetic anisotropy depends strongly on composition and growth parameters. In this context, (Co/Pd) multilayers have gained huge interest recently due to their robustness and tunable PMA. Here, we report a systematic study of the effect of composition on the magnetic anisotropy of (Co/Pd) multilayers grown by Direct Current (DC) magnetron sputtering. Four different series of (Co/Pd)×10 multilayers with different thicknesses of Co and Pd were examined. Vibrating sample magnetometery was used to determine the magnetic anisotropy of these films. X-ray diffraction and transmission electron microscopy experiments were performed to understand the structural morphology of the films. Our results showed that (Co/Pd)×10 multilayers exhibit PMA when the Co to Pd ratio is less than or equal to 1 and the thickness of Co layers is not more than 5 Å. Maximum effective anisotropy energy is shown by the films with a Co to Pd ratio of 1/3.
Development of a High Precision Displacement Measurement System by Fusing a Low Cost RTK-GPS Sensor and a Force Feedback Accelerometer for Infrastructure Monitoring
Authors: Koo Gunhee , Kim Kiyoung , Chung Jun , Choi Jaemook , Kwon Nam-Yeol , Kang Doo-Young , Sohn Hoon
Published: November 2017

A displacement measurement system fusing a low cost real-time kinematic global positioning system (RTK-GPS) receiver and a force feedback accelerometer is proposed for infrastructure monitoring. The proposed system is composed of a sensor module, a base module and a computation module. The sensor module consists of a RTK-GPS rover and a force feedback accelerometer, and is installed on a target structure like conventional RTK-GPS sensors. The base module is placed on a rigid ground away from the target structure similar to conventional RTK-GPS bases, and transmits observation messages to the sensor module. Then, the initial acceleration, velocity and displacement responses measured by the sensor module are transmitted to the computation module located at a central monitoring facility. Finally, high precision and high sampling rate displacement, velocity, and acceleration are estimated by fusing the acceleration from the accelerometer, the velocity from the GPS rover, and the displacement from RTK-GPS. Note that the proposed displacement measurement system can measure 3-axis acceleration, velocity as well as displacement in real time. In terms of displacement, the proposed measurement system can estimate dynamic and pseudo-static displacement with a root-mean-square error of 2 mm and a sampling rate of up to 100 Hz. The performance of the proposed system is validated under sinusoidal, random and steady-state vibrations. Field tests were performed on the Yeongjong Grand Bridge and Yi Sun-sin Bridge in Korea, and the Xihoumen Bridge in China to compare the performance of the proposed system with a commercial RTK-GPS sensor and other data fusion techniques.
Mathematical Model for Localised and Surface Heat Flux of the Human Body Obtained from Measurements Performed with a Calorimetry Minisensor
Authors: Socorro Fabiola , Rodríguez de Rivera Pedro , Rodríguez de Rivera Miriam , Rodríguez de Rivera Manuel
Published: November 2017

The accuracy of the direct and local measurements of the heat power dissipated by the surface of the human body, using a calorimetry minisensor, is directly related to the calibration rigor of the sensor and the correct interpretation of the experimental results. For this, it is necessary to know the characteristics of the body’s local heat dissipation. When the sensor is placed on the surface of the human body, the body reacts until a steady state is reached. We propose a mathematical model that represents the rate of heat flow at a given location on the surface of a human body by the sum of a series of exponentials: W(t) = A0 + ∑Aiexp(−t/τi). In this way, transient and steady states of heat dissipation can be interpreted. This hypothesis has been tested by simulating the operation of the sensor. At the steady state, the power detected in the measurement area (4 cm2) varies depending on the sensor’s thermostat temperature, as well as the physical state of the subject. For instance, for a thermostat temperature of 24 °C, this power can vary between 100–250 mW in a healthy adult. In the transient state, two exponentials are sufficient to represent this dissipation, with 3 and 70 s being the mean values of its time constants.
The Functional Structure Convergence of China’s Coastal Ports
Authors: Wang Wei , Wang Chengjin , Jin Fengjun
Published: November 2017

Functional structure is an important part of a port system, and can reflect the resource endowments and economic development needs of the hinterland. In this study, we investigated the transportation function of coastal ports in China from the perspective of cargo structure using a similarity coefficient. Our research considered both adjacent ports and hub ports. We found that the transportation function of some adjacent ports was very similar in terms of outbound structure (e.g., Qinhuangdao and Huanghua) and inbound structure (e.g., Huanghua and Tangshan). Ports around Bohai Bay and the port group in the Yangtze River Delta were the most competitive areas in terms of outbound and inbound structure, respectively. The major contributors to port similarity in different regions varied geographically due to the different market demands and cargo supplies. For adjacent ports, the functional convergence of inbound structure was more serious than the outbound. The convergence between hub ports was more serious than between adjacent ports in terms of both outbound and inbound structure. The average similarity coefficients displayed an increasing trend over time. This study further develops the theory of transport geography, improves our understanding of China’s port transportation system, and can provide reference for policy-makers in their port development decisions.
Using Synergy between Water Limnology and Satellite Imagery to Identify Algal Blooms Extent in a Brazilian Amazonian Reservoir
Authors: De Sousa Brandão Isabel , Mannaerts Chris , Verhoef Wouter , Saraiva Augusto , Paiva Rosildo , Da Silva Elidiane
Published: November 2017

Monitoring algal blooms from space is a very challenging task, which becomes particularly difficult when dealing with cyanobacteria blooms. Cyanobacteria are strategic organisms adapted to a wide variety of environmental conditions. In high concentrations, they form scum on the water surface, which is a concern for public health due to the production of toxins, as well as being a nuisance. Knowledge of the ecological role of these organisms is, therefore, essential when trying to estimate their extent from satellite-based data. We present a multidisciplinary approach, based on both the ecological and the optical perspective. This approach is applied in a Brazilian Amazonian reservoir using spatial and temporal scales. The ACOLITE processor is employed to perform atmospheric correction. Extent of the algal bloom is mapped with outputs such as Rayleigh reflectance atmospheric corrected images. Chlorophyll-a estimation is accomplished using a blue-green edge algorithm from the Ocean Biology Processing Group (OBPG), and shows reasonable results (R2 = 0.95; RMSE = 0.40). The SAred-NIR slope algorithm identifies the extent of the algal bloom at both the spatial and temporal scale. Unfortunately, the performance of these algorithms is most likely affected by weather conditions and glint effects. Therefore, this study recommends that cyanobacteria or phytoplankton studies in this area ensure that their ecological functioning is carefully considered when attempting to map occurrence using limited satellite imagery.
Trade-Offs in Multi-Purpose Land Use under Land Degradation
Authors: Vlek Paul , Khamzina Asia , Azadi Hossein , Bhaduri Anik , Bharati Luna , Braimoh Ademola , Martius Christopher , Sunderland Terry , Taheri Fatemeh
Published: November 2017

Land provides a host of ecosystem services, of which the provisioning services are often considered paramount. As the demand for agricultural products multiplies, other ecosystem services are being degraded or lost entirely. Finding a sustainable trade-off between food production and one or more of other ecosystem services, given the variety of stakeholders, is a matter of optimizing land use in a dynamic and complex socio-ecological system. Land degradation reduces our options to meet both food demands and environmental needs. In order to illustrate this trade-off dilemma, four representative services, carbon sinks, water storage, biodiversity, and space for urbanization, are discussed here based on a review of contemporary literature that cuts across the domain of ecosystem services that are provided by land. Agricultural research will have to expand its focus from the field to the landscape level and in the process examine the cost of production that internalizes environmental costs. In some situations, the public cost of agriculture in marginal environments outweighs the private gains, even with the best technologies in place. Land use and city planners will increasingly have to address the cost of occupying productive agricultural land or the conversion of natural habitats. Landscape designs and urban planning should aim for the preservation of agricultural land and the integrated management of land resources by closing water and nutrient cycles, and by restoring biodiversity.
Are We Underestimating Benthic Cyanotoxins? Extensive Sampling Results from Spain
Authors: Cantoral Uriza Enrique , Asencio Antonia , Aboal Marina
Published: November 2017

Microcystins (MCs) are potent hepatotoxins, and their presence in water bodies poses a threat to wildlife and human populations. Most of the available information refers to plankton, and much less is known about microcystins in other habitats. To broaden our understanding of the presence and environmental distribution of this group of toxins, we conducted extensive sampling throughout Spain, under a range of conditions and in distinct aquatic and terrestrial habitats. More than half of the tested strains were toxic; concentrations of the hepatotoxin were low compared with planktic communities, and the number of toxic variants identified in each sample of the Spanish strains ranged from 1–3. The presence of microcystins LF and LY (MC-LF and MC-LY) in the tested samples was significant, and ranged from 21.4% to 100% of the total microcystins per strain. These strains were only detected in cyanobacteria Oscillatoriales and Nostocales. We can report, for the first time, seven new species of microcystin producers in high mountain rivers and chasmoendolithic communities. This is the first report of these species in Geitlerinema and the confirmation of Anatoxin-a in Phormidium uncinatum. Our findings show that microcystins are widespread in all habitat types, including both aerophytic and endolithic peat bogs and that it is necessary to identify all the variants of microcystins in aquatic bodies as the commonest toxins sometimes represent a very low proportion of the total.
Simulating Flash Floods at Hourly Time-Step Using the SWAT Model
Authors: Boithias Laurie , Sauvage Sabine , Lenica Anneli , Roux Hélène , Abbaspour Karim , Larnier Kévin , Dartus Denis , Sánchez-Pérez José
Published: November 2017

Flash floods are natural phenomena with environmental, social and economic impacts. To date, few numerical models are able to simulate hydrological processes at catchment scale at a reasonable time scale to describe flash events with accurate details. Considering a ~810 km2 Mediterranean river coastal basin (southwestern France) as a study case, the objective of the present study was to assess the ability of the sub-daily module of the lumped Soil and Water Assessment Tool (SWAT) to simulate discharge (1) time-continuously, by testing two sub-basin delineation schemes, two catchment sizes, and two output time-steps; and (2) at flood time-scale, by comparing the performances of SWAT to the performances of the event-based fully distributed MARINE model when simulating flash flood events. We showed that there was no benefit of decreasing the size of the minimum drainage area (e.g., from ~15 km2 down to ~1 km2) when delineating sub-basins in SWAT. We also showed that both the MARINE and SWAT models were equally able to reproduce peak discharge, flood timing and volume, and that they were both limited by rainfall and soil data. Hence, the SWAT model appears to be a reliable modelling tool to predict discharge over long periods of time in large flash-flood-prone basins.
Pyrene–nucleobase conjugates: synthesis, oligonucleotide binding and confocal bioimaging studies
Authors: Jabłoński Artur , Fritz Yannic , Wagenknecht Hans-Achim , Czerwieniec Rafał , Bernaś Tytus , Trzybiński Damian , Woźniak Krzysztof , Kowalski Konrad
Published: November 2017

Fluorescent pyrene–linker–nucleobase (nucleobase = thymine, adenine) conjugates with carbonyl and hydroxy functionalities in the linker were synthesized and characterized. X-ray single-crystal structure analysis performed for the pyrene–C(O)CH2CH2–thymine (2) conjugate reveals dimers of molecules 2 stabilized by hydrogen bonds between the thymine moieties. The photochemical characterization showed structure-dependent fluorescence properties of the investigated compounds. The conjugates bearing a carbonyl function represent weak emitters as compared to compounds with a hydroxy function in the linker. The self-assembly properties of pyrene nucleobases were investigated in respect to their binding to single and double strand oligonucleotides in water and in buffer solution. In respect to the complementary oligothymidine T10 template in water, compounds 3 and 5 both show a self-assembling behavior according to canonical base–base pairing. However, in buffer solution, derivative 5 was much more effective than 3 in binding to the T10 template. Furthermore the adenine derivative 5 binds to the double-stranded (dA)10–T10 template with a self-assembly ratio of 112%. Such a high value of a self-assembly ratio can be rationalized by a triple-helix-like binding, intercalation, or a mixture of both. Remarkably, compound 5 also shows dual staining pattern in living HeLa cells. Confocal microscopy confirmed that 5 predominantly stains mitochondria but it also accumulates in the nucleoli of the cells.
The Global Color of Pluto from New Horizons
Authors: Olkin Catherine B. , Spencer John R. , Grundy William M. , Parker Alex H. , Beyer Ross A. , Schenk Paul M. , Howett Carly J. A. , Stern S. Alan , Reuter Dennis C. , Weaver Harold A. , Young Leslie A. , Ennico Kimberly , Binzel Richard P. , Buie Marc W. , Cook Jason C. , Cruikshank Dale P. , Ore Cristina M. Dalle , Earle Alissa M. , Jennings Donald E. , Singer Kelsi N. , Linscott Ivan E. , Lunsford Allen W. , Protopapa Silvia , Schmitt Bernard , Weigle Eddie ,   and the New Horizons Science Team
Published: November 2017

The New Horizons flyby provided the first high-resolution color maps of Pluto. We present here, for the first time, an analysis of the color of the entire sunlit surface of Pluto and the first quantitative analysis of color and elevation on the encounter hemisphere. These maps show the color variation across the surface from the very red terrain in the equatorial region, to the more neutral colors of the volatile ices in Sputnik Planitia, the blue terrain of East Tombaugh Regio, and the yellow hue on Pluto’s North Pole. There are two distinct color mixing lines in the color–color diagrams derived from images of Pluto. Both mixing lines have an apparent starting point in common: the relatively neutral-color volatile-ice covered terrain. One line extends to the dark red terrain exemplified by Cthulhu Regio and the other extends to the yellow hue in the northern latitudes. There is a latitudinal dependence of the predominant color mixing line with the most red terrain located near the equator, less red distributed at mid-latitudes and more neutral terrain at the North Pole. This is consistent with the seasonal cycle controlling the distribution of colors on Pluto. Additionally, the red color is consistent with tholins. The yellow terrain (in the false color images) located at the northern latitudes occurs at higher elevations.
A Note on the Spin–Orbit, Spin–Spin, and Spin–Orbit–Spin Resonances in the Binary Minor Planet System
Authors: Hou Xiyun , Xin Xiaosheng
Published: November 2017

By considering a varying mutual orbit between the two bodies in a binary minor planet system, modified models for the spin–orbit, spin–spin, and spin–orbit–spin resonances are given. For the spin–orbit resonances, our study shows that the resonance center changes with the mass ratio and the mutual distance between the two bodies, and the size of the body in the resonance. The 1:1, 3:2, and 1:2 resonances are taken as examples to show the results. For the spin–spin and spin–orbit–spin resonances, our studies show that the resonance center changes with the rotation states of the two minor planets. The 1:1 spin–spin resonance and the 1:2:1 spin–orbit–spin resonance are discussed in detail. Simple analytical criteria are given to identify the resonance centers, and numerical simulations were ran in order to verify the analytical results.
Discovery of the New X-Ray Transient MAXI J1807+132: A Candidate of a Neutron Star Low-mass X-Ray Binary
Authors: Shidatsu Megumi , Tachibana Yutaro , Yoshii Taketoshi , Negoro Hitoshi , Kawamuro Taiki , Iwakiri Wataru , Nakahira Satoshi , Makishima Kazuo , Ueda Yoshihiro , Kawai Nobuyuki , Serino Motoko , Kennea Jamie
Published: November 2017

We report on the detection and follow-up multi-wavelength observations of the new X-ray transient MAXI J1807+132 with the MAXI/GSC, Swift, and ground-based optical telescopes. The source was first recognized with the MAXI/GSC on 2017 March 13. About a week later, it reached maximum intensity (∼10 mCrab in 2–10 keV), and then gradually faded in ∼10 days by more than one order of magnitude. Time-averaged Swift/X-ray Telescope spectra in the decaying phase can be described by a blackbody with a relatively low temperature (0.1–0.5 keV), plus a hard power-law component with a photon index of ∼2. These spectral properties are similar to those of neutron star low-mass X-ray binaries (LMXBs) in their dim periods. The blackbody temperature and the radius of the emission region varied in a complex manner as the source became dimmer. The source was detected in the optical wavelength on March 27–31 as well. The optical flux decreased monotonically as the X-ray flux decayed. The correlation between the X-ray and optical fluxes is found to be consistent with those of known neutron star LMXBs, supporting the idea that the source is likely to be a transient neutron star LMXB.
The Detection of 6.9 μm Emission Features in the Infrared Spectra of IRAS 04296+3429, IRAS 05341+0852, and IRAS 22272+5435: Evidence for the Presence of Hn-PAHs in Post-AGB Stars
Authors: Materese Christopher K. , Bregman Jesse D. , Sandford Scott A.
Published: November 2017

Polycyclic aromatic hydrocarbons (PAHs) are generally believed to be ubiquitous in space and responsible for numerous telltale interstellar infrared emission bands. In Sandford et al., we suggested that PAHs with excess hydrogenation at their periphery (

-PAHs) may be an important subclass of these molecules in some astrophysical environments. These molecules are candidates to explain objects with anomalously large 3.4 μm features, which are presumed to be associated with the aliphatic C–H stretching vibrations of the excess hydrogen. In that work, we suggest that for Hn-PAHs to be a viable candidate as the source for this 3.4 μm feature, we must also expect to observe methylene scissoring modes at 6.9 μm. In this work, we continue to develop the

hypothesis with a focus on the 6.9 μm feature. We also present some new observations of three post-asymptotic giant branch (post-AGB) objects with abnormally large 3.4 μm features, IRAS 04296+3429, IRAS 05341+0852, and IRAS 22272+5435, in addition to one post-AGB object with normal PAH emissions, IRAS 20000+3239. These observations were made using the FORCAST instrument in grism mode on the Stratospheric Observatory for Infrared Astronomy aircraft and demonstrate the presence of a 6.9 μm feature for the three objects with abnormally large 3.4 μm features and no detectable 6.9 μm feature for the normal PAH emitter. These results are consistent with the hypothesis that Hn-PAHs are a possible source of these infrared emission bands.
Addictions, développement précoce et stratégies de holding
Authors: réseau DAPSA Équipe du
Published: November 2017

Nous présentons un dispositif et une proposition de travail qui visent à constituer un groupe soignant prévenant autour des familles pour lesquelles les problématiques addictives des parents peuvent faire craindre des difficultés pour le développement précoce de l’enfant. Ce travail exige de prendre en compte les représentations des personnes concernées, aussi bien patients que professionnels, afin de repérer les freins à l’accès aux soins, mais aussi les pistes rendant le soin acceptable. Si l’objectif déclaré est de permettre au parent de devenir aidant de son enfant, cette aide peut en revanche prendre des formes diverses.
Atelier Nesting
Authors: Dubos Delphine , de Barbot Françoise , Frischmann Martine
Published: November 2017

Les ateliers Nesting, mis en place par la clinique Belledonne, entre autres, ont pour objectif de sensibiliser les futurs parents à l’exposition à une multitude de polluants dans notre environnement quotidien. Leur but est de les aider à préparer un environnement sain autour de la venue du bébé par la réduction de cette exposition.