bluuebunny/crossref_metadata_2025 huggingface dataset:
Uso de acetato de abiraterona en pacientes con cáncer de próstata metastásico resistente a la castración, vírgenes a quimioterapia. Experiencia de la vida real en un Centro Médico de la Ciudad de México
Authors: Alias-Melgar Alejandro , Cortéz-Betancourt Roberto , Suárez-Cuenca Juan Antonio , Ramírez-Garduño Emilio , Ordoñez-Campos Eduardo , Carreño-De la Rosa Fernando , Botello-Gómez Pedro , Camargo-Altamirano Leonardo , Sierra-Sosa José Gerardo , González-Serrano Adolfo , Trujillo-Vázquez Eric Iván , Pérez-Cabeza de Vaca Rebeca , Pineda-Juárez Juan Antonio , Mondragón-Terán Paul , Erazo-Valle Solís Aura Argentina
Published: December 2020

Objetivo: Analizar la experiencia clínica con el acetato de abiraterona en pacientes con cáncer de próstata metastásico resistente a la castración (mCRPC, por sus siglas en inglés) vírgenes a quimioterapia, en un escenario de la vida real en un Centro Médico de la Ciudad de México.

Métodos. Estudio observacional en pacientes del Departamento de Urología, CMN "20 de Noviembre", ISSSTE; con mCRPC vírgenes a quimioterapia. Se administraron acetato de abiraterona más prednisona y leuprolida durante Enero de 2014 a Diciembre de 2016. Evaluación primaria: tiempo hasta la progresión radiológica y sobrevida. Evaluación secundaria (tiempo para progresión de ECOG, tiempo para inicio de quimioterapia citotóxica, tiempo para uso de analgésicos y tiempo para progresión del APE), en subgrupos divididos por el puntaje de Gleason.

Resultados. Dieciocho pacientes recibieron acetato de abiraterona. La progresión radiográfica se observó después de 7 y 10 meses (2 casos, 11.1%); y la muerte (1 caso, 5,5%) ocurrió después de 9 meses. El uso temprano de analgésicos fue frecuente (>50% a los 10 meses); mientras que la progresión de la enfermedad, reflejada por el inicio de la quimioterapia, la elevación del puntaje de ECOG y valores de APE, ocurrió en <50%. Además, observamos una tendencia a un inicio más temprano de la quimioterapia, la progresión de ECOG y el uso de analgésicos si el puntaje de Gleason era >7. Trece (72.2%) pacientes mostraron eventos adversos como fatiga, dolor de espalda, sofocos y otros; ninguno de ellos fue fatal.

Conclusión. El uso de acetato de abiraterona resultó tan eficaz y seguro en un escenario del mundo real en la muestra estudiada, como en los reportes previos de la literatura; por lo que puede ser una opción terapéutica valiosa en poblaciones similares.
Tumores de vejiga no uroteliales , como reto diagnóstico y terapéutico
Authors: Reyna-Blanco Irving , Jiménez-García Aldo , Martínez-Salas Alán De Jesús , Muruato-Araiza Jesús Sebastián , Herrerías-Ordoñez Andrea , Morales-Montor Gustavo , Martínez-Arroyo Carlos , Fernández-Noyola Gerardo , Cantellano-Orozco Mauricio , Pacheco-Gahbler Carlos
Published: December 2020

Introducción: El cáncer de vejiga se clasifica en general como urotelial y no urotelial. El no urotelial representa menos del 5% de todos los tumores vesicales y de estos el 90% son de origen epitelial, incluyendo: carcinoma de células escamosas, de células pequeñas y adenocarcinoma. El 10% restante es de origen no epitelial (linfoma, paranganglioma, sarcoma, etc.).

Objetivo: Presentar la experiencia del cáncer de vejiga no urotelial y describir las características de los pacientes en nuestra institución.

Materiales y métodos: Estudio retrospectivo y descriptivo de expedientes de pacientes con cáncer vesical no urotelial, diagnosticados y tratados en nuestro servicio de 2004 al 2016, obteniendo 7 casos.

Resultados: 7 pacientes, 5 hombres y 2 mujeres. Edad 53 años (35-76). Síntomas principales hematuria 4, STUI 2 y mucosuria 1 . Histopatología: adenocarcinoma 3, carcinoma epidermoide 2, paraganglioma 1 y linfoma 1. Localización mas frecuente: domo vesical. Tratamiento: Adenocarcinoma (3): Cistectomía parcial 2, solo rtuv 1. Carcinoma epidermoide (2): 1 nefroureterectomía izquierda + cistoprostatectomía radical, 1 cistectomía radical + exenteración pélvica, ambos casos con RT adyuvante; Paraganglioma: 1 Cistectomía parcial laparoscópica asistida por robot, Linfoma: 1 rtuv + Quimioterapia + radioterapia. 2 defunciones por carcinoma epidermoide.

Discusión: Dada la poca frecuencia de estos casos es difícil la estandarización entre el tratamiento y la histopatología, pero en general la cirugía es la mejor opción terapéutica para evitar la recurrencia y mejorar supervivencia, en algunos casos se recomiendan terapias conservadoras de órgano con terapias adyuvantes personalizadas a la histopatología.

Conclusiones: El manejo de los tumores vesicales no uroteliales es complejo y requiere de un equipo multidisciplinario. Los tumores mas agresivos son epidermoides con alta posibilidad de extensión locorregional. La experiencia en México es limitada.
Evaluation of cysteine-stabilised peptide fraction of aqueous extract of Morinda lucida leaf for hepatotoxic effects in mice
Authors: Adebayo J.O. , Adewole K. E.
Published: December 2020

Cysteine-stabilised peptide fraction of the aqueous extract of Morinda lucida leaf has been reported to exert diverse biological activities, but its effects on the liver have not been evaluated. This study was carried out to evaluate the effects of cysteine-stabilised peptide fraction (CSPF) of aqueous extract of Morinda lucida leaf on selected liver function indices in mice. Sixty mice were randomly divided into six groups of ten mice each. Mice in group A (control) were orally administered 5% DMSO while mice in groups B, C, D, E and F were orally administered 31.25, 62.5, 125, 250 and 500 mg/kg body weight of CSPF respectively. Half of the mice in the groups received the respective doses of CSPF for 7 days while the other half received them for 28 days, after which selected liver function indices in the serum and liver of the mice were determined. The results revealed that plasma alkaline phosphatase, gamma glutamyl transferase and glutamate dehydrogenase activities and plasma albumin, globulin, total bilirubin and conjugated bilirubin concentrations were not significantly (P>0.05) altered after 7 and 28 days of CSPF administration at all doses compared to controls. However, liver alanine aminotransferase (ALT) activity was significantly reduced (p<0.05) at doses of CSPF higher than 125 mg/kg body weight, with no corresponding alteration in serum ALT activity after 28 days of administration compared to controls. Thus, prolonged administration of high doses of CSPF may adversely affect the glucose-alanine cycle in the liver which is very important for glucose homeostasis during fasting.
The effect of morphine on the development rate of flies (Diptera: Calliphoridae, Sarcophagidae) reared on rabbit carcasses containing this drug and its implications to postmortem interval estimates
Authors:   Zoology Department, Faculty of Science, Alexandria University, Egypt, M. El-Samad Lamia , I. Tantawi Tarek ,   Zoology Department, Faculty of Science, Alexandria University, Egypt, A. El-Ghaffar Hedayat ,   Zoology Department, Faculty of Science, Alexandria University, Egypt, I. Beltagy Bassyony ,   Zoology Department, Faculty of Science, Alexandria University, Egypt, El-Abd Eman ,   Zoology Department, Faculty of Science, Alexandria University, Egypt
Published: December 2020

Insects can prove to be a valuable tool in the estimation of PMI in the investigation of homicides, suicides, and other unattended human deaths, in the absence of tissues and body fluids. Aim: The current study aimed to determine morphine concentration in the second, third feeding, third post-feeding instars, and puparial skin of four forensically important flies; Lucilia sericata (Meigen), Chrysomya albiceps (Wiedemann), Chrysomya megacephala (Fabricius) (Calliphoridae), and Sarcophaga argyrostoma (Robineau-Desvoidy) (Sarcophagidae) and to evaluate its effect on the rate and pattern of development of these flies. Materials and methods: Three female domestic rabbits, Oryctolagus cuniculus (L.) each weighing 2.5 kg received dosages of 7.5, 15, and 30 mg of morphine over a 3-h period via left ear artery perfusion. For each trial, one other rabbit, weighing 2.5 kg, was used as a control. Morphine was detected in larval instars and puparial skin using ready to use RIA kit. Results: All blood and tissue samples obtained from the rabbits receiving dosages of morphine were positive for the drug. Morphine concentrations for rabbit R2 were 1.2 to 2.6 times greater than those for rabbit R1, and concentrations for rabbit R3 were 1.4 to 3.1 times greater than those for rabbit R2. For each rabbit, morphine concentration in second, third feeding and third post-feeding instars, and puparial skin for all four species, were less than those detected in the tissues. The highest levels of morphine were recorded in the feeding third instars of Chr. megacephala R3 colony, whereas the lowest level of this drug was detected in the feeding third instars of S. argyrostoma R1 colony. Estimations of larval age for L. sericata, Chr. albiceps, Chr. megacephala and S. argyrostoma based on mean length can be significantly in error if presence of morphine in the tissues is not considered. This error can be as great as 24, 27, 6 and 21 h respectively. Conclusion: In cases of badly decomposed and/or skeletonized remains, analyses of collected carrion-feeding insects, may provide the most accurate qualitative sources of toxicological information.
Air–sea carbon flux from high-temporal-resolution data of in situ CO2 measurements in the southern North Sea
Authors: Pint Steven , Everaert Gert , Theetaert Hannelore , Vandegehuchte Michiel B. , Gkritzalis Thanos
Published: December 2020

Abstract. An important element to keep track of global change is the atmosphere–water exchange of carbon dioxide (CO2) in the ocean as it provides insight in how much CO2 is incorporated in the ocean (i.e. the ocean as a sink for CO2) or emitted to the atmosphere (i.e. the ocean as a source). To date, only few high-resolution observation sets are available to quantify the spatiotemporal variability of air–sea CO2 fluxes. In this study, we used observations of pCO2 collected daily at the ICOS station Thornton Buoy in the southern North Sea from February until December 2018 to calculate air–sea CO2 fluxes. Our results show a seasonal variability of the air–sea carbon flux, with the sea being a carbon sink from February until June switching to a carbon source in July and August, before switching back to a sink until December. We calculated that the sink was largest in April (−0.95 ± 0.90 mmol C m−2 d−1), while in August, the source was at its maximum (0.08 ± 0.13 mmol C m−2 d−1). On an annual basis, we found a sink for atmospheric CO2 of 130.19 ± 149.93 mmol C m−2 y−1. Apart from region- and basin-scale estimates of the air–sea CO2 flux, also local measurements are important to grasp local dynamics of the flux and its interactions with biogeochemical processes.
Microfossil assemblages and geochemistry for interpreting the incidence of the Jenkyns Event (early Toarcian) in the south-eastern Iberian Palaeomargin (External Subbetic, SE Spain)
Authors: Reolid Matías
Published: December 2020

Abstract. By studying the facies, geochemistry, and microfossil assemblages of the
uppermost Pliensbachian and lower Toarcian of the Cueva del Agua section, I
was able to appraise the impact of the Jenkyns Event in the eastern part of
the South Iberian Palaeomargin (Western Tethys). Depleted oxygen conditions
are envisaged for the Polymorphum–Serpentinum Zone boundary (lower
Toarcian), represented by dark marls, precisely in a laminated interval. The
decrease in the α diversity of foraminifera and ostracods, along
with greater proportions of opportunists such as Lenticulina, Eoguttulina, and Cytherella just before the
negative carbon isotopic excursion (CIE), would indicate a disturbance of the
environmental conditions during the initial phase of the biotic crisis. The
peak of the biotic crisis is characterized by an absence of trace fossils,
increased organic matter content, an increased Mo∕Al ratio, and negative CIE and
δ18O, as well as fewer specialist forms and more opportunists.
This biotic crisis peak is related to oxygen-depleted conditions in the
bottom waters and in the sediment pore water, while warming negatively
affected microfauna – to the point of leaving a barren benthic horizon in
the record. Recovery is evidenced by the occurrence of carbonate layers with
hummocky cross-stratification and a decrease in organic matter content, the
Mo∕Al ratio, and the trace fossil record. In terms of microfauna, the
first phase of recovery shows highly abundant foraminifera, ostracods, and
microgastropods, mainly opportunist forms. After the proliferation of
opportunist forms, a second phase of recovery is marked by a progressive
increase in α diversity.
El juramento de José Antonio Aguirre, una toma de posesión en la Guerra Civil
Authors: Domínguez Ricardo
Published: December 2020

La investigación estudia el tratamiento periodístico de la toma de posesión del lehendakari José Antonio Aguirre en la prensa de la época. Se trata de una ceremonia considerada como un hecho histórico de gran importancia en la construcción simbólica del País Vasco, que tiene lugar en plena Guerra Civil. A través del análisis de las noticias publicadas, ahondamos en el uso, tanto por parte del bando republicano como por el franquista, de los medios de comunicación como actores y transmisores políticos de la propaganda
Escenarios de un remordimiento. Ciudad Universitaria y Guerra Civil en Muerte de un ciclista (Juan Antonio Bardem, 1955)
Authors: Deltell Luis , García Sahagún Marta
Published: December 2020

Este trabajo analiza Muerte de un ciclista (Juan Antonio Bardem, 1955) como una película-evento, film-événement, e investiga la resignificación que su director otorga al espacio de la Ciudad Universitaria de Madrid. La película de Bardem se presenta como el primer film español que muestra un relato diferente de las consecuencias de la Guerra Civil en el bando vencedor y utiliza la Universidad y su valor como ejemplo de territorio crítico al régimen, sirviendo de antecedente simbólico para las primeras manifestaciones de estudiantes en España durante el franquismo
La imagen del antifascismo. La representación propagandística del enemigo del Frente Popular en el estallido de la guerra civil española
Authors: Sevillano Francisco
Published: December 2020

Este trabajo tiene por objeto el análisis de la propaganda republicana y obrera en España tras el golpe de Estado del 18 de julio de 1936 y el estallido de la guerra civil. En este estudio se destaca sobre todo la importancia de la representación del «enemigo» en la construcción de una «cultura de guerra», señalándose los principales procedimientos semánticos y discursivos que empleó la prensa al respecto.
Adoctrinar con la palabra: prensa y propaganda nacionalsocialista en la España de la Guerra Civil
Authors: Almeida Antonio S.
Published: December 2020

La estratégica posición de la Península Ibérica y del territorio insular en el Atlántico con el archipiélago Canario, convirtió a España en uno de los principales focos de la propaganda exterior de la Alemania Nazi. Si bien es cierto que los estudios sobre la propaganda nacionalsocialista han sido un tema bastante estudiado, lo que no ha sido tan frecuente es el análisis de cómo se integró esa propaganda en la prensa de las islas Canarias, durante el período de la Guerra Civil; quienes fueron los protagonistas, qué vinculaciones tenían con el NSDAP, así como qué espacios de actuación implementaron para que su ideología se plasmase en la prensa. En el artículo se identificarán algunas de las líneas editoriales utilizadas por la prensa como medio de propaganda del nacionalsocialismo
Emprender e innovar para crear empleo en Periodismo
Authors: Peinado y Miguel Fernando , Rodríguez Barba Dolores
Published: December 2020

Este trabajo cuenta cómo se puede ayudar a los futuros alumnos de Periodismo de la UCM a incorporarse al mercado laboral mediante la creación de micro-pymes. Formarles para que puedan emprender y compartir experiencias, fomentar ideas e interactuar con mentores internos y externos, que les aporten beneficios retributivos dignos por esa labor. La metodología aplicada es el modelo lean startup que evalúa y proyecta ideas creativas previas a su lanzamiento al mercado. Casi todos los proyectos especializados muestran tendencias favorables de negocio y encuentran razones de mercado para un lanzamiento a corto – medio plazo.
A General Model of Buddhism-Based Management
Authors: Takei Hideki
Published: December 2020

Buddhism-based management has been popular among businesspersons.  However, many studies about the business seemed subjective as authors used their values and interpretations of Buddhism (Weerasinghe, Thisera, and Kumara, 2014; Ashtankar, 2015; Shakya, 2017).  We agree with Abe's (2007) conclusion that the absence of a generally accepted Buddhism-based business model is the leading cause. We need a general model.  This paper suggests a generally accepted Buddhism-based business model by integrating all aspects of Buddhism-based business from published studies and the Buddha's original teachings.  We will then use a Japanese Buddhism-based company, Warehouse TERRADA Co, to verify this model.
Knowledge Management as Support for Innovation of Public Projects
Authors: Lima Camila Marques de , Filho Flávio De São Pedro , Silva Elca Pereira da , Araujo Tiago Garcia , Paim Francisco Alexandre Bellinassi
Published: December 2020

Knowledge is an important organizational asset and it is essential to ensure efficient performance and competitiveness. Knowledge Management (KM) appears, therefore, as an important tool to guarantee the identification, absorption, creation, sharing and application of organizational knowledge. Innovation is seen as the creation or improvement of methods, practices, technology, product or service. In this scenario, this research had as a general objective to carry out a study of the conceptual foundations of Knowledge Management which are valid for innovation in public projects and as specific objectives to carry out a theoretical-conceptual survey on Knowledge Management, characterize the relationship between Knowledge Management and innovation and point out the valid indications in this study that support the innovation of public projects. The question to be answered was: How can Knowledge Management be used to support innovation in public projects? This research was elaborated through the Content Analysis Method and presented, as a result, the conclusion that the KM process as a whole has practices that aim to create in an organizational environment conducive to the emergence of innovative thinking encouraging the sharing of knowledge and experiences, the search for solutions and making individuals better qualified.
Building an Attitude Scale about E-learning among Isra University Students according to the Item Response Theory in Measurement
Authors: Al-Dlalah Mohammad , Alkhaldi Hani , Alkhutaba Malek , Al-Momani Taghreed
Published: December 2020

Nowadays, E-learning is one of the most inevitable technique and learning approach, because it offers indispensable advancement of the education process. Furthermore, it supports and enhances many facets of the learning process. This study aimed to build an attitude scale about e-learning among Isra University students according to the item response theory (IRT) in measurement. To achieve the study’s objectives, the main dimensions of the scale were identified, and 44 items were unevenly formatted. The tool was applied to 550 students who were social media users at Isra University. After analyzing the participants’ responses according to IRT, the final form of the scale consisted of 29 items that were divided into three main dimensions. The reliability of the scale was 0.94%, while the scale had multiple indications of validation.
Earthquake risk buildings
Authors: Hopkins D. C. , Robertson T. W.
Published: December 2020

The seismic provisions of the New Zealand Loadings Code are regarded as providing an acceptably low risk to life and property. However, the majority of existing buildings do not meet these requirements, some to a disturbing degree.  The paper describes a selection of buildings both pre- and post- 1935 which were assessed by the authors' firm for earthquake risk. On the basis of this experience recommendations are made for the expansion and rationalisation of the present guidelines for assessment and structural upgrading of existing buildings.
Outline of earthquake provisions in the recently revised Japanese building code
Authors: Aoyama Hiroyuki
Published: December 2020

The revised building code of Japan, to become effective in June, 1981, is reviewed. It features a two-phase design for earthquakes. The first phase design is for medium earthquake motions, and this is basically the unchanged traditional seismic design. The new second phase design is intended to give protection to buildings in case of severe ground shaking. It requires the checking of several aspects of the building that has been proportioned by the first phase design. These include storey drift, vertical stiffness distribution, horizontal accentricity and ultimate lateral load carrying capacity. Both phases of the design are reviewed in detail, with some numerical examples where it is appropriate to illustrate the design procedure. Some provisions are discussed in the light of recent earthquake damage in Japan. A comparison with New Zealand seismic design loadings is also made.
Selective Anomeric Deacetylation of Per-Acetylated Carbohydrates Using (i-Pr)3Sn(OEt) and Synthesis of New Derivatives
Authors: Jabbari Hadi
Published: December 2020

In this study natural carbohydrates such as glucose, galactose, xylose, fructose andlactose, are acetylated by acetic anhydride and sodium acetate catalyst. Anomeric configuration is deacetylated by (i-Pr)3Sn(OEt)as a catalyst, an easy synthetic regioselective deacetylation of full acetylated carbohydrates using (i--Pr)3Sn(OEt) is described. The acetylated carbohydrates reacted with HBr (solution in AcOH, 32 wt.%) for the bromination of anomeric position. The synthesis oxazaphosphorine, and bromo hexa alkyl Methylsulfonate derivatives from anomeric position of carbohydrates was reacted. FT IR, 1H, 13C NMR, 31PNMR spectroscopy techniques were employed to examine the synthesized compounds.
CONFLICT RESOLUTION STYLES PREFERRED
BY SCHOOLCHILDREN WITH VARYING DEGREES
OF SOCIAL ADAPTATION
Authors: Lewicka -Zelent Agnieszka , Pytka Agnieszka
Published: December 2020

Conflicts are an integral part of people’s lives, regardless of their age. This aspect of life evokes many negative connotations. Nevertheless, the advantages of confl icts are now often exposed, providing that they are solved in a constructive way. The adolescent period is a stage of life that undoubtedly favours the frequency and intensity of diffi cult interpersonal situations. Therefore, the researchers decided to analyse which confl ict resolution styles are favoured by youth. The research was conducted in a group of one hundred and twentytwo secondary school students, half of whom were minors. A diagnostic opinion poll was applied. To be precise, it was the Confl ict Mode Instrument of Thomas and Kilmann. From the data obtained it stems that the minors, in comparison to the youth who are not under the supervision of a probation offi cer, are less likely to give up their own needs and interests on behalf of their partner in confl ict. However, equally often, people from the comparison groups solve confl icts by competing, looking for a compromise, using escaping mechanisms as well as cooperating with the confl ict partner. This means that it is worth applying negotiation and mediation as a preventative measure to prevent the escalation of the symptoms of social maladjustment.
GLOSS TO THE DECISION OF THE SUPREME
COURT OF 5 SEPTEMBER 2019, I KZP 7/19
Authors: Kazimierski Grzegorz
Published: December 2020

Both parents, if they have full parental rights, are persons “obliged to exercise care and responsibility over a minor under 15 years of age” within the meaning of Article 211 of the Criminal Code (CC). Conversely, the parents (or one of them at least) are capable of committing the off ence set out in Article 211 of the CC if their parental rights are terminated, limited or suspended. If a provisional decision of a court, issued in the course of divorce, separation or annulment of marriage proceedings, orders the limitation (termination, suspension) of parental rights of one of the parents, such a decision should, as a rule, be interpreted literally. As such, a parent who no longer enjoys full parental rights under such decision can potentially commit the off ence set out in Article 211 of the CC. Nevertheless, not every court decision which provisionally determines the extent of contacts between a child and a parent, is tantamount to limiting parental rights. Indeed, under Article 107 of the Family and Guardianship Code it is possible to determine such contacts, including severe limitations for the father or the mother in this respect, while leaving both parents’ full parental rights intact.
Statistical Analysis of the Results of Test Artillery Tracers
Authors: AMPUŁA Dariusz
Published: December 2020

A statistical analysis of multiyear laboratory test results of artillery tracers number 8 is presented in this article. This analysis was aimed at testing the impact of a natural ageing process on quality indicators during the long-time storage of these tracers. The influence of storage time on taking a diagnostic decision, relating to quality of lots after the conducted laboratory tests and on different classes of inconsistencies that occurred during these tests, was analysed. A detailed analysis of the impact of the storage time on diagnostic shooting decisions taken was also presented. The conducted statistical analysis suggests an assumption, that it is possible to change an evaluation module in the previous test’s methodology. Modification of this evaluation module will not negatively impact on the quality of further diagnostic tests. It will not negatively impact on correct evaluation of the prediction process of the tested elements of ammunition such as artillery tracers. The statistical analysis, carried out in the article, may have a significant impact on the modification of test methodology of the artillery tracers.
The Use of Virtual Reality for Training in Securing the Functioning of Critical Infrastructure
Authors: GRABOWSKI Andrzej , WODZYŃSKI Mieszko
Published: December 2020

Our national security, economic prosperity and national welfare depend on a set of highly interdependent elements of critical infrastructure. Examples of critical infrastructure facilities include the national electricity grid, oil and gas systems, telecommunication and information networks, transportation networks, water systems and banking and financial systems. Given their importance, it is crucial to maintain the reliability of critical infrastructure facilities, especially power plants, both in times of peace and also in times of crisis or under conditions of attack. For this purpose, on the one hand, it is possible to improve and create new technical solutions supporting the restoration of the proper functioning of critical infrastructure facilities, such
as remotely controlled mobile robots for example. On the other hand, it is important to prepare employees to operate in unusual conditions by organising appropriate training. In both cases, it can be useful to apply virtual reality techniques.
Wie betriebliche Mitbestimmung sozioökonomische Reflexion in Zeiten digitaler Transformation bewahren kann
Authors: Spindler Eva
Published: December 2020

Die digitale Transformation birgt für Unternehmen und die betriebliche Mitbestimmung vielfältige Herausforderungen. Der Unternehmensvertretung tritt die betriebliche Mitbestimmung bei inhaltlichen Fragen in sozioökonomischen Reflexionsräumen entgegen. Um in diesen Reflexionsräumen auch zukünftig als kompetenter Partner agieren zu können, bedarf es struktureller Veränderungen, umfassender Qualifizierung und einer Auseinandersetzung mit den künftigen Bedürfnissen der Zielgruppe.
Schwächen privater Regulierung globaler Güterketten durch Siegel
Authors: Graf Jakob
Published: December 2020

Aufgrund von Klimawandel und Waldbränden rückt auch das globale Forstmanagement wieder ins öffentliche Interesse. Einer der wichtigsten Akteure ist dabei der ›Forest Stewardship Council‹ (FSC), welcher Forstprodukte zertifiziert. Der vorliegende Beitrag argumentiert, dass private Regulierungsmechanismen wie der FSC systematische Schwächen aufweisen und zeigt am Fall der chilenischen Forstindustrie, dass dies insbesondere für die Regulierung globaler extraktivistischer Güterketten gilt.
The Difficulties of Understanding
Authors: Arendt Hannah ,   Philosophy Documentation Center
Published: December 2020

For the inaugural issue of the Journal of Continental Philosophy the editors have republished this decisive text in the arc of Hannah Arendt’s thought. In this text she orients us towards the totalitarian impulses inherent to modernity as such. Her text is presented in its various iterations, reprinted with permission from The Modern Challenge to Tradition: Fragmente eines Buches (Göttingen: Wallstein Verlag, 2018), volume VI of the Critical Edition of the Complete Works of Hannah Arendt.
The Human Genome
Authors: Bergman Gerald ,   Institute for Interdisciplinary Research
Published: December 2020

This essay explores the influence of randomness in genetic change based on findings in the scientific literature. In many cases, random mutations are not the source of genetic variation that allows adaptation to an environmental change. Rather, innate mechanisms are the cause. Typical examples are used to illustrate how these systems work, and the evidence for them. Randomness appears to have less effect in causing micro-evolution then once assumed. But it has a significant influence in causing near neutral and deleterious mutations, resulting in genetic entropy. Some random mutations have a beneficial effect. However, all are due to gene damage that in some situations have limited beneficial effects. This suggests that major steps should be taken by the medical community to help ameliorate the adverse effects of random mutations on the human genome.
Does God Gamble With Creation?
Authors: Polis Dennis F. ,   Institute for Interdisciplinary Research
Published: December 2020

Despite Albert Einstein’s claim that “God does not throw dice,” it is widely believed that quantum physics presents an intrinsically random universe. This conflicts with the theological view that nature operates in one and the same way, unless it be prevented as a result of divine providence. A proposed projection paradigm is based on respect for the integrity of each science. Apparent conflicts between science and theology may be resolved by the consistent application of the principles of science, each within its valid domain. Using this approach, paradoxes are found to involve a covert Platonism among quantum theory’s interpreters. Rather than endorsing an interpretive hypothesis, this essay seeks to apply accepted physics to quandaries posed by quantum theory.
The Postmodern Challenge
Authors: Gruenwald Oskar ,   Institute for Interdisciplinary Research
Published: December 2020

The thesis of this essay is that the central postmodern challenge is to recover stable, objective normative standards that presuppose cultural renewal and liberal arts education building on the classical paideia of educating the whole person. Humans possess an innate moral sense that requires nurturing and developing to encompass both résumé and eulogy virtues as proposed by David Brooks’ The Road to Character. Wisdom-seeking traditions aim at self-mastery, but need tempering by neo-Kantian epistemological modesty to eschew utopias in their quest for transcendence, recalling the Augustinian conception of humanity’s fallen nature, the need for community, the aspiration for good works in the City of Man, and the soul’s yearning for redemption and salvation in the City of God. The essay concludes with the “Angel Initiative” as an example of practical wisdom that reflects Brooks’ humility code, the wisdom-seeking traditions’ emphasis on the Way, and Christianity’s promise as “a religion of second chances.”
Cultural Institutions, Theatre and Humanistic Liberal Education
Authors: Lee J. Scott ,   Institute for Interdisciplinary Research
Published: December 2020

The purported crisis and opportunity in liberal education may be approached via a reconsideration of the arts in liberal arts education. The advantage of such a view is that proponents of humanistic liberal education could speak in their own terms, while incorporating in a systematic way studies of ancient and modern liberal arts, addressing public questions of the value and substance of a liberal education. A plausible issue for consideration is whether the “arts” can address a crisis, its purported causes and solutions, and the key role the humanities may have in building a renewed liberal arts education. At stake in the classroom is the realization of the possibilities, the intellectual freedom, which humans make for themselves in artistic making. This freedom differs from, but is complementary to, political freedom, the loadstone of standard liberal education defenses, because it is based in innovations and inventions of the arts and sciences, not in constitutions or politics of democracy.
Neue Beispiele fuer die Elision von h im Ägyptischen—ein Zwischenbericht
Authors: Bojowald Stefan
Published: December 2020

The focus of this contribution is on the loss of the Egyptian consonant h. The article follows a study by the same the author in JARCE 50 (2014) about the same topic that dealt exclusively with examples from the Middle Kingdom. The time range is extended here to the late material. The starting point is given by writings of individual words on the one hand, and of plays on words on the other. The weakness of h is not restricted to the Egyptian language, but can also be observed in other oriental idioms.
Compositional Format and Spell Sequencing in Early Versions of the Book of the Dead
Authors: Dorman Peter
Published: December 2020

Recent studies of the early development of the Book of the Dead have tended to focus on the content of this group of spells, the objects on which the spells are written, the sequences in which they occur, and their early prototypes, which appear on Middle Kingdom coffins. The physical presentation of the first texts that can be described as fully in the Book of the Dead tradition, however, illustrates how scribes addressed the challenges of transmission of this mortuary corpus hand in hand with the evolution of novel burial practices in the Theban region beginning in the late Second Intermediate period, including the introduction of anthropomorphic coffins, linen shrouds, and papyrus rolls. Both hieratic and cursive hieroglyphic scripts were employed on these media, along with compositional formats suitable to them, as well as the appearance of scribal sketches that evolved into the vignettes for which the quintessential New Kingdom Books of the Dead are justly renowned. An “Ahmoside” sequencing tradition prior to the co-rule of Hatshepsut/Thutmose III is further defined, and the codicil to BD 72 is examined for its relation to the use of linen versus papyrus in Theban burials of the period.
Dental Prosthesis: Postmortem Treatment of Oral Reconstruction during the Mummification Process
Authors: Hashesh Zeinab , Herrerín Jesús
Published: December 2020

During excavations carried out in 2014 at Tell Tebilla, Egypt, three tombs were discovered inside a mud-brick mastaba, each one with an individual interment. The occupant of the second tomb was of great interest. It was a partially mummified man about 60 years old, named Wah ib Ra, a priest of Sekhmet. The detailed study of his skull and jaw revealed that this man had lost most of his teeth in life, long before his death. However, we discovered that new false teeth were carefully embedded during the mummification process in the gaps caused by antemortem teeth loss. To perform this maneuver, a white material was used as glue. Chemical analysis performed on this white material confirmed that it was anhydrite (CaSO4), which is the dehydrated form of plaster. Although the final result was successful, the embalmers made several errors in both the placement and the type of new teeth used. This performance of the embalmers can be framed within the actions already described as “prosthesis for the afterlife,” in which mummification would not only be a process to avoid putrefaction but also a moment in which the embalmers would try to rebuild, or improve the body in order for the individual to enjoy an eternal life without the problems or illnesses suffered in earthly life.
ILat Novae 39: A New Interpretation of the Titulus Pictus from Novae
Authors: Okon Danuta
Published: December 2020

The article discusses two new readings of line 5 of titulus pictus from (ILatNovae 39). According to the first one, line 5 is to be read as C(aio) Sam(bucio) C(ai) f(ilio) Q(ui- rina) Maiore, and the person mentioned is considered a senatorial legate. According to the other one, line 5 is to be read as C(aio) Sam(mio) C(ai) f(ilio) Q(uirina)/O(ufen- tina) Maiore, and the person mentioned is considered a centurion.
Angiogenesis in glioblastoma: Molecular and cellular mechanisms and clinical applications
Authors: Tasić Desanka , Dimov Irena , Kostov Miloš , Vidović Nataša , Dimov Dragan
Published: December 2020

Glioblastoma (GBM) is the most common malignant primary brain tumor in adults and carries poor prognosis. Despite advances in therapy, no significant increase in survival has been achieved for GBM patients. These tumors inevitably recur in the majority of patients, and the therapeutic options for recurrent tumors are limited. GBMs are aggressive, fast-growing, and highly infiltrative tumors, with exuberant angiogenesis (microvascular proliferation) and necrosis. However, the newly formed tumor vessels are structurally and functionally abnormal, creating areas of hypoxia and ultimately necrosis, contributing to tumor progression and aggressiveness. Since GBMs are hypervascular in nature, targeting tumor angiogenesis emerged as a promising therapeutic strategy. In this review, we summarized the molecular and cellular mechanisms governing GBM angiogenesis, the other modes of tumor vascularization, and the key mediators of these processes. We also discussed the importance of tumor hypoxia in promoting angiogenic and vasculogenic processes, the contributions of GBM stem cells to tumor vasculature, the anti-angiogenic therapy for GBM, and the resistance to such therapy. A better understanding of the molecular and cellular basis of GBM neovascularization, the mechanisms of resistance to therapy, and the contributions of GBM stem cells to tumor vasculature will lead to the development of more effective treatment strategies.
Press release the fairness of ethical decisions related to the allocation of medical resources within the COVID-19 pandemic
Authors: Raffay Violetta , Lazić Aleksandra , Fišer Zlatko
Published: December 2020

The fairness of ethical decisions related to the allocation of medical resources within the COVID-19 pandemic The Serbian Resuscitation Council discussed, considered, and adopted based on the National Course Director leaders opinion consensus in the field of resuscitation medicine about the basic principles of resource allocations, related to the application of resuscitation procedures and care of patients during the pandemics. The COVID-19 pandemic around the world has brought a lot of changes within all segments of life, we all are faced to everyday challenges, including ethics in medicine, which is a very sensitive area due to specifics that are unique and different in each country individually, with strong cultural, economic, religious, medical, legal, and other diversities. The challenges are enormous, given by the current lack of a specific therapy, by the limited resources available for diagnosis, intervention, and preventive measures. The pandemic also brought the need to create conditions for the application of "unusual" requirements, measures, and procedures of the healthcare system and medical care, which entails a certain reorganization of medical interventions and care systems, including mandatory personal protection measures, adherence to adequate social distance, and all hygienic procedures. General ethical principles, such as maximum benefit and equality of treatment, while giving priority to those with the most severe conditions, have created the need to create ethical recommendations related to the allocation of medical resources in the COVID-19 pandemic and Eziekel et al. published six principles related to the above in terms of maximizing benefits, giving an advantage to healthcare professionals, triage outside the framework of the "first arrival" basis, responding to findings, recognizing participation in research, and applying the same principles to COVID-19 and in non-COVID-19 patients. A fair allocation of these ethical values and principles requires adaptable ethical frameworks depending on the resources available and the organizational structure of the healthcare system.
Oral health in patients with chronic kidney disease
Authors: Stolić Radojica , Mitrović Vekoslav , Suljković Naja , Miljković-Jakšić Dušica , Balović Aleksandra , Krivčević Roksanda , Jovanović Sanja
Published: December 2020

Objective: In the available literature data, there is not much information about problems of patients with end stage kidney disease in relation to oral health. Our objective was to show the importance of oral diseases for patients on hemodialysis. Data sources: In this review article, the sources of data are review articles and scientific articles in the English language published in MEDLINE database. The choice of studies was based on keywords: Chronic kidney disease, Hemodialysis, Oral health, Periodontal diseases. Results: It is assumed that almost 90% patients with chronic kidney disease manifest some symptoms of oral disease. Therefore, it is important to determine the impact of periodontal disease on the progression of kidney failure in these individuals, to evaluate inflammatory parameters in this patient population, to assess the degree of bone loss and periodontal disease index, to determine the presence of bacterial strains, paradontopathy of gingival fluid and antibody titers, to examine correlations of proinflammatory cytokines in the gingival sulcus and serum, as well as to determine the relationship between periodontal tissue and inflammatory mediators. Periodontal diseases can increase the possibility of developing chronic kidney disease by 1.5 to 2 times. These oral diseases include gingival hyperplasia, periodontitis, xerostomia, unpleasant breath, changes in the oral mucosa, malignancies, oral infections, dental abnormalities and bone lesions. Conclusion: This requires serious cooperation between nephrologists and dentists to make proper communication possible, in order to provide quality dental care for this growing patient population in accordance with new treatment strategies.
Mehanizam kontrakcije i relaksacije miometrijuma, interakcija okcitocina i prostaglandina
Authors: Relić Goran , Mujović Vujadin , Šulović Nenad , Minić Slaviša
Published: December 2020

Regulation of uterine activity during pregnancy is due to the nature of the loss of humoral sympathetic, holinergical and peptidergic inervation. So far, nothing found that would indicated that the mechanism of premature birth and its pathogenesis different from the normal mechanism of delivery, except for different maturity of the fetus. Since a large number of substances that participate in the contraction and relaxation of miometrium (estrogen, progesterone, cortisol, etc.). Today's modern research has focused on prostaglandins and oxytocin, or their interaction. Accepting oxytocin as substance initiation deliveries it is difficult for two reasons: the level of oxytocin in the blood can not lift before the delivery and release of oxytocin remains constant during pregnancy. Oxytocin probably plays a role in support delivery for decidual cells stimulates the synthesis of uterine PGF2a.
Jarisch-Herxheimer reaction during therapy of neuroborreliosis
Authors: Knežević Snežana , Vulović Jelena , Jandrić-Kočić Marijana
Published: December 2020

Introduction. Jarisch-Herxheimer reaction implies trembling, headache, temperature, rash, meningitis, respiratory problems, liver, kidney and heart dysfunction during antibiotic treatment of Lyme disease. Case outline. A 47-year-old patient in May 2016 had circular redness on the thigh, fatigue, myalgia, nausea and headache. Borrelia Burgdorferi IgM antibodies were positive. She took doxycycline 200 mg/day, four weeks. Western blot IgM and IgG were positive as well. Retreated with Azithromycin, 500 mg/day, three weeks. Next year, there was a sleep and memory disorder, fatigue, dizziness, right leg paresthesia and burning in the soles, muscle weakness, decreased sensitivity and right foot hyperreflexia. Electromyography showed axonal degeneration of the peroneus and the tibialis. Pleocytosis (5 leucocytes/mm³) and intrathecal IgG were found. Magnetic resonance of the head in order. Neuroborreliosis was diagnosed and treatment included ceftriaxone, 2 grams/day, three weeks. After the second dose, trembling, myalgia, headache, nausea, flushed nose, dizziness and nausea started. Temperature 37.8°C. No changes on the skin. The antibiotic was not interrupted, symptomatic therapy was administered, and after two days the symptoms stopped. Neurological disorders have not completely disappeared. Titre antibodies still present. Conclusion. Jarisch-Herxheimer reaction occurs in 7.0-30.0% of patients treated for Lyme disease. Causes are multifactorial. Spirochetes release toxins, hypersensitivity is present, phagocytes destroy agents, complements and cytokines are activated. It is often not recognized. Tremor, fever, myalgia and skin rashes are present before the antibiotic, and the worsening is attributed to the underlying disease or allergy. Doctors should expect it during the treatment of spirochete-related diseases and provide appropriate care.
Fiscal policy measures in the Corona virus period
Authors: Ćeha Nikola , Ćeha Milenko
Published: December 2020

Fiscal policy measures are necessary weapons to overcome the economic crisis caused by the Coronavirus. State intervention and implementation of adequate measures can significantly protect the domestic economy and thus speed up the recovery. The focus of the paper are the fiscal policy measures implemented by the Republic of Serbia during and after the introduction of the state of emergency, as well as plans for the measures in the future. As a country in transition with lower economic growth than other EU member states, Serbia has followed the trends of implementing fiscal policy measures following the example of the most powerful economies in the world. Relevant international and domestic sources were used for the analysis. The results of the research show that Serbia has implemented adequate measures to overcome the crisis, but in comparison with the countries of the European Union, providing financial resources is one of the biggest problems in the given period.