bluuebunny/crossref_metadata_2025 huggingface dataset:
A cross-sectional report on the use of high doses of melatonin in humans.
Authors: Valiensi Stella M , Folgueira Agustín L , Vera Vanesa A , González Cardoso Agustín , Cardinali Daniel Pedro
Published: December 2024

The administration of melatonin in chronobiotic doses (≤10 mg daily) is a common procedure in clinics. In addition, research in animals has led to greater awareness on the potentiality of melatonin as an antioxidant, immunological and mitochondrial regulator and anti-inflammatory compound. Doses allometrically derived from animal studies correspond to 75 to 112.5 mg daily range for a 75 kg human adult. In view of the absence of toxicity of melatonin in phase 1 pharmacological studies with doses up to 100 mg in normal volunteers, we regularly use melatonin in this dose range to treat sleep disorders in aged patients to prevent age-related comorbidities. In an observational, analytical, retrospective, cross-sectional study of clinical history data from a closed population of patients taking melatonin in doses equal to or greater than 40 mg/day of melatonin for various sleep disorders, 80 patients (74.2 % female, mean age 74 years ± 9.26) were included. The indication of melatonin doses varied between 40 and 200 mg per day, with a mean of 76.56 mg ± 33.58 mg daily. The main reason for indication was complaints of disorders in falling asleep or maintaining sleep with melatonin doses varying depending on the comorbidities clinically detected. The 59 % of patients received treatment for more than 4 years.  Laboratory variables related to liver function remain within the normal range after melatonin administration regardless of the dose employed. No relation was also found between melatonin dose and concomitant pharmacological treatment. The results advocate for the safe use of melatonin in higher doses than those commonly employed.
Current state of the natural melatonin: the phytomelatonin market
Authors: Cano Antonio , Hernández-Ruiz Josefa , Arnao Marino Bañón
Published: December 2024

Melatonin is a dietary supplement substance widely distributed in the global market and its therapeutic use has been significantly expanded from its original use to target the jet-lag. In this report, we have discussed the current situation of the natural melatonin market, an “alternative melatonin” to chemically synthesized melatonin, with exclusive characteristics and possibilities, to focus on a more selective, eco-friendly market that orients its consumption to natural and healthy products. The different possibilities obtained melatonin from genetically modified organisms to phytomelatonin which are extracted from algae/microalgae or medicinal plants are discussed.
Perbandingan Algoritma C4.5 dengan Naïve Bayes untuk Menduga Loyalitas Pelanggan pada Perusahaan Internet Service Provider.
Authors: Kurniawan Maranto Ardiane Rossi , Liliy Damayanti  , Irvan Rahul Ramadika
Published: December 2024

Industri Internet Service Provider (ISP) menghadapi persaingan yang ketat, sehingga loyalitas pelanggan menjadi aspek penting bagi keberlanjutan bisnis. Loyalitas pelanggan tidak hanya mendukung pendapatan stabil tetapi juga meningkatkan reputasi perusahaan. Penelitian ini membandingkan performa algoritma C4.5 dan Naïve Bayes dalam memprediksi loyalitas pelanggan ISP, memberikan wawasan untuk menentukan metode yang lebih efektif dalam analisis data pelanggan. Penelitian menggunakan pendekatan eksperimen dengan framework CRISP-DM. Data diambil dari pelanggan yang mengajukan penghentian layanan hingga akhir tahun 2020, mencakup atribut seperti alasan penghentian, jenis produk, metode penghentian, dan data demografis. Validasi dilakukan menggunakan 10-fold cross-validation, dengan evaluasi kinerja berdasarkan metrik akurasi, precision, recall, dan AUC-ROC. Hasil menunjukkan bahwa algoritma C4.5 memiliki performa lebih unggul dibandingkan Naïve Bayes, dengan akurasi sebesar 80,67% dan AUC 0,830, dibandingkan Naïve Bayes yang memiliki akurasi 76,23% dan AUC 0,824. Algoritma C4.5 lebih akurat dalam membedakan pelanggan loyal dan tidak loyal. Penelitian ini menyimpulkan bahwa algoritma C4.5 lebih efektif untuk menduga loyalitas pelanggan ISP. Hasil ini memberikan rekomendasi strategis bagi perusahaan ISP untuk meningkatkan pengelolaan pelanggan melalui analisis data yang lebih optimal.
Identifikasi Malaria Pada Citra Darah Dengan Convolutional Neural Network
Authors: Purnomo Juanda Gilang , Birowo Sigit , Maulana Muhammad Akbar
Published: December 2024

Penelitian ini membahas penerapan model pretrained EfficientNetV2S dan ConvNeXtBase untuk mendeteksi keberadaan parasit malaria dalam citra darah mikroskopis. Dataset yang digunakan terdiri dari 27.588 citra darah manusia, yang terbagi menjadi dua kategori, yaitu Parasitized dan Uninfected. Model dilatih menggunakan dua pengaturan learning rate: minimum (0.0001) dan maksimum (0.001), untuk membandingkan performa dan stabilitasnya dalam proses klasifikasi. Hasil penelitian menunjukkan bahwa model EfficientNetV2S dengan learning rate minimum mencapai akurasi validasi tertinggi sebesar 96,58%, mengungguli model ConvNeXtBase yang hanya mencapai akurasi maksimal sebesar 70,51%. Selain itu, model EfficientNetV2S menunjukkan efisiensi komputasi yang lebih tinggi, menjadikannya pilihan yang lebih tepat untuk tugas deteksi malaria berbasis deep learning.Namun, penelitian ini juga mengidentifikasi beberapa tantangan, termasuk masalah overfitting dan underfitting, yang dapat memengaruhi keandalan model ketika diterapkan pada dataset yang lebih besar atau lebih kompleks. Analisis lebih lanjut terhadap matriks kebingungan (confusion matrix) menunjukkan bahwa model EfficientNetV2S memiliki tingkat presisi dan recall yang konsisten di atas 94% untuk kedua kategori (Parasitized dan Uninfected), sementara ConvNeXtBase menunjukkan fluktuasi performa yang lebih signifikan.Penelitian ini menyarankan eksplorasi model yang lebih kompleks, penerapan teknik data augmentation lanjutan, serta pengujian pada dataset yang lebih beragam untuk meningkatkan stabilitas dan akurasi prediksi. Penggunaan pendekatan berbasis deep learning dalam deteksi malaria memberikan potensi besar untuk mendukung proses diagnosis medis, terutama di wilayah dengan keterbatasan akses ke layanan kesehatan konvensional. Dengan model yang lebih efisien dan stabil, sistem ini diharapkan dapat diterapkan secara luas untuk membantu mengurangi dampak penyakit malaria di berbagai negara, termasuk Indonesia.
Implementasi Metode TOPSIS Pada Sistem Pendukung Keputusan Pemilihan Depot Air Minum Isi Ulang
Authors: Sari Dian Permata , Meri Rozi , Buana Wira , Sari Mike Febri Mayang
Published: December 2024

Air adalah kebutuhan dasar bagi semua makhluk hidup, dan keberadaannya sangat penting untuk kelangsungan hidup. Seiring dengan meningkatnya permintaan akan air, ketersediaan air bersih tidak selalu sebanding, sehingga banyak masyarakat yang memilih air minum isi ulang yang praktis dan terjangkau. Masyarakat diharapkan bijak dalam memilih depot air minum yang higienis dan sehat sesuai dengan standar yang ditetapkan oleh pemerintah. Metode TOPSIS, yang merupakan bagian dari Sistem Pendukung Keputusan, dapat membantu dalam memilih depot air minum isi ulang yang sehat. TOPSIS adalah metode pengambilan keputusan multikriteria yang menggunakan prinsip bahwa alternatif yang dipilih harus memiliki jarak terdekat dengan solusi ideal positif dan jarak terjauh dari solusi ideal negatif. Ada empat variabel yang digunakan untuk memilih depot air minum isi ulang yang sehat, yaitu kualitas air, sanitasi penjamah, peralatan, dan kelengkapan. Hasil analisis dengan metode TOPSIS memberikan rekomendasi depot air minum yang sehat. Berdasarkan perhitungan nilai preferensi, alternatif V1 memperoleh nilai tertinggi sebesar 0.87188, diikuti oleh alternatif V13 dengan nilai 0.84037, dan seterusnya. Dengan demikian, alternatif V1 direkomendasikan sebagai depot air minum isi ulang yang terbaik. Sistem pendukung keputusan dengan metode TOPSIS dapat dijadikan panduan dalam pemilihan depot air minum isi ulang.
Collaborative E-Learning Model Development for Increase Quality Learning in Vocational School
Authors: Kurnaedi Didi , Widyarto Setyawan
Published: December 2024

The creation of a collaborative e-learning model is an urgent need, especially in Tangerang, to improve the quality of education in Vocational High Schools (SMK). Vocational learning requires integration between theory and practice, but traditional e-learning systems have not been able to meet this need. This study aims to develop a personal collaborative e-learning model that combines interactive support-based learning, context-based collaboration, and practice-oriented learning. The research methodology uses the ADDIE model  with a Research and Development  approach. The subjects of the study involved 22 teachers and 375 students from various vocational schools in Tangerang. Data collection was carried out through questionnaires, observations, interviews, and test results, with three trial classes for one semester. The results showed that the collaborative e-learning paradigm significantly increased student engagement, learning quality, and learning outcomes. As many as 82% of students felt their learning experience was more meaningful than the previous e-learning method, while 85% of students actively participated in discussion forums and collaboration. The test results showed an average increase in scores of 15%. Teachers also assessed that this strategy supports the development of students' practical skills and facilitates project-based learning. Satisfaction evaluations showed that 80% of students felt more satisfied with the learning experience using this collaborative model. The collaborative e-learning model developed is not only relevant for learning in SMK Tangerang, but also has the potential to improve the standard of vocational education in Indonesia. Training and infrastructure support are needed to ensure the sustainability of the implementation of this model.
Management dan Monitoring Real Time Access User Internet Sehat Kota Prabumulih
Authors: Sisco Dicofran , Sangaji Didi , Sutabri Tata
Published: December 2024

Dunia informasi saat ini tampaknya terkait erat dengan teknologi. Dunia teknis menjadi semakin kompleks akibat penggunaan teknologi oleh masyarakat. Dengan kemajuan teknologi, komunikasi semakin cepat hingga terasa instan. Pepatah “Dunia tidak seluas daun kelor” sudah sepatutnya diubah menjadi “Dunia seluas daun kelor” mengingat betapa cepatnya perkembangan teknologi. Pemerintah kota prabumulih telah memberikan fasilitas internet bersifat gratis guna mendukung kegiatan ekonomi dan pendidikan untuk masyarakat kota prabumulih. Menggunakan internet dengan segala aktifitas akan memberikan kemudahan untuk meningkatkan taraf kehidupan masyarakat dalam usaha yang dijalan, sehingga internet yang baik memiliki nilai yang dapat memungkinkan kerja yang akan dikerjakan dari jauh dimana pun berada. Meningkatkan perekonomian lokal, ini telah menjadi peluang luar biasa untuk menyelesaikan tugas-tugas yang akan ditangani secara online mulai dari pemasaran dan pemesanan hingga promosi produk, yang semuanya dapat diakses langsung melalui media sosial, pelanggan dapat mempelajari bisnis dengan mudah dan cepat. sedangkan dalam dunia pendidikan internet juga memberikan informasi yang sangat lengkap serta muda di akses. Namun penggunaan internet yang tidak terkendali juga dapat menimbulkan dampak buruk, terutama bagi anak-anak dan remaja yang lebih rentan terhadap materi berbahaya. Oleh karena itu, sangat penting untuk menerapkan peraturan internet yang sehat dan menekankan pada akses yang terbatas dan aman. Tujuan penelitian ini berupaya melindungi konsumen dari informasi berbahaya termasuk perjudian, ekstremisme, dan pornografi. Pendekatan Network Development Life Cycle (NDLC) digunakan dalam penelitian ini untuk memungkinkan efektivitas manajemen otentikasi pengguna serta sistem monitoring akses internet real-time di Kota Prabumulih.
Effect of Solvents on Porous Properties of Microporous Polyphenylenes
Authors:   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia, Sorokina S. A. , Kuchkina N. V. ,   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia, Patsaev T. D. ,   National Research Centre "Kurchatov Institute", pl. Akademika Kurchatova 1, Moscow, 123182 Russia, Shifrina Z. B. ,   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia
Published: December 2024

Microporous organic polymers are of considerable interest for the development of gas separation technologies, catalysis, gas storage systems and other areas. This study shows the effect of porogenic solvents (toluene, o-xylene, DMF) on the pore size distribution, volume and content of micropores in microporous polyphenylenes. Using scanning electron microscopy, a strong effect of solvents on the morphology of the resulting polymers was shown. The nitrogen adsorption–desorption isotherms allowed for determining the optimal conditions for the synthesis of soluble microporous polyphenylenes, leading to samples with the highest degree of microporosity.
Intramolecular Excimers of Organic Compounds
Authors:   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia, Belova A. S.
Published: December 2024

Nowadays, the compounds with unique fluorescence and sensor properties attract much attention of researchers. One of the promising classes of compounds are organic fluorophores capable of forming excimers in an excited state. This review highlights intramolecular excimers based on organic compounds, their properties and applications, as well as matrices that are used to graft such fluorophores.
Palladium-Catalyzed Allylation of α-(o-Carboran-1-yl)acetophenone with Allyl Carbonates
Authors:   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia, Shevaldina E. V. , Nelyubina Yu. V. ,   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia, Moiseev S. K. ,   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia
Published: December 2024

The reactions of palladium-catalyzed allylation of o-carboranylacetophenone with allyl carbonates lead to the formation of allylation products in good yields. Depending on the structure of the reagents and their ratio, both monoallylation and diallylation products can be obtained.
Highly Filled Rubber Plastics for Soft Road Surfaces: Effect of a Matrix Composition on the Mechanical Properties
Authors:   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia, Shishkinskaya V. A. , Goncharuk G. P. ,   Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, ul. Profsoyuznaya 70, Moscow, 117393 Russia, Serenko O. A. ,   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia
Published: December 2024

Today, rubber crumb is used as the main component in the compositions for construction of soft road surfaces. This report presents the results of investigations on the mechanical properties of rubber–plastic composites containing 80 and 90 wt % of rubber crumb, based on different polyethylene matrices. It was established that, at high contents of rubber particles, there is no need to control the following characteristics of the matrix polymer to obtain the rubber–plastic composites deformable to at least 150%: the melt flow index, the content of HDPE or LDPE in the mixed matrix. The prospects for using the composites obtained were outlined.
Interannual variability modulates Harrison’s rule between cymothoid isopod and their prawn host: Insights from a long-term stream study
Authors: Wunderlich Alison , Mosna Esli , Pinheiro Marcelo
Published: December 2024

Host body size can influence the evolution of parasite body size in many host-parasite associations, a hypothesis called Harrison’s rule (HR). However, this pattern has not always been consistently observed, with some studies finding no association between host and parasite size. Moreover, other host-related factors (e.g., sex, immunity) and environmental changes can mediate this relationship. Here, we used a long-term dataset of cymothoid isopod-palaemonid prawn to test whether Harrison's rule applies to the relationship between host and parasite body traits (i.e., length, sex, weight), while accounting for the effect of seasons and years. Prawns were sampled seasonally over four years in a tropical stream in southeastern Brazil. We found a strong positive relationship between parasite and host body traits (i.e., length and weight), supporting Harrison’s rule. Our results further demonstrated that this relationship is independent of host sex and seasonal variation (i.e., dry and wet seasons) but is influenced by interannual variability. Host length and weight explained approximately 70% of the model variation, while interannual effects accounted for 30%. These highlight that the covariation between host and parasite body traits may be modulated by environmental changes, potentially altering Harrison's rule. Future research should consider interannual variability as a potentially critical factor driving host-parasite interactions and their evolutionary dynamics.
Advancements in Research on Non-AR- Signaling Pathways and Targeted Therapies for Castration-Resistant Prostate Cancer
Authors: Dad Haq , Hansen Asger
Published: December 2024

Prostate cancer (Pca) is a significant malignancy affecting men's health, with its incidence steadily increasing worldwide in recent years. Among its various subtypes, castration-resistant prostate cancer (CRPC) holds particular importance due to its pivotal role in the progression and management of Pca. The treatment options for Pca range from surgery to medication. However, the mechanisms underlying CRPC remain complex, with abnormal signal transduction pathways identified as a key factor in its development and progression. While the androgen receptor (AR) signaling pathway is widely recognized as central to CRPC pathogenesis, emerging research highlights the critical involvement of the non-AR signaling pathway in the disease. Prominent pathways in the disease include PI3K-Akt-mTOR, Wnt, Hippo, Hedgehog, Notch, HOXB13, and Jak2-Stat5a/b. Understanding the interplay between non-AR signaling pathways is vital for advancing therapeutic strategies for Pca. This work provides a comprehensive review of recent research progress on the relationship between non-AR signaling pathways and CRPC, aiming to offer insights and guidance for future research.
The Directions and Tools for Ensuring the Development of Agribusiness Based on the Introduction of Internet of Things Technologies
Authors:   Lviv University of Trade and Economics, Lupak Ruslan L. , Nakonechna Nataliya V. ,   Lviv Polytechnic National University
Published: December 2024

The article highlights the importance of active technologization and informatization of agricultural entrepreneurship, which not only affects its financial, economic and other results, but also determines the overall degree of food security of the national economy. The Internet of Things technology is considered from the point of view of its capabilities to comprehensively and systematically ensure the sequence of all vital operations in the agrarian sector, which provides for the formation of a closed production cycle and the introduction of agricultural products of high quality and innovativeness to the market. The main conclusions of the article relate to the establishment and expansion of the State support for agricultural entrepreneurship in the introduction of Internet of Things technologies, and according to this, the institutional and structural directions of the State policy and the corresponding tools for ensuring the development of the studied area are allocated. The article emphasizes the first-order significance of forming and improving the legislative and legal framework along with information and methodological support, the development of the institutional management system, the expansion of the spheres of cooperation and partnership of the agribusiness (institutional direction) and the strengthening of the orientation of the agribusiness to the establishment of new production of agricultural products of high added value and in-depth processing with a high level of quality and consumer characteristics, optimization of raw materials sources and their rational distribution (structural direction) in ensuring the development of agricultural entrepreneurship on the basis of the introduction of Internet of Things technologies. Priority is given to the processes of modernization of infrastructure support, elimination of legal restrictions, strengthening quality standards and monitoring and control of agricultural production processes, optimization of sources of resource provision, expansion of integration and cooperation relations, etc.
Decision Making in Small Business: The Behavioral Aspects
Authors:   V. N. Karazin Kharkiv National University, Merkulova Tamara V. , Maksymov Mykhailo S. ,   V. N. Karazin Kharkiv National University
Published: December 2024

Formally, the classification of business entities into small, medium and large businesses is carried out on the basis of quantitative criteria: production, the size of turnover and assets, the number of personnel, while they are quite similar in European countries. But quantitative indicators of business size determine a number of behavioral distinctive features of small and medium-sized businesses. The article, based on the methodology of behavioral economics, analyzes and systematizes the features of decision-making in such a form of business as small entrepreneurship. The following areas of decision-making in which they are manifested are allocated as follows: starting a business and the emergence of a business idea; aim and criteria for evaluating activities; business organization; methods and technologies of doing business. Deviations from the classical principles of rationality, such as profit maximization and optimization of activities, in decision-making in small business are analyzed. The hypothesis that the principle of profit maximization in small business management is replaced by the principle of sufficiency or satisfaction is substantiated. Orientation to traditions, proven recipes, common standards of behavior in doing business gives stability and viability to small business, but at the same time carries the threat of stagnation, consolidation of far from the best practices, rejection of innovations. In order to prevent such threats in work, using the conception of shocks, an approach to the formation of a decision-making model in small business, which is based on business frameworks, is proposed. Considering the framework as a kind of tool that simplifies the task and sets a certain algorithm of actions, the behavioral model can be presented as a set of frameworks that provides the possibility of using more productive approaches, requiring a lower level of cognitive load from its users. In this way, to a certain extent, the problem of resource and cognitive limitations, which are inherent in small business, is solved, and more effective decision-making is supported.
Risk Management of Financial Activities in the Construction Industry
Authors:   National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute», Kyrychenko Serhii О. , Katsevych Marta M. ,   National Technical University of Ukraine «Igor Sikorsky Kyiv Polytechnic Institute»
Published: December 2024

The article analyzes the financial risk management systems in the construction industry of Ukraine. The industry is characterized by high vulnerability to external economic and political factors, such as inflation, currency risks, instability of the macroeconomic environment and customer defaults. Over the past five years, the number of bankruptcies in the sector has increased by 15%, which indicates the need for effective risk management to ensure the financial stability of enterprises. The main risks faced by construction companies include market risks related to fluctuations in the prices of building materials (growth of 8% year-over-year), currency risks, credit risks, as well as liquidity risks due to delays in customer payments. The article examines the methods of risk assessment used in the field: VaR (method of statistical assessment of losses), stress testing, and scenario modeling. In addition, the implementation of modern management tools, such as BIM and ERP systems, is one of the key recommendations for improving the effectiveness of risk management. Such technologies allow companies to better control project processes, predict possible financial losses, and respond in a timely manner to changing conditions. The study also found that the existing risk management systems in Ukraine have significant shortcomings, including a low level of digitalization (only 25% of enterprises use modern risk management tools), lack of an integrated approach and insufficient legal protection. This is compared to international standards such as ISO 31000, which offers a system approach to risk management at all stages of the project. Only 15% of Ukrainian construction companies implement international standards in their risk management systems, which reflects the need to adapt these practices to increase the resilience of the industry. Macroeconomic factors, including inflation (average level in 2023: 12.9%) and currency fluctuations (the hryvnia exchange rate against the dollar has increased by 15% over the past five years), significantly affect the financial condition of construction companies. In addition, the cyclical nature of construction works creates additional risks, since the volume of construction activities varies depending on economic conditions. At the end of 2023, the volume of construction work in Ukraine increased by 22.6%, which indicates the recovery of the industry after crisis periods, but also emphasizes the importance of risk management in the face of economic fluctuations.
The Technical and Economic Indicators of Production of Synthetic Motor Fuels from Coal Depending on the Composition of Synthesis Gas and Economic Conditions
Authors:   Research Centre for Industrial Problems of Development of NAS of Ukraine, Kotliarov Yevhen I. , Shulha Ihor V. ,   Ukrainian State Research Institute for Carbochemistry (UKHIN), Kyzym Mykola O. ,   Research Centre for Industrial Problems of Development of NAS of Ukraine, Khaustova Viktoriia Ye. ,   Research Centre for Industrial Problems of Development of NAS of Ukraine
Published: December 2024

The production of synthetic motor fuels (SMF), which are an alternative to fuels of petroleum origin, is considered as an instrument for increasing the energy security of the State. The article is aimed at assessing the technical and economic indicators of organizing the production of SMF based on domestic coal and determining the conditions under which the relevant project will have investment attractiveness. As the main factors that ensure the efficiency of SMF production, the ratio of the amount of hydrogen and carbon monoxide in synthesis gas and the ratio of hard coal and crude oil prices (which determines the price of SMF) are considered. The uppermost efficiency of SMF production is achieved provided that the number of hydrogen molecules in the synthesis gas is at least 2 times higher than the number of carbon monoxide molecules. This is due to the composition of such fuel: a mixture of hydrocarbons with the generalized formula СnH2n and CnH2n+2, in the molecules of which the number of hydrogen atoms exceeds the number of carbon atoms by 2 times exactly. Gasification of hard coal does not allow obtaining synthesis gas of optimal composition, and therefore additional enrichment with hydrogen has been proposed. The proposed technical solution makes it possible to reduce the cost of coal for the production of SMF from 4.9 to 2.2 t/t. The performed calculations show that the profitability of operating activities is ensured with wide ranges of fluctuations in the price of coal ($100-200/t) and the price of crude oil (in the range of $70-140/barrel). However, when using credit resources for the implementation of the project, the discounted payback period can be provided in narrower ranges of price fluctuations for raw materials and finished products. Based on the calculations performed, a «line of indifference» is built, with the coordinates of the points corresponding to the level of coal and oil prices, according to which the discounted payback period will be 6.75 years after the enterprise is brought to the maximum use of production capacity.
The Role of Animal Husbandry in Ensuring Sustainable Development of the Agrarian Sector
Authors:   Branch Division «Vocational College of Oil and Gas Technologies, Engineering and Service Infrastructure of Odesa National Technological University», Glushkov Oleg A.
Published: December 2024

The article is devoted to the study of the role of animal husbandry in ensuring the sustainable development of the agrarian sector. The aim of the study is to determine the role of animal husbandry in ensuring the sustainable development of the agrarian sector by identifying key factors affecting its efficiency, ecological sustainability and socioeconomic significance. The article considers the current state, problems and prospects for the development of animal husbandry as a key branch of the agrarian sector, which ensures the economic stability of rural areas and food security of the country. The study provides an analysis of the main economic, environmental and social aspects of the functioning of the industry, in particular, the role of animal husbandry in providing the population with food products of high biological value and raw materials for industry. The study substantiates the need to integrate the principles of sustainable development into animal husbandry to overcome the challenges associated with environmental loads (greenhouse gas emissions, water pollution and soil degradation). Statistical data confirming the decline in the productivity of the industry and the decrease in the quality of livestock products in Ukraine are presented. In particular, a significant reduction in the number of cattle, a decrease in milk and wool production, as well as a shift in emphasis to the production of poultry meat were found. The study revealed the main problems hindering the development of the industry, such as low investments, lack of innovative technologies, outdated approaches to resource management and insufficient breeding work. Attention is also focused on the need to increase the competitiveness of the industry through the introduction of modern innovations, in particular the rational use of natural resources, organic animal husbandry and cost optimization. The study proposes strategic directions for the sustainable development of animal husbandry, which provide for ecological sustainability, economic efficiency and social responsibility. In particular, it is recommended to use technologies to reduce greenhouse gas emissions, introduce effective feed management models, develop organic production, stimulate investment and introduce innovative approaches to animal keeping. Animal husbandry is considered as a driver of economic growth of rural communities, capable of providing employment, increasing farmers’ incomes and contributing to the harmonious development of agroecosystems. Particular attention is paid to the role of biodiversity in agroecosystems, which supports the natural cycle of nutrients, pest control and adaptation to climate change.
Global Trends and Directions for the Development of Digital Innovations in the Payment Services Market
Authors:   Kyiv National Economic University named after Vadym Hetman, Kovalchuk Tamila H.
Published: December 2024

The article examines global trends and directions for the development of digital innovations in the payment services market; the main types of payment used in world payment systems and forming global trends and directions of development in the market of payment services are considered; the latest digital innovations used for efficient settlements in the modern world contributing to the further growth of the global payment market have been identified; the factors influencing the growth of digital payments are highlighted, their advantages and disadvantages are identified; privacy and security threats that can harm customers, businesses, markets and countries, as well as impede economic progress are considered; attention is drawn to the importance of effective market regulation and data protection laws. Based on the analysis of the main indicators of the dominant payment systems, the forecast of the use of these systems until 2027 is presented, special attention is paid to the financial services sector, which is slow to innovate in view of various problems and uses outdated payment systems; the effective use of the latest payment systems in this field of activity is substantiated. The current state of development of payment systems in Ukraine is highlighted; the legislative framework that guarantees the clear, reliable, responsible operation of payment systems and contributes to the development of the economy is considered; the most important payment systems in the country are presented and their activities are analyzed; the development of the Ukrainian payment infrastructure, despite hostilities and restrictions, is substantiated; the main strategic trends in the development of payment systems in Ukraine are identified, suggesting some improvements of payment infrastructure, introduction of the latest technologies such as mobile payments and blockchain, also ensuring a high level of security and protection of users’ personal data, taking into account new changes aimed at improving security, inclusiveness, convenience, the use of artificial intelligence and the introduction of a central bank digital currency, and the regulation of the crypto-asset market, which is typical for the development of payment systems of any country in the digital technologies era.
Methodological Approach to Assessing the Level of Innovative Business Development
Authors:   V. N. Karazin Kharkiv National University, Denchyk Iryna S.
Published: December 2024

The article surveys a methodological approach to assessing the level of innovative business development in the context of the digital transformation of the economy. Particular attention is paid to the formation of the innovative potential of enterprises, which is the basis for increasing their competitiveness and sustainability in the context of globalization and dynamic market changes. The author proposes a comprehensive algorithm for assessing innovation potential based on the use of the Innovation Scorecard system to determine the level of innovation, as well as to assess individual components of innovation development, such as information, scientific, technical, financial, and human resources potential. The article examines the key factors that determine the success of an enterprise's innovation activity, including organizational and management mechanisms, strategic planning, flexibility of adaptation to digital changes, and the use of the latest technologies in business processes. In addition, the article analyzes the impact of corporate culture on the innovative maturity of enterprises and also considers the importance of implementing standards of innovation management and effective management of social security in business. It is shown that the introduction of innovative approaches allows enterprises not only to increase productivity but also to function sustainably in a changing environment, achieving long-term success. The presented results of the study can be used to develop strategies for innovative development aimed at improving economic efficiency and reducing risks in the process of enterprises' adaptation to the digital economy. The conclusions are of practical importance for scientists, managers and policy makers who are interested in developing effective mechanisms to support innovation in the current conditions of digital transformation.
Edukasi Ibu Balita dalam Pemanfaatan Daun Kelor sebagai Sumber Nutrisi Pencegahan Stunting
Authors: Elmiyanti Ni Ketut , Salamung Niswa , Purwaningsih Diah Fitri , Wahyu Wahyu
Published: December 2024

ABSTRAK Stunting masih menjadi masalah kesehatan di Indonesia. Anak yang menderita Stunting akan kesulitan untuk mencapai tinggi badan optimal dan terjadi peningkatan angka kesaitan serta kematian. Desa Lebanu kabupaten Sigi merupakan wilayah dengan angka stunting tertinggi di provinsi Sulawesi Tengah, sehingga perlu adanya intervensi yang tepat untuk dapat menyelesaikan masalah ini. Salah Satu faktor yang dapat menyebabkan terjadinya stunting pada anak adalah pengetahuan ibu yang kurang dalam peberian makanan bergizi pada anak. Edukasi perlu diberikan kepada ibu balita hingga mereka mamahami dan dapat memberikan makanan bergizi bagi anak. Edukasi pada ibu balita diharapkan dapat meningkatkan pengetahuan dalam memanfaatkan daun kelor sebagai sumber nutrisi. Melalui penyuluhan tentang pemanfaatan daun kelor sebagai sumber nutrisi pencegahan stunting dan penilaian kemampuan pengetahuan dengan cara pre post test. Adanya perubahan pengetahuan ibu balita tentang pemanfaatan daun kelor sebagai sumber nutrisi pencegahan stunting dimana saat pretest hanya 25% ibu yang memiliki pengetahuan baik dan meningkat menjadi 91,6 % setelah diberikan penyuluhan. Terdapat peningkatan pengetahuan ibu balita dalam pemanfaatan daun kelor sebagai nutrisi pencegahan stunting. Kata Kunci: Edukasi, Stunting, Ibu, Kelor  ABSTRACT Stunting is still a health problem in Indonesia. Children who suffer from stunting will find it difficult to reach optimal height and there will be an increase in morbidity and mortality. Lebanu village, Sigi district, is the area with the highest stunting rate in Central Sulawesi province, so there needs to be appropriate intervention to solve this problem. One of the factors that can cause stunting in children is mothers' lack of knowledge in providing nutritious food to children. Education needs to be given to mothers of toddlers so that they understand and can provide nutritious food for their children. Education for mothers of toddlers is expected to increase knowledge in using Moringa leaves as a source of nutrition. Through counseling about the use of Moringa leaves as a source of nutrition to prevent stunting and assessing knowledge skills using a pre-post test. There was a change in the knowledge of mothers of toddlers regarding the use of Moringa leaves as a source of nutrition to prevent stunting where at pretest only 25% of mothers had good knowledge and this increased to 91.6% after being given counseling. There is an increase in the knowledge of mothers of toddlers regarding the use of Moringa leaves as nutrition to prevent stunting. Keywords: Education, Stunting, mother, Moringa
Peningkatan Pemahaman Fear of Missing Out (FoMO) pada Remaja Dalam Aktifitas Media Sosial
Authors: Dewi Heni Aguspita , Lutfi Baharudin , Sulastri Meti , Hidayatuloh Ana Ikhsan , Hilmawan Rikky Gita , Marlina Lina , Daryanti Eneng , Wahyudi Deni , Amalia Novianti Rizki , Mulyana Hilman , Mulyana Asep , Hayati Euis Teti , Vansugist Mamay , Lestari Sri , Apriliani Silvia Sri
Published: December 2024

ABSTRAK Remaja adalah pengguna media sosial tertinggi, tingginya pengunaan media sosial membuat remaja rentan mengalami Fear of Missing Out (FoMO). Pengabdian dilakukan untuk mengetahui gambaran pemahaman FoMO sebelum dan setelah dilakukan pengabdian masyarakat. Jumlah responden 357 siswa dari SMPN 5 Kota Tasikmalaya dan SMPN 1 Cikoneng Ciamis, terdapat sekitar 700 peserta yang yang yang mengikuti kegiatan pengmas. Dilakukan penilaian pemahaman FoMO sebelum dan setelah dilakukan penyuluhan dengan menyebarkan kuesioner. Pemahaman FoMO sebelum dilakukan penyuluhan pada remaja di SMPN 5 Kota Tasikmalaya dan SMPN 1 Cikoneng Ciamis sebagian besar berada pada kategori kurang sebesar 53,8%. Setelah dilakukan penyuluhan pemahaman FoMO sebagian besar berada pada kategori baik sebesar 37,8%. penyuluhan yang dilakukan melalui pengabdian Masyarakat terbukti dapat meningkatkan pemahaman FoMO pada remaja. Disarankan untuk dapat melakukan kegiatan pengebdian Masyarakat lanjutan agar dapat mengatasi masalah Fear of Missing Out (FoMO) pada remaja. Kata Kunci: Fear of Missing Out (FoMO), Pemahaman, Remaja  ABSTRACT Teenagers are the highest users of social media, the high use of social media makes teenagers vulnerable to experiencing Fear of Missing Out (FoMO). The service was carried out to find an overview of understanding FoMO before and after community service. The number of respondents was 357 students from SMPN 5 Kota Tasikmalaya and SMPN 1 Cikoneng Ciamis, the participants who took part in community service activities numbered around 700 people. Assessment of understanding of FoMO was carried out before and after the counseling by distributing questionnaires. Understanding of FoMO before counseling was carried out among teenagers at SMPN 5 Kota Tasikmalaya and SMPN 1 Cikoneng Ciamis was mostly in the poor category at 53.8%. After counseling, understanding of FoMO was mostly in the good category at 37.8%. Counseling carried out through community service has been proven to increase understanding of FoMO in adolescents. It is recommended to carry out further community service activities to overcome the problem of Fear of Missing Out (FoMO) in teenagers.  Keywords: Fear of Missing Out (FoMO), Understanding, Teenagers
Penyuluhan dan Simulasi Bantuan Hidup Dasar pada Siswa/I SMA Swasta Bukit Cahaya Huta Manik Kecamatan Sumbul
Authors: Manik Herlina Evi Yanti , Togianur Rugun , Simangunsong Dame Evalina
Published: December 2024

ABSTRAK Pengabdian kepada masyarakat Prodi DIII Keperawatan Dairi  Poltekkes Kemenkes Medan dilakukan dalam bentuk Penyuluhan dan Simulasi Bantuan Hidup Dasar  Pada Siswa/I SMA Swasta Bukit Cahaya Huta Manik Kecamatan Sumbul Tahun 2024. Lokasi pengabadian masyarakat adalah Siswa/I SMA Swasta Bukit Cahaya Huta Manik Kecamatan Sumbul Tahun 2024 berjumlah 100 orang. Tujuan Pengabdian Kepada Masyarakat ini adalah untuk mewujudkan pengabdian kepada masyarakat sebagai salah satu kegiatan Tri Darma Perguruan Tinggi, meningkatkan pengetahuan dan keterampilan Siswa/I SMA Swasta Bukit Cahaya Huta Manik mengenai bantuan hidup dasar. Salah satu upaya untuk meningkatkan pengetahuan dan keterampilan bantuan hidup dasar adalah dengan  penyuluhan dan simulasi bantuan hidup dasar. Metode yang digunakan dalam kegiatan Pengabdian Masyarakat ini adalah edukasi : ceramah dan diskusi, melakukan simulasi dan sekaligus demonstrasi tentang bantuan hidup dasar. Hasil pengabdian kepada siswa  diperoleh pengetahuan  pre test baik 32%, cukup 19 %, kurang 49%. Setelah diberikan penyuluhan diperoleh 49 % pengetahuan baik dan 51% pengetahuan cukup. Pre test keterampilan diperoleh keterampilan cukup 25 % dan 75% kurang. Setelah diberikan simulasi diperoleh keterampilan 35 % baik dan 65% keterampilan cukup.      Kata Kunci: Penyuluhan, Simulasi , Bantuan Hidup Dasar, Siswa   ABSTRACT Community service for the DIII Nursing Study Program, Dairi Health Polytechnic, Ministry of Health, Medan, was carried out in the form of counseling and basic life support simulations for students of Bukit Cahaya Huta Manik Private High School, Sumbul District in 2024. The location of community service was students of Bukit Cahaya Huta Manik Private High School, Sumbul District. In 2024 there will be 100 people. The aim of this Community Service is to realize community service as one of the Tri Dharma of Higher Education activities, increasing the knowledge and skills of students at Bukit Cahaya Huta Manik Private High School regarding basic life support.  One effort to improve basic life support knowledge and skills is through basic life support counseling and simulations. The method used in this Community Service activity is education: lectures and discussions, carrying out simulations and at the same time demonstrating basic life support. The results of the service to students obtained pre-test knowledge of 32% good, 19% sufficient, 49% poor. After being given counseling, 49% had good knowledge and 51% had sufficient knowledge. Pre test skills obtained 25% sufficient skills and 75% less. After being given the simulation, 35% of the skills were good and 65% of the skills were sufficient. Keywords: Counseling, Simulation, Basic Life Support, Students
Edukasi Perawatan Gigi dan PHBS pada Anak-Anak Usia Dini (Paud) di Desa Jelegong, Kecamatan Rancaekek
Authors: Mardhiyah Ai , Eriyani Theresia , Maryam Nenden Nur Asriyani , Yudianto Kurniawan , Rukmasari Ema Arum
Published: December 2024

ABSTRAK Stunting merupakan keadaan umum dari bentuk kekurangan gizi (PE/mikronutrien), yang mempengaruhi bayi sebelum lahir dan awal setelah lahir, terkait dengan ukuran ibu, gizi selama ibu hamil, dan pertumbuhan janin. Selain itu, stunting yang dialami balita juga merupakan salah satu tanda gizi kronis yang dapat memberikan gambaran gangguan keadaan sosial ekonomi secara keseluruhan di masa lampau dan dampak yang sulit diperbaiki pada 2 tahun awal kehidupan. Meningkatkan pemahaman dalam upaya pembiasaan PHBS dan kebersihan gigi yang benar sebagai pencegahan stunting. Penelitian ini menggunakan metode penyuluhan dan sosialisasi dengan tahapan demonstrasi, lagu dan permainan, media edukasi, dan tanya jawab serta diskusi. Terdapat peningkatan pengetahuan pada siswa dan orang tua yang dilihat dari peningkatan nilai dari pre-test dan post-test. Data menunjukkan bahwa pengetahuan peserta, seperti orang tua dan siswa PAUD mengenai topik tersebut sebelum dan sesudah mengikuti penyuluhan mengalami peningkatan. Dengan meningkatnya pengetahuan para peserta, terutama orang tua yang menjadi agen perubahan, diharapkan dapat menurunkan angka stunting di desa tersebut. Kata Kunci: Perawatan Gigi, PHBS, Stunting  ABSTRACT Stunting is a common condition of malnutrition (PE/micronutrients) that affects infants before and shortly after birth, related to the mother's size, nutrition during pregnancy, and fetal growth. In addition, stunting experienced by toddlers is also a sign of chronic malnutrition that can reflect the overall socioeconomic disturbances of the past and the difficult-to-repair impacts during the first two years of life. To enhance understanding in the efforts of habituating PHBS (Clean and Healthy Behavior) and proper dental hygiene as a prevention of stunting. This study uses a method of outreach and socialization with stages of demonstration, songs and games, educational media, as well as question and answer sessions and discussions. There is an increase in knowledge among students and parents, as evidenced by the improvement in scores from the pre-test to the post-test. The data shows that the knowledge of participants, such as parents and early childhood education students, regarding the topic increased before and after attending the counseling session. With the increasing knowledge of the participants, especially the parents who become agents of change, it is hoped that the stunting rate in the village can be reduced. Keywords: Dental Care, Healthy Lifestyle Behavior, Stunting
预见性护理预防颅脑肿瘤患者围手术期压疮的效果评价
Authors: 李 欢欢 , 范 小影 , 王 馨若 , 张 微
Published: December 2024

目的：探究预见性护理预防颅脑肿瘤患者围手术期压疮的效果；方法：选取2023年1月～2023年12月我院收治的122例颅脑肿瘤患者作为本次研究对象，按照随机数字表法将其分为对照组和观察组，每组各61例，给予对照组常规护理，给予观察组预见性护理，观察两组患者的护理效果；结果：观察组护理效果明显优于对照组（P＜0.05）；结论：为了有效预防颅脑肿瘤患者围手术期压疮，可采取预见性护理对其实施干预。
龙胆泻肝汤配合针灸在治疗突发性肝胆火盛型耳聋的疗效观察
Authors: 卞 秦
Published: December 2024

目的：观察龙胆泻肝汤配合针灸在治疗突发性肝胆火盛型耳聋的疗效。方法：选取2023年1月～2024年2月本院收治的60例突发性肝胆火盛型耳聋患者，按照治疗方法不同随机分为观察组与参照组，比较疗效。结果：观察组治疗有效率高于参照组（P＜0.05）；观察组治疗后耳鸣耳聋、头痛面赤、口苦咽干、心烦易怒评分均低于参照组（P＜0.05）；观察组治疗后各项免疫功能指标低于参照组（P＜0.05）。结论：龙胆泻肝汤配合针灸治疗突发性肝胆火盛型耳聋有很好的效果，可有效改善症状，还能调理气血，调整免疫功能，值得推广应用。