bluuebunny/crossref_metadata_2025 huggingface dataset:
Subclinical Ocular Changes after Intravitreal Injections of Different Anti-VEGF Agents for Neovascular Age-Related Macular Degeneration
Authors: Matsubara Hisashi , Nagashima Ryunosuke , Chujo Shinichiro , Matsui Yoshitsugu , Kato Kumiko , Kuze Manami , Kondo Mineo
Published: November 2023

Intraocular inflammations (IOIs) have been reported to occur after intravitreal injections of brolucizumab, and one of their causes has been suggested to be drug-specific features. We evaluated the anterior chamber by the aqueous flare value (AFV) and the retina by flicker electroretinography (ERG) after the initial intravitreal injection of aflibercept (IVA), brolucizumab (IVBr), or faricimab (IVF) for neovascular age-related macular degeneration (nAMD). The AFV and flicker ERGs were determined before, 2 weeks after, and 4 weeks after the injections in 14 eyes of 14 patients for each drug. After the injections, none of the patients had an IOI, but the AFV increased significantly in the IVA and IVF groups. The increase in the IVF group was +4.6 photon count/ms, which was significantly greater than in the other groups, but was not clinically significant. The implicit time was significantly prolonged in the IVBr group but unchanged in the IVA and IVF groups. These results suggest that brolucizumab, administered at high molar doses, may cause transient retinal disturbances that are not detectable by general ophthalmologic examinations but affect the implicit ERG times.
Characteristics and Outcome Analysis for Intensive Care Patients Undergoing Decompressive Laparotomy for Abdominal Compartment Syndrome: Impact of Extracorporeal Membrane Oxygenation Support
Authors: Nitschke Christine , Schulte Marco , Izbicki Jakob R. , Hackert Thilo , Kluge Stefan , Burdelski Christoph , Bachmann Kai
Published: November 2023

(1) Background: Abdominal compartment syndrome (ACS) is a life-threatening situation and is associated with high mortality in the intensive care unit (ICU). Decompressive laparotomy represents the last therapeutic option. This cohort study aims to optimize the selection of ICU patients suffering from ACS who benefit from decompressive laparotomy. (2) Methods: All available data from adult patients treated at the 12 ICUs of a university hospital between 2011 and 2019 were included. Outcome parameters for patients with and without extracorporeal membrane oxygenation (ECMO) were compared. (3) Results: 207 ICU patients with ACS undergoing surgery were identified. Laparotomy resulted in immediate improvement of organ functions in 15% of patients, who then survived more frequently. The overall mortality rate in our cohort was 69%. The group of ECMO patients—including va- and vv-ECMO—showed significantly less organ function improvement and a higher mortality rate of 79% compared to a better postoperative improvement and a lower mortality rate of 62% in non-ECMO patients. (4) Conclusions: There are ICU patients who benefit from decompressive laparotomy—nevertheless, mortality is high. Non-ECMO patients have a better prognosis than ECMO patients. Our findings can support clinical decision-making on emergency surgery and the development of future guidelines.
Characterizing Movement Patterns of Older Individuals with T2D in Free-Living Environments Using Wearable Accelerometers
Authors: Yahalom-Peri Tal , Bogina Veronika , Basson-Shleymovich Yamit , Azmon Michal , Kuflik Tsvi , Kodesh Einat , Volpato Stefano , Cukierman-Yaffe Tali
Published: November 2023

(1) Background: Type 2 Diabetes (T2D) is associated with reduced muscle mass, strength, and function, leading to frailty. This study aims to analyze the movement patterns (MPs) of older individuals with T2D across varying levels of physical capacity (PC). (2) Methods: A cross-sectional study was conducted among individuals aged 60 or older with T2D. Participants (n = 103) were equipped with a blinded continuous glucose monitoring (CGM) system and an activity monitoring device for one week. PC tests were performed at the beginning and end of the week, and participants were categorized into three groups: low PC (LPC), medium PC (MPC), and normal PC (NPC). Group differences in MPs and physical activity were analyzed using non-parametric Kruskal–Wallis tests for both categorical and continuous variables. Dunn post-hoc statistical tests were subsequently carried out for pairwise comparisons. For data analysis, we utilized pandas, a Python-based data analysis tool, and conducted the statistical analyses using the scipy.stats package in Python. The significance level was set at p < 0.05. (3) Results: Participants in the LPC group showed lower medio-lateral acceleration and higher vertical and antero-posterior acceleration compared to the NPC group. LPC participants also had higher root mean square values (1.017 m/s2). Moreover, the LPC group spent less time performing in moderate to vigorous physical activity (MVPA) and had fewer daily steps than the MPC and NPC groups. (4) Conclusions: The LPC group exhibited distinct movement patterns and lower activity levels compared to the NPC group. This study is the first to characterize the MPs of older individuals with T2D in their free-living environment. Several accelerometer-derived features were identified that could differentiate between PC groups. This novel approach offers a manpower-free alternative to identify physical deterioration and detect low PC in individuals with T2D based on real free-living physical behavior.
Patient-Related Factors Associated with Adverse Outcomes Following Weaning from Veno-Arterial Extracorporeal Membrane Oxygenation
Authors: Keller Marius , Gloeckner Henning , Sari-Yavuz Sibel , Haeberle Helene A. , Schlensak Christian , Rosenberger Peter , Magunia Harry , Koeppen Michael
Published: November 2023

Background: Veno-arterial extracorporeal membrane oxygenation (vaECMO) removal reflects a critical moment and factors of adverse outcomes are incompletely understood. Thus, we studied various patient-related factors during vaECMO removal to determine their association with outcomes. Methods: A total of 58 patients from a university hospital were included retrospectively. Demographic, clinical, and echocardiographic parameters were recorded while under vaECMO support, as well as the need for inotropic and vasoactive-inotropic scores (VIS). Successful weaning was defined as 28-day survival without reinitiation of vaECMO. Results: Patient age differed significantly between patients with a successful and a failed vaECMO weaning (54 ± 14 vs. 62 ± 12 years, p = 0.029). In univariable logistic regression, age (OR 0.952 (0.909–0.997), p = 0.038), the necessities for inotropic agents at the time of echocardiography (OR 0.333 (0.113–0.981), p = 0.046), and vaECMO removal (OR 0.266 (0.081–0.877), p = 0.030) as well as the dobutamine dose during removal (OR 0.649 (0.473–0.890), p = 0.007), were significantly associated with a successful weaning from vaECMO. Age (HR 1.048 (1.006–1.091), p = 0.024) and the VIS (HR 1.030 (1.004–1.056), p = 0.025) at the time of vaECMO removal were independently associated with survival in bivariable Cox regression. In Kaplan–Meier analysis, a VIS of >5.1 at vaECMO removal was associated with impaired survival (log-rank p = 0.025). Conclusions: In this cohort, age and the extent of vasoactive-inotropic agents were associated with adverse outcomes following vaECMO, whereas echocardiographic biventricular function during vaECMO support was not.
Evaluation of Real-Time Intracochlear Electrocochleography for Guiding Cochlear Implant Electrode Array Position
Authors: Scheperle Rachel , Etler Christine , Oleson Jacob , Dunn Camille , Kashani Rustin , Claussen Alexander , Gantz Bruce J. , Hansen Marlan R.
Published: November 2023

This study evaluates intracochlear electrocochleography (ECochG) for real-time monitoring during cochlear implantation. One aim tested whether adjusting the recording electrode site would help differentiate between atraumatic and traumatic ECochG amplitude decrements. A second aim assessed whether associations between ECochG amplitude decrements and post-operative hearing loss were weaker when considering hearing sensitivity at the ECochG stimulus frequency compared to a broader frequency range. Eleven adult cochlear implant recipients who were candidates for electro-acoustic stimulation participated. Single-frequency (500-Hz) ECochG was performed during cochlear implantation; the amplitude of the first harmonic of the difference waveform was considered. Post-operative hearing preservation at 500 Hz ranged from 0 to 94%. The expected relationship between ECochG amplitude decrements and hearing preservation was observed, though the trend was not statistically significant, and predictions were grossly inaccurate for two participants. Associations did not improve when considering alternative recording sites or hearing sensitivity two octaves above the ECochG stimulus frequency. Intracochlear location of a moving recording electrode is a known confound to real-time interpretation of ECochG amplitude fluctuations, which was illustrated by the strength of the correlation with ECochG amplitude decrements. Multiple factors contribute to ECochG amplitude patterns and to hearing preservation; these results highlight the confounding influence of intracochlear recording electrode location on the ECochG.
Tacrolimus as a Promising Drug for Epistaxis and Gastrointestinal Bleeding in HHT
Authors: Álvarez-Hernández Paloma , Patier José Luis , Marcos Sol , Gómez del Olmo Vicente , Lorente-Herraiz Laura , Recio-Poveda Lucía , Botella Luisa María , Viteri-Noël Adrián , Albiñana Virginia
Published: November 2023

Background: Hereditary Hemorrhagic Telangiectasia (HHT) is a vascular autosomically inherited rare disease. Epistaxis (nose bleeds) is the most common symptom in HHT, leading to anemia and affecting the patient’s quality of life. In addition to epistaxis, gastrointestinal bleeding (GI), more often at older ages, may lead to severe anemia and the need for blood transfusions. Thus, finding drugs to control both types of bleeding is a primary necessity in HHT. Methods: A cross-sectional observational study was conducted in a series of 11 HHT patients treated with low tacrolimus doses (0.5–2 mg/day) on an off-label prescription basis. Patients showed refractory bleeding to previous treatments. The epistaxis severity score (ESS) and hemoglobin levels were the parameters used to evaluate the impact of tacrolimus. The occurrence of side effects was also recorded. Results: Tacrolimus was well tolerated in all of the patients except 2 (who stopped the treatment). The remaining patients tolerated the treatment, with a general improvement in their health condition. Epistaxis was significantly reduced when comparing the ESS before and after the treatment. Hemoglobin levels significantly increased, overcoming the anemia, during the course of the treatment. Conclusion: Tacrolimus at low doses should be considered as a promising treatment for epistaxis and gastrointestinal bleeding in HHT.
Post-Stroke Brain Health Monitoring and Optimization: A Narrative Review
Authors: Stulberg Eric L. , Sachdev Perminder S. , Murray Anne M. , Cramer Steven C. , Sorond Farzaneh A. , Lakshminarayan Kamakshi , Sabayan Behnam
Published: November 2023

Significant advancements have been made in recent years in the acute treatment and secondary prevention of stroke. However, a large proportion of stroke survivors will go on to have enduring physical, cognitive, and psychological disabilities from suboptimal post-stroke brain health. Impaired brain health following stroke thus warrants increased attention from clinicians and researchers alike. In this narrative review based on an open timeframe search of the PubMed, Scopus, and Web of Science databases, we define post-stroke brain health and appraise the body of research focused on modifiable vascular, lifestyle, and psychosocial factors for optimizing post-stroke brain health. In addition, we make clinical recommendations for the monitoring and management of post-stroke brain health at major post-stroke transition points centered on four key intertwined domains: cognition, psychosocial health, physical functioning, and global vascular health. Finally, we discuss potential future work in the field of post-stroke brain health, including the use of remote monitoring and interventions, neuromodulation, multi-morbidity interventions, enriched environments, and the need to address inequities in post-stroke brain health. As post-stroke brain health is a relatively new, rapidly evolving, and broad clinical and research field, this narrative review aims to identify and summarize the evidence base to help clinicians and researchers tailor their own approach to integrating post-stroke brain health into their practices.
Influence of Shortened Tongue Frenulum on Tongue Mobility, Speech and Occlusion
Authors: Dydyk Aldona , Milona Marta , Janiszewska-Olszowska Joanna , Wyganowska Marzena , Grocholewicz Katarzyna
Published: November 2023

(1) Background: The incidence of ankyloglossia is 0.02–10.7%. Its effect on selected dysfunctions has been described; however, no studies report its impact on several disorders in a group of subjects. The aim of this study was to assess the effect of ankyloglossia on swallowing, speech, occlusion and periodontium. (2) Methods: The study group consisted of 86 patients with ankyloglossia, and the control group (n = 86) had a normal tongue frenulum. Type of swallowing, tongue mobility, speech, occlusion and periodontium were assessed. (3) Results: Ankyloglossia pertained to 75.6% patients with infantile swallowing and 41.3% patients with mature swallowing. Limited tongue mobility was found in 29.4% subjects with moderate ankyloglossia and 70.6% subjects with severe ankyloglossia. All subjects with mild ankyloglossia and all the controls had normal tongue mobility. The relationship between dysglossia and ankyloglossia severity was statistically significant. Malocclusion or crowding was diagnosed in 62% subjects with ankyloglossia and 21.6% subjects in the control group. No periodontal abnormalities were found in any subject. (4) Conclusions: (1) A short tongue frenulum negatively influences swallowing and is associated with an “infantile swallowing pattern”. (2) Moderate or severe ankyloglossia significantly limits tongue mobility. (3) A short tongue frenulum negatively influences speech. (4) Ankyloglossia is associated with higher prevalence of malocclusion.
Titanium Biohybrid Middle Ear Prostheses: A Preliminary In Vitro Study
Authors: Mosconi Mario , Carlotto Elena , Caliogna Laura , Berni Micaela , Gastaldi Giulia , Conti Michele , Brancato Alice Maria , Bina Valentina , Minervini Domenico , Malpede Stefano , Stellato Anna Chiara , Lazzerini Francesco , Bruschini Luca , Benazzo Marco , Canzi Pietro
Published: November 2023

Ossiculoplasty is a surgical operation performed to restore auditory transmission through the reconstruction of the ossicular chain using prosthetics. Tissue bioengineering has assumed a pivotal role in implementing alternatives to conventional ossicular middle ear replacement prostheses, to overcome extrusion while preserving acoustic properties. This in vitro study aims to explore, for the first time in current literature, the feasibility of a biohybrid middle ear prosthesis, composed of titanium surrounded by a bone extracellular matrix as bio-coating. We have hereby studied the adhesion and proliferation of human adipose-derived mesenchymal stem cells (hASC) on titanium scaffolds in vitro. Moreover, we identified the osteogenic differentiation of hASC using an immunofluorescence assay to analyze osteoblasts’ gene expression profiles (Alp, Runx2, Col1a1, Osx, and Bglap), and we counted the presence of collagen as a marker of hASC’s ability to secrete an extracellular matrix. We utilized scanning electron microscopy to evaluate the presence of an extracellular matrix on the scaffolds. Our preliminary data demonstrated the titanium’s ability to support human adipose-derived mesenchymal stem cell colonization, proliferation, and osteoblastic differentiation, in order to obtain a biohybrid device. Our experience seems encouraging; thus, we advocate for further in vivo research to corroborate our results regarding bone transplantation.
A Global-Ocean-Data Assimilation for Operational Oceanography
Authors: Qin Yinghao , Yu Qinglong , Wan Liying , Liu Yang , Mo Huier , Wang Yi , Meng Sujing , Wu Xiangyu , Sui Dandan , Xie Jiping
Published: November 2023

In this study, a global-ocean-data-assimilation system based on the three-dimensional variational (3DVAR) scheme is built for operational oceanography. The available observations include satellite altimetry; the satellite-measured sea-surface temperature (SST); and T/S profiles from Argo floats, which are assimilated to provide the initial condition of the global-ocean forecasting. The statistical analysis methods are designed to assess the performance of the data-assimilation scheme, and the results show that the analysis SST fields agree well with OSTIA and MGDSST, and the corresponding root-mean-square errors are, respectively, 0.523 and 0.548 °C. Moreover, the analysis sea-surface-height fields are well represented at the middle and low latitudes and have a slightly greater difference in the regions with strong mesoscale eddies. The variations in the vertical distribution of the forecasting temperature profiles resemble those of the GTS buoy observation. The forecasting salinity profiles correspond well to GTS observations, except with a weaker cold bias between the depths 100 and 200 m (about 0.2 PSU) at buoy station 2901494. Overall, our 3DVAR assimilation system plays a significant role in improving the accuracy of analysis and forecasting fields for operational oceanography.
Study on Meso-Structural Evolution of Bedrock Beneath Offshore Wind Turbine Foundation in Pressurized Seawater
Authors: Zhang Qi , Zhang Chenhao , Lin Yifeng , Li Yuanhai , Shen Yixin , Pei Yuechao
Published: November 2023

In recent years, offshore wind turbine technology has been widely developed, making a significant contribution to the advancement of renewable energy. Due to the predominant subsurface geological composition characterized by rocky formations in some marine areas, rock-socketed piles are commonly applied as offshore wind turbine foundations. Generally, rock-socketed piles need to be driven into rock layers that have not undergone significant weathering or erosion for optimal load-bearing capacity. This design is essential to ensure structural support for offshore wind turbines. However, during the long-term operation period of offshore wind turbines, the contact surface between the rock-socketed pile and the rock is prone to be detached under multiple dynamic loads. The generated channel makes seawater seep into the unweathered rock layer, resulting in the erosion of rock meso-structure and deterioration of mechanical properties. The reduced load-bearing capacity will adversely affect the operation of the offshore wind turbine. In this study, the meso-structural evolution of bedrock in pressurized seawater is investigated by X-ray CT imaging using tuff samples from the marine areas of an offshore wind farm in China. A cellular automata model is proposed to predict the long-term evolutionary process of tuff meso-structure. Results indicate that the porosity of the tuff sample in the pressurized seawater shows an upward trend over time. Based on the erosion rate of pores obtained from the CT scanning test, the proposed cellular automata model can predict the evolutionary process of tuff meso-structure and corresponding failure strength of the bedrock in the long term.
Annular Electromagnetic Generator for Harvesting Ocean Wave Energy
Authors: Wang Chunjie , Guo Linghao , Chen Peng , Fu Qiang , Cui Lin
Published: November 2023

To sustainably power ocean sensors by harvesting ocean wave energy, an annular electromagnetic generator (A-EMG) based on the principle of Faraday electromagnetic induction is proposed in this paper. The specific structure and working principle of the generator are introduced. The distribution of the magnetic field in the coil, the variation in the induced voltage and the influence of the coil parameters on the output were simulated by the COMSOL Multiphysics software version 6.0. At the same time, an experimental platform was built to test the output characteristics of the generator. Through a comparative study of the capacitor’s charging characteristics, the optimal connection mode between the multiple groups of coils of the generator was preliminarily verified. Finally, the six-degree-of-freedom (6-DOF) platform was used to simulate various wave motion parameters, and the feasibility of the generator for supplying power to ocean sensors was verified.
Changes in the Liver Transplant Waiting List after Expanding to the ‘Up-to-Seven’ Criteria for Hepatocellular Carcinoma
Authors: Zamora-Olaya Javier Manuel , Aparicio-Serrano Ana , Amado Torres Víctor , Poyato González Antonio , Montero José Luis , Barrera Baena Pilar , Sánchez Frías Marina , Ciria Bru Rubén , Briceño Delgado Javier , De la Mata Manuel , Rodríguez-Perálvarez Manuel
Published: November 2023

We aimed to assess changes in the composition of the waiting list for liver transplantation (LT) after expanding from Milan to “up-to-seven” criteria in patients with hepatocellular carcinoma (HCC). A consecutive cohort of 255 LT candidates was stratified in a pre-expansion era (2016–2018; n = 149) and a post-expansion era (2019–2021; n = 106). The most frequent indication for LT was HCC in both groups (47.7% vs. 43.4%; p = 0.5). The proportion of patients exceeding the Milan criteria in the explanted liver was nearly doubled after expansion (12.5% vs. 21.1%; p = 0.25). Expanding criteria had no effect in drop-out (12.3% vs. 20.4%; p = 0.23) or microvascular invasion rates (37.8% vs. 38.7%; p = 0.93). The length on the waiting list did not increase after the expansion (172 days [IQR 74–282] vs. 118 days [IQR 67–251]; p = 0.135) and was even shortened in the post-expansion HCC subcohort (181 days [IQR 125–232] vs. 116 days [IQR 74–224]; p = 0.04). Tumor recurrence rates were reduced in the post-expansion cohort (15.4% vs. 0%; p = 0.012). In conclusion, expanding from Milan to up-to-seven criteria for LT in patients with HCC had no meaningful impact on the waiting list length and composition, thus offering the opportunity for the adoption of more liberal policies in the future.
Detection of Construction and Demolition Illegal Waste Using Photointerpretation of DEM Models of LiDAR Data
Authors: Sánchez-Fernández Manuel , Arenas-García Lorea , Gutiérrez Gallego José Antonio
Published: November 2023

Illegal waste is a global problem with negative impacts on human health and the environment. This article focuses on detection using remote sensing of sites of demolition and construction waste. We hypothesise that construction and demolition waste represent a human modification of terrain and, as a result, will be sensible to detection using visualisation models of terrain, specifically DEM (digital elevation model). To this effect, we start with a DEM of 0.25 m per pixel developed using data from the second iteration of the PNOA LiDAR project by the Spanish National Geographic Institute (IGN). We evaluate seven modelling tools of the Relief Visualisation Toolbox (RVT) for the visual detection of waste. The study area includes the city of Mérida (Extremadura, Spain). Our fieldwork identified 494 points of illegal waste in this area. These points were classified according to five categories in relation to land use, and we established a total of 14 areas with a surface area of 450 m by 450 m. Our results suggest that three of the seven models employed allow us to differentiate with clarity what is anthropic from the natural terrain and, in some scenarios, the location of construction and demolition waste. The LD model was the one with the best results, allowing an increase in the number of locations of illegal dumping of CDW in the study area.
Fractal Characteristics of the Particle Size Distribution of Soil along an Urban–Suburban–Rural–Desert Gradient
Authors: Wang Ning , Eziz Mamattursun , Mao Donglei , Sidekjan Nazupar
Published: November 2023

In order to investigate the difference in particle size distribution of soil along an urban–suburban–rural–desert (USRD) gradient in an arid zone, surface soil (0–20 cm) samples were gathered at the urban, suburban, rural, and desert gradients in Urumqi, a northwestern Chinese city. Laser diffraction technology was adopted for determining the particle size distribution of the soil. Comparisons were made regarding the particle size distribution traits and soil properties in different gradient zones based on parameters such as the mean particle size (MG), fractal dimension (Dv), sorting coefficient (ơG), kurtosis (KG), and skewness (SKG). Results indicate that (1) particle size distribution in the urban, suburban, and rural soils was mainly sand particle sizes, whereas the desert soil was mainly composed of silt particle sizes. The average Dv value ranking for soil in each gradient is desert > suburban > urban > rural. (2) The width and peak of the soil particle size frequency curve ranged within 0–500 μm, and the width and peak of the soil particle size frequency curve of each gradient were different. (3) The MG of rural soil was the highest, whereas the MG of desert soil was the lowest. The ơG values of the surface soil of each gradient were all greater than 4.0, and the sorting performance was extremely poor. The SKG of the desert and urban soil particle size showed extremely positive and negative skewness, respectively, while the SKG of the rural and suburban soil particle size showed extremely negative skewness. The KG values of the particle sizes of the rural and suburban soils exhibited narrow and medium peaks, whereas those of the urban and desert soils exhibited very broad and flat peaks. (4) The Dv of the soil in each gradient was strongly influenced by the soil particle size distribution, with the clay content of the soil playing a dominant role. Finally, the fractal dimension was identified as an indicator of the characteristics of the fine particle matter content in the soil structure. The novel contribution of this work is to clarify the fractal differences in the particle size distribution of soil along an urbanization gradient. The present research findings can offer fundamental information relating to the characteristics of soil particle size distribution along an urbanization gradient zone.
From Omics Analysis toward Physiological Mechanism Research in Plants
Authors: Lu Yan , Meng Sen , Luo Jie
Published: November 2023

With the development of big data in system biology researches, the high-throughput omics analysis has become the most popular high technology in the fields of plant research [...]
Results of Aortic Coarctation Repair in Low- and Normal Birth-Weight Neonates: A Propensity Score-Matched Analysis
Authors: Krylova Aleksandra , Svobodov Andrey , Tumanyan Margarita , Levchenko Elena , Kotov Sergey , Butrim Yuliya , Shvartz Vladimir
Published: November 2023

Introduction: Surgical treatment of aortic coarctation in low-birth-weight (LBW) neonates is associated with risks of higher hospital mortality rates and recoarctation development in the long-term. The goal of our study was to compare the results of surgical treatment of aortic coarctation in LBW neonates and normal-weight patients, to identify predictors of recoarctation in the long-term among LBW patients. Materials and methods: A retrospective study was performed to analyse the patients who had undergone resection of isolated aortic coarctation between 2005 and 2022. Overall analysis included 521 patients under the age of 30 days, 89 LBW patients and 432 patients with normal body weight. Propensity score matching (PSM) was performed at a ratio of 1:1 for the statistical adjustment of original patients’ data in both groups. Results: All patients underwent standard resection of aortic coarctation with extended end-to-end anastomosis. Hospital mortality among LBW patients was 8% and in patients with normal weight the mortality amounted to 1% (p = 0.030). LBW patients were transferred to other hospitals more often than normal-weight patients who were more often discharged (p < 0.001). In the long-term, period mortality was not statistically significantly different (p = 0.801). The freedom from reoperation in the group of normal-weight children was 87%, whereas in the LBW patients the rate was 63% (log rank test, p = 0.104). In the multivariate regression model, the most significant risk factors for reoperation were as follows: preoperative inotropes administration (OR (95% CI) 4.369 (1.316–14.51)) and pressure gradient across aortic arch before discharge (OR (95% CI) 1.081 (1.014–1.153)). Conclusions: Hospital mortality was higher among LBW patients (p = 0.030). There was a statistical trend of differences in reoperation rates: in the long-term among LBW patients, a higher reintervention probability remains. Moreover, the LBW group initially had more severe clinical condition in terms of cardiac failure and impaired renal function. Factors associated with the risk of recoarctation were preoperative inotropes infusion and pressure gradient across aortic before discharge.
A Low-Cost Silica Fiber/Epoxy Composite with Excellent Dielectric Properties, and Good Mechanical and Thermal Stability
Authors: Haider Imran , Gul Iftikhar Hussain , Umer Malik Adeel , Baig Mutawara Mahmood
Published: November 2023

In many electronic applications, the dielectric and structural properties of reinforced composites are vital. In this research work, the influence of fiber proportion on the properties of a silica fiber/epoxy (SFE) composite was investigated. The structure, morphology, dielectric constant and loss factor, mechanical properties, and thermal stability were determined. The increase of wt.% of silica fiber (SiO2 (f)) x = 30 to 90, reduced the dielectric constant (εr) and dielectric loss (δ) of the SFE composite from their original values to 18.9% and 48.5%, lowering local charge displacement towards the applied electric field. The SFE composite showed higher mechanical properties with the increase in SiO2 (f), x = 30 to 80, the tensile strength (UTS) was raised from 91.6 MPa to 155.7 MPa, the compression strength (UCS) was increased from 261.1 MPa to 409.6 MPa and the flexural strength was enhanced from 192.3 MPa to 311.9 MPa. Upon further addition of SiO2 (f) to the composite, i.e., x = 90, the mechanical properties were reduced a little, but the dielectric properties were not changed. Increasing SiO2 (f) improved the thermal stability as weight loss was found to be 69% (x = 30) and 24% (x = 90), and average moisture absorption was found to be 1.1 to 1.8%. A silica fiber/epoxy composite, for microelectronics, can be made from a low-cost fiber, and its dielectric properties as well as its mechanical and thermal stability can be tuned or improved by varying fiber fractions.
Synthesis and Characterization of High-Purity, High-Entropy Diboride Ceramic Powders by a Liquid Phase Method
Authors: Gong Weilu , Wang Tiyuan , Luo Wei , Du Youpei , Ye Li , Song Riheng , Cui Haifeng , Zhao Tong , Yang Wei , Dai Zhen , Hong Yiqiang
Published: November 2023

A nano-dual-phase powder with ultra-fine grain size was synthesized by the liquid precursor method at 1200 °C. A series of single-phase high-entropy ceramic powders ((Ti, Zr, Hf, Nb)B2, (Ti, Zr, Hf, Nb, Ta)B2, (Ti, Zr, Hf, Nb, Mo)B2, (Ti, Zr, Hf, Nb, Ta, Mo)B2) with high purity (C content less than 0.9 wt% and O content less than 0.7 wt%) and ultrafine (average grain sizes of 340–570 nm) were successfully synthesized at 1800 °C. The sample of (TiZrHfNbTa)B2 exhibited a hexagonal close-packed (HCP) structure, and the metal elements were uniformly distributed at the nanoscale, microscale, and macroscale. This method did not apply to the preparation of all high-entropy ceramic powders and was unfavorable for the formation of single-phase high-entropy borides when the size difference factor exceeded 3.9%. The present work provides a guide for the development of ceramic-based composites through precursor impregnation pyrolysis.
Non-Destructive Testing Methods for In Situ Crack Measurements and Morphology Analysis with a Focus on a Novel Approach to the Use of the Acoustic Emission Method
Authors: Świt Grzegorz , Krampikowska Aleksandra , Tworzewski Paweł
Published: November 2023

This article presents a concise review of modern non-destructive testing (NDT) methods that allow the detection, tracking, and measurement of cracks in reinforced concrete structures. Over the past decades, the range of solutions available on the market has increased. This provides excellent opportunities when choosing and designing systems for diagnosing and continuously monitoring structures. Cracking affects the mechanical properties, durability, and serviceability of a structure or its elements. Therefore, there is a need to develop methods that would allow the determination of the moment of a destructive process’s formation, i.e., a crack’s appearance. At the same time, it is crucial to be able to track the development of cracks for the entire structure, not just selected locations. This work also presents the concept of combining selected NDT methods and creating a system for the continuous monitoring of structural integrity and predicting changes in the durability of existing and future buildings.
Exploring Hormone Therapy Effects on Reproduction and Health in Transgender Individuals
Authors: Moustakli Efthalia , Tsonis Orestis
Published: November 2023

Transgender individuals often face elevated mental health challenges due to gender dysphoria, but gender-affirming treatments such as surgery and hormone therapy have been linked to significant improvements in mental well-being. The potential influence of time and circadian rhythms on these treatments is prevalent. The intricate interplay between hormones, clock genes, and fertility is profound, acknowledging the complexity of reproductive health in transgender individuals. Furthermore, risks associated with gender-affirming hormonal therapy and potential complications of puberty suppression emphasize the importance of ongoing surveillance for these patients and the need of fertility preservation and family-building options for transgender individuals. This narrative review delves into the intricate landscape of hormone therapy for transgender individuals, shedding light on its impact on bone, cardiovascular, and overall health. It explores how hormone therapy affects bone maintenance and cardiovascular risk factors, outlining the complex interplay of testosterone and estrogen. It also underscores the necessity for further research, especially regarding the long-term effects of transgender hormones. This project emphasizes the critical role of healthcare providers, particularly obstetricians and gynecologists, in providing affirming care, calling for comprehensive understanding and integration of transgender treatments. This review will contribute to a better understanding of the impact of hormone therapy on reproductive health and overall well-being in transgender individuals. It will provide valuable insights for healthcare providers, policymakers, and transgender individuals themselves, informing decision-making regarding hormone therapy and fertility preservation options. Additionally, by identifying research gaps, this review will guide future studies to address the evolving healthcare needs of transgender individuals. This project represents a critical step toward addressing the complex healthcare needs of this population. By synthesizing existing knowledge and highlighting areas for further investigation, this review aims to improve the quality of care and support provided to transgender individuals, ultimately enhancing their reproductive health and overall well-being.
Gestational Diabetes Mellitus: Association with Maternal and Neonatal Complications
Authors: Karkia Rebecca , Giacchino Tara , Shah Saadia , Gough Andrew , Ramadan Ghada , Akolekar Ranjit
Published: November 2023

Background and objectives: Gestational diabetes mellitus (GDM) is known to be associated with pregnancy complications but there is limited evidence about the strength of these associations in recent clinical practice, especially after the introduction of strict guidelines for the management of pregnancies with GDM in a multidisciplinary team setting. The objectives of our study were to first compare the rates of complications in pregnancies with GDM with those that had pre-existing diabetes mellitus and those without diabetes; and second, to derive measures of effect size expressed as odds ratios after adjustment for confounding factors to assess the independent association of GDM in prediction of these pregnancy complications. Materials and Methods: This was a prospective cohort study undertaken at a large maternity unit in the United Kingdom between January 2010 and June 2022. We included singleton pregnancies that were booked at our unit at 11–13 weeks’ gestation. Multivariate regression analysis was carried out to determine the risks of complications in pregnancies with GDM after adjusting for pregnancy characteristics. Risks were expressed as odds ratio (OR) (95% confidence intervals [CI]) and expressed graphically in forest plots. Results: The study population included 53,649 singleton pregnancies including 509 (1%) with pre-existing DM, 2089 (4%) with GDM and 49,122 (95%) pregnancies without diabetes. Multivariate regression analysis demonstrated that there was a significant independent contribution from GDM in the prediction of adverse outcomes, including maternal complications such as preterm delivery, polyhydramnios, preeclampsia and delivery of large for gestational age neonates and elective caesarean section (CS); and neonatal complications including admission to neonatal intensive care unit, hypoglycaemia, jaundice and respiratory distress syndrome. Conclusions: GDM is associated with an increased rate of pregnancy complications compared to those without diabetes, even after adjustment for maternal and pregnancy characteristics. GDM does not increase the risk of stillbirth, hypoxic ischaemic encephalopathy or neonatal death.
Towards Optimizing Width Modulation for Maximum Thermoelectric Efficiency
Authors: Stefanou Antonios-Dimitrios , Zianni Xanthippi
Published: November 2023

Maximizing thermoelectric efficiency is typically addressed as identical to minimizing parasitic thermal conduction. Such an approach relies on the assumption that the adopted strategy mainly affects phonons, leaving electrons intact, and is not justified in many cases of non-uniform nanostructures such as width-modulated nanowaveguides, where both electrons and phonons are significantly affected by width modulation. Here, we address the question of maximizing the thermoelectric efficiency of this class of metamaterials by exploring the effect of the modulation extent on both electron and phonon transport. We investigated the effect of increasing modulation degree on the thermoelectric efficiency, considering the cases of (a) a two-QD modulation and (b) multiple-QD modulations in periodic and aperiodic sequences. We show that the thermoelectric efficiency depends on the coupling between the modulation units and the interplay between periodicity and aperiodicity in the modulation profile. We reveal that the maximization of the thermoelectric power factor is for periodic width-modulation, whereas the maximization of the thermoelectric efficiency is for aperiodic width-modulation profiles that form quasi-localized states for electrons. Our work provides new insight that can be used to optimize width modulation for maximum thermoelectric efficiency.
Sensitive Detection of Trace Explosives by a Self-Assembled Monolayer Sensor
Authors: Liu Weitao , Ali Wajid , Liu Ye , Li Mingliang , Li Ziwei
Published: November 2023

Fluorescence probe technology holds great promise in the application of trace explosive detection due to its high sensitivity, fast response speed, good selectivity, and low cost. In this work, a designed approach has been employed to prepare the TPE-PA-8 molecule, utilizing the classic aggregation-induced emission (AIE) property of 1,1,2,2-tetraphenylethene (TPE), for the development of self-assembled monolayers (SAMs) targeting the detection of trace nitroaromatic compound (NAC) explosives. The phosphoric acid acts as an anchoring unit, connecting to TPE through an alkyl chain of eight molecules, which has been found to play a crucial role in promoting the aggregation of TPE luminogens, leading to the enhanced light-emission property and sensing performance of SAMs. The SAMs assembled on Al2O3-deposited fiber film exhibit remarkable detection performances, with detection limits of 0.68 ppm, 1.68 ppm, and 2.5 ppm for trinitrotoluene, dinitrotoluene, and nitrobenzene, respectively. This work provides a candidate for the design and fabrication of flexible sensors possessing the high-performance and user-friendly detection of trace NACs.
Establishment of a Halophilic Bloom in a Sterile and Isolated Hypersaline Mesocosm
Authors: Rhodes Matthew E. , Pace Allyson D. , Benjamin Menny M. , Ghent Heather , Dawson Katherine S.
Published: November 2023

Extreme environments, including hypersaline pools, often serve as biogeographical islands. Putative colonizers would need to survive transport across potentially vast distances of inhospitable terrain. Hyperhalophiles, in particular, are often highly sensitive to osmotic pressure. Here, we assessed whether hyperhalophiles are capable of rapidly colonizing an isolated and sterile hypersaline pool and the order of succession of the ensuing colonizers. A sterile and isolated 1 m3 hypersaline mesocosm pool was constructed on a rooftop in Charleston, SC. Within months, numerous halophilic lineages successfully navigated the 20 m elevation and the greater than 1 km distance from the ocean shore, and a vibrant halophilic community was established. All told, in a nine-month period, greater than a dozen halophilic genera colonized the pool. The first to arrive were members of the Haloarchaeal genus Haloarcula. Like a weed, the Haloarcula rapidly colonized and dominated the mesocosm community but were later supplanted by other hyperhalophilic genera. As a possible source of long-distance inoculum, both aerosol and water column samples were obtained from the Great Salt Lake and its immediate vicinity. Members of the same genus, Haloarcula, were preferentially enriched in the aerosol sample relative to the water column samples. Therefore, it appears that a diverse array of hyperhalophiles are capable of surviving aeolian long-distance transport and that some lineages, in particular, have possibly adapted to that strategy.
Characterization and Provenance of Carbonate Rocks for Quicklime and Dololime Production in Twin-Shaft Regenerative Kilns from the Arabian Peninsula and Neighboring Countries
Authors: Vola Gabriele , Ardit Matteo , Frijia Gianluca , Di Benedetto Francesco , Fornasier Flavio , Lugli Federico , Natali Claudio , Sarandrea Luca , Schmitt Katharina Elena , Cipriani Anna
Published: November 2023

This study analyzes high-grade carbonate rocks from several strategic deposits in the Arabian Peninsula and neighboring countries. The rocks are used locally for quicklime and dololime production in twin-shaft regenerative kilns. Stable C-O-Sr isotopes, along with chemical, mineralogical-petrographic analyses, micropaleontological investigations, cathodoluminescence microscopy, organic carbon speciation, and electron paramagnetic resonance spectroscopy, were used to trace the provenance of these rocks from economically significant non-metallic deposits. The resulting database can help identify and differentiate industrial raw materials that may appear similar chemically and/or macroscopically but have different textures/microstructures that can affect the properties of the derived burnt lime products. Various technological tests, including slaking reactivity, sticking tendency at high-temperature (i.e., 1300 °C), and physico-mechanical behavior of the lime, were performed to evaluate their suitability and predict lime performance in twin-shaft regenerative kilns. Comparison of laboratory and plant results validated the resulting database.
Preventive Effect of Arctium lappa Polysaccharides on Acute Lung Injury through Anti-Inflammatory and Antioxidant Activities
Authors: Lu Naiyan , Wei Jiayi , Gong Xuelei , Tang Xue , Zhang Xuan , Xiang Wen , Liu Samuel , Luo Cherry , Wang Xun
Published: November 2023

The objective of this study was to investigate the preventive effects of polysaccharides extracted from the roots of Arctium lappa (ALP) against acute lung injury (ALI) models induced by lipopolysaccharide (LPS). The polysaccharides were extracted and characterized, and their anti-inflammatory and antioxidant capacities were assessed. The findings demonstrated that ALP could mitigate the infiltration of inflammatory cells and reduce alveolar collapse in LPS-induced ALI in mice. The expression levels of the pro-inflammatory factor TNF-α decreased, while the anti-inflammatory factor IL-10 increased. Furthermore, the administration of ALP improved the activities of lung antioxidant enzymes, including SOD, GSH, and CAT, and lowered MDA levels. These results suggest that ALP exhibits a preventive effect on ALI and has potential as an alternative treatment for lung injury.
Reply to Boucher, B.J. Comment on “Lopes et al. Adiposity Metabolic Consequences for Adolescent Bone Health. Nutrients 2022, 14, 3260”
Authors: Lopes Kátia Gianlupi , Rodrigues Elisana Lima , da Silva Lopes Mariana Rodrigues , do Nascimento Valter Aragão , Pott Arnildo , Guimarães Rita de Cássia Avellaneda , Pegolo Giovana Eliza , Freitas Karine de Cássia
Published: November 2023

We appreciate your careful reading and comments [...]
Association of a Combination of Sarcopenia and Type 2 Diabetes with Blood Parameters, Nutrient Intake, and Physical Activity: A Nationwide Population-Based Study
Authors: Kim Mijin , Kobori Toshiro
Published: November 2023

This study aimed to investigate the association of sarcopenia and type 2 diabetes (T2D) with blood parameters, nutrient intake, and physical activity in older Korean adults. We divided 2952 participants into four groups: sarcopenic diabetes (SD), sarcopenia alone (S), diabetes alone (D), and non-sarcopenia and non-diabetes (NSND). Sarcopenia was defined by the appendicular skeletal muscle mass index, and T2D by fasting glucose levels or ongoing treatment. Blood samples were collected after an 8-h fast. Nutrient intake was assessed using a 24-h recall; physical activity was evaluated using a questionnaire. Compared with those in the other groups, the men in the S and SD groups showed significantly lower hemoglobin and hematocrit levels; vitamin D levels in men and parathyroid hormone levels in women were significantly lower in the SD group. Total energy, protein, and carbohydrate intakes were significantly lower in the SD and S groups than those in the D and NSND groups. Physical inactivity was significantly more common in the SD group (men: odds ratio, 1.61; women: odds ratio, 2.37) than in the NSND group. A combination of sarcopenia and diabetes as well as sarcopenia alone was associated with low levels of blood parameters, poor nutrient intake, and low physical activity.