bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatio-temporal correlations in the Manna model in one, three and five dimensions
Authors: Willis Gary , Pruessner Gunnar
Published: November 2017

Although the paradigm of criticality is centered around spatial correlations and their anomalous scaling, not many studies of self-organized criticality (SOC) focus on spatial correlations. Often, integrated observables, such as avalanche size and duration, are used, not least as to avoid complications due to the unavoidable lack of translational invariance. The present work is a survey of spatio-temporal correlation functions in the Manna Model of SOC, measured numerically in detail in [Formula: see text] = 1,3 and 5 dimensions and compared to theoretical results, in particular relating them to “integrated” observables such as avalanche size and duration scaling, that measure them indirectly. Contrary to the notion held by some of SOC models organizing into a critical state by re-arranging their spatial structure avalanche by avalanche, which may be expected to result in large, nontrivial, system-spanning spatial correlations in the quiescent state (between avalanches), correlations of inactive particles in the quiescent state have a small amplitude that does not and cannot increase with the system size, although they display (noisy) power law scaling over a range linear in the system size. Self-organization, however, does take place as the (one-point) density of inactive particles organizes into a particular profile that is asymptotically independent of the driving location, also demonstrated analytically in one dimension. Activity and its correlations, on the other hand, display nontrivial long-ranged spatio-temporal scaling with exponents that can be related to established results, in particular avalanche size and duration exponents. The correlation length and amplitude are set by the system size (confirmed analytically for some observables), as expected in systems displaying finite size scaling. In one dimension, we find some surprising inconsistencies of the dynamical exponent. A (spatially extended) mean field theory (MFT) is recovered, with some corrections, in five dimensions.
Analysis and Stabilization of Chaos in Permanent Magnet DC Motor Driver
Authors: Tahir Fadhil Rahma , Abdul-Hassan Khalid M. , Abdullah Mohammed Abbas , Pham Viet-Thanh , Hoang Thang Manh , Wang Xiong
Published: November 2017

In this paper, the nonlinear dynamics of permanent magnet (PM) DC motor drive with proportional (P) controller have been investigated. The drive system shows different dynamical behaviors; periodic, quasi-periodic, and chaotic behaviors, and those are characterized by using bifurcation diagram, phase portrait, and time series. The stability analysis of period-1 behavior is studied by using Filippov’s method, the analytic results show good agreement with simulation ones. Then, the stabilization of chaos to fixed point is carried out by using the sliding mode control (SMC). In addition, experimentally the nonlinear dynamics and the proposed stabilization method to PM DC motor drive system have been achieved by using a microcontroller. For the first time, it is noted that when the system is in chaotic dynamics, the vibration of the motor is increased approximately 400% compared with the system in periodic dynamical behavior.
Adaptive synthesis of indoor scenes via activity-associated object relation graphs
Authors: Fu Qiang , Chen Xiaowu , Wang Xiaotian , Wen Sijia , Zhou Bin , Fu Hongbo
Published: November 2017

We present a system for adaptive synthesis of indoor scenes given an empty room and only a few object categories. Automatically suggesting indoor objects and proper layouts to convert an empty room to a 3D scene is challenging, since it requires interior design knowledge to balance the factors like space, path distance, illumination and object relations, in order to insure the functional plausibility of the synthesized scenes. We exploit a database of 2D floor plans to extract object relations and provide layout examples for scene synthesis. With the labeled human positions and directions in each plan, we detect the activity relations and compute the coexistence frequency of object pairs to construct activity-associated object relation graphs. Given the input room and user-specified object categories, our system first leverages the object relation graphs and the database floor plans to suggest more potential object categories beyond the specified ones to make resulting scenes functionally complete, and then uses the similar plan references to create the layout of synthesized scenes. We show various synthesis results to demonstrate the practicability of our system, and validate its usability via a user study. We also compare our system with the state-of-the-art furniture layout and activity-centric scene representation methods, in terms of functional plausibility and user friendliness.
Microfacet-based normal mapping for robust Monte Carlo path tracing
Authors: Schüssler Vincent , Heitz Eric , Hanika Johannes , Dachsbacher Carsten
Published: November 2017

Normal mapping enhances the amount of visual detail of surfaces by using shading normals that deviate from the geometric normal. However, the resulting surface model is geometrically impossible and normal mapping is thus often considered a fundamentally flawed approach with unavoidable problems for Monte Carlo path tracing, such as asymmetry, back-facing normals, and energy loss arising from this incoherence. These problems are usually sidestepped in real-time renderers, but they cannot be fixed robustly in a path tracer: normal mapping breaks either the appearance (black fringes, energy loss) or the integrator (different forward and backward light transport); in practice, workarounds and tweaked normal maps are often required to hide artifacts.

We present microfacet-based normal mapping, an alternative way of faking geometric details without corrupting the robustness of Monte Carlo path tracing. It takes the same input data as classic normal mapping and works with any input BRDF. Our idea is to construct a geometrically valid microfacet surface made of two facets per shading point: the one given by the normal map at the shading point and an additional facet that compensates for it such that the average normal of the microsurface equals the geometric normal. We derive the resulting microfacet BRDF and show that it mimics geometric detail in a plausible way, although it does not replicate the appearance of classic normal mapping. However, our
microfacet-based normal mapping
model is well-defined, symmetric, and energy conserving, and thus yields identical results with any path tracing algorithm (forward, backward, or bidirectional).
Position-based tensegrity design
Authors: Pietroni Nico , Tarini Marco , Vaxman Amir , Panozzo Daniele , Cignoni Paolo
Published: November 2017

We propose a novel framework for the computational design of tensegrity structures, which are constructions made of struts and cables, held rigid by continuous tension between the elements. Tensegrities are known to be difficult to design---existing design methods are often restricted to using symmetric or templated configurations, limiting the design space to simple constructions. We introduce an algorithm to automatically create free-form stable tensegrity designs that satisfy both fabrication and geometric constraints, and faithfully approximate input geometric shapes. Our approach sidesteps the usual force-based approach in favor of a geometric optimization on the positions of the elements. Equipped with this formulation, we provide a design framework to explore the highly constrained space of tensegrity structures. We validate our method with simulations and real-world constructions.
High-quality hyperspectral reconstruction using a spectral prior
Authors: Choi Inchang , Jeon Daniel S. , Nam Giljoo , Gutierrez Diego , Kim Min H.
Published: November 2017

We present a novel hyperspectral image reconstruction algorithm, which overcomes the long-standing tradeoff between spectral accuracy and spatial resolution in existing compressive imaging approaches. Our method consists of two steps: First, we learn nonlinear spectral representations from real-world hyperspectral datasets; for this, we build a convolutional autoencoder which allows reconstructing its own input through its encoder and decoder networks. Second, we introduce a novel optimization method, which jointly regularizes the fidelity of the learned nonlinear spectral representations and the sparsity of gradients in the spatial domain, by means of our new fidelity prior. Our technique can be applied to any existing compressive imaging architecture, and has been thoroughly tested both in simulation, and by building a prototype hyperspectral imaging system. It outperforms the state-of-the-art methods from each architecture, both in terms of spectral accuracy and spatial resolution, while its computational complexity is reduced by two orders of magnitude with respect to sparse coding techniques. Moreover, we present two additional applications of our method: hyperspectral interpolation and demosaicing. Last, we have created a new high-resolution hyperspectral dataset containing sharper images of more spectral variety than existing ones, available through our project website.
Fabricable tile decors
Authors: Chen Weikai , Ma Yuexin , Lefebvre Sylvain , Xin Shiqing , Martínez Jonàs , wang wenping
Published: November 2017

Recent advances in 3D printing have made it easier to manufacture customized objects by ordinary users in an affordable manner, and therefore spurred high demand for more accessible methods for designing and fabricating 3D objects of various shapes and functionalities. In this paper we present a novel approach to model and fabricate surface-like objects composed of connected tiles, which can be used as objects in daily life, such as ornaments, covers, shades or handbags.
Bringing portraits to life
Authors: Averbuch-Elor Hadar , Cohen-Or Daniel , Kopf Johannes , Cohen Michael F.
Published: November 2017

We present a technique to automatically animate a still portrait, making it possible for the subject in the photo to come to life and express various emotions. We use a driving video (of a different subject) and develop means to transfer the expressiveness of the subject in the driving video to the target portrait. In contrast to previous work that requires an input video of the target face to reenact a facial performance, our technique uses only a
single
target image. We animate the target image through 2D warps that imitate the facial transformations in the driving video. As warps alone do not carry the full expressiveness of the face, we add fine-scale dynamic details which are commonly associated with facial expressions such as creases and wrinkles. Furthermore, we hallucinate regions that are hidden in the input target face, most notably in the inner mouth. Our technique gives rise to
reactive profiles
, where people in still images can automatically interact with their viewers. We demonstrate our technique operating on numerous still portraits from the internet.
3Dlite
Authors: Huang Jingwei , Dai Angela , Guibas Leonidas , Niessner Matthias
Published: November 2017

We present 3DLite
1
, a novel approach to reconstruct 3D environments using consumer RGB-D sensors, making a step towards directly utilizing captured 3D content in graphics applications, such as video games, VR, or AR. Rather than reconstructing an accurate one-to-one representation of the real world, our method computes a lightweight, low-polygonal geometric abstraction of the scanned geometry. We argue that for many graphics applications it is much more important to obtain high-quality surface textures rather than highly-detailed geometry. To this end, we compensate for motion blur, auto-exposure artifacts, and micro-misalignments in camera poses by warping and stitching image fragments from low-quality RGB input data to achieve high-resolution, sharp surface textures. In addition to the observed regions of a scene, we extrapolate the scene geometry, as well as the mapped surface textures, to obtain a complete 3D model of the environment. We show that a simple planar abstraction of the scene geometry is ideally suited for this completion task, enabling 3DLite to produce complete, lightweight, and visually compelling 3D scene models. We believe that these CAD-like reconstructions are an important step towards leveraging RGB-D scanning in actual content creation pipelines.
A hyperbolic geometric flow for evolving films and foams
Authors: Ishida Sadashige , Yamamoto Masafumi , Ando Ryoichi , Hachisuka Toshiya
Published: November 2017

Simulating the behavior of soap films and foams is a challenging task. A direct numerical simulation of films and foams via the Navier-Stokes equations is still computationally too expensive. We propose an alternative formulation inspired by geometric flow. Our model exploits the fact, according to Plateau's laws, that the steady state of a film is a union of constant mean curvature surfaces and minimal surfaces. Such surfaces are also well known as the steady state solutions of certain curvature flows. We show a link between the Navier-Stokes equations and a recent variant of mean curvature flow, called
hyperbolic mean curvature flow
, under the assumption of constant air pressure per enclosed region. Instead of using hyperbolic mean curvature flow as is, we propose to replace curvature by the gradient of the surface area functional. This formulation enables us to robustly handle non-manifold configurations; such junctions connecting multiple films are intractable with the traditional formulation using curvature. We also add explicit volume preservation to hyperbolic mean curvature flow, which in fact corresponds to the pressure term of the Navier-Stokes equations. Our method is simple, fast, robust, and consistent with Plateau's laws, which are all due to our reformulation of film dynamics as a geometric flow.
SpinVR
Authors: Konrad Robert , Dansereau Donald G. , Masood Aniq , Wetzstein Gordon
Published: November 2017

Streaming of 360° content is gaining attention as an immersive way to remotely experience live events. However live capture is presently limited to 2D content due to the prohibitive computational cost associated with multi-camera rigs. In this work we present a system that directly captures streaming 3D virtual reality content. Our approach does not suffer from spatial or temporal seams and natively handles phenomena that are challenging for existing systems, including refraction, reflection, transparency and speculars. Vortex natively captures in the omni-directional stereo (ODS) format, which is widely supported by VR displays and streaming pipelines. We identify an important source of distortion inherent to the ODS format, and demonstrate a simple means of correcting it. We include a detailed analysis of the design space, including tradeoffs between noise, frame rate, resolution, and hardware complexity. Processing is minimal, enabling live transmission of immersive, 3D, 360° content. We construct a prototype and demonstrate capture of 360° scenes at up to 8192 X 4096 pixels at 5 fps, and establish the viability of operation up to 32 fps.
Robust structure simplification for hex re-meshing
Authors: Gao Xifeng , Panozzo Daniele , Wang Wenping , Deng Zhigang , Chen Guoning
Published: November 2017

We introduce a robust and automatic algorithm to simplify the structure and reduce the singularities of a hexahedral mesh. Our algorithm interleaves simplification operations to collapse sheets and chords of the base complex of the input mesh with a geometric optimization, which improves the elements quality. All our operations are guaranteed not to introduce elements with negative Jacobians, ensuring that our algorithm always produces valid hex-meshes, and not to increase the Hausdorff distance from the original shape more than a user-defined threshold, ensuring a faithful approximation of the input geometry. Our algorithm can improve meshes produced with any existing hexahedral meshing algorithm --- we demonstrate its effectiveness by processing a dataset of 194 hex-meshes created with octree-based, polycube-based, and field-aligned methods.
An adaptive generalized interpolation material point method for simulating elastoplastic materials
Authors: Gao Ming , Tampubolon Andre Pradhana , Jiang Chenfanfu , Sifakis Eftychios
Published: November 2017

We present an adaptive Generalized Interpolation Material Point (GIMP) method for simulating elastoplastic materials. Our approach allows adaptive refining and coarsening of different regions of the material, leading to an efficient MPM solver that concentrates most of the computation resources in specific regions of interest. We propose a
C
1
continuous adaptive basis function that satisfies the partition of unity property and remains non-negative throughout the computational domain. We develop a practical strategy for particle-grid transfers that leverages the recently introduced SPGrid data structure for storing sparse multi-layered grids. We demonstrate the robustness and efficiency of our method on the simulation of various elastic and plastic materials. We also compare key kernel components to uniform grid MPM solvers to highlight performance benefits of our method.
Photo2clipart
Authors: Favreau Jean-Dominique , Lafarge Florent , Bousseau Adrien
Published: November 2017

We present a method to create vector cliparts from photographs. Our approach aims at reproducing two key properties of cliparts: they should be easily editable, and they should represent image content in a clean, simplified way. We observe that vector artists satisfy both of these properties by modeling cliparts with linear color gradients, which have a small number of parameters and approximate well smooth color variations. In addition, skilled artists produce intricate yet editable artworks by stacking multiple gradients using opaque and semi-transparent layers. Motivated by these observations, our goal is to decompose a bitmap photograph into a stack of layers, each layer containing a vector path filled with a linear color gradient. We cast this problem as an optimization that jointly assigns each pixel to one or more layer and finds the gradient parameters of each layer that best reproduce the input. Since a trivial solution would consist in assigning each pixel to a different, opaque layer, we complement our objective with a simplicity term that favors decompositions made of few, semi-transparent layers. However, this formulation results in a complex combinatorial problem combining discrete unknowns (the pixel assignments) and continuous unknowns (the layer parameters). We propose a Monte Carlo Tree Search algorithm that efficiently explores this solution space by leveraging layering cues at image junctions. We demonstrate the effectiveness of our method by reverse-engineering existing cliparts and by creating original cliparts from studio photographs.
Dynamism of an Astrocyte In Vivo: Perspectives on Identity and Function
Authors: Poskanzer Kira E. , Molofsky Anna V.
Published: November 2017

Astrocytes are an abundant and evolutionarily conserved central nervous system cell type. Despite decades of evidence that astrocytes are integral to neural circuit function, it seems as though astrocytic and neuronal biology continue to advance in parallel to each other, to the detriment of both. Recent advances in molecular biology and optical imaging are being applied to astrocytes in new and exciting ways but without fully considering their unique biology. From this perspective, we explore the reasons that astrocytes remain enigmatic, arguing that their responses to neuronal and environmental cues shape form and function in dynamic ways. Here, we provide a roadmap for future experiments to explore the nature of astrocytes in situ.
Two Classes of Secreted Synaptic Organizers in the Central Nervous System
Authors: Yuzaki Michisuke
Published: November 2017

Research in the last two decades has identified many synaptic organizers in the central nervous system that directly regulate the assembly of pre- and/or postsynaptic molecules, such as synaptic vesicles, active zone proteins, and neurotransmitter receptors. They are classified into secreted factors and cell adhesion molecules, such as neurexins and neuroligins. Certain secreted factors are termed extracellular scaffolding proteins (ESPs) because they are components of the synaptic extracellular matrix and serve as a scaffold at the synaptic cleft. These include Lgi1, Cbln1, neuronal pentraxins, Hevin, thrombospondins, and glypicans. Diffusible secreted factors, such as Wnts, fibroblast growth factors, and semaphorins, tend to act from a distance. In contrast, ESPs remain at the synaptic cleft and often help synaptic adhesion and/or accumulation of postsynaptic receptors. Many fundamental questions remain about when, how, and why various synaptic organizers establish and modify the vast numbers of connections during development and throughout life.
The dawn of succinylation: a posttranslational modification
Authors: Alleyn Matthew , Breitzig Mason , Lockey Richard , Kolliputi Narasaiah
Published: November 2017

Posttranslational modifications affect almost all proteins and are critical to a well-functioning and diverse proteome; however, many modifications remain relatively unknown and unstudied. This paper will give a perspective on the rapidly developing, novel posttranslational modification called succinylation. This modification may be implicated in numerous diseases, such as hepatic, cardiac, and pulmonary diseases. Although the influences of this modification still remain poorly understood, we are confident that further research into succinylation will provide an enhanced understanding of the complex machinery within the mitochondria, as well as the imposing consequences associated with its dysfunction.
Epigenetic modulation of intestinal Na+/H+ exchanger-3 expression
Authors: Kumar Anoop , Malhotra Pooja , Coffing Hayley , Priyamvada Shubha , Anbazhagan Arivarasu N. , Krishnan Harish R. , Gill Ravinder K. , Alrefai Waddah A. , Gavin David P. , Pandey Subhash C. , Dudeja Pradeep K. , Saksena Seema
Published: November 2017

Na+/H+ exchanger-3 (NHE3) is crucial for intestinal Na+ absorption, and its reduction has been implicated in infectious and inflammatory bowel diseases (IBD)-associated diarrhea. Epigenetic mechanisms such as DNA methylation are involved in the pathophysiology of IBD. Whether changes in DNA methylation are involved in modulating intestinal NHE3 gene expression is not known. Caco-2 and HuTu 80 cells were used as models of human intestinal epithelial cells. Normal C57/BL6, wild-type, or growth arrest and DNA damage-inducible 45b (GADD45b) knockout (KO) mice were used as in vivo models. NHE3 gene DNA methylation levels were assessed by MBDCap (MethyMiner) assays. Results demonstrated that in vitro methylation of NHE3 promoter construct (p-1509/+127) cloned into a cytosine guanine dinucleotide-free lucia vector decreased the promoter activity in Caco-2 cells. DNA methyltransferase inhibitor 5-azacytidine (10 μM, 24 h) caused a significant decrease in DNA methylation of the NHE3 gene and concomitantly increased NHE3 expression in Caco-2 cells. Similarly, 5-azacytidine treatment increased NHE3 mRNA levels in HuTu 80 cells. 5-Azacytidine treatment for 3 wk (10 mg/kg body wt ip, 3 times/wk) also resulted in an increase in NHE3 expression in the mouse ileum and colon. Small-interfering RNA knockdown of GADD45b (protein involved in DNA demethylation) in Caco-2 cells decreased NHE3 mRNA expression. Furthermore, there was a significant decrease in NHE3 mRNA and protein expression in the ileum and colon of GADD45b KO mice. Our findings demonstrate that NHE3 gene expression is regulated by changes in its DNA methylation.

NEW & NOTEWORTHY Our studies for the first time demonstrate that Na+/H+ exchanger-3 gene expression is regulated by an epigenetic mechanism involving DNA methylation.
Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1
Authors: Sysol Justin R. , Chen Jiwang , Singla Sunit , Zhao Shuangping , Comhair Suzy , Natarajan Viswanathan , Machado Roberto F.
Published: November 2017

Sphingosine kinase 1 (SphK1) upregulation is associated with pathologic pulmonary vascular remodeling in pulmonary arterial hypertension (PAH), but the mechanisms controlling its expression are undefined. In this study, we sought to characterize the regulation of SphK1 expression by micro-RNAs (miRs). In silico analysis of the SphK1 3′-untranslated region identified several putative miR binding sites, with miR-1-3p (miR-1) being the most highly predicted target. Therefore we further investigated the role of miR-1 in modulating SphK1 expression and characterized its effects on the phenotype of pulmonary artery smooth muscle cells (PASMCs) and the development of experimental pulmonary hypertension in vivo. Our results demonstrate that miR-1 is downregulated by hypoxia in PASMCs and can directly inhibit SphK1 expression. Overexpression of miR-1 in human PASMCs inhibits basal and hypoxia-induced proliferation and migration. Human PASMCs isolated from PAH patients exhibit reduced miR-1 expression. We also demonstrate that miR-1 is downregulated in mouse lung tissues during experimental hypoxia-mediated pulmonary hypertension (HPH), consistent with upregulation of SphK1. Furthermore, administration of miR-1 mimics in vivo prevented the development of HPH in mice and attenuated induction of SphK1 in PASMCs. These data reveal the importance of miR-1 in regulating SphK1 expression during hypoxia in PASMCs. A pivotal role is played by miR-1 in pulmonary vascular remodeling, including PASMC proliferation and migration, and its overexpression protects from the development of HPH in vivo. These studies improve our understanding of the molecular mechanisms underlying the pathogenesis of pulmonary hypertension.
NRF2 prevents hypertension, increased ADMA, microvascular oxidative stress, and dysfunction in mice with two weeks of ANG II infusion
Authors: Wang Cheng , Luo Zaiming , Carter Gabriella , Wellstein Anton , Jose Pedro A. , Tomlinson James , Leiper James , Welch William J. , Wilcox Christopher S. , Wang Dan
Published: November 2017

Nuclear factor erythyroid factor 2 (Nrf2) transcribes genes in cultured endothelial cells that reduce reactive oxygen species (ROS) and generate nitric oxide (NO) or metabolize asymmetric dimethylarginine (ADMA), which inhibits NO synthase (NOS). Therefore, we undertook a functional study to test the hypothesis that activation of Nrf2 by tert-butylhydroquinone (tBHQ) preserves microvascular endothelial function during oxidative stress. Wild-type CB57BL/6 (wt), Nrf2 wt (+/+), or knockout (−/−) mice received vehicle (Veh) or tBHQ (0.1%; activator of Nrf2) during 14-day infusions of ANG II (to induce oxidative stress) or sham. MAP was recorded by telemetry. Mesenteric resistance arterioles were studied on isometric myographs and vascular NO and ROS by fluorescence microscopy. ANG II increased the mean arterial pressure (112 ± 5 vs. 145 ± 5 mmHg; P < 0.01) and excretion of 8-isoprostane F2α (2.8 ± 0.3 vs. 3.8 ± 0.3 ng/mg creatinine; P < 0.05) at 12–14 days. However, 12 days of ANG II reduced endothelium-derived relaxation (27 ± 5 vs. 17 ± 3%; P < 0.01) and NO (0.38 ± 0.07 vs. 0.18 ± 0.03 units; P < 0.01) but increased microvascular remodeling, endothelium-derived contractions (7.5 ± 0.5 vs. 13.0 ± 1.7%; P < 0.01), superoxide (0.09 ± 0.03 vs. 0.29 ± 0.08 units; P < 0.05), and contractions to U-46,619 (87 ± 6 vs. 118 ± 3%; P < 0.05), and endothelin-1(89 ± 4 vs. 123 ± 12%; P < 0.05). tBHQ prevented all of these effects of ANG II at 12–14 days in Nrf2+/+ mice but not in Nrf2−/− mice. In conclusion, tBHQ activates Nrf2 to prevent microvascular endothelial dysfunction, remodeling, and contractility, and moderate ADMA and hypertension at 12–14 days of ANG II infusion, thereby preserving endothelial function and preventing hypertension.
Cellular mechanisms underlying obesity-induced arterial stiffness
Authors: Aroor Annayya R. , Jia Guanghong , Sowers James R.
Published: November 2017

Obesity is an emerging pandemic driven by consumption of a diet rich in fat and highly refined carbohydrates (a Western diet) and a sedentary lifestyle in both children and adults. There is mounting evidence that arterial stiffness in obesity is an independent and strong predictor of cardiovascular disease (CVD), cognitive functional decline, and chronic kidney disease. Cardiovascular stiffness is a precursor to atherosclerosis, systolic hypertension, cardiac diastolic dysfunction, and impairment of coronary and cerebral flow. Moreover, premenopausal women lose the CVD protection normally afforded to them in the setting of obesity, insulin resistance, and diabetes, and this loss of CVD protection is inextricably linked to an increased propensity for arterial stiffness. Stiffness of endothelial and vascular smooth muscle cells, extracellular matrix remodeling, perivascular adipose tissue inflammation, and immune cell dysfunction contribute to the development of arterial stiffness in obesity. Enhanced endothelial cortical stiffness decreases endothelial generation of nitric oxide, and increased oxidative stress promotes destruction of nitric oxide. Our research over the past 5 years has underscored an important role of increased aldosterone and vascular mineralocorticoid receptor activation in driving development of cardiovascular stiffness, especially in females consuming a Western diet. In this review the cellular mechanisms of obesity-associated arterial stiffness are highlighted.
Canagliflozin reduces plasma uremic toxins and alters the intestinal microbiota composition in a chronic kidney disease mouse model
Authors: Mishima Eikan , Fukuda Shinji , Kanemitsu Yoshitomi , Saigusa Daisuke , Mukawa Chikahisa , Asaji Kei , Matsumoto Yotaro , Tsukamoto Hiroki , Tachikawa Tatsuki , Tsukimi Tomoya , Fukuda Noriko N. , Ho Hsin-Jung , Kikuchi Koichi , Suzuki Chitose , Nanto Fumika , Suzuki Takehiro , Ito Sadayoshi , Soga Tomoyoshi , Tomioka Yoshihisa , Abe Takaaki
Published: November 2017

Accumulation of uremic toxins, which exert deleterious effects in chronic kidney disease, is influenced by the intestinal environment; the microbiota contributes to the production of representative uremic toxins, including p-cresyl sulfate and indoxyl sulfate. Canagliflozin is a sodium-glucose cotransporter (SGLT) 2 inhibitor, and it also exerts a modest inhibitory effect on SGLT1. The inhibition of intestinal SGLT1 can influence the gastrointestinal environment. We examined the effect of canagliflozin on the accumulation of uremic toxins in chronic kidney disease using adenine-induced renal failure mice. Two-week canagliflozin (10 mg/kg po) treatment did not influence the impaired renal function; however, it significantly reduced the plasma levels of p-cresyl sulfate and indoxyl sulfate in renal failure mice (a 75% and 26% reduction, respectively, compared with the vehicle group). Additionally, canagliflozin significantly increased cecal short-chain fatty acids in the mice, suggesting the promotion of bacterial carbohydrate fermentation in the intestine. Analysis of the cecal microbiota showed that canagliflozin significantly altered microbiota composition in the renal failure mice. These results indicate that canagliflozin exerts intestinal effects that reduce the accumulation of uremic toxins including p-cresyl sulfate. Reduction of accumulated uremic toxins by canagliflozin could provide a potential therapeutic option in chronic kidney disease.
The modulation of hippocampal theta rhythm by the vestibular system
Authors: Aitken Phillip , Zheng Yiwen , Smith Paul F.
Published: November 2017

The vestibular system is a sensory system that has evolved over millions of years to detect acceleration of the head, both rotational and translational, in three dimensions. One of its most important functions is to stabilize gaze during unexpected head movement; however, it is also important in the control of posture and autonomic reflexes. Theta rhythm is a 3- to 12-Hz oscillating EEG signal that is intimately linked to self-motion and is also known to be important in learning and memory. Many studies over the last two decades have shown that selective activation of the vestibular system, using either natural rotational or translational stimulation, or electrical stimulation of the peripheral vestibular system, can induce and modulate theta activity. Furthermore, inactivation of the vestibular system has been shown to significantly reduce theta in freely moving animals, which may be linked to its impairment of place cell function as well as spatial learning and memory. The pathways through which vestibular information modulate theta rhythm remain debatable. However, vestibular responses have been found in the pedunculopontine tegmental nucleus (PPTg) and activation of the vestibular system causes an increase in acetylcholine release into the hippocampus, probably from the medial septum. Therefore, a pathway from the vestibular nucleus complex and/or cerebellum to the PPTg, supramammillary nucleus, posterior hypothalamic nucleus, and septum to the hippocampus is likely. The modulation of theta by the vestibular system may have implications for vestibular effects on cognitive function and the contribution of vestibular impairment to the risk of dementia.
Tactile perception of the roughness of 3D-printed textures
Authors: Tymms Chelsea , Zorin Denis , Gardner Esther P.
Published: November 2017

Surface roughness is one of the most important qualities in haptic perception. Roughness is a major identifier for judgments of material composition, comfort, and friction and is tied closely to manual dexterity. Some attention has been given to the study of roughness perception in the past, but it has typically focused on noncontrollable natural materials or on a narrow range of artificial materials. The advent of high-resolution three-dimensional (3D) printing technology provides the ability to fabricate arbitrary 3D textures with precise surface geometry to be used in tactile studies. We used parametric modeling and 3D printing to manufacture a set of textured plates with defined element spacing, shape, and arrangement. Using active touch and two-alternative forced-choice protocols, we investigated the contributions of these surface parameters to roughness perception in human subjects. Results indicate that large spatial periods produce higher estimations of roughness (with Weber fraction = 0.19), small texture elements are perceived as rougher than large texture elements of the same wavelength, perceptual differences exist between textures with the same spacing but different arrangements, and roughness equivalencies exist between textures differing along different parameters. We posit that papillary ridges serve as tactile processing units, and neural ensembles encode the spatial profiles of the texture contact area to produce roughness estimates. The stimuli and the manufacturing process may be used in further studies of tactile roughness perception and in related neurophysiological applications.

NEW & NOTEWORTHY Surface roughness is an integral quality of texture perception. We manufactured textures using high-resolution 3D printing, which allows precise specification of the surface spatial topography. In human psychophysical experiments we investigated the contributions of specific surface parameters to roughness perception. We found that textures with large spatial periods, small texture elements, and irregular, isotropic arrangements elicit the highest estimations of roughness. We propose that roughness correlates inversely with the total contacted surface area.
Perceptual decisions based on previously learned information are independent of dopaminergic tone
Authors: Perugini Alessandra , Basso Michele A.
Published: November 2017

Both cognitive and motor symptoms in people with Parkinson’s disease (PD) arise from either too little or too much dopamine (DA). Akinesia stems from DA neuronal cell loss, and dyskinesia often stems from an overdose of DA medication. Cognitive behaviors typically associated with frontal cortical function, such as working memory and task switching, are also affected by too little or too much DA in PD. Whether motor and cognitive circuits overlap in PD is unknown. In this article, we show that whereas motor performance improves in people with PD when on dopaminergic medication compared with off medication, perceptual decision-making based on previously learned information (priors) remains impaired whether on or off medications. To rule out effects of long-term DA treatment and dopaminergic neuronal loss such as occur in PD, we also tested a group of people with dopa-unresponsive focal dystonia, a disease that involves the basal ganglia, like PD, but has motor symptoms that are insensitive to dopamine treatment and is not thought to involve frontal cortical DA circuits, unlike PD. We found that people with focal dystonia showed intact perceptual decision-making performance but impaired use of priors in perceptual decision-making, similar to people with PD. Together, the results show a dissociation between motor and cognitive performance in people with PD and reveal a novel cognitive impairment, independent of sensory and motor impairment, in people with focal dystonia. The combined results from people with PD and people with focal dystonia provide mechanistic insights into the role of basal ganglia non-dopaminergic circuits in perceptual decision-making based on priors.
Comparative transcriptome analysis reveals conserved branching morphogenesis related genes involved in chamber formation of catfish swimbladder
Authors: Yang Yujia , Fu Qiang , Liu Yang , Wang Xiaozhu , Dunham Rex , Liu Shikai , Bao Lisui , Zeng Qifan , Zhou Tao , Li Ning , Qin Zhenkui , Jiang Chen , Gao Dongya , Liu Zhanjiang
Published: November 2017

The swimbladder is an internal gas-filled organ in teleosts. Its major function is to regulate buoyancy. The swimbladder exhibits great variation in size, shape, and number of compartments or chambers among teleosts. However, genomic control of swimbladder variation is unknown. Channel catfish ( Ictalurus punctatus), blue catfish ( Ictalurus furcatus), and their F1 hybrids of female channel catfish × male blue catfish (C × B hybrid catfish) provide a good model in which to investigate the swimbladder morphology, because channel catfish possess a single-chambered swimbladder, whereas blue catfish possess a bichambered swimbladder; C × B hybrid catfish possess a bichambered swimbladder but with a significantly reduced posterior chamber. Here we determined the transcriptional profiles of swimbladder from channel catfish, blue catfish, and C × B hybrid catfish. We examined their transcriptomes at both the fingerling and adult stages. Through comparative transcriptome analysis, ~4,000 differentially expressed genes (DEGs) were identified. Among these DEGs, members of the Wnt signaling pathway ( wnt1, wnt2, nfatc1, rac2), Hedgehog signaling pathway ( shh), and growth factors ( fgf10, igf-1) were identified. As these genes were known to be important for branching morphogenesis of mammalian lung and of mammary glands, their association with budding of the posterior chamber primordium and progressive development of bichambered swimbladder in fish suggest that these branching morphogenesis-related genes and their functions in branching are evolutionarily conserved across a broad spectrum of species.
Endothelial Cell Metabolism
Authors: Eelen Guy , de Zeeuw Pauline , Treps Lucas , Harjes Ulrike , Wong Brian W. , Carmeliet Peter
Published: November 2017

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are active players in the formation of new blood vessels (angiogenesis) both in health and (life-threatening) diseases. Recently, a new concept arose by which EC metabolism drives angiogenesis in parallel to well-established angiogenic growth factors (e.g., vascular endothelial growth factor). 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3-driven glycolysis generates energy to sustain competitive behavior of the ECs at the tip of a growing vessel sprout, whereas carnitine palmitoyltransferase 1a-controlled fatty acid oxidation regulates nucleotide synthesis and proliferation of ECs in the stalk of the sprout. To maintain vascular homeostasis, ECs rely on an intricate metabolic wiring characterized by intracellular compartmentalization, use metabolites for epigenetic regulation of EC subtype differentiation, crosstalk through metabolite release with other cell types, and exhibit EC subtype-specific metabolic traits. Importantly, maladaptation of EC metabolism contributes to vascular disorders, through EC dysfunction or excess angiogenesis, and presents new opportunities for anti-angiogenic strategies. Here we provide a comprehensive overview of established as well as newly uncovered aspects of EC metabolism.
Redox Regulation of Homeostasis and Proteostasis in Peroxisomes
Authors: Walker Cheryl L. , Pomatto Laura C. D. , Tripathi Durga Nand , Davies Kelvin J. A.
Published: November 2017

Peroxisomes are highly dynamic intracellular organelles involved in a variety of metabolic functions essential for the metabolism of long-chain fatty acids, d-amino acids, and many polyamines. A byproduct of peroxisomal metabolism is the generation, and subsequent detoxification, of reactive oxygen and nitrogen species, particularly hydrogen peroxide (H2O2). Because of its relatively low reactivity (as a mild oxidant), H2O2has a comparatively long intracellular half-life and a high diffusion rate, all of which makes H2O2an efficient signaling molecule. Peroxisomes also have intricate connections to mitochondria, and both organelles appear to play important roles in regulating redox signaling pathways. Peroxisomal proteins are also subject to oxidative modification and inactivation by the reactive oxygen and nitrogen species they generate, but the peroxisomal LonP2 protease can selectively remove such oxidatively damaged proteins, thus prolonging the useful lifespan of the organelle. Peroxisomal homeostasis must adapt to the metabolic state of the cell, by a combination of peroxisome proliferation, the removal of excess or badly damaged organelles by autophagy (pexophagy), as well as by processes of peroxisome inheritance and motility. More recently the tumor suppressors ataxia telangiectasia mutate (ATM) and tuberous sclerosis complex (TSC), which regulate mTORC1 signaling, have been found to regulate pexophagy in response to variable levels of certain reactive oxygen and nitrogen species. It is now clear that any significant loss of peroxisome homeostasis can have devastating physiological consequences. Peroxisome dysregulation has been implicated in several metabolic diseases, and increasing evidence highlights the important role of diminished peroxisomal functions in aging processes.
Improving Fourier Partial Sum Approximation for Discontinuous Functions Using a Weight Function
Authors: Yun Beong In
Published: November 2017

We introduce a generalized sigmoidal transformation wm(r;x) on a given interval [a,b] with a threshold at x=r∈(a,b). Using wm(r;x), we develop a weighted averaging method in order to improve Fourier partial sum approximation for a function having a jump-discontinuity. The method is based on the decomposition of the target function into the left-hand and the right-hand part extensions. The resultant approximate function is composed of the Fourier partial sums of each part extension. The pointwise convergence of the presented method and its availability for resolving Gibbs phenomenon are proved. The efficiency of the method is shown by some numerical examples.
Dexmedetomidine Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury by Suppressing TLR4-MyD88-NF-κB Signaling
Authors: Gao Jin-meng , Meng Xiao-wen , Zhang Juan , Chen Wei-rong , Xia Fan , Peng Ke , Ji Fu-hai
Published: November 2017

Objective. We previously reported that dexmedetomidine (DEX) offers cardioprotection against ischemia/reperfusion injury in rats. Here, we evaluated the role of toll-like receptors 4- (TLR4-) myeloid differentiation primary response 88- (MyD88-) nuclear factor-kappa B (NF-κB) signaling in DEX-mediated protection of cardiomyocytes usingin vitromodels of hypoxia/reoxygenation (H/R).Methods. The experiments were carried out in H9C2 cells and in primary neonatal rat cardiomyocytes. Cells pretreated with vehicle or DEX were exposed to hypoxia for 1 h followed by reoxygenation for 12 h. We analyzed cell viability and lactate dehydrogenase (LDH) activity and measured tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6), and IL-1βmRNA levels, TLR4, MyD88, and nuclear NF-κB p65 protein expression and NF-κB p65 nuclear localization. TLR4 knock-down by TLR4 siRNA transfection and overexpression by TLR4 DNA transfection were used to further confirm our findings.Results. DEX protected against H/R-induced cell damage and inflammation, as evidenced by increased cell survival rates, decreased LDH activity, and decreased TNF-α, IL-6, and IL-1βmRNA levels, as well as TLR4 and NF-κB protein expression. TLR4 knock-down partially prevented cell damage following H/R injury, while overexpression of TLR4 abolished the DEX-mediated protective effects.Conclusions. DEX pretreatment protects rat cardiomyocytes against H/R injury. This effect is partly mediated by TLR4 suppression via TLR4-MyD88-NF-κB signaling.
Inhibitory Activity of Ficus deltoidea var. trengganuensis Aqueous Extract on Lipopolysaccharide‐Induced TNF‐α Production from Microglia
Authors: Wang Huiling , Vidyadaran Sharmili , Mohd Moklas Mohamad Aris , Baharuldin Mohamad Taufik Hidayat
Published: November 2017

Objective. To explore the effect of Ficus deltoidea (FD) aqueous extracts on the release of tumor necrosis factor‐α (TNF‐α), the expression of CD40, and the morphology of microglial cells in lipopolysaccharide‐ (LPS‐) activated BV2 cells. Methods. The cytotoxicity of FD extract was assessed by MTS solution. BV2 cells were divided into 5 experimental groups, intervened, respectively, by FD (4 mg/mL) and LPS + FD (0, 1, 2, and 4 mg/mL). Besides, a blank control group was set up without any intervention. TNF‐α release was assessed by enzyme linked immunosorbent assay (ELISA). The expression of CD40 was examined by flow cytometry. Immunocytochemical staining was used to show the morphology of BV2 cells. Results. FD extract of different concentrations (1, 2, and 4 mg/mL) had no significant toxic effects on the BV2 cells. FD suppressed the activation of microglia in morphology and reduced TNF‐α production and expression of CD40 induced by LPS. Conclusion. FD extract has a therapeutic potential against neuroinflammatory diseases.
Evaluation of Energy Production and Energy Yield Assessment Based on Feasibility, Design, and Execution of 3 × 50 MW Grid-Connected Solar PV Pilot Project in Nooriabad
Authors: Jamil Irfan , Zhao Jinquan , Zhang Li , Jamil Rehan , Rafique Syed Furqan
Published: November 2017

The installation of 3 × 50 MW (150 MW DC) large utility scale solar power plant is ground based using ventilated polycrystalline module technology with fixed tilt angle of 28° in a 750-acre land, and the site is located about 115 km northeast of Karachi, Pakistan, near the town of ThanoBula Khan, Nooriabad, Sindh. This plant will be connected to the utility distribution system through a national grid of 220 kV outgoing double-loop transmission line. The 3 × 50 MW solar PV will be one of the largest tied grid-connected power projects as the site is receiving a rich average solar radiation of 158.7 kW/h/m2/month and an annual average temperature of about of 27°C. The analysis highlights the preliminary design of the case project such as feasibility study and PV solar design aspects and is based on a simulation study of energy yield assessment which has all been illustrated. The annual energy production and energy yield assessment values of the plant are computed using the PVSYST software. The assumptions and results of energy losses, annual performance ratio (PR) 74.73%, annual capacity factor 17.7%, and annual energy production of the plant at 232,518 MWh/year are recorded accordingly. Bear in mind that reference recorded data indicates a good agreement over the performance of the proposed PV power plant.