bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterisation and outcomes of different subsets of low disease activity states in patients with systemic lupus erythematosus
Authors: Hao Yanjie , Hansen Dylan , Louthrenoo Worawit , Chen Yi-Hsing , Cho Jiacai , Lateef Aisha , Hamijoyo Laniyati , Luo Shue-Fen , Wu Yeong-Jian Jan , Navarra Sandra , Zamora Leonid , Li Zhanguo , Sockalingam Sargunan , Katsumata Yasuhiro , Harigai Masayoshi , Zhang Zhuoli , Chan Madelynn , Kikuchi Jun , Takeuchi Tsutomu , Bae Sang-Cheol , Goldblatt Fiona , O’Neill Sean , Ng Kristine , Basnayake B M D B , Tugnet Nicola , Tanaka Yoshiya , Lau Chak Sing , Li Ning , Golder Vera , Hoi Alberta , Kandane-Rathnayake Rangi , Morand Eric , Oon Shereen , Nikpour Mandana
Published: September 2024

Objectives

The lupus low disease activity state (LLDAS) allows for certain clinical and/or serological activity of SLE, provided overall disease activity does not exceed predefined cut-offs. This study aimed to evaluate the outcomes of patients who achieved LLDAS with clinical activity, serological activity only or neither clinical nor serological activity.

Methods

Patients with SLE enrolled in a prospective multinational cohort from March 2013 to December 2020 who were in LLDAS at least once were included. Visits that fulfilled both LLDAS and Definition of Remission in SLE (DORIS) criteria were excluded.

Results

2099 patients were included, with median follow-up of 3.5 (IQR 1.3–5.8) years. At 6150 visits, patients were in LLDAS but not DORIS criteria; of these 1280 (20.8%) had some clinical activity, 3102 (50.4%) visits had serological activity only and 1768 (28.8%) visits had neither clinical nor serological activity. Multivariable regression analysis showed that compared with non-LLDAS, all three subsets of LLDAS had a protective association with flares in the ensuing 6 months and damage accrual in the ensuing 36 months. LLDAS with no clinical or serological activity had a significantly stronger protective association with severe flares in the ensuing 6 months compared with LLDAS with clinical activity (HR 0.47, 95% CI (0.27 to 0.82), p=0.007).

Conclusions

LLDAS without any clinical activity accounted for almost 80% of LLDAS visits. This study confirms that all subsets of LLDAS are associated with reduced flare and damage accrual. However, LLDAS without any clinical or serological activity has the strongest protective association with severe flares.
The roles of rabies virus structural proteins in immune evasion and implications for vaccine development
Authors: Wang Pei-Hua , Xing Li
Published: September 2024

Rabies is a zoonotic infectious disease that targets the nervous system of human and animals and has about 100% fatality rate without treatment. Rabies virus is a bullet-like viral particle composed of five structural proteins, including nucleoprotein (N), phosphorylated protein (P), matrix protein (M), glycoprotein (G), and large subunit (L) of RNA-dependent RNA polymerase. These multifunctional viral proteins also play critical roles in the immune escape by inhibiting specific immune responses in the host, resulting in massive replication of the virus in the nervous system and abnormal behaviors of patients such as brain dysfunction and hydrophobia, which ultimately lead to the death of patients. Herein, the role of five structural proteins of rabies virus in the viral replication and immune escape and its implication for the development of vaccines were systemically reviewed, so as to shed light on the understanding of pathogenic mechanism of rabies virus.
Ideal free distributions form across a regulatory boundary in the Northwest Atlantic Fisheries Organization (NAFO) Division 4X and 5Z groundfish fisheries
Authors: Enright D.T. , Comeau P. , Gillis D.M.
Published: September 2024

We used isodars, developed from the ideal free distribution (IFD), to predict the distribution of fishing effort across regulatory boundaries in the south-western Scotian Shelf’s haddock fishery. Our analysis was focused around the boundary between Northwest Atlantic Fisheries Organization’s Divisions 4X and 5Z. While effort within 4X was related to the standardized catch value and effort experienced along the 4X–5Z boundary, most effort predictions across the boundary were also accurate. Accuracy of these cross-boundary isodars suggests that a high degree of movement across the boundary meets the IFD assumption of free movement and thus, effort on one side of the boundary is related to fishing success on the other side of the boundary. Fisheries management strategies should adopt a broad view that encompasses adjacent regulatory regions to understand where vessels may choose to fish when multiple regulatory regions are accessible. In fisheries where isodars describe effort distributions across a regulatory boundary, the relative abundance of the underlying fish population could be better indicated by effort distribution among regulatory regions than by catch rates.
EdgeSyn: Privacy-preserving Data Publishing on Edge Network over Infinite Multimedia Data Stream
Authors: Tan Chang , Liu Zhewei , Li Zhengdao , Jia Jingyu , Lv Siyi , Li Tong , Liu Zheli
Published: September 2024

To privately publish sensitive multimedia data in an edge network with fog devices, one of the best privacy-preserving solutions is to use differential privacy (DP) mechanisms. However, existing DP data publication mechanisms for the infinite data stream of edge networks mainly focus on publishing data with specific types of data or a set of predetermined queries. This approach is not suitable for multimedia data with numerous features that require a more flexible data publishing mechanism. In this paper, we propose EdgeSyn, a novel mechanism for accurately publishing multimedia data over infinite data streams in an edge network. It allocates privacy budgets with a sliding window, adopting data synthesis mechanisms to support dynamic publishing without loss of accuracy. In more detail, EdgeSyn addresses the limitations associated with data types in prior data stream publishing approaches and introduces a privacy budget management strategy that optimally allocates budgets for the implementation of data synthesis mechanisms over an infinite data stream. The experimental results show that EdgeSyn performs well under different privacy budgets and various lengths of active windows.
Acute cardiovascular responses to the 100-mi Western States Endurance Run
Authors: Babcock Matthew C. , El-Kurd Omar B. , Bagley James R. , Linder Braxton A. , Stute Nina L. , Jeong Soolim , Vondrasek Joseph D. , Watso Joseph C. , Robinson Austin T. , Grosicki Gregory J.
Published: September 2024

Ultramarathon participation is growing in popularity and exposes runners to unique stressors including extreme temperatures, high altitude, and exceedingly long exercise duration. However, the acute effects of ultramarathon participation on the cardiovascular system are not well understood. To determine the acute effects of trail ultramarathon participation on central artery stiffness and hemodynamics, 41 participants (9 F, 32 M) participating in the 2023 Western States Endurance Run underwent measures of carotid-femoral pulse wave velocity (cf-PWV) and pulse wave analysis pre- and <1 h post-race. Subendocardial viability ratio (SEVR) was calculated from central blood pressure (BP) waveforms. Serum was analyzed for creatine kinase (CK) activity as a measure of muscle damage. Normally distributed data are presented as means ± standard deviation (SD), and nonnormally distributed data are presented as median (interquartile range). Runners were middle-aged and generally lean [age = 44 ± 9 yr, body mass index (BMI) = 22.7 ± 1.8 kg·m−2]. There was no difference in cf-PWV from pre- to post-race (pre = 6.4 ± 1.0, post = 6.2 ± 0.85 m/s, P = 0.104), a finding that persisted after adjusting for mean arterial pressure ( P = 0.563). Systolic and diastolic BPs were lower post-race (pre = 129/77 ± 9/7, post = 122/74 ± 10/8 mmHg, P < 0.001). Augmentation index (AIx; pre = 17.3 ± 12.2, post = 6.0 ± 13.7%, P < 0.001), AIx normalized to a heart rate of 75 beats/min ( P = 0.043), reflection magnitude (pre = 55.5(49.0–60.8), post = 45.5(41.8–48.8)%, P < 0.001), and SEVR (pre = 173.0(158.0–190.0), post = 127.5(116.5–145.8)%, P < 0.001) were reduced post-race. CK increased markedly from pre- to post-race (pre = 111(85–162), post = 11,973(5,049–17,954) U/L, P < 0.001). Completing a 161-km trail ultramarathon does not affect central arterial stiffness and acutely reduces BP despite eliciting profound muscle damage. However, the reduced post-race SEVR suggests a short-term mismatch between myocardial work and coronary artery perfusion.

NEW AND NOTEWORTHY Ultramarathon participation is growing dramatically. However, the acute cardiovascular effects of completing a 161-km trail ultramarathon remain unknown. We examined the acute effects of completing the 2023 Western States Endurance Run on arterial stiffness and central hemodynamics in a relatively large sample of males and females. We observed dramatic postexercise hypotension, reductions in reflected wave amplitude and reduced subendocardial viability ratio post-race. These findings suggest that ultramarathon participation has few negative effects on cardiovascular health.
DarkOnto: An Ontology Construction Approach for Dark Web Community Discussions Through Topic Modeling and Ontology Learning
Authors: Basheer Randa , Alkhatib Bassel
Published: September 2024

Social networks on the dark web are rich in data that provides valuable insight into the nature of the activities on the dark web and human behaviors related to these activities. It also encompasses a diversity of ideologies, interests, and thought patterns associated with illicit activities and businesses on the dark web. For this reason, social networks on the dark web constitute a powerful tool and a profuse data source for various investigative work. However, such investigations encounter considerable challenges related to the massive volumes of textual data, analyzing it effectively, and extracting knowledge from it. This knowledge can be used in various investigations and studies when representing it in ontologies as a unified and integrative data source. In this paper, we introduce a novel approach for extracting and representing knowledge hidden in dark web communities through topic modeling and ontology learning methods. We start from the conceptual design of the ontology and employ several stages of text processing and analysis to achieve the desired knowledge graph, DarkOnto. These stages include data cleaning and preprocessing, topic modeling using correlated topic model (CTM), class‐topic similarity estimation, ontology construction, ontology population, and ontology evaluation, where the proposed approach achieved high results. Furthermore, we discuss the results, limitations, challenges, and future work. This paper presents a promising approach for extracting hidden valuable knowledge from dark web communities where investigating and conceptualizing criminal communities can be conducted efficiently.
Supplementary Table 8 from The Proteogenomics of Prostate Cancer Radioresistance
Authors: Haas Roni , Frame Gavin , Khan Shahbaz , Neilsen Beth K. , Hong Boon Hao , Yeo Celestia P.X. , Yamaguchi Takafumi N. , Ong Enya H.W. , Zhao Wenyan , Carlin Benjamin , Yeo Eugenia L.L. , Tan Kah Min , Bugh Yuan Zhe , Zhu Chenghao , Hugh-White Rupert , Livingstone Julie , Poon Dennis J.J. , Chu Pek Lim , Patel Yash , Tao Shu , Ignatchenko Vladimir , Kurganovs Natalie J. , Higgins Geoff S. , Downes Michelle R. , Loblaw Andrew , Vesprini Danny , Kishan Amar U. , Chua Melvin L.K. , Kislinger Thomas , Boutros Paul C. , Liu Stanley K.
Published: September 2024

Differentially abundant miRNAs
Supplementary Table 7 from The Proteogenomics of Prostate Cancer Radioresistance
Authors: Haas Roni , Frame Gavin , Khan Shahbaz , Neilsen Beth K. , Hong Boon Hao , Yeo Celestia P.X. , Yamaguchi Takafumi N. , Ong Enya H.W. , Zhao Wenyan , Carlin Benjamin , Yeo Eugenia L.L. , Tan Kah Min , Bugh Yuan Zhe , Zhu Chenghao , Hugh-White Rupert , Livingstone Julie , Poon Dennis J.J. , Chu Pek Lim , Patel Yash , Tao Shu , Ignatchenko Vladimir , Kurganovs Natalie J. , Higgins Geoff S. , Downes Michelle R. , Loblaw Andrew , Vesprini Danny , Kishan Amar U. , Chua Melvin L.K. , Kislinger Thomas , Boutros Paul C. , Liu Stanley K.
Published: September 2024

Normalized transcript counts
Supplementary Table 6 from The Proteogenomics of Prostate Cancer Radioresistance
Authors: Haas Roni , Frame Gavin , Khan Shahbaz , Neilsen Beth K. , Hong Boon Hao , Yeo Celestia P.X. , Yamaguchi Takafumi N. , Ong Enya H.W. , Zhao Wenyan , Carlin Benjamin , Yeo Eugenia L.L. , Tan Kah Min , Bugh Yuan Zhe , Zhu Chenghao , Hugh-White Rupert , Livingstone Julie , Poon Dennis J.J. , Chu Pek Lim , Patel Yash , Tao Shu , Ignatchenko Vladimir , Kurganovs Natalie J. , Higgins Geoff S. , Downes Michelle R. , Loblaw Andrew , Vesprini Danny , Kishan Amar U. , Chua Melvin L.K. , Kislinger Thomas , Boutros Paul C. , Liu Stanley K.
Published: September 2024

Fusion transcript events
Supplementary Table 11 from The Proteogenomics of Prostate Cancer Radioresistance
Authors: Haas Roni , Frame Gavin , Khan Shahbaz , Neilsen Beth K. , Hong Boon Hao , Yeo Celestia P.X. , Yamaguchi Takafumi N. , Ong Enya H.W. , Zhao Wenyan , Carlin Benjamin , Yeo Eugenia L.L. , Tan Kah Min , Bugh Yuan Zhe , Zhu Chenghao , Hugh-White Rupert , Livingstone Julie , Poon Dennis J.J. , Chu Pek Lim , Patel Yash , Tao Shu , Ignatchenko Vladimir , Kurganovs Natalie J. , Higgins Geoff S. , Downes Michelle R. , Loblaw Andrew , Vesprini Danny , Kishan Amar U. , Chua Melvin L.K. , Kislinger Thomas , Boutros Paul C. , Liu Stanley K.
Published: September 2024

Top target genes used for clinical associations
Supplementary Table 10 from The Proteogenomics of Prostate Cancer Radioresistance
Authors: Haas Roni , Frame Gavin , Khan Shahbaz , Neilsen Beth K. , Hong Boon Hao , Yeo Celestia P.X. , Yamaguchi Takafumi N. , Ong Enya H.W. , Zhao Wenyan , Carlin Benjamin , Yeo Eugenia L.L. , Tan Kah Min , Bugh Yuan Zhe , Zhu Chenghao , Hugh-White Rupert , Livingstone Julie , Poon Dennis J.J. , Chu Pek Lim , Patel Yash , Tao Shu , Ignatchenko Vladimir , Kurganovs Natalie J. , Higgins Geoff S. , Downes Michelle R. , Loblaw Andrew , Vesprini Danny , Kishan Amar U. , Chua Melvin L.K. , Kislinger Thomas , Boutros Paul C. , Liu Stanley K.
Published: September 2024

Protein intensities
Supplementary Figure 5 from The Proteogenomics of Prostate Cancer Radioresistance
Authors: Haas Roni , Frame Gavin , Khan Shahbaz , Neilsen Beth K. , Hong Boon Hao , Yeo Celestia P.X. , Yamaguchi Takafumi N. , Ong Enya H.W. , Zhao Wenyan , Carlin Benjamin , Yeo Eugenia L.L. , Tan Kah Min , Bugh Yuan Zhe , Zhu Chenghao , Hugh-White Rupert , Livingstone Julie , Poon Dennis J.J. , Chu Pek Lim , Patel Yash , Tao Shu , Ignatchenko Vladimir , Kurganovs Natalie J. , Higgins Geoff S. , Downes Michelle R. , Loblaw Andrew , Vesprini Danny , Kishan Amar U. , Chua Melvin L.K. , Kislinger Thomas , Boutros Paul C. , Liu Stanley K.
Published: September 2024

RNA-protein relationships
Figure 4 from The Proteogenomics of Prostate Cancer Radioresistance
Authors: Haas Roni , Frame Gavin , Khan Shahbaz , Neilsen Beth K. , Hong Boon Hao , Yeo Celestia P.X. , Yamaguchi Takafumi N. , Ong Enya H.W. , Zhao Wenyan , Carlin Benjamin , Yeo Eugenia L.L. , Tan Kah Min , Bugh Yuan Zhe , Zhu Chenghao , Hugh-White Rupert , Livingstone Julie , Poon Dennis J.J. , Chu Pek Lim , Patel Yash , Tao Shu , Ignatchenko Vladimir , Kurganovs Natalie J. , Higgins Geoff S. , Downes Michelle R. , Loblaw Andrew , Vesprini Danny , Kishan Amar U. , Chua Melvin L.K. , Kislinger Thomas , Boutros Paul C. , Liu Stanley K.
Published: September 2024

Characteristics of radioresistance modulator candidates in primary prostate tumors. A, Significant associations (FDR ≤ 0.05) between CNAs in candidate genes and biochemical recurrence, as shown by fitting Cox proportional hazard models in ICGC. B,POLQ amplification is associated with biochemical relapse in ICGC (Cox proportional hazard model; FDR = 7.78 × 10−3). C, High POLQ RNA abundance is associated with BCR following an RT treatment in NCCS (Cox proportional hazard model; P = 0.06). D, Increased RNA abundance of POLQ is associated with a high mutation ratio in clinically relevant candidate genes based on linear regression in ICGC. Padjusted levels after FDR correction are presented on the (right). E, Significant correlations between RNA abundances of clinically relevant candidates and POLQ RNA abundance. F and G, Strong correlation between POLQ and BRCA2 RNA abundance in ICGC (F) and NCCS (G). H, Increased RNA abundance of POLQ is associated with high Gleason grades. In F–H, ρ: Spearman correlation. Pρ: the Padjusted after FDR.
Figure 3 from The Proteogenomics of Prostate Cancer Radioresistance
Authors: Haas Roni , Frame Gavin , Khan Shahbaz , Neilsen Beth K. , Hong Boon Hao , Yeo Celestia P.X. , Yamaguchi Takafumi N. , Ong Enya H.W. , Zhao Wenyan , Carlin Benjamin , Yeo Eugenia L.L. , Tan Kah Min , Bugh Yuan Zhe , Zhu Chenghao , Hugh-White Rupert , Livingstone Julie , Poon Dennis J.J. , Chu Pek Lim , Patel Yash , Tao Shu , Ignatchenko Vladimir , Kurganovs Natalie J. , Higgins Geoff S. , Downes Michelle R. , Loblaw Andrew , Vesprini Danny , Kishan Amar U. , Chua Melvin L.K. , Kislinger Thomas , Boutros Paul C. , Liu Stanley K.
Published: September 2024

Fractionation-dependent protein profiles in radioresistant cells. A, The difference in relationships of consensus-module eigengenes and cellular fractions between CF- and HF-resistant cells. The colors represent the difference in correlations between consensus module eigengenes and a specific subcellular fraction of HF-resistant cells compared to CF: Blue, a higher correlation in CF-resistant cells; Red, a higher correlation in HF-resistant cells. At the top, each color represents a module, which is a detected group of positively correlated genes that are highly interconnected. B, Gene ontology enrichment of module genes for biological processes. The top two enrichments for each module are presented. C, Differences in protein abundances of driver, across different subcellular fractions and in whole cell lysates. Main, protein Cohen’s d effect sizes of significant proteins across cell fractions. Only significant changes at the level of FDR ≤ 0.025 were plotted. The dot color is the directionality: magenta and green represent upregulation and downregulation, respectively, toward CF- or HF-resistant cells. Right, the consensus modules that each gene was assigned to. For all figures, three replicates were used for CF- and HF- resistant cells. For the parental cells, at least two replicates were used.
Figure 2 from The Proteogenomics of Prostate Cancer Radioresistance
Authors: Haas Roni , Frame Gavin , Khan Shahbaz , Neilsen Beth K. , Hong Boon Hao , Yeo Celestia P.X. , Yamaguchi Takafumi N. , Ong Enya H.W. , Zhao Wenyan , Carlin Benjamin , Yeo Eugenia L.L. , Tan Kah Min , Bugh Yuan Zhe , Zhu Chenghao , Hugh-White Rupert , Livingstone Julie , Poon Dennis J.J. , Chu Pek Lim , Patel Yash , Tao Shu , Ignatchenko Vladimir , Kurganovs Natalie J. , Higgins Geoff S. , Downes Michelle R. , Loblaw Andrew , Vesprini Danny , Kishan Amar U. , Chua Melvin L.K. , Kislinger Thomas , Boutros Paul C. , Liu Stanley K.
Published: September 2024

Transcriptomic signatures of cancer-related genes in radioresistant cells. A, The differences in RNA abundances of driver cancer genes. The most abundant transcript out of all transcripts per gene was taken for visualization. B–C, The differences in RNA abundances of affected driver gene, compared to their abundance differences at the protein level. B, Differences between CF-resistant cells and the parental cells. C, Differences between HF-resistant cells and the parental cells. D, The RNA abundance profile of cancer hallmark genes in CF-resistant cells is distinct from HF-resistant cells and the parental profiles, which are relatively similar. The heatmap presents normalized counts of RNA isoforms that were significantly differentially abundant in CF-resistant cells compared to HF. Red, high abundance; blue, low abundance. For visualization, RNA abundances as a function of log10 were converted to z-scores. E, Enrichment analysis of hallmark gene sets. The dot size represents the enrichment score and the dot color represents the directionality: for CF vs. PAR, HF vs. PAR, and HF vs. CF tests, orange represents upregulation toward CF-resistant cells, HF-resistant cells, and HF-resistant cells. F, The differences in RNA abundances of the lncRNA UCA1, the miRNAs 200c-3P and 200b-3P, and ZEB2 (the target of the miRNAs 200c-3P and 200b-3P). For UCA1 transcripts, the small letters represent different isoforms. In A and F, the dot size represents the log2 (fold change) size and the dot color represents the directionality: for CF vs. PAR, HF vs. PAR, and HF vs. CF tests, red represents upregulation toward CF-resistant cells, HF-resistant cells, and HF-resistant cells. For all figures , three RNA-seq replicates were used for the radioresistant cell lines and two for the parental line. In B–C, three replicates were used for all cell types.
Figure S2 from Exosomal Thomsen–Friedenreich Glycoantigen: A New Liquid Biopsy Biomarker for Lung and Breast Cancer Diagnoses
Authors: Hsu Chang-Chieh , Su Yafei , Rittenhouse-Olson Kate , Attwood Kristopher M. , Mojica Wilfrido , Reid Mary E. , Dy Grace K. , Wu Yun
Published: September 2024

Supplementary Figure S2. SPR assay demonstrated exosomes carry TF-Ag-α. Exosomes were isolated from cancer patient serum samples using both total exosome isolation kit (from serum) (ThermoFisher) and exoRNeasy midi kit (Qiagen). Significantly higher levels of TF-Ag-α were observed in exosome samples isolated using both kits than the exosome-depleted serum samples. The exosome concentration was 3.29x10^11 exosomes/mL.
Real-World Study of Systemic Treatment after First-Line Atezolizumab plus Bevacizumab for Hepatocellular Carcinoma in Asia-Pacific Countries
Authors: Lee Choong-kun , Yoo Changhoon , Hong Jung Yong , Park Se Jun , Kim Jin Won , Tai David Wai Meng , Kim Hyeyeong , Korphaisarn Krittiya , Tanasanvimon Suebpong , Chen San-Chi , Kim Ju Won , Kim Ilhwan , Kim Moonho , Choo Joan , Oh Sang-Bo , Chen Ching-Tso , Bae Woo Kyun , Kim Hongsik , Huh Seok Jae , Yen Chia-Jui , Park Sejung , Lee Dong Ki , Chan Landon Long , Kang Beodeul , Kang Minsu , Sundar Raghav , Choi Hye Jin , Chan Stephen Lam , Chon Hong Jae , Lee Myung-Ah
Published: September 2024

Introduction: Atezolizumab plus bevacizumab is a commonly used first-line regimen for advanced hepatocellular carcinoma (HCC) treatment owing to its superior outcomes compared to sorafenib. However, optimal subsequent treatment options for patients with HCC who progressed on first-line atezolizumab plus bevacizumab remain unclear. Methods: This multinational, multi-institutional, retrospective study included patients with HCC from 22 centers in five Asia-Pacific countries who were treated with first-line atezolizumab plus bevacizumab, which was discontinued for any reason. The endpoints included progression-free survival (PFS) and overall survival (OS) according to patient characteristics and second-line regimens. Results: Between June 2016 and May 2023, 1,141 patients were treated with first-line atezolizumab plus bevacizumab, of whom 629 (55.1%) received subsequent treatment. Sorafenib and lenvatinib were the most commonly administered second-line regimens (53.9% and 25.6%, respectively). Overall, the median PFS and OS were 2.9 and 8.0 months, respectively. Lenvatinib had longer PFS (4.0 vs. 2.3 months) and OS (8.0 vs. 6.3 months) than sorafenib. Patients treated with tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI) (n = 50, 8.3%) showed PFS and OS of 5.4 and 12.6 months, respectively. Lower tumor burden and lenvatinib or TKI plus ICI use were associated with longer second-line PFS. Preserved liver function was associated with improved OS. Conclusions: In patients with HCC who progressed on first-line atezolizumab plus bevacizumab, sorafenib and lenvatinib were the most commonly used second-line regimens in Asia-Pacific countries, with lenvatinib resulting in longer OS than sorafenib. The second-line TKI plus ICI combination exhibited promising efficacy, suggesting the potential role of continuing ICIs beyond disease progression.
Baicalin Attenuates Type 2 Immune Responses in a Mouse Allergic Asthma Model through Inhibiting the Production of Thymic Stromal Lymphopoietin
Authors: Zeng Zhisen , Ruan Yaoxin , Ying Haoran , Wang Jie , Wang Huangbin , Chen Shuzhen
Published: September 2024

Introduction: Baicalin is a flavonoid chemical extracted and purified from the traditional Chinese medicine named Scutellaria baicalensis Georgi, which possesses broad pharmacological properties. Our work aimed to explore the protective role of baicalin in allergic asthma and its potential mechanisms on regulating type 2 immune response. Methods: Mice were injected intraperitoneally with ovalbumin (OVA) twice, further challenged with OVA aerosol for continuous 5 days. For baicalin group, mice were pre-administrated with baicalin. After the final challenge, the immune cells in bronchoalveolar lavage fluid (BALF) and blood were examined. The cytokines were evaluated by ELISA. Histological inspections were examined by hematoxylin and eosin staining and Periodic Acid-Schiff staining. Thymic stromal lymphopoietin (TSLP) expression in lungs were detected using immunohistochemistry and Western blotting. Results: The eosinophils infiltrating in BALF were reduced remarkably in baicalin-treated asthmatic mice. Baicalin decreased OVA-induced inflammatory cytokines and total serum immunoglobulin E secretion significantly. Moreover, baicalin alleviated the asthmatic pathological changes and substantially suppressed TSLP expression in the lung tissues. Conclusion: Our study indicates that baicalin attenuates OVA-induced allergic asthma in mice effectively by suppressing type 2 immune responses, which might provide a novel insight into the anti-asthmatic activity of baicalin.
Severe Nodulocystic Acne Induced by Mercury-Containing Skin-Whitening Cream: A Case Report and Call for Public Awareness
Authors: Alsuwaidan Sami , Nagshabandi Khalid Nabil , Alajlan Abdulmajeed
Published: September 2024

Introduction: Skin-whitening products, often containing mercury, are used worldwide for cosmetic purposes but pose significant health risks. Mercury, a melanotoxin, can cause severe dermatological, renal, and neurological complications. Case Presentation: We report the case of a 27-year-old woman who developed severe nodulocystic acne due to chronic use of a mercury-containing skin-whitening cream. Treatment with isotretinoin and prednisolone led to significant improvement within 3 months. Conclusion: This case underscores the need for public awareness and stricter regulatory actions to prevent mercury-related health hazards from skin-whitening products.
Recurrent Bilateral Chronic Central Serous Chorioretinopathy Treated with Anti-VEGF
Authors: Atisundara Siti Mutia , Iskandar Erwin
Published: September 2024

Introduction: After diabetic retinopathy, branch retinal vein occlusion, and age-related macular degeneration, central serous chorioretinopathy (CSC) is the fourth most frequent retinopathy. Males in their 20s to 50s who have acute or subacute central vision loss or distortion are usually the ones who develop CSC, males more than females. Localized serous macula detachment is its defining feature. Within three to six months, the majority of instances resolve on their own and return to normal vision, but in certain situations, laser or medication treatment may be necessary.
Case: A 45-year-old male came with a chief complaint of gradually blurred vision in his right eye since a month ago. Optical computed tomography (OCT) examination showed an accumulation of sub-retinal fluid (SRF) suggestive of CSC. His visual acuity was declining even after being given oral spironolactone for 1 month, so he was scheduled for intravitreal injection Anti-Vascular Endothelial Growth Factor Therapy (Anti-VEGF). After three times in injection right eye the visual acuity improved. One month later he had a chief complaint of gradually blurred vision in his left eye. After three times in injection left eye, CSC in both eyes resolved and the visual acuity improved. Three years later he came back with a chief complaint on both eyes like three years ago.
Conclusion: Normally resolution of symptoms from CSC takes several months, treatment with anti- VEGF injection an efficient way to treat CSC resolution time and improve vision.
eRST: A Signaled Graph Theory of Discourse Relations and Organization
Authors: Zeldes Amir , Aoyama Tatsuya , Liu Yang Janet , Peng Siyao , Das Debopam , Gessler Luke
Published: September 2024

In this article we present Enhanced Rhetorical Structure Theory (eRST), a new theoretical framework for computational discourse analysis, based on an expansion of Rhetorical Structure Theory (RST). The framework encompasses discourse relation graphs with tree-breaking, non-projective and concurrent relations, as well as implicit and explicit signals which give explainable rationales to our analyses. We survey shortcomings of RST and other existing frameworks, such as Segmented Discourse Representation Theory, the Penn Discourse Treebank, and Discourse Dependencies, and address these using constructs in the proposed theory. We provide annotation, search, and visualization tools for data, and present and evaluate a freely available corpus of English annotated according to our framework, encompassing 12 spoken and written genres with over 200K tokens. Finally, we discuss automatic parsing, evaluation metrics, and applications for data in our framework.
Socio-psychological features of the ethnic identity of Russians living in Azerbaijan
Authors: Guliev Tamerlan F. , Malysheva Natalia G.
Published: September 2024

Background. Ethnic identity is an important factor in the interaction of different cultures. Studying an ethnic group that lives outside its historical homeland allows to better understand the role that living in a foreign cultural environment plays in the feeling of belonging to one's people. Objectives. The study had its purpose to analyze the socio-psychological characteristics of the ethnic identity of Russians living in Azerbaijan compared with Russians living in Russia and Azerbaijanis living in Azerbaijan. Study Participants. The study involved 185 respondents (71 Russians living in Azerbaijan, 76 Azerbaijanis living in Azerbaijan, and 38 Russians living in Russia) aged 18 to 70 (M = 34,2; SD = 15,8). Methods. The survey included the authors’ questionnaire and J. Phinney’s inventory (MEIM) adapted by A.M. Arbitailo. The processing methods implemented the Mann — Whitney U test, Pearson chi-square, Fisher's phi test, and content analysis of open questions. Results. The study results show that ethnic identity level among Russians in Azerbaijan is lower than among Russians in Russia, which may be due to the influence of Azerbaijani culture and assimilation processes. It was also found that ethnic identity of Russians in Azerbaijan often includes elements of local culture, which supports the assumption of conglomeration processes. An analysis of perception of cultural archetypes and ethno-differentiating features among Russians and Azerbaijanis indicates differences in the perception of cultural and ethnic characteristics, which emphasizes the complexity of the processes of integration and identification in multicultural setting. Conclusions. The ethnic identity of Russians in Azerbaijan is characterized by a lower level of expression and assimilation of some elements of Azerbaijani culture in its cognitive component. However, the differences in behavioral patterns and values indicate the formation of a conglomerate identity, where ethnic, linguistic, and national identities interact though do not completely merge.
Unity and Hostility
Authors: Davila E.J.
Published: September 2024

This article utilizes narrative-critical analysis to examine the ten appearances of the adverb ὁμοθυμαδόν (“with one accord/purpose/impulse”) in the book of Acts. By situating each use of the adverb within the structure and plot of Acts, this article contends that Luke uses the adverb to characterize two distinct collective bodies—the church and its adversaries—and to exhort his audience toward unified perseverance amidst rising hostility.
“Agricultural to Non-agricultural” Ways and Chinese Labor Market Differentiation: Endowment Difference or Identity Discrimination?
Authors: Ren Yuzhuo , Zheng Linhao , Dai Wei , Cheng Mengyao
Published: September 2024

Different methods of transforming rural migrants’ household registration can affect their integration into citizenship. This study assesses the impact of different rural-to- urban hukou conversion methods on labor market wages and job entry, utilizing empirical analysis with China General Social Survey (CGSS) data. Rural migrants transitioning to urban hukou are categorized as active or passive “agricultural to non-agricultural” groups. Wage disparities between these groups are analyzed using the Oaxaca-Blinder decomposition method, revealing that 50% of the wage gap remains unexplained by individual characteristics. Additionally, this paper explores factors contributing to wage and job entry differences using OLS regression analysis. Empirical findings indicate that discrimination significantly contributes to the wage and job entry gap between passive and active groups, with primary mechanisms including statistical bias, information acquisition differences, and identity challenges. These results underscore the inevitable transition of the agricultural population to urban areas in emerging nations’ development trajectory. However, challenges may arise during this transformation, particularly in China, where passive “agricultural to non-agricultural” individuals face discrimination. Addressing the rights and interests of this group is crucial for ensuring smooth urbanization in China and offers insights to improve urbanization efforts in developing nations.
A new species within the Enteromius kerstenii complex (Actinopterygii, Cyprinidae, Smiliogastrinae) from south-western Ethiopia
Authors: ENGLMAIER GERNOT K. , CHAI MIN , WUBIE ALEMAYEHU , COLLINS RUPERT A. , GETAHUN ABEBE
Published: September 2024

A new species of small-sized smiliogastrin barb, Enteromius gamo sp. nov., is described from tributaries to lakes Abaya and Chamo in south-western Ethiopia. The new species belongs to a readily diagnosable group commonly identified as E. kerstenii, exhibiting a thickened and serrated last unbranched ray in the dorsal fin, a low number of scales in the lateral series (≤ 27), and a yellow, orange or reddish blotch on operculum. Pairwise genetic distances between the new species from Ethiopia and specimens of E. kerstenii from close to the type locality in north-eastern Tanzania were 7.5–8.3 % (COI) and 8.9–10.1 % (cytb). Enteromius gamo sp. nov. is morphologically distinguished from E. kerstenii and all examined congeners from Tanzania, Kenya, and Uganda primarily by short anterior (15.8–35.1 %, mean 27.4 %, of snout length) and posterior (63.2–95.7 %, mean 81.0 %, of snout length) barbels. The new species is known only from wetlands and side channels of rivers (Hare, Sile, and Sago) along the western shores of lakes Abaya and Chamo.
Morphology and taxonomic significance of the labrum in the flea beetle genus Chaetocnema Stephens, 1831 (Coleoptera, Chrysomelidae, Galerucinae, Alticini)
Authors: MATHEW SANDRA MARIA , PRATHAPAN K. D.
Published: September 2024

The structure of labrum or upper lip in adult Coleoptera is only minimally investigated and used in classification and phylogeny. This study investigates the morphology of the labrum in the flea beetle genus Chaetocnema Stephens, 1831 (Chrysomelidae, Galerucinae, Alticini) to assess and develop a terminology and identify potential morphological characters useful to delimitation of species and species groups as well as phylogeny reconstruction in leaf beetles.
Crowdfunding Success for Female Versus Male Entrepreneurs Depends on Whether a Consumer Versus Investor Decision Frame Is Salient
Authors: Gao Huachao , Wang Xin (Shane) , Li Xi , Cotte June
Published: September 2024

Ensuring equal access to entrepreneurship and startup funding for both female and male entrepreneurs is crucial for societal perceptions of justice and long-term prosperity. Previous research presents contrasting findings, with some studies indicating a male advantage and others suggesting a female advantage. This research reconciles these inconsistencies by identifying the decision frame as a moderator. Specifically, in crowdfunding contexts, a consumer decision frame leads to stronger reliance on communal evaluation norms, resulting in favoring female entrepreneurs who are perceived as more disadvantaged. Conversely, an investor decision frame leads to stronger reliance on exchange evaluation norms, resulting in favoring male entrepreneurs who are perceived as more determined/passionate. Based on this, the authors propose that the strategic use of an entrepreneur's profile, activating a specific evaluation norm, and showing crowdfunding dependence attenuate the differential support for female versus male entrepreneurs, resulting in equal support for both. Results from six studies using a multimethod design provide converging support for this framework. This research is the first to differentiate between and directly compare consumer and investor decision frames, advancing the related literature and offering valuable guidelines for entrepreneurs, funding platforms, and public policy makers.
Impact of a Ball Regulation Change on Game Performance and Shooting Play in Japanese U-15 Girls’ Handball
Authors: Nakayama Saori , Trejo-Silva Alejandro , Gomez-Ruano Miguel Angel , Aida Hiroshi
Published: September 2024

We aimed to investigate how a ball regulation change, implemented in U15 girls’ handball games, now affects game performance and shooting plays. Over 14 matches (28 observations), we included all the attacks ( n = 813) and shooting plays ( n = 589) with the conventional ball and all the attacks ( n = 821) and shooting plays ( n = 618) with the new ball performed by both teams. We used notational analysis to compare the game performance and shooting plays in these two conditions. Our main results were as follows: (i) the attack efficacy was higher with the new ball (41.9%) than with the conventional ball (36.1%); and (ii) the prevalence of the three-line defensive system was higher with the new ball (10.5%) than with the conventional ball (2.7%). It can be inferred that the new ball enabled backcourt players to execute more powerful middle- and long-range shots, leading to their adoption of deeper defensive tactics that were effective in halting advancing backcourt players. Moreover, implementing new ball regulations resulted in a significantly higher frequency of shots targeted at the upper third of the goal frame (44.4%) compared to those observed with the conventional ball (35.8%). This implies that the introduction of the new ball enhanced precision control over shot placements, resulting in an increased player preference for targeting the upper course. Lastly, goalkeepers’ saving rates decreased under the new ball, highlighting the need for technical and tactical coaching, tailored to goalkeepers. In summary, implementing the new ball regulations had a positive impact on Japanese U15 girls’ handball performance.
Viscoelastic behavior of warp-knitted spacer fabrics in iterative compression and decompression
Authors: Alan Gonca
Published: September 2024

In this study the viscoelastic behavior of warp-knitted spacer fabrics was investigated for compressional deformation. The fabric specimens were tested via loading and unloading time intervals under predetermined conditions. Following the upside tests, specimens were relaxed for 24 h to examine the recovery prior to completing the downside tests. The data obtained from the compression and decompression cycles were examined for stress relaxation and creep through stress–time plots. From the results it was observed that, despite the non-homogeneous structure of the spacer fabric, the specimens demonstrated exponentially changing behavior within the given time intervals. Since the response of fabrics to compression and decompression cycles can be expressed as a function of time, a mathematical approach was expressed in accordance with the time-dependent behavior of the fabrics regarding the monofilaments as bent beams. The responses of the fabrics to the experimental set up conditions were evaluated to determine the potential usage performances of the fabrics. Fabric thickness, number of monofilament yarns in the structure, and thickness of the monofilaments had the major effects on the performance of the fabrics. Future research could consider modeling studies to predict usage performance, and tailoring the fabrics before production.
How the Austerity Agenda Disappeared Over a Million California Community College Students: A Faculty Perspective
Authors: Klein Debbie
Published: September 2024

The largest system of higher education in the nation, the California Community Colleges (CCC) has disappeared more than one million students in the past 15 years, a 35% decrease in its student body since 2008 despite California’s population increase. This dramatic shrinking of the CCC system was not an accident. It was manufactured by a vast neoliberal policy network and funded by edu-philanthropist foundations, with the goal of disrupting, defunding, and dismantling public education. Tracking faculty and student advocacy against so-called student success policies, this article concludes that edu-philanthropist foundations have created decades of policy designed to shrink and disinvest from California’s community colleges. Building on the literature documenting neoliberal educational reform within the public sector of the United States, this article is based on original ethnographic research and leadership experience within local and statewide faculty organizations, including participation in the CCC governance and legislative processes from 2007 to 2022. The article calls for the nation’s community colleges to build a coalition that will educate the public about the 50-plus-year neoliberal project to defund public education; expose the philanthrocapitalist takeover of community colleges; and advocate for reinvestment in the millions of students who need the community colleges the most.
Caught in the Crossfire: Anti-corporate activism and non-market strategies of corporate targets in the creation of emissions controls
Authors: Shu Ei (Emily) , Lewin Arie Y.
Published: September 2024

While a large body of research explains how social movements elicit corporate change by focusing on confrontation of activists against targeted organizations, it remains unclear how the conflicts between activists and their primary targets affect non-target firms. Drawing on social movements research and non-market strategy literature, we examine how non-target firms respond to social contentiousness in the non-market environment in the context of the creation of automotive emissions controls in Japan in the early 1970s. Our findings challenge the somewhat linear assumption that confrontation and direct action against focal firms is a necessary condition for activists seeking change. Instead, our findings underscore the importance of also considering non-target firms in understanding the impact and influences of movements on the broader non-market environment. Moreover, our findings contribute to the non-market strategy literature by revealing that social value-based strategies can serve as an alternative way for corporate targets to exert influence in non-market environments. Specifically, we present a model that shows the linkages between intentional non-market strategies and strategic motivation in market competition, thus responding to calls to consider the linkage between non-market and market strategies.
Cancel culture: Heterodox self-censorship or the curious case of the dog which didn’t bark
Authors: Norris Pippa
Published: September 2024

There is widespread concern that academic freedom is threatened by growing demands for intellectual conformity and attempted censorship from intolerant zealots. Student protests over the Israeli–Hamas conflict have intensified fierce debates about freedom of expression on campuses. This study seeks to understand the nature and scope of contemporary threats to academic freedom of expression worldwide, especially the role of self-censorship in this process. The first part unpacks the notion of a ‘cancel culture’ in academia. The research explores processes of self-censorship where scholars are unwilling to express their authentic views in public. Mechanisms theorized as potentially driving these processes include heterodox status (cultural minorities out of step with orthodox views); institutions (constitutional principles, laws, and regulations used by the authorities to govern academic speech); culture (attitudes towards free speech); and academic status (inequalities in academic power and security linked with gender and age). To examine these mechanisms, the second part sets out the research design. It draws upon survey data from the second World of Political Science survey (WPS-2023), monitoring the background and attitudes of almost 2000 political scientists living and working in around 100 countries worldwide. The third part analyzes the results, confirming the reluctance of heterodox scholars to challenge majority views. The conclusion in the fourth part summarizes the findings, considers their broader implications, and discusses the next steps in the research agenda.
A comprehensive study of recent studies on the efficiency of axial flow turbines with an investigation on blade profile modifications in stator and rotor assemblies
Authors: Sudarshan P N Vasanth , Devasenan Madhesh
Published: September 2024

Axial flow turbines are crucial in energy production and propulsion across diverse applications. As global energy needs rise, optimizing turbine efficiency is paramount. This review delves into the aerodynamic design of turbine blades, specifically examining blade profile modifications in both stator and rotor assemblies of state-of-the-art models proposed in the studies from 2019 to 2024. The focus is on mitigating performance discrepancies between idealized simulations and real-world applications, which present significant challenges such as inconsistencies in computational fluid dynamics (CFD) predictions and manufacturing constraints. Key findings from this review highlight a potential efficiency gain of 1%–3% through optimal blade designs that reduce incidence losses, secondary flows, and tip vortex formation. Advanced modeling techniques, including high-fidelity, multi-objective optimization with machine learning, are evolving to better predict and enhance turbine performance. However, gaps remain in system-level integration and the limited experimental data restricts comprehensive validation of these new designs. The insights from this review will aid the research community by identifying critical areas for future investigation, such as integrating blade aerodynamics with heat transfer and structural mechanics. Further, it emphasizes the need for exploring combinations of passive and active flow control strategies to fully harness the benefits of blade profile enhancements. These efforts are crucial for achieving substantial improvements in turbine efficiency, which are essential for meeting the growing demands for sustainable and efficient energy production.