bluuebunny/crossref_metadata_2025 huggingface dataset:
Level of Art Flow among Faculty Students of Design and Applied Arts at Taif University
Authors: Abdullah Aldhorman Ghozeail Abdulaziz
Published: September 2022

The current study sought to determine the flow level of students at Taif University’s College of Designs and Applied Arts and the disparities in average student grades based on gender, specialization, and academic level. The sample was drawn randomly from Taif University’s College of Designs and Applied Arts and included (51) male and (138) female students majoring in arts, graphic design, interior design, fashion design, and textiles. The flow scale was produced by Al-Ghamdi (2021). Overall, there is an average flow level among the sample members, with no statistically significant gender differences in flow in the first, second, and sixth dimensions, but there are disparities in flow in the third, fourth, and fifth dimensions. Aside from one group (interior design, graphic design) that favored interior design, there were no statistically significant changes in flow related to expertise. According to the data, there were no statistically significant differences in the flow due to the dimensions’ academic level variables (1st–6th). However, there were differences between the sample members in both dimensions (3rd–5th). Anxiety and tension, a lack of clarity of objectives, and dissatisfaction with the results were identified as the main reasons that impede the flow. Enrichment programs and material support were developed to boost student flow at Taif University’s College of Designs and Applied Arts.
Outcomes of Top-Down Holmium Laser Enucleation of Prostate for Recurrent/Residual Benign Prostatic Hyperplasia: One-Year Follow-Up
Authors: Zakaria Ahmed S. , Hodhod Amr , Abbas Loay , Fathy Moustafa , Abdul Hadi Ruba , Shabana Waleed , MacDonald Anastasia Alexandra , Gamaleldin Ahmed , Abdallah Mohamed , Elgharbawy Mohamed , Ahmad Abdulrahman , Roos Adam , Kotb Ahmed , Shahrour Walid , Elmansy Hazem
Published: September 2022

Introduction and Objective. We aimed to evaluate urinary functional outcomes of top-down holmium laser enucleation of the prostate (HoLEP) in patients who underwent transurethral resection of the prostate (TURP) for the management of benign prostatic hyperplasia (BPH) compared to patients with primary BPH. Materials and Methods. We carried out a retrospective analysis of patients who underwent top-down HoLEP for the management of recurrent BPH at our institution. Patients who had previously undergone TURP were assigned to group I, while those with no history of prostate surgery were allocated to group II. Preoperative clinical characteristics, enucleation time, resected tissue weight, morcellation time, energy used, and intraoperative and postoperative complications were recorded and statistically analyzed. Patients were followed up postoperatively at 1, 3, 6, and 12 months. The evaluation included the International Prostate Symptom Score (IPSS), quality of life assessment (QoL), maximum urinary flow rate (Qmax), postvoid residual urine test (PVR), and continence status. Results. Two hundred and sixty-nine patients were included in this study. Group I consisted of 68 patients with recurrent BPH, while group II included 201 patients. There were no statistically significant differences in preoperative characteristics between both groups. The median enucleation time for group I (67.5 min (25–200)) was not significantly longer than that for group II (60 min (19–165) (

p
=
0.25

)). Operative outcomes, including morcellation time, resected weight, catheter duration, and hospital stay, were comparable between both groups. At 1, 3, 6, and 12 months, all urinary functional outcomes showed significant improvement, and there were no significant differences between the two groups. At 3 months’ follow-up, two patients in group I and three patients in group II experienced stress urinary incontinence (SUI). At the last follow-up visit, one patient from group I presented with persistent SUI. Conclusions. For managing recurrent and nonrecurrent cases of BPH, top-down HoLEP is safe with comparable urinary functional outcomes. Patients with a history of previous prostate surgery can be counselled that their prior transurethral procedure does not reduce the benefits of HoLEP.
Prognostic Value of UBE2T and Its Correlation with Immune Infiltrates in Lung Adenocarcinoma
Authors: Xu Feng , Xiong Na , Yuan Yuhong , Liu Jun
Published: September 2022

Non-small cell lung cancer has a subtype with a high morbidity and mortality rate called lung adenocarcinoma (LUAD). It is critical to locate reliable prognostic biomarkers for LUAD at this time. Ubiquitin-conjugating enzyme E2T (UBE2T) has been found in numerous malignancies; however, its expression level and potential functions in LUAD are not completely understood at this time. A differentially expressed gene (DEG) screening method was used to identify genes that were expressed differently in 516 samples from LUAD and 59 samples from TCGA datasets. Clinicopathological markers were correlated with UBE2T expression. Using the Kaplan–Meier plotter database, UBE2T was evaluated for its prognostic value in the context of LUAD. In order to examine the importance of independent prognostic factors, both univariable and multivariable Cox regression models were applied. TIMER and CIBERSORT were utilized in order to investigate the connection that exists between UBE2T expression and tumor-infiltrating immune cells. This study collected 578 DEGs in total, as follows: 171 genes were significantly increased, while 408 genes were significantly decreased. We identified 9 survival-related DEGs in LUAD, including ASF1B, CA9, CCNB2, CCNE1, RRM2, SAPCD2, TCN1, TPX2, and UBE2T. Our attention focused on UBE2T, which was highly expressed in LUAD. A correlation was also found between high UBE2T expression and gender, age, advanced clinical stage, and decreased overall survival. In addition, multivariate analysis demonstrated UBE2T expression to be a significant independent diagnostic factor for patients suffering from LUAD. UBE2T was positively correlated with resting T cell CD4+ memory, myeloid dendritic cell resting, mast cell activated, macrophage M2, and B cell plasma, whereas it was negatively correlated with resting T cell CD4+ memory, MDC resting, MDC activated, macrophage M2, and B cell plasma. Overall, high expression levels of UBE2T correlated with poor overall survival in patients with LUAD, and UBE2T was an independent predictor involved in immune infiltration of LUAD. These findings offer fresh perspectives that contribute to our comprehension of the evolution of LUAD.
miR-3651 Participates in the Growth Cycle of Hepatocellular Carcinoma Cells and Promotes the Malignant Metastasis via the PI3K/AKT/mTOR Signalling Pathway
Authors: Liu Yawei , Hu Litian , Liu Qinqiang , Ye Jing , Zhang Jianping
Published: September 2022

Objective. Hepatocellular carcinoma (HCC) shows a growing incidence over the past few years, and clinical efforts are made to search for more effective novel diagnosis and therapy regimen for it to improve its outcome. This study probed into the association of miR-3651 with the PI3K/AKT/mTOR pathway to offer a more detailed reference to the follow-up exploration of novel diagnosis and therapy methods of HCC. Methods. Totally, 83 patients with HCC treated in our hospital between Apr. 2017 and Aug. 2018, 100 patients with simple liver cirrhosis (LC), and 94 normal persons over the same time span were enrolled, and serum miR-3651 in them was quantified to understand the predictive and prognostic significance of miR-3651 for HCC. In addition, with purchased human HCC cell strains (HepG2), the impacts of miR-3651 on the invasion as well as proliferation of HepG2 were determined using the MTT and Transwell assays, and the PI3K/AKT/mTOR pathway and autophagy-associated proteins in HepG2 were quantified via WT. Results. Serum miR-3651 was found to be higher in HCC patients than in LC patients and normal persons, and it presented a sensitivity and specificity of 57.14% and 94.00%, respectively, in forecasting the occurrence of HCC in LC patients. The decrease of miR-3651 in HCC patients after therapy was strongly bound up with patients’ prognosis, and its increase implied an increased risk of death. In in vitro assays, HepG2 presented higher miR-3651 expression than HL-7702, and upregulated miR-3651 intensified the invasion and proliferation of HepG2, while silencing miR-3651 gave rise to opposite results. Additionally, the PI3K/Akt/mTOR pathway in HepG2 presented an obvious activation state, and its activation was further intensified after increase of miR-3651, while its activation was suppressed after silence of miR-3651. Moreover, HepG2 presented notably downregulated autophagy-associated proteins, and the increase of miR-3651 further suppressed the autophagy process, but with the intervention of BEZ235, the impacts of miR-3651 were completely reversed. Conclusion. miR-3651 intensifies the growth and invasion of HCC cells through activating the PI3K/AKT/mTOR signalling pathway, which is probably a breakthrough in the future diagnosis and therapy of HCC.
How Does the Electronic Products Retailer Transform Operational Modes Considering Consumer Preferences for Leasing?
Authors: Tian Gaidi , Li Chunfa , Li Dongdong
Published: September 2022

Consumer interest in renting brand-new electronic products has increased recently. Some retailers started to lease them, but they remarkably depreciate shortly after leasing. If their rental income cannot bring in enough profit, should a retailer lease them? This paper uses consumer preferences for leasing to describe their rental utility. It develops an analytical framework to study how the retailer selects operational modes. In a supply chain consisting of a manufacturer and a retailer, three different operational modes are analyzed: pure selling (S), pure leasing (L), and hybrid selling-leasing (SL). Results mainly show that when consumer preferences for leasing exceed a certain threshold, both the manufacturer’s and the retailer’s profits can be increased if the retailer transforms the business operational mode from S to SL/L. When consumer preferences for leasing are within a certain range, the retailer’s profits can be increased if the operational mode is transformed from S/L to SL. This happens as both consumers’ lease and purchase requirements for electronic products are met after the transformation. The wholesale price, leasing price, selling price, and the manufacturer’s profit all rise in the SL mode as consumer preference for leasing rises, but the retailer’s profit falls. Only if the retailer cooperates with the manufacturer can the operational mode be transformed from S/L to SL when consumer preferences for leasing are lower, and the coordination contract can achieve Pareto improvement in the profits of both the manufacturer and the retailer.
circPTN Promotes the Progression of Non-Small Cell Lung Cancer through Upregulation of E2F2 by Sponging miR-432-5p
Authors: Su Jiayuan , Zhou Jinrong , Feng Yachan , Zhang Haojie , Zhang Xinyu , Zhao Xiaorong , Li Yong , Guo Xueling
Published: September 2022

Background. Non-small cell lung cancer (NSCLC) is one of the most prevalent cancers, accounting for around 80% of total lung cancer cases worldwide. Exploring the function and mechanism of circRNAs could provide insights into the diagnosis and treatment for NSCLC. Methods. In this study, we collected tumor tissues and adjacent normal tissues from NSCLC patients to detect the expression level of circPTN and analyzed the association of its expression level with the clinicopathological parameter of NSCLC patients. Moreover, the functional engagement of circPTN in NSCLC cells was examined by cell counting kit-8 (CCK-8) cell proliferation assay, transwell migration and invasion assays, and tube formation assay. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting (WB) analysis were used to detect gene and protein expression, respectively. The molecular targets of cicrPTN were predicted using starBase online resources, which was validated by RNA immunoprecipitation (RIP) and dual-luciferase reporter assay. Results. Compared with adjacent normal tissues, there was a remarkable increase of the circPTN levels in NSCLC tissues. A high level of circPTN expression was associated with more lymph node metastasis (LNM) and advanced TNM stages. Functionally, circPTN knockdown inhibited the proliferation, migration, and invasion and tube formation ability of NSCLC cells. We further demonstrated that circPTN regulated the malignant phenotype of NSCLC cells through targeting the miR-432-5p/E2F2 axis. Conclusion. Together, our results suggest that circPTN, which is upregulated in NSCLC tissues, could serve as a prognostic marker for NSCLC patients. circPTN regulates the malignant progression of NSCLC cells through targeting the miR-432-5p/E2F2 axis, which may be employed as a potential strategy for the management of NSCLC.
Registered Trials of Artificial Intelligence Conducted on Chronic Liver Disease: A Cross-Sectional Study on ClinicalTrials.gov
Authors: Zheng Gezhi , Shi Lei , Liu Jinfeng , Zhao Yingren , Du Fenjing , He Yingli , Yang Xin , Song Ning , Wen Juan , Gao Heng
Published: September 2022

Background. Artificial intelligence (AI) has been widely applied in the diagnosis and therapy of chronic liver disease (CLD), but there is currently little insight into the trials registered on ClinicalTrials.gov. Thus, this cross-sectional study was focused on analyzing the progress in the use of AI in CLD. Methods. Registered trials of AI applied in CLD on ClinicalTrials.gov were searched firstly. All available information was downloaded to Excel (Microsoft Excel, Rong, Rong, China), and duplicates were removed. We extracted the data of the included trials, then analyzed the characteristics of them finally. Results. Up to the 27th of May 2021, 6835 trials were identified following an initial search, and 20 registered trials were included after screening for inclusion and exclusion criteria. Among those trials, hepatocellular carcinoma (HCC, 40.0%) and nonalcoholic fatty liver disease (NAFLD, 20.0%) were the most widely applied CLDs for AI. Trials started in 2013 until 2021, with 17 trials (85%) registered after 2016. There was a large trend in trial enrolment, with 40% of them including samples more than 500. Five trials (25%) have been completed, but only one of these had available results. The most frequent sponsors and collaborators were both hospitals at 55%, followed by universities at 35% and institutes at 11%, respectively. Of the 20 trials included, 35% (7 trials) were interventional trials and 65% (13 trials) were observational trials. Among 7 interventional trials, most trials were for diagnosis purpose (42.86%, 3 trials); 4 trials (57.14%) were randomized; 3 trials (42.86%) applied behavioral intervention, 1 trial (14.29%) was in device intervention, 2 trials (28.57%) were in diagnostic test, and 1 trial intervention was unknown. Among 13 observational trials, 8 (61.54%) were cohort studies; 6 (46.15%) were prospective studies, 4 (30.77%) were retrospective studies, 2 (15.38%) were cross-sectional studies, and 1 (7.69%) did not involve a temporal perspective. Conclusion. The study is the first to focus on AI registration trials in CLD, which will aid relevant scholars in understanding the current state of the subject. This study demonstrates that additional research on AI used in the diagnosis and treatment of CLD is required, and timely publication of accessible results from registered trials is essential.
Research Progress of Concrete 3D Printing Technology and Its Equipment System, Material, and Molding Defect Control
Authors: Zhao Yanhua , Meng Wei , Wang Peifu , Qian Dongqing , Cheng Wei , Jia Zhongqing
Published: September 2022

The traditional construction technology not only has environmental friendly problems such as noise and dust but also has resource-saving problems such as large template quantity and low construction accuracy. In addition, the traditional construction technology has an insurmountable technical bottleneck in the construction of special-shaped buildings. Building 3D printing technology can effectively overcome many problems existing in traditional construction technology and provide unlimited possibilities for the construction of special-shaped buildings. Concrete 3D printing technology is one of the most important technical categories of building 3D printing. In this study, the research status and progress of concrete 3D technology were reviewed from the aspects of equipment system, materials, defect control, and application scenarios. On this basis, the development foreground was prospected.
An Investigation of the Electrical Properties of Pressboard Impregnated with Mineral Oil-Based Nanofluids at Different Concentrations of Fe3O4 Magnetic Nanoparticles
Authors: Muangpratoom Pichai , Khonchaiyaphum Issaraporn , Vittayakorn Wanwilai
Published: September 2022

The purpose of this study was to investigate the electrical properties of pressboard impregnated with mineral oil-based nanomaterial. The nanomaterial focused on in this study was magnetite (Fe3O4) at ratios of 0.01%, 0.03%, and 0.05% by mineral oil volume. The electrical tests were performed on the AC breakdown strengths and positive-negative lightning impulse breakdown strengths on impregnated pressboard were carried out in compliance with IEC 60641 and IEC 60243, respectively. Scanning electron microscopy (SEM) and X-ray Diffraction (X-RD) were used to study the micro surface and show that Fe3O4 nanoparticles of nanoscale size were adhered to the pressboard surface and exist in an amorphous state. The results found that the AC breakdown strengths of pressboard impregnated with mineral oil-based Fe3O4 nanofluids at 0.03 wt% were increased the most. Moreover, the lightning impulse breakdown strengths of pressboard impregnated with mineral oil-based Fe3O4 nanofluids at 0.03 wt% were increased the most in both positive and negative polarities. The results, thus, showed promising directions for applications of Fe3O4 nanomaterials to improve the electrical properties of pressboard.
The Clinical and Genetic Characteristics in Children with Idiopathic Hypogonadotropin Hypogonadism
Authors: Zhou Qiong , Sheng Wenbin , Yang Suhong , Zou Chaochun
Published: September 2022

Background. Idiopathic hypogonadotropin hypogonadism (IHH) is caused by hypothalamic-pituitary-gonadal axis dysfunction. This is divided into Kallmann syndrome which has an impaired sense of smell and hypogonadotropin hypogonadism with normal olfactory (nIHH sense. Approximately 60% of patients are associated with Kallmann syndrome, whereas there are approximately 40% with hypogonadotropin hypogonadism (nIHH). This disease is associated with various variants in genes along with different phenotypic characteristics, and even those gene variations could also lead to the cancer formation in patients. So, current study has been designed to investigate and to better understand the characteristics of various IHH-associated genes and the correlation between IHH genes and phenotype. Methods. The cohort included 14 children with IHH (6 patients of KS and 8 patients of IHH), including 13 boys and 1 girl. Exclusion criteria are as follows: diagnosis of secondary hypogonadotropin hypogonadism due to tumor, trauma, drugs, or other systemic diseases. Clinical data and genetic results were analyzed. Results. Almost all male patients showed micropenis (12/13, 92.3%), and few of them had cryptorchidism (5/13, 41.7%). A total of 6 genes, CHD7, PROKR2, ANOS1, FGFR1, SEMA3A, and NDNF, were detected. CHD7 was the most common (11/17, 64.7%), and the main mutation type was missense mutation (14/16, 87.5%). Six reported variants and 10 new variants (5 genes, including entire ANSO1 duplicates) were found. Neonatal variation was detected in 3 patients with IHH. Eight patients inherited the variation from their father, while five patients inherited it from their mother. One patient had both FGFR1 and SEMA3A gene variants, while the other had two different CHD7 gene variants and entire ANSO1 repeats. According to ACMG criteria, 4 variants were pathogenic (P), 2 were possibly pathogenic (LP), and 8 had uncertain significance (US). In patients with P or LP (5/6, 83.3%), we found that extragonadal symptoms were more common. Conclusions. It was concluded that variations in the studied genes could lead to the IHH. Ten new variants have been reported which may lead to different symptoms of IHH. For CHD7 variants, the rare sequencing variants (RSVs) of P or LP showed commonly associated with CHARGE syndrome. Findings of the current study may help for the better diagnosis and treatment of IHH.
Metabolic Syndrome and Its Associated Factors among Type 2 Diabetic Patients in Southwest Ethiopia, 2021/2022
Authors: Gemeda Dereje , Abebe Endegena , Duguma Abdissa
Published: September 2022

Background. Metabolic syndrome is one of the leading global public health and clinical challenges, with increasing prevalence figures ranging from 10% to as high as 84%. There is a 5-fold increase in metabolic syndrome associated with type 2 diabetes and a 2-fold increase associated with the development of cardiovascular disease. The calorie-dense diet and sedentary life patterns are the most important contributory factors that have been established. Objective. This study is aimed at assessing metabolic syndrome and its associated factors among patients with type 2 diabetes attending chronic follow-up units at hospitals in Southwest Ethiopia, in 2020. Methods. This study was conducted at hospitals in Southwest Ethiopia, using an institutional-based cross-sectional study design from September 1, 2020, to August 30, 2021. Data was collected from 422 type 2 diabetics through face-to-face interviews using structured and pretested questionnaires. Data were entered into Epi-data version 4.4.1 and exported for analysis to the Statistical Package for Social Sciences 25. The magnitude of metabolic syndrome was determined by using the National Cholesterol Education Program Third Adult Treatment Panel III criteria. Bivariate and multivariable logistic regression analyses were used to evaluate associated factors for the outcome variable. A

P

value of less than 0.05 was considered statistically significant. Result and Conclusion. Out of the 422 sample sizes, 394 type 2 diabetics participated in this study, giving a response rate of 93.36%. The overall prevalence of metabolic syndrome among type 2 diabetics in this study was 68.3%, using the National Cholesterol Education Program and Third Adult Treatment Panel criteria. The associated factors for metabolic syndrome among type 2 diabetics are urban residency, old age, physical inactivity, salt intake, inadequate fruit and vegetable consumption, palm oil, and eating meat.
Adaptive Fuzzy Controller Design for Uncertain Robotic Manipulators Subject to Nonlinear Dead Zone Inputs
Authors: Zhang Hua
Published: September 2022

This paper comes up with the adaptive fuzzy scheme for multi-degree robotic manipulators with dead zone. Fuzzy logic system is employed to approximate unknown nonlinear functions and input nonlinear functions with dead zones that are introduced. The adaptive fuzzy technique is utilized to deal with the problems of multi-joint robotic manipulators with unknown nonlinear functions in dead zones. Based on Lyapunov criterion, all the states and signals involved in the system are maintained in a certain bounded region and the tracking error converges to a small domain of origin. Finally, a simulation example of robotic manipulators with two joints is structured to confirm the practicability of the raised scheme.
TLR-8, TNF-α, and ESR-1α Gene Polymorphism Susceptibility in Onset of Arthritis
Authors: Mukhtar Maryam , Sheikh Nadeem , Batool Andleeb , Saleem Tayyaba , Khawar Muhammad Babar , Irfan Mavra , Suqaina Saira Kainat
Published: September 2022

Arthritis is a genetic disorder characterized by bones and joint degradation assisted by severe pain and inflammation. It is evident by the studies that 0 candidate genes variations play vital role in its development and progression. Therefore, we investigated the genetic variation of TLR-8, TNF, and ESR-1α genes in the Pakistani population. A case-control study comprising 300 RA, 316 OA, and 412 control subjects was conducted. PCR-RFLP and direct sequencing methods were used for determining genetic variations. Analysis was performed by using PLINK and MEGA 6.0 software. Allelic and genetic frequencies of polymorphisms identified on rs3764879 (TLR-8), rs3764880 (TLR-8), rs5744080 (TLR-8), rs1800629 (TNF), rs2228480 (ESR-1α), and rs1451501590 (ESR-1α) were significantly varied among RA, OA, and controls. Novel functional mutations SCV000844945 and SCV000844946 on TLR-8 as well as a non-functional SCV000804801 and functional variation SCV000804802 on ESR-1α were also identified and reported for the first time in the studied population. Multiple site analyses indicated that polymorphisms on TLR-8 and ESR-1α genes were significant risk factors in disease onset to the next generation. In conclusion, TLR-08 and ESR-1α were significant in the onset of arthritis whereas the TNF was not found as a significant risk factor in the onset of RA and OA.
Erythropoietin Activates Autophagy to Regulate Apoptosis and Angiogenesis of Periodontal Ligament Stem Cells via the Akt/ERK1/2/BAD Signaling Pathway under Inflammatory Microenvironment
Authors: Huang Denghao , Lei Jie , Li Xingrui , Jiang Zhonghao , Luo Maoxuan , Xiao Yao
Published: September 2022

Background. Angiogenic tissue engineering is a vital problem waiting to be settled for periodontal regeneration. Erythropoietin, a multieffect cytokine, has been reported as a protective factor for cell fate. According to our previous study, erythropoietin has a significantly angiogenic effect on periodontal ligament stem cells. To further explore its potential effects and mechanism, we studied biological behaviors of periodontal ligament stem cells under inflammatory microenvironment induced by different concentrations (0, 10, 20, 50, and 100 ng/mL) of tumor necrosis factor-α (TNF-α) and examined how different concentrations (0, 5, 10, 20, and 50 IU/mL) of erythropoietin changed biological behaviors of periodontal ligament stem cells. Materials and Methods. Cell Counting Kit-8 was used for cell proliferation assay. Annexin V-PI-FITC was used for cell apoptosis through flow cytometry. Matrigel plug was adopted to measure the angiogenic capacity in vitro. RNA sequencing was used to detect the downstream signaling pathway. Quantitative real-time polymerase chain reaction was conducted to examine mRNA expression level. Western blot and immunofluorescence were applied to testify the protein expression level. Results. Periodontal ligament stem cells upregulated apoptosis and suppressed autophagy and angiogenesis under inflammatory microenvironment. Erythropoietin could activate autophagy to rescue apoptosis and angiogenesis levels of periodontal ligament stem cells through the Akt/Erk1/2/BAD signaling pathway under inflammatory microenvironment. Conclusions. Erythropoietin could protect periodontal ligament stem cells from inflammatory microenvironment, which provided a novel theory for periodontal regeneration.
Dosimetric Evaluation of the Uterus in Patients Receiving Total Body Irradiation with Ovarian Shielding
Authors: Akahane Keiko , Kako Shinichi , Suzuki Masato , Takahashi Yuta , Hatanaka Shogo , Kawahara Masahiro , Nakada Yukari , Ogawa Kazunari , Takahashi Satoru , Fukuda Yukiko , Endo Masashi , Oyama-Manabe Noriko , Kanda Yoshinobu , Shirai Katsuyuki
Published: September 2022

Infertility is a well-known late complication in patients receiving hematopoietic stem cell transplantation (HSCT). We previously reported that total body irradiation (TBI) with ovarian shielding reduces the radiation dose to the ovaries to 2.4 Gy – one-fifth of the dose compared to conventional TBI – and preserves fertility without increasing the risk of relapse. Exposure to the uterus and ovaries can reportedly affect pregnancy and childbirth. However, the dose constraint of the uterus that causes infertility remains unknown. Herein, we report the pregnancy and birth outcomes of 2 patients who gave birth following TBI with ovarian shielding and evaluated the dose to the uterus using a dose-volume histogram. Case 1 involved a 30-year-old woman with acute myeloid leukemia who underwent HSCT at 21 years of age with a uterus mean dose (Dmean) of 7.0 Gy. She had a natural pregnancy and elective cesarean section at 38 weeks of gestation due to hypertensive disorders of pregnancy. She gave birth to a normal-birthweight infant. Case 2 involved a 32-year-old woman with T-cell acute lymphoblastic leukemia who underwent HSCT at 30 years of age with a uterus Dmean of 7.6 Gy. Her baby was delivered at full term with normal birthweight. These results indicate that a uterus Dmean between 7.0 and 7.6 Gy does not have a significant impact on pregnancy and delivery with the ovarian function being preserved for patients who received TBI with ovarian shielding after puberty.
Prenatal Ultrasound Diagnosis of Persistent Hyperplastic Primary Vitreous with Retinoblastoma
Authors: Li Tian-gang , Cao Hai-bo , Gao Xiu-yun , She Xiao-ning , Xu Sheng-fang , Zhang Yu , Zhang Dengcai
Published: September 2022

Introduction: Persistent hyperplastic primary vitreous (PHPV) involves a spectrum of congenital ocular abnormalities characterized by the presence of a vascular membrane behind the lens. Retinoblastoma is a life-threatening intraocular malignancy that can cause blindness, eye loss, or even death. PHPV and retinoblastoma are extremely rare prenatal diseases. Case Presentation: Here, we present a case of fetal PHPV with retinoblastoma diagnosed using prenatal ultrasound. The unilateral lenses were hyperechoic, and irregular echogenic bands between the lenses and posterior eye walls were observed. In cases where the blood flow signal continues in the band-shaped hyperechoic area, PHPV with retinoblastoma should be suspected. Conclusion: PHPV with retinoblastoma can be prenatally diagnosed.
PADRE ANTÔNIO VIEIRA E AS INFLUÊNCIAS DO MESSIANISMO JUDAICO NO SEBASTIANISMO PORTUGUES DO SÉC. XVII
Authors: Andrade Lucas Silveira
Published: September 2022

Este artigo busca analisar a presença do messianismo judaico no discurso sebastianista do Padre jesuíta Antônio Viera (1608-1697) em seu contexto político e religioso. Para isso, partirei do exame do contato entre Vieira e os judeus expulsos da Espanha e de Portugal no final do século XV, na região de Flandres, nos Países Baixos. Tratarei também da relação de proximidade entre Vieira e o rabino Menasseh Ben Israel (1604-1657), em uma de suas viagens diplomáticas em favor da enfraquecida coroa portuguesa. O discurso do jesuíta se constrói em rigoroso processo que envolve os aspectos políticos de Portugal, assim como uma religiosidade na qual estavam envolvidos estes mesmos aspectos. Havendo passado longo tempo junto aos judeus, o jesuíta não deixou de levantar outras questões como o retorno destes às terras portuguesas, o que Viera via como uma oportunidade para auxiliar economicamente o Reino, como também visava à reunião das tribos perdidas de Israel em território português. PALAVRAS CHAVE: Padre Antônio Viera, messianismo, sebastianismo, Portugal, Judaísmo.
O YISHUV E O HOLOCAUSTO: A RELAÇÃO ENTRE O PROTO-ESTADO JUDEU E O EXTERMÍNIO DOS JUDEUS NA DIÁSPORA
Authors: Andre Thaily Viviane
Published: September 2022

Um dos temas mais polêmicos da história do Estado de Israel até hoje é sobre o quanto os líderes do Yishuv, o proto-Estado judeu na Palestina sob Mandato Britânico, sabiam sobre a magnitude da destruição da comunidade judaica na Europa, perpetrada pela Alemanha nazista, e o quanto fizeram para salvar esses judeus. O presente artigo tem por objetivo tentar responder tais questões complexas, além de apresentar o debate historiográfico dos principais autores que se aprofundaram sobre a temática.
NOTAS SEMIÓTICAS SOBRE O APÓLOGO DE JOTÃO (JUÍZES 9.8-15)
Authors: Proença Paulo Sérgio de
Published: September 2022

A Bíblia apresenta rica diversidade de gêneros e temas literários. Este trabalho vai se ocupar de um: trata-se do apólogo de Jotão, que tematiza o poder, no que diz respeito a sua instituição e exercício. Para atividade analítica serão seguidos os princípios da semiótica greimasiana. Resultados apontam para a tensão própria de disputa pelo poder, em que uma tradição antimonárquica defende seus pontos de vista, dos quais o apólogo de Jotão é um exemplo
A TEMPORALIDADE E O DESENVOLVIMENTO DA ESCRITA HEBRAICA E DOS TEXTOS BÍBLICOS NO MUNDO ANTIGO: APONTAMENTOS
Authors: Ripoli Fernando
Published: September 2022

Este ensaio tem como objetivo apresentar a algumas informações de como o historiador entende a história e o tempo, a construção da escrita do hebraico no mundo antigo, e de quando os textos bíblicos começam a ser escritos pelos israelitas. Para isto, faremos uma pequena introdução do nascimento da escrita na história e do surgimento do hebraico na história israelita, para após, descrevermos em que período o hebraico bíblico nasce na história humana, obviamente que a construção do hebraico bíblico, está relacionada com a lista das línguas semíticas. Para tal tarefa precisaremos entender como nasce à escrita na história antiga, para após, entrarmos nos questionamentos do hebraico como escrita dos textos da bíblia hebraica, entre os israelitas.Palavras-chave: Escrita, Hebraico bíblico, textos e contextos históricos.[1] BLOCH, Marc. Apologia da História ou o ofício de historiador. Rio de Janeiro: Jorge Zahar, 2001.
JUDEU: ALMA SENSÍVEL E REVELAÇÃO, EM FARDA, FARDÃO, CAMISOLA DE DORMIR, DE JORGE AMADO
Authors: Muraca Márcio Henrique
Published: September 2022

O judeu aparece na obra de Jorge Amado, assim como na de outros autores de esquerda da geração de 1930, como metonímia de subversão, assim como de “comunismo”, especialmente sob a vertente stalinista do período. Sobre tal aspecto, já se escreveu sobre a presença do judeu em tais obras. No entanto, além dessas conclusões, é possível entrever numa obra tardia de Jorge Amado, como Farda, fardão, camisola de dormir (1979), algo mais: a do judeu não apenas como profeta do socialismo, mas também como elemento que se vincula à sensibilidade e à revelação de um tempo/espaço mítico, poético, utópico.
A Proibição da Representação da Imagem Humana na Iconografia do Povo de Israel Durante o Período Bíblico
Authors: Oliveira Karina Santos de
Published: September 2022

Este artigo apresenta uma pesquisa de mestrado sobre as implicações da proibição bíblica de confeccionar imagens na inibição da representação da imagem humana na iconografia do povo de Israel durante o período bíblico. Era evitado confeccionar imagens humanas em qualquer situação, pois havia um temor de que o povo de Israel se corrompesse e adorasse outros deuses, adotando superstições e o sincretismo religioso. Mais tarde, passaram a ser feitas imagens humanas que não tivessem função de objetos de culto.
A Utopia Pós-Sionista de Amós Oz
Authors: Vaidergorn Ricardo
Published: September 2022

Este ensaio aborda o romance A caixa preta de Amós Oz. Observa o confronto de dois  personagens opostos; o ex-marido e o atual.  O anterior é um bem nascido da elite engajada na modernidade. O novo é um excluído que vive à margem das certezas e ideias nacionais ou institucionais, um desengajado e quer ser reconhecido. Espelha a descentralização do sujeito em oposição ao institucionalizado. Ao mesmo tempo, sociólogos e historiadores de então, nos anos 1970, ironizavam a nova tendência da pós-modernidade como mais uma mera utopia. Em Israel o conflito espelhado em A caixa preta, atualmente reconhecido com o impacto dos primórdios da globalização sobre as ideologias nacionais, na época foi traduzido como “Utopia Pós-Sionista”.
O Mashal rabínico (parábola rabínica): comparação ou metáfora?
Authors: Peuzé Pascal Jean André Roger
Published: September 2022

O mashal rabínico (parábola rabínica) foi considerado durante séculos como uma simples comparação destinada a ilustrar os ensinamentos dos Sábios de Israel. Porém, nas últimas décadas, os estudos sobre a linguagem revolucionaram a abordagem deste gênero literário e afinaram a nossa compreensão sobre a sua natureza e função. Longe de ser meramente uma comparação, ele apresenta-se como uma metáfora desenvolvida – metáfora viva – com um alto potencial hermenêutico. É por esta razão que os Sábios multiplicaram o uso das parábolas a fim de perscrutarem a Torá. Este artigo, tomando por base um exemplo extraído da Mishná (Mishná Sukká 2,9), pretende mostrar a especificidade do mashal rabínico.
A Escrita de Sayed Kashua
Authors: Schlesinger Juliana Portenoy
Published: September 2022

O idioma tem um papel central em apontar em que contexto social, político e/ou econômico uma pessoa situa-se e quais as conseqüências que o uso desta língua causa naqueles que a ouvem ou a lêem. A língua hebraica, tratada particularmente neste trabalho de doutorado, adquire relevância significativa dentro do contexto do estabelecimento do Estado de Israel e do atual conflito israelense-palestino. Sayed Kashua é um jovem jornalista e escritor que nasceu na cidade árabe de Tira, em Israel, e que escreve sua obra em hebraico. Ele tem dois romances publicados e escreve semanalmente crônicas jornalísticas no jornal israelense Haaretz. Daqueles que são de origem islâmica, como é o caso de Kashua, é esperado que falem e escrevam primeiramente na língua árabe, levando-se em conta que o sistema educacional israelense é organizado por língua de instrução, isto é, judeus são lecionados nas diversas disciplinas do ensino fundamental na língua hebraica enquanto que aqueles de origem árabe são direcionados, durante este período, ao ensino na língua árabe. Contudo, Kashua é uma exceção por ter estudado numa escola destinada a alunos especiais, sem distinção entre etnias ou religião, cujo ensino é feito em hebraico.
Estudos Judaicos: entre o método e a metafísica
Authors: Carvalho Francisco Moreno
Published: September 2022

Os estudos judaicos estão presentes na Universidade desde o Renascimento, com a criação de cadeiras de língua hebraica em diversas universidades europeias. Mais tarde surgiram os estudos bíblicos e de literatura rabínica, seguidos pelos de história e pensamento judaico. O interesse específico de investigadores em determinados campos gerou novos ramos de estudo, como o da mística judaica.
O Mensageiro no Contexto da Bíblia Hebraica
Authors: Junior Irrael Baboni Cordeiro de Melo
Published: September 2022

O objetivo deste ensaio é analisar os mensageiros humanos (mal’akh) – os responsáveis pela comunicação e diplomacia - no contexto literário bíblico, procurando identificar suas funções, características e peculiaridades, fazendo também uso da comparação com registros de seus correspondentes nas culturas circundantes do antigo Israel.
Narrativas Mitológicas e Tradições Judaicas: O Mito do Judeu Errante na Poesia de Vinicius de Moraes
Authors: Pereira Kenia Almeida
Published: September 2022

Há poucos estudos sobre a primeira fase metafísica do autor Vinicius de Moraes. Percebe-se, no entanto, que, neste período, o poeta se debruçou sobre alguns elementos mítico-simbólicos relacionados às tradições judaico-cristãs, ainda pouco estudadas e conhecidas no meio acadêmico. Diante destas considerações, este artigo tem como principal objetivo comentar o poema Judeu Errante, do poeta Vinicius de Moraes, presente em seu primeiro livro, intitulado O caminho para a distância, publicado em 1933.
A Língua Hebraica e o nacionalismo Judaico
Authors: Kotler Carmia
Published: September 2022

A definição da nossa identidade muitas vezes é percebida pela forma que o outro nos vê. Em 1922 Winston Churchill relatou todas as conquistas da sociedade judaica em Eretz Israel nas últimas três gerações. Entre essas contou que todos os seus assuntos são tratados em hebraico, que é a língua falada, e jornais em hebraico servem as necessidades da sociedade. Esse relato poderia existir graças aos pioneiros que chegaram em Eretz Israel nas primeiras ondas de imigração, e assumiram para si a importância da renovação da oralidade em hebraico. Com essa escolha consciente, garantiram o renascimento da língua hebraica como parte muito importante da renovação da nacionalidade judaica.
Imaging Considerations and Clinical Implications of Mitral Annular Disjunction
Authors: Drescher Caitlin S. , Kelsey Michelle D. , Yankey George S. , Sun Albert Y. , Wang Andrew , Sadeghpour Anita , Glower Donald D. , Vemulapalli Sreekanth , Kelsey Anita M.
Published: September 2022

Mitral annular disjunction is increasingly recognized as an important anatomic feature of mitral valve disease. The presence of mitral annular disjunction, defined as separation between the left atrial wall at the point of mitral valve insertion and the left ventricular free wall, has been associated with increased degeneration of the mitral valve and increased incidence of sudden cardiac death. The clinical importance of this entity necessitates standard reporting on cardiovascular imaging reports if patients are to receive adequate risk stratification and management. We provide a narrative review of the literature pertaining to mitral annular disjunction, its clinical implications, and areas needing further research.
Impact of Serial Coronary Stenoses on Various Coronary Physiologic Indices
Authors: Ahn Jung-Min , Nakayoshi Takaharu , Hashikata Takehiro , Kashiyama Kuninobu , Arashi Hiroyuki , Kweon Jihoon , van’t Veer Marcel , Lyons Jennifer , Fearon William F.
Published: September 2022

Background:

Determining the functional significance of each individual coronary lesion in patients with serial coronary stenoses is challenging. It has been proposed that nonhyperemic pressure ratios, such as the instantaneous wave free ratio (iFR) and the ratio of resting distal to proximal coronary pressure (Pd/Pa) are more accurate than fractional flow reserve (FFR) because autoregulation should maintain stable resting coronary flow and avoid hemodynamic interdependence (cross-talk) that occurs during hyperemia. This study aimed to measure the degree of hemodynamic interdependence of iFR, resting Pd/Pa, and FFR in a porcine model of serial coronary stenosis.

Methods:

In 6 anesthetized female swine, 381 serial coronary stenoses were created in the left anterior descending artery using 2 balloon catheters. The degree of hemodynamic interdependence was calculated by measuring the absolute changes in iFR, resting Pd/Pa, and FFR across the fixed stenosis as the severity of the other stenosis varied.

Results:

The hemodynamic interdependence of iFR, resting Pd/Pa, and FFR was 0.039±0.048, 0.021±0.026, and 0.034±0.034, respectively (all
P
<0.001). When the functional significance of serial stenoses was less severe (0.70–0.90 for each index), the hemodynamic interdependence was 0.009±0.020, 0.007±0.013, and 0.017±0.022 for iFR, resting Pd/Pa, and FFR, respectively (all
P
<0.001). However, in more severe serial coronary stenoses (<0.60 for each index), hemodynamic interdependence was 0.060±0.050, 0.037±0.030, and 0.051±0.037 for iFR, resting Pd/Pa, and FFR, respectively (all
P
<0.001).

Conclusions:

When assessing serial coronary stenoses, nonhyperemic pressure ratios are affected by hemodynamic interdependence. When the functional significance of serial coronary stenoses is severe, the effect is similar to that which is seen with FFR.
A Greek-Coptic Miaphysite Litany from Thebes (P.Mon.Epiph. 49)
Authors: de Bruyn Theodore
Published: September 2022

A bilingual Greek-Coptic manuscript (P.Mon.Epiph. 49+592) found at the monastic settlement of Epiphanius in Western Thebes contains a litany recounting the principal events in the saving work of Christ. The litany has been overlooked in scholarship on the manuscript and on comparable litanies from antiquity. It differs from other litanies in attributing all the statements to God rather than to Christ. The article argues that the litany was an expression of miaphysite affiliation and belief. The article contextualizes the litany in the robust miaphysite culture of Thebes in the early seventh century and in the Greek-Coptic bilingualism of the time, and it discusses possible uses of the litany in collective worship, monastic prayer, and other rituals.
L’être et le temps dans le Parménide et dans le Timée de Platon
Authors: Karfík F.
Published: September 2022

Two of Plato’s dialogues, the Parmenides and the Timaeus, deal explicitly with the relationship between being and time. The former builds on the assumption that whatever is must be temporal, while the latter makes being and time mutually exclusive. This paper begins by examining how the argument develops in the Parmenides, specifically in the corresponding sections 140e1-142a1 and 151e3-155e3 of the first and the second deductions of the dialectical exercise, as well as in the corollary to the second deduction at 155e4-157b5. It then compares this argument with the account of time given in Timaeus 37e6-39e2, which alludes to the account given in the Parmenides. In stressing the incompatibility of these two accounts, it highlights a remarkable feature they both share. Parmenides’ argument starts from the assumption that whatever is in time must be present, past or future, whether a process or a state resulting from a process. As he advances further in the game of Zenonian antilogies, however, he reduces the dimension of the present to a mere ‘now’, conceived of as a ‘stop’ in the process of becoming. In the corollary, he eventually removes the present from time the ‘instant’ in which a change between two mutually exclusive processes or states occurs. Timaeus, for his part, immediately rules out that the present is a temporal dimension, by restricting temporality to the past and the future. Thus, in both accounts, the present vanishes from time and temporal processes are made dependent on extratemporal conditions. However, Parmenides’ argument points to an extratemporal principle of indeterminacy allowing for change, while, for Timaeus, there are two extratemporal conditions for temporal processes, namely the being of the intelligible Forms, on the one hand, and a pre-cosmic, disorderly becoming in space, on the other.
Resisting to the Beat: Exploring the Theological and Educational Significance of Hip Hop as an Act of Resistance
Authors: Cloete Anita
Published: September 2022

The article wishes to explore the theological significance of Hip Hop as an everyday practice of resistance that warrants practical-theological reflection. The first section provides a short background of how Hip Hop came into existence and highlights its core elements, like the role of memory, resistance, social analysis, and critique in a local and global context. This is followed by an explanation of the practical-theological focus of the article. The second section offers a detailed discussion of the religious and theological value of Hip Hop, while the final section focuses on how this act of resistance provides a platform that could shape agency, especially among youth, and dissects the educational value of Hip Hop as cultural text. Considering the context and content of Hip hop, it is argued that it could be instrumental in being a voice for the voiceless and marginalised as an essential aspect of popular culture in contexts like South Africa and Brazil.
Italian Prisoners Who Died During and After the First World War: A Quantitative Assessment
Authors: Fornasin Alessio , Freni Giuliana
Published: September 2022

The number of Italian military prisoners who died in enemy hands stands, according to the Italian historiography on the First World War, at 100,000 or more. In this paper, we offer an alternative estimate of the number of deaths using both individual and aggregate data. The reconstruction distinguishes between soldiers who died in captivity and soldiers who died as a consequence of captivity during and after the war. The results demonstrate that the number 100,000 is too high. The correct number would be, for the period from 25 May 1915 to 31 December 1925, above 57,000 and probably lower than 73,000.