bluuebunny/crossref_metadata_2025 huggingface dataset:
THEORETICAL ASPECTS OF SAFETY IN TOURISM IN UKRAINE
Authors:   Zaporizhzhia National University, Kryvolapov Eduard
Published: February 2022

The purpose of this work is to reveal the theoretical aspects of tourism security in Ukraine, as well as to provide a generalized description of the components of the security system of the tourism sector of Ukraine. Method. The study used general scientific methods, including analysis, scientific synthesis, analytical method, methods of comparison and generalization. The influence of the components of the security system of the tourism sector of Ukraine on the state and development of the tourism business in Ukraine is considered. The most important features of tourism safety in Ukraine are identified. An analysis of research on the impact of tourism on the world economy and conclusions on this issue. Ukraine is characterized in terms of tourist attractiveness in the world and the problem of this area at the international and regional levels is revealed. The scientists who have devoted their scientific works and research to the problem of formation, functioning and management of the tourist industry, namely: S.N. Dombrovska, NV Василиха, Д.І. Burak, A.V. Bakurova, M.Yu. Barna, S.W. Master and others, as well as the problem of safety and risks in the tourism sector: MB Биржаков, Ю.Ф. Волков, М.П. Denisenko, NI Garanin, NP Казаков, В.М. Kozynets, NV Korzh, O.M. Kornienko, EL Pisarevsky, LL Rudenko and others. The scientific novelty lies in the fact that based on the existing approaches in the scientific literature to the definition of economic security, the components of the security system of the tourism business of Ukraine have been identified. Examples of the development of tourism and security in this area, both at the international and regional levels, are given. The main tasks of state regulation of security of the national tourist market of Ukraine are determined. Accordingly, the international approach to security issues in the field of tourism is described on the example of the General Military Council. Based on the Strategy for the development of tourism and resorts for the period up to 2026, an algorithm for building a system of economic security of a tourist enterprise has been developed. Practical meaning. The results of this study are the basis for the study of the basics of ensuring safe and comfortable recreation of people in their spare time both in Ukraine and internationally. A list of measures to ensure the security of tourism in Ukraine as a whole is proposed.
PROBLEMS OF TOURISM AND HOSPITALITY DEVELOPMENT IN THE CONDITIONS OF THE COVID 19 PANDEMIC: WORLD AND UKRAINIAN TRENDS
Authors:   Taras Shevchenko national University of Kyiv, Lyubitseva Olha , Smyrnov Igor ,   Taras Shevchenko national University of Kyiv
Published: February 2022

The aim of the article is to reveal the changes and problems that have arisen in the field of tourism and hospitality in the world and in Ukraine as a result of the impact of the Covid-19 pandemic and ways to solve these problems. Research methodology. That's author's analysis of materials of the current World and Ukrainian press, which reflected the actual state of the problem and new phenomena in the field of tourism and hospitality of the world and Ukraine. The article is based on the results of research and reflections of the authors on the impact of the pandemic on tourism and hospitality fields, taking into account world and Ukrainian experience [1], as well as on the author's analysis of current Ukrainian press publications on current changes in 2020-2021 in in the field of tourism and hospitality in the world and in Ukraine during the implementation of measures to combat the destructive effects of the pandemic on travel industry [2-10]. Results of the research. Problems, changes, new phenomena in the field of tourism and hospitality of the world and Ukraine during the pandemic and quarantine restrictions in travel in the field of domestic and international tourism were identified. The Covid-19 pandemic, which suddenly "fell" on world tourism in 2020-2021, not only slowed down its development, including in Ukraine, but also caused significant changes in the entire field of tourism and hospitality. The essence of these changes is revealed, which included not only "minuses", but also certain "pluses". Practical significance. Is to identify problems of tourism and hospitality during the Covid-19 pandemic in 2020-2021 in Ukraine and the world and ways out of the crisis of the travel industry, taking into account the experience of other countries and features of solving the above problems in tourism, hotel and restaurant industry in Ukraine. Thus, the introduction and disclosure of the essence of new phenomena in world tourism and hospitality (travel shaming, workcation, work from hotel, staycation, digital nomads, travel bubbles) led to their use in the practice of tourism in Ukraine, for example, in hotels of Lviv.
TERRITORIAL ORGANIZATION OF MUSEUMS AS OBJECTS OF ETHNOCULTURAL POTENTIAL OF CHERNIVTSI OBLAST
Authors:   Yuriy Fedkovych Chernivtsi National University, Kostaschuk Ivan , Kisil Roman ,   Yuriy Fedkovych Chernivtsi National University
Published: February 2022

Goal of the article: Conduct research on the territorial organization of museums of different levels and types in the communities of Chernivtsi oblast as important objects of ethnocultural potential of the region. Identify the distribution of museums by different classification criteria and trace their importance for the development of certain types of tourism. Research methodology. To obtain information, various sources of information were first studied, namely: literary, official Internet portals of communities and districts of Chernivtsi Oblast State Administration and Chernivtsi Oblast Council. At the next stage, a fairly detailed database was formed, which reflects the types of museums according to all the classification features presented in the work, as well as their ethnicity. This allowed to establish the contribution of each ethnic group in the formation of ethnocultural potential of the region, which allows us to talk about cooperation with neighboring countries in the framework of ethnocultural interaction. Results of the research. Chernivtsi oblast is a striking example of ethnocontact and polyethnic region, in which Ukrainians, Romanians, Moldovans, Jews, Russians, Poles, Armenians and other ethnic groups created and continue to create their cultural heritage. Ukrainians in the region own 152 museums, Romanians – 12, Moldovans – 14, Russians – 1. Also, separate exhibitions are dedicated to the Jewish, Polish, German, Armenian and other ethnic groups. Of course, such differences in the ethnicity of museums, as an important component of ethnocultural development of the region, are of great practical and scientific importance. The scientific novelty lies in the development of a detailed classification of museums and their typology, as well as in identifying the place of museums in the ethnocultural development of the polyethnic region. These studies should be conducted in other regions of our country. The practical significance of the obtained results lies in the possibility of finding investments to increase the tourist attractiveness of both individual administrative units and the region as a whole. Museums also play an important role in shaping the ethnic, historical, ethnocultural, national-patriotic and other perceptions of the territory and identity of their people.
Paleontological and biostratigraphical characteristics of the Badenian deposits on the Srebrenik-Donja Orahovica profile (Bosnia and Herzegovina)
Authors: Ferhatbegović Zijad , Avdić Amila , Durmić Sumeja
Published: February 2022

The paper describes the biostratigraphic and paleontological research conducted on the geological section of Srebrenik-Donja Orahovica (Northern Bosnia and Herzegovina). The samples for micropaleontological research were taken from the exploration works (eight wells and nine excavations). Based on the presence of microforaminifera, the stratigraphic level of Lower Badenian was defined. According to micropaleontological and biostratigraphic analyzes within this stratigraphic level, one local foraminiferal zone was identified: zone with Trilobatus trilobus and Orbulina suturalis which represents the upper parts of the Lower Badenian. This zone is characterized by a rich microfossil community with a dominance of planktonic forms over benthic ones, normal salinity, warm sea, and basic character of the environment.
Modern vision of pathogene­sis, clinical and immunological features and new methods of atopic dermatitis treatment
Authors: Makeev Oleg G , Antonova Svetlana B , Ufimtseva Marina A , Efimova Maria S , Mylnikova Ekaterina S , Korotkov Artem V , Shuman Evgenij A , Sichkar Dar'ya A , Desyatova Mariya A
Published: February 2022

The article provides a literature review of one of the modern medical social problems in the world atopic dermatitis. Epidemiological data, current view on the pathogenesis of this disease, the role of genetic factors and epigenetic mechanisms in the development of dermatosis and modern treatment approaches are highlighted. Atopic dermatitis is a chronic inflammatory skin disease which common for children and adolescents, as well as for adults. Epidemiological studies conducted in different countries reveal the high prevalence and increased incidence of atopic dermatitis over the past three decades. Atopic dermatitis significantly affects the quality of patients and their relatives lives and also results in considerable social and economic burdens. Atopic dermatitis is a heterogeneous disease which pathogenesis is associated with mutations in genes encoding epidermal structural proteins, as well as genes that regulate innate and adaptive immune responses to environmental factors. In addition, the review reflects studies on the mechanisms of epigenetic regulation underlying the development of atopic dermatitis: Deoxyribonucleic acid (DNA) methylation, histone modification, and micro ribonucleic acid (microRNA)-mediated mechanisms of gene expression regulation. Epigenetic modifications in parents are realized in offspring in several generations, causing a wide range of clinical differences in the course of the disease in different age and gender groups. Currently available treatments for atopic dermatitis achieve remission but not a cure. The study of the disease pathogenesis, combined with the continuation of research on finding effective drugs, determines the prospects for developing prevention and treatment of atopic dermatitis.
Asymptomatic bacteriuria in young pregnant women in modern society
Authors: Sitdikova Dinara G. , Fatkullina Irina B , Lazareva Anna Yu , Fatkullina Yulia N , Galiullina Liana A , Fayzullina Liliana A , Galeeva Svetlana A
Published: February 2022

The article provides an overview of the literature and existing international and national Guidelines on the etiology and main pathogens characteristics of asymptomatic bacteriuria, diagnostic criteria, management of young pregnant women with asymptomatic bacteriuria and antibacterial therapy regimens. Young pregnant women are a significant part of the society structure that requires protection. Young women in the age category of 1517 years are identified as a group with a high risk of complications during pregnancy, delivery and the postpartum period, as well as perinatal pathologies. Women of this age group are characterized by a high risk of complications: the threatened miscarriage, premature birth as well as young pregnancies usually accompanied by sexually transmitted infections. It is important for this group of patients to be more carefully monitored by doctors in the hospitals, maternity welfare centers, during delivery and postpartum period. The main causative agents of asymptomatic bacteriuria in pregnant women are representatives of the Enterobacteriaceae family (88.0%). E. coli, Klebsiella spp., Staphilococcus spp. cause asymptomatic bacteriuria only in 310% of cases. The diagnosis is based on the Russian Clinical Guidelines for Urology and the Federal Clinical Guidelines 2020, as well as on the European Guidelines of the Urologists Association 2020. The National Guidelines indicate the main principles of asymptomatic bacteriuria treatment in high risk patients (pregnant and young). Despite the progress made in the urinary tract infections study, especially asymptomatic bacteriuria in pregnant women, and the development of practical Guidelines for the management of these patients, this issue remains important in modern society.
Postinfectious autoimmune encephalitis with opsoclonus-myoclonus syndrome
Authors: Gaifutdinov Rustem T , Matveeva Tatyana V , Zalyalova Zuleikha A
Published: February 2022

Opsoclonus is irregular chaotic eye movements, accompanied by impaired gaze fixation, oscillopsia and associated visual impairment. It is combined with myoclonus of the extremities, trunk, change in gait. It occurs in many pathological conditions, most often in oncological and post-infectious diseases. The rarity and uncommonness of the clinical manifestations of the opsoclonus-myoclonus syndrome, as well as the poor awareness of doctors about this pathology, cause diagnostic difficulties and errors. This report presents the case of a 49-year-old patient, who developed unsteadiness when walking, opsoclonus, myoclonus, startle syndrome, exaggerated startle response 3 weeks after an acute intestinal infection. The diagnostic errors made were analyzed. The diagnosis Post-infection autoimmune encephalitis was proposed and substantiated. Paraneoplastic opsoclonus-myoclonus syndrome was excluded by prospective observation of the patient for 6 years. High efficiency of glucocorticoid treatment was noted.
Assessment of the acute bronchodilator test and the efficacy of the course of treatment with Glycopyrronium bromide in patients with pulmonary tuberculosis associated with chronic obstructive pulmonary disease
Authors: Yaushev Marat F , Alexeev Alexey P
Published: February 2022

Background. Despite significant progress in the fight against tuberculosis, the number of new cases in the world remains relatively stable, and amounts are more than 10 million annually. Chronic obstructive pulmonary disease (COPD) negatively affects the quality of life in patients with pulmonary tuberculosis and reduces the effectiveness of chemotherapy. Correction of bronchial obstruction in pulmonary tuberculosis remains an actual problem.
Aim. To assess the acute bronchodilator test with glycopyrronium bromide, pulmonary function test parameters changing within 24 hours after inhalation, as well as the effect of a 23-month course of treatment with glycopyrronium bromide on the same parameters and the quality of life in patients with pulmonary tuberculosis associated with chronic obstructive pulmonary disease.
Material and methods. A prospective cohort study of 38 patients with active pulmonary tuberculosis associated with the chronic obstructive pulmonary disease treated with anti-tuberculosis chemotherapy was carried out. The pulmonary function test parameters were assessed before inhalation, 15, 30, 120 min, 23 h 45 min after a single inhalation of glycopyrronium bromide, as well as after 1, 2 and 3 months of treatment. Quality of life was assessed by using CAT (COPD Assessment Test), SF-36 (Short Form-36 Health Survey Questionnaire), SGRQ (St. Georges Respiratory questionnaire).
Results. A single inhalation of 50 g glycopyrronium bromide led to a significant increase in forced expiratory volume in 1 second by +15.2%, +18.3%, +22.8% and +11.2% after 15, 30, 120 minutes and 23 h 45 min, respectively. The change in forced expiratory volume in 1 second after 1, 2 and 3 months of treatment was +13.1%, +9.3% and +11.7%, respectively. The overall CAT score after 3 months decreased by 7. The mental health index SF-36 increased by 9.2 points. A decrease in SGRQ parameters was revealed: symptoms by 21.7 points, physical activity by 14.8 points, impact by 18.2 points.
Conclusion. Inhaled glycopyrronium bromide 50 g once daily can be recommended for the treatment of patients with active pulmonary tuberculosis associated with chronic obstructive pulmonary disease.
The effectiveness of three-step treatment for keratoconus with correction of associated ametropia
Authors: Maharramov Polad M
Published: February 2022

Background. Keratoconus is a progressive ectatic disease with thinning and bulging of the cornea structure. It is characterized by a bilateral and usually asymmetric course, which is manifested by the formation of irregular astigmatism. Several different combinations of treatments are currently being used to stop the progression of keratoconus and increase visual acuity.
Aim. To assess the effectiveness of three-step treatment for progressive keratoconus to stabilize the cornea, eliminate its irregularity and achieve maximum visual acuity.
Material and methods. A triple combined treatment was applied to 48 patients (24 women and 24 men) with stage 23 keratoconus (67 eyes) aged 1631 years (mean age 24.40.21 years) at the National Center of Ophthalmology named after Academician Zarifa Aliyeva between 2017 and 2019. It consisted of intrastromal corneal ring implantation, corneal crosslinking after 24 hours, and topography-guided transepithelial photorefractive keratectomy (PRK) after 8 months. All patients underwent complex examinations: uncorrected visual acuity and best spectacle-corrected visual acuity, autorefractometry, non-contact tonometry, corneal topography, tomography, optical coherence tomography of the anterior segment, ultrasound pachymetry. The statistical significance of the difference between the data before and after treatment was assessed by using analysis of variance in the data analysis package of the Microsoft Excel software.
Results. Uncorrected visual acuity before surgery was 0.20.041 and ranged between 0.04 and 0.3. Twelve months after surgery, uncorrected visual acuity significantly improved in all patients; its average value was 0.50.048 and ranged between 0.2 and 0.7. An improvement was observed in best spectacle-corrected visual acuity, which ranged between 0.20.5 before surgery and 0.40.8 after surgery. After intrastromal corneal ring implantation + corneal crosslinking + topography-guided transepithelial-PRK, residual refractive errors of the cornea were eliminated. The maximum keratometry (Kmax) decreased from 46.157.3 D to 42.149.9 D (M and SD before surgery 50.01.5 and after surgery 45.21.4, p=0.009), astigmatism also decreased from 5.259.25 to 0.53.25 cyl (M and SD before surgery 4.610.50 and after surgery 4.180.48, p=0.025). No complications were observed during and in the postoperative period.
Conclusion. The three-step treatment of progressive keratoconus will avoid the need for keratoplasty and achieve maximum visual acuity, minimize the number of aberrations and halts the progression of keratoconus.
Routine scale and polish for periodontal health in adults (Russian Translation of Cochrane Plain Language Summary)
Authors: - -
Published: February 2022

This publication is the Russian translation of the Plain Language Summary (PLS) of the Cochrane Systematic Review: Lamont T, Worthington HV, Clarkson JE, Beirne PV. Routine scale and polish for periodontal health in adults. Cochrane Database of Systematic Reviews. 2018, Issue 12. Art. No.: CD004625. DOI: 10.1002/14651858.CD004625.pub5
Effect of preoperative platelet alpha-granules secretion on hemostasis and blood loss in large joint arthroplasty
Authors: Antropova Irina  P , Yushkov Boris  G , Kutepov Sergey M
Published: February 2022

Background. Currently, it was proven that the role of platelets is not limited to the formation of a clot that stops blood loss and provides vascular wall repair. The importance of determining the functional characteristics of platelets in patients who underwent traumatic surgery is beyond doubt. However, there are few studies on this subject.
Aim. To determine the effect of the preoperative platelet -granules secretory activity on the coagulation parameters and blood loss in total hip arthroplasty (THA).Material and methods. The study included 58 patients admitted to the hospital for primary total hip arthroplasty. All patients were divided into 2 groups according to the preoperative plasma level of the specific platelet -granules protein -thromboglobulin (-TG). The group with a low plasma level of -thromboglobulin (30 IU/ml) consisted of 30 patients, the group with a high level (30 IU/ml) 28 patients. Blood sampling was carried out 1 day before the operation, 30 minutes after surgery, on the 1st, 3rd, 7th 14th days after the total hip arthroplasty. The platelet count, -thromboglobulin, and D-dimer levels were determined. The plasma coagulation was examined by using thromboelastography. The volume of intraoperative blood loss was estimated by the gravimetric method, postoperative blood loss by drainage volume. Statistical analysis was carried out by using the Friedman, Wilcoxon, MannWhitney tests, calculating Spearman's rank correlation coefficient. All calculations were performed using the Statistica 8.0 software.
Results. Before surgery, the group with a high level of -thromboglobulin showed significantly higher levels of D-dimer than the group with low levels: 132 [73; 191] ng/ml and 79 [37; 123] ng/ml (p=0.024); and shorter R times (time to onset of clotting): 13.7 [11.5; 15.3] min and 15.5 [13.0; 18.1] min (p=0.048), respectively. The maximum -thromboglobulin was observed at the end of the operation. The release of -thromboglobulin was significantly more intense in the group with low levels of -thromboglobulin than in the group with high levels: 35.6 [10.5; 78.0] IU/ml and 19.0 [0; 41.3] IU/ml, respectively (p=0.027). A relationship was found between -thromboglobulin levels and D-dimer concentration early after surgery (30 minutes), Spearman's correlation coefficients for groups with low and high levels of -thromboglobulin: r=0.57 and r=0.48, respectively (p 0.05 for both). Blood loss in the group with low -thromboglobulin levels was significantly higher than in the group with high levels: 850 [550; 1050] ml and 600 [500; 850] ml, respectively (p 0.05).
Conclusion. In patients requiring total hip arthroplasty, an increase in the activity of platelet -granules secretion is associated with an increase in the activity of fibrin formation and a shortening of reaction time to onset of clotting; during surgery, the secretory activity of platelets is directly related to the activity of coagulation and affects blood loss volume.
Dynamic assessment of the enzyme immunoassay composition of the oral fluid in children with physiological occlusion and anomalies of the dentition
Authors: Kosolapova Irina V , Dorohov Evgenij V , Lesnikov Roman V
Published: February 2022

Background. Understanding the dynamics of changes in the immunoenzyme composition of the oral fluid at various stages of treatment will allow the doctor to correctly draw up a treatment plan, predict its timing, and prevent the development of complications.
Aim. Dynamic assessment of the enzyme immunoassay composition of the oral fluid in children with physiological occlusion and anomalies of the dentoalveolar system.
Material and methods. The study groups consisted of 125 children aged 612 years with anomalies of the dentoalveolar system receiving treatment with plate and mouth guard orthodontic appliances, and 42 children with physiological occlusion of the dentition. Quantitative determination of total immunoglobulins G, A, M and secretory immunoglobulin A of the oral fluid was carried out before the start of treatment, after 3 and 6 months. Statistical analysis was carried out using IBM SPSS Statistics 20, StatTech v. 1.2.0. ShapiroWilk, KolmogorovSmirnov, KruskalWallis, Dunn with Holm correction, Friedman, Wilcoxon with Holm correction were used.
Results. In patients with anomalies of the dentoalveolar system, a pronounced increase in the content of secretory immunoglobulin A, total immunoglobulin A in the oral fluid during treatment with a kappa apparatus and a pronounced increase in the content of total immunoglobulin M during therapy with a plate apparatus were found. In children with physiological occlusion, there is a dynamic decrease in the content of secretory immunoglobulin A 6 months after the start of observation. These changes indicate the development of a protective mechanism of a specific immune response of the oral cavity when using orthodontic appliances.
Conclusion. As a result of a dynamic assessment of the enzyme immunoassay composition of the oral fluid in children with physiological occlusion, there was a decrease in the content of secretory immunoglobulin A; in children with anomalies of the dentition, a change in the content of secretory immunoglobulin A, total immunoglobulins A and M was found.
Formation of necrotizing vasculitis in the patient with diffuse B-cell large cell lymphoma on immune checkpoint inhibitor (PD-1) therapy
Authors: Mazurov Vadim I. , Melnikov Evgenii S. , Pavlyuchenko Elena S. , Dyakonova Mariya N.
Published: February 2022

INTRODUCTION: Immune checkpoint inhibitors (ICIs) have significantly improved the prognosis and clinical outcomes for patients with malignancies in many types of cancer. Nivolumab is a human monoclonal antibody that blocks the interaction between PD-1 and PD-L1/2, thereby preventing inhibition of T-cells, which contributes to the antitumor response. The use of ICT can lead to autoimmune aggression and the development of adverse events. Most of these are eliminated on their own after ICT therapy and steroid treatment have been discontinued.
CLINICAL CASE DESCRIPTION: A 73-year-old patient with recurrent large B-cell lymphoma, on the background of R-CHOP, R-CHOP-mini, R-GDOx therapy incomplete clinical effect and frequent relapses have been registered. On immunohistochemistry, PD-L1 was positive in 90 % of the tumor cells. A decision has been made to administer the checkpoint inhibitor (PD-1) nivolumab, which developed a necrotizing vasculitis after three injections.
CONCLUSION: On temporary withdrawal of the drug and administration of prednisolone at a dose of 1 mg/kg/day, the skin has recovered completely. When the PD-1 inhibitor was reapplied, there was no recurrence of autoimmune aggression. The treatment has been continued in the full way.
Estimating possibility of applying the modified cumulative illness rating scale (CIRS-Obs) for predicting postpartum infections and antimicrobial resistance
Authors: Korobkov Nikolay A. , Bakulina Natalya V. , Repina Margarita A.
Published: February 2022

BACKGROUND: In obstetrics, there are no systems or scales for assessing somatic burden, predicting and choosing empirical antibiotic therapy in postpartum (postoperative) pyoinflammatory complications.
AIM: The given research aims to assess the reliability and validity of the Cumulative Illness Rating Scale for Obstetrics (CIRS-Obs), which has been firstly modified for obstetric patients. The study is based on the inclusion of additional variables that may be used as highly informative predictors of the development of infectious complications resistant to antibiotics following caesarean section to assess the prognosis.
MATERIALS AND METHODS: A retrospective study of 406 clinical records of obstetric patients suffering endometritis following caesarean section and admitted to the Gynecology department of the Mariinskaya Municipal Hospital has been carried out during the period from September 2008 to September 2020. Multivariate regression analysis allowed to establish a number of indicators characterized by a high predictive value in relation to the unfavorable course of postpartum infections and the isolation of multidrug-resistant pathogens in patients with aggravated somatic status. The most significant factors have been included in the variant of the cumulative comorbidity index (CIRS-Obs), which was firstly modified by the authors for obstetric patients.
RESULTS: The most significant predictors associated with a high risk of isolating resistant and multidrug-resistant pathogens in the examined patients suffering endometritis include CIRS score 4 points, an emergency caesarean section in combination with a prolonged labor and a period without amniotic fluid, antibiotic therapy in the third trimester of pregnancy, as well as previous hospitalizations during pregnancy/invasive procedures or operations.
CONCLUSIONS: The CIRS-Obs scale modified for obstetric patients by including highly informative predictors and developed to assess the risk of isolating resistant and multi-resistant pathogens in obstetric patients suffering endometritis following cesarean section in terms of a patients somatic status, antibiotic therapy, the category of urgency and conditions of the operation allows to increase the reliability of the prognosis to make efficient therapeutic decisions.
Systemic transtiretin amyloidosis in the elderly patient with recurrent pleural effusions
Authors: Boldueva Svetlana A. , Evdokimov Dmitriy S. , Shvets Natalia S. , Shahbazyan Anahit V. , Kalinina Elena Yu. , Mitrofanova Lyubov B.
Published: February 2022

Systemic amyloidosis is a group of diseases associated with extracellular deposition of fibrillar proteins, which leads to a loss of normal organ structure and function. Transthyretin amyloidosis occurs with the deposition of amyloid, consisting of transthyretin transport protein, and can be a genetic or degenerative disease of senility (acquired from the deposition of wild-type transthyretin).
The article describes the clinical case of transthyretine amyloidosis in elderly patient, manifested by recurrent pleural effusions and biventricular heart failure demonstrating the complexity of timely diagnosis of wild-type transthyretin amyloidosis.
Coexistent rheumatoid arthritis and hyperuricemia: clinical and immunological features
Authors: Mazurov Vadim I.N. , Gaydukova Inna Z. , Fonturenko Aleksandra Yu. , Bashkinov Roman A. , Petrova Marianna Semenovna , Inamova Oksana V.
Published: February 2022

BACKGROUND: Currently, the negative role of asymptomatic hyperuricemia (HU) in the development and progression of cardiovascular pathology, metabolic disorders and chronic kidney disease is generally recognized. There is not much data in the literature on the effect of HU on the course of rheumatoid arthritis (RA), therefore, the study of the relationship of HU with clinical, radiological and immunological features of RA seems relevant.
AIM: To study the relationship between HU with the clinical, radiological and immunological features of RA.
MATERIALS AND METHODS: The data of 262 patients with RA and HU and 262 with RA without HU (comparison group) included in the city register from January 2000 to April 2020 have been analyzed. The information included demographic features (gender, age), diagnosis, presence and duration of HU, duration of observation, disease activity, laboratory, immunological, radiological and functional parameters, therapy of the underlying disease. HU was understood as a recorded 1-fold increase in the level of uric acid (UA) in the blood serum 360 mmol/l. The study has been approved by the local ethics committee.
RESULTS: The data of 524 patients with rheumatoid arthritis for the period from January 2000 to April 2020 have been analyzed. The study included 440 women and 84 men. The average age of the patients was 60.0 13.6 y. The patients with HU have been divided into two subgroups: the first with the level of UA less than 500 mmol/l, the second with the level of UA more than 500 mmol/l. The number of males was significantly higher among the patients with high HU than among the patients with low HU and the comparison group. Every third patient had significant structural changes in the joints (radiological stage III-IV) and 98% of the patients had moderate and pronounced functional limitations (functional class 2-3). The patients with HU were older, had more follow-up visits, were observed for a longer period of time, had a lower frequency of radiological progression, a greater number of painful and swollen joints, less often and at a smaller dose had methotrexate and more often sulfasalazine in comparison with the patients without HU (p 0.05).
CONCLUSIONS: 1) Thus, we can emphasize the negative impact of hyperuricemia on the course of rheumatoid arthritis: if it is present, there are direct (more PJ, SJ) and indirect signs of a more severe course (longer duration of observation and the number of visits). 2) Immunosuppressive therapy is associated with the absence of differences with the generally recognized markers of disease activity (ESR, CRP, DAS28), the immunological profile (RF, ACCP) and the ambiguous relationship with radiological progression and functional insufficiency of the joints, as well as unreliable relationship with a higher frequency of bone density reduction.
Drug-induced diarrhea associated with antineoplastic drugs
Authors: Sychev Dmitry A. , Ostroumova Olga D. , Ziganshina Liliya E. , Filippova Anastasiya V.
Published: February 2022

Diarrhea is the most common adverse reaction of anticancer drugs, as well as radiation therapy of the pelvic organs or abdominal cavity: the incidence of diarrhea of different seveity reaches 80% during chemotherapy and / or radiation therapy; one third of these patients develop severe diarrhea (3rd or 4th degree). Most often, drug-induced diarrhea occurs during chemotherapy, using 5-fluorouracil or irinotecan, taking new anticancer drugs from the classes of checkpoint inhibitors, monoclonal antibodies, tyrosine kinase inhibitors. The most common mechanisms underlying the development of drug-induced diarrhea are damage to the intestinal mucosa, impaired absorption of proteins, carbohydrates, fats, inflammation, a perverse immune response, microflora imbalance, and others.
Algorithms for the management of patients with severe diarrhea include suspension (grade 1-2, 3) or complete cessation (grade 4, grade 3) of the use of an antineoplastic agent an inducer, prescribing drugs that reduce intestinal motility (loperamide) while excluding the infectious nature of diarrhea, intravenous methylprednisolone (for example, diarrhea caused by monoclinal antibodies in the absence of suspicion of potential bowel perforation). In cases where drug-induced diarrhea lasts more than 48 hours, or a patient reports symptoms of dehydration, or a fever occurs, urgent hospitalization is necessary.
The objective of this review is to analyze scientific literature data on the prevalence, pathophysiological mechanisms and risk factors for the development of diarrhea associated with the intake of anticancer drugs, as well as its prevention and treatment.
Characterization of Rhizospheric Bacillus Strains SG36 and SG42 for Decolorization of Reactive Yellow 2 Dye and Vigna radiata Growth Promotion in Dye Contaminated Soil
Authors: Bilal Yasir
Published: February 2022

Contamination of agricultural soils with textile wastewaters loaded with synthetic dyes is one of the emerging issues because the presence of dyes in the soils not only affects the biological characteristics of the soils but also the germination and productivity of agricultural crops. The present study reports the characterization of two multifunctional bacterial strains Bacillus sp. SG36 and Bacillus sp. SG42, which have the potential not to promote the growth of plants in soil under stress due to reactive yellow 2 (RY2) dye but also the capability to cope with this dye through its decolorization. The strains were isolated from a rhizospheric soil repeatedly contaminated with colored textile wastewaters. Both the strains had optimal RY2 decolorization potential at slightly alkaline pH (7.5) and even in the presence of significant amount of NaCl (50 g L-1) in the medium. The strains harbor the phosphorus solubilization and indole acetic acid production potentials in concurrence with decolorization of RY2. In a pot experiment, the strains SG36 and SG42 were found to significantly promote the growth (Shoot/root length, shoot/root fresh weight) of mung bean (Vigna radiate) in non-contaminated and RY2 contaminated soils in parallel with RY2 decolorization in the soil. © 2022 Friends Science Publishers
Modified Atmosphere as an Alternative Measure for Controlling of Sitophilus oryzae Reared on Different Stored Grains
Authors: Mohsin Muhammad
Published: February 2022

Protection of grains and their products from insect pests remained a big constraint in the way of food security. Current study evaluated the effective exposure time to kill the Sitophilus oryzae (L.), reared on two different diets viz., wheat and maize under six Carbon dioxide (CO2) concentrations. Modified atmospheres (MA) contained 25, 30, 35, 40, 45 and 50% CO2 by volume at ambient temperature, respectively. Twenty S. oryzae adults, along with a 20 g diet, were released in each airtight exposure chamber (150 mL capacity). A measured quantity of CO2 gas (99.9%) was released in exposure chamber by the injection syringe from gas cylinder. Mortality data were recorded after 24, 48, 72, 96 and 120 h. The mortality rates varied between the insect cultures reared on maize and wheat diets. S. oryzae, reared on a wheat diet, showed higher mortality after exposure to all CO2 concentrations as compared to the insect culture reared on the maize diet. At 45% CO2concentration, maximum mortality (100%) was observed after 120 h in case of maize reared insects and (100%) after 96 h in case of wheat reared S. oryzae. The results revealed that Carbon dioxide, as an eco-friendly approach, may be used as the best alternative method to minimize the pest infestation in stored products to avoid insecticide resistance development in stored grain insect pests. The Carbon dioxide is not included in the category of toxic gases and has no detrimental or residual effect in the stored grains. © 2022 Friends Science Publishers
Investigating Structural Relationships among Service Quality Dimensions, Customer Satisfaction, and Customer Loyalty for Conventional Bank Customers: Evidence from Bangladesh
Authors: Miah Md. Shelim
Published: February 2022

Customers of the banks are highly servicing sensitive in Bangladesh. The quality of service has become an integral part of customer satisfaction. Day by day, It has been demonstrated that customer satisfaction and loyalty are linked to service quality. There is also a link between service quality and customer satisfaction, and customer loyalty in banks. Therefore, this paper investigated the effect of service quality factors on customer satisfaction and the relationship between customer satisfaction and customer loyalty in conventional banks in Bangladesh. A survey was conducted on 13 different conventional banks in Bangladesh. Using simple random sampling, 220 customers were selected as a sample from selected conventional banks for this study. The research was carried out using a structured questionnaire. The SPSS software was used to analyze the demographic data. Multivariate analysis technique like Factor Analysis and Structural Equation Modeling (SEM) was used to identify the influential factors for the bank's customer loyalty by using SmartPLS3 software. The study found that all service quality factors such as assurance, reliability, responsiveness, and tangibility are the influential factors except empathy.
Disclosure of Sustainable Development Goals (SDGs) in Bangladesh: A Study on DSE Listed Companies
Authors: Saha Trina , Jannat Fatema
Published: February 2022

Business organizations can secure their future growth by implementing sustainable development goals into their business process. With the advancement in accounting, the nature of reporting practices is also changing. Now reporting is not merely restricted to financial statements, information related to social contribution, environment; sustainability has attained much interest in the corporate world. This study aims to find out the nature and extent of reporting practices of SDGs by some listed companies of the Dhaka Stock Exchange. The samples of this study are 40 companies from several sectors, including banks, pharmaceuticals, insurance, ceramics, telecommunication, etc. are selected based on market volume. Content analysis based on 16 recommendations under governance, strategy, management approach, and performance and targets found from an extensive literature review has been made to fulfill the research objectives. Annual reports from 2019 to 2020 are examined to determine the disclosure issues based on given recommendations. The findings reveal the minimum level of direct disclosure of SDGs but a satisfactory level (around 87.5%) of exposure about the consciousness of SDGs and involvement of SDG in strategy (approximately 63.75%). This study is pioneering because there is very little research about it in our country; thus, it is expected to encourage more research on this subject. JEL Classifications: G10, G38, I38
Vehicle Tracking Application Based on Real Time Traffic
Authors:   Institute of Computer Science & Digital Innovation (ICSDI), UCSI University, Kuala Lumpur, Malaysia, Shibghatullah Abdul S. , Jalil Abdurrahman , Wahab Mohd H. Abd , Soon Joseph Ng Poh , Subaramaniam Kasthuri , Eldabi Tillal
Published: February 2022

Vehicle tracking application is very important to track the movement of vehicles such as bus, train and taxi. One of the issues in vehicle tracking system is the accuracy of estimation time. With the help of technology, it is possible for the vehicle operators to provide accurate estimated time of arrival to the users. This paper aims to improve the accuracy of vehicle estimated time so that users can expect the arrival of the vehicle. An application is proposed in this paper and it uses Global Positioning System (GPS) on Android smartphone to determine the location of a vehicle and the coordinates is stored in Firebase Real-time Database which optimized for syncing of data in real-time. Furthermore, Google distance matrix Application Programming Interface (API) is used to calculate the estimated arrival time of the vehicle. Distance matrix API is able to return time of travel between two points, based on recommended route and traffic information. The prototype of application went through several stages of software testing and evaluation. Based on the users feedback the system is better in terms of estimating the arrival time.
A clinical study comparing the accuracy of the clinical examination, ultrasonography, fine needle aspiration cytology with that of histopathology
Authors: Abbaraju Sasidhara Rao , Sridhar Punyapu , Kota Sameera , Farooqi Zainab , Panguluru A. S. Nikhil Mehra
Published: February 2022

Background: Fine needle aspiration cytology (FNAC) is considered the gold standard diagnostic test for the diagnosis of thyroid nodules. FNAC is a cost-effective procedure that provides specific diagnosis rapidly with minimal complications. Aims was to compare efficacy of Clinical diagnosis, ultrasonography (USG), FNAC with one another and with that of histopathological examination (HPE) diagnosis.Methods: It is a prospective comparative study in 60 patients admitted with thyroid swellings in the department of General Surgery were taken for study purpose. The clinical diagnosis, ultrasonogram report, FNAC and HPE were included in the study.Results: Thyroid disease is 4.54 times more common in females. Thyroid disease is more common in the reproductive age group with the mean average age of 37.91±11.02 years. The male:female sex ratio for carcinoma is 1:2.33. Benign thyroid disorders constitute 83.3% of the total thyroid disorders. The overall efficacy of FNAC (88.33%) is far higher than USG (76.66%) and clinical diagnosis (56.66%). Sensitivity for diagnosis of thyroiditis clinically is very poor (45.45%) as compared to diffuse goiter (71.43%). FNAC can reasonably differentiate benign from malignant lesion most of the time with sensitivity of about 90%.Conclusions: Ultrasonogram alone cannot correctly diagnose different types of benign lesions with accuracy. However, it can most of the time differentiate benign from a malignant lesion. It has an overall efficacy of 76.7%. The efficacy of FNAC is nearly 90% making it an essential diagnostic tool for diagnosing thyroid disease.
Nutritional overview of non-critical COVID-19 patients during quarantine in a premier hospital of India
Authors: Kaur Parmeet , Rahman Ghazala , Pandey Veena
Published: February 2022

Corona virus disease (COVID-19) is a recent global disease. During hospital quarantine of non-critical COVID-19 patients, specific attention is given on their general management and little is known regarding the nutritional approach. The present study was therefore conducted to assess their dietary predilections during hospital quarantine.

A prospective observational study was conducted in non-critical COVID -19 patients admitted in isolation wards of All India Institute of Medical Sciences (AIIMS), New Delhi from 1 November 2020 to mid of January 2021. A dietician administered a pre validated questionnaire telephonically to obtain data regarding demographic, anthropometric and dietary characteristics. The results were expressed as mean, standard deviation and median. Chi square tests were used to compare category variables. Statistical analysis was performed using SPSS 9 version 20.0.SPSS, Inc., Chicago IL).

132 patients volunteered to enrol in the study. The mean age of patients was 34.6 +13.5years. Portion size of foods served and number of food groups in breakfast, lunch and dinner as per standard diet scale for balanced hospital diet, did not differentiate by BMI categories (Pearson’s x>0.05). The mean body mass Index (BMI) was 23.75+4.15. Being overweight and obese correlated with taste issues (Pearson’s x< 0.05). Additional centre of attention on fruits, vegetables, fluids and proteins

Owing to the recent growing COVID-19 situation, the findings of the present study may be utilized in developing the most favourable nutritional strategies within the inpatient hospital menu for providing enhanced nutritional care.
Evaluation of immunoglobulin M and A level in individuals with HIV-TB co-infection in NAUTH, Nnewi
Authors: Ogbodo EC , Ezeugwunne IP , Mbachu N , Arinzechi PC , Analike RA , Uduchi IO , Izuchukwu ECO , Nduka NS
Published: February 2022

This study evaluated the serum concentrations of Immunoglobulin M and Immunoglobulin A in individuals with TB, HIV and HIV-TB co-infection in Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi South East, Nigeria. A total of 80 participants (males=44; females=36), with a mean age of 35.83±7.3 were randomly recruited by convenient sampling technique from patients attending TB-DOTS and HIV Clinics in NAUTH and grouped as: TB positive individuals (Group I), HIV-TB co-infection (Group II), HIV positives (Group III), and control (Group IV). 5mls of venous blood samples were collected from each participants using plain containers for estimation of immunoglobulin A and M classes by Immuno-turbidimetric Method. The results obtained showed that mean serum levels of IgM (78.14±42.41 and IgA (374.45±15.69) were significantly increased in participants with HIV-TB co-infection when compared with TB (49.21±3.67) and (315.41±52.79), HIV (41.91±25.97) and (342.23±92.67 and control groups (55.82±35.36) and (322.66±71.34) at p<0.05 respectively. There were significant increases in the mean serum IgM (p=0.048), IgA (p=0.000) and age (p=0.001) when group I participants were compared with group II individuals respectively, while IgM showed significant increase (p=0.013) in group II than in group III only. Furthermore, participants in group II showed significantly increased mean serum IgA levels compared to control (p=0.005), whereas significant negative correlations were seen in age and gender in various groups studied (p<0.05). Thus, evaluation of these antibodies may be used alongside other systemic markers and parameters to aid in predicting disease severity and progression and also monitoring response to treatment. This approach could further complement the current TB management especially in HIV-TB co-infection.