bluuebunny/crossref_metadata_2025 huggingface dataset:
A poszttraumás stressz szindróma gazdasági terhe: szisztematikus irodalmi áttekintés
Authors: Ferenczik Anikó
Published: September 2024

A poszttraumás stressz szindróma (PTSD) az egyik olyan pszichiátriai betegség, ami az egészségügyi ellátó rendszer szélesebb körű használatához vezethet, azonban kevés ismerettel rendelkezünk arról, hogy milyen betegségteher vizsgálatok állnak rendelkezésre ehhez kapcsolódóan. Magyarországi költségelemzést eddig nem publikáltak a PTSD betegségterhével kapcsolatosan és nemzetközi szinten is kevés, módszertanilag rendkívül heterogén szakirodalom áll csak rendelkezésre. A tanulmány célja, hogy betöltse ezt az űrt és szisztematikusan áttekintse a PTSD betegségterhével foglalkozó szakirodalmat. Kutatásom során Medline-keresést végeztem 2022. augusztusig bezárólag, mely során a beválogatási kritériumok a következők voltak: (1) eredeti közlemények, (2) angol nyelvű absztrakttal, melyek (3) költségelemzést jelentettek PTSD-ben. Az így kiválasztott 15 tanulmány közül mindegyikben részletesen tárgyalták a direkt egészségügyi költségeket, két tanulmányban elemezték a direkt nem egészségügyi költségeket is, ideértve az informális ellátás költségeit, két további cikk az indirekt költségeket is vizsgálta. A tanulmányok széles skálán mutattak ki költségkülönbségeket: az egy betegre jutó éves direkt egészségügyi kiadások Ausztráliában 4 461 és 43 362 EUR között mozogtak, az Egyesült Államokban 2 442 és 35 967 EUR között, míg Európában 217 és 36 204 EUR között változtak. Szintén jelentős eltéréseket tapasztaltak a direkt nem egészségügyi költségek terén, ahol az összegek 98 és 9 372 EUR között mozogtak. Az indirekt költségek tekintetében a legalacsonyabb összeg 2 918 EUR, míg a legmagasabb 11 061 EUR volt. A tanulmányokból továbbá kiderült, hogy a gépjármű balesetet és a bántalmazást követő PTSD-ben figyelték meg a legmagasabb költségeket, de a betegség súlyossága is szignifikánsan növeli a keletkező költségeket volumenét.
Tax Capacity and Tax Effort: Evidence From Albanian Economy
Authors: Liko Elida , Kola Tonin
Published: September 2024

The potential tax capacity is very important for assessing the tax space for policy response, especially after the COVID-19 crisis. The main objective of this paper is to study the tax capacity of the Albanian economy, relative to other transition economies with the same patterns of development. We rely on a regression-based approach for the period of 1998-2022 to estimate the potential tax capacity and tax effort. The study found that the structure of the economy, per capita income, openness to foreign trade and corruption are the most consistent explanatory variables of the potential tax capacity. The study also found that tax effort is below one for the Albanian economy, and tax-to-GDP collections are below the average level of the transition economies. We conclude that the country should continue improving the governance quality and fighting corruption to improve tax collection. The study does not support further increases in the statutory tax rates.
Az európai versenyképesség csak közösségi szinten növelhető, nemzeti keretekben nem – Interjú Dr. Csaba László akadémikussal, a Köz-gazdaság szerkesztőbizottságának tagjával
Authors:   Köz-gazdaság, Csaba László
Published: September 2024

Csaba László magyar közgazdász, egyetemi tanár, a Magyar Tudományos Akadémia rendes tagja. Kutatási területe a világgazdaságtan, ezen belül az összehasonlító gazdaságtan, vala- mint a nemzetközi gazdasági kapcsolatok. Számos magyar és angol nyelvű monográfia és tudományos publikáció szerzője. 1990 és 1994, valamint 1996 és 1998 között az Európai Gazdaság-összehasonlító Társaság alelnöke, 1999 és 2000 között pedig annak elnöke volt. Többek között az Acta Oeconomica, a Közgazdasági Szemle, a Külgazdaság, a Russian and East European Finance and Trade, a Europe–Asia Studies, az Intereconomics című tudomá- nyos szakfolyóiratok szerkesztőbizottságának tagja. 1984-ben védte meg a közgazdaság- tudományok kandidátusi értekezését a Magyar Tudományos Akadémián, majd 1994-ben megjelent „Az összeomlás forgatókönyve” című könyve, amivel 1996-ban az MTA doktora címet nyerte el. 2007-ben a Magyar Tudományos Akadémia levelező, 2013-ban rendes tag- jává választották. 2012 szeptemberében a Science Europe (Brüsszel-Berlin), 2013 szeptem- berében a londoni székhelyű Academia Europea tagja lett. Fő kutatási területe a világgazdaságtan, ezen belül az összehasonlító gazdaságtan, va- lamint a nemzetközi gazdasági kapcsolatok. Tudományos munkásságának kezdetén Kelet-Európa gazdaságtanával foglalkozott, majd a magyar és más rendszerváltások ös - szehasonlító gazdaságtanával foglalkozott (pl. a gazdasági liberalizáció, a privatizáció és az átmenet problematikája). Ezt követően a közép-kelet-európai politikai gazdaságtan kér- déseiről publikált, majd a magyar kis- és középvállalkozói szektor, a kisebb gazdaságok és Európa világgazdasági kérdéseit és összefüggéseit kutatta. Közel 350 tudományos közleménye összesen tizennyolc országban jelent meg. Publiká- cióit számos könyv, illetve gyűjteményes kötet formájában adták ki. Munkáit elsősorban magyar és angol nyelven adja közre.
Az érdem zsarnoksága
Authors: Nagy Konrád Ákos
Published: September 2024

Idén jelent meg magyarul a neves filozófus, Michael Sandel könyve „Az érdem zsarnoksága” címmel. Az „A válogatógép” című fejezetben egy izgalmas javaslatot tesz az amerikai egyetemi felvételi rendszer megreformálására. A Yale egy korábbi felvételi bizottsági tagjának 1960-ban tett megjegyzését idézi, aki azt mondta, néha úgy érzi, teljesen véletlenszerűen is választhatnának a jelentkezők közül, legalább ugyanilyen minősége lenne a szakoknak. Sandel ebből kiindulva azt mondja, érdemes lenne egy felvételi küszöbértéket meghatározni, és aki azt megugorja, bekerül a kalapba, ahonnan véletlenszerűen választják ki az egyetemre bejutókat (Sandel, 2024).
Kerekasztal-beszélgetés a kiberbiztonságról
Authors: Nagy Konrád Ákos
Published: September 2024

Az óbudai egyetemen kkv-k kiberbiztonsági felkészültsége, dilemmái témában került megrendezésre kerekasztal-beszélgetés Trautmann László vezetésével. A résztvevők: Pintér Róbert (Budapesti Corvinus Egyetem adjunktusa, Digiméter kutatásvezetője), Katona Gergely (Nemzeti Közszolgálati Egyetem), Kott Ferenc (MKIK Digitalizációs Kollégium vezetője, BKIK Informatikai Osztály elnöke), Márton János (Falcon ügyvezetője), Répás József (Alverad vezetője).
Theoretical and applied aspects of A/B testing in a modern company
Authors: Zhigulev Petr
Published: September 2024

The article is devoted to the study of theoretical and applied aspects of conducting A/B testing in a modern company in the context of decision-making within the product strategy. It describes A/B testing as a method of marketing research, clarifies the advantages of A/B testing and criteria for its conduct, and identifies prospects for improving the results of A/B testing. An algorithm for conducting A/B testing is formulated, following which it is possible to obtain sufficiently reliable results, taking into account the specific features of the company and the parameters set. It is emphasized that conducting A/B testing also requires consideration of the specific context, objectives of the company's product or marketing strategies, and the characteristics of the target audience, which allows for improving the effectiveness of A/B testing. The conclusion of the study is that this method is highly valuable from the perspective of product development of a company, as A/B testing becomes a significant tool in supporting decision-making and allows for product development while reducing the costs necessary for analyzing the effectiveness of its test versions.
On the Issue of Preparing and Implementing a Product Strategy
Authors: Zhigulev Petr
Published: September 2024

This article is dedicated to exploring the theoretical essence, aspects, and trends in preparing and implementing a product strategy in the activities of companies at the current stage. It provides a theoretical description, the concept, and contemporary product strategies. The presence of a connection between strategic management and the development of a product strategy is highlighted. It is emphasized that the process of implementing a product strategy presupposes its reproduction in practice, taking into account the specific stage, changes, and market dynamics. A typical algorithm for preparing a product strategy is characterized, broadly reflecting practical recommendations, relying on which companies will be able to prepare their own product strategies. The research concludes with general trends in the preparation and implementation of product strategies by domestic companies, among which are: a high level of customer orientation; the ambition to reduce the level of costs (focus on price competition); replacement of imported products and promotion of "domestic products".
Real-World Effectiveness and Use of Dupilumab in Eosinophilic Esophagitis
Authors: Russin Michelle , Chen Joan , Rubenstein Joel H. , Chang Joy W.
Published: September 2024

INTRODUCTION:

Dupilumab, the first US Food and Drug Administration–approved treatment for eosinophilic esophagitis (EoE), lacks real-world data on use and effectiveness.

METHODS:

We conducted a retrospective cohort study of 70 patients with EoE prescribed dupilumab, comparing prescriber type, indication, follow-up, and response.

RESULTS:

Indications varied with gastroenterologists commonly prescribing for treatment-refractory cases and allergists as first-line therapy. Endoscopic assessment was lacking in 25.9%, but those with follow-up showed high histologic remission (92.3% first-line and 85% previous treatment failure).

DISCUSSION:

Dupilumab demonstrates effectiveness across EoE severity, including milder disease without previous treatment failure. Improving follow-up and assessing cost-effectiveness will help clarify its role in the treatment algorithm.
NIKAH BEDA AGAMA: Perspektif Aktifis Jaringan Islam Liberal (JIL)
Authors: Harsono Muhamad
Published: September 2024

Dewasa ini, di Indonesia penikahan beda agama merupakan fenomena di kalangan selebritis,  masyarakat awam, bahkan aktivis dialog antar agama dan kaum agamawan terdidik. Akhir-akhir ini, Paramadina, sebuah lembaga kajian dan kursus intensif agama Islam yang didirikan oleh Nurcholis Madjid menjadi tuan rumah dan mengakui pernikahan pasangan beda agama antara Rudi Pratono (Islam) dan Ana Maria Saraswati (Katholik). Pada bulan Juni 2004, seorang aktifis yang bernama Ahmad Nurcholis (aktifis ICRP yang beragama Islam) menikahi Ang Mei Yong seorang Konghucu. Tulisan ini coba mengetengahkan perspektif Aktifis JIL (Jaringan Islam Liberal) tentang pernikahan beda agama tersebut.
KONTRIBUSI PEMIKIRAN QASIM AMIN DALAM PEMBARUAN HUKUM KELUARGA ISLAM
Authors: Bahri Syaiful
Published: September 2024

This paper attempts to discuss two things. First, the history of family law reform in the Muslim world. Second, Qasim Amin thoughtful contributions to the process of family law reform happening in the Muslim world. The process of family law reform in the Muslim world is not born out naturally. The reform was born due to the fact that the conventional family law is not in accordance with the challenges of the times. The fundamental purpose of Islamic family law reform is to raise the status of women. Even so, the contribution of Qasim Amin in the process of family law reform happening in the Muslim world can be traced from his idea of social reform project (al-Is}la>h} al-ijtima>i). For Amin, the process of social reform would only be successful if there is a family law hasbeen updated and brought in line with the demands of the times. The ideas of family law reform, primarily on three crucial themes, marriage, polygamy, and divorce, have been said in Amin’s first work, Tah}ri>r al-mar’ah (1899).[Tulisan ini mencoba mendiskusikan dua hal. Pertama, sejarah pembaruan hukum keluarga di dunia Muslim. Kedua, kontribusi pemikiran Qasim Amin terhadap proses pembaruan hukum keluarga yang terjadi di dunia Muslim. Proses pembaruan hukum keluarga di dunia Muslim tidak lahir dariruang kosong. Pembaruan tersebut lahir atas adanya kenyataan bahwa hukum keluarga konvensional sudah tidak sesuai dengan tantangan zaman. Sedang tujuan fundamental dari pembaruan hukum keluarga Islam adalah untuk mengangkat status perempuan. Pun demikian, kontribusi Qasim Amin dalam proses pembaruan hukum keluarga yang terjadi di dunia Muslim bisa dilacak dari proyek reformasi sosial (al-Is}la>h} al-Ijtima>’i) yang beliau gagas. Bagi Amin, proses reformasi sosial hanya akan berhasil jika hukum keluarga yang ada sudah diperbarui dan diselaraskan dengan tuntutan zaman. Ide-ide pembaruan dalam hukum keluarga, utamanya terhadap tiga tema krusial, perkawinan, poligami, dan perceraian, sudah Amin cetuskan dalam karya pertamanya, Tah}ri>r al-Mar‘ah (1899).]
TEORI RI’ÂYAH AL-MASLAHAH ÂT-TUFI DAN APLIKASINYA DALAM MENAKAR PROBLEMATIKA IHDAD
Authors: Milati Arifah
Published: September 2024

Ri’a>yah al-mas}lah}ah is the purpose of the law. This theory by Najm ad-Di>n at}-T}u>fi> serve as the first legal considerations in mu’a>malah. Mas}lah}ah considered independent without the support of certain nas even though its meaning is contained in the passages. The theory is clearly different from the theory of the clergy in general. One of the standard system of rules of classical fiqh books to the book of contemporary jurisprudence is ih}da>d. The concept is unique and has been codified in the books of fiqh seems to be the dogmatic rules of grammar can not be questioned over its validity. The concept ih}da>d has been standardized and codified the scholars in their books, the case is not a serious problem when associated with the position of women in the previous era, but if you do a how to find a solution as a meeting point in order to avoid collisions between the ideas that have been classical scholars formulated with the real conditions of life of modern women in the public sector. [Ri’a>yah al-mas}lah}ah adalah tujuan hukum. Teori ini oleh Najm ad-Di>n at}-T}u>fi> dijadikan sebagai pertimbangan hukum pertama dalam bidang mu’a>malah. Mas}lah}ah dianggap independen tanpa didukung nas} tertentu walaupun maknanya sudah terkandung di dalam nas}. Teori tersebut jelasberbeda dengan teori ulama pada umumnya. Salah satu aturan sistem yang baku dari kitab-kitab fikih klasik hingga kitab fikih kontemporer adalah ih}da>d. Konsep yang khas dan sudah dikodifikasi dalam kitab-kitab fikih sepertinya merupakan tata aturan dogmatik yang tidak bisa dipertanyakanulang validitasnya. Konsep ih}da>d telah dibakukan dan dikodifikasikan para ulama dalam kitabkitabnya, kasus tersebut tidak menjadi problem serius bila dikaitkan dengan posisi perempuan pada era terdahulu, namun jika demikian adanya bagaimana mencari solusi sebagai titik temu agar tidak terjadi benturan antara ide yang telah dirumuskan para ulama klasik dengan kondisi riil berupakehidupan perempuan modern di sektor publik.]
KONSEP TALAK: Versus Situs www. darussalaf.or.id dan Undang- Undang Perkawinan di Indonesia
Authors: Fakhria Sheila
Published: September 2024

This paper discusses divorce in the Internet by focusing on the study of Islam is one of the sites www.darussalaf.or.id. An active site that publishes material and also Islamic marriage law required communities, one divorce. On site www. darussalaf.or.id explained that divorce is the husband full rights in conditions of legal age, intelligent, mumayyiz who understand what it does. In addition, the site also explains that a wife is not allowed to ask for divorce without reason Sharai, otherwise the wife is allowed to ask to split up with her husband on the grounds Sharai them if she hates moral ugliness, religion, husband’s physical, and worried not be able to enforce the rights that are required fulfilled when her husband live with her. Therefore, it is necessary to study the extent to which the relevance of the concept of the validity of a divorce between sites www.darussalaf.or.id and marriage laws in Indonesia.[Tulisan ini membahas tentang talak dalam internet dengan memfokuskan kajian pada salah satu situs islam yaitu www.darussalaf.or.id. Sebuah situs yang aktif mempublikasikan materi keislaman dan juga hukum perkawinan yang dibutuhkan masyarakat, salah satunya talak. Pada situs www.darussalaf.or.id dijelaskan bahwa talak merupakan hak sepenuhnya suami yang dalam kondisibaligh, berakal, mumayyiz yang mengerti dengan apa yang dilakukan. Selain itu, situs ini juga menjelaskan bahwa seorang istri tidak diperkenankan meminta cerai tanpa alasan yang syar’i, sebaliknya seorang istri diperbolehkan meminta untuk berpisah dengan suaminya dengan alasan syar’i diantaranya jika dia membenci kejelekan akhlak, agama, atau fisik suaminya, serta khawatir tidak mampu menegakkan hak-hak suaminya yang wajib ditunaikannya ketika hidup bersamanya. Oleh karena itu perlu dikaji tentang sejauh mana relevansi konsep keabsahan talak antara situs www.darussalaf.or.id dan undang-undang perkawinan di Indonesia.]
Corrientes actuales en el estudio del judaísmo rabínico y su relación con el Nuevo Testamento
Authors: Delgado Gómez Alfredo
Published: September 2024

El uso de los textos rabínicos como herramienta para conocer mejor el contexto en el que surgió el cristianismo primitivo tiene una larga historia, la cual continúa en recientes publicaciones. El cambio de paradigma en el estudio de los textos rabínicos suscitado por Neusner tuvo como consecuencia el cuestionamiento de su fiabilidad para reconstruir el comienzo del judaísmo rabínico. Sin embargo, los recientes avances en la investigación sobre el judaísmo rabínico no consiguen permear en muchos de los estudiosos del N. T., que siguen utilizando estos textos de manera acrítica, dando lugar a visiones erróneas sobre el judaísmo del segundo templo, los fariseos y el judaísmo rabínico. Este estudio actualiza el estado de la investigación sobre el judaísmo rabínico y plantea unas consideraciones para su uso en el estudio del N. T.
Effects of Collocational Congruency, Frequency and L2 Proficiency on the Processing of English Adjective-Noun Collocations
Authors: Yang Lianrui , Zhang Qun , Li Ni , Chen Ying
Published: September 2024

The present study investigates the effects of congruency and frequency on adjective-noun collocational processing for Chinese learners of English at two proficiency levels based on the data obtained in an online acceptability judgment task. The subject pool of this research included 60 English majors studying at a university in China; 30 were selected as a higher-proficiency group and 30 as a lower-proficiency group according to their Vocabulary Levels Test (Schmitt et al., 2001) scores and their self-reported proficiency in English. The experimental materials were programmed to E-prime 2.0 and included six types of collocations: (1) 15 high-frequency congruent collocations, (2) 15 low-frequency congruent collocations, (3) 15 high-frequency incongruent collocations, (4) 15 low-frequency incongruent collocations, (5) 15 Chinese-only items, and (6) 75 unrelated items for baseline data. The collected response times (RTs) and accuracy rates data were statistically analyzed by the use of an ANOVA test and pairwise comparisons through SPSS 16.0 software. The results revealed that: (1) the adjective-noun collocational processing of Chinese English learners is influenced by collocational frequency, congruency and L2 proficiency; (2) the processing time is affected by the interaction of congruency and frequency; and (3) the interactive effect of L2 proficiency in conjunction with congruency and frequency also influences the processing quality.
Text Difficulty, Working Memory Capacity and Mind Wandering During Chinese EFL Learners’ Reading
Authors: Gao Xianli , Li Li
Published: September 2024

This experimental study investigated how text difficulty and different working memory capacity (WMC) affected Chinese EFL learners’ reading comprehension and their tendency to engage in task-unrelated thoughts, that is, mind wandering (MW), in the course of reading. Sixty first-year university non-English majors participated in the study. A two-factor mixed experimental design of 2 (text difficulty: difficult and simple) × 2 (WMC: high/large and low/small) was employed. Results revealed that 1) the main and interaction effects of WMC and text difficulty on voluntary MW were significant, whereas those on involuntary MW were not; 2) while reading the easy texts, the involuntary MW of high-WMC individuals was less frequent than that of low-WMC ones, whereas while reading the difficult ones, the direct relationship between WMC and involuntary MW was not found; and that 3) high-WMC individuals had a lower overall rate of MW and better reading performance than low-WMC individuals did, but with increasing text difficulty, their rates of overall MW and voluntary MW were getting higher and higher, and the reading performance was getting lower and lower. These results lend support to WM theory and have pedagogical implications for the instruction of L2 reading.
A Cognitive Study on Politeness Intention Processing and Its Association with Pragmatic Failure in Cross-Cultural Communication
Authors: Yan Rong , Feng Tengfei , Zare Samad
Published: September 2024

Although a large number of studies have focused on various aspects of politeness, very little is known about how politeness intention is activated cognitively during verbal communication. The present study aims to explore the cognitive mechanism of politeness intention processing, and how it is related to pragmatic failure during cross-cultural communication. Using 30 Chinese EFL university students who were instructed to finish a probe word judgment task with 96 virtual scenarios, the results indicate that within both mono- and cross-cultural contexts, the response time in the experimental scenarios was significantly slower than that of the filler scenarios. This suggests that politeness intention was activated while understanding the surface meaning of the conversation; however, the EFL learners could not completely avoid the negative transfer of their native politeness conventions when they were comprehending the conversational intention of the target language. Furthermore, no significant differences in response time were found between the groups with high and low English pragmatic competence, illustrating that transferring the pragmatic rules and principles into cross-cultural communication skills was more cognitively demanding. Overall, this study adds to the literature on politeness research and provides some implications for foreign language pragmatic instructions.
Systematizing Teacher Development: A Review of Foreign Language Teacher Learning
Authors: Zeng Guang
Published: September 2024

Foreign language teaching practice is developing rapidly, but research on foreign language teacher learning is currently relatively fragmented and unstructured. The book Foreign Language Teacher Learning, written by Professor Kang Yan from Capital Normal University, published in September 2022, makes a systematic introduction to foreign language teacher learning, which to some extent makes up for this shortcoming. Her book presents the lineage of foreign language teacher learning research at home and abroad, analyzes both theoretical and practical aspects, reviews the cuttingedge research results, and foresees the future development trend, painting a complete research picture for researchers in the field of foreign language teaching and teacher education as well as front-line teachers interested in foreign language teacher learning. This is an important inspiration for conducting foreign language teacher learning research in the future. And this paper makes a review of the book from aspects such as its content, major characteristics, contributions and limitations.
How does using an AR learning environment affect student learning of a radical substitution mechanism?
Authors: Bullock Martin , Huwer Johannes , Graulich Nicole
Published: September 2024

As the use of augmented reality (AR) in educational settings grows, it becomes increasingly important to understand how to use AR in classrooms. Here, we present an AR learning environment that we designed for teaching an organic chemistry reaction mechanism in high school chemistry classes. This new environment was tested in six tenth-grade chemistry classes (upper secondary) taught by five different teachers in three different schools over the course of five months and evaluated for effectiveness. Students completed knowledge tests before and after they used the AR learning environment to test their learning gain, and surveys to measure their acceptance of the technology, the cognitive load they experienced, and their attitude toward the use of AR to learn the mechanism for radical substitution. Analysis shows that the knowledge posttest scores were significantly higher than the pretest scores (p < 0.001), with a large effect size (r = 0.8). Student responses showed acceptance of the technology, experience of low extraneous cognitive load, and a positive attitude toward the use of AR to learn this reaction mechanism. These findings indicate that this AR learning environment can be used to teach the mechanism of radical substitution to tenth-grade students in introductory high school chemistry courses.
Vitamin D assay and supplementation: still debatable issues
Authors: Plebani Mario , Zaninotto Martina , Giannini Sandro , Sella Stefania , Fusaro Maria , Tripepi Giovanni , Gallieni Maurizio , Herrmann Markus , Cozzolino Mario
Published: September 2024

Over the last decades, in addition to the improvement of pathophysiological knowledge regarding the role and mechanisms of action of vitamin D, there has been a progressive advancement in analytical technologies for its measurement, as well as in methodological standardization. A significant number of scientific works, meta-analyses, and guidelines have been published on the importance of vitamin D and the need for supplementation in deficient individuals. However, it appears necessary to clarify the fundamental elements related to the measurement of vitamin D (both at the strictly analytical and post-analytical levels) and the scientific evidence related to the efficacy/safety of supplementation. In particular, there is a need to discuss current recommended levels for deficiency, insufficiency and possible toxicity in the light of evidence from standardization projects. Additionally, given the important interrelations between vitamin D, parathyroid hormone (PTH), and fibroblast growth factor-23 (FGF23), the analytical issues and clinical utility of these biomarkers will be discussed.
Spectrally efficient DWDM system using DQPSK modulation
Authors: Prakash Deepthi , Managuli Manjunath
Published: September 2024

DWDM technology is gaining popularity in fiber-optic communication due to high-speed transmission channel capacity demands. The adoption of this system has been driven by this demand. Researchers focus on optimizing data transmission parameters within channel characteristics for maximum performance. The signal’s form typically influences the optical channel capacity, the guiding medium’s dispersive and non-linear characteristics, and interference from multiple sources. This study investigates how efficient modulated systems control linear and non-linear impairments in optical channel capacity due to high data rates transmitted over optical communication networks, aiming to circumvent current issues. The selection of pulse shape and modulation format is crucial for an effective DWDM optical communication system due to the rigorous specifications of the optical channel. Modulation formats like intensity and phase have become viable network design technologies, allowing for network creation that operates to the designer’s satisfaction. This academic study examines the theoretical properties of various models used to analyze and recreate high-speed optical communication links, aiming to understand the impact of system components and modulation techniques.
Estrogen-insensitivity syndrome (EIS) in a female adolescent patient – a case report
Authors: Soltani Akbar , Fatollahzadeh Mahdieh , Izadi Pantea , Rad Zahra Abbaspour , Tavassol Zahra Hoseini , Pajavand Hamid , Amini Masoomeh , Hasani-Ranjbar Shirin
Published: September 2024

Objectives

Estrogen insensitivity syndrome (EIS) is a rare genetic disorder characterized by an autosomal dominant inheritance pattern. The disease results from a pathogenic variant in the ESR1 (estrogen receptor 1) gene, leading to estrogen resistance in individuals possessing the 46, XX karyotype. The alpha receptor, which is predominant in peripheral tissues, is responsible for estrogen action. As a result, pathogenic variants in the ESR1 gene can cause various disorders, such as changes in secondary sexual characteristics, increased concentrations of estrogen and gonadotropins, and delayed bone maturation.

Case presentation

Here, the case of a 13-year-old girl, with high estrogen and gonadotropin concentrations, lack of breast development, uterine growth and delayed bone age is described. The patient’s parents were related. She was found to have a homozygous pathogenic variant in the ESR1 gene located on chromosome 6q25, which interferes with estrogen signaling.

Conclusions

This case supports that disruption of ESR1 causes profound estrogen resistance in females.
Mineralocorticoid receptor antagonist monotherapy in pediatric non-classical 11β-hydroxylase deficiency
Authors: Kennedy Elaine C. , Stack Maria , Carolan Eirin , Durkan Maeve , Joyce Caroline M. , Hawkes Colin P.
Published: September 2024

Objectives

Congenital adrenal hyperplasia (CAH) is an uncommon genetic disorder which affects cortisol production in the adrenal glands. It is usually treated with glucocorticoids. We present a case of non-classical CAH caused by the partial deficiency of 11 beta-hydroxylase (11βOH) which was treated with aldosterone antagonist (eplerenone) monotherapy.

Case presentation

An adolescent male was diagnosed with 11 beta-hydroxylase deficiency (11βOHD) at 13 years of age when he presented with hypertension, fatigue and headaches. He was initially treated with glucocorticoids, but requested an alternative therapy. Eplerenone was commenced at 25 mg with subsequent dose increases to 100 mg daily. His hypertension was controlled on this regimen, achieving a 24 h average blood pressure of 124/81 mmHg.

Conclusions

CAH caused by 11βOHD is a known cause of hypertension. It is usually managed with glucocorticoids, and antihypertensives are added if blood pressure remains uncontrolled. In this case, glucocorticoid therapy was not tolerated and treatment with aldosterone antagonist monotherapy was effective in controlling his hypertension.
Thermoluminescence response of Ce doped CaTiO3 nanophosphor synthesized by hydrothermal method for gamma dosimetry
Authors: Hussain Taqmeem , Kousar Rahila , Younas Kanwal , Saleem Khurram , Shahzad Aamir , Munir Tariq , Fakhar-e-Alam Muhammad , Mehmood Arsalan , Asif Muhammad , Dahlous Kholood A. , Shibl Mohamed F. , Al-Qahtani Noora H.
Published: September 2024

Nanocrystalline calcium titanate (CaTiO3) doped with cerium ions (0.02 mol%) was synthesized via hydrothermal method and its luminescent properties were studied for gamma dosimetry. For the synthesized samples, the best luminescent response was achieved after annealing at 700 °C for 8 h. The synthesis was confirmed via XRD technique yielding the cyrstallite size of 22 nm for the most intense peak (121). The surface morphology was studied via scanning electron microscopy (SEM) yielding the grain size of 12 µm. The strong IR absorptions appeared at 700 cm−1 and 712 cm−1 attributed to bending mode of vibrations changing angle between Ti–O–Ti for CaTiO3 and CaTiO3:Ce respectively, as confirmed via Fourier-Transform Infrared (FTIR) Spectroscopy. Thermoluminescent (TL) response of undoped and doped samples was studied by Mikrolab RA94 TLD Reader-Analyzer having heating rate 10 °C/s, for absorbed doses 0–20 mGy from 137Cs γ-source having a dose rate 100 mSv/h. The found values at 662 keV for the photon-sensing parameters, i.e., mass attenuation coefficients (μ/ρ), mass-energy attenuation coefficient (μ
en/ρ), effective atomic number for photon interaction (Z
eff,PI) and effective atomic number for total photon energy absorption (Z
eff,PEA) were 0.07030882 cm2/g, 0.0280245 cm2/g, 13.9 and 13.4 respectively. Thus, synthesized nanophosphor has shown excellent thermoluminescent dosimetric response for gamma radiation sensing in the selected dose range.
From the Editors
Authors: Kugelmann Robert , Milburn Milo
Published: September 2024

With this issue, Integratus is in the middle of its second year. Submissions are on the increase, with a wide variety of manuscripts coming our way. This issue represents some of the distinct ways the journal defines itself. No one type of article represents them all. At the same time, Integratus is true to its mission to be a Catholic perspective on psychotherapy and mental health. There is, both because of the types of articles that we seek, and because of the Catholic character of the journal, much interdisciplinary work being done in the journal.
“But who do you say that I am?” Affectus Fidei and Bonds of Trust in Psychoanalytic Practice
Authors: Bowen Enika Cocoli
Published: September 2024

Affective bonds that span our lives rest on a foundation of credibility and truth. This study proposes an introductory description of theological and psychoanalytic elements that build a conceptual model resting on the fundamental truths of Christian faith. Theological elements are used to form a floor whereon psychotherapeutic work can rest and build the path that runs from the awareness of symptoms and asking for help to the attainment of enduring and authentic happiness. Affectus fidei (the affection of faith) emerges as the central theological concept that ties together the existential-relational elements of human life as observed in the here-and-now of therapeutic work, toward the development of confidence and self-understanding that leads toward growth and health. The here-and-now of therapeutic attainments depends on the symbolic space that opens between past and future, the real and the imaginary, the desired and the unhoped for. Without a foundation of credibility and truth, the symbolic activity of therapy that aims at a more mature look at one's life cannot emerge. When the affective space of therapy is recognized as credible, the symbolic dimension emerges and the work of therapy flourishes. Only then do the members of the therapeutic couple surrender confidently to the persuasive affective bond that rests on the credibility of the good.
Narration of the Experience of Emotional Deprivation Disorder and Affirmation Therapy
Authors: Lieser Carol S.
Published: September 2024

Psychiatrists Anna Terruwe and Conrad Baars wrote of emotional deprivation disorder (EDD) and identified the challenges of the disorder. This article presents the specifics of what one individual with EDD experienced and how affirmation therapy (AT) was helpful. The patient is an educated, professional, middle-aged woman who shares her experiences of woundedness and healing, which helps her to make sense of her life experiences. A discussion of some events that led to the manifestation of EDD in her life, how it affected the fullness and quality of her life, especially without appropriate therapy, and a brief overview of affirmation therapy as perceived by the patient are presented. Following the major narratives of her life experiences and her therapy, a brief exploratory analysis of the content and context of her narration is provided. Her story provides excellent insight to those of us in the mental health field about what caused EDD in this patient's life and how affirmation therapy helped her to heal the wounds that caused her to develop EDD and to develop the fuller quality of life that she now enjoys.
El camino hacia la regulación internacional del trabajo mediante plataformas digitales offline: una propuesta normativa
Authors: Rosenbaum Carli Federico
Published: September 2024

El texto analiza la propuesta de un marco regulatorio internacional del trabajo mediante plataformas digitales offline. Se pretende explorar la creciente relevancia de este tipo de empleo en la economía actual y la necesidad de mecanismos regulatorios que garanticen condiciones laborales decentes y justas. El texto se divide en tres partes. En la primera parte, se revisa las características del trabajo en la economía de plataformas, los desafíos inherentes a este tipo de empleo y las razones que justifican una intervención regulatoria. En la segunda parte, se analizan varios modelos de regulación y legislación existentes y propuestos que apuntan a abordar el problema del trabajo mediante plataformas. En la tercera parte, se propone un marco regulatorio internacional específico para plataformas digitales offline que promueva un trabajo decente y justo. El texto también analiza el papel de la Organización Internacional del Trabajo (OIT) en relación con este tema y el potencial de regulación internacional del trabajo mediante plataformas digitales.
Synthesis and Physicochemical Properties of ((9H-(4,5-Diazafluoren)-9-ylidene)methyl)arylenes
Authors: ЧЕШКИНА Д.С. , БЕККЕР К.С. , СОНИНА А.А. , КАЗАНЦЕВ М.С.
Published: September 2024

Представлен синтез ((9H-(4,5-диазафлуорен)-9-илиден)метил)ариленов и изучены их физико-химические характеристики методами циклической вольтамперометрии и оптической спектроскопии. Целевые соединения получены из коммерчески доступных реагентов в три стадии с использованием комбинации реакций кросс-сочетания Сузуки–Мияуры и конденсации. Установлено, что соединения обладают низким квантовым выходом фотолюминесценции в растворе, а 9-(4-([2,2-битиофен]-5-ил)фенилилиден)-9H-4,5-диазафлуорен (DPTT) обладает эффектом усиления люминесценции в агрегированном состоянии. Методом рентгеноструктурного анализа установлена кристаллическая структура DPTT. Монокристаллы данного соединения имеют морфологию вытянутых пластин и обладают фотолюминесценцией с квантовым выходом 5 %.

The synthesis of ((9H-(4,5-diazafluorene)-9-ylidene)methyl)arylenes is presented and their physicochemical characteristics are studied by cyclic voltammetry and optical spectroscopy. The target compounds were synthesised from commercially available reagents in three steps using a combination of Suzuki–Miyaura cross-coupling and condensation reactions. It was found that the compounds had a low photoluminescence quantum yield in solution, and 9-(4-([2,2'-bithiophen]-5-yl)phenylidene)-9H-4,5-diazafluorene demonstrates aggregation-induced luminescence. The crystal structure of 9-(4-([2,2'-bithiophen]-5-yl)phenylidene)-9H-4,5-diazafluorene was solved by X-ray diffraction analysis. The single crystals of this compound have the elongated plate morphology and exhibit photoluminescence quantum yield of 5 %.
GROUND TEMPERATURE AT THE DEPTH OF ZERO ANNUAL AMPLITUDE IN THE AREA OF SUPRAPERMAFROST TALIKS IN CENTRAL YAKUTIA
Authors: ЛЕБЕДЕВА Л.С. , БАИШЕВ Н.Е. , ПАВЛОВА Н.А. , ЕФРЕМОВ В.С. , ОГОНЕРОВ В.В. , ТАРБЕЕВА А.М.
Published: September 2024

Несмотря на низкие средние годовые температуры воздуха и малое количество атмосферных осадков, в некоторых условиях сплошной криолитозоны Центральной Якутии существуют субаэральные надмерзлотные водоносные талики. В статье приводится анализ сезонной и межгодовой динамики температуры пород в контрастных геокриологических условиях - на участках распространения мерзлоты с поверхности и надмерзлотных субаэральных таликов на ключевом участке Левая Шестаковка, расположенном в 20 км юго-западнее г. Якутска. Кровля многолетней мерзлоты на участке залегает на глубинах от 0.5 до 20 м. Самые высокие температуры пород характерны для площади распространения водоносных надмерзлотных таликов, приуроченных к пологим склонам, которые сложены песчаными отложениями и покрыты редким сосновым лесом. Мощность сезонномерзлого слоя достигает 3 м, а глубина нулевых годовых амплитуд варьирует от 6 до 12 м. Талые породы сохраняются за счет постоянной фильтрации подземных вод в них. Самая низкая температура пород характерна для маревого участка и поймы реки. Глубина сезонного протаивания изменяется от 0.5 до 1.0 м, глубина нулевых годовых амплитуд превышает 15 м. В последние годы отмечено медленное промерзание таликов снизу за счет слабовыраженного охлаждения толщи, подстилающей талые водоносные породы. За пределами развития таликов зафиксированы слабые разнонаправленные изменения температуры пород.

Despite the low mean annual air temperature and low precipitation, subaerial suprapermafrost aquifer taliks are formed in some cases in the continuous permafrost zone of Central Yakutia. The paper presents an analysis of the seasonal and interannual dynamics of ground temperature in contrasting geocryological conditions - in areas of permafrost spread from the surface and in suprapermafrost subaerial taliks - of the key area of Levaya Shestakovka 20 km southwest of Yakutsk. The permafrost table in this area a occurs at depths from 0.5 to 20 m. The highest ground temperatures are typical of the area of aquiferous suprapermafrost taliks confined to gentle slopes composed of sandy sediments and covered with pine woodland. The thickness of the seasonally frozen layer reaches 3 m, and the depth of zero annual amplitudes varies from 6 to 12 m. Thawed deposits are preserved due to the continuous filtration of groundwater in them. The lowest ground temperatures are characteristic of the mire and the river floodplain. The depth of seasonal thawing varies from 0.5 to 1.0 m, and the depth of zero annual amplitudes exceeds 15 m. In recent years, slow freezing of the taliks from below has been noted due to mild cooling of the strata underlying the thawed aquifers. Beyond the area of taliks, weak multidirectional changes in ground temperature have been recorded.
COMPARATIVE ANALYSIS OF AREA DISTRIBUTIONS FOR THERMOKARST LAKES WITHIN DIFFERENT TYPES OF THE SURFACE OF THERMOKARST PLAINS WITH FLUVIAL EROSION
Authors: ВИКТОРОВ А.С. , КАПРАЛОВА В.Н. , ОРЛОВ Т.В.
Published: September 2024

Проведен сравнительный анализ статистических распределений площадей термокарстовых озер в пределах различных генетических типов поверхностей эрозионно-термокарстовых равнин - участков, расположенных на волнистых междуречьях, и участков пониженных поверхностей, занятых хасыреями (аласами), нередко образующими слившиеся массивы. С использованием количественных критериев и космических снимков на материале восьми участков, находящихся в разных физико-географических условиях (Ямал, Тазовский полуостров, Колымская низменность, долина Пенжины), установлено существование статистически значимых различий распределений площадей термокарстовых озер в пределах разных генетических типов поверхностей. На основе статистического анализа показано, что распределение площадей термокарстовых озер является интегрально-экспоненциальным. Это позволяет сделать вывод, что на каждом из двух типов поверхности в пределах эрозионно-термокарстовых равнин устанавливается динамическое равновесие в процессах возникновения, роста и спуска термокарстовых озер. При существенных различиях наблюдается коррелированность значений параметров распределений площадей термокарстовых озер на основной водораздельной поверхности эрозионно-термокарстовых равнин и площадей вторичных озер в хасыреях.

Thermokarst plains with fluvial erosion include two genetically different types of surface: slightly undulating watersheds and lowered surfaces of khasyreys (drained thermokarst lakes with secondary thermokarst lakes). The research deals with a comparative analysis of statistical distributions of the areas of thermokarst lakes and secondary lakes. Using statistical criteria and remote sensing data for eight key sites in different natural conditions, such as Yamal and Taz peninsulas, the Kolyma Lowland, and the Penzhina River valley, we determined statistically significant differences in the area distributions of thermokarst lakes within different genetic types of the surface. Statistical analysis shows that the areas of thermokarst lakes correspond to an integral-exponential distribution. This allows us to conclude that a dynamic equilibrium is established within each type of the surface in the course of the initiation, growth, and drainage of thermokarst lakes. Though the parameters of thermokarst lakes differ significantly, we find a correlation between the distribution parameters of lake areas within the main surface of thermokarst plains with fluvial erosion and the surface of khasyreys with secondary lakes.
EROSIONAL PROCESSES IN SMALL TUNDRA CATCHMENTS IN THE NORTH OF YAKUTIA
Authors: ТАРБЕЕВА А.М. , ЕФРЕМОВ В.С. , ЛЕБЕДЕВА Л.С. , ШАМОВ В.В.
Published: September 2024

Эрозионные процессы играют важную роль в выносе продуктов разрушения мерзлых пород. С целью выявления темпов и механизмов эрозионных процессов в условиях деградации мерзлых пород были типизированы формы флювиального рельефа малых водосборов в предгорьях Хараулахского хребта, охарактеризована их морфология, условия образования и динамика за 2019-2022 гг. Наиболее динамичны формы рельефа, связанные с вытаиванием жильных льдов: термокарстовые ложбины стока, рытвины и эрозионно-термокарстовые овраги. Термоэрозионные овраги, формирующиеся в отложениях без жильных льдов, растут при аномально высоких паводках, а в остальное время их борта медленно оползают под действием снежников. В верховьях малых рек происходит аккумуляция наносов, вынесенных из оврагов и рытвин. Русла рек и ручьев начальных порядков стабильны, что характерно и для других районов криолитозоны. Различия в динамике разных типов эрозионных форм можно объяснить усилением теплового, а не механического воздействия водных потоков на мерзлые отложения, которое наблюдается в условиях повышения температур воздуха при стабильном количестве осадков на севере Якутии.

Erosion plays an important role in removing permafrost degradation products. In order to identify the rates and mechanisms of erosion in degrading permafrost, fluvial landforms in small catchments at the foothills of the Kharaulakh Range were typified, and their morphology, formation conditions, and dynamics for 2019-2022 were characterized. The most dynamic landforms associated with melting ice wedges were thermokarst runoff troughs (water tracks), rills, and thermoerosional gullies. Thermoerosional gullies forming in sediments without wedged ice grow upon very high floods; in the rest of the time, their sides slowly slide down under the action of snowfields. Sediments from gullies and rills are deposited in the upper reaches of small rivers. The channels of small rivers are relatively stable, which is also typical of other permafrost regions. Differences in the dynamics of erosional landforms can be explained by an increase in the thermal rather than mechanical impact of water on frozen deposits, which is observed with the rise in air temperature against the background of relatively stable precipitation in the north of Yakutia.