bluuebunny/crossref_metadata_2025 huggingface dataset:
Modification Technique Influence on the Adsorption Capability of Organobentonites for Reactive and Direct Dyes
Authors: Morsümbül Seniha , Akçakoca Kumbasar Emriye Perrin , Yapar Saadet
Published: June 2024

In this study, the adsorption of reactive and direct dyes from synthetic textile wastewater using organobentonites modified by two different routes was studied. Except for the drying step, the synthesis conditions were the same, and organobentonites were synthesized by employing a cationic surfactant at a level corresponding to the entire cation exchange capacity of bentonite under microwave irradiation. In the final step, the samples were dried using either a freeze dryer or an air dryer. The structural characteristics of the organobentonites were determined via XRD and FTIR analyses. The obtained equilibrium data indicated that the adsorption process fitted to the Langmuir isotherm model for both dyes. Although the results indicated that both organobentonites adsorbed two of the dyes, the freeze-dried sample could serve as a more effective adsorbent for removing reactive and direct dyes from wastewater.
Detection of Lung Cancer Cells Using Deep Learning Methods
Authors: Genç Muhittin , Akar Funda
Published: June 2024

Lung cancer stands out as a high mortality, fatal disease worldwide. Early diagnosis is crucial for effective treatment of this disease; however, treatment options can be limited when it is often diagnosed in advanced stages. This study examines the role of artificial intelligence (AI) techniques in early diagnosis of lung cancer and emphasizes the advantages it provides. Particularly, the ability of deep learning algorithms to extract meaningful features from complex datasets indicates significant potential for detecting early stages of lung cancer. In this context, it is anticipated that AI-supported diagnostic systems have the potential to significantly improve lung cancer diagnostic methods by reducing the workload of radiologists and increasing accuracy rates. In this study, a total of 6 datasets were obtained by applying Gabor filter and Histogram Equalization+CLAHE filter to original datasets. The results obtained in the diagnosis of lung cancer using Convolutional Neural Networks (CNN) and YOLO algorithms are evaluated in two different categories. One of these categories is the investigation of the effect of image preprocessing methods. The other is the investigation of the effect of dataset partitioning into training, testing, and validation on success. According to the results obtained, the highest success rate in terms of F1 Score for the CNN model was achieved in both dataset partitioning (70%-20%-10% and 60%-20%-20%) with the datasets subjected to Histogram Equalization+CLAHE filter. It was obtained as 99%. For the YOLO model, the highest success rate was determined as 96% F1 Score with the same preprocessing technique and dataset partition. The effect of image preprocessing and dataset partitioning on success is not as high in the YOLO model as it is in the CNN model.
Quantum Chemical Computations, Molecular Docking, and ADMET Predictions of Cynarin
Authors: Çağlar Yavuz Sevtap
Published: June 2024

Cynarin (1,3-o-dicaffeoylquinic acid) is one of the biologically active functional food components which is the most well-known caffeoylquinic acid derivative found in artichoke. The structural and electronic features of cynarin compound were investigated theoretically using density functional theory (DFT). The highest occupied molecular orbital (HOMO) and the least occupied molecular orbital (LUMO) are the most significant orbitals in molecules, these orbitals are quite helpful to know several molecular features such as the chemical reactivity, kinetic stability, electronegativity, chemical potential, electrophilicity index, chemical hardness and softness and electronegativity. Molecular orbital analysis HOMO-LUMO was used to explore the stability of the molecule. Moreover, physicochemical properties, drug-likeness, and toxicity estimation of the cynarin compound were appraised owing to ADMET (including absorption, distribution, metabolism, excretion, and toxicology). Molecular docking was carried out to examine the biological activity of the cynarin compound. 5A19, a liver cancer biomarker, is human methionine adenosyl-transferase enzymes. Cynarin-methionine adenosyl-transferase enzyme binding energy value was calculated as -7.9 kcal/mol. As a result, this in silico study confirmed that cynarin has the potential to be a drug by revealing its protective effect against liver diseases.
Bayesian Parameter Estimation for Geometric Process with Rayleigh Distribution
Authors: Yılmaz Asuman
Published: June 2024

The main purpose of this study is to deal with the parameter estimation problem for the geometric process (GP) when the distribution of the first occurrence time of an event is assumed to be Rayleigh. For this purpose, maximum likelihood and Bayesian parameter estimation methods are discussed. Lindley and MCMC approximation methods are used in Bayesian calculations. Additionally, a novel method called the Modified-Lindley approximation has been proposed as an alternative to the Lindley approximation. An extensive simulation study was conducted to compare the performances of the prediction methods. Finally, a real data set is analyzed for illustrative purposes.
Assessing the Impact of Brand Loyalty on Tobac-co Purchasing Decisions and Spending Patterns
Authors: Sachani Dipakkumar Kanubhai
Published: June 2024

This study examines how brand loyalty affects tobacco industry expenditure patterns and purchase decisions. The study's primary aims were to investigate the impact of brand loyalty on customer behavior, appraise the efficacy of tobacco corporations' marketing tactics, and analyze the consequences for public health and consumer welfare. A review process based on secondary data was utilized, combining empirical evidence from government publications, industry reports, and academic journals. Important discoveries show that brand loyalty significantly influences tobacco purchase decisions, customer preferences, and spending habits. Advertising, promotions, and sponsorships are marketing tactics vital in building brand loyalty and influencing consumer behavior. Brand loyalty questions its implications for consumer welfare and public health outcomes to counteract the negative consequences. As a result, evidence-based policies and regulatory measures are required. The significance of comprehensive tobacco control measures, regulatory interventions, and public health initiatives in promoting better choices and addressing public health concerns related to tobacco smoking is highlighted by the policy implications.
Estudos sobre a organização e representação da informação em um contexto museológico.
Authors: De Paula Josefa , Leite da Silva Eva Cristina
Published: June 2024

The registration of information today has been one of the biggest challenges, as the information mass increases over time. To use these information records, it must be recoverable. The need to organize information for later retrieval has been the subject of studies, which make possible dialogues between fields of knowledge that have information as an instrument, namely, Museology and Information Science; The present work presents a bibliographical survey about studies of the Organization of Information (OI) and Representation of Information (IR) in a museological context, with the objective of deepening the understanding of this theme both OI and IR in these spaces; To this end, it adopted Bardin's Content Analysis methodology, developed in the search for a set of Databases that constitute the largest indexers of scientific content on the theme of this work; Dealing with a possible dialogue between the Organization and Representation of Information in Museums, shows the concern to explore a subject that is not very expressive in the databases of events and research, if related to other more recurring themes .; The dialogue between the OC and IR for access to information in museological institutions, facilitates both access to information for the public who accesses these places, as well as for professionals who have direct contact with museological documentation. Furthermore, it supports the development of practices by professionals working in the field of Museology, Information Science and the like, through the dissemination of information.
Análise da produção do conhecimento das Ciências Sociais Aplicadas na Iniciação Científica
Authors: Pereira Batista Andreza , Belmont de Farias Gabriela
Published: June 2024

Higher education institutions have among their basic functions the scientific production arising from the various activities performed by it, such as through the scholarships for scientific initiation, so that one way to measure and highlight the constitution of knowledge is the mapping of these publications. This article aims to analyze the scientific production of the projects of the Programa Institucional de Bolsas de Iniciação Científica of the Federal University of Ceará, as well as to understand which means of communication are being adopted by the program's researchers. This is an exploratory, descriptive and documental research, with a quantiqualitative approach and has as method the case study. It uses as a data collection instrument the scientific initiation reports, mapping those with and without productions and their different typologies, and has as a cutout the areas of knowledge linked to the Applied Social Sciences. It statistically analyzes the collected data, based on theoretical propositions associated with the search for the Qualis of the publications on the Plataforma Sucupira of the Coordination of Superior Level Staff Improvement. The results show the existence of scientific productions arising from scientific initiation projects and indicate that it is used predominantly articles in journals and annals of events for the dissemination of studies. It concludes that the mapping of the scientific productions of these projects can be representative of what has been produced at the university, making it possible to meet the institutional demands, of science and society, and, therefore, to contribute to the training of the scientific initiation scholarship student, one of the main objectives of the program.
Identificação de Vítimas de Desastre no Contexto da Ciência da Informação
Authors: Gonçalves Teixeira Rodrigo , Luiz Pinto Adilson
Published: June 2024

Disasters are topics of great sociological interest for several reasons, including the deaths that eventually occur and the serious damage caused. In disasters with multiple fatalities, forensic identification is essential for humanitarian, civil and criminal reasons. This identification process is internationally called Disaster Victim Identification (DVI). The DVI process dynamics requires protocol adoption aiming to minimize the damages resulting from the event and to maximize the available resources to accomplish the mission successfully. In this vein, it’s imperative the definition of an effective communication structure that ensures critical information is transmitted to recipients. Objects of Information Science study are present in all activities developed in a DVI response, from the origin of information to its retrieval and use. The objective of this article is to demonstrate some aspects of Information Science in the DVI response, for this in the first section there is an introduction aiming to offer a first contact with the proposed theme, followed by a section with a literature review on DVI. The third section seeks to present the relationship and some aspects of Information Science in the DVI activity. In the fourth section, the dynamics of the activities are presented in a real case: the DVI response on the occasion of the rupture of the Brumadinho dam. The fifth and last section presents the final considerations.
Publicações científicas brasileiras em Ciência da Informação no Brasil indexadas na Web of Science
Authors: Pastana Neves João Paulo , Lopes dos Santos Júnior Roberto
Published: June 2024

Nos 50 anos de história da Ciência da Informação no Basil, bastantes pesquisas foram realizadas para o escopo da informação científica que é a sua gênese, contribuir para o avanço científico é sua jornada no hall da ciência. O objetivo do artigo foi analisar a produção cientifica da CI no Brasil dos seus 50 anos de história na Web of Science (WoS), por meio da abordagem quantitativa e qualitativa, e teve como método a análise bibliométrica. Após a coletas dos dados, a análise ocorreu mediante a utilização dos softwares VOSvierwer e Gephi, foram recuperadas 207 publicações cientificas desde o ano de 1971 até o ano 2021, dos quais são artigos científicos (original, revisão e anais).  As publicações envolveram 416 autores, 23 países, 142 instituições, 46 periódicos e 708 palavras-chave, sendo que 87,27% das publicações se concentram nos últimos 11 (onze) anos. O periódico Informação Sociedade Estudos foi a revista científica que mais publicou documentos científicos, com 39 do total. Além disso, pesquisadores Bufrem (UNESP) e Martinez-Ávila (ULE-ESP/UNESP) e as instituições UNESP e UFMG foram os que mais produziram publicações científicas. Em relação à colaboração internacional, 12,72% dos trabalhos foram produzidos em parceria com diversas instituições no mundo, obtendo como destaque Europa, com 71,46%.
Correlações da Teoria da Representação e Teoria da Intencionalidade:
Authors: Alves Sanchez Fernanda , Ferreira de Castro Fabiano , Luiz Vechiato Fernando , Aparecida Borsetti Gregorio Vidotti Silvana
Published: June 2024

The Theory of Representation and the Theory of Intentionality are concepts arising from areas of knowledge such as Psychology, Philosophy and Cognitive Sciences. In the field of Information Science, Information Representation is an already consolidated concept, however, there are few works on the Theory of Intentionality. In view of the post-custodial paradigm, it is possible to affirm that informational subjects are active individuals in the socio-informative scenario, who apply their intention to produce, organize, represent and search for information in different types of digital informational environments. As an objective, the research sought to identify the existing correlations between the theories of Representation and Intentionality in the context of Information Science, aiming to verify which contributions to the Findability of Information - a concept whose approach includes theoretical-practical perspectives for projects, implementations and evaluations of informational environments. This is research that presents itself as bibliographical and exploratory and with a qualitative approach in databases such as Portal in Periodicals of Capes, the Database on Information Science (BRAPCI) and Google Scholar. Among the research results, it was possible to identify correlations in the concepts of Representation Theory and Intentionality, as well as the importance of the foundations of these concepts to enhance the Findability of Information. Finally, it is concluded that there is a need to deepen studies on Intentionality in ​​Information Science, given the scarcity of research, in addition to its relevance in bringing the positioning of the informational subject within the concept of Information Findability.
CIERDI: método para la inspección ergonómica de repositorios digitales institucionales
Authors: Honorio dos Santos Wilma , Gamez Luciano , Mancini Felipe
Published: June 2024

Contextualización: Los repositorios digitales son entornos de información para gestionar y controlar la producción científica y académica de instituciones y/o comunidades. Vacío: Sin embargo, pueden presentar lagunas como fallas de navegación, baja usabilidad y accesibilidad, búsquedas limitadas, poca divulgación del entorno y poco o ningún uso de servicios personalizados. Propósito: En este contexto, se hace necesaria una evaluación ergonómica de los repositorios digitales institucionales. Material y métodos: Se realizó una revisión integradora de la literatura para evaluar el estado del arte de las técnicas de usabilidad aplicadas a la ergonomía de los repositorios digitales institucionales y para apoyar los métodos aplicados en este trabajo; el fichaje de los artículos incluidos ayudó en la elección del método de evaluación de usabilidad y en la selección de un conjunto de requisitos para la inspección de usabilidad en los repositorios digitales institucionales. Resultados: Propuesta de una lista de verificación con especificaciones y recomendaciones ergonómicas para evaluar la usabilidad de los repositorios digitales institucionales. Consideraciones finales: La estrategia de revisión integradora de la literatura de las bases de datos utilizadas y los descriptores utilizados mostraron que las pruebas aplicadas mejoran la usabilidad de los repositorios digitales. Durante el desarrollo de este estudio se observó la inexistencia de una lista de verificación centrada en especificaciones y recomendaciones ergonómicas para evaluar la ergonomía y usabilidad de los repositorios digitales institucionales. Para llenar este vacío, se propuso una lista de verificación de inspección ergonómica para estos repositorios digitales.
Interdisciplinary relations between Information Science and Law: a study based on publications on the IBICT journal
Authors: Honorio dos Santos Wilma , Gamez Luciano , Mancini Felipe
Published: June 2024

The present work aims to analyze themes, addressed in the area of ​​Information Science, which are correlated with the area of ​​Law. It is characterized, in terms of its approach, in qualitative and quantitative research. As for its objectives, it is characterized as exploratory field research, using an exploratory-descriptive procedure. To read and characterize the data, Social Network Analysis (ARS) is used. The results indicate that the works in the area of ​​Information Science that maintain a thematic relationship with the area of ​​Law, in the sample analyzed in this article, have more frequently addressed aspects related to "Copyright", "Ethics", "Internet", “Intellectual Property” and “Open Access”. Finally, there is evidence of the potential of Information Science, as a field of knowledge, in maintaining interdisciplinary relationships with Law.
Análisis de la producción de conocimiento en Ciencias Sociales Aplicadas en la Iniciación Científica
Authors: Pereira Batista Andreza , Belmont de Farias Gabriela
Published: June 2024

Higher education institutions play a vital role in generating scientific knowledge through programs like scientific initiation scholarships. Mapping the publications produced through these programs is a key method for assessing and highlighting the development of knowledge. This study examines the scientific outputs of . This article aims to analyze the scientific output of the Programa Institucional de Bolsas de Iniciação Científica (PIBIC) of the Federal University of Ceará
Digital transformation in the public sphere: a bibliometric analysis
Authors: Amadeu Dutra Moresi Eduardo , Aparecido da Silva Alves Wanderson , Bernardi da Silva Ana Paula , Cristina Hedler Helga
Published: June 2024

This study addresses the significant impact of technology on the growth and prominence of contemporary organizations, examining the relationship between digital transformation and business sustainability. The research highlights the importance of digital adaptations to maintain relevance in the global market. The main focus is on conducting a bibliometric analysis of digital transformation, identifying emerging themes that contribute to the valorization of organizations. The adopted methodology consists of a literature review, using the Scopus database and tools such as VOSviewer and Gephi for network analysis of keyword co-occurrence, co-citation of cited references, bibliographic coupling of documents, and identification of emerging trends. Additionally, content analysis is employed for a more detailed examination of the identified themes. The results indicate that the effectiveness of digital transformation in an organization is intrinsically linked to its level of maturity in electronic governance. Furthermore, it is evident that the adoption of an IT governance framework is crucial for a successful implementation of digital transformation.
Assessment of transaminase enzymes and effect of potassium iodide on its production in the yeast form of Sporothrix schenckii
Authors: Bareja Rajesh , Sumedha  , Pottathil Shinu
Published: June 2024

The dimorphic fungus () is the cause of sporotrichosis. Many fungi have transaminases, also known as aminotransferases, which are portions of proteins. However, nothing is known about this enzyme in

The current study shows how potassium iodide (KI) affects the transaminases enzymes aspartate aminotransferase (AST) and alanine aminotransferase (ALT) produced by yeast form in vitro.

YNB (yeast nitrogen base) medium was used to create a master culture of, which was then incubated at 37ºC (yeast). The amount of KI added to the YNB medium increased. Each container received one millilitre (mL) of the master culture suspension, which was then incubated at 37ºC for different lengths of time – the early-log phase on day six, the mid-log period on day twelve, and the growth peak on day eighteen, respectively. A 5% homogenate was produced after centrifugation and used in the transaminases enzyme assay.

On days 6, 12, and 18, the control specimen's mean aspartate aminotransferase level was 10.11 ± 3.09, 10.36 ± 2.33, and 17.62 ± 4.27 IU, respectively. On days 6, 12, and 18, the test specimen's mean aspartate aminotransferase level ranged from 9.80 ± 2.42 (KI 0.4 gramme %) to 19.59 ± 3.9 IU (KI 0.2 gramme %), from 4.52 ± 2.28 (KI 0.4 gramme %) to 28.46 ± 4.88 IU (KI 0.2 gramme %), and from 4.50 ± 1.02 (KI 0.8 gramme %) to 14.49 ± 3.60 IU (KI 0.05 gramme %). On days 6, 12, and 18, the control specimen's mean alanine aminotransferase level was 10.70 ± 3.82, 29.60 ± 3.02, and 19.74 ± 4.62 IU, respectively. Day 6, 12, and 18 saw variations in the test specimen's mean alanine aminotransferase level, which ranged from 11.40 ± 3.04 (KI 0.1 gramme %) to 18.52 ± 3.97 IU (KI 0.2 gramme %), 7.82 ± 1.50 (KI 0.8 gramme %) to 41.56 ± 4.56 IU (KI 0.2 gramme %), and 3.33 ± 0.70 (KI 0.8 gramme %) to 12.54 ± 1.92 IU.

The transaminase enzymes' low activity indicates that KI has an inhibiting effect on the growth of (yeast), which has caused a drop in the enzymes' activity.

The impact of KI on the lipids of may be monitored to comprehend the mechanism of action of KI in the future.
Prevalence and molecular detection of Klebsiella pneumoniae isolated from children with infectious diarrhoea in AL-Ramadi city
Authors: Al-Omar Fatima Sabri
Published: June 2024

: Infectious diarrhoea result from a wide range of bacteria, viruses and parasites. This condition is also identified as gastroenteritis, is a well-known as one of most common bacterial pathogens causing gastroenteritis. This study aims to estimate the incidence and identifying both the phenotypic and genotypic characterization of causing gastroenteritis in children under the age of five in al-Ramadi Maternity and Children Teaching Hospital.

: Stool samples were collected for 106 children suffering from gastroenteritis, Cultural and microscopical approaches were used for selection, its characteristic features were confirmed using the Vitek2 compact system, anti-microbial sensitivity test, and biofilm production test. furthermore, DNA extracted, purification and Polymerase chain reaction (PCR) were accomplished for genotypic confirmation.

In the presented research, stool samples were collected for 106 children suffering from gastroenteritis, and 100 samples were identified as source for bacterial gastroenteritis. The bacterium under consideration () has a percentage of 30%. This isolate revealed resistance to Ceftazidime (80%), nalidixic acid (33%), amikacin (36%), Azithromycin (20%), vancomycin (10%), and Imipenem (6%). Likewise, four genes in isolate were studied via PCR and the results indicates htrA, iss, Mrka and rmpA were 15 (50%), 9 (30%), 6 (20%), 0 (0%) respectively. The results of biofilm production for exposed that 3 (10%) were strong, 10 (33%) moderate, 7 (24%) weak, and 10 (33%) non-producers.

: The presented research displayed the bacterium under consideration () has a higher resistance rate to the commonly antibiotics used for bacterial gastroenteritis. In addition, (under consideration) with high resistance to antibiotics showed resistance genes in PCR, in addition to strong biofilm production.
Antimicrobial susceptibility pattern of newer beta lactam-beta lactamase inhibitor agents on the carbapenem resistant and sensitive strains of Enterobacterales and Pseudomonas aeruginosa
Authors: Jain Bhawana , Tewari Shikha , Richa Kumari , Tripathi Deepti , Dubey Dilip , Paul Saurav Sekhar
Published: June 2024

The rise of antimicrobial resistance has become a global threat in the recent years. With the rise in multidrug resistant organisms (MDRO), particularly the Carbapenem resistant organisms “difficult to treat” infections there is an urgent need for newer antibiotics. There are limited therapeutic options currently available, of which Ceftazidime avibactam (CZA) is a novel Beta lactam/ Beta lactamase inhibitor (BL/BLI) combination antibiotic. Avibactam is a non BL/BLI that binds reversibly to beta lactamase.

The study aims to find the susceptibility of the novel Beta lactam- Beta lactamase combination drugs in carbapenem resistant & carbapenem sensitive isolates.

1. To compare the susceptibility profile of CZA in Carbapenem resistant & carbapenem sensitive isolates of & ; 2. To compare the sensitivity of CZA with other group of antibiotics.

This is a retrospective observational study from January 2022 to November 2023 done in the Department of Microbiology, Medanta Hospital, Lucknow. All the bacterial culture samples received during this period were subjected to routine identification and antibiotic susceptibility test on Vitek2 compact automated system. and isolates are included in the study group.

: Of the Carbapenem Resistant isolates, , spp., spp. were 26.09% , 68.6% and 46.4% respectively. Amongst the carbapenem resistant(CR) isolates, CR (18.6%) is most susceptible to CZA than 9% CR & 3.2% CR . Of the Carbapanem sensitive isolates, sensitivity to CZA in (90.5%), (92.1%) & 87% in appeared to be much better than the other BL-BLI’s agents.

The study suggests that CZA can be used as carbapenem sparing agent only in carbapenem sensitive pathogens. Also with the rise in resistance to the novel drug, it should be used judiciously and not as empiric therapy or an alternative to carbapenems. It may be useful in NDM carbapenemase producers if used synergistically with Aztreonam.
Microbiological aspects of catheter associated urinary tract (CAUTI) infections in tertiary care hospital: A prospective cross-sectional study
Authors: Chauhan Amit Pravin , Patel Rachana , Pandya Himani , Christie Rezil , Lakhani Sucheta
Published: June 2024

Urinary Tract Infections (UTIs) rank among the most common bacterial infections, affecting all demographics in community and hospital settings. Catheterized patients in critical areas are at increased risk of Catheter-associated UTIs (CAUTIs) due to bacterial or candidial infections. This study assesses CAUTI incidence, causative agents, and antibiotic susceptibility, vital for treatment and infection control.

1. This study is aimed to find prevalence of catheter associated urinary tract infection rate among study population; 2. To find out mostly affected age group and gender; 3. The present study was taken to identify candida and bacterial uro-pathogens causing CAUTI -most common organism and their types and level of antimicrobial drug susceptibility attending a tertiary care hospital.

A three-month Prospective Cross-sectional study was conducted at Dhiraj Hospital. Following approval from the ethical committee, data collection commenced. Patients with over two days of catheterization and clinical signs of UTI were enrolled. Bacterial identification and antibiotic sensitivity were analyzed using standard protocols, alongside calculation of the CAUTI rate.

Out of 80 catheterized urine sample, 51 cases found to as CAUTI. With standard formula applied it was counted that CAUTI rate came to be 15.67%. In our study 55% men and 45% female were affected. In 45 Cases, Most common Gram Negative organisms were (37.2%), (19.6%), Pseudomonas spp (9.8%) and in 6 cases isolated. Most resistant drugs were Fluoroquinolones and Cephalosporin group. Amikacin, Fosfomycin, Meropenem and Imipenem sensitivity were 28.5%, 30%, 22.8% and 28.5% respectively. Most of candida urine infection were sensitive to azole group of antifungal.

According to micro-organism and AST pattern found in CAUTI need to formulate Antibiotic policy and strictly follow CAUTI bundle care and infection control practices which may help in line of treatment and management of patient in respective area.
Tecnologia blockchain e seu impacto nos diversos setores da administração pública brasileira
Authors: Leandro Reis Moreira de Melo Matheus , Dias Marco Antonio Harms
Published: June 2024

A tecnologia blockchain é um estilo de software descentralizado, que utiliza de operações matemáticas, com o objetivo de gerenciar e armazenar informações em blocos de dados, esses por sua vez, são interligados e permitem que as informações sejam verificadas e conferidas por quais quer usuários que tenham acesso as chaves geradas, isso torna a criptografia mais confiável, e permite que as informações, ou até mesmo documentos, não se percam com o passar do tempo, além de fornecer um espaço de armazenagem infinitamente maior que um espaço físico único, pois os dados são compartilhados e distribuídos entre todos os dispositivos que acessam esse sistema. Dessa forma, esse artigo científico em formato de revisão bibliográfica, propõe uma pesquisa a respeito do impacto que a implantação dessa tecnologia pode causar no Brasil, focando principalmente no setor público, em áreas como o armazenamento de documentos e até mesmo na luta contra a corrupção. Além disso o objetivo dessa pesquisa é gerar mais engajamento desse assunto, além de propagar a compreensão da tecnologia para cada dia mais pessoas com o intuito de ensinar de forma menos técnica como funciona e como pode desenvolver um país, além disso é importante demonstrar que é algo bem atual, porém que já é realidade em diversos setores. Alguns dos principais resultados foram que ao que os estudos indicam o Brasil não está tão a frente do assunto, e apesar de utilizar em alguns setores internamente acaba não utilizando em cooperação com a população e um dos motivos podem ser o que o uso dessa tecnologia por completa poderia causar, por exemplo a extinção de cartórios, além da diminuição da corrupção por meio do uso da certificação do blockchain. O que pode-se concluir que até que o país resolva implantar de forma mais efetiva, haverá um longo caminho a ser percorrido, enquanto outros países já fazem testes e aprovam essa tecnologia o Brasil se preocupa com adversidades que podem surgir e dessa fica tecnologicamente em desvantagem e não é visto como uma nação confiável pelo nível de corrupção, além disso perde a chance de armazenar documentos nesse software, o que economizaria em recursos econômicos e ainda poderia proteger os dados contra hackers, por meio da criptografia.
ACADEMIA DE REDE VERSUS ACADEMIA DE BAIRRO: EXPLORAÇÃO DE PROPOSTA DE VALORES
Authors: Pereira Ligia Maria , Da Silva abrahão Gabriel José , Nascimento da Silva João Paulo
Published: June 2024

Este estudo analisou as propostas de valores de duas academias, uma de rede e outra de bairro, em relação à satisfação dos clientes. Utilizando uma metodologia qualitativa, foram coletados dados dos comentários online dos clientes, e doze colaboradores das academias foram entrevistados, incluindo clientes, instrutores e gerentes. Três categorias foram criadas com base nos principais itens mencionados pelos clientes, alinhados às propostas de valor das academias. Ambas as academias atendem parcialmente às promessas de valor, com destaque em áreas distintas que cativaram seus clientes. Os colaboradores expressaram satisfação, mas também sugeriram melhorias. Observou-se diferenças entre as marcas, com a academia de rede aproveitando negociações e parcerias da matriz, enquanto a academia de bairro possui mais liberdade para inovações e estratégias.
Firm characteristics and tax aggressiveness of quoted companies in Nigeria
Authors: Martins Otuedon Ajueyitse , Sule Omoye Alade
Published: June 2024

This study examined the  firm characteristics of tax aggressiveness among quoted companies in Nigeria. The specific objectives were to determine the influence of firm size, profitability, liquidity and leverage on the tax aggressiveness of firms. It was an ex-post-facto and longitudinal study that spanned five years (2015-2019). The population consisted of 87 non-financial companies while the sample size was 67. The data used were from the financial statements and accounts of the sampled companies. The statistical techniques used include descriptive statistics, correlations and random and fixed effects panel least squares regression. The study showed that firm size and profitability have a significant influence and positive relationship with tax aggressiveness while liquidity has no significant influence on tax aggressiveness but has a positive relationship with it. Leverage had a significant influence while having a  negative relationship with tax aggressiveness. It was concluded that firm characteristics are critical factors influencing tax aggressiveness among quoted companies in Nigeria. It recommended that a company's size should not be the basis for tax aggressiveness and that its profitability, liquidity and leverage position be disclosed in a way that accurately reflects its financial status. It will be of immense benefit to companies to ensure that their tax strategies align with ethical and legal standards and that they maintain transparency in their financial reporting. Similarly, the findings of this study have important implications for government tax authorities at both the federal and state levels in terms of the assessment of companies for tax purposes.
Possibilities for active tourist holidays in rural areas in the region of AP Vojvodina, Serbia
Authors: Vukovic Predrag , Andrei Jean Vasile , Kljajic Natasa , Arsic Slavica
Published: June 2024

The subject of the article is to research the possibility of active rural holidays in region of AP Vojvodina (Autonomous Province), with the goal of determining how it can improve tourist competitiveness. The aim is based on the outcome of practical research conducted on the attitudes of tourists and potential tourists about the quality of the supply and the possibilities for active holidays; to identify the elements of tourist supply chain that can have an influence on the active and potential future supply of rural destinations and propose strategic directions for improving their competitiveness. The obtained results of survey provided the opportunity to identify elements in tourist supply chain that are strongest and weakest; analyze current problems pointed out, and suggest strategic ways for further growth of rural tourism. They also suggested the ways to it the competitiveness of rural destinations. AP Vojvodina was selected as the target area for the following reasons: a high level of rural tourism development; the presence of numerous attractive factors that can favor active tourism holidays; high level of economic and social development; and a high level of local population awareness regarding the importance that rural tourism can have for the rise of local economy.
Effect of petrol subsidy removal on government income, cost of living, consumption patterns, savings and investment, and SMEs performance
Authors: Mohammed Suleiman Bala , Khalifa Mohammed Mahmuda , Abubakar Ahmed
Published: June 2024

The purpose of this study is to examine the effect of petrol subsidy removal on government income, cost of living, consumption patterns, savings and investment, and SMEs performance. The study adopted a survey research design, and the population comprised government officials, SME operators, and individual households in the state capital metropolis of the North Central states in Nigeria. We used a convenient sampling technique to select the respondents from a sample size of 483. The study used a questionnaire to collect data, and SmartPLS used partial least squares structural equation modeling for analysis. The study found that petroleum subsidies have a negative and significant effect on consumption patterns, the cost of living, savings and investment, and SME performance. However, it has a positive and significant effect on government income. The study also found that government income and SMEs performance have a positive and significant effect on living standards among people in north-central Nigeria. The study emphasises the need for well-calibrated strategies to minimise the socioeconomic effects of the government's petrol subsidy removal policy. Targeted social safety nets, poverty reduction programmes, and alternative energy investment must balance budgetary sustainability and citizen well-being. SMEs must adjust to changing customer behaviour, and individuals must be encouraged to make smart financial decisions to counterbalance petrol subsidy removal.
Predictors of thirty-day mortality among patients with blood stream infection with WHO priority pathogens: single centre exploratory study from a referral teaching hospital in central India
Authors: Budhiraja Akshit , Karuna Tadepalli , Khan Farhan , Kumar Shweta , Shaji Namitha , Bajaj Ehsaas , Purwar Shashank , Pakhare Abhijit , Joshi Rajnish , Saigal Saurabh , Khadanga Sagar
Published: June 2024

Background and Objectives: Bloodstream infection (BSI) is defined by the presence of viable microorganisms in the blood- stream. BSI is one of the major causes of sepsis and subsequent adverse clinical outcomes all across the globe. The present study was undertaken to identify clinico-epidemio-microbiological variables associated with 30-day mortality in patients having BSI with WHO priority pathogens.
Materials and Methods: The study was conducted at a public sector tertiary care institute in central India from April 2019 to March 2021. Blood samples collected from patients with clinical suspicion of sepsis, were processed by automated bacterial culture system and interpreted as per CLSI guidelines. Calculated sample size was 150. Data was analyzed by R software. Results: Respiratory tract infection was the most common source (43.3%) of BSI, followed by the gastrointestinal (20%) and urinary tract (18.7%). Among the patients, 33% required invasive mechanical ventilation, and 31% required inotropes.  Di- abetes mellitus (DM) was the most common co-morbidity (34%). The incidence of multi-drug resistant organisms (MDRO) was 59.3%. Escherichia coli was the most commonly (24%) isolated organism, followed by Klebsiella pneumoniae (17.3%) and Acinetobacter baumannii (16%).
Conclusion: Higher age, higher qSOFA score / SIRS score / mean SOFA score at presentation had higher mortality. Use of mechanical ventilation and inotropes during treatment and isolation of critical category organisms of WPP and multi drug resistant organisms were independent 30-day mortality predictors.
Application of pulsed-field gel electrophoresis for molecular identification of pathogenic Leptospira species in Iran: a rapid and reliable method
Authors: Khaki Pejvak , Bagherpour Mohsen , Gharakhani Mehdi , Soltani Maryam Sadat , Shahcheraghi Fereshteh , Nikbin Vajihe Sadat
Published: June 2024

Background and Objectives: Leptospirosis is a zoonotic disease caused by pathogenic Leptospira serovars. The genus Leptospira cannot differentiated by conventional techniques. However, identity determination of pathogenic serovar is pre- cious of public health problems and epidemiological studies. Pulsed-field gel electrophoresis facilitates rapid identification of Leptospires to the serovar levels.
Materials and Methods: In this study, we employed PFGE to evaluate 28 Leptospira isolates, with animal, human and en- vironmental origin, obtained from Razi Vaccine and Serum Research Institute of Karaj, Iran. PFGE patterns of 28 Leptospira serovars were generated using the Not I restriction enzyme in comparison with the lambda ladder.
Results: Out of 28 serovars evaluated, we identified 22 different pulsed types, designated P1- P22. Out of 22 pulse groups, 3 were found to be a common type, but others were a single Type. Groups consisting of the common type were P3, P9, P14, and P16. The results showed that the discriminatory index of PFGE by Not I enzyme was 0.99, demonstrating heterogeneous differentiation among serovar members.
Conclusion: The PFGE methodology used in this study showed excellent interlaboratory report usability, rapid, reliable, enabling standardization and data sharing between laboratories.
Effect of collagen hydrogel containing Lavandula officinalis essential oil nanoemulsion in wound healing of infectious burn
Authors: Teymouri Hossein , Mohammadimehr Mojgan , Ahanjan Mohammad , Sheidaei Somayeh , Saeedi Majid , Mellati Amir
Published: June 2024

Background and Objectives: The main cause of mortality in burn patients is infection from burns. Drug-resistant bacteria are the main causes of wound infection, so alternative antibiotic therapies hold significant importance. The objective of this study was to examine the impact of a collagen hydrogel that contains a nanoemulsion of Lavandula essential oil on the heal- ing process of infected burn wounds.
Materials and Methods: In this experimental study, 20 rats were randomly divided after applying burns with a 10 mm diameter hot plate and infecting the wounds with multidrug-resistant Pseudomonas aeruginosa into four groups, including a positive control, a negative control, the first experiment (collagen hydrogel), and the second experiment (collagen hydrogel containing Lavandula essential oil nanoemulsion). On the 4th, 11th, and 18th  days, tissue samples were taken for pathology studies. The important parameters in burn wound healing with hematoxylin and eosin and Masson's trichrome staining meth- ods were investigated and scored according to Abramov’s method.
Results: Based on the pathology findings, experimental groups 1 and 2 compared to the negative and positive control groups were effective in rat infection wound healing. The hydrogel scaffold in the experimental groups increased fibroblasts and an- giogenesis compared to the control groups. Epithelization was noticed only in the hydrogel group containing nanoemulsion.
Conclusion: The study findings suggest that the use of collagen hydrogel with Lavandula essential oil nanoemulsion has potential as a wound dressing. This is because it has the potential to effectively promote healing and act as an antibacterial agent to prevent infections.
Designing the fusion protein of rotavirus VP8 and hepatitis A virus VP1 and evaluating the immunological response in BALB/c mice
Authors: Yarmohammadi Hassan , Aghasadeghi Mohammadreza , Sepahi Abbas Akhavan , Hamidi-fard Mojtaba , Bahramali Golnaz
Published: June 2024

Background and Objectives: Rotavirus and Hepatitis A virus are responsible for causing gastroenteritis and jaundice. The current vaccination approaches have proven insufficient, especially in low-income countries. In this study, we presented a novel dual-vaccine candidate that combines the rotavirus VP8 protein and the hepatitis A virus VP1.
Materials and Methods: The VP8*-rotavirus+AAY+HAV-VP1 fusion protein was produced using an Escherichia coli expression system. The recombinant protein had a molecular weight of approximately 45.5 kDa and was purified through affinity chromatography. BALB/c mice were injected subcutaneously with the recombinant protein, VP1, VP8 and vaccines for rotavirus and hepatitis A virus, both with and without ALUM and M720 adjuvants. ELISA assays were used to measure total IgG, IgG1, IgG2, and short-term and long-term IL-5 and IFN-γ responses.
Results: The fusion protein, when combined with adjuvants, elicited significantly higher total IgG, IgG1, and IgG2 re- sponses compared to VP1 and VP8 alone, as well as the rotavirus and hepatitis A vaccines. Furthermore, it induced a higher short-term IL-5 and IFN-γ response while demonstrating a higher long-term IL-5 response compared to the rotavirus and hepatitis A vaccines.
Conclusion: This study demonstrates that the VP8*-rotavirus+AAY+HAV-VP1 fusion protein is a promising dual vaccine candidate for immunization against hepatitis A and rotaviruses.
Type-specific human papillomavirus prevalence in women referred for colposcopy in Tehran
Authors: Soleimani-Jelodar Rahim , Arashkia Arash , Shoja Zabihollah , Sharifian Kimia , Akhavan Setareh , Yarandi Fariba , Jalilvand Somayeh
Published: June 2024

Background and Objectives: Although several studies have been achieved on the frequency of the HPV types among wom- en with cervical cancer in Iran, HPV-positive samples were in some cases directed to specific-primer genotyping of HPV 16 and 18. Therefore, the other HPV types are underestimated. Several studies have also reported a greater prevalence of HPV 16 in cervical cancer in Iran than in the world. To clarify these subjects, the distribution of HPV types in women referred for colposcopy in Tehran was investigated.
Materials and Methods: In this cross-sectional study, a total of 148 cervical samples from women with normal, atypical squamous cells of undetermined significance, cervical intraepithelial neoplasia I-III, and invasive cervical cancer histopa- thology were included. HPV was detected by PCR assay and all HPV-positive specimens were subjected to direct nucleotide sequencing.
Results: Our results demonstrated that the total prevalence of HPV was 92.5%. The five most common HPV types were HPV 16 (49.3%), 18 (14.8%), 6 (7.4%), 31 (4.1%), and 11 (2.7%). About the histopathological stage, HPV 16 and 18 were dominant in all studied groups. In cervical cancer, HPV 16 and 18 were detected in 60% and 20% of cases, respectively.
Conclusion: HPV 16 and 18 were the most common in cervical cancer in Iran.