bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 3 from Antigen Shedding May Improve Efficiencies for Delivery of Antibody-Based Anticancer Agents in Solid Tumors
Authors: Pak Youngshang , Zhang Yujian , Pastan Ira , Lee Byungkook
Published: March 2023

PDF file - 39K, Position profile of the ECS concentration of complexed RIT at different times
Supplementary Table 2 from Resistance to Selective BRAF Inhibition Can Be Mediated by Modest Upstream Pathway Activation
Authors: Su Fei , Bradley William D. , Wang Qiongqing , Yang Hong , Xu Lizhong , Higgins Brian , Kolinsky Kenneth , Packman Kathryn , Kim Min Jung , Trunzer Kerstin , Lee Richard J. , Schostack Kathleen , Carter Jade , Albert Thomas , Germer Soren , Rosinski Jim , Martin Mitchell , Simcox Mary Ellen , Lestini Brian , Heimbrook David , Bollag Gideon
Published: March 2023

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Supplementary Table 2 from ESE3/EHF Controls Epithelial Cell Differentiation and Its Loss Leads to Prostate Tumors with Mesenchymal and Stem-like Features
Authors: Albino Domenico , Longoni Nicole , Curti Laura , Mello-Grand Maurizia , Pinton Sandra , Civenni Gianluca , Thalmann George , D'Ambrosio Gioacchino , Sarti Manuela , Sessa Fausto , Chiorino Giovanna , Catapano Carlo V. , Carbone Giuseppina M.
Published: March 2023

PDF file - 1MB, Genes differentially expressed in ESE3KD-PrECs compared to control PrECs
Supplementary Table 7 from Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression
Authors: Hilvo Mika , Denkert Carsten , Lehtinen Laura , Müller Berit , Brockmöller Scarlet , Seppänen-Laakso Tuulikki , Budczies Jan , Bucher Elmar , Yetukuri Laxman , Castillo Sandra , Berg Emilia , Nygren Heli , Sysi-Aho Marko , Griffin Julian L. , Fiehn Oliver , Loibl Sibylle , Richter-Ehrenstein Christiane , Radke Cornelia , Hyötyläinen Tuulia , Kallioniemi Olli , Iljin Kristiina , Orešič Matej
Published: March 2023

Supplementary Table 7 from Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression
Supplementary Figure Legends 1-6 from Transcriptional Signatures of Ral GTPase Are Associated with Aggressive Clinicopathologic Characteristics in Human Cancer
Authors: Smith Steven C. , Baras Alexander S. , Owens Charles R. , Dancik Garrett , Theodorescu Dan
Published: March 2023

PDF file - 79K
Supplementary Figure 1 from Protein Tyrosine Phosphatase Shp2 (Ptpn11) Plays an Important Role in Maintenance of Chromosome Stability
Authors: Liu Xia , Zheng Hong , Qu Cheng-Kui
Published: March 2023

PDF file - 27K, Shp2 depletion decreases taxol-induced mitotic arrest
Supplementary Tables 1-7 from miR-23b Represses Proto-oncogene Src Kinase and Functions as Methylation-Silenced Tumor Suppressor with Diagnostic and Prognostic Significance in Prostate Cancer
Authors: Majid Shahana , Dar Altaf A. , Saini Sharanjot , Arora Sumit , Shahryari Varahram , Zaman Mohd Saif , Chang Inik , Yamamura Soichiro , Tanaka Yuichiro , Deng Guoren , Dahiya Rajvir
Published: March 2023

PDF file - 217K, Supplemental Table 1. Clinicopathologic characteristics of prostate cancer patients. Supplemental Table 2. Multiple Regression Enter Method. Supplemental Table 3. Multiple Regression Forward Method. Supplemental Table 4. Multiple Regression Backward Method. Supplemental Table 5. Multiple Regression Stepwise Method. Supplemental Table 6: Correlation between methylation status and miR-23b expression. Supplemental Table 7. Complimentary sequences in 3'UTRs of Src kinase and Akt for miR-23b and sequences of primers and probes
Supplementary Figure 2 from miR-23b Represses Proto-oncogene Src Kinase and Functions as Methylation-Silenced Tumor Suppressor with Diagnostic and Prognostic Significance in Prostate Cancer
Authors: Majid Shahana , Dar Altaf A. , Saini Sharanjot , Arora Sumit , Shahryari Varahram , Zaman Mohd Saif , Chang Inik , Yamamura Soichiro , Tanaka Yuichiro , Deng Guoren , Dahiya Rajvir
Published: March 2023

PDF file - 1.3MB, Larger pictures of Figure 4B
Supplementary Tables 1-2 from Deficiency in Mammalian Histone H2B Ubiquitin Ligase Bre1 (Rnf20/Rnf40) Leads to Replication Stress and Chromosomal Instability
Authors: Chernikova Sophia B. , Razorenova Olga V. , Higgins John P. , Sishc Brock J. , Nicolau Monica , Dorth Jennifer A. , Chernikova Diana A. , Kwok Shirley , Brooks James D. , Bailey Susan M. , Game John C. , Brown J. Martin
Published: March 2023

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Supplementary Table 1 from SIRT1 Pathway Dysregulation in the Smoke-Exposed Airway Epithelium and Lung Tumor Tissue
Authors: Beane Jennifer , Cheng Luis , Soldi Raffaella , Zhang Xiaohui , Liu Gang , Anderlind Christina , Lenburg Marc E. , Spira Avrum , Bild Andrea H.
Published: March 2023

Excel file, 68K, Pathway gene expression signatures. The ENTREZ Gene ID, pathway, and gene description are listed for each set of 100 genes derived based on the Affymetrix Exon 1.0 ST microarray, the Affymetrix HuGene 1.0 ST microarray, the Affymetrix HGU133 Plus 2.0 microarray, and for the set in common to the microarrays listed previously and the Affymetrix HGU133A microarray.
Supplementary Figure 4 from SIRT1 Pathway Dysregulation in the Smoke-Exposed Airway Epithelium and Lung Tumor Tissue
Authors: Beane Jennifer , Cheng Luis , Soldi Raffaella , Zhang Xiaohui , Liu Gang , Anderlind Christina , Lenburg Marc E. , Spira Avrum , Bild Andrea H.
Published: March 2023

PDF file, 72 K, SIRT1 pathway activation in lung tumor tissue datasets with smoking-status or different tumor subtypes. A. Lung tumor tissue (n=60, 56 adenocarcinomas, 1 squamous, 3 bronchioloalveolar carcinoma) and paired adjacent normal lung tissue (n=60) (GSE19804) from non-smoking women in Taiwan hybridized to Affymetrix HGU133 Plus 2.0 microarrays. There was no different between SIRT1 pathway activation between adjacent normal and tumor tissue. B. Top left. Adjacent normal lung tissue and paired lung tumor tissue (n=42 pairs, n=22 adenocarcinoma, n=9 large cell carcinoma, and n=11 squamous cell carcinoma) (GSE19188) hybridized to Affymetrix HGU133 Plus 2.0 microarrays. SIRT1 pathway activation was decreased between adenocarcinomas and normal lung tissue (ADC, p=0.044) and between large cell carcinomas and normal lung tissue (LCC, p=0.002); however, SIRT1 pathway activation was significantly increased in squamous cell carcinoma compared to adjacent normal lung tissue (SCC, p=0.023). Top middle. Adenocarcinoma (ADC, n=40) and squamous cell carcinoma (SCC, n=18) lung tumor tissue (GSE10245) was hybridized to Affymetrix HGU133 Plus 2.0 microarrays. SIRT1 pathway activation was significantly higher in SCC versus ADC tumors (p<0.001). Top right. Adenocarcinoma (ADC, n=50), large cell carcinoma (LCC, n=20), and squamous cell carcinoma (SCC, n=28) lung tumor tissue (GSE28571) was hybridized to Affymetrix HGU133 Plus 2.0 microarrays. SIRT1 pathway activation was significantly higher in SCC versus ADC tumors (p<0.001). Bottom left. Adenocarcinoma (ADC, n=58) and squamous cell carcinoma (SCC, n=53) lung tumor tissue (GSE3141) was hybridized to Affymetrix HGU133 Plus 2.0 microarrays. SIRT1 pathway activation is significantly lower in ADC versus SCC tumors (p<0.001). Bottom middle. CCLE lung cancer cell lines (n=180) that include n=49 adenocarcinoma (ADC), n=5 bronchioloalveolar adenocarcinoma (BAC), n=14 large cell carcinoma (LCC) , n=4 mixed adenosquamous carcinoma (Mixed ADC/SCC), n=1 mucoepidermoid carcinoma (mucoepidermoid), n=24 non-small cell carcinoma (NSCLC), n=53 small cell carcinoma (SCLC), n=26 squamous cell carcinoma (SCC), n=1 undifferentiated carcinoma (UnDiff), and n=3 Unknown.
Supplementary Figure 2 from SIRT1 Pathway Dysregulation in the Smoke-Exposed Airway Epithelium and Lung Tumor Tissue
Authors: Beane Jennifer , Cheng Luis , Soldi Raffaella , Zhang Xiaohui , Liu Gang , Anderlind Christina , Lenburg Marc E. , Spira Avrum , Bild Andrea H.
Published: March 2023

PDF file,79K, Pathway activation predictions for each control dataset. A. ATM pathway activation is increased in H1299 and transiently decreased and then restored in H460 cells exposed to 2 Gy of ionizing radiation (IR). RNA from the cells was sampled pre-exposure (n=12) and at various time points post-exposure (n=30) and hybridized to Affymetrix Gene 1.0 ST microarray (GSE20549). B. GPX1 pathway activation is decreased in response to a selenium deficient diet. Rats were fed selenium deficient diets (n=3) or supplemented with sodium selenite up to 5ug/g for 28 days (n=15). Rat livers were harvested and RNA was isolated and hybridized to Affymetrix Rat Genome 230 2.0 microarrays (GSE23895). C. IKBKB pathway activation is increased after retrovirus infection with the IKBKB. H929 and SACHI cells lines were infected with retroviruses containing MAP3K14 (n=6), IKBKB (n=6) compared with controls were no infection was conducted (n=6). RNA was isolated and hybridized to Affymetrix HGU133 Plus 2.0 microarrays (GSE18047). D. SIRT1 pathway activation is increased in A549 cells treated with resveratrol. A549 cells treated with an ethanol control (n=1) or 25 microM of resveratrol (n=3) for 48h and RNA was hybridized to Affymetrix HGU133 Plus 2.0 microarrays (GSE9008). E. SIRT1 pathway activity is decreased in the SIRT1 knockdown compared to the control. MCF-7 cells were treated with two retroviral constructs, a shRNA to knockdown SIRT1 (n=3), and a shRNA directed against Luciferase (n=3) and RNA was hybridized to Affymetrix HGU133A 2.0 microarrays (GSE13459). F. SIRT1 pathway activation was increased in cells treated with tobacco smoke condensate (TSC). A549 cells or Calu-6 cells were cultured with and without TSC and hybridized to Affymetrix HGU133 Plus 2.0 microarrays (GSE13309). For each cells type, there were 3 controls and 9 samples treated with TSC.
Supplementary Methods from Targeting BRCA1 Localization to Augment Breast Tumor Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
Authors: Yang Eddy S. , Nowsheen Somaira , Rahman Mohammad A. , Cook Rebecca S. , Xia Fen
Published: March 2023

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Supplementary Figure 1 from SIRT1 Pathway Dysregulation in the Smoke-Exposed Airway Epithelium and Lung Tumor Tissue
Authors: Beane Jennifer , Cheng Luis , Soldi Raffaella , Zhang Xiaohui , Liu Gang , Anderlind Christina , Lenburg Marc E. , Spira Avrum , Bild Andrea H.
Published: March 2023

PDF file,51K, Principal component analysis of expression estimates for pathway perturbation data. A. The samples are colored by pathway: ATM (red), BCL2 (blue), GPX1 (purple), IKBKB (orange), NOS2 (pink), SIRT1 (gray), and GFP (black). B. The samples are colored by batch: batch 1 (red), batch 2 (blue), batch 3 (black), batch 4 (orange). Samples in batch 3 were eliminated from the analyses in the paper.
Supplementary Figures 1-4 from Bone Marrow Stroma–Secreted Cytokines Protect JAK2V617F-Mutated Cells from the Effects of a JAK2 Inhibitor
Authors: Manshouri Taghi , Estrov Zeev , Quintás-Cardama Alfonso , Burger Jan , Zhang Ying , Livun Ana , Knez Liza , Harris David , Creighton Chad J. , Kantarjian Hagop M. , Verstovsek Srdan
Published: March 2023

Supplementary Figures 1-4 from Bone Marrow Stroma–Secreted Cytokines Protect JAK2V617F-Mutated Cells from the Effects of a JAK2 Inhibitor
Supplementary Figure 4 from RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2
Authors: Wang Hongyan , Liu Kaihua , Geng Miao , Gao Peng , Wu Xiaoyuan , Hai Yan , Li Yangxia , Li Yulong , Luo Lin , Hayes John D. , Wang Xiu Jun , Tang Xiuwen
Published: March 2023

PDF file - 160K, tBHQ increased the expression of AKR1C in MCF7 cells.
Supplementary Figure S3 from Mitogenic Insulin Receptor-A Is Overexpressed in Human Hepatocellular Carcinoma due to EGFR-Mediated Dysregulation of RNA Splicing Factors
Authors: Chettouh Hamza , Fartoux Laetitia , Aoudjehane Lynda , Wendum Dominique , Clapéron Audrey , Chrétien Yves , Rey Colette , Scatton Olivier , Soubrane Olivier , Conti Filomena , Praz Françoise , Housset Chantal , Rosmorduc Olivier , Desbois-Mouthon Christèle
Published: March 2023

Supplementary Figure S3 - PDF file 53K, Basal and EGFR-activated ERK levels in HCC cell lines
Supplementary Figure 2 from Oncolytic Virus and Anti–4-1BB Combination Therapy Elicits Strong Antitumor Immunity against Established Cancer
Authors: John Liza B. , Howland Linda J. , Flynn Jacqueline K. , West Alison C. , Devaud Christel , Duong Connie P. , Stewart Trina J. , Westwood Jenny A. , Guo Z. Sheng , Bartlett David L. , Smyth Mark J. , Kershaw Michael H. , Darcy Phillip K.
Published: March 2023

PDF file - 192K
Supplementary Table 4 from Cisplatin Sensitivity Mediated by WEE1 and CHK1 Is Mediated by miR-155 and the miR-15 Family
Authors: Pouliot Lynn M. , Chen Yu-Chi , Bai Jennifer , Guha Rajarshi , Martin Scott E. , Gottesman Michael M. , Hall Matthew D.
Published: March 2023

XLs file - 164K, Results from kinome siRNA screen
Supplementary Figures 1-5, Tables 1-2, Table Legends 3-4 from Cisplatin Sensitivity Mediated by WEE1 and CHK1 Is Mediated by miR-155 and the miR-15 Family
Authors: Pouliot Lynn M. , Chen Yu-Chi , Bai Jennifer , Guha Rajarshi , Martin Scott E. , Gottesman Michael M. , Hall Matthew D.
Published: March 2023

PDF file - 4MB, Fig S1: Schematic demonstrating the objective of the high throughput screen Fig S2: Expression of miR family members in KB-3-1 and KB-CP.5 cells Fig S3: Expression of miR family members in KB-3-1 transfected with miR-15a mimic Fig S4: Expression of WEE1, CHEK1 and ATR in KB-CP.5 cells transfected with one of six siRNA against each gene Fig S5: Representative cell viability analysis dot blots of KB-3-1 and KB-CP.5 cells transfected with either siNeg, miR-16 mimic or miR-16 inhibitor alone or in the presence of cisplatin Fig S6: Representative cell cycle analysis histograms of KB-3-1 and KB-CP.5 cells transfected with either siNeg, miR-16 mimic or miR-16 inhibitor alone or in the presence of cisplatin Table S1: Protocol for the high-throughput screens Table S2: Cytotoxicity (IC50) values for KB-3-1 and KB-CP.5 lines with and without miRNA mimics or miRNA siRNA (inhibitors), and challenged with cisplatin
Supplementary Figure Legends 1-3 from Multiple Roles of p53-Related Pathways in Somatic Cell Reprogramming and Stem Cell Differentiation
Authors: Yi Lan , Lu Chiwei , Hu Wenwei , Sun Yvonne , Levine Arnold J.
Published: March 2023

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Supplementary Figure 7 from Cardiac Inflammation after Local Irradiation Is Influenced by the Kallikrein-Kinin System
Authors: Sridharan Vijayalakshmi , Tripathi Preeti , Sharma Sunil K. , Moros Eduardo G. , Corry Peter M. , Lieblong Benjamin J. , Kaschina Elena , Unger Thomas , Thöne-Reineke Christa , Hauer-Jensen Martin , Boerma Marjan
Published: March 2023

PDF file - 405K, Full-length Western-Blots of left ventricular expression of total and phosphorylated Akt and Erk1/2 at 3 months after sham-irradiation or local heart irradiation with 24 Gy in BN and BN/Ka rats
Supplementary Figure 3 from RNF8 Regulates Assembly of RAD51 at DNA Double-Strand Breaks in the Absence of BRCA1 and 53BP1
Authors: Nakada Shinichiro , Yonamine Rikako Miyamoto , Matsuo Koichi
Published: March 2023

PDF file - 666K, RAD51 assembles at DSB sites in RNF8-/- MEFs
Supplementary Figure S1 from LIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer
Authors: Permuth-Wey Jennifer , Kim Donghwa , Tsai Ya-Yu , Lin Hui-Yi , Chen Y. Ann , Barnholtz-Sloan Jill , Birrer Michael J. , Bloom Gregory , Chanock Stephen J. , Chen Zhihua , Cramer Daniel W. , Cunningham Julie M. , Dagne Getachew , Ebbert-Syfrett Judith , Fenstermacher David , Fridley Brooke L. , Garcia-Closas Montserrat , Gayther Simon A. , Ge William , Gentry-Maharaj Aleksandra , Gonzalez-Bosquet Jesus , Goode Ellen L. , Iversen Edwin , Jim Heather , Kong William , McLaughlin John , Menon Usha , Monteiro Alvaro N.A. , Narod Steven A. , Pharoah Paul D.P. , Phelan Catherine M. , Qu Xiaotao , Ramus Susan J. , Risch Harvey , Schildkraut Joellen M. , Song Honglin , Stockwell Heather , Sutphen Rebecca , Terry Kathryn L. , Tyrer Jonathan , Vierkant Robert A. , Wentzensen Nicolas , Lancaster Johnathan M. , Cheng Jin Q. , Sellers Thomas A.
Published: March 2023

Supplementary Figure S1 from LIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer
Supplementary Figure 1 from Interstitial Fluid Pressure and Associated Lymph Node Metastasis Revealed in Tumors by Dynamic Contrast-Enhanced MRI
Authors: Hompland Tord , Ellingsen Christine , Øvrebø Kirsti Marie , Rofstad Einar K.
Published: March 2023

PDF file - 25K, Figure showing IFP and v0 versus tumor size for TS-415 and U-25 tumors
Supplementary Table 2 from Gliomagenesis Arising from Pten- and Ink4a/Arf-Deficient Neural Progenitor Cells Is Mediated by the p53-Fbxw7/Cdc4 Pathway, Which Controls c-Myc
Authors: Kim Hong Sug , Woolard Kevin , Lai Chen , Bauer Peter O. , Maric Dragan , Song Hua , Li Aiguo , Kotliarova Svetlana , Zhang Wei , Fine Howard A.
Published: March 2023

PDF file, 345K, Tumors and p53 mutations. All tumors contained one of two different types of p53 mutations (Cys132Trp and Arg270Cys).
Supplementary Figure 4 from Gliomagenesis Arising from Pten- and Ink4a/Arf-Deficient Neural Progenitor Cells Is Mediated by the p53-Fbxw7/Cdc4 Pathway, Which Controls c-Myc
Authors: Kim Hong Sug , Woolard Kevin , Lai Chen , Bauer Peter O. , Maric Dragan , Song Hua , Li Aiguo , Kotliarova Svetlana , Zhang Wei , Fine Howard A.
Published: March 2023

PDF file, 111K, Substrates of Fbxw7
Supplementary Methods from Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis
Authors: Young Nathan P. , Crowley Denise , Jacks Tyler
Published: March 2023

Supplementary Methods from Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis
Supplementary Table 1 from The CRTC1-NEDD9 Signaling Axis Mediates Lung Cancer Progression Caused by LKB1 Loss
Authors: Feng Yan , Wang Ye , Wang Zuoyun , Fang Zhaoyuan , Li Fei , Gao Yijun , Liu Hongyan , Xiao Tian , Li Fuming , Zhou Yang , Zhai Qiwei , Liu Xiaolong , Sun Yihua , Bardeesy Nabeel , Wong Kwok-kin , Chen Haiquan , Xiong Zhi-qi , Ji Hongbin
Published: March 2023

PDF file - 139K, The list of primers used in this study
Supplementary Figure Legends 1-12 from The CRTC1-NEDD9 Signaling Axis Mediates Lung Cancer Progression Caused by LKB1 Loss
Authors: Feng Yan , Wang Ye , Wang Zuoyun , Fang Zhaoyuan , Li Fei , Gao Yijun , Liu Hongyan , Xiao Tian , Li Fuming , Zhou Yang , Zhai Qiwei , Liu Xiaolong , Sun Yihua , Bardeesy Nabeel , Wong Kwok-kin , Chen Haiquan , Xiong Zhi-qi , Ji Hongbin
Published: March 2023

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Supplementary Figure 3 from Estrogen Receptor Alpha Mediates Progestin-Induced Mammary Tumor Growth by Interacting with Progesterone Receptors at the Cyclin D1/MYC Promoters
Authors: Giulianelli Sebastián , Vaqué José P. , Soldati Rocío , Wargon Victoria , Vanzulli Silvia I. , Martins Rubén , Zeitlin Eduardo , Molinolo Alfredo A. , Helguero Luisa A. , Lamb Caroline A. , Gutkind J. Silvio , Lanari Claudia
Published: March 2023

PDF file - 177K, T47D cells were starved and then treated or not with MPA for 10 min, and processed for immunofluorescence and confocal microscopy using specific antibodies to detect pSer162 PRB and ER� (SP1, A) or pSer294 PR and ER� (M7047, B). Bar: 15�m. Co-localization between nuclear receptors was quantified using the quantitative statistical analysis for nuclear pixel overlap after 10 min of MPA treatment and was estimated using the Pearson's correlation coefficient. (C) Cellular fractionation of T47D cells was controlled by Western blot using anti-tubulin (cytoplasmatic marker, Ab4 from Thermo) or anti-Sp1 (nuclear marker, from Thermo) antibodies. Erk1/2 was used as a loading control. (D) T47D cells were starved and then treated with ICI during 3, 6, 12, 24 and 48 h. ER� (SP1) and PR (Ab7) expression was analyzed by Western blot. Erk1/2 was used as a loading control.
Supplementary Figure Legend from An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin
Authors: Garner Andrew P. , Bialucha Carl U. , Sprague Elizabeth R. , Garrett Joan T. , Sheng Qing , Li Sharon , Sineshchekova Olga , Saxena Parmita , Sutton Cammie R. , Chen Dongshu , Chen Yan , Wang Huiqin , Liang Jinsheng , Das Rita , Mosher Rebecca , Gu Jian , Huang Alan , Haubst Nicole , Zehetmeier Carolin , Haberl Manuela , Elis Winfried , Kunz Christian , Heidt Analeah B. , Herlihy Kara , Murtie Joshua , Schuller Alwin , Arteaga Carlos L. , Sellers William R. , Ettenberg Seth A.
Published: March 2023

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Supplementary Figures from Src Family Kinases as Novel Therapeutic Targets to Treat Breast Cancer Brain Metastases
Authors: Zhang Siyuan , Huang Wen-Chien , Zhang Lin , Zhang Chenyu , Lowery Frank J. , Ding Zhaoxi , Guo Hua , Wang Hai , Huang Suyun , Sahin Aysegul A. , Aldape Kenneth D. , Steeg Patricia S. , Yu Dihua
Published: March 2023

PDF file, 217K, Supplementary Figure 1-6 Supplementary Fig. 1 Activation of Src pathway promotes BT474 cell invasion. Supplementary Fig. 2. Wild-type Src overexpression in tumor cells promotes brain metastasis in vivo. Supplementary Fig. 3 Inhibition of cell migration by Src inhibitor saracatinib detected by wound healing assay. Supplementary Fig. 4 Combinatorial treatment of lapatinib and Src inhibitor inhibits invasion capability of BT474.Br cells. Supplementary Fig. 5 Inhibition of Src activity in brain metastases by Src inhibitor saracatinib. Supplementary Fig. 6 Densitometric analysis of three western blots of cyclin D1 of the indicated cell lines using ImageJ software (NIH).
Supplementary Figures from Double Minute Chromosomes in Glioblastoma Multiforme Are Revealed by Precise Reconstruction of Oncogenic Amplicons
Authors: Sanborn J. Zachary , Salama Sofie R. , Grifford Mia , Brennan Cameron W. , Mikkelsen Tom , Jhanwar Suresh , Katzman Sol , Chin Lynda , Haussler David
Published: March 2023

PDF file, 215K, Reconstructing circular amplicons (S1); TCGA-GBM-06-0152 harbors 2 circular amplicons (S2); Cumulative number of peaks called in 264 GBM exomes as a function of the tumor vs. matched normal relative coverage threshold used to define a peak (S3).
Supplementary Table 2 from Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening
Authors: Tyner Jeffrey W. , Yang Wayne F. , Bankhead Armand , Fan Guang , Fletcher Luke B. , Bryant Jade , Glover Jason M. , Chang Bill H. , Spurgeon Stephen E. , Fleming William H. , Kovacsovics Tibor , Gotlib Jason R. , Oh Stephen T. , Deininger Michael W. , Zwaan Christian Michel , Den Boer Monique L. , van den Heuvel-Eibrink Marry M. , O'Hare Thomas , Druker Brian J. , Loriaux Marc M.
Published: March 2023

XLS file - 79K, Patient Clinical Information
Supplementary Table 1 from VEGF-C and VEGF-D Blockade Inhibits Inflammatory Skin Carcinogenesis
Authors: Alitalo Annamari K. , Proulx Steven T. , Karaman Sinem , Aebischer David , Martino Stefania , Jost Manuela , Schneider Nicole , Bry Maija , Detmar Michael
Published: March 2023

PDF - 75K, Levels of macrophage- and macrophage polarizationassociated cytokines.
Supplementary Table 1 from Stress-Response Protein RBM3 Attenuates the Stem-like Properties of Prostate Cancer Cells by Interfering with CD44 Variant Splicing
Authors: Zeng Yu , Wodzenski Dana , Gao Dong , Shiraishi Takumi , Terada Naoki , Li Youqiang , Vander Griend Donald J. , Luo Jun , Kong Chuize , Getzenberg Robert H. , Kulkarni Prakash
Published: March 2023

Supplementary Table 1 - PDF file 43K, mRNA expression of stem cell-related gene using a Stem Cell PCR array
Supplementary Figure 2 from Application of a Proapoptotic Peptide to Intratumorally Spreading Cancer Therapy
Authors: Chen Renwei , Braun Gary B. , Luo Xiuquan , Sugahara Kazuki N. , Teesalu Tambet , Ruoslahti Erkki
Published: March 2023

PDF file - 7120K, Figure S2. N-terminal fragments of Bit1 cause cell death.
Supplementary Figure 1 from Application of a Proapoptotic Peptide to Intratumorally Spreading Cancer Therapy
Authors: Chen Renwei , Braun Gary B. , Luo Xiuquan , Sugahara Kazuki N. , Teesalu Tambet , Ruoslahti Erkki
Published: March 2023

PDF file - 3336K, Figure S1. Construction and identification of recombinant proteins from Bit1 cell death domain.
Supplementary Figure 4 from Stress-Response Protein RBM3 Attenuates the Stem-like Properties of Prostate Cancer Cells by Interfering with CD44 Variant Splicing
Authors: Zeng Yu , Wodzenski Dana , Gao Dong , Shiraishi Takumi , Terada Naoki , Li Youqiang , Vander Griend Donald J. , Luo Jun , Kong Chuize , Getzenberg Robert H. , Kulkarni Prakash
Published: March 2023

Supplementary Figure 4 - PDF file 146K, mRNA expression of Cyclin D1 was evaluated in PC3 cells (A) and DU145 cells (B) that formed colonies in soft agar or those grew in the regular 2D culture condition by qRT-PCR. Values are mean � s.d. (n = 4). (C), PC3 cells were cultured under 32˚C for 0 hr to 144 hr, and mRNA level of cyclin D1 was detected by qRT-PCR. Values are mean � s.d. (n = 4). (D) Over-expression of CD44 variant and standard construct. LNCaP cells were transfected with pLenti-III-CD44s (CD44s), pLenti-III-CD44v8-v10 (CD44v8-10) or empty vector. After 48 hr of transfection, cells were collected and the expression of mRNA and protein of CD44 were detected by RT-PCR and Western blot, respectively. Data are mean � s.d. (n = 3), *P < 0.05
Supplementary Figure 3 from Constitutive HER2 Signaling Promotes Breast Cancer Metastasis through Cellular Senescence
Authors: Angelini Pier Davide , Fluck Mariano F. Zacarias , Pedersen Kim , Parra-Palau Josep Lluís , Guiu Marc , Bernadó Morales Cristina , Vicario Rocio , Luque-García Antonio , Navalpotro Nerea Peiró , Giralt Jordi , Canals Francesc , Gomis Roger R. , Tabernero Josep , Baselga José , Villanueva Josep , Arribas Joaquín
Published: March 2023

PDF file - 62K, The tyrosine kinase inhibitor lapatinib does not revert the cellular senescence induced by p95HER2
Supplementary Table S5 from Alkaline Phosphatase ALPPL-2 Is a Novel Pancreatic Carcinoma-Associated Protein
Authors: Dua Pooja , Kang Hye Suk , Hong Seung-Mo , Tsao Ming-Sound , Kim Soyoun , Lee Dong-ki
Published: March 2023

Supplementary Table S5 PDF file - 179K, Table S5. Gene expression data comprising of genes with >1.5 fold up-regulation in expression upon siRNA mediated ALPPL2 knockdown
Supplementary Figures 1 - 9 from ATR-Dependent Phosphorylation of FANCM at Serine 1045 Is Essential for FANCM Functions
Authors: Singh Thiyam Ramsing , Ali Abdullah Mahmood , Paramasivam Manikandan , Pradhan Arun , Wahengbam Kebola , Seidman Michael M. , Meetei Amom Ruhikanta
Published: March 2023

PDF file - 407K, DNA-damage-induced phosphorylation of FANCM is ATR dependent (S1); Peptides released from FANCM protein were analyzed for putative phosphorylation sites by mass spectrometry (S2); Immunoblot showing that antibody raised against phosphorylated S1045 specifically recognizes the ectopically expressed wildtype, but not S1045A mutant, form of FANCM (S3); UV mediated DNA-damage-induced phosphorylation of FANCM at S1045 (S4); Phosphorylation at S1045 is not required for FANCM binding to the FA core complex but for FANCD2 monoubiquitination (S5); MMC-induced chromatin association of the FA-core complex is impaired in S1045A-expressing cells (S6); Recruitment of FANCM to ICL site is ATR dependent (S7); S1045A mutant-expressing cells do not show any gross change in cell-cycle distribution (S8); Expression of FLAG tagged FANCMK117R in the context of knockdown of the endogenous protein (S9).
Supplementary Figure 2 from Mutationally Activated PIK3CAH1047R Cooperates with BRAFV600E to Promote Lung Cancer Progression
Authors: Trejo Christy L. , Green Shon , Marsh Victoria , Collisson Eric A. , Iezza Gioia , Phillips Wayne A. , McMahon Martin
Published: March 2023

PDF file, 161K, BRAFV600E/PIK3CAH1047R expressing lung tumors are clonally derived.
Supplementary Figure Legends from Cyclin D1 Integrates Estrogen-Mediated DNA Damage Repair Signaling
Authors: Li Zhiping , Chen Ke , Jiao Xuanmao , Wang Chenguang , Willmarth Nicole E. , Casimiro Mathew C. , Li Weihua , Ju Xiaoming , Kim Sung Hoon , Lisanti Michael P. , Katzenellenbogen John A. , Pestell Richard G.
Published: March 2023

PDF file - 22KB
Supplementary Video 2 from Senescent Fibroblasts in Melanoma Initiation and Progression: An Integrated Theoretical, Experimental, and Clinical Approach
Authors: Kim Eunjung , Rebecca Vito , Fedorenko Inna V. , Messina Jane L. , Mathew Rahel , Maria-Engler Silvya S. , Basanta David , Smalley Keiran S.M. , Anderson Alexander R.A.
Published: March 2023

MOV file - 5102K, This video shows the spatio-temporal evolution of vSkin that produced Figure 4A (wound healing).
Supplementary Figure S3 from mTOR Complex 2 Is Involved in Regulation of Cbl-Dependent c-FLIP Degradation and Sensitivity of TRAIL-Induced Apoptosis
Authors: Zhao Liqun , Yue Ping , Khuri Fadlo R. , Sun Shi-Yong
Published: March 2023

Supplementary Figure S3 PDF file - 99K, Impact of stable knockdown of rictor or raptor on the expression of c-FLIP and survivin in A549 cells
Supplementary Information from Hyperactivated JNK Is a Therapeutic Target in pVHL-Deficient Renal Cell Carcinoma
Authors: An Jiabin , Liu Huiren , Magyar Clara E. , Guo Yanchuan , Veena Mysore S. , Srivatsan Eri S. , Huang Jiaoti , Rettig Matthew B.
Published: March 2023

Supplementary Information PDF file - 24991K, Hyperactivated c-Jun N-terminal Kinase as a Therapeutic Target in pVHL-Deficient Renal Cell Carcinomas. Supplementary Materials and Methods. Six (6) supplementary figures. Two (2) supplementary tables. Supplementary Figure S1. pVHL and HIF1� levels in isogenic pairs of RCC cell lines. Supplementary Figure S2. JNK regulates AP1 activity. Supplementary Figure S3. CARD9 silencing inhibits TAK1 functional activity. Supplementary Figure S4. JNK/AP1-dependent EMT in pVHL-deficient RCCs. Supplementary Figure S5. Changes in expression of cadherins and transcription factors resulting from pharmacologic inhibition of JNK in pVHL-deficient cells Supplementary Figure S6. Inhibition of JNK or c-Jun reduces the invasiveness of pVHL-deficient cells. Supplementary Table 1: Phospho-c-Jun Staining in RCC Specimens
Supplementary Table 1 from Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis
Authors: Martini Miriam , Russo Mariangela , Lamba Simona , Vitiello Elisa , Crowley Emily Hannah , Sassi Francesco , Romanelli Davide , Frattini Milo , Marchetti Antonio , Bardelli Alberto
Published: March 2023

PDF file - 47K, List of tumors and number of samples for each histological type used for the mutational profile of MLK4 (GIST: Gastrointestinal Stromal tumors)
Supplementary Figure 1 from Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis
Authors: Martini Miriam , Russo Mariangela , Lamba Simona , Vitiello Elisa , Crowley Emily Hannah , Sassi Francesco , Romanelli Davide , Frattini Milo , Marchetti Antonio , Bardelli Alberto
Published: March 2023

PDF file - 211K, A) Tumors formed by A549 cancer cells expressing wild type or two MLK4 mutants in xenograft mouse models. Cells were injected in the side of nude mice and tumor growth was measured at the indicated time points. Error bars represent s.e.m. B) Upon sacrifice the lungs were labeled by airway perfusion with the India ink, and superficial metastases were counted as described in panel C.*p value < 0.05; **p value < 0.01; error bars represent s.e.m.
Supplementary Methods from Myeloid-Specific Expression of Ron Receptor Kinase Promotes Prostate Tumor Growth
Authors: Gurusamy Devikala , Gray Jerilyn K. , Pathrose Peterson , Kulkarni Rishikesh M. , Finkleman Fred D. , Waltz Susan E.
Published: March 2023

PDF file - 79K
Supplementary Legends from MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells
Authors: Wang Wen-Jun , Wu Si-Pei , Liu Jia-Bin , Shi Yong-Sheng , Huang Xue , Zhang Qian-Bing , Yao Kai-Tai
Published: March 2023

PDF file - 68K, Supplemental Figure Legends
Supplementary Figure 2 from RNA Trafficking by Acute Myelogenous Leukemia Exosomes
Authors: Huan Jianya , Hornick Noah I. , Shurtleff Matthew J. , Skinner Amy M. , Goloviznina Natalya A. , Roberts Charles T. , Kurre Peter
Published: March 2023

PDF file - 456K, Co-culture of AML cells with stromal cell can alter gene expression and protein secretion
Supplementary Figure 2 from Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties
Authors: Augsten Martin , Sjöberg Elin , Frings Oliver , Vorrink Sabine U. , Frijhoff Jeroen , Olsson Eleonor , Borg Åke , Östman Arne
Published: March 2023

PDF file - 46KB, Nos1 knockdown in CXCL14-fibroblasts.
Supplementary Figure 3 from CHD1 Is a 5q21 Tumor Suppressor Required for ERG Rearrangement in Prostate Cancer
Authors: Burkhardt Lia , Fuchs Sarah , Krohn Antje , Masser Sawinee , Mader Malte , Kluth Martina , Bachmann Frederik , Huland Hartwig , Steuber Thomas , Graefen Markus , Schlomm Thorsten , Minner Sarah , Sauter Guido , Sirma Hüseyin , Simon Ronald
Published: March 2023

PDF file - 92K, Impact of sh-RNA mediated knockdown of CHD1 (a), RB1 (b), PTEN (c) and mTOR (d) knockdown on mRNA and protein levels in BPH-1 cells by Taqman.
Supplementary Figure 5 from A Preclinical Assay for Chemosensitivity in Multiple Myeloma
Authors: Khin Zayar P. , Ribeiro Maria L.C. , Jacobson Timothy , Hazlehurst Lori , Perez Lia , Baz Rachid , Shain Kenneth , Silva Ariosto S.
Published: March 2023

PDF file - 677K, In vitro melphalan chemosensitivity of three MM patients.
Supplementary Figures 1 - 7, Table 1 from HMMR Maintains the Stemness and Tumorigenicity of Glioblastoma Stem-like Cells
Authors: Tilghman Jessica , Wu Hao , Sang Yingying , Shi Xiaohai , Guerrero-Cazares Hugo , Quinones-Hinojosa Alfredo , Eberhart Charles G. , Laterra John , Ying Mingyao
Published: March 2023

PDF file - 1756KB, Supplemental Figure 1: Representative results show tumor specimens in GBM tissue array stained with rabbit IgG as the primary antibody. Supplemental Figure 2. HMMR expression in human gliomas. Supplemental Figure 3. HMMR knockdown inhibits cell proliferation. Supplemental Figure 4. HMMR immunohistochemistry (IHC) staining on tumors derived from GBM1A cells infected with HMMR shRNA1 or non-targeting (NT) control shRNA. Supplemental Figure 5. Limiting dilution tumor initiation assay. Supplemental Figure 6. Red and green GBM neurospheres for in vivo dual-color competition assay. Supplemental Figure 7. The correlation between HMMR and OLIG2 expression in human GBM specimens. Supplemental Table 1. HMMR shRNA sequences and qRT-PCR primer sequences.
Supplementary Table S3 from Amplification of FRS2 and Activation of FGFR/FRS2 Signaling Pathway in High-Grade Liposarcoma
Authors: Zhang Keqiang , Chu Kevin , Wu Xiwei , Gao Hanlin , Wang Jinhui , Yuan Yate-Ching , Loera Sofia , Ho Kimberley , Wang Yafan , Chow Warren , Un Frank , Chu Peiguo , Yen Yun
Published: March 2023

Supplementary Table S3 PDF file 147K, List of primers
Supplementary Table S1 from Amplification of FRS2 and Activation of FGFR/FRS2 Signaling Pathway in High-Grade Liposarcoma
Authors: Zhang Keqiang , Chu Kevin , Wu Xiwei , Gao Hanlin , Wang Jinhui , Yuan Yate-Ching , Loera Sofia , Ho Kimberley , Wang Yafan , Chow Warren , Un Frank , Chu Peiguo , Yen Yun
Published: March 2023

Supplementary Table S1 PDF file 125K, Immunohistochemical staining and FISH results of UHGPS
Supplementary Methods from AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors
Authors: Ríos Marcos , Foretz Marc , Viollet Benoit , Prieto Angel , Fraga Máximo , Costoya Jose A. , Señarís Rosa
Published: March 2023

PDF file - 128K, Supplemental materials and methods: Antibodies and reagents, apoptosis and senescence, western blot and subcellular fractionation and immunohistochemistry.
Supplementary Materials and Methods, Supplementary Figure Legends, and Supplementary Figures 1 through 5 from Mechanisms Promoting Escape from Mitotic Stress–Induced Tumor Cell Death
Authors: Sinnott Rebecca , Winters Leah , Larson Brittany , Mytsa Daniela , Taus Patrick , Cappell Kathryn M. , Whitehurst Angelique W.
Published: March 2023

PDF - 195K, Supplementary figure 1 displays micronucleation of paclitaxel resistant NSCLC cells, fate mapping of micronucleated HCC366 cells, and the scheme and full data set results from the pan-genomic screen. Supplementary figure 2 provides raw data for the plot in Figure 2A, mRNA levels following knockdown, off-target analysis and mitotic defects induced by top scoring siRNAs in additional paclitaxel resistant NSCLC cell lines. Supplementary figure 3 displays mitotic transit time and western blots for target depletion in Figure 2C and D, proliferation rates for HCC366 and HBEC3KT cells and HCC366 dose curve for proTAME. Supplementary figure 4 exhibits the frequency of CASC1 amplification in human tumors, quantitation of data presented in 3B, live cell imaging in cells depleted of CASC1 and tubulin changes in HBEC3KT cells following CASC1 depletion. Supplementary figure 5 displays TRIM69's protein structure, E3 ligase activity, association with pericentrin, impact on mitosis and tubulin polymerization and protein interaction network as well as a quantitation of Figure 5C.
Supplementary Table 3 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity
Authors: Cecil Denise L. , Holt Gregory E. , Park Kyong Hwa , Gad Ekram , Rastetter Lauren , Childs Jennifer , Higgins Doreen , Disis Mary L.
Published: March 2023

PDF file - 50KB, Human protein sequence homologies for IGFBP-2 N-terminus.
Supplementary Figure 2 from Nitroreductase, a Near-Infrared Reporter Platform for In Vivo Time-Domain Optical Imaging of Metastatic Cancer
Authors: McCormack Emmet , Silden Elisabeth , West Richard M. , Pavlin Tina , Micklem David R. , Lorens James B. , Haug Bengt Erik , Cooper Michael E. , Gjertsen Bjørn Tore
Published: March 2023

PDF file - 546K, In vitro characterization of NTR/CytoCy5S.
Supplementary Figures S1-S5 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Authors: Santo Evan E. , Stroeken Peter , Sluis Peter V. , Koster Jan , Versteeg Rogier , Westerhout Ellen M.
Published: March 2023

Supplementary Figures S1-S5 PDF file - 807K, Baseline FACS data to Figure 3b (S1); Total FOXO3a and phosphorylated FOXO3a levels correlate with apoptosis across a cell line panel following MK-2206 treatment (S2); Genes regulated by PI3K/AKT signaling and FOXO3a are highly prognostic in the NB88 (S3); Gene regulatory activity of FOXO3a (S4); Kaplan-Meier survival curves for individual FOXO target genes in the NB88 dataset (S5)
Supplementary Figures 1-7, Table 1 from Androgen Receptor Splice Variants Mediate Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cell Lines
Authors: Li Yingming , Chan Siu Chiu , Brand Lucas J. , Hwang Tae Hyun , Silverstein Kevin A.T. , Dehm Scott M.
Published: March 2023

PDF file - 654K, Supplementary Figure 1: Antiandrogens achieve on-target inhibition of full-length AR in 22Rv1 cells Supplementary Figure 2: CWR-R1 cells harboring a 48kb intragenic deletion in AR intron 1 display androgen-independent growth Supplementary Figure 3: Deletion-enriched CWR-R1 cells are resistant to full-length AR targeting Supplementary Figure 4: AKT1 is not an AR-V target in deletion-enriched CWR-R1 cells Supplementary Figure 5: Western blots from biological replicates for microarray analysis with Illumina Beadchips Supplementary Figure 6: Gene networks identified from androgen/AR and AR-V gene lists using Ingeniuty Systems Pathway Analysis Supplementary Figure 7: Gene set enrichment analysis (GSEA) of full-length androgen/AR-specific gene signatures in LNCaP cells Supplementary Table 1: Androgen/AR and AR-V gene lists
Supplementary Table 3 from A Circadian Clock Transcription Model for the Personalization of Cancer Chronotherapy
Authors: Li Xiao-Mei , Mohammad-Djafari Ali , Dumitru Mircea , Dulong Sandrine , Filipski Elisabeth , Siffroi-Fernandez Sandrine , Mteyrek Ali , Scaglione Francesco , Guettier Catherine , Delaunay Franck , Lévi Francis
Published: March 2023

PDF file - 78K, Plasma pharmacokinetic parameters (Mean plus/minus SEM) of irinotecan bioactive metabolite SN-38 according to timing and chronotoxicity classes.
Supplementary Figure 2 from Activated ERBB2/HER2 Licenses Sensitivity to Apoptosis upon Endoplasmic Reticulum Stress through a PERK-Dependent Pathway
Authors: Martín-Pérez Rosa , Palacios Carmen , Yerbes Rosario , Cano-González Ana , Iglesias-Serret Daniel , Gil Joan , Reginato Mauricio J. , López-Rivas Abelardo
Published: March 2023

PDF file - 54KB, Role of UPR branches in ER stress-induced apoptosis.
Supplementary Figure 1 from Targeting Akt3 Signaling in Triple-Negative Breast Cancer
Authors: Chin Y. Rebecca , Yoshida Taku , Marusyk Andriy , Beck Andrew H. , Polyak Kornelia , Toker Alex
Published: March 2023

PDF file - 164K, AKT3 Expression and Survival in TNBC.
Supplementary Figure Legends from Whole-Genome Sequencing of Asian Lung Cancers: Second-Hand Smoke Unlikely to Be Responsible for Higher Incidence of Lung Cancer among Asian Never-Smokers
Authors: Krishnan Vidhya G. , Ebert Philip J. , Ting Jason C. , Lim Elaine , Wong Swee-Seong , Teo Audrey S.M. , Yue Yong G. , Chua Hui-Hoon , Ma Xiwen , Loh Gary S.L. , Lin Yuhao , Tan Joanna H.J. , Yu Kun , Zhang Shenli , Reinhard Christoph , Tan Daniel S.W. , Peters Brock A. , Lincoln Stephen E. , Ballinger Dennis G. , Laramie Jason M. , Nilsen Geoffrey B. , Barber Thomas D. , Tan Patrick , Hillmer Axel M. , Ng Pauline C.
Published: March 2023

Legend for Supplementary Figures S1-S2.
Supplementary Materials and Methods from Potassium Channel KCNA1 Modulates Oncogene-Induced Senescence and Transformation
Authors: Lallet-Daher Hélène , Wiel Clotilde , Gitenay Delphine , Navaratnam Naveenan , Augert Arnaud , Le Calvé Benjamin , Verbeke Stéphanie , Carling David , Aubert Sébastien , Vindrieux David , Bernard David
Published: March 2023

PDF - 100KB, Supplementary Materials and Methods
Supplementary Figure 8 from Potassium Channel KCNA1 Modulates Oncogene-Induced Senescence and Transformation
Authors: Lallet-Daher Hélène , Wiel Clotilde , Gitenay Delphine , Navaratnam Naveenan , Augert Arnaud , Le Calvé Benjamin , Verbeke Stéphanie , Carling David , Aubert Sébastien , Vindrieux David , Bernard David
Published: March 2023

PDF - 2383KB, PKA activation reverses the transformation blockage induced by KCNA1.
Data Supplement from Osteopontin Shapes Immunosuppression in the Metastatic Niche
Authors: Sangaletti Sabina , Tripodo Claudio , Sandri Sara , Torselli Ilaria , Vitali Caterina , Ratti Chiara , Botti Laura , Burocchi Alessia , Porcasi Rossana , Tomirotti Andrea , Colombo Mario P. , Chiodoni Claudia
Published: March 2023

Supplemental Figure 1. OPN-silencing in tumor cells affects their migratory and invasive capacity in vitro and metastatic potential in vivo.
Supplementary Figure 1 from Glioblastoma Cell Enrichment Is Critical for Analysis of Phosphorylated Drug Targets and Proteomic–Genomic Correlations
Authors: Mueller Claudius , deCarvalho Ana C. , Mikkelsen Tom , Lehman Norman L. , Calvert Valerie , Espina Virginia , Liotta Lance A. , Petricoin Emanuel F.
Published: March 2023

PDF file - 197K, Protein/Phosphoprotein comparison between matched LCM and non-LCM samples by unsupervised hierarchical clustering.
Supplementary Figure 2 from Detection of Brain Tumor Cells in the Peripheral Blood by a Telomerase Promoter-Based Assay
Authors: MacArthur Kelly M. , Kao Gary D. , Chandrasekaran Sanjay , Alonso-Basanta Michelle , Chapman Christina , Lustig Robert A. , Wileyto E. Paul , Hahn Stephen M. , Dorsey Jay F.
Published: March 2023

PDF file - 95KB, Supplementary Figure 2. Representative scattergrams of cell counts from blood obtained from normal healthy volunteers and glioma patients and processed via CTC assay.
Supplementary Table 1 from miR-30-5p Functions as a Tumor Suppressor and Novel Therapeutic Tool by Targeting the Oncogenic Wnt/β-Catenin/BCL9 Pathway
Authors: Zhao Jian-Jun , Lin Jianhong , Zhu Di , Wang Xujun , Brooks Daniel , Chen Ming , Chu Zhang-Bo , Takada Kohichi , Ciccarelli Bryan , Admin Samir , Tao Jianguo , Tai Yu-Tzu , Treon Steven , Pinkus Geraldine , Kuo Winston Patrick , Hideshima Teru , Bouxsein Mary , Munshi Nikhil , Anderson Kenneth , Carrasco Ruben
Published: March 2023

PDF file - 179KB, Sequence of oligonucleotides used in this study.
Data Supplement from High-Throughput Time-Resolved FRET Reveals Akt/PKB Activation as a Poor Prognostic Marker in Breast Cancer
Authors: Veeriah Selvaraju , Leboucher Pierre , de Naurois Julien , Jethwa Nirmal , Nye Emma , Bunting Tamara , Stone Richard , Stamp Gordon , Calleja Véronique , Jeffrey Stefanie S. , Parker Peter J. , Larijani Banafshé
Published: March 2023

Supplementary Figure 2: Localization of endogenous Akt and pAkt (pT308) in SKBR3 cells and FFPE human breast tumor tissues using TSA amplified immunofluorescence.
Data Supplement from High-Throughput Time-Resolved FRET Reveals Akt/PKB Activation as a Poor Prognostic Marker in Breast Cancer
Authors: Veeriah Selvaraju , Leboucher Pierre , de Naurois Julien , Jethwa Nirmal , Nye Emma , Bunting Tamara , Stone Richard , Stamp Gordon , Calleja Véronique , Jeffrey Stefanie S. , Parker Peter J. , Larijani Banafshé
Published: March 2023

Supplementary Figure 5: Molecular heterogeneity of Akt activation in human colon TMA revealed by amplified FRET.
Supplementary Figure 2 from The DREAM Complex Mediates GIST Cell Quiescence and Is a Novel Therapeutic Target to Enhance Imatinib-Induced Apoptosis
Authors: Boichuk Sergei , Parry Joshua A. , Makielski Kathleen R. , Litovchick Larisa , Baron Julianne L. , Zewe James P. , Wozniak Agnieszka , Mehalek Keith R. , Korzeniewski Nina , Seneviratne Danushka S. , Schöffski Patrick , Debiec-Rychter Maria , DeCaprio James A. , Duensing Anette
Published: March 2023

PDF file - 3386K, Supplemental Figure 2. GIST cell growth completely recovers after imatinib washout.
Data Supplement from Genetic Ablation of Metadherin Inhibits Autochthonous Prostate Cancer Progression and Metastasis
Authors: Wan Liling , Hu Guohong , Wei Yong , Yuan Min , Bronson Roderick T. , Yang Qifeng , Siddiqui Javed , Pienta Kenneth J. , Kang Yibin
Published: March 2023

Supplementary Methods, Figures 1-5, Table 1. Supplementary Materials and Methods. Supplemental Figure S1. Whole-organism knockout of Mtdh does not affect prostate gland development. Supplemental Figure S2. Mtdh ablation does not affect the expression of Probasin promoter-driven expression of SV40 antigens. Supplemental Figure S3. Loss of Mtdh inhibits the formation of diverse subtypes of prostate cancer in TRAMP mice. Supplemental Figure S4. Analyses of proliferation and apoptosis indices in prostate tissues from TRAMP/Mtdh+ and TRAMP/Mtdh- mice. Supplemental Figure S5. Silencing of Mtdh in TRAMP-C1 tumor cells impairs tumor formation in vivo. Supplemental Table 1: Clinical sample information for IHC and FISH analysis.
Supplemental Figure 6 from Mitochondrial MKP1 Is a Target for Therapy-Resistant HER2-Positive Breast Cancer Cells
Authors: Candas Demet , Lu Chung-Ling , Fan Ming , Chuang Frank Y.S. , Sweeney Colleen , Borowsky Alexander D. , Li Jian Jian
Published: March 2023

Supplemental Figure 6. Cell viability after HER2 inhibitor, Lapatinib, treatment in MCF7/C6 and SKBR3 cells
Supplementary Table S3 from TGFβ Receptor 1: An Immune Susceptibility Gene in HPV-Associated Cancer
Authors: Levovitz Chaya , Chen Dan , Ivansson Emma , Gyllensten Ulf , Finnigan John P. , Alshawish Sara , Zhang Weijia , Schadt Eric E. , Posner Marshal R. , Genden Eric M. , Boffetta Paolo , Sikora Andrew G.
Published: March 2023

Supplementary Table S3. GGI analysis p-values determined using GRAIL